                               SEQUENCE LISTING

<110> CAMP4 THERAPEUTICS CORPORATION
 
<120> IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS

<130> 2093.1300PCT

<140>
<141>

<150> 62/501,795
<151> 2017-05-05

<160> 71281 

<170> PatentIn version 3.5

<210> 1
<211> 9
<212> DNA
<213> Homo sapiens

<400> 1
aaaagtcaa                                                                9


<210> 2
<211> 16
<212> DNA
<213> Homo sapiens

<400> 2
aaaatggcgc catttt                                                       16


<210> 3
<211> 10
<212> DNA
<213> Homo sapiens

<400> 3
aaaccacaaa                                                              10


<210> 4
<211> 10
<212> DNA
<213> Homo sapiens

<400> 4
aaagtaaaca                                                              10


<210> 5
<211> 14
<212> DNA
<213> Homo sapiens

<400> 5
aaatggcgcc attt                                                         14


<210> 6
<211> 10
<212> DNA
<213> Homo sapiens

<400> 6
aacagctgtt                                                              10


<210> 7
<211> 10
<212> DNA
<213> Homo sapiens

<400> 7
aacatctgga                                                              10


<210> 8
<211> 10
<212> DNA
<213> Homo sapiens

<400> 8
aaccggaagt                                                              10


<210> 9
<211> 12
<212> DNA
<213> Homo sapiens

<400> 9
aatggcgcca aa                                                           12


<210> 10
<211> 13
<212> DNA
<213> Homo sapiens

<400> 10
aattggccaa tta                                                          13


<210> 11
<211> 10
<212> DNA
<213> Homo sapiens

<400> 11
acaggaagtg                                                              10


<210> 12
<211> 10
<212> DNA
<213> Homo sapiens

<400> 12
acatcctggt                                                              10


<210> 13
<211> 12
<212> DNA
<213> Homo sapiens

<400> 13
acccttgaac cc                                                           12


<210> 14
<211> 10
<212> DNA
<213> Homo sapiens

<400> 14
accgaacaat                                                              10


<210> 15
<211> 7
<212> DNA
<213> Homo sapiens

<400> 15
acgcgtc                                                                  7


<210> 16
<211> 12
<212> DNA
<213> Homo sapiens

<400> 16
actacaattc cc                                                           12


<210> 17
<211> 10
<212> DNA
<213> Homo sapiens

<400> 17
actgaaacca                                                              10


<210> 18
<211> 12
<212> DNA
<213> Homo sapiens

<400> 18
actttcactt tc                                                           12


<210> 19
<211> 15
<212> DNA
<213> Homo sapiens

<400> 19
agaaatgact tccct                                                        15


<210> 20
<211> 10
<212> DNA
<213> Homo sapiens

<400> 20
agaggaagtg                                                              10


<210> 21
<211> 7
<212> DNA
<213> Homo sapiens

<400> 21
agataag                                                                  7


<210> 22
<211> 8
<212> DNA
<213> Homo sapiens

<400> 22
aggcctag                                                                 8


<210> 23
<211> 8
<212> DNA
<213> Homo sapiens

<400> 23
aggcctgg                                                                 8


<210> 24
<211> 12
<212> DNA
<213> Homo sapiens

<400> 24
aggtctctaa cc                                                           12


<210> 25
<211> 8
<212> DNA
<213> Homo sapiens

<400> 25
aggtgtga                                                                 8


<210> 26
<211> 20
<212> DNA
<213> Homo sapiens

<400> 26
aggtgtgaaa aaaggtgtga                                                   20


<210> 27
<211> 16
<212> DNA
<213> Homo sapiens

<400> 27
aggtgtgaag gtgtga                                                       16


<210> 28
<211> 8
<212> DNA
<213> Homo sapiens

<400> 28
ataacatg                                                                 8


<210> 29
<211> 20
<212> DNA
<213> Homo sapiens

<400> 29
atagtgccac ctggtggcca                                                   20


<210> 30
<211> 15
<212> DNA
<213> Homo sapiens

<400> 30
atcaataaca ttgat                                                        15


<210> 31
<211> 15
<212> DNA
<213> Homo sapiens

<400> 31
atcaattgca gtgat                                                        15


<210> 32
<211> 10
<212> DNA
<213> Homo sapiens

<400> 32
atcacgtgat                                                              10


<210> 33
<211> 15
<212> DNA
<213> Homo sapiens

<400> 33
atgaataaca ttcat                                                        15


<210> 34
<211> 15
<212> DNA
<213> Homo sapiens

<400> 34
atgaattgca gtcat                                                        15


<210> 35
<211> 10
<212> DNA
<213> Homo sapiens

<400> 35
atgacgtcat                                                              10


<210> 36
<211> 9
<212> DNA
<213> Homo sapiens

<400> 36
atgactcat                                                                9


<210> 37
<211> 10
<212> DNA
<213> Homo sapiens

<400> 37
atgactcatc                                                              10


<210> 38
<211> 12
<212> DNA
<213> Homo sapiens

<400> 38
atgccctgag gc                                                           12


<210> 39
<211> 10
<212> DNA
<213> Homo sapiens

<400> 39
attgcgcaac                                                              10


<210> 40
<211> 12
<212> DNA
<213> Homo sapiens

<400> 40
caagatggcg gc                                                           12


<210> 41
<211> 11
<212> DNA
<213> Homo sapiens

<400> 41
caccgaacaa t                                                            11


<210> 42
<211> 5
<212> DNA
<213> Homo sapiens

<400> 42
ccaat                                                                    5


<210> 43
<211> 12
<212> DNA
<213> Homo sapiens

<400> 43
ccatgccgcc at                                                           12


<210> 44
<211> 8
<212> DNA
<213> Homo sapiens

<400> 44
ccccgcgc                                                                 8


<210> 45
<211> 10
<212> DNA
<213> Homo sapiens

<400> 45
cgcagctgcg                                                              10


<210> 46
<211> 8
<212> DNA
<213> Homo sapiens

<400> 46
cgcgaaaa                                                                 8


<210> 47
<211> 10
<212> DNA
<213> Homo sapiens

<400> 47
cggacacaat                                                              10


<210> 48
<211> 16
<212> DNA
<213> Homo sapiens

<400> 48
cggttgccat ggcaac                                                       16


<210> 49
<211> 10
<212> DNA
<213> Homo sapiens

<400> 49
cggtttcaaa                                                              10


<210> 50
<211> 12
<212> DNA
<213> Homo sapiens

<400> 50
cgtgggtggt cc                                                           12


<210> 51
<211> 8
<212> DNA
<213> Homo sapiens

<400> 51
ctaattag                                                                 8


<210> 52
<211> 12
<212> DNA
<213> Homo sapiens

<400> 52
ctgcgcatgc gc                                                           12


<210> 53
<211> 7
<212> DNA
<213> Homo sapiens

<400> 53
cttcgag                                                                  7


<210> 54
<211> 12
<212> DNA
<213> Homo sapiens

<400> 54
gaaagtgaaa gt                                                           12


<210> 55
<211> 14
<212> DNA
<213> Homo sapiens

<400> 55
gaggtcaaag gtca                                                         14


<210> 56
<211> 12
<212> DNA
<213> Homo sapiens

<400> 56
gatgacgtca tc                                                           12


<210> 57
<211> 12
<212> DNA
<213> Homo sapiens

<400> 57
gatgactcag ca                                                           12


<210> 58
<211> 10
<212> DNA
<213> Homo sapiens

<400> 58
gattgcatca                                                              10


<210> 59
<211> 8
<212> DNA
<213> Homo sapiens

<400> 59
gcacttaa                                                                 8


<210> 60
<211> 16
<212> DNA
<213> Homo sapiens

<400> 60
gcagccaagc gtgacc                                                       16


<210> 61
<211> 8
<212> DNA
<213> Homo sapiens

<400> 61
gctaatcc                                                                 8


<210> 62
<211> 12
<212> DNA
<213> Homo sapiens

<400> 62
gcttttccca ca                                                           12


<210> 63
<211> 7
<212> DNA
<213> Homo sapiens

<400> 63
ggaccct                                                                  7


<210> 64
<211> 12
<212> DNA
<213> Homo sapiens

<400> 64
ggccataaat ca                                                           12


<210> 65
<211> 12
<212> DNA
<213> Homo sapiens

<400> 65
gggggtgtgt cc                                                           12


<210> 66
<211> 14
<212> DNA
<213> Homo sapiens

<400> 66
ggggtcaaag gtca                                                         14


<210> 67
<211> 10
<212> DNA
<213> Homo sapiens

<400> 67
ggtcacgtga                                                              10


<210> 68
<211> 12
<212> DNA
<213> Homo sapiens

<400> 68
ggtccctagg ga                                                           12


<210> 69
<211> 7
<212> DNA
<213> Homo sapiens

<400> 69
gtaaaca                                                                  7


<210> 70
<211> 8
<212> DNA
<213> Homo sapiens

<400> 70
gtaaacaa                                                                 8


<210> 71
<211> 14
<212> DNA
<213> Homo sapiens

<400> 71
gtaaacatgt ttac                                                         14


<210> 72
<211> 9
<212> DNA
<213> Homo sapiens

<400> 72
gtaataaaa                                                                9


<210> 73
<211> 10
<212> DNA
<213> Homo sapiens

<400> 73
gtacctacct                                                              10


<210> 74
<211> 8
<212> DNA
<213> Homo sapiens

<400> 74
gtcacgtg                                                                 8


<210> 75
<211> 10
<212> DNA
<213> Homo sapiens

<400> 75
gtcacgtgac                                                              10


<210> 76
<211> 12
<212> DNA
<213> Homo sapiens

<400> 76
gtccccaggg ga                                                           12


<210> 77
<211> 12
<212> DNA
<213> Homo sapiens

<400> 77
gtgcgcatgc gc                                                           12


<210> 78
<211> 10
<212> DNA
<213> Homo sapiens

<400> 78
gtgggcccca                                                              10


<210> 79
<211> 16
<212> DNA
<213> Homo sapiens

<400> 79
tcacacctag gtgtga                                                       16


<210> 80
<211> 7
<212> DNA
<213> Homo sapiens

<400> 80
tcacgtg                                                                  7


<210> 81
<211> 16
<212> DNA
<213> Homo sapiens

<400> 81
tgacctttaa aggtca                                                       16


<210> 82
<211> 14
<212> DNA
<213> Homo sapiens

<400> 82
tgatgacgtc atca                                                         14


<210> 83
<211> 12
<212> DNA
<213> Homo sapiens

<400> 83
tgccacgtgg ca                                                           12


<210> 84
<211> 7
<212> DNA
<213> Homo sapiens

<400> 84
tgctggt                                                                  7


<210> 85
<211> 10
<212> DNA
<213> Homo sapiens

<400> 85
tggcagttgg                                                              10


<210> 86
<211> 8
<212> DNA
<213> Homo sapiens

<400> 86
ttacgtaa                                                                 8


<210> 87
<211> 7
<212> DNA
<213> Homo sapiens

<400> 87
ttactaa                                                                  7


<210> 88
<211> 13
<212> DNA
<213> Homo sapiens

<400> 88
ttgccatggc aac                                                          13


<210> 89
<211> 8
<212> DNA
<213> Homo sapiens

<400> 89
ttgtttac                                                                 8


<210> 90
<211> 11
<212> DNA
<213> Homo sapiens

<400> 90
tttaaaggtc a                                                            11


<210> 91
<211> 11
<212> DNA
<213> Homo sapiens

<400> 91
tttccccaca c                                                            11


<210> 92
<211> 12
<212> DNA
<213> Homo sapiens

<400> 92
tttccccaca cg                                                           12


<210> 93
<211> 12
<212> DNA
<213> Homo sapiens

<400> 93
tttcccgcca aa                                                           12


<210> 94
<211> 12
<212> DNA
<213> Homo sapiens

<400> 94
tttggcgcca aa                                                           12


<210> 95
<211> 14
<212> DNA
<213> Homo sapiens

<400> 95
ttttccatgg aaaa                                                         14


<210> 96
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 96
aaaaagcgga agtn                                                         14


<210> 97
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (17)..(18)
<223> a, c, t, g, unknown or other

<400> 97
aaaaatggcg ccaaaann                                                     18


<210> 98
<211> 15
<212> DNA
<213> Homo sapiens

<400> 98
aaagatcaaa ggrww                                                        15


<210> 99
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 99
aacccggaag tn                                                           12


<210> 100
<211> 12
<212> DNA
<213> Homo sapiens

<400> 100
aacccggaag tr                                                           12


<210> 101
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(14)
<223> a, c, t, g, unknown or other

<400> 101
aaccgttaac ggnn                                                         14


<210> 102
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 102
acccggaagt n                                                            11


<210> 103
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 103
accggaagtn                                                              10


<210> 104
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 104
accggaaryn                                                              10


<210> 105
<211> 7
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<400> 105
agataan                                                                  7


<210> 106
<211> 8
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<400> 106
agataann                                                                 8


<210> 107
<211> 8
<212> DNA
<213> Homo sapiens

<400> 107
agataasr                                                                 8


<210> 108
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 108
aggtgtgann                                                              10


<210> 109
<211> 8
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<400> 109
aggtgtnr                                                                 8


<210> 110
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 110
ccaataaaan                                                              10


<210> 111
<211> 14
<212> DNA
<213> Homo sapiens

<400> 111
ccgaaaccga aacy                                                         14


<210> 112
<211> 7
<212> DNA
<213> Homo sapiens

<400> 112
ctcgagg                                                                  7


<210> 113
<211> 7
<212> DNA
<213> Homo sapiens

<400> 113
gcttccw                                                                  7


<210> 114
<211> 10
<212> DNA
<213> Homo sapiens

<400> 114
ggcgggaaah                                                              10


<210> 115
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 115
ggcgggaarn                                                              10


<210> 116
<211> 8
<212> DNA
<213> Homo sapiens

<400> 116
ghcacgtg                                                                 8


<210> 117
<211> 8
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<400> 117
gncacgtg                                                                 8


<210> 118
<211> 8
<212> DNA
<213> Homo sapiens

<400> 118
gtaaacaw                                                                 8


<210> 119
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 119
tcaaggtcaw n                                                            11


<210> 120
<211> 7
<212> DNA
<213> Homo sapiens

<400> 120
tgcaccy                                                                  7


<210> 121
<211> 7
<212> DNA
<213> Homo sapiens

<400> 121
tgcattt                                                                  7


<210> 122
<211> 6
<212> DNA
<213> Homo sapiens

<400> 122
tgctgg                                                                   6


<210> 123
<211> 17
<212> DNA
<213> Homo sapiens

<400> 123
tgctttctag gaattmm                                                      17


<210> 124
<211> 12
<212> DNA
<213> Homo sapiens

<400> 124
tggggaaggg cm                                                           12


<210> 125
<211> 8
<212> DNA
<213> Homo sapiens

<400> 125
ttgacags                                                                 8


<210> 126
<211> 14
<212> DNA
<213> Homo sapiens

<400> 126
ttttcccgcc aaaw                                                         14


<210> 127
<211> 11
<212> DNA
<213> Homo sapiens

<400> 127
aaagtaaaca a                                                            11


<210> 128
<211> 15
<212> DNA
<213> Homo sapiens

<400> 128
aacaatamca ttgtt                                                        15


<210> 129
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 129
aacaatanca ttgtt                                                        15


<210> 130
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 130
aacaatknya gtgtt                                                        15


<210> 131
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<400> 131
aacaatnnca ttgtt                                                        15


<210> 132
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, t, g, unknown or other

<400> 132
aacaatnnna gtgtt                                                        15


<210> 133
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, t, g, unknown or other

<400> 133
aacaatnnnc attgtt                                                       16


<210> 134
<211> 10
<212> DNA
<213> Homo sapiens

<400> 134
aacavbtgtt                                                              10


<210> 135
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<400> 135
aaccggwnnn wccggtt                                                      17


<210> 136
<211> 15
<212> DNA
<213> Homo sapiens

<400> 136
aagaacatwh tgttc                                                        15


<210> 137
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<400> 137
aaggtcannn naaggtca                                                     18


<210> 138
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (3)..(3)
<223> a, c, t, g, unknown or other

<400> 138
aantaggtca gtaggtca                                                     18


<210> 139
<211> 16
<212> DNA
<213> Homo sapiens

<400> 139
aarggtcaaa aggtca                                                       16


<210> 140
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<400> 140
acaatancat tg                                                           12


<210> 141
<211> 14
<212> DNA
<213> Homo sapiens

<400> 141
accggawatc cggt                                                         14


<210> 142
<211> 16
<212> DNA
<213> Homo sapiens

<400> 142
accgttarra ccgtta                                                       16


<210> 143
<211> 14
<212> DNA
<213> Homo sapiens

<400> 143
actactawww wtag                                                         14


<210> 144
<211> 10
<212> DNA
<213> Homo sapiens

<400> 144
acvaggaagt                                                              10


<210> 145
<211> 15
<212> DNA
<213> Homo sapiens

<400> 145
agatgkdgag ataag                                                        15


<210> 146
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(11)
<223> a, c, t, g, unknown or other

<400> 146
aggtcannnn ntgacct                                                      17


<210> 147
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 147
aggtgtgaan ttcacacct                                                    19


<210> 148
<211> 19
<212> DNA
<213> Homo sapiens

<400> 148
aggtgtgaaw ttcacacct                                                    19


<210> 149
<211> 19
<212> DNA
<213> Homo sapiens

<400> 149
aggtgtgaww wtcacacct                                                    19


<210> 150
<211> 18
<212> DNA
<213> Homo sapiens

<400> 150
agtgttaaca garcacct                                                     18


<210> 151
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<400> 151
anacagctgc                                                              10


<210> 152
<211> 8
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<400> 152
ancagctg                                                                 8


<210> 153
<211> 15
<212> DNA
<213> Homo sapiens

<400> 153
arggtcaaaa ggtca                                                        15


<210> 154
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 154
ataaacaanw gtaaaca                                                      17


<210> 155
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<400> 155
atcaatnnca ttgat                                                        15


<210> 156
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 156
atgaatknya gtc                                                          13


<210> 157
<211> 15
<212> DNA
<213> Homo sapiens

<400> 157
atgaatwyca ttcat                                                        15


<210> 158
<211> 9
<212> DNA
<213> Homo sapiens

<400> 158
atgastcat                                                                9


<210> 159
<211> 16
<212> DNA
<213> Homo sapiens

<400> 159
atgcgggyrc ccgcat                                                       16


<210> 160
<211> 14
<212> DNA
<213> Homo sapiens

<400> 160
atgmataatt aatg                                                         14


<210> 161
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<400> 161
atttctnaga aa                                                           12


<210> 162
<211> 10
<212> DNA
<213> Homo sapiens

<400> 162
avcaggaagt                                                              10


<210> 163
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(11)
<223> a, c, t, g, unknown or other

<400> 163
cacgtgnnnn ncacgtg                                                      17


<210> 164
<211> 8
<212> DNA
<213> Homo sapiens

<400> 164
cgataasc                                                                 8


<210> 165
<211> 6
<212> DNA
<213> Homo sapiens

<400> 165
cggccg                                                                   6


<210> 166
<211> 14
<212> DNA
<213> Homo sapiens

<400> 166
cggasrswys ccga                                                         14


<210> 167
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 167
cttggcacng tgccaa                                                       16


<210> 168
<211> 10
<212> DNA
<213> Homo sapiens

<400> 168
cwggcgggaa                                                              10


<210> 169
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (12)..(13)
<223> a, c, t, g, unknown or other

<400> 169
gaccccccgc gnng                                                         14


<210> 170
<211> 10
<212> DNA
<213> Homo sapiens

<400> 170
gagsccgagc                                                              10


<210> 171
<211> 15
<212> DNA
<213> Homo sapiens

<400> 171
gartggtcat cgccc                                                        15


<210> 172
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 172
gcgaccacnc tg                                                           12


<210> 173
<211> 8
<212> DNA
<213> Homo sapiens

<400> 173
gggtgcat                                                                 8


<210> 174
<211> 25
<212> DNA
<213> Homo sapiens

<400> 174
gggttttgaa ggatgartag gagtt                                             25


<210> 175
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (3)..(3)
<223> a, c, t, g, unknown or other

<400> 175
ggntctcgcg agaac                                                        15


<210> 176
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<400> 176
ggtgtgannt cacacc                                                       16


<210> 177
<211> 16
<212> DNA
<213> Homo sapiens

<400> 177
ggtgtgawat cacacc                                                       16


<210> 178
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<400> 178
gnccacgtgg                                                              10


<210> 179
<211> 12
<212> DNA
<213> Homo sapiens

<400> 179
gsctgtcact ca                                                           12


<210> 180
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 180
gtcacgctcn ctga                                                         14


<210> 181
<211> 15
<212> DNA
<213> Homo sapiens

<400> 181
gtggtcccgg atyat                                                        15


<210> 182
<211> 9
<212> DNA
<213> Homo sapiens

<400> 182
gyaataaaa                                                                9


<210> 183
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<400> 183
taattrnnya atta                                                         14


<210> 184
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 184
taattrsnya atta                                                         14


<210> 185
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<400> 185
taatynaatt a                                                            11


<210> 186
<211> 10
<212> DNA
<213> Homo sapiens

<400> 186
taatyratta                                                              10


<210> 187
<211> 11
<212> DNA
<213> Homo sapiens

<400> 187
taatytaatt a                                                            11


<210> 188
<211> 11
<212> DNA
<213> Homo sapiens

<400> 188
taatyyaatt a                                                            11


<210> 189
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<400> 189
taayynaatt a                                                            11


<210> 190
<211> 9
<212> DNA
<213> Homo sapiens

<400> 190
tatgcwaat                                                                9


<210> 191
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<400> 191
tcaatancat tga                                                          13


<210> 192
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(7)
<223> a, c, t, g, unknown or other

<400> 192
tcaatnncat tga                                                          13


<210> 193
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(8)
<223> a, c, t, g, unknown or other

<400> 193
tcaatnnnat tga                                                          13


<210> 194
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(12)
<223> a, c, t, g, unknown or other

<400> 194
tcacacctnn nnaggtgtga                                                   20


<210> 195
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<400> 195
tgaatancat tca                                                          13


<210> 196
<211> 12
<212> DNA
<213> Homo sapiens

<400> 196
tgacagstgt ca                                                           12


<210> 197
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 197
tgcacacnct gaaaa                                                        15


<210> 198
<211> 10
<212> DNA
<213> Homo sapiens

<400> 198
tggaacagma                                                              10


<210> 199
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (3)..(3)
<223> a, c, t, g, unknown or other

<400> 199
trngtaaaca                                                              10


<210> 200
<211> 9
<212> DNA
<213> Homo sapiens

<400> 200
ttagtmagc                                                                9


<210> 201
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<400> 201
ttccknagaa                                                              10


<210> 202
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, t, g, unknown or other

<400> 202
ttcgaannnt tcgaa                                                        15


<210> 203
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 203
ttctagaann ttc                                                          13


<210> 204
<211> 14
<212> DNA
<213> Homo sapiens

<400> 204
ttgacagstg tcaa                                                         14


<210> 205
<211> 13
<212> DNA
<213> Homo sapiens

<400> 205
tttcaaggcy ccc                                                          13


<210> 206
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 206
tttccaynrt ggaaa                                                        15


<210> 207
<211> 14
<212> DNA
<213> Homo sapiens

<400> 207
tttccccaca crac                                                         14


<210> 208
<211> 10
<212> DNA
<213> Homo sapiens

<400> 208
ttttatkrgg                                                              10


<210> 209
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 209
aaaaagmgga agtn                                                         14


<210> 210
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 210
aaaaagngga agtn                                                         14


<210> 211
<211> 11
<212> DNA
<213> Homo sapiens

<400> 211
aaccggaart r                                                            11


<210> 212
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 212
accggaartn                                                              10


<210> 213
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 213
accggawatc cggn                                                         14


<210> 214
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 214
accggawgyn                                                              10


<210> 215
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 215
aggtcantga cctn                                                         14


<210> 216
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 216
amccggatgt n                                                            11


<210> 217
<211> 12
<212> DNA
<213> Homo sapiens

<400> 217
avytatcgat ad                                                           12


<210> 218
<211> 15
<212> DNA
<213> Homo sapiens

<400> 218
awcgaaaccg aaacy                                                        15


<210> 219
<211> 6
<212> DNA
<213> Homo sapiens

<400> 219
ccaata                                                                   6


<210> 220
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 220
cccatwaaan                                                              10


<210> 221
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 221
ccggaascgg aagtn                                                        15


<210> 222
<211> 10
<212> DNA
<213> Homo sapiens

<400> 222
ccwggaatgy                                                              10


<210> 223
<211> 7
<212> DNA
<213> Homo sapiens

<400> 223
cgsgtaa                                                                  7


<210> 224
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 224
ctcgracccg tgcn                                                         14


<210> 225
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (16)..(17)
<223> a, c, t, g, unknown or other

<400> 225
ctttcccmya acacknn                                                      17


<210> 226
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 226
cyaataaaan                                                              10


<210> 227
<211> 12
<212> DNA
<213> Homo sapiens

<400> 227
gaaasygaaa sy                                                           12


<210> 228
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 228
gaatgacacr gcgn                                                         14


<210> 229
<211> 20
<212> DNA
<213> Homo sapiens

<400> 229
gagcctggta ctgwgcctgr                                                   20


<210> 230
<211> 8
<212> DNA
<213> Homo sapiens

<400> 230
ggcvgttr                                                                 8


<210> 231
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 231
gncacgtgyn                                                              10


<210> 232
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 232
gtaatwaaan                                                              10


<210> 233
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 233
gtcacgcnnm attan                                                        15


<210> 234
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 234
gtcgtwaaan                                                              10


<210> 235
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<400> 235
gttaatnatt aay                                                          13


<210> 236
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 236
taatcratan                                                              10


<210> 237
<211> 10
<212> DNA
<213> Homo sapiens

<400> 237
trtttacttw                                                              10


<210> 238
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 238
tsaaggtcan                                                              10


<210> 239
<211> 8
<212> DNA
<213> Homo sapiens

<400> 239
ttacgyam                                                                 8


<210> 240
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, t, g, unknown or other

<400> 240
ttggcannnt gccar                                                        15


<210> 241
<211> 7
<212> DNA
<213> Homo sapiens

<400> 241
aytraat                                                                  7


<210> 242
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, t, g, unknown or other

<400> 242
aacaatnnna ktgtt                                                        15


<210> 243
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(10)
<223> a, c, t, g, unknown or other

<400> 243
aacaatnnnn aktgtt                                                       16


<210> 244
<211> 15
<212> DNA
<213> Homo sapiens

<400> 244
aaggkgrcgc aggca                                                        15


<210> 245
<211> 14
<212> DNA
<213> Homo sapiens

<400> 245
accctmaagg tyrt                                                         14


<210> 246
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (3)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 246
acngttaaac ng                                                           12


<210> 247
<211> 10
<212> DNA
<213> Homo sapiens

<400> 247
akgmcacgta                                                              10


<210> 248
<211> 10
<212> DNA
<213> Homo sapiens

<400> 248
amcatatgkt                                                              10


<210> 249
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 249
ancatatgnt                                                              10


<210> 250
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<400> 250
anrtaaayaa aca                                                          13


<210> 251
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(11)
<223> a, c, t, g, unknown or other

<400> 251
arrggtcann nrrggtca                                                     18


<210> 252
<211> 10
<212> DNA
<213> Homo sapiens

<400> 252
awcagctgwt                                                              10


<210> 253
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (3)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 253
awntaggtca tgacctanwt                                                   20


<210> 254
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<400> 254
cccgcntnnn rcgaa                                                        15


<210> 255
<211> 9
<212> DNA
<213> Homo sapiens

<400> 255
ccrrtcrgg                                                                9


<210> 256
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (5)..(5)
<223> a, c, t, g, unknown or other

<400> 256
cgtrnaaart ga                                                           12


<210> 257
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(3)
<223> a, c, t, g, unknown or other

<400> 257
cnnbrgcgcc ccctgstggc                                                   20


<210> 258
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (11)..(13)
<223> a, c, t, g, unknown or other

<400> 258
gaccacmcac nnng                                                         14


<210> 259
<211> 11
<212> DNA
<213> Homo sapiens

<400> 259
gccmcgcccm c                                                            11


<210> 260
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 260
gncacgtgnc                                                              10


<210> 261
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 261
grggtcaaaa ggtcana                                                      17


<210> 262
<211> 16
<212> DNA
<213> Homo sapiens

<400> 262
grggtcaaaa gktcac                                                       16


<210> 263
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<400> 263
grgttcannr rgttca                                                       16


<210> 264
<211> 15
<212> DNA
<213> Homo sapiens

<400> 264
gtcwgctgty yctct                                                        15


<210> 265
<211> 13
<212> DNA
<213> Homo sapiens

<400> 265
gttgycatgg aac                                                          13


<210> 266
<211> 12
<212> DNA
<213> Homo sapiens

<400> 266
gycatcmatc at                                                           12


<210> 267
<211> 16
<212> DNA
<213> Homo sapiens

<400> 267
taattagyry tratta                                                       16


<210> 268
<211> 13
<212> DNA
<213> Homo sapiens

<400> 268
taattrcyaa tta                                                          13


<210> 269
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(8)
<223> a, c, t, g, unknown or other

<400> 269
tgaatnnnak tca                                                          13


<210> 270
<211> 14
<212> DNA
<213> Homo sapiens

<400> 270
tgaatrtkca gtca                                                         14


<210> 271
<211> 14
<212> DNA
<213> Homo sapiens

<400> 271
tggkctarcc tcga                                                         14


<210> 272
<211> 8
<212> DNA
<213> Homo sapiens

<400> 272
ttcyattc                                                                 8


<210> 273
<211> 10
<212> DNA
<213> Homo sapiens

<400> 273
tttccratgg                                                              10


<210> 274
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(13)
<223> a, c, t, g, unknown or other

<400> 274
tttcgcntgg cnngtca                                                      17


<210> 275
<211> 16
<212> DNA
<213> Homo sapiens

<400> 275
twcccayaat gcattg                                                       16


<210> 276
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 276
agatstndnn dsagataasn                                                   20


<210> 277
<211> 15
<212> DNA
<213> Homo sapiens

<400> 277
argaggmcaa aatgw                                                        15


<210> 278
<211> 15
<212> DNA
<213> Homo sapiens

<400> 278
atttcccagv akscy                                                        15


<210> 279
<211> 10
<212> DNA
<213> Homo sapiens

<400> 279
ggmratacgs                                                              10


<210> 280
<211> 16
<212> DNA
<213> Homo sapiens

<400> 280
aacaatrtkc agwgtt                                                       16


<210> 281
<211> 15
<212> DNA
<213> Homo sapiens

<400> 281
adggyagyag catct                                                        15


<210> 282
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 282
aggtgtkang gtgtsa                                                       16


<210> 283
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 283
aggtgtkann tmacacct                                                     18


<210> 284
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 284
aggtgtnanw wntnacacct                                                   20


<210> 285
<211> 16
<212> DNA
<213> Homo sapiens

<400> 285
atcaatrtkc agwgat                                                       16


<210> 286
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(11)
<223> a, c, t, g, unknown or other

<400> 286
atcratnnnn natcrat                                                      17


<210> 287
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(12)
<223> a, c, t, g, unknown or other

<400> 287
atcratnnnn nnatcrat                                                     18


<210> 288
<211> 16
<212> DNA
<213> Homo sapiens

<400> 288
atgaatrtkc agwcat                                                       16


<210> 289
<211> 25
<212> DNA
<213> Homo sapiens

<400> 289
cctcatggtg ycytwytccc ttgtg                                             25


<210> 290
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 290
gaccmccyrm tgng                                                         14


<210> 291
<211> 8
<212> DNA
<213> Homo sapiens

<400> 291
gcsgsgsg                                                                 8


<210> 292
<211> 9
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (5)..(5)
<223> a, c, t, g, unknown or other

<400> 292
ggmtnakcc                                                                9


<210> 293
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 293
ggtgtnanww ntnacacc                                                     18


<210> 294
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<400> 294
ggygtgannn ntcacrcc                                                     18


<210> 295
<211> 12
<212> DNA
<213> Homo sapiens

<400> 295
grtgmtrgag cc                                                           12


<210> 296
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(10)
<223> a, c, t, g, unknown or other

<400> 296
taawygnnnn taawyg                                                       16


<210> 297
<211> 14
<212> DNA
<213> Homo sapiens

<400> 297
tgaatrtkca gwca                                                         14


<210> 298
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 298
tgmatwwwtn a                                                            11


<210> 299
<211> 10
<212> DNA
<213> Homo sapiens

<400> 299
tgyayggrtg                                                              10


<210> 300
<211> 13
<212> DNA
<213> Homo sapiens

<400> 300
tktccwttgg aaa                                                          13


<210> 301
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 301
tnacacctnn naggtgtna                                                    19


<210> 302
<211> 15
<212> DNA
<213> Homo sapiens

<400> 302
trggtyasta ggtca                                                        15


<210> 303
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (11)..(13)
<223> a, c, t, g, unknown or other

<400> 303
tytcacacct nnnaggtgtg ara                                               23


<210> 304
<211> 20
<212> DNA
<213> Homo sapiens

<400> 304
aaacykgttw dacmrgtttb                                                   20


<210> 305
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 305
gacccccygy tgngn                                                        15


<210> 306
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<400> 306
tttyacgcwt gantgmnyn                                                    19


<210> 307
<211> 14
<212> DNA
<213> Homo sapiens

<400> 307
accytmargg trtg                                                         14


<210> 308
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 308
cnattaaawa ncnatta                                                      17


<210> 309
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 309
tagayraytg mcangaa                                                      17


<210> 310
<211> 15
<212> DNA
<213> Homo sapiens

<400> 310
twghwacawt gtwdc                                                        15


<210> 311
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 311
gnctgtastr ntgbctchtt                                                   20


<210> 312
<211> 8
<212> DNA
<213> Homo sapiens

<400> 312
gtaaacaa                                                                 8


<210> 313
<211> 10
<212> DNA
<213> Homo sapiens

<400> 313
kccacgtgac                                                              10


<210> 314
<211> 11
<212> DNA
<213> Homo sapiens

<400> 314
mcgcccacgc a                                                            11


<210> 315
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 315
nacccggaag ta                                                           12


<210> 316
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 316
naggtgtgaa                                                              10


<210> 317
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 317
natgcgggta                                                              10


<210> 318
<211> 8
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 318
nccacgtg                                                                 8


<210> 319
<211> 9
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 319
nccacttaa                                                                9


<210> 320
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 320
ncccccccac                                                              10


<210> 321
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 321
ncgaaaccga aact                                                         14


<210> 322
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<400> 322
nncacgtgcc                                                              10


<210> 323
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<400> 323
nngcggaagt g                                                            11


<210> 324
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 324
ntgggtgtgg cc                                                           12


<210> 325
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 325
ntttccagga aa                                                           12


<210> 326
<211> 7
<212> DNA
<213> Homo sapiens

<400> 326
racgcgt                                                                  7


<210> 327
<211> 7
<212> DNA
<213> Homo sapiens

<400> 327
rcacaat                                                                  7


<210> 328
<211> 10
<212> DNA
<213> Homo sapiens

<400> 328
rccggaagtg                                                              10


<210> 329
<211> 15
<212> DNA
<213> Homo sapiens

<400> 329
rrggtcaaaa ggtca                                                        15


<210> 330
<211> 14
<212> DNA
<213> Homo sapiens

<400> 330
rrggtcaaag gtca                                                         14


<210> 331
<211> 15
<212> DNA
<213> Homo sapiens

<400> 331
rrgtccaaag gtcaa                                                        15


<210> 332
<211> 7
<212> DNA
<213> Homo sapiens

<400> 332
rtaaaca                                                                  7


<210> 333
<211> 8
<212> DNA
<213> Homo sapiens

<400> 333
rtaaacaa                                                                 8


<210> 334
<211> 13
<212> DNA
<213> Homo sapiens

<400> 334
rtaaacataa aca                                                          13


<210> 335
<211> 10
<212> DNA
<213> Homo sapiens

<400> 335
rtcatgtgac                                                              10


<210> 336
<211> 12
<212> DNA
<213> Homo sapiens

<400> 336
vdtttcccgc ca                                                           12


<210> 337
<211> 12
<212> DNA
<213> Homo sapiens

<400> 337
wacccggaag ta                                                           12


<210> 338
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (3)..(3)
<223> a, c, t, g, unknown or other

<400> 338
wdnctgggca                                                              10


<210> 339
<211> 10
<212> DNA
<213> Homo sapiens

<400> 339
wwwwsygggg                                                              10


<210> 340
<211> 10
<212> DNA
<213> Homo sapiens

<400> 340
ygtctagaca                                                              10


<210> 341
<211> 6
<212> DNA
<213> Homo sapiens

<400> 341
ytgact                                                                   6


<210> 342
<211> 9
<212> DNA
<213> Homo sapiens

<400> 342
gctgactaa                                                                9


<210> 343
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(12)
<223> a, c, t, g, unknown or other

<400> 343
dnnnggtcan nnh                                                          13


<210> 344
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 344
haataaagnn                                                              10


<210> 345
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 345
hnhnaggtgt ganhh                                                        15


<210> 346
<211> 6
<212> DNA
<213> Homo sapiens

<400> 346
kgctgr                                                                   6


<210> 347
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 347
ksyggaagtn                                                              10


<210> 348
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 348
naaaccggtt tn                                                           12


<210> 349
<211> 9
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 349
naacaatrn                                                                9


<210> 350
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 350
naaccgcaan                                                              10


<210> 351
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 351
naaccggttn                                                              10


<210> 352
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 352
nacacgtgtn                                                              10


<210> 353
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 353
nacccggaag tan                                                          13


<210> 354
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 354
naccgaaacy n                                                            11


<210> 355
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(14)
<223> a, c, t, g, unknown or other

<400> 355
nacgcccacg cann                                                         14


<210> 356
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 356
naggtgtgaa awn                                                          13


<210> 357
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 357
naggtgtgaa n                                                            11


<210> 358
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 358
naggtgtgaw n                                                            11


<210> 359
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 359
natatgctaa tkn                                                          13


<210> 360
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 360
natgacgtca yn                                                           12


<210> 361
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 361
natgcggaag tr                                                           12


<210> 362
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 362
natgcgggta n                                                            11


<210> 363
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 363
natgcgggtn                                                              10


<210> 364
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(11)
<223> a, c, t, g, unknown or other

<400> 364
nccgccattn n                                                            11


<210> 365
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 365
nccgttaacg gn                                                           12


<210> 366
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 366
ncgaaaccga aacy                                                         14


<210> 367
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 367
ncgaaaccga aacyn                                                        15


<210> 368
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 368
ncgaccaccg an                                                           12


<210> 369
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 369
nctaattann                                                              10


<210> 370
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 370
nctcgtaaaa n                                                            11


<210> 371
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 371
ngatgacgtc atcr                                                         14


<210> 372
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(12)
<223> a, c, t, g, unknown or other

<400> 372
ngcgaccacc nn                                                           12


<210> 373
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 373
nggcacgtgc cn                                                           12


<210> 374
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 374
ngtcgtaaaa n                                                            11


<210> 375
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 375
nkcacgtgmn                                                              10


<210> 376
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(18)
<223> a, c, t, g, unknown or other

<400> 376
nnaaatggcg ccaaaann                                                     18


<210> 377
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(18)
<223> a, c, t, g, unknown or other

<400> 377
nnaaatggcg ccatttnn                                                     18


<210> 378
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(11)
<223> a, c, t, g, unknown or other

<400> 378
nnaaccgttn n                                                            11


<210> 379
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(15)
<223> a, c, t, g, unknown or other

<400> 379
nnacgcccac gcann                                                        15


<210> 380
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(16)
<223> a, c, t, g, unknown or other

<400> 380
nnacgcccac gcannn                                                       16


<210> 381
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(14)
<223> a, c, t, g, unknown or other

<400> 381
nnatgacgtc atnn                                                         14


<210> 382
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 382
nncacctgcn                                                              10


<210> 383
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 383
nncacctgnn                                                              10


<210> 384
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 384
nncacgtgnn                                                              10


<210> 385
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 385
nncatatgnn                                                              10


<210> 386
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 386
nnccgccatn w                                                            11


<210> 387
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(15)
<223> a, c, t, g, unknown or other

<400> 387
nngcaacagg tggnn                                                        15


<210> 388
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 388
nngcaacagg tgn                                                          13


<210> 389
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(16)
<223> a, c, t, g, unknown or other

<400> 389
nnggaagtgc ttccnn                                                       16


<210> 390
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 390
nnggattann                                                              10


<210> 391
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(15)
<223> a, c, t, g, unknown or other

<400> 391
nnmcgcccac gcann                                                        15


<210> 392
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(16)
<223> a, c, t, g, unknown or other

<400> 392
nnmcgcccac gcannn                                                       16


<210> 393
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(5)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 393
nnnnntgctg an                                                           12


<210> 394
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 394
nnnntgctga n                                                            11


<210> 395
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(14)
<223> a, c, t, g, unknown or other

<400> 395
nnntggcgcc annn                                                         14


<210> 396
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 396
nnrraaagga aaccgaaact n                                                 21


<210> 397
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 397
nntaaacgnn                                                              10


<210> 398
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(15)
<223> a, c, t, g, unknown or other

<400> 398
nntaatccga ttann                                                        15


<210> 399
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 399
nntaatccnn                                                              10


<210> 400
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 400
nntaattann                                                              10


<210> 401
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 401
nntaattgnn                                                              10


<210> 402
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 402
nntaattrnn                                                              10


<210> 403
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 403
nntccagatg tkn                                                          13


<210> 404
<211> 9
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 404
nntgccaan                                                                9


<210> 405
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 405
nntgccaann                                                              10


<210> 406
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(18)
<223> a, c, t, g, unknown or other

<400> 406
nnttttggcg ccaaaann                                                     18


<210> 407
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 407
nnyaattann                                                              10


<210> 408
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 408
nnymattann                                                              10


<210> 409
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(11)
<223> a, c, t, g, unknown or other

<400> 409
nnytaattan n                                                            11


<210> 410
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 410
nnyttccggg aarnr                                                        15


<210> 411
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 411
nraaagtgaa agtgn                                                        15


<210> 412
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 412
nrcacctgnn                                                              10


<210> 413
<211> 9
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 413
nrcaggtgn                                                                9


<210> 414
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 414
nrcattccwn                                                              10


<210> 415
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 415
nrgataatcy n                                                            11


<210> 416
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 416
nrgtccaaag tccany                                                       16


<210> 417
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 417
nrttacgtaa yn                                                           12


<210> 418
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 418
nryttccggh                                                              10


<210> 419
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 419
nstaattann                                                              10


<210> 420
<211> 8
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 420
ntaatccn                                                                 8


<210> 421
<211> 8
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 421
ntaattan                                                                 8


<210> 422
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 422
ntcaaggtca n                                                            11


<210> 423
<211> 8
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 423
ntgacagn                                                                 8


<210> 424
<211> 7
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<400> 424
ntgacan                                                                  7


<210> 425
<211> 9
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 425
nttaatccn                                                                9


<210> 426
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(12)
<223> a, c, t, g, unknown or other

<400> 426
nwaaccacad nn                                                           12


<210> 427
<211> 8
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 427
nyaattan                                                                 8


<210> 428
<211> 9
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 428
nymataaan                                                                9


<210> 429
<211> 8
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 429
nymattan                                                                 8


<210> 430
<211> 8
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (3)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 430
nynattan                                                                 8


<210> 431
<211> 9
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 431
nytaatccn                                                                9


<210> 432
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 432
nytaattarn                                                              10


<210> 433
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 433
nytagttamn                                                              10


<210> 434
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 434
nyytgtttac hn                                                           12


<210> 435
<211> 10
<212> DNA
<213> Homo sapiens

<400> 435
racatatgty                                                              10


<210> 436
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 436
raggtcaaaa ggtcaakn                                                     18


<210> 437
<211> 8
<212> DNA
<213> Homo sapiens

<400> 437
rataaaar                                                                 8


<210> 438
<211> 12
<212> DNA
<213> Homo sapiens

<400> 438
rcggacacaa tr                                                           12


<210> 439
<211> 8
<212> DNA
<213> Homo sapiens

<400> 439
rggattar                                                                 8


<210> 440
<211> 6
<212> DNA
<213> Homo sapiens

<400> 440
rggcam                                                                   6


<210> 441
<211> 12
<212> DNA
<213> Homo sapiens

<400> 441
rgggcactaa cy                                                           12


<210> 442
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (15)..(16)
<223> a, c, t, g, unknown or other

<400> 442
rrggtcaaag tccrnn                                                       16


<210> 443
<211> 8
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 443
rrggtcan                                                                 8


<210> 444
<211> 14
<212> DNA
<213> Homo sapiens

<400> 444
rrggtcatga ccyy                                                         14


<210> 445
<211> 10
<212> DNA
<213> Homo sapiens

<400> 445
rtcacgtgay                                                              10


<210> 446
<211> 9
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, t, g, unknown or other

<400> 446
rtgccmnnn                                                                9


<210> 447
<211> 8
<212> DNA
<213> Homo sapiens

<400> 447
scacgtgs                                                                 8


<210> 448
<211> 8
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 448
symattan                                                                 8


<210> 449
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 449
vcagctgbnn                                                              10


<210> 450
<211> 10
<212> DNA
<213> Homo sapiens

<400> 450
watgcgcatw                                                              10


<210> 451
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 451
wrcgtaacca cgyn                                                         14


<210> 452
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 452
ygcgcatgcg cn                                                           12


<210> 453
<211> 7
<212> DNA
<213> Homo sapiens

<400> 453
ygcggck                                                                  7


<210> 454
<211> 12
<212> DNA
<213> Homo sapiens

<400> 454
yrattgcaat yr                                                           12


<210> 455
<211> 8
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 455
ytaattan                                                                 8


<210> 456
<211> 9
<212> DNA
<213> Homo sapiens

<400> 456
agtaaacaa                                                                9


<210> 457
<211> 6
<212> DNA
<213> Homo sapiens

<400> 457
gcsggg                                                                   6


<210> 458
<211> 10
<212> DNA
<213> Homo sapiens

<400> 458
datgastcat                                                              10


<210> 459
<211> 12
<212> DNA
<213> Homo sapiens

<400> 459
kgmcagcgtg tc                                                           12


<210> 460
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 460
naacaattkc agtgtt                                                       16


<210> 461
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 461
natttccngg aaat                                                         14


<210> 462
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 462
nccgccatnn t                                                            11


<210> 463
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 463
ncyaataaaa                                                              10


<210> 464
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 464
ngyaataaaa                                                              10


<210> 465
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 465
nncatcccat aatantc                                                      17


<210> 466
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 466
nnngcatgtc cngacatgcc                                                   20


<210> 467
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(3)
<223> a, c, t, g, unknown or other

<400> 467
nnngmcacgt catc                                                         14


<210> 468
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(14)
<223> a, c, t, g, unknown or other

<400> 468
nraaggtcaa nnnnrggtca                                                   20


<210> 469
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 469
ntgccacgtc anca                                                         14


<210> 470
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(12)
<223> a, c, t, g, unknown or other

<400> 470
nyaattaaaa nnyaatta                                                     18


<210> 471
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 471
racatgtynn racatgtc                                                     18


<210> 472
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 472
raggtcantc aaggtca                                                      17


<210> 473
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 473
ragtcaanaa gtca                                                         14


<210> 474
<211> 10
<212> DNA
<213> Homo sapiens

<400> 474
rcggcrcggc                                                              10


<210> 475
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, t, g, unknown or other

<400> 475
rgttcrnnnr gttc                                                         14


<210> 476
<211> 8
<212> DNA
<213> Homo sapiens

<400> 476
rmatwcca                                                                 8


<210> 477
<211> 10
<212> DNA
<213> Homo sapiens

<400> 477
rracgcsaaa                                                              10


<210> 478
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<400> 478
rrggtcannn rrggtca                                                      17


<210> 479
<211> 14
<212> DNA
<213> Homo sapiens

<400> 479
rtaaacaata aaya                                                         14


<210> 480
<211> 14
<212> DNA
<213> Homo sapiens

<400> 480
rtaaacarta aaca                                                         14


<210> 481
<211> 13
<212> DNA
<213> Homo sapiens

<400> 481
rtaaacawma aca                                                          13


<210> 482
<211> 7
<212> DNA
<213> Homo sapiens

<400> 482
rtaaaya                                                                  7


<210> 483
<211> 11
<212> DNA
<213> Homo sapiens

<400> 483
rtaaayaaac a                                                            11


<210> 484
<211> 10
<212> DNA
<213> Homo sapiens

<400> 484
rtgtacggrt                                                              10


<210> 485
<211> 19
<212> DNA
<213> Homo sapiens

<400> 485
rtgttaaayg tagattaag                                                    19


<210> 486
<211> 13
<212> DNA
<213> Homo sapiens

<400> 486
wrtaaayaaa caa                                                          13


<210> 487
<211> 9
<212> DNA
<213> Homo sapiens

<400> 487
wttcgaayg                                                                9


<210> 488
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 488
yacgtaacnk acgta                                                        15


<210> 489
<211> 11
<212> DNA
<213> Homo sapiens

<400> 489
yggcgctayc a                                                            11


<210> 490
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, t, g, unknown or other

<400> 490
ytggcannnt gccaa                                                        15


<210> 491
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(9)
<223> a, c, t, g, unknown or other

<400> 491
ytggcnnnnt gccaa                                                        15


<210> 492
<211> 9
<212> DNA
<213> Homo sapiens

<400> 492
acccracmy                                                                9


<210> 493
<211> 11
<212> DNA
<213> Homo sapiens

<400> 493
tgrtagcgcc r                                                            11


<210> 494
<211> 12
<212> DNA
<213> Homo sapiens

<400> 494
kctawaaata gm                                                           12


<210> 495
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 495
mccatatawg gn                                                           12


<210> 496
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 496
naaacgatnn an                                                           12


<210> 497
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 497
naacaatanc attgttn                                                      17


<210> 498
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 498
naacaatkny agtgttn                                                      17


<210> 499
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 499
naacaatnnn attgttn                                                      17


<210> 500
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 500
naaccgcaaa ccrcan                                                       16


<210> 501
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 501
naaccrcaan                                                              10


<210> 502
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 502
naagacgyct tn                                                           12


<210> 503
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<400> 503
naancgaaas yr                                                           12


<210> 504
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 504
naasatcaaa gn                                                           12


<210> 505
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 505
nacayatgnn                                                              10


<210> 506
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 506
nacttccgsc ggaarmn                                                      17


<210> 507
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 507
naggtcamsr tgacctn                                                      17


<210> 508
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 508
namccggaag tr                                                           12


<210> 509
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 509
natcaatanc attgatn                                                      17


<210> 510
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 510
natcaatkny agtgatn                                                      17


<210> 511
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 511
natcaatnnn attgatn                                                      17


<210> 512
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 512
natgaatkny agtcatn                                                      17


<210> 513
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 513
natgastcat n                                                            11


<210> 514
<211> 9
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 514
ncacttnan                                                                9


<210> 515
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 515
nccacttran                                                              10


<210> 516
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 516
nccggawatc cggn                                                         14


<210> 517
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 517
nccggawryr ywtccggn                                                     18


<210> 518
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (6)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 518
nccggnnnnn nccggn                                                       16


<210> 519
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<400> 519
ncgaaanyga aacy                                                         14


<210> 520
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 520
ncgaccaccn an                                                           12


<210> 521
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 521
nctawaaata gm                                                           12


<210> 522
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 522
ngacccccca cgangn                                                       16


<210> 523
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(20)
<223> a, c, t, g, unknown or other

<400> 523
ngaggtcann gagttcannn                                                   20


<210> 524
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (5)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 524
ngccnnnngg cn                                                           12


<210> 525
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (5)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 525
ngccnnnnng gcn                                                          13


<210> 526
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 526
nggggawtcc ccn                                                          13


<210> 527
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 527
ngtcgtwaaa n                                                            11


<210> 528
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(12)
<223> a, c, t, g, unknown or other

<400> 528
ngtcgtwaaa nn                                                           12


<210> 529
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 529
nhaacbgyyv                                                              10


<210> 530
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(14)
<223> a, c, t, g, unknown or other

<400> 530
nmcgcccmcg cann                                                         14


<210> 531
<211> 9
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 531
nmcrattar                                                                9


<210> 532
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(14)
<223> a, c, t, g, unknown or other

<400> 532
nnaaaatcra tann                                                         14


<210> 533
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 533
nnaaaatcra tawn                                                         14


<210> 534
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 534
nnatgaygca atn                                                          13


<210> 535
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(11)
<223> a, c, t, g, unknown or other

<400> 535
nncamttaan n                                                            11


<210> 536
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(16)
<223> a, c, t, g, unknown or other

<400> 536
nnmccatata wggknn                                                       16


<210> 537
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(21)
<223> a, c, t, g, unknown or other

<400> 537
nnnntgctga stcagcannn n                                                 21


<210> 538
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 538
nnrtgacgtc aycn                                                         14


<210> 539
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(15)
<223> a, c, t, g, unknown or other

<400> 539
nntaatccgm ttann                                                        15


<210> 540
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(14)
<223> a, c, t, g, unknown or other

<400> 540
nntcccnngg gann                                                         14


<210> 541
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 541
nntnattann                                                              10


<210> 542
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 542
nnyatgmata attaatn                                                      17


<210> 543
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 543
nrggtcanng gtcan                                                        15


<210> 544
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 544
nrmatwccwn                                                              10


<210> 545
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (3)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 545
nrnwaayrtt knyn                                                         14


<210> 546
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 546
nrttaatnat taacn                                                        15


<210> 547
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 547
nrttacrtaa yn                                                           12


<210> 548
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (5)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 548
nsccnnnggs n                                                            11


<210> 549
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (5)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 549
nsccnnnnng gsn                                                          13


<210> 550
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 550
nsctmattan                                                              10


<210> 551
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 551
ntaattannn taattan                                                      17


<210> 552
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 552
ntaatynrat tan                                                          13


<210> 553
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 553
ntaatytaat tan                                                          13


<210> 554
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 554
ntaayynaat tan                                                          13


<210> 555
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 555
ntaayyyaat tan                                                          13


<210> 556
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 556
ntatcgcgay atr                                                          13


<210> 557
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 557
ntatgcwaat n                                                            11


<210> 558
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 558
ntatygatch                                                              10


<210> 559
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 559
ntgaatnnca ttcan                                                        15


<210> 560
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 560
ntgaatnnna ttcan                                                        15


<210> 561
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 561
ntgaatwnca ttcan                                                        15


<210> 562
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<400> 562
ntgacctnnn nnaggtcan                                                    19


<210> 563
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 563
ntgccacgtc aycn                                                         14


<210> 564
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 564
ntgctgantc agcrn                                                        15


<210> 565
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 565
ntgctgastc agcan                                                        15


<210> 566
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 566
ntgmataatt aatgan                                                       16


<210> 567
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 567
ntmatcatca ttan                                                         14


<210> 568
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 568
nttrcgcaay                                                              10


<210> 569
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 569
nwacayraca wn                                                           12


<210> 570
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 570
nwtatgcwaa tn                                                           12


<210> 571
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 571
nwtatgcwaa ttw                                                          13


<210> 572
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 572
nyaattarnn nyaattan                                                     18


<210> 573
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 573
nytmattann                                                              10


<210> 574
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 574
raccgttaaa cngyy                                                        15


<210> 575
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 575
rcattccnnr cattccn                                                      17


<210> 576
<211> 12
<212> DNA
<213> Homo sapiens

<400> 576
rctawaaata gm                                                           12


<210> 577
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 577
rrggtcannn ggtcan                                                       16


<210> 578
<211> 8
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 578
rtmattan                                                                 8


<210> 579
<211> 10
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 579
sctmattann                                                              10


<210> 580
<211> 9
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 580
waaccrcan                                                                9


<210> 581
<211> 9
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 581
wgtaaayan                                                                9


<210> 582
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 582
wtatgcwaat nw                                                           12


<210> 583
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<400> 583
yaattannct aattr                                                        15


<210> 584
<211> 14
<212> DNA
<213> Homo sapiens

<400> 584
ymattaryta atkr                                                         14


<210> 585
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(11)
<223> a, c, t, g, unknown or other

<400> 585
ytcacacctn naggtgtgar                                                   20


<210> 586
<211> 10
<212> DNA
<213> Homo sapiens

<400> 586
dgggygkggc                                                              10


<210> 587
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 587
ngaccacmca cgwng                                                        15


<210> 588
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 588
ngccacgccc mcnt                                                         14


<210> 589
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 589
ntgmataatt aatkag                                                       16


<210> 590
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 590
nwtatgcwaa tkag                                                         14


<210> 591
<211> 12
<212> DNA
<213> Homo sapiens

<400> 591
rgaattctrg aa                                                           12


<210> 592
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, t, g, unknown or other

<400> 592
rggtcannna rrggtca                                                      17


<210> 593
<211> 12
<212> DNA
<213> Homo sapiens

<400> 593
rgkgggcgkg gc                                                           12


<210> 594
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<400> 594
rrggtcannn araggtca                                                     18


<210> 595
<211> 9
<212> DNA
<213> Homo sapiens

<400> 595
rtcaytacg                                                                9


<210> 596
<211> 11
<212> DNA
<213> Homo sapiens

<400> 596
rtgtayggrt g                                                            11


<210> 597
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 597
saaggtcann tsaaggtca                                                    19


<210> 598
<211> 6
<212> DNA
<213> Homo sapiens

<400> 598
scgcgg                                                                   6


<210> 599
<211> 20
<212> DNA
<213> Homo sapiens

<400> 599
smcagtcwga kggaggaggc                                                   20


<210> 600
<211> 12
<212> DNA
<213> Homo sapiens

<400> 600
wtatgcwaat ka                                                           12


<210> 601
<211> 10
<212> DNA
<213> Homo sapiens

<400> 601
rtcaytyacg                                                              10


<210> 602
<211> 25
<212> DNA
<213> Homo sapiens

<400> 602
maccttcyat ggctccctak tgccy                                             25


<210> 603
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 603
naacaatkny aktgttn                                                      17


<210> 604
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (3)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 604
nancatatgn tn                                                           12


<210> 605
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 605
natgaatkny aktcatn                                                      17


<210> 606
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 606
natggaaanw wwwtttycmn                                                   20


<210> 607
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (5)..(5)
<223> a, c, t, g, unknown or other

<400> 607
ncagnaagam gtawmm                                                       16


<210> 608
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 608
ngcgccmyct agyggtn                                                      17


<210> 609
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (3)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 609
ngntctagaa ccngv                                                        15


<210> 610
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(17)
<223> a, c, t, g, unknown or other

<400> 610
ngtcacgcwt srntgnny                                                     18


<210> 611
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (5)..(5)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 611
ngttnccatg gnaacn                                                       16


<210> 612
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 612
ngttrccatg gyaacn                                                       16


<210> 613
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 613
ngyaatwaaa n                                                            11


<210> 614
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 614
nmcmcgcccm cn                                                           12


<210> 615
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (4)..(5)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(18)
<223> a, c, t, g, unknown or other

<400> 615
nngnnacgcc cmytttnn                                                     18


<210> 616
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 616
nrtmaatatt kayn                                                         14


<210> 617
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 617
ntaattrgya attan                                                        15


<210> 618
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 618
ntgacctnat naggtcan                                                     18


<210> 619
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 619
ntgtttacrg taaayan                                                      17


<210> 620
<211> 8
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 620
ntrakccn                                                                 8


<210> 621
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 621
ntrayntaat can                                                          13


<210> 622
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(17)
<223> a, c, t, g, unknown or other

<400> 622
nwrgccmcgc ccmctnn                                                      17


<210> 623
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 623
nwtrmatatk yawn                                                         14


<210> 624
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 624
rcattccnnr catwccn                                                      17


<210> 625
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(14)
<223> a, c, t, g, unknown or other

<400> 625
rtggaaaant mcnn                                                         14


<210> 626
<211> 15
<212> DNA
<213> Homo sapiens

<400> 626
sgttgcyarg caacs                                                        15


<210> 627
<211> 16
<212> DNA
<213> Homo sapiens

<400> 627
sgttrccatr gcaacs                                                       16


<210> 628
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 628
ssytaatcgr waancgatta r                                                 21


<210> 629
<211> 9
<212> DNA
<213> Homo sapiens

<400> 629
wttramkar                                                                9


<210> 630
<211> 12
<212> DNA
<213> Homo sapiens

<400> 630
wawrtaaaya ww                                                           12


<210> 631
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 631
wnwgtmaata ttracwnw                                                     18


<210> 632
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 632
wrwgtmaaya n                                                            11


<210> 633
<211> 11
<212> DNA
<213> Homo sapiens

<400> 633
wrwrtmaaya w                                                            11


<210> 634
<211> 16
<212> DNA
<213> Homo sapiens

<400> 634
wtaatkagct mattaw                                                       16


<210> 635
<211> 11
<212> DNA
<213> Homo sapiens

<400> 635
ymtgtmtyta w                                                            11


<210> 636
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 636
ngtgttcavt saagcgkaaa                                                   20


<210> 637
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 637
nwtgmataaw tna                                                          13


<210> 638
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 638
sgtcacgcwt gantgma                                                      17


<210> 639
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 639
vagracaknc tgtbc                                                        15


<210> 640
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<400> 640
wawntrggty agtaggtca                                                    19


<210> 641
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 641
wtgmataawt na                                                           12


<210> 642
<211> 12
<212> DNA
<213> Homo sapiens

<400> 642
wtrmatatky aw                                                           12


<210> 643
<211> 25
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 643
ytkgatahag tattctwggt nggca                                             25


<210> 644
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 644
nncngttnnn acngttn                                                      17


<210> 645
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 645
nrgnacannn tgtncyn                                                      17


<210> 646
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 646
nrgwacannn tgtwcyn                                                      17


<210> 647
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 647
ntgacctyan ntraggtcan                                                   20


<210> 648
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 648
raancgaaaw tcgntty                                                      17


<210> 649
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<400> 649
rrgwacannn tgtwcyy                                                      17


<210> 650
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 650
waaccrcaaw aaccrcan                                                     18


<210> 651
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(20)
<223> a, c, t, g, unknown or other

<400> 651
nntcrcacnt angtgygann                                                   20


<210> 652
<211> 18
<212> DNA
<213> Homo sapiens

<400> 652
ywttkckkty yckgykky                                                     18


<210> 653
<211> 11
<212> DNA
<213> Homo sapiens

<400> 653
accggaaatg a                                                            11


<210> 654
<211> 10
<212> DNA
<213> Homo sapiens

<400> 654
ccataaatca                                                              10


<210> 655
<211> 12
<212> DNA
<213> Homo sapiens

<400> 655
taaacaggat ta                                                           12


<210> 656
<211> 9
<212> DNA
<213> Homo sapiens

<400> 656
tgtcaatta                                                                9


<210> 657
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (15)..(16)
<223> a, c, t, g, unknown or other

<400> 657
accggaaaca gctgnn                                                       16


<210> 658
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 658
accggaaatg an                                                           12


<210> 659
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 659
aggtgttaat kn                                                           12


<210> 660
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 660
aggtgttgac an                                                           12


<210> 661
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 661
ctcgtaaaat gyn                                                          13


<210> 662
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 662
gaaaaccgaa an                                                           12


<210> 663
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 663
ggaatgcgga agtn                                                         14


<210> 664
<211> 13
<212> DNA
<213> Homo sapiens

<400> 664
ggaatgttaa ttr                                                          13


<210> 665
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 665
gtgcgggcgg aagtn                                                        15


<210> 666
<211> 13
<212> DNA
<213> Homo sapiens

<400> 666
tcacaccgga wry                                                          13


<210> 667
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (11)..(13)
<223> a, c, t, g, unknown or other

<400> 667
tgttgccgga nnn                                                          13


<210> 668
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<400> 668
acaawrsnnn nnymatta                                                     18


<210> 669
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<400> 669
acaawrsnnn nymatta                                                      17


<210> 670
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<400> 670
acaawrsnnn ymatta                                                       16


<210> 671
<211> 17
<212> DNA
<213> Homo sapiens

<400> 671
aggtgtkaag tcgtaaa                                                      17


<210> 672
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(17)
<223> a, c, t, g, unknown or other

<400> 672
cagctgnnnn nnnnnnntgc ggg                                               23


<210> 673
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(15)
<223> a, c, t, g, unknown or other

<400> 673
cagctgnnnn nnnnntgcgg g                                                 21


<210> 674
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(14)
<223> a, c, t, g, unknown or other

<400> 674
cagctgnnnn nnnntgcggg                                                   20


<210> 675
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(13)
<223> a, c, t, g, unknown or other

<400> 675
cagctgnnnn nnntgcggg                                                    19


<210> 676
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(12)
<223> a, c, t, g, unknown or other

<400> 676
ccggaannnn nncacgtg                                                     18


<210> 677
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(11)
<223> a, c, t, g, unknown or other

<400> 677
ggaatgnnnn nytaatta                                                     18


<210> 678
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(15)
<223> a, c, t, g, unknown or other

<400> 678
ggattannnn nnnnntgcgg g                                                 21


<210> 679
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(13)
<223> a, c, t, g, unknown or other

<400> 679
ggattannnn nnntgcggg                                                    19


<210> 680
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(12)
<223> a, c, t, g, unknown or other

<400> 680
ggattannnn nntgcggg                                                     18


<210> 681
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(11)
<223> a, c, t, g, unknown or other

<400> 681
ggtgtgnnnn ncacgtg                                                      17


<210> 682
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(13)
<223> a, c, t, g, unknown or other

<400> 682
taatknnnnn nnnaaggtca                                                   20


<210> 683
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<400> 683
taatkrngga tta                                                          13


<210> 684
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(10)
<223> a, c, t, g, unknown or other

<400> 684
taatkrnnnn gcaac                                                        15


<210> 685
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(10)
<223> a, c, t, g, unknown or other

<400> 685
taatkrnnnn ggatta                                                       16


<210> 686
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(11)
<223> a, c, t, g, unknown or other

<400> 686
taatkrnnnn ngcaac                                                       16


<210> 687
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(12)
<223> a, c, t, g, unknown or other

<400> 687
taatkrnnnn nnaaggtca                                                    19


<210> 688
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 688
taatkrnrng gatta                                                        15


<210> 689
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(12)
<223> a, c, t, g, unknown or other

<400> 689
taattannnn nncacgtg                                                     18


<210> 690
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(10)
<223> a, c, t, g, unknown or other

<400> 690
tgacannnnn tcatta                                                       16


<210> 691
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 691
tgacansnta attg                                                         14


<210> 692
<211> 12
<212> DNA
<213> Homo sapiens

<400> 692
tmacaccgga ag                                                           12


<210> 693
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<400> 693
tntcacaccg gaaat                                                        15


<210> 694
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 694
acccgcancc ggaagn                                                       16


<210> 695
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(18)
<223> a, c, t, g, unknown or other

<400> 695
accggannta cgcnnnnnyr                                                   20


<210> 696
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<400> 696
aggtgntaat kr                                                           12


<210> 697
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<400> 697
aggtgntaat kw                                                           12


<210> 698
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<400> 698
aggtgntaat tr                                                           12


<210> 699
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 699
atttgcatna caatrn                                                       16


<210> 700
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, t, g, unknown or other

<400> 700
cacgtgnnng cgggy                                                        15


<210> 701
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(20)
<223> a, c, t, g, unknown or other

<400> 701
cacgtgnnnn nsrggaarnn                                                   20


<210> 702
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 702
cacgtgnnnr gattan                                                       16


<210> 703
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(12)
<223> a, c, t, g, unknown or other

<400> 703
cagctgnnnn nncccgcay                                                    19


<210> 704
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 704
cyaataaaat gyn                                                          13


<210> 705
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 705
gtmaacagga wrn                                                          13


<210> 706
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 706
gtmaataagg gyrn                                                         14


<210> 707
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 707
taatgnnnnn cggaagtn                                                     18


<210> 708
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(15)
<223> a, c, t, g, unknown or other

<400> 708
taatkrccgg aagnn                                                        15


<210> 709
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 709
taatkrnnnn ggaagtn                                                      17


<210> 710
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 710
taatkrnnnn nggaagtn                                                     18


<210> 711
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 711
taattrnnnn cggaaryn                                                     18


<210> 712
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 712
tgacaknnna acaatgn                                                      17


<210> 713
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(8)
<223> a, c, t, g, unknown or other

<400> 713
tgacannnta atkr                                                         14


<210> 714
<211> 12
<212> DNA
<213> Homo sapiens

<400> 714
tgacastaat kr                                                           12


<210> 715
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 715
tgttgangcg ggn                                                          13


<210> 716
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 716
tgttgncgga wrn                                                          13


<210> 717
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 717
tgttkmcgga wrn                                                          13


<210> 718
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(14)
<223> a, c, t, g, unknown or other

<400> 718
tgttkmcgga wrnn                                                         14


<210> 719
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 719
tnrcaccgga agn                                                          13


<210> 720
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(14)
<223> a, c, t, g, unknown or other

<400> 720
tnrcaccgga agnn                                                         14


<210> 721
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 721
tnrcaccgga wn                                                           12


<210> 722
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (22)..(23)
<223> a, c, t, g, unknown or other

<400> 722
ttacgtnnnn nnnnnccgga ann                                               23


<210> 723
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(12)
<223> a, c, t, g, unknown or other

<400> 723
accggaartn nnyaatta                                                     18


<210> 724
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<400> 724
aggtgngaar ggatta                                                       16


<210> 725
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<400> 725
aggtgtgnnn natcrat                                                      17


<210> 726
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(14)
<223> a, c, t, g, unknown or other

<400> 726
anccggatnn nnnnmatta                                                    19


<210> 727
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(11)
<223> a, c, t, g, unknown or other

<400> 727
argtgnnnnn nataaa                                                       16


<210> 728
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(14)
<223> a, c, t, g, unknown or other

<400> 728
atcratnnnn nnnnsyattg tt                                                22


<210> 729
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, t, g, unknown or other

<400> 729
cacgtgnnnt aatkat                                                       16


<210> 730
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(17)
<223> a, c, t, g, unknown or other

<400> 730
casstgnnnn nnnnnnntgc ggg                                               23


<210> 731
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(16)
<223> a, c, t, g, unknown or other

<400> 731
casstgnnnn nnnnnntgcg gg                                                22


<210> 732
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(14)
<223> a, c, t, g, unknown or other

<400> 732
casstgnnnn nnnntgcggg                                                   20


<210> 733
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(13)
<223> a, c, t, g, unknown or other

<400> 733
casstgnnnn nnntgcggg                                                    19


<210> 734
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 734
cycataaann tgtca                                                        15


<210> 735
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<400> 735
ggaatknnca sstg                                                         14


<210> 736
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, t, g, unknown or other

<400> 736
ggwatgnnnr taaa                                                         14


<210> 737
<211> 24
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(18)
<223> a, c, t, g, unknown or other

<400> 737
gttgcynnnn nnnnnnnnca sstg                                              24


<210> 738
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<400> 738
gwmaacanns ymrtaaa                                                      17


<210> 739
<211> 14
<212> DNA
<213> Homo sapiens

<400> 739
gwmaacaymr taaa                                                         14


<210> 740
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(10)
<223> a, c, t, g, unknown or other

<400> 740
taatccnnnn casstg                                                       16


<210> 741
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 741
taatkaggtg nka                                                          13


<210> 742
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<400> 742
taatkanngg atta                                                         14


<210> 743
<211> 13
<212> DNA
<213> Homo sapiens

<400> 743
taatkrggtg yka                                                          13


<210> 744
<211> 12
<212> DNA
<213> Homo sapiens

<400> 744
tmacaccyaa ta                                                           12


<210> 745
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 745
tttwatnrnm aaca                                                         14


<210> 746
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 746
aggtgntaat kwnnnntn                                                     18


<210> 747
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 747
aggtgtgncs gttr                                                         14


<210> 748
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 748
aggtgtnnng sgggn                                                        15


<210> 749
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(16)
<223> a, c, t, g, unknown or other

<400> 749
aggtgtnrtr cgggnn                                                       16


<210> 750
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<400> 750
angtgtgaat wcy                                                          13


<210> 751
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 751
angtgtsnna taaan                                                        15


<210> 752
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(21)
<223> a, c, t, g, unknown or other

<400> 752
atrcgggynn nnnywttgtn n                                                 21


<210> 753
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<400> 753
casstgnncc cgcay                                                        15


<210> 754
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 754
casstgnncc ggawryn                                                      17


<210> 755
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(17)
<223> a, c, t, g, unknown or other

<400> 755
casstgnrnn ggaagnn                                                      17


<210> 756
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(13)
<223> a, c, t, g, unknown or other

<400> 756
ctcrtaaawn nnnrmcgttr                                                   20


<210> 757
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 757
ggattannar gtgtkn                                                       16


<210> 758
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 758
ggattannnn atcratn                                                      17


<210> 759
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<400> 759
ggwatgnnnn nncacgtgn                                                    19


<210> 760
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 760
ggwatgnnnn nnncacgtgn                                                   20


<210> 761
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(15)
<223> a, c, t, g, unknown or other

<400> 761
ggwatgnrag gtgnnr                                                       16


<210> 762
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (22)..(23)
<223> a, c, t, g, unknown or other

<400> 762
taatknnnng nnnnnncttc cnn                                               23


<210> 763
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 763
taatkrscgg awgn                                                         14


<210> 764
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<400> 764
tgacagnwaa tcratr                                                       16


<210> 765
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 765
tgttkatrcg ggn                                                          13


<210> 766
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 766
tgttkmcgga wrtn                                                         14


<210> 767
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 767
tmacacmgga arn                                                          13


<210> 768
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 768
ttgcgyaann scggaagn                                                     18


<210> 769
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(10)
<223> a, c, t, g, unknown or other

<400> 769
atcratnnnn ycrtaaa                                                      17


<210> 770
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<400> 770
atratyannn ncacgtg                                                      17


<210> 771
<211> 14
<212> DNA
<213> Homo sapiens

<400> 771
ggwatgygtm aaca                                                         14


<210> 772
<211> 14
<212> DNA
<213> Homo sapiens

<400> 772
tmacacyymr twaa                                                         14


<210> 773
<211> 14
<212> DNA
<213> Homo sapiens

<400> 773
tmrcacctcr twaa                                                         14


<210> 774
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 774
argtgnnann nmwtaaan                                                     18


<210> 775
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(16)
<223> a, c, t, g, unknown or other

<400> 775
argtgtkant ttatnn                                                       16


<210> 776
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(13)
<223> a, c, t, g, unknown or other

<400> 776
argtgtkrnn nnnrgwatgy                                                   20


<210> 777
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 777
cycrtaaatw ccn                                                          13


<210> 778
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<400> 778
gtmaacannn nnatcratn                                                    19


<210> 779
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (11)..(15)
<223> a, c, t, g, unknown or other

<400> 779
tgmatatkca nnnnntaatk r                                                 21


<210> 780
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (11)..(14)
<223> a, c, t, g, unknown or other

<400> 780
tgmatatkca nnnntaatkr                                                   20


<210> 781
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (6)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 781
tnsccnnngg snnncacgtg n                                                 21


<210> 782
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (6)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (22)..(22)
<223> a, c, t, g, unknown or other

<400> 782
tnsccnnngg snnnncacgt gn                                                22


<210> 783
<211> 31
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (6)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(24)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (31)..(31)
<223> a, c, t, g, unknown or other

<400> 783
tnsccnnngg snnnnnnnnn nnnncacgtg n                                      31


<210> 784
<211> 32
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (6)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(25)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (32)..(32)
<223> a, c, t, g, unknown or other

<400> 784
tnsccnnngg snnnnnnnnn nnnnncacgt gn                                     32


<210> 785
<211> 14
<212> DNA
<213> Homo sapiens

<400> 785
tmrcacytma twaa                                                         14


<210> 786
<211> 29
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (6)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(19)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(22)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (28)..(29)
<223> a, c, t, g, unknown or other

<400> 786
angtgnnann nnnnnnnnnc nnmggawnn                                         29


<210> 787
<211> 24
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(19)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (23)..(24)
<223> a, c, t, g, unknown or other

<400> 787
argtgtnnna atatkynnnc rcnn                                              24


<210> 788
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 788
atrsgggnnn nttrcgyaan                                                   20


<210> 789
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<400> 789
ggwatgynnn ncrcgygy                                                     18


<210> 790
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<400> 790
ggwatgynnn nnncrcgygy                                                   20


<210> 791
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(19)
<223> a, c, t, g, unknown or other

<400> 791
trgyaacnnn ncasstgnn                                                    19


<210> 792
<211> 30
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(23)
<223> a, c, t, g, unknown or other

<400> 792
aggygygann nnnnnnnnnn nnntcrtwaa                                        30


<210> 793
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<400> 793
nncgtaaaat ta                                                           12


<210> 794
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 794
nrmatatacc aataaa                                                       16


<210> 795
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 795
ntcgtaaaat gc                                                           12


<210> 796
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 796
ntcgtaaatc a                                                            11


<210> 797
<211> 14
<212> DNA
<213> Homo sapiens

<400> 797
rccggaagta atta                                                         14


<210> 798
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(3)
<223> a, c, t, g, unknown or other

<400> 798
ynnrtaaatc aatca                                                        15


<210> 799
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 799
nccggatatg can                                                          13


<210> 800
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(14)
<223> a, c, t, g, unknown or other

<400> 800
ngatgatgca atnn                                                         14


<210> 801
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 801
ngcagctgcc ggawryn                                                      17


<210> 802
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 802
ngccacgcaa yn                                                           12


<210> 803
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(17)
<223> a, c, t, g, unknown or other

<400> 803
nmatgacacg cgccmnn                                                      17


<210> 804
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 804
nmccggaacc gttr                                                         14


<210> 805
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 805
nncagctgcc ggawryn                                                      17


<210> 806
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 806
nngaaaaccg aanm                                                         14


<210> 807
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 807
nnmatcacat aaan                                                         14


<210> 808
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 808
nnmcaccgcg cccmn                                                        15


<210> 809
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(16)
<223> a, c, t, g, unknown or other

<400> 809
nnnrtaaatc acacnn                                                       16


<210> 810
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 810
ntgccggaag tn                                                           12


<210> 811
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(14)
<223> a, c, t, g, unknown or other

<400> 811
nwaaacagga agnn                                                         14


<210> 812
<211> 12
<212> DNA
<213> Homo sapiens

<400> 812
rccggaaatr sy                                                           12


<210> 813
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 813
rccggatgtt kwn                                                          13


<210> 814
<211> 13
<212> DNA
<213> Homo sapiens

<400> 814
rccggatgtt kwy                                                          13


<210> 815
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 815
rgaatgcgga agtn                                                         14


<210> 816
<211> 14
<212> DNA
<213> Homo sapiens

<400> 816
rgaatgcgga agtr                                                         14


<210> 817
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 817
rgaatgcgga tn                                                           12


<210> 818
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 818
rggtgttaat kn                                                           12


<210> 819
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(15)
<223> a, c, t, g, unknown or other

<400> 819
rmagaaaacc gaann                                                        15


<210> 820
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 820
rncggatgtt kwn                                                          13


<210> 821
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 821
rnmtgatgca atn                                                          13


<210> 822
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 822
rscggaagta ataaan                                                       16


<210> 823
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 823
rscggaagtc gtaaan                                                       16


<210> 824
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 824
rscggatgtk kn                                                           12


<210> 825
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 825
rscggatgtt gn                                                           12


<210> 826
<211> 12
<212> DNA
<213> Homo sapiens

<400> 826
rscggatgtt kw                                                           12


<210> 827
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 827
rscggatgtt kwn                                                          13


<210> 828
<211> 11
<212> DNA
<213> Homo sapiens

<400> 828
rscggtaatk r                                                            11


<210> 829
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 829
rtgcgggcgg aagtn                                                        15


<210> 830
<211> 15
<212> DNA
<213> Homo sapiens

<400> 830
rtgcgggcgg aagtr                                                        15


<210> 831
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 831
rtgcgggtaa taaan                                                        15


<210> 832
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 832
rwmaacagga agtn                                                         14


<210> 833
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(14)
<223> a, c, t, g, unknown or other

<400> 833
rwmaacagga arnn                                                         14


<210> 834
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 834
rwyaacagga agyn                                                         14


<210> 835
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 835
sgcgctaatt kn                                                           12


<210> 836
<211> 11
<212> DNA
<213> Homo sapiens

<400> 836
waacaacacm y                                                            11


<210> 837
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 837
wmscggatgt knw                                                          13


<210> 838
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<400> 838
ncacctgnnn nnmatta                                                      17


<210> 839
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<400> 839
ncacgtgnng gatta                                                        15


<210> 840
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<400> 840
ncaggtgnnn nnmatta                                                      17


<210> 841
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<400> 841
ncccgcannm ataaa                                                        15


<210> 842
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<400> 842
ncccgcannn mrtaaa                                                       16


<210> 843
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(14)
<223> a, c, t, g, unknown or other

<400> 843
nccggaagnn nnnnymatta                                                   20


<210> 844
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<400> 844
nccggaagtm atta                                                         14


<210> 845
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 845
nnatcatngt aaa                                                          13


<210> 846
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<400> 846
nnatgaygca at                                                           12


<210> 847
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 847
nnmaacaynr taaa                                                         14


<210> 848
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<400> 848
ntaatccnnw maaca                                                        15


<210> 849
<211> 11
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (3)..(3)
<223> a, c, t, g, unknown or other

<400> 849
nynatmaatc a                                                            11


<210> 850
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<400> 850
rcattccnnn nnncacgtg                                                    19


<210> 851
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(14)
<223> a, c, t, g, unknown or other

<400> 851
rcattccnnn nnnncacgtg                                                   20


<210> 852
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<400> 852
rcattccnnn yaatta                                                       16


<210> 853
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<400> 853
rcattccnnn ymatta                                                       16


<210> 854
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(12)
<223> a, c, t, g, unknown or other

<400> 854
rcattcnnnn nncatta                                                      17


<210> 855
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(11)
<223> a, c, t, g, unknown or other

<400> 855
rcattcnnnn ntaatcc                                                      17


<210> 856
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<400> 856
rcattcynnn caatta                                                       16


<210> 857
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<400> 857
rcattcynnn ncaatta                                                      17


<210> 858
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<400> 858
rcattcynnn nncatta                                                      17


<210> 859
<211> 12
<212> DNA
<213> Homo sapiens

<400> 859
rccggaaatr cc                                                           12


<210> 860
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<400> 860
rccggaannn nnnyaatta                                                    19


<210> 861
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<400> 861
rccggaannn nnyaatta                                                     18


<210> 862
<211> 13
<212> DNA
<213> Homo sapiens

<400> 862
rgaatgcgga wrt                                                          13


<210> 863
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<400> 863
rgaatgcnnr taaa                                                         14


<210> 864
<211> 11
<212> DNA
<213> Homo sapiens

<400> 864
rgaatgygtg a                                                            11


<210> 865
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<400> 865
rgaatgynna cgtg                                                         14


<210> 866
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(15)
<223> a, c, t, g, unknown or other

<400> 866
rggtgtnnnn nnnnnyattg t                                                 21


<210> 867
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<400> 867
rkrngggnna taaa                                                         14


<210> 868
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<400> 868
rncggaanna aaca                                                         14


<210> 869
<211> 13
<212> DNA
<213> Homo sapiens

<400> 869
rraatgcart aaa                                                          13


<210> 870
<211> 12
<212> DNA
<213> Homo sapiens

<400> 870
rscggaaatr cc                                                           12


<210> 871
<211> 14
<212> DNA
<213> Homo sapiens

<400> 871
rscggaagtm rtta                                                         14


<210> 872
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<400> 872
rscggaannn nggatta                                                      17


<210> 873
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<400> 873
rscggaannn nnggatta                                                     18


<210> 874
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(14)
<223> a, c, t, g, unknown or other

<400> 874
rscggaannn nnnnywttgt                                                   20


<210> 875
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<400> 875
rscggaannn nnnrtcgat                                                    19


<210> 876
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<400> 876
rscggaannn nnnyaatta                                                    19


<210> 877
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<400> 877
rscggaannn nnnywttgt                                                    19


<210> 878
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<400> 878
rscggaannn nnyaatta                                                     18


<210> 879
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<400> 879
rscggaannn nnymatta                                                     18


<210> 880
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<400> 880
rscggaannn nyaatta                                                      17


<210> 881
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 881
rscggaanya atta                                                         14


<210> 882
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 882
rscggaanyn rtaaa                                                        15


<210> 883
<211> 14
<212> DNA
<213> Homo sapiens

<400> 883
rscggaarya atta                                                         14


<210> 884
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(14)
<223> a, c, t, g, unknown or other

<400> 884
rscggawnnn nnnnymatta                                                   20


<210> 885
<211> 13
<212> DNA
<213> Homo sapiens

<400> 885
rscggawrya tta                                                          13


<210> 886
<211> 13
<212> DNA
<213> Homo sapiens

<400> 886
smggaagtmr tta                                                          13


<210> 887
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 887
symrtaaanc tgtca                                                        15


<210> 888
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (3)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 888
synrtaaann tgtca                                                        15


<210> 889
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(16)
<223> a, c, t, g, unknown or other

<400> 889
yaacggnnnn nnnnnncacg tg                                                22


<210> 890
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(17)
<223> a, c, t, g, unknown or other

<400> 890
yaacggnnnn nnnnnnncac gtg                                               23


<210> 891
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(13)
<223> a, c, t, g, unknown or other

<400> 891
yrattannnn nnncacgtg                                                    19


<210> 892
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<400> 892
nacaatrnnn ngaatgy                                                      17


<210> 893
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<400> 893
nacaatrnnn nngaatgy                                                     18


<210> 894
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 894
nacttccggy nnnngcaacs n                                                 21


<210> 895
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<400> 895
naggtgntaa tkr                                                          13


<210> 896
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<400> 896
ncacgtgnnn nncatatgn                                                    19


<210> 897
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 897
ncacgtgnnn nnscggawrn                                                   20


<210> 898
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<400> 898
ncagctgnnn nncacgtgn                                                    19


<210> 899
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 899
ncagctgnnn nnnncacgtg n                                                 21


<210> 900
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 900
nccggaagty rtaaan                                                       16


<210> 901
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 901
nccggaanca tatgn                                                        15


<210> 902
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(21)
<223> a, c, t, g, unknown or other

<400> 902
nccggaannn nnncagctgn n                                                 21


<210> 903
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 903
nccggaanya taaan                                                        15


<210> 904
<211> 24
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(17)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (24)..(24)
<223> a, c, t, g, unknown or other

<400> 904
nccggwnnnn nnnnnnnsca ttan                                              24


<210> 905
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 905
nggtgtgnng gcgcsn                                                       16


<210> 906
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 906
nggtgtgnnn ggcgcsn                                                      17


<210> 907
<211> 30
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(21)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (28)..(30)
<223> a, c, t, g, unknown or other

<400> 907
nggtgtnnnn nnnnnnnnnn nccggawnnn                                        30


<210> 908
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(18)
<223> a, c, t, g, unknown or other

<400> 908
nmatgacacn gcgccmnn                                                     18


<210> 909
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<400> 909
nnacaatnnn nnngaatgy                                                    19


<210> 910
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 910
nnaraaaacc gaawmn                                                       16


<210> 911
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 911
nnatgaygca ayn                                                          13


<210> 912
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(18)
<223> a, c, t, g, unknown or other

<400> 912
nncacgtgac mggaarnn                                                     18


<210> 913
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 913
nncacgtgnn ngcgggyn                                                     18


<210> 914
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(20)
<223> a, c, t, g, unknown or other

<400> 914
nncacgtgnn nnccggaann                                                   20


<210> 915
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(21)
<223> a, c, t, g, unknown or other

<400> 915
nncacgtgnn nnnccggaan n                                                 21


<210> 916
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(13)
<223> a, c, t, g, unknown or other

<400> 916
nncacgtgnn nnnccggawr y                                                 21


<210> 917
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(13)
<223> a, c, t, g, unknown or other

<400> 917
nncacgtgnn nnncggawry                                                   20


<210> 918
<211> 28
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(18)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (28)..(28)
<223> a, c, t, g, unknown or other

<400> 918
nncacgtgnn nnnnnnnnrt gcgggyrn                                          28


<210> 919
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(22)
<223> a, c, t, g, unknown or other

<400> 919
nncagctgnn nnnncacgtg nn                                                22


<210> 920
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (23)..(23)
<223> a, c, t, g, unknown or other

<400> 920
nncagctgnn nnnnnnatcg atn                                               23


<210> 921
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 921
nncagctgnn nnnnntaatt n                                                 21


<210> 922
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(12)
<223> a, c, t, g, unknown or other

<400> 922
nncagctgnn nntaatkr                                                     18


<210> 923
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (22)..(22)
<223> a, c, t, g, unknown or other

<400> 923
nncaggtgnn nnnmcggaar yn                                                22


<210> 924
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(16)
<223> a, c, t, g, unknown or other

<400> 924
nncggaanca ggtgnn                                                       16


<210> 925
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(19)
<223> a, c, t, g, unknown or other

<400> 925
nngattannn atgcawnnn                                                    19


<210> 926
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 926
nngtcacgcn ncattan                                                      17


<210> 927
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(17)
<223> a, c, t, g, unknown or other

<400> 927
nngtcacgnn tcattnn                                                      17


<210> 928
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 928
nnmggaarnn rtaaan                                                       16


<210> 929
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(20)
<223> a, c, t, g, unknown or other

<400> 929
nnnacgannn nnntcgtnnn                                                   20


<210> 930
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(17)
<223> a, c, t, g, unknown or other

<400> 930
nnncgggnnn ggtgtnn                                                      17


<210> 931
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 931
nnngmataac aawrrn                                                       16


<210> 932
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(22)
<223> a, c, t, g, unknown or other

<400> 932
nnnngcgcsn nnnncacgtg nn                                                22


<210> 933
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 933
nnnrtaaanc tgtn                                                         14


<210> 934
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(20)
<223> a, c, t, g, unknown or other

<400> 934
nnnttccgsn nnngcaacnn                                                   20


<210> 935
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 935
nnrngggcgg aartn                                                        15


<210> 936
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 936
nnsgcgcsnn natcgayn                                                     18


<210> 937
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<400> 937
nnsgcgcsnn nnatcgayn                                                    19


<210> 938
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(20)
<223> a, c, t, g, unknown or other

<400> 938
nnsmggacgg ayntccksnn                                                   20


<210> 939
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(22)
<223> a, c, t, g, unknown or other

<400> 939
nnymattann nnnnnggaag nn                                                22


<210> 940
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(21)
<223> a, c, t, g, unknown or other

<400> 940
nrcagctgnn nnncacgtgn n                                                 21


<210> 941
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<400> 941
nrcattcnnn nntaattrn                                                    19


<210> 942
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 942
nrcattcnnn nyaattn                                                      17


<210> 943
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(16)
<223> a, c, t, g, unknown or other

<400> 943
nrcccrnncg gaagnn                                                       16


<210> 944
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 944
nrscggaagn ngtaaan                                                      17


<210> 945
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(17)
<223> a, c, t, g, unknown or other

<400> 945
nscggaarnc acgtgnn                                                      17


<210> 946
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<400> 946
nscggaarnn nnnmattan                                                    19


<210> 947
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 947
nscggaarnn nnnnmattan                                                   20


<210> 948
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(22)
<223> a, c, t, g, unknown or other

<400> 948
nscggaarnn nnnntcacac nn                                                22


<210> 949
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(21)
<223> a, c, t, g, unknown or other

<400> 949
nscggaarnn nnntcacacn n                                                 21


<210> 950
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 950
nscggawntt acgtaan                                                      17


<210> 951
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 951
nsmggacgga yntccksn                                                     18


<210> 952
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 952
ntaatkrsnm rtaaan                                                       16


<210> 953
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 953
ntaatnrsny mrtaaan                                                      17


<210> 954
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<400> 954
ntgacrnnnn nncacgtgn                                                    19


<210> 955
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 955
ntgttgatrn gggn                                                         14


<210> 956
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(15)
<223> a, c, t, g, unknown or other

<400> 956
ntgttgncgg aarnn                                                        15


<210> 957
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(17)
<223> a, c, t, g, unknown or other

<400> 957
ntttaynncc ggaarnn                                                      17


<210> 958
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<400> 958
nymattannn nnacaatr                                                     18


<210> 959
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(20)
<223> a, c, t, g, unknown or other

<400> 959
nymattannn nncagctgnn                                                   20


<210> 960
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<400> 960
nymattannn nnnacaatr                                                    19


<210> 961
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(21)
<223> a, c, t, g, unknown or other

<400> 961
nymattannn nnncagctgn n                                                 21


<210> 962
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(22)
<223> a, c, t, g, unknown or other

<400> 962
nymattannn nnnncagctg nn                                                22


<210> 963
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(22)
<223> a, c, t, g, unknown or other

<400> 963
nymattannn nnnnnggaag nn                                                22


<210> 964
<211> 31
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(23)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (31)..(31)
<223> a, c, t, g, unknown or other

<400> 964
raggtsrnnn nnnnnnnnnn nnncggaagy n                                      31


<210> 965
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 965
rcattccnna tcgayn                                                       16


<210> 966
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<400> 966
rcattccnnn ntaatkr                                                      17


<210> 967
<211> 28
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(22)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (28)..(28)
<223> a, c, t, g, unknown or other

<400> 967
rcattcnnnn nnnnnnnnnn nngcaacn                                          28


<210> 968
<211> 29
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(23)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (29)..(29)
<223> a, c, t, g, unknown or other

<400> 968
rcattcnnnn nnnnnnnnnn nnngcaacn                                         29


<210> 969
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(11)
<223> a, c, t, g, unknown or other

<400> 969
rcattcnnnn ntaatkr                                                      17


<210> 970
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 970
rcattcynnn ncaaggtcan                                                   20


<210> 971
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<400> 971
rcattcynnn ntaattr                                                      17


<210> 972
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<400> 972
rccggaannn nnatcgatn                                                    19


<210> 973
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 973
rccggaannn nnnatcgatn                                                   20


<210> 974
<211> 24
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(17)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (24)..(24)
<223> a, c, t, g, unknown or other

<400> 974
rccggannnn nnnnnnnaca cctn                                              24


<210> 975
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (23)..(23)
<223> a, c, t, g, unknown or other

<400> 975
rccggannnn nnnnnntaat ccn                                               23


<210> 976
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (22)..(22)
<223> a, c, t, g, unknown or other

<400> 976
rccggannnn nnnnntaatc cn                                                22


<210> 977
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 977
rccggannnn nnnntaatcc n                                                 21


<210> 978
<211> 12
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 978
rccggawgtk kn                                                           12


<210> 979
<211> 12
<212> DNA
<213> Homo sapiens

<400> 979
rccggawgtk kw                                                           12


<210> 980
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 980
rgaatgcgga arynnntccn                                                   20


<210> 981
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 981
rgaatscgga agyn                                                         14


<210> 982
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 982
rggtgtnnnn nnnngaatgy n                                                 21


<210> 983
<211> 12
<212> DNA
<213> Homo sapiens

<400> 983
rggtgytaat wr                                                           12


<210> 984
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(16)
<223> a, c, t, g, unknown or other

<400> 984
rgtgtnnnaa tatknn                                                       16


<210> 985
<211> 14
<212> DNA
<213> Homo sapiens

<400> 985
rgwatgttaa tccs                                                         14


<210> 986
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 986
rkcacgtgnn nmcatatgkn                                                   20


<210> 987
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(21)
<223> a, c, t, g, unknown or other

<400> 987
rkrnrggcgg aarcggaagn n                                                 21


<210> 988
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 988
rmatwccgga wrn                                                          13


<210> 989
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (22)..(22)
<223> a, c, t, g, unknown or other

<400> 989
rncggaannn nnnnnngcaa cn                                                22


<210> 990
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 990
rncgganntt gcgcaan                                                      17


<210> 991
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 991
rrgtgtnnnn nnnnacaatr n                                                 21


<210> 992
<211> 12
<212> DNA
<213> Homo sapiens

<400> 992
rscggaaatr cm                                                           12


<210> 993
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 993
rscggaagnn gtaaan                                                       16


<210> 994
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 994
rscggaagtn gtaaan                                                       16


<210> 995
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 995
rscggaanca cgtgn                                                        15


<210> 996
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(21)
<223> a, c, t, g, unknown or other

<400> 996
rscggaannn nnncacgtgn n                                                 21


<210> 997
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(22)
<223> a, c, t, g, unknown or other

<400> 997
rscggaannn nnnncacgtg nn                                                22


<210> 998
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(14)
<223> a, c, t, g, unknown or other

<400> 998
rscggaannn nnnntaatkr                                                   20


<210> 999
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 999
rscggaannn nnnrtcgatn                                                   20


<210> 1000
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<400> 1000
rscggaannn nnyaattan                                                    19


<210> 1001
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 1001
rscggaannr ymaacan                                                      17


<210> 1002
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 1002
rscggaanrw maacan                                                       16


<210> 1003
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 1003
rscggaarca ggtgn                                                        15


<210> 1004
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 1004
rscggaaryn ntaaan                                                       16


<210> 1005
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<400> 1005
rscggannca tatgk                                                        15


<210> 1006
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 1006
rscggatgtt rtn                                                          13


<210> 1007
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 1007
rscggawnnn nnnacaatrn                                                   20


<210> 1008
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 1008
rscggawnnn nnnnacaatr n                                                 21


<210> 1009
<211> 11
<212> DNA
<213> Homo sapiens

<400> 1009
rscggwaatk r                                                            11


<210> 1010
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(8)
<223> a, c, t, g, unknown or other

<400> 1010
rsgtgnnnaa cgk                                                          13


<210> 1011
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 1011
rtaaacaynr taaan                                                        15


<210> 1012
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 1012
rtaaacmgga aryn                                                         14


<210> 1013
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(13)
<223> a, c, t, g, unknown or other

<400> 1013
rtaaatangg gnn                                                          13


<210> 1014
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 1014
rtcacgysnc cggawn                                                       16


<210> 1015
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(16)
<223> a, c, t, g, unknown or other

<400> 1015
rtgcgggnag gtgnnn                                                       16


<210> 1016
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<400> 1016
rtgcgggnna tcgatr                                                       16


<210> 1017
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 1017
rtgcgggnnn nnnncacgtg n                                                 21


<210> 1018
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<400> 1018
rtgcgggnnn tcgatr                                                       16


<210> 1019
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 1019
rtmaacagga agtn                                                         14


<210> 1020
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(14)
<223> a, c, t, g, unknown or other

<400> 1020
rtmaacagga arnn                                                         14


<210> 1021
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 1021
rtmaacagga wrn                                                          13


<210> 1022
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 1022
rtrcgggtaa taaan                                                        15


<210> 1023
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (4)..(5)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 1023
rtrnnggcgg aagtn                                                        15


<210> 1024
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 1024
rtrygggcgg aarkn                                                        15


<210> 1025
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(17)
<223> a, c, t, g, unknown or other

<400> 1025
rwcacgtgnn cggaann                                                      17


<210> 1026
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(21)
<223> a, c, t, g, unknown or other

<400> 1026
rwmaacaggn nnnnnttccn n                                                 21


<210> 1027
<211> 26
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(18)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (25)..(26)
<223> a, c, t, g, unknown or other

<400> 1027
sgcgccnnnn nnnnnnnnca gctgnn                                            26


<210> 1028
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 1028
sgcgcnnnnn cggaagn                                                      17


<210> 1029
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (22)..(22)
<223> a, c, t, g, unknown or other

<400> 1029
sgcgcnnnnn nnnnncggaa gn                                                22


<210> 1030
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (23)..(23)
<223> a, c, t, g, unknown or other

<400> 1030
sgcgcnnnnn nnnnnncgga agn                                               23


<210> 1031
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(16)
<223> a, c, t, g, unknown or other

<400> 1031
sgtcacgcnt cattnn                                                       16


<210> 1032
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 1032
symattannn nnnrgcaacn                                                   20


<210> 1033
<211> 13
<212> DNA
<213> Homo sapiens

<400> 1033
wtgmataaca atr                                                          13


<210> 1034
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 1034
ynattanrgg tgtgan                                                       16


<210> 1035
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<400> 1035
ncacgtgnnn nnncatwcc                                                    19


<210> 1036
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(14)
<223> a, c, t, g, unknown or other

<400> 1036
ncacgtgnnn nnnncatwcc                                                   20


<210> 1037
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(15)
<223> a, c, t, g, unknown or other

<400> 1037
ncagctgnnn nnnnntrcgg g                                                 21


<210> 1038
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(14)
<223> a, c, t, g, unknown or other

<400> 1038
ncagctgnnn nnnntrcggg                                                   20


<210> 1039
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(14)
<223> a, c, t, g, unknown or other

<400> 1039
nccggaannn nnnnmatwcc                                                   20


<210> 1040
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<400> 1040
ncrcgtgnnn ggatta                                                       16


<210> 1041
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (5)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(17)
<223> a, c, t, g, unknown or other

<400> 1041
ngtgnnnnma tatknnnaca cc                                                22


<210> 1042
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(12)
<223> a, c, t, g, unknown or other

<400> 1042
nncrcgtgnn nnggatta                                                     18


<210> 1043
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<400> 1043
nnmattagtc acgcwtsrnt g                                                 21


<210> 1044
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(3)
<223> a, c, t, g, unknown or other

<400> 1044
nnntatgcag ygtka                                                        15


<210> 1045
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(16)
<223> a, c, t, g, unknown or other

<400> 1045
nntcccgcnn nccnnnggc                                                    19


<210> 1046
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (5)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(16)
<223> a, c, t, g, unknown or other

<400> 1046
nsccnnnrgg cannnnymat ta                                                22


<210> 1047
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 1047
nscggacgga watccgsnt                                                    19


<210> 1048
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(11)
<223> a, c, t, g, unknown or other

<400> 1048
nscggannnn nggmtta                                                      17


<210> 1049
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(12)
<223> a, c, t, g, unknown or other

<400> 1049
nscggannnn nnggmtta                                                     18


<210> 1050
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<400> 1050
ntrngggnnn cacgtg                                                       16


<210> 1051
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 1051
ntttatnrnt maaca                                                        15


<210> 1052
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(18)
<223> a, c, t, g, unknown or other

<400> 1052
rcatwccnnn nnnnnynnta aa                                                22


<210> 1053
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(10)
<223> a, c, t, g, unknown or other

<400> 1053
rcatwcnnnn ggatta                                                       16


<210> 1054
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(11)
<223> a, c, t, g, unknown or other

<400> 1054
rcatwcnnnn nggatta                                                      17


<210> 1055
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(12)
<223> a, c, t, g, unknown or other

<400> 1055
rcatwcnnnn nnaggtca                                                     18


<210> 1056
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<400> 1056
rcatwcynnn nntaatcc                                                     18


<210> 1057
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<400> 1057
rcatwcynnn ntaatcc                                                      17


<210> 1058
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(12)
<223> a, c, t, g, unknown or other

<400> 1058
rggtgtkann nnggatta                                                     18


<210> 1059
<211> 31
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(24)
<223> a, c, t, g, unknown or other

<400> 1059
rmatatkcnn nnnnnnnnnn nnnnrwmaac a                                      31


<210> 1060
<211> 30
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(23)
<223> a, c, t, g, unknown or other

<400> 1060
rmatatkcnn nnnnnnnnnn nnnrwmaaca                                        30


<210> 1061
<211> 28
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(21)
<223> a, c, t, g, unknown or other

<400> 1061
rmatatkcnn nnnnnnnnnn nrwmaaca                                          28


<210> 1062
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<400> 1062
rncggawgtm atta                                                         14


<210> 1063
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(15)
<223> a, c, t, g, unknown or other

<400> 1063
rscggaannn nnnnncatwc c                                                 21


<210> 1064
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 1064
rscggaants rcgtga                                                       16


<210> 1065
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 1065
rscggaasng rtcgata                                                      17


<210> 1066
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (11)..(18)
<223> a, c, t, g, unknown or other

<400> 1066
rscggwaatk nnnnnnnnma tta                                               23


<210> 1067
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<400> 1067
rscggwannn nymatta                                                      17


<210> 1068
<211> 14
<212> DNA
<213> Homo sapiens

<400> 1068
rsmggawgya atta                                                         14


<210> 1069
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 1069
rtaaacwnat waaa                                                         14


<210> 1070
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<400> 1070
rtgnkggcgg awg                                                          13


<210> 1071
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<400> 1071
rtrcgggnng atta                                                         14


<210> 1072
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<400> 1072
rtrcgggnnn nttacgtaa                                                    19


<210> 1073
<211> 16
<212> DNA
<213> Homo sapiens

<400> 1073
rwmaacasym rtwaaa                                                       16


<210> 1074
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (4)..(6)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(11)
<223> a, c, t, g, unknown or other

<400> 1074
sccnnnggcn nyaatta                                                      17


<210> 1075
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 1075
syaattanwg gtgyga                                                       16


<210> 1076
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(11)
<223> a, c, t, g, unknown or other

<400> 1076
wtwtgcatan ntaatta                                                      17


<210> 1077
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<400> 1077
ynrcacstcg twaa                                                         14


<210> 1078
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(15)
<223> a, c, t, g, unknown or other

<400> 1078
naacggnnat ygann                                                        15


<210> 1079
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(18)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (22)..(23)
<223> a, c, t, g, unknown or other

<400> 1079
natcgatnnn nngcctnngg snn                                               23


<210> 1080
<211> 25
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(20)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (24)..(25)
<223> a, c, t, g, unknown or other

<400> 1080
natcgatnnn nnnngcctnn ggsnn                                             25


<210> 1081
<211> 26
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(21)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (25)..(26)
<223> a, c, t, g, unknown or other

<400> 1081
natcgatnnn nnnnngcctn nggsnn                                            26


<210> 1082
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(14)
<223> a, c, t, g, unknown or other

<400> 1082
natcratnnn nnnnaacaat rs                                                22


<210> 1083
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(15)
<223> a, c, t, g, unknown or other

<400> 1083
natcratnnn nnnnnaacaa trs                                               23


<210> 1084
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 1084
natttrcnnn acaatrn                                                      17


<210> 1085
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(17)
<223> a, c, t, g, unknown or other

<400> 1085
ncacgtgnny aacsgnn                                                      17


<210> 1086
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 1086
ncaggtgngw atgyn                                                        15


<210> 1087
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<400> 1087
ncagstgnnn nnngtaatkr                                                   20


<210> 1088
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(14)
<223> a, c, t, g, unknown or other

<400> 1088
ncagstgnnn nnnngtaatk r                                                 21


<210> 1089
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (23)..(23)
<223> a, c, t, g, unknown or other

<400> 1089
ncasstgknn nnnnnncacg tgn                                               23


<210> 1090
<211> 24
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(17)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (24)..(24)
<223> a, c, t, g, unknown or other

<400> 1090
ncasstgknn nnnnnnncac gtgn                                              24


<210> 1091
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 1091
nccggaagyn ncntagcaac s                                                 21


<210> 1092
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(21)
<223> a, c, t, g, unknown or other

<400> 1092
nccggaannn nnncacgygn n                                                 21


<210> 1093
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 1093
nccggaantn rtaaan                                                       16


<210> 1094
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<400> 1094
nccggannca sstgy                                                        15


<210> 1095
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<400> 1095
ngataasnnn rgwatgy                                                      17


<210> 1096
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (6)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 1096
ngcctnnggs nncggaagyn                                                   20


<210> 1097
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(19)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (23)..(23)
<223> a, c, t, g, unknown or other

<400> 1097
nggtgtgnng gcgcsnnnnc rmn                                               23


<210> 1098
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<400> 1098
nncacgtgnn nnrgmttan                                                    19


<210> 1099
<211> 24
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(17)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (24)..(24)
<223> a, c, t, g, unknown or other

<400> 1099
nncagctgnn nnnnnnnaty gatn                                              24


<210> 1100
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 1100
nncggawgym attan                                                        15


<210> 1101
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 1101
nnggamggat ktccgsn                                                      17


<210> 1102
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 1102
nngtmaatan gggyr                                                        15


<210> 1103
<211> 24
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (6)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (23)..(24)
<223> a, c, t, g, unknown or other

<400> 1103
nngygnnnnn nnnwaacaac acnn                                              24


<210> 1104
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 1104
nngygysaca ttccn                                                        15


<210> 1105
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 1105
nnmggaartg ckggn                                                        15


<210> 1106
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(17)
<223> a, c, t, g, unknown or other

<400> 1106
nnmrtaaant macacnn                                                      17


<210> 1107
<211> 25
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(19)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (25)..(25)
<223> a, c, t, g, unknown or other

<400> 1107
nnnmggaann nnntccnnnr caacn                                             25


<210> 1108
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 1108
nnnrtaaann tnacacyn                                                     18


<210> 1109
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(3)
<223> a, c, t, g, unknown or other

<400> 1109
nnnrtaaawa tygayy                                                       16


<210> 1110
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<400> 1110
nnrgyaacnt cacgtgay                                                     18


<210> 1111
<211> 29
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(21)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (28)..(29)
<223> a, c, t, g, unknown or other

<400> 1111
nrgtgtnann nnnnnnnnnn nccggaann                                         29


<210> 1112
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 1112
nrgyaacnnn catatgkn                                                     18


<210> 1113
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 1113
nrtcratanc ggaaryn                                                      17


<210> 1114
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 1114
nrtmaacmgg aaryn                                                        15


<210> 1115
<211> 24
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (5)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(18)
<223> a, c, t, g, unknown or other

<400> 1115
nsccnnnrgg cannnnnnta atkr                                              24


<210> 1116
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (5)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(17)
<223> a, c, t, g, unknown or other

<400> 1116
nsccnnnrgg cannnnntaa tkr                                               23


<210> 1117
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 1117
ntcacacmnn natcratn                                                     18


<210> 1118
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 1118
ntgacagnta atcratan                                                     18


<210> 1119
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (3)..(5)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(23)
<223> a, c, t, g, unknown or other

<400> 1119
ntnnnggcgg aagnnnttcc nnn                                               23


<210> 1120
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(23)
<223> a, c, t, g, unknown or other

<400> 1120
ntrngggcgg aagnnnttcc nnn                                               23


<210> 1121
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 1121
ntrygggnnn tggcgggarn                                                   20


<210> 1122
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 1122
nymrtaaana tygatn                                                       16


<210> 1123
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (23)..(23)
<223> a, c, t, g, unknown or other

<400> 1123
rattccnnnn nnnnnncass tgn                                               23


<210> 1124
<211> 29
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(19)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (29)..(29)
<223> a, c, t, g, unknown or other

<400> 1124
rcatwccnnn nnnnnnnnnr wgcgtgacn                                         29


<210> 1125
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(21)
<223> a, c, t, g, unknown or other

<400> 1125
rcatwccnnn nnntttaynn n                                                 21


<210> 1126
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 1126
rccggaannn nnnratcrat n                                                 21


<210> 1127
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (15)..(16)
<223> a, c, t, g, unknown or other

<400> 1127
rccggaarca sstgnn                                                       16


<210> 1128
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 1128
rccgganrnn cggwatkn                                                     18


<210> 1129
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 1129
rggtgntaak ccn                                                          13


<210> 1130
<211> 25
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (11)..(19)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (24)..(25)
<223> a, c, t, g, unknown or other

<400> 1130
rggtgntaat nnnnnnnnnc asynn                                             25


<210> 1131
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 1131
rgwatgytaa tkn                                                          13


<210> 1132
<211> 13
<212> DNA
<213> Homo sapiens

<400> 1132
rgwatgytaa tkr                                                          13


<210> 1133
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 1133
rncggaagnn nnncasstgn                                                   20


<210> 1134
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 1134
rncggaanyn rtwaan                                                       16


<210> 1135
<211> 29
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (6)..(18)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (29)..(29)
<223> a, c, t, g, unknown or other

<400> 1135
rngtgnnnnn nnnnnnnnrc rccggawsn                                         29


<210> 1136
<211> 29
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(21)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (27)..(29)
<223> a, c, t, g, unknown or other

<400> 1136
rrgtgtknnn nnnnnnnnnn ncmggannn                                         29


<210> 1137
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 1137
rrtcratnnn cggaaryn                                                     18


<210> 1138
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(16)
<223> a, c, t, g, unknown or other

<400> 1138
rscggaanca gstgnn                                                       16


<210> 1139
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(16)
<223> a, c, t, g, unknown or other

<400> 1139
rscggaanca sctgnn                                                       16


<210> 1140
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 1140
rscggaanca sstgn                                                        15


<210> 1141
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<400> 1141
rscggaannn nnggmttan                                                    19


<210> 1142
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 1142
rscggaasng rtcgatan                                                     18


<210> 1143
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 1143
rscgganntt gcgyaan                                                      17


<210> 1144
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 1144
rscggawrca sstgn                                                        15


<210> 1145
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 1145
rscggwaatn nnnattan                                                     18


<210> 1146
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<400> 1146
rscggwaatn nnnnattan                                                    19


<210> 1147
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 1147
rscggwaatn nnyattan                                                     18


<210> 1148
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 1148
rsmggaantt gcgyaan                                                      17


<210> 1149
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 1149
rsmggaartn ntaaan                                                       16


<210> 1150
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<400> 1150
rtaaacannn nnatcratn                                                    19


<210> 1151
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 1151
rtmaacatrn gggn                                                         14


<210> 1152
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 1152
rtmaatamgg gyrn                                                         14


<210> 1153
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 1153
rtmrcgtgac ggawgn                                                       16


<210> 1154
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(22)
<223> a, c, t, g, unknown or other

<400> 1154
rtrcgggnnn nnnnywttgt nn                                                22


<210> 1155
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<400> 1155
rtrcgggnnn nnntaatkr                                                    19


<210> 1156
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<400> 1156
rtrcgggnnn nntaatkr                                                     18


<210> 1157
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<400> 1157
rtrcgggnnn nntaattr                                                     18


<210> 1158
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<400> 1158
rtrcgggnnn nrnacaawn                                                    19


<210> 1159
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 1159
rtrcgggnnn rnacaawn                                                     18


<210> 1160
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 1160
rtrcgggsga ttan                                                         14


<210> 1161
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 1161
rtrngggtnn taaan                                                        15


<210> 1162
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 1162
rtrsgggnaa ttan                                                         14


<210> 1163
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(15)
<223> a, c, t, g, unknown or other

<400> 1163
rtrsgggnna attan                                                        15


<210> 1164
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<400> 1164
rtrsgggnnn attgtky                                                      17


<210> 1165
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<400> 1165
rtrsgggnnt aatkr                                                        15


<210> 1166
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (12)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(23)
<223> a, c, t, g, unknown or other

<400> 1166
rtrskggcgg annnnnatcc nnn                                               23


<210> 1167
<211> 24
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (12)..(17)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (22)..(24)
<223> a, c, t, g, unknown or other

<400> 1167
rtrskggcgg annnnnnatc cnnn                                              24


<210> 1168
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 1168
symrtaaana tygatn                                                       16


<210> 1169
<211> 19
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (9)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<400> 1169
symrtaaann nncasstgn                                                    19


<210> 1170
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (14)..(14)
<223> a, c, t, g, unknown or other

<400> 1170
wgttkmcgga wrtn                                                         14


<210> 1171
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 1171
ynattagtca cgcwtsrntr                                                   20


<210> 1172
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(15)
<223> a, c, t, g, unknown or other

<400> 1172
ncasstgnnn nnnnnrtrcg gg                                                22


<210> 1173
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(19)
<223> a, c, t, g, unknown or other

<400> 1173
nggtgtgnnn ggcgcsnnnc rc                                                22


<210> 1174
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(11)
<223> a, c, t, g, unknown or other

<400> 1174
nncggangnn ntwaa                                                        15


<210> 1175
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other

<400> 1175
nncggawgtn rtwaa                                                        15


<210> 1176
<211> 13
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 1176
ntatkcagyg tna                                                          13


<210> 1177
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(17)
<223> a, c, t, g, unknown or other

<400> 1177
ratcratnnn nnnnnnnrgy aac                                               23


<210> 1178
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(16)
<223> a, c, t, g, unknown or other

<400> 1178
ratcratnnn nnnnnnrgya ac                                                22


<210> 1179
<211> 28
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(21)
<223> a, c, t, g, unknown or other

<400> 1179
rcatwccnnn nnnnnnnnnn nrtmaaca                                          28


<210> 1180
<211> 27
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(20)
<223> a, c, t, g, unknown or other

<400> 1180
rcatwccnnn nnnnnnnnnn rtmaaca                                           27


<210> 1181
<211> 26
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(19)
<223> a, c, t, g, unknown or other

<400> 1181
rcatwccnnn nnnnnnnnnr tmaaca                                            26


<210> 1182
<211> 25
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(18)
<223> a, c, t, g, unknown or other

<400> 1182
rcatwccnnn nnnnnnnnrt maaca                                             25


<210> 1183
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 1183
rcatwcynnn ntaatyrnat ta                                                22


<210> 1184
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 1184
rscggaacya cgcwysantg                                                   20


<210> 1185
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(16)
<223> a, c, t, g, unknown or other

<400> 1185
rscggaanna ggygyna                                                      17


<210> 1186
<211> 16
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<400> 1186
rscggaannr tmaaya                                                       16


<210> 1187
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<400> 1187
rscggaanrt maaya                                                        15


<210> 1188
<211> 15
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<400> 1188
rtrcgggnnc asstg                                                        15


<210> 1189
<211> 14
<212> DNA
<213> Homo sapiens

<400> 1189
rwmaacaycr twaa                                                         14


<210> 1190
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (4)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(13)
<223> a, c, t, g, unknown or other

<400> 1190
sccnnnnggc atngtwaa                                                     18


<210> 1191
<211> 27
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(22)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (26)..(27)
<223> a, c, t, g, unknown or other

<400> 1191
natygatnnn nnnnnngcct nnggsnn                                           27


<210> 1192
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(14)
<223> a, c, t, g, unknown or other

<400> 1192
ncasstgnnn nnnncsgttr                                                   20


<210> 1193
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(15)
<223> a, c, t, g, unknown or other

<400> 1193
ncasstgnnn nnnnncsgtt r                                                 21


<210> 1194
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(16)
<223> a, c, t, g, unknown or other

<400> 1194
ncasstgnnn nnnnnncsgt tr                                                22


<210> 1195
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 1195
ncasstgnnn nnnyaacsgy n                                                 21


<210> 1196
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 1196
ncasstgnnn nnyaacsgyn                                                   20


<210> 1197
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (13)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (23)..(23)
<223> a, c, t, g, unknown or other

<400> 1197
nccataywng gwnnnnatcr atn                                               23


<210> 1198
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (22)..(22)
<223> a, c, t, g, unknown or other

<400> 1198
nggtgtgnnn nntmattwgc rn                                                22


<210> 1199
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(18)
<223> a, c, t, g, unknown or other

<400> 1199
nrgcaacnnn crcgygnn                                                     18


<210> 1200
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(20)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (23)..(23)
<223> a, c, t, g, unknown or other

<400> 1200
nrgyaacnnn nncctwwwnn ggn                                               23


<210> 1201
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 1201
nscgganntt rcgyaan                                                      17


<210> 1202
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(15)
<223> a, c, t, g, unknown or other

<400> 1202
nttrcgyaan nnnnnggaat gy                                                22


<210> 1203
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 1203
rcattccnnc rcgygyn                                                      17


<210> 1204
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 1204
rcattccnnn nncrcgygyn                                                   20


<210> 1205
<211> 29
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(19)
<223> a, c, t, g, unknown or other

<400> 1205
rggtgngann nnnnnntnnc accggaagy                                         29


<210> 1206
<211> 24
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (7)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (15)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(19)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (23)..(24)
<223> a, c, t, g, unknown or other

<400> 1206
rggtgtnnng gcgsnntnnc rsnn                                              24


<210> 1207
<211> 28
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(18)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (28)..(28)
<223> a, c, t, g, unknown or other

<400> 1207
rgtgtkrnnn nnnnnnnncn cmggaarn                                          28


<210> 1208
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (13)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(23)
<223> a, c, t, g, unknown or other

<400> 1208
rgwatscgga tgnnnntcck nnn                                               23


<210> 1209
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (10)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 1209
rrcrcgygyn nnnsgcgcsn                                                   20


<210> 1210
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 1210
rscggaannr tmaayan                                                      17


<210> 1211
<211> 17
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 1211
rscggawntt rcgyaan                                                      17


<210> 1212
<211> 25
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(18)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (24)..(25)
<223> a, c, t, g, unknown or other

<400> 1212
rtgnkggcgg awgnnnnntc cggnn                                             25


<210> 1213
<211> 24
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(17)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (23)..(24)
<223> a, c, t, g, unknown or other

<400> 1213
rtgnkggcgg awgnnnntcc ggnn                                              24


<210> 1214
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(20)
<223> a, c, t, g, unknown or other

<400> 1214
rtrcgggnnn nnnatcratn                                                   20


<210> 1215
<211> 20
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(20)
<223> a, c, t, g, unknown or other

<400> 1215
rtrnkggtnn ngcacgygnn                                                   20


<210> 1216
<211> 26
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (4)..(6)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(20)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (25)..(26)
<223> a, c, t, g, unknown or other

<400> 1216
sccnnnggsn nnggaagnnn ttccnn                                            26


<210> 1217
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (11)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 1217
srcrcgygsy nnnnsgcgcs n                                                 21


<210> 1218
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<400> 1218
wngtgykama twcy                                                         14


<210> 1219
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(13)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (22)..(22)
<223> a, c, t, g, unknown or other

<400> 1219
mtrsgggnnn nnnttrcgya an                                                22


<210> 1220
<211> 21
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(12)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 1220
mtrsgggnnn nnttrcgyaa n                                                 21


<210> 1221
<211> 30
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(19)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (23)..(23)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (25)..(26)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (30)..(30)
<223> a, c, t, g, unknown or other

<400> 1221
nggtgtnnnn nnnnnnnnnc acntnntwan                                        30


<210> 1222
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (22)..(23)
<223> a, c, t, g, unknown or other

<400> 1222
ngygytaayn nnnnntnaca cnn                                               23


<210> 1223
<211> 24
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (19)..(21)
<223> a, c, t, g, unknown or other

<400> 1223
nncrcgygnn nnnnnsccnn nggs                                              24


<210> 1224
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(14)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(20)
<223> a, c, t, g, unknown or other

<400> 1224
nncrcgygnn nnnnsccnnn ggs                                               23


<210> 1225
<211> 24
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (6)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(19)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (23)..(24)
<223> a, c, t, g, unknown or other

<400> 1225
nngygnnnng gcgcsnnnnc rcnn                                              24


<210> 1226
<211> 30
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (9)..(11)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(26)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (30)..(30)
<223> a, c, t, g, unknown or other

<400> 1226
nnntatgcnn ngygannnnn nnnnnncrcn                                        30


<210> 1227
<211> 24
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(17)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (23)..(24)
<223> a, c, t, g, unknown or other

<400> 1227
nnsygncnaa cnnnnnncac rcnn                                              24


<210> 1228
<211> 24
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(17)
<223> a, c, t, g, unknown or other

<400> 1228
nttrcgyaan nnnnnnnrgw atgy                                              24


<210> 1229
<211> 23
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(16)
<223> a, c, t, g, unknown or other

<400> 1229
nttrcgyaan nnnnnnrgwa tgy                                               23


<210> 1230
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (10)..(15)
<223> a, c, t, g, unknown or other

<400> 1230
nttrcgyaan nnnnnrgwat gy                                                22


<210> 1231
<211> 28
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(16)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(19)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (24)..(24)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (28)..(28)
<223> a, c, t, g, unknown or other

<400> 1231
rggtgwknnn nnnnnntnnc rtrngggn                                          28


<210> 1232
<211> 18
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (18)..(18)
<223> a, c, t, g, unknown or other

<400> 1232
rgwatgynnt trcgyaan                                                     18


<210> 1233
<211> 22
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (1)..(1)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (5)..(6)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (14)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (22)..(22)
<223> a, c, t, g, unknown or other

<400> 1233
ngygnnamat wcynntmrcr cn                                                22


<210> 1234
<211> 90
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<400> 1234
Met Gly Lys Asn Lys Leu Leu His Pro Ser Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Leu Pro Xaa Asp Ala Ser Val Ser Gly Lys Pro Gln Tyr Met 
            20                  25                  30          


Val Leu Val Pro Ser Leu Leu His Xaa Glu Xaa Xaa Glu Lys Gly Cys 
        35                  40                  45              


Val Leu Leu Ser Tyr Leu Asn Glu Xaa Val Xaa Val Ser Ala Ser Leu 
    50                  55                  60                  


Glu Ser Val Arg Gly Asn Arg Ser Leu Phe Xaa Asp Leu Glu Ala Glu 
65                  70                  75                  80  


Asn Asp Val Leu His Cys Val Ala Phe Ala 
                85                  90  


<210> 1235
<211> 168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<400> 1235
Met Gly Lys Asn Lys Leu Leu His Pro Ser Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Leu Pro Xaa Asp Ala Ser Val Ser Gly Lys Pro Gln Tyr Met 
            20                  25                  30          


Val Leu Val Pro Ser Leu Leu His Xaa Glu Xaa Xaa Glu Lys Gly Cys 
        35                  40                  45              


Val Leu Leu Ser Tyr Leu Asn Glu Xaa Val Xaa Val Ser Ala Ser Leu 
    50                  55                  60                  


Glu Ser Val Arg Gly Asn Arg Ser Leu Phe Xaa Asp Leu Glu Ala Glu 
65                  70                  75                  80  


Asn Asp Val Leu His Cys Val Ala Phe Ala Val Pro Lys Ser Ser Ser 
                85                  90                  95      


Asn Glu Glu Val Met Phe Leu Xaa Val Gln Val Lys Gly Pro Xaa Gln 
            100                 105                 110         


Glu Phe Lys Lys Arg Xaa Xaa Val Met Val Lys Asn Glu Asp Ser Leu 
        115                 120                 125             


Val Phe Val Gln Xaa Asp Lys Ser Ile Tyr Lys Pro Gly Gln Xaa Val 
    130                 135                 140                 


Lys Phe Arg Val Val Ser Met Asp Glu Asn Phe His Pro Leu Asn Glu 
145                 150                 155                 160 


Leu Ile Pro Leu Val Tyr Ile Gln 
                165             


<210> 1236
<211> 1474
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1106)..(1106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1117)..(1117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1218)..(1218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1224)..(1224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1268)..(1268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1270)..(1270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1272)..(1272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1317)..(1317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1347)..(1347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1359)..(1359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1395)..(1395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1426)..(1426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1432)..(1432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<400> 1236
Met Gly Lys Asn Lys Leu Leu His Pro Ser Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Leu Pro Xaa Asp Ala Ser Val Ser Gly Lys Pro Gln Tyr Met 
            20                  25                  30          


Val Leu Val Pro Ser Leu Leu His Xaa Glu Xaa Xaa Glu Lys Gly Cys 
        35                  40                  45              


Val Leu Leu Ser Tyr Leu Asn Glu Xaa Val Xaa Val Ser Ala Ser Leu 
    50                  55                  60                  


Glu Ser Val Arg Gly Asn Arg Ser Leu Phe Xaa Asp Leu Glu Ala Glu 
65                  70                  75                  80  


Asn Asp Val Leu His Cys Val Ala Phe Ala Val Pro Lys Ser Ser Ser 
                85                  90                  95      


Asn Glu Glu Val Met Phe Leu Xaa Val Gln Val Lys Gly Pro Xaa Gln 
            100                 105                 110         


Glu Phe Lys Lys Arg Xaa Xaa Val Met Val Lys Asn Glu Asp Ser Leu 
        115                 120                 125             


Val Phe Val Gln Xaa Asp Lys Ser Ile Tyr Lys Pro Gly Gln Xaa Val 
    130                 135                 140                 


Lys Phe Arg Val Val Ser Met Asp Glu Asn Phe His Pro Leu Asn Glu 
145                 150                 155                 160 


Leu Ile Pro Leu Val Tyr Ile Gln Asp Pro Lys Gly Asn Arg Ile Ala 
                165                 170                 175     


Gln Trp Gln Ser Phe Gln Leu Glu Gly Gly Leu Lys Gln Phe Ser Phe 
            180                 185                 190         


Pro Leu Ser Ser Glu Pro Phe Gln Gly Ser Tyr Lys Val Val Val Gln 
        195                 200                 205             


Lys Lys Ser Gly Gly Arg Xaa Glu His Pro Phe Xaa Val Glu Glu Phe 
    210                 215                 220                 


Val Leu Pro Lys Phe Glu Val Gln Val Xaa Val Pro Lys Ile Ile Xaa 
225                 230                 235                 240 


Ile Leu Glu Glu Glu Met Asn Val Ser Val Cys Gly Leu Tyr Xaa Tyr 
                245                 250                 255     


Gly Lys Pro Val Pro Gly His Val Xaa Val Ser Ile Cys Arg Lys Tyr 
            260                 265                 270         


Ser Asp Ala Ser Asp Cys His Gly Glu Asp Ser Gln Ala Phe Cys Glu 
        275                 280                 285             


Lys Phe Ser Gly Gln Leu Asn Ser His Gly Cys Phe Tyr Gln Gln Val 
    290                 295                 300                 


Lys Xaa Lys Val Phe Gln Leu Lys Arg Lys Glu Tyr Glu Met Lys Leu 
305                 310                 315                 320 


His Xaa Glu Ala Gln Ile Gln Glu Glu Gly Xaa Val Val Glu Leu Xaa 
                325                 330                 335     


Gly Arg Gln Ser Ser Glu Ile Xaa Arg Xaa Ile Xaa Lys Leu Ser Phe 
            340                 345                 350         


Val Lys Val Asp Ser His Phe Arg Gln Gly Ile Pro Phe Phe Gly Gln 
        355                 360                 365             


Val Arg Leu Val Asp Gly Lys Gly Val Pro Ile Pro Asn Lys Val Ile 
    370                 375                 380                 


Phe Ile Arg Gly Asn Glu Ala Asn Tyr Tyr Ser Asn Ala Xaa Xaa Asp 
385                 390                 395                 400 


Glu His Gly Leu Val Gln Phe Ser Ile Asn Xaa Xaa Asn Val Met Gly 
                405                 410                 415     


Xaa Ser Leu Xaa Val Arg Val Asn Tyr Lys Asp Arg Ser Pro Cys Tyr 
            420                 425                 430         


Gly Tyr Gln Trp Val Ser Glu Glu His Glu Glu Ala His His Xaa Ala 
        435                 440                 445             


Tyr Leu Val Phe Ser Pro Ser Lys Ser Phe Val His Leu Glu Pro Met 
    450                 455                 460                 


Ser His Glu Leu Pro Cys Gly His Xaa Gln Xaa Val Gln Ala His Tyr 
465                 470                 475                 480 


Ile Leu Asn Gly Gly Xaa Leu Leu Gly Leu Lys Lys Leu Ser Phe Tyr 
                485                 490                 495     


Tyr Leu Ile Met Ala Lys Gly Gly Ile Val Arg Xaa Gly Xaa His Gly 
            500                 505                 510         


Leu Leu Val Lys Gln Glu Asp Met Lys Gly His Phe Ser Ile Ser Ile 
        515                 520                 525             


Pro Val Lys Ser Asp Ile Ala Pro Val Ala Arg Leu Leu Ile Tyr Ala 
    530                 535                 540                 


Val Leu Pro Xaa Gly Asp Val Ile Gly Asp Ser Ala Lys Tyr Asp Val 
545                 550                 555                 560 


Glu Asn Cys Leu Ala Asn Lys Val Asp Leu Ser Phe Ser Pro Ser Gln 
                565                 570                 575     


Ser Leu Pro Ala Ser His Ala His Leu Arg Val Xaa Ala Ala Pro Gln 
            580                 585                 590         


Ser Val Cys Ala Leu Arg Ala Val Asp Gln Ser Val Leu Leu Met Lys 
        595                 600                 605             


Pro Asp Ala Glu Leu Ser Ala Ser Ser Val Tyr Asn Leu Leu Pro Glu 
    610                 615                 620                 


Lys Asp Leu Xaa Gly Phe Pro Gly Pro Leu Asn Asp Gln Asp Asn Glu 
625                 630                 635                 640 


Asp Cys Ile Asn Arg His Asn Val Tyr Ile Asn Gly Ile Xaa Tyr Xaa 
                645                 650                 655     


Pro Val Ser Ser Xaa Asn Glu Lys Asp Met Tyr Ser Phe Leu Glu Asp 
            660                 665                 670         


Met Gly Leu Lys Ala Phe Xaa Asn Ser Lys Ile Arg Lys Pro Lys Met 
        675                 680                 685             


Cys Pro Gln Leu Gln Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg 
    690                 695                 700                 


Val Gly Phe Tyr Glu Ser Asp Val Met Gly Arg Gly His Ala Arg Leu 
705                 710                 715                 720 


Val His Val Glu Glu Pro His Xaa Glu Xaa Val Arg Lys Tyr Phe Pro 
                725                 730                 735     


Glu Xaa Trp Ile Trp Asp Leu Val Val Val Asn Ser Ala Gly Val Ala 
            740                 745                 750         


Glu Val Gly Val Xaa Val Pro Asp Xaa Ile Xaa Glu Trp Lys Ala Gly 
        755                 760                 765             


Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu Gly Ile Ser Ser Xaa Ala 
    770                 775                 780                 


Ser Leu Arg Ala Phe Gln Pro Phe Phe Val Glu Leu Xaa Met Pro Tyr 
785                 790                 795                 800 


Ser Val Ile Arg Gly Glu Ala Phe Xaa Leu Lys Ala Xaa Val Leu Asn 
                805                 810                 815     


Tyr Leu Pro Lys Cys Ile Arg Val Ser Val Gln Leu Glu Ala Ser Pro 
            820                 825                 830         


Ala Phe Leu Ala Val Pro Val Glu Lys Glu Gln Ala Pro His Cys Ile 
        835                 840                 845             


Cys Ala Asn Gly Arg Gln Xaa Val Ser Trp Ala Val Xaa Pro Lys Ser 
    850                 855                 860                 


Leu Gly Asn Val Asn Phe Xaa Val Ser Ala Glu Ala Leu Glu Ser Gln 
865                 870                 875                 880 


Glu Leu Cys Gly Xaa Glu Val Pro Ser Val Pro Glu His Gly Arg Lys 
                885                 890                 895     


Asp Xaa Val Ile Lys Pro Leu Leu Val Glu Pro Glu Gly Leu Glu Lys 
            900                 905                 910         


Glu Xaa Xaa Phe Asn Ser Leu Leu Cys Pro Ser Gly Gly Glu Val Ser 
        915                 920                 925             


Glu Glu Leu Ser Leu Lys Leu Pro Pro Asn Val Val Glu Glu Ser Ala 
    930                 935                 940                 


Arg Ala Ser Val Ser Val Leu Gly Asp Ile Leu Gly Ser Ala Met Gln 
945                 950                 955                 960 


Asn Xaa Gln Asn Leu Leu Gln Met Pro Tyr Gly Cys Gly Glu Gln Asn 
                965                 970                 975     


Met Val Leu Phe Ala Pro Asn Ile Tyr Val Leu Asp Tyr Leu Asn Glu 
            980                 985                 990         


Xaa Gln Gln Leu Xaa Pro Glu Ile  Lys Ser Lys Ala Ile  Gly Tyr Leu 
        995                 1000                 1005             


Asn Xaa  Gly Tyr Gln Arg Gln  Leu Asn Tyr Lys His  Tyr Asp Gly 
    1010                 1015                 1020             


Ser Tyr  Ser Xaa Phe Gly Glu  Arg Tyr Gly Arg Asn  Gln Gly Asn 
    1025                 1030                 1035             


Xaa Trp  Leu Xaa Ala Phe Val  Leu Lys Xaa Phe Ala  Gln Ala Arg 
    1040                 1045                 1050             


Ala Tyr  Ile Phe Ile Asp Glu  Ala His Ile Xaa Gln  Ala Leu Ile 
    1055                 1060                 1065             


Trp Leu  Ser Gln Arg Gln Lys  Asp Asn Gly Cys Phe  Arg Ser Ser 
    1070                 1075                 1080             


Gly Ser  Leu Leu Asn Asn Ala  Ile Lys Gly Gly Val  Glu Asp Glu 
    1085                 1090                 1095             


Val Xaa  Leu Ser Ala Tyr Ile  Xaa Ile Ala Leu Leu  Glu Ile Pro 
    1100                 1105                 1110             


Leu Xaa  Val Xaa His Pro Val  Val Arg Asn Ala Leu  Phe Cys Leu 
    1115                 1120                 1125             


Glu Ser  Ala Trp Lys Xaa Ala  Gln Glu Gly Asp His  Gly Ser His 
    1130                 1135                 1140             


Val Tyr  Xaa Lys Ala Leu Leu  Ala Tyr Ala Phe Ala  Leu Ala Gly 
    1145                 1150                 1155             


Asn Gln  Asp Lys Arg Lys Glu  Val Leu Lys Ser Leu  Asn Glu Glu 
    1160                 1165                 1170             


Ala Val  Lys Lys Asp Asn Ser  Val His Trp Glu Arg  Pro Gln Lys 
    1175                 1180                 1185             


Pro Lys  Ala Pro Val Gly His  Phe Tyr Glu Pro Gln  Ala Pro Ser 
    1190                 1195                 1200             


Ala Glu  Val Glu Met Xaa Ser  Tyr Val Leu Leu Ala  Tyr Leu Xaa 
    1205                 1210                 1215             


Ala Gln  Pro Ala Pro Xaa Ser  Glu Asp Leu Xaa Ser  Ala Xaa Asn 
    1220                 1225                 1230             


Ile Val  Lys Trp Ile Xaa Lys  Gln Gln Asn Ala Gln  Gly Gly Phe 
    1235                 1240                 1245             


Ser Ser  Xaa Gln Asp Xaa Val  Val Ala Leu His Ala  Leu Ser Lys 
    1250                 1255                 1260             


Tyr Gly  Ala Ala Xaa Phe Xaa  Arg Xaa Gly Lys Ala  Ala Gln Val 
    1265                 1270                 1275             


Xaa Ile  Gln Ser Ser Gly Xaa  Phe Ser Ser Lys Phe  Gln Val Asp 
    1280                 1285                 1290             


Asn Asn  Asn Arg Leu Leu Leu  Gln Gln Val Ser Leu  Pro Glu Leu 
    1295                 1300                 1305             


Pro Gly  Glu Tyr Ser Met Lys  Val Xaa Gly Glu Gly  Cys Val Tyr 
    1310                 1315                 1320             


Leu Gln  Xaa Ser Leu Lys Tyr  Asn Ile Leu Pro Glu  Lys Glu Glu 
    1325                 1330                 1335             


Phe Pro  Phe Ala Leu Gly Val  Gln Xaa Leu Pro Gln  Xaa Cys Asp 
    1340                 1345                 1350             


Glu Pro  Lys Ala His Xaa Ser  Phe Gln Ile Ser Leu  Ser Val Ser 
    1355                 1360                 1365             


Tyr Xaa  Gly Ser Arg Ser Ala  Ser Asn Met Ala Ile  Val Asp Val 
    1370                 1375                 1380             


Lys Met  Val Ser Gly Phe Ile  Pro Leu Lys Pro Xaa  Val Lys Met 
    1385                 1390                 1395             


Leu Glu  Arg Ser Asn His Val  Ser Arg Xaa Glu Val  Ser Ser Asn 
    1400                 1405                 1410             


His Val  Leu Ile Tyr Leu Asp  Lys Val Ser Asn Gln  Xaa Leu Ser 
    1415                 1420                 1425             


Leu Phe  Phe Xaa Val Leu Gln  Asp Val Pro Val Arg  Asp Leu Lys 
    1430                 1435                 1440             


Pro Ala  Ile Val Lys Val Tyr  Asp Tyr Tyr Glu Xaa  Asp Glu Phe 
    1445                 1450                 1455             


Ala Ile  Ala Glu Tyr Asn Ala  Pro Cys Ser Lys Asp  Leu Gly Asn 
    1460                 1465                 1470             


Ala 
    


<210> 1237
<211> 73
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 1237
Asn Gly Gly Xaa Leu Leu Gly Leu Lys Lys Leu Ser Phe Tyr Tyr Leu 
1               5                   10                  15      


Ile Met Ala Lys Gly Gly Ile Val Arg Xaa Gly Xaa His Gly Leu Leu 
            20                  25                  30          


Val Lys Gln Glu Asp Met Lys Gly His Phe Ser Ile Ser Ile Pro Val 
        35                  40                  45              


Lys Ser Asp Ile Ala Pro Val Ala Arg Phe Xaa Xaa Cys Tyr Gln Lys 
    50                  55                  60                  


Arg Xaa Ser Leu Ala Ser Leu Gly Leu 
65                  70              


<210> 1238
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 1238
Ala Ala Ala Glu Ala Ser Leu Asn Lys Ser Lys Ser Ala Xaa Xaa Xaa 
1               5                   10                  15      


Pro Ser Gly Ser Pro Arg Xaa Ser Gln Gln Asn Val Tyr Asn Pro Ser 
            20                  25                  30          


Glu Gly Ser Xaa Trp Asn Pro Phe Asp Asp Asp Asn Phe Ser Lys Leu 
        35                  40                  45              


Xaa Ala Glu Glu Leu Leu Asn Lys Asp Phe Ala Lys Leu Gly Glu Gly 
    50                  55                  60                  


Lys His Pro Glu Lys Leu Gly Gly Ser Ala Glu Ser Leu Ile Pro Gly 
65                  70                  75                  80  


Phe Gln Ser Xaa Gln Gly Asp Ala Phe Ala Xaa Xaa Ser Phe Ser Ala 
                85                  90                  95      


Gly Xaa Val 
            


<210> 1239
<211> 674
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<400> 1239
Met Lys Lys Phe Phe Asp Ser Arg Arg Glu Gln Gly Gly Ser Gly Leu 
1               5                   10                  15      


Gly Ser Gly Ser Ser Gly Gly Gly Gly Ser Xaa Ser Gly Leu Gly Ser 
            20                  25                  30          


Gly Tyr Ile Gly Arg Val Phe Gly Ile Gly Arg Gln Gln Val Xaa Val 
        35                  40                  45              


Asp Glu Val Leu Ala Glu Gly Gly Phe Ala Ile Val Phe Leu Val Arg 
    50                  55                  60                  


Xaa Ser Asn Gly Met Lys Cys Ala Leu Lys Arg Met Phe Val Asn Asn 
65                  70                  75                  80  


Glu His Asp Leu Gln Val Cys Lys Arg Glu Ile Gln Ile Met Arg Asp 
                85                  90                  95      


Leu Ser Gly His Lys Asn Ile Val Gly Tyr Ile Asp Ser Ser Ile Asn 
            100                 105                 110         


Asn Val Ser Ser Gly Asp Val Trp Glu Val Leu Ile Leu Met Asp Phe 
        115                 120                 125             


Cys Arg Gly Gly Gln Val Val Asn Leu Met Asn Gln Arg Leu Gln Xaa 
    130                 135                 140                 


Gly Phe Xaa Glu Asn Glu Val Leu Gln Ile Phe Cys Asp Xaa Cys Glu 
145                 150                 155                 160 


Ala Val Ala Arg Leu His Gln Cys Lys Xaa Pro Ile Ile His Arg Asp 
                165                 170                 175     


Leu Lys Val Glu Asn Ile Leu Leu His Asp Arg Gly His Tyr Val Leu 
            180                 185                 190         


Cys Asp Phe Gly Ser Ala Xaa Asn Lys Phe Gln Asn Pro Gln Xaa Glu 
        195                 200                 205             


Gly Val Asn Ala Val Glu Asp Glu Ile Lys Lys Tyr Xaa Xaa Leu Ser 
    210                 215                 220                 


Tyr Arg Ala Pro Glu Met Val Asn Leu Tyr Ser Gly Lys Ile Ile Xaa 
225                 230                 235                 240 


Xaa Lys Ala Asp Ile Trp Ala Leu Gly Cys Leu Leu Tyr Lys Leu Cys 
                245                 250                 255     


Tyr Phe Xaa Leu Pro Phe Gly Glu Ser Gln Val Ala Ile Cys Asp Gly 
            260                 265                 270         


Asn Phe Xaa Ile Pro Asp Asn Ser Arg Tyr Ser Gln Asp Met His Cys 
        275                 280                 285             


Leu Ile Arg Tyr Met Leu Glu Pro Asp Pro Asp Lys Arg Pro Asp Ile 
    290                 295                 300                 


Tyr Gln Val Ser Tyr Phe Ser Phe Lys Leu Leu Lys Lys Glu Cys Pro 
305                 310                 315                 320 


Ile Pro Asn Val Gln Asn Ser Pro Ile Pro Ala Lys Leu Pro Glu Pro 
                325                 330                 335     


Val Lys Ala Ser Glu Ala Ala Ala Lys Lys Xaa Gln Pro Lys Ala Arg 
            340                 345                 350         


Leu Xaa Asp Pro Ile Pro Xaa Xaa Glu Xaa Ser Ile Ala Pro Arg Gln 
        355                 360                 365             


Arg Pro Lys Ala Gly Gln Xaa Gln Pro Asn Pro Gly Ile Leu Pro Ile 
    370                 375                 380                 


Gln Pro Ala Leu Xaa Pro Arg Lys Arg Ala Xaa Val Gln Pro Pro Pro 
385                 390                 395                 400 


Gln Ala Ala Gly Ser Ser Asn Gln Pro Gly Leu Leu Ala Ser Val Pro 
                405                 410                 415     


Gln Pro Lys Pro Gln Ala Pro Pro Ser Gln Pro Leu Pro Gln Xaa Gln 
            420                 425                 430         


Ala Lys Gln Pro Gln Ala Pro Pro Xaa Pro Gln Gln Xaa Pro Ser Xaa 
        435                 440                 445             


Gln Ala Gln Gly Leu Pro Ala Gln Ala Gln Ala Xaa Pro Gln His Gln 
    450                 455                 460                 


Gln Gln Leu Phe Leu Lys Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro 
465                 470                 475                 480 


Ala Gln Gln Gln Pro Ala Gly Xaa Phe Tyr Gln Gln Gln Gln Ala Gln 
                485                 490                 495     


Xaa Gln Gln Phe Gln Ala Val His Pro Ala Xaa Gln Lys Pro Ala Ile 
            500                 505                 510         


Ala Gln Phe Pro Val Val Ser Gln Gly Gly Ser Gln Gln Gln Leu Met 
        515                 520                 525             


Gln Asn Phe Tyr Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    530                 535                 540                 


Gln Gln Leu Ala Xaa Ala Leu His Gln Gln Gln Leu Met Xaa Gln Gln 
545                 550                 555                 560 


Ala Ala Leu Gln Gln Lys Pro Xaa Met Ala Ala Gly Gln Gln Pro Gln 
                565                 570                 575     


Pro Gln Pro Ala Ala Ala Pro Gln Pro Ala Pro Ala Gln Glu Pro Ala 
            580                 585                 590         


Ile Gln Ala Pro Val Arg Gln Gln Pro Lys Val Gln Xaa Xaa Pro Pro 
        595                 600                 605             


Pro Ala Val Gln Gly Gln Lys Val Gly Ser Leu Xaa Pro Pro Ser Ser 
    610                 615                 620                 


Pro Lys Xaa Gln Arg Ala Gly His Arg Arg Ile Leu Ser Asp Val Xaa 
625                 630                 635                 640 


His Ser Ala Val Phe Gly Val Pro Ala Ser Lys Ser Xaa Gln Leu Leu 
                645                 650                 655     


Gln Ala Ala Ala Ala Glu Ala Glu Leu Leu Asp Pro Gly Arg Gln Xaa 
            660                 665                 670         


Leu Gln 
        


<210> 1240
<211> 863
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<400> 1240
Met Lys Lys Phe Phe Asp Ser Arg Arg Glu Gln Gly Gly Ser Gly Leu 
1               5                   10                  15      


Gly Ser Gly Ser Ser Gly Gly Gly Gly Ser Xaa Ser Gly Leu Gly Ser 
            20                  25                  30          


Gly Tyr Ile Gly Arg Val Phe Gly Ile Gly Arg Gln Gln Val Xaa Val 
        35                  40                  45              


Asp Glu Val Leu Ala Glu Gly Gly Phe Ala Ile Val Phe Leu Val Arg 
    50                  55                  60                  


Xaa Ser Asn Gly Met Lys Cys Ala Leu Lys Arg Met Phe Val Asn Asn 
65                  70                  75                  80  


Glu His Asp Leu Gln Val Cys Lys Arg Glu Ile Gln Ile Met Arg Asp 
                85                  90                  95      


Leu Ser Gly His Lys Asn Ile Val Gly Tyr Ile Asp Ser Ser Ile Asn 
            100                 105                 110         


Asn Val Ser Ser Gly Asp Val Trp Glu Val Leu Ile Leu Met Asp Phe 
        115                 120                 125             


Cys Arg Gly Gly Gln Val Val Asn Leu Met Asn Gln Arg Leu Gln Xaa 
    130                 135                 140                 


Gly Phe Xaa Glu Asn Glu Val Leu Gln Ile Phe Cys Asp Xaa Cys Glu 
145                 150                 155                 160 


Ala Val Ala Arg Leu His Gln Cys Lys Xaa Pro Ile Ile His Arg Asp 
                165                 170                 175     


Leu Lys Val Glu Asn Ile Leu Leu His Asp Arg Gly His Tyr Val Leu 
            180                 185                 190         


Cys Asp Phe Gly Ser Ala Xaa Asn Lys Phe Gln Asn Pro Gln Xaa Glu 
        195                 200                 205             


Gly Val Asn Ala Val Glu Asp Glu Ile Lys Lys Tyr Xaa Xaa Leu Ser 
    210                 215                 220                 


Tyr Arg Ala Pro Glu Met Val Asn Leu Tyr Ser Gly Lys Ile Ile Xaa 
225                 230                 235                 240 


Xaa Lys Ala Asp Ile Trp Ala Leu Gly Cys Leu Leu Tyr Lys Leu Cys 
                245                 250                 255     


Tyr Phe Xaa Leu Pro Phe Gly Glu Ser Gln Val Ala Ile Cys Asp Gly 
            260                 265                 270         


Asn Phe Xaa Ile Pro Asp Asn Ser Arg Tyr Ser Gln Asp Met His Cys 
        275                 280                 285             


Leu Ile Arg Tyr Met Leu Glu Pro Asp Pro Asp Lys Arg Pro Asp Ile 
    290                 295                 300                 


Tyr Gln Val Ser Tyr Phe Ser Phe Lys Leu Leu Lys Lys Glu Cys Pro 
305                 310                 315                 320 


Ile Pro Asn Val Gln Asn Ser Pro Ile Pro Ala Lys Leu Pro Glu Pro 
                325                 330                 335     


Val Lys Ala Ser Glu Ala Ala Ala Lys Lys Xaa Gln Pro Lys Ala Arg 
            340                 345                 350         


Leu Xaa Asp Pro Ile Pro Xaa Xaa Glu Xaa Ser Ile Ala Pro Arg Gln 
        355                 360                 365             


Arg Pro Lys Ala Gly Gln Xaa Gln Pro Asn Pro Gly Ile Leu Pro Ile 
    370                 375                 380                 


Gln Pro Ala Leu Xaa Pro Arg Lys Arg Ala Xaa Val Gln Pro Pro Pro 
385                 390                 395                 400 


Gln Ala Ala Gly Ser Ser Asn Gln Pro Gly Leu Leu Ala Ser Val Pro 
                405                 410                 415     


Gln Pro Lys Pro Gln Ala Pro Pro Ser Gln Pro Leu Pro Gln Xaa Gln 
            420                 425                 430         


Ala Lys Gln Pro Gln Ala Pro Pro Xaa Pro Gln Gln Xaa Pro Ser Xaa 
        435                 440                 445             


Gln Ala Gln Gly Leu Pro Ala Gln Ala Gln Ala Xaa Pro Gln His Gln 
    450                 455                 460                 


Gln Gln Leu Phe Leu Lys Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro 
465                 470                 475                 480 


Ala Gln Gln Gln Pro Ala Gly Xaa Phe Tyr Gln Gln Gln Gln Ala Gln 
                485                 490                 495     


Xaa Gln Gln Phe Gln Ala Val His Pro Ala Xaa Gln Lys Pro Ala Ile 
            500                 505                 510         


Ala Gln Phe Pro Val Val Ser Gln Gly Gly Ser Gln Gln Gln Leu Met 
        515                 520                 525             


Gln Asn Phe Tyr Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    530                 535                 540                 


Gln Gln Leu Ala Xaa Ala Leu His Gln Gln Gln Leu Met Xaa Gln Gln 
545                 550                 555                 560 


Ala Ala Leu Gln Gln Lys Pro Xaa Met Ala Ala Gly Gln Gln Pro Gln 
                565                 570                 575     


Pro Gln Pro Ala Ala Ala Pro Gln Pro Ala Pro Ala Gln Glu Pro Ala 
            580                 585                 590         


Ile Gln Ala Pro Val Arg Gln Gln Pro Lys Val Gln Xaa Xaa Pro Pro 
        595                 600                 605             


Pro Ala Val Gln Gly Gln Lys Val Gly Ser Leu Xaa Pro Pro Ser Ser 
    610                 615                 620                 


Pro Lys Xaa Gln Arg Ala Gly His Arg Arg Ile Leu Ser Asp Val Xaa 
625                 630                 635                 640 


His Ser Ala Val Phe Gly Val Pro Ala Ser Lys Ser Xaa Gln Leu Leu 
                645                 650                 655     


Gln Ala Ala Ala Ala Glu Ala Ser Leu Asn Lys Ser Lys Ser Ala Xaa 
            660                 665                 670         


Xaa Xaa Pro Ser Gly Ser Pro Arg Xaa Ser Gln Gln Asn Val Tyr Asn 
        675                 680                 685             


Pro Ser Glu Gly Ser Xaa Trp Asn Pro Phe Asp Asp Asp Asn Phe Ser 
    690                 695                 700                 


Lys Leu Xaa Ala Glu Glu Leu Leu Asn Lys Asp Phe Ala Lys Leu Gly 
705                 710                 715                 720 


Glu Gly Lys His Pro Glu Lys Leu Gly Gly Ser Ala Glu Ser Leu Ile 
                725                 730                 735     


Pro Gly Phe Gln Ser Xaa Gln Gly Asp Ala Phe Ala Xaa Xaa Ser Phe 
            740                 745                 750         


Ser Ala Gly Xaa Ala Glu Lys Arg Lys Gly Gly Gln Xaa Val Asp Ser 
        755                 760                 765             


Gly Leu Pro Leu Leu Ser Val Ser Asp Pro Phe Ile Pro Leu Gln Val 
    770                 775                 780                 


Pro Asp Ala Pro Glu Lys Leu Ile Glu Gly Leu Lys Ser Pro Asp Xaa 
785                 790                 795                 800 


Ser Leu Leu Leu Pro Asp Leu Leu Pro Met Xaa Asp Pro Phe Gly Ser 
                805                 810                 815     


Xaa Ser Asp Ala Val Ile Gly Lys Val Ile Ile Ser Val Ser Ser Val 
            820                 825                 830         


Met His Asp Met Cys Ala Cys Phe Lys Asn Asp Lys Tyr Leu Val Asn 
        835                 840                 845             


Gln Ser Leu Gly Asn Ser Pro Ala Xaa Pro Glu Ala Lys Ala Ile 
    850                 855                 860             


<210> 1241
<211> 961
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<400> 1241
Met Lys Lys Phe Phe Asp Ser Arg Arg Glu Gln Gly Gly Ser Gly Leu 
1               5                   10                  15      


Gly Ser Gly Ser Ser Gly Gly Gly Gly Ser Xaa Ser Gly Leu Gly Ser 
            20                  25                  30          


Gly Tyr Ile Gly Arg Val Phe Gly Ile Gly Arg Gln Gln Val Xaa Val 
        35                  40                  45              


Asp Glu Val Leu Ala Glu Gly Gly Phe Ala Ile Val Phe Leu Val Arg 
    50                  55                  60                  


Xaa Ser Asn Gly Met Lys Cys Ala Leu Lys Arg Met Phe Val Asn Asn 
65                  70                  75                  80  


Glu His Asp Leu Gln Val Cys Lys Arg Glu Ile Gln Ile Met Arg Asp 
                85                  90                  95      


Leu Ser Gly His Lys Asn Ile Val Gly Tyr Ile Asp Ser Ser Ile Asn 
            100                 105                 110         


Asn Val Ser Ser Gly Asp Val Trp Glu Val Leu Ile Leu Met Asp Phe 
        115                 120                 125             


Cys Arg Gly Gly Gln Val Val Asn Leu Met Asn Gln Arg Leu Gln Xaa 
    130                 135                 140                 


Gly Phe Xaa Glu Asn Glu Val Leu Gln Ile Phe Cys Asp Xaa Cys Glu 
145                 150                 155                 160 


Ala Val Ala Arg Leu His Gln Cys Lys Xaa Pro Ile Ile His Arg Asp 
                165                 170                 175     


Leu Lys Val Glu Asn Ile Leu Leu His Asp Arg Gly His Tyr Val Leu 
            180                 185                 190         


Cys Asp Phe Gly Ser Ala Xaa Asn Lys Phe Gln Asn Pro Gln Xaa Glu 
        195                 200                 205             


Gly Val Asn Ala Val Glu Asp Glu Ile Lys Lys Tyr Xaa Xaa Leu Ser 
    210                 215                 220                 


Tyr Arg Ala Pro Glu Met Val Asn Leu Tyr Ser Gly Lys Ile Ile Xaa 
225                 230                 235                 240 


Xaa Lys Ala Asp Ile Trp Ala Leu Gly Cys Leu Leu Tyr Lys Leu Cys 
                245                 250                 255     


Tyr Phe Xaa Leu Pro Phe Gly Glu Ser Gln Val Ala Ile Cys Asp Gly 
            260                 265                 270         


Asn Phe Xaa Ile Pro Asp Asn Ser Arg Tyr Ser Gln Asp Met His Cys 
        275                 280                 285             


Leu Ile Arg Tyr Met Leu Glu Pro Asp Pro Asp Lys Arg Pro Asp Ile 
    290                 295                 300                 


Tyr Gln Val Ser Tyr Phe Ser Phe Lys Leu Leu Lys Lys Glu Cys Pro 
305                 310                 315                 320 


Ile Pro Asn Val Gln Asn Ser Pro Ile Pro Ala Lys Leu Pro Glu Pro 
                325                 330                 335     


Val Lys Ala Ser Glu Ala Ala Ala Lys Lys Xaa Gln Pro Lys Ala Arg 
            340                 345                 350         


Leu Xaa Asp Pro Ile Pro Xaa Xaa Glu Xaa Ser Ile Ala Pro Arg Gln 
        355                 360                 365             


Arg Pro Lys Ala Gly Gln Xaa Gln Pro Asn Pro Gly Ile Leu Pro Ile 
    370                 375                 380                 


Gln Pro Ala Leu Xaa Pro Arg Lys Arg Ala Xaa Val Gln Pro Pro Pro 
385                 390                 395                 400 


Gln Ala Ala Gly Ser Ser Asn Gln Pro Gly Leu Leu Ala Ser Val Pro 
                405                 410                 415     


Gln Pro Lys Pro Gln Ala Pro Pro Ser Gln Pro Leu Pro Gln Xaa Gln 
            420                 425                 430         


Ala Lys Gln Pro Gln Ala Pro Pro Xaa Pro Gln Gln Xaa Pro Ser Xaa 
        435                 440                 445             


Gln Ala Gln Gly Leu Pro Ala Gln Ala Gln Ala Xaa Pro Gln His Gln 
    450                 455                 460                 


Gln Gln Leu Phe Leu Lys Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro 
465                 470                 475                 480 


Ala Gln Gln Gln Pro Ala Gly Xaa Phe Tyr Gln Gln Gln Gln Ala Gln 
                485                 490                 495     


Xaa Gln Gln Phe Gln Ala Val His Pro Ala Xaa Gln Lys Pro Ala Ile 
            500                 505                 510         


Ala Gln Phe Pro Val Val Ser Gln Gly Gly Ser Gln Gln Gln Leu Met 
        515                 520                 525             


Gln Asn Phe Tyr Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    530                 535                 540                 


Gln Gln Leu Ala Xaa Ala Leu His Gln Gln Gln Leu Met Xaa Gln Gln 
545                 550                 555                 560 


Ala Ala Leu Gln Gln Lys Pro Xaa Met Ala Ala Gly Gln Gln Pro Gln 
                565                 570                 575     


Pro Gln Pro Ala Ala Ala Pro Gln Pro Ala Pro Ala Gln Glu Pro Ala 
            580                 585                 590         


Ile Gln Ala Pro Val Arg Gln Gln Pro Lys Val Gln Xaa Xaa Pro Pro 
        595                 600                 605             


Pro Ala Val Gln Gly Gln Lys Val Gly Ser Leu Xaa Pro Pro Ser Ser 
    610                 615                 620                 


Pro Lys Xaa Gln Arg Ala Gly His Arg Arg Ile Leu Ser Asp Val Xaa 
625                 630                 635                 640 


His Ser Ala Val Phe Gly Val Pro Ala Ser Lys Ser Xaa Gln Leu Leu 
                645                 650                 655     


Gln Ala Ala Ala Ala Glu Ala Ser Leu Asn Lys Ser Lys Ser Ala Xaa 
            660                 665                 670         


Xaa Xaa Pro Ser Gly Ser Pro Arg Xaa Ser Gln Gln Asn Val Tyr Asn 
        675                 680                 685             


Pro Ser Glu Gly Ser Xaa Trp Asn Pro Phe Asp Asp Asp Asn Phe Ser 
    690                 695                 700                 


Lys Leu Xaa Ala Glu Glu Leu Leu Asn Lys Asp Phe Ala Lys Leu Gly 
705                 710                 715                 720 


Glu Gly Lys His Pro Glu Lys Leu Gly Gly Ser Ala Glu Ser Leu Ile 
                725                 730                 735     


Pro Gly Phe Gln Ser Xaa Gln Gly Asp Ala Phe Ala Xaa Xaa Ser Phe 
            740                 745                 750         


Ser Ala Gly Xaa Ala Glu Lys Arg Lys Gly Gly Gln Xaa Val Asp Ser 
        755                 760                 765             


Gly Leu Pro Leu Leu Ser Val Ser Asp Pro Phe Ile Pro Leu Gln Val 
    770                 775                 780                 


Pro Asp Ala Pro Glu Lys Leu Ile Glu Gly Leu Lys Ser Pro Asp Xaa 
785                 790                 795                 800 


Ser Leu Leu Leu Pro Asp Leu Leu Pro Met Xaa Asp Pro Phe Gly Ser 
                805                 810                 815     


Xaa Ser Asp Ala Val Ile Glu Lys Ala Asp Val Ala Val Glu Ser Leu 
            820                 825                 830         


Ile Pro Gly Leu Glu Pro Pro Val Pro Gln Arg Leu Pro Ser Gln Xaa 
        835                 840                 845             


Glu Ser Val Xaa Ser Asn Arg Xaa Asp Ser Leu Xaa Gly Glu Asp Ser 
    850                 855                 860                 


Leu Leu Asp Cys Ser Leu Leu Ser Asn Pro Xaa Xaa Asp Leu Leu Glu 
865                 870                 875                 880 


Glu Phe Ala Pro Xaa Ala Ile Ser Ala Pro Val His Lys Ala Ala Glu 
                885                 890                 895     


Asp Ser Asn Leu Ile Ser Gly Phe Asp Val Pro Glu Gly Ser Asp Lys 
            900                 905                 910         


Val Ala Glu Asp Glu Phe Asp Pro Ile Pro Val Leu Ile Xaa Lys Asn 
        915                 920                 925             


Pro Gln Gly Gly His Ser Arg Asn Ser Ser Gly Ser Ser Glu Ser Ser 
    930                 935                 940                 


Leu Pro Asn Leu Ala Arg Ser Leu Leu Leu Val Asp Gln Leu Ile Asp 
945                 950                 955                 960 


Leu 
    


<210> 1242
<211> 511
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(490)
<223> Selenocysteine

<400> 1242
Xaa Gln Leu Leu Gln Ala Ala Ala Ala Glu Ala Ser Leu Asn Lys Ser 
1               5                   10                  15      


Lys Ser Ala Xaa Xaa Xaa Pro Ser Gly Ser Pro Arg Xaa Ser Gln Gln 
            20                  25                  30          


Asn Val Tyr Asn Pro Ser Glu Gly Ser Xaa Trp Asn Pro Phe Asp Asp 
        35                  40                  45              


Asp Asn Phe Ser Lys Leu Xaa Ala Glu Glu Leu Leu Asn Lys Asp Phe 
    50                  55                  60                  


Ala Lys Leu Gly Glu Gly Lys His Pro Glu Lys Leu Gly Gly Ser Ala 
65                  70                  75                  80  


Glu Ser Leu Ile Pro Gly Phe Gln Ser Xaa Gln Gly Asp Ala Phe Ala 
                85                  90                  95      


Xaa Xaa Ser Phe Ser Ala Gly Xaa Ala Glu Lys Arg Lys Gly Gly Gln 
            100                 105                 110         


Xaa Val Asp Ser Gly Leu Pro Leu Leu Ser Val Ser Asp Pro Phe Ile 
        115                 120                 125             


Pro Leu Gln Val Pro Asp Ala Pro Asp Leu Gln Arg Glu Ser Asn Pro 
    130                 135                 140                 


Cys Pro Val Ile Xaa Val Glu His Phe Lys Glu Ser Leu Gly Val Lys 
145                 150                 155                 160 


Gly Leu Pro Leu Tyr Pro Asp Pro Ser Arg Val Pro Gly Xaa Lys Xaa 
                165                 170                 175     


Gln Asn Asn Leu Glu Ser Asp Tyr Leu Ala Arg Asp Gly Pro Ser Ser 
            180                 185                 190         


Asn Ser Ser Phe His Ser Ser Glu Glu Glu Gly Xaa Asp Leu Glu Gly 
        195                 200                 205             


Asp Met Leu Asp Cys Ser Gly Ser Arg Pro Leu Leu Met Glu Ser Glu 
    210                 215                 220                 


Glu Glu Asp Glu Ser Cys Arg Pro Pro Pro Gly Lys Leu Gly Gly Ala 
225                 230                 235                 240 


Val Pro Phe Ala Pro Pro Glu Val Ser Pro Glu Gln Ala Lys Xaa Val 
                245                 250                 255     


Gln Gly Gly Arg Lys Asn Gln Phe Gln Ala Phe Xaa Gln Pro Ala Xaa 
            260                 265                 270         


Asp Gly Leu Ser Glu Pro Asp Val Phe Ala Ile Ala Pro Phe Arg Ser 
        275                 280                 285             


Ser Arg Val Pro Asn Asp Asp Met Asp Ile Phe Ser Lys Ala Pro Phe 
    290                 295                 300                 


Val Ser Lys Ser Ser Met Ala Pro Ser Gln Pro Glu Glu Ser Asp Val 
305                 310                 315                 320 


Phe Leu Arg Ala Pro Phe Xaa Lys Lys Lys Ser Met Glu Glu Leu Xaa 
                325                 330                 335     


Val Ile Gln Cys Xaa Ser Gln Glu Leu Pro Ala Gln Xaa Gly Leu Leu 
            340                 345                 350         


Ser Gln Xaa Gly Asp Val Pro Leu Pro Ala Gly Arg Glu Arg Ala Val 
        355                 360                 365             


Tyr Xaa Ser Val Gln Ala Gln Tyr Ser Xaa Ala Gly Phe Val Gln Gln 
    370                 375                 380                 


Ser Asn Leu Leu Ser His Ser Val Gln Ala Ala Asp His Leu Asp Ser 
385                 390                 395                 400 


Ile Ser Pro Arg Gly Ser Cys Leu Glu Ser Gly Gly His Ser Asn Asp 
                405                 410                 415     


Arg Asn Lys Gly Pro Gln Leu Gln Lys Glu Ala Val Ser Gly Pro Met 
            420                 425                 430         


Ala Gly Lys Pro Phe Arg Pro Gln Ser Leu Ser Lys Tyr Ser Arg His 
        435                 440                 445             


Tyr Ser Pro Glu Asp Glu Pro Ser Pro Glu Ala Gln Pro Ile Ala Ala 
    450                 455                 460                 


Tyr Lys Ile Val Ser Gln Xaa Asn Lys Gln Ser Ile Ala Gly Ser Val 
465                 470                 475                 480 


Ser Ile Xaa Ser Leu Ser Ser Arg Xaa Xaa Glu Leu Pro Ala Ala Asp 
                485                 490                 495     


Pro Phe Ala Leu Ala Pro Phe Pro Ser Lys Ser Gly Lys Lys Pro 
            500                 505                 510     


<210> 1243
<211> 340
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<400> 1243
Xaa Gln Leu Leu Gln Ala Ala Ala Ala Glu Ala Ser Leu Asn Lys Ser 
1               5                   10                  15      


Lys Ser Ala Xaa Xaa Xaa Pro Ser Gly Ser Pro Arg Xaa Ser Gln Gln 
            20                  25                  30          


Asn Val Tyr Asn Pro Ser Glu Gly Ser Xaa Trp Asn Pro Phe Asp Asp 
        35                  40                  45              


Asp Asn Phe Ser Lys Leu Xaa Ala Glu Glu Leu Leu Asn Lys Asp Phe 
    50                  55                  60                  


Ala Lys Leu Gly Glu Gly Lys His Pro Glu Lys Leu Gly Gly Ser Ala 
65                  70                  75                  80  


Glu Ser Leu Ile Pro Gly Phe Gln Ser Xaa Gln Gly Asp Ala Phe Ala 
                85                  90                  95      


Xaa Xaa Ser Phe Ser Ala Gly Xaa Asp Leu Gln Arg Glu Ser Asn Pro 
            100                 105                 110         


Cys Pro Val Ile Xaa Val Glu His Phe Lys Glu Ser Leu Gly Val Lys 
        115                 120                 125             


Gly Leu Pro Leu Tyr Pro Asp Pro Ser Arg Val Pro Gly Xaa Lys Xaa 
    130                 135                 140                 


Gln Asn Asn Leu Glu Ser Asp Tyr Leu Ala Arg Asp Gly Pro Ser Ser 
145                 150                 155                 160 


Asn Ser Ser Phe His Ser Ser Glu Glu Glu Gly Xaa Asp Leu Glu Gly 
                165                 170                 175     


Asp Met Leu Asp Cys Ser Gly Ser Arg Pro Leu Leu Met Glu Ser Glu 
            180                 185                 190         


Glu Glu Asp Glu Ser Cys Arg Pro Pro Pro Gly Lys Leu Gly Gly Ala 
        195                 200                 205             


Val Pro Phe Ala Pro Pro Glu Val Ser Pro Glu Gln Ala Lys Xaa Val 
    210                 215                 220                 


Gln Gly Gly Arg Lys Asn Gln Phe Gln Ala Phe Xaa Gln Pro Ala Xaa 
225                 230                 235                 240 


Asp Gly Leu Ser Glu Pro Asp Val Phe Ala Ile Ala Pro Phe Arg Ser 
                245                 250                 255     


Ser Arg Val Pro Asn Asp Asp Met Asp Ile Phe Ser Lys Ala Pro Phe 
            260                 265                 270         


Val Ser Lys Ser Ser Met Ala Pro Ser Gln Pro Glu Glu Ser Asp Val 
        275                 280                 285             


Phe Leu Arg Ala Pro Phe Xaa Lys Lys Lys Ser Met Glu Glu Leu Xaa 
    290                 295                 300                 


Val Ile Gln Cys Xaa Ser Gln Glu Leu Pro Ala Gln Xaa Gly Leu Leu 
305                 310                 315                 320 


Ser Gln Xaa Gly Asp Val Pro Leu Pro Ala Gly Arg Glu Arg Ala Val 
                325                 330                 335     


Tyr Xaa Ser Val 
            340 


<210> 1244
<211> 560
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<400> 1244
Met Ala Gly Pro Gln Pro Leu Ala Leu Gln Leu Glu Gln Leu Leu Asn 
1               5                   10                  15      


Pro Arg Pro Ser Glu Ala Asp Pro Glu Ala Asp Pro Glu Glu Ala Xaa 
            20                  25                  30          


Ala Ala Arg Val Ile Asp Arg Phe Asp Glu Gly Glu Asp Gly Glu Gly 
        35                  40                  45              


Asp Phe Leu Val Val Gly Ser Ile Arg Lys Leu Ala Ser Ala Ser Leu 
    50                  55                  60                  


Leu Asp Xaa Asp Lys Arg Tyr Cys Gly Lys Xaa Xaa Ser Arg Lys Ala 
65                  70                  75                  80  


Trp Asn Glu Asp His Trp Glu Gln Xaa Leu Pro Gly Ser Ser Asp Glu 
                85                  90                  95      


Glu Ile Ser Asp Glu Glu Gly Ser Gly Asp Glu Asp Ser Glu Gly Leu 
            100                 105                 110         


Gly Leu Glu Glu Tyr Asp Glu Asp Asp Leu Gly Ala Ala Glu Glu Gln 
        115                 120                 125             


Glu Cys Gly Asp His Arg Glu Ser Lys Lys Ser Arg Ser His Ser Ala 
    130                 135                 140                 


Lys Xaa Pro Gly Phe Ser Val Gln Ser Ile Ser Asp Phe Glu Lys Phe 
145                 150                 155                 160 


Xaa Lys Gly Met Asp Asp Leu Gly Ser Ser Glu Glu Glu Glu Asp Glu 
                165                 170                 175     


Glu Ser Gly Met Glu Glu Gly Asp Asp Ala Glu Asp Ser Gln Gly Glu 
            180                 185                 190         


Ser Glu Glu Asp Arg Ala Gly Asp Arg Asn Ser Glu Asp Asp Gly Val 
        195                 200                 205             


Val Met Xaa Phe Ser Ser Val Lys Val Ser Glu Glu Val Glu Lys Gly 
    210                 215                 220                 


Arg Ala Val Lys Asn Gln Ile Ala Leu Trp Asp Gln Leu Leu Glu Gly 
225                 230                 235                 240 


Arg Ile Lys Leu Gln Lys Ala Leu Leu Xaa Xaa Asn Gln Leu Pro Gln 
                245                 250                 255     


Pro Asp Val Phe Pro Leu Phe Lys Asp Lys Gly Gly Pro Glu Phe Ser 
            260                 265                 270         


Ser Ala Leu Lys Asn Ser His Lys Ala Leu Lys Ala Leu Leu Arg Ser 
        275                 280                 285             


Leu Val Gly Leu Gln Glu Glu Leu Leu Phe Gln Tyr Pro Asp Xaa Arg 
    290                 295                 300                 


Tyr Leu Val Asp Gly Xaa Lys Pro Asn Ala Gly Ser Glu Glu Ile Ser 
305                 310                 315                 320 


Ser Glu Asp Asp Glu Leu Val Glu Glu Lys Lys Gln Gln Arg Arg Arg 
                325                 330                 335     


Val Pro Ala Lys Arg Lys Leu Glu Met Glu Asp Tyr Pro Ser Phe Met 
            340                 345                 350         


Ala Lys Arg Phe Ala Asp Phe Xaa Val Tyr Arg Asn Arg Xaa Leu Gln 
        355                 360                 365             


Lys Trp His Asp Lys Xaa Lys Leu Ala Ser Gly Lys Leu Gly Lys Gly 
    370                 375                 380                 


Phe Gly Ala Phe Glu Arg Ser Ile Leu Xaa Gln Ile Asp His Ile Leu 
385                 390                 395                 400 


Met Asp Lys Glu Arg Leu Leu Arg Arg Xaa Gln Xaa Lys Arg Ser Val 
                405                 410                 415     


Tyr Arg Val Leu Gly Lys Pro Glu Pro Ala Ala Gln Pro Val Pro Glu 
            420                 425                 430         


Ser Leu Pro Gly Glu Pro Glu Ile Leu Pro Gln Ala Pro Ala Asn Ala 
        435                 440                 445             


His Leu Lys Asp Leu Asp Glu Glu Ile Phe Asp Asp Asp Asp Phe Tyr 
    450                 455                 460                 


His Gln Leu Leu Arg Glu Leu Ile Glu Arg Lys Xaa Ser Ser Leu Asp 
465                 470                 475                 480 


Pro Asn Asp Gln Val Ala Met Gly Arg Gln Trp Leu Ala Ile Gln Lys 
                485                 490                 495     


Leu Arg Ser Lys Ile His Lys Lys Val Asp Arg Lys Ala Ser Lys Gly 
            500                 505                 510         


Arg Lys Leu Arg Phe His Val Leu Ser Lys Leu Leu Ser Phe Met Ala 
        515                 520                 525             


Pro Ile Asp His Xaa Xaa Met Asn Asp Asp Ala Arg Xaa Glu Leu Tyr 
    530                 535                 540                 


Arg Ser Leu Phe Gly Gln Leu His Pro Pro Asp Glu Gly His Gly Asp 
545                 550                 555                 560 


<210> 1245
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<400> 1245
Met Ala Gly Pro Gln Pro Leu Ala Leu Gln Leu Glu Gln Leu Leu Asn 
1               5                   10                  15      


Pro Arg Pro Ser Glu Ala Asp Pro Glu Ala Asp Pro Glu Glu Ala Xaa 
            20                  25                  30          


Ala Ala Arg Val Ile Asp Arg Phe Asp Glu Gly Glu Asp Gly Glu Gly 
        35                  40                  45              


Ser Asn Tyr Lys Lys Leu Cys 
    50                  55  


<210> 1246
<211> 154
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<400> 1246
Arg Asn Arg Xaa Leu Gln Lys Trp His Asp Lys Xaa Lys Leu Ala Ser 
1               5                   10                  15      


Gly Lys Leu Gly Lys Gly Phe Gly Ala Phe Glu Arg Ser Ile Leu Xaa 
            20                  25                  30          


Gln Ile Asp His Ile Leu Met Asp Lys Glu Arg Leu Leu Arg Arg Xaa 
        35                  40                  45              


Gln Xaa Lys Arg Ser Val Tyr Arg Val Leu Gly Lys Pro Glu Pro Ala 
    50                  55                  60                  


Ala Gln Pro Val Pro Glu Ser Leu Pro Gly Glu Pro Glu Ile Leu Pro 
65                  70                  75                  80  


Gln Ala Pro Ala Asn Ala His Leu Lys Asp Leu Asp Glu Glu Ile Phe 
                85                  90                  95      


Asp Asp Asp Asp Phe Tyr His Gln Leu Leu Arg Glu Leu Ile Glu Arg 
            100                 105                 110         


Lys Xaa Ser Ser Leu Asp Pro Asn Asp Gln Val Ala Met Gly Arg Gln 
        115                 120                 125             


Trp Leu Ala Ile Gln Lys Leu Arg Ser Lys Ile His Lys Lys Val Asp 
    130                 135                 140                 


Arg Lys Ala Ser Lys Gly Arg Lys Leu Arg 
145                 150                 


<210> 1247
<211> 98
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<400> 1247
Xaa Ile Leu Pro Gln Ala Pro Ala Asn Ala His Leu Lys Asp Leu Asp 
1               5                   10                  15      


Glu Glu Ile Phe Asp Asp Asp Asp Phe Tyr His Gln Leu Leu Arg Glu 
            20                  25                  30          


Leu Ile Glu Arg Lys Xaa Ser Ser Leu Asp Pro Asn Asp Gln Val Ala 
        35                  40                  45              


Met Gly Arg Gln Trp Leu Ala Ile Gln Lys Leu Arg Ser Lys Ile His 
    50                  55                  60                  


Lys Lys Val Asp Arg Lys Ala Ser Lys Gly Arg Lys Leu Arg Xaa Glu 
65                  70                  75                  80  


Leu Tyr Arg Ser Leu Phe Gly Gln Leu His Pro Pro Asp Glu Gly His 
                85                  90                  95      


Gly Asp 
        


<210> 1248
<211> 363
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<400> 1248
Met Ala Cys Trp Pro Gln Leu Arg Leu Leu Leu Trp Lys Asn Leu Xaa 
1               5                   10                  15      


Phe Arg Arg Arg Gln Xaa Cys Gln Leu Leu Leu Glu Val Ala Trp Pro 
            20                  25                  30          


Leu Phe Ile Phe Leu Ile Leu Ile Ser Val Arg Leu Ser Tyr Pro Pro 
        35                  40                  45              


Tyr Glu Gln His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Xaa Leu Pro Trp Val Gln Gly Ile Ile Cys Asn Ala Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Arg Tyr Pro Xaa Pro Gly Glu Ala Pro Gly Val Val Gly Asn 
                85                  90                  95      


Phe Asn Lys Ser Ile Val Ala Arg Leu Phe Ser Asp Ala Arg Arg Leu 
            100                 105                 110         


Leu Leu Tyr Ser Gln Lys Asp Xaa Ser Met Lys Asp Met Arg Lys Val 
        115                 120                 125             


Leu Arg Xaa Leu Gln Gln Ile Lys Lys Ser Ser Ser Asn Leu Lys Leu 
    130                 135                 140                 


Gln Asp Phe Leu Val Asp Asn Glu Xaa Phe Ser Gly Phe Leu Tyr His 
145                 150                 155                 160 


Asn Leu Ser Leu Pro Lys Ser Xaa Val Asp Lys Met Leu Arg Ala Asp 
                165                 170                 175     


Val Ile Leu His Lys Val Phe Leu Gln Gly Tyr Gln Leu His Leu Xaa 
            180                 185                 190         


Ser Leu Cys Asn Gly Ser Lys Ser Glu Glu Met Ile Gln Leu Gly Asp 
        195                 200                 205             


Gln Glu Val Ser Glu Leu Cys Gly Leu Pro Arg Glu Lys Leu Ala Ala 
    210                 215                 220                 


Ala Glu Arg Val Leu Arg Ser Asn Met Asp Ile Leu Lys Pro Ile Leu 
225                 230                 235                 240 


Met Asp Val Xaa Cys Asp Asp Ile Ala His Gly Gln Leu Xaa Val Pro 
                245                 250                 255     


Arg Ser Ala Ala Val Ala Ala Xaa Gly Asp Ala Lys Pro Asn Met Met 
            260                 265                 270         


Gly Arg Glu Xaa Leu Leu Ser Ile Cys Ala Ser Val Pro Lys Val Glu 
        275                 280                 285             


Phe His Glu Arg His Ile Leu Lys His Phe Ser Phe Cys Val Cys Val 
    290                 295                 300                 


Ser Val Ser Leu Phe Pro Ala Lys Gly Ile Val Ser Phe Ser Trp Ala 
305                 310                 315                 320 


Ser Phe Arg Ile Trp Val Leu Trp Lys Ala Val Phe Trp Gln His Gly 
                325                 330                 335     


Glu Ser Met Ala Val Trp Glu Gly Gln Leu Gly Leu Gly Leu Asn Ile 
            340                 345                 350         


Ala Phe Glu Tyr Phe Xaa Ser Ile Asp Val Gly 
        355                 360             


<210> 1249
<211> 2261
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1083)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1325)..(1325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1399)..(1399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1409)..(1409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1416)..(1416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1437)..(1438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1444)..(1444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1493)..(1493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1501)..(1501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1512)..(1512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1630)..(1630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1639)..(1639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1650)..(1651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1715)..(1715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1733)..(1733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1750)..(1750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1765)..(1765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1771)..(1771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1785)..(1785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1792)..(1792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1867)..(1867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1918)..(1918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1955)..(1955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1960)..(1960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1963)..(1964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1966)..(1966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1998)..(1998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2002)..(2002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2055)..(2055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2072)..(2073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2100)..(2100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2112)..(2112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2140)..(2140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2211)..(2212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2240)..(2240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2248)..(2248)
<223> Selenocysteine

<400> 1249
Met Ala Cys Trp Pro Gln Leu Arg Leu Leu Leu Trp Lys Asn Leu Xaa 
1               5                   10                  15      


Phe Arg Arg Arg Gln Xaa Cys Gln Leu Leu Leu Glu Val Ala Trp Pro 
            20                  25                  30          


Leu Phe Ile Phe Leu Ile Leu Ile Ser Val Arg Leu Ser Tyr Pro Pro 
        35                  40                  45              


Tyr Glu Gln His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Xaa Leu Pro Trp Val Gln Gly Ile Ile Cys Asn Ala Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Arg Tyr Pro Xaa Pro Gly Glu Ala Pro Gly Val Val Gly Asn 
                85                  90                  95      


Phe Asn Lys Ser Ile Val Ala Arg Leu Phe Ser Asp Ala Arg Arg Leu 
            100                 105                 110         


Leu Leu Tyr Ser Gln Lys Asp Xaa Ser Met Lys Asp Met Arg Lys Val 
        115                 120                 125             


Leu Arg Xaa Leu Gln Gln Ile Lys Lys Ser Ser Ser Asn Leu Lys Leu 
    130                 135                 140                 


Gln Asp Phe Leu Val Asp Asn Glu Xaa Phe Ser Gly Phe Leu Tyr His 
145                 150                 155                 160 


Asn Leu Ser Leu Pro Lys Ser Xaa Val Asp Lys Met Leu Arg Ala Asp 
                165                 170                 175     


Val Ile Leu His Lys Val Phe Leu Gln Gly Tyr Gln Leu His Leu Xaa 
            180                 185                 190         


Ser Leu Cys Asn Gly Ser Lys Ser Glu Glu Met Ile Gln Leu Gly Asp 
        195                 200                 205             


Gln Glu Val Ser Glu Leu Cys Gly Leu Pro Arg Glu Lys Leu Ala Ala 
    210                 215                 220                 


Ala Glu Arg Val Leu Arg Ser Asn Met Asp Ile Leu Lys Pro Ile Leu 
225                 230                 235                 240 


Arg Xaa Leu Asn Ser Xaa Ser Pro Phe Pro Ser Lys Glu Leu Ala Glu 
                245                 250                 255     


Ala Xaa Lys Xaa Leu Leu His Ser Leu Gly Xaa Leu Ala Gln Glu Leu 
            260                 265                 270         


Phe Ser Met Arg Ser Trp Ser Asp Met Arg Gln Glu Val Met Phe Leu 
        275                 280                 285             


Xaa Asn Val Asn Ser Ser Ser Ser Ser Xaa Gln Ile Tyr Gln Ala Val 
    290                 295                 300                 


Ser Arg Ile Val Cys Gly His Pro Glu Gly Gly Gly Leu Lys Ile Lys 
305                 310                 315                 320 


Ser Leu Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Leu Phe Gly Gly 
                325                 330                 335     


Asn Gly Xaa Glu Glu Asp Ala Glu Xaa Phe Tyr Asp Asn Ser Xaa Xaa 
            340                 345                 350         


Pro Tyr Cys Asn Asp Leu Met Lys Asn Leu Glu Ser Ser Pro Leu Ser 
        355                 360                 365             


Arg Ile Ile Trp Lys Ala Leu Lys Pro Leu Leu Val Gly Lys Ile Leu 
    370                 375                 380                 


Tyr Xaa Pro Asp Xaa Pro Ala Xaa Arg Gln Val Met Ala Glu Val Asn 
385                 390                 395                 400 


Lys Xaa Phe Gln Glu Leu Ala Val Phe His Asp Leu Glu Gly Met Trp 
                405                 410                 415     


Glu Glu Leu Ser Pro Lys Ile Trp Xaa Phe Met Glu Asn Ser Gln Glu 
            420                 425                 430         


Met Asp Leu Val Arg Met Leu Leu Asp Ser Arg Asp Asn Asp His Phe 
        435                 440                 445             


Trp Glu Gln Gln Leu Asp Gly Leu Asp Trp Xaa Ala Gln Asp Ile Val 
    450                 455                 460                 


Ala Phe Leu Ala Lys His Pro Glu Asp Val Gln Ser Ser Asn Gly Ser 
465                 470                 475                 480 


Val Tyr Xaa Trp Arg Glu Ala Phe Asn Glu Xaa Asn Gln Ala Ile Arg 
                485                 490                 495     


Xaa Ile Ser Arg Phe Met Glu Cys Val Asn Leu Asn Lys Leu Glu Pro 
            500                 505                 510         


Ile Ala Xaa Glu Val Trp Leu Ile Asn Lys Ser Met Glu Leu Leu Asp 
        515                 520                 525             


Glu Arg Lys Phe Trp Ala Gly Ile Val Phe Xaa Gly Ile Xaa Pro Gly 
    530                 535                 540                 


Ser Ile Glu Leu Pro His His Val Lys Tyr Lys Ile Arg Met Asp Ile 
545                 550                 555                 560 


Asp Asn Val Glu Arg Xaa Asn Lys Ile Lys Asp Gly Tyr Trp Asp Pro 
                565                 570                 575     


Gly Pro Arg Ala Asp Pro Phe Glu Asp Met Arg Tyr Val Trp Gly Gly 
            580                 585                 590         


Phe Ala Tyr Leu Gln Asp Val Val Glu Gln Ala Ile Ile Arg Val Leu 
        595                 600                 605             


Xaa Gly Xaa Glu Lys Lys Xaa Gly Val Tyr Met Gln Gln Met Pro Tyr 
    610                 615                 620                 


Pro Cys Tyr Val Asp Asp Ile Phe Leu Arg Val Met Ser Arg Ser Met 
625                 630                 635                 640 


Pro Leu Phe Met Xaa Leu Ala Trp Ile Tyr Ser Val Ala Val Ile Ile 
                645                 650                 655     


Lys Gly Ile Val Tyr Glu Lys Glu Ala Arg Leu Lys Glu Xaa Met Arg 
            660                 665                 670         


Ile Met Gly Leu Asp Asn Ser Ile Leu Trp Phe Ser Trp Phe Ile Ser 
        675                 680                 685             


Ser Leu Ile Pro Leu Leu Val Ser Ala Gly Leu Leu Val Val Ile Leu 
    690                 695                 700                 


Lys Leu Gly Asn Leu Leu Pro Tyr Ser Asp Pro Ser Val Val Phe Val 
705                 710                 715                 720 


Phe Leu Ser Val Phe Ala Val Val Xaa Ile Leu Gln Cys Phe Leu Ile 
                725                 730                 735     


Ser Xaa Leu Phe Ser Arg Ala Asn Leu Ala Ala Ala Cys Gly Gly Ile 
            740                 745                 750         


Ile Tyr Phe Xaa Leu Tyr Leu Pro Tyr Val Leu Cys Val Ala Trp Gln 
        755                 760                 765             


Asp Tyr Val Gly Phe Xaa Leu Lys Ile Phe Ala Ser Leu Leu Ser Pro 
    770                 775                 780                 


Val Ala Phe Gly Phe Gly Cys Glu Tyr Phe Ala Leu Phe Glu Glu Gln 
785                 790                 795                 800 


Gly Ile Gly Val Gln Trp Asp Asn Leu Phe Glu Ser Pro Val Glu Glu 
                805                 810                 815     


Asp Gly Phe Asn Leu Xaa Xaa Ser Val Ser Met Met Leu Phe Asp Xaa 
            820                 825                 830         


Phe Leu Tyr Gly Val Met Xaa Trp Tyr Ile Glu Ala Val Phe Pro Gly 
        835                 840                 845             


Gln Tyr Gly Ile Pro Arg Pro Trp Tyr Phe Pro Cys Xaa Lys Ser Tyr 
    850                 855                 860                 


Trp Phe Gly Glu Glu Ser Asp Glu Lys Ser His Pro Gly Ser Asn Gln 
865                 870                 875                 880 


Lys Arg Ile Ser Glu Ile Cys Met Glu Glu Glu Pro Xaa His Leu Lys 
                885                 890                 895     


Leu Gly Val Ser Ile Gln Asn Leu Val Lys Val Tyr Arg Asp Gly Met 
            900                 905                 910         


Lys Val Ala Val Asp Gly Leu Ala Leu Asn Phe Tyr Glu Gly Gln Ile 
        915                 920                 925             


Xaa Ser Phe Leu Gly His Asn Gly Ala Gly Lys Xaa Xaa Xaa Met Ser 
    930                 935                 940                 


Ile Leu Xaa Gly Leu Phe Pro Pro Xaa Ser Gly Xaa Ala Tyr Ile Leu 
945                 950                 955                 960 


Gly Lys Asp Ile Arg Ser Glu Met Ser Xaa Ile Arg Gln Asn Leu Gly 
                965                 970                 975     


Val Cys Pro Gln His Asn Val Leu Phe Asp Met Leu Xaa Val Glu Glu 
            980                 985                 990         


His Ile Trp Phe Tyr Ala Arg Leu  Lys Gly Leu Ser Glu  Lys His Val 
        995                 1000                 1005             


Lys Ala  Glu Met Glu Gln Met  Ala Leu Asp Val Gly  Leu Pro Ser 
    1010                 1015                 1020             


Ser Lys  Leu Lys Ser Lys Xaa  Ser Gln Leu Ser Gly  Gly Met Gln 
    1025                 1030                 1035             


Arg Lys  Leu Ser Val Ala Leu  Ala Phe Val Gly Gly  Ser Lys Val 
    1040                 1045                 1050             


Val Ile  Leu Asp Glu Pro Xaa  Ala Gly Val Asp Pro  Tyr Ser Arg 
    1055                 1060                 1065             


Arg Gly  Ile Trp Glu Leu Leu  Leu Lys Tyr Arg Gln  Gly Arg Xaa 
    1070                 1075                 1080             


Ile Ile  Leu Ser Xaa His His  Met Asp Glu Ala Asp  Val Leu Gly 
    1085                 1090                 1095             


Asp Arg  Ile Ala Ile Ile Ser  His Gly Lys Leu Cys  Cys Val Gly 
    1100                 1105                 1110             


Ser Ser  Leu Phe Leu Lys Asn  Gln Leu Gly Xaa Gly  Tyr Tyr Leu 
    1115                 1120                 1125             


Xaa Leu  Val Lys Lys Asp Val  Glu Ser Ser Leu Ser  Ser Cys Arg 
    1130                 1135                 1140             


Asn Ser  Ser Ser Xaa Val Ser  Tyr Leu Lys Lys Glu  Asp Ser Val 
    1145                 1150                 1155             


Ser Gln  Ser Ser Ser Asp Ala  Gly Leu Gly Ser Asp  His Glu Ser 
    1160                 1165                 1170             


Asp Xaa  Leu Xaa Ile Asp Val  Ser Ala Ile Ser Asn  Leu Ile Arg 
    1175                 1180                 1185             


Lys His  Val Ser Glu Ala Arg  Leu Val Glu Asp Ile  Gly His Glu 
    1190                 1195                 1200             


Leu Xaa  Tyr Val Leu Pro Tyr  Glu Ala Ala Lys Glu  Gly Ala Phe 
    1205                 1210                 1215             


Val Glu  Leu Phe His Glu Ile  Asp Asp Arg Leu Ser  Asp Leu Gly 
    1220                 1225                 1230             


Ile Ser  Ser Tyr Gly Ile Ser  Glu Xaa Xaa Leu Glu  Glu Ile Phe 
    1235                 1240                 1245             


Leu Lys  Val Ala Glu Glu Ser  Gly Val Asp Ala Glu  Xaa Ser Asp 
    1250                 1255                 1260             


Gly Xaa  Leu Pro Ala Arg Arg  Asn Arg Arg Ala Phe  Gly Asp Lys 
    1265                 1270                 1275             


Gln Ser  Cys Leu Arg Pro Phe  Xaa Glu Asp Asp Ala  Ala Asp Pro 
    1280                 1285                 1290             


Asn Asp  Ser Asp Ile Asp Pro  Glu Ser Arg Glu Xaa  Asp Leu Leu 
    1295                 1300                 1305             


Ser Gly  Met Asp Gly Lys Gly  Ser Tyr Gln Val Lys  Gly Trp Lys 
    1310                 1315                 1320             


Leu Xaa  Gln Gln Gln Phe Val  Ala Leu Leu Trp Lys  Arg Leu Leu 
    1325                 1330                 1335             


Ile Ala  Arg Arg Ser Arg Lys  Gly Phe Phe Ala Gln  Ile Val Leu 
    1340                 1345                 1350             


Pro Ala  Val Phe Val Cys Ile  Ala Leu Val Phe Ser  Leu Ile Val 
    1355                 1360                 1365             


Pro Pro  Phe Gly Lys Tyr Pro  Ser Leu Glu Leu Gln  Pro Trp Met 
    1370                 1375                 1380             


Tyr Asn  Glu Gln Tyr Xaa Phe  Val Ser Asn Asp Ala  Pro Glu Asp 
    1385                 1390                 1395             


Xaa Gly  Xaa Leu Glu Leu Leu  Asn Ala Leu Xaa Lys  Asp Pro Gly 
    1400                 1405                 1410             


Phe Gly  Xaa Arg Cys Met Glu  Gly Asn Pro Ile Pro  Asp Xaa Pro 
    1415                 1420                 1425             


Cys Gln  Ala Gly Glu Glu Glu  Trp Xaa Xaa Ala Pro  Val Pro Gln 
    1430                 1435                 1440             


Xaa Ile  Met Asp Leu Phe Gln  Asn Gly Asn Trp Xaa  Met Gln Asn 
    1445                 1450                 1455             


Pro Ser  Pro Ala Cys Gln Cys  Ser Ser Asp Lys Ile  Lys Lys Met 
    1460                 1465                 1470             


Leu Pro  Val Cys Pro Pro Gly  Ala Gly Gly Leu Pro  Pro Pro Gln 
    1475                 1480                 1485             


Arg Lys  Gln Asn Xaa Ala Asp  Ile Leu Gln Asp Leu  Xaa Gly Arg 
    1490                 1495                 1500             


Asn Ile  Ser Asp Tyr Leu Val  Lys Xaa Tyr Val Gln  Ile Ile Ala 
    1505                 1510                 1515             


Lys Ser  Leu Lys Asn Lys Ile  Trp Val Asn Glu Phe  Arg Tyr Gly 
    1520                 1525                 1530             


Gly Phe  Ser Leu Gly Val Ser  Asn Xaa Gln Ala Leu  Pro Pro Ser 
    1535                 1540                 1545             


Gln Glu  Val Asn Asp Ala Ile  Lys Gln Met Lys Lys  His Leu Lys 
    1550                 1555                 1560             


Leu Ala  Lys Asp Ser Ser Ala  Asp Arg Phe Leu Asn  Ser Leu Gly 
    1565                 1570                 1575             


Arg Phe  Met Xaa Gly Leu Asp  Xaa Lys Asn Asn Val  Lys Val Trp 
    1580                 1585                 1590             


Phe Asn  Asn Lys Gly Trp His  Ala Ile Ser Ser Phe  Leu Asn Val 
    1595                 1600                 1605             


Ile Asn  Asn Ala Ile Leu Arg  Ala Asn Leu Gln Lys  Gly Glu Asn 
    1610                 1615                 1620             


Pro Ser  His Tyr Gly Ile Xaa  Ala Phe Asn His Pro  Leu Asn Leu 
    1625                 1630                 1635             


Xaa Lys  Gln Gln Leu Ser Glu  Val Ala Leu Met Xaa  Xaa Ser Val 
    1640                 1645                 1650             


Asp Val  Leu Val Ser Ile Cys  Val Ile Phe Ala Met  Ser Phe Val 
    1655                 1660                 1665             


Pro Ala  Ser Phe Val Val Phe  Leu Ile Gln Glu Arg  Val Ser Lys 
    1670                 1675                 1680             


Ala Lys  His Leu Gln Phe Ile  Ser Gly Val Lys Pro  Val Ile Tyr 
    1685                 1690                 1695             


Trp Leu  Ser Asn Phe Val Trp  Asp Met Cys Asn Tyr  Val Val Pro 
    1700                 1705                 1710             


Ala Xaa  Leu Val Ile Ile Ile  Phe Ile Cys Phe Gln  Gln Lys Ser 
    1715                 1720                 1725             


Tyr Val  Ser Ser Xaa Asn Leu  Pro Val Leu Ala Leu  Leu Leu Leu 
    1730                 1735                 1740             


Leu Tyr  Gly Trp Ser Ile Xaa  Pro Leu Met Tyr Pro  Ala Ser Phe 
    1745                 1750                 1755             


Val Phe  Lys Ile Pro Ser Xaa  Ala Tyr Val Val Leu  Xaa Ser Val 
    1760                 1765                 1770             


Asn Leu  Phe Ile Gly Ile Asn  Gly Ser Val Ala Xaa  Phe Val Leu 
    1775                 1780                 1785             


Glu Leu  Phe Xaa Asp Asn Lys  Leu Asn Asn Ile Asn  Asp Ile Leu 
    1790                 1795                 1800             


Lys Ser  Val Phe Leu Ile Phe  Pro His Phe Cys Leu  Gly Arg Gly 
    1805                 1810                 1815             


Leu Ile  Asp Met Val Lys Asn  Gln Ala Met Ala Asp  Ala Leu Glu 
    1820                 1825                 1830             


Arg Phe  Gly Glu Asn Arg Phe  Val Ser Pro Leu Ser  Trp Asp Leu 
    1835                 1840                 1845             


Val Gly  Arg Asn Leu Phe Ala  Met Ala Val Glu Gly  Val Val Phe 
    1850                 1855                 1860             


Phe Leu  Ile Xaa Val Leu Ile  Gln Tyr Arg Phe Phe  Ile Arg Pro 
    1865                 1870                 1875             


Arg Pro  Val Asn Ala Lys Leu  Ser Pro Leu Asn Asp  Glu Asp Glu 
    1880                 1885                 1890             


Asp Val  Arg Arg Glu Arg Gln  Arg Ile Leu Asp Gly  Gly Gly Gln 
    1895                 1900                 1905             


Asn Asp  Ile Leu Glu Ile Lys  Glu Leu Xaa Lys Ile  Tyr Arg Arg 
    1910                 1915                 1920             


Lys Arg  Lys Pro Ala Val Asp  Arg Ile Cys Val Gly  Ile Pro Pro 
    1925                 1930                 1935             


Gly Glu  Cys Phe Gly Leu Leu  Gly Val Asn Gly Ala  Gly Lys Ser 
    1940                 1945                 1950             


Ser Xaa  Phe Lys Met Leu Xaa  Gly Asp Xaa Xaa Val  Xaa Arg Gly 
    1955                 1960                 1965             


Asp Ala  Phe Leu Asn Lys Asn  Ser Ile Leu Ser Asn  Ile His Glu 
    1970                 1975                 1980             


Val His  Gln Asn Met Gly Tyr  Cys Pro Gln Phe Asp  Ala Ile Xaa 
    1985                 1990                 1995             


Glu Leu  Leu Xaa Gly Arg Glu  His Val Glu Phe Phe  Ala Leu Leu 
    2000                 2005                 2010             


Arg Gly  Val Pro Glu Lys Glu  Val Gly Lys Val Gly  Glu Trp Ala 
    2015                 2020                 2025             


Ile Arg  Lys Leu Gly Leu Val  Lys Tyr Gly Glu Lys  Tyr Ala Gly 
    2030                 2035                 2040             


Asn Tyr  Ser Gly Gly Asn Lys  Arg Lys Leu Ser Xaa  Ala Met Ala 
    2045                 2050                 2055             


Leu Ile  Gly Gly Pro Pro Val  Val Phe Leu Asp Glu  Pro Xaa Xaa 
    2060                 2065                 2070             


Gly Met  Asp Pro Lys Ala Arg  Arg Phe Leu Trp Asn  Cys Ala Leu 
    2075                 2080                 2085             


Ser Val  Val Lys Glu Gly Arg  Ser Val Val Leu Xaa  Ser His Ser 
    2090                 2095                 2100             


Met Glu  Glu Cys Glu Ala Leu  Cys Xaa Arg Met Ala  Ile Met Val 
    2105                 2110                 2115             


Asn Gly  Arg Phe Arg Cys Leu  Gly Ser Val Gln His  Leu Lys Asn 
    2120                 2125                 2130             


Arg Phe  Gly Asp Gly Tyr Xaa  Ile Val Val Arg Ile  Ala Gly Ser 
    2135                 2140                 2145             


Asn Pro  Asp Leu Lys Pro Val  Gln Asp Phe Phe Gly  Leu Ala Phe 
    2150                 2155                 2160             


Pro Gly  Ser Val Leu Lys Glu  Lys His Arg Asn Met  Leu Gln Tyr 
    2165                 2170                 2175             


Gln Leu  Pro Ser Ser Leu Ser  Ser Leu Ala Arg Ile  Phe Ser Ile 
    2180                 2185                 2190             


Leu Ser  Gln Ser Lys Lys Arg  Leu His Ile Glu Asp  Tyr Ser Val 
    2195                 2200                 2205             


Ser Gln  Xaa Xaa Leu Asp Gln  Val Phe Val Asn Phe  Ala Lys Asp 
    2210                 2215                 2220             


Gln Ser  Asp Asp Asp His Leu  Lys Asp Leu Ser Leu  His Lys Asn 
    2225                 2230                 2235             


Gln Xaa  Val Val Asp Val Ala  Val Leu Xaa Ser Phe  Leu Gln Asp 
    2240                 2245                 2250             


Glu Lys  Val Lys Glu Ser Tyr  Val 
    2255                 2260     


<210> 1250
<211> 123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<400> 1250
Met Pro Ser Ala Gly Xaa Leu Pro Trp Val Gln Gly Ile Ile Cys Asn 
1               5                   10                  15      


Ala Asn Asn Pro Cys Phe Arg Tyr Pro Xaa Pro Gly Glu Ala Pro Gly 
            20                  25                  30          


Val Val Gly Asn Phe Asn Lys Ser Ile Val Ala Arg Leu Phe Ser Asp 
        35                  40                  45              


Ala Arg Arg Leu Leu Leu Tyr Ser Gln Lys Asp Xaa Ser Met Lys Asp 
    50                  55                  60                  


Met Arg Lys Val Leu Arg Xaa Leu Gln Gln Ile Lys Lys Ser Ser Ser 
65                  70                  75                  80  


Asn Leu Lys Leu Gln Asp Phe Leu Val Asp Asn Glu Xaa Phe Ser Gly 
                85                  90                  95      


Phe Leu Tyr His Asn Leu Ser Leu Pro Lys Ser Xaa Val Asp Lys Met 
            100                 105                 110         


Leu Arg Ala Asp Val Ile Leu His Lys Val Ser 
        115                 120             


<210> 1251
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 1251
Met Ala Phe Trp Xaa Gln Leu Met Leu Leu Leu Trp Lys Asn Phe Met 
1               5                   10                  15      


Tyr Arg Arg Arg Gln Pro Leu Leu Val Glu Leu Leu Trp Pro Leu Phe 
            20                  25                  30          


Leu Phe Phe Ile Leu Val Ala Val Arg His Ser His Pro Pro Leu Glu 
        35                  40                  45              


His His Glu Cys His Phe Pro Asn Lys Pro Leu Pro Ser Ala Gly Xaa 
    50                  55                  60                  


Val Pro Trp Leu Gln Gly Leu Ile Cys Asn Val Asn Asn Xaa Cys Phe 
65                  70                  75                  80  


Pro Gln Leu Xaa Pro Gly Glu Glu Pro Gly Arg Leu Ser Asn Phe Asn 
                85                  90                  95      


Asp Ser Leu Val Ser Arg Leu Leu Ala Asp Ala Arg Xaa Val Leu Gly 
            100                 105                 110         


Gly Ala Ser Ala His Arg Xaa Leu Ala Gly Leu Gly Lys Leu Ile Ala 
        115                 120                 125             


Xaa Leu Arg Ala Ala Arg Ser Xaa 
    130                 135     


<210> 1252
<211> 36
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<400> 1252
Met Ala Phe Trp Xaa Gln Leu Met Leu Leu Leu Trp Lys Asn Phe Met 
1               5                   10                  15      


Tyr Arg Arg Arg Gln Pro Val Gln Leu Leu Val Glu Leu Leu Trp Pro 
            20                  25                  30          


Leu Phe Leu Phe 
        35      


<210> 1253
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<400> 1253
Met Ala Phe Trp Xaa Gln Leu Met Leu Leu Leu Trp Lys Asn Phe Met 
1               5                   10                  15      


Tyr Arg Arg Arg Gln Pro Val Gln Leu Leu Val Glu Leu Leu Trp Pro 
            20                  25                  30          


Leu Phe Leu Phe Phe Ile Leu Val Ala Val Arg His Ser His Pro Pro 
        35                  40                  45              


Leu Glu His His Glu Cys His Phe Pro Asn Lys Pro Leu Pro Ser Ala 
    50                  55                  60                  


Gly Xaa Val Pro Trp Leu Gln Gly Leu Ile Cys Asn Val Asn Asn Xaa 
65                  70                  75                  80  


Cys Phe Pro Gln Leu Xaa Pro Gly Glu Glu Pro Gly Arg Leu Ser Asn 
                85                  90                  95      


Phe Asn Asp Ser Leu Val Ser Arg Leu Leu Ala Asp Ala Arg Xaa Val 
            100                 105                 110         


Leu Gly Gly Ala Ser Ala His Arg Xaa Leu Ala Gly Leu Gly Lys Leu 
        115                 120                 125             


Ile Ala Xaa Leu Arg Ala Ala Arg Ser Xaa Ala Gln Pro Gln Pro Xaa 
    130                 135                 140                 


Lys Gln Ser Pro Leu Glu Pro Pro Met Leu Asp Val Ala Glu Leu Leu 
145                 150                 155                 160 


Xaa Ser Leu Leu 
                


<210> 1254
<211> 2146
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1106)..(1106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1383)..(1383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1394)..(1394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1405)..(1405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1459)..(1459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1511)..(1512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1520)..(1520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1554)..(1554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1563)..(1563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1577)..(1577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1631)..(1631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1652)..(1652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1666)..(1666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1748)..(1748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1788)..(1788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1799)..(1799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1834)..(1834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1836)..(1836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1841)..(1841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1844)..(1844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1883)..(1883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1905)..(1905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1925)..(1925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1936)..(1936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1953)..(1954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1981)..(1981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2021)..(2021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2023)..(2023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2091)..(2091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2110)..(2110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2141)..(2141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2144)..(2144)
<223> Selenocysteine

<400> 1254
Met Ala Phe Trp Xaa Gln Leu Met Leu Leu Leu Trp Lys Asn Phe Met 
1               5                   10                  15      


Tyr Arg Arg Arg Gln Pro Val Gln Leu Leu Val Glu Leu Leu Trp Pro 
            20                  25                  30          


Leu Phe Leu Phe Phe Ile Leu Val Ala Val Arg His Ser His Pro Pro 
        35                  40                  45              


Leu Glu His His Glu Cys His Phe Pro Asn Lys Pro Leu Pro Ser Ala 
    50                  55                  60                  


Gly Xaa Val Pro Trp Leu Gln Gly Leu Ile Cys Asn Val Asn Asn Xaa 
65                  70                  75                  80  


Cys Phe Pro Gln Leu Xaa Pro Gly Glu Glu Pro Gly Arg Leu Ser Asn 
                85                  90                  95      


Phe Asn Asp Ser Leu Val Ser Arg Leu Leu Ala Asp Ala Arg Xaa Val 
            100                 105                 110         


Leu Gly Gly Ala Ser Ala His Arg Xaa Leu Ala Gly Leu Gly Lys Leu 
        115                 120                 125             


Ile Ala Xaa Leu Arg Ala Ala Arg Ser Xaa Ala Gln Pro Gln Pro Xaa 
    130                 135                 140                 


Lys Gln Ser Pro Leu Glu Pro Pro Met Leu Asp Val Ala Glu Leu Leu 
145                 150                 155                 160 


Xaa Ser Leu Leu Arg Xaa Glu Ser Leu Gly Leu Ala Leu Gly Gln Ala 
                165                 170                 175     


Gln Glu Pro Leu His Ser Leu Leu Glu Ala Ala Glu Asp Leu Ala Gln 
            180                 185                 190         


Glu Leu Leu Ala Leu Arg Ser Leu Val Glu Leu Arg Ala Leu Leu Gln 
        195                 200                 205             


Arg Pro Arg Gly Xaa Ser Gly Pro Leu Glu Leu Leu Ser Glu Ala Leu 
    210                 215                 220                 


Cys Ser Val Arg Gly Pro Ser Ser Xaa Val Gly Pro Ser Leu Asn Trp 
225                 230                 235                 240 


Tyr Glu Ala Ser Asp Leu Met Glu Leu Val Gly Gln Glu Pro Glu Ser 
                245                 250                 255     


Ala Leu Pro Asp Ser Ser Leu Ser Pro Ala Cys Ser Glu Leu Ile Gly 
            260                 265                 270         


Ala Leu Asp Ser His Pro Leu Ser Arg Leu Leu Trp Arg Arg Leu Lys 
        275                 280                 285             


Pro Leu Ile Leu Gly Lys Leu Leu Phe Ala Pro Asp Xaa Pro Phe Xaa 
    290                 295                 300                 


Arg Lys Leu Met Ala Gln Val Asn Arg Xaa Phe Glu Glu Leu Xaa Leu 
305                 310                 315                 320 


Leu Arg Asp Val Arg Glu Val Trp Glu Met Leu Gly Pro Arg Ile Phe 
                325                 330                 335     


Xaa Phe Met Asn Asp Ser Ser Asn Val Ala Met Leu Gln Arg Leu Leu 
            340                 345                 350         


Gln Met Gln Asp Glu Gly Arg Arg Gln Pro Arg Pro Gly Gly Arg Asp 
        355                 360                 365             


His Met Glu Ala Leu Arg Ser Phe Leu Asp Pro Gly Ser Gly Gly Tyr 
    370                 375                 380                 


Ser Trp Gln Asp Ala His Ala Asp Val Gly His Leu Val Gly Xaa Leu 
385                 390                 395                 400 


Gly Arg Val Xaa Glu Cys Leu Ser Leu Asp Lys Leu Glu Ala Ala Pro 
                405                 410                 415     


Ser Glu Ala Ala Leu Val Ser Arg Ala Leu Gln Leu Leu Ala Glu His 
            420                 425                 430         


Arg Phe Trp Ala Gly Val Val Phe Leu Gly Pro Glu Asp Ser Ser Asp 
        435                 440                 445             


Pro Xaa Glu His Pro Xaa Pro Asp Leu Gly Pro Gly His Val Arg Ile 
    450                 455                 460                 


Lys Ile Arg Met Asp Ile Asp Val Val Xaa Arg Xaa Asn Lys Ile Arg 
465                 470                 475                 480 


Asp Arg Phe Trp Asp Pro Gly Pro Ala Ala Asp Pro Leu Xaa Asp Leu 
                485                 490                 495     


Arg Tyr Val Trp Gly Gly Phe Val Tyr Leu Gln Asp Leu Val Glu Arg 
            500                 505                 510         


Ala Ala Val Arg Val Leu Ser Gly Ala Asn Pro Arg Ala Gly Leu Tyr 
        515                 520                 525             


Leu Gln Gln Met Pro Tyr Pro Cys Tyr Val Asp Asp Val Phe Leu Arg 
    530                 535                 540                 


Val Leu Ser Arg Ser Leu Pro Leu Phe Leu Xaa Leu Ala Trp Ile Tyr 
545                 550                 555                 560 


Ser Val Xaa Leu Xaa Val Lys Ala Val Val Arg Glu Lys Glu Xaa Arg 
                565                 570                 575     


Leu Arg Asp Xaa Met Arg Ala Met Gly Leu Ser Arg Ala Val Leu Trp 
            580                 585                 590         


Leu Gly Trp Phe Leu Ser Cys Leu Gly Pro Phe Leu Leu Ser Ala Ala 
        595                 600                 605             


Leu Leu Val Leu Val Leu Lys Leu Gly Asp Ile Leu Pro Tyr Ser His 
    610                 615                 620                 


Pro Gly Val Val Phe Leu Phe Leu Ala Ala Phe Ala Val Ala Xaa Val 
625                 630                 635                 640 


Xaa Gln Ser Phe Leu Leu Ser Ala Phe Phe Ser Arg Ala Asn Leu Ala 
                645                 650                 655     


Ala Ala Cys Gly Gly Leu Ala Tyr Phe Ser Leu Tyr Leu Pro Tyr Val 
            660                 665                 670         


Leu Cys Val Ala Trp Arg Asp Arg Leu Pro Ala Gly Gly Arg Val Ala 
        675                 680                 685             


Ala Ser Leu Leu Ser Pro Val Ala Phe Gly Phe Gly Cys Glu Ser Leu 
    690                 695                 700                 


Ala Leu Leu Glu Glu Gln Gly Glu Gly Ala Gln Trp His Asn Val Gly 
705                 710                 715                 720 


Xaa Arg Pro Xaa Ala Asp Val Phe Ser Leu Ala Gln Val Ser Gly Leu 
                725                 730                 735     


Leu Leu Leu Asp Ala Ala Leu Tyr Gly Leu Ala Xaa Trp Tyr Leu Glu 
            740                 745                 750         


Ala Val Cys Pro Gly Gln Tyr Gly Ile Pro Glu Pro Trp Asn Phe Pro 
        755                 760                 765             


Phe Arg Arg Ser Tyr Trp Cys Gly Pro Arg Pro Pro Lys Ser Pro Ala 
    770                 775                 780                 


Pro Cys Pro Xaa Pro Leu Asp Pro Lys Val Leu Val Glu Glu Ala Pro 
785                 790                 795                 800 


Pro Gly Leu Ser Pro Gly Val Ser Val Arg Ser Leu Glu Lys Arg Phe 
                805                 810                 815     


Pro Gly Ser Pro Gln Pro Ala Leu Arg Gly Leu Ser Leu Asp Phe Tyr 
            820                 825                 830         


Gln Gly His Ile Xaa Ala Phe Leu Gly His Asn Gly Ala Gly Lys Xaa 
        835                 840                 845             


Xaa Xaa Leu Ser Ile Leu Ser Gly Leu Phe Pro Pro Ser Gly Gly Ser 
    850                 855                 860                 


Ala Phe Ile Leu Gly His Asp Val Arg Ser Ser Met Ala Ala Ile Arg 
865                 870                 875                 880 


Pro His Leu Gly Val Cys Pro Gln Tyr Asn Val Leu Phe Asp Met Leu 
                885                 890                 895     


Xaa Val Asp Glu His Val Trp Phe Tyr Gly Arg Leu Lys Gly Leu Ser 
            900                 905                 910         


Ala Ala Val Val Gly Pro Glu Gln Asp Arg Leu Leu Gln Asp Val Gly 
        915                 920                 925             


Leu Val Ser Lys Gln Ser Val Gln Xaa Arg His Leu Ser Gly Gly Met 
    930                 935                 940                 


Gln Arg Lys Leu Ser Val Ala Ile Ala Phe Val Gly Gly Ser Gln Val 
945                 950                 955                 960 


Val Ile Leu Asp Glu Pro Xaa Ala Gly Val Asp Pro Ala Ser Arg Arg 
                965                 970                 975     


Gly Ile Trp Glu Leu Leu Leu Lys Tyr Arg Glu Gly Arg Xaa Leu Ile 
            980                 985                 990         


Leu Ser Xaa His His Leu Asp Glu  Ala Glu Leu Leu Gly  Asp Arg Val 
        995                 1000                 1005             


Ala Val  Val Ala Gly Gly Arg  Leu Cys Cys Cys Gly  Ser Pro Leu 
    1010                 1015                 1020             


Phe Leu  Arg Arg His Leu Gly  Ser Gly Tyr Tyr Leu  Xaa Leu Val 
    1025                 1030                 1035             


Lys Ala  Arg Leu Pro Leu Xaa  Xaa Asn Glu Lys Ala  Asp Xaa Asp 
    1040                 1045                 1050             


Met Glu  Gly Ser Val Asp Xaa  Arg Gln Glu Lys Lys  Asn Gly Ser 
    1055                 1060                 1065             


Gln Gly  Ser Arg Val Gly Xaa  Pro Gln Leu Leu Ala  Leu Val Gln 
    1070                 1075                 1080             


His Trp  Val Pro Gly Ala Arg  Leu Val Glu Glu Leu  Pro His Glu 
    1085                 1090                 1095             


Leu Val  Leu Val Leu Pro Tyr  Xaa Gly Ala His Asp  Gly Ser Phe 
    1100                 1105                 1110             


Ala Xaa  Leu Phe Arg Glu Leu  Asp Xaa Arg Leu Ala  Glu Leu Arg 
    1115                 1120                 1125             


Leu Xaa  Gly Tyr Gly Ile Ser  Asp Xaa Ser Leu Glu  Glu Ile Phe 
    1130                 1135                 1140             


Leu Lys  Val Val Glu Glu Cys  Ala Ala Asp Xaa Asp  Met Glu Asp 
    1145                 1150                 1155             


Gly Ser  Cys Gly Gln His Leu  Cys Xaa Gly Ile Ala  Gly Leu Asp 
    1160                 1165                 1170             


Val Xaa  Leu Arg Leu Lys Met  Pro Pro Gln Glu Xaa  Ala Leu Glu 
    1175                 1180                 1185             


Asn Gly  Glu Pro Ala Gly Ser  Ala Pro Glu Xaa Asp  Gln Gly Ser 
    1190                 1195                 1200             


Gly Pro  Asp Ala Val Gly Arg  Val Gln Gly Trp Ala  Leu Xaa Arg 
    1205                 1210                 1215             


Gln Gln  Leu Gln Ala Leu Leu  Leu Lys Arg Phe Leu  Leu Ala Arg 
    1220                 1225                 1230             


Arg Ser  Arg Arg Gly Leu Phe  Ala Gln Ile Val Leu  Pro Ala Leu 
    1235                 1240                 1245             


Phe Val  Gly Leu Ala Leu Val  Phe Ser Leu Ile Val  Pro Pro Phe 
    1250                 1255                 1260             


Gly His  Tyr Pro Ala Leu Arg  Leu Ser Pro Xaa Met  Tyr Gly Ala 
    1265                 1270                 1275             


Gln Val  Ser Phe Phe Ser Glu  Asp Ala Pro Gly Asp  Pro Gly Arg 
    1280                 1285                 1290             


Ala Arg  Leu Leu Glu Ala Leu  Leu Gln Glu Ala Gly  Leu Glu Glu 
    1295                 1300                 1305             


Pro Pro  Val Gln His Ser Ser  His Arg Phe Ser Ala  Pro Glu Val 
    1310                 1315                 1320             


Pro Ala  Glu Val Ala Lys Val  Leu Ala Ser Gly Asn  Trp Xaa Pro 
    1325                 1330                 1335             


Glu Ser  Pro Ser Pro Ala Cys  Gln Cys Ser Arg Pro  Gly Ala Arg 
    1340                 1345                 1350             


Arg Leu  Leu Pro Asp Cys Pro  Ala Ala Ala Gly Gly  Pro Pro Pro 
    1355                 1360                 1365             


Pro Gln  Ala Val Xaa Gly Ser  Gly Glu Val Val Gln  Asn Leu Xaa 
    1370                 1375                 1380             


Gly Arg  Asn Leu Ser Asp Phe  Leu Val Lys Xaa Tyr  Pro Arg Leu 
    1385                 1390                 1395             


Val Arg  Gln Gly Leu Lys Xaa  Lys Lys Trp Val Asn  Glu Val Arg 
    1400                 1405                 1410             


Tyr Gly  Gly Phe Ser Leu Gly  Gly Arg Asp Pro Gly  Leu Pro Ser 
    1415                 1420                 1425             


Gly Gln  Glu Leu Gly Arg Ser  Val Glu Glu Leu Trp  Ala Leu Leu 
    1430                 1435                 1440             


Ser Pro  Leu Pro Gly Gly Ala  Leu Asp Arg Val Leu  Lys Asn Leu 
    1445                 1450                 1455             


Xaa Ala  Trp Ala His Ser Leu  Asp Ala Gln Asp Ser  Leu Lys Ile 
    1460                 1465                 1470             


Trp Phe  Asn Asn Lys Gly Trp  His Ser Met Val Ala  Phe Val Asn 
    1475                 1480                 1485             


Arg Ala  Ser Asn Ala Ile Leu  Arg Ala His Leu Pro  Pro Gly Pro 
    1490                 1495                 1500             


Ala Arg  His Ala His Ser Ile  Xaa Xaa Leu Asn His  Pro Leu Asn 
    1505                 1510                 1515             


Leu Xaa  Lys Glu Gln Leu Ser  Glu Gly Ala Leu Met  Ala Ser Ser 
    1520                 1525                 1530             


Val Asp  Val Leu Val Ser Ile  Cys Val Val Phe Ala  Met Ser Phe 
    1535                 1540                 1545             


Val Pro  Ala Ser Phe Xaa Leu  Val Leu Ile Glu Glu  Arg Val Xaa 
    1550                 1555                 1560             


Arg Ala  Lys His Leu Gln Leu  Met Gly Gly Leu Ser  Pro Xaa Leu 
    1565                 1570                 1575             


Tyr Trp  Leu Gly Asn Phe Leu  Trp Asp Met Cys Asn  Tyr Leu Val 
    1580                 1585                 1590             


Pro Ala  Cys Ile Val Val Leu  Ile Phe Leu Ala Phe  Gln Gln Arg 
    1595                 1600                 1605             


Ala Tyr  Val Ala Pro Ala Asn  Leu Pro Ala Leu Leu  Leu Leu Leu 
    1610                 1615                 1620             


Leu Leu  Tyr Gly Trp Ser Ile  Xaa Pro Leu Met Tyr  Pro Ala Ser 
    1625                 1630                 1635             


Phe Phe  Phe Ser Val Pro Ser  Xaa Ala Tyr Val Val  Leu Xaa Cys 
    1640                 1645                 1650             


Ile Asn  Leu Phe Ile Gly Ile  Asn Gly Ser Met Ala  Xaa Phe Val 
    1655                 1660                 1665             


Leu Glu  Leu Phe Ser Asp Gln  Lys Leu Gln Glu Val  Ser Arg Ile 
    1670                 1675                 1680             


Leu Lys  Gln Val Phe Leu Ile  Phe Pro His Phe Cys  Leu Gly Arg 
    1685                 1690                 1695             


Gly Leu  Ile Asp Met Val Arg  Asn Gln Ala Met Ala  Asp Ala Phe 
    1700                 1705                 1710             


Glu Arg  Leu Gly Asp Arg Gln  Phe Gln Ser Pro Leu  Arg Trp Glu 
    1715                 1720                 1725             


Val Val  Gly Lys Asn Leu Leu  Ala Met Val Ile Gln  Gly Pro Leu 
    1730                 1735                 1740             


Phe Leu  Leu Phe Xaa Leu Leu  Leu Gln His Arg Ser  Gln Leu Leu 
    1745                 1750                 1755             


Pro Gln  Pro Arg Val Arg Ser  Leu Pro Leu Leu Gly  Glu Glu Asp 
    1760                 1765                 1770             


Glu Asp  Val Ala Arg Glu Arg  Glu Arg Val Val Gln  Gly Ala Xaa 
    1775                 1780                 1785             


Gln Gly  Asp Val Leu Val Leu  Arg Asn Leu Xaa Lys  Val Tyr Arg 
    1790                 1795                 1800             


Gly Gln  Arg Met Pro Ala Val  Asp Arg Leu Cys Leu  Gly Ile Pro 
    1805                 1810                 1815             


Pro Gly  Glu Cys Phe Gly Leu  Leu Gly Val Asn Gly  Ala Gly Lys 
    1820                 1825                 1830             


Xaa Ser  Xaa Phe Arg Met Val  Xaa Gly Asp Xaa Leu  Ala Ser Arg 
    1835                 1840                 1845             


Gly Glu  Ala Val Leu Ala Gly  His Ser Val Ala Arg  Glu Pro Ser 
    1850                 1855                 1860             


Ala Ala  His Leu Ser Met Gly  Tyr Cys Pro Gln Ser  Asp Ala Ile 
    1865                 1870                 1875             


Phe Glu  Leu Leu Xaa Gly Arg  Glu His Leu Glu Leu  Leu Ala Arg 
    1880                 1885                 1890             


Leu Arg  Gly Val Pro Glu Ala  Gln Val Ala Gln Xaa  Ala Gly Ser 
    1895                 1900                 1905             


Gly Leu  Ala Arg Leu Gly Leu  Ser Trp Tyr Ala Asp  Arg Pro Ala 
    1910                 1915                 1920             


Gly Xaa  Tyr Ser Gly Gly Asn  Lys Arg Lys Leu Ala  Xaa Ala Leu 
    1925                 1930                 1935             


Ala Leu  Val Gly Asp Pro Ala  Val Val Phe Leu Asp  Glu Pro Xaa 
    1940                 1945                 1950             


Xaa Gly  Met Asp Pro Ser Ala  Arg Arg Phe Leu Trp  Asn Ser Leu 
    1955                 1960                 1965             


Leu Ala  Val Val Arg Glu Gly  Arg Ser Val Met Leu  Xaa Ser His 
    1970                 1975                 1980             


Ser Met  Glu Glu Cys Glu Ala  Leu Cys Ser Arg Leu  Ala Ile Met 
    1985                 1990                 1995             


Val Asn  Gly Arg Phe Arg Cys  Leu Gly Ser Pro Gln  His Leu Lys 
    2000                 2005                 2010             


Gly Arg  Phe Ala Ala Gly His  Xaa Leu Xaa Leu Arg  Val Pro Ala 
    2015                 2020                 2025             


Ala Arg  Ser Gln Pro Ala Ala  Ala Phe Val Ala Ala  Glu Phe Pro 
    2030                 2035                 2040             


Gly Ala  Glu Leu Arg Glu Ala  His Gly Gly Arg Leu  Arg Phe Gln 
    2045                 2050                 2055             


Leu Pro  Pro Gly Gly Arg Cys  Ala Leu Ala Arg Val  Phe Gly Glu 
    2060                 2065                 2070             


Leu Ala  Val His Gly Ala Glu  His Gly Val Glu Asp  Phe Ser Val 
    2075                 2080                 2085             


Ser Gln  Xaa Met Leu Glu Glu  Val Phe Leu Tyr Phe  Ser Lys Asp 
    2090                 2095                 2100             


Gln Gly  Lys Asp Glu Asp Xaa  Glu Glu Gln Lys Glu  Ala Gly Val 
    2105                 2110                 2115             


Gly Val  Asp Pro Ala Pro Gly  Leu Gln His Pro Lys  Arg Val Ser 
    2120                 2125                 2130             


Gln Phe  Leu Asp Asp Pro Ser  Xaa Ala Glu Xaa Val  Leu 
    2135                 2140                 2145     


<210> 1255
<211> 2008
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1235)..(1235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1245)..(1245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1267)..(1267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1321)..(1321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1382)..(1382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1416)..(1416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1425)..(1425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1439)..(1439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1493)..(1493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1508)..(1508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1514)..(1514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1528)..(1528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1610)..(1610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1650)..(1650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1661)..(1661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1696)..(1696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1698)..(1698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1703)..(1703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1706)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1745)..(1745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1767)..(1767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1798)..(1798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1815)..(1816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1843)..(1843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1883)..(1883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1885)..(1885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1953)..(1953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1972)..(1972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2003)..(2003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2006)..(2006)
<223> Selenocysteine

<400> 1255
Met Val Cys Leu Gly Xaa Gly Gln Ser Ala Gly Pro Leu Val Ser Val 
1               5                   10                  15      


Gln Asn His Cys Pro Pro Cys Gly Leu Ser Pro Gln Glu Ser Leu Gly 
            20                  25                  30          


Leu Ala Leu Gly Gln Ala Gln Glu Pro Leu His Ser Leu Leu Glu Ala 
        35                  40                  45              


Ala Glu Asp Leu Ala Gln Glu Leu Leu Ala Leu Arg Ser Leu Val Glu 
    50                  55                  60                  


Leu Arg Ala Leu Leu Gln Arg Pro Arg Gly Xaa Ser Gly Pro Leu Glu 
65                  70                  75                  80  


Leu Leu Ser Glu Ala Leu Cys Ser Val Arg Gly Pro Ser Ser Xaa Val 
                85                  90                  95      


Gly Pro Ser Leu Asn Trp Tyr Glu Ala Ser Asp Leu Met Glu Leu Val 
            100                 105                 110         


Gly Gln Glu Pro Glu Ser Ala Leu Pro Asp Ser Ser Leu Ser Pro Ala 
        115                 120                 125             


Cys Ser Glu Leu Ile Gly Ala Leu Asp Ser His Pro Leu Ser Arg Leu 
    130                 135                 140                 


Leu Trp Arg Arg Leu Lys Pro Leu Ile Leu Gly Lys Leu Leu Phe Ala 
145                 150                 155                 160 


Pro Asp Xaa Pro Phe Xaa Arg Lys Leu Met Ala Gln Val Asn Arg Xaa 
                165                 170                 175     


Phe Glu Glu Leu Xaa Leu Leu Arg Asp Val Arg Glu Val Trp Glu Met 
            180                 185                 190         


Leu Gly Pro Arg Ile Phe Xaa Phe Met Asn Asp Ser Ser Asn Val Ala 
        195                 200                 205             


Met Leu Gln Arg Leu Leu Gln Met Gln Asp Glu Gly Arg Arg Gln Pro 
    210                 215                 220                 


Arg Pro Gly Gly Arg Asp His Met Glu Ala Leu Arg Ser Phe Leu Asp 
225                 230                 235                 240 


Pro Gly Ser Gly Gly Tyr Ser Trp Gln Asp Ala His Ala Asp Val Gly 
                245                 250                 255     


His Leu Val Gly Xaa Leu Gly Arg Val Xaa Glu Cys Leu Ser Leu Asp 
            260                 265                 270         


Lys Leu Glu Ala Ala Pro Ser Glu Ala Ala Leu Val Ser Arg Ala Leu 
        275                 280                 285             


Gln Leu Leu Ala Glu His Arg Phe Trp Ala Gly Val Val Phe Leu Gly 
    290                 295                 300                 


Pro Glu Asp Ser Ser Asp Pro Xaa Glu His Pro Xaa Pro Asp Leu Gly 
305                 310                 315                 320 


Pro Gly His Val Arg Ile Lys Ile Arg Met Asp Ile Asp Val Val Xaa 
                325                 330                 335     


Arg Xaa Asn Lys Ile Arg Asp Arg Phe Trp Asp Pro Gly Pro Ala Ala 
            340                 345                 350         


Asp Pro Leu Xaa Asp Leu Arg Tyr Val Trp Gly Gly Phe Val Tyr Leu 
        355                 360                 365             


Gln Asp Leu Val Glu Arg Ala Ala Val Arg Val Leu Ser Gly Ala Asn 
    370                 375                 380                 


Pro Arg Ala Gly Leu Tyr Leu Gln Gln Met Pro Tyr Pro Cys Tyr Val 
385                 390                 395                 400 


Asp Asp Val Phe Leu Arg Val Leu Ser Arg Ser Leu Pro Leu Phe Leu 
                405                 410                 415     


Xaa Leu Ala Trp Ile Tyr Ser Val Xaa Leu Xaa Val Lys Ala Val Val 
            420                 425                 430         


Arg Glu Lys Glu Xaa Arg Leu Arg Asp Xaa Met Arg Ala Met Gly Leu 
        435                 440                 445             


Ser Arg Ala Val Leu Trp Leu Gly Trp Phe Leu Ser Cys Leu Gly Pro 
    450                 455                 460                 


Phe Leu Leu Ser Ala Ala Leu Leu Val Leu Val Leu Lys Leu Gly Asp 
465                 470                 475                 480 


Ile Leu Pro Tyr Ser His Pro Gly Val Val Phe Leu Phe Leu Ala Ala 
                485                 490                 495     


Phe Ala Val Ala Xaa Val Xaa Gln Ser Phe Leu Leu Ser Ala Phe Phe 
            500                 505                 510         


Ser Arg Ala Asn Leu Ala Ala Ala Cys Gly Gly Leu Ala Tyr Phe Ser 
        515                 520                 525             


Leu Tyr Leu Pro Tyr Val Leu Cys Val Ala Trp Arg Asp Arg Leu Pro 
    530                 535                 540                 


Ala Gly Gly Arg Val Ala Ala Ser Leu Leu Ser Pro Val Ala Phe Gly 
545                 550                 555                 560 


Phe Gly Cys Glu Ser Leu Ala Leu Leu Glu Glu Gln Gly Glu Gly Ala 
                565                 570                 575     


Gln Trp His Asn Val Gly Xaa Arg Pro Xaa Ala Asp Val Phe Ser Leu 
            580                 585                 590         


Ala Gln Val Ser Gly Leu Leu Leu Leu Asp Ala Ala Leu Tyr Gly Leu 
        595                 600                 605             


Ala Xaa Trp Tyr Leu Glu Ala Val Cys Pro Gly Gln Tyr Gly Ile Pro 
    610                 615                 620                 


Glu Pro Trp Asn Phe Pro Phe Arg Arg Ser Tyr Trp Cys Gly Pro Arg 
625                 630                 635                 640 


Pro Pro Lys Ser Pro Ala Pro Cys Pro Xaa Pro Leu Asp Pro Lys Val 
                645                 650                 655     


Leu Val Glu Glu Ala Pro Pro Gly Leu Ser Pro Gly Val Ser Val Arg 
            660                 665                 670         


Ser Leu Glu Lys Arg Phe Pro Gly Ser Pro Gln Pro Ala Leu Arg Gly 
        675                 680                 685             


Leu Ser Leu Asp Phe Tyr Gln Gly His Ile Xaa Ala Phe Leu Gly His 
    690                 695                 700                 


Asn Gly Ala Gly Lys Xaa Xaa Xaa Leu Ser Ile Leu Ser Gly Leu Phe 
705                 710                 715                 720 


Pro Pro Ser Gly Gly Ser Ala Phe Ile Leu Gly His Asp Val Arg Ser 
                725                 730                 735     


Ser Met Ala Ala Ile Arg Pro His Leu Gly Val Cys Pro Gln Tyr Asn 
            740                 745                 750         


Val Leu Phe Asp Met Leu Xaa Val Asp Glu His Val Trp Phe Tyr Gly 
        755                 760                 765             


Arg Leu Lys Gly Leu Ser Ala Ala Val Val Gly Pro Glu Gln Asp Arg 
    770                 775                 780                 


Leu Leu Gln Asp Val Gly Leu Val Ser Lys Gln Ser Val Gln Xaa Arg 
785                 790                 795                 800 


His Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val Ala Ile Ala Phe 
                805                 810                 815     


Val Gly Gly Ser Gln Val Val Ile Leu Asp Glu Pro Xaa Ala Gly Val 
            820                 825                 830         


Asp Pro Ala Ser Arg Arg Gly Ile Trp Glu Leu Leu Leu Lys Tyr Arg 
        835                 840                 845             


Glu Gly Arg Xaa Leu Ile Leu Ser Xaa His His Leu Asp Glu Ala Glu 
    850                 855                 860                 


Leu Leu Gly Asp Arg Val Ala Val Val Ala Gly Gly Arg Leu Cys Cys 
865                 870                 875                 880 


Cys Gly Ser Pro Leu Phe Leu Arg Arg His Leu Gly Ser Gly Tyr Tyr 
                885                 890                 895     


Leu Xaa Leu Val Lys Ala Arg Leu Pro Leu Xaa Xaa Asn Glu Lys Ala 
            900                 905                 910         


Asp Xaa Asp Met Glu Gly Ser Val Asp Xaa Arg Gln Glu Lys Lys Asn 
        915                 920                 925             


Gly Ser Gln Gly Ser Arg Val Gly Xaa Pro Gln Leu Leu Ala Leu Val 
    930                 935                 940                 


Gln His Trp Val Pro Gly Ala Arg Leu Val Glu Glu Leu Pro His Glu 
945                 950                 955                 960 


Leu Val Leu Val Leu Pro Tyr Xaa Gly Ala His Asp Gly Ser Phe Ala 
                965                 970                 975     


Xaa Leu Phe Arg Glu Leu Asp Xaa Arg Leu Ala Glu Leu Arg Leu Xaa 
            980                 985                 990         


Gly Tyr Gly Ile Ser Asp Xaa Ser  Leu Glu Glu Ile Phe  Leu Lys Val 
        995                 1000                 1005             


Val Glu  Glu Cys Ala Ala Asp  Xaa Asp Met Glu Asp  Gly Ser Cys 
    1010                 1015                 1020             


Gly Gln  His Leu Cys Xaa Gly  Ile Ala Gly Leu Asp  Val Xaa Leu 
    1025                 1030                 1035             


Arg Leu  Lys Met Pro Pro Gln  Glu Xaa Ala Leu Glu  Asn Gly Glu 
    1040                 1045                 1050             


Pro Ala  Gly Ser Ala Pro Glu  Xaa Asp Gln Gly Ser  Gly Pro Asp 
    1055                 1060                 1065             


Ala Val  Gly Arg Val Gln Gly  Trp Ala Leu Xaa Arg  Gln Gln Leu 
    1070                 1075                 1080             


Gln Ala  Leu Leu Leu Lys Arg  Phe Leu Leu Ala Arg  Arg Ser Arg 
    1085                 1090                 1095             


Arg Gly  Leu Phe Ala Gln Ile  Val Leu Pro Ala Leu  Phe Val Gly 
    1100                 1105                 1110             


Leu Ala  Leu Val Phe Ser Leu  Ile Val Pro Pro Phe  Gly His Tyr 
    1115                 1120                 1125             


Pro Ala  Leu Arg Leu Ser Pro  Xaa Met Tyr Gly Ala  Gln Val Ser 
    1130                 1135                 1140             


Phe Phe  Ser Glu Asp Ala Pro  Gly Asp Pro Gly Arg  Ala Arg Leu 
    1145                 1150                 1155             


Leu Glu  Ala Leu Leu Gln Glu  Ala Gly Leu Glu Glu  Pro Pro Val 
    1160                 1165                 1170             


Gln His  Ser Ser His Arg Phe  Ser Ala Pro Glu Val  Pro Ala Glu 
    1175                 1180                 1185             


Val Ala  Lys Val Leu Ala Ser  Gly Asn Trp Xaa Pro  Glu Ser Pro 
    1190                 1195                 1200             


Ser Pro  Ala Cys Gln Cys Ser  Arg Pro Gly Ala Arg  Arg Leu Leu 
    1205                 1210                 1215             


Pro Asp  Cys Pro Ala Ala Ala  Gly Gly Pro Pro Pro  Pro Gln Ala 
    1220                 1225                 1230             


Val Xaa  Gly Ser Gly Glu Val  Val Gln Asn Leu Xaa  Gly Arg Asn 
    1235                 1240                 1245             


Leu Ser  Asp Phe Leu Val Lys  Xaa Tyr Pro Arg Leu  Val Arg Gln 
    1250                 1255                 1260             


Gly Leu  Lys Xaa Lys Lys Trp  Val Asn Glu Val Arg  Tyr Gly Gly 
    1265                 1270                 1275             


Phe Ser  Leu Gly Gly Arg Asp  Pro Gly Leu Pro Ser  Gly Gln Glu 
    1280                 1285                 1290             


Leu Gly  Arg Ser Val Glu Glu  Leu Trp Ala Leu Leu  Ser Pro Leu 
    1295                 1300                 1305             


Pro Gly  Gly Ala Leu Asp Arg  Val Leu Lys Asn Leu  Xaa Ala Trp 
    1310                 1315                 1320             


Ala His  Ser Leu Asp Ala Gln  Asp Ser Leu Lys Ile  Trp Phe Asn 
    1325                 1330                 1335             


Asn Lys  Gly Trp His Ser Met  Val Ala Phe Val Asn  Arg Ala Ser 
    1340                 1345                 1350             


Asn Ala  Ile Leu Arg Ala His  Leu Pro Pro Gly Pro  Ala Arg His 
    1355                 1360                 1365             


Ala His  Ser Ile Xaa Xaa Leu  Asn His Pro Leu Asn  Leu Xaa Lys 
    1370                 1375                 1380             


Glu Gln  Leu Ser Glu Gly Ala  Leu Met Ala Ser Ser  Val Asp Val 
    1385                 1390                 1395             


Leu Val  Ser Ile Cys Val Val  Phe Ala Met Ser Phe  Val Pro Ala 
    1400                 1405                 1410             


Ser Phe  Xaa Leu Val Leu Ile  Glu Glu Arg Val Xaa  Arg Ala Lys 
    1415                 1420                 1425             


His Leu  Gln Leu Met Gly Gly  Leu Ser Pro Xaa Leu  Tyr Trp Leu 
    1430                 1435                 1440             


Gly Asn  Phe Leu Trp Asp Met  Cys Asn Tyr Leu Val  Pro Ala Cys 
    1445                 1450                 1455             


Ile Val  Val Leu Ile Phe Leu  Ala Phe Gln Gln Arg  Ala Tyr Val 
    1460                 1465                 1470             


Ala Pro  Ala Asn Leu Pro Ala  Leu Leu Leu Leu Leu  Leu Leu Tyr 
    1475                 1480                 1485             


Gly Trp  Ser Ile Xaa Pro Leu  Met Tyr Pro Ala Ser  Phe Phe Phe 
    1490                 1495                 1500             


Ser Val  Pro Ser Xaa Ala Tyr  Val Val Leu Xaa Cys  Ile Asn Leu 
    1505                 1510                 1515             


Phe Ile  Gly Ile Asn Gly Ser  Met Ala Xaa Phe Val  Leu Glu Leu 
    1520                 1525                 1530             


Phe Ser  Asp Gln Lys Leu Gln  Glu Val Ser Arg Ile  Leu Lys Gln 
    1535                 1540                 1545             


Val Phe  Leu Ile Phe Pro His  Phe Cys Leu Gly Arg  Gly Leu Ile 
    1550                 1555                 1560             


Asp Met  Val Arg Asn Gln Ala  Met Ala Asp Ala Phe  Glu Arg Leu 
    1565                 1570                 1575             


Gly Asp  Arg Gln Phe Gln Ser  Pro Leu Arg Trp Glu  Val Val Gly 
    1580                 1585                 1590             


Lys Asn  Leu Leu Ala Met Val  Ile Gln Gly Pro Leu  Phe Leu Leu 
    1595                 1600                 1605             


Phe Xaa  Leu Leu Leu Gln His  Arg Ser Gln Leu Leu  Pro Gln Pro 
    1610                 1615                 1620             


Arg Val  Arg Ser Leu Pro Leu  Leu Gly Glu Glu Asp  Glu Asp Val 
    1625                 1630                 1635             


Ala Arg  Glu Arg Glu Arg Val  Val Gln Gly Ala Xaa  Gln Gly Asp 
    1640                 1645                 1650             


Val Leu  Val Leu Arg Asn Leu  Xaa Lys Val Tyr Arg  Gly Gln Arg 
    1655                 1660                 1665             


Met Pro  Ala Val Asp Arg Leu  Cys Leu Gly Ile Pro  Pro Gly Glu 
    1670                 1675                 1680             


Cys Phe  Gly Leu Leu Gly Val  Asn Gly Ala Gly Lys  Xaa Ser Xaa 
    1685                 1690                 1695             


Phe Arg  Met Val Xaa Gly Asp  Xaa Leu Ala Ser Arg  Gly Glu Ala 
    1700                 1705                 1710             


Val Leu  Ala Gly His Ser Val  Ala Arg Glu Pro Ser  Ala Ala His 
    1715                 1720                 1725             


Leu Ser  Met Gly Tyr Cys Pro  Gln Ser Asp Ala Ile  Phe Glu Leu 
    1730                 1735                 1740             


Leu Xaa  Gly Arg Glu His Leu  Glu Leu Leu Ala Arg  Leu Arg Gly 
    1745                 1750                 1755             


Val Pro  Glu Ala Gln Val Ala  Gln Xaa Ala Gly Ser  Gly Leu Ala 
    1760                 1765                 1770             


Arg Leu  Gly Leu Ser Trp Tyr  Ala Asp Arg Pro Ala  Gly Xaa Tyr 
    1775                 1780                 1785             


Ser Gly  Gly Asn Lys Arg Lys  Leu Ala Xaa Ala Leu  Ala Leu Val 
    1790                 1795                 1800             


Gly Asp  Pro Ala Val Val Phe  Leu Asp Glu Pro Xaa  Xaa Gly Met 
    1805                 1810                 1815             


Asp Pro  Ser Ala Arg Arg Phe  Leu Trp Asn Ser Leu  Leu Ala Val 
    1820                 1825                 1830             


Val Arg  Glu Gly Arg Ser Val  Met Leu Xaa Ser His  Ser Met Glu 
    1835                 1840                 1845             


Glu Cys  Glu Ala Leu Cys Ser  Arg Leu Ala Ile Met  Val Asn Gly 
    1850                 1855                 1860             


Arg Phe  Arg Cys Leu Gly Ser  Pro Gln His Leu Lys  Gly Arg Phe 
    1865                 1870                 1875             


Ala Ala  Gly His Xaa Leu Xaa  Leu Arg Val Pro Ala  Ala Arg Ser 
    1880                 1885                 1890             


Gln Pro  Ala Ala Ala Phe Val  Ala Ala Glu Phe Pro  Gly Ala Glu 
    1895                 1900                 1905             


Leu Arg  Glu Ala His Gly Gly  Arg Leu Arg Phe Gln  Leu Pro Pro 
    1910                 1915                 1920             


Gly Gly  Arg Cys Ala Leu Ala  Arg Val Phe Gly Glu  Leu Ala Val 
    1925                 1930                 1935             


His Gly  Ala Glu His Gly Val  Glu Asp Phe Ser Val  Ser Gln Xaa 
    1940                 1945                 1950             


Met Leu  Glu Glu Val Phe Leu  Tyr Phe Ser Lys Asp  Gln Gly Lys 
    1955                 1960                 1965             


Asp Glu  Asp Xaa Glu Glu Gln  Lys Glu Ala Gly Val  Gly Val Asp 
    1970                 1975                 1980             


Pro Ala  Pro Gly Leu Gln His  Pro Lys Arg Val Ser  Gln Phe Leu 
    1985                 1990                 1995             


Asp Asp  Pro Ser Xaa Ala Glu  Xaa Val Leu 
    2000                 2005             


<210> 1256
<211> 280
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<400> 1256
Arg Glu Pro Ser Ala Ala His Leu Ser Met Gly Tyr Cys Pro Gln Ser 
1               5                   10                  15      


Asp Ala Ile Phe Glu Leu Leu Xaa Gly Arg Glu His Leu Glu Leu Leu 
            20                  25                  30          


Ala Arg Leu Arg Gly Val Pro Glu Ala Gln Val Ala Gln Xaa Ala Gly 
        35                  40                  45              


Ser Gly Leu Ala Arg Leu Gly Leu Ser Trp Tyr Ala Asp Arg Pro Ala 
    50                  55                  60                  


Gly Xaa Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ala Xaa Ala Leu Ala 
65                  70                  75                  80  


Leu Val Gly Asp Pro Ala Val Val Phe Leu Asp Glu Pro Xaa Xaa Gly 
                85                  90                  95      


Met Asp Pro Ser Ala Arg Arg Phe Leu Trp Asn Ser Leu Leu Ala Val 
            100                 105                 110         


Val Arg Glu Gly Arg Ser Val Met Leu Xaa Ser His Ser Met Glu Glu 
        115                 120                 125             


Cys Glu Ala Leu Cys Ser Arg Leu Ala Ile Met Val Asn Gly Arg Phe 
    130                 135                 140                 


Arg Cys Leu Gly Ser Pro Gln His Leu Lys Gly Arg Phe Ala Ala Gly 
145                 150                 155                 160 


His Xaa Leu Xaa Leu Arg Val Pro Ala Ala Arg Ser Gln Pro Ala Ala 
                165                 170                 175     


Ala Phe Val Ala Ala Glu Phe Pro Gly Ala Glu Leu Arg Glu Ala His 
            180                 185                 190         


Gly Gly Arg Leu Arg Phe Gln Leu Pro Pro Gly Gly Arg Cys Ala Leu 
        195                 200                 205             


Ala Arg Val Phe Gly Glu Leu Ala Val His Gly Ala Glu His Gly Val 
    210                 215                 220                 


Glu Asp Phe Ser Val Ser Gln Xaa Met Leu Glu Glu Asp Gln Gly Lys 
225                 230                 235                 240 


Asp Glu Asp Xaa Glu Glu Gln Lys Glu Ala Gly Val Gly Val Asp Pro 
                245                 250                 255     


Ala Pro Gly Leu Gln His Pro Lys Arg Val Ser Gln Phe Leu Asp Asp 
            260                 265                 270         


Pro Ser Xaa Ala Glu Xaa Val Leu 
        275                 280 


<210> 1257
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<400> 1257
Xaa Leu Val Ser Ile Cys Val Val Phe Ala Met Ser Phe Val Pro Ala 
1               5                   10                  15      


Ser Phe Xaa Leu Val Leu Ile Glu Glu Arg Val Xaa Arg Ala Lys His 
            20                  25                  30          


Leu Gln Leu Met Gly Gly Leu Ser Pro Xaa Leu Tyr Trp Leu Gly Asn 
        35                  40                  45              


Phe Leu Trp Asp Met Cys Asn Tyr Leu Val Pro Ala Cys Ile Val Val 
    50                  55                  60                  


Leu Ile Phe Leu Ala Phe Gln Gln Arg Ala Tyr Val Ala Pro Ala Asn 
65                  70                  75                  80  


Leu Pro Ala Leu Leu Leu Leu Leu Leu Leu Tyr Gly Ser Cys Arg Arg 
                85                  90                  95      


<210> 1258
<211> 62
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<400> 1258
Xaa Pro Gln Glu Xaa Ala Leu Glu Asn Gly Glu Pro Ala Gly Ser Ala 
1               5                   10                  15      


Pro Glu Xaa Asp Gln Gly Ser Gly Pro Asp Ala Val Gly Arg Val Gln 
            20                  25                  30          


Gly Trp Ala Leu Xaa Arg Gln Gln Leu Gln Ala Leu Leu Leu Lys Arg 
        35                  40                  45              


Phe Leu Leu Ala Arg Arg Ser Arg Arg Gly Leu Phe Ala Gln 
    50                  55                  60          


<210> 1259
<211> 591
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<400> 1259
Xaa Ser Ile Cys Val Val Phe Ala Met Ser Phe Val Pro Ala Ser Phe 
1               5                   10                  15      


Xaa Leu Val Leu Ile Glu Glu Arg Val Xaa Arg Ala Lys His Leu Gln 
            20                  25                  30          


Leu Met Gly Gly Leu Ser Pro Xaa Leu Tyr Trp Leu Gly Asn Phe Leu 
        35                  40                  45              


Trp Asp Met Cys Asn Tyr Leu Val Pro Ala Cys Ile Val Val Leu Ile 
    50                  55                  60                  


Phe Leu Ala Phe Gln Gln Arg Ala Tyr Val Ala Pro Ala Asn Leu Pro 
65                  70                  75                  80  


Ala Leu Leu Leu Leu Leu Leu Leu Tyr Gly Xaa Ala Tyr Val Val Leu 
                85                  90                  95      


Xaa Cys Ile Asn Leu Phe Ile Gly Ile Asn Gly Ser Met Ala Xaa Phe 
            100                 105                 110         


Val Leu Glu Leu Phe Ser Asp Gln Lys Leu Gln Glu Val Ser Arg Ile 
        115                 120                 125             


Leu Lys Gln Val Phe Leu Ile Phe Pro His Phe Cys Leu Gly Arg Gly 
    130                 135                 140                 


Leu Ile Asp Met Val Arg Asn Gln Ala Met Ala Asp Ala Phe Glu Arg 
145                 150                 155                 160 


Leu Gly Asp Arg Gln Phe Gln Ser Pro Leu Arg Trp Glu Val Val Gly 
                165                 170                 175     


Lys Asn Leu Leu Ala Met Val Ile Gln Gly Pro Leu Phe Leu Leu Phe 
            180                 185                 190         


Xaa Leu Leu Leu Gln His Arg Ser Gln Leu Leu Pro Gln Pro Arg Val 
        195                 200                 205             


Arg Ser Leu Pro Leu Leu Gly Glu Glu Asp Glu Asp Val Ala Arg Glu 
    210                 215                 220                 


Arg Glu Arg Val Val Gln Gly Ala Xaa Gln Gly Asp Val Leu Val Leu 
225                 230                 235                 240 


Arg Asn Leu Xaa Lys Val Tyr Arg Gly Gln Arg Met Pro Ala Val Asp 
                245                 250                 255     


Arg Leu Cys Leu Gly Ile Pro Pro Gly Glu Cys Phe Gly Leu Leu Gly 
            260                 265                 270         


Val Asn Gly Ala Gly Lys Xaa Ser Xaa Phe Arg Met Val Xaa Gly Asp 
        275                 280                 285             


Xaa Leu Ala Ser Arg Gly Glu Ala Val Leu Ala Gly His Ser Val Ala 
    290                 295                 300                 


Arg Glu Pro Ser Ala Ala His Leu Ser Met Gly Tyr Cys Pro Gln Ser 
305                 310                 315                 320 


Asp Ala Ile Phe Glu Leu Leu Xaa Gly Arg Glu His Leu Glu Leu Leu 
                325                 330                 335     


Ala Arg Leu Arg Gly Val Pro Glu Ala Gln Val Ala Gln Xaa Ala Gly 
            340                 345                 350         


Ser Gly Leu Ala Arg Leu Gly Leu Ser Trp Tyr Ala Asp Arg Pro Ala 
        355                 360                 365             


Gly Xaa Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ala Xaa Ala Leu Ala 
    370                 375                 380                 


Leu Val Gly Asp Pro Ala Val Val Phe Leu Asp Glu Pro Xaa Xaa Gly 
385                 390                 395                 400 


Met Asp Pro Ser Ala Arg Arg Phe Leu Trp Asn Ser Leu Leu Ala Val 
                405                 410                 415     


Val Arg Glu Gly Arg Ser Val Met Leu Xaa Ser His Ser Met Glu Glu 
            420                 425                 430         


Cys Glu Ala Leu Cys Ser Arg Leu Ala Ile Met Val Asn Gly Arg Phe 
        435                 440                 445             


Arg Cys Leu Gly Ser Pro Gln His Leu Lys Gly Arg Phe Ala Ala Gly 
    450                 455                 460                 


His Xaa Leu Xaa Leu Arg Val Pro Ala Ala Arg Ser Gln Pro Ala Ala 
465                 470                 475                 480 


Ala Phe Val Ala Ala Glu Phe Pro Gly Ala Glu Leu Arg Glu Ala His 
                485                 490                 495     


Gly Gly Arg Leu Arg Phe Gln Leu Pro Pro Gly Gly Arg Cys Ala Leu 
            500                 505                 510         


Ala Arg Val Phe Gly Glu Leu Ala Val His Gly Ala Glu His Gly Val 
        515                 520                 525             


Glu Asp Phe Ser Val Ser Gln Xaa Met Leu Glu Glu Val Phe Leu Tyr 
    530                 535                 540                 


Phe Ser Lys Asp Gln Gly Lys Asp Glu Asp Xaa Glu Glu Gln Lys Glu 
545                 550                 555                 560 


Ala Gly Val Gly Val Asp Pro Ala Pro Gly Leu Gln His Pro Lys Arg 
                565                 570                 575     


Val Ser Gln Phe Leu Asp Asp Pro Ser Xaa Ala Glu Xaa Val Leu 
            580                 585                 590     


<210> 1260
<211> 50
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<400> 1260
Met Pro Leu Ala Phe Cys Gly Ser Glu Asn His Ser Ala Ala Tyr Arg 
1               5                   10                  15      


Val Asp Gln Gly Val Leu Asn Asn Gly Cys Phe Val Asp Ala Leu Asn 
            20                  25                  30          


Val Val Pro His Val Phe Leu Leu Phe Ile Xaa Phe Pro Ile Leu Phe 
        35                  40                  45              


Ile Gly 
    50  


<210> 1261
<211> 997
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<400> 1261
Met Pro Leu Ala Phe Cys Gly Ser Glu Asn His Ser Ala Ala Tyr Arg 
1               5                   10                  15      


Val Asp Gln Gly Val Leu Asn Asn Gly Cys Phe Val Asp Ala Leu Asn 
            20                  25                  30          


Val Val Pro His Val Phe Leu Leu Phe Ile Xaa Phe Pro Ile Leu Phe 
        35                  40                  45              


Ile Gly Trp Gly Ser Gln Ser Ser Lys Val His Ile His His Ser Xaa 
    50                  55                  60                  


Trp Leu His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Xaa Phe Met 
65                  70                  75                  80  


Leu Leu Phe Val Leu Val Cys Glu Ile Ala Glu Gly Ile Leu Ser Asp 
                85                  90                  95      


Gly Val Xaa Glu Ser His His Leu His Leu Tyr Met Pro Ala Gly Met 
            100                 105                 110         


Ala Phe Met Ala Ala Val Xaa Ser Val Val Tyr Tyr His Asn Ile Glu 
        115                 120                 125             


Xaa Ser Asn Phe Pro Lys Leu Leu Ile Ala Leu Leu Val Tyr Trp Xaa 
    130                 135                 140                 


Leu Ala Phe Ile Xaa Lys Xaa Ile Lys Phe Val Lys Phe Leu Asp His 
145                 150                 155                 160 


Ala Ile Gly Phe Ser Gln Leu Arg Phe Cys Leu Xaa Gly Leu Leu Val 
                165                 170                 175     


Ile Leu Tyr Gly Met Leu Leu Leu Val Glu Val Asn Val Ile Arg Val 
            180                 185                 190         


Arg Arg Tyr Ile Phe Phe Lys Xaa Pro Arg Glu Val Lys Pro Pro Glu 
        195                 200                 205             


Asp Leu Gln Asp Leu Gly Val Arg Phe Leu Gln Pro Phe Val Asn Leu 
    210                 215                 220                 


Leu Ser Lys Gly Xaa Tyr Trp Trp Met Asn Ala Phe Ile Lys Xaa Ala 
225                 230                 235                 240 


His Lys Lys Pro Ile Asp Leu Arg Ala Ile Gly Lys Leu Pro Ile Ala 
                245                 250                 255     


Met Arg Ala Leu Xaa Asn Tyr Gln Arg Leu Cys Glu Ala Phe Asp Ala 
            260                 265                 270         


Gln Val Arg Lys Asp Ile Gln Gly Xaa Gln Gly Ala Arg Ala Ile Trp 
        275                 280                 285             


Gln Ala Leu Ser His Ala Phe Gly Arg Arg Leu Val Leu Ser Ser Xaa 
    290                 295                 300                 


Phe Arg Ile Leu Ala Asp Leu Leu Gly Phe Ala Gly Pro Leu Cys Ile 
305                 310                 315                 320 


Phe Gly Ile Val Asp His Leu Gly Lys Glu Asn Asp Val Phe Gln Pro 
                325                 330                 335     


Lys Xaa Gln Phe Leu Gly Val Tyr Phe Val Ser Ser Gln Glu Phe Leu 
            340                 345                 350         


Ala Asn Ala Tyr Val Leu Ala Val Leu Leu Phe Leu Ala Leu Leu Leu 
        355                 360                 365             


Gln Arg Xaa Phe Leu Gln Ala Ser Tyr Tyr Val Ala Ile Glu Xaa Gly 
    370                 375                 380                 


Ile Asn Leu Arg Gly Ala Ile Gln Xaa Lys Ile Tyr Asn Lys Ile Met 
385                 390                 395                 400 


His Leu Ser Xaa Ser Asn Leu Ser Met Gly Glu Met Xaa Ala Gly Gln 
                405                 410                 415     


Ile Cys Asn Leu Val Ala Ile Asp Xaa Asn Gln Leu Met Trp Phe Phe 
            420                 425                 430         


Phe Leu Cys Pro Asn Leu Trp Ala Met Pro Val Gln Ile Ile Val Gly 
        435                 440                 445             


Val Ile Leu Leu Tyr Tyr Ile Leu Gly Val Ser Ala Leu Ile Gly Ala 
    450                 455                 460                 


Ala Val Ile Ile Leu Leu Ala Pro Val Gln Tyr Phe Val Ala Xaa Lys 
465                 470                 475                 480 


Leu Ser Gln Ala Gln Arg Ser Xaa Leu Glu Tyr Ser Asn Glu Arg Leu 
                485                 490                 495     


Lys Gln Xaa Asn Glu Met Leu Arg Gly Ile Lys Leu Leu Lys Leu Tyr 
            500                 505                 510         


Ala Trp Glu Asn Ile Phe Arg Xaa Arg Val Glu Xaa Xaa Arg Arg Lys 
        515                 520                 525             


Glu Met Xaa Ser Leu Arg Ala Phe Ala Ile Tyr Xaa Ser Ile Ser Ile 
    530                 535                 540                 


Phe Met Asn Xaa Ala Ile Pro Ile Ala Ala Val Leu Ile Xaa Phe Val 
545                 550                 555                 560 


Gly His Val Ser Phe Phe Lys Glu Ala Asp Phe Ser Pro Ser Val Ala 
                565                 570                 575     


Phe Ala Ser Leu Ser Leu Phe His Ile Leu Val Xaa Pro Leu Phe Leu 
            580                 585                 590         


Leu Ser Ser Val Val Arg Ser Xaa Val Lys Ala Leu Val Ser Ala Glu 
        595                 600                 605             


Ile Arg Glu Glu Gln Cys Ala Pro His Glu Pro Xaa Pro Gln Gly Pro 
    610                 615                 620                 


Ala Ser Lys Tyr Gln Ala Val Pro Leu Arg Val Val Asn Arg Lys Arg 
625                 630                 635                 640 


Pro Ala Arg Glu Asp Cys Arg Gly Leu Xaa Gly Pro Leu Gln Ser Leu 
                645                 650                 655     


Val Pro Ser Ala Asp Gly Asp Ala Asp Asn Cys Cys Val Gln Ile Met 
            660                 665                 670         


Gly Gly Tyr Phe Xaa Trp Xaa Pro Asp Gly Ile Pro Xaa Leu Ser Asn 
        675                 680                 685             


Ile Xaa Ile Arg Ile Pro Arg Gly Gln Leu Xaa Met Ile Val Gly Gln 
    690                 695                 700                 


Val Gly Cys Gly Lys Ser Ser Leu Leu Leu Ala Ala Leu Gly Glu Met 
705                 710                 715                 720 


Gln Lys Val Ser Gly Ala Val Phe Trp Ser Ser Leu Pro Asp Ser Glu 
                725                 730                 735     


Ile Gly Glu Asp Pro Ser Pro Glu Arg Glu Xaa Ala Xaa Asp Leu Asp 
            740                 745                 750         


Ile Arg Lys Arg Gly Pro Val Ala Tyr Ala Ser Gln Lys Pro Trp Leu 
        755                 760                 765             


Leu Asn Ala Xaa Val Glu Glu Asn Ile Ile Phe Glu Ser Pro Phe Asn 
    770                 775                 780                 


Lys Gln Arg Tyr Lys Met Val Ile Glu Ala Cys Ser Leu Gln Pro Asp 
785                 790                 795                 800 


Ile Asp Ile Leu Pro His Gly Asp Gln Xaa Gln Ile Gly Glu Arg Gly 
                805                 810                 815     


Ile Asn Leu Ser Gly Gly Gln Arg Gln Arg Ile Ser Val Ala Arg Ala 
            820                 825                 830         


Leu Tyr Gln His Ala Asn Val Val Phe Leu Asp Asp Pro Phe Ser Ala 
        835                 840                 845             


Leu Asp Ile His Leu Ser Asp His Leu Met Gln Ala Gly Ile Leu Glu 
    850                 855                 860                 


Leu Leu Arg Asp Asp Lys Arg Xaa Val Val Leu Val Xaa His Lys Leu 
865                 870                 875                 880 


Gln Tyr Leu Pro His Ala Asp Trp Ile Ile Ala Met Lys Asp Gly Xaa 
                885                 890                 895     


Ile Gln Arg Glu Gly Xaa Leu Lys Asp Phe Gln Arg Ser Glu Cys Gln 
            900                 905                 910         


Leu Phe Glu His Trp Lys Xaa Leu Met Asn Arg Gln Asp Gln Glu Leu 
        915                 920                 925             


Glu Lys Arg Arg Gln Leu Arg Ala Arg Arg Met Xaa Xaa Cys Arg Pro 
    930                 935                 940                 


Cys Cys Xaa Ser Val Leu Arg Ser His Gly Glu Pro Ala Pro Ser Xaa 
945                 950                 955                 960 


Cys Pro Pro Pro Ala Ser Cys Ser Cys Arg Cys Trp Ser Ser His Ser 
                965                 970                 975     


Cys Ser Ser Xaa Trp Ser Trp Trp Pro Ser Xaa Xaa Gly Trp Pro Ser 
            980                 985                 990         


Gly Pro Xaa Ala Pro 
        995         


<210> 1262
<211> 1581
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1138)..(1138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1206)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1211)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1320)..(1320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1380)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1397)..(1397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1416)..(1416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1449)..(1449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1475)..(1475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1499)..(1499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1508)..(1508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1515)..(1515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1525)..(1525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1531)..(1531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1534)..(1534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1541)..(1541)
<223> Selenocysteine

<400> 1262
Met Pro Leu Ala Phe Cys Gly Ser Glu Asn His Ser Ala Ala Tyr Arg 
1               5                   10                  15      


Val Asp Gln Gly Val Leu Asn Asn Gly Cys Phe Val Asp Ala Leu Asn 
            20                  25                  30          


Val Val Pro His Val Phe Leu Leu Phe Ile Xaa Phe Pro Ile Leu Phe 
        35                  40                  45              


Ile Gly Trp Gly Ser Gln Ser Ser Lys Val His Ile His His Ser Xaa 
    50                  55                  60                  


Trp Leu His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Xaa Phe Met 
65                  70                  75                  80  


Leu Leu Phe Val Leu Val Cys Glu Ile Ala Glu Gly Ile Leu Ser Asp 
                85                  90                  95      


Gly Val Xaa Glu Ser His His Leu His Leu Tyr Met Pro Ala Gly Met 
            100                 105                 110         


Ala Phe Met Ala Ala Val Xaa Ser Val Val Tyr Tyr His Asn Ile Glu 
        115                 120                 125             


Xaa Ser Asn Phe Pro Lys Leu Leu Ile Ala Leu Leu Val Tyr Trp Xaa 
    130                 135                 140                 


Leu Ala Phe Ile Xaa Lys Xaa Ile Lys Phe Val Lys Phe Leu Asp His 
145                 150                 155                 160 


Ala Ile Gly Phe Ser Gln Leu Arg Phe Cys Leu Xaa Gly Leu Leu Val 
                165                 170                 175     


Ile Leu Tyr Gly Met Leu Leu Leu Val Glu Val Asn Val Ile Arg Val 
            180                 185                 190         


Arg Arg Tyr Ile Phe Phe Lys Xaa Pro Arg Glu Val Lys Pro Pro Glu 
        195                 200                 205             


Asp Leu Gln Asp Leu Gly Val Arg Phe Leu Gln Pro Phe Val Asn Leu 
    210                 215                 220                 


Leu Ser Lys Gly Xaa Tyr Trp Trp Met Asn Ala Phe Ile Lys Xaa Ala 
225                 230                 235                 240 


His Lys Lys Pro Ile Asp Leu Arg Ala Ile Gly Lys Leu Pro Ile Ala 
                245                 250                 255     


Met Arg Ala Leu Xaa Asn Tyr Gln Arg Leu Cys Glu Ala Phe Asp Ala 
            260                 265                 270         


Gln Val Arg Lys Asp Ile Gln Gly Xaa Gln Gly Ala Arg Ala Ile Trp 
        275                 280                 285             


Gln Ala Leu Ser His Ala Phe Gly Arg Arg Leu Val Leu Ser Ser Xaa 
    290                 295                 300                 


Phe Arg Ile Leu Ala Asp Leu Leu Gly Phe Ala Gly Pro Leu Cys Ile 
305                 310                 315                 320 


Phe Gly Ile Val Asp His Leu Gly Lys Glu Asn Asp Val Phe Gln Pro 
                325                 330                 335     


Lys Xaa Gln Phe Leu Gly Val Tyr Phe Val Ser Ser Gln Glu Phe Leu 
            340                 345                 350         


Ala Asn Ala Tyr Val Leu Ala Val Leu Leu Phe Leu Ala Leu Leu Leu 
        355                 360                 365             


Gln Arg Xaa Phe Leu Gln Ala Ser Tyr Tyr Val Ala Ile Glu Xaa Gly 
    370                 375                 380                 


Ile Asn Leu Arg Gly Ala Ile Gln Xaa Lys Ile Tyr Asn Lys Ile Met 
385                 390                 395                 400 


His Leu Ser Xaa Ser Asn Leu Ser Met Gly Glu Met Xaa Ala Gly Gln 
                405                 410                 415     


Ile Cys Asn Leu Val Ala Ile Asp Xaa Asn Gln Leu Met Trp Phe Phe 
            420                 425                 430         


Phe Leu Cys Pro Asn Leu Trp Ala Met Pro Val Gln Ile Ile Val Gly 
        435                 440                 445             


Val Ile Leu Leu Tyr Tyr Ile Leu Gly Val Ser Ala Leu Ile Gly Ala 
    450                 455                 460                 


Ala Val Ile Ile Leu Leu Ala Pro Val Gln Tyr Phe Val Ala Xaa Lys 
465                 470                 475                 480 


Leu Ser Gln Ala Gln Arg Ser Xaa Leu Glu Tyr Ser Asn Glu Arg Leu 
                485                 490                 495     


Lys Gln Xaa Asn Glu Met Leu Arg Gly Ile Lys Leu Leu Lys Leu Tyr 
            500                 505                 510         


Ala Trp Glu Asn Ile Phe Arg Xaa Arg Val Glu Xaa Xaa Arg Arg Lys 
        515                 520                 525             


Glu Met Xaa Ser Leu Arg Ala Phe Ala Ile Tyr Xaa Ser Ile Ser Ile 
    530                 535                 540                 


Phe Met Asn Xaa Ala Ile Pro Ile Ala Ala Val Leu Ile Xaa Phe Val 
545                 550                 555                 560 


Gly His Val Ser Phe Phe Lys Glu Ala Asp Phe Ser Pro Ser Val Ala 
                565                 570                 575     


Phe Ala Ser Leu Ser Leu Phe His Ile Leu Val Xaa Pro Leu Phe Leu 
            580                 585                 590         


Leu Ser Ser Val Val Arg Ser Xaa Val Lys Ala Leu Val Ser Val Gln 
        595                 600                 605             


Lys Leu Ser Glu Phe Leu Ser Ser Ala Glu Ile Arg Glu Glu Gln Cys 
    610                 615                 620                 


Ala Pro His Glu Pro Xaa Pro Gln Gly Pro Ala Ser Lys Tyr Gln Ala 
625                 630                 635                 640 


Val Pro Leu Arg Val Val Asn Arg Lys Arg Pro Ala Arg Glu Asp Cys 
                645                 650                 655     


Arg Gly Leu Xaa Gly Pro Leu Gln Ser Leu Val Pro Ser Ala Asp Gly 
            660                 665                 670         


Asp Ala Asp Asn Cys Cys Val Gln Ile Met Gly Gly Tyr Phe Xaa Trp 
        675                 680                 685             


Xaa Pro Asp Gly Ile Pro Xaa Leu Ser Asn Ile Xaa Ile Arg Ile Pro 
    690                 695                 700                 


Arg Gly Gln Leu Xaa Met Ile Val Gly Gln Val Gly Cys Gly Lys Ser 
705                 710                 715                 720 


Ser Leu Leu Leu Ala Ala Leu Gly Glu Met Gln Lys Val Ser Gly Ala 
                725                 730                 735     


Val Phe Trp Ser Ser Leu Pro Asp Ser Glu Ile Gly Glu Asp Pro Ser 
            740                 745                 750         


Pro Glu Arg Glu Xaa Ala Xaa Asp Leu Asp Ile Arg Lys Arg Gly Pro 
        755                 760                 765             


Val Ala Tyr Ala Ser Gln Lys Pro Trp Leu Leu Asn Ala Xaa Val Glu 
    770                 775                 780                 


Glu Asn Ile Ile Phe Glu Ser Pro Phe Asn Lys Gln Arg Tyr Lys Met 
785                 790                 795                 800 


Val Ile Glu Ala Cys Ser Leu Gln Pro Asp Ile Asp Ile Leu Pro His 
                805                 810                 815     


Gly Asp Gln Xaa Gln Ile Gly Glu Arg Gly Ile Asn Leu Ser Gly Gly 
            820                 825                 830         


Gln Arg Gln Arg Ile Ser Val Ala Arg Ala Leu Tyr Gln His Ala Asn 
        835                 840                 845             


Val Val Phe Leu Asp Asp Pro Phe Ser Ala Leu Asp Ile His Leu Ser 
    850                 855                 860                 


Asp His Leu Met Gln Ala Gly Ile Leu Glu Leu Leu Arg Asp Asp Lys 
865                 870                 875                 880 


Arg Xaa Val Val Leu Val Xaa His Lys Leu Gln Tyr Leu Pro His Ala 
                885                 890                 895     


Asp Trp Ile Ile Ala Met Lys Asp Gly Xaa Ile Gln Arg Glu Gly Xaa 
            900                 905                 910         


Leu Lys Asp Phe Gln Arg Ser Glu Cys Gln Leu Phe Glu His Trp Lys 
        915                 920                 925             


Xaa Leu Met Asn Arg Gln Asp Gln Glu Leu Glu Lys Glu Xaa Val Xaa 
    930                 935                 940                 


Glu Arg Lys Ala Xaa Glu Pro Pro Gln Gly Leu Ser Arg Ala Met Ser 
945                 950                 955                 960 


Ser Arg Asp Gly Leu Leu Gln Asp Glu Glu Glu Glu Glu Glu Glu Ala 
                965                 970                 975     


Ala Glu Ser Glu Glu Asp Asp Asn Leu Ser Ser Met Leu His Gln Arg 
            980                 985                 990         


Ala Glu Ile Pro Trp Arg Ala Cys  Ala Lys Tyr Leu Ser  Ser Ala Gly 
        995                 1000                 1005             


Ile Leu  Leu Leu Ser Leu Leu  Val Phe Ser Gln Leu  Leu Lys His 
    1010                 1015                 1020             


Met Val  Leu Val Ala Ile Asp  Tyr Trp Leu Ala Lys  Trp Xaa Asp 
    1025                 1030                 1035             


Ser Ala  Leu Xaa Leu Xaa Pro  Ala Ala Arg Asn Cys  Ser Leu Ser 
    1040                 1045                 1050             


Gln Glu  Cys Xaa Leu Asp Gln  Xaa Val Tyr Ala Met  Val Phe Xaa 
    1055                 1060                 1065             


Val Leu  Cys Ser Leu Gly Ile  Val Leu Cys Leu Val  Xaa Ser Val 
    1070                 1075                 1080             


Xaa Val  Glu Trp Xaa Gly Leu  Lys Val Ala Lys Arg  Leu His Arg 
    1085                 1090                 1095             


Ser Leu  Leu Asn Arg Ile Ile  Leu Ala Pro Met Arg  Phe Phe Glu 
    1100                 1105                 1110             


Xaa Xaa  Pro Leu Gly Ser Ile  Leu Asn Arg Phe Ser  Ser Asp Cys 
    1115                 1120                 1125             


Asn Xaa  Ile Asp Gln His Ile  Pro Ser Xaa Leu Glu  Cys Leu Ser 
    1130                 1135                 1140             


Arg Ser  Xaa Leu Leu Cys Val  Ser Ala Leu Ala Val  Ile Ser Tyr 
    1145                 1150                 1155             


Val Xaa  Pro Val Phe Leu Val  Ala Leu Leu Pro Leu  Ala Ile Val 
    1160                 1165                 1170             


Cys Tyr  Phe Ile Gln Lys Tyr  Phe Arg Val Ala Ser  Arg Asp Leu 
    1175                 1180                 1185             


Gln Gln  Leu Asp Asp Xaa Xaa  Gln Leu Pro Leu Leu  Ser His Phe 
    1190                 1195                 1200             


Ala Glu  Xaa Val Glu Gly Leu  Xaa Xaa Ile Arg Ala  Phe Arg Tyr 
    1205                 1210                 1215             


Glu Ala  Arg Phe Gln Gln Lys  Leu Leu Glu Tyr Xaa  Asp Ser Asn 
    1220                 1225                 1230             


Asn Ile  Ala Ser Leu Phe Leu  Xaa Ala Ala Asn Arg  Trp Leu Glu 
    1235                 1240                 1245             


Val Arg  Met Glu Tyr Ile Gly  Ala Cys Val Val Leu  Ile Ala Ala 
    1250                 1255                 1260             


Val Xaa  Ser Ile Ser Asn Ser  Leu His Arg Glu Leu  Ser Ala Gly 
    1265                 1270                 1275             


Leu Val  Gly Leu Gly Leu Xaa  Tyr Ala Leu Met Val  Ser Asn Tyr 
    1280                 1285                 1290             


Leu Asn  Trp Met Val Arg Asn  Leu Ala Asp Met Glu  Leu Gln Leu 
    1295                 1300                 1305             


Gly Ala  Val Lys Arg Ile His  Gly Leu Leu Lys Xaa  Glu Ala Glu 
    1310                 1315                 1320             


Ser Tyr  Glu Gly Leu Leu Ala  Pro Ser Leu Ile Pro  Lys Asn Trp 
    1325                 1330                 1335             


Pro Asp  Gln Gly Lys Ile Gln  Ile Gln Asn Leu Ser  Val Arg Tyr 
    1340                 1345                 1350             


Asp Ser  Ser Leu Lys Pro Val  Leu Lys His Val Asn  Ala Leu Ile 
    1355                 1360                 1365             


Ala Pro  Gly Gln Lys Ile Gly  Ile Cys Gly Arg Xaa  Gly Ser Gly 
    1370                 1375                 1380             


Lys Ser  Ser Phe Ser Leu Ala  Phe Phe Arg Met Val  Asp Xaa Phe 
    1385                 1390                 1395             


Glu Gly  His Ile Ile Ile Asp  Gly Ile Asp Ile Ala  Lys Leu Pro 
    1400                 1405                 1410             


Leu His  Xaa Leu Arg Ser Arg  Leu Ser Ile Ile Leu  Gln Asp Pro 
    1415                 1420                 1425             


Val Leu  Phe Ser Gly Xaa Ile  Arg Phe Asn Leu Asp  Pro Glu Arg 
    1430                 1435                 1440             


Lys Cys  Ser Asp Ser Xaa Leu  Trp Glu Ala Leu Glu  Ile Ala Gln 
    1445                 1450                 1455             


Leu Lys  Leu Val Val Lys Ala  Leu Pro Gly Gly Leu  Asp Ala Ile 
    1460                 1465                 1470             


Ile Xaa  Glu Gly Gly Glu Asn  Phe Ser Gln Gly Gln  Arg Gln Leu 
    1475                 1480                 1485             


Phe Cys  Leu Ala Arg Ala Phe  Val Arg Lys Xaa Ser  Ile Phe Ile 
    1490                 1495                 1500             


Met Asp  Glu Ala Xaa Ala Ser  Ile Asp Met Ala Xaa  Glu Asn Ile 
    1505                 1510                 1515             


Leu Gln  Lys Val Val Met Xaa  Ala Phe Ala Asp Arg  Xaa Val Val 
    1520                 1525                 1530             


Xaa Ile  Ala His Arg Val His  Xaa Ile Leu Ser Ala  Asp Leu Val 
    1535                 1540                 1545             


Ile Val  Leu Lys Arg Gly Ala  Ile Leu Glu Phe Asp  Lys Pro Glu 
    1550                 1555                 1560             


Lys Leu  Leu Ser Arg Lys Asp  Ser Val Phe Ala Ser  Phe Val Arg 
    1565                 1570                 1575             


Ala Asp  Lys 
    1580     


<210> 1263
<211> 1582
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1058)..(1058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1131)..(1131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1161)..(1161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1195)..(1196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1321)..(1321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1398)..(1398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1417)..(1417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1435)..(1435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1476)..(1476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1500)..(1500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1509)..(1509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1516)..(1516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1526)..(1526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1532)..(1532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1535)..(1535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<400> 1263
Met Pro Leu Ala Phe Cys Gly Ser Glu Asn His Ser Ala Ala Tyr Arg 
1               5                   10                  15      


Val Asp Gln Gly Val Leu Asn Asn Gly Cys Phe Val Asp Ala Leu Asn 
            20                  25                  30          


Val Val Pro His Val Phe Leu Leu Phe Ile Xaa Phe Pro Ile Leu Phe 
        35                  40                  45              


Ile Gly Trp Gly Ser Gln Ser Ser Lys Val His Ile His His Ser Xaa 
    50                  55                  60                  


Trp Leu His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Xaa Phe Met 
65                  70                  75                  80  


Leu Leu Phe Val Leu Val Cys Glu Ile Ala Glu Gly Ile Leu Ser Asp 
                85                  90                  95      


Gly Val Xaa Glu Ser His His Leu His Leu Tyr Met Pro Ala Gly Met 
            100                 105                 110         


Ala Phe Met Ala Ala Val Xaa Ser Val Val Tyr Tyr His Asn Ile Glu 
        115                 120                 125             


Xaa Ser Asn Phe Pro Lys Leu Leu Ile Ala Leu Leu Val Tyr Trp Xaa 
    130                 135                 140                 


Leu Ala Phe Ile Xaa Lys Xaa Ile Lys Phe Val Lys Phe Leu Asp His 
145                 150                 155                 160 


Ala Ile Gly Phe Ser Gln Leu Arg Phe Cys Leu Xaa Gly Leu Leu Val 
                165                 170                 175     


Ile Leu Tyr Gly Met Leu Leu Leu Val Glu Val Asn Val Ile Arg Val 
            180                 185                 190         


Arg Arg Tyr Ile Phe Phe Lys Xaa Pro Arg Glu Val Lys Pro Pro Glu 
        195                 200                 205             


Asp Leu Gln Asp Leu Gly Val Arg Phe Leu Gln Pro Phe Val Asn Leu 
    210                 215                 220                 


Leu Ser Lys Gly Xaa Tyr Trp Trp Met Asn Ala Phe Ile Lys Xaa Ala 
225                 230                 235                 240 


His Lys Lys Pro Ile Asp Leu Arg Ala Ile Gly Lys Leu Pro Ile Ala 
                245                 250                 255     


Met Arg Ala Leu Xaa Asn Tyr Gln Arg Leu Cys Glu Ala Phe Asp Ala 
            260                 265                 270         


Gln Val Arg Lys Asp Ile Gln Gly Xaa Gln Gly Ala Arg Ala Ile Trp 
        275                 280                 285             


Gln Ala Leu Ser His Ala Phe Gly Arg Arg Leu Val Leu Ser Ser Xaa 
    290                 295                 300                 


Phe Arg Ile Leu Ala Asp Leu Leu Gly Phe Ala Gly Pro Leu Cys Ile 
305                 310                 315                 320 


Phe Gly Ile Val Asp His Leu Gly Lys Glu Asn Asp Val Phe Gln Pro 
                325                 330                 335     


Lys Xaa Gln Phe Leu Gly Val Tyr Phe Val Ser Ser Gln Glu Phe Leu 
            340                 345                 350         


Ala Asn Ala Tyr Val Leu Ala Val Leu Leu Phe Leu Ala Leu Leu Leu 
        355                 360                 365             


Gln Arg Xaa Phe Leu Gln Ala Ser Tyr Tyr Val Ala Ile Glu Xaa Gly 
    370                 375                 380                 


Ile Asn Leu Arg Gly Ala Ile Gln Xaa Lys Ile Tyr Asn Lys Ile Met 
385                 390                 395                 400 


His Leu Ser Xaa Ser Asn Leu Ser Met Gly Glu Met Xaa Ala Gly Gln 
                405                 410                 415     


Ile Cys Asn Leu Val Ala Ile Asp Xaa Asn Gln Leu Met Trp Phe Phe 
            420                 425                 430         


Phe Leu Cys Pro Asn Leu Trp Ala Met Pro Val Gln Ile Ile Val Gly 
        435                 440                 445             


Val Ile Leu Leu Tyr Tyr Ile Leu Gly Val Ser Ala Leu Ile Gly Ala 
    450                 455                 460                 


Ala Val Ile Ile Leu Leu Ala Pro Val Gln Tyr Phe Val Ala Xaa Lys 
465                 470                 475                 480 


Leu Ser Gln Ala Gln Arg Ser Xaa Leu Glu Tyr Ser Asn Glu Arg Leu 
                485                 490                 495     


Lys Gln Xaa Asn Glu Met Leu Arg Gly Ile Lys Leu Leu Lys Leu Tyr 
            500                 505                 510         


Ala Trp Glu Asn Ile Phe Arg Xaa Arg Val Glu Xaa Xaa Arg Arg Lys 
        515                 520                 525             


Glu Met Xaa Ser Leu Arg Ala Phe Ala Ile Tyr Xaa Ser Ile Ser Ile 
    530                 535                 540                 


Phe Met Asn Xaa Ala Ile Pro Ile Ala Ala Val Leu Ile Xaa Phe Val 
545                 550                 555                 560 


Gly His Val Ser Phe Phe Lys Glu Ala Asp Phe Ser Pro Ser Val Ala 
                565                 570                 575     


Phe Ala Ser Leu Ser Leu Phe His Ile Leu Val Xaa Pro Leu Phe Leu 
            580                 585                 590         


Leu Ser Ser Val Val Arg Ser Xaa Val Lys Ala Leu Val Ser Val Gln 
        595                 600                 605             


Lys Leu Ser Glu Phe Leu Ser Ser Ala Glu Ile Arg Glu Glu Gln Cys 
    610                 615                 620                 


Ala Pro His Glu Pro Xaa Pro Gln Gly Pro Ala Ser Lys Tyr Gln Ala 
625                 630                 635                 640 


Val Pro Leu Arg Val Val Asn Arg Lys Arg Pro Ala Arg Glu Asp Cys 
                645                 650                 655     


Arg Gly Leu Xaa Gly Pro Leu Gln Ser Leu Val Pro Ser Ala Asp Gly 
            660                 665                 670         


Asp Ala Asp Asn Cys Cys Val Gln Ile Met Gly Gly Tyr Phe Xaa Trp 
        675                 680                 685             


Xaa Pro Asp Gly Ile Pro Xaa Leu Ser Asn Ile Xaa Ile Arg Ile Pro 
    690                 695                 700                 


Arg Gly Gln Leu Xaa Met Ile Val Gly Gln Val Gly Cys Gly Lys Ser 
705                 710                 715                 720 


Ser Leu Leu Leu Ala Ala Leu Gly Glu Met Gln Lys Val Ser Gly Ala 
                725                 730                 735     


Val Phe Trp Ser Ser Ser Leu Pro Asp Ser Glu Ile Gly Glu Asp Pro 
            740                 745                 750         


Ser Pro Glu Arg Glu Xaa Ala Xaa Asp Leu Asp Ile Arg Lys Arg Gly 
        755                 760                 765             


Pro Val Ala Tyr Ala Ser Gln Lys Pro Trp Leu Leu Asn Ala Xaa Val 
    770                 775                 780                 


Glu Glu Asn Ile Ile Phe Glu Ser Pro Phe Asn Lys Gln Arg Tyr Lys 
785                 790                 795                 800 


Met Val Ile Glu Ala Cys Ser Leu Gln Pro Asp Ile Asp Ile Leu Pro 
                805                 810                 815     


His Gly Asp Gln Xaa Gln Ile Gly Glu Arg Gly Ile Asn Leu Ser Gly 
            820                 825                 830         


Gly Gln Arg Gln Arg Ile Ser Val Ala Arg Ala Leu Tyr Gln His Ala 
        835                 840                 845             


Asn Val Val Phe Leu Asp Asp Pro Phe Ser Ala Leu Asp Ile His Leu 
    850                 855                 860                 


Ser Asp His Leu Met Gln Ala Gly Ile Leu Glu Leu Leu Arg Asp Asp 
865                 870                 875                 880 


Lys Arg Xaa Val Val Leu Val Xaa His Lys Leu Gln Tyr Leu Pro His 
                885                 890                 895     


Ala Asp Trp Ile Ile Ala Met Lys Asp Gly Xaa Ile Gln Arg Glu Gly 
            900                 905                 910         


Xaa Leu Lys Asp Phe Gln Arg Ser Glu Cys Gln Leu Phe Glu His Trp 
        915                 920                 925             


Lys Xaa Leu Met Asn Arg Gln Asp Gln Glu Leu Glu Lys Glu Xaa Val 
    930                 935                 940                 


Xaa Glu Arg Lys Ala Xaa Glu Pro Pro Gln Gly Leu Ser Arg Ala Met 
945                 950                 955                 960 


Ser Ser Arg Asp Gly Leu Leu Gln Asp Glu Glu Glu Glu Glu Glu Glu 
                965                 970                 975     


Ala Ala Glu Ser Glu Glu Asp Asp Asn Leu Ser Ser Met Leu His Gln 
            980                 985                 990         


Arg Ala Glu Ile Pro Trp Arg Ala  Cys Ala Lys Tyr Leu  Ser Ser Ala 
        995                 1000                 1005             


Gly Ile  Leu Leu Leu Ser Leu  Leu Val Phe Ser Gln  Leu Leu Lys 
    1010                 1015                 1020             


His Met  Val Leu Val Ala Ile  Asp Tyr Trp Leu Ala  Lys Trp Xaa 
    1025                 1030                 1035             


Asp Ser  Ala Leu Xaa Leu Xaa  Pro Ala Ala Arg Asn  Cys Ser Leu 
    1040                 1045                 1050             


Ser Gln  Glu Cys Xaa Leu Asp  Gln Xaa Val Tyr Ala  Met Val Phe 
    1055                 1060                 1065             


Xaa Val  Leu Cys Ser Leu Gly  Ile Val Leu Cys Leu  Val Xaa Ser 
    1070                 1075                 1080             


Val Xaa  Val Glu Trp Xaa Gly  Leu Lys Val Ala Lys  Arg Leu His 
    1085                 1090                 1095             


Arg Ser  Leu Leu Asn Arg Ile  Ile Leu Ala Pro Met  Arg Phe Phe 
    1100                 1105                 1110             


Glu Xaa  Xaa Pro Leu Gly Ser  Ile Leu Asn Arg Phe  Ser Ser Asp 
    1115                 1120                 1125             


Cys Asn  Xaa Ile Asp Gln His  Ile Pro Ser Xaa Leu  Glu Cys Leu 
    1130                 1135                 1140             


Ser Arg  Ser Xaa Leu Leu Cys  Val Ser Ala Leu Ala  Val Ile Ser 
    1145                 1150                 1155             


Tyr Val  Xaa Pro Val Phe Leu  Val Ala Leu Leu Pro  Leu Ala Ile 
    1160                 1165                 1170             


Val Cys  Tyr Phe Ile Gln Lys  Tyr Phe Arg Val Ala  Ser Arg Asp 
    1175                 1180                 1185             


Leu Gln  Gln Leu Asp Asp Xaa  Xaa Gln Leu Pro Leu  Leu Ser His 
    1190                 1195                 1200             


Phe Ala  Glu Xaa Val Glu Gly  Leu Xaa Xaa Ile Arg  Ala Phe Arg 
    1205                 1210                 1215             


Tyr Glu  Ala Arg Phe Gln Gln  Lys Leu Leu Glu Tyr  Xaa Asp Ser 
    1220                 1225                 1230             


Asn Asn  Ile Ala Ser Leu Phe  Leu Xaa Ala Ala Asn  Arg Trp Leu 
    1235                 1240                 1245             


Glu Val  Arg Met Glu Tyr Ile  Gly Ala Cys Val Val  Leu Ile Ala 
    1250                 1255                 1260             


Ala Val  Xaa Ser Ile Ser Asn  Ser Leu His Arg Glu  Leu Ser Ala 
    1265                 1270                 1275             


Gly Leu  Val Gly Leu Gly Leu  Xaa Tyr Ala Leu Met  Val Ser Asn 
    1280                 1285                 1290             


Tyr Leu  Asn Trp Met Val Arg  Asn Leu Ala Asp Met  Glu Leu Gln 
    1295                 1300                 1305             


Leu Gly  Ala Val Lys Arg Ile  His Gly Leu Leu Lys  Xaa Glu Ala 
    1310                 1315                 1320             


Glu Ser  Tyr Glu Gly Leu Leu  Ala Pro Ser Leu Ile  Pro Lys Asn 
    1325                 1330                 1335             


Trp Pro  Asp Gln Gly Lys Ile  Gln Ile Gln Asn Leu  Ser Val Arg 
    1340                 1345                 1350             


Tyr Asp  Ser Ser Leu Lys Pro  Val Leu Lys His Val  Asn Ala Leu 
    1355                 1360                 1365             


Ile Ala  Pro Gly Gln Lys Ile  Gly Ile Cys Gly Arg  Xaa Gly Ser 
    1370                 1375                 1380             


Gly Lys  Ser Ser Phe Ser Leu  Ala Phe Phe Arg Met  Val Asp Xaa 
    1385                 1390                 1395             


Phe Glu  Gly His Ile Ile Ile  Asp Gly Ile Asp Ile  Ala Lys Leu 
    1400                 1405                 1410             


Pro Leu  His Xaa Leu Arg Ser  Arg Leu Ser Ile Ile  Leu Gln Asp 
    1415                 1420                 1425             


Pro Val  Leu Phe Ser Gly Xaa  Ile Arg Phe Asn Leu  Asp Pro Glu 
    1430                 1435                 1440             


Arg Lys  Cys Ser Asp Ser Xaa  Leu Trp Glu Ala Leu  Glu Ile Ala 
    1445                 1450                 1455             


Gln Leu  Lys Leu Val Val Lys  Ala Leu Pro Gly Gly  Leu Asp Ala 
    1460                 1465                 1470             


Ile Ile  Xaa Glu Gly Gly Glu  Asn Phe Ser Gln Gly  Gln Arg Gln 
    1475                 1480                 1485             


Leu Phe  Cys Leu Ala Arg Ala  Phe Val Arg Lys Xaa  Ser Ile Phe 
    1490                 1495                 1500             


Ile Met  Asp Glu Ala Xaa Ala  Ser Ile Asp Met Ala  Xaa Glu Asn 
    1505                 1510                 1515             


Ile Leu  Gln Lys Val Val Met  Xaa Ala Phe Ala Asp  Arg Xaa Val 
    1520                 1525                 1530             


Val Xaa  Ile Ala His Arg Val  His Xaa Ile Leu Ser  Ala Asp Leu 
    1535                 1540                 1545             


Val Ile  Val Leu Lys Arg Gly  Ala Ile Leu Glu Phe  Asp Lys Pro 
    1550                 1555                 1560             


Glu Lys  Leu Leu Ser Arg Lys  Asp Ser Val Phe Ala  Ser Phe Val 
    1565                 1570                 1575             


Arg Ala  Asp Lys 
    1580         


<210> 1264
<211> 62
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<400> 1264
Xaa Leu Pro Ser Ser Ala Trp Trp Xaa Arg Ser Lys Gly Xaa Ser Ser 
1               5                   10                  15      


Leu Met Ala Leu Xaa Ser Pro Asn Cys Arg Cys Xaa Pro Cys Ala His 
            20                  25                  30          


Ala Ser Pro Ser Ser Cys Arg Xaa Pro Ser Ser Ser Ala Ala Pro Ser 
        35                  40                  45              


Gly Pro Gly Ser Leu Trp Lys Gly Ile Pro His Pro Trp Val 
    50                  55                  60          


<210> 1265
<211> 53
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<400> 1265
Xaa Pro Ser Gly Pro Ser Gly Met Arg Pro Gly Ser Ser Arg Ser Phe 
1               5                   10                  15      


Ser Asn Xaa Gln Xaa Pro Xaa Xaa Leu Leu Pro Ser Ser Ser Gln Leu 
            20                  25                  30          


Pro Xaa Asp Gly Trp Lys Ser Glu Trp Ser Xaa Ser Val His Val Trp 
        35                  40                  45              


Cys Ser Ser Gln Arg 
    50              


<210> 1266
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<400> 1266
Xaa Gln Lys Tyr Phe Arg Val Ala Ser Arg Asp Leu Gln Gln Leu Asp 
1               5                   10                  15      


Asp Xaa Xaa Gln Leu Pro Leu Leu Ser His Phe Ala Glu Xaa Val Glu 
            20                  25                  30          


Gly Leu Xaa Xaa Ile Arg Ala Phe Arg Tyr Glu Ala Arg Phe Gln Gln 
        35                  40                  45              


Lys Leu Leu Glu Tyr Xaa Asp Ser Asn Asn Ile Ala Ser Leu Phe Leu 
    50                  55                  60                  


Xaa Ala Ala Asn Arg Trp Leu Glu Val Arg Met Glu Tyr Ile Gly Ala 
65                  70                  75                  80  


Cys Val Val Leu Ile Ala Ala Val Xaa Ser Ile Ser Asn Ser Leu His 
                85                  90                  95      


Arg Glu Leu Ser Ala Gly Leu Val Gly Leu Gly Leu Xaa Tyr Ala Leu 
            100                 105                 110         


Met Val Ser Asn Tyr Leu Asn Trp Met Val Arg Asn Leu Ala Asp Met 
        115                 120                 125             


Glu Leu Gln Leu Gly Ala Val Lys Arg Ile His Gly Leu Leu Lys Xaa 
    130                 135                 140                 


Glu Ala Glu Ser Tyr Glu Gly Leu Leu Ala Arg Pro Pro Ala Pro Ser 
145                 150                 155                 160 


Leu Ile Pro Lys Asn Trp Pro Asp Gln Gly Lys Ile Gln Ile Gln Asn 
                165                 170                 175     


Leu Ser Val Arg Tyr Asp Ser Ser Leu Lys Pro Val Leu Lys His Val 
            180                 185                 190         


Asn Ala Leu Ile Ala Pro Gly Gln Lys Ile Gly Ile 
        195                 200                 


<210> 1267
<211> 33
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<400> 1267
Xaa Arg Xaa Gly Ser Gly Lys Ser Ser Phe Ser Leu Ala Phe Phe Arg 
1               5                   10                  15      


Met Val Asp Xaa Phe Glu Gly Pro Arg Pro Leu Gln Arg His His Pro 
            20                  25                  30          


Ile 
    


<210> 1268
<211> 1176
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1103)..(1103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1120)..(1120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<400> 1268
Ile Ser Glu Xaa Leu Ser Ser Lys Glu Phe Leu Glu Asn Ala Tyr Val 
1               5                   10                  15      


Leu Ala Val Leu Leu Phe Leu Ala Leu Ile Leu Gln Arg Xaa Phe Leu 
            20                  25                  30          


Gln Ala Ser Tyr Tyr Val Xaa Ile Glu Xaa Gly Ile Asn Leu Arg Gly 
        35                  40                  45              


Ala Leu Leu Ala Met Ile Tyr Asn Lys Ile Leu Arg Leu Ser Xaa Ser 
    50                  55                  60                  


Asn Leu Ser Met Gly Glu Met Xaa Leu Gly Gln Ile Asn Asn Leu Val 
65                  70                  75                  80  


Ala Ile Glu Xaa Asn Gln Leu Met Trp Phe Leu Phe Leu Cys Pro Asn 
                85                  90                  95      


Leu Trp Ala Met Pro Val Gln Ile Ile Met Gly Val Ile Leu Leu Tyr 
            100                 105                 110         


Asn Leu Leu Gly Ser Ser Ala Leu Val Gly Ala Ala Val Ile Val Leu 
        115                 120                 125             


Leu Ala Pro Ile Gln Tyr Phe Ile Ala Xaa Lys Leu Ala Glu Ala Gln 
    130                 135                 140                 


Lys Ser Xaa Leu Asp Tyr Ser Xaa Glu Arg Leu Lys Lys Xaa Asn Glu 
145                 150                 155                 160 


Ile Leu Lys Gly Ile Lys Leu Leu Lys Leu Tyr Ala Trp Glu His Ile 
                165                 170                 175     


Phe Cys Lys Ser Val Glu Glu Xaa Arg Met Lys Glu Leu Ser Ser Leu 
            180                 185                 190         


Lys Xaa Phe Ala Leu Tyr Xaa Ser Leu Ser Ile Phe Met Asn Ala Ala 
        195                 200                 205             


Ile Pro Ile Ala Ala Val Leu Ala Xaa Phe Val Xaa His Ala Tyr Ala 
    210                 215                 220                 


Ser Gly Asn Asn Leu Lys Pro Ala Glu Ala Phe Ala Ser Leu Ser Leu 
225                 230                 235                 240 


Phe His Ile Leu Val Xaa Pro Leu Phe Leu Leu Ser Xaa Val Val Arg 
                245                 250                 255     


Phe Ala Val Lys Ala Ile Ile Ser Val Gln Lys Leu Asn Glu Phe Leu 
            260                 265                 270         


Leu Ser Asp Glu Ile Gly Asp Asp Ser Trp Arg Xaa Gly Glu Ser Ser 
        275                 280                 285             


Leu Pro Phe Glu Ser Cys Lys Lys His Xaa Gly Val Val Xaa Asn Gly 
    290                 295                 300                 


Tyr Phe Ser Trp Gly Ser Gly Leu Ala Xaa Leu Ser Asn Ile Asp Ile 
305                 310                 315                 320 


Arg Ile Pro Xaa Gly Gln Leu Xaa Met Ile Val Gly Gln Val Gly Cys 
                325                 330                 335     


Gly Lys Ser Ser Leu Leu Leu Ala Ile Leu Gly Glu Met Gln Xaa Leu 
            340                 345                 350         


Glu Gly Lys Val His Trp Ser Asn Val Asn Glu Ser Glu Pro Ser Phe 
        355                 360                 365             


Glu Ala Xaa Arg Ser Arg Asn Arg Tyr Ser Val Ala Tyr Ala Ala Gln 
    370                 375                 380                 


Lys Pro Trp Leu Leu Asn Ala Xaa Val Glu Glu Asn Ile Xaa Phe Gly 
385                 390                 395                 400 


Ser Pro Phe Asn Lys Gln Arg Tyr Lys Ala Val Xaa Asp Ala Cys Ser 
                405                 410                 415     


Leu Gln Pro Asp Ile Asp Leu Leu Pro Phe Gly Asp Gln Xaa Glu Ile 
            420                 425                 430         


Gly Glu Arg Gly Ile Asn Leu Ser Gly Gly Gln Arg Gln Arg Ile Cys 
        435                 440                 445             


Val Ala Arg Ala Leu Tyr Gln Asn Xaa Asn Ile Val Phe Leu Asp Asp 
    450                 455                 460                 


Pro Phe Ser Ala Leu Asp Ile His Leu Ser Asp His Leu Met Gln Glu 
465                 470                 475                 480 


Gly Ile Leu Lys Phe Leu Gln Asp Asp Lys Arg Xaa Leu Val Leu Val 
                485                 490                 495     


Xaa His Lys Leu Gln Tyr Leu Xaa His Ala Asp Trp Ile Ile Ala Met 
            500                 505                 510         


Lys Asp Gly Ser Val Leu Arg Glu Gly Xaa Leu Lys Asp Ile Gln Xaa 
        515                 520                 525             


Lys Asp Val Glu Leu Tyr Glu His Trp Lys Xaa Leu Met Asn Arg Gln 
    530                 535                 540                 


Asp Gln Glu Leu Glu Lys Asp Met Glu Ala Asp Gln Xaa Xaa Leu Glu 
545                 550                 555                 560 


Arg Lys Xaa Leu Arg Arg Ala Met Tyr Ser Arg Glu Ala Lys Ala Gln 
                565                 570                 575     


Met Glu Asp Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Asp 
            580                 585                 590         


Asn Met Ser Xaa Val Met Arg Leu Arg Xaa Lys Met Pro Trp Lys Xaa 
        595                 600                 605             


Cys Trp Arg Tyr Leu Xaa Ser Gly Gly Phe Phe Leu Leu Ile Leu Met 
    610                 615                 620                 


Ile Phe Ser Lys Leu Leu Lys His Ser Val Ile Val Ala Ile Asp Tyr 
625                 630                 635                 640 


Trp Leu Ala Xaa Trp Xaa Ser Glu Tyr Ser Ile Asn Asn Xaa Gly Lys 
                645                 650                 655     


Ala Asp Gln Xaa Tyr Tyr Val Ala Gly Phe Ser Ile Leu Cys Gly Ala 
            660                 665                 670         


Gly Ile Phe Leu Cys Leu Val Xaa Ser Leu Xaa Val Glu Trp Met Gly 
        675                 680                 685             


Leu Xaa Ala Ala Lys Asn Leu His His Asn Leu Leu Asn Lys Ile Ile 
    690                 695                 700                 


Leu Gly Pro Ile Arg Phe Phe Asp Xaa Xaa Pro Leu Gly Leu Ile Leu 
705                 710                 715                 720 


Asn Arg Phe Ser Ala Asp Xaa Asn Ile Ile Asp Gln His Ile Pro Pro 
                725                 730                 735     


Xaa Leu Glu Ser Leu Xaa Arg Ser Xaa Leu Leu Cys Leu Ser Ala Ile 
            740                 745                 750         


Gly Met Ile Ser Tyr Ala Xaa Pro Val Phe Leu Val Ala Leu Leu Pro 
        755                 760                 765             


Leu Gly Val Ala Phe Tyr Phe Ile Gln Lys Tyr Phe Arg Val Ala Ser 
    770                 775                 780                 


Lys Asp Leu Gln Glu Leu Asp Asp Ser Xaa Gln Leu Pro Leu Leu Cys 
785                 790                 795                 800 


His Phe Ser Glu Xaa Ala Glu Gly Leu Xaa Xaa Ile Arg Ala Phe Arg 
                805                 810                 815     


His Glu Xaa Arg Phe Lys Gln Arg Met Leu Glu Leu Xaa Asp Xaa Asn 
            820                 825                 830         


Asn Ile Ala Tyr Leu Phe Leu Ser Ala Ala Asn Arg Trp Leu Glu Val 
        835                 840                 845             


Arg Xaa Asp Tyr Leu Gly Ala Cys Ile Val Leu Xaa Ala Ser Ile Ala 
    850                 855                 860                 


Ser Ile Ser Gly Ser Ser Asn Ser Gly Leu Val Gly Leu Gly Leu Leu 
865                 870                 875                 880 


Tyr Ala Leu Xaa Ile Xaa Asn Tyr Leu Asn Trp Val Val Arg Asn Leu 
                885                 890                 895     


Ala Asp Leu Glu Val Gln Met Gly Ala Val Lys Lys Val Asn Ser Phe 
            900                 905                 910         


Leu Xaa Met Glu Ser Glu Asn Tyr Glu Gly Xaa Met Asp Pro Ser Gln 
        915                 920                 925             


Val Pro Glu His Trp Pro Gln Glu Gly Glu Ile Lys Ile His Asp Leu 
    930                 935                 940                 


Cys Val Arg Tyr Glu Asn Asn Leu Lys Pro Val Leu Lys His Val Lys 
945                 950                 955                 960 


Ala Tyr Ile Lys Pro Gly Gln Lys Val Gly Ile Cys Gly Arg Xaa Gly 
                965                 970                 975     


Ser Gly Lys Ser Ser Leu Ser Leu Ala Phe Phe Arg Met Val Asp Ile 
            980                 985                 990         


Phe Asp Gly Lys Ile Val Ile Asp  Gly Ile Asp Ile Ser  Lys Leu Pro 
        995                 1000                 1005             


Leu His  Xaa Leu Arg Ser Arg  Leu Ser Ile Ile Leu  Gln Asp Pro 
    1010                 1015                 1020             


Ile Leu  Phe Ser Gly Ser Ile  Arg Phe Asn Leu Asp  Pro Glu Cys 
    1025                 1030                 1035             


Lys Cys  Xaa Asp Asp Arg Leu  Trp Glu Ala Leu Glu  Ile Ala Gln 
    1040                 1045                 1050             


Leu Lys  Asn Met Val Lys Ser  Leu Pro Gly Gly Leu  Asp Ala Val 
    1055                 1060                 1065             


Val Xaa  Glu Gly Gly Glu Asn  Phe Ser Val Gly Gln  Arg Gln Leu 
    1070                 1075                 1080             


Phe Cys  Leu Ala Arg Ala Phe  Val Arg Lys Ser Ser  Ile Leu Ile 
    1085                 1090                 1095             


Met Asp  Glu Ala Xaa Ala Ser  Ile Asp Met Ala Xaa  Glu Asn Ile 
    1100                 1105                 1110             


Leu Gln  Lys Val Val Met Xaa  Ala Phe Ala Asp Arg  Xaa Val Val 
    1115                 1120                 1125             


Xaa Ile  Ala His Arg Val Ser  Ser Ile Met Asp Ala  Gly Leu Val 
    1130                 1135                 1140             


Leu Val  Phe Ser Glu Gly Ile  Leu Val Glu Cys Asp  Xaa Val Pro 
    1145                 1150                 1155             


Asn Leu  Leu Ala His Lys Asn  Gly Leu Phe Ser Xaa  Leu Val Met 
    1160                 1165                 1170             


Xaa Asn  Lys 
    1175     


<210> 1269
<211> 1549
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1017)..(1017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1287)..(1287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1296)..(1296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1384)..(1384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1443)..(1443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1476)..(1476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1493)..(1493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1499)..(1499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1502)..(1502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1509)..(1509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1512)..(1512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1529)..(1529)
<223> Selenocysteine

<400> 1269
Met Ser Leu Ser Phe Cys Gly Asn Asn Ile Ser Ser Tyr Asn Ile Asn 
1               5                   10                  15      


Asp Gly Val Leu Gln Asn Ser Cys Phe Val Asp Ala Leu Asn Leu Val 
            20                  25                  30          


Pro His Val Phe Leu Leu Phe Ile Xaa Phe Pro Ile Leu Phe Ile Gly 
        35                  40                  45              


Trp Gly Ser Gln Ser Ser Lys Val Gln Ile His His Asn Xaa Trp Leu 
    50                  55                  60                  


His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Xaa Phe Ala Leu Leu 
65                  70                  75                  80  


Phe Val His Val Cys Glu Ile Ala Glu Gly Ile Val Ser Asp Ser Arg 
                85                  90                  95      


Arg Glu Ser Arg His Leu His Leu Phe Met Pro Ala Val Met Gly Phe 
            100                 105                 110         


Val Ala Xaa Xaa Xaa Ser Ile Val Tyr Tyr His Asn Ile Glu Xaa Ser 
        115                 120                 125             


Asn Phe Pro Lys Leu Leu Leu Ala Leu Phe Leu Tyr Trp Val Met Ala 
    130                 135                 140                 


Phe Ile Xaa Lys Xaa Ile Lys Leu Val Lys Tyr Cys Gln Ser Gly Leu 
145                 150                 155                 160 


Asp Ile Ser Asn Leu Arg Phe Cys Ile Xaa Gly Met Met Val Ile Leu 
                165                 170                 175     


Asn Gly Leu Leu Met Ala Val Glu Ile Asn Val Ile Arg Val Arg Arg 
            180                 185                 190         


Tyr Val Phe Phe Met Asn Pro Gln Lys Val Lys Pro Pro Glu Asp Leu 
        195                 200                 205             


Gln Asp Leu Gly Val Arg Phe Leu Gln Pro Phe Val Asn Leu Leu Ser 
    210                 215                 220                 


Lys Ala Xaa Tyr Trp Trp Met Asn Xaa Leu Ile Ile Ser Ala His Lys 
225                 230                 235                 240 


Lys Pro Ile Asp Leu Lys Ala Ile Gly Lys Leu Pro Ile Ala Met Arg 
                245                 250                 255     


Ala Val Xaa Asn Tyr Val Cys Leu Lys Asp Ala Tyr Glu Glu Gln Lys 
            260                 265                 270         


Lys Lys Val Ala Asp His Pro Asn Arg Xaa Pro Ser Ile Trp Leu Ala 
        275                 280                 285             


Met Tyr Arg Ala Phe Gly Arg Pro Ile Leu Leu Ser Ser Xaa Phe Arg 
    290                 295                 300                 


Tyr Leu Ala Asp Leu Leu Gly Phe Ala Gly Pro Leu Cys Ile Ser Gly 
305                 310                 315                 320 


Ile Val Gln Arg Val Asn Glu Xaa Gln Asn Gly Xaa Asn Asn Xaa Xaa 
                325                 330                 335     


Gly Ile Ser Glu Xaa Leu Ser Ser Lys Glu Phe Leu Glu Asn Ala Tyr 
            340                 345                 350         


Val Leu Ala Val Leu Leu Phe Leu Ala Leu Ile Leu Gln Arg Xaa Phe 
        355                 360                 365             


Leu Gln Ala Ser Tyr Tyr Val Xaa Ile Glu Xaa Gly Ile Asn Leu Arg 
    370                 375                 380                 


Gly Ala Leu Leu Ala Met Ile Tyr Asn Lys Ile Leu Arg Leu Ser Xaa 
385                 390                 395                 400 


Ser Asn Leu Ser Met Gly Glu Met Xaa Leu Gly Gln Ile Asn Asn Leu 
                405                 410                 415     


Val Ala Ile Glu Xaa Asn Gln Leu Met Trp Phe Leu Phe Leu Cys Pro 
            420                 425                 430         


Asn Leu Trp Ala Met Pro Val Gln Ile Ile Met Gly Val Ile Leu Leu 
        435                 440                 445             


Tyr Asn Leu Leu Gly Ser Ser Ala Leu Val Gly Ala Ala Val Ile Val 
    450                 455                 460                 


Leu Leu Ala Pro Ile Gln Tyr Phe Ile Ala Xaa Lys Leu Ala Glu Ala 
465                 470                 475                 480 


Gln Lys Ser Xaa Leu Asp Tyr Ser Xaa Glu Arg Leu Lys Lys Xaa Asn 
                485                 490                 495     


Glu Ile Leu Lys Gly Ile Lys Leu Leu Lys Leu Tyr Ala Trp Glu His 
            500                 505                 510         


Ile Phe Cys Lys Ser Val Glu Glu Xaa Arg Met Lys Glu Leu Ser Ser 
        515                 520                 525             


Leu Lys Xaa Phe Ala Leu Tyr Xaa Ser Leu Ser Ile Phe Met Asn Ala 
    530                 535                 540                 


Ala Ile Pro Ile Ala Ala Val Leu Ala Xaa Phe Val Xaa His Ala Tyr 
545                 550                 555                 560 


Ala Ser Gly Asn Asn Leu Lys Pro Ala Glu Ala Phe Ala Ser Leu Ser 
                565                 570                 575     


Leu Phe His Ile Leu Val Xaa Pro Leu Phe Leu Leu Ser Xaa Val Val 
            580                 585                 590         


Arg Phe Ala Val Lys Ala Ile Ile Ser Val Gln Lys Leu Asn Glu Phe 
        595                 600                 605             


Leu Leu Ser Asp Glu Ile Gly Asp Asp Ser Trp Arg Xaa Gly Glu Ser 
    610                 615                 620                 


Ser Leu Pro Phe Glu Ser Cys Lys Lys His Xaa Gly Val Gln Pro Lys 
625                 630                 635                 640 


Xaa Ile Asn Arg Lys Gln Pro Gly Arg Tyr His Leu Asp Ser Tyr Glu 
                645                 650                 655     


Gln Ser Xaa Arg Arg Leu Arg Pro Ala Glu Xaa Glu Asp Ile Ala Ile 
            660                 665                 670         


Lys Val Xaa Asn Gly Tyr Phe Ser Trp Gly Ser Gly Leu Ala Xaa Leu 
        675                 680                 685             


Ser Asn Ile Asp Ile Arg Ile Pro Xaa Gly Gln Leu Xaa Met Ile Val 
    690                 695                 700                 


Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu Leu Ala Ile Leu Gly 
705                 710                 715                 720 


Glu Met Gln Xaa Leu Glu Gly Lys Val His Trp Ser Asn Val Asn Glu 
                725                 730                 735     


Ser Glu Pro Ser Phe Glu Ala Xaa Arg Ser Arg Asn Arg Tyr Ser Val 
            740                 745                 750         


Ala Tyr Ala Ala Gln Lys Pro Trp Leu Leu Asn Ala Xaa Val Glu Glu 
        755                 760                 765             


Asn Ile Xaa Phe Gly Ser Pro Phe Asn Lys Gln Arg Tyr Lys Ala Val 
    770                 775                 780                 


Xaa Asp Ala Cys Ser Leu Gln Pro Asp Ile Asp Leu Leu Pro Phe Gly 
785                 790                 795                 800 


Asp Gln Xaa Glu Ile Gly Glu Arg Gly Ile Asn Leu Ser Gly Gly Gln 
                805                 810                 815     


Arg Gln Arg Ile Cys Val Ala Arg Ala Leu Tyr Gln Asn Xaa Asn Ile 
            820                 825                 830         


Val Phe Leu Asp Asp Pro Phe Ser Ala Leu Asp Ile His Leu Ser Asp 
        835                 840                 845             


His Leu Met Gln Glu Gly Ile Leu Lys Phe Leu Gln Asp Asp Lys Arg 
    850                 855                 860                 


Xaa Leu Val Leu Val Xaa His Lys Leu Gln Tyr Leu Xaa His Ala Asp 
865                 870                 875                 880 


Trp Ile Ile Ala Met Lys Asp Gly Ser Val Leu Arg Glu Gly Xaa Leu 
                885                 890                 895     


Lys Asp Ile Gln Xaa Lys Asp Val Glu Leu Tyr Glu His Trp Lys Xaa 
            900                 905                 910         


Leu Met Asn Arg Gln Asp Gln Glu Leu Glu Lys Asp Met Glu Ala Asp 
        915                 920                 925             


Gln Xaa Xaa Leu Glu Arg Lys Xaa Leu Arg Arg Ala Met Tyr Ser Arg 
    930                 935                 940                 


Glu Ala Lys Ala Gln Met Glu Asp Glu Asp Glu Glu Glu Glu Glu Glu 
945                 950                 955                 960 


Glu Asp Glu Asp Asp Asn Met Ser Xaa Val Met Arg Leu Arg Xaa Lys 
                965                 970                 975     


Met Pro Trp Lys Xaa Cys Trp Arg Tyr Leu Xaa Ser Gly Gly Phe Phe 
            980                 985                 990         


Leu Leu Ile Leu Met Ile Phe Ser  Lys Leu Leu Lys His  Ser Val Ile 
        995                 1000                 1005             


Val Ala  Ile Asp Tyr Trp Leu  Ala Xaa Trp Xaa Ser  Glu Tyr Ser 
    1010                 1015                 1020             


Ile Asn  Asn Xaa Gly Lys Ala  Asp Gln Xaa Tyr Tyr  Val Ala Gly 
    1025                 1030                 1035             


Phe Ser  Ile Leu Cys Gly Ala  Gly Ile Phe Leu Cys  Leu Val Xaa 
    1040                 1045                 1050             


Ser Leu  Xaa Val Glu Trp Met  Gly Leu Xaa Ala Ala  Lys Asn Leu 
    1055                 1060                 1065             


His His  Asn Leu Leu Asn Lys  Ile Ile Leu Gly Pro  Ile Arg Phe 
    1070                 1075                 1080             


Phe Asp  Xaa Xaa Pro Leu Gly  Leu Ile Leu Asn Arg  Phe Ser Ala 
    1085                 1090                 1095             


Asp Xaa  Asn Ile Ile Asp Gln  His Ile Pro Pro Xaa  Leu Glu Ser 
    1100                 1105                 1110             


Leu Xaa  Arg Ser Xaa Leu Leu  Cys Leu Ser Ala Ile  Gly Met Ile 
    1115                 1120                 1125             


Ser Tyr  Ala Xaa Pro Val Phe  Leu Val Ala Leu Leu  Pro Leu Gly 
    1130                 1135                 1140             


Val Ala  Phe Tyr Phe Ile Gln  Lys Tyr Phe Arg Val  Ala Ser Lys 
    1145                 1150                 1155             


Asp Leu  Gln Glu Leu Asp Asp  Ser Xaa Gln Leu Pro  Leu Leu Cys 
    1160                 1165                 1170             


His Phe  Ser Glu Xaa Ala Glu  Gly Leu Xaa Xaa Ile  Arg Ala Phe 
    1175                 1180                 1185             


Arg His  Glu Xaa Arg Phe Lys  Gln Arg Met Leu Glu  Leu Xaa Asp 
    1190                 1195                 1200             


Xaa Asn  Asn Ile Ala Tyr Leu  Phe Leu Ser Ala Ala  Asn Arg Trp 
    1205                 1210                 1215             


Leu Glu  Val Arg Xaa Asp Tyr  Leu Gly Ala Cys Ile  Val Leu Xaa 
    1220                 1225                 1230             


Ala Ser  Ile Ala Ser Ile Ser  Gly Ser Ser Asn Ser  Gly Leu Val 
    1235                 1240                 1245             


Gly Leu  Gly Leu Leu Tyr Ala  Leu Xaa Ile Xaa Asn  Tyr Leu Asn 
    1250                 1255                 1260             


Trp Val  Val Arg Asn Leu Ala  Asp Leu Glu Val Gln  Met Gly Ala 
    1265                 1270                 1275             


Val Lys  Lys Val Asn Ser Phe  Leu Xaa Met Glu Ser  Glu Asn Tyr 
    1280                 1285                 1290             


Glu Gly  Xaa Met Asp Pro Ser  Gln Val Pro Glu His  Trp Pro Gln 
    1295                 1300                 1305             


Glu Gly  Glu Ile Lys Ile His  Asp Leu Cys Val Arg  Tyr Glu Asn 
    1310                 1315                 1320             


Asn Leu  Lys Pro Val Leu Lys  His Val Lys Ala Tyr  Ile Lys Pro 
    1325                 1330                 1335             


Gly Gln  Lys Val Gly Ile Cys  Gly Arg Xaa Gly Ser  Gly Lys Ser 
    1340                 1345                 1350             


Ser Leu  Ser Leu Ala Phe Phe  Arg Met Val Asp Ile  Phe Asp Gly 
    1355                 1360                 1365             


Lys Ile  Val Ile Asp Gly Ile  Asp Ile Ser Lys Leu  Pro Leu His 
    1370                 1375                 1380             


Xaa Leu  Arg Ser Arg Leu Ser  Ile Ile Leu Gln Asp  Pro Ile Leu 
    1385                 1390                 1395             


Phe Ser  Gly Ser Ile Arg Phe  Asn Leu Asp Pro Glu  Cys Lys Cys 
    1400                 1405                 1410             


Xaa Asp  Asp Arg Leu Trp Glu  Ala Leu Glu Ile Ala  Gln Leu Lys 
    1415                 1420                 1425             


Asn Met  Val Lys Ser Leu Pro  Gly Gly Leu Asp Ala  Val Val Xaa 
    1430                 1435                 1440             


Glu Gly  Gly Glu Asn Phe Ser  Val Gly Gln Arg Gln  Leu Phe Cys 
    1445                 1450                 1455             


Leu Ala  Arg Ala Phe Val Arg  Lys Ser Ser Ile Leu  Ile Met Asp 
    1460                 1465                 1470             


Glu Ala  Xaa Ala Ser Ile Asp  Met Ala Xaa Glu Asn  Ile Leu Gln 
    1475                 1480                 1485             


Lys Val  Val Met Xaa Ala Phe  Ala Asp Arg Xaa Val  Val Xaa Ile 
    1490                 1495                 1500             


Ala His  Arg Val His Xaa Ile  Leu Xaa Ala Asp Leu  Val Ile Val 
    1505                 1510                 1515             


Met Lys  Arg Gly Asn Ile Leu  Glu Tyr Asp Xaa Pro  Glu Ser Leu 
    1520                 1525                 1530             


Leu Ala  Gln Glu Asn Gly Val  Phe Ala Ser Phe Val  Arg Ala Asp 
    1535                 1540                 1545             


Met 
    


<210> 1270
<211> 1549
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1017)..(1017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1287)..(1287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1296)..(1296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1384)..(1384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1443)..(1443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1476)..(1476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1493)..(1493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1499)..(1499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1502)..(1502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1529)..(1529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1543)..(1543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<400> 1270
Met Ser Leu Ser Phe Cys Gly Asn Asn Ile Ser Ser Tyr Asn Ile Asn 
1               5                   10                  15      


Asp Gly Val Leu Gln Asn Ser Cys Phe Val Asp Ala Leu Asn Leu Val 
            20                  25                  30          


Pro His Val Phe Leu Leu Phe Ile Xaa Phe Pro Ile Leu Phe Ile Gly 
        35                  40                  45              


Trp Gly Ser Gln Ser Ser Lys Val Gln Ile His His Asn Xaa Trp Leu 
    50                  55                  60                  


His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Xaa Phe Ala Leu Leu 
65                  70                  75                  80  


Phe Val His Val Cys Glu Ile Ala Glu Gly Ile Val Ser Asp Ser Arg 
                85                  90                  95      


Arg Glu Ser Arg His Leu His Leu Phe Met Pro Ala Val Met Gly Phe 
            100                 105                 110         


Val Ala Xaa Xaa Xaa Ser Ile Val Tyr Tyr His Asn Ile Glu Xaa Ser 
        115                 120                 125             


Asn Phe Pro Lys Leu Leu Leu Ala Leu Phe Leu Tyr Trp Val Met Ala 
    130                 135                 140                 


Phe Ile Xaa Lys Xaa Ile Lys Leu Val Lys Tyr Cys Gln Ser Gly Leu 
145                 150                 155                 160 


Asp Ile Ser Asn Leu Arg Phe Cys Ile Xaa Gly Met Met Val Ile Leu 
                165                 170                 175     


Asn Gly Leu Leu Met Ala Val Glu Ile Asn Val Ile Arg Val Arg Arg 
            180                 185                 190         


Tyr Val Phe Phe Met Asn Pro Gln Lys Val Lys Pro Pro Glu Asp Leu 
        195                 200                 205             


Gln Asp Leu Gly Val Arg Phe Leu Gln Pro Phe Val Asn Leu Leu Ser 
    210                 215                 220                 


Lys Ala Xaa Tyr Trp Trp Met Asn Xaa Leu Ile Ile Ser Ala His Lys 
225                 230                 235                 240 


Lys Pro Ile Asp Leu Lys Ala Ile Gly Lys Leu Pro Ile Ala Met Arg 
                245                 250                 255     


Ala Val Xaa Asn Tyr Val Cys Leu Lys Asp Ala Tyr Glu Glu Gln Lys 
            260                 265                 270         


Lys Lys Val Ala Asp His Pro Asn Arg Xaa Pro Ser Ile Trp Leu Ala 
        275                 280                 285             


Met Tyr Arg Ala Phe Gly Arg Pro Ile Leu Leu Ser Ser Xaa Phe Arg 
    290                 295                 300                 


Tyr Leu Ala Asp Leu Leu Gly Phe Ala Gly Pro Leu Cys Ile Ser Gly 
305                 310                 315                 320 


Ile Val Gln Arg Val Asn Glu Xaa Gln Asn Gly Xaa Asn Asn Xaa Xaa 
                325                 330                 335     


Gly Ile Ser Glu Xaa Leu Ser Ser Lys Glu Phe Leu Glu Asn Ala Tyr 
            340                 345                 350         


Val Leu Ala Val Leu Leu Phe Leu Ala Leu Ile Leu Gln Arg Xaa Phe 
        355                 360                 365             


Leu Gln Ala Ser Tyr Tyr Val Xaa Ile Glu Xaa Gly Ile Asn Leu Arg 
    370                 375                 380                 


Gly Ala Leu Leu Ala Met Ile Tyr Asn Lys Ile Leu Arg Leu Ser Xaa 
385                 390                 395                 400 


Ser Asn Leu Ser Met Gly Glu Met Xaa Leu Gly Gln Ile Asn Asn Leu 
                405                 410                 415     


Val Ala Ile Glu Xaa Asn Gln Leu Met Trp Phe Leu Phe Leu Cys Pro 
            420                 425                 430         


Asn Leu Trp Ala Met Pro Val Gln Ile Ile Met Gly Val Ile Leu Leu 
        435                 440                 445             


Tyr Asn Leu Leu Gly Ser Ser Ala Leu Val Gly Ala Ala Val Ile Val 
    450                 455                 460                 


Leu Leu Ala Pro Ile Gln Tyr Phe Ile Ala Xaa Lys Leu Ala Glu Ala 
465                 470                 475                 480 


Gln Lys Ser Xaa Leu Asp Tyr Ser Xaa Glu Arg Leu Lys Lys Xaa Asn 
                485                 490                 495     


Glu Ile Leu Lys Gly Ile Lys Leu Leu Lys Leu Tyr Ala Trp Glu His 
            500                 505                 510         


Ile Phe Cys Lys Ser Val Glu Glu Xaa Arg Met Lys Glu Leu Ser Ser 
        515                 520                 525             


Leu Lys Xaa Phe Ala Leu Tyr Xaa Ser Leu Ser Ile Phe Met Asn Ala 
    530                 535                 540                 


Ala Ile Pro Ile Ala Ala Val Leu Ala Xaa Phe Val Xaa His Ala Tyr 
545                 550                 555                 560 


Ala Ser Gly Asn Asn Leu Lys Pro Ala Glu Ala Phe Ala Ser Leu Ser 
                565                 570                 575     


Leu Phe His Ile Leu Val Xaa Pro Leu Phe Leu Leu Ser Xaa Val Val 
            580                 585                 590         


Arg Phe Ala Val Lys Ala Ile Ile Ser Val Gln Lys Leu Asn Glu Phe 
        595                 600                 605             


Leu Leu Ser Asp Glu Ile Gly Asp Asp Ser Trp Arg Xaa Gly Glu Ser 
    610                 615                 620                 


Ser Leu Pro Phe Glu Ser Cys Lys Lys His Xaa Gly Val Gln Pro Lys 
625                 630                 635                 640 


Xaa Ile Asn Arg Lys Gln Pro Gly Arg Tyr His Leu Asp Ser Tyr Glu 
                645                 650                 655     


Gln Ser Xaa Arg Arg Leu Arg Pro Ala Glu Xaa Glu Asp Ile Ala Ile 
            660                 665                 670         


Lys Val Xaa Asn Gly Tyr Phe Ser Trp Gly Ser Gly Leu Ala Xaa Leu 
        675                 680                 685             


Ser Asn Ile Asp Ile Arg Ile Pro Xaa Gly Gln Leu Xaa Met Ile Val 
    690                 695                 700                 


Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu Leu Ala Ile Leu Gly 
705                 710                 715                 720 


Glu Met Gln Xaa Leu Glu Gly Lys Val His Trp Ser Asn Val Asn Glu 
                725                 730                 735     


Ser Glu Pro Ser Phe Glu Ala Xaa Arg Ser Arg Asn Arg Tyr Ser Val 
            740                 745                 750         


Ala Tyr Ala Ala Gln Lys Pro Trp Leu Leu Asn Ala Xaa Val Glu Glu 
        755                 760                 765             


Asn Ile Xaa Phe Gly Ser Pro Phe Asn Lys Gln Arg Tyr Lys Ala Val 
    770                 775                 780                 


Xaa Asp Ala Cys Ser Leu Gln Pro Asp Ile Asp Leu Leu Pro Phe Gly 
785                 790                 795                 800 


Asp Gln Xaa Glu Ile Gly Glu Arg Gly Ile Asn Leu Ser Gly Gly Gln 
                805                 810                 815     


Arg Gln Arg Ile Cys Val Ala Arg Ala Leu Tyr Gln Asn Xaa Asn Ile 
            820                 825                 830         


Val Phe Leu Asp Asp Pro Phe Ser Ala Leu Asp Ile His Leu Ser Asp 
        835                 840                 845             


His Leu Met Gln Glu Gly Ile Leu Lys Phe Leu Gln Asp Asp Lys Arg 
    850                 855                 860                 


Xaa Leu Val Leu Val Xaa His Lys Leu Gln Tyr Leu Xaa His Ala Asp 
865                 870                 875                 880 


Trp Ile Ile Ala Met Lys Asp Gly Ser Val Leu Arg Glu Gly Xaa Leu 
                885                 890                 895     


Lys Asp Ile Gln Xaa Lys Asp Val Glu Leu Tyr Glu His Trp Lys Xaa 
            900                 905                 910         


Leu Met Asn Arg Gln Asp Gln Glu Leu Glu Lys Asp Met Glu Ala Asp 
        915                 920                 925             


Gln Xaa Xaa Leu Glu Arg Lys Xaa Leu Arg Arg Ala Met Tyr Ser Arg 
    930                 935                 940                 


Glu Ala Lys Ala Gln Met Glu Asp Glu Asp Glu Glu Glu Glu Glu Glu 
945                 950                 955                 960 


Glu Asp Glu Asp Asp Asn Met Ser Xaa Val Met Arg Leu Arg Xaa Lys 
                965                 970                 975     


Met Pro Trp Lys Xaa Cys Trp Arg Tyr Leu Xaa Ser Gly Gly Phe Phe 
            980                 985                 990         


Leu Leu Ile Leu Met Ile Phe Ser  Lys Leu Leu Lys His  Ser Val Ile 
        995                 1000                 1005             


Val Ala  Ile Asp Tyr Trp Leu  Ala Xaa Trp Xaa Ser  Glu Tyr Ser 
    1010                 1015                 1020             


Ile Asn  Asn Xaa Gly Lys Ala  Asp Gln Xaa Tyr Tyr  Val Ala Gly 
    1025                 1030                 1035             


Phe Ser  Ile Leu Cys Gly Ala  Gly Ile Phe Leu Cys  Leu Val Xaa 
    1040                 1045                 1050             


Ser Leu  Xaa Val Glu Trp Met  Gly Leu Xaa Ala Ala  Lys Asn Leu 
    1055                 1060                 1065             


His His  Asn Leu Leu Asn Lys  Ile Ile Leu Gly Pro  Ile Arg Phe 
    1070                 1075                 1080             


Phe Asp  Xaa Xaa Pro Leu Gly  Leu Ile Leu Asn Arg  Phe Ser Ala 
    1085                 1090                 1095             


Asp Xaa  Asn Ile Ile Asp Gln  His Ile Pro Pro Xaa  Leu Glu Ser 
    1100                 1105                 1110             


Leu Xaa  Arg Ser Xaa Leu Leu  Cys Leu Ser Ala Ile  Gly Met Ile 
    1115                 1120                 1125             


Ser Tyr  Ala Xaa Pro Val Phe  Leu Val Ala Leu Leu  Pro Leu Gly 
    1130                 1135                 1140             


Val Ala  Phe Tyr Phe Ile Gln  Lys Tyr Phe Arg Val  Ala Ser Lys 
    1145                 1150                 1155             


Asp Leu  Gln Glu Leu Asp Asp  Ser Xaa Gln Leu Pro  Leu Leu Cys 
    1160                 1165                 1170             


His Phe  Ser Glu Xaa Ala Glu  Gly Leu Xaa Xaa Ile  Arg Ala Phe 
    1175                 1180                 1185             


Arg His  Glu Xaa Arg Phe Lys  Gln Arg Met Leu Glu  Leu Xaa Asp 
    1190                 1195                 1200             


Xaa Asn  Asn Ile Ala Tyr Leu  Phe Leu Ser Ala Ala  Asn Arg Trp 
    1205                 1210                 1215             


Leu Glu  Val Arg Xaa Asp Tyr  Leu Gly Ala Cys Ile  Val Leu Xaa 
    1220                 1225                 1230             


Ala Ser  Ile Ala Ser Ile Ser  Gly Ser Ser Asn Ser  Gly Leu Val 
    1235                 1240                 1245             


Gly Leu  Gly Leu Leu Tyr Ala  Leu Xaa Ile Xaa Asn  Tyr Leu Asn 
    1250                 1255                 1260             


Trp Val  Val Arg Asn Leu Ala  Asp Leu Glu Val Gln  Met Gly Ala 
    1265                 1270                 1275             


Val Lys  Lys Val Asn Ser Phe  Leu Xaa Met Glu Ser  Glu Asn Tyr 
    1280                 1285                 1290             


Glu Gly  Xaa Met Asp Pro Ser  Gln Val Pro Glu His  Trp Pro Gln 
    1295                 1300                 1305             


Glu Gly  Glu Ile Lys Ile His  Asp Leu Cys Val Arg  Tyr Glu Asn 
    1310                 1315                 1320             


Asn Leu  Lys Pro Val Leu Lys  His Val Lys Ala Tyr  Ile Lys Pro 
    1325                 1330                 1335             


Gly Gln  Lys Val Gly Ile Cys  Gly Arg Xaa Gly Ser  Gly Lys Ser 
    1340                 1345                 1350             


Ser Leu  Ser Leu Ala Phe Phe  Arg Met Val Asp Ile  Phe Asp Gly 
    1355                 1360                 1365             


Lys Ile  Val Ile Asp Gly Ile  Asp Ile Ser Lys Leu  Pro Leu His 
    1370                 1375                 1380             


Xaa Leu  Arg Ser Arg Leu Ser  Ile Ile Leu Gln Asp  Pro Ile Leu 
    1385                 1390                 1395             


Phe Ser  Gly Ser Ile Arg Phe  Asn Leu Asp Pro Glu  Cys Lys Cys 
    1400                 1405                 1410             


Xaa Asp  Asp Arg Leu Trp Glu  Ala Leu Glu Ile Ala  Gln Leu Lys 
    1415                 1420                 1425             


Asn Met  Val Lys Ser Leu Pro  Gly Gly Leu Asp Ala  Val Val Xaa 
    1430                 1435                 1440             


Glu Gly  Gly Glu Asn Phe Ser  Val Gly Gln Arg Gln  Leu Phe Cys 
    1445                 1450                 1455             


Leu Ala  Arg Ala Phe Val Arg  Lys Ser Ser Ile Leu  Ile Met Asp 
    1460                 1465                 1470             


Glu Ala  Xaa Ala Ser Ile Asp  Met Ala Xaa Glu Asn  Ile Leu Gln 
    1475                 1480                 1485             


Lys Val  Val Met Xaa Ala Phe  Ala Asp Arg Xaa Val  Val Xaa Ile 
    1490                 1495                 1500             


Ala His  Arg Val Ser Ser Ile  Met Asp Ala Gly Leu  Val Leu Val 
    1505                 1510                 1515             


Phe Ser  Glu Gly Ile Leu Val  Glu Cys Asp Xaa Val  Pro Asn Leu 
    1520                 1525                 1530             


Leu Ala  His Lys Asn Gly Leu  Phe Ser Xaa Leu Val  Met Xaa Asn 
    1535                 1540                 1545             


Lys 
    


<210> 1271
<211> 149
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 1271
Met Ser Leu Ser Phe Cys Gly Asn Asn Ile Ser Ser Tyr Asn Ile Asn 
1               5                   10                  15      


Asp Gly Val Leu Gln Asn Ser Cys Phe Val Asp Ala Leu Asn Leu Val 
            20                  25                  30          


Pro His Val Phe Leu Leu Phe Ile Xaa Phe Pro Ile Leu Phe Ile Gly 
        35                  40                  45              


Trp Gly Ser Gln Ser Ser Lys Val Gln Ile His His Asn Xaa Trp Leu 
    50                  55                  60                  


His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Xaa Phe Ala Leu Leu 
65                  70                  75                  80  


Phe Val His Val Cys Glu Ile Ala Glu Gly Ile Val Ser Asp Ser Arg 
                85                  90                  95      


Arg Glu Ser Arg His Leu His Leu Phe Met Pro Ala Val Met Gly Phe 
            100                 105                 110         


Val Ala Xaa Xaa Xaa Ser Ile Val Tyr Tyr His Asn Ile Glu Xaa Ser 
        115                 120                 125             


Asn Phe Pro Lys Leu Leu Leu Gly Phe Ser His His Glu Ser Lys Ser 
    130                 135                 140                 


Cys Tyr Gln His Ser 
145                 


<210> 1272
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 1272
Met Ser Leu Ser Phe Cys Gly Asn Asn Ile Ser Ser Tyr Asn Ile Asn 
1               5                   10                  15      


Asp Gly Val Leu Gln Asn Ser Cys Phe Val Asp Ala Leu Asn Leu Val 
            20                  25                  30          


Pro His Val Phe Leu Leu Phe Ile Xaa Phe Pro Ile Leu Phe Ile Gly 
        35                  40                  45              


Trp Gly Ser Gln Ser Ser Lys Val Gln Ile His His Asn Xaa Trp Leu 
    50                  55                  60                  


His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Xaa Phe Ala Leu Leu 
65                  70                  75                  80  


Phe Val His Val Cys Glu Ile Ala Glu Gly Ile Val Ser Asp Ser Arg 
                85                  90                  95      


Arg Glu Ser Arg His Leu His Leu Phe Met Pro Ala Val Met Gly Phe 
            100                 105                 110         


Val Ala Xaa Xaa Xaa Ser Ile Val Tyr Tyr His Asn Ile Glu Xaa Ser 
        115                 120                 125             


Asn Phe Pro Lys Leu Leu Leu Val Pro Gly Val Ser Val Ser Gly Leu 
    130                 135                 140                 


Glu Ser Lys Asp Ile Phe Pro Arg Phe Lys Pro Phe Xaa Asp Ala Val 
145                 150                 155                 160 


Gly Met Pro His Phe Xaa Arg Ile Xaa Met 
                165                 170 


<210> 1273
<211> 56
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<400> 1273
Met Asn Ala Met Leu Glu Xaa Pro Glu Leu Pro Ala Val Phe Asp Gly 
1               5                   10                  15      


Val Lys Leu Ala Ala Val Ala Ala Val Leu Tyr Val Ile Val Arg Cys 
            20                  25                  30          


Leu Asn Leu Lys Ser Pro Xaa Ala Pro Pro Asp Leu Tyr Phe Gln Asp 
        35                  40                  45              


Ser Gly Leu Ser Arg Phe Leu Leu 
    50                  55      


<210> 1274
<211> 123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 1274
Met Asn Ala Met Leu Glu Xaa Pro Glu Leu Pro Ala Val Phe Asp Gly 
1               5                   10                  15      


Val Lys Leu Ala Ala Val Ala Ala Val Leu Tyr Val Ile Val Arg Cys 
            20                  25                  30          


Leu Asn Leu Lys Ser Pro Xaa Ala Pro Pro Asp Leu Tyr Phe Gln Asp 
        35                  40                  45              


Ser Gly Leu Ser Arg Phe Leu Leu Lys Ser Cys Pro Leu Leu Xaa Lys 
    50                  55                  60                  


Glu Tyr Ile Pro Pro Leu Ile Trp Gly Lys Ser Gly His Ile Gln Xaa 
65                  70                  75                  80  


Ala Leu Tyr Gly Lys Met Gly Arg Val Arg Ser Pro His Pro Tyr Gly 
                85                  90                  95      


His Arg Lys Phe Ile Xaa Met Ser Asp Gly Ala Xaa Ser Xaa Phe Asp 
            100                 105                 110         


Leu Phe Glu Pro Leu Ala Glu His Cys Val Gly 
        115                 120             


<210> 1275
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 1275
Met Asn Ala Met Leu Glu Xaa Pro Glu Leu Pro Ala Val Phe Asp Gly 
1               5                   10                  15      


Val Lys Leu Ala Ala Val Ala Ala Val Leu Tyr Val Ile Val Arg Cys 
            20                  25                  30          


Leu Asn Leu Lys Ser Pro Xaa Ala Pro Pro Asp Leu Tyr Phe Gln Asp 
        35                  40                  45              


Ser Gly Leu Ser Arg Phe Leu Leu Lys Ser Cys Pro Leu Leu Xaa Lys 
    50                  55                  60                  


Glu Tyr Ile Pro Pro Leu Ile Trp Gly Lys Ser Gly His Ile Gln Xaa 
65                  70                  75                  80  


Ala Leu Tyr Gly Lys Met Gly Arg Val Arg Ser Pro His Pro Tyr Gly 
                85                  90                  95      


His Arg Lys Phe Ile Xaa Met Ser Asp Gly Ala Xaa Ser Xaa Phe Asp 
            100                 105                 110         


Leu Phe Glu Pro Leu Ala Glu His Cys Val Gly Asp Asp Ile Xaa Met 
        115                 120                 125             


Val Ile Cys 
    130     


<210> 1276
<211> 425
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<400> 1276
Met Asn Ala Met Leu Glu Xaa Pro Glu Leu Pro Ala Val Phe Asp Gly 
1               5                   10                  15      


Val Lys Leu Ala Ala Val Ala Ala Val Leu Tyr Val Ile Val Arg Cys 
            20                  25                  30          


Leu Asn Leu Lys Ser Pro Xaa Ala Pro Pro Asp Leu Tyr Phe Gln Asp 
        35                  40                  45              


Ser Gly Leu Ser Arg Phe Leu Leu Lys Ser Cys Pro Leu Leu Xaa Lys 
    50                  55                  60                  


Glu Tyr Ile Pro Pro Leu Ile Trp Gly Lys Ser Gly His Ile Gln Xaa 
65                  70                  75                  80  


Ala Leu Tyr Gly Lys Met Gly Arg Val Arg Ser Pro His Pro Tyr Gly 
                85                  90                  95      


His Arg Lys Phe Ile Xaa Met Ser Asp Gly Ala Xaa Ser Xaa Phe Asp 
            100                 105                 110         


Leu Phe Glu Pro Leu Ala Glu His Cys Val Gly Asp Asp Ile Xaa Met 
        115                 120                 125             


Val Ile Cys Pro Gly Ile Ala Asn His Ser Glu Lys Gln Tyr Ile Arg 
    130                 135                 140                 


Xaa Phe Val Asp Tyr Ala Gln Lys Asn Gly Tyr Arg Cys Ala Val Leu 
145                 150                 155                 160 


Asn His Leu Gly Ala Leu Pro Asn Ile Glu Leu Xaa Ser Pro Arg Met 
                165                 170                 175     


Phe Xaa Tyr Gly Cys Xaa Trp Glu Phe Gly Ala Met Val Asn Tyr Ile 
            180                 185                 190         


Lys Lys Xaa Tyr Pro Leu Xaa Gln Leu Val Val Val Gly Phe Ser Leu 
        195                 200                 205             


Gly Gly Asn Ile Val Cys Lys Tyr Leu Gly Glu Xaa Gln Ala Asn Gln 
    210                 215                 220                 


Glu Lys Val Leu Cys Cys Val Ser Val Cys Gln Gly Tyr Ser Ala Leu 
225                 230                 235                 240 


Arg Ala Gln Glu Xaa Phe Met Gln Trp Asp Gln Cys Arg Arg Phe Tyr 
                245                 250                 255     


Asn Phe Leu Met Ala Asp Asn Met Lys Lys Ile Ile Leu Ser His Arg 
            260                 265                 270         


Gln Ala Leu Phe Gly Asp His Val Lys Lys Pro Gln Ser Leu Glu Asp 
        275                 280                 285             


Xaa Asp Leu Ser Arg Leu Tyr Xaa Ala Xaa Ser Leu Met Gln Ile Asp 
    290                 295                 300                 


Asp Asn Val Met Arg Lys Phe His Gly Tyr Asn Ser Leu Lys Glu Tyr 
305                 310                 315                 320 


Tyr Glu Glu Glu Ser Cys Met Arg Tyr Leu His Arg Ile Tyr Val Pro 
                325                 330                 335     


Leu Met Leu Val Asn Ala Ala Asp Asp Pro Leu Val His Glu Ser Leu 
            340                 345                 350         


Leu Xaa Ile Pro Lys Ser Leu Ser Glu Lys Arg Glu Asn Val Met Phe 
        355                 360                 365             


Val Leu Pro Leu His Gly Gly His Leu Gly Phe Phe Glu Gly Ser Val 
    370                 375                 380                 


Leu Phe Pro Glu Pro Leu Xaa Trp Met Asp Lys Leu Val Val Glu Tyr 
385                 390                 395                 400 


Ala Asn Ala Ile Cys Gln Trp Glu Arg Asn Lys Leu Gln Cys Ser Asp 
                405                 410                 415     


Xaa Glu Gln Val Glu Ala Asp Leu Glu 
            420                 425 


<210> 1277
<211> 51
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<400> 1277
Met Asp Leu Asp Val Val Asn Met Phe Val Ile Ala Gly Gly Xaa Leu 
1               5                   10                  15      


Ala Ile Pro Ile Leu Ala Phe Val Ala Ser Phe Leu Leu Trp Pro Ser 
            20                  25                  30          


Ala Leu Ile Arg Ile Tyr Tyr Cys Met Ser Ser Val Lys Asp Val Ala 
        35                  40                  45              


Ala Leu Ser 
    50      


<210> 1278
<211> 173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<400> 1278
Met Asp Leu Asp Val Val Asn Met Phe Val Ile Ala Gly Gly Xaa Leu 
1               5                   10                  15      


Ala Ile Pro Ile Leu Ala Phe Val Ala Ser Phe Leu Leu Trp Pro Ser 
            20                  25                  30          


Ala Leu Ile Arg Ile Tyr Tyr Trp Tyr Trp Arg Arg Xaa Leu Gly Met 
        35                  40                  45              


Gln Val Arg Tyr Val His His Glu Asp Tyr Gln Phe Cys Tyr Ser Phe 
    50                  55                  60                  


Arg Gly Arg Pro Gly His Lys Pro Ser Ile Leu Met Leu His Gly Phe 
65                  70                  75                  80  


Ser Ala His Lys Asp Met Trp Leu Ser Val Val Lys Phe Leu Pro Lys 
                85                  90                  95      


Asn Leu His Leu Val Cys Val Asp Met Pro Gly His Glu Gly Xaa Xaa 
            100                 105                 110         


Arg Ser Ser Leu Asp Asp Leu Ser Ile Asp Gly Gln Val Lys Arg Ile 
        115                 120                 125             


His Gln Phe Val Glu Cys Leu Lys Leu Asn Lys Lys Pro Phe His Leu 
    130                 135                 140                 


Val Gly Xaa Ser Met Gly Gly Gln Val Ala Gly Val Tyr Ala Ala Tyr 
145                 150                 155                 160 


Tyr Pro Ser Asp Val Ser Ser Leu Cys Leu Val Cys Pro 
                165                 170             


<210> 1279
<211> 225
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<400> 1279
Met Asp Leu Asp Val Val Asn Met Phe Val Ile Ala Gly Gly Xaa Leu 
1               5                   10                  15      


Ala Ile Pro Ile Leu Ala Phe Val Ala Ser Phe Leu Leu Trp Pro Ser 
            20                  25                  30          


Ala Leu Ile Arg Ile Tyr Tyr Trp Tyr Trp Arg Arg Xaa Leu Gly Met 
        35                  40                  45              


Gln Val Arg Tyr Val His His Glu Asp Tyr Gln Phe Cys Tyr Ser Phe 
    50                  55                  60                  


Arg Gly Arg Pro Gly His Lys Pro Ser Ile Leu Met Leu His Gly Phe 
65                  70                  75                  80  


Ser Ala His Lys Asp Met Trp Leu Ser Val Val Lys Phe Leu Pro Lys 
                85                  90                  95      


Asn Leu His Leu Val Cys Val Asp Met Pro Gly His Glu Gly Xaa Xaa 
            100                 105                 110         


Arg Ser Ser Leu Asp Asp Leu Ser Ile Asp Gly Gln Val Lys Arg Ile 
        115                 120                 125             


His Gln Phe Val Glu Cys Leu Lys Leu Asn Lys Lys Pro Phe His Leu 
    130                 135                 140                 


Val Gly Xaa Ser Met Gly Gly Gln Val Ala Gly Val Tyr Ala Ala Tyr 
145                 150                 155                 160 


Tyr Pro Ser Asp Val Ser Ser Leu Cys Leu Val Cys Pro Ala Gly Leu 
                165                 170                 175     


Gln Tyr Ser Xaa Asp Asn Gln Phe Val Gln Arg Leu Lys Glu Leu Gln 
            180                 185                 190         


Gly Ser Ala Ala Val Glu Lys Ile Pro Leu Ile Pro Ser Xaa Pro Glu 
        195                 200                 205             


Glu Met Ser Glu Met Leu Gln Leu Cys Ser Tyr Val Arg Phe Lys Val 
    210                 215                 220                 


Pro 
225 


<210> 1280
<211> 337
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<400> 1280
Met Asp Leu Asp Val Val Asn Met Phe Val Ile Ala Gly Gly Xaa Leu 
1               5                   10                  15      


Ala Ile Pro Ile Leu Ala Phe Val Ala Ser Phe Leu Leu Trp Pro Ser 
            20                  25                  30          


Ala Leu Ile Arg Ile Tyr Tyr Trp Tyr Trp Arg Arg Xaa Leu Gly Met 
        35                  40                  45              


Gln Val Arg Tyr Val His His Glu Asp Tyr Gln Phe Cys Tyr Ser Phe 
    50                  55                  60                  


Arg Gly Arg Pro Gly His Lys Pro Ser Ile Leu Met Leu His Gly Phe 
65                  70                  75                  80  


Ser Ala His Lys Asp Met Trp Leu Ser Val Val Lys Phe Leu Pro Lys 
                85                  90                  95      


Asn Leu His Leu Val Cys Val Asp Met Pro Gly His Glu Gly Xaa Xaa 
            100                 105                 110         


Arg Ser Ser Leu Asp Asp Leu Ser Ile Asp Gly Gln Val Lys Arg Ile 
        115                 120                 125             


His Gln Phe Val Glu Cys Leu Lys Leu Asn Lys Lys Pro Phe His Leu 
    130                 135                 140                 


Val Gly Xaa Ser Met Gly Gly Gln Val Ala Gly Val Tyr Ala Ala Tyr 
145                 150                 155                 160 


Tyr Pro Ser Asp Val Ser Ser Leu Cys Leu Val Cys Pro Ala Gly Leu 
                165                 170                 175     


Gln Tyr Ser Xaa Asp Asn Gln Phe Val Gln Arg Leu Lys Glu Leu Gln 
            180                 185                 190         


Gly Ser Ala Ala Val Glu Lys Ile Pro Leu Ile Pro Ser Xaa Pro Glu 
        195                 200                 205             


Glu Met Ser Glu Met Leu Gln Leu Cys Ser Tyr Val Arg Phe Lys Val 
    210                 215                 220                 


Pro Gln Gln Ile Leu Gln Gly Leu Val Asp Val Arg Ile Pro His Asn 
225                 230                 235                 240 


Asn Phe Tyr Arg Lys Leu Phe Leu Glu Ile Val Ser Glu Lys Ser Arg 
                245                 250                 255     


Tyr Ser Leu His Gln Asn Met Asp Lys Ile Lys Val Pro Xaa Gln Ile 
            260                 265                 270         


Ile Trp Gly Lys Gln Asp Gln Val Leu Asp Val Ser Gly Ala Asp Met 
        275                 280                 285             


Leu Ala Lys Ser Ile Ala Asn Cys Gln Val Glu Leu Leu Glu Asn Cys 
    290                 295                 300                 


Gly His Ser Val Val Met Glu Arg Pro Arg Lys Xaa Ala Lys Leu Ile 
305                 310                 315                 320 


Ile Asp Phe Leu Ala Ser Val His Asn Xaa Asp Asn Asn Lys Lys Leu 
                325                 330                 335     


Asp 
    


<210> 1281
<211> 329
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<400> 1281
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Ser Gly Lys 
1               5                   10                  15      


Arg Ala Leu Ile Glu Ser Tyr Gln Asn Leu Xaa Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ala Xaa Asp Lys Arg Lys Ala Leu Glu 
        35                  40                  45              


Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr Gln 
    50                  55                  60                  


Ile Asn Ala Leu Ala Asn Asn Val Leu Gln Leu Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln His 
                85                  90                  95      


Gly Asn Asn Gln Pro Ala Arg Xaa Gly Xaa Leu Ser Arg Xaa Asn Pro 
            100                 105                 110         


Pro Xaa Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Arg Gly Xaa Leu 
        115                 120                 125             


Gly Arg Asn Xaa Pro Tyr Lys Xaa Leu Glu Pro Val Lys Pro Pro Xaa 
    130                 135                 140                 


Val Pro Asn Asp Tyr Met Xaa Ser Pro Ala Arg Leu Gly Ser Gln His 
145                 150                 155                 160 


Ser Pro Gly Arg Xaa Ala Ser Leu Asn Gln Arg Pro Arg Xaa His Ser 
                165                 170                 175     


Gly Ser Ser Gly Gly Ser Gly Ser Arg Glu Asn Ser Gly Ser Ser Ser 
            180                 185                 190         


Ile Gly Ile Pro Ile Ala Val Pro Xaa Pro Ser Pro Pro Xaa Ile Gly 
        195                 200                 205             


Pro Val Ala Asp Ser Pro Xaa Pro Pro Pro Pro Pro Pro Pro Asp Asp 
    210                 215                 220                 


Ile Pro Met Phe Asp Asp Ser Pro Pro Pro Pro Pro Pro Pro Pro Val 
225                 230                 235                 240 


Asp Tyr Glu Asp Glu Glu Ala Ala Val Val Gln Tyr Asn Asp Pro Tyr 
                245                 250                 255     


Ala Asp Gly Asp Pro Ala Trp Ala Pro Lys Asn Tyr Ile Glu Lys Val 
            260                 265                 270         


Val Ala Ile Tyr Asp Tyr Xaa Lys Asp Lys Asp Asp Glu Leu Ser Phe 
        275                 280                 285             


Met Glu Gly Ala Ile Ile Tyr Val Ile Lys Lys Asn Asp Asp Gly Trp 
    290                 295                 300                 


Tyr Glu Gly Val Cys Asn Arg Val Xaa Gly Leu Phe Pro Gly Asn Tyr 
305                 310                 315                 320 


Val Glu Ser Ile Met His Tyr Xaa Asp 
                325                 


<210> 1282
<211> 446
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<400> 1282
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Ser Gly Lys 
1               5                   10                  15      


Arg Ala Leu Ile Glu Ser Tyr Gln Asn Leu Xaa Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ala Xaa Asp Lys Arg Lys Ala Leu Glu 
        35                  40                  45              


Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr Gln 
    50                  55                  60                  


Ile Asn Ala Leu Ala Asn Asn Val Leu Gln Leu Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Xaa 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Xaa Xaa Asn Lys Asn Xaa Ser Arg Xaa His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Met Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Xaa 
    130                 135                 140                 


Val Leu Asp Asp Val Gly His Gly Val Lys His Gly Asn Asn Gln Pro 
145                 150                 155                 160 


Ala Arg Xaa Gly Xaa Leu Ser Arg Xaa Asn Pro Pro Xaa Gln Lys Pro 
                165                 170                 175     


Pro Ser Pro Pro Met Ser Gly Arg Gly Xaa Leu Gly Arg Asn Xaa Pro 
            180                 185                 190         


Tyr Lys Xaa Leu Glu Pro Val Lys Pro Pro Xaa Val Pro Asn Asp Tyr 
        195                 200                 205             


Met Xaa Ser Pro Ala Arg Leu Gly Ser Gln His Ser Pro Gly Arg Xaa 
    210                 215                 220                 


Ala Ser Leu Asn Gln Arg Pro Arg Xaa His Ser Gly Ser Ser Gly Gly 
225                 230                 235                 240 


Ser Gly Ser Arg Glu Asn Ser Gly Ser Ser Ser Ile Gly Ile Pro Ile 
                245                 250                 255     


Ala Val Pro Xaa Pro Ser Pro Pro Xaa Ile Gly Pro Ala Pro Gly Ser 
            260                 265                 270         


Ala Pro Gly Ser Gln Tyr Gly Xaa Met Xaa Arg Gln Ile Ser Arg His 
        275                 280                 285             


Asn Ser Xaa Xaa Ser Ser Xaa Ser Ser Gly Gly Tyr Arg Arg Xaa Pro 
    290                 295                 300                 


Ser Val Xaa Ala Gln Phe Ser Ala Gln Pro His Val Asn Gly Gly Pro 
305                 310                 315                 320 


Leu Tyr Ser Gln Asn Ser Ile Ala Asp Ser Pro Xaa Pro Pro Pro Pro 
                325                 330                 335     


Pro Pro Pro Asp Asp Ile Pro Met Phe Asp Asp Ser Pro Pro Pro Pro 
            340                 345                 350         


Pro Pro Pro Pro Val Asp Tyr Glu Asp Glu Glu Ala Ala Val Val Gln 
        355                 360                 365             


Tyr Asn Asp Pro Tyr Ala Asp Gly Asp Pro Ala Trp Ala Pro Lys Asn 
    370                 375                 380                 


Tyr Ile Glu Lys Val Val Ala Ile Tyr Asp Tyr Xaa Lys Asp Lys Asp 
385                 390                 395                 400 


Asp Glu Leu Ser Phe Met Glu Gly Ala Ile Ile Tyr Val Ile Lys Lys 
                405                 410                 415     


Asn Asp Asp Gly Trp Tyr Glu Gly Val Cys Asn Arg Val Xaa Gly Leu 
            420                 425                 430         


Phe Pro Gly Asn Tyr Val Glu Ser Ile Met His Tyr Xaa Asp 
        435                 440                 445     


<210> 1283
<211> 475
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<400> 1283
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Ser Gly Lys 
1               5                   10                  15      


Arg Ala Leu Ile Glu Ser Tyr Gln Asn Leu Xaa Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ala Xaa Asp Lys Arg Lys Ala Leu Glu 
        35                  40                  45              


Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr Gln 
    50                  55                  60                  


Ile Asn Ala Leu Ala Asn Asn Val Leu Gln Leu Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Xaa 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Xaa Xaa Asn Lys Asn Xaa Ser Arg Xaa His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Met Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Xaa 
    130                 135                 140                 


Val Leu Asp Asp Val Gly His Gly Val Lys His Gly Asn Asn Gln Pro 
145                 150                 155                 160 


Ala Arg Xaa Gly Xaa Leu Ser Arg Xaa Asn Pro Pro Xaa Gln Lys Pro 
                165                 170                 175     


Pro Ser Pro Pro Met Ser Gly Arg Gly Xaa Leu Gly Arg Asn Xaa Pro 
            180                 185                 190         


Tyr Lys Xaa Leu Glu Pro Val Lys Pro Pro Xaa Val Pro Asn Asp Tyr 
        195                 200                 205             


Met Xaa Ser Pro Ala Arg Leu Gly Ser Gln His Ser Pro Gly Arg Xaa 
    210                 215                 220                 


Ala Ser Leu Asn Gln Arg Pro Arg Xaa His Ser Gly Ser Ser Gly Gly 
225                 230                 235                 240 


Ser Gly Ser Arg Glu Asn Ser Gly Ser Ser Ser Ile Gly Ile Pro Ile 
                245                 250                 255     


Ala Val Pro Xaa Pro Ser Pro Pro Xaa Ile Gly Pro Ala Pro Gly Ser 
            260                 265                 270         


Ala Pro Gly Ser Gln Tyr Gly Xaa Met Xaa Arg Gln Ile Ser Arg His 
        275                 280                 285             


Asn Ser Xaa Xaa Ser Ser Xaa Ser Ser Gly Gly Tyr Arg Arg Xaa Pro 
    290                 295                 300                 


Ser Val Xaa Ala Gln Phe Ser Ala Gln Pro His Val Asn Gly Gly Pro 
305                 310                 315                 320 


Leu Tyr Ser Gln Asn Ser Ile Ser Ile Ala Pro Pro Pro Pro Pro Met 
                325                 330                 335     


Pro Gln Leu Xaa Pro Gln Ile Pro Leu Xaa Gly Phe Val Ala Arg Val 
            340                 345                 350         


Gln Glu Asn Ile Ala Asp Ser Pro Xaa Pro Pro Pro Pro Pro Pro Pro 
        355                 360                 365             


Asp Asp Ile Pro Met Phe Asp Asp Ser Pro Pro Pro Pro Pro Pro Pro 
    370                 375                 380                 


Pro Val Asp Tyr Glu Asp Glu Glu Ala Ala Val Val Gln Tyr Asn Asp 
385                 390                 395                 400 


Pro Tyr Ala Asp Gly Asp Pro Ala Trp Ala Pro Lys Asn Tyr Ile Glu 
                405                 410                 415     


Lys Val Val Ala Ile Tyr Asp Tyr Xaa Lys Asp Lys Asp Asp Glu Leu 
            420                 425                 430         


Ser Phe Met Glu Gly Ala Ile Ile Tyr Val Ile Lys Lys Asn Asp Asp 
        435                 440                 445             


Gly Trp Tyr Glu Gly Val Cys Asn Arg Val Xaa Gly Leu Phe Pro Gly 
    450                 455                 460                 


Asn Tyr Val Glu Ser Ile Met His Tyr Xaa Asp 
465                 470                 475 


<210> 1284
<211> 476
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<400> 1284
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Ser Gly Lys 
1               5                   10                  15      


Arg Ala Leu Ile Glu Ser Tyr Gln Asn Leu Xaa Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ala Xaa Asp Lys Arg Lys Ala Leu Glu 
        35                  40                  45              


Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr Gln 
    50                  55                  60                  


Ile Asn Ala Leu Ala Asn Asn Val Leu Gln Leu Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Xaa 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Xaa Xaa Asn Lys Asn Xaa Ser Arg Xaa His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Met Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Xaa 
    130                 135                 140                 


Val Leu Asp Asp Val Gly His Gly Val Lys His Gly Asn Asn Gln Pro 
145                 150                 155                 160 


Ala Arg Xaa Gly Xaa Leu Ser Arg Xaa Asn Pro Pro Xaa Gln Lys Pro 
                165                 170                 175     


Pro Ser Pro Pro Met Ser Gly Arg Gly Xaa Leu Gly Arg Asn Xaa Pro 
            180                 185                 190         


Tyr Lys Xaa Leu Glu Pro Val Lys Pro Pro Xaa Val Pro Asn Asp Tyr 
        195                 200                 205             


Met Xaa Ser Pro Ala Arg Leu Gly Ser Gln His Ser Pro Gly Arg Xaa 
    210                 215                 220                 


Ala Ser Leu Asn Gln Arg Pro Arg Xaa His Ser Gly Ser Ser Gly Gly 
225                 230                 235                 240 


Ser Gly Ser Arg Glu Asn Ser Gly Ser Ser Ser Ile Gly Ile Pro Ile 
                245                 250                 255     


Ala Val Pro Xaa Pro Ser Pro Pro Xaa Ile Gly Pro Ala Ala Pro Gly 
            260                 265                 270         


Ser Ala Pro Gly Ser Gln Tyr Gly Xaa Met Xaa Arg Gln Ile Ser Arg 
        275                 280                 285             


His Asn Ser Xaa Xaa Ser Ser Xaa Ser Ser Gly Gly Tyr Arg Arg Xaa 
    290                 295                 300                 


Pro Ser Val Xaa Ala Gln Phe Ser Ala Gln Pro His Val Asn Gly Gly 
305                 310                 315                 320 


Pro Leu Tyr Ser Gln Asn Ser Ile Ser Ile Ala Pro Pro Pro Pro Pro 
                325                 330                 335     


Met Pro Gln Leu Xaa Pro Gln Ile Pro Leu Xaa Gly Phe Val Ala Arg 
            340                 345                 350         


Val Gln Glu Asn Ile Ala Asp Ser Pro Xaa Pro Pro Pro Pro Pro Pro 
        355                 360                 365             


Pro Asp Asp Ile Pro Met Phe Asp Asp Ser Pro Pro Pro Pro Pro Pro 
    370                 375                 380                 


Pro Pro Val Asp Tyr Glu Asp Glu Glu Ala Ala Val Val Gln Tyr Asn 
385                 390                 395                 400 


Asp Pro Tyr Ala Asp Gly Asp Pro Ala Trp Ala Pro Lys Asn Tyr Ile 
                405                 410                 415     


Glu Lys Val Val Ala Ile Tyr Asp Tyr Xaa Lys Asp Lys Asp Asp Glu 
            420                 425                 430         


Leu Ser Phe Met Glu Gly Ala Ile Ile Tyr Val Ile Lys Lys Asn Asp 
        435                 440                 445             


Asp Gly Trp Tyr Glu Gly Val Cys Asn Arg Val Xaa Gly Leu Phe Pro 
    450                 455                 460                 


Gly Asn Tyr Val Glu Ser Ile Met His Tyr Xaa Asp 
465                 470                 475     


<210> 1285
<211> 393
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<400> 1285
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Ser Gly Lys 
1               5                   10                  15      


Arg Ala Leu Ile Glu Ser Tyr Gln Asn Leu Xaa Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ala Xaa Asp Lys Arg Lys Ala Leu Glu 
        35                  40                  45              


Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr Gln 
    50                  55                  60                  


Ile Asn Ala Leu Ala Asn Asn Val Leu Gln Leu Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Xaa 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Xaa Xaa Asn Lys Asn Xaa Ser Arg Xaa His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Met Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Xaa 
    130                 135                 140                 


Val Leu Asp Asp Val Gly His Gly Val Lys Trp Leu Lys Ala Lys His 
145                 150                 155                 160 


Gly Asn Asn Gln Pro Ala Arg Xaa Gly Xaa Leu Ser Arg Xaa Asn Pro 
                165                 170                 175     


Pro Xaa Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Arg Gly Xaa Leu 
            180                 185                 190         


Gly Arg Asn Xaa Pro Tyr Lys Xaa Leu Glu Pro Val Lys Pro Pro Xaa 
        195                 200                 205             


Val Pro Asn Asp Tyr Met Xaa Ser Pro Ala Arg Leu Gly Ser Gln His 
    210                 215                 220                 


Ser Pro Gly Arg Xaa Ala Ser Leu Asn Gln Arg Pro Arg Xaa His Ser 
225                 230                 235                 240 


Gly Ser Ser Gly Gly Ser Gly Ser Arg Glu Asn Ser Gly Ser Ser Ser 
                245                 250                 255     


Ile Gly Ile Pro Ile Ala Val Pro Xaa Pro Ser Pro Pro Xaa Ile Gly 
            260                 265                 270         


Pro Val Ala Asp Ser Pro Xaa Pro Pro Pro Pro Pro Pro Pro Asp Asp 
        275                 280                 285             


Ile Pro Met Phe Asp Asp Ser Pro Pro Pro Pro Pro Pro Pro Pro Val 
    290                 295                 300                 


Asp Tyr Glu Asp Glu Glu Ala Ala Val Val Gln Tyr Asn Asp Pro Tyr 
305                 310                 315                 320 


Ala Asp Gly Asp Pro Ala Trp Ala Pro Lys Asn Tyr Ile Glu Lys Val 
                325                 330                 335     


Val Ala Ile Tyr Asp Tyr Xaa Lys Asp Lys Asp Asp Glu Leu Ser Phe 
            340                 345                 350         


Met Glu Gly Ala Ile Ile Tyr Val Ile Lys Lys Asn Asp Asp Gly Trp 
        355                 360                 365             


Tyr Glu Gly Val Cys Asn Arg Val Xaa Gly Leu Phe Pro Gly Asn Tyr 
    370                 375                 380                 


Val Glu Ser Ile Met His Tyr Xaa Asp 
385                 390             


<210> 1286
<211> 422
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<400> 1286
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Ser Gly Lys 
1               5                   10                  15      


Arg Ala Leu Ile Glu Ser Tyr Gln Asn Leu Xaa Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ala Xaa Asp Lys Arg Lys Ala Leu Glu 
        35                  40                  45              


Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr Gln 
    50                  55                  60                  


Ile Asn Ala Leu Ala Asn Asn Val Leu Gln Leu Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Xaa 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Xaa Xaa Asn Lys Asn Xaa Ser Arg Xaa His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Met Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Xaa 
    130                 135                 140                 


Val Leu Asp Asp Val Gly His Gly Val Lys Trp Leu Lys Ala Lys His 
145                 150                 155                 160 


Gly Asn Asn Gln Pro Ala Arg Xaa Gly Xaa Leu Ser Arg Xaa Asn Pro 
                165                 170                 175     


Pro Xaa Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Arg Gly Xaa Leu 
            180                 185                 190         


Gly Arg Asn Xaa Pro Tyr Lys Xaa Leu Glu Pro Val Lys Pro Pro Xaa 
        195                 200                 205             


Val Pro Asn Asp Tyr Met Xaa Ser Pro Ala Arg Leu Gly Ser Gln His 
    210                 215                 220                 


Ser Pro Gly Arg Xaa Ala Ser Leu Asn Gln Arg Pro Arg Xaa His Ser 
225                 230                 235                 240 


Gly Ser Ser Gly Gly Ser Gly Ser Arg Glu Asn Ser Gly Ser Ser Ser 
                245                 250                 255     


Ile Gly Ile Pro Ile Ala Val Pro Xaa Pro Ser Pro Pro Xaa Ile Gly 
            260                 265                 270         


Pro Val Ser Ile Ala Pro Pro Pro Pro Pro Met Pro Gln Leu Xaa Pro 
        275                 280                 285             


Gln Ile Pro Leu Xaa Gly Phe Val Ala Arg Val Gln Glu Asn Ile Ala 
    290                 295                 300                 


Asp Ser Pro Xaa Pro Pro Pro Pro Pro Pro Pro Asp Asp Ile Pro Met 
305                 310                 315                 320 


Phe Asp Asp Ser Pro Pro Pro Pro Pro Pro Pro Pro Val Asp Tyr Glu 
                325                 330                 335     


Asp Glu Glu Ala Ala Val Val Gln Tyr Asn Asp Pro Tyr Ala Asp Gly 
            340                 345                 350         


Asp Pro Ala Trp Ala Pro Lys Asn Tyr Ile Glu Lys Val Val Ala Ile 
        355                 360                 365             


Tyr Asp Tyr Xaa Lys Asp Lys Asp Asp Glu Leu Ser Phe Met Glu Gly 
    370                 375                 380                 


Ala Ile Ile Tyr Val Ile Lys Lys Asn Asp Asp Gly Trp Tyr Glu Gly 
385                 390                 395                 400 


Val Cys Asn Arg Val Xaa Gly Leu Phe Pro Gly Asn Tyr Val Glu Ser 
                405                 410                 415     


Ile Met His Tyr Xaa Asp 
            420         


<210> 1287
<211> 451
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<400> 1287
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Ser Gly Lys 
1               5                   10                  15      


Arg Ala Leu Ile Glu Ser Tyr Gln Asn Leu Xaa Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ala Xaa Asp Lys Arg Lys Ala Leu Glu 
        35                  40                  45              


Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr Gln 
    50                  55                  60                  


Ile Asn Ala Leu Ala Asn Asn Val Leu Gln Leu Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Xaa 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Xaa Xaa Asn Lys Asn Xaa Ser Arg Xaa His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Met Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Xaa 
    130                 135                 140                 


Val Leu Asp Asp Val Gly His Gly Val Lys Trp Leu Lys Ala Lys His 
145                 150                 155                 160 


Gly Asn Asn Gln Pro Ala Arg Xaa Gly Xaa Leu Ser Arg Xaa Asn Pro 
                165                 170                 175     


Pro Xaa Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Arg Gly Xaa Leu 
            180                 185                 190         


Gly Arg Asn Xaa Pro Tyr Lys Xaa Leu Glu Pro Val Lys Pro Pro Xaa 
        195                 200                 205             


Val Pro Asn Asp Tyr Met Xaa Ser Pro Ala Arg Leu Gly Ser Gln His 
    210                 215                 220                 


Ser Pro Gly Arg Xaa Ala Ser Leu Asn Gln Arg Pro Arg Xaa His Ser 
225                 230                 235                 240 


Gly Ser Ser Gly Gly Ser Gly Ser Arg Glu Asn Ser Gly Ser Ser Ser 
                245                 250                 255     


Ile Gly Ile Pro Ile Ala Val Pro Xaa Pro Ser Pro Pro Xaa Ile Gly 
            260                 265                 270         


Pro Ala Pro Gly Ser Ala Pro Gly Ser Gln Tyr Gly Xaa Met Xaa Arg 
        275                 280                 285             


Gln Ile Ser Arg His Asn Ser Xaa Xaa Ser Ser Xaa Ser Ser Gly Gly 
    290                 295                 300                 


Tyr Arg Arg Xaa Pro Ser Val Xaa Ala Gln Phe Ser Ala Gln Pro His 
305                 310                 315                 320 


Val Asn Gly Gly Pro Leu Tyr Ser Gln Asn Ser Ile Ala Asp Ser Pro 
                325                 330                 335     


Xaa Pro Pro Pro Pro Pro Pro Pro Asp Asp Ile Pro Met Phe Asp Asp 
            340                 345                 350         


Ser Pro Pro Pro Pro Pro Pro Pro Pro Val Asp Tyr Glu Asp Glu Glu 
        355                 360                 365             


Ala Ala Val Val Gln Tyr Asn Asp Pro Tyr Ala Asp Gly Asp Pro Ala 
    370                 375                 380                 


Trp Ala Pro Lys Asn Tyr Ile Glu Lys Val Val Ala Ile Tyr Asp Tyr 
385                 390                 395                 400 


Xaa Lys Asp Lys Asp Asp Glu Leu Ser Phe Met Glu Gly Ala Ile Ile 
                405                 410                 415     


Tyr Val Ile Lys Lys Asn Asp Asp Gly Trp Tyr Glu Gly Val Cys Asn 
            420                 425                 430         


Arg Val Xaa Gly Leu Phe Pro Gly Asn Tyr Val Glu Ser Ile Met His 
        435                 440                 445             


Tyr Xaa Asp 
    450     


<210> 1288
<211> 452
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<400> 1288
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Ser Gly Lys 
1               5                   10                  15      


Arg Ala Leu Ile Glu Ser Tyr Gln Asn Leu Xaa Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ala Xaa Asp Lys Arg Lys Ala Leu Glu 
        35                  40                  45              


Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr Gln 
    50                  55                  60                  


Ile Asn Ala Leu Ala Asn Asn Val Leu Gln Leu Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Xaa 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Xaa Xaa Asn Lys Asn Xaa Ser Arg Xaa His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Met Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Xaa 
    130                 135                 140                 


Val Leu Asp Asp Val Gly His Gly Val Lys Trp Leu Lys Ala Lys His 
145                 150                 155                 160 


Gly Asn Asn Gln Pro Ala Arg Xaa Gly Xaa Leu Ser Arg Xaa Asn Pro 
                165                 170                 175     


Pro Xaa Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Arg Gly Xaa Leu 
            180                 185                 190         


Gly Arg Asn Xaa Pro Tyr Lys Xaa Leu Glu Pro Val Lys Pro Pro Xaa 
        195                 200                 205             


Val Pro Asn Asp Tyr Met Xaa Ser Pro Ala Arg Leu Gly Ser Gln His 
    210                 215                 220                 


Ser Pro Gly Arg Xaa Ala Ser Leu Asn Gln Arg Pro Arg Xaa His Ser 
225                 230                 235                 240 


Gly Ser Ser Gly Gly Ser Gly Ser Arg Glu Asn Ser Gly Ser Ser Ser 
                245                 250                 255     


Ile Gly Ile Pro Ile Ala Val Pro Xaa Pro Ser Pro Pro Xaa Ile Gly 
            260                 265                 270         


Pro Ala Ala Pro Gly Ser Ala Pro Gly Ser Gln Tyr Gly Xaa Met Xaa 
        275                 280                 285             


Arg Gln Ile Ser Arg His Asn Ser Xaa Xaa Ser Ser Xaa Ser Ser Gly 
    290                 295                 300                 


Gly Tyr Arg Arg Xaa Pro Ser Val Xaa Ala Gln Phe Ser Ala Gln Pro 
305                 310                 315                 320 


His Val Asn Gly Gly Pro Leu Tyr Ser Gln Asn Ser Ile Ala Asp Ser 
                325                 330                 335     


Pro Xaa Pro Pro Pro Pro Pro Pro Pro Asp Asp Ile Pro Met Phe Asp 
            340                 345                 350         


Asp Ser Pro Pro Pro Pro Pro Pro Pro Pro Val Asp Tyr Glu Asp Glu 
        355                 360                 365             


Glu Ala Ala Val Val Gln Tyr Asn Asp Pro Tyr Ala Asp Gly Asp Pro 
    370                 375                 380                 


Ala Trp Ala Pro Lys Asn Tyr Ile Glu Lys Val Val Ala Ile Tyr Asp 
385                 390                 395                 400 


Tyr Xaa Lys Asp Lys Asp Asp Glu Leu Ser Phe Met Glu Gly Ala Ile 
                405                 410                 415     


Ile Tyr Val Ile Lys Lys Asn Asp Asp Gly Trp Tyr Glu Gly Val Cys 
            420                 425                 430         


Asn Arg Val Xaa Gly Leu Phe Pro Gly Asn Tyr Val Glu Ser Ile Met 
        435                 440                 445             


His Tyr Xaa Asp 
    450         


<210> 1289
<211> 480
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<400> 1289
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Ser Gly Lys 
1               5                   10                  15      


Arg Ala Leu Ile Glu Ser Tyr Gln Asn Leu Xaa Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ala Xaa Asp Lys Arg Lys Ala Leu Glu 
        35                  40                  45              


Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr Gln 
    50                  55                  60                  


Ile Asn Ala Leu Ala Asn Asn Val Leu Gln Leu Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Xaa 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Xaa Xaa Asn Lys Asn Xaa Ser Arg Xaa His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Met Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Xaa 
    130                 135                 140                 


Val Leu Asp Asp Val Gly His Gly Val Lys Trp Leu Lys Ala Lys His 
145                 150                 155                 160 


Gly Asn Asn Gln Pro Ala Arg Xaa Gly Xaa Leu Ser Arg Xaa Asn Pro 
                165                 170                 175     


Pro Xaa Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Arg Gly Xaa Leu 
            180                 185                 190         


Gly Arg Asn Xaa Pro Tyr Lys Xaa Leu Glu Pro Val Lys Pro Pro Xaa 
        195                 200                 205             


Val Pro Asn Asp Tyr Met Xaa Ser Pro Ala Arg Leu Gly Ser Gln His 
    210                 215                 220                 


Ser Pro Gly Arg Xaa Ala Ser Leu Asn Gln Arg Pro Arg Xaa His Ser 
225                 230                 235                 240 


Gly Ser Ser Gly Gly Ser Gly Ser Arg Glu Asn Ser Gly Ser Ser Ser 
                245                 250                 255     


Ile Gly Ile Pro Ile Ala Val Pro Xaa Pro Ser Pro Pro Xaa Ile Gly 
            260                 265                 270         


Pro Ala Pro Gly Ser Ala Pro Gly Ser Gln Tyr Gly Xaa Met Xaa Arg 
        275                 280                 285             


Gln Ile Ser Arg His Asn Ser Xaa Xaa Ser Ser Xaa Ser Ser Gly Gly 
    290                 295                 300                 


Tyr Arg Arg Xaa Pro Ser Val Xaa Ala Gln Phe Ser Ala Gln Pro His 
305                 310                 315                 320 


Val Asn Gly Gly Pro Leu Tyr Ser Gln Asn Ser Ile Ser Ile Ala Pro 
                325                 330                 335     


Pro Pro Pro Pro Met Pro Gln Leu Xaa Pro Gln Ile Pro Leu Xaa Gly 
            340                 345                 350         


Phe Val Ala Arg Val Gln Glu Asn Ile Ala Asp Ser Pro Xaa Pro Pro 
        355                 360                 365             


Pro Pro Pro Pro Pro Asp Asp Ile Pro Met Phe Asp Asp Ser Pro Pro 
    370                 375                 380                 


Pro Pro Pro Pro Pro Pro Val Asp Tyr Glu Asp Glu Glu Ala Ala Val 
385                 390                 395                 400 


Val Gln Tyr Asn Asp Pro Tyr Ala Asp Gly Asp Pro Ala Trp Ala Pro 
                405                 410                 415     


Lys Asn Tyr Ile Glu Lys Val Val Ala Ile Tyr Asp Tyr Xaa Lys Asp 
            420                 425                 430         


Lys Asp Asp Glu Leu Ser Phe Met Glu Gly Ala Ile Ile Tyr Val Ile 
        435                 440                 445             


Lys Lys Asn Asp Asp Gly Trp Tyr Glu Gly Val Cys Asn Arg Val Xaa 
    450                 455                 460                 


Gly Leu Phe Pro Gly Asn Tyr Val Glu Ser Ile Met His Tyr Xaa Asp 
465                 470                 475                 480 


<210> 1290
<211> 481
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<400> 1290
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Ser Gly Lys 
1               5                   10                  15      


Arg Ala Leu Ile Glu Ser Tyr Gln Asn Leu Xaa Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ala Xaa Asp Lys Arg Lys Ala Leu Glu 
        35                  40                  45              


Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr Gln 
    50                  55                  60                  


Ile Asn Ala Leu Ala Asn Asn Val Leu Gln Leu Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Xaa 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Xaa Xaa Asn Lys Asn Xaa Ser Arg Xaa His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Met Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Xaa 
    130                 135                 140                 


Val Leu Asp Asp Val Gly His Gly Val Lys Trp Leu Lys Ala Lys His 
145                 150                 155                 160 


Gly Asn Asn Gln Pro Ala Arg Xaa Gly Xaa Leu Ser Arg Xaa Asn Pro 
                165                 170                 175     


Pro Xaa Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Arg Gly Xaa Leu 
            180                 185                 190         


Gly Arg Asn Xaa Pro Tyr Lys Xaa Leu Glu Pro Val Lys Pro Pro Xaa 
        195                 200                 205             


Val Pro Asn Asp Tyr Met Xaa Ser Pro Ala Arg Leu Gly Ser Gln His 
    210                 215                 220                 


Ser Pro Gly Arg Xaa Ala Ser Leu Asn Gln Arg Pro Arg Xaa His Ser 
225                 230                 235                 240 


Gly Ser Ser Gly Gly Ser Gly Ser Arg Glu Asn Ser Gly Ser Ser Ser 
                245                 250                 255     


Ile Gly Ile Pro Ile Ala Val Pro Xaa Pro Ser Pro Pro Xaa Ile Gly 
            260                 265                 270         


Pro Ala Ala Pro Gly Ser Ala Pro Gly Ser Gln Tyr Gly Xaa Met Xaa 
        275                 280                 285             


Arg Gln Ile Ser Arg His Asn Ser Xaa Xaa Ser Ser Xaa Ser Ser Gly 
    290                 295                 300                 


Gly Tyr Arg Arg Xaa Pro Ser Val Xaa Ala Gln Phe Ser Ala Gln Pro 
305                 310                 315                 320 


His Val Asn Gly Gly Pro Leu Tyr Ser Gln Asn Ser Ile Ser Ile Ala 
                325                 330                 335     


Pro Pro Pro Pro Pro Met Pro Gln Leu Xaa Pro Gln Ile Pro Leu Xaa 
            340                 345                 350         


Gly Phe Val Ala Arg Val Gln Glu Asn Ile Ala Asp Ser Pro Xaa Pro 
        355                 360                 365             


Pro Pro Pro Pro Pro Pro Asp Asp Ile Pro Met Phe Asp Asp Ser Pro 
    370                 375                 380                 


Pro Pro Pro Pro Pro Pro Pro Val Asp Tyr Glu Asp Glu Glu Ala Ala 
385                 390                 395                 400 


Val Val Gln Tyr Asn Asp Pro Tyr Ala Asp Gly Asp Pro Ala Trp Ala 
                405                 410                 415     


Pro Lys Asn Tyr Ile Glu Lys Val Val Ala Ile Tyr Asp Tyr Xaa Lys 
            420                 425                 430         


Asp Lys Asp Asp Glu Leu Ser Phe Met Glu Gly Ala Ile Ile Tyr Val 
        435                 440                 445             


Ile Lys Lys Asn Asp Asp Gly Trp Tyr Glu Gly Val Cys Asn Arg Val 
    450                 455                 460                 


Xaa Gly Leu Phe Pro Gly Asn Tyr Val Glu Ser Ile Met His Tyr Xaa 
465                 470                 475                 480 


Asp 
    


<210> 1291
<211> 508
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<400> 1291
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Ser Gly Lys 
1               5                   10                  15      


Arg Ala Leu Ile Glu Ser Tyr Gln Asn Leu Xaa Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ala Xaa Asp Lys Arg Lys Ala Leu Glu 
        35                  40                  45              


Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr Gln 
    50                  55                  60                  


Ile Asn Ala Leu Ala Asn Asn Val Leu Gln Leu Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Xaa 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Xaa Xaa Asn Lys Asn Xaa Ser Arg Xaa His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Met Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Xaa 
    130                 135                 140                 


Val Leu Asp Asp Val Gly His Gly Val Lys Trp Leu Lys Ala Lys His 
145                 150                 155                 160 


Gly Asn Asn Gln Pro Ala Arg Xaa Gly Xaa Leu Ser Arg Xaa Asn Pro 
                165                 170                 175     


Pro Xaa Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Arg Gly Xaa Leu 
            180                 185                 190         


Gly Arg Asn Xaa Pro Tyr Lys Xaa Leu Glu Pro Val Lys Pro Pro Xaa 
        195                 200                 205             


Val Pro Asn Asp Tyr Met Xaa Ser Pro Ala Arg Leu Gly Ser Gln His 
    210                 215                 220                 


Ser Pro Gly Arg Xaa Ala Ser Leu Asn Gln Arg Pro Arg Xaa His Ser 
225                 230                 235                 240 


Gly Ser Ser Gly Gly Ser Gly Ser Arg Glu Asn Ser Gly Ser Ser Ser 
                245                 250                 255     


Ile Gly Ile Pro Ile Ala Val Pro Xaa Pro Ser Pro Pro Xaa Ile Gly 
            260                 265                 270         


Pro Glu Asn Ile Ser Val Pro Pro Pro Ser Gly Ala Pro Pro Ala Pro 
        275                 280                 285             


Pro Leu Ala Pro Leu Leu Pro Val Ser Xaa Val Ile Ala Ala Pro Gly 
    290                 295                 300                 


Ser Ala Pro Gly Ser Gln Tyr Gly Xaa Met Xaa Arg Gln Ile Ser Arg 
305                 310                 315                 320 


His Asn Ser Xaa Xaa Ser Ser Xaa Ser Ser Gly Gly Tyr Arg Arg Xaa 
                325                 330                 335     


Pro Ser Val Xaa Ala Gln Phe Ser Ala Gln Pro His Val Asn Gly Gly 
            340                 345                 350         


Pro Leu Tyr Ser Gln Asn Ser Ile Ser Ile Ala Pro Pro Pro Pro Pro 
        355                 360                 365             


Met Pro Gln Leu Xaa Pro Gln Ile Pro Leu Xaa Gly Phe Val Ala Arg 
    370                 375                 380                 


Val Gln Glu Asn Ile Ala Asp Ser Pro Xaa Pro Pro Pro Pro Pro Pro 
385                 390                 395                 400 


Pro Asp Asp Ile Pro Met Phe Asp Asp Ser Pro Pro Pro Pro Pro Pro 
                405                 410                 415     


Pro Pro Val Asp Tyr Glu Asp Glu Glu Ala Ala Val Val Gln Tyr Asn 
            420                 425                 430         


Asp Pro Tyr Ala Asp Gly Asp Pro Ala Trp Ala Pro Lys Asn Tyr Ile 
        435                 440                 445             


Glu Lys Val Val Ala Ile Tyr Asp Tyr Xaa Lys Asp Lys Asp Asp Glu 
    450                 455                 460                 


Leu Ser Phe Met Glu Gly Ala Ile Ile Tyr Val Ile Lys Lys Asn Asp 
465                 470                 475                 480 


Asp Gly Trp Tyr Glu Gly Val Cys Asn Arg Val Xaa Gly Leu Phe Pro 
                485                 490                 495     


Gly Asn Tyr Val Glu Ser Ile Met His Tyr Xaa Asp 
            500                 505             


<210> 1292
<211> 496
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<400> 1292
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Ser Gly Lys 
1               5                   10                  15      


Arg Ala Leu Ile Glu Ser Tyr Gln Asn Leu Xaa Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Arg His Gly Phe Ala Val Leu Leu Cys 
        35                  40                  45              


Leu Leu Ser Asn Ser Trp Pro Gln Ala Xaa Asp Lys Arg Lys Ala Leu 
    50                  55                  60                  


Glu Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr 
65                  70                  75                  80  


Gln Ile Asn Ala Leu Ala Asn Asn Val Leu Gln Leu Leu Asp Ile Gln 
                85                  90                  95      


Ala Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln 
            100                 105                 110         


Xaa Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile 
        115                 120                 125             


Leu Xaa Xaa Asn Lys Asn Xaa Ser Arg Xaa His Lys Ile Ile Ala Pro 
    130                 135                 140                 


Ala Asn Met Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr 
145                 150                 155                 160 


Xaa Val Leu Asp Asp Val Gly His Gly Val Lys Trp Leu Lys Ala Lys 
                165                 170                 175     


His Gly Asn Asn Gln Pro Ala Arg Xaa Gly Xaa Leu Ser Arg Xaa Asn 
            180                 185                 190         


Pro Pro Xaa Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Arg Gly Xaa 
        195                 200                 205             


Leu Gly Arg Asn Xaa Pro Tyr Lys Xaa Leu Glu Pro Val Lys Pro Pro 
    210                 215                 220                 


Xaa Val Pro Asn Asp Tyr Met Xaa Ser Pro Ala Arg Leu Gly Ser Gln 
225                 230                 235                 240 


His Ser Pro Gly Arg Xaa Ala Ser Leu Asn Gln Arg Pro Arg Xaa His 
                245                 250                 255     


Ser Gly Ser Ser Gly Gly Ser Gly Ser Arg Glu Asn Ser Gly Ser Ser 
            260                 265                 270         


Ser Ile Gly Ile Pro Ile Ala Val Pro Xaa Pro Ser Pro Pro Xaa Ile 
        275                 280                 285             


Gly Pro Glu Asn Ile Ser Val Pro Pro Pro Ser Gly Ala Pro Pro Ala 
    290                 295                 300                 


Pro Pro Leu Ala Pro Leu Leu Pro Val Ser Xaa Val Ile Ala Ala Pro 
305                 310                 315                 320 


Gly Ser Ala Pro Gly Ser Gln Tyr Gly Xaa Met Xaa Arg Gln Ile Ser 
                325                 330                 335     


Arg His Asn Ser Xaa Xaa Ser Ser Xaa Ser Ser Gly Gly Tyr Arg Arg 
            340                 345                 350         


Xaa Pro Ser Val Xaa Ala Gln Phe Ser Ala Gln Pro His Val Asn Gly 
        355                 360                 365             


Gly Pro Leu Tyr Ser Gln Asn Ser Ile Ala Asp Ser Pro Xaa Pro Pro 
    370                 375                 380                 


Pro Pro Pro Pro Pro Asp Asp Ile Pro Met Phe Asp Asp Ser Pro Pro 
385                 390                 395                 400 


Pro Pro Pro Pro Pro Pro Val Asp Tyr Glu Asp Glu Glu Ala Ala Val 
                405                 410                 415     


Val Gln Tyr Asn Asp Pro Tyr Ala Asp Gly Asp Pro Ala Trp Ala Pro 
            420                 425                 430         


Lys Asn Tyr Ile Glu Lys Val Val Ala Ile Tyr Asp Tyr Xaa Lys Asp 
        435                 440                 445             


Lys Asp Asp Glu Leu Ser Phe Met Glu Gly Ala Ile Ile Tyr Val Ile 
    450                 455                 460                 


Lys Lys Asn Asp Asp Gly Trp Tyr Glu Gly Val Cys Asn Arg Val Xaa 
465                 470                 475                 480 


Gly Leu Phe Pro Gly Asn Tyr Val Glu Ser Ile Met His Tyr Xaa Asp 
                485                 490                 495     


<210> 1293
<211> 59
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<400> 1293
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Xaa Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ala Phe Arg Phe Asp Ser Ala Tyr Pro 
        35                  40                  45              


Leu Val Leu Pro Asp Lys Glu Tyr Met Glu Ser 
    50                  55                  


<210> 1294
<211> 44
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<400> 1294
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Xaa Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ile Ser Arg Glu Pro 
        35                  40                  


<210> 1295
<211> 53
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<400> 1295
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Xaa Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Leu Leu Ser Ile Phe Pro Phe Cys Glu 
        35                  40                  45              


Val Ser Val Ser Arg 
    50              


<210> 1296
<211> 75
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<400> 1296
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Xaa Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Arg Trp Gly Leu Gly Met Ser Cys Arg 
        35                  40                  45              


Leu Glu Cys Ser Gly Val Ile Ile Ala His Cys Ser Leu Glu Leu Leu 
    50                  55                  60                  


Cys Ser Ser Asp His Pro Ala Ser Val Ser Gln 
65                  70                  75  


<210> 1297
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<400> 1297
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Xaa Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ser Ala Asp Lys Gln Arg Ala Leu Glu 
        35                  40                  45              


Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr Leu 
    50                  55                  60                  


Ile Asn Xaa Leu Ala Asn Asn Val Leu Gln Met Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Met 
                85                  90                  95      


Phe Ser His Xaa Asp Gly Gln Leu Xaa Glu Ala Asn 
            100                 105             


<210> 1298
<211> 475
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<400> 1298
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Xaa Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ser Ala Asp Lys Gln Arg Ala Leu Glu 
        35                  40                  45              


Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr Leu 
    50                  55                  60                  


Ile Asn Xaa Leu Ala Asn Asn Val Leu Gln Met Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Xaa 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Xaa Xaa Asn Lys Asn Xaa Ser Arg Xaa His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Leu Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Xaa 
    130                 135                 140                 


Ile Leu Asp Asp Ile Gly His Gly Val Lys Val Ser Xaa Gln Asn Met 
145                 150                 155                 160 


Lys Met Gly Gly Leu Pro Arg Xaa Xaa Pro Pro Xaa Gln Lys Pro Pro 
                165                 170                 175     


Ser Pro Pro Met Ser Gly Lys Gly Xaa Leu Gly Arg His Ser Pro Tyr 
            180                 185                 190         


Arg Xaa Leu Glu Pro Val Arg Pro Pro Val Val Pro Asn Asp Tyr Val 
        195                 200                 205             


Pro Ser Pro Xaa Arg Asn Met Ala Pro Ser Gln Gln Ser Pro Val Arg 
    210                 215                 220                 


Xaa Ala Ser Val Asn Gln Arg Asn Arg Xaa Tyr Ser Ser Ser Gly Ser 
225                 230                 235                 240 


Ser Gly Gly Ser His Pro Ser Ser Arg Ser Ser Ser Arg Glu Asn Ser 
                245                 250                 255     


Gly Ser Gly Ser Val Gly Val Pro Ile Ala Val Pro Xaa Pro Ser Pro 
            260                 265                 270         


Pro Ser Val Phe Pro Gly His Pro Val Gln Phe Tyr Ser Met Asn Arg 
        275                 280                 285             


Pro Ala Ser Arg His Xaa Pro Pro Xaa Ile Gly Gly Ser Leu Pro Tyr 
    290                 295                 300                 


Arg Arg Pro Pro Ser Ile Xaa Ser Gln Xaa Ser Leu Gln Asn Gln Met 
305                 310                 315                 320 


Asn Gly Gly Pro Phe Tyr Ser Gln Asn Pro Val Ser Leu Ala Pro Pro 
                325                 330                 335     


Pro Pro Ser Ile Leu Gln Val Xaa Pro Gln Leu Pro Leu Met Gly Phe 
            340                 345                 350         


Val Ala Arg Val Gln Glu Asn Ile Ser Asp Xaa Pro Pro Pro Pro Pro 
        355                 360                 365             


Pro Val Glu Glu Pro Val Phe Asp Glu Ser Pro Pro Pro Pro Pro Pro 
    370                 375                 380                 


Pro Glu Asp Tyr Glu Glu Glu Glu Ala Ala Val Val Glu Tyr Ser Asp 
385                 390                 395                 400 


Pro Tyr Ala Glu Glu Asp Pro Pro Trp Ala Pro Arg Ser Tyr Leu Glu 
                405                 410                 415     


Lys Val Val Ala Ile Tyr Asp Tyr Xaa Lys Asp Lys Glu Asp Glu Leu 
            420                 425                 430         


Ser Phe Gln Glu Gly Ala Ile Ile Tyr Val Ile Lys Lys Asn Asp Asp 
        435                 440                 445             


Gly Trp Tyr Glu Gly Val Met Asn Gly Val Xaa Gly Leu Phe Pro Gly 
    450                 455                 460                 


Asn Tyr Val Glu Ser Ile Met His Tyr Ser Glu 
465                 470                 475 


<210> 1299
<211> 507
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<400> 1299
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Xaa Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ser Ala Asp Lys Gln Arg Ala Leu Glu 
        35                  40                  45              


Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr Leu 
    50                  55                  60                  


Ile Asn Xaa Leu Ala Asn Asn Val Leu Gln Met Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Xaa 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Xaa Xaa Asn Lys Asn Xaa Ser Arg Xaa His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Leu Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Xaa 
    130                 135                 140                 


Ile Leu Asp Asp Ile Gly His Gly Val Lys Val Ser Xaa Gln Asn Met 
145                 150                 155                 160 


Lys Met Gly Gly Leu Pro Arg Xaa Xaa Pro Pro Xaa Gln Lys Pro Pro 
                165                 170                 175     


Ser Pro Pro Met Ser Gly Lys Gly Xaa Leu Gly Arg His Ser Pro Tyr 
            180                 185                 190         


Arg Xaa Leu Glu Pro Val Arg Pro Pro Val Val Pro Asn Asp Tyr Val 
        195                 200                 205             


Pro Ser Pro Xaa Arg Asn Met Ala Pro Ser Gln Gln Ser Pro Val Arg 
    210                 215                 220                 


Xaa Ala Ser Val Asn Gln Arg Asn Arg Xaa Tyr Ser Ser Ser Gly Ser 
225                 230                 235                 240 


Ser Gly Gly Ser His Pro Ser Ser Arg Ser Ser Ser Arg Glu Asn Ser 
                245                 250                 255     


Gly Ser Gly Ser Val Gly Val Pro Ile Ala Val Pro Xaa Pro Ser Pro 
            260                 265                 270         


Pro Ser Val Phe Pro Ala Pro Ala Gly Ser Ala Gly Xaa Pro Pro Leu 
        275                 280                 285             


Pro Ala Xaa Ser Ala Ser Ala Pro Ala Pro Leu Val Pro Ala Xaa Val 
    290                 295                 300                 


Pro Ser Ser Xaa Ala Pro Asp Ala Ala Ala Gly Gly Ala Gln Xaa Leu 
305                 310                 315                 320 


Ala Asp Gly Phe Xaa Ser Pro Xaa Pro Pro Val Val Ser Ser Xaa Pro 
                325                 330                 335     


Pro Xaa Gly His Pro Val Gln Phe Tyr Ser Met Asn Arg Pro Ala Ser 
            340                 345                 350         


Arg His Xaa Pro Pro Xaa Ile Gly Gly Ser Leu Pro Tyr Arg Arg Pro 
        355                 360                 365             


Pro Ser Ile Xaa Ser Gln Xaa Ser Leu Gln Asn Gln Met Asn Gly Gly 
    370                 375                 380                 


Pro Phe Tyr Ser Gln Asn Pro Val Ser Asp Xaa Pro Pro Pro Pro Pro 
385                 390                 395                 400 


Pro Val Glu Glu Pro Val Phe Asp Glu Ser Pro Pro Pro Pro Pro Pro 
                405                 410                 415     


Pro Glu Asp Tyr Glu Glu Glu Glu Ala Ala Val Val Glu Tyr Ser Asp 
            420                 425                 430         


Pro Tyr Ala Glu Glu Asp Pro Pro Trp Ala Pro Arg Ser Tyr Leu Glu 
        435                 440                 445             


Lys Val Val Ala Ile Tyr Asp Tyr Xaa Lys Asp Lys Glu Asp Glu Leu 
    450                 455                 460                 


Ser Phe Gln Glu Gly Ala Ile Ile Tyr Val Ile Lys Lys Asn Asp Asp 
465                 470                 475                 480 


Gly Trp Tyr Glu Gly Val Met Asn Gly Val Xaa Gly Leu Phe Pro Gly 
                485                 490                 495     


Asn Tyr Val Glu Ser Ile Met His Tyr Ser Glu 
            500                 505         


<210> 1300
<211> 458
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<400> 1300
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Xaa Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ser Ala Asp Lys Gln Arg Ala Leu Glu 
        35                  40                  45              


Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr Leu 
    50                  55                  60                  


Ile Asn Xaa Leu Ala Asn Asn Val Leu Gln Met Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Xaa 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Xaa Xaa Asn Lys Asn Xaa Ser Arg Xaa His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Leu Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Xaa 
    130                 135                 140                 


Ile Leu Asp Asp Ile Gly His Gly Val Lys Val Ser Xaa Gln Asn Met 
145                 150                 155                 160 


Lys Met Gly Gly Leu Pro Arg Xaa Xaa Pro Pro Xaa Gln Lys Pro Pro 
                165                 170                 175     


Ser Pro Pro Met Ser Gly Lys Gly Xaa Leu Gly Ser Ser Gly Ser Ser 
            180                 185                 190         


Gly Gly Ser His Pro Ser Ser Arg Ser Ser Ser Arg Glu Asn Ser Gly 
        195                 200                 205             


Ser Gly Ser Val Gly Val Pro Ile Ala Val Pro Xaa Pro Ser Pro Pro 
    210                 215                 220                 


Ser Val Phe Pro Ala Pro Ala Gly Ser Ala Gly Xaa Pro Pro Leu Pro 
225                 230                 235                 240 


Ala Xaa Ser Ala Ser Ala Pro Ala Pro Leu Val Pro Ala Xaa Val Pro 
                245                 250                 255     


Ser Ser Xaa Ala Pro Asp Ala Ala Ala Gly Gly Ala Gln Xaa Leu Ala 
            260                 265                 270         


Asp Gly Phe Xaa Ser Pro Xaa Pro Pro Val Val Ser Ser Xaa Pro Pro 
        275                 280                 285             


Xaa Gly His Pro Val Gln Phe Tyr Ser Met Asn Arg Pro Ala Ser Arg 
    290                 295                 300                 


His Xaa Pro Pro Xaa Ile Gly Gly Ser Leu Pro Tyr Arg Arg Pro Pro 
305                 310                 315                 320 


Ser Ile Xaa Ser Gln Xaa Ser Leu Gln Asn Gln Met Asn Gly Gly Pro 
                325                 330                 335     


Phe Tyr Ser Gln Asn Pro Val Ser Asp Xaa Pro Pro Pro Pro Pro Pro 
            340                 345                 350         


Val Glu Glu Pro Val Phe Asp Glu Ser Pro Pro Pro Pro Pro Pro Pro 
        355                 360                 365             


Glu Asp Tyr Glu Glu Glu Glu Ala Ala Val Val Glu Tyr Ser Asp Pro 
    370                 375                 380                 


Tyr Ala Glu Glu Asp Pro Pro Trp Ala Pro Arg Ser Tyr Leu Glu Lys 
385                 390                 395                 400 


Val Val Ala Ile Tyr Asp Tyr Xaa Lys Asp Lys Glu Asp Glu Leu Ser 
                405                 410                 415     


Phe Gln Glu Gly Ala Ile Ile Tyr Val Ile Lys Lys Asn Asp Asp Gly 
            420                 425                 430         


Trp Tyr Glu Gly Val Met Asn Gly Val Xaa Gly Leu Phe Pro Gly Asn 
        435                 440                 445             


Tyr Val Glu Ser Ile Met His Tyr Ser Glu 
    450                 455             


<210> 1301
<211> 480
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<400> 1301
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Xaa Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ser Ala Asp Lys Gln Arg Ala Leu Glu 
        35                  40                  45              


Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr Leu 
    50                  55                  60                  


Ile Asn Xaa Leu Ala Asn Asn Val Leu Gln Met Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Xaa 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Xaa Xaa Asn Lys Asn Xaa Ser Arg Xaa His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Leu Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Xaa 
    130                 135                 140                 


Ile Leu Asp Asp Ile Gly His Gly Val Lys Trp Leu Leu Arg Phe Lys 
145                 150                 155                 160 


Val Ser Xaa Gln Asn Met Lys Met Gly Gly Leu Pro Arg Xaa Xaa Pro 
                165                 170                 175     


Pro Xaa Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Lys Gly Xaa Leu 
            180                 185                 190         


Gly Arg His Ser Pro Tyr Arg Xaa Leu Glu Pro Val Arg Pro Pro Val 
        195                 200                 205             


Val Pro Asn Asp Tyr Val Pro Ser Pro Xaa Arg Asn Met Ala Pro Ser 
    210                 215                 220                 


Gln Gln Ser Pro Val Arg Xaa Ala Ser Val Asn Gln Arg Asn Arg Xaa 
225                 230                 235                 240 


Tyr Ser Ser Ser Gly Ser Ser Gly Gly Ser His Pro Ser Ser Arg Ser 
                245                 250                 255     


Ser Ser Arg Glu Asn Ser Gly Ser Gly Ser Val Gly Val Pro Ile Ala 
            260                 265                 270         


Val Pro Xaa Pro Ser Pro Pro Ser Val Phe Pro Asp Ala Ala Ala Gly 
        275                 280                 285             


Gly Ala Gln Xaa Leu Ala Asp Gly Phe Xaa Ser Pro Xaa Pro Pro Val 
    290                 295                 300                 


Val Ser Ser Xaa Pro Pro Xaa Gly His Pro Val Gln Phe Tyr Ser Met 
305                 310                 315                 320 


Asn Arg Pro Ala Ser Arg His Xaa Pro Pro Xaa Ile Gly Gly Ser Leu 
                325                 330                 335     


Pro Tyr Arg Arg Pro Pro Ser Ile Xaa Ser Gln Xaa Ser Leu Gln Asn 
            340                 345                 350         


Gln Met Asn Gly Gly Pro Phe Tyr Ser Gln Asn Pro Val Ser Asp Xaa 
        355                 360                 365             


Pro Pro Pro Pro Pro Pro Val Glu Glu Pro Val Phe Asp Glu Ser Pro 
    370                 375                 380                 


Pro Pro Pro Pro Pro Pro Glu Asp Tyr Glu Glu Glu Glu Ala Ala Val 
385                 390                 395                 400 


Val Glu Tyr Ser Asp Pro Tyr Ala Glu Glu Asp Pro Pro Trp Ala Pro 
                405                 410                 415     


Arg Ser Tyr Leu Glu Lys Val Val Ala Ile Tyr Asp Tyr Xaa Lys Asp 
            420                 425                 430         


Lys Glu Asp Glu Leu Ser Phe Gln Glu Gly Ala Ile Ile Tyr Val Ile 
        435                 440                 445             


Lys Lys Asn Asp Asp Gly Trp Tyr Glu Gly Val Met Asn Gly Val Xaa 
    450                 455                 460                 


Gly Leu Phe Pro Gly Asn Tyr Val Glu Ser Ile Met His Tyr Ser Glu 
465                 470                 475                 480 


<210> 1302
<211> 486
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<400> 1302
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Xaa Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ser Ala Asp Lys Gln Arg Ala Leu Glu 
        35                  40                  45              


Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr Leu 
    50                  55                  60                  


Ile Asn Xaa Leu Ala Asn Asn Val Leu Gln Met Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Xaa 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Xaa Xaa Asn Lys Asn Xaa Ser Arg Xaa His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Leu Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Xaa 
    130                 135                 140                 


Ile Leu Asp Asp Ile Gly His Gly Val Lys Trp Leu Leu Arg Phe Lys 
145                 150                 155                 160 


Val Ser Xaa Gln Asn Met Lys Met Gly Gly Leu Pro Arg Xaa Xaa Pro 
                165                 170                 175     


Pro Xaa Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Lys Gly Xaa Leu 
            180                 185                 190         


Gly Arg His Ser Pro Tyr Arg Xaa Leu Glu Pro Val Arg Pro Pro Val 
        195                 200                 205             


Val Pro Asn Asp Tyr Val Pro Ser Pro Xaa Arg Asn Met Ala Pro Ser 
    210                 215                 220                 


Gln Gln Ser Pro Val Arg Xaa Ala Ser Val Asn Gln Arg Asn Arg Xaa 
225                 230                 235                 240 


Tyr Ser Ser Ser Gly Ser Ser Gly Gly Ser His Pro Ser Ser Arg Ser 
                245                 250                 255     


Ser Ser Arg Glu Asn Ser Gly Ser Gly Ser Val Gly Val Pro Ile Ala 
            260                 265                 270         


Val Pro Xaa Pro Ser Pro Pro Ser Val Phe Pro Ala Pro Ala Gly Ser 
        275                 280                 285             


Ala Gly Xaa Pro Pro Leu Pro Ala Xaa Ser Ala Ser Ala Pro Ala Pro 
    290                 295                 300                 


Leu Val Pro Ala Xaa Val Pro Ser Ser Xaa Ala Pro Asp Ala Ala Ala 
305                 310                 315                 320 


Gly Gly Ala Gln Xaa Leu Ala Asp Gly Phe Xaa Ser Pro Xaa Pro Pro 
                325                 330                 335     


Val Val Ser Ser Xaa Pro Pro Xaa Gly His Pro Val Gln Phe Tyr Ser 
            340                 345                 350         


Met Asn Arg Pro Ala Ser Arg His Xaa Pro Pro Xaa Ile Gly Gly Ser 
        355                 360                 365             


Leu Pro Tyr Arg Arg Pro Pro Ser Ile Xaa Ser Gln Xaa Ser Leu Gln 
    370                 375                 380                 


Asn Gln Met Asn Gly Gly Pro Phe Tyr Ser Gln Asn Pro Val Ser Asp 
385                 390                 395                 400 


Xaa Pro Pro Pro Pro Pro Pro Val Glu Glu Pro Val Phe Asp Glu Ser 
                405                 410                 415     


Pro Pro Pro Pro Pro Pro Pro Glu Asp Tyr Glu Glu Glu Glu Ala Ala 
            420                 425                 430         


Val Val Glu Tyr Ser Asp Pro Tyr Ala Glu Glu Asp Pro Pro Trp Ala 
        435                 440                 445             


Pro Arg Ser Tyr Leu Glu Lys Val Val Ala Ile Tyr Asp Tyr Xaa Lys 
    450                 455                 460                 


Asp Lys Glu Asp Glu Leu Ser Phe Gln Glu Gly Ala Ile Ile Tyr Val 
465                 470                 475                 480 


Ile Lys Lys Asn Asp Asp 
                485     


<210> 1303
<211> 513
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<400> 1303
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Xaa Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ser Ala Asp Lys Gln Arg Ala Leu Glu 
        35                  40                  45              


Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr Leu 
    50                  55                  60                  


Ile Asn Xaa Leu Ala Asn Asn Val Leu Gln Met Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Xaa 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Xaa Xaa Asn Lys Asn Xaa Ser Arg Xaa His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Leu Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Xaa 
    130                 135                 140                 


Ile Leu Asp Asp Ile Gly His Gly Val Lys Trp Leu Leu Arg Phe Lys 
145                 150                 155                 160 


Val Ser Xaa Gln Asn Met Lys Met Gly Gly Leu Pro Arg Xaa Xaa Pro 
                165                 170                 175     


Pro Xaa Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Lys Gly Xaa Leu 
            180                 185                 190         


Gly Arg His Ser Pro Tyr Arg Xaa Leu Glu Pro Val Arg Pro Pro Val 
        195                 200                 205             


Val Pro Asn Asp Tyr Val Pro Ser Pro Xaa Arg Asn Met Ala Pro Ser 
    210                 215                 220                 


Gln Gln Ser Pro Val Arg Xaa Ala Ser Val Asn Gln Arg Asn Arg Xaa 
225                 230                 235                 240 


Tyr Ser Ser Ser Gly Ser Ser Gly Gly Ser His Pro Ser Ser Arg Ser 
                245                 250                 255     


Ser Ser Arg Glu Asn Ser Gly Ser Gly Ser Val Gly Val Pro Ile Ala 
            260                 265                 270         


Val Pro Xaa Pro Ser Pro Pro Ser Val Phe Pro Ala Pro Ala Gly Ser 
        275                 280                 285             


Ala Gly Xaa Pro Pro Leu Pro Ala Xaa Ser Ala Ser Ala Pro Ala Pro 
    290                 295                 300                 


Leu Val Pro Ala Xaa Val Pro Ser Ser Xaa Ala Pro Asp Ala Ala Ala 
305                 310                 315                 320 


Gly Gly Ala Gln Xaa Leu Ala Asp Gly Phe Xaa Ser Pro Xaa Pro Pro 
                325                 330                 335     


Val Val Ser Ser Xaa Pro Pro Xaa Gly His Pro Val Gln Phe Tyr Ser 
            340                 345                 350         


Met Asn Arg Pro Ala Ser Arg His Xaa Pro Pro Xaa Ile Gly Gly Ser 
        355                 360                 365             


Leu Pro Tyr Arg Arg Pro Pro Ser Ile Xaa Ser Gln Xaa Ser Leu Gln 
    370                 375                 380                 


Asn Gln Met Asn Gly Gly Pro Phe Tyr Ser Gln Asn Pro Val Ser Asp 
385                 390                 395                 400 


Xaa Pro Pro Pro Pro Pro Pro Val Glu Glu Pro Val Phe Asp Glu Ser 
                405                 410                 415     


Pro Pro Pro Pro Pro Pro Pro Glu Asp Tyr Glu Glu Glu Glu Ala Ala 
            420                 425                 430         


Val Val Glu Tyr Ser Asp Pro Tyr Ala Glu Glu Asp Pro Pro Trp Ala 
        435                 440                 445             


Pro Arg Ser Tyr Leu Glu Lys Val Val Ala Ile Tyr Asp Tyr Xaa Lys 
    450                 455                 460                 


Asp Lys Glu Asp Glu Leu Ser Phe Gln Glu Gly Ala Ile Ile Tyr Val 
465                 470                 475                 480 


Ile Lys Lys Asn Asp Asp Gly Trp Tyr Glu Gly Val Met Asn Gly Val 
                485                 490                 495     


Xaa Gly Leu Phe Pro Gly Asn Tyr Val Glu Ser Ile Met His Tyr Ser 
            500                 505                 510         


Glu 
    


<210> 1304
<211> 87
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 1304
Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Xaa Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ser Ala Asp Lys Gln Arg Ala Leu Glu 
        35                  40                  45              


Glu Xaa Lys Ala Tyr Xaa Xaa Gln Ser Leu Ala Ser Val Ala Tyr Leu 
    50                  55                  60                  


Ile Asn Xaa Leu Ala Asn Asn Val Leu Gln Met Leu Asp Ile Gln Val 
65                  70                  75                  80  


Ile Leu Tyr Ser Ser Xaa Ala 
                85          


<210> 1305
<211> 390
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<400> 1305
Met Phe Phe Lys Ser Tyr Leu Leu Lys Ile Ser Ile Leu Arg Gln Ile 
1               5                   10                  15      


Arg Gly Val Asp Leu Glu Ser Xaa Phe Val Xaa Lys Phe Gly Asn Asn 
            20                  25                  30          


Cys Ser Leu Arg Leu Asn Glu Xaa Val Asp Ile His Lys Glu Lys Val 
        35                  40                  45              


Ala Arg Arg Glu Ile Gly Ile Leu Xaa Xaa Asn Lys Asn Xaa Ser Arg 
    50                  55                  60                  


Xaa His Lys Ile Ile Ala Pro Ala Asn Leu Glu Arg Pro Val Arg Tyr 
65                  70                  75                  80  


Ile Arg Lys Pro Ile Asp Tyr Xaa Ile Leu Asp Asp Ile Gly His Gly 
                85                  90                  95      


Val Lys Val Ser Xaa Gln Asn Met Lys Met Gly Gly Leu Pro Arg Xaa 
            100                 105                 110         


Xaa Pro Pro Xaa Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Lys Gly 
        115                 120                 125             


Xaa Leu Gly Arg His Ser Pro Tyr Arg Xaa Leu Glu Pro Val Arg Pro 
    130                 135                 140                 


Pro Val Val Pro Asn Asp Tyr Val Pro Ser Pro Xaa Arg Asn Met Ala 
145                 150                 155                 160 


Pro Ser Gln Gln Ser Pro Val Arg Xaa Ala Ser Val Asn Gln Arg Asn 
                165                 170                 175     


Arg Xaa Tyr Ser Ser Ser Gly Ser Ser Gly Gly Ser His Pro Ser Ser 
            180                 185                 190         


Arg Ser Ser Ser Arg Glu Asn Ser Gly Ser Gly Ser Val Gly Val Pro 
        195                 200                 205             


Ile Ala Val Pro Xaa Pro Ser Pro Pro Ser Val Phe Pro Gly His Pro 
    210                 215                 220                 


Val Gln Phe Tyr Ser Met Asn Arg Pro Ala Ser Arg His Xaa Pro Pro 
225                 230                 235                 240 


Xaa Ile Gly Gly Ser Leu Pro Tyr Arg Arg Pro Pro Ser Ile Xaa Ser 
                245                 250                 255     


Gln Xaa Ser Leu Gln Asn Gln Met Asn Gly Gly Pro Phe Tyr Ser Gln 
            260                 265                 270         


Asn Pro Val Ser Asp Xaa Pro Pro Pro Pro Pro Pro Val Glu Glu Pro 
        275                 280                 285             


Val Phe Asp Glu Ser Pro Pro Pro Pro Pro Pro Pro Glu Asp Tyr Glu 
    290                 295                 300                 


Glu Glu Glu Ala Ala Val Val Glu Tyr Ser Asp Pro Tyr Ala Glu Glu 
305                 310                 315                 320 


Asp Pro Pro Trp Ala Pro Arg Ser Tyr Leu Glu Lys Val Val Ala Ile 
                325                 330                 335     


Tyr Asp Tyr Xaa Lys Asp Lys Glu Asp Glu Leu Ser Phe Gln Glu Gly 
            340                 345                 350         


Ala Ile Ile Tyr Val Ile Lys Lys Asn Asp Asp Gly Trp Tyr Glu Gly 
        355                 360                 365             


Val Met Asn Gly Val Xaa Gly Leu Phe Pro Gly Asn Tyr Val Glu Ser 
    370                 375                 380                 


Ile Met His Tyr Ser Glu 
385                 390 


<210> 1306
<211> 201
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<400> 1306
Xaa Leu Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Xaa 
1               5                   10                  15      


Ile Leu Asp Asp Ile Gly His Gly Val Lys Val Ser Xaa Gln Asn Met 
            20                  25                  30          


Lys Met Gly Gly Leu Pro Arg Xaa Xaa Pro Pro Xaa Gln Lys Pro Pro 
        35                  40                  45              


Ser Pro Pro Met Ser Gly Lys Gly Xaa Leu Gly Arg His Ser Pro Tyr 
    50                  55                  60                  


Arg Xaa Leu Glu Pro Val Arg Pro Pro Val Val Pro Asn Asp Tyr Val 
65                  70                  75                  80  


Pro Ser Pro Xaa Arg Asn Met Ala Pro Ser Gln Gln Ser Pro Val Arg 
                85                  90                  95      


Xaa Ala Ser Val Asn Gln Arg Asn Arg Xaa Tyr Ser Ser Gly Ser Ser 
            100                 105                 110         


Gly Gly Ser His Pro Ser Ser Arg Ser Ser Ser Arg Glu Asn Ser Gly 
        115                 120                 125             


Ser Gly Ser Val Gly Val Pro Ile Ala Val Pro Xaa Pro Ser Pro Pro 
    130                 135                 140                 


Ser Val Phe Pro Gly His Pro Val Gln Phe Tyr Ser Met Asn Arg Pro 
145                 150                 155                 160 


Ala Ser Arg His Xaa Pro Pro Xaa Ile Gly Gly Ser Leu Pro Tyr Arg 
                165                 170                 175     


Arg Pro Pro Ser Ile Xaa Ser Gln Xaa Ser Leu Gln Asn Gln Met Asn 
            180                 185                 190         


Gly Gly Pro Phe Tyr Ser Gln Asn Pro 
        195                 200     


<210> 1307
<211> 43
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<400> 1307
Xaa Gln Ser Leu Ala Ser Val Ala Tyr Leu Ile Asn Xaa Leu Ala Asn 
1               5                   10                  15      


Asn Val Leu Gln Met Leu Asp Ile Gln Ala Ser Gln Leu Arg Arg Met 
            20                  25                  30          


Glu Ser Ser Ile Asn His Ile Ser Gln Ala Asn 
        35                  40              


<210> 1308
<211> 293
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<400> 1308
Xaa Val Ser Xaa Gln Asn Met Lys Met Gly Gly Leu Pro Arg Xaa Xaa 
1               5                   10                  15      


Pro Pro Xaa Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Lys Gly Xaa 
            20                  25                  30          


Leu Gly Arg His Ser Pro Tyr Arg Xaa Leu Glu Pro Val Arg Pro Pro 
        35                  40                  45              


Val Val Pro Asn Asp Tyr Val Pro Ser Pro Xaa Arg Asn Met Ala Pro 
    50                  55                  60                  


Ser Gln Gln Ser Pro Val Arg Xaa Ala Ser Val Asn Gln Arg Asn Arg 
65                  70                  75                  80  


Xaa Tyr Ser Ser Ser Gly Ser Ser Gly Gly Ser His Pro Ser Ser Arg 
                85                  90                  95      


Ser Ser Ser Arg Glu Asn Ser Gly Ser Gly Ser Val Gly Val Pro Ile 
            100                 105                 110         


Ala Val Pro Xaa Pro Ser Pro Pro Ser Val Phe Pro Gly His Pro Val 
        115                 120                 125             


Gln Phe Tyr Ser Met Asn Arg Pro Ala Ser Arg His Xaa Pro Pro Xaa 
    130                 135                 140                 


Ile Gly Gly Ser Leu Pro Tyr Arg Arg Pro Pro Ser Ile Xaa Ser Gln 
145                 150                 155                 160 


Xaa Ser Leu Gln Asn Gln Met Asn Gly Gly Pro Phe Tyr Ser Gln Asn 
                165                 170                 175     


Pro Val Ser Asp Xaa Pro Pro Pro Pro Pro Pro Val Glu Glu Pro Val 
            180                 185                 190         


Phe Asp Glu Ser Pro Pro Pro Pro Pro Pro Pro Glu Asp Tyr Glu Glu 
        195                 200                 205             


Glu Glu Ala Ala Val Val Glu Tyr Ser Asp Pro Tyr Ala Glu Glu Asp 
    210                 215                 220                 


Pro Pro Trp Ala Pro Arg Ser Tyr Leu Glu Lys Val Val Ala Ile Tyr 
225                 230                 235                 240 


Asp Tyr Xaa Lys Asp Lys Glu Asp Glu Leu Ser Phe Gln Glu Gly Ala 
                245                 250                 255     


Ile Ile Tyr Val Ile Lys Lys Asn Asp Asp Gly Trp Tyr Glu Gly Val 
            260                 265                 270         


Met Asn Gly Val Xaa Gly Leu Phe Pro Gly Asn Tyr Val Glu Ser Ile 
        275                 280                 285             


Met His Tyr Ser Glu 
    290             


<210> 1309
<211> 64
<212> PRT
<213> Homo sapiens

<400> 1309
Met Gly Gln Gln Pro Gly Lys Val Leu Gly Asp Gln Arg Arg Pro Ser 
1               5                   10                  15      


Leu Pro Ala Leu His Phe Ile Lys Gly Ala Gly Lys Lys Glu Ser Ser 
            20                  25                  30          


Arg His Gly Gly Pro His Cys Asn Val Phe Val Glu His Ala Leu Gln 
        35                  40                  45              


Arg Pro Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala 
    50                  55                  60                  


<210> 1310
<211> 1149
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (873)..(873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<400> 1310
Met Gly Gln Gln Pro Gly Lys Val Leu Gly Asp Gln Arg Arg Pro Ser 
1               5                   10                  15      


Leu Pro Ala Leu His Phe Ile Lys Gly Ala Gly Lys Lys Glu Ser Ser 
            20                  25                  30          


Arg His Gly Gly Pro His Cys Asn Val Phe Val Glu His Glu Ala Leu 
        35                  40                  45              


Gln Arg Pro Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala 
    50                  55                  60                  


Ala Arg Trp Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn 
65                  70                  75                  80  


Asp Pro Asn Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp 
                85                  90                  95      


Asn Xaa Leu Ser Ile Xaa Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr 
            100                 105                 110         


Asn His Asn Gly Glu Trp Cys Glu Ala Gln Xaa Lys Asn Gly Gln Gly 
        115                 120                 125             


Trp Val Pro Ser Asn Tyr Ile Xaa Pro Val Asn Ser Leu Glu Lys His 
    130                 135                 140                 


Ser Trp Tyr His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu 
145                 150                 155                 160 


Ser Ser Gly Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser 
                165                 170                 175     


Pro Gly Gln Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His 
            180                 185                 190         


Tyr Arg Ile Asn Xaa Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu 
        195                 200                 205             


Ser Arg Phe Asn Xaa Leu Ala Glu Leu Val His His His Ser Xaa Val 
    210                 215                 220                 


Ala Asp Gly Leu Ile Xaa Xaa Leu His Tyr Pro Ala Pro Lys Arg Asn 
225                 230                 235                 240 


Lys Pro Xaa Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met 
                245                 250                 255     


Glu Arg Xaa Asp Ile Xaa Met Lys His Lys Leu Gly Gly Gly Gln Tyr 
            260                 265                 270         


Gly Glu Val Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Xaa Val Ala 
        275                 280                 285             


Val Lys Xaa Leu Lys Glu Asp Xaa Met Glu Val Glu Glu Phe Leu Lys 
    290                 295                 300                 


Glu Ala Ala Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu 
305                 310                 315                 320 


Leu Gly Val Cys Xaa Arg Glu Pro Pro Phe Tyr Ile Ile Xaa Glu Phe 
                325                 330                 335     


Met Xaa Tyr Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln 
            340                 345                 350         


Glu Val Asn Ala Val Val Leu Leu Tyr Met Ala Xaa Gln Ile Ser Ser 
        355                 360                 365             


Ala Met Glu Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala 
    370                 375                 380                 


Ala Arg Asn Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp 
385                 390                 395                 400 


Phe Gly Leu Ser Arg Leu Met Xaa Gly Asp Xaa Tyr Xaa Ala His Ala 
                405                 410                 415     


Gly Ala Lys Phe Pro Ile Lys Trp Xaa Ala Pro Glu Ser Leu Ala Tyr 
            420                 425                 430         


Asn Lys Phe Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu 
        435                 440                 445             


Trp Glu Ile Ala Xaa Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu 
    450                 455                 460                 


Ser Gln Val Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro 
465                 470                 475                 480 


Glu Gly Cys Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln 
                485                 490                 495     


Trp Asn Pro Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe 
            500                 505                 510         


Glu Xaa Met Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu 
        515                 520                 525             


Leu Gly Lys Gln Gly Val Arg Gly Ala Val Ser Xaa Leu Leu Gln Ala 
    530                 535                 540                 


Pro Glu Leu Pro Xaa Lys Xaa Arg Xaa Ser Arg Arg Ala Ala Glu His 
545                 550                 555                 560 


Arg Asp Xaa Xaa Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly 
                565                 570                 575     


Glu Ser Asp Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro 
            580                 585                 590         


Arg Lys Glu Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg 
        595                 600                 605             


Leu Leu Pro Lys Asp Lys Lys Xaa Asn Leu Phe Ser Ala Leu Ile Lys 
    610                 615                 620                 


Lys Lys Lys Lys Xaa Ala Pro Xaa Pro Pro Lys Arg Ser Ser Ser Phe 
625                 630                 635                 640 


Arg Glu Met Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu 
                645                 650                 655     


Gly Arg Asp Ile Ser Asn Gly Ala Leu Ala Phe Xaa Pro Leu Asp Xaa 
            660                 665                 670         


Ala Asp Pro Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro 
        675                 680                 685             


Asn Gly Ala Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His 
    690                 695                 700                 


Leu Trp Lys Lys Ser Ser Xaa Leu Xaa Ser Ser Arg Leu Ala Xaa Gly 
705                 710                 715                 720 


Glu Glu Glu Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys 
                725                 730                 735     


Ser Ala Ser Cys Val Pro His Gly Ala Lys Asp Xaa Glu Trp Arg Ser 
            740                 745                 750         


Val Xaa Leu Pro Arg Asp Leu Gln Ser Xaa Gly Arg Gln Phe Asp Ser 
        755                 760                 765             


Ser Xaa Phe Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys 
    770                 775                 780                 


Arg Ala Gly Glu Asn Arg Ser Asp Gln Val Xaa Arg Gly Xaa Val Xaa 
785                 790                 795                 800 


Pro Pro Pro Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val 
                805                 810                 815     


Phe Lys Asp Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu 
            820                 825                 830         


Xaa Pro Lys Pro Leu Arg Arg Gln Val Xaa Val Ala Pro Ala Ser Gly 
        835                 840                 845             


Leu Pro His Lys Glu Glu Ala Gly Lys Gly Ser Ala Leu Gly Xaa Pro 
    850                 855                 860                 


Ala Ala Ala Glu Pro Val Xaa Pro Xaa Ser Lys Ala Gly Ser Gly Ala 
865                 870                 875                 880 


Pro Gly Gly Xaa Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg 
                885                 890                 895     


His Lys His Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser 
            900                 905                 910         


Arg Leu Lys Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys 
        915                 920                 925             


Ala Gly Gly Lys Pro Ser Gln Ser Pro Ser Gln Glu Ala Ala Gly Glu 
    930                 935                 940                 


Ala Val Leu Gly Ala Lys Xaa Lys Ala Xaa Ser Leu Val Asp Ala Val 
945                 950                 955                 960 


Asn Ser Asp Ala Ala Lys Pro Ser Gln Pro Gly Glu Gly Leu Lys Lys 
                965                 970                 975     


Pro Val Leu Pro Ala Xaa Pro Lys Pro Gln Ser Ala Lys Pro Ser Gly 
            980                 985                 990         


Xaa Pro Ile Ser Pro Ala Pro Val  Pro Ser Xaa Leu Pro  Ser Ala Ser 
        995                 1000                 1005             


Ser Ala  Leu Ala Gly Asp Gln  Pro Ser Ser Xaa Ala  Phe Ile Pro 
    1010                 1015                 1020             


Leu Ile  Ser Xaa Arg Val Ser  Leu Arg Lys Xaa Arg  Gln Pro Pro 
    1025                 1030                 1035             


Glu Arg  Ile Ala Ser Gly Ala  Ile Xaa Lys Gly Val  Val Leu Asp 
    1040                 1045                 1050             


Ser Xaa  Glu Ala Leu Cys Leu  Ala Ile Ser Arg Asn  Ser Glu Gln 
    1055                 1060                 1065             


Met Ala  Ser His Ser Ala Val  Leu Glu Ala Gly Lys  Asn Leu Tyr 
    1070                 1075                 1080             


Xaa Phe  Cys Val Ser Tyr Val  Asp Ser Ile Gln Gln  Met Arg Asn 
    1085                 1090                 1095             


Lys Phe  Ala Phe Arg Glu Ala  Ile Asn Lys Leu Glu  Asn Asn Leu 
    1100                 1105                 1110             


Arg Glu  Leu Gln Ile Cys Pro  Ala Xaa Ala Gly Ser  Gly Pro Ala 
    1115                 1120                 1125             


Ala Xaa  Gln Asp Phe Ser Lys  Leu Leu Ser Ser Val  Lys Glu Ile 
    1130                 1135                 1140             


Ser Asp  Ile Val Gln Arg 
    1145                 


<210> 1311
<211> 1130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1103)..(1103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<400> 1311
Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly 
1               5                   10                  15      


Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro 
            20                  25                  30          


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        35                  40                  45              


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    50                  55                  60                  


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Xaa Leu 
65                  70                  75                  80  


Ser Ile Xaa Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                85                  90                  95      


Gly Glu Trp Cys Glu Ala Gln Xaa Lys Asn Gly Gln Gly Trp Val Pro 
            100                 105                 110         


Ser Asn Tyr Ile Xaa Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        115                 120                 125             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser Ser Gly 
    130                 135                 140                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                165                 170                 175     


Asn Xaa Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            180                 185                 190         


Asn Xaa Leu Ala Glu Leu Val His His His Ser Xaa Val Ala Asp Gly 
        195                 200                 205             


Leu Ile Xaa Xaa Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Xaa 
    210                 215                 220                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Xaa 
225                 230                 235                 240 


Asp Ile Xaa Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val 
                245                 250                 255     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Xaa Val Ala Val Lys Xaa 
            260                 265                 270         


Leu Lys Glu Asp Xaa Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    290                 295                 300                 


Cys Xaa Arg Glu Pro Pro Phe Tyr Ile Ile Xaa Glu Phe Met Xaa Tyr 
305                 310                 315                 320 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                325                 330                 335     


Ala Val Val Leu Leu Tyr Met Ala Xaa Gln Ile Ser Ser Ala Met Glu 
            340                 345                 350         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        355                 360                 365             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    370                 375                 380                 


Ser Arg Leu Met Xaa Gly Asp Xaa Tyr Xaa Ala His Ala Gly Ala Lys 
385                 390                 395                 400 


Phe Pro Ile Lys Trp Xaa Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                405                 410                 415     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            420                 425                 430         


Ala Xaa Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val 
        435                 440                 445             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys 
    450                 455                 460                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
465                 470                 475                 480 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Xaa Met 
                485                 490                 495     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            500                 505                 510         


Gln Gly Val Arg Gly Ala Val Ser Xaa Leu Leu Gln Ala Pro Glu Leu 
        515                 520                 525             


Pro Xaa Lys Xaa Arg Xaa Ser Arg Arg Ala Ala Glu His Arg Asp Xaa 
    530                 535                 540                 


Xaa Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
545                 550                 555                 560 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                565                 570                 575     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            580                 585                 590         


Lys Asp Lys Lys Xaa Asn Leu Phe Ser Ala Leu Ile Lys Lys Lys Lys 
        595                 600                 605             


Lys Xaa Ala Pro Xaa Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met 
    610                 615                 620                 


Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly Arg Asp 
625                 630                 635                 640 


Ile Ser Asn Gly Ala Leu Ala Phe Xaa Pro Leu Asp Xaa Ala Asp Pro 
                645                 650                 655     


Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn Gly Ala 
            660                 665                 670         


Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu Trp Lys 
        675                 680                 685             


Lys Ser Ser Xaa Leu Xaa Ser Ser Arg Leu Ala Xaa Gly Glu Glu Glu 
    690                 695                 700                 


Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser Ala Ser 
705                 710                 715                 720 


Cys Val Pro His Gly Ala Lys Asp Xaa Glu Trp Arg Ser Val Xaa Leu 
                725                 730                 735     


Pro Arg Asp Leu Gln Ser Xaa Gly Arg Gln Phe Asp Ser Ser Xaa Phe 
            740                 745                 750         


Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg Ala Gly 
        755                 760                 765             


Glu Asn Arg Ser Asp Gln Val Xaa Arg Gly Xaa Val Xaa Pro Pro Pro 
    770                 775                 780                 


Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe Lys Asp 
785                 790                 795                 800 


Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Xaa Pro Lys 
                805                 810                 815     


Pro Leu Arg Arg Gln Val Xaa Val Ala Pro Ala Ser Gly Leu Pro His 
            820                 825                 830         


Lys Glu Glu Ala Gly Lys Gly Ser Ala Leu Gly Xaa Pro Ala Ala Ala 
        835                 840                 845             


Glu Pro Val Xaa Pro Xaa Ser Lys Ala Gly Ser Gly Ala Pro Gly Gly 
    850                 855                 860                 


Xaa Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His Lys His 
865                 870                 875                 880 


Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Arg Leu Lys 
                885                 890                 895     


Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala Gly Gly 
            900                 905                 910         


Lys Pro Ser Gln Ser Pro Ser Gln Glu Ala Ala Gly Glu Ala Val Leu 
        915                 920                 925             


Gly Ala Lys Xaa Lys Ala Xaa Ser Leu Val Asp Ala Val Asn Ser Asp 
    930                 935                 940                 


Ala Ala Lys Pro Ser Gln Pro Gly Glu Gly Leu Lys Lys Pro Val Leu 
945                 950                 955                 960 


Pro Ala Xaa Pro Lys Pro Gln Ser Ala Lys Pro Ser Gly Xaa Pro Ile 
                965                 970                 975     


Ser Pro Ala Pro Val Pro Ser Xaa Leu Pro Ser Ala Ser Ser Ala Leu 
            980                 985                 990         


Ala Gly Asp Gln Pro Ser Ser Xaa  Ala Phe Ile Pro Leu  Ile Ser Xaa 
        995                 1000                 1005             


Arg Val  Ser Leu Arg Lys Xaa  Arg Gln Pro Pro Glu  Arg Ile Ala 
    1010                 1015                 1020             


Ser Gly  Ala Ile Xaa Lys Gly  Val Val Leu Asp Ser  Xaa Glu Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ala Ile Ser Arg  Asn Ser Glu Gln Met  Ala Ser His 
    1040                 1045                 1050             


Ser Ala  Val Leu Glu Ala Gly  Lys Asn Leu Tyr Xaa  Phe Cys Val 
    1055                 1060                 1065             


Ser Tyr  Val Asp Ser Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe 
    1070                 1075                 1080             


Arg Glu  Ala Ile Asn Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln 
    1085                 1090                 1095             


Ile Cys  Pro Ala Xaa Ala Gly  Ser Gly Pro Ala Ala  Xaa Gln Asp 
    1100                 1105                 1110             


Phe Ser  Lys Leu Leu Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val 
    1115                 1120                 1125             


Gln Arg  
    1130 


<210> 1312
<211> 1079
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<400> 1312
Met Gly Gln Gln Val Gly Arg Val Gly Glu Ala Pro Gly Leu Gln Gln 
1               5                   10                  15      


Pro Gln Pro Arg Gly Ile Arg Gly Ser Ser Ala Ala Arg Pro Ser Gly 
            20                  25                  30          


Arg Arg Arg Asp Pro Ala Gly Arg Xaa Xaa Glu Xaa Gly Phe Asn Ile 
        35                  40                  45              


Phe Xaa Gln His Asp His Phe Ala Ser Cys Val Glu Asp Gly Phe Glu 
    50                  55                  60                  


Gly Asp Lys Xaa Gly Gly Ser Ser Pro Glu Ala Leu His Arg Pro Tyr 
65                  70                  75                  80  


Gly Cys Asp Val Glu Pro Gln Ala Leu Asn Glu Ala Ile Arg Trp Ser 
                85                  90                  95      


Ser Lys Glu Asn Leu Leu Gly Ala Xaa Glu Ser Asp Pro Asn Leu Phe 
            100                 105                 110         


Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Xaa Leu Ser Ile 
        115                 120                 125             


Xaa Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn Gln Asn Gly Glu 
    130                 135                 140                 


Trp Ser Glu Val Arg Ser Lys Asn Gly Gln Gly Trp Val Pro Ser Asn 
145                 150                 155                 160 


Tyr Ile Xaa Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr His Gly 
                165                 170                 175     


Pro Val Ser Arg Ser Ala Ala Glu Tyr Leu Leu Ser Ser Leu Ile Asn 
            180                 185                 190         


Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln Leu Ser 
        195                 200                 205             


Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile Asn Xaa 
    210                 215                 220                 


Xaa Ala Asp Gly Lys Val Tyr Val Xaa Ala Glu Ser Arg Phe Ser Xaa 
225                 230                 235                 240 


Leu Ala Glu Leu Val His His His Ser Xaa Val Ala Asp Gly Leu Val 
                245                 250                 255     


Xaa Xaa Leu His Tyr Pro Ala Pro Lys Cys Asn Lys Pro Xaa Val Tyr 
            260                 265                 270         


Gly Val Ser Pro Ile His Asp Lys Trp Glu Met Glu Arg Xaa Asp Ile 
        275                 280                 285             


Xaa Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr Val 
    290                 295                 300                 


Gly Val Trp Lys Lys Tyr Ser Leu Xaa Val Ala Val Lys Xaa Leu Lys 
305                 310                 315                 320 


Glu Asp Xaa Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala Val Met 
                325                 330                 335     


Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val Cys Xaa 
            340                 345                 350         


Leu Glu Pro Pro Phe Tyr Ile Val Xaa Glu Tyr Met Pro Tyr Gly Asn 
        355                 360                 365             


Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Glu Glu Val Xaa Ala Val 
    370                 375                 380                 


Val Leu Leu Tyr Met Ala Xaa Gln Ile Ser Ser Ala Met Glu Tyr Leu 
385                 390                 395                 400 


Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
                405                 410                 415     


Val Gly Glu Asn His Val Val Lys Val Ala Asp Phe Gly Leu Ser Arg 
            420                 425                 430         


Leu Met Xaa Gly Asp Xaa Tyr Xaa Ala His Ala Gly Ala Lys Phe Pro 
        435                 440                 445             


Ile Lys Trp Xaa Ala Pro Glu Ser Leu Ala Tyr Asn Xaa Phe Ser Ile 
    450                 455                 460                 


Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile Ala Xaa 
465                 470                 475                 480 


Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr Asp 
                485                 490                 495     


Leu Leu Glu Lys Gly Tyr Arg Met Glu Gln Pro Glu Gly Cys Pro Pro 
            500                 505                 510         


Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Lys Trp Ser Pro Ala Asp 
        515                 520                 525             


Arg Pro Ser Phe Ala Glu Xaa His Gln Ala Phe Glu Xaa Met Phe His 
    530                 535                 540                 


Asp Ser Ser Ile Ser Glu Glu Val Ala Glu Glu Leu Gly Arg Ala Ala 
545                 550                 555                 560 


Ser Ser Ser Ser Val Val Pro Tyr Leu Pro Arg Leu Pro Ile Leu Pro 
                565                 570                 575     


Ser Lys Xaa Arg Xaa Leu Lys Lys Gln Val Glu Asn Lys Glu Asn Ile 
            580                 585                 590         


Glu Gly Ala Gln Asp Ala Xaa Glu Asn Ser Ala Ser Ser Leu Ala Pro 
        595                 600                 605             


Gly Phe Ile Arg Gly Ala Gln Ala Ser Ser Gly Ser Pro Ala Leu Pro 
    610                 615                 620                 


Arg Lys Gln Arg Asp Lys Ser Pro Ser Ser Leu Leu Glu Asp Ala Lys 
625                 630                 635                 640 


Glu Xaa Cys Phe Xaa Arg Asp Arg Lys Gly Gly Phe Phe Ser Ser Phe 
                645                 650                 655     


Met Lys Lys Arg Asn Ala Pro Xaa Pro Pro Lys Arg Ser Ser Ser Phe 
            660                 665                 670         


Arg Glu Met Glu Asn Gln Pro His Lys Lys Tyr Glu Leu Xaa Gly Leu 
        675                 680                 685             


Pro Glu Gln Asp Arg Met Ala Met Xaa Leu Pro Arg Asn Cys Gln Arg 
    690                 695                 700                 


Ser Lys Leu Gln Leu Glu Arg Xaa Val Ser Xaa Ser Ser Gln Pro Glu 
705                 710                 715                 720 


Glu Asn Val Asp Arg Ala Asn Asp Met Leu Pro Lys Lys Ser Glu Glu 
                725                 730                 735     


Ser Ala Ala Pro Ser Arg Glu Arg Pro Lys Ala Lys Leu Leu Pro Arg 
            740                 745                 750         


Gly Ala Xaa Ala Leu Pro Leu Arg Xaa Pro Ser Gly Asp Leu Ala Ile 
        755                 760                 765             


Xaa Glu Lys Asp Pro Pro Gly Val Gly Val Ala Gly Val Ala Ala Ala 
    770                 775                 780                 


Pro Lys Gly Lys Glu Lys Asn Gly Gly Ala Arg Leu Gly Met Ala Gly 
785                 790                 795                 800 


Val Pro Glu Asp Gly Glu Gln Pro Gly Trp Pro Ser Pro Ala Lys Ala 
                805                 810                 815     


Ala Pro Val Leu Pro Xaa Xaa His Asn His Lys Val Pro Val Leu Ile 
            820                 825                 830         


Ser Pro Xaa Leu Lys His Xaa Pro Ala Asp Val Gln Leu Ile Gly Xaa 
        835                 840                 845             


Asp Ser Gln Gly Asn Lys Phe Lys Leu Leu Ser Glu His Gln Val Xaa 
    850                 855                 860                 


Ser Ser Gly Asp Lys Asp Arg Pro Arg Arg Val Lys Pro Lys Cys Ala 
865                 870                 875                 880 


Pro Pro Pro Pro Pro Val Met Arg Leu Leu Gln His Pro Ser Ile Cys 
                885                 890                 895     


Ser Asp Pro Xaa Glu Glu Pro Xaa Ala Leu Xaa Ala Gly Gln Ser Xaa 
            900                 905                 910         


Ser Glu Xaa Gln Glu Gly Gly Lys Lys Ala Ala Leu Gly Ala Val Pro 
        915                 920                 925             


Ile Ser Gly Lys Ala Gly Arg Pro Val Met Pro Pro Pro Gln Val Pro 
    930                 935                 940                 


Leu Pro Xaa Ser Ser Ile Ser Pro Ala Lys Met Ala Asn Gly Xaa Ala 
945                 950                 955                 960 


Gly Xaa Lys Val Ala Leu Arg Lys Xaa Lys Gln Ala Ala Glu Lys Ile 
                965                 970                 975     


Ser Ala Asp Lys Ile Ser Lys Glu Ala Leu Leu Glu Cys Ala Asp Leu 
            980                 985                 990         


Leu Ser Ser Ala Leu Xaa Glu Pro  Val Pro Asn Ser Gln  Leu Val Asp 
        995                 1000                 1005             


Xaa Gly  His Gln Leu Leu Asp  Tyr Cys Ser Gly Tyr  Val Asp Cys 
    1010                 1015                 1020             


Ile Pro  Gln Xaa Arg Asn Lys  Phe Ala Phe Arg Glu  Ala Val Ser 
    1025                 1030                 1035             


Lys Leu  Glu Leu Ser Leu Gln  Glu Leu Gln Val Ser  Ser Ala Ala 
    1040                 1045                 1050             


Ala Gly  Val Pro Gly Xaa Asn  Pro Val Leu Asn Asn  Leu Leu Ser 
    1055                 1060                 1065             


Cys Val  Gln Glu Ile Ser Asp  Val Val Gln Arg 
    1070                 1075                 


<210> 1313
<211> 1182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1007)..(1007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<400> 1313
Met Gly Gln Gln Val Gly Arg Val Gly Glu Ala Pro Gly Leu Gln Gln 
1               5                   10                  15      


Pro Gln Pro Arg Gly Ile Arg Gly Ser Ser Ala Ala Arg Pro Ser Gly 
            20                  25                  30          


Arg Arg Arg Asp Pro Ala Gly Arg Xaa Xaa Glu Xaa Gly Phe Asn Ile 
        35                  40                  45              


Phe Xaa Gln His Asp His Phe Ala Ser Cys Val Glu Asp Gly Phe Glu 
    50                  55                  60                  


Gly Asp Lys Xaa Gly Gly Ser Ser Pro Glu Ala Leu His Arg Pro Tyr 
65                  70                  75                  80  


Gly Cys Asp Val Glu Pro Gln Ala Leu Asn Glu Ala Ile Arg Trp Ser 
                85                  90                  95      


Ser Lys Glu Asn Leu Leu Gly Ala Xaa Glu Ser Asp Pro Asn Leu Phe 
            100                 105                 110         


Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Xaa Leu Ser Ile 
        115                 120                 125             


Xaa Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn Gln Asn Gly Glu 
    130                 135                 140                 


Trp Ser Glu Val Arg Ser Lys Asn Gly Gln Gly Trp Val Pro Ser Asn 
145                 150                 155                 160 


Tyr Ile Xaa Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr His Gly 
                165                 170                 175     


Pro Val Ser Arg Ser Ala Ala Glu Tyr Leu Leu Ser Ser Leu Ile Asn 
            180                 185                 190         


Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln Leu Ser 
        195                 200                 205             


Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile Asn Xaa 
    210                 215                 220                 


Xaa Ala Asp Gly Lys Val Tyr Val Xaa Ala Glu Ser Arg Phe Ser Xaa 
225                 230                 235                 240 


Leu Ala Glu Leu Val His His His Ser Xaa Val Ala Asp Gly Leu Val 
                245                 250                 255     


Xaa Xaa Leu His Tyr Pro Ala Pro Lys Cys Asn Lys Pro Xaa Val Tyr 
            260                 265                 270         


Gly Val Ser Pro Ile His Asp Lys Trp Glu Met Glu Arg Xaa Asp Ile 
        275                 280                 285             


Xaa Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr Val 
    290                 295                 300                 


Gly Val Trp Lys Lys Tyr Ser Leu Xaa Val Ala Val Lys Xaa Leu Lys 
305                 310                 315                 320 


Glu Asp Xaa Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala Val Met 
                325                 330                 335     


Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val Cys Xaa 
            340                 345                 350         


Leu Glu Pro Pro Phe Tyr Ile Val Xaa Glu Tyr Met Pro Tyr Gly Asn 
        355                 360                 365             


Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Glu Glu Val Xaa Ala Val 
    370                 375                 380                 


Val Leu Leu Tyr Met Ala Xaa Gln Ile Ser Ser Ala Met Glu Tyr Leu 
385                 390                 395                 400 


Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
                405                 410                 415     


Val Gly Glu Asn His Val Val Lys Val Ala Asp Phe Gly Leu Ser Arg 
            420                 425                 430         


Leu Met Xaa Gly Asp Xaa Tyr Xaa Ala His Ala Gly Ala Lys Phe Pro 
        435                 440                 445             


Ile Lys Trp Xaa Ala Pro Glu Ser Leu Ala Tyr Asn Xaa Phe Ser Ile 
    450                 455                 460                 


Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile Ala Xaa 
465                 470                 475                 480 


Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr Asp 
                485                 490                 495     


Leu Leu Glu Lys Gly Tyr Arg Met Glu Gln Pro Glu Gly Cys Pro Pro 
            500                 505                 510         


Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Lys Trp Ser Pro Ala Asp 
        515                 520                 525             


Arg Pro Ser Phe Ala Glu Xaa His Gln Ala Phe Glu Xaa Met Phe His 
    530                 535                 540                 


Asp Ser Ser Ile Ser Glu Glu Val Ala Glu Glu Leu Gly Arg Ala Ala 
545                 550                 555                 560 


Ser Ser Ser Ser Val Val Pro Tyr Leu Pro Arg Leu Pro Ile Leu Pro 
                565                 570                 575     


Ser Lys Xaa Arg Xaa Leu Lys Lys Gln Val Glu Asn Lys Glu Asn Ile 
            580                 585                 590         


Glu Gly Ala Gln Asp Ala Xaa Glu Asn Ser Ala Ser Ser Leu Ala Pro 
        595                 600                 605             


Gly Phe Ile Arg Gly Ala Gln Ala Ser Ser Gly Ser Pro Ala Leu Pro 
    610                 615                 620                 


Arg Lys Gln Arg Asp Lys Ser Pro Ser Ser Leu Leu Glu Asp Ala Lys 
625                 630                 635                 640 


Glu Xaa Cys Phe Xaa Arg Asp Arg Lys Gly Gly Phe Phe Ser Ser Phe 
                645                 650                 655     


Met Lys Lys Arg Asn Ala Pro Xaa Pro Pro Lys Arg Ser Ser Ser Phe 
            660                 665                 670         


Arg Glu Met Glu Asn Gln Pro His Lys Lys Tyr Glu Leu Xaa Gly Asn 
        675                 680                 685             


Phe Ser Ser Val Ala Ser Leu Gln His Ala Asp Gly Phe Ser Phe Xaa 
    690                 695                 700                 


Pro Ala Gln Gln Glu Ala Asn Leu Val Pro Pro Lys Cys Tyr Gly Gly 
705                 710                 715                 720 


Ser Phe Ala Gln Arg Asn Leu Cys Asn Asp Asp Gly Gly Gly Gly Gly 
                725                 730                 735     


Gly Ser Gly Xaa Ala Gly Gly Gly Trp Ser Gly Ile Xaa Gly Phe Phe 
            740                 745                 750         


Xaa Pro Arg Leu Ile Lys Lys Xaa Leu Gly Leu Arg Ala Gly Lys Pro 
        755                 760                 765             


Xaa Ala Ser Asp Asp Xaa Ser Lys Pro Phe Pro Arg Ser Asn Ser Xaa 
    770                 775                 780                 


Ser Ser Met Ser Ser Gly Leu Pro Glu Gln Asp Arg Met Ala Met Xaa 
785                 790                 795                 800 


Leu Pro Arg Asn Cys Gln Arg Ser Lys Leu Gln Leu Glu Arg Xaa Val 
                805                 810                 815     


Ser Xaa Ser Ser Gln Pro Glu Glu Asn Val Asp Arg Ala Asn Asp Met 
            820                 825                 830         


Leu Pro Lys Lys Ser Glu Glu Ser Ala Ala Pro Ser Arg Glu Arg Pro 
        835                 840                 845             


Lys Ala Lys Leu Leu Pro Arg Gly Ala Xaa Ala Leu Pro Leu Arg Xaa 
    850                 855                 860                 


Pro Ser Gly Asp Leu Ala Ile Xaa Glu Lys Asp Pro Pro Gly Val Gly 
865                 870                 875                 880 


Val Ala Gly Val Ala Ala Ala Pro Lys Gly Lys Glu Lys Asn Gly Gly 
                885                 890                 895     


Ala Arg Leu Gly Met Ala Gly Val Pro Glu Asp Gly Glu Gln Pro Gly 
            900                 905                 910         


Trp Pro Ser Pro Ala Lys Ala Ala Pro Val Leu Pro Xaa Xaa His Asn 
        915                 920                 925             


His Lys Val Pro Val Leu Ile Ser Pro Xaa Leu Lys His Xaa Pro Ala 
    930                 935                 940                 


Asp Val Gln Leu Ile Gly Xaa Asp Ser Gln Gly Asn Lys Phe Lys Leu 
945                 950                 955                 960 


Leu Ser Glu His Gln Val Xaa Ser Ser Gly Asp Lys Asp Arg Pro Arg 
                965                 970                 975     


Arg Val Lys Pro Lys Cys Ala Pro Pro Pro Pro Pro Val Met Arg Leu 
            980                 985                 990         


Leu Gln His Pro Ser Ile Cys Ser  Asp Pro Xaa Glu Glu  Pro Xaa Ala 
        995                 1000                 1005             


Leu Xaa  Ala Gly Gln Ser Xaa  Ser Glu Xaa Gln Glu  Gly Gly Lys 
    1010                 1015                 1020             


Lys Ala  Ala Leu Gly Ala Val  Pro Ile Ser Gly Lys  Ala Gly Arg 
    1025                 1030                 1035             


Pro Val  Met Pro Pro Pro Gln  Val Pro Leu Pro Xaa  Ser Ser Ile 
    1040                 1045                 1050             


Ser Pro  Ala Lys Met Ala Asn  Gly Xaa Ala Gly Xaa  Lys Val Ala 
    1055                 1060                 1065             


Leu Arg  Lys Xaa Lys Gln Ala  Ala Glu Lys Ile Ser  Ala Asp Lys 
    1070                 1075                 1080             


Ile Ser  Lys Glu Ala Leu Leu  Glu Cys Ala Asp Leu  Leu Ser Ser 
    1085                 1090                 1095             


Ala Leu  Xaa Glu Pro Val Pro  Asn Ser Gln Leu Val  Asp Xaa Gly 
    1100                 1105                 1110             


His Gln  Leu Leu Asp Tyr Cys  Ser Gly Tyr Val Asp  Cys Ile Pro 
    1115                 1120                 1125             


Gln Xaa  Arg Asn Lys Phe Ala  Phe Arg Glu Ala Val  Ser Lys Leu 
    1130                 1135                 1140             


Glu Leu  Ser Leu Gln Glu Leu  Gln Val Ser Ser Ala  Ala Ala Gly 
    1145                 1150                 1155             


Val Pro  Gly Xaa Asn Pro Val  Leu Asn Asn Leu Leu  Ser Cys Val 
    1160                 1165                 1170             


Gln Glu  Ile Ser Asp Val Val  Gln Arg 
    1175                 1180         


<210> 1314
<211> 542
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<400> 1314
Met Gly Gln Gln Val Gly Arg Val Gly Glu Ala Pro Gly Leu Gln Gln 
1               5                   10                  15      


Pro Gln Pro Arg Gly Ile Arg Gly Ser Ser Ala Ala Arg Pro Ser Gly 
            20                  25                  30          


Arg Arg Arg Asp Pro Ala Gly Arg Xaa Xaa Glu Xaa Gly Phe Asn Ile 
        35                  40                  45              


Phe Xaa Gln His Glu Ala Leu His Arg Pro Tyr Gly Cys Asp Val Glu 
    50                  55                  60                  


Pro Gln Ala Leu Asn Glu Ala Ile Arg Trp Ser Ser Lys Glu Asn Leu 
65                  70                  75                  80  


Leu Gly Ala Xaa Glu Ser Asp Pro Asn Leu Phe Val Ala Leu Tyr Asp 
                85                  90                  95      


Phe Val Ala Ser Gly Asp Asn Xaa Leu Ser Ile Xaa Lys Gly Glu Lys 
            100                 105                 110         


Leu Arg Val Leu Gly Tyr Asn Gln Asn Gly Glu Trp Ser Glu Val Arg 
        115                 120                 125             


Ser Lys Asn Gly Gln Gly Trp Val Pro Ser Asn Tyr Ile Xaa Pro Val 
    130                 135                 140                 


Asn Ser Leu Glu Lys His Ser Trp Tyr His Gly Pro Val Ser Arg Ser 
145                 150                 155                 160 


Ala Ala Glu Tyr Leu Leu Ser Ser Leu Ile Asn Gly Ser Phe Leu Val 
                165                 170                 175     


Arg Glu Ser Glu Ser Ser Pro Gly Gln Leu Ser Ile Ser Leu Arg Tyr 
            180                 185                 190         


Glu Gly Arg Val Tyr His Tyr Arg Ile Asn Xaa Xaa Ala Asp Gly Lys 
        195                 200                 205             


Val Tyr Val Xaa Ala Glu Ser Arg Phe Ser Xaa Leu Ala Glu Leu Val 
    210                 215                 220                 


His His His Ser Xaa Val Ala Asp Gly Leu Val Xaa Xaa Leu His Tyr 
225                 230                 235                 240 


Pro Ala Pro Lys Cys Asn Lys Pro Xaa Val Tyr Gly Val Ser Pro Ile 
                245                 250                 255     


His Asp Lys Trp Glu Met Glu Arg Xaa Asp Ile Xaa Met Lys His Lys 
            260                 265                 270         


Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr Val Gly Val Trp Lys Lys 
        275                 280                 285             


Tyr Ser Leu Xaa Val Ala Val Lys Xaa Leu Lys Glu Asp Xaa Met Glu 
    290                 295                 300                 


Val Glu Glu Phe Leu Lys Glu Ala Ala Val Met Lys Glu Ile Lys His 
305                 310                 315                 320 


Pro Asn Leu Val Gln Leu Leu Gly Val Cys Xaa Leu Glu Pro Pro Phe 
                325                 330                 335     


Tyr Ile Val Xaa Glu Tyr Met Pro Tyr Gly Asn Leu Leu Asp Tyr Leu 
            340                 345                 350         


Arg Glu Cys Asn Arg Glu Glu Val Xaa Ala Val Val Leu Leu Tyr Met 
        355                 360                 365             


Ala Xaa Gln Ile Ser Ser Ala Met Glu Tyr Leu Glu Lys Lys Asn Phe 
    370                 375                 380                 


Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Gly Glu Asn His 
385                 390                 395                 400 


Val Val Lys Val Ala Asp Phe Gly Leu Ser Arg Leu Met Xaa Gly Asp 
                405                 410                 415     


Xaa Tyr Xaa Ala His Ala Gly Ala Lys Phe Pro Ile Lys Trp Xaa Ala 
            420                 425                 430         


Pro Glu Ser Leu Ala Tyr Asn Xaa Phe Ser Ile Lys Ser Asp Val Trp 
        435                 440                 445             


Ala Phe Gly Val Leu Leu Trp Glu Ile Ala Xaa Tyr Gly Met Ser Pro 
    450                 455                 460                 


Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr Asp Leu Leu Glu Lys Gly 
465                 470                 475                 480 


Tyr Arg Met Glu Gln Pro Glu Gly Cys Pro Pro Lys Val Tyr Glu Leu 
                485                 490                 495     


Met Arg Ala Cys Trp Lys Trp Ser Pro Ala Asp Arg Pro Ser Phe Ala 
            500                 505                 510         


Glu Xaa His Gln Ala Phe Glu Xaa Met Phe His Asp Ser Ser Ile Ser 
        515                 520                 525             


Glu Val Leu Leu His Cys Ala Asn Gln Xaa Cys Ile Xaa Leu 
    530                 535                 540         


<210> 1315
<211> 1058
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<400> 1315
Met Gly Gln Gln Val Gly Arg Val Gly Glu Ala Pro Gly Leu Gln Gln 
1               5                   10                  15      


Pro Gln Pro Arg Gly Ile Arg Gly Ser Ser Ala Ala Arg Pro Ser Gly 
            20                  25                  30          


Arg Arg Arg Asp Pro Ala Gly Arg Xaa Xaa Glu Xaa Gly Phe Asn Ile 
        35                  40                  45              


Phe Xaa Gln His Glu Ala Leu His Arg Pro Tyr Gly Cys Asp Val Glu 
    50                  55                  60                  


Pro Gln Ala Leu Asn Glu Ala Ile Arg Trp Ser Ser Lys Glu Asn Leu 
65                  70                  75                  80  


Leu Gly Ala Xaa Glu Ser Asp Pro Asn Leu Phe Val Ala Leu Tyr Asp 
                85                  90                  95      


Phe Val Ala Ser Gly Asp Asn Xaa Leu Ser Ile Xaa Lys Gly Glu Lys 
            100                 105                 110         


Leu Arg Val Leu Gly Tyr Asn Gln Asn Gly Glu Trp Ser Glu Val Arg 
        115                 120                 125             


Ser Lys Asn Gly Gln Gly Trp Val Pro Ser Asn Tyr Ile Xaa Pro Val 
    130                 135                 140                 


Asn Ser Leu Glu Lys His Ser Trp Tyr His Gly Pro Val Ser Arg Ser 
145                 150                 155                 160 


Ala Ala Glu Tyr Leu Leu Ser Ser Leu Ile Asn Gly Ser Phe Leu Val 
                165                 170                 175     


Arg Glu Ser Glu Ser Ser Pro Gly Gln Leu Ser Ile Ser Leu Arg Tyr 
            180                 185                 190         


Glu Gly Arg Val Tyr His Tyr Arg Ile Asn Xaa Xaa Ala Asp Gly Lys 
        195                 200                 205             


Val Tyr Val Xaa Ala Glu Ser Arg Phe Ser Xaa Leu Ala Glu Leu Val 
    210                 215                 220                 


His His His Ser Xaa Val Ala Asp Gly Leu Val Xaa Xaa Leu His Tyr 
225                 230                 235                 240 


Pro Ala Pro Lys Cys Asn Lys Pro Xaa Val Tyr Gly Val Ser Pro Ile 
                245                 250                 255     


His Asp Lys Trp Glu Met Glu Arg Xaa Asp Ile Xaa Met Lys His Lys 
            260                 265                 270         


Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr Val Gly Val Trp Lys Lys 
        275                 280                 285             


Tyr Ser Leu Xaa Val Ala Val Lys Xaa Leu Lys Glu Asp Xaa Met Glu 
    290                 295                 300                 


Val Glu Glu Phe Leu Lys Glu Ala Ala Val Met Lys Glu Ile Lys His 
305                 310                 315                 320 


Pro Asn Leu Val Gln Leu Leu Gly Val Cys Xaa Leu Glu Pro Pro Phe 
                325                 330                 335     


Tyr Ile Val Xaa Glu Tyr Met Pro Tyr Gly Asn Leu Leu Asp Tyr Leu 
            340                 345                 350         


Arg Glu Cys Asn Arg Glu Glu Val Xaa Ala Val Val Leu Leu Tyr Met 
        355                 360                 365             


Ala Xaa Gln Ile Ser Ser Ala Met Glu Tyr Leu Glu Lys Lys Asn Phe 
    370                 375                 380                 


Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Gly Glu Asn His 
385                 390                 395                 400 


Val Val Lys Val Ala Asp Phe Gly Leu Ser Arg Leu Met Xaa Gly Asp 
                405                 410                 415     


Xaa Tyr Xaa Ala His Ala Gly Ala Lys Phe Pro Ile Lys Trp Xaa Ala 
            420                 425                 430         


Pro Glu Ser Leu Ala Tyr Asn Xaa Phe Ser Ile Lys Ser Asp Val Trp 
        435                 440                 445             


Ala Phe Gly Val Leu Leu Trp Glu Ile Ala Xaa Tyr Gly Met Ser Pro 
    450                 455                 460                 


Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr Asp Leu Leu Glu Lys Gly 
465                 470                 475                 480 


Tyr Arg Met Glu Gln Pro Glu Gly Cys Pro Pro Lys Val Tyr Glu Leu 
                485                 490                 495     


Met Arg Ala Cys Trp Lys Trp Ser Pro Ala Asp Arg Pro Ser Phe Ala 
            500                 505                 510         


Glu Xaa His Gln Ala Phe Glu Xaa Met Phe His Asp Ser Ser Ile Ser 
        515                 520                 525             


Glu Glu Val Ala Glu Glu Leu Gly Arg Ala Ala Ser Ser Ser Ser Val 
    530                 535                 540                 


Val Pro Tyr Leu Pro Arg Leu Pro Ile Leu Pro Ser Lys Xaa Arg Xaa 
545                 550                 555                 560 


Leu Lys Lys Gln Val Glu Asn Lys Glu Asn Ile Glu Gly Ala Gln Asp 
                565                 570                 575     


Ala Xaa Glu Asn Ser Ala Ser Ser Leu Ala Pro Gly Phe Ile Arg Gly 
            580                 585                 590         


Ala Gln Ala Ser Ser Gly Ser Pro Ala Leu Pro Arg Lys Gln Arg Asp 
        595                 600                 605             


Lys Ser Pro Ser Ser Leu Leu Glu Asp Ala Lys Glu Xaa Cys Phe Xaa 
    610                 615                 620                 


Arg Asp Arg Lys Gly Gly Phe Phe Ser Ser Phe Met Lys Lys Arg Asn 
625                 630                 635                 640 


Ala Pro Xaa Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met Glu Asn 
                645                 650                 655     


Gln Pro His Lys Lys Tyr Glu Leu Xaa Gly Leu Pro Glu Gln Asp Arg 
            660                 665                 670         


Met Ala Met Xaa Leu Pro Arg Asn Cys Gln Arg Ser Lys Leu Gln Leu 
        675                 680                 685             


Glu Arg Xaa Val Ser Xaa Ser Ser Gln Pro Glu Glu Asn Val Asp Arg 
    690                 695                 700                 


Ala Asn Asp Met Leu Pro Lys Lys Ser Glu Glu Ser Ala Ala Pro Ser 
705                 710                 715                 720 


Arg Glu Arg Pro Lys Ala Lys Leu Leu Pro Arg Gly Ala Xaa Ala Leu 
                725                 730                 735     


Pro Leu Arg Xaa Pro Ser Gly Asp Leu Ala Ile Xaa Glu Lys Asp Pro 
            740                 745                 750         


Pro Gly Val Gly Val Ala Gly Val Ala Ala Ala Pro Lys Gly Lys Glu 
        755                 760                 765             


Lys Asn Gly Gly Ala Arg Leu Gly Met Ala Gly Val Pro Glu Asp Gly 
    770                 775                 780                 


Glu Gln Pro Gly Trp Pro Ser Pro Ala Lys Ala Ala Pro Val Leu Pro 
785                 790                 795                 800 


Xaa Xaa His Asn His Lys Val Pro Val Leu Ile Ser Pro Xaa Leu Lys 
                805                 810                 815     


His Xaa Pro Ala Asp Val Gln Leu Ile Gly Xaa Asp Ser Gln Gly Asn 
            820                 825                 830         


Lys Phe Lys Leu Leu Ser Glu His Gln Val Xaa Ser Ser Gly Asp Lys 
        835                 840                 845             


Asp Arg Pro Arg Arg Val Lys Pro Lys Cys Ala Pro Pro Pro Pro Pro 
    850                 855                 860                 


Val Met Arg Leu Leu Gln His Pro Ser Ile Cys Ser Asp Pro Xaa Glu 
865                 870                 875                 880 


Glu Pro Xaa Ala Leu Xaa Ala Gly Gln Ser Xaa Ser Glu Xaa Gln Glu 
                885                 890                 895     


Gly Gly Lys Lys Ala Ala Leu Gly Ala Val Pro Ile Ser Gly Lys Ala 
            900                 905                 910         


Gly Arg Pro Val Met Pro Pro Pro Gln Val Pro Leu Pro Xaa Ser Ser 
        915                 920                 925             


Ile Ser Pro Ala Lys Met Ala Asn Gly Xaa Ala Gly Xaa Lys Val Ala 
    930                 935                 940                 


Leu Arg Lys Xaa Lys Gln Ala Ala Glu Lys Ile Ser Ala Asp Lys Ile 
945                 950                 955                 960 


Ser Lys Glu Ala Leu Leu Glu Cys Ala Asp Leu Leu Ser Ser Ala Leu 
                965                 970                 975     


Xaa Glu Pro Val Pro Asn Ser Gln Leu Val Asp Xaa Gly His Gln Leu 
            980                 985                 990         


Leu Asp Tyr Cys Ser Gly Tyr Val  Asp Cys Ile Pro Gln  Xaa Arg Asn 
        995                 1000                 1005             


Lys Phe  Ala Phe Arg Glu Ala  Val Ser Lys Leu Glu  Leu Ser Leu 
    1010                 1015                 1020             


Gln Glu  Leu Gln Val Ser Ser  Ala Ala Ala Gly Val  Pro Gly Xaa 
    1025                 1030                 1035             


Asn Pro  Val Leu Asn Asn Leu  Leu Ser Cys Val Gln  Glu Ile Ser 
    1040                 1045                 1050             


Asp Val  Val Gln Arg 
    1055             


<210> 1316
<211> 1161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1091)..(1091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<400> 1316
Met Gly Gln Gln Val Gly Arg Val Gly Glu Ala Pro Gly Leu Gln Gln 
1               5                   10                  15      


Pro Gln Pro Arg Gly Ile Arg Gly Ser Ser Ala Ala Arg Pro Ser Gly 
            20                  25                  30          


Arg Arg Arg Asp Pro Ala Gly Arg Xaa Xaa Glu Xaa Gly Phe Asn Ile 
        35                  40                  45              


Phe Xaa Gln His Glu Ala Leu His Arg Pro Tyr Gly Cys Asp Val Glu 
    50                  55                  60                  


Pro Gln Ala Leu Asn Glu Ala Ile Arg Trp Ser Ser Lys Glu Asn Leu 
65                  70                  75                  80  


Leu Gly Ala Xaa Glu Ser Asp Pro Asn Leu Phe Val Ala Leu Tyr Asp 
                85                  90                  95      


Phe Val Ala Ser Gly Asp Asn Xaa Leu Ser Ile Xaa Lys Gly Glu Lys 
            100                 105                 110         


Leu Arg Val Leu Gly Tyr Asn Gln Asn Gly Glu Trp Ser Glu Val Arg 
        115                 120                 125             


Ser Lys Asn Gly Gln Gly Trp Val Pro Ser Asn Tyr Ile Xaa Pro Val 
    130                 135                 140                 


Asn Ser Leu Glu Lys His Ser Trp Tyr His Gly Pro Val Ser Arg Ser 
145                 150                 155                 160 


Ala Ala Glu Tyr Leu Leu Ser Ser Leu Ile Asn Gly Ser Phe Leu Val 
                165                 170                 175     


Arg Glu Ser Glu Ser Ser Pro Gly Gln Leu Ser Ile Ser Leu Arg Tyr 
            180                 185                 190         


Glu Gly Arg Val Tyr His Tyr Arg Ile Asn Xaa Xaa Ala Asp Gly Lys 
        195                 200                 205             


Val Tyr Val Xaa Ala Glu Ser Arg Phe Ser Xaa Leu Ala Glu Leu Val 
    210                 215                 220                 


His His His Ser Xaa Val Ala Asp Gly Leu Val Xaa Xaa Leu His Tyr 
225                 230                 235                 240 


Pro Ala Pro Lys Cys Asn Lys Pro Xaa Val Tyr Gly Val Ser Pro Ile 
                245                 250                 255     


His Asp Lys Trp Glu Met Glu Arg Xaa Asp Ile Xaa Met Lys His Lys 
            260                 265                 270         


Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr Val Gly Val Trp Lys Lys 
        275                 280                 285             


Tyr Ser Leu Xaa Val Ala Val Lys Xaa Leu Lys Glu Asp Xaa Met Glu 
    290                 295                 300                 


Val Glu Glu Phe Leu Lys Glu Ala Ala Val Met Lys Glu Ile Lys His 
305                 310                 315                 320 


Pro Asn Leu Val Gln Leu Leu Gly Val Cys Xaa Leu Glu Pro Pro Phe 
                325                 330                 335     


Tyr Ile Val Xaa Glu Tyr Met Pro Tyr Gly Asn Leu Leu Asp Tyr Leu 
            340                 345                 350         


Arg Glu Cys Asn Arg Glu Glu Val Xaa Ala Val Val Leu Leu Tyr Met 
        355                 360                 365             


Ala Xaa Gln Ile Ser Ser Ala Met Glu Tyr Leu Glu Lys Lys Asn Phe 
    370                 375                 380                 


Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Gly Glu Asn His 
385                 390                 395                 400 


Val Val Lys Val Ala Asp Phe Gly Leu Ser Arg Leu Met Xaa Gly Asp 
                405                 410                 415     


Xaa Tyr Xaa Ala His Ala Gly Ala Lys Phe Pro Ile Lys Trp Xaa Ala 
            420                 425                 430         


Pro Glu Ser Leu Ala Tyr Asn Xaa Phe Ser Ile Lys Ser Asp Val Trp 
        435                 440                 445             


Ala Phe Gly Val Leu Leu Trp Glu Ile Ala Xaa Tyr Gly Met Ser Pro 
    450                 455                 460                 


Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr Asp Leu Leu Glu Lys Gly 
465                 470                 475                 480 


Tyr Arg Met Glu Gln Pro Glu Gly Cys Pro Pro Lys Val Tyr Glu Leu 
                485                 490                 495     


Met Arg Ala Cys Trp Lys Trp Ser Pro Ala Asp Arg Pro Ser Phe Ala 
            500                 505                 510         


Glu Xaa His Gln Ala Phe Glu Xaa Met Phe His Asp Ser Ser Ile Ser 
        515                 520                 525             


Glu Glu Val Ala Glu Glu Leu Gly Arg Ala Ala Ser Ser Ser Ser Val 
    530                 535                 540                 


Val Pro Tyr Leu Pro Arg Leu Pro Ile Leu Pro Ser Lys Xaa Arg Xaa 
545                 550                 555                 560 


Leu Lys Lys Gln Val Glu Asn Lys Glu Asn Ile Glu Gly Ala Gln Asp 
                565                 570                 575     


Ala Xaa Glu Asn Ser Ala Ser Ser Leu Ala Pro Gly Phe Ile Arg Gly 
            580                 585                 590         


Ala Gln Ala Ser Ser Gly Ser Pro Ala Leu Pro Arg Lys Gln Arg Asp 
        595                 600                 605             


Lys Ser Pro Ser Ser Leu Leu Glu Asp Ala Lys Glu Xaa Cys Phe Xaa 
    610                 615                 620                 


Arg Asp Arg Lys Gly Gly Phe Phe Ser Ser Phe Met Lys Lys Arg Asn 
625                 630                 635                 640 


Ala Pro Xaa Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met Glu Asn 
                645                 650                 655     


Gln Pro His Lys Lys Tyr Glu Leu Xaa Gly Asn Phe Ser Ser Val Ala 
            660                 665                 670         


Ser Leu Gln His Ala Asp Gly Phe Ser Phe Xaa Pro Ala Gln Gln Glu 
        675                 680                 685             


Ala Asn Leu Val Pro Pro Lys Cys Tyr Gly Gly Ser Phe Ala Gln Arg 
    690                 695                 700                 


Asn Leu Cys Asn Asp Asp Gly Gly Gly Gly Gly Gly Ser Gly Xaa Ala 
705                 710                 715                 720 


Gly Gly Gly Trp Ser Gly Ile Xaa Gly Phe Phe Xaa Pro Arg Leu Ile 
                725                 730                 735     


Lys Lys Xaa Leu Gly Leu Arg Ala Gly Lys Pro Xaa Ala Ser Asp Asp 
            740                 745                 750         


Xaa Ser Lys Pro Phe Pro Arg Ser Asn Ser Xaa Ser Ser Met Ser Ser 
        755                 760                 765             


Gly Leu Pro Glu Gln Asp Arg Met Ala Met Xaa Leu Pro Arg Asn Cys 
    770                 775                 780                 


Gln Arg Ser Lys Leu Gln Leu Glu Arg Xaa Val Ser Xaa Ser Ser Gln 
785                 790                 795                 800 


Pro Glu Glu Asn Val Asp Arg Ala Asn Asp Met Leu Pro Lys Lys Ser 
                805                 810                 815     


Glu Glu Ser Ala Ala Pro Ser Arg Glu Arg Pro Lys Ala Lys Leu Leu 
            820                 825                 830         


Pro Arg Gly Ala Xaa Ala Leu Pro Leu Arg Xaa Pro Ser Gly Asp Leu 
        835                 840                 845             


Ala Ile Xaa Glu Lys Asp Pro Pro Gly Val Gly Val Ala Gly Val Ala 
    850                 855                 860                 


Ala Ala Pro Lys Gly Lys Glu Lys Asn Gly Gly Ala Arg Leu Gly Met 
865                 870                 875                 880 


Ala Gly Val Pro Glu Asp Gly Glu Gln Pro Gly Trp Pro Ser Pro Ala 
                885                 890                 895     


Lys Ala Ala Pro Val Leu Pro Xaa Xaa His Asn His Lys Val Pro Val 
            900                 905                 910         


Leu Ile Ser Pro Xaa Leu Lys His Xaa Pro Ala Asp Val Gln Leu Ile 
        915                 920                 925             


Gly Xaa Asp Ser Gln Gly Asn Lys Phe Lys Leu Leu Ser Glu His Gln 
    930                 935                 940                 


Val Xaa Ser Ser Gly Asp Lys Asp Arg Pro Arg Arg Val Lys Pro Lys 
945                 950                 955                 960 


Cys Ala Pro Pro Pro Pro Pro Val Met Arg Leu Leu Gln His Pro Ser 
                965                 970                 975     


Ile Cys Ser Asp Pro Xaa Glu Glu Pro Xaa Ala Leu Xaa Ala Gly Gln 
            980                 985                 990         


Ser Xaa Ser Glu Xaa Gln Glu Gly  Gly Lys Lys Ala Ala  Leu Gly Ala 
        995                 1000                 1005             


Val Pro  Ile Ser Gly Lys Ala  Gly Arg Pro Val Met  Pro Pro Pro 
    1010                 1015                 1020             


Gln Val  Pro Leu Pro Xaa Ser  Ser Ile Ser Pro Ala  Lys Met Ala 
    1025                 1030                 1035             


Asn Gly  Xaa Ala Gly Xaa Lys  Val Ala Leu Arg Lys  Xaa Lys Gln 
    1040                 1045                 1050             


Ala Ala  Glu Lys Ile Ser Ala  Asp Lys Ile Ser Lys  Glu Ala Leu 
    1055                 1060                 1065             


Leu Glu  Cys Ala Asp Leu Leu  Ser Ser Ala Leu Xaa  Glu Pro Val 
    1070                 1075                 1080             


Pro Asn  Ser Gln Leu Val Asp  Xaa Gly His Gln Leu  Leu Asp Tyr 
    1085                 1090                 1095             


Cys Ser  Gly Tyr Val Asp Cys  Ile Pro Gln Xaa Arg  Asn Lys Phe 
    1100                 1105                 1110             


Ala Phe  Arg Glu Ala Val Ser  Lys Leu Glu Leu Ser  Leu Gln Glu 
    1115                 1120                 1125             


Leu Gln  Val Ser Ser Ala Ala  Ala Gly Val Pro Gly  Xaa Asn Pro 
    1130                 1135                 1140             


Val Leu  Asn Asn Leu Leu Ser  Cys Val Gln Glu Ile  Ser Asp Val 
    1145                 1150                 1155             


Val Gln  Arg 
    1160     


<210> 1317
<211> 1064
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (983)..(983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<400> 1317
Met Val Leu Gly Xaa Val Leu Leu Pro Pro Asn Ser Tyr Gly Arg Asp 
1               5                   10                  15      


Gln Asp Xaa Ser Leu Cys Cys Leu Cys Xaa Glu Ala Ser Glu Ser Ala 
            20                  25                  30          


Leu Pro Asp Leu Xaa Asp His Phe Ala Ser Cys Val Glu Asp Gly Phe 
        35                  40                  45              


Glu Gly Asp Lys Xaa Gly Gly Ser Ser Pro Glu Ala Leu His Arg Pro 
    50                  55                  60                  


Tyr Gly Cys Asp Val Glu Pro Gln Ala Leu Asn Glu Ala Ile Arg Trp 
65                  70                  75                  80  


Ser Ser Lys Glu Asn Leu Leu Gly Ala Xaa Glu Ser Asp Pro Asn Leu 
                85                  90                  95      


Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Xaa Leu Ser 
            100                 105                 110         


Ile Xaa Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn Gln Asn Gly 
        115                 120                 125             


Glu Trp Ser Glu Val Arg Ser Lys Asn Gly Gln Gly Trp Val Pro Ser 
    130                 135                 140                 


Asn Tyr Ile Xaa Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr His 
145                 150                 155                 160 


Gly Pro Val Ser Arg Ser Ala Ala Glu Tyr Leu Leu Ser Ser Leu Ile 
                165                 170                 175     


Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln Leu 
            180                 185                 190         


Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile Asn 
        195                 200                 205             


Xaa Xaa Ala Asp Gly Lys Val Tyr Val Xaa Ala Glu Ser Arg Phe Ser 
    210                 215                 220                 


Xaa Leu Ala Glu Leu Val His His His Ser Xaa Val Ala Asp Gly Leu 
225                 230                 235                 240 


Val Xaa Xaa Leu His Tyr Pro Ala Pro Lys Cys Asn Lys Pro Xaa Val 
                245                 250                 255     


Tyr Gly Val Ser Pro Ile His Asp Lys Trp Glu Met Glu Arg Xaa Asp 
            260                 265                 270         


Ile Xaa Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr 
        275                 280                 285             


Val Gly Val Trp Lys Lys Tyr Ser Leu Xaa Val Ala Val Lys Xaa Leu 
    290                 295                 300                 


Lys Glu Asp Xaa Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala Val 
305                 310                 315                 320 


Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val Cys 
                325                 330                 335     


Xaa Leu Glu Pro Pro Phe Tyr Ile Val Xaa Glu Tyr Met Pro Tyr Gly 
            340                 345                 350         


Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Glu Glu Val Xaa Ala 
        355                 360                 365             


Val Val Leu Leu Tyr Met Ala Xaa Gln Ile Ser Ser Ala Met Glu Tyr 
    370                 375                 380                 


Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys 
385                 390                 395                 400 


Leu Val Gly Glu Asn His Val Val Lys Val Ala Asp Phe Gly Leu Ser 
                405                 410                 415     


Arg Leu Met Xaa Gly Asp Xaa Tyr Xaa Ala His Ala Gly Ala Lys Phe 
            420                 425                 430         


Pro Ile Lys Trp Xaa Ala Pro Glu Ser Leu Ala Tyr Asn Xaa Phe Ser 
        435                 440                 445             


Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile Ala 
    450                 455                 460                 


Xaa Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr 
465                 470                 475                 480 


Asp Leu Leu Glu Lys Gly Tyr Arg Met Glu Gln Pro Glu Gly Cys Pro 
                485                 490                 495     


Pro Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Lys Trp Ser Pro Ala 
            500                 505                 510         


Asp Arg Pro Ser Phe Ala Glu Xaa His Gln Ala Phe Glu Xaa Met Phe 
        515                 520                 525             


His Asp Ser Ser Ile Ser Glu Glu Val Ala Glu Glu Leu Gly Arg Ala 
    530                 535                 540                 


Ala Ser Ser Ser Ser Val Val Pro Tyr Leu Pro Arg Leu Pro Ile Leu 
545                 550                 555                 560 


Pro Ser Lys Xaa Arg Xaa Leu Lys Lys Gln Val Glu Asn Lys Glu Asn 
                565                 570                 575     


Ile Glu Gly Ala Gln Asp Ala Xaa Glu Asn Ser Ala Ser Ser Leu Ala 
            580                 585                 590         


Pro Gly Phe Ile Arg Gly Ala Gln Ala Ser Ser Gly Ser Pro Ala Leu 
        595                 600                 605             


Pro Arg Lys Gln Arg Asp Lys Ser Pro Ser Ser Leu Leu Glu Asp Ala 
    610                 615                 620                 


Lys Glu Xaa Cys Phe Xaa Arg Asp Arg Lys Gly Gly Phe Phe Ser Ser 
625                 630                 635                 640 


Phe Met Lys Lys Arg Asn Ala Pro Xaa Pro Pro Lys Arg Ser Ser Ser 
                645                 650                 655     


Phe Arg Glu Met Glu Asn Gln Pro His Lys Lys Tyr Glu Leu Xaa Gly 
            660                 665                 670         


Leu Pro Glu Gln Asp Arg Met Ala Met Xaa Leu Pro Arg Asn Cys Gln 
        675                 680                 685             


Arg Ser Lys Leu Gln Leu Glu Arg Xaa Val Ser Xaa Ser Ser Gln Pro 
    690                 695                 700                 


Glu Glu Asn Val Asp Arg Ala Asn Asp Met Leu Pro Lys Lys Ser Glu 
705                 710                 715                 720 


Glu Ser Ala Ala Pro Ser Arg Glu Arg Pro Lys Ala Lys Leu Leu Pro 
                725                 730                 735     


Arg Gly Ala Xaa Ala Leu Pro Leu Arg Xaa Pro Ser Gly Asp Leu Ala 
            740                 745                 750         


Ile Xaa Glu Lys Asp Pro Pro Gly Val Gly Val Ala Gly Val Ala Ala 
        755                 760                 765             


Ala Pro Lys Gly Lys Glu Lys Asn Gly Gly Ala Arg Leu Gly Met Ala 
    770                 775                 780                 


Gly Val Pro Glu Asp Gly Glu Gln Pro Gly Trp Pro Ser Pro Ala Lys 
785                 790                 795                 800 


Ala Ala Pro Val Leu Pro Xaa Xaa His Asn His Lys Val Pro Val Leu 
                805                 810                 815     


Ile Ser Pro Xaa Leu Lys His Xaa Pro Ala Asp Val Gln Leu Ile Gly 
            820                 825                 830         


Xaa Asp Ser Gln Gly Asn Lys Phe Lys Leu Leu Ser Glu His Gln Val 
        835                 840                 845             


Xaa Ser Ser Gly Asp Lys Asp Arg Pro Arg Arg Val Lys Pro Lys Cys 
    850                 855                 860                 


Ala Pro Pro Pro Pro Pro Val Met Arg Leu Leu Gln His Pro Ser Ile 
865                 870                 875                 880 


Cys Ser Asp Pro Xaa Glu Glu Pro Xaa Ala Leu Xaa Ala Gly Gln Ser 
                885                 890                 895     


Xaa Ser Glu Xaa Gln Glu Gly Gly Lys Lys Ala Ala Leu Gly Ala Val 
            900                 905                 910         


Pro Ile Ser Gly Lys Ala Gly Arg Pro Val Met Pro Pro Pro Gln Val 
        915                 920                 925             


Pro Leu Pro Xaa Ser Ser Ile Ser Pro Ala Lys Met Ala Asn Gly Xaa 
    930                 935                 940                 


Ala Gly Xaa Lys Val Ala Leu Arg Lys Xaa Lys Gln Ala Ala Glu Lys 
945                 950                 955                 960 


Ile Ser Ala Asp Lys Ile Ser Lys Glu Ala Leu Leu Glu Cys Ala Asp 
                965                 970                 975     


Leu Leu Ser Ser Ala Leu Xaa Glu Pro Val Pro Asn Ser Gln Leu Val 
            980                 985                 990         


Asp Xaa Gly His Gln Leu Leu Asp  Tyr Cys Ser Gly Tyr  Val Asp Cys 
        995                 1000                 1005             


Ile Pro  Gln Xaa Arg Asn Lys  Phe Ala Phe Arg Glu  Ala Val Ser 
    1010                 1015                 1020             


Lys Leu  Glu Leu Ser Leu Gln  Glu Leu Gln Val Ser  Ser Ala Ala 
    1025                 1030                 1035             


Ala Gly  Val Pro Gly Xaa Asn  Pro Val Leu Asn Asn  Leu Leu Ser 
    1040                 1045                 1050             


Cys Val  Gln Glu Ile Ser Asp  Val Val Gln Arg 
    1055                 1060                 


<210> 1318
<211> 1167
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<400> 1318
Met Val Leu Gly Xaa Val Leu Leu Pro Pro Asn Ser Tyr Gly Arg Asp 
1               5                   10                  15      


Gln Asp Xaa Ser Leu Cys Cys Leu Cys Xaa Glu Ala Ser Glu Ser Ala 
            20                  25                  30          


Leu Pro Asp Leu Xaa Asp His Phe Ala Ser Cys Val Glu Asp Gly Phe 
        35                  40                  45              


Glu Gly Asp Lys Xaa Gly Gly Ser Ser Pro Glu Ala Leu His Arg Pro 
    50                  55                  60                  


Tyr Gly Cys Asp Val Glu Pro Gln Ala Leu Asn Glu Ala Ile Arg Trp 
65                  70                  75                  80  


Ser Ser Lys Glu Asn Leu Leu Gly Ala Xaa Glu Ser Asp Pro Asn Leu 
                85                  90                  95      


Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Xaa Leu Ser 
            100                 105                 110         


Ile Xaa Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn Gln Asn Gly 
        115                 120                 125             


Glu Trp Ser Glu Val Arg Ser Lys Asn Gly Gln Gly Trp Val Pro Ser 
    130                 135                 140                 


Asn Tyr Ile Xaa Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr His 
145                 150                 155                 160 


Gly Pro Val Ser Arg Ser Ala Ala Glu Tyr Leu Leu Ser Ser Leu Ile 
                165                 170                 175     


Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln Leu 
            180                 185                 190         


Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile Asn 
        195                 200                 205             


Xaa Xaa Ala Asp Gly Lys Val Tyr Val Xaa Ala Glu Ser Arg Phe Ser 
    210                 215                 220                 


Xaa Leu Ala Glu Leu Val His His His Ser Xaa Val Ala Asp Gly Leu 
225                 230                 235                 240 


Val Xaa Xaa Leu His Tyr Pro Ala Pro Lys Cys Asn Lys Pro Xaa Val 
                245                 250                 255     


Tyr Gly Val Ser Pro Ile His Asp Lys Trp Glu Met Glu Arg Xaa Asp 
            260                 265                 270         


Ile Xaa Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr 
        275                 280                 285             


Val Gly Val Trp Lys Lys Tyr Ser Leu Xaa Val Ala Val Lys Xaa Leu 
    290                 295                 300                 


Lys Glu Asp Xaa Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala Val 
305                 310                 315                 320 


Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val Cys 
                325                 330                 335     


Xaa Leu Glu Pro Pro Phe Tyr Ile Val Xaa Glu Tyr Met Pro Tyr Gly 
            340                 345                 350         


Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Glu Glu Val Xaa Ala 
        355                 360                 365             


Val Val Leu Leu Tyr Met Ala Xaa Gln Ile Ser Ser Ala Met Glu Tyr 
    370                 375                 380                 


Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys 
385                 390                 395                 400 


Leu Val Gly Glu Asn His Val Val Lys Val Ala Asp Phe Gly Leu Ser 
                405                 410                 415     


Arg Leu Met Xaa Gly Asp Xaa Tyr Xaa Ala His Ala Gly Ala Lys Phe 
            420                 425                 430         


Pro Ile Lys Trp Xaa Ala Pro Glu Ser Leu Ala Tyr Asn Xaa Phe Ser 
        435                 440                 445             


Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile Ala 
    450                 455                 460                 


Xaa Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr 
465                 470                 475                 480 


Asp Leu Leu Glu Lys Gly Tyr Arg Met Glu Gln Pro Glu Gly Cys Pro 
                485                 490                 495     


Pro Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Lys Trp Ser Pro Ala 
            500                 505                 510         


Asp Arg Pro Ser Phe Ala Glu Xaa His Gln Ala Phe Glu Xaa Met Phe 
        515                 520                 525             


His Asp Ser Ser Ile Ser Glu Glu Val Ala Glu Glu Leu Gly Arg Ala 
    530                 535                 540                 


Ala Ser Ser Ser Ser Val Val Pro Tyr Leu Pro Arg Leu Pro Ile Leu 
545                 550                 555                 560 


Pro Ser Lys Xaa Arg Xaa Leu Lys Lys Gln Val Glu Asn Lys Glu Asn 
                565                 570                 575     


Ile Glu Gly Ala Gln Asp Ala Xaa Glu Asn Ser Ala Ser Ser Leu Ala 
            580                 585                 590         


Pro Gly Phe Ile Arg Gly Ala Gln Ala Ser Ser Gly Ser Pro Ala Leu 
        595                 600                 605             


Pro Arg Lys Gln Arg Asp Lys Ser Pro Ser Ser Leu Leu Glu Asp Ala 
    610                 615                 620                 


Lys Glu Xaa Cys Phe Xaa Arg Asp Arg Lys Gly Gly Phe Phe Ser Ser 
625                 630                 635                 640 


Phe Met Lys Lys Arg Asn Ala Pro Xaa Pro Pro Lys Arg Ser Ser Ser 
                645                 650                 655     


Phe Arg Glu Met Glu Asn Gln Pro His Lys Lys Tyr Glu Leu Xaa Gly 
            660                 665                 670         


Asn Phe Ser Ser Val Ala Ser Leu Gln His Ala Asp Gly Phe Ser Phe 
        675                 680                 685             


Xaa Pro Ala Gln Gln Glu Ala Asn Leu Val Pro Pro Lys Cys Tyr Gly 
    690                 695                 700                 


Gly Ser Phe Ala Gln Arg Asn Leu Cys Asn Asp Asp Gly Gly Gly Gly 
705                 710                 715                 720 


Gly Gly Ser Gly Xaa Ala Gly Gly Gly Trp Ser Gly Ile Xaa Gly Phe 
                725                 730                 735     


Phe Xaa Pro Arg Leu Ile Lys Lys Xaa Leu Gly Leu Arg Ala Gly Lys 
            740                 745                 750         


Pro Xaa Ala Ser Asp Asp Xaa Ser Lys Pro Phe Pro Arg Ser Asn Ser 
        755                 760                 765             


Xaa Ser Ser Met Ser Ser Gly Leu Pro Glu Gln Asp Arg Met Ala Met 
    770                 775                 780                 


Xaa Leu Pro Arg Asn Cys Gln Arg Ser Lys Leu Gln Leu Glu Arg Xaa 
785                 790                 795                 800 


Val Ser Xaa Ser Ser Gln Pro Glu Glu Asn Val Asp Arg Ala Asn Asp 
                805                 810                 815     


Met Leu Pro Lys Lys Ser Glu Glu Ser Ala Ala Pro Ser Arg Glu Arg 
            820                 825                 830         


Pro Lys Ala Lys Leu Leu Pro Arg Gly Ala Xaa Ala Leu Pro Leu Arg 
        835                 840                 845             


Xaa Pro Ser Gly Asp Leu Ala Ile Xaa Glu Lys Asp Pro Pro Gly Val 
    850                 855                 860                 


Gly Val Ala Gly Val Ala Ala Ala Pro Lys Gly Lys Glu Lys Asn Gly 
865                 870                 875                 880 


Gly Ala Arg Leu Gly Met Ala Gly Val Pro Glu Asp Gly Glu Gln Pro 
                885                 890                 895     


Gly Trp Pro Ser Pro Ala Lys Ala Ala Pro Val Leu Pro Xaa Xaa His 
            900                 905                 910         


Asn His Lys Val Pro Val Leu Ile Ser Pro Xaa Leu Lys His Xaa Pro 
        915                 920                 925             


Ala Asp Val Gln Leu Ile Gly Xaa Asp Ser Gln Gly Asn Lys Phe Lys 
    930                 935                 940                 


Leu Leu Ser Glu His Gln Val Xaa Ser Ser Gly Asp Lys Asp Arg Pro 
945                 950                 955                 960 


Arg Arg Val Lys Pro Lys Cys Ala Pro Pro Pro Pro Pro Val Met Arg 
                965                 970                 975     


Leu Leu Gln His Pro Ser Ile Cys Ser Asp Pro Xaa Glu Glu Pro Xaa 
            980                 985                 990         


Ala Leu Xaa Ala Gly Gln Ser Xaa  Ser Glu Xaa Gln Glu  Gly Gly Lys 
        995                 1000                 1005             


Lys Ala  Ala Leu Gly Ala Val  Pro Ile Ser Gly Lys  Ala Gly Arg 
    1010                 1015                 1020             


Pro Val  Met Pro Pro Pro Gln  Val Pro Leu Pro Xaa  Ser Ser Ile 
    1025                 1030                 1035             


Ser Pro  Ala Lys Met Ala Asn  Gly Xaa Ala Gly Xaa  Lys Val Ala 
    1040                 1045                 1050             


Leu Arg  Lys Xaa Lys Gln Ala  Ala Glu Lys Ile Ser  Ala Asp Lys 
    1055                 1060                 1065             


Ile Ser  Lys Glu Ala Leu Leu  Glu Cys Ala Asp Leu  Leu Ser Ser 
    1070                 1075                 1080             


Ala Leu  Xaa Glu Pro Val Pro  Asn Ser Gln Leu Val  Asp Xaa Gly 
    1085                 1090                 1095             


His Gln  Leu Leu Asp Tyr Cys  Ser Gly Tyr Val Asp  Cys Ile Pro 
    1100                 1105                 1110             


Gln Xaa  Arg Asn Lys Phe Ala  Phe Arg Glu Ala Val  Ser Lys Leu 
    1115                 1120                 1125             


Glu Leu  Ser Leu Gln Glu Leu  Gln Val Ser Ser Ala  Ala Ala Gly 
    1130                 1135                 1140             


Val Pro  Gly Xaa Asn Pro Val  Leu Asn Asn Leu Leu  Ser Cys Val 
    1145                 1150                 1155             


Gln Glu  Ile Ser Asp Val Val  Gln Arg 
    1160                 1165         


<210> 1319
<211> 1043
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<400> 1319
Met Val Leu Gly Xaa Val Leu Leu Pro Pro Asn Ser Tyr Gly Arg Asp 
1               5                   10                  15      


Gln Asp Xaa Ser Leu Cys Cys Leu Cys Xaa Glu Ala Ser Glu Ser Ala 
            20                  25                  30          


Leu Pro Asp Leu Xaa Glu Ala Leu His Arg Pro Tyr Gly Cys Asp Val 
        35                  40                  45              


Glu Pro Gln Ala Leu Asn Glu Ala Ile Arg Trp Ser Ser Lys Glu Asn 
    50                  55                  60                  


Leu Leu Gly Ala Xaa Glu Ser Asp Pro Asn Leu Phe Val Ala Leu Tyr 
65                  70                  75                  80  


Asp Phe Val Ala Ser Gly Asp Asn Xaa Leu Ser Ile Xaa Lys Gly Glu 
                85                  90                  95      


Lys Leu Arg Val Leu Gly Tyr Asn Gln Asn Gly Glu Trp Ser Glu Val 
            100                 105                 110         


Arg Ser Lys Asn Gly Gln Gly Trp Val Pro Ser Asn Tyr Ile Xaa Pro 
        115                 120                 125             


Val Asn Ser Leu Glu Lys His Ser Trp Tyr His Gly Pro Val Ser Arg 
    130                 135                 140                 


Ser Ala Ala Glu Tyr Leu Leu Ser Ser Leu Ile Asn Gly Ser Phe Leu 
145                 150                 155                 160 


Val Arg Glu Ser Glu Ser Ser Pro Gly Gln Leu Ser Ile Ser Leu Arg 
                165                 170                 175     


Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile Asn Xaa Xaa Ala Asp Gly 
            180                 185                 190         


Lys Val Tyr Val Xaa Ala Glu Ser Arg Phe Ser Xaa Leu Ala Glu Leu 
        195                 200                 205             


Val His His His Ser Xaa Val Ala Asp Gly Leu Val Xaa Xaa Leu His 
    210                 215                 220                 


Tyr Pro Ala Pro Lys Cys Asn Lys Pro Xaa Val Tyr Gly Val Ser Pro 
225                 230                 235                 240 


Ile His Asp Lys Trp Glu Met Glu Arg Xaa Asp Ile Xaa Met Lys His 
                245                 250                 255     


Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr Val Gly Val Trp Lys 
            260                 265                 270         


Lys Tyr Ser Leu Xaa Val Ala Val Lys Xaa Leu Lys Glu Asp Xaa Met 
        275                 280                 285             


Glu Val Glu Glu Phe Leu Lys Glu Ala Ala Val Met Lys Glu Ile Lys 
    290                 295                 300                 


His Pro Asn Leu Val Gln Leu Leu Gly Val Cys Xaa Leu Glu Pro Pro 
305                 310                 315                 320 


Phe Tyr Ile Val Xaa Glu Tyr Met Pro Tyr Gly Asn Leu Leu Asp Tyr 
                325                 330                 335     


Leu Arg Glu Cys Asn Arg Glu Glu Val Xaa Ala Val Val Leu Leu Tyr 
            340                 345                 350         


Met Ala Xaa Gln Ile Ser Ser Ala Met Glu Tyr Leu Glu Lys Lys Asn 
        355                 360                 365             


Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Gly Glu Asn 
    370                 375                 380                 


His Val Val Lys Val Ala Asp Phe Gly Leu Ser Arg Leu Met Xaa Gly 
385                 390                 395                 400 


Asp Xaa Tyr Xaa Ala His Ala Gly Ala Lys Phe Pro Ile Lys Trp Xaa 
                405                 410                 415     


Ala Pro Glu Ser Leu Ala Tyr Asn Xaa Phe Ser Ile Lys Ser Asp Val 
            420                 425                 430         


Trp Ala Phe Gly Val Leu Leu Trp Glu Ile Ala Xaa Tyr Gly Met Ser 
        435                 440                 445             


Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr Asp Leu Leu Glu Lys 
    450                 455                 460                 


Gly Tyr Arg Met Glu Gln Pro Glu Gly Cys Pro Pro Lys Val Tyr Glu 
465                 470                 475                 480 


Leu Met Arg Ala Cys Trp Lys Trp Ser Pro Ala Asp Arg Pro Ser Phe 
                485                 490                 495     


Ala Glu Xaa His Gln Ala Phe Glu Xaa Met Phe His Asp Ser Ser Ile 
            500                 505                 510         


Ser Glu Glu Val Ala Glu Glu Leu Gly Arg Ala Ala Ser Ser Ser Ser 
        515                 520                 525             


Val Val Pro Tyr Leu Pro Arg Leu Pro Ile Leu Pro Ser Lys Xaa Arg 
    530                 535                 540                 


Xaa Leu Lys Lys Gln Val Glu Asn Lys Glu Asn Ile Glu Gly Ala Gln 
545                 550                 555                 560 


Asp Ala Xaa Glu Asn Ser Ala Ser Ser Leu Ala Pro Gly Phe Ile Arg 
                565                 570                 575     


Gly Ala Gln Ala Ser Ser Gly Ser Pro Ala Leu Pro Arg Lys Gln Arg 
            580                 585                 590         


Asp Lys Ser Pro Ser Ser Leu Leu Glu Asp Ala Lys Glu Xaa Cys Phe 
        595                 600                 605             


Xaa Arg Asp Arg Lys Gly Gly Phe Phe Ser Ser Phe Met Lys Lys Arg 
    610                 615                 620                 


Asn Ala Pro Xaa Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met Glu 
625                 630                 635                 640 


Asn Gln Pro His Lys Lys Tyr Glu Leu Xaa Gly Leu Pro Glu Gln Asp 
                645                 650                 655     


Arg Met Ala Met Xaa Leu Pro Arg Asn Cys Gln Arg Ser Lys Leu Gln 
            660                 665                 670         


Leu Glu Arg Xaa Val Ser Xaa Ser Ser Gln Pro Glu Glu Asn Val Asp 
        675                 680                 685             


Arg Ala Asn Asp Met Leu Pro Lys Lys Ser Glu Glu Ser Ala Ala Pro 
    690                 695                 700                 


Ser Arg Glu Arg Pro Lys Ala Lys Leu Leu Pro Arg Gly Ala Xaa Ala 
705                 710                 715                 720 


Leu Pro Leu Arg Xaa Pro Ser Gly Asp Leu Ala Ile Xaa Glu Lys Asp 
                725                 730                 735     


Pro Pro Gly Val Gly Val Ala Gly Val Ala Ala Ala Pro Lys Gly Lys 
            740                 745                 750         


Glu Lys Asn Gly Gly Ala Arg Leu Gly Met Ala Gly Val Pro Glu Asp 
        755                 760                 765             


Gly Glu Gln Pro Gly Trp Pro Ser Pro Ala Lys Ala Ala Pro Val Leu 
    770                 775                 780                 


Pro Xaa Xaa His Asn His Lys Val Pro Val Leu Ile Ser Pro Xaa Leu 
785                 790                 795                 800 


Lys His Xaa Pro Ala Asp Val Gln Leu Ile Gly Xaa Asp Ser Gln Gly 
                805                 810                 815     


Asn Lys Phe Lys Leu Leu Ser Glu His Gln Val Xaa Ser Ser Gly Asp 
            820                 825                 830         


Lys Asp Arg Pro Arg Arg Val Lys Pro Lys Cys Ala Pro Pro Pro Pro 
        835                 840                 845             


Pro Val Met Arg Leu Leu Gln His Pro Ser Ile Cys Ser Asp Pro Xaa 
    850                 855                 860                 


Glu Glu Pro Xaa Ala Leu Xaa Ala Gly Gln Ser Xaa Ser Glu Xaa Gln 
865                 870                 875                 880 


Glu Gly Gly Lys Lys Ala Ala Leu Gly Ala Val Pro Ile Ser Gly Lys 
                885                 890                 895     


Ala Gly Arg Pro Val Met Pro Pro Pro Gln Val Pro Leu Pro Xaa Ser 
            900                 905                 910         


Ser Ile Ser Pro Ala Lys Met Ala Asn Gly Xaa Ala Gly Xaa Lys Val 
        915                 920                 925             


Ala Leu Arg Lys Xaa Lys Gln Ala Ala Glu Lys Ile Ser Ala Asp Lys 
    930                 935                 940                 


Ile Ser Lys Glu Ala Leu Leu Glu Cys Ala Asp Leu Leu Ser Ser Ala 
945                 950                 955                 960 


Leu Xaa Glu Pro Val Pro Asn Ser Gln Leu Val Asp Xaa Gly His Gln 
                965                 970                 975     


Leu Leu Asp Tyr Cys Ser Gly Tyr Val Asp Cys Ile Pro Gln Xaa Arg 
            980                 985                 990         


Asn Lys Phe Ala Phe Arg Glu Ala  Val Ser Lys Leu Glu  Leu Ser Leu 
        995                 1000                 1005             


Gln Glu  Leu Gln Val Ser Ser  Ala Ala Ala Gly Val  Pro Gly Xaa 
    1010                 1015                 1020             


Asn Pro  Val Leu Asn Asn Leu  Leu Ser Cys Val Gln  Glu Ile Ser 
    1025                 1030                 1035             


Asp Val  Val Gln Arg 
    1040             


<210> 1320
<211> 20
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<400> 1320
Glu Xaa Lys Asn Trp His Xaa Asp Val Ile Glu Met Asn Gly Val Ser 
1               5                   10                  15      


Arg Gly Trp Glu 
            20  


<210> 1321
<211> 49
<212> PRT
<213> Homo sapiens

<400> 1321
Gly Lys Ser Tyr Leu Phe Leu Leu Ser Ser Asp Tyr Glu Arg Ser Glu 
1               5                   10                  15      


Trp Arg Glu Ala Ile Gln Lys Leu Gln Lys Lys Gly Lys Phe Leu Pro 
            20                  25                  30          


Leu Pro Arg Ser Pro Met Met Ser Val Ala Leu Met Gly Leu Leu Phe 
        35                  40                  45              


Phe 
    


<210> 1322
<211> 49
<212> PRT
<213> Homo sapiens

<400> 1322
Gly Lys Ser Tyr Leu Phe Leu Leu Ser Ser Asp Tyr Glu Arg Ser Glu 
1               5                   10                  15      


Trp Arg Glu Ala Ile Gln Lys Leu Gln Lys Lys Gly Lys Phe Leu Pro 
            20                  25                  30          


Leu Pro Arg Ser Pro Met Met Ser Val Ala Leu Met Gly Leu Leu Tyr 
        35                  40                  45              


Phe 
    


<210> 1323
<211> 871
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<400> 1323
Met Ala Ala Gly Gly Arg Arg Arg Arg Pro Leu Arg Tyr Gln Ser Leu 
1               5                   10                  15      


Ala Ala Leu Val Glu Asp Ser Gln Trp Pro Phe Leu Phe Leu Val Ser 
            20                  25                  30          


Asp Phe Ser Tyr Gly Xaa Asp Glu Tyr Asp Gly Glu Gly Asn Glu Glu 
        35                  40                  45              


Gln Lys Gly Pro Pro Glu Gly Ser Glu Xaa Met Pro Tyr Ile Asp Glu 
    50                  55                  60                  


Ser Pro Xaa Met Ser Pro Gln Leu Ser Ala Arg Ser Gln Gly Gly Gly 
65                  70                  75                  80  


Asp Gly Val Ser Pro Xaa Pro Pro Glu Gly Leu Ala Pro Gly Val Glu 
                85                  90                  95      


Ala Gly Lys Gly Leu Glu Met Arg Lys Leu Val Leu Ser Gly Phe Leu 
            100                 105                 110         


Ala Ser Glu Glu Ile Tyr Ile Asn Gln Leu Glu Ala Leu Leu Leu Pro 
        115                 120                 125             


Met Lys Pro Leu Lys Ala Xaa Ala Xaa Xaa Ser Gln Pro Val Leu Xaa 
    130                 135                 140                 


Ile Gln Gln Ile Glu Xaa Ile Phe Tyr Lys Ile Gln Asp Ile Tyr Glu 
145                 150                 155                 160 


Ile His Lys Glu Phe Tyr Asp Asn Leu Cys Pro Lys Val Gln Gln Trp 
                165                 170                 175     


Asp Ser Gln Val Xaa Met Gly His Leu Phe Gln Lys Leu Ala Ser Gln 
            180                 185                 190         


Leu Gly Val Tyr Lys Ala Phe Val Asp Asn Tyr Lys Val Ala Leu Glu 
        195                 200                 205             


Xaa Ala Glu Lys Cys Ser Gln Ser Asn Asn Gln Phe Gln Lys Ile Ser 
    210                 215                 220                 


Glu Glu Leu Lys Val Lys Gly Pro Lys Asp Ser Lys Asp Ser His Xaa 
225                 230                 235                 240 


Ser Val Xaa Met Glu Ala Leu Leu Tyr Lys Pro Ile Asp Arg Val Xaa 
                245                 250                 255     


Arg Ser Xaa Leu Val Leu His Asp Leu Leu Lys His Xaa Pro Val Asp 
            260                 265                 270         


His Pro Asp Tyr Pro Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn 
        275                 280                 285             


Phe Leu Ser Ser Ile Asn Glu Asp Ile Asp Pro Arg Arg Xaa Ala Val 
    290                 295                 300                 


Xaa Xaa Pro Lys Gly Glu Xaa Arg Gln Leu Val Lys Asp Gly Phe Leu 
305                 310                 315                 320 


Val Glu Val Ser Glu Ser Ser Arg Lys Leu Arg His Val Phe Leu Phe 
                325                 330                 335     


Xaa Asp Val Leu Leu Cys Ala Lys Leu Lys Lys Xaa Ser Ala Gly Lys 
            340                 345                 350         


His Gln Gln Tyr Asp Cys Lys Trp Tyr Ile Pro Leu Ala Asp Leu Val 
        355                 360                 365             


Phe Pro Ser Pro Glu Glu Ser Glu Ala Ser Pro Gln Val His Pro Phe 
    370                 375                 380                 


Pro Asp His Glu Leu Glu Asp Met Lys Met Lys Ile Ser Ala Leu Lys 
385                 390                 395                 400 


Ser Glu Ile Gln Lys Glu Lys Ala Asn Lys Gly Gln Ser Arg Ala Ile 
                405                 410                 415     


Glu Arg Leu Lys Lys Lys Met Phe Glu Asn Glu Phe Leu Leu Leu Leu 
            420                 425                 430         


Asn Ser Pro Xaa Ile Pro Phe Arg Ile His Asn Arg Asn Gly Lys Ser 
        435                 440                 445             


Tyr Leu Phe Leu Leu Ser Ser Asp Tyr Glu Arg Ser Glu Trp Arg Glu 
    450                 455                 460                 


Ala Ile Gln Lys Leu Gln Lys Lys Asp Leu Gln Ala Phe Val Leu Ser 
465                 470                 475                 480 


Ser Val Glu Leu Gln Val Leu Xaa Gly Ser Cys Phe Lys Leu Arg Xaa 
                485                 490                 495     


Val His Asn Ile Pro Val Xaa Ser Asn Lys Asp Asp Asp Glu Ser Pro 
            500                 505                 510         


Gly Leu Tyr Gly Phe Leu His Val Ile Val His Ser Ala Lys Gly Phe 
        515                 520                 525             


Lys Gln Ser Ala Asn Leu Tyr Cys Xaa Leu Glu Val Asp Ser Phe Gly 
    530                 535                 540                 


Tyr Phe Val Ser Lys Ala Lys Xaa Arg Val Phe Arg Asp Xaa Ala Glu 
545                 550                 555                 560 


Pro Lys Trp Asp Glu Glu Phe Glu Ile Glu Leu Glu Gly Ser Gln Ser 
                565                 570                 575     


Leu Arg Ile Leu Cys Tyr Glu Lys Cys Tyr Asp Lys Xaa Lys Val Asn 
            580                 585                 590         


Lys Asp Asn Asn Glu Ile Val Asp Lys Ile Met Gly Lys Gly Gln Ile 
        595                 600                 605             


Gln Leu Asp Pro Gln Xaa Val Glu Xaa Lys Asn Trp His Xaa Asp Val 
    610                 615                 620                 


Ile Glu Met Asn Gly Ile Lys Val Glu Phe Ser Met Lys Phe Xaa Ser 
625                 630                 635                 640 


Arg Asp Met Ser Leu Lys Arg Xaa Pro Ser Lys Lys Gln Xaa Gly Val 
                645                 650                 655     


Phe Gly Val Lys Ile Ser Val Val Xaa Lys Arg Glu Arg Ser Lys Val 
            660                 665                 670         


Pro Tyr Ile Val Arg Gln Cys Val Glu Glu Val Glu Lys Arg Gly Ile 
        675                 680                 685             


Glu Glu Val Gly Ile Tyr Arg Ile Ser Gly Val Ala Xaa Asp Ile Gln 
    690                 695                 700                 


Ala Leu Lys Ala Val Phe Asp Ala Asn Asn Lys Asp Ile Leu Leu Met 
705                 710                 715                 720 


Leu Ser Asp Met Asp Ile Asn Ala Ile Ala Gly Xaa Leu Lys Leu Tyr 
                725                 730                 735     


Phe Arg Glu Leu Pro Glu Pro Leu Leu Xaa Asp Arg Leu Tyr Pro Ala 
            740                 745                 750         


Phe Met Glu Gly Ile Ala Leu Ser Asp Pro Ala Ala Lys Glu Asn Cys 
        755                 760                 765             


Met Met His Leu Leu Arg Ser Leu Pro Asp Pro Asn Leu Ile Xaa Phe 
    770                 775                 780                 


Leu Phe Leu Leu Glu His Leu Lys Arg Val Ala Glu Lys Glu Pro Ile 
785                 790                 795                 800 


Asn Lys Met Ser Leu His Asn Leu Ala Xaa Val Phe Gly Pro Xaa Leu 
                805                 810                 815     


Leu Arg Pro Ser Glu Val Glu Ser Lys Ala His Leu Xaa Ser Ala Ala 
            820                 825                 830         


Asp Ile Trp Ser His Asp Val Met Ala Gln Val Gln Val Leu Leu Tyr 
        835                 840                 845             


Tyr Leu Gln His Pro Pro Ile Ser Phe Ala Glu Leu Lys Arg Asn Xaa 
    850                 855                 860                 


Leu Tyr Phe Ser Xaa Asp Val 
865                 870     


<210> 1324
<211> 822
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<400> 1324
Met Glu Glu Glu Glu Glu Ala Ile Gly Leu Leu Asp Lys Val Leu Glu 
1               5                   10                  15      


Asp Glu Asp Val Phe Leu Leu Glu Glu Cys Glu Leu Gly Xaa Pro Xaa 
            20                  25                  30          


Ser Pro Gly Ser Gly Ser Pro Phe Leu Val Ala Val Lys Val Glu Ala 
        35                  40                  45              


Gly Lys Gly Leu Glu Met Arg Lys Leu Val Leu Ser Gly Phe Leu Ala 
    50                  55                  60                  


Ser Glu Glu Ile Tyr Ile Asn Gln Leu Glu Ala Leu Leu Leu Pro Met 
65                  70                  75                  80  


Lys Pro Leu Lys Ala Xaa Ala Xaa Xaa Ser Gln Pro Val Leu Xaa Ile 
                85                  90                  95      


Gln Gln Ile Glu Xaa Ile Phe Tyr Lys Ile Gln Asp Ile Tyr Glu Ile 
            100                 105                 110         


His Lys Glu Phe Tyr Asp Asn Leu Cys Pro Lys Val Gln Gln Trp Asp 
        115                 120                 125             


Ser Gln Val Xaa Met Gly His Leu Phe Gln Lys Leu Ala Ser Gln Leu 
    130                 135                 140                 


Gly Val Tyr Lys Ala Phe Val Asp Asn Tyr Lys Val Ala Leu Glu Xaa 
145                 150                 155                 160 


Ala Glu Lys Cys Ser Gln Ser Asn Asn Gln Phe Gln Lys Ile Ser Glu 
                165                 170                 175     


Glu Leu Lys Val Lys Gly Pro Lys Asp Ser Lys Asp Ser His Xaa Ser 
            180                 185                 190         


Val Xaa Met Glu Ala Leu Leu Tyr Lys Pro Ile Asp Arg Val Xaa Arg 
        195                 200                 205             


Ser Xaa Leu Val Leu His Asp Leu Leu Lys His Xaa Pro Val Asp His 
    210                 215                 220                 


Pro Asp Tyr Pro Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe 
225                 230                 235                 240 


Leu Ser Ser Ile Asn Glu Asp Ile Asp Pro Arg Arg Xaa Ala Val Xaa 
                245                 250                 255     


Xaa Pro Lys Gly Glu Xaa Arg Gln Leu Val Lys Asp Gly Phe Leu Val 
            260                 265                 270         


Glu Val Ser Glu Ser Ser Arg Lys Leu Arg His Val Phe Leu Phe Xaa 
        275                 280                 285             


Asp Val Leu Leu Cys Ala Lys Leu Lys Lys Xaa Ser Ala Gly Lys His 
    290                 295                 300                 


Gln Gln Tyr Asp Cys Lys Trp Tyr Ile Pro Leu Ala Asp Leu Val Phe 
305                 310                 315                 320 


Pro Ser Pro Glu Glu Ser Glu Ala Ser Pro Gln Val His Pro Phe Pro 
                325                 330                 335     


Asp His Glu Leu Glu Asp Met Lys Met Lys Ile Ser Ala Leu Lys Ser 
            340                 345                 350         


Glu Ile Gln Lys Glu Lys Ala Asn Lys Gly Gln Ser Arg Ala Ile Glu 
        355                 360                 365             


Arg Leu Lys Lys Lys Met Phe Glu Asn Glu Phe Leu Leu Leu Leu Asn 
    370                 375                 380                 


Ser Pro Xaa Ile Pro Phe Arg Ile His Asn Arg Asn Gly Lys Ser Tyr 
385                 390                 395                 400 


Leu Phe Leu Leu Ser Ser Asp Tyr Glu Arg Ser Glu Trp Arg Glu Ala 
                405                 410                 415     


Ile Gln Lys Leu Gln Lys Lys Asp Leu Gln Ala Phe Val Leu Ser Ser 
            420                 425                 430         


Val Glu Leu Gln Val Leu Xaa Gly Ser Cys Phe Lys Leu Arg Xaa Val 
        435                 440                 445             


His Asn Ile Pro Val Xaa Ser Asn Lys Asp Asp Asp Glu Ser Pro Gly 
    450                 455                 460                 


Leu Tyr Gly Phe Leu His Val Ile Val His Ser Ala Lys Gly Phe Lys 
465                 470                 475                 480 


Gln Ser Ala Asn Leu Tyr Cys Xaa Leu Glu Val Asp Ser Phe Gly Tyr 
                485                 490                 495     


Phe Val Ser Lys Ala Lys Xaa Arg Val Phe Arg Asp Xaa Ala Glu Pro 
            500                 505                 510         


Lys Trp Asp Glu Glu Phe Glu Ile Glu Leu Glu Gly Ser Gln Ser Leu 
        515                 520                 525             


Arg Ile Leu Cys Tyr Glu Lys Cys Tyr Asp Lys Xaa Lys Val Asn Lys 
    530                 535                 540                 


Asp Asn Asn Glu Ile Val Asp Lys Ile Met Gly Lys Gly Gln Ile Gln 
545                 550                 555                 560 


Leu Asp Pro Gln Xaa Val Glu Xaa Lys Asn Trp His Xaa Asp Val Ile 
                565                 570                 575     


Glu Met Asn Gly Ile Lys Val Glu Phe Ser Met Lys Phe Xaa Ser Arg 
            580                 585                 590         


Asp Met Ser Leu Lys Arg Xaa Pro Ser Lys Lys Gln Xaa Gly Val Phe 
        595                 600                 605             


Gly Val Lys Ile Ser Val Val Xaa Lys Arg Glu Arg Ser Lys Val Pro 
    610                 615                 620                 


Tyr Ile Val Arg Gln Cys Val Glu Glu Val Glu Lys Arg Gly Ile Glu 
625                 630                 635                 640 


Glu Val Gly Ile Tyr Arg Ile Ser Gly Val Ala Xaa Asp Ile Gln Ala 
                645                 650                 655     


Leu Lys Ala Val Phe Asp Ala Asn Asn Lys Asp Ile Leu Leu Met Leu 
            660                 665                 670         


Ser Asp Met Asp Ile Asn Ala Ile Ala Gly Xaa Leu Lys Leu Tyr Phe 
        675                 680                 685             


Arg Glu Leu Pro Glu Pro Leu Leu Xaa Asp Arg Leu Tyr Pro Ala Phe 
    690                 695                 700                 


Met Glu Gly Ile Ala Leu Ser Asp Pro Ala Ala Lys Glu Asn Cys Met 
705                 710                 715                 720 


Met His Leu Leu Arg Ser Leu Pro Asp Pro Asn Leu Ile Xaa Phe Leu 
                725                 730                 735     


Phe Leu Leu Glu His Leu Lys Arg Val Ala Glu Lys Glu Pro Ile Asn 
            740                 745                 750         


Lys Met Ser Leu His Asn Leu Ala Xaa Val Phe Gly Pro Xaa Leu Leu 
        755                 760                 765             


Arg Pro Ser Glu Val Glu Ser Lys Ala His Leu Xaa Ser Ala Ala Asp 
    770                 775                 780                 


Ile Trp Ser His Asp Val Met Ala Gln Val Gln Val Leu Leu Tyr Tyr 
785                 790                 795                 800 


Leu Gln His Pro Pro Ile Ser Phe Ala Glu Leu Lys Arg Asn Xaa Leu 
                805                 810                 815     


Tyr Phe Ser Xaa Asp Val 
            820         


<210> 1325
<211> 641
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<400> 1325
Met Glu Ile Leu Leu Ile Ile Arg Phe Cys Cys Asn Cys Xaa Tyr Ala 
1               5                   10                  15      


Leu Leu Tyr Lys Pro Ile Asp Arg Val Xaa Arg Ser Xaa Leu Val Leu 
            20                  25                  30          


His Asp Leu Leu Lys His Xaa Pro Val Asp His Pro Asp Tyr Pro Leu 
        35                  40                  45              


Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile Asn 
    50                  55                  60                  


Glu Asp Ile Asp Pro Arg Arg Xaa Ala Val Xaa Xaa Pro Lys Gly Glu 
65                  70                  75                  80  


Xaa Arg Gln Leu Val Lys Asp Gly Phe Leu Val Glu Val Ser Glu Ser 
                85                  90                  95      


Ser Arg Lys Leu Arg His Val Phe Leu Phe Xaa Asp Val Leu Leu Cys 
            100                 105                 110         


Ala Lys Leu Lys Lys Xaa Ser Ala Gly Lys His Gln Gln Tyr Asp Cys 
        115                 120                 125             


Lys Trp Tyr Ile Pro Leu Ala Asp Leu Val Phe Pro Ser Pro Glu Glu 
    130                 135                 140                 


Ser Glu Ala Ser Pro Gln Val His Pro Phe Pro Asp His Glu Leu Glu 
145                 150                 155                 160 


Asp Met Lys Met Lys Ile Ser Ala Leu Lys Ser Glu Ile Gln Lys Glu 
                165                 170                 175     


Lys Ala Asn Lys Gly Gln Ser Arg Ala Ile Glu Arg Leu Lys Lys Lys 
            180                 185                 190         


Met Phe Glu Asn Glu Phe Leu Leu Leu Leu Asn Ser Pro Xaa Ile Pro 
        195                 200                 205             


Phe Arg Ile His Asn Arg Asn Gly Lys Ser Tyr Leu Phe Leu Leu Ser 
    210                 215                 220                 


Ser Asp Tyr Glu Arg Ser Glu Trp Arg Glu Ala Ile Gln Lys Leu Gln 
225                 230                 235                 240 


Lys Lys Asp Leu Gln Ala Phe Val Leu Ser Ser Val Glu Leu Gln Val 
                245                 250                 255     


Leu Xaa Gly Ser Cys Phe Lys Leu Arg Xaa Val His Asn Ile Pro Val 
            260                 265                 270         


Xaa Ser Asn Lys Asp Asp Asp Glu Ser Pro Gly Leu Tyr Gly Phe Leu 
        275                 280                 285             


His Val Ile Val His Ser Ala Lys Gly Phe Lys Gln Ser Ala Asn Leu 
    290                 295                 300                 


Tyr Cys Xaa Leu Glu Val Asp Ser Phe Gly Tyr Phe Val Ser Lys Ala 
305                 310                 315                 320 


Lys Xaa Arg Val Phe Arg Asp Xaa Ala Glu Pro Lys Trp Asp Glu Glu 
                325                 330                 335     


Phe Glu Ile Glu Leu Glu Gly Ser Gln Ser Leu Arg Ile Leu Cys Tyr 
            340                 345                 350         


Glu Lys Cys Tyr Asp Lys Xaa Lys Val Asn Lys Asp Asn Asn Glu Ile 
        355                 360                 365             


Val Asp Lys Ile Met Gly Lys Gly Gln Ile Gln Leu Asp Pro Gln Xaa 
    370                 375                 380                 


Val Glu Xaa Lys Asn Trp His Xaa Asp Val Ile Glu Met Asn Gly Ile 
385                 390                 395                 400 


Lys Val Glu Phe Ser Met Lys Phe Xaa Ser Arg Asp Met Ser Leu Lys 
                405                 410                 415     


Arg Xaa Pro Ser Lys Lys Gln Xaa Gly Val Phe Gly Val Lys Ile Ser 
            420                 425                 430         


Val Val Xaa Lys Arg Glu Arg Ser Lys Val Pro Tyr Ile Val Arg Gln 
        435                 440                 445             


Cys Val Glu Glu Val Glu Lys Arg Gly Ile Glu Glu Val Gly Ile Tyr 
    450                 455                 460                 


Arg Ile Ser Gly Val Ala Xaa Asp Ile Gln Ala Leu Lys Ala Val Phe 
465                 470                 475                 480 


Asp Ala Asn Asn Lys Asp Ile Leu Leu Met Leu Ser Asp Met Asp Ile 
                485                 490                 495     


Asn Ala Ile Ala Gly Xaa Leu Lys Leu Tyr Phe Arg Glu Leu Pro Glu 
            500                 505                 510         


Pro Leu Leu Xaa Asp Arg Leu Tyr Pro Ala Phe Met Glu Gly Ile Ala 
        515                 520                 525             


Leu Ser Asp Pro Ala Ala Lys Glu Asn Cys Met Met His Leu Leu Arg 
    530                 535                 540                 


Ser Leu Pro Asp Pro Asn Leu Ile Xaa Phe Leu Phe Leu Leu Glu His 
545                 550                 555                 560 


Leu Lys Arg Val Ala Glu Lys Glu Pro Ile Asn Lys Met Ser Leu His 
                565                 570                 575     


Asn Leu Ala Xaa Val Phe Gly Pro Xaa Leu Leu Arg Pro Ser Glu Val 
            580                 585                 590         


Glu Ser Lys Ala His Leu Xaa Ser Ala Ala Asp Ile Trp Ser His Asp 
        595                 600                 605             


Val Met Ala Gln Val Gln Val Leu Leu Tyr Tyr Leu Gln His Pro Pro 
    610                 615                 620                 


Ile Ser Phe Ala Glu Leu Lys Arg Asn Xaa Leu Tyr Phe Ser Xaa Asp 
625                 630                 635                 640 


Val 
    


<210> 1326
<211> 165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<400> 1326
Met Glu Ile Leu Leu Ile Ile Arg Phe Cys Cys Asn Cys Xaa Tyr Gly 
1               5                   10                  15      


Asn Pro Ala Leu Leu Tyr Lys Pro Ile Asp Arg Val Xaa Arg Ser Xaa 
            20                  25                  30          


Leu Val Leu His Asp Leu Leu Lys His Xaa Pro Val Asp His Pro Asp 
        35                  40                  45              


Tyr Pro Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser 
    50                  55                  60                  


Ser Ile Asn Glu Asp Ile Asp Pro Arg Arg Xaa Ala Val Xaa Xaa Pro 
65                  70                  75                  80  


Lys Gly Glu Xaa Arg Gln Leu Val Lys Asp Gly Phe Leu Val Glu Val 
                85                  90                  95      


Ser Glu Ser Ser Arg Lys Leu Arg His Val Phe Leu Phe Xaa Asp Val 
            100                 105                 110         


Leu Leu Cys Ala Lys Leu Lys Lys Xaa Ser Ala Gly Lys His Gln Gln 
        115                 120                 125             


Tyr Asp Cys Lys Trp Tyr Ile Pro Leu Ala Asp Leu Val Phe Pro Ser 
    130                 135                 140                 


Pro Glu Glu Ser Glu Ala Ser Pro Gln Val His Pro Phe Pro Asp His 
145                 150                 155                 160 


Glu Leu Glu Asp Met 
                165 


<210> 1327
<211> 859
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<400> 1327
Met Glu Pro Leu Ser His Arg Gly Leu Pro Arg Leu Ser Trp Ile Asp 
1               5                   10                  15      


Xaa Leu Tyr Ser Asn Phe Ser Tyr Gly Xaa Asp Glu Tyr Asp Gly Glu 
            20                  25                  30          


Gly Asn Glu Glu Gln Lys Gly Pro Pro Glu Gly Ser Glu Xaa Met Pro 
        35                  40                  45              


Tyr Ile Asp Glu Ser Pro Xaa Met Ser Pro Gln Leu Ser Ala Arg Ser 
    50                  55                  60                  


Gln Gly Gly Gly Asp Gly Val Ser Pro Xaa Pro Pro Glu Gly Leu Ala 
65                  70                  75                  80  


Pro Gly Val Glu Ala Gly Lys Gly Leu Glu Met Arg Lys Leu Val Leu 
                85                  90                  95      


Ser Gly Phe Leu Ala Ser Glu Glu Ile Tyr Ile Asn Gln Leu Glu Ala 
            100                 105                 110         


Leu Leu Leu Pro Met Lys Pro Leu Lys Ala Xaa Ala Xaa Xaa Ser Gln 
        115                 120                 125             


Pro Val Leu Xaa Ile Gln Gln Ile Glu Xaa Ile Phe Tyr Lys Ile Gln 
    130                 135                 140                 


Asp Ile Tyr Glu Ile His Lys Glu Phe Tyr Asp Asn Leu Cys Pro Lys 
145                 150                 155                 160 


Val Gln Gln Trp Asp Ser Gln Val Xaa Met Gly His Leu Phe Gln Lys 
                165                 170                 175     


Leu Ala Ser Gln Leu Gly Val Tyr Lys Ala Phe Val Asp Asn Tyr Lys 
            180                 185                 190         


Val Ala Leu Glu Xaa Ala Glu Lys Cys Ser Gln Ser Asn Asn Gln Phe 
        195                 200                 205             


Gln Lys Ile Ser Glu Glu Leu Lys Val Lys Gly Pro Lys Asp Ser Lys 
    210                 215                 220                 


Asp Ser His Xaa Ser Val Xaa Met Glu Ala Leu Leu Tyr Lys Pro Ile 
225                 230                 235                 240 


Asp Arg Val Xaa Arg Ser Xaa Leu Val Leu His Asp Leu Leu Lys His 
                245                 250                 255     


Xaa Pro Val Asp His Pro Asp Tyr Pro Leu Leu Gln Asp Ala Leu Arg 
            260                 265                 270         


Ile Ser Gln Asn Phe Leu Ser Ser Ile Asn Glu Asp Ile Asp Pro Arg 
        275                 280                 285             


Arg Xaa Ala Val Xaa Xaa Pro Lys Gly Glu Xaa Arg Gln Leu Val Lys 
    290                 295                 300                 


Asp Gly Phe Leu Val Glu Val Ser Glu Ser Ser Arg Lys Leu Arg His 
305                 310                 315                 320 


Val Phe Leu Phe Xaa Asp Val Leu Leu Cys Ala Lys Leu Lys Lys Xaa 
                325                 330                 335     


Ser Ala Gly Lys His Gln Gln Tyr Asp Cys Lys Trp Tyr Ile Pro Leu 
            340                 345                 350         


Ala Asp Leu Val Phe Pro Ser Pro Glu Glu Ser Glu Ala Ser Pro Gln 
        355                 360                 365             


Val His Pro Phe Pro Asp His Glu Leu Glu Asp Met Lys Met Lys Ile 
    370                 375                 380                 


Ser Ala Leu Lys Ser Glu Ile Gln Lys Glu Lys Ala Asn Lys Gly Gln 
385                 390                 395                 400 


Ser Arg Ala Ile Glu Arg Leu Lys Lys Lys Met Phe Glu Asn Glu Phe 
                405                 410                 415     


Leu Leu Leu Leu Asn Ser Pro Xaa Ile Pro Phe Arg Ile His Asn Arg 
            420                 425                 430         


Asn Gly Lys Ser Tyr Leu Phe Leu Leu Ser Ser Asp Tyr Glu Arg Ser 
        435                 440                 445             


Glu Trp Arg Glu Ala Ile Gln Lys Leu Gln Lys Lys Asp Leu Gln Ala 
    450                 455                 460                 


Phe Val Leu Ser Ser Val Glu Leu Gln Val Leu Xaa Gly Ser Cys Phe 
465                 470                 475                 480 


Lys Leu Arg Xaa Val His Asn Ile Pro Val Xaa Ser Asn Lys Asp Asp 
                485                 490                 495     


Asp Glu Ser Pro Gly Leu Tyr Gly Phe Leu His Val Ile Val His Ser 
            500                 505                 510         


Ala Lys Gly Phe Lys Gln Ser Ala Asn Leu Tyr Cys Xaa Leu Glu Val 
        515                 520                 525             


Asp Ser Phe Gly Tyr Phe Val Ser Lys Ala Lys Xaa Arg Val Phe Arg 
    530                 535                 540                 


Asp Xaa Ala Glu Pro Lys Trp Asp Glu Glu Phe Glu Ile Glu Leu Glu 
545                 550                 555                 560 


Gly Ser Gln Ser Leu Arg Ile Leu Cys Tyr Glu Lys Cys Tyr Asp Lys 
                565                 570                 575     


Xaa Lys Val Asn Lys Asp Asn Asn Glu Ile Val Asp Lys Ile Met Gly 
            580                 585                 590         


Lys Gly Gln Ile Gln Leu Asp Pro Gln Xaa Val Glu Xaa Lys Asn Trp 
        595                 600                 605             


His Xaa Asp Val Ile Glu Met Asn Gly Ile Lys Val Glu Phe Ser Met 
    610                 615                 620                 


Lys Phe Xaa Ser Arg Asp Met Ser Leu Lys Arg Xaa Pro Ser Lys Lys 
625                 630                 635                 640 


Gln Xaa Gly Val Phe Gly Val Lys Ile Ser Val Val Xaa Lys Arg Glu 
                645                 650                 655     


Arg Ser Lys Val Pro Tyr Ile Val Arg Gln Cys Val Glu Glu Val Glu 
            660                 665                 670         


Lys Arg Gly Ile Glu Glu Val Gly Ile Tyr Arg Ile Ser Gly Val Ala 
        675                 680                 685             


Xaa Asp Ile Gln Ala Leu Lys Ala Val Phe Asp Ala Asn Asn Lys Asp 
    690                 695                 700                 


Ile Leu Leu Met Leu Ser Asp Met Asp Ile Asn Ala Ile Ala Gly Xaa 
705                 710                 715                 720 


Leu Lys Leu Tyr Phe Arg Glu Leu Pro Glu Pro Leu Leu Xaa Asp Arg 
                725                 730                 735     


Leu Tyr Pro Ala Phe Met Glu Gly Ile Ala Leu Ser Asp Pro Ala Ala 
            740                 745                 750         


Lys Glu Asn Cys Met Met His Leu Leu Arg Ser Leu Pro Asp Pro Asn 
        755                 760                 765             


Leu Ile Xaa Phe Leu Phe Leu Leu Glu His Leu Lys Arg Val Ala Glu 
    770                 775                 780                 


Lys Glu Pro Ile Asn Lys Met Ser Leu His Asn Leu Ala Xaa Val Phe 
785                 790                 795                 800 


Gly Pro Xaa Leu Leu Arg Pro Ser Glu Val Glu Ser Lys Ala His Leu 
                805                 810                 815     


Xaa Ser Ala Ala Asp Ile Trp Ser His Asp Val Met Ala Gln Val Gln 
            820                 825                 830         


Val Leu Leu Tyr Tyr Leu Gln His Pro Pro Ile Ser Phe Ala Glu Leu 
        835                 840                 845             


Lys Arg Asn Xaa Leu Tyr Phe Ser Xaa Asp Val 
    850                 855                 


<210> 1328
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<400> 1328
Met Pro Tyr Ile Asp Glu Ser Pro Xaa Met Ser Pro Gln Leu Ser Ala 
1               5                   10                  15      


Arg Ser Gln Gly Gly Gly Asp Gly Val Ser Pro Xaa Pro Pro Glu Gly 
            20                  25                  30          


Leu Ala Pro Gly Pro Met Lys Pro Leu Lys Ala Xaa Ala Xaa Xaa Ser 
        35                  40                  45              


Gln Pro Val Leu Xaa Ile Gln Gln Ile Glu Xaa Ile Phe Tyr Lys Ile 
    50                  55                  60                  


Gln Asp Ile Tyr Glu Ile His Lys Glu Phe Tyr Asp Asn Leu Cys Pro 
65                  70                  75                  80  


Lys Val Gln Gln Trp Asp Ser Gln Val Xaa Met Gly His Leu Phe Gln 
                85                  90                  95      


Lys Leu Ala Ser Gln Leu Gly Val Tyr Lys Ala Phe Val Asp Asn Tyr 
            100                 105                 110         


Lys Val Ala Leu Glu Xaa Ala Glu Lys Cys Ser Gln Ser Asn Asn Gln 
        115                 120                 125             


Phe Gln Lys Ile Ser 
    130             


<210> 1329
<211> 86
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 1329
Met Pro Tyr Ile Asp Glu Ser Pro Xaa Met Ser Pro Gln Leu Ser Ala 
1               5                   10                  15      


Arg Ser Gln Gly Gly Gly Asp Gly Val Ser Pro Xaa Pro Pro Glu Gly 
            20                  25                  30          


Leu Ala Pro Gly Val Glu Ala Gly Lys Gly Leu Glu Met Arg Lys Leu 
        35                  40                  45              


Val Leu Ser Gly Phe Leu Ala Ser Glu Glu Ile Tyr Ile Asn Gln Leu 
    50                  55                  60                  


Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys Ala Xaa Ala Xaa Xaa 
65                  70                  75                  80  


Ser Gln Pro Val Leu Xaa 
                85      


<210> 1330
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 1330
Met Pro Tyr Ile Asp Glu Ser Pro Xaa Met Ser Pro Gln Leu Ser Ala 
1               5                   10                  15      


Arg Ser Gln Gly Gly Gly Asp Gly Val Ser Pro Xaa Pro Pro Glu Gly 
            20                  25                  30          


Leu Ala Pro Gly Val Glu Ala Gly Lys Gly Leu Glu Met Arg Lys Leu 
        35                  40                  45              


Val Leu Ser Gly Phe Leu Ala Ser Glu Glu Ile Tyr Ile Asn Gln Leu 
    50                  55                  60                  


Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys Ala Xaa Ala Xaa Xaa 
65                  70                  75                  80  


Ser Gln Pro Val Leu Xaa Ile Gln 
                85              


<210> 1331
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<400> 1331
Met Pro Tyr Ile Asp Glu Ser Pro Xaa Met Ser Pro Gln Leu Ser Ala 
1               5                   10                  15      


Arg Ser Gln Gly Gly Gly Asp Gly Val Ser Pro Xaa Pro Pro Glu Gly 
            20                  25                  30          


Leu Ala Pro Gly Val Glu Ala Gly Lys Gly Leu Glu Met Arg Lys Leu 
        35                  40                  45              


Val Leu Ser Gly Phe Leu Ala Ser Glu Glu Ile Tyr Ile Asn Gln Leu 
    50                  55                  60                  


Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys Ala Xaa Ala Xaa Xaa 
65                  70                  75                  80  


Ser Gln Pro Val Leu Xaa Ile Gln Gln Ile Glu Xaa Ile Phe Tyr Lys 
                85                  90                  95      


Ile Gln Asp Ile Tyr Glu Ile His Lys Glu Phe Tyr Asp Asn Leu Cys 
            100                 105                 110         


Pro Lys Val Gln Gln Trp Asp Ser Gln Val Xaa Met Gly His Leu Phe 
        115                 120                 125             


Gln 
    


<210> 1332
<211> 813
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<400> 1332
Met Pro Tyr Ile Asp Glu Ser Pro Xaa Met Ser Pro Gln Leu Ser Ala 
1               5                   10                  15      


Arg Ser Gln Gly Gly Gly Asp Gly Val Ser Pro Xaa Pro Pro Glu Gly 
            20                  25                  30          


Leu Ala Pro Gly Val Glu Ala Gly Lys Gly Leu Glu Met Arg Lys Leu 
        35                  40                  45              


Val Leu Ser Gly Phe Leu Ala Ser Glu Glu Ile Tyr Ile Asn Gln Leu 
    50                  55                  60                  


Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys Ala Xaa Ala Xaa Xaa 
65                  70                  75                  80  


Ser Gln Pro Val Leu Xaa Ile Gln Gln Ile Glu Xaa Ile Phe Tyr Lys 
                85                  90                  95      


Ile Gln Asp Ile Tyr Glu Ile His Lys Glu Phe Tyr Asp Asn Leu Cys 
            100                 105                 110         


Pro Lys Val Gln Gln Trp Asp Ser Gln Val Xaa Met Gly His Leu Phe 
        115                 120                 125             


Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Lys Ala Phe Val Asp Asn 
    130                 135                 140                 


Tyr Lys Val Ala Leu Glu Xaa Ala Glu Lys Cys Ser Gln Ser Asn Asn 
145                 150                 155                 160 


Gln Phe Gln Lys Ile Ser Glu Glu Leu Lys Val Lys Gly Pro Lys Asp 
                165                 170                 175     


Ser Lys Asp Ser His Xaa Ser Val Xaa Met Glu Ala Leu Leu Tyr Lys 
            180                 185                 190         


Pro Ile Asp Arg Val Xaa Arg Ser Xaa Leu Val Leu His Asp Leu Leu 
        195                 200                 205             


Lys His Xaa Pro Val Asp His Pro Asp Tyr Pro Leu Leu Gln Asp Ala 
    210                 215                 220                 


Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile Asn Glu Asp Ile Asp 
225                 230                 235                 240 


Pro Arg Arg Xaa Ala Val Xaa Xaa Pro Lys Gly Glu Xaa Arg Gln Leu 
                245                 250                 255     


Val Lys Asp Gly Phe Leu Val Glu Val Ser Glu Ser Ser Arg Lys Leu 
            260                 265                 270         


Arg His Val Phe Leu Phe Xaa Asp Val Leu Leu Cys Ala Lys Leu Lys 
        275                 280                 285             


Lys Xaa Ser Ala Gly Lys His Gln Gln Tyr Asp Cys Lys Trp Tyr Ile 
    290                 295                 300                 


Pro Leu Ala Asp Leu Val Phe Pro Ser Pro Glu Glu Ser Glu Ala Ser 
305                 310                 315                 320 


Pro Gln Val His Pro Phe Pro Asp His Glu Leu Glu Asp Met Lys Met 
                325                 330                 335     


Lys Ile Ser Ala Leu Lys Ser Glu Ile Gln Lys Glu Lys Ala Asn Lys 
            340                 345                 350         


Gly Gln Ser Arg Ala Ile Glu Arg Leu Lys Lys Lys Met Phe Glu Asn 
        355                 360                 365             


Glu Phe Leu Leu Leu Leu Asn Ser Pro Xaa Ile Pro Phe Arg Ile His 
    370                 375                 380                 


Asn Arg Asn Gly Lys Ser Tyr Leu Phe Leu Leu Ser Ser Asp Tyr Glu 
385                 390                 395                 400 


Arg Ser Glu Trp Arg Glu Ala Ile Gln Lys Leu Gln Lys Lys Asp Leu 
                405                 410                 415     


Gln Ala Phe Val Leu Ser Ser Val Glu Leu Gln Val Leu Xaa Gly Ser 
            420                 425                 430         


Cys Phe Lys Leu Arg Xaa Val His Asn Ile Pro Val Xaa Ser Asn Lys 
        435                 440                 445             


Asp Asp Asp Glu Ser Pro Gly Leu Tyr Gly Phe Leu His Val Ile Val 
    450                 455                 460                 


His Ser Ala Lys Gly Phe Lys Gln Ser Ala Asn Leu Tyr Cys Xaa Leu 
465                 470                 475                 480 


Glu Val Asp Ser Phe Gly Tyr Phe Val Ser Lys Ala Lys Xaa Arg Val 
                485                 490                 495     


Phe Arg Asp Xaa Ala Glu Pro Lys Trp Asp Glu Glu Phe Glu Ile Glu 
            500                 505                 510         


Leu Glu Gly Ser Gln Ser Leu Arg Ile Leu Cys Tyr Glu Lys Cys Tyr 
        515                 520                 525             


Asp Lys Xaa Lys Val Asn Lys Asp Asn Asn Glu Ile Val Asp Lys Ile 
    530                 535                 540                 


Met Gly Lys Gly Gln Ile Gln Leu Asp Pro Gln Xaa Val Glu Xaa Lys 
545                 550                 555                 560 


Asn Trp His Xaa Asp Val Ile Glu Met Asn Gly Ile Lys Val Glu Phe 
                565                 570                 575     


Ser Met Lys Phe Xaa Ser Arg Asp Met Ser Leu Lys Arg Xaa Pro Ser 
            580                 585                 590         


Lys Lys Gln Xaa Gly Val Phe Gly Val Lys Ile Ser Val Val Xaa Lys 
        595                 600                 605             


Arg Glu Arg Ser Lys Val Pro Tyr Ile Val Arg Gln Cys Val Glu Glu 
    610                 615                 620                 


Val Glu Lys Arg Gly Ile Glu Glu Val Gly Ile Tyr Arg Ile Ser Gly 
625                 630                 635                 640 


Val Ala Xaa Asp Ile Gln Ala Leu Lys Ala Val Phe Asp Ala Asn Asn 
                645                 650                 655     


Lys Asp Ile Leu Leu Met Leu Ser Asp Met Asp Ile Asn Ala Ile Ala 
            660                 665                 670         


Gly Xaa Leu Lys Leu Tyr Phe Arg Glu Leu Pro Glu Pro Leu Leu Xaa 
        675                 680                 685             


Asp Arg Leu Tyr Pro Ala Phe Met Glu Gly Ile Ala Leu Ser Asp Pro 
    690                 695                 700                 


Ala Ala Lys Glu Asn Cys Met Met His Leu Leu Arg Ser Leu Pro Asp 
705                 710                 715                 720 


Pro Asn Leu Ile Xaa Phe Leu Phe Leu Leu Glu His Leu Lys Arg Val 
                725                 730                 735     


Ala Glu Lys Glu Pro Ile Asn Lys Met Ser Leu His Asn Leu Ala Xaa 
            740                 745                 750         


Val Phe Gly Pro Xaa Leu Leu Arg Pro Ser Glu Val Glu Ser Lys Ala 
        755                 760                 765             


His Leu Xaa Ser Ala Ala Asp Ile Trp Ser His Asp Val Met Ala Gln 
    770                 775                 780                 


Val Gln Val Leu Leu Tyr Tyr Leu Gln His Pro Pro Ile Ser Phe Ala 
785                 790                 795                 800 


Glu Leu Lys Arg Asn Xaa Leu Tyr Phe Ser Xaa Asp Val 
                805                 810             


<210> 1333
<211> 168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<400> 1333
Met Arg Lys Leu Val Leu Ser Gly Phe Leu Ala Ser Glu Glu Ile Tyr 
1               5                   10                  15      


Ile Asn Gln Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys Ala 
            20                  25                  30          


Xaa Ala Xaa Xaa Ser Gln Pro Val Leu Xaa Ile Gln Gln Ile Glu Xaa 
        35                  40                  45              


Ile Phe Tyr Lys Ile Gln Asp Ile Tyr Glu Ile His Lys Glu Phe Tyr 
    50                  55                  60                  


Asp Asn Leu Cys Pro Lys Val Gln Gln Trp Asp Ser Gln Val Xaa Met 
65                  70                  75                  80  


Gly His Leu Phe Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Lys Ala 
                85                  90                  95      


Phe Val Asp Asn Tyr Lys Val Ala Leu Glu Xaa Ala Glu Lys Cys Ser 
            100                 105                 110         


Gln Ser Asn Asn Gln Phe Gln Lys Ile Ser Glu Glu Leu Lys Val Lys 
        115                 120                 125             


Gly Pro Lys Asp Ser Lys Asp Ser His Xaa Ser Val Xaa Met Glu Ala 
    130                 135                 140                 


Leu Leu Tyr Lys Pro Ile Asp Arg Val Xaa Arg Ser Xaa Leu Val Leu 
145                 150                 155                 160 


His Asp Leu Leu Lys His Xaa Pro 
                165             


<210> 1334
<211> 153
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<400> 1334
Met Xaa Asp Val Leu Pro Gln Pro Asp Cys Ser Pro Lys Ala Gly Arg 
1               5                   10                  15      


Glu Pro Leu Ala Leu Glu Glu Ser Gly Ser Lys Arg Pro Pro Asn Xaa 
            20                  25                  30          


Gly Ala Arg Leu Trp Gly Arg Val Arg Asn Lys Leu Leu Arg Asn Lys 
        35                  40                  45              


Leu Asp Pro Gln Xaa Val Glu Xaa Lys Asn Trp His Xaa Asp Val Ile 
    50                  55                  60                  


Glu Met Asn Gly Ile Lys Val Glu Phe Ser Met Lys Phe Xaa Ser Arg 
65                  70                  75                  80  


Asp Met Ser Leu Lys Arg Xaa Pro Ser Lys Lys Gln Xaa Gly Val Phe 
                85                  90                  95      


Gly Val Lys Ile Ser Val Val Xaa Lys Arg Glu Arg Ser Lys Val Pro 
            100                 105                 110         


Tyr Ile Val Arg Gln Cys Val Glu Glu Ala Val Arg Leu Leu Arg Lys 
        115                 120                 125             


His His Arg Leu Asn Gly Gly Gly Met His Met Pro Arg Trp Val Ser 
    130                 135                 140                 


Arg Val Ala Gly Arg Gln Leu Ser Ser 
145                 150             


<210> 1335
<211> 310
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<400> 1335
Met Xaa Asp Val Leu Pro Gln Pro Asp Cys Ser Pro Lys Ala Gly Arg 
1               5                   10                  15      


Glu Pro Leu Ala Leu Glu Glu Ser Gly Ser Lys Arg Pro Pro Asn Xaa 
            20                  25                  30          


Gly Ala Arg Leu Trp Gly Arg Val Arg Asn Lys Leu Leu Arg Asn Lys 
        35                  40                  45              


Leu Asp Pro Gln Xaa Val Glu Xaa Lys Asn Trp His Xaa Asp Val Ile 
    50                  55                  60                  


Glu Met Asn Gly Ile Lys Val Glu Phe Ser Met Lys Phe Xaa Ser Arg 
65                  70                  75                  80  


Asp Met Ser Leu Lys Arg Xaa Pro Ser Lys Lys Gln Xaa Gly Val Phe 
                85                  90                  95      


Gly Val Lys Ile Ser Val Val Xaa Lys Arg Glu Arg Ser Lys Val Pro 
            100                 105                 110         


Tyr Ile Val Arg Gln Cys Val Glu Glu Val Glu Lys Arg Gly Ile Glu 
        115                 120                 125             


Glu Val Gly Ile Tyr Arg Ile Ser Gly Val Ala Xaa Asp Ile Gln Ala 
    130                 135                 140                 


Leu Lys Ala Val Phe Asp Ala Asn Asn Lys Asp Ile Leu Leu Met Leu 
145                 150                 155                 160 


Ser Asp Met Asp Ile Asn Ala Ile Ala Gly Xaa Leu Lys Leu Tyr Phe 
                165                 170                 175     


Arg Glu Leu Pro Glu Pro Leu Leu Xaa Asp Arg Leu Tyr Pro Ala Phe 
            180                 185                 190         


Met Glu Gly Ile Ala Leu Ser Asp Pro Ala Ala Lys Glu Asn Cys Met 
        195                 200                 205             


Met His Leu Leu Arg Ser Leu Pro Asp Pro Asn Leu Ile Xaa Phe Leu 
    210                 215                 220                 


Phe Leu Leu Glu His Leu Lys Arg Val Ala Glu Lys Glu Pro Ile Asn 
225                 230                 235                 240 


Lys Met Ser Leu His Asn Leu Ala Xaa Val Phe Gly Pro Xaa Leu Leu 
                245                 250                 255     


Arg Pro Ser Glu Val Glu Ser Lys Ala His Leu Xaa Ser Ala Ala Asp 
            260                 265                 270         


Ile Trp Ser His Asp Val Met Ala Gln Val Gln Val Leu Leu Tyr Tyr 
        275                 280                 285             


Leu Gln His Pro Pro Ile Ser Phe Ala Glu Leu Lys Arg Asn Xaa Leu 
    290                 295                 300                 


Tyr Phe Ser Xaa Asp Val 
305                 310 


<210> 1336
<211> 97
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<400> 1336
Pro Met Lys Pro Leu Lys Ala Xaa Ala Xaa Xaa Ser Gln Pro Val Leu 
1               5                   10                  15      


Xaa Ile Gln Gln Ile Glu Xaa Ile Phe Tyr Lys Ile Gln Asp Ile Tyr 
            20                  25                  30          


Glu Ile His Lys Glu Phe Tyr Asp Asn Leu Cys Pro Lys Val Gln Gln 
        35                  40                  45              


Trp Asp Ser Gln Val Xaa Met Gly His Leu Phe Gln Lys Leu Ala Ser 
    50                  55                  60                  


Gln Leu Gly Val Tyr Lys Ala Phe Val Asp Asn Tyr Lys Val Ala Leu 
65                  70                  75                  80  


Glu Xaa Ala Glu Lys Cys Ser Gln Ser Asn Asn Gln Phe Gln Lys Ile 
                85                  90                  95      


Ser 
    


<210> 1337
<211> 50
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 1337
Val Glu Ala Gly Lys Gly Leu Glu Met Arg Lys Leu Val Leu Ser Gly 
1               5                   10                  15      


Phe Leu Ala Ser Glu Glu Ile Tyr Ile Asn Gln Leu Glu Ala Leu Leu 
            20                  25                  30          


Leu Pro Met Lys Pro Leu Lys Ala Xaa Ala Xaa Xaa Ser Gln Pro Val 
        35                  40                  45              


Leu Xaa 
    50  


<210> 1338
<211> 52
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 1338
Val Glu Ala Gly Lys Gly Leu Glu Met Arg Lys Leu Val Leu Ser Gly 
1               5                   10                  15      


Phe Leu Ala Ser Glu Glu Ile Tyr Ile Asn Gln Leu Glu Ala Leu Leu 
            20                  25                  30          


Leu Pro Met Lys Pro Leu Lys Ala Xaa Ala Xaa Xaa Ser Gln Pro Val 
        35                  40                  45              


Leu Xaa Ile Gln 
    50          


<210> 1339
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<400> 1339
Val Glu Ala Gly Lys Gly Leu Glu Met Arg Lys Leu Val Leu Ser Gly 
1               5                   10                  15      


Phe Leu Ala Ser Glu Glu Ile Tyr Ile Asn Gln Leu Glu Ala Leu Leu 
            20                  25                  30          


Leu Pro Met Lys Pro Leu Lys Ala Xaa Ala Xaa Xaa Ser Gln Pro Val 
        35                  40                  45              


Leu Xaa Ile Gln Gln Ile Glu Xaa Ile Phe Tyr Lys Ile Gln Asp Ile 
    50                  55                  60                  


Tyr Glu Ile His Lys Glu Phe Tyr Asp Asn Leu Cys Pro Lys Val Gln 
65                  70                  75                  80  


Gln Trp Asp Ser Gln Val Xaa Met Gly His Leu Phe Gln 
                85                  90              


<210> 1340
<211> 777
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<400> 1340
Val Glu Ala Gly Lys Gly Leu Glu Met Arg Lys Leu Val Leu Ser Gly 
1               5                   10                  15      


Phe Leu Ala Ser Glu Glu Ile Tyr Ile Asn Gln Leu Glu Ala Leu Leu 
            20                  25                  30          


Leu Pro Met Lys Pro Leu Lys Ala Xaa Ala Xaa Xaa Ser Gln Pro Val 
        35                  40                  45              


Leu Xaa Ile Gln Gln Ile Glu Xaa Ile Phe Tyr Lys Ile Gln Asp Ile 
    50                  55                  60                  


Tyr Glu Ile His Lys Glu Phe Tyr Asp Asn Leu Cys Pro Lys Val Gln 
65                  70                  75                  80  


Gln Trp Asp Ser Gln Val Xaa Met Gly His Leu Phe Gln Lys Leu Ala 
                85                  90                  95      


Ser Gln Leu Gly Val Tyr Lys Ala Phe Val Asp Asn Tyr Lys Val Ala 
            100                 105                 110         


Leu Glu Xaa Ala Glu Lys Cys Ser Gln Ser Asn Asn Gln Phe Gln Lys 
        115                 120                 125             


Ile Ser Glu Glu Leu Lys Val Lys Gly Pro Lys Asp Ser Lys Asp Ser 
    130                 135                 140                 


His Xaa Ser Val Xaa Met Glu Ala Leu Leu Tyr Lys Pro Ile Asp Arg 
145                 150                 155                 160 


Val Xaa Arg Ser Xaa Leu Val Leu His Asp Leu Leu Lys His Xaa Pro 
                165                 170                 175     


Val Asp His Pro Asp Tyr Pro Leu Leu Gln Asp Ala Leu Arg Ile Ser 
            180                 185                 190         


Gln Asn Phe Leu Ser Ser Ile Asn Glu Asp Ile Asp Pro Arg Arg Xaa 
        195                 200                 205             


Ala Val Xaa Xaa Pro Lys Gly Glu Xaa Arg Gln Leu Val Lys Asp Gly 
    210                 215                 220                 


Phe Leu Val Glu Val Ser Glu Ser Ser Arg Lys Leu Arg His Val Phe 
225                 230                 235                 240 


Leu Phe Xaa Asp Val Leu Leu Cys Ala Lys Leu Lys Lys Xaa Ser Ala 
                245                 250                 255     


Gly Lys His Gln Gln Tyr Asp Cys Lys Trp Tyr Ile Pro Leu Ala Asp 
            260                 265                 270         


Leu Val Phe Pro Ser Pro Glu Glu Ser Glu Ala Ser Pro Gln Val His 
        275                 280                 285             


Pro Phe Pro Asp His Glu Leu Glu Asp Met Lys Met Lys Ile Ser Ala 
    290                 295                 300                 


Leu Lys Ser Glu Ile Gln Lys Glu Lys Ala Asn Lys Gly Gln Ser Arg 
305                 310                 315                 320 


Ala Ile Glu Arg Leu Lys Lys Lys Met Phe Glu Asn Glu Phe Leu Leu 
                325                 330                 335     


Leu Leu Asn Ser Pro Xaa Ile Pro Phe Arg Ile His Asn Arg Asn Gly 
            340                 345                 350         


Lys Ser Tyr Leu Phe Leu Leu Ser Ser Asp Tyr Glu Arg Ser Glu Trp 
        355                 360                 365             


Arg Glu Ala Ile Gln Lys Leu Gln Lys Lys Asp Leu Gln Ala Phe Val 
    370                 375                 380                 


Leu Ser Ser Val Glu Leu Gln Val Leu Xaa Gly Ser Cys Phe Lys Leu 
385                 390                 395                 400 


Arg Xaa Val His Asn Ile Pro Val Xaa Ser Asn Lys Asp Asp Asp Glu 
                405                 410                 415     


Ser Pro Gly Leu Tyr Gly Phe Leu His Val Ile Val His Ser Ala Lys 
            420                 425                 430         


Gly Phe Lys Gln Ser Ala Asn Leu Tyr Cys Xaa Leu Glu Val Asp Ser 
        435                 440                 445             


Phe Gly Tyr Phe Val Ser Lys Ala Lys Xaa Arg Val Phe Arg Asp Xaa 
    450                 455                 460                 


Ala Glu Pro Lys Trp Asp Glu Glu Phe Glu Ile Glu Leu Glu Gly Ser 
465                 470                 475                 480 


Gln Ser Leu Arg Ile Leu Cys Tyr Glu Lys Cys Tyr Asp Lys Xaa Lys 
                485                 490                 495     


Val Asn Lys Asp Asn Asn Glu Ile Val Asp Lys Ile Met Gly Lys Gly 
            500                 505                 510         


Gln Ile Gln Leu Asp Pro Gln Xaa Val Glu Xaa Lys Asn Trp His Xaa 
        515                 520                 525             


Asp Val Ile Glu Met Asn Gly Ile Lys Val Glu Phe Ser Met Lys Phe 
    530                 535                 540                 


Xaa Ser Arg Asp Met Ser Leu Lys Arg Xaa Pro Ser Lys Lys Gln Xaa 
545                 550                 555                 560 


Gly Val Phe Gly Val Lys Ile Ser Val Val Xaa Lys Arg Glu Arg Ser 
                565                 570                 575     


Lys Val Pro Tyr Ile Val Arg Gln Cys Val Glu Glu Val Glu Lys Arg 
            580                 585                 590         


Gly Ile Glu Glu Val Gly Ile Tyr Arg Ile Ser Gly Val Ala Xaa Asp 
        595                 600                 605             


Ile Gln Ala Leu Lys Ala Val Phe Asp Ala Asn Asn Lys Asp Ile Leu 
    610                 615                 620                 


Leu Met Leu Ser Asp Met Asp Ile Asn Ala Ile Ala Gly Xaa Leu Lys 
625                 630                 635                 640 


Leu Tyr Phe Arg Glu Leu Pro Glu Pro Leu Leu Xaa Asp Arg Leu Tyr 
                645                 650                 655     


Pro Ala Phe Met Glu Gly Ile Ala Leu Ser Asp Pro Ala Ala Lys Glu 
            660                 665                 670         


Asn Cys Met Met His Leu Leu Arg Ser Leu Pro Asp Pro Asn Leu Ile 
        675                 680                 685             


Xaa Phe Leu Phe Leu Leu Glu His Leu Lys Arg Val Ala Glu Lys Glu 
    690                 695                 700                 


Pro Ile Asn Lys Met Ser Leu His Asn Leu Ala Xaa Val Phe Gly Pro 
705                 710                 715                 720 


Xaa Leu Leu Arg Pro Ser Glu Val Glu Ser Lys Ala His Leu Xaa Ser 
                725                 730                 735     


Ala Ala Asp Ile Trp Ser His Asp Val Met Ala Gln Val Gln Val Leu 
            740                 745                 750         


Leu Tyr Tyr Leu Gln His Pro Pro Ile Ser Phe Ala Glu Leu Lys Arg 
        755                 760                 765             


Asn Xaa Leu Tyr Phe Ser Xaa Asp Val 
    770                 775         


<210> 1341
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<400> 1341
Xaa Glu Glu Val Gly Ile Tyr Arg Ile Ser Gly Val Ala Xaa Asp Ile 
1               5                   10                  15      


Gln Ala Leu Lys Ala Val Phe Asp Ala Asn Asn Lys Asp Ile Leu Leu 
            20                  25                  30          


Met Leu Ser Asp Met Asp Ile Asn Ala Ile Ala Gly Xaa Leu Lys Leu 
        35                  40                  45              


Tyr Phe Arg Glu Leu Pro Glu Pro Leu Leu Xaa Asp Arg Leu Tyr Pro 
    50                  55                  60                  


Ala Phe Met Glu Gly Ile Ala Leu Ser Asp Pro Ala Ala Lys Glu Asn 
65                  70                  75                  80  


Cys Met Met His Leu Leu Arg Ser Leu Pro Asp Pro Asn Leu Ile Xaa 
                85                  90                  95      


Phe Leu Phe Leu Leu Glu His Leu Lys Arg Val Ala Glu Lys Glu Pro 
            100                 105                 110         


Ile Asn Lys Met Ser Leu His Asn Leu Ala Xaa Val Phe Gly Pro Xaa 
        115                 120                 125             


Leu Leu Arg Pro Ser Glu Val Glu Ser Lys Ala His Leu Xaa Ser Ala 
    130                 135                 140                 


Ala Asp Ile Trp Ser His Asp Val Met Ala Gln Asn Ser Ser Gly Xaa 
145                 150                 155                 160 


His Cys Xaa Ser Pro Pro Xaa Cys Ser Pro Arg Gln Gly Gly Cys Gly 
                165                 170                 175     


Arg Val Val Glu Pro Ala Pro Pro Ala Trp Gly Pro Xaa Gln Xaa 
            180                 185                 190     


<210> 1342
<211> 189
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<400> 1342
Xaa Lys Xaa Ser Ala Gly Lys His Gln Gln Tyr Asp Cys Lys Trp Tyr 
1               5                   10                  15      


Ile Pro Leu Ala Asp Leu Val Phe Pro Ser Pro Glu Glu Ser Glu Ala 
            20                  25                  30          


Ser Pro Gln Val His Pro Phe Pro Asp His Glu Leu Glu Asp Met Lys 
        35                  40                  45              


Met Lys Ile Ser Ala Leu Lys Ser Glu Ile Gln Lys Glu Lys Ala Asn 
    50                  55                  60                  


Lys Gly Gln Ser Arg Ala Ile Glu Arg Leu Lys Lys Lys Met Phe Glu 
65                  70                  75                  80  


Asn Glu Phe Leu Leu Leu Leu Asn Ser Pro Xaa Ile Pro Phe Arg Ile 
                85                  90                  95      


His Asn Arg Asn Gly Lys Ser Tyr Leu Phe Leu Leu Ser Ser Asp Tyr 
            100                 105                 110         


Glu Arg Ser Glu Trp Arg Glu Ala Ile Gln Lys Leu Gln Lys Lys Asp 
        115                 120                 125             


Leu Gln Ala Phe Val Leu Ser Ser Val Glu Leu Gln Val Leu Xaa Gly 
    130                 135                 140                 


Ser Cys Phe Lys Leu Arg Xaa Val His Asn Ile Pro Val Xaa Ser Asn 
145                 150                 155                 160 


Lys Asp Asp Leu Tyr Cys Xaa Leu Glu Val Asp Ser Phe Gly Tyr Phe 
                165                 170                 175     


Val Ser Lys Ala Lys Xaa Arg Val Phe Arg Asp Xaa Ala 
            180                 185                 


<210> 1343
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 1343
Xaa Arg Asp Xaa Ala Glu Pro Lys Trp Asp Glu Glu Phe Glu Ile Glu 
1               5                   10                  15      


Leu Glu Gly Ser Gln Ser Leu Arg Ile Leu Cys Tyr Glu Lys Cys Tyr 
            20                  25                  30          


Asp Lys Xaa Lys Val Asn Lys Asp Asn Asn Glu Ile Val Asp Lys Ile 
        35                  40                  45              


Met Gly Lys Gly Gln Ile Gln Leu Asp Pro Gln Xaa Val Glu Xaa Lys 
    50                  55                  60                  


Asn Trp His Xaa Asp Val Ile Glu Met Asn Gly Ile Lys Val Glu Phe 
65                  70                  75                  80  


Ser Met Lys Phe Xaa Ser Arg Asp Met Ser Leu Lys Arg Xaa Pro Ser 
                85                  90                  95      


Lys Lys Gln Xaa Gly Val Phe Gly Val Lys Ile Ser Val Val Xaa Lys 
            100                 105                 110         


Trp Pro Val Trp Ile 
        115         


<210> 1344
<211> 381
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<400> 1344
Met Ala Pro Gly Glu Lys Glu Ser Gly Glu Gly Pro Ala Lys Ser Ala 
1               5                   10                  15      


Leu Arg Lys Ile Arg Xaa Ala Xaa Leu Val Ile Ser Leu Ala Arg Gly 
            20                  25                  30          


Trp Gln Gln Trp Ala Asn Glu Asn Ser Ile Arg Gln Ala Gln Glu Pro 
        35                  40                  45              


Xaa Gly Trp Leu Pro Gly Gly Xaa Gln Asp Ser Pro Gln Ala Pro Lys 
    50                  55                  60                  


Pro Ile Xaa Pro Pro Xaa Ser His Gln Lys Ala Gln Ser Ala Pro Lys 
65                  70                  75                  80  


Ser Pro Pro Arg Leu Pro Glu Gly His Gly Asp Gly Gln Ser Ser Glu 
                85                  90                  95      


Lys Ala Pro Glu Val Ser His Ile Lys Lys Lys Glu Val Ser Lys Xaa 
            100                 105                 110         


Val Val Ser Lys Xaa Tyr Glu Arg Gly Gly Asp Val Ser His Leu Ser 
        115                 120                 125             


His Arg Tyr Glu Arg Asp Ala Gly Val Leu Glu Pro Gly Gln Pro Glu 
    130                 135                 140                 


Asn Asp Ile Asp Arg Ile Leu His Ser His Gly Ser Pro Xaa Arg Arg 
145                 150                 155                 160 


Arg Lys Cys Ala Asn Leu Val Ser Glu Leu Xaa Lys Gly Trp Arg Val 
                165                 170                 175     


Met Glu Gln Glu Glu Pro Xaa Trp Arg Ser Asp Ser Val Asp Xaa Glu 
            180                 185                 190         


Asp Ser Gly Tyr Gly Gly Glu Ala Glu Glu Arg Pro Glu Gln Asp Gly 
        195                 200                 205             


Val Gln Val Ala Val Val Arg Ile Lys Arg Pro Leu Pro Ser Gln Val 
    210                 215                 220                 


Asn Arg Phe Xaa Glu Lys Leu Asn Cys Lys Ala Gln Gln Lys Tyr Ser 
225                 230                 235                 240 


Pro Val Gly Asn Leu Lys Gly Arg Trp Gln Gln Trp Ala Asp Glu His 
                245                 250                 255     


Ile Gln Ser Gln Lys Leu Asn Pro Phe Ser Glu Glu Phe Asp Tyr Glu 
            260                 265                 270         


Leu Ala Met Ser Xaa Arg Leu His Lys Gly Asp Glu Gly Tyr Gly Arg 
        275                 280                 285             


Pro Lys Glu Gly Xaa Lys Xaa Ala Glu Arg Ala Lys Arg Ala Glu Glu 
    290                 295                 300                 


His Ile Tyr Arg Glu Met Met Asp Met Cys Phe Ile Ile Cys Xaa Met 
305                 310                 315                 320 


Ala Arg His Arg Arg Asp Gly Lys Ile Gln Val Xaa Phe Gly Asp Leu 
                325                 330                 335     


Phe Asp Arg Tyr Val Arg Ile Ser Asp Lys Val Val Gly Ile Leu Met 
            340                 345                 350         


Arg Ala Arg Lys His Gly Leu Val Asp Phe Glu Gly Glu Met Leu Trp 
        355                 360                 365             


Gln Gly Arg Asp Asp His Val Val Ile Xaa Leu Leu Lys 
    370                 375                 380     


<210> 1345
<211> 397
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<400> 1345
Met Ala Leu Leu Arg Gly Val Phe Val Val Ala Ala Lys Arg Xaa Pro 
1               5                   10                  15      


Phe Gly Ala Tyr Gly Gly Leu Leu Lys Asp Phe Xaa Ala Xaa Asp Leu 
            20                  25                  30          


Ser Glu Phe Ala Ala Lys Ala Ala Leu Ser Ala Gly Lys Val Ser Pro 
        35                  40                  45              


Glu Xaa Val Asp Ser Val Ile Met Gly Asn Val Leu Gln Ser Ser Ser 
    50                  55                  60                  


Asp Ala Ile Tyr Leu Ala Arg His Val Gly Leu Arg Val Gly Ile Pro 
65                  70                  75                  80  


Lys Glu Xaa Pro Ala Leu Xaa Ile Asn Arg Leu Cys Gly Ser Gly Phe 
                85                  90                  95      


Gln Ser Ile Val Asn Gly Cys Gln Glu Ile Cys Val Lys Glu Ala Glu 
            100                 105                 110         


Val Val Leu Cys Gly Gly Xaa Glu Ser Met Ser Gln Ala Pro Tyr Cys 
        115                 120                 125             


Val Arg Asn Val Arg Phe Gly Xaa Lys Leu Gly Ser Asp Ile Lys Leu 
    130                 135                 140                 


Glu Asp Ser Leu Trp Val Ser Leu Xaa Asp Gln His Val Gln Leu Pro 
145                 150                 155                 160 


Met Ala Met Xaa Ala Glu Asn Leu Ala Val Lys His Lys Ile Ser Arg 
                165                 170                 175     


Glu Glu Cys Asp Lys Tyr Ala Leu Gln Ser Gln Gln Arg Trp Lys Ala 
            180                 185                 190         


Ala Asn Asp Ala Gly Tyr Phe Asn Asp Glu Met Ala Pro Ile Glu Val 
        195                 200                 205             


Lys Xaa Lys Lys Gly Lys Gln Xaa Met Gln Val Asp Glu His Ala Arg 
    210                 215                 220                 


Pro Gln Xaa Xaa Leu Glu Gln Leu Gln Lys Leu Pro Pro Val Phe Lys 
225                 230                 235                 240 


Lys Asp Gly Xaa Val Xaa Ala Gly Asn Ala Ser Gly Val Ala Asp Gly 
                245                 250                 255     


Ala Gly Ala Val Ile Ile Ala Ser Glu Asp Ala Val Lys Lys His Asn 
            260                 265                 270         


Phe Xaa Pro Leu Ala Arg Ile Val Gly Tyr Phe Val Ser Gly Cys Asp 
        275                 280                 285             


Pro Ser Ile Met Gly Ile Gly Pro Val Pro Ala Ile Ser Gly Ala Leu 
    290                 295                 300                 


Lys Lys Ala Gly Leu Ser Leu Lys Asp Met Asp Leu Val Glu Val Asn 
305                 310                 315                 320 


Glu Ala Phe Ala Pro Gln Tyr Leu Ala Val Glu Arg Ser Leu Asp Leu 
                325                 330                 335     


Asp Ile Ser Lys Xaa Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His 
            340                 345                 350         


Pro Leu Gly Gly Ser Gly Ser Arg Ile Xaa Ala His Leu Val His Glu 
        355                 360                 365             


Leu Arg Arg Arg Gly Gly Lys Tyr Ala Val Gly Ser Ala Cys Ile Gly 
    370                 375                 380                 


Gly Gly Gln Gly Ile Ala Val Ile Ile Gln Ser Xaa Ala 
385                 390                 395         


<210> 1346
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 1346
Met Gly Asn Val Leu Gln Ser Ser Ser Asp Ala Ile Tyr Leu Ala Arg 
1               5                   10                  15      


His Val Gly Leu Arg Val Gly Ile Pro Lys Glu Xaa Pro Ala Leu Xaa 
            20                  25                  30          


Ile Asn Arg Leu Cys Gly Ser Gly Phe Gln Ser Ile Val Asn Gly Cys 
        35                  40                  45              


Gln Glu Ile Cys Val Lys Glu Ala Glu Val Val Leu Cys Gly Gly Xaa 
    50                  55                  60                  


Glu Ser Met Ser Gln Ala Pro Tyr 
65                  70          


<210> 1347
<211> 84
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 1347
Met Gly Asn Val Leu Gln Ser Ser Ser Asp Ala Ile Tyr Leu Ala Arg 
1               5                   10                  15      


His Val Gly Leu Arg Val Gly Ile Pro Lys Glu Xaa Pro Ala Leu Xaa 
            20                  25                  30          


Ile Asn Arg Leu Cys Gly Ser Gly Phe Gln Ser Ile Val Asn Gly Cys 
        35                  40                  45              


Gln Glu Ile Cys Val Lys Glu Ala Glu Val Val Leu Cys Gly Gly Xaa 
    50                  55                  60                  


Glu Ser Met Ser Gln Ala Pro Tyr Cys Val Arg Asn Val Arg Phe Gly 
65                  70                  75                  80  


Xaa Lys Leu Gly 
                


<210> 1348
<211> 124
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<400> 1348
Met Gly Asn Val Leu Gln Ser Ser Ser Asp Ala Ile Tyr Leu Ala Arg 
1               5                   10                  15      


His Val Gly Leu Arg Val Gly Ile Pro Lys Glu Xaa Pro Ala Leu Xaa 
            20                  25                  30          


Ile Asn Arg Leu Cys Gly Ser Gly Phe Gln Ser Ile Val Asn Gly Cys 
        35                  40                  45              


Gln Glu Ile Cys Val Lys Glu Ala Glu Val Val Leu Cys Gly Gly Xaa 
    50                  55                  60                  


Glu Ser Met Ser Gln Ala Pro Tyr Cys Val Arg Asn Val Arg Phe Gly 
65                  70                  75                  80  


Xaa Lys Leu Gly Ser Asp Ile Lys Leu Glu Asp Ser Leu Trp Val Ser 
                85                  90                  95      


Leu Xaa Asp Gln His Val Gln Leu Pro Met Ala Met Xaa Ala Glu Asn 
            100                 105                 110         


Leu Ala Val Lys His Lys Ile Ser Arg Glu Glu Cys 
        115                 120                 


<210> 1349
<211> 342
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<400> 1349
Met Gly Asn Val Leu Gln Ser Ser Ser Asp Ala Ile Tyr Leu Ala Arg 
1               5                   10                  15      


His Val Gly Leu Arg Val Gly Ile Pro Lys Glu Xaa Pro Ala Leu Xaa 
            20                  25                  30          


Ile Asn Arg Leu Cys Gly Ser Gly Phe Gln Ser Ile Val Asn Gly Cys 
        35                  40                  45              


Gln Glu Ile Cys Val Lys Glu Ala Glu Val Val Leu Cys Gly Gly Xaa 
    50                  55                  60                  


Glu Ser Met Ser Gln Ala Pro Tyr Cys Val Arg Asn Val Arg Phe Gly 
65                  70                  75                  80  


Xaa Lys Leu Gly Ser Asp Ile Lys Leu Glu Asp Ser Leu Trp Val Ser 
                85                  90                  95      


Leu Xaa Asp Gln His Val Gln Leu Pro Met Ala Met Xaa Ala Glu Asn 
            100                 105                 110         


Leu Ala Val Lys His Lys Ile Ser Arg Glu Glu Cys Asp Lys Tyr Ala 
        115                 120                 125             


Leu Gln Ser Gln Gln Arg Trp Lys Ala Ala Asn Asp Ala Gly Tyr Phe 
    130                 135                 140                 


Asn Asp Glu Met Ala Pro Ile Glu Val Lys Xaa Lys Lys Gly Lys Gln 
145                 150                 155                 160 


Xaa Met Gln Val Asp Glu His Ala Arg Pro Gln Xaa Xaa Leu Glu Gln 
                165                 170                 175     


Leu Gln Lys Leu Pro Pro Val Phe Lys Lys Asp Gly Xaa Val Xaa Ala 
            180                 185                 190         


Gly Asn Ala Ser Gly Val Ala Asp Gly Ala Gly Ala Val Ile Ile Ala 
        195                 200                 205             


Ser Glu Asp Ala Val Lys Lys His Asn Phe Xaa Pro Leu Ala Arg Ile 
    210                 215                 220                 


Val Gly Tyr Phe Val Ser Gly Cys Asp Pro Ser Ile Met Gly Ile Gly 
225                 230                 235                 240 


Pro Val Pro Ala Ile Ser Gly Ala Leu Lys Lys Ala Gly Leu Ser Leu 
                245                 250                 255     


Lys Asp Met Asp Leu Val Glu Val Asn Glu Ala Phe Ala Pro Gln Tyr 
            260                 265                 270         


Leu Ala Val Glu Arg Ser Leu Asp Leu Asp Ile Ser Lys Xaa Asn Val 
        275                 280                 285             


Asn Gly Gly Ala Ile Ala Leu Gly His Pro Leu Gly Gly Ser Gly Ser 
    290                 295                 300                 


Arg Ile Xaa Ala His Leu Val His Glu Leu Arg Arg Arg Gly Gly Lys 
305                 310                 315                 320 


Tyr Ala Val Gly Ser Ala Cys Ile Gly Gly Gly Gln Gly Ile Ala Val 
                325                 330                 335     


Ile Ile Gln Ser Xaa Ala 
            340         


<210> 1350
<211> 394
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<400> 1350
Met Met Gly Val Phe Val Val Ala Ala Lys Arg Xaa Pro Phe Gly Ala 
1               5                   10                  15      


Tyr Gly Gly Leu Leu Lys Asp Phe Xaa Ala Xaa Asp Leu Ser Glu Phe 
            20                  25                  30          


Ala Ala Lys Ala Ala Leu Ser Ala Gly Lys Val Ser Pro Glu Xaa Val 
        35                  40                  45              


Asp Ser Val Ile Met Gly Asn Val Leu Gln Ser Ser Ser Asp Ala Ile 
    50                  55                  60                  


Tyr Leu Ala Arg His Val Gly Leu Arg Val Gly Ile Pro Lys Glu Xaa 
65                  70                  75                  80  


Pro Ala Leu Xaa Ile Asn Arg Leu Cys Gly Ser Gly Phe Gln Ser Ile 
                85                  90                  95      


Val Asn Gly Cys Gln Glu Ile Cys Val Lys Glu Ala Glu Val Val Leu 
            100                 105                 110         


Cys Gly Gly Xaa Glu Ser Met Ser Gln Ala Pro Tyr Cys Val Arg Asn 
        115                 120                 125             


Val Arg Phe Gly Xaa Lys Leu Gly Ser Asp Ile Lys Leu Glu Asp Ser 
    130                 135                 140                 


Leu Trp Val Ser Leu Xaa Asp Gln His Val Gln Leu Pro Met Ala Met 
145                 150                 155                 160 


Xaa Ala Glu Asn Leu Ala Val Lys His Lys Ile Ser Arg Glu Glu Cys 
                165                 170                 175     


Asp Lys Tyr Ala Leu Gln Ser Gln Gln Arg Trp Lys Ala Ala Asn Asp 
            180                 185                 190         


Ala Gly Tyr Phe Asn Asp Glu Met Ala Pro Ile Glu Val Lys Xaa Lys 
        195                 200                 205             


Lys Gly Lys Gln Xaa Met Gln Val Asp Glu His Ala Arg Pro Gln Xaa 
    210                 215                 220                 


Xaa Leu Glu Gln Leu Gln Lys Leu Pro Pro Val Phe Lys Lys Asp Gly 
225                 230                 235                 240 


Xaa Val Xaa Ala Gly Asn Ala Ser Gly Val Ala Asp Gly Ala Gly Ala 
                245                 250                 255     


Val Ile Ile Ala Ser Glu Asp Ala Val Lys Lys His Asn Phe Xaa Pro 
            260                 265                 270         


Leu Ala Arg Ile Val Gly Tyr Phe Val Ser Gly Cys Asp Pro Ser Ile 
        275                 280                 285             


Met Gly Ile Gly Pro Val Pro Ala Ile Ser Gly Ala Leu Lys Lys Ala 
    290                 295                 300                 


Gly Leu Ser Leu Lys Asp Met Asp Leu Val Glu Val Asn Glu Ala Phe 
305                 310                 315                 320 


Ala Pro Gln Tyr Leu Ala Val Glu Arg Ser Leu Asp Leu Asp Ile Ser 
                325                 330                 335     


Lys Xaa Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Leu Gly 
            340                 345                 350         


Gly Ser Gly Ser Arg Ile Xaa Ala His Leu Val His Glu Leu Arg Arg 
        355                 360                 365             


Arg Gly Gly Lys Tyr Ala Val Gly Ser Ala Cys Ile Gly Gly Gly Gln 
    370                 375                 380                 


Gly Ile Ala Val Ile Ile Gln Ser Xaa Ala 
385                 390                 


<210> 1351
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<400> 1351
Met Ala Ser Ser Gly Tyr Val Leu Gln Ala Glu Leu Ser Pro Ser Xaa 
1               5                   10                  15      


Glu Asn Ser Ser Gln Leu Asp Phe Glu Asp Val Trp Asn Ser Ser Tyr 
            20                  25                  30          


Gly Val Asn Asp Ser Phe Pro Asp Gly Asp Tyr Gly Ala Asn Leu Glu 
        35                  40                  45              


Ala Ala Ala Pro Cys His Ser Cys Asn Leu Leu Asp Asp Ser Ala Leu 
    50                  55                  60                  


Pro Phe Phe Ile Leu Xaa Ser Val Leu Gly Ile Leu Ala Ser Ser Xaa 
65                  70                  75                  80  


Val Leu Phe Met Leu Phe Arg Pro Leu Phe Arg Trp Gln Leu Cys Pro 
                85                  90                  95      


Gly Trp Pro Val Leu Ala Gln Leu Ala Val Gly Ser Ala Leu Phe Ser 
            100                 105                 110         


Ile Val Val Pro Val Leu Ala Pro Gly Leu Gly Ser Xaa Arg Ser Ser 
        115                 120                 125             


Ala Leu Cys Ser Leu Gly Tyr Cys Val Trp Tyr Gly Ser Ala Phe Ala 
    130                 135                 140                 


Gln Ala Leu Leu Leu Gly Cys His Ala Ser Leu 
145                 150                 155 


<210> 1352
<211> 338
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<400> 1352
Met Ala Ser Ser Gly Tyr Val Leu Gln Ala Glu Leu Ser Pro Ser Xaa 
1               5                   10                  15      


Glu Asn Ser Ser Gln Leu Asp Phe Glu Asp Val Trp Asn Ser Ser Tyr 
            20                  25                  30          


Gly Val Asn Asp Ser Phe Pro Asp Gly Asp Tyr Gly Ala Asn Leu Glu 
        35                  40                  45              


Ala Ala Ala Pro Cys His Ser Cys Asn Leu Leu Asp Asp Ser Ala Leu 
    50                  55                  60                  


Pro Phe Phe Ile Leu Xaa Ser Val Leu Gly Ile Leu Ala Ser Ser Xaa 
65                  70                  75                  80  


Val Leu Phe Met Leu Phe Arg Pro Leu Phe Arg Trp Gln Leu Cys Pro 
                85                  90                  95      


Gly Trp Pro Val Leu Ala Gln Leu Ala Val Gly Ser Ala Leu Phe Ser 
            100                 105                 110         


Ile Val Val Pro Val Leu Ala Pro Gly Leu Gly Ser Xaa Arg Ser Ser 
        115                 120                 125             


Ala Leu Cys Ser Leu Gly Tyr Cys Val Trp Tyr Gly Ser Ala Phe Ala 
    130                 135                 140                 


Gln Ala Leu Leu Leu Gly Cys His Ala Ser Leu Gly His Arg Leu Gly 
145                 150                 155                 160 


Ala Gly Gln Val Pro Gly Leu Xaa Leu Gly Leu Xaa Val Gly Ile Trp 
                165                 170                 175     


Gly Val Ala Ala Leu Leu Xaa Leu Pro Val Xaa Leu Ala Ser Gly Ala 
            180                 185                 190         


Ser Gly Gly Leu Cys Xaa Leu Ile Tyr Ser Xaa Glu Leu Lys Ala Leu 
        195                 200                 205             


Gln Ala Xaa His Xaa Val Ala Cys Leu Ala Ile Phe Val Leu Leu Pro 
    210                 215                 220                 


Leu Gly Leu Phe Gly Ala Lys Gly Leu Lys Lys Ala Leu Gly Met Gly 
225                 230                 235                 240 


Pro Gly Pro Trp Met Asn Ile Leu Trp Ala Trp Phe Ile Phe Trp Trp 
                245                 250                 255     


Pro His Gly Val Val Leu Gly Leu Asp Phe Leu Val Arg Ser Lys Leu 
            260                 265                 270         


Leu Leu Leu Ser Xaa Cys Leu Ala Gln Gln Ala Leu Asp Leu Leu Leu 
        275                 280                 285             


Asn Leu Ala Glu Ala Leu Ala Ile Leu His Cys Val Ala Xaa Pro Leu 
    290                 295                 300                 


Leu Leu Ala Leu Phe Cys His Gln Ala Xaa Arg Xaa Leu Leu Pro Ser 
305                 310                 315                 320 


Leu Pro Leu Pro Glu Gly Trp Ser Ser His Leu Asp Xaa Leu Gly Ser 
                325                 330                 335     


Lys Ser 
        


<210> 1353
<211> 336
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<400> 1353
Met Gly Asn Cys Leu His Arg Ala Glu Leu Ser Pro Ser Xaa Glu Asn 
1               5                   10                  15      


Ser Ser Gln Leu Asp Phe Glu Asp Val Trp Asn Ser Ser Tyr Gly Val 
            20                  25                  30          


Asn Asp Ser Phe Pro Asp Gly Asp Tyr Gly Ala Asn Leu Glu Ala Ala 
        35                  40                  45              


Ala Pro Cys His Ser Cys Asn Leu Leu Asp Asp Ser Ala Leu Pro Phe 
    50                  55                  60                  


Phe Ile Leu Xaa Ser Val Leu Gly Ile Leu Ala Ser Ser Xaa Val Leu 
65                  70                  75                  80  


Phe Met Leu Phe Arg Pro Leu Phe Arg Trp Gln Leu Cys Pro Gly Trp 
                85                  90                  95      


Pro Val Leu Ala Gln Leu Ala Val Gly Ser Ala Leu Phe Ser Ile Val 
            100                 105                 110         


Val Pro Val Leu Ala Pro Gly Leu Gly Ser Xaa Arg Ser Ser Ala Leu 
        115                 120                 125             


Cys Ser Leu Gly Tyr Cys Val Trp Tyr Gly Ser Ala Phe Ala Gln Ala 
    130                 135                 140                 


Leu Leu Leu Gly Cys His Ala Ser Leu Gly His Arg Leu Gly Ala Gly 
145                 150                 155                 160 


Gln Val Pro Gly Leu Xaa Leu Gly Leu Xaa Val Gly Ile Trp Gly Val 
                165                 170                 175     


Ala Ala Leu Leu Xaa Leu Pro Val Xaa Leu Ala Ser Gly Ala Ser Gly 
            180                 185                 190         


Gly Leu Cys Xaa Leu Ile Tyr Ser Xaa Glu Leu Lys Ala Leu Gln Ala 
        195                 200                 205             


Xaa His Xaa Val Ala Cys Leu Ala Ile Phe Val Leu Leu Pro Leu Gly 
    210                 215                 220                 


Leu Phe Gly Ala Lys Gly Leu Lys Lys Ala Leu Gly Met Gly Pro Gly 
225                 230                 235                 240 


Pro Trp Met Asn Ile Leu Trp Ala Trp Phe Ile Phe Trp Trp Pro His 
                245                 250                 255     


Gly Val Val Leu Gly Leu Asp Phe Leu Val Arg Ser Lys Leu Leu Leu 
            260                 265                 270         


Leu Ser Xaa Cys Leu Ala Gln Gln Ala Leu Asp Leu Leu Leu Asn Leu 
        275                 280                 285             


Ala Glu Ala Leu Ala Ile Leu His Cys Val Ala Xaa Pro Leu Leu Leu 
    290                 295                 300                 


Ala Leu Phe Cys His Gln Ala Xaa Arg Xaa Leu Leu Pro Ser Leu Pro 
305                 310                 315                 320 


Leu Pro Glu Gly Trp Ser Ser His Leu Asp Xaa Leu Gly Ser Lys Ser 
                325                 330                 335     


<210> 1354
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<400> 1354
Met Ala Ala Xaa Ala Ser Pro Gln Pro Leu Ala Xaa Glu Asp Ala Asp 
1               5                   10                  15      


Ser Glu Asn Ser Ser Phe Tyr Tyr Tyr Asp Tyr Leu Asp Glu Val Ala 
            20                  25                  30          


Phe Met Leu Cys Arg Lys Asp Ala Val Val Ser Phe Gly Lys Val Phe 
        35                  40                  45              


Leu Pro Val Phe Tyr Ser Leu Ile Phe Val Leu Gly Leu Ser Gly Asn 
    50                  55                  60                  


Leu Leu Leu Leu Met Val Leu Leu Arg Tyr Val Pro Arg Arg Arg Met 
65                  70                  75                  80  


Val Glu Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asn Leu Leu Phe Leu 
                85                  90                  95      


Val Xaa Leu Pro Phe Trp Gly Ile Ser Val Ala Trp His Trp Val Phe 
            100                 105                 110         


Gly Ser Phe Leu Cys Lys Met Val Ser Xaa Leu Tyr Xaa 
        115                 120                 125 


<210> 1355
<211> 142
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<400> 1355
Met Ala Ala Xaa Ala Ser Pro Gln Pro Leu Ala Xaa Glu Asp Ala Asp 
1               5                   10                  15      


Ser Glu Asn Ser Ser Phe Tyr Tyr Tyr Asp Tyr Leu Asp Glu Val Ala 
            20                  25                  30          


Phe Met Leu Cys Arg Lys Asp Ala Val Val Ser Phe Gly Lys Val Phe 
        35                  40                  45              


Leu Pro Val Phe Tyr Ser Leu Ile Phe Val Leu Gly Leu Ser Gly Asn 
    50                  55                  60                  


Leu Leu Leu Leu Met Val Leu Leu Arg Tyr Val Pro Arg Arg Arg Met 
65                  70                  75                  80  


Val Glu Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asn Leu Leu Phe Leu 
                85                  90                  95      


Val Xaa Leu Pro Phe Trp Gly Ile Ser Val Ala Trp His Trp Val Phe 
            100                 105                 110         


Gly Ser Phe Leu Cys Lys Met Val Ser Xaa Leu Tyr Xaa Ile Asn Phe 
        115                 120                 125             


Tyr Ser Gly Ile Phe Phe Ile Ser Cys Met Ser Leu Asp Lys 
    130                 135                 140         


<210> 1356
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 1356
Met Ala Ala Xaa Ala Ser Pro Gln Pro Leu Ala Xaa Glu Asp Ala Asp 
1               5                   10                  15      


Ser Glu Asn Ser Ser Phe Tyr Tyr Tyr Asp Tyr Leu Asp Glu Val Ala 
            20                  25                  30          


Phe Met Leu Cys Arg Lys Asp Ala Val Val Ser Phe Gly Lys Val Phe 
        35                  40                  45              


Leu Pro Val Phe Tyr Ser Leu Ile Phe Val Leu Gly Leu Ser Gly Asn 
    50                  55                  60                  


Leu Leu Leu Leu Met Val Leu Leu Arg Tyr Val Pro Arg Arg Arg Met 
65                  70                  75                  80  


Val Glu Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asn Leu Leu Phe Leu 
                85                  90                  95      


Val Xaa Leu Pro Phe Trp Gly Ile Ser Val Ala Trp His Trp Val Phe 
            100                 105                 110         


Gly Ser Phe Leu Cys Lys Met Val Ser Xaa Leu Tyr Xaa Ile Asn Phe 
        115                 120                 125             


Tyr Ser Gly Ile Phe Phe Ile Ser Cys Met Ser Leu Asp Lys Tyr Leu 
    130                 135                 140                 


Glu Ile Val His Ala Gln Pro Tyr His Arg Leu Arg Xaa Arg Ala Lys 
145                 150                 155                 160 


Ser Leu Leu Leu Ala Xaa Ile Val Trp Ala 
                165                 170 


<210> 1357
<211> 233
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<400> 1357
Met Ala Ala Xaa Ala Ser Pro Gln Pro Leu Ala Xaa Glu Asp Ala Asp 
1               5                   10                  15      


Ser Glu Asn Ser Ser Phe Tyr Tyr Tyr Asp Tyr Leu Asp Glu Val Ala 
            20                  25                  30          


Phe Met Leu Cys Arg Lys Asp Ala Val Val Ser Phe Gly Lys Val Phe 
        35                  40                  45              


Leu Pro Val Phe Tyr Ser Leu Ile Phe Val Leu Gly Leu Ser Gly Asn 
    50                  55                  60                  


Leu Leu Leu Leu Met Val Leu Leu Arg Tyr Val Pro Arg Arg Arg Met 
65                  70                  75                  80  


Val Glu Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asn Leu Leu Phe Leu 
                85                  90                  95      


Val Xaa Leu Pro Phe Trp Gly Ile Ser Val Ala Trp His Trp Val Phe 
            100                 105                 110         


Gly Ser Phe Leu Cys Lys Met Val Ser Xaa Leu Tyr Xaa Ile Asn Phe 
        115                 120                 125             


Tyr Ser Gly Ile Phe Phe Ile Ser Cys Met Ser Leu Asp Lys Tyr Leu 
    130                 135                 140                 


Glu Ile Val His Ala Gln Pro Tyr His Arg Leu Arg Xaa Arg Ala Lys 
145                 150                 155                 160 


Ser Leu Leu Leu Ala Xaa Ile Val Trp Ala Val Ser Leu Ala Val Ser 
                165                 170                 175     


Ile Pro Asp Met Val Phe Val Gln Xaa His Glu Asn Pro Lys Gly Val 
            180                 185                 190         


Trp Asn Cys His Ala Asp Phe Gly Gly His Gly Xaa Ile Trp Lys Leu 
        195                 200                 205             


Phe Leu Arg Phe Gln Gln Asn Leu Leu Gly Phe Leu Leu Pro Leu Leu 
    210                 215                 220                 


Ala Met Ile Phe Phe Tyr Ser Arg Ile 
225                 230             


<210> 1358
<211> 384
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<400> 1358
Met Ala Ala Xaa Ala Ser Pro Gln Pro Leu Ala Xaa Glu Asp Ala Asp 
1               5                   10                  15      


Ser Glu Asn Ser Ser Phe Tyr Tyr Tyr Asp Tyr Leu Asp Glu Val Ala 
            20                  25                  30          


Phe Met Leu Cys Arg Lys Asp Ala Val Val Ser Phe Gly Lys Val Phe 
        35                  40                  45              


Leu Pro Val Phe Tyr Ser Leu Ile Phe Val Leu Gly Leu Ser Gly Asn 
    50                  55                  60                  


Leu Leu Leu Leu Met Val Leu Leu Arg Tyr Val Pro Arg Arg Arg Met 
65                  70                  75                  80  


Val Glu Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asn Leu Leu Phe Leu 
                85                  90                  95      


Val Xaa Leu Pro Phe Trp Gly Ile Ser Val Ala Trp His Trp Val Phe 
            100                 105                 110         


Gly Ser Phe Leu Cys Lys Met Val Ser Xaa Leu Tyr Xaa Ile Asn Phe 
        115                 120                 125             


Tyr Ser Gly Ile Phe Phe Ile Ser Cys Met Ser Leu Asp Lys Tyr Leu 
    130                 135                 140                 


Glu Ile Val His Ala Gln Pro Tyr His Arg Leu Arg Xaa Arg Ala Lys 
145                 150                 155                 160 


Ser Leu Leu Leu Ala Xaa Ile Val Trp Ala Val Ser Leu Ala Val Ser 
                165                 170                 175     


Ile Pro Asp Met Val Phe Val Gln Xaa His Glu Asn Pro Lys Gly Val 
            180                 185                 190         


Trp Asn Cys His Ala Asp Phe Gly Gly His Gly Xaa Ile Trp Lys Leu 
        195                 200                 205             


Phe Leu Arg Phe Gln Gln Asn Leu Leu Gly Phe Leu Leu Pro Leu Leu 
    210                 215                 220                 


Ala Met Ile Phe Phe Tyr Ser Arg Ile Gly Cys Val Leu Val Arg Leu 
225                 230                 235                 240 


Arg Pro Ala Gly Gln Gly Arg Ala Leu Lys Ile Ala Ala Ala Leu Val 
                245                 250                 255     


Val Ala Phe Phe Val Leu Trp Phe Pro Tyr Asn Leu Xaa Leu Phe Leu 
            260                 265                 270         


His Xaa Leu Leu Asp Leu Gln Val Phe Gly Asn Cys Glu Val Ser Gln 
        275                 280                 285             


His Leu Asp Tyr Ala Leu Gln Val Xaa Glu Ser Ile Ala Phe Leu His 
    290                 295                 300                 


Cys Cys Phe Ser Pro Ile Leu Tyr Ala Phe Ser Ser His Arg Phe Arg 
305                 310                 315                 320 


Gln Tyr Leu Lys Ala Phe Leu Ala Ala Val Leu Gly Trp His Leu Ala 
                325                 330                 335     


Pro Gly Xaa Ala Gln Ala Ser Leu Ser Ser Cys Ser Glu Ser Ser Ile 
            340                 345                 350         


Leu Xaa Ala Gln Glu Glu Met Xaa Gly Met Asn Asp Leu Gly Glu Arg 
        355                 360                 365             


Gln Ser Glu Asn Tyr Pro Asn Lys Glu Asp Val Gly Asn Lys Ser Ala 
    370                 375                 380                 


<210> 1359
<211> 211
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<400> 1359
Met Asp Leu His Leu Phe Asp Tyr Ser Glu Pro Gly Asn Phe Ser Asp 
1               5                   10                  15      


Ile Ser Trp Pro Cys Asn Ser Ser Asp Cys Ile Val Val Asp Xaa Val 
            20                  25                  30          


Met Cys Pro Asn Met Pro Asn Lys Ser Val Leu Leu Tyr Xaa Leu Ser 
        35                  40                  45              


Phe Ile Tyr Ile Phe Ile Phe Val Ile Gly Met Ile Ala Asn Ser Val 
    50                  55                  60                  


Val Val Trp Val Asn Ile Gln Ala Lys Xaa Xaa Gly Tyr Asp Xaa His 
65                  70                  75                  80  


Cys Tyr Ile Leu Asn Leu Ala Ile Ala Asp Leu Trp Val Val Leu Xaa 
                85                  90                  95      


Ile Pro Val Trp Val Val Ser Leu Val Gln His Asn Gln Trp Pro Met 
            100                 105                 110         


Gly Glu Leu Xaa Cys Lys Val Xaa His Leu Ile Phe Ser Ile Asn Leu 
        115                 120                 125             


Phe Gly Ser Ile Phe Phe Leu Xaa Cys Met Ser Val Asp Arg Tyr Leu 
    130                 135                 140                 


Ser Ile Xaa Tyr Phe Xaa Asn Xaa Pro Ser Ser Arg Lys Lys Met Val 
145                 150                 155                 160 


Arg Arg Val Val Cys Ile Leu Val Trp Leu Leu Ala Phe Cys Val Ser 
                165                 170                 175     


Leu Pro Asp Xaa Tyr Tyr Leu Lys Xaa Val Xaa Ser Ala Ser Asn Asn 
            180                 185                 190         


Glu Xaa Tyr Cys Arg Ser Phe Tyr Pro Glu His Ser Ile Lys Glu Trp 
        195                 200                 205             


Leu Ile Gly 
    210     


<210> 1360
<211> 362
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<400> 1360
Met Asp Leu His Leu Phe Asp Tyr Ser Glu Pro Gly Asn Phe Ser Asp 
1               5                   10                  15      


Ile Ser Trp Pro Cys Asn Ser Ser Asp Cys Ile Val Val Asp Xaa Val 
            20                  25                  30          


Met Cys Pro Asn Met Pro Asn Lys Ser Val Leu Leu Tyr Xaa Leu Ser 
        35                  40                  45              


Phe Ile Tyr Ile Phe Ile Phe Val Ile Gly Met Ile Ala Asn Ser Val 
    50                  55                  60                  


Val Val Trp Val Asn Ile Gln Ala Lys Xaa Xaa Gly Tyr Asp Xaa His 
65                  70                  75                  80  


Cys Tyr Ile Leu Asn Leu Ala Ile Ala Asp Leu Trp Val Val Leu Xaa 
                85                  90                  95      


Ile Pro Val Trp Val Val Ser Leu Val Gln His Asn Gln Trp Pro Met 
            100                 105                 110         


Gly Glu Leu Xaa Cys Lys Val Xaa His Leu Ile Phe Ser Ile Asn Leu 
        115                 120                 125             


Phe Gly Ser Ile Phe Phe Leu Xaa Cys Met Ser Val Asp Arg Tyr Leu 
    130                 135                 140                 


Ser Ile Xaa Tyr Phe Xaa Asn Xaa Pro Ser Ser Arg Lys Lys Met Val 
145                 150                 155                 160 


Arg Arg Val Val Cys Ile Leu Val Trp Leu Leu Ala Phe Cys Val Ser 
                165                 170                 175     


Leu Pro Asp Xaa Tyr Tyr Leu Lys Xaa Val Xaa Ser Ala Ser Asn Asn 
            180                 185                 190         


Glu Xaa Tyr Cys Arg Ser Phe Tyr Pro Glu His Ser Ile Lys Glu Trp 
        195                 200                 205             


Leu Ile Gly Met Glu Leu Val Ser Val Val Leu Gly Phe Ala Val Pro 
    210                 215                 220                 


Phe Ser Ile Ile Ala Val Phe Tyr Phe Leu Leu Ala Arg Ala Ile Ser 
225                 230                 235                 240 


Ala Ser Ser Asp Gln Glu Lys His Ser Ser Arg Lys Ile Ile Phe Ser 
                245                 250                 255     


Tyr Val Val Val Phe Leu Val Cys Trp Leu Pro Tyr His Val Ala Val 
            260                 265                 270         


Leu Leu Asp Ile Phe Ser Ile Leu His Tyr Ile Pro Phe Xaa Cys Arg 
        275                 280                 285             


Leu Glu His Ala Leu Phe Xaa Ala Leu His Val Xaa Gln Cys Leu Ser 
    290                 295                 300                 


Leu Val His Cys Cys Val Asn Pro Val Leu Tyr Ser Phe Ile Asn Arg 
305                 310                 315                 320 


Asn Tyr Arg Tyr Glu Leu Met Lys Ala Phe Ile Phe Lys Tyr Ser Ala 
                325                 330                 335     


Lys Xaa Gly Leu Xaa Lys Leu Ile Asp Ala Ser Arg Val Ser Glu Xaa 
            340                 345                 350         


Glu Tyr Ser Ala Leu Glu Gln Ser Xaa Lys 
        355                 360         


<210> 1361
<211> 350
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<400> 1361
Met Ala Leu Glu Gln Asn Gln Ser Xaa Asp Tyr Tyr Tyr Glu Glu Asn 
1               5                   10                  15      


Glu Met Asn Gly Xaa Tyr Asp Tyr Ser Gln Tyr Glu Leu Ile Cys Ile 
            20                  25                  30          


Lys Glu Asp Val Arg Glu Phe Ala Lys Val Phe Leu Pro Val Phe Leu 
        35                  40                  45              


Xaa Ile Val Phe Val Ile Gly Leu Ala Gly Asn Ser Met Val Val Ala 
    50                  55                  60                  


Ile Tyr Ala Tyr Tyr Lys Lys Gln Arg Xaa Lys Xaa Asp Val Tyr Ile 
65                  70                  75                  80  


Leu Asn Leu Ala Val Ala Asp Leu Leu Leu Leu Phe Xaa Leu Pro Phe 
                85                  90                  95      


Trp Ala Val Asn Ala Val His Gly Trp Val Leu Gly Lys Ile Met Cys 
            100                 105                 110         


Lys Ile Xaa Ser Ala Leu Tyr Xaa Leu Asn Phe Val Ser Gly Met Gln 
        115                 120                 125             


Phe Leu Ala Cys Ile Ser Ile Asp Arg Tyr Val Ala Val Xaa Lys Val 
    130                 135                 140                 


Pro Ser Gln Ser Gly Val Gly Lys Pro Cys Trp Ile Ile Cys Phe Cys 
145                 150                 155                 160 


Val Trp Met Ala Ala Ile Leu Leu Ser Ile Pro Gln Leu Val Phe Tyr 
                165                 170                 175     


Xaa Val Asn Asp Asn Ala Arg Cys Ile Pro Ile Phe Pro Arg Tyr Leu 
            180                 185                 190         


Gly Xaa Ser Met Lys Ala Leu Ile Gln Met Leu Glu Ile Cys Ile Gly 
        195                 200                 205             


Phe Val Val Pro Phe Leu Ile Met Gly Val Cys Tyr Phe Ile Xaa Ala 
    210                 215                 220                 


Arg Xaa Leu Met Lys Met Pro Asn Ile Lys Ile Ser Arg Pro Leu Lys 
225                 230                 235                 240 


Val Leu Leu Xaa Val Val Ile Val Phe Ile Val Xaa Gln Leu Pro Tyr 
                245                 250                 255     


Asn Ile Val Lys Phe Cys Arg Ala Ile Asp Ile Ile Tyr Ser Leu Ile 
            260                 265                 270         


Xaa Ser Cys Asn Met Ser Lys Arg Met Asp Ile Ala Ile Gln Val Xaa 
        275                 280                 285             


Glu Ser Ile Ala Leu Phe His Ser Cys Leu Asn Pro Ile Leu Tyr Val 
    290                 295                 300                 


Phe Met Gly Ala Ser Phe Lys Asn Tyr Val Met Lys Val Ala Lys Lys 
305                 310                 315                 320 


Tyr Gly Ser Trp Arg Arg Gln Arg Gln Ser Val Glu Glu Phe Pro Phe 
                325                 330                 335     


Asp Ser Glu Gly Pro Xaa Glu Pro Xaa Ser Xaa Phe Ser Ile 
            340                 345                 350 


<210> 1362
<211> 20
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<400> 1362
Val Glu Glu Phe Pro Phe Asp Ser Glu Gly Pro Xaa Glu Pro Xaa Ser 
1               5                   10                  15      


Xaa Phe Ser Ile 
            20  


<210> 1363
<211> 481
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<400> 1363
Phe Pro Leu Lys Ser Ile Xaa Glu Ser Phe Ala Xaa Ala Ile His Gly 
1               5                   10                  15      


Leu Lys Val Gly His Leu Xaa Asp Arg Val Ile Gln Arg Ser Lys Arg 
            20                  25                  30          


Met Ile Leu Asp Xaa Leu Gly Ala Gly Phe Leu Gly Xaa Xaa Xaa Glu 
        35                  40                  45              


Val Phe His Ile Ala Ser Gln Tyr Ser Lys Ile Tyr Ser Ser Asn Ile 
    50                  55                  60                  


Ser Ser Xaa Val Trp Gly Gln Pro Asp Ile Arg Leu Pro Pro Xaa Tyr 
65                  70                  75                  80  


Ala Ala Phe Val Asn Gly Val Ala Ile His Ser Met Asp Phe Asp Asp 
                85                  90                  95      


Xaa Trp His Pro Ala Xaa His Pro Ser Gly Ala Val Leu Pro Val Leu 
            100                 105                 110         


Xaa Ala Leu Ala Glu Ala Leu Pro Arg Ser Pro Lys Phe Ser Gly Leu 
        115                 120                 125             


Asp Leu Leu Leu Ala Phe Asn Val Gly Ile Glu Val Gln Gly Arg Leu 
    130                 135                 140                 


Leu His Phe Ala Lys Glu Ala Asn Asp Met Pro Lys Arg Phe His Pro 
145                 150                 155                 160 


Pro Ser Val Val Gly Xaa Leu Gly Ser Ala Ala Ala Ala Ser Lys Phe 
                165                 170                 175     


Leu Gly Leu Ser Ser Xaa Lys Cys Arg Glu Ala Leu Ala Ile Ala Val 
            180                 185                 190         


Ser His Ala Gly Ala Pro Met Ala Asn Ala Ala Xaa Gln Xaa Lys Pro 
        195                 200                 205             


Leu His Ile Gly Asn Ala Ala Lys His Gly Ile Glu Ala Ala Phe Leu 
    210                 215                 220                 


Ala Met Leu Gly Leu Gln Gly Asn Lys Gln Val Leu Asp Leu Glu Ala 
225                 230                 235                 240 


Gly Phe Gly Ala Phe Tyr Ala Asn Tyr Ser Pro Lys Val Leu Pro Ser 
                245                 250                 255     


Ile Ala Ser Tyr Ser Trp Leu Leu Asp Gln Gln Asp Val Ala Phe Lys 
            260                 265                 270         


Arg Phe Pro Ala His Leu Ser Xaa His Trp Val Ala Asp Ala Ala Ala 
        275                 280                 285             


Ser Val Arg Lys His Leu Val Ala Glu Arg Ala Leu Leu Pro Xaa Asp 
    290                 295                 300                 


Tyr Ile Lys Arg Ile Val Leu Arg Ile Pro Asn Val Gln Tyr Val Asn 
305                 310                 315                 320 


Arg Pro Phe Pro Val Ser Glu His Glu Ala Arg His Ser Phe Gln Tyr 
                325                 330                 335     


Val Ala Cys Ala Met Leu Leu Asp Gly Gly Ile Xaa Val Pro Ser Phe 
            340                 345                 350         


His Glu Cys Gln Ile Asn Arg Pro Gln Val Arg Glu Leu Leu Ser Lys 
        355                 360                 365             


Val Glu Leu Glu Tyr Pro Pro Asp Asn Leu Pro Ser Phe Asn Ile Leu 
    370                 375                 380                 


Tyr Cys Glu Ile Ser Val Xaa Leu Lys Asp Gly Ala Xaa Phe Xaa Asp 
385                 390                 395                 400 


Arg Ser Asp Xaa Phe Tyr Gly His Trp Arg Lys Pro Leu Ser Gln Glu 
                405                 410                 415     


Asp Leu Glu Glu Lys Phe Arg Ala Asn Ala Ser Lys Met Leu Ser Trp 
            420                 425                 430         


Asp Xaa Val Glu Ser Leu Ile Lys Ile Val Lys Asn Leu Glu Asp Leu 
        435                 440                 445             


Glu Asp Cys Ser Val Leu Xaa Xaa Leu Leu Lys Gly Pro Ser Pro Pro 
    450                 455                 460                 


Glu Val Ala Ser Asn Ser Pro Ala Cys Asn Asn Ser Ile Xaa Asn Leu 
465                 470                 475                 480 


Ser 
    


<210> 1364
<211> 481
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<400> 1364
Met Met Leu Lys Ser Ile Xaa Glu Ser Phe Ala Xaa Ala Ile His Gly 
1               5                   10                  15      


Leu Lys Val Gly His Leu Xaa Asp Arg Val Ile Gln Arg Ser Lys Arg 
            20                  25                  30          


Met Ile Leu Asp Xaa Leu Gly Ala Gly Phe Leu Gly Xaa Xaa Xaa Glu 
        35                  40                  45              


Val Phe His Ile Ala Ser Gln Tyr Ser Lys Ile Tyr Ser Ser Asn Ile 
    50                  55                  60                  


Ser Ser Xaa Val Trp Gly Gln Pro Asp Ile Arg Leu Pro Pro Xaa Tyr 
65                  70                  75                  80  


Ala Ala Phe Val Asn Gly Val Ala Ile His Ser Met Asp Phe Asp Asp 
                85                  90                  95      


Xaa Trp His Pro Ala Xaa His Pro Ser Gly Ala Val Leu Pro Val Leu 
            100                 105                 110         


Xaa Ala Leu Ala Glu Ala Leu Pro Arg Ser Pro Lys Phe Ser Gly Leu 
        115                 120                 125             


Asp Leu Leu Leu Ala Phe Asn Val Gly Ile Glu Val Gln Gly Arg Leu 
    130                 135                 140                 


Leu His Phe Ala Lys Glu Ala Asn Asp Met Pro Lys Arg Phe His Pro 
145                 150                 155                 160 


Pro Ser Val Val Gly Xaa Leu Gly Ser Ala Ala Ala Ala Ser Lys Phe 
                165                 170                 175     


Leu Gly Leu Ser Ser Xaa Lys Cys Arg Glu Ala Leu Ala Ile Ala Val 
            180                 185                 190         


Ser His Ala Gly Ala Pro Met Ala Asn Ala Ala Xaa Gln Xaa Lys Pro 
        195                 200                 205             


Leu His Ile Gly Asn Ala Ala Lys His Gly Ile Glu Ala Ala Phe Leu 
    210                 215                 220                 


Ala Met Leu Gly Leu Gln Gly Asn Lys Gln Val Leu Asp Leu Glu Ala 
225                 230                 235                 240 


Gly Phe Gly Ala Phe Tyr Ala Asn Tyr Ser Pro Lys Val Leu Pro Ser 
                245                 250                 255     


Ile Ala Ser Tyr Ser Trp Leu Leu Asp Gln Gln Asp Val Ala Phe Lys 
            260                 265                 270         


Arg Phe Pro Ala His Leu Ser Xaa His Trp Val Ala Asp Ala Ala Ala 
        275                 280                 285             


Ser Val Arg Lys His Leu Val Ala Glu Arg Ala Leu Leu Pro Xaa Asp 
    290                 295                 300                 


Tyr Ile Lys Arg Ile Val Leu Arg Ile Pro Asn Val Gln Tyr Val Asn 
305                 310                 315                 320 


Arg Pro Phe Pro Val Ser Glu His Glu Ala Arg His Ser Phe Gln Tyr 
                325                 330                 335     


Val Ala Cys Ala Met Leu Leu Asp Gly Gly Ile Xaa Val Pro Ser Phe 
            340                 345                 350         


His Glu Cys Gln Ile Asn Arg Pro Gln Val Arg Glu Leu Leu Ser Lys 
        355                 360                 365             


Val Glu Leu Glu Tyr Pro Pro Asp Asn Leu Pro Ser Phe Asn Ile Leu 
    370                 375                 380                 


Tyr Cys Glu Ile Ser Val Xaa Leu Lys Asp Gly Ala Xaa Phe Xaa Asp 
385                 390                 395                 400 


Arg Ser Asp Xaa Phe Tyr Gly His Trp Arg Lys Pro Leu Ser Gln Glu 
                405                 410                 415     


Asp Leu Glu Glu Lys Phe Arg Ala Asn Ala Ser Lys Met Leu Ser Trp 
            420                 425                 430         


Asp Xaa Val Glu Ser Leu Ile Lys Ile Val Lys Asn Leu Glu Asp Leu 
        435                 440                 445             


Glu Asp Cys Ser Val Leu Xaa Xaa Leu Leu Lys Gly Pro Ser Pro Pro 
    450                 455                 460                 


Glu Val Ala Ser Asn Ser Pro Ala Cys Asn Asn Ser Ile Xaa Asn Leu 
465                 470                 475                 480 


Ser 
    


<210> 1365
<211> 594
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<400> 1365
Met Ile Gln Asn Val Gly Asn His Leu Arg Arg Gly Leu Ala Ser Val 
1               5                   10                  15      


Phe Ser Asn Arg Xaa Ser Arg Lys Ser Ala Leu Arg Ala Gly Asn Asp 
            20                  25                  30          


Ser Ala Met Ala Asp Gly Glu Gly Tyr Arg Asn Pro Xaa Glu Val Gln 
        35                  40                  45              


Met Ser Gln Leu Val Leu Pro Cys His Xaa Asn Gln Arg Gly Glu Leu 
    50                  55                  60                  


Ser Val Gly Gln Leu Leu Lys Trp Ile Asp Xaa Xaa Ala Cys Leu Ser 
65                  70                  75                  80  


Ala Glu Arg His Ala Gly Cys Pro Cys Val Xaa Ala Ser Met Asp Asp 
                85                  90                  95      


Ile Tyr Phe Glu His Xaa Ile Ser Val Gly Gln Val Val Asn Ile Lys 
            100                 105                 110         


Ala Lys Val Asn Arg Ala Phe Asn Ser Ser Met Glu Val Gly Ile Gln 
        115                 120                 125             


Val Ala Ser Glu Asp Leu Cys Ser Glu Lys Gln Trp Asn Val Cys Lys 
    130                 135                 140                 


Ala Leu Ala Xaa Phe Val Ala Arg Arg Glu Ile Xaa Lys Val Lys Leu 
145                 150                 155                 160 


Lys Gln Ile Xaa Pro Arg Xaa Glu Glu Glu Lys Met Glu His Ser Val 
                165                 170                 175     


Ala Ala Glu Arg Arg Arg Met Arg Leu Val Tyr Ala Asp Xaa Ile Lys 
            180                 185                 190         


Asp Leu Leu Ala Asn Cys Ala Ile Gln Gly Asp Leu Glu Ser Arg Asp 
        195                 200                 205             


Cys Ser Arg Met Val Pro Ala Glu Lys Xaa Arg Val Glu Ser Val Glu 
    210                 215                 220                 


Leu Val Leu Pro Pro His Ala Asn His Gln Gly Asn Xaa Phe Gly Gly 
225                 230                 235                 240 


Gln Ile Met Ala Trp Met Glu Asn Val Ala Xaa Ile Ala Ala Ser Arg 
                245                 250                 255     


Leu Cys Arg Ala His Pro Xaa Leu Lys Ala Ile Glu Met Phe His Phe 
            260                 265                 270         


Arg Gly Pro Ser Gln Val Gly Asp Arg Leu Val Leu Lys Ala Ile Val 
        275                 280                 285             


Asn Asn Ala Phe Lys His Ser Met Glu Val Gly Val Cys Val Glu Ala 
    290                 295                 300                 


Tyr Arg Gln Glu Ala Glu Xaa His Arg Arg His Ile Asn Ser Ala Phe 
305                 310                 315                 320 


Met Xaa Phe Val Val Leu Asp Ala Asp Asp Gln Pro Gln Leu Leu Pro 
                325                 330                 335     


Trp Ile Arg Pro Gln Pro Gly Asp Gly Glu Arg Arg Tyr Arg Glu Ala 
            340                 345                 350         


Ser Ala Arg Lys Lys Ile Arg Leu Asp Arg Lys Tyr Ile Val Ser Cys 
        355                 360                 365             


Lys Gln Xaa Glu Val Pro Leu Ser Val Pro Trp Asp Pro Ser Asn Gln 
    370                 375                 380                 


Val Tyr Leu Ser Tyr Asn Asn Val Ser Ser Leu Lys Met Leu Val Ala 
385                 390                 395                 400 


Lys Asp Asn Trp Val Leu Ser Ser Glu Ile Ser Gln Val Arg Leu Tyr 
                405                 410                 415     


Xaa Leu Glu Asp Asp Lys Phe Leu Ser Phe His Met Glu Met Val Val 
            420                 425                 430         


His Val Asp Ala Ala Gln Ala Phe Leu Leu Leu Ser Asp Leu Arg Gln 
        435                 440                 445             


Arg Pro Glu Trp Asp Lys His Tyr Arg Ser Val Glu Leu Val Gln Gln 
    450                 455                 460                 


Val Asp Glu Asp Asp Ala Ile Tyr His Val Xaa Ser Pro Ala Leu Gly 
465                 470                 475                 480 


Gly His Xaa Lys Pro Gln Asp Phe Val Ile Leu Ala Ser Arg Arg Lys 
                485                 490                 495     


Pro Cys Asp Asn Gly Asp Pro Tyr Val Ile Ala Leu Arg Ser Val Xaa 
            500                 505                 510         


Leu Pro Xaa His Arg Glu Xaa Pro Glu Tyr Arg Arg Gly Glu Xaa Leu 
        515                 520                 525             


Cys Ser Gly Phe Cys Leu Trp Arg Glu Gly Asp Gln Leu Xaa Lys Val 
    530                 535                 540                 


Ser Tyr Tyr Asn Gln Ala Xaa Pro Gly Val Leu Asn Tyr Val Xaa Xaa 
545                 550                 555                 560 


Asn Val Ala Gly Leu Ser Ser Glu Phe Tyr Xaa Xaa Phe Lys Ala Cys 
                565                 570                 575     


Glu Gln Phe Leu Leu Asp Asn Arg Asn Asp Leu Ala Pro Ser Leu Gln 
            580                 585                 590         


Xaa Leu 
        


<210> 1366
<211> 607
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<400> 1366
Met Ile Gln Asn Val Gly Asn His Leu Arg Arg Gly Leu Ala Ser Val 
1               5                   10                  15      


Phe Ser Asn Arg Xaa Ser Arg Lys Ser Ala Leu Arg Ala Gly Asn Asp 
            20                  25                  30          


Ser Ala Met Ala Asp Gly Glu Gly Tyr Arg Asn Pro Xaa Glu Val Gln 
        35                  40                  45              


Met Ser Gln Leu Val Leu Pro Cys His Xaa Asn Gln Arg Gly Glu Leu 
    50                  55                  60                  


Ser Val Gly Gln Leu Leu Lys Trp Ile Asp Xaa Xaa Ala Cys Leu Ser 
65                  70                  75                  80  


Ala Glu Arg His Ala Gly Cys Pro Cys Val Xaa Ala Ser Met Asp Asp 
                85                  90                  95      


Ile Tyr Phe Glu His Xaa Ile Ser Val Gly Gln Val Val Asn Ile Lys 
            100                 105                 110         


Ala Lys Val Asn Arg Ala Phe Asn Ser Ser Met Glu Val Gly Ile Gln 
        115                 120                 125             


Val Ala Ser Glu Asp Leu Cys Ser Glu Lys Gln Trp Asn Val Cys Lys 
    130                 135                 140                 


Ala Leu Ala Xaa Phe Val Ala Arg Arg Glu Ile Xaa Lys Val Lys Leu 
145                 150                 155                 160 


Lys Gln Ile Xaa Pro Arg Xaa Glu Glu Glu Lys Met Glu His Ser Val 
                165                 170                 175     


Ala Ala Glu Arg Arg Arg Met Arg Leu Val Tyr Ala Asp Xaa Ile Lys 
            180                 185                 190         


Asp Leu Leu Ala Asn Cys Ala Ile Gln Gly Asp Leu Glu Ser Arg Asp 
        195                 200                 205             


Cys Ser Arg Met Val Pro Ala Glu Lys Xaa Arg Val Glu Ser Val Glu 
    210                 215                 220                 


Leu Val Leu Pro Pro His Ala Asn His Gln Gly Asn Xaa Phe Gly Gly 
225                 230                 235                 240 


Gln Ile Met Ala Trp Met Glu Asn Val Ala Xaa Ile Ala Ala Ser Arg 
                245                 250                 255     


Leu Cys Arg Ala His Pro Xaa Leu Lys Ala Ile Glu Met Phe His Phe 
            260                 265                 270         


Arg Gly Pro Ser Gln Val Gly Asp Arg Leu Val Leu Lys Ala Ile Val 
        275                 280                 285             


Asn Asn Ala Phe Lys His Ser Met Glu Val Gly Val Cys Val Glu Ala 
    290                 295                 300                 


Tyr Arg Gln Glu Ala Glu Xaa His Arg Arg His Ile Asn Ser Ala Phe 
305                 310                 315                 320 


Met Xaa Phe Val Val Leu Asp Ala Asp Asp Gln Pro Gln Leu Leu Pro 
                325                 330                 335     


Trp Ile Arg Pro Gln Pro Gly Asp Gly Glu Arg Arg Tyr Arg Glu Ala 
            340                 345                 350         


Ser Ala Arg Lys Lys Ile Arg Leu Asp Arg Lys Tyr Ile Val Ser Cys 
        355                 360                 365             


Lys Gln Xaa Glu Val Pro Leu Ser Val Pro Trp Asp Pro Ser Asn Gln 
    370                 375                 380                 


Val Tyr Leu Ser Tyr Asn Asn Val Ser Ser Leu Lys Met Leu Val Ala 
385                 390                 395                 400 


Lys Asp Asn Trp Val Leu Ser Ser Glu Ile Ser Gln Val Arg Leu Tyr 
                405                 410                 415     


Xaa Leu Glu Asp Asp Lys Phe Leu Ser Phe His Met Glu Met Val Val 
            420                 425                 430         


His Val Asp Ala Ala Gln Ala Phe Leu Leu Leu Ser Asp Leu Arg Gln 
        435                 440                 445             


Arg Pro Glu Trp Asp Lys His Tyr Arg Ser Val Glu Leu Val Gln Gln 
    450                 455                 460                 


Val Asp Glu Asp Asp Ala Ile Tyr His Val Xaa Ser Pro Ala Leu Gly 
465                 470                 475                 480 


Gly His Xaa Lys Pro Gln Asp Phe Val Ile Leu Ala Ser Arg Arg Lys 
                485                 490                 495     


Pro Cys Asp Asn Gly Asp Pro Tyr Val Ile Ala Leu Arg Ser Val Xaa 
            500                 505                 510         


Leu Pro Xaa His Arg Glu Xaa Pro Glu Tyr Arg Arg Gly Glu Xaa Leu 
        515                 520                 525             


Cys Ser Gly Phe Cys Leu Trp Arg Glu Gly Asp Gln Leu Xaa Lys Cys 
    530                 535                 540                 


Cys Trp Val Arg Val Ser Leu Xaa Glu Leu Val Ser Ala Ser Gly Phe 
545                 550                 555                 560 


Tyr Ser Trp Gly Leu Glu Ser Arg Ser Lys Gly Arg Arg Ser Asp Gly 
                565                 570                 575     


Trp Asn Gly Lys Leu Ala Gly Gly His Leu Ser Xaa Leu Lys Ala Ile 
            580                 585                 590         


Pro Val Ala Lys Ile Asn Ser Arg Phe Gly Tyr Leu Gln Asp Xaa 
        595                 600                 605         


<210> 1367
<211> 353
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<400> 1367
Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Xaa Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Xaa Phe Pro Xaa Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Xaa Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Xaa Asp Val Asp Arg Xaa 
            100                 105                 110         


Leu Met Ser Ala Met Xaa Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Xaa Val Pro Leu Ser Glu Asp Gln Asp Phe Ile Ala Xaa Leu Gly Lys 
145                 150                 155                 160 


Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys Val 
                165                 170                 175     


Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Xaa Leu Pro Ser 
            180                 185                 190         


Trp Ala Xaa Glu Asp Xaa Met Xaa Lys Leu Arg Glu Leu Ser Glu Leu 
        195                 200                 205             


Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser Arg 
    210                 215                 220                 


Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys Arg 
225                 230                 235                 240 


Ala Xaa Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala His 
                245                 250                 255     


Asp Xaa Xaa Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn Gly 
            260                 265                 270         


Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Xaa Glu Leu Tyr Phe Glu 
        275                 280                 285             


Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Xaa Gln His 
    290                 295                 300                 


Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro Leu 
305                 310                 315                 320 


Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp Ser 
                325                 330                 335     


Xaa Glu Cys Met Xaa Xaa Asn Ser His Gln Gly Xaa Glu Asp Ser Xaa 
            340                 345                 350         


Asp 
    


<210> 1368
<211> 386
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<400> 1368
Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Xaa Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Xaa Phe Pro Xaa Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Xaa Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Xaa Asp Val Asp Arg Xaa 
            100                 105                 110         


Leu Met Ser Ala Met Xaa Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Xaa Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
145                 150                 155                 160 


Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Xaa Leu Lys Ser Glu Glu 
                165                 170                 175     


Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Xaa Leu Gly 
            180                 185                 190         


Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
        195                 200                 205             


Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Xaa Leu Pro 
    210                 215                 220                 


Ser Trp Ala Xaa Glu Asp Xaa Met Xaa Lys Leu Arg Glu Leu Ser Glu 
225                 230                 235                 240 


Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                245                 250                 255     


Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
            260                 265                 270         


Arg Ala Xaa Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
        275                 280                 285             


His Asp Xaa Xaa Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
    290                 295                 300                 


Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Xaa Glu Leu Tyr Phe 
305                 310                 315                 320 


Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Xaa Gln 
                325                 330                 335     


His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
            340                 345                 350         


Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
        355                 360                 365             


Ser Xaa Glu Cys Met Xaa Xaa Asn Ser His Gln Gly Xaa Glu Asp Ser 
    370                 375                 380                 


Xaa Asp 
385     


<210> 1369
<211> 418
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(375)
<223> Selenocysteine

<400> 1369
Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Xaa Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Xaa Phe Pro Xaa Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Xaa Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Xaa Asp Val Asp Arg Xaa 
            100                 105                 110         


Leu Met Ser Ala Met Xaa Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Xaa Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
145                 150                 155                 160 


Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Xaa Leu Lys Ser Glu Glu 
                165                 170                 175     


Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Xaa Leu Gly 
            180                 185                 190         


Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
        195                 200                 205             


Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Xaa Leu Pro 
    210                 215                 220                 


Ser Trp Ala Xaa Glu Asp Xaa Met Xaa Lys Leu Arg Glu Leu Ser Glu 
225                 230                 235                 240 


Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                245                 250                 255     


Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
            260                 265                 270         


Arg Ala Xaa Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
        275                 280                 285             


His Asp Xaa Xaa Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
    290                 295                 300                 


Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Xaa Glu Leu Tyr Phe 
305                 310                 315                 320 


Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Xaa Gln 
                325                 330                 335     


His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
            340                 345                 350         


Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
        355                 360                 365             


Ser Xaa Glu Cys Met Xaa Xaa Asn Ser His Gln Val Leu Lys Val Ile 
    370                 375                 380                 


Phe Ala Val Ala Phe Cys Leu Ile Ser Ala Val Leu Met Val Leu Leu 
385                 390                 395                 400 


Phe Ile His Ile Arg Arg Gly Leu Cys Trp Gln Arg Glu Ser Tyr Gly 
                405                 410                 415     


Asn Ile 
        


<210> 1370
<211> 165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<400> 1370
Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Xaa Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Xaa Phe Pro Xaa Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Xaa Gln Val Tyr Ile Arg Ser Xaa Asp Val 
65                  70                  75                  80  


Asp Arg Xaa Leu Met Ser Ala Met Xaa Asn Leu Ala Ala Leu Phe Pro 
                85                  90                  95      


Pro Glu Gly Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile 
            100                 105                 110         


Pro Val His Xaa Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro 
        115                 120                 125             


Phe Arg Asn Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Xaa Leu Lys 
    130                 135                 140                 


Ser Glu Glu Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala 
145                 150                 155                 160 


Xaa Leu Gly Lys Leu 
                165 


<210> 1371
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 1371
Xaa Glu Leu Tyr Phe Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr 
1               5                   10                  15      


Arg Asn Glu Xaa Gln His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys 
            20                  25                  30          


Ser Pro Ser Cys Pro Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val 
        35                  40                  45              


Ile Pro Gln Asp Trp Ser Xaa Glu Cys Met Xaa Xaa Asn Ser His Gln 
    50                  55                  60                  


Gly Pro Ala Glu Xaa Ala His Ser Ala Arg Arg Asn His Asp Ile Ala 
65                  70                  75                  80  


Leu Pro Cys Gly Arg Ser Xaa Cys Leu Glu Asn Xaa Val Leu Tyr Tyr 
                85                  90                  95      


His Tyr Gly 
            


<210> 1372
<211> 294
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<400> 1372
Lys Arg Lys Glu Ala Glu Leu Arg Ser Gly Ile Ile Arg Asn Asn Ser 
1               5                   10                  15      


Leu Trp Asp Arg Leu Ile Phe His Lys Val Gln Ser Ser Leu Gly Gly 
            20                  25                  30          


Arg Val Arg Leu Met Val Xaa Gly Ala Ala Pro Val Ser Ala Xaa Val 
        35                  40                  45              


Leu Xaa Phe Leu Arg Ala Ala Leu Gly Cys Gln Phe Tyr Glu Gly Tyr 
    50                  55                  60                  


Gly Gln Xaa Glu Cys Xaa Ala Gly Cys Cys Leu Xaa Met Pro Gly Asp 
65                  70                  75                  80  


Trp Xaa Ala Gly His Val Gly Ala Pro Met Pro Cys Asn Leu Ile Lys 
                85                  90                  95      


Leu Val Asp Val Glu Glu Met Asn Tyr Met Ala Ala Glu Gly Glu Gly 
            100                 105                 110         


Glu Gly Tyr Leu Lys Asp Pro Ala Lys Xaa Ala Glu Ala Leu Asp Lys 
        115                 120                 125             


Asp Gly Trp Leu His Xaa Gly Asp Ile Gly Lys Trp Leu Pro Asn Gly 
    130                 135                 140                 


Xaa Leu Lys Ile Ile Asp Arg Lys Lys His Ile Phe Lys Leu Ala Gln 
145                 150                 155                 160 


Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu Asn Ile Tyr Met Arg Ser 
                165                 170                 175     


Glu Pro Val Ala Gln Val Phe Val His Gly Glu Ser Leu Gln Ala Phe 
            180                 185                 190         


Leu Ile Ala Ile Val Val Pro Asp Val Glu Xaa Leu Cys Ser Trp Ala 
        195                 200                 205             


Gln Lys Arg Gly Phe Glu Gly Ser Phe Glu Glu Leu Cys Arg Asn Lys 
    210                 215                 220                 


Asp Val Lys Lys Ala Ile Leu Glu Asp Met Val Arg Leu Gly Lys Asp 
225                 230                 235                 240 


Ser Gly Leu Lys Pro Phe Glu Gln Val Lys Gly Ile Xaa Leu His Pro 
                245                 250                 255     


Glu Leu Phe Ser Ile Asp Asn Gly Leu Leu Xaa Pro Xaa Met Lys Ala 
            260                 265                 270         


Lys Arg Pro Glu Leu Arg Asn Tyr Phe Arg Ser Gln Ile Asp Asp Leu 
        275                 280                 285             


Tyr Ser Xaa Ile Lys Val 
    290                 


<210> 1373
<211> 388
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<400> 1373
Met Gln Ala His Glu Leu Phe Arg Tyr Phe Arg Met Pro Glu Leu Val 
1               5                   10                  15      


Asp Phe Arg Gln Tyr Val Arg Xaa Leu Pro Xaa Asn Xaa Leu Met Gly 
            20                  25                  30          


Phe Gly Ala Phe Ala Ala Leu Xaa Xaa Phe Trp Tyr Ala Xaa Arg Pro 
        35                  40                  45              


Lys Pro Leu Lys Pro Pro Cys Asp Leu Ser Met Gln Ser Val Glu Val 
    50                  55                  60                  


Ala Gly Ser Gly Gly Ala Arg Arg Ser Ala Leu Leu Asp Ser Asp Glu 
65                  70                  75                  80  


Pro Leu Val Tyr Phe Tyr Asp Asp Val Xaa Xaa Leu Tyr Glu Gly Phe 
                85                  90                  95      


Gln Arg Gly Ile Gln Val Ser Asn Asn Gly Pro Cys Leu Gly Ser Arg 
            100                 105                 110         


Lys Pro Asp Gln Pro Tyr Glu Trp Leu Ser Tyr Lys Gln Val Ala Glu 
        115                 120                 125             


Leu Ser Glu Cys Ile Gly Ser Ala Leu Ile Gln Lys Gly Phe Lys Xaa 
    130                 135                 140                 


Ala Pro Asp Gln Phe Ile Gly Ile Phe Ala Gln Asn Arg Pro Glu Trp 
145                 150                 155                 160 


Val Ile Ile Glu Gln Gly Cys Phe Ala Tyr Ser Met Val Ile Val Pro 
                165                 170                 175     


Leu Tyr Asp Xaa Leu Gly Asn Glu Ala Ile Xaa Tyr Ile Val Asn Lys 
            180                 185                 190         


Ala Glu Leu Ser Leu Val Phe Val Asp Lys Pro Glu Lys Ala Lys Leu 
        195                 200                 205             


Leu Leu Glu Gly Val Glu Asn Lys Leu Ile Pro Gly Leu Lys Ile Ile 
    210                 215                 220                 


Val Val Met Asp Ala Tyr Gly Ser Glu Leu Val Glu Arg Gly Gln Arg 
225                 230                 235                 240 


Cys Gly Val Glu Val Xaa Ser Met Lys Ala Met Glu Asp Leu Gly Arg 
                245                 250                 255     


Ala Asn Arg Arg Lys Pro Lys Pro Pro Ala Pro Glu Asp Leu Ala Val 
            260                 265                 270         


Ile Cys Phe Xaa Ser Gly Xaa Xaa Gly Asn Pro Lys Gly Ala Met Val 
        275                 280                 285             


Xaa His Arg Asn Ile Val Ser Asp Cys Ser Ala Phe Val Lys Ala Xaa 
    290                 295                 300                 


Glu Asn Xaa Val Asn Pro Cys Pro Asp Asp Xaa Leu Ile Ser Phe Leu 
305                 310                 315                 320 


Pro Leu Ala His Met Phe Glu Arg Val Val Glu Cys Val Met Leu Cys 
                325                 330                 335     


His Gly Ala Lys Ile Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu Met 
            340                 345                 350         


Asp Asp Leu Lys Val Leu Gln Pro Xaa Val Phe Pro Val Val Pro Arg 
        355                 360                 365             


Leu Leu Asn Arg Met Phe Asp Arg Val Ser Ser Lys Gln Arg Ser Pro 
    370                 375                 380                 


Arg Xaa Glu His 
385             


<210> 1374
<211> 698
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<400> 1374
Met Gln Ala His Glu Leu Phe Arg Tyr Phe Arg Met Pro Glu Leu Val 
1               5                   10                  15      


Asp Phe Arg Gln Tyr Val Arg Xaa Leu Pro Xaa Asn Xaa Leu Met Gly 
            20                  25                  30          


Phe Gly Ala Phe Ala Ala Leu Xaa Xaa Phe Trp Tyr Ala Xaa Arg Pro 
        35                  40                  45              


Lys Pro Leu Lys Pro Pro Cys Asp Leu Ser Met Gln Ser Val Glu Val 
    50                  55                  60                  


Ala Gly Ser Gly Gly Ala Arg Arg Ser Ala Leu Leu Asp Ser Asp Glu 
65                  70                  75                  80  


Pro Leu Val Tyr Phe Tyr Asp Asp Val Xaa Xaa Leu Tyr Glu Gly Phe 
                85                  90                  95      


Gln Arg Gly Ile Gln Val Ser Asn Asn Gly Pro Cys Leu Gly Ser Arg 
            100                 105                 110         


Lys Pro Asp Gln Pro Tyr Glu Trp Leu Ser Tyr Lys Gln Val Ala Glu 
        115                 120                 125             


Leu Ser Glu Cys Ile Gly Ser Ala Leu Ile Gln Lys Gly Phe Lys Xaa 
    130                 135                 140                 


Ala Pro Asp Gln Phe Ile Gly Ile Phe Ala Gln Asn Arg Pro Glu Trp 
145                 150                 155                 160 


Val Ile Ile Glu Gln Gly Cys Phe Ala Tyr Ser Met Val Ile Val Pro 
                165                 170                 175     


Leu Tyr Asp Xaa Leu Gly Asn Glu Ala Ile Xaa Tyr Ile Val Asn Lys 
            180                 185                 190         


Ala Glu Leu Ser Leu Val Phe Val Asp Lys Pro Glu Lys Ala Lys Leu 
        195                 200                 205             


Leu Leu Glu Gly Val Glu Asn Lys Leu Ile Pro Gly Leu Lys Ile Ile 
    210                 215                 220                 


Val Val Met Asp Ala Tyr Gly Ser Glu Leu Val Glu Arg Gly Gln Arg 
225                 230                 235                 240 


Cys Gly Val Glu Val Xaa Ser Met Lys Ala Met Glu Asp Leu Gly Arg 
                245                 250                 255     


Ala Asn Arg Arg Lys Pro Lys Pro Pro Ala Pro Glu Asp Leu Ala Val 
            260                 265                 270         


Ile Cys Phe Xaa Ser Gly Xaa Xaa Gly Asn Pro Lys Gly Ala Met Val 
        275                 280                 285             


Xaa His Arg Asn Ile Val Ser Asp Cys Ser Ala Phe Val Lys Ala Xaa 
    290                 295                 300                 


Glu Asn Xaa Val Asn Pro Cys Pro Asp Asp Xaa Leu Ile Ser Phe Leu 
305                 310                 315                 320 


Pro Leu Ala His Met Phe Glu Arg Val Val Glu Cys Val Met Leu Cys 
                325                 330                 335     


His Gly Ala Lys Ile Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu Met 
            340                 345                 350         


Asp Asp Leu Lys Val Leu Gln Pro Xaa Val Phe Pro Val Val Pro Arg 
        355                 360                 365             


Leu Leu Asn Arg Met Phe Asp Arg Ile Phe Gly Gln Ala Asn Xaa Xaa 
    370                 375                 380                 


Leu Lys Arg Trp Leu Leu Asp Phe Ala Ser Lys Arg Lys Glu Ala Glu 
385                 390                 395                 400 


Leu Arg Ser Gly Ile Ile Arg Asn Asn Ser Leu Trp Asp Arg Leu Ile 
                405                 410                 415     


Phe His Lys Val Gln Ser Ser Leu Gly Gly Arg Val Arg Leu Met Val 
            420                 425                 430         


Xaa Gly Ala Ala Pro Val Ser Ala Xaa Val Leu Xaa Phe Leu Arg Ala 
        435                 440                 445             


Ala Leu Gly Cys Gln Phe Tyr Glu Gly Tyr Gly Gln Xaa Glu Cys Xaa 
    450                 455                 460                 


Ala Gly Cys Cys Leu Xaa Met Pro Gly Asp Trp Xaa Ala Gly His Val 
465                 470                 475                 480 


Gly Ala Pro Met Pro Cys Asn Leu Ile Lys Leu Val Asp Val Glu Glu 
                485                 490                 495     


Met Asn Tyr Met Ala Ala Glu Gly Glu Gly Glu Val Cys Val Lys Gly 
            500                 505                 510         


Pro Asn Val Phe Gln Gly Tyr Leu Lys Asp Pro Ala Lys Xaa Ala Glu 
        515                 520                 525             


Ala Leu Asp Lys Asp Gly Trp Leu His Xaa Gly Asp Ile Gly Lys Trp 
    530                 535                 540                 


Leu Pro Asn Gly Xaa Leu Lys Ile Ile Asp Arg Lys Lys His Ile Phe 
545                 550                 555                 560 


Lys Leu Ala Gln Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu Asn Ile 
                565                 570                 575     


Tyr Met Arg Ser Glu Pro Val Ala Gln Val Phe Val His Gly Glu Ser 
            580                 585                 590         


Leu Gln Ala Phe Leu Ile Ala Ile Val Val Pro Asp Val Glu Xaa Leu 
        595                 600                 605             


Cys Ser Trp Ala Gln Lys Arg Gly Phe Glu Gly Ser Phe Glu Glu Leu 
    610                 615                 620                 


Cys Arg Asn Lys Asp Val Lys Lys Ala Ile Leu Glu Asp Met Val Arg 
625                 630                 635                 640 


Leu Gly Lys Asp Ser Gly Leu Lys Pro Phe Glu Gln Val Lys Gly Ile 
                645                 650                 655     


Xaa Leu His Pro Glu Leu Phe Ser Ile Asp Asn Gly Leu Leu Xaa Pro 
            660                 665                 670         


Xaa Met Lys Ala Lys Arg Pro Glu Leu Arg Asn Tyr Phe Arg Ser Gln 
        675                 680                 685             


Ile Asp Asp Leu Tyr Ser Xaa Ile Lys Val 
    690                 695             


<210> 1375
<211> 698
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<400> 1375
Met Gln Ala His Glu Leu Phe Arg Tyr Phe Arg Met Pro Glu Leu Val 
1               5                   10                  15      


Asp Phe Arg Gln Tyr Val Arg Xaa Leu Pro Xaa Asn Xaa Leu Met Gly 
            20                  25                  30          


Phe Gly Ala Phe Ala Ala Leu Xaa Xaa Phe Trp Tyr Ala Xaa Arg Pro 
        35                  40                  45              


Lys Pro Leu Lys Pro Pro Cys Asp Leu Ser Met Gln Ser Val Glu Val 
    50                  55                  60                  


Ala Gly Ser Gly Gly Ala Arg Arg Ser Ala Leu Leu Asp Ser Asp Glu 
65                  70                  75                  80  


Pro Leu Val Tyr Phe Tyr Asp Asp Val Xaa Xaa Leu Tyr Glu Gly Phe 
                85                  90                  95      


Gln Arg Gly Ile Gln Val Ser Asn Asn Gly Pro Cys Leu Gly Ser Arg 
            100                 105                 110         


Lys Pro Asp Gln Pro Tyr Glu Trp Leu Ser Tyr Lys Gln Val Ala Glu 
        115                 120                 125             


Leu Ser Glu Cys Ile Gly Ser Ala Leu Ile Gln Lys Gly Phe Lys Xaa 
    130                 135                 140                 


Ala Pro Asp Gln Phe Ile Gly Ile Phe Ala Gln Asn Arg Pro Glu Trp 
145                 150                 155                 160 


Val Ile Ile Glu Gln Gly Cys Phe Ala Tyr Ser Met Val Ile Val Pro 
                165                 170                 175     


Leu Tyr Asp Xaa Leu Gly Asn Glu Ala Ile Xaa Tyr Ile Val Asn Lys 
            180                 185                 190         


Ala Glu Leu Ser Leu Val Phe Val Asp Lys Pro Glu Lys Ala Lys Leu 
        195                 200                 205             


Leu Leu Glu Gly Val Glu Asn Lys Leu Ile Pro Gly Leu Lys Ile Ile 
    210                 215                 220                 


Val Val Met Asp Ala Tyr Gly Ser Glu Leu Val Glu Arg Gly Gln Arg 
225                 230                 235                 240 


Cys Gly Val Glu Val Xaa Ser Met Lys Ala Met Glu Asp Leu Gly Arg 
                245                 250                 255     


Ala Asn Arg Arg Lys Pro Lys Pro Pro Ala Pro Glu Asp Leu Ala Val 
            260                 265                 270         


Ile Cys Phe Xaa Ser Gly Xaa Xaa Gly Asn Pro Lys Gly Ala Met Val 
        275                 280                 285             


Xaa His Arg Asn Ile Val Ser Asp Cys Ser Ala Phe Val Lys Ala Xaa 
    290                 295                 300                 


Glu Lys Ala Leu Pro Leu Ser Ala Ser Asp Xaa His Ile Ser Tyr Leu 
305                 310                 315                 320 


Pro Leu Ala His Ile Tyr Glu Gln Leu Leu Lys Cys Val Met Leu Cys 
                325                 330                 335     


His Gly Ala Lys Ile Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu Met 
            340                 345                 350         


Asp Asp Leu Lys Val Leu Gln Pro Xaa Val Phe Pro Val Val Pro Arg 
        355                 360                 365             


Leu Leu Asn Arg Met Phe Asp Arg Ile Phe Gly Gln Ala Asn Xaa Xaa 
    370                 375                 380                 


Leu Lys Arg Trp Leu Leu Asp Phe Ala Ser Lys Arg Lys Glu Ala Glu 
385                 390                 395                 400 


Leu Arg Ser Gly Ile Ile Arg Asn Asn Ser Leu Trp Asp Arg Leu Ile 
                405                 410                 415     


Phe His Lys Val Gln Ser Ser Leu Gly Gly Arg Val Arg Leu Met Val 
            420                 425                 430         


Xaa Gly Ala Ala Pro Val Ser Ala Xaa Val Leu Xaa Phe Leu Arg Ala 
        435                 440                 445             


Ala Leu Gly Cys Gln Phe Tyr Glu Gly Tyr Gly Gln Xaa Glu Cys Xaa 
    450                 455                 460                 


Ala Gly Cys Cys Leu Xaa Met Pro Gly Asp Trp Xaa Ala Gly His Val 
465                 470                 475                 480 


Gly Ala Pro Met Pro Cys Asn Leu Ile Lys Leu Val Asp Val Glu Glu 
                485                 490                 495     


Met Asn Tyr Met Ala Ala Glu Gly Glu Gly Glu Val Cys Val Lys Gly 
            500                 505                 510         


Pro Asn Val Phe Gln Gly Tyr Leu Lys Asp Pro Ala Lys Xaa Ala Glu 
        515                 520                 525             


Ala Leu Asp Lys Asp Gly Trp Leu His Xaa Gly Asp Ile Gly Lys Trp 
    530                 535                 540                 


Leu Pro Asn Gly Xaa Leu Lys Ile Ile Asp Arg Lys Lys His Ile Phe 
545                 550                 555                 560 


Lys Leu Ala Gln Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu Asn Ile 
                565                 570                 575     


Tyr Met Arg Ser Glu Pro Val Ala Gln Val Phe Val His Gly Glu Ser 
            580                 585                 590         


Leu Gln Ala Phe Leu Ile Ala Ile Val Val Pro Asp Val Glu Xaa Leu 
        595                 600                 605             


Cys Ser Trp Ala Gln Lys Arg Gly Phe Glu Gly Ser Phe Glu Glu Leu 
    610                 615                 620                 


Cys Arg Asn Lys Asp Val Lys Lys Ala Ile Leu Glu Asp Met Val Arg 
625                 630                 635                 640 


Leu Gly Lys Asp Ser Gly Leu Lys Pro Phe Glu Gln Val Lys Gly Ile 
                645                 650                 655     


Xaa Leu His Pro Glu Leu Phe Ser Ile Asp Asn Gly Leu Leu Xaa Pro 
            660                 665                 670         


Xaa Met Lys Ala Lys Arg Pro Glu Leu Arg Asn Tyr Phe Arg Ser Gln 
        675                 680                 685             


Ile Asp Asp Leu Tyr Ser Xaa Ile Lys Val 
    690                 695             


<210> 1376
<211> 664
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<400> 1376
Met Gln Ala His Glu Leu Phe Arg Tyr Phe Arg Met Pro Glu Leu Val 
1               5                   10                  15      


Asp Phe Arg Gln Tyr Val Arg Xaa Leu Pro Xaa Asn Xaa Leu Met Gly 
            20                  25                  30          


Phe Gly Ala Phe Ala Ala Leu Xaa Xaa Phe Trp Tyr Ala Xaa Arg Pro 
        35                  40                  45              


Lys Pro Leu Lys Pro Pro Cys Asp Leu Ser Met Gln Ser Val Glu Val 
    50                  55                  60                  


Ala Gly Ser Gly Gly Ala Arg Arg Ser Ala Leu Leu Asp Ser Asp Glu 
65                  70                  75                  80  


Pro Leu Val Tyr Phe Tyr Asp Asp Val Xaa Xaa Leu Tyr Glu Gly Phe 
                85                  90                  95      


Gln Arg Gly Ile Gln Val Ser Asn Asn Gly Pro Cys Leu Gly Ser Arg 
            100                 105                 110         


Lys Pro Asp Gln Pro Tyr Glu Trp Leu Ser Tyr Lys Gln Trp Val Ile 
        115                 120                 125             


Ile Glu Gln Gly Cys Phe Ala Tyr Ser Met Val Ile Val Pro Leu Tyr 
    130                 135                 140                 


Asp Xaa Leu Gly Asn Glu Ala Ile Xaa Tyr Ile Val Asn Lys Ala Glu 
145                 150                 155                 160 


Leu Ser Leu Val Phe Val Asp Lys Pro Glu Lys Ala Lys Leu Leu Leu 
                165                 170                 175     


Glu Gly Val Glu Asn Lys Leu Ile Pro Gly Leu Lys Ile Ile Val Val 
            180                 185                 190         


Met Asp Ala Tyr Gly Ser Glu Leu Val Glu Arg Gly Gln Arg Cys Gly 
        195                 200                 205             


Val Glu Val Xaa Ser Met Lys Ala Met Glu Asp Leu Gly Arg Ala Asn 
    210                 215                 220                 


Arg Arg Lys Pro Lys Pro Pro Ala Pro Glu Asp Leu Ala Val Ile Cys 
225                 230                 235                 240 


Phe Xaa Ser Gly Xaa Xaa Gly Asn Pro Lys Gly Ala Met Val Xaa His 
                245                 250                 255     


Arg Asn Ile Val Ser Asp Cys Ser Ala Phe Val Lys Ala Xaa Glu Asn 
            260                 265                 270         


Xaa Val Asn Pro Cys Pro Asp Asp Xaa Leu Ile Ser Phe Leu Pro Leu 
        275                 280                 285             


Ala His Met Phe Glu Arg Val Val Glu Cys Val Met Leu Cys His Gly 
    290                 295                 300                 


Ala Lys Ile Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu Met Asp Asp 
305                 310                 315                 320 


Leu Lys Val Leu Gln Pro Xaa Val Phe Pro Val Val Pro Arg Leu Leu 
                325                 330                 335     


Asn Arg Met Phe Asp Arg Ile Phe Gly Gln Ala Asn Xaa Xaa Leu Lys 
            340                 345                 350         


Arg Trp Leu Leu Asp Phe Ala Ser Lys Arg Lys Glu Ala Glu Leu Arg 
        355                 360                 365             


Ser Gly Ile Ile Arg Asn Asn Ser Leu Trp Asp Arg Leu Ile Phe His 
    370                 375                 380                 


Lys Val Gln Ser Ser Leu Gly Gly Arg Val Arg Leu Met Val Xaa Gly 
385                 390                 395                 400 


Ala Ala Pro Val Ser Ala Xaa Val Leu Xaa Phe Leu Arg Ala Ala Leu 
                405                 410                 415     


Gly Cys Gln Phe Tyr Glu Gly Tyr Gly Gln Xaa Glu Cys Xaa Ala Gly 
            420                 425                 430         


Cys Cys Leu Xaa Met Pro Gly Asp Trp Xaa Ala Gly His Val Gly Ala 
        435                 440                 445             


Pro Met Pro Cys Asn Leu Ile Lys Leu Val Asp Val Glu Glu Met Asn 
    450                 455                 460                 


Tyr Met Ala Ala Glu Gly Glu Gly Glu Val Cys Val Lys Gly Pro Asn 
465                 470                 475                 480 


Val Phe Gln Gly Tyr Leu Lys Asp Pro Ala Lys Xaa Ala Glu Ala Leu 
                485                 490                 495     


Asp Lys Asp Gly Trp Leu His Xaa Gly Asp Ile Gly Lys Trp Leu Pro 
            500                 505                 510         


Asn Gly Xaa Leu Lys Ile Ile Asp Arg Lys Lys His Ile Phe Lys Leu 
        515                 520                 525             


Ala Gln Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu Asn Ile Tyr Met 
    530                 535                 540                 


Arg Ser Glu Pro Val Ala Gln Val Phe Val His Gly Glu Ser Leu Gln 
545                 550                 555                 560 


Ala Phe Leu Ile Ala Ile Val Val Pro Asp Val Glu Xaa Leu Cys Ser 
                565                 570                 575     


Trp Ala Gln Lys Arg Gly Phe Glu Gly Ser Phe Glu Glu Leu Cys Arg 
            580                 585                 590         


Asn Lys Asp Val Lys Lys Ala Ile Leu Glu Asp Met Val Arg Leu Gly 
        595                 600                 605             


Lys Asp Ser Gly Leu Lys Pro Phe Glu Gln Val Lys Gly Ile Xaa Leu 
    610                 615                 620                 


His Pro Glu Leu Phe Ser Ile Asp Asn Gly Leu Leu Xaa Pro Xaa Met 
625                 630                 635                 640 


Lys Ala Lys Arg Pro Glu Leu Arg Asn Tyr Phe Arg Ser Gln Ile Asp 
                645                 650                 655     


Asp Leu Tyr Ser Xaa Ile Lys Val 
            660                 


<210> 1377
<211> 126
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<400> 1377
Met Gln Ala His Glu Leu Phe Arg Tyr Phe Arg Met Pro Glu Leu Val 
1               5                   10                  15      


Asp Phe Arg Gln Tyr Val Arg Xaa Leu Pro Xaa Asn Xaa Leu Met Gly 
            20                  25                  30          


Phe Gly Ala Phe Ala Ala Leu Xaa Xaa Phe Trp Tyr Ala Xaa Arg Pro 
        35                  40                  45              


Lys Pro Leu Lys Pro Pro Cys Asp Leu Ser Met Gln Ser Val Glu Val 
    50                  55                  60                  


Ala Gly Ser Gly Gly Ala Arg Arg Ser Ala Leu Leu Asp Ser Asp Glu 
65                  70                  75                  80  


Pro Leu Val Tyr Phe Tyr Asp Asp Val Xaa Xaa Leu Tyr Glu Gly Phe 
                85                  90                  95      


Gln Arg Gly Ile Gln Val Ser Arg Ser Leu Arg Pro Leu Cys Val His 
            100                 105                 110         


Cys Asn Phe Pro Arg Val Gly Pro Lys Ala His Trp Xaa Leu 
        115                 120                 125     


<210> 1378
<211> 527
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<400> 1378
Met Val Ile Val Pro Leu Tyr Asp Xaa Leu Gly Asn Glu Ala Ile Xaa 
1               5                   10                  15      


Tyr Ile Val Asn Lys Ala Glu Leu Ser Leu Val Phe Val Asp Lys Pro 
            20                  25                  30          


Glu Lys Ala Lys Leu Leu Leu Glu Gly Val Glu Asn Lys Leu Ile Pro 
        35                  40                  45              


Gly Leu Lys Ile Ile Val Val Met Asp Ala Tyr Gly Ser Glu Leu Val 
    50                  55                  60                  


Glu Arg Gly Gln Arg Cys Gly Val Glu Val Xaa Ser Met Lys Ala Met 
65                  70                  75                  80  


Glu Asp Leu Gly Arg Ala Asn Arg Arg Lys Pro Lys Pro Pro Ala Pro 
                85                  90                  95      


Glu Asp Leu Ala Val Ile Cys Phe Xaa Ser Gly Xaa Xaa Gly Asn Pro 
            100                 105                 110         


Lys Gly Ala Met Val Xaa His Arg Asn Ile Val Ser Asp Cys Ser Ala 
        115                 120                 125             


Phe Val Lys Ala Xaa Glu Asn Xaa Val Asn Pro Cys Pro Asp Asp Xaa 
    130                 135                 140                 


Leu Ile Ser Phe Leu Pro Leu Ala His Met Phe Glu Arg Val Val Glu 
145                 150                 155                 160 


Cys Val Met Leu Cys His Gly Ala Lys Ile Gly Phe Phe Gln Gly Asp 
                165                 170                 175     


Ile Arg Leu Leu Met Asp Asp Leu Lys Val Leu Gln Pro Xaa Val Phe 
            180                 185                 190         


Pro Val Val Pro Arg Leu Leu Asn Arg Met Phe Asp Arg Ile Phe Gly 
        195                 200                 205             


Gln Ala Asn Xaa Xaa Leu Lys Arg Trp Leu Leu Asp Phe Ala Ser Lys 
    210                 215                 220                 


Arg Lys Glu Ala Glu Leu Arg Ser Gly Ile Ile Arg Asn Asn Ser Leu 
225                 230                 235                 240 


Trp Asp Arg Leu Ile Phe His Lys Val Gln Ser Ser Leu Gly Gly Arg 
                245                 250                 255     


Val Arg Leu Met Val Xaa Gly Ala Ala Pro Val Ser Ala Xaa Val Leu 
            260                 265                 270         


Xaa Phe Leu Arg Ala Ala Leu Gly Cys Gln Phe Tyr Glu Gly Tyr Gly 
        275                 280                 285             


Gln Xaa Glu Cys Xaa Ala Gly Cys Cys Leu Xaa Met Pro Gly Asp Trp 
    290                 295                 300                 


Xaa Ala Gly His Val Gly Ala Pro Met Pro Cys Asn Leu Ile Lys Leu 
305                 310                 315                 320 


Val Asp Val Glu Glu Met Asn Tyr Met Ala Ala Glu Gly Glu Gly Glu 
                325                 330                 335     


Val Cys Val Lys Gly Pro Asn Val Phe Gln Gly Tyr Leu Lys Asp Pro 
            340                 345                 350         


Ala Lys Xaa Ala Glu Ala Leu Asp Lys Asp Gly Trp Leu His Xaa Gly 
        355                 360                 365             


Asp Ile Gly Lys Trp Leu Pro Asn Gly Xaa Leu Lys Ile Ile Asp Arg 
    370                 375                 380                 


Lys Lys His Ile Phe Lys Leu Ala Gln Gly Glu Tyr Ile Ala Pro Glu 
385                 390                 395                 400 


Lys Ile Glu Asn Ile Tyr Met Arg Ser Glu Pro Val Ala Gln Val Phe 
                405                 410                 415     


Val His Gly Glu Ser Leu Gln Ala Phe Leu Ile Ala Ile Val Val Pro 
            420                 425                 430         


Asp Val Glu Xaa Leu Cys Ser Trp Ala Gln Lys Arg Gly Phe Glu Gly 
        435                 440                 445             


Ser Phe Glu Glu Leu Cys Arg Asn Lys Asp Val Lys Lys Ala Ile Leu 
    450                 455                 460                 


Glu Asp Met Val Arg Leu Gly Lys Asp Ser Gly Leu Lys Pro Phe Glu 
465                 470                 475                 480 


Gln Val Lys Gly Ile Xaa Leu His Pro Glu Leu Phe Ser Ile Asp Asn 
                485                 490                 495     


Gly Leu Leu Xaa Pro Xaa Met Lys Ala Lys Arg Pro Glu Leu Arg Asn 
            500                 505                 510         


Tyr Phe Arg Ser Gln Ile Asp Asp Leu Tyr Ser Xaa Ile Lys Val 
        515                 520                 525         


<210> 1379
<211> 94
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<400> 1379
Xaa Leu Gly Arg Ala Asn Arg Arg Lys Pro Lys Pro Pro Ala Pro Glu 
1               5                   10                  15      


Asp Leu Ala Val Ile Cys Phe Xaa Ser Gly Xaa Xaa Gly Asn Pro Lys 
            20                  25                  30          


Gly Ala Met Val Xaa His Arg Asn Ile Val Ser Asp Cys Ser Ala Phe 
        35                  40                  45              


Val Lys Ala Xaa Glu Cys Val Met Leu Cys His Gly Ala Lys Ile Gly 
    50                  55                  60                  


Phe Phe Gln Gly Asp Ile Arg Leu Leu Met Asp Asp Leu Lys Val Leu 
65                  70                  75                  80  


Gln Pro Xaa Val Phe Pro Val Val Pro Arg Leu Leu Asn Arg 
                85                  90                  


<210> 1380
<211> 80
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<400> 1380
Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Xaa Leu Lys Tyr Pro Ile Glu His Gly Ile Val Xaa Asn Trp Asp 
65                  70                  75                  80  


<210> 1381
<211> 103
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 1381
Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Xaa Leu Lys Tyr Pro Ile Glu His Gly Ile Val Xaa Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Xaa Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val 
            100             


<210> 1382
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<400> 1382
Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Xaa Leu Lys Tyr Pro Ile Glu His Gly Ile Val Xaa Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Xaa Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Xaa Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Xaa Gln Asp Ser Leu Leu 
        115                 120                 125 


<210> 1383
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 1383
Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Xaa Leu Lys Tyr Pro Ile Glu His Gly Ile Val Xaa Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Xaa Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Xaa Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Xaa Gln Ile Met Phe Glu Xaa Phe Asn 
        115                 120                 125             


Xaa Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Xaa Xaa Gly Ile Val Met Asp Ser Gly Asp Gly Val Xaa 
145                 150                 155                 160 


His Xaa Val Pro 
                


<210> 1384
<211> 375
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<400> 1384
Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Xaa Leu Lys Tyr Pro Ile Glu His Gly Ile Val Xaa Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Xaa Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Xaa Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Xaa Gln Ile Met Phe Glu Xaa Phe Asn 
        115                 120                 125             


Xaa Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Xaa Xaa Gly Ile Val Met Asp Ser Gly Asp Gly Val Xaa 
145                 150                 155                 160 


His Xaa Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Xaa Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Xaa Glu Arg Gly Tyr Ser Phe Xaa Xaa Xaa Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Xaa Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Xaa Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Xaa Xaa Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Xaa Val Leu Ser Gly Gly Xaa Xaa 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Xaa Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Xaa Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Xaa Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210> 1385
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 1385
Met Leu Xaa Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly 
1               5                   10                  15      


Ser Gly Met Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala 
            20                  25                  30          


Val Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val 
        35                  40                  45              


Gly Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys 
    50                  55                  60                  


Arg Gly Ile Leu Xaa Leu Lys Tyr Pro Ile Glu His Gly Ile Val Xaa 
65                  70                  75                  80  


Asn Trp Asp Asp Met Glu Lys Ile Trp His His Xaa Phe Tyr Asn Glu 
                85                  90                  95      


Leu Arg Val 
            


<210> 1386
<211> 242
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<400> 1386
Met Glu Glu Glu Ile Ala Ala Leu Val Ile Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Asp Ser Tyr Val Gly Asp Glu 
        35                  40                  45              


Ala Gln Ser Lys Arg Gly Ile Leu Xaa Leu Lys Tyr Pro Ile Glu His 
    50                  55                  60                  


Gly Ile Val Xaa Asn Trp Asp Asp Met Glu Lys Ile Trp His His Xaa 
65                  70                  75                  80  


Phe Tyr Asn Glu Leu Arg Val Ala Pro Glu Glu His Pro Val Leu Leu 
                85                  90                  95      


Xaa Glu Ala Pro Leu Asn Pro Lys Ala Asn Arg Glu Lys Met Xaa Gln 
            100                 105                 110         


Ile Met Phe Glu Xaa Phe Asn Xaa Pro Ala Met Tyr Val Ala Ile Gln 
        115                 120                 125             


Ala Val Leu Ser Leu Tyr Ala Ser Gly Arg Xaa Xaa Gly Ile Val Met 
    130                 135                 140                 


Asp Ser Gly Asp Gly Val Xaa His Xaa Val Pro Ile Tyr Glu Gly Tyr 
145                 150                 155                 160 


Ala Leu Pro His Ala Ile Leu Arg Leu Asp Leu Ala Gly Arg Asp Leu 
                165                 170                 175     


Xaa Asp Tyr Leu Met Lys Ile Leu Xaa Glu Arg Gly Tyr Ser Phe Xaa 
            180                 185                 190         


Xaa Xaa Ala Glu Arg Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys 
        195                 200                 205             


Tyr Val Ala Leu Asp Phe Glu Gln Glu Met Ala Xaa Ala Ala Ser Ser 
    210                 215                 220                 


Ser Ser Leu Glu Lys Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Xaa 
225                 230                 235                 240 


Ile Gly 
        


<210> 1387
<211> 198
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<400> 1387
Met Glu Glu Glu Ile Ala Ala Leu Val Ile Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Xaa Leu Lys Tyr Pro Ile Glu His Gly Ile Val Xaa Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Xaa Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Xaa Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Xaa Gln Ala Leu Phe Leu Ser Arg His 
        115                 120                 125             


Phe Leu Pro Glu Ala Ser Arg Leu Cys Leu Arg Pro Ser Xaa Pro Arg 
    130                 135                 140                 


Pro Cys Xaa Trp Pro Ser Arg Pro Cys Cys Pro Ser Xaa Pro Leu Gly 
145                 150                 155                 160 


Ala Pro Leu Ala Leu Ser Trp Xaa Leu Glu Xaa Gly Ser Pro Xaa Arg 
                165                 170                 175     


Cys Pro Ser Xaa Arg Ala Xaa Pro Ser Pro Xaa Pro Ser Cys Val Trp 
            180                 185                 190         


Xaa Trp Leu Ala Gly Xaa 
        195             


<210> 1388
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 1388
Met Glu Glu Glu Ile Ala Ala Leu Val Ile Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Xaa Leu Lys Tyr Pro Ile Glu His Gly Ile Val Xaa Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Xaa Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Xaa Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Xaa Gln Ile Met Phe Glu Xaa Phe Asn 
        115                 120                 125             


Xaa Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Xaa Xaa Gly Ile Val Met Asp Ser Gly Asp Gly Val Xaa 
145                 150                 155                 160 


His Xaa Val Pro 
                


<210> 1389
<211> 214
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(203)
<223> Selenocysteine

<400> 1389
Met Glu Glu Glu Ile Ala Ala Leu Val Ile Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Xaa Leu Lys Tyr Pro Ile Glu His Gly Ile Val Xaa Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Xaa Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Xaa Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Xaa Gln Ile Met Phe Glu Xaa Phe Asn 
        115                 120                 125             


Xaa Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Xaa Xaa Gly Ile Val Met Asp Ser Gly Asp Gly Val Xaa 
145                 150                 155                 160 


His Xaa Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Xaa Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Xaa Glu Arg Gly Tyr Ser Phe Xaa Xaa Xaa Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu 
    210                 


<210> 1390
<211> 375
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<400> 1390
Met Glu Glu Glu Ile Ala Ala Leu Val Ile Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Xaa Leu Lys Tyr Pro Ile Glu His Gly Ile Val Xaa Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Xaa Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Xaa Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Xaa Gln Ile Met Phe Glu Xaa Phe Asn 
        115                 120                 125             


Xaa Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Xaa Xaa Gly Ile Val Met Asp Ser Gly Asp Gly Val Xaa 
145                 150                 155                 160 


His Xaa Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Xaa Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Xaa Glu Arg Gly Tyr Ser Phe Xaa Xaa Xaa Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Xaa Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Xaa Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Xaa Xaa Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Xaa Val Leu Ser Gly Gly Xaa Xaa 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Xaa Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Xaa Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Xaa Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210> 1391
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(125)
<223> Selenocysteine

<400> 1391
Met Glu Glu Glu Ile Ala Ala Leu Val Ile Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Xaa Leu Lys Tyr Pro Ile Glu His Gly Ile Val Xaa Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Xaa Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Xaa Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Val Leu Ser Leu Tyr Ala Ser Gly Arg Xaa Xaa Gly Ile Val 
        115                 120                 125             


Met Asp Ser Gly Asp 
    130             


<210> 1392
<211> 429
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<400> 1392
Met Ser Gly Gly Val Tyr Gly Gly Asp Glu Val Gly Ala Leu Val Phe 
1               5                   10                  15      


Asp Ile Gly Ser Tyr Xaa Val Arg Ala Gly Tyr Ala Gly Glu Asp Cys 
            20                  25                  30          


Pro Lys Val Asp Phe Pro Xaa Ala Ile Gly Met Val Val Glu Arg Asp 
        35                  40                  45              


Asp Gly Ser Xaa Leu Met Glu Ile Asp Gly Asp Lys Gly Lys Gln Gly 
    50                  55                  60                  


Gly Pro Xaa Tyr Tyr Ile Asp Xaa Asn Ala Leu Arg Val Pro Arg Glu 
65                  70                  75                  80  


Asn Met Glu Ala Ile Ser Pro Leu Lys Asn Gly Met Val Glu Asp Trp 
                85                  90                  95      


Asp Ser Phe Gln Ala Ile Leu Asp His Xaa Tyr Lys Met His Val Lys 
            100                 105                 110         


Ser Glu Ala Ser Leu His Pro Val Leu Met Ser Glu Ala Pro Trp Asn 
        115                 120                 125             


Xaa Arg Ala Lys Arg Glu Lys Leu Xaa Glu Leu Met Phe Glu His Tyr 
    130                 135                 140                 


Asn Ile Pro Ala Phe Phe Leu Cys Lys Xaa Ala Val Leu Xaa Ala Phe 
145                 150                 155                 160 


Ala Asn Gly Arg Ser Xaa Gly Leu Ile Leu Asp Ser Gly Ala Xaa His 
                165                 170                 175     


Xaa Xaa Ala Ile Pro Val His Asp Gly Tyr Val Leu Gln Gln Gly Ile 
            180                 185                 190         


Val Lys Ser Pro Leu Ala Gly Asp Phe Ile Xaa Met Gln Cys Arg Glu 
        195                 200                 205             


Leu Phe Gln Glu Met Asn Ile Glu Leu Val Pro Pro Tyr Met Ile Ala 
    210                 215                 220                 


Ser Lys Glu Ala Val Arg Glu Gly Ser Pro Ala Asn Trp Lys Arg Lys 
225                 230                 235                 240 


Glu Lys Leu Pro Gln Val Xaa Arg Ser Trp His Asn Tyr Met Cys Asn 
                245                 250                 255     


Cys Val Ile Gln Asp Phe Gln Ala Ser Val Leu Gln Val Ser Asp Ser 
            260                 265                 270         


Xaa Tyr Asp Glu Gln Val Ala Ala Gln Met Pro Xaa Val His Tyr Glu 
        275                 280                 285             


Phe Pro Asn Gly Tyr Asn Cys Asp Phe Gly Ala Glu Arg Leu Lys Ile 
    290                 295                 300                 


Pro Glu Gly Leu Phe Asp Pro Ser Asn Val Lys Gly Leu Ser Gly Asn 
305                 310                 315                 320 


Xaa Met Leu Gly Val Ser His Val Val Xaa Xaa Ser Val Gly Met Cys 
                325                 330                 335     


Asp Ile Asp Ile Arg Pro Gly Leu Tyr Gly Ser Val Ile Val Ala Gly 
            340                 345                 350         


Gly Asn Xaa Leu Ile Gln Ser Phe Xaa Asp Arg Leu Asn Arg Glu Leu 
        355                 360                 365             


Ser Gln Lys Xaa Pro Pro Ser Met Arg Leu Lys Leu Ile Ala Asn Asn 
    370                 375                 380                 


Xaa Xaa Val Glu Arg Arg Phe Ser Ser Trp Ile Gly Gly Ser Ile Leu 
385                 390                 395                 400 


Ala Ser Leu Gly Xaa Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr 
                405                 410                 415     


Glu Glu Gly Gly Lys Gln Cys Val Glu Arg Lys Cys Pro 
            420                 425                 


<210> 1393
<211> 50
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<400> 1393
Met Val Val Glu Arg Asp Asp Gly Ser Xaa Leu Met Glu Ile Asp Gly 
1               5                   10                  15      


Asp Lys Gly Lys Gln Gly Gly Pro Xaa Tyr Tyr Ile Asp Xaa Asn Ala 
            20                  25                  30          


Leu Arg Val Pro Arg Glu Asn Met Glu Ala Ile Ser Pro Leu Lys Asn 
        35                  40                  45              


Gly Met 
    50  


<210> 1394
<211> 387
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<400> 1394
Met Val Val Glu Arg Asp Asp Gly Ser Xaa Leu Met Glu Ile Asp Gly 
1               5                   10                  15      


Asp Lys Gly Lys Gln Gly Gly Pro Xaa Tyr Tyr Ile Asp Xaa Asn Ala 
            20                  25                  30          


Leu Arg Val Pro Arg Glu Asn Met Glu Ala Ile Ser Pro Leu Lys Asn 
        35                  40                  45              


Gly Met Val Glu Asp Trp Asp Ser Phe Gln Ala Ile Leu Asp His Xaa 
    50                  55                  60                  


Tyr Lys Met His Val Lys Ser Glu Ala Ser Leu His Pro Val Leu Met 
65                  70                  75                  80  


Ser Glu Ala Pro Trp Asn Xaa Arg Ala Lys Arg Glu Lys Leu Xaa Glu 
                85                  90                  95      


Leu Met Phe Glu His Tyr Asn Ile Pro Ala Phe Phe Leu Cys Lys Xaa 
            100                 105                 110         


Ala Val Leu Xaa Ala Phe Ala Asn Gly Arg Ser Xaa Gly Leu Ile Leu 
        115                 120                 125             


Asp Ser Gly Ala Xaa His Xaa Xaa Ala Ile Pro Val His Asp Gly Tyr 
    130                 135                 140                 


Val Leu Gln Gln Gly Ile Val Lys Ser Pro Leu Ala Gly Asp Phe Ile 
145                 150                 155                 160 


Xaa Met Gln Cys Arg Glu Leu Phe Gln Glu Met Asn Ile Glu Leu Val 
                165                 170                 175     


Pro Pro Tyr Met Ile Ala Ser Lys Glu Ala Val Arg Glu Gly Ser Pro 
            180                 185                 190         


Ala Asn Trp Lys Arg Lys Glu Lys Leu Pro Gln Val Xaa Arg Ser Trp 
        195                 200                 205             


His Asn Tyr Met Cys Asn Cys Val Ile Gln Asp Phe Gln Ala Ser Val 
    210                 215                 220                 


Leu Gln Val Ser Asp Ser Xaa Tyr Asp Glu Gln Val Ala Ala Gln Met 
225                 230                 235                 240 


Pro Xaa Val His Tyr Glu Phe Pro Asn Gly Tyr Asn Cys Asp Phe Gly 
                245                 250                 255     


Ala Glu Arg Leu Lys Ile Pro Glu Gly Leu Phe Asp Pro Ser Asn Val 
            260                 265                 270         


Lys Gly Leu Ser Gly Asn Xaa Met Leu Gly Val Ser His Val Val Xaa 
        275                 280                 285             


Xaa Ser Val Gly Met Cys Asp Ile Asp Ile Arg Pro Gly Leu Tyr Gly 
    290                 295                 300                 


Ser Val Ile Val Ala Gly Gly Asn Xaa Leu Ile Gln Ser Phe Xaa Asp 
305                 310                 315                 320 


Arg Leu Asn Arg Glu Leu Ser Gln Lys Xaa Pro Pro Ser Met Arg Leu 
                325                 330                 335     


Lys Leu Ile Ala Asn Asn Xaa Xaa Val Glu Arg Arg Phe Ser Ser Trp 
            340                 345                 350         


Ile Gly Gly Ser Ile Leu Ala Ser Leu Gly Xaa Phe Gln Gln Met Trp 
        355                 360                 365             


Ile Ser Lys Gln Glu Tyr Glu Glu Gly Gly Lys Gln Cys Val Glu Arg 
    370                 375                 380                 


Lys Cys Pro 
385         


<210> 1395
<211> 161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<400> 1395
Xaa Phe Ser Asp Glu Val Gly Ala Leu Val Phe Asp Ile Gly Ser Tyr 
1               5                   10                  15      


Xaa Val Arg Ala Gly Tyr Ala Gly Glu Asp Cys Pro Lys Val Asp Phe 
            20                  25                  30          


Pro Xaa Ala Ile Gly Met Val Val Glu Arg Asp Asp Gly Ser Xaa Leu 
        35                  40                  45              


Met Glu Ile Asp Gly Asp Lys Gly Lys Gln Gly Gly Pro Xaa Tyr Tyr 
    50                  55                  60                  


Ile Asp Xaa Asn Ala Leu Arg Val Pro Arg Glu Asn Met Glu Ala Ile 
65                  70                  75                  80  


Ser Pro Leu Lys Asn Gly Met Val Glu Asp Trp Asp Ser Phe Gln Ala 
                85                  90                  95      


Ile Leu Asp His Xaa Tyr Lys Met His Val Lys Ser Glu Ala Ser Leu 
            100                 105                 110         


His Pro Val Leu Met Ser Glu Ala Pro Trp Asn Xaa Arg Ala Lys Arg 
        115                 120                 125             


Glu Lys Leu Xaa Glu Leu Met Phe Glu His Tyr Asn Ile Pro Ala Phe 
    130                 135                 140                 


Phe Leu Cys Lys Xaa Ala Val Leu Xaa Ala Phe Ile His His Leu Leu 
145                 150                 155                 160 


His 
    


<210> 1396
<211> 426
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<400> 1396
Met Ser Gly Gly Val Tyr Gly Gly Asp Glu Val Gly Ala Leu Val Phe 
1               5                   10                  15      


Asp Ile Gly Ser Phe Ser Val Arg Ala Gly Tyr Ala Gly Glu Asp Cys 
            20                  25                  30          


Pro Lys Ala Asp Phe Pro Xaa Xaa Val Gly Leu Leu Ala Ala Glu Glu 
        35                  40                  45              


Gly Gly Gly Leu Glu Leu Glu Gly Asp Lys Glu Lys Lys Gly Lys Ile 
    50                  55                  60                  


Phe His Ile Asp Xaa Asn Ala Leu His Val Pro Arg Asp Gly Ala Glu 
65                  70                  75                  80  


Val Met Ser Pro Leu Lys Asn Gly Met Ile Glu Asp Trp Glu Cys Phe 
                85                  90                  95      


Arg Ala Ile Leu Asp His Xaa Tyr Ser Lys His Val Lys Ser Glu Pro 
            100                 105                 110         


Asn Leu His Pro Val Leu Met Ser Glu Ala Pro Trp Asn Xaa Arg Ala 
        115                 120                 125             


Lys Arg Glu Lys Leu Xaa Glu Leu Met Phe Glu Gln Tyr Asn Ile Pro 
    130                 135                 140                 


Ala Phe Phe Leu Cys Lys Xaa Ala Val Leu Xaa Ala Phe Ala Asn Gly 
145                 150                 155                 160 


Arg Ser Xaa Gly Leu Val Leu Asp Ser Gly Ala Xaa His Xaa Xaa Ala 
                165                 170                 175     


Ile Pro Val His Asp Gly Tyr Val Leu Gln Gln Gly Ile Val Lys Ser 
            180                 185                 190         


Pro Leu Ala Gly Asp Phe Ile Ser Met Gln Cys Arg Glu Leu Phe Gln 
        195                 200                 205             


Glu Met Ala Ile Asp Ile Ile Pro Pro Tyr Met Ile Ala Ala Lys Glu 
    210                 215                 220                 


Pro Val Arg Glu Gly Ala Pro Pro Asn Trp Lys Lys Lys Glu Lys Leu 
225                 230                 235                 240 


Pro Gln Val Ser Lys Ser Trp His Asn Tyr Met Cys Asn Glu Val Ile 
                245                 250                 255     


Gln Asp Phe Gln Ala Ser Val Leu Gln Val Ser Asp Ser Pro Tyr Asp 
            260                 265                 270         


Glu Gln Val Ala Ala Gln Met Pro Xaa Val His Tyr Glu Met Pro Asn 
        275                 280                 285             


Gly Tyr Asn Xaa Asp Tyr Gly Ala Glu Arg Leu Arg Ile Pro Glu Gly 
    290                 295                 300                 


Leu Phe Asp Pro Ser Asn Val Lys Gly Leu Ser Gly Asn Xaa Met Leu 
305                 310                 315                 320 


Gly Val Gly His Val Val Xaa Xaa Ser Ile Gly Met Cys Asp Ile Asp 
                325                 330                 335     


Ile Arg Pro Gly Leu Tyr Gly Ser Val Ile Val Xaa Gly Gly Asn Xaa 
            340                 345                 350         


Leu Leu Gln Gly Phe Xaa Asp Arg Leu Asn Arg Glu Leu Ser Gln Lys 
        355                 360                 365             


Xaa Pro Pro Ser Met Arg Leu Lys Leu Ile Ala Ser Asn Ser Xaa Met 
    370                 375                 380                 


Glu Arg Lys Phe Ser Pro Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu 
385                 390                 395                 400 


Gly Xaa Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Glu Glu Gly 
                405                 410                 415     


Gly Lys Gln Cys Val Glu Arg Lys Cys Pro 
            420                 425     


<210> 1397
<211> 66
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 1397
Met Ser Pro Leu Lys Asn Gly Met Ile Glu Asp Trp Glu Cys Phe Arg 
1               5                   10                  15      


Ala Ile Leu Asp His Xaa Tyr Ser Lys His Val Lys Ser Glu Pro Asn 
            20                  25                  30          


Leu His Pro Val Leu Met Ser Glu Ala Pro Trp Asn Xaa Arg Ala Lys 
        35                  40                  45              


Arg Glu Lys Leu Xaa Glu Leu Met Phe Glu Gln Tyr Asn Ile Pro Ala 
    50                  55                  60                  


Phe Phe 
65      


<210> 1398
<211> 894
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<400> 1398
Met Asn Gln Ile Glu Pro Gly Val Gln Tyr Asn Tyr Val Tyr Asp Glu 
1               5                   10                  15      


Asp Glu Tyr Met Ile Gln Glu Glu Glu Trp Asp Arg Asp Leu Leu Leu 
            20                  25                  30          


Asp Pro Ala Trp Glu Lys Gln Gln Arg Lys Xaa Phe Xaa Ala Trp Cys 
        35                  40                  45              


Asn Ser His Leu Arg Lys Ala Gly Xaa Gln Ile Glu Asn Ile Glu Glu 
    50                  55                  60                  


Asp Phe Arg Asn Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser 
65                  70                  75                  80  


Gly Glu Arg Leu Pro Lys Pro Asp Arg Gly Lys Met Arg Phe His Lys 
                85                  90                  95      


Ile Ala Asn Val Asn Lys Ala Leu Asp Tyr Ile Ala Ser Lys Gly Val 
            100                 105                 110         


Lys Leu Val Ser Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Val Lys 
        115                 120                 125             


Met Xaa Leu Gly Met Ile Trp Xaa Ile Ile Leu Arg Phe Ala Ile Gln 
    130                 135                 140                 


Asp Ile Ser Val Glu Glu Xaa Ser Ala Lys Glu Gly Leu Leu Leu Trp 
145                 150                 155                 160 


Cys Gln Arg Lys Xaa Ala Pro Tyr Arg Asn Val Asn Ile Gln Asn Phe 
                165                 170                 175     


His Xaa Ser Trp Lys Asp Gly Leu Gly Leu Cys Ala Leu Ile His Arg 
            180                 185                 190         


His Arg Pro Asp Leu Ile Asp Tyr Ser Lys Leu Asn Lys Asp Asp Pro 
        195                 200                 205             


Ile Gly Asn Ile Asn Leu Ala Met Glu Ile Ala Glu Lys His Leu Asp 
    210                 215                 220                 


Ile Pro Lys Met Leu Asp Ala Glu Asp Ile Val Asn Xaa Pro Lys Pro 
225                 230                 235                 240 


Asp Glu Arg Ala Ile Met Xaa Tyr Val Ser Cys Phe Tyr His Ala Phe 
                245                 250                 255     


Ala Gly Ala Glu Gln Ala Glu Xaa Ala Ala Asn Arg Ile Cys Lys Val 
            260                 265                 270         


Leu Ala Val Asn Gln Glu Asn Glu Arg Leu Met Glu Glu Tyr Glu Arg 
        275                 280                 285             


Leu Ala Ser Glu Leu Leu Glu Trp Ile Arg Arg Xaa Ile Pro Trp Leu 
    290                 295                 300                 


Glu Asn Arg Xaa Pro Glu Lys Xaa Met Gln Ala Met Gln Lys Lys Leu 
305                 310                 315                 320 


Glu Asp Phe Arg Asp Tyr Arg Arg Lys His Lys Pro Pro Lys Val Gln 
                325                 330                 335     


Glu Lys Cys Gln Leu Glu Ile Asn Phe Asn Xaa Leu Gln Xaa Lys Leu 
            340                 345                 350         


Arg Ile Ser Asn Arg Pro Ala Phe Met Pro Ser Glu Gly Lys Met Val 
        355                 360                 365             


Ser Asp Ile Ala Gly Ala Trp Gln Arg Leu Glu Gln Ala Glu Lys Gly 
    370                 375                 380                 


Tyr Glu Glu Trp Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu Glu 
385                 390                 395                 400 


His Leu Ala Glu Lys Phe Arg Gln Lys Ala Ser Xaa His Glu Xaa Trp 
                405                 410                 415     


Ala Tyr Gly Lys Glu Gln Ile Leu Leu Gln Lys Asp Tyr Glu Ser Ala 
            420                 425                 430         


Ser Leu Xaa Glu Val Arg Ala Leu Leu Arg Lys His Glu Ala Phe Glu 
        435                 440                 445             


Ser Asp Leu Ala Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile 
    450                 455                 460                 


Ala Gln Glu Leu Asn Glu Leu Asp Tyr His Asp Ala Val Asn Val Asn 
465                 470                 475                 480 


Asp Arg Cys Gln Lys Ile Cys Asp Gln Trp Asp Arg Leu Gly Xaa Leu 
                485                 490                 495     


Xaa Gln Lys Arg Arg Glu Ala Leu Glu Arg Met Glu Lys Leu Leu Glu 
            500                 505                 510         


Xaa Ile Asp Gln Leu His Leu Glu Phe Ala Lys Arg Ala Ala Pro Phe 
        515                 520                 525             


Asn Asn Trp Met Glu Gly Ala Met Glu Asp Leu Gln Asp Met Phe Ile 
    530                 535                 540                 


Val His Ser Ile Glu Glu Ile Gln Ser Leu Ile Xaa Ala His Glu Gln 
545                 550                 555                 560 


Phe Lys Ala Xaa Leu Pro Glu Ala Asp Gly Glu Arg Gln Ser Ile Met 
                565                 570                 575     


Ala Ile Gln Asn Glu Val Glu Lys Val Ile Gln Ser Tyr Asn Ile Arg 
            580                 585                 590         


Ile Ser Ser Ser Asn Pro Tyr Ser Xaa Val Xaa Met Asp Glu Leu Arg 
        595                 600                 605             


Xaa Lys Trp Asp Lys Val Lys Gln Leu Val Pro Ile Arg Asp Gln Ser 
    610                 615                 620                 


Leu Gln Glu Glu Leu Ala Arg Gln His Ala Asn Glu Arg Leu Arg Arg 
625                 630                 635                 640 


Gln Phe Ala Ala Gln Ala Asn Ala Ile Gly Pro Trp Ile Gln Asn Lys 
                645                 650                 655     


Met Glu Glu Ile Ala Arg Ser Ser Ile Gln Ile Xaa Gly Ala Leu Glu 
            660                 665                 670         


Asp Gln Met Asn Gln Leu Lys Gln Tyr Glu His Asn Ile Ile Asn Tyr 
        675                 680                 685             


Lys Asn Asn Ile Asp Lys Leu Glu Gly Asp His Gln Leu Ile Gln Glu 
    690                 695                 700                 


Ala Leu Val Phe Asp Asn Lys His Xaa Asn Tyr Xaa Met Glu His Ile 
705                 710                 715                 720 


Arg Val Gly Trp Glu Leu Leu Leu Xaa Xaa Ile Ala Arg Xaa Ile Asn 
                725                 730                 735     


Glu Val Glu Xaa Gln Ile Leu Xaa Arg Asp Ala Lys Gly Ile Xaa Gln 
            740                 745                 750         


Glu Gln Met Asn Glu Phe Arg Ala Ser Phe Asn His Phe Asp Arg Arg 
        755                 760                 765             


Lys Asn Gly Leu Met Asp His Glu Asp Phe Arg Ala Cys Leu Ile Ser 
    770                 775                 780                 


Met Gly Tyr Asp Leu Gly Glu Ala Glu Phe Ala Arg Ile Met Xaa Leu 
785                 790                 795                 800 


Val Asp Pro Asn Gly Gln Gly Xaa Val Xaa Phe Gln Ser Phe Ile Asp 
                805                 810                 815     


Phe Met Xaa Arg Glu Xaa Ala Asp Xaa Asp Xaa Ala Glu Gln Val Ile 
            820                 825                 830         


Ala Ser Phe Arg Ile Leu Ala Ser Asp Lys Pro Tyr Ile Leu Ala Glu 
        835                 840                 845             


Glu Leu Arg Arg Glu Leu Pro Pro Asp Gln Ala Gln Tyr Cys Ile Lys 
    850                 855                 860                 


Arg Met Pro Ala Tyr Ser Gly Pro Gly Ser Val Pro Gly Ala Leu Asp 
865                 870                 875                 880 


Tyr Ala Ala Phe Ser Ser Ala Leu Tyr Gly Glu Ser Asp Leu 
                885                 890                 


<210> 1399
<211> 894
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<400> 1399
Met Asn Gln Ile Glu Pro Gly Val Gln Tyr Asn Tyr Val Tyr Asp Glu 
1               5                   10                  15      


Asp Glu Tyr Met Ile Gln Glu Glu Glu Trp Asp Arg Asp Leu Leu Leu 
            20                  25                  30          


Asp Pro Ala Trp Glu Lys Gln Gln Arg Lys Xaa Phe Xaa Ala Trp Cys 
        35                  40                  45              


Asn Ser His Leu Arg Lys Ala Gly Xaa Gln Ile Glu Asn Ile Glu Glu 
    50                  55                  60                  


Asp Phe Arg Asn Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser 
65                  70                  75                  80  


Gly Glu Arg Leu Pro Lys Pro Asp Arg Gly Lys Met Arg Phe His Lys 
                85                  90                  95      


Ile Ala Asn Val Asn Lys Ala Leu Asp Tyr Ile Ala Ser Lys Gly Val 
            100                 105                 110         


Lys Leu Val Ser Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Val Lys 
        115                 120                 125             


Met Xaa Leu Gly Met Ile Trp Xaa Ile Ile Leu Arg Phe Ala Ile Gln 
    130                 135                 140                 


Asp Ile Ser Val Glu Glu Xaa Ser Ala Lys Glu Gly Leu Leu Leu Trp 
145                 150                 155                 160 


Cys Gln Arg Lys Xaa Ala Pro Tyr Arg Asn Val Asn Ile Gln Asn Phe 
                165                 170                 175     


His Xaa Ser Trp Lys Asp Gly Leu Gly Leu Cys Ala Leu Ile His Arg 
            180                 185                 190         


His Arg Pro Asp Leu Ile Asp Tyr Ser Lys Leu Asn Lys Asp Asp Pro 
        195                 200                 205             


Ile Gly Asn Ile Asn Leu Ala Met Glu Ile Ala Glu Lys His Leu Asp 
    210                 215                 220                 


Ile Pro Lys Met Leu Asp Ala Glu Asp Leu Val Tyr Xaa Ala Arg Pro 
225                 230                 235                 240 


Asp Glu Arg Ala Ile Met Xaa Tyr Val Ser Cys Tyr Tyr His Ala Phe 
                245                 250                 255     


Ala Gly Ala Gln Lys Ala Glu Xaa Ala Ala Asn Arg Ile Cys Lys Val 
            260                 265                 270         


Leu Ala Val Asn Gln Glu Asn Glu Arg Leu Met Glu Glu Tyr Glu Arg 
        275                 280                 285             


Leu Ala Ser Glu Leu Leu Glu Trp Ile Arg Arg Xaa Ile Pro Trp Leu 
    290                 295                 300                 


Glu Asn Arg Xaa Pro Glu Lys Xaa Met Gln Ala Met Gln Lys Lys Leu 
305                 310                 315                 320 


Glu Asp Phe Arg Asp Tyr Arg Arg Lys His Lys Pro Pro Lys Val Gln 
                325                 330                 335     


Glu Lys Cys Gln Leu Glu Ile Asn Phe Asn Xaa Leu Gln Xaa Lys Leu 
            340                 345                 350         


Arg Ile Ser Asn Arg Pro Ala Phe Met Pro Ser Glu Gly Lys Met Val 
        355                 360                 365             


Ser Asp Ile Ala Gly Ala Trp Gln Arg Leu Glu Gln Ala Glu Lys Gly 
    370                 375                 380                 


Tyr Glu Glu Trp Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu Glu 
385                 390                 395                 400 


His Leu Ala Glu Lys Phe Arg Gln Lys Ala Ser Xaa His Glu Xaa Trp 
                405                 410                 415     


Ala Tyr Gly Lys Glu Gln Ile Leu Leu Gln Lys Asp Tyr Glu Ser Ala 
            420                 425                 430         


Ser Leu Xaa Glu Val Arg Ala Leu Leu Arg Lys His Glu Ala Phe Glu 
        435                 440                 445             


Ser Asp Leu Ala Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile 
    450                 455                 460                 


Ala Gln Glu Leu Asn Glu Leu Asp Tyr His Asp Ala Val Asn Val Asn 
465                 470                 475                 480 


Asp Arg Cys Gln Lys Ile Cys Asp Gln Trp Asp Arg Leu Gly Xaa Leu 
                485                 490                 495     


Xaa Gln Lys Arg Arg Glu Ala Leu Glu Arg Met Glu Lys Leu Leu Glu 
            500                 505                 510         


Xaa Ile Asp Gln Leu His Leu Glu Phe Ala Lys Arg Ala Ala Pro Phe 
        515                 520                 525             


Asn Asn Trp Met Glu Gly Ala Met Glu Asp Leu Gln Asp Met Phe Ile 
    530                 535                 540                 


Val His Ser Ile Glu Glu Ile Gln Ser Leu Ile Xaa Ala His Glu Gln 
545                 550                 555                 560 


Phe Lys Ala Xaa Leu Pro Glu Ala Asp Gly Glu Arg Gln Ser Ile Met 
                565                 570                 575     


Ala Ile Gln Asn Glu Val Glu Lys Val Ile Gln Ser Tyr Asn Ile Arg 
            580                 585                 590         


Ile Ser Ser Ser Asn Pro Tyr Ser Xaa Val Xaa Met Asp Glu Leu Arg 
        595                 600                 605             


Xaa Lys Trp Asp Lys Val Lys Gln Leu Val Pro Ile Arg Asp Gln Ser 
    610                 615                 620                 


Leu Gln Glu Glu Leu Ala Arg Gln His Ala Asn Glu Arg Leu Arg Arg 
625                 630                 635                 640 


Gln Phe Ala Ala Gln Ala Asn Ala Ile Gly Pro Trp Ile Gln Asn Lys 
                645                 650                 655     


Met Glu Glu Ile Ala Arg Ser Ser Ile Gln Ile Xaa Gly Ala Leu Glu 
            660                 665                 670         


Asp Gln Met Asn Gln Leu Lys Gln Tyr Glu His Asn Ile Ile Asn Tyr 
        675                 680                 685             


Lys Asn Asn Ile Asp Lys Leu Glu Gly Asp His Gln Leu Ile Gln Glu 
    690                 695                 700                 


Ala Leu Val Phe Asp Asn Lys His Xaa Asn Tyr Xaa Met Glu His Ile 
705                 710                 715                 720 


Arg Val Gly Trp Glu Leu Leu Leu Xaa Xaa Ile Ala Arg Xaa Ile Asn 
                725                 730                 735     


Glu Val Glu Xaa Gln Ile Leu Xaa Arg Asp Ala Lys Gly Ile Xaa Gln 
            740                 745                 750         


Glu Gln Met Asn Glu Phe Arg Ala Ser Phe Asn His Phe Asp Arg Arg 
        755                 760                 765             


Lys Asn Gly Leu Met Asp His Glu Asp Phe Arg Ala Cys Leu Ile Ser 
    770                 775                 780                 


Met Gly Tyr Asp Leu Gly Glu Ala Glu Phe Ala Arg Ile Met Xaa Leu 
785                 790                 795                 800 


Val Asp Pro Asn Gly Gln Gly Xaa Val Xaa Phe Gln Ser Phe Ile Asp 
                805                 810                 815     


Phe Met Xaa Arg Glu Xaa Ala Asp Xaa Asp Xaa Ala Glu Gln Val Ile 
            820                 825                 830         


Ala Ser Phe Arg Ile Leu Ala Ser Asp Lys Pro Tyr Ile Leu Ala Glu 
        835                 840                 845             


Glu Leu Arg Arg Glu Leu Pro Pro Asp Gln Ala Gln Tyr Cys Ile Lys 
    850                 855                 860                 


Arg Met Pro Ala Tyr Ser Gly Pro Gly Ser Val Pro Gly Ala Leu Asp 
865                 870                 875                 880 


Tyr Ala Ala Phe Ser Ser Ala Leu Tyr Gly Glu Ser Asp Leu 
                885                 890                 


<210> 1400
<211> 686
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<400> 1400
Met Xaa Tyr Val Ser Cys Phe Tyr His Ala Phe Ala Gly Ala Glu Gln 
1               5                   10                  15      


Val Arg Gln Ser Leu Lys Ala His Ser Ala Leu Trp Lys Asp Pro Pro 
            20                  25                  30          


Pro Glu Ser Ser Xaa Cys Ser Tyr Gln Glu Met Arg Arg Ser Ser Val 
        35                  40                  45              


Asn Ser Ser Ala Met Ala Glu Xaa Ala Ala Asn Arg Ile Cys Lys Val 
    50                  55                  60                  


Leu Ala Val Asn Gln Glu Asn Glu Arg Leu Met Glu Glu Tyr Glu Arg 
65                  70                  75                  80  


Leu Ala Ser Glu Leu Leu Glu Trp Ile Arg Arg Xaa Ile Pro Trp Leu 
                85                  90                  95      


Glu Asn Arg Xaa Pro Glu Lys Xaa Met Gln Ala Met Gln Lys Lys Leu 
            100                 105                 110         


Glu Asp Phe Arg Asp Tyr Arg Arg Lys His Lys Pro Pro Lys Val Gln 
        115                 120                 125             


Glu Lys Cys Gln Leu Glu Ile Asn Phe Asn Xaa Leu Gln Xaa Lys Leu 
    130                 135                 140                 


Arg Ile Ser Asn Arg Pro Ala Phe Met Pro Ser Glu Gly Lys Met Val 
145                 150                 155                 160 


Ser Asp Ile Ala Gly Ala Trp Gln Arg Leu Glu Gln Ala Glu Lys Gly 
                165                 170                 175     


Tyr Glu Glu Trp Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu Glu 
            180                 185                 190         


His Leu Ala Glu Lys Phe Arg Gln Lys Ala Ser Xaa His Glu Xaa Trp 
        195                 200                 205             


Ala Tyr Gly Lys Glu Gln Ile Leu Leu Gln Lys Asp Tyr Glu Ser Ala 
    210                 215                 220                 


Ser Leu Xaa Glu Val Arg Ala Leu Leu Arg Lys His Glu Ala Phe Glu 
225                 230                 235                 240 


Ser Asp Leu Ala Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile 
                245                 250                 255     


Ala Gln Glu Leu Asn Glu Leu Asp Tyr His Asp Ala Val Asn Val Asn 
            260                 265                 270         


Asp Arg Cys Gln Lys Ile Cys Asp Gln Trp Asp Arg Leu Gly Xaa Leu 
        275                 280                 285             


Xaa Gln Lys Arg Arg Glu Ala Leu Glu Arg Met Glu Lys Leu Leu Glu 
    290                 295                 300                 


Xaa Ile Asp Gln Leu His Leu Glu Phe Ala Lys Arg Ala Ala Pro Phe 
305                 310                 315                 320 


Asn Asn Trp Met Glu Gly Ala Met Glu Asp Leu Gln Asp Met Phe Ile 
                325                 330                 335     


Val His Ser Ile Glu Glu Ile Gln Ser Leu Ile Xaa Ala His Glu Gln 
            340                 345                 350         


Phe Lys Ala Xaa Leu Pro Glu Ala Asp Gly Glu Arg Gln Ser Ile Met 
        355                 360                 365             


Ala Ile Gln Asn Glu Val Glu Lys Val Ile Gln Ser Tyr Asn Ile Arg 
    370                 375                 380                 


Ile Ser Ser Ser Asn Pro Tyr Ser Xaa Val Xaa Met Asp Glu Leu Arg 
385                 390                 395                 400 


Xaa Lys Trp Asp Lys Val Lys Gln Leu Val Pro Ile Arg Asp Gln Ser 
                405                 410                 415     


Leu Gln Glu Glu Leu Ala Arg Gln His Ala Asn Glu Arg Leu Arg Arg 
            420                 425                 430         


Gln Phe Ala Ala Gln Ala Asn Ala Ile Gly Pro Trp Ile Gln Asn Lys 
        435                 440                 445             


Met Glu Glu Ile Ala Arg Ser Ser Ile Gln Ile Xaa Gly Ala Leu Glu 
    450                 455                 460                 


Asp Gln Met Asn Gln Leu Lys Gln Tyr Glu His Asn Ile Ile Asn Tyr 
465                 470                 475                 480 


Lys Asn Asn Ile Asp Lys Leu Glu Gly Asp His Gln Leu Ile Gln Glu 
                485                 490                 495     


Ala Leu Val Phe Asp Asn Lys His Xaa Asn Tyr Xaa Met Glu His Ile 
            500                 505                 510         


Arg Val Gly Trp Glu Leu Leu Leu Xaa Xaa Ile Ala Arg Xaa Ile Asn 
        515                 520                 525             


Glu Val Glu Xaa Gln Ile Leu Xaa Arg Asp Ala Lys Gly Ile Xaa Gln 
    530                 535                 540                 


Glu Gln Met Asn Glu Phe Arg Ala Ser Phe Asn His Phe Asp Arg Arg 
545                 550                 555                 560 


Lys Asn Gly Leu Met Asp His Glu Asp Phe Arg Ala Cys Leu Ile Ser 
                565                 570                 575     


Met Gly Tyr Asp Leu Gly Glu Ala Glu Phe Ala Arg Ile Met Xaa Leu 
            580                 585                 590         


Val Asp Pro Asn Gly Gln Gly Xaa Val Xaa Phe Gln Ser Phe Ile Asp 
        595                 600                 605             


Phe Met Xaa Arg Glu Xaa Ala Asp Xaa Asp Xaa Ala Glu Gln Val Ile 
    610                 615                 620                 


Ala Ser Phe Arg Ile Leu Ala Ser Asp Lys Pro Tyr Ile Leu Ala Glu 
625                 630                 635                 640 


Glu Leu Arg Arg Glu Leu Pro Pro Asp Gln Ala Gln Tyr Cys Ile Lys 
                645                 650                 655     


Arg Met Pro Ala Tyr Ser Gly Pro Gly Ser Val Pro Gly Ala Leu Asp 
            660                 665                 670         


Tyr Ala Ala Phe Ser Ser Ala Leu Tyr Gly Glu Ser Asp Leu 
        675                 680                 685     


<210> 1401
<211> 944
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<400> 1401
Met Gly Ile Gly Leu Cys Val Pro Pro Ala Arg Cys Trp Lys Arg Leu 
1               5                   10                  15      


Xaa Arg Ser Ser Arg Gly Gln Pro Leu Glu Arg Pro Ala Ala Xaa Ile 
            20                  25                  30          


Ile Ile Gly Leu Ser Ile Val Glu Arg Ser Lys Gln Xaa Gln Arg Gly 
        35                  40                  45              


Pro Val Asp Phe Ser Arg Ser His Ser Ala Pro Ala Ala Glu Gln Glu 
    50                  55                  60                  


Cys Lys Pro Arg Ile Ser Ala Ala Arg Ser Xaa Pro Ala Pro Pro Ser 
65                  70                  75                  80  


Pro Ala Val Pro Gly Phe Arg Xaa Xaa Pro Cys Gln Xaa Phe Xaa Ala 
                85                  90                  95      


Trp Cys Asn Ser His Leu Arg Lys Ala Gly Xaa Gln Ile Glu Asn Ile 
            100                 105                 110         


Glu Glu Asp Phe Arg Asn Gly Leu Lys Leu Met Leu Leu Leu Glu Val 
        115                 120                 125             


Ile Ser Gly Glu Arg Leu Pro Arg Pro Asp Lys Gly Lys Met Arg Phe 
    130                 135                 140                 


His Lys Ile Ala Asn Val Asn Lys Ala Leu Asp Phe Ile Ala Ser Lys 
145                 150                 155                 160 


Gly Val Lys Leu Val Ser Ile Gly Ala Glu Glu Ile Val Asp Gly Asn 
                165                 170                 175     


Leu Lys Met Xaa Leu Gly Met Ile Trp Xaa Ile Ile Leu Arg Phe Ala 
            180                 185                 190         


Ile Gln Asp Ile Ser Val Glu Glu Xaa Ser Ala Lys Glu Gly Leu Leu 
        195                 200                 205             


Leu Trp Cys Gln Arg Lys Xaa Ala Pro Tyr Arg Asn Val Asn Val Gln 
    210                 215                 220                 


Asn Phe His Xaa Ser Trp Lys Asp Gly Leu Ala Leu Cys Ala Leu Ile 
225                 230                 235                 240 


His Arg His Arg Pro Asp Leu Ile Asp Tyr Ala Lys Leu Arg Lys Asp 
                245                 250                 255     


Asp Pro Ile Gly Asn Leu Asn Xaa Ala Phe Glu Val Ala Glu Lys Tyr 
            260                 265                 270         


Leu Asp Ile Pro Lys Met Leu Asp Ala Glu Asp Ile Val Asn Xaa Pro 
        275                 280                 285             


Lys Pro Asp Glu Lys Ala Ile Met Xaa Tyr Val Ser Cys Phe Tyr His 
    290                 295                 300                 


Ala Phe Ala Gly Ala Glu Gln Ala Glu Xaa Ala Ala Asn Arg Ile Cys 
305                 310                 315                 320 


Lys Val Leu Ala Val Asn Gln Glu Asn Glu Lys Leu Met Glu Glu Tyr 
                325                 330                 335     


Glu Lys Leu Ala Ser Glu Leu Leu Glu Trp Ile Arg Arg Xaa Val Pro 
            340                 345                 350         


Trp Leu Glu Asn Arg Val Gly Glu Pro Ser Met Ser Ala Met Gln Arg 
        355                 360                 365             


Lys Leu Glu Asp Phe Arg Asp Tyr Arg Arg Leu His Lys Pro Pro Arg 
    370                 375                 380                 


Ile Gln Glu Lys Cys Gln Leu Glu Ile Asn Phe Asn Xaa Leu Gln Xaa 
385                 390                 395                 400 


Lys Leu Arg Leu Ser His Arg Pro Ala Phe Met Pro Ser Glu Gly Lys 
                405                 410                 415     


Leu Val Ser Asp Ile Ala Asn Ala Trp Arg Gly Leu Glu Gln Val Glu 
            420                 425                 430         


Lys Gly Tyr Glu Asp Trp Leu Leu Ser Glu Ile Arg Arg Leu Gln Arg 
        435                 440                 445             


Leu Gln His Leu Ala Glu Lys Phe Arg Gln Lys Ala Ser Leu His Glu 
    450                 455                 460                 


Ala Trp Xaa Arg Gly Lys Glu Glu Met Leu Ser Gln Arg Asp Tyr Asp 
465                 470                 475                 480 


Ser Ala Leu Leu Gln Glu Val Arg Ala Leu Leu Arg Arg His Glu Ala 
                485                 490                 495     


Phe Glu Ser Asp Leu Ala Ala His Gln Asp Arg Val Glu His Ile Ala 
            500                 505                 510         


Ala Leu Ala Gln Glu Leu Asn Glu Leu Asp Tyr His Glu Ala Ala Ser 
        515                 520                 525             


Val Asn Ser Arg Cys Gln Ala Ile Cys Asp Gln Trp Asp Asn Leu Gly 
    530                 535                 540                 


Xaa Leu Xaa Gln Lys Arg Arg Asp Ala Leu Glu Arg Met Glu Lys Leu 
545                 550                 555                 560 


Leu Glu Xaa Ile Asp Arg Leu Gln Leu Glu Phe Ala Arg Arg Ala Ala 
                565                 570                 575     


Pro Phe Asn Asn Trp Leu Asp Gly Ala Val Glu Asp Leu Gln Asp Val 
            580                 585                 590         


Trp Leu Val His Ser Val Glu Glu Xaa Gln Ser Leu Leu Xaa Ala His 
        595                 600                 605             


Asp Gln Phe Lys Ala Xaa Leu Pro Glu Ala Asp Arg Glu Arg Gly Ala 
    610                 615                 620                 


Ile Met Gly Ile Gln Gly Glu Ile Gln Lys Ile Cys Gln Xaa Tyr Gly 
625                 630                 635                 640 


Leu Arg Pro Cys Ser Xaa Asn Pro Tyr Ile Xaa Leu Ser Pro Gln Asp 
                645                 650                 655     


Ile Asn Xaa Lys Trp Asp Met Val Arg Lys Leu Val Pro Ser Cys Asp 
            660                 665                 670         


Gln Xaa Leu Gln Glu Glu Leu Ala Arg Gln Gln Val Asn Glu Arg Leu 
        675                 680                 685             


Arg Arg Gln Phe Ala Ala Gln Ala Asn Ala Ile Gly Pro Trp Ile Gln 
    690                 695                 700                 


Ala Lys Val Glu Glu Val Gly Arg Leu Ala Ala Gly Leu Ala Gly Ser 
705                 710                 715                 720 


Leu Glu Glu Gln Met Ala Gly Leu Arg Gln Gln Glu Gln Asn Ile Ile 
                725                 730                 735     


Asn Tyr Lys Xaa Asn Ile Asp Arg Leu Glu Gly Asp His Gln Leu Leu 
            740                 745                 750         


Gln Glu Ser Leu Val Phe Asp Asn Lys His Xaa Val Tyr Ser Met Glu 
        755                 760                 765             


His Ile Arg Val Gly Trp Glu Gln Leu Leu Xaa Ser Ile Ala Arg Xaa 
    770                 775                 780                 


Ile Asn Glu Val Glu Asn Gln Val Leu Xaa Arg Asp Ala Lys Gly Leu 
785                 790                 795                 800 


Ser Gln Glu Gln Leu Asn Glu Phe Arg Ala Ser Phe Asn His Phe Asp 
                805                 810                 815     


Arg Lys Gln Asn Gly Met Met Glu Pro Asp Asp Phe Arg Ala Cys Leu 
            820                 825                 830         


Ile Ser Met Gly Tyr Asp Leu Gly Glu Val Glu Phe Ala Arg Ile Met 
        835                 840                 845             


Xaa Met Val Asp Pro Asn Ala Ala Gly Val Val Xaa Phe Gln Ala Phe 
    850                 855                 860                 


Ile Asp Phe Met Xaa Arg Glu Xaa Ala Glu Xaa Asp Xaa Xaa Glu Gln 
865                 870                 875                 880 


Val Val Ala Ser Phe Lys Ile Leu Ala Gly Asp Lys Asn Tyr Ile Xaa 
                885                 890                 895     


Pro Glu Glu Leu Arg Arg Glu Leu Pro Ala Lys Gln Ala Glu Tyr Cys 
            900                 905                 910         


Ile Arg Arg Met Val Pro Tyr Lys Gly Ser Gly Ala Pro Ala Gly Ala 
        915                 920                 925             


Leu Asp Tyr Val Ala Phe Ser Ser Ala Leu Tyr Gly Glu Ser Asp Leu 
    930                 935                 940                 


<210> 1402
<211> 72
<212> PRT
<213> Homo sapiens

<400> 1402
Met Met Met Val Met Gln Pro Glu Gly Leu Gly Ala Gly Glu Gly Arg 
1               5                   10                  15      


Phe Ala Gly Gly Gly Gly Gly Gly Glu Tyr Met Glu Gln Glu Glu Asp 
            20                  25                  30          


Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp Glu Lys Gln Gln Arg 
        35                  40                  45              


Lys Glu Asn Glu Ser Ser Glu Arg Glu Arg Asp Trp Pro Arg Met His 
    50                  55                  60                  


Ser Lys Ser Val Ala Glu Leu Ser 
65                  70          


<210> 1403
<211> 901
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<400> 1403
Met Met Met Val Met Gln Pro Glu Gly Leu Gly Ala Gly Glu Gly Arg 
1               5                   10                  15      


Phe Ala Gly Gly Gly Gly Gly Gly Glu Tyr Met Glu Gln Glu Glu Asp 
            20                  25                  30          


Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp Glu Lys Gln Gln Arg 
        35                  40                  45              


Lys Xaa Phe Xaa Ala Trp Cys Asn Ser His Leu Arg Lys Ala Gly Xaa 
    50                  55                  60                  


Gln Ile Glu Asn Ile Glu Glu Asp Phe Arg Asn Gly Leu Lys Leu Met 
65                  70                  75                  80  


Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu Pro Arg Pro Asp Lys 
                85                  90                  95      


Gly Lys Met Arg Phe His Lys Ile Ala Asn Val Asn Lys Ala Leu Asp 
            100                 105                 110         


Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser Ile Gly Ala Glu Glu 
        115                 120                 125             


Ile Val Asp Gly Asn Leu Lys Met Xaa Leu Gly Met Ile Trp Xaa Ile 
    130                 135                 140                 


Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val Glu Glu Xaa Ser Ala 
145                 150                 155                 160 


Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys Xaa Ala Pro Tyr Arg 
                165                 170                 175     


Asn Val Asn Val Gln Asn Phe His Xaa Ser Trp Lys Asp Gly Leu Ala 
            180                 185                 190         


Leu Cys Ala Leu Ile His Arg His Arg Pro Asp Leu Ile Asp Tyr Ala 
        195                 200                 205             


Lys Leu Arg Lys Asp Asp Pro Ile Gly Asn Leu Asn Xaa Ala Phe Glu 
    210                 215                 220                 


Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met Leu Asp Ala Glu Asp 
225                 230                 235                 240 


Ile Val Asn Xaa Pro Lys Pro Asp Glu Lys Ala Ile Met Xaa Tyr Val 
                245                 250                 255     


Ser Cys Phe Tyr His Ala Phe Ala Gly Ala Glu Gln Ala Glu Xaa Ala 
            260                 265                 270         


Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn Gln Glu Asn Glu Lys 
        275                 280                 285             


Leu Met Glu Glu Tyr Glu Lys Leu Ala Ser Glu Leu Leu Glu Trp Ile 
    290                 295                 300                 


Arg Arg Xaa Val Pro Trp Leu Glu Asn Arg Val Gly Glu Pro Ser Met 
305                 310                 315                 320 


Ser Ala Met Gln Arg Lys Leu Glu Asp Phe Arg Asp Tyr Arg Arg Leu 
                325                 330                 335     


His Lys Pro Pro Arg Ile Gln Glu Lys Cys Gln Leu Glu Ile Asn Phe 
            340                 345                 350         


Asn Xaa Leu Gln Xaa Lys Leu Arg Leu Ser His Arg Pro Ala Phe Met 
        355                 360                 365             


Pro Ser Glu Gly Lys Leu Val Ser Asp Ile Ala Asn Ala Trp Arg Gly 
    370                 375                 380                 


Leu Glu Gln Val Glu Lys Gly Tyr Glu Asp Trp Leu Leu Ser Glu Ile 
385                 390                 395                 400 


Arg Arg Leu Gln Arg Leu Gln His Leu Ala Glu Lys Phe Arg Gln Lys 
                405                 410                 415     


Ala Ser Leu His Glu Ala Trp Xaa Arg Gly Lys Glu Glu Met Leu Ser 
            420                 425                 430         


Gln Arg Asp Tyr Asp Ser Ala Leu Leu Gln Glu Val Arg Ala Leu Leu 
        435                 440                 445             


Arg Arg His Glu Ala Phe Glu Ser Asp Leu Ala Ala His Gln Asp Arg 
    450                 455                 460                 


Val Glu His Ile Ala Ala Leu Ala Gln Glu Leu Asn Glu Leu Asp Tyr 
465                 470                 475                 480 


His Glu Ala Ala Ser Val Asn Ser Arg Cys Gln Ala Ile Cys Asp Gln 
                485                 490                 495     


Trp Asp Asn Leu Gly Xaa Leu Xaa Gln Lys Arg Arg Asp Ala Leu Glu 
            500                 505                 510         


Arg Met Glu Lys Leu Leu Glu Xaa Ile Asp Arg Leu Gln Leu Glu Phe 
        515                 520                 525             


Ala Arg Arg Ala Ala Pro Phe Asn Asn Trp Leu Asp Gly Ala Val Glu 
    530                 535                 540                 


Asp Leu Gln Asp Val Trp Leu Val His Ser Val Glu Glu Xaa Gln Ser 
545                 550                 555                 560 


Leu Leu Xaa Ala His Asp Gln Phe Lys Ala Xaa Leu Pro Glu Ala Asp 
                565                 570                 575     


Arg Glu Arg Gly Ala Ile Met Gly Ile Gln Gly Glu Ile Gln Lys Ile 
            580                 585                 590         


Cys Gln Xaa Tyr Gly Leu Arg Pro Cys Ser Xaa Asn Pro Tyr Ile Xaa 
        595                 600                 605             


Leu Ser Pro Gln Asp Ile Asn Xaa Lys Trp Asp Met Val Arg Lys Leu 
    610                 615                 620                 


Val Pro Ser Cys Asp Gln Xaa Leu Gln Glu Glu Leu Ala Arg Gln Gln 
625                 630                 635                 640 


Val Asn Glu Arg Leu Arg Arg Gln Phe Ala Ala Gln Ala Asn Ala Ile 
                645                 650                 655     


Gly Pro Trp Ile Gln Ala Lys Val Glu Glu Val Gly Arg Leu Ala Ala 
            660                 665                 670         


Gly Leu Ala Gly Ser Leu Glu Glu Gln Met Ala Gly Leu Arg Gln Gln 
        675                 680                 685             


Glu Gln Asn Ile Ile Asn Tyr Lys Xaa Asn Ile Asp Arg Leu Glu Gly 
    690                 695                 700                 


Asp His Gln Leu Leu Gln Glu Ser Leu Val Phe Asp Asn Lys His Xaa 
705                 710                 715                 720 


Val Tyr Ser Met Glu His Ile Arg Val Gly Trp Glu Gln Leu Leu Xaa 
                725                 730                 735     


Ser Ile Ala Arg Xaa Ile Asn Glu Val Glu Asn Gln Val Leu Xaa Arg 
            740                 745                 750         


Asp Ala Lys Gly Leu Ser Gln Glu Gln Leu Asn Glu Phe Arg Ala Ser 
        755                 760                 765             


Phe Asn His Phe Asp Arg Lys Gln Asn Gly Met Met Glu Pro Asp Asp 
    770                 775                 780                 


Phe Arg Ala Cys Leu Ile Ser Met Gly Tyr Asp Leu Gly Glu Val Glu 
785                 790                 795                 800 


Phe Ala Arg Ile Met Xaa Met Val Asp Pro Asn Ala Ala Gly Val Val 
                805                 810                 815     


Xaa Phe Gln Ala Phe Ile Asp Phe Met Xaa Arg Glu Xaa Ala Glu Xaa 
            820                 825                 830         


Asp Xaa Xaa Glu Gln Val Val Ala Ser Phe Lys Ile Leu Ala Gly Asp 
        835                 840                 845             


Lys Asn Tyr Ile Xaa Pro Glu Glu Leu Arg Arg Glu Leu Pro Ala Lys 
    850                 855                 860                 


Gln Ala Glu Tyr Cys Ile Arg Arg Met Val Pro Tyr Lys Gly Ser Gly 
865                 870                 875                 880 


Ala Pro Ala Gly Ala Leu Asp Tyr Val Ala Phe Ser Ser Ala Leu Tyr 
                885                 890                 895     


Gly Glu Ser Asp Leu 
            900     


<210> 1404
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<400> 1404
Ala Leu Ile His Arg His Arg Pro Glu Leu Ile Glu Tyr Asp Lys Leu 
1               5                   10                  15      


Arg Lys Asp Asp Pro Val Xaa Asn Leu Asn Asn Ala Phe Glu Val Ala 
            20                  25                  30          


Glu Lys Tyr Leu Asp Ile Pro Lys Met Leu Asp Ala Glu Asp Ile Val 
        35                  40                  45              


Gly Xaa Leu Arg Pro Asp Glu Lys Ala Ile Met Xaa Tyr Val Ser Cys 
    50                  55                  60                  


Phe Tyr His Ala Phe Ser Gly Ala Gln Lys Ala Glu Xaa Ala Ala Asn 
65                  70                  75                  80  


Arg Ile Cys Lys Val Leu Ala Val Asn Gln Glu Asn Glu His Leu Met 
                85                  90                  95      


Glu Asp Tyr Glu Lys Leu Ala Ser Asp Leu Leu Glu Trp Ile Arg Arg 
            100                 105                 110         


Xaa Ile Pro Trp Leu Glu Asp Arg Val Pro Gln Lys Xaa Ile Gln Glu 
        115                 120                 125             


Met Gln Gln Lys Leu Glu Asp Phe Arg Asp Tyr Arg Arg Val His Lys 
    130                 135                 140                 


Pro Pro Lys Val Gln Glu Lys Cys Gln Leu Glu Ile Asn Phe Asn Xaa 
145                 150                 155                 160 


Leu Gln Xaa Lys Leu Arg Leu Ser Asn Arg Pro Ala Phe Met Pro Ser 
                165                 170                 175     


Glu Gly Lys Met Val Ser 
            180         


<210> 1405
<211> 342
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<400> 1405
Gly Leu Ile Ser Ala His Asp Gln Phe Lys Ser Xaa Leu Pro Asp Ala 
1               5                   10                  15      


Asp Arg Glu Arg Glu Ala Ile Leu Ala Ile His Lys Glu Ala Gln Arg 
            20                  25                  30          


Ile Ala Glu Ser Asn His Ile Lys Leu Ser Gly Ser Asn Pro Tyr Xaa 
        35                  40                  45              


Xaa Val Xaa Pro Gln Ile Ile Asn Ser Lys Trp Glu Lys Val Gln Gln 
    50                  55                  60                  


Leu Val Pro Lys Arg Asp His Ala Leu Leu Glu Glu Gln Ser Lys Gln 
65                  70                  75                  80  


Gln Ser Asn Glu His Leu Arg Arg Gln Phe Ala Ser Gln Ala Asn Val 
                85                  90                  95      


Val Gly Pro Trp Ile Gln Xaa Lys Met Glu Glu Ile Gly Arg Ile Ser 
            100                 105                 110         


Ile Glu Met Asn Gly Xaa Leu Glu Asp Gln Leu Ser His Leu Lys Gln 
        115                 120                 125             


Tyr Glu Arg Ser Ile Val Asp Tyr Lys Pro Asn Leu Asp Leu Leu Glu 
    130                 135                 140                 


Gln Gln His Gln Leu Ile Gln Glu Ala Leu Ile Phe Asp Asn Lys His 
145                 150                 155                 160 


Xaa Asn Tyr Xaa Met Glu His Ile Arg Val Gly Trp Glu Gln Leu Leu 
                165                 170                 175     


Xaa Xaa Ile Ala Arg Xaa Ile Asn Glu Val Glu Asn Gln Ile Leu Xaa 
            180                 185                 190         


Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Gln Glu Phe Arg Ala 
        195                 200                 205             


Ser Phe Asn His Phe Asp Lys Lys Gln Xaa Gly Ser Met Asp Ser Asp 
    210                 215                 220                 


Asp Phe Arg Ala Leu Leu Ile Ser Xaa Gly Tyr Ser Leu Gly Glu Ala 
225                 230                 235                 240 


Glu Phe Asn Arg Ile Met Ser Leu Val Asp Pro Asn His Ser Gly Leu 
                245                 250                 255     


Val Xaa Phe Gln Ala Phe Ile Asp Phe Met Ser Arg Glu Xaa Xaa Asp 
            260                 265                 270         


Xaa Asp Xaa Ala Asp Gln Val Ile Ala Ser Phe Lys Val Leu Ala Gly 
        275                 280                 285             


Asp Lys Asn Phe Ile Xaa Ala Glu Glu Leu Arg Arg Glu Leu Pro Pro 
    290                 295                 300                 


Asp Gln Ala Glu Tyr Cys Ile Ala Arg Met Ala Pro Tyr Gln Gly Pro 
305                 310                 315                 320 


Asp Ala Val Pro Gly Ala Leu Asp Tyr Lys Ser Phe Ser Xaa Ala Leu 
                325                 330                 335     


Tyr Gly Glu Ser Asp Leu 
            340         


<210> 1406
<211> 692
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<400> 1406
Met Val Asp Tyr His Ala Ala Asn Gln Ser Tyr Gln Tyr Gly Pro Ser 
1               5                   10                  15      


Ser Ala Gly Asn Gly Ala Gly Gly Gly Gly Ser Met Gly Asp Tyr Met 
            20                  25                  30          


Ala Gln Glu Asp Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp 
        35                  40                  45              


Glu Lys Gln Gln Arg Lys Ala Glu Xaa Ala Ala Asn Arg Ile Cys Lys 
    50                  55                  60                  


Val Leu Ala Val Asn Gln Glu Asn Glu His Leu Met Glu Asp Tyr Glu 
65                  70                  75                  80  


Lys Leu Ala Ser Asp Leu Leu Glu Trp Ile Arg Arg Xaa Ile Pro Trp 
                85                  90                  95      


Leu Glu Asp Arg Val Pro Gln Lys Xaa Ile Gln Glu Met Gln Gln Lys 
            100                 105                 110         


Leu Glu Asp Phe Arg Asp Tyr Arg Arg Val His Lys Pro Pro Lys Val 
        115                 120                 125             


Gln Glu Lys Cys Gln Leu Glu Ile Asn Phe Asn Xaa Leu Gln Xaa Lys 
    130                 135                 140                 


Leu Arg Leu Ser Asn Arg Pro Ala Phe Met Pro Ser Glu Gly Lys Met 
145                 150                 155                 160 


Val Ser Asp Ile Asn Asn Gly Trp Gln His Leu Glu Gln Ala Glu Lys 
                165                 170                 175     


Gly Tyr Glu Glu Trp Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu 
            180                 185                 190         


Asp His Leu Ala Glu Lys Phe Arg Gln Lys Ala Ser Ile His Glu Ala 
        195                 200                 205             


Trp Xaa Asp Gly Lys Glu Ala Met Leu Lys His Arg Asp Tyr Glu Xaa 
    210                 215                 220                 


Ala Xaa Leu Ser Asp Ile Lys Ala Leu Ile Arg Lys His Glu Ala Phe 
225                 230                 235                 240 


Glu Ser Asp Leu Ala Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala 
                245                 250                 255     


Ile Ala Gln Glu Leu Asn Glu Leu Asp Tyr Tyr Asp Ser His Asn Val 
            260                 265                 270         


Asn Xaa Arg Cys Gln Lys Ile Cys Asp Gln Trp Asp Ala Leu Gly Ser 
        275                 280                 285             


Leu Xaa His Ser Arg Arg Glu Ala Leu Glu Lys Xaa Glu Lys Gln Leu 
    290                 295                 300                 


Glu Ala Ile Asp Gln Leu His Leu Glu Tyr Ala Lys Arg Ala Ala Pro 
305                 310                 315                 320 


Phe Asn Asn Trp Met Glu Ser Ala Met Glu Asp Leu Gln Asp Met Phe 
                325                 330                 335     


Ile Val His Xaa Ile Glu Glu Ile Glu Gly Leu Ile Ser Ala His Asp 
            340                 345                 350         


Gln Phe Lys Ser Xaa Leu Pro Asp Ala Asp Arg Glu Arg Glu Ala Ile 
        355                 360                 365             


Leu Ala Ile His Lys Glu Ala Gln Arg Ile Ala Glu Ser Asn His Ile 
    370                 375                 380                 


Lys Leu Ser Gly Ser Asn Pro Tyr Xaa Xaa Val Xaa Pro Gln Ile Ile 
385                 390                 395                 400 


Asn Ser Lys Trp Glu Lys Val Gln Gln Leu Val Pro Lys Arg Asp His 
                405                 410                 415     


Ala Leu Leu Glu Glu Gln Ser Lys Gln Gln Ser Asn Glu His Leu Arg 
            420                 425                 430         


Arg Gln Phe Ala Ser Gln Ala Asn Val Val Gly Pro Trp Ile Gln Xaa 
        435                 440                 445             


Lys Met Glu Glu Ile Gly Arg Ile Ser Ile Glu Met Asn Gly Xaa Leu 
    450                 455                 460                 


Glu Asp Gln Leu Ser His Leu Lys Gln Tyr Glu Arg Ser Ile Val Asp 
465                 470                 475                 480 


Tyr Lys Pro Asn Leu Asp Leu Leu Glu Gln Gln His Gln Leu Ile Gln 
                485                 490                 495     


Glu Ala Leu Ile Phe Asp Asn Lys His Xaa Asn Tyr Xaa Met Glu His 
            500                 505                 510         


Ile Arg Val Gly Trp Glu Gln Leu Leu Xaa Xaa Ile Ala Arg Xaa Ile 
        515                 520                 525             


Asn Glu Val Glu Asn Gln Ile Leu Xaa Arg Asp Ala Lys Gly Ile Ser 
    530                 535                 540                 


Gln Glu Gln Met Gln Glu Phe Arg Ala Ser Phe Asn His Phe Asp Lys 
545                 550                 555                 560 


Asp His Gly Gly Ala Leu Gly Pro Glu Glu Phe Lys Ala Cys Leu Ile 
                565                 570                 575     


Ser Leu Gly Tyr Asp Val Glu Asn Asp Arg Gln Gly Glu Ala Glu Phe 
            580                 585                 590         


Asn Arg Ile Met Ser Leu Val Asp Pro Asn His Ser Gly Leu Val Xaa 
        595                 600                 605             


Phe Gln Ala Phe Ile Asp Phe Met Ser Arg Glu Xaa Xaa Asp Xaa Asp 
    610                 615                 620                 


Xaa Ala Asp Gln Val Ile Ala Ser Phe Lys Val Leu Ala Gly Asp Lys 
625                 630                 635                 640 


Asn Phe Ile Xaa Ala Glu Glu Leu Arg Arg Glu Leu Pro Pro Asp Gln 
                645                 650                 655     


Ala Glu Tyr Cys Ile Ala Arg Met Ala Pro Tyr Gln Gly Pro Asp Ala 
            660                 665                 670         


Val Pro Gly Ala Leu Asp Tyr Lys Ser Phe Ser Xaa Ala Leu Tyr Gly 
        675                 680                 685             


Glu Ser Asp Leu 
    690         


<210> 1407
<211> 521
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<400> 1407
Met Val Asp Tyr His Ala Ala Asn Gln Ser Tyr Gln Tyr Gly Pro Ser 
1               5                   10                  15      


Ser Ala Gly Asn Gly Ala Gly Gly Gly Gly Ser Met Gly Asp Tyr Met 
            20                  25                  30          


Ala Gln Glu Asp Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp 
        35                  40                  45              


Glu Lys Gln Gln Arg Lys Xaa Phe Xaa Ala Trp Cys Asn Ser His Leu 
    50                  55                  60                  


Arg Lys Ala Gly Xaa Gln Ile Glu Asn Ile Asp Glu Asp Phe Arg Asp 
65                  70                  75                  80  


Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Glu Leu Asp Tyr Tyr 
                85                  90                  95      


Asp Ser His Asn Val Asn Xaa Arg Cys Gln Lys Ile Cys Asp Gln Trp 
            100                 105                 110         


Asp Ala Leu Gly Ser Leu Xaa His Ser Arg Arg Glu Ala Leu Glu Lys 
        115                 120                 125             


Xaa Glu Lys Gln Leu Glu Ala Ile Asp Gln Leu His Leu Glu Tyr Ala 
    130                 135                 140                 


Lys Arg Ala Ala Pro Phe Asn Asn Trp Met Glu Ser Ala Met Glu Asp 
145                 150                 155                 160 


Leu Gln Asp Met Phe Ile Val His Xaa Ile Glu Glu Ile Glu Gly Leu 
                165                 170                 175     


Ile Ser Ala His Asp Gln Phe Lys Ser Xaa Leu Pro Asp Ala Asp Arg 
            180                 185                 190         


Glu Arg Glu Ala Ile Leu Ala Ile His Lys Glu Ala Gln Arg Ile Ala 
        195                 200                 205             


Glu Ser Asn His Ile Lys Leu Ser Gly Ser Asn Pro Tyr Xaa Xaa Val 
    210                 215                 220                 


Xaa Pro Gln Ile Ile Asn Ser Lys Trp Glu Lys Val Gln Gln Leu Val 
225                 230                 235                 240 


Pro Lys Arg Asp His Ala Leu Leu Glu Glu Gln Ser Lys Gln Gln Ser 
                245                 250                 255     


Asn Glu His Leu Arg Arg Gln Phe Ala Ser Gln Ala Asn Val Val Gly 
            260                 265                 270         


Pro Trp Ile Gln Xaa Lys Met Glu Glu Ile Gly Arg Ile Ser Ile Glu 
        275                 280                 285             


Met Asn Gly Xaa Leu Glu Asp Gln Leu Ser His Leu Lys Gln Tyr Glu 
    290                 295                 300                 


Arg Ser Ile Val Asp Tyr Lys Pro Asn Leu Asp Leu Leu Glu Gln Gln 
305                 310                 315                 320 


His Gln Leu Ile Gln Glu Ala Leu Ile Phe Asp Asn Lys His Xaa Asn 
                325                 330                 335     


Tyr Xaa Met Glu His Ile Arg Val Gly Trp Glu Gln Leu Leu Xaa Xaa 
            340                 345                 350         


Ile Ala Arg Xaa Ile Asn Glu Val Glu Asn Gln Ile Leu Xaa Arg Asp 
        355                 360                 365             


Ala Lys Gly Ile Ser Gln Glu Gln Met Gln Glu Phe Arg Ala Ser Phe 
    370                 375                 380                 


Asn His Phe Asp Lys Asp His Gly Gly Ala Leu Gly Pro Glu Glu Phe 
385                 390                 395                 400 


Lys Ala Cys Leu Ile Ser Leu Gly Tyr Asp Val Glu Asn Asp Arg Gln 
                405                 410                 415     


Gly Glu Ala Glu Phe Asn Arg Ile Met Ser Leu Val Asp Pro Asn His 
            420                 425                 430         


Ser Gly Leu Val Xaa Phe Gln Ala Phe Ile Asp Phe Met Ser Arg Glu 
        435                 440                 445             


Xaa Xaa Asp Xaa Asp Xaa Ala Asp Gln Val Ile Ala Ser Phe Lys Val 
    450                 455                 460                 


Leu Ala Gly Asp Lys Asn Phe Ile Xaa Ala Glu Glu Leu Arg Arg Glu 
465                 470                 475                 480 


Leu Pro Pro Asp Gln Ala Glu Tyr Cys Ile Ala Arg Met Ala Pro Tyr 
                485                 490                 495     


Gln Gly Pro Asp Ala Val Pro Gly Ala Leu Asp Tyr Lys Ser Phe Ser 
            500                 505                 510         


Xaa Ala Leu Tyr Gly Glu Ser Asp Leu 
        515                 520     


<210> 1408
<211> 911
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<400> 1408
Met Val Asp Tyr His Ala Ala Asn Gln Ser Tyr Gln Tyr Gly Pro Ser 
1               5                   10                  15      


Ser Ala Gly Asn Gly Ala Gly Gly Gly Gly Ser Met Gly Asp Tyr Met 
            20                  25                  30          


Ala Gln Glu Asp Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp 
        35                  40                  45              


Glu Lys Gln Gln Arg Lys Xaa Phe Xaa Ala Trp Cys Asn Ser His Leu 
    50                  55                  60                  


Arg Lys Ala Gly Xaa Gln Ile Glu Asn Ile Asp Glu Asp Phe Arg Asp 
65                  70                  75                  80  


Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu 
                85                  90                  95      


Pro Lys Pro Glu Arg Gly Lys Met Arg Val His Lys Ile Asn Asn Val 
            100                 105                 110         


Asn Lys Ala Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser 
        115                 120                 125             


Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Ala Lys Met Xaa Leu Gly 
    130                 135                 140                 


Met Ile Trp Xaa Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val 
145                 150                 155                 160 


Glu Glu Xaa Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys 
                165                 170                 175     


Xaa Ala Pro Tyr Lys Asn Val Asn Val Gln Asn Phe His Ile Ser Trp 
            180                 185                 190         


Lys Asp Gly Leu Ala Phe Asn Ala Leu Ile His Arg His Arg Pro Glu 
        195                 200                 205             


Leu Ile Glu Tyr Asp Lys Leu Arg Lys Asp Asp Pro Val Xaa Asn Leu 
    210                 215                 220                 


Asn Asn Ala Phe Glu Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met 
225                 230                 235                 240 


Leu Asp Ala Glu Asp Ile Val Asn Xaa Ala Arg Pro Asp Glu Lys Ala 
                245                 250                 255     


Ile Met Xaa Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln 
            260                 265                 270         


Lys Ala Glu Xaa Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn 
        275                 280                 285             


Gln Glu Asn Glu His Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp 
    290                 295                 300                 


Leu Leu Glu Trp Ile Arg Arg Xaa Ile Pro Trp Leu Glu Asp Arg Val 
305                 310                 315                 320 


Pro Gln Lys Xaa Ile Gln Glu Met Gln Gln Lys Leu Glu Asp Phe Arg 
                325                 330                 335     


Asp Tyr Arg Arg Val His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln 
            340                 345                 350         


Leu Glu Ile Asn Phe Asn Xaa Leu Gln Xaa Lys Leu Arg Leu Ser Asn 
        355                 360                 365             


Arg Pro Ala Phe Met Pro Ser Glu Gly Lys Met Val Ser Asp Ile Asn 
    370                 375                 380                 


Asn Gly Trp Gln His Leu Glu Gln Ala Glu Lys Gly Tyr Glu Glu Trp 
385                 390                 395                 400 


Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu Asp His Leu Ala Glu 
                405                 410                 415     


Lys Phe Arg Gln Lys Ala Ser Ile His Glu Ala Trp Xaa Asp Gly Lys 
            420                 425                 430         


Glu Ala Met Leu Lys His Arg Asp Tyr Glu Xaa Ala Xaa Leu Ser Asp 
        435                 440                 445             


Ile Lys Ala Leu Ile Arg Lys His Glu Ala Phe Glu Ser Asp Leu Ala 
    450                 455                 460                 


Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu 
465                 470                 475                 480 


Asn Glu Leu Asp Tyr Tyr Asp Ser His Asn Val Asn Xaa Arg Cys Gln 
                485                 490                 495     


Lys Ile Cys Asp Gln Trp Asp Ala Leu Gly Ser Leu Xaa His Ser Arg 
            500                 505                 510         


Arg Glu Ala Leu Glu Lys Xaa Glu Lys Gln Leu Glu Ala Ile Asp Gln 
        515                 520                 525             


Leu His Leu Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met 
    530                 535                 540                 


Glu Ser Ala Met Glu Asp Leu Gln Asp Met Phe Ile Val His Xaa Ile 
545                 550                 555                 560 


Glu Glu Ile Glu Gly Leu Ile Ser Ala His Asp Gln Phe Lys Ser Xaa 
                565                 570                 575     


Leu Pro Asp Ala Asp Arg Glu Arg Glu Ala Ile Leu Ala Ile His Lys 
            580                 585                 590         


Glu Ala Gln Arg Ile Ala Glu Ser Asn His Ile Lys Leu Ser Gly Ser 
        595                 600                 605             


Asn Pro Tyr Xaa Xaa Val Xaa Pro Gln Ile Ile Asn Ser Lys Trp Glu 
    610                 615                 620                 


Lys Val Gln Gln Leu Val Pro Lys Arg Asp His Ala Leu Leu Glu Glu 
625                 630                 635                 640 


Gln Ser Lys Gln Gln Ser Asn Glu His Leu Arg Arg Gln Phe Ala Ser 
                645                 650                 655     


Gln Ala Asn Val Val Gly Pro Trp Ile Gln Xaa Lys Met Glu Glu Ile 
            660                 665                 670         


Gly Arg Ile Ser Ile Glu Met Asn Gly Xaa Leu Glu Asp Gln Leu Ser 
        675                 680                 685             


His Leu Lys Gln Tyr Glu Arg Ser Ile Val Asp Tyr Lys Pro Asn Leu 
    690                 695                 700                 


Asp Leu Leu Glu Gln Gln His Gln Leu Ile Gln Glu Ala Leu Ile Phe 
705                 710                 715                 720 


Asp Asn Lys His Xaa Asn Tyr Xaa Met Glu His Ile Arg Val Gly Trp 
                725                 730                 735     


Glu Gln Leu Leu Xaa Xaa Ile Ala Arg Xaa Ile Asn Glu Val Glu Asn 
            740                 745                 750         


Gln Ile Leu Xaa Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Gln 
        755                 760                 765             


Glu Phe Arg Ala Ser Phe Asn His Phe Asp Lys Asp His Gly Gly Ala 
    770                 775                 780                 


Leu Gly Pro Glu Glu Phe Lys Ala Cys Leu Ile Ser Leu Gly Tyr Asp 
785                 790                 795                 800 


Val Glu Asn Asp Arg Gln Gly Glu Ala Glu Phe Asn Arg Ile Met Ser 
                805                 810                 815     


Leu Val Asp Pro Asn His Ser Gly Leu Val Xaa Phe Gln Ala Phe Ile 
            820                 825                 830         


Asp Phe Met Ser Arg Glu Xaa Xaa Asp Xaa Asp Xaa Ala Asp Gln Val 
        835                 840                 845             


Ile Ala Ser Phe Lys Val Leu Ala Gly Asp Lys Asn Phe Ile Xaa Ala 
    850                 855                 860                 


Glu Glu Leu Arg Arg Glu Leu Pro Pro Asp Gln Ala Glu Tyr Cys Ile 
865                 870                 875                 880 


Ala Arg Met Ala Pro Tyr Gln Gly Pro Asp Ala Val Pro Gly Ala Leu 
                885                 890                 895     


Asp Tyr Lys Ser Phe Ser Xaa Ala Leu Tyr Gly Glu Ser Asp Leu 
            900                 905                 910     


<210> 1409
<211> 105
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<400> 1409
Xaa Gly Gly Met Val Asp Tyr His Ala Ala Asn Gln Ser Tyr Gln Tyr 
1               5                   10                  15      


Gly Pro Ser Ser Ala Gly Asn Gly Ala Gly Gly Gly Gly Ser Met Gly 
            20                  25                  30          


Asp Tyr Met Ala Gln Glu Asp Asp Trp Asp Arg Asp Leu Leu Leu Asp 
        35                  40                  45              


Pro Ala Trp Glu Lys Gln Gln Arg Lys Xaa Phe Xaa Ala Trp Cys Asn 
    50                  55                  60                  


Ser His Leu Arg Lys Ala Gly Xaa Gln Ile Glu Asn Ile Asp Glu Asp 
65                  70                  75                  80  


Phe Arg Asp Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser Glu 
                85                  90                  95      


Glu Leu Ser Trp Gln Xaa Gly Pro Pro 
            100                 105 


<210> 1410
<211> 53
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<400> 1410
Met Asp Ser Gln Gly Arg Lys Val Val Val Cys Asp Asn Gly Xaa Gly 
1               5                   10                  15      


Phe Val Lys Cys Gly Tyr Ala Gly Ser Asn Phe Pro Glu His Ile Phe 
            20                  25                  30          


Pro Ala Leu Val Gly Arg Pro Ile Ile Arg Ser Xaa Xaa Lys Val Gly 
        35                  40                  45              


Asn Ile Glu Ile Lys 
    50              


<210> 1411
<211> 65
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<400> 1411
Met Asp Ser Gln Gly Arg Lys Val Val Val Cys Asp Asn Gly Xaa Gly 
1               5                   10                  15      


Phe Val Lys Cys Gly Tyr Ala Gly Ser Asn Phe Pro Glu His Ile Phe 
            20                  25                  30          


Pro Ala Leu Val Gly Arg Pro Ile Ile Arg Ser Xaa Xaa Lys Val Gly 
        35                  40                  45              


Asn Ile Glu Ile Lys Ala Leu Phe Phe Glu Gln Leu Ser Lys Arg Asn 
    50                  55                  60                  


Arg 
65  


<210> 1412
<211> 394
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<400> 1412
Met Asp Ser Gln Gly Arg Lys Val Val Val Cys Asp Asn Gly Xaa Gly 
1               5                   10                  15      


Phe Val Lys Cys Gly Tyr Ala Gly Ser Asn Phe Pro Glu His Ile Phe 
            20                  25                  30          


Pro Ala Leu Val Gly Arg Pro Ile Ile Arg Ser Xaa Xaa Lys Val Gly 
        35                  40                  45              


Asn Ile Glu Ile Lys Asp Leu Met Val Gly Asp Glu Ala Ser Glu Leu 
    50                  55                  60                  


Arg Ser Met Leu Glu Val Asn Tyr Pro Met Glu Asn Gly Ile Val Arg 
65                  70                  75                  80  


Asn Trp Asp Asp Met Lys His Leu Trp Asp Tyr Xaa Phe Gly Pro Glu 
                85                  90                  95      


Lys Leu Asn Ile Asp Xaa Arg Asn Cys Lys Ile Leu Leu Xaa Glu Pro 
            100                 105                 110         


Pro Met Asn Pro Xaa Lys Asn Arg Glu Lys Ile Val Glu Val Met Phe 
        115                 120                 125             


Glu Xaa Tyr Gln Phe Ser Gly Val Tyr Val Ala Ile Gln Ala Val Leu 
    130                 135                 140                 


Xaa Leu Tyr Ala Gln Gly Leu Leu Xaa Gly Val Val Val Asp Ser Gly 
145                 150                 155                 160 


Asp Gly Val Xaa His Ile Cys Pro Val Tyr Glu Gly Phe Ser Leu Pro 
                165                 170                 175     


His Leu Xaa Arg Arg Leu Asp Ile Ala Gly Arg Asp Ile Xaa Arg Tyr 
            180                 185                 190         


Leu Ile Lys Leu Leu Leu Leu Arg Gly Tyr Ala Phe Asn His Ser Ala 
        195                 200                 205             


Asp Phe Glu Xaa Val Arg Met Ile Lys Glu Lys Leu Cys Tyr Val Gly 
    210                 215                 220                 


Tyr Asn Ile Glu Gln Glu Gln Lys Leu Ala Leu Glu Xaa Xaa Val Leu 
225                 230                 235                 240 


Val Glu Ser Tyr Xaa Leu Pro Asp Gly Arg Ile Ile Lys Val Gly Gly 
                245                 250                 255     


Glu Arg Phe Glu Ala Pro Glu Ala Leu Phe Gln Pro His Leu Ile Asn 
            260                 265                 270         


Val Glu Gly Val Gly Val Ala Glu Leu Leu Phe Asn Xaa Ile Gln Ala 
        275                 280                 285             


Ala Asp Ile Asp Xaa Arg Ser Glu Phe Tyr Lys His Ile Val Leu Ser 
    290                 295                 300                 


Gly Gly Ser Xaa Met Tyr Pro Gly Leu Pro Ser Arg Leu Glu Arg Glu 
305                 310                 315                 320 


Leu Lys Gln Leu Tyr Leu Glu Arg Val Leu Lys Gly Asp Val Glu Lys 
                325                 330                 335     


Leu Ser Lys Phe Lys Ile Arg Ile Glu Asp Pro Pro Arg Arg Lys His 
            340                 345                 350         


Met Val Phe Leu Gly Gly Ala Val Leu Ala Asp Ile Met Lys Asp Lys 
        355                 360                 365             


Asp Asn Phe Trp Met Xaa Arg Gln Glu Tyr Gln Glu Lys Gly Val Arg 
    370                 375                 380                 


Val Leu Glu Lys Leu Gly Val Xaa Val Arg 
385                 390                 


<210> 1413
<211> 399
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<400> 1413
Met Asp Ser Gln Gly Arg Lys Val Val Val Cys Asp Asn Gly Xaa Gly 
1               5                   10                  15      


Phe Val Lys Cys Gly Tyr Ala Gly Ser Asn Phe Pro Glu His Ile Phe 
            20                  25                  30          


Pro Ala Leu Val Gly Arg Pro Ile Ile Arg Ser Xaa Xaa Lys Val Gly 
        35                  40                  45              


Asn Ile Glu Ile Lys Asn Asn Lys Lys Met Asp Leu Met Val Gly Asp 
    50                  55                  60                  


Glu Ala Ser Glu Leu Arg Ser Met Leu Glu Val Asn Tyr Pro Met Glu 
65                  70                  75                  80  


Asn Gly Ile Val Arg Asn Trp Asp Asp Met Lys His Leu Trp Asp Tyr 
                85                  90                  95      


Xaa Phe Gly Pro Glu Lys Leu Asn Ile Asp Xaa Arg Asn Cys Lys Ile 
            100                 105                 110         


Leu Leu Xaa Glu Pro Pro Met Asn Pro Xaa Lys Asn Arg Glu Lys Ile 
        115                 120                 125             


Val Glu Val Met Phe Glu Xaa Tyr Gln Phe Ser Gly Val Tyr Val Ala 
    130                 135                 140                 


Ile Gln Ala Val Leu Xaa Leu Tyr Ala Gln Gly Leu Leu Xaa Gly Val 
145                 150                 155                 160 


Val Val Asp Ser Gly Asp Gly Val Xaa His Ile Cys Pro Val Tyr Glu 
                165                 170                 175     


Gly Phe Ser Leu Pro His Leu Xaa Arg Arg Leu Asp Ile Ala Gly Arg 
            180                 185                 190         


Asp Ile Xaa Arg Tyr Leu Ile Lys Leu Leu Leu Leu Arg Gly Tyr Ala 
        195                 200                 205             


Phe Asn His Ser Ala Asp Phe Glu Xaa Val Arg Met Ile Lys Glu Lys 
    210                 215                 220                 


Leu Cys Tyr Val Gly Tyr Asn Ile Glu Gln Glu Gln Lys Leu Ala Leu 
225                 230                 235                 240 


Glu Xaa Xaa Val Leu Val Glu Ser Tyr Xaa Leu Pro Asp Gly Arg Ile 
                245                 250                 255     


Ile Lys Val Gly Gly Glu Arg Phe Glu Ala Pro Glu Ala Leu Phe Gln 
            260                 265                 270         


Pro His Leu Ile Asn Val Glu Gly Val Gly Val Ala Glu Leu Leu Phe 
        275                 280                 285             


Asn Xaa Ile Gln Ala Ala Asp Ile Asp Xaa Arg Ser Glu Phe Tyr Lys 
    290                 295                 300                 


His Ile Val Leu Ser Gly Gly Ser Xaa Met Tyr Pro Gly Leu Pro Ser 
305                 310                 315                 320 


Arg Leu Glu Arg Glu Leu Lys Gln Leu Tyr Leu Glu Arg Val Leu Lys 
                325                 330                 335     


Gly Asp Val Glu Lys Leu Ser Lys Phe Lys Ile Arg Ile Glu Asp Pro 
            340                 345                 350         


Pro Arg Arg Lys His Met Val Phe Leu Gly Gly Ala Val Leu Ala Asp 
        355                 360                 365             


Ile Met Lys Asp Lys Asp Asn Phe Trp Met Xaa Arg Gln Glu Tyr Gln 
    370                 375                 380                 


Glu Lys Gly Val Arg Val Leu Glu Lys Leu Gly Val Xaa Val Arg 
385                 390                 395                 


<210> 1414
<211> 339
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<400> 1414
Met Val Gly Asp Glu Ala Ser Glu Leu Arg Ser Met Leu Glu Val Asn 
1               5                   10                  15      


Tyr Pro Met Glu Asn Gly Ile Val Arg Asn Trp Asp Asp Met Lys His 
            20                  25                  30          


Leu Trp Asp Tyr Xaa Phe Gly Pro Glu Lys Leu Asn Ile Asp Xaa Arg 
        35                  40                  45              


Asn Cys Lys Ile Leu Leu Xaa Glu Pro Pro Met Asn Pro Xaa Lys Asn 
    50                  55                  60                  


Arg Glu Lys Ile Val Glu Val Met Phe Glu Xaa Tyr Gln Phe Ser Gly 
65                  70                  75                  80  


Val Tyr Val Ala Ile Gln Ala Val Leu Xaa Leu Tyr Ala Gln Gly Leu 
                85                  90                  95      


Leu Xaa Gly Val Val Val Asp Ser Gly Asp Gly Val Xaa His Ile Cys 
            100                 105                 110         


Pro Val Tyr Glu Gly Phe Ser Leu Pro His Leu Xaa Arg Arg Leu Asp 
        115                 120                 125             


Ile Ala Gly Arg Asp Ile Xaa Arg Tyr Leu Ile Lys Leu Leu Leu Leu 
    130                 135                 140                 


Arg Gly Tyr Ala Phe Asn His Ser Ala Asp Phe Glu Xaa Val Arg Met 
145                 150                 155                 160 


Ile Lys Glu Lys Leu Cys Tyr Val Gly Tyr Asn Ile Glu Gln Glu Gln 
                165                 170                 175     


Lys Leu Ala Leu Glu Xaa Xaa Val Leu Val Glu Ser Tyr Xaa Leu Pro 
            180                 185                 190         


Asp Gly Arg Ile Ile Lys Val Gly Gly Glu Arg Phe Glu Ala Pro Glu 
        195                 200                 205             


Ala Leu Phe Gln Pro His Leu Ile Asn Val Glu Gly Val Gly Val Ala 
    210                 215                 220                 


Glu Leu Leu Phe Asn Xaa Ile Gln Ala Ala Asp Ile Asp Xaa Arg Ser 
225                 230                 235                 240 


Glu Phe Tyr Lys His Ile Val Leu Ser Gly Gly Ser Xaa Met Tyr Pro 
                245                 250                 255     


Gly Leu Pro Ser Arg Leu Glu Arg Glu Leu Lys Gln Leu Tyr Leu Glu 
            260                 265                 270         


Arg Val Leu Lys Gly Asp Val Glu Lys Leu Ser Lys Phe Lys Ile Arg 
        275                 280                 285             


Ile Glu Asp Pro Pro Arg Arg Lys His Met Val Phe Leu Gly Gly Ala 
    290                 295                 300                 


Val Leu Ala Asp Ile Met Lys Asp Lys Asp Asn Phe Trp Met Xaa Arg 
305                 310                 315                 320 


Gln Glu Tyr Gln Glu Lys Gly Val Arg Val Leu Glu Lys Leu Gly Val 
                325                 330                 335     


Xaa Val Arg 
            


<210> 1415
<211> 418
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<400> 1415
Met Ala Gly Arg Leu Pro Ala Cys Val Val Asp Cys Gly Xaa Gly Tyr 
1               5                   10                  15      


Xaa Lys Leu Gly Tyr Ala Gly Asn Xaa Glu Pro Gln Phe Ile Ile Pro 
            20                  25                  30          


Ser Cys Ile Ala Ile Lys Glu Ser Ala Lys Val Gly Asp Gln Ala Gln 
        35                  40                  45              


Arg Arg Val Met Lys Gly Val Asp Asp Leu Asp Phe Phe Ile Gly Asp 
    50                  55                  60                  


Glu Ala Ile Glu Lys Pro Xaa Tyr Ala Xaa Lys Trp Pro Ile Arg His 
65                  70                  75                  80  


Gly Ile Val Glu Asp Trp Asp Leu Met Glu Arg Phe Met Glu Gln Val 
                85                  90                  95      


Ile Phe Lys Tyr Leu Arg Ala Glu Pro Glu Asp His Tyr Phe Leu Leu 
            100                 105                 110         


Xaa Glu Pro Pro Leu Asn Xaa Pro Glu Asn Arg Glu Tyr Xaa Ala Glu 
        115                 120                 125             


Ile Met Phe Glu Ser Phe Asn Val Pro Gly Leu Tyr Ile Ala Val Gln 
    130                 135                 140                 


Ala Val Leu Ala Leu Ala Ala Ser Trp Xaa Ser Arg Gln Val Gly Glu 
145                 150                 155                 160 


Arg Xaa Leu Xaa Gly Xaa Val Ile Asp Ser Gly Asp Gly Val Xaa His 
                165                 170                 175     


Val Ile Pro Val Ala Glu Gly Tyr Val Ile Gly Ser Cys Ile Lys His 
            180                 185                 190         


Ile Pro Ile Ala Gly Arg Asp Ile Xaa Tyr Phe Ile Gln Gln Leu Leu 
        195                 200                 205             


Arg Asp Arg Glu Val Gly Ile Pro Pro Glu Gln Ser Leu Glu Xaa Ala 
    210                 215                 220                 


Lys Ala Val Lys Glu Arg Tyr Ser Tyr Val Cys Pro Asp Leu Val Lys 
225                 230                 235                 240 


Glu Phe Asn Lys Tyr Asp Xaa Asp Gly Ser Lys Trp Ile Lys Gln Tyr 
                245                 250                 255     


Xaa Gly Ile Asn Ala Ile Ser Lys Lys Glu Phe Ser Ile Asp Val Gly 
            260                 265                 270         


Tyr Glu Arg Phe Leu Gly Pro Glu Ile Phe Phe His Pro Glu Phe Ala 
        275                 280                 285             


Asn Pro Asp Phe Xaa Gln Pro Ile Ser Glu Val Val Asp Glu Val Ile 
    290                 295                 300                 


Gln Asn Cys Pro Ile Asp Val Arg Arg Pro Leu Tyr Lys Asn Ile Val 
305                 310                 315                 320 


Leu Ser Gly Gly Ser Xaa Met Phe Arg Asp Phe Gly Arg Arg Leu Gln 
                325                 330                 335     


Arg Asp Leu Lys Arg Xaa Val Asp Ala Arg Leu Lys Leu Ser Glu Glu 
            340                 345                 350         


Leu Ser Gly Gly Arg Leu Lys Pro Lys Pro Ile Asp Val Gln Val Ile 
        355                 360                 365             


Xaa His His Met Gln Arg Tyr Ala Val Trp Phe Gly Gly Ser Met Leu 
    370                 375                 380                 


Ala Ser Xaa Pro Glu Phe Tyr Gln Val Cys His Xaa Lys Lys Asp Tyr 
385                 390                 395                 400 


Glu Glu Ile Gly Pro Ser Ile Cys Arg His Asn Pro Val Phe Gly Val 
                405                 410                 415     


Met Ser 
        


<210> 1416
<211> 41
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<400> 1416
Met Ala Gly Arg Leu Pro Ala Cys Val Val Asp Cys Gly Xaa Gly Tyr 
1               5                   10                  15      


Xaa Lys Leu Gly Tyr Ala Gly Asn Xaa Glu Pro Gln Phe Ile Ile Pro 
            20                  25                  30          


Ser Leu Ala Asn Pro Pro Trp Tyr Ser 
        35                  40      


<210> 1417
<211> 34
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<400> 1417
Met Ala Gly Arg Leu Pro Ala Cys Val Val Asp Cys Gly Xaa Gly Tyr 
1               5                   10                  15      


Xaa Lys Leu Gly Tyr Ala Gly Asn Xaa Glu Pro Gln Phe Ile Ile Pro 
            20                  25                  30          


Ser Tyr 
        


<210> 1418
<211> 84
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<400> 1418
Met Lys Gly Val Asp Asp Leu Asp Phe Phe Ile Gly Asp Glu Ala Ile 
1               5                   10                  15      


Glu Lys Pro Xaa Tyr Ala Xaa Lys Trp Pro Ile Arg His Gly Ile Val 
            20                  25                  30          


Glu Asp Trp Asp Leu Met Glu Arg Phe Met Glu Gln Val Ile Phe Lys 
        35                  40                  45              


Tyr Leu Arg Ala Glu Pro Glu Asp His Tyr Phe Leu Leu Xaa Glu Pro 
    50                  55                  60                  


Pro Leu Asn Xaa Pro Glu Asn Arg Glu Tyr Xaa Ala Glu Ile Met Phe 
65                  70                  75                  80  


Glu Ser Phe Asn 
                


<210> 1419
<211> 367
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<400> 1419
Met Lys Gly Val Asp Asp Leu Asp Phe Phe Ile Gly Asp Glu Ala Ile 
1               5                   10                  15      


Glu Lys Pro Xaa Tyr Ala Xaa Lys Trp Pro Ile Arg His Gly Ile Val 
            20                  25                  30          


Glu Asp Trp Asp Leu Met Glu Arg Phe Met Glu Gln Val Ile Phe Lys 
        35                  40                  45              


Tyr Leu Arg Ala Glu Pro Glu Asp His Tyr Phe Leu Leu Xaa Glu Pro 
    50                  55                  60                  


Pro Leu Asn Xaa Pro Glu Asn Arg Glu Tyr Xaa Ala Glu Ile Met Phe 
65                  70                  75                  80  


Glu Ser Phe Asn Val Pro Gly Leu Tyr Ile Ala Val Gln Ala Val Leu 
                85                  90                  95      


Ala Leu Ala Ala Ser Trp Xaa Ser Arg Gln Val Gly Glu Arg Xaa Leu 
            100                 105                 110         


Xaa Gly Xaa Val Ile Asp Ser Gly Asp Gly Val Xaa His Val Ile Pro 
        115                 120                 125             


Val Ala Glu Gly Tyr Val Ile Gly Ser Cys Ile Lys His Ile Pro Ile 
    130                 135                 140                 


Ala Gly Arg Asp Ile Xaa Tyr Phe Ile Gln Gln Leu Leu Arg Asp Arg 
145                 150                 155                 160 


Glu Val Gly Ile Pro Pro Glu Gln Ser Leu Glu Xaa Ala Lys Ala Val 
                165                 170                 175     


Lys Glu Arg Tyr Ser Tyr Val Cys Pro Asp Leu Val Lys Glu Phe Asn 
            180                 185                 190         


Lys Tyr Asp Xaa Asp Gly Ser Lys Trp Ile Lys Gln Tyr Xaa Gly Ile 
        195                 200                 205             


Asn Ala Ile Ser Lys Lys Glu Phe Ser Ile Asp Val Gly Tyr Glu Arg 
    210                 215                 220                 


Phe Leu Gly Pro Glu Ile Phe Phe His Pro Glu Phe Ala Asn Pro Asp 
225                 230                 235                 240 


Phe Xaa Gln Pro Ile Ser Glu Val Val Asp Glu Val Ile Gln Asn Cys 
                245                 250                 255     


Pro Ile Asp Val Arg Arg Pro Leu Tyr Lys Asn Ile Val Leu Ser Gly 
            260                 265                 270         


Gly Ser Xaa Met Phe Arg Asp Phe Gly Arg Arg Leu Gln Arg Asp Leu 
        275                 280                 285             


Lys Arg Xaa Val Asp Ala Arg Leu Lys Leu Ser Glu Glu Leu Ser Gly 
    290                 295                 300                 


Gly Arg Leu Lys Pro Lys Pro Ile Asp Val Gln Val Ile Xaa His His 
305                 310                 315                 320 


Met Gln Arg Tyr Ala Val Trp Phe Gly Gly Ser Met Leu Ala Ser Xaa 
                325                 330                 335     


Pro Glu Phe Tyr Gln Val Cys His Xaa Lys Lys Asp Tyr Glu Glu Ile 
            340                 345                 350         


Gly Pro Ser Ile Cys Arg His Asn Pro Val Phe Gly Val Met Ser 
        355                 360                 365         


<210> 1420
<211> 376
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<400> 1420
Met Xaa Xaa Leu Val Leu Asp Asn Gly Ala Tyr Asn Ala Lys Ile Gly 
1               5                   10                  15      


Tyr Ser His Glu Asn Val Ser Val Ile Pro Asn Cys Gln Phe Arg Ser 
            20                  25                  30          


Lys Xaa Ala Arg Leu Lys Xaa Phe Xaa Ala Asn Gln Ile Asp Glu Ile 
        35                  40                  45              


Lys Asp Pro Ser Gly Leu Phe Tyr Ile Leu Pro Phe Gln Lys Gly Tyr 
    50                  55                  60                  


Leu Val Asn Trp Asp Val Gln Arg Gln Val Trp Asp Tyr Leu Phe Gly 
65                  70                  75                  80  


Lys Glu Met Tyr Gln Val Asp Phe Leu Asp Xaa Asn Ile Ile Ile Xaa 
                85                  90                  95      


Glu Pro Tyr Phe Asn Phe Xaa Ser Ile Gln Glu Ser Met Asn Glu Ile 
            100                 105                 110         


Leu Phe Glu Glu Tyr Gln Phe Gln Ala Val Leu Arg Val Asn Ala Gly 
        115                 120                 125             


Ala Leu Ser Ala His Arg Tyr Phe Arg Asp Asn Pro Ser Glu Leu Cys 
    130                 135                 140                 


Cys Ile Ile Val Asp Ser Gly Tyr Ser Phe Xaa His Ile Val Pro Tyr 
145                 150                 155                 160 


Cys Arg Ser Lys Lys Lys Lys Glu Ala Ile Ile Arg Ile Asn Val Gly 
                165                 170                 175     


Gly Lys Leu Leu Xaa Asn His Leu Lys Glu Ile Ile Ser Tyr Arg Gln 
            180                 185                 190         


Leu His Val Met Asp Glu Xaa His Val Ile Asn Gln Val Lys Glu Asp 
        195                 200                 205             


Val Cys Tyr Val Ser Gln Asp Phe Tyr Arg Asp Met Asp Ile Ala Lys 
    210                 215                 220                 


Leu Lys Gly Glu Glu Asn Xaa Val Met Ile Asp Tyr Val Leu Pro Asp 
225                 230                 235                 240 


Phe Ser Xaa Ile Lys Lys Gly Phe Cys Lys Pro Arg Glu Glu Met Val 
                245                 250                 255     


Leu Ser Gly Lys Tyr Lys Ser Gly Glu Gln Ile Leu Arg Leu Ala Asn 
            260                 265                 270         


Glu Arg Phe Ala Val Pro Glu Ile Leu Phe Asn Pro Ser Asp Ile Gly 
        275                 280                 285             


Ile Gln Glu Met Gly Ile Pro Glu Ala Ile Val Tyr Ser Ile Gln Asn 
    290                 295                 300                 


Leu Pro Glu Gly Phe Arg Asp Arg Val Tyr Ser Glu Val Arg Cys Leu 
305                 310                 315                 320 


Xaa Pro Xaa Asp Tyr Asp Val Ser Val Val Leu Pro Glu Asn Pro Ile 
                325                 330                 335     


Xaa Tyr Ala Trp Glu Gly Gly Lys Leu Ile Ser Glu Asn Asp Asp Phe 
            340                 345                 350         


Glu Asp Met Val Val Xaa Arg Glu Asp Tyr Glu Glu Asn Gly His Ser 
        355                 360                 365             


Val Cys Glu Glu Lys Phe Asp Ile 
    370                 375     


<210> 1421
<211> 396
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<400> 1421
Met Xaa Xaa Leu Val Leu Asp Asn Gly Ala Tyr Asn Ala Lys Ile Gly 
1               5                   10                  15      


Tyr Ser His Glu Asn Val Ser Val Ile Pro Asn Cys Gln Phe Arg Ser 
            20                  25                  30          


Lys Xaa Ala Arg Leu Lys Xaa Phe Xaa Ala Asn Gln Ile Asp Glu Ile 
        35                  40                  45              


Lys Asp Pro Ser Gly Leu Phe Tyr Ile Leu Pro Phe Gln Lys Gly Tyr 
    50                  55                  60                  


Leu Val Asn Trp Asp Val Gln Arg Gln Val Trp Asp Tyr Leu Phe Gly 
65                  70                  75                  80  


Lys Glu Met Tyr Gln Val Asp Phe Leu Asp Xaa Asn Ile Ile Ile Xaa 
                85                  90                  95      


Glu Pro Tyr Phe Asn Phe Xaa Ser Ile Gln Glu Ser Met Asn Glu Ile 
            100                 105                 110         


Leu Phe Glu Glu Tyr Gln Phe Gln Ala Val Leu Arg Val Asn Ala Gly 
        115                 120                 125             


Ala Leu Ser Ala His Arg Tyr Phe Arg Asp Asn Pro Ser Glu Leu Cys 
    130                 135                 140                 


Cys Ile Ile Val Asp Ser Gly Tyr Ser Phe Xaa His Ile Val Pro Tyr 
145                 150                 155                 160 


Cys Arg Ser Lys Lys Lys Lys Glu Ala Ile Ile Arg Ile Asn Val Gly 
                165                 170                 175     


Gly Lys Leu Leu Xaa Asn His Leu Lys Glu Ile Ile Ser Tyr Arg Gln 
            180                 185                 190         


Leu His Val Met Asp Glu Xaa His Val Ile Asn Gln Val Lys Glu Asp 
        195                 200                 205             


Val Cys Tyr Val Ser Gln Asp Phe Tyr Arg Asp Met Asp Ile Ala Lys 
    210                 215                 220                 


Leu Lys Gly Glu Glu Asn Xaa Val Met Ile Asp Tyr Val Leu Pro Asp 
225                 230                 235                 240 


Phe Ser Xaa Ile Lys Lys Gly Phe Cys Lys Pro Arg Glu Glu Met Val 
                245                 250                 255     


Leu Ser Gly Lys Tyr Lys Ser Gly Glu Gln Ile Leu Arg Leu Ala Asn 
            260                 265                 270         


Glu Arg Phe Ala Val Pro Glu Ile Leu Phe Asn Pro Ser Asp Ile Gly 
        275                 280                 285             


Ile Gln Glu Met Gly Ile Pro Glu Ala Ile Val Tyr Ser Ile Gln Asn 
    290                 295                 300                 


Leu Pro Glu Glu Met Gln Pro His Phe Phe Lys Asn Ile Val Leu Xaa 
305                 310                 315                 320 


Gly Gly Asn Ser Leu Phe Pro Gly Phe Arg Asp Arg Val Tyr Ser Glu 
                325                 330                 335     


Val Arg Cys Leu Xaa Pro Xaa Asp Tyr Asp Val Ser Val Val Leu Pro 
            340                 345                 350         


Glu Asn Pro Ile Xaa Tyr Ala Trp Glu Gly Gly Lys Leu Ile Ser Glu 
        355                 360                 365             


Asn Asp Asp Phe Glu Asp Met Val Val Xaa Arg Glu Asp Tyr Glu Glu 
    370                 375                 380                 


Asn Gly His Ser Val Cys Glu Glu Lys Phe Asp Ile 
385                 390                 395     


<210> 1422
<211> 127
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 1422
Met Xaa Xaa Leu Val Leu Asp Asn Gly Ala Tyr Asn Ala Lys Ile Gly 
1               5                   10                  15      


Tyr Ser His Glu Asn Val Ser Val Ile Pro Asn Cys Gln Phe Arg Ser 
            20                  25                  30          


Lys Xaa Ala Arg Leu Lys Xaa Phe Xaa Ala Asn Gln Ile Asp Glu Ile 
        35                  40                  45              


Lys Asp Pro Ser Gly Leu Phe Tyr Ile Leu Pro Phe Gln Lys Gly Tyr 
    50                  55                  60                  


Leu Val Asn Trp Asp Val Gln Arg Gln Val Trp Asp Tyr Leu Phe Gly 
65                  70                  75                  80  


Lys Glu Met Tyr Gln Val Asp Phe Leu Asp Xaa Asn Ile Ile Ile Xaa 
                85                  90                  95      


Glu Pro Tyr Phe Asn Phe Xaa Ser Ile Gln Glu Ser Met Asn Glu Ile 
            100                 105                 110         


Leu Phe Glu Glu Tyr Gln Phe Gln Ala Val Leu Arg Val Asn Gly 
        115                 120                 125         


<210> 1423
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 1423
Met Xaa Xaa Leu Val Leu Asp Asn Gly Ala Tyr Asn Ala Lys Ile Gly 
1               5                   10                  15      


Tyr Ser His Glu Asn Val Ser Val Ile Pro Asn Cys Gln Phe Arg Ser 
            20                  25                  30          


Lys Xaa Ala Arg Leu Lys Xaa Phe Xaa Ala Asn Gln Ile Asp Glu Ile 
        35                  40                  45              


Lys Asp Pro Ser Gly Leu Phe Tyr Ile Leu Pro Phe Gln Lys Gly Tyr 
    50                  55                  60                  


Leu Val Asn Trp Asp Val Gln Arg Gln Val Trp Asp Tyr Leu Phe Gly 
65                  70                  75                  80  


Lys Glu Met Tyr Gln Val Asp Phe Leu Asp Xaa Asn Ile Ile Ile Xaa 
                85                  90                  95      


Glu Pro Tyr Phe Asn Phe Xaa Ser Ile Gln Glu Ser Met Asn Glu Ile 
            100                 105                 110         


Leu Phe Glu Glu Tyr Gln Phe Gln Ala Val Leu Arg Val Asn Gly Ser 
        115                 120                 125             


Cys Ser Val Ala Gln Ala Arg Val Trp Trp His Lys His Gly Ser Leu 
    130                 135                 140                 


<210> 1424
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<400> 1424
Met Xaa Xaa Leu Val Leu Asp Asn Gly Ala Tyr Asn Ala Lys Ile Gly 
1               5                   10                  15      


Tyr Ser His Glu Asn Val Ser Val Ile Pro Asn Cys Gln Phe Arg Ser 
            20                  25                  30          


Lys Xaa Ala Arg Leu Lys Xaa Phe Xaa Ala Asn Gln Ile Asp Glu Ile 
        35                  40                  45              


Lys Asp Pro Ser Gly Leu Phe Tyr Ile Leu Pro Phe Gln Lys Gly Tyr 
    50                  55                  60                  


Leu Val Asn Trp Asp Val Gln Arg Gln Val Trp Asp Tyr Leu Phe Gly 
65                  70                  75                  80  


Lys Glu Met Tyr Gln Val Xaa Asn 
                85              


<210> 1425
<211> 192
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<400> 1425
Met Tyr Gln Gly Pro Ser Arg Val Leu Lys Glu Ala Pro Gly Ala Glu 
1               5                   10                  15      


Ala Tyr Gly Tyr Glu Cys Leu Gly Gly Leu His Arg Xaa Ser Xaa Gly 
            20                  25                  30          


Cys Trp Gly Val Ile Pro Asn Cys Gln Phe Arg Ser Lys Xaa Ala Arg 
        35                  40                  45              


Leu Lys Xaa Phe Xaa Ala Asn Gln Ile Asp Glu Ile Lys Asp Pro Ser 
    50                  55                  60                  


Gly Leu Phe Tyr Ile Leu Pro Phe Gln Lys Gly Tyr Leu Val Asn Trp 
65                  70                  75                  80  


Asp Val Gln Arg Gln Val Trp Asp Tyr Leu Phe Gly Lys Glu Met Tyr 
                85                  90                  95      


Gln Val Asp Phe Leu Asp Xaa Asn Ile Ile Ile Xaa Glu Pro Tyr Phe 
            100                 105                 110         


Asn Phe Xaa Ser Ile Gln Glu Ser Met Asn Glu Ile Leu Phe Glu Glu 
        115                 120                 125             


Tyr Gln Phe Gln Ala Val Leu Arg Val Asn Ala Gly Ala Leu Ser Ala 
    130                 135                 140                 


His Arg Tyr Phe Arg Asp Asn Pro Ser Glu Leu Cys Cys Ile Ile Val 
145                 150                 155                 160 


Asp Ser Gly Tyr Ser Phe Xaa His Ile Val Pro Tyr Cys Arg Ser Lys 
                165                 170                 175     


Lys Lys Lys Glu Ala Ile Ile Arg Ile Asn Val Gly Gly Lys Leu Leu 
            180                 185                 190         


<210> 1426
<211> 314
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<400> 1426
Met Tyr Gln Val Asp Phe Leu Asp Xaa Asn Ile Ile Ile Xaa Glu Pro 
1               5                   10                  15      


Tyr Phe Asn Phe Xaa Ser Ile Gln Glu Ser Met Asn Glu Ile Leu Phe 
            20                  25                  30          


Glu Glu Tyr Gln Phe Gln Ala Val Leu Arg Val Asn Ala Gly Ala Leu 
        35                  40                  45              


Ser Ala His Arg Tyr Phe Arg Asp Asn Pro Ser Glu Leu Cys Cys Ile 
    50                  55                  60                  


Ile Val Asp Ser Gly Tyr Ser Phe Xaa His Ile Val Pro Tyr Cys Arg 
65                  70                  75                  80  


Ser Lys Lys Lys Lys Glu Ala Ile Ile Arg Ile Asn Val Gly Gly Lys 
                85                  90                  95      


Leu Leu Xaa Asn His Leu Lys Glu Ile Ile Ser Tyr Arg Gln Leu His 
            100                 105                 110         


Val Met Asp Glu Xaa His Val Ile Asn Gln Val Lys Glu Asp Val Cys 
        115                 120                 125             


Tyr Val Ser Gln Asp Phe Tyr Arg Asp Met Asp Ile Ala Lys Leu Lys 
    130                 135                 140                 


Gly Glu Glu Asn Xaa Val Met Ile Asp Tyr Val Leu Pro Asp Phe Ser 
145                 150                 155                 160 


Xaa Ile Lys Lys Gly Phe Cys Lys Pro Arg Glu Glu Met Val Leu Ser 
                165                 170                 175     


Gly Lys Tyr Lys Ser Gly Glu Gln Ile Leu Arg Leu Ala Asn Glu Arg 
            180                 185                 190         


Phe Ala Val Pro Glu Ile Leu Phe Asn Pro Ser Asp Ile Gly Ile Gln 
        195                 200                 205             


Glu Met Gly Ile Pro Glu Ala Ile Val Tyr Ser Ile Gln Asn Leu Pro 
    210                 215                 220                 


Glu Glu Met Gln Pro His Phe Phe Lys Asn Ile Val Leu Xaa Gly Gly 
225                 230                 235                 240 


Asn Ser Leu Phe Pro Gly Phe Arg Asp Arg Val Tyr Ser Glu Val Arg 
                245                 250                 255     


Cys Leu Xaa Pro Xaa Asp Tyr Asp Val Ser Val Val Leu Pro Glu Asn 
            260                 265                 270         


Pro Ile Xaa Tyr Ala Trp Glu Gly Gly Lys Leu Ile Ser Glu Asn Asp 
        275                 280                 285             


Asp Phe Glu Asp Met Val Val Xaa Arg Glu Asp Tyr Glu Glu Asn Gly 
    290                 295                 300                 


His Ser Val Cys Glu Glu Lys Phe Asp Ile 
305                 310                 


<210> 1427
<211> 294
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<400> 1427
Met Tyr Gln Val Asp Phe Leu Asp Xaa Asn Ile Ile Ile Xaa Glu Pro 
1               5                   10                  15      


Tyr Phe Asn Phe Xaa Ser Ile Gln Glu Ser Met Asn Glu Ile Leu Phe 
            20                  25                  30          


Glu Glu Tyr Gln Phe Gln Ala Val Leu Arg Val Asn Ala Gly Ala Leu 
        35                  40                  45              


Ser Ala His Arg Tyr Phe Arg Asp Asn Pro Ser Glu Leu Cys Cys Ile 
    50                  55                  60                  


Ile Val Asp Ser Gly Tyr Ser Phe Xaa His Ile Val Pro Tyr Cys Arg 
65                  70                  75                  80  


Ser Lys Lys Lys Lys Glu Ala Ile Ile Arg Ile Asn Val Gly Gly Lys 
                85                  90                  95      


Leu Leu Xaa Asn His Leu Lys Glu Ile Ile Ser Tyr Arg Gln Leu His 
            100                 105                 110         


Val Met Asp Glu Xaa His Val Ile Asn Gln Val Lys Glu Asp Val Cys 
        115                 120                 125             


Tyr Val Ser Gln Asp Phe Tyr Arg Asp Met Asp Ile Ala Lys Leu Lys 
    130                 135                 140                 


Gly Glu Glu Asn Xaa Val Met Ile Asp Tyr Val Leu Pro Asp Phe Ser 
145                 150                 155                 160 


Xaa Ile Lys Lys Gly Phe Cys Lys Pro Arg Glu Glu Met Val Leu Ser 
                165                 170                 175     


Gly Lys Tyr Lys Ser Gly Glu Gln Ile Leu Arg Leu Ala Asn Glu Arg 
            180                 185                 190         


Phe Ala Val Pro Glu Ile Leu Phe Asn Pro Ser Asp Ile Gly Ile Gln 
        195                 200                 205             


Glu Met Gly Ile Pro Glu Ala Ile Val Tyr Ser Ile Gln Asn Leu Pro 
    210                 215                 220                 


Glu Gly Phe Arg Asp Arg Val Tyr Ser Glu Val Arg Cys Leu Xaa Pro 
225                 230                 235                 240 


Xaa Asp Tyr Asp Val Ser Val Val Leu Pro Glu Asn Pro Ile Xaa Tyr 
                245                 250                 255     


Ala Trp Glu Gly Gly Lys Leu Ile Ser Glu Asn Asp Asp Phe Glu Asp 
            260                 265                 270         


Met Val Val Xaa Arg Glu Asp Tyr Glu Glu Asn Gly His Ser Val Cys 
        275                 280                 285             


Glu Glu Lys Phe Asp Ile 
    290                 


<210> 1428
<211> 624
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(598)
<223> Selenocysteine

<400> 1428
Met Xaa Gln Ala Glu Lys Gly Asp Xaa Glu Asn Gly Lys Glu Lys Gly 
1               5                   10                  15      


Gly Glu Lys Glu Lys Glu Gln Arg Gly Val Lys Arg Pro Ile Val Pro 
            20                  25                  30          


Ala Leu Val Pro Glu Ser Leu Gln Glu Gln Ile Gln Ser Asn Phe Ile 
        35                  40                  45              


Ile Val Ile His Pro Gly Ser Xaa Xaa Leu Arg Ile Gly Arg Ala Xaa 
    50                  55                  60                  


Asp Xaa Leu Pro Ala Ser Ile Pro His Val Ile Ala Arg Arg His Lys 
65                  70                  75                  80  


Gln Gln Gly Gln Pro Leu Tyr Lys Asp Ser Trp Leu Leu Arg Glu Gly 
                85                  90                  95      


Leu Asn Lys Pro Glu Ser Asn Glu Gln Arg Gln Asn Gly Leu Lys Met 
            100                 105                 110         


Val Asp Gln Ala Ile Trp Ser Lys Lys Met Ser Asn Gly Xaa Arg Arg 
        115                 120                 125             


Ile Pro Val Ser Pro Glu Gln Ala Arg Ser Tyr Asn Lys Gln Met Arg 
    130                 135                 140                 


Pro Ala Ile Leu Asp His Cys Ser Gly Asn Lys Trp Xaa Asn Xaa Ser 
145                 150                 155                 160 


His His Pro Glu Tyr Leu Val Gly Glu Glu Ala Leu Tyr Val Asn Pro 
                165                 170                 175     


Leu Asp Cys Tyr Asn Ile His Trp Pro Ile Arg Arg Gly Gln Leu Asn 
            180                 185                 190         


Ile His Pro Gly Pro Gly Gly Ser Leu Xaa Ala Val Leu Ala Asp Ile 
        195                 200                 205             


Glu Val Ile Trp Ser His Ala Ile Gln Lys Tyr Leu Glu Ile Pro Leu 
    210                 215                 220                 


Lys Asp Leu Lys Tyr Tyr Arg Cys Ile Leu Leu Ile Pro Asp Ile Tyr 
225                 230                 235                 240 


Asn Lys Gln His Val Lys Glu Leu Val Asn Met Ile Leu Met Lys Met 
                245                 250                 255     


Gly Phe Ser Gly Ile Val Val His Gln Glu Ser Val Cys Ala Xaa Tyr 
            260                 265                 270         


Gly Ser Gly Leu Ser Ser Xaa Cys Ile Val Asp Val Gly Asp Gln Lys 
        275                 280                 285             


Xaa Ser Val Cys Cys Val Glu Asp Gly Val Ser His Arg Asn Xaa Arg 
    290                 295                 300                 


Leu Cys Leu Ala Tyr Gly Gly Ser Asp Val Ser Arg Cys Phe Tyr Trp 
305                 310                 315                 320 


Leu Met Gln Arg Ala Gly Phe Pro Tyr Arg Glu Cys Gln Leu Xaa Asn 
                325                 330                 335     


Lys Met Asp Cys Leu Leu Leu Gln His Leu Lys Glu Xaa Phe Cys His 
            340                 345                 350         


Leu Asp Gln Asp Ile Ser Gly Leu Gln Asp His Glu Phe Gln Ile Arg 
        355                 360                 365             


His Pro Asp Ser Pro Ala Leu Leu Tyr Gln Phe Arg Leu Gly Asp Glu 
    370                 375                 380                 


Lys Leu Gln Ala Pro Met Ala Leu Phe Tyr Pro Ala Xaa Phe Gly Ile 
385                 390                 395                 400 


Val Gly Gln Lys Met Xaa Xaa Leu Gln His Arg Ser Gln Gly Asp Pro 
                405                 410                 415     


Glu Asp Pro His Asp Glu His Tyr Leu Leu Ala Xaa Gln Ser Lys Gln 
            420                 425                 430         


Glu Gln Ser Ala Lys Ala Xaa Ala Asp Arg Lys Ser Ala Ser Lys Pro 
        435                 440                 445             


Ile Gly Phe Glu Gly Asp Leu Arg Gly Gln Ser Ser Asp Leu Pro Glu 
    450                 455                 460                 


Arg Leu His Ser Gln Glu Val Asp Leu Gly Ser Ala Gln Gly Asp Gly 
465                 470                 475                 480 


Leu Met Ala Gly Asn Asp Ser Glu Glu Ala Leu Xaa Ala Leu Met Ser 
                485                 490                 495     


Arg Lys Xaa Ala Ile Ser Leu Phe Glu Gly Lys Ala Leu Gly Leu Asp 
            500                 505                 510         


Lys Ala Ile Leu His Ser Ile Asp Cys Cys Ser Ser Asp Asp Xaa Lys 
        515                 520                 525             


Lys Lys Met Tyr Ser Ser Ile Leu Val Val Gly Gly Gly Leu Met Phe 
    530                 535                 540                 


His Lys Ala Gln Glu Phe Leu Gln His Arg Ile Leu Asn Lys Met Pro 
545                 550                 555                 560 


Pro Ser Phe Arg Arg Ile Ile Glu Asn Val Asp Val Ile Xaa Arg Pro 
                565                 570                 575     


Lys Asp Met Asp Pro Arg Leu Ile Ala Trp Lys Gly Gly Ala Val Leu 
            580                 585                 590         


Ala Cys Leu Asp Xaa Xaa Gln Glu Leu Trp Ile Tyr Gln Arg Glu Trp 
        595                 600                 605             


Gln Arg Phe Gly Val Arg Met Leu Arg Glu Arg Ala Ala Phe Val Trp 
    610                 615                 620                 


<210> 1429
<211> 102
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<400> 1429
Met Val Asp Gln Ala Ile Trp Ser Lys Lys Met Ser Asn Gly Xaa Arg 
1               5                   10                  15      


Arg Ile Pro Val Ser Pro Glu Gln Ala Arg Ser Tyr Asn Lys Gln Met 
            20                  25                  30          


Arg Pro Ala Ile Leu Asp His Cys Ser Gly Asn Lys Trp Xaa Asn Xaa 
        35                  40                  45              


Ser His His Pro Glu Tyr Leu Val Gly Glu Glu Ala Leu Tyr Val Asn 
    50                  55                  60                  


Pro Leu Asp Cys Tyr Asn Ile His Trp Pro Ile Arg Arg Gly Gln Leu 
65                  70                  75                  80  


Asn Ile His Pro Gly Pro Gly Gly Ser Leu Xaa Ala Val Leu Ala Asp 
                85                  90                  95      


Ile Glu Val Ile Trp Ser 
            100         


<210> 1430
<211> 513
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(487)
<223> Selenocysteine

<400> 1430
Met Val Asp Gln Ala Ile Trp Ser Lys Lys Met Ser Asn Gly Xaa Arg 
1               5                   10                  15      


Arg Ile Pro Val Ser Pro Glu Gln Ala Arg Ser Tyr Asn Lys Gln Met 
            20                  25                  30          


Arg Pro Ala Ile Leu Asp His Cys Ser Gly Asn Lys Trp Xaa Asn Xaa 
        35                  40                  45              


Ser His His Pro Glu Tyr Leu Val Gly Glu Glu Ala Leu Tyr Val Asn 
    50                  55                  60                  


Pro Leu Asp Cys Tyr Asn Ile His Trp Pro Ile Arg Arg Gly Gln Leu 
65                  70                  75                  80  


Asn Ile His Pro Gly Pro Gly Gly Ser Leu Xaa Ala Val Leu Ala Asp 
                85                  90                  95      


Ile Glu Val Ile Trp Ser His Ala Ile Gln Lys Tyr Leu Glu Ile Pro 
            100                 105                 110         


Leu Lys Asp Leu Lys Tyr Tyr Arg Cys Ile Leu Leu Ile Pro Asp Ile 
        115                 120                 125             


Tyr Asn Lys Gln His Val Lys Glu Leu Val Asn Met Ile Leu Met Lys 
    130                 135                 140                 


Met Gly Phe Ser Gly Ile Val Val His Gln Glu Ser Val Cys Ala Xaa 
145                 150                 155                 160 


Tyr Gly Ser Gly Leu Ser Ser Xaa Cys Ile Val Asp Val Gly Asp Gln 
                165                 170                 175     


Lys Xaa Ser Val Cys Cys Val Glu Asp Gly Val Ser His Arg Asn Xaa 
            180                 185                 190         


Arg Leu Cys Leu Ala Tyr Gly Gly Ser Asp Val Ser Arg Cys Phe Tyr 
        195                 200                 205             


Trp Leu Met Gln Arg Ala Gly Phe Pro Tyr Arg Glu Cys Gln Leu Xaa 
    210                 215                 220                 


Asn Lys Met Asp Cys Leu Leu Leu Gln His Leu Lys Glu Xaa Phe Cys 
225                 230                 235                 240 


His Leu Asp Gln Asp Ile Ser Gly Leu Gln Asp His Glu Phe Gln Ile 
                245                 250                 255     


Arg His Pro Asp Ser Pro Ala Leu Leu Tyr Gln Phe Arg Leu Gly Asp 
            260                 265                 270         


Glu Lys Leu Gln Ala Pro Met Ala Leu Phe Tyr Pro Ala Xaa Phe Gly 
        275                 280                 285             


Ile Val Gly Gln Lys Met Xaa Xaa Leu Gln His Arg Ser Gln Gly Asp 
    290                 295                 300                 


Pro Glu Asp Pro His Asp Glu His Tyr Leu Leu Ala Xaa Gln Ser Lys 
305                 310                 315                 320 


Gln Glu Gln Ser Ala Lys Ala Xaa Ala Asp Arg Lys Ser Ala Ser Lys 
                325                 330                 335     


Pro Ile Gly Phe Glu Gly Asp Leu Arg Gly Gln Ser Ser Asp Leu Pro 
            340                 345                 350         


Glu Arg Leu His Ser Gln Glu Val Asp Leu Gly Ser Ala Gln Gly Asp 
        355                 360                 365             


Gly Leu Met Ala Gly Asn Asp Ser Glu Glu Ala Leu Xaa Ala Leu Met 
    370                 375                 380                 


Ser Arg Lys Xaa Ala Ile Ser Leu Phe Glu Gly Lys Ala Leu Gly Leu 
385                 390                 395                 400 


Asp Lys Ala Ile Leu His Ser Ile Asp Cys Cys Ser Ser Asp Asp Xaa 
                405                 410                 415     


Lys Lys Lys Met Tyr Ser Ser Ile Leu Val Val Gly Gly Gly Leu Met 
            420                 425                 430         


Phe His Lys Ala Gln Glu Phe Leu Gln His Arg Ile Leu Asn Lys Met 
        435                 440                 445             


Pro Pro Ser Phe Arg Arg Ile Ile Glu Asn Val Asp Val Ile Xaa Arg 
    450                 455                 460                 


Pro Lys Asp Met Asp Pro Arg Leu Ile Ala Trp Lys Gly Gly Ala Val 
465                 470                 475                 480 


Leu Ala Cys Leu Asp Xaa Xaa Gln Glu Leu Trp Ile Tyr Gln Arg Glu 
                485                 490                 495     


Trp Gln Arg Phe Gly Val Arg Met Leu Arg Glu Arg Ala Ala Phe Val 
            500                 505                 510         


Trp 
    


<210> 1431
<211> 378
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(352)
<223> Selenocysteine

<400> 1431
Xaa Ala Val Leu Ala Asp Ile Glu Val Ile Trp Ser His Ala Ile Gln 
1               5                   10                  15      


Lys Tyr Leu Glu Ile Pro Leu Lys Asp Leu Lys Tyr Tyr Arg Cys Ile 
            20                  25                  30          


Leu Leu Ile Pro Asp Ile Tyr Asn Lys Gln His Val Lys Glu Leu Val 
        35                  40                  45              


Asn Met Ile Leu Met Lys Met Gly Phe Ser Gly Ile Val Val His Gln 
    50                  55                  60                  


Glu Ser Val Cys Ala Xaa Tyr Gly Ser Gly Leu Ser Ser Xaa Cys Ile 
65                  70                  75                  80  


Val Asp Val Gly Asp Gln Lys Xaa Ser Val Cys Cys Val Glu Asp Gly 
                85                  90                  95      


Val Ser His Arg Asn Xaa Arg Ile Phe Ser Trp Asn Gln Asp Ile Ser 
            100                 105                 110         


Gly Leu Gln Asp His Glu Phe Gln Ile Arg His Pro Asp Ser Pro Ala 
        115                 120                 125             


Leu Leu Tyr Gln Phe Arg Leu Gly Asp Glu Lys Leu Gln Ala Pro Met 
    130                 135                 140                 


Ala Leu Phe Tyr Pro Ala Xaa Phe Gly Ile Val Gly Gln Lys Met Xaa 
145                 150                 155                 160 


Xaa Leu Gln His Arg Ser Gln Gly Asp Pro Glu Asp Pro His Asp Glu 
                165                 170                 175     


His Tyr Leu Leu Ala Xaa Gln Ser Lys Gln Glu Gln Ser Ala Lys Ala 
            180                 185                 190         


Xaa Ala Asp Arg Lys Ser Ala Ser Lys Pro Ile Gly Phe Glu Gly Asp 
        195                 200                 205             


Leu Arg Gly Gln Ser Ser Asp Leu Pro Glu Arg Leu His Ser Gln Glu 
    210                 215                 220                 


Val Asp Leu Gly Ser Ala Gln Gly Asp Gly Leu Met Ala Gly Asn Asp 
225                 230                 235                 240 


Ser Glu Glu Ala Leu Xaa Ala Leu Met Ser Arg Lys Xaa Ala Ile Ser 
                245                 250                 255     


Leu Phe Glu Gly Lys Ala Leu Gly Leu Asp Lys Ala Ile Leu His Ser 
            260                 265                 270         


Ile Asp Cys Cys Ser Ser Asp Asp Xaa Lys Lys Lys Met Tyr Ser Ser 
        275                 280                 285             


Ile Leu Val Val Gly Gly Gly Leu Met Phe His Lys Ala Gln Glu Phe 
    290                 295                 300                 


Leu Gln His Arg Ile Leu Asn Lys Met Pro Pro Ser Phe Arg Arg Ile 
305                 310                 315                 320 


Ile Glu Asn Val Asp Val Ile Xaa Arg Pro Lys Asp Met Asp Pro Arg 
                325                 330                 335     


Leu Ile Ala Trp Lys Gly Gly Ala Val Leu Ala Cys Leu Asp Xaa Xaa 
            340                 345                 350         


Gln Glu Leu Trp Ile Tyr Gln Arg Glu Trp Gln Arg Phe Gly Val Arg 
        355                 360                 365             


Met Leu Arg Glu Arg Ala Ala Phe Val Trp 
    370                 375             


<210> 1432
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1432
Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met 
            20      


<210> 1433
<211> 71
<212> PRT
<213> Homo sapiens

<400> 1433
Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu 
            20                  25                  30          


Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
        35                  40                  45              


Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His 
    50                  55                  60                  


Val Tyr Gln Lys Gly Cys Phe 
65                  70      


<210> 1434
<211> 73
<212> PRT
<213> Homo sapiens

<400> 1434
Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu 
            20                  25                  30          


Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
        35                  40                  45              


Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His 
    50                  55                  60                  


Val Tyr Gln Lys Gly Cys Phe Gln Val 
65                  70              


<210> 1435
<211> 87
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<400> 1435
Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu 
            20                  25                  30          


Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
        35                  40                  45              


Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His 
    50                  55                  60                  


Val Tyr Gln Lys Gly Cys Phe Gln Val Tyr Glu Gln Gly Lys Met Xaa 
65                  70                  75                  80  


Cys Lys Xaa Pro Pro Ser Pro 
                85          


<210> 1436
<211> 509
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<400> 1436
Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu 
            20                  25                  30          


Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
        35                  40                  45              


Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His 
    50                  55                  60                  


Val Tyr Gln Lys Gly Cys Phe Gln Val Tyr Glu Gln Gly Lys Met Xaa 
65                  70                  75                  80  


Cys Lys Xaa Pro Pro Ser Pro Gly Gln Ala Val Glu Cys Cys Gln Gly 
                85                  90                  95      


Asp Trp Cys Asn Arg Asn Ile Xaa Ala Gln Leu Pro Xaa Lys Gly Lys 
            100                 105                 110         


Ser Phe Pro Gly Xaa Gln Asn Phe His Leu Glu Val Gly Leu Ile Ile 
        115                 120                 125             


Leu Ser Val Val Phe Ala Val Cys Leu Leu Ala Cys Leu Leu Gly Val 
    130                 135                 140                 


Ala Leu Arg Lys Phe Lys Arg Arg Asn Gln Glu Arg Leu Asn Pro Arg 
145                 150                 155                 160 


Asp Val Glu Tyr Gly Xaa Ile Glu Gly Leu Ile Xaa Xaa Asn Val Gly 
                165                 170                 175     


Asp Ser Xaa Leu Ala Asp Leu Leu Asp His Ser Cys Xaa Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Leu Pro Phe Leu Val Gln Arg Xaa Val Ala Arg Gln Ile 
        195                 200                 205             


Xaa Leu Leu Glu Cys Val Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg 
    210                 215                 220                 


Gly Ser Trp Gln Gly Glu Asn Val Ala Val Lys Ile Phe Ser Ser Arg 
225                 230                 235                 240 


Asp Glu Lys Ser Trp Phe Arg Glu Xaa Glu Leu Tyr Asn Xaa Val Met 
                245                 250                 255     


Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ser Asp Met Xaa Ser 
            260                 265                 270         


Arg His Ser Ser Xaa Gln Leu Trp Leu Ile Xaa His Tyr His Glu Met 
        275                 280                 285             


Gly Ser Leu Tyr Asp Tyr Leu Gln Leu Xaa Xaa Leu Asp Xaa Val Ser 
    290                 295                 300                 


Cys Leu Arg Ile Val Leu Ser Ile Ala Ser Gly Leu Ala His Leu His 
305                 310                 315                 320 


Ile Glu Ile Phe Gly Xaa Gln Gly Lys Pro Ala Ile Ala His Arg Asp 
                325                 330                 335     


Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Gln Cys Cys Ile 
            340                 345                 350         


Ala Asp Leu Gly Leu Ala Val Met His Ser Gln Ser Xaa Asn Gln Leu 
        355                 360                 365             


Asp Val Gly Asn Asn Pro Arg Val Gly Xaa Lys Arg Tyr Met Ala Pro 
    370                 375                 380                 


Glu Val Leu Asp Glu Xaa Ile Gln Val Asp Cys Phe Asp Ser Tyr Lys 
385                 390                 395                 400 


Arg Val Asp Ile Trp Ala Phe Gly Leu Val Leu Trp Glu Val Ala Arg 
                405                 410                 415     


Arg Met Val Ser Asn Gly Ile Val Glu Asp Tyr Lys Pro Pro Phe Tyr 
            420                 425                 430         


Asp Val Val Pro Asn Asp Pro Ser Phe Glu Asp Met Arg Lys Val Val 
        435                 440                 445             


Cys Val Asp Gln Gln Arg Pro Asn Ile Pro Asn Arg Trp Phe Ser Asp 
    450                 455                 460                 


Pro Xaa Leu Xaa Ser Leu Ala Lys Leu Met Lys Glu Cys Trp Tyr Gln 
465                 470                 475                 480 


Asn Pro Ser Ala Arg Leu Xaa Ala Leu Arg Ile Lys Lys Xaa Leu Xaa 
                485                 490                 495     


Lys Ile Asp Asn Ser Leu Asp Lys Leu Lys Xaa Asp Cys 
            500                 505                 


<210> 1437
<211> 476
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<400> 1437
Met Ala Glu Ser Ala Gly Ala Ser Ser Phe Phe Pro Leu Val Val Leu 
1               5                   10                  15      


Leu Leu Ala Gly Ser Gly Gly Ser Gly Pro Arg Gly Val Gln Ala Leu 
            20                  25                  30          


Leu Cys Ala Cys Xaa Ser Cys Leu Gln Ala Asn Tyr Xaa Cys Glu Xaa 
        35                  40                  45              


Asp Gly Ala Cys Met Val Ser Ile Phe Asn Leu Asp Gly Met Glu His 
    50                  55                  60                  


His Val Arg Xaa Cys Ile Pro Lys Val Glu Leu Val Pro Ala Gly Lys 
65                  70                  75                  80  


Pro Phe Tyr Cys Leu Ser Ser Glu Asp Leu Arg Asn Xaa His Cys Cys 
                85                  90                  95      


Tyr Xaa Asp Tyr Cys Asn Arg Ile Asp Leu Arg Val Pro Ser Gly His 
            100                 105                 110         


Leu Lys Glu Pro Glu His Pro Ser Met Trp Gly Pro Val Glu Leu Val 
        115                 120                 125             


Gly Ile Ile Ala Gly Pro Val Phe Leu Leu Phe Leu Ile Ile Ile Ile 
    130                 135                 140                 


Val Phe Leu Val Ile Asn Tyr His Gln Arg Val Tyr His Asn Arg Gln 
145                 150                 155                 160 


Arg Leu Asp Met Glu Asp Pro Ser Cys Glu Met Cys Leu Ser Lys Asp 
                165                 170                 175     


Lys Xaa Leu Gln Asp Leu Val Tyr Asp Leu Ser Xaa Ser Gly Ser Gly 
            180                 185                 190         


Ser Gly Leu Pro Leu Phe Val Gln Arg Xaa Val Ala Arg Xaa Ile Val 
        195                 200                 205             


Leu Gln Glu Ile Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly 
    210                 215                 220                 


Arg Trp Arg Gly Gly Asp Val Ala Val Lys Ile Phe Ser Ser Arg Glu 
225                 230                 235                 240 


Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Xaa Val Met Leu 
                245                 250                 255     


Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn 
            260                 265                 270         


Gly Xaa Trp Xaa Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly 
        275                 280                 285             


Ser Leu Phe Asp Tyr Leu Asn Arg Tyr Xaa Val Xaa Ile Glu Gly Met 
    290                 295                 300                 


Ile Lys Leu Ala Leu Ser Ala Ala Ser Gly Leu Ala His Leu His Met 
305                 310                 315                 320 


Glu Ile Val Gly Xaa Gln Gly Lys Pro Gly Ile Ala His Arg Asp Leu 
                325                 330                 335     


Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Met Cys Ala Ile Ala 
            340                 345                 350         


Asp Leu Gly Leu Ala Val Arg His Asp Ala Val Xaa Asp Xaa Ile Asp 
        355                 360                 365             


Ile Ala Pro Asn Gln Arg Val Gly Xaa Lys Arg Tyr Met Ala Pro Glu 
    370                 375                 380                 


Val Leu Asp Glu Xaa Ile Asn Met Lys His Phe Asp Ser Phe Lys Cys 
385                 390                 395                 400 


Ala Asp Ile Tyr Ala Leu Gly Leu Val Tyr Trp Glu Ile Ala Arg Arg 
                405                 410                 415     


Cys Asn Ser Gly Gly Val His Glu Glu Tyr Gln Leu Pro Tyr Tyr Asp 
            420                 425                 430         


Leu Val Pro Ser Asp Pro Ser Ile Glu Glu Met Arg Lys Val Val Cys 
        435                 440                 445             


Asp Gln Lys Leu Arg Pro Asn Ile Pro Asn Trp Trp Gln Ser Tyr Glu 
    450                 455                 460                 


Val Arg Ser Trp Pro Pro Ala Ala Phe Pro Ser Ala 
465                 470                 475     


<210> 1438
<211> 487
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<400> 1438
Met Ala Glu Ser Ala Gly Ala Ser Ser Phe Phe Pro Leu Val Val Leu 
1               5                   10                  15      


Leu Leu Ala Gly Ser Gly Gly Ser Gly Pro Arg Gly Val Gln Ala Leu 
            20                  25                  30          


Leu Cys Ala Cys Xaa Ser Cys Leu Gln Ala Asn Tyr Xaa Cys Glu Xaa 
        35                  40                  45              


Asp Gly Ala Cys Met Val Ser Ile Phe Asn Leu Asp Gly Met Glu His 
    50                  55                  60                  


His Val Arg Xaa Cys Ile Pro Lys Val Glu Leu Val Pro Ala Gly Lys 
65                  70                  75                  80  


Pro Phe Tyr Cys Leu Ser Ser Glu Asp Leu Arg Asn Xaa His Cys Cys 
                85                  90                  95      


Tyr Xaa Asp Tyr Cys Asn Arg Ile Asp Leu Arg Val Pro Ser Gly His 
            100                 105                 110         


Leu Lys Glu Pro Glu His Pro Ser Met Trp Gly Pro Val Glu Leu Val 
        115                 120                 125             


Gly Ile Ile Ala Gly Pro Val Phe Leu Leu Phe Leu Ile Ile Ile Ile 
    130                 135                 140                 


Val Phe Leu Val Ile Asn Tyr His Gln Arg Val Tyr His Asn Arg Gln 
145                 150                 155                 160 


Arg Leu Asp Met Glu Asp Pro Ser Cys Glu Met Cys Leu Ser Lys Asp 
                165                 170                 175     


Lys Xaa Leu Gln Asp Leu Val Tyr Asp Leu Ser Xaa Ser Gly Ser Gly 
            180                 185                 190         


Ser Gly Leu Pro Leu Phe Val Gln Arg Xaa Val Ala Arg Xaa Ile Val 
        195                 200                 205             


Leu Gln Glu Ile Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly 
    210                 215                 220                 


Arg Trp Arg Gly Gly Asp Val Ala Val Lys Ile Phe Ser Ser Arg Glu 
225                 230                 235                 240 


Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Xaa Val Met Leu 
                245                 250                 255     


Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn 
            260                 265                 270         


Gly Xaa Trp Xaa Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly 
        275                 280                 285             


Ser Leu Phe Asp Tyr Leu Asn Arg Tyr Xaa Val Xaa Ile Glu Gly Met 
    290                 295                 300                 


Ile Lys Leu Ala Leu Ser Ala Ala Ser Gly Leu Ala His Leu His Met 
305                 310                 315                 320 


Glu Ile Val Gly Xaa Gln Gly Lys Pro Gly Ile Ala His Arg Asp Leu 
                325                 330                 335     


Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Met Cys Ala Ile Ala 
            340                 345                 350         


Asp Leu Gly Leu Ala Val Arg His Asp Ala Val Xaa Asp Xaa Ile Asp 
        355                 360                 365             


Ile Ala Pro Asn Gln Arg Val Gly Xaa Lys Arg Tyr Met Ala Pro Glu 
    370                 375                 380                 


Val Leu Asp Glu Xaa Ile Asn Met Lys His Phe Asp Ser Phe Lys Cys 
385                 390                 395                 400 


Ala Asp Ile Tyr Ala Leu Gly Leu Val Tyr Trp Glu Ile Ala Arg Arg 
                405                 410                 415     


Cys Asn Ser Gly Gly Xaa Phe Leu Phe Cys Leu Cys Ser Tyr Leu Pro 
            420                 425                 430         


Phe Gln Asp Ala Gly Ser Pro Lys Ala Val Leu Leu Pro Pro Phe Phe 
        435                 440                 445             


Leu Gln Pro Val Gly Cys Leu Leu Pro Glu Pro Glu Ser Ser Phe Lys 
    450                 455                 460                 


Val Ala Ile Lys Gly Val Glu Val Ala Val Leu Arg Val Arg Leu Phe 
465                 470                 475                 480 


Phe Arg Asp Gln Phe Val Glu 
                485         


<210> 1439
<211> 505
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<400> 1439
Met Ala Glu Ser Ala Gly Ala Ser Ser Phe Phe Pro Leu Val Val Leu 
1               5                   10                  15      


Leu Leu Ala Gly Ser Gly Gly Ser Gly Pro Arg Gly Val Gln Ala Leu 
            20                  25                  30          


Leu Cys Ala Cys Xaa Ser Cys Leu Gln Ala Asn Tyr Xaa Cys Glu Xaa 
        35                  40                  45              


Asp Gly Ala Cys Met Val Ser Ile Phe Asn Leu Asp Gly Met Glu His 
    50                  55                  60                  


His Val Arg Xaa Cys Ile Pro Lys Val Glu Leu Val Pro Ala Gly Lys 
65                  70                  75                  80  


Pro Phe Tyr Cys Leu Ser Ser Glu Asp Leu Arg Asn Xaa His Cys Cys 
                85                  90                  95      


Tyr Xaa Asp Tyr Cys Asn Arg Ile Asp Leu Arg Val Pro Ser Gly His 
            100                 105                 110         


Leu Lys Glu Pro Glu His Pro Ser Met Trp Gly Pro Val Glu Leu Val 
        115                 120                 125             


Gly Ile Ile Ala Gly Pro Val Phe Leu Leu Phe Leu Ile Ile Ile Ile 
    130                 135                 140                 


Val Phe Leu Val Ile Asn Tyr His Gln Arg Val Tyr His Asn Arg Gln 
145                 150                 155                 160 


Arg Leu Asp Met Glu Asp Pro Ser Cys Glu Met Cys Leu Ser Lys Asp 
                165                 170                 175     


Lys Xaa Leu Gln Asp Leu Val Tyr Asp Leu Ser Xaa Ser Gly Ser Gly 
            180                 185                 190         


Ser Gly Leu Pro Leu Phe Val Gln Arg Xaa Val Ala Arg Xaa Ile Val 
        195                 200                 205             


Leu Gln Glu Ile Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly 
    210                 215                 220                 


Arg Trp Arg Gly Gly Asp Val Ala Val Lys Ile Phe Ser Ser Arg Glu 
225                 230                 235                 240 


Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Xaa Val Met Leu 
                245                 250                 255     


Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn 
            260                 265                 270         


Gly Xaa Trp Xaa Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly 
        275                 280                 285             


Ser Leu Phe Asp Tyr Leu Asn Arg Tyr Xaa Val Xaa Ile Glu Gly Met 
    290                 295                 300                 


Ile Lys Leu Ala Leu Ser Ala Ala Ser Gly Leu Ala His Leu His Met 
305                 310                 315                 320 


Glu Ile Val Gly Xaa Gln Gly Lys Pro Gly Ile Ala His Arg Asp Leu 
                325                 330                 335     


Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Met Cys Ala Ile Ala 
            340                 345                 350         


Asp Leu Gly Leu Ala Val Arg His Asp Ala Val Xaa Asp Xaa Ile Asp 
        355                 360                 365             


Ile Ala Pro Asn Gln Arg Val Gly Xaa Lys Arg Tyr Met Ala Pro Glu 
    370                 375                 380                 


Val Leu Asp Glu Xaa Ile Asn Met Lys His Phe Asp Ser Phe Lys Cys 
385                 390                 395                 400 


Ala Asp Ile Tyr Ala Leu Gly Leu Val Tyr Trp Glu Ile Ala Arg Arg 
                405                 410                 415     


Cys Asn Ser Gly Gly Val His Glu Glu Tyr Gln Leu Pro Tyr Tyr Asp 
            420                 425                 430         


Leu Val Pro Ser Asp Pro Ser Ile Glu Glu Met Arg Lys Val Val Cys 
        435                 440                 445             


Asp Gln Lys Leu Arg Pro Asn Ile Pro Asn Trp Trp Gln Ser Tyr Glu 
    450                 455                 460                 


Ala Leu Arg Val Met Gly Lys Met Met Arg Glu Cys Trp Tyr Ala Asn 
465                 470                 475                 480 


Gly Ala Ala Arg Leu Xaa Ala Leu Arg Ile Lys Lys Xaa Leu Ser Gln 
                485                 490                 495     


Leu Ser Val Gln Glu Asp Val Lys Ile 
            500                 505 


<210> 1440
<211> 546
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<400> 1440
Met Ala Glu Ser Ala Gly Ala Ser Ser Phe Phe Pro Leu Val Val Leu 
1               5                   10                  15      


Leu Leu Ala Gly Ser Gly Gly Ser Gly Pro Arg Gly Val Gln Ala Leu 
            20                  25                  30          


Leu Cys Ala Cys Xaa Ser Cys Leu Gln Ala Asn Tyr Xaa Cys Glu Xaa 
        35                  40                  45              


Asp Gly Ala Cys Met Val Ser Ile Phe Asn Leu Asp Gly Met Glu His 
    50                  55                  60                  


His Val Arg Xaa Cys Ile Pro Lys Val Glu Leu Val Pro Ala Gly Lys 
65                  70                  75                  80  


Pro Phe Tyr Cys Leu Ser Ser Glu Asp Leu Arg Asn Xaa His Cys Cys 
                85                  90                  95      


Tyr Xaa Asp Tyr Cys Asn Arg Ile Asp Leu Arg Val Pro Ser Gly His 
            100                 105                 110         


Leu Lys Glu Pro Glu His Pro Ser Met Trp Gly Pro Val Glu Leu Val 
        115                 120                 125             


Gly Ile Ile Ala Gly Pro Val Phe Leu Leu Phe Leu Ile Ile Ile Ile 
    130                 135                 140                 


Val Phe Leu Val Ile Asn Tyr His Gln Arg Val Tyr His Asn Arg Gln 
145                 150                 155                 160 


Arg Leu Asp Met Glu Asp Pro Ser Cys Glu Met Cys Leu Ser Lys Asp 
                165                 170                 175     


Lys Xaa Leu Gln Asp Leu Val Tyr Asp Leu Ser Xaa Ser Gly Ser Gly 
            180                 185                 190         


Ser Gly Leu Pro Leu Phe Val Gln Arg Xaa Val Ala Arg Xaa Ile Val 
        195                 200                 205             


Leu Gln Glu Ile Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly 
    210                 215                 220                 


Arg Trp Arg Gly Gly Asp Val Ala Val Lys Ile Phe Ser Ser Arg Glu 
225                 230                 235                 240 


Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Xaa Val Met Leu 
                245                 250                 255     


Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Ala Asp 
            260                 265                 270         


Cys Ser Phe Leu Xaa Leu Pro Trp Glu Val Val Met Val Ser Ala Ala 
        275                 280                 285             


Pro Lys Leu Arg Ser Leu Arg Leu Gln Tyr Lys Gly Gly Arg Gly Arg 
    290                 295                 300                 


Ala Arg Phe Leu Phe Pro Leu Asn Asn Gly Xaa Trp Xaa Gln Leu Trp 
305                 310                 315                 320 


Leu Val Ser Asp Tyr His Glu His Gly Ser Leu Phe Asp Tyr Leu Asn 
                325                 330                 335     


Arg Tyr Xaa Val Xaa Ile Glu Gly Met Ile Lys Leu Ala Leu Ser Ala 
            340                 345                 350         


Ala Ser Gly Leu Ala His Leu His Met Glu Ile Val Gly Xaa Gln Gly 
        355                 360                 365             


Lys Pro Gly Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile Leu Val 
    370                 375                 380                 


Lys Lys Asn Gly Met Cys Ala Ile Ala Asp Leu Gly Leu Ala Val Arg 
385                 390                 395                 400 


His Asp Ala Val Xaa Asp Xaa Ile Asp Ile Ala Pro Asn Gln Arg Val 
                405                 410                 415     


Gly Xaa Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Xaa Ile Asn 
            420                 425                 430         


Met Lys His Phe Asp Ser Phe Lys Cys Ala Asp Ile Tyr Ala Leu Gly 
        435                 440                 445             


Leu Val Tyr Trp Glu Ile Ala Arg Arg Cys Asn Ser Gly Gly Val His 
    450                 455                 460                 


Glu Glu Tyr Gln Leu Pro Tyr Tyr Asp Leu Val Pro Ser Asp Pro Ser 
465                 470                 475                 480 


Ile Glu Glu Met Arg Lys Val Val Cys Asp Gln Lys Leu Arg Pro Asn 
                485                 490                 495     


Ile Pro Asn Trp Trp Gln Ser Tyr Glu Ala Leu Arg Val Met Gly Lys 
            500                 505                 510         


Met Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala Ala Arg Leu Xaa Ala 
        515                 520                 525             


Leu Arg Ile Lys Lys Xaa Leu Ser Gln Leu Ser Val Gln Glu Asp Val 
    530                 535                 540                 


Lys Ile 
545     


<210> 1441
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<400> 1441
Met Val Ser Ile Phe Asn Leu Asp Gly Met Glu His His Val Arg Xaa 
1               5                   10                  15      


Cys Ile Pro Lys Val Glu Leu Val Pro Ala Gly Lys Pro Phe Tyr Cys 
            20                  25                  30          


Leu Ser Ser Glu Asp Leu Arg Asn Xaa His Cys Cys Tyr Xaa Asp Tyr 
        35                  40                  45              


Cys Asn Arg Ile Asp Leu Arg Val Pro Ser Gly His Leu Lys Glu Pro 
    50                  55                  60                  


Glu His Pro Ser Met Trp Gly 
65                  70      


<210> 1442
<211> 453
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<400> 1442
Met Val Ser Ile Phe Asn Leu Asp Gly Met Glu His His Val Arg Xaa 
1               5                   10                  15      


Cys Ile Pro Lys Val Glu Leu Val Pro Ala Gly Lys Pro Phe Tyr Cys 
            20                  25                  30          


Leu Ser Ser Glu Asp Leu Arg Asn Xaa His Cys Cys Tyr Xaa Asp Tyr 
        35                  40                  45              


Cys Asn Arg Ile Asp Leu Arg Val Pro Ser Gly His Leu Lys Glu Pro 
    50                  55                  60                  


Glu His Pro Ser Met Trp Gly Pro Val Glu Leu Val Gly Ile Ile Ala 
65                  70                  75                  80  


Gly Pro Val Phe Leu Leu Phe Leu Ile Ile Ile Ile Val Phe Leu Val 
                85                  90                  95      


Ile Asn Tyr His Gln Arg Val Tyr His Asn Arg Gln Arg Leu Asp Met 
            100                 105                 110         


Glu Asp Pro Ser Cys Glu Met Cys Leu Ser Lys Asp Lys Xaa Leu Gln 
        115                 120                 125             


Asp Leu Val Tyr Asp Leu Ser Xaa Ser Gly Ser Gly Ser Gly Leu Pro 
    130                 135                 140                 


Leu Phe Val Gln Arg Xaa Val Ala Arg Xaa Ile Val Leu Gln Glu Ile 
145                 150                 155                 160 


Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Arg Trp Arg Gly 
                165                 170                 175     


Gly Asp Val Ala Val Lys Ile Phe Ser Ser Arg Glu Glu Arg Ser Trp 
            180                 185                 190         


Phe Arg Glu Ala Glu Ile Tyr Gln Xaa Val Met Leu Arg His Glu Asn 
        195                 200                 205             


Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Xaa Trp Xaa 
    210                 215                 220                 


Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu Phe Asp 
225                 230                 235                 240 


Tyr Leu Asn Arg Tyr Xaa Val Xaa Ile Glu Gly Met Ile Lys Leu Ala 
                245                 250                 255     


Leu Ser Ala Ala Ser Gly Leu Ala His Leu His Met Glu Ile Val Gly 
            260                 265                 270         


Xaa Gln Gly Lys Pro Gly Ile Ala His Arg Asp Leu Lys Ser Lys Asn 
        275                 280                 285             


Ile Leu Val Lys Lys Asn Gly Met Cys Ala Ile Ala Asp Leu Gly Leu 
    290                 295                 300                 


Ala Val Arg His Asp Ala Val Xaa Asp Xaa Ile Asp Ile Ala Pro Asn 
305                 310                 315                 320 


Gln Arg Val Gly Xaa Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu 
                325                 330                 335     


Xaa Ile Asn Met Lys His Phe Asp Ser Phe Lys Cys Ala Asp Ile Tyr 
            340                 345                 350         


Ala Leu Gly Leu Val Tyr Trp Glu Ile Ala Arg Arg Cys Asn Ser Gly 
        355                 360                 365             


Gly Val His Glu Glu Tyr Gln Leu Pro Tyr Tyr Asp Leu Val Pro Ser 
    370                 375                 380                 


Asp Pro Ser Ile Glu Glu Met Arg Lys Val Val Cys Asp Gln Lys Leu 
385                 390                 395                 400 


Arg Pro Asn Ile Pro Asn Trp Trp Gln Ser Tyr Glu Ala Leu Arg Val 
                405                 410                 415     


Met Gly Lys Met Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala Ala Arg 
            420                 425                 430         


Leu Xaa Ala Leu Arg Ile Lys Lys Xaa Leu Ser Gln Leu Ser Val Gln 
        435                 440                 445             


Glu Asp Val Lys Ile 
    450             


<210> 1443
<211> 443
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<400> 1443
Met Leu Xaa Asn Gly Lys Glu Gln Val Ile Lys Ser Cys Val Ser Leu 
1               5                   10                  15      


Pro Glu Leu Asn Ala Gln Val Phe Cys His Ser Ser Asn Asn Val Xaa 
            20                  25                  30          


Lys Xaa Glu Cys Cys Phe Xaa Asp Phe Cys Asn Asn Ile Xaa Leu His 
        35                  40                  45              


Leu Pro Xaa Ala Ser Pro Asn Ala Pro Lys Leu Gly Pro Met Glu Leu 
    50                  55                  60                  


Ala Ile Ile Ile Xaa Val Pro Val Cys Leu Leu Ser Ile Ala Ala Met 
65                  70                  75                  80  


Leu Xaa Val Trp Ala Cys Gln Gly Arg Gln Cys Ser Tyr Arg Lys Lys 
                85                  90                  95      


Lys Arg Pro Asn Val Glu Glu Pro Leu Ser Glu Cys Asn Leu Val Asn 
            100                 105                 110         


Ala Gly Lys Xaa Leu Lys Asp Leu Ile Tyr Asp Val Xaa Ala Ser Gly 
        115                 120                 125             


Ser Gly Ser Gly Leu Pro Leu Leu Val Gln Arg Xaa Ile Ala Arg Xaa 
    130                 135                 140                 


Ile Val Leu Gln Glu Ile Val Gly Lys Gly Arg Phe Gly Glu Val Trp 
145                 150                 155                 160 


His Gly Arg Trp Cys Gly Glu Asp Val Ala Val Lys Ile Phe Ser Ser 
                165                 170                 175     


Arg Asp Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Xaa Val 
            180                 185                 190         


Met Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys 
        195                 200                 205             


Asp Asn Gly Xaa Trp Xaa Gln Leu Trp Leu Val Ser Glu Tyr His Glu 
    210                 215                 220                 


Gln Gly Ser Leu Tyr Asp Tyr Leu Asn Arg Asn Ile Val Xaa Val Ala 
225                 230                 235                 240 


Gly Met Ile Lys Leu Ala Leu Ser Ile Ala Ser Gly Leu Ala His Leu 
                245                 250                 255     


His Met Glu Ile Val Gly Xaa Gln Gly Lys Pro Ala Ile Ala His Arg 
            260                 265                 270         


Asp Ile Lys Ser Lys Asn Ile Leu Val Lys Lys Cys Glu Xaa Cys Ala 
        275                 280                 285             


Ile Ala Asp Leu Gly Leu Ala Val Lys His Asp Ser Ile Leu Asn Xaa 
    290                 295                 300                 


Ile Asp Ile Pro Gln Asn Pro Lys Val Gly Xaa Lys Arg Tyr Met Ala 
305                 310                 315                 320 


Pro Glu Met Leu Asp Asp Xaa Met Asn Val Asn Ile Phe Glu Ser Phe 
                325                 330                 335     


Lys Arg Ala Asp Ile Tyr Ser Val Gly Leu Val Tyr Trp Glu Ile Ala 
            340                 345                 350         


Arg Arg Cys Ser Val Gly Gly Ile Val Glu Glu Tyr Gln Leu Pro Tyr 
        355                 360                 365             


Tyr Asp Met Val Pro Ser Asp Pro Ser Ile Glu Glu Met Arg Lys Val 
    370                 375                 380                 


Val Cys Asp Gln Lys Phe Arg Pro Ser Ile Pro Asn Gln Trp Gln Ser 
385                 390                 395                 400 


Cys Glu Ala Leu Arg Val Met Gly Arg Ile Met Arg Glu Cys Trp Tyr 
                405                 410                 415     


Ala Asn Gly Ala Ala Arg Leu Xaa Ala Leu Arg Ile Lys Lys Xaa Ile 
            420                 425                 430         


Ser Gln Leu Cys Val Lys Glu Asp Cys Lys Ala 
        435                 440             


<210> 1444
<211> 493
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<400> 1444
Met Xaa Arg Ala Leu Cys Ser Ala Leu Arg Gln Ala Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Ala Glu Leu Ser Pro Gly Leu Lys Cys Val Cys Leu Leu 
            20                  25                  30          


Cys Asp Ser Ser Asn Phe Xaa Cys Gln Xaa Glu Gly Ala Cys Trp Ala 
        35                  40                  45              


Ser Val Met Leu Xaa Asn Gly Lys Glu Gln Val Ile Lys Ser Cys Val 
    50                  55                  60                  


Ser Leu Pro Glu Leu Asn Ala Gln Val Phe Cys His Ser Ser Asn Asn 
65                  70                  75                  80  


Val Xaa Lys Xaa Glu Cys Cys Phe Xaa Asp Phe Cys Asn Asn Ile Xaa 
                85                  90                  95      


Leu His Leu Pro Xaa Ala Ser Pro Asn Ala Pro Lys Leu Gly Pro Met 
            100                 105                 110         


Glu Leu Ala Ile Ile Ile Xaa Val Pro Val Cys Leu Leu Ser Ile Ala 
        115                 120                 125             


Ala Met Leu Xaa Val Trp Ala Cys Gln Gly Arg Gln Cys Ser Tyr Arg 
    130                 135                 140                 


Lys Lys Lys Arg Pro Asn Val Glu Glu Pro Leu Ser Glu Cys Asn Leu 
145                 150                 155                 160 


Val Asn Ala Gly Lys Xaa Leu Lys Asp Leu Ile Tyr Asp Val Xaa Ala 
                165                 170                 175     


Ser Gly Ser Gly Ser Gly Leu Pro Leu Leu Val Gln Arg Xaa Ile Ala 
            180                 185                 190         


Arg Xaa Ile Val Leu Gln Glu Ile Val Gly Lys Gly Arg Phe Gly Glu 
        195                 200                 205             


Val Trp His Gly Arg Trp Cys Gly Glu Asp Val Ala Val Lys Ile Phe 
    210                 215                 220                 


Ser Ser Arg Asp Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln 
225                 230                 235                 240 


Xaa Val Met Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp 
                245                 250                 255     


Asn Lys Asp Asn Gly Xaa Trp Xaa Gln Leu Trp Leu Val Ser Glu Tyr 
            260                 265                 270         


His Glu Gln Gly Ser Leu Tyr Asp Tyr Leu Asn Arg Asn Ile Val Xaa 
        275                 280                 285             


Val Ala Gly Met Ile Lys Leu Ala Leu Ser Ile Ala Ser Gly Leu Ala 
    290                 295                 300                 


His Leu His Met Glu Ile Val Gly Xaa Gln Gly Lys Pro Ala Ile Ala 
305                 310                 315                 320 


His Arg Asp Ile Lys Ser Lys Asn Ile Leu Val Lys Lys Cys Glu Xaa 
                325                 330                 335     


Cys Ala Ile Ala Asp Leu Gly Leu Ala Val Lys His Asp Ser Ile Leu 
            340                 345                 350         


Asn Xaa Ile Asp Ile Pro Gln Asn Pro Lys Val Gly Xaa Lys Arg Tyr 
        355                 360                 365             


Met Ala Pro Glu Met Leu Asp Asp Xaa Met Asn Val Asn Ile Phe Glu 
    370                 375                 380                 


Ser Phe Lys Arg Ala Asp Ile Tyr Ser Val Gly Leu Val Tyr Trp Glu 
385                 390                 395                 400 


Ile Ala Arg Arg Cys Ser Val Gly Gly Ile Val Glu Glu Tyr Gln Leu 
                405                 410                 415     


Pro Tyr Tyr Asp Met Val Pro Ser Asp Pro Ser Ile Glu Glu Met Arg 
            420                 425                 430         


Lys Val Val Cys Asp Gln Lys Phe Arg Pro Ser Ile Pro Asn Gln Trp 
        435                 440                 445             


Gln Ser Cys Glu Ala Leu Arg Val Met Gly Arg Ile Met Arg Glu Cys 
    450                 455                 460                 


Trp Tyr Ala Asn Gly Ala Ala Arg Leu Xaa Ala Leu Arg Ile Lys Lys 
465                 470                 475                 480 


Xaa Ile Ser Gln Leu Cys Val Lys Glu Asp Cys Lys Ala 
                485                 490             


<210> 1445
<211> 336
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<400> 1445
Met Xaa Arg Ala Leu Cys Ser Ala Leu Arg Gln Ala Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Ala Glu Leu Ser Pro Gly Leu Lys Cys Val Cys Leu Leu 
            20                  25                  30          


Cys Asp Ser Ser Asn Phe Xaa Cys Gln Xaa Glu Gly Ala Cys Trp Ala 
        35                  40                  45              


Ser Val Met Leu Xaa Asn Gly Lys Glu Gln Val Ile Lys Ser Cys Val 
    50                  55                  60                  


Ser Leu Pro Glu Leu Asn Ala Gln Val Phe Cys His Ser Ser Asn Asn 
65                  70                  75                  80  


Val Xaa Lys Xaa Glu Cys Cys Phe Xaa Asp Phe Cys Asn Asn Ile Xaa 
                85                  90                  95      


Leu His Leu Pro Xaa Asp Asn Gly Xaa Trp Xaa Gln Leu Trp Leu Val 
            100                 105                 110         


Ser Glu Tyr His Glu Gln Gly Ser Leu Tyr Asp Tyr Leu Asn Arg Asn 
        115                 120                 125             


Ile Val Xaa Val Ala Gly Met Ile Lys Leu Ala Leu Ser Ile Ala Ser 
    130                 135                 140                 


Gly Leu Ala His Leu His Met Glu Ile Val Gly Xaa Gln Gly Lys Pro 
145                 150                 155                 160 


Ala Ile Ala His Arg Asp Ile Lys Ser Lys Asn Ile Leu Val Lys Lys 
                165                 170                 175     


Cys Glu Xaa Cys Ala Ile Ala Asp Leu Gly Leu Ala Val Lys His Asp 
            180                 185                 190         


Ser Ile Leu Asn Xaa Ile Asp Ile Pro Gln Asn Pro Lys Val Gly Xaa 
        195                 200                 205             


Lys Arg Tyr Met Ala Pro Glu Met Leu Asp Asp Xaa Met Asn Val Asn 
    210                 215                 220                 


Ile Phe Glu Ser Phe Lys Arg Ala Asp Ile Tyr Ser Val Gly Leu Val 
225                 230                 235                 240 


Tyr Trp Glu Ile Ala Arg Arg Cys Ser Val Gly Gly Ile Val Glu Glu 
                245                 250                 255     


Tyr Gln Leu Pro Tyr Tyr Asp Met Val Pro Ser Asp Pro Ser Ile Glu 
            260                 265                 270         


Glu Met Arg Lys Val Val Cys Asp Gln Lys Phe Arg Pro Ser Ile Pro 
        275                 280                 285             


Asn Gln Trp Gln Ser Cys Glu Ala Leu Arg Val Met Gly Arg Ile Met 
    290                 295                 300                 


Arg Glu Cys Trp Tyr Ala Asn Gly Ala Ala Arg Leu Xaa Ala Leu Arg 
305                 310                 315                 320 


Ile Lys Lys Xaa Ile Ser Gln Leu Cys Val Lys Glu Asp Cys Lys Ala 
                325                 330                 335     


<210> 1446
<211> 413
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<400> 1446
Met Xaa Arg Ala Leu Cys Ser Ala Leu Arg Gln Ala Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Ala Glu Leu Ser Pro Gly Leu Lys Cys Val Cys Leu Leu 
            20                  25                  30          


Cys Asp Ser Ser Asn Phe Xaa Cys Gln Xaa Glu Gly Ala Cys Trp Ala 
        35                  40                  45              


Ser Val Met Leu Xaa Asn Gly Lys Glu Gln Val Ile Lys Ser Cys Val 
    50                  55                  60                  


Ser Leu Pro Glu Leu Asn Ala Gln Val Phe Cys His Ser Ser Asn Asn 
65                  70                  75                  80  


Val Xaa Lys Xaa Glu Cys Cys Phe Xaa Asp Phe Cys Asn Asn Ile Xaa 
                85                  90                  95      


Leu His Leu Pro Xaa Gly Leu Pro Leu Leu Val Gln Arg Xaa Ile Ala 
            100                 105                 110         


Arg Xaa Ile Val Leu Gln Glu Ile Val Gly Lys Gly Arg Phe Gly Glu 
        115                 120                 125             


Val Trp His Gly Arg Trp Cys Gly Glu Asp Val Ala Val Lys Ile Phe 
    130                 135                 140                 


Ser Ser Arg Asp Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln 
145                 150                 155                 160 


Xaa Val Met Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp 
                165                 170                 175     


Asn Lys Asp Asn Gly Xaa Trp Xaa Gln Leu Trp Leu Val Ser Glu Tyr 
            180                 185                 190         


His Glu Gln Gly Ser Leu Tyr Asp Tyr Leu Asn Arg Asn Ile Val Xaa 
        195                 200                 205             


Val Ala Gly Met Ile Lys Leu Ala Leu Ser Ile Ala Ser Gly Leu Ala 
    210                 215                 220                 


His Leu His Met Glu Ile Val Gly Xaa Gln Gly Lys Pro Ala Ile Ala 
225                 230                 235                 240 


His Arg Asp Ile Lys Ser Lys Asn Ile Leu Val Lys Lys Cys Glu Xaa 
                245                 250                 255     


Cys Ala Ile Ala Asp Leu Gly Leu Ala Val Lys His Asp Ser Ile Leu 
            260                 265                 270         


Asn Xaa Ile Asp Ile Pro Gln Asn Pro Lys Val Gly Xaa Lys Arg Tyr 
        275                 280                 285             


Met Ala Pro Glu Met Leu Asp Asp Xaa Met Asn Val Asn Ile Phe Glu 
    290                 295                 300                 


Ser Phe Lys Arg Ala Asp Ile Tyr Ser Val Gly Leu Val Tyr Trp Glu 
305                 310                 315                 320 


Ile Ala Arg Arg Cys Ser Val Gly Gly Ile Val Glu Glu Tyr Gln Leu 
                325                 330                 335     


Pro Tyr Tyr Asp Met Val Pro Ser Asp Pro Ser Ile Glu Glu Met Arg 
            340                 345                 350         


Lys Val Val Cys Asp Gln Lys Phe Arg Pro Ser Ile Pro Asn Gln Trp 
        355                 360                 365             


Gln Ser Cys Glu Ala Leu Arg Val Met Gly Arg Ile Met Arg Glu Cys 
    370                 375                 380                 


Trp Tyr Ala Asn Gly Ala Ala Arg Leu Xaa Ala Leu Arg Ile Lys Lys 
385                 390                 395                 400 


Xaa Ile Ser Gln Leu Cys Val Lys Glu Asp Cys Lys Ala 
                405                 410             


<210> 1447
<211> 405
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<400> 1447
Met Cys Asn Glu Lys Phe Ser Tyr Phe Pro Glu Met Glu Val Xaa Gln 
1               5                   10                  15      


Pro Xaa Ser Asn Pro Val Xaa Pro Lys Pro Pro Tyr Tyr Asn Ile Leu 
            20                  25                  30          


Leu Tyr Ser Leu Val Pro Leu Met Leu Ile Ala Gly Ile Val Ile Cys 
        35                  40                  45              


Ala Phe Trp Val Tyr Arg His His Lys Met Ala Tyr Pro Pro Val Leu 
    50                  55                  60                  


Val Pro Xaa Gln Asp Pro Gly Pro Pro Pro Pro Ser Pro Leu Leu Gly 
65                  70                  75                  80  


Leu Lys Pro Leu Gln Leu Leu Glu Val Lys Ala Arg Gly Arg Phe Gly 
                85                  90                  95      


Cys Val Trp Lys Ala Gln Leu Leu Asn Glu Tyr Val Ala Val Lys Ile 
            100                 105                 110         


Phe Pro Ile Gln Asp Lys Gln Ser Trp Gln Asn Glu Tyr Glu Val Tyr 
        115                 120                 125             


Ser Leu Pro Gly Met Lys His Glu Asn Ile Leu Gln Phe Ile Gly Ala 
    130                 135                 140                 


Glu Lys Arg Gly Xaa Ser Val Asp Val Asp Leu Trp Leu Ile Xaa Ala 
145                 150                 155                 160 


Phe His Glu Lys Gly Ser Leu Ser Asp Phe Leu Lys Ala Asn Val Val 
                165                 170                 175     


Ser Trp Asn Glu Leu Cys His Ile Ala Glu Xaa Met Ala Arg Gly Leu 
            180                 185                 190         


Ala Tyr Leu His Glu Asp Ile Pro Gly Leu Lys Asp Gly His Lys Pro 
        195                 200                 205             


Ala Ile Ser His Arg Asp Ile Lys Ser Lys Asn Val Leu Leu Lys Asn 
    210                 215                 220                 


Asn Leu Xaa Ala Cys Ile Ala Asp Phe Gly Leu Ala Leu Lys Phe Glu 
225                 230                 235                 240 


Ala Gly Lys Ser Ala Gly Asp Xaa His Gly Gln Val Gly Xaa Arg Arg 
                245                 250                 255     


Tyr Met Ala Pro Glu Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp 
            260                 265                 270         


Ala Phe Leu Arg Ile Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu 
        275                 280                 285             


Leu Ala Ser Arg Cys Xaa Ala Ala Asp Gly Pro Val Asp Glu Tyr Met 
    290                 295                 300                 


Leu Pro Phe Glu Glu Glu Ile Gly Gln His Pro Ser Leu Glu Asp Met 
305                 310                 315                 320 


Gln Glu Val Val Val His Lys Lys Lys Arg Pro Val Leu Arg Asp Tyr 
                325                 330                 335     


Trp Gln Lys His Ala Gly Met Ala Met Leu Cys Glu Xaa Ile Glu Glu 
            340                 345                 350         


Cys Trp Asp His Asp Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Gly 
        355                 360                 365             


Glu Arg Ile Xaa Gln Met Gln Arg Leu Xaa Asn Ile Ile Xaa Xaa Glu 
    370                 375                 380                 


Asp Ile Val Xaa Val Val Xaa Met Val Xaa Asn Val Asp Phe Pro Pro 
385                 390                 395                 400 


Lys Glu Ser Ser Leu 
                405 


<210> 1448
<211> 513
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<400> 1448
Met Gly Ala Ala Ala Lys Leu Ala Phe Ala Val Phe Leu Ile Ser Cys 
1               5                   10                  15      


Ser Ser Gly Ala Ile Leu Gly Arg Ser Glu Xaa Gln Glu Cys Leu Phe 
            20                  25                  30          


Phe Asn Ala Asn Trp Glu Lys Asp Arg Xaa Asn Gln Xaa Gly Val Glu 
        35                  40                  45              


Pro Cys Tyr Gly Asp Lys Asp Lys Arg Arg His Cys Phe Ala Xaa Trp 
    50                  55                  60                  


Lys Asn Ile Ser Gly Ser Ile Glu Ile Val Lys Gln Gly Cys Trp Leu 
65                  70                  75                  80  


Asp Asp Ile Asn Cys Tyr Asp Arg Xaa Asp Cys Val Glu Lys Lys Asp 
                85                  90                  95      


Ser Pro Glu Val Tyr Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu 
            100                 105                 110         


Lys Phe Ser Tyr Phe Pro Glu Met Glu Val Xaa Gln Pro Xaa Ser Asn 
        115                 120                 125             


Pro Val Xaa Pro Lys Pro Pro Tyr Tyr Asn Ile Leu Leu Tyr Ser Leu 
    130                 135                 140                 


Val Pro Leu Met Leu Ile Ala Gly Ile Val Ile Cys Ala Phe Trp Val 
145                 150                 155                 160 


Tyr Arg His His Lys Met Ala Tyr Pro Pro Val Leu Val Pro Xaa Gln 
                165                 170                 175     


Asp Pro Gly Pro Pro Pro Pro Ser Pro Leu Leu Gly Leu Lys Pro Leu 
            180                 185                 190         


Gln Leu Leu Glu Val Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys 
        195                 200                 205             


Ala Gln Leu Leu Asn Glu Tyr Val Ala Val Lys Ile Phe Pro Ile Gln 
    210                 215                 220                 


Asp Lys Gln Ser Trp Gln Asn Glu Tyr Glu Val Tyr Ser Leu Pro Gly 
225                 230                 235                 240 


Met Lys His Glu Asn Ile Leu Gln Phe Ile Gly Ala Glu Lys Arg Gly 
                245                 250                 255     


Xaa Ser Val Asp Val Asp Leu Trp Leu Ile Xaa Ala Phe His Glu Lys 
            260                 265                 270         


Gly Ser Leu Ser Asp Phe Leu Lys Ala Asn Val Val Ser Trp Asn Glu 
        275                 280                 285             


Leu Cys His Ile Ala Glu Xaa Met Ala Arg Gly Leu Ala Tyr Leu His 
    290                 295                 300                 


Glu Asp Ile Pro Gly Leu Lys Asp Gly His Lys Pro Ala Ile Ser His 
305                 310                 315                 320 


Arg Asp Ile Lys Ser Lys Asn Val Leu Leu Lys Asn Asn Leu Xaa Ala 
                325                 330                 335     


Cys Ile Ala Asp Phe Gly Leu Ala Leu Lys Phe Glu Ala Gly Lys Ser 
            340                 345                 350         


Ala Gly Asp Xaa His Gly Gln Val Gly Xaa Arg Arg Tyr Met Ala Pro 
        355                 360                 365             


Glu Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg 
    370                 375                 380                 


Ile Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Ala Ser Arg 
385                 390                 395                 400 


Cys Xaa Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu 
                405                 410                 415     


Glu Glu Ile Gly Gln His Pro Ser Leu Glu Asp Met Gln Glu Val Val 
            420                 425                 430         


Val His Lys Lys Lys Arg Pro Val Leu Arg Asp Tyr Trp Gln Lys His 
        435                 440                 445             


Ala Gly Met Ala Met Leu Cys Glu Xaa Ile Glu Glu Cys Trp Asp His 
    450                 455                 460                 


Asp Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Gly Glu Arg Ile Xaa 
465                 470                 475                 480 


Gln Met Gln Arg Leu Xaa Asn Ile Ile Xaa Xaa Glu Asp Ile Val Xaa 
                485                 490                 495     


Val Val Xaa Met Val Xaa Asn Val Asp Phe Pro Pro Lys Glu Ser Ser 
            500                 505                 510         


Leu 
    


<210> 1449
<211> 512
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<400> 1449
Met Xaa Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 
1               5                   10                  15      


Ala Gly Ser Gly Arg Gly Glu Ala Glu Xaa Arg Glu Cys Ile Tyr Tyr 
            20                  25                  30          


Asn Ala Asn Trp Glu Leu Glu Arg Xaa Asn Gln Ser Gly Leu Glu Arg 
        35                  40                  45              


Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg 
    50                  55                  60                  


Asn Ser Ser Gly Xaa Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp 
65                  70                  75                  80  


Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Xaa Glu Glu Asn 
                85                  90                  95      


Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg 
            100                 105                 110         


Phe Xaa His Leu Pro Glu Ala Gly Gly Pro Glu Val Xaa Tyr Glu Pro 
        115                 120                 125             


Pro Pro Xaa Ala Pro Xaa Leu Leu Xaa Val Leu Ala Tyr Ser Leu Leu 
    130                 135                 140                 


Pro Ile Gly Gly Leu Ser Leu Ile Val Leu Leu Ala Phe Trp Met Tyr 
145                 150                 155                 160 


Arg His Arg Lys Pro Pro Tyr Gly His Val Asp Ile His Glu Asp Pro 
                165                 170                 175     


Gly Pro Pro Pro Pro Ser Pro Leu Val Gly Leu Lys Pro Leu Gln Leu 
            180                 185                 190         


Leu Glu Ile Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys Ala Gln 
        195                 200                 205             


Leu Met Asn Asp Phe Val Ala Val Lys Ile Phe Pro Leu Gln Asp Lys 
    210                 215                 220                 


Gln Ser Trp Gln Ser Glu Arg Glu Ile Phe Ser Xaa Pro Gly Met Lys 
225                 230                 235                 240 


His Glu Asn Leu Leu Gln Phe Ile Ala Ala Glu Lys Arg Gly Ser Asn 
                245                 250                 255     


Leu Glu Val Glu Leu Trp Leu Ile Xaa Ala Phe His Asp Lys Gly Ser 
            260                 265                 270         


Leu Xaa Asp Tyr Leu Lys Gly Asn Ile Ile Xaa Trp Asn Glu Leu Cys 
        275                 280                 285             


His Val Ala Glu Xaa Met Ser Arg Gly Leu Ser Tyr Leu His Glu Asp 
    290                 295                 300                 


Val Pro Trp Cys Arg Gly Glu Gly His Lys Pro Ser Ile Ala His Arg 
305                 310                 315                 320 


Asp Phe Lys Ser Lys Asn Val Leu Leu Lys Ser Asp Leu Xaa Ala Val 
                325                 330                 335     


Leu Ala Asp Phe Gly Leu Ala Val Arg Phe Glu Pro Gly Lys Pro Pro 
            340                 345                 350         


Gly Asp Xaa His Gly Gln Val Gly Xaa Arg Arg Tyr Met Ala Pro Glu 
        355                 360                 365             


Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg Ile 
    370                 375                 380                 


Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Val Ser Arg Cys 
385                 390                 395                 400 


Lys Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu Glu 
                405                 410                 415     


Glu Ile Gly Gln His Pro Ser Leu Glu Glu Leu Gln Glu Val Val Val 
            420                 425                 430         


His Lys Lys Met Arg Pro Xaa Ile Lys Asp His Trp Leu Lys His Pro 
        435                 440                 445             


Gly Leu Ala Gln Leu Cys Val Xaa Ile Glu Glu Cys Trp Asp His Asp 
    450                 455                 460                 


Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Glu Glu Arg Val Ser Leu 
465                 470                 475                 480 


Ile Arg Arg Ser Val Asn Gly Xaa Xaa Ser Asp Cys Leu Val Ser Leu 
                485                 490                 495     


Val Xaa Ser Val Xaa Asn Val Asp Leu Pro Pro Lys Glu Ser Ser Ile 
            500                 505                 510         


<210> 1450
<211> 517
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<400> 1450
Met Ala Leu Xaa Pro Pro Leu Leu Leu Leu Ser Ala Gly Xaa Met Xaa 
1               5                   10                  15      


Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala Leu Val 
            20                  25                  30          


Xaa Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro Leu Val Xaa Cys 
        35                  40                  45              


Xaa Cys Glu Ser Pro His Cys Lys Gly Pro Xaa Cys Arg Gly Ala Trp 
    50                  55                  60                  


Cys Xaa Val Val Leu Val Arg Glu Glu Gly Arg His Pro Gln Glu His 
65                  70                  75                  80  


Arg Gly Cys Gly Asn Leu His Arg Glu Leu Cys Arg Gly Arg Pro Xaa 
                85                  90                  95      


Glu Phe Val Asn His Tyr Cys Cys Asp Ser His Leu Cys Asn His Asn 
            100                 105                 110         


Val Ser Leu Val Leu Glu Ala Xaa Gln Pro Pro Ser Glu Gln Pro Gly 
        115                 120                 125             


Xaa Asp Gly Gln Leu Ala Leu Ile Leu Gly Pro Val Leu Ala Leu Leu 
    130                 135                 140                 


Ala Leu Val Ala Leu Gly Val Leu Gly Leu Trp His Val Arg Arg Arg 
145                 150                 155                 160 


Gln Glu Lys Gln Arg Gly Leu His Ser Glu Leu Gly Glu Ser Ser Leu 
                165                 170                 175     


Ile Leu Lys Ala Ser Glu Gln Gly Asp Ser Met Leu Gly Asp Leu Leu 
            180                 185                 190         


Asp Ser Asp Cys Xaa Xaa Gly Ser Gly Ser Gly Leu Pro Phe Leu Val 
        195                 200                 205             


Gln Arg Xaa Val Ala Arg Gln Val Ala Leu Val Glu Cys Val Gly Lys 
    210                 215                 220                 


Gly Arg Tyr Gly Glu Val Trp Arg Gly Leu Trp His Gly Glu Ser Val 
225                 230                 235                 240 


Ala Val Lys Ile Phe Ser Ser Arg Asp Glu Gln Ser Trp Phe Arg Glu 
                245                 250                 255     


Xaa Glu Ile Tyr Asn Xaa Val Leu Leu Arg His Asp Asn Ile Leu Gly 
            260                 265                 270         


Phe Ile Ala Ser Asp Met Xaa Ser Arg Asn Ser Ser Xaa Gln Leu Trp 
        275                 280                 285             


Leu Ile Xaa His Tyr His Glu His Gly Ser Leu Tyr Asp Phe Leu Gln 
    290                 295                 300                 


Arg Gln Xaa Leu Glu Pro His Leu Ala Leu Arg Leu Ala Val Ser Ala 
305                 310                 315                 320 


Ala Cys Gly Leu Ala His Leu His Val Glu Ile Phe Gly Xaa Gln Gly 
                325                 330                 335     


Lys Pro Ala Ile Ala His Arg Asp Phe Lys Ser Arg Asn Val Leu Val 
            340                 345                 350         


Lys Ser Asn Leu Gln Cys Cys Ile Ala Asp Leu Gly Leu Ala Val Met 
        355                 360                 365             


His Ser Gln Gly Ser Asp Tyr Leu Asp Ile Gly Asn Asn Pro Arg Val 
    370                 375                 380                 


Gly Xaa Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Gln Ile Arg 
385                 390                 395                 400 


Xaa Asp Cys Phe Glu Ser Tyr Lys Trp Xaa Asp Ile Trp Ala Phe Gly 
                405                 410                 415     


Leu Val Leu Trp Glu Ile Ala Arg Arg Xaa Ile Val Asn Gly Ile Val 
            420                 425                 430         


Glu Asp Tyr Arg Pro Pro Phe Tyr Asp Val Val Pro Asn Asp Pro Ser 
        435                 440                 445             


Phe Glu Asp Met Lys Lys Val Val Cys Val Asp Gln Gln Xaa Pro Xaa 
    450                 455                 460                 


Ile Pro Asn Arg Leu Ala Ala Asp Pro Val Leu Ser Gly Leu Ala Gln 
465                 470                 475                 480 


Met Met Arg Glu Cys Trp Tyr Pro Asn Pro Ser Ala Arg Leu Xaa Ala 
                485                 490                 495     


Leu Arg Ile Lys Lys Xaa Leu Gln Lys Ile Ser Asn Ser Pro Glu Lys 
            500                 505                 510         


Pro Lys Val Ile Gln 
        515         


<210> 1451
<211> 159
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<400> 1451
Met Ala Leu Xaa Pro Pro Leu Leu Leu Leu Ser Ala Gly Xaa Met Xaa 
1               5                   10                  15      


Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala Leu Val 
            20                  25                  30          


Xaa Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro Leu Val Xaa Cys 
        35                  40                  45              


Xaa Cys Glu Ser Pro His Cys Lys Gly Pro Xaa Cys Arg Gly Ala Trp 
    50                  55                  60                  


Cys Xaa Val Val Leu Val Arg Glu Glu Gly Arg His Pro Gln Glu His 
65                  70                  75                  80  


Arg Gly Cys Gly Asn Leu His Arg Glu Leu Cys Arg Gly Arg Pro Xaa 
                85                  90                  95      


Glu Phe Val Asn His Tyr Cys Cys Asp Ser His Leu Cys Asn His Asn 
            100                 105                 110         


Val Ser Leu Val Leu Glu Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg 
        115                 120                 125             


Gly Leu Trp His Gly Glu Ser Val Ala Val Lys Ile Phe Ser Ser Arg 
    130                 135                 140                 


Asp Glu Gln Ser Trp Phe Arg Glu Xaa Glu Ile Tyr Asn Xaa Val 
145                 150                 155                 


<210> 1452
<211> 329
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<400> 1452
Met Ala Leu Xaa Pro Pro Leu Leu Leu Leu Ser Ala Gly Xaa Met Xaa 
1               5                   10                  15      


Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala Leu Val 
            20                  25                  30          


Xaa Gln Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg Gly Leu Trp His 
        35                  40                  45              


Gly Glu Ser Val Ala Val Lys Ile Phe Ser Ser Arg Asp Glu Gln Ser 
    50                  55                  60                  


Trp Phe Arg Glu Xaa Glu Ile Tyr Asn Xaa Val Leu Leu Arg His Asp 
65                  70                  75                  80  


Asn Ile Leu Gly Phe Ile Ala Ser Asp Met Xaa Ser Arg Asn Ser Ser 
                85                  90                  95      


Xaa Gln Leu Trp Leu Ile Xaa His Tyr His Glu His Gly Ser Leu Tyr 
            100                 105                 110         


Asp Phe Leu Gln Arg Gln Xaa Leu Glu Pro His Leu Ala Leu Arg Leu 
        115                 120                 125             


Ala Val Ser Ala Ala Cys Gly Leu Ala His Leu His Val Glu Ile Phe 
    130                 135                 140                 


Gly Xaa Gln Gly Lys Pro Ala Ile Ala His Arg Asp Phe Lys Ser Arg 
145                 150                 155                 160 


Asn Val Leu Val Lys Ser Asn Leu Gln Cys Cys Ile Ala Asp Leu Gly 
                165                 170                 175     


Leu Ala Val Met His Ser Gln Gly Ser Asp Tyr Leu Asp Ile Gly Asn 
            180                 185                 190         


Asn Pro Arg Val Gly Xaa Lys Arg Tyr Met Ala Pro Glu Val Leu Asp 
        195                 200                 205             


Glu Gln Ile Arg Xaa Asp Cys Phe Glu Ser Tyr Lys Trp Xaa Asp Ile 
    210                 215                 220                 


Trp Ala Phe Gly Leu Val Leu Trp Glu Ile Ala Arg Arg Xaa Ile Val 
225                 230                 235                 240 


Asn Gly Ile Val Glu Asp Tyr Arg Pro Pro Phe Tyr Asp Val Val Pro 
                245                 250                 255     


Asn Asp Pro Ser Phe Glu Asp Met Lys Lys Val Val Cys Val Asp Gln 
            260                 265                 270         


Gln Xaa Pro Xaa Ile Pro Asn Arg Leu Ala Ala Asp Pro Val Leu Ser 
        275                 280                 285             


Gly Leu Ala Gln Met Met Arg Glu Cys Trp Tyr Pro Asn Pro Ser Ala 
    290                 295                 300                 


Arg Leu Xaa Ala Leu Arg Ile Lys Lys Xaa Leu Gln Lys Ile Ser Asn 
305                 310                 315                 320 


Ser Pro Glu Lys Pro Lys Val Ile Gln 
                325                 


<210> 1453
<211> 89
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<400> 1453
Met Xaa Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala 
1               5                   10                  15      


Leu Val Xaa Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro Leu Val 
            20                  25                  30          


Xaa Cys Xaa Cys Glu Ser Pro His Cys Lys Gly Pro Xaa Cys Arg Gly 
        35                  40                  45              


Ala Trp Cys Xaa Val Val Leu Val Arg Glu Glu Gly Arg His Pro Gln 
    50                  55                  60                  


Glu His Arg Gly Cys Gly Asn Leu His Arg Glu Leu Cys Arg Gly Arg 
65                  70                  75                  80  


Pro Xaa Glu Phe Val Asn His Tyr Cys 
                85                  


<210> 1454
<211> 503
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<400> 1454
Met Xaa Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala 
1               5                   10                  15      


Leu Val Xaa Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro Leu Val 
            20                  25                  30          


Xaa Cys Xaa Cys Glu Ser Pro His Cys Lys Gly Pro Xaa Cys Arg Gly 
        35                  40                  45              


Ala Trp Cys Xaa Val Val Leu Val Arg Glu Glu Gly Arg His Pro Gln 
    50                  55                  60                  


Glu His Arg Gly Cys Gly Asn Leu His Arg Glu Leu Cys Arg Gly Arg 
65                  70                  75                  80  


Pro Xaa Glu Phe Val Asn His Tyr Cys Cys Asp Ser His Leu Cys Asn 
                85                  90                  95      


His Asn Val Ser Leu Val Leu Glu Ala Xaa Gln Pro Pro Ser Glu Gln 
            100                 105                 110         


Pro Gly Xaa Asp Gly Gln Leu Ala Leu Ile Leu Gly Pro Val Leu Ala 
        115                 120                 125             


Leu Leu Ala Leu Val Ala Leu Gly Val Leu Gly Leu Trp His Val Arg 
    130                 135                 140                 


Arg Arg Gln Glu Lys Gln Arg Gly Leu His Ser Glu Leu Gly Glu Ser 
145                 150                 155                 160 


Ser Leu Ile Leu Lys Ala Ser Glu Gln Gly Asp Ser Met Leu Gly Asp 
                165                 170                 175     


Leu Leu Asp Ser Asp Cys Xaa Xaa Gly Ser Gly Ser Gly Leu Pro Phe 
            180                 185                 190         


Leu Val Gln Arg Xaa Val Ala Arg Gln Val Ala Leu Val Glu Cys Val 
        195                 200                 205             


Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg Gly Leu Trp His Gly Glu 
    210                 215                 220                 


Ser Val Ala Val Lys Ile Phe Ser Ser Arg Asp Glu Gln Ser Trp Phe 
225                 230                 235                 240 


Arg Glu Xaa Glu Ile Tyr Asn Xaa Val Leu Leu Arg His Asp Asn Ile 
                245                 250                 255     


Leu Gly Phe Ile Ala Ser Asp Met Xaa Ser Arg Asn Ser Ser Xaa Gln 
            260                 265                 270         


Leu Trp Leu Ile Xaa His Tyr His Glu His Gly Ser Leu Tyr Asp Phe 
        275                 280                 285             


Leu Gln Arg Gln Xaa Leu Glu Pro His Leu Ala Leu Arg Leu Ala Val 
    290                 295                 300                 


Ser Ala Ala Cys Gly Leu Ala His Leu His Val Glu Ile Phe Gly Xaa 
305                 310                 315                 320 


Gln Gly Lys Pro Ala Ile Ala His Arg Asp Phe Lys Ser Arg Asn Val 
                325                 330                 335     


Leu Val Lys Ser Asn Leu Gln Cys Cys Ile Ala Asp Leu Gly Leu Ala 
            340                 345                 350         


Val Met His Ser Gln Gly Ser Asp Tyr Leu Asp Ile Gly Asn Asn Pro 
        355                 360                 365             


Arg Val Gly Xaa Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Gln 
    370                 375                 380                 


Ile Arg Xaa Asp Cys Phe Glu Ser Tyr Lys Trp Xaa Asp Ile Trp Ala 
385                 390                 395                 400 


Phe Gly Leu Val Leu Trp Glu Ile Ala Arg Arg Xaa Ile Val Asn Gly 
                405                 410                 415     


Ile Val Glu Asp Tyr Arg Pro Pro Phe Tyr Asp Val Val Pro Asn Asp 
            420                 425                 430         


Pro Ser Phe Glu Asp Met Lys Lys Val Val Cys Val Asp Gln Gln Xaa 
        435                 440                 445             


Pro Xaa Ile Pro Asn Arg Leu Ala Ala Asp Pro Val Leu Ser Gly Leu 
    450                 455                 460                 


Ala Gln Met Met Arg Glu Cys Trp Tyr Pro Asn Pro Ser Ala Arg Leu 
465                 470                 475                 480 


Xaa Ala Leu Arg Ile Lys Lys Xaa Leu Gln Lys Ile Ser Asn Ser Pro 
                485                 490                 495     


Glu Lys Pro Lys Val Ile Gln 
            500             


<210> 1455
<211> 163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<400> 1455
Xaa Ser Arg Asn Val Leu Val Lys Ser Asn Leu Gln Cys Cys Ile Ala 
1               5                   10                  15      


Asp Leu Gly Leu Ala Val Met His Ser Gln Gly Ser Asp Tyr Leu Asp 
            20                  25                  30          


Ile Gly Asn Asn Pro Arg Val Gly Xaa Lys Arg Tyr Met Ala Pro Glu 
        35                  40                  45              


Val Leu Asp Glu Gln Ile Arg Xaa Asp Cys Phe Glu Ser Tyr Lys Trp 
    50                  55                  60                  


Xaa Asp Ile Trp Ala Phe Gly Leu Val Leu Trp Glu Ile Ala Arg Arg 
65                  70                  75                  80  


Xaa Ile Val Asn Gly Ile Val Glu Asp Tyr Arg Pro Pro Phe Tyr Asp 
                85                  90                  95      


Val Val Pro Asn Asp Pro Ser Phe Glu Asp Met Lys Lys Val Val Cys 
            100                 105                 110         


Val Asp Gln Gln Xaa Pro Xaa Ile Pro Asn Arg Leu Ala Ala Asp Pro 
        115                 120                 125             


Val Arg Pro Leu Leu Gly Leu Gly Trp Arg Gly Val Val Ala His Gly 
    130                 135                 140                 


Trp Asp Phe Trp Ala Gln Glu Leu Val Ser Glu Ala Ser Ala Ser Ser 
145                 150                 155                 160 


His Arg Tyr 
            


<210> 1456
<211> 339
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<400> 1456
Met Ala Gln Xaa Pro Ala Phe Asp Lys Pro Lys Val Glu Leu His Val 
1               5                   10                  15      


His Leu Asp Gly Ser Ile Lys Pro Glu Xaa Ile Leu Tyr Tyr Gly Arg 
            20                  25                  30          


Arg Arg Gly Ile Ala Leu Pro Ala Asn Xaa Ala Glu Gly Leu Leu Asn 
        35                  40                  45              


Val Ile Gly Met Asp Lys Pro Leu Xaa Leu Pro Asp Phe Leu Ala Lys 
    50                  55                  60                  


Phe Asp Tyr Tyr Met Pro Ala Ile Ala Gly Cys Arg Glu Ala Ile Lys 
65                  70                  75                  80  


Arg Ile Ala Tyr Glu Phe Val Glu Met Lys Ala Lys Glu Gly Val Val 
                85                  90                  95      


Tyr Val Glu Val Arg Tyr Ser Pro His Leu Leu Ala Asn Ser Lys Val 
            100                 105                 110         


Glu Pro Ile Pro Trp Asn Gln Ala Glu Gly Asp Leu Xaa Pro Asp Glu 
        115                 120                 125             


Val Val Ala Leu Val Gly Gln Gly Leu Gln Glu Gly Glu Arg Asp Phe 
    130                 135                 140                 


Gly Val Lys Ala Arg Ser Ile Leu Cys Cys Met Arg His Gln Pro Asn 
145                 150                 155                 160 


Trp Ser Pro Lys Val Val Glu Leu Cys Lys Lys Tyr Gln Gln Gln Xaa 
                165                 170                 175     


Val Val Ala Ile Asp Leu Ala Gly Asp Glu Xaa Ile Pro Gly Ser Ser 
            180                 185                 190         


Leu Leu Pro Gly His Val Gln Ala Tyr Gln Ala Val Asp Ile Leu Lys 
        195                 200                 205             


Xaa Glu Arg Leu Gly His Gly Tyr His Xaa Leu Glu Asp Gln Ala Leu 
    210                 215                 220                 


Tyr Asn Arg Leu Arg Gln Glu Asn Met His Phe Glu Ile Cys Pro Trp 
225                 230                 235                 240 


Ser Ser Tyr Leu Xaa Gly Ala Trp Lys Pro Asp Xaa Glu His Ala Val 
                245                 250                 255     


Ile Arg Leu Lys Asn Asp Gln Ala Asn Tyr Ser Leu Asn Xaa Asp Asp 
            260                 265                 270         


Pro Leu Ile Phe Lys Ser Xaa Leu Asp Xaa Asp Tyr Gln Met Xaa Lys 
        275                 280                 285             


Arg Asp Met Gly Phe Xaa Glu Glu Glu Phe Lys Arg Leu Asn Ile Asn 
    290                 295                 300                 


Ala Ala Lys Ser Ser Phe Leu Pro Glu Asp Glu Lys Arg Glu Leu Leu 
305                 310                 315                 320 


Asp Leu Leu Tyr Lys Ala Tyr Gly Met Pro Pro Ser Ala Ser Ala Gly 
                325                 330                 335     


Gln Asn Leu 
            


<210> 1457
<211> 263
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<400> 1457
Met Ala Gln Xaa Pro Ala Phe Asp Lys Pro Lys Val Glu Leu His Val 
1               5                   10                  15      


His Leu Asp Gly Ser Ile Lys Pro Glu Xaa Ile Leu Tyr Tyr Gly Arg 
            20                  25                  30          


Arg Arg Gly Ile Ala Leu Pro Ala Asn Xaa Ala Glu Gly Leu Leu Asn 
        35                  40                  45              


Val Ile Gly Met Asp Lys Pro Leu Xaa Leu Pro Asp Phe Leu Ala Lys 
    50                  55                  60                  


Phe Asp Tyr Tyr Met Pro Ala Ile Ala Gly Cys Arg Glu Ala Ile Lys 
65                  70                  75                  80  


Arg Ile Ala Tyr Glu Phe Val Glu Met Lys Ala Lys Glu Gly Val Val 
                85                  90                  95      


Tyr Val Glu Val Arg Tyr Ser Pro His Leu Leu Ala Asn Ser Lys Val 
            100                 105                 110         


Glu Pro Ile Pro Trp Asn Gln Ala Glu Gly Asp Leu Xaa Pro Asp Glu 
        115                 120                 125             


Val Val Ala Leu Val Gly Gln Gly Leu Gln Glu Gly Glu Arg Asp Phe 
    130                 135                 140                 


Gly Val Lys Ala Arg Ser Ile Leu Cys Cys Met Arg His Gln Pro Asn 
145                 150                 155                 160 


Trp Ser Pro Lys Val Val Glu Leu Cys Lys Lys Tyr Gln Gln Gln Xaa 
                165                 170                 175     


Val Val Ala Ile Asp Leu Ala Gly Asp Glu Xaa Ile Pro Gly Ser Ser 
            180                 185                 190         


Leu Leu Pro Gly His Val Gln Ala Tyr Gln Glu Ala Val Lys Ser Gly 
        195                 200                 205             


Ile His Arg Xaa Val His Ala Gly Glu Val Gly Ser Ala Glu Val Val 
    210                 215                 220                 


Lys Glu Ala Val Asp Ile Leu Lys Xaa Glu Arg Leu Gly His Gly Tyr 
225                 230                 235                 240 


His Xaa Leu Glu Asp Gln Ala Leu Tyr Asn Arg Leu Arg Gln Glu Asn 
                245                 250                 255     


Met His Phe Glu Ala Gln Lys 
            260             


<210> 1458
<211> 363
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<400> 1458
Met Ala Gln Xaa Pro Ala Phe Asp Lys Pro Lys Val Glu Leu His Val 
1               5                   10                  15      


His Leu Asp Gly Ser Ile Lys Pro Glu Xaa Ile Leu Tyr Tyr Gly Arg 
            20                  25                  30          


Arg Arg Gly Ile Ala Leu Pro Ala Asn Xaa Ala Glu Gly Leu Leu Asn 
        35                  40                  45              


Val Ile Gly Met Asp Lys Pro Leu Xaa Leu Pro Asp Phe Leu Ala Lys 
    50                  55                  60                  


Phe Asp Tyr Tyr Met Pro Ala Ile Ala Gly Cys Arg Glu Ala Ile Lys 
65                  70                  75                  80  


Arg Ile Ala Tyr Glu Phe Val Glu Met Lys Ala Lys Glu Gly Val Val 
                85                  90                  95      


Tyr Val Glu Val Arg Tyr Ser Pro His Leu Leu Ala Asn Ser Lys Val 
            100                 105                 110         


Glu Pro Ile Pro Trp Asn Gln Ala Glu Gly Asp Leu Xaa Pro Asp Glu 
        115                 120                 125             


Val Val Ala Leu Val Gly Gln Gly Leu Gln Glu Gly Glu Arg Asp Phe 
    130                 135                 140                 


Gly Val Lys Ala Arg Ser Ile Leu Cys Cys Met Arg His Gln Pro Asn 
145                 150                 155                 160 


Trp Ser Pro Lys Val Val Glu Leu Cys Lys Lys Tyr Gln Gln Gln Xaa 
                165                 170                 175     


Val Val Ala Ile Asp Leu Ala Gly Asp Glu Xaa Ile Pro Gly Ser Ser 
            180                 185                 190         


Leu Leu Pro Gly His Val Gln Ala Tyr Gln Glu Ala Val Lys Ser Gly 
        195                 200                 205             


Ile His Arg Xaa Val His Ala Gly Glu Val Gly Ser Ala Glu Val Val 
    210                 215                 220                 


Lys Glu Ala Val Asp Ile Leu Lys Xaa Glu Arg Leu Gly His Gly Tyr 
225                 230                 235                 240 


His Xaa Leu Glu Asp Gln Ala Leu Tyr Asn Arg Leu Arg Gln Glu Asn 
                245                 250                 255     


Met His Phe Glu Ile Cys Pro Trp Ser Ser Tyr Leu Xaa Gly Ala Trp 
            260                 265                 270         


Lys Pro Asp Xaa Glu His Ala Val Ile Arg Leu Lys Asn Asp Gln Ala 
        275                 280                 285             


Asn Tyr Ser Leu Asn Xaa Asp Asp Pro Leu Ile Phe Lys Ser Xaa Leu 
    290                 295                 300                 


Asp Xaa Asp Tyr Gln Met Xaa Lys Arg Asp Met Gly Phe Xaa Glu Glu 
305                 310                 315                 320 


Glu Phe Lys Arg Leu Asn Ile Asn Ala Ala Lys Ser Ser Phe Leu Pro 
                325                 330                 335     


Glu Asp Glu Lys Arg Glu Leu Leu Asp Leu Leu Tyr Lys Ala Tyr Gly 
            340                 345                 350         


Met Pro Pro Ser Ala Ser Ala Gly Gln Asn Leu 
        355                 360             


<210> 1459
<211> 75
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<400> 1459
Met Ala Gln Xaa Pro Ala Phe Asp Lys Pro Lys Val Glu Leu His Val 
1               5                   10                  15      


His Leu Asp Gly Ser Ile Lys Pro Glu Xaa Ile Leu Tyr Tyr Gly Arg 
            20                  25                  30          


Arg Arg Gly Ile Ala Leu Pro Ala Asn Xaa Ala Glu Gly Leu Leu Asn 
        35                  40                  45              


Val Ile Gly Met Asp Lys Pro Leu Xaa Leu Pro Asp Phe Leu Ala Lys 
    50                  55                  60                  


Phe Asp Tyr Tyr Met Pro Ala Ile Ala Arg Leu 
65                  70                  75  


<210> 1460
<211> 59
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<400> 1460
Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Ala Pro Ala Arg Trp Arg Ile Pro Lys Ser Ser Pro Pro Pro 
            20                  25                  30          


Arg Pro Ala Ala Gln Xaa Arg Gly Lys Leu Cys Cys Leu Gln Leu Gly 
        35                  40                  45              


Ser Cys Ile Val Leu Tyr Pro Ala Arg Arg Ser 
    50                  55                  


<210> 1461
<211> 148
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<400> 1461
Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Asp Arg Asp Phe Asp Asp Gly Val Leu Gly Leu Ala Trp Val 
            20                  25                  30          


Gly Ala Pro Ser Gly Ser Ser Gly Gly Ile Cys Glu Lys Ser Lys Leu 
        35                  40                  45              


Tyr Ser Asp Gly Lys Lys Lys Ser Leu Asn Xaa Gly Ile Ile Xaa Val 
    50                  55                  60                  


Gln Asn Tyr Gly Ser His Val Pro Pro Lys Val Ser His Ile Xaa Phe 
65                  70                  75                  80  


Ala His Glu Val Gly His Asn Phe Gly Ser Pro His Asp Ser Gly Xaa 
                85                  90                  95      


Glu Cys Xaa Pro Gly Glu Ser Lys Asn Leu Gly Gln Lys Glu Asn Gly 
            100                 105                 110         


Asn Tyr Ile Met Tyr Ala Arg Ala Xaa Ser Gly Asp Lys Leu Asn Asn 
        115                 120                 125             


Asn Lys Phe Ser Leu Cys Ser Ile Arg Asn Ile Ser Gln Val Leu Glu 
    130                 135                 140                 


Lys Lys Arg Asn 
145             


<210> 1462
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<400> 1462
Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Asp Arg Asp Phe Asp Asp Gly Val Leu Gly Leu Ala Trp Val 
            20                  25                  30          


Gly Ala Pro Ser Gly Ser Ser Gly Gly Ile Cys Glu Lys Ser Lys Leu 
        35                  40                  45              


Tyr Ser Asp Val Pro Xaa Met Gly Lys Leu His Ser Lys Glu Lys Pro 
    50                  55                  60                  


Ile Lys Ser Ser Ser Pro Asn 
65                  70      


<210> 1463
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 1463
Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Gly Gln Tyr Gly Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr 
            20                  25                  30          


Glu Gly Leu Ser Tyr Asn Val Asp Ser Leu His Gln Lys His Gln Arg 
        35                  40                  45              


Ala Lys Arg Ala Val Ser His Glu Asp Gln Phe Leu Arg Leu Asp Phe 
    50                  55                  60                  


His Ala His Gly Arg Asp Gly Val Leu Pro Cys Cys Pro Gly Trp Ser 
65                  70                  75                  80  


Gln Xaa Pro Gly Leu Lys Arg Ser Xaa Cys Leu Ser Leu Pro Gln Cys 
                85                  90                  95      


Trp Asp Tyr Arg Cys Glu Pro Ser Pro Met Ile Ser Val Phe Asp Tyr 
            100                 105                 110         


Pro His Lys 
        115 


<210> 1464
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<400> 1464
Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Gly Gln Tyr Gly Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr 
            20                  25                  30          


Glu Gly Leu Ser Tyr Asn Val Asp Ser Leu His Gln Lys His Gln Arg 
        35                  40                  45              


Ala Lys Arg Ala Val Ser His Glu Asp Gln Phe Leu Arg Leu Asp Phe 
    50                  55                  60                  


His Ala His Gly Arg His Phe Asn Leu Arg Met Lys Arg Asp Xaa Ser 
65                  70                  75                  80  


Leu Phe Ser Asp Glu Phe Lys Val Glu Xaa Ser Asn Lys Val Leu Asp 
                85                  90                  95      


Tyr Asp Xaa Ser His Ile Tyr Xaa Gly His Ile Tyr Asp Tyr Pro His 
            100                 105                 110         


Lys Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val 
        115                 120                 125 


<210> 1465
<211> 748
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<400> 1465
Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Gly Gln Tyr Gly Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr 
            20                  25                  30          


Glu Gly Leu Ser Tyr Asn Val Asp Ser Leu His Gln Lys His Gln Arg 
        35                  40                  45              


Ala Lys Arg Ala Val Ser His Glu Asp Gln Phe Leu Arg Leu Asp Phe 
    50                  55                  60                  


His Ala His Gly Arg His Phe Asn Leu Arg Met Lys Arg Asp Xaa Ser 
65                  70                  75                  80  


Leu Phe Ser Asp Glu Phe Lys Val Glu Xaa Ser Asn Lys Val Leu Asp 
                85                  90                  95      


Tyr Asp Xaa Ser His Ile Tyr Xaa Gly His Ile Tyr Gly Glu Glu Gly 
            100                 105                 110         


Ser Phe Ser His Gly Ser Val Ile Asp Gly Arg Phe Glu Gly Phe Ile 
        115                 120                 125             


Gln Xaa Arg Gly Gly Xaa Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile 
    130                 135                 140                 


Lys Asp Arg Xaa Leu Pro Phe His Ser Val Ile Tyr His Glu Asp Asp 
145                 150                 155                 160 


Ile Asn Tyr Pro His Lys Tyr Gly Pro Gln Gly Gly Cys Ala Asp His 
                165                 170                 175     


Ser Val Phe Glu Arg Met Arg Lys Tyr Gln Met Xaa Gly Val Glu Glu 
            180                 185                 190         


Val Xaa Gln Ile Pro Gln Glu Glu His Ala Ala Asn Gly Pro Glu Leu 
        195                 200                 205             


Leu Arg Lys Lys Arg Xaa Xaa Ser Ala Glu Lys Asn Xaa Cys Gln Leu 
    210                 215                 220                 


Tyr Ile Gln Xaa Asp His Leu Phe Phe Lys Tyr Tyr Gly Xaa Arg Glu 
225                 230                 235                 240 


Ala Val Ile Ala Gln Ile Ser Ser His Val Lys Ala Ile Asp Xaa Ile 
                245                 250                 255     


Tyr Gln Xaa Xaa Asp Phe Ser Gly Ile Arg Asn Ile Ser Phe Met Val 
            260                 265                 270         


Lys Arg Ile Arg Ile Asn Xaa Xaa Ala Asp Glu Lys Asp Pro Xaa Asn 
        275                 280                 285             


Pro Phe Arg Phe Pro Asn Ile Gly Val Glu Lys Phe Leu Glu Leu Asn 
    290                 295                 300                 


Ser Glu Gln Asn His Asp Asp Tyr Cys Leu Ala Tyr Val Phe Xaa Asp 
305                 310                 315                 320 


Arg Asp Phe Asp Asp Gly Val Leu Gly Leu Ala Trp Val Gly Ala Pro 
                325                 330                 335     


Ser Gly Ser Ser Gly Gly Ile Cys Glu Lys Ser Lys Leu Tyr Ser Asp 
            340                 345                 350         


Gly Lys Lys Lys Ser Leu Asn Xaa Gly Ile Ile Xaa Val Gln Asn Tyr 
        355                 360                 365             


Gly Ser His Val Pro Pro Lys Val Ser His Ile Xaa Phe Ala His Glu 
    370                 375                 380                 


Val Gly His Asn Phe Gly Ser Pro His Asp Ser Gly Xaa Glu Cys Xaa 
385                 390                 395                 400 


Pro Gly Glu Ser Lys Asn Leu Gly Gln Lys Glu Asn Gly Asn Tyr Ile 
                405                 410                 415     


Met Tyr Ala Arg Ala Xaa Ser Gly Asp Lys Leu Asn Asn Asn Lys Phe 
            420                 425                 430         


Ser Leu Cys Ser Ile Arg Asn Ile Ser Gln Val Leu Glu Lys Lys Arg 
        435                 440                 445             


Asn Asn Cys Phe Val Glu Ser Gly Gln Pro Ile Cys Gly Asn Gly Met 
    450                 455                 460                 


Val Glu Gln Gly Glu Glu Cys Asp Cys Gly Tyr Ser Asp Gln Cys Lys 
465                 470                 475                 480 


Asp Glu Cys Cys Phe Asp Ala Asn Gln Pro Glu Gly Arg Lys Cys Lys 
                485                 490                 495     


Leu Lys Pro Gly Lys Gln Cys Ser Pro Ser Gln Gly Pro Cys Cys Xaa 
            500                 505                 510         


Ala Gln Cys Ala Phe Lys Ser Lys Ser Glu Lys Cys Arg Asp Asp Ser 
        515                 520                 525             


Asp Cys Ala Arg Glu Gly Ile Cys Asn Gly Phe Xaa Ala Leu Cys Pro 
    530                 535                 540                 


Ala Ser Asp Pro Lys Pro Asn Phe Xaa Asp Cys Asn Arg His Xaa Gln 
545                 550                 555                 560 


Val Cys Ile Asn Gly Gln Cys Ala Gly Ser Ile Cys Glu Lys Tyr Gly 
                565                 570                 575     


Leu Glu Glu Cys Xaa Cys Ala Ser Ser Asp Gly Lys Asp Asp Lys Glu 
            580                 585                 590         


Leu Cys His Val Cys Cys Met Lys Lys Met Asp Pro Ser Xaa Cys Ala 
        595                 600                 605             


Ser Xaa Gly Ser Val Gln Trp Ser Arg His Phe Ser Gly Arg Xaa Ile 
    610                 615                 620                 


Xaa Leu Gln Pro Gly Ser Pro Cys Asn Asp Phe Arg Gly Tyr Cys Asp 
625                 630                 635                 640 


Val Phe Met Arg Cys Arg Leu Val Asp Ala Asp Gly Pro Leu Ala Arg 
                645                 650                 655     


Leu Lys Lys Ala Ile Phe Ser Pro Glu Leu Tyr Glu Asn Ile Ala Glu 
            660                 665                 670         


Trp Ile Val Ala His Trp Trp Ala Val Leu Leu Met Gly Ile Ala Leu 
        675                 680                 685             


Ile Met Leu Met Ala Gly Phe Ile Lys Ile Cys Ser Val His Xaa Pro 
    690                 695                 700                 


Ser Ser Asn Pro Lys Leu Pro Pro Pro Lys Pro Leu Pro Gly Xaa Leu 
705                 710                 715                 720 


Lys Arg Arg Arg Pro Pro Gln Pro Ile Gln Gln Pro Gln Arg Gln Arg 
                725                 730                 735     


Pro Arg Glu Ser Tyr Gln Met Gly His Met Arg Arg 
            740                 745             


<210> 1466
<211> 38
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<400> 1466
Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Val Pro Xaa Met Gly Lys Leu His Ser Lys Glu Lys Pro Ile 
            20                  25                  30          


Lys Ser Ser Ser Pro Asn 
        35              


<210> 1467
<211> 58
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<400> 1467
Xaa Glu Glu Gly Ser Phe Ser His Gly Ser Val Ile Asp Gly Arg Phe 
1               5                   10                  15      


Glu Gly Phe Ile Gln Xaa Arg Gly Gly Xaa Phe Tyr Val Glu Pro Ala 
            20                  25                  30          


Glu Arg Tyr Ile Lys Asp Arg Xaa Leu Pro Phe His Ser Val Ile Tyr 
        35                  40                  45              


His Glu Asp Asp Ile Ser Glu Gly Leu Asn 
    50                  55              


<210> 1468
<211> 517
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<400> 1468
Leu Leu Ser Ser Gln Tyr Val Glu Arg His Phe Ser Arg Glu Gly Xaa 
1               5                   10                  15      


Xaa Gln His Ser Xaa Gly Ala Gly Asp His Cys Tyr Tyr Gln Gly Lys 
            20                  25                  30          


Leu Arg Gly Asn Pro His Ser Phe Ala Ala Leu Ser Xaa Cys Gln Gly 
        35                  40                  45              


Leu His Gly Val Phe Ser Asp Gly Asn Leu Xaa Tyr Ile Val Glu Pro 
    50                  55                  60                  


Gln Glu Val Ala Gly Pro Trp Gly Ala Pro Gln Gly Pro Leu Pro His 
65                  70                  75                  80  


Leu Ile Tyr Arg Xaa Pro Leu Leu Pro Asp Pro Leu Gly Cys Arg Glu 
                85                  90                  95      


Pro Gly Cys Leu Phe Ala Val Pro Ala Gln Ser Ala Pro Pro Asn Arg 
            100                 105                 110         


Pro Arg Leu Arg Arg Lys Arg Gln Val Arg Arg Gly His Pro Xaa Val 
        115                 120                 125             


His Ser Glu Xaa Lys Tyr Val Glu Leu Ile Val Ile Asn Asp His Gln 
    130                 135                 140                 


Leu Phe Glu Gln Met Arg Gln Ser Val Val Leu Xaa Ser Asn Phe Ala 
145                 150                 155                 160 


Lys Ser Val Val Asn Leu Ala Asp Val Ile Tyr Lys Glu Gln Leu Asn 
                165                 170                 175     


Xaa Arg Ile Val Leu Val Ala Met Glu Xaa Trp Ala Asp Gly Asp Lys 
            180                 185                 190         


Ile Gln Val Gln Asp Asp Leu Leu Glu Xaa Leu Ala Arg Leu Met Val 
        195                 200                 205             


Tyr Arg Arg Glu Gly Leu Pro Glu Pro Ser Asp Ala Xaa His Leu Phe 
    210                 215                 220                 


Ser Gly Arg Xaa Phe Gln Ser Xaa Ser Ser Gly Ala Ala Tyr Val Gly 
225                 230                 235                 240 


Gly Ile Cys Ser Leu Ser His Gly Gly Gly Val Asn Glu Tyr Gly Asn 
                245                 250                 255     


Met Gly Ala Met Ala Val Xaa Leu Ala Gln Xaa Leu Gly Gln Asn Leu 
            260                 265                 270         


Gly Met Met Trp Asn Lys His Arg Ser Ser Ala Gly Asp Cys Lys Cys 
        275                 280                 285             


Pro Asp Ile Trp Leu Gly Cys Ile Met Glu Asp Xaa Gly Phe Tyr Leu 
    290                 295                 300                 


Pro Arg Lys Phe Ser Arg Cys Ser Ile Asp Glu Tyr Asn Gln Phe Leu 
305                 310                 315                 320 


Gln Glu Gly Gly Gly Ser Cys Leu Phe Asn Lys Pro Leu Lys Leu Leu 
                325                 330                 335     


Asp Pro Pro Glu Cys Gly Asn Gly Phe Val Glu Ala Gly Glu Glu Cys 
            340                 345                 350         


Asp Cys Gly Ser Val Gln Glu Cys Ser Arg Ala Gly Gly Asn Cys Cys 
        355                 360                 365             


Lys Lys Cys Xaa Leu Xaa His Asp Ala Met Cys Ser Asp Gly Leu Cys 
    370                 375                 380                 


Cys Arg Arg Cys Lys Tyr Glu Pro Arg Gly Val Ser Cys Arg Glu Ala 
385                 390                 395                 400 


Val Asn Glu Cys Asp Ile Ala Glu Xaa Cys Xaa Gly Asp Ser Ser Gln 
                405                 410                 415     


Cys Pro Pro Asn Leu His Lys Leu Asp Gly Tyr Tyr Cys Asp His Glu 
            420                 425                 430         


Gln Gly Arg Cys Tyr Gly Gly Arg Cys Lys Xaa Arg Asp Arg Gln Cys 
        435                 440                 445             


Gln Val Leu Trp Gly His Ala Ala Ala Asp Arg Phe Cys Tyr Glu Lys 
    450                 455                 460                 


Leu Asn Val Glu Gly Xaa Glu Arg Gly Ser Cys Gly Arg Lys Gly Ser 
465                 470                 475                 480 


Gly Trp Val Gln Cys Ser Lys Gln Pro Gln Gln Gly Arg Ala Val Trp 
                485                 490                 495     


Leu Pro Pro Leu Cys Gln His Leu Trp Ser Ser Ser Ala Arg Gly Pro 
            500                 505                 510         


Gly Gly Arg His Gln 
        515         


<210> 1469
<211> 569
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<400> 1469
Met Gln Gly Xaa Arg Leu Pro Val Cys Cys Ala Cys Pro Val Gly Ser 
1               5                   10                  15      


Ser Lys Pro Ala Glu Ala Glu Lys Glu Lys Val Arg Arg Gly His Pro 
            20                  25                  30          


Xaa Val His Ser Glu Xaa Lys Tyr Val Glu Leu Ile Val Ile Asn Asp 
        35                  40                  45              


His Gln Leu Phe Glu Gln Met Arg Gln Ser Val Val Leu Xaa Ser Asn 
    50                  55                  60                  


Phe Ala Lys Ser Val Val Asn Leu Ala Asp Val Ile Tyr Lys Glu Gln 
65                  70                  75                  80  


Leu Asn Xaa Arg Ile Val Leu Val Ala Met Glu Xaa Trp Ala Asp Gly 
                85                  90                  95      


Asp Lys Ile Gln Val Gln Asp Asp Leu Leu Glu Xaa Leu Ala Arg Leu 
            100                 105                 110         


Met Val Tyr Arg Arg Glu Gly Leu Pro Glu Pro Ser Asp Ala Xaa His 
        115                 120                 125             


Leu Phe Ser Gly Arg Xaa Phe Gln Ser Xaa Ser Ser Gly Ala Ala Tyr 
    130                 135                 140                 


Val Gly Gly Ile Cys Ser Leu Ser His Gly Gly Gly Val Asn Glu Tyr 
145                 150                 155                 160 


Gly Asn Met Gly Ala Met Ala Val Xaa Leu Ala Gln Xaa Leu Gly Gln 
                165                 170                 175     


Asn Leu Gly Met Met Trp Asn Lys His Arg Ser Ser Ala Gly Asp Cys 
            180                 185                 190         


Lys Cys Pro Asp Ile Trp Leu Gly Cys Ile Met Glu Asp Xaa Gly Phe 
        195                 200                 205             


Tyr Leu Pro Arg Lys Phe Ser Arg Cys Ser Ile Asp Glu Tyr Asn Gln 
    210                 215                 220                 


Phe Leu Gln Glu Gly Gly Gly Ser Cys Leu Phe Asn Lys Pro Leu Lys 
225                 230                 235                 240 


Leu Leu Asp Pro Pro Glu Cys Gly Asn Gly Phe Val Glu Ala Gly Glu 
                245                 250                 255     


Glu Cys Asp Cys Gly Ser Val Gln Glu Cys Ser Arg Ala Gly Gly Asn 
            260                 265                 270         


Cys Cys Lys Lys Cys Xaa Leu Xaa His Asp Ala Met Cys Ser Asp Gly 
        275                 280                 285             


Leu Cys Cys Arg Arg Cys Lys Tyr Glu Pro Arg Gly Val Ser Cys Arg 
    290                 295                 300                 


Glu Ala Val Asn Glu Cys Asp Ile Ala Glu Xaa Cys Xaa Gly Asp Ser 
305                 310                 315                 320 


Ser Gln Cys Pro Pro Asn Leu His Lys Leu Asp Gly Tyr Tyr Cys Asp 
                325                 330                 335     


His Glu Gln Gly Arg Cys Tyr Gly Gly Arg Cys Lys Xaa Arg Asp Arg 
            340                 345                 350         


Gln Cys Gln Val Leu Trp Gly His Ala Ala Ala Asp Arg Phe Cys Tyr 
        355                 360                 365             


Glu Lys Leu Asn Val Glu Gly Xaa Glu Arg Gly Ser Cys Gly Arg Lys 
    370                 375                 380                 


Gly Ser Gly Trp Val Gln Cys Ser Lys Gln Asp Val Leu Cys Gly Phe 
385                 390                 395                 400 


Leu Leu Cys Val Asn Ile Ser Gly Ala Pro Arg Leu Gly Asp Leu Val 
                405                 410                 415     


Gly Asp Ile Ser Ser Val Xaa Phe Tyr His Gln Gly Lys Glu Leu Asp 
            420                 425                 430         


Cys Arg Gly Gly His Val Gln Leu Ala Asp Gly Ser Asp Leu Ser Tyr 
        435                 440                 445             


Val Glu Asp Gly Xaa Ala Cys Gly Pro Asn Met Leu Cys Leu Asp His 
    450                 455                 460                 


Arg Cys Leu Pro Ala Ser Ala Phe Asn Phe Ser Xaa Cys Pro Gly Ser 
465                 470                 475                 480 


Gly Glu Arg Arg Ile Cys Ser His His Gly Val Cys Ser Asn Glu Gly 
                485                 490                 495     


Lys Cys Ile Cys Gln Pro Asp Trp Xaa Gly Lys Asp Cys Ser Ile His 
            500                 505                 510         


Asn Pro Leu Pro Xaa Ser Pro Pro Xaa Gly Glu Xaa Glu Arg Tyr Lys 
        515                 520                 525             


Gly Pro Ser Gly Xaa Asn Ile Ile Ile Gly Ser Ile Ala Gly Ala Val 
    530                 535                 540                 


Leu Val Ala Ala Ile Val Leu Gly Gly Xaa Gly Trp Gly Phe Lys Asn 
545                 550                 555                 560 


Ile Arg Arg Gly Arg Ser Gly Gly Ala 
                565                 


<210> 1470
<211> 769
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<400> 1470
Met Arg Leu Leu Arg Arg Trp Ala Phe Ala Ala Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Pro Xaa Pro Gly Leu Gly Xaa Gln Gly Pro Ala Gly Ala Leu Arg 
            20                  25                  30          


Trp Gly Gly Leu Pro Gln Leu Gly Gly Pro Gly Ala Pro Glu Val Xaa 
        35                  40                  45              


Glu Pro Ser Arg Leu Val Arg Glu Ser Ser Gly Gly Glu Val Arg Lys 
    50                  55                  60                  


Gln Gln Leu Asp Xaa Arg Val Arg Gln Glu Pro Pro Gly Gly Pro Pro 
65                  70                  75                  80  


Val His Leu Ala Gln Val Ser Phe Val Ile Pro Ala Phe Asn Ser Asn 
                85                  90                  95      


Phe Xaa Leu Asp Leu Glu Leu Asn His His Leu Leu Ser Ser Gln Tyr 
            100                 105                 110         


Val Glu Arg His Phe Ser Arg Glu Gly Xaa Xaa Gln His Ser Xaa Gly 
        115                 120                 125             


Ala Gly Asp His Cys Tyr Tyr Gln Gly Lys Leu Arg Gly Asn Pro His 
    130                 135                 140                 


Ser Phe Ala Ala Leu Ser Xaa Cys Gln Gly Leu His Gly Val Phe Ser 
145                 150                 155                 160 


Asp Gly Asn Leu Xaa Tyr Ile Val Glu Pro Gln Glu Val Ala Gly Pro 
                165                 170                 175     


Trp Gly Ala Pro Gln Gly Pro Leu Pro His Leu Ile Tyr Arg Xaa Pro 
            180                 185                 190         


Leu Leu Pro Asp Pro Leu Gly Cys Arg Glu Pro Gly Cys Leu Phe Ala 
        195                 200                 205             


Val Pro Ala Gln Ser Ala Pro Pro Asn Arg Pro Arg Leu Arg Arg Lys 
    210                 215                 220                 


Arg Gln Val Arg Arg Gly His Pro Xaa Val His Ser Glu Xaa Lys Tyr 
225                 230                 235                 240 


Val Glu Leu Ile Val Ile Asn Asp His Gln Leu Phe Glu Gln Met Arg 
                245                 250                 255     


Gln Ser Val Val Leu Xaa Ser Asn Phe Ala Lys Ser Val Val Asn Leu 
            260                 265                 270         


Ala Asp Val Ile Tyr Lys Glu Gln Leu Asn Xaa Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Xaa Trp Ala Asp Gly Asp Lys Ile Gln Val Gln Asp Asp 
    290                 295                 300                 


Leu Leu Glu Xaa Leu Ala Arg Leu Met Val Tyr Arg Arg Glu Gly Leu 
305                 310                 315                 320 


Pro Glu Pro Ser Asp Ala Xaa His Leu Phe Ser Gly Arg Xaa Phe Gln 
                325                 330                 335     


Ser Xaa Ser Ser Gly Ala Ala Tyr Val Gly Gly Ile Cys Ser Leu Ser 
            340                 345                 350         


His Gly Gly Gly Val Asn Glu Tyr Gly Asn Met Gly Ala Met Ala Val 
        355                 360                 365             


Xaa Leu Ala Gln Xaa Leu Gly Gln Asn Leu Gly Met Met Trp Asn Lys 
    370                 375                 380                 


His Arg Ser Ser Ala Gly Asp Cys Lys Cys Pro Asp Ile Trp Leu Gly 
385                 390                 395                 400 


Cys Ile Met Glu Asp Xaa Gly Phe Tyr Leu Pro Arg Lys Phe Ser Arg 
                405                 410                 415     


Cys Ser Ile Asp Glu Tyr Asn Gln Phe Leu Gln Glu Gly Gly Gly Ser 
            420                 425                 430         


Cys Leu Phe Asn Lys Pro Leu Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445             


Asn Gly Phe Val Glu Ala Gly Glu Glu Cys Asp Cys Gly Ser Val Gln 
    450                 455                 460                 


Glu Cys Ser Arg Ala Gly Gly Asn Cys Cys Lys Lys Cys Xaa Leu Xaa 
465                 470                 475                 480 


His Asp Ala Met Cys Ser Asp Gly Leu Cys Cys Arg Arg Cys Lys Tyr 
                485                 490                 495     


Glu Pro Arg Gly Val Ser Cys Arg Glu Ala Val Asn Glu Cys Asp Ile 
            500                 505                 510         


Ala Glu Xaa Cys Xaa Gly Asp Ser Ser Gln Cys Pro Pro Asn Leu His 
        515                 520                 525             


Lys Leu Asp Gly Tyr Tyr Cys Asp His Glu Gln Gly Arg Cys Tyr Gly 
    530                 535                 540                 


Gly Arg Cys Lys Xaa Arg Asp Arg Gln Cys Gln Val Leu Trp Gly His 
545                 550                 555                 560 


Ala Ala Ala Asp Arg Phe Cys Tyr Glu Lys Leu Asn Val Glu Gly Xaa 
                565                 570                 575     


Glu Arg Gly Ser Cys Gly Arg Lys Gly Ser Gly Trp Val Gln Cys Ser 
            580                 585                 590         


Lys Gln Asp Val Leu Cys Gly Phe Leu Leu Cys Val Asn Ile Ser Gly 
        595                 600                 605             


Ala Pro Arg Leu Gly Asp Leu Val Gly Asp Ile Ser Ser Val Xaa Phe 
    610                 615                 620                 


Tyr His Gln Gly Lys Glu Leu Asp Cys Arg Gly Gly His Val Gln Leu 
625                 630                 635                 640 


Ala Asp Gly Ser Asp Leu Ser Tyr Val Glu Asp Gly Xaa Ala Cys Gly 
                645                 650                 655     


Pro Asn Met Leu Cys Leu Asp His Arg Cys Leu Pro Ala Ser Ala Phe 
            660                 665                 670         


Asn Phe Ser Xaa Cys Pro Gly Ser Gly Glu Arg Arg Ile Cys Ser His 
        675                 680                 685             


His Gly Val Cys Ser Asn Glu Gly Lys Cys Ile Cys Gln Pro Asp Trp 
    690                 695                 700                 


Xaa Gly Lys Asp Cys Ser Ile His Asn Pro Leu Pro Xaa Ser Pro Pro 
705                 710                 715                 720 


Xaa Gly Glu Xaa Glu Arg Tyr Lys Gly Pro Ser Gly Xaa Asn Ile Ile 
                725                 730                 735     


Ile Gly Ser Ile Ala Gly Ala Val Leu Val Ala Ala Ile Val Leu Gly 
            740                 745                 750         


Gly Xaa Gly Trp Gly Phe Lys Asn Ile Arg Arg Gly Arg Ser Gly Gly 
        755                 760                 765             


Ala 
    


<210> 1471
<211> 241
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<400> 1471
Met Arg Leu Leu Arg Arg Trp Ala Phe Ala Ala Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Pro Xaa Pro Gly Leu Gly Xaa Gln Gly Pro Ala Gly Ala Leu Arg 
            20                  25                  30          


Trp Gly Gly Leu Pro Gln Leu Gly Gly Pro Gly Ala Pro Glu Val Xaa 
        35                  40                  45              


Glu Pro Ser Arg Leu Val Arg Glu Ser Ser Gly Gly Glu Val Arg Lys 
    50                  55                  60                  


Gln Gln Leu Asp Xaa Arg Val Arg Gln Glu Pro Pro Gly Gly Pro Pro 
65                  70                  75                  80  


Val His Leu Ala Gln Val Ser Phe Val Ile Pro Ala Phe Asn Ser Asn 
                85                  90                  95      


Phe Xaa Leu Asp Leu Glu Leu Asn His His Leu Leu Ser Ser Gln Tyr 
            100                 105                 110         


Val Glu Arg His Phe Ser Arg Glu Gly Xaa Xaa Gln His Ser Xaa Gly 
        115                 120                 125             


Ala Gly Asp His Cys Tyr Tyr Gln Gly Lys Leu Arg Gly Asn Pro His 
    130                 135                 140                 


Ser Phe Ala Ala Leu Ser Xaa Cys Gln Gly Leu His Gly Val Phe Ser 
145                 150                 155                 160 


Asp Gly Asn Leu Xaa Tyr Ile Val Glu Pro Gln Glu Val Ala Gly Pro 
                165                 170                 175     


Trp Gly Ala Pro Gln Gly Pro Leu Pro His Leu Ile Tyr Arg Xaa Pro 
            180                 185                 190         


Leu Leu Pro Asp Pro Leu Gly Cys Arg Glu Pro Gly Cys Leu Phe Ala 
        195                 200                 205             


Val Pro Ala Gln Ser Ala Pro Pro Asn Arg Pro Arg Leu Arg Arg Lys 
    210                 215                 220                 


Arg Ser Ala Gly Ala Xaa Leu Gln Cys Xaa Val Lys Pro Ser Met Trp 
225                 230                 235                 240 


Ser 
    


<210> 1472
<211> 520
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<400> 1472
Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Xaa Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Xaa Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Leu Asn Phe 
                85                  90                  95      


Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys Ala Leu Leu Asp Gly Met 
            100                 105                 110         


Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser Leu Pro Pro Met Ala Ala 
        115                 120                 125             


Phe Cys Gly Asn Met Phe Val Glu Pro Gly Glu Gln Cys Asp Cys Gly 
    130                 135                 140                 


Phe Leu Asp Asp Cys Val Asp Pro Cys Cys Asp Ser Leu Xaa Cys Gln 
145                 150                 155                 160 


Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp Gly Pro Cys Cys Gln Asn 
                165                 170                 175     


Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys Arg Pro Xaa Arg Gly Asp 
            180                 185                 190         


Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp Ser Ser Gln Cys Pro Pro 
        195                 200                 205             


Asp Val Ser Leu Gly Asp Gly Glu Pro Cys Ala Gly Gly Gln Ala Val 
    210                 215                 220                 


Cys Met His Gly Arg Cys Ala Ser Tyr Ala Gln Gln Cys Gln Ser Leu 
225                 230                 235                 240 


Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro Leu Cys Leu Gln Xaa Ala 
                245                 250                 255     


Asn Xaa Arg Gly Asn Ala Phe Gly Ser Cys Gly Arg Asn Pro Ser Gly 
            260                 265                 270         


Ser Tyr Val Ser Cys Xaa Pro Arg Asp Ala Ile Cys Gly Gln Leu Gln 
        275                 280                 285             


Cys Gln Xaa Gly Arg Xaa Gln Pro Leu Leu Gly Ser Ile Arg Asp Leu 
    290                 295                 300                 


Leu Trp Glu Xaa Ile Asp Val Asn Gly Xaa Glu Leu Asn Cys Ser Trp 
305                 310                 315                 320 


Val His Leu Asp Leu Gly Ser Asp Val Ala Gln Pro Leu Leu Xaa Leu 
                325                 330                 335     


Pro Gly Xaa Ala Cys Gly Pro Gly Leu Val Cys Ile Asp His Arg Cys 
            340                 345                 350         


Gln Arg Val Asp Leu Leu Gly Ala Gln Glu Cys Arg Ser Lys Cys His 
        355                 360                 365             


Gly His Gly Val Cys Asp Ser Asn Arg His Cys Tyr Cys Glu Glu Gly 
    370                 375                 380                 


Trp Ala Pro Pro Asp Cys Xaa Xaa Gln Leu Lys Ala Xaa Ser Ser Leu 
385                 390                 395                 400 


Xaa Xaa Gly Leu Leu Leu Ser Leu Leu Val Leu Leu Val Leu Val Met 
                405                 410                 415     


Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg Leu His Gln Arg Leu Cys 
            420                 425                 430         


Gln Leu Lys Gly Pro Xaa Cys Gln Tyr Arg Ala Ala Gln Ser Gly Pro 
        435                 440                 445             


Ser Glu Arg Pro Gly Pro Pro Gln Arg Ala Leu Leu Ala Arg Gly Xaa 
    450                 455                 460                 


Lys Ser Gln Gly Pro Ala Lys Pro Pro Pro Pro Arg Lys Pro Leu Pro 
465                 470                 475                 480 


Ala Asp Pro Gln Gly Arg Cys Pro Ser Gly Asp Leu Pro Gly Pro Gly 
                485                 490                 495     


Ala Gly Ile Pro Pro Leu Val Val Pro Ser Arg Pro Ala Pro Pro Pro 
            500                 505                 510         


Pro Xaa Val Ser Ser Leu Tyr Leu 
        515                 520 


<210> 1473
<211> 772
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<400> 1473
Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Xaa Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Xaa Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Arg Pro Xaa 
                85                  90                  95      


Leu Val Trp Tyr Gln Pro Asp Gly Xaa Arg Val Val Ser Glu Gly His 
            100                 105                 110         


Xaa Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
        115                 120                 125             


Ser Trp Val Ser Ile Cys Xaa Cys Ser Gly Leu Arg Gly Leu Val Val 
    130                 135                 140                 


Leu Xaa Pro Glu Arg Ser Tyr Xaa Leu Glu Gln Gly Pro Gly Asp Leu 
145                 150                 155                 160 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
                165                 170                 175     


His Xaa Cys Ala Leu Ser Trp Arg Glu Ser Val His Xaa Gln Lys Pro 
            180                 185                 190         


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
        195                 200                 205             


Val Xaa Glu Xaa Lys Xaa Val Glu Leu Val Ile Val Ala Asp His Ser 
    210                 215                 220                 


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Xaa Leu 
225                 230                 235                 240 


Glu Val Ala Leu Leu Leu Asp Xaa Phe Phe Arg Pro Leu Asn Val Arg 
                245                 250                 255     


Val Ala Leu Val Gly Leu Glu Ala Trp Xaa Gln Arg Asp Leu Val Glu 
            260                 265                 270         


Ile Ser Pro Asn Pro Ala Val Xaa Leu Glu Asn Phe Leu His Trp Arg 
        275                 280                 285             


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Xaa Gly Xaa Ser Phe Ser Gly Pro Xaa Val Gly Met Ala Ile Gln Asn 
305                 310                 315                 320 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
                325                 330                 335     


Xaa Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
            340                 345                 350         


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
        355                 360                 365             


Gly Pro Ala Pro Ala Lys Xaa Cys Ile Met Glu Ala Ser Xaa Asp Phe 
    370                 375                 380                 


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
                405                 410                 415     


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
            420                 425                 430         


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
        435                 440                 445             


Asp Ser Leu Xaa Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
    450                 455                 460                 


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
465                 470                 475                 480 


Arg Pro Xaa Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
                485                 490                 495     


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
            500                 505                 510         


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
        515                 520                 525             


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
    530                 535                 540                 


Leu Cys Leu Gln Xaa Ala Asn Xaa Arg Gly Asn Ala Phe Gly Ser Cys 
545                 550                 555                 560 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Xaa Pro Arg Asp Ala 
                565                 570                 575     


Ile Cys Gly Gln Leu Gln Cys Gln Xaa Gly Arg Xaa Gln Pro Leu Leu 
            580                 585                 590         


Gly Ser Ile Arg Asp Leu Leu Trp Glu Xaa Ile Asp Val Asn Gly Xaa 
        595                 600                 605             


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
    610                 615                 620                 


Gln Pro Leu Leu Xaa Leu Pro Gly Xaa Ala Cys Gly Pro Gly Leu Val 
625                 630                 635                 640 


Cys Ile Asp His Arg Cys Gln Arg Val Asp Leu Leu Gly Ala Gln Glu 
                645                 650                 655     


Cys Arg Ser Lys Cys His Gly His Gly Val Cys Asp Ser Asn Arg His 
            660                 665                 670         


Cys Tyr Cys Glu Glu Gly Trp Ala Pro Pro Asp Cys Xaa Xaa Gln Leu 
        675                 680                 685             


Lys Ala Xaa Ser Ser Leu Xaa Xaa Gly Leu Leu Leu Ser Leu Leu Val 
    690                 695                 700                 


Leu Leu Val Leu Val Met Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg 
705                 710                 715                 720 


Leu His Gln Arg Leu Cys Gln Leu Lys Gly Pro Xaa Cys Gln Tyr Ser 
                725                 730                 735     


Leu Arg Gly Gln Pro Ser Pro His Pro Gln Gly Ser His Cys Leu Pro 
            740                 745                 750         


Xaa Pro Arg Ala Gly Ala His Arg Val Xaa Cys Pro Ala Gln Gly Leu 
        755                 760                 765             


Glu Ser Arg Pro 
    770         


<210> 1474
<211> 796
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<400> 1474
Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Xaa Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Xaa Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Arg Pro Xaa 
                85                  90                  95      


Leu Val Trp Tyr Gln Pro Asp Gly Xaa Arg Val Val Ser Glu Gly His 
            100                 105                 110         


Xaa Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
        115                 120                 125             


Ser Trp Val Ser Ile Cys Xaa Cys Ser Gly Leu Arg Gly Leu Val Val 
    130                 135                 140                 


Leu Xaa Pro Glu Arg Ser Tyr Xaa Leu Glu Gln Gly Pro Gly Asp Leu 
145                 150                 155                 160 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
                165                 170                 175     


His Xaa Cys Ala Leu Ser Trp Arg Glu Ser Val His Xaa Gln Lys Pro 
            180                 185                 190         


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
        195                 200                 205             


Val Xaa Glu Xaa Lys Xaa Val Glu Leu Val Ile Val Ala Asp His Ser 
    210                 215                 220                 


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Xaa Leu 
225                 230                 235                 240 


Glu Val Ala Leu Leu Leu Asp Xaa Phe Phe Arg Pro Leu Asn Val Arg 
                245                 250                 255     


Val Ala Leu Val Gly Leu Glu Ala Trp Xaa Gln Arg Asp Leu Val Glu 
            260                 265                 270         


Ile Ser Pro Asn Pro Ala Val Xaa Leu Glu Asn Phe Leu His Trp Arg 
        275                 280                 285             


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Xaa Gly Xaa Ser Phe Ser Gly Pro Xaa Val Gly Met Ala Ile Gln Asn 
305                 310                 315                 320 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
                325                 330                 335     


Xaa Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
            340                 345                 350         


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
        355                 360                 365             


Gly Pro Ala Pro Ala Lys Xaa Cys Ile Met Glu Ala Ser Xaa Asp Phe 
    370                 375                 380                 


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
                405                 410                 415     


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
            420                 425                 430         


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
        435                 440                 445             


Asp Ser Leu Xaa Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
    450                 455                 460                 


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
465                 470                 475                 480 


Arg Pro Xaa Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
                485                 490                 495     


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
            500                 505                 510         


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
        515                 520                 525             


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
    530                 535                 540                 


Leu Cys Leu Gln Xaa Ala Asn Xaa Arg Gly Asn Ala Phe Gly Ser Cys 
545                 550                 555                 560 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Xaa Pro Arg Asp Ala 
                565                 570                 575     


Ile Cys Gly Gln Leu Gln Cys Gln Xaa Gly Arg Xaa Gln Pro Leu Leu 
            580                 585                 590         


Gly Ser Ile Arg Asp Leu Leu Trp Glu Xaa Ile Asp Val Asn Gly Xaa 
        595                 600                 605             


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
    610                 615                 620                 


Gln Pro Leu Leu Xaa Leu Pro Gly Xaa Ala Cys Gly Pro Gly Leu Val 
625                 630                 635                 640 


Cys Ile Asp His Arg Cys Gln Arg Val Asp Leu Leu Gly Ala Gln Glu 
                645                 650                 655     


Cys Arg Ser Lys Cys His Gly His Gly Val Cys Asp Ser Asn Arg His 
            660                 665                 670         


Cys Tyr Cys Glu Glu Gly Trp Ala Pro Pro Asp Cys Xaa Xaa Gln Leu 
        675                 680                 685             


Lys Ala Xaa Ser Ser Leu Xaa Xaa Gly Leu Leu Leu Ser Leu Leu Val 
    690                 695                 700                 


Leu Leu Val Leu Val Met Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg 
705                 710                 715                 720 


Leu His Gln Arg Leu Cys Gln Leu Lys Gly Pro Xaa Cys Gln Tyr Arg 
                725                 730                 735     


Leu Val Leu Ser Ala Ser Arg Pro Pro Leu Pro Gly Arg Cys Arg Leu 
            740                 745                 750         


Xaa Leu Cys Pro Arg Asp Ser Ser Leu Arg Gly Gln Pro Ser Pro His 
        755                 760                 765             


Pro Gln Gly Ser His Cys Leu Pro Xaa Pro Arg Ala Gly Ala His Arg 
    770                 775                 780                 


Val Xaa Cys Pro Ala Gln Gly Leu Glu Ser Arg Pro 
785                 790                 795     


<210> 1475
<211> 797
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<400> 1475
Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Xaa Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Xaa Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Arg Pro Xaa 
                85                  90                  95      


Leu Val Trp Tyr Gln Pro Asp Gly Xaa Arg Val Val Ser Glu Gly His 
            100                 105                 110         


Xaa Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
        115                 120                 125             


Ser Trp Val Ser Ile Cys Xaa Cys Ser Gly Leu Arg Gly Leu Val Val 
    130                 135                 140                 


Leu Xaa Pro Glu Arg Ser Tyr Xaa Leu Glu Gln Gly Pro Gly Asp Leu 
145                 150                 155                 160 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
                165                 170                 175     


His Xaa Cys Ala Leu Ser Trp Arg Glu Ser Val His Xaa Gln Lys Pro 
            180                 185                 190         


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
        195                 200                 205             


Val Xaa Glu Xaa Lys Xaa Val Glu Leu Val Ile Val Ala Asp His Ser 
    210                 215                 220                 


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Xaa Leu 
225                 230                 235                 240 


Glu Val Ala Leu Leu Leu Asp Xaa Phe Phe Arg Pro Leu Asn Val Arg 
                245                 250                 255     


Val Ala Leu Val Gly Leu Glu Ala Trp Xaa Gln Arg Asp Leu Val Glu 
            260                 265                 270         


Ile Ser Pro Asn Pro Ala Val Xaa Leu Glu Asn Phe Leu His Trp Arg 
        275                 280                 285             


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Xaa Gly Xaa Ser Phe Ser Gly Pro Xaa Val Gly Met Ala Ile Gln Asn 
305                 310                 315                 320 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
                325                 330                 335     


Xaa Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
            340                 345                 350         


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
        355                 360                 365             


Gly Pro Ala Pro Ala Lys Xaa Cys Ile Met Glu Ala Ser Xaa Asp Phe 
    370                 375                 380                 


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
                405                 410                 415     


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
            420                 425                 430         


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
        435                 440                 445             


Asp Ser Leu Xaa Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
    450                 455                 460                 


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
465                 470                 475                 480 


Arg Pro Xaa Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
                485                 490                 495     


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
            500                 505                 510         


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
        515                 520                 525             


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
    530                 535                 540                 


Leu Cys Leu Gln Xaa Ala Asn Xaa Arg Gly Asn Ala Phe Gly Ser Cys 
545                 550                 555                 560 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Xaa Pro Arg Asp Ala 
                565                 570                 575     


Ile Cys Gly Gln Leu Gln Cys Gln Xaa Gly Arg Xaa Gln Pro Leu Leu 
            580                 585                 590         


Gly Ser Ile Arg Asp Leu Leu Trp Glu Xaa Ile Asp Val Asn Gly Xaa 
        595                 600                 605             


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
    610                 615                 620                 


Gln Pro Leu Leu Xaa Leu Pro Gly Xaa Ala Cys Gly Pro Gly Leu Val 
625                 630                 635                 640 


Cys Ile Asp His Arg Cys Gln Arg Val Asp Leu Leu Gly Ala Gln Glu 
                645                 650                 655     


Cys Arg Ser Lys Cys His Gly His Gly Val Cys Asp Ser Asn Arg His 
            660                 665                 670         


Cys Tyr Cys Glu Glu Gly Trp Ala Pro Pro Asp Cys Xaa Xaa Gln Leu 
        675                 680                 685             


Lys Ala Xaa Ser Ser Leu Xaa Xaa Gly Leu Leu Leu Ser Leu Leu Val 
    690                 695                 700                 


Leu Leu Val Leu Val Met Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg 
705                 710                 715                 720 


Leu His Gln Arg Leu Cys Gln Leu Lys Gly Pro Xaa Cys Gln Tyr Arg 
                725                 730                 735     


Ala Ala Gln Ser Gly Pro Ser Glu Arg Pro Gly Pro Pro Gln Arg Ala 
            740                 745                 750         


Leu Leu Ala Arg Gly Xaa Lys Ala Glu Leu Ala Asp Arg Pro Asn Pro 
        755                 760                 765             


Pro Xaa Arg Pro Leu Pro Ala Asp Pro Val Val Arg Ser Pro Lys Val 
    770                 775                 780                 


Xaa Val Gly Gly Glu Lys Gly Xaa Ala Ser Pro Pro Xaa 
785                 790                 795         


<210> 1476
<211> 814
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<400> 1476
Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Xaa Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Xaa Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Arg Pro Xaa 
                85                  90                  95      


Leu Val Trp Tyr Gln Pro Asp Gly Xaa Arg Val Val Ser Glu Gly His 
            100                 105                 110         


Xaa Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
        115                 120                 125             


Ser Trp Val Ser Ile Cys Xaa Cys Ser Gly Leu Arg Gly Leu Val Val 
    130                 135                 140                 


Leu Xaa Pro Glu Arg Ser Tyr Xaa Leu Glu Gln Gly Pro Gly Asp Leu 
145                 150                 155                 160 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
                165                 170                 175     


His Xaa Cys Ala Leu Ser Trp Arg Glu Ser Val His Xaa Gln Lys Pro 
            180                 185                 190         


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
        195                 200                 205             


Val Xaa Glu Xaa Lys Xaa Val Glu Leu Val Ile Val Ala Asp His Ser 
    210                 215                 220                 


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Xaa Leu 
225                 230                 235                 240 


Glu Val Ala Leu Leu Leu Asp Xaa Phe Phe Arg Pro Leu Asn Val Arg 
                245                 250                 255     


Val Ala Leu Val Gly Leu Glu Ala Trp Xaa Gln Arg Asp Leu Val Glu 
            260                 265                 270         


Ile Ser Pro Asn Pro Ala Val Xaa Leu Glu Asn Phe Leu His Trp Arg 
        275                 280                 285             


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Xaa Gly Xaa Ser Phe Ser Gly Pro Xaa Val Gly Met Ala Ile Gln Asn 
305                 310                 315                 320 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
                325                 330                 335     


Xaa Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
            340                 345                 350         


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
        355                 360                 365             


Gly Pro Ala Pro Ala Lys Xaa Cys Ile Met Glu Ala Ser Xaa Asp Phe 
    370                 375                 380                 


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
                405                 410                 415     


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
            420                 425                 430         


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
        435                 440                 445             


Asp Ser Leu Xaa Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
    450                 455                 460                 


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
465                 470                 475                 480 


Arg Pro Xaa Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
                485                 490                 495     


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
            500                 505                 510         


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
        515                 520                 525             


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
    530                 535                 540                 


Leu Cys Leu Gln Xaa Ala Asn Xaa Arg Gly Asn Ala Phe Gly Ser Cys 
545                 550                 555                 560 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Xaa Pro Arg Asp Ala 
                565                 570                 575     


Ile Cys Gly Gln Leu Gln Cys Gln Xaa Gly Arg Xaa Gln Pro Leu Leu 
            580                 585                 590         


Gly Ser Ile Arg Asp Leu Leu Trp Glu Xaa Ile Asp Val Asn Gly Xaa 
        595                 600                 605             


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
    610                 615                 620                 


Gln Pro Leu Leu Xaa Leu Pro Gly Xaa Ala Cys Gly Pro Gly Leu Val 
625                 630                 635                 640 


Cys Ile Asp His Arg Cys Gln Arg Val Asp Leu Leu Gly Ala Gln Glu 
                645                 650                 655     


Cys Arg Ser Lys Cys His Gly His Gly Val Cys Asp Ser Asn Arg His 
            660                 665                 670         


Cys Tyr Cys Glu Glu Gly Trp Ala Pro Pro Asp Cys Xaa Xaa Gln Leu 
        675                 680                 685             


Lys Ala Xaa Ser Ser Leu Xaa Xaa Gly Leu Leu Leu Ser Leu Leu Val 
    690                 695                 700                 


Leu Leu Val Leu Val Met Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg 
705                 710                 715                 720 


Leu His Gln Arg Leu Cys Gln Leu Lys Gly Pro Xaa Cys Gln Tyr Arg 
                725                 730                 735     


Ala Ala Gln Ser Gly Pro Ser Glu Arg Pro Gly Pro Pro Gln Arg Ala 
            740                 745                 750         


Leu Leu Ala Arg Gly Xaa Lys Ser Gln Gly Pro Ala Lys Pro Pro Pro 
        755                 760                 765             


Pro Arg Lys Pro Leu Pro Ala Asp Pro Gln Gly Arg Cys Pro Ser Gly 
    770                 775                 780                 


Asp Leu Pro Gly Pro Gly Ala Gly Ile Pro Pro Leu Val Val Pro Ser 
785                 790                 795                 800 


Arg Pro Ala Pro Pro Pro Pro Xaa Val Ser Ser Leu Tyr Leu 
                805                 810                 


<210> 1477
<211> 822
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<400> 1477
Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Xaa Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Xaa Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Arg Pro Xaa 
                85                  90                  95      


Leu Val Trp Tyr Gln Pro Asp Gly Xaa Arg Val Val Ser Glu Gly His 
            100                 105                 110         


Xaa Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
        115                 120                 125             


Ser Trp Val Ser Ile Cys Xaa Cys Ser Gly Leu Arg Gly Leu Val Val 
    130                 135                 140                 


Leu Xaa Pro Glu Arg Ser Tyr Xaa Leu Glu Gln Gly Pro Gly Asp Leu 
145                 150                 155                 160 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
                165                 170                 175     


His Xaa Cys Ala Leu Ser Trp Arg Glu Ser Val His Xaa Gln Lys Pro 
            180                 185                 190         


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
        195                 200                 205             


Val Xaa Glu Xaa Lys Xaa Val Glu Leu Val Ile Val Ala Asp His Ser 
    210                 215                 220                 


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Xaa Leu 
225                 230                 235                 240 


Glu Val Ala Leu Leu Leu Asp Xaa Phe Phe Arg Pro Leu Asn Val Arg 
                245                 250                 255     


Val Ala Leu Val Gly Leu Glu Ala Trp Xaa Gln Arg Asp Leu Val Glu 
            260                 265                 270         


Ile Ser Pro Asn Pro Ala Val Xaa Leu Glu Asn Phe Leu His Trp Arg 
        275                 280                 285             


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Xaa Gly Xaa Ser Phe Ser Gly Pro Xaa Val Gly Met Ala Ile Gln Asn 
305                 310                 315                 320 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
                325                 330                 335     


Xaa Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
            340                 345                 350         


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
        355                 360                 365             


Gly Pro Ala Pro Ala Lys Xaa Cys Ile Met Glu Ala Ser Xaa Asp Phe 
    370                 375                 380                 


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
                405                 410                 415     


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
            420                 425                 430         


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
        435                 440                 445             


Asp Ser Leu Xaa Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
    450                 455                 460                 


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
465                 470                 475                 480 


Arg Pro Xaa Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
                485                 490                 495     


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
            500                 505                 510         


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
        515                 520                 525             


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
    530                 535                 540                 


Leu Cys Leu Gln Xaa Ala Asn Xaa Arg Gly Asn Ala Phe Gly Ser Cys 
545                 550                 555                 560 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Xaa Pro Arg Asp Ala 
                565                 570                 575     


Ile Cys Gly Gln Leu Gln Cys Gln Xaa Gly Arg Xaa Gln Pro Leu Leu 
            580                 585                 590         


Gly Ser Ile Arg Asp Leu Leu Trp Glu Xaa Ile Asp Val Asn Gly Xaa 
        595                 600                 605             


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
    610                 615                 620                 


Gln Pro Leu Leu Xaa Leu Pro Gly Xaa Ala Cys Gly Pro Gly Leu Val 
625                 630                 635                 640 


Cys Ile Asp His Arg Cys Gln Arg Val Asp Leu Leu Gly Ala Gln Glu 
                645                 650                 655     


Cys Arg Ser Lys Cys His Gly His Gly Val Cys Asp Ser Asn Arg His 
            660                 665                 670         


Cys Tyr Cys Glu Glu Gly Trp Ala Pro Pro Asp Cys Xaa Xaa Gln Leu 
        675                 680                 685             


Lys Ala Xaa Ser Ser Leu Xaa Xaa Gly Leu Leu Leu Ser Leu Leu Val 
    690                 695                 700                 


Leu Leu Val Leu Val Met Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg 
705                 710                 715                 720 


Leu His Gln Arg Leu Cys Gln Leu Lys Gly Pro Xaa Cys Gln Tyr Arg 
                725                 730                 735     


Ala Ala Gln Ser Gly Pro Ser Glu Arg Pro Gly Pro Pro Gln Arg Ala 
            740                 745                 750         


Leu Leu Ala Arg Gly Xaa Lys Gln Ala Ser Ala Leu Ser Phe Pro Ala 
        755                 760                 765             


Pro Pro Ser Arg Pro Leu Pro Pro Asp Pro Val Ser Lys Arg Leu Gln 
    770                 775                 780                 


Ala Glu Leu Ala Asp Arg Pro Asn Pro Pro Xaa Arg Pro Leu Pro Ala 
785                 790                 795                 800 


Asp Pro Val Val Arg Ser Pro Lys Val Xaa Val Gly Gly Glu Lys Gly 
                805                 810                 815     


Xaa Ala Ser Pro Pro Xaa 
            820         


<210> 1478
<211> 838
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<400> 1478
Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Xaa Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Xaa Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Arg Pro Xaa 
                85                  90                  95      


Leu Val Trp Tyr Gln Pro Asp Gly Xaa Arg Val Val Ser Glu Gly His 
            100                 105                 110         


Xaa Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
        115                 120                 125             


Ser Trp Val Ser Ile Cys Xaa Cys Ser Gly Leu Arg Gly Leu Val Val 
    130                 135                 140                 


Leu Xaa Pro Glu Arg Ser Tyr Xaa Leu Glu Gln Gly Pro Gly Asp Leu 
145                 150                 155                 160 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
                165                 170                 175     


His Xaa Cys Ala Leu Ser Trp Arg Glu Ser Val His Xaa Gln Lys Pro 
            180                 185                 190         


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
        195                 200                 205             


Val Xaa Glu Xaa Lys Xaa Val Glu Leu Val Ile Val Ala Asp His Ser 
    210                 215                 220                 


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Xaa Leu 
225                 230                 235                 240 


Glu Val Ala Leu Leu Leu Asp Xaa Phe Phe Arg Pro Leu Asn Val Arg 
                245                 250                 255     


Val Ala Leu Val Gly Leu Glu Ala Trp Xaa Gln Arg Asp Leu Val Glu 
            260                 265                 270         


Ile Ser Pro Asn Pro Ala Val Xaa Leu Glu Asn Phe Leu His Trp Arg 
        275                 280                 285             


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Xaa Gly Xaa Ser Phe Ser Gly Pro Xaa Val Gly Met Ala Ile Gln Asn 
305                 310                 315                 320 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
                325                 330                 335     


Xaa Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
            340                 345                 350         


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
        355                 360                 365             


Gly Pro Ala Pro Ala Lys Xaa Cys Ile Met Glu Ala Ser Xaa Asp Phe 
    370                 375                 380                 


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
                405                 410                 415     


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
            420                 425                 430         


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
        435                 440                 445             


Asp Ser Leu Xaa Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
    450                 455                 460                 


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
465                 470                 475                 480 


Arg Pro Xaa Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
                485                 490                 495     


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
            500                 505                 510         


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
        515                 520                 525             


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
    530                 535                 540                 


Leu Cys Leu Gln Xaa Ala Asn Xaa Arg Gly Asn Ala Phe Gly Ser Cys 
545                 550                 555                 560 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Xaa Pro Arg Asp Ala 
                565                 570                 575     


Ile Cys Gly Gln Leu Gln Cys Gln Xaa Gly Arg Xaa Gln Pro Leu Leu 
            580                 585                 590         


Gly Ser Ile Arg Asp Leu Leu Trp Glu Xaa Ile Asp Val Asn Gly Xaa 
        595                 600                 605             


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
    610                 615                 620                 


Gln Pro Leu Leu Xaa Leu Pro Gly Xaa Ala Cys Gly Pro Gly Leu Val 
625                 630                 635                 640 


Cys Ile Asp His Arg Cys Gln Arg Val Asp Leu Leu Gly Ala Gln Glu 
                645                 650                 655     


Cys Arg Ser Lys Cys His Gly His Gly Val Cys Asp Ser Asn Arg His 
            660                 665                 670         


Cys Tyr Cys Glu Glu Gly Trp Ala Pro Pro Asp Cys Xaa Xaa Gln Leu 
        675                 680                 685             


Lys Ala Xaa Ser Ser Leu Xaa Xaa Gly Leu Leu Leu Ser Leu Leu Val 
    690                 695                 700                 


Leu Leu Val Leu Val Met Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg 
705                 710                 715                 720 


Leu His Gln Arg Leu Cys Gln Leu Lys Gly Pro Xaa Cys Gln Tyr Arg 
                725                 730                 735     


Ala Ala Gln Ser Gly Pro Ser Glu Arg Pro Gly Pro Pro Gln Arg Ala 
            740                 745                 750         


Leu Leu Ala Arg Gly Xaa Lys Ala Glu Leu Ala Asp Arg Pro Asn Pro 
        755                 760                 765             


Pro Xaa Arg Pro Leu Pro Ala Asp Pro Val Val Arg Ser Pro Lys Ser 
    770                 775                 780                 


Gln Gly Pro Ala Lys Pro Pro Pro Pro Arg Lys Pro Leu Pro Ala Asp 
785                 790                 795                 800 


Pro Gln Gly Arg Cys Pro Ser Gly Asp Leu Pro Gly Pro Gly Ala Gly 
                805                 810                 815     


Ile Pro Pro Leu Val Val Pro Ser Arg Pro Ala Pro Pro Pro Pro Xaa 
            820                 825                 830         


Val Ser Ser Leu Tyr Leu 
        835             


<210> 1479
<211> 839
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<400> 1479
Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Xaa Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Xaa Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Arg Pro Xaa 
                85                  90                  95      


Leu Val Trp Tyr Gln Pro Asp Gly Xaa Arg Val Val Ser Glu Gly His 
            100                 105                 110         


Xaa Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
        115                 120                 125             


Ser Trp Val Ser Ile Cys Xaa Cys Ser Gly Leu Arg Gly Leu Val Val 
    130                 135                 140                 


Leu Xaa Pro Glu Arg Ser Tyr Xaa Leu Glu Gln Gly Pro Gly Asp Leu 
145                 150                 155                 160 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
                165                 170                 175     


His Xaa Cys Ala Leu Ser Trp Arg Glu Ser Val His Xaa Gln Lys Pro 
            180                 185                 190         


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
        195                 200                 205             


Val Xaa Glu Xaa Lys Xaa Val Glu Leu Val Ile Val Ala Asp His Ser 
    210                 215                 220                 


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Xaa Leu 
225                 230                 235                 240 


Glu Val Ala Leu Leu Leu Asp Xaa Phe Phe Arg Pro Leu Asn Val Arg 
                245                 250                 255     


Val Ala Leu Val Gly Leu Glu Ala Trp Xaa Gln Arg Asp Leu Val Glu 
            260                 265                 270         


Ile Ser Pro Asn Pro Ala Val Xaa Leu Glu Asn Phe Leu His Trp Arg 
        275                 280                 285             


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Xaa Gly Xaa Ser Phe Ser Gly Pro Xaa Val Gly Met Ala Ile Gln Asn 
305                 310                 315                 320 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
                325                 330                 335     


Xaa Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
            340                 345                 350         


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
        355                 360                 365             


Gly Pro Ala Pro Ala Lys Xaa Cys Ile Met Glu Ala Ser Xaa Asp Phe 
    370                 375                 380                 


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
                405                 410                 415     


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
            420                 425                 430         


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
        435                 440                 445             


Asp Ser Leu Xaa Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
    450                 455                 460                 


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
465                 470                 475                 480 


Arg Pro Xaa Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
                485                 490                 495     


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
            500                 505                 510         


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
        515                 520                 525             


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
    530                 535                 540                 


Leu Cys Leu Gln Xaa Ala Asn Xaa Arg Gly Asn Ala Phe Gly Ser Cys 
545                 550                 555                 560 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Xaa Pro Arg Asp Ala 
                565                 570                 575     


Ile Cys Gly Gln Leu Gln Cys Gln Xaa Gly Arg Xaa Gln Pro Leu Leu 
            580                 585                 590         


Gly Ser Ile Arg Asp Leu Leu Trp Glu Xaa Ile Asp Val Asn Gly Xaa 
        595                 600                 605             


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
    610                 615                 620                 


Gln Pro Leu Leu Xaa Leu Pro Gly Xaa Ala Cys Gly Pro Gly Leu Val 
625                 630                 635                 640 


Cys Ile Asp His Arg Cys Gln Arg Val Asp Leu Leu Gly Ala Gln Glu 
                645                 650                 655     


Cys Arg Ser Lys Cys His Gly His Gly Val Cys Asp Ser Asn Arg His 
            660                 665                 670         


Cys Tyr Cys Glu Glu Gly Trp Ala Pro Pro Asp Cys Xaa Xaa Gln Leu 
        675                 680                 685             


Lys Ala Xaa Ser Ser Leu Xaa Xaa Gly Leu Leu Leu Ser Leu Leu Val 
    690                 695                 700                 


Leu Leu Val Leu Val Met Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg 
705                 710                 715                 720 


Leu His Gln Arg Leu Cys Gln Leu Lys Gly Pro Xaa Cys Gln Tyr Arg 
                725                 730                 735     


Ala Ala Gln Ser Gly Pro Ser Glu Arg Pro Gly Pro Pro Gln Arg Ala 
            740                 745                 750         


Leu Leu Ala Arg Gly Xaa Lys Gln Ala Ser Ala Leu Ser Phe Pro Ala 
        755                 760                 765             


Pro Pro Ser Arg Pro Leu Pro Pro Asp Pro Val Ser Lys Arg Leu Gln 
    770                 775                 780                 


Ser Gln Gly Pro Ala Lys Pro Pro Pro Pro Arg Lys Pro Leu Pro Ala 
785                 790                 795                 800 


Asp Pro Gln Gly Arg Cys Pro Ser Gly Asp Leu Pro Gly Pro Gly Ala 
                805                 810                 815     


Gly Ile Pro Pro Leu Val Val Pro Ser Arg Pro Ala Pro Pro Pro Pro 
            820                 825                 830         


Xaa Val Ser Ser Leu Tyr Leu 
        835                 


<210> 1480
<211> 862
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<400> 1480
Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Xaa Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Xaa Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Arg Pro Xaa 
                85                  90                  95      


Leu Val Trp Tyr Gln Pro Asp Gly Xaa Arg Val Val Ser Glu Gly His 
            100                 105                 110         


Xaa Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
        115                 120                 125             


Ser Trp Val Ser Ile Cys Xaa Cys Ser Gly Leu Arg Gly Leu Val Val 
    130                 135                 140                 


Leu Xaa Pro Glu Arg Ser Tyr Xaa Leu Glu Gln Gly Pro Gly Asp Leu 
145                 150                 155                 160 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
                165                 170                 175     


His Xaa Cys Ala Leu Ser Trp Arg Glu Ser Val His Xaa Gln Lys Pro 
            180                 185                 190         


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
        195                 200                 205             


Val Xaa Glu Xaa Lys Xaa Val Glu Leu Val Ile Val Ala Asp His Ser 
    210                 215                 220                 


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Xaa Leu 
225                 230                 235                 240 


Glu Val Ala Leu Leu Leu Asp Xaa Phe Phe Arg Pro Leu Asn Val Arg 
                245                 250                 255     


Val Ala Leu Val Gly Leu Glu Ala Trp Xaa Gln Arg Asp Leu Val Glu 
            260                 265                 270         


Ile Ser Pro Asn Pro Ala Val Xaa Leu Glu Asn Phe Leu His Trp Arg 
        275                 280                 285             


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Xaa Gly Xaa Ser Phe Ser Gly Pro Xaa Val Gly Met Ala Ile Gln Asn 
305                 310                 315                 320 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
                325                 330                 335     


Xaa Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
            340                 345                 350         


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
        355                 360                 365             


Gly Pro Ala Pro Ala Lys Xaa Cys Ile Met Glu Ala Ser Xaa Asp Phe 
    370                 375                 380                 


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
                405                 410                 415     


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
            420                 425                 430         


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
        435                 440                 445             


Asp Ser Leu Xaa Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
    450                 455                 460                 


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
465                 470                 475                 480 


Arg Pro Xaa Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
                485                 490                 495     


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
            500                 505                 510         


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
        515                 520                 525             


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
    530                 535                 540                 


Leu Cys Leu Gln Xaa Ala Asn Xaa Arg Gly Asn Ala Phe Gly Ser Cys 
545                 550                 555                 560 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Xaa Pro Arg Asp Ala 
                565                 570                 575     


Ile Cys Gly Gln Leu Gln Cys Gln Xaa Gly Arg Xaa Gln Pro Leu Leu 
            580                 585                 590         


Gly Ser Ile Arg Asp Leu Leu Trp Glu Xaa Ile Asp Val Asn Gly Xaa 
        595                 600                 605             


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
    610                 615                 620                 


Gln Pro Leu Leu Xaa Leu Pro Gly Xaa Ala Cys Gly Pro Gly Leu Val 
625                 630                 635                 640 


Cys Ile Asp His Arg Cys Gln Arg Val Asp Leu Leu Gly Ala Gln Glu 
                645                 650                 655     


Cys Arg Ser Lys Cys His Gly His Gly Val Cys Asp Ser Asn Arg His 
            660                 665                 670         


Cys Tyr Cys Glu Glu Gly Trp Ala Pro Pro Asp Cys Xaa Xaa Gln Leu 
        675                 680                 685             


Lys Ala Xaa Ser Ser Leu Xaa Xaa Gly Leu Leu Leu Ser Leu Leu Val 
    690                 695                 700                 


Leu Leu Val Leu Val Met Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg 
705                 710                 715                 720 


Leu His Gln Arg Leu Cys Gln Leu Lys Gly Pro Xaa Cys Gln Tyr Arg 
                725                 730                 735     


Ala Ala Gln Ser Gly Pro Ser Glu Arg Pro Gly Pro Pro Gln Arg Ala 
            740                 745                 750         


Leu Leu Ala Arg Gly Xaa Lys Ala Ser Ala Leu Ser Phe Pro Ala Pro 
        755                 760                 765             


Pro Ser Arg Pro Leu Pro Pro Asp Pro Val Ser Lys Arg Leu Gln Ala 
    770                 775                 780                 


Glu Leu Ala Asp Arg Pro Asn Pro Pro Xaa Arg Pro Leu Pro Ala Asp 
785                 790                 795                 800 


Pro Val Val Arg Ser Pro Lys Ser Gln Gly Pro Ala Lys Pro Pro Pro 
                805                 810                 815     


Pro Arg Lys Pro Leu Pro Ala Asp Pro Gln Gly Arg Cys Pro Ser Gly 
            820                 825                 830         


Asp Leu Pro Gly Pro Gly Ala Gly Ile Pro Pro Leu Val Val Pro Ser 
        835                 840                 845             


Arg Pro Ala Pro Pro Pro Pro Xaa Val Ser Ser Leu Tyr Leu 
    850                 855                 860         


<210> 1481
<211> 863
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<400> 1481
Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Xaa Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Xaa Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Arg Pro Xaa 
                85                  90                  95      


Leu Val Trp Tyr Gln Pro Asp Gly Xaa Arg Val Val Ser Glu Gly His 
            100                 105                 110         


Xaa Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
        115                 120                 125             


Ser Trp Val Ser Ile Cys Xaa Cys Ser Gly Leu Arg Gly Leu Val Val 
    130                 135                 140                 


Leu Xaa Pro Glu Arg Ser Tyr Xaa Leu Glu Gln Gly Pro Gly Asp Leu 
145                 150                 155                 160 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
                165                 170                 175     


His Xaa Cys Ala Leu Ser Trp Arg Glu Ser Val His Xaa Gln Lys Pro 
            180                 185                 190         


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
        195                 200                 205             


Val Xaa Glu Xaa Lys Xaa Val Glu Leu Val Ile Val Ala Asp His Ser 
    210                 215                 220                 


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Xaa Leu 
225                 230                 235                 240 


Glu Val Ala Leu Leu Leu Asp Xaa Phe Phe Arg Pro Leu Asn Val Arg 
                245                 250                 255     


Val Ala Leu Val Gly Leu Glu Ala Trp Xaa Gln Arg Asp Leu Val Glu 
            260                 265                 270         


Ile Ser Pro Asn Pro Ala Val Xaa Leu Glu Asn Phe Leu His Trp Arg 
        275                 280                 285             


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Xaa Gly Xaa Ser Phe Ser Gly Pro Xaa Val Gly Met Ala Ile Gln Asn 
305                 310                 315                 320 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
                325                 330                 335     


Xaa Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
            340                 345                 350         


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
        355                 360                 365             


Gly Pro Ala Pro Ala Lys Xaa Cys Ile Met Glu Ala Ser Xaa Asp Phe 
    370                 375                 380                 


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
                405                 410                 415     


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
            420                 425                 430         


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
        435                 440                 445             


Asp Ser Leu Xaa Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
    450                 455                 460                 


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
465                 470                 475                 480 


Arg Pro Xaa Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
                485                 490                 495     


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
            500                 505                 510         


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
        515                 520                 525             


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
    530                 535                 540                 


Leu Cys Leu Gln Xaa Ala Asn Xaa Arg Gly Asn Ala Phe Gly Ser Cys 
545                 550                 555                 560 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Xaa Pro Arg Asp Ala 
                565                 570                 575     


Ile Cys Gly Gln Leu Gln Cys Gln Xaa Gly Arg Xaa Gln Pro Leu Leu 
            580                 585                 590         


Gly Ser Ile Arg Asp Leu Leu Trp Glu Xaa Ile Asp Val Asn Gly Xaa 
        595                 600                 605             


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
    610                 615                 620                 


Gln Pro Leu Leu Xaa Leu Pro Gly Xaa Ala Cys Gly Pro Gly Leu Val 
625                 630                 635                 640 


Cys Ile Asp His Arg Cys Gln Arg Val Asp Leu Leu Gly Ala Gln Glu 
                645                 650                 655     


Cys Arg Ser Lys Cys His Gly His Gly Val Cys Asp Ser Asn Arg His 
            660                 665                 670         


Cys Tyr Cys Glu Glu Gly Trp Ala Pro Pro Asp Cys Xaa Xaa Gln Leu 
        675                 680                 685             


Lys Ala Xaa Ser Ser Leu Xaa Xaa Gly Leu Leu Leu Ser Leu Leu Val 
    690                 695                 700                 


Leu Leu Val Leu Val Met Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg 
705                 710                 715                 720 


Leu His Gln Arg Leu Cys Gln Leu Lys Gly Pro Xaa Cys Gln Tyr Arg 
                725                 730                 735     


Ala Ala Gln Ser Gly Pro Ser Glu Arg Pro Gly Pro Pro Gln Arg Ala 
            740                 745                 750         


Leu Leu Ala Arg Gly Xaa Lys Gln Ala Ser Ala Leu Ser Phe Pro Ala 
        755                 760                 765             


Pro Pro Ser Arg Pro Leu Pro Pro Asp Pro Val Ser Lys Arg Leu Gln 
    770                 775                 780                 


Ala Glu Leu Ala Asp Arg Pro Asn Pro Pro Xaa Arg Pro Leu Pro Ala 
785                 790                 795                 800 


Asp Pro Val Val Arg Ser Pro Lys Ser Gln Gly Pro Ala Lys Pro Pro 
                805                 810                 815     


Pro Pro Arg Lys Pro Leu Pro Ala Asp Pro Gln Gly Arg Cys Pro Ser 
            820                 825                 830         


Gly Asp Leu Pro Gly Pro Gly Ala Gly Ile Pro Pro Leu Val Val Pro 
        835                 840                 845             


Ser Arg Pro Ala Pro Pro Pro Pro Xaa Val Ser Ser Leu Tyr Leu 
    850                 855                 860             


<210> 1482
<211> 824
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<400> 1482
Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Val Leu Ser Trp Gly Val 
            20                  25                  30          


Leu Gly Pro Ala Gly Gly Xaa Glu Glu Gln Gln Ala Glu Ser Glu Lys 
        35                  40                  45              


Ala Pro Arg Glu Pro Leu Glu Pro Gln Val Leu Gln Asp Asp Leu Pro 
    50                  55                  60                  


Ile Ser Leu Lys Lys Val Leu Gln Xaa Ser Leu Pro Glu Pro Leu Arg 
65                  70                  75                  80  


Ile Lys Leu Glu Leu Asp Gly Asp Ser His Ile Leu Glu Leu Leu Gln 
                85                  90                  95      


Asn Arg Glu Leu Val Pro Gly Arg Pro Xaa Leu Val Trp Tyr Gln Pro 
            100                 105                 110         


Asp Gly Xaa Arg Val Val Ser Glu Gly His Xaa Leu Glu Asn Cys Cys 
        115                 120                 125             


Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly Ser Trp Val Ser Ile Cys 
    130                 135                 140                 


Xaa Cys Ser Gly Leu Arg Gly Leu Val Val Leu Xaa Pro Glu Arg Ser 
145                 150                 155                 160 


Tyr Xaa Leu Glu Gln Gly Pro Gly Asp Leu Gln Gly Pro Pro Ile Ile 
                165                 170                 175     


Ser Arg Ile Gln Asp Leu His Leu Pro Gly His Xaa Cys Ala Leu Ser 
            180                 185                 190         


Trp Arg Glu Ser Val His Xaa Gln Lys Pro Pro Glu His Pro Leu Gly 
        195                 200                 205             


Gln Arg His Ile Arg Arg Arg Arg Asp Val Val Xaa Glu Xaa Lys Xaa 
    210                 215                 220                 


Val Glu Leu Val Ile Val Ala Asp His Ser Glu Ala Gln Lys Tyr Arg 
225                 230                 235                 240 


Asp Phe Gln His Leu Leu Asn Arg Xaa Leu Glu Val Ala Leu Leu Leu 
                245                 250                 255     


Asp Xaa Phe Phe Arg Pro Leu Asn Val Arg Val Ala Leu Val Gly Leu 
            260                 265                 270         


Glu Ala Trp Xaa Gln Arg Asp Leu Val Glu Ile Ser Pro Asn Pro Ala 
        275                 280                 285             


Val Xaa Leu Glu Asn Phe Leu His Trp Arg Arg Ala His Leu Leu Pro 
    290                 295                 300                 


Arg Leu Pro His Asp Ser Ala Gln Leu Val Xaa Gly Xaa Ser Phe Ser 
305                 310                 315                 320 


Gly Pro Xaa Val Gly Met Ala Ile Gln Asn Ser Ile Cys Ser Pro Asp 
                325                 330                 335     


Phe Ser Gly Gly Val Asn Met Asp His Ser Xaa Ser Ile Leu Gly Val 
            340                 345                 350         


Ala Ser Ser Ile Ala His Glu Leu Gly His Ser Leu Gly Leu Asp His 
        355                 360                 365             


Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro Gly Pro Ala Pro Ala Lys 
    370                 375                 380                 


Xaa Cys Ile Met Glu Ala Ser Xaa Asp Phe Leu Pro Gly Leu Asn Phe 
385                 390                 395                 400 


Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys Ala Leu Leu Asp Gly Met 
                405                 410                 415     


Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser Leu Pro Pro Met Ala Ala 
            420                 425                 430         


Phe Cys Gly Asn Met Phe Val Glu Pro Gly Glu Gln Cys Asp Cys Gly 
        435                 440                 445             


Phe Leu Asp Asp Cys Val Asp Pro Cys Cys Asp Ser Leu Xaa Cys Gln 
    450                 455                 460                 


Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp Gly Pro Cys Cys Gln Asn 
465                 470                 475                 480 


Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys Arg Pro Xaa Arg Gly Asp 
                485                 490                 495     


Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp Ser Ser Gln Cys Pro Pro 
            500                 505                 510         


Asp Val Ser Leu Gly Asp Gly Glu Pro Cys Ala Gly Gly Gln Ala Val 
        515                 520                 525             


Cys Met His Gly Arg Cys Ala Ser Tyr Ala Gln Gln Cys Gln Ser Leu 
    530                 535                 540                 


Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro Leu Cys Leu Gln Xaa Ala 
545                 550                 555                 560 


Asn Xaa Arg Gly Asn Ala Phe Gly Ser Cys Gly Arg Asn Pro Ser Gly 
                565                 570                 575     


Ser Tyr Val Ser Cys Xaa Pro Arg Asp Ala Ile Cys Gly Gln Leu Gln 
            580                 585                 590         


Cys Gln Xaa Gly Arg Xaa Gln Pro Leu Leu Gly Ser Ile Arg Asp Leu 
        595                 600                 605             


Leu Trp Glu Xaa Ile Asp Val Asn Gly Xaa Glu Leu Asn Cys Ser Trp 
    610                 615                 620                 


Val His Leu Asp Leu Gly Ser Asp Val Ala Gln Pro Leu Leu Xaa Leu 
625                 630                 635                 640 


Pro Gly Xaa Ala Cys Gly Pro Gly Leu Val Cys Ile Asp His Arg Cys 
                645                 650                 655     


Gln Arg Val Asp Leu Leu Gly Ala Gln Glu Cys Arg Ser Lys Cys His 
            660                 665                 670         


Gly His Gly Val Cys Asp Ser Asn Arg His Cys Tyr Cys Glu Glu Gly 
        675                 680                 685             


Trp Ala Pro Pro Asp Cys Xaa Xaa Gln Leu Lys Ala Xaa Ser Ser Leu 
    690                 695                 700                 


Xaa Xaa Gly Leu Leu Leu Ser Leu Leu Val Leu Leu Val Leu Val Met 
705                 710                 715                 720 


Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg Leu His Gln Arg Leu Cys 
                725                 730                 735     


Gln Leu Lys Gly Pro Xaa Cys Gln Tyr Arg Ala Ala Gln Ser Gly Pro 
            740                 745                 750         


Ser Glu Arg Pro Gly Pro Pro Gln Arg Ala Leu Leu Ala Arg Gly Xaa 
        755                 760                 765             


Lys Ser Gln Gly Pro Ala Lys Pro Pro Pro Pro Arg Lys Pro Leu Pro 
    770                 775                 780                 


Ala Asp Pro Gln Gly Arg Cys Pro Ser Gly Asp Leu Pro Gly Pro Gly 
785                 790                 795                 800 


Ala Gly Ile Pro Pro Leu Val Val Pro Ser Arg Pro Ala Pro Pro Pro 
                805                 810                 815     


Pro Xaa Val Ser Ser Leu Tyr Leu 
            820                 


<210> 1483
<211> 633
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<400> 1483
Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Val Ser Ala Cys Asn Val 
            20                  25                  30          


Glu Ala Pro Gln Val Ala Leu Arg Ser Ser Arg Gln Ser Gln Arg Arg 
        35                  40                  45              


Pro Arg Gly Ser Pro Trp Ser Pro Arg Ser Phe Arg Xaa Ile Ser Gln 
    50                  55                  60                  


Leu Ala Ser Lys Arg Cys Phe Arg Glu Leu Val Pro Gly Arg Pro Xaa 
65                  70                  75                  80  


Leu Val Trp Tyr Gln Pro Asp Gly Xaa Arg Val Val Ser Glu Gly His 
                85                  90                  95      


Xaa Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
            100                 105                 110         


Ser Trp Val Ser Ile Cys Xaa Cys Ser Gly Leu Arg Gly Leu Val Val 
        115                 120                 125             


Leu Xaa Pro Glu Arg Ser Tyr Xaa Leu Glu Gln Gly Pro Gly Asp Leu 
    130                 135                 140                 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
145                 150                 155                 160 


His Xaa Cys Ala Leu Ser Trp Arg Glu Ser Val His Xaa Gln Lys Pro 
                165                 170                 175     


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
            180                 185                 190         


Val Xaa Glu Xaa Lys Xaa Val Glu Leu Val Ile Val Ala Asp His Ser 
        195                 200                 205             


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Xaa Leu 
    210                 215                 220                 


Glu Val Ala Leu Leu Leu Asp Xaa Phe Phe Arg Pro Leu Asn Val Arg 
225                 230                 235                 240 


Val Ala Leu Val Gly Leu Glu Ala Trp Xaa Gln Arg Asp Leu Val Glu 
                245                 250                 255     


Ile Ser Pro Asn Pro Ala Val Xaa Leu Glu Asn Phe Leu His Trp Arg 
            260                 265                 270         


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
        275                 280                 285             


Xaa Gly Xaa Ser Phe Ser Gly Pro Xaa Val Gly Met Ala Ile Gln Asn 
    290                 295                 300                 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
305                 310                 315                 320 


Xaa Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
                325                 330                 335     


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
            340                 345                 350         


Gly Pro Ala Pro Ala Lys Xaa Cys Ile Met Glu Ala Ser Xaa Asp Phe 
        355                 360                 365             


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
    370                 375                 380                 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
385                 390                 395                 400 


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
                405                 410                 415     


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
            420                 425                 430         


Asp Ser Leu Xaa Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
        435                 440                 445             


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
    450                 455                 460                 


Arg Pro Xaa Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
465                 470                 475                 480 


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
                485                 490                 495     


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
            500                 505                 510         


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
        515                 520                 525             


Leu Cys Leu Gln Xaa Ala Asn Xaa Arg Gly Asn Ala Phe Gly Ser Cys 
    530                 535                 540                 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Xaa Pro Arg Asp Ala 
545                 550                 555                 560 


Ile Cys Gly Gln Leu Gln Cys Gln Xaa Gly Arg Xaa Gln Pro Leu Leu 
                565                 570                 575     


Gly Ser Ile Arg Asp Leu Leu Trp Glu Xaa Ile Asp Val Asn Gly Xaa 
            580                 585                 590         


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
        595                 600                 605             


Gln Pro Leu Leu Xaa Leu Pro Gly Xaa Ala Cys Gly Pro Gly Leu Val 
    610                 615                 620                 


Ser Ser Leu Gly Gly Gln Asp Gln Val 
625                 630             


<210> 1484
<211> 285
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<400> 1484
Met Arg Gln Ser Leu Leu Phe Leu Xaa Ser Val Val Pro Phe Val Leu 
1               5                   10                  15      


Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
            20                  25                  30          


Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
        35                  40                  45              


Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Xaa Ser Xaa 
    50                  55                  60                  


His Val Glu Xaa Leu Leu Xaa Phe Ser Ala Leu Lys Arg His Phe Lys 
65                  70                  75                  80  


Leu Tyr Leu Xaa Ser Ser Xaa Glu Arg Phe Ser Gln Asn Phe Lys Val 
                85                  90                  95      


Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Xaa Val Lys Trp Gln 
            100                 105                 110         


Asp Phe Phe Xaa Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
        115                 120                 125             


Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Xaa Asp Gly 
    130                 135                 140                 


Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Xaa Lys 
145                 150                 155                 160 


Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                165                 170                 175     


Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
            180                 185                 190         


Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
        195                 200                 205             


Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Xaa 
    210                 215                 220                 


Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
225                 230                 235                 240 


Arg Gly Glu Glu Ser Xaa Xaa Xaa Asn Tyr Leu Ile Glu Leu Ile Asp 
                245                 250                 255     


Arg Val Asp Asp Ile Tyr Arg Asn Xaa Ser Trp Asp Asn Ala Gly Phe 
            260                 265                 270         


Lys Gly Tyr Gly Ile Gln Ile Glu Gln Leu Leu Phe Glu 
        275                 280                 285 


<210> 1485
<211> 824
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<400> 1485
Met Arg Gln Ser Leu Leu Phe Leu Xaa Ser Val Val Pro Phe Val Leu 
1               5                   10                  15      


Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
            20                  25                  30          


Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
        35                  40                  45              


Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Xaa Ser Xaa 
    50                  55                  60                  


His Val Glu Xaa Leu Leu Xaa Phe Ser Ala Leu Lys Arg His Phe Lys 
65                  70                  75                  80  


Leu Tyr Leu Xaa Ser Ser Xaa Glu Arg Phe Ser Gln Asn Phe Lys Val 
                85                  90                  95      


Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Xaa Val Lys Trp Gln 
            100                 105                 110         


Asp Phe Phe Xaa Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
        115                 120                 125             


Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Xaa Asp Gly 
    130                 135                 140                 


Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Xaa Lys 
145                 150                 155                 160 


Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                165                 170                 175     


Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
            180                 185                 190         


Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
        195                 200                 205             


Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Xaa 
    210                 215                 220                 


Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
225                 230                 235                 240 


Arg Gly Glu Glu Ser Xaa Xaa Xaa Asn Tyr Leu Ile Glu Leu Ile Asp 
                245                 250                 255     


Arg Val Asp Asp Ile Tyr Arg Asn Xaa Ser Trp Asp Asn Ala Gly Phe 
            260                 265                 270         


Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
        275                 280                 285             


Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr 
    290                 295                 300                 


Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
305                 310                 315                 320 


Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                325                 330                 335     


Leu Phe Xaa Tyr Gln Asp Phe Asp Met Gly Xaa Leu Gly Leu Ala Tyr 
            340                 345                 350         


Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
        355                 360                 365             


Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
    370                 375                 380                 


Xaa Ser Xaa Lys Asn Tyr Gly Lys Xaa Ile Leu Xaa Lys Glu Ala Asp 
385                 390                 395                 400 


Leu Val Xaa Xaa His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                405                 410                 415     


Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
            420                 425                 430         


Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
        435                 440                 445             


Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Xaa Ile Glu Ser 
    450                 455                 460                 


Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
465                 470                 475                 480 


Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                485                 490                 495     


Asn Asn Asp Xaa Cys Cys Asn Ser Asp Cys Xaa Leu Lys Glu Gly Val 
            500                 505                 510         


Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
        515                 520                 525             


Xaa Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Xaa Cys Lys Gly 
    530                 535                 540                 


Val Ser Tyr Cys Xaa Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn 
545                 550                 555                 560 


Ala Glu Asp Asp Xaa Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly 
                565                 570                 575     


Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala 
            580                 585                 590         


Cys Asn Glu Xaa Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser 
        595                 600                 605             


Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
    610                 615                 620                 


Arg Lys Gly Lys Pro Cys Xaa Val Gly Phe Cys Asp Met Asn Gly Lys 
625                 630                 635                 640 


Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                645                 650                 655     


Asp Gln Leu Ser Ile Asn Xaa Phe Gly Lys Phe Leu Ala Asp Asn Ile 
            660                 665                 670         


Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
        675                 680                 685             


Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
    690                 695                 700                 


Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp 
705                 710                 715                 720 


Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Xaa Pro 
                725                 730                 735     


Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro 
            740                 745                 750         


Lys Leu Asp His Gln Arg Met Asp Xaa Ile Gln Glu Asp Pro Ser Xaa 
        755                 760                 765             


Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn 
    770                 775                 780                 


Ser Ser Xaa Ala Ala Lys Ser Phe Glu Asp Leu Xaa Asp His Pro Val 
785                 790                 795                 800 


Xaa Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg 
                805                 810                 815     


Val Asp Ser Lys Glu Xaa Glu Cys 
            820                 


<210> 1486
<211> 258
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<400> 1486
Met Arg Gln Ser Leu Leu Phe Leu Xaa Ser Val Val Pro Phe Val Leu 
1               5                   10                  15      


Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
            20                  25                  30          


Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
        35                  40                  45              


Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Xaa Ser Xaa 
    50                  55                  60                  


His Val Glu Xaa Leu Leu Xaa Phe Ser Ala Leu Lys Arg His Phe Lys 
65                  70                  75                  80  


Leu Tyr Leu Xaa Ser Ser Xaa Glu Arg Phe Ser Gln Asn Phe Lys Val 
                85                  90                  95      


Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Xaa Val Lys Trp Gln 
            100                 105                 110         


Asp Phe Phe Xaa Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
        115                 120                 125             


Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Xaa Asp Gly 
    130                 135                 140                 


Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Xaa Lys 
145                 150                 155                 160 


Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                165                 170                 175     


Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
            180                 185                 190         


Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
        195                 200                 205             


Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Xaa 
    210                 215                 220                 


Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
225                 230                 235                 240 


Arg Gly Glu Glu Ser Xaa Xaa Xaa Asn Tyr Leu Ile His Xaa Asp Arg 
                245                 250                 255     


Ala Asn 
        


<210> 1487
<211> 579
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<400> 1487
Met Trp Arg Val Leu Phe Leu Leu Ser Gly Leu Gly Gly Leu Arg Met 
1               5                   10                  15      


Asp Ser Asn Phe Asp Ser Leu Pro Val Gln Ile Xaa Val Pro Glu Lys 
            20                  25                  30          


Ile Arg Ser Ile Ile Lys Glu Gly Ile Glu Ser Gln Ala Ser Tyr Lys 
        35                  40                  45              


Ile Val Ile Glu Gly Lys Pro Tyr Xaa Val Asn Leu Met Gln Lys Asn 
    50                  55                  60                  


Phe Leu Pro His Asn Phe Arg Val Tyr Ser Tyr Ser Gly Xaa Gly Ile 
65                  70                  75                  80  


Met Lys Pro Leu Asp Gln Asp Phe Gln Asn Phe Cys His Tyr Gln Gly 
                85                  90                  95      


Tyr Ile Glu Gly Tyr Pro Lys Ser Val Val Met Val Ser Xaa Cys Xaa 
            100                 105                 110         


Gly Leu Arg Gly Val Leu Gln Phe Glu Asn Val Ser Tyr Gly Ile Glu 
        115                 120                 125             


Pro Leu Glu Ser Ser Val Gly Phe Glu His Val Ile Tyr Gln Val Lys 
    130                 135                 140                 


His Lys Lys Ala Asp Val Ser Leu Tyr Asn Glu Lys Asp Ile Glu Ser 
145                 150                 155                 160 


Arg Asp Leu Ser Phe Lys Leu Gln Ser Val Glu His Pro Arg Xaa Ile 
                165                 170                 175     


Ser Leu Glu Ser Leu Ala Val Ile Leu Ala Gln Leu Leu Ser Leu Ser 
            180                 185                 190         


Met Gly Ile Xaa Tyr Asp Asp Ile Asn Lys Cys Gln Cys Ser Gly Ala 
        195                 200                 205             


Val Cys Ile Met Asn Pro Glu Ala Ile His Phe Ser Gly Val Lys Ile 
    210                 215                 220                 


Phe Ser Asn Cys Ser Phe Glu Asp Phe Ala His Phe Ile Ser Lys Gln 
225                 230                 235                 240 


Lys Ser Gln Cys Leu His Asn Gln Pro Arg Leu Asp Pro Phe Phe Lys 
                245                 250                 255     


Gln Gln Ala Val Cys Gly Asn Ala Lys Leu Glu Ala Gly Glu Glu Cys 
            260                 265                 270         


Asp Cys Gly Xaa Glu Gln Asp Cys Ala Leu Ile Gly Glu Xaa Cys Cys 
        275                 280                 285             


Asp Ile Ala Xaa Cys Arg Phe Lys Ala Gly Ser Asn Cys Ala Glu Gly 
    290                 295                 300                 


Pro Cys Cys Glu Asn Cys Leu Phe Met Ser Lys Glu Arg Met Cys Arg 
305                 310                 315                 320 


Pro Ser Phe Glu Glu Cys Asp Leu Pro Glu Tyr Cys Asn Gly Ser Ser 
                325                 330                 335     


Ala Ser Cys Pro Glu Asn His Tyr Val Gln Xaa Gly His Pro Cys Gly 
            340                 345                 350         


Leu Asn Gln Trp Ile Cys Ile Asp Gly Val Cys Met Ser Gly Asp Lys 
        355                 360                 365             


Gln Cys Xaa Asp Xaa Phe Gly Lys Glu Val Glu Phe Gly Pro Ser Glu 
    370                 375                 380                 


Cys Tyr Ser His Leu Asn Ser Lys Xaa Asp Val Ser Gly Asn Cys Gly 
385                 390                 395                 400 


Ile Ser Asp Ser Gly Tyr Xaa Gln Cys Glu Ala Asp Gly His Leu Cys 
                405                 410                 415     


Ile Ala Val Glu Phe Ala Ser Asp His Ala Asp Ser Gln Lys Met Trp 
            420                 425                 430         


Ile Lys Asp Gly Xaa Ser Cys Gly Ser Asn Lys Val Cys Arg Asn Gln 
        435                 440                 445             


Arg Cys Val Ser Ser Ser Tyr Leu Gly Tyr Asp Cys Xaa Xaa Asp Lys 
    450                 455                 460                 


Cys Asn Asp Arg Gly Val Cys Asn Asn Lys Lys His Cys His Cys Ser 
465                 470                 475                 480 


Ala Ser Tyr Leu Pro Pro Asp Cys Ser Val Gln Ser Asp Leu Trp Pro 
                485                 490                 495     


Gly Gly Ser Ile Asp Ser Gly Asn Phe Pro Pro Val Ala Ile Pro Ala 
            500                 505                 510         


Arg Leu Pro Glu Arg Arg Tyr Ile Glu Asn Ile Tyr His Ser Lys Pro 
        515                 520                 525             


Met Arg Trp Pro Phe Phe Leu Phe Ile Pro Phe Phe Ile Ile Phe Cys 
    530                 535                 540                 


Val Leu Ile Ala Ile Met Val Lys Val Asn Phe Gln Arg Lys Lys Trp 
545                 550                 555                 560 


Arg Xaa Glu Asp Tyr Ser Ser Asp Glu Gln Pro Glu Ser Glu Ser Glu 
                565                 570                 575     


Pro Lys Gly 
            


<210> 1488
<211> 672
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<400> 1488
Met Trp Arg Val Leu Phe Leu Leu Ser Gly Leu Gly Gly Leu Arg Met 
1               5                   10                  15      


Asp Ser Asn Phe Asp Ser Leu Pro Val Gln Ile Xaa Val Pro Glu Lys 
            20                  25                  30          


Ile Arg Ser Ile Ile Lys Glu Gly Ile Glu Ser Gln Ala Ser Tyr Lys 
        35                  40                  45              


Ile Val Ile Glu Gly Lys Pro Tyr Xaa Val Asn Leu Met Gln Lys Asn 
    50                  55                  60                  


Phe Leu Pro His Asn Phe Arg Val Tyr Ser Tyr Ser Gly Xaa Gly Ile 
65                  70                  75                  80  


Met Lys Pro Leu Asp Gln Asp Phe Gln Asn Phe Cys His Tyr Gln Gly 
                85                  90                  95      


Tyr Ile Glu Gly Tyr Pro Lys Ser Val Val Met Val Ser Xaa Cys Xaa 
            100                 105                 110         


Gly Leu Arg Gly Val Leu Gln Phe Glu Asn Val Ser Tyr Gly Ile Glu 
        115                 120                 125             


Pro Leu Glu Ser Ser Val Gly Phe Glu His Val Ile Tyr Gln Val Lys 
    130                 135                 140                 


His Lys Lys Ala Asp Val Ser Leu Tyr Asn Glu Lys Asp Ile Glu Ser 
145                 150                 155                 160 


Arg Asp Leu Ser Phe Lys Leu Gln Ser Val Glu Pro Gln Gln Asp Phe 
                165                 170                 175     


Ala Lys Tyr Ile Glu Met His Val Ile Val Glu Lys Gln Leu Tyr Asn 
            180                 185                 190         


His Met Gly Ser Asp Xaa Xaa Val Val Ala Gln Lys Val Phe Gln Leu 
        195                 200                 205             


Ile Gly Leu Xaa Asn Ala Ile Phe Val Ser Phe Asn Ile Xaa Ile Ile 
    210                 215                 220                 


Leu Ser Ser Leu Glu Leu Trp Ile Asp Glu Asn Lys Ile Ala Xaa Xaa 
225                 230                 235                 240 


Gly Glu Ala Asn Glu Leu Leu His Xaa Phe Leu Arg Trp Lys Xaa Ser 
                245                 250                 255     


Tyr Leu Val Leu Arg Pro His Asp Val Ala Phe Leu Leu Val Tyr Arg 
            260                 265                 270         


Glu Lys Ser Asn Tyr Val Gly Ala Xaa Phe Gln Gly Lys Met Cys Asp 
        275                 280                 285             


Ala Asn Tyr Ala Gly Gly Val Val Leu His Pro Arg Xaa Ile Ser Leu 
    290                 295                 300                 


Glu Ser Leu Ala Val Ile Leu Ala Gln Leu Leu Ser Leu Ser Met Gly 
305                 310                 315                 320 


Ile Xaa Tyr Asp Asp Ile Asn Lys Cys Gln Cys Ser Gly Ala Val Cys 
                325                 330                 335     


Ile Met Asn Pro Glu Ala Ile His Phe Ser Gly Val Lys Ile Phe Ser 
            340                 345                 350         


Asn Cys Ser Phe Glu Asp Phe Ala His Phe Ile Ser Lys Gln Lys Ser 
        355                 360                 365             


Gln Cys Leu His Asn Gln Pro Arg Leu Asp Pro Phe Phe Lys Gln Gln 
    370                 375                 380                 


Ala Val Cys Gly Asn Ala Lys Leu Glu Ala Gly Glu Glu Cys Asp Cys 
385                 390                 395                 400 


Gly Xaa Glu Gln Asp Cys Ala Leu Ile Gly Glu Xaa Cys Cys Asp Ile 
                405                 410                 415     


Ala Xaa Cys Arg Phe Lys Ala Gly Ser Asn Cys Ala Glu Gly Pro Cys 
            420                 425                 430         


Cys Glu Asn Cys Leu Phe Met Ser Lys Glu Arg Met Cys Arg Pro Ser 
        435                 440                 445             


Phe Glu Glu Cys Asp Leu Pro Glu Tyr Cys Asn Gly Ser Ser Ala Ser 
    450                 455                 460                 


Cys Pro Glu Asn His Tyr Val Gln Xaa Gly His Pro Cys Gly Leu Asn 
465                 470                 475                 480 


Gln Trp Ile Cys Ile Asp Gly Val Cys Met Ser Gly Asp Lys Gln Cys 
                485                 490                 495     


Xaa Asp Xaa Phe Gly Lys Glu Val Glu Phe Gly Pro Ser Glu Cys Tyr 
            500                 505                 510         


Ser His Leu Asn Ser Lys Xaa Asp Val Ser Gly Asn Cys Gly Ile Ser 
        515                 520                 525             


Asp Ser Gly Tyr Xaa Gln Cys Glu Val Cys Arg Asn Gln Arg Cys Val 
    530                 535                 540                 


Ser Ser Ser Tyr Leu Gly Tyr Asp Cys Xaa Xaa Asp Lys Cys Asn Asp 
545                 550                 555                 560 


Arg Gly Val Cys Asn Asn Lys Lys His Cys His Cys Ser Ala Ser Tyr 
                565                 570                 575     


Leu Pro Pro Asp Cys Ser Val Gln Ser Asp Leu Trp Pro Gly Gly Ser 
            580                 585                 590         


Ile Asp Ser Gly Asn Phe Pro Pro Val Ala Ile Pro Ala Arg Leu Pro 
        595                 600                 605             


Glu Arg Arg Tyr Ile Glu Asn Ile Tyr His Ser Lys Pro Met Arg Trp 
    610                 615                 620                 


Pro Phe Phe Leu Phe Ile Pro Phe Phe Ile Ile Phe Cys Val Leu Ile 
625                 630                 635                 640 


Ala Ile Met Val Lys Val Asn Phe Gln Arg Lys Lys Trp Arg Xaa Glu 
                645                 650                 655     


Asp Tyr Ser Ser Asp Glu Gln Pro Glu Ser Glu Ser Glu Pro Lys Gly 
            660                 665                 670         


<210> 1489
<211> 735
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<400> 1489
Met Trp Arg Val Leu Phe Leu Leu Ser Gly Leu Gly Gly Leu Arg Met 
1               5                   10                  15      


Asp Ser Asn Phe Asp Ser Leu Pro Val Gln Ile Xaa Val Pro Glu Lys 
            20                  25                  30          


Ile Arg Ser Ile Ile Lys Glu Gly Ile Glu Ser Gln Ala Ser Tyr Lys 
        35                  40                  45              


Ile Val Ile Glu Gly Lys Pro Tyr Xaa Val Asn Leu Met Gln Lys Asn 
    50                  55                  60                  


Phe Leu Pro His Asn Phe Arg Val Tyr Ser Tyr Ser Gly Xaa Gly Ile 
65                  70                  75                  80  


Met Lys Pro Leu Asp Gln Asp Phe Gln Asn Phe Cys His Tyr Gln Gly 
                85                  90                  95      


Tyr Ile Glu Gly Tyr Pro Lys Ser Val Val Met Val Ser Xaa Cys Xaa 
            100                 105                 110         


Gly Leu Arg Gly Val Leu Gln Phe Glu Asn Val Ser Tyr Gly Ile Glu 
        115                 120                 125             


Pro Leu Glu Ser Ser Val Gly Phe Glu His Val Ile Tyr Gln Val Lys 
    130                 135                 140                 


His Lys Lys Ala Asp Val Ser Leu Tyr Asn Glu Lys Asp Ile Glu Ser 
145                 150                 155                 160 


Arg Asp Leu Ser Phe Lys Leu Gln Ser Val Glu Pro Gln Gln Asp Phe 
                165                 170                 175     


Ala Lys Tyr Ile Glu Met His Val Ile Val Glu Lys Gln Leu Tyr Asn 
            180                 185                 190         


His Met Gly Ser Asp Xaa Xaa Val Val Ala Gln Lys Val Phe Gln Leu 
        195                 200                 205             


Ile Gly Leu Xaa Asn Ala Ile Phe Val Ser Phe Asn Ile Xaa Ile Ile 
    210                 215                 220                 


Leu Ser Ser Leu Glu Leu Trp Ile Asp Glu Asn Lys Ile Ala Xaa Xaa 
225                 230                 235                 240 


Gly Glu Ala Asn Glu Leu Leu His Xaa Phe Leu Arg Trp Lys Xaa Ser 
                245                 250                 255     


Tyr Leu Val Leu Arg Pro His Asp Val Ala Phe Leu Leu Val Tyr Arg 
            260                 265                 270         


Glu Lys Ser Asn Tyr Val Gly Ala Xaa Phe Gln Gly Lys Met Cys Asp 
        275                 280                 285             


Ala Asn Tyr Ala Gly Gly Val Val Leu His Pro Arg Xaa Ile Ser Leu 
    290                 295                 300                 


Glu Ser Leu Ala Val Ile Leu Ala Gln Leu Leu Ser Leu Ser Met Gly 
305                 310                 315                 320 


Ile Xaa Tyr Asp Asp Ile Asn Lys Cys Gln Cys Ser Gly Ala Val Cys 
                325                 330                 335     


Ile Met Asn Pro Glu Ala Ile His Phe Ser Gly Val Lys Ile Phe Ser 
            340                 345                 350         


Asn Cys Ser Phe Glu Asp Phe Ala His Phe Ile Ser Lys Gln Lys Ser 
        355                 360                 365             


Gln Cys Leu His Asn Gln Pro Arg Leu Asp Pro Phe Phe Lys Gln Gln 
    370                 375                 380                 


Ala Val Cys Gly Asn Ala Lys Leu Glu Ala Gly Glu Glu Cys Asp Cys 
385                 390                 395                 400 


Gly Xaa Glu Gln Asp Cys Ala Leu Ile Gly Glu Xaa Cys Cys Asp Ile 
                405                 410                 415     


Ala Xaa Cys Arg Phe Lys Ala Gly Ser Asn Cys Ala Glu Gly Pro Cys 
            420                 425                 430         


Cys Glu Asn Cys Leu Phe Met Ser Lys Glu Arg Met Cys Arg Pro Ser 
        435                 440                 445             


Phe Glu Glu Cys Asp Leu Pro Glu Tyr Cys Asn Gly Ser Ser Ala Ser 
    450                 455                 460                 


Cys Pro Glu Asn His Tyr Val Gln Xaa Gly His Pro Cys Gly Leu Asn 
465                 470                 475                 480 


Gln Trp Ile Cys Ile Asp Gly Val Cys Met Ser Gly Asp Lys Gln Cys 
                485                 490                 495     


Xaa Asp Xaa Phe Gly Lys Glu Val Glu Phe Gly Pro Ser Glu Cys Tyr 
            500                 505                 510         


Ser His Leu Asn Ser Lys Xaa Asp Val Ser Gly Asn Cys Gly Ile Ser 
        515                 520                 525             


Asp Ser Gly Tyr Xaa Gln Cys Glu Ala Asp Asn Leu Gln Cys Gly Lys 
    530                 535                 540                 


Leu Ile Cys Lys Tyr Val Gly Lys Phe Leu Leu Gln Ile Pro Arg Ala 
545                 550                 555                 560 


Xaa Ile Ile Tyr Ala Asn Ile Ser Gly His Leu Cys Ile Ala Val Glu 
                565                 570                 575     


Phe Ala Ser Asp His Ala Asp Ser Gln Lys Met Trp Ile Lys Asp Gly 
            580                 585                 590         


Xaa Ser Cys Gly Ser Asn Lys Val Cys Arg Asn Gln Arg Cys Val Ser 
        595                 600                 605             


Ser Ser Tyr Leu Gly Tyr Asp Cys Xaa Xaa Asp Lys Cys Asn Asp Arg 
    610                 615                 620                 


Gly Val Cys Asn Asn Lys Lys His Cys His Cys Ser Ala Ser Tyr Leu 
625                 630                 635                 640 


Pro Pro Asp Cys Ser Val Gln Ser Asp Leu Trp Pro Gly Gly Ser Ile 
                645                 650                 655     


Asp Ser Gly Asn Phe Pro Pro Val Ala Ile Pro Ala Arg Leu Pro Glu 
            660                 665                 670         


Arg Arg Tyr Ile Glu Asn Ile Tyr His Ser Lys Pro Met Arg Trp Pro 
        675                 680                 685             


Phe Phe Leu Phe Ile Pro Phe Phe Ile Ile Phe Cys Val Leu Ile Ala 
    690                 695                 700                 


Ile Met Val Lys Val Asn Phe Gln Arg Lys Lys Trp Arg Xaa Glu Asp 
705                 710                 715                 720 


Tyr Ser Ser Asp Glu Gln Pro Glu Ser Glu Ser Glu Pro Lys Gly 
                725                 730                 735 


<210> 1490
<211> 716
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<400> 1490
Met Trp Arg Val Leu Phe Leu Leu Ser Gly Leu Gly Gly Leu Arg Met 
1               5                   10                  15      


Asp Ser Asn Phe Asp Ser Leu Pro Val Gln Ile Xaa Val Pro Glu Lys 
            20                  25                  30          


Ile Arg Ser Ile Ile Lys Glu Gly Ile Glu Ser Gln Ala Ser Tyr Lys 
        35                  40                  45              


Ile Val Ile Glu Gly Lys Pro Tyr Xaa Val Asn Leu Met Gln Lys Asn 
    50                  55                  60                  


Phe Leu Pro His Asn Phe Arg Val Tyr Ser Tyr Ser Gly Xaa Gly Ile 
65                  70                  75                  80  


Met Lys Pro Leu Asp Gln Asp Phe Gln Asn Phe Cys His Tyr Gln Gly 
                85                  90                  95      


Tyr Ile Glu Gly Tyr Pro Lys Ser Val Val Met Val Ser Xaa Cys Xaa 
            100                 105                 110         


Gly Leu Arg Gly Val Leu Gln Phe Glu Asn Val Ser Tyr Gly Ile Glu 
        115                 120                 125             


Pro Leu Glu Ser Ser Val Gly Phe Glu His Val Ile Tyr Gln Val Lys 
    130                 135                 140                 


His Lys Lys Ala Asp Val Ser Leu Tyr Asn Glu Lys Asp Ile Glu Ser 
145                 150                 155                 160 


Arg Asp Leu Ser Phe Lys Leu Gln Ser Val Glu Tyr Asn His Met Gly 
                165                 170                 175     


Ser Asp Xaa Xaa Val Val Ala Gln Lys Val Phe Gln Leu Ile Gly Leu 
            180                 185                 190         


Xaa Asn Ala Ile Phe Val Ser Phe Asn Ile Xaa Ile Ile Leu Ser Ser 
        195                 200                 205             


Leu Glu Leu Trp Ile Asp Glu Asn Lys Ile Ala Xaa Xaa Gly Glu Ala 
    210                 215                 220                 


Asn Glu Leu Leu His Xaa Phe Leu Arg Trp Lys Xaa Ser Tyr Leu Val 
225                 230                 235                 240 


Leu Arg Pro His Asp Val Ala Phe Leu Leu Val Tyr Arg Glu Lys Ser 
                245                 250                 255     


Asn Tyr Val Gly Ala Xaa Phe Gln Gly Lys Met Cys Asp Ala Asn Tyr 
            260                 265                 270         


Ala Gly Gly Val Val Leu His Pro Arg Xaa Ile Ser Leu Glu Ser Leu 
        275                 280                 285             


Ala Val Ile Leu Ala Gln Leu Leu Ser Leu Ser Met Gly Ile Xaa Tyr 
    290                 295                 300                 


Asp Asp Ile Asn Lys Cys Gln Cys Ser Gly Ala Val Cys Ile Met Asn 
305                 310                 315                 320 


Pro Glu Ala Ile His Phe Ser Gly Val Lys Ile Phe Ser Asn Cys Ser 
                325                 330                 335     


Phe Glu Asp Phe Ala His Phe Ile Ser Lys Gln Lys Ser Gln Cys Leu 
            340                 345                 350         


His Asn Gln Pro Arg Leu Asp Pro Phe Phe Lys Gln Gln Ala Val Cys 
        355                 360                 365             


Gly Asn Ala Lys Leu Glu Ala Gly Glu Glu Cys Asp Cys Gly Xaa Glu 
    370                 375                 380                 


Gln Asp Cys Ala Leu Ile Gly Glu Xaa Cys Cys Asp Ile Ala Xaa Cys 
385                 390                 395                 400 


Arg Phe Lys Ala Gly Ser Asn Cys Ala Glu Gly Pro Cys Cys Glu Asn 
                405                 410                 415     


Cys Leu Phe Met Ser Lys Glu Arg Met Cys Arg Pro Ser Phe Glu Glu 
            420                 425                 430         


Cys Asp Leu Pro Glu Tyr Cys Asn Gly Ser Ser Ala Ser Cys Pro Glu 
        435                 440                 445             


Asn His Tyr Val Gln Xaa Gly His Pro Cys Gly Leu Asn Gln Trp Ile 
    450                 455                 460                 


Cys Ile Asp Gly Val Cys Met Ser Gly Asp Lys Gln Cys Xaa Asp Xaa 
465                 470                 475                 480 


Phe Gly Lys Glu Val Glu Phe Gly Pro Ser Glu Cys Tyr Ser His Leu 
                485                 490                 495     


Asn Ser Lys Xaa Asp Val Ser Gly Asn Cys Gly Ile Ser Asp Ser Gly 
            500                 505                 510         


Tyr Xaa Gln Cys Glu Ala Asp Asn Leu Gln Cys Gly Lys Leu Ile Cys 
        515                 520                 525             


Lys Tyr Val Gly Lys Phe Leu Leu Gln Ile Pro Arg Ala Xaa Ile Ile 
    530                 535                 540                 


Tyr Ala Asn Ile Ser Gly His Leu Cys Ile Ala Val Glu Phe Ala Ser 
545                 550                 555                 560 


Asp His Ala Asp Ser Gln Lys Met Trp Ile Lys Asp Gly Xaa Ser Cys 
                565                 570                 575     


Gly Ser Asn Lys Val Cys Arg Asn Gln Arg Cys Val Ser Ser Ser Tyr 
            580                 585                 590         


Leu Gly Tyr Asp Cys Xaa Xaa Asp Lys Cys Asn Asp Arg Gly Val Cys 
        595                 600                 605             


Asn Asn Lys Lys His Cys His Cys Ser Ala Ser Tyr Leu Pro Pro Asp 
    610                 615                 620                 


Cys Ser Val Gln Ser Asp Leu Trp Pro Gly Gly Ser Ile Asp Ser Gly 
625                 630                 635                 640 


Asn Phe Pro Pro Val Ala Ile Pro Ala Arg Leu Pro Glu Arg Arg Tyr 
                645                 650                 655     


Ile Glu Asn Ile Tyr His Ser Lys Pro Met Arg Trp Pro Phe Phe Leu 
            660                 665                 670         


Phe Ile Pro Phe Phe Ile Ile Phe Cys Val Leu Ile Ala Ile Met Val 
        675                 680                 685             


Lys Val Asn Phe Gln Arg Lys Lys Trp Arg Xaa Glu Asp Tyr Ser Ser 
    690                 695                 700                 


Asp Glu Gln Pro Glu Ser Glu Ser Glu Pro Lys Gly 
705                 710                 715     


<210> 1491
<211> 629
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<400> 1491
Met Phe Arg Leu Trp Leu Leu Leu Ala Gly Leu Cys Gly Leu Leu Ala 
1               5                   10                  15      


Ser Arg Pro Gly Phe Gln Asn Ser Leu Leu Gln Ile Val Ile Pro Glu 
            20                  25                  30          


Lys Ile Gln Xaa Asn Xaa Asn Asp Ser Ser Glu Ile Glu Tyr Glu Gln 
        35                  40                  45              


Ile Ser Tyr Ile Ile Pro Ile Asp Glu Lys Leu Tyr Xaa Val His Leu 
    50                  55                  60                  


Lys Gln Arg Tyr Phe Leu Ala Asp Asn Phe Met Ile Tyr Leu Tyr Asn 
65                  70                  75                  80  


Gln Gly Ser Met Asn Xaa Tyr Ser Ser Asp Ile Gln Xaa Gln Cys Tyr 
                85                  90                  95      


Tyr Gln Gly Asn Ile Glu Gly Tyr Pro Asp Ser Met Val Xaa Leu Ser 
            100                 105                 110         


Xaa Cys Ser Gly Leu Arg Gly Ile Leu Gln Phe Glu Asn Val Ser Tyr 
        115                 120                 125             


Gly Ile Glu Pro Leu Glu Ser Ala Val Glu Phe Gln His Val Leu Tyr 
    130                 135                 140                 


Lys Leu Lys Asn Glu Asp Asn Asp Ile Ala Ile Phe Ile Asp Arg Ser 
145                 150                 155                 160 


Leu Lys Glu Gln Pro Met Asp Asp Asn Ile Phe Ile Ser Glu Lys Ser 
                165                 170                 175     


Glu Pro Ala Val Pro Asp Leu Phe Pro Leu Tyr Leu Glu Met His Ile 
            180                 185                 190         


Val Val Asp Lys Xaa Leu Tyr Asp Tyr Trp Gly Ser Asp Ser Met Ile 
        195                 200                 205             


Val Xaa Asn Lys Val Ile Glu Ile Val Gly Leu Ala Asn Ser Met Phe 
    210                 215                 220                 


Xaa Gln Phe Lys Val Xaa Ile Val Leu Ser Ser Leu Glu Leu Trp Ser 
225                 230                 235                 240 


Asp Glu Asn Lys Ile Ser Xaa Val Gly Glu Ala Asp Glu Leu Leu Gln 
                245                 250                 255     


Lys Phe Leu Glu Trp Lys Gln Ser Tyr Leu Asn Leu Arg Pro His Asp 
            260                 265                 270         


Ile Ala Tyr Leu Leu Ile Tyr Met Asp Tyr Pro Arg Tyr Leu Gly Ala 
        275                 280                 285             


Val Phe Pro Gly Xaa Met Cys Ile Xaa Arg Tyr Ser Ala Gly Val Ala 
    290                 295                 300                 


Leu Gln Cys Gly Pro Ala Ser Cys Cys Asp Phe Arg Xaa Cys Val Leu 
305                 310                 315                 320 


Lys Asp Gly Ala Lys Cys Tyr Lys Gly Leu Cys Cys Lys Asp Cys Gln 
                325                 330                 335     


Ile Leu Gln Ser Gly Val Glu Cys Arg Pro Lys Ala His Pro Glu Cys 
            340                 345                 350         


Asp Ile Ala Glu Asn Cys Asn Gly Ser Ser Pro Glu Cys Gly Pro Asp 
        355                 360                 365             


Ile Xaa Leu Ile Asn Gly Leu Ser Cys Lys Asn Asn Lys Phe Ile Cys 
    370                 375                 380                 


Tyr Asp Gly Asp Cys His Asp Leu Asp Ala Arg Cys Glu Ser Val Phe 
385                 390                 395                 400 


Gly Lys Gly Ser Arg Asn Ala Pro Phe Ala Cys Tyr Glu Glu Ile Gln 
                405                 410                 415     


Ser Gln Ser Asp Arg Phe Gly Asn Cys Gly Arg Asp Arg Asn Asn Lys 
            420                 425                 430         


Tyr Val Phe Cys Gly Trp Arg Asn Leu Ile Cys Gly Arg Leu Val Cys 
        435                 440                 445             


Xaa Tyr Pro Xaa Arg Lys Pro Phe His Gln Glu Asn Gly Asp Val Ile 
    450                 455                 460                 


Tyr Ala Phe Val Arg Asp Ser Val Cys Ile Xaa Val Asp Tyr Lys Leu 
465                 470                 475                 480 


Pro Arg Xaa Val Pro Asp Pro Leu Ala Val Lys Asn Gly Ser Gln Cys 
                485                 490                 495     


Asp Ile Gly Arg Val Cys Val Asn Arg Glu Cys Val Glu Ser Arg Ile 
            500                 505                 510         


Ile Lys Ala Ser Ala His Val Cys Ser Gln Gln Cys Ser Gly His Gly 
        515                 520                 525             


Val Cys Asp Ser Arg Asn Lys Cys His Cys Ser Pro Gly Tyr Lys Pro 
    530                 535                 540                 


Pro Asn Cys Gln Ile Arg Ser Lys Gly Phe Ser Ile Phe Pro Glu Glu 
545                 550                 555                 560 


Asp Met Gly Ser Ile Met Glu Arg Ala Ser Gly Lys Xaa Glu Asn Xaa 
                565                 570                 575     


Trp Leu Leu Gly Phe Leu Ile Ala Leu Pro Ile Leu Ile Val Xaa Xaa 
            580                 585                 590         


Ala Ile Val Leu Ala Arg Lys Gln Leu Lys Lys Trp Phe Ala Lys Glu 
        595                 600                 605             


Glu Glu Phe Pro Ser Ser Glu Ser Lys Ser Gln Asp Ser Xaa Gln Xaa 
    610                 615                 620                 


Gln Ser Ser Ser Asn 
625                 


<210> 1492
<211> 787
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<400> 1492
Met Phe Arg Leu Trp Leu Leu Leu Ala Gly Leu Cys Gly Leu Leu Ala 
1               5                   10                  15      


Ser Arg Pro Gly Phe Gln Asn Ser Leu Leu Gln Ile Val Ile Pro Glu 
            20                  25                  30          


Lys Ile Gln Xaa Asn Xaa Asn Asp Ser Ser Glu Ile Glu Tyr Glu Gln 
        35                  40                  45              


Ile Ser Tyr Ile Ile Pro Ile Asp Glu Lys Leu Tyr Xaa Val His Leu 
    50                  55                  60                  


Lys Gln Arg Tyr Phe Leu Ala Asp Asn Phe Met Ile Tyr Leu Tyr Asn 
65                  70                  75                  80  


Gln Gly Ser Met Asn Xaa Tyr Ser Ser Asp Ile Gln Xaa Gln Cys Tyr 
                85                  90                  95      


Tyr Gln Gly Asn Ile Glu Gly Tyr Pro Asp Ser Met Val Xaa Leu Ser 
            100                 105                 110         


Xaa Cys Ser Gly Leu Arg Gly Ile Leu Gln Phe Glu Asn Val Ser Tyr 
        115                 120                 125             


Gly Ile Glu Pro Leu Glu Ser Ala Val Glu Phe Gln His Val Leu Tyr 
    130                 135                 140                 


Lys Leu Lys Asn Glu Asp Asn Asp Ile Ala Ile Phe Ile Asp Arg Ser 
145                 150                 155                 160 


Leu Lys Glu Gln Pro Met Asp Asp Asn Ile Phe Ile Ser Glu Lys Ser 
                165                 170                 175     


Glu Pro Ala Val Pro Asp Leu Phe Pro Leu Tyr Leu Glu Met His Ile 
            180                 185                 190         


Val Val Asp Lys Xaa Leu Tyr Asp Tyr Trp Gly Ser Asp Ser Met Ile 
        195                 200                 205             


Val Xaa Asn Lys Val Ile Glu Ile Val Gly Leu Ala Asn Ser Met Phe 
    210                 215                 220                 


Xaa Gln Phe Lys Val Xaa Ile Val Leu Ser Ser Leu Glu Leu Trp Ser 
225                 230                 235                 240 


Asp Glu Asn Lys Ile Ser Xaa Val Gly Glu Ala Asp Glu Leu Leu Gln 
                245                 250                 255     


Lys Phe Leu Glu Trp Lys Gln Ser Tyr Leu Asn Leu Arg Pro His Asp 
            260                 265                 270         


Ile Ala Tyr Leu Leu Ile Tyr Met Asp Tyr Pro Arg Tyr Leu Gly Ala 
        275                 280                 285             


Val Phe Pro Gly Xaa Met Cys Ile Xaa Arg Tyr Ser Ala Gly Val Ala 
    290                 295                 300                 


Leu Tyr Pro Lys Glu Ile Xaa Leu Glu Ala Phe Ala Val Ile Val Xaa 
305                 310                 315                 320 


Gln Met Leu Ala Leu Ser Leu Gly Ile Ser Tyr Asp Asp Pro Lys Lys 
                325                 330                 335     


Cys Gln Cys Ser Glu Ser Xaa Cys Ile Met Asn Pro Glu Val Val Gln 
            340                 345                 350         


Ser Asn Gly Val Lys Xaa Phe Ser Ser Cys Ser Leu Arg Ser Phe Gln 
        355                 360                 365             


Asn Phe Ile Ser Asn Val Gly Val Lys Cys Leu Gln Asn Lys Pro Gln 
    370                 375                 380                 


Met Gln Lys Lys Ser Pro Lys Pro Val Cys Gly Asn Gly Arg Leu Glu 
385                 390                 395                 400 


Gly Asn Glu Ile Cys Asp Cys Gly Xaa Glu Ala Gln Cys Gly Pro Ala 
                405                 410                 415     


Ser Cys Cys Asp Phe Arg Xaa Cys Val Leu Lys Asp Gly Ala Lys Cys 
            420                 425                 430         


Tyr Lys Gly Leu Cys Cys Lys Asp Cys Gln Ile Leu Gln Ser Gly Val 
        435                 440                 445             


Glu Cys Arg Pro Lys Ala His Pro Glu Cys Asp Ile Ala Glu Asn Cys 
    450                 455                 460                 


Asn Gly Ser Ser Pro Glu Cys Gly Pro Asp Ile Xaa Leu Ile Asn Gly 
465                 470                 475                 480 


Leu Ser Cys Lys Asn Asn Lys Phe Ile Cys Tyr Asp Gly Asp Cys His 
                485                 490                 495     


Asp Leu Asp Ala Arg Cys Glu Ser Val Phe Gly Lys Gly Ser Arg Asn 
            500                 505                 510         


Ala Pro Phe Ala Cys Tyr Glu Glu Ile Gln Ser Gln Ser Asp Arg Phe 
        515                 520                 525             


Gly Asn Cys Gly Arg Asp Arg Asn Asn Lys Tyr Val Phe Cys Gly Trp 
    530                 535                 540                 


Arg Asn Leu Ile Cys Gly Arg Leu Val Cys Xaa Tyr Pro Xaa Arg Lys 
545                 550                 555                 560 


Pro Phe His Gln Glu Asn Gly Asp Val Ile Tyr Ala Phe Val Arg Asp 
                565                 570                 575     


Ser Val Cys Ile Xaa Val Asp Tyr Lys Leu Pro Arg Xaa Val Pro Asp 
            580                 585                 590         


Pro Leu Ala Val Lys Asn Gly Ser Gln Cys Asp Ile Gly Arg Val Cys 
        595                 600                 605             


Val Asn Arg Glu Cys Val Glu Ser Arg Ile Ile Lys Ala Ser Ala His 
    610                 615                 620                 


Val Cys Ser Gln Gln Cys Ser Gly His Gly Val Cys Asp Ser Arg Asn 
625                 630                 635                 640 


Lys Cys His Cys Ser Pro Gly Tyr Lys Pro Pro Asn Cys Gln Ile Arg 
                645                 650                 655     


Ser Lys Gly Phe Ser Ile Phe Pro Glu Glu Asp Met Gly Ser Ile Met 
            660                 665                 670         


Glu Arg Ala Ser Gly Lys Xaa Glu Asn Xaa Trp Leu Leu Gly Phe Leu 
        675                 680                 685             


Ile Ala Leu Pro Ile Leu Ile Val Xaa Xaa Ala Ile Val Leu Ala Arg 
    690                 695                 700                 


Lys Gln Leu Lys Lys Trp Phe Ala Lys Glu Glu Glu Phe Pro Ser Ser 
705                 710                 715                 720 


Glu Ser Lys Ser Glu Gly Ser Xaa Gln Xaa Tyr Ala Ser Gln Ser Ser 
                725                 730                 735     


Ser Glu Gly Ser Xaa Gln Xaa Tyr Ala Ser Gln Xaa Arg Ser Glu Ser 
            740                 745                 750         


Ser Ser Gln Ala Asp Xaa Ser Lys Ser Lys Ser Glu Asp Ser Ala Glu 
        755                 760                 765             


Ala Tyr Xaa Ser Arg Ser Lys Ser Gln Asp Ser Xaa Gln Xaa Gln Ser 
    770                 775                 780                 


Ser Ser Asn 
785         


<210> 1493
<211> 184
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<400> 1493
Met Phe Arg Leu Trp Leu Leu Leu Ala Gly Leu Cys Gly Leu Leu Ala 
1               5                   10                  15      


Ser Arg Pro Gly Phe Gln Asn Ser Leu Leu Gln Ile Val Ile Pro Glu 
            20                  25                  30          


Lys Ile Gln Xaa Asn Xaa Asn Asp Ser Ser Glu Ile Glu Tyr Glu Gln 
        35                  40                  45              


Ile Ser Tyr Ile Ile Pro Ile Asp Glu Lys Leu Tyr Xaa Val His Leu 
    50                  55                  60                  


Lys Gln Arg Tyr Phe Leu Ala Asp Asn Phe Met Ile Tyr Leu Tyr Asn 
65                  70                  75                  80  


Gln Gly Ser Met Asn Xaa Tyr Ser Ser Asp Ile Gln Xaa Gln Cys Tyr 
                85                  90                  95      


Tyr Gln Gly Asn Ile Glu Gly Tyr Pro Asp Ser Met Val Xaa Leu Ser 
            100                 105                 110         


Xaa Cys Ser Gly Leu Arg Gly Ile Leu Gln Phe Glu Asn Val Ser Tyr 
        115                 120                 125             


Gly Ile Glu Pro Leu Glu Ser Ala Val Glu Phe Gln His Val Leu Tyr 
    130                 135                 140                 


Lys Leu Lys Asn Glu Asp Asn Asp Ile Ala Ile Phe Ile Asp Arg Ser 
145                 150                 155                 160 


Leu Lys Glu Gln Pro Met Asp Asp Asn Ile Phe Ile Ser Glu Lys Tyr 
                165                 170                 175     


Asp Tyr Trp Gly Ser Asp Ser Met 
            180                 


<210> 1494
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<400> 1494
Met Phe Arg Leu Trp Leu Leu Leu Ala Gly Leu Cys Gly Leu Leu Ala 
1               5                   10                  15      


Ser Arg Pro Gly Phe Gln Asn Ser Leu Leu Gln Ile Val Ile Pro Glu 
            20                  25                  30          


Lys Ile Gln Xaa Asn Xaa Asn Asp Ser Ser Glu Ile Glu Tyr Glu Gln 
        35                  40                  45              


Ile Ser Tyr Ile Ile Pro Ile Asp Glu Lys Leu Tyr Xaa Val His Leu 
    50                  55                  60                  


Lys Gln Arg Tyr Phe Leu Ala Asp Asn Phe Met Ile Tyr Leu Tyr Asn 
65                  70                  75                  80  


Gln Gly Ser Met Asn Xaa Tyr Ser Ser Asp Ile Gln Xaa Gln Cys Tyr 
                85                  90                  95      


Tyr Gln Gly Asn Ile Glu Gly Tyr Pro Asp Ser Met Val Xaa Leu Ser 
            100                 105                 110         


Xaa Cys Ser Gly Leu Arg Ser Leu Lys Glu Gln Pro Met Asp Asp Asn 
        115                 120                 125             


Ile Phe Ile Ser Glu Lys Ser Glu Pro Ala Val Pro Asp Leu Phe Pro 
    130                 135                 140                 


Leu Tyr Leu Glu Met His Ile Val Val Asp Lys 
145                 150                 155 


<210> 1495
<211> 53
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<400> 1495
Met Ile Tyr Leu Tyr Asn Gln Gly Ser Met Asn Xaa Tyr Ser Ser Asp 
1               5                   10                  15      


Ile Gln Xaa Gln Cys Tyr Tyr Gln Gly Asn Ile Glu Gly Tyr Pro Asp 
            20                  25                  30          


Ser Met Val Xaa Leu Ser Xaa Cys Ser Gly Leu Arg Gly Ile Leu Gln 
        35                  40                  45              


Phe Glu Asn Val Ser 
    50              


<210> 1496
<211> 688
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<400> 1496
Met Asn Val Arg Gly Ala Ala Pro Gly Val Arg Ala Ser Pro Arg Pro 
1               5                   10                  15      


Trp Gln Phe Pro Xaa Ser Gln Arg Leu Pro Ala Gly Ser Pro Glu Ala 
            20                  25                  30          


Ala Pro Cys Ser Ala Ser Gly Cys Cys Trp Pro Gly Ser Ala Ala Ser 
        35                  40                  45              


Trp Arg Gln Asp Pro Glu Gln Ile Ser Tyr Ile Ile Pro Ile Asp Glu 
    50                  55                  60                  


Lys Leu Tyr Xaa Val His Leu Lys Gln Arg Tyr Phe Leu Ala Asp Asn 
65                  70                  75                  80  


Phe Met Ile Tyr Leu Tyr Asn Gln Gly Ser Met Asn Xaa Tyr Ser Ser 
                85                  90                  95      


Asp Ile Gln Xaa Gln Cys Tyr Tyr Gln Gly Asn Ile Glu Gly Tyr Pro 
            100                 105                 110         


Asp Ser Met Val Xaa Leu Ser Xaa Cys Ser Gly Leu Arg Gly Ile Leu 
        115                 120                 125             


Gln Phe Glu Asn Val Ser Tyr Gly Ile Glu Pro Leu Glu Ser Ala Val 
    130                 135                 140                 


Glu Phe Gln His Val Leu Tyr Lys Leu Lys Asn Glu Asp Asn Asp Ile 
145                 150                 155                 160 


Ala Ile Phe Ile Asp Arg Ser Leu Lys Glu Gln Pro Met Asp Asp Asn 
                165                 170                 175     


Ile Phe Ile Ser Glu Lys Ser Glu Pro Ala Val Pro Asp Leu Phe Pro 
            180                 185                 190         


Leu Tyr Leu Glu Met His Ile Val Val Asp Lys Xaa Leu Tyr Asp Tyr 
        195                 200                 205             


Trp Gly Ser Asp Ser Met Ile Val Xaa Asn Lys Val Ile Glu Ile Val 
    210                 215                 220                 


Gly Leu Ala Asn Ser Met Phe Xaa Gln Phe Lys Val Xaa Ile Val Leu 
225                 230                 235                 240 


Ser Ser Leu Glu Leu Trp Ser Asp Glu Asn Lys Ile Ser Xaa Val Gly 
                245                 250                 255     


Glu Ala Asp Glu Leu Leu Gln Lys Phe Leu Glu Trp Lys Gln Ser Tyr 
            260                 265                 270         


Leu Asn Leu Arg Pro His Asp Ile Ala Tyr Leu Leu Ile Tyr Met Asp 
        275                 280                 285             


Tyr Pro Arg Tyr Leu Gly Ala Val Phe Pro Gly Xaa Met Cys Ile Xaa 
    290                 295                 300                 


Arg Tyr Ser Ala Gly Val Ala Leu Gln Cys Gly Pro Ala Ser Cys Cys 
305                 310                 315                 320 


Asp Phe Arg Xaa Cys Val Leu Lys Asp Gly Ala Lys Cys Tyr Lys Gly 
                325                 330                 335     


Leu Cys Cys Lys Asp Cys Gln Ile Leu Gln Ser Gly Val Glu Cys Arg 
            340                 345                 350         


Pro Lys Ala His Pro Glu Cys Asp Ile Ala Glu Asn Cys Asn Gly Ser 
        355                 360                 365             


Ser Pro Glu Cys Gly Pro Asp Ile Xaa Leu Ile Asn Gly Leu Ser Cys 
    370                 375                 380                 


Lys Asn Asn Lys Phe Ile Cys Tyr Asp Gly Asp Cys His Asp Leu Asp 
385                 390                 395                 400 


Ala Arg Cys Glu Ser Val Phe Gly Lys Gly Ser Arg Asn Ala Pro Phe 
                405                 410                 415     


Ala Cys Tyr Glu Glu Ile Gln Ser Gln Ser Asp Arg Phe Gly Asn Cys 
            420                 425                 430         


Gly Arg Asp Arg Asn Asn Lys Tyr Val Phe Cys Gly Trp Arg Asn Leu 
        435                 440                 445             


Ile Cys Gly Arg Leu Val Cys Xaa Tyr Pro Xaa Arg Lys Pro Phe His 
    450                 455                 460                 


Gln Glu Asn Gly Asp Val Ile Tyr Ala Phe Val Arg Asp Ser Val Cys 
465                 470                 475                 480 


Ile Xaa Val Asp Tyr Lys Leu Pro Arg Xaa Val Pro Asp Pro Leu Ala 
                485                 490                 495     


Val Lys Asn Gly Ser Gln Cys Asp Ile Gly Arg Val Cys Val Asn Arg 
            500                 505                 510         


Glu Cys Val Glu Ser Arg Ile Ile Lys Ala Ser Ala His Val Cys Ser 
        515                 520                 525             


Gln Gln Cys Ser Gly His Gly Val Cys Asp Ser Arg Asn Lys Cys His 
    530                 535                 540                 


Cys Ser Pro Gly Tyr Lys Pro Pro Asn Cys Gln Ile Arg Ser Lys Gly 
545                 550                 555                 560 


Phe Ser Ile Phe Pro Glu Glu Asp Met Gly Ser Ile Met Glu Arg Ala 
                565                 570                 575     


Ser Gly Lys Xaa Glu Asn Xaa Trp Leu Leu Gly Phe Leu Ile Ala Leu 
            580                 585                 590         


Pro Ile Leu Ile Val Xaa Xaa Ala Ile Val Leu Ala Arg Lys Gln Leu 
        595                 600                 605             


Lys Lys Trp Phe Ala Lys Glu Glu Glu Phe Pro Ser Ser Glu Ser Lys 
    610                 615                 620                 


Ser Glu Gly Ser Xaa Gln Xaa Tyr Ala Ser Gln Ser Ser Ser Glu Gly 
625                 630                 635                 640 


Ser Xaa Gln Xaa Tyr Ala Ser Gln Xaa Arg Ser Glu Ser Ser Ser Gln 
                645                 650                 655     


Ala Asp Xaa Ser Lys Ser Lys Ser Glu Asp Ser Ala Glu Ala Tyr Xaa 
            660                 665                 670         


Ser Arg Ser Lys Ser Gln Asp Ser Xaa Gln Xaa Gln Ser Ser Ser Asn 
        675                 680                 685             


<210> 1497
<211> 173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<400> 1497
Met Gln Leu Ala Leu Phe Lys Asn Met Lys Ser Trp His Phe Ile Leu 
1               5                   10                  15      


Lys Ser Gly Ser Leu Phe Pro Ser Leu Glu Cys Ser His Ile Trp Leu 
            20                  25                  30          


Asn Ser Phe Glu Lys Ile Leu Glu Xaa Gly Leu Ala Asn Met Asn Ile 
        35                  40                  45              


Tyr Leu Gly Phe Gln Asn Ser Leu Leu Gln Ile Val Ile Pro Glu Lys 
    50                  55                  60                  


Ile Gln Xaa Asn Xaa Asn Asp Ser Ser Glu Ile Glu Tyr Glu Gln Ile 
65                  70                  75                  80  


Ser Tyr Ile Ile Pro Ile Asp Glu Lys Leu Tyr Xaa Val His Leu Lys 
                85                  90                  95      


Gln Arg Tyr Phe Leu Ala Asp Asn Phe Met Ile Tyr Leu Tyr Asn Gln 
            100                 105                 110         


Gly Ser Met Asn Xaa Tyr Ser Ser Asp Ile Gln Xaa Gln Cys Tyr Tyr 
        115                 120                 125             


Gln Gly Asn Ile Glu Gly Tyr Pro Asp Ser Met Val Xaa Leu Ser Xaa 
    130                 135                 140                 


Cys Ser Gly Leu Arg Gly Ile Leu Gln Phe Glu Asn Val Ser Tyr Gly 
145                 150                 155                 160 


Ile Glu Pro Leu Glu Ser Ala Val Glu Phe Gln His Val 
                165                 170             


<210> 1498
<211> 54
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<400> 1498
Xaa Ser Lys Ser Glu Gly Ser Xaa Gln Xaa Tyr Ala Ser Gln Ser Ser 
1               5                   10                  15      


Ser Glu Gly Ser Xaa Gln Xaa Tyr Ala Ser Gln Xaa Arg Ser Glu Ser 
            20                  25                  30          


Ser Ser Gln Ala Asp Xaa Ser Lys Ser Lys Ser Gln Asp Ser Xaa Gln 
        35                  40                  45              


Xaa Gln Ser Ser Ser Asn 
    50                  


<210> 1499
<211> 245
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<400> 1499
Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Ala 
1               5                   10                  15      


Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val Val 
            20                  25                  30          


Leu Pro Trp Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro Ser 
        35                  40                  45              


His Leu Gly Gly Gln Phe Arg Pro Gln Pro Cys Pro Tyr Leu Ser Ile 
    50                  55                  60                  


Arg Gly Xaa Tyr Tyr Arg Pro Ala Arg Cys Pro Gly Leu Ile Gln Pro 
65                  70                  75                  80  


Val Ala Gln Leu Arg Leu Ser Gln Ser Ser Ala Gly Arg Ala Pro Ala 
                85                  90                  95      


Cys Xaa Trp Gly Leu Glu Met Gln Trp Ser Ser Arg Arg Leu Cys Arg 
            100                 105                 110         


His His Gln Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala 
        115                 120                 125             


Xaa Gly His Asn Phe Xaa Leu His Leu Arg Lys Asn Arg Asp Leu Leu 
    130                 135                 140                 


Gly Ser Gly Tyr Xaa Glu Xaa Tyr Xaa Ala Ala Asn Gly Ser Glu Val 
145                 150                 155                 160 


Xaa Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val 
                165                 170                 175     


Glu Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Xaa Cys Ala Gly Leu 
            180                 185                 190         


Arg Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu 
        195                 200                 205             


Asp Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His 
    210                 215                 220                 


Leu Leu Gln Xaa Ala Gly Xaa Cys Gly Val Ser Asp Asp Ser Leu Gly 
225                 230                 235                 240 


Ser Leu Leu Gly Pro 
                245 


<210> 1500
<211> 742
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<400> 1500
Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Ala 
1               5                   10                  15      


Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val Val 
            20                  25                  30          


Leu Pro Trp Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro Ser 
        35                  40                  45              


His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala Xaa 
    50                  55                  60                  


Gly His Asn Phe Xaa Leu His Leu Arg Lys Asn Arg Asp Leu Leu Gly 
65                  70                  75                  80  


Ser Gly Tyr Xaa Glu Xaa Tyr Xaa Ala Ala Asn Gly Ser Glu Val Xaa 
                85                  90                  95      


Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val Glu 
            100                 105                 110         


Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Xaa Cys Ala Gly Leu Arg 
        115                 120                 125             


Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu Asp 
    130                 135                 140                 


Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His Leu 
145                 150                 155                 160 


Leu Gln Xaa Ala Gly Xaa Cys Gly Val Ser Asp Asp Ser Leu Gly Ser 
                165                 170                 175     


Leu Leu Gly Pro Arg Xaa Ala Ala Val Phe Arg Pro Arg Pro Gly Asp 
            180                 185                 190         


Ser Leu Pro Ser Arg Glu Xaa Arg Tyr Val Glu Leu Tyr Val Val Val 
        195                 200                 205             


Asp Asn Ala Glu Phe Gln Met Leu Gly Ser Glu Ala Ala Val Arg His 
    210                 215                 220                 


Arg Val Leu Glu Val Val Asn His Val Asp Lys Leu Tyr Gln Lys Leu 
225                 230                 235                 240 


Asn Phe Arg Val Val Leu Val Gly Leu Glu Ile Trp Asn Ser Gln Asp 
                245                 250                 255     


Arg Phe His Val Ser Pro Asp Pro Ser Val Xaa Leu Glu Asn Leu Leu 
            260                 265                 270         


Xaa Trp Gln Ala Arg Gln Arg Xaa Arg Arg His Leu His Asp Asn Val 
        275                 280                 285             


Gln Leu Ile Xaa Gly Val Asp Phe Xaa Gly Xaa Xaa Val Gly Phe Ala 
    290                 295                 300                 


Arg Val Ser Ala Met Cys Ser His Ser Ser Gly Ala Val Asn Gln Asp 
305                 310                 315                 320 


His Ser Lys Asn Pro Val Gly Val Ala Cys Xaa Met Ala His Glu Met 
                325                 330                 335     


Gly His Asn Leu Gly Met Asp His Asp Glu Asn Val Gln Gly Cys Arg 
            340                 345                 350         


Cys Gln Glu Arg Phe Glu Ala Gly Arg Cys Ile Met Ala Gly Ser Ile 
        355                 360                 365             


Gly Ser Ser Phe Pro Arg Met Phe Ser Asp Cys Ser Gln Ala Tyr Leu 
    370                 375                 380                 


Glu Ser Phe Leu Glu Arg Pro Gln Ser Val Cys Leu Ala Asn Ala Pro 
385                 390                 395                 400 


Asp Leu Ser His Leu Val Gly Gly Pro Val Cys Gly Asn Leu Phe Val 
                405                 410                 415     


Glu Arg Gly Glu Gln Cys Asp Cys Gly Pro Pro Glu Asp Cys Arg Asn 
            420                 425                 430         


Arg Cys Cys Asn Ser Xaa Xaa Cys Gln Leu Ala Glu Gly Ala Gln Cys 
        435                 440                 445             


Ala His Gly Xaa Cys Cys Gln Glu Cys Lys Val Lys Pro Ala Gly Glu 
    450                 455                 460                 


Leu Cys Arg Pro Lys Lys Asp Met Cys Asp Leu Glu Glu Phe Cys Asp 
465                 470                 475                 480 


Gly Arg His Pro Glu Cys Pro Glu Asp Ala Phe Gln Glu Asn Gly Xaa 
                485                 490                 495     


Pro Cys Ser Gly Gly Tyr Cys Tyr Asn Gly Ala Cys Pro Xaa Leu Ala 
            500                 505                 510         


Gln Gln Cys Gln Ala Phe Trp Gly Pro Gly Gly Gln Ala Ala Glu Glu 
        515                 520                 525             


Ser Cys Phe Ser Tyr Asp Ile Leu Pro Gly Cys Lys Ala Ser Arg Tyr 
    530                 535                 540                 


Arg Ala Asp Met Cys Gly Val Leu Gln Cys Lys Gly Gly Gln Gln Pro 
545                 550                 555                 560 


Leu Gly Arg Ala Ile Cys Ile Val Asp Val Cys His Ala Leu Xaa Xaa 
                565                 570                 575     


Glu Asp Gly Xaa Ala Tyr Glu Pro Val Pro Glu Gly Xaa Arg Cys Gly 
            580                 585                 590         


Pro Glu Lys Val Cys Trp Lys Gly Arg Cys Gln Asp Leu His Val Tyr 
        595                 600                 605             


Arg Ser Ser Asn Cys Ser Ala Gln Cys His Asn His Gly Val Cys Asn 
    610                 615                 620                 


His Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys 
625                 630                 635                 640 


Ala Lys Leu Leu Xaa Glu Val His Ala Gly Cys Gln Pro Arg Ala Gly 
                645                 650                 655     


Gln Gly Arg Gly Ser Ser Pro Ile Gln Gly Pro Pro Arg Ala Gly Pro 
            660                 665                 670         


His His Pro Pro Gly Pro Ala Arg Pro Xaa Pro Gly Leu Leu Gly Gly 
        675                 680                 685             


Ser Glu Glu Ala Ala Pro Cys Ser Ser Gly His Cys Val Gln Pro Xaa 
    690                 695                 700                 


Leu Pro Ser Ser Cys Leu His Pro Ala Gly Xaa Lys Ala Gly His Gln 
705                 710                 715                 720 


Ala Asn Val Arg Xaa Pro Ser Ala Pro Ser Gln Xaa Arg Gly Trp Cys 
                725                 730                 735     


Gly Gln Pro Trp Ser Ser 
            740         


<210> 1501
<211> 824
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<400> 1501
Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Ala 
1               5                   10                  15      


Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val Val 
            20                  25                  30          


Leu Pro Trp Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro Ser 
        35                  40                  45              


His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala Xaa 
    50                  55                  60                  


Gly His Asn Phe Xaa Leu His Leu Arg Lys Asn Arg Asp Leu Leu Gly 
65                  70                  75                  80  


Ser Gly Tyr Xaa Glu Xaa Tyr Xaa Ala Ala Asn Gly Ser Glu Val Xaa 
                85                  90                  95      


Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val Glu 
            100                 105                 110         


Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Xaa Cys Ala Gly Leu Arg 
        115                 120                 125             


Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu Asp 
    130                 135                 140                 


Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His Leu 
145                 150                 155                 160 


Leu Gln Xaa Ala Gly Xaa Cys Gly Val Ser Asp Asp Ser Leu Gly Ser 
                165                 170                 175     


Leu Leu Gly Pro Arg Xaa Ala Ala Val Phe Arg Pro Arg Pro Gly Asp 
            180                 185                 190         


Ser Leu Pro Ser Arg Glu Xaa Arg Tyr Val Glu Leu Tyr Val Val Val 
        195                 200                 205             


Asp Asn Ala Glu Phe Gln Met Leu Gly Ser Glu Ala Ala Val Arg His 
    210                 215                 220                 


Arg Val Leu Glu Val Val Asn His Val Asp Lys Leu Tyr Gln Lys Leu 
225                 230                 235                 240 


Asn Phe Arg Val Val Leu Val Gly Leu Glu Ile Trp Asn Ser Gln Asp 
                245                 250                 255     


Arg Phe His Val Ser Pro Asp Pro Ser Val Xaa Leu Glu Asn Leu Leu 
            260                 265                 270         


Xaa Trp Gln Ala Arg Gln Arg Xaa Arg Arg His Leu His Asp Asn Val 
        275                 280                 285             


Gln Leu Ile Xaa Gly Val Asp Phe Xaa Gly Xaa Xaa Val Gly Phe Ala 
    290                 295                 300                 


Arg Val Ser Ala Met Cys Ser His Ser Ser Gly Ala Val Asn Gln Asp 
305                 310                 315                 320 


His Ser Lys Asn Pro Val Gly Val Ala Cys Xaa Met Ala His Glu Met 
                325                 330                 335     


Gly His Asn Leu Gly Met Asp His Asp Glu Asn Val Gln Gly Cys Arg 
            340                 345                 350         


Cys Gln Glu Arg Phe Glu Ala Gly Arg Cys Ile Met Ala Gly Ser Ile 
        355                 360                 365             


Gly Ser Ser Phe Pro Arg Met Phe Ser Asp Cys Ser Gln Ala Tyr Leu 
    370                 375                 380                 


Glu Ser Phe Leu Glu Arg Pro Gln Ser Val Cys Leu Ala Asn Ala Pro 
385                 390                 395                 400 


Asp Leu Ser His Leu Val Gly Gly Pro Val Cys Gly Asn Leu Phe Val 
                405                 410                 415     


Glu Arg Gly Glu Gln Cys Asp Cys Gly Pro Pro Glu Asp Cys Arg Asn 
            420                 425                 430         


Arg Cys Cys Asn Ser Xaa Xaa Cys Gln Leu Ala Glu Gly Ala Gln Cys 
        435                 440                 445             


Ala His Gly Xaa Cys Cys Gln Glu Cys Lys Val Lys Pro Ala Gly Glu 
    450                 455                 460                 


Leu Cys Arg Pro Lys Lys Asp Met Cys Asp Leu Glu Glu Phe Cys Asp 
465                 470                 475                 480 


Gly Arg His Pro Glu Cys Pro Glu Asp Ala Phe Gln Glu Asn Gly Xaa 
                485                 490                 495     


Pro Cys Ser Gly Gly Tyr Cys Tyr Asn Gly Ala Cys Pro Xaa Leu Ala 
            500                 505                 510         


Gln Gln Cys Gln Ala Phe Trp Gly Pro Gly Gly Gln Ala Ala Glu Glu 
        515                 520                 525             


Ser Cys Phe Ser Tyr Asp Ile Leu Pro Gly Cys Lys Ala Ser Arg Tyr 
    530                 535                 540                 


Arg Ala Asp Met Cys Gly Val Leu Gln Cys Lys Gly Gly Gln Gln Pro 
545                 550                 555                 560 


Leu Gly Arg Ala Ile Cys Ile Val Asp Val Cys His Ala Leu Xaa Xaa 
                565                 570                 575     


Glu Asp Gly Xaa Ala Tyr Glu Pro Val Pro Glu Gly Xaa Arg Cys Gly 
            580                 585                 590         


Pro Glu Lys Val Cys Trp Lys Gly Arg Cys Gln Asp Leu His Val Tyr 
        595                 600                 605             


Arg Ser Ser Asn Cys Ser Ala Gln Cys His Asn His Gly Val Cys Asn 
    610                 615                 620                 


His Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys 
625                 630                 635                 640 


Ala Lys Leu Leu Xaa Glu Val His Ala Ala Ser Gly Ser Leu Pro Val 
                645                 650                 655     


Phe Val Val Val Val Leu Val Leu Leu Ala Val Val Leu Val Xaa Leu 
            660                 665                 670         


Ala Gly Ile Ile Val Tyr Arg Lys Ala Arg Ser Arg Ile Leu Ser Arg 
        675                 680                 685             


Asn Val Ala Pro Lys Xaa Xaa Met Gly Arg Ser Asn Pro Leu Phe His 
    690                 695                 700                 


Gln Ala Ala Ser Arg Val Pro Ala Lys Gly Gly Ala Pro Ala Pro Ser 
705                 710                 715                 720 


Arg Gly Pro Gln Glu Leu Val Pro Xaa Xaa His Pro Gly Gln Pro Ala 
                725                 730                 735     


Arg His Pro Ala Ser Ser Val Ala Leu Lys Arg Pro Pro Pro Ala Pro 
            740                 745                 750         


Pro Val Xaa Val Ser Ser Pro Pro Phe Pro Val Pro Val Tyr Xaa Arg 
        755                 760                 765             


Gln Ala Pro Lys Gln Val Ile Lys Pro Xaa Phe Ala Pro Pro Val Pro 
    770                 775                 780                 


Pro Val Lys Pro Gly Ala Gly Ala Ala Asn Pro Gly Pro Ala Glu Gly 
785                 790                 795                 800 


Ala Val Gly Pro Lys Val Ala Leu Lys Pro Pro Ile Gln Arg Lys Gln 
                805                 810                 815     


Gly Ala Gly Ala Pro Xaa Ala Pro 
            820                 


<210> 1502
<211> 109
<212> PRT
<213> Homo sapiens

<400> 1502
Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Gly 
1               5                   10                  15      


Pro Ala Pro Arg Glu Gly Glu Leu Arg Pro Trp Gly His Arg Ala Gln 
            20                  25                  30          


Leu His Pro Pro Pro Ala Glu Glu Gln Gly Pro Ala Gly Leu Arg Leu 
        35                  40                  45              


His Arg Asp Leu Tyr Gly Cys Gln Trp Leu Arg Gly Asp Gly Ala Ala 
    50                  55                  60                  


Ser Arg Ala Gly Pro Leu Leu Leu Pro Gly Pro Arg Arg Gly Val Pro 
65                  70                  75                  80  


Gly Leu Ser Arg Gln Pro Gln His Leu Cys Arg Pro Gln Gly Phe Leu 
                85                  90                  95      


Pro Gly Gly Val Arg Pro Ala Pro Asp Arg Ala Pro Gly 
            100                 105                 


<210> 1503
<211> 733
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<400> 1503
Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Gly 
1               5                   10                  15      


Pro Ala Pro Arg Glu Gly Glu Leu Arg Pro Trp Gly His Arg Ala Gln 
            20                  25                  30          


Leu His Pro Pro Pro Ala Glu Glu Gln Gly Pro Ala Gly Leu Arg Leu 
        35                  40                  45              


His Arg Asp Leu Tyr Gly Cys Gln Trp Leu Arg Gly Asp Gly Ala Ala 
    50                  55                  60                  


Ser Arg Ala Gly Pro Leu Leu Leu Pro Gly Pro Arg Arg Gly Val Pro 
65                  70                  75                  80  


Gly Leu Ser Arg Gln Pro Gln His Leu Cys Arg Pro Gln Val Gly Ser 
                85                  90                  95      


Asp Leu His Leu Ile Glu Pro Leu Asp Glu Gly Gly Glu Gly Gly Arg 
            100                 105                 110         


His Ala Val Tyr Gln Ala Glu His Leu Leu Gln Xaa Ala Gly Xaa Cys 
        115                 120                 125             


Gly Val Ser Asp Asp Ser Leu Gly Ser Leu Leu Gly Pro Arg Xaa Ala 
    130                 135                 140                 


Ala Val Phe Arg Pro Arg Pro Gly Asp Ser Leu Pro Ser Arg Glu Xaa 
145                 150                 155                 160 


Arg Tyr Val Glu Leu Tyr Val Val Val Asp Asn Ala Glu Phe Gln Met 
                165                 170                 175     


Leu Gly Ser Glu Ala Ala Val Arg His Arg Val Leu Glu Val Val Asn 
            180                 185                 190         


His Val Asp Lys Leu Tyr Gln Lys Leu Asn Phe Arg Val Val Leu Val 
        195                 200                 205             


Gly Leu Glu Ile Trp Asn Ser Gln Asp Arg Phe His Val Ser Pro Asp 
    210                 215                 220                 


Pro Ser Val Xaa Leu Glu Asn Leu Leu Xaa Trp Gln Ala Arg Gln Arg 
225                 230                 235                 240 


Xaa Arg Arg His Leu His Asp Asn Val Gln Leu Ile Xaa Gly Val Asp 
                245                 250                 255     


Phe Xaa Gly Xaa Xaa Val Gly Phe Ala Arg Val Ser Ala Met Cys Ser 
            260                 265                 270         


His Ser Ser Gly Ala Val Asn Gln Asp His Ser Lys Asn Pro Val Gly 
        275                 280                 285             


Val Ala Cys Xaa Met Ala His Glu Met Gly His Asn Leu Gly Met Asp 
    290                 295                 300                 


His Asp Glu Asn Val Gln Gly Cys Arg Cys Gln Glu Arg Phe Glu Ala 
305                 310                 315                 320 


Gly Arg Cys Ile Met Ala Gly Ser Ile Gly Ser Ser Phe Pro Arg Met 
                325                 330                 335     


Phe Ser Asp Cys Ser Gln Ala Tyr Leu Glu Ser Phe Leu Glu Arg Pro 
            340                 345                 350         


Gln Ser Val Cys Leu Ala Asn Ala Pro Asp Leu Ser His Leu Val Gly 
        355                 360                 365             


Gly Pro Val Cys Gly Asn Leu Phe Val Glu Arg Gly Glu Gln Cys Asp 
    370                 375                 380                 


Cys Gly Pro Pro Glu Asp Cys Arg Asn Arg Cys Cys Asn Ser Xaa Xaa 
385                 390                 395                 400 


Cys Gln Leu Ala Glu Gly Ala Gln Cys Ala His Gly Xaa Cys Cys Gln 
                405                 410                 415     


Glu Cys Lys Val Lys Pro Ala Gly Glu Leu Cys Arg Pro Lys Lys Asp 
            420                 425                 430         


Met Cys Asp Leu Glu Glu Phe Cys Asp Gly Arg His Pro Glu Cys Pro 
        435                 440                 445             


Glu Asp Ala Phe Gln Glu Asn Gly Xaa Pro Cys Ser Gly Gly Tyr Cys 
    450                 455                 460                 


Tyr Asn Gly Ala Cys Pro Xaa Leu Ala Gln Gln Cys Gln Ala Phe Trp 
465                 470                 475                 480 


Gly Pro Gly Gly Gln Ala Ala Glu Glu Ser Cys Phe Ser Tyr Asp Ile 
                485                 490                 495     


Leu Pro Gly Cys Lys Ala Ser Arg Tyr Arg Ala Asp Met Cys Gly Val 
            500                 505                 510         


Leu Gln Cys Lys Gly Gly Gln Gln Pro Leu Gly Arg Ala Ile Cys Ile 
        515                 520                 525             


Val Asp Val Cys His Ala Leu Xaa Xaa Glu Asp Gly Xaa Ala Tyr Glu 
    530                 535                 540                 


Pro Val Pro Glu Gly Xaa Arg Cys Gly Pro Glu Lys Val Cys Asn His 
545                 550                 555                 560 


Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys Ala 
                565                 570                 575     


Lys Leu Leu Xaa Glu Val His Ala Ala Ser Gly Ser Leu Pro Val Phe 
            580                 585                 590         


Val Val Val Val Leu Val Leu Leu Ala Val Val Leu Val Xaa Leu Ala 
        595                 600                 605             


Gly Ile Ile Val Tyr Arg Lys Ala Arg Ser Arg Ile Leu Ser Arg Asn 
    610                 615                 620                 


Val Ala Pro Lys Xaa Xaa Met Gly Arg Ser Asn Pro Leu Phe His Gln 
625                 630                 635                 640 


Ala Ala Ser Arg Val Pro Ala Lys Gly Gly Ala Pro Ala Pro Ser Arg 
                645                 650                 655     


Gly Pro Gln Glu Leu Val Pro Xaa Xaa His Pro Gly Gln Pro Ala Arg 
            660                 665                 670         


His Pro Ala Ser Ser Val Ala Leu Lys Arg Pro Pro Pro Ala Pro Pro 
        675                 680                 685             


Val Xaa Val Ser Ser Pro Pro Phe Pro Val Pro Val Tyr Xaa Arg Gln 
    690                 695                 700                 


Ala Pro Lys Gln Gly Ala Val Gly Pro Lys Val Ala Leu Lys Pro Pro 
705                 710                 715                 720 


Ile Gln Arg Lys Gln Gly Ala Gly Ala Pro Xaa Ala Pro 
                725                 730             


<210> 1504
<211> 628
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<400> 1504
Met Gly Ser Gly Ala Arg Phe Pro Ser Gly Xaa Leu Arg Val Arg Trp 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Val Gly Pro Val Leu Gly Ala Ala Arg Pro 
            20                  25                  30          


Gly Phe Gln Gln Xaa Ser His Leu Ser Ser Tyr Glu Ile Ile Xaa Pro 
        35                  40                  45              


Trp Arg Leu Xaa Arg Glu Arg Arg Glu Ala Pro Arg Pro Tyr Ser Lys 
    50                  55                  60                  


Gln Val Ser Tyr Val Ile Gln Ala Glu Gly Lys Glu His Ile Ile His 
65                  70                  75                  80  


Leu Glu Arg Asn Lys Asp Leu Leu Pro Glu Asp Phe Val Val Tyr Xaa 
                85                  90                  95      


Tyr Asn Lys Glu Gly Xaa Leu Ile Xaa Asp His Pro Asn Ile Gln Asn 
            100                 105                 110         


His Cys His Tyr Arg Gly Tyr Val Glu Gly Val His Asn Ser Ser Ile 
        115                 120                 125             


Ala Leu Ser Asp Cys Phe Gly Leu Arg Gly Leu Leu His Leu Glu Asn 
    130                 135                 140                 


Ala Ser Tyr Gly Ile Glu Pro Leu Gln Asn Ser Ser His Phe Glu His 
145                 150                 155                 160 


Ile Ile Tyr Arg Met Asp Asp Val Tyr Lys Glu Pro Leu Lys Cys Gly 
                165                 170                 175     


Val Ser Asn Lys Asp Ile Glu Lys Glu Xaa Ala Lys Asp Glu Glu Glu 
            180                 185                 190         


Glu Pro Pro Ser Met Xaa Gln Leu Leu Arg Arg Arg Arg Ala Val Leu 
        195                 200                 205             


Pro Gln Xaa Arg Tyr Val Glu Leu Phe Ile Val Val Asp Lys Glu Arg 
    210                 215                 220                 


Tyr Asp Met Met Gly Arg Asn Gln Xaa Ala Val Arg Glu Glu Met Ile 
225                 230                 235                 240 


Leu Leu Ala Asn Tyr Leu Asp Ser Met Tyr Ile Met Leu Asn Ile Arg 
                245                 250                 255     


Ile Val Leu Val Gly Leu Glu Ile Trp Xaa Asn Gly Asn Leu Ile Asn 
            260                 265                 270         


Ile Val Gly Gly Ala Gly Asp Val Leu Gly Asn Phe Val Gln Trp Arg 
        275                 280                 285             


Glu Lys Phe Leu Ile Xaa Arg Arg Arg His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Leu Lys Lys Gly Phe Gly Gly Xaa Ala Gly Met Ala Phe Val Gly Xaa 
305                 310                 315                 320 


Val Cys Ser Arg Ser His Ala Gly Gly Ile Asn Val Phe Gly Gln Ile 
                325                 330                 335     


Xaa Val Glu Xaa Phe Ala Ser Ile Val Ala His Glu Leu Gly His Asn 
            340                 345                 350         


Leu Gly Met Asn His Asp Asp Gly Arg Asp Cys Ser Cys Gly Ala Lys 
        355                 360                 365             


Ser Cys Ile Met Asn Ser Gly Ala Ser Gly Ser Arg Asn Phe Ser Ser 
    370                 375                 380                 


Cys Ser Ala Glu Asp Phe Glu Lys Leu Xaa Leu Asn Lys Gly Gly Asn 
385                 390                 395                 400 


Cys Leu Leu Asn Ile Pro Lys Pro Asp Glu Ala Tyr Ser Ala Pro Ser 
                405                 410                 415     


Cys Gly Asn Lys Leu Val Asp Ala Gly Glu Glu Cys Asp Cys Gly Xaa 
            420                 425                 430         


Pro Lys Glu Cys Glu Leu Asp Pro Cys Cys Glu Gly Ser Xaa Cys Lys 
        435                 440                 445             


Leu Lys Ser Phe Ala Glu Cys Ala Tyr Gly Asp Cys Cys Lys Asp Cys 
    450                 455                 460                 


Arg Phe Leu Pro Gly Gly Xaa Leu Cys Arg Gly Lys Xaa Ser Glu Cys 
465                 470                 475                 480 


Asp Val Pro Glu Tyr Cys Asn Gly Ser Ser Gln Phe Cys Gln Pro Asp 
                485                 490                 495     


Val Phe Ile Gln Asn Gly Tyr Pro Cys Gln Asn Asn Lys Ala Tyr Cys 
            500                 505                 510         


Tyr Asn Gly Met Cys Gln Tyr Tyr Asp Ala Gln Cys Gln Val Ile Phe 
        515                 520                 525             


Gly Ser Lys Ala Lys Ala Ala Pro Lys Asp Cys Phe Ile Glu Val Asn 
    530                 535                 540                 


Ser Lys Gly Asp Arg Phe Gly Asn Cys Gly Phe Ser Gly Asn Glu Tyr 
545                 550                 555                 560 


Lys Lys Cys Ala Xaa Gly Asn Ala Leu Cys Gly Lys Leu Gln Cys Glu 
                565                 570                 575     


Asn Val Gln Glu Ile Pro Val Phe Gly Ile Val Pro Ala Ile Ile Gln 
            580                 585                 590         


Xaa Pro Ser Arg Gly Xaa Lys Cys Trp Gly Val Asp Phe Gln Leu Gly 
        595                 600                 605             


Ser Asp Val Pro Asp Pro Gly Met Val Asn Glu Gly Xaa Lys Cys Gly 
    610                 615                 620                 


Ala Gly Lys Lys 
625             


<210> 1505
<211> 655
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<400> 1505
Met Gly Ser Gly Ala Arg Phe Pro Ser Gly Xaa Leu Arg Val Arg Trp 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Val Gly Pro Val Leu Gly Ala Ala Arg Pro 
            20                  25                  30          


Gly Phe Gln Gln Xaa Ser His Leu Ser Ser Tyr Glu Ile Ile Xaa Pro 
        35                  40                  45              


Trp Arg Leu Xaa Arg Glu Arg Arg Glu Ala Pro Arg Pro Tyr Ser Lys 
    50                  55                  60                  


Gln Val Ser Tyr Val Ile Gln Ala Glu Gly Lys Glu His Ile Ile His 
65                  70                  75                  80  


Leu Glu Arg Asn Lys Asp Leu Leu Pro Glu Asp Phe Val Val Tyr Xaa 
                85                  90                  95      


Tyr Asn Lys Glu Gly Xaa Leu Ile Xaa Asp His Pro Asn Ile Gln Asn 
            100                 105                 110         


His Cys His Tyr Arg Gly Tyr Val Glu Gly Val His Asn Ser Ser Ile 
        115                 120                 125             


Ala Leu Ser Asp Cys Phe Gly Leu Arg Gly Leu Leu His Leu Glu Asn 
    130                 135                 140                 


Ala Ser Tyr Gly Ile Glu Pro Leu Gln Asn Ser Ser His Phe Glu His 
145                 150                 155                 160 


Ile Ile Tyr Arg Met Asp Asp Val Tyr Lys Glu Pro Leu Lys Cys Gly 
                165                 170                 175     


Val Ser Asn Lys Asp Ile Glu Lys Glu Xaa Ala Lys Asp Glu Glu Glu 
            180                 185                 190         


Glu Pro Pro Ser Met Xaa Gln Leu Leu Arg Arg Arg Arg Ala Val Leu 
        195                 200                 205             


Pro Gln Xaa Arg Tyr Val Glu Leu Phe Ile Val Val Asp Lys Glu Arg 
    210                 215                 220                 


Tyr Asp Met Met Gly Arg Asn Gln Xaa Ala Val Arg Glu Glu Met Ile 
225                 230                 235                 240 


Leu Leu Ala Asn Tyr Leu Asp Ser Met Tyr Ile Met Leu Asn Ile Arg 
                245                 250                 255     


Ile Val Leu Val Gly Leu Glu Ile Trp Xaa Asn Gly Asn Leu Ile Asn 
            260                 265                 270         


Ile Val Gly Gly Ala Gly Asp Val Leu Gly Asn Phe Val Gln Trp Arg 
        275                 280                 285             


Glu Lys Phe Leu Ile Xaa Arg Arg Arg His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Leu Lys Lys Gly Phe Gly Gly Xaa Ala Gly Met Ala Phe Val Gly Xaa 
305                 310                 315                 320 


Val Cys Ser Arg Ser His Ala Gly Gly Ile Asn Val Phe Gly Gln Ile 
                325                 330                 335     


Xaa Val Glu Xaa Phe Ala Ser Ile Val Ala His Glu Leu Gly His Asn 
            340                 345                 350         


Leu Gly Met Asn His Asp Asp Gly Arg Asp Cys Ser Cys Gly Ala Lys 
        355                 360                 365             


Ser Cys Ile Met Asn Ser Gly Ala Ser Gly Ser Arg Asn Phe Ser Ser 
    370                 375                 380                 


Cys Ser Ala Glu Asp Phe Glu Lys Leu Xaa Leu Asn Lys Gly Gly Asn 
385                 390                 395                 400 


Cys Leu Leu Asn Ile Pro Lys Pro Asp Glu Ala Tyr Ser Ala Pro Ser 
                405                 410                 415     


Cys Gly Asn Lys Leu Val Asp Ala Gly Glu Glu Cys Asp Cys Gly Xaa 
            420                 425                 430         


Pro Lys Glu Cys Glu Leu Asp Pro Cys Cys Glu Gly Ser Xaa Cys Lys 
        435                 440                 445             


Leu Lys Ser Phe Ala Glu Cys Ala Tyr Gly Asp Cys Cys Lys Asp Cys 
    450                 455                 460                 


Arg Phe Leu Pro Gly Gly Xaa Leu Cys Arg Gly Lys Xaa Ser Glu Cys 
465                 470                 475                 480 


Asp Val Pro Glu Tyr Cys Asn Gly Ser Ser Gln Phe Cys Gln Pro Asp 
                485                 490                 495     


Val Phe Ile Gln Asn Gly Tyr Pro Cys Gln Asn Asn Lys Ala Tyr Cys 
            500                 505                 510         


Tyr Asn Gly Met Cys Gln Tyr Tyr Asp Ala Gln Cys Gln Val Ile Phe 
        515                 520                 525             


Gly Ser Lys Ala Lys Ala Ala Pro Lys Asp Cys Phe Ile Glu Val Asn 
    530                 535                 540                 


Ser Lys Gly Asp Arg Phe Gly Asn Cys Gly Phe Ser Gly Asn Glu Tyr 
545                 550                 555                 560 


Lys Lys Cys Ala Xaa Gly Asn Ala Leu Cys Gly Lys Leu Gln Cys Glu 
                565                 570                 575     


Asn Val Gln Glu Ile Pro Val Phe Gly Ile Val Pro Ala Ile Ile Gln 
            580                 585                 590         


Xaa Pro Ser Arg Gly Xaa Lys Cys Trp Gly Val Asp Phe Gln Leu Gly 
        595                 600                 605             


Ser Asp Val Pro Asp Pro Gly Met Val Asn Glu Gly Xaa Lys Cys Gly 
    610                 615                 620                 


Ala Gly Lys Ile Cys Arg Asn Phe Gln Cys Val Asp Ala Ser Val Leu 
625                 630                 635                 640 


Asn Tyr Asp Cys Asp Val Gln Lys Lys Cys His Gly His Gly Lys 
                645                 650                 655 


<210> 1506
<211> 712
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<400> 1506
Met Gly Ser Gly Ala Arg Phe Pro Ser Gly Xaa Leu Arg Val Arg Trp 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Val Gly Pro Val Leu Gly Ala Ala Arg Pro 
            20                  25                  30          


Gly Phe Gln Gln Xaa Ser His Leu Ser Ser Tyr Glu Ile Ile Xaa Pro 
        35                  40                  45              


Trp Arg Leu Xaa Arg Glu Arg Arg Glu Ala Pro Arg Pro Tyr Ser Lys 
    50                  55                  60                  


Gln Val Ser Tyr Val Ile Gln Ala Glu Gly Lys Glu His Ile Ile His 
65                  70                  75                  80  


Leu Glu Arg Asn Lys Asp Leu Leu Pro Glu Asp Phe Val Val Tyr Xaa 
                85                  90                  95      


Tyr Asn Lys Glu Gly Xaa Leu Ile Xaa Asp His Pro Asn Ile Gln Asn 
            100                 105                 110         


His Cys His Tyr Arg Gly Tyr Val Glu Gly Val His Asn Ser Ser Ile 
        115                 120                 125             


Ala Leu Ser Asp Cys Phe Gly Leu Arg Gly Leu Leu His Leu Glu Asn 
    130                 135                 140                 


Ala Ser Tyr Gly Ile Glu Pro Leu Gln Asn Ser Ser His Phe Glu His 
145                 150                 155                 160 


Ile Ile Tyr Arg Met Asp Asp Val Tyr Lys Glu Pro Leu Lys Cys Gly 
                165                 170                 175     


Val Ser Asn Lys Asp Ile Glu Lys Glu Xaa Ala Lys Asp Glu Glu Glu 
            180                 185                 190         


Glu Pro Pro Ser Met Xaa Gln Leu Leu Arg Arg Arg Arg Ala Val Leu 
        195                 200                 205             


Pro Gln Xaa Arg Tyr Val Glu Leu Phe Ile Val Val Asp Lys Glu Arg 
    210                 215                 220                 


Tyr Asp Met Met Gly Arg Asn Gln Xaa Ala Val Arg Glu Glu Met Ile 
225                 230                 235                 240 


Leu Leu Ala Asn Tyr Leu Asp Ser Met Tyr Ile Met Leu Asn Ile Arg 
                245                 250                 255     


Ile Val Leu Val Gly Leu Glu Ile Trp Xaa Asn Gly Asn Leu Ile Asn 
            260                 265                 270         


Ile Val Gly Gly Ala Gly Asp Val Leu Gly Asn Phe Val Gln Trp Arg 
        275                 280                 285             


Glu Lys Phe Leu Ile Xaa Arg Arg Arg His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Leu Lys Lys Gly Phe Gly Gly Xaa Ala Gly Met Ala Phe Val Gly Xaa 
305                 310                 315                 320 


Val Cys Ser Arg Ser His Ala Gly Gly Ile Asn Val Phe Gly Gln Ile 
                325                 330                 335     


Xaa Val Glu Xaa Phe Ala Ser Ile Val Ala His Glu Leu Gly His Asn 
            340                 345                 350         


Leu Gly Met Asn His Asp Asp Gly Arg Asp Cys Ser Cys Gly Ala Lys 
        355                 360                 365             


Ser Cys Ile Met Asn Ser Gly Ala Ser Gly Ser Arg Asn Phe Ser Ser 
    370                 375                 380                 


Cys Ser Ala Glu Asp Phe Glu Lys Leu Xaa Leu Asn Lys Gly Gly Asn 
385                 390                 395                 400 


Cys Leu Leu Asn Ile Pro Lys Pro Asp Glu Ala Tyr Ser Ala Pro Ser 
                405                 410                 415     


Cys Gly Asn Lys Leu Val Asp Ala Gly Glu Glu Cys Asp Cys Gly Xaa 
            420                 425                 430         


Pro Lys Glu Cys Glu Leu Asp Pro Cys Cys Glu Gly Ser Xaa Cys Lys 
        435                 440                 445             


Leu Lys Ser Phe Ala Glu Cys Ala Tyr Gly Asp Cys Cys Lys Asp Cys 
    450                 455                 460                 


Arg Phe Leu Pro Gly Gly Xaa Leu Cys Arg Gly Lys Xaa Ser Glu Cys 
465                 470                 475                 480 


Asp Val Pro Glu Tyr Cys Asn Gly Ser Ser Gln Phe Cys Gln Pro Asp 
                485                 490                 495     


Val Phe Ile Gln Asn Gly Tyr Pro Cys Gln Asn Asn Lys Ala Tyr Cys 
            500                 505                 510         


Tyr Asn Gly Met Cys Gln Tyr Tyr Asp Ala Gln Cys Gln Val Ile Phe 
        515                 520                 525             


Gly Ser Lys Ala Lys Ala Ala Pro Lys Asp Cys Phe Ile Glu Val Asn 
    530                 535                 540                 


Ser Lys Gly Asp Arg Phe Gly Asn Cys Gly Phe Ser Gly Asn Glu Tyr 
545                 550                 555                 560 


Lys Lys Cys Ala Xaa Gly Asn Ala Leu Cys Gly Lys Leu Gln Cys Glu 
                565                 570                 575     


Asn Val Gln Glu Ile Pro Val Phe Gly Ile Val Pro Ala Ile Ile Gln 
            580                 585                 590         


Xaa Pro Ser Arg Gly Xaa Lys Cys Trp Gly Val Asp Phe Gln Leu Gly 
        595                 600                 605             


Ser Asp Val Pro Asp Pro Gly Met Val Asn Glu Gly Xaa Lys Cys Gly 
    610                 615                 620                 


Ala Gly Lys Ile Cys Arg Asn Phe Gln Cys Val Asp Ala Ser Val Leu 
625                 630                 635                 640 


Asn Tyr Asp Cys Asp Val Gln Lys Lys Cys His Gly His Gly Val Cys 
                645                 650                 655     


Asn Ser Asn Lys Asn Cys His Cys Glu Asn Gly Trp Ala Pro Pro Asn 
            660                 665                 670         


Cys Glu Xaa Lys Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Xaa Tyr 
        675                 680                 685             


Asn Gly Gln Met Ala Lys Ile Lys Gln Xaa Leu Leu Asp Ser Arg Gly 
    690                 695                 700                 


Val Phe Leu Asp Met Phe Leu Gln 
705                 710         


<210> 1507
<211> 819
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<400> 1507
Met Gly Ser Gly Ala Arg Phe Pro Ser Gly Xaa Leu Arg Val Arg Trp 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Val Gly Pro Val Leu Gly Ala Ala Arg Pro 
            20                  25                  30          


Gly Phe Gln Gln Xaa Ser His Leu Ser Ser Tyr Glu Ile Ile Xaa Pro 
        35                  40                  45              


Trp Arg Leu Xaa Arg Glu Arg Arg Glu Ala Pro Arg Pro Tyr Ser Lys 
    50                  55                  60                  


Gln Val Ser Tyr Val Ile Gln Ala Glu Gly Lys Glu His Ile Ile His 
65                  70                  75                  80  


Leu Glu Arg Asn Lys Asp Leu Leu Pro Glu Asp Phe Val Val Tyr Xaa 
                85                  90                  95      


Tyr Asn Lys Glu Gly Xaa Leu Ile Xaa Asp His Pro Asn Ile Gln Asn 
            100                 105                 110         


His Cys His Tyr Arg Gly Tyr Val Glu Gly Val His Asn Ser Ser Ile 
        115                 120                 125             


Ala Leu Ser Asp Cys Phe Gly Leu Arg Gly Leu Leu His Leu Glu Asn 
    130                 135                 140                 


Ala Ser Tyr Gly Ile Glu Pro Leu Gln Asn Ser Ser His Phe Glu His 
145                 150                 155                 160 


Ile Ile Tyr Arg Met Asp Asp Val Tyr Lys Glu Pro Leu Lys Cys Gly 
                165                 170                 175     


Val Ser Asn Lys Asp Ile Glu Lys Glu Xaa Ala Lys Asp Glu Glu Glu 
            180                 185                 190         


Glu Pro Pro Ser Met Xaa Gln Leu Leu Arg Arg Arg Arg Ala Val Leu 
        195                 200                 205             


Pro Gln Xaa Arg Tyr Val Glu Leu Phe Ile Val Val Asp Lys Glu Arg 
    210                 215                 220                 


Tyr Asp Met Met Gly Arg Asn Gln Xaa Ala Val Arg Glu Glu Met Ile 
225                 230                 235                 240 


Leu Leu Ala Asn Tyr Leu Asp Ser Met Tyr Ile Met Leu Asn Ile Arg 
                245                 250                 255     


Ile Val Leu Val Gly Leu Glu Ile Trp Xaa Asn Gly Asn Leu Ile Asn 
            260                 265                 270         


Ile Val Gly Gly Ala Gly Asp Val Leu Gly Asn Phe Val Gln Trp Arg 
        275                 280                 285             


Glu Lys Phe Leu Ile Xaa Arg Arg Arg His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Leu Lys Lys Gly Phe Gly Gly Xaa Ala Gly Met Ala Phe Val Gly Xaa 
305                 310                 315                 320 


Val Cys Ser Arg Ser His Ala Gly Gly Ile Asn Val Phe Gly Gln Ile 
                325                 330                 335     


Xaa Val Glu Xaa Phe Ala Ser Ile Val Ala His Glu Leu Gly His Asn 
            340                 345                 350         


Leu Gly Met Asn His Asp Asp Gly Arg Asp Cys Ser Cys Gly Ala Lys 
        355                 360                 365             


Ser Cys Ile Met Asn Ser Gly Ala Ser Gly Ser Arg Asn Phe Ser Ser 
    370                 375                 380                 


Cys Ser Ala Glu Asp Phe Glu Lys Leu Xaa Leu Asn Lys Gly Gly Asn 
385                 390                 395                 400 


Cys Leu Leu Asn Ile Pro Lys Pro Asp Glu Ala Tyr Ser Ala Pro Ser 
                405                 410                 415     


Cys Gly Asn Lys Leu Val Asp Ala Gly Glu Glu Cys Asp Cys Gly Xaa 
            420                 425                 430         


Pro Lys Glu Cys Glu Leu Asp Pro Cys Cys Glu Gly Ser Xaa Cys Lys 
        435                 440                 445             


Leu Lys Ser Phe Ala Glu Cys Ala Tyr Gly Asp Cys Cys Lys Asp Cys 
    450                 455                 460                 


Arg Phe Leu Pro Gly Gly Xaa Leu Cys Arg Gly Lys Xaa Ser Glu Cys 
465                 470                 475                 480 


Asp Val Pro Glu Tyr Cys Asn Gly Ser Ser Gln Phe Cys Gln Pro Asp 
                485                 490                 495     


Val Phe Ile Gln Asn Gly Tyr Pro Cys Gln Asn Asn Lys Ala Tyr Cys 
            500                 505                 510         


Tyr Asn Gly Met Cys Gln Tyr Tyr Asp Ala Gln Cys Gln Val Ile Phe 
        515                 520                 525             


Gly Ser Lys Ala Lys Ala Ala Pro Lys Asp Cys Phe Ile Glu Val Asn 
    530                 535                 540                 


Ser Lys Gly Asp Arg Phe Gly Asn Cys Gly Phe Ser Gly Asn Glu Tyr 
545                 550                 555                 560 


Lys Lys Cys Ala Xaa Gly Asn Ala Leu Cys Gly Lys Leu Gln Cys Glu 
                565                 570                 575     


Asn Val Gln Glu Ile Pro Val Phe Gly Ile Val Pro Ala Ile Ile Gln 
            580                 585                 590         


Xaa Pro Ser Arg Gly Xaa Lys Cys Trp Gly Val Asp Phe Gln Leu Gly 
        595                 600                 605             


Ser Asp Val Pro Asp Pro Gly Met Val Asn Glu Gly Xaa Lys Cys Gly 
    610                 615                 620                 


Ala Gly Lys Ile Cys Arg Asn Phe Gln Cys Val Asp Ala Ser Val Leu 
625                 630                 635                 640 


Asn Tyr Asp Cys Asp Val Gln Lys Lys Cys His Gly His Gly Val Cys 
                645                 650                 655     


Asn Ser Asn Lys Asn Cys His Cys Glu Asn Gly Trp Ala Pro Pro Asn 
            660                 665                 670         


Cys Glu Xaa Lys Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Xaa Tyr 
        675                 680                 685             


Asn Glu Met Asn Xaa Ala Leu Arg Asp Gly Leu Leu Val Phe Phe Phe 
    690                 695                 700                 


Leu Ile Val Pro Leu Ile Val Cys Ala Ile Phe Ile Phe Ile Lys Arg 
705                 710                 715                 720 


Asp Gln Leu Trp Arg Ser Tyr Phe Arg Lys Lys Arg Ser Gln Xaa Tyr 
                725                 730                 735     


Glu Ser Asp Gly Lys Asn Gln Ala Asn Pro Ser Arg Gln Pro Gly Ser 
            740                 745                 750         


Val Pro Arg His Val Ser Pro Val Xaa Pro Pro Arg Glu Val Pro Ile 
        755                 760                 765             


Tyr Ala Asn Arg Phe Ala Val Pro Xaa Tyr Ala Ala Lys Gln Pro Gln 
    770                 775                 780                 


Gln Phe Pro Ser Arg Pro Pro Pro Pro Gln Pro Lys Val Ser Ser Gln 
785                 790                 795                 800 


Gly Asn Leu Ile Pro Ala Arg Pro Ala Pro Ala Pro Pro Leu Tyr Ser 
                805                 810                 815     


Ser Leu Xaa 
            


<210> 1508
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<400> 1508
Met Gly Ser Gly Ala Arg Phe Pro Ser Gly Xaa Leu Arg Val Arg Trp 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Val Gly Pro Val Leu Gly Ala Ala Arg Pro 
            20                  25                  30          


Gly Phe Gln Gln Xaa Ser His Leu Ser Ser Tyr Glu Ile Ile Xaa Pro 
        35                  40                  45              


Trp Arg Leu Xaa Arg Glu Arg Arg Glu Ala Pro Arg Pro Tyr Ser Lys 
    50                  55                  60                  


Gln Val Ser Tyr Val Ile Gln Ala Glu Gly Lys Glu His Ile Ile His 
65                  70                  75                  80  


Leu Glu Arg Asn Lys Asp Leu Leu Pro Glu Asp Phe Val Val Tyr Xaa 
                85                  90                  95      


Tyr Asn Lys Glu Gly Xaa Leu Ile Xaa Asp His Pro Asn Ile Gln Arg 
            100                 105                 110         


Cys Gly Pro Leu Cys Ile Arg Glu Gln Ser Xaa Pro Gly Asp Arg Ala 
        115                 120                 125             


Gly Gln Asn Xaa Gln Asn Asn Trp Gln Met Ser Asn Leu Ala Phe Cys 
    130                 135                 140                 


Val Tyr Tyr 
145         


<210> 1509
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<400> 1509
Met Gly Ser Gly Ala Arg Phe Pro Ser Gly Xaa Leu Arg Val Arg Trp 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Val Gly Pro Val Leu Gly Ala Ala Arg Pro 
            20                  25                  30          


Gly Phe Gln Gln Xaa Ser His Leu Ser Ser Tyr Glu Ile Ile Xaa Pro 
        35                  40                  45              


Trp Arg Leu Xaa Arg Glu Arg Arg Glu Ala Pro Arg Pro Tyr Ser Lys 
    50                  55                  60                  


Gln Val Ser Tyr Val Ile Gln Ala Glu Gly Lys Glu His Ile Ile His 
65                  70                  75                  80  


Leu Glu Arg Asn Lys Asp Leu Leu Pro Glu Asp Phe Val Val Tyr Xaa 
                85                  90                  95      


Tyr Asn Lys Glu Gly Xaa Leu Ile Xaa Asp His Pro Asn Ile Gln Val 
            100                 105                 110         


Met Tyr Phe Ser Leu Asp Pro Ile Ala Asn Phe Lys Xaa Ile Ile Ile 
        115                 120                 125             


<210> 1510
<211> 171
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(137)
<223> Selenocysteine

<400> 1510
Met Leu Val Ala Asp Gln Ser Met Ala Glu Phe His Gly Ser Gly Leu 
1               5                   10                  15      


Lys His Tyr Leu Leu Xaa Leu Phe Ser Val Ala Ala Arg Leu Tyr Lys 
            20                  25                  30          


His Pro Ser Ile Arg Asn Ser Val Ser Leu Val Val Val Lys Ile Leu 
        35                  40                  45              


Val Ile His Asp Glu Gln Lys Gly Pro Glu Val Xaa Ser Asn Ala Ala 
    50                  55                  60                  


Leu Xaa Leu Arg Asn Phe Cys Asn Trp Gln Lys Gln His Asn Pro Pro 
65                  70                  75                  80  


Ser Asp Arg Asp Ala Glu His Tyr Asp Xaa Ala Ile Leu Phe Xaa Arg 
                85                  90                  95      


Gln Asp Leu Cys Gly Ser Gln Xaa Cys Asp Xaa Leu Gly Met Ala Asp 
            100                 105                 110         


Val Gly Xaa Val Cys Asp Pro Ser Arg Ser Cys Ser Val Ile Glu Asp 
        115                 120                 125             


Asp Gly Leu Gln Ala Ala Phe Xaa Xaa Ala His Glu Leu Gly His Val 
    130                 135                 140                 


Phe Asn Met Pro His Asp Asp Ala Lys Gln Cys Ala Ser Leu Asn Gly 
145                 150                 155                 160 


Val Asn Gln Asp Ser His Met Met Ala Ser Met 
                165                 170     


<210> 1511
<211> 967
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<400> 1511
Met Gln Arg Ala Val Pro Glu Gly Phe Gly Arg Arg Lys Leu Gly Ser 
1               5                   10                  15      


Asp Met Gly Asn Ala Glu Arg Ala Pro Gly Ser Arg Ser Phe Gly Pro 
            20                  25                  30          


Val Pro Xaa Leu Leu Leu Leu Ala Ala Ala Leu Leu Ala Val Ser Asp 
        35                  40                  45              


Ala Leu Gly Arg Pro Ser Glu Glu Asp Glu Glu Leu Val Val Pro Glu 
    50                  55                  60                  


Leu Glu Arg Ala Pro Gly His Gly Xaa Xaa Arg Leu Arg Leu His Ala 
65                  70                  75                  80  


Phe Asp Gln Gln Leu Asp Leu Glu Leu Arg Pro Asp Ser Ser Phe Leu 
                85                  90                  95      


Ala Pro Gly Phe Xaa Leu Gln Asn Val Gly Arg Lys Ser Gly Ser Glu 
            100                 105                 110         


Xaa Pro Leu Pro Glu Xaa Asp Leu Ala His Cys Phe Tyr Ser Gly Xaa 
        115                 120                 125             


Val Asn Gly Asp Pro Ser Ser Ala Ala Ala Leu Ser Leu Cys Glu Gly 
    130                 135                 140                 


Val Arg Gly Ala Phe Tyr Leu Leu Gly Glu Ala Tyr Phe Ile Gln Pro 
145                 150                 155                 160 


Leu Pro Ala Ala Ser Glu Arg Leu Ala Xaa Ala Ala Pro Gly Glu Lys 
                165                 170                 175     


Pro Pro Ala Pro Leu Gln Phe His Leu Leu Arg Arg Asn Arg Gln Gly 
            180                 185                 190         


Asp Val Gly Gly Xaa Cys Gly Val Val Asp Asp Glu Pro Arg Pro Xaa 
        195                 200                 205             


Gly Lys Ala Glu Xaa Glu Asp Glu Asp Glu Gly Xaa Glu Gly Glu Asp 
    210                 215                 220                 


Glu Gly Ala Gln Trp Ser Pro Gln Asp Pro Ala Leu Gln Gly Val Gly 
225                 230                 235                 240 


Gln Pro Xaa Gly Xaa Gly Ser Ile Arg Lys Lys Arg Phe Val Ser Ser 
                245                 250                 255     


His Arg Tyr Val Glu Xaa Met Leu Val Ala Asp Gln Ser Met Ala Glu 
            260                 265                 270         


Phe His Gly Ser Gly Leu Lys His Tyr Leu Leu Xaa Leu Phe Ser Val 
        275                 280                 285             


Ala Ala Arg Leu Tyr Lys His Pro Ser Ile Arg Asn Ser Val Ser Leu 
    290                 295                 300                 


Val Val Val Lys Ile Leu Val Ile His Asp Glu Gln Lys Gly Pro Glu 
305                 310                 315                 320 


Val Xaa Ser Asn Ala Ala Leu Xaa Leu Arg Asn Phe Cys Asn Trp Gln 
                325                 330                 335     


Lys Gln His Asn Pro Pro Ser Asp Arg Asp Ala Glu His Tyr Asp Xaa 
            340                 345                 350         


Ala Ile Leu Phe Xaa Arg Gln Asp Leu Cys Gly Ser Gln Xaa Cys Asp 
        355                 360                 365             


Xaa Leu Gly Met Ala Asp Val Gly Xaa Val Cys Asp Pro Ser Arg Ser 
    370                 375                 380                 


Cys Ser Val Ile Glu Asp Asp Gly Leu Gln Ala Ala Phe Xaa Xaa Ala 
385                 390                 395                 400 


His Glu Leu Gly His Val Phe Asn Met Pro His Asp Asp Ala Lys Gln 
                405                 410                 415     


Cys Ala Ser Leu Asn Gly Val Asn Gln Asp Ser His Met Met Ala Ser 
            420                 425                 430         


Met Leu Ser Asn Leu Asp His Ser Gln Pro Trp Ser Pro Cys Ser Ala 
        435                 440                 445             


Tyr Met Ile Xaa Ser Phe Leu Asp Asn Gly His Gly Glu Cys Leu Met 
    450                 455                 460                 


Asp Lys Pro Gln Asn Pro Ile Gln Leu Pro Gly Asp Leu Pro Gly Xaa 
465                 470                 475                 480 


Ser Tyr Asp Ala Asn Arg Gln Cys Gln Phe Xaa Phe Gly Glu Asp Ser 
                485                 490                 495     


Lys His Cys Pro Asp Ala Ala Ser Xaa Cys Ser Xaa Leu Trp Cys Xaa 
            500                 505                 510         


Gly Xaa Ser Gly Gly Val Leu Val Cys Gln Xaa Lys His Phe Pro Trp 
        515                 520                 525             


Ala Asp Gly Xaa Ser Cys Gly Glu Gly Lys Trp Cys Ile Asn Gly Lys 
    530                 535                 540                 


Cys Val Asn Lys Xaa Asp Arg Lys His Phe Asp Xaa Pro Phe His Gly 
545                 550                 555                 560 


Ser Trp Gly Met Trp Gly Pro Trp Gly Asp Cys Ser Arg Xaa Cys Gly 
                565                 570                 575     


Gly Gly Val Gln Tyr Xaa Met Arg Glu Cys Asp Asn Pro Val Pro Lys 
            580                 585                 590         


Asn Gly Gly Lys Tyr Cys Glu Gly Lys Arg Val Arg Tyr Arg Ser Cys 
        595                 600                 605             


Asn Leu Glu Asp Cys Pro Asp Asn Asn Gly Lys Xaa Phe Arg Glu Glu 
    610                 615                 620                 


Gln Cys Glu Ala His Asn Glu Phe Ser Lys Ala Ser Phe Gly Ser Gly 
625                 630                 635                 640 


Pro Ala Val Glu Trp Ile Pro Lys Tyr Ala Gly Val Ser Pro Lys Asp 
                645                 650                 655     


Arg Cys Lys Leu Ile Cys Gln Ala Lys Gly Ile Gly Tyr Phe Phe Val 
            660                 665                 670         


Leu Gln Pro Lys Val Val Asp Gly Xaa Pro Cys Ser Pro Asp Ser Xaa 
        675                 680                 685             


Ser Val Cys Val Gln Gly Gln Cys Val Lys Ala Gly Cys Asp Arg Ile 
    690                 695                 700                 


Ile Asp Ser Lys Lys Lys Phe Asp Lys Cys Gly Val Cys Gly Gly Asn 
705                 710                 715                 720 


Gly Ser Xaa Cys Lys Lys Ile Ser Gly Ser Val Xaa Ser Ala Lys Pro 
                725                 730                 735     


Gly Tyr His Asp Ile Ile Xaa Ile Pro Xaa Gly Ala Xaa Asn Ile Glu 
            740                 745                 750         


Val Lys Gln Arg Asn Gln Arg Gly Ser Arg Asn Asn Gly Ser Phe Leu 
        755                 760                 765             


Ala Ile Lys Ala Ala Asp Gly Xaa Tyr Ile Leu Asn Gly Asp Tyr Xaa 
    770                 775                 780                 


Leu Ser Xaa Leu Glu Gln Asp Ile Met Tyr Lys Gly Val Val Leu Arg 
785                 790                 795                 800 


Tyr Ser Gly Ser Ser Ala Ala Leu Glu Arg Ile Arg Ser Phe Ser Pro 
                805                 810                 815     


Leu Lys Glu Pro Leu Xaa Ile Gln Val Leu Xaa Val Gly Asn Ala Leu 
            820                 825                 830         


Arg Pro Lys Ile Lys Tyr Xaa Tyr Phe Val Lys Lys Lys Lys Glu Ser 
        835                 840                 845             


Phe Asn Ala Ile Pro Xaa Phe Ser Ala Trp Val Ile Glu Glu Trp Gly 
    850                 855                 860                 


Glu Cys Ser Lys Ser Cys Glu Leu Gly Trp Gln Arg Arg Leu Val Glu 
865                 870                 875                 880 


Cys Arg Asp Ile Asn Gly Gln Pro Ala Ser Glu Cys Ala Lys Glu Val 
                885                 890                 895     


Lys Pro Ala Ser Xaa Arg Pro Cys Ala Asp His Pro Cys Pro Gln Trp 
            900                 905                 910         


Gln Leu Gly Glu Trp Ser Ser Cys Ser Lys Xaa Cys Gly Lys Gly Tyr 
        915                 920                 925             


Lys Lys Arg Ser Leu Lys Cys Leu Ser His Asp Gly Gly Val Leu Ser 
    930                 935                 940                 


His Glu Ser Cys Asp Pro Leu Lys Lys Pro Lys His Phe Ile Asp Phe 
945                 950                 955                 960 


Cys Xaa Met Ala Glu Cys Ser 
                965         


<210> 1512
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 1512
Met Val Xaa Trp Glu Gly Xaa Gly Ser Ile Arg Lys Lys Arg Phe Val 
1               5                   10                  15      


Ser Ser His Arg Tyr Val Glu Xaa Met Leu Val Ala Asp Gln Ser Met 
            20                  25                  30          


Ala Glu Phe His Gly Ser Gly Leu Lys His Tyr Leu Leu Xaa Leu Phe 
        35                  40                  45              


Ser Val Ala Ala Arg Leu Tyr Lys His Pro Ser Ile Arg Asn Ser Val 
    50                  55                  60                  


Ser Leu Val Val Val Lys Ile Leu Val Ile His Asp Glu Gln Lys Gly 
65                  70                  75                  80  


Pro Glu Val Xaa Ser Asn Ala Ala Leu Xaa Leu Arg Asn Phe Cys Asn 
                85                  90                  95      


Trp Gln Lys Gln His Asn Pro Pro Ser Asp Arg Asp Ala Glu His Tyr 
            100                 105                 110         


Asp Xaa Ala Ile Leu Phe Xaa Arg Gln Asp Leu Cys Gly Ser Gln Xaa 
        115                 120                 125             


<210> 1513
<211> 200
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(181)
<223> Selenocysteine

<400> 1513
Xaa Cys Arg Ser Phe Leu Leu Arg Pro Ser Leu Cys Ala Val Leu Ile 
1               5                   10                  15      


Leu Gln Phe Phe Leu Phe His His Phe Gly Xaa Gly Ser Ile Arg Lys 
            20                  25                  30          


Lys Arg Phe Val Ser Ser His Arg Tyr Val Glu Xaa Met Leu Val Ala 
        35                  40                  45              


Asp Gln Ser Met Ala Glu Phe His Gly Ser Gly Leu Lys His Tyr Leu 
    50                  55                  60                  


Leu Xaa Leu Phe Ser Val Ala Ala Arg Leu Tyr Lys His Pro Ser Ile 
65                  70                  75                  80  


Arg Asn Ser Val Ser Leu Val Val Val Lys Ile Leu Val Ile His Asp 
                85                  90                  95      


Glu Gln Lys Gly Pro Glu Val Xaa Ser Asn Ala Ala Leu Xaa Leu Arg 
            100                 105                 110         


Asn Phe Cys Asn Trp Gln Lys Gln His Asn Pro Pro Ser Asp Arg Asp 
        115                 120                 125             


Ala Glu His Tyr Asp Xaa Ala Ile Leu Phe Xaa Arg Gln Asp Leu Cys 
    130                 135                 140                 


Gly Ser Gln Xaa Cys Asp Xaa Leu Gly Met Ala Asp Val Gly Xaa Val 
145                 150                 155                 160 


Cys Asp Pro Ser Arg Ser Cys Ser Val Ile Glu Asp Asp Gly Leu Gln 
                165                 170                 175     


Ala Ala Phe Xaa Xaa Ala His Glu Leu Gly His Val Phe Asn Met Pro 
            180                 185                 190         


His Asp Asp Ala Lys Gln Cys Ala 
        195                 200 


<210> 1514
<211> 1509
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1093)..(1093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1107)..(1107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1193)..(1193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1206)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1224)..(1224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1377)..(1377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1379)..(1379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1392)..(1392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1400)..(1400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1410)..(1410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1421)..(1421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1466)..(1466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1477)..(1477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1489)..(1489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1492)..(1492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1494)..(1494)
<223> Selenocysteine

<400> 1514
Met Pro Cys Ala Gln Arg Ser Trp Leu Ala Asn Leu Ser Val Val Ala 
1               5                   10                  15      


Gln Leu Leu Asn Phe Gly Ala Leu Cys Tyr Gly Arg Gln Pro Gln Pro 
            20                  25                  30          


Gly Pro Val Arg Phe Pro Asp Arg Arg Gln Glu His Phe Ile Lys Gly 
        35                  40                  45              


Leu Pro Glu Tyr His Val Val Gly Pro Val Arg Val Asp Ala Ser Gly 
    50                  55                  60                  


His Phe Leu Ser Tyr Gly Leu His Tyr Pro Ile Xaa Ser Ser Arg Arg 
65                  70                  75                  80  


Lys Arg Asp Leu Asp Gly Ser Glu Asp Trp Val Tyr Tyr Arg Ile Ser 
                85                  90                  95      


His Glu Glu Lys Asp Leu Phe Phe Asn Leu Xaa Val Asn Gln Gly Phe 
            100                 105                 110         


Leu Ser Asn Ser Tyr Ile Met Glu Lys Arg Tyr Gly Asn Leu Ser His 
        115                 120                 125             


Val Lys Met Met Ala Ser Ser Ala Pro Leu Cys His Leu Ser Gly Xaa 
    130                 135                 140                 


Val Leu Gln Gln Gly Xaa Arg Val Gly Xaa Ala Ala Leu Ser Ala Cys 
145                 150                 155                 160 


His Gly Leu Xaa Gly Phe Phe Gln Leu Pro His Gly Asp Phe Phe Ile 
                165                 170                 175     


Glu Pro Val Lys Lys His Pro Leu Val Glu Gly Gly Tyr His Pro His 
            180                 185                 190         


Ile Val Tyr Arg Arg Gln Lys Val Pro Glu Xaa Lys Glu Pro Xaa Cys 
        195                 200                 205             


Gly Leu Lys Asp Ser Val Asn Ile Ser Gln Lys Gln Glu Leu Trp Arg 
    210                 215                 220                 


Glu Lys Trp Glu Arg His Asn Leu Pro Ser Arg Ser Leu Ser Arg Arg 
225                 230                 235                 240 


Ser Ile Ser Lys Glu Arg Trp Val Glu Xaa Leu Val Val Ala Asp Xaa 
                245                 250                 255     


Lys Met Ile Glu Tyr His Gly Ser Glu Asn Val Glu Ser Tyr Ile Leu 
            260                 265                 270         


Xaa Ile Met Asn Met Val Xaa Gly Leu Phe His Asn Pro Ser Ile Gly 
        275                 280                 285             


Asn Ala Ile His Ile Val Val Val Arg Leu Ile Leu Leu Glu Glu Glu 
    290                 295                 300                 


Glu Gln Gly Leu Lys Ile Val His His Ala Glu Lys Xaa Leu Ser Ser 
305                 310                 315                 320 


Phe Cys Lys Trp Gln Lys Ser Ile Asn Pro Lys Ser Asp Leu Asn Pro 
                325                 330                 335     


Val His His Asp Val Ala Val Leu Leu Xaa Arg Lys Asp Ile Cys Ala 
            340                 345                 350         


Gly Phe Asn Arg Pro Cys Glu Xaa Leu Gly Leu Ser His Leu Ser Gly 
        355                 360                 365             


Met Cys Gln Pro His Arg Ser Cys Asn Ile Asn Glu Asp Ser Gly Leu 
    370                 375                 380                 


Pro Leu Ala Phe Xaa Ile Ala His Glu Leu Gly His Ser Phe Gly Ile 
385                 390                 395                 400 


Gln His Asp Gly Lys Glu Asn Asp Cys Glu Pro Val Gly Arg His Pro 
                405                 410                 415     


Tyr Ile Met Ser Arg Gln Leu Gln Tyr Asp Pro Xaa Pro Leu Xaa Trp 
            420                 425                 430         


Ser Lys Cys Ser Glu Glu Tyr Ile Xaa Arg Phe Leu Asp Arg Gly Trp 
        435                 440                 445             


Gly Phe Cys Leu Asp Asp Ile Pro Lys Lys Lys Gly Leu Lys Ser Lys 
    450                 455                 460                 


Val Ile Ala Pro Gly Val Ile Tyr Asp Val His His Gln Cys Gln Leu 
465                 470                 475                 480 


Gln Tyr Gly Pro Asn Ala Xaa Phe Cys Gln Glu Val Glu Asn Val Cys 
                485                 490                 495     


Gln Xaa Leu Trp Cys Ser Val Lys Gly Phe Cys Arg Ser Lys Leu Asp 
            500                 505                 510         


Ala Ala Ala Asp Gly Xaa Gln Cys Gly Glu Lys Lys Trp Cys Met Ala 
        515                 520                 525             


Gly Lys Cys Ile Xaa Val Gly Lys Lys Pro Glu Ser Ile Pro Gly Gly 
    530                 535                 540                 


Trp Gly Arg Trp Ser Pro Trp Ser His Cys Ser Arg Xaa Cys Gly Ala 
545                 550                 555                 560 


Gly Val Gln Ser Ala Glu Arg Leu Cys Asn Asn Pro Glu Pro Lys Phe 
                565                 570                 575     


Gly Gly Lys Tyr Cys Xaa Gly Glu Arg Lys Arg Tyr Arg Leu Cys Asn 
            580                 585                 590         


Val His Pro Cys Arg Ser Glu Ala Pro Xaa Phe Arg Gln Met Gln Cys 
        595                 600                 605             


Ser Glu Phe Asp Xaa Val Pro Tyr Lys Asn Glu Leu Tyr His Trp Phe 
    610                 615                 620                 


Pro Ile Phe Asn Pro Gly Tyr Val Asp Ile Gly Leu Ile Pro Lys Gly 
625                 630                 635                 640 


Ala Arg Asp Ile Arg Val Met Glu Ile Glu Gly Ala Gly Asn Phe Leu 
                645                 650                 655     


Ala Ile Arg Ser Glu Asp Pro Glu Lys Tyr Tyr Leu Asn Gly Gly Phe 
            660                 665                 670         


Ile Ile Gln Trp Asn Gly Asn Tyr Lys Leu Ala Gly Xaa Val Phe Gln 
        675                 680                 685             


Tyr Asp Arg Lys Gly Asp Leu Glu Lys Leu Met Ala Xaa Gly Pro Xaa 
    690                 695                 700                 


Asn Glu Ser Val Trp Ile Gln Leu Leu Phe Gln Val Xaa Asn Pro Gly 
705                 710                 715                 720 


Ile Lys Tyr Glu Tyr Xaa Ile Gln Lys Asp Gly Leu Asp Asn Asp Val 
                725                 730                 735     


Glu Gln Gln Met Tyr Phe Trp Gln Tyr Gly His Trp Xaa Glu Cys Ser 
            740                 745                 750         


Val Xaa Cys Gly Xaa Gly Ile Arg Arg Gln Xaa Ala His Cys Ile Lys 
        755                 760                 765             


Lys Gly Arg Gly Met Val Lys Ala Xaa Phe Cys Asp Pro Glu Xaa Gln 
    770                 775                 780                 


Pro Asn Gly Arg Gln Lys Lys Cys His Glu Lys Ala Cys Pro Pro Arg 
785                 790                 795                 800 


Trp Trp Ala Gly Glu Trp Glu Ala Cys Ser Ala Xaa Cys Gly Pro His 
                805                 810                 815     


Gly Glu Lys Lys Arg Xaa Val Leu Cys Ile Gln Xaa Met Val Ser Asp 
            820                 825                 830         


Glu Gln Ala Leu Pro Pro Xaa Asp Cys Gln His Leu Leu Lys Pro Lys 
        835                 840                 845             


Xaa Leu Leu Ser Cys Asn Arg Asp Ile Leu Cys Pro Ser Asp Trp Xaa 
    850                 855                 860                 


Val Gly Asn Trp Ser Glu Cys Ser Val Ser Cys Gly Gly Gly Val Arg 
865                 870                 875                 880 


Ile Arg Ser Val Xaa Cys Ala Lys Asn His Asp Glu Pro Cys Asp Val 
                885                 890                 895     


Xaa Arg Lys Pro Asn Ser Arg Ala Leu Cys Gly Leu Gln Gln Cys Pro 
            900                 905                 910         


Ser Ser Arg Arg Val Leu Lys Pro Asn Lys Gly Xaa Ile Ser Asn Gly 
        915                 920                 925             


Lys Asn Pro Pro Xaa Leu Lys Pro Val Pro Pro Pro Xaa Ser Arg Pro 
    930                 935                 940                 


Arg Met Leu Xaa Xaa Pro Xaa Gly Pro Glu Ser Met Ser Xaa Ser Xaa 
945                 950                 955                 960 


Pro Ala Ile Ser Ser Pro Ser Pro Xaa Xaa Ala Ser Lys Glu Gly Asp 
                965                 970                 975     


Leu Gly Gly Lys Gln Trp Gln Asp Ser Ser Xaa Gln Pro Glu Leu Ser 
            980                 985                 990         


Ser Arg Tyr Leu Ile Ser Xaa Gly  Ser Xaa Ser Gln Pro  Ile Leu Xaa 
        995                 1000                 1005             


Ser Gln  Ser Leu Ser Ile Gln  Pro Ser Glu Glu Asn  Val Ser Ser 
    1010                 1015                 1020             


Ser Asp  Xaa Gly Pro Xaa Ser  Glu Gly Gly Leu Val  Ala Xaa Xaa 
    1025                 1030                 1035             


Xaa Ser  Gly Ser Gly Leu Ser  Ser Ser Arg Asn Pro  Ile Xaa Trp 
    1040                 1045                 1050             


Pro Val  Xaa Pro Phe Tyr Asn  Xaa Leu Xaa Lys Gly  Pro Glu Met 
    1055                 1060                 1065             


Glu Ile  His Ser Gly Ser Gly  Glu Glu Arg Glu Gln  Pro Glu Asp 
    1070                 1075                 1080             


Lys Asp  Glu Ser Asn Pro Val  Ile Trp Xaa Lys Ile  Arg Val Pro 
    1085                 1090                 1095             


Gly Asn  Asp Ala Pro Val Glu  Ser Xaa Glu Met Pro  Leu Ala Pro 
    1100                 1105                 1110             


Pro Leu  Xaa Pro Asp Leu Ser  Arg Glu Ser Trp Trp  Pro Pro Phe 
    1115                 1120                 1125             


Ser Xaa  Val Met Glu Gly Leu  Leu Pro Ser Gln Arg  Pro Xaa Xaa 
    1130                 1135                 1140             


Ser Glu  Xaa Gly Xaa Pro Arg  Val Glu Gly Met Val  Xaa Glu Lys 
    1145                 1150                 1155             


Pro Ala  Asn Xaa Leu Leu Pro  Leu Gly Gly Asp His  Gln Pro Glu 
    1160                 1165                 1170             


Pro Ser  Gly Lys Xaa Ala Asn  Arg Asn His Leu Lys  Leu Pro Asn 
    1175                 1180                 1185             


Asn Met  Asn Gln Xaa Lys Ser  Ser Glu Pro Val Leu  Xaa Glu Glu 
    1190                 1195                 1200             


Asp Ala  Xaa Ser Leu Ile Xaa  Glu Gly Phe Leu Leu  Asn Ala Ser 
    1205                 1210                 1215             


Asn Tyr  Lys Gln Leu Xaa Asn  Gly His Gly Ser Ala  His Trp Ile 
    1220                 1225                 1230             


Val Gly  Asn Trp Ser Glu Cys  Ser Xaa Xaa Cys Gly  Leu Gly Ala 
    1235                 1240                 1245             


Tyr Trp  Arg Arg Val Glu Cys  Ser Xaa Gln Met Asp  Ser Asp Cys 
    1250                 1255                 1260             


Ala Ala  Ile Gln Arg Pro Asp  Pro Ala Lys Arg Cys  His Leu Arg 
    1265                 1270                 1275             


Pro Cys  Ala Gly Trp Lys Val  Gly Asn Trp Ser Lys  Cys Ser Arg 
    1280                 1285                 1290             


Asn Cys  Ser Gly Gly Phe Lys  Ile Arg Glu Ile Gln  Cys Val Asp 
    1295                 1300                 1305             


Ser Arg  Asp His Arg Asn Leu  Arg Pro Phe His Cys  Gln Phe Leu 
    1310                 1315                 1320             


Ala Gly  Ile Pro Pro Pro Leu  Ser Met Ser Cys Asn  Pro Glu Pro 
    1325                 1330                 1335             


Cys Glu  Ala Trp Gln Val Glu  Pro Trp Ser Gln Cys  Ser Arg Ser 
    1340                 1345                 1350             


Cys Gly  Gly Gly Val Gln Glu  Arg Gly Val Phe Cys  Pro Gly Gly 
    1355                 1360                 1365             


Leu Cys  Asp Trp Xaa Lys Arg  Pro Xaa Ser Xaa Met  Ser Cys Asn 
    1370                 1375                 1380             


Glu His  Leu Cys Cys His Trp  Ala Xaa Gly Asn Trp  Asp Leu Cys 
    1385                 1390                 1395             


Ser Xaa  Ser Cys Gly Gly Gly  Phe Gln Lys Arg Xaa  Val Gln Cys 
    1400                 1405                 1410             


Val Pro  Ser Glu Gly Asn Lys  Xaa Glu Asp Gln Asp  Gln Cys Leu 
    1415                 1420                 1425             


Cys Asp  His Lys Pro Arg Pro  Pro Glu Phe Lys Lys  Cys Asn Gln 
    1430                 1435                 1440             


Gln Ala  Cys Lys Lys Ser Ala  Asp Leu Leu Cys Xaa  Lys Asp Lys 
    1445                 1450                 1455             


Leu Ser  Ala Ser Phe Cys Gln  Xaa Leu Lys Ala Met  Lys Lys Cys 
    1460                 1465                 1470             


Ser Val  Pro Xaa Val Arg Ala  Glu Cys Cys Phe Ser  Cys Pro Gln 
    1475                 1480                 1485             


Xaa His  Ile Xaa His Xaa Gln  Arg Gln Arg Arg Gln  Arg Leu Leu 
    1490                 1495                 1500             


Gln Lys  Ser Lys Glu Leu 
    1505                 


<210> 1515
<211> 1594
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1093)..(1093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1247)..(1247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1278)..(1278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1291)..(1291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1327)..(1328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1342)..(1342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1462)..(1462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1464)..(1464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1477)..(1477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1485)..(1485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1495)..(1495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1540)..(1540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1551)..(1551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1562)..(1562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1577)..(1577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1579)..(1579)
<223> Selenocysteine

<400> 1515
Met Pro Cys Ala Gln Arg Ser Trp Leu Ala Asn Leu Ser Val Val Ala 
1               5                   10                  15      


Gln Leu Leu Asn Phe Gly Ala Leu Cys Tyr Gly Arg Gln Pro Gln Pro 
            20                  25                  30          


Gly Pro Val Arg Phe Pro Asp Arg Arg Gln Glu His Phe Ile Lys Gly 
        35                  40                  45              


Leu Pro Glu Tyr His Val Val Gly Pro Val Arg Val Asp Ala Ser Gly 
    50                  55                  60                  


His Phe Leu Ser Tyr Gly Leu His Tyr Pro Ile Xaa Ser Ser Arg Arg 
65                  70                  75                  80  


Lys Arg Asp Leu Asp Gly Ser Glu Asp Trp Val Tyr Tyr Arg Ile Ser 
                85                  90                  95      


His Glu Glu Lys Asp Leu Phe Phe Asn Leu Xaa Val Asn Gln Gly Phe 
            100                 105                 110         


Leu Ser Asn Ser Tyr Ile Met Glu Lys Arg Tyr Gly Asn Leu Ser His 
        115                 120                 125             


Val Lys Met Met Ala Ser Ser Ala Pro Leu Cys His Leu Ser Gly Xaa 
    130                 135                 140                 


Val Leu Gln Gln Gly Xaa Arg Val Gly Xaa Ala Ala Leu Ser Ala Cys 
145                 150                 155                 160 


His Gly Leu Xaa Gly Phe Phe Gln Leu Pro His Gly Asp Phe Phe Ile 
                165                 170                 175     


Glu Pro Val Lys Lys His Pro Leu Val Glu Gly Gly Tyr His Pro His 
            180                 185                 190         


Ile Val Tyr Arg Arg Gln Lys Val Pro Glu Xaa Lys Glu Pro Xaa Cys 
        195                 200                 205             


Gly Leu Lys Asp Ser Val Asn Ile Ser Gln Lys Gln Glu Leu Trp Arg 
    210                 215                 220                 


Glu Lys Trp Glu Arg His Asn Leu Pro Ser Arg Ser Leu Ser Arg Arg 
225                 230                 235                 240 


Ser Ile Ser Lys Glu Arg Trp Val Glu Xaa Leu Val Val Ala Asp Xaa 
                245                 250                 255     


Lys Met Ile Glu Tyr His Gly Ser Glu Asn Val Glu Ser Tyr Ile Leu 
            260                 265                 270         


Xaa Ile Met Asn Met Val Xaa Gly Leu Phe His Asn Pro Ser Ile Gly 
        275                 280                 285             


Asn Ala Ile His Ile Val Val Val Arg Leu Ile Leu Leu Glu Glu Glu 
    290                 295                 300                 


Glu Gln Gly Leu Lys Ile Val His His Ala Glu Lys Xaa Leu Ser Ser 
305                 310                 315                 320 


Phe Cys Lys Trp Gln Lys Ser Ile Asn Pro Lys Ser Asp Leu Asn Pro 
                325                 330                 335     


Val His His Asp Val Ala Val Leu Leu Xaa Arg Lys Asp Ile Cys Ala 
            340                 345                 350         


Gly Phe Asn Arg Pro Cys Glu Xaa Leu Gly Leu Ser His Leu Ser Gly 
        355                 360                 365             


Met Cys Gln Pro His Arg Ser Cys Asn Ile Asn Glu Asp Ser Gly Leu 
    370                 375                 380                 


Pro Leu Ala Phe Xaa Ile Ala His Glu Leu Gly His Ser Phe Gly Ile 
385                 390                 395                 400 


Gln His Asp Gly Lys Glu Asn Asp Cys Glu Pro Val Gly Arg His Pro 
                405                 410                 415     


Tyr Ile Met Ser Arg Gln Leu Gln Tyr Asp Pro Xaa Pro Leu Xaa Trp 
            420                 425                 430         


Ser Lys Cys Ser Glu Glu Tyr Ile Xaa Arg Phe Leu Asp Arg Gly Trp 
        435                 440                 445             


Gly Phe Cys Leu Asp Asp Ile Pro Lys Lys Lys Gly Leu Lys Ser Lys 
    450                 455                 460                 


Val Ile Ala Pro Gly Val Ile Tyr Asp Val His His Gln Cys Gln Leu 
465                 470                 475                 480 


Gln Tyr Gly Pro Asn Ala Xaa Phe Cys Gln Glu Val Glu Asn Val Cys 
                485                 490                 495     


Gln Xaa Leu Trp Cys Ser Val Lys Gly Phe Cys Arg Ser Lys Leu Asp 
            500                 505                 510         


Ala Ala Ala Asp Gly Xaa Gln Cys Gly Glu Lys Lys Trp Cys Met Ala 
        515                 520                 525             


Gly Lys Cys Ile Xaa Val Gly Lys Lys Pro Glu Ser Ile Pro Gly Gly 
    530                 535                 540                 


Trp Gly Arg Trp Ser Pro Trp Ser His Cys Ser Arg Xaa Cys Gly Ala 
545                 550                 555                 560 


Gly Val Gln Ser Ala Glu Arg Leu Cys Asn Asn Pro Glu Pro Lys Phe 
                565                 570                 575     


Gly Gly Lys Tyr Cys Xaa Gly Glu Arg Lys Arg Tyr Arg Leu Cys Asn 
            580                 585                 590         


Val His Pro Cys Arg Ser Glu Ala Pro Xaa Phe Arg Gln Met Gln Cys 
        595                 600                 605             


Ser Glu Phe Asp Xaa Val Pro Tyr Lys Asn Glu Leu Tyr His Trp Phe 
    610                 615                 620                 


Pro Ile Phe Asn Pro Ala His Pro Cys Glu Leu Tyr Cys Arg Pro Ile 
625                 630                 635                 640 


Asp Gly Gln Phe Ser Glu Lys Met Leu Asp Ala Val Ile Asp Gly Xaa 
                645                 650                 655     


Pro Cys Phe Glu Gly Gly Asn Ser Arg Asn Val Cys Ile Asn Gly Ile 
            660                 665                 670         


Cys Lys Met Val Gly Cys Asp Tyr Glu Ile Asp Ser Asn Ala Xaa Glu 
        675                 680                 685             


Asp Arg Cys Gly Val Cys Leu Gly Asp Gly Ser Ser Cys Gln Xaa Val 
    690                 695                 700                 


Arg Lys Met Phe Lys Gln Lys Glu Gly Ser Gly Tyr Val Asp Ile Gly 
705                 710                 715                 720 


Leu Ile Pro Lys Gly Ala Arg Asp Ile Arg Val Met Glu Ile Glu Gly 
                725                 730                 735     


Ala Gly Asn Phe Leu Ala Ile Arg Ser Glu Asp Pro Glu Lys Tyr Tyr 
            740                 745                 750         


Leu Asn Gly Gly Phe Ile Ile Gln Trp Asn Gly Asn Tyr Lys Leu Ala 
        755                 760                 765             


Gly Xaa Val Phe Gln Tyr Asp Arg Lys Gly Asp Leu Glu Lys Leu Met 
    770                 775                 780                 


Ala Xaa Gly Pro Xaa Asn Glu Ser Val Trp Ile Gln Leu Leu Phe Gln 
785                 790                 795                 800 


Val Xaa Asn Pro Gly Ile Lys Tyr Glu Tyr Xaa Ile Gln Lys Asp Gly 
                805                 810                 815     


Leu Asp Asn Asp Val Glu Gln Gln Met Tyr Phe Trp Gln Tyr Gly His 
            820                 825                 830         


Trp Xaa Glu Cys Ser Val Xaa Cys Gly Xaa Gly Ile Arg Arg Gln Xaa 
        835                 840                 845             


Ala His Cys Ile Lys Lys Gly Arg Gly Met Val Lys Ala Xaa Phe Cys 
    850                 855                 860                 


Asp Pro Glu Xaa Gln Pro Asn Gly Arg Gln Lys Lys Cys His Glu Lys 
865                 870                 875                 880 


Ala Cys Pro Pro Arg Trp Trp Ala Gly Glu Trp Glu Ala Cys Ser Ala 
                885                 890                 895     


Xaa Cys Gly Pro His Gly Glu Lys Lys Arg Xaa Val Leu Cys Ile Gln 
            900                 905                 910         


Xaa Met Val Ser Asp Glu Gln Ala Leu Pro Pro Xaa Asp Cys Gln His 
        915                 920                 925             


Leu Leu Lys Pro Lys Xaa Leu Leu Ser Cys Asn Arg Asp Ile Leu Cys 
    930                 935                 940                 


Pro Ser Asp Trp Xaa Val Gly Asn Trp Ser Glu Cys Ser Val Ser Cys 
945                 950                 955                 960 


Gly Gly Gly Val Arg Ile Arg Ser Val Xaa Cys Ala Lys Asn His Asp 
                965                 970                 975     


Glu Pro Cys Asp Val Xaa Arg Lys Pro Asn Ser Arg Ala Leu Cys Gly 
            980                 985                 990         


Leu Gln Gln Cys Pro Ser Ser Arg  Arg Val Leu Lys Pro  Asn Lys Gly 
        995                 1000                 1005             


Xaa Ile  Ser Asn Gly Lys Asn  Pro Pro Xaa Leu Lys  Pro Val Pro 
    1010                 1015                 1020             


Pro Pro  Xaa Ser Arg Pro Arg  Met Leu Xaa Xaa Pro  Xaa Gly Pro 
    1025                 1030                 1035             


Glu Ser  Met Ser Xaa Ser Xaa  Pro Ala Ile Ser Ser  Pro Ser Pro 
    1040                 1045                 1050             


Xaa Xaa  Ala Ser Lys Glu Gly  Asp Leu Gly Gly Lys  Gln Trp Gln 
    1055                 1060                 1065             


Asp Ser  Ser Xaa Gln Pro Glu  Leu Ser Ser Arg Tyr  Leu Ile Ser 
    1070                 1075                 1080             


Xaa Gly  Ser Xaa Ser Gln Pro  Ile Leu Xaa Ser Gln  Ser Leu Ser 
    1085                 1090                 1095             


Ile Gln  Pro Ser Glu Glu Asn  Val Ser Ser Ser Asp  Xaa Gly Pro 
    1100                 1105                 1110             


Xaa Ser  Glu Gly Gly Leu Val  Ala Xaa Xaa Xaa Ser  Gly Ser Gly 
    1115                 1120                 1125             


Leu Ser  Ser Ser Arg Asn Pro  Ile Xaa Trp Pro Val  Xaa Pro Phe 
    1130                 1135                 1140             


Tyr Asn  Xaa Leu Xaa Lys Gly  Pro Glu Met Glu Ile  His Ser Gly 
    1145                 1150                 1155             


Ser Gly  Glu Glu Arg Glu Gln  Pro Glu Asp Lys Asp  Glu Ser Asn 
    1160                 1165                 1170             


Pro Val  Ile Trp Xaa Lys Ile  Arg Val Pro Gly Asn  Asp Ala Pro 
    1175                 1180                 1185             


Val Glu  Ser Xaa Glu Met Pro  Leu Ala Pro Pro Leu  Xaa Pro Asp 
    1190                 1195                 1200             


Leu Ser  Arg Glu Ser Trp Trp  Pro Pro Phe Ser Xaa  Val Met Glu 
    1205                 1210                 1215             


Gly Leu  Leu Pro Ser Gln Arg  Pro Xaa Xaa Ser Glu  Xaa Gly Xaa 
    1220                 1225                 1230             


Pro Arg  Val Glu Gly Met Val  Xaa Glu Lys Pro Ala  Asn Xaa Leu 
    1235                 1240                 1245             


Leu Pro  Leu Gly Gly Asp His  Gln Pro Glu Pro Ser  Gly Lys Xaa 
    1250                 1255                 1260             


Ala Asn  Arg Asn His Leu Lys  Leu Pro Asn Asn Met  Asn Gln Xaa 
    1265                 1270                 1275             


Lys Ser  Ser Glu Pro Val Leu  Xaa Glu Glu Asp Ala  Xaa Ser Leu 
    1280                 1285                 1290             


Ile Xaa  Glu Gly Phe Leu Leu  Asn Ala Ser Asn Tyr  Lys Gln Leu 
    1295                 1300                 1305             


Xaa Asn  Gly His Gly Ser Ala  His Trp Ile Val Gly  Asn Trp Ser 
    1310                 1315                 1320             


Glu Cys  Ser Xaa Xaa Cys Gly  Leu Gly Ala Tyr Trp  Arg Arg Val 
    1325                 1330                 1335             


Glu Cys  Ser Xaa Gln Met Asp  Ser Asp Cys Ala Ala  Ile Gln Arg 
    1340                 1345                 1350             


Pro Asp  Pro Ala Lys Arg Cys  His Leu Arg Pro Cys  Ala Gly Trp 
    1355                 1360                 1365             


Lys Val  Gly Asn Trp Ser Lys  Cys Ser Arg Asn Cys  Ser Gly Gly 
    1370                 1375                 1380             


Phe Lys  Ile Arg Glu Ile Gln  Cys Val Asp Ser Arg  Asp His Arg 
    1385                 1390                 1395             


Asn Leu  Arg Pro Phe His Cys  Gln Phe Leu Ala Gly  Ile Pro Pro 
    1400                 1405                 1410             


Pro Leu  Ser Met Ser Cys Asn  Pro Glu Pro Cys Glu  Ala Trp Gln 
    1415                 1420                 1425             


Val Glu  Pro Trp Ser Gln Cys  Ser Arg Ser Cys Gly  Gly Gly Val 
    1430                 1435                 1440             


Gln Glu  Arg Gly Val Phe Cys  Pro Gly Gly Leu Cys  Asp Trp Xaa 
    1445                 1450                 1455             


Lys Arg  Pro Xaa Ser Xaa Met  Ser Cys Asn Glu His  Leu Cys Cys 
    1460                 1465                 1470             


His Trp  Ala Xaa Gly Asn Trp  Asp Leu Cys Ser Xaa  Ser Cys Gly 
    1475                 1480                 1485             


Gly Gly  Phe Gln Lys Arg Xaa  Val Gln Cys Val Pro  Ser Glu Gly 
    1490                 1495                 1500             


Asn Lys  Xaa Glu Asp Gln Asp  Gln Cys Leu Cys Asp  His Lys Pro 
    1505                 1510                 1515             


Arg Pro  Pro Glu Phe Lys Lys  Cys Asn Gln Gln Ala  Cys Lys Lys 
    1520                 1525                 1530             


Ser Ala  Asp Leu Leu Cys Xaa  Lys Asp Lys Leu Ser  Ala Ser Phe 
    1535                 1540                 1545             


Cys Gln  Xaa Leu Lys Ala Met  Lys Lys Cys Ser Val  Pro Xaa Val 
    1550                 1555                 1560             


Arg Ala  Glu Cys Cys Phe Ser  Cys Pro Gln Xaa His  Ile Xaa His 
    1565                 1570                 1575             


Xaa Gln  Arg Gln Arg Arg Gln  Arg Leu Leu Gln Lys  Ser Lys Glu 
    1580                 1585                 1590             


Leu 
    


<210> 1516
<211> 232
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<400> 1516
Met Pro Cys Ala Gln Arg Ser Trp Leu Ala Asn Leu Ser Val Val Ala 
1               5                   10                  15      


Gln Leu Leu Asn Phe Gly Ala Leu Cys Tyr Gly Arg Gln Pro Gln Pro 
            20                  25                  30          


Gly Pro Val Arg Phe Pro Asp Arg Arg Gln Glu His Phe Ile Lys Gly 
        35                  40                  45              


Leu Pro Glu Tyr His Val Val Gly Pro Val Arg Val Asp Ala Ser Gly 
    50                  55                  60                  


His Phe Leu Ser Tyr Gly Leu His Tyr Pro Ile Xaa Ser Ser Arg Arg 
65                  70                  75                  80  


Lys Arg Asp Leu Asp Gly Ser Glu Asp Trp Val Tyr Tyr Arg Ile Ser 
                85                  90                  95      


His Glu Glu Lys Asp Leu Phe Phe Asn Leu Xaa Val Asn Gln Gly Phe 
            100                 105                 110         


Leu Ser Asn Ser Tyr Ile Met Glu Lys Arg Tyr Gly Asn Leu Ser His 
        115                 120                 125             


Val Lys Met Met Ala Ser Ser Ala Pro Leu Cys His Leu Ser Gly Xaa 
    130                 135                 140                 


Val Leu Gln Gln Gly Xaa Arg Val Gly Xaa Ala Ala Leu Ser Ala Cys 
145                 150                 155                 160 


His Gly Leu Xaa Gly Phe Phe Gln Leu Pro His Gly Asp Phe Phe Ile 
                165                 170                 175     


Glu Pro Val Lys Lys His Pro Leu Val Glu Gly Gly Tyr His Pro His 
            180                 185                 190         


Ile Val Tyr Arg Arg Gln Lys Val Pro Glu Xaa Lys Glu Pro Xaa Cys 
        195                 200                 205             


Gly Leu Lys Gly Ile Val Xaa His Met Ser Ser Trp Val Glu Glu Ser 
    210                 215                 220                 


Val Leu Phe Phe Trp Leu Phe Tyr 
225                 230         


<210> 1517
<211> 444
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<400> 1517
Met Ala Ser Asp Gly Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro 
1               5                   10                  15      


Cys Ser Arg Arg Gln Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala Arg 
            20                  25                  30          


Cys Val Trp Asp Pro Pro Arg Pro Gln Pro Gly Ser Ala Gly His Pro 
        35                  40                  45              


Pro Asp Ala Gln Pro Gly Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg 
    50                  55                  60                  


Val Ala Phe Gly Pro Lys Ala Val Ala Cys Xaa Phe Ala Arg Glu His 
65                  70                  75                  80  


Leu Asp Met Cys Gln Ala Leu Ser Cys His Xaa Asp Pro Leu Asp Gln 
                85                  90                  95      


Ser Ser Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Xaa Glu Cys 
            100                 105                 110         


Gly Val Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu 
        115                 120                 125             


Leu Xaa Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro 
    130                 135                 140                 


Arg Ser Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Xaa Arg Arg 
145                 150                 155                 160 


Arg Gln Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val 
                165                 170                 175     


Gly Ala Asp Leu Gln Ala Glu Met Cys Asn Xaa Gln Ala Cys Glu Lys 
            180                 185                 190         


Xaa Gln Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Xaa Asp Gly Gln 
        195                 200                 205             


Pro Leu Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala 
    210                 215                 220                 


Ala Val Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg 
225                 230                 235                 240 


Ala Ile Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp 
                245                 250                 255     


Gly Xaa Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Xaa Leu Ser 
            260                 265                 270         


Leu Cys Val Ser Gly Ser Cys Arg Xaa Phe Gly Cys Asp Gly Arg Met 
        275                 280                 285             


Asp Ser Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn 
    290                 295                 300                 


Ser Xaa Cys Ser Pro Arg Lys Gly Ser Phe Xaa Ala Gly Arg Ala Arg 
305                 310                 315                 320 


Glu Tyr Val Xaa Phe Leu Xaa Val Xaa Pro Asn Leu Xaa Ser Val Tyr 
                325                 330                 335     


Ile Ala Asn His Arg Pro Leu Phe Xaa His Leu Ala Val Arg Ile Gly 
            340                 345                 350         


Gly Arg Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Xaa Xaa 
        355                 360                 365             


Tyr Pro Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu 
    370                 375                 380                 


Xaa Glu Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro 
385                 390                 395                 400 


Leu Gln Glu Asp Ala Asp Ile Gln Val Gly Gly Val Arg Ala Gln Leu 
                405                 410                 415     


Met His Ile Ser Trp Trp Ser Arg Pro Gly Leu Gly Glu Arg Asp Leu 
            420                 425                 430         


Cys Ala Arg Gly Arg Trp Pro Gly Gly Ser Ser Asp 
        435                 440                 


<210> 1518
<211> 276
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<400> 1518
Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Xaa Glu Arg Tyr Val Leu Xaa Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Xaa Glu Pro Glu Gly Ala Pro Asn Ile Xaa 
    130                 135                 140                 


Ala Asn Leu Xaa Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Xaa 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Xaa Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Xaa Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Xaa Gln Leu Gly Gly Ala Cys Ser Pro Xaa Trp Ser Cys 
        195                 200                 205             


Leu Ile Xaa Glu Asp Xaa Gly Phe Asp Leu Gly Val Xaa Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Arg Ile Cys Ala Arg Pro Ser Pro Ala Xaa Gln Xaa 
225                 230                 235                 240 


Arg Trp Xaa Lys Ala Ala Ala Ala Ala Ser Ser Phe Leu Ser Trp Met 
                245                 250                 255     


Gly Gln Asn Val Ala Trp Arg Ser Gly Ala Pro Arg Val Ala Ala Ala 
            260                 265                 270         


Pro Trp Trp Ser 
        275     


<210> 1519
<211> 344
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<400> 1519
Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Xaa Glu Arg Tyr Val Leu Xaa Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Xaa Glu Pro Glu Gly Ala Pro Asn Ile Xaa 
    130                 135                 140                 


Ala Asn Leu Xaa Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Xaa 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Xaa Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Xaa Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Xaa Gln Leu Gly Gly Ala Cys Ser Pro Xaa Trp Ser Cys 
        195                 200                 205             


Leu Ile Xaa Glu Asp Xaa Gly Phe Asp Leu Gly Val Xaa Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Arg Pro Val Pro Pro Ser Pro Leu Pro Leu Leu Ala Xaa His 
        275                 280                 285             


Leu Cys Ala Gly Arg Ser Leu Ser Leu Gly Pro Ser Gln Glu Pro Ala 
    290                 295                 300                 


Pro Gly Gly Gly Arg Gly Pro Arg Xaa Pro Val Pro Xaa His Lys Arg 
305                 310                 315                 320 


Pro Arg Phe Gln Xaa Leu Pro Ser Ser Cys Pro Leu Leu Arg Pro Ala 
                325                 330                 335     


Ser Ser Arg Cys Xaa Pro Arg Asp 
            340                 


<210> 1520
<211> 1340
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1179)..(1179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1276)..(1276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1281)..(1282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1320)..(1320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1340)..(1340)
<223> Selenocysteine

<400> 1520
Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Xaa Glu Arg Tyr Val Leu Xaa Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Xaa Glu Pro Glu Gly Ala Pro Asn Ile Xaa 
    130                 135                 140                 


Ala Asn Leu Xaa Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Xaa 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Xaa Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Xaa Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Xaa Gln Leu Gly Gly Ala Cys Ser Pro Xaa Trp Ser Cys 
        195                 200                 205             


Leu Ile Xaa Glu Asp Xaa Gly Phe Asp Leu Gly Val Xaa Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala 
        275                 280                 285             


Val Ala Cys Xaa Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu 
    290                 295                 300                 


Ser Cys His Xaa Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu 
305                 310                 315                 320 


Val Pro Leu Leu Asp Gly Xaa Glu Cys Gly Val Glu Lys Trp Cys Ser 
                325                 330                 335     


Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Xaa Pro Ile Ala Ala Val 
            340                 345                 350         


His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser 
        355                 360                 365             


Cys Gly Gly Gly Val Val Xaa Arg Arg Arg Gln Cys Asn Asn Pro Arg 
    370                 375                 380                 


Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu 
385                 390                 395                 400 


Met Cys Asn Xaa Gln Ala Cys Glu Lys Xaa Gln Leu Glu Phe Met Ser 
                405                 410                 415     


Gln Gln Cys Ala Arg Xaa Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly 
            420                 425                 430         


Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly 
        435                 440                 445             


Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile 
    450                 455                 460                 


Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Xaa Arg Cys Met Pro Ser 
465                 470                 475                 480 


Gly Pro Arg Glu Asp Gly Xaa Leu Ser Leu Cys Val Ser Gly Ser Cys 
                485                 490                 495     


Arg Xaa Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp 
            500                 505                 510         


Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Xaa Cys Ser Pro Arg Lys 
        515                 520                 525             


Gly Ser Phe Xaa Ala Gly Arg Ala Arg Glu Tyr Val Xaa Phe Leu Xaa 
    530                 535                 540                 


Val Xaa Pro Asn Leu Xaa Ser Val Tyr Ile Ala Asn His Arg Pro Leu 
545                 550                 555                 560 


Phe Xaa His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly 
                565                 570                 575     


Lys Met Ser Ile Ser Pro Asn Xaa Xaa Tyr Pro Ser Leu Leu Glu Asp 
            580                 585                 590         


Gly Arg Val Glu Tyr Arg Val Ala Leu Xaa Glu Asp Arg Leu Pro Arg 
        595                 600                 605             


Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile 
    610                 615                 620                 


Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Xaa Arg Pro 
625                 630                 635                 640 


Asp Ile Xaa Phe Xaa Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val 
                645                 650                 655     


Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu 
            660                 665                 670         


Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val 
        675                 680                 685             


Glu Xaa Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu 
    690                 695                 700                 


Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe 
705                 710                 715                 720 


Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val 
                725                 730                 735     


Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Xaa Leu Pro Pro Ala 
            740                 745                 750         


Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Xaa Cys 
        755                 760                 765             


Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser 
    770                 775                 780                 


Cys Xaa Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Xaa Cys 
785                 790                 795                 800 


Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Xaa Glu Gly Pro Gly 
                805                 810                 815     


Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser 
            820                 825                 830         


Cys Pro Pro Gly Trp Gly His Leu Asp Ala Xaa Ser Ala Gly Glu Lys 
        835                 840                 845             


Ala Pro Ser Pro Trp Gly Ser Ile Arg Xaa Gly Ala Gln Ala Ala His 
    850                 855                 860                 


Val Trp Xaa Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly 
865                 870                 875                 880 


Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro 
                885                 890                 895     


Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg 
            900                 905                 910         


Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu 
        915                 920                 925             


Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu 
    930                 935                 940                 


Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu 
945                 950                 955                 960 


Asp Xaa Gln Cys Gln Gly Leu Pro Arg Pro Glu Pro Gln Glu Ala Cys 
                965                 970                 975     


Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val Met Ser Leu Gly Pro 
            980                 985                 990         


Cys Ser Ala Ser Cys Gly Leu Gly  Xaa Ala Arg Arg Ser  Val Ala Cys 
        995                 1000                 1005             


Val Gln  Leu Asp Gln Gly Gln  Asp Val Glu Val Asp  Glu Ala Ala 
    1010                 1015                 1020             


Cys Ala  Ala Leu Val Arg Pro  Glu Ala Ser Val Pro  Cys Leu Ile 
    1025                 1030                 1035             


Ala Asp  Cys Xaa Tyr Arg Trp  His Val Gly Xaa Trp  Met Glu Cys 
    1040                 1045                 1050             


Ser Val  Ser Cys Gly Asp Gly  Ile Gln Arg Arg Arg  Asp Xaa Cys 
    1055                 1060                 1065             


Leu Gly  Pro Gln Ala Gln Ala  Pro Val Pro Ala Asp  Phe Cys Gln 
    1070                 1075                 1080             


His Leu  Pro Lys Pro Val Xaa  Val Arg Gly Cys Trp  Ala Gly Pro 
    1085                 1090                 1095             


Cys Val  Gly Gln Gly Ala Cys  Gly Arg Gln His Leu  Glu Pro Xaa 
    1100                 1105                 1110             


Gly Xaa  Ile Asp Met Arg Gly  Pro Gly Gln Ala Asp  Cys Ala Val 
    1115                 1120                 1125             


Ala Ile  Gly Arg Pro Leu Gly  Glu Val Val Xaa Leu  Arg Val Leu 
    1130                 1135                 1140             


Glu Ser  Ser Leu Asn Cys Ser  Ala Gly Asp Met Leu  Leu Leu Trp 
    1145                 1150                 1155             


Gly Arg  Leu Xaa Trp Arg Lys  Met Cys Arg Lys Leu  Leu Asp Met 
    1160                 1165                 1170             


Xaa Phe  Ser Ser Lys Xaa Asn  Xaa Leu Val Val Arg  Gln Arg Cys 
    1175                 1180                 1185             


Gly Arg  Pro Gly Gly Gly Val  Leu Leu Arg Tyr Gly  Ser Gln Leu 
    1190                 1195                 1200             


Ala Pro  Glu Xaa Phe Tyr Arg  Glu Cys Asp Met Gln  Leu Phe Gly 
    1205                 1210                 1215             


Pro Trp  Gly Glu Ile Val Ser  Pro Ser Leu Ser Pro  Ala Xaa Ser 
    1220                 1225                 1230             


Asn Ala  Gly Gly Cys Arg Leu  Phe Ile Asn Val Ala  Pro His Ala 
    1235                 1240                 1245             


Arg Ile  Ala Ile His Ala Leu  Ala Xaa Asn Met Gly  Ala Gly Xaa 
    1250                 1255                 1260             


Glu Gly  Ala Asn Ala Ser Tyr  Ile Leu Ile Arg Asp  Xaa His Ser 
    1265                 1270                 1275             


Leu Arg  Xaa Xaa Ala Phe His  Gly Gln Gln Val Leu  Tyr Trp Glu 
    1280                 1285                 1290             


Ser Glu  Ser Ser Gln Ala Glu  Met Glu Phe Ser Glu  Gly Phe Leu 
    1295                 1300                 1305             


Lys Ala  Gln Ala Ser Leu Arg  Gly Gln Tyr Trp Xaa  Leu Gln Ser 
    1310                 1315                 1320             


Trp Val  Pro Glu Met Gln Asp  Pro Gln Ser Trp Lys  Gly Lys Glu 
    1325                 1330                 1335             


Gly Xaa  
    1340 


<210> 1521
<211> 1371
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1193)..(1193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1238)..(1238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1294)..(1294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<400> 1521
Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Xaa Glu Arg Tyr Val Leu Xaa Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Xaa Glu Pro Glu Gly Ala Pro Asn Ile Xaa 
    130                 135                 140                 


Ala Asn Leu Xaa Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Xaa 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Xaa Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Xaa Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Xaa Gln Leu Gly Gly Ala Cys Ser Pro Xaa Trp Ser Cys 
        195                 200                 205             


Leu Ile Xaa Glu Asp Xaa Gly Phe Asp Leu Gly Val Xaa Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Xaa Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Xaa Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Xaa Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Xaa Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Xaa Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Xaa Gln Ala Cys Glu Lys Xaa Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Xaa Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Xaa Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Xaa Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Xaa Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Xaa Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Xaa Ala Gly Arg Ala Arg Glu Tyr Val Xaa Phe Leu Xaa Val 
                565                 570                 575     


Xaa Pro Asn Leu Xaa Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Xaa His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Xaa Xaa Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Xaa Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Xaa Arg Pro Asp 
            660                 665                 670         


Ile Xaa Phe Xaa Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Xaa Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Xaa Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Xaa Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Xaa Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Xaa Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Xaa Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Xaa Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Xaa Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Xaa Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Xaa Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Xaa Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Xaa Tyr Arg  Trp His Val Gly Xaa  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Xaa 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Xaa Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Ala  Cys Gly Arg Gln His  Leu Glu Pro 
    1130                 1135                 1140             


Xaa Gly  Xaa Ile Asp Met Arg  Gly Pro Gly Gln Ala  Asp Cys Ala 
    1145                 1150                 1155             


Val Ala  Ile Gly Arg Pro Leu  Gly Glu Val Val Xaa  Leu Arg Val 
    1160                 1165                 1170             


Leu Glu  Ser Ser Leu Asn Cys  Ser Ala Gly Asp Met  Leu Leu Leu 
    1175                 1180                 1185             


Trp Gly  Arg Leu Xaa Trp Arg  Lys Met Cys Arg Lys  Leu Leu Asp 
    1190                 1195                 1200             


Met Xaa  Phe Ser Ser Lys Xaa  Asn Xaa Leu Val Val  Arg Gln Arg 
    1205                 1210                 1215             


Cys Gly  Arg Pro Gly Gly Gly  Val Leu Leu Arg Tyr  Gly Ser Gln 
    1220                 1225                 1230             


Leu Ala  Pro Glu Xaa Phe Tyr  Arg Glu Cys Asp Met  Gln Leu Phe 
    1235                 1240                 1245             


Gly Pro  Trp Gly Glu Ile Val  Ser Pro Ser Leu Ser  Pro Ala Xaa 
    1250                 1255                 1260             


Ser Asn  Ala Gly Gly Cys Arg  Leu Phe Ile Asn Val  Ala Pro His 
    1265                 1270                 1275             


Ala Arg  Ile Ala Ile His Ala  Leu Ala Xaa Asn Met  Gly Ala Gly 
    1280                 1285                 1290             


Xaa Glu  Gly Ala Asn Ala Ser  Tyr Ile Leu Ile Arg  Asp Xaa His 
    1295                 1300                 1305             


Ser Leu  Arg Xaa Xaa Ala Phe  His Gly Gln Gln Val  Leu Tyr Trp 
    1310                 1315                 1320             


Glu Ser  Glu Ser Ser Gln Ala  Glu Met Glu Phe Ser  Glu Gly Phe 
    1325                 1330                 1335             


Leu Lys  Ala Gln Ala Ser Leu  Arg Gly Gln Tyr Trp  Xaa Leu Gln 
    1340                 1345                 1350             


Ser Trp  Val Pro Glu Met Gln  Asp Pro Gln Ser Trp  Lys Gly Lys 
    1355                 1360                 1365             


Glu Gly  Xaa 
    1370     


<210> 1522
<211> 1427
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1200)..(1200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1226)..(1226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1268)..(1268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1294)..(1294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1319)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1344)..(1344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1363)..(1363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1368)..(1369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<400> 1522
Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Xaa Glu Arg Tyr Val Leu Xaa Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Xaa Glu Pro Glu Gly Ala Pro Asn Ile Xaa 
    130                 135                 140                 


Ala Asn Leu Xaa Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Xaa 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Xaa Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Xaa Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Xaa Gln Leu Gly Gly Ala Cys Ser Pro Xaa Trp Ser Cys 
        195                 200                 205             


Leu Ile Xaa Glu Asp Xaa Gly Phe Asp Leu Gly Val Xaa Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Xaa Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Xaa Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Xaa Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Xaa Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Xaa Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Xaa Gln Ala Cys Glu Lys Xaa Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Xaa Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Xaa Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Xaa Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Xaa Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Xaa Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Xaa Ala Gly Arg Ala Arg Glu Tyr Val Xaa Phe Leu Xaa Val 
                565                 570                 575     


Xaa Pro Asn Leu Xaa Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Xaa His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Xaa Xaa Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Xaa Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Xaa Arg Pro Asp 
            660                 665                 670         


Ile Xaa Phe Xaa Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Xaa Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Xaa Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Xaa Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Xaa Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Xaa Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Xaa Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Xaa Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Xaa Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Xaa Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Xaa Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Xaa Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Xaa Tyr Arg  Trp His Val Gly Xaa  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Xaa 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Xaa Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Xaa  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Xaa  Xaa Ala Xaa Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Xaa  Gly Xaa Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Xaa Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Xaa Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Xaa Phe Ser 
    1250                 1255                 1260             


Ser Lys  Xaa Asn Xaa Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Xaa Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Xaa Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Xaa Asn  Met Gly Ala Gly Xaa  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Xaa His Ser  Leu Arg Xaa 
    1355                 1360                 1365             


Xaa Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Xaa Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Xaa 
    1415                 1420                 1425         


<210> 1523
<211> 223
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<400> 1523
Met Arg Gly Pro Gly Gln Ala Asp Cys Ala Val Ala Ile Gly Arg Pro 
1               5                   10                  15      


Leu Gly Glu Val Val Xaa Leu Arg Val Leu Glu Ser Ser Leu Asn Cys 
            20                  25                  30          


Ser Ala Gly Asp Met Leu Leu Leu Trp Gly Arg Leu Xaa Trp Arg Lys 
        35                  40                  45              


Met Cys Arg Lys Leu Leu Asp Met Xaa Phe Ser Ser Lys Xaa Asn Xaa 
    50                  55                  60                  


Leu Val Val Arg Gln Arg Cys Gly Arg Pro Gly Gly Gly Val Leu Leu 
65                  70                  75                  80  


Arg Tyr Gly Ser Gln Leu Ala Pro Glu Xaa Phe Tyr Arg Glu Cys Asp 
                85                  90                  95      


Met Gln Leu Phe Gly Pro Trp Gly Glu Ile Val Ser Pro Ser Leu Ser 
            100                 105                 110         


Pro Ala Xaa Ser Asn Ala Gly Gly Cys Arg Leu Phe Ile Asn Val Ala 
        115                 120                 125             


Pro His Ala Arg Ile Ala Ile His Ala Leu Ala Xaa Asn Met Gly Ala 
    130                 135                 140                 


Gly Xaa Glu Gly Ala Asn Ala Ser Tyr Ile Leu Ile Arg Asp Xaa His 
145                 150                 155                 160 


Ser Leu Arg Xaa Xaa Ala Phe His Gly Gln Gln Val Leu Tyr Trp Glu 
                165                 170                 175     


Ser Glu Ser Ser Gln Ala Glu Met Glu Phe Ser Glu Gly Phe Leu Lys 
            180                 185                 190         


Ala Gln Ala Ser Leu Arg Gly Gln Tyr Trp Xaa Leu Gln Ser Trp Val 
        195                 200                 205             


Pro Glu Met Gln Asp Pro Gln Ser Trp Lys Gly Lys Glu Gly Xaa 
    210                 215                 220             


<210> 1524
<211> 274
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<400> 1524
Met Glu Cys Ala Leu Leu Leu Ala Cys Ala Phe Pro Ala Ala Gly Ser 
1               5                   10                  15      


Gly Pro Pro Arg Gly Leu Ala Gly Leu Gly Arg Val Ala Lys Ala Leu 
            20                  25                  30          


Gln Leu Cys Cys Leu Cys Cys Ala Ser Val Ala Ala Ala Leu Ala Ser 
        35                  40                  45              


Asp Ser Ser Ser Gly Ala Ser Gly Leu Asn Asp Asp Tyr Val Phe Val 
    50                  55                  60                  


Xaa Pro Val Glu Val Asp Ser Ala Gly Ser Tyr Ile Ser His Asp Ile 
65                  70                  75                  80  


Leu His Asn Gly Arg Lys Lys Arg Ser Ala Gln Asn Ala Arg Ser Ser 
                85                  90                  95      


Leu His Tyr Arg Phe Ser Ala Phe Gly Gln Glu Leu His Leu Glu Leu 
            100                 105                 110         


Lys Pro Ser Ala Ile Leu Ser Ser His Phe Ile Val Gln Val Leu Gly 
        115                 120                 125             


Lys Asp Gly Ala Ser Glu Xaa Gln Lys Pro Glu Val Gln Gln Cys Phe 
    130                 135                 140                 


Tyr Gln Gly Phe Ile Arg Asn Asp Ser Ser Ser Ser Val Ala Val Ser 
145                 150                 155                 160 


Xaa Cys Ala Gly Leu Ser Gly Leu Ile Arg Xaa Arg Lys Asn Glu Phe 
                165                 170                 175     


Leu Ile Ser Pro Leu Pro Gln Leu Leu Ala Gln Glu His Asn Tyr Ser 
            180                 185                 190         


Ser Pro Ala Gly His His Pro His Val Leu Tyr Lys Arg Xaa Ala Glu 
        195                 200                 205             


Glu Lys Ile Gln Arg Tyr Arg Gly Tyr Pro Gly Ser Gly Arg Asn Tyr 
    210                 215                 220                 


Pro Gly Tyr Ser Pro Ser His Ile Pro His Ala Ser Gln Ser Arg Glu 
225                 230                 235                 240 


Xaa Glu Tyr His His Arg Arg Leu Gln Lys Gln His Phe Cys Gly Arg 
                245                 250                 255     


Arg Lys Lys Cys Ile Cys Ser Gln Ala Ser His Arg Gly His Leu Ser 
            260                 265                 270         


Lys Val 
        


<210> 1525
<211> 1221
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1138)..(1138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1145)..(1145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1218)..(1218)
<223> Selenocysteine

<400> 1525
Met Glu Cys Ala Leu Leu Leu Ala Cys Ala Phe Pro Ala Ala Gly Ser 
1               5                   10                  15      


Gly Pro Pro Arg Gly Leu Ala Gly Leu Gly Arg Val Ala Lys Ala Leu 
            20                  25                  30          


Gln Leu Cys Cys Leu Cys Cys Ala Ser Val Ala Ala Ala Leu Ala Ser 
        35                  40                  45              


Asp Ser Ser Ser Gly Ala Ser Gly Leu Asn Asp Asp Tyr Val Phe Val 
    50                  55                  60                  


Xaa Pro Val Glu Val Asp Ser Ala Gly Ser Tyr Ile Ser His Asp Ile 
65                  70                  75                  80  


Leu His Asn Gly Arg Lys Lys Arg Ser Ala Gln Asn Ala Arg Ser Ser 
                85                  90                  95      


Leu His Tyr Arg Phe Ser Ala Phe Gly Gln Glu Leu His Leu Glu Leu 
            100                 105                 110         


Lys Pro Ser Ala Ile Leu Ser Ser His Phe Ile Val Gln Val Leu Gly 
        115                 120                 125             


Lys Asp Gly Ala Ser Glu Xaa Gln Lys Pro Glu Val Gln Gln Cys Phe 
    130                 135                 140                 


Tyr Gln Gly Phe Ile Arg Asn Asp Ser Ser Ser Ser Val Ala Val Ser 
145                 150                 155                 160 


Xaa Cys Ala Gly Leu Ser Gly Leu Ile Arg Xaa Arg Lys Asn Glu Phe 
                165                 170                 175     


Leu Ile Ser Pro Leu Pro Gln Leu Leu Ala Gln Glu His Asn Tyr Ser 
            180                 185                 190         


Ser Pro Ala Gly His His Pro His Val Leu Tyr Lys Arg Xaa Ala Glu 
        195                 200                 205             


Glu Lys Ile Gln Arg Tyr Arg Gly Tyr Pro Gly Ser Gly Arg Asn Tyr 
    210                 215                 220                 


Pro Gly Tyr Ser Pro Ser His Ile Pro His Ala Ser Gln Ser Arg Glu 
225                 230                 235                 240 


Xaa Glu Tyr His His Arg Arg Leu Gln Lys Gln His Phe Cys Gly Arg 
                245                 250                 255     


Arg Lys Lys Tyr Ala Pro Lys Pro Pro Xaa Glu Asp Xaa Tyr Leu Arg 
            260                 265                 270         


Phe Asp Glu Tyr Gly Ser Ser Gly Arg Pro Arg Arg Ser Ala Gly Lys 
        275                 280                 285             


Ser Gln Lys Gly Leu Asn Val Glu Xaa Leu Val Val Ala Asp Lys Lys 
    290                 295                 300                 


Met Val Glu Lys His Gly Lys Gly Asn Val Xaa Xaa Tyr Ile Leu Xaa 
305                 310                 315                 320 


Val Met Asn Met Val Ser Gly Leu Phe Lys Asp Gly Xaa Ile Gly Ser 
                325                 330                 335     


Asp Ile Asn Val Val Val Val Ser Leu Ile Leu Leu Glu Gln Glu Pro 
            340                 345                 350         


Gly Gly Leu Leu Ile Asn His His Ala Asp Gln Ser Leu Asn Ser Phe 
        355                 360                 365             


Cys Gln Trp Gln Ser Ala Leu Ile Gly Lys Asn Gly Lys Arg His Asp 
    370                 375                 380                 


His Ala Ile Leu Leu Xaa Gly Phe Asp Ile Cys Ser Trp Lys Asn Glu 
385                 390                 395                 400 


Pro Cys Asp Xaa Leu Gly Phe Ala Pro Ile Ser Gly Met Cys Ser Lys 
                405                 410                 415     


Tyr Arg Ser Cys Xaa Ile Asn Glu Asp Xaa Gly Leu Gly Leu Ala Phe 
            420                 425                 430         


Xaa Ile Ala His Glu Ser Gly His Asn Phe Gly Met Ile His Asp Gly 
        435                 440                 445             


Glu Gly Asn Pro Cys Arg Lys Ala Glu Gly Asn Ile Met Ser Pro Xaa 
    450                 455                 460                 


Leu Xaa Gly Asn Asn Gly Val Phe Ser Trp Ser Ser Cys Ser Arg Gln 
465                 470                 475                 480 


Tyr Leu Lys Lys Phe Leu Ser Xaa Pro Gln Ala Gly Cys Leu Val Asp 
                485                 490                 495     


Glu Pro Lys Gln Ala Gly Gln Tyr Lys Tyr Pro Asp Lys Leu Pro Gly 
            500                 505                 510         


Gln Ile Tyr Asp Ala Asp Xaa Gln Cys Lys Trp Gln Phe Gly Ala Lys 
        515                 520                 525             


Ala Lys Leu Cys Ser Leu Gly Phe Val Lys Asp Ile Cys Lys Ser Leu 
    530                 535                 540                 


Trp Cys His Arg Val Gly His Arg Cys Glu Xaa Lys Phe Met Pro Ala 
545                 550                 555                 560 


Ala Glu Gly Xaa Val Cys Gly Leu Ser Met Trp Cys Arg Gln Gly Gln 
                565                 570                 575     


Cys Val Lys Phe Gly Glu Leu Gly Pro Arg Pro Ile His Gly Gln Trp 
            580                 585                 590         


Ser Ala Trp Ser Lys Trp Ser Glu Cys Ser Arg Xaa Cys Gly Gly Gly 
        595                 600                 605             


Val Lys Phe Gln Glu Arg His Cys Asn Asn Pro Lys Pro Gln Tyr Gly 
    610                 615                 620                 


Gly Leu Phe Cys Pro Gly Ser Ser Arg Ile Tyr Gln Leu Cys Asn Ile 
625                 630                 635                 640 


Asn Pro Cys Asn Glu Asn Ser Leu Asp Phe Arg Ala Gln Gln Cys Ala 
                645                 650                 655     


Glu Tyr Asn Ser Lys Pro Phe Arg Gly Trp Phe Tyr Gln Trp Lys Pro 
            660                 665                 670         


Tyr Xaa Lys Val Glu Glu Glu Asp Arg Cys Lys Leu Tyr Cys Lys Ala 
        675                 680                 685             


Glu Asn Phe Glu Phe Phe Phe Ala Met Ser Gly Lys Val Lys Asp Gly 
    690                 695                 700                 


Xaa Pro Cys Ser Pro Asn Lys Asn Asp Val Cys Ile Asp Gly Val Cys 
705                 710                 715                 720 


Glu Leu Val Gly Cys Asp His Glu Leu Gly Ser Lys Ala Val Ser Asp 
                725                 730                 735     


Ala Cys Gly Val Cys Lys Gly Asp Asn Ser Xaa Cys Lys Phe Tyr Lys 
            740                 745                 750         


Gly Leu Tyr Leu Asn Gln His Lys Ala Asn Glu Tyr Tyr Pro Val Val 
        755                 760                 765             


Leu Ile Pro Ala Gly Ala Arg Ser Ile Glu Ile Gln Glu Leu Gln Val 
    770                 775                 780                 


Ser Ser Ser Tyr Leu Ala Val Arg Ser Leu Ser Gln Lys Tyr Tyr Leu 
785                 790                 795                 800 


Xaa Gly Gly Trp Ser Ile Asp Trp Pro Gly Glu Phe Pro Phe Ala Gly 
                805                 810                 815     


Xaa Xaa Phe Glu Tyr Gln Arg Ser Phe Asn Arg Pro Glu Arg Leu Tyr 
            820                 825                 830         


Ala Pro Gly Pro Xaa Asn Glu Xaa Leu Val Phe Glu Ile Leu Met Gln 
        835                 840                 845             


Gly Lys Asn Pro Gly Ile Ala Trp Lys Tyr Ala Leu Pro Lys Val Met 
    850                 855                 860                 


Asn Gly Xaa Pro Pro Ala Xaa Lys Arg Pro Ala Tyr Xaa Trp Ser Ile 
865                 870                 875                 880 


Val Gln Ser Glu Cys Ser Val Ser Cys Gly Gly Gly Tyr Ile Asn Val 
                885                 890                 895     


Lys Ala Ile Cys Leu Arg Asp Gln Asn Xaa Gln Val Asn Ser Ser Phe 
            900                 905                 910         


Cys Ser Ala Lys Xaa Lys Pro Val Xaa Glu Pro Lys Ile Cys Asn Ala 
        915                 920                 925             


Phe Ser Cys Pro Ala Tyr Trp Met Pro Gly Glu Trp Ser Xaa Cys Ser 
    930                 935                 940                 


Lys Ala Cys Ala Gly Gly Gln Gln Ser Arg Lys Ile Gln Cys Val Gln 
945                 950                 955                 960 


Lys Lys Pro Phe Gln Lys Glu Glu Ala Val Leu His Ser Leu Cys Pro 
                965                 970                 975     


Val Ser Xaa Pro Xaa Gln Val Gln Ala Cys Asn Ser His Ala Cys Pro 
            980                 985                 990         


Pro Gln Trp Ser Leu Gly Pro Trp  Ser Gln Cys Ser Lys  Xaa Cys Gly 
        995                 1000                 1005             


Arg Gly  Val Arg Lys Arg Glu  Leu Leu Cys Lys Gly  Ser Ala Ala 
    1010                 1015                 1020             


Glu Xaa  Leu Pro Glu Ser Gln  Cys Xaa Ser Leu Pro  Arg Pro Glu 
    1025                 1030                 1035             


Leu Gln  Glu Gly Cys Val Leu  Gly Arg Cys Pro Lys  Asn Ser Arg 
    1040                 1045                 1050             


Leu Gln  Trp Val Ala Ser Ser  Trp Ser Glu Cys Ser  Ala Xaa Cys 
    1055                 1060                 1065             


Gly Leu  Gly Val Arg Lys Arg  Glu Met Lys Cys Ser  Glu Lys Gly 
    1070                 1075                 1080             


Phe Gln  Gly Lys Leu Ile Xaa  Phe Pro Glu Arg Arg  Cys Arg Asn 
    1085                 1090                 1095             


Ile Lys  Lys Pro Asn Leu Asp  Leu Glu Glu Xaa Cys  Asn Arg Arg 
    1100                 1105                 1110             


Ala Cys  Pro Ala His Pro Val  Tyr Asn Met Val Ala  Gly Trp Tyr 
    1115                 1120                 1125             


Ser Leu  Pro Trp Gln Gln Cys  Xaa Val Xaa Cys Gly  Gly Gly Val 
    1130                 1135                 1140             


Gln Xaa  Arg Ser Val His Cys  Val Gln Gln Gly Arg  Pro Ser Ser 
    1145                 1150                 1155             


Ser Cys  Leu Leu His Gln Lys  Pro Pro Val Leu Arg  Ala Cys Asn 
    1160                 1165                 1170             


Xaa Asn  Phe Cys Pro Ala Pro  Glu Lys Arg Glu Asp  Pro Ser Cys 
    1175                 1180                 1185             


Val Asp  Phe Phe Asn Trp Cys  His Leu Val Pro Gln  His Gly Val 
    1190                 1195                 1200             


Cys Asn  His Lys Phe Tyr Gly  Lys Gln Cys Cys Lys  Ser Cys Xaa 
    1205                 1210                 1215             


Arg Lys  Ile 
    1220     


<210> 1526
<211> 62
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<400> 1526
Xaa Gln Gly Arg Pro Ser Ser Ser Cys Leu Leu His Gln Lys Pro Pro 
1               5                   10                  15      


Val Leu Arg Ala Cys Asn Xaa Asn Phe Cys Pro Ala Pro Glu Lys Arg 
            20                  25                  30          


Asp Ser Ala Gly Ser Gln Leu Pro Cys Cys Asp Gly Pro Gln Ala Val 
        35                  40                  45              


His Glu Glu Gly Leu Arg Phe Pro Asp Asn His Trp Ala Met 
    50                  55                  60          


<210> 1527
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<400> 1527
Xaa Val Asp Ser Ala Gly Ser Tyr Ile Ser His Asp Ile Leu His Asn 
1               5                   10                  15      


Gly Arg Lys Lys Arg Ser Ala Gln Asn Ala Arg Ser Ser Leu His Tyr 
            20                  25                  30          


Arg Phe Ser Ala Phe Gly Gln Glu Leu His Leu Glu Leu Lys Pro Ser 
        35                  40                  45              


Ala Ile Leu Ser Ser His Phe Ile Val Gln Val Leu Gly Lys Asp Gly 
    50                  55                  60                  


Ala Ser Glu Xaa Gln Lys Pro Glu Val Gln Gln Cys Phe Tyr Gln Gly 
65                  70                  75                  80  


Phe Ile Arg Asn Asp Ser Ser Ser Ser Val Ala Val Ser Xaa Cys Ala 
                85                  90                  95      


Gly Leu Leu Leu Ala Gln Glu His Asn Tyr Ser Ser Pro Ala Gly His 
            100                 105                 110         


His Pro His Val Leu Tyr Lys Arg Xaa Ala Glu Glu Lys Ile Gln Arg 
        115                 120                 125             


Tyr Arg Gly Tyr Pro Gly Ser Gly Arg Asn Tyr Pro Gly Tyr Ser Pro 
    130                 135                 140                 


Ser His Ile Pro His Ala Ser Gln Ser Arg Glu Xaa Glu Tyr His His 
145                 150                 155                 160 


Arg Arg Leu Gln Lys Gln His Phe Cys Gly Arg Arg Lys Lys Cys Ile 
                165                 170                 175     


Cys Ser Gln Ala Ser His Arg Gly His Leu 
            180                 185     


<210> 1528
<211> 1504
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1206)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1440)..(1440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1466)..(1466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1479)..(1479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1482)..(1482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1493)..(1493)
<223> Selenocysteine

<400> 1528
Met Trp Val Ala Lys Trp Leu Xaa Gly Leu Leu Tyr His Leu Ser Leu 
1               5                   10                  15      


Phe Ile Xaa Arg Ser Trp Glu Val Asp Phe His Pro Arg Gln Glu Ala 
            20                  25                  30          


Leu Val Arg Xaa Leu Xaa Ser Tyr Glu Val Val Ile Pro Glu Arg Val 
        35                  40                  45              


Asn Glu Phe Gly Glu Val Phe Pro Gln Ser His His Phe Ser Arg Gln 
    50                  55                  60                  


Lys Arg Ser Ser Glu Ala Leu Glu Pro Met Pro Phe Arg Xaa His Tyr 
65                  70                  75                  80  


Arg Phe Xaa Ala Tyr Gly Gln Leu Phe Gln Leu Asn Leu Xaa Ala Asp 
                85                  90                  95      


Ala Ser Phe Leu Ala Ala Gly Tyr Xaa Glu Val His Leu Gly Xaa Pro 
            100                 105                 110         


Glu Arg Gly Ala Trp Glu Ser Asp Ala Gly Pro Ser Asp Leu Arg His 
        115                 120                 125             


Cys Phe Tyr Arg Gly Gln Val Asn Ser Gln Glu Asp Tyr Lys Ala Val 
    130                 135                 140                 


Val Ser Leu Cys Gly Gly Leu Xaa Gly Xaa Phe Lys Gly Gln Asn Gly 
145                 150                 155                 160 


Glu Tyr Phe Leu Glu Pro Ile Met Lys Ala Asp Gly Asn Glu Tyr Glu 
                165                 170                 175     


Asp Gly His Asn Lys Pro His Leu Ile Tyr Arg Gln Asp Leu Asn Asn 
            180                 185                 190         


Ser Phe Leu Gln Xaa Leu Lys Tyr Cys Ser Val Ser Glu Ser Gln Ile 
        195                 200                 205             


Lys Glu Xaa Ser Leu Pro Phe His Xaa Tyr Ser Asn Met Asn Glu Asp 
    210                 215                 220                 


Leu Asn Val Met Lys Glu Arg Val Leu Gly His Xaa Ser Lys Asn Val 
225                 230                 235                 240 


Pro Leu Lys Asp Glu Arg Arg His Ser Arg Lys Lys Arg Leu Ile Ser 
                245                 250                 255     


Tyr Pro Arg Tyr Ile Glu Ile Met Val Xaa Ala Asp Ala Lys Val Val 
            260                 265                 270         


Ser Ala His Gly Ser Asn Leu Gln Asn Tyr Ile Leu Xaa Leu Met Ser 
        275                 280                 285             


Ile Val Ala Xaa Ile Tyr Lys Asp Pro Ser Ile Gly Asn Leu Ile His 
    290                 295                 300                 


Ile Val Val Val Lys Leu Val Met Ile His Arg Glu Glu Glu Gly Pro 
305                 310                 315                 320 


Val Ile Asn Phe Asp Gly Ala Xaa Xaa Leu Lys Asn Phe Cys Ser Trp 
                325                 330                 335     


Gln Gln Xaa Gln Asn Asp Leu Asp Asp Val His Pro Ser His His Asp 
            340                 345                 350         


Xaa Ala Val Leu Ile Xaa Arg Glu Asp Ile Cys Ser Ser Lys Glu Lys 
        355                 360                 365             


Cys Asn Met Leu Gly Leu Ser Tyr Leu Gly Xaa Ile Cys Asp Pro Leu 
    370                 375                 380                 


Gln Ser Cys Phe Ile Asn Glu Glu Lys Gly Leu Ile Ser Ala Phe Xaa 
385                 390                 395                 400 


Ile Ala His Glu Leu Gly His Xaa Leu Gly Val Gln His Asp Asp Asn 
                405                 410                 415     


Pro Arg Cys Lys Glu Met Lys Val Xaa Lys Tyr His Val Met Ala Pro 
            420                 425                 430         


Ala Leu Ser Phe His Met Ser Pro Trp Ser Trp Ser Asn Cys Ser Arg 
        435                 440                 445             


Lys Tyr Val Xaa Glu Phe Leu Asp Xaa Gly Tyr Gly Glu Cys Leu Leu 
    450                 455                 460                 


Asp Lys Pro Asp Glu Glu Ile Tyr Asn Leu Pro Ser Glu Leu Pro Gly 
465                 470                 475                 480 


Ser Arg Tyr Asp Gly Asn Lys Gln Cys Glu Leu Ala Phe Gly Pro Gly 
                485                 490                 495     


Ser Gln Met Cys Pro His Ile Asn Ile Cys Met His Leu Trp Cys Xaa 
            500                 505                 510         


Ser Xaa Glu Lys Leu His Lys Gly Cys Phe Xaa Gln His Val Pro Pro 
        515                 520                 525             


Ala Asp Gly Xaa Asp Cys Gly Pro Gly Met His Cys Arg His Gly Leu 
    530                 535                 540                 


Cys Val Asn Lys Glu Xaa Glu Xaa Arg Pro Val Asn Gly Glu Trp Gly 
545                 550                 555                 560 


Pro Trp Glu Pro Tyr Ser Ser Cys Ser Arg Xaa Cys Gly Gly Gly Ile 
                565                 570                 575     


Glu Ser Ala Xaa Arg Arg Cys Asn Arg Pro Glu Pro Arg Asn Gly Gly 
            580                 585                 590         


Asn Tyr Cys Val Gly Arg Arg Met Lys Phe Arg Ser Cys Asn Xaa Asp 
        595                 600                 605             


Ser Cys Pro Lys Gly Xaa Gln Asp Phe Arg Glu Lys Gln Cys Ser Asp 
    610                 615                 620                 


Phe Asn Gly Lys His Leu Asp Ile Ser Gly Ile Pro Ser Asn Val Arg 
625                 630                 635                 640 


Trp Leu Pro Arg Tyr Ser Gly Ile Gly Xaa Lys Asp Arg Cys Lys Leu 
                645                 650                 655     


Tyr Cys Gln Val Ala Gly Xaa Asn Tyr Phe Tyr Leu Leu Lys Asp Met 
            660                 665                 670         


Val Glu Asp Gly Xaa Pro Cys Gly Xaa Glu Xaa His Asp Ile Cys Val 
        675                 680                 685             


Gln Gly Gln Cys Met Ala Ala Gly Cys Asp His Val Leu Asn Ser Ser 
    690                 695                 700                 


Ala Lys Ile Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys 
705                 710                 715                 720 


Lys Xaa Ile Xaa Gly Val Phe Asn Ser Ser His Tyr Gly Tyr Asn Val 
                725                 730                 735     


Val Val Lys Ile Pro Ala Gly Ala Xaa Asn Val Asp Ile Arg Gln Tyr 
            740                 745                 750         


Ser Tyr Ser Gly Gln Pro Asp Asp Ser Tyr Leu Ala Leu Ser Asp Ala 
        755                 760                 765             


Glu Gly Asn Phe Leu Phe Asn Gly Asn Phe Leu Leu Ser Xaa Ser Lys 
    770                 775                 780                 


Lys Glu Ile Asn Val Gln Gly Xaa Arg Xaa Val Ile Glu Tyr Ser Gly 
785                 790                 795                 800 


Ser Asn Asn Ala Val Glu Arg Ile Asn Ser Xaa Asn Arg Gln Glu Lys 
                805                 810                 815     


Glu Leu Ile Leu Gln Val Leu Cys Val Gly Asn Leu Tyr Asn Pro Asp 
            820                 825                 830         


Val His Tyr Ser Phe Asn Ile Pro Leu Glu Glu Arg Ser Asp Met Phe 
        835                 840                 845             


Xaa Trp Asp Pro Tyr Gly Pro Trp Glu Gly Cys Xaa Lys Met Cys Gln 
    850                 855                 860                 


Gly Leu Gln Arg Arg Asn Ile Xaa Cys Ile His Lys Ser Asp His Ser 
865                 870                 875                 880 


Val Val Ser Asp Lys Glu Cys Asp His Leu Pro Leu Pro Ser Phe Val 
                885                 890                 895     


Xaa Gln Ser Cys Asn Xaa Asp Cys Glu Leu Arg Trp His Val Ile Gly 
            900                 905                 910         


Lys Ser Glu Cys Ser Ser Gln Cys Gly Gln Gly Tyr Arg Xaa Leu Asp 
        915                 920                 925             


Ile His Cys Met Lys Tyr Ser Ile His Glu Gly Gln Xaa Val Gln Val 
    930                 935                 940                 


Asp Asp His Tyr Cys Gly Asp Gln Leu Lys Pro Pro Xaa Gln Glu Leu 
945                 950                 955                 960 


Cys His Gly Asn Cys Val Phe Xaa Arg Trp His Tyr Ser Glu Trp Ser 
                965                 970                 975     


Gln Cys Ser Arg Ser Cys Gly Gly Gly Glu Arg Ser Arg Glu Ser Tyr 
            980                 985                 990         


Cys Met Asn Asn Phe Gly His Arg  Leu Ala Asp Asn Glu  Cys Gln Glu 
        995                 1000                 1005             


Leu Ser  Arg Val Xaa Arg Glu  Asn Cys Asn Glu Phe  Ser Cys Pro 
    1010                 1015                 1020             


Ser Trp  Ala Ala Ser Glu Trp  Ser Glu Cys Leu Val  Xaa Cys Gly 
    1025                 1030                 1035             


Lys Gly  Xaa Lys Gln Arg Gln  Val Trp Cys Gln Leu  Asn Val Asp 
    1040                 1045                 1050             


His Leu  Ser Asp Gly Phe Cys  Asn Ser Ser Xaa Lys  Pro Glu Ser 
    1055                 1060                 1065             


Leu Ser  Pro Cys Glu Leu His  Xaa Cys Ala Ser Trp  Gln Val Gly 
    1070                 1075                 1080             


Pro Trp  Gly Pro Cys Xaa Xaa  Xaa Cys Gly His Gly  Tyr Gln Met 
    1085                 1090                 1095             


Arg Asp  Val Lys Cys Val Asn  Glu Leu Ala Ser Ala  Val Leu Glu 
    1100                 1105                 1110             


Asp Xaa  Glu Cys His Glu Ala  Ser Arg Pro Ser Asp  Arg Gln Ser 
    1115                 1120                 1125             


Cys Val  Leu Xaa Pro Cys Ser  Phe Ile Ser Lys Leu  Glu Xaa Ala 
    1130                 1135                 1140             


Leu Leu  Pro Xaa Val Leu Ile  Lys Lys Met Ala Gln  Trp Arg His 
    1145                 1150                 1155             


Gly Ser  Trp Xaa Pro Cys Ser  Val Ser Cys Gly Arg  Gly Xaa Gln 
    1160                 1165                 1170             


Ala Arg  Tyr Val Ser Cys Arg  Asp Ala Leu Asp Arg  Ile Ala Asp 
    1175                 1180                 1185             


Glu Ser  Tyr Cys Ala His Leu  Pro Arg Pro Ala Glu  Ile Trp Asp 
    1190                 1195                 1200             


Cys Phe  Xaa Pro Cys Gly Glu  Trp Gln Ala Gly Asp  Trp Ser Pro 
    1205                 1210                 1215             


Cys Ser  Ala Ser Cys Gly His  Gly Lys Xaa Xaa Arg  Gln Val Leu 
    1220                 1225                 1230             


Cys Met  Asn Tyr His Gln Pro  Ile Asp Glu Asn Tyr  Cys Asp Pro 
    1235                 1240                 1245             


Glu Val  Arg Pro Leu Met Glu  Gln Glu Cys Ser Leu  Ala Ala Cys 
    1250                 1255                 1260             


Pro Pro  Ala His Ser His Phe  Pro Ser Ser Pro Val  Gln Pro Ser 
    1265                 1270                 1275             


Tyr Tyr  Leu Ser Xaa Asn Leu  Pro Leu Xaa Gln Lys  Leu Glu Asp 
    1280                 1285                 1290             


Asn Glu  Asn Gln Val Val His  Pro Ser Val Arg Gly  Asn Gln Trp 
    1295                 1300                 1305             


Arg Xaa  Gly Pro Trp Gly Ser  Cys Ser Ser Ser Cys  Ser Gly Gly 
    1310                 1315                 1320             


Leu Gln  His Arg Ala Val Val  Cys Gln Asp Glu Asn  Gly Gln Ser 
    1325                 1330                 1335             


Ala Ser  Tyr Cys Asp Ala Ala  Ser Lys Pro Pro Glu  Leu Gln Gln 
    1340                 1345                 1350             


Cys Gly  Pro Gly Pro Cys Pro  Gln Trp Asn Tyr Gly  Asn Trp Gly 
    1355                 1360                 1365             


Glu Cys  Ser Gln Xaa Cys Gly  Gly Gly Ile Lys Ser  Arg Leu Val 
    1370                 1375                 1380             


Ile Cys  Gln Phe Pro Asn Gly  Gln Ile Leu Glu Asp  His Asn Cys 
    1385                 1390                 1395             


Glu Ile  Val Asn Lys Pro Pro  Ser Val Ile Gln Cys  His Met His 
    1400                 1405                 1410             


Ala Cys  Pro Ala Asp Val Ser  Trp His Gln Glu Pro  Trp Xaa Ser 
    1415                 1420                 1425             


Glu Asp  Leu Lys Val Lys Leu  Leu Pro Gln Arg Xaa  Ile Ile Leu 
    1430                 1435                 1440             


Trp Glu  Leu Met Lys Asn Ile  Phe Cys His Gly Lys  His Ser His 
    1445                 1450                 1455             


Met Tyr  Leu Ile Asn Val Val  Xaa Asp His Leu Leu  Tyr Pro Arg 
    1460                 1465                 1470             


His Cys  Asp Pro Glu Xaa Ile  Glu Xaa Tyr Phe Leu  Ser Leu Trp 
    1475                 1480                 1485             


Ser Leu  Gln Phe Xaa Trp Gly  Asp Leu Lys Tyr Tyr  Lys Asn Ser 
    1490                 1495                 1500             


Leu 
    


<210> 1529
<211> 1910
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1206)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1465)..(1465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1488)..(1488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1517)..(1517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1559)..(1559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1575)..(1575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1579)..(1579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1613)..(1613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1616)..(1616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1669)..(1669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1683)..(1683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1713)..(1714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1756)..(1756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1800)..(1800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1810)..(1810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1816)..(1817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1824)..(1824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1834)..(1834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1856)..(1856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1863)..(1863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1868)..(1868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1873)..(1873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1884)..(1884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1902)..(1903)
<223> Selenocysteine

<400> 1529
Met Trp Val Ala Lys Trp Leu Xaa Gly Leu Leu Tyr His Leu Ser Leu 
1               5                   10                  15      


Phe Ile Xaa Arg Ser Trp Glu Val Asp Phe His Pro Arg Gln Glu Ala 
            20                  25                  30          


Leu Val Arg Xaa Leu Xaa Ser Tyr Glu Val Val Ile Pro Glu Arg Val 
        35                  40                  45              


Asn Glu Phe Gly Glu Val Phe Pro Gln Ser His His Phe Ser Arg Gln 
    50                  55                  60                  


Lys Arg Ser Ser Glu Ala Leu Glu Pro Met Pro Phe Arg Xaa His Tyr 
65                  70                  75                  80  


Arg Phe Xaa Ala Tyr Gly Gln Leu Phe Gln Leu Asn Leu Xaa Ala Asp 
                85                  90                  95      


Ala Ser Phe Leu Ala Ala Gly Tyr Xaa Glu Val His Leu Gly Xaa Pro 
            100                 105                 110         


Glu Arg Gly Ala Trp Glu Ser Asp Ala Gly Pro Ser Asp Leu Arg His 
        115                 120                 125             


Cys Phe Tyr Arg Gly Gln Val Asn Ser Gln Glu Asp Tyr Lys Ala Val 
    130                 135                 140                 


Val Ser Leu Cys Gly Gly Leu Xaa Gly Xaa Phe Lys Gly Gln Asn Gly 
145                 150                 155                 160 


Glu Tyr Phe Leu Glu Pro Ile Met Lys Ala Asp Gly Asn Glu Tyr Glu 
                165                 170                 175     


Asp Gly His Asn Lys Pro His Leu Ile Tyr Arg Gln Asp Leu Asn Asn 
            180                 185                 190         


Ser Phe Leu Gln Xaa Leu Lys Tyr Cys Ser Val Ser Glu Ser Gln Ile 
        195                 200                 205             


Lys Glu Xaa Ser Leu Pro Phe His Xaa Tyr Ser Asn Met Asn Glu Asp 
    210                 215                 220                 


Leu Asn Val Met Lys Glu Arg Val Leu Gly His Xaa Ser Lys Asn Val 
225                 230                 235                 240 


Pro Leu Lys Asp Glu Arg Arg His Ser Arg Lys Lys Arg Leu Ile Ser 
                245                 250                 255     


Tyr Pro Arg Tyr Ile Glu Ile Met Val Xaa Ala Asp Ala Lys Val Val 
            260                 265                 270         


Ser Ala His Gly Ser Asn Leu Gln Asn Tyr Ile Leu Xaa Leu Met Ser 
        275                 280                 285             


Ile Val Ala Xaa Ile Tyr Lys Asp Pro Ser Ile Gly Asn Leu Ile His 
    290                 295                 300                 


Ile Val Val Val Lys Leu Val Met Ile His Arg Glu Glu Glu Gly Pro 
305                 310                 315                 320 


Val Ile Asn Phe Asp Gly Ala Xaa Xaa Leu Lys Asn Phe Cys Ser Trp 
                325                 330                 335     


Gln Gln Xaa Gln Asn Asp Leu Asp Asp Val His Pro Ser His His Asp 
            340                 345                 350         


Xaa Ala Val Leu Ile Xaa Arg Glu Asp Ile Cys Ser Ser Lys Glu Lys 
        355                 360                 365             


Cys Asn Met Leu Gly Leu Ser Tyr Leu Gly Xaa Ile Cys Asp Pro Leu 
    370                 375                 380                 


Gln Ser Cys Phe Ile Asn Glu Glu Lys Gly Leu Ile Ser Ala Phe Xaa 
385                 390                 395                 400 


Ile Ala His Glu Leu Gly His Xaa Leu Gly Val Gln His Asp Asp Asn 
                405                 410                 415     


Pro Arg Cys Lys Glu Met Lys Val Xaa Lys Tyr His Val Met Ala Pro 
            420                 425                 430         


Ala Leu Ser Phe His Met Ser Pro Trp Ser Trp Ser Asn Cys Ser Arg 
        435                 440                 445             


Lys Tyr Val Xaa Glu Phe Leu Asp Xaa Gly Tyr Gly Glu Cys Leu Leu 
    450                 455                 460                 


Asp Lys Pro Asp Glu Glu Ile Tyr Asn Leu Pro Ser Glu Leu Pro Gly 
465                 470                 475                 480 


Ser Arg Tyr Asp Gly Asn Lys Gln Cys Glu Leu Ala Phe Gly Pro Gly 
                485                 490                 495     


Ser Gln Met Cys Pro His Ile Asn Ile Cys Met His Leu Trp Cys Xaa 
            500                 505                 510         


Ser Xaa Glu Lys Leu His Lys Gly Cys Phe Xaa Gln His Val Pro Pro 
        515                 520                 525             


Ala Asp Gly Xaa Asp Cys Gly Pro Gly Met His Cys Arg His Gly Leu 
    530                 535                 540                 


Cys Val Asn Lys Glu Xaa Glu Xaa Arg Pro Val Asn Gly Glu Trp Gly 
545                 550                 555                 560 


Pro Trp Glu Pro Tyr Ser Ser Cys Ser Arg Xaa Cys Gly Gly Gly Ile 
                565                 570                 575     


Glu Ser Ala Xaa Arg Arg Cys Asn Arg Pro Glu Pro Arg Asn Gly Gly 
            580                 585                 590         


Asn Tyr Cys Val Gly Arg Arg Met Lys Phe Arg Ser Cys Asn Xaa Asp 
        595                 600                 605             


Ser Cys Pro Lys Gly Xaa Gln Asp Phe Arg Glu Lys Gln Cys Ser Asp 
    610                 615                 620                 


Phe Asn Gly Lys His Leu Asp Ile Ser Gly Ile Pro Ser Asn Val Arg 
625                 630                 635                 640 


Trp Leu Pro Arg Tyr Ser Gly Ile Gly Xaa Lys Asp Arg Cys Lys Leu 
                645                 650                 655     


Tyr Cys Gln Val Ala Gly Xaa Asn Tyr Phe Tyr Leu Leu Lys Asp Met 
            660                 665                 670         


Val Glu Asp Gly Xaa Pro Cys Gly Xaa Glu Xaa His Asp Ile Cys Val 
        675                 680                 685             


Gln Gly Gln Cys Met Ala Ala Gly Cys Asp His Val Leu Asn Ser Ser 
    690                 695                 700                 


Ala Lys Ile Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys 
705                 710                 715                 720 


Lys Xaa Ile Xaa Gly Val Phe Asn Ser Ser His Tyr Gly Tyr Asn Val 
                725                 730                 735     


Val Val Lys Ile Pro Ala Gly Ala Xaa Asn Val Asp Ile Arg Gln Tyr 
            740                 745                 750         


Ser Tyr Ser Gly Gln Pro Asp Asp Ser Tyr Leu Ala Leu Ser Asp Ala 
        755                 760                 765             


Glu Gly Asn Phe Leu Phe Asn Gly Asn Phe Leu Leu Ser Xaa Ser Lys 
    770                 775                 780                 


Lys Glu Ile Asn Val Gln Gly Xaa Arg Xaa Val Ile Glu Tyr Ser Gly 
785                 790                 795                 800 


Ser Asn Asn Ala Val Glu Arg Ile Asn Ser Xaa Asn Arg Gln Glu Lys 
                805                 810                 815     


Glu Leu Ile Leu Gln Val Leu Cys Val Gly Asn Leu Tyr Asn Pro Asp 
            820                 825                 830         


Val His Tyr Ser Phe Asn Ile Pro Leu Glu Glu Arg Ser Asp Met Phe 
        835                 840                 845             


Xaa Trp Asp Pro Tyr Gly Pro Trp Glu Gly Cys Xaa Lys Met Cys Gln 
    850                 855                 860                 


Gly Leu Gln Arg Arg Asn Ile Xaa Cys Ile His Lys Ser Asp His Ser 
865                 870                 875                 880 


Val Val Ser Asp Lys Glu Cys Asp His Leu Pro Leu Pro Ser Phe Val 
                885                 890                 895     


Xaa Gln Ser Cys Asn Xaa Asp Cys Glu Leu Arg Trp His Val Ile Gly 
            900                 905                 910         


Lys Ser Glu Cys Ser Ser Gln Cys Gly Gln Gly Tyr Arg Xaa Leu Asp 
        915                 920                 925             


Ile His Cys Met Lys Tyr Ser Ile His Glu Gly Gln Xaa Val Gln Val 
    930                 935                 940                 


Asp Asp His Tyr Cys Gly Asp Gln Leu Lys Pro Pro Xaa Gln Glu Leu 
945                 950                 955                 960 


Cys His Gly Asn Cys Val Phe Xaa Arg Trp His Tyr Ser Glu Trp Ser 
                965                 970                 975     


Gln Cys Ser Arg Ser Cys Gly Gly Gly Glu Arg Ser Arg Glu Ser Tyr 
            980                 985                 990         


Cys Met Asn Asn Phe Gly His Arg  Leu Ala Asp Asn Glu  Cys Gln Glu 
        995                 1000                 1005             


Leu Ser  Arg Val Xaa Arg Glu  Asn Cys Asn Glu Phe  Ser Cys Pro 
    1010                 1015                 1020             


Ser Trp  Ala Ala Ser Glu Trp  Ser Glu Cys Leu Val  Xaa Cys Gly 
    1025                 1030                 1035             


Lys Gly  Xaa Lys Gln Arg Gln  Val Trp Cys Gln Leu  Asn Val Asp 
    1040                 1045                 1050             


His Leu  Ser Asp Gly Phe Cys  Asn Ser Ser Xaa Lys  Pro Glu Ser 
    1055                 1060                 1065             


Leu Ser  Pro Cys Glu Leu His  Xaa Cys Ala Ser Trp  Gln Val Gly 
    1070                 1075                 1080             


Pro Trp  Gly Pro Cys Xaa Xaa  Xaa Cys Gly His Gly  Tyr Gln Met 
    1085                 1090                 1095             


Arg Asp  Val Lys Cys Val Asn  Glu Leu Ala Ser Ala  Val Leu Glu 
    1100                 1105                 1110             


Asp Xaa  Glu Cys His Glu Ala  Ser Arg Pro Ser Asp  Arg Gln Ser 
    1115                 1120                 1125             


Cys Val  Leu Xaa Pro Cys Ser  Phe Ile Ser Lys Leu  Glu Xaa Ala 
    1130                 1135                 1140             


Leu Leu  Pro Xaa Val Leu Ile  Lys Lys Met Ala Gln  Trp Arg His 
    1145                 1150                 1155             


Gly Ser  Trp Xaa Pro Cys Ser  Val Ser Cys Gly Arg  Gly Xaa Gln 
    1160                 1165                 1170             


Ala Arg  Tyr Val Ser Cys Arg  Asp Ala Leu Asp Arg  Ile Ala Asp 
    1175                 1180                 1185             


Glu Ser  Tyr Cys Ala His Leu  Pro Arg Pro Ala Glu  Ile Trp Asp 
    1190                 1195                 1200             


Cys Phe  Xaa Pro Cys Gly Glu  Trp Gln Ala Gly Asp  Trp Ser Pro 
    1205                 1210                 1215             


Cys Ser  Ala Ser Cys Gly His  Gly Lys Xaa Xaa Arg  Gln Val Leu 
    1220                 1225                 1230             


Cys Met  Asn Tyr His Gln Pro  Ile Asp Glu Asn Tyr  Cys Asp Pro 
    1235                 1240                 1245             


Glu Val  Arg Pro Leu Met Glu  Gln Glu Cys Ser Leu  Ala Ala Cys 
    1250                 1255                 1260             


Pro Pro  Ala His Ser His Phe  Pro Ser Ser Pro Val  Gln Pro Ser 
    1265                 1270                 1275             


Tyr Tyr  Leu Ser Xaa Asn Leu  Pro Leu Xaa Gln Lys  Leu Glu Asp 
    1280                 1285                 1290             


Asn Glu  Asn Gln Val Val His  Pro Ser Val Arg Gly  Asn Gln Trp 
    1295                 1300                 1305             


Arg Xaa  Gly Pro Trp Gly Ser  Cys Ser Ser Ser Cys  Ser Gly Gly 
    1310                 1315                 1320             


Leu Gln  His Arg Ala Val Val  Cys Gln Asp Glu Asn  Gly Gln Ser 
    1325                 1330                 1335             


Ala Ser  Tyr Cys Asp Ala Ala  Ser Lys Pro Pro Glu  Leu Gln Gln 
    1340                 1345                 1350             


Cys Gly  Pro Gly Pro Cys Pro  Gln Trp Asn Tyr Gly  Asn Trp Gly 
    1355                 1360                 1365             


Glu Cys  Ser Gln Xaa Cys Gly  Gly Gly Ile Lys Ser  Arg Leu Val 
    1370                 1375                 1380             


Ile Cys  Gln Phe Pro Asn Gly  Gln Ile Leu Glu Asp  His Asn Cys 
    1385                 1390                 1395             


Glu Ile  Val Asn Lys Pro Pro  Ser Val Ile Gln Cys  His Met His 
    1400                 1405                 1410             


Ala Cys  Pro Ala Asp Val Ser  Trp His Gln Glu Pro  Trp Xaa Ser 
    1415                 1420                 1425             


Cys Ser  Ala Ser Cys Gly Lys  Gly Arg Lys Tyr Arg  Glu Val Phe 
    1430                 1435                 1440             


Cys Ile  Asp Gln Phe Gln Arg  Lys Leu Glu Asp Xaa  Asn Cys Ser 
    1445                 1450                 1455             


Gln Val  Gln Lys Pro Pro Xaa  His Lys Ala Cys Arg  Ser Val Arg 
    1460                 1465                 1470             


Cys Pro  Ser Trp Lys Ala Asn  Ser Trp Asn Glu Cys  Ser Val Xaa 
    1475                 1480                 1485             


Cys Gly  Ser Gly Val Gln Gln  Arg Asp Val Tyr Cys  Arg Leu Lys 
    1490                 1495                 1500             


Gly Val  Gly Gln Val Val Glu  Glu Met Cys Asp Gln  Ser Xaa Arg 
    1505                 1510                 1515             


Pro Cys  Ser Gln Arg Arg Cys  Trp Ser Gln Asp Cys  Val Gln His 
    1520                 1525                 1530             


Lys Gly  Met Glu Arg Gly Arg  Leu Asn Cys Ser Xaa  Ser Cys Glu 
    1535                 1540                 1545             


Arg Lys  Asp Ser His Gln Arg  Met Glu Cys Xaa Asp  Asn Gln Ile 
    1550                 1555                 1560             


Arg Gln  Val Asn Glu Ile Val  Tyr Asn Ser Ser Xaa  Ile Ser Leu 
    1565                 1570                 1575             


Xaa Ser  Lys Asn Cys Arg Asn  Pro Pro Cys Asn Tyr  Ile Val Val 
    1580                 1585                 1590             


Xaa Ala  Asp Ser Ser Gln Cys  Ala Asn Asn Cys Gly  Phe Ser Tyr 
    1595                 1600                 1605             


Arg Gln  Arg Ile Xaa Tyr Cys  Xaa Glu Ile Pro Ser  Xaa Lys Lys 
    1610                 1615                 1620             


His Lys  Leu His Arg Leu Arg  Pro Ile Val Tyr Gln  Glu Cys Pro 
    1625                 1630                 1635             


Val Val  Pro Ser Ser Gln Val  Tyr Gln Cys Ile Asn  Ser Cys Leu 
    1640                 1645                 1650             


His Leu  Ala Xaa Trp Lys Val  Gly Lys Trp Ser Lys  Cys Ser Val 
    1655                 1660                 1665             


Xaa Cys  Gly Ile Gly Ile Met  Lys Arg Gln Val Lys  Cys Ile Xaa 
    1670                 1675                 1680             


Lys His  Gly Leu Ser Ser Asp  Leu Cys Leu Asn His  Leu Lys Pro 
    1685                 1690                 1695             


Gly Ala  Gln Lys Lys Cys Tyr  Ala Asn Asp Cys Lys  Ser Phe Xaa 
    1700                 1705                 1710             


Xaa Cys  Lys Glu Ile Gln Val  Lys Asn His Ile Arg  Lys Asp Gly 
    1715                 1720                 1725             


Asp Tyr  Tyr Leu Asn Ile Lys  Gly Arg Ile Ile Lys  Ile Tyr Cys 
    1730                 1735                 1740             


Ala Asp  Met Tyr Leu Glu Asn  Pro Lys Glu Tyr Leu  Xaa Leu Val 
    1745                 1750                 1755             


Gln Gly  Glu Glu Asn Phe Ser  Glu Val Tyr Gly Phe  Arg Leu Lys 
    1760                 1765                 1770             


Asn Pro  Tyr Gln Cys Pro Phe  Asn Gly Ser Arg Arg  Glu Asp Cys 
    1775                 1780                 1785             


Glu Cys  Asp Asn Gly His Leu  Ala Ala Gly Tyr Xaa  Val Phe Ser 
    1790                 1795                 1800             


Lys Ile  Arg Ile Asp Leu Xaa  Ser Met Gln Ile Lys  Xaa Xaa Asp 
    1805                 1810                 1815             


Leu Leu  Phe Ser Lys Xaa Ile  Phe Gly Asn Ala Val  Pro Phe Ala 
    1820                 1825                 1830             


Xaa Ala  Gly Asp Cys Tyr Ser  Ala Phe Arg Cys Pro  Gln Gly Gln 
    1835                 1840                 1845             


Phe Ser  Ile Asn Leu Ser Gly  Xaa Gly Met Lys Ile  Ser Ser Xaa 
    1850                 1855                 1860             


Ala Lys  Trp Leu Xaa Gln Gly  Ser Tyr Xaa Ser Val  Ser Ile Arg 
    1865                 1870                 1875             


Arg Ser  Glu Asp Gly Xaa Arg  Phe Phe Gly Lys Cys  Gly Gly Tyr 
    1880                 1885                 1890             


Cys Gly  Lys Cys Leu Pro His  Met Xaa Xaa Gly Leu  Pro Ile Gln 
    1895                 1900                 1905             


Val Ile  
    1910 


<210> 1530
<211> 1504
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1206)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1440)..(1440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1466)..(1466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1479)..(1479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1482)..(1482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1493)..(1493)
<223> Selenocysteine

<400> 1530
Met Trp Val Ala Lys Trp Leu Xaa Gly Leu Leu Tyr His Leu Ser Leu 
1               5                   10                  15      


Phe Ile Xaa Arg Ser Trp Glu Val Asp Phe His Pro Arg Gln Glu Ala 
            20                  25                  30          


Leu Val Arg Xaa Leu Xaa Ser Tyr Glu Val Val Ile Pro Glu Arg Val 
        35                  40                  45              


Asn Glu Phe Gly Glu Val Phe Pro Gln Ser His His Phe Ser Arg Gln 
    50                  55                  60                  


Lys Arg Ser Ser Glu Ala Leu Glu Pro Met Pro Phe Arg Xaa His Tyr 
65                  70                  75                  80  


Arg Phe Xaa Ala Tyr Gly Gln Leu Phe Gln Leu Asn Leu Xaa Ala Asp 
                85                  90                  95      


Ala Ser Phe Leu Ala Ala Gly Tyr Xaa Glu Val His Leu Gly Xaa Pro 
            100                 105                 110         


Glu Arg Gly Ala Trp Glu Ser Asp Ala Gly Pro Ser Asp Leu Arg His 
        115                 120                 125             


Cys Phe Tyr Arg Gly Gln Val Asn Ser Gln Glu Asp Tyr Lys Ala Val 
    130                 135                 140                 


Val Ser Leu Cys Gly Gly Leu Val Gly Xaa Phe Lys Gly Gln Asn Gly 
145                 150                 155                 160 


Glu Tyr Phe Leu Glu Pro Ile Met Lys Ala Asp Gly Asn Glu Tyr Glu 
                165                 170                 175     


Asp Gly His Asn Lys Pro His Leu Ile Tyr Arg Gln Asp Leu Asn Asn 
            180                 185                 190         


Ser Phe Leu Gln Xaa Leu Lys Tyr Cys Ser Val Ser Glu Ser Gln Ile 
        195                 200                 205             


Lys Glu Xaa Ser Leu Pro Phe His Xaa Tyr Ser Asn Met Asn Glu Asp 
    210                 215                 220                 


Leu Asn Val Met Lys Glu Arg Val Leu Gly His Xaa Ser Lys Asn Val 
225                 230                 235                 240 


Pro Leu Lys Asp Glu Arg Arg His Ser Arg Lys Lys Arg Leu Ile Ser 
                245                 250                 255     


Tyr Pro Arg Tyr Ile Glu Ile Met Val Xaa Ala Asp Ala Lys Val Val 
            260                 265                 270         


Ser Ala His Gly Ser Asn Leu Gln Asn Tyr Ile Leu Xaa Leu Met Ser 
        275                 280                 285             


Ile Val Ala Xaa Ile Tyr Lys Asp Pro Ser Ile Gly Asn Leu Ile His 
    290                 295                 300                 


Ile Val Val Val Lys Leu Val Met Ile His Arg Glu Glu Glu Gly Pro 
305                 310                 315                 320 


Val Ile Asn Phe Asp Gly Ala Xaa Xaa Leu Lys Asn Phe Cys Ser Trp 
                325                 330                 335     


Gln Gln Xaa Gln Asn Asp Leu Asp Asp Val His Pro Ser His His Asp 
            340                 345                 350         


Xaa Ala Val Leu Ile Xaa Arg Tyr Asp Ile Cys Ser Ser Lys Glu Lys 
        355                 360                 365             


Cys Asn Met Leu Gly Leu Ser Tyr Leu Gly Xaa Ile Cys Asp Pro Leu 
    370                 375                 380                 


Gln Ser Cys Phe Ile Asn Glu Glu Lys Gly Leu Ile Ser Ala Phe Xaa 
385                 390                 395                 400 


Ile Ala His Glu Leu Gly His Xaa Leu Gly Val Gln His Asp Asp Asn 
                405                 410                 415     


Pro Arg Cys Lys Glu Met Lys Val Xaa Lys Tyr His Val Met Ala Pro 
            420                 425                 430         


Ala Leu Ser Phe His Met Ser Pro Trp Ser Trp Ser Asn Cys Ser Arg 
        435                 440                 445             


Lys Tyr Val Xaa Glu Phe Leu Asp Xaa Gly Tyr Gly Glu Cys Leu Leu 
    450                 455                 460                 


Asp Lys Pro Asp Glu Glu Ile Tyr Asn Leu Pro Ser Glu Leu Pro Gly 
465                 470                 475                 480 


Ser Arg Tyr Asp Gly Asn Lys Gln Cys Glu Leu Ala Phe Gly Pro Gly 
                485                 490                 495     


Ser Gln Met Cys Pro His Ile Asn Ile Cys Met His Leu Trp Cys Xaa 
            500                 505                 510         


Ser Xaa Glu Lys Leu His Lys Gly Cys Phe Xaa Gln His Val Pro Pro 
        515                 520                 525             


Ala Asp Gly Xaa Asp Cys Gly Pro Gly Met His Cys Arg His Gly Leu 
    530                 535                 540                 


Cys Val Asn Lys Glu Xaa Glu Xaa Arg Pro Val Asn Gly Glu Trp Gly 
545                 550                 555                 560 


Pro Trp Glu Pro Tyr Ser Ser Cys Ser Arg Xaa Cys Gly Gly Gly Ile 
                565                 570                 575     


Glu Ser Ala Xaa Arg Arg Cys Asn Arg Pro Glu Pro Arg Asn Gly Gly 
            580                 585                 590         


Asn Tyr Cys Val Gly Arg Arg Met Lys Phe Arg Ser Cys Asn Xaa Asp 
        595                 600                 605             


Ser Cys Pro Lys Gly Xaa Gln Asp Phe Arg Glu Lys Gln Cys Ser Asp 
    610                 615                 620                 


Phe Asn Gly Lys His Leu Asp Ile Ser Gly Ile Pro Ser Asn Val Arg 
625                 630                 635                 640 


Trp Leu Pro Arg Tyr Ser Gly Ile Gly Xaa Lys Asp Arg Cys Lys Leu 
                645                 650                 655     


Tyr Cys Gln Val Ala Gly Xaa Asn Tyr Phe Tyr Leu Leu Lys Asp Met 
            660                 665                 670         


Val Glu Asp Gly Xaa Pro Cys Gly Xaa His Ser Tyr Asn Ile Asp Cys 
        675                 680                 685             


Asn Cys Val Leu Lys Ala Ala Gly Cys Asp His Val Leu Asn Ser Ser 
    690                 695                 700                 


Ala Lys Ile Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys 
705                 710                 715                 720 


Lys Xaa Ile Xaa Gly Val Phe Asn Ser Ser His Tyr Gly Tyr Asn Val 
                725                 730                 735     


Val Val Lys Ile Pro Ala Gly Ala Xaa Asn Val Asp Ile Arg Gln Tyr 
            740                 745                 750         


Ser Tyr Ser Gly Gln Pro Asp Asp Ser Tyr Leu Ala Leu Ser Asp Ala 
        755                 760                 765             


Glu Gly Asn Phe Leu Phe Asn Gly Asn Phe Leu Leu Ser Xaa Ser Lys 
    770                 775                 780                 


Lys Glu Ile Asn Val Gln Gly Xaa Arg Xaa Val Ile Glu Tyr Ser Gly 
785                 790                 795                 800 


Ser Asn Asn Ala Val Glu Arg Ile Asn Ser Xaa Asn Arg Gln Glu Lys 
                805                 810                 815     


Glu Ile Leu Ile Glu Val Leu Cys Val Gly Asn Leu Tyr Asn Pro Asp 
            820                 825                 830         


Val His Tyr Ser Phe Asn Ile Pro Leu Glu Glu Arg Ser Asp Met Phe 
        835                 840                 845             


Xaa Trp Asp Pro Tyr Gly Pro Trp Glu Gly Cys Xaa Lys Met Cys Gln 
    850                 855                 860                 


Gly Leu Gln Arg Arg Asn Ile Xaa Cys Ile His Lys Ser Asp His Ser 
865                 870                 875                 880 


Val Val Ser Asp Lys Glu Cys Asp His Leu Pro Leu Pro Ser Phe Val 
                885                 890                 895     


Xaa Gln Ser Cys Asn Xaa Asp Cys Glu Leu Arg Trp His Val Ile Gly 
            900                 905                 910         


Lys Ser Glu Cys Ser Ser Gln Cys Gly Gln Gly Tyr Arg Xaa Leu Asp 
        915                 920                 925             


Ile His Cys Met Lys Tyr Ser Ile His Glu Gly Gln Xaa Val Gln Val 
    930                 935                 940                 


Asp Asp His Tyr Cys Gly Asp Gln Leu Lys Pro Pro Xaa Gln Glu Leu 
945                 950                 955                 960 


Cys His Gly Asn Cys Val Phe Xaa Arg Trp His Tyr Ser Glu Trp Ser 
                965                 970                 975     


Gln Cys Ser Arg Ser Cys Gly Gly Gly Glu Arg Ser Arg Glu Ser Tyr 
            980                 985                 990         


Cys Met Asn Asn Phe Gly His Arg  Leu Ala Asp Asn Glu  Cys Gln Glu 
        995                 1000                 1005             


Leu Ser  Arg Val Xaa Arg Glu  Asn Cys Asn Glu Phe  Ser Cys Pro 
    1010                 1015                 1020             


Ser Trp  Ala Ala Ser Glu Trp  Ser Glu Cys Leu Val  Xaa Cys Gly 
    1025                 1030                 1035             


Lys Gly  Xaa Lys Gln Arg Gln  Val Trp Cys Gln Leu  Asn Val Asp 
    1040                 1045                 1050             


His Leu  Ser Asp Gly Phe Cys  Asn Ser Ser Xaa Lys  Pro Glu Ser 
    1055                 1060                 1065             


Leu Ser  Pro Cys Glu Leu His  Xaa Cys Ala Ser Trp  Gln Val Gly 
    1070                 1075                 1080             


Pro Trp  Gly Pro Cys Xaa Xaa  Xaa Cys Gly His Gly  Tyr Gln Met 
    1085                 1090                 1095             


Arg Asp  Val Lys Cys Val Asn  Glu Leu Ala Ser Ala  Val Leu Glu 
    1100                 1105                 1110             


Asp Xaa  Glu Cys His Glu Ala  Ser Arg Pro Ser Asp  Arg Gln Ser 
    1115                 1120                 1125             


Cys Val  Leu Xaa Pro Cys Ser  Phe Ile Ser Lys Leu  Glu Xaa Ala 
    1130                 1135                 1140             


Leu Leu  Pro Xaa Val Leu Ile  Lys Lys Met Ala Gln  Trp Arg His 
    1145                 1150                 1155             


Gly Ser  Trp Xaa Pro Cys Ser  Val Ser Cys Gly Arg  Gly Xaa Gln 
    1160                 1165                 1170             


Ala Arg  Tyr Val Ser Cys Arg  Asp Ala Leu Asp Arg  Ile Ala Asp 
    1175                 1180                 1185             


Glu Ser  Tyr Cys Ala His Leu  Pro Arg Pro Ala Glu  Ile Trp Asp 
    1190                 1195                 1200             


Cys Phe  Xaa Pro Cys Gly Glu  Trp Gln Ala Gly Asp  Trp Ser Pro 
    1205                 1210                 1215             


Cys Ser  Ala Ser Cys Gly His  Gly Lys Xaa Xaa Arg  Gln Val Leu 
    1220                 1225                 1230             


Cys Met  Asn Tyr His Gln Pro  Ile Asp Glu Asn Tyr  Cys Asp Pro 
    1235                 1240                 1245             


Glu Val  Arg Pro Leu Met Glu  Gln Glu Cys Ser Leu  Ala Ala Cys 
    1250                 1255                 1260             


Pro Pro  Ala His Ser His Phe  Pro Ser Ser Pro Val  Gln Pro Ser 
    1265                 1270                 1275             


Tyr Tyr  Leu Ser Xaa Asn Leu  Pro Leu Xaa Gln Lys  Leu Glu Asp 
    1280                 1285                 1290             


Asn Glu  Asn Gln Val Val His  Pro Ser Val Arg Gly  Asn Gln Trp 
    1295                 1300                 1305             


Arg Xaa  Gly Pro Trp Gly Gln  Cys Ser Ser Ser Cys  Ser Gly Gly 
    1310                 1315                 1320             


Leu Gln  His Arg Ala Val Val  Cys Gln Asp Glu Asn  Gly Gln Ser 
    1325                 1330                 1335             


Ala Ser  Tyr Cys Asp Ala Ala  Ser Lys Pro Pro Glu  Leu Gln Gln 
    1340                 1345                 1350             


Cys Gly  Pro Gly Pro Cys Pro  Gln Trp Asn Tyr Gly  Asn Trp Gly 
    1355                 1360                 1365             


Glu Cys  Ser Gln Xaa Cys Gly  Gly Gly Ile Lys Ser  Arg Leu Val 
    1370                 1375                 1380             


Ile Cys  Gln Phe Pro Asn Gly  Gln Ile Leu Glu Asp  His Asn Cys 
    1385                 1390                 1395             


Glu Ile  Val Asn Lys Pro Pro  Ser Val Ile Gln Cys  His Met His 
    1400                 1405                 1410             


Ala Cys  Pro Ala Asp Val Ser  Trp His Gln Glu Pro  Trp Xaa Ser 
    1415                 1420                 1425             


Glu Asp  Leu Lys Val Lys Leu  Leu Pro Gln Arg Xaa  Ile Ile Leu 
    1430                 1435                 1440             


Trp Glu  Leu Met Lys Asn Ile  Phe Cys His Gly Lys  His Ser His 
    1445                 1450                 1455             


Met Tyr  Leu Ile Asn Val Val  Xaa Asp His Leu Leu  Tyr Pro Arg 
    1460                 1465                 1470             


His Cys  Asp Pro Glu Xaa Ile  Glu Xaa Tyr Phe Leu  Ser Leu Trp 
    1475                 1480                 1485             


Ser Leu  Gln Phe Xaa Trp Gly  Asp Leu Lys Tyr Tyr  Lys Asn Ser 
    1490                 1495                 1500             


Leu 
    


<210> 1531
<211> 634
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<400> 1531
Tyr Ser Phe Asn Ile Pro Leu Glu Glu Arg Ser Asp Met Phe Xaa Trp 
1               5                   10                  15      


Asp Pro Tyr Gly Pro Trp Glu Gly Cys Xaa Lys Met Cys Gln Gly Leu 
            20                  25                  30          


Gln Arg Arg Asn Ile Xaa Cys Ile His Lys Ser Asp His Ser Val Val 
        35                  40                  45              


Ser Asp Lys Glu Cys Asp His Leu Pro Leu Pro Ser Phe Val Xaa Gln 
    50                  55                  60                  


Ser Cys Asn Xaa Asp Cys Glu Leu Arg Trp His Val Ile Gly Lys Ser 
65                  70                  75                  80  


Glu Cys Ser Ser Gln Cys Gly Gln Gly Tyr Arg Xaa Leu Asp Ile His 
                85                  90                  95      


Cys Met Lys Tyr Ser Ile His Glu Gly Gln Xaa Val Gln Val Asp Asp 
            100                 105                 110         


His Tyr Cys Gly Asp Gln Leu Lys Pro Pro Xaa Gln Glu Leu Cys His 
        115                 120                 125             


Gly Asn Cys Val Phe Xaa Arg Trp His Tyr Ser Glu Trp Ser Gln Cys 
    130                 135                 140                 


Ser Arg Ser Cys Gly Gly Gly Glu Arg Ser Arg Glu Ser Tyr Cys Met 
145                 150                 155                 160 


Asn Asn Phe Gly His Arg Leu Ala Asp Asn Glu Cys Gln Glu Leu Ser 
                165                 170                 175     


Arg Val Xaa Arg Glu Asn Cys Asn Glu Phe Ser Cys Pro Ser Trp Ala 
            180                 185                 190         


Ala Ser Glu Trp Ser Glu Cys Leu Val Xaa Cys Gly Lys Gly Xaa Lys 
        195                 200                 205             


Gln Arg Gln Val Trp Cys Gln Leu Asn Val Asp His Leu Ser Asp Gly 
    210                 215                 220                 


Phe Cys Asn Ser Ser Xaa Lys Pro Glu Ser Leu Ser Pro Cys Glu Leu 
225                 230                 235                 240 


His Xaa Cys Ala Ser Trp Gln Val Gly Pro Trp Gly Pro Cys Xaa Xaa 
                245                 250                 255     


Xaa Cys Gly His Gly Tyr Gln Met Arg Asp Val Lys Cys Val Asn Glu 
            260                 265                 270         


Leu Ala Ser Ala Val Leu Glu Asp Xaa Glu Cys His Glu Ala Ser Arg 
        275                 280                 285             


Pro Ser Asp Arg Gln Cys Ser Val Ser Cys Gly Arg Gly Xaa Gln Ala 
    290                 295                 300                 


Arg Tyr Val Ser Cys Arg Asp Ala Leu Asp Arg Ile Ala Asp Glu Ser 
305                 310                 315                 320 


Tyr Cys Ala His Leu Pro Arg Pro Ala Glu Ile Trp Asp Cys Phe Xaa 
                325                 330                 335     


Pro Cys Gly Glu Trp Gln Ala Gly Asp Trp Ser Pro Cys Ser Ala Ser 
            340                 345                 350         


Cys Gly His Gly Lys Xaa Xaa Arg Gln Val Leu Cys Met Asn Tyr His 
        355                 360                 365             


Gln Pro Ile Asp Glu Asn Tyr Cys Asp Pro Glu Val Arg Pro Leu Met 
    370                 375                 380                 


Glu Gln Glu Cys Ser Leu Ala Ala Cys Pro Pro Ala His Ser His Phe 
385                 390                 395                 400 


Pro Ser Ser Pro Val Gln Pro Ser Tyr Tyr Leu Ser Xaa Asn Leu Pro 
                405                 410                 415     


Leu Xaa Gln Lys Leu Glu Asp Asn Glu Asn Gln Val Val His Pro Ser 
            420                 425                 430         


Val Arg Gly Asn Gln Trp Arg Xaa Gly Pro Trp Gly Ser Cys Ser Ser 
        435                 440                 445             


Ser Cys Ser Gly Gly Leu Gln His Arg Ala Val Val Cys Gln Asp Glu 
    450                 455                 460                 


Asn Gly Gln Ser Ala Ser Tyr Cys Asp Ala Ala Ser Lys Pro Pro Glu 
465                 470                 475                 480 


Leu Gln Gln Cys Gly Pro Gly Pro Cys Pro Gln Trp Asn Tyr Gly Asn 
                485                 490                 495     


Trp Gly Glu Cys Ser Gln Xaa Cys Gly Gly Gly Ile Lys Ser Arg Leu 
            500                 505                 510         


Val Ile Cys Gln Phe Pro Asn Gly Gln Ile Leu Glu Asp His Asn Cys 
        515                 520                 525             


Glu Ile Val Asn Lys Pro Pro Ser Val Ile Gln Cys His Met His Ala 
    530                 535                 540                 


Cys Pro Ala Asp Val Ser Trp His Gln Glu Pro Trp Xaa Ser Glu Asp 
545                 550                 555                 560 


Leu Lys Val Lys Leu Leu Pro Gln Arg Xaa Ile Ile Leu Trp Glu Leu 
                565                 570                 575     


Met Lys Asn Ile Phe Cys His Gly Lys His Ser His Met Tyr Leu Ile 
            580                 585                 590         


Asn Val Val Xaa Asp His Leu Leu Tyr Pro Arg His Cys Asp Pro Glu 
        595                 600                 605             


Xaa Ile Glu Xaa Tyr Phe Leu Ser Leu Trp Ser Leu Gln Phe Xaa Trp 
    610                 615                 620                 


Gly Asp Leu Lys Tyr Tyr Lys Asn Ser Leu 
625                 630                 


<210> 1532
<211> 1205
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1184)..(1184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<400> 1532
Met Val Leu Leu Ser Leu Trp Leu Ile Ala Ala Ala Leu Val Glu Val 
1               5                   10                  15      


Arg Xaa Ser Ala Asp Gly Gln Ala Gly Asn Glu Glu Met Val Gln Ile 
            20                  25                  30          


Asp Leu Pro Ile Lys Arg Tyr Arg Glu Tyr Glu Leu Val Xaa Pro Val 
        35                  40                  45              


Ser Xaa Asn Leu Glu Gly Arg Tyr Leu Ser His Xaa Leu Ser Ala Ser 
    50                  55                  60                  


His Lys Lys Arg Ser Ala Arg Asp Val Ser Ser Asn Pro Glu Gln Leu 
65                  70                  75                  80  


Phe Phe Asn Ile Xaa Ala Phe Gly Lys Asp Phe His Leu Arg Leu Lys 
                85                  90                  95      


Pro Asn Xaa Gln Leu Val Ala Pro Gly Ala Val Val Glu Trp His Glu 
            100                 105                 110         


Xaa Ser Leu Val Pro Gly Asn Ile Xaa Asp Pro Ile Asn Asn His Gln 
        115                 120                 125             


Pro Gly Ser Ala Xaa Tyr Arg Ile Arg Arg Xaa Glu Pro Leu Gln Xaa 
    130                 135                 140                 


Asn Cys Ala Tyr Val Gly Asp Ile Val Asp Ile Pro Gly Xaa Ser Val 
145                 150                 155                 160 


Ala Ile Ser Asn Cys Asp Gly Leu Ala Gly Met Ile Lys Ser Asp Asn 
                165                 170                 175     


Glu Glu Tyr Phe Ile Glu Pro Leu Glu Arg Gly Lys Gln Met Glu Glu 
            180                 185                 190         


Glu Lys Gly Arg Ile His Val Val Tyr Lys Arg Ser Ala Val Glu Gln 
        195                 200                 205             


Ala Pro Ile Asp Met Ser Lys Asp Phe His Tyr Arg Glu Ser Asp Leu 
    210                 215                 220                 


Glu Gly Leu Asp Asp Leu Gly Xaa Val Tyr Gly Asn Ile His Gln Gln 
225                 230                 235                 240 


Leu Asn Glu Xaa Met Arg Arg Arg Arg His Ala Gly Glu Asn Asp Tyr 
                245                 250                 255     


Asn Ile Glu Val Leu Leu Gly Val Asp Asp Ser Val Val Arg Phe His 
            260                 265                 270         


Gly Lys Glu His Val Gln Asn Tyr Leu Leu Xaa Leu Met Asn Ile Val 
        275                 280                 285             


Asn Glu Ile Tyr His Asp Glu Ser Leu Gly Val His Ile Asn Val Val 
    290                 295                 300                 


Leu Val Arg Met Ile Met Leu Gly Tyr Ala Lys Ser Ile Ser Leu Ile 
305                 310                 315                 320 


Glu Arg Gly Asn Pro Ser Arg Ser Leu Glu Asn Val Cys Arg Trp Ala 
                325                 330                 335     


Ser Gln Gln Gln Arg Ser Asp Leu Asn His Ser Glu His His Asp His 
            340                 345                 350         


Ala Ile Phe Leu Xaa Arg Gln Asp Phe Gly Pro Ala Gly Met Gln Gly 
        355                 360                 365             


Tyr Ala Pro Val Xaa Gly Met Cys His Pro Val Arg Ser Cys Xaa Leu 
    370                 375                 380                 


Asn His Glu Asp Gly Phe Ser Ser Ala Phe Val Val Ala His Glu Xaa 
385                 390                 395                 400 


Gly His Val Leu Gly Met Glu His Asp Gly Gln Gly Asn Arg Cys Gly 
                405                 410                 415     


Asp Glu Xaa Ala Met Gly Ser Val Met Ala Pro Leu Val Gln Ala Ala 
            420                 425                 430         


Phe His Arg Tyr His Trp Ser Arg Cys Ser Gly Gln Glu Leu Lys Arg 
        435                 440                 445             


Tyr Ile His Ser Tyr Asp Cys Leu Leu Asp Asp Pro Phe Asp His Asp 
    450                 455                 460                 


Trp Pro Lys Leu Pro Glu Leu Pro Gly Ile Asn Tyr Ser Met Asp Glu 
465                 470                 475                 480 


Gln Cys Arg Phe Asp Phe Gly Val Gly Tyr Lys Met Cys Xaa Ala Phe 
                485                 490                 495     


Arg Xaa Phe Asp Pro Cys Lys Gln Leu Trp Cys Ser His Pro Asp Asn 
            500                 505                 510         


Pro Tyr Phe Cys Lys Xaa Lys Lys Gly Pro Pro Leu Asp Gly Xaa Glu 
        515                 520                 525             


Cys Ala Ala Gly Lys Trp Cys Tyr Lys Gly His Cys Met Trp Lys Asn 
    530                 535                 540                 


Ala Asn Gln Gln Lys Gln Asp Gly Asn Trp Gly Ser Trp Xaa Lys Phe 
545                 550                 555                 560 


Gly Ser Cys Ser Arg Xaa Cys Gly Xaa Gly Val Arg Phe Arg Xaa Arg 
                565                 570                 575     


Gln Cys Asn Asn Pro Met Pro Ile Asn Gly Gly Gln Asp Cys Pro Gly 
            580                 585                 590         


Val Asn Phe Glu Tyr Gln Leu Cys Asn Xaa Glu Glu Cys Gln Lys His 
        595                 600                 605             


Phe Glu Asp Phe Arg Ala Gln Gln Cys Gln Gln Arg Asn Ser His Phe 
    610                 615                 620                 


Glu Tyr Gln Asn Xaa Lys His His Trp Leu Pro Tyr Glu His Pro Asp 
625                 630                 635                 640 


Pro Lys Lys Arg Cys His Leu Tyr Cys Gln Ser Lys Glu Xaa Gly Asp 
                645                 650                 655     


Val Ala Tyr Met Lys Gln Leu Val His Asp Gly Xaa His Cys Ser Tyr 
            660                 665                 670         


Lys Asp Pro Tyr Ser Ile Cys Val Arg Gly Glu Cys Val Lys Val Gly 
        675                 680                 685             


Cys Asp Lys Glu Ile Gly Ser Asn Lys Val Glu Asp Lys Cys Gly Val 
    690                 695                 700                 


Cys Gly Gly Asp Asn Ser His Cys Arg Xaa Val Lys Gly Xaa Phe Xaa 
705                 710                 715                 720 


Arg Xaa Pro Arg Lys Leu Gly Tyr Leu Lys Met Phe Asp Ile Pro Pro 
                725                 730                 735     


Gly Ala Arg His Val Leu Ile Gln Glu Asp Glu Ala Ser Pro His Ile 
            740                 745                 750         


Leu Ala Ile Lys Asn Gln Ala Xaa Gly His Tyr Ile Leu Asn Gly Lys 
        755                 760                 765             


Gly Glu Glu Ala Lys Ser Arg Xaa Phe Ile Asp Leu Gly Val Glu Trp 
    770                 775                 780                 


Asp Tyr Asn Ile Glu Asp Asp Ile Glu Ser Leu His Xaa Asp Gly Pro 
785                 790                 795                 800 


Leu His Asp Pro Val Ile Val Leu Ile Ile Pro Gln Glu Asn Asp Xaa 
                805                 810                 815     


Arg Ser Ser Leu Xaa Tyr Lys Tyr Ile Ile His Glu Asp Ser Val Pro 
            820                 825                 830         


Xaa Ile Asn Ser Asn Asn Val Ile Gln Glu Glu Leu Asp Xaa Phe Glu 
        835                 840                 845             


Trp Ala Leu Lys Ser Trp Ser Gln Cys Ser Lys Pro Cys Gly Gly Gly 
    850                 855                 860                 


Phe Gln Tyr Xaa Lys Tyr Gly Cys Arg Arg Lys Ser Asp Asn Lys Met 
865                 870                 875                 880 


Val His Arg Ser Phe Cys Glu Ala Asn Lys Lys Pro Lys Pro Ile Arg 
                885                 890                 895     


Arg Met Cys Asn Ile Gln Glu Cys Xaa His Pro Leu Trp Val Ala Glu 
            900                 905                 910         


Glu Trp Glu His Cys Xaa Lys Xaa Cys Gly Ser Ser Gly Tyr Gln Leu 
        915                 920                 925             


Arg Xaa Val Arg Cys Leu Gln Pro Leu Leu Asp Gly Xaa Asn Arg Ser 
    930                 935                 940                 


Val His Ser Lys Tyr Cys Met Gly Asp Arg Pro Glu Ser Arg Arg Pro 
945                 950                 955                 960 


Cys Asn Arg Val Pro Cys Pro Ala Gln Trp Lys Xaa Gly Pro Trp Ser 
                965                 970                 975     


Glu Cys Ser Val Xaa Cys Gly Glu Gly Xaa Glu Val Arg Gln Val Leu 
            980                 985                 990         


Cys Arg Ala Gly Asp His Cys Asp  Gly Glu Lys Pro Glu  Ser Val Arg 
        995                 1000                 1005             


Ala Cys  Gln Leu Pro Pro Cys  Asn Asp Glu Pro Cys  Leu Gly Asp 
    1010                 1015                 1020             


Lys Ser  Ile Phe Cys Gln Met  Glu Val Leu Ala Arg  Tyr Cys Ser 
    1025                 1030                 1035             


Ile Pro  Gly Tyr Asn Lys Leu  Cys Cys Glu Ser Cys  Ser Lys Arg 
    1040                 1045                 1050             


Ser Ser  Xaa Leu Pro Pro Pro  Tyr Leu Leu Glu Ala  Ala Glu Xaa 
    1055                 1060                 1065             


His Asp  Asp Val Ile Ser Asn  Pro Ser Asp Leu Pro  Arg Ser Leu 
    1070                 1075                 1080             


Val Met  Pro Xaa Ser Leu Val  Pro Tyr His Ser Glu  Xaa Pro Ala 
    1085                 1090                 1095             


Lys Lys  Met Ser Leu Ser Ser  Ile Ser Ser Val Gly  Gly Pro Asn 
    1100                 1105                 1110             


Ala Tyr  Ala Ala Phe Arg Pro  Asn Ser Lys Pro Asp  Gly Ala Asn 
    1115                 1120                 1125             


Leu Arg  Gln Arg Ser Ala Gln  Gln Ala Gly Ser Lys  Xaa Val Arg 
    1130                 1135                 1140             


Leu Val  Xaa Val Pro Ser Ser  Pro Pro Xaa Lys Arg  Val His Leu 
    1145                 1150                 1155             


Ser Ser  Ala Ser Gln Met Ala  Ala Ala Ser Phe Phe  Ala Ala Ser 
    1160                 1165                 1170             


Asp Ser  Ile Gly Ala Ser Ser  Gln Ala Arg Xaa Ser  Lys Lys Asp 
    1175                 1180                 1185             


Gly Lys  Ile Ile Asp Asn Arg  Arg Pro Xaa Arg Ser  Ser Xaa Leu 
    1190                 1195                 1200             


Glu Arg  
    1205 


<210> 1533
<211> 951
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<400> 1533
Met Asp Gly Arg Trp Gln Cys Ser Cys Trp Ala Trp Phe Leu Leu Val 
1               5                   10                  15      


Leu Ala Val Val Ala Gly Asp Xaa Val Ser Xaa Gly Ser Xaa Asp Asn 
            20                  25                  30          


Ser Pro Xaa Ser Asn Ser Leu Glu Gly Gly Xaa Asp Ala Xaa Ala Phe 
        35                  40                  45              


Trp Trp Gly Glu Trp Xaa Lys Trp Xaa Ala Cys Ser Arg Ser Cys Gly 
    50                  55                  60                  


Gly Gly Val Xaa Ser Gln Glu Arg His Cys Leu Gln Gln Arg Arg Lys 
65                  70                  75                  80  


Ser Val Pro Gly Pro Gly Asn Arg Xaa Cys Xaa Gly Xaa Ser Lys Arg 
                85                  90                  95      


Tyr Gln Leu Cys Arg Val Gln Glu Cys Pro Pro Asp Gly Arg Ser Phe 
            100                 105                 110         


Arg Glu Glu Gln Cys Val Ser Phe Asn Ser His Val Tyr Asn Gly Arg 
        115                 120                 125             


Xaa His Gln Trp Lys Pro Leu Tyr Pro Asp Asp Tyr Val His Ile Ser 
    130                 135                 140                 


Ser Lys Pro Cys Asp Leu His Cys Xaa Xaa Val Asp Gly Gln Arg Gln 
145                 150                 155                 160 


Leu Met Val Pro Ala Arg Asp Gly Xaa Ser Cys Lys Leu Xaa Asp Leu 
                165                 170                 175     


Arg Gly Val Cys Val Ser Gly Lys Cys Glu Pro Ile Gly Cys Asp Gly 
            180                 185                 190         


Val Leu Phe Ser Xaa His Xaa Leu Asp Lys Cys Gly Ile Cys Gln Gly 
        195                 200                 205             


Asp Gly Ser Ser Cys Xaa His Val Xaa Gly Asn Tyr Arg Lys Gly Asn 
    210                 215                 220                 


Ala His Leu Gly Tyr Ser Leu Val Xaa His Ile Pro Ala Gly Ala Arg 
225                 230                 235                 240 


Asp Ile Gln Ile Val Glu Arg Lys Lys Ser Ala Asp Val Leu Ala Leu 
                245                 250                 255     


Ala Asp Glu Ala Gly Tyr Tyr Phe Phe Asn Gly Asn Tyr Lys Val Asp 
            260                 265                 270         


Ser Pro Lys Asn Phe Asn Ile Ala Gly Xaa Val Val Lys Tyr Arg Arg 
        275                 280                 285             


Pro Met Asp Val Tyr Glu Xaa Gly Ile Glu Tyr Ile Val Ala Gln Gly 
    290                 295                 300                 


Pro Xaa Asn Gln Gly Leu Asn Val Met Val Trp Asn Gln Asn Gly Lys 
305                 310                 315                 320 


Ser Pro Ser Ile Xaa Phe Glu Tyr Xaa Leu Leu Gln Pro Pro His Glu 
                325                 330                 335     


Ser Arg Pro Gln Pro Ile Tyr Tyr Gly Phe Ser Glu Ser Ala Glu Ser 
            340                 345                 350         


Gln Gly Leu Asp Gly Ala Gly Leu Met Gly Phe Val Pro His Asn Gly 
        355                 360                 365             


Ser Leu Tyr Gly Gln Ala Ser Ser Glu Arg Leu Gly Leu Asp Asn Arg 
    370                 375                 380                 


Leu Phe Gly His Pro Gly Leu Asp Met Glu Leu Gly Pro Ser Gln Gly 
385                 390                 395                 400 


Gln Glu Xaa Asn Glu Val Cys Glu Gln Ala Gly Gly Gly Ala Cys Glu 
                405                 410                 415     


Gly Pro Pro Arg Gly Lys Gly Phe Arg Asp Arg Asn Val Xaa Gly Xaa 
            420                 425                 430         


Pro Leu Xaa Gly Asp Lys Asp Asp Glu Glu Val Asp Xaa His Phe Ala 
        435                 440                 445             


Ser Gln Glu Phe Phe Ser Ala Asn Ala Ile Ser Asp Gln Leu Leu Gly 
    450                 455                 460                 


Ala Gly Ser Asp Leu Lys Asp Phe Xaa Leu Asn Glu Xaa Val Asn Ser 
465                 470                 475                 480 


Ile Phe Ala Gln Gly Ala Pro Arg Ser Ser Leu Ala Glu Ser Phe Phe 
                485                 490                 495     


Val Asp Tyr Glu Glu Asn Glu Gly Ala Gly Pro Tyr Leu Leu Asn Gly 
            500                 505                 510         


Ser Tyr Leu Glu Leu Ser Ser Asp Arg Val Ala Asn Ser Ser Ser Glu 
        515                 520                 525             


Ala Pro Phe Pro Asn Val Ser Xaa Ser Leu Leu Xaa Ser Ala Gly Asn 
    530                 535                 540                 


Arg Xaa His Lys Ala Arg Xaa Arg Pro Lys Ala Arg Lys Gln Gly Val 
545                 550                 555                 560 


Ser Pro Ala Asp Met Tyr Arg Trp Lys Leu Ser Ser His Glu Pro Cys 
                565                 570                 575     


Ser Ala Xaa Cys Xaa Xaa Gly Val Met Ser Ala Tyr Ala Met Cys Val 
            580                 585                 590         


Arg Tyr Asp Gly Val Glu Val Asp Asp Ser Tyr Cys Asp Ala Leu Xaa 
        595                 600                 605             


Arg Pro Glu Pro Val His Glu Phe Cys Ala Gly Arg Glu Cys Gln Pro 
    610                 615                 620                 


Arg Trp Glu Xaa Ser Ser Trp Ser Glu Cys Ser Arg Xaa Cys Gly Glu 
625                 630                 635                 640 


Gly Tyr Gln Phe Arg Val Val Arg Cys Trp Lys Met Leu Ser Pro Gly 
                645                 650                 655     


Phe Asp Ser Ser Val Tyr Ser Asp Leu Cys Glu Ala Ala Glu Ala Val 
            660                 665                 670         


Arg Pro Glu Glu Arg Lys Xaa Cys Arg Asn Pro Ala Cys Gly Pro Gln 
        675                 680                 685             


Trp Glu Met Ser Glu Trp Ser Glu Cys Xaa Ala Lys Cys Gly Glu Arg 
    690                 695                 700                 


Ser Val Val Xaa Arg Asp Ile Arg Cys Ser Glu Asp Glu Lys Leu Cys 
705                 710                 715                 720 


Asp Pro Asn Xaa Arg Pro Val Gly Glu Lys Asn Cys Xaa Gly Pro Pro 
                725                 730                 735     


Cys Asp Arg Gln Trp Xaa Val Ser Asp Trp Gly Pro Cys Ser Gly Ser 
            740                 745                 750         


Cys Gly Gln Gly Arg Xaa Ile Arg His Val Tyr Cys Lys Xaa Ser Asp 
        755                 760                 765             


Gly Arg Val Val Pro Glu Ser Gln Cys Gln Met Glu Xaa Lys Pro Leu 
    770                 775                 780                 


Ala Ile His Pro Cys Gly Asp Lys Asn Cys Pro Ala His Trp Leu Ala 
785                 790                 795                 800 


Gln Asp Trp Glu Arg Cys Asn Xaa Xaa Cys Gly Arg Gly Val Lys Lys 
                805                 810                 815     


Arg Leu Val Leu Cys Met Glu Leu Ala Asn Gly Lys Pro Gln Xaa Arg 
            820                 825                 830         


Ser Gly Pro Glu Cys Gly Leu Ala Lys Lys Pro Pro Glu Glu Ser Xaa 
        835                 840                 845             


Cys Phe Glu Arg Pro Cys Phe Lys Trp Tyr Xaa Ser Pro Trp Ser Glu 
    850                 855                 860                 


Cys Xaa Lys Xaa Cys Gly Val Gly Val Arg Met Arg Asp Val Lys Cys 
865                 870                 875                 880 


Tyr Gln Gly Xaa Asp Ile Val Arg Gly Cys Asp Pro Leu Val Lys Pro 
                885                 890                 895     


Val Gly Arg Gln Ala Cys Asp Leu Gln Pro Cys Pro Xaa Glu Pro Pro 
            900                 905                 910         


Asp Asp Ser Cys Gln Asp Gln Pro Gly Xaa Asn Cys Ala Leu Ala Ile 
        915                 920                 925             


Lys Val Asn Leu Cys Gly His Trp Tyr Tyr Ser Lys Ala Cys Cys Arg 
    930                 935                 940                 


Ser Cys Arg Pro Pro His Ser 
945                 950     


<210> 1534
<211> 1060
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<400> 1534
Met Leu Phe Glu Val Gly Glu Gly Gly Gly Ala Gly Glu Glu Gly Lys 
1               5                   10                  15      


Gly Arg Gly Arg Pro Gly Arg Ser Leu Cys Xaa His Ala Ala Pro Ala 
            20                  25                  30          


Arg Xaa Ala His Leu Ala Pro Ser Ala Leu Arg Ser Ala Arg Pro Phe 
        35                  40                  45              


Leu Trp Glu Asp Asn Leu Leu Xaa Arg Ser Gln Gly Leu Pro Asp Asn 
    50                  55                  60                  


His Asp Gln Leu Val Pro Asp Asn Leu Glu Ala Trp Ala Leu Ala Gly 
65                  70                  75                  80  


Pro Arg Gly Leu Phe Pro Lys Arg Xaa Leu Val Ile Trp Lys Arg Ile 
                85                  90                  95      


Gly Ala Gly Leu Val Val Xaa Val Ala Leu Leu Pro Arg Met Asp Gly 
            100                 105                 110         


Arg Trp Gln Cys Ser Cys Trp Ala Trp Phe Leu Leu Val Leu Ala Val 
        115                 120                 125             


Val Ala Gly Asp Xaa Val Ser Xaa Gly Ser Xaa Asp Asn Ser Pro Xaa 
    130                 135                 140                 


Ser Asn Ser Leu Glu Gly Gly Xaa Asp Ala Xaa Ala Phe Trp Trp Gly 
145                 150                 155                 160 


Glu Trp Xaa Lys Trp Xaa Ala Cys Ser Arg Ser Cys Gly Gly Gly Val 
                165                 170                 175     


Xaa Ser Gln Glu Arg His Cys Leu Gln Gln Arg Arg Lys Ser Val Pro 
            180                 185                 190         


Gly Pro Gly Asn Arg Xaa Cys Xaa Gly Xaa Ser Lys Arg Tyr Gln Leu 
        195                 200                 205             


Cys Arg Val Gln Glu Cys Pro Pro Asp Gly Arg Ser Phe Arg Glu Glu 
    210                 215                 220                 


Gln Cys Val Ser Phe Asn Ser His Val Tyr Asn Gly Arg Xaa His Gln 
225                 230                 235                 240 


Trp Lys Pro Leu Tyr Pro Asp Asp Tyr Val His Ile Ser Ser Lys Pro 
                245                 250                 255     


Cys Asp Leu His Cys Xaa Xaa Val Asp Gly Gln Arg Gln Leu Met Val 
            260                 265                 270         


Pro Ala Arg Asp Gly Xaa Ser Cys Lys Leu Xaa Asp Leu Arg Gly Val 
        275                 280                 285             


Cys Val Ser Gly Lys Cys Glu Pro Ile Gly Cys Asp Gly Val Leu Phe 
    290                 295                 300                 


Ser Xaa His Xaa Leu Asp Lys Cys Gly Ile Cys Gln Gly Asp Gly Ser 
305                 310                 315                 320 


Ser Cys Xaa His Val Xaa Gly Asn Tyr Arg Lys Gly Asn Ala His Leu 
                325                 330                 335     


Gly Tyr Ser Leu Val Xaa His Ile Pro Ala Gly Ala Arg Asp Ile Gln 
            340                 345                 350         


Ile Val Glu Arg Lys Lys Ser Ala Asp Val Leu Ala Leu Ala Asp Glu 
        355                 360                 365             


Ala Gly Tyr Tyr Phe Phe Asn Gly Asn Tyr Lys Val Asp Ser Pro Lys 
    370                 375                 380                 


Asn Phe Asn Ile Ala Gly Xaa Val Val Lys Tyr Arg Arg Pro Met Asp 
385                 390                 395                 400 


Val Tyr Glu Xaa Gly Ile Glu Tyr Ile Val Ala Gln Gly Pro Xaa Asn 
                405                 410                 415     


Gln Gly Leu Asn Val Met Val Trp Asn Gln Asn Gly Lys Ser Pro Ser 
            420                 425                 430         


Ile Xaa Phe Glu Tyr Xaa Leu Leu Gln Pro Pro His Glu Ser Arg Pro 
        435                 440                 445             


Gln Pro Ile Tyr Tyr Gly Phe Ser Glu Ser Ala Glu Ser Gln Gly Leu 
    450                 455                 460                 


Asp Gly Ala Gly Leu Met Gly Phe Val Pro His Asn Gly Ser Leu Tyr 
465                 470                 475                 480 


Gly Gln Ala Ser Ser Glu Arg Leu Gly Leu Asp Asn Arg Leu Phe Gly 
                485                 490                 495     


His Pro Gly Leu Asp Met Glu Leu Gly Pro Ser Gln Gly Gln Glu Xaa 
            500                 505                 510         


Asn Glu Val Cys Glu Gln Ala Gly Gly Gly Ala Cys Glu Gly Pro Pro 
        515                 520                 525             


Arg Gly Lys Gly Phe Arg Asp Arg Asn Val Xaa Gly Xaa Pro Leu Xaa 
    530                 535                 540                 


Gly Asp Lys Asp Asp Glu Glu Val Asp Xaa His Phe Ala Ser Gln Glu 
545                 550                 555                 560 


Phe Phe Ser Ala Asn Ala Ile Ser Asp Gln Leu Leu Gly Ala Gly Ser 
                565                 570                 575     


Asp Leu Lys Asp Phe Xaa Leu Asn Glu Xaa Val Asn Ser Ile Phe Ala 
            580                 585                 590         


Gln Gly Ala Pro Arg Ser Ser Leu Ala Glu Ser Phe Phe Val Asp Tyr 
        595                 600                 605             


Glu Glu Asn Glu Gly Ala Gly Pro Tyr Leu Leu Asn Gly Ser Tyr Leu 
    610                 615                 620                 


Glu Leu Ser Ser Asp Arg Val Ala Asn Ser Ser Ser Glu Ala Pro Phe 
625                 630                 635                 640 


Pro Asn Val Ser Xaa Ser Leu Leu Xaa Ser Ala Gly Asn Arg Xaa His 
                645                 650                 655     


Lys Ala Arg Xaa Arg Pro Lys Ala Arg Lys Gln Gly Val Ser Pro Ala 
            660                 665                 670         


Asp Met Tyr Arg Trp Lys Leu Ser Ser His Glu Pro Cys Ser Ala Xaa 
        675                 680                 685             


Cys Xaa Xaa Gly Val Met Ser Ala Tyr Ala Met Cys Val Arg Tyr Asp 
    690                 695                 700                 


Gly Val Glu Val Asp Asp Ser Tyr Cys Asp Ala Leu Xaa Arg Pro Glu 
705                 710                 715                 720 


Pro Val His Glu Phe Cys Ala Gly Arg Glu Cys Gln Pro Arg Trp Glu 
                725                 730                 735     


Xaa Ser Ser Trp Ser Glu Cys Ser Arg Xaa Cys Gly Glu Gly Tyr Gln 
            740                 745                 750         


Phe Arg Val Val Arg Cys Trp Lys Met Leu Ser Pro Gly Phe Asp Ser 
        755                 760                 765             


Ser Val Tyr Ser Asp Leu Cys Glu Ala Ala Glu Ala Val Arg Pro Glu 
    770                 775                 780                 


Glu Arg Lys Xaa Cys Arg Asn Pro Ala Cys Gly Pro Gln Trp Glu Met 
785                 790                 795                 800 


Ser Glu Trp Ser Glu Cys Xaa Ala Lys Cys Gly Glu Arg Ser Val Val 
                805                 810                 815     


Xaa Arg Asp Ile Arg Cys Ser Glu Asp Glu Lys Leu Cys Asp Pro Asn 
            820                 825                 830         


Xaa Arg Pro Val Gly Glu Lys Asn Cys Xaa Gly Pro Pro Cys Asp Arg 
        835                 840                 845             


Gln Trp Xaa Val Ser Asp Trp Gly Pro Cys Ser Gly Ser Cys Gly Gln 
    850                 855                 860                 


Gly Arg Xaa Ile Arg His Val Tyr Cys Lys Xaa Ser Asp Gly Arg Val 
865                 870                 875                 880 


Val Pro Glu Ser Gln Cys Gln Met Glu Xaa Lys Pro Leu Ala Ile His 
                885                 890                 895     


Pro Cys Gly Asp Lys Asn Cys Pro Ala His Trp Leu Ala Gln Asp Trp 
            900                 905                 910         


Glu Arg Cys Asn Xaa Xaa Cys Gly Arg Gly Val Lys Lys Arg Leu Val 
        915                 920                 925             


Leu Cys Met Glu Leu Ala Asn Gly Lys Pro Gln Xaa Arg Ser Gly Pro 
    930                 935                 940                 


Glu Cys Gly Leu Ala Lys Lys Pro Pro Glu Glu Ser Xaa Cys Phe Glu 
945                 950                 955                 960 


Arg Pro Cys Phe Lys Trp Tyr Xaa Ser Pro Trp Ser Glu Cys Xaa Lys 
                965                 970                 975     


Xaa Cys Gly Val Gly Val Arg Met Arg Asp Val Lys Cys Tyr Gln Gly 
            980                 985                 990         


Xaa Asp Ile Val Arg Gly Cys Asp  Pro Leu Val Lys Pro  Val Gly Arg 
        995                 1000                 1005             


Gln Ala  Cys Asp Leu Gln Pro  Cys Pro Xaa Glu Pro  Pro Asp Asp 
    1010                 1015                 1020             


Ser Cys  Gln Asp Gln Pro Gly  Xaa Asn Cys Ala Leu  Ala Ile Lys 
    1025                 1030                 1035             


Val Asn  Leu Cys Gly His Trp  Tyr Tyr Ser Lys Ala  Cys Cys Arg 
    1040                 1045                 1050             


Ser Cys  Arg Pro Pro His Ser  
    1055                 1060 


<210> 1535
<211> 374
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<400> 1535
Met Ala Lys Glu Arg Arg Arg Ala Val Leu Glu Leu Leu Gln Arg Pro 
1               5                   10                  15      


Gly Asn Ala Arg Cys Ala Asp Cys Gly Ala Pro Asp Pro Asp Trp Ala 
            20                  25                  30          


Ser Tyr Xaa Leu Gly Val Phe Ile Cys Leu Ser Cys Ser Gly Ile His 
        35                  40                  45              


Arg Asn Ile Pro Gln Val Ser Lys Val Lys Ser Val Arg Leu Asp Ala 
    50                  55                  60                  


Trp Glu Glu Ala Gln Val Glu Phe Met Ala Ser His Gly Asn Asp Ala 
65                  70                  75                  80  


Ala Arg Ala Arg Phe Glu Ser Lys Val Pro Ser Phe Tyr Tyr Arg Pro 
                85                  90                  95      


Xaa Pro Ser Asp Cys Gln Leu Leu Arg Glu Gln Trp Ile Arg Ala Lys 
            100                 105                 110         


Tyr Glu Arg Gln Glu Phe Ile Tyr Pro Glu Lys Gln Glu Pro Tyr Ser 
        115                 120                 125             


Ala Gly Tyr Arg Glu Gly Phe Leu Trp Lys Arg Gly Arg Asp Asn Gly 
    130                 135                 140                 


Gln Phe Leu Ser Arg Lys Phe Val Leu Xaa Glu Arg Glu Gly Ala Leu 
145                 150                 155                 160 


Lys Tyr Phe Asn Arg Asn Asp Ala Lys Glu Pro Lys Ala Val Met Lys 
                165                 170                 175     


Ile Glu His Leu Asn Ala Xaa Phe Gln Pro Ala Lys Ile Gly His Pro 
            180                 185                 190         


His Gly Leu Gln Val Xaa Tyr Leu Lys Asp Asn Ser Xaa Arg Asn Ile 
        195                 200                 205             


Phe Ile Tyr His Glu Asp Gly Lys Glu Ile Val Asp Trp Phe Asn Ala 
    210                 215                 220                 


Leu Arg Ala Ala Arg Phe His Tyr Leu Gln Val Ala Phe Pro Gly Ala 
225                 230                 235                 240 


Gly Asp Ala Asp Leu Val Pro Lys Leu Ser Arg Asn Tyr Leu Lys Glu 
                245                 250                 255     


Gly Tyr Met Glu Lys Xaa Gly Pro Lys Gln Xaa Glu Gly Phe Arg Lys 
            260                 265                 270         


Arg Trp Phe Xaa Met Asp Asp Arg Arg Leu Met Tyr Phe Lys Asp Pro 
        275                 280                 285             


Leu Asp Ala Phe Ala Arg Gly Glu Val Phe Ile Gly Ser Lys Glu Ser 
    290                 295                 300                 


Gly Tyr Xaa Val Leu His Gly Phe Pro Pro Ser Xaa Gln Gly His His 
305                 310                 315                 320 


Trp Pro His Gly Ile Xaa Ile Val Xaa Pro Asp Arg Lys Phe Leu Phe 
                325                 330                 335     


Ala Cys Glu Xaa Glu Ser Asp Gln Arg Glu Trp Val Ala Ala Phe Gln 
            340                 345                 350         


Lys Ala Val Asp Arg Pro Met Leu Pro Gln Glu Tyr Ala Val Glu Ala 
        355                 360                 365             


His Phe Lys His Lys Pro 
    370                 


<210> 1536
<211> 302
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<400> 1536
Met Ala Ser His Gly Asn Asp Ala Ala Arg Ala Arg Phe Glu Ser Lys 
1               5                   10                  15      


Val Pro Ser Phe Tyr Tyr Arg Pro Xaa Pro Ser Asp Cys Gln Leu Leu 
            20                  25                  30          


Arg Glu Gln Trp Ile Arg Ala Lys Tyr Glu Arg Gln Glu Phe Ile Tyr 
        35                  40                  45              


Pro Glu Lys Gln Glu Pro Tyr Ser Ala Gly Tyr Arg Glu Gly Phe Leu 
    50                  55                  60                  


Trp Lys Arg Gly Arg Asp Asn Gly Gln Phe Leu Ser Arg Lys Phe Val 
65                  70                  75                  80  


Leu Xaa Glu Arg Glu Gly Ala Leu Lys Tyr Phe Asn Arg Asn Asp Ala 
                85                  90                  95      


Lys Glu Pro Lys Ala Val Met Lys Ile Glu His Leu Asn Ala Xaa Phe 
            100                 105                 110         


Gln Pro Ala Lys Ile Gly His Pro His Gly Leu Gln Val Xaa Tyr Leu 
        115                 120                 125             


Lys Asp Asn Ser Xaa Arg Asn Ile Phe Ile Tyr His Glu Asp Gly Lys 
    130                 135                 140                 


Glu Ile Val Asp Trp Phe Asn Ala Leu Arg Ala Ala Arg Phe His Tyr 
145                 150                 155                 160 


Leu Gln Val Ala Phe Pro Gly Ala Gly Asp Ala Asp Leu Val Pro Lys 
                165                 170                 175     


Leu Ser Arg Asn Tyr Leu Lys Glu Gly Tyr Met Glu Lys Xaa Gly Pro 
            180                 185                 190         


Lys Gln Xaa Glu Gly Phe Arg Lys Arg Trp Phe Xaa Met Asp Asp Arg 
        195                 200                 205             


Arg Leu Met Tyr Phe Lys Asp Pro Leu Asp Ala Phe Ala Arg Gly Glu 
    210                 215                 220                 


Val Phe Ile Gly Ser Lys Glu Ser Gly Tyr Xaa Val Leu His Gly Phe 
225                 230                 235                 240 


Pro Pro Ser Xaa Gln Gly His His Trp Pro His Gly Ile Xaa Ile Val 
                245                 250                 255     


Xaa Pro Asp Arg Lys Phe Leu Phe Ala Cys Glu Xaa Glu Ser Asp Gln 
            260                 265                 270         


Arg Glu Trp Val Ala Ala Phe Gln Lys Ala Val Asp Arg Pro Met Leu 
        275                 280                 285             


Pro Gln Glu Tyr Ala Val Glu Ala His Phe Lys His Lys Pro 
    290                 295                 300         


<210> 1537
<211> 385
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<400> 1537
Met Phe Gln Phe Val Phe Ser Arg Val Tyr Cys Ile Asn Pro Ala Arg 
1               5                   10                  15      


Arg Lys Trp Lys Glu Phe Glu Lys Met Leu Gly Cys Ala Glu Glu Gly 
            20                  25                  30          


His Ala Ser Leu Gly Arg Asp Pro Asp Trp Ala Ser Tyr Xaa Leu Gly 
        35                  40                  45              


Val Phe Ile Cys Leu Ser Cys Ser Gly Ile His Arg Asn Ile Pro Gln 
    50                  55                  60                  


Val Ser Lys Val Lys Ser Val Arg Leu Asp Ala Trp Glu Glu Ala Gln 
65                  70                  75                  80  


Val Glu Phe Met Ala Ser His Gly Asn Asp Ala Ala Arg Ala Arg Phe 
                85                  90                  95      


Glu Ser Lys Val Pro Ser Phe Tyr Tyr Arg Pro Xaa Pro Ser Asp Cys 
            100                 105                 110         


Gln Leu Leu Arg Glu Gln Trp Ile Arg Ala Lys Tyr Glu Arg Gln Glu 
        115                 120                 125             


Phe Ile Tyr Pro Glu Lys Gln Glu Pro Tyr Ser Ala Gly Tyr Arg Glu 
    130                 135                 140                 


Gly Phe Leu Trp Lys Arg Gly Arg Asp Asn Gly Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Lys Phe Val Leu Xaa Glu Arg Glu Gly Ala Leu Lys Tyr Phe Asn Arg 
                165                 170                 175     


Asn Asp Ala Lys Glu Pro Lys Ala Val Met Lys Ile Glu His Leu Asn 
            180                 185                 190         


Ala Xaa Phe Gln Pro Ala Lys Ile Gly His Pro His Gly Leu Gln Val 
        195                 200                 205             


Xaa Tyr Leu Lys Asp Asn Ser Xaa Arg Asn Ile Phe Ile Tyr His Glu 
    210                 215                 220                 


Asp Gly Lys Glu Ile Val Asp Trp Phe Asn Ala Leu Arg Ala Ala Arg 
225                 230                 235                 240 


Phe His Tyr Leu Gln Val Ala Phe Pro Gly Ala Gly Asp Ala Asp Leu 
                245                 250                 255     


Val Pro Lys Leu Ser Arg Asn Tyr Leu Lys Glu Gly Tyr Met Glu Lys 
            260                 265                 270         


Xaa Gly Pro Lys Gln Xaa Glu Gly Phe Arg Lys Arg Trp Phe Xaa Met 
        275                 280                 285             


Asp Asp Arg Arg Leu Met Tyr Phe Lys Asp Pro Leu Asp Ala Phe Ala 
    290                 295                 300                 


Arg Gly Glu Val Phe Ile Gly Ser Lys Glu Ser Gly Tyr Xaa Val Leu 
305                 310                 315                 320 


His Gly Phe Pro Pro Ser Xaa Gln Gly His His Trp Pro His Gly Ile 
                325                 330                 335     


Xaa Ile Val Xaa Pro Asp Arg Lys Phe Leu Phe Ala Cys Glu Xaa Glu 
            340                 345                 350         


Ser Asp Gln Arg Glu Trp Val Ala Ala Phe Gln Lys Ala Val Asp Arg 
        355                 360                 365             


Pro Met Leu Pro Gln Glu Tyr Ala Val Glu Ala His Phe Lys His Lys 
    370                 375                 380                 


Pro 
385 


<210> 1538
<211> 162
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<400> 1538
Met Leu Gly Cys Ala Glu Glu Gly His Ala Ser Leu Gly Arg Asp Pro 
1               5                   10                  15      


Asp Trp Ala Ser Tyr Xaa Leu Gly Val Phe Ile Cys Leu Ser Cys Ser 
            20                  25                  30          


Gly Ile His Arg Asn Ile Pro Gln Val Ser Lys Val Lys Ser Val Arg 
        35                  40                  45              


Leu Asp Ala Trp Glu Glu Ala Gln Val Glu Phe Met Ala Ser His Gly 
    50                  55                  60                  


Asn Asp Ala Ala Arg Ala Arg Phe Glu Ser Lys Val Pro Ser Phe Tyr 
65                  70                  75                  80  


Tyr Arg Pro Xaa Pro Ser Asp Cys Gln Leu Leu Arg Glu Gln Trp Ile 
                85                  90                  95      


Arg Ala Lys Tyr Glu Arg Gln Glu Phe Ile Tyr Pro Glu Lys Gln Glu 
            100                 105                 110         


Pro Tyr Ser Ala Gly Tyr Arg Glu Gly Phe Leu Trp Lys Arg Gly Arg 
        115                 120                 125             


Asp Asn Gly Gln Phe Leu Ser Arg Lys Phe Val Leu Xaa Glu Arg Glu 
    130                 135                 140                 


Gly Ala Leu Lys Tyr Phe Asn Arg Asn Asp Ala Lys Glu Pro Lys Ala 
145                 150                 155                 160 


Val Met 
        


<210> 1539
<211> 279
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<400> 1539
Met Val Leu Ala Ser Leu Glu Leu Leu Arg Glu Gln Trp Ile Arg Ala 
1               5                   10                  15      


Lys Tyr Glu Arg Gln Glu Phe Ile Tyr Pro Glu Lys Gln Glu Pro Tyr 
            20                  25                  30          


Ser Ala Gly Tyr Arg Glu Gly Phe Leu Trp Lys Arg Gly Arg Asp Asn 
        35                  40                  45              


Gly Gln Phe Leu Ser Arg Lys Phe Val Leu Xaa Glu Arg Glu Gly Ala 
    50                  55                  60                  


Leu Lys Tyr Phe Asn Arg Asn Asp Ala Lys Glu Pro Lys Ala Val Met 
65                  70                  75                  80  


Lys Ile Glu His Leu Asn Ala Xaa Phe Gln Pro Ala Lys Ile Gly His 
                85                  90                  95      


Pro His Gly Leu Gln Val Xaa Tyr Leu Lys Asp Asn Ser Xaa Arg Asn 
            100                 105                 110         


Ile Phe Ile Tyr His Glu Asp Gly Lys Glu Ile Val Asp Trp Phe Asn 
        115                 120                 125             


Ala Leu Arg Ala Ala Arg Phe His Tyr Leu Gln Val Ala Phe Pro Gly 
    130                 135                 140                 


Ala Gly Asp Ala Asp Leu Val Pro Lys Leu Ser Arg Asn Tyr Leu Lys 
145                 150                 155                 160 


Glu Gly Tyr Met Glu Lys Xaa Gly Pro Lys Gln Xaa Glu Gly Phe Arg 
                165                 170                 175     


Lys Arg Trp Phe Xaa Met Asp Asp Arg Arg Leu Met Tyr Phe Lys Asp 
            180                 185                 190         


Pro Leu Asp Ala Phe Ala Arg Gly Glu Val Phe Ile Gly Ser Lys Glu 
        195                 200                 205             


Ser Gly Tyr Xaa Val Leu His Gly Phe Pro Pro Ser Xaa Gln Gly His 
    210                 215                 220                 


His Trp Pro His Gly Ile Xaa Ile Val Xaa Pro Asp Arg Lys Phe Leu 
225                 230                 235                 240 


Phe Ala Cys Glu Xaa Glu Ser Asp Gln Arg Glu Trp Val Ala Ala Phe 
                245                 250                 255     


Gln Lys Ala Val Asp Arg Pro Met Leu Pro Gln Glu Tyr Ala Val Glu 
            260                 265                 270         


Ala His Phe Lys His Lys Pro 
        275                 


<210> 1540
<211> 192
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<400> 1540
Xaa Cys Arg Val Gln Pro Leu Cys Glu Gln Leu Gln Phe Met Ala Ser 
1               5                   10                  15      


His Gly Asn Asp Ala Ala Arg Ala Arg Phe Glu Ser Lys Val Pro Ser 
            20                  25                  30          


Phe Tyr Tyr Arg Pro Xaa Pro Ser Asp Cys Gln Leu Leu Arg Glu Gln 
        35                  40                  45              


Trp Ile Arg Ala Lys Tyr Glu Arg Gln Glu Phe Ile Tyr Pro Glu Lys 
    50                  55                  60                  


Gln Glu Pro Tyr Ser Ala Gly Tyr Arg Glu Gly Phe Leu Trp Lys Arg 
65                  70                  75                  80  


Gly Arg Asp Asn Gly Gln Phe Leu Ser Arg Lys Phe Val Leu Xaa Glu 
                85                  90                  95      


Arg Glu Gly Ala Leu Lys Tyr Phe Asn Arg Asn Asp Ala Lys Glu Pro 
            100                 105                 110         


Lys Ala Val Met Lys Ile Glu His Leu Asn Ala Xaa Phe Gln Pro Ala 
        115                 120                 125             


Lys Ile Gly His Pro His Gly Leu Gln Val Xaa Tyr Leu Lys Asp Asn 
    130                 135                 140                 


Ser Xaa Arg Asn Ile Phe Ile Tyr His Glu Asp Gly Lys Glu Ile Val 
145                 150                 155                 160 


Asp Trp Phe Asn Ala Leu Arg Ala Ala Arg Phe His Tyr Leu Gln Val 
                165                 170                 175     


Ala Phe Pro Gly Ala Gly Asp Ala Asp Leu Val Pro Lys Leu Ser Arg 
            180                 185                 190         


<210> 1541
<211> 187
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 1541
Xaa Gly Cys Gly Leu Arg Arg Val Val Phe Arg Ser Leu Lys Phe Met 
1               5                   10                  15      


Ala Ser His Gly Asn Asp Ala Ala Arg Ala Arg Phe Glu Ser Lys Val 
            20                  25                  30          


Pro Ser Phe Tyr Tyr Arg Pro Xaa Pro Ser Asp Cys Gln Leu Leu Arg 
        35                  40                  45              


Glu Gln Trp Ile Arg Ala Lys Tyr Glu Arg Gln Glu Phe Ile Tyr Pro 
    50                  55                  60                  


Glu Lys Gln Glu Pro Tyr Ser Ala Gly Tyr Arg Glu Gly Phe Leu Trp 
65                  70                  75                  80  


Lys Arg Gly Arg Asp Asn Gly Gln Phe Leu Ser Arg Lys Phe Val Leu 
                85                  90                  95      


Xaa Glu Arg Glu Gly Ala Leu Lys Tyr Phe Asn Arg Asn Asp Ala Lys 
            100                 105                 110         


Glu Pro Lys Ala Val Met Lys Ile Glu His Leu Asn Ala Xaa Phe Gln 
        115                 120                 125             


Pro Ala Lys Ile Gly His Pro His Gly Leu Gln Val Xaa Tyr Leu Lys 
    130                 135                 140                 


Asp Asn Ser Xaa Arg Asn Ile Phe Ile Tyr His Glu Asp Gly Lys Glu 
145                 150                 155                 160 


Ile Val Asp Trp Phe Asn Ala Leu Arg Ala Ala Arg Phe His Tyr Leu 
                165                 170                 175     


Gln Val Ala Phe Pro Gly Ala Gly Asp Ala Asp 
            180                 185         


<210> 1542
<211> 207
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<400> 1542
Xaa Asn Ser Leu Gly Val Glu Lys Ala Gly Ala Ala Ala Cys Ala Pro 
1               5                   10                  15      


Gly Pro Cys Arg Ala Cys Val Trp Val Val Val Ser Ala Met Val Leu 
            20                  25                  30          


Ala Ser Leu Glu Leu Leu Arg Glu Gln Trp Ile Arg Ala Lys Tyr Glu 
        35                  40                  45              


Arg Gln Glu Phe Ile Tyr Pro Glu Lys Gln Glu Pro Tyr Ser Ala Gly 
    50                  55                  60                  


Tyr Arg Glu Gly Phe Leu Trp Lys Arg Gly Arg Asp Asn Gly Gln Phe 
65                  70                  75                  80  


Leu Ser Arg Lys Phe Val Leu Xaa Glu Arg Glu Gly Ala Leu Lys Tyr 
                85                  90                  95      


Phe Asn Arg Asn Asp Ala Lys Glu Pro Lys Ala Val Met Lys Ile Glu 
            100                 105                 110         


His Leu Asn Ala Xaa Phe Gln Pro Ala Lys Ile Gly His Pro His Gly 
        115                 120                 125             


Leu Gln Val Xaa Tyr Leu Lys Asp Asn Ser Xaa Arg Asn Ile Phe Ile 
    130                 135                 140                 


Tyr His Glu Asp Gly Lys Glu Ile Val Asp Trp Phe Asn Ala Leu Arg 
145                 150                 155                 160 


Ala Ala Arg Phe His Tyr Leu Gln Val Ala Phe Pro Gly Ala Gly Asp 
                165                 170                 175     


Ala Asp Leu Val Pro Lys Leu Ser Arg Asn Tyr Leu Lys Glu Gly Tyr 
            180                 185                 190         


Met Glu Lys Xaa Gly Pro Lys Gln Xaa Glu Gly Phe Arg Lys Arg 
        195                 200                 205         


<210> 1543
<211> 357
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<400> 1543
Xaa Ser Phe Ser Leu Ser Leu Phe Arg Lys His Val Leu Gly Pro Cys 
1               5                   10                  15      


Ser Val Ser Leu Gln Ser Pro Leu Arg Asp Ser Val Leu Ala Xaa Ser 
            20                  25                  30          


Gly Ser Leu Ala His Gln Pro Ile Ser Arg Pro Pro Cys Leu Ala Pro 
        35                  40                  45              


Val Gly Ser Leu Leu Asn Phe Met Ala Ser His Gly Asn Asp Ala Ala 
    50                  55                  60                  


Arg Ala Arg Phe Glu Ser Lys Val Pro Ser Phe Tyr Tyr Arg Pro Xaa 
65                  70                  75                  80  


Pro Ser Asp Cys Gln Leu Leu Arg Glu Gln Trp Ile Arg Ala Lys Tyr 
                85                  90                  95      


Glu Arg Gln Glu Phe Ile Tyr Pro Glu Lys Gln Glu Pro Tyr Ser Ala 
            100                 105                 110         


Gly Tyr Arg Glu Gly Phe Leu Trp Lys Arg Gly Arg Asp Asn Gly Gln 
        115                 120                 125             


Phe Leu Ser Arg Lys Phe Val Leu Xaa Glu Arg Glu Gly Ala Leu Lys 
    130                 135                 140                 


Tyr Phe Asn Arg Asn Asp Ala Lys Glu Pro Lys Ala Val Met Lys Ile 
145                 150                 155                 160 


Glu His Leu Asn Ala Xaa Phe Gln Pro Ala Lys Ile Gly His Pro His 
                165                 170                 175     


Gly Leu Gln Val Xaa Tyr Leu Lys Asp Asn Ser Xaa Arg Asn Ile Phe 
            180                 185                 190         


Ile Tyr His Glu Asp Gly Lys Glu Ile Val Asp Trp Phe Asn Ala Leu 
        195                 200                 205             


Arg Ala Ala Arg Phe His Tyr Leu Gln Val Ala Phe Pro Gly Ala Gly 
    210                 215                 220                 


Asp Ala Asp Leu Val Pro Lys Leu Ser Arg Asn Tyr Leu Lys Glu Gly 
225                 230                 235                 240 


Tyr Met Glu Lys Xaa Gly Pro Lys Gln Xaa Glu Gly Phe Arg Lys Arg 
                245                 250                 255     


Trp Phe Xaa Met Asp Asp Arg Arg Leu Met Tyr Phe Lys Asp Pro Leu 
            260                 265                 270         


Asp Ala Phe Ala Arg Gly Glu Val Phe Ile Gly Ser Lys Glu Ser Gly 
        275                 280                 285             


Tyr Xaa Val Leu His Gly Phe Pro Pro Ser Xaa Gln Gly His His Trp 
    290                 295                 300                 


Pro His Gly Ile Xaa Ile Val Xaa Pro Asp Arg Lys Phe Leu Phe Ala 
305                 310                 315                 320 


Cys Glu Xaa Glu Ser Asp Gln Arg Glu Trp Val Ala Ala Phe Gln Lys 
                325                 330                 335     


Ala Val Asp Arg Pro Met Leu Pro Gln Glu Tyr Ala Val Glu Ala His 
            340                 345                 350         


Phe Lys His Lys Pro 
        355         


<210> 1544
<211> 245
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<400> 1544
Tyr Phe Asn Arg Asn Asp Ala Lys Glu Pro Lys Ala Val Met Lys Ile 
1               5                   10                  15      


Glu His Leu Asn Ala Xaa Phe Gln Pro Ala Lys Ile Gly His Pro His 
            20                  25                  30          


Gly Leu Gln Val Xaa Tyr Leu Lys Asp Asn Ser Xaa Arg Asn Ile Phe 
        35                  40                  45              


Ile Tyr His Glu Asp Gly Lys Xaa Cys Leu Ser Tyr Lys Ile Arg Ile 
    50                  55                  60                  


Phe Ile Lys Ile Ala Pro Ser Glu Arg Lys Ala Ser Trp Pro Arg Pro 
65                  70                  75                  80  


Gln Gln His Gln Gly His Arg Glu Ile Val Asp Trp Phe Asn Ala Leu 
                85                  90                  95      


Arg Ala Ala Arg Phe His Tyr Leu Gln Val Ala Phe Pro Gly Ala Gly 
            100                 105                 110         


Asp Ala Asp Leu Val Pro Lys Leu Ser Arg Asn Tyr Leu Lys Glu Gly 
        115                 120                 125             


Tyr Met Glu Lys Xaa Gly Pro Lys Gln Xaa Glu Gly Phe Arg Lys Arg 
    130                 135                 140                 


Trp Phe Xaa Met Asp Asp Arg Arg Leu Met Tyr Phe Lys Asp Pro Leu 
145                 150                 155                 160 


Asp Ala Phe Ala Arg Gly Glu Val Phe Ile Gly Ser Lys Glu Ser Gly 
                165                 170                 175     


Tyr Xaa Val Leu His Gly Phe Pro Pro Ser Xaa Gln Gly His His Trp 
            180                 185                 190         


Pro His Gly Ile Xaa Ile Val Xaa Pro Asp Arg Lys Phe Leu Phe Ala 
        195                 200                 205             


Cys Glu Xaa Glu Ser Asp Gln Arg Glu Trp Val Ala Ala Phe Gln Lys 
    210                 215                 220                 


Ala Val Asp Arg Pro Met Leu Pro Gln Glu Tyr Ala Val Glu Ala His 
225                 230                 235                 240 


Phe Lys His Lys Pro 
                245 


<210> 1545
<211> 1195
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1093)..(1093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<400> 1545
Gly Tyr Ser Leu Ser Gly Tyr Tyr Xaa His Pro Phe Gln Gly Tyr Glu 
1               5                   10                  15      


His Arg Gln Leu Arg Tyr Gln Gln Pro Gly Pro Gly Ser Ser Pro Ser 
            20                  25                  30          


Ser Phe Leu Leu Lys Gln Ile Glu Phe Leu Lys Gly Gln Leu Pro Glu 
        35                  40                  45              


Ala Pro Val Ile Gly Lys Gln Xaa Pro Ser Leu Pro Pro Ser Leu Pro 
    50                  55                  60                  


Gly Leu Arg Pro Arg Phe Pro Val Leu Leu Ala Ser Ser Xaa Arg Gly 
65                  70                  75                  80  


Arg Gln Val Asp Ile Arg Gly Val Pro Arg Gly Val His Leu Arg Ser 
                85                  90                  95      


Gln Gly Leu Gln Arg Gly Phe Gln His Pro Ser Pro Arg Gly Arg Ser 
            100                 105                 110         


Leu Pro Gln Arg Gly Val Asp Cys Leu Ser Ser His Phe Gln Glu Leu 
        115                 120                 125             


Ser Ile Tyr Gln Asp Gln Glu Gln Arg Ile Leu Lys Phe Leu Glu Glu 
    130                 135                 140                 


Leu Gly Glu Gly Lys Ala Xaa Xaa Ala His Asp Leu Ser Gly Lys Leu 
145                 150                 155                 160 


Gly Xaa Pro Lys Lys Glu Ile Asn Arg Val Leu Tyr Ser Leu Ala Lys 
                165                 170                 175     


Lys Gly Lys Leu Gln Lys Glu Ala Gly Xaa Pro Pro Leu Trp Lys Ile 
            180                 185                 190         


Ala Val Ser Xaa Gln Ala Trp Asn Gln His Ser Gly Val Val Arg Pro 
        195                 200                 205             


Asp Gly His Ser Gln Gly Ala Pro Asn Ser Asp Pro Ser Leu Glu Pro 
    210                 215                 220                 


Glu Asp Arg Asn Ser Xaa Ser Val Ser Glu Asp Leu Leu Glu Pro Phe 
225                 230                 235                 240 


Ile Ala Val Ser Ala Gln Ala Trp Asn Gln His Ser Gly Val Val Arg 
                245                 250                 255     


Pro Asp Ser His Ser Gln Gly Ser Pro Asn Ser Asp Pro Gly Leu Glu 
            260                 265                 270         


Pro Glu Asp Ser Asn Ser Xaa Ser Ala Leu Glu Asp Pro Leu Glu Phe 
        275                 280                 285             


Leu Asp Met Ala Glu Ile Lys Glu Lys Ile Cys Asp Tyr Leu Phe Asn 
    290                 295                 300                 


Val Ser Asp Ser Ser Ala Leu Asn Leu Ala Lys Asn Ile Gly Leu Xaa 
305                 310                 315                 320 


Lys Ala Arg Asp Ile Asn Ala Val Leu Ile Asp Met Glu Arg Gln Gly 
                325                 330                 335     


Asp Val Tyr Arg Gln Gly Xaa Xaa Pro Pro Ile Trp His Leu Xaa Asp 
            340                 345                 350         


Lys Lys Arg Glu Arg Met Gln Ile Lys Arg Asn Xaa Asn Ser Val Pro 
        355                 360                 365             


Glu Xaa Ala Pro Ala Ala Ile Pro Glu Xaa Lys Arg Asn Ala Glu Phe 
    370                 375                 380                 


Leu Xaa Cys Asn Ile Pro Xaa Ser Asn Ala Ser Asn Asn Met Val Xaa 
385                 390                 395                 400 


Xaa Glu Lys Val Glu Asn Gly Gln Glu Pro Val Ile Lys Leu Glu Asn 
                405                 410                 415     


Arg Gln Glu Ala Arg Pro Glu Pro Ala Arg Leu Lys Pro Pro Val His 
            420                 425                 430         


Tyr Asn Gly Pro Ser Lys Ala Gly Tyr Val Asp Phe Glu Asn Gly Gln 
        435                 440                 445             


Trp Ala Xaa Asp Asp Ile Pro Asp Asp Leu Asn Ser Ile Arg Ala Ala 
    450                 455                 460                 


Pro Gly Glu Phe Arg Ala Ile Met Glu Met Pro Ser Phe Tyr Ser His 
465                 470                 475                 480 


Gly Leu Pro Arg Cys Ser Pro Tyr Lys Lys Leu Xaa Glu Cys Gln Leu 
                485                 490                 495     


Lys Asn Pro Ile Ser Gly Leu Leu Glu Tyr Ala Gln Phe Ala Ser Gln 
            500                 505                 510         


Xaa Cys Glu Phe Asn Met Ile Glu Gln Ser Gly Pro Pro His Glu Pro 
        515                 520                 525             


Arg Phe Lys Phe Gln Val Val Ile Asn Gly Arg Glu Phe Pro Pro Ala 
    530                 535                 540                 


Glu Ala Gly Ser Lys Lys Val Ala Lys Gln Asp Ala Ala Met Lys Ala 
545                 550                 555                 560 


Met Xaa Ile Leu Leu Glu Glu Ala Lys Ala Lys Asp Ser Gly Lys Ser 
                565                 570                 575     


Glu Glu Ser Ser His Tyr Ser Xaa Glu Lys Glu Ser Glu Lys Xaa Ala 
            580                 585                 590         


Glu Ser Gln Xaa Pro Xaa Pro Ser Ala Xaa Ser Phe Phe Ser Gly Lys 
        595                 600                 605             


Ser Pro Val Xaa Xaa Leu Leu Glu Cys Met His Lys Leu Gly Asn Ser 
    610                 615                 620                 


Cys Glu Phe Arg Leu Leu Ser Lys Glu Gly Pro Ala His Glu Pro Lys 
625                 630                 635                 640 


Phe Gln Tyr Cys Val Ala Val Gly Ala Gln Xaa Phe Pro Ser Val Ser 
                645                 650                 655     


Ala Pro Ser Lys Lys Val Ala Lys Gln Met Ala Ala Glu Glu Ala Met 
            660                 665                 670         


Lys Ala Leu His Gly Glu Ala Xaa Asn Ser Met Ala Ser Asp Asn Gln 
        675                 680                 685             


Pro Glu Gly Met Ile Ser Glu Ser Leu Asp Asn Leu Glu Ser Met Met 
    690                 695                 700                 


Pro Asn Lys Val Arg Lys Ile Gly Glu Leu Val Arg Tyr Leu Asn Xaa 
705                 710                 715                 720 


Asn Pro Val Gly Gly Leu Leu Glu Tyr Ala Arg Ser His Gly Phe Ala 
                725                 730                 735     


Ala Glu Phe Lys Leu Val Asp Gln Ser Gly Pro Pro His Glu Pro Lys 
            740                 745                 750         


Phe Val Tyr Gln Ala Lys Val Gly Gly Arg Trp Phe Pro Ala Val Cys 
        755                 760                 765             


Ala His Ser Lys Lys Gln Gly Lys Gln Glu Ala Ala Asp Ala Ala Leu 
    770                 775                 780                 


Arg Val Leu Ile Gly Glu Asn Glu Lys Ala Glu Arg Met Gly Phe Xaa 
785                 790                 795                 800 


Glu Leu Pro Leu Xaa Gly Ser Xaa Phe His Asp Gln Ile Ala Met Leu 
                805                 810                 815     


Ser His Arg Cys Phe Asn Xaa Leu Xaa Asn Ser Phe Gln Pro Ser Leu 
            820                 825                 830         


Leu Gly Arg Lys Ile Leu Ala Ala Ile Ile Met Lys Lys Asp Ser Glu 
        835                 840                 845             


Asp Met Gly Val Val Val Ser Leu Gly Xaa Gly Asn Arg Cys Val Lys 
    850                 855                 860                 


Gly Asp Ser Leu Ser Leu Lys Gly Glu Xaa Val Asn Asp Cys His Ala 
865                 870                 875                 880 


Glu Ile Ile Ser Arg Arg Gly Phe Ile Arg Phe Leu Tyr Ser Glu Leu 
                885                 890                 895     


Met Lys Tyr Asn Ser Gln Xaa Ala Lys Asp Ser Ile Phe Glu Pro Ala 
            900                 905                 910         


Lys Gly Gly Glu Lys Leu Gln Ile Lys Lys Xaa Val Ser Phe His Leu 
        915                 920                 925             


Tyr Ile Ser Xaa Ala Pro Cys Gly Asp Gly Ala Leu Phe Asp Lys Ser 
    930                 935                 940                 


Cys Ser Asp Arg Ala Met Glu Ser Xaa Glu Ser Arg His Tyr Pro Val 
945                 950                 955                 960 


Phe Glu Asn Pro Lys Gln Gly Lys Leu Arg Xaa Lys Val Glu Asn Gly 
                965                 970                 975     


Glu Gly Xaa Ile Pro Val Glu Ser Ser Asp Ile Val Pro Xaa Trp Asp 
            980                 985                 990         


Gly Ile Arg Leu Gly Glu Arg Leu  Arg Xaa Met Ser Cys  Ser Asp Lys 
        995                 1000                 1005             


Ile Leu  Arg Trp Asn Val Leu  Gly Leu Gln Gly Ala  Leu Leu Xaa 
    1010                 1015                 1020             


His Phe  Leu Gln Pro Ile Tyr  Leu Lys Ser Val Xaa  Leu Gly Tyr 
    1025                 1030                 1035             


Leu Phe  Ser Gln Gly His Leu  Xaa Arg Ala Ile Cys  Cys Arg Val 
    1040                 1045                 1050             


Xaa Arg  Asp Gly Ser Ala Phe  Glu Asp Gly Leu Arg  His Pro Phe 
    1055                 1060                 1065             


Ile Val  Asn His Pro Lys Val  Gly Arg Val Ser Ile  Tyr Asp Ser 
    1070                 1075                 1080             


Lys Arg  Gln Ser Gly Lys Xaa  Lys Glu Xaa Ser Val  Asn Trp Cys 
    1085                 1090                 1095             


Leu Ala  Asp Gly Tyr Asp Leu  Glu Ile Leu Asp Gly  Xaa Arg Gly 
    1100                 1105                 1110             


Xaa Val  Asp Gly Pro Arg Asn  Glu Leu Ser Arg Val  Ser Lys Lys 
    1115                 1120                 1125             


Asn Ile  Phe Leu Leu Phe Lys  Lys Leu Cys Ser Phe  Arg Tyr Arg 
    1130                 1135                 1140             


Arg Asp  Leu Leu Arg Leu Ser  Tyr Gly Glu Ala Lys  Lys Ala Ala 
    1145                 1150                 1155             


Arg Asp  Tyr Glu Xaa Ala Lys  Asn Tyr Phe Lys Lys  Gly Leu Lys 
    1160                 1165                 1170             


Asp Met  Gly Tyr Gly Asn Trp  Ile Ser Lys Pro Gln  Glu Glu Lys 
    1175                 1180                 1185             


Asn Phe  Tyr Leu Cys Pro Val  
    1190                 1195 


<210> 1546
<211> 931
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<400> 1546
Met Ala Glu Ile Lys Glu Lys Ile Cys Asp Tyr Leu Phe Asn Val Ser 
1               5                   10                  15      


Asp Ser Ser Ala Leu Asn Leu Ala Lys Asn Ile Gly Leu Xaa Lys Ala 
            20                  25                  30          


Arg Asp Ile Asn Ala Val Leu Ile Asp Met Glu Arg Gln Gly Asp Val 
        35                  40                  45              


Tyr Arg Gln Gly Xaa Xaa Pro Pro Ile Trp His Leu Xaa Asp Lys Lys 
    50                  55                  60                  


Arg Glu Arg Met Gln Ile Lys Arg Asn Xaa Asn Ser Val Pro Glu Xaa 
65                  70                  75                  80  


Ala Pro Ala Ala Ile Pro Glu Xaa Lys Arg Asn Ala Glu Phe Leu Xaa 
                85                  90                  95      


Cys Asn Ile Pro Xaa Ser Asn Ala Ser Asn Asn Met Val Xaa Xaa Glu 
            100                 105                 110         


Lys Val Glu Asn Gly Gln Glu Pro Val Ile Lys Leu Glu Asn Arg Gln 
        115                 120                 125             


Glu Ala Arg Pro Glu Pro Ala Arg Leu Lys Pro Pro Val His Tyr Asn 
    130                 135                 140                 


Gly Pro Ser Lys Ala Gly Tyr Val Asp Phe Glu Asn Gly Gln Trp Ala 
145                 150                 155                 160 


Xaa Asp Asp Ile Pro Asp Asp Leu Asn Ser Ile Arg Ala Ala Pro Gly 
                165                 170                 175     


Glu Phe Arg Ala Ile Met Glu Met Pro Ser Phe Tyr Ser His Gly Leu 
            180                 185                 190         


Pro Arg Cys Ser Pro Tyr Lys Lys Leu Xaa Glu Cys Gln Leu Lys Asn 
        195                 200                 205             


Pro Ile Ser Gly Leu Leu Glu Tyr Ala Gln Phe Ala Ser Gln Xaa Cys 
    210                 215                 220                 


Glu Phe Asn Met Ile Glu Gln Ser Gly Pro Pro His Glu Pro Arg Phe 
225                 230                 235                 240 


Lys Phe Gln Val Val Ile Asn Gly Arg Glu Phe Pro Pro Ala Glu Ala 
                245                 250                 255     


Gly Ser Lys Lys Val Ala Lys Gln Asp Ala Ala Met Lys Ala Met Xaa 
            260                 265                 270         


Ile Leu Leu Glu Glu Ala Lys Ala Lys Asp Ser Gly Lys Ser Glu Glu 
        275                 280                 285             


Ser Ser His Tyr Ser Xaa Glu Lys Glu Ser Glu Lys Xaa Ala Glu Ser 
    290                 295                 300                 


Gln Xaa Pro Xaa Pro Ser Ala Xaa Ser Phe Phe Ser Gly Lys Ser Pro 
305                 310                 315                 320 


Val Xaa Xaa Leu Leu Glu Cys Met His Lys Leu Gly Asn Ser Cys Glu 
                325                 330                 335     


Phe Arg Leu Leu Ser Lys Glu Gly Pro Ala His Glu Pro Lys Phe Gln 
            340                 345                 350         


Tyr Cys Val Ala Val Gly Ala Gln Xaa Phe Pro Ser Val Ser Ala Pro 
        355                 360                 365             


Ser Lys Lys Val Ala Lys Gln Met Ala Ala Glu Glu Ala Met Lys Ala 
    370                 375                 380                 


Leu His Gly Glu Ala Xaa Asn Ser Met Ala Ser Asp Asn Gln Pro Glu 
385                 390                 395                 400 


Gly Met Ile Ser Glu Ser Leu Asp Asn Leu Glu Ser Met Met Pro Asn 
                405                 410                 415     


Lys Val Arg Lys Ile Gly Glu Leu Val Arg Tyr Leu Asn Xaa Asn Pro 
            420                 425                 430         


Val Gly Gly Leu Leu Glu Tyr Ala Arg Ser His Gly Phe Ala Ala Glu 
        435                 440                 445             


Phe Lys Leu Val Asp Gln Ser Gly Pro Pro His Glu Pro Lys Phe Val 
    450                 455                 460                 


Tyr Gln Ala Lys Val Gly Gly Arg Trp Phe Pro Ala Val Cys Ala His 
465                 470                 475                 480 


Ser Lys Lys Gln Gly Lys Gln Glu Ala Ala Asp Ala Ala Leu Arg Val 
                485                 490                 495     


Leu Ile Gly Glu Asn Glu Lys Ala Glu Arg Met Gly Phe Xaa Glu Val 
            500                 505                 510         


Xaa Pro Val Xaa Gly Ala Ser Leu Arg Arg Xaa Met Leu Leu Leu Ser 
        515                 520                 525             


Arg Ser Pro Glu Ala Gln Pro Lys Xaa Leu Pro Leu Xaa Gly Ser Xaa 
    530                 535                 540                 


Phe His Asp Gln Ile Ala Met Leu Ser His Arg Cys Phe Asn Xaa Leu 
545                 550                 555                 560 


Xaa Asn Ser Phe Gln Pro Ser Leu Leu Gly Arg Lys Ile Leu Ala Ala 
                565                 570                 575     


Ile Ile Met Lys Lys Asp Ser Glu Asp Met Gly Val Val Val Ser Leu 
            580                 585                 590         


Gly Xaa Gly Asn Arg Cys Val Lys Gly Asp Ser Leu Ser Leu Lys Gly 
        595                 600                 605             


Glu Xaa Val Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg Gly Phe 
    610                 615                 620                 


Ile Arg Phe Leu Tyr Ser Glu Leu Met Lys Tyr Asn Ser Gln Xaa Ala 
625                 630                 635                 640 


Lys Asp Ser Ile Phe Glu Pro Ala Lys Gly Gly Glu Lys Leu Gln Ile 
                645                 650                 655     


Lys Lys Xaa Val Ser Phe His Leu Tyr Ile Ser Xaa Ala Pro Cys Gly 
            660                 665                 670         


Asp Gly Ala Leu Phe Asp Lys Ser Cys Ser Asp Arg Ala Met Glu Ser 
        675                 680                 685             


Xaa Glu Ser Arg His Tyr Pro Val Phe Glu Asn Pro Lys Gln Gly Lys 
    690                 695                 700                 


Leu Arg Xaa Lys Val Glu Asn Gly Glu Gly Xaa Ile Pro Val Glu Ser 
705                 710                 715                 720 


Ser Asp Ile Val Pro Xaa Trp Asp Gly Ile Arg Leu Gly Glu Arg Leu 
                725                 730                 735     


Arg Xaa Met Ser Cys Ser Asp Lys Ile Leu Arg Trp Asn Val Leu Gly 
            740                 745                 750         


Leu Gln Gly Ala Leu Leu Xaa His Phe Leu Gln Pro Ile Tyr Leu Lys 
        755                 760                 765             


Ser Val Xaa Leu Gly Tyr Leu Phe Ser Gln Gly His Leu Xaa Arg Ala 
    770                 775                 780                 


Ile Cys Cys Arg Val Xaa Arg Asp Gly Ser Ala Phe Glu Asp Gly Leu 
785                 790                 795                 800 


Arg His Pro Phe Ile Val Asn His Pro Lys Val Gly Arg Val Ser Ile 
                805                 810                 815     


Tyr Asp Ser Lys Arg Gln Ser Gly Lys Xaa Lys Glu Xaa Ser Val Asn 
            820                 825                 830         


Trp Cys Leu Ala Asp Gly Tyr Asp Leu Glu Ile Leu Asp Gly Xaa Arg 
        835                 840                 845             


Gly Xaa Val Asp Gly Pro Arg Asn Glu Leu Ser Arg Val Ser Lys Lys 
    850                 855                 860                 


Asn Ile Phe Leu Leu Phe Lys Lys Leu Cys Ser Phe Arg Tyr Arg Arg 
865                 870                 875                 880 


Asp Leu Leu Arg Leu Ser Tyr Gly Glu Ala Lys Lys Ala Ala Arg Asp 
                885                 890                 895     


Tyr Glu Xaa Ala Lys Asn Tyr Phe Lys Lys Gly Leu Lys Asp Met Gly 
            900                 905                 910         


Tyr Gly Asn Trp Ile Ser Lys Pro Gln Glu Glu Lys Asn Phe Tyr Leu 
        915                 920                 925             


Cys Pro Val 
    930     


<210> 1547
<211> 1226
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1066)..(1066)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1145)..(1145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<400> 1547
Met Asn Pro Arg Gln Gly Tyr Ser Leu Ser Gly Tyr Tyr Xaa His Pro 
1               5                   10                  15      


Phe Gln Gly Tyr Glu His Arg Gln Leu Arg Tyr Gln Gln Pro Gly Pro 
            20                  25                  30          


Gly Ser Ser Pro Ser Ser Phe Leu Leu Lys Gln Ile Glu Phe Leu Lys 
        35                  40                  45              


Gly Gln Leu Pro Glu Ala Pro Val Ile Gly Lys Gln Xaa Pro Ser Leu 
    50                  55                  60                  


Pro Pro Ser Leu Pro Gly Leu Arg Pro Arg Phe Pro Val Leu Leu Ala 
65                  70                  75                  80  


Ser Ser Xaa Arg Gly Arg Gln Val Asp Ile Arg Gly Val Pro Arg Gly 
                85                  90                  95      


Val His Leu Arg Ser Gln Gly Leu Gln Arg Gly Phe Gln His Pro Ser 
            100                 105                 110         


Pro Arg Gly Arg Ser Leu Pro Gln Arg Gly Val Asp Cys Leu Ser Ser 
        115                 120                 125             


His Phe Gln Glu Leu Ser Ile Tyr Gln Asp Gln Glu Gln Arg Ile Leu 
    130                 135                 140                 


Lys Phe Leu Glu Glu Leu Gly Glu Gly Lys Ala Xaa Xaa Ala His Asp 
145                 150                 155                 160 


Leu Ser Gly Lys Leu Gly Xaa Pro Lys Lys Glu Ile Asn Arg Val Leu 
                165                 170                 175     


Tyr Ser Leu Ala Lys Lys Gly Lys Leu Gln Lys Glu Ala Gly Xaa Pro 
            180                 185                 190         


Pro Leu Trp Lys Ile Ala Val Ser Xaa Gln Ala Trp Asn Gln His Ser 
        195                 200                 205             


Gly Val Val Arg Pro Asp Gly His Ser Gln Gly Ala Pro Asn Ser Asp 
    210                 215                 220                 


Pro Ser Leu Glu Pro Glu Asp Arg Asn Ser Xaa Ser Val Ser Glu Asp 
225                 230                 235                 240 


Leu Leu Glu Pro Phe Ile Ala Val Ser Ala Gln Ala Trp Asn Gln His 
                245                 250                 255     


Ser Gly Val Val Arg Pro Asp Ser His Ser Gln Gly Ser Pro Asn Ser 
            260                 265                 270         


Asp Pro Gly Leu Glu Pro Glu Asp Ser Asn Ser Xaa Ser Ala Leu Glu 
        275                 280                 285             


Asp Pro Leu Glu Phe Leu Asp Met Ala Glu Ile Lys Glu Lys Ile Cys 
    290                 295                 300                 


Asp Tyr Leu Phe Asn Val Ser Asp Ser Ser Ala Leu Asn Leu Ala Lys 
305                 310                 315                 320 


Asn Ile Gly Leu Xaa Lys Ala Arg Asp Ile Asn Ala Val Leu Ile Asp 
                325                 330                 335     


Met Glu Arg Gln Gly Asp Val Tyr Arg Gln Gly Xaa Xaa Pro Pro Ile 
            340                 345                 350         


Trp His Leu Xaa Asp Lys Lys Arg Glu Arg Met Gln Ile Lys Arg Asn 
        355                 360                 365             


Xaa Asn Ser Val Pro Glu Xaa Ala Pro Ala Ala Ile Pro Glu Xaa Lys 
    370                 375                 380                 


Arg Asn Ala Glu Phe Leu Xaa Cys Asn Ile Pro Xaa Ser Asn Ala Ser 
385                 390                 395                 400 


Asn Asn Met Val Xaa Xaa Glu Lys Val Glu Asn Gly Gln Glu Pro Val 
                405                 410                 415     


Ile Lys Leu Glu Asn Arg Gln Glu Ala Arg Pro Glu Pro Ala Arg Leu 
            420                 425                 430         


Lys Pro Pro Val His Tyr Asn Gly Pro Ser Lys Ala Gly Tyr Val Asp 
        435                 440                 445             


Phe Glu Asn Gly Gln Trp Ala Xaa Asp Asp Ile Pro Asp Asp Leu Asn 
    450                 455                 460                 


Ser Ile Arg Ala Ala Pro Gly Glu Phe Arg Ala Ile Met Glu Met Pro 
465                 470                 475                 480 


Ser Phe Tyr Ser His Gly Leu Pro Arg Cys Ser Pro Tyr Lys Lys Leu 
                485                 490                 495     


Xaa Glu Cys Gln Leu Lys Asn Pro Ile Ser Gly Leu Leu Glu Tyr Ala 
            500                 505                 510         


Gln Phe Ala Ser Gln Xaa Cys Glu Phe Asn Met Ile Glu Gln Ser Gly 
        515                 520                 525             


Pro Pro His Glu Pro Arg Phe Lys Phe Gln Val Val Ile Asn Gly Arg 
    530                 535                 540                 


Glu Phe Pro Pro Ala Glu Ala Gly Ser Lys Lys Val Ala Lys Gln Asp 
545                 550                 555                 560 


Ala Ala Met Lys Ala Met Xaa Ile Leu Leu Glu Glu Ala Lys Ala Lys 
                565                 570                 575     


Asp Ser Gly Lys Ser Glu Glu Ser Ser His Tyr Ser Xaa Glu Lys Glu 
            580                 585                 590         


Ser Glu Lys Xaa Ala Glu Ser Gln Xaa Pro Xaa Pro Ser Ala Xaa Ser 
        595                 600                 605             


Phe Phe Ser Gly Lys Ser Pro Val Xaa Xaa Leu Leu Glu Cys Met His 
    610                 615                 620                 


Lys Leu Gly Asn Ser Cys Glu Phe Arg Leu Leu Ser Lys Glu Gly Pro 
625                 630                 635                 640 


Ala His Glu Pro Lys Phe Gln Tyr Cys Val Ala Val Gly Ala Gln Xaa 
                645                 650                 655     


Phe Pro Ser Val Ser Ala Pro Ser Lys Lys Val Ala Lys Gln Met Ala 
            660                 665                 670         


Ala Glu Glu Ala Met Lys Ala Leu His Gly Glu Ala Xaa Asn Ser Met 
        675                 680                 685             


Ala Ser Asp Asn Gln Pro Glu Gly Met Ile Ser Glu Ser Leu Asp Asn 
    690                 695                 700                 


Leu Glu Ser Met Met Pro Asn Lys Val Arg Lys Ile Gly Glu Leu Val 
705                 710                 715                 720 


Arg Tyr Leu Asn Xaa Asn Pro Val Gly Gly Leu Leu Glu Tyr Ala Arg 
                725                 730                 735     


Ser His Gly Phe Ala Ala Glu Phe Lys Leu Val Asp Gln Ser Gly Pro 
            740                 745                 750         


Pro His Glu Pro Lys Phe Val Tyr Gln Ala Lys Val Gly Gly Arg Trp 
        755                 760                 765             


Phe Pro Ala Val Cys Ala His Ser Lys Lys Gln Gly Lys Gln Glu Ala 
    770                 775                 780                 


Ala Asp Ala Ala Leu Arg Val Leu Ile Gly Glu Asn Glu Lys Ala Glu 
785                 790                 795                 800 


Arg Met Gly Phe Xaa Glu Val Xaa Pro Val Xaa Gly Ala Ser Leu Arg 
                805                 810                 815     


Arg Xaa Met Leu Leu Leu Ser Arg Ser Pro Glu Ala Gln Pro Lys Xaa 
            820                 825                 830         


Leu Pro Leu Xaa Gly Ser Xaa Phe His Asp Gln Ile Ala Met Leu Ser 
        835                 840                 845             


His Arg Cys Phe Asn Xaa Leu Xaa Asn Ser Phe Gln Pro Ser Leu Leu 
    850                 855                 860                 


Gly Arg Lys Ile Leu Ala Ala Ile Ile Met Lys Lys Asp Ser Glu Asp 
865                 870                 875                 880 


Met Gly Val Val Val Ser Leu Gly Xaa Gly Asn Arg Cys Val Lys Gly 
                885                 890                 895     


Asp Ser Leu Ser Leu Lys Gly Glu Xaa Val Asn Asp Cys His Ala Glu 
            900                 905                 910         


Ile Ile Ser Arg Arg Gly Phe Ile Arg Phe Leu Tyr Ser Glu Leu Met 
        915                 920                 925             


Lys Tyr Asn Ser Gln Xaa Ala Lys Asp Ser Ile Phe Glu Pro Ala Lys 
    930                 935                 940                 


Gly Gly Glu Lys Leu Gln Ile Lys Lys Xaa Val Ser Phe His Leu Tyr 
945                 950                 955                 960 


Ile Ser Xaa Ala Pro Cys Gly Asp Gly Ala Leu Phe Asp Lys Ser Cys 
                965                 970                 975     


Ser Asp Arg Ala Met Glu Ser Xaa Glu Ser Arg His Tyr Pro Val Phe 
            980                 985                 990         


Glu Asn Pro Lys Gln Gly Lys Leu  Arg Xaa Lys Val Glu  Asn Gly Glu 
        995                 1000                 1005             


Gly Xaa  Ile Pro Val Glu Ser  Ser Asp Ile Val Pro  Xaa Trp Asp 
    1010                 1015                 1020             


Gly Ile  Arg Leu Gly Glu Arg  Leu Arg Xaa Met Ser  Cys Ser Asp 
    1025                 1030                 1035             


Lys Ile  Leu Arg Trp Asn Val  Leu Gly Leu Gln Gly  Ala Leu Leu 
    1040                 1045                 1050             


Xaa His  Phe Leu Gln Pro Ile  Tyr Leu Lys Ser Val  Xaa Leu Gly 
    1055                 1060                 1065             


Tyr Leu  Phe Ser Gln Gly His  Leu Xaa Arg Ala Ile  Cys Cys Arg 
    1070                 1075                 1080             


Val Xaa  Arg Asp Gly Ser Ala  Phe Glu Asp Gly Leu  Arg His Pro 
    1085                 1090                 1095             


Phe Ile  Val Asn His Pro Lys  Val Gly Arg Val Ser  Ile Tyr Asp 
    1100                 1105                 1110             


Ser Lys  Arg Gln Ser Gly Lys  Xaa Lys Glu Xaa Ser  Val Asn Trp 
    1115                 1120                 1125             


Cys Leu  Ala Asp Gly Tyr Asp  Leu Glu Ile Leu Asp  Gly Xaa Arg 
    1130                 1135                 1140             


Gly Xaa  Val Asp Gly Pro Arg  Asn Glu Leu Ser Arg  Val Ser Lys 
    1145                 1150                 1155             


Lys Asn  Ile Phe Leu Leu Phe  Lys Lys Leu Cys Ser  Phe Arg Tyr 
    1160                 1165                 1170             


Arg Arg  Asp Leu Leu Arg Leu  Ser Tyr Gly Glu Ala  Lys Lys Ala 
    1175                 1180                 1185             


Ala Arg  Asp Tyr Glu Xaa Ala  Lys Asn Tyr Phe Lys  Lys Gly Leu 
    1190                 1195                 1200             


Lys Asp  Met Gly Tyr Gly Asn  Trp Ile Ser Lys Pro  Gln Glu Glu 
    1205                 1210                 1215             


Lys Asn  Phe Tyr Leu Cys Pro  Val 
    1220                 1225     


<210> 1548
<211> 1119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1058)..(1058)
<223> Selenocysteine

<400> 1548
Met Ala Gly Ala Pro Arg Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly 
1               5                   10                  15      


Glu Pro Gly Gly Ala Glu Arg Ala Ala Gly Xaa Ser Arg Arg Arg Gly 
            20                  25                  30          


Leu Arg Ala Cys Asp Glu Glu Phe Ala Cys Pro Glu Leu Glu Ala Leu 
        35                  40                  45              


Phe Arg Gly Tyr Xaa Leu Arg Leu Glu Gln Ala Ala Xaa Leu Lys Ala 
    50                  55                  60                  


Leu Ala Val Leu Ser Leu Leu Ala Gly Ala Leu Ala Leu Ala Glu Leu 
65                  70                  75                  80  


Leu Gly Ala Pro Gly Pro Ala Pro Gly Leu Ala Lys Gly Ser His Pro 
                85                  90                  95      


Val His Cys Val Leu Phe Leu Ala Leu Leu Val Val Xaa Asn Val Arg 
            100                 105                 110         


Ser Leu Gln Val Pro Gln Leu Gln Gln Val Gly Gln Leu Ala Leu Leu 
        115                 120                 125             


Phe Ser Leu Xaa Phe Ala Leu Leu Cys Cys Pro Phe Ala Leu Gly Gly 
    130                 135                 140                 


Pro Ala Arg Gly Ser Ala Gly Ala Ala Gly Gly Pro Ala Xaa Ala Glu 
145                 150                 155                 160 


Gln Gly Val Trp Gln Leu Leu Leu Val Xaa Phe Val Ser Tyr Ala Leu 
                165                 170                 175     


Leu Pro Val Arg Ser Leu Leu Ala Ile Gly Phe Gly Leu Val Val Ala 
            180                 185                 190         


Ala Ser His Leu Leu Val Xaa Ala Xaa Leu Val Pro Ala Lys Arg Pro 
        195                 200                 205             


Arg Leu Trp Arg Xaa Leu Gly Ala Asn Ala Leu Leu Phe Val Gly Val 
    210                 215                 220                 


Asn Met Tyr Gly Val Phe Val Arg Ile Leu Xaa Glu Arg Ser Gln Arg 
225                 230                 235                 240 


Lys Ala Phe Leu Gln Ala Arg Ser Cys Ile Glu Asp Arg Leu Arg Leu 
                245                 250                 255     


Glu Asp Glu Asn Glu Lys Gln Glu Arg Leu Leu Met Ser Leu Leu Pro 
            260                 265                 270         


Arg Asn Val Ala Met Glu Met Lys Glu Asp Phe Leu Lys Pro Pro Glu 
        275                 280                 285             


Arg Ile Phe His Lys Ile Tyr Ile Gln Arg His Asp Asn Val Ser Ile 
    290                 295                 300                 


Leu Phe Ala Asp Ile Val Gly Phe Xaa Gly Leu Ala Ser Gln Cys Xaa 
305                 310                 315                 320 


Ala Gln Glu Leu Val Lys Leu Leu Asn Glu Leu Phe Gly Lys Phe Asp 
                325                 330                 335     


Glu Leu Ala Xaa Glu Asn His Cys Arg Arg Ile Lys Ile Leu Gly Asp 
            340                 345                 350         


Cys Tyr Tyr Cys Val Ser Gly Leu Xaa Gln Pro Lys Xaa Asp His Ala 
        355                 360                 365             


His Cys Cys Val Glu Met Gly Leu Asp Met Ile Asp Xaa Ile Xaa Ser 
    370                 375                 380                 


Val Ala Glu Ala Xaa Glu Val Asp Leu Asn Met Arg Val Gly Leu His 
385                 390                 395                 400 


Xaa Gly Arg Val Leu Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Tyr 
                405                 410                 415     


Asp Val Trp Ser Asn Asp Val Xaa Leu Ala Asn Val Met Glu Ala Ala 
            420                 425                 430         


Gly Leu Pro Gly Lys Val His Ile Xaa Lys Xaa Xaa Leu Ala Cys Leu 
        435                 440                 445             


Asn Gly Asp Tyr Glu Val Glu Pro Gly Tyr Gly His Glu Arg Asn Ser 
    450                 455                 460                 


Phe Leu Lys Xaa His Asn Ile Glu Xaa Phe Phe Ile Val Pro Ser His 
465                 470                 475                 480 


Arg Arg Lys Ile Phe Pro Gly Leu Ile Leu Ser Asp Ile Lys Pro Ala 
                485                 490                 495     


Lys Arg Met Lys Phe Lys Xaa Val Cys Tyr Leu Leu Val Gln Leu Met 
            500                 505                 510         


His Cys Arg Lys Met Phe Lys Ala Glu Ile Pro Phe Ser Asn Val Met 
        515                 520                 525             


Xaa Cys Glu Asp Asp Asp Lys Arg Arg Ala Leu Arg Xaa Ala Ser Glu 
    530                 535                 540                 


Lys Leu Arg Asn Arg Ser Ser Phe Ser Xaa Asn Val Val Tyr Xaa Xaa 
545                 550                 555                 560 


Pro Gly Xaa Arg Val Asn Arg Tyr Ile Ser Arg Leu Leu Glu Ala Arg 
                565                 570                 575     


Gln Xaa Glu Leu Glu Met Ala Asp Leu Asn Phe Phe Xaa Leu Lys Tyr 
            580                 585                 590         


Lys His Val Glu Arg Glu Gln Lys Tyr His Gln Leu Gln Asp Glu Tyr 
        595                 600                 605             


Phe Xaa Ser Ala Val Val Leu Xaa Leu Ile Leu Ala Ala Leu Phe Gly 
    610                 615                 620                 


Leu Val Tyr Leu Leu Ile Phe Pro Gln Ser Val Val Val Leu Leu Leu 
625                 630                 635                 640 


Leu Val Phe Cys Ile Cys Phe Leu Val Ala Cys Val Leu Tyr Leu His 
                645                 650                 655     


Ile Xaa Arg Val Gln Cys Phe Pro Gly Cys Leu Xaa Ile Gln Ile Arg 
            660                 665                 670         


Xaa Val Leu Cys Ile Phe Ile Val Val Leu Ile Tyr Ser Val Ala Gln 
        675                 680                 685             


Gly Cys Val Val Gly Cys Leu Pro Trp Ala Trp Ser Ser Lys Pro Asn 
    690                 695                 700                 


Ser Ser Leu Val Val Leu Ser Ser Gly Gly Gln Arg Xaa Ala Leu Pro 
705                 710                 715                 720 


Xaa Leu Pro Cys Glu Ser Xaa His His Ala Leu Leu Cys Cys Leu Val 
                725                 730                 735     


Gly Xaa Leu Pro Leu Ala Ile Phe Phe Arg Val Ser Ser Leu Pro Lys 
            740                 745                 750         


Met Ile Leu Leu Ser Gly Leu Xaa Xaa Ser Tyr Ile Leu Val Leu Glu 
        755                 760                 765             


Leu Ser Gly Tyr Xaa Arg Xaa Gly Gly Gly Ala Val Ser Gly Arg Ser 
    770                 775                 780                 


Tyr Glu Pro Ile Val Ala Ile Leu Leu Phe Ser Cys Ala Leu Ala Leu 
785                 790                 795                 800 


His Ala Arg Gln Val Asp Ile Arg Leu Arg Leu Asp Tyr Leu Trp Ala 
                805                 810                 815     


Ala Gln Ala Glu Glu Glu Arg Glu Asp Met Glu Lys Val Lys Leu Asp 
            820                 825                 830         


Asn Arg Arg Ile Leu Phe Asn Leu Leu Pro Ala His Val Ala Gln His 
        835                 840                 845             


Phe Leu Met Ser Asn Pro Arg Asn Met Asp Leu Tyr Tyr Gln Ser Tyr 
    850                 855                 860                 


Ser Gln Val Gly Val Met Phe Ala Ser Ile Pro Asn Phe Asn Asp Phe 
865                 870                 875                 880 


Tyr Ile Glu Leu Asp Gly Asn Asn Met Gly Val Glu Cys Leu Arg Leu 
                885                 890                 895     


Leu Asn Glu Ile Ile Ala Asp Phe Asp Glu Leu Met Glu Lys Asp Phe 
            900                 905                 910         


Tyr Lys Asp Ile Glu Lys Ile Lys Xaa Ile Gly Ser Xaa Tyr Met Ala 
        915                 920                 925             


Ala Val Gly Leu Ala Pro Xaa Ser Gly Xaa Lys Ala Lys Lys Ser Ile 
    930                 935                 940                 


Ser Ser His Leu Ser Xaa Leu Ala Asp Phe Ala Ile Glu Met Phe Asp 
945                 950                 955                 960 


Val Leu Asp Glu Ile Asn Tyr Gln Ser Tyr Asn Asp Phe Val Leu Arg 
                965                 970                 975     


Val Gly Ile Asn Val Gly Pro Val Val Ala Gly Val Ile Gly Ala Arg 
            980                 985                 990         


Arg Pro Gln Tyr Asp Ile Trp Gly  Asn Xaa Val Asn Val  Ala Ser Arg 
        995                 1000                 1005             


Met Asp  Ser Xaa Gly Val Gln  Gly Arg Ile Gln Val  Xaa Glu Glu 
    1010                 1015                 1020             


Val His  Arg Leu Leu Arg Arg  Cys Pro Tyr His Phe  Val Cys Arg 
    1025                 1030                 1035             


Gly Lys  Val Ser Val Lys Gly  Lys Gly Glu Met Leu  Xaa Tyr Phe 
    1040                 1045                 1050             


Leu Glu  Gly Arg Xaa Asp Gly  Asn Gly Ser Gln Ile  Arg Ser Leu 
    1055                 1060                 1065             


Gly Leu  Asp Arg Lys Met Cys  Pro Phe Gly Arg Ala  Gly Leu Gln 
    1070                 1075                 1080             


Gly Arg  Arg Pro Pro Val Cys  Pro Met Pro Gly Val  Ser Val Arg 
    1085                 1090                 1095             


Ala Gly  Leu Pro Pro His Ser  Pro Gly Gln Tyr Leu  Pro Ser Ala 
    1100                 1105                 1110             


Ala Ala  Gly Lys Glu Ala 
    1115                 


<210> 1549
<211> 338
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<400> 1549
Met Tyr Gly Val Phe Val Arg Ile Leu Xaa Glu Arg Ser Gln Arg Lys 
1               5                   10                  15      


Ala Phe Leu Gln Ala Arg Ser Cys Ile Glu Asp Arg Leu Arg Leu Glu 
            20                  25                  30          


Asp Glu Asn Glu Lys Gln Glu Arg Leu Leu Met Ser Leu Leu Pro Arg 
        35                  40                  45              


Asn Val Ala Met Glu Met Lys Glu Asp Phe Leu Lys Pro Pro Glu Arg 
    50                  55                  60                  


Ile Phe His Lys Ile Tyr Ile Gln Arg His Asp Asn Val Ser Ile Leu 
65                  70                  75                  80  


Phe Ala Asp Ile Val Gly Phe Xaa Gly Leu Ala Ser Gln Cys Xaa Ala 
                85                  90                  95      


Gln Glu Leu Val Lys Leu Leu Asn Glu Leu Phe Gly Lys Phe Asp Glu 
            100                 105                 110         


Leu Ala Xaa Glu Asn His Cys Arg Arg Ile Lys Ile Leu Gly Asp Cys 
        115                 120                 125             


Tyr Tyr Cys Val Ser Gly Leu Xaa Gln Pro Lys Xaa Asp His Ala His 
    130                 135                 140                 


Cys Cys Val Glu Met Gly Leu Asp Met Ile Asp Xaa Ile Xaa Ser Val 
145                 150                 155                 160 


Ala Glu Ala Xaa Glu Val Asp Leu Asn Met Arg Val Gly Leu His Xaa 
                165                 170                 175     


Gly Arg Val Leu Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Tyr Asp 
            180                 185                 190         


Val Trp Ser Asn Asp Val Xaa Leu Ala Asn Val Met Glu Ala Ala Gly 
        195                 200                 205             


Leu Pro Gly Lys Val His Ile Xaa Lys Xaa Xaa Leu Ala Cys Leu Asn 
    210                 215                 220                 


Gly Asp Tyr Glu Val Glu Pro Gly Tyr Gly His Glu Arg Asn Ser Phe 
225                 230                 235                 240 


Leu Lys Xaa His Asn Ile Glu Xaa Phe Phe Ile Val Pro Ser His Arg 
                245                 250                 255     


Arg Lys Ile Phe Pro Gly Leu Ile Leu Ser Asp Ile Lys Pro Ala Lys 
            260                 265                 270         


Arg Met Lys Phe Lys Xaa Val Cys Tyr Leu Leu Val Gln Leu Met His 
        275                 280                 285             


Cys Arg Lys Met Phe Lys Ala Glu Ile Pro Phe Ser Asn Val Met Xaa 
    290                 295                 300                 


Cys Glu Asp Asp Asp Lys Val Gln Ile His Pro Ser Leu Ser Gly Leu 
305                 310                 315                 320 


Asp Val Leu Leu Gly Phe Trp Ser Pro Xaa Leu Gln Arg Gly Arg Leu 
                325                 330                 335     


Cys Xaa 
        


<210> 1550
<211> 1457
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1383)..(1383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1410)..(1410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1421)..(1421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1452)..(1452)
<223> Selenocysteine

<400> 1550
Met Leu Val Phe Gly Asp Glu Xaa His Ser His Phe Leu Val Ile Gly 
1               5                   10                  15      


Gln Ala Val Asp Asp Val Arg Leu Ala Gln Asn Met Ala Gln Met Asn 
            20                  25                  30          


Asp Val Ile Leu Ser Pro Asn Cys Trp Gln Leu Cys Asp Arg Ser Met 
        35                  40                  45              


Ile Glu Ile Glu Ser Val Pro Asp Gln Arg Ala Val Lys Val Asn Phe 
    50                  55                  60                  


Leu Lys Pro Pro Pro Asn Phe Asn Phe Asp Glu Phe Phe Xaa Lys Cys 
65                  70                  75                  80  


Xaa Xaa Phe Met His Tyr Tyr Pro Ser Gly Glu His Lys Asn Leu Leu 
                85                  90                  95      


Arg Leu Ala Cys Xaa Leu Lys Pro Asp Pro Glu Leu Glu Met Ser Leu 
            100                 105                 110         


Gln Lys Tyr Val Met Glu Ser Ile Leu Lys Gln Ile Asp Asn Lys Gln 
        115                 120                 125             


Leu Gln Gly Tyr Leu Ser Glu Leu Arg Pro Val Xaa Ile Val Phe Val 
    130                 135                 140                 


Asn Leu Met Phe Glu Asp Gln Asp Lys Ala Glu Glu Ile Gly Pro Ala 
145                 150                 155                 160 


Ile Gln Asp Ala Tyr Met His Ile Xaa Ser Val Leu Lys Ile Phe Gln 
                165                 170                 175     


Gly Gln Ile Asn Lys Val Phe Met Phe Asp Lys Gly Cys Ser Phe Leu 
            180                 185                 190         


Cys Val Phe Gly Phe Pro Gly Glu Lys Val Pro Asp Glu Leu Xaa His 
        195                 200                 205             


Ala Leu Glu Cys Ala Met Asp Ile Phe Asp Phe Cys Ser Gln Val His 
    210                 215                 220                 


Lys Ile Gln Xaa Val Ser Ile Gly Val Ala Ser Gly Ile Val Phe Cys 
225                 230                 235                 240 


Gly Ile Val Gly His Xaa Val Arg His Glu Tyr Xaa Val Ile Gly Gln 
                245                 250                 255     


Lys Val Asn Leu Ala Ala Arg Met Met Met Tyr Tyr Pro Gly Ile Val 
            260                 265                 270         


Xaa Cys Asp Ser Val Xaa Tyr Asn Gly Ser Asn Leu Pro Ala Tyr Phe 
        275                 280                 285             


Phe Lys Glu Leu Pro Lys Lys Val Met Lys Gly Val Ala Asp Ser Gly 
    290                 295                 300                 


Pro Leu Tyr Gln Tyr Trp Gly Arg Xaa Glu Lys Val Met Phe Gly Met 
305                 310                 315                 320 


Ala Cys Leu Ile Cys Asn Arg Lys Glu Asp Tyr Pro Leu Leu Gly Arg 
                325                 330                 335     


Asn Lys Glu Ile Asn Tyr Phe Met Tyr Xaa Met Lys Lys Phe Leu Ile 
            340                 345                 350         


Ser Asn Ser Ser Gln Val Leu Met Tyr Glu Gly Leu Pro Gly Tyr Gly 
        355                 360                 365             


Lys Ser Gln Ile Leu Met Lys Ile Glu Tyr Leu Ala Gln Gly Lys Asn 
    370                 375                 380                 


His Arg Ile Ile Ala Ile Ser Leu Asn Lys Ile Ser Phe His Gln Xaa 
385                 390                 395                 400 


Phe Tyr Xaa Ile Gln Met Phe Met Ala Asn Val Leu Gly Leu Asp Xaa 
                405                 410                 415     


Cys Lys His Tyr Lys Glu Arg Gln Xaa Asn Leu Arg Asn Lys Val Met 
            420                 425                 430         


Xaa Leu Leu Asp Glu Lys Phe Tyr Cys Leu Leu Asn Asp Ile Phe His 
        435                 440                 445             


Val Gln Phe Pro Ile Ser Arg Glu Ile Ser Arg Met Ser Xaa Leu Lys 
    450                 455                 460                 


Lys Gln Lys Gln Leu Glu Ile Leu Phe Met Lys Ile Leu Lys Leu Ile 
465                 470                 475                 480 


Val Lys Glu Glu Arg Ile Ile Phe Ile Ile Asp Glu Ala Gln Phe Val 
                485                 490                 495     


Asp Ser Xaa Ser Trp Arg Phe Met Glu Lys Leu Ile Arg Xaa Leu Pro 
            500                 505                 510         


Ile Phe Ile Ile Met Ser Leu Cys Pro Phe Val Asn Ile Pro Cys Ala 
        515                 520                 525             


Ala Ala Arg Ala Val Ile Lys Asn Arg Asn Xaa Xaa Tyr Ile Val Ile 
    530                 535                 540                 


Gly Ala Val Gln Pro Asn Asp Ile Ser Asn Lys Ile Cys Leu Asp Leu 
545                 550                 555                 560 


Asn Val Ser Cys Ile Ser Lys Glu Leu Asp Ser Tyr Leu Gly Glu Gly 
                565                 570                 575     


Ser Cys Gly Ile Pro Phe Tyr Cys Glu Glu Leu Leu Lys Asn Leu Glu 
            580                 585                 590         


His His Glu Val Leu Val Phe Gln Gln Xaa Glu Ser Glu Glu Lys Xaa 
        595                 600                 605             


Asn Arg Xaa Trp Asn Asn Leu Phe Lys Tyr Ser Ile Lys Leu Xaa Glu 
    610                 615                 620                 


Lys Leu Asn Met Val Xaa Leu His Ser Asp Lys Glu Ser Glu Glu Val 
625                 630                 635                 640 


Cys His Leu Xaa Ser Gly Val Arg Leu Lys Asn Leu Ser Pro Pro Xaa 
                645                 650                 655     


Ser Leu Lys Glu Ile Ser Leu Ile Gln Leu Asp Ser Met Arg Leu Ser 
            660                 665                 670         


His Gln Met Leu Val Arg Cys Ala Ala Ile Ile Gly Leu Xaa Phe Xaa 
        675                 680                 685             


Xaa Glu Leu Leu Phe Glu Ile Leu Pro Cys Trp Asn Met Lys Met Met 
    690                 695                 700                 


Ile Lys Xaa Leu Ala Xaa Leu Val Glu Ser Asn Ile Phe Tyr Cys Phe 
705                 710                 715                 720 


Arg Asn Gly Lys Glu Leu Gln Lys Ala Leu Lys Gln Asn Asp Pro Ser 
                725                 730                 735     


Phe Glu Val His Tyr Arg Ser Leu Ser Leu Lys Pro Ser Glu Gly Met 
            740                 745                 750         


Asp His Gly Glu Glu Glu Gln Leu Arg Glu Leu Glu Asn Glu Val Ile 
        755                 760                 765             


Glu Cys His Arg Ile Arg Phe Cys Asn Pro Met Met Gln Lys Xaa Ala 
    770                 775                 780                 


Tyr Glu Leu Trp Leu Lys Asp Gln Arg Lys Ala Met His Leu Lys Cys 
785                 790                 795                 800 


Ala Arg Phe Leu Glu Glu Asp Ala His Arg Cys Asp His Cys Arg Gly 
                805                 810                 815     


Arg Asp Phe Ile Pro Tyr His His Phe Xaa Val Asn Ile Arg Leu Asn 
            820                 825                 830         


Ala Leu Asp Met Asp Ala Ile Lys Lys Met Ala Met Ser His Gly Phe 
        835                 840                 845             


Lys Xaa Glu Glu Lys Leu Ile Leu Ser Asn Ser Glu Ile Pro Glu Xaa 
    850                 855                 860                 


Ser Ala Phe Phe Pro Glu Asn Arg Ser Pro Glu Glu Ile Arg Glu Lys 
865                 870                 875                 880 


Ile Leu Asn Phe Phe Asp His Val Leu Xaa Lys Met Lys Xaa Ser Asp 
                885                 890                 895     


Glu Asp Ile Ile Pro Leu Glu Ser Cys Gln Cys Glu Glu Ile Leu Glu 
            900                 905                 910         


Ile Val Ile Leu Pro Leu Ala His His Phe Leu Ala Leu Gly Glu Asn 
        915                 920                 925             


Asp Lys Ala Leu Tyr Tyr Phe Leu Glu Ile Ala Ser Ala Tyr Leu Ile 
    930                 935                 940                 


Phe Cys Asp Asn Tyr Met Ala Tyr Met Tyr Leu Asn Glu Gly Gln Lys 
945                 950                 955                 960 


Leu Leu Lys Xaa Leu Lys Lys Asp Lys Ser Trp Ser Gln Xaa Phe Glu 
                965                 970                 975     


Ser Ala Xaa Phe Tyr Ser Leu Lys Gly Glu Val Cys Phe Asn Met Gly 
            980                 985                 990         


Gln Ile Val Leu Ala Lys Lys Met  Leu Arg Lys Ala Leu  Lys Leu Leu 
        995                 1000                 1005             


Asn Arg  Ile Phe Pro Tyr Asn  Leu Ile Ser Leu Phe  Leu His Ile 
    1010                 1015                 1020             


His Val  Glu Lys Asn Arg His  Phe His Tyr Val Asn  Arg Gln Ala 
    1025                 1030                 1035             


Gln Glu  Ser Pro Pro Pro Gly  Lys Lys Arg Leu Ala  Gln Leu Tyr 
    1040                 1045                 1050             


Arg Gln  Xaa Val Cys Leu Ser  Leu Leu Trp Arg Ile  Tyr Ser Tyr 
    1055                 1060                 1065             


Ser Tyr  Leu Phe His Cys Lys  Tyr Tyr Ala His Leu  Ala Val Met 
    1070                 1075                 1080             


Met Gln  Met Asn Xaa Ala Leu  Glu Xaa Gln Asn Cys  Phe Gln Ile 
    1085                 1090                 1095             


Ile Lys  Ala Tyr Leu Asp Tyr  Ser Leu Tyr His His  Leu Ala Gly 
    1100                 1105                 1110             


Tyr Lys  Gly Val Trp Phe Lys  Tyr Glu Val Met Ala  Met Glu His 
    1115                 1120                 1125             


Ile Phe  Asn Leu Pro Leu Lys  Gly Glu Gly Ile Glu  Ile Val Ala 
    1130                 1135                 1140             


Tyr Val  Ala Glu Xaa Leu Val  Phe Asn Lys Leu Ile  Met Gly His 
    1145                 1150                 1155             


Leu Asp  Leu Ala Ile Glu Leu  Gly Ser Arg Ala Leu  Gln Met Trp 
    1160                 1165                 1170             


Ala Leu  Leu Gln Asn Pro Asn  Arg His Tyr Gln Ser  Leu Cys Arg 
    1175                 1180                 1185             


Leu Ser  Arg Cys Leu Leu Leu  Asn Ser Arg Tyr Pro  Gln Leu Ile 
    1190                 1195                 1200             


Gln Val  Leu Gly Arg Leu Trp  Glu Leu Ser Val Xaa  Gln Glu His 
    1205                 1210                 1215             


Ile Phe  Ser Lys Ala Phe Phe  Tyr Phe Val Cys Leu  Asp Ile Leu 
    1220                 1225                 1230             


Leu Tyr  Ser Gly Phe Val Tyr  Arg Xaa Phe Glu Glu  Cys Leu Glu 
    1235                 1240                 1245             


Phe Ile  His Gln Tyr Glu Asn  Asn Arg Ile Leu Lys  Phe His Ser 
    1250                 1255                 1260             


Gly Leu  Leu Leu Gly Leu Tyr  Ser Ser Val Ala Ile  Trp Tyr Ala 
    1265                 1270                 1275             


Arg Leu  Gln Glu Trp Asp Asn  Phe Tyr Lys Phe Ser  Asn Arg Ala 
    1280                 1285                 1290             


Lys Asn  Leu Leu Pro Arg Arg  Xaa Met Xaa Leu Xaa  Tyr Tyr Asp 
    1295                 1300                 1305             


Gly Ile  Ser Arg Tyr Met Glu  Gly Gln Val Leu His  Leu Gln Lys 
    1310                 1315                 1320             


Gln Ile  Lys Glu Gln Ser Glu  Asn Ala Gln Ala Ser  Gly Glu Glu 
    1325                 1330                 1335             


Leu Leu  Lys Asn Leu Glu Asn  Leu Val Ala Gln Asn  Xaa Xaa Gly 
    1340                 1345                 1350             


Pro Val  Phe Cys Pro Arg Leu  Tyr His Leu Met Ala  Tyr Val Cys 
    1355                 1360                 1365             


Ile Leu  Met Gly Asp Gly Gln  Lys Cys Gly Leu Phe  Leu Asn Xaa 
    1370                 1375                 1380             


Ala Leu  Arg Leu Ser Glu Xaa  Gln Gly Asn Ile Leu  Glu Lys Cys 
    1385                 1390                 1395             


Trp Leu  Asn Met Asn Lys Glu  Ser Trp Tyr Ser Xaa  Ser Glu Leu 
    1400                 1405                 1410             


Lys Glu  Asp Gln Trp Leu Gln  Xaa Ile Leu Ser Leu  Pro Ser Trp 
    1415                 1420                 1425             


Glu Lys  Ile Val Ala Gly Arg  Val Asn Ile Gln Asp  Leu Gln Lys 
    1430                 1435                 1440             


Asn Lys  Phe Leu Met Arg Ala  Asn Xaa Val Asp Asn  His Phe 
    1445                 1450                 1455         


<210> 1551
<211> 1610
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1017)..(1017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1117)..(1117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1245)..(1245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1368)..(1368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1395)..(1395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1454)..(1454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1456)..(1456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1504)..(1505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1536)..(1536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1543)..(1543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1563)..(1563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1605)..(1605)
<223> Selenocysteine

<400> 1551
Met Asn Xaa Pro Lys Glu Glu Phe Gln Asp Trp Pro Ile Val Arg Ile 
1               5                   10                  15      


Ala Ala His Leu Pro Asp Leu Ile Val Tyr Gly His Phe Ser Pro Glu 
            20                  25                  30          


Arg Pro Phe Met Asp Tyr Phe Asp Gly Val Leu Met Phe Val Asp Ile 
        35                  40                  45              


Ser Gly Phe Xaa Ala Met Xaa Glu Lys Phe Ser Ser Ala Met Tyr Met 
    50                  55                  60                  


Asp Arg Gly Ala Glu Gln Leu Val Glu Ile Leu Asn Tyr His Ile Ser 
65                  70                  75                  80  


Ala Ile Val Glu Lys Val Leu Ile Phe Gly Gly Asp Ile Leu Lys Phe 
                85                  90                  95      


Ala Gly Asp Ala Leu Leu Ala Leu Trp Arg Val Glu Arg Lys Gln Leu 
            100                 105                 110         


Lys Asn Ile Ile Xaa Val Val Ile Lys Cys Ser Leu Glu Ile His Gly 
        115                 120                 125             


Leu Phe Glu Xaa Gln Glu Trp Glu Glu Gly Leu Asp Ile Arg Val Lys 
    130                 135                 140                 


Ile Gly Leu Ala Ala Gly His Ile Ser Met Leu Val Phe Gly Asp Glu 
145                 150                 155                 160 


Xaa His Ser His Phe Leu Val Ile Gly Gln Ala Val Asp Asp Val Arg 
                165                 170                 175     


Leu Ala Gln Asn Met Ala Gln Met Asn Asp Val Ile Leu Ser Pro Asn 
            180                 185                 190         


Cys Trp Gln Leu Cys Asp Arg Ser Met Ile Glu Ile Glu Ser Val Pro 
        195                 200                 205             


Asp Gln Arg Ala Val Lys Val Asn Phe Leu Lys Pro Pro Pro Asn Phe 
    210                 215                 220                 


Asn Phe Asp Glu Phe Phe Xaa Lys Cys Xaa Xaa Phe Met His Tyr Tyr 
225                 230                 235                 240 


Pro Ser Gly Glu His Lys Asn Leu Leu Arg Leu Ala Cys Xaa Leu Lys 
                245                 250                 255     


Pro Asp Pro Glu Leu Glu Met Ser Leu Gln Lys Tyr Val Met Glu Ser 
            260                 265                 270         


Ile Leu Lys Gln Ile Asp Asn Lys Gln Leu Gln Gly Tyr Leu Ser Glu 
        275                 280                 285             


Leu Arg Pro Val Xaa Ile Val Phe Val Asn Leu Met Phe Glu Asp Gln 
    290                 295                 300                 


Asp Lys Ala Glu Glu Ile Gly Pro Ala Ile Gln Asp Ala Tyr Met His 
305                 310                 315                 320 


Ile Xaa Ser Val Leu Lys Ile Phe Gln Gly Gln Ile Asn Lys Val Phe 
                325                 330                 335     


Met Phe Asp Lys Gly Cys Ser Phe Leu Cys Val Phe Gly Phe Pro Gly 
            340                 345                 350         


Glu Lys Val Pro Asp Glu Leu Xaa His Ala Leu Glu Cys Ala Met Asp 
        355                 360                 365             


Ile Phe Asp Phe Cys Ser Gln Val His Lys Ile Gln Xaa Val Ser Ile 
    370                 375                 380                 


Gly Val Ala Ser Gly Ile Val Phe Cys Gly Ile Val Gly His Xaa Val 
385                 390                 395                 400 


Arg His Glu Tyr Xaa Val Ile Gly Gln Lys Val Asn Leu Ala Ala Arg 
                405                 410                 415     


Met Met Met Tyr Tyr Pro Gly Ile Val Xaa Cys Asp Ser Val Xaa Tyr 
            420                 425                 430         


Asn Gly Ser Asn Leu Pro Ala Tyr Phe Phe Lys Glu Leu Pro Lys Lys 
        435                 440                 445             


Val Met Lys Gly Val Ala Asp Ser Gly Pro Leu Tyr Gln Tyr Trp Gly 
    450                 455                 460                 


Arg Xaa Glu Lys Val Met Phe Gly Met Ala Cys Leu Ile Cys Asn Arg 
465                 470                 475                 480 


Lys Glu Asp Tyr Pro Leu Leu Gly Arg Asn Lys Glu Ile Asn Tyr Phe 
                485                 490                 495     


Met Tyr Xaa Met Lys Lys Phe Leu Ile Ser Asn Ser Ser Gln Val Leu 
            500                 505                 510         


Met Tyr Glu Gly Leu Pro Gly Tyr Gly Lys Ser Gln Ile Leu Met Lys 
        515                 520                 525             


Ile Glu Tyr Leu Ala Gln Gly Lys Asn His Arg Ile Ile Ala Ile Ser 
    530                 535                 540                 


Leu Asn Lys Ile Ser Phe His Gln Xaa Phe Tyr Xaa Ile Gln Met Phe 
545                 550                 555                 560 


Met Ala Asn Val Leu Gly Leu Asp Xaa Cys Lys His Tyr Lys Glu Arg 
                565                 570                 575     


Gln Xaa Asn Leu Arg Asn Lys Val Met Xaa Leu Leu Asp Glu Lys Phe 
            580                 585                 590         


Tyr Cys Leu Leu Asn Asp Ile Phe His Val Gln Phe Pro Ile Ser Arg 
        595                 600                 605             


Glu Ile Ser Arg Met Ser Xaa Leu Lys Lys Gln Lys Gln Leu Glu Ile 
    610                 615                 620                 


Leu Phe Met Lys Ile Leu Lys Leu Ile Val Lys Glu Glu Arg Ile Ile 
625                 630                 635                 640 


Phe Ile Ile Asp Glu Ala Gln Phe Val Asp Ser Xaa Ser Trp Arg Phe 
                645                 650                 655     


Met Glu Lys Leu Ile Arg Xaa Leu Pro Ile Phe Ile Ile Met Ser Leu 
            660                 665                 670         


Cys Pro Phe Val Asn Ile Pro Cys Ala Ala Ala Arg Ala Val Ile Lys 
        675                 680                 685             


Asn Arg Asn Xaa Xaa Tyr Ile Val Ile Gly Ala Val Gln Pro Asn Asp 
    690                 695                 700                 


Ile Ser Asn Lys Ile Cys Leu Asp Leu Asn Val Ser Cys Ile Ser Lys 
705                 710                 715                 720 


Glu Leu Asp Ser Tyr Leu Gly Glu Gly Ser Cys Gly Ile Pro Phe Tyr 
                725                 730                 735     


Cys Glu Glu Leu Leu Lys Asn Leu Glu His His Glu Val Leu Val Phe 
            740                 745                 750         


Gln Gln Xaa Glu Ser Glu Glu Lys Xaa Asn Arg Xaa Trp Asn Asn Leu 
        755                 760                 765             


Phe Lys Tyr Ser Ile Lys Leu Xaa Glu Lys Leu Asn Met Val Xaa Leu 
    770                 775                 780                 


His Ser Asp Lys Glu Ser Glu Glu Val Cys His Leu Xaa Ser Gly Val 
785                 790                 795                 800 


Arg Leu Lys Asn Leu Ser Pro Pro Xaa Ser Leu Lys Glu Ile Ser Leu 
                805                 810                 815     


Ile Gln Leu Asp Ser Met Arg Leu Ser His Gln Met Leu Val Arg Cys 
            820                 825                 830         


Ala Ala Ile Ile Gly Leu Xaa Phe Xaa Xaa Glu Leu Leu Phe Glu Ile 
        835                 840                 845             


Leu Pro Cys Trp Asn Met Lys Met Met Ile Lys Xaa Leu Ala Xaa Leu 
    850                 855                 860                 


Val Glu Ser Asn Ile Phe Tyr Cys Phe Arg Asn Gly Lys Glu Leu Gln 
865                 870                 875                 880 


Lys Ala Leu Lys Gln Asn Asp Pro Ser Phe Glu Val His Tyr Arg Ser 
                885                 890                 895     


Leu Ser Leu Lys Pro Ser Glu Gly Met Asp His Gly Glu Glu Glu Gln 
            900                 905                 910         


Leu Arg Glu Leu Glu Asn Glu Val Ile Glu Cys His Arg Ile Arg Phe 
        915                 920                 925             


Cys Asn Pro Met Met Gln Lys Xaa Ala Tyr Glu Leu Trp Leu Lys Asp 
    930                 935                 940                 


Gln Arg Lys Ala Met His Leu Lys Cys Ala Arg Phe Leu Glu Glu Asp 
945                 950                 955                 960 


Ala His Arg Cys Asp His Cys Arg Gly Arg Asp Phe Ile Pro Tyr His 
                965                 970                 975     


His Phe Xaa Val Asn Ile Arg Leu Asn Ala Leu Asp Met Asp Ala Ile 
            980                 985                 990         


Lys Lys Met Ala Met Ser His Gly  Phe Lys Xaa Glu Glu  Lys Leu Ile 
        995                 1000                 1005             


Leu Ser  Asn Ser Glu Ile Pro  Glu Xaa Ser Ala Phe  Phe Pro Glu 
    1010                 1015                 1020             


Asn Arg  Ser Pro Glu Glu Ile  Arg Glu Lys Ile Leu  Asn Phe Phe 
    1025                 1030                 1035             


Asp His  Val Leu Xaa Lys Met  Lys Xaa Ser Asp Glu  Asp Ile Ile 
    1040                 1045                 1050             


Pro Leu  Glu Ser Cys Gln Cys  Glu Glu Ile Leu Glu  Ile Val Ile 
    1055                 1060                 1065             


Leu Pro  Leu Ala His His Phe  Leu Ala Leu Gly Glu  Asn Asp Lys 
    1070                 1075                 1080             


Ala Leu  Tyr Tyr Phe Leu Glu  Ile Ala Ser Ala Tyr  Leu Ile Phe 
    1085                 1090                 1095             


Cys Asp  Asn Tyr Met Ala Tyr  Met Tyr Leu Asn Glu  Gly Gln Lys 
    1100                 1105                 1110             


Leu Leu  Lys Xaa Leu Lys Lys  Asp Lys Ser Trp Ser  Gln Xaa Phe 
    1115                 1120                 1125             


Glu Ser  Ala Xaa Phe Tyr Ser  Leu Lys Gly Glu Val  Cys Phe Asn 
    1130                 1135                 1140             


Met Gly  Gln Ile Val Leu Ala  Lys Lys Met Leu Arg  Lys Ala Leu 
    1145                 1150                 1155             


Lys Leu  Leu Asn Arg Ile Phe  Pro Tyr Asn Leu Ile  Ser Leu Phe 
    1160                 1165                 1170             


Leu His  Ile His Val Glu Lys  Asn Arg His Phe His  Tyr Val Asn 
    1175                 1180                 1185             


Arg Gln  Ala Gln Glu Ser Pro  Pro Pro Gly Lys Lys  Arg Leu Ala 
    1190                 1195                 1200             


Gln Leu  Tyr Arg Gln Xaa Val  Cys Leu Ser Leu Leu  Trp Arg Ile 
    1205                 1210                 1215             


Tyr Ser  Tyr Ser Tyr Leu Phe  His Cys Lys Tyr Tyr  Ala His Leu 
    1220                 1225                 1230             


Ala Val  Met Met Gln Met Asn  Xaa Ala Leu Glu Xaa  Gln Asn Cys 
    1235                 1240                 1245             


Phe Gln  Ile Ile Lys Ala Tyr  Leu Asp Tyr Ser Leu  Tyr His His 
    1250                 1255                 1260             


Leu Ala  Gly Tyr Lys Gly Val  Trp Phe Lys Tyr Glu  Val Met Ala 
    1265                 1270                 1275             


Met Glu  His Ile Phe Asn Leu  Pro Leu Lys Gly Glu  Gly Ile Glu 
    1280                 1285                 1290             


Ile Val  Ala Tyr Val Ala Glu  Xaa Leu Val Phe Asn  Lys Leu Ile 
    1295                 1300                 1305             


Met Gly  His Leu Asp Leu Ala  Ile Glu Leu Gly Ser  Arg Ala Leu 
    1310                 1315                 1320             


Gln Met  Trp Ala Leu Leu Gln  Asn Pro Asn Arg His  Tyr Gln Ser 
    1325                 1330                 1335             


Leu Cys  Arg Leu Ser Arg Cys  Leu Leu Leu Asn Ser  Arg Tyr Pro 
    1340                 1345                 1350             


Gln Leu  Ile Gln Val Leu Gly  Arg Leu Trp Glu Leu  Ser Val Xaa 
    1355                 1360                 1365             


Gln Glu  His Ile Phe Ser Lys  Ala Phe Phe Tyr Phe  Val Cys Leu 
    1370                 1375                 1380             


Asp Ile  Leu Leu Tyr Ser Gly  Phe Val Tyr Arg Xaa  Phe Glu Glu 
    1385                 1390                 1395             


Cys Leu  Glu Phe Ile His Gln  Tyr Glu Asn Asn Arg  Ile Leu Lys 
    1400                 1405                 1410             


Phe His  Ser Gly Leu Leu Leu  Gly Leu Tyr Ser Ser  Val Ala Ile 
    1415                 1420                 1425             


Trp Tyr  Ala Arg Leu Gln Glu  Trp Asp Asn Phe Tyr  Lys Phe Ser 
    1430                 1435                 1440             


Asn Arg  Ala Lys Asn Leu Leu  Pro Arg Arg Xaa Met  Xaa Leu Xaa 
    1445                 1450                 1455             


Tyr Tyr  Asp Gly Ile Ser Arg  Tyr Met Glu Gly Gln  Val Leu His 
    1460                 1465                 1470             


Leu Gln  Lys Gln Ile Lys Glu  Gln Ser Glu Asn Ala  Gln Ala Ser 
    1475                 1480                 1485             


Gly Glu  Glu Leu Leu Lys Asn  Leu Glu Asn Leu Val  Ala Gln Asn 
    1490                 1495                 1500             


Xaa Xaa  Gly Pro Val Phe Cys  Pro Arg Leu Tyr His  Leu Met Ala 
    1505                 1510                 1515             


Tyr Val  Cys Ile Leu Met Gly  Asp Gly Gln Lys Cys  Gly Leu Phe 
    1520                 1525                 1530             


Leu Asn  Xaa Ala Leu Arg Leu  Ser Glu Xaa Gln Gly  Asn Ile Leu 
    1535                 1540                 1545             


Glu Lys  Cys Trp Leu Asn Met  Asn Lys Glu Ser Trp  Tyr Ser Xaa 
    1550                 1555                 1560             


Ser Glu  Leu Lys Glu Asp Gln  Trp Leu Gln Xaa Ile  Leu Ser Leu 
    1565                 1570                 1575             


Pro Ser  Trp Glu Lys Ile Val  Ala Gly Arg Val Asn  Ile Gln Asp 
    1580                 1585                 1590             


Leu Gln  Lys Asn Lys Phe Leu  Met Arg Ala Asn Xaa  Val Asp Asn 
    1595                 1600                 1605             


His Phe  
    1610 


<210> 1552
<211> 73
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<400> 1552
Met Asn Xaa Pro Lys Glu Glu Phe Gln Asp Trp Pro Ile Val Arg Ile 
1               5                   10                  15      


Ala Ala His Leu Pro Asp Leu Ile Val Tyr Gly His Phe Ser Pro Glu 
            20                  25                  30          


Arg Pro Phe Met Asp Tyr Phe Asp Gly Val Leu Met Phe Val Asp Ile 
        35                  40                  45              


Ser Gly Lys Cys Lys Arg Asp Val Cys Leu Met Trp Met Ser Asn Arg 
    50                  55                  60                  


Leu Ala Trp Glu Phe Xaa Cys Arg Ala 
65                  70              


<210> 1553
<211> 1518
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1117)..(1117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1276)..(1276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1364)..(1364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1366)..(1366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1412)..(1413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1444)..(1444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1451)..(1451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1471)..(1471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1482)..(1482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<400> 1553
Met Ser Leu Ser Glu Gly Asp Ala Leu Leu Ala Leu Trp Arg Val Glu 
1               5                   10                  15      


Arg Lys Gln Leu Lys Asn Ile Ile Xaa Val Val Ile Lys Cys Ser Leu 
            20                  25                  30          


Glu Ile His Gly Leu Phe Glu Xaa Gln Glu Trp Glu Glu Gly Leu Asp 
        35                  40                  45              


Ile Arg Val Lys Ile Gly Leu Ala Ala Gly His Ile Ser Met Leu Val 
    50                  55                  60                  


Phe Gly Asp Glu Xaa His Ser His Phe Leu Val Ile Gly Gln Ala Val 
65                  70                  75                  80  


Asp Asp Val Arg Leu Ala Gln Asn Met Ala Gln Met Asn Asp Val Ile 
                85                  90                  95      


Leu Ser Pro Asn Cys Trp Gln Leu Cys Asp Arg Ser Met Ile Glu Ile 
            100                 105                 110         


Glu Ser Val Pro Asp Gln Arg Ala Val Lys Val Asn Phe Leu Lys Pro 
        115                 120                 125             


Pro Pro Asn Phe Asn Phe Asp Glu Phe Phe Xaa Lys Cys Xaa Xaa Phe 
    130                 135                 140                 


Met His Tyr Tyr Pro Ser Gly Glu His Lys Asn Leu Leu Arg Leu Ala 
145                 150                 155                 160 


Cys Xaa Leu Lys Pro Asp Pro Glu Leu Glu Met Ser Leu Gln Lys Tyr 
                165                 170                 175     


Val Met Glu Ser Ile Leu Lys Gln Ile Asp Asn Lys Gln Leu Gln Gly 
            180                 185                 190         


Tyr Leu Ser Glu Leu Arg Pro Val Xaa Ile Val Phe Val Asn Leu Met 
        195                 200                 205             


Phe Glu Asp Gln Asp Lys Ala Glu Glu Ile Gly Pro Ala Ile Gln Asp 
    210                 215                 220                 


Ala Tyr Met His Ile Xaa Ser Val Leu Lys Ile Phe Gln Gly Gln Ile 
225                 230                 235                 240 


Asn Lys Val Phe Met Phe Asp Lys Gly Cys Ser Phe Leu Cys Val Phe 
                245                 250                 255     


Gly Phe Pro Gly Glu Lys Val Pro Asp Glu Leu Xaa His Ala Leu Glu 
            260                 265                 270         


Cys Ala Met Asp Ile Phe Asp Phe Cys Ser Gln Val His Lys Ile Gln 
        275                 280                 285             


Xaa Val Ser Ile Gly Val Ala Ser Gly Ile Val Phe Cys Gly Ile Val 
    290                 295                 300                 


Gly His Xaa Val Arg His Glu Tyr Xaa Val Ile Gly Gln Lys Val Asn 
305                 310                 315                 320 


Leu Ala Ala Arg Met Met Met Tyr Tyr Pro Gly Ile Val Xaa Cys Asp 
                325                 330                 335     


Ser Val Xaa Tyr Asn Gly Ser Asn Leu Pro Ala Tyr Phe Phe Lys Glu 
            340                 345                 350         


Leu Pro Lys Lys Val Met Lys Gly Val Ala Asp Ser Gly Pro Leu Tyr 
        355                 360                 365             


Gln Tyr Trp Gly Arg Xaa Glu Lys Val Met Phe Gly Met Ala Cys Leu 
    370                 375                 380                 


Ile Cys Asn Arg Lys Glu Asp Tyr Pro Leu Leu Gly Arg Asn Lys Glu 
385                 390                 395                 400 


Ile Asn Tyr Phe Met Tyr Xaa Met Lys Lys Phe Leu Ile Ser Asn Ser 
                405                 410                 415     


Ser Gln Val Leu Met Tyr Glu Gly Leu Pro Gly Tyr Gly Lys Ser Gln 
            420                 425                 430         


Ile Leu Met Lys Ile Glu Tyr Leu Ala Gln Gly Lys Asn His Arg Ile 
        435                 440                 445             


Ile Ala Ile Ser Leu Asn Lys Ile Ser Phe His Gln Xaa Phe Tyr Xaa 
    450                 455                 460                 


Ile Gln Met Phe Met Ala Asn Val Leu Gly Leu Asp Xaa Cys Lys His 
465                 470                 475                 480 


Tyr Lys Glu Arg Gln Xaa Asn Leu Arg Asn Lys Val Met Xaa Leu Leu 
                485                 490                 495     


Asp Glu Lys Phe Tyr Cys Leu Leu Asn Asp Ile Phe His Val Gln Phe 
            500                 505                 510         


Pro Ile Ser Arg Glu Ile Ser Arg Met Ser Xaa Leu Lys Lys Gln Lys 
        515                 520                 525             


Gln Leu Glu Ile Leu Phe Met Lys Ile Leu Lys Leu Ile Val Lys Glu 
    530                 535                 540                 


Glu Arg Ile Ile Phe Ile Ile Asp Glu Ala Gln Phe Val Asp Ser Xaa 
545                 550                 555                 560 


Ser Trp Arg Phe Met Glu Lys Leu Ile Arg Xaa Leu Pro Ile Phe Ile 
                565                 570                 575     


Ile Met Ser Leu Cys Pro Phe Val Asn Ile Pro Cys Ala Ala Ala Arg 
            580                 585                 590         


Ala Val Ile Lys Asn Arg Asn Xaa Xaa Tyr Ile Val Ile Gly Ala Val 
        595                 600                 605             


Gln Pro Asn Asp Ile Ser Asn Lys Ile Cys Leu Asp Leu Asn Val Ser 
    610                 615                 620                 


Cys Ile Ser Lys Glu Leu Asp Ser Tyr Leu Gly Glu Gly Ser Cys Gly 
625                 630                 635                 640 


Ile Pro Phe Tyr Cys Glu Glu Leu Leu Lys Asn Leu Glu His His Glu 
                645                 650                 655     


Val Leu Val Phe Gln Gln Xaa Glu Ser Glu Glu Lys Xaa Asn Arg Xaa 
            660                 665                 670         


Trp Asn Asn Leu Phe Lys Tyr Ser Ile Lys Leu Xaa Glu Lys Leu Asn 
        675                 680                 685             


Met Val Xaa Leu His Ser Asp Lys Glu Ser Glu Glu Val Cys His Leu 
    690                 695                 700                 


Xaa Ser Gly Val Arg Leu Lys Asn Leu Ser Pro Pro Xaa Ser Leu Lys 
705                 710                 715                 720 


Glu Ile Ser Leu Ile Gln Leu Asp Ser Met Arg Leu Ser His Gln Met 
                725                 730                 735     


Leu Val Arg Cys Ala Ala Ile Ile Gly Leu Xaa Phe Xaa Xaa Glu Leu 
            740                 745                 750         


Leu Phe Glu Ile Leu Pro Cys Trp Asn Met Lys Met Met Ile Lys Xaa 
        755                 760                 765             


Leu Ala Xaa Leu Val Glu Ser Asn Ile Phe Tyr Cys Phe Arg Asn Gly 
    770                 775                 780                 


Lys Glu Leu Gln Lys Ala Leu Lys Gln Asn Asp Pro Ser Phe Glu Val 
785                 790                 795                 800 


His Tyr Arg Ser Leu Ser Leu Lys Pro Ser Glu Gly Met Asp His Gly 
                805                 810                 815     


Glu Glu Glu Gln Leu Arg Glu Leu Glu Asn Glu Val Ile Glu Cys His 
            820                 825                 830         


Arg Ile Arg Phe Cys Asn Pro Met Met Gln Lys Xaa Ala Tyr Glu Leu 
        835                 840                 845             


Trp Leu Lys Asp Gln Arg Lys Ala Met His Leu Lys Cys Ala Arg Phe 
    850                 855                 860                 


Leu Glu Glu Asp Ala His Arg Cys Asp His Cys Arg Gly Arg Asp Phe 
865                 870                 875                 880 


Ile Pro Tyr His His Phe Xaa Val Asn Ile Arg Leu Asn Ala Leu Asp 
                885                 890                 895     


Met Asp Ala Ile Lys Lys Met Ala Met Ser His Gly Phe Lys Xaa Glu 
            900                 905                 910         


Glu Lys Leu Ile Leu Ser Asn Ser Glu Ile Pro Glu Xaa Ser Ala Phe 
        915                 920                 925             


Phe Pro Glu Asn Arg Ser Pro Glu Glu Ile Arg Glu Lys Ile Leu Asn 
    930                 935                 940                 


Phe Phe Asp His Val Leu Xaa Lys Met Lys Xaa Ser Asp Glu Asp Ile 
945                 950                 955                 960 


Ile Pro Leu Glu Ser Cys Gln Cys Glu Glu Ile Leu Glu Ile Val Ile 
                965                 970                 975     


Leu Pro Leu Ala His His Phe Leu Ala Leu Gly Glu Asn Asp Lys Ala 
            980                 985                 990         


Leu Tyr Tyr Phe Leu Glu Ile Ala  Ser Ala Tyr Leu Ile  Phe Cys Asp 
        995                 1000                 1005             


Asn Tyr  Met Ala Tyr Met Tyr  Leu Asn Glu Gly Gln  Lys Leu Leu 
    1010                 1015                 1020             


Lys Xaa  Leu Lys Lys Asp Lys  Ser Trp Ser Gln Xaa  Phe Glu Ser 
    1025                 1030                 1035             


Ala Xaa  Phe Tyr Ser Leu Lys  Gly Glu Val Cys Phe  Asn Met Gly 
    1040                 1045                 1050             


Gln Ile  Val Leu Ala Lys Lys  Met Leu Arg Lys Ala  Leu Lys Leu 
    1055                 1060                 1065             


Leu Asn  Arg Ile Phe Pro Tyr  Asn Leu Ile Ser Leu  Phe Leu His 
    1070                 1075                 1080             


Ile His  Val Glu Lys Asn Arg  His Phe His Tyr Val  Asn Arg Gln 
    1085                 1090                 1095             


Ala Gln  Glu Ser Pro Pro Pro  Gly Lys Lys Arg Leu  Ala Gln Leu 
    1100                 1105                 1110             


Tyr Arg  Gln Xaa Val Cys Leu  Ser Leu Leu Trp Arg  Ile Tyr Ser 
    1115                 1120                 1125             


Tyr Ser  Tyr Leu Phe His Cys  Lys Tyr Tyr Ala His  Leu Ala Val 
    1130                 1135                 1140             


Met Met  Gln Met Asn Xaa Ala  Leu Glu Xaa Gln Asn  Cys Phe Gln 
    1145                 1150                 1155             


Ile Ile  Lys Ala Tyr Leu Asp  Tyr Ser Leu Tyr His  His Leu Ala 
    1160                 1165                 1170             


Gly Tyr  Lys Gly Val Trp Phe  Lys Tyr Glu Val Met  Ala Met Glu 
    1175                 1180                 1185             


His Ile  Phe Asn Leu Pro Leu  Lys Gly Glu Gly Ile  Glu Ile Val 
    1190                 1195                 1200             


Ala Tyr  Val Ala Glu Xaa Leu  Val Phe Asn Lys Leu  Ile Met Gly 
    1205                 1210                 1215             


His Leu  Asp Leu Ala Ile Glu  Leu Gly Ser Arg Ala  Leu Gln Met 
    1220                 1225                 1230             


Trp Ala  Leu Leu Gln Asn Pro  Asn Arg His Tyr Gln  Ser Leu Cys 
    1235                 1240                 1245             


Arg Leu  Ser Arg Cys Leu Leu  Leu Asn Ser Arg Tyr  Pro Gln Leu 
    1250                 1255                 1260             


Ile Gln  Val Leu Gly Arg Leu  Trp Glu Leu Ser Val  Xaa Gln Glu 
    1265                 1270                 1275             


His Ile  Phe Ser Lys Ala Phe  Phe Tyr Phe Val Cys  Leu Asp Ile 
    1280                 1285                 1290             


Leu Leu  Tyr Ser Gly Phe Val  Tyr Arg Xaa Phe Glu  Glu Cys Leu 
    1295                 1300                 1305             


Glu Phe  Ile His Gln Tyr Glu  Asn Asn Arg Ile Leu  Lys Phe His 
    1310                 1315                 1320             


Ser Gly  Leu Leu Leu Gly Leu  Tyr Ser Ser Val Ala  Ile Trp Tyr 
    1325                 1330                 1335             


Ala Arg  Leu Gln Glu Trp Asp  Asn Phe Tyr Lys Phe  Ser Asn Arg 
    1340                 1345                 1350             


Ala Lys  Asn Leu Leu Pro Arg  Arg Xaa Met Xaa Leu  Xaa Tyr Tyr 
    1355                 1360                 1365             


Asp Gly  Ile Ser Arg Tyr Met  Glu Gly Gln Val Leu  His Leu Gln 
    1370                 1375                 1380             


Lys Gln  Ile Lys Glu Gln Ser  Glu Asn Ala Gln Ala  Ser Gly Glu 
    1385                 1390                 1395             


Glu Leu  Leu Lys Asn Leu Glu  Asn Leu Val Ala Gln  Asn Xaa Xaa 
    1400                 1405                 1410             


Gly Pro  Val Phe Cys Pro Arg  Leu Tyr His Leu Met  Ala Tyr Val 
    1415                 1420                 1425             


Cys Ile  Leu Met Gly Asp Gly  Gln Lys Cys Gly Leu  Phe Leu Asn 
    1430                 1435                 1440             


Xaa Ala  Leu Arg Leu Ser Glu  Xaa Gln Gly Asn Ile  Leu Glu Lys 
    1445                 1450                 1455             


Cys Trp  Leu Asn Met Asn Lys  Glu Ser Trp Tyr Ser  Xaa Ser Glu 
    1460                 1465                 1470             


Leu Lys  Glu Asp Gln Trp Leu  Gln Xaa Ile Leu Ser  Leu Pro Ser 
    1475                 1480                 1485             


Trp Glu  Lys Ile Val Ala Gly  Arg Val Asn Ile Gln  Asp Leu Gln 
    1490                 1495                 1500             


Lys Asn  Lys Phe Leu Met Arg  Ala Asn Xaa Val Asp  Asn His Phe 
    1505                 1510                 1515             


<210> 1554
<211> 250
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<400> 1554
Xaa Tyr Ser Ile Lys Leu Xaa Glu Lys Leu Asn Met Val Xaa Leu His 
1               5                   10                  15      


Ser Asp Lys Glu Ser Glu Glu Val Cys His Leu Xaa Ser Gly Val Arg 
            20                  25                  30          


Leu Lys Asn Leu Ser Pro Pro Xaa Ser Leu Lys Glu Ile Ser Leu Ile 
        35                  40                  45              


Gln Leu Asp Ser Met Arg Leu Ser His Gln Met Leu Val Arg Cys Ala 
    50                  55                  60                  


Ala Ile Ile Gly Leu Xaa Phe Xaa Xaa Glu Leu Leu Phe Glu Ile Leu 
65                  70                  75                  80  


Pro Cys Trp Asn Met Lys Met Met Ile Lys Xaa Leu Ala Xaa Leu Val 
                85                  90                  95      


Glu Ser Asn Ile Phe Tyr Cys Phe Arg Asn Gly Lys Glu Leu Gln Lys 
            100                 105                 110         


Ala Leu Lys Gln Asn Asp Pro Ser Phe Glu Val His Tyr Arg Ser Leu 
        115                 120                 125             


Ser Leu Lys Pro Ser Glu Gly Met Asp His Gly Glu Glu Glu Gln Leu 
    130                 135                 140                 


Arg Glu Leu Glu Asn Glu Val Ile Glu Cys His Arg Ile Arg Phe Cys 
145                 150                 155                 160 


Asn Pro Met Met Gln Lys Xaa Ala Tyr Glu Leu Trp Leu Lys Asp Gln 
                165                 170                 175     


Arg Lys Ala Met His Leu Lys Cys Ala Arg Phe Leu Glu Glu Asp Ala 
            180                 185                 190         


His Arg Cys Asp His Cys Arg Gly Arg Asp Phe Ile Pro Tyr His His 
        195                 200                 205             


Phe Xaa Val Asn Ile Arg Leu Asn Ala Leu Asp Met Asp Ala Ile Lys 
    210                 215                 220                 


Lys Met Ala Met Ser His Gly Phe Lys Arg Cys Met Arg Leu Gly Asp 
225                 230                 235                 240 


Xaa Ala Ser Pro Tyr Tyr Ile Leu Gln Val 
                245                 250 


<210> 1555
<211> 100
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 1555
Met Glu Leu Ala Leu Gln Gln Xaa Tyr Gln Asp Xaa Cys Asn Cys Ile 
1               5                   10                  15      


Lys Ser Arg Ile Lys Leu Glu Phe Glu Lys Arg Gln Gln Glu Arg Leu 
            20                  25                  30          


Leu Leu Ser Leu Leu Pro Ala His Ile Ala Met Glu Met Lys Ala Glu 
        35                  40                  45              


Ile Ile Gln Arg Leu Gln Gly Pro Lys Ala Gly Gln Met Glu Asn Xaa 
    50                  55                  60                  


Asn Asn Phe His Asn Leu Tyr Val Lys Arg His Xaa Asn Val Ser Ile 
65                  70                  75                  80  


Leu Tyr Ala Asp Ile Val Gly Phe Xaa Arg Leu Ala Ser Asp Cys Ser 
                85                  90                  95      


Pro Gly Glu Leu 
            100 


<210> 1556
<211> 1091
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1058)..(1058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<400> 1556
Met Trp Gln Glu Ala Met Arg Arg Arg Arg Tyr Leu Arg Asp Arg Ser 
1               5                   10                  15      


Glu Glu Ala Ala Gly Gly Gly Asp Gly Leu Pro Arg Ser Arg Asp Trp 
            20                  25                  30          


Leu Tyr Glu Ser Tyr Tyr Cys Met Ser Gln Gln His Pro Leu Ile Val 
        35                  40                  45              


Phe Leu Leu Leu Ile Val Met Gly Ser Cys Leu Ala Leu Leu Ala Val 
    50                  55                  60                  


Phe Phe Ala Leu Gly Leu Glu Val Glu Asp His Val Ala Phe Leu Ile 
65                  70                  75                  80  


Xaa Val Pro Xaa Ala Leu Ala Ile Phe Phe Ala Ile Phe Ile Leu Val 
                85                  90                  95      


Cys Ile Glu Ser Val Phe Lys Lys Leu Leu Arg Leu Phe Ser Leu Val 
            100                 105                 110         


Ile Trp Ile Cys Leu Val Ala Met Gly Tyr Leu Phe Met Cys Phe Gly 
        115                 120                 125             


Gly Xaa Val Ser Pro Trp Asp Gln Val Ser Phe Phe Leu Phe Ile Ile 
    130                 135                 140                 


Phe Val Val Tyr Xaa Met Leu Pro Phe Asn Met Arg Asp Ala Ile Ile 
145                 150                 155                 160 


Ala Ser Val Leu Xaa Ser Ser Ser His Xaa Ile Val Leu Ser Val Cys 
                165                 170                 175     


Leu Ser Ala Xaa Pro Gly Gly Lys Glu His Leu Val Trp Gln Ile Leu 
            180                 185                 190         


Ala Asn Val Ile Ile Phe Ile Cys Gly Asn Leu Ala Gly Ala Tyr His 
        195                 200                 205             


Lys His Leu Met Glu Leu Ala Leu Gln Gln Xaa Tyr Gln Asp Xaa Cys 
    210                 215                 220                 


Asn Cys Ile Lys Ser Arg Ile Lys Leu Glu Phe Glu Lys Arg Gln Gln 
225                 230                 235                 240 


Glu Arg Leu Leu Leu Ser Leu Leu Pro Ala His Ile Ala Met Glu Met 
                245                 250                 255     


Lys Ala Glu Ile Ile Gln Arg Leu Gln Gly Pro Lys Ala Gly Gln Met 
            260                 265                 270         


Glu Asn Xaa Asn Asn Phe His Asn Leu Tyr Val Lys Arg His Xaa Asn 
        275                 280                 285             


Val Ser Ile Leu Tyr Ala Asp Ile Val Gly Phe Xaa Arg Leu Ala Ser 
    290                 295                 300                 


Asp Cys Ser Pro Gly Glu Leu Val His Met Leu Asn Glu Leu Phe Gly 
305                 310                 315                 320 


Lys Phe Asp Gln Ile Ala Lys Glu Asn Glu Cys Met Arg Ile Lys Ile 
                325                 330                 335     


Leu Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu Pro Ile Ser Leu Pro 
            340                 345                 350         


Asn His Ala Lys Asn Cys Val Lys Met Gly Leu Asp Met Cys Glu Ala 
        355                 360                 365             


Ile Lys Lys Val Arg Asp Ala Xaa Gly Val Asp Ile Asn Met Arg Val 
    370                 375                 380                 


Gly Val His Ser Gly Asn Val Leu Cys Gly Val Ile Gly Leu Gln Lys 
385                 390                 395                 400 


Trp Gln Tyr Asp Val Trp Ser His Asp Val Xaa Leu Ala Asn His Met 
                405                 410                 415     


Glu Ala Gly Gly Val Pro Gly Arg Val His Ile Ser Ser Val Xaa Leu 
            420                 425                 430         


Glu His Leu Asn Gly Ala Tyr Lys Val Glu Glu Gly Asp Gly Asp Ile 
        435                 440                 445             


Arg Asp Pro Tyr Leu Lys Gln His Leu Val Lys Xaa Tyr Phe Val Ile 
    450                 455                 460                 


Asn Pro Lys Gly Glu Arg Arg Ser Pro Gln His Leu Phe Arg Pro Arg 
465                 470                 475                 480 


His Xaa Leu Asp Gly Ala Lys Met Arg Ala Ser Val Arg Met Xaa Arg 
                485                 490                 495     


Tyr Leu Glu Ser Trp Gly Ala Ala Lys Pro Phe Ala His Leu His His 
            500                 505                 510         


Arg Asp Ser Met Xaa Xaa Glu Asn Gly Lys Ile Ser Xaa Xaa Asp Val 
        515                 520                 525             


Pro Met Gly Gln His Asn Phe Gln Asn Arg Xaa Leu Arg Xaa Lys Ser 
    530                 535                 540                 


Gln Lys Lys Arg Phe Glu Glu Glu Leu Asn Glu Arg Met Ile Gln Ala 
545                 550                 555                 560 


Ile Asp Gly Ile Asn Ala Gln Lys Gln Trp Leu Lys Ser Glu Asp Ile 
                565                 570                 575     


Gln Arg Ile Ser Leu Leu Phe Tyr Asn Lys Val Leu Glu Lys Glu Tyr 
            580                 585                 590         


Arg Ala Xaa Ala Leu Pro Ala Phe Lys Tyr Tyr Val Xaa Cys Ala Cys 
        595                 600                 605             


Leu Ile Phe Phe Cys Ile Phe Ile Val Gln Ile Leu Val Leu Pro Lys 
    610                 615                 620                 


Xaa Ser Val Leu Gly Ile Ser Phe Gly Ala Ala Phe Leu Leu Leu Ala 
625                 630                 635                 640 


Phe Ile Leu Phe Val Cys Phe Ala Gly Gln Leu Leu Gln Cys Ser Lys 
                645                 650                 655     


Lys Ala Ser Pro Leu Leu Met Trp Leu Leu Lys Ser Ser Gly Ile Ile 
            660                 665                 670         


Ala Asn Arg Pro Trp Pro Arg Ile Ser Leu Xaa Ile Ile Xaa Xaa Ala 
        675                 680                 685             


Ile Ile Leu Met Met Ala Val Phe Asn Met Phe Phe Leu Ser Asp Ser 
    690                 695                 700                 


Glu Glu Xaa Ile Pro Pro Xaa Ala Asn Xaa Xaa Asn Xaa Ser Phe Ser 
705                 710                 715                 720 


Ala Ser Asn Asn Gln Val Ala Ile Leu Arg Ala Gln Asn Leu Phe Phe 
                725                 730                 735     


Leu Pro Tyr Phe Ile Tyr Ser Cys Ile Leu Gly Leu Ile Ser Cys Ser 
            740                 745                 750         


Val Phe Leu Arg Val Asn Tyr Glu Leu Lys Met Leu Ile Met Met Val 
        755                 760                 765             


Ala Leu Val Gly Tyr Asn Xaa Ile Leu Leu His Xaa His Ala His Val 
    770                 775                 780                 


Leu Gly Asp Tyr Ser Gln Val Leu Phe Glu Arg Pro Gly Ile Trp Lys 
785                 790                 795                 800 


Asp Leu Lys Xaa Met Gly Ser Val Ser Leu Ser Ile Phe Phe Ile Xaa 
                805                 810                 815     


Leu Leu Val Leu Gly Arg Gln Asn Glu Tyr Tyr Cys Arg Leu Asp Phe 
            820                 825                 830         


Leu Trp Lys Asn Lys Phe Lys Lys Glu Arg Glu Glu Ile Glu Xaa Met 
        835                 840                 845             


Glu Asn Leu Asn Arg Val Leu Leu Glu Asn Val Leu Pro Ala His Val 
    850                 855                 860                 


Ala Glu His Phe Leu Ala Arg Ser Leu Lys Asn Glu Glu Leu Tyr His 
865                 870                 875                 880 


Gln Ser Tyr Asp Cys Val Cys Val Met Phe Ala Ser Ile Pro Asp Phe 
                885                 890                 895     


Lys Glu Phe Tyr Xaa Glu Ser Asp Val Asn Lys Glu Gly Leu Glu Cys 
            900                 905                 910         


Leu Arg Leu Leu Asn Glu Ile Ile Ala Asp Phe Asp Asp Leu Leu Ser 
        915                 920                 925             


Lys Pro Lys Phe Ser Gly Val Glu Lys Ile Lys Xaa Ile Gly Ser Xaa 
    930                 935                 940                 


Tyr Met Ala Ala Xaa Gly Leu Ser Ala Val Pro Ser Gln Glu His Ser 
945                 950                 955                 960 


Gln Glu Pro Glu Arg Gln Tyr Met His Ile Gly Xaa Met Val Glu Phe 
                965                 970                 975     


Ala Phe Ala Leu Val Gly Lys Leu Asp Ala Ile Asn Lys His Ser Phe 
            980                 985                 990         


Asn Asp Phe Lys Leu Arg Val Gly  Ile Asn His Gly Pro  Val Ile Ala 
        995                 1000                 1005             


Gly Val  Ile Gly Ala Gln Lys  Pro Gln Tyr Asp Ile  Trp Gly Asn 
    1010                 1015                 1020             


Xaa Val  Asn Val Ala Ser Arg  Met Asp Ser Xaa Gly  Val Leu Asp 
    1025                 1030                 1035             


Lys Ile  Gln Val Xaa Glu Glu  Xaa Ser Leu Val Leu  Gln Xaa Leu 
    1040                 1045                 1050             


Gly Tyr  Xaa Cys Xaa Cys Arg  Gly Ile Ile Asn Val  Lys Gly Lys 
    1055                 1060                 1065             


Gly Asp  Leu Lys Xaa Tyr Phe  Val Asn Xaa Glu Met  Ser Arg Ser 
    1070                 1075                 1080             


Leu Ser  Gln Ser Asn Val Ala  Ser 
    1085                 1090     


<210> 1557
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<400> 1557
Xaa Leu Gly Asp Tyr Ser Gln Val Leu Phe Glu Arg Pro Gly Ile Trp 
1               5                   10                  15      


Lys Asp Leu Lys Xaa Met Gly Ser Val Ser Leu Ser Ile Phe Phe Ile 
            20                  25                  30          


Xaa Leu Leu Val Leu Gly Arg Gln Val Arg Leu Leu Met Glu Glu Gln 
        35                  40                  45              


Ile Gln Lys Arg Ala Gly Gly Asp Arg Asp His Gly Glu Pro Glu Pro 
    50                  55                  60                  


Arg Ala Ala Gly Glu Arg Ala Ser Arg Ala Arg Gly 
65                  70                  75      


<210> 1558
<211> 298
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<400> 1558
Cys Ala Ile Ala Val Gly Ile Met Ser Tyr Tyr Met Ala Asp Arg Lys 
1               5                   10                  15      


His Arg Lys Ala Phe Leu Glu Ala Arg Gln Ser Leu Glu Val Lys Met 
            20                  25                  30          


Asn Leu Glu Glu Gln Ser Gln Gln Gln His Val Ala Asp Glu Met Leu 
        35                  40                  45              


Lys Asp Met Lys Lys Asp Glu Ser Gln Lys Asp Gln Gln Gln Phe Asn 
    50                  55                  60                  


Xaa Met Tyr Met Tyr Arg His Glu Asn Val Ser Ile Leu Phe Ala Asp 
65                  70                  75                  80  


Ile Val Gly Phe Xaa Gln Leu Ser Ser Ala Cys Ser Ala Gln Glu Leu 
                85                  90                  95      


Val Lys Leu Leu Asn Glu Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala 
            100                 105                 110         


Lys Tyr His Gln Leu Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys 
        115                 120                 125             


Ile Cys Gly Leu Pro Asp Tyr Arg Glu Asp His Ala Val Cys Ser Ile 
    130                 135                 140                 


Leu Met Gly Leu Ala Met Val Glu Ala Ile Ser Tyr Val Arg Glu Lys 
145                 150                 155                 160 


Xaa Lys Xaa Gly Val Asp Met Arg Val Gly Val His Xaa Gly Xaa Val 
                165                 170                 175     


Leu Gly Gly Val Leu Gly Gln Lys Arg Trp Gln Tyr Asp Val Trp Ser 
            180                 185                 190         


Xaa Asp Val Xaa Val Ala Asn Lys Met Glu Ala Gly Gly Ile Pro Gly 
        195                 200                 205             


Arg Val His Ile Ser Gln Ser Xaa Met Asp Cys Leu Lys Gly Glu Phe 
    210                 215                 220                 


Asp Val Glu Pro Gly Asp Gly Gly Ser Arg Cys Asp Tyr Leu Glu Glu 
225                 230                 235                 240 


Lys Gly Ile Glu Xaa Tyr Leu Ile Ile Ala Ser Lys Pro Glu Val Lys 
                245                 250                 255     


Lys Xaa Ala Xaa Gln Asn Gly Leu Asn Gly Ser Ala Leu Pro Asn Gly 
            260                 265                 270         


Ala Pro Ala Ser Ser Lys Ser Ser Ser Pro Ala Leu Ile Glu Xaa Lys 
        275                 280                 285             


Glu Pro Asn Gly Ser Ala His Ser Ser Gly 
    290                 295             


<210> 1559
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<400> 1559
Met Gly Leu Ile Leu Ala Asn Val Phe Leu Tyr Leu Cys Ala Ile Ala 
1               5                   10                  15      


Val Gly Ile Met Ser Tyr Tyr Met Ala Asp Arg Lys His Arg Lys Ala 
            20                  25                  30          


Phe Leu Glu Ala Arg Gln Ser Leu Glu Val Lys Met Asn Leu Glu Glu 
        35                  40                  45              


Gln Ser Gln Gln Gln Glu Asn Leu Met Leu Ser Ile Leu Pro Lys His 
    50                  55                  60                  


Val Ala Asp Glu Met Leu Lys Asp Met Lys Lys Asp Glu Ser Gln Lys 
65                  70                  75                  80  


Asp Gln Gln Gln Phe Asn Xaa Met Tyr Met Tyr Arg His Glu Asn Val 
                85                  90                  95      


Ser Ile Leu Phe Ala Asp Ile Val Gly Phe Xaa Gln Leu Ser Ser Ala 
            100                 105                 110         


Cys Ser Ala Gln Glu Leu Val Lys Leu Leu Asn Glu Leu Phe Ala Arg 
        115                 120                 125             


Phe Asp Lys Leu Ala Ala Lys Tyr His Gln Leu Arg Ile Lys Ile Leu 
    130                 135                 140                 


Gly Asp Cys Tyr Tyr Cys Ile Cys Gly Leu Pro 
145                 150                 155 


<210> 1560
<211> 112
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<400> 1560
Met Pro Arg Asn Gln Gly Phe Ser Glu Pro Glu Tyr Ser Ala Glu Tyr 
1               5                   10                  15      


Ser Ala Glu Tyr Ser Val Ser Leu Pro Ser Asp Pro Asp Arg Gly Val 
            20                  25                  30          


Gly Arg Xaa His Glu Ile Ser Val Arg Asn Ser Gly Ser Cys Leu Cys 
        35                  40                  45              


Leu Pro Arg Phe Met Arg Leu Xaa Phe Val Pro Glu Ser Leu Glu Asn 
    50                  55                  60                  


Leu Tyr Gln Xaa Tyr Phe Lys Arg Gln Arg His Glu Xaa Leu Leu Val 
65                  70                  75                  80  


Leu Val Val Phe Ala Ala Leu Phe Asp Cys Tyr Val Val Val Met Cys 
                85                  90                  95      


Ala Val Val Phe Ser Ser Asp Lys Leu Ala Ser Leu Ala Val Ala Gly 
            100                 105                 110         


<210> 1561
<211> 482
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<400> 1561
Met Pro Arg Asn Gln Gly Phe Ser Glu Pro Glu Tyr Ser Ala Glu Tyr 
1               5                   10                  15      


Ser Ala Glu Tyr Ser Val Ser Leu Pro Ser Asp Pro Asp Arg Gly Val 
            20                  25                  30          


Gly Arg Xaa His Glu Ile Ser Val Arg Asn Ser Gly Ser Cys Leu Cys 
        35                  40                  45              


Leu Pro Arg Phe Met Arg Leu Xaa Phe Val Pro Glu Ser Leu Glu Asn 
    50                  55                  60                  


Leu Tyr Gln Xaa Tyr Phe Lys Arg Gln Arg His Glu Xaa Leu Leu Val 
65                  70                  75                  80  


Leu Val Val Phe Ala Ala Leu Phe Asp Cys Tyr Val Val Val Met Cys 
                85                  90                  95      


Ala Val Val Phe Ser Ser Asp Lys Leu Ala Ser Leu Ala Val Ala Gly 
            100                 105                 110         


Ile Gly Leu Val Leu Asp Ile Ile Leu Phe Val Leu Cys Lys Lys Gly 
        115                 120                 125             


Leu Leu Pro Asp Arg Val Xaa Arg Arg Val Leu Pro Tyr Val Leu Trp 
    130                 135                 140                 


Leu Leu Ile Xaa Ala Gln Ile Phe Ser Tyr Leu Gly Leu Asn Phe Ala 
145                 150                 155                 160 


Arg Ala His Ala Ala Ser Asp Xaa Val Gly Trp Gln Val Phe Phe Val 
                165                 170                 175     


Phe Ser Phe Phe Ile Xaa Leu Pro Leu Ser Leu Ser Pro Ile Val Ile 
            180                 185                 190         


Ile Ser Val Val Ser Cys Val Val His Xaa Leu Val Leu Gly Val Xaa 
        195                 200                 205             


Val Ala Gln Gln Gln Gln Glu Glu Leu Lys Gly Met Gln Leu Leu Arg 
    210                 215                 220                 


Glu Glu Asn Leu Met Leu Ser Ile Leu Pro Lys His Val Ala Asp Glu 
225                 230                 235                 240 


Met Leu Lys Asp Met Lys Lys Asp Glu Ser Gln Lys Asp Gln Gln Gln 
                245                 250                 255     


Phe Asn Xaa Met Tyr Met Tyr Arg His Glu Asn Val Ser Ile Leu Phe 
            260                 265                 270         


Ala Asp Ile Val Gly Phe Xaa Gln Leu Ser Ser Ala Cys Ser Ala Gln 
        275                 280                 285             


Glu Leu Val Lys Leu Leu Asn Glu Leu Phe Ala Arg Phe Asp Lys Leu 
    290                 295                 300                 


Ala Ala Lys Tyr His Gln Leu Arg Ile Lys Ile Leu Gly Asp Cys Tyr 
305                 310                 315                 320 


Tyr Cys Ile Cys Gly Leu Pro Asp Tyr Arg Glu Asp His Ala Val Cys 
                325                 330                 335     


Ser Ile Leu Met Gly Leu Ala Met Val Glu Ala Ile Ser Tyr Val Arg 
            340                 345                 350         


Glu Lys Xaa Lys Xaa Gly Val Asp Met Arg Val Gly Val His Xaa Gly 
        355                 360                 365             


Xaa Val Leu Gly Gly Val Leu Gly Gln Lys Arg Trp Gln Tyr Asp Val 
    370                 375                 380                 


Trp Ser Xaa Asp Val Xaa Val Ala Asn Lys Met Glu Ala Gly Gly Ile 
385                 390                 395                 400 


Pro Gly Arg Val His Ile Ser Gln Ser Xaa Met Asp Cys Leu Lys Gly 
                405                 410                 415     


Glu Phe Asp Val Glu Pro Gly Asp Gly Gly Ser Arg Cys Asp Tyr Leu 
            420                 425                 430         


Glu Glu Lys Gly Ile Glu Xaa Tyr Leu Ile Ile Ala Ser Lys Pro Glu 
        435                 440                 445             


Val Lys Lys Xaa Ala Xaa Gln Asn Gly Leu Asn Gly Ser Ala Leu Pro 
    450                 455                 460                 


Asn Gly Ala Pro Ala Ser Ser Lys Ser Ser Ser Pro Ala Leu Ile Glu 
465                 470                 475                 480 


Xaa Lys 
        


<210> 1562
<211> 1144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<400> 1562
Met Pro Arg Asn Gln Gly Phe Ser Glu Pro Glu Tyr Ser Ala Glu Tyr 
1               5                   10                  15      


Ser Ala Glu Tyr Ser Val Ser Leu Pro Ser Asp Pro Asp Arg Gly Val 
            20                  25                  30          


Gly Arg Xaa His Glu Ile Ser Val Arg Asn Ser Gly Ser Cys Leu Cys 
        35                  40                  45              


Leu Pro Arg Phe Met Arg Leu Xaa Phe Val Pro Glu Ser Leu Glu Asn 
    50                  55                  60                  


Leu Tyr Gln Xaa Tyr Phe Lys Arg Gln Arg His Glu Xaa Leu Leu Val 
65                  70                  75                  80  


Leu Val Val Phe Ala Ala Leu Phe Asp Cys Tyr Val Val Val Met Cys 
                85                  90                  95      


Ala Val Val Phe Ser Ser Asp Lys Leu Ala Ser Leu Ala Val Ala Gly 
            100                 105                 110         


Ile Gly Leu Val Leu Asp Ile Ile Leu Phe Val Leu Cys Lys Lys Gly 
        115                 120                 125             


Leu Leu Pro Asp Arg Val Xaa Arg Arg Val Leu Pro Tyr Val Leu Trp 
    130                 135                 140                 


Leu Leu Ile Xaa Ala Gln Ile Phe Ser Tyr Leu Gly Leu Asn Phe Ala 
145                 150                 155                 160 


Arg Ala His Ala Ala Ser Asp Xaa Val Gly Trp Gln Val Phe Phe Val 
                165                 170                 175     


Phe Ser Phe Phe Ile Xaa Leu Pro Leu Ser Leu Ser Pro Ile Val Ile 
            180                 185                 190         


Ile Ser Val Val Ser Cys Val Val His Xaa Leu Val Leu Gly Val Xaa 
        195                 200                 205             


Val Ala Gln Gln Gln Gln Glu Glu Leu Lys Gly Met Gln Leu Leu Arg 
    210                 215                 220                 


Glu Ile Leu Ala Asn Val Phe Leu Tyr Leu Cys Ala Ile Ala Val Gly 
225                 230                 235                 240 


Ile Met Ser Tyr Tyr Met Ala Asp Arg Lys His Arg Lys Ala Phe Leu 
                245                 250                 255     


Glu Ala Arg Gln Ser Leu Glu Val Lys Met Asn Leu Glu Glu Gln Ser 
            260                 265                 270         


Gln Gln Gln Glu Asn Leu Met Leu Ser Ile Leu Pro Lys His Val Ala 
        275                 280                 285             


Asp Glu Met Leu Lys Asp Met Lys Lys Asp Glu Ser Gln Lys Asp Gln 
    290                 295                 300                 


Gln Gln Phe Asn Xaa Met Tyr Met Tyr Arg His Glu Asn Val Ser Ile 
305                 310                 315                 320 


Leu Phe Ala Asp Ile Val Gly Phe Xaa Gln Leu Ser Ser Ala Cys Ser 
                325                 330                 335     


Ala Gln Glu Leu Val Lys Leu Leu Asn Glu Leu Phe Ala Arg Phe Asp 
            340                 345                 350         


Lys Leu Ala Ala Lys Tyr His Gln Leu Arg Ile Lys Ile Leu Gly Asp 
        355                 360                 365             


Cys Tyr Tyr Cys Ile Cys Gly Leu Pro Asp Tyr Arg Glu Asp His Ala 
    370                 375                 380                 


Val Cys Ser Ile Leu Met Gly Leu Ala Met Val Glu Ala Ile Ser Tyr 
385                 390                 395                 400 


Val Arg Glu Lys Xaa Lys Xaa Gly Val Asp Met Arg Val Gly Val His 
                405                 410                 415     


Xaa Gly Xaa Val Leu Gly Gly Val Leu Gly Gln Lys Arg Trp Gln Tyr 
            420                 425                 430         


Asp Val Trp Ser Xaa Asp Val Xaa Val Ala Asn Lys Met Glu Ala Gly 
        435                 440                 445             


Gly Ile Pro Gly Arg Val His Ile Ser Gln Ser Xaa Met Asp Cys Leu 
    450                 455                 460                 


Lys Gly Glu Phe Asp Val Glu Pro Gly Asp Gly Gly Ser Arg Cys Asp 
465                 470                 475                 480 


Tyr Leu Glu Glu Lys Gly Ile Glu Xaa Tyr Leu Ile Ile Ala Ser Lys 
                485                 490                 495     


Pro Glu Val Lys Lys Xaa Ala Xaa Gln Asn Gly Leu Asn Gly Ser Ala 
            500                 505                 510         


Leu Pro Asn Gly Ala Pro Ala Ser Ser Lys Ser Ser Ser Pro Ala Leu 
        515                 520                 525             


Ile Glu Xaa Lys Glu Pro Asn Gly Ser Ala His Ser Ser Gly Ser Xaa 
    530                 535                 540                 


Ser Glu Lys Pro Glu Glu Gln Asp Ala Gln Ala Asp Asn Pro Ser Phe 
545                 550                 555                 560 


Pro Asn Pro Arg Arg Arg Leu Arg Leu Gln Asp Leu Ala Asp Arg Val 
                565                 570                 575     


Val Asp Ala Ser Glu Asp Glu His Glu Leu Asn Gln Leu Leu Asn Glu 
            580                 585                 590         


Ala Leu Leu Glu Arg Glu Ser Ala Gln Val Val Lys Lys Arg Asn Xaa 
        595                 600                 605             


Phe Leu Leu Ser Met Arg Phe Met Asp Pro Glu Met Glu Xaa Arg Tyr 
    610                 615                 620                 


Ser Val Glu Lys Glu Lys Gln Ser Gly Ala Ala Phe Ser Cys Ser Cys 
625                 630                 635                 640 


Val Val Leu Leu Cys Xaa Ala Leu Val Glu Ile Leu Ile Asp Pro Trp 
                645                 650                 655     


Leu Met Xaa Asn Tyr Val Xaa Phe Met Val Gly Glu Ile Leu Leu Leu 
            660                 665                 670         


Ile Leu Xaa Ile Cys Ser Leu Ala Ala Ile Phe Pro Arg Ala Phe Pro 
        675                 680                 685             


Lys Lys Leu Val Ala Phe Ser Xaa Trp Ile Asp Arg Xaa Arg Trp Ala 
    690                 695                 700                 


Arg Asn Xaa Trp Ala Met Leu Ala Ile Phe Ile Leu Val Met Ala Asn 
705                 710                 715                 720 


Val Val Asp Met Leu Ser Cys Leu Gln Tyr Tyr Xaa Gly Pro Ser Asn 
                725                 730                 735     


Ala Xaa Ala Gly Met Glu Xaa Glu Gly Ser Cys Leu Glu Asn Pro Lys 
            740                 745                 750         


Tyr Tyr Asn Tyr Val Ala Val Leu Ser Leu Ile Ala Xaa Ile Met Leu 
        755                 760                 765             


Val Gln Val Ser His Met Val Lys Leu Xaa Leu Met Leu Leu Val Ala 
    770                 775                 780                 


Gly Ala Val Ala Xaa Ile Asn Leu Tyr Ala Trp Arg Pro Val Phe Asp 
785                 790                 795                 800 


Glu Tyr Asp His Lys Arg Phe Arg Glu His Asp Leu Pro Met Val Ala 
                805                 810                 815     


Leu Glu Gln Met Gln Gly Phe Asn Pro Gly Leu Asn Gly Xaa Asp Arg 
            820                 825                 830         


Leu Pro Leu Val Pro Ser Lys Tyr Ser Met Xaa Val Met Val Phe Leu 
        835                 840                 845             


Met Met Leu Ser Phe Tyr Tyr Phe Ser Arg His Val Glu Lys Leu Ala 
    850                 855                 860                 


Arg Xaa Leu Phe Leu Trp Lys Ile Glu Val His Asp Gln Lys Glu Arg 
865                 870                 875                 880 


Val Tyr Glu Met Arg Arg Trp Asn Glu Ala Leu Val Xaa Asn Met Leu 
                885                 890                 895     


Pro Glu His Val Ala Arg His Phe Leu Gly Ser Lys Lys Arg Asp Glu 
            900                 905                 910         


Glu Leu Tyr Ser Gln Xaa Tyr Asp Glu Ile Gly Val Met Phe Ala Ser 
        915                 920                 925             


Leu Pro Asn Phe Ala Asp Phe Tyr Xaa Glu Glu Ser Ile Asn Asn Gly 
    930                 935                 940                 


Gly Ile Glu Cys Leu Arg Phe Leu Asn Glu Ile Ile Ser Asp Phe Asp 
945                 950                 955                 960 


Ser Leu Leu Asp Asn Pro Lys Phe Arg Val Ile Xaa Lys Ile Lys Xaa 
                965                 970                 975     


Ile Gly Ser Xaa Tyr Met Ala Ala Ser Gly Val Xaa Pro Asp Val Asn 
            980                 985                 990         


Xaa Asn Gly Phe Ala Ser Ser Asn  Lys Glu Asp Lys Ser  Glu Arg Glu 
        995                 1000                 1005             


Arg Trp  Gln His Leu Ala Asp  Leu Ala Asp Phe Ala  Leu Ala Met 
    1010                 1015                 1020             


Lys Asp  Xaa Leu Xaa Asn Ile  Asn Asn Gln Ser Phe  Asn Asn Phe 
    1025                 1030                 1035             


Met Leu  Arg Ile Gly Met Asn  Lys Gly Gly Val Leu  Ala Gly Val 
    1040                 1045                 1050             


Ile Gly  Ala Arg Lys Pro His  Tyr Asp Ile Trp Gly  Asn Xaa Val 
    1055                 1060                 1065             


Asn Val  Ala Ser Arg Met Glu  Ser Xaa Gly Val Met  Gly Asn Ile 
    1070                 1075                 1080             


Gln Val  Val Glu Glu Xaa Gln  Val Ile Leu Arg Glu  Tyr Gly Phe 
    1085                 1090                 1095             


Arg Phe  Val Arg Arg Gly Pro  Ile Phe Val Lys Gly  Lys Gly Glu 
    1100                 1105                 1110             


Leu Leu  Xaa Phe Phe Leu Lys  Gly Arg Asp Lys Leu  Ala Xaa Phe 
    1115                 1120                 1125             


Pro Asn  Gly Pro Ser Val Xaa  Leu Pro His Gln Val  Val Asp Asn 
    1130                 1135                 1140             


Ser 
    


<210> 1563
<211> 1145
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1117)..(1117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1128)..(1128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<400> 1563
Met Pro Arg Asn Gln Gly Phe Ser Glu Pro Glu Tyr Ser Ala Glu Tyr 
1               5                   10                  15      


Ser Ala Glu Tyr Ser Val Ser Leu Pro Ser Asp Pro Asp Arg Gly Val 
            20                  25                  30          


Gly Arg Xaa His Glu Ile Ser Val Arg Asn Ser Gly Ser Cys Leu Cys 
        35                  40                  45              


Leu Pro Arg Phe Met Arg Leu Xaa Phe Val Pro Glu Ser Leu Glu Asn 
    50                  55                  60                  


Leu Tyr Gln Xaa Tyr Phe Lys Arg Gln Arg His Glu Xaa Leu Leu Val 
65                  70                  75                  80  


Leu Val Val Phe Ala Ala Leu Phe Asp Cys Tyr Val Val Val Met Cys 
                85                  90                  95      


Ala Val Val Phe Ser Ser Asp Lys Leu Ala Ser Leu Ala Val Ala Gly 
            100                 105                 110         


Ile Gly Leu Val Leu Asp Ile Ile Leu Phe Val Leu Cys Lys Lys Gly 
        115                 120                 125             


Leu Leu Pro Asp Arg Val Xaa Arg Arg Val Leu Pro Tyr Val Leu Trp 
    130                 135                 140                 


Leu Leu Ile Xaa Ala Gln Ile Phe Ser Tyr Leu Gly Leu Asn Phe Ala 
145                 150                 155                 160 


Arg Ala His Ala Ala Ser Asp Xaa Val Gly Trp Gln Val Phe Phe Val 
                165                 170                 175     


Phe Ser Phe Phe Ile Xaa Leu Pro Leu Ser Leu Ser Pro Ile Val Ile 
            180                 185                 190         


Ile Ser Val Val Ser Cys Val Val His Xaa Leu Val Leu Gly Val Xaa 
        195                 200                 205             


Val Ala Gln Gln Gln Gln Glu Glu Leu Lys Gly Met Gln Leu Leu Arg 
    210                 215                 220                 


Glu Ile Leu Ala Asn Val Phe Leu Tyr Leu Cys Ala Ile Ala Val Gly 
225                 230                 235                 240 


Ile Met Ser Tyr Tyr Met Ala Asp Arg Lys His Arg Lys Ala Phe Leu 
                245                 250                 255     


Glu Ala Arg Gln Ser Leu Glu Val Lys Met Asn Leu Glu Glu Gln Ser 
            260                 265                 270         


Gln Gln Gln Glu Asn Leu Met Leu Ser Ile Leu Pro Lys His Val Ala 
        275                 280                 285             


Asp Glu Met Leu Lys Asp Met Lys Lys Asp Glu Ser Gln Lys Asp Gln 
    290                 295                 300                 


Gln Gln Phe Asn Xaa Met Tyr Met Tyr Arg His Glu Asn Val Ser Ile 
305                 310                 315                 320 


Leu Phe Ala Asp Ile Val Gly Phe Xaa Gln Leu Ser Ser Ala Cys Ser 
                325                 330                 335     


Ala Gln Glu Leu Val Lys Leu Leu Asn Glu Leu Phe Ala Arg Phe Asp 
            340                 345                 350         


Lys Leu Ala Ala Lys Tyr His Gln Leu Arg Ile Lys Ile Leu Gly Asp 
        355                 360                 365             


Cys Tyr Tyr Cys Ile Cys Gly Leu Pro Asp Tyr Arg Glu Asp His Ala 
    370                 375                 380                 


Val Cys Ser Ile Leu Met Gly Leu Ala Met Val Glu Ala Ile Ser Tyr 
385                 390                 395                 400 


Val Arg Glu Lys Xaa Lys Xaa Gly Val Asp Met Arg Val Gly Val His 
                405                 410                 415     


Xaa Gly Xaa Val Leu Gly Gly Val Leu Gly Gln Lys Arg Trp Gln Tyr 
            420                 425                 430         


Asp Val Trp Ser Xaa Asp Val Xaa Val Ala Asn Lys Met Glu Ala Gly 
        435                 440                 445             


Gly Ile Pro Gly Arg Val His Ile Ser Gln Ser Xaa Met Asp Cys Leu 
    450                 455                 460                 


Lys Gly Glu Phe Asp Val Glu Pro Gly Asp Gly Gly Ser Arg Cys Asp 
465                 470                 475                 480 


Tyr Leu Glu Glu Lys Gly Ile Glu Xaa Tyr Leu Ile Ile Ala Ser Lys 
                485                 490                 495     


Pro Glu Val Lys Lys Xaa Ala Xaa Gln Asn Gly Leu Asn Gly Ser Ala 
            500                 505                 510         


Leu Pro Asn Gly Ala Pro Ala Ser Ser Lys Ser Ser Ser Pro Ala Leu 
        515                 520                 525             


Ile Glu Xaa Lys Glu Pro Asn Gly Ser Ala His Ser Ser Gly Ser Xaa 
    530                 535                 540                 


Ser Glu Lys Pro Glu Glu Gln Asp Ala Gln Ala Asp Asn Pro Ser Phe 
545                 550                 555                 560 


Pro Asn Pro Arg Arg Arg Leu Arg Leu Gln Asp Leu Ala Asp Arg Val 
                565                 570                 575     


Val Asp Ala Ser Glu Asp Glu His Glu Leu Asn Gln Leu Leu Asn Glu 
            580                 585                 590         


Ala Leu Leu Glu Arg Glu Ser Ala Gln Val Val Lys Lys Arg Asn Xaa 
        595                 600                 605             


Phe Leu Leu Ser Met Arg Phe Met Asp Pro Glu Met Glu Xaa Arg Tyr 
    610                 615                 620                 


Ser Val Glu Lys Glu Lys Gln Ser Gly Ala Ala Phe Ser Cys Ser Cys 
625                 630                 635                 640 


Val Val Leu Leu Cys Xaa Ala Leu Val Glu Ile Leu Ile Asp Pro Trp 
                645                 650                 655     


Leu Met Xaa Asn Tyr Val Xaa Phe Met Val Gly Glu Ile Leu Leu Leu 
            660                 665                 670         


Ile Leu Xaa Ile Cys Ser Leu Ala Ala Ile Phe Pro Arg Ala Phe Pro 
        675                 680                 685             


Lys Lys Leu Val Ala Phe Ser Xaa Trp Ile Asp Arg Xaa Arg Trp Ala 
    690                 695                 700                 


Arg Asn Xaa Trp Ala Met Leu Ala Ile Phe Ile Leu Val Met Ala Asn 
705                 710                 715                 720 


Val Val Asp Met Leu Ser Cys Leu Gln Tyr Tyr Xaa Gly Pro Ser Asn 
                725                 730                 735     


Ala Xaa Ala Gly Met Glu Xaa Glu Gly Ser Cys Leu Glu Asn Pro Lys 
            740                 745                 750         


Tyr Tyr Asn Tyr Val Ala Val Leu Ser Leu Ile Ala Xaa Ile Met Leu 
        755                 760                 765             


Val Gln Val Ser His Met Val Lys Leu Xaa Leu Met Leu Leu Val Ala 
    770                 775                 780                 


Gly Ala Val Ala Xaa Ile Asn Leu Tyr Ala Trp Arg Pro Val Phe Asp 
785                 790                 795                 800 


Glu Tyr Asp His Lys Arg Phe Arg Glu His Asp Leu Pro Met Val Ala 
                805                 810                 815     


Leu Glu Gln Met Gln Gly Phe Asn Pro Gly Leu Asn Gly Xaa Asp Ser 
            820                 825                 830         


Arg Leu Pro Leu Val Pro Ser Lys Tyr Ser Met Xaa Val Met Val Phe 
        835                 840                 845             


Leu Met Met Leu Ser Phe Tyr Tyr Phe Ser Arg His Val Glu Lys Leu 
    850                 855                 860                 


Ala Arg Xaa Leu Phe Leu Trp Lys Ile Glu Val His Asp Gln Lys Glu 
865                 870                 875                 880 


Arg Val Tyr Glu Met Arg Arg Trp Asn Glu Ala Leu Val Xaa Asn Met 
                885                 890                 895     


Leu Pro Glu His Val Ala Arg His Phe Leu Gly Ser Lys Lys Arg Asp 
            900                 905                 910         


Glu Glu Leu Tyr Ser Gln Xaa Tyr Asp Glu Ile Gly Val Met Phe Ala 
        915                 920                 925             


Ser Leu Pro Asn Phe Ala Asp Phe Tyr Xaa Glu Glu Ser Ile Asn Asn 
    930                 935                 940                 


Gly Gly Ile Glu Cys Leu Arg Phe Leu Asn Glu Ile Ile Ser Asp Phe 
945                 950                 955                 960 


Asp Ser Leu Leu Asp Asn Pro Lys Phe Arg Val Ile Xaa Lys Ile Lys 
                965                 970                 975     


Xaa Ile Gly Ser Xaa Tyr Met Ala Ala Ser Gly Val Xaa Pro Asp Val 
            980                 985                 990         


Asn Xaa Asn Gly Phe Ala Ser Ser  Asn Lys Glu Asp Lys  Ser Glu Arg 
        995                 1000                 1005             


Glu Arg  Trp Gln His Leu Ala  Asp Leu Ala Asp Phe  Ala Leu Ala 
    1010                 1015                 1020             


Met Lys  Asp Xaa Leu Xaa Asn  Ile Asn Asn Gln Ser  Phe Asn Asn 
    1025                 1030                 1035             


Phe Met  Leu Arg Ile Gly Met  Asn Lys Gly Gly Val  Leu Ala Gly 
    1040                 1045                 1050             


Val Ile  Gly Ala Arg Lys Pro  His Tyr Asp Ile Trp  Gly Asn Xaa 
    1055                 1060                 1065             


Val Asn  Val Ala Ser Arg Met  Glu Ser Xaa Gly Val  Met Gly Asn 
    1070                 1075                 1080             


Ile Gln  Val Val Glu Glu Xaa  Gln Val Ile Leu Arg  Glu Tyr Gly 
    1085                 1090                 1095             


Phe Arg  Phe Val Arg Arg Gly  Pro Ile Phe Val Lys  Gly Lys Gly 
    1100                 1105                 1110             


Glu Leu  Leu Xaa Phe Phe Leu  Lys Gly Arg Asp Lys  Leu Ala Xaa 
    1115                 1120                 1125             


Phe Pro  Asn Gly Pro Ser Val  Xaa Leu Pro His Gln  Val Val Asp 
    1130                 1135                 1140             


Asn Ser  
    1145 


<210> 1564
<211> 791
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<400> 1564
Gln Leu Ser Ser Ala Cys Ser Ala Gln Glu Leu Val Lys Leu Leu Asn 
1               5                   10                  15      


Glu Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala Lys Tyr His Gln Leu 
            20                  25                  30          


Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys Ile Cys Gly Leu Pro 
        35                  40                  45              


Asp Tyr Arg Glu Asp His Ala Val Cys Ser Ile Leu Met Gly Leu Ala 
    50                  55                  60                  


Met Val Glu Ala Ile Ser Tyr Val Arg Glu Lys Xaa Lys Xaa Gly Val 
65                  70                  75                  80  


Asp Met Arg Val Gly Val His Xaa Gly Xaa Val Leu Gly Gly Val Leu 
                85                  90                  95      


Gly Gln Lys Arg Trp Gln Tyr Asp Val Trp Ser Xaa Asp Val Xaa Val 
            100                 105                 110         


Ala Asn Lys Met Glu Ala Gly Gly Ile Pro Gly Gly Ser Lys Ile Glu 
        115                 120                 125             


Glu Arg Leu Tyr Ser Cys Val Val Ala Pro Xaa Leu Arg Leu Arg Trp 
    130                 135                 140                 


Glu Arg Val His Ile Ser Gln Ser Xaa Met Asp Cys Leu Lys Gly Glu 
145                 150                 155                 160 


Phe Asp Val Glu Pro Gly Asp Gly Gly Ser Arg Cys Asp Tyr Leu Glu 
                165                 170                 175     


Glu Lys Gly Ile Glu Xaa Tyr Leu Ile Ile Ala Ser Lys Pro Glu Val 
            180                 185                 190         


Lys Lys Xaa Ala Xaa Gln Asn Gly Leu Asn Gly Ser Ala Leu Pro Asn 
        195                 200                 205             


Gly Ala Pro Ala Ser Ser Lys Ser Ser Ser Pro Ala Leu Ile Glu Xaa 
    210                 215                 220                 


Lys Glu Pro Asn Gly Ser Ala His Ser Ser Gly Ser Xaa Ser Glu Lys 
225                 230                 235                 240 


Pro Glu Glu Gln Asp Ala Gln Ala Asp Asn Pro Ser Phe Pro Asn Pro 
                245                 250                 255     


Arg Arg Arg Leu Arg Leu Gln Asp Leu Ala Asp Arg Val Val Asp Ala 
            260                 265                 270         


Ser Glu Asp Glu His Glu Leu Asn Gln Leu Leu Asn Glu Ala Leu Leu 
        275                 280                 285             


Glu Arg Glu Ser Ala Gln Val Val Lys Lys Arg Asn Xaa Phe Leu Leu 
    290                 295                 300                 


Ser Met Arg Phe Met Asp Pro Glu Met Glu Xaa Arg Tyr Ser Val Glu 
305                 310                 315                 320 


Lys Glu Lys Gln Ser Gly Ala Ala Phe Ser Cys Ser Cys Val Val Leu 
                325                 330                 335     


Leu Cys Xaa Ala Leu Val Glu Ile Leu Ile Asp Pro Trp Leu Met Xaa 
            340                 345                 350         


Asn Tyr Val Xaa Phe Met Val Gly Glu Ile Leu Leu Leu Ile Leu Xaa 
        355                 360                 365             


Ile Cys Ser Leu Ala Ala Ile Phe Pro Arg Ala Phe Pro Lys Lys Leu 
    370                 375                 380                 


Val Ala Phe Ser Xaa Trp Ile Asp Arg Xaa Arg Trp Ala Arg Asn Xaa 
385                 390                 395                 400 


Trp Ala Met Leu Ala Ile Phe Ile Leu Val Met Ala Asn Val Val Asp 
                405                 410                 415     


Met Val Ser His Met Val Lys Leu Xaa Leu Met Leu Leu Val Ala Gly 
            420                 425                 430         


Ala Val Ala Xaa Ile Asn Leu Tyr Ala Trp Arg Pro Val Phe Asp Glu 
        435                 440                 445             


Tyr Asp His Lys Arg Phe Arg Glu His Asp Leu Pro Met Val Ala Leu 
    450                 455                 460                 


Glu Gln Met Gln Gly Phe Asn Pro Gly Leu Asn Gly Xaa Asp Arg Leu 
465                 470                 475                 480 


Pro Leu Val Pro Ser Lys Tyr Ser Met Xaa Val Met Val Phe Leu Met 
                485                 490                 495     


Met Leu Ser Phe Tyr Tyr Phe Ser Arg His Val Glu Lys Leu Ala Arg 
            500                 505                 510         


Xaa Leu Phe Leu Trp Lys Ile Glu Val His Asp Gln Lys Glu Arg Val 
        515                 520                 525             


Tyr Glu Met Arg Arg Trp Asn Glu Ala Leu Val Xaa Asn Met Leu Pro 
    530                 535                 540                 


Glu His Val Ala Arg His Phe Leu Gly Ser Lys Lys Arg Asp Glu Glu 
545                 550                 555                 560 


Leu Tyr Ser Gln Xaa Tyr Asp Glu Ile Gly Val Met Phe Ala Ser Leu 
                565                 570                 575     


Pro Asn Phe Ala Asp Phe Tyr Xaa Glu Glu Ser Ile Asn Asn Gly Gly 
            580                 585                 590         


Ile Glu Cys Leu Arg Phe Leu Asn Glu Ile Ile Ser Asp Phe Asp Ser 
        595                 600                 605             


Leu Leu Asp Asn Pro Lys Phe Arg Val Ile Xaa Lys Ile Lys Xaa Ile 
    610                 615                 620                 


Gly Ser Xaa Tyr Met Ala Ala Ser Gly Val Xaa Pro Asp Val Asn Xaa 
625                 630                 635                 640 


Asn Gly Phe Ala Ser Ser Asn Lys Glu Asp Lys Ser Glu Arg Glu Arg 
                645                 650                 655     


Trp Gln His Leu Ala Asp Leu Ala Asp Phe Ala Leu Ala Met Lys Asp 
            660                 665                 670         


Xaa Leu Xaa Asn Ile Asn Asn Gln Ser Phe Asn Asn Phe Met Leu Arg 
        675                 680                 685             


Ile Gly Met Asn Lys Gly Gly Val Leu Ala Gly Val Ile Gly Ala Arg 
    690                 695                 700                 


Lys Pro His Tyr Asp Ile Trp Gly Asn Xaa Val Asn Val Ala Ser Arg 
705                 710                 715                 720 


Met Glu Ser Xaa Gly Val Met Gly Asn Ile Gln Val Val Glu Glu Xaa 
                725                 730                 735     


Gln Val Ile Leu Arg Glu Tyr Gly Phe Arg Phe Val Arg Arg Gly Pro 
            740                 745                 750         


Ile Phe Val Lys Gly Lys Gly Glu Leu Leu Xaa Phe Phe Leu Lys Gly 
        755                 760                 765             


Arg Asp Lys Leu Ala Xaa Phe Pro Asn Gly Pro Ser Val Xaa Leu Pro 
    770                 775                 780                 


His Gln Val Val Asp Asn Ser 
785                 790     


<210> 1565
<211> 198
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<400> 1565
Val Xaa Phe Met Val Gly Glu Ile Leu Leu Leu Ile Leu Xaa Ile Cys 
1               5                   10                  15      


Ser Leu Ala Ala Ile Phe Pro Arg Ala Phe Pro Lys Lys Leu Val Ala 
            20                  25                  30          


Phe Ser Xaa Trp Ile Asp Arg Xaa Arg Trp Ala Arg Asn Xaa Trp Ala 
        35                  40                  45              


Met Leu Ala Ile Phe Ile Leu Val Met Ala Asn Val Val Asp Met Leu 
    50                  55                  60                  


Ser Cys Leu Gln Tyr Tyr Xaa Gly Pro Ser Asn Ala Xaa Ala Gly Met 
65                  70                  75                  80  


Glu Xaa Glu Gly Ser Cys Leu Glu Asn Pro Lys Tyr Tyr Asn Tyr Val 
                85                  90                  95      


Ala Val Leu Ser Leu Ile Ala Xaa Ile Met Leu Val Gln Val Ser His 
            100                 105                 110         


Met Val Lys Leu Xaa Leu Met Leu Leu Val Ala Gly Ala Val Ala Xaa 
        115                 120                 125             


Ile Asn Leu Tyr Ala Trp Arg Pro Val Phe Asp Glu Tyr Asp His Lys 
    130                 135                 140                 


Arg Phe Arg Glu His Asp Leu Pro Met Val Ala Leu Glu Gln Met Gln 
145                 150                 155                 160 


Gly Phe Asn Pro Gly Leu Asn Gly Xaa Asp Ser Arg Leu Pro Leu Val 
                165                 170                 175     


Pro Ser Lys Tyr Ser Met Xaa Val Met Val Phe Leu Met Met Leu Ser 
            180                 185                 190         


Phe Tyr Tyr Phe Ser Arg 
        195             


<210> 1566
<211> 49
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<400> 1566
Xaa Tyr Asp Ile Trp Gly Asn Xaa Val Asn Val Ala Ser Arg Met Glu 
1               5                   10                  15      


Ser Xaa Gly Val Met Gly Asn Ile Gln Trp Arg Leu Ala Glu Lys Leu 
            20                  25                  30          


His Glu Arg Gly Lys Gly Xaa Glu Glu Gln Ala Val Ala Val Ser Arg 
        35                  40                  45              


Trp 
    


<210> 1567
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 1567
Met Ala Arg Leu Phe Ser Pro Arg Pro Pro Pro Ser Glu Asp Leu Phe 
1               5                   10                  15      


Tyr Glu Xaa Tyr Tyr Ser Leu Ser Gln Gln Tyr Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Gly Ile Val Leu Cys Ala Leu Ala Ala Leu Leu Ala Val Ala 
        35                  40                  45              


Trp Ala Ser Gly Arg Glu Leu Xaa Ser Asp Pro Ser Phe Leu Xaa Xaa 
    50                  55                  60                  


Val Leu Cys Ala Leu Gly Gly Phe Ser Leu Leu Leu Gly Leu Ala Ser 
65                  70                  75                  80  


Arg Glu Gln Arg Leu Gln Arg Trp Xaa Arg Pro Leu Ser Gly Leu Val 
                85                  90                  95      


Trp Val Ala Leu Leu Ala Leu Gly His Ala Phe Leu Phe Xaa Gly Gly 
            100                 105                 110         


Val Val Ser 
        115 


<210> 1568
<211> 449
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<400> 1568
Met Ala Arg Leu Phe Ser Pro Arg Pro Pro Pro Ser Glu Asp Leu Phe 
1               5                   10                  15      


Tyr Glu Xaa Tyr Tyr Ser Leu Ser Gln Gln Tyr Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Gly Ile Val Leu Cys Ala Leu Ala Ala Leu Leu Ala Val Ala 
        35                  40                  45              


Trp Ala Ser Gly Arg Glu Leu Xaa Ser Asp Pro Ser Phe Leu Xaa Xaa 
    50                  55                  60                  


Val Leu Cys Ala Leu Gly Gly Phe Ser Leu Leu Leu Gly Leu Ala Ser 
65                  70                  75                  80  


Arg Glu Gln Arg Leu Gln Arg Trp Xaa Arg Pro Leu Ser Gly Leu Val 
                85                  90                  95      


Trp Val Ala Leu Leu Ala Leu Gly His Ala Phe Leu Phe Xaa Gly Gly 
            100                 105                 110         


Val Val Ser Ala Trp Asp Gln Val Ser Tyr Phe Leu Phe Val Ile Phe 
        115                 120                 125             


Xaa Ala Tyr Ala Met Leu Pro Leu Gly Met Arg Asp Ala Ala Val Ala 
    130                 135                 140                 


Gly Leu Ala Ser Ser Leu Ser His Leu Leu Val Leu Gly Leu Tyr Leu 
145                 150                 155                 160 


Gly Pro Gln Pro Asp Ser Arg Pro Ala Leu Leu Pro Gln Leu Ala Ala 
                165                 170                 175     


Asn Ala Val Leu Phe Leu Cys Gly Asn Val Ala Gly Val Tyr His Lys 
            180                 185                 190         


Ala Leu Met Glu Arg Ala Leu Arg Ala Xaa Phe Arg Glu Ala Leu Ser 
        195                 200                 205             


Ser Leu His Ser Arg Arg Arg Leu Asp Xaa Glu Lys Lys His Gln Glu 
    210                 215                 220                 


His Leu Leu Leu Ser Ile Leu Pro Ala Tyr Leu Ala Arg Glu Met Lys 
225                 230                 235                 240 


Ala Glu Ile Met Ala Arg Leu Gln Ala Gly Gln Gly Ser Arg Pro Glu 
                245                 250                 255     


Ser Xaa Asn Asn Phe His Ser Leu Tyr Val Lys Arg His Gln Gly Val 
            260                 265                 270         


Ser Val Leu Tyr Ala Asp Ile Val Gly Phe Xaa Arg Leu Ala Ser Glu 
        275                 280                 285             


Cys Ser Pro Lys Glu Leu Val Leu Met Leu Asn Glu Leu Phe Gly Lys 
    290                 295                 300                 


Phe Asp Gln Ile Ala Lys Val Pro Leu His Xaa His Ile His Xaa Pro 
305                 310                 315                 320 


Arg Ser Met Asn Ala Cys Gly Ser Arg Ser Trp Gly Xaa Val Xaa Xaa 
                325                 330                 335     


Val Ser Leu Gly Cys His Ser His Cys Gln Xaa Met Pro Ser Xaa Ala 
            340                 345                 350         


Cys Ala Trp Ala Trp Xaa Cys Ala Gly Pro Ser Gly Asn Cys Gly Gln 
        355                 360                 365             


Pro Leu Ala Trp Xaa Ser Xaa Cys Val Trp Ala Cys Xaa Gln Ala Ala 
    370                 375                 380                 


Tyr Cys Val Glu Ser Ser Gly Cys Arg Ser Gly Ser Xaa Xaa Phe Gly 
385                 390                 395                 400 


His Met Met Ser His Trp Leu Xaa Xaa Trp Arg Gln Ala Val Tyr Gln 
                405                 410                 415     


Gly Glu Cys Xaa Ser Gln Gly Leu Pro Trp Pro Cys Trp Gln Gly Leu 
            420                 425                 430         


Met Leu Trp Arg Xaa Gln Ala Trp Ser Ile Gly Xaa Pro Xaa Phe Gly 
        435                 440                 445             


Ser 
    


<210> 1569
<211> 1077
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<400> 1569
Met Ala Arg Leu Phe Ser Pro Arg Pro Pro Pro Ser Glu Asp Leu Phe 
1               5                   10                  15      


Tyr Glu Xaa Tyr Tyr Ser Leu Ser Gln Gln Tyr Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Gly Ile Val Leu Cys Ala Leu Ala Ala Leu Leu Ala Val Ala 
        35                  40                  45              


Trp Ala Ser Gly Arg Glu Leu Xaa Ser Asp Pro Ser Phe Leu Xaa Xaa 
    50                  55                  60                  


Val Leu Cys Ala Leu Gly Gly Phe Ser Leu Leu Leu Gly Leu Ala Ser 
65                  70                  75                  80  


Arg Glu Gln Arg Leu Gln Arg Trp Xaa Arg Pro Leu Ser Gly Leu Val 
                85                  90                  95      


Trp Val Ala Leu Leu Ala Leu Gly His Ala Phe Leu Phe Xaa Gly Gly 
            100                 105                 110         


Val Val Ser Ala Trp Asp Gln Val Ser Tyr Phe Leu Phe Val Ile Phe 
        115                 120                 125             


Xaa Ala Tyr Ala Met Leu Pro Leu Gly Met Arg Asp Ala Ala Val Ala 
    130                 135                 140                 


Gly Leu Ala Ser Ser Leu Ser His Leu Leu Val Leu Gly Leu Tyr Leu 
145                 150                 155                 160 


Gly Pro Gln Pro Asp Ser Arg Pro Ala Leu Leu Pro Gln Leu Ala Ala 
                165                 170                 175     


Asn Ala Val Leu Phe Leu Cys Gly Asn Val Ala Gly Val Tyr His Lys 
            180                 185                 190         


Ala Leu Met Glu Arg Ala Leu Arg Ala Xaa Phe Arg Glu Ala Leu Ser 
        195                 200                 205             


Ser Leu His Ser Arg Arg Arg Leu Asp Xaa Glu Lys Lys His Gln Glu 
    210                 215                 220                 


His Leu Leu Leu Ser Ile Leu Pro Ala Tyr Leu Ala Arg Glu Met Lys 
225                 230                 235                 240 


Ala Glu Ile Met Ala Arg Leu Gln Ala Gly Gln Gly Ser Arg Pro Glu 
                245                 250                 255     


Ser Xaa Asn Asn Phe His Ser Leu Tyr Val Lys Arg His Gln Gly Val 
            260                 265                 270         


Ser Val Leu Tyr Ala Asp Ile Val Gly Phe Xaa Arg Leu Ala Ser Glu 
        275                 280                 285             


Cys Ser Pro Lys Glu Leu Val Leu Met Leu Asn Glu Leu Phe Gly Lys 
    290                 295                 300                 


Phe Asp Gln Ile Ala Lys Glu His Glu Cys Met Arg Ile Lys Ile Leu 
305                 310                 315                 320 


Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu Pro Leu Ser Leu Pro Asp 
                325                 330                 335     


His Ala Ile Asn Cys Val Arg Met Gly Leu Asp Met Cys Arg Ala Ile 
            340                 345                 350         


Arg Lys Leu Arg Ala Ala Xaa Gly Val Asp Ile Asn Met Arg Val Gly 
        355                 360                 365             


Val His Ser Gly Ser Val Leu Cys Gly Val Ile Gly Leu Gln Lys Trp 
    370                 375                 380                 


Gln Tyr Asp Val Trp Ser His Asp Val Xaa Leu Ala Asn His Met Glu 
385                 390                 395                 400 


Ala Gly Gly Val Pro Gly Arg Val His Ile Xaa Gly Ala Xaa Leu Ala 
                405                 410                 415     


Leu Leu Ala Gly Ala Tyr Ala Val Glu Asp Ala Gly Met Glu His Arg 
            420                 425                 430         


Asp Pro Tyr Leu Arg Glu Leu Gly Glu Pro Xaa Tyr Leu Val Ile Asp 
        435                 440                 445             


Pro Arg Ala Glu Glu Glu Asp Glu Lys Gly Xaa Ala Gly Gly Leu Leu 
    450                 455                 460                 


Ser Ser Leu Glu Gly Leu Lys Met Arg Pro Ser Leu Leu Met Xaa Arg 
465                 470                 475                 480 


Tyr Leu Glu Ser Trp Gly Ala Ala Lys Pro Phe Ala His Leu Ser His 
                485                 490                 495     


Gly Asp Ser Pro Val Ser Xaa Ser Xaa Pro Leu Pro Glu Lys Xaa Leu 
            500                 505                 510         


Ala Ser Phe Ser Xaa Gln Trp Ser Leu Asp Arg Ser Arg Xaa Pro Arg 
        515                 520                 525             


Gly Leu Asp Asp Glu Leu Asp Xaa Gly Asp Ala Lys Phe Phe Gln Val 
    530                 535                 540                 


Ile Glu Gln Leu Asn Ser Gln Lys Gln Trp Lys Gln Ser Lys Asp Phe 
545                 550                 555                 560 


Asn Pro Leu Xaa Leu Tyr Phe Arg Glu Lys Glu Met Glu Lys Glu Tyr 
                565                 570                 575     


Arg Leu Ser Ala Ile Pro Ala Phe Lys Tyr Tyr Glu Ala Cys Xaa Phe 
            580                 585                 590         


Leu Val Phe Leu Ser Asn Phe Ile Ile Gln Met Leu Val Xaa Asn Arg 
        595                 600                 605             


Pro Pro Ala Leu Ala Ile Xaa Tyr Ser Ile Xaa Phe Leu Leu Phe Leu 
    610                 615                 620                 


Leu Ile Leu Phe Val Cys Phe Ser Glu Asp Leu Met Arg Cys Val Leu 
625                 630                 635                 640 


Lys Gly Pro Lys Met Leu His Trp Leu Pro Ala Leu Ser Gly Leu Val 
                645                 650                 655     


Ala Xaa Arg Pro Gly Leu Arg Ile Ala Leu Gly Xaa Ala Xaa Ile Leu 
            660                 665                 670         


Leu Val Phe Ala Met Ala Ile Xaa Ser Leu Phe Phe Phe Pro Xaa Ser 
        675                 680                 685             


Ser Asp Cys Pro Phe Gln Ala Pro Asn Val Ser Ser Met Ile Ser Asn 
    690                 695                 700                 


Leu Ser Trp Glu Leu Pro Gly Ser Leu Pro Leu Ile Ser Val Pro Tyr 
705                 710                 715                 720 


Ser Met His Cys Cys Xaa Leu Gly Phe Leu Ser Cys Ser Leu Phe Leu 
                725                 730                 735     


His Met Ser Phe Glu Leu Lys Leu Leu Leu Leu Leu Leu Trp Leu Ala 
            740                 745                 750         


Ala Ser Cys Ser Leu Phe Leu His Ser His Ala Trp Leu Ser Glu Cys 
        755                 760                 765             


Leu Ile Val Arg Leu Tyr Leu Gly Pro Leu Asp Ser Arg Pro Gly Val 
    770                 775                 780                 


Leu Lys Glu Pro Lys Leu Met Gly Ala Ile Ser Phe Phe Ile Phe Phe 
785                 790                 795                 800 


Phe Xaa Leu Leu Val Leu Ala Arg Gln Asn Glu Tyr Tyr Cys Arg Leu 
                805                 810                 815     


Asp Phe Leu Trp Lys Lys Lys Leu Arg Gln Glu Arg Glu Glu Xaa Glu 
            820                 825                 830         


Xaa Met Glu Asn Leu Xaa Arg Leu Leu Leu Glu Asn Val Leu Pro Ala 
        835                 840                 845             


His Val Ala Pro Gln Phe Ile Gly Gln Asn Arg Arg Asn Glu Asp Leu 
    850                 855                 860                 


Tyr His Gln Ser Tyr Glu Cys Val Cys Val Leu Phe Ala Ser Val Pro 
865                 870                 875                 880 


Asp Phe Lys Glu Phe Tyr Ser Glu Ser Asn Ile Asn His Glu Gly Leu 
                885                 890                 895     


Glu Cys Leu Arg Leu Leu Asn Glu Ile Ile Ala Asp Phe Asp Glu Leu 
            900                 905                 910         


Leu Ser Lys Pro Lys Phe Ser Gly Val Glu Lys Ile Lys Xaa Ile Gly 
        915                 920                 925             


Ser Xaa Tyr Met Ala Ala Xaa Gly Leu Asn Ala Xaa Ser Gly Gln Asp 
    930                 935                 940                 


Ala Gln Gln Asp Ala Glu Arg Ser Cys Ser His Leu Gly Xaa Met Val 
945                 950                 955                 960 


Glu Phe Ala Val Ala Leu Gly Ser Lys Leu Asp Val Ile Asn Lys His 
                965                 970                 975     


Ser Phe Asn Asn Phe Arg Leu Arg Val Gly Leu Asn His Gly Pro Val 
            980                 985                 990         


Val Ala Gly Val Ile Gly Ala Gln  Lys Pro Gln Tyr Asp  Ile Trp Gly 
        995                 1000                 1005             


Asn Xaa  Val Asn Val Ala Ser  Arg Met Glu Ser Xaa  Gly Val Leu 
    1010                 1015                 1020             


Gly Lys  Ile Gln Val Xaa Glu  Glu Xaa Ala Trp Ala  Leu Gln Ser 
    1025                 1030                 1035             


Leu Gly  Tyr Xaa Cys Tyr Ser  Arg Gly Val Ile Lys  Val Lys Gly 
    1040                 1045                 1050             


Lys Gly  Gln Leu Cys Xaa Tyr  Phe Leu Asn Xaa Asp  Leu Xaa Arg 
    1055                 1060                 1065             


Xaa Gly  Pro Pro Ser Ala Xaa  Leu Gly 
    1070                 1075         


<210> 1570
<211> 36
<212> PRT
<213> Homo sapiens

<400> 1570
Met Leu Pro Leu Gly Met Arg Asp Ala Ala Val Ala Gly Leu Ala Ser 
1               5                   10                  15      


Ser Leu Ser His Leu Leu Val Leu Gly Leu Tyr Leu Gly Pro Gln Pro 
            20                  25                  30          


Asp Ser Arg Pro 
        35      


<210> 1571
<211> 216
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<400> 1571
Met Leu Pro Leu Gly Met Arg Asp Ala Ala Val Ala Gly Leu Ala Ser 
1               5                   10                  15      


Ser Leu Ser His Leu Leu Val Leu Gly Leu Tyr Leu Gly Pro Gln Pro 
            20                  25                  30          


Asp Ser Arg Pro Ala Leu Leu Pro Gln Leu Ala Ala Asn Ala Val Leu 
        35                  40                  45              


Phe Leu Cys Gly Asn Val Ala Gly Val Tyr His Lys Ala Leu Met Glu 
    50                  55                  60                  


Arg Ala Leu Arg Ala Xaa Phe Arg Glu Ala Leu Ser Ser Leu His Ser 
65                  70                  75                  80  


Arg Arg Arg Leu Asp Xaa Glu Lys Lys His Gln Glu His Leu Leu Leu 
                85                  90                  95      


Ser Ile Leu Pro Ala Tyr Leu Ala Arg Glu Met Lys Ala Glu Ile Met 
            100                 105                 110         


Ala Arg Leu Gln Ala Gly Gln Gly Ser Arg Pro Glu Ser Xaa Asn Asn 
        115                 120                 125             


Phe His Ser Leu Tyr Val Lys Arg His Gln Gly Val Ser Val Leu Tyr 
    130                 135                 140                 


Ala Asp Ile Val Gly Phe Xaa Arg Leu Ala Ser Glu Cys Ser Pro Lys 
145                 150                 155                 160 


Glu Leu Val Leu Met Leu Asn Glu Leu Phe Gly Lys Phe Asp Gln Ile 
                165                 170                 175     


Ala Lys Glu Xaa Ala Gly Ser His Trp Arg Gly His Gln His Ala Cys 
            180                 185                 190         


Gly Arg Ala Leu Arg Gln Arg Xaa Val Trp Ser His Arg Ala Ala Glu 
        195                 200                 205             


Val Ala Val Arg Arg Leu Val Xaa 
    210                 215     


<210> 1572
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 1572
Xaa Met Glu His Arg Asp Pro Tyr Leu Arg Glu Leu Gly Glu Pro Xaa 
1               5                   10                  15      


Tyr Leu Val Ile Asp Pro Arg Ala Glu Glu Glu Asp Glu Lys Gly Xaa 
            20                  25                  30          


Ala Gly Gly Leu Leu Ser Ser Leu Glu Gly Leu Lys Met Arg Pro Ser 
        35                  40                  45              


Leu Leu Met Xaa Arg Tyr Leu Glu Ser Trp Gly Ala Ala Lys Pro Phe 
    50                  55                  60                  


Ala His Leu Ser His Gly Asp Ser Pro Val Ser Xaa Ser Xaa Pro Leu 
65                  70                  75                  80  


Pro Glu Lys Xaa Leu Ala Ser Phe Ser Xaa Gln Trp Ser Leu Asp Arg 
                85                  90                  95      


Ser Arg Xaa Pro Arg Gly Leu Asp Asp Glu Leu Asp Xaa Gly Asp Ala 
            100                 105                 110         


Lys Phe Phe Gln Xaa Val Glu Ala Val Glu Gly Leu Gln Pro Xaa Asp 
        115                 120                 125             


Xaa Val Leu Gln Arg Glu Gly Asp Gly 
    130                 135         


<210> 1573
<211> 919
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<400> 1573
Met Ala Pro Ser Arg Phe Arg Xaa Gln Leu Glu Leu Val Ser Asn Val 
1               5                   10                  15      


Leu Ile Phe Ser Cys Xaa Asn Ile Val Gly Val Cys Xaa His Tyr Pro 
            20                  25                  30          


Ala Glu Val Ser Gln Arg Gln Ala Phe Gln Glu Xaa Arg Glu Cys Ile 
        35                  40                  45              


Gln Ala Arg Leu His Ser Gln Arg Glu Asn Gln Gln Gln Glu Arg Leu 
    50                  55                  60                  


Leu Leu Ser Val Leu Pro Arg His Val Ala Met Glu Met Lys Ala Asp 
65                  70                  75                  80  


Ile Asn Ala Lys Gln Glu Asp Met Met Phe His Lys Ile Tyr Ile Gln 
                85                  90                  95      


Lys His Asp Asn Val Ser Ile Leu Phe Ala Asp Ile Glu Gly Phe Xaa 
            100                 105                 110         


Ser Leu Ala Ser Gln Cys Xaa Ala Gln Glu Leu Val Met Xaa Leu Asn 
        115                 120                 125             


Glu Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala Glu Asn His Cys Leu 
    130                 135                 140                 


Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu Pro 
145                 150                 155                 160 


Glu Ala Arg Ala Asp His Ala His Cys Cys Val Glu Met Gly Met Asp 
                165                 170                 175     


Met Ile Glu Ala Ile Ser Leu Val Arg Glu Val Xaa Gly Val Asn Val 
            180                 185                 190         


Asn Met Arg Val Gly Ile His Ser Gly Arg Val His Cys Gly Val Leu 
        195                 200                 205             


Gly Leu Arg Lys Trp Gln Phe Asp Val Trp Ser Asn Asp Val Xaa Leu 
    210                 215                 220                 


Ala Asn His Met Glu Ala Gly Gly Lys Ala Gly Arg Ile His Ile Xaa 
225                 230                 235                 240 


Lys Ala Xaa Leu Asn Tyr Leu Asn Gly Asp Tyr Glu Val Glu Pro Gly 
                245                 250                 255     


Cys Gly Gly Glu Arg Asn Ala Tyr Leu Lys Glu His Ser Ile Glu Xaa 
            260                 265                 270         


Phe Leu Ile Leu Arg Cys Xaa Gln Lys Arg Lys Glu Glu Lys Ala Met 
        275                 280                 285             


Ile Ala Lys Met Asn Arg Gln Arg Xaa Asn Ser Ile Gly His Asn Pro 
    290                 295                 300                 


Pro His Trp Gly Ala Glu Arg Pro Phe Tyr Asn His Leu Gly Gly Asn 
305                 310                 315                 320 


Gln Val Ser Lys Glu Met Lys Arg Met Gly Phe Glu Asp Pro Lys Asp 
                325                 330                 335     


Lys Asn Ala Gln Glu Ser Ala Asn Pro Glu Asp Glu Val Asp Glu Phe 
            340                 345                 350         


Leu Gly Arg Ala Ile Asp Ala Arg Ser Ile Asp Arg Leu Arg Ser Glu 
        355                 360                 365             


His Val Arg Lys Phe Leu Leu Xaa Phe Arg Glu Pro Asp Leu Glu Lys 
    370                 375                 380                 


Lys Tyr Ser Lys Gln Val Asp Asp Arg Phe Gly Ala Tyr Val Ala Cys 
385                 390                 395                 400 


Ala Ser Leu Val Phe Leu Phe Ile Cys Phe Val Gln Ile Xaa Ile Val 
                405                 410                 415     


Pro His Ser Ile Phe Met Leu Ser Phe Tyr Leu Xaa Cys Ser Leu Leu 
            420                 425                 430         


Leu Xaa Leu Val Val Phe Val Ser Val Ile Tyr Ser Cys Val Lys Leu 
        435                 440                 445             


Phe Pro Ser Pro Leu Gln Xaa Leu Ser Arg Lys Ile Val Arg Ser Lys 
    450                 455                 460                 


Met Asn Ser Xaa Leu Val Gly Val Phe Xaa Ile Xaa Leu Val Phe Leu 
465                 470                 475                 480 


Ala Ala Phe Val Asn Met Phe Xaa Cys Asn Ser Arg Asp Leu Leu Gly 
                485                 490                 495     


Cys Leu Ala Gln Glu His Asn Ile Ser Ala Ser Gln Val Asn Ala Cys 
            500                 505                 510         


His Val Ala Glu Ser Ala Val Asn Tyr Ser Leu Gly Asp Glu Gln Gly 
        515                 520                 525             


Phe Cys Gly Ser Pro Trp Pro Asn Cys Asn Phe Pro Glu Tyr Phe Xaa 
    530                 535                 540                 


Tyr Ser Val Leu Leu Ser Leu Leu Ala Cys Ser Val Phe Leu Gln Ile 
545                 550                 555                 560 


Ser Cys Ile Gly Lys Leu Val Leu Met Leu Ala Ile Glu Leu Ile Tyr 
                565                 570                 575     


Val Leu Ile Val Glu Val Pro Gly Val Xaa Leu Phe Asp Asn Ala Asp 
            580                 585                 590         


Leu Leu Val Xaa Ala Asn Ala Ile Asp Phe Phe Asn Asn Gly Xaa Ser 
        595                 600                 605             


Gln Trp Ser Leu Cys Glu Asn Leu Arg His Arg Arg Met Glu Ala Gly 
    610                 615                 620                 


Xaa Tyr Phe Pro Ser Gly Val Lys Glu Gln Ser Pro Glu His Ala Xaa 
625                 630                 635                 640 


Lys Val Ala Leu Lys Val Val Xaa Pro Ile Ile Ile Ser Val Phe Val 
                645                 650                 655     


Leu Ala Leu Tyr Leu His Ala Gln Gln Val Glu Ser Xaa Ala Arg Leu 
            660                 665                 670         


Asp Phe Leu Trp Lys Leu Gln Ala Xaa Glu Glu Lys Glu Glu Met Glu 
        675                 680                 685             


Glu Leu Gln Ala Tyr Asn Arg Arg Leu Leu His Asn Ile Leu Pro Lys 
    690                 695                 700                 


Asp Val Ala Ala His Phe Leu Ala Arg Glu Arg Arg Asn Asp Glu Leu 
705                 710                 715                 720 


Tyr Tyr Gln Ser Cys Glu Cys Val Ala Val Met Phe Ala Ser Ile Ala 
                725                 730                 735     


Asn Phe Ser Glu Phe Tyr Val Glu Leu Glu Ala Asn Asn Glu Gly Val 
            740                 745                 750         


Glu Cys Leu Arg Leu Leu Asn Glu Ile Ile Ala Asp Phe Asp Glu Ile 
        755                 760                 765             


Ile Ser Glu Asp Arg Phe Arg Gln Leu Glu Lys Ile Lys Xaa Ile Gly 
    770                 775                 780                 


Ser Xaa Tyr Met Ala Ala Ser Gly Leu Asn Asp Ser Xaa Tyr Asp Lys 
785                 790                 795                 800 


Val Gly Lys Xaa His Ile Lys Ala Leu Ala Asp Phe Ala Met Lys Leu 
                805                 810                 815     


Met Asp Gln Met Lys Tyr Ile Asn Glu His Ser Phe Asn Asn Phe Gln 
            820                 825                 830         


Met Lys Ile Gly Leu Asn Ile Gly Pro Val Val Ala Gly Val Ile Gly 
        835                 840                 845             


Ala Arg Lys Pro Gln Tyr Asp Ile Trp Gly Asn Xaa Val Asn Val Ala 
    850                 855                 860                 


Ser Arg Met Asp Ser Xaa Gly Val Pro Asp Arg Ile Gln Val Xaa Xaa 
865                 870                 875                 880 


Asp Met Tyr Gln Val Leu Ala Ala Asn Xaa Tyr Gln Leu Glu Cys Arg 
                885                 890                 895     


Gly Val Val Lys Val Lys Gly Lys Gly Glu Met Met Xaa Tyr Phe Leu 
            900                 905                 910         


Asn Gly Gly Pro Pro Leu Ser 
        915                 


<210> 1574
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<400> 1574
Met Ala Pro Ser Arg Phe Arg Xaa Gln Leu Glu Val Ser Leu Ser Pro 
1               5                   10                  15      


Met Phe Ser Phe Ser Pro Ala Pro Xaa Ser Trp Val Ser Ala Pro Xaa 
            20                  25                  30          


Ile Arg Leu Arg Ser Pro Arg Asp Arg Leu Ser Arg Arg Pro Glu Ser 
        35                  40                  45              


Ala Ser Arg Arg Gly Ser Xaa Arg Ser Gly Arg Xaa Ser Ser Arg Asn 
    50                  55                  60                  


Gly Ser Cys Cys Leu Ser Phe Pro Val Met Leu Pro Trp Arg 
65                  70                  75              


<210> 1575
<211> 90
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 1575
Met Glu Met Lys Ala Asp Ile Asn Ala Lys Gln Glu Asp Met Met Phe 
1               5                   10                  15      


His Lys Ile Tyr Ile Gln Lys His Asp Asn Val Ser Ile Leu Phe Ala 
            20                  25                  30          


Asp Ile Glu Gly Phe Xaa Ser Leu Ala Ser Gln Cys Xaa Ala Gln Glu 
        35                  40                  45              


Leu Val Met Xaa Leu Asn Glu Leu Phe Ala Arg Phe Asp Lys Leu Ala 
    50                  55                  60                  


Ala Glu Asn His Cys Leu Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr 
65                  70                  75                  80  


Cys Val Ser Gly Leu Pro Glu Ala Arg Ala 
                85                  90  


<210> 1576
<211> 492
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<400> 1576
Met Glu Met Lys Ala Asp Ile Asn Ala Lys Gln Glu Asp Met Met Phe 
1               5                   10                  15      


His Lys Ile Tyr Ile Gln Lys His Asp Asn Val Ser Ile Leu Phe Ala 
            20                  25                  30          


Asp Ile Glu Gly Phe Xaa Ser Leu Ala Ser Gln Cys Xaa Ala Gln Glu 
        35                  40                  45              


Leu Val Met Xaa Leu Asn Glu Leu Phe Ala Arg Phe Asp Lys Leu Ala 
    50                  55                  60                  


Ala Glu Asn His Cys Leu Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr 
65                  70                  75                  80  


Cys Val Ser Gly Leu Pro Glu Ala Arg Ala Asp His Ala His Cys Cys 
                85                  90                  95      


Val Glu Met Gly Met Asp Met Ile Glu Ala Ile Ser Leu Val Arg Glu 
            100                 105                 110         


Val Xaa Gly Val Asn Val Asn Met Arg Val Gly Ile His Ser Gly Arg 
        115                 120                 125             


Val His Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Phe Asp Val Trp 
    130                 135                 140                 


Ser Asn Asp Val Xaa Leu Ala Asn His Met Glu Ala Gly Gly Lys Ala 
145                 150                 155                 160 


Gly Arg Ile His Ile Xaa Lys Ala Xaa Leu Asn Tyr Leu Asn Gly Asp 
                165                 170                 175     


Tyr Glu Val Glu Pro Gly Cys Gly Gly Glu Arg Asn Ala Tyr Leu Lys 
            180                 185                 190         


Glu His Ser Ile Glu Xaa Phe Leu Ile Leu Arg Cys Xaa Gln Lys Arg 
        195                 200                 205             


Lys Glu Glu Lys Ala Met Ile Ala Lys Met Asn Arg Gln Arg Xaa Asn 
    210                 215                 220                 


Ser Ile Gly His Asn Pro Pro His Trp Gly Ala Glu Arg Pro Phe Tyr 
225                 230                 235                 240 


Asn His Leu Gly Gly Asn Gln Val Ser Lys Glu Met Lys Arg Met Gly 
                245                 250                 255     


Phe Glu Asp Pro Lys Asp Lys Asn Ala Gln Glu Ser Ala Asn Pro Glu 
            260                 265                 270         


Asp Glu Val Asp Glu Phe Leu Gly Arg Ala Ile Asp Ala Arg Ser Ile 
        275                 280                 285             


Asp Arg Leu Arg Ser Glu His Val Arg Lys Phe Leu Leu Xaa Phe Arg 
    290                 295                 300                 


Glu Pro Asp Leu Glu Lys Lys Tyr Ser Lys Gln Val Asp Asp Arg Phe 
305                 310                 315                 320 


Gly Ala Tyr Val Ala Cys Ala Ser Leu Val Phe Leu Phe Ile Cys Phe 
                325                 330                 335     


Val Gln Ile Xaa Ile Val Pro His Ser Ile Phe Met Leu Ser Phe Tyr 
            340                 345                 350         


Leu Xaa Cys Ser Leu Leu Leu Xaa Leu Val Val Phe Val Ser Val Ile 
        355                 360                 365             


Tyr Ser Cys Val Lys Leu Phe Pro Ser Pro Leu Gln Xaa Leu Ser Arg 
    370                 375                 380                 


Lys Ile Val Arg Ser Lys Met Asn Ser Xaa Leu Val Gly Val Phe Xaa 
385                 390                 395                 400 


Ile Xaa Leu Val Phe Leu Ala Ala Phe Val Asn Met Phe Xaa Cys Asn 
                405                 410                 415     


Ser Arg Asp Leu Leu Gly Cys Leu Ala Gln Glu His Asn Ile Ser Ala 
            420                 425                 430         


Ser Gln Val Asn Ala Cys His Val Ala Glu Ser Ala Val Asn Tyr Ser 
        435                 440                 445             


Leu Gly Asp Glu Gln Gly Phe Cys Gly Ser Pro Trp Pro Asn Cys Asn 
    450                 455                 460                 


Phe Pro Glu Tyr Phe Xaa Tyr Ser Val Leu Leu Ser Leu Leu Ala Cys 
465                 470                 475                 480 


Ser Val Phe Leu Gln Ile Ser Cys Ile Gly Lys Leu 
                485                 490         


<210> 1577
<211> 911
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<400> 1577
Met Lys Ser Gln Lys Glu Gly Cys Cys Ser Arg Gly Asp Leu Ser Ile 
1               5                   10                  15      


Gln Xaa Gly Pro Gly Gly Glu Trp Ala Pro Arg Arg Leu Val Ser Asn 
            20                  25                  30          


Val Leu Ile Phe Ser Cys Xaa Asn Ile Val Gly Val Cys Xaa His Tyr 
        35                  40                  45              


Pro Ala Glu Val Ser Gln Arg Gln Ala Phe Gln Glu Xaa Arg Glu Cys 
    50                  55                  60                  


Ile Gln Ala Arg Leu His Ser Gln Arg Glu Asn Gln Gln Gln Glu Arg 
65                  70                  75                  80  


Leu Leu Leu Ser Val Leu Pro Arg His Val Ala Met Glu Met Lys Ala 
                85                  90                  95      


Asp Ile Asn Ala Lys Gln Glu Asp Met Met Phe His Lys Ile Tyr Ile 
            100                 105                 110         


Gln Lys His Asp Asn Val Ser Ile Leu Phe Ala Asp Ile Glu Gly Phe 
        115                 120                 125             


Xaa Ser Leu Ala Ser Gln Cys Xaa Ala Gln Glu Leu Val Met Xaa Leu 
    130                 135                 140                 


Asn Glu Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala Glu Asn His Cys 
145                 150                 155                 160 


Leu Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu 
                165                 170                 175     


Pro Glu Ala Arg Ala Asp His Ala His Cys Cys Val Glu Met Gly Met 
            180                 185                 190         


Asp Met Ile Glu Ala Ile Ser Leu Val Arg Glu Val Xaa Gly Val Asn 
        195                 200                 205             


Val Asn Met Arg Val Gly Ile His Ser Gly Arg Val His Cys Gly Val 
    210                 215                 220                 


Leu Gly Leu Arg Lys Trp Gln Phe Asp Val Trp Ser Asn Asp Val Xaa 
225                 230                 235                 240 


Leu Ala Asn His Met Glu Ala Gly Gly Lys Ala Gly Arg Ile His Ile 
                245                 250                 255     


Xaa Lys Ala Xaa Leu Asn Tyr Leu Asn Gly Asp Tyr Glu Val Glu Pro 
            260                 265                 270         


Gly Cys Gly Gly Glu Arg Asn Ala Tyr Leu Lys Glu His Ser Ile Glu 
        275                 280                 285             


Xaa Phe Leu Ile Leu Arg Cys Xaa Gln Lys Arg Lys Glu Glu Lys Ala 
    290                 295                 300                 


Met Ile Ala Lys Met Asn Arg Gln Arg Xaa Asn Ser Ile Gly His Asn 
305                 310                 315                 320 


Pro Pro His Trp Gly Ala Glu Arg Pro Phe Tyr Asn His Leu Gly Gly 
                325                 330                 335     


Asn Gln Val Ser Lys Glu Met Lys Arg Met Gly Phe Glu Asp Pro Lys 
            340                 345                 350         


Asp Lys Asn Ala Gln Glu Ser Ala Asn Pro Glu Asp Glu Val Asp Glu 
        355                 360                 365             


Phe Leu Gly Arg Ala Ile Asp Ala Arg Ser Ile Asp Arg Leu Arg Ser 
    370                 375                 380                 


Glu His Val Arg Lys Phe Leu Leu Xaa Phe Arg Glu Pro Asp Leu Glu 
385                 390                 395                 400 


Lys Lys Tyr Ser Lys Gln Val Asp Asp Arg Phe Gly Ala Tyr Val Ala 
                405                 410                 415     


Cys Ala Ser Leu Val Phe Leu Phe Ile Cys Phe Val Gln Ile Xaa Ile 
            420                 425                 430         


Val Pro His Ser Ile Phe Met Leu Ser Phe Tyr Leu Xaa Cys Ser Leu 
        435                 440                 445             


Leu Leu Xaa Leu Val Val Phe Val Ser Val Ile Tyr Ser Cys Val Lys 
    450                 455                 460                 


Leu Phe Pro Ser Pro Leu Gln Xaa Leu Ser Arg Lys Ile Val Arg Ser 
465                 470                 475                 480 


Lys Met Asn Ser Xaa Leu Val Gly Val Phe Xaa Ile Xaa Leu Val Phe 
                485                 490                 495     


Leu Ala Ala Phe Val Asn Met Phe Xaa Cys Asn Ser Arg Asp Leu Leu 
            500                 505                 510         


Gly Cys Leu Ala Gln Glu His Asn Ile Ser Ala Ser Gln Val Asn Ala 
        515                 520                 525             


Cys His Val Ala Glu Ser Ala Val Asn Tyr Ser Leu Gly Asp Glu Gln 
    530                 535                 540                 


Gly Phe Cys Gly Ser Pro Trp Pro Asn Cys Asn Phe Pro Glu Tyr Phe 
545                 550                 555                 560 


Xaa Tyr Ser Val Leu Leu Ser Leu Leu Ala Cys Ser Val Phe Leu Gln 
                565                 570                 575     


Ile Ser Cys Ile Gly Lys Leu Val Leu Met Leu Ala Ile Glu Leu Ile 
            580                 585                 590         


Tyr Val Leu Ile Val Glu Val Pro Gly Val Xaa Leu Phe Asp Asn Ala 
        595                 600                 605             


Asp Leu Leu Val Xaa Ala Asn Ala Ile Asp Phe Phe Asn Asn Gly Xaa 
    610                 615                 620                 


Ser Gln Cys Pro Glu His Ala Xaa Lys Val Ala Leu Lys Val Val Xaa 
625                 630                 635                 640 


Pro Ile Ile Ile Ser Val Phe Val Leu Ala Leu Tyr Leu His Ala Gln 
                645                 650                 655     


Gln Val Glu Ser Xaa Ala Arg Leu Asp Phe Leu Trp Lys Leu Gln Ala 
            660                 665                 670         


Xaa Glu Glu Lys Glu Glu Met Glu Glu Leu Gln Ala Tyr Asn Arg Arg 
        675                 680                 685             


Leu Leu His Asn Ile Leu Pro Lys Asp Val Ala Ala His Phe Leu Ala 
    690                 695                 700                 


Arg Glu Arg Arg Asn Asp Glu Leu Tyr Tyr Gln Ser Cys Glu Cys Val 
705                 710                 715                 720 


Ala Val Met Phe Ala Ser Ile Ala Asn Phe Ser Glu Phe Tyr Val Glu 
                725                 730                 735     


Leu Glu Ala Asn Asn Glu Gly Val Glu Cys Leu Arg Leu Leu Asn Glu 
            740                 745                 750         


Ile Ile Ala Asp Phe Asp Glu Ile Ile Ser Glu Asp Arg Phe Arg Gln 
        755                 760                 765             


Leu Glu Lys Ile Lys Xaa Ile Gly Ser Xaa Tyr Met Ala Ala Ser Gly 
    770                 775                 780                 


Leu Asn Asp Ser Xaa Tyr Asp Lys Val Gly Lys Xaa His Ile Lys Ala 
785                 790                 795                 800 


Leu Ala Asp Phe Ala Met Lys Leu Met Asp Gln Met Lys Tyr Ile Asn 
                805                 810                 815     


Glu His Ser Phe Asn Asn Phe Gln Met Lys Ile Gly Leu Asn Ile Gly 
            820                 825                 830         


Pro Val Val Ala Gly Val Ile Gly Ala Arg Lys Pro Gln Tyr Asp Ile 
        835                 840                 845             


Trp Gly Asn Xaa Val Asn Val Ala Ser Arg Met Asp Ser Xaa Gly Val 
    850                 855                 860                 


Pro Asp Arg Ile Gln Val Xaa Xaa Asp Met Tyr Gln Val Leu Ala Ala 
865                 870                 875                 880 


Asn Xaa Tyr Gln Leu Glu Cys Arg Gly Val Val Lys Val Lys Gly Lys 
                885                 890                 895     


Gly Glu Met Met Xaa Tyr Phe Leu Asn Gly Gly Pro Pro Leu Ser 
            900                 905                 910     


<210> 1578
<211> 1261
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1128)..(1128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1221)..(1222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<400> 1578
Met Ser Gly Ser Lys Ser Val Ser Pro Pro Gly Tyr Ala Ala Gln Lys 
1               5                   10                  15      


Xaa Ala Ala Pro Ala Pro Arg Gly Gly Pro Glu His Arg Ser Ala Trp 
            20                  25                  30          


Gly Glu Ala Asp Ser Arg Ala Asn Gly Tyr Pro His Ala Pro Gly Gly 
        35                  40                  45              


Ser Ala Arg Gly Ser Xaa Lys Lys Pro Gly Gly Ala Val Xaa Pro Gln 
    50                  55                  60                  


Gln Gln Gln Arg Leu Ala Ser Arg Trp Arg Ser Asp Asp Asp Asp Asp 
65                  70                  75                  80  


Pro Pro Leu Ser Gly Asp Asp Pro Leu Ala Gly Gly Phe Gly Phe Ser 
                85                  90                  95      


Phe Arg Ser Lys Ser Ala Trp Gln Glu Arg Gly Gly Asp Asp Cys Gly 
            100                 105                 110         


Arg Gly Ser Arg Arg Gln Arg Arg Gly Ala Ala Ser Gly Gly Ser Xaa 
        115                 120                 125             


Arg Ala Pro Pro Ala Gly Gly Gly Gly Gly Ser Ala Ala Ala Ala Ala 
    130                 135                 140                 


Ser Ala Gly Gly Xaa Glu Val Arg Pro Arg Ser Val Glu Val Gly Leu 
145                 150                 155                 160 


Glu Glu Arg Arg Gly Lys Gly Arg Ala Ala Asp Glu Leu Glu Ala Gly 
                165                 170                 175     


Ala Val Glu Gly Gly Glu Gly Ser Gly Asp Gly Gly Ser Ser Ala Asp 
            180                 185                 190         


Ser Gly Ser Gly Ala Gly Pro Gly Ala Val Leu Ser Leu Gly Ala Cys 
        195                 200                 205             


Cys Leu Ala Leu Leu Gln Ile Phe Arg Ser Lys Lys Phe Pro Ser Asp 
    210                 215                 220                 


Lys Leu Glu Arg Leu Tyr Gln Arg Tyr Phe Phe Arg Leu Asn Gln Ser 
225                 230                 235                 240 


Ser Leu Xaa Met Leu Met Ala Val Leu Val Leu Val Cys Leu Val Met 
                245                 250                 255     


Leu Ala Phe His Ala Ala Arg Pro Pro Leu Gln Leu Pro Tyr Leu Ala 
            260                 265                 270         


Val Leu Ala Ala Ala Val Gly Val Ile Leu Ile Met Ala Val Leu Cys 
        275                 280                 285             


Asn Arg Ala Ala Phe His Gln Asp His Met Gly Leu Ala Cys Tyr Ala 
    290                 295                 300                 


Leu Ile Ala Val Val Leu Ala Val Gln Val Val Gly Leu Leu Leu Pro 
305                 310                 315                 320 


Gln Pro Arg Ser Ala Ser Glu Gly Ile Trp Trp Xaa Val Phe Phe Ile 
                325                 330                 335     


Tyr Xaa Ile Tyr Xaa Leu Leu Pro Val Arg Met Arg Ala Ala Val Leu 
            340                 345                 350         


Ser Gly Val Leu Leu Ser Ala Leu His Leu Ala Ile Ala Leu Arg Xaa 
        355                 360                 365             


Asn Ala Gln Asp Gln Phe Leu Leu Lys Gln Leu Val Ser Asn Val Leu 
    370                 375                 380                 


Ile Phe Ser Cys Xaa Asn Ile Val Gly Val Cys Xaa His Tyr Pro Ala 
385                 390                 395                 400 


Glu Val Ser Gln Arg Gln Ala Phe Gln Glu Xaa Arg Glu Cys Ile Gln 
                405                 410                 415     


Ala Arg Leu His Ser Gln Arg Glu Asn Gln Gln Gln Glu Arg Leu Leu 
            420                 425                 430         


Leu Ser Val Leu Pro Arg His Val Ala Met Glu Met Lys Ala Asp Ile 
        435                 440                 445             


Asn Ala Lys Gln Glu Asp Met Met Phe His Lys Ile Tyr Ile Gln Lys 
    450                 455                 460                 


His Asp Asn Val Ser Ile Leu Phe Ala Asp Ile Glu Gly Phe Xaa Ser 
465                 470                 475                 480 


Leu Ala Ser Gln Cys Xaa Ala Gln Glu Leu Val Met Xaa Leu Asn Glu 
                485                 490                 495     


Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala Glu Asn His Cys Leu Arg 
            500                 505                 510         


Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu Pro Glu 
        515                 520                 525             


Ala Arg Ala Asp His Ala His Cys Cys Val Glu Met Gly Met Asp Met 
    530                 535                 540                 


Ile Glu Ala Ile Ser Leu Val Arg Glu Val Xaa Gly Val Asn Val Asn 
545                 550                 555                 560 


Met Arg Val Gly Ile His Ser Gly Arg Val His Cys Gly Val Leu Gly 
                565                 570                 575     


Leu Arg Lys Trp Gln Phe Asp Val Trp Ser Asn Asp Val Xaa Leu Ala 
            580                 585                 590         


Asn His Met Glu Ala Gly Gly Lys Ala Gly Arg Ile His Ile Xaa Lys 
        595                 600                 605             


Ala Xaa Leu Asn Tyr Leu Asn Gly Asp Tyr Glu Val Glu Pro Gly Cys 
    610                 615                 620                 


Gly Gly Glu Arg Asn Ala Tyr Leu Lys Glu His Ser Ile Glu Xaa Phe 
625                 630                 635                 640 


Leu Ile Leu Arg Cys Xaa Gln Lys Arg Lys Glu Glu Lys Ala Met Ile 
                645                 650                 655     


Ala Lys Met Asn Arg Gln Arg Xaa Asn Ser Ile Gly His Asn Pro Pro 
            660                 665                 670         


His Trp Gly Ala Glu Arg Pro Phe Tyr Asn His Leu Gly Gly Asn Gln 
        675                 680                 685             


Val Ser Lys Glu Met Lys Arg Met Gly Phe Glu Asp Pro Lys Asp Lys 
    690                 695                 700                 


Asn Ala Gln Glu Ser Ala Asn Pro Glu Asp Glu Val Asp Glu Phe Leu 
705                 710                 715                 720 


Gly Arg Ala Ile Asp Ala Arg Ser Ile Asp Arg Leu Arg Ser Glu His 
                725                 730                 735     


Val Arg Lys Phe Leu Leu Xaa Phe Arg Glu Pro Asp Leu Glu Lys Lys 
            740                 745                 750         


Tyr Ser Lys Gln Val Asp Asp Arg Phe Gly Ala Tyr Val Ala Cys Ala 
        755                 760                 765             


Ser Leu Val Phe Leu Phe Ile Cys Phe Val Gln Ile Xaa Ile Val Pro 
    770                 775                 780                 


His Ser Ile Phe Met Leu Ser Phe Tyr Leu Xaa Cys Ser Leu Leu Leu 
785                 790                 795                 800 


Xaa Leu Val Val Phe Val Ser Val Ile Tyr Ser Cys Val Lys Leu Phe 
                805                 810                 815     


Pro Ser Pro Leu Gln Xaa Leu Ser Arg Lys Ile Val Arg Ser Lys Met 
            820                 825                 830         


Asn Ser Xaa Leu Val Gly Val Phe Xaa Ile Xaa Leu Val Phe Leu Ala 
        835                 840                 845             


Ala Phe Val Asn Met Phe Xaa Cys Asn Ser Arg Asp Leu Leu Gly Cys 
    850                 855                 860                 


Leu Ala Gln Glu His Asn Ile Ser Ala Ser Gln Val Asn Ala Cys His 
865                 870                 875                 880 


Val Ala Glu Ser Ala Val Asn Tyr Ser Leu Gly Asp Glu Gln Gly Phe 
                885                 890                 895     


Cys Gly Ser Pro Trp Pro Asn Cys Asn Phe Pro Glu Tyr Phe Xaa Tyr 
            900                 905                 910         


Ser Val Leu Leu Ser Leu Leu Ala Cys Ser Val Phe Leu Gln Ile Ser 
        915                 920                 925             


Cys Ile Gly Lys Leu Val Leu Met Leu Ala Ile Glu Leu Ile Tyr Val 
    930                 935                 940                 


Leu Ile Val Glu Val Pro Gly Val Xaa Leu Phe Asp Asn Ala Asp Leu 
945                 950                 955                 960 


Leu Val Xaa Ala Asn Ala Ile Asp Phe Phe Asn Asn Gly Xaa Ser Gln 
                965                 970                 975     


Cys Pro Glu His Ala Xaa Lys Val Ala Leu Lys Val Val Xaa Pro Ile 
            980                 985                 990         


Ile Ile Ser Val Phe Val Leu Ala  Leu Tyr Leu His Ala  Gln Gln Val 
        995                 1000                 1005             


Glu Ser  Xaa Ala Arg Leu Asp  Phe Leu Trp Lys Leu  Gln Ala Xaa 
    1010                 1015                 1020             


Glu Glu  Lys Glu Glu Met Glu  Glu Leu Gln Ala Tyr  Asn Arg Arg 
    1025                 1030                 1035             


Leu Leu  His Asn Ile Leu Pro  Lys Asp Val Ala Ala  His Phe Leu 
    1040                 1045                 1050             


Ala Arg  Glu Arg Arg Asn Asp  Glu Leu Tyr Tyr Gln  Ser Cys Glu 
    1055                 1060                 1065             


Cys Val  Ala Val Met Phe Ala  Ser Ile Ala Asn Phe  Ser Glu Phe 
    1070                 1075                 1080             


Tyr Val  Glu Leu Glu Ala Asn  Asn Glu Gly Val Glu  Cys Leu Arg 
    1085                 1090                 1095             


Leu Leu  Asn Glu Ile Ile Ala  Asp Phe Asp Glu Ile  Ile Ser Glu 
    1100                 1105                 1110             


Asp Arg  Phe Arg Gln Leu Glu  Lys Ile Lys Xaa Ile  Gly Ser Xaa 
    1115                 1120                 1125             


Tyr Met  Ala Ala Ser Gly Leu  Asn Asp Ser Xaa Tyr  Asp Lys Val 
    1130                 1135                 1140             


Gly Lys  Xaa His Ile Lys Ala  Leu Ala Asp Phe Ala  Met Lys Leu 
    1145                 1150                 1155             


Met Asp  Gln Met Lys Tyr Ile  Asn Glu His Ser Phe  Asn Asn Phe 
    1160                 1165                 1170             


Gln Met  Lys Ile Gly Leu Asn  Ile Gly Pro Val Val  Ala Gly Val 
    1175                 1180                 1185             


Ile Gly  Ala Arg Lys Pro Gln  Tyr Asp Ile Trp Gly  Asn Xaa Val 
    1190                 1195                 1200             


Asn Val  Ala Ser Arg Met Asp  Ser Xaa Gly Val Pro  Asp Arg Ile 
    1205                 1210                 1215             


Gln Val  Xaa Xaa Asp Met Tyr  Gln Val Leu Ala Ala  Asn Xaa Tyr 
    1220                 1225                 1230             


Gln Leu  Glu Cys Arg Gly Val  Val Lys Val Lys Gly  Lys Gly Glu 
    1235                 1240                 1245             


Met Met  Xaa Tyr Phe Leu Asn  Gly Gly Pro Pro Leu  Ser 
    1250                 1255                 1260     


<210> 1579
<211> 1115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (983)..(983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1105)..(1106)
<223> Selenocysteine

<400> 1579
Met Ser Trp Phe Ser Gly Leu Leu Val Pro Lys Val Asp Glu Arg Lys 
1               5                   10                  15      


Xaa Ala Trp Gly Glu Arg Asn Gly Gln Lys Arg Ser Arg Arg Arg Gly 
            20                  25                  30          


Xaa Arg Ala Gly Gly Phe Cys Xaa Pro Arg Tyr Met Ser Cys Leu Arg 
        35                  40                  45              


Asp Ala Glu Pro Pro Ser Pro Xaa Pro Ala Gly Pro Pro Arg Cys Pro 
    50                  55                  60                  


Trp Gln Asp Asp Ala Phe Ile Arg Arg Gly Gly Pro Gly Lys Gly Lys 
65                  70                  75                  80  


Glu Leu Gly Leu Arg Ala Val Ala Leu Gly Phe Glu Asp Xaa Glu Val 
                85                  90                  95      


Xaa Xaa Xaa Ala Gly Gly Xaa Ala Glu Val Ala Pro Asp Ala Val Pro 
            100                 105                 110         


Arg Ser Gly Arg Ser Cys Trp Arg Arg Leu Val Gln Val Phe Gln Ser 
        115                 120                 125             


Lys Gln Phe Arg Ser Ala Lys Leu Glu Arg Leu Tyr Gln Arg Tyr Phe 
    130                 135                 140                 


Phe Gln Met Asn Gln Ser Ser Leu Xaa Leu Leu Met Ala Val Leu Val 
145                 150                 155                 160 


Leu Leu Xaa Ala Val Leu Leu Ala Phe His Ala Ala Pro Ala Arg Pro 
                165                 170                 175     


Gln Pro Ala Tyr Val Ala Leu Leu Ala Cys Ala Ala Ala Leu Phe Val 
            180                 185                 190         


Gly Leu Met Val Val Cys Asn Arg His Ser Phe Arg Gln Asp Ser Met 
        195                 200                 205             


Trp Val Val Ser Tyr Val Val Leu Gly Ile Leu Ala Ala Val Gln Val 
    210                 215                 220                 


Gly Gly Ala Leu Ala Ala Asp Pro Arg Ser Pro Ser Ala Gly Leu Trp 
225                 230                 235                 240 


Cys Pro Val Phe Phe Val Tyr Ile Ala Tyr Xaa Leu Leu Pro Ile Arg 
                245                 250                 255     


Met Arg Ala Ala Val Leu Ser Gly Leu Gly Leu Ser Xaa Leu His Leu 
            260                 265                 270         


Ile Leu Ala Trp Gln Leu Asn Arg Gly Asp Ala Phe Leu Trp Lys Gln 
        275                 280                 285             


Leu Gly Ala Asn Val Leu Leu Phe Leu Cys Xaa Asn Val Ile Gly Ile 
    290                 295                 300                 


Cys Xaa His Tyr Pro Ala Glu Val Ser Gln Arg Gln Ala Phe Gln Glu 
305                 310                 315                 320 


Xaa Arg Gly Tyr Ile Gln Ala Arg Leu His Leu Gln His Glu Asn Arg 
                325                 330                 335     


Gln Gln Glu Arg Leu Leu Leu Ser Val Leu Pro Gln His Val Ala Met 
            340                 345                 350         


Glu Met Lys Glu Asp Ile Asn Xaa Lys Lys Glu Asp Met Met Phe His 
        355                 360                 365             


Lys Ile Tyr Ile Gln Lys His Asp Asn Val Ser Ile Leu Phe Ala Asp 
    370                 375                 380                 


Ile Glu Gly Phe Xaa Ser Leu Ala Ser Gln Cys Xaa Ala Gln Glu Leu 
385                 390                 395                 400 


Val Met Xaa Leu Asn Glu Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala 
                405                 410                 415     


Glu Asn His Cys Leu Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys 
            420                 425                 430         


Val Ser Gly Leu Pro Glu Ala Arg Ala Asp His Ala His Cys Cys Val 
        435                 440                 445             


Glu Met Gly Val Asp Met Ile Glu Ala Ile Ser Leu Val Arg Glu Val 
    450                 455                 460                 


Xaa Gly Val Asn Val Asn Met Arg Val Gly Ile His Ser Gly Arg Val 
465                 470                 475                 480 


His Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Phe Asp Val Trp Ser 
                485                 490                 495     


Asn Asp Val Xaa Leu Ala Asn His Met Glu Ala Gly Gly Arg Ala Gly 
            500                 505                 510         


Arg Ile His Ile Xaa Arg Ala Xaa Leu Gln Tyr Leu Asn Gly Asp Tyr 
        515                 520                 525             


Glu Val Glu Pro Gly Arg Gly Gly Glu Arg Asn Ala Tyr Leu Lys Glu 
    530                 535                 540                 


Gln His Ile Glu Xaa Phe Leu Ile Leu Gly Ala Ser Gln Lys Arg Lys 
545                 550                 555                 560 


Glu Glu Lys Ala Met Leu Ala Lys Leu Gln Arg Xaa Arg Ala Asn Ser 
                565                 570                 575     


Met Glu Gly Leu Met Pro Arg Trp Val Pro Asp Arg Ala Phe Ser Arg 
            580                 585                 590         


Xaa Lys Asp Ser Lys Ala Phe Arg Gln Met Gly Ile Asp Asp Ser Ser 
        595                 600                 605             


Lys Asp Asn Arg Gly Xaa Gln Asp Ala Leu Asn Pro Glu Asp Glu Val 
    610                 615                 620                 


Asp Glu Phe Leu Ser Arg Ala Ile Asp Ala Arg Ser Ile Asp Gln Leu 
625                 630                 635                 640 


Arg Lys Asp His Val Arg Arg Phe Leu Leu Xaa Phe Gln Arg Glu Asp 
                645                 650                 655     


Leu Glu Lys Lys Tyr Ser Arg Lys Val Asp Pro Arg Phe Gly Ala Tyr 
            660                 665                 670         


Val Ala Cys Ala Leu Leu Val Phe Cys Phe Ile Cys Phe Ile Gln Leu 
        675                 680                 685             


Leu Ile Phe Pro His Ser Xaa Leu Met Leu Gly Ile Tyr Ala Ser Ile 
    690                 695                 700                 


Phe Leu Leu Leu Leu Ile Xaa Val Leu Ile Cys Ala Val Tyr Ser Cys 
705                 710                 715                 720 


Gly Ser Leu Phe Pro Lys Ala Leu Gln Arg Leu Ser Arg Ser Ile Val 
                725                 730                 735     


Arg Ser Arg Ala His Ser Xaa Ala Val Gly Ile Phe Ser Val Leu Leu 
            740                 745                 750         


Val Phe Xaa Ser Ala Ile Ala Asn Met Tyr Phe Ile Gly Asn Met Leu 
        755                 760                 765             


Leu Ser Leu Leu Ala Ser Ser Val Phe Leu His Ile Ser Ser Ile Gly 
    770                 775                 780                 


Lys Leu Ala Met Ile Phe Val Leu Gly Leu Ile Tyr Leu Val Leu Leu 
785                 790                 795                 800 


Leu Leu Gly Pro Pro Ala Xaa Ile Phe Asp Asn Tyr Asp Leu Leu Leu 
                805                 810                 815     


Gly Val His Gly Leu Ala Ser Ser Asn Glu Xaa Phe Asp Gly Leu Asp 
            820                 825                 830         


Cys Pro Ala Ala Gly Arg Val Ala Leu Lys Tyr Met Xaa Pro Val Ile 
        835                 840                 845             


Leu Leu Val Phe Ala Leu Ala Leu Tyr Leu His Ala Gln Gln Val Glu 
    850                 855                 860                 


Ser Xaa Ala Arg Leu Asp Phe Leu Trp Lys Leu Gln Ala Xaa Gly Glu 
865                 870                 875                 880 


Lys Glu Glu Met Glu Glu Leu Gln Ala Tyr Asn Arg Arg Leu Leu His 
                885                 890                 895     


Asn Ile Leu Pro Lys Asp Val Ala Ala His Phe Leu Ala Arg Glu Arg 
            900                 905                 910         


Arg Asn Asp Glu Leu Tyr Tyr Gln Ser Cys Glu Cys Val Ala Val Met 
        915                 920                 925             


Phe Ala Ser Ile Ala Asn Phe Ser Glu Phe Tyr Val Glu Leu Glu Ala 
    930                 935                 940                 


Asn Asn Glu Gly Val Glu Cys Leu Arg Leu Leu Asn Glu Ile Ile Ala 
945                 950                 955                 960 


Asp Phe Asp Glu Ile Ile Ser Glu Glu Arg Phe Arg Gln Leu Glu Lys 
                965                 970                 975     


Ile Lys Xaa Ile Gly Ser Xaa Tyr Met Ala Ala Ser Gly Leu Asn Ala 
            980                 985                 990         


Ser Xaa Tyr Asp Gln Val Gly Arg  Ser His Ile Xaa Ala  Leu Ala Asp 
        995                 1000                 1005             


Tyr Ala  Met Arg Leu Met Glu  Gln Met Lys His Ile  Asn Glu His 
    1010                 1015                 1020             


Ser Phe  Asn Asn Phe Gln Met  Lys Ile Gly Leu Asn  Met Gly Pro 
    1025                 1030                 1035             


Val Val  Ala Gly Val Ile Gly  Ala Arg Lys Pro Gln  Tyr Asp Ile 
    1040                 1045                 1050             


Trp Gly  Asn Xaa Val Asn Val  Ser Ser Arg Met Asp  Ser Xaa Gly 
    1055                 1060                 1065             


Val Pro  Asp Arg Ile Gln Val  Xaa Xaa Asp Leu Tyr  Gln Val Leu 
    1070                 1075                 1080             


Ala Ala  Lys Gly Tyr Gln Leu  Glu Cys Arg Gly Val  Val Lys Val 
    1085                 1090                 1095             


Lys Gly  Lys Gly Glu Met Xaa  Xaa Tyr Phe Leu Asn  Gly Gly Pro 
    1100                 1105                 1110             


Ser Ser  
    1115 


<210> 1580
<211> 1168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1120)..(1120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1159)
<223> Selenocysteine

<400> 1580
Met Ser Trp Phe Ser Gly Leu Leu Val Pro Lys Val Asp Glu Arg Lys 
1               5                   10                  15      


Xaa Ala Trp Gly Glu Arg Asn Gly Gln Lys Arg Ser Arg Arg Arg Gly 
            20                  25                  30          


Xaa Arg Ala Gly Gly Phe Cys Xaa Pro Arg Tyr Met Ser Cys Leu Arg 
        35                  40                  45              


Asp Ala Glu Pro Pro Ser Pro Xaa Pro Ala Gly Pro Pro Arg Cys Pro 
    50                  55                  60                  


Trp Gln Asp Asp Ala Phe Ile Arg Arg Gly Gly Pro Gly Lys Gly Lys 
65                  70                  75                  80  


Glu Leu Gly Leu Arg Ala Val Ala Leu Gly Phe Glu Asp Xaa Glu Val 
                85                  90                  95      


Xaa Xaa Xaa Ala Gly Gly Xaa Ala Glu Val Ala Pro Asp Ala Val Pro 
            100                 105                 110         


Arg Ser Gly Arg Ser Cys Trp Arg Arg Leu Val Gln Val Phe Gln Ser 
        115                 120                 125             


Lys Gln Phe Arg Ser Ala Lys Leu Glu Arg Leu Tyr Gln Arg Tyr Phe 
    130                 135                 140                 


Phe Gln Met Asn Gln Ser Ser Leu Xaa Leu Leu Met Ala Val Leu Val 
145                 150                 155                 160 


Leu Leu Xaa Ala Val Leu Leu Ala Phe His Ala Ala Pro Ala Arg Pro 
                165                 170                 175     


Gln Pro Ala Tyr Val Ala Leu Leu Ala Cys Ala Ala Ala Leu Phe Val 
            180                 185                 190         


Gly Leu Met Val Val Cys Asn Arg His Ser Phe Arg Gln Asp Ser Met 
        195                 200                 205             


Trp Val Val Ser Tyr Val Val Leu Gly Ile Leu Ala Ala Val Gln Val 
    210                 215                 220                 


Gly Gly Ala Leu Ala Ala Asp Pro Arg Ser Pro Ser Ala Gly Leu Trp 
225                 230                 235                 240 


Cys Pro Val Phe Phe Val Tyr Ile Ala Tyr Xaa Leu Leu Pro Ile Arg 
                245                 250                 255     


Met Arg Ala Ala Val Leu Ser Gly Leu Gly Leu Ser Xaa Leu His Leu 
            260                 265                 270         


Ile Leu Ala Trp Gln Leu Asn Arg Gly Asp Ala Phe Leu Trp Lys Gln 
        275                 280                 285             


Leu Gly Ala Asn Val Leu Leu Phe Leu Cys Xaa Asn Val Ile Gly Ile 
    290                 295                 300                 


Cys Xaa His Tyr Pro Ala Glu Val Ser Gln Arg Gln Ala Phe Gln Glu 
305                 310                 315                 320 


Xaa Arg Gly Tyr Ile Gln Ala Arg Leu His Leu Gln His Glu Asn Arg 
                325                 330                 335     


Gln Gln Glu Arg Leu Leu Leu Ser Val Leu Pro Gln His Val Ala Met 
            340                 345                 350         


Glu Met Lys Glu Asp Ile Asn Xaa Lys Lys Glu Asp Met Met Phe His 
        355                 360                 365             


Lys Ile Tyr Ile Gln Lys His Asp Asn Val Ser Ile Leu Phe Ala Asp 
    370                 375                 380                 


Ile Glu Gly Phe Xaa Ser Leu Ala Ser Gln Cys Xaa Ala Gln Glu Leu 
385                 390                 395                 400 


Val Met Xaa Leu Asn Glu Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala 
                405                 410                 415     


Glu Asn His Cys Leu Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys 
            420                 425                 430         


Val Ser Gly Leu Pro Glu Ala Arg Ala Asp His Ala His Cys Cys Val 
        435                 440                 445             


Glu Met Gly Val Asp Met Ile Glu Ala Ile Ser Leu Val Arg Glu Val 
    450                 455                 460                 


Xaa Gly Val Asn Val Asn Met Arg Val Gly Ile His Ser Gly Arg Val 
465                 470                 475                 480 


His Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Phe Asp Val Trp Ser 
                485                 490                 495     


Asn Asp Val Xaa Leu Ala Asn His Met Glu Ala Gly Gly Arg Ala Gly 
            500                 505                 510         


Arg Ile His Ile Xaa Arg Ala Xaa Leu Gln Tyr Leu Asn Gly Asp Tyr 
        515                 520                 525             


Glu Val Glu Pro Gly Arg Gly Gly Glu Arg Asn Ala Tyr Leu Lys Glu 
    530                 535                 540                 


Gln His Ile Glu Xaa Phe Leu Ile Leu Gly Ala Ser Gln Lys Arg Lys 
545                 550                 555                 560 


Glu Glu Lys Ala Met Leu Ala Lys Leu Gln Arg Xaa Arg Ala Asn Ser 
                565                 570                 575     


Met Glu Gly Leu Met Pro Arg Trp Val Pro Asp Arg Ala Phe Ser Arg 
            580                 585                 590         


Xaa Lys Asp Ser Lys Ala Phe Arg Gln Met Gly Ile Asp Asp Ser Ser 
        595                 600                 605             


Lys Asp Asn Arg Gly Xaa Gln Asp Ala Leu Asn Pro Glu Asp Glu Val 
    610                 615                 620                 


Asp Glu Phe Leu Ser Arg Ala Ile Asp Ala Arg Ser Ile Asp Gln Leu 
625                 630                 635                 640 


Arg Lys Asp His Val Arg Arg Phe Leu Leu Xaa Phe Gln Arg Glu Asp 
                645                 650                 655     


Leu Glu Lys Lys Tyr Ser Arg Lys Val Asp Pro Arg Phe Gly Ala Tyr 
            660                 665                 670         


Val Ala Cys Ala Leu Leu Val Phe Cys Phe Ile Cys Phe Ile Gln Leu 
        675                 680                 685             


Leu Ile Phe Pro His Ser Xaa Leu Met Leu Gly Ile Tyr Ala Ser Ile 
    690                 695                 700                 


Phe Leu Leu Leu Leu Ile Xaa Val Leu Ile Cys Ala Val Tyr Ser Cys 
705                 710                 715                 720 


Gly Ser Leu Phe Pro Lys Ala Leu Gln Arg Leu Ser Arg Ser Ile Val 
                725                 730                 735     


Arg Ser Arg Ala His Ser Xaa Ala Val Gly Ile Phe Ser Val Leu Leu 
            740                 745                 750         


Val Phe Xaa Ser Ala Ile Ala Asn Met Phe Xaa Cys Asn His Xaa Pro 
        755                 760                 765             


Ile Arg Ser Cys Ala Ala Arg Met Leu Asn Leu Xaa Pro Ala Asp Ile 
    770                 775                 780                 


Xaa Ala Cys His Leu Gln Gln Leu Asn Tyr Ser Leu Gly Leu Asp Ala 
785                 790                 795                 800 


Pro Leu Cys Glu Gly Xaa Met Pro Xaa Cys Ser Phe Pro Glu Tyr Phe 
                805                 810                 815     


Ile Gly Asn Met Leu Leu Ser Leu Leu Ala Ser Ser Val Phe Leu His 
            820                 825                 830         


Ile Ser Ser Ile Gly Lys Leu Ala Met Ile Phe Val Leu Gly Leu Ile 
        835                 840                 845             


Tyr Leu Val Leu Leu Leu Leu Gly Pro Pro Ala Xaa Ile Phe Asp Asn 
    850                 855                 860                 


Tyr Asp Leu Leu Leu Gly Val His Gly Leu Ala Ser Ser Asn Glu Xaa 
865                 870                 875                 880 


Phe Asp Gly Leu Asp Cys Pro Ala Ala Gly Arg Val Ala Leu Lys Tyr 
                885                 890                 895     


Met Xaa Pro Val Ile Leu Leu Val Phe Ala Leu Ala Leu Tyr Leu His 
            900                 905                 910         


Ala Gln Gln Val Glu Ser Xaa Ala Arg Leu Asp Phe Leu Trp Lys Leu 
        915                 920                 925             


Gln Ala Xaa Gly Glu Lys Glu Glu Met Glu Glu Leu Gln Ala Tyr Asn 
    930                 935                 940                 


Arg Arg Leu Leu His Asn Ile Leu Pro Lys Asp Val Ala Ala His Phe 
945                 950                 955                 960 


Leu Ala Arg Glu Arg Arg Asn Asp Glu Leu Tyr Tyr Gln Ser Cys Glu 
                965                 970                 975     


Cys Val Ala Val Met Phe Ala Ser Ile Ala Asn Phe Ser Glu Phe Tyr 
            980                 985                 990         


Val Glu Leu Glu Ala Asn Asn Glu  Gly Val Glu Cys Leu  Arg Leu Leu 
        995                 1000                 1005             


Asn Glu  Ile Ile Ala Asp Phe  Asp Glu Ile Ile Ser  Glu Glu Arg 
    1010                 1015                 1020             


Phe Arg  Gln Leu Glu Lys Ile  Lys Xaa Ile Gly Ser  Xaa Tyr Met 
    1025                 1030                 1035             


Ala Ala  Ser Gly Leu Asn Ala  Ser Xaa Tyr Asp Gln  Val Gly Arg 
    1040                 1045                 1050             


Ser His  Ile Xaa Ala Leu Ala  Asp Tyr Ala Met Arg  Leu Met Glu 
    1055                 1060                 1065             


Gln Met  Lys His Ile Asn Glu  His Ser Phe Asn Asn  Phe Gln Met 
    1070                 1075                 1080             


Lys Ile  Gly Leu Asn Met Gly  Pro Val Val Ala Gly  Val Ile Gly 
    1085                 1090                 1095             


Ala Arg  Lys Pro Gln Tyr Asp  Ile Trp Gly Asn Xaa  Val Asn Val 
    1100                 1105                 1110             


Ser Ser  Arg Met Asp Ser Xaa  Gly Val Pro Asp Arg  Ile Gln Val 
    1115                 1120                 1125             


Xaa Xaa  Asp Leu Tyr Gln Val  Leu Ala Ala Lys Gly  Tyr Gln Leu 
    1130                 1135                 1140             


Glu Cys  Arg Gly Val Val Lys  Val Lys Gly Lys Gly  Glu Met Xaa 
    1145                 1150                 1155             


Xaa Tyr  Phe Leu Asn Gly Gly  Pro Ser Ser 
    1160                 1165             


<210> 1581
<211> 83
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<400> 1581
Met Val Xaa Val Cys Leu Cys His Leu Leu Gln Leu Gly Ala Asn Val 
1               5                   10                  15      


Leu Leu Phe Leu Cys Xaa Asn Val Ile Gly Ile Cys Xaa His Tyr Pro 
            20                  25                  30          


Ala Glu Val Ser Gln Arg Gln Ala Phe Gln Glu Xaa Arg Gly Tyr Ile 
        35                  40                  45              


Gln Ala Arg Leu His Leu Gln His Glu Asn Arg Gln Gln Glu Arg Leu 
    50                  55                  60                  


Leu Leu Ser Val Leu Pro Gln His Val Ala Met Glu Met Lys Glu Asp 
65                  70                  75                  80  


Ile Asn Xaa 
            


<210> 1582
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1582
Met Pro Ala Lys Gly Arg Tyr Phe Leu Asn Glu Gly Glu Glu Gly Pro 
1               5                   10                  15      


Asp 
    


<210> 1583
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<400> 1583
Met Pro Ala Lys Gly Arg Tyr Phe Leu Asn Glu Gly Glu Glu Gly Pro 
1               5                   10                  15      


Asp Gln Asp Ala Leu Tyr Glu Lys Tyr Gln Leu Xaa Ser Gln His Gly 
            20                  25                  30          


Pro Leu Leu Leu Xaa Leu Leu Leu Val Ala Ala Xaa Ala Cys Val Ala 
        35                  40                  45              


Leu Ile Ile Ile Ala Phe Ser Gln Gly Asp Pro Ser Arg His Gln Ala 
    50                  55                  60                  


Ile Leu Gly Met Ala Phe Leu Val Leu Ala Val Phe Ala Ala Leu Ser 
65                  70                  75                  80  


Val 
    


<210> 1584
<211> 433
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<400> 1584
Met Pro Ala Lys Gly Arg Tyr Phe Leu Asn Glu Gly Glu Glu Gly Pro 
1               5                   10                  15      


Asp Gln Asp Ala Leu Tyr Glu Lys Tyr Gln Leu Xaa Ser Gln His Gly 
            20                  25                  30          


Pro Leu Leu Leu Xaa Leu Leu Leu Val Ala Ala Xaa Ala Cys Val Ala 
        35                  40                  45              


Leu Ile Ile Ile Ala Phe Ser Gln Gly Asp Pro Ser Arg His Gln Ala 
    50                  55                  60                  


Ile Leu Gly Met Ala Phe Leu Val Leu Ala Val Phe Ala Ala Leu Ser 
65                  70                  75                  80  


Val Leu Met Tyr Val Glu Cys Leu Leu Arg Arg Trp Leu Arg Ala Leu 
                85                  90                  95      


Ala Leu Leu Xaa Trp Ala Cys Leu Val Ala Leu Gly Tyr Val Leu Val 
            100                 105                 110         


Phe Asp Ala Trp Xaa Lys Ala Ala Cys Ala Trp Glu Gln Val Pro Phe 
        115                 120                 125             


Phe Leu Phe Ile Val Phe Val Val Tyr Xaa Leu Leu Pro Phe Ser Met 
    130                 135                 140                 


Arg Gly Ala Val Ala Val Gly Ala Val Ser Xaa Ala Ser His Leu Leu 
145                 150                 155                 160 


Val Leu Gly Ser Leu Met Gly Gly Phe Xaa Xaa Pro Ser Val Arg Val 
                165                 170                 175     


Gly Leu Gln Leu Leu Ala Asn Ala Val Ile Phe Leu Cys Gly Asn Leu 
            180                 185                 190         


Xaa Gly Ala Phe His Lys His Gln Met Gln Asp Ala Ser Arg Asp Leu 
        195                 200                 205             


Phe Xaa Tyr Xaa Val Lys Cys Ile Gln Ile Arg Arg Lys Leu Arg Ile 
    210                 215                 220                 


Glu Lys Arg Gln Gln Glu Asn Leu Leu Leu Ser Val Leu Pro Ala His 
225                 230                 235                 240 


Ile Ser Met Gly Met Lys Leu Ala Ile Ile Glu Arg Leu Lys Glu His 
                245                 250                 255     


Gly Asp Arg Arg Cys Met Pro Asp Asn Asn Phe His Ser Leu Tyr Val 
            260                 265                 270         


Lys Arg His Gln Asn Val Ser Ile Leu Tyr Ala Asp Ile Val Gly Phe 
        275                 280                 285             


Xaa Gln Leu Ala Ser Asp Cys Ser Pro Lys Glu Leu Val Val Val Leu 
    290                 295                 300                 


Asn Glu Leu Phe Gly Lys Phe Asp Gln Ile Ala Lys Ala Asn Glu Cys 
305                 310                 315                 320 


Met Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu 
                325                 330                 335     


Pro Val Ser Leu Pro Xaa His Ala Arg Asn Cys Val Lys Met Gly Leu 
            340                 345                 350         


Asp Met Cys Gln Ala Ile Lys Gln Val Arg Glu Ala Xaa Gly Val Asp 
        355                 360                 365             


Ile Asn Met Arg Val Gly Ile His Ser Gly Asn Val Leu Cys Gly Val 
    370                 375                 380                 


Ile Gly Leu Arg Lys Trp Gln Tyr Asp Val Trp Ser His Asp Val Ser 
385                 390                 395                 400 


Leu Ala Asn Arg Met Glu Ala Ala Gly Val Pro Gly Arg Val His Ile 
                405                 410                 415     


Xaa Glu Ala Xaa Leu Lys His Leu Asp Lys Ala Leu Leu Leu Gln Val 
            420                 425                 430         


Arg 
    


<210> 1585
<211> 530
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<400> 1585
Met Pro Ala Lys Gly Arg Tyr Phe Leu Asn Glu Gly Glu Glu Gly Pro 
1               5                   10                  15      


Asp Gln Asp Ala Leu Tyr Glu Lys Tyr Gln Leu Xaa Ser Gln His Gly 
            20                  25                  30          


Pro Leu Leu Leu Xaa Leu Leu Leu Val Ala Ala Xaa Ala Cys Val Ala 
        35                  40                  45              


Leu Ile Ile Ile Ala Phe Ser Gln Gly Asp Pro Ser Arg His Gln Ala 
    50                  55                  60                  


Ile Leu Gly Met Ala Phe Leu Val Leu Ala Val Phe Ala Ala Leu Ser 
65                  70                  75                  80  


Val Leu Met Tyr Val Glu Cys Leu Leu Arg Arg Trp Leu Arg Ala Leu 
                85                  90                  95      


Ala Leu Leu Xaa Trp Ala Cys Leu Val Ala Leu Gly Tyr Val Leu Val 
            100                 105                 110         


Phe Asp Ala Trp Xaa Lys Ala Ala Cys Ala Trp Glu Gln Val Pro Phe 
        115                 120                 125             


Phe Leu Phe Ile Val Phe Val Val Tyr Xaa Leu Leu Pro Phe Ser Met 
    130                 135                 140                 


Arg Gly Ala Val Ala Val Gly Ala Val Ser Xaa Ala Ser His Leu Leu 
145                 150                 155                 160 


Val Leu Gly Ser Leu Met Gly Gly Phe Xaa Xaa Pro Ser Val Arg Val 
                165                 170                 175     


Gly Leu Gln Leu Leu Ala Asn Ala Val Ile Phe Leu Cys Gly Asn Leu 
            180                 185                 190         


Xaa Gly Ala Phe His Lys His Gln Met Gln Asp Ala Ser Arg Asp Leu 
        195                 200                 205             


Phe Xaa Tyr Xaa Val Lys Cys Ile Gln Ile Arg Arg Lys Leu Arg Ile 
    210                 215                 220                 


Glu Lys Arg Gln Gln Glu Asn Leu Leu Leu Ser Val Leu Pro Ala His 
225                 230                 235                 240 


Ile Ser Met Gly Met Lys Leu Ala Ile Ile Glu Arg Leu Lys Glu His 
                245                 250                 255     


Gly Asp Arg Arg Cys Met Pro Asp Asn Asn Phe His Ser Leu Tyr Val 
            260                 265                 270         


Lys Arg His Gln Asn Val Ser Ile Leu Tyr Ala Asp Ile Val Gly Phe 
        275                 280                 285             


Xaa Gln Leu Ala Ser Asp Cys Ser Pro Lys Glu Leu Val Val Val Leu 
    290                 295                 300                 


Asn Glu Leu Phe Gly Lys Phe Asp Gln Ile Ala Lys Ala Asn Glu Cys 
305                 310                 315                 320 


Met Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu 
                325                 330                 335     


Pro Val Ser Leu Pro Xaa His Ala Arg Asn Cys Val Lys Met Gly Leu 
            340                 345                 350         


Asp Met Cys Gln Ala Ile Lys Gln Val Arg Glu Ala Xaa Gly Val Asp 
        355                 360                 365             


Ile Asn Met Arg Val Gly Ile His Ser Gly Asn Val Leu Cys Gly Val 
    370                 375                 380                 


Ile Gly Leu Arg Lys Trp Gln Tyr Asp Val Trp Ser His Asp Val Ser 
385                 390                 395                 400 


Leu Ala Asn Arg Met Glu Ala Ala Gly Val Pro Gly Arg Val His Ile 
                405                 410                 415     


Xaa Glu Ala Xaa Leu Lys His Leu Asp Lys Ala Tyr Glu Val Glu Asp 
            420                 425                 430         


Gly His Gly Gln Gln Arg Asp Pro Tyr Leu Lys Glu Met Asn Ile Arg 
        435                 440                 445             


Xaa Tyr Leu Val Ile Asp Pro Arg Ser Gln Gln Pro Pro Pro Pro Ser 
    450                 455                 460                 


Gln His Leu Pro Arg Pro Lys Gly Asp Ala Ala Leu Lys Met Arg Ala 
465                 470                 475                 480 


Ser Val Arg Met Xaa Arg Tyr Leu Glu Ser Trp Gly Ala Ala Arg Pro 
                485                 490                 495     


Phe Ala His Leu Asn His Arg Glu Ser Val Ser Ser Glu Arg Ser Pro 
            500                 505                 510         


Ala Pro Pro Pro Asp Pro Arg Gln Lys His Val Pro Gln Gly Ala Val 
        515                 520                 525             


Gly Gly 
    530 


<210> 1586
<211> 734
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<400> 1586
Met Pro Ala Lys Gly Arg Tyr Phe Leu Asn Glu Gly Glu Glu Gly Pro 
1               5                   10                  15      


Asp Gln Asp Ala Leu Tyr Glu Lys Tyr Gln Leu Xaa Ser Gln His Gly 
            20                  25                  30          


Pro Leu Leu Leu Xaa Leu Leu Leu Val Ala Ala Xaa Ala Cys Val Ala 
        35                  40                  45              


Leu Ile Ile Ile Ala Phe Ser Gln Gly Asp Pro Ser Arg His Gln Ala 
    50                  55                  60                  


Ile Leu Gly Met Ala Phe Leu Val Leu Ala Val Phe Ala Ala Leu Ser 
65                  70                  75                  80  


Val Leu Met Tyr Val Glu Cys Leu Leu Arg Arg Trp Leu Arg Ala Leu 
                85                  90                  95      


Ala Leu Leu Xaa Trp Ala Cys Leu Val Ala Leu Gly Tyr Val Leu Val 
            100                 105                 110         


Phe Asp Ala Trp Xaa Lys Ala Ala Cys Ala Trp Glu Gln Val Pro Phe 
        115                 120                 125             


Phe Leu Phe Ile Val Phe Val Val Tyr Xaa Leu Leu Pro Phe Ser Met 
    130                 135                 140                 


Arg Gly Ala Val Ala Val Gly Ala Val Ser Xaa Ala Ser His Leu Leu 
145                 150                 155                 160 


Val Leu Gly Ser Leu Met Gly Gly Phe Xaa Xaa Pro Ser Val Arg Val 
                165                 170                 175     


Gly Leu Gln Leu Leu Ala Asn Ala Val Ile Phe Leu Cys Gly Asn Leu 
            180                 185                 190         


Xaa Gly Ala Phe His Lys His Gln Met Gln Asp Ala Ser Arg Asp Leu 
        195                 200                 205             


Phe Xaa Tyr Xaa Val Lys Cys Ile Gln Ile Arg Arg Lys Leu Arg Ile 
    210                 215                 220                 


Glu Lys Arg Gln Gln Glu Asn Leu Leu Leu Ser Val Leu Pro Ala His 
225                 230                 235                 240 


Ile Ser Met Gly Met Lys Leu Ala Ile Ile Glu Arg Leu Lys Glu His 
                245                 250                 255     


Gly Asp Arg Arg Cys Met Pro Asp Asn Asn Phe His Ser Leu Tyr Val 
            260                 265                 270         


Lys Arg His Gln Asn Val Ser Ile Leu Tyr Ala Asp Ile Val Gly Phe 
        275                 280                 285             


Xaa Gln Leu Ala Ser Asp Cys Ser Pro Lys Glu Leu Val Val Val Leu 
    290                 295                 300                 


Asn Glu Leu Phe Gly Lys Phe Asp Gln Ile Ala Lys Ala Asn Glu Cys 
305                 310                 315                 320 


Met Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu 
                325                 330                 335     


Pro Val Ser Leu Pro Xaa His Ala Arg Asn Cys Val Lys Met Gly Leu 
            340                 345                 350         


Asp Met Cys Gln Ala Ile Lys Gln Val Arg Glu Ala Xaa Gly Val Asp 
        355                 360                 365             


Ile Asn Met Arg Val Gly Ile His Ser Gly Asn Val Leu Cys Gly Val 
    370                 375                 380                 


Ile Gly Leu Arg Lys Trp Gln Tyr Asp Val Trp Ser His Asp Val Ser 
385                 390                 395                 400 


Leu Ala Asn Arg Met Glu Ala Ala Gly Val Pro Gly Arg Val His Ile 
                405                 410                 415     


Xaa Glu Ala Xaa Leu Lys His Leu Asp Lys Ala Tyr Glu Val Glu Asp 
            420                 425                 430         


Gly His Gly Gln Gln Arg Asp Pro Tyr Leu Lys Glu Met Asn Ile Arg 
        435                 440                 445             


Xaa Tyr Leu Val Ile Asp Pro Arg Ser Gln Gln Pro Pro Pro Pro Ser 
    450                 455                 460                 


Gln His Leu Pro Arg Pro Lys Gly Asp Ala Ala Leu Lys Met Arg Ala 
465                 470                 475                 480 


Ser Val Arg Met Xaa Arg Tyr Leu Glu Ser Trp Gly Ala Ala Arg Pro 
                485                 490                 495     


Phe Ala His Leu Asn His Arg Glu Ser Val Ser Ser Gly Glu Xaa His 
            500                 505                 510         


Val Pro Asn Gly Arg Arg Pro Lys Ser Val Pro Gln Arg His Arg Arg 
        515                 520                 525             


Xaa Pro Asp Arg Ser Met Ser Pro Lys Gly Arg Ser Glu Asp Asp Ser 
    530                 535                 540                 


Tyr Asp Asp Glu Met Leu Ser Ala Ile Glu Gly Leu Ser Ser Xaa Arg 
545                 550                 555                 560 


Pro Cys Cys Ser Lys Ser Asp Asp Phe Tyr Xaa Phe Gly Ser Ile Phe 
                565                 570                 575     


Leu Glu Lys Gly Phe Glu Arg Glu Tyr Arg Leu Ala Pro Ile Pro Arg 
            580                 585                 590         


Ala Arg His Asp Phe Ala Cys Ala Ser Leu Ile Phe Val Cys Ile Leu 
        595                 600                 605             


Leu Val His Val Leu Leu Met Pro Arg Xaa Ala Ala Leu Gly Val Ser 
    610                 615                 620                 


Phe Gly Leu Val Ala Cys Val Leu Gly Leu Val Leu Gly Leu Cys Phe 
625                 630                 635                 640 


Ala Xaa Lys Phe Ser Arg Cys Cys Pro Ala Arg Gly Xaa Leu Cys Xaa 
                645                 650                 655     


Ile Ser Glu Arg Val Glu Xaa Gln Pro Leu Leu Arg Leu Xaa Leu Ala 
            660                 665                 670         


Val Leu Xaa Ile Gly Ser Leu Leu Xaa Val Ala Ile Ile Asn Leu Pro 
        675                 680                 685             


Leu Met Pro Phe Gln Val Pro Glu Leu Pro Val Gly Asn Glu Xaa Gly 
    690                 695                 700                 


Leu Leu Ala Ala Ser Ser Lys Xaa Arg Ala Leu Cys Glu Pro Leu Pro 
705                 710                 715                 720 


His Leu His Xaa Val Phe Ser Arg Leu Asn Glu Leu Xaa Ser 
                725                 730                 


<210> 1587
<211> 1080
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1071)..(1071)
<223> Selenocysteine

<400> 1587
Met Pro Ala Lys Gly Arg Tyr Phe Leu Asn Glu Gly Glu Glu Gly Pro 
1               5                   10                  15      


Asp Gln Asp Ala Leu Tyr Glu Lys Tyr Gln Leu Xaa Ser Gln His Gly 
            20                  25                  30          


Pro Leu Leu Leu Xaa Leu Leu Leu Val Ala Ala Xaa Ala Cys Val Ala 
        35                  40                  45              


Leu Ile Ile Ile Ala Phe Ser Gln Gly Asp Pro Ser Arg His Gln Ala 
    50                  55                  60                  


Ile Leu Gly Met Ala Phe Leu Val Leu Ala Val Phe Ala Ala Leu Ser 
65                  70                  75                  80  


Val Leu Met Tyr Val Glu Cys Leu Leu Arg Arg Trp Leu Arg Ala Leu 
                85                  90                  95      


Ala Leu Leu Xaa Trp Ala Cys Leu Val Ala Leu Gly Tyr Val Leu Val 
            100                 105                 110         


Phe Asp Ala Trp Xaa Lys Ala Ala Cys Ala Trp Glu Gln Val Pro Phe 
        115                 120                 125             


Phe Leu Phe Ile Val Phe Val Val Tyr Xaa Leu Leu Pro Phe Ser Met 
    130                 135                 140                 


Arg Gly Ala Val Ala Val Gly Ala Val Ser Xaa Ala Ser His Leu Leu 
145                 150                 155                 160 


Val Leu Gly Ser Leu Met Gly Gly Phe Xaa Xaa Pro Ser Val Arg Val 
                165                 170                 175     


Gly Leu Gln Leu Leu Ala Asn Ala Val Ile Phe Leu Cys Gly Asn Leu 
            180                 185                 190         


Xaa Gly Ala Phe His Lys His Gln Met Gln Asp Ala Ser Arg Asp Leu 
        195                 200                 205             


Phe Xaa Tyr Xaa Val Lys Cys Ile Gln Ile Arg Arg Lys Leu Arg Ile 
    210                 215                 220                 


Glu Lys Arg Gln Gln Glu Asn Leu Leu Leu Ser Val Leu Pro Ala His 
225                 230                 235                 240 


Ile Ser Met Gly Met Lys Leu Ala Ile Ile Glu Arg Leu Lys Glu His 
                245                 250                 255     


Gly Asp Arg Arg Cys Met Pro Asp Asn Asn Phe His Ser Leu Tyr Val 
            260                 265                 270         


Lys Arg His Gln Asn Val Ser Ile Leu Tyr Ala Asp Ile Val Gly Phe 
        275                 280                 285             


Xaa Gln Leu Ala Ser Asp Cys Ser Pro Lys Glu Leu Val Val Val Leu 
    290                 295                 300                 


Asn Glu Leu Phe Gly Lys Phe Asp Gln Ile Ala Lys Ala Asn Glu Cys 
305                 310                 315                 320 


Met Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu 
                325                 330                 335     


Pro Val Ser Leu Pro Xaa His Ala Arg Asn Cys Val Lys Met Gly Leu 
            340                 345                 350         


Asp Met Cys Gln Ala Ile Lys Gln Val Arg Glu Ala Xaa Gly Val Asp 
        355                 360                 365             


Ile Asn Met Arg Val Gly Ile His Ser Gly Asn Val Leu Cys Gly Val 
    370                 375                 380                 


Ile Gly Leu Arg Lys Trp Gln Tyr Asp Val Trp Ser His Asp Val Ser 
385                 390                 395                 400 


Leu Ala Asn Arg Met Glu Ala Ala Gly Val Pro Gly Arg Val His Ile 
                405                 410                 415     


Xaa Glu Ala Xaa Leu Lys His Leu Asp Lys Ala Tyr Glu Val Glu Asp 
            420                 425                 430         


Gly His Gly Gln Gln Arg Asp Pro Tyr Leu Lys Glu Met Asn Ile Arg 
        435                 440                 445             


Xaa Tyr Leu Val Ile Asp Pro Arg Ser Gln Gln Pro Pro Pro Pro Ser 
    450                 455                 460                 


Gln His Leu Pro Arg Pro Lys Gly Asp Ala Ala Leu Lys Met Arg Ala 
465                 470                 475                 480 


Ser Val Arg Met Xaa Arg Tyr Leu Glu Ser Trp Gly Ala Ala Arg Pro 
                485                 490                 495     


Phe Ala His Leu Asn His Arg Glu Ser Val Ser Ser Gly Glu Xaa His 
            500                 505                 510         


Val Pro Asn Gly Arg Arg Pro Lys Ser Val Pro Gln Arg His Arg Arg 
        515                 520                 525             


Xaa Pro Asp Arg Ser Met Ser Pro Lys Gly Arg Ser Glu Asp Asp Ser 
    530                 535                 540                 


Tyr Asp Asp Glu Met Leu Ser Ala Ile Glu Gly Leu Ser Ser Xaa Arg 
545                 550                 555                 560 


Pro Cys Cys Ser Lys Ser Asp Asp Phe Tyr Xaa Phe Gly Ser Ile Phe 
                565                 570                 575     


Leu Glu Lys Gly Phe Glu Arg Glu Tyr Arg Leu Ala Pro Ile Pro Arg 
            580                 585                 590         


Ala Arg His Asp Phe Ala Cys Ala Ser Leu Ile Phe Val Cys Ile Leu 
        595                 600                 605             


Leu Val His Val Leu Leu Met Pro Arg Xaa Ala Ala Leu Gly Val Ser 
    610                 615                 620                 


Phe Gly Leu Val Ala Cys Val Leu Gly Leu Val Leu Gly Leu Cys Phe 
625                 630                 635                 640 


Ala Xaa Lys Phe Ser Arg Cys Cys Pro Ala Arg Gly Xaa Leu Cys Xaa 
                645                 650                 655     


Ile Ser Glu Arg Val Glu Xaa Gln Pro Leu Leu Arg Leu Xaa Leu Ala 
            660                 665                 670         


Val Leu Xaa Ile Gly Ser Leu Leu Xaa Val Ala Ile Ile Asn Leu Pro 
        675                 680                 685             


Leu Met Pro Phe Gln Val Pro Glu Leu Pro Val Gly Asn Glu Xaa Gly 
    690                 695                 700                 


Leu Leu Ala Ala Ser Ser Lys Xaa Arg Ala Leu Cys Glu Pro Leu Pro 
705                 710                 715                 720 


Tyr Tyr Xaa Cys Ser Cys Val Leu Gly Phe Ile Ala Cys Ser Val Phe 
                725                 730                 735     


Leu Arg Met Ser Leu Glu Pro Lys Val Val Leu Leu Xaa Val Ala Leu 
            740                 745                 750         


Val Ala Tyr Leu Val Leu Phe Asn Leu Ser Pro Cys Trp Gln Trp Asp 
        755                 760                 765             


Cys Cys Gly Gln Gly Leu Gly Asn Leu Xaa Lys Pro Asn Gly Xaa Xaa 
    770                 775                 780                 


Ser Gly Xaa Pro Ser Cys Ser Trp Lys Asp Leu Lys Xaa Met Xaa Asn 
785                 790                 795                 800 


Phe Tyr Leu Val Leu Phe Tyr Ile Xaa Leu Leu Xaa Leu Ser Arg Gln 
                805                 810                 815     


Ile Asp Tyr Tyr Cys Arg Leu Asp Cys Leu Trp Lys Lys Lys Phe Lys 
            820                 825                 830         


Lys Glu His Glu Glu Phe Glu Xaa Met Glu Asn Val Asn Arg Leu Leu 
        835                 840                 845             


Leu Glu Asn Val Leu Pro Ala His Val Ala Ala His Phe Ile Gly Asp 
    850                 855                 860                 


Lys Leu Asn Glu Asp Trp Tyr His Gln Ser Tyr Asp Cys Val Cys Val 
865                 870                 875                 880 


Met Phe Ala Ser Val Pro Asp Phe Lys Val Phe Tyr Xaa Glu Cys Asp 
                885                 890                 895     


Val Asn Lys Glu Gly Leu Glu Cys Leu Arg Leu Leu Asn Glu Ile Ile 
            900                 905                 910         


Ala Asp Phe Asp Glu Leu Leu Leu Lys Pro Lys Phe Ser Gly Val Glu 
        915                 920                 925             


Lys Ile Lys Xaa Ile Gly Ser Xaa Tyr Met Ala Ala Ala Gly Leu Ser 
    930                 935                 940                 


Val Ala Ser Gly His Glu Asn Gln Glu Leu Glu Arg Gln His Ala His 
945                 950                 955                 960 


Ile Gly Val Met Val Glu Phe Ser Ile Ala Leu Met Ser Lys Leu Asp 
                965                 970                 975     


Gly Ile Asn Arg His Ser Phe Asn Ser Phe Arg Leu Arg Val Gly Ile 
            980                 985                 990         


Asn His Gly Pro Val Ile Ala Gly  Val Ile Gly Ala Arg  Lys Pro Gln 
        995                 1000                 1005             


Tyr Asp  Ile Trp Gly Asn Xaa  Val Asn Val Ala Ser  Arg Met Glu 
    1010                 1015                 1020             


Ser Xaa  Gly Glu Leu Gly Lys  Ile Gln Val Xaa Glu  Glu Xaa Cys 
    1025                 1030                 1035             


Xaa Ile  Leu Gln Gly Leu Gly  Tyr Ser Cys Glu Cys  Arg Gly Leu 
    1040                 1045                 1050             


Ile Asn  Val Lys Gly Lys Gly  Glu Leu Arg Xaa Tyr  Phe Val Cys 
    1055                 1060                 1065             


Xaa Asp  Xaa Ala Lys Phe Gln  Gly Leu Gly Leu Asn  
    1070                 1075                 1080 


<210> 1588
<211> 109
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<400> 1588
Met Pro Ala Lys Gly Arg Tyr Phe Leu Asn Glu Gly Glu Glu Gly Pro 
1               5                   10                  15      


Asp Gln Asp Ala Leu Tyr Glu Lys Tyr Gln Leu Xaa Ser Gln His Gly 
            20                  25                  30          


Pro Leu Leu Leu Xaa Leu Leu Leu Val Ala Ala Xaa Ala Cys Val Ala 
        35                  40                  45              


Leu Ile Ile Ile Ala Phe Ser Gln Gly Arg His Gly Leu Ala Met Leu 
    50                  55                  60                  


Pro Arg Leu Val Leu Asn Ser Trp Pro Gln Val Ile Leu Leu Pro Trp 
65                  70                  75                  80  


Pro Pro Lys Val Leu Gly Leu Gln Asp Pro Ser Arg His Gln Ala Ile 
                85                  90                  95      


Leu Gly Met Ala Phe Leu Val Leu Ala Val Phe Ala Ala 
            100                 105                 


<210> 1589
<211> 1120
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (983)..(983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1105)..(1105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<400> 1589
Met Glu Leu Ser Asp Val Arg Cys Leu Xaa Gly Ser Glu Glu Leu Tyr 
1               5                   10                  15      


Xaa Ile His Pro Xaa Pro Pro Ala Gly Asp Gly Arg Ser Ala Ser Arg 
            20                  25                  30          


Pro Gln Arg Leu Leu Trp Gln Xaa Ala Val Arg His Ile Xaa Glu Gln 
        35                  40                  45              


Arg Phe Ile His Gly His Arg Gly Gly Ser Gly Ser Gly Ser Gly Gly 
    50                  55                  60                  


Ser Gly Lys Ala Ser Asp Pro Ala Gly Gly Gly Pro Asn His His Ala 
65                  70                  75                  80  


Pro Gln Leu Ser Gly Asp Ser Ala Leu Pro Leu Tyr Ser Leu Gly Pro 
                85                  90                  95      


Gly Glu Arg Ala His Ser Xaa Cys Gly Xaa Lys Val Phe Pro Glu Arg 
            100                 105                 110         


Ser Gly Ser Gly Ser Ala Ser Gly Ser Gly Gly Gly Gly Asp Leu Gly 
        115                 120                 125             


Phe Leu His Leu Asp Cys Ala Pro Ser Asn Ser Asp Phe Phe Leu Asn 
    130                 135                 140                 


Gly Gly Tyr Ser Tyr Arg Gly Val Ile Phe Pro Xaa Leu Arg Asn Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Asp Leu Glu Arg Leu Tyr Gln Arg Tyr Phe Leu Gly 
                165                 170                 175     


Gln Arg Arg Lys Ser Glu Val Val Met Asn Val Leu Asp Val Leu Xaa 
            180                 185                 190         


Lys Leu Xaa Leu Leu Val Leu His Leu Ser Leu Ala Ser Ala Pro Met 
        195                 200                 205             


Asp Pro Leu Lys Gly Ile Leu Leu Gly Phe Phe Xaa Gly Ile Glu Val 
    210                 215                 220                 


Val Ile Cys Ala Leu Val Val Val Arg Lys Asp Xaa Xaa Ser His Xaa 
225                 230                 235                 240 


Tyr Leu Gln Tyr Ser Gly Val Val Xaa Trp Val Ala Met Xaa Xaa Gln 
                245                 250                 255     


Ile Leu Ala Ala Gly Leu Gly Tyr Gly Leu Leu Gly Asp Gly Ile Gly 
            260                 265                 270         


Tyr Val Leu Phe Xaa Leu Phe Ala Xaa Tyr Ser Met Leu Pro Leu Pro 
        275                 280                 285             


Leu Xaa Trp Ala Ile Leu Ala Gly Leu Gly Xaa Ser Leu Leu Gln Val 
    290                 295                 300                 


Ile Leu Gln Val Val Ile Pro Arg Leu Ala Val Ile Ser Ile Asn Gln 
305                 310                 315                 320 


Val Val Ala Gln Ala Val Leu Phe Met Cys Met Asn Xaa Ala Gly Ile 
                325                 330                 335     


Phe Ile Ser Tyr Leu Ser Asp Arg Ala Gln Arg Gln Ala Phe Leu Glu 
            340                 345                 350         


Xaa Arg Arg Cys Val Glu Ala Arg Leu Arg Leu Glu Xaa Glu Asn Gln 
        355                 360                 365             


Arg Gln Glu Arg Leu Val Leu Ser Val Leu Pro Arg Phe Val Val Leu 
    370                 375                 380                 


Glu Met Ile Asn Asp Met Xaa Asn Val Glu Asp Glu His Leu Gln His 
385                 390                 395                 400 


Gln Phe His Arg Ile Tyr Ile His Arg Tyr Glu Asn Val Ser Ile Leu 
                405                 410                 415     


Phe Ala Asp Val Lys Gly Phe Xaa Asn Leu Ser Xaa Xaa Leu Ser Ala 
            420                 425                 430         


Gln Glu Leu Val Arg Met Leu Asn Glu Leu Phe Ala Arg Phe Asp Arg 
        435                 440                 445             


Leu Ala His Glu His His Cys Leu Arg Ile Lys Ile Leu Gly Asp Cys 
    450                 455                 460                 


Tyr Tyr Cys Val Ser Gly Leu Pro Glu Pro Arg Gln Asp His Ala His 
465                 470                 475                 480 


Cys Cys Val Glu Met Gly Leu Ser Met Ile Lys Xaa Ile Arg Tyr Val 
                485                 490                 495     


Arg Ser Arg Xaa Lys His Asp Val Asp Met Arg Ile Gly Ile His Ser 
            500                 505                 510         


Gly Ser Val Leu Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Phe Asp 
        515                 520                 525             


Val Trp Ser Trp Asp Val Asp Ile Ala Asn Lys Leu Glu Ser Gly Gly 
    530                 535                 540                 


Ile Pro Gly Arg Ile His Ile Ser Lys Ala Xaa Leu Asp Cys Leu Asn 
545                 550                 555                 560 


Gly Asp Tyr Asn Val Glu Glu Gly His Gly Lys Glu Arg Asn Glu Phe 
                565                 570                 575     


Leu Arg Lys His Asn Ile Glu Xaa Tyr Leu Ile Lys Gln Pro Glu Asp 
            580                 585                 590         


Ser Leu Leu Ser Leu Pro Glu Asp Ile Val Lys Glu Ser Val Ser Ser 
        595                 600                 605             


Ser Asp Arg Arg Asn Ser Gly Ala Xaa Phe Xaa Glu Gly Ser Trp Ser 
    610                 615                 620                 


Pro Glu Leu Pro Phe Asp Asn Ile Val Gly Lys Gln Asn Xaa Leu Ala 
625                 630                 635                 640 


Ala Leu Xaa Arg Asn Ser Ile Asn Leu Leu Pro Asn His Leu Ala Gln 
                645                 650                 655     


Ala Leu His Val Gln Ser Gly Pro Glu Glu Ile Asn Lys Arg Ile Glu 
            660                 665                 670         


His Xaa Ile Asp Leu Arg Ser Gly Asp Lys Leu Arg Arg Glu His Ile 
        675                 680                 685             


Lys Pro Phe Ser Leu Met Phe Lys Asp Ser Ser Leu Glu His Lys Tyr 
    690                 695                 700                 


Phe Val Phe Xaa Gly Val Leu Ala Met Val Xaa Cys Ala Val Phe Leu 
705                 710                 715                 720 


Arg Leu Asn Ser Val Leu Lys Leu Ala Val Leu Leu Ile Met Ile Ala 
                725                 730                 735     


Ile Tyr Ala Leu Leu Xaa Glu Xaa Val Tyr Ala Gly Leu Phe Leu Arg 
            740                 745                 750         


Tyr Asp Asn Leu Asn His Ser Gly Glu Asp Phe Leu Gly Xaa Lys Glu 
        755                 760                 765             


Val Ser Leu Leu Leu Met Ala Met Phe Leu Leu Ala Val Phe Tyr His 
    770                 775                 780                 


Gly Gln Gln Leu Glu Tyr Xaa Ala Arg Leu Asp Phe Leu Trp Arg Val 
785                 790                 795                 800 


Gln Ala Lys Glu Glu Ile Asn Glu Met Lys Glu Leu Arg Glu His Asn 
                805                 810                 815     


Glu Asn Met Leu Arg Asn Ile Leu Pro Ser His Val Ala Arg His Phe 
            820                 825                 830         


Leu Glu Lys Asp Arg Asp Asn Glu Glu Leu Tyr Ser Gln Ser Tyr Asp 
        835                 840                 845             


Ala Val Gly Val Met Phe Ala Ser Ile Pro Gly Phe Ala Asp Phe Tyr 
    850                 855                 860                 


Ser Gln Xaa Glu Met Asn Asn Gln Gly Val Glu Cys Leu Arg Leu Leu 
865                 870                 875                 880 


Asn Glu Ile Ile Ala Asp Phe Asp Glu Leu Leu Gly Glu Asp Arg Phe 
                885                 890                 895     


Gln Asp Ile Glu Lys Ile Lys Xaa Ile Gly Ser Xaa Tyr Met Ala Val 
            900                 905                 910         


Ser Gly Leu Ser Pro Glu Lys Gln Gln Cys Glu Asp Lys Trp Gly His 
        915                 920                 925             


Leu Cys Ala Leu Ala Asp Phe Ser Leu Ala Leu Xaa Glu Ser Ile Gln 
    930                 935                 940                 


Glu Ile Asn Lys His Ser Phe Asn Asn Phe Glu Leu Arg Ile Gly Ile 
945                 950                 955                 960 


Ser His Gly Ser Val Val Ala Gly Val Ile Gly Ala Lys Lys Pro Gln 
                965                 970                 975     


Tyr Asp Ile Trp Gly Lys Xaa Val Asn Leu Ala Ser Arg Met Asp Ser 
            980                 985                 990         


Xaa Gly Val Ser Gly Arg Ile Gln  Val Pro Glu Glu Xaa  Tyr Leu Ile 
        995                 1000                 1005             


Leu Lys  Asp Gln Gly Phe Ala  Phe Asp Tyr Arg Gly  Glu Ile Tyr 
    1010                 1015                 1020             


Val Lys  Gly Ile Ser Glu Gln  Glu Gly Lys Ile Lys  Xaa Tyr Phe 
    1025                 1030                 1035             


Leu Leu  Gly Arg Val Gln Pro  Asn Pro Phe Ile Leu  Pro Pro Arg 
    1040                 1045                 1050             


Arg Leu  Pro Gly Gln Tyr Ser  Leu Ala Ala Val Val  Leu Gly Leu 
    1055                 1060                 1065             


Val Gln  Ser Leu Asn Arg Gln  Arg Gln Lys Gln Leu  Leu Asn Glu 
    1070                 1075                 1080             


Asn Asn  Asn Xaa Gly Ile Ile  Lys Gly His Tyr Asn  Arg Arg Xaa 
    1085                 1090                 1095             


Leu Leu  Ser Pro Ser Gly Xaa  Glu Pro Gly Ala Gln  Ala Glu Gly 
    1100                 1105                 1110             


Xaa Asp  Lys Ser Asp Leu Pro  
    1115                 1120 


<210> 1590
<211> 1251
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (873)..(873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1071)..(1071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1218)..(1218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1245)..(1245)
<223> Selenocysteine

<400> 1590
Met Glu Leu Ser Asp Val Arg Cys Leu Xaa Gly Ser Glu Glu Leu Tyr 
1               5                   10                  15      


Xaa Ile His Pro Xaa Pro Pro Ala Gly Asp Gly Arg Ser Ala Ser Arg 
            20                  25                  30          


Pro Gln Arg Leu Leu Trp Gln Xaa Ala Val Arg His Ile Xaa Glu Gln 
        35                  40                  45              


Arg Phe Ile His Gly His Arg Gly Gly Ser Gly Ser Gly Ser Gly Gly 
    50                  55                  60                  


Ser Gly Lys Ala Ser Asp Pro Ala Gly Gly Gly Pro Asn His His Ala 
65                  70                  75                  80  


Pro Gln Leu Ser Gly Asp Ser Ala Leu Pro Leu Tyr Ser Leu Gly Pro 
                85                  90                  95      


Gly Glu Arg Ala His Ser Xaa Cys Gly Xaa Lys Val Phe Pro Glu Arg 
            100                 105                 110         


Ser Gly Ser Gly Ser Ala Ser Gly Ser Gly Gly Gly Gly Asp Leu Gly 
        115                 120                 125             


Phe Leu His Leu Asp Cys Ala Pro Ser Asn Ser Asp Phe Phe Leu Asn 
    130                 135                 140                 


Gly Gly Tyr Ser Tyr Arg Gly Val Ile Phe Pro Xaa Leu Arg Asn Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Asp Leu Glu Arg Leu Tyr Gln Arg Tyr Phe Leu Gly 
                165                 170                 175     


Gln Arg Arg Lys Ser Glu Val Val Met Asn Val Leu Asp Val Leu Xaa 
            180                 185                 190         


Lys Leu Xaa Leu Leu Val Leu His Leu Ser Leu Ala Ser Ala Pro Met 
        195                 200                 205             


Asp Pro Leu Lys Gly Ile Leu Leu Gly Phe Phe Xaa Gly Ile Glu Val 
    210                 215                 220                 


Val Ile Cys Ala Leu Val Val Val Arg Lys Asp Xaa Xaa Ser His Xaa 
225                 230                 235                 240 


Tyr Leu Gln Tyr Ser Gly Val Val Xaa Trp Val Ala Met Xaa Xaa Gln 
                245                 250                 255     


Ile Leu Ala Ala Gly Leu Gly Tyr Gly Leu Leu Gly Asp Gly Ile Gly 
            260                 265                 270         


Tyr Val Leu Phe Xaa Leu Phe Ala Xaa Tyr Ser Met Leu Pro Leu Pro 
        275                 280                 285             


Leu Xaa Trp Ala Ile Leu Ala Gly Leu Gly Xaa Ser Leu Leu Gln Val 
    290                 295                 300                 


Ile Leu Gln Val Val Ile Pro Arg Leu Ala Val Ile Ser Ile Asn Gln 
305                 310                 315                 320 


Val Val Ala Gln Ala Val Leu Phe Met Cys Met Asn Xaa Ala Gly Ile 
                325                 330                 335     


Phe Ile Ser Tyr Leu Ser Asp Arg Ala Gln Arg Gln Ala Phe Leu Glu 
            340                 345                 350         


Xaa Arg Arg Cys Val Glu Ala Arg Leu Arg Leu Glu Xaa Glu Asn Gln 
        355                 360                 365             


Arg Gln Glu Arg Leu Val Leu Ser Val Leu Pro Arg Phe Val Val Leu 
    370                 375                 380                 


Glu Met Ile Asn Asp Met Xaa Asn Val Glu Asp Glu His Leu Gln His 
385                 390                 395                 400 


Gln Phe His Arg Ile Tyr Ile His Arg Tyr Glu Asn Val Ser Ile Leu 
                405                 410                 415     


Phe Ala Asp Val Lys Gly Phe Xaa Asn Leu Ser Xaa Xaa Leu Ser Ala 
            420                 425                 430         


Gln Glu Leu Val Arg Met Leu Asn Glu Leu Phe Ala Arg Phe Asp Arg 
        435                 440                 445             


Leu Ala His Glu His His Cys Leu Arg Ile Lys Ile Leu Gly Asp Cys 
    450                 455                 460                 


Tyr Tyr Cys Val Ser Gly Leu Pro Glu Pro Arg Gln Asp His Ala His 
465                 470                 475                 480 


Cys Cys Val Glu Met Gly Leu Ser Met Ile Lys Xaa Ile Arg Tyr Val 
                485                 490                 495     


Arg Ser Arg Xaa Lys His Asp Val Asp Met Arg Ile Gly Ile His Ser 
            500                 505                 510         


Gly Ser Val Leu Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Phe Asp 
        515                 520                 525             


Val Trp Ser Trp Asp Val Asp Ile Ala Asn Lys Leu Glu Ser Gly Gly 
    530                 535                 540                 


Ile Pro Gly Arg Ile His Ile Ser Lys Ala Xaa Leu Asp Cys Leu Asn 
545                 550                 555                 560 


Gly Asp Tyr Asn Val Glu Glu Gly His Gly Lys Glu Arg Asn Glu Phe 
                565                 570                 575     


Leu Arg Lys His Asn Ile Glu Xaa Tyr Leu Ile Lys Gln Pro Glu Asp 
            580                 585                 590         


Ser Leu Leu Ser Leu Pro Glu Asp Ile Val Lys Glu Ser Val Ser Ser 
        595                 600                 605             


Ser Asp Arg Arg Asn Ser Gly Ala Xaa Phe Xaa Glu Gly Ser Trp Ser 
    610                 615                 620                 


Pro Glu Leu Pro Phe Asp Asn Ile Val Gly Lys Gln Asn Xaa Leu Ala 
625                 630                 635                 640 


Ala Leu Xaa Arg Asn Ser Ile Asn Leu Leu Pro Asn His Leu Ala Gln 
                645                 650                 655     


Ala Leu His Val Gln Ser Gly Pro Glu Glu Ile Asn Lys Arg Ile Glu 
            660                 665                 670         


His Xaa Ile Asp Leu Arg Ser Gly Asp Lys Leu Arg Arg Glu His Ile 
        675                 680                 685             


Lys Pro Phe Ser Leu Met Phe Lys Asp Ser Ser Leu Glu His Lys Tyr 
    690                 695                 700                 


Ser Gln Met Arg Asp Glu Val Phe Lys Ser Asn Leu Val Cys Ala Phe 
705                 710                 715                 720 


Ile Val Leu Leu Phe Ile Xaa Ala Ile Gln Ser Leu Leu Pro Ser Ser 
                725                 730                 735     


Arg Val Met Pro Met Xaa Ile Gln Phe Ser Ile Leu Ile Met Leu His 
            740                 745                 750         


Ser Ala Leu Val Leu Ile Xaa Xaa Ala Glu Asp Tyr Lys Cys Leu Pro 
        755                 760                 765             


Leu Ile Leu Arg Lys Xaa Cys Cys Trp Ile Asn Glu Xaa Tyr Leu Ala 
    770                 775                 780                 


Arg Asn Val Ile Ile Phe Ala Ser Ile Leu Ile Asn Phe Leu Gly Ala 
785                 790                 795                 800 


Ile Leu Asn Ile Leu Trp Cys Asp Phe Asp Lys Ser Ile Pro Leu Lys 
                805                 810                 815     


Asn Leu Xaa Phe Asn Ser Ser Ala Val Phe Xaa Asp Ile Cys Ser Tyr 
            820                 825                 830         


Pro Glu Tyr Phe Val Phe Xaa Gly Val Leu Ala Met Val Xaa Cys Ala 
        835                 840                 845             


Val Phe Leu Arg Leu Asn Ser Val Leu Lys Leu Ala Val Leu Leu Ile 
    850                 855                 860                 


Met Ile Ala Ile Tyr Ala Leu Leu Xaa Glu Xaa Val Tyr Ala Gly Leu 
865                 870                 875                 880 


Phe Leu Arg Tyr Asp Asn Leu Asn His Ser Gly Glu Asp Phe Leu Gly 
                885                 890                 895     


Xaa Lys Glu Val Ser Leu Leu Leu Met Ala Met Phe Leu Leu Ala Val 
            900                 905                 910         


Phe Tyr His Gly Gln Gln Leu Glu Tyr Xaa Ala Arg Leu Asp Phe Leu 
        915                 920                 925             


Trp Arg Val Gln Ala Lys Glu Glu Ile Asn Glu Met Lys Glu Leu Arg 
    930                 935                 940                 


Glu His Asn Glu Asn Met Leu Arg Asn Ile Leu Pro Ser His Val Ala 
945                 950                 955                 960 


Arg His Phe Leu Glu Lys Asp Arg Asp Asn Glu Glu Leu Tyr Ser Gln 
                965                 970                 975     


Ser Tyr Asp Ala Val Gly Val Met Phe Ala Ser Ile Pro Gly Phe Ala 
            980                 985                 990         


Asp Phe Tyr Ser Gln Xaa Glu Met  Asn Asn Gln Gly Val  Glu Cys Leu 
        995                 1000                 1005             


Arg Leu  Leu Asn Glu Ile Ile  Ala Asp Phe Asp Glu  Leu Leu Gly 
    1010                 1015                 1020             


Glu Asp  Arg Phe Gln Asp Ile  Glu Lys Ile Lys Xaa  Ile Gly Ser 
    1025                 1030                 1035             


Xaa Tyr  Met Ala Val Ser Gly  Leu Ser Pro Glu Lys  Gln Gln Cys 
    1040                 1045                 1050             


Glu Asp  Lys Trp Gly His Leu  Cys Ala Leu Ala Asp  Phe Ser Leu 
    1055                 1060                 1065             


Ala Leu  Xaa Glu Ser Ile Gln  Glu Ile Asn Lys His  Ser Phe Asn 
    1070                 1075                 1080             


Asn Phe  Glu Leu Arg Ile Gly  Ile Ser His Gly Ser  Val Val Ala 
    1085                 1090                 1095             


Gly Val  Ile Gly Ala Lys Lys  Pro Gln Tyr Asp Ile  Trp Gly Lys 
    1100                 1105                 1110             


Xaa Val  Asn Leu Ala Ser Arg  Met Asp Ser Xaa Gly  Val Ser Gly 
    1115                 1120                 1125             


Arg Ile  Gln Val Pro Glu Glu  Xaa Tyr Leu Ile Leu  Lys Asp Gln 
    1130                 1135                 1140             


Gly Phe  Ala Phe Asp Tyr Arg  Gly Glu Ile Tyr Val  Lys Gly Ile 
    1145                 1150                 1155             


Ser Glu  Gln Glu Gly Lys Ile  Lys Xaa Tyr Phe Leu  Leu Gly Arg 
    1160                 1165                 1170             


Val Gln  Pro Asn Pro Phe Ile  Leu Pro Pro Arg Arg  Leu Pro Gly 
    1175                 1180                 1185             


Gln Tyr  Ser Leu Ala Ala Val  Val Leu Gly Leu Val  Gln Ser Leu 
    1190                 1195                 1200             


Asn Arg  Gln Arg Gln Lys Gln  Leu Leu Asn Glu Asn  Asn Asn Xaa 
    1205                 1210                 1215             


Gly Ile  Ile Lys Gly His Tyr  Asn Arg Arg Xaa Leu  Leu Ser Pro 
    1220                 1225                 1230             


Ser Gly  Xaa Glu Pro Gly Ala  Gln Ala Glu Gly Xaa  Asp Lys Ser 
    1235                 1240                 1245             


Asp Leu  Pro 
    1250     


<210> 1591
<211> 252
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<400> 1591
Met Ile Asn Asp Met Xaa Asn Val Glu Asp Glu His Leu Gln His Gln 
1               5                   10                  15      


Phe His Arg Ile Tyr Ile His Arg Tyr Glu Asn Val Ser Ile Leu Phe 
            20                  25                  30          


Ala Asp Val Lys Gly Phe Xaa Asn Leu Ser Xaa Xaa Leu Ser Ala Gln 
        35                  40                  45              


Glu Leu Val Arg Met Leu Asn Glu Leu Phe Ala Arg Phe Asp Arg Leu 
    50                  55                  60                  


Ala His Glu His His Cys Leu Arg Ile Lys Ile Leu Gly Asp Cys Tyr 
65                  70                  75                  80  


Tyr Cys Val Ser Gly Leu Pro Glu Pro Arg Gln Asp His Ala His Cys 
                85                  90                  95      


Cys Val Glu Met Gly Leu Ser Met Ile Lys Xaa Ile Arg Tyr Val Arg 
            100                 105                 110         


Ser Arg Xaa Lys His Asp Val Asp Met Arg Ile Gly Ile His Ser Gly 
        115                 120                 125             


Ser Val Leu Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Phe Asp Val 
    130                 135                 140                 


Trp Ser Trp Asp Val Asp Ile Ala Asn Lys Leu Glu Ser Gly Gly Ile 
145                 150                 155                 160 


Pro Gly Arg Ile His Ile Ser Lys Ala Xaa Leu Asp Cys Leu Asn Gly 
                165                 170                 175     


Asp Tyr Asn Val Glu Glu Gly His Gly Lys Glu Arg Asn Glu Phe Leu 
            180                 185                 190         


Arg Lys His Asn Ile Glu Xaa Tyr Leu Ile Lys Gln Pro Glu Asp Ser 
        195                 200                 205             


Leu Leu Ser Leu Pro Glu Asp Ile Val Lys Glu Ser Val Ser Ser Ser 
    210                 215                 220                 


Asp Arg Arg Asn Ser Gly Ala Xaa Phe Xaa Glu Gly Ser Trp Ser Pro 
225                 230                 235                 240 


Glu Leu Pro Phe Asp Asn Ile Val Gly Lys Gln Asn 
                245                 250         


<210> 1592
<211> 257
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<400> 1592
Ile Glu Gln Phe Cys Gln Glu Lys Lys Glu Met Val Asn Met Arg Val 
1               5                   10                  15      


Gly Val His Xaa Gly Xaa Val Leu Cys Gly Ile Leu Gly Met Arg Arg 
            20                  25                  30          


Phe Lys Phe Asp Val Trp Ser Asn Asp Val Asn Leu Ala Asn Leu Met 
        35                  40                  45              


Glu Gln Leu Gly Val Ala Gly Lys Val His Ile Ser Glu Ala Xaa Ala 
    50                  55                  60                  


Lys Tyr Leu Asp Asp Arg Tyr Glu Met Glu Asp Gly Lys Val Ile Glu 
65                  70                  75                  80  


Arg Leu Gly Gln Ser Val Val Ala Asp Gln Leu Lys Gly Leu Lys Xaa 
                85                  90                  95      


Tyr Leu Ile Ser Gly Gln Arg Ala Lys Glu Ser Arg Cys Ser Cys Ala 
            100                 105                 110         


Glu Ala Leu Leu Ser Gly Phe Glu Val Ile Asp Gly Ser Gln Val Ser 
        115                 120                 125             


Ser Gly Pro Arg Gly Gln Gly Xaa Ala Ser Ser Gly Asn Val Ser Asp 
    130                 135                 140                 


Leu Ala Gln Xaa Val Lys Xaa Phe Asp Asn Leu Lys Xaa Cys Pro Ser 
145                 150                 155                 160 


Cys Gly Ile Xaa Phe Ala Pro Lys Ser Glu Ala Gly Ala Glu Gly Gly 
                165                 170                 175     


Ala Pro Gln Asn Gly Cys Gln Asp Glu His Lys Asn Ser Xaa Lys Val 
            180                 185                 190         


Xaa Ser Ser Trp Leu Leu Phe Leu Ser Val Pro Leu Leu Ala His Pro 
        195                 200                 205             


Pro Lys Ala Ser Gly Gly Pro Asn Pro Lys Xaa Gln Asn Gly Leu Leu 
    210                 215                 220                 


Ser Pro Pro Gln Glu Glu Lys Leu Xaa Asn Ser Gln Xaa Ser Leu Cys 
225                 230                 235                 240 


Glu Ile Leu Gln Glu Lys Gly Arg Trp Ala Gly Val Ser Leu Asp Gln 
                245                 250                 255     


Ser 
    


<210> 1593
<211> 1353
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1173)..(1173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1179)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1190)..(1190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1246)..(1246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1291)..(1291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1299)..(1299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<400> 1593
Met Ala Ser Pro Pro His Gln Gln Leu Leu His His His Ser Xaa Glu 
1               5                   10                  15      


Val Ser Cys Asp Ser Ser Gly Asp Ser Asn Ser Val Arg Val Lys Ile 
            20                  25                  30          


Asn Pro Lys Gln Leu Ser Ser Asn Ser His Pro Lys His Cys Lys Tyr 
        35                  40                  45              


Ser Ile Ser Ser Ser Cys Ser Ser Ser Gly Asp Ser Gly Gly Val Pro 
    50                  55                  60                  


Arg Arg Val Gly Gly Gly Gly Arg Leu Arg Arg Gln Lys Lys Leu Pro 
65                  70                  75                  80  


Gln Leu Phe Glu Arg Ala Ser Ser Arg Trp Trp Asp Pro Lys Phe Asp 
                85                  90                  95      


Ser Val Asn Leu Glu Glu Ala Cys Leu Glu Arg Cys Phe Pro Gln Xaa 
            100                 105                 110         


Gln Arg Arg Phe Arg Tyr Ala Leu Phe Tyr Ile Gly Phe Ala Cys Leu 
        115                 120                 125             


Leu Trp Ser Ile Tyr Phe Ala Val His Met Arg Ser Arg Leu Ile Val 
    130                 135                 140                 


Met Val Ala Pro Ala Leu Cys Phe Leu Leu Val Cys Val Gly Phe Phe 
145                 150                 155                 160 


Leu Phe Xaa Phe Xaa Lys Leu Tyr Ala Arg His Tyr Ala Trp Xaa Ser 
                165                 170                 175     


Leu Ala Leu Xaa Leu Leu Val Phe Ala Leu Xaa Leu Ala Ala Gln Phe 
            180                 185                 190         


Gln Val Leu Xaa Pro Val Ser Gly Arg Gly Asp Ser Ser Asn Leu Xaa 
        195                 200                 205             


Ala Xaa Ala Arg Pro Xaa Asp Xaa Cys Leu Ser Gln Val Gly Ser Phe 
    210                 215                 220                 


Ser Met Cys Ile Glu Val Leu Phe Leu Leu Tyr Xaa Val Met His Leu 
225                 230                 235                 240 


Pro Leu Tyr Leu Ser Leu Cys Leu Gly Val Ala Tyr Ser Val Leu Phe 
                245                 250                 255     


Glu Xaa Phe Gly Tyr His Phe Arg Asp Glu Ala Cys Phe Pro Ser Pro 
            260                 265                 270         


Gly Ala Gly Ala Leu His Trp Glu Leu Leu Ser Arg Gly Leu Leu His 
        275                 280                 285             


Gly Cys Ile His Ala Ile Gly Val His Leu Phe Val Met Ser Gln Val 
    290                 295                 300                 


Arg Ser Arg Ser Xaa Phe Leu Lys Val Gly Gln Ser Ile Met His Gly 
305                 310                 315                 320 


Lys Asp Leu Glu Val Glu Lys Ala Leu Lys Glu Arg Met Ile His Ser 
                325                 330                 335     


Val Met Pro Arg Ile Ile Ala Asp Asp Leu Met Lys Gln Gly Asp Glu 
            340                 345                 350         


Glu Ser Glu Asn Ser Val Lys Arg His Ala Xaa Ser Ser Pro Lys Asn 
        355                 360                 365             


Arg Lys Lys Lys Ser Ser Ile Gln Lys Ala Pro Ile Ala Phe Arg Pro 
    370                 375                 380                 


Phe Lys Met Gln Gln Ile Glu Glu Val Ser Ile Leu Phe Ala Asp Ile 
385                 390                 395                 400 


Val Gly Phe Xaa Lys Met Ser Ala Asn Lys Ser Ala His Ala Leu Val 
                405                 410                 415     


Gly Leu Leu Asn Asp Leu Phe Gly Arg Phe Asp Arg Leu Cys Glu Glu 
            420                 425                 430         


Xaa Lys Cys Glu Lys Ile Ser Xaa Leu Gly Asp Cys Tyr Tyr Cys Val 
        435                 440                 445             


Ala Gly Cys Pro Glu Pro Arg Ala Asp His Ala Tyr Cys Cys Ile Glu 
    450                 455                 460                 


Met Gly Leu Gly Met Ile Lys Ala Ile Glu Gln Phe Cys Gln Glu Lys 
465                 470                 475                 480 


Lys Glu Met Val Asn Met Arg Val Gly Val His Xaa Gly Xaa Val Leu 
                485                 490                 495     


Cys Gly Ile Leu Gly Met Arg Arg Phe Lys Phe Asp Val Trp Ser Asn 
            500                 505                 510         


Asp Val Asn Leu Ala Asn Leu Met Glu Gln Leu Gly Val Ala Gly Lys 
        515                 520                 525             


Val His Ile Ser Glu Ala Xaa Ala Lys Tyr Leu Asp Asp Arg Tyr Glu 
    530                 535                 540                 


Met Glu Asp Gly Lys Val Ile Glu Arg Leu Gly Gln Ser Val Val Ala 
545                 550                 555                 560 


Asp Gln Leu Lys Gly Leu Lys Xaa Tyr Leu Ile Ser Gly Gln Arg Ala 
                565                 570                 575     


Lys Glu Ser Arg Cys Ser Cys Ala Glu Ala Leu Leu Ser Gly Phe Glu 
            580                 585                 590         


Val Ile Asp Gly Ser Gln Val Ser Ser Gly Pro Arg Gly Gln Gly Xaa 
        595                 600                 605             


Ala Ser Ser Gly Asn Val Ser Asp Leu Ala Gln Xaa Val Lys Xaa Phe 
    610                 615                 620                 


Asp Asn Leu Lys Xaa Cys Pro Ser Cys Gly Ile Xaa Phe Ala Pro Lys 
625                 630                 635                 640 


Ser Glu Ala Gly Ala Glu Gly Gly Ala Pro Gln Asn Gly Cys Gln Asp 
                645                 650                 655     


Glu His Lys Asn Ser Xaa Lys Ala Ser Gly Gly Pro Asn Pro Lys Xaa 
            660                 665                 670         


Gln Asn Gly Leu Leu Ser Pro Pro Gln Glu Glu Lys Leu Xaa Asn Ser 
        675                 680                 685             


Gln Xaa Ser Leu Cys Glu Ile Leu Gln Glu Lys Gly Arg Trp Ala Gly 
    690                 695                 700                 


Val Ser Leu Asp Gln Ser Ala Leu Leu Pro Leu Arg Phe Lys Asn Ile 
705                 710                 715                 720 


Arg Glu Lys Xaa Asp Ala His Phe Val Asp Val Ile Lys Glu Asp Ser 
                725                 730                 735     


Leu Met Lys Asp Tyr Phe Phe Lys Pro Pro Ile Asn Gln Phe Ser Leu 
            740                 745                 750         


Asn Phe Leu Asp Gln Glu Leu Glu Arg Ser Tyr Arg Xaa Ser Tyr Gln 
        755                 760                 765             


Glu Glu Val Ile Lys Asn Ser Pro Val Lys Xaa Phe Ala Ser Pro Xaa 
    770                 775                 780                 


Phe Ser Ser Leu Leu Asp Val Phe Leu Ser Xaa Xaa Val Phe Leu Xaa 
785                 790                 795                 800 


Leu Ser Xaa Xaa Cys Phe Leu Lys Tyr Glu Ala Ala Xaa Val Pro Pro 
                805                 810                 815     


Pro Pro Ala Ala Leu Ala Val Phe Ser Ala Ala Leu Leu Leu Glu Val 
            820                 825                 830         


Leu Ser Leu Ala Val Ser Ile Arg Met Val Phe Phe Leu Glu Asp Val 
        835                 840                 845             


Met Ala Cys Xaa Lys Arg Leu Leu Glu Trp Ile Ala Gly Trp Leu Pro 
    850                 855                 860                 


Arg His Cys Ile Gly Ala Ile Leu Val Ser Leu Pro Ala Leu Ala Val 
865                 870                 875                 880 


Tyr Ser His Val Xaa Ser Glu Tyr Glu Xaa Asn Ile His Phe Pro Val 
                885                 890                 895     


Phe Xaa Gly Ser Ala Ala Leu Ile Ala Val Val His Tyr Cys Asn Phe 
            900                 905                 910         


Cys Gln Leu Ser Ser Trp Met Arg Ser Ser Leu Ala Xaa Val Val Gly 
        915                 920                 925             


Ala Gly Pro Leu Leu Leu Leu Tyr Val Ser Leu Cys Pro Asp Ser Ser 
    930                 935                 940                 


Val Leu Xaa Ser Pro Leu Asp Ala Val Gln Asn Phe Ser Ser Glu Arg 
945                 950                 955                 960 


Asn Pro Cys Asn Ser Ser Val Pro Arg Asp Leu Arg Arg Pro Ala Ser 
                965                 970                 975     


Leu Ile Gly Gln Glu Val Val Leu Val Phe Phe Leu Leu Leu Leu Leu 
            980                 985                 990         


Val Trp Phe Leu Asn Arg Glu Phe  Glu Val Ser Tyr Arg  Leu His Tyr 
        995                 1000                 1005             


His Gly  Asp Val Glu Ala Asp  Leu His Arg Xaa Lys  Ile Gln Ser 
    1010                 1015                 1020             


Met Arg  Asp Gln Ala Asp Trp  Leu Leu Arg Asn Ile  Ile Pro Tyr 
    1025                 1030                 1035             


His Val  Ala Glu Gln Leu Lys  Val Ser Gln Xaa Tyr  Ser Lys Asn 
    1040                 1045                 1050             


His Asp  Ser Gly Gly Val Ile  Phe Ala Ser Ile Val  Asn Phe Ser 
    1055                 1060                 1065             


Glu Phe  Tyr Glu Glu Asn Tyr  Glu Gly Gly Lys Glu  Cys Tyr Arg 
    1070                 1075                 1080             


Val Leu  Asn Glu Leu Ile Gly  Asp Phe Asp Glu Leu  Leu Ser Lys 
    1085                 1090                 1095             


Pro Asp  Tyr Ser Ser Ile Glu  Lys Ile Lys Xaa Ile  Gly Ala Xaa 
    1100                 1105                 1110             


Tyr Met  Ala Ala Ser Gly Leu  Asn Xaa Ala Gln Ala  Gln Asp Gly 
    1115                 1120                 1125             


Ser His  Pro Gln Glu His Leu  Gln Ile Leu Phe Glu  Phe Ala Lys 
    1130                 1135                 1140             


Glu Met  Met Arg Val Val Asp  Asp Phe Asn Asn Asn  Met Leu Trp 
    1145                 1150                 1155             


Phe Asn  Phe Lys Leu Arg Val  Gly Phe Asn His Gly  Pro Leu Xaa 
    1160                 1165                 1170             


Ala Gly  Val Ile Gly Xaa Xaa  Lys Leu Leu Tyr Asp  Ile Trp Gly 
    1175                 1180                 1185             


Asp Xaa  Val Asn Ile Ala Ser  Arg Met Asp Xaa Xaa  Gly Val Glu 
    1190                 1195                 1200             


Cys Arg  Ile Gln Val Ser Glu  Glu Ser Tyr Arg Val  Leu Ser Lys 
    1205                 1210                 1215             


Met Gly  Tyr Asp Phe Asp Tyr  Arg Gly Xaa Val Asn  Val Lys Gly 
    1220                 1225                 1230             


Lys Gly  Gln Met Lys Xaa Tyr  Leu Tyr Pro Lys Cys  Xaa Asp His 
    1235                 1240                 1245             


Arg Val  Ile Pro Gln His Gln  Leu Ser Ile Ser Pro  Asp Ile Arg 
    1250                 1255                 1260             


Val Gln  Val Asp Gly Ser Ile  Gly Arg Ser Pro Xaa  Asp Glu Ile 
    1265                 1270                 1275             


Ala Asn  Leu Val Pro Ser Val  Gln Tyr Val Asp Lys  Xaa Ser Leu 
    1280                 1285                 1290             


Gly Ser  Asp Ser Ser Xaa Gln  Ala Lys Asp Ala His  Leu Ser Pro 
    1295                 1300                 1305             


Lys Arg  Pro Trp Lys Glu Pro  Val Lys Ala Glu Glu  Arg Gly Arg 
    1310                 1315                 1320             


Phe Gly  Lys Ala Ile Glu Lys  Asp Asp Cys Asp Glu  Xaa Gly Ile 
    1325                 1330                 1335             


Glu Glu  Ala Asn Glu Leu Xaa  Lys Leu Asn Val Ser  Lys Ser Val 
    1340                 1345                 1350             


<210> 1594
<211> 215
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<400> 1594
Xaa Glu Glu Val Ile Lys Asn Ser Pro Val Lys Xaa Phe Ala Ser Pro 
1               5                   10                  15      


Xaa Phe Ser Ser Leu Leu Asp Val Phe Leu Ser Xaa Xaa Val Phe Leu 
            20                  25                  30          


Xaa Leu Ser Xaa Xaa Cys Phe Leu Lys Tyr Glu Ala Ala Xaa Val Pro 
        35                  40                  45              


Pro Pro Pro Ala Ala Leu Ala Val Phe Ser Ala Ala Leu Leu Leu Glu 
    50                  55                  60                  


Val Leu Ser Leu Ala Val Ser Ile Arg Met Val Phe Phe Leu Glu Asp 
65                  70                  75                  80  


Val Met Ala Cys Xaa Lys Arg Leu Leu Glu Trp Ile Ala Gly Trp Leu 
                85                  90                  95      


Pro Arg His Cys Ile Gly Ala Ile Leu Val Ser Leu Pro Ala Leu Ala 
            100                 105                 110         


Val Tyr Ser His Val Xaa Ser Glu Tyr Glu Xaa Asn Ile His Phe Pro 
        115                 120                 125             


Val Phe Xaa Gly Ser Ala Ala Leu Ile Ala Val Val His Tyr Cys Asn 
    130                 135                 140                 


Phe Cys Gln Leu Ser Ser Trp Met Arg Ser Ser Leu Ala Xaa Val Val 
145                 150                 155                 160 


Gly Ala Gly Pro Leu Leu Leu Leu Tyr Val Ser Leu Cys Pro Asp Ser 
                165                 170                 175     


Ser Val Leu Xaa Ser Pro Leu Asp Ala Val Gln Asn Phe Arg Arg Arg 
            180                 185                 190         


Glu Pro Cys Gly Glu Gly Asp Ser Lys Phe Pro Phe Ser Ser Gln Glu 
        195                 200                 205             


Glu Ser Cys Arg Ala Gly Ala 
    210                 215 


<210> 1595
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<400> 1595
Xaa Phe Asp Val Trp Ser Asn Asp Val Asn Leu Ala Asn Leu Met Glu 
1               5                   10                  15      


Gln Leu Gly Val Ala Gly Lys Val His Ile Ser Glu Ala Xaa Ala Lys 
            20                  25                  30          


Tyr Leu Asp Asp Arg Tyr Glu Met Glu Asp Gly Lys Val Ile Glu Arg 
        35                  40                  45              


Leu Gly Gln Ser Val Val Ala Asp Gln Leu Lys Asp Leu Pro Phe Val 
    50                  55                  60                  


Arg Asn His Ile Cys Ser Gln Ile 
65                  70          


<210> 1596
<211> 176
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<400> 1596
Met Xaa Met Cys Ser Gly Ala Arg Leu Ala Leu Leu Val Tyr Gly Ile 
1               5                   10                  15      


Ile Met His Ser Ser Val Tyr Ser Ser Pro Ala Ala Ala Gly Leu Arg 
            20                  25                  30          


Phe Pro Gly Ile Arg Pro Glu Glu Glu Ala Tyr Gly Glu Asp Gly Asn 
        35                  40                  45              


Pro Leu Pro Asp Phe Asp Gly Ser Glu Pro Pro Gly Ala Gly Ser Pro 
    50                  55                  60                  


Ala Ser Ala Pro Arg Ala Ala Ala Ala Trp Tyr Arg Pro Ala Gly Arg 
65                  70                  75                  80  


Arg Asp Val Ala His Gly Ile Leu Asn Glu Ala Tyr Arg Lys Val Leu 
                85                  90                  95      


Asp Gln Leu Ser Ala Gly Lys His Leu Gln Ser Leu Val Ala Arg Gly 
            100                 105                 110         


Val Gly Gly Ser Leu Gly Gly Gly Ala Gly Asp Asp Ala Glu Pro Leu 
        115                 120                 125             


Ser Lys Arg His Ser Asp Gly Ile Phe Xaa Asp Ser Tyr Ser Arg Tyr 
    130                 135                 140                 


Arg Lys Gln Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys 
145                 150                 155                 160 


Arg Tyr Lys Gln Arg Val Lys Asn Lys Gly Arg Arg Ile Ala Tyr Leu 
                165                 170                 175     


<210> 1597
<211> 74
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<400> 1597
Met Ala Gly Val Val His Val Ser Leu Ala Ala Leu Leu Leu Leu Pro 
1               5                   10                  15      


Met Ala Pro Ala Met His Ser Asp Cys Ile Phe Lys Lys Glu Gln Ala 
            20                  25                  30          


Met Cys Leu Glu Lys Ile Gln Arg Ala Asn Glu Leu Met Gly Phe Asn 
        35                  40                  45              


Asp Ser Ser Pro Gly Cys Pro Gly Met Trp Asp Asn Ile Xaa Cys Trp 
    50                  55                  60                  


Lys Pro Ala His Val Gly Glu Met Val Leu 
65                  70                  


<210> 1598
<211> 447
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<400> 1598
Met Ala Gly Val Val His Val Ser Leu Ala Ala Leu Leu Leu Leu Pro 
1               5                   10                  15      


Met Ala Pro Ala Met His Ser Asp Cys Ile Phe Lys Lys Glu Gln Ala 
            20                  25                  30          


Met Cys Leu Glu Lys Ile Gln Arg Ala Asn Glu Leu Met Gly Phe Asn 
        35                  40                  45              


Asp Ser Ser Pro Gly Cys Pro Gly Met Trp Asp Asn Ile Xaa Cys Trp 
    50                  55                  60                  


Lys Pro Ala His Val Gly Glu Met Val Leu Val Ser Cys Pro Glu Leu 
65                  70                  75                  80  


Phe Arg Ile Phe Asn Pro Asp Gln Asp Met Gly Val Val Ser Arg Asn 
                85                  90                  95      


Cys Xaa Glu Asp Gly Trp Ser Glu Pro Phe Pro His Tyr Phe Asp Ala 
            100                 105                 110         


Cys Gly Phe Asp Glu Tyr Glu Ser Glu Xaa Gly Asp Gln Asp Tyr Tyr 
        115                 120                 125             


Tyr Leu Ser Val Lys Ala Leu Tyr Xaa Val Gly Tyr Ser Xaa Ser Leu 
    130                 135                 140                 


Val Xaa Leu Xaa Xaa Ala Met Val Ile Leu Cys Arg Phe Arg Lys Leu 
145                 150                 155                 160 


His Cys Xaa Arg Asn Phe Ile His Met Asn Leu Phe Val Ser Phe Met 
                165                 170                 175     


Leu Arg Ala Ile Ser Val Phe Ile Lys Asp Trp Ile Leu Tyr Ala Glu 
            180                 185                 190         


Gln Asp Ser Asn His Cys Phe Ile Ser Xaa Val Glu Cys Lys Ala Val 
        195                 200                 205             


Met Val Phe Phe His Tyr Cys Val Val Ser Asn Tyr Phe Trp Leu Phe 
    210                 215                 220                 


Ile Glu Gly Leu Tyr Leu Phe Xaa Leu Leu Val Glu Xaa Phe Phe Pro 
225                 230                 235                 240 


Glu Arg Arg Tyr Phe Tyr Trp Tyr Xaa Ile Ile Gly Trp Gly Xaa Pro 
                245                 250                 255     


Xaa Val Cys Val Xaa Val Trp Ala Xaa Leu Arg Leu Tyr Phe Asp Asp 
            260                 265                 270         


Xaa Gly Cys Trp Asp Met Asn Asp Ser Xaa Ala Leu Trp Trp Val Ile 
        275                 280                 285             


Lys Gly Pro Val Val Gly Ser Ile Met Val Asn Phe Val Leu Phe Ile 
    290                 295                 300                 


Gly Ile Ile Val Ile Leu Val Gln Lys Leu Gln Ser Pro Asp Met Gly 
305                 310                 315                 320 


Gly Asn Glu Ser Ser Ile Tyr Leu Arg Leu Ala Arg Ser Xaa Leu Leu 
                325                 330                 335     


Leu Ile Pro Leu Phe Gly Ile His Tyr Xaa Val Phe Ala Phe Ser Pro 
            340                 345                 350         


Glu Asn Val Ser Lys Arg Glu Arg Leu Val Phe Glu Leu Gly Leu Gly 
        355                 360                 365             


Ser Phe Gln Gly Phe Val Val Ala Val Leu Tyr Cys Phe Leu Asn Gly 
    370                 375                 380                 


Glu Val Gln Ala Glu Ile Lys Arg Lys Trp Arg Ser Trp Lys Val Asn 
385                 390                 395                 400 


Arg Tyr Phe Ala Val Asp Phe Lys His Arg His Pro Ser Leu Ala Ser 
                405                 410                 415     


Ser Gly Val Asn Gly Gly Xaa Gln Leu Ser Ile Leu Ser Lys Ser Ser 
            420                 425                 430         


Ser Gln Ile Arg Met Ser Gly Leu Pro Ala Asp Asn Leu Ala Xaa 
        435                 440                 445         


<210> 1599
<211> 468
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<400> 1599
Met Ala Gly Val Val His Val Ser Leu Ala Ala Leu Leu Leu Leu Pro 
1               5                   10                  15      


Met Ala Pro Ala Met His Ser Asp Cys Ile Phe Lys Lys Glu Gln Ala 
            20                  25                  30          


Met Cys Leu Glu Lys Ile Gln Arg Ala Asn Glu Leu Met Gly Phe Asn 
        35                  40                  45              


Asp Ser Ser Pro Gly Cys Pro Gly Met Trp Asp Asn Ile Xaa Cys Trp 
    50                  55                  60                  


Lys Pro Ala His Val Gly Glu Met Val Leu Val Ser Cys Pro Glu Leu 
65                  70                  75                  80  


Phe Arg Ile Phe Asn Pro Asp Gln Val Trp Glu Xaa Glu Xaa Ile Gly 
                85                  90                  95      


Glu Ser Asp Phe Gly Asp Ser Asn Ser Leu Asp Leu Ser Asp Met Gly 
            100                 105                 110         


Val Val Ser Arg Asn Cys Xaa Glu Asp Gly Trp Ser Glu Pro Phe Pro 
        115                 120                 125             


His Tyr Phe Asp Ala Cys Gly Phe Asp Glu Tyr Glu Ser Glu Xaa Gly 
    130                 135                 140                 


Asp Gln Asp Tyr Tyr Tyr Leu Ser Val Lys Ala Leu Tyr Xaa Val Gly 
145                 150                 155                 160 


Tyr Ser Xaa Ser Leu Val Xaa Leu Xaa Xaa Ala Met Val Ile Leu Cys 
                165                 170                 175     


Arg Phe Arg Lys Leu His Cys Xaa Arg Asn Phe Ile His Met Asn Leu 
            180                 185                 190         


Phe Val Ser Phe Met Leu Arg Ala Ile Ser Val Phe Ile Lys Asp Trp 
        195                 200                 205             


Ile Leu Tyr Ala Glu Gln Asp Ser Asn His Cys Phe Ile Ser Xaa Val 
    210                 215                 220                 


Glu Cys Lys Ala Val Met Val Phe Phe His Tyr Cys Val Val Ser Asn 
225                 230                 235                 240 


Tyr Phe Trp Leu Phe Ile Glu Gly Leu Tyr Leu Phe Xaa Leu Leu Val 
                245                 250                 255     


Glu Xaa Phe Phe Pro Glu Arg Arg Tyr Phe Tyr Trp Tyr Xaa Ile Ile 
            260                 265                 270         


Gly Trp Gly Xaa Pro Xaa Val Cys Val Xaa Val Trp Ala Xaa Leu Arg 
        275                 280                 285             


Leu Tyr Phe Asp Asp Xaa Gly Cys Trp Asp Met Asn Asp Ser Xaa Ala 
    290                 295                 300                 


Leu Trp Trp Val Ile Lys Gly Pro Val Val Gly Ser Ile Met Val Asn 
305                 310                 315                 320 


Phe Val Leu Phe Ile Gly Ile Ile Val Ile Leu Val Gln Lys Leu Gln 
                325                 330                 335     


Ser Pro Asp Met Gly Gly Asn Glu Ser Ser Ile Tyr Leu Arg Leu Ala 
            340                 345                 350         


Arg Ser Xaa Leu Leu Leu Ile Pro Leu Phe Gly Ile His Tyr Xaa Val 
        355                 360                 365             


Phe Ala Phe Ser Pro Glu Asn Val Ser Lys Arg Glu Arg Leu Val Phe 
    370                 375                 380                 


Glu Leu Gly Leu Gly Ser Phe Gln Gly Phe Val Val Ala Val Leu Tyr 
385                 390                 395                 400 


Cys Phe Leu Asn Gly Glu Val Gln Ala Glu Ile Lys Arg Lys Trp Arg 
                405                 410                 415     


Ser Trp Lys Val Asn Arg Tyr Phe Ala Val Asp Phe Lys His Arg His 
            420                 425                 430         


Pro Ser Leu Ala Ser Ser Gly Val Asn Gly Gly Xaa Gln Leu Ser Ile 
        435                 440                 445             


Leu Ser Lys Ser Ser Ser Gln Ile Arg Met Ser Gly Leu Pro Ala Asp 
    450                 455                 460                 


Asn Leu Ala Xaa 
465             


<210> 1600
<211> 496
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<400> 1600
Met Ala Gly Val Val His Val Ser Leu Ala Ala Leu Leu Leu Leu Pro 
1               5                   10                  15      


Met Ala Pro Ala Met His Ser Asp Cys Ile Phe Lys Lys Glu Gln Ala 
            20                  25                  30          


Met Cys Leu Glu Lys Ile Gln Arg Ala Asn Glu Leu Met Gly Phe Asn 
        35                  40                  45              


Asp Ser Ser Pro Gly Cys Pro Gly Met Trp Asp Asn Ile Xaa Cys Trp 
    50                  55                  60                  


Lys Pro Ala His Val Gly Glu Met Val Leu Val Ser Cys Pro Glu Leu 
65                  70                  75                  80  


Phe Arg Ile Phe Asn Pro Asp Gln Val Trp Glu Xaa Glu Xaa Ile Gly 
                85                  90                  95      


Glu Ser Asp Phe Gly Asp Ser Asn Ser Leu Asp Leu Ser Asp Met Gly 
            100                 105                 110         


Val Val Ser Arg Asn Cys Xaa Glu Asp Gly Trp Ser Glu Pro Phe Pro 
        115                 120                 125             


His Tyr Phe Asp Ala Cys Gly Phe Asp Glu Tyr Glu Ser Glu Xaa Gly 
    130                 135                 140                 


Asp Gln Asp Tyr Tyr Tyr Leu Ser Val Lys Ala Leu Tyr Xaa Val Gly 
145                 150                 155                 160 


Tyr Ser Xaa Ser Leu Val Xaa Leu Xaa Xaa Ala Met Val Ile Leu Cys 
                165                 170                 175     


Arg Phe Arg Lys Leu His Cys Xaa Arg Asn Phe Ile His Met Asn Leu 
            180                 185                 190         


Phe Val Ser Phe Met Leu Arg Ala Ile Ser Val Phe Ile Lys Asp Trp 
        195                 200                 205             


Ile Leu Tyr Ala Glu Gln Asp Ser Asn His Cys Phe Ile Ser Xaa Val 
    210                 215                 220                 


Glu Cys Lys Ala Val Met Val Phe Phe His Tyr Cys Val Val Ser Asn 
225                 230                 235                 240 


Tyr Phe Trp Leu Phe Ile Glu Gly Leu Tyr Leu Phe Xaa Leu Leu Val 
                245                 250                 255     


Glu Xaa Phe Phe Pro Glu Arg Arg Tyr Phe Tyr Trp Tyr Xaa Ile Ile 
            260                 265                 270         


Gly Trp Gly Xaa Pro Xaa Val Cys Val Xaa Val Trp Ala Xaa Leu Arg 
        275                 280                 285             


Leu Tyr Phe Asp Asp Xaa Gly Cys Trp Asp Met Asn Asp Ser Xaa Ala 
    290                 295                 300                 


Leu Trp Trp Val Ile Lys Gly Pro Val Val Gly Ser Ile Met Val Asn 
305                 310                 315                 320 


Phe Val Leu Phe Ile Gly Ile Ile Val Ile Leu Val Gln Lys Leu Gln 
                325                 330                 335     


Ser Pro Asp Met Gly Gly Asn Glu Ser Ser Ile Tyr Phe Ser Cys Val 
            340                 345                 350         


Gln Lys Cys Tyr Cys Lys Pro Gln Arg Ala Gln Gln His Ser Cys Lys 
        355                 360                 365             


Met Ser Glu Leu Ser Xaa Ile Xaa Leu Arg Leu Ala Arg Ser Xaa Leu 
    370                 375                 380                 


Leu Leu Ile Pro Leu Phe Gly Ile His Tyr Xaa Val Phe Ala Phe Ser 
385                 390                 395                 400 


Pro Glu Asn Val Ser Lys Arg Glu Arg Leu Val Phe Glu Leu Gly Leu 
                405                 410                 415     


Gly Ser Phe Gln Gly Phe Val Val Ala Val Leu Tyr Cys Phe Leu Asn 
            420                 425                 430         


Gly Glu Val Gln Ala Glu Ile Lys Arg Lys Trp Arg Ser Trp Lys Val 
        435                 440                 445             


Asn Arg Tyr Phe Ala Val Asp Phe Lys His Arg His Pro Ser Leu Ala 
    450                 455                 460                 


Ser Ser Gly Val Asn Gly Gly Xaa Gln Leu Ser Ile Leu Ser Lys Ser 
465                 470                 475                 480 


Ser Ser Gln Ile Arg Met Ser Gly Leu Pro Ala Asp Asn Leu Ala Xaa 
                485                 490                 495     


<210> 1601
<211> 524
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<400> 1601
Met Ala Gly Val Val His Val Ser Leu Ala Ala Leu Leu Leu Leu Pro 
1               5                   10                  15      


Met Ala Pro Ala Met His Ser Asp Cys Ile Phe Lys Lys Glu Gln Ala 
            20                  25                  30          


Met Cys Leu Glu Lys Ile Gln Arg Ala Asn Glu Leu Met Gly Phe Asn 
        35                  40                  45              


Asp Ser Ser Pro Gly Cys Pro Gly Met Trp Asp Asn Ile Xaa Cys Trp 
    50                  55                  60                  


Lys Pro Ala His Val Gly Glu Met Val Leu Val Ser Cys Pro Glu Leu 
65                  70                  75                  80  


Phe Arg Ile Phe Asn Pro Asp Gln Val Trp Glu Xaa Glu Xaa Ile Gly 
                85                  90                  95      


Glu Ser Asp Phe Gly Asp Ser Asn Ser Leu Asp Leu Ser Asp Met Gly 
            100                 105                 110         


Val Val Ser Arg Asn Cys Xaa Glu Asp Gly Trp Ser Glu Pro Phe Pro 
        115                 120                 125             


His Tyr Phe Asp Ala Cys Gly Phe Asp Glu Tyr Glu Ser Glu Xaa Gly 
    130                 135                 140                 


Asp Gln Asp Tyr Tyr Tyr Leu Ser Val Lys Ala Leu Tyr Xaa Val Gly 
145                 150                 155                 160 


Tyr Ser Xaa Ser Leu Val Xaa Leu Xaa Xaa Ala Met Val Ile Leu Cys 
                165                 170                 175     


Arg Phe Arg Lys Leu His Cys Xaa Arg Asn Phe Ile His Met Asn Leu 
            180                 185                 190         


Phe Val Ser Phe Met Leu Arg Ala Ile Ser Val Phe Ile Lys Asp Trp 
        195                 200                 205             


Ile Leu Tyr Ala Glu Gln Asp Ser Asn His Cys Phe Ile Ser Xaa Val 
    210                 215                 220                 


Glu Cys Lys Ala Val Met Val Phe Phe His Tyr Cys Val Val Ser Asn 
225                 230                 235                 240 


Tyr Phe Trp Leu Phe Ile Glu Gly Leu Tyr Leu Phe Xaa Leu Leu Val 
                245                 250                 255     


Glu Xaa Phe Phe Pro Glu Arg Arg Tyr Phe Tyr Trp Tyr Xaa Ile Ile 
            260                 265                 270         


Gly Trp Gly Xaa Pro Xaa Val Cys Val Xaa Val Trp Ala Xaa Leu Arg 
        275                 280                 285             


Leu Tyr Phe Asp Asp Xaa Gly Cys Trp Asp Met Asn Asp Ser Xaa Ala 
    290                 295                 300                 


Leu Trp Trp Val Ile Lys Gly Pro Val Val Gly Ser Ile Met Val Asn 
305                 310                 315                 320 


Phe Val Leu Phe Ile Gly Ile Ile Val Ile Leu Val Gln Lys Leu Gln 
                325                 330                 335     


Ser Pro Asp Met Gly Gly Asn Glu Ser Ser Ile Tyr Leu Xaa Asn Leu 
            340                 345                 350         


Ser Pro Arg Val Pro Lys Lys Ala Arg Glu Asp Pro Leu Pro Val Pro 
        355                 360                 365             


Ser Asp Gln His Ser Leu Pro Phe Leu Ser Cys Val Gln Lys Cys Tyr 
    370                 375                 380                 


Cys Lys Pro Gln Arg Ala Gln Gln His Ser Cys Lys Met Ser Glu Leu 
385                 390                 395                 400 


Ser Xaa Ile Xaa Leu Arg Leu Ala Arg Ser Xaa Leu Leu Leu Ile Pro 
                405                 410                 415     


Leu Phe Gly Ile His Tyr Xaa Val Phe Ala Phe Ser Pro Glu Asn Val 
            420                 425                 430         


Ser Lys Arg Glu Arg Leu Val Phe Glu Leu Gly Leu Gly Ser Phe Gln 
        435                 440                 445             


Gly Phe Val Val Ala Val Leu Tyr Cys Phe Leu Asn Gly Glu Val Gln 
    450                 455                 460                 


Ala Glu Ile Lys Arg Lys Trp Arg Ser Trp Lys Val Asn Arg Tyr Phe 
465                 470                 475                 480 


Ala Val Asp Phe Lys His Arg His Pro Ser Leu Ala Ser Ser Gly Val 
                485                 490                 495     


Asn Gly Gly Xaa Gln Leu Ser Ile Leu Ser Lys Ser Ser Ser Gln Ile 
            500                 505                 510         


Arg Met Ser Gly Leu Pro Ala Asp Asn Leu Ala Xaa 
        515                 520                 


<210> 1602
<211> 148
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<400> 1602
Xaa Ala Xaa Leu Arg Leu Tyr Phe Asp Asp Xaa Gly Cys Trp Asp Met 
1               5                   10                  15      


Asn Asp Ser Xaa Ala Leu Trp Trp Val Ile Lys Gly Pro Val Val Gly 
            20                  25                  30          


Ser Ile Met Val Asn Phe Val Leu Phe Ile Gly Ile Ile Val Ile Leu 
        35                  40                  45              


Val Gln Lys Leu Gln Ser Pro Asp Met Gly Gly Asn Glu Ser Ser Ile 
    50                  55                  60                  


Tyr Leu Xaa Asn Leu Ser Pro Arg Val Pro Lys Lys Ala Arg Glu Asp 
65                  70                  75                  80  


Pro Leu Pro Val Pro Ser Asp Gln His Ser Leu Pro Phe Leu Arg Leu 
                85                  90                  95      


Ala Arg Ser Xaa Leu Leu Leu Ile Pro Leu Phe Gly Ile His Tyr Xaa 
            100                 105                 110         


Val Phe Ala Phe Ser Pro Glu Asn Val Ser Lys Arg Glu Arg Leu Val 
        115                 120                 125             


Phe Glu Leu Gly Leu Gly Ser Phe Gln Gly Phe Val Val Ala Val Leu 
    130                 135                 140                 


Tyr Cys Phe Leu 
145             


<210> 1603
<211> 560
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(559)
<223> Selenocysteine

<400> 1603
Met Asp Leu Lys Xaa Val Leu Ser Leu Pro Arg Tyr Pro Gly Glu Phe 
1               5                   10                  15      


Leu His Pro Val Val Tyr Ala Cys Xaa Ala Val Met Leu Leu Cys Leu 
            20                  25                  30          


Leu Ala Ser Phe Val Xaa Tyr Ile Val His Gln Ser Ala Ile Arg Ile 
        35                  40                  45              


Ser Arg Lys Gly Arg His Xaa Leu Leu Asn Phe Cys Phe His Ala Ala 
    50                  55                  60                  


Leu Xaa Phe Xaa Val Phe Ala Gly Gly Ile Asn Arg Xaa Lys Tyr Pro 
65                  70                  75                  80  


Ile Leu Cys Gln Ala Val Gly Ile Val Leu His Tyr Ser Xaa Leu Ser 
                85                  90                  95      


Xaa Met Leu Trp Ile Gly Val Xaa Ala Arg Asn Ile Tyr Lys Gln Val 
            100                 105                 110         


Xaa Lys Lys Ala Pro Leu Cys Leu Asp Xaa Asp Gln Pro Pro Tyr Pro 
        115                 120                 125             


Arg Gln Pro Leu Leu Arg Phe Tyr Leu Val Ser Gly Gly Val Pro Phe 
    130                 135                 140                 


Ile Ile Cys Gly Val Xaa Ala Ala Xaa Asn Ile Arg Asn Tyr Gly Xaa 
145                 150                 155                 160 


Glu Asp Glu Asp Xaa Ala Tyr Cys Trp Met Ala Trp Glu Pro Ser Leu 
                165                 170                 175     


Gly Ala Phe Tyr Gly Pro Ala Ala Ile Ile Xaa Leu Val Xaa Cys Val 
            180                 185                 190         


Tyr Phe Leu Gly Xaa Tyr Val Gln Leu Arg Arg His Pro Gly Arg Arg 
        195                 200                 205             


Tyr Glu Leu Arg Xaa Gln Pro Glu Glu Gln Arg Arg Leu Ala Xaa Pro 
    210                 215                 220                 


Glu Gly Gly Arg Gly Ile Arg Pro Gly Xaa Pro Pro Ala His Asp Ala 
225                 230                 235                 240 


Pro Gly Ala Ser Val Leu Gln Asn Glu His Ser Phe Gln Ala Gln Leu 
                245                 250                 255     


Arg Ala Ala Ala Phe Xaa Leu Phe Leu Phe Xaa Ala Xaa Trp Ala Phe 
            260                 265                 270         


Gly Ala Leu Ala Val Ser Gln Gly His Phe Leu Asp Met Val Phe Ser 
        275                 280                 285             


Cys Leu Tyr Gly Ala Phe Cys Val Xaa Leu Gly Leu Phe Val Leu Ile 
    290                 295                 300                 


His His Cys Ala Lys Arg Glu Asp Val Trp Gln Cys Trp Trp Ala Cys 
305                 310                 315                 320 


Cys Pro Pro Arg Lys Asp Ala His Pro Ala Leu Asp Ala Asn Gly Ala 
                325                 330                 335     


Ala Leu Gly Arg Ala Ala Cys Leu His Ser Pro Gly Leu Gly Gln Pro 
            340                 345                 350         


Arg Gly Phe Ala His Pro Pro Gly Pro Cys Lys Met Xaa Asn Leu Gln 
        355                 360                 365             


Ala Ala Gln Gly His Ala Ser Cys Leu Ser Pro Ala Xaa Pro Cys Cys 
    370                 375                 380                 


Ala Lys Met His Cys Glu Pro Leu Xaa Ala Asp Glu Ala His Val His 
385                 390                 395                 400 


Leu Gln Glu Glu Gly Ala Phe Gly His Asp Pro His Leu His Gly Cys 
                405                 410                 415     


Leu Gln Gly Arg Xaa Lys Pro Pro Tyr Phe Ser Arg His Pro Ala Glu 
            420                 425                 430         


Glu Pro Glu Tyr Ala Tyr His Ile Pro Ser Ser Leu Asp Gly Ser Pro 
        435                 440                 445             


Arg Ser Ser Arg Xaa Asp Ser Pro Pro Ser Ser Leu Asp Gly Pro Ala 
    450                 455                 460                 


Gly Xaa His Xaa Leu Ala Cys Cys Xaa Gln Gly Asp Pro Phe Pro Met 
465                 470                 475                 480 


Val Xaa Gln Pro Glu Gly Ser Asp Gly Ser Pro Ala Leu Tyr Ser Cys 
                485                 490                 495     


Pro Xaa Gln Pro Gly Arg Glu Ala Ala Leu Gly Pro Gly His Leu Glu 
            500                 505                 510         


Met Leu Arg Arg Xaa Gln Ser Leu Pro Phe Gly Gly Pro Ser Gln Asn 
        515                 520                 525             


Gly Leu Pro Lys Gly Lys Leu Leu Glu Gly Leu Pro Phe Gly Xaa Asp 
    530                 535                 540                 


Gly Xaa Gly Asn Ile Arg Xaa Gly Pro Trp Lys Asn Glu Xaa Xaa Val 
545                 550                 555                 560 


<210> 1604
<211> 463
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(462)
<223> Selenocysteine

<400> 1604
Met Leu Trp Ile Gly Val Xaa Ala Arg Asn Ile Tyr Lys Gln Val Xaa 
1               5                   10                  15      


Lys Lys Ala Pro Leu Cys Leu Asp Xaa Asp Gln Pro Pro Tyr Pro Arg 
            20                  25                  30          


Gln Pro Leu Leu Arg Phe Tyr Leu Val Ser Gly Gly Val Pro Phe Ile 
        35                  40                  45              


Ile Cys Gly Val Xaa Ala Ala Xaa Asn Ile Arg Asn Tyr Gly Xaa Glu 
    50                  55                  60                  


Asp Glu Asp Xaa Ala Tyr Cys Trp Met Ala Trp Glu Pro Ser Leu Gly 
65                  70                  75                  80  


Ala Phe Tyr Gly Pro Ala Ala Ile Ile Xaa Leu Val Xaa Cys Val Tyr 
                85                  90                  95      


Phe Leu Gly Xaa Tyr Val Gln Leu Arg Arg His Pro Gly Arg Arg Tyr 
            100                 105                 110         


Glu Leu Arg Xaa Gln Pro Glu Glu Gln Arg Arg Leu Ala Xaa Pro Glu 
        115                 120                 125             


Gly Gly Arg Gly Ile Arg Pro Gly Xaa Pro Pro Ala His Asp Ala Pro 
    130                 135                 140                 


Gly Ala Ser Val Leu Gln Asn Glu His Ser Phe Gln Ala Gln Leu Arg 
145                 150                 155                 160 


Ala Ala Ala Phe Xaa Leu Phe Leu Phe Xaa Ala Xaa Trp Ala Phe Gly 
                165                 170                 175     


Ala Leu Ala Val Ser Gln Gly His Phe Leu Asp Met Val Phe Ser Cys 
            180                 185                 190         


Leu Tyr Gly Ala Phe Cys Val Xaa Leu Gly Leu Phe Val Leu Ile His 
        195                 200                 205             


His Cys Ala Lys Arg Glu Asp Val Trp Gln Cys Trp Trp Ala Cys Cys 
    210                 215                 220                 


Pro Pro Arg Lys Asp Ala His Pro Ala Leu Asp Ala Asn Gly Ala Ala 
225                 230                 235                 240 


Leu Gly Arg Ala Ala Cys Leu His Ser Pro Gly Leu Gly Gln Pro Arg 
                245                 250                 255     


Gly Phe Ala His Pro Pro Gly Pro Cys Lys Met Xaa Asn Leu Gln Ala 
            260                 265                 270         


Ala Gln Gly His Ala Ser Cys Leu Ser Pro Ala Xaa Pro Cys Cys Ala 
        275                 280                 285             


Lys Met His Cys Glu Pro Leu Xaa Ala Asp Glu Ala His Val His Leu 
    290                 295                 300                 


Gln Glu Glu Gly Ala Phe Gly His Asp Pro His Leu His Gly Cys Leu 
305                 310                 315                 320 


Gln Gly Arg Xaa Lys Pro Pro Tyr Phe Ser Arg His Pro Ala Glu Glu 
                325                 330                 335     


Pro Glu Tyr Ala Tyr His Ile Pro Ser Ser Leu Asp Gly Ser Pro Arg 
            340                 345                 350         


Ser Ser Arg Xaa Asp Ser Pro Pro Ser Ser Leu Asp Gly Pro Ala Gly 
        355                 360                 365             


Xaa His Xaa Leu Ala Cys Cys Xaa Gln Gly Asp Pro Phe Pro Met Val 
    370                 375                 380                 


Xaa Gln Pro Glu Gly Ser Asp Gly Ser Pro Ala Leu Tyr Ser Cys Pro 
385                 390                 395                 400 


Xaa Gln Pro Gly Arg Glu Ala Ala Leu Gly Pro Gly His Leu Glu Met 
                405                 410                 415     


Leu Arg Arg Xaa Gln Ser Leu Pro Phe Gly Gly Pro Ser Gln Asn Gly 
            420                 425                 430         


Leu Pro Lys Gly Lys Leu Leu Glu Gly Leu Pro Phe Gly Xaa Asp Gly 
        435                 440                 445             


Xaa Gly Asn Ile Arg Xaa Gly Pro Trp Lys Asn Glu Xaa Xaa Val 
    450                 455                 460             


<210> 1605
<211> 1279
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (873)..(873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1187)..(1187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1262)..(1262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1270)..(1270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1277)..(1278)
<223> Selenocysteine

<400> 1605
Met Arg Gly His Gly Asn His Ser Arg Leu Lys Ser Arg Cys Ala Ser 
1               5                   10                  15      


Leu Gly Asn Val His His His Gln Ala Gln Met Ala His Gly Ala His 
            20                  25                  30          


Cys Arg Gly Gly Arg Xaa Pro Gln Ser Pro Asp Ser Arg Gly Pro Xaa 
        35                  40                  45              


Ala Gly Gly His Xaa Arg Gly Arg Trp Xaa Tyr Arg Pro Ile Glu Ala 
    50                  55                  60                  


Leu Ile Asn Val Ser Phe Pro Gly Ala Lys Gly Gly Arg Xaa Ala Glu 
65                  70                  75                  80  


Gly Glu Pro Ser Trp Ala Trp Val Phe Arg Ser Gly Tyr Leu Gln Arg 
                85                  90                  95      


Gln Ala Leu Pro Gly Leu Pro Val Ser Xaa Arg Val Ala Ala Cys Trp 
            100                 105                 110         


Trp Gln His His Pro Gly Arg Asp Ser Gly Phe Leu Gly Pro Gly Phe 
        115                 120                 125             


Ile Asp Leu Leu Arg Glu Glu Pro Ser Gly Arg Ala Asp Gly Lys Ala 
    130                 135                 140                 


Ala Ala Gln Lys Xaa Gly Arg Leu Tyr Leu Phe Pro Xaa Phe Leu Gly 
145                 150                 155                 160 


Asn Lys Leu Pro Glu Ala Ala Asp Ser Phe Gly Glu Ile Ala Ser Gly 
                165                 170                 175     


Asn Ser Val Ile Phe Xaa Ser Val Leu Gln Ser Ser His Pro Pro Gly 
            180                 185                 190         


Xaa Pro Pro Pro Ser Ala Arg Lys Pro Ser Pro Gly Ala Ala Met Leu 
        195                 200                 205             


Val Cys Glu Glu Xaa Leu Glu Leu Gly Ala Gln Gly Cys Trp Gly Ser 
    210                 215                 220                 


Xaa Ser Pro Arg Gly Gln Ala Val Ser Leu Val Gly Gly Pro Xaa Ala 
225                 230                 235                 240 


Gly Gly Ser Arg Leu Gly Gly Ala Gly Cys Xaa Met Gly Leu Leu Met 
                245                 250                 255     


Ala Leu Gln Ala Arg Arg Pro Arg Asp Gly Xaa Trp Ala Asp Pro Arg 
            260                 265                 270         


Arg Cys Ser Arg Ala Val Glu Gly Ser Gly Leu Xaa Arg Ala Ala Leu 
        275                 280                 285             


Val Ser Pro Gly Pro Ser Gly Val Glu Glu Asp Xaa Arg Arg Glu Gly 
    290                 295                 300                 


Cys Val Leu Val Gly Ser Trp Arg Ser Ser Xaa His Arg Ser Arg Val 
305                 310                 315                 320 


Leu Ile Ile Asn Xaa Pro Ser Gly Arg Xaa Pro Trp Ser Gln Gly Ser 
                325                 330                 335     


Leu Gly Ser Xaa Gly Arg Tyr Asn Gln Xaa Arg Ala Pro Gly Ser Gln 
            340                 345                 350         


Gln Gln Gly Leu Cys Ser Asp Ala Ala Leu His Glu Asp Phe Val Pro 
        355                 360                 365             


Glu Pro Xaa Pro Ala Phe Phe Gln Tyr Pro Pro Gln Ala Phe Ser Lys 
    370                 375                 380                 


Xaa Lys Val Arg Asp Leu Gly Arg Gly Gly Leu Tyr Ala Phe Ser Lys 
385                 390                 395                 400 


Glu Glu Lys Val Ser Glu Ala Gln Arg Val Glu Ala Tyr Glu Xaa His 
                405                 410                 415     


Gly Leu Gly Leu Ser Xaa Gly Arg Gln Asn Pro Val Pro Ser Pro Cys 
            420                 425                 430         


Lys Pro Gly Cys Val Cys Gln Gly Leu Ala Leu Asp Ala Glu Ala Trp 
        435                 440                 445             


Pro Arg His Pro Gly Arg Arg Pro Cys Ala Ala Lys Glu Ala Cys Leu 
    450                 455                 460                 


Gly Pro Pro Gly Cys Ser Gly Glu Leu Ser Leu Pro Glu Glu Glu Gly 
465                 470                 475                 480 


Ile Ala Pro Gly Ala Ala Xaa Ala Ala Pro Ala Trp Val Pro His Gly 
                485                 490                 495     


Arg Val Ser Arg Phe Leu Xaa Val Lys Leu Phe Xaa Tyr Val Xaa Met 
            500                 505                 510         


Tyr Gln Cys Lys Gln Glu Arg Ile Leu Arg Leu Cys Ile Ser Gly Glu 
        515                 520                 525             


Ser Gly Arg Tyr Val Arg Arg Ser Arg Phe Arg Asn Phe Ala Ala Leu 
    530                 535                 540                 


Met Val Ser Xaa Gly Val Pro Gly Val Leu Gln Leu Gly Ala Arg Pro 
545                 550                 555                 560 


Leu Arg Gly Gly Gly His Pro Tyr Gly Asp Ser Gln Ala Gly Lys Val 
                565                 570                 575     


Val Glu Trp Arg Ala Gly Asp Arg Ala Ser Gly Leu Ser Ala Gly Glu 
            580                 585                 590         


Arg Arg Phe Leu Ser Gln Ser Glu Leu Gln Xaa Trp Pro Arg Xaa Pro 
        595                 600                 605             


His Cys Val Gly Lys Lys Val Pro Gln Pro Val Gly Ala Ala Asp Leu 
    610                 615                 620                 


Ala Pro Asp Xaa Ser Leu Cys Arg Lys Glu Gly Ser Ser Ala Ser Arg 
625                 630                 635                 640 


Ser Cys Arg Pro Gly Pro Gly His Leu Xaa Arg Arg Glu Glu Asp Ser 
                645                 650                 655     


Phe Arg Gln Leu Ala Phe Pro Arg Phe Glu Glu Val Xaa Phe Pro Pro 
            660                 665                 670         


Leu Xaa Ala Ala Glu Arg Ala Pro Ser Val His Gly Gly His Ser Leu 
        675                 680                 685             


Ala Ser Gln Gly Leu Val Leu Ala Gly Arg Xaa Arg Ser Val Ala Ser 
    690                 695                 700                 


Gly Gly Lys Gln Glu Leu Ser Gly Pro Leu Ala Ala Cys Ile Pro Xaa 
705                 710                 715                 720 


Gln Asp Leu Lys Xaa Val Leu Ser Leu Pro Arg Tyr Pro Gly Glu Phe 
                725                 730                 735     


Leu His Pro Val Val Tyr Ala Cys Xaa Ala Val Met Leu Leu Cys Leu 
            740                 745                 750         


Leu Ala Ser Phe Val Xaa Tyr Ile Val His Gln Ser Ala Ile Arg Ile 
        755                 760                 765             


Ser Arg Lys Gly Arg His Xaa Leu Leu Asn Phe Cys Phe His Ala Ala 
    770                 775                 780                 


Leu Xaa Phe Xaa Val Phe Ala Gly Gly Ile Asn Arg Xaa Lys Tyr Pro 
785                 790                 795                 800 


Ile Leu Cys Gln Ala Val Gly Ile Val Leu His Tyr Ser Xaa Leu Ser 
                805                 810                 815     


Xaa Met Leu Trp Ile Gly Val Xaa Ala Arg Asn Ile Tyr Lys Gln Val 
            820                 825                 830         


Xaa Lys Lys Ala Pro Leu Cys Leu Asp Xaa Asp Gln Pro Pro Tyr Pro 
        835                 840                 845             


Arg Gln Pro Leu Leu Arg Phe Tyr Leu Val Ser Gly Gly Val Pro Phe 
    850                 855                 860                 


Ile Ile Cys Gly Val Xaa Ala Ala Xaa Asn Ile Arg Asn Tyr Gly Xaa 
865                 870                 875                 880 


Glu Asp Glu Asp Xaa Ala Cys Trp Met Ala Trp Glu Pro Ser Leu Gly 
                885                 890                 895     


Ala Phe Tyr Gly Pro Ala Ala Ile Ile Xaa Leu Val Xaa Cys Val Tyr 
            900                 905                 910         


Phe Leu Gly Xaa Tyr Val Gln Leu Arg Arg His Pro Gly Arg Arg Tyr 
        915                 920                 925             


Glu Leu Arg Xaa Gln Pro Glu Glu Gln Arg Arg Leu Ala Xaa Pro Glu 
    930                 935                 940                 


Gly Gly Arg Gly Ile Arg Pro Gly Xaa Pro Pro Ala His Asp Ala Pro 
945                 950                 955                 960 


Gly Ala Ser Val Leu Gln Asn Glu His Ser Phe Gln Ala Gln Leu Arg 
                965                 970                 975     


Ala Ala Ala Phe Xaa Leu Phe Leu Phe Xaa Ala Xaa Trp Ala Phe Gly 
            980                 985                 990         


Ala Leu Ala Val Ser Gln Gly His  Phe Leu Asp Met Val  Phe Ser Cys 
        995                 1000                 1005             


Leu Tyr  Gly Ala Phe Cys Val  Xaa Leu Gly Leu Phe  Val Leu Ile 
    1010                 1015                 1020             


His His  Cys Ala Lys Arg Glu  Asp Val Trp Gln Cys  Trp Trp Ala 
    1025                 1030                 1035             


Cys Cys  Pro Pro Arg Lys Asp  Ala His Pro Ala Leu  Asp Ala Asn 
    1040                 1045                 1050             


Gly Ala  Ala Leu Gly Arg Ala  Ala Cys Leu His Ser  Pro Gly Leu 
    1055                 1060                 1065             


Gly Gln  Pro Arg Gly Phe Ala  His Pro Pro Gly Pro  Cys Lys Met 
    1070                 1075                 1080             


Xaa Asn  Leu Gln Ala Ala Gln  Gly His Ala Ser Cys  Leu Ser Pro 
    1085                 1090                 1095             


Ala Xaa  Pro Cys Cys Ala Lys  Met His Cys Glu Pro  Leu Xaa Ala 
    1100                 1105                 1110             


Asp Glu  Ala His Val His Leu  Gln Glu Glu Gly Ala  Phe Gly His 
    1115                 1120                 1125             


Asp Pro  His Leu His Gly Cys  Leu Gln Gly Arg Xaa  Lys Pro Pro 
    1130                 1135                 1140             


Tyr Phe  Ser Arg His Pro Ala  Glu Glu Pro Glu Tyr  Ala Tyr His 
    1145                 1150                 1155             


Ile Pro  Ser Ser Leu Asp Gly  Ser Pro Arg Ser Ser  Arg Xaa Asp 
    1160                 1165                 1170             


Ser Pro  Pro Ser Ser Leu Asp  Gly Pro Ala Gly Xaa  His Xaa Leu 
    1175                 1180                 1185             


Ala Cys  Cys Xaa Gln Gly Asp  Pro Phe Pro Met Val  Xaa Gln Pro 
    1190                 1195                 1200             


Glu Gly  Ser Asp Gly Ser Pro  Ala Leu Tyr Ser Cys  Pro Xaa Gln 
    1205                 1210                 1215             


Pro Gly  Arg Glu Ala Ala Leu  Gly Pro Gly His Leu  Glu Met Leu 
    1220                 1225                 1230             


Arg Arg  Xaa Gln Ser Leu Pro  Phe Gly Gly Pro Ser  Gln Asn Gly 
    1235                 1240                 1245             


Leu Pro  Lys Gly Lys Leu Leu  Glu Gly Leu Pro Phe  Gly Xaa Asp 
    1250                 1255                 1260             


Gly Xaa  Gly Asn Ile Arg Xaa  Gly Pro Trp Lys Asn  Glu Xaa Xaa 
    1265                 1270                 1275             


Val 
    


<210> 1606
<211> 1121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1120)
<223> Selenocysteine

<400> 1606
Met Gly Ala Gly Gly Arg Arg Met Arg Gly Ala Pro Ala Arg Leu Leu 
1               5                   10                  15      


Leu Pro Leu Leu Pro Trp Leu Leu Leu Leu Leu Ala Pro Glu Ala Arg 
            20                  25                  30          


Gly Ala Pro Gly Cys Pro Leu Ser Ile Arg Ser Cys Lys Cys Ser Gly 
        35                  40                  45              


Glu Arg Pro Lys Gly Leu Ser Gly Gly Val Pro Gly Pro Ala Arg Arg 
    50                  55                  60                  


Arg Val Val Cys Ser Gly Gly Asp Leu Pro Glu Pro Pro Glu Pro Gly 
65                  70                  75                  80  


Leu Leu Pro Asn Gly Xaa Val Xaa Leu Leu Leu Ser Asn Asn Lys Ile 
                85                  90                  95      


Xaa Gly Leu Arg Asn Gly Ser Phe Leu Gly Leu Ser Leu Leu Glu Lys 
            100                 105                 110         


Leu Asp Leu Arg Asn Asn Ile Ile Ser Xaa Val Gln Pro Gly Ala Phe 
        115                 120                 125             


Leu Gly Leu Gly Glu Leu Lys Arg Leu Asp Leu Ser Asn Asn Arg Ile 
    130                 135                 140                 


Gly Cys Leu Xaa Ser Glu Xaa Phe Gln Gly Leu Pro Arg Leu Leu Arg 
145                 150                 155                 160 


Leu Asn Ile Ser Gly Asn Ile Phe Ser Ser Leu Gln Pro Gly Val Phe 
                165                 170                 175     


Asp Glu Leu Pro Ala Leu Lys Val Val Asp Leu Gly Xaa Glu Phe Leu 
            180                 185                 190         


Xaa Cys Asp Cys His Leu Arg Trp Leu Leu Pro Trp Ala Gln Asn Arg 
        195                 200                 205             


Ser Leu Gln Leu Ser Glu His Xaa Leu Cys Ala Tyr Pro Ser Ala Leu 
    210                 215                 220                 


His Ala Gln Ala Leu Gly Ser Leu Gln Glu Ala Gln Leu Cys Cys Glu 
225                 230                 235                 240 


Gly Ala Leu Glu Leu His Xaa His His Leu Ile Pro Ser Leu Arg Gln 
                245                 250                 255     


Val Val Phe Gln Gly Asp Arg Leu Pro Phe Gln Cys Ser Ala Ser Tyr 
            260                 265                 270         


Leu Gly Asn Asp Xaa Arg Ile Arg Trp Tyr His Asn Arg Ala Pro Val 
        275                 280                 285             


Glu Gly Asp Glu Gln Ala Gly Ile Leu Leu Ala Glu Ser Leu Ile His 
    290                 295                 300                 


Asp Cys Xaa Phe Ile Xaa Ser Glu Leu Xaa Leu Ser His Ile Gly Val 
305                 310                 315                 320 


Trp Ala Ser Gly Glu Trp Glu Cys Xaa Val Ser Met Ala Gln Gly Asn 
                325                 330                 335     


Ala Ser Lys Lys Val Glu Ile Val Val Leu Glu Xaa Ser Ala Ser Tyr 
            340                 345                 350         


Cys Pro Ala Glu Arg Val Ala Asn Asn Arg Gly Asp Phe Arg Trp Pro 
        355                 360                 365             


Arg Xaa Leu Ala Gly Ile Xaa Ala Tyr Gln Ser Cys Leu Gln Tyr Pro 
    370                 375                 380                 


Phe Xaa Ser Val Pro Leu Gly Gly Gly Ala Pro Gly Xaa Arg Ala Ser 
385                 390                 395                 400 


Arg Arg Cys Asp Arg Ala Gly Arg Trp Glu Pro Gly Asp Tyr Ser His 
                405                 410                 415     


Cys Leu Tyr Xaa Asn Asp Ile Xaa Arg Val Leu Tyr Xaa Phe Val Leu 
            420                 425                 430         


Met Pro Ile Asn Ala Ser Asn Ala Leu Xaa Leu Ala His Gln Leu Arg 
        435                 440                 445             


Val Tyr Xaa Ala Glu Ala Ala Ser Phe Ser Asp Met Met Asp Val Val 
    450                 455                 460                 


Tyr Val Ala Gln Met Ile Gln Lys Phe Leu Gly Tyr Val Asp Gln Ile 
465                 470                 475                 480 


Lys Glu Leu Val Glu Val Met Val Asp Met Ala Ser Asn Leu Met Leu 
                485                 490                 495     


Val Asp Glu His Leu Leu Trp Leu Ala Gln Arg Glu Asp Lys Ala Cys 
            500                 505                 510         


Ser Arg Ile Val Gly Ala Leu Glu Arg Ile Gly Gly Ala Ala Leu Ser 
        515                 520                 525             


Pro His Ala Gln His Ile Ser Val Glu Leu Ser Ala Phe Pro Arg Glu 
    530                 535                 540                 


Val Gly Gly Ala Gly Ala Gly Leu His Pro Val Val Tyr Pro Cys Xaa 
545                 550                 555                 560 


Ala Leu Leu Leu Leu Cys Leu Phe Ala Xaa Ile Ile Xaa Tyr Ile Leu 
                565                 570                 575     


Asn His Ser Ser Ile Arg Val Ser Arg Lys Gly Trp His Met Leu Leu 
            580                 585                 590         


Asn Leu Cys Phe His Ile Ala Met Xaa Ser Ala Val Phe Ala Gly Gly 
        595                 600                 605             


Ile Xaa Leu Xaa Asn Tyr Gln Met Val Cys Gln Ala Val Gly Ile Xaa 
    610                 615                 620                 


Leu His Tyr Ser Ser Leu Ser Xaa Leu Leu Trp Met Gly Val Lys Ala 
625                 630                 635                 640 


Arg Val Leu His Lys Glu Leu Xaa Trp Arg Ala Pro Pro Pro Gln Glu 
                645                 650                 655     


Gly Asp Pro Ala Leu Pro Xaa Pro Ser Pro Met Leu Arg Phe Tyr Leu 
            660                 665                 670         


Ile Ala Gly Gly Ile Pro Leu Ile Ile Cys Gly Ile Xaa Ala Ala Val 
        675                 680                 685             


Asn Ile His Asn Tyr Arg Asp His Ser Pro Tyr Cys Trp Leu Val Trp 
    690                 695                 700                 


Arg Pro Ser Leu Gly Ala Phe Tyr Ile Pro Val Ala Leu Ile Leu Leu 
705                 710                 715                 720 


Ile Xaa Trp Ile Tyr Phe Leu Cys Ala Gly Leu Arg Leu Arg Gly Pro 
                725                 730                 735     


Leu Ala Gln Asn Pro Lys Ala Gly Asn Ser Arg Ala Ser Leu Glu Ala 
            740                 745                 750         


Gly Glu Glu Leu Arg Gly Ser Xaa Arg Leu Arg Gly Ser Gly Pro Leu 
        755                 760                 765             


Leu Ser Asp Ser Gly Ser Leu Leu Ala Xaa Gly Ser Ala Arg Val Gly 
    770                 775                 780                 


Xaa Pro Gly Pro Pro Glu Asp Gly Asp Ser Leu Tyr Ser Pro Gly Val 
785                 790                 795                 800 


Gln Leu Gly Ala Leu Val Xaa Xaa His Phe Leu Tyr Leu Ala Met Trp 
                805                 810                 815     


Ala Cys Gly Ala Leu Ala Val Ser Gln Arg Trp Leu Pro Arg Val Val 
            820                 825                 830         


Cys Ser Cys Leu Tyr Gly Val Ala Ala Ser Ala Leu Gly Leu Phe Val 
        835                 840                 845             


Phe Xaa His His Cys Ala Arg Arg Arg Asp Val Arg Ala Ser Trp Arg 
    850                 855                 860                 


Ala Cys Cys Pro Pro Ala Ser Pro Ala Ala Pro His Ala Pro Pro Arg 
865                 870                 875                 880 


Ala Leu Pro Ala Ala Ala Glu Asp Gly Ser Pro Val Phe Gly Glu Gly 
                885                 890                 895     


Pro Pro Ser Leu Lys Ser Ser Pro Ser Gly Ser Ser Gly His Pro Leu 
            900                 905                 910         


Ala Leu Gly Pro Cys Lys Leu Xaa Asn Leu Gln Leu Ala Gln Ser Gln 
        915                 920                 925             


Val Cys Glu Ala Gly Ala Ala Ala Gly Gly Glu Gly Glu Pro Glu Pro 
    930                 935                 940                 


Ala Gly Xaa Arg Gly Asn Leu Ala His Arg His Pro Asn Asn Val His 
945                 950                 955                 960 


His Gly Arg Arg Ala His Lys Ser Arg Ala Lys Gly His Arg Ala Gly 
                965                 970                 975     


Glu Ala Cys Gly Lys Asn Arg Leu Lys Ala Leu Arg Gly Gly Ala Ala 
            980                 985                 990         


Gly Ala Leu Glu Leu Leu Ser Ser  Glu Ser Gly Ser Leu  His Asn Ser 
        995                 1000                 1005             


Pro Xaa  Asp Ser Tyr Leu Gly  Ser Ser Arg Asn Ser  Pro Gly Ala 
    1010                 1015                 1020             


Gly Leu  Gln Leu Glu Gly Glu  Pro Met Leu Xaa Pro  Ser Glu Gly 
    1025                 1030                 1035             


Ser Asp  Xaa Ser Ala Ala Pro  Leu Ser Glu Ala Gly  Arg Ala Gly 
    1040                 1045                 1050             


Gln Arg  Arg Ser Ala Ser Arg  Asp Ser Leu Lys Gly  Gly Gly Ala 
    1055                 1060                 1065             


Leu Glu  Lys Glu Ser His Arg  Arg Ser Tyr Pro Leu  Asn Ala Ala 
    1070                 1075                 1080             


Ser Leu  Asn Gly Ala Pro Lys  Gly Gly Lys Tyr Asp  Asp Val Xaa 
    1085                 1090                 1095             


Leu Met  Gly Ala Glu Val Ala  Ser Gly Gly Cys Met  Lys Xaa Gly 
    1100                 1105                 1110             


Leu Trp  Lys Ser Glu Xaa Xaa  Val 
    1115                 1120     


<210> 1607
<211> 1338
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1315)..(1315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1337)
<223> Selenocysteine

<400> 1607
Met Gly Ala Gly Gly Arg Arg Met Arg Gly Ala Pro Ala Arg Leu Leu 
1               5                   10                  15      


Leu Pro Leu Leu Pro Trp Leu Leu Leu Leu Leu Ala Pro Glu Ala Arg 
            20                  25                  30          


Gly Ala Pro Gly Cys Pro Leu Ser Ile Arg Ser Cys Lys Cys Ser Gly 
        35                  40                  45              


Glu Arg Pro Lys Gly Leu Ser Gly Gly Val Pro Gly Pro Ala Arg Arg 
    50                  55                  60                  


Arg Val Val Cys Ser Gly Gly Asp Leu Pro Glu Pro Pro Glu Pro Gly 
65                  70                  75                  80  


Leu Leu Pro Asn Gly Xaa Val Xaa Leu Leu Leu Ser Asn Asn Lys Ile 
                85                  90                  95      


Xaa Gly Leu Arg Asn Gly Ser Phe Leu Gly Leu Ser Leu Leu Glu Lys 
            100                 105                 110         


Leu Asp Leu Arg Asn Asn Ile Ile Ser Xaa Val Gln Pro Gly Ala Phe 
        115                 120                 125             


Leu Gly Leu Gly Glu Leu Lys Arg Leu Asp Leu Ser Asn Asn Arg Ile 
    130                 135                 140                 


Gly Cys Leu Xaa Ser Glu Xaa Phe Gln Gly Leu Pro Arg Leu Leu Arg 
145                 150                 155                 160 


Leu Asn Ile Ser Gly Asn Ile Phe Ser Ser Leu Gln Pro Gly Val Phe 
                165                 170                 175     


Asp Glu Leu Pro Ala Leu Lys Val Val Asp Leu Gly Xaa Glu Phe Leu 
            180                 185                 190         


Xaa Cys Asp Cys His Leu Arg Trp Leu Leu Pro Trp Ala Gln Asn Arg 
        195                 200                 205             


Ser Leu Gln Leu Ser Glu His Xaa Leu Cys Ala Tyr Pro Ser Ala Leu 
    210                 215                 220                 


His Ala Gln Ala Leu Gly Ser Leu Gln Glu Ala Gln Leu Cys Cys Glu 
225                 230                 235                 240 


Gly Ala Leu Glu Leu His Xaa His His Leu Ile Pro Ser Leu Arg Gln 
                245                 250                 255     


Val Val Phe Gln Gly Asp Arg Leu Pro Phe Gln Cys Ser Ala Ser Tyr 
            260                 265                 270         


Leu Gly Asn Asp Xaa Arg Ile Arg Trp Tyr His Asn Arg Ala Pro Val 
        275                 280                 285             


Glu Gly Asp Glu Gln Ala Gly Ile Leu Leu Ala Glu Ser Leu Ile His 
    290                 295                 300                 


Asp Cys Xaa Phe Ile Xaa Ser Glu Leu Xaa Leu Ser His Ile Gly Val 
305                 310                 315                 320 


Trp Ala Ser Gly Glu Trp Glu Cys Xaa Val Ser Met Ala Gln Gly Asn 
                325                 330                 335     


Ala Ser Lys Lys Val Glu Ile Val Val Leu Glu Xaa Ser Ala Ser Tyr 
            340                 345                 350         


Cys Pro Ala Glu Arg Val Ala Asn Asn Arg Gly Asp Phe Arg Trp Pro 
        355                 360                 365             


Arg Xaa Leu Ala Gly Ile Xaa Ala Tyr Gln Ser Cys Leu Gln Tyr Pro 
    370                 375                 380                 


Phe Xaa Ser Val Pro Leu Gly Gly Gly Ala Pro Gly Xaa Arg Ala Ser 
385                 390                 395                 400 


Arg Arg Cys Asp Arg Ala Gly Arg Trp Glu Pro Gly Asp Tyr Ser His 
                405                 410                 415     


Cys Leu Tyr Xaa Asn Asp Ile Xaa Arg Val Leu Tyr Xaa Phe Val Leu 
            420                 425                 430         


Met Pro Ile Asn Ala Ser Asn Ala Leu Xaa Leu Ala His Gln Leu Arg 
        435                 440                 445             


Val Tyr Xaa Ala Glu Ala Ala Ser Phe Ser Asp Met Met Asp Val Val 
    450                 455                 460                 


Tyr Val Ala Gln Met Ile Gln Lys Phe Leu Gly Tyr Val Asp Gln Ile 
465                 470                 475                 480 


Lys Glu Leu Val Glu Val Met Val Asp Met Ala Ser Asn Leu Met Leu 
                485                 490                 495     


Val Asp Glu His Leu Leu Trp Leu Ala Gln Arg Glu Asp Lys Ala Cys 
            500                 505                 510         


Ser Arg Ile Val Gly Ala Leu Glu Arg Ile Gly Gly Ala Ala Leu Ser 
        515                 520                 525             


Pro His Ala Gln His Ile Ser Val Asn Ala Arg Asn Val Ala Leu Glu 
    530                 535                 540                 


Ala Tyr Leu Ile Lys Pro His Ser Tyr Val Gly Leu Xaa Cys Xaa Ala 
545                 550                 555                 560 


Phe Gln Arg Arg Glu Gly Gly Val Pro Gly Xaa Arg Pro Gly Ser Pro 
                565                 570                 575     


Gly Gln Asn Pro Pro Pro Glu Pro Glu Pro Pro Ala Asp Gln Gln Leu 
            580                 585                 590         


Arg Phe Arg Cys Xaa Xaa Gly Arg Pro Asn Val Ser Leu Ser Ser Phe 
        595                 600                 605             


His Ile Lys Asn Ser Val Ala Leu Ala Ser Ile Gln Leu Pro Pro Ser 
    610                 615                 620                 


Leu Phe Ser Ser Leu Pro Ala Ala Leu Ala Pro Pro Val Pro Pro Asp 
625                 630                 635                 640 


Cys Xaa Leu Gln Leu Leu Val Phe Arg Asn Gly Arg Leu Phe His Ser 
                645                 650                 655     


His Ser Asn Xaa Ser Arg Pro Gly Ala Ala Gly Pro Gly Lys Arg Arg 
            660                 665                 670         


Gly Val Ala Xaa Pro Val Ile Phe Ala Gly Xaa Ser Gly Cys Gly Val 
        675                 680                 685             


Gly Asn Leu Xaa Glu Pro Val Ala Val Ser Leu Arg His Trp Ala Glu 
    690                 695                 700                 


Gly Ala Glu Pro Val Ala Ala Trp Trp Ser Gln Glu Gly Pro Gly Glu 
705                 710                 715                 720 


Ala Gly Gly Trp Xaa Ser Glu Gly Cys Gln Leu Arg Ser Ser Gln Pro 
                725                 730                 735     


Asn Val Ser Ala Leu His Cys Gln His Leu Gly Asn Val Ala Val Leu 
            740                 745                 750         


Met Glu Leu Ser Ala Phe Pro Arg Glu Val Gly Gly Ala Gly Ala Gly 
        755                 760                 765             


Leu His Pro Val Val Tyr Pro Cys Xaa Ala Leu Leu Leu Leu Cys Leu 
    770                 775                 780                 


Phe Ala Xaa Ile Ile Xaa Tyr Ile Leu Asn His Ser Ser Ile Arg Val 
785                 790                 795                 800 


Ser Arg Lys Gly Trp His Met Leu Leu Asn Leu Cys Phe His Ile Ala 
                805                 810                 815     


Met Xaa Ser Ala Val Phe Ala Gly Gly Ile Xaa Leu Xaa Asn Tyr Gln 
            820                 825                 830         


Met Val Cys Gln Ala Val Gly Ile Xaa Leu His Tyr Ser Ser Leu Ser 
        835                 840                 845             


Xaa Leu Leu Trp Met Gly Val Lys Ala Arg Val Leu His Lys Glu Leu 
    850                 855                 860                 


Xaa Trp Arg Ala Pro Pro Pro Gln Glu Gly Asp Pro Ala Leu Pro Xaa 
865                 870                 875                 880 


Pro Ser Pro Met Leu Arg Phe Tyr Leu Ile Ala Gly Gly Ile Pro Leu 
                885                 890                 895     


Ile Ile Cys Gly Ile Xaa Ala Ala Val Asn Ile His Asn Tyr Arg Asp 
            900                 905                 910         


His Ser Pro Tyr Cys Trp Leu Val Trp Arg Pro Ser Leu Gly Ala Phe 
        915                 920                 925             


Tyr Ile Pro Val Ala Leu Ile Leu Leu Ile Xaa Trp Ile Tyr Phe Leu 
    930                 935                 940                 


Cys Ala Gly Leu Arg Leu Arg Gly Pro Leu Ala Gln Asn Pro Lys Ala 
945                 950                 955                 960 


Gly Asn Ser Arg Ala Ser Leu Glu Ala Gly Glu Glu Leu Arg Gly Ser 
                965                 970                 975     


Xaa Arg Leu Arg Gly Ser Gly Pro Leu Leu Ser Asp Ser Gly Ser Leu 
            980                 985                 990         


Leu Ala Xaa Gly Ser Ala Arg Val  Gly Xaa Pro Gly Pro  Pro Glu Asp 
        995                 1000                 1005             


Gly Asp  Ser Leu Tyr Ser Pro  Gly Val Gln Leu Gly  Ala Leu Val 
    1010                 1015                 1020             


Xaa Xaa  His Phe Leu Tyr Leu  Ala Met Trp Ala Cys  Gly Ala Leu 
    1025                 1030                 1035             


Ala Val  Ser Gln Arg Trp Leu  Pro Arg Val Val Cys  Ser Cys Leu 
    1040                 1045                 1050             


Tyr Gly  Val Ala Ala Ser Ala  Leu Gly Leu Phe Val  Phe Xaa His 
    1055                 1060                 1065             


His Cys  Ala Arg Arg Arg Asp  Val Arg Ala Ser Trp  Arg Ala Cys 
    1070                 1075                 1080             


Cys Pro  Pro Ala Ser Pro Ala  Ala Pro His Ala Pro  Pro Arg Ala 
    1085                 1090                 1095             


Leu Pro  Ala Ala Ala Glu Asp  Gly Ser Pro Val Phe  Gly Glu Gly 
    1100                 1105                 1110             


Pro Pro  Ser Leu Lys Ser Ser  Pro Ser Gly Ser Ser  Gly His Pro 
    1115                 1120                 1125             


Leu Ala  Leu Gly Pro Cys Lys  Leu Xaa Asn Leu Gln  Leu Ala Gln 
    1130                 1135                 1140             


Ser Gln  Val Cys Glu Ala Gly  Ala Ala Ala Gly Gly  Glu Gly Glu 
    1145                 1150                 1155             


Pro Glu  Pro Ala Gly Xaa Arg  Gly Asn Leu Ala His  Arg His Pro 
    1160                 1165                 1170             


Asn Asn  Val His His Gly Arg  Arg Ala His Lys Ser  Arg Ala Lys 
    1175                 1180                 1185             


Gly His  Arg Ala Gly Glu Ala  Cys Gly Lys Asn Arg  Leu Lys Ala 
    1190                 1195                 1200             


Leu Arg  Gly Gly Ala Ala Gly  Ala Leu Glu Leu Leu  Ser Ser Glu 
    1205                 1210                 1215             


Ser Gly  Ser Leu His Asn Ser  Pro Xaa Asp Ser Tyr  Leu Gly Ser 
    1220                 1225                 1230             


Ser Arg  Asn Ser Pro Gly Ala  Gly Leu Gln Leu Glu  Gly Glu Pro 
    1235                 1240                 1245             


Met Leu  Xaa Pro Ser Glu Gly  Ser Asp Xaa Ser Ala  Ala Pro Leu 
    1250                 1255                 1260             


Ser Glu  Ala Gly Arg Ala Gly  Gln Arg Arg Ser Ala  Ser Arg Asp 
    1265                 1270                 1275             


Ser Leu  Lys Gly Gly Gly Ala  Leu Glu Lys Glu Ser  His Arg Arg 
    1280                 1285                 1290             


Ser Tyr  Pro Leu Asn Ala Ala  Ser Leu Asn Gly Ala  Pro Lys Gly 
    1295                 1300                 1305             


Gly Lys  Tyr Asp Asp Val Xaa  Leu Met Gly Ala Glu  Val Ala Ser 
    1310                 1315                 1320             


Gly Gly  Cys Met Lys Xaa Gly  Leu Trp Lys Ser Glu  Xaa Xaa Val 
    1325                 1330                 1335             


<210> 1608
<211> 190
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<400> 1608
Arg Ala Ala Val Gln Gly Leu Glu Pro Arg Pro Ala His Leu Ser Leu 
1               5                   10                  15      


Gly Cys Val Ala Ala Phe Leu Tyr Trp Phe Pro Arg Glu His Leu Leu 
            20                  25                  30          


His Gly Gly Lys Gly Lys Val Pro Ser Tyr Leu Gly Cys Leu Gly Leu 
        35                  40                  45              


Leu Ser Asn Asn Lys Ile Xaa Gly Leu Arg Asn Gly Ser Phe Leu Gly 
    50                  55                  60                  


Leu Ser Leu Leu Glu Lys Leu Asp Leu Arg Asn Asn Ile Ile Ser Xaa 
65                  70                  75                  80  


Val Gln Pro Gly Ala Phe Leu Gly Leu Gly Glu Leu Lys Arg Leu Asp 
                85                  90                  95      


Leu Ser Asn Asn Arg Ile Gly Cys Leu Xaa Ser Glu Xaa Phe Gln Gly 
            100                 105                 110         


Leu Pro Arg Leu Leu Arg Leu Asn Ile Ser Gly Asn Ile Phe Ser Ser 
        115                 120                 125             


Leu Gln Pro Gly Val Phe Asp Glu Leu Pro Ala Leu Lys Val Val Asp 
    130                 135                 140                 


Leu Gly Xaa Glu Phe Leu Xaa Cys Asp Cys His Leu Arg Trp Leu Leu 
145                 150                 155                 160 


Pro Trp Ala Gln Asn Arg Ser Leu Gln Leu Ser Glu His Xaa Leu Cys 
                165                 170                 175     


Ala Tyr Pro Ser Ala Leu His Ala Gln Ala Leu Gly Ser Leu 
            180                 185                 190 


<210> 1609
<211> 97
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<400> 1609
Met Ala Ser Tyr Ile Asp Gln Asp Met Gln Val Leu Trp Tyr Gln Asp 
1               5                   10                  15      


Gly Arg Ile Val Glu Xaa Asp Glu Ser Gln Gly Ile Phe Val Glu Lys 
            20                  25                  30          


Asn Met Ile His Asn Cys Ser Leu Ile Ala Ser Ala Leu Xaa Ile Ser 
        35                  40                  45              


Asn Ile Gln Ala Gly Ser Xaa Gly Asn Trp Gly Cys His Val Gln Xaa 
    50                  55                  60                  


Lys Arg Gly Asn Asn Xaa Arg Xaa Val Asp Ile Val Val Leu Glu Ser 
65                  70                  75                  80  


Ser Ala Gln Tyr Cys Pro Pro Glu Arg Val Val Asn Asn Lys Gly Asp 
                85                  90                  95      


Phe 
    


<210> 1610
<211> 616
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<400> 1610
Met Glu Pro Pro Gly Arg Arg Arg Gly Arg Ala Gln Pro Pro Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Ala Leu Leu Ala Leu Leu Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Ala Ala Leu Pro Ala Gly Cys Lys His Asp Gly Arg 
        35                  40                  45              


Pro Arg Gly Ala Gly Arg Ala Ala Gly Ala Ala Glu Gly Lys Val Val 
    50                  55                  60                  


Cys Ser Ser Leu Glu Leu Ala Gln Val Leu Pro Pro Asp Xaa Leu Pro 
65                  70                  75                  80  


Asn Arg Xaa Val Xaa Leu Ile Leu Ser Asn Asn Lys Ile Ser Glu Leu 
                85                  90                  95      


Lys Asn Gly Ser Phe Ser Gly Leu Ser Leu Leu Glu Arg Leu Asp Leu 
            100                 105                 110         


Arg Asn Asn Leu Ile Ser Ser Ile Asp Pro Gly Ala Phe Trp Gly Leu 
        115                 120                 125             


Ser Ser Leu Lys Arg Leu Asp Leu Xaa Asn Asn Arg Ile Gly Cys Leu 
    130                 135                 140                 


Asn Ala Asp Ile Phe Arg Gly Leu Xaa Asn Leu Val Arg Leu Asn Leu 
145                 150                 155                 160 


Ser Gly Asn Leu Phe Ser Ser Leu Ser Gln Gly Xaa Phe Asp Tyr Leu 
                165                 170                 175     


Ala Ser Leu Arg Ser Leu Glu Phe Gln Xaa Glu Tyr Leu Leu Cys Asp 
            180                 185                 190         


Cys Asn Ile Leu Trp Met His Arg Trp Val Lys Glu Lys Asn Ile Xaa 
        195                 200                 205             


Val Arg Asp Xaa Arg Cys Val Tyr Pro Lys Ser Leu Gln Ala Gln Pro 
    210                 215                 220                 


Val Xaa Gly Val Lys Gln Glu Leu Leu Xaa Cys Asp Pro Pro Leu Glu 
225                 230                 235                 240 


Leu Pro Ser Phe Tyr Met Xaa Pro Ser His Arg Gln Val Val Phe Glu 
                245                 250                 255     


Gly Asp Ser Leu Pro Phe Gln Cys Met Ala Ser Tyr Ile Asp Gln Asp 
            260                 265                 270         


Met Gln Val Leu Trp Tyr Gln Asp Gly Arg Ile Val Glu Xaa Asp Glu 
        275                 280                 285             


Ser Gln Gly Ile Phe Val Glu Lys Asn Met Ile His Asn Cys Ser Leu 
    290                 295                 300                 


Ile Ala Ser Ala Leu Xaa Ile Ser Asn Ile Gln Ala Gly Ser Xaa Gly 
305                 310                 315                 320 


Asn Trp Gly Cys His Val Gln Xaa Lys Arg Gly Asn Asn Xaa Arg Xaa 
                325                 330                 335     


Val Asp Ile Val Val Leu Glu Ser Ser Ala Gln Tyr Cys Pro Pro Glu 
            340                 345                 350         


Arg Val Val Asn Asn Lys Gly Asp Phe Arg Trp Pro Arg Xaa Leu Ala 
        355                 360                 365             


Gly Ile Xaa Ala Tyr Leu Gln Cys Xaa Arg Asn Xaa His Gly Ser Gly 
    370                 375                 380                 


Ile Tyr Pro Gly Asn Pro Gln Asp Glu Arg Lys Ala Trp Arg Arg Cys 
385                 390                 395                 400 


Asp Arg Gly Gly Phe Trp Ala Asp Asp Asp Tyr Ser Arg Cys Gln Tyr 
                405                 410                 415     


Ala Asn Asp Val Xaa Arg Val Leu Tyr Met Phe Asn Gln Met Pro Leu 
            420                 425                 430         


Asn Leu Xaa Asn Ala Val Ala Xaa Ala Arg Gln Leu Leu Ala Tyr Xaa 
        435                 440                 445             


Val Glu Ala Ala Asn Phe Ser Asp Lys Met Asp Val Ile Phe Val Ala 
    450                 455                 460                 


Glu Met Ile Glu Lys Phe Gly Arg Phe Xaa Lys Glu Glu Lys Ser Lys 
465                 470                 475                 480 


Glu Leu Gly Asp Val Met Val Asp Ile Ala Ser Asn Ile Met Leu Ala 
                485                 490                 495     


Asp Glu Arg Val Leu Trp Leu Ala Gln Arg Glu Ala Lys Ala Cys Ser 
            500                 505                 510         


Arg Ile Val Gln Cys Leu Gln Arg Ile Ala Xaa Tyr Arg Leu Ala Gly 
        515                 520                 525             


Gly Ala His Val Tyr Ser Xaa Tyr Ser Pro Asn Ile Ala Leu Glu Ala 
    530                 535                 540                 


Tyr Val Ile Lys Ser Xaa Gly Phe Xaa Gly Met Xaa Cys Xaa Val Phe 
545                 550                 555                 560 


Gln Lys Val Ala Ala Ser Asp Arg Xaa Gly Leu Ser Asp Tyr Gly Arg 
                565                 570                 575     


Arg Asp Pro Glu Gly Asn Leu Asp Lys Gln Leu Ser Phe Lys Cys Asn 
            580                 585                 590         


Val Ser Asn Xaa Phe Ser Ser Leu Ala Leu Lys Val Cys Tyr Ile Leu 
        595                 600                 605             


Gln Ser Phe Lys Xaa Ile Tyr Ser 
    610                 615     


<210> 1611
<211> 1321
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (983)..(983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1245)..(1245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1304)..(1304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1319)..(1320)
<223> Selenocysteine

<400> 1611
Met Glu Pro Pro Gly Arg Arg Arg Gly Arg Ala Gln Pro Pro Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Ala Leu Leu Ala Leu Leu Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Ala Ala Leu Pro Ala Gly Cys Lys His Asp Gly Arg 
        35                  40                  45              


Pro Arg Gly Ala Gly Arg Ala Ala Gly Ala Ala Glu Gly Lys Val Val 
    50                  55                  60                  


Cys Ser Ser Leu Glu Leu Ala Gln Val Leu Pro Pro Asp Xaa Leu Pro 
65                  70                  75                  80  


Asn Arg Xaa Val Xaa Leu Ile Leu Ser Asn Asn Lys Ile Ser Glu Leu 
                85                  90                  95      


Lys Asn Gly Ser Phe Ser Gly Leu Ser Leu Leu Glu Arg Leu Asp Leu 
            100                 105                 110         


Arg Asn Asn Leu Ile Ser Ser Ile Asp Pro Gly Ala Phe Trp Gly Leu 
        115                 120                 125             


Ser Ser Leu Lys Arg Leu Asp Leu Xaa Asn Asn Arg Ile Gly Cys Leu 
    130                 135                 140                 


Asn Ala Asp Ile Phe Arg Gly Leu Xaa Asn Leu Val Arg Leu Asn Leu 
145                 150                 155                 160 


Ser Gly Asn Leu Phe Ser Ser Leu Ser Gln Gly Xaa Phe Asp Tyr Leu 
                165                 170                 175     


Ala Ser Leu Arg Ser Leu Glu Phe Gln Xaa Glu Tyr Leu Leu Cys Asp 
            180                 185                 190         


Cys Asn Ile Leu Trp Met His Arg Trp Val Lys Glu Lys Asn Ile Xaa 
        195                 200                 205             


Val Arg Asp Xaa Arg Cys Val Tyr Pro Lys Ser Leu Gln Ala Gln Pro 
    210                 215                 220                 


Val Xaa Gly Val Lys Gln Glu Leu Leu Xaa Cys Asp Pro Pro Leu Glu 
225                 230                 235                 240 


Leu Pro Ser Phe Tyr Met Xaa Pro Ser His Arg Gln Val Val Phe Glu 
                245                 250                 255     


Gly Asp Ser Leu Pro Phe Gln Cys Met Ala Ser Tyr Ile Asp Gln Asp 
            260                 265                 270         


Met Gln Val Leu Trp Tyr Gln Asp Gly Arg Ile Val Glu Xaa Asp Glu 
        275                 280                 285             


Ser Gln Gly Ile Phe Val Glu Lys Asn Met Ile His Asn Cys Ser Leu 
    290                 295                 300                 


Ile Ala Ser Ala Leu Xaa Ile Ser Asn Ile Gln Ala Gly Ser Xaa Gly 
305                 310                 315                 320 


Asn Trp Gly Cys His Val Gln Xaa Lys Arg Gly Asn Asn Xaa Arg Xaa 
                325                 330                 335     


Val Asp Ile Val Val Leu Glu Ser Ser Ala Gln Tyr Cys Pro Pro Glu 
            340                 345                 350         


Arg Val Val Asn Asn Lys Gly Asp Phe Arg Trp Pro Arg Xaa Leu Ala 
        355                 360                 365             


Gly Ile Xaa Ala Tyr Leu Gln Cys Xaa Arg Asn Xaa His Gly Ser Gly 
    370                 375                 380                 


Ile Tyr Pro Gly Asn Pro Gln Asp Glu Arg Lys Ala Trp Arg Arg Cys 
385                 390                 395                 400 


Asp Arg Gly Gly Phe Trp Ala Asp Asp Asp Tyr Ser Arg Cys Gln Tyr 
                405                 410                 415     


Ala Asn Asp Val Xaa Arg Val Leu Tyr Met Phe Asn Gln Met Pro Leu 
            420                 425                 430         


Asn Leu Xaa Asn Ala Val Ala Xaa Ala Arg Gln Leu Leu Ala Tyr Xaa 
        435                 440                 445             


Val Glu Ala Ala Asn Phe Ser Asp Lys Met Asp Val Ile Phe Val Ala 
    450                 455                 460                 


Glu Met Ile Glu Lys Phe Gly Arg Phe Xaa Lys Glu Glu Lys Ser Lys 
465                 470                 475                 480 


Glu Leu Gly Asp Val Met Val Asp Ile Ala Ser Asn Ile Met Leu Ala 
                485                 490                 495     


Asp Glu Arg Val Leu Trp Leu Ala Gln Arg Glu Ala Lys Ala Cys Ser 
            500                 505                 510         


Arg Ile Val Gln Cys Leu Gln Arg Ile Ala Xaa Tyr Arg Leu Ala Gly 
        515                 520                 525             


Gly Ala His Val Tyr Ser Xaa Tyr Ser Pro Asn Ile Ala Leu Glu Ala 
    530                 535                 540                 


Tyr Val Ile Lys Ser Xaa Gly Phe Xaa Gly Met Xaa Cys Xaa Val Phe 
545                 550                 555                 560 


Gln Lys Val Ala Ala Ser Asp Arg Xaa Gly Leu Ser Asp Tyr Gly Arg 
                565                 570                 575     


Arg Asp Pro Glu Gly Asn Leu Asp Lys Gln Leu Ser Phe Lys Cys Asn 
            580                 585                 590         


Val Ser Asn Xaa Phe Ser Ser Leu Ala Leu Lys Asn Xaa Ile Val Glu 
        595                 600                 605             


Ala Ser Ile Gln Leu Pro Pro Ser Leu Phe Ser Pro Lys Gln Lys Arg 
    610                 615                 620                 


Glu Leu Arg Pro Xaa Asp Asp Ser Leu Tyr Lys Leu Gln Leu Ile Ala 
625                 630                 635                 640 


Phe Arg Asn Gly Lys Leu Phe Pro Ala Xaa Gly Asn Ser Xaa Asn Leu 
                645                 650                 655     


Ala Asp Asp Gly Lys Arg Arg Xaa Val Val Xaa Pro Val Ile Leu Xaa 
            660                 665                 670         


Lys Ile Asp Gly Val Asn Val Asp Xaa His His Ile Pro Val Asn Val 
        675                 680                 685             


Xaa Leu Arg Arg Ile Ala His Gly Ala Asp Ala Val Ala Ala Arg Trp 
    690                 695                 700                 


Asp Phe Asp Leu Leu Asn Gly Gln Gly Gly Trp Lys Ser Asp Gly Cys 
705                 710                 715                 720 


His Ile Leu Tyr Ser Asp Glu Asn Ile Xaa Xaa Ile Gln Cys Tyr Ser 
                725                 730                 735     


Leu Ser Asn Tyr Ala Val Leu Met Asp Leu Xaa Gly Ser Glu Leu Tyr 
            740                 745                 750         


Xaa Gln Ala Ala Ser Leu Leu His Pro Val Val Tyr Xaa Xaa Ala Ile 
        755                 760                 765             


Ile Leu Leu Leu Cys Leu Leu Ala Val Ile Val Ser Tyr Ile Tyr His 
    770                 775                 780                 


His Ser Leu Ile Arg Ile Ser Leu Lys Ser Trp His Met Leu Val Asn 
785                 790                 795                 800 


Leu Cys Phe His Ile Phe Leu Xaa Cys Val Val Phe Val Gly Gly Ile 
                805                 810                 815     


Xaa Gln Xaa Arg Asn Ala Ser Ile Cys Gln Ala Val Gly Ile Ile Leu 
            820                 825                 830         


His Tyr Ser Xaa Leu Ala Xaa Val Leu Trp Val Gly Val Xaa Ala Arg 
        835                 840                 845             


Asn Ile Tyr Lys Gln Val Xaa Lys Lys Ala Lys Arg Cys Gln Asp Pro 
    850                 855                 860                 


Asp Glu Pro Pro Pro Pro Pro Arg Pro Met Leu Arg Phe Tyr Leu Ile 
865                 870                 875                 880 


Gly Gly Gly Ile Pro Ile Ile Val Cys Gly Ile Xaa Ala Ala Ala Asn 
                885                 890                 895     


Ile Lys Asn Tyr Gly Ser Arg Pro Asn Ala Pro Tyr Cys Trp Met Ala 
            900                 905                 910         


Trp Glu Pro Ser Leu Gly Ala Phe Tyr Gly Pro Ala Ser Phe Ile Xaa 
        915                 920                 925             


Phe Val Asn Cys Met Tyr Phe Leu Ser Ile Phe Ile Gln Leu Lys Arg 
    930                 935                 940                 


His Pro Glu Arg Lys Tyr Glu Leu Lys Glu Pro Xaa Glu Glu Gln Gln 
945                 950                 955                 960 


Arg Leu Ala Ala Asn Glu Asn Gly Glu Ile Asn His Gln Asp Ser Met 
                965                 970                 975     


Ser Leu Ser Leu Ile Ser Xaa Ser Ala Leu Glu Asn Glu His Xaa Phe 
            980                 985                 990         


His Ser Gln Leu Leu Gly Ala Ser  Leu Xaa Leu Leu Leu  Tyr Val Ala 
        995                 1000                 1005             


Leu Trp  Met Phe Gly Ala Leu  Ala Val Ser Leu Tyr  Tyr Pro Leu 
    1010                 1015                 1020             


Asp Leu  Val Phe Ser Phe Val  Phe Gly Ala Xaa Ser  Leu Ser Phe 
    1025                 1030                 1035             


Ser Ala  Phe Phe Val Val His  His Cys Val Asn Arg  Glu Asp Val 
    1040                 1045                 1050             


Arg Leu  Ala Trp Ile Met Xaa  Cys Cys Pro Gly Arg  Ser Ser Tyr 
    1055                 1060                 1065             


Ser Val  Gln Val Asn Val Gln  Pro Pro Asn Ser Asn  Gly Xaa Asn 
    1070                 1075                 1080             


Gly Glu  Ala Pro Lys Cys Pro  Asn Ser Ser Ala Glu  Ser Ser Cys 
    1085                 1090                 1095             


Xaa Asn  Lys Ser Ala Ser Ser  Phe Lys Asn Ser Ser  Gln Gly Cys 
    1100                 1105                 1110             


Lys Leu  Xaa Asn Leu Gln Ala  Ala Ala Ala Gln Cys  His Ala Asn 
    1115                 1120                 1125             


Ser Leu  Pro Leu Asn Ser Xaa  Pro Gln Leu Asp Asn  Ser Leu Xaa 
    1130                 1135                 1140             


Glu His  Ser Met Asp Asn Asp  Ile Lys Met His Val  Ala Pro Leu 
    1145                 1150                 1155             


Glu Val  Gln Phe Arg Xaa Asn  Val His Ser Ser Arg  His His Lys 
    1160                 1165                 1170             


Asn Arg  Ser Lys Gly His Arg  Ala Ser Arg Leu Xaa  Val Leu Arg 
    1175                 1180                 1185             


Glu Tyr  Ala Tyr Asp Val Pro  Xaa Ser Val Glu Gly  Ser Val Gln 
    1190                 1195                 1200             


Asn Gly  Leu Pro Lys Ser Arg  Leu Gly Asn Asn Glu  Gly His Ser 
    1205                 1210                 1215             


Arg Ser  Arg Arg Ala Tyr Leu  Ala Tyr Arg Glu Arg  Gln Tyr Asn 
    1220                 1225                 1230             


Pro Pro  Gln Gln Asp Ser Ser  Asp Ala Cys Ser Xaa  Leu Pro Lys 
    1235                 1240                 1245             


Ser Ser  Arg Asn Phe Glu Lys  Pro Val Ser Xaa Xaa  Ser Lys Lys 
    1250                 1255                 1260             


Asp Ala  Leu Arg Lys Pro Ala  Val Val Glu Leu Glu  Asn Gln Gln 
    1265                 1270                 1275             


Lys Ser  Tyr Gly Leu Asn Leu  Ala Ile Gln Asn Gly  Pro Ile Lys 
    1280                 1285                 1290             


Ser Asn  Gly Gln Glu Gly Pro  Leu Leu Gly Xaa Asp  Ser Xaa Gly 
    1295                 1300                 1305             


Asn Val  Arg Xaa Gly Leu Trp  Lys His Glu Xaa Xaa  Val 
    1310                 1315                 1320     


<210> 1612
<211> 34
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<400> 1612
Met Leu Arg Phe Tyr Leu Ile Gly Gly Gly Ile Pro Ile Ile Val Cys 
1               5                   10                  15      


Gly Ile Xaa Ala Ala Ala Asn Ile Lys Asn Tyr Gly Ser Arg Pro Asn 
            20                  25                  30          


Ala Pro 
        


<210> 1613
<211> 381
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<400> 1613
Met Pro Leu Lys Arg Asn Asn Ser Lys Tyr Pro Pro Leu Glu Leu Pro 
1               5                   10                  15      


Ser Phe Tyr Met Xaa Pro Ser His Arg Gln Val Val Phe Glu Gly Asp 
            20                  25                  30          


Ser Leu Pro Phe Gln Cys Met Ala Ser Tyr Ile Asp Gln Asp Met Gln 
        35                  40                  45              


Val Leu Trp Tyr Gln Asp Gly Arg Ile Val Glu Xaa Asp Glu Ser Gln 
    50                  55                  60                  


Gly Ile Phe Val Glu Lys Asn Met Ile His Asn Cys Ser Leu Ile Ala 
65                  70                  75                  80  


Ser Ala Leu Xaa Ile Ser Asn Ile Gln Ala Gly Ser Xaa Gly Asn Trp 
                85                  90                  95      


Gly Cys His Val Gln Xaa Lys Arg Gly Asn Asn Xaa Arg Xaa Val Asp 
            100                 105                 110         


Ile Val Val Leu Glu Ser Ser Ala Gln Tyr Cys Pro Pro Glu Arg Val 
        115                 120                 125             


Val Asn Asn Lys Gly Asp Phe Arg Trp Pro Arg Xaa Leu Ala Gly Ile 
    130                 135                 140                 


Xaa Ala Tyr Leu Gln Cys Xaa Arg Asn Xaa His Gly Ser Gly Ile Tyr 
145                 150                 155                 160 


Pro Gly Asn Pro Gln Asp Glu Arg Lys Ala Trp Arg Arg Cys Asp Arg 
                165                 170                 175     


Gly Gly Phe Trp Ala Asp Asp Asp Tyr Ser Arg Cys Gln Tyr Ala Asn 
            180                 185                 190         


Asp Val Xaa Arg Val Leu Tyr Met Phe Asn Gln Met Pro Leu Asn Leu 
        195                 200                 205             


Xaa Asn Ala Val Ala Xaa Ala Arg Gln Leu Leu Ala Tyr Xaa Val Glu 
    210                 215                 220                 


Ala Ala Asn Phe Ser Asp Lys Met Asp Val Ile Phe Val Ala Glu Met 
225                 230                 235                 240 


Ile Glu Lys Phe Gly Arg Phe Xaa Lys Glu Glu Lys Ser Lys Glu Leu 
                245                 250                 255     


Gly Asp Val Met Val Asp Ile Ala Ser Asn Ile Met Leu Ala Asp Glu 
            260                 265                 270         


Arg Val Leu Trp Leu Ala Gln Arg Glu Ala Lys Ala Cys Ser Arg Ile 
        275                 280                 285             


Val Gln Cys Leu Gln Arg Ile Ala Xaa Tyr Arg Leu Ala Gly Gly Ala 
    290                 295                 300                 


His Val Tyr Ser Xaa Tyr Ser Pro Asn Ile Ala Leu Glu Ala Tyr Val 
305                 310                 315                 320 


Ile Lys Ser Xaa Gly Phe Xaa Gly Met Xaa Cys Xaa Val Phe Gln Lys 
                325                 330                 335     


Val Ala Ala Ser Asp Arg Xaa Gly Leu Ser Asp Tyr Gly Arg Arg Asp 
            340                 345                 350         


Pro Glu Gly Asn Leu Asp Lys Gln Leu Ser Phe Lys Cys Asn Val Ser 
        355                 360                 365             


Asn Xaa Phe Ser Ser Leu Ala Leu Lys Gly Lys Phe Arg 
    370                 375                 380     


<210> 1614
<211> 1159
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<400> 1614
Met Arg Gly Gln Ala Ala Ala Pro Gly Pro Val Trp Ile Leu Ala Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Gly Arg Arg Ala Arg Ala Ala Ala 
            20                  25                  30          


Gly Ala Asp Ala Gly Pro Gly Pro Glu Pro Cys Ala Xaa Leu Val Gln 
        35                  40                  45              


Gly Lys Phe Phe Gly Tyr Phe Ser Ala Ala Ala Val Phe Pro Ala Asn 
    50                  55                  60                  


Ala Ser Arg Cys Ser Trp Xaa Leu Arg Asn Pro Asp Pro Arg Arg Tyr 
65                  70                  75                  80  


Xaa Leu Tyr Met Lys Val Ala Lys Ala Pro Val Pro Cys Ser Gly Pro 
                85                  90                  95      


Gly Arg Val Arg Xaa Tyr Gln Phe Asp Ser Phe Leu Glu Ser Xaa Arg 
            100                 105                 110         


Xaa Tyr Leu Gly Val Glu Ser Phe Asp Glu Val Leu Arg Leu Cys Asp 
        115                 120                 125             


Pro Ser Ala Pro Leu Ala Phe Leu Gln Ala Ser Lys Gln Phe Leu Gln 
    130                 135                 140                 


Met Arg Arg Gln Gln Pro Pro Gln His Asp Gly Leu Arg Pro Arg Ala 
145                 150                 155                 160 


Gly Pro Pro Gly Pro Xaa Asp Asp Phe Ser Val Glu Tyr Leu Val Val 
                165                 170                 175     


Gly Asn Arg Asn Pro Ser Arg Ala Ala Cys Gln Met Leu Cys Arg Trp 
            180                 185                 190         


Leu Asp Ala Cys Leu Ala Gly Ser Arg Ser Ser His Pro Cys Gly Ile 
        195                 200                 205             


Met Gln Xaa Pro Cys Ala Cys Leu Gly Gly Glu Ala Gly Gly Pro Ala 
    210                 215                 220                 


Ala Gly Pro Leu Ala Pro Arg Gly Asp Val Cys Leu Arg Asp Ala Val 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asn Cys Leu Xaa Ser Leu Xaa Gln Asp Arg Gly 
                245                 250                 255     


Gly His Gly Ala Xaa Gly Gly Trp Lys Leu Trp Ser Leu Trp Gly Glu 
            260                 265                 270         


Cys Xaa Arg Asp Cys Gly Gly Gly Leu Gln Xaa Arg Xaa Arg Xaa Cys 
        275                 280                 285             


Leu Pro Ala Pro Gly Val Glu Gly Gly Gly Cys Glu Gly Val Leu Glu 
    290                 295                 300                 


Glu Gly Arg Gln Cys Asn Arg Glu Ala Cys Gly Pro Ala Gly Arg Xaa 
305                 310                 315                 320 


Ser Ser Arg Ser Gln Ser Leu Arg Ser Xaa Asp Ala Arg Arg Arg Glu 
                325                 330                 335     


Glu Leu Gly Asp Glu Leu Gln Gln Phe Gly Phe Pro Ala Pro Gln Xaa 
            340                 345                 350         


Gly Asp Pro Ala Ala Glu Glu Trp Ser Pro Trp Ser Val Cys Ser Ser 
        355                 360                 365             


Xaa Cys Gly Glu Gly Trp Gln Xaa Arg Xaa Arg Phe Cys Val Ser Ser 
    370                 375                 380                 


Ser Tyr Ser Xaa Gln Cys Ser Gly Pro Leu Arg Glu Gln Arg Leu Cys 
385                 390                 395                 400 


Asn Asn Ser Ala Val Cys Pro Val His Gly Ala Trp Asp Glu Trp Ser 
                405                 410                 415     


Pro Trp Ser Leu Cys Ser Ser Xaa Cys Gly Arg Gly Phe Arg Asp Arg 
            420                 425                 430         


Xaa Arg Xaa Cys Arg Pro Pro Gln Phe Gly Gly Asn Pro Cys Glu Gly 
        435                 440                 445             


Pro Glu Lys Gln Xaa Lys Phe Cys Asn Ile Ala Leu Cys Pro Gly Arg 
    450                 455                 460                 


Ala Val Asp Gly Asn Trp Asn Glu Trp Ser Ser Trp Ser Ala Cys Ser 
465                 470                 475                 480 


Ala Ser Cys Ser Gln Gly Arg Gln Gln Arg Xaa Arg Glu Cys Asn Gly 
                485                 490                 495     


Pro Ser Tyr Gly Gly Ala Glu Cys Gln Gly His Trp Val Glu Xaa Arg 
            500                 505                 510         


Asp Cys Phe Leu Gln Gln Cys Pro Val Asp Gly Lys Trp Gln Ala Trp 
        515                 520                 525             


Ala Ser Trp Gly Ser Cys Ser Val Xaa Cys Gly Ala Gly Ser Gln Arg 
    530                 535                 540                 


Arg Glu Arg Val Cys Ser Gly Pro Phe Phe Gly Gly Ala Ala Cys Gln 
545                 550                 555                 560 


Gly Pro Gln Asp Glu Tyr Arg Gln Cys Gly Xaa Gln Arg Cys Pro Glu 
                565                 570                 575     


Pro His Glu Ile Cys Asp Glu Asp Asn Phe Gly Ala Val Ile Trp Lys 
            580                 585                 590         


Glu Xaa Pro Ala Gly Glu Val Ala Ala Val Arg Cys Pro Arg Asn Ala 
        595                 600                 605             


Xaa Gly Leu Ile Leu Arg Arg Cys Glu Leu Asp Glu Glu Gly Ile Ala 
    610                 615                 620                 


Tyr Trp Glu Pro Pro Xaa Tyr Ile Arg Cys Val Ser Ile Asp Tyr Arg 
625                 630                 635                 640 


Asn Ile Gln Met Met Xaa Arg Glu His Leu Ala Lys Ala Gln Arg Gly 
                645                 650                 655     


Leu Pro Gly Glu Gly Val Ser Glu Val Ile Gln Xaa Leu Val Glu Ile 
            660                 665                 670         


Ser Gln Asp Gly Xaa Ser Tyr Ser Gly Asp Leu Leu Ser Xaa Ile Asp 
        675                 680                 685             


Val Leu Arg Asn Met Xaa Glu Ile Phe Arg Arg Ala Tyr Tyr Ser Pro 
    690                 695                 700                 


Xaa Pro Gly Asp Val Gln Asn Phe Val Gln Ile Leu Ser Asn Leu Leu 
705                 710                 715                 720 


Ala Glu Glu Asn Arg Asp Lys Trp Glu Glu Ala Gln Leu Ala Gly Pro 
                725                 730                 735     


Asn Ala Lys Glu Leu Phe Arg Leu Val Glu Asp Phe Val Asp Val Ile 
            740                 745                 750         


Gly Phe Arg Met Lys Asp Leu Arg Asp Ala Tyr Gln Val Xaa Asp Asn 
        755                 760                 765             


Leu Val Leu Ser Ile His Lys Leu Pro Ala Ser Gly Ala Xaa Asp Ile 
    770                 775                 780                 


Ser Phe Pro Met Lys Gly Trp Arg Ala Xaa Gly Asp Trp Ala Lys Val 
785                 790                 795                 800 


Pro Glu Asp Arg Val Xaa Val Ser Lys Ser Val Phe Ser Xaa Gly Leu 
                805                 810                 815     


Xaa Glu Ala Asp Glu Ala Ser Val Phe Val Val Gly Xaa Val Leu Tyr 
            820                 825                 830         


Arg Asn Leu Gly Ser Phe Leu Ala Leu Gln Arg Asn Xaa Xaa Val Leu 
        835                 840                 845             


Asn Ser Lys Val Ile Ser Val Xaa Val Lys Pro Pro Pro Arg Ser Leu 
    850                 855                 860                 


Arg Xaa Pro Leu Glu Ile Glu Phe Ala His Met Tyr Asn Gly Xaa Xaa 
865                 870                 875                 880 


Asn Gln Xaa Cys Ile Leu Trp Asp Glu Xaa Asp Val Pro Ser Ser Ser 
                885                 890                 895     


Ala Pro Pro Gln Leu Gly Pro Trp Ser Trp Arg Gly Cys Arg Xaa Val 
            900                 905                 910         


Pro Leu Asp Ala Leu Arg Xaa Arg Cys Leu Cys Asp Arg Leu Ser Xaa 
        915                 920                 925             


Phe Ala Ile Leu Ala Gln Leu Ser Ala Asp Ala Asn Met Glu Lys Ala 
    930                 935                 940                 


Xaa Leu Pro Ser Val Xaa Leu Ile Val Gly Cys Gly Val Ser Ser Leu 
945                 950                 955                 960 


Xaa Leu Leu Met Leu Val Ile Ile Tyr Val Ser Val Trp Arg Tyr Ile 
                965                 970                 975     


Arg Ser Glu Arg Ser Val Ile Leu Ile Asn Phe Cys Leu Ser Ile Ile 
            980                 985                 990         


Ser Ser Asn Ala Leu Ile Leu Ile  Gly Gln Xaa Gln Xaa  Arg Asn Lys 
        995                 1000                 1005             


Val Val  Cys Xaa Leu Val Ala  Ala Phe Leu His Phe  Phe Phe Leu 
    1010                 1015                 1020             


Ser Ser  Phe Cys Trp Val Leu  Xaa Glu Ala Trp Gln  Ser Tyr Met 
    1025                 1030                 1035             


Ala Val  Xaa Gly His Leu Arg  Asn Arg Leu Ile Arg  Lys Arg Phe 
    1040                 1045                 1050             


Leu Cys  Leu Gly Trp Gly Leu  Pro Ala Leu Val Val  Ala Ile Ser 
    1055                 1060                 1065             


Val Gly  Phe Xaa Lys Ala Lys  Gly Tyr Ser Xaa Met  Asn Tyr Cys 
    1070                 1075                 1080             


Trp Leu  Ser Leu Glu Gly Gly  Leu Leu Tyr Ala Phe  Val Gly Pro 
    1085                 1090                 1095             


Ala Ala  Ala Val Val Leu Gly  Leu Pro Val Glu Leu  Leu Arg Gly 
    1100                 1105                 1110             


Ala Ala  Ala Ala Gly Ala Asp  Leu Asp Val Gly Cys  Ala Arg Arg 
    1115                 1120                 1125             


His Arg  Pro Pro Leu Arg Pro  Leu Pro Asp Pro Leu  Arg Cys Leu 
    1130                 1135                 1140             


Arg Leu  Ala Gly Gly Leu Arg  His Arg His Gly Ala  Leu Tyr Pro 
    1145                 1150                 1155             


Pro 
    


<210> 1615
<211> 1584
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1246)..(1246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1248)..(1248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1252)..(1252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1308)..(1308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1343)..(1343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1354)..(1354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1375)..(1375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1382)..(1382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1453)..(1453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1464)..(1464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1488)..(1488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1525)..(1525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1540)..(1540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1569)..(1569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<400> 1615
Met Arg Gly Gln Ala Ala Ala Pro Gly Pro Val Trp Ile Leu Ala Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Gly Arg Arg Ala Arg Ala Ala Ala 
            20                  25                  30          


Gly Ala Asp Ala Gly Pro Gly Pro Glu Pro Cys Ala Xaa Leu Val Gln 
        35                  40                  45              


Gly Lys Phe Phe Gly Tyr Phe Ser Ala Ala Ala Val Phe Pro Ala Asn 
    50                  55                  60                  


Ala Ser Arg Cys Ser Trp Xaa Leu Arg Asn Pro Asp Pro Arg Arg Tyr 
65                  70                  75                  80  


Xaa Leu Tyr Met Lys Val Ala Lys Ala Pro Val Pro Cys Ser Gly Pro 
                85                  90                  95      


Gly Arg Val Arg Xaa Tyr Gln Phe Asp Ser Phe Leu Glu Ser Xaa Arg 
            100                 105                 110         


Xaa Tyr Leu Gly Val Glu Ser Phe Asp Glu Val Leu Arg Leu Cys Asp 
        115                 120                 125             


Pro Ser Ala Pro Leu Ala Phe Leu Gln Ala Ser Lys Gln Phe Leu Gln 
    130                 135                 140                 


Met Arg Arg Gln Gln Pro Pro Gln His Asp Gly Leu Arg Pro Arg Ala 
145                 150                 155                 160 


Gly Pro Pro Gly Pro Xaa Asp Asp Phe Ser Val Glu Tyr Leu Val Val 
                165                 170                 175     


Gly Asn Arg Asn Pro Ser Arg Ala Ala Cys Gln Met Leu Cys Arg Trp 
            180                 185                 190         


Leu Asp Ala Cys Leu Ala Gly Ser Arg Ser Ser His Pro Cys Gly Ile 
        195                 200                 205             


Met Gln Xaa Pro Cys Ala Cys Leu Gly Gly Glu Ala Gly Gly Pro Ala 
    210                 215                 220                 


Ala Gly Pro Leu Ala Pro Arg Gly Asp Val Cys Leu Arg Asp Ala Val 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asn Cys Leu Xaa Ser Leu Xaa Gln Asp Arg Gly 
                245                 250                 255     


Gly His Gly Ala Xaa Gly Gly Trp Lys Leu Trp Ser Leu Trp Gly Glu 
            260                 265                 270         


Cys Xaa Arg Asp Cys Gly Gly Gly Leu Gln Xaa Arg Xaa Arg Xaa Cys 
        275                 280                 285             


Leu Pro Ala Pro Gly Val Glu Gly Gly Gly Cys Glu Gly Val Leu Glu 
    290                 295                 300                 


Glu Gly Arg Gln Cys Asn Arg Glu Ala Cys Gly Pro Ala Gly Arg Xaa 
305                 310                 315                 320 


Ser Ser Arg Ser Gln Ser Leu Arg Ser Xaa Asp Ala Arg Arg Arg Glu 
                325                 330                 335     


Glu Leu Gly Asp Glu Leu Gln Gln Phe Gly Phe Pro Ala Pro Gln Xaa 
            340                 345                 350         


Gly Asp Pro Ala Ala Glu Glu Trp Ser Pro Trp Ser Val Cys Ser Ser 
        355                 360                 365             


Xaa Cys Gly Glu Gly Trp Gln Xaa Arg Xaa Arg Phe Cys Val Ser Ser 
    370                 375                 380                 


Ser Tyr Ser Xaa Gln Cys Ser Gly Pro Leu Arg Glu Gln Arg Leu Cys 
385                 390                 395                 400 


Asn Asn Ser Ala Val Cys Pro Val His Gly Ala Trp Asp Glu Trp Ser 
                405                 410                 415     


Pro Trp Ser Leu Cys Ser Ser Xaa Cys Gly Arg Gly Phe Arg Asp Arg 
            420                 425                 430         


Xaa Arg Xaa Cys Arg Pro Pro Gln Phe Gly Gly Asn Pro Cys Glu Gly 
        435                 440                 445             


Pro Glu Lys Gln Xaa Lys Phe Cys Asn Ile Ala Leu Cys Pro Gly Arg 
    450                 455                 460                 


Ala Val Asp Gly Asn Trp Asn Glu Trp Ser Ser Trp Ser Ala Cys Ser 
465                 470                 475                 480 


Ala Ser Cys Ser Gln Gly Arg Gln Gln Arg Xaa Arg Glu Cys Asn Gly 
                485                 490                 495     


Pro Ser Tyr Gly Gly Ala Glu Cys Gln Gly His Trp Val Glu Xaa Arg 
            500                 505                 510         


Asp Cys Phe Leu Gln Gln Cys Pro Val Asp Gly Lys Trp Gln Ala Trp 
        515                 520                 525             


Ala Ser Trp Gly Ser Cys Ser Val Xaa Cys Gly Ala Gly Ser Gln Arg 
    530                 535                 540                 


Arg Glu Arg Val Cys Ser Gly Pro Phe Phe Gly Gly Ala Ala Cys Gln 
545                 550                 555                 560 


Gly Pro Gln Asp Glu Tyr Arg Gln Cys Gly Xaa Gln Arg Cys Pro Glu 
                565                 570                 575     


Pro His Glu Ile Cys Asp Glu Asp Asn Phe Gly Ala Val Ile Trp Lys 
            580                 585                 590         


Glu Xaa Pro Ala Gly Glu Val Ala Ala Val Arg Cys Pro Arg Asn Ala 
        595                 600                 605             


Xaa Gly Leu Ile Leu Arg Arg Cys Glu Leu Asp Glu Glu Gly Ile Ala 
    610                 615                 620                 


Tyr Trp Glu Pro Pro Xaa Tyr Ile Arg Cys Val Ser Ile Asp Tyr Arg 
625                 630                 635                 640 


Asn Ile Gln Met Met Xaa Arg Glu His Leu Ala Lys Ala Gln Arg Gly 
                645                 650                 655     


Leu Pro Gly Glu Gly Val Ser Glu Val Ile Gln Xaa Leu Val Glu Ile 
            660                 665                 670         


Ser Gln Asp Gly Xaa Ser Tyr Ser Gly Asp Leu Leu Ser Xaa Ile Asp 
        675                 680                 685             


Val Leu Arg Asn Met Xaa Glu Ile Phe Arg Arg Ala Tyr Tyr Ser Pro 
    690                 695                 700                 


Xaa Pro Gly Asp Val Gln Asn Phe Val Gln Ile Leu Ser Asn Leu Leu 
705                 710                 715                 720 


Ala Glu Glu Asn Arg Asp Lys Trp Glu Glu Ala Gln Leu Ala Gly Pro 
                725                 730                 735     


Asn Ala Lys Glu Leu Phe Arg Leu Val Glu Asp Phe Val Asp Val Ile 
            740                 745                 750         


Gly Phe Arg Met Lys Asp Leu Arg Asp Ala Tyr Gln Val Xaa Asp Asn 
        755                 760                 765             


Leu Val Leu Ser Ile His Lys Leu Pro Ala Ser Gly Ala Xaa Asp Ile 
    770                 775                 780                 


Ser Phe Pro Met Lys Gly Trp Arg Ala Xaa Gly Asp Trp Ala Lys Val 
785                 790                 795                 800 


Pro Glu Asp Arg Val Xaa Val Ser Lys Ser Val Phe Ser Xaa Gly Leu 
                805                 810                 815     


Xaa Glu Ala Asp Glu Ala Ser Val Phe Val Val Gly Xaa Val Leu Tyr 
            820                 825                 830         


Arg Asn Leu Gly Ser Phe Leu Ala Leu Gln Arg Asn Xaa Xaa Val Leu 
        835                 840                 845             


Asn Ser Lys Val Ile Ser Val Xaa Val Lys Pro Pro Pro Arg Ser Leu 
    850                 855                 860                 


Arg Xaa Pro Leu Glu Ile Glu Phe Ala His Met Tyr Asn Gly Xaa Xaa 
865                 870                 875                 880 


Asn Gln Xaa Cys Ile Leu Trp Asp Glu Xaa Asp Val Pro Ser Ser Ser 
                885                 890                 895     


Ala Pro Pro Gln Leu Gly Pro Trp Ser Trp Arg Gly Cys Arg Xaa Val 
            900                 905                 910         


Pro Leu Asp Ala Leu Arg Xaa Arg Cys Leu Cys Asp Arg Leu Ser Xaa 
        915                 920                 925             


Phe Ala Ile Leu Ala Gln Leu Ser Ala Asp Ala Asn Met Glu Lys Ala 
    930                 935                 940                 


Xaa Leu Pro Ser Val Xaa Leu Ile Val Gly Cys Gly Val Ser Ser Leu 
945                 950                 955                 960 


Xaa Leu Leu Met Leu Val Ile Ile Tyr Val Ser Val Trp Arg Tyr Ile 
                965                 970                 975     


Arg Ser Glu Arg Ser Val Ile Leu Ile Asn Phe Cys Leu Ser Ile Ile 
            980                 985                 990         


Ser Ser Asn Ala Leu Ile Leu Ile  Gly Gln Xaa Gln Xaa  Arg Asn Lys 
        995                 1000                 1005             


Val Val  Cys Xaa Leu Val Ala  Ala Phe Leu His Phe  Phe Phe Leu 
    1010                 1015                 1020             


Ser Ser  Phe Cys Trp Val Leu  Xaa Glu Ala Trp Gln  Ser Tyr Met 
    1025                 1030                 1035             


Ala Val  Xaa Gly His Leu Arg  Asn Arg Leu Ile Arg  Lys Arg Phe 
    1040                 1045                 1050             


Leu Cys  Leu Gly Trp Gly Leu  Pro Ala Leu Val Val  Ala Ile Ser 
    1055                 1060                 1065             


Val Gly  Phe Xaa Lys Ala Lys  Gly Tyr Ser Xaa Met  Asn Tyr Cys 
    1070                 1075                 1080             


Trp Leu  Ser Leu Glu Gly Gly  Leu Leu Tyr Ala Phe  Val Gly Pro 
    1085                 1090                 1095             


Ala Ala  Ala Val Val Leu Val  Asn Met Val Ile Gly  Ile Leu Val 
    1100                 1105                 1110             


Phe Asn  Lys Leu Val Ser Lys  Asp Gly Ile Xaa Asp  Lys Lys Leu 
    1115                 1120                 1125             


Lys Glu  Arg Ala Gly Ala Ser  Leu Trp Ser Ser Cys  Val Val Leu 
    1130                 1135                 1140             


Pro Leu  Leu Ala Leu Xaa Trp  Met Ser Ala Val Leu  Ala Val Xaa 
    1145                 1150                 1155             


Asp Arg  Arg Ser Ala Leu Phe  Gln Ile Leu Phe Ala  Val Phe Asp 
    1160                 1165                 1170             


Ser Leu  Glu Gly Phe Val Ile  Val Met Val His Cys  Ile Leu Arg 
    1175                 1180                 1185             


Arg Glu  Val Gln Asp Ala Val  Lys Cys Arg Val Val  Asp Arg Gln 
    1190                 1195                 1200             


Glu Glu  Gly Asn Gly Asp Ser  Gly Gly Ser Phe Gln  Asn Gly His 
    1205                 1210                 1215             


Ala Gln  Leu Met Xaa Asp Phe  Glu Lys Asp Val Asp  Leu Ala Cys 
    1220                 1225                 1230             


Arg Ser  Val Leu Asn Lys Asp  Ile Ala Ala Cys Arg  Xaa Ala Xaa 
    1235                 1240                 1245             


Ile Xaa  Gly Xaa Leu Lys Arg  Pro Ser Leu Pro Glu  Glu Glu Lys 
    1250                 1255                 1260             


Leu Lys  Leu Ala His Ala Lys  Gly Pro Pro Xaa Asn  Phe Asn Ser 
    1265                 1270                 1275             


Leu Pro  Ala Asn Val Ser Lys  Leu His Leu His Gly  Ser Pro Arg 
    1280                 1285                 1290             


Tyr Pro  Gly Gly Pro Leu Pro  Asp Phe Pro Asn His  Ser Leu Xaa 
    1295                 1300                 1305             


Leu Lys  Arg Asp Lys Ala Pro  Lys Ser Ser Phe Val  Gly Asp Gly 
    1310                 1315                 1320             


Asp Ile  Phe Lys Lys Leu Asp  Ser Glu Leu Ser Arg  Ala Gln Glu 
    1325                 1330                 1335             


Lys Ala  Leu Asp Xaa Ser Tyr  Val Ile Leu Pro Xaa  Ala Xaa Ala 
    1340                 1345                 1350             


Xaa Leu  Arg Pro Lys Pro Lys  Glu Glu Pro Lys Tyr  Ser Ile His 
    1355                 1360                 1365             


Ile Asp  Gln Met Pro Gln Xaa  Arg Leu Ile His Leu  Ser Xaa Ala 
    1370                 1375                 1380             


Pro Glu  Ala Ser Leu Pro Ala  Arg Ser Pro Pro Ser  Arg Gln Pro 
    1385                 1390                 1395             


Pro Ser  Gly Gly Pro Pro Glu  Ala Pro Pro Ala Gln  Pro Pro Pro 
    1400                 1405                 1410             


Pro Pro  Pro Pro Pro Pro Pro  Pro Pro Gln Gln Pro  Leu Pro Pro 
    1415                 1420                 1425             


Pro Pro  Asn Leu Glu Pro Ala  Pro Pro Ser Leu Gly  Asp Pro Gly 
    1430                 1435                 1440             


Glu Pro  Ala Ala His Pro Gly  Pro Ser Xaa Gly Pro  Ser Xaa Lys 
    1445                 1450                 1455             


Asn Glu  Asn Val Ala Xaa Leu  Ser Val Ser Ser Leu  Glu Arg Arg 
    1460                 1465                 1470             


Lys Ser  Arg Tyr Ala Glu Leu  Asp Phe Glu Lys Ile  Met His Xaa 
    1475                 1480                 1485             


Arg Lys  Arg His Gln Asp Met  Phe Gln Asp Leu Asn  Arg Lys Leu 
    1490                 1495                 1500             


Gln His  Ala Ala Glu Lys Asp  Lys Glu Val Leu Gly  Pro Asp Ser 
    1505                 1510                 1515             


Lys Pro  Glu Lys Gln Gln Xaa  Pro Asn Lys Arg Pro  Trp Glu Ser 
    1520                 1525                 1530             


Leu Arg  Lys Ala His Gly Xaa  Pro Xaa Trp Val Lys  Lys Glu Leu 
    1535                 1540                 1545             


Glu Pro  Leu Gln Pro Ser Pro  Leu Glu Leu Arg Ser  Val Glu Trp 
    1550                 1555                 1560             


Glu Arg  Ser Gly Ala Xaa Ile  Pro Leu Val Gly Gln  Asp Ile Ile 
    1565                 1570                 1575             


Asp Leu  Gln Xaa Glu Val 
    1580                 


<210> 1616
<211> 847
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<400> 1616
Gly Lys Gly His Arg Met Xaa Pro Ala Cys Pro Leu Leu Leu Ser Val 
1               5                   10                  15      


Ile Leu Ser Leu Arg Leu Ala Xaa Ala Phe Asp Pro Ala Pro Ser Ala 
            20                  25                  30          


Cys Ser Ala Leu Ala Ser Gly Val Leu Tyr Gly Ala Phe Ser Leu Gln 
        35                  40                  45              


Asp Leu Phe Pro Xaa Ile Ala Ser Gly Cys Ser Trp Xaa Leu Glu Asn 
    50                  55                  60                  


Pro Asp Pro Xaa Lys Tyr Ser Leu Tyr Leu Arg Phe Asn Arg Gln Glu 
65                  70                  75                  80  


Gln Val Cys Ala His Phe Ala Pro Arg Leu Leu Pro Leu Asp His Tyr 
                85                  90                  95      


Leu Val Asn Phe Xaa Cys Leu Arg Pro Ser Pro Glu Glu Ala Val Ala 
            100                 105                 110         


Gln Ala Glu Ser Glu Val Gly Arg Pro Glu Glu Glu Glu Ala Glu Ala 
        115                 120                 125             


Ala Ala Gly Leu Glu Leu Cys Ser Gly Ser Gly Pro Phe Xaa Phe Leu 
    130                 135                 140                 


His Phe Asp Lys Asn Phe Val Gln Leu Cys Leu Ser Ala Glu Pro Ser 
145                 150                 155                 160 


Glu Ala Pro Arg Leu Leu Ala Pro Ala Ala Leu Ala Phe Arg Phe Val 
                165                 170                 175     


Glu Val Leu Leu Ile Asn Asn Asn Asn Ser Ser Gln Phe Xaa Cys Gly 
            180                 185                 190         


Val Leu Cys Arg Trp Ser Glu Glu Cys Gly Arg Ala Ala Gly Arg Ala 
        195                 200                 205             


Cys Gly Phe Ala Gln Pro Gly Cys Ser Cys Pro Gly Glu Ala Gly Ala 
    210                 215                 220                 


Gly Ser Xaa Xaa Xaa Xaa Ser Pro Gly Pro Pro Ala Ala His Xaa Leu 
225                 230                 235                 240 


Ser Asn Ala Leu Val Pro Gly Gly Pro Ala Pro Pro Ala Glu Ala Asp 
                245                 250                 255     


Leu His Ser Gly Ser Ser Asn Asp Leu Phe Xaa Xaa Glu Met Arg Tyr 
            260                 265                 270         


Gly Glu Glu Pro Glu Glu Glu Pro Lys Val Lys Xaa Gln Trp Pro Arg 
        275                 280                 285             


Ser Ala Asp Glu Pro Gly Leu Tyr Met Ala Gln Xaa Gly Asp Pro Ala 
    290                 295                 300                 


Ala Glu Glu Trp Ser Pro Trp Ser Val Cys Ser Leu Xaa Cys Gly Gln 
305                 310                 315                 320 


Gly Leu Gln Val Arg Xaa Arg Ser Cys Val Ser Ser Pro Tyr Gly Xaa 
                325                 330                 335     


Leu Cys Ser Gly Pro Leu Arg Glu Xaa Arg Pro Cys Asn Asn Ser Ala 
            340                 345                 350         


Xaa Cys Pro Val Glu Gly Gln Trp Leu Glu Trp Gly Pro Trp Gly Pro 
        355                 360                 365             


Cys Ser Xaa Ser Cys Ala Asn Gly Xaa Gln Gln Arg Ser Arg Lys Cys 
    370                 375                 380                 


Ser Val Ala Gly Pro Ala Trp Ala Xaa Cys Xaa Gly Ala Leu Xaa Asp 
385                 390                 395                 400 


Xaa Arg Glu Cys Ser Asn Leu Glu Cys Pro Ala Xaa Asp Ser Lys Trp 
                405                 410                 415     


Gly Pro Trp Asn Ala Trp Ser Leu Cys Ser Lys Xaa Cys Asp Xaa Gly 
            420                 425                 430         


Trp Gln Arg Arg Phe Arg Met Cys Gln Ala Xaa Gly Xaa Gln Gly Tyr 
        435                 440                 445             


Pro Cys Glu Gly Xaa Gly Glu Glu Val Lys Pro Cys Ser Glu Lys Arg 
    450                 455                 460                 


Cys Pro Ala Phe His Glu Met Cys Arg Asp Glu Tyr Val Met Leu Met 
465                 470                 475                 480 


Xaa Trp Lys Lys Ala Ala Ala Gly Glu Ile Ile Tyr Asn Lys Cys Pro 
                485                 490                 495     


Pro Asn Ala Ser Gly Ser Ala Ser Arg Arg Cys Leu Leu Ser Ala Gln 
            500                 505                 510         


Gly Val Ala Tyr Trp Gly Leu Pro Ser Phe Ala Arg Cys Ile Ser His 
        515                 520                 525             


Glu Tyr Arg Tyr Leu Tyr Leu Ser Leu Arg Glu His Leu Ala Lys Gly 
    530                 535                 540                 


Gln Arg Met Leu Ala Gly Glu Gly Met Ser Gln Val Val Arg Ser Leu 
545                 550                 555                 560 


Gln Glu Leu Leu Ala Arg Arg Xaa Tyr Tyr Ser Gly Asp Leu Leu Phe 
                565                 570                 575     


Ser Val Asp Ile Leu Arg Asn Val Xaa Asp Xaa Phe Lys Arg Ala Xaa 
            580                 585                 590         


Tyr Val Pro Ser Ala Asp Asp Val Gln Arg Phe Phe Gln Val Val Ser 
        595                 600                 605             


Phe Met Val Asp Ala Glu Asn Lys Glu Lys Trp Asp Asp Ala Gln Gln 
    610                 615                 620                 


Val Ser Pro Gly Ser Val His Leu Leu Arg Val Val Glu Asp Phe Ile 
625                 630                 635                 640 


His Leu Val Gly Asp Ala Leu Lys Ala Phe Gln Ser Ser Leu Ile Val 
                645                 650                 655     


Xaa Asp Asn Leu Val Ile Ser Ile Gln Arg Glu Pro Val Ser Ala Val 
            660                 665                 670         


Ser Ser Asp Ile Xaa Phe Pro Met Arg Gly Arg Arg Gly Met Lys Asp 
        675                 680                 685             


Trp Val Arg His Ser Glu Asp Arg Leu Phe Leu Pro Lys Glu Val Leu 
    690                 695                 700                 


Ser Leu Ser Ser Pro Gly Lys Pro Ala Xaa Ser Gly Ala Ala Gly Ser 
705                 710                 715                 720 


Pro Gly Arg Gly Arg Gly Pro Gly Xaa Val Pro Pro Gly Pro Gly His 
                725                 730                 735     


Ser His Gln Arg Leu Leu Pro Ala Asp Pro Asp Glu Ser Ser Tyr Phe 
            740                 745                 750         


Val Ile Gly Ala Val Leu Tyr Arg Xaa Leu Gly Leu Ile Leu Pro Pro 
        755                 760                 765             


Pro Arg Pro Pro Leu Ala Val Xaa Ser Arg Val Met Xaa Val Xaa Val 
    770                 775                 780                 


Arg Pro Pro Xaa Gln Pro Pro Ala Glu Pro Leu Ile Xaa Val Glu Leu 
785                 790                 795                 800 


Ser Tyr Ile Ile Asn Gly Xaa Xaa Asp Pro His Cys Ala Ser Trp Asp 
                805                 810                 815     


Tyr Ser Arg Ala Asp Ala Ser Ser Gly Asp Trp Asp Xaa Glu Asn Cys 
            820                 825                 830         


Gln Xaa Leu Glu Xaa Gln Ala Ala His Xaa Arg Cys Gln Cys Gln 
        835                 840                 845         


<210> 1617
<211> 1551
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1235)..(1235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1237)..(1237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1325)..(1325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1355)..(1355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1359)..(1359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1396)..(1396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1411)..(1411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1415)..(1415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1443)..(1443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1460)..(1460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1469)..(1469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1490)..(1490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1512)..(1512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1517)..(1517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1530)..(1530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1540)..(1540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1549)..(1549)
<223> Selenocysteine

<400> 1617
Met Glu Asn Xaa Gly Trp Met Gly Lys Gly His Arg Met Xaa Pro Ala 
1               5                   10                  15      


Cys Pro Leu Leu Leu Ser Val Ile Leu Ser Leu Arg Leu Ala Xaa Ala 
            20                  25                  30          


Phe Asp Pro Ala Pro Ser Ala Cys Ser Ala Leu Ala Ser Gly Val Leu 
        35                  40                  45              


Tyr Gly Ala Phe Ser Leu Gln Asp Leu Phe Pro Xaa Ile Ala Ser Gly 
    50                  55                  60                  


Cys Ser Trp Xaa Leu Glu Asn Pro Asp Pro Xaa Lys Tyr Ser Leu Tyr 
65                  70                  75                  80  


Leu Arg Phe Asn Arg Gln Glu Gln Val Cys Ala His Phe Ala Pro Arg 
                85                  90                  95      


Leu Leu Pro Leu Asp His Tyr Leu Val Asn Phe Xaa Cys Leu Arg Pro 
            100                 105                 110         


Ser Pro Glu Glu Ala Val Ala Gln Ala Glu Ser Glu Val Gly Arg Pro 
        115                 120                 125             


Glu Glu Glu Glu Ala Glu Ala Ala Ala Gly Leu Glu Leu Cys Ser Gly 
    130                 135                 140                 


Ser Gly Pro Phe Xaa Phe Leu His Phe Asp Lys Asn Phe Val Gln Leu 
145                 150                 155                 160 


Cys Leu Ser Ala Glu Pro Ser Glu Ala Pro Arg Leu Leu Ala Pro Ala 
                165                 170                 175     


Ala Leu Ala Phe Arg Phe Val Glu Val Leu Leu Ile Asn Asn Asn Asn 
            180                 185                 190         


Ser Ser Gln Phe Xaa Cys Gly Val Leu Cys Arg Trp Ser Glu Glu Cys 
        195                 200                 205             


Gly Arg Ala Ala Gly Arg Ala Cys Gly Phe Ala Gln Pro Gly Cys Ser 
    210                 215                 220                 


Cys Pro Gly Glu Ala Gly Ala Gly Ser Xaa Xaa Xaa Xaa Ser Pro Gly 
225                 230                 235                 240 


Pro Pro Ala Ala His Xaa Leu Ser Asn Ala Leu Val Pro Gly Gly Pro 
                245                 250                 255     


Ala Pro Pro Ala Glu Ala Asp Leu His Ser Gly Ser Ser Asn Asp Leu 
            260                 265                 270         


Phe Xaa Xaa Glu Met Arg Tyr Gly Glu Glu Pro Glu Glu Glu Pro Lys 
        275                 280                 285             


Val Lys Xaa Gln Trp Pro Arg Ser Ala Asp Glu Pro Gly Leu Tyr Met 
    290                 295                 300                 


Ala Gln Xaa Gly Asp Pro Ala Ala Glu Glu Trp Ser Pro Trp Ser Val 
305                 310                 315                 320 


Cys Ser Leu Xaa Cys Gly Gln Gly Leu Gln Val Arg Xaa Arg Ser Cys 
                325                 330                 335     


Val Ser Ser Pro Tyr Gly Xaa Leu Cys Ser Gly Pro Leu Arg Glu Xaa 
            340                 345                 350         


Arg Pro Cys Asn Asn Ser Ala Xaa Cys Pro Val His Gly Val Trp Glu 
        355                 360                 365             


Glu Trp Gly Ser Trp Ser Leu Cys Ser Arg Ser Cys Gly Arg Gly Ser 
    370                 375                 380                 


Arg Ser Arg Met Arg Xaa Cys Val Pro Pro Gln His Gly Gly Lys Ala 
385                 390                 395                 400 


Cys Glu Gly Pro Glu Leu Gln Xaa Lys Leu Cys Ser Met Ala Ala Cys 
                405                 410                 415     


Pro Val Glu Gly Gln Trp Leu Glu Trp Gly Pro Trp Gly Pro Cys Ser 
            420                 425                 430         


Xaa Ser Cys Ala Asn Gly Xaa Gln Gln Arg Ser Arg Lys Cys Ser Val 
        435                 440                 445             


Ala Gly Pro Ala Trp Ala Xaa Cys Xaa Gly Ala Leu Xaa Asp Xaa Arg 
    450                 455                 460                 


Glu Cys Ser Asn Leu Glu Cys Pro Ala Xaa Asp Ser Lys Trp Gly Pro 
465                 470                 475                 480 


Trp Asn Ala Trp Ser Leu Cys Ser Lys Xaa Cys Asp Xaa Gly Trp Gln 
                485                 490                 495     


Arg Arg Phe Arg Met Cys Gln Ala Xaa Gly Xaa Gln Gly Tyr Pro Cys 
            500                 505                 510         


Glu Gly Xaa Gly Glu Glu Val Lys Pro Cys Ser Glu Lys Arg Cys Pro 
        515                 520                 525             


Ala Phe His Glu Met Cys Arg Asp Glu Tyr Val Met Leu Met Xaa Trp 
    530                 535                 540                 


Lys Lys Ala Ala Ala Gly Glu Ile Ile Tyr Asn Lys Cys Pro Pro Asn 
545                 550                 555                 560 


Ala Ser Gly Ser Ala Ser Arg Arg Cys Leu Leu Ser Ala Gln Gly Val 
                565                 570                 575     


Ala Tyr Trp Gly Leu Pro Ser Phe Ala Arg Cys Ile Ser His Glu Tyr 
            580                 585                 590         


Arg Tyr Leu Tyr Leu Ser Leu Arg Glu His Leu Ala Lys Gly Gln Arg 
        595                 600                 605             


Met Leu Ala Gly Glu Gly Met Ser Gln Val Val Arg Ser Leu Gln Glu 
    610                 615                 620                 


Leu Leu Ala Arg Arg Xaa Tyr Tyr Ser Gly Asp Leu Leu Phe Ser Val 
625                 630                 635                 640 


Asp Ile Leu Arg Asn Val Xaa Asp Xaa Phe Lys Arg Ala Xaa Tyr Val 
                645                 650                 655     


Pro Ser Ala Asp Asp Val Gln Arg Phe Phe Gln Val Val Ser Phe Met 
            660                 665                 670         


Val Asp Ala Glu Asn Lys Glu Lys Trp Asp Asp Ala Gln Gln Val Ser 
        675                 680                 685             


Pro Gly Ser Val His Leu Leu Arg Val Val Glu Asp Phe Ile His Leu 
    690                 695                 700                 


Val Gly Asp Ala Leu Lys Ala Phe Gln Ser Ser Leu Ile Val Xaa Asp 
705                 710                 715                 720 


Asn Leu Val Ile Ser Ile Gln Arg Glu Pro Val Ser Ala Val Ser Ser 
                725                 730                 735     


Asp Ile Xaa Phe Pro Met Arg Gly Arg Arg Gly Met Lys Asp Trp Val 
            740                 745                 750         


Arg His Ser Glu Asp Arg Leu Phe Leu Pro Lys Glu Val Leu Ser Leu 
        755                 760                 765             


Ser Ser Pro Gly Lys Pro Ala Xaa Ser Gly Ala Ala Gly Ser Pro Gly 
    770                 775                 780                 


Arg Gly Arg Gly Pro Gly Xaa Val Pro Pro Gly Pro Gly His Ser His 
785                 790                 795                 800 


Gln Arg Leu Leu Pro Ala Asp Pro Asp Glu Ser Ser Tyr Phe Val Ile 
                805                 810                 815     


Gly Ala Val Leu Tyr Arg Xaa Leu Gly Leu Ile Leu Pro Pro Pro Arg 
            820                 825                 830         


Pro Pro Leu Ala Val Xaa Ser Arg Val Met Xaa Val Xaa Val Arg Pro 
        835                 840                 845             


Pro Xaa Gln Pro Pro Ala Glu Pro Leu Ile Xaa Val Glu Leu Ser Tyr 
    850                 855                 860                 


Ile Ile Asn Gly Xaa Xaa Asp Pro His Cys Ala Ser Trp Asp Tyr Ser 
865                 870                 875                 880 


Arg Ala Asp Ala Ser Ser Gly Asp Trp Asp Xaa Glu Asn Cys Gln Xaa 
                885                 890                 895     


Leu Glu Xaa Gln Ala Ala His Xaa Arg Cys Gln Cys Gln His Leu Ser 
            900                 905                 910         


Xaa Phe Ala Val Leu Ala Gln Pro Pro Lys Asp Leu Xaa Leu Glu Leu 
        915                 920                 925             


Ala Gly Ser Pro Ser Val Pro Leu Val Ile Gly Cys Ala Val Ser Cys 
    930                 935                 940                 


Met Ala Leu Leu Xaa Leu Leu Ala Ile Tyr Ala Ala Phe Trp Arg Phe 
945                 950                 955                 960 


Ile Lys Ser Glu Arg Ser Ile Ile Leu Leu Asn Phe Cys Leu Ser Ile 
                965                 970                 975     


Leu Ala Ser Asn Ile Leu Ile Leu Val Gly Gln Ser Arg Val Leu Ser 
            980                 985                 990         


Lys Gly Val Cys Xaa Met Xaa Ala  Ala Phe Leu His Phe  Phe Phe Leu 
        995                 1000                 1005             


Ser Ser  Phe Cys Trp Val Leu  Xaa Glu Ala Trp Gln  Ser Tyr Leu 
    1010                 1015                 1020             


Ala Val  Ile Gly Arg Met Arg  Xaa Arg Leu Val Arg  Lys Arg Phe 
    1025                 1030                 1035             


Leu Cys  Leu Gly Trp Gly Leu  Pro Ala Leu Val Val  Ala Val Ser 
    1040                 1045                 1050             


Val Gly  Phe Xaa Arg Xaa Lys  Gly Tyr Gly Xaa Ser  Ser Tyr Cys 
    1055                 1060                 1065             


Trp Leu  Ser Leu Glu Gly Gly  Leu Leu Tyr Ala Phe  Val Gly Pro 
    1070                 1075                 1080             


Ala Ala  Val Ile Val Leu Val  Asn Met Leu Ile Gly  Ile Ile Val 
    1085                 1090                 1095             


Phe Asn  Lys Leu Met Ala Arg  Asp Gly Ile Ser Asp  Lys Ser Lys 
    1100                 1105                 1110             


Lys Gln  Arg Ala Gly Ala Ser  Leu Trp Ser Ser Cys  Val Val Leu 
    1115                 1120                 1125             


Pro Leu  Leu Ala Leu Xaa Trp  Met Ser Ala Val Leu  Ala Met Xaa 
    1130                 1135                 1140             


Asp Arg  Arg Ser Val Leu Phe  Gln Ala Leu Phe Ala  Val Phe Asn 
    1145                 1150                 1155             


Ser Ala  Gln Gly Phe Val Ile  Xaa Ala Val His Cys  Phe Leu Arg 
    1160                 1165                 1170             


Arg Glu  Val Gln Asp Val Val  Lys Cys Gln Met Gly  Val Cys Arg 
    1175                 1180                 1185             


Ala Asp  Glu Ser Glu Asp Ser  Pro Asp Ser Cys Lys  Asn Gly Gln 
    1190                 1195                 1200             


Leu Gln  Ile Leu Ser Asp Phe  Glu Lys Asp Val Asp  Leu Ala Cys 
    1205                 1210                 1215             


Gln Xaa  Val Leu Phe Lys Glu  Val Asn Xaa Cys Asn  Pro Ser Xaa 
    1220                 1225                 1230             


Ile Xaa  Gly Xaa Leu Ser Arg  Leu Ser Leu Asp Glu  Asp Glu Glu 
    1235                 1240                 1245             


Pro Lys  Ser Cys Leu Val Gly  Pro Glu Gly Ser Leu  Ser Phe Ser 
    1250                 1255                 1260             


Pro Leu  Pro Gly Asn Ile Leu  Val Pro Met Ala Ala  Ser Pro Gly 
    1265                 1270                 1275             


Leu Gly  Glu Pro Pro Pro Pro  Gln Glu Ala Asn Pro  Val Tyr Met 
    1280                 1285                 1290             


Cys Gly  Glu Gly Gly Leu Arg  Gln Leu Asp Leu Xaa  Trp Leu Arg 
    1295                 1300                 1305             


Pro Xaa  Glu Pro Gly Ser Glu  Gly Asp Tyr Met Val  Leu Pro Arg 
    1310                 1315                 1320             


Arg Xaa  Leu Ser Leu Gln Pro  Gly Gly Gly Gly Gly  Gly Gly Glu 
    1325                 1330                 1335             


Asp Ala  Pro Arg Ala Arg Pro  Glu Gly Xaa Pro Arg  Arg Ala Ala 
    1340                 1345                 1350             


Lys Xaa  Val Ala His Xaa Glu  Gly Tyr Pro Ser Phe  Leu Ser Val 
    1355                 1360                 1365             


Asp His  Ser Gly Leu Gly Leu  Gly Pro Ala Tyr Gly  Ser Leu Gln 
    1370                 1375                 1380             


Asn Pro  Tyr Gly Met Xaa Phe  Gln Pro Pro Pro Pro  Xaa Pro Ser 
    1385                 1390                 1395             


Ala Arg  Gln Val Pro Glu Pro  Gly Glu Arg Ser Arg  Xaa Met Pro 
    1400                 1405                 1410             


Arg Xaa  Val Pro Gly Ser Xaa  Met Lys Met Gly Ser  Leu Glu Arg 
    1415                 1420                 1425             


Lys Lys  Leu Arg Tyr Ser Asp  Leu Asp Phe Glu Val  Met His Xaa 
    1430                 1435                 1440             


Arg Lys  Arg His Ser Glu Leu  Tyr His Glu Leu Asn  Gln Lys Phe 
    1445                 1450                 1455             


His Xaa  Phe Asp Arg Tyr Arg  Ser Gln Ser Xaa Ala  Lys Arg Glu 
    1460                 1465                 1470             


Lys Arg  Trp Ser Val Ser Ser  Gly Gly Ala Ala Glu  Arg Ser Val 
    1475                 1480                 1485             


Cys Xaa  Asp Lys Pro Ser Pro  Gly Glu Arg Pro Ser  Leu Ser Gln 
    1490                 1495                 1500             


His Arg  Arg His Gln Ser Trp  Ser Xaa Phe Lys Ser  Met Xaa Leu 
    1505                 1510                 1515             


Gly Ser  Leu Pro Pro Lys Pro  Arg Glu Arg Leu Xaa  Leu His Arg 
    1520                 1525                 1530             


Ala Ala  Ala Trp Glu Pro Xaa  Glu Pro Pro Asp Gly  Asp Phe Gln 
    1535                 1540                 1545             


Xaa Glu  Val 
    1550     


<210> 1618
<211> 1584
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1176)..(1176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1253)..(1253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1268)..(1268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1270)..(1270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1338)..(1338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1343)..(1343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1388)..(1388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1392)..(1392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1422)..(1422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1429)..(1429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1444)..(1444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1448)..(1448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1453)..(1453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1476)..(1476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1493)..(1493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1502)..(1502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1523)..(1523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1550)..(1550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1563)..(1563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<400> 1618
Met Glu Asn Xaa Gly Trp Met Gly Lys Gly His Arg Met Xaa Pro Ala 
1               5                   10                  15      


Cys Pro Leu Leu Leu Ser Val Ile Leu Ser Leu Arg Leu Ala Xaa Ala 
            20                  25                  30          


Phe Asp Pro Ala Pro Ser Ala Cys Ser Ala Leu Ala Ser Gly Val Leu 
        35                  40                  45              


Tyr Gly Ala Phe Ser Leu Gln Asp Leu Phe Pro Xaa Ile Ala Ser Gly 
    50                  55                  60                  


Cys Ser Trp Xaa Leu Glu Asn Pro Asp Pro Xaa Lys Tyr Ser Leu Tyr 
65                  70                  75                  80  


Leu Arg Phe Asn Arg Gln Glu Gln Val Cys Ala His Phe Ala Pro Arg 
                85                  90                  95      


Leu Leu Pro Leu Asp His Tyr Leu Val Asn Phe Xaa Cys Leu Arg Pro 
            100                 105                 110         


Ser Pro Glu Glu Ala Val Ala Gln Ala Glu Ser Glu Val Gly Arg Pro 
        115                 120                 125             


Glu Glu Glu Glu Ala Glu Ala Ala Ala Gly Leu Glu Leu Cys Ser Gly 
    130                 135                 140                 


Ser Gly Pro Phe Xaa Phe Leu His Phe Asp Lys Asn Phe Val Gln Leu 
145                 150                 155                 160 


Cys Leu Ser Ala Glu Pro Ser Glu Ala Pro Arg Leu Leu Ala Pro Ala 
                165                 170                 175     


Ala Leu Ala Phe Arg Phe Val Glu Val Leu Leu Ile Asn Asn Asn Asn 
            180                 185                 190         


Ser Ser Gln Phe Xaa Cys Gly Val Leu Cys Arg Trp Ser Glu Glu Cys 
        195                 200                 205             


Gly Arg Ala Ala Gly Arg Ala Cys Gly Phe Ala Gln Pro Gly Cys Ser 
    210                 215                 220                 


Cys Pro Gly Glu Ala Gly Ala Gly Ser Xaa Xaa Xaa Xaa Ser Pro Gly 
225                 230                 235                 240 


Pro Pro Ala Ala His Xaa Leu Ser Asn Ala Leu Val Pro Gly Gly Pro 
                245                 250                 255     


Ala Pro Pro Ala Glu Ala Asp Leu His Ser Gly Ser Ser Asn Asp Leu 
            260                 265                 270         


Phe Xaa Xaa Glu Met Arg Tyr Gly Glu Glu Pro Glu Glu Glu Pro Lys 
        275                 280                 285             


Val Lys Xaa Gln Trp Pro Arg Ser Ala Asp Glu Pro Gly Leu Tyr Met 
    290                 295                 300                 


Ala Gln Xaa Gly Asp Pro Ala Ala Glu Glu Trp Ser Pro Trp Ser Val 
305                 310                 315                 320 


Cys Ser Leu Xaa Cys Gly Gln Gly Leu Gln Val Arg Xaa Arg Ser Cys 
                325                 330                 335     


Val Ser Ser Pro Tyr Gly Xaa Leu Cys Ser Gly Pro Leu Arg Glu Xaa 
            340                 345                 350         


Arg Pro Cys Asn Asn Ser Ala Xaa Cys Pro Val His Gly Val Trp Glu 
        355                 360                 365             


Glu Trp Gly Ser Trp Ser Leu Cys Ser Arg Ser Cys Gly Arg Gly Ser 
    370                 375                 380                 


Arg Ser Arg Met Arg Xaa Cys Val Pro Pro Gln His Gly Gly Lys Ala 
385                 390                 395                 400 


Cys Glu Gly Pro Glu Leu Gln Xaa Lys Leu Cys Ser Met Ala Ala Cys 
                405                 410                 415     


Pro Val Glu Gly Gln Trp Leu Glu Trp Gly Pro Trp Gly Pro Cys Ser 
            420                 425                 430         


Xaa Ser Cys Ala Asn Gly Xaa Gln Gln Arg Ser Arg Lys Cys Ser Val 
        435                 440                 445             


Ala Gly Pro Ala Trp Ala Xaa Cys Xaa Gly Ala Leu Xaa Asp Xaa Arg 
    450                 455                 460                 


Glu Cys Ser Asn Leu Glu Cys Pro Ala Xaa Asp Ser Lys Trp Gly Pro 
465                 470                 475                 480 


Trp Asn Ala Trp Ser Leu Cys Ser Lys Xaa Cys Asp Xaa Gly Trp Gln 
                485                 490                 495     


Arg Arg Phe Arg Met Cys Gln Ala Xaa Gly Xaa Gln Gly Tyr Pro Cys 
            500                 505                 510         


Glu Gly Xaa Gly Glu Glu Val Lys Pro Cys Ser Glu Lys Arg Cys Pro 
        515                 520                 525             


Ala Phe His Glu Met Cys Arg Asp Glu Tyr Val Met Leu Met Xaa Trp 
    530                 535                 540                 


Lys Lys Ala Ala Ala Gly Glu Ile Ile Tyr Asn Lys Cys Pro Pro Asn 
545                 550                 555                 560 


Ala Ser Gly Ser Ala Ser Arg Arg Cys Leu Leu Ser Ala Gln Gly Val 
                565                 570                 575     


Ala Tyr Trp Gly Leu Pro Ser Phe Ala Arg Cys Ile Ser His Glu Tyr 
            580                 585                 590         


Arg Tyr Leu Tyr Leu Ser Leu Arg Glu His Leu Ala Lys Gly Gln Arg 
        595                 600                 605             


Met Leu Ala Gly Glu Gly Met Ser Gln Val Val Arg Ser Leu Gln Glu 
    610                 615                 620                 


Leu Leu Ala Arg Arg Xaa Tyr Tyr Ser Gly Asp Leu Leu Phe Ser Val 
625                 630                 635                 640 


Asp Ile Leu Arg Asn Val Xaa Asp Xaa Phe Lys Arg Ala Xaa Tyr Val 
                645                 650                 655     


Pro Ser Ala Asp Asp Val Gln Arg Phe Phe Gln Val Val Ser Phe Met 
            660                 665                 670         


Val Asp Ala Glu Asn Lys Glu Lys Trp Asp Asp Ala Gln Gln Val Ser 
        675                 680                 685             


Pro Gly Ser Val His Leu Leu Arg Val Val Glu Asp Phe Ile His Leu 
    690                 695                 700                 


Val Gly Asp Ala Leu Lys Ala Phe Gln Ser Ser Leu Ile Val Xaa Asp 
705                 710                 715                 720 


Asn Leu Val Ile Ser Ile Gln Arg Glu Pro Val Ser Ala Val Ser Ser 
                725                 730                 735     


Asp Ile Xaa Phe Pro Met Arg Gly Arg Arg Gly Met Lys Asp Trp Val 
            740                 745                 750         


Arg His Ser Glu Asp Arg Leu Phe Leu Pro Lys Glu Val Leu Ser Leu 
        755                 760                 765             


Ser Ser Pro Gly Lys Pro Ala Xaa Ser Gly Ala Ala Gly Ser Pro Gly 
    770                 775                 780                 


Arg Gly Arg Gly Pro Gly Xaa Val Pro Pro Gly Pro Gly His Ser His 
785                 790                 795                 800 


Gln Arg Leu Leu Pro Ala Asp Pro Asp Glu Ser Ser Tyr Phe Val Ile 
                805                 810                 815     


Gly Ala Val Leu Tyr Arg Xaa Leu Gly Leu Ile Leu Pro Pro Pro Arg 
            820                 825                 830         


Pro Pro Leu Ala Val Xaa Ser Arg Val Met Xaa Val Xaa Val Arg Pro 
        835                 840                 845             


Pro Xaa Gln Pro Pro Ala Glu Pro Leu Ile Xaa Val Glu Leu Ser Tyr 
    850                 855                 860                 


Ile Ile Asn Gly Xaa Xaa Asp Pro His Cys Ala Ser Trp Asp Tyr Ser 
865                 870                 875                 880 


Arg Ala Asp Ala Ser Ser Gly Asp Trp Asp Xaa Glu Asn Cys Gln Xaa 
                885                 890                 895     


Leu Glu Xaa Gln Ala Ala His Xaa Arg Cys Gln Cys Gln His Leu Ser 
            900                 905                 910         


Xaa Phe Ala Val Leu Ala Gln Pro Pro Lys Asp Leu Xaa Leu Glu Leu 
        915                 920                 925             


Ala Gly Ser Pro Ser Val Pro Leu Val Ile Gly Cys Ala Val Ser Cys 
    930                 935                 940                 


Met Ala Leu Leu Xaa Leu Leu Ala Ile Tyr Ala Ala Phe Trp Arg Phe 
945                 950                 955                 960 


Ile Lys Ser Glu Arg Ser Ile Ile Leu Leu Asn Phe Cys Leu Ser Ile 
                965                 970                 975     


Leu Ala Ser Asn Ile Leu Ile Leu Val Gly Gln Ser Arg Val Leu Ser 
            980                 985                 990         


Lys Gly Val Cys Xaa Met Xaa Ala  Ala Phe Leu His Phe  Phe Phe Leu 
        995                 1000                 1005             


Ser Ser  Phe Cys Trp Val Leu  Xaa Glu Ala Trp Gln  Ser Tyr Leu 
    1010                 1015                 1020             


Ala Val  Ile Gly Arg Met Arg  Xaa Arg Leu Val Arg  Lys Arg Phe 
    1025                 1030                 1035             


Leu Cys  Leu Gly Trp Gly Leu  Pro Ala Leu Val Val  Ala Val Ser 
    1040                 1045                 1050             


Val Gly  Phe Xaa Arg Xaa Lys  Gly Tyr Gly Xaa Ser  Ser Tyr Cys 
    1055                 1060                 1065             


Trp Leu  Ser Leu Glu Gly Gly  Leu Leu Tyr Ala Phe  Val Gly Pro 
    1070                 1075                 1080             


Ala Ala  Val Ile Val Leu Val  Asn Met Leu Ile Gly  Ile Ile Val 
    1085                 1090                 1095             


Phe Asn  Lys Leu Met Ala Arg  Asp Gly Ile Ser Asp  Lys Ser Lys 
    1100                 1105                 1110             


Lys Gln  Arg Ala Gly Ser Glu  Arg Cys Pro Trp Ala  Ser Leu Leu 
    1115                 1120                 1125             


Leu Pro  Cys Ser Ala Cys Gly  Ala Val Pro Ser Pro  Leu Leu Ser 
    1130                 1135                 1140             


Ser Ala  Ser Ala Arg Asn Ala  Met Ala Ser Leu Trp  Ser Ser Cys 
    1145                 1150                 1155             


Val Val  Leu Pro Leu Leu Ala  Leu Xaa Trp Met Ser  Ala Val Leu 
    1160                 1165                 1170             


Ala Met  Xaa Asp Arg Arg Ser  Val Leu Phe Gln Ala  Leu Phe Ala 
    1175                 1180                 1185             


Val Phe  Asn Ser Ala Gln Gly  Phe Val Ile Xaa Ala  Val His Cys 
    1190                 1195                 1200             


Phe Leu  Arg Arg Glu Val Gln  Asp Val Val Lys Cys  Gln Met Gly 
    1205                 1210                 1215             


Val Cys  Arg Ala Asp Glu Ser  Glu Asp Ser Pro Asp  Ser Cys Lys 
    1220                 1225                 1230             


Asn Gly  Gln Leu Gln Ile Leu  Ser Asp Phe Glu Lys  Asp Val Asp 
    1235                 1240                 1245             


Leu Ala  Cys Gln Xaa Val Leu  Phe Lys Glu Val Asn  Xaa Cys Asn 
    1250                 1255                 1260             


Pro Ser  Xaa Ile Xaa Gly Xaa  Leu Ser Arg Leu Ser  Leu Asp Glu 
    1265                 1270                 1275             


Asp Glu  Glu Pro Lys Ser Cys  Leu Val Gly Pro Glu  Gly Ser Leu 
    1280                 1285                 1290             


Ser Phe  Ser Pro Leu Pro Gly  Asn Ile Leu Val Pro  Met Ala Ala 
    1295                 1300                 1305             


Ser Pro  Gly Leu Gly Glu Pro  Pro Pro Pro Gln Glu  Ala Asn Pro 
    1310                 1315                 1320             


Val Tyr  Met Cys Gly Glu Gly  Gly Leu Arg Gln Leu  Asp Leu Xaa 
    1325                 1330                 1335             


Trp Leu  Arg Pro Xaa Glu Pro  Gly Ser Glu Gly Asp  Tyr Met Val 
    1340                 1345                 1350             


Leu Pro  Arg Arg Xaa Leu Ser  Leu Gln Pro Gly Gly  Gly Gly Gly 
    1355                 1360                 1365             


Gly Gly  Glu Asp Ala Pro Arg  Ala Arg Pro Glu Gly  Xaa Pro Arg 
    1370                 1375                 1380             


Arg Ala  Ala Lys Xaa Val Ala  His Xaa Glu Gly Tyr  Pro Ser Phe 
    1385                 1390                 1395             


Leu Ser  Val Asp His Ser Gly  Leu Gly Leu Gly Pro  Ala Tyr Gly 
    1400                 1405                 1410             


Ser Leu  Gln Asn Pro Tyr Gly  Met Xaa Phe Gln Pro  Pro Pro Pro 
    1415                 1420                 1425             


Xaa Pro  Ser Ala Arg Gln Val  Pro Glu Pro Gly Glu  Arg Ser Arg 
    1430                 1435                 1440             


Xaa Met  Pro Arg Xaa Val Pro  Gly Ser Xaa Met Lys  Met Gly Ser 
    1445                 1450                 1455             


Leu Glu  Arg Lys Lys Leu Arg  Tyr Ser Asp Leu Asp  Phe Glu Val 
    1460                 1465                 1470             


Met His  Xaa Arg Lys Arg His  Ser Glu Leu Tyr His  Glu Leu Asn 
    1475                 1480                 1485             


Gln Lys  Phe His Xaa Phe Asp  Arg Tyr Arg Ser Gln  Ser Xaa Ala 
    1490                 1495                 1500             


Lys Arg  Glu Lys Arg Trp Ser  Val Ser Ser Gly Gly  Ala Ala Glu 
    1505                 1510                 1515             


Arg Ser  Val Cys Xaa Asp Lys  Pro Ser Pro Gly Glu  Arg Pro Ser 
    1520                 1525                 1530             


Leu Ser  Gln His Arg Arg His  Gln Ser Trp Ser Xaa  Phe Lys Ser 
    1535                 1540                 1545             


Met Xaa  Leu Gly Ser Leu Pro  Pro Lys Pro Arg Glu  Arg Leu Xaa 
    1550                 1555                 1560             


Leu His  Arg Ala Ala Ala Trp  Glu Pro Xaa Glu Pro  Pro Asp Gly 
    1565                 1570                 1575             


Asp Phe  Gln Xaa Glu Val 
    1580                 


<210> 1619
<211> 1585
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1176)..(1176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1253)..(1253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1268)..(1268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1270)..(1270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1338)..(1338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1343)..(1343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1388)..(1388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1392)..(1392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1422)..(1422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1429)..(1429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1444)..(1444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1448)..(1448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1453)..(1453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1477)..(1477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1494)..(1494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1503)..(1503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1524)..(1524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1546)..(1546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1551)..(1551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1564)..(1564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1583)..(1583)
<223> Selenocysteine

<400> 1619
Met Glu Asn Xaa Gly Trp Met Gly Lys Gly His Arg Met Xaa Pro Ala 
1               5                   10                  15      


Cys Pro Leu Leu Leu Ser Val Ile Leu Ser Leu Arg Leu Ala Xaa Ala 
            20                  25                  30          


Phe Asp Pro Ala Pro Ser Ala Cys Ser Ala Leu Ala Ser Gly Val Leu 
        35                  40                  45              


Tyr Gly Ala Phe Ser Leu Gln Asp Leu Phe Pro Xaa Ile Ala Ser Gly 
    50                  55                  60                  


Cys Ser Trp Xaa Leu Glu Asn Pro Asp Pro Xaa Lys Tyr Ser Leu Tyr 
65                  70                  75                  80  


Leu Arg Phe Asn Arg Gln Glu Gln Val Cys Ala His Phe Ala Pro Arg 
                85                  90                  95      


Leu Leu Pro Leu Asp His Tyr Leu Val Asn Phe Xaa Cys Leu Arg Pro 
            100                 105                 110         


Ser Pro Glu Glu Ala Val Ala Gln Ala Glu Ser Glu Val Gly Arg Pro 
        115                 120                 125             


Glu Glu Glu Glu Ala Glu Ala Ala Ala Gly Leu Glu Leu Cys Ser Gly 
    130                 135                 140                 


Ser Gly Pro Phe Xaa Phe Leu His Phe Asp Lys Asn Phe Val Gln Leu 
145                 150                 155                 160 


Cys Leu Ser Ala Glu Pro Ser Glu Ala Pro Arg Leu Leu Ala Pro Ala 
                165                 170                 175     


Ala Leu Ala Phe Arg Phe Val Glu Val Leu Leu Ile Asn Asn Asn Asn 
            180                 185                 190         


Ser Ser Gln Phe Xaa Cys Gly Val Leu Cys Arg Trp Ser Glu Glu Cys 
        195                 200                 205             


Gly Arg Ala Ala Gly Arg Ala Cys Gly Phe Ala Gln Pro Gly Cys Ser 
    210                 215                 220                 


Cys Pro Gly Glu Ala Gly Ala Gly Ser Xaa Xaa Xaa Xaa Ser Pro Gly 
225                 230                 235                 240 


Pro Pro Ala Ala His Xaa Leu Ser Asn Ala Leu Val Pro Gly Gly Pro 
                245                 250                 255     


Ala Pro Pro Ala Glu Ala Asp Leu His Ser Gly Ser Ser Asn Asp Leu 
            260                 265                 270         


Phe Xaa Xaa Glu Met Arg Tyr Gly Glu Glu Pro Glu Glu Glu Pro Lys 
        275                 280                 285             


Val Lys Xaa Gln Trp Pro Arg Ser Ala Asp Glu Pro Gly Leu Tyr Met 
    290                 295                 300                 


Ala Gln Xaa Gly Asp Pro Ala Ala Glu Glu Trp Ser Pro Trp Ser Val 
305                 310                 315                 320 


Cys Ser Leu Xaa Cys Gly Gln Gly Leu Gln Val Arg Xaa Arg Ser Cys 
                325                 330                 335     


Val Ser Ser Pro Tyr Gly Xaa Leu Cys Ser Gly Pro Leu Arg Glu Xaa 
            340                 345                 350         


Arg Pro Cys Asn Asn Ser Ala Xaa Cys Pro Val His Gly Val Trp Glu 
        355                 360                 365             


Glu Trp Gly Ser Trp Ser Leu Cys Ser Arg Ser Cys Gly Arg Gly Ser 
    370                 375                 380                 


Arg Ser Arg Met Arg Xaa Cys Val Pro Pro Gln His Gly Gly Lys Ala 
385                 390                 395                 400 


Cys Glu Gly Pro Glu Leu Gln Xaa Lys Leu Cys Ser Met Ala Ala Cys 
                405                 410                 415     


Pro Val Glu Gly Gln Trp Leu Glu Trp Gly Pro Trp Gly Pro Cys Ser 
            420                 425                 430         


Xaa Ser Cys Ala Asn Gly Xaa Gln Gln Arg Ser Arg Lys Cys Ser Val 
        435                 440                 445             


Ala Gly Pro Ala Trp Ala Xaa Cys Xaa Gly Ala Leu Xaa Asp Xaa Arg 
    450                 455                 460                 


Glu Cys Ser Asn Leu Glu Cys Pro Ala Xaa Asp Ser Lys Trp Gly Pro 
465                 470                 475                 480 


Trp Asn Ala Trp Ser Leu Cys Ser Lys Xaa Cys Asp Xaa Gly Trp Gln 
                485                 490                 495     


Arg Arg Phe Arg Met Cys Gln Ala Xaa Gly Xaa Gln Gly Tyr Pro Cys 
            500                 505                 510         


Glu Gly Xaa Gly Glu Glu Val Lys Pro Cys Ser Glu Lys Arg Cys Pro 
        515                 520                 525             


Ala Phe His Glu Met Cys Arg Asp Glu Tyr Val Met Leu Met Xaa Trp 
    530                 535                 540                 


Lys Lys Ala Ala Ala Gly Glu Ile Ile Tyr Asn Lys Cys Pro Pro Asn 
545                 550                 555                 560 


Ala Ser Gly Ser Ala Ser Arg Arg Cys Leu Leu Ser Ala Gln Gly Val 
                565                 570                 575     


Ala Tyr Trp Gly Leu Pro Ser Phe Ala Arg Cys Ile Ser His Glu Tyr 
            580                 585                 590         


Arg Tyr Leu Tyr Leu Ser Leu Arg Glu His Leu Ala Lys Gly Gln Arg 
        595                 600                 605             


Met Leu Ala Gly Glu Gly Met Ser Gln Val Val Arg Ser Leu Gln Glu 
    610                 615                 620                 


Leu Leu Ala Arg Arg Xaa Tyr Tyr Ser Gly Asp Leu Leu Phe Ser Val 
625                 630                 635                 640 


Asp Ile Leu Arg Asn Val Xaa Asp Xaa Phe Lys Arg Ala Xaa Tyr Val 
                645                 650                 655     


Pro Ser Ala Asp Asp Val Gln Arg Phe Phe Gln Val Val Ser Phe Met 
            660                 665                 670         


Val Asp Ala Glu Asn Lys Glu Lys Trp Asp Asp Ala Gln Gln Val Ser 
        675                 680                 685             


Pro Gly Ser Val His Leu Leu Arg Val Val Glu Asp Phe Ile His Leu 
    690                 695                 700                 


Val Gly Asp Ala Leu Lys Ala Phe Gln Ser Ser Leu Ile Val Xaa Asp 
705                 710                 715                 720 


Asn Leu Val Ile Ser Ile Gln Arg Glu Pro Val Ser Ala Val Ser Ser 
                725                 730                 735     


Asp Ile Xaa Phe Pro Met Arg Gly Arg Arg Gly Met Lys Asp Trp Val 
            740                 745                 750         


Arg His Ser Glu Asp Arg Leu Phe Leu Pro Lys Glu Val Leu Ser Leu 
        755                 760                 765             


Ser Ser Pro Gly Lys Pro Ala Xaa Ser Gly Ala Ala Gly Ser Pro Gly 
    770                 775                 780                 


Arg Gly Arg Gly Pro Gly Xaa Val Pro Pro Gly Pro Gly His Ser His 
785                 790                 795                 800 


Gln Arg Leu Leu Pro Ala Asp Pro Asp Glu Ser Ser Tyr Phe Val Ile 
                805                 810                 815     


Gly Ala Val Leu Tyr Arg Xaa Leu Gly Leu Ile Leu Pro Pro Pro Arg 
            820                 825                 830         


Pro Pro Leu Ala Val Xaa Ser Arg Val Met Xaa Val Xaa Val Arg Pro 
        835                 840                 845             


Pro Xaa Gln Pro Pro Ala Glu Pro Leu Ile Xaa Val Glu Leu Ser Tyr 
    850                 855                 860                 


Ile Ile Asn Gly Xaa Xaa Asp Pro His Cys Ala Ser Trp Asp Tyr Ser 
865                 870                 875                 880 


Arg Ala Asp Ala Ser Ser Gly Asp Trp Asp Xaa Glu Asn Cys Gln Xaa 
                885                 890                 895     


Leu Glu Xaa Gln Ala Ala His Xaa Arg Cys Gln Cys Gln His Leu Ser 
            900                 905                 910         


Xaa Phe Ala Val Leu Ala Gln Pro Pro Lys Asp Leu Xaa Leu Glu Leu 
        915                 920                 925             


Ala Gly Ser Pro Ser Val Pro Leu Val Ile Gly Cys Ala Val Ser Cys 
    930                 935                 940                 


Met Ala Leu Leu Xaa Leu Leu Ala Ile Tyr Ala Ala Phe Trp Arg Phe 
945                 950                 955                 960 


Ile Lys Ser Glu Arg Ser Ile Ile Leu Leu Asn Phe Cys Leu Ser Ile 
                965                 970                 975     


Leu Ala Ser Asn Ile Leu Ile Leu Val Gly Gln Ser Arg Val Leu Ser 
            980                 985                 990         


Lys Gly Val Cys Xaa Met Xaa Ala  Ala Phe Leu His Phe  Phe Phe Leu 
        995                 1000                 1005             


Ser Ser  Phe Cys Trp Val Leu  Xaa Glu Ala Trp Gln  Ser Tyr Leu 
    1010                 1015                 1020             


Ala Val  Ile Gly Arg Met Arg  Xaa Arg Leu Val Arg  Lys Arg Phe 
    1025                 1030                 1035             


Leu Cys  Leu Gly Trp Gly Leu  Pro Ala Leu Val Val  Ala Val Ser 
    1040                 1045                 1050             


Val Gly  Phe Xaa Arg Xaa Lys  Gly Tyr Gly Xaa Ser  Ser Tyr Cys 
    1055                 1060                 1065             


Trp Leu  Ser Leu Glu Gly Gly  Leu Leu Tyr Ala Phe  Val Gly Pro 
    1070                 1075                 1080             


Ala Ala  Val Ile Val Leu Val  Asn Met Leu Ile Gly  Ile Ile Val 
    1085                 1090                 1095             


Phe Asn  Lys Leu Met Ala Arg  Asp Gly Ile Ser Asp  Lys Ser Lys 
    1100                 1105                 1110             


Lys Gln  Arg Ala Gly Ser Glu  Arg Cys Pro Trp Ala  Ser Leu Leu 
    1115                 1120                 1125             


Leu Pro  Cys Ser Ala Cys Gly  Ala Val Pro Ser Pro  Leu Leu Ser 
    1130                 1135                 1140             


Ser Ala  Ser Ala Arg Asn Ala  Met Ala Ser Leu Trp  Ser Ser Cys 
    1145                 1150                 1155             


Val Val  Leu Pro Leu Leu Ala  Leu Xaa Trp Met Ser  Ala Val Leu 
    1160                 1165                 1170             


Ala Met  Xaa Asp Arg Arg Ser  Val Leu Phe Gln Ala  Leu Phe Ala 
    1175                 1180                 1185             


Val Phe  Asn Ser Ala Gln Gly  Phe Val Ile Xaa Ala  Val His Cys 
    1190                 1195                 1200             


Phe Leu  Arg Arg Glu Val Gln  Asp Val Val Lys Cys  Gln Met Gly 
    1205                 1210                 1215             


Val Cys  Arg Ala Asp Glu Ser  Glu Asp Ser Pro Asp  Ser Cys Lys 
    1220                 1225                 1230             


Asn Gly  Gln Leu Gln Ile Leu  Ser Asp Phe Glu Lys  Asp Val Asp 
    1235                 1240                 1245             


Leu Ala  Cys Gln Xaa Val Leu  Phe Lys Glu Val Asn  Xaa Cys Asn 
    1250                 1255                 1260             


Pro Ser  Xaa Ile Xaa Gly Xaa  Leu Ser Arg Leu Ser  Leu Asp Glu 
    1265                 1270                 1275             


Asp Glu  Glu Pro Lys Ser Cys  Leu Val Gly Pro Glu  Gly Ser Leu 
    1280                 1285                 1290             


Ser Phe  Ser Pro Leu Pro Gly  Asn Ile Leu Val Pro  Met Ala Ala 
    1295                 1300                 1305             


Ser Pro  Gly Leu Gly Glu Pro  Pro Pro Pro Gln Glu  Ala Asn Pro 
    1310                 1315                 1320             


Val Tyr  Met Cys Gly Glu Gly  Gly Leu Arg Gln Leu  Asp Leu Xaa 
    1325                 1330                 1335             


Trp Leu  Arg Pro Xaa Glu Pro  Gly Ser Glu Gly Asp  Tyr Met Val 
    1340                 1345                 1350             


Leu Pro  Arg Arg Xaa Leu Ser  Leu Gln Pro Gly Gly  Gly Gly Gly 
    1355                 1360                 1365             


Gly Gly  Glu Asp Ala Pro Arg  Ala Arg Pro Glu Gly  Xaa Pro Arg 
    1370                 1375                 1380             


Arg Ala  Ala Lys Xaa Val Ala  His Xaa Glu Gly Tyr  Pro Ser Phe 
    1385                 1390                 1395             


Leu Ser  Val Asp His Ser Gly  Leu Gly Leu Gly Pro  Ala Tyr Gly 
    1400                 1405                 1410             


Ser Leu  Gln Asn Pro Tyr Gly  Met Xaa Phe Gln Pro  Pro Pro Pro 
    1415                 1420                 1425             


Xaa Pro  Ser Ala Arg Gln Val  Pro Glu Pro Gly Glu  Arg Ser Arg 
    1430                 1435                 1440             


Xaa Met  Pro Arg Xaa Val Pro  Gly Ser Xaa Met Lys  Met Gly Ser 
    1445                 1450                 1455             


Leu Glu  Arg Lys Lys Leu Arg  Tyr Ser Asp Leu Asp  Phe Glu Lys 
    1460                 1465                 1470             


Val Met  His Xaa Arg Lys Arg  His Ser Glu Leu Tyr  His Glu Leu 
    1475                 1480                 1485             


Asn Gln  Lys Phe His Xaa Phe  Asp Arg Tyr Arg Ser  Gln Ser Xaa 
    1490                 1495                 1500             


Ala Lys  Arg Glu Lys Arg Trp  Ser Val Ser Ser Gly  Gly Ala Ala 
    1505                 1510                 1515             


Glu Arg  Ser Val Cys Xaa Asp  Lys Pro Ser Pro Gly  Glu Arg Pro 
    1520                 1525                 1530             


Ser Leu  Ser Gln His Arg Arg  His Gln Ser Trp Ser  Xaa Phe Lys 
    1535                 1540                 1545             


Ser Met  Xaa Leu Gly Ser Leu  Pro Pro Lys Pro Arg  Glu Arg Leu 
    1550                 1555                 1560             


Xaa Leu  His Arg Ala Ala Ala  Trp Glu Pro Xaa Glu  Pro Pro Asp 
    1565                 1570                 1575             


Gly Asp  Phe Gln Xaa Glu Val  
    1580                 1585 


<210> 1620
<211> 507
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<400> 1620
Met His Leu Pro Arg Gln His Gly Ser Ala His Leu Gly His Leu Tyr 
1               5                   10                  15      


Ala Tyr Ala Lys Phe Ser Ala His Asp Trp His Leu His Ala Gln Gly 
            20                  25                  30          


His Ala Ile Cys Asn Ala His Gly Lys Gly Lys Gly His Arg Met Xaa 
        35                  40                  45              


Pro Ala Cys Pro Leu Leu Leu Ser Val Ile Leu Ser Leu Arg Leu Ala 
    50                  55                  60                  


Xaa Ala Phe Asp Pro Ala Pro Ser Ala Cys Ser Ala Leu Ala Ser Gly 
65                  70                  75                  80  


Val Leu Tyr Gly Ala Phe Ser Leu Gln Asp Leu Phe Pro Xaa Ile Ala 
                85                  90                  95      


Ser Gly Cys Ser Trp Xaa Leu Glu Asn Pro Asp Pro Xaa Lys Tyr Ser 
            100                 105                 110         


Leu Tyr Leu Arg Phe Asn Arg Gln Glu Gln Val Cys Ala His Phe Ala 
        115                 120                 125             


Pro Arg Leu Leu Pro Leu Asp His Tyr Leu Val Asn Phe Xaa Cys Leu 
    130                 135                 140                 


Arg Pro Ser Pro Glu Glu Ala Val Ala Gln Ala Glu Ser Glu Val Gly 
145                 150                 155                 160 


Arg Pro Glu Glu Glu Glu Ala Glu Ala Ala Ala Gly Leu Glu Leu Cys 
                165                 170                 175     


Ser Gly Ser Gly Pro Phe Xaa Phe Leu His Phe Asp Lys Asn Phe Val 
            180                 185                 190         


Gln Leu Cys Leu Ser Ala Glu Pro Ser Glu Ala Pro Arg Leu Leu Ala 
        195                 200                 205             


Pro Ala Ala Leu Ala Phe Arg Phe Val Glu Val Leu Leu Ile Asn Asn 
    210                 215                 220                 


Asn Asn Ser Ser Gln Phe Xaa Cys Gly Val Leu Cys Arg Trp Ser Glu 
225                 230                 235                 240 


Glu Cys Gly Arg Ala Ala Gly Arg Ala Cys Gly Phe Ala Gln Pro Gly 
                245                 250                 255     


Cys Ser Cys Pro Gly Glu Ala Gly Ala Gly Ser Xaa Xaa Xaa Xaa Ser 
            260                 265                 270         


Pro Gly Pro Pro Ala Ala His Xaa Leu Ser Asn Ala Leu Val Pro Gly 
        275                 280                 285             


Gly Pro Ala Pro Pro Ala Glu Ala Asp Leu His Ser Gly Ser Ser Asn 
    290                 295                 300                 


Asp Leu Phe Xaa Xaa Glu Met Arg Tyr Gly Glu Glu Pro Glu Glu Glu 
305                 310                 315                 320 


Pro Lys Val Lys Xaa Gln Trp Pro Arg Ser Ala Asp Glu Pro Gly Leu 
                325                 330                 335     


Tyr Met Ala Gln Xaa Val His Gly Val Trp Glu Glu Trp Gly Ser Trp 
            340                 345                 350         


Ser Leu Cys Ser Arg Ser Cys Gly Arg Gly Ser Arg Ser Arg Met Arg 
        355                 360                 365             


Xaa Cys Val Pro Pro Gln His Gly Gly Lys Ala Cys Glu Gly Pro Glu 
    370                 375                 380                 


Leu Gln Xaa Lys Leu Cys Ser Met Ala Ala Cys Pro Val Glu Gly Gln 
385                 390                 395                 400 


Trp Leu Glu Trp Gly Pro Trp Gly Pro Cys Ser Xaa Ser Cys Ala Asn 
                405                 410                 415     


Gly Xaa Gln Gln Arg Ser Arg Lys Cys Ser Val Ala Gly Pro Ala Trp 
            420                 425                 430         


Ala Xaa Cys Xaa Gly Ala Leu Xaa Asp Xaa Arg Glu Cys Ser Asn Leu 
        435                 440                 445             


Glu Cys Pro Ala Xaa Asp Ser Lys Trp Gly Pro Trp Asn Ala Trp Ser 
    450                 455                 460                 


Leu Cys Ser Lys Xaa Cys Asp Xaa Gly Trp Gln Arg Arg Phe Arg Met 
465                 470                 475                 480 


Cys Gln Ala Xaa Gly Xaa Gln Gly Tyr Pro Cys Glu Gly Xaa Gly Glu 
                485                 490                 495     


Glu Val Lys Pro Cys Ser Glu Lys Arg Cys Pro 
            500                 505         


<210> 1621
<211> 1500
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (873)..(873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1007)..(1007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1091)..(1091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1176)..(1176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1253)..(1253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1273)..(1273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1296)..(1296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1344)..(1344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1359)..(1359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1363)..(1363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1368)..(1368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1392)..(1392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1409)..(1409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1418)..(1418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1439)..(1439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1461)..(1461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1466)..(1466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1479)..(1479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1489)..(1489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1498)..(1498)
<223> Selenocysteine

<400> 1621
Met Leu Ser Leu Arg Gly Pro Asp Xaa His Gly Lys Gly His Arg Met 
1               5                   10                  15      


Xaa Pro Ala Cys Pro Leu Leu Leu Ser Val Ile Leu Ser Leu Arg Leu 
            20                  25                  30          


Ala Xaa Ala Phe Asp Pro Ala Pro Ser Ala Cys Ser Ala Leu Ala Ser 
        35                  40                  45              


Gly Val Leu Tyr Gly Ala Phe Ser Leu Gln Asp Leu Phe Pro Xaa Ile 
    50                  55                  60                  


Ala Ser Gly Cys Ser Trp Xaa Leu Glu Asn Pro Asp Pro Xaa Lys Tyr 
65                  70                  75                  80  


Ser Leu Tyr Leu Arg Phe Asn Arg Gln Glu Gln Val Cys Ala His Phe 
                85                  90                  95      


Ala Pro Arg Leu Leu Pro Leu Asp His Tyr Leu Val Asn Phe Xaa Cys 
            100                 105                 110         


Leu Arg Pro Ser Pro Glu Glu Ala Val Ala Gln Ala Glu Ser Glu Val 
        115                 120                 125             


Gly Arg Pro Glu Glu Glu Glu Ala Glu Ala Ala Ala Gly Leu Glu Leu 
    130                 135                 140                 


Cys Ser Gly Ser Gly Pro Phe Xaa Phe Leu His Phe Asp Lys Asn Phe 
145                 150                 155                 160 


Val Gln Leu Cys Leu Ser Ala Glu Pro Ser Glu Ala Pro Arg Leu Leu 
                165                 170                 175     


Ala Pro Ala Ala Leu Ala Phe Arg Phe Val Glu Val Leu Leu Ile Asn 
            180                 185                 190         


Asn Asn Asn Ser Ser Gln Phe Xaa Cys Gly Val Leu Cys Arg Trp Ser 
        195                 200                 205             


Glu Glu Cys Gly Arg Ala Ala Gly Arg Ala Cys Gly Phe Ala Gln Pro 
    210                 215                 220                 


Gly Cys Ser Cys Pro Gly Glu Ala Gly Ala Gly Ser Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Ser Pro Gly Pro Pro Ala Ala His Xaa Leu Ser Asn Ala Leu Val Pro 
                245                 250                 255     


Gly Gly Pro Ala Pro Pro Ala Glu Ala Asp Leu His Ser Gly Ser Ser 
            260                 265                 270         


Asn Asp Leu Phe Xaa Xaa Glu Met Arg Tyr Gly Glu Glu Pro Glu Glu 
        275                 280                 285             


Glu Pro Lys Val Lys Xaa Gln Trp Pro Arg Ser Ala Asp Glu Pro Gly 
    290                 295                 300                 


Leu Tyr Met Ala Gln Xaa Val His Gly Val Trp Glu Glu Trp Gly Ser 
305                 310                 315                 320 


Trp Ser Leu Cys Ser Arg Ser Cys Gly Arg Gly Ser Arg Ser Arg Met 
                325                 330                 335     


Arg Xaa Cys Val Pro Pro Gln His Gly Gly Lys Ala Cys Glu Gly Pro 
            340                 345                 350         


Glu Leu Gln Xaa Lys Leu Cys Ser Met Ala Ala Cys Pro Val Glu Gly 
        355                 360                 365             


Gln Trp Leu Glu Trp Gly Pro Trp Gly Pro Cys Ser Xaa Ser Cys Ala 
    370                 375                 380                 


Asn Gly Xaa Gln Gln Arg Ser Arg Lys Cys Ser Val Ala Gly Pro Ala 
385                 390                 395                 400 


Trp Ala Xaa Cys Xaa Gly Ala Leu Xaa Asp Xaa Arg Glu Cys Ser Asn 
                405                 410                 415     


Leu Glu Cys Pro Ala Xaa Asp Ser Lys Trp Gly Pro Trp Asn Ala Trp 
            420                 425                 430         


Ser Leu Cys Ser Lys Xaa Cys Asp Xaa Gly Trp Gln Arg Arg Phe Arg 
        435                 440                 445             


Met Cys Gln Ala Xaa Gly Xaa Gln Gly Tyr Pro Cys Glu Gly Xaa Gly 
    450                 455                 460                 


Glu Glu Val Lys Pro Cys Ser Glu Lys Arg Cys Pro Ala Phe His Glu 
465                 470                 475                 480 


Met Cys Arg Asp Glu Tyr Val Met Leu Met Xaa Trp Lys Lys Ala Ala 
                485                 490                 495     


Ala Gly Glu Ile Ile Tyr Asn Lys Cys Pro Pro Asn Ala Ser Gly Ser 
            500                 505                 510         


Ala Ser Arg Arg Cys Leu Leu Ser Ala Gln Gly Val Ala Tyr Trp Gly 
        515                 520                 525             


Leu Pro Ser Phe Ala Arg Cys Ile Ser His Glu Tyr Arg Tyr Leu Tyr 
    530                 535                 540                 


Leu Ser Leu Arg Glu His Leu Ala Lys Gly Gln Arg Met Leu Ala Gly 
545                 550                 555                 560 


Glu Gly Met Ser Gln Val Val Arg Ser Leu Gln Glu Leu Leu Ala Arg 
                565                 570                 575     


Arg Xaa Tyr Tyr Ser Gly Asp Leu Leu Phe Ser Val Asp Ile Leu Arg 
            580                 585                 590         


Asn Val Xaa Asp Xaa Phe Lys Arg Ala Xaa Tyr Val Pro Ser Ala Asp 
        595                 600                 605             


Asp Val Gln Arg Phe Phe Gln Val Val Ser Phe Met Val Asp Ala Glu 
    610                 615                 620                 


Asn Lys Glu Lys Trp Asp Asp Ala Gln Gln Val Ser Pro Gly Ser Val 
625                 630                 635                 640 


His Leu Leu Arg Val Val Glu Asp Phe Ile His Leu Val Gly Asp Ala 
                645                 650                 655     


Leu Lys Ala Phe Gln Ser Ser Leu Ile Val Xaa Asp Asn Leu Val Ile 
            660                 665                 670         


Ser Ile Gln Arg Glu Pro Val Ser Ala Val Ser Ser Asp Ile Xaa Phe 
        675                 680                 685             


Pro Met Arg Gly Arg Arg Gly Met Lys Asp Trp Val Arg His Ser Glu 
    690                 695                 700                 


Asp Arg Leu Phe Leu Pro Lys Glu Val Leu Ser Leu Ser Ser Pro Gly 
705                 710                 715                 720 


Lys Pro Ala Xaa Ser Gly Ala Ala Gly Ser Pro Gly Arg Gly Arg Gly 
                725                 730                 735     


Pro Gly Xaa Val Pro Pro Gly Pro Gly His Ser His Gln Arg Leu Leu 
            740                 745                 750         


Pro Ala Asp Pro Asp Glu Ser Ser Tyr Phe Val Ile Gly Ala Val Leu 
        755                 760                 765             


Tyr Arg Xaa Leu Gly Leu Ile Leu Pro Pro Pro Arg Pro Pro Leu Ala 
    770                 775                 780                 


Val Xaa Ser Arg Val Met Xaa Val Xaa Val Arg Pro Pro Xaa Gln Pro 
785                 790                 795                 800 


Pro Ala Glu Pro Leu Ile Xaa Val Glu Leu Ser Tyr Ile Ile Asn Gly 
                805                 810                 815     


Xaa Xaa Asp Pro His Cys Ala Ser Trp Asp Tyr Ser Arg Ala Asp Ala 
            820                 825                 830         


Ser Ser Gly Asp Trp Asp Xaa Glu Asn Cys Gln Xaa Leu Glu Xaa Gln 
        835                 840                 845             


Ala Ala His Xaa Arg Cys Gln Cys Gln His Leu Ser Xaa Phe Ala Val 
    850                 855                 860                 


Leu Ala Gln Pro Pro Lys Asp Leu Xaa Leu Glu Leu Ala Gly Ser Pro 
865                 870                 875                 880 


Ser Val Pro Leu Val Ile Gly Cys Ala Val Ser Cys Met Ala Leu Leu 
                885                 890                 895     


Xaa Leu Leu Ala Ile Tyr Ala Ala Phe Trp Arg Phe Ile Lys Ser Glu 
            900                 905                 910         


Arg Ser Ile Ile Leu Leu Asn Phe Cys Leu Ser Ile Leu Ala Ser Asn 
        915                 920                 925             


Ile Leu Ile Leu Val Gly Gln Ser Arg Val Leu Ser Lys Gly Val Cys 
    930                 935                 940                 


Xaa Met Xaa Ala Ala Phe Leu His Phe Phe Phe Leu Ser Ser Phe Cys 
945                 950                 955                 960 


Trp Val Leu Xaa Glu Ala Trp Gln Ser Tyr Leu Ala Val Ile Gly Arg 
                965                 970                 975     


Met Arg Xaa Arg Leu Val Arg Lys Arg Phe Leu Cys Leu Gly Trp Gly 
            980                 985                 990         


Leu Pro Ala Leu Val Val Ala Val  Ser Val Gly Phe Xaa  Arg Xaa Lys 
        995                 1000                 1005             


Gly Tyr  Gly Xaa Ser Ser Tyr  Cys Trp Leu Ser Leu  Glu Gly Gly 
    1010                 1015                 1020             


Leu Leu  Tyr Ala Phe Val Gly  Pro Ala Ala Val Ile  Val Leu Val 
    1025                 1030                 1035             


Asn Met  Leu Ile Gly Ile Ile  Val Phe Asn Lys Leu  Met Ala Arg 
    1040                 1045                 1050             


Asp Gly  Ile Ser Asp Lys Ser  Lys Lys Gln Arg Ala  Gly Ala Ser 
    1055                 1060                 1065             


Leu Trp  Ser Ser Cys Val Val  Leu Pro Leu Leu Ala  Leu Xaa Trp 
    1070                 1075                 1080             


Met Ser  Ala Val Leu Ala Met  Xaa Asp Arg Arg Ser  Val Leu Phe 
    1085                 1090                 1095             


Gln Ala  Leu Phe Ala Val Phe  Asn Ser Ala Gln Gly  Phe Val Ile 
    1100                 1105                 1110             


Xaa Ala  Val His Cys Phe Leu  Arg Arg Glu Val Gln  Asp Val Val 
    1115                 1120                 1125             


Lys Cys  Gln Met Gly Val Cys  Arg Ala Asp Glu Ser  Glu Asp Ser 
    1130                 1135                 1140             


Pro Asp  Ser Cys Lys Asn Gly  Gln Leu Gln Ile Leu  Ser Asp Phe 
    1145                 1150                 1155             


Glu Lys  Asp Val Asp Leu Ala  Cys Gln Xaa Val Leu  Phe Lys Glu 
    1160                 1165                 1170             


Val Asn  Xaa Cys Asn Pro Ser  Xaa Ile Xaa Gly Xaa  Leu Ser Arg 
    1175                 1180                 1185             


Leu Ser  Leu Asp Glu Asp Glu  Glu Pro Lys Ser Cys  Leu Val Gly 
    1190                 1195                 1200             


Pro Glu  Gly Ser Leu Ser Phe  Ser Pro Leu Pro Gly  Asn Ile Leu 
    1205                 1210                 1215             


Val Pro  Met Ala Ala Ser Pro  Gly Leu Gly Glu Pro  Pro Pro Pro 
    1220                 1225                 1230             


Gln Glu  Ala Asn Pro Val Tyr  Met Cys Gly Glu Gly  Gly Leu Arg 
    1235                 1240                 1245             


Gln Leu  Asp Leu Xaa Trp Leu  Arg Pro Xaa Glu Pro  Gly Ser Glu 
    1250                 1255                 1260             


Gly Asp  Tyr Met Val Leu Pro  Arg Arg Xaa Leu Ser  Leu Gln Pro 
    1265                 1270                 1275             


Gly Gly  Gly Gly Gly Gly Gly  Glu Asp Ala Pro Arg  Ala Arg Pro 
    1280                 1285                 1290             


Glu Gly  Xaa Pro Arg Arg Ala  Ala Lys Xaa Val Ala  His Xaa Glu 
    1295                 1300                 1305             


Gly Tyr  Pro Ser Phe Leu Ser  Val Asp His Ser Gly  Leu Gly Leu 
    1310                 1315                 1320             


Gly Pro  Ala Tyr Gly Ser Leu  Gln Asn Pro Tyr Gly  Met Xaa Phe 
    1325                 1330                 1335             


Gln Pro  Pro Pro Pro Xaa Pro  Ser Ala Arg Gln Val  Pro Glu Pro 
    1340                 1345                 1350             


Gly Glu  Arg Ser Arg Xaa Met  Pro Arg Xaa Val Pro  Gly Ser Xaa 
    1355                 1360                 1365             


Met Lys  Met Gly Ser Leu Glu  Arg Lys Lys Leu Arg  Tyr Ser Asp 
    1370                 1375                 1380             


Leu Asp  Phe Glu Lys Val Met  His Xaa Arg Lys Arg  His Ser Glu 
    1385                 1390                 1395             


Leu Tyr  His Glu Leu Asn Gln  Lys Phe His Xaa Phe  Asp Arg Tyr 
    1400                 1405                 1410             


Arg Ser  Gln Ser Xaa Ala Lys  Arg Glu Lys Arg Trp  Ser Val Ser 
    1415                 1420                 1425             


Ser Gly  Gly Ala Ala Glu Arg  Ser Val Cys Xaa Asp  Lys Pro Ser 
    1430                 1435                 1440             


Pro Gly  Glu Arg Pro Ser Leu  Ser Gln His Arg Arg  His Gln Ser 
    1445                 1450                 1455             


Trp Ser  Xaa Phe Lys Ser Met  Xaa Leu Gly Ser Leu  Pro Pro Lys 
    1460                 1465                 1470             


Pro Arg  Glu Arg Leu Xaa Leu  His Arg Ala Ala Ala  Trp Glu Pro 
    1475                 1480                 1485             


Xaa Glu  Pro Pro Asp Gly Asp  Phe Gln Xaa Glu Val  
    1490                 1495                 1500 


<210> 1622
<211> 1466
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1161)..(1161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1238)..(1238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1243)..(1243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1281)..(1281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1322)..(1322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1344)..(1344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1353)..(1353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1377)..(1377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1394)..(1394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1403)..(1403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1432)..(1432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1464)..(1464)
<223> Selenocysteine

<400> 1622
Met Xaa Pro Ala Cys Pro Leu Leu Leu Ser Val Ile Leu Ser Leu Arg 
1               5                   10                  15      


Leu Ala Xaa Ala Phe Asp Pro Ala Pro Ser Ala Cys Ser Ala Leu Ala 
            20                  25                  30          


Ser Gly Val Leu Tyr Gly Ala Phe Ser Leu Gln Asp Leu Phe Pro Xaa 
        35                  40                  45              


Ile Ala Ser Gly Cys Ser Trp Xaa Leu Glu Asn Pro Asp Pro Xaa Lys 
    50                  55                  60                  


Tyr Ser Leu Tyr Leu Arg Phe Asn Arg Gln Glu Gln Val Cys Ala His 
65                  70                  75                  80  


Phe Ala Pro Arg Leu Leu Pro Leu Asp His Tyr Leu Val Asn Phe Xaa 
                85                  90                  95      


Cys Leu Arg Pro Ser Pro Glu Glu Ala Val Ala Gln Ala Glu Ser Glu 
            100                 105                 110         


Val Gly Arg Pro Glu Glu Glu Glu Ala Glu Ala Ala Ala Gly Leu Glu 
        115                 120                 125             


Leu Cys Ser Gly Ser Gly Pro Phe Xaa Phe Leu His Phe Asp Lys Asn 
    130                 135                 140                 


Phe Val Gln Leu Cys Leu Ser Ala Glu Pro Ser Glu Ala Pro Arg Leu 
145                 150                 155                 160 


Leu Ala Pro Ala Ala Leu Ala Phe Arg Phe Val Glu Val Leu Leu Ile 
                165                 170                 175     


Asn Asn Asn Asn Ser Ser Gln Phe Xaa Cys Gly Val Leu Cys Arg Trp 
            180                 185                 190         


Ser Glu Glu Cys Gly Arg Ala Ala Gly Arg Ala Cys Gly Phe Ala Gln 
        195                 200                 205             


Pro Gly Cys Ser Cys Pro Gly Glu Ala Gly Ala Gly Ser Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Ser Pro Gly Pro Pro Ala Ala His Xaa Leu Ser Asn Ala Leu Val 
225                 230                 235                 240 


Pro Gly Gly Pro Ala Pro Pro Ala Glu Ala Asp Leu His Ser Gly Ser 
                245                 250                 255     


Ser Asn Asp Leu Phe Xaa Xaa Glu Met Arg Tyr Gly Glu Glu Pro Glu 
            260                 265                 270         


Glu Glu Pro Lys Val Lys Xaa Gln Trp Pro Arg Ser Ala Asp Glu Pro 
        275                 280                 285             


Gly Leu Tyr Met Ala Gln Xaa Gly Asp Pro Ala Ala Glu Glu Trp Ser 
    290                 295                 300                 


Pro Trp Ser Val Cys Ser Leu Xaa Cys Gly Gln Gly Leu Gln Val Arg 
305                 310                 315                 320 


Xaa Arg Ser Cys Val Ser Ser Pro Tyr Gly Xaa Leu Cys Ser Gly Pro 
                325                 330                 335     


Leu Arg Glu Xaa Arg Pro Cys Asn Asn Ser Ala Xaa Cys Pro Val Glu 
            340                 345                 350         


Gly Gln Trp Leu Glu Trp Gly Pro Trp Gly Pro Cys Ser Xaa Ser Cys 
        355                 360                 365             


Ala Asn Gly Xaa Gln Gln Arg Ser Arg Lys Cys Ser Val Ala Gly Pro 
    370                 375                 380                 


Ala Trp Ala Xaa Cys Xaa Gly Ala Leu Xaa Asp Xaa Arg Glu Cys Ser 
385                 390                 395                 400 


Asn Leu Glu Cys Pro Ala Xaa Asp Ser Lys Trp Gly Pro Trp Asn Ala 
                405                 410                 415     


Trp Ser Leu Cys Ser Lys Xaa Cys Asp Xaa Gly Trp Gln Arg Arg Phe 
            420                 425                 430         


Arg Met Cys Gln Ala Xaa Gly Xaa Gln Gly Tyr Pro Cys Glu Gly Xaa 
        435                 440                 445             


Gly Glu Glu Val Lys Pro Cys Ser Glu Lys Arg Cys Pro Ala Phe His 
    450                 455                 460                 


Glu Met Cys Arg Asp Glu Tyr Val Met Leu Met Xaa Trp Lys Lys Ala 
465                 470                 475                 480 


Ala Ala Gly Glu Ile Ile Tyr Asn Lys Cys Pro Pro Asn Ala Ser Gly 
                485                 490                 495     


Ser Ala Ser Arg Arg Cys Leu Leu Ser Ala Gln Gly Val Ala Tyr Trp 
            500                 505                 510         


Gly Leu Pro Ser Phe Ala Arg Cys Ile Ser His Glu Tyr Arg Tyr Leu 
        515                 520                 525             


Tyr Leu Ser Leu Arg Glu His Leu Ala Lys Gly Gln Arg Met Leu Ala 
    530                 535                 540                 


Gly Glu Gly Met Ser Gln Val Val Arg Ser Leu Gln Glu Leu Leu Ala 
545                 550                 555                 560 


Arg Arg Xaa Tyr Tyr Ser Gly Asp Leu Leu Phe Ser Val Asp Ile Leu 
                565                 570                 575     


Arg Asn Val Xaa Asp Xaa Phe Lys Arg Ala Xaa Tyr Val Pro Ser Ala 
            580                 585                 590         


Asp Asp Val Gln Arg Phe Phe Gln Val Val Ser Phe Met Val Asp Ala 
        595                 600                 605             


Glu Asn Lys Glu Lys Trp Asp Asp Ala Gln Gln Val Ser Pro Gly Ser 
    610                 615                 620                 


Val His Leu Leu Arg Val Val Glu Asp Phe Ile His Leu Val Gly Asp 
625                 630                 635                 640 


Ala Leu Lys Ala Phe Gln Ser Ser Leu Ile Val Xaa Asp Asn Leu Val 
                645                 650                 655     


Ile Ser Ile Gln Arg Glu Pro Val Ser Ala Val Ser Ser Asp Ile Xaa 
            660                 665                 670         


Phe Pro Met Arg Gly Arg Arg Gly Met Lys Asp Trp Val Arg His Ser 
        675                 680                 685             


Glu Asp Arg Leu Phe Leu Pro Lys Glu Val Leu Ser Leu Ser Ser Pro 
    690                 695                 700                 


Gly Lys Pro Ala Xaa Ser Gly Ala Ala Gly Ser Pro Gly Arg Gly Arg 
705                 710                 715                 720 


Gly Pro Gly Xaa Val Pro Pro Gly Pro Gly His Ser His Gln Arg Leu 
                725                 730                 735     


Leu Pro Ala Asp Pro Asp Glu Ser Ser Tyr Phe Val Ile Gly Ala Val 
            740                 745                 750         


Leu Tyr Arg Xaa Leu Gly Leu Ile Leu Pro Pro Pro Arg Pro Pro Leu 
        755                 760                 765             


Ala Val Xaa Ser Arg Val Met Xaa Val Xaa Val Arg Pro Pro Xaa Gln 
    770                 775                 780                 


Pro Pro Ala Glu Pro Leu Ile Xaa Val Glu Leu Ser Tyr Ile Ile Asn 
785                 790                 795                 800 


Gly Xaa Xaa Asp Pro His Cys Ala Ser Trp Asp Tyr Ser Arg Ala Asp 
                805                 810                 815     


Ala Ser Ser Gly Asp Trp Asp Xaa Glu Asn Cys Gln Xaa Leu Glu Xaa 
            820                 825                 830         


Gln Ala Ala His Xaa Arg Cys Gln Cys Gln His Leu Ser Xaa Phe Ala 
        835                 840                 845             


Val Leu Ala Gln Pro Pro Lys Asp Leu Xaa Leu Glu Leu Ala Gly Ser 
    850                 855                 860                 


Pro Ser Val Pro Leu Val Ile Gly Cys Ala Val Ser Cys Met Ala Leu 
865                 870                 875                 880 


Leu Xaa Leu Leu Ala Ile Tyr Ala Ala Phe Trp Arg Phe Ile Lys Ser 
                885                 890                 895     


Glu Arg Ser Ile Ile Leu Leu Asn Phe Cys Leu Ser Ile Leu Ala Ser 
            900                 905                 910         


Asn Ile Leu Ile Leu Val Gly Gln Ser Arg Val Leu Ser Lys Gly Val 
        915                 920                 925             


Cys Xaa Met Xaa Ala Ala Phe Leu His Phe Phe Phe Leu Ser Ser Phe 
    930                 935                 940                 


Cys Trp Val Leu Xaa Glu Ala Trp Gln Ser Tyr Leu Ala Val Ile Gly 
945                 950                 955                 960 


Arg Met Arg Xaa Arg Leu Val Arg Lys Arg Phe Leu Cys Leu Gly Trp 
                965                 970                 975     


Gly Leu Pro Ala Leu Val Val Ala Val Ser Val Gly Phe Xaa Arg Xaa 
            980                 985                 990         


Lys Gly Tyr Gly Xaa Ser Ser Tyr  Cys Trp Leu Ser Leu  Glu Gly Gly 
        995                 1000                 1005             


Leu Leu  Tyr Ala Phe Val Gly  Pro Ala Ala Val Ile  Val Leu Val 
    1010                 1015                 1020             


Asn Met  Leu Ile Gly Ile Ile  Val Phe Asn Lys Leu  Met Ala Arg 
    1025                 1030                 1035             


Asp Gly  Ile Ser Asp Lys Ser  Lys Lys Gln Arg Ala  Gly Ala Ser 
    1040                 1045                 1050             


Leu Trp  Ser Ser Cys Val Val  Leu Pro Leu Leu Ala  Leu Xaa Trp 
    1055                 1060                 1065             


Met Ser  Ala Val Leu Ala Met  Xaa Asp Arg Arg Ser  Val Leu Phe 
    1070                 1075                 1080             


Gln Ala  Leu Phe Ala Val Phe  Asn Ser Ala Gln Gly  Phe Val Ile 
    1085                 1090                 1095             


Xaa Ala  Val His Cys Phe Leu  Arg Arg Glu Val Gln  Asp Val Val 
    1100                 1105                 1110             


Lys Cys  Gln Met Gly Val Cys  Arg Ala Asp Glu Ser  Glu Asp Ser 
    1115                 1120                 1125             


Pro Asp  Ser Cys Lys Asn Gly  Gln Leu Gln Ile Leu  Ser Asp Phe 
    1130                 1135                 1140             


Glu Lys  Asp Val Asp Leu Ala  Cys Gln Xaa Val Leu  Phe Lys Glu 
    1145                 1150                 1155             


Val Asn  Xaa Cys Asn Pro Ser  Xaa Ile Xaa Gly Xaa  Leu Ser Arg 
    1160                 1165                 1170             


Leu Ser  Leu Asp Glu Asp Glu  Glu Pro Lys Ser Cys  Leu Val Gly 
    1175                 1180                 1185             


Pro Glu  Gly Ser Leu Ser Phe  Ser Pro Leu Pro Gly  Asn Ile Leu 
    1190                 1195                 1200             


Val Pro  Met Ala Ala Ser Pro  Gly Leu Gly Glu Pro  Pro Pro Pro 
    1205                 1210                 1215             


Gln Glu  Ala Asn Pro Val Tyr  Met Cys Gly Glu Gly  Gly Leu Arg 
    1220                 1225                 1230             


Gln Leu  Asp Leu Xaa Trp Leu  Arg Pro Xaa Glu Pro  Gly Ser Glu 
    1235                 1240                 1245             


Gly Asp  Tyr Met Val Leu Pro  Arg Arg Xaa Leu Ser  Leu Gln Pro 
    1250                 1255                 1260             


Gly Gly  Gly Gly Gly Gly Gly  Glu Asp Ala Pro Arg  Ala Arg Pro 
    1265                 1270                 1275             


Glu Gly  Xaa Pro Arg Arg Ala  Ala Lys Xaa Val Ala  His Xaa Glu 
    1280                 1285                 1290             


Gly Tyr  Pro Ser Phe Leu Ser  Val Asp His Ser Gly  Leu Gly Leu 
    1295                 1300                 1305             


Gly Pro  Ala Tyr Gly Ser Leu  Gln Asn Pro Tyr Gly  Met Xaa Phe 
    1310                 1315                 1320             


Gln Pro  Pro Pro Pro Xaa Pro  Ser Ala Arg Gln Val  Pro Glu Pro 
    1325                 1330                 1335             


Gly Glu  Arg Ser Arg Xaa Met  Pro Arg Xaa Val Pro  Gly Ser Xaa 
    1340                 1345                 1350             


Met Lys  Met Gly Ser Leu Glu  Arg Lys Lys Leu Arg  Tyr Ser Asp 
    1355                 1360                 1365             


Leu Asp  Phe Glu Lys Val Met  His Xaa Arg Lys Arg  His Ser Glu 
    1370                 1375                 1380             


Leu Tyr  His Glu Leu Asn Gln  Lys Phe His Xaa Phe  Asp Arg Tyr 
    1385                 1390                 1395             


Arg Ser  Gln Ser Xaa Ala Lys  Asp Lys Pro Ser Pro  Gly Glu Arg 
    1400                 1405                 1410             


Pro Ser  Leu Ser Gln His Arg  Arg His Gln Ser Trp  Ser Xaa Phe 
    1415                 1420                 1425             


Lys Ser  Met Xaa Leu Gly Ser  Leu Pro Pro Lys Pro  Arg Glu Arg 
    1430                 1435                 1440             


Leu Xaa  Leu His Arg Ala Ala  Ala Trp Glu Pro Xaa  Glu Pro Pro 
    1445                 1450                 1455             


Asp Gly  Asp Phe Gln Xaa Glu  Val 
    1460                 1465     


<210> 1623
<211> 1499
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1276)..(1276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1291)..(1291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1314)..(1314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1321)..(1321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1325)..(1325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1355)..(1355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1377)..(1377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1386)..(1386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1410)..(1410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1436)..(1436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1460)..(1460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1465)..(1465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1478)..(1478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1488)..(1488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1497)..(1497)
<223> Selenocysteine

<400> 1623
Met Xaa Pro Ala Cys Pro Leu Leu Leu Ser Val Ile Leu Ser Leu Arg 
1               5                   10                  15      


Leu Ala Xaa Ala Phe Asp Pro Ala Pro Ser Ala Cys Ser Ala Leu Ala 
            20                  25                  30          


Ser Gly Val Leu Tyr Gly Ala Phe Ser Leu Gln Asp Leu Phe Pro Xaa 
        35                  40                  45              


Ile Ala Ser Gly Cys Ser Trp Xaa Leu Glu Asn Pro Asp Pro Xaa Lys 
    50                  55                  60                  


Tyr Ser Leu Tyr Leu Arg Phe Asn Arg Gln Glu Gln Val Cys Ala His 
65                  70                  75                  80  


Phe Ala Pro Arg Leu Leu Pro Leu Asp His Tyr Leu Val Asn Phe Xaa 
                85                  90                  95      


Cys Leu Arg Pro Ser Pro Glu Glu Ala Val Ala Gln Ala Glu Ser Glu 
            100                 105                 110         


Val Gly Arg Pro Glu Glu Glu Glu Ala Glu Ala Ala Ala Gly Leu Glu 
        115                 120                 125             


Leu Cys Ser Gly Ser Gly Pro Phe Xaa Phe Leu His Phe Asp Lys Asn 
    130                 135                 140                 


Phe Val Gln Leu Cys Leu Ser Ala Glu Pro Ser Glu Ala Pro Arg Leu 
145                 150                 155                 160 


Leu Ala Pro Ala Ala Leu Ala Phe Arg Phe Val Glu Val Leu Leu Ile 
                165                 170                 175     


Asn Asn Asn Asn Ser Ser Gln Phe Xaa Cys Gly Val Leu Cys Arg Trp 
            180                 185                 190         


Ser Glu Glu Cys Gly Arg Ala Ala Gly Arg Ala Cys Gly Phe Ala Gln 
        195                 200                 205             


Pro Gly Cys Ser Cys Pro Gly Glu Ala Gly Ala Gly Ser Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Ser Pro Gly Pro Pro Ala Ala His Xaa Leu Ser Asn Ala Leu Val 
225                 230                 235                 240 


Pro Gly Gly Pro Ala Pro Pro Ala Glu Ala Asp Leu His Ser Gly Ser 
                245                 250                 255     


Ser Asn Asp Leu Phe Xaa Xaa Glu Met Arg Tyr Gly Glu Glu Pro Glu 
            260                 265                 270         


Glu Glu Pro Lys Val Lys Xaa Gln Trp Pro Arg Ser Ala Asp Glu Pro 
        275                 280                 285             


Gly Leu Tyr Met Ala Gln Xaa Val His Gly Val Trp Glu Glu Trp Gly 
    290                 295                 300                 


Ser Trp Ser Leu Cys Ser Arg Ser Cys Gly Arg Gly Ser Arg Ser Arg 
305                 310                 315                 320 


Met Arg Xaa Cys Val Pro Pro Gln His Gly Gly Lys Ala Cys Glu Gly 
                325                 330                 335     


Pro Glu Leu Gln Xaa Lys Leu Cys Ser Met Ala Ala Cys Pro Val Glu 
            340                 345                 350         


Gly Gln Trp Leu Glu Trp Gly Pro Trp Gly Pro Cys Ser Xaa Ser Cys 
        355                 360                 365             


Ala Asn Gly Xaa Gln Gln Arg Ser Arg Lys Cys Ser Val Ala Gly Pro 
    370                 375                 380                 


Ala Trp Ala Xaa Cys Xaa Gly Ala Leu Xaa Asp Xaa Arg Glu Cys Ser 
385                 390                 395                 400 


Asn Leu Glu Cys Pro Ala Xaa Asp Ser Lys Trp Gly Pro Trp Asn Ala 
                405                 410                 415     


Trp Ser Leu Cys Ser Lys Xaa Cys Asp Xaa Gly Trp Gln Arg Arg Phe 
            420                 425                 430         


Arg Met Cys Gln Ala Xaa Gly Xaa Gln Gly Tyr Pro Cys Glu Gly Xaa 
        435                 440                 445             


Gly Glu Glu Val Lys Pro Cys Ser Glu Lys Arg Cys Pro Ala Phe His 
    450                 455                 460                 


Glu Met Cys Arg Asp Glu Tyr Val Met Leu Met Xaa Trp Lys Lys Ala 
465                 470                 475                 480 


Ala Ala Gly Glu Ile Ile Tyr Asn Lys Cys Pro Pro Asn Ala Ser Gly 
                485                 490                 495     


Ser Ala Ser Arg Arg Cys Leu Leu Ser Ala Gln Gly Val Ala Tyr Trp 
            500                 505                 510         


Gly Leu Pro Ser Phe Ala Arg Cys Ile Ser His Glu Tyr Arg Tyr Leu 
        515                 520                 525             


Tyr Leu Ser Leu Arg Glu His Leu Ala Lys Gly Gln Arg Met Leu Ala 
    530                 535                 540                 


Gly Glu Gly Met Ser Gln Val Val Arg Ser Leu Gln Glu Leu Leu Ala 
545                 550                 555                 560 


Arg Arg Xaa Tyr Tyr Ser Gly Asp Leu Leu Phe Ser Val Asp Ile Leu 
                565                 570                 575     


Arg Asn Val Xaa Asp Xaa Phe Lys Arg Ala Xaa Tyr Val Pro Ser Ala 
            580                 585                 590         


Asp Asp Val Gln Arg Phe Phe Gln Val Val Ser Phe Met Val Asp Ala 
        595                 600                 605             


Glu Asn Lys Glu Lys Trp Asp Asp Ala Gln Gln Val Ser Pro Gly Ser 
    610                 615                 620                 


Val His Leu Leu Arg Val Val Glu Asp Phe Ile His Leu Val Gly Asp 
625                 630                 635                 640 


Ala Leu Lys Ala Phe Gln Ser Ser Leu Ile Val Xaa Asp Asn Leu Val 
                645                 650                 655     


Ile Ser Ile Gln Arg Glu Pro Val Ser Ala Val Ser Ser Asp Ile Xaa 
            660                 665                 670         


Phe Pro Met Arg Gly Arg Arg Gly Met Lys Asp Trp Val Arg His Ser 
        675                 680                 685             


Glu Asp Arg Leu Phe Leu Pro Lys Glu Val Leu Ser Leu Ser Ser Pro 
    690                 695                 700                 


Gly Lys Pro Ala Xaa Ser Gly Ala Ala Gly Ser Pro Gly Arg Gly Arg 
705                 710                 715                 720 


Gly Pro Gly Xaa Val Pro Pro Gly Pro Gly His Ser His Gln Arg Leu 
                725                 730                 735     


Leu Pro Ala Asp Pro Asp Glu Ser Ser Tyr Phe Val Ile Gly Ala Val 
            740                 745                 750         


Leu Tyr Arg Xaa Leu Gly Leu Ile Leu Pro Pro Pro Arg Pro Pro Leu 
        755                 760                 765             


Ala Val Xaa Ser Arg Val Met Xaa Val Xaa Val Arg Pro Pro Xaa Gln 
    770                 775                 780                 


Pro Pro Ala Glu Pro Leu Ile Xaa Val Glu Leu Ser Tyr Ile Ile Asn 
785                 790                 795                 800 


Gly Xaa Xaa Asp Pro His Cys Ala Ser Trp Asp Tyr Ser Arg Ala Asp 
                805                 810                 815     


Ala Ser Ser Gly Asp Trp Asp Xaa Glu Asn Cys Gln Xaa Leu Glu Xaa 
            820                 825                 830         


Gln Ala Ala His Xaa Arg Cys Gln Cys Gln His Leu Ser Xaa Phe Ala 
        835                 840                 845             


Val Leu Ala Gln Pro Pro Lys Asp Leu Xaa Leu Glu Leu Ala Gly Ser 
    850                 855                 860                 


Pro Ser Val Pro Leu Val Ile Gly Cys Ala Val Ser Cys Met Ala Leu 
865                 870                 875                 880 


Leu Xaa Leu Leu Ala Ile Tyr Ala Ala Phe Trp Arg Phe Ile Lys Ser 
                885                 890                 895     


Glu Arg Ser Ile Ile Leu Leu Asn Phe Cys Leu Ser Ile Leu Ala Ser 
            900                 905                 910         


Asn Ile Leu Ile Leu Val Gly Gln Ser Arg Val Leu Ser Lys Gly Val 
        915                 920                 925             


Cys Xaa Met Xaa Ala Ala Phe Leu His Phe Phe Phe Leu Ser Ser Phe 
    930                 935                 940                 


Cys Trp Val Leu Xaa Glu Ala Trp Gln Ser Tyr Leu Ala Val Ile Gly 
945                 950                 955                 960 


Arg Met Arg Xaa Arg Leu Val Arg Lys Arg Phe Leu Cys Leu Gly Trp 
                965                 970                 975     


Gly Leu Pro Ala Leu Val Val Ala Val Ser Val Gly Phe Xaa Arg Xaa 
            980                 985                 990         


Lys Gly Tyr Gly Xaa Ser Ser Tyr  Cys Trp Leu Ser Leu  Glu Gly Gly 
        995                 1000                 1005             


Leu Leu  Tyr Ala Phe Val Gly  Pro Ala Ala Val Ile  Val Leu Val 
    1010                 1015                 1020             


Asn Met  Leu Ile Gly Ile Ile  Val Phe Asn Lys Leu  Met Ala Arg 
    1025                 1030                 1035             


Asp Gly  Ile Ser Asp Lys Ser  Lys Lys Gln Arg Ala  Gly Ser Glu 
    1040                 1045                 1050             


Arg Cys  Pro Trp Ala Ser Leu  Leu Leu Pro Cys Ser  Ala Cys Gly 
    1055                 1060                 1065             


Ala Val  Pro Ser Pro Leu Leu  Ser Ser Ala Ser Ala  Arg Asn Ala 
    1070                 1075                 1080             


Met Ala  Ser Leu Trp Ser Ser  Cys Val Val Leu Pro  Leu Leu Ala 
    1085                 1090                 1095             


Leu Xaa  Trp Met Ser Ala Val  Leu Ala Met Xaa Asp  Arg Arg Ser 
    1100                 1105                 1110             


Val Leu  Phe Gln Ala Leu Phe  Ala Val Phe Asn Ser  Ala Gln Gly 
    1115                 1120                 1125             


Phe Val  Ile Xaa Ala Val His  Cys Phe Leu Arg Arg  Glu Val Gln 
    1130                 1135                 1140             


Asp Val  Val Lys Cys Gln Met  Gly Val Cys Arg Ala  Asp Glu Ser 
    1145                 1150                 1155             


Glu Asp  Ser Pro Asp Ser Cys  Lys Asn Gly Gln Leu  Gln Ile Leu 
    1160                 1165                 1170             


Ser Asp  Phe Glu Lys Asp Val  Asp Leu Ala Cys Gln  Xaa Val Leu 
    1175                 1180                 1185             


Phe Lys  Glu Val Asn Xaa Cys  Asn Pro Ser Xaa Ile  Xaa Gly Xaa 
    1190                 1195                 1200             


Leu Ser  Arg Leu Ser Leu Asp  Glu Asp Glu Glu Pro  Lys Ser Cys 
    1205                 1210                 1215             


Leu Val  Gly Pro Glu Gly Ser  Leu Ser Phe Ser Pro  Leu Pro Gly 
    1220                 1225                 1230             


Asn Ile  Leu Val Pro Met Ala  Ala Ser Pro Gly Leu  Gly Glu Pro 
    1235                 1240                 1245             


Pro Pro  Pro Gln Glu Ala Asn  Pro Val Tyr Met Cys  Gly Glu Gly 
    1250                 1255                 1260             


Gly Leu  Arg Gln Leu Asp Leu  Xaa Trp Leu Arg Pro  Xaa Glu Pro 
    1265                 1270                 1275             


Gly Ser  Glu Gly Asp Tyr Met  Val Leu Pro Arg Arg  Xaa Leu Ser 
    1280                 1285                 1290             


Leu Gln  Pro Gly Gly Gly Gly  Gly Gly Gly Glu Asp  Ala Pro Arg 
    1295                 1300                 1305             


Ala Arg  Pro Glu Gly Xaa Pro  Arg Arg Ala Ala Lys  Xaa Val Ala 
    1310                 1315                 1320             


His Xaa  Glu Gly Tyr Pro Ser  Phe Leu Ser Val Asp  His Ser Gly 
    1325                 1330                 1335             


Leu Gly  Leu Gly Pro Ala Tyr  Gly Ser Leu Gln Asn  Pro Tyr Gly 
    1340                 1345                 1350             


Met Xaa  Phe Gln Pro Pro Pro  Pro Xaa Pro Ser Ala  Arg Gln Val 
    1355                 1360                 1365             


Pro Glu  Pro Gly Glu Arg Ser  Arg Xaa Met Pro Arg  Xaa Val Pro 
    1370                 1375                 1380             


Gly Ser  Xaa Met Lys Met Gly  Ser Leu Glu Arg Lys  Lys Leu Arg 
    1385                 1390                 1395             


Tyr Ser  Asp Leu Asp Phe Glu  Lys Val Met His Xaa  Arg Lys Arg 
    1400                 1405                 1410             


His Ser  Glu Leu Tyr His Glu  Leu Asn Gln Lys Phe  His Xaa Phe 
    1415                 1420                 1425             


Asp Arg  Tyr Arg Ser Gln Ser  Xaa Ala Lys Asp Lys  Pro Ser Pro 
    1430                 1435                 1440             


Gly Glu  Arg Pro Ser Leu Ser  Gln His Arg Arg His  Gln Ser Trp 
    1445                 1450                 1455             


Ser Xaa  Phe Lys Ser Met Xaa  Leu Gly Ser Leu Pro  Pro Lys Pro 
    1460                 1465                 1470             


Arg Glu  Arg Leu Xaa Leu His  Arg Ala Ala Ala Trp  Glu Pro Xaa 
    1475                 1480                 1485             


Glu Pro  Pro Asp Gly Asp Phe  Gln Xaa Glu Val 
    1490                 1495                 


<210> 1624
<211> 1554
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1187)..(1187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1346)..(1346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1369)..(1369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1380)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1410)..(1410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1417)..(1417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1432)..(1432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1436)..(1436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1465)..(1465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1482)..(1482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1491)..(1491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1515)..(1515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1520)..(1520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1533)..(1533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1543)..(1543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1552)..(1552)
<223> Selenocysteine

<400> 1624
Met Xaa Pro Ala Cys Pro Leu Leu Leu Ser Val Ile Leu Ser Leu Arg 
1               5                   10                  15      


Leu Ala Xaa Ala Phe Asp Pro Ala Pro Ser Ala Cys Ser Ala Leu Ala 
            20                  25                  30          


Ser Gly Val Leu Tyr Gly Ala Phe Ser Leu Gln Asp Leu Phe Pro Xaa 
        35                  40                  45              


Ile Ala Ser Gly Cys Ser Trp Xaa Leu Glu Asn Pro Asp Pro Xaa Lys 
    50                  55                  60                  


Tyr Ser Leu Tyr Leu Arg Phe Asn Arg Gln Glu Gln Val Cys Ala His 
65                  70                  75                  80  


Phe Ala Pro Arg Leu Leu Pro Leu Asp His Tyr Leu Val Asn Phe Xaa 
                85                  90                  95      


Cys Leu Arg Pro Ser Pro Glu Glu Ala Val Ala Gln Ala Glu Ser Glu 
            100                 105                 110         


Val Gly Arg Pro Glu Glu Glu Glu Ala Glu Ala Ala Ala Gly Leu Glu 
        115                 120                 125             


Leu Cys Ser Gly Ser Gly Pro Phe Xaa Phe Leu His Phe Asp Lys Asn 
    130                 135                 140                 


Phe Val Gln Leu Cys Leu Ser Ala Glu Pro Ser Glu Ala Pro Arg Leu 
145                 150                 155                 160 


Leu Ala Pro Ala Ala Leu Ala Phe Arg Phe Val Glu Val Leu Leu Ile 
                165                 170                 175     


Asn Asn Asn Asn Ser Ser Gln Phe Xaa Cys Gly Val Leu Cys Arg Trp 
            180                 185                 190         


Ser Glu Glu Cys Gly Arg Ala Ala Gly Arg Ala Cys Gly Phe Ala Gln 
        195                 200                 205             


Pro Gly Cys Ser Cys Pro Gly Glu Ala Gly Ala Gly Ser Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Ser Pro Gly Pro Pro Ala Ala His Xaa Leu Ser Asn Ala Leu Val 
225                 230                 235                 240 


Pro Gly Gly Pro Ala Pro Pro Ala Glu Ala Asp Leu His Ser Gly Ser 
                245                 250                 255     


Ser Asn Asp Leu Phe Xaa Xaa Glu Met Arg Tyr Gly Glu Glu Pro Glu 
            260                 265                 270         


Glu Glu Pro Lys Val Lys Xaa Gln Trp Pro Arg Ser Ala Asp Glu Pro 
        275                 280                 285             


Gly Leu Tyr Met Ala Gln Xaa Gly Asp Pro Ala Ala Glu Glu Trp Ser 
    290                 295                 300                 


Pro Trp Ser Val Cys Ser Leu Xaa Cys Gly Gln Gly Leu Gln Val Arg 
305                 310                 315                 320 


Xaa Arg Ser Cys Val Ser Ser Pro Tyr Gly Xaa Leu Cys Ser Gly Pro 
                325                 330                 335     


Leu Arg Glu Xaa Arg Pro Cys Asn Asn Ser Ala Xaa Cys Pro Val His 
            340                 345                 350         


Gly Val Trp Glu Glu Trp Gly Ser Trp Ser Leu Cys Ser Arg Ser Cys 
        355                 360                 365             


Gly Arg Gly Ser Arg Ser Arg Met Arg Xaa Cys Val Pro Pro Gln His 
    370                 375                 380                 


Gly Gly Lys Ala Cys Glu Gly Pro Glu Leu Gln Xaa Lys Leu Cys Ser 
385                 390                 395                 400 


Met Ala Ala Cys Pro Val Glu Gly Gln Trp Leu Glu Trp Gly Pro Trp 
                405                 410                 415     


Gly Pro Cys Ser Xaa Ser Cys Ala Asn Gly Xaa Gln Gln Arg Ser Arg 
            420                 425                 430         


Lys Cys Ser Val Ala Gly Pro Ala Trp Ala Xaa Cys Xaa Gly Ala Leu 
        435                 440                 445             


Xaa Asp Xaa Arg Glu Cys Ser Asn Leu Glu Cys Pro Ala Xaa Asp Ser 
    450                 455                 460                 


Lys Trp Gly Pro Trp Asn Ala Trp Ser Leu Cys Ser Lys Xaa Cys Asp 
465                 470                 475                 480 


Xaa Gly Trp Gln Arg Arg Phe Arg Met Cys Gln Ala Xaa Gly Xaa Gln 
                485                 490                 495     


Gly Tyr Pro Cys Glu Gly Xaa Gly Glu Glu Val Lys Pro Cys Ser Glu 
            500                 505                 510         


Lys Arg Cys Pro Ala Phe His Glu Met Cys Arg Asp Glu Tyr Val Met 
        515                 520                 525             


Leu Met Xaa Trp Lys Lys Ala Ala Ala Gly Glu Ile Ile Tyr Asn Lys 
    530                 535                 540                 


Cys Pro Pro Asn Ala Ser Gly Ser Ala Ser Arg Arg Cys Leu Leu Ser 
545                 550                 555                 560 


Ala Gln Gly Val Ala Tyr Trp Gly Leu Pro Ser Phe Ala Arg Cys Ile 
                565                 570                 575     


Ser His Glu Tyr Arg Tyr Leu Tyr Leu Ser Leu Arg Glu His Leu Ala 
            580                 585                 590         


Lys Gly Gln Arg Met Leu Ala Gly Glu Gly Met Ser Gln Val Val Arg 
        595                 600                 605             


Ser Leu Gln Glu Leu Leu Ala Arg Arg Xaa Tyr Tyr Ser Gly Asp Leu 
    610                 615                 620                 


Leu Phe Ser Val Asp Ile Leu Arg Asn Val Xaa Asp Xaa Phe Lys Arg 
625                 630                 635                 640 


Ala Xaa Tyr Val Pro Ser Ala Asp Asp Val Gln Arg Phe Phe Gln Val 
                645                 650                 655     


Val Ser Phe Met Val Asp Ala Glu Asn Lys Glu Lys Trp Asp Asp Ala 
            660                 665                 670         


Gln Gln Val Ser Pro Gly Ser Val His Leu Leu Arg Val Val Glu Asp 
        675                 680                 685             


Phe Ile His Leu Val Gly Asp Ala Leu Lys Ala Phe Gln Ser Ser Leu 
    690                 695                 700                 


Ile Val Xaa Asp Asn Leu Val Ile Ser Ile Gln Arg Glu Pro Val Ser 
705                 710                 715                 720 


Ala Val Ser Ser Asp Ile Xaa Phe Pro Met Arg Gly Arg Arg Gly Met 
                725                 730                 735     


Lys Asp Trp Val Arg His Ser Glu Asp Arg Leu Phe Leu Pro Lys Glu 
            740                 745                 750         


Val Leu Ser Leu Ser Ser Pro Gly Lys Pro Ala Xaa Ser Gly Ala Ala 
        755                 760                 765             


Gly Ser Pro Gly Arg Gly Arg Gly Pro Gly Xaa Val Pro Pro Gly Pro 
    770                 775                 780                 


Gly His Ser His Gln Arg Leu Leu Pro Ala Asp Pro Asp Glu Ser Ser 
785                 790                 795                 800 


Tyr Phe Val Ile Gly Ala Val Leu Tyr Arg Xaa Leu Gly Leu Ile Leu 
                805                 810                 815     


Pro Pro Pro Arg Pro Pro Leu Ala Val Xaa Ser Arg Val Met Xaa Val 
            820                 825                 830         


Xaa Val Arg Pro Pro Xaa Gln Pro Pro Ala Glu Pro Leu Ile Xaa Val 
        835                 840                 845             


Glu Leu Ser Tyr Ile Ile Asn Gly Xaa Xaa Asp Pro His Cys Ala Ser 
    850                 855                 860                 


Trp Asp Tyr Ser Arg Ala Asp Ala Ser Ser Gly Asp Trp Asp Xaa Glu 
865                 870                 875                 880 


Asn Cys Gln Xaa Leu Glu Xaa Gln Ala Ala His Xaa Arg Cys Gln Cys 
                885                 890                 895     


Gln His Leu Ser Xaa Phe Ala Val Leu Ala Gln Pro Pro Lys Asp Leu 
            900                 905                 910         


Xaa Leu Glu Leu Ala Gly Ser Pro Ser Val Pro Leu Val Ile Gly Cys 
        915                 920                 925             


Ala Val Ser Cys Met Ala Leu Leu Xaa Leu Leu Ala Ile Tyr Ala Ala 
    930                 935                 940                 


Phe Trp Arg Phe Ile Lys Ser Glu Arg Ser Ile Ile Leu Leu Asn Phe 
945                 950                 955                 960 


Cys Leu Ser Ile Leu Ala Ser Asn Ile Leu Ile Leu Val Gly Gln Ser 
                965                 970                 975     


Arg Val Leu Ser Lys Gly Val Cys Xaa Met Xaa Ala Ala Phe Leu His 
            980                 985                 990         


Phe Phe Phe Leu Ser Ser Phe Cys  Trp Val Leu Xaa Glu  Ala Trp Gln 
        995                 1000                 1005             


Ser Tyr  Leu Ala Val Ile Gly  Arg Met Arg Xaa Arg  Leu Val Arg 
    1010                 1015                 1020             


Lys Arg  Phe Leu Cys Leu Gly  Trp Gly Leu Pro Ala  Leu Val Val 
    1025                 1030                 1035             


Ala Val  Ser Val Gly Phe Xaa  Arg Xaa Lys Gly Tyr  Gly Xaa Ser 
    1040                 1045                 1050             


Ser Tyr  Cys Trp Leu Ser Leu  Glu Gly Gly Leu Leu  Tyr Ala Phe 
    1055                 1060                 1065             


Val Gly  Pro Ala Ala Val Ile  Val Leu Val Asn Met  Leu Ile Gly 
    1070                 1075                 1080             


Ile Ile  Val Phe Asn Lys Leu  Met Ala Arg Asp Gly  Ile Ser Asp 
    1085                 1090                 1095             


Lys Ser  Lys Lys Gln Arg Ala  Gly Ser Glu Arg Cys  Pro Trp Ala 
    1100                 1105                 1110             


Ser Leu  Leu Leu Pro Cys Ser  Ala Cys Gly Ala Val  Pro Ser Pro 
    1115                 1120                 1125             


Leu Leu  Ser Ser Ala Ser Ala  Arg Asn Ala Met Ala  Ser Leu Trp 
    1130                 1135                 1140             


Ser Ser  Cys Val Val Leu Pro  Leu Leu Ala Leu Xaa  Trp Met Ser 
    1145                 1150                 1155             


Ala Val  Leu Ala Met Xaa Asp  Arg Arg Ser Val Leu  Phe Gln Ala 
    1160                 1165                 1170             


Leu Phe  Ala Val Phe Asn Ser  Ala Gln Gly Phe Val  Ile Xaa Ala 
    1175                 1180                 1185             


Val His  Cys Phe Leu Arg Arg  Glu Val Gln Asp Val  Val Lys Cys 
    1190                 1195                 1200             


Gln Met  Gly Val Cys Arg Ala  Asp Glu Ser Glu Asp  Ser Pro Asp 
    1205                 1210                 1215             


Ser Cys  Lys Asn Gly Gln Leu  Gln Ile Leu Ser Asp  Phe Glu Lys 
    1220                 1225                 1230             


Asp Val  Asp Leu Ala Cys Gln  Xaa Val Leu Phe Lys  Glu Val Asn 
    1235                 1240                 1245             


Xaa Cys  Asn Pro Ser Xaa Ile  Xaa Gly Xaa Leu Ser  Arg Leu Ser 
    1250                 1255                 1260             


Leu Asp  Glu Asp Glu Glu Pro  Lys Ser Cys Leu Val  Gly Pro Glu 
    1265                 1270                 1275             


Gly Ser  Leu Ser Phe Ser Pro  Leu Pro Gly Asn Ile  Leu Val Pro 
    1280                 1285                 1290             


Met Ala  Ala Ser Pro Gly Leu  Gly Glu Pro Pro Pro  Pro Gln Glu 
    1295                 1300                 1305             


Ala Asn  Pro Val Tyr Met Cys  Gly Glu Gly Gly Leu  Arg Gln Leu 
    1310                 1315                 1320             


Asp Leu  Xaa Trp Leu Arg Pro  Xaa Glu Pro Gly Ser  Glu Gly Asp 
    1325                 1330                 1335             


Tyr Met  Val Leu Pro Arg Arg  Xaa Leu Ser Leu Gln  Pro Gly Gly 
    1340                 1345                 1350             


Gly Gly  Gly Gly Gly Glu Asp  Ala Pro Arg Ala Arg  Pro Glu Gly 
    1355                 1360                 1365             


Xaa Pro  Arg Arg Ala Ala Lys  Xaa Val Ala His Xaa  Glu Gly Tyr 
    1370                 1375                 1380             


Pro Ser  Phe Leu Ser Val Asp  His Ser Gly Leu Gly  Leu Gly Pro 
    1385                 1390                 1395             


Ala Tyr  Gly Ser Leu Gln Asn  Pro Tyr Gly Met Xaa  Phe Gln Pro 
    1400                 1405                 1410             


Pro Pro  Pro Xaa Pro Ser Ala  Arg Gln Val Pro Glu  Pro Gly Glu 
    1415                 1420                 1425             


Arg Ser  Arg Xaa Met Pro Arg  Xaa Val Pro Gly Ser  Xaa Met Lys 
    1430                 1435                 1440             


Met Gly  Ser Leu Glu Arg Lys  Lys Leu Arg Tyr Ser  Asp Leu Asp 
    1445                 1450                 1455             


Phe Glu  Lys Val Met His Xaa  Arg Lys Arg His Ser  Glu Leu Tyr 
    1460                 1465                 1470             


His Glu  Leu Asn Gln Lys Phe  His Xaa Phe Asp Arg  Tyr Arg Ser 
    1475                 1480                 1485             


Gln Ser  Xaa Ala Lys Asp Lys  Pro Ser Pro Gly Glu  Arg Pro Ser 
    1490                 1495                 1500             


Leu Ser  Gln His Arg Arg His  Gln Ser Trp Ser Xaa  Phe Lys Ser 
    1505                 1510                 1515             


Met Xaa  Leu Gly Ser Leu Pro  Pro Lys Pro Arg Glu  Arg Leu Xaa 
    1520                 1525                 1530             


Leu His  Arg Ala Ala Ala Trp  Glu Pro Xaa Glu Pro  Pro Asp Gly 
    1535                 1540                 1545             


Asp Phe  Gln Xaa Glu Val 
    1550                 


<210> 1625
<211> 68
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<400> 1625
Met Glu Ser Ser Gly Xaa Pro Ser Val Xaa Leu Ile Val Gly Ser Gly 
1               5                   10                  15      


Leu Ser Cys Leu Ala Leu Ile Xaa Leu Ala Val Val Tyr Ala Ala Leu 
            20                  25                  30          


Trp Arg Tyr Ile Arg Ser Glu Arg Ser Ile Ile Leu Ile Asn Phe Cys 
        35                  40                  45              


Leu Ser Ile Ile Ser Ser Asn Ile Leu Ile Leu Val Gly Gln Xaa Gln 
    50                  55                  60                  


Xaa His Asn Lys 
65              


<210> 1626
<211> 145
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<400> 1626
Met His Leu Asn Tyr Ile Leu Phe Asn Asn Lys Asn Glu Ser Leu Gly 
1               5                   10                  15      


Xaa Trp Ser Xaa Gln Gly Cys Lys Xaa Val Leu Xaa Asp Ala Ser His 
            20                  25                  30          


Xaa Lys Cys Leu Cys Asp Arg Leu Ser Xaa Phe Ala Ile Leu Ala Gln 
        35                  40                  45              


Gln Pro Arg Glu Ile Ile Met Glu Ser Ser Gly Xaa Pro Ser Val Xaa 
    50                  55                  60                  


Leu Ile Val Gly Ser Gly Leu Ser Cys Leu Ala Leu Ile Xaa Leu Ala 
65                  70                  75                  80  


Val Val Tyr Ala Ala Leu Trp Arg Tyr Ile Arg Ser Glu Arg Ser Ile 
                85                  90                  95      


Ile Leu Ile Asn Phe Cys Leu Ser Ile Ile Ser Ser Asn Ile Leu Ile 
            100                 105                 110         


Leu Val Gly Gln Xaa Gln Xaa His Asn Lys Ser Ile Cys Xaa Xaa Xaa 
        115                 120                 125             


Xaa Ala Phe Leu His Phe Phe Phe Leu Ala Ser Phe Cys Trp Val Leu 
    130                 135                 140                 


Xaa 
145 


<210> 1627
<211> 1522
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1211)..(1211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1213)..(1213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1280)..(1280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1382)..(1382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1403)..(1403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1406)..(1406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1430)..(1430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1447)..(1447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1490)..(1490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1520)..(1520)
<223> Selenocysteine

<400> 1627
Met Lys Ala Val Arg Asn Leu Leu Ile Tyr Ile Phe Ser Xaa Tyr Leu 
1               5                   10                  15      


Leu Val Met Phe Gly Phe Asn Ala Ala Gln Asp Phe Trp Cys Ser Xaa 
            20                  25                  30          


Leu Val Lys Gly Val Ile Tyr Gly Ser Tyr Ser Val Ser Glu Met Phe 
        35                  40                  45              


Pro Lys Asn Phe Xaa Asn Cys Xaa Trp Xaa Leu Glu Asn Pro Asp Pro 
    50                  55                  60                  


Xaa Lys Tyr Ser Ile Tyr Leu Lys Phe Ser Lys Lys Asp Leu Ser Cys 
65                  70                  75                  80  


Ser Asn Phe Ser Leu Leu Ala Tyr Gln Phe Asp His Phe Ser His Glu 
                85                  90                  95      


Lys Ile Lys Asp Leu Leu Arg Lys Asn His Ser Ile Met Gln Leu Cys 
            100                 105                 110         


Asn Ser Lys Asn Ala Phe Val Phe Leu Gln Tyr Asp Lys Asn Phe Ile 
        115                 120                 125             


Gln Ile Arg Arg Val Phe Pro Xaa Asn Phe Pro Gly Leu Gln Lys Lys 
    130                 135                 140                 


Gly Glu Glu Asp Gln Lys Ser Phe Phe Glu Phe Leu Val Leu Asn Lys 
145                 150                 155                 160 


Val Ser Pro Ser Gln Phe Gly Cys His Val Leu Cys Xaa Trp Leu Glu 
                165                 170                 175     


Ser Cys Leu Lys Ser Glu Asn Gly Arg Xaa Glu Ser Cys Gly Ile Met 
            180                 185                 190         


Tyr Xaa Lys Cys Xaa Cys Pro Gln His Leu Gly Glu Trp Gly Ile Asp 
        195                 200                 205             


Asp Gln Ser Leu Ile Leu Leu Asn Asn Val Val Leu Pro Leu Asn Glu 
    210                 215                 220                 


Gln Xaa Glu Gly Cys Leu Xaa Gln Glu Leu Gln Xaa Xaa Gln Val Cys 
225                 230                 235                 240 


Asn Leu Xaa Arg Glu Ala Lys Arg Pro Pro Lys Glu Glu Phe Gly Met 
                245                 250                 255     


Met Gly Asp His Xaa Ile Lys Ser Gln Arg Pro Arg Ser Val His Glu 
            260                 265                 270         


Lys Arg Val Pro Gln Glu Gln Ala Asp Ala Ala Lys Phe Met Ala Gln 
        275                 280                 285             


Xaa Gly Glu Ser Gly Val Glu Glu Trp Ser Gln Trp Ser Xaa Cys Ser 
    290                 295                 300                 


Val Xaa Cys Gly Gln Gly Ser Gln Val Arg Xaa Arg Xaa Cys Val Ser 
305                 310                 315                 320 


Pro Tyr Gly Xaa His Cys Ser Gly Pro Leu Arg Glu Ser Arg Val Cys 
                325                 330                 335     


Asn Asn Xaa Ala Leu Cys Pro Val His Gly Val Trp Glu Glu Trp Ser 
            340                 345                 350         


Pro Trp Ser Leu Cys Ser Phe Xaa Cys Gly Arg Gly Gln Arg Xaa Arg 
        355                 360                 365             


Xaa Arg Ser Cys Xaa Pro Pro Gln Tyr Gly Gly Arg Pro Cys Glu Gly 
    370                 375                 380                 


Pro Glu Xaa His His Lys Pro Cys Asn Ile Ala Leu Cys Pro Val Asp 
385                 390                 395                 400 


Gly Gln Trp Gln Glu Trp Ser Ser Trp Ser Gln Cys Ser Val Xaa Cys 
                405                 410                 415     


Ser Asn Gly Xaa Gln Gln Arg Ser Arg Gln Cys Xaa Ala Ala Ala His 
            420                 425                 430         


Gly Gly Ser Glu Cys Arg Gly Pro Trp Ala Glu Ser Arg Glu Cys Tyr 
        435                 440                 445             


Asn Pro Glu Cys Xaa Ala Asn Gly Gln Trp Asn Gln Trp Gly His Trp 
    450                 455                 460                 


Ser Gly Cys Ser Lys Ser Cys Asp Gly Gly Trp Glu Arg Arg Ile Arg 
465                 470                 475                 480 


Xaa Cys Gln Gly Ala Val Ile Xaa Gly Gln Gln Cys Glu Gly Xaa Gly 
                485                 490                 495     


Glu Glu Val Arg Arg Cys Asn Glu Gln Arg Cys Pro Ala Pro Tyr Glu 
            500                 505                 510         


Ile Cys Pro Glu Asp Tyr Leu Met Ser Met Val Trp Lys Arg Xaa Pro 
        515                 520                 525             


Ala Gly Asp Leu Ala Phe Asn Gln Cys Pro Leu Asn Ala Xaa Gly Xaa 
    530                 535                 540                 


Xaa Ser Arg Arg Cys Ser Leu Ser Leu His Gly Val Ala Phe Trp Glu 
545                 550                 555                 560 


Gln Pro Ser Phe Ala Arg Cys Ile Ser Asn Glu Tyr Arg His Leu Gln 
                565                 570                 575     


His Ser Ile Lys Glu His Leu Ala Lys Gly Gln Arg Met Leu Ala Gly 
            580                 585                 590         


Asp Gly Met Ser Gln Val Xaa Lys Xaa Leu Leu Asp Leu Xaa Gln Arg 
        595                 600                 605             


Lys Asn Phe Tyr Ala Gly Asp Leu Leu Met Ser Val Glu Ile Leu Arg 
    610                 615                 620                 


Asn Val Xaa Asp Xaa Phe Lys Arg Ala Ser Tyr Ile Pro Ala Ser Asp 
625                 630                 635                 640 


Gly Val Gln Asn Phe Phe Gln Ile Val Ser Asn Leu Leu Asp Glu Glu 
                645                 650                 655     


Asn Lys Glu Lys Trp Glu Asp Ala Gln Gln Ile Tyr Pro Gly Ser Ile 
            660                 665                 670         


Glu Leu Met Gln Val Ile Glu Asp Phe Ile His Ile Val Gly Met Gly 
        675                 680                 685             


Met Met Asp Phe Gln Asn Ser Tyr Leu Met Xaa Gly Asn Val Val Ala 
    690                 695                 700                 


Ser Ile Gln Lys Leu Pro Ala Ala Ser Val Leu Xaa Asp Ile Asn Phe 
705                 710                 715                 720 


Pro Met Lys Gly Arg Lys Gly Met Val Asp Trp Ala Arg Asn Ser Glu 
                725                 730                 735     


Asp Arg Val Val Ile Pro Lys Ser Ile Phe Xaa Pro Val Ser Ser Lys 
            740                 745                 750         


Glu Leu Asp Glu Ser Ser Val Phe Val Leu Gly Ala Val Leu Tyr Lys 
        755                 760                 765             


Asn Leu Asp Leu Ile Leu Pro Xaa Leu Arg Asn Tyr Xaa Val Ile Asn 
    770                 775                 780                 


Ser Lys Ile Ile Val Val Xaa Ile Arg Pro Glu Pro Lys Xaa Xaa Asp 
785                 790                 795                 800 


Ser Phe Leu Glu Ile Glu Leu Ala His Leu Ala Asn Gly Xaa Leu Asn 
                805                 810                 815     


Pro Tyr Cys Val Leu Trp Asp Asp Ser Lys Xaa Asn Glu Ser Leu Gly 
            820                 825                 830         


Xaa Trp Ser Xaa Gln Gly Cys Lys Xaa Val Leu Xaa Asp Ala Ser His 
        835                 840                 845             


Xaa Lys Cys Leu Cys Asp Arg Leu Ser Xaa Phe Ala Ile Leu Ala Gln 
    850                 855                 860                 


Gln Pro Arg Glu Ile Ile Met Glu Ser Ser Gly Xaa Pro Ser Val Xaa 
865                 870                 875                 880 


Leu Ile Val Gly Ser Gly Leu Ser Cys Leu Ala Leu Ile Xaa Leu Ala 
                885                 890                 895     


Val Val Tyr Ala Ala Leu Trp Arg Tyr Ile Arg Ser Glu Arg Ser Ile 
            900                 905                 910         


Ile Leu Ile Asn Phe Cys Leu Ser Ile Ile Ser Ser Asn Ile Leu Ile 
        915                 920                 925             


Leu Val Gly Gln Xaa Gln Xaa His Asn Lys Ser Ile Cys Xaa Xaa Xaa 
    930                 935                 940                 


Xaa Ala Phe Leu His Phe Phe Phe Leu Ala Ser Phe Cys Trp Val Leu 
945                 950                 955                 960 


Xaa Glu Ala Trp Gln Ser Tyr Met Ala Val Xaa Gly Lys Ile Arg Xaa 
                965                 970                 975     


Arg Leu Ile Arg Lys Arg Phe Leu Cys Leu Gly Trp Gly Leu Pro Ala 
            980                 985                 990         


Leu Val Val Ala Xaa Ser Val Gly  Phe Xaa Arg Xaa Lys  Gly Tyr Gly 
        995                 1000                 1005             


Xaa Asp  His Tyr Cys Trp Leu  Ser Leu Glu Gly Gly  Leu Leu Tyr 
    1010                 1015                 1020             


Ala Phe  Val Gly Pro Ala Ala  Ala Val Val Leu Val  Asn Met Val 
    1025                 1030                 1035             


Ile Gly  Ile Leu Val Phe Asn  Lys Leu Val Ser Arg  Asp Gly Ile 
    1040                 1045                 1050             


Leu Asp  Lys Lys Leu Lys His  Arg Ala Gly Gln Met  Ser Glu Pro 
    1055                 1060                 1065             


His Ser  Gly Leu Xaa Leu Lys  Cys Ala Lys Cys Gly  Val Val Ser 
    1070                 1075                 1080             


Xaa Xaa  Ala Leu Ser Ala Xaa  Xaa Ala Ser Asn Ala  Met Ala Ser 
    1085                 1090                 1095             


Leu Trp  Ser Ser Cys Val Val  Leu Pro Leu Leu Ala  Leu Xaa Trp 
    1100                 1105                 1110             


Met Ser  Ala Val Leu Ala Met  Xaa Asp Lys Arg Ser  Ile Leu Phe 
    1115                 1120                 1125             


Gln Ile  Leu Phe Ala Val Phe  Asp Ser Leu Gln Gly  Phe Val Ile 
    1130                 1135                 1140             


Val Met  Val His Cys Ile Leu  Arg Arg Glu Val Gln  Asp Ala Phe 
    1145                 1150                 1155             


Arg Cys  Arg Leu Arg Asn Cys  Gln Asp Pro Ile Asn  Ala Asp Ser 
    1160                 1165                 1170             


Ser Ser  Ser Phe Pro Asn Gly  His Ala Gln Ile Met  Xaa Asp Phe 
    1175                 1180                 1185             


Glu Lys  Asp Val Asp Ile Ala  Cys Arg Ser Val Leu  His Lys Asp 
    1190                 1195                 1200             


Ile Gly  Pro Cys Arg Ala Ala  Xaa Ile Xaa Gly Xaa  Leu Ser Arg 
    1205                 1210                 1215             


Ile Ser  Leu Asn Asp Asp Glu  Glu Glu Lys Gly Xaa  Asn Pro Glu 
    1220                 1225                 1230             


Gly Leu  Ser Tyr Ser Xaa Leu  Pro Gly Asn Val Ile  Ser Lys Val 
    1235                 1240                 1245             


Ile Ile  Gln Gln Pro Xaa Gly  Leu His Met Pro Met  Ser Met Asn 
    1250                 1255                 1260             


Glu Leu  Ser Asn Pro Cys Leu  Lys Lys Glu Asn Ser  Glu Leu Arg 
    1265                 1270                 1275             


Arg Xaa  Val Tyr Leu Cys Xaa  Asp Asp Asn Leu Arg  Gly Ala Asp 
    1280                 1285                 1290             


Met Asp  Ile Val His Pro Gln  Glu Arg Met Met Glu  Ser Asp Tyr 
    1295                 1300                 1305             


Ile Val  Met Pro Arg Ser Ser  Val Asn Asn Gln Pro  Ser Met Lys 
    1310                 1315                 1320             


Glu Glu  Ser Lys Met Asn Ile  Gly Met Glu Xaa Leu  Pro His Glu 
    1325                 1330                 1335             


Arg Leu  Leu His Tyr Lys Val  Asn Pro Glu Phe Asn  Met Asn Pro 
    1340                 1345                 1350             


Pro Val  Met Asp Gln Phe Asn  Met Asn Leu Glu Gln  His Leu Ala 
    1355                 1360                 1365             


Pro Gln  Glu His Met Gln Asn  Leu Pro Phe Glu Pro  Arg Xaa Ala 
    1370                 1375                 1380             


Val Lys  Asn Phe Met Ala Ser  Glu Leu Asp Asp Asn  Ala Gly Leu 
    1385                 1390                 1395             


Ser Arg  Ser Glu Xaa Gly Ser  Xaa Ile Ser Met Ser  Ser Leu Glu 
    1400                 1405                 1410             


Arg Arg  Lys Ser Arg Tyr Ser  Asp Leu Asp Phe Glu  Lys Val Met 
    1415                 1420                 1425             


His Xaa  Arg Lys Arg His Met  Glu Leu Phe Gln Glu  Leu Asn Gln 
    1430                 1435                 1440             


Lys Phe  Gln Xaa Leu Asp Arg  Phe Arg Asp Ile Pro  Asn Xaa Ser 
    1445                 1450                 1455             


Ser Met  Glu Asn Pro Ala Pro  Asn Lys Asn Pro Trp  Asp Xaa Phe 
    1460                 1465                 1470             


Lys Asn  Pro Ser Glu Tyr Pro  His Tyr Xaa Xaa Ile  Asn Val Leu 
    1475                 1480                 1485             


Asp Xaa  Glu Ala Lys Asp Ala  Leu Glu Leu Arg Pro  Ala Glu Trp 
    1490                 1495                 1500             


Glu Lys  Cys Leu Asn Leu Pro  Leu Asp Val Gln Glu  Gly Asp Phe 
    1505                 1510                 1515             


Gln Xaa  Glu Val 
    1520         


<210> 1628
<211> 728
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<400> 1628
Met Leu Leu Pro Gln Gly Lys Glu Ala Val Glu Gly Lys Lys Cys Gln 
1               5                   10                  15      


Gly Arg Gln Arg Arg Ala Gly Leu Ser Glu Val Trp Ser Arg Lys Leu 
            20                  25                  30          


Arg Asn Glu Ser Leu Gly Xaa Trp Ser Xaa Gln Gly Cys Lys Xaa Val 
        35                  40                  45              


Leu Xaa Asp Ala Ser His Xaa Lys Cys Leu Cys Asp Arg Leu Ser Xaa 
    50                  55                  60                  


Phe Ala Ile Leu Ala Gln Gln Pro Arg Glu Ile Ile Met Glu Ser Ser 
65                  70                  75                  80  


Gly Xaa Pro Ser Val Xaa Leu Ile Val Gly Ser Gly Leu Ser Cys Leu 
                85                  90                  95      


Ala Leu Ile Xaa Leu Ala Val Val Tyr Ala Ala Leu Trp Arg Tyr Ile 
            100                 105                 110         


Arg Ser Glu Arg Ser Ile Ile Leu Ile Asn Phe Cys Leu Ser Ile Ile 
        115                 120                 125             


Ser Ser Asn Ile Leu Ile Leu Val Gly Gln Xaa Gln Xaa His Asn Lys 
    130                 135                 140                 


Ser Ile Cys Xaa Xaa Xaa Xaa Ala Phe Leu His Phe Phe Phe Leu Ala 
145                 150                 155                 160 


Ser Phe Cys Trp Val Leu Xaa Glu Ala Trp Gln Ser Tyr Met Ala Val 
                165                 170                 175     


Xaa Gly Lys Ile Arg Xaa Arg Leu Ile Arg Lys Arg Phe Leu Cys Leu 
            180                 185                 190         


Gly Trp Gly Leu Pro Ala Leu Val Val Ala Xaa Ser Val Gly Phe Xaa 
        195                 200                 205             


Arg Xaa Lys Gly Tyr Gly Xaa Asp His Tyr Cys Trp Leu Ser Leu Glu 
    210                 215                 220                 


Gly Gly Leu Leu Tyr Ala Phe Val Gly Pro Ala Ala Ala Val Val Leu 
225                 230                 235                 240 


Val Asn Met Val Ile Gly Ile Leu Val Phe Asn Lys Leu Val Ser Arg 
                245                 250                 255     


Asp Gly Ile Leu Asp Lys Lys Leu Lys His Arg Ala Gly Gln Met Ser 
            260                 265                 270         


Glu Pro His Ser Gly Leu Xaa Leu Lys Cys Ala Lys Cys Gly Val Val 
        275                 280                 285             


Ser Xaa Xaa Ala Leu Ser Ala Xaa Xaa Ala Ser Asn Ala Met Ala Ser 
    290                 295                 300                 


Leu Trp Ser Ser Cys Val Val Leu Pro Leu Leu Ala Leu Xaa Trp Met 
305                 310                 315                 320 


Ser Ala Val Leu Ala Met Xaa Asp Lys Arg Ser Ile Leu Phe Gln Ile 
                325                 330                 335     


Leu Phe Ala Val Phe Asp Ser Leu Gln Gly Phe Val Ile Val Met Val 
            340                 345                 350         


His Cys Ile Leu Arg Arg Glu Val Gln Asp Ala Phe Arg Cys Arg Leu 
        355                 360                 365             


Arg Asn Cys Gln Asp Pro Ile Asn Ala Asp Ser Ser Ser Ser Phe Pro 
    370                 375                 380                 


Asn Gly His Ala Gln Ile Met Xaa Asp Phe Glu Lys Asp Val Asp Ile 
385                 390                 395                 400 


Ala Cys Arg Ser Val Leu His Lys Asp Ile Gly Pro Cys Arg Ala Ala 
                405                 410                 415     


Xaa Ile Xaa Gly Xaa Leu Ser Arg Ile Ser Leu Asn Asp Asp Glu Glu 
            420                 425                 430         


Glu Lys Gly Xaa Asn Pro Glu Gly Leu Ser Tyr Ser Xaa Leu Pro Gly 
        435                 440                 445             


Asn Val Ile Ser Lys Val Ile Ile Gln Gln Pro Xaa Gly Leu His Met 
    450                 455                 460                 


Pro Met Ser Met Asn Glu Leu Ser Asn Pro Cys Leu Lys Lys Glu Asn 
465                 470                 475                 480 


Ser Glu Leu Arg Arg Xaa Val Tyr Leu Cys Xaa Asp Asp Asn Leu Arg 
                485                 490                 495     


Gly Ala Asp Met Asp Ile Val His Pro Gln Glu Arg Met Met Glu Ser 
            500                 505                 510         


Asp Tyr Ile Val Met Pro Arg Ser Ser Val Asn Asn Gln Pro Ser Met 
        515                 520                 525             


Lys Glu Glu Ser Lys Met Asn Ile Gly Met Glu Xaa Leu Pro His Glu 
    530                 535                 540                 


Arg Leu Leu His Tyr Lys Val Asn Pro Glu Phe Asn Met Asn Pro Pro 
545                 550                 555                 560 


Val Met Asp Gln Phe Asn Met Asn Leu Glu Gln His Leu Ala Pro Gln 
                565                 570                 575     


Glu His Met Gln Asn Leu Pro Phe Glu Pro Arg Xaa Ala Val Lys Asn 
            580                 585                 590         


Phe Met Ala Ser Glu Leu Asp Asp Asn Ala Gly Leu Ser Arg Ser Glu 
        595                 600                 605             


Xaa Gly Ser Xaa Ile Ser Met Ser Ser Leu Glu Arg Arg Lys Ser Arg 
    610                 615                 620                 


Tyr Ser Asp Leu Asp Phe Glu Lys Val Met His Xaa Arg Lys Arg His 
625                 630                 635                 640 


Met Glu Leu Phe Gln Glu Leu Asn Gln Lys Phe Gln Xaa Leu Asp Arg 
                645                 650                 655     


Phe Arg Asp Ile Pro Asn Xaa Ser Ser Met Glu Asn Pro Ala Pro Asn 
            660                 665                 670         


Lys Asn Pro Trp Asp Xaa Phe Lys Asn Pro Ser Glu Tyr Pro His Tyr 
        675                 680                 685             


Xaa Xaa Ile Asn Val Leu Asp Xaa Glu Ala Lys Asp Ala Leu Glu Leu 
    690                 695                 700                 


Arg Pro Ala Glu Trp Glu Lys Cys Leu Asn Leu Pro Leu Asp Val Gln 
705                 710                 715                 720 


Glu Gly Asp Phe Gln Xaa Glu Val 
                725             


<210> 1629
<211> 906
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (60)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<400> 1629
Met Glu Lys Leu Leu Arg Leu Cys Cys Trp Tyr Ser Trp Leu Leu Leu 
1               5                   10                  15      


Phe Tyr Tyr Asn Phe Gln Val Arg Gly Val Tyr Ser Arg Ser Gln Asp 
            20                  25                  30          


His Pro Gly Phe Gln Val Leu Ala Ser Ala Ser His Tyr Trp Pro Leu 
        35                  40                  45              


Glu Asn Val Asp Gly Ile His Glu Leu Gln Asp Xaa Xaa Gly Ala Ser 
    50                  55                  60                  


Arg Xaa His Lys Leu Xaa Val Leu Pro Ser Arg Asn Ala Xaa Phe Val 
65                  70                  75                  80  


Tyr Ser Asn Asp Ser Ala Tyr Ser Asn Leu Ser Ala Xaa Val Asp Ile 
                85                  90                  95      


Val Glu Gly Lys Val Asn Lys Gly Ile Tyr Leu Lys Glu Glu Lys Gly 
            100                 105                 110         


Val Xaa Leu Leu Tyr Tyr Gly Arg Tyr Asn Ser Ser Cys Ile Ser Lys 
        115                 120                 125             


Pro Glu Gln Cys Gly Pro Glu Gly Val Xaa Phe Ser Phe Phe Trp Lys 
    130                 135                 140                 


Xaa Gln Gly Glu Gln Ser Arg Pro Ile Pro Ser Ala Tyr Gly Gly Gln 
145                 150                 155                 160 


Val Ile Ser Asn Gly Phe Lys Val Cys Ser Ser Gly Gly Arg Gly Ser 
                165                 170                 175     


Val Glu Leu Tyr Xaa Arg Asp Asn Ser Met Xaa Trp Glu Ala Ser Phe 
            180                 185                 190         


Ser Pro Pro Gly Pro Tyr Trp Xaa His Val Leu Phe Xaa Trp Lys Ser 
        195                 200                 205             


Lys Glu Gly Leu Lys Val Tyr Val Asn Gly Xaa Leu Ser Xaa Ser Asp 
    210                 215                 220                 


Pro Ser Gly Lys Val Ser Arg Asp Tyr Gly Glu Ser Asn Val Asn Leu 
225                 230                 235                 240 


Val Ile Gly Ser Glu Gln Asp Gln Ala Lys Cys Tyr Glu Asn Gly Ala 
                245                 250                 255     


Phe Asp Glu Phe Ile Ile Trp Glu Arg Ala Leu Xaa Pro Asp Glu Ile 
            260                 265                 270         


Ala Met Tyr Phe Xaa Ala Ala Ile Gly Lys His Ala Leu Leu Ser Ser 
        275                 280                 285             


Xaa Leu Pro Ser Leu Phe Met Xaa Ser Xaa Ala Ser Pro Val Met Pro 
    290                 295                 300                 


Xaa Asp Ala Tyr His Pro Ile Ile Xaa Asn Leu Xaa Glu Glu Arg Lys 
305                 310                 315                 320 


Xaa Phe Gln Ser Pro Gly Val Ile Leu Ser Tyr Leu Gln Asn Val Ser 
                325                 330                 335     


Leu Ser Leu Pro Ser Lys Ser Leu Ser Glu Gln Xaa Ala Leu Asn Leu 
            340                 345                 350         


Xaa Lys Xaa Phe Leu Lys Ala Val Gly Glu Ile Leu Leu Leu Pro Gly 
        355                 360                 365             


Trp Ile Ala Leu Ser Glu Asp Ser Ala Val Val Leu Ser Leu Ile Asp 
    370                 375                 380                 


Xaa Ile Asp Xaa Val Met Gly His Val Ser Ser Asn Leu His Gly Ser 
385                 390                 395                 400 


Xaa Pro Gln Val Xaa Val Glu Gly Ser Ser Ala Met Ala Glu Phe Ser 
                405                 410                 415     


Val Ala Lys Ile Leu Pro Lys Xaa Val Asn Ser Ser His Tyr Arg Phe 
            420                 425                 430         


Pro Ala His Gly Gln Ser Phe Ile Gln Ile Pro His Glu Ala Phe His 
        435                 440                 445             


Arg His Ala Trp Ser Xaa Val Val Gly Leu Leu Tyr His Ser Met His 
    450                 455                 460                 


Tyr Tyr Leu Asn Asn Ile Trp Pro Ala His Xaa Lys Ile Ala Glu Ala 
465                 470                 475                 480 


Met His His Gln Asp Cys Leu Leu Phe Ala Xaa Ser His Leu Ile Ser 
                485                 490                 495     


Leu Glu Val Ser Pro Pro Pro Xaa Leu Ser Gln Asn Leu Ser Gly Ser 
            500                 505                 510         


Pro Leu Ile Xaa Val His Leu Lys His Arg Leu Xaa Arg Lys Gln His 
        515                 520                 525             


Ser Glu Ala Xaa Asn Ser Ser Asn Arg Val Phe Val Tyr Cys Ala Phe 
    530                 535                 540                 


Leu Asp Phe Ser Ser Gly Glu Gly Val Trp Ser Asn His Gly Cys Ala 
545                 550                 555                 560 


Leu Xaa Arg Gly Asn Leu Xaa Tyr Ser Val Cys Arg Cys Xaa His Leu 
                565                 570                 575     


Xaa Asn Phe Ala Ile Leu Met Gln Val Val Pro Leu Glu Leu Ala Arg 
            580                 585                 590         


Gly His Gln Val Ala Leu Ser Ser Ile Ser Tyr Val Gly Cys Ser Leu 
        595                 600                 605             


Ser Val Leu Cys Leu Val Ala Xaa Leu Val Xaa Phe Ala Val Leu Ser 
    610                 615                 620                 


Ser Val Ser Xaa Ile Arg Asn Gln Arg Tyr His Ile His Ala Asn Leu 
625                 630                 635                 640 


Ser Phe Ala Val Leu Val Ala Gln Val Leu Leu Leu Ile Ser Phe Arg 
                645                 650                 655     


Leu Glu Pro Gly Xaa Xaa Pro Cys Gln Val Met Ala Val Leu Leu His 
            660                 665                 670         


Tyr Phe Phe Leu Ser Ala Phe Ala Trp Met Leu Val Glu Gly Leu His 
        675                 680                 685             


Leu Tyr Ser Met Val Ile Lys Val Phe Gly Ser Glu Asp Ser Lys His 
    690                 695                 700                 


Arg Tyr Tyr Tyr Gly Met Gly Trp Gly Phe Pro Leu Leu Ile Cys Ile 
705                 710                 715                 720 


Ile Ser Leu Ser Phe Ala Met Asp Ser Tyr Gly Xaa Ser Asn Asn Cys 
                725                 730                 735     


Trp Leu Ser Leu Ala Ser Gly Ala Ile Trp Ala Phe Val Ala Pro Ala 
            740                 745                 750         


Leu Phe Val Ile Val Val Asn Ile Gly Ile Leu Ile Ala Val Xaa Arg 
        755                 760                 765             


Val Ile Ser Gln Ile Ser Ala Asp Asn Tyr Lys Ile His Gly Asp Pro 
    770                 775                 780                 


Ser Ala Phe Lys Leu Xaa Ala Lys Ala Val Ala Val Leu Leu Pro Ile 
785                 790                 795                 800 


Leu Gly Xaa Ser Trp Val Phe Gly Val Leu Ala Val Asn Gly Cys Ala 
                805                 810                 815     


Val Val Phe Gln Tyr Met Phe Ala Xaa Leu Asn Ser Leu Gln Gly Leu 
            820                 825                 830         


Phe Ile Phe Leu Phe His Cys Leu Leu Asn Ser Glu Val Arg Ala Ala 
        835                 840                 845             


Phe Lys His Lys Xaa Lys Val Trp Ser Leu Xaa Ser Ser Ser Ala Arg 
    850                 855                 860                 


Xaa Ser Asn Ala Lys Pro Phe His Ser Asp Leu Met Asn Gly Xaa Arg 
865                 870                 875                 880 


Pro Gly Met Ala Ser Xaa Lys Leu Ser Pro Trp Asp Lys Ser Ser His 
                885                 890                 895     


Ser Ala His Arg Val Asp Leu Ser Ala Val 
            900                 905     


<210> 1630
<211> 221
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (60)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<400> 1630
Met Glu Lys Leu Leu Arg Leu Cys Cys Trp Tyr Ser Trp Leu Leu Leu 
1               5                   10                  15      


Phe Tyr Tyr Asn Phe Gln Val Arg Gly Val Tyr Ser Arg Ser Gln Asp 
            20                  25                  30          


His Pro Gly Phe Gln Val Leu Ala Ser Ala Ser His Tyr Trp Pro Leu 
        35                  40                  45              


Glu Asn Val Asp Gly Ile His Glu Leu Gln Asp Xaa Xaa Gly Asp Ile 
    50                  55                  60                  


Val Glu Gly Lys Val Asn Lys Gly Ile Tyr Leu Lys Glu Glu Lys Gly 
65                  70                  75                  80  


Val Xaa Leu Leu Tyr Tyr Gly Arg Tyr Asn Ser Ser Cys Ile Ser Lys 
                85                  90                  95      


Pro Glu Gln Cys Gly Pro Glu Gly Pro Tyr Trp Xaa His Val Leu Phe 
            100                 105                 110         


Xaa Trp Lys Ser Lys Glu Gly Leu Lys Val Tyr Val Asn Gly Xaa Leu 
        115                 120                 125             


Ser Xaa Ser Asp Pro Ser Gly Lys Val Ser Arg Asp Tyr Gly Glu Ser 
    130                 135                 140                 


Asn Val Asn Leu Val Ile Gly Ser Glu Gln Asp Gln Ala Lys Cys Tyr 
145                 150                 155                 160 


Glu Asn Gly Ala Phe Asp Glu Phe Ile Ile Trp Glu Arg Ala Leu Xaa 
                165                 170                 175     


Pro Asp Glu Ile Ala Met Tyr Phe Xaa Ala Ala Ile Gly Lys His Ala 
            180                 185                 190         


Leu Leu Ser Ser Xaa Leu Pro Ser Leu Phe Met Xaa Ser Xaa Ala Ser 
        195                 200                 205             


Pro Val Met Pro Xaa Asp Ala Tyr His Pro Ile Ile Xaa 
    210                 215                 220     


<210> 1631
<211> 874
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (60)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<400> 1631
Met Glu Lys Leu Leu Arg Leu Cys Cys Trp Tyr Ser Trp Leu Leu Leu 
1               5                   10                  15      


Phe Tyr Tyr Asn Phe Gln Val Arg Gly Val Tyr Ser Arg Ser Gln Asp 
            20                  25                  30          


His Pro Gly Phe Gln Val Leu Ala Ser Ala Ser His Tyr Trp Pro Leu 
        35                  40                  45              


Glu Asn Val Asp Gly Ile His Glu Leu Gln Asp Xaa Xaa Gly Asp Ile 
    50                  55                  60                  


Val Glu Gly Lys Val Asn Lys Gly Ile Tyr Leu Lys Glu Glu Lys Gly 
65                  70                  75                  80  


Val Xaa Leu Leu Tyr Tyr Gly Arg Tyr Asn Ser Ser Cys Ile Ser Lys 
                85                  90                  95      


Pro Glu Gln Cys Gly Pro Glu Gly Val Xaa Phe Ser Phe Phe Trp Lys 
            100                 105                 110         


Xaa Gln Gly Glu Gln Ser Arg Pro Ile Pro Ser Ala Tyr Gly Gly Gln 
        115                 120                 125             


Val Ile Ser Asn Gly Phe Lys Val Cys Ser Ser Gly Gly Arg Gly Ser 
    130                 135                 140                 


Val Glu Leu Tyr Xaa Arg Asp Asn Ser Met Xaa Trp Glu Ala Ser Phe 
145                 150                 155                 160 


Ser Pro Pro Gly Pro Tyr Trp Xaa His Val Leu Phe Xaa Trp Lys Ser 
                165                 170                 175     


Lys Glu Gly Leu Lys Val Tyr Val Asn Gly Xaa Leu Ser Xaa Ser Asp 
            180                 185                 190         


Pro Ser Gly Lys Val Ser Arg Asp Tyr Gly Glu Ser Asn Val Asn Leu 
        195                 200                 205             


Val Ile Gly Ser Glu Gln Asp Gln Ala Lys Cys Tyr Glu Asn Gly Ala 
    210                 215                 220                 


Phe Asp Glu Phe Ile Ile Trp Glu Arg Ala Leu Xaa Pro Asp Glu Ile 
225                 230                 235                 240 


Ala Met Tyr Phe Xaa Ala Ala Ile Gly Lys His Ala Leu Leu Ser Ser 
                245                 250                 255     


Xaa Leu Pro Ser Leu Phe Met Xaa Ser Xaa Ala Ser Pro Val Met Pro 
            260                 265                 270         


Xaa Asp Ala Tyr His Pro Ile Ile Xaa Asn Leu Xaa Glu Glu Arg Lys 
        275                 280                 285             


Xaa Phe Gln Ser Pro Gly Val Ile Leu Ser Tyr Leu Gln Asn Val Ser 
    290                 295                 300                 


Leu Ser Leu Pro Ser Lys Ser Leu Ser Glu Gln Xaa Ala Leu Asn Leu 
305                 310                 315                 320 


Xaa Lys Xaa Phe Leu Lys Ala Val Gly Glu Ile Leu Leu Leu Pro Gly 
                325                 330                 335     


Trp Ile Ala Leu Ser Glu Asp Ser Ala Val Val Leu Ser Leu Ile Asp 
            340                 345                 350         


Xaa Ile Asp Xaa Val Met Gly His Val Ser Ser Asn Leu His Gly Ser 
        355                 360                 365             


Xaa Pro Gln Val Xaa Val Glu Gly Ser Ser Ala Met Ala Glu Phe Ser 
    370                 375                 380                 


Val Ala Lys Ile Leu Pro Lys Xaa Val Asn Ser Ser His Tyr Arg Phe 
385                 390                 395                 400 


Pro Ala His Gly Gln Ser Phe Ile Gln Ile Pro His Glu Ala Phe His 
                405                 410                 415     


Arg His Ala Trp Ser Xaa Val Val Gly Leu Leu Tyr His Ser Met His 
            420                 425                 430         


Tyr Tyr Leu Asn Asn Ile Trp Pro Ala His Xaa Lys Ile Ala Glu Ala 
        435                 440                 445             


Met His His Gln Asp Cys Leu Leu Phe Ala Xaa Ser His Leu Ile Ser 
    450                 455                 460                 


Leu Glu Val Ser Pro Pro Pro Xaa Leu Ser Gln Asn Leu Ser Gly Ser 
465                 470                 475                 480 


Pro Leu Ile Xaa Val His Leu Lys His Arg Leu Xaa Arg Lys Gln His 
                485                 490                 495     


Ser Glu Ala Xaa Asn Ser Ser Asn Arg Val Phe Val Tyr Cys Ala Phe 
            500                 505                 510         


Leu Asp Phe Ser Ser Gly Glu Gly Val Trp Ser Asn His Gly Cys Ala 
        515                 520                 525             


Leu Xaa Arg Gly Asn Leu Xaa Tyr Ser Val Cys Arg Cys Xaa His Leu 
    530                 535                 540                 


Xaa Asn Phe Ala Ile Leu Met Gln Val Val Pro Leu Glu Leu Ala Arg 
545                 550                 555                 560 


Gly His Gln Val Ala Leu Ser Ser Ile Ser Tyr Val Gly Cys Ser Leu 
                565                 570                 575     


Ser Val Leu Cys Leu Val Ala Xaa Leu Val Xaa Phe Ala Val Leu Ser 
            580                 585                 590         


Ser Val Ser Xaa Ile Arg Asn Gln Arg Tyr His Ile His Ala Asn Leu 
        595                 600                 605             


Ser Phe Ala Val Leu Val Ala Gln Val Leu Leu Leu Ile Ser Phe Arg 
    610                 615                 620                 


Leu Glu Pro Gly Xaa Xaa Pro Cys Gln Val Met Ala Val Leu Leu His 
625                 630                 635                 640 


Tyr Phe Phe Leu Ser Ala Phe Ala Trp Met Leu Val Glu Gly Leu His 
                645                 650                 655     


Leu Tyr Ser Met Val Ile Lys Val Phe Gly Ser Glu Asp Ser Lys His 
            660                 665                 670         


Arg Tyr Tyr Tyr Gly Met Gly Trp Gly Phe Pro Leu Leu Ile Cys Ile 
        675                 680                 685             


Ile Ser Leu Ser Phe Ala Met Asp Ser Tyr Gly Xaa Ser Asn Asn Cys 
    690                 695                 700                 


Trp Leu Ser Leu Ala Ser Gly Ala Ile Trp Ala Phe Val Ala Pro Ala 
705                 710                 715                 720 


Leu Phe Val Ile Val Val Asn Ile Gly Ile Leu Ile Ala Val Xaa Arg 
                725                 730                 735     


Val Ile Ser Gln Ile Ser Ala Asp Asn Tyr Lys Ile His Gly Asp Pro 
            740                 745                 750         


Ser Ala Phe Lys Leu Xaa Ala Lys Ala Val Ala Val Leu Leu Pro Ile 
        755                 760                 765             


Leu Gly Xaa Ser Trp Val Phe Gly Val Leu Ala Val Asn Gly Cys Ala 
    770                 775                 780                 


Val Val Phe Gln Tyr Met Phe Ala Xaa Leu Asn Ser Leu Gln Gly Leu 
785                 790                 795                 800 


Phe Ile Phe Leu Phe His Cys Leu Leu Asn Ser Glu Val Arg Ala Ala 
                805                 810                 815     


Phe Lys His Lys Xaa Lys Val Trp Ser Leu Xaa Ser Ser Ser Ala Arg 
            820                 825                 830         


Xaa Ser Asn Ala Lys Pro Phe His Ser Asp Leu Met Asn Gly Xaa Arg 
        835                 840                 845             


Pro Gly Met Ala Ser Xaa Lys Leu Ser Pro Trp Asp Lys Ser Ser His 
    850                 855                 860                 


Ser Ala His Arg Val Asp Leu Ser Ala Val 
865                 870                 


<210> 1632
<211> 393
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<400> 1632
Met His Arg Val Cys Phe Leu Ser Phe Gln Xaa Arg Lys Gln His Ser 
1               5                   10                  15      


Glu Ala Xaa Asn Ser Ser Asn Arg Val Phe Val Tyr Cys Ala Phe Leu 
            20                  25                  30          


Asp Phe Ser Ser Gly Glu Gly Val Trp Ser Asn His Gly Cys Ala Leu 
        35                  40                  45              


Xaa Arg Gly Asn Leu Xaa Tyr Ser Val Cys Arg Cys Xaa His Leu Xaa 
    50                  55                  60                  


Asn Phe Ala Ile Leu Met Gln Val Val Pro Leu Glu Leu Ala Arg Gly 
65                  70                  75                  80  


His Gln Val Ala Leu Ser Ser Ile Ser Tyr Val Gly Cys Ser Leu Ser 
                85                  90                  95      


Val Leu Cys Leu Val Ala Xaa Leu Val Xaa Phe Ala Val Leu Ser Ser 
            100                 105                 110         


Val Ser Xaa Ile Arg Asn Gln Arg Tyr His Ile His Ala Asn Leu Ser 
        115                 120                 125             


Phe Ala Val Leu Val Ala Gln Val Leu Leu Leu Ile Ser Phe Arg Leu 
    130                 135                 140                 


Glu Pro Gly Xaa Xaa Pro Cys Gln Val Met Ala Val Leu Leu His Tyr 
145                 150                 155                 160 


Phe Phe Leu Ser Ala Phe Ala Trp Met Leu Val Glu Gly Leu His Leu 
                165                 170                 175     


Tyr Ser Met Val Ile Lys Val Phe Gly Ser Glu Asp Ser Lys His Arg 
            180                 185                 190         


Tyr Tyr Tyr Gly Met Gly Trp Gly Phe Pro Leu Leu Ile Cys Ile Ile 
        195                 200                 205             


Ser Leu Ser Phe Ala Met Asp Ser Tyr Gly Xaa Ser Asn Asn Cys Trp 
    210                 215                 220                 


Leu Ser Leu Ala Ser Gly Ala Ile Trp Ala Phe Val Ala Pro Ala Leu 
225                 230                 235                 240 


Phe Val Ile Val Val Asn Ile Gly Ile Leu Ile Ala Val Xaa Arg Val 
                245                 250                 255     


Ile Ser Gln Ile Ser Ala Asp Asn Tyr Lys Ile His Gly Asp Pro Ser 
            260                 265                 270         


Ala Phe Lys Leu Xaa Ala Lys Ala Val Ala Val Leu Leu Pro Ile Leu 
        275                 280                 285             


Gly Xaa Ser Trp Val Phe Gly Val Leu Ala Val Asn Gly Cys Ala Val 
    290                 295                 300                 


Val Phe Gln Tyr Met Phe Ala Xaa Leu Asn Ser Leu Gln Gly Leu Phe 
305                 310                 315                 320 


Ile Phe Leu Phe His Cys Leu Leu Asn Ser Glu Val Arg Ala Ala Phe 
                325                 330                 335     


Lys His Lys Xaa Lys Val Trp Ser Leu Xaa Ser Ser Ser Ala Arg Xaa 
            340                 345                 350         


Ser Asn Ala Lys Pro Phe His Ser Asp Leu Met Asn Gly Xaa Arg Pro 
        355                 360                 365             


Gly Met Ala Ser Xaa Lys Leu Ser Pro Trp Asp Lys Ser Ser His Ser 
    370                 375                 380                 


Ala His Arg Val Asp Leu Ser Ala Val 
385                 390             


<210> 1633
<211> 345
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<400> 1633
Met Gln Val Val Pro Leu Glu Leu Ala Arg Gly His Gln Val Ala Leu 
1               5                   10                  15      


Ser Ser Ile Ser Tyr Val Gly Cys Ser Leu Ser Val Leu Cys Leu Val 
            20                  25                  30          


Ala Xaa Leu Val Xaa Phe Ala Val Leu Ser Ser Val Ser Xaa Ile Arg 
        35                  40                  45              


Asn Gln Arg Tyr His Ile His Ala Asn Leu Ser Phe Ala Val Leu Val 
    50                  55                  60                  


Ala Gln Val Leu Leu Leu Ile Ser Phe Arg Leu Glu Pro Gly Xaa Xaa 
65                  70                  75                  80  


Pro Cys Gln Val Met Ala Val Leu Leu His Tyr Phe Phe Leu Ser Ala 
                85                  90                  95      


Phe Ala Trp Met Leu Val Glu Gly Leu His Leu Tyr Ser Met Val Ile 
            100                 105                 110         


Lys Val Phe Gly Ser Glu Asp Ser Lys His Arg Tyr Tyr Tyr Gly Met 
        115                 120                 125             


Gly Trp Gly Phe Pro Leu Leu Ile Cys Ile Ile Ser Leu Ser Phe Ala 
    130                 135                 140                 


Met Asp Ser Tyr Gly Xaa Ser Asn Asn Cys Trp Leu Ser Leu Ala Ser 
145                 150                 155                 160 


Gly Ala Ile Trp Ala Phe Val Ala Pro Ala Leu Phe Val Ile Val Val 
                165                 170                 175     


Asn Ile Gly Ile Leu Ile Ala Val Xaa Arg Val Ile Ser Gln Ile Ser 
            180                 185                 190         


Ala Asp Asn Tyr Lys Ile His Gly Asp Pro Ser Ala Phe Lys Leu Xaa 
        195                 200                 205             


Ala Lys Ala Val Ala Val Leu Leu Pro Ile Leu Gly Xaa Ser Trp Val 
    210                 215                 220                 


Phe Gly Val Leu Ala Val Asn Gly Cys Ala Val Val Phe Gln Tyr Met 
225                 230                 235                 240 


Phe Ala Xaa Leu Asn Ser Leu Gln Gly Leu Phe Ile Phe Leu Phe His 
                245                 250                 255     


Cys Leu Leu Asn Ser Glu Ala Arg Trp Ala Lys Glu Gly Arg Ala Glu 
            260                 265                 270         


Ser Leu Ser Arg Met Val Ala Gly Gln Lys Gly Cys Met Ile Xaa Lys 
        275                 280                 285             


Pro Ser Asp Pro Leu Ile Ala Xaa Pro Ser Asp Pro Leu Gln Gly Leu 
    290                 295                 300                 


Arg Trp Ile Pro Val Ala Gly Arg Gln Cys Ser His Gly Ser Pro Pro 
305                 310                 315                 320 


Ala His Pro Pro Ala Cys Pro Pro Arg Ile Cys Leu Phe Ala Ser Leu 
                325                 330                 335     


Ser His Ser Pro Arg Asp Ile His Cys 
            340                 345 


<210> 1634
<211> 156
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 1634
Met Gln Val Val Pro Leu Glu Val Asn Ile Gly Ile Leu Ile Ala Val 
1               5                   10                  15      


Xaa Arg Val Ile Ser Gln Ile Ser Ala Asp Asn Tyr Lys Ile His Gly 
            20                  25                  30          


Asp Pro Ser Ala Phe Lys Leu Xaa Ala Lys Ala Val Ala Val Leu Leu 
        35                  40                  45              


Pro Ile Leu Gly Xaa Ser Trp Val Phe Gly Val Leu Ala Val Asn Gly 
    50                  55                  60                  


Cys Ala Val Val Phe Gln Tyr Met Phe Ala Xaa Leu Asn Ser Leu Gln 
65                  70                  75                  80  


Gly Leu Phe Ile Phe Leu Phe His Cys Leu Leu Asn Ser Glu Val Arg 
                85                  90                  95      


Ala Ala Phe Lys His Lys Xaa Lys Val Trp Ser Leu Xaa Ser Ser Ser 
            100                 105                 110         


Ala Arg Xaa Ser Asn Ala Lys Pro Phe His Ser Asp Leu Met Asn Gly 
        115                 120                 125             


Xaa Arg Pro Gly Met Ala Ser Xaa Lys Leu Ser Pro Trp Asp Lys Ser 
    130                 135                 140                 


Ser His Ser Ala His Arg Val Asp Leu Ser Ala Val 
145                 150                 155     


<210> 1635
<211> 41
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<400> 1635
Phe Leu Val Ala Phe Ser Trp Met Leu Val Glu Gly Leu Leu Leu Trp 
1               5                   10                  15      


Arg Lys Val Val Ala Val Ser Met His Pro Gly Pro Gly Met Arg Leu 
            20                  25                  30          


Tyr His Ala Xaa Gly Trp Gly Pro Arg 
        35                  40      


<210> 1636
<211> 972
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<400> 1636
Xaa Ser Gly Val Ser Leu Gly Pro Pro Pro Xaa Pro Gln Val Asn Gln 
1               5                   10                  15      


Gly Xaa Leu Gly Pro Gln Val Ala Pro Val Ala Ala Gly Glu Val Val 
            20                  25                  30          


Lys Xaa Ala Gly Gly Val Cys Lys Phe Ser Gly Gln Arg Leu Ser Trp 
        35                  40                  45              


Trp Gln Ala Gln Glu Ser Cys Glu Gln Gln Phe Gly His Leu Ala Leu 
    50                  55                  60                  


Gln Pro Pro Asp Gly Val Leu Ala Ser Arg Leu Arg Asp Pro Val Trp 
65                  70                  75                  80  


Val Gly Gln Arg Glu Ala Pro Leu Arg Arg Pro Pro Gln Arg Arg Ala 
                85                  90                  95      


Arg Xaa Xaa Ala Val Leu Val Phe Asp Glu Arg Xaa Ala Asp Arg Ala 
            100                 105                 110         


Ala Arg Leu Arg Ser Pro Leu Pro Glu Leu Ala Ala Leu Xaa Ala Cys 
        115                 120                 125             


Xaa His Val Gln Trp Asp Cys Ala Ser Pro Asp Pro Ala Ala Leu Phe 
    130                 135                 140                 


Ser Val Ala Ala Pro Ala Leu Pro Asn Ala Leu Gln Leu Arg Ala Phe 
145                 150                 155                 160 


Ala Glu Pro Gly Gly Val Val Arg Ala Ala Leu Val Val Arg Gly Gln 
                165                 170                 175     


His Ala Pro Phe Leu Ala Ala Phe Arg Ala Asp Gly Arg Trp His His 
            180                 185                 190         


Val Cys Ala Xaa Trp Glu Gln Arg Gly Gly Arg Trp Ala Leu Phe Ser 
        195                 200                 205             


Asp Gly Arg Arg Arg Ala Gly Ala Arg Gly Leu Gly Ala Gly His Pro 
    210                 215                 220                 


Val Pro Ser Gly Gly Ile Leu Val Leu Gly Gln Asp Gln Asp Ser Leu 
225                 230                 235                 240 


Gly Gly Gly Phe Ser Val Arg His Ala Leu Ser Gly Asn Leu Xaa Asp 
                245                 250                 255     


Phe His Leu Trp Ala Arg Ala Leu Ser Pro Ala Gln Leu His Arg Ala 
            260                 265                 270         


Arg Ala Cys Ala Pro Pro Ser Glu Gly Leu Leu Phe Arg Trp Asp Pro 
        275                 280                 285             


Gly Ala Leu Asp Val Xaa Pro Ser Leu Leu Pro Xaa Val Trp Val Arg 
    290                 295                 300                 


Leu Leu Cys Pro Val Pro Ser Glu Glu Cys Pro Xaa Trp Asn Pro Gly 
305                 310                 315                 320 


Pro Arg Ser Glu Gly Ser Glu Leu Cys Leu Glu Pro Gln Pro Phe Leu 
                325                 330                 335     


Cys Cys Tyr Arg Xaa Glu Pro Tyr Arg Arg Leu Gln Asp Ala Gln Ser 
            340                 345                 350         


Trp Pro Gly Gln Asp Val Ile Ser Arg Val Asn Ala Leu Ala Asn Asp 
        355                 360                 365             


Ile Val Leu Leu Pro Asp Pro Leu Ser Glu Val His Gly Ala Leu Ser 
    370                 375                 380                 


Pro Ala Glu Ala Ser Ser Phe Leu Gly Leu Leu Glu His Val Leu Ala 
385                 390                 395                 400 


Met Glu Met Ala Pro Leu Gly Pro Ala Ala Leu Leu Ala Val Val Arg 
                405                 410                 415     


Phe Leu Lys Arg Val Val Ala Leu Gly Ala Gly Asp Pro Glu Leu Leu 
            420                 425                 430         


Leu Xaa Gly Pro Trp Glu Gln Leu Ser Gln Gly Val Val Ser Val Ala 
        435                 440                 445             


Ser Leu Val Leu Glu Glu Gln Val Ala Asp Xaa Trp Leu Ser Leu Arg 
    450                 455                 460                 


Glu Val Ile Gly Gly Pro Met Ala Leu Val Ala Ser Val Gln Arg Leu 
465                 470                 475                 480 


Ala Pro Leu Leu Ser Xaa Ser Met Xaa Ser Glu Arg Pro Arg Met Arg 
                485                 490                 495     


Ile Gln His Arg His Ala Gly Leu Glu Val Arg Ser Leu Arg Leu Arg 
            500                 505                 510         


Glu Ala Ser Xaa Arg Gly Cys Leu Phe Xaa Met Pro Gly Gly Arg Pro 
        515                 520                 525             


Glu Gly Pro Gly His Ile His Ile Pro Ala Ser Glu Val Arg Arg Leu 
    530                 535                 540                 


Leu Arg Lys Gly Leu Ser Gly Val Xaa Val Ile His Ser Trp Phe Xaa 
545                 550                 555                 560 


Ser Arg Val Phe Gln His Xaa Leu Glu Gly Pro Asp Leu Glu Pro Gln 
                565                 570                 575     


Ala Pro Ala Ser Ser Glu Glu Ala Asn Arg Val Gln Arg Phe Leu Ser 
            580                 585                 590         


Xaa Gln Val Gly Ser Ala Ile Ile Ser Ser Glu Val Trp Asp Val Xaa 
        595                 600                 605             


Gly Glu Val Asn Val Ala Met Xaa Phe His Leu Gln His Arg Ala Gln 
    610                 615                 620                 


Ser Pro Leu Phe Pro Pro His Pro Pro Ser Pro Tyr Xaa Gly Gly Ala 
625                 630                 635                 640 


Trp Ala Xaa Xaa Gly Cys Ser Val Ala Ala Leu Tyr Leu Asp Ser Xaa 
                645                 650                 655     


Ala Cys Phe Cys Asn His Ser Xaa Ser Phe Ala Ile Leu Leu Gln Ile 
            660                 665                 670         


Tyr Glu Val Gln Arg Gly Pro Glu Glu Glu Ser Leu Leu Arg Xaa Leu 
        675                 680                 685             


Ser Phe Val Gly Cys Gly Val Ser Phe Cys Ala Leu Xaa Xaa Xaa Phe 
    690                 695                 700                 


Leu Leu Phe Leu Val Ala Gly Val Pro Lys Ser Glu Arg Xaa Xaa Val 
705                 710                 715                 720 


His Lys Asn Leu Xaa Phe Ser Leu Ala Ser Ala Glu Gly Phe Leu Met 
                725                 730                 735     


Xaa Ser Glu Trp Ala Lys Ala Asn Glu Val Ala Cys Val Ala Val Xaa 
            740                 745                 750         


Val Ala Met His Phe Leu Phe Leu Val Ala Phe Ser Trp Met Leu Val 
        755                 760                 765             


Glu Gly Leu Leu Leu Trp Arg Lys Val Val Ala Val Ser Met His Pro 
    770                 775                 780                 


Gly Pro Gly Met Arg Leu Tyr His Ala Xaa Gly Trp Gly Val Pro Val 
785                 790                 795                 800 


Gly Ile Val Ala Val Xaa Leu Ala Met Leu Pro His Asp Tyr Val Ala 
                805                 810                 815     


Pro Gly His Cys Trp Leu Asn Val His Xaa Asn Ala Ile Trp Ala Phe 
            820                 825                 830         


Val Gly Pro Val Leu Phe Val Leu Xaa Ala Asn Xaa Cys Ile Leu Ala 
        835                 840                 845             


Arg Val Val Met Ile Xaa Val Ser Ser Ala Arg Arg Arg Ala Arg Met 
    850                 855                 860                 


Leu Ser Pro Gln Pro Cys Leu Gln Gln Gln Ile Trp Xaa Gln Ile Trp 
865                 870                 875                 880 


Ala Xaa Val Lys Pro Val Leu Val Leu Leu Pro Val Leu Gly Leu Xaa 
                885                 890                 895     


Trp Leu Ala Gly Ile Leu Val His Leu Ser Pro Ala Trp Ala Tyr Ala 
            900                 905                 910         


Ala Val Gly Leu Asn Ser Ile Gln Gly Leu Tyr Ile Phe Leu Val Tyr 
        915                 920                 925             


Ala Ala Cys Asn Glu Glu Val Arg Ser Ala Leu Gln Arg Met Ala Glu 
    930                 935                 940                 


Lys Lys Val Ala Glu Gly Pro Met Ala Leu Glu Leu Pro Gln His Ser 
945                 950                 955                 960 


Pro Pro Leu Gln Xaa Arg Arg Asp Arg Leu Trp Asn 
                965                 970         


<210> 1637
<211> 319
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<400> 1637
Cys Arg Asp Ser Xaa Leu Cys Pro Ala Tyr Ala Xaa Cys Xaa Asn Xaa 
1               5                   10                  15      


Val Asp Ser Tyr Tyr Cys Ala Cys Lys Gln Gly Phe Leu Ser Ser Asn 
            20                  25                  30          


Gly Gln Asn His Phe Lys Asp Pro Gly Val Arg Cys Lys Asp Ile Asp 
        35                  40                  45              


Glu Cys Ser Gln Ser Pro Gln Pro Cys Gly Pro Asn Ser Ser Cys Lys 
    50                  55                  60                  


Asn Leu Ser Gly Arg Tyr Lys Cys Ser Cys Leu Asp Gly Phe Ser Ser 
65                  70                  75                  80  


Pro Xaa Gly Asn Asp Trp Val Pro Gly Lys Pro Gly Asn Phe Ser Cys 
                85                  90                  95      


Xaa Asp Ile Asn Glu Cys Leu Xaa Ser Ser Val Cys Pro Glu His Ser 
            100                 105                 110         


Asp Cys Val Asn Ser Met Gly Ser Tyr Ser Cys Ser Cys Gln Val Gly 
        115                 120                 125             


Phe Ile Ser Arg Asn Ser Xaa Cys Glu Asp Val Asp Glu Cys Ala Asp 
    130                 135                 140                 


Pro Arg Ala Cys Pro Glu His Ala Xaa Cys Asn Asn Xaa Val Gly Asn 
145                 150                 155                 160 


Tyr Ser Cys Phe Cys Asn Pro Gly Phe Glu Ser Ser Ser Gly His Leu 
                165                 170                 175     


Ser Phe Gln Gly Leu Lys Ala Ser Cys Glu Asp Ile Asp Glu Cys Xaa 
            180                 185                 190         


Glu Met Cys Pro Ile Asn Ser Xaa Cys Xaa Asn Xaa Pro Gly Ser Tyr 
        195                 200                 205             


Phe Cys Xaa Cys His Pro Gly Phe Ala Pro Ser Asn Gly Gln Leu Asn 
    210                 215                 220                 


Phe Xaa Asp Gln Gly Val Glu Cys Arg Gly Val Leu Phe Lys Cys Lys 
225                 230                 235                 240 


Glu Asp Val Ile Pro Asp Asn Lys Gln Ile Gln Gln Cys Gln Glu Gly 
                245                 250                 255     


Xaa Ala Val Lys Pro Ala Tyr Val Ser Phe Cys Ala Gln Ile Asn Asn 
            260                 265                 270         


Ile Phe Ser Val Leu Asp Lys Val Cys Glu Asn Lys Xaa Xaa Val Val 
        275                 280                 285             


Ser Leu Lys Asn Xaa Xaa Glu Ser Phe Val Pro Val Leu Lys Gln Ile 
    290                 295                 300                 


Ser Xaa Trp Xaa Lys Phe Xaa Lys Glu Glu Xaa Ser Ser Leu Ala 
305                 310                 315                 


<210> 1638
<211> 709
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<400> 1638
Met Arg Gly Phe Asn Leu Leu Leu Phe Trp Gly Cys Cys Val Met His 
1               5                   10                  15      


Ser Trp Glu Gly His Ile Arg Pro Xaa Arg Lys Pro Asn Xaa Lys Gly 
            20                  25                  30          


Asn Asn Cys Arg Asp Ser Xaa Leu Cys Pro Ala Tyr Ala Xaa Cys Xaa 
        35                  40                  45              


Asn Xaa Val Asp Ser Tyr Tyr Cys Ala Cys Lys Gln Gly Phe Leu Ser 
    50                  55                  60                  


Ser Asn Gly Gln Asn His Phe Lys Asp Pro Gly Val Arg Cys Lys Asp 
65                  70                  75                  80  


Ile Asp Glu Cys Ser Gln Ser Pro Gln Pro Cys Gly Pro Asn Ser Ser 
                85                  90                  95      


Cys Lys Asn Leu Ser Gly Arg Tyr Lys Cys Ser Cys Leu Asp Gly Phe 
            100                 105                 110         


Ser Ser Pro Xaa Gly Asn Asp Trp Val Pro Gly Lys Pro Gly Asn Phe 
        115                 120                 125             


Ser Cys Xaa Asp Ile Asn Glu Cys Leu Xaa Ser Arg Val Leu Phe Lys 
    130                 135                 140                 


Cys Lys Glu Asp Val Ile Pro Asp Asn Lys Gln Ile Gln Gln Cys Gln 
145                 150                 155                 160 


Glu Gly Xaa Ala Val Lys Pro Ala Tyr Val Ser Phe Cys Ala Gln Ile 
                165                 170                 175     


Asn Asn Ile Phe Ser Val Leu Asp Lys Val Cys Glu Asn Lys Xaa Xaa 
            180                 185                 190         


Val Val Ser Leu Lys Asn Xaa Xaa Glu Ser Phe Val Pro Val Leu Lys 
        195                 200                 205             


Gln Ile Ser Xaa Trp Xaa Lys Phe Xaa Lys Glu Glu Xaa Ser Ser Leu 
    210                 215                 220                 


Ala Xaa Val Phe Leu Glu Ser Val Glu Ser Met Xaa Leu Ala Ser Phe 
225                 230                 235                 240 


Trp Lys Pro Ser Ala Asn Ile Xaa Pro Ala Val Arg Xaa Glu Tyr Leu 
                245                 250                 255     


Asp Ile Glu Ser Lys Val Ile Asn Lys Glu Cys Ser Glu Glu Asn Val 
            260                 265                 270         


Xaa Leu Asp Leu Val Ala Lys Gly Asp Lys Met Lys Ile Gly Cys Ser 
        275                 280                 285             


Xaa Ile Glu Glu Ser Glu Ser Xaa Glu Xaa Xaa Gly Val Ala Phe Val 
    290                 295                 300                 


Ser Phe Val Gly Met Glu Ser Val Leu Asn Glu Arg Phe Phe Lys Asp 
305                 310                 315                 320 


His Gln Ala Pro Leu Xaa Xaa Ser Glu Ile Lys Leu Lys Met Asn Ser 
                325                 330                 335     


Arg Val Val Gly Gly Ile Met Xaa Gly Glu Lys Lys Asp Gly Phe Ser 
            340                 345                 350         


Asp Pro Ile Ile Tyr Xaa Leu Glu Asn Ile Gln Pro Lys Gln Lys Phe 
        355                 360                 365             


Glu Arg Pro Ile Cys Val Ser Trp Ser Xaa Asp Val Lys Gly Gly Arg 
    370                 375                 380                 


Trp Xaa Ser Phe Gly Cys Val Ile Leu Glu Ala Ser Glu Xaa Tyr Xaa 
385                 390                 395                 400 


Ile Cys Ser Cys Asn Gln Met Ala Asn Leu Ala Val Ile Met Ala Ser 
                405                 410                 415     


Gly Glu Leu Xaa Met Asp Phe Ser Leu Tyr Ile Ile Ser His Val Gly 
            420                 425                 430         


Ile Ile Ile Ser Leu Val Cys Leu Val Leu Ala Ile Ala Xaa Phe Leu 
        435                 440                 445             


Leu Cys Arg Ser Ile Arg Asn His Asn Xaa Tyr Leu His Leu His Leu 
    450                 455                 460                 


Cys Val Cys Leu Leu Leu Ala Lys Xaa Leu Phe Leu Ala Gly Ile His 
465                 470                 475                 480 


Lys Xaa Asp Asn Lys Met Gly Cys Ala Ile Ile Ala Gly Phe Leu His 
                485                 490                 495     


Tyr Leu Phe Leu Ala Cys Phe Phe Trp Met Leu Val Glu Ala Val Ile 
            500                 505                 510         


Leu Phe Leu Met Val Arg Asn Leu Lys Val Val Asn Tyr Phe Ser Ser 
        515                 520                 525             


Arg Asn Ile Lys Met Leu His Ile Cys Ala Phe Gly Tyr Gly Leu Pro 
    530                 535                 540                 


Met Leu Val Val Val Ile Ser Ala Ser Val Gln Pro Gln Gly Tyr Gly 
545                 550                 555                 560 


Met His Asn Arg Cys Trp Leu Asn Xaa Glu Xaa Gly Phe Ile Trp Ser 
                565                 570                 575     


Phe Leu Gly Pro Val Cys Xaa Val Ile Val Ile Asn Ser Leu Leu Leu 
            580                 585                 590         


Xaa Trp Xaa Leu Trp Ile Leu Arg Gln Arg Leu Ser Ser Val Asn Ala 
        595                 600                 605             


Glu Val Ser Xaa Leu Lys Asp Xaa Arg Leu Leu Xaa Phe Lys Ala Phe 
    610                 615                 620                 


Ala Gln Leu Phe Ile Leu Gly Cys Ser Trp Val Leu Gly Ile Phe Gln 
625                 630                 635                 640 


Ile Gly Pro Val Ala Gly Val Met Ala Tyr Leu Phe Xaa Ile Ile Asn 
                645                 650                 655     


Ser Leu Gln Gly Ala Phe Ile Phe Leu Ile His Cys Leu Leu Asn Gly 
            660                 665                 670         


Gln Val Arg Glu Glu Tyr Lys Arg Trp Ile Xaa Gly Lys Xaa Lys Pro 
        675                 680                 685             


Ser Ser Gln Ser Gln Xaa Ser Arg Ile Leu Leu Ser Ser Met Pro Ser 
    690                 695                 700                 


Ala Ser Lys Xaa Gly 
705                 


<210> 1639
<211> 821
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<400> 1639
Met Arg Gly Phe Asn Leu Leu Leu Phe Trp Gly Cys Cys Val Met His 
1               5                   10                  15      


Ser Trp Glu Gly His Ile Arg Pro Xaa Arg Lys Pro Asn Xaa Lys Gly 
            20                  25                  30          


Asn Asn Cys Arg Asp Ser Xaa Leu Cys Pro Ala Tyr Ala Xaa Cys Xaa 
        35                  40                  45              


Asn Xaa Val Asp Ser Tyr Tyr Cys Ala Cys Lys Gln Gly Phe Leu Ser 
    50                  55                  60                  


Ser Asn Gly Gln Asn His Phe Lys Asp Pro Gly Val Arg Cys Lys Asp 
65                  70                  75                  80  


Ile Asp Glu Cys Ser Gln Ser Pro Gln Pro Cys Gly Pro Asn Ser Ser 
                85                  90                  95      


Cys Lys Asn Leu Ser Gly Arg Tyr Lys Cys Ser Cys Leu Asp Gly Phe 
            100                 105                 110         


Ser Ser Pro Xaa Gly Asn Asp Trp Val Pro Gly Lys Pro Gly Asn Phe 
        115                 120                 125             


Ser Cys Xaa Asp Ile Asn Glu Cys Leu Xaa Ser Ser Val Cys Pro Glu 
    130                 135                 140                 


His Ser Asp Cys Val Asn Ser Met Gly Ser Tyr Ser Cys Ser Cys Gln 
145                 150                 155                 160 


Val Gly Phe Ile Ser Arg Asn Ser Xaa Cys Glu Asp Val Asp Glu Cys 
                165                 170                 175     


Ala Asp Pro Arg Ala Cys Pro Glu His Ala Xaa Cys Asn Asn Xaa Val 
            180                 185                 190         


Gly Asn Tyr Ser Cys Phe Cys Asn Pro Gly Phe Glu Ser Ser Ser Gly 
        195                 200                 205             


His Leu Ser Phe Gln Gly Leu Lys Ala Ser Cys Glu Asp Ile Asp Glu 
    210                 215                 220                 


Cys Xaa Glu Met Cys Pro Ile Asn Ser Xaa Cys Xaa Asn Xaa Pro Gly 
225                 230                 235                 240 


Ser Tyr Phe Cys Xaa Cys His Pro Gly Phe Ala Pro Ser Asn Gly Gln 
                245                 250                 255     


Leu Asn Phe Xaa Asp Gln Gly Val Glu Cys Arg Asp Ile Asp Glu Cys 
            260                 265                 270         


Arg Gln Asp Pro Ser Xaa Cys Gly Pro Asn Ser Ile Cys Xaa Asn Ala 
        275                 280                 285             


Leu Gly Ser Tyr Ser Cys Gly Cys Ile Ala Gly Phe His Pro Asn Pro 
    290                 295                 300                 


Glu Gly Ser Gln Lys Asp Gly Asn Phe Ser Cys Gln Arg Val Leu Phe 
305                 310                 315                 320 


Lys Cys Lys Glu Asp Val Ile Pro Asp Asn Lys Gln Ile Gln Gln Cys 
                325                 330                 335     


Gln Glu Gly Xaa Ala Val Lys Pro Ala Tyr Val Ser Phe Cys Ala Gln 
            340                 345                 350         


Ile Asn Asn Ile Phe Ser Val Leu Asp Lys Val Cys Glu Asn Lys Xaa 
        355                 360                 365             


Xaa Val Val Ser Leu Lys Asn Xaa Xaa Glu Ser Phe Val Pro Val Leu 
    370                 375                 380                 


Lys Gln Ile Ser Xaa Trp Xaa Lys Phe Xaa Lys Glu Glu Xaa Ser Ser 
385                 390                 395                 400 


Leu Ala Xaa Val Phe Leu Glu Ser Val Glu Ser Met Xaa Leu Ala Ser 
                405                 410                 415     


Phe Trp Lys Pro Ser Ala Asn Ile Xaa Pro Ala Val Arg Xaa Glu Tyr 
            420                 425                 430         


Leu Asp Ile Glu Ser Lys Val Ile Asn Lys Glu Cys Ser Glu Glu Asn 
        435                 440                 445             


Val Xaa Leu Asp Leu Val Ala Lys Gly Asp Lys Met Lys Ile Gly Cys 
    450                 455                 460                 


Ser Xaa Ile Glu Glu Ser Glu Ser Xaa Glu Xaa Xaa Gly Val Ala Phe 
465                 470                 475                 480 


Val Ser Phe Val Gly Met Glu Ser Val Leu Asn Glu Arg Phe Phe Lys 
                485                 490                 495     


Asp His Gln Ala Pro Leu Xaa Xaa Ser Glu Ile Lys Leu Lys Met Asn 
            500                 505                 510         


Ser Arg Val Val Gly Gly Ile Met Xaa Gly Glu Lys Lys Asp Gly Phe 
        515                 520                 525             


Ser Asp Pro Ile Ile Tyr Xaa Leu Glu Asn Ile Gln Pro Lys Gln Lys 
    530                 535                 540                 


Phe Glu Arg Pro Ile Cys Val Ser Trp Ser Xaa Asp Val Lys Gly Gly 
545                 550                 555                 560 


Arg Trp Xaa Ser Phe Gly Cys Val Ile Leu Glu Ala Ser Glu Xaa Tyr 
                565                 570                 575     


Xaa Ile Cys Ser Cys Asn Gln Met Ala Asn Leu Ala Val Ile Met Ala 
            580                 585                 590         


Ser Gly Glu Leu Xaa Met Gly Cys Ala Ile Ile Ala Gly Phe Leu His 
        595                 600                 605             


Tyr Leu Phe Leu Ala Cys Phe Phe Trp Met Leu Val Glu Ala Val Ile 
    610                 615                 620                 


Leu Phe Leu Met Val Arg Asn Leu Lys Val Val Asn Tyr Phe Ser Ser 
625                 630                 635                 640 


Arg Asn Ile Lys Met Leu His Ile Cys Ala Phe Gly Tyr Gly Leu Pro 
                645                 650                 655     


Met Leu Val Val Val Ile Ser Ala Ser Val Gln Pro Gln Gly Tyr Gly 
            660                 665                 670         


Met His Asn Arg Cys Trp Leu Asn Xaa Glu Xaa Gly Phe Ile Trp Ser 
        675                 680                 685             


Phe Leu Gly Pro Val Cys Xaa Val Ile Val Ile Asn Ser Leu Leu Leu 
    690                 695                 700                 


Xaa Trp Xaa Leu Trp Ile Leu Arg Gln Arg Leu Ser Ser Val Asn Ala 
705                 710                 715                 720 


Glu Val Ser Xaa Leu Lys Asp Xaa Arg Leu Leu Xaa Phe Lys Ala Phe 
                725                 730                 735     


Ala Gln Leu Phe Ile Leu Gly Cys Ser Trp Val Leu Gly Ile Phe Gln 
            740                 745                 750         


Ile Gly Pro Val Ala Gly Val Met Ala Tyr Leu Phe Xaa Ile Ile Asn 
        755                 760                 765             


Ser Leu Gln Gly Ala Phe Ile Phe Leu Ile His Cys Leu Leu Asn Gly 
    770                 775                 780                 


Gln Val Arg Glu Glu Tyr Lys Arg Trp Ile Xaa Gly Lys Xaa Lys Pro 
785                 790                 795                 800 


Ser Ser Gln Ser Gln Xaa Ser Arg Ile Leu Leu Ser Ser Met Pro Ser 
                805                 810                 815     


Ala Ser Lys Xaa Gly 
            820     


<210> 1640
<211> 886
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<400> 1640
Met Arg Gly Phe Asn Leu Leu Leu Phe Trp Gly Cys Cys Val Met His 
1               5                   10                  15      


Ser Trp Glu Gly His Ile Arg Pro Xaa Arg Lys Pro Asn Xaa Lys Gly 
            20                  25                  30          


Asn Asn Cys Arg Asp Ser Xaa Leu Cys Pro Ala Tyr Ala Xaa Cys Xaa 
        35                  40                  45              


Asn Xaa Val Asp Ser Tyr Tyr Cys Ala Cys Lys Gln Gly Phe Leu Ser 
    50                  55                  60                  


Ser Asn Gly Gln Asn His Phe Lys Asp Pro Gly Val Arg Cys Lys Asp 
65                  70                  75                  80  


Ile Asp Glu Cys Ser Gln Ser Pro Gln Pro Cys Gly Pro Asn Ser Ser 
                85                  90                  95      


Cys Lys Asn Leu Ser Gly Arg Tyr Lys Cys Ser Cys Leu Asp Gly Phe 
            100                 105                 110         


Ser Ser Pro Xaa Gly Asn Asp Trp Val Pro Gly Lys Pro Gly Asn Phe 
        115                 120                 125             


Ser Cys Xaa Asp Ile Asn Glu Cys Leu Xaa Ser Ser Val Cys Pro Glu 
    130                 135                 140                 


His Ser Asp Cys Val Asn Ser Met Gly Ser Tyr Ser Cys Ser Cys Gln 
145                 150                 155                 160 


Val Gly Phe Ile Ser Arg Asn Ser Xaa Cys Glu Asp Val Asp Glu Cys 
                165                 170                 175     


Ala Asp Pro Arg Ala Cys Pro Glu His Ala Xaa Cys Asn Asn Xaa Val 
            180                 185                 190         


Gly Asn Tyr Ser Cys Phe Cys Asn Pro Gly Phe Glu Ser Ser Ser Gly 
        195                 200                 205             


His Leu Ser Phe Gln Gly Leu Lys Ala Ser Cys Glu Asp Ile Asp Glu 
    210                 215                 220                 


Cys Xaa Glu Met Cys Pro Ile Asn Ser Xaa Cys Xaa Asn Xaa Pro Gly 
225                 230                 235                 240 


Ser Tyr Phe Cys Xaa Cys His Pro Gly Phe Ala Pro Ser Asn Gly Gln 
                245                 250                 255     


Leu Asn Phe Xaa Asp Gln Gly Val Glu Cys Arg Asp Ile Asp Glu Cys 
            260                 265                 270         


Arg Gln Asp Pro Ser Xaa Cys Gly Pro Asn Ser Ile Cys Xaa Asn Ala 
        275                 280                 285             


Leu Gly Ser Tyr Ser Cys Gly Cys Ile Ala Gly Phe His Pro Asn Pro 
    290                 295                 300                 


Glu Gly Ser Gln Lys Asp Gly Asn Phe Ser Cys Gln Arg Val Leu Phe 
305                 310                 315                 320 


Lys Cys Lys Glu Asp Val Ile Pro Asp Asn Lys Gln Ile Gln Gln Cys 
                325                 330                 335     


Gln Glu Gly Xaa Ala Val Lys Pro Ala Tyr Val Ser Phe Cys Ala Gln 
            340                 345                 350         


Ile Asn Asn Ile Phe Ser Val Leu Asp Lys Val Cys Glu Asn Lys Xaa 
        355                 360                 365             


Xaa Val Val Ser Leu Lys Asn Xaa Xaa Glu Ser Phe Val Pro Val Leu 
    370                 375                 380                 


Lys Gln Ile Ser Xaa Trp Xaa Lys Phe Xaa Lys Glu Glu Xaa Ser Ser 
385                 390                 395                 400 


Leu Ala Xaa Val Phe Leu Glu Ser Val Glu Ser Met Xaa Leu Ala Ser 
                405                 410                 415     


Phe Trp Lys Pro Ser Ala Asn Ile Xaa Pro Ala Val Arg Xaa Glu Tyr 
            420                 425                 430         


Leu Asp Ile Glu Ser Lys Val Ile Asn Lys Glu Cys Ser Glu Glu Asn 
        435                 440                 445             


Val Xaa Leu Asp Leu Val Ala Lys Gly Asp Lys Met Lys Ile Gly Cys 
    450                 455                 460                 


Ser Xaa Ile Glu Glu Ser Glu Ser Xaa Glu Xaa Xaa Gly Val Ala Phe 
465                 470                 475                 480 


Val Ser Phe Val Gly Met Glu Ser Val Leu Asn Glu Arg Phe Phe Lys 
                485                 490                 495     


Asp His Gln Ala Pro Leu Xaa Xaa Ser Glu Ile Lys Leu Lys Met Asn 
            500                 505                 510         


Ser Arg Val Val Gly Gly Ile Met Xaa Gly Glu Lys Lys Asp Gly Phe 
        515                 520                 525             


Ser Asp Pro Ile Ile Tyr Xaa Leu Glu Asn Ile Gln Pro Lys Gln Lys 
    530                 535                 540                 


Phe Glu Arg Pro Ile Cys Val Ser Trp Ser Xaa Asp Val Lys Gly Gly 
545                 550                 555                 560 


Arg Trp Xaa Ser Phe Gly Cys Val Ile Leu Glu Ala Ser Glu Xaa Tyr 
                565                 570                 575     


Xaa Ile Cys Ser Cys Asn Gln Met Ala Asn Leu Ala Val Ile Met Ala 
            580                 585                 590         


Ser Gly Glu Leu Xaa Met Asp Phe Ser Leu Tyr Ile Ile Ser His Val 
        595                 600                 605             


Gly Ile Ile Ile Ser Leu Val Cys Leu Val Leu Ala Ile Ala Xaa Phe 
    610                 615                 620                 


Leu Leu Cys Arg Ser Ile Arg Asn His Asn Xaa Tyr Leu His Leu His 
625                 630                 635                 640 


Leu Cys Val Cys Leu Leu Leu Ala Lys Xaa Leu Phe Leu Ala Gly Ile 
                645                 650                 655     


His Lys Xaa Asp Asn Lys Met Gly Cys Ala Ile Ile Ala Gly Phe Leu 
            660                 665                 670         


His Tyr Leu Phe Leu Ala Cys Phe Phe Trp Met Leu Val Glu Ala Val 
        675                 680                 685             


Ile Leu Phe Leu Met Val Arg Asn Leu Lys Val Val Asn Tyr Phe Ser 
    690                 695                 700                 


Ser Arg Asn Ile Lys Met Leu His Ile Cys Ala Phe Gly Tyr Gly Leu 
705                 710                 715                 720 


Pro Met Leu Val Val Val Ile Ser Ala Ser Val Gln Pro Gln Gly Tyr 
                725                 730                 735     


Gly Met His Asn Arg Cys Trp Leu Asn Xaa Glu Xaa Gly Phe Ile Trp 
            740                 745                 750         


Ser Phe Leu Gly Pro Val Cys Xaa Val Ile Val Ile Asn Ser Leu Leu 
        755                 760                 765             


Leu Xaa Trp Xaa Leu Trp Ile Leu Arg Gln Arg Leu Ser Ser Val Asn 
    770                 775                 780                 


Ala Glu Val Ser Xaa Leu Lys Asp Xaa Arg Leu Leu Xaa Phe Lys Ala 
785                 790                 795                 800 


Phe Ala Gln Leu Phe Ile Leu Gly Cys Ser Trp Val Leu Gly Ile Phe 
                805                 810                 815     


Gln Ile Gly Pro Val Ala Gly Val Met Ala Tyr Leu Phe Xaa Ile Ile 
            820                 825                 830         


Asn Ser Leu Gln Gly Ala Phe Ile Phe Leu Ile His Cys Leu Leu Asn 
        835                 840                 845             


Gly Gln Val Arg Glu Glu Tyr Lys Arg Trp Ile Xaa Gly Lys Xaa Lys 
    850                 855                 860                 


Pro Ser Ser Gln Ser Gln Xaa Ser Arg Ile Leu Leu Ser Ser Met Pro 
865                 870                 875                 880 


Ser Ala Ser Lys Xaa Gly 
                885     


<210> 1641
<211> 745
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<400> 1641
Met Arg Gly Phe Asn Leu Leu Leu Phe Trp Gly Cys Cys Val Met His 
1               5                   10                  15      


Ser Trp Glu Gly His Ile Arg Pro Xaa Arg Lys Pro Asn Xaa Lys Gly 
            20                  25                  30          


Asn Asn Cys Arg Asp Ser Xaa Leu Cys Pro Ala Tyr Ala Xaa Cys Xaa 
        35                  40                  45              


Asn Xaa Val Asp Ser Tyr Tyr Cys Ala Cys Lys Gln Gly Phe Leu Ser 
    50                  55                  60                  


Ser Asn Gly Gln Asn His Phe Lys Asp Pro Gly Val Arg Cys Lys Asp 
65                  70                  75                  80  


Ile Asp Glu Cys Xaa Glu Met Cys Pro Ile Asn Ser Xaa Cys Xaa Asn 
                85                  90                  95      


Xaa Pro Gly Ser Tyr Phe Cys Xaa Cys His Pro Gly Phe Ala Pro Ser 
            100                 105                 110         


Asn Gly Gln Leu Asn Phe Xaa Asp Gln Gly Val Glu Cys Arg Asp Ile 
        115                 120                 125             


Asp Glu Cys Arg Gln Asp Pro Ser Xaa Cys Gly Pro Asn Ser Ile Cys 
    130                 135                 140                 


Xaa Asn Ala Leu Gly Ser Tyr Ser Cys Gly Cys Ile Ala Gly Phe His 
145                 150                 155                 160 


Pro Asn Pro Glu Gly Ser Gln Lys Asp Gly Asn Phe Ser Cys Gln Arg 
                165                 170                 175     


Val Leu Phe Lys Cys Lys Glu Asp Val Ile Pro Asp Asn Lys Gln Ile 
            180                 185                 190         


Gln Gln Cys Gln Glu Gly Xaa Ala Val Lys Pro Ala Tyr Val Ser Phe 
        195                 200                 205             


Cys Ala Gln Ile Asn Asn Ile Phe Ser Val Leu Asp Lys Val Cys Glu 
    210                 215                 220                 


Asn Lys Xaa Xaa Val Val Ser Leu Lys Asn Xaa Xaa Glu Ser Phe Val 
225                 230                 235                 240 


Pro Val Leu Lys Gln Ile Ser Xaa Trp Xaa Lys Phe Xaa Lys Glu Glu 
                245                 250                 255     


Xaa Ser Ser Leu Ala Xaa Val Phe Leu Glu Ser Val Glu Ser Met Xaa 
            260                 265                 270         


Leu Ala Ser Phe Trp Lys Pro Ser Ala Asn Ile Xaa Pro Ala Val Arg 
        275                 280                 285             


Xaa Glu Tyr Leu Asp Ile Glu Ser Lys Val Ile Asn Lys Glu Cys Ser 
    290                 295                 300                 


Glu Glu Asn Val Xaa Leu Asp Leu Val Ala Lys Gly Asp Lys Met Lys 
305                 310                 315                 320 


Ile Gly Cys Ser Xaa Ile Glu Glu Ser Glu Ser Xaa Glu Xaa Xaa Gly 
                325                 330                 335     


Val Ala Phe Val Ser Phe Val Gly Met Glu Ser Val Leu Asn Glu Arg 
            340                 345                 350         


Phe Phe Lys Asp His Gln Ala Pro Leu Xaa Xaa Ser Glu Ile Lys Leu 
        355                 360                 365             


Lys Met Asn Ser Arg Val Val Gly Gly Ile Met Xaa Gly Glu Lys Lys 
    370                 375                 380                 


Asp Gly Phe Ser Asp Pro Ile Ile Tyr Xaa Leu Glu Asn Ile Gln Pro 
385                 390                 395                 400 


Lys Gln Lys Phe Glu Arg Pro Ile Cys Val Ser Trp Ser Xaa Asp Val 
                405                 410                 415     


Lys Gly Gly Arg Trp Xaa Ser Phe Gly Cys Val Ile Leu Glu Ala Ser 
            420                 425                 430         


Glu Xaa Tyr Xaa Ile Cys Ser Cys Asn Gln Met Ala Asn Leu Ala Val 
        435                 440                 445             


Ile Met Ala Ser Gly Glu Leu Xaa Met Asp Phe Ser Leu Tyr Ile Ile 
    450                 455                 460                 


Ser His Val Gly Ile Ile Ile Ser Leu Val Cys Leu Val Leu Ala Ile 
465                 470                 475                 480 


Ala Xaa Phe Leu Leu Cys Arg Ser Ile Arg Asn His Asn Xaa Tyr Leu 
                485                 490                 495     


His Leu His Leu Cys Val Cys Leu Leu Leu Ala Lys Xaa Leu Phe Leu 
            500                 505                 510         


Ala Gly Ile His Lys Xaa Asp Asn Lys Met Gly Cys Ala Ile Ile Ala 
        515                 520                 525             


Gly Phe Leu His Tyr Leu Phe Leu Ala Cys Phe Phe Trp Met Leu Val 
    530                 535                 540                 


Glu Ala Val Ile Leu Phe Leu Met Val Arg Asn Leu Lys Val Val Asn 
545                 550                 555                 560 


Tyr Phe Ser Ser Arg Asn Ile Lys Met Leu His Ile Cys Ala Phe Gly 
                565                 570                 575     


Tyr Gly Leu Pro Met Leu Val Val Val Ile Ser Ala Ser Val Gln Pro 
            580                 585                 590         


Gln Gly Tyr Gly Met His Asn Arg Cys Trp Leu Asn Xaa Glu Xaa Gly 
        595                 600                 605             


Phe Ile Trp Ser Phe Leu Gly Pro Val Cys Xaa Val Ile Val Ile Asn 
    610                 615                 620                 


Ser Leu Leu Leu Xaa Trp Xaa Leu Trp Ile Leu Arg Gln Arg Leu Ser 
625                 630                 635                 640 


Ser Val Asn Ala Glu Val Ser Xaa Leu Lys Asp Xaa Arg Leu Leu Xaa 
                645                 650                 655     


Phe Lys Ala Phe Ala Gln Leu Phe Ile Leu Gly Cys Ser Trp Val Leu 
            660                 665                 670         


Gly Ile Phe Gln Ile Gly Pro Val Ala Gly Val Met Ala Tyr Leu Phe 
        675                 680                 685             


Xaa Ile Ile Asn Ser Leu Gln Gly Ala Phe Ile Phe Leu Ile His Cys 
    690                 695                 700                 


Leu Leu Asn Gly Gln Val Arg Glu Glu Tyr Lys Arg Trp Ile Xaa Gly 
705                 710                 715                 720 


Lys Xaa Lys Pro Ser Ser Gln Ser Gln Xaa Ser Arg Ile Leu Leu Ser 
                725                 730                 735     


Ser Met Pro Ser Ala Ser Lys Xaa Gly 
            740                 745 


<210> 1642
<211> 867
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<400> 1642
Met Arg Gly Phe Asn Leu Leu Leu Phe Trp Gly Cys Cys Val Met His 
1               5                   10                  15      


Ser Trp Glu Gly His Ile Arg Pro Xaa Arg Lys Pro Asn Xaa Lys Gly 
            20                  25                  30          


Asn Asn Cys Arg Asp Ser Xaa Leu Cys Pro Ala Tyr Ala Xaa Cys Xaa 
        35                  40                  45              


Asn Xaa Val Asp Ser Tyr Tyr Cys Ala Cys Lys Gln Gly Phe Leu Ser 
    50                  55                  60                  


Ser Asn Gly Gln Asn His Phe Lys Asp Pro Gly Val Arg Cys Lys Asp 
65                  70                  75                  80  


Ile Asn Glu Cys Leu Xaa Ser Ser Val Cys Pro Glu His Ser Asp Cys 
                85                  90                  95      


Val Asn Ser Met Gly Ser Tyr Ser Cys Ser Cys Gln Val Gly Phe Ile 
            100                 105                 110         


Ser Arg Asn Ser Xaa Cys Glu Asp Val Asp Glu Cys Ala Asp Pro Arg 
        115                 120                 125             


Ala Cys Pro Glu His Ala Xaa Cys Asn Asn Xaa Val Gly Asn Tyr Ser 
    130                 135                 140                 


Cys Phe Cys Asn Pro Gly Phe Glu Ser Ser Ser Gly His Leu Ser Phe 
145                 150                 155                 160 


Gln Gly Leu Lys Ala Ser Cys Glu Asp Ile Asp Glu Cys Xaa Glu Met 
                165                 170                 175     


Cys Pro Ile Asn Ser Xaa Cys Xaa Asn Xaa Pro Gly Ser Tyr Phe Cys 
            180                 185                 190         


Xaa Cys His Pro Gly Phe Ala Pro Ser Asn Gly Gln Leu Asn Phe Xaa 
        195                 200                 205             


Asp Gln Gly Val Glu Cys Arg Asp Ile Asp Glu Cys Arg Gln Asp Pro 
    210                 215                 220                 


Ser Xaa Cys Gly Pro Asn Ser Ile Cys Xaa Asn Ala Leu Gly Ser Tyr 
225                 230                 235                 240 


Ser Cys Gly Cys Ile Ala Gly Phe His Pro Asn Pro Glu Gly Ser Gln 
                245                 250                 255     


Lys Asp Gly Asn Phe Ser Cys Gln Arg Val Leu Phe Lys Cys Lys Glu 
            260                 265                 270         


Asp Val Ile Pro Asp Asn Lys Gln Ile Gln Gln Cys Gln Glu Gly Xaa 
        275                 280                 285             


Ala Val Lys Pro Ala Tyr Val Ser Phe Cys Ala Gln Ile Asn Asn Ile 
    290                 295                 300                 


Phe Ser Val Leu Asp Lys Val Cys Glu Asn Lys Xaa Xaa Val Val Ser 
305                 310                 315                 320 


Leu Lys Asn Xaa Xaa Glu Ser Phe Val Pro Val Leu Lys Gln Ile Ser 
                325                 330                 335     


Xaa Trp Xaa Lys Phe Xaa Lys Glu Glu Xaa Ser Ser Leu Ala Xaa Val 
            340                 345                 350         


Phe Leu Glu Ser Val Glu Ser Met Xaa Leu Ala Ser Phe Trp Lys Pro 
        355                 360                 365             


Ser Ala Asn Ile Xaa Pro Ala Val Arg Xaa Glu Tyr Leu Asp Ile Glu 
    370                 375                 380                 


Ser Lys Val Ile Asn Lys Glu Cys Ser Glu Glu Asn Val Xaa Leu Asp 
385                 390                 395                 400 


Leu Val Ala Lys Gly Asp Lys Met Lys Ile Gly Cys Ser Xaa Ile Glu 
                405                 410                 415     


Glu Ser Glu Ser Xaa Glu Xaa Xaa Gly Val Ala Phe Val Ser Phe Val 
            420                 425                 430         


Gly Met Glu Ser Val Leu Asn Glu Arg Phe Phe Lys Asp His Gln Ala 
        435                 440                 445             


Pro Leu Xaa Xaa Ser Glu Ile Lys Leu Lys Met Asn Ser Arg Val Val 
    450                 455                 460                 


Gly Gly Ile Met Xaa Gly Glu Lys Lys Asp Gly Phe Ser Asp Pro Ile 
465                 470                 475                 480 


Ile Tyr Xaa Leu Glu Asn Ile Gln Pro Lys Gln Lys Phe Glu Arg Pro 
                485                 490                 495     


Ile Cys Val Ser Trp Ser Xaa Asp Val Lys Gly Gly Arg Trp Xaa Ser 
            500                 505                 510         


Phe Gly Cys Val Ile Leu Glu Ala Ser Glu Xaa Tyr Xaa Ile Cys Ser 
        515                 520                 525             


Cys Asn Gln Met Ala Asn Leu Ala Val Ile Met Ala Ser Gly Glu Leu 
    530                 535                 540                 


Xaa Met Asp Phe Ser Leu Tyr Ile Ile Ser His Val Gly Ile Ile Ile 
545                 550                 555                 560 


Ser Leu Val Cys Leu Val Leu Ala Ile Ala Xaa Phe Leu Leu Cys Arg 
                565                 570                 575     


Ser Ile Arg Asn His Asn Xaa Tyr Leu His Leu His Leu Cys Val Cys 
            580                 585                 590         


Leu Leu Leu Ala Lys Xaa Leu Phe Leu Ala Gly Ile His Lys Xaa Asp 
        595                 600                 605             


Asn Lys Met Gly Cys Ala Ile Ile Ala Gly Phe Leu His Tyr Leu Phe 
    610                 615                 620                 


Leu Ala Cys Phe Phe Trp Met Leu Val Glu Ala Val Ile Leu Phe Leu 
625                 630                 635                 640 


Met Val Arg Asn Leu Lys Val Val Asn Tyr Phe Ser Ser Arg Asn Ile 
                645                 650                 655     


Lys Met Leu His Ile Cys Ala Phe Gly Tyr Gly Leu Pro Met Leu Val 
            660                 665                 670         


Val Val Ile Ser Ala Ser Val Gln Pro Gln Gly Tyr Gly Met His Asn 
        675                 680                 685             


Arg Cys Trp Leu Asn Xaa Glu Xaa Gly Phe Ile Trp Ser Phe Leu Gly 
    690                 695                 700                 


Pro Val Cys Xaa Val Ile Val Val Ser Lys Tyr Tyr Asn Ser Leu Ala 
705                 710                 715                 720 


Lys Cys Val Leu Lys Glu Glu Gln Gly Asp Leu Arg Asp Leu Glu Phe 
                725                 730                 735     


Pro Gly Xaa Cys Ala Ala Glu Arg Ile Asn Ser Leu Leu Leu Xaa Trp 
            740                 745                 750         


Xaa Leu Trp Ile Leu Arg Gln Arg Leu Ser Ser Val Asn Ala Glu Val 
        755                 760                 765             


Ser Xaa Leu Lys Asp Xaa Arg Leu Leu Xaa Phe Lys Ala Phe Ala Gln 
    770                 775                 780                 


Leu Phe Ile Leu Gly Cys Ser Trp Val Leu Gly Ile Phe Gln Ile Gly 
785                 790                 795                 800 


Pro Val Ala Gly Val Met Ala Tyr Leu Phe Xaa Ile Ile Asn Ser Leu 
                805                 810                 815     


Gln Gly Ala Phe Ile Phe Leu Ile His Cys Leu Leu Asn Gly Gln Val 
            820                 825                 830         


Arg Glu Glu Tyr Lys Arg Trp Ile Xaa Gly Lys Xaa Lys Pro Ser Ser 
        835                 840                 845             


Gln Ser Gln Xaa Ser Arg Ile Leu Leu Ser Ser Met Pro Ser Ala Ser 
    850                 855                 860                 


Lys Xaa Gly 
865         


<210> 1643
<211> 681
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<400> 1643
Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Xaa Leu Pro Gly Ala Glu Xaa Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Xaa Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Xaa Xaa Pro Met Glu Xaa 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Xaa Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Xaa Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Xaa Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Xaa Cys Gln Asp Met Xaa Phe Ser Xaa Trp Xaa Pro Pro 
        115                 120                 125             


Pro Gly Val His Ser Gln Xaa Leu Ser Arg Phe Phe Asp Lys Val Gln 
    130                 135                 140                 


Asp Leu Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Xaa Ile Gln 
145                 150                 155                 160 


Ser Ile Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu 
                165                 170                 175     


Glu Xaa Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu 
            180                 185                 190         


Asp Gly Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn 
        195                 200                 205             


Gly Leu Leu Asn Phe Ser Tyr Pro Ala Gly Xaa Glu Leu Ser Leu Glu 
    210                 215                 220                 


Val Gln Lys Gln Val Asp Arg Ser Val Xaa Leu Arg Gln Asn Gln Ala 
225                 230                 235                 240 


Val Met Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly 
                245                 250                 255     


Pro Ser Val Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu Leu 
            260                 265                 270         


Ala Glu Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu His 
        275                 280                 285             


Glu Xaa His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu Ser 
    290                 295                 300                 


Asp Val Ile Ser Ala Phe Leu Ser Asn Asn Asp Xaa Gln Asn Leu Ser 
305                 310                 315                 320 


Ser Pro Val Xaa Phe Xaa Phe Ser His Arg Ser Val Ile Pro Arg Gln 
                325                 330                 335     


Lys Val Leu Cys Val Phe Trp Glu His Gly Gln Asn Gly Cys Gly His 
            340                 345                 350         


Trp Ala Xaa Xaa Gly Cys Ser Xaa Ile Gly Xaa Arg Asp Xaa Ser Xaa 
        355                 360                 365             


Ile Cys Arg Cys Xaa His Leu Ser Ser Phe Ala Val Leu Met Ala His 
    370                 375                 380                 


Tyr Asp Val Gln Glu Glu Asp Pro Val Leu Xaa Val Ile Xaa Tyr Met 
385                 390                 395                 400 


Gly Leu Ser Val Ser Leu Leu Cys Leu Leu Leu Ala Ala Leu Xaa Phe 
                405                 410                 415     


Leu Leu Cys Lys Ala Ile Gln Asn Xaa Ser Xaa Ser Leu His Leu Gln 
            420                 425                 430         


Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu Phe Leu Val Ala Ile 
        435                 440                 445             


Asp Gln Xaa Gly His Lys Val Leu Cys Ser Ile Ile Ala Gly Xaa Leu 
    450                 455                 460                 


His Tyr Leu Tyr Leu Ala Xaa Leu Xaa Trp Met Leu Leu Glu Ala Leu 
465                 470                 475                 480 


Tyr Leu Phe Leu Xaa Ala Arg Asn Leu Xaa Val Val Asn Tyr Ser Ser 
                485                 490                 495     


Ile Asn Arg Phe Met Lys Lys Leu Met Phe Pro Val Gly Tyr Gly Val 
            500                 505                 510         


Pro Ala Val Xaa Val Ala Ile Ser Ala Ala Ser Arg Pro His Leu Tyr 
        515                 520                 525             


Gly Xaa Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys Gly Phe Ile Trp 
    530                 535                 540                 


Gly Phe Leu Gly Pro Val Cys Ala Ile Phe Ser Val Asn Leu Val Leu 
545                 550                 555                 560 


Phe Leu Val Xaa Leu Trp Ile Leu Lys Asn Arg Leu Ser Ser Leu Asn 
                565                 570                 575     


Ser Glu Val Ser Xaa Leu Arg Asn Xaa Arg Met Leu Ala Phe Lys Ala 
            580                 585                 590         


Xaa Ala Gln Leu Phe Ile Leu Gly Cys Xaa Trp Cys Leu Gly Ile Leu 
        595                 600                 605             


Gln Val Gly Pro Ala Ala Arg Val Met Ala Tyr Leu Phe Xaa Ile Ile 
    610                 615                 620                 


Asn Ser Leu Gln Gly Val Phe Ile Phe Leu Val Tyr Cys Leu Leu Ser 
625                 630                 635                 640 


Gln Gln Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys Gly Ile Arg Lys 
                645                 650                 655     


Leu Lys Xaa Glu Ser Glu Met His Xaa Leu Ser Ser Ser Ala Lys Ala 
            660                 665                 670         


Asp Xaa Ser Lys Pro Ser Xaa Val Asn 
        675                 680     


<210> 1644
<211> 379
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<400> 1644
Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Xaa Leu Pro Gly Ala Glu Xaa Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Xaa Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Xaa Xaa Pro Met Glu Xaa 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Xaa Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Xaa Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Xaa Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Xaa Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Xaa Cys Val Asn Xaa Leu Gly Ser Tyr Xaa 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Xaa Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser 
                165                 170                 175     


Ser Xaa Val Cys Phe Asn Xaa Val Gly Ser Tyr Ser Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Xaa 
        195                 200                 205             


Val Cys Glu Asp Met Xaa Phe Ser Xaa Trp Xaa Pro Pro Pro Gly Val 
    210                 215                 220                 


His Ser Gln Xaa Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly 
225                 230                 235                 240 


Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Xaa Ile Gln Ser Ile Leu 
                245                 250                 255     


Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Xaa Leu 
            260                 265                 270         


Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly Leu 
        275                 280                 285             


Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu Leu 
    290                 295                 300                 


Asn Phe Ser Tyr Pro Ala Gly Xaa Glu Leu Ser Leu Glu Val Gln Lys 
305                 310                 315                 320 


Gln Val Asp Arg Ser Val Xaa Leu Arg Gln Asn Gln Ala Val Met Gln 
                325                 330                 335     


Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Gly Gly Ser 
            340                 345                 350         


Arg Ala Asp Cys His His Leu His Gly Ala Glu Arg Leu Ser Ala Val 
        355                 360                 365             


Pro Pro Pro Gly Gly Pro His Phe Ser Pro Val 
    370                 375                 


<210> 1645
<211> 774
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<400> 1645
Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Xaa Leu Pro Gly Ala Glu Xaa Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Xaa Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Xaa Xaa Pro Met Glu Xaa 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Xaa Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Xaa Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Xaa Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Xaa Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Xaa Cys Val Asn Xaa Leu Gly Ser Tyr Xaa 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Xaa Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser 
                165                 170                 175     


Ser Xaa Val Cys Phe Asn Xaa Val Gly Ser Tyr Ser Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Xaa 
        195                 200                 205             


Val Cys Glu Asp Met Xaa Phe Ser Xaa Trp Xaa Pro Pro Pro Gly Val 
    210                 215                 220                 


His Ser Gln Xaa Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly 
225                 230                 235                 240 


Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Xaa Ile Gln Ser Ile Leu 
                245                 250                 255     


Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Xaa Leu 
            260                 265                 270         


Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly Leu 
        275                 280                 285             


Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu Leu 
    290                 295                 300                 


Asn Phe Ser Tyr Pro Ala Gly Xaa Glu Leu Ser Leu Glu Val Gln Lys 
305                 310                 315                 320 


Gln Val Asp Arg Ser Val Xaa Leu Arg Gln Asn Gln Ala Val Met Gln 
                325                 330                 335     


Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Pro Ser Val 
            340                 345                 350         


Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu Leu Ala Glu Ala 
        355                 360                 365             


Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu His Glu Xaa His 
    370                 375                 380                 


Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu Ser Asp Val Ile 
385                 390                 395                 400 


Ser Ala Phe Leu Ser Asn Asn Asp Xaa Gln Asn Leu Ser Ser Pro Val 
                405                 410                 415     


Xaa Phe Xaa Phe Ser His Arg Ser Val Ile Pro Arg Gln Lys Val Leu 
            420                 425                 430         


Cys Val Phe Trp Glu His Gly Gln Asn Gly Cys Gly His Trp Ala Xaa 
        435                 440                 445             


Xaa Gly Cys Ser Xaa Ile Gly Xaa Arg Asp Xaa Ser Xaa Ile Cys Arg 
    450                 455                 460                 


Cys Xaa His Leu Ser Ser Phe Ala Val Leu Met Ala His Tyr Asp Val 
465                 470                 475                 480 


Gln Glu Glu Asp Pro Val Leu Xaa Val Ile Xaa Tyr Met Gly Leu Ser 
                485                 490                 495     


Val Ser Leu Leu Cys Leu Leu Leu Ala Ala Leu Xaa Phe Leu Leu Cys 
            500                 505                 510         


Lys Ala Ile Gln Asn Xaa Ser Xaa Ser Leu His Leu Gln Leu Ser Leu 
        515                 520                 525             


Cys Leu Phe Leu Ala His Leu Leu Phe Leu Val Ala Ile Asp Gln Xaa 
    530                 535                 540                 


Gly His Lys Val Leu Cys Ser Ile Ile Ala Gly Xaa Leu His Tyr Leu 
545                 550                 555                 560 


Tyr Leu Ala Xaa Leu Xaa Trp Met Leu Leu Glu Ala Leu Tyr Leu Phe 
                565                 570                 575     


Leu Xaa Ala Arg Asn Leu Xaa Val Val Asn Tyr Ser Ser Ile Asn Arg 
            580                 585                 590         


Phe Met Lys Lys Leu Met Phe Pro Val Gly Tyr Gly Val Pro Ala Val 
        595                 600                 605             


Xaa Val Ala Ile Ser Ala Ala Ser Arg Pro His Leu Tyr Gly Xaa Pro 
    610                 615                 620                 


Ser Arg Cys Trp Leu Gln Pro Glu Lys Gly Phe Ile Trp Gly Phe Leu 
625                 630                 635                 640 


Gly Pro Val Cys Ala Ile Phe Ser Val Asn Leu Val Leu Phe Leu Val 
                645                 650                 655     


Xaa Leu Trp Ile Leu Lys Asn Arg Leu Ser Ser Leu Asn Ser Glu Val 
            660                 665                 670         


Ser Xaa Leu Arg Asn Xaa Arg Met Leu Ala Phe Lys Ala Xaa Ala Gln 
        675                 680                 685             


Leu Phe Ile Leu Gly Cys Xaa Trp Cys Leu Gly Ile Leu Gln Val Gly 
    690                 695                 700                 


Pro Ala Ala Arg Val Met Ala Tyr Leu Phe Xaa Ile Ile Asn Ser Leu 
705                 710                 715                 720 


Gln Gly Val Phe Ile Phe Leu Val Tyr Cys Leu Leu Ser Gln Gln Val 
                725                 730                 735     


Arg Glu Gln Tyr Gly Lys Trp Ser Lys Gly Ile Arg Lys Leu Lys Xaa 
            740                 745                 750         


Glu Ser Glu Met His Xaa Leu Ser Ser Ser Ala Lys Ala Asp Xaa Ser 
        755                 760                 765             


Lys Pro Ser Xaa Val Asn 
    770                 


<210> 1646
<211> 765
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<400> 1646
Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Xaa Leu Pro Gly Ala Glu Xaa Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Xaa Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Xaa Xaa Pro Met Glu Xaa 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Xaa Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Xaa Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Xaa Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Xaa Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Xaa Cys Val Asn Xaa Leu Gly Ser Tyr Xaa 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Xaa Asp Val Asn Glu Cys Xaa Ser Gly Gln Asn Pro Cys His Ser 
                165                 170                 175     


Ser Xaa His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Xaa 
        195                 200                 205             


Val Cys Glu Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
    210                 215                 220                 


Ser Ser Xaa Val Cys Phe Asn Xaa Val Gly Ser Tyr Ser Cys Arg Cys 
225                 230                 235                 240 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
                245                 250                 255     


Xaa Val Cys Glu Asp Met Xaa Phe Ser Xaa Trp Xaa Pro Pro Pro Gly 
            260                 265                 270         


Val His Ser Gln Xaa Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
        275                 280                 285             


Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Xaa Ile Gln Ser Ile 
    290                 295                 300                 


Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Xaa 
305                 310                 315                 320 


Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly 
                325                 330                 335     


Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu 
            340                 345                 350         


Leu Asn Phe Ser Tyr Pro Ala Gly Xaa Glu Leu Ser Leu Glu Val Gln 
        355                 360                 365             


Lys Gln Val Asp Arg Ser Val Xaa Leu Arg Gln Asn Gln Ala Val Met 
    370                 375                 380                 


Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Pro Ser 
385                 390                 395                 400 


Val Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu Leu Ala Glu 
                405                 410                 415     


Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu His Glu Xaa 
            420                 425                 430         


His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu Ser Asp Val 
        435                 440                 445             


Ile Ser Ala Phe Leu Ser Asn Asn Asp Xaa Gln Asn Leu Ser Ser Pro 
    450                 455                 460                 


Val Xaa Phe Xaa Phe Ser His Arg Glu Glu Asp Pro Val Leu Xaa Val 
465                 470                 475                 480 


Ile Xaa Tyr Met Gly Leu Ser Val Ser Leu Leu Cys Leu Leu Leu Ala 
                485                 490                 495     


Ala Leu Xaa Phe Leu Leu Cys Lys Ala Ile Gln Asn Xaa Ser Xaa Ser 
            500                 505                 510         


Leu His Leu Gln Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu Phe 
        515                 520                 525             


Leu Val Ala Ile Asp Gln Xaa Gly His Lys Val Leu Cys Ser Ile Ile 
    530                 535                 540                 


Ala Gly Xaa Leu His Tyr Leu Tyr Leu Ala Xaa Leu Xaa Trp Met Leu 
545                 550                 555                 560 


Leu Glu Ala Leu Tyr Leu Phe Leu Xaa Ala Arg Asn Leu Xaa Val Val 
                565                 570                 575     


Asn Tyr Ser Ser Ile Asn Arg Phe Met Lys Lys Leu Met Phe Pro Val 
            580                 585                 590         


Gly Tyr Gly Val Pro Ala Val Xaa Val Ala Ile Ser Ala Ala Ser Arg 
        595                 600                 605             


Pro His Leu Tyr Gly Xaa Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys 
    610                 615                 620                 


Gly Phe Ile Trp Gly Phe Leu Gly Pro Val Cys Ala Ile Phe Ser Val 
625                 630                 635                 640 


Asn Leu Val Leu Phe Leu Val Xaa Leu Trp Ile Leu Lys Asn Arg Leu 
                645                 650                 655     


Ser Ser Leu Asn Ser Glu Val Ser Xaa Leu Arg Asn Xaa Arg Met Leu 
            660                 665                 670         


Ala Phe Lys Ala Xaa Ala Gln Leu Phe Ile Leu Gly Cys Xaa Trp Cys 
        675                 680                 685             


Leu Gly Ile Leu Gln Val Gly Pro Ala Ala Arg Val Met Ala Tyr Leu 
    690                 695                 700                 


Phe Xaa Ile Ile Asn Ser Leu Gln Gly Val Phe Ile Phe Leu Val Tyr 
705                 710                 715                 720 


Cys Leu Leu Ser Gln Gln Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys 
                725                 730                 735     


Gly Ile Arg Lys Leu Lys Xaa Glu Ser Glu Met His Xaa Leu Ser Ser 
            740                 745                 750         


Ser Ala Lys Ala Asp Xaa Ser Lys Pro Ser Xaa Val Asn 
        755                 760                 765 


<210> 1647
<211> 812
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<400> 1647
Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Xaa Leu Pro Gly Ala Glu Xaa Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Xaa Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Xaa Xaa Pro Met Glu Xaa 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Xaa Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Xaa Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Xaa Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Xaa Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Xaa Cys Val Asn Xaa Leu Gly Ser Tyr Xaa 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Xaa Asp Val Asn Glu Cys Xaa Ser Gly Gln Asn Pro Cys His Ser 
                165                 170                 175     


Ser Xaa His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Xaa 
        195                 200                 205             


Val Cys Glu Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
    210                 215                 220                 


Ser Ser Xaa Val Cys Phe Asn Xaa Val Gly Ser Tyr Ser Cys Arg Cys 
225                 230                 235                 240 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
                245                 250                 255     


Xaa Val Cys Glu Asp Met Xaa Phe Ser Xaa Trp Xaa Pro Pro Pro Gly 
            260                 265                 270         


Val His Ser Gln Xaa Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
        275                 280                 285             


Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Xaa Ile Gln Ser Ile 
    290                 295                 300                 


Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Xaa 
305                 310                 315                 320 


Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly 
                325                 330                 335     


Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu 
            340                 345                 350         


Leu Asn Phe Ser Tyr Pro Ala Gly Xaa Glu Leu Ser Leu Glu Val Gln 
        355                 360                 365             


Lys Gln Val Asp Arg Ser Val Xaa Leu Arg Gln Asn Gln Ala Val Met 
    370                 375                 380                 


Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Met Gly 
385                 390                 395                 400 


Lys Leu Leu Ala Glu Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met 
                405                 410                 415     


Leu Leu His Glu Xaa His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile 
            420                 425                 430         


Leu Leu Ser Asp Val Ile Ser Ala Phe Leu Ser Asn Asn Asp Xaa Gln 
        435                 440                 445             


Asn Leu Ser Ser Pro Val Xaa Phe Xaa Phe Ser His Arg Ser Val Ile 
    450                 455                 460                 


Pro Arg Gln Lys Val Leu Cys Val Phe Trp Glu His Gly Gln Asn Gly 
465                 470                 475                 480 


Cys Gly His Trp Ala Xaa Xaa Gly Cys Ser Xaa Ile Gly Xaa Arg Asp 
                485                 490                 495     


Xaa Ser Xaa Ile Cys Arg Cys Xaa His Leu Ser Ser Phe Ala Val Leu 
            500                 505                 510         


Met Ala His Tyr Asp Val Gln Glu Glu Asp Pro Val Leu Xaa Val Ile 
        515                 520                 525             


Xaa Tyr Met Gly Leu Ser Val Ser Leu Leu Cys Leu Leu Leu Ala Ala 
    530                 535                 540                 


Leu Xaa Phe Leu Leu Cys Lys Ala Ile Gln Asn Xaa Ser Xaa Ser Leu 
545                 550                 555                 560 


His Leu Gln Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu Phe Leu 
                565                 570                 575     


Val Ala Ile Asp Gln Xaa Gly His Lys Val Leu Cys Ser Ile Ile Ala 
            580                 585                 590         


Gly Xaa Leu His Tyr Leu Tyr Leu Ala Xaa Leu Xaa Trp Met Leu Leu 
        595                 600                 605             


Glu Ala Leu Tyr Leu Phe Leu Xaa Ala Arg Asn Leu Xaa Val Val Asn 
    610                 615                 620                 


Tyr Ser Ser Ile Asn Arg Phe Met Lys Lys Leu Met Phe Pro Val Gly 
625                 630                 635                 640 


Tyr Gly Val Pro Ala Val Xaa Val Ala Ile Ser Ala Ala Ser Arg Pro 
                645                 650                 655     


His Leu Tyr Gly Xaa Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys Gly 
            660                 665                 670         


Phe Ile Trp Gly Phe Leu Gly Pro Val Cys Ala Ile Phe Ser Val Asn 
        675                 680                 685             


Leu Val Leu Phe Leu Val Xaa Leu Trp Ile Leu Lys Asn Arg Leu Ser 
    690                 695                 700                 


Ser Leu Asn Ser Glu Val Ser Xaa Leu Arg Asn Xaa Arg Met Leu Ala 
705                 710                 715                 720 


Phe Lys Ala Xaa Ala Gln Leu Phe Ile Leu Gly Cys Xaa Trp Cys Leu 
                725                 730                 735     


Gly Ile Leu Gln Val Gly Pro Ala Ala Arg Val Met Ala Tyr Leu Phe 
            740                 745                 750         


Xaa Ile Ile Asn Ser Leu Gln Gly Val Phe Ile Phe Leu Val Tyr Cys 
        755                 760                 765             


Leu Leu Ser Gln Gln Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys Gly 
    770                 775                 780                 


Ile Arg Lys Leu Lys Xaa Glu Ser Glu Met His Xaa Leu Ser Ser Ser 
785                 790                 795                 800 


Ala Lys Ala Asp Xaa Ser Lys Pro Ser Xaa Val Asn 
                805                 810         


<210> 1648
<211> 823
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<400> 1648
Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Xaa Leu Pro Gly Ala Glu Xaa Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Xaa Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Xaa Xaa Pro Met Glu Xaa 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Xaa Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Xaa Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Xaa Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Xaa Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Xaa Cys Val Asn Xaa Leu Gly Ser Tyr Xaa 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Xaa Asp Val Asn Glu Cys Xaa Ser Gly Gln Asn Pro Cys His Ser 
                165                 170                 175     


Ser Xaa His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Xaa 
        195                 200                 205             


Val Cys Glu Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
    210                 215                 220                 


Ser Ser Xaa Val Cys Phe Asn Xaa Val Gly Ser Tyr Ser Cys Arg Cys 
225                 230                 235                 240 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
                245                 250                 255     


Xaa Val Cys Glu Asp Met Xaa Phe Ser Xaa Trp Xaa Pro Pro Pro Gly 
            260                 265                 270         


Val His Ser Gln Xaa Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
        275                 280                 285             


Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Xaa Ile Gln Ser Ile 
    290                 295                 300                 


Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Xaa 
305                 310                 315                 320 


Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly 
                325                 330                 335     


Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu 
            340                 345                 350         


Leu Asn Phe Ser Tyr Pro Ala Gly Xaa Glu Leu Ser Leu Glu Val Gln 
        355                 360                 365             


Lys Gln Val Asp Arg Ser Val Xaa Leu Arg Gln Asn Gln Ala Val Met 
    370                 375                 380                 


Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Pro Ser 
385                 390                 395                 400 


Val Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu Leu Ala Glu 
                405                 410                 415     


Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu His Glu Xaa 
            420                 425                 430         


His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu Ser Asp Val 
        435                 440                 445             


Ile Ser Ala Phe Leu Ser Asn Asn Asp Xaa Gln Asn Leu Ser Ser Pro 
    450                 455                 460                 


Val Xaa Phe Xaa Phe Ser His Arg Ser Val Ile Pro Arg Gln Lys Val 
465                 470                 475                 480 


Leu Cys Val Phe Trp Glu His Gly Gln Asn Gly Cys Gly His Trp Ala 
                485                 490                 495     


Xaa Xaa Gly Cys Ser Xaa Ile Gly Xaa Arg Asp Xaa Ser Xaa Ile Cys 
            500                 505                 510         


Arg Cys Xaa His Leu Ser Ser Phe Ala Val Leu Met Ala His Tyr Asp 
        515                 520                 525             


Val Gln Glu Glu Asp Pro Val Leu Xaa Val Ile Xaa Tyr Met Gly Leu 
    530                 535                 540                 


Ser Val Ser Leu Leu Cys Leu Leu Leu Ala Ala Leu Xaa Phe Leu Leu 
545                 550                 555                 560 


Cys Lys Ala Ile Gln Asn Xaa Ser Xaa Ser Leu His Leu Gln Leu Ser 
                565                 570                 575     


Leu Cys Leu Phe Leu Ala His Leu Leu Phe Leu Val Ala Ile Asp Gln 
            580                 585                 590         


Xaa Gly His Lys Val Leu Cys Ser Ile Ile Ala Gly Xaa Leu His Tyr 
        595                 600                 605             


Leu Tyr Leu Ala Xaa Leu Xaa Trp Met Leu Leu Glu Ala Leu Tyr Leu 
    610                 615                 620                 


Phe Leu Xaa Ala Arg Asn Leu Xaa Val Val Asn Tyr Ser Ser Ile Asn 
625                 630                 635                 640 


Arg Phe Met Lys Lys Leu Met Phe Pro Val Gly Tyr Gly Val Pro Ala 
                645                 650                 655     


Val Xaa Val Ala Ile Ser Ala Ala Ser Arg Pro His Leu Tyr Gly Xaa 
            660                 665                 670         


Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys Gly Phe Ile Trp Gly Phe 
        675                 680                 685             


Leu Gly Pro Val Cys Ala Ile Phe Ser Val Asn Leu Val Leu Phe Leu 
    690                 695                 700                 


Val Xaa Leu Trp Ile Leu Lys Asn Arg Leu Ser Ser Leu Asn Ser Glu 
705                 710                 715                 720 


Val Ser Xaa Leu Arg Asn Xaa Arg Met Leu Ala Phe Lys Ala Xaa Ala 
                725                 730                 735     


Gln Leu Phe Ile Leu Gly Cys Xaa Trp Cys Leu Gly Ile Leu Gln Val 
            740                 745                 750         


Gly Pro Ala Ala Arg Val Met Ala Tyr Leu Phe Xaa Ile Ile Asn Ser 
        755                 760                 765             


Leu Gln Gly Val Phe Ile Phe Leu Val Tyr Cys Leu Leu Ser Gln Gln 
    770                 775                 780                 


Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys Gly Ile Arg Lys Leu Lys 
785                 790                 795                 800 


Xaa Glu Ser Glu Met His Xaa Leu Ser Ser Ser Ala Lys Ala Asp Xaa 
                805                 810                 815     


Ser Lys Pro Ser Xaa Val Asn 
            820             


<210> 1649
<211> 831
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<400> 1649
Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Xaa Leu Pro Gly Ala Glu Xaa Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Xaa Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Xaa Xaa Pro Met Glu Xaa 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Xaa Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Xaa Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Xaa Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Xaa Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Xaa Cys Val Asn Xaa Leu Gly Ser Tyr Xaa 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Xaa Asp Val Asn Glu Cys Xaa Ser Gly Gln Asn Pro Cys His Ser 
                165                 170                 175     


Ser Xaa His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Xaa 
        195                 200                 205             


Val Cys Glu Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
    210                 215                 220                 


Ser Ser Xaa Val Cys Phe Asn Xaa Val Gly Ser Tyr Ser Cys Arg Cys 
225                 230                 235                 240 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
                245                 250                 255     


Xaa Val Cys Glu Asp Met Xaa Phe Ser Xaa Trp Xaa Pro Pro Pro Gly 
            260                 265                 270         


Val His Ser Gln Xaa Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
        275                 280                 285             


Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Xaa Ile Gln Ser Ile 
    290                 295                 300                 


Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Xaa 
305                 310                 315                 320 


Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly 
                325                 330                 335     


Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu 
            340                 345                 350         


Leu Asn Phe Ser Tyr Pro Ala Gly Xaa Glu Leu Ser Leu Glu Val Gln 
        355                 360                 365             


Lys Gln Val Asp Arg Ser Val Xaa Leu Arg Gln Asn Gln Ala Val Met 
    370                 375                 380                 


Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Met Gly 
385                 390                 395                 400 


Lys Leu Leu Ala Glu Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met 
                405                 410                 415     


Leu Leu His Glu Xaa His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile 
            420                 425                 430         


Leu Leu Ser Asp Val Ile Ser Ala Phe Leu Ser Asn Asn Asp Xaa Gln 
        435                 440                 445             


Asn Leu Ser Ser Pro Val Xaa Phe Xaa Phe Ser His Arg Ser Val Ile 
    450                 455                 460                 


Pro Arg Gln Lys Val Leu Cys Val Phe Trp Glu His Gly Gln Asn Gly 
465                 470                 475                 480 


Cys Gly His Trp Ala Xaa Xaa Gly Cys Ser Xaa Ile Gly Xaa Arg Asp 
                485                 490                 495     


Xaa Ser Xaa Ile Cys Arg Cys Xaa His Leu Ser Ser Phe Ala Val Leu 
            500                 505                 510         


Met Ala His Tyr Asp Val Gln Glu Glu Asp Pro Val Leu Xaa Val Ile 
        515                 520                 525             


Xaa Tyr Met Gly Leu Ser Val Ser Leu Leu Cys Leu Leu Leu Ala Ala 
    530                 535                 540                 


Leu Xaa Phe Leu Leu Cys Lys Ala Ile Gln Asn Xaa Ser Xaa Ser Leu 
545                 550                 555                 560 


His Leu Gln Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu Phe Leu 
                565                 570                 575     


Val Ala Ile Asp Gln Xaa Gly His Lys Val Leu Cys Ser Ile Ile Ala 
            580                 585                 590         


Gly Xaa Leu His Tyr Leu Tyr Leu Ala Xaa Leu Xaa Trp Met Leu Leu 
        595                 600                 605             


Glu Ala Leu Tyr Leu Phe Leu Xaa Ala Arg Asn Leu Xaa Val Val Asn 
    610                 615                 620                 


Tyr Ser Ser Ile Asn Arg Phe Met Lys Lys Leu Met Phe Pro Val Gly 
625                 630                 635                 640 


Tyr Gly Val Pro Ala Val Xaa Val Ala Ile Ser Ala Ala Ser Arg Pro 
                645                 650                 655     


His Leu Tyr Gly Xaa Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys Gly 
            660                 665                 670         


Phe Ile Trp Gly Phe Leu Gly Pro Val Cys Ala Ile Phe Ser Val Asn 
        675                 680                 685             


Leu Val Leu Phe Leu Val Xaa Leu Trp Ile Leu Lys Asn Arg Leu Ser 
    690                 695                 700                 


Ser Leu Asn Ser Glu Val Ser Xaa Leu Arg Asn Xaa Arg Met Leu Ala 
705                 710                 715                 720 


Phe Lys Ala Xaa Ala Gln Leu Phe Ile Leu Gly Cys Xaa Trp Cys Leu 
                725                 730                 735     


Gly Ile Leu Gln Val Gly Pro Ala Ala Arg Val Met Ala Tyr Leu Phe 
            740                 745                 750         


Xaa Ile Ile Asn Ser Leu Gln Gly Val Phe Ile Phe Leu Val Tyr Cys 
        755                 760                 765             


Leu Leu Ser Gln Gln Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys Gly 
    770                 775                 780                 


Ile Arg Lys Leu Lys Xaa Glu Ser Glu Met His Xaa Leu Ser Ser Ser 
785                 790                 795                 800 


Ala Lys Ala Asp Xaa Ser Lys Pro Ser Xaa Pro Gly Xaa Val Val Gln 
                805                 810                 815     


Ala Cys Asn Ala Ser Xaa Leu Gly Gly Gln Ser Arg Lys Ile Xaa 
            820                 825                 830     


<210> 1650
<211> 730
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<400> 1650
Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Xaa Leu Pro Gly Ala Glu Xaa Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Xaa Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Xaa Xaa Pro Met Glu Xaa 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Xaa Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Xaa Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Xaa Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Xaa Cys Gln Asp Val Asp Glu Cys Ser Ser Gly Gln His 
        115                 120                 125             


Gln Cys Asp Ser Ser Xaa Val Cys Phe Asn Xaa Val Gly Ser Tyr Ser 
    130                 135                 140                 


Cys Arg Cys Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn 
145                 150                 155                 160 


Gln Lys Asp Xaa Val Cys Glu Asp Met Xaa Phe Ser Xaa Trp Xaa Pro 
                165                 170                 175     


Pro Pro Gly Val His Ser Gln Xaa Leu Ser Arg Phe Phe Asp Lys Val 
            180                 185                 190         


Gln Asp Leu Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Xaa Ile 
        195                 200                 205             


Gln Ser Ile Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp 
    210                 215                 220                 


Leu Glu Xaa Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu 
225                 230                 235                 240 


Leu Asp Gly Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser 
                245                 250                 255     


Asn Gly Leu Leu Asn Phe Ser Tyr Pro Ala Gly Xaa Glu Leu Ser Leu 
            260                 265                 270         


Glu Val Gln Lys Gln Val Asp Arg Ser Val Xaa Leu Arg Gln Asn Gln 
        275                 280                 285             


Ala Val Met Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro 
    290                 295                 300                 


Gly Pro Ser Val Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu 
305                 310                 315                 320 


Leu Ala Glu Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu 
                325                 330                 335     


His Glu Xaa His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu 
            340                 345                 350         


Ser Asp Val Ile Ser Ala Phe Leu Ser Asn Asn Asp Xaa Gln Asn Leu 
        355                 360                 365             


Ser Ser Pro Val Xaa Phe Xaa Phe Ser His Arg Ser Val Ile Pro Arg 
    370                 375                 380                 


Gln Lys Val Leu Cys Val Phe Trp Glu His Gly Gln Asn Gly Cys Gly 
385                 390                 395                 400 


His Trp Ala Xaa Xaa Gly Cys Ser Xaa Ile Gly Xaa Arg Asp Xaa Ser 
                405                 410                 415     


Xaa Ile Cys Arg Cys Xaa His Leu Ser Ser Phe Ala Val Leu Met Ala 
            420                 425                 430         


His Tyr Asp Val Gln Glu Glu Asp Pro Val Leu Xaa Val Ile Xaa Tyr 
        435                 440                 445             


Met Gly Leu Ser Val Ser Leu Leu Cys Leu Leu Leu Ala Ala Leu Xaa 
    450                 455                 460                 


Phe Leu Leu Cys Lys Ala Ile Gln Asn Xaa Ser Xaa Ser Leu His Leu 
465                 470                 475                 480 


Gln Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu Phe Leu Val Ala 
                485                 490                 495     


Ile Asp Gln Xaa Gly His Lys Val Leu Cys Ser Ile Ile Ala Gly Xaa 
            500                 505                 510         


Leu His Tyr Leu Tyr Leu Ala Xaa Leu Xaa Trp Met Leu Leu Glu Ala 
        515                 520                 525             


Leu Tyr Leu Phe Leu Xaa Ala Arg Asn Leu Xaa Val Val Asn Tyr Ser 
    530                 535                 540                 


Ser Ile Asn Arg Phe Met Lys Lys Leu Met Phe Pro Val Gly Tyr Gly 
545                 550                 555                 560 


Val Pro Ala Val Xaa Val Ala Ile Ser Ala Ala Ser Arg Pro His Leu 
                565                 570                 575     


Tyr Gly Xaa Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys Gly Phe Ile 
            580                 585                 590         


Trp Gly Phe Leu Gly Pro Val Cys Ala Ile Phe Ser Val Asn Leu Val 
        595                 600                 605             


Leu Phe Leu Val Xaa Leu Trp Ile Leu Lys Asn Arg Leu Ser Ser Leu 
    610                 615                 620                 


Asn Ser Glu Val Ser Xaa Leu Arg Asn Xaa Arg Met Leu Ala Phe Lys 
625                 630                 635                 640 


Ala Xaa Ala Gln Leu Phe Ile Leu Gly Cys Xaa Trp Cys Leu Gly Ile 
                645                 650                 655     


Leu Gln Val Gly Pro Ala Ala Arg Val Met Ala Tyr Leu Phe Xaa Ile 
            660                 665                 670         


Ile Asn Ser Leu Gln Gly Val Phe Ile Phe Leu Val Tyr Cys Leu Leu 
        675                 680                 685             


Ser Gln Gln Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys Gly Ile Arg 
    690                 695                 700                 


Lys Leu Lys Xaa Glu Ser Glu Met His Xaa Leu Ser Ser Ser Ala Lys 
705                 710                 715                 720 


Ala Asp Xaa Ser Lys Pro Ser Xaa Val Asn 
                725                 730 


<210> 1651
<211> 330
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<400> 1651
Xaa Phe Lys Asn Glu Ser Glu Asn Xaa Cys Gln Asp Val Asp Glu Cys 
1               5                   10                  15      


Gln Gln Asn Pro Arg Leu Cys Lys Ser Tyr Gly Xaa Cys Val Asn Xaa 
            20                  25                  30          


Leu Gly Ser Tyr Xaa Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro 
        35                  40                  45              


Glu Asp Pro Lys Leu Cys Xaa Asp Val Asp Glu Cys Ser Ser Gly Gln 
    50                  55                  60                  


His Gln Cys Asp Ser Ser Xaa Val Cys Phe Asn Xaa Val Gly Ser Tyr 
65                  70                  75                  80  


Ser Cys Arg Cys Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn 
                85                  90                  95      


Asn Gln Lys Asp Xaa Val Cys Glu Asp Met Xaa Phe Ser Xaa Trp Xaa 
            100                 105                 110         


Pro Pro Pro Gly Val His Ser Gln Xaa Leu Ser Arg Phe Phe Asp Lys 
        115                 120                 125             


Val Gln Asp Leu Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Xaa 
    130                 135                 140                 


Ile Gln Ser Ile Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly 
145                 150                 155                 160 


Asp Leu Glu Xaa Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His 
                165                 170                 175     


Leu Leu Asp Gly Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu 
            180                 185                 190         


Ser Asn Gly Leu Leu Asn Phe Ser Tyr Pro Ala Gly Xaa Glu Leu Ser 
        195                 200                 205             


Leu Glu Val Gln Lys Gln Val Asp Arg Ser Val Xaa Leu Arg Gln Asn 
    210                 215                 220                 


Gln Ala Val Met Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp 
225                 230                 235                 240 


Pro Val Ser Asp Pro Glu Xaa Glu Gly Ala Leu Cys Leu Leu Gly Ala 
                245                 250                 255     


Trp Pro Glu Trp Met Trp Ser Leu Gly His His Arg Leu Gln His Asn 
            260                 265                 270         


Arg His Gln Arg His Gln His His Leu Pro Leu His Pro Pro Glu Gln 
        275                 280                 285             


Leu Cys Arg Pro His Gly Pro Leu Arg Cys Ala Gly Gly Gly Ser Arg 
    290                 295                 300                 


Ala Asp Cys His His Leu His Gly Ala Glu Arg Leu Ser Ala Val Pro 
305                 310                 315                 320 


Pro Pro Gly Gly Pro His Phe Ser Pro Val 
                325                 330 


<210> 1652
<211> 437
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<400> 1652
Met Asn Ser Met Asp Ile Arg Cys Ser Asp Ile Ile Gln Gly Asp Xaa 
1               5                   10                  15      


Gln Gly Pro Ser Ala Ile Ala Phe Ile Ser Tyr Ser Ser Leu Gly Asn 
            20                  25                  30          


Ile Ile Asn Ala Xaa Phe Phe Glu Glu Met Asp Lys Lys Asp Gln Val 
        35                  40                  45              


Tyr Leu Asn Ser Gln Val Val Ser Ala Ala Ile Gly Pro Lys Arg Asn 
    50                  55                  60                  


Val Ser Leu Ser Lys Ser Val Xaa Leu Xaa Phe Gln His Val Lys Met 
65                  70                  75                  80  


Xaa Pro Ser Xaa Lys Lys Val Phe Cys Val Tyr Trp Lys Ser Xaa Gly 
                85                  90                  95      


Gln Gly Ser Gln Trp Ser Arg Asp Gly Cys Phe Leu Ile His Val Asn 
            100                 105                 110         


Lys Ser His Xaa Met Cys Asn Cys Ser His Leu Ser Ser Phe Ala Val 
        115                 120                 125             


Leu Met Ala Leu Xaa Ser Gln Glu Glu Asp Pro Val Leu Xaa Val Ile 
    130                 135                 140                 


Xaa Tyr Val Gly Leu Ser Val Ser Leu Leu Cys Leu Leu Leu Ala Ala 
145                 150                 155                 160 


Leu Xaa Phe Leu Leu Cys Lys Ala Ile Arg Asn Xaa Ser Xaa Ser Leu 
                165                 170                 175     


His Leu Gln Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu Phe Leu 
            180                 185                 190         


Val Gly Ile Asp Arg Xaa Glu Pro Lys Val Leu Cys Ser Ile Ile Ala 
        195                 200                 205             


Gly Ala Leu His Tyr Leu Tyr Leu Ala Ala Phe Xaa Trp Met Leu Leu 
    210                 215                 220                 


Glu Gly Val His Leu Phe Leu Xaa Ala Arg Asn Leu Xaa Val Val Asn 
225                 230                 235                 240 


Tyr Ser Ser Ile Asn Arg Leu Met Lys Trp Ile Met Phe Pro Val Gly 
                245                 250                 255     


Tyr Gly Val Pro Ala Val Xaa Val Ala Ile Ser Ala Ala Ser Trp Pro 
            260                 265                 270         


His Leu Tyr Gly Xaa Ala Asp Arg Cys Trp Leu His Leu Asp Gln Gly 
        275                 280                 285             


Phe Met Trp Ser Phe Leu Gly Pro Val Cys Ala Ile Phe Ser Ala Asn 
    290                 295                 300                 


Leu Val Leu Phe Ile Leu Val Phe Trp Ile Leu Lys Arg Lys Leu Ser 
305                 310                 315                 320 


Ser Leu Asn Ser Glu Val Ser Xaa Ile Gln Asn Xaa Arg Met Leu Ala 
                325                 330                 335     


Phe Lys Ala Xaa Ala Gln Leu Phe Ile Leu Gly Cys Xaa Trp Cys Leu 
            340                 345                 350         


Gly Leu Leu Gln Val Gly Pro Ala Ala Gln Val Met Ala Tyr Leu Phe 
        355                 360                 365             


Xaa Ile Ile Asn Ser Leu Gln Gly Phe Phe Ile Phe Leu Val Tyr Cys 
    370                 375                 380                 


Leu Leu Ser Gln Gln Val Gln Lys Gln Tyr Gln Lys Trp Phe Arg Glu 
385                 390                 395                 400 


Ile Val Lys Ser Lys Ser Glu Ser Glu Xaa Tyr Xaa Leu Ser Ser Lys 
                405                 410                 415     


Met Gly Pro Asp Ser Lys Pro Ser Glu Gly Asp Val Phe Pro Gly Gln 
            420                 425                 430         


Val Lys Arg Lys Tyr 
        435         


<210> 1653
<211> 57
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<400> 1653
Met Gln Gly Pro Leu Leu Leu Pro Gly Leu Cys Phe Leu Leu Ser Leu 
1               5                   10                  15      


Phe Gly Ala Val Xaa Gln Lys Xaa Lys Ser Glu Cys Ser Glu Pro Glu 
            20                  25                  30          


Gln Arg Xaa Cys Gly Pro Arg Ala Gly Pro Gly Ala Xaa His Gly Leu 
        35                  40                  45              


Gln Trp Ala Gly Glu Lys Cys Leu Phe 
    50                  55          


<210> 1654
<211> 526
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<400> 1654
Met Gln Gly Pro Leu Leu Leu Pro Gly Leu Cys Phe Leu Leu Ser Leu 
1               5                   10                  15      


Phe Gly Ala Val Xaa Gln Lys Xaa Lys Xaa Ser Cys Ala Lys Cys Pro 
            20                  25                  30          


Pro Asn Ala Ser Cys Val Asn Asn Xaa His Cys Xaa Cys Asn His Gly 
        35                  40                  45              


Tyr Xaa Ser Gly Ser Gly Gln Lys Leu Phe Xaa Phe Pro Leu Glu Xaa 
    50                  55                  60                  


Cys Asn Ala Ile Glu Xaa Gln Ala Ile Xaa Asp Asn Cys Ser Glu Glu 
65                  70                  75                  80  


Arg Lys Xaa Phe Asn Leu Asn Val Gln Met Asn Ser Met Asp Ile Arg 
                85                  90                  95      


Cys Ser Asp Ile Ile Gln Gly Asp Xaa Gln Gly Pro Ser Ala Ile Ala 
            100                 105                 110         


Phe Ile Ser Tyr Ser Ser Leu Gly Asn Ile Ile Asn Ala Xaa Phe Phe 
        115                 120                 125             


Glu Glu Met Asp Lys Lys Asp Gln Val Tyr Leu Asn Ser Gln Val Val 
    130                 135                 140                 


Ser Ala Ala Ile Gly Pro Lys Arg Asn Val Ser Leu Ser Lys Ser Val 
145                 150                 155                 160 


Xaa Leu Xaa Phe Gln His Val Lys Met Xaa Pro Ser Xaa Lys Lys Val 
                165                 170                 175     


Phe Cys Val Tyr Trp Lys Ser Xaa Gly Gln Gly Ser Gln Trp Ser Arg 
            180                 185                 190         


Asp Gly Cys Phe Leu Ile His Val Asn Lys Ser His Xaa Met Cys Asn 
        195                 200                 205             


Cys Ser His Leu Ser Ser Phe Ala Val Leu Met Ala Leu Xaa Ser Gln 
    210                 215                 220                 


Glu Glu Asp Pro Val Leu Xaa Val Ile Xaa Tyr Val Gly Leu Ser Val 
225                 230                 235                 240 


Ser Leu Leu Cys Leu Leu Leu Ala Ala Leu Xaa Phe Leu Leu Cys Lys 
                245                 250                 255     


Ala Ile Arg Asn Xaa Ser Xaa Ser Leu His Leu Gln Leu Ser Leu Cys 
            260                 265                 270         


Leu Phe Leu Ala His Leu Leu Phe Leu Val Gly Ile Asp Arg Xaa Glu 
        275                 280                 285             


Pro Lys Val Leu Cys Ser Ile Ile Ala Gly Ala Leu His Tyr Leu Tyr 
    290                 295                 300                 


Leu Ala Ala Phe Xaa Trp Met Leu Leu Glu Gly Val His Leu Phe Leu 
305                 310                 315                 320 


Xaa Ala Arg Asn Leu Xaa Val Val Asn Tyr Ser Ser Ile Asn Arg Leu 
                325                 330                 335     


Met Lys Trp Ile Met Phe Pro Val Gly Tyr Gly Val Pro Ala Val Xaa 
            340                 345                 350         


Val Ala Ile Ser Ala Ala Ser Trp Pro His Leu Tyr Gly Xaa Ala Asp 
        355                 360                 365             


Arg Cys Trp Leu His Leu Asp Gln Gly Phe Met Trp Ser Phe Leu Gly 
    370                 375                 380                 


Pro Val Cys Ala Ile Phe Ser Ala Asn Leu Val Leu Phe Ile Leu Val 
385                 390                 395                 400 


Phe Trp Ile Leu Lys Arg Lys Leu Ser Ser Leu Asn Ser Glu Val Ser 
                405                 410                 415     


Xaa Ile Gln Asn Xaa Arg Met Leu Ala Phe Lys Ala Xaa Ala Gln Leu 
            420                 425                 430         


Phe Ile Leu Gly Cys Xaa Trp Cys Leu Gly Leu Leu Gln Val Gly Pro 
        435                 440                 445             


Ala Ala Gln Val Met Ala Tyr Leu Phe Xaa Ile Ile Asn Ser Leu Gln 
    450                 455                 460                 


Gly Phe Phe Ile Phe Leu Val Tyr Cys Leu Leu Ser Gln Gln Val Gln 
465                 470                 475                 480 


Lys Gln Tyr Gln Lys Trp Phe Arg Glu Ile Val Lys Ser Lys Ser Glu 
                485                 490                 495     


Ser Glu Xaa Tyr Xaa Leu Ser Ser Lys Met Gly Pro Asp Ser Lys Pro 
            500                 505                 510         


Ser Glu Gly Asp Val Phe Pro Gly Gln Val Lys Arg Lys Tyr 
        515                 520                 525     


<210> 1655
<211> 652
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<400> 1655
Met Gln Gly Pro Leu Leu Leu Pro Gly Leu Cys Phe Leu Leu Ser Leu 
1               5                   10                  15      


Phe Gly Ala Val Xaa Gln Lys Xaa Lys Xaa Ser Cys Ala Lys Cys Pro 
            20                  25                  30          


Pro Asn Ala Ser Cys Val Asn Asn Xaa His Cys Xaa Cys Asn His Gly 
        35                  40                  45              


Tyr Xaa Ser Gly Ser Gly Gln Lys Leu Phe Xaa Phe Pro Leu Glu Xaa 
    50                  55                  60                  


Cys Asn Asp Ile Asn Glu Cys Xaa Pro Pro Tyr Ser Val Tyr Cys Gly 
65                  70                  75                  80  


Phe Asn Ala Val Cys Tyr Asn Val Glu Gly Ser Phe Tyr Cys Gln Cys 
                85                  90                  95      


Val Pro Gly Tyr Arg Leu His Ser Gly Asn Glu Gln Phe Ser Asn Ser 
            100                 105                 110         


Asn Glu Asn Xaa Cys Gln Asp Xaa Xaa Ser Ser Lys Xaa Xaa Glu Gly 
        115                 120                 125             


Arg Lys Glu Leu Gln Lys Ile Val Asp Lys Phe Glu Ser Leu Leu Xaa 
    130                 135                 140                 


Asn Gln Xaa Leu Trp Arg Xaa Glu Gly Arg Gln Glu Ile Ser Ser Xaa 
145                 150                 155                 160 


Ala Xaa Xaa Ile Leu Arg Asp Val Glu Ser Lys Val Leu Glu Xaa Ala 
                165                 170                 175     


Leu Lys Asp Pro Glu Gln Lys Val Leu Lys Ile Gln Asn Asp Ser Val 
            180                 185                 190         


Ala Ile Glu Xaa Gln Ala Ile Xaa Asp Asn Cys Ser Glu Glu Arg Lys 
        195                 200                 205             


Xaa Phe Asn Leu Asn Val Gln Met Asn Ser Met Asp Ile Arg Cys Ser 
    210                 215                 220                 


Asp Ile Ile Gln Gly Asp Xaa Gln Gly Pro Ser Ala Ile Ala Phe Ile 
225                 230                 235                 240 


Ser Tyr Ser Ser Leu Gly Asn Ile Ile Asn Ala Xaa Phe Phe Glu Glu 
                245                 250                 255     


Met Asp Lys Lys Asp Gln Val Tyr Leu Asn Ser Gln Val Val Ser Ala 
            260                 265                 270         


Ala Ile Gly Pro Lys Arg Asn Val Ser Leu Ser Lys Ser Val Xaa Leu 
        275                 280                 285             


Xaa Phe Gln His Val Lys Met Xaa Pro Ser Xaa Lys Lys Val Phe Cys 
    290                 295                 300                 


Val Tyr Trp Lys Ser Xaa Gly Gln Gly Ser Gln Trp Ser Arg Asp Gly 
305                 310                 315                 320 


Cys Phe Leu Ile His Val Asn Lys Ser His Xaa Met Cys Asn Cys Ser 
                325                 330                 335     


His Leu Ser Ser Phe Ala Val Leu Met Ala Leu Xaa Ser Gln Glu Glu 
            340                 345                 350         


Asp Pro Val Leu Xaa Val Ile Xaa Tyr Val Gly Leu Ser Val Ser Leu 
        355                 360                 365             


Leu Cys Leu Leu Leu Ala Ala Leu Xaa Phe Leu Leu Cys Lys Ala Ile 
    370                 375                 380                 


Arg Asn Xaa Ser Xaa Ser Leu His Leu Gln Leu Ser Leu Cys Leu Phe 
385                 390                 395                 400 


Leu Ala His Leu Leu Phe Leu Val Gly Ile Asp Arg Xaa Glu Pro Lys 
                405                 410                 415     


Val Leu Cys Ser Ile Ile Ala Gly Ala Leu His Tyr Leu Tyr Leu Ala 
            420                 425                 430         


Ala Phe Xaa Trp Met Leu Leu Glu Gly Val His Leu Phe Leu Xaa Ala 
        435                 440                 445             


Arg Asn Leu Xaa Val Val Asn Tyr Ser Ser Ile Asn Arg Leu Met Lys 
    450                 455                 460                 


Trp Ile Met Phe Pro Val Gly Tyr Gly Val Pro Ala Val Xaa Val Ala 
465                 470                 475                 480 


Ile Ser Ala Ala Ser Trp Pro His Leu Tyr Gly Xaa Ala Asp Arg Cys 
                485                 490                 495     


Trp Leu His Leu Asp Gln Gly Phe Met Trp Ser Phe Leu Gly Pro Val 
            500                 505                 510         


Cys Ala Ile Phe Ser Ala Asn Leu Val Leu Phe Ile Leu Val Phe Trp 
        515                 520                 525             


Ile Leu Lys Arg Lys Leu Ser Ser Leu Asn Ser Glu Val Ser Xaa Ile 
    530                 535                 540                 


Gln Asn Xaa Arg Met Leu Ala Phe Lys Ala Xaa Ala Gln Leu Phe Ile 
545                 550                 555                 560 


Leu Gly Cys Xaa Trp Cys Leu Gly Leu Leu Gln Val Gly Pro Ala Ala 
                565                 570                 575     


Gln Val Met Ala Tyr Leu Phe Xaa Ile Ile Asn Ser Leu Gln Gly Phe 
            580                 585                 590         


Phe Ile Phe Leu Val Tyr Cys Leu Leu Ser Gln Gln Val Gln Lys Gln 
        595                 600                 605             


Tyr Gln Lys Trp Phe Arg Glu Ile Val Lys Ser Lys Ser Glu Ser Glu 
    610                 615                 620                 


Xaa Tyr Xaa Leu Ser Ser Lys Met Gly Pro Asp Ser Lys Pro Ser Glu 
625                 630                 635                 640 


Gly Asp Val Phe Pro Gly Gln Val Lys Arg Lys Tyr 
                645                 650         


<210> 1656
<211> 600
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<400> 1656
Met Gln Gly Pro Leu Leu Leu Pro Gly Leu Cys Phe Leu Leu Ser Leu 
1               5                   10                  15      


Phe Gly Ala Val Xaa Gln Lys Xaa Lys Xaa Ser Cys Ala Lys Cys Pro 
            20                  25                  30          


Pro Asn Ala Ser Cys Val Asn Asn Xaa His Cys Xaa Cys Asn His Gly 
        35                  40                  45              


Tyr Xaa Ser Gly Ser Gly Gln Lys Leu Phe Xaa Phe Pro Leu Glu Xaa 
    50                  55                  60                  


Cys Asn Asp Xaa Xaa Ser Ser Lys Xaa Xaa Glu Gly Arg Lys Glu Leu 
65                  70                  75                  80  


Gln Lys Ile Val Asp Lys Phe Glu Ser Leu Leu Xaa Asn Gln Xaa Leu 
                85                  90                  95      


Trp Arg Xaa Glu Gly Arg Gln Glu Ile Ser Ser Xaa Ala Xaa Xaa Ile 
            100                 105                 110         


Leu Arg Asp Val Glu Ser Lys Val Leu Glu Xaa Ala Leu Lys Asp Pro 
        115                 120                 125             


Glu Gln Lys Val Leu Lys Ile Gln Asn Asp Ser Val Ala Ile Glu Xaa 
    130                 135                 140                 


Gln Ala Ile Xaa Asp Asn Cys Ser Glu Glu Arg Lys Xaa Phe Asn Leu 
145                 150                 155                 160 


Asn Val Gln Met Asn Ser Met Asp Ile Arg Cys Ser Asp Ile Ile Gln 
                165                 170                 175     


Gly Asp Xaa Gln Gly Pro Ser Ala Ile Ala Phe Ile Ser Tyr Ser Ser 
            180                 185                 190         


Leu Gly Asn Ile Ile Asn Ala Xaa Phe Phe Glu Glu Met Asp Lys Lys 
        195                 200                 205             


Asp Gln Val Tyr Leu Asn Ser Gln Val Val Ser Ala Ala Ile Gly Pro 
    210                 215                 220                 


Lys Arg Asn Val Ser Leu Ser Lys Ser Val Xaa Leu Xaa Phe Gln His 
225                 230                 235                 240 


Val Lys Met Xaa Pro Ser Xaa Lys Lys Val Phe Cys Val Tyr Trp Lys 
                245                 250                 255     


Ser Xaa Gly Gln Gly Ser Gln Trp Ser Arg Asp Gly Cys Phe Leu Ile 
            260                 265                 270         


His Val Asn Lys Ser His Xaa Met Cys Asn Cys Ser His Leu Ser Ser 
        275                 280                 285             


Phe Ala Val Leu Met Ala Leu Xaa Ser Gln Glu Glu Asp Pro Val Leu 
    290                 295                 300                 


Xaa Val Ile Xaa Tyr Val Gly Leu Ser Val Ser Leu Leu Cys Leu Leu 
305                 310                 315                 320 


Leu Ala Ala Leu Xaa Phe Leu Leu Cys Lys Ala Ile Arg Asn Xaa Ser 
                325                 330                 335     


Xaa Ser Leu His Leu Gln Leu Ser Leu Cys Leu Phe Leu Ala His Leu 
            340                 345                 350         


Leu Phe Leu Val Gly Ile Asp Arg Xaa Glu Pro Lys Val Leu Cys Ser 
        355                 360                 365             


Ile Ile Ala Gly Ala Leu His Tyr Leu Tyr Leu Ala Ala Phe Xaa Trp 
    370                 375                 380                 


Met Leu Leu Glu Gly Val His Leu Phe Leu Xaa Ala Arg Asn Leu Xaa 
385                 390                 395                 400 


Val Val Asn Tyr Ser Ser Ile Asn Arg Leu Met Lys Trp Ile Met Phe 
                405                 410                 415     


Pro Val Gly Tyr Gly Val Pro Ala Val Xaa Val Ala Ile Ser Ala Ala 
            420                 425                 430         


Ser Trp Pro His Leu Tyr Gly Xaa Ala Asp Arg Cys Trp Leu His Leu 
        435                 440                 445             


Asp Gln Gly Phe Met Trp Ser Phe Leu Gly Pro Val Cys Ala Ile Phe 
    450                 455                 460                 


Ser Ala Asn Leu Val Leu Phe Ile Leu Val Phe Trp Ile Leu Lys Arg 
465                 470                 475                 480 


Lys Leu Ser Ser Leu Asn Ser Glu Val Ser Xaa Ile Gln Asn Xaa Arg 
                485                 490                 495     


Met Leu Ala Phe Lys Ala Xaa Ala Gln Leu Phe Ile Leu Gly Cys Xaa 
            500                 505                 510         


Trp Cys Leu Gly Leu Leu Gln Val Gly Pro Ala Ala Gln Val Met Ala 
        515                 520                 525             


Tyr Leu Phe Xaa Ile Ile Asn Ser Leu Gln Gly Phe Phe Ile Phe Leu 
    530                 535                 540                 


Val Tyr Cys Leu Leu Ser Gln Gln Val Gln Lys Gln Tyr Gln Lys Trp 
545                 550                 555                 560 


Phe Arg Glu Ile Val Lys Ser Lys Ser Glu Ser Glu Xaa Tyr Xaa Leu 
                565                 570                 575     


Ser Ser Lys Met Gly Pro Asp Ser Lys Pro Ser Glu Gly Asp Val Phe 
            580                 585                 590         


Pro Gly Gln Val Lys Arg Lys Tyr 
        595                 600 


<210> 1657
<211> 786
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<400> 1657
Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Xaa Leu Pro 
1               5                   10                  15      


Gly Ala Glu Xaa Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln 
            20                  25                  30          


Asn Ser Ser Cys Val Asn Ala Xaa Ala Cys Arg Cys Asn Pro Gly Phe 
        35                  40                  45              


Ser Ser Phe Ser Glu Ile Ile Xaa Xaa Pro Xaa Glu Xaa Cys Asp Asp 
    50                  55                  60                  


Ile Asn Glu Cys Ala Xaa Pro Ser Lys Val Ser Cys Gly Lys Phe Ser 
65                  70                  75                  80  


Asp Cys Trp Asn Xaa Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly 
                85                  90                  95      


Tyr Glu Pro Val Ser Gly Ala Lys Xaa Phe Lys Asn Glu Ser Glu Asn 
            100                 105                 110         


Xaa Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg Leu Cys Lys 
        115                 120                 125             


Ser Tyr Gly Xaa Cys Val Asn Xaa Leu Gly Ser Tyr Xaa Cys Gln Cys 
    130                 135                 140                 


Leu Pro Gly Phe Lys Phe Ile Pro Glu Asp Pro Lys Val Cys Xaa Asp 
145                 150                 155                 160 


Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Xaa Val 
                165                 170                 175     


Cys Phe Asn Xaa Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly Trp 
            180                 185                 190         


Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Xaa Val Cys Glu 
        195                 200                 205             


Asp Met Xaa Phe Ser Xaa Trp Xaa Pro Pro Pro Gly Val His Ser Gln 
    210                 215                 220                 


Xaa Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp Ser 
225                 230                 235                 240 


Lys Xaa Ser Ser Ala Glu Val Xaa Ile Gln Asn Val Ile Lys Leu Val 
                245                 250                 255     


Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala Leu Ala Pro Pro 
            260                 265                 270         


Val Arg His Leu Ile Ala Xaa Gln Leu Leu Ser Asn Leu Glu Asp Ile 
        275                 280                 285             


Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro Phe Xaa Tyr Ile 
    290                 295                 300                 


Ser Pro Ser Asn Xaa Glu Leu Xaa Leu Met Ile Gln Glu Arg Gly Asp 
305                 310                 315                 320 


Lys Asn Val Xaa Met Gly Gln Ser Ser Ala Arg Met Lys Leu Asn Trp 
                325                 330                 335     


Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala Val Ala Gly Ile 
            340                 345                 350         


Leu Ser Ile Gln Asn Met Xaa Xaa Leu Leu Ala Asn Ala Ser Leu Asn 
        355                 360                 365             


Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile Tyr Glu Ser Ser 
    370                 375                 380                 


Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val Asn Ser Ile Phe 
385                 390                 395                 400 


Leu Ser His Asn Asn Xaa Lys Glu Leu Asn Ser Pro Ile Leu Phe Ala 
                405                 410                 415     


Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly Arg Asp Pro Pro 
            420                 425                 430         


Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu Leu Cys Ala Phe 
        435                 440                 445             


Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala Xaa Glu Gly Cys 
    450                 455                 460                 


Gln Val Leu Gly Ser Lys Asn Gly Ser Xaa Xaa Cys Gln Cys Ser His 
465                 470                 475                 480 


Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp Val Glu Asp Trp 
                485                 490                 495     


Lys Leu Xaa Leu Ile Xaa Arg Val Gly Leu Ala Leu Ser Leu Phe Cys 
            500                 505                 510         


Leu Leu Leu Cys Ile Leu Xaa Phe Leu Leu Val Arg Pro Ile Gln Gly 
        515                 520                 525             


Ser Arg Xaa Xaa Ile His Leu His Leu Cys Ile Cys Leu Phe Val Gly 
    530                 535                 540                 


Ser Xaa Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly Gly Gln Val Gly 
545                 550                 555                 560 


Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr Cys Phe Leu Ala 
                565                 570                 575     


Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu Tyr Phe Leu Val 
            580                 585                 590         


Val Arg Val Phe Gln Gly Gln Gly Leu Ser Xaa Arg Trp Leu Cys Leu 
        595                 600                 605             


Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val Ser Ala Ala Ile 
    610                 615                 620                 


Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp Leu Asp Phe Glu 
625                 630                 635                 640 


Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Xaa Phe Ile Ile Leu 
                645                 650                 655     


Cys Asn Ala Val Ile Phe Val Xaa Xaa Val Trp Lys Leu Xaa Gln Lys 
            660                 665                 670         


Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys Lys Ala Arg Ala 
        675                 680                 685             


Leu Xaa Ile Xaa Ala Ile Ala Gln Leu Phe Leu Leu Gly Cys Xaa Trp 
    690                 695                 700                 


Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu Val Leu Xaa Tyr 
705                 710                 715                 720 


Val Phe Xaa Ile Leu Asn Cys Leu Gln Gly Ala Phe Leu Tyr Leu Leu 
                725                 730                 735     


His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr Arg Lys Trp Ala 
            740                 745                 750         


Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe Xaa Ser Xaa Xaa 
        755                 760                 765             


Ser Gly Xaa Gly His Asn Gln Xaa Arg Ala Leu Arg Ala Ser Glu Ser 
    770                 775                 780                 


Gly Ile 
785     


<210> 1658
<211> 835
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<400> 1658
Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Xaa Leu Pro 
1               5                   10                  15      


Gly Ala Glu Xaa Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln 
            20                  25                  30          


Asn Ser Ser Cys Val Asn Ala Xaa Ala Cys Arg Cys Asn Pro Gly Phe 
        35                  40                  45              


Ser Ser Phe Ser Glu Ile Ile Xaa Xaa Pro Xaa Glu Xaa Cys Asp Asp 
    50                  55                  60                  


Ile Asn Glu Cys Ala Xaa Pro Ser Lys Val Ser Cys Gly Lys Phe Ser 
65                  70                  75                  80  


Asp Cys Trp Asn Xaa Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly 
                85                  90                  95      


Tyr Glu Pro Val Ser Gly Ala Lys Xaa Phe Lys Asn Glu Ser Glu Asn 
            100                 105                 110         


Xaa Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg Leu Cys Lys 
        115                 120                 125             


Ser Tyr Gly Xaa Cys Val Asn Xaa Leu Gly Ser Tyr Xaa Cys Gln Cys 
    130                 135                 140                 


Leu Pro Gly Phe Lys Phe Ile Pro Glu Asp Pro Lys Val Cys Xaa Asp 
145                 150                 155                 160 


Val Asn Glu Cys Xaa Ser Gly Gln Asn Pro Cys His Ser Ser Xaa His 
                165                 170                 175     


Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg Pro Gly Trp 
            180                 185                 190         


Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Xaa Val Cys Glu 
        195                 200                 205             


Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Xaa 
    210                 215                 220                 


Val Cys Phe Asn Xaa Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly 
225                 230                 235                 240 


Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Xaa Val Cys 
                245                 250                 255     


Glu Asp Met Xaa Phe Ser Xaa Trp Xaa Pro Pro Pro Gly Val His Ser 
            260                 265                 270         


Gln Xaa Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp 
        275                 280                 285             


Ser Lys Xaa Ser Ser Ala Glu Val Xaa Ile Gln Asn Val Ile Lys Leu 
    290                 295                 300                 


Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala Leu Ala Pro 
305                 310                 315                 320 


Pro Val Arg His Leu Ile Ala Xaa Gln Leu Leu Ser Asn Leu Glu Asp 
                325                 330                 335     


Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro Phe Xaa Tyr 
            340                 345                 350         


Ile Ser Pro Ser Asn Xaa Glu Leu Xaa Leu Met Ile Gln Glu Arg Gly 
        355                 360                 365             


Asp Lys Asn Val Xaa Met Gly Gln Ser Ser Ala Arg Met Lys Leu Asn 
    370                 375                 380                 


Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala Val Ala Gly 
385                 390                 395                 400 


Ile Leu Ser Ile Gln Asn Met Xaa Xaa Leu Leu Ala Asn Ala Ser Leu 
                405                 410                 415     


Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile Tyr Glu Ser 
            420                 425                 430         


Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val Asn Ser Ile 
        435                 440                 445             


Phe Leu Ser His Asn Asn Xaa Lys Glu Leu Asn Ser Pro Ile Leu Phe 
    450                 455                 460                 


Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly Arg Asp Pro 
465                 470                 475                 480 


Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu Leu Cys Ala 
                485                 490                 495     


Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala Xaa Glu Gly 
            500                 505                 510         


Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Xaa Xaa Cys Gln Cys Ser 
        515                 520                 525             


His Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp Val Glu Asp 
    530                 535                 540                 


Trp Lys Leu Xaa Leu Ile Xaa Arg Val Gly Leu Ala Leu Ser Leu Phe 
545                 550                 555                 560 


Cys Leu Leu Leu Cys Ile Leu Xaa Phe Leu Leu Val Arg Pro Ile Gln 
                565                 570                 575     


Gly Ser Arg Xaa Xaa Ile His Leu His Leu Cys Ile Cys Leu Phe Val 
            580                 585                 590         


Gly Ser Xaa Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly Gly Gln Val 
        595                 600                 605             


Gly Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr Cys Phe Leu 
    610                 615                 620                 


Ala Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu Tyr Phe Leu 
625                 630                 635                 640 


Val Val Arg Val Phe Gln Gly Gln Gly Leu Ser Xaa Arg Trp Leu Cys 
                645                 650                 655     


Leu Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val Ser Ala Ala 
            660                 665                 670         


Ile Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp Leu Asp Phe 
        675                 680                 685             


Glu Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Xaa Phe Ile Ile 
    690                 695                 700                 


Leu Cys Asn Ala Val Ile Phe Val Xaa Xaa Val Trp Lys Leu Xaa Gln 
705                 710                 715                 720 


Lys Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys Lys Ala Arg 
                725                 730                 735     


Ala Leu Xaa Ile Xaa Ala Ile Ala Gln Leu Phe Leu Leu Gly Cys Xaa 
            740                 745                 750         


Trp Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu Val Leu Xaa 
        755                 760                 765             


Tyr Val Phe Xaa Ile Leu Asn Cys Leu Gln Gly Ala Phe Leu Tyr Leu 
    770                 775                 780                 


Leu His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr Arg Lys Trp 
785                 790                 795                 800 


Ala Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe Xaa Ser Xaa 
                805                 810                 815     


Xaa Ser Gly Xaa Gly His Asn Gln Xaa Arg Ala Leu Arg Ala Ser Glu 
            820                 825                 830         


Ser Gly Ile 
        835 


<210> 1659
<211> 742
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<400> 1659
Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Xaa Leu Pro 
1               5                   10                  15      


Gly Ala Glu Xaa Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln 
            20                  25                  30          


Asn Ser Ser Cys Val Asn Ala Xaa Ala Cys Arg Cys Asn Pro Gly Phe 
        35                  40                  45              


Ser Ser Phe Ser Glu Ile Ile Xaa Xaa Pro Xaa Glu Xaa Cys Asp Asp 
    50                  55                  60                  


Ile Asn Glu Cys Ala Xaa Pro Ser Lys Val Ser Cys Gly Lys Phe Ser 
65                  70                  75                  80  


Asp Cys Trp Asn Xaa Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly 
                85                  90                  95      


Tyr Glu Pro Val Ser Gly Ala Lys Xaa Phe Lys Asn Glu Ser Glu Asn 
            100                 105                 110         


Xaa Cys Gln Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
        115                 120                 125             


Ser Ser Xaa Val Cys Phe Asn Xaa Val Gly Ser Tyr Ser Cys Arg Cys 
    130                 135                 140                 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
145                 150                 155                 160 


Xaa Val Cys Glu Asp Met Xaa Phe Ser Xaa Trp Xaa Pro Pro Pro Gly 
                165                 170                 175     


Val His Ser Gln Xaa Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
            180                 185                 190         


Gly Arg Asp Ser Lys Xaa Ser Ser Ala Glu Val Xaa Ile Gln Asn Val 
        195                 200                 205             


Ile Lys Leu Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala 
    210                 215                 220                 


Leu Ala Pro Pro Val Arg His Leu Ile Ala Xaa Gln Leu Leu Ser Asn 
225                 230                 235                 240 


Leu Glu Asp Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro 
                245                 250                 255     


Phe Xaa Tyr Ile Ser Pro Ser Asn Xaa Glu Leu Xaa Leu Met Ile Gln 
            260                 265                 270         


Glu Arg Gly Asp Lys Asn Val Xaa Met Gly Gln Ser Ser Ala Arg Met 
        275                 280                 285             


Lys Leu Asn Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala 
    290                 295                 300                 


Val Ala Gly Ile Leu Ser Ile Gln Asn Met Xaa Xaa Leu Leu Ala Asn 
305                 310                 315                 320 


Ala Ser Leu Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile 
                325                 330                 335     


Tyr Glu Ser Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val 
            340                 345                 350         


Asn Ser Ile Phe Leu Ser His Asn Asn Xaa Lys Glu Leu Asn Ser Pro 
        355                 360                 365             


Ile Leu Phe Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly 
    370                 375                 380                 


Arg Asp Pro Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu 
385                 390                 395                 400 


Leu Cys Ala Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala 
                405                 410                 415     


Xaa Glu Gly Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Xaa Xaa Cys 
            420                 425                 430         


Gln Cys Ser His Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp 
        435                 440                 445             


Val Glu Asp Trp Lys Leu Xaa Leu Ile Xaa Arg Val Gly Leu Ala Leu 
    450                 455                 460                 


Ser Leu Phe Cys Leu Leu Leu Cys Ile Leu Xaa Phe Leu Leu Val Arg 
465                 470                 475                 480 


Pro Ile Gln Gly Ser Arg Xaa Xaa Ile His Leu His Leu Cys Ile Cys 
                485                 490                 495     


Leu Phe Val Gly Ser Xaa Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly 
            500                 505                 510         


Gly Gln Val Gly Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr 
        515                 520                 525             


Cys Phe Leu Ala Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu 
    530                 535                 540                 


Tyr Phe Leu Val Val Arg Val Phe Gln Gly Gln Gly Leu Ser Xaa Arg 
545                 550                 555                 560 


Trp Leu Cys Leu Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val 
                565                 570                 575     


Ser Ala Ala Ile Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp 
            580                 585                 590         


Leu Asp Phe Glu Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Xaa 
        595                 600                 605             


Phe Ile Ile Leu Cys Asn Ala Val Ile Phe Val Xaa Xaa Val Trp Lys 
    610                 615                 620                 


Leu Xaa Gln Lys Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys 
625                 630                 635                 640 


Lys Ala Arg Ala Leu Xaa Ile Xaa Ala Ile Ala Gln Leu Phe Leu Leu 
                645                 650                 655     


Gly Cys Xaa Trp Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu 
            660                 665                 670         


Val Leu Xaa Tyr Val Phe Xaa Ile Leu Asn Cys Leu Gln Gly Ala Phe 
        675                 680                 685             


Leu Tyr Leu Leu His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr 
    690                 695                 700                 


Arg Lys Trp Ala Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe 
705                 710                 715                 720 


Xaa Ser Xaa Xaa Ser Gly Xaa Gly His Asn Gln Xaa Arg Ala Leu Arg 
                725                 730                 735     


Ala Ser Glu Ser Gly Ile 
            740         


<210> 1660
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<400> 1660
Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Xaa Leu Pro 
1               5                   10                  15      


Gly Ala Glu Xaa Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln 
            20                  25                  30          


Asn Ser Ser Cys Val Asn Ala Xaa Ala Cys Arg Cys Asn Pro Gly Phe 
        35                  40                  45              


Ser Ser Phe Ser Glu Ile Ile Xaa Xaa Pro Xaa Glu Xaa Cys Asp Asp 
    50                  55                  60                  


Ile Asn Glu Cys Ala Xaa Pro Ser Lys Val Ser Cys Gly Lys Phe Ser 
65                  70                  75                  80  


Asp Cys Trp Asn Xaa Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly 
                85                  90                  95      


Tyr Glu Pro Val Ser Gly Ala Lys Xaa Phe Lys Asn Glu Ser Glu Asn 
            100                 105                 110         


Xaa Cys Gln Asp Val Asn Glu Cys Xaa Ser Gly Gln Asn Pro Cys His 
        115                 120                 125             


Ser Ser Xaa His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys 
    130                 135                 140                 


Arg Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn 
145                 150                 155                 160 


Xaa Val Cys Glu 
                


<210> 1661
<211> 154
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<400> 1661
Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Xaa Leu Pro 
1               5                   10                  15      


Gly Ala Glu Xaa Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln 
            20                  25                  30          


Asn Ser Ser Cys Val Asn Ala Xaa Ala Cys Arg Cys Asn Pro Gly Phe 
        35                  40                  45              


Ser Ser Phe Ser Glu Ile Ile Xaa Xaa Pro Xaa Glu Xaa Cys Asp Asp 
    50                  55                  60                  


Ile Asn Glu Cys Ala Xaa Pro Ser Lys Val Ser Cys Gly Lys Phe Ser 
65                  70                  75                  80  


Asp Cys Trp Asn Xaa Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly 
                85                  90                  95      


Tyr Glu Pro Val Ser Gly Ala Lys Xaa Phe Lys Asn Glu Ser Glu Asn 
            100                 105                 110         


Xaa Cys Gln Gly Lys Asn His Pro Xaa Ser Ser Asp Phe Pro Ser Met 
        115                 120                 125             


Arg Phe Gly Val Xaa Arg Ala Ile Leu Ala Ala Ser Arg Glu Gln Gly 
    130                 135                 140                 


Leu Gly Cys Arg Val Ser Ala Trp Arg Leu 
145                 150                 


<210> 1662
<211> 157
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<400> 1662
Met Gly Gly Arg Val Phe Leu Gly Cys Ala Arg Trp Cys Pro Gln Asn 
1               5                   10                  15      


Ser Ser Cys Val Asn Ala Xaa Ala Cys Arg Cys Asn Pro Gly Phe Ser 
            20                  25                  30          


Ser Phe Ser Glu Ile Ile Xaa Xaa Pro Xaa Glu Xaa Cys Asp Asp Ile 
        35                  40                  45              


Asn Glu Cys Ala Xaa Pro Ser Lys Val Ser Cys Gly Lys Phe Ser Asp 
    50                  55                  60                  


Cys Trp Asn Xaa Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly Tyr 
65                  70                  75                  80  


Glu Pro Val Ser Gly Ala Lys Xaa Phe Lys Asn Glu Ser Glu Asn Xaa 
                85                  90                  95      


Cys Gln Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser 
            100                 105                 110         


Ser Xaa Val Cys Phe Asn Xaa Val Gly Ser Tyr Ser Cys Arg Cys Arg 
        115                 120                 125             


Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Xaa 
    130                 135                 140                 


Val Cys Glu Asp Met Xaa Phe Ser Xaa Trp Xaa Pro Pro 
145                 150                 155         


<210> 1663
<211> 160
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<400> 1663
Glu Tyr Gln Leu Leu Leu Gln Val Xaa Tyr Arg Asp Ser Lys Glu Lys 
1               5                   10                  15      


Arg Asp Leu Arg Asn Phe Leu Lys Leu Leu Lys Pro Pro Leu Leu Trp 
            20                  25                  30          


Ser His Gly Leu Ile Arg Ile Ile Arg Ala Lys Ala Xaa Xaa Asp Cys 
        35                  40                  45              


Asn Ser Leu Asn Gly Val Leu Gln Cys Xaa Cys Glu Asp Ser Tyr Xaa 
    50                  55                  60                  


Trp Phe Pro Pro Ser Cys Leu Asp Pro Gln Asn Cys Tyr Leu His Xaa 
65                  70                  75                  80  


Ala Gly Ala Leu Pro Ser Cys Glu Cys His Leu Asn Asn Leu Ser Gln 
                85                  90                  95      


Ser Val Asn Phe Cys Glu Arg Xaa Lys Ile Trp Gly Xaa Phe Lys Ile 
            100                 105                 110         


Asn Glu Arg Phe Xaa Asn Asp Leu Leu Asn Ser Ser Ser Ala Ile Tyr 
        115                 120                 125             


Ser Lys Tyr Ala Asn Gly Ile Glu Ile Gln Leu Lys Lys Ala Tyr Glu 
    130                 135                 140                 


Arg Ile Gln Gly Phe Glu Ser Val Gln Val Xaa Gln Phe Arg Pro Val 
145                 150                 155                 160 


<210> 1664
<211> 713
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<400> 1664
Met Asp Ile Ser Ile Gln Arg Asn Gly Ser Ile Val Ala Gly Tyr Glu 
1               5                   10                  15      


Val Val Gly Ser Ser Ser Ala Ser Glu Leu Leu Ser Ala Ile Glu His 
            20                  25                  30          


Val Ala Glu Lys Ala Lys Xaa Ala Leu His Lys Leu Phe Pro Leu Glu 
        35                  40                  45              


Asp Gly Ser Phe Arg Val Phe Gly Lys Ala Gln Cys Asn Asp Ile Val 
    50                  55                  60                  


Phe Gly Phe Gly Ser Lys Asp Asp Glu Tyr Xaa Leu Pro Cys Ser Ser 
65                  70                  75                  80  


Gly Tyr Arg Gly Asn Ile Xaa Ala Lys Cys Glu Ser Ser Gly Trp Gln 
                85                  90                  95      


Val Ile Arg Glu Xaa Cys Val Leu Ser Leu Leu Glu Glu Leu Asn Lys 
            100                 105                 110         


Asn Phe Ser Met Ile Val Gly Asn Ala Xaa Glu Ala Ala Val Ser Ser 
        115                 120                 125             


Phe Val Gln Asn Leu Ser Val Ile Ile Arg Gln Asn Pro Ser Xaa Xaa 
    130                 135                 140                 


Val Gly Asn Leu Ala Ser Val Val Ser Ile Leu Ser Asn Ile Ser Ser 
145                 150                 155                 160 


Leu Ser Leu Ala Ser His Phe Arg Val Ser Asn Ser Xaa Met Glu Asp 
                165                 170                 175     


Val Ile Ser Ile Ala Asp Asn Ile Leu Asn Ser Ala Ser Val Xaa Asn 
            180                 185                 190         


Trp Xaa Val Leu Leu Arg Glu Glu Lys Tyr Ala Ser Ser Arg Leu Leu 
        195                 200                 205             


Glu Xaa Leu Glu Asn Ile Ser Xaa Leu Val Pro Pro Xaa Ala Leu Pro 
    210                 215                 220                 


Leu Asn Phe Ser Arg Lys Phe Ile Asp Trp Lys Gly Ile Pro Val Asn 
225                 230                 235                 240 


Lys Ser Gln Leu Lys Arg Gly Tyr Ser Tyr Gln Ile Lys Met Cys Pro 
                245                 250                 255     


Gln Asn Xaa Ser Ile Pro Ile Arg Gly Arg Val Leu Ile Gly Ser Asp 
            260                 265                 270         


Gln Phe Gln Arg Ser Leu Pro Glu Xaa Ile Ile Ser Met Ala Ser Leu 
        275                 280                 285             


Xaa Leu Gly Asn Ile Leu Pro Val Ser Lys Asn Gly Asn Ala Gln Val 
    290                 295                 300                 


Asn Gly Pro Val Ile Ser Xaa Val Ile Gln Asn Tyr Ser Ile Asn Glu 
305                 310                 315                 320 


Val Phe Leu Phe Phe Ser Lys Ile Glu Ser Asn Leu Ser Gln Pro His 
                325                 330                 335     


Cys Val Phe Trp Asp Phe Ser His Leu Gln Trp Asn Asp Ala Gly Cys 
            340                 345                 350         


His Leu Val Asn Glu Xaa Gln Asp Ile Val Xaa Cys Gln Cys Xaa His 
        355                 360                 365             


Leu Xaa Ser Phe Ser Ile Leu Met Ser Pro Phe Val Pro Ser Xaa Ile 
    370                 375                 380                 


Phe Pro Val Val Lys Trp Ile Xaa Tyr Val Gly Leu Gly Ile Ser Ile 
385                 390                 395                 400 


Gly Ser Leu Ile Leu Cys Leu Ile Ile Glu Ala Leu Phe Trp Lys Gln 
                405                 410                 415     


Ile Lys Lys Ser Gln Xaa Ser His Xaa Arg Arg Ile Cys Met Val Asn 
            420                 425                 430         


Ile Ala Leu Ser Leu Leu Ile Ala Asp Val Trp Phe Ile Val Gly Ala 
        435                 440                 445             


Xaa Val Asp Xaa Xaa Val Asn Pro Ser Gly Val Cys Xaa Ala Ala Val 
    450                 455                 460                 


Phe Phe Xaa His Phe Phe Tyr Leu Ser Leu Phe Phe Trp Met Leu Met 
465                 470                 475                 480 


Leu Gly Ile Leu Leu Ala Tyr Arg Ile Ile Leu Val Phe His His Met 
                485                 490                 495     


Ala Gln His Leu Met Met Ala Val Gly Phe Cys Leu Gly Tyr Gly Cys 
            500                 505                 510         


Pro Leu Ile Ile Ser Val Ile Xaa Ile Ala Val Xaa Gln Pro Ser Asn 
        515                 520                 525             


Xaa Tyr Lys Arg Lys Asp Val Cys Trp Leu Asn Trp Ser Asn Gly Ser 
    530                 535                 540                 


Lys Pro Leu Leu Ala Phe Val Val Pro Ala Leu Ala Ile Val Ala Val 
545                 550                 555                 560 


Asn Phe Val Val Val Leu Leu Val Leu Xaa Lys Leu Trp Arg Pro Xaa 
                565                 570                 575     


Val Gly Glu Arg Leu Ser Arg Asp Asp Lys Ala Xaa Ile Ile Arg Val 
            580                 585                 590         


Gly Lys Ser Leu Leu Ile Leu Xaa Pro Leu Leu Gly Leu Xaa Trp Gly 
        595                 600                 605             


Phe Gly Ile Gly Xaa Ile Val Asp Ser Gln Asn Leu Ala Trp His Val 
    610                 615                 620                 


Ile Phe Ala Leu Leu Asn Ala Phe Gln Gly Phe Phe Ile Leu Cys Phe 
625                 630                 635                 640 


Gly Ile Leu Leu Asp Ser Lys Leu Arg Gln Leu Leu Phe Asn Lys Leu 
                645                 650                 655     


Ser Ala Leu Ser Ser Trp Lys Gln Xaa Glu Lys Gln Asn Ser Ser Asp 
            660                 665                 670         


Leu Ser Ala Lys Pro Lys Phe Ser Lys Pro Phe Asn Pro Leu Gln Asn 
        675                 680                 685             


Lys Gly His Tyr Ala Phe Ser His Xaa Gly Asp Ser Ser Asp Asn Ile 
    690                 695                 700                 


Met Leu Xaa Gln Phe Val Ser Asn Glu 
705                 710             


<210> 1665
<211> 218
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<400> 1665
Met Lys Val Gly Val Leu Trp Leu Ile Ser Phe Phe Xaa Phe Xaa Asp 
1               5                   10                  15      


Gly His Gly Gly Phe Leu Gly Lys Asn Asp Gly Ile Lys Xaa Lys Lys 
            20                  25                  30          


Glu Leu Ile Val Asn Lys Lys Lys His Leu Gly Pro Val Glu Glu Tyr 
        35                  40                  45              


Gln Leu Leu Leu Gln Val Xaa Tyr Arg Asp Ser Lys Glu Lys Arg Asp 
    50                  55                  60                  


Leu Arg Asn Phe Leu Lys Leu Leu Lys Pro Pro Leu Leu Trp Ser His 
65                  70                  75                  80  


Gly Leu Ile Arg Ile Ile Arg Ala Lys Ala Xaa Xaa Asp Cys Asn Ser 
                85                  90                  95      


Leu Asn Gly Val Leu Gln Cys Xaa Cys Glu Asp Ser Tyr Xaa Trp Phe 
            100                 105                 110         


Pro Pro Ser Cys Leu Asp Pro Gln Asn Cys Tyr Leu His Xaa Ala Gly 
        115                 120                 125             


Ala Leu Pro Ser Cys Glu Cys His Leu Asn Asn Leu Ser Gln Ser Val 
    130                 135                 140                 


Asn Phe Cys Glu Arg Xaa Lys Ile Trp Gly Xaa Phe Lys Ile Asn Glu 
145                 150                 155                 160 


Arg Phe Xaa Asn Asp Leu Leu Asn Ser Ser Ser Ala Ile Tyr Ser Lys 
                165                 170                 175     


Tyr Ala Asn Gly Ile Glu Ile Gln Leu Lys Lys Ala Tyr Glu Arg Ile 
            180                 185                 190         


Gln Gly Phe Glu Ser Val Gln Val Xaa Gln Phe Arg Met Ser Leu Leu 
        195                 200                 205             


Ser Pro Lys Leu Glu Cys Asn Gly Xaa Ile 
    210                 215             


<210> 1666
<211> 910
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<400> 1666
Met Lys Val Gly Val Leu Trp Leu Ile Ser Phe Phe Xaa Phe Xaa Asp 
1               5                   10                  15      


Gly His Gly Gly Phe Leu Gly Lys Asn Asp Gly Ile Lys Xaa Lys Lys 
            20                  25                  30          


Glu Leu Ile Val Asn Lys Lys Lys His Leu Gly Pro Val Glu Glu Tyr 
        35                  40                  45              


Gln Leu Leu Leu Gln Val Xaa Tyr Arg Asp Ser Lys Glu Lys Arg Asp 
    50                  55                  60                  


Leu Arg Asn Phe Leu Lys Leu Leu Lys Pro Pro Leu Leu Trp Ser His 
65                  70                  75                  80  


Gly Leu Ile Arg Ile Ile Arg Ala Lys Ala Xaa Xaa Asp Cys Asn Ser 
                85                  90                  95      


Leu Asn Gly Val Leu Gln Cys Xaa Cys Glu Asp Ser Tyr Xaa Trp Phe 
            100                 105                 110         


Pro Pro Ser Cys Leu Asp Pro Gln Asn Cys Tyr Leu His Xaa Ala Gly 
        115                 120                 125             


Ala Leu Pro Ser Cys Glu Cys His Leu Asn Asn Leu Ser Gln Ser Val 
    130                 135                 140                 


Asn Phe Cys Glu Arg Xaa Lys Ile Trp Gly Xaa Phe Lys Ile Asn Glu 
145                 150                 155                 160 


Arg Phe Xaa Asn Asp Leu Leu Asn Ser Ser Ser Ala Ile Tyr Ser Lys 
                165                 170                 175     


Tyr Ala Asn Gly Ile Glu Ile Gln Leu Lys Lys Ala Tyr Glu Arg Ile 
            180                 185                 190         


Gln Gly Phe Glu Ser Val Gln Val Xaa Gln Phe Arg Asn Gly Ser Ile 
        195                 200                 205             


Val Ala Gly Tyr Glu Val Val Gly Ser Ser Ser Ala Ser Glu Leu Leu 
    210                 215                 220                 


Ser Ala Ile Glu His Val Ala Glu Lys Ala Lys Xaa Ala Leu His Lys 
225                 230                 235                 240 


Leu Phe Pro Leu Glu Asp Gly Ser Phe Arg Val Phe Gly Lys Ala Gln 
                245                 250                 255     


Cys Asn Asp Ile Val Phe Gly Phe Gly Ser Lys Asp Asp Glu Tyr Xaa 
            260                 265                 270         


Leu Pro Cys Ser Ser Gly Tyr Arg Gly Asn Ile Xaa Ala Lys Cys Glu 
        275                 280                 285             


Ser Ser Gly Trp Gln Val Ile Arg Glu Xaa Cys Val Leu Ser Leu Leu 
    290                 295                 300                 


Glu Glu Leu Asn Lys Asn Phe Ser Met Ile Val Gly Asn Ala Xaa Glu 
305                 310                 315                 320 


Ala Ala Val Ser Ser Phe Val Gln Asn Leu Ser Val Ile Ile Arg Gln 
                325                 330                 335     


Asn Pro Ser Xaa Xaa Val Gly Asn Leu Ala Ser Val Val Ser Ile Leu 
            340                 345                 350         


Ser Asn Ile Ser Ser Leu Ser Leu Ala Ser His Phe Arg Val Ser Asn 
        355                 360                 365             


Ser Xaa Met Glu Asp Val Ile Ser Ile Ala Asp Asn Ile Leu Asn Ser 
    370                 375                 380                 


Ala Ser Val Xaa Asn Trp Xaa Val Leu Leu Arg Glu Glu Lys Tyr Ala 
385                 390                 395                 400 


Ser Ser Arg Leu Leu Glu Xaa Leu Glu Asn Ile Ser Xaa Leu Val Pro 
                405                 410                 415     


Pro Xaa Ala Leu Pro Leu Asn Phe Ser Arg Lys Phe Ile Asp Trp Lys 
            420                 425                 430         


Gly Ile Pro Val Asn Lys Ser Gln Leu Lys Arg Gly Tyr Ser Tyr Gln 
        435                 440                 445             


Ile Lys Met Cys Pro Gln Asn Xaa Ser Ile Pro Ile Arg Gly Arg Val 
    450                 455                 460                 


Leu Ile Gly Ser Asp Gln Phe Gln Arg Ser Leu Pro Glu Xaa Ile Ile 
465                 470                 475                 480 


Ser Met Ala Ser Leu Xaa Leu Gly Asn Ile Leu Pro Val Ser Lys Asn 
                485                 490                 495     


Gly Asn Ala Gln Val Asn Gly Pro Val Ile Ser Xaa Val Ile Gln Asn 
            500                 505                 510         


Tyr Ser Ile Asn Glu Val Phe Leu Phe Phe Ser Lys Ile Glu Ser Asn 
        515                 520                 525             


Leu Ser Gln Pro His Cys Val Phe Trp Asp Phe Ser His Leu Gln Trp 
    530                 535                 540                 


Asn Asp Ala Gly Cys His Leu Val Asn Glu Xaa Gln Asp Ile Val Xaa 
545                 550                 555                 560 


Cys Gln Cys Xaa His Leu Xaa Ser Phe Ser Ile Leu Met Ser Pro Phe 
                565                 570                 575     


Val Pro Ser Xaa Ile Phe Pro Val Val Lys Trp Ile Xaa Tyr Val Gly 
            580                 585                 590         


Leu Gly Ile Ser Ile Gly Ser Leu Ile Leu Cys Leu Ile Ile Glu Ala 
        595                 600                 605             


Leu Phe Trp Lys Gln Ile Lys Lys Ser Gln Xaa Ser His Xaa Arg Arg 
    610                 615                 620                 


Ile Cys Met Val Asn Ile Ala Leu Ser Leu Leu Ile Ala Asp Val Trp 
625                 630                 635                 640 


Phe Ile Val Gly Ala Xaa Val Asp Xaa Xaa Val Asn Pro Ser Gly Val 
                645                 650                 655     


Cys Xaa Ala Ala Val Phe Phe Xaa His Phe Phe Tyr Leu Ser Leu Phe 
            660                 665                 670         


Phe Trp Met Leu Met Leu Gly Ile Leu Leu Ala Tyr Arg Ile Ile Leu 
        675                 680                 685             


Val Phe His His Met Ala Gln His Leu Met Met Ala Val Gly Phe Cys 
    690                 695                 700                 


Leu Gly Tyr Gly Cys Pro Leu Ile Ile Ser Val Ile Xaa Ile Ala Val 
705                 710                 715                 720 


Xaa Gln Pro Ser Asn Xaa Tyr Lys Arg Lys Asp Val Cys Trp Leu Asn 
                725                 730                 735     


Trp Ser Asn Gly Ser Lys Pro Leu Leu Ala Phe Val Val Pro Ala Leu 
            740                 745                 750         


Ala Ile Val Ala Val Asn Phe Val Val Val Leu Leu Val Leu Xaa Lys 
        755                 760                 765             


Leu Trp Arg Pro Xaa Val Gly Glu Arg Leu Ser Arg Asp Asp Lys Ala 
    770                 775                 780                 


Xaa Ile Ile Arg Val Gly Lys Ser Leu Leu Ile Leu Xaa Pro Leu Leu 
785                 790                 795                 800 


Gly Leu Xaa Trp Gly Phe Gly Ile Gly Xaa Ile Val Asp Ser Gln Asn 
                805                 810                 815     


Leu Ala Trp His Val Ile Phe Ala Leu Leu Asn Ala Phe Gln Gly Phe 
            820                 825                 830         


Phe Ile Leu Cys Phe Gly Ile Leu Leu Asp Ser Lys Leu Arg Gln Leu 
        835                 840                 845             


Leu Phe Asn Lys Leu Ser Ala Leu Ser Ser Trp Lys Gln Xaa Glu Lys 
    850                 855                 860                 


Gln Asn Ser Ser Asp Leu Ser Ala Lys Pro Lys Phe Ser Lys Pro Phe 
865                 870                 875                 880 


Asn Pro Leu Gln Asn Lys Gly His Tyr Ala Phe Ser His Xaa Gly Asp 
                885                 890                 895     


Ser Ser Asp Asn Ile Met Leu Xaa Gln Phe Val Ser Asn Glu 
            900                 905                 910 


<210> 1667
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 1667
Xaa Trp Ser His Gly Leu Ile Arg Ile Ile Arg Ala Lys Ala Xaa Xaa 
1               5                   10                  15      


Asp Cys Asn Ser Leu Asn Gly Val Leu Gln Cys Xaa Cys Glu Asp Ser 
            20                  25                  30          


Tyr Xaa Trp Phe Pro Pro Ser Cys Leu Asp Pro Gln Asn Cys Tyr Leu 
        35                  40                  45              


His Xaa Ala Gly Ala Leu Pro Ser Cys Glu Cys His Leu Asn Asn Leu 
    50                  55                  60                  


Ser Gln Ser Val Asn Phe Cys Glu Arg Xaa Lys Ile Trp Gly Xaa Phe 
65                  70                  75                  80  


Lys Ile Asn Glu Arg Phe Xaa Asn Asp Leu Leu Asn Ser Ser Ser Ala 
                85                  90                  95      


Ile Tyr Ser Lys Tyr Ala Asn Gly Ile Glu Ile Gln Leu Lys Lys Ala 
            100                 105                 110         


Tyr Glu Arg Ile Gln Gly Phe Glu Ser Val Gln Val Xaa Gln Phe Arg 
        115                 120                 125             


Xaa Val Ile His Leu Trp Asn Leu Val 
    130                 135         


<210> 1668
<211> 708
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<400> 1668
Met Gly Leu Xaa Ala Tyr Gly Asn Arg Arg Val Gln Pro Gly Glu Leu 
1               5                   10                  15      


Pro Phe Gly Ala Asn Leu Xaa Leu Ile His Xaa Arg Ala Gln Pro Val 
            20                  25                  30          


Ile Cys Ser Lys Leu Leu Leu Xaa Lys Arg Val Ser Pro Ile Ser Phe 
        35                  40                  45              


Phe Leu Ser Lys Phe Gln Asn Ser Trp Gly Glu Asp Gly Trp Val Gln 
    50                  55                  60                  


Leu Asp Gln Leu Pro Ser Pro Asn Ala Val Ser Ser Asp Gln Val His 
65                  70                  75                  80  


Cys Ser Ala Gly Cys Xaa His Arg Lys Cys Gly Trp Ala Ala Ser Lys 
                85                  90                  95      


Ser Lys Glu Lys Val Pro Ala Arg Pro His Gly Val Cys Asp Gly Val 
            100                 105                 110         


Cys Xaa Asp Tyr Ser Gln Cys Xaa Gln Pro Cys Pro Pro Asp Xaa Gln 
        115                 120                 125             


Gly Asn Met Gly Phe Ser Cys Arg Gln Lys Xaa Trp His Lys Ile Xaa 
    130                 135                 140                 


Asp Xaa Cys Gln Xaa Leu Asn Ala Leu Asn Ile Phe Glu Glu Asp Ser 
145                 150                 155                 160 


Arg Leu Val Gln Pro Phe Glu Asp Asn Ile Lys Ile Ser Val Tyr Xaa 
                165                 170                 175     


Gly Lys Ser Glu Xaa Ile Xaa Asp Met Leu Leu Gln Lys Cys Pro Xaa 
            180                 185                 190         


Asp Leu Ser Cys Val Ile Arg Asn Ile Gln Gln Ser Pro Trp Ile Pro 
        195                 200                 205             


Gly Asn Ile Ala Val Ile Val Gln Leu Leu His Asn Ile Ser Xaa Ala 
    210                 215                 220                 


Ile Trp Xaa Gly Val Asp Glu Ala Lys Met Gln Ser Tyr Ser Xaa Ile 
225                 230                 235                 240 


Ala Asn His Ile Leu Asn Ser Lys Ser Ile Ser Asn Trp Xaa Phe Ile 
                245                 250                 255     


Pro Asp Arg Asn Ser Ser Tyr Ile Leu Leu His Ser Val Asn Ser Phe 
            260                 265                 270         


Ala Arg Arg Leu Phe Ile Asp Lys His Pro Val Asp Ile Ser Asp Val 
        275                 280                 285             


Phe Ile His Xaa Met Gly Xaa Xaa Ile Ser Gly Asp Asn Ile Gly Lys 
    290                 295                 300                 


Asn Phe Xaa Phe Ser Met Arg Ile Asn Asp Xaa Ser Asn Glu Val Xaa 
305                 310                 315                 320 


Gly Arg Val Leu Ile Ser Arg Asp Glu Leu Arg Lys Val Pro Ser Pro 
                325                 330                 335     


Ser Gln Val Ile Ser Ile Ala Phe Pro Xaa Ile Gly Ala Ile Leu Glu 
            340                 345                 350         


Ala Ser Leu Leu Glu Asn Val Xaa Val Asn Gly Leu Val Leu Ser Ala 
        355                 360                 365             


Ile Leu Pro Lys Glu Leu Lys Arg Ile Ser Leu Ile Phe Glu Lys Ile 
    370                 375                 380                 


Ser Lys Ser Glu Glu Arg Arg Xaa Gln Cys Val Gly Trp His Ser Val 
385                 390                 395                 400 


Glu Asn Arg Trp Asp Gln Gln Ala Cys Lys Met Ile Gln Glu Asn Ser 
                405                 410                 415     


Gln Gln Ala Val Cys Lys Cys Arg Pro Ser Lys Leu Phe Xaa Ser Phe 
            420                 425                 430         


Ser Ile Leu Met Ser Pro His Ile Leu Glu Ser Leu Ile Leu Xaa Tyr 
        435                 440                 445             


Ile Xaa Tyr Val Gly Leu Gly Ile Ser Ile Cys Ser Leu Ile Leu Cys 
    450                 455                 460                 


Leu Ser Ile Glu Val Leu Val Trp Ser Gln Val Xaa Lys Xaa Glu Ile 
465                 470                 475                 480 


Xaa Tyr Leu Arg His Val Cys Ile Val Asn Ile Ala Ala Xaa Leu Leu 
                485                 490                 495     


Met Ala Asp Val Trp Phe Ile Val Ala Ser Phe Leu Ser Gly Pro Ile 
            500                 505                 510         


Xaa His His Lys Gly Cys Val Ala Ala Xaa Phe Phe Val His Phe Phe 
        515                 520                 525             


Tyr Leu Ser Val Phe Phe Trp Met Leu Ala Lys Ala Leu Leu Ile Leu 
    530                 535                 540                 


Tyr Gly Ile Met Ile Val Phe His Xaa Leu Pro Lys Ser Val Leu Val 
545                 550                 555                 560 


Ala Ser Leu Phe Ser Val Gly Tyr Gly Cys Pro Leu Ala Ile Ala Ala 
                565                 570                 575     


Ile Xaa Val Ala Ala Xaa Glu Pro Gly Lys Gly Tyr Leu Arg Pro Glu 
            580                 585                 590         


Ile Cys Trp Leu Asn Trp Asp Met Xaa Lys Ala Leu Leu Ala Phe Val 
        595                 600                 605             


Ile Pro Ala Leu Ala Ile Val Val Val Asn Leu Ile Xaa Val Xaa Leu 
    610                 615                 620                 


Val Ile Val Lys Xaa Gln Arg Ala Ala Ile Gly Asn Ser Met Phe Gln 
625                 630                 635                 640 


Glu Val Arg Ala Ile Val Arg Ile Ser Lys Asn Ile Ala Ile Leu Xaa 
                645                 650                 655     


Pro Leu Leu Gly Leu Xaa Trp Gly Phe Gly Val Ala Xaa Val Ile Asp 
            660                 665                 670         


Asp Arg Ser Leu Ala Phe His Ile Ile Phe Ser Leu Leu Asn Ala Phe 
        675                 680                 685             


Gln Val Ser Pro Asp Ala Ser Asp Gln Val Gln Ser Glu Arg Ile His 
    690                 695                 700                 


Glu Asp Val Leu 
705             


<210> 1669
<211> 640
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<400> 1669
Met Xaa His Ile Leu Leu Leu Tyr Tyr Leu Val Phe Leu Leu Pro Xaa 
1               5                   10                  15      


Glu Ser Cys Arg Xaa Leu Tyr Gln Ala Ala Ser Lys Ser Lys Glu Lys 
            20                  25                  30          


Val Pro Ala Arg Pro His Gly Val Cys Asp Gly Val Cys Xaa Asp Tyr 
        35                  40                  45              


Ser Gln Cys Xaa Gln Pro Cys Pro Pro Asp Xaa Gln Gly Asn Met Gly 
    50                  55                  60                  


Phe Ser Cys Arg Gln Lys Xaa Trp His Lys Ile Xaa Asp Xaa Cys Gln 
65                  70                  75                  80  


Xaa Leu Asn Ala Leu Asn Ile Phe Glu Glu Asp Ser Arg Leu Val Gln 
                85                  90                  95      


Pro Phe Glu Asp Asn Ile Lys Ile Ser Val Tyr Xaa Gly Lys Ser Glu 
            100                 105                 110         


Xaa Ile Xaa Asp Met Leu Leu Gln Lys Cys Pro Xaa Asp Leu Ser Cys 
        115                 120                 125             


Val Ile Arg Asn Ile Gln Gln Ser Pro Trp Ile Pro Gly Asn Ile Ala 
    130                 135                 140                 


Val Ile Val Gln Leu Leu His Asn Ile Ser Xaa Ala Ile Trp Xaa Gly 
145                 150                 155                 160 


Val Asp Glu Ala Lys Met Gln Ser Tyr Ser Xaa Ile Ala Asn His Ile 
                165                 170                 175     


Leu Asn Ser Lys Ser Ile Ser Asn Trp Xaa Phe Ile Pro Asp Arg Asn 
            180                 185                 190         


Ser Ser Tyr Ile Leu Leu His Ser Val Asn Ser Phe Ala Arg Arg Leu 
        195                 200                 205             


Phe Ile Asp Lys His Pro Val Asp Ile Ser Asp Val Phe Ile His Xaa 
    210                 215                 220                 


Met Gly Xaa Xaa Ile Ser Gly Asp Asn Ile Gly Lys Asn Phe Xaa Phe 
225                 230                 235                 240 


Ser Met Arg Ile Asn Asp Xaa Ser Asn Glu Val Xaa Gly Arg Val Leu 
                245                 250                 255     


Ile Ser Arg Asp Glu Leu Arg Lys Val Pro Ser Pro Ser Gln Val Ile 
            260                 265                 270         


Ser Ile Ala Phe Pro Xaa Ile Gly Ala Ile Leu Glu Ala Ser Leu Leu 
        275                 280                 285             


Glu Asn Val Xaa Val Asn Gly Leu Val Leu Ser Ala Ile Leu Pro Lys 
    290                 295                 300                 


Glu Leu Lys Arg Ile Ser Leu Ile Phe Glu Lys Ile Ser Lys Ser Glu 
305                 310                 315                 320 


Glu Arg Arg Xaa Gln Cys Val Gly Trp His Ser Val Glu Asn Arg Trp 
                325                 330                 335     


Asp Gln Gln Ala Cys Lys Met Ile Gln Glu Asn Ser Gln Gln Ala Val 
            340                 345                 350         


Cys Lys Cys Arg Pro Ser Lys Leu Phe Xaa Ser Phe Ser Ile Leu Met 
        355                 360                 365             


Ser Pro His Ile Leu Glu Ser Leu Ile Leu Xaa Tyr Ile Xaa Tyr Val 
    370                 375                 380                 


Gly Leu Gly Ile Ser Ile Cys Ser Leu Ile Leu Cys Leu Ser Ile Glu 
385                 390                 395                 400 


Val Leu Val Trp Ser Gln Val Xaa Lys Xaa Glu Ile Xaa Tyr Leu Arg 
                405                 410                 415     


His Val Cys Ile Val Asn Ile Ala Ala Xaa Leu Leu Met Ala Asp Val 
            420                 425                 430         


Trp Phe Ile Val Ala Ser Phe Leu Ser Gly Pro Ile Xaa His His Lys 
        435                 440                 445             


Gly Cys Val Ala Ala Xaa Phe Phe Val His Phe Phe Tyr Leu Ser Val 
    450                 455                 460                 


Phe Phe Trp Met Leu Ala Lys Ala Leu Leu Ile Leu Tyr Gly Ile Met 
465                 470                 475                 480 


Ile Val Phe His Xaa Leu Pro Lys Ser Val Leu Val Ala Ser Leu Phe 
                485                 490                 495     


Ser Val Gly Tyr Gly Cys Pro Leu Ala Ile Ala Ala Ile Xaa Val Ala 
            500                 505                 510         


Ala Xaa Glu Pro Gly Lys Gly Tyr Leu Arg Pro Glu Ile Cys Trp Leu 
        515                 520                 525             


Asn Trp Asp Met Xaa Lys Ala Leu Leu Ala Phe Val Ile Pro Ala Leu 
    530                 535                 540                 


Ala Ile Val Val Val Asn Leu Ile Xaa Val Xaa Leu Val Ile Val Lys 
545                 550                 555                 560 


Xaa Gln Arg Ala Ala Ile Gly Asn Ser Met Phe Gln Glu Val Arg Ala 
                565                 570                 575     


Ile Val Arg Ile Ser Lys Asn Ile Ala Ile Leu Xaa Pro Leu Leu Gly 
            580                 585                 590         


Leu Xaa Trp Gly Phe Gly Val Ala Xaa Val Ile Asp Asp Arg Ser Leu 
        595                 600                 605             


Ala Phe His Ile Ile Phe Ser Leu Leu Asn Ala Phe Gln Val Ser Pro 
    610                 615                 620                 


Asp Ala Ser Asp Gln Val Gln Ser Glu Arg Ile His Glu Asp Val Leu 
625                 630                 635                 640 


<210> 1670
<211> 642
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<400> 1670
Met Xaa His Ile Leu Leu Leu Tyr Tyr Leu Val Phe Leu Leu Pro Xaa 
1               5                   10                  15      


Glu Ser Cys Arg Xaa Leu Tyr Gln Ala Ala Ser Lys Ser Lys Glu Lys 
            20                  25                  30          


Val Pro Ala Arg Pro His Gly Val Cys Asp Gly Val Cys Xaa Asp Tyr 
        35                  40                  45              


Ser Gln Cys Xaa Gln Pro Cys Pro Pro Asp Xaa Gln Gly Asn Met Gly 
    50                  55                  60                  


Phe Ser Cys Arg Gln Lys Xaa Trp His Lys Ile Xaa Asp Xaa Cys Gln 
65                  70                  75                  80  


Xaa Leu Asn Ala Leu Asn Ile Phe Glu Glu Asp Ser Arg Leu Val Gln 
                85                  90                  95      


Pro Phe Glu Asp Asn Ile Lys Ile Ser Val Tyr Xaa Gly Lys Ser Glu 
            100                 105                 110         


Xaa Ile Xaa Asp Met Leu Leu Gln Lys Cys Pro Xaa Asp Leu Ser Cys 
        115                 120                 125             


Val Ile Arg Asn Ile Gln Gln Ser Pro Trp Ile Pro Gly Asn Ile Ala 
    130                 135                 140                 


Val Ile Val Gln Leu Leu His Asn Ile Ser Xaa Ala Ile Trp Xaa Gly 
145                 150                 155                 160 


Val Asp Glu Ala Lys Met Gln Ser Tyr Ser Xaa Ile Ala Asn His Ile 
                165                 170                 175     


Leu Asn Ser Lys Ser Ile Ser Asn Trp Xaa Phe Ile Pro Asp Arg Asn 
            180                 185                 190         


Ser Ser Tyr Ile Leu Leu His Ser Val Asn Ser Phe Ala Arg Arg Leu 
        195                 200                 205             


Phe Ile Asp Lys His Pro Val Asp Ile Ser Asp Val Phe Ile His Xaa 
    210                 215                 220                 


Met Gly Xaa Xaa Ile Ser Gly Asp Asn Ile Gly Lys Asn Phe Xaa Phe 
225                 230                 235                 240 


Ser Met Arg Ile Asn Asp Xaa Ser Asn Glu Val Xaa Gly Arg Val Leu 
                245                 250                 255     


Ile Ser Arg Asp Glu Leu Arg Lys Val Pro Ser Pro Ser Gln Val Ile 
            260                 265                 270         


Ser Ile Ala Phe Pro Xaa Ile Gly Ala Ile Leu Glu Ala Ser Leu Leu 
        275                 280                 285             


Glu Asn Val Xaa Val Asn Gly Leu Val Leu Ser Ala Ile Leu Pro Lys 
    290                 295                 300                 


Glu Leu Lys Arg Ile Ser Leu Ile Phe Glu Lys Ile Ser Lys Ser Glu 
305                 310                 315                 320 


Glu Arg Arg Xaa Gln Cys Val Gly Trp His Ser Val Glu Asn Arg Trp 
                325                 330                 335     


Asp Gln Gln Ala Cys Lys Met Ile Gln Glu Asn Ser Gln Gln Ala Val 
            340                 345                 350         


Cys Lys Cys Arg Pro Ser Lys Leu Phe Xaa Ser Phe Ser Ile Leu Met 
        355                 360                 365             


Ser Pro His Ile Leu Glu Ser Leu Ile Leu Xaa Tyr Ile Xaa Tyr Val 
    370                 375                 380                 


Gly Leu Gly Ile Ser Ile Cys Ser Leu Ile Leu Cys Leu Ser Ile Glu 
385                 390                 395                 400 


Val Leu Val Trp Ser Gln Val Xaa Lys Xaa Glu Ile Xaa Tyr Leu Arg 
                405                 410                 415     


His Val Cys Ile Val Asn Ile Ala Ala Xaa Leu Leu Met Ala Asp Val 
            420                 425                 430         


Trp Phe Ile Val Ala Ser Phe Leu Ser Gly Pro Ile Xaa His His Lys 
        435                 440                 445             


Gly Cys Val Ala Ala Xaa Phe Phe Val His Phe Phe Tyr Leu Ser Val 
    450                 455                 460                 


Phe Phe Trp Met Leu Ala Lys Ala Leu Leu Ile Leu Tyr Gly Ile Met 
465                 470                 475                 480 


Ile Val Phe His Xaa Leu Pro Lys Ser Val Leu Val Ala Ser Leu Phe 
                485                 490                 495     


Ser Val Gly Tyr Gly Cys Pro Leu Ala Ile Ala Ala Ile Xaa Val Ala 
            500                 505                 510         


Ala Xaa Glu Pro Gly Lys Gly Tyr Leu Arg Pro Glu Ile Cys Trp Leu 
        515                 520                 525             


Asn Trp Asp Met Xaa Lys Ala Leu Leu Ala Phe Val Ile Pro Ala Leu 
    530                 535                 540                 


Ala Ile Val Val Val Asn Leu Ile Xaa Val Xaa Leu Val Ile Val Lys 
545                 550                 555                 560 


Xaa Gln Arg Ala Ala Ile Gly Asn Ser Met Phe Gln Glu Val Arg Ala 
                565                 570                 575     


Ile Val Arg Ile Ser Lys Asn Ile Ala Ile Leu Xaa Pro Leu Leu Gly 
            580                 585                 590         


Leu Xaa Trp Gly Phe Gly Val Ala Xaa Val Ile Asp Asp Arg Ser Leu 
        595                 600                 605             


Ala Phe His Ile Ile Phe Ser Leu Leu Asn Ala Phe Gln Gly Phe Phe 
    610                 615                 620                 


Ile Leu Val Phe Gly Xaa Ile Leu Asp Pro Lys Ile Arg Glu Ala Leu 
625                 630                 635                 640 


Lys Gly 
        


<210> 1671
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<400> 1671
Met Xaa Xaa Arg Lys Leu Ser Ala His Ser Ala Ala Xaa Pro Gly Tyr 
1               5                   10                  15      


Lys Ala Val Xaa His Lys His His Xaa Gly Trp Ala Arg Met Ala Lys 
            20                  25                  30          


Xaa Gly Leu Pro Glu Lys Gly Gln Ser Gln Ala Gly Gly Glu Ser Gly 
        35                  40                  45              


Ser Gly Gln Leu Leu Asp Gln Glu Asn Gly Ala Gly Glu Ser Ala Leu 
    50                  55                  60                  


Val Ser Val Tyr Val His Leu Asp Phe Pro Asp Lys Xaa Trp Pro Pro 
65                  70                  75                  80  


Glu Leu Ser Arg Xaa Leu Xaa Leu 
                85              


<210> 1672
<211> 873
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<400> 1672
Met Xaa Xaa Arg Lys Leu Ser Ala His Ser Ala Ala Xaa Pro Gly Tyr 
1               5                   10                  15      


Lys Ala Val Xaa His Lys His His Xaa Gly Trp Ala Arg Met Ala Lys 
            20                  25                  30          


Xaa Gly Leu Pro Glu Lys Gly Gln Ser Gln Ala Gly Gly Glu Ser Gly 
        35                  40                  45              


Ser Gly Gln Leu Leu Asp Gln Glu Asn Gly Ala Gly Glu Ser Ala Leu 
    50                  55                  60                  


Val Ser Val Tyr Val His Leu Asp Phe Pro Asp Lys Xaa Trp Pro Pro 
65                  70                  75                  80  


Glu Leu Ser Arg Xaa Leu Xaa Leu Pro Ala Ala Ser Ala Ser Ser Ser 
                85                  90                  95      


Pro Arg Pro Leu Leu Xaa Gly Leu Arg Leu Xaa Xaa Gly Glu Tyr Met 
            100                 105                 110         


Ser Cys Phe Glu Ala Gln Gly Phe Lys Trp Asn Leu Tyr Glu Val Val 
        115                 120                 125             


Arg Val Pro Leu Lys Ala Xaa Asp Val Ala Arg Leu Pro Tyr Gln Leu 
    130                 135                 140                 


Ser Ile Ser Cys Ala Xaa Ser Pro Gly Phe Gln Leu Ser Cys Cys Ile 
145                 150                 155                 160 


Pro Ser Xaa Asn Leu Ala Tyr Xaa Ala Ala Trp Ser Pro Gly Glu Gly 
                165                 170                 175     


Ser Lys Ala Ser Ser Phe Asn Glu Ser Gly Ser Gln Cys Phe Val Leu 
            180                 185                 190         


Ala Val Gln Arg Cys Pro Met Ala Asp Xaa Xaa Tyr Ala Cys Asp Leu 
        195                 200                 205             


Gln Ser Leu Gly Leu Ala Pro Leu Arg Val Pro Ile Ser Ile Xaa Ile 
    210                 215                 220                 


Ile Gln Asp Gly Asp Ile Xaa Cys Pro Glu Asp Ala Ser Val Leu Xaa 
225                 230                 235                 240 


Trp Asn Val Xaa Lys Ala Gly His Val Ala Gln Ala Pro Cys Pro Glu 
                245                 250                 255     


Ser Lys Arg Gly Ile Val Arg Arg Leu Cys Gly Ala Asp Gly Val Trp 
            260                 265                 270         


Gly Pro Val His Ser Ser Cys Xaa Asp Ala Arg Leu Leu Ala Leu Phe 
        275                 280                 285             


Xaa Arg Xaa Lys Leu Leu Gln Ala Gly Gln Gly Ser Pro Ala Glu Glu 
    290                 295                 300                 


Val Pro Gln Ile Leu Ala Gln Leu Pro Gly Gln Ala Ala Glu Ala Ser 
305                 310                 315                 320 


Ser Pro Ser Asp Leu Leu Xaa Leu Leu Ser Xaa Met Lys Tyr Val Ala 
                325                 330                 335     


Lys Val Val Ala Glu Ala Arg Ile Gln Leu Asp Arg Arg Ala Leu Lys 
            340                 345                 350         


Asn Leu Leu Ile Ala Xaa Asp Lys Val Leu Asp Met Asp Xaa Arg Ser 
        355                 360                 365             


Leu Trp Xaa Leu Ala Gln Ala Arg Lys Pro Trp Ala Gly Ser Xaa Leu 
    370                 375                 380                 


Leu Leu Ala Val Glu Xaa Leu Ala Cys Ser Leu Cys Pro Gln Asp His 
385                 390                 395                 400 


Pro Phe Ala Phe Ser Leu Pro Asn Val Leu Leu Gln Ser Gln Leu Phe 
                405                 410                 415     


Gly Pro Xaa Phe Pro Ala Asp Tyr Ser Ile Ser Phe Pro Xaa Arg Pro 
            420                 425                 430         


Pro Leu Gln Ala Gln Ile Pro Arg His Ser Leu Ala Pro Leu Val Arg 
        435                 440                 445             


Asn Gly Xaa Glu Ile Ser Ile Xaa Ser Leu Val Leu Arg Lys Leu Asp 
    450                 455                 460                 


His Leu Leu Pro Ser Asn Tyr Gly Gln Gly Leu Gly Asp Ser Leu Tyr 
465                 470                 475                 480 


Ala Xaa Pro Gly Leu Val Leu Val Ile Ser Ile Met Ala Gly Asp Arg 
                485                 490                 495     


Ala Phe Ser Gln Gly Glu Val Ile Met Asp Phe Gly Asn Xaa Asp Gly 
            500                 505                 510         


Ser Pro His Cys Val Phe Trp Asp His Ser Leu Phe Gln Gly Arg Gly 
        515                 520                 525             


Gly Trp Ser Lys Glu Gly Cys Gln Ala Gln Val Ala Ser Ala Ser Pro 
    530                 535                 540                 


Xaa Ala Gln Cys Leu Cys Gln His Leu Xaa Ala Phe Ser Val Leu Met 
545                 550                 555                 560 


Ser Pro His Xaa Val Pro Glu Glu Pro Ala Leu Ala Leu Leu Xaa Gln 
                565                 570                 575     


Val Gly Leu Gly Ala Ser Ile Leu Ala Leu Leu Val Cys Leu Gly Val 
            580                 585                 590         


Tyr Trp Leu Val Trp Arg Val Val Val Arg Asn Lys Ile Ser Tyr Phe 
        595                 600                 605             


Arg His Ala Ala Leu Leu Asn Met Val Phe Cys Leu Leu Ala Ala Asp 
    610                 615                 620                 


Xaa Cys Phe Leu Gly Ala Pro Phe Leu Ser Pro Gly Pro Arg Ser Pro 
625                 630                 635                 640 


Leu Cys Leu Ala Ala Ala Phe Leu Cys His Phe Leu Tyr Leu Ala Xaa 
                645                 650                 655     


Phe Phe Trp Met Leu Ala Gln Ala Leu Val Leu Ala His Gln Leu Leu 
            660                 665                 670         


Phe Val Phe His Gln Leu Ala Lys His Arg Val Leu Pro Leu Met Val 
        675                 680                 685             


Leu Leu Gly Tyr Leu Cys Pro Leu Gly Leu Ala Gly Val Xaa Leu Gly 
    690                 695                 700                 


Leu Tyr Leu Pro Gln Gly Gln Tyr Leu Arg Glu Gly Glu Cys Trp Leu 
705                 710                 715                 720 


Asp Gly Lys Gly Gly Ala Leu Tyr Xaa Phe Val Gly Pro Val Leu Ala 
                725                 730                 735     


Ile Ile Gly Val Asn Gly Leu Val Leu Ala Met Ala Met Leu Lys Leu 
            740                 745                 750         


Leu Arg Pro Ser Leu Ser Glu Gly Pro Pro Ala Glu Lys Arg Gln Ala 
        755                 760                 765             


Leu Leu Gly Val Ile Lys Ala Leu Leu Ile Leu Xaa Pro Ile Phe Gly 
    770                 775                 780                 


Leu Xaa Trp Gly Leu Gly Leu Ala Xaa Leu Leu Glu Glu Val Ser Xaa 
785                 790                 795                 800 


Val Pro His Tyr Ile Phe Xaa Ile Leu Asn Xaa Leu Gln Gly Val Phe 
                805                 810                 815     


Ile Leu Leu Phe Gly Cys Leu Met Asp Arg Lys Ile Gln Glu Ala Leu 
            820                 825                 830         


Arg Lys Arg Phe Cys Arg Ala Gln Ala Pro Ser Ser Xaa Ile Ser Leu 
        835                 840                 845             


Ala Xaa Asn Glu Gly Cys Ile Leu Glu His Ser Lys Gly Gly Ser Asp 
    850                 855                 860                 


Xaa Ala Arg Lys Xaa Asp Ala Ser Glu 
865                 870             


<210> 1673
<211> 120
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<400> 1673
Met Xaa Xaa Arg Lys Leu Ser Ala His Ser Ala Ala Xaa Pro Gly Tyr 
1               5                   10                  15      


Lys Ala Val Xaa His Lys His His Xaa Gly Trp Ala Arg Met Ala Lys 
            20                  25                  30          


Xaa Gly Leu Pro Glu Lys Leu Pro Pro Ser Xaa Ser Gln Ala Leu Ser 
        35                  40                  45              


Ala Leu Cys Trp Leu Phe Ser Ala Ala Arg Trp Leu Xaa Pro Arg Xaa 
    50                  55                  60                  


Leu Val Xaa Cys Arg Ala Trp Ala Trp Leu His Ser Gly Ser Pro Ser 
65                  70                  75                  80  


Pro Ser Pro Ser Ser Arg Met Glu Xaa Ser Pro Ala Leu Arg Xaa Pro 
                85                  90                  95      


Arg Cys Ser Pro Gly Met Ser Pro Arg Leu Ala Xaa Trp His Arg Pro 
            100                 105                 110         


His Val Leu Arg Ala Arg Gly Ala 
        115                 120 


<210> 1674
<211> 997
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<400> 1674
Met Val Cys Ser Ala Ala Pro Leu Leu Leu Leu Ala Xaa Xaa Leu Pro 
1               5                   10                  15      


Leu Leu Gly Ser Pro Val Ala Gln Ala Ser Gln Pro Gly Gln Ser Gln 
            20                  25                  30          


Ala Gly Gly Glu Ser Gly Ser Gly Gln Leu Leu Asp Gln Glu Asn Gly 
        35                  40                  45              


Ala Gly Glu Ser Ala Leu Val Ser Val Tyr Val His Leu Asp Phe Pro 
    50                  55                  60                  


Asp Lys Xaa Trp Pro Pro Glu Leu Ser Arg Xaa Leu Xaa Leu Pro Ala 
65                  70                  75                  80  


Ala Ser Ala Ser Ser Ser Pro Arg Pro Leu Leu Xaa Gly Leu Arg Leu 
                85                  90                  95      


Xaa Xaa Glu Cys Asn Val Asn His Lys Gly Asn Phe Tyr Cys Ala Cys 
            100                 105                 110         


Leu Ser Gly Tyr Gln Trp Asn Xaa Ser Ile Cys Leu His Tyr Pro Pro 
        115                 120                 125             


Cys Gln Ser Leu His Asn His Gln Pro Cys Gly Cys Leu Val Phe Ser 
    130                 135                 140                 


His Pro Glu Pro Gly Tyr Cys Gln Leu Leu Pro Pro Gly Ser Pro Val 
145                 150                 155                 160 


Xaa Cys Leu Pro Ala Val Pro Gly Ile Leu Asn Leu Asn Ser Gln Leu 
                165                 170                 175     


Gln Met Pro Gly Asp Xaa Leu Ser Leu Xaa Leu His Leu Ser Gln Glu 
            180                 185                 190         


Ala Xaa Asn Leu Ser Trp Phe Leu Arg His Pro Gly Ser Pro Ser Pro 
        195                 200                 205             


Ile Leu Leu Gln Pro Gly Xaa Gln Val Ser Val Xaa Ser Ser His Gly 
    210                 215                 220                 


Gln Ala Ala Leu Ser Val Ser Asn Met Ser His His Trp Ala Gly Glu 
225                 230                 235                 240 


Tyr Met Ser Cys Phe Glu Ala Gln Gly Phe Lys Trp Asn Leu Tyr Glu 
                245                 250                 255     


Val Val Arg Val Pro Leu Lys Ala Xaa Asp Val Ala Arg Leu Pro Tyr 
            260                 265                 270         


Gln Leu Ser Ile Ser Cys Ala Xaa Ser Pro Gly Phe Gln Leu Ser Cys 
        275                 280                 285             


Cys Ile Pro Ser Xaa Asn Leu Ala Tyr Xaa Ala Ala Trp Ser Pro Gly 
    290                 295                 300                 


Glu Gly Ser Lys Ala Ser Ser Phe Asn Glu Ser Gly Ser Gln Cys Phe 
305                 310                 315                 320 


Val Leu Ala Val Gln Arg Cys Pro Met Ala Asp Xaa Xaa Tyr Ala Cys 
                325                 330                 335     


Asp Leu Gln Ser Leu Gly Leu Ala Pro Leu Arg Val Pro Ile Ser Ile 
            340                 345                 350         


Xaa Ile Ile Gln Asp Gly Asp Ile Xaa Cys Pro Glu Asp Ala Ser Val 
        355                 360                 365             


Leu Xaa Trp Asn Val Xaa Lys Ala Gly His Val Ala Gln Ala Pro Cys 
    370                 375                 380                 


Pro Glu Ser Lys Arg Gly Ile Val Arg Arg Leu Cys Gly Ala Asp Gly 
385                 390                 395                 400 


Val Trp Gly Pro Val His Ser Ser Cys Xaa Asp Ala Arg Leu Leu Ala 
                405                 410                 415     


Leu Phe Xaa Arg Xaa Lys Leu Leu Gln Ala Gly Gln Gly Ser Pro Ala 
            420                 425                 430         


Glu Glu Val Pro Gln Ile Leu Ala Gln Leu Pro Gly Gln Ala Ala Glu 
        435                 440                 445             


Ala Ser Ser Pro Ser Asp Leu Leu Xaa Leu Leu Ser Xaa Met Lys Tyr 
    450                 455                 460                 


Val Ala Lys Val Val Ala Glu Ala Arg Ile Gln Leu Asp Arg Arg Ala 
465                 470                 475                 480 


Leu Lys Asn Leu Leu Ile Ala Xaa Asp Lys Val Leu Asp Met Asp Xaa 
                485                 490                 495     


Arg Ser Leu Trp Xaa Leu Ala Gln Ala Arg Lys Pro Trp Ala Gly Ser 
            500                 505                 510         


Xaa Leu Leu Leu Ala Val Glu Xaa Leu Ala Cys Ser Leu Cys Pro Gln 
        515                 520                 525             


Asp His Pro Phe Ala Phe Ser Leu Pro Asn Val Leu Leu Gln Ser Gln 
    530                 535                 540                 


Leu Phe Gly Pro Xaa Phe Pro Ala Asp Tyr Ser Ile Ser Phe Pro Xaa 
545                 550                 555                 560 


Arg Pro Pro Leu Gln Ala Gln Ile Pro Arg His Ser Leu Ala Pro Leu 
                565                 570                 575     


Val Arg Asn Gly Xaa Glu Ile Ser Ile Xaa Ser Leu Val Leu Arg Lys 
            580                 585                 590         


Leu Asp His Leu Leu Pro Ser Asn Tyr Gly Gln Gly Leu Gly Asp Ser 
        595                 600                 605             


Leu Tyr Ala Xaa Pro Gly Leu Val Leu Val Ile Ser Ile Met Ala Gly 
    610                 615                 620                 


Asp Arg Ala Phe Ser Gln Gly Glu Val Ile Met Asp Phe Gly Asn Xaa 
625                 630                 635                 640 


Asp Gly Ser Pro His Cys Val Phe Trp Asp His Ser Leu Phe Gln Gly 
                645                 650                 655     


Arg Gly Gly Trp Ser Lys Glu Gly Cys Gln Ala Gln Val Ala Ser Ala 
            660                 665                 670         


Ser Pro Xaa Ala Gln Cys Leu Cys Gln His Leu Xaa Ala Phe Ser Val 
        675                 680                 685             


Leu Met Ser Pro His Xaa Val Pro Glu Glu Pro Ala Leu Ala Leu Leu 
    690                 695                 700                 


Xaa Gln Val Gly Leu Gly Ala Ser Ile Leu Ala Leu Leu Val Cys Leu 
705                 710                 715                 720 


Gly Val Tyr Trp Leu Val Trp Arg Val Val Val Arg Asn Lys Ile Ser 
                725                 730                 735     


Tyr Phe Arg His Ala Ala Leu Leu Asn Met Val Phe Cys Leu Leu Ala 
            740                 745                 750         


Ala Asp Xaa Cys Phe Leu Gly Ala Pro Phe Leu Ser Pro Gly Pro Arg 
        755                 760                 765             


Ser Pro Leu Cys Leu Ala Ala Ala Phe Leu Cys His Phe Leu Tyr Leu 
    770                 775                 780                 


Ala Xaa Phe Phe Trp Met Leu Ala Gln Ala Leu Val Leu Ala His Gln 
785                 790                 795                 800 


Leu Leu Phe Val Phe His Gln Leu Ala Lys His Arg Val Leu Pro Leu 
                805                 810                 815     


Met Val Leu Leu Gly Tyr Leu Cys Pro Leu Gly Leu Ala Gly Val Xaa 
            820                 825                 830         


Leu Gly Leu Tyr Leu Pro Gln Gly Gln Tyr Leu Arg Glu Gly Glu Cys 
        835                 840                 845             


Trp Leu Asp Gly Lys Gly Gly Ala Leu Tyr Xaa Phe Val Gly Pro Val 
    850                 855                 860                 


Leu Ala Ile Ile Gly Val Asn Gly Leu Val Leu Ala Met Ala Met Leu 
865                 870                 875                 880 


Lys Leu Leu Arg Pro Ser Leu Ser Glu Gly Pro Pro Ala Glu Lys Arg 
                885                 890                 895     


Gln Ala Leu Leu Gly Val Ile Lys Ala Leu Leu Ile Leu Xaa Pro Ile 
            900                 905                 910         


Phe Gly Leu Xaa Trp Gly Leu Gly Leu Ala Xaa Leu Leu Glu Glu Val 
        915                 920                 925             


Ser Xaa Val Pro His Tyr Ile Phe Xaa Ile Leu Asn Xaa Leu Gln Gly 
    930                 935                 940                 


Val Phe Ile Leu Leu Phe Gly Cys Leu Met Asp Arg Lys Ile Gln Glu 
945                 950                 955                 960 


Ala Leu Arg Lys Arg Phe Cys Arg Ala Gln Ala Pro Ser Ser Xaa Ile 
                965                 970                 975     


Ser Leu Ala Xaa Asn Glu Gly Cys Ile Leu Glu His Ser Lys Gly Gly 
            980                 985                 990         


Ser Asp Xaa Ala Arg 
        995         


<210> 1675
<211> 1079
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<400> 1675
Met Val Cys Ser Ala Ala Pro Leu Leu Leu Leu Ala Xaa Xaa Leu Pro 
1               5                   10                  15      


Leu Leu Gly Ser Pro Val Ala Gln Ala Ser Gln Pro Val Ser Glu Xaa 
            20                  25                  30          


Gly Val Arg Pro Arg Glu Gly Leu Gln Arg Arg Gln Trp Gly Pro Leu 
        35                  40                  45              


Ile Gly Arg Asp Lys Ala Trp Asn Glu Arg Ile Asp Arg Pro Phe Pro 
    50                  55                  60                  


Ala Cys Pro Ile Pro Leu Ser Ser Ser Phe Gly Arg Trp Pro Lys Gly 
65                  70                  75                  80  


Gln Xaa Met Trp Ala Gln Xaa Ser Xaa Leu Xaa Leu Xaa Glu Glu Glu 
                85                  90                  95      


Leu Gly Gln Ser Gln Ala Gly Gly Glu Ser Gly Ser Gly Gln Leu Leu 
            100                 105                 110         


Asp Gln Glu Asn Gly Ala Gly Glu Ser Ala Leu Val Ser Val Tyr Val 
        115                 120                 125             


His Leu Asp Phe Pro Asp Lys Xaa Trp Pro Pro Glu Leu Ser Arg Xaa 
    130                 135                 140                 


Leu Xaa Leu Pro Ala Ala Ser Ala Ser Ser Ser Pro Arg Pro Leu Leu 
145                 150                 155                 160 


Xaa Gly Leu Arg Leu Xaa Xaa Glu Cys Asn Val Asn His Lys Gly Asn 
                165                 170                 175     


Phe Tyr Cys Ala Cys Leu Ser Gly Tyr Gln Trp Asn Xaa Ser Ile Cys 
            180                 185                 190         


Leu His Tyr Pro Pro Cys Gln Ser Leu His Asn His Gln Pro Cys Gly 
        195                 200                 205             


Cys Leu Val Phe Ser His Pro Glu Pro Gly Tyr Cys Gln Leu Leu Pro 
    210                 215                 220                 


Pro Gly Ser Pro Val Xaa Cys Leu Pro Ala Val Pro Gly Ile Leu Asn 
225                 230                 235                 240 


Leu Asn Ser Gln Leu Gln Met Pro Gly Asp Xaa Leu Ser Leu Xaa Leu 
                245                 250                 255     


His Leu Ser Gln Glu Ala Xaa Asn Leu Ser Trp Phe Leu Arg His Pro 
            260                 265                 270         


Gly Ser Pro Ser Pro Ile Leu Leu Gln Pro Gly Xaa Gln Val Ser Val 
        275                 280                 285             


Xaa Ser Ser His Gly Gln Ala Ala Leu Ser Val Ser Asn Met Ser His 
    290                 295                 300                 


His Trp Ala Gly Glu Tyr Met Ser Cys Phe Glu Ala Gln Gly Phe Lys 
305                 310                 315                 320 


Trp Asn Leu Tyr Glu Val Val Arg Val Pro Leu Lys Ala Xaa Asp Val 
                325                 330                 335     


Ala Arg Leu Pro Tyr Gln Leu Ser Ile Ser Cys Ala Xaa Ser Pro Gly 
            340                 345                 350         


Phe Gln Leu Ser Cys Cys Ile Pro Ser Xaa Asn Leu Ala Tyr Xaa Ala 
        355                 360                 365             


Ala Trp Ser Pro Gly Glu Gly Ser Lys Ala Ser Ser Phe Asn Glu Ser 
    370                 375                 380                 


Gly Ser Gln Cys Phe Val Leu Ala Val Gln Arg Cys Pro Met Ala Asp 
385                 390                 395                 400 


Xaa Xaa Tyr Ala Cys Asp Leu Gln Ser Leu Gly Leu Ala Pro Leu Arg 
                405                 410                 415     


Val Pro Ile Ser Ile Xaa Ile Ile Gln Asp Gly Asp Ile Xaa Cys Pro 
            420                 425                 430         


Glu Asp Ala Ser Val Leu Xaa Trp Asn Val Xaa Lys Ala Gly His Val 
        435                 440                 445             


Ala Gln Ala Pro Cys Pro Glu Ser Lys Arg Gly Ile Val Arg Arg Leu 
    450                 455                 460                 


Cys Gly Ala Asp Gly Val Trp Gly Pro Val His Ser Ser Cys Xaa Asp 
465                 470                 475                 480 


Ala Arg Leu Leu Ala Leu Phe Xaa Arg Xaa Lys Leu Leu Gln Ala Gly 
                485                 490                 495     


Gln Gly Ser Pro Ala Glu Glu Val Pro Gln Ile Leu Ala Gln Leu Pro 
            500                 505                 510         


Gly Gln Ala Ala Glu Ala Ser Ser Pro Ser Asp Leu Leu Xaa Leu Leu 
        515                 520                 525             


Ser Xaa Met Lys Tyr Val Ala Lys Val Val Ala Glu Ala Arg Ile Gln 
    530                 535                 540                 


Leu Asp Arg Arg Ala Leu Lys Asn Leu Leu Ile Ala Xaa Asp Lys Val 
545                 550                 555                 560 


Leu Asp Met Asp Xaa Arg Ser Leu Trp Xaa Leu Ala Gln Ala Arg Lys 
                565                 570                 575     


Pro Trp Ala Gly Ser Xaa Leu Leu Leu Ala Val Glu Xaa Leu Ala Cys 
            580                 585                 590         


Ser Leu Cys Pro Gln Asp His Pro Phe Ala Phe Ser Leu Pro Asn Val 
        595                 600                 605             


Leu Leu Gln Ser Gln Leu Phe Gly Pro Xaa Phe Pro Ala Asp Tyr Ser 
    610                 615                 620                 


Ile Ser Phe Pro Xaa Arg Pro Pro Leu Gln Ala Gln Ile Pro Arg His 
625                 630                 635                 640 


Ser Leu Ala Pro Leu Val Arg Asn Gly Xaa Glu Ile Ser Ile Xaa Ser 
                645                 650                 655     


Leu Val Leu Arg Lys Leu Asp His Leu Leu Pro Ser Asn Tyr Gly Gln 
            660                 665                 670         


Gly Leu Gly Asp Ser Leu Tyr Ala Xaa Pro Gly Leu Val Leu Val Ile 
        675                 680                 685             


Ser Ile Met Ala Gly Asp Arg Ala Phe Ser Gln Gly Glu Val Ile Met 
    690                 695                 700                 


Asp Phe Gly Asn Xaa Asp Gly Ser Pro His Cys Val Phe Trp Asp His 
705                 710                 715                 720 


Ser Leu Phe Gln Gly Arg Gly Gly Trp Ser Lys Glu Gly Cys Gln Ala 
                725                 730                 735     


Gln Val Ala Ser Ala Ser Pro Xaa Ala Gln Cys Leu Cys Gln His Leu 
            740                 745                 750         


Xaa Ala Phe Ser Val Leu Met Ser Pro His Xaa Val Pro Glu Glu Pro 
        755                 760                 765             


Ala Leu Ala Leu Leu Xaa Gln Val Gly Leu Gly Ala Ser Ile Leu Ala 
    770                 775                 780                 


Leu Leu Val Cys Leu Gly Val Tyr Trp Leu Val Trp Arg Val Val Val 
785                 790                 795                 800 


Arg Asn Lys Ile Ser Tyr Phe Arg His Ala Ala Leu Leu Asn Met Val 
                805                 810                 815     


Phe Cys Leu Leu Ala Ala Asp Xaa Cys Phe Leu Gly Ala Pro Phe Leu 
            820                 825                 830         


Ser Pro Gly Pro Arg Ser Pro Leu Cys Leu Ala Ala Ala Phe Leu Cys 
        835                 840                 845             


His Phe Leu Tyr Leu Ala Xaa Phe Phe Trp Met Leu Ala Gln Ala Leu 
    850                 855                 860                 


Val Leu Ala His Gln Leu Leu Phe Val Phe His Gln Leu Ala Lys His 
865                 870                 875                 880 


Arg Val Leu Pro Leu Met Val Leu Leu Gly Tyr Leu Cys Pro Leu Gly 
                885                 890                 895     


Leu Ala Gly Val Xaa Leu Gly Leu Tyr Leu Pro Gln Gly Gln Tyr Leu 
            900                 905                 910         


Arg Glu Gly Glu Cys Trp Leu Asp Gly Lys Gly Gly Ala Leu Tyr Xaa 
        915                 920                 925             


Phe Val Gly Pro Val Leu Ala Ile Ile Gly Val Asn Gly Leu Val Leu 
    930                 935                 940                 


Ala Met Ala Met Leu Lys Leu Leu Arg Pro Ser Leu Ser Glu Gly Pro 
945                 950                 955                 960 


Pro Ala Glu Lys Arg Gln Ala Leu Leu Gly Val Ile Lys Ala Leu Leu 
                965                 970                 975     


Ile Leu Xaa Pro Ile Phe Gly Leu Xaa Trp Gly Leu Gly Leu Ala Xaa 
            980                 985                 990         


Leu Leu Glu Glu Val Ser Xaa Val  Pro His Tyr Ile Phe  Xaa Ile Leu 
        995                 1000                 1005             


Asn Xaa  Leu Gln Gly Val Phe  Ile Leu Leu Phe Gly  Cys Leu Met 
    1010                 1015                 1020             


Asp Arg  Lys Ile Gln Glu Ala  Leu Arg Lys Arg Phe  Cys Arg Ala 
    1025                 1030                 1035             


Gln Ala  Pro Ser Ser Xaa Ile  Ser Leu Val Ser Cys  Cys Leu Gln 
    1040                 1045                 1050             


Ile Leu  Ser Cys Ala Ser Lys  Ser Met Ser Glu Gly  Ile Pro Trp 
    1055                 1060                 1065             


Pro Ser  Ser Glu Asp Met Gly  Xaa Ala Arg Ser 
    1070                 1075                 


<210> 1676
<211> 695
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<400> 1676
Met Lys Met Lys Ser Gln Ala Xaa Met Ile Cys Cys Leu Val Phe Phe 
1               5                   10                  15      


Leu Ser Xaa Glu Cys Ser His Tyr Arg Ser Lys Ile His Leu Lys Ala 
            20                  25                  30          


Gly Asp Lys Leu Gln Ser Pro Glu Gly Lys Pro Lys Xaa Gly Arg Ile 
        35                  40                  45              


Gln Glu Lys Cys Glu Gly Pro Cys Ile Ser Ser Ser Asn Cys Ser Gln 
    50                  55                  60                  


Pro Cys Ala Lys Asp Phe His Gly Glu Ile Gly Phe Xaa Cys Asn Gln 
65                  70                  75                  80  


Lys Lys Trp Gln Lys Ser Ala Glu Xaa Cys Xaa Ser Leu Ser Val Glu 
                85                  90                  95      


Lys Leu Phe Lys Asp Ser Xaa Gly Ala Ser Arg Leu Ser Val Ala Ala 
            100                 105                 110         


Pro Ser Ile Pro Leu His Ile Leu Asp Phe Arg Ala Pro Glu Xaa Ile 
        115                 120                 125             


Glu Ser Val Ala Gln Gly Ile Arg Lys Asn Cys Pro Phe Asp Tyr Ala 
    130                 135                 140                 


Cys Ile Xaa Asp Met Val Lys Ser Ser Glu Xaa Xaa Ser Gly Asn Ile 
145                 150                 155                 160 


Ala Phe Ile Val Glu Leu Leu Lys Asn Ile Ser Xaa Asp Leu Ser Asp 
                165                 170                 175     


Asn Val Xaa Arg Glu Lys Met Lys Ser Tyr Ser Glu Val Ala Asn His 
            180                 185                 190         


Ile Leu Asp Xaa Ala Ala Ile Ser Asn Trp Ala Phe Ile Pro Asn Lys 
        195                 200                 205             


Asn Ala Ser Ser Asp Leu Leu Gln Ser Val Asn Leu Phe Ala Arg Gln 
    210                 215                 220                 


Leu His Ile His Asn Asn Ser Glu Asn Ile Val Asn Glu Leu Phe Ile 
225                 230                 235                 240 


Gln Xaa Lys Gly Phe His Ile Asn His Asn Xaa Ser Glu Lys Ser Leu 
                245                 250                 255     


Asn Phe Ser Met Ser Met Asn Asn Xaa Xaa Glu Asp Ile Leu Gly Met 
            260                 265                 270         


Val Gln Ile Pro Arg Gln Glu Leu Arg Lys Leu Trp Pro Asn Ala Ser 
        275                 280                 285             


Gln Ala Ile Ser Ile Ala Phe Pro Xaa Leu Gly Ala Ile Leu Arg Glu 
    290                 295                 300                 


Ala His Leu Gln Asn Val Ser Leu Pro Arg Gln Val Asn Gly Leu Val 
305                 310                 315                 320 


Leu Ser Val Val Leu Pro Glu Arg Leu Gln Glu Ile Ile Leu Xaa Phe 
                325                 330                 335     


Glu Lys Ile Asn Lys Xaa Arg Asn Ala Arg Ala Gln Cys Val Gly Trp 
            340                 345                 350         


His Ser Lys Lys Arg Arg Trp Asp Glu Lys Ala Cys Gln Met Met Leu 
        355                 360                 365             


Asp Ile Arg Asn Glu Val Lys Cys Arg Cys Asn Tyr Xaa Ser Val Val 
    370                 375                 380                 


Met Ser Phe Ser Ile Leu Met Ser Ser Lys Ser Met Xaa Asp Lys Val 
385                 390                 395                 400 


Leu Asp Tyr Ile Xaa Cys Ile Gly Leu Ser Val Ser Ile Leu Ser Leu 
                405                 410                 415     


Val Leu Cys Leu Ile Ile Glu Ala Xaa Val Trp Ser Arg Val Val Val 
            420                 425                 430         


Xaa Glu Ile Ser Tyr Met Arg His Val Cys Ile Val Asn Ile Ala Val 
        435                 440                 445             


Ser Leu Leu Xaa Ala Asn Val Trp Phe Ile Ile Gly Ser His Phe Asn 
    450                 455                 460                 


Ile Lys Ala Gln Asp Tyr Asn Met Cys Val Ala Val Xaa Phe Phe Ser 
465                 470                 475                 480 


His Phe Phe Tyr Leu Ser Leu Phe Phe Trp Met Leu Phe Lys Ala Leu 
                485                 490                 495     


Leu Ile Ile Tyr Gly Ile Leu Val Ile Phe Arg Arg Met Met Lys Ser 
            500                 505                 510         


Arg Met Met Val Ile Gly Phe Ala Ile Gly Tyr Gly Cys Pro Leu Ile 
        515                 520                 525             


Ile Ala Val Xaa Xaa Val Ala Ile Xaa Glu Pro Glu Lys Gly Tyr Met 
    530                 535                 540                 


Arg Pro Glu Ala Cys Trp Leu Asn Trp Asp Asn Xaa Lys Ala Leu Leu 
545                 550                 555                 560 


Ala Phe Ala Ile Pro Ala Phe Val Ile Val Ala Val Asn Leu Ile Val 
                565                 570                 575     


Val Leu Val Val Ala Val Asn Xaa Gln Arg Pro Ser Ile Gly Ser Ser 
            580                 585                 590         


Lys Ser Gln Asp Val Val Ile Ile Met Arg Ile Ser Lys Asn Val Ala 
        595                 600                 605             


Ile Leu Xaa Pro Leu Leu Gly Leu Xaa Trp Gly Phe Gly Ile Ala Xaa 
    610                 615                 620                 


Leu Ile Glu Gly Xaa Ser Leu Xaa Phe His Ile Ile Phe Ala Leu Leu 
625                 630                 635                 640 


Asn Ala Phe Gln Gly Phe Phe Ile Leu Leu Phe Gly Xaa Ile Met Asp 
                645                 650                 655     


His Lys Ile Arg Asp Ala Leu Arg Met Arg Met Ser Ser Leu Lys Gly 
            660                 665                 670         


Lys Ser Arg Ala Ala Glu Asn Ala Ser Leu Gly Pro Xaa Asn Gly Ser 
        675                 680                 685             


Lys Leu Met Asn Arg Gln Gly 
    690                 695 


<210> 1677
<211> 752
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<400> 1677
Met Tyr Xaa Gly Pro Cys Lys Val Leu His Leu Ser Ser Gly Leu Leu 
1               5                   10                  15      


Pro Asn Ser Gly Arg Phe Gly Ile Val Leu Ser Asp Glu Tyr Gln Val 
            20                  25                  30          


Val Xaa Ser Leu Trp Cys Gln Leu Tyr Xaa Xaa His Ala Pro Gln Gln 
        35                  40                  45              


Ala Ser Gly Met Leu Leu Leu Asn Tyr Leu Val Ile Pro Ser Lys Ala 
    50                  55                  60                  


Gln Val Asn Lys Pro Gly Tyr Ile Pro Asn Leu Gly Glu Cys Ser His 
65                  70                  75                  80  


Tyr Arg Ser Lys Ile His Leu Lys Ala Gly Asp Lys Leu Gln Ser Pro 
                85                  90                  95      


Glu Gly Lys Pro Lys Xaa Gly Arg Ile Gln Glu Lys Cys Glu Gly Pro 
            100                 105                 110         


Cys Ile Ser Ser Ser Asn Cys Ser Gln Pro Cys Ala Lys Asp Phe His 
        115                 120                 125             


Gly Glu Ile Gly Phe Xaa Cys Asn Gln Lys Lys Trp Gln Lys Ser Ala 
    130                 135                 140                 


Glu Xaa Cys Xaa Ser Leu Ser Val Glu Lys Leu Phe Lys Asp Ser Xaa 
145                 150                 155                 160 


Gly Ala Ser Arg Leu Ser Val Ala Ala Pro Ser Ile Pro Leu His Ile 
                165                 170                 175     


Leu Asp Phe Arg Ala Pro Glu Xaa Ile Glu Ser Val Ala Gln Gly Ile 
            180                 185                 190         


Arg Lys Asn Cys Pro Phe Asp Tyr Ala Cys Ile Xaa Asp Met Val Lys 
        195                 200                 205             


Ser Ser Glu Xaa Xaa Ser Gly Asn Ile Ala Phe Ile Val Glu Leu Leu 
    210                 215                 220                 


Lys Asn Ile Ser Xaa Asp Leu Ser Asp Asn Val Xaa Arg Glu Lys Met 
225                 230                 235                 240 


Lys Ser Tyr Ser Glu Val Ala Asn His Ile Leu Asp Xaa Ala Ala Ile 
                245                 250                 255     


Ser Asn Trp Ala Phe Ile Pro Asn Lys Asn Ala Ser Ser Asp Leu Leu 
            260                 265                 270         


Gln Ser Val Asn Leu Phe Ala Arg Gln Leu His Ile His Asn Asn Ser 
        275                 280                 285             


Glu Asn Ile Val Asn Glu Leu Phe Ile Gln Xaa Lys Gly Phe His Ile 
    290                 295                 300                 


Asn His Asn Xaa Ser Glu Lys Ser Leu Asn Phe Ser Met Ser Met Asn 
305                 310                 315                 320 


Asn Xaa Xaa Glu Asp Ile Leu Gly Met Val Gln Ile Pro Arg Gln Glu 
                325                 330                 335     


Leu Arg Lys Leu Trp Pro Asn Ala Ser Gln Ala Ile Ser Ile Ala Phe 
            340                 345                 350         


Pro Xaa Leu Gly Ala Ile Leu Arg Glu Ala His Leu Gln Asn Val Ser 
        355                 360                 365             


Leu Pro Arg Gln Val Asn Gly Leu Val Leu Ser Val Val Leu Pro Glu 
    370                 375                 380                 


Arg Leu Gln Glu Ile Ile Leu Xaa Phe Glu Lys Ile Asn Lys Xaa Arg 
385                 390                 395                 400 


Asn Ala Arg Ala Gln Cys Val Gly Trp His Ser Lys Lys Arg Arg Trp 
                405                 410                 415     


Asp Glu Lys Ala Cys Gln Met Met Leu Asp Ile Arg Asn Glu Val Lys 
            420                 425                 430         


Cys Arg Cys Asn Tyr Xaa Ser Val Val Met Ser Phe Ser Ile Leu Met 
        435                 440                 445             


Ser Ser Lys Ser Met Xaa Asp Lys Val Leu Asp Tyr Ile Xaa Cys Ile 
    450                 455                 460                 


Gly Leu Ser Val Ser Ile Leu Ser Leu Val Leu Cys Leu Ile Ile Glu 
465                 470                 475                 480 


Ala Xaa Val Trp Ser Arg Val Val Val Xaa Glu Ile Ser Tyr Met Arg 
                485                 490                 495     


His Val Cys Ile Val Asn Ile Ala Val Ser Leu Leu Xaa Ala Asn Val 
            500                 505                 510         


Trp Phe Ile Ile Gly Ser His Phe Asn Ile Lys Ala Gln Asp Tyr Asn 
        515                 520                 525             


Met Cys Val Ala Val Xaa Phe Phe Ser His Phe Phe Tyr Leu Ser Leu 
    530                 535                 540                 


Phe Phe Trp Met Leu Phe Lys Ala Leu Leu Ile Ile Tyr Gly Ile Leu 
545                 550                 555                 560 


Val Ile Phe Arg Arg Met Met Lys Ser Arg Met Met Val Ile Gly Phe 
                565                 570                 575     


Ala Ile Gly Tyr Gly Cys Pro Leu Ile Ile Ala Val Xaa Xaa Val Ala 
            580                 585                 590         


Ile Xaa Glu Pro Glu Lys Gly Tyr Met Arg Pro Glu Ala Cys Trp Leu 
        595                 600                 605             


Asn Trp Asp Asn Xaa Lys Ala Leu Leu Ala Phe Ala Ile Pro Ala Phe 
    610                 615                 620                 


Val Ile Val Ala Val Asn Leu Ile Val Val Leu Val Val Ala Val Asn 
625                 630                 635                 640 


Xaa Gln Arg Pro Ser Ile Gly Ser Ser Lys Ser Gln Asp Val Val Ile 
                645                 650                 655     


Ile Met Arg Ile Ser Lys Asn Val Ala Ile Leu Xaa Pro Leu Leu Gly 
            660                 665                 670         


Leu Xaa Trp Gly Phe Gly Ile Ala Xaa Leu Ile Glu Gly Xaa Ser Leu 
        675                 680                 685             


Xaa Phe His Ile Ile Phe Ala Leu Leu Asn Ala Phe Gln Gly Phe Phe 
    690                 695                 700                 


Ile Leu Leu Phe Gly Xaa Ile Met Asp His Lys Ile Arg Asp Ala Leu 
705                 710                 715                 720 


Arg Met Arg Met Ser Ser Leu Lys Gly Lys Ser Arg Ala Ala Glu Asn 
                725                 730                 735     


Ala Ser Leu Gly Pro Xaa Asn Gly Ser Lys Leu Met Asn Arg Gln Gly 
            740                 745                 750         


<210> 1678
<211> 1346
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1066)..(1066)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1106)..(1106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1190)..(1190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1195)..(1195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1237)..(1238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1243)..(1243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1294)..(1294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1300)..(1300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1320)..(1320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1322)..(1322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1327)..(1327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1331)
<223> Selenocysteine

<400> 1678
Met Lys Ser Pro Arg Arg Xaa Xaa Leu Cys Leu Met Phe Ile Val Ile 
1               5                   10                  15      


Tyr Ser Ser Lys Ala Ala Leu Asn Trp Asn Tyr Glu Ser Xaa Ile His 
            20                  25                  30          


Pro Leu Ser Leu His Glu His Glu Pro Ala Gly Glu Glu Ala Leu Arg 
        35                  40                  45              


Gln Lys Arg Ala Val Ala Xaa Lys Ser Pro Xaa Ala Glu Glu Tyr Xaa 
    50                  55                  60                  


Val Asn Ile Glu Ile Ser Phe Glu Asn Ala Ser Phe Leu Asp Pro Ile 
65                  70                  75                  80  


Lys Ala Tyr Leu Asn Ser Leu Ser Phe Pro Ile His Gly Asn Asn Xaa 
                85                  90                  95      


Asp Gln Ile Xaa Asp Ile Leu Ser Ile Asn Val Xaa Xaa Val Cys Arg 
            100                 105                 110         


Pro Ala Gly Asn Glu Ile Trp Cys Ser Cys Glu Xaa Gly Tyr Gly Trp 
        115                 120                 125             


Pro Arg Glu Arg Cys Leu His Asn Leu Ile Cys Gln Glu Arg Asp Val 
    130                 135                 140                 


Phe Leu Pro Gly His His Cys Ser Cys Leu Lys Glu Leu Pro Pro Asn 
145                 150                 155                 160 


Gly Pro Phe Cys Leu Leu Gln Glu Asp Val Xaa Leu Asn Met Arg Val 
                165                 170                 175     


Arg Leu Asn Val Gly Phe Gln Glu Asp Leu Met Asn Xaa Ser Ser Ala 
            180                 185                 190         


Leu Tyr Arg Ser Tyr Lys Xaa Asp Leu Glu Xaa Ala Phe Arg Lys Gly 
        195                 200                 205             


Tyr Gly Ile Leu Pro Gly Phe Lys Gly Val Xaa Val Xaa Gly Phe Lys 
    210                 215                 220                 


Ser Gly Ser Val Val Val Xaa Tyr Glu Val Lys Xaa Xaa Pro Pro Ser 
225                 230                 235                 240 


Leu Glu Leu Ile His Lys Ala Asn Glu Gln Val Val Gln Ser Leu Asn 
                245                 250                 255     


Gln Xaa Tyr Lys Met Asp Tyr Asn Ser Phe Gln Ala Val Xaa Ile Asn 
            260                 265                 270         


Glu Ser Asn Phe Phe Val Xaa Pro Glu Ile Ile Phe Glu Gly Asp Xaa 
        275                 280                 285             


Val Ser Leu Val Cys Glu Lys Glu Val Leu Ser Ser Asn Val Ser Trp 
    290                 295                 300                 


Arg Tyr Glu Glu Gln Gln Leu Glu Ile Gln Asn Ser Ser Arg Phe Ser 
305                 310                 315                 320 


Ile Tyr Xaa Ala Leu Phe Asn Asn Met Xaa Ser Val Ser Lys Leu Xaa 
                325                 330                 335     


Ile His Asn Ile Xaa Pro Gly Asp Ala Gly Glu Tyr Val Cys Lys Leu 
            340                 345                 350         


Ile Leu Asp Ile Phe Glu Tyr Glu Cys Lys Lys Lys Ile Asp Val Met 
        355                 360                 365             


Pro Ile Gln Ile Leu Ala Asn Glu Glu Met Lys Val Met Cys Asp Asn 
    370                 375                 380                 


Asn Pro Val Ser Leu Asn Cys Cys Ser Gln Gly Asn Val Asn Trp Ser 
385                 390                 395                 400 


Lys Val Glu Trp Lys Gln Glu Gly Lys Ile Asn Ile Pro Gly Xaa Pro 
                405                 410                 415     


Glu Xaa Asp Ile Asp Ser Ser Cys Ser Arg Tyr Xaa Leu Lys Ala Asp 
            420                 425                 430         


Gly Xaa Gln Cys Pro Ser Gly Ser Ser Gly Xaa Xaa Val Ile Tyr Xaa 
        435                 440                 445             


Cys Glu Phe Ile Ser Ala Tyr Gly Ala Arg Gly Ser Ala Asn Ile Lys 
    450                 455                 460                 


Val Xaa Phe Ile Ser Val Ala Asn Leu Xaa Ile Xaa Pro Asp Pro Ile 
465                 470                 475                 480 


Ser Val Ser Glu Gly Gln Asn Phe Ser Ile Lys Cys Ile Ser Asp Val 
                485                 490                 495     


Ser Asn Tyr Asp Glu Val Tyr Trp Asn Xaa Ser Ala Gly Ile Lys Ile 
            500                 505                 510         


Tyr Gln Arg Phe Tyr Xaa Xaa Arg Arg Tyr Leu Asp Gly Ala Glu Ser 
        515                 520                 525             


Val Leu Xaa Val Lys Xaa Ser Xaa Arg Glu Trp Asn Gly Xaa Tyr His 
    530                 535                 540                 


Cys Ile Phe Arg Tyr Lys Asn Ser Tyr Ser Ile Ala Xaa Lys Asp Val 
545                 550                 555                 560 


Ile Val His Pro Leu Pro Leu Lys Leu Asn Ile Met Val Asp Pro Leu 
                565                 570                 575     


Glu Ala Xaa Val Ser Cys Ser Gly Ser His His Ile Lys Cys Cys Ile 
            580                 585                 590         


Glu Glu Asp Gly Asp Tyr Lys Val Xaa Phe His Xaa Gly Ser Ser Ser 
        595                 600                 605             


Leu Pro Ala Ala Lys Glu Val Asn Lys Lys Gln Val Cys Tyr Lys His 
    610                 615                 620                 


Asn Phe Asn Ala Ser Ser Val Ser Trp Cys Ser Lys Xaa Val Asp Val 
625                 630                 635                 640 


Cys Cys His Phe Xaa Asn Ala Ala Asn Asn Ser Val Trp Ser Pro Ser 
                645                 650                 655     


Met Lys Leu Asn Leu Val Pro Gly Glu Asn Ile Xaa Cys Gln Asp Pro 
            660                 665                 670         


Val Ile Gly Val Gly Glu Pro Gly Lys Val Ile Gln Lys Leu Cys Arg 
        675                 680                 685             


Phe Ser Asn Val Pro Ser Ser Pro Glu Ser Pro Ile Gly Gly Xaa Ile 
    690                 695                 700                 


Xaa Tyr Lys Cys Val Gly Ser Gln Trp Glu Glu Lys Arg Asn Asp Cys 
705                 710                 715                 720 


Ile Ser Ala Pro Ile Asn Ser Leu Leu Gln Met Ala Lys Ala Leu Ile 
                725                 730                 735     


Lys Ser Pro Ser Gln Asp Glu Met Leu Pro Xaa Tyr Leu Lys Asp Leu 
            740                 745                 750         


Ser Ile Ser Ile Asp Lys Ala Glu His Glu Ile Ser Ser Ser Pro Gly 
        755                 760                 765             


Ser Leu Gly Ala Ile Ile Asn Ile Leu Asp Leu Leu Ser Xaa Val Pro 
    770                 775                 780                 


Xaa Gln Val Asn Ser Glu Met Met Xaa His Val Leu Ser Xaa Val Asn 
785                 790                 795                 800 


Val Ile Leu Gly Lys Pro Val Leu Asn Xaa Trp Lys Val Leu Gln Gln 
                805                 810                 815     


Gln Trp Xaa Asn Gln Ser Ser Gln Leu Leu His Ser Val Glu Arg Phe 
            820                 825                 830         


Ser Gln Ala Leu Gln Ser Gly Asp Ser Pro Pro Leu Ser Phe Ser Gln 
        835                 840                 845             


Xaa Asn Val Gln Met Ser Ser Met Val Ile Lys Ser Ser His Pro Glu 
    850                 855                 860                 


Xaa Tyr Gln Gln Arg Phe Val Phe Pro Tyr Phe Asp Leu Trp Gly Asn 
865                 870                 875                 880 


Val Val Ile Asp Lys Ser Tyr Leu Glu Asn Leu Gln Ser Asp Ser Ser 
                885                 890                 895     


Ile Val Xaa Met Ala Phe Pro Xaa Leu Gln Ala Ile Leu Ala Gln Asp 
            900                 905                 910         


Ile Gln Glu Asn Asn Phe Ala Glu Ser Leu Val Met Xaa Xaa Xaa Val 
        915                 920                 925             


Ser His Asn Xaa Xaa Met Pro Phe Arg Ile Ser Met Xaa Phe Lys Asn 
    930                 935                 940                 


Asn Ser Pro Ser Gly Gly Glu Xaa Lys Cys Val Phe Trp Asn Phe Arg 
945                 950                 955                 960 


Leu Ala Asn Asn Xaa Gly Gly Trp Asp Ser Ser Gly Cys Tyr Val Glu 
                965                 970                 975     


Glu Gly Asp Gly Asp Asn Val Xaa Cys Ile Cys Asp His Leu Xaa Ser 
            980                 985                 990         


Phe Ser Ile Leu Met Ser Pro Asp  Ser Pro Asp Pro Ser  Ser Leu Leu 
        995                 1000                 1005             


Gly Ile  Leu Leu Asp Ile Ile  Ser Tyr Val Gly Val  Gly Phe Ser 
    1010                 1015                 1020             


Ile Leu  Ser Leu Ala Ala Cys  Leu Val Val Glu Ala  Val Val Trp 
    1025                 1030                 1035             


Lys Ser  Val Xaa Lys Asn Arg  Xaa Ser Tyr Met Arg  His Xaa Cys 
    1040                 1045                 1050             


Ile Val  Asn Ile Ala Ala Ser  Leu Leu Val Ala Asn  Xaa Trp Phe 
    1055                 1060                 1065             


Ile Val  Val Ala Ala Ile Gln  Asp Asn Arg Tyr Ile  Leu Cys Lys 
    1070                 1075                 1080             


Xaa Ala  Cys Val Ala Ala Xaa  Phe Phe Ile His Phe  Phe Tyr Leu 
    1085                 1090                 1095             


Ser Val  Phe Phe Trp Met Leu  Xaa Leu Gly Leu Met  Leu Phe Tyr 
    1100                 1105                 1110             


Arg Leu  Val Phe Ile Leu His  Glu Xaa Ser Arg Ser  Xaa Gln Lys 
    1115                 1120                 1125             


Ala Ile  Ala Phe Cys Leu Gly  Tyr Gly Cys Pro Leu  Ala Ile Ser 
    1130                 1135                 1140             


Val Ile  Xaa Leu Gly Ala Xaa  Gln Pro Arg Glu Val  Tyr Xaa Arg 
    1145                 1150                 1155             


Lys Asn  Val Cys Trp Leu Asn  Trp Glu Asp Xaa Lys  Ala Leu Leu 
    1160                 1165                 1170             


Ala Phe  Ala Ile Pro Ala Leu  Ile Ile Val Val Val  Asn Ile Xaa 
    1175                 1180                 1185             


Ile Xaa  Ile Val Val Ile Xaa  Lys Ile Leu Arg Pro  Ser Ile Gly 
    1190                 1195                 1200             


Asp Lys  Pro Cys Lys Gln Glu  Lys Ser Ser Leu Phe  Gln Ile Ser 
    1205                 1210                 1215             


Lys Ser  Ile Gly Val Leu Xaa  Pro Leu Leu Gly Leu  Xaa Trp Gly 
    1220                 1225                 1230             


Phe Gly  Leu Xaa Xaa Val Phe  Pro Gly Xaa Asn Leu  Val Phe His 
    1235                 1240                 1245             


Ile Ile  Phe Ala Ile Leu Asn  Val Phe Gln Gly Leu  Phe Ile Leu 
    1250                 1255                 1260             


Leu Phe  Gly Cys Leu Trp Asp  Leu Lys Val Gln Glu  Ala Leu Leu 
    1265                 1270                 1275             


Asn Lys  Phe Ser Leu Ser Arg  Trp Ser Ser Gln His  Ser Lys Ser 
    1280                 1285                 1290             


Xaa Ser  Leu Gly Ser Ser Xaa  Pro Val Phe Ser Met  Ser Ser Pro 
    1295                 1300                 1305             


Ile Ser  Arg Arg Phe Asn Asn  Leu Phe Gly Lys Xaa  Gly Xaa Tyr 
    1310                 1315                 1320             


Asn Val  Ser Xaa Pro Glu Ala  Xaa Ser Ser Ser Leu  Glu Asn Ser 
    1325                 1330                 1335             


Ser Ser  Ala Ser Ser Leu Leu  Asn 
    1340                 1345     


<210> 1679
<211> 6
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<400> 1679
Met Xaa Pro Gln Ser Leu 
1               5       


<210> 1680
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 1680
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala His Pro Ala Ser Arg Ser Phe Pro Asp Pro 
            20                  25                  30          


Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg His Ala Gly Arg 
        35                  40                  45              


Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu Ser Asp Lys Ala 
    50                  55                  60                  


Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser Leu Ala Gln Gly 
65                  70                  75                  80  


Pro Pro Leu Leu Ala Xaa Ser Val Xaa Ser Trp Trp Ser Pro Gln 
                85                  90                  95  


<210> 1681
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 1681
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala His Pro Ala Ser Arg Ser Phe Pro Asp Pro 
            20                  25                  30          


Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg His Ala Gly Arg 
        35                  40                  45              


Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu Ser Asp Lys Ala 
    50                  55                  60                  


Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser Leu Ala Gln Gly 
65                  70                  75                  80  


Pro Pro Leu Leu Ala Xaa Ser Val Xaa Ser Trp Trp Ser Pro Gln Asn 
                85                  90                  95      


Ile Ser Leu Pro Ser Ala Ala Ser Phe Xaa Phe Ser Phe His Ser Pro 
            100                 105                 110         


Pro His Xaa Ala Ala His Asn Ala Ser Val Asp Met Cys 
        115                 120                 125 


<210> 1682
<211> 90
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 1682
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Pro Ala Xaa Gly Ser His Leu Gln Pro Leu 
            20                  25                  30          


Pro Pro Gln Val Pro Xaa Ala Gly Ala Xaa Gly Lys Xaa Phe Ala Ser 
        35                  40                  45              


Ala Ala Ser Gly Xaa Arg His Xaa Gly Ala Ala Ser Xaa Xaa Asn Pro 
    50                  55                  60                  


His Gln Xaa Cys Ala Ser Pro Ser Arg Xaa Pro Lys Arg Pro Ser Gln 
65                  70                  75                  80  


Ser Met Pro Leu Ser Leu Gln Pro Xaa Leu 
                85                  90  


<210> 1683
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<400> 1683
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Pro Ala Xaa Gly Ser His Leu Gln Pro Leu 
            20                  25                  30          


Pro Pro Gln Val Pro Xaa Ala Gly Ala Xaa Gly Lys Xaa Phe Ala Ser 
        35                  40                  45              


Ala Ala Ser Gly Xaa Arg His Xaa Gly Ala Ala Ser Xaa Xaa Asn Pro 
    50                  55                  60                  


His Gln Xaa Cys Ala Ser Pro Ser Arg Xaa Pro Lys Arg Pro Ser Gln 
65                  70                  75                  80  


Ser Met Pro Leu Ser Leu Gln Pro Xaa Leu Leu Pro Asp Pro Ser Leu 
                85                  90                  95      


Xaa Pro Gly Ala Ser Xaa Xaa Ser Ala Ser Xaa Gly Xaa Asp Met Leu 
            100                 105                 110         


Gly Asp Tyr Ile Phe Ser 
        115             


<210> 1684
<211> 91
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<400> 1684
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Xaa Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly 
                85                  90      


<210> 1685
<211> 98
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<400> 1685
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Xaa Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr 
        


<210> 1686
<211> 103
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<400> 1686
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Xaa Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala 
            100             


<210> 1687
<211> 114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<400> 1687
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Xaa Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp 
        


<210> 1688
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<400> 1688
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Xaa Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp Phe Leu Leu Ser 
        115             


<210> 1689
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<400> 1689
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Xaa Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu Leu 
        115                 120                 125 


<210> 1690
<211> 145
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<400> 1690
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Xaa Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln 
        115                 120                 125             


His Gln Glu Glu Ser Leu Ala Gln Gly Pro Pro Leu Leu Ala Xaa Ser 
    130                 135                 140                 


Val 
145 


<210> 1691
<211> 146
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<400> 1691
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Xaa Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln 
        115                 120                 125             


His Gln Glu Glu Ser Leu Ala Gln Gly Pro Pro Leu Leu Ala Xaa Ser 
    130                 135                 140                 


Val Xaa 
145     


<210> 1692
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<400> 1692
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Xaa Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln 
        115                 120                 125             


His Gln Glu Glu Ser Leu Ala Gln Gly Pro Pro Leu Leu Ala Xaa Ser 
    130                 135                 140                 


Val Xaa Ser Trp Trp Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala 
145                 150                 155                 160 


Ser Phe Xaa Phe 
                


<210> 1693
<211> 168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<400> 1693
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Xaa Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln 
        115                 120                 125             


His Gln Glu Glu Ser Leu Ala Gln Gly Pro Pro Leu Leu Ala Xaa Ser 
    130                 135                 140                 


Val Xaa Ser Trp Trp Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala 
145                 150                 155                 160 


Ser Phe Xaa Phe Ser Phe His Ser 
                165             


<210> 1694
<211> 198
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<400> 1694
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Xaa Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln 
        115                 120                 125             


His Gln Glu Glu Ser Leu Ala Gln Gly Pro Pro Leu Leu Ala Xaa Ser 
    130                 135                 140                 


Val Xaa Ser Trp Trp Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala 
145                 150                 155                 160 


Ser Phe Xaa Phe Ser Phe His Ser Pro Pro His Xaa Ala Ala His Asn 
                165                 170                 175     


Ala Ser Val Asp Met Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser 
            180                 185                 190         


Gln Phe Leu Lys His Pro 
        195             


<210> 1695
<211> 692
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<400> 1695
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Xaa Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln 
        115                 120                 125             


His Gln Glu Glu Ser Leu Ala Gln Gly Pro Pro Leu Leu Ala Xaa Ser 
    130                 135                 140                 


Val Xaa Ser Trp Trp Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala 
145                 150                 155                 160 


Ser Phe Xaa Phe Ser Phe His Ser Pro Pro His Xaa Ala Ala His Asn 
                165                 170                 175     


Ala Ser Val Asp Met Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser 
            180                 185                 190         


Gln Phe Leu Lys His Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala 
        195                 200                 205             


Pro Ala Ser Gln Gln Leu Gln Ser Leu Glu Ser Lys Leu Xaa Ser Val 
    210                 215                 220                 


Arg Phe Met Gly Asp Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala 
225                 230                 235                 240 


Xaa Val Trp Lys Leu Gln Pro Xaa Ala Gly Leu Gln Asp Leu His Ile 
                245                 250                 255     


His Ser Arg Gln Glu Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val 
            260                 265                 270         


Leu Leu Pro Arg Xaa Leu Phe Gln Arg Xaa Lys Gly Arg Ser Gly Glu 
        275                 280                 285             


Ala Glu Lys Arg Leu Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe 
    290                 295                 300                 


Gln Asp Lys Asn Ser Ser Gln Val Leu Gly Glu Lys Val Leu Gly Ile 
305                 310                 315                 320 


Val Val Gln Asn Xaa Lys Val Ala Asn Leu Xaa Glu Pro Val Val Leu 
                325                 330                 335     


Xaa Phe Gln His Gln Leu Gln Pro Lys Asn Val Xaa Leu Gln Cys Val 
            340                 345                 350         


Phe Trp Val Glu Asp Pro Xaa Leu Ser Ser Pro Gly His Trp Ser Ser 
        355                 360                 365             


Ala Gly Cys Glu Xaa Val Arg Arg Glu Xaa Gln Xaa Ser Cys Phe Cys 
    370                 375                 380                 


Asn His Leu Xaa Tyr Phe Ala Val Leu Met Val Ser Ser Val Glu Val 
385                 390                 395                 400 


Asp Ala Val His Lys His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys 
                405                 410                 415     


Val Val Ser Ala Leu Ala Cys Leu Val Xaa Ile Ala Ala Tyr Leu Cys 
            420                 425                 430         


Ser Arg Arg Lys Pro Arg Asp Tyr Xaa Ile Lys Val His Met Asn Leu 
        435                 440                 445             


Leu Leu Ala Val Phe Leu Leu Asp Xaa Ser Phe Leu Leu Ser Glu Pro 
    450                 455                 460                 


Val Ala Leu Xaa Gly Ser Glu Ala Gly Cys Arg Ala Ser Ala Ile Phe 
465                 470                 475                 480 


Leu His Phe Ser Leu Leu Xaa Cys Leu Ser Trp Met Gly Leu Glu Gly 
                485                 490                 495     


Tyr Asn Leu Tyr Arg Leu Val Val Glu Val Phe Gly Xaa Tyr Val Pro 
            500                 505                 510         


Gly Tyr Leu Leu Lys Leu Ser Ala Met Gly Trp Gly Phe Pro Ile Phe 
        515                 520                 525             


Leu Val Xaa Leu Val Ala Leu Val Asp Val Asp Asn Tyr Gly Pro Ile 
    530                 535                 540                 


Ile Leu Ala Val His Arg Xaa Pro Glu Gly Val Ile Tyr Pro Ser Met 
545                 550                 555                 560 


Cys Trp Ile Arg Asp Ser Leu Val Ser Tyr Ile Xaa Asn Leu Gly Leu 
                565                 570                 575     


Phe Ser Leu Val Phe Leu Phe Asn Met Ala Met Leu Ala Xaa Met Val 
            580                 585                 590         


Val Gln Ile Leu Arg Leu Arg Pro His Xaa Gln Lys Trp Ser His Val 
        595                 600                 605             


Leu Xaa Leu Leu Gly Leu Ser Leu Val Leu Gly Leu Pro Trp Ala Leu 
    610                 615                 620                 


Ile Phe Phe Ser Phe Ala Ser Gly Xaa Phe Gln Leu Val Val Leu Tyr 
625                 630                 635                 640 


Leu Phe Ser Ile Ile Xaa Ser Phe Gln Gly Phe Leu Ile Phe Ile Trp 
                645                 650                 655     


Tyr Trp Ser Met Arg Leu Gln Ala Arg Gly Gly Pro Ser Pro Leu Lys 
            660                 665                 670         


Ser Asn Ser Asp Ser Ala Arg Leu Pro Ile Ser Ser Gly Ser Xaa Ser 
        675                 680                 685             


Ser Ser Arg Ile 
    690         


<210> 1696
<211> 97
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 1696
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Gly Xaa Arg His Xaa Gly Ala Ala Ser 
            20                  25                  30          


Xaa Xaa Asn Pro His Gln Xaa Cys Ala Ser Pro Ser Arg Xaa Pro Lys 
        35                  40                  45              


Arg Pro Ser Gln Ser Met Pro Leu Ser Leu Gln Pro Xaa Leu Leu Pro 
    50                  55                  60                  


Asp Pro Ser Leu Xaa Pro Gly Ala Ser Xaa Xaa Ser Ala Ser Xaa Gly 
65                  70                  75                  80  


Xaa Asp Met Leu Gly Asp Tyr Ile Phe Ser Met Ala Ser Val Xaa Ser 
                85                  90                  95      


Cys 
    


<210> 1697
<211> 68
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 1697
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu 
            20                  25                  30          


Glu Ser Leu Ala Gln Gly Pro Pro Leu Leu Ala Xaa Ser Val Xaa Ser 
        35                  40                  45              


Trp Trp Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Xaa 
    50                  55                  60                  


Phe Ser Phe His 
65              


<210> 1698
<211> 42
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<400> 1698
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His 
        35                  40          


<210> 1699
<211> 50
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<400> 1699
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro 
    50  


<210> 1700
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<400> 1700
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg 
    50                  55  


<210> 1701
<211> 56
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<400> 1701
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile 
    50                  55      


<210> 1702
<211> 70
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 1702
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro 
65                  70  


<210> 1703
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 1703
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala 
65                  70                  75          


<210> 1704
<211> 84
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 1704
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro 
                


<210> 1705
<211> 94
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 1705
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp 
                85                  90                  


<210> 1706
<211> 100
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 1706
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg 
            100 


<210> 1707
<211> 107
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 1707
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105         


<210> 1708
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 1708
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe 
            100                 105                 110 


<210> 1709
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 1709
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu 
            100                 105                 110     


<210> 1710
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 1710
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser 
    


<210> 1711
<211> 116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 1711
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala 
        115     


<210> 1712
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 1712
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu 
        115                 


<210> 1713
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 1713
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe 
        115                 120         


<210> 1714
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 1714
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln 
    130     


<210> 1715
<211> 141
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<400> 1715
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Xaa Ser Val Xaa 
    130                 135                 140     


<210> 1716
<211> 153
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<400> 1716
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Xaa Ser Val Xaa Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser 
145                 150             


<210> 1717
<211> 154
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<400> 1717
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Xaa Ser Val Xaa Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala 
145                 150                 


<210> 1718
<211> 160
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<400> 1718
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Xaa Ser Val Xaa Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Xaa Phe Ser 
145                 150                 155                 160 


<210> 1719
<211> 162
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<400> 1719
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Xaa Ser Val Xaa Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Xaa Phe Ser 
145                 150                 155                 160 


Phe His 
        


<210> 1720
<211> 167
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<400> 1720
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Xaa Ser Val Xaa Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Xaa Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Xaa 
                165         


<210> 1721
<211> 199
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<400> 1721
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Xaa Ser Val Xaa Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Xaa Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Xaa Ala Ala His Asn Ala Ser Val Asp Met 
                165                 170                 175     


Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His 
            180                 185                 190         


Pro Gln Lys Ala Ser Arg Arg 
        195                 


<210> 1722
<211> 256
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<400> 1722
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Xaa Ser Val Xaa Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Xaa Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Xaa Ala Ala His Asn Ala Ser Val Asp Met 
                165                 170                 175     


Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His 
            180                 185                 190         


Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln Gln 
        195                 200                 205             


Leu Gln Ser Leu Glu Ser Lys Leu Xaa Ser Val Arg Phe Met Gly Asp 
    210                 215                 220                 


Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala Xaa Val Trp Lys Leu 
225                 230                 235                 240 


Gln Pro Xaa Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln Glu 
                245                 250                 255     


<210> 1723
<211> 687
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<400> 1723
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Xaa Ser Val Xaa Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Xaa Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Xaa Ala Ala His Asn Ala Ser Val Asp Met 
                165                 170                 175     


Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His 
            180                 185                 190         


Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln Gln 
        195                 200                 205             


Leu Gln Ser Leu Glu Ser Lys Leu Xaa Ser Val Arg Phe Met Gly Asp 
    210                 215                 220                 


Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala Xaa Val Trp Lys Leu 
225                 230                 235                 240 


Gln Pro Xaa Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln Glu 
                245                 250                 255     


Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val Leu Leu Pro Arg Xaa 
            260                 265                 270         


Leu Phe Gln Arg Xaa Lys Gly Arg Ser Gly Glu Ala Glu Lys Arg Leu 
        275                 280                 285             


Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe Gln Asp Lys Asn Ser 
    290                 295                 300                 


Ser Gln Val Leu Gly Glu Lys Val Leu Gly Ile Val Val Gln Asn Xaa 
305                 310                 315                 320 


Lys Val Ala Asn Leu Xaa Glu Pro Val Val Leu Xaa Phe Gln His Gln 
                325                 330                 335     


Leu Gln Pro Lys Asn Val Xaa Leu Gln Cys Val Phe Trp Val Glu Asp 
            340                 345                 350         


Pro Xaa Leu Ser Ser Pro Gly His Trp Ser Ser Ala Gly Cys Glu Xaa 
        355                 360                 365             


Val Arg Arg Glu Xaa Gln Xaa Ser Cys Phe Cys Asn His Leu Xaa Tyr 
    370                 375                 380                 


Phe Ala Val Leu Met Val Ser Ser Val Glu Val Asp Ala Val His Lys 
385                 390                 395                 400 


His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys Val Val Ser Ala Leu 
                405                 410                 415     


Ala Cys Leu Val Xaa Ile Ala Ala Tyr Leu Cys Ser Arg Arg Lys Pro 
            420                 425                 430         


Arg Asp Tyr Xaa Ile Lys Val His Met Asn Leu Leu Leu Ala Val Phe 
        435                 440                 445             


Leu Leu Asp Xaa Ser Phe Leu Leu Ser Glu Pro Val Ala Leu Xaa Gly 
    450                 455                 460                 


Ser Glu Ala Gly Cys Arg Ala Ser Ala Ile Phe Leu His Phe Ser Leu 
465                 470                 475                 480 


Leu Xaa Cys Leu Ser Trp Met Gly Leu Glu Gly Tyr Asn Leu Tyr Arg 
                485                 490                 495     


Leu Val Val Glu Val Phe Gly Xaa Tyr Val Pro Gly Tyr Leu Leu Lys 
            500                 505                 510         


Leu Ser Ala Met Gly Trp Gly Phe Pro Ile Phe Leu Val Xaa Leu Val 
        515                 520                 525             


Ala Leu Val Asp Val Asp Asn Tyr Gly Pro Ile Ile Leu Ala Val His 
    530                 535                 540                 


Arg Xaa Pro Glu Gly Val Ile Tyr Pro Ser Met Cys Trp Ile Arg Asp 
545                 550                 555                 560 


Ser Leu Val Ser Tyr Ile Xaa Asn Leu Gly Leu Phe Ser Leu Val Phe 
                565                 570                 575     


Leu Phe Asn Met Ala Met Leu Ala Xaa Met Val Val Gln Ile Leu Arg 
            580                 585                 590         


Leu Arg Pro His Xaa Gln Lys Trp Ser His Val Leu Xaa Leu Leu Gly 
        595                 600                 605             


Leu Ser Leu Val Leu Gly Leu Pro Trp Ala Leu Ile Phe Phe Ser Phe 
    610                 615                 620                 


Ala Ser Gly Xaa Phe Gln Leu Val Val Leu Tyr Leu Phe Ser Ile Ile 
625                 630                 635                 640 


Xaa Ser Phe Gln Gly Phe Leu Ile Phe Ile Trp Tyr Trp Ser Met Arg 
                645                 650                 655     


Leu Gln Ala Arg Gly Gly Pro Ser Pro Leu Lys Ser Asn Ser Asp Ser 
            660                 665                 670         


Ala Arg Leu Pro Ile Ser Ser Gly Ser Xaa Ser Ser Ser Arg Ile 
        675                 680                 685         


<210> 1724
<211> 693
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<400> 1724
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Xaa His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Xaa Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Xaa Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Xaa Ser Val Xaa Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Xaa Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Xaa Ala Ala His Asn Ala Ser Val Asp Met 
                165                 170                 175     


Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His 
            180                 185                 190         


Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln Gln 
        195                 200                 205             


Leu Gln Ser Leu Glu Ser Lys Leu Xaa Ser Val Arg Phe Met Gly Asp 
    210                 215                 220                 


Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala Xaa Val Trp Lys Leu 
225                 230                 235                 240 


Gln Pro Xaa Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln Glu 
                245                 250                 255     


Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val Leu Leu Pro Arg Xaa 
            260                 265                 270         


Leu Phe Gln Arg Xaa Lys Gly Arg Ser Gly Glu Ala Glu Lys Arg Leu 
        275                 280                 285             


Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe Gln Asp Lys Asn Ser 
    290                 295                 300                 


Ser Gln Val Leu Gly Glu Lys Val Leu Gly Ile Val Val Gln Asn Xaa 
305                 310                 315                 320 


Lys Val Ala Asn Leu Xaa Glu Pro Val Val Leu Xaa Phe Gln His Gln 
                325                 330                 335     


Leu Gln Pro Lys Asn Val Xaa Leu Gln Cys Val Phe Trp Val Glu Asp 
            340                 345                 350         


Pro Xaa Leu Ser Ser Pro Gly His Trp Ser Ser Ala Gly Cys Glu Xaa 
        355                 360                 365             


Val Arg Arg Glu Xaa Gln Xaa Ser Cys Phe Cys Asn His Leu Xaa Tyr 
    370                 375                 380                 


Phe Ala Val Leu Met Val Ser Ser Val Glu Val Asp Ala Val His Lys 
385                 390                 395                 400 


His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys Val Val Ser Ala Leu 
                405                 410                 415     


Ala Cys Leu Val Xaa Ile Ala Ala Tyr Leu Cys Ser Arg Val Pro Leu 
            420                 425                 430         


Pro Cys Arg Arg Lys Pro Arg Asp Tyr Xaa Ile Lys Val His Met Asn 
        435                 440                 445             


Leu Leu Leu Ala Val Phe Leu Leu Asp Xaa Ser Phe Leu Leu Ser Glu 
    450                 455                 460                 


Pro Val Ala Leu Xaa Gly Ser Glu Ala Gly Cys Arg Ala Ser Ala Ile 
465                 470                 475                 480 


Phe Leu His Phe Ser Leu Leu Xaa Cys Leu Ser Trp Met Gly Leu Glu 
                485                 490                 495     


Gly Tyr Asn Leu Tyr Arg Leu Val Val Glu Val Phe Gly Xaa Tyr Val 
            500                 505                 510         


Pro Gly Tyr Leu Leu Lys Leu Ser Ala Met Gly Trp Gly Phe Pro Ile 
        515                 520                 525             


Phe Leu Val Xaa Leu Val Ala Leu Val Asp Val Asp Asn Tyr Gly Pro 
    530                 535                 540                 


Ile Ile Leu Ala Val His Arg Xaa Pro Glu Gly Val Ile Tyr Pro Ser 
545                 550                 555                 560 


Met Cys Trp Ile Arg Asp Ser Leu Val Ser Tyr Ile Xaa Asn Leu Gly 
                565                 570                 575     


Leu Phe Ser Leu Val Phe Leu Phe Asn Met Ala Met Leu Ala Xaa Met 
            580                 585                 590         


Val Val Gln Ile Leu Arg Leu Arg Pro His Xaa Gln Lys Trp Ser His 
        595                 600                 605             


Val Leu Xaa Leu Leu Gly Leu Ser Leu Val Leu Gly Leu Pro Trp Ala 
    610                 615                 620                 


Leu Ile Phe Phe Ser Phe Ala Ser Gly Xaa Phe Gln Leu Val Val Leu 
625                 630                 635                 640 


Tyr Leu Phe Ser Ile Ile Xaa Ser Phe Gln Gly Phe Leu Ile Phe Ile 
                645                 650                 655     


Trp Tyr Trp Ser Met Arg Leu Gln Ala Arg Gly Gly Pro Ser Pro Leu 
            660                 665                 670         


Lys Ser Asn Ser Asp Ser Ala Arg Leu Pro Ile Ser Ser Gly Ser Xaa 
        675                 680                 685             


Ser Ser Ser Arg Ile 
    690             


<210> 1725
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 1725
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Arg Cys Pro Arg Gln Gly Pro Gln Gly Arg 
            20                  25                  30          


Leu Ser Leu Leu Gln Pro Ala Glu Pro Asp Xaa Gln Glu Gln Pro Pro 
        35                  40                  45              


Leu Gln Xaa His Xaa Arg Pro Ala His Leu His Arg Glu Leu Arg Arg 
    50                  55                  60                  


Gly Pro His Ser Pro Cys Pro Phe Pro Cys Ser Pro Pro Cys 
65                  70                  75              


<210> 1726
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 1726
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Arg Cys Pro Arg Gln Gly Pro Gln Gly Arg 
            20                  25                  30          


Leu Ser Leu Leu Gln Pro Ala Glu Pro Asp Xaa Gln Glu Gln Pro Pro 
        35                  40                  45              


Leu Gln Xaa His Xaa Arg Pro Ala His Leu His Arg Glu Leu Arg Arg 
    50                  55                  60                  


Gly Pro His Ser Pro Cys Pro Phe Pro Cys Ser Pro Pro Cys Phe Pro 
65                  70                  75                  80  


Ile 
    


<210> 1727
<211> 97
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 1727
Met Xaa Pro Gln Ser Leu Leu Gln Xaa Xaa Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ser Gly Xaa Arg His Xaa Gly Ala Ala Ser 
            20                  25                  30          


Xaa Xaa Asn Pro His Gln Xaa Cys Ala Ser Pro Ser Arg Xaa Pro Lys 
        35                  40                  45              


Arg Pro Ser Gln Ser Met Pro Leu Ser Leu Gln Pro Xaa Leu Leu Pro 
    50                  55                  60                  


Asp Pro Ser Leu Xaa Pro Gly Ala Ser Xaa Xaa Ser Ala Ser Xaa Gly 
65                  70                  75                  80  


Xaa Asp Met Leu Gly Asp Tyr Ile Phe Ser Met Ala Ser Val Xaa Ser 
                85                  90                  95      


Cys 
    


<210> 1728
<211> 187
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<400> 1728
Xaa Ser Val Asp Met Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser 
1               5                   10                  15      


Gln Phe Leu Lys His Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala 
            20                  25                  30          


Pro Ala Ser Gln Gln Leu Gln Ser Leu Glu Ser Lys Leu Xaa Ser Val 
        35                  40                  45              


Arg Phe Met Gly Asp Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala 
    50                  55                  60                  


Xaa Val Trp Lys Leu Gln Pro Xaa Ala Gly Leu Gln Asp Leu His Ile 
65                  70                  75                  80  


His Ser Arg Gln Glu Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val 
                85                  90                  95      


Leu Leu Pro Arg Xaa Leu Phe Gln Arg Xaa Lys Gly Arg Ser Gly Glu 
            100                 105                 110         


Ala Glu Lys Arg Leu Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe 
        115                 120                 125             


Gln Asp Lys Asn Ser Ser Gln Val Leu Gly Glu Lys Val Phe Gly Xaa 
    130                 135                 140                 


Tyr Val Pro Gly Tyr Leu Leu Lys Leu Ser Ala Met Gly Trp Gly Phe 
145                 150                 155                 160 


Pro Ile Phe Leu Val Xaa Leu Val Ala Leu Val Asp Val Asp Asn Tyr 
                165                 170                 175     


Gly Pro Ile Ile Leu Ala Val His Arg Xaa Pro 
            180                 185         


<210> 1729
<211> 1014
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<400> 1729
Met Val Phe Ser Val Arg Gln Cys Gly His Val Gly Arg Xaa Glu Glu 
1               5                   10                  15      


Val Leu Leu Xaa Phe Lys Ile Phe Leu Val Ile Ile Cys Leu His Val 
            20                  25                  30          


Val Leu Val Xaa Ser Leu Glu Glu Asp Xaa Asp Asn Ser Ser Leu Ser 
        35                  40                  45              


Pro Pro Pro Ala Lys Leu Ser Val Val Ser Phe Ala Pro Ser Ser Asn 
    50                  55                  60                  


Glu Val Glu Xaa Xaa Ser Leu Asn Asp Val Xaa Leu Ser Leu Leu Pro 
65                  70                  75                  80  


Ser Asn Glu Xaa Glu Lys Xaa Lys Ile Xaa Ile Val Lys Xaa Phe Asn 
                85                  90                  95      


Ala Ser Gly Val Lys Pro Gln Arg Asn Ile Cys Asn Leu Ser Ser Ile 
            100                 105                 110         


Cys Asn Asp Ser Ala Phe Phe Arg Gly Glu Ile Met Phe Gln Tyr Asp 
        115                 120                 125             


Lys Glu Ser Xaa Val Pro Gln Asn Gln His Ile Xaa Asn Gly Xaa Leu 
    130                 135                 140                 


Xaa Gly Val Leu Ser Leu Ser Glu Leu Lys Arg Ser Glu Leu Asn Lys 
145                 150                 155                 160 


Xaa Leu Gln Xaa Leu Ser Glu Xaa Tyr Phe Ile Met Cys Ala Xaa Ala 
                165                 170                 175     


Glu Ala Gln Ser Xaa Leu Asn Cys Xaa Phe Xaa Ile Lys Leu Asn Asn 
            180                 185                 190         


Xaa Met Asn Ala Cys Ala Val Ile Ala Ala Leu Glu Arg Val Lys Ile 
        195                 200                 205             


Arg Pro Met Glu His Cys Cys Cys Ser Val Arg Ile Pro Cys Pro Ser 
    210                 215                 220                 


Ser Pro Glu Glu Leu Glu Lys Leu Gln Cys Asp Leu Gln Asp Pro Ile 
225                 230                 235                 240 


Val Cys Leu Ala Asp His Pro Arg Gly Pro Pro Phe Ser Ser Ser Gln 
                245                 250                 255     


Ser Ile Pro Val Val Pro Arg Ala Xaa Val Leu Ser Gln Val Pro Lys 
            260                 265                 270         


Ala Xaa Ser Phe Ala Glu Pro Pro Asp Tyr Ser Pro Val Xaa His Asn 
        275                 280                 285             


Val Pro Ser Pro Ile Gly Glu Ile Gln Pro Leu Ser Pro Gln Pro Ser 
    290                 295                 300                 


Ala Pro Ile Ala Ser Ser Pro Ala Ile Asp Met Pro Pro Gln Ser Glu 
305                 310                 315                 320 


Xaa Ile Ser Ser Pro Met Pro Gln Xaa His Val Ser Gly Xaa Pro Pro 
                325                 330                 335     


Pro Val Lys Ala Ser Phe Ser Ser Pro Xaa Val Ser Ala Pro Ala Asn 
            340                 345                 350         


Val Asn Xaa Xaa Ser Ala Pro Pro Val Gln Xaa Asp Ile Val Asn Xaa 
        355                 360                 365             


Ser Ser Ile Ser Asp Leu Glu Asn Gln Val Leu Gln Met Glu Lys Ala 
    370                 375                 380                 


Leu Ser Leu Gly Ser Leu Glu Pro Asn Leu Ala Gly Glu Met Ile Asn 
385                 390                 395                 400 


Gln Val Ser Arg Leu Leu His Ser Pro Pro Asp Met Leu Ala Pro Leu 
                405                 410                 415     


Ala Gln Arg Leu Leu Lys Val Val Asp Asp Ile Gly Leu Gln Leu Asn 
            420                 425                 430         


Phe Ser Asn Xaa Xaa Ile Ser Leu Xaa Ser Pro Ser Leu Ala Leu Ala 
        435                 440                 445             


Val Ile Arg Val Asn Ala Ser Ser Phe Asn Xaa Xaa Xaa Phe Val Ala 
    450                 455                 460                 


Gln Asp Pro Ala Asn Leu Gln Val Ser Leu Glu Xaa Gln Ala Pro Glu 
465                 470                 475                 480 


Asn Ser Ile Gly Xaa Ile Xaa Leu Pro Ser Ser Leu Met Asn Asn Leu 
                485                 490                 495     


Pro Ala His Asp Met Glu Leu Ala Ser Arg Val Gln Phe Asn Phe Phe 
            500                 505                 510         


Glu Xaa Pro Ala Leu Phe Gln Asp Pro Ser Leu Glu Asn Leu Ser Leu 
        515                 520                 525             


Ile Ser Tyr Val Ile Ser Ser Ser Val Ala Asn Leu Xaa Val Arg Asn 
    530                 535                 540                 


Leu Xaa Arg Asn Val Xaa Val Xaa Leu Lys His Ile Asn Pro Ser Gln 
545                 550                 555                 560 


Asp Glu Leu Xaa Val Arg Cys Val Phe Trp Asp Leu Gly Arg Asn Gly 
                565                 570                 575     


Gly Arg Gly Gly Trp Ser Asp Asn Gly Cys Ser Val Lys Asp Arg Arg 
            580                 585                 590         


Leu Asn Glu Xaa Ile Cys Xaa Cys Ser His Leu Xaa Ser Phe Gly Val 
        595                 600                 605             


Leu Leu Asp Leu Ser Arg Xaa Ser Val Leu Pro Ala Gln Met Met Ala 
    610                 615                 620                 


Leu Xaa Phe Ile Xaa Tyr Ile Gly Cys Gly Leu Ser Ser Ile Phe Leu 
625                 630                 635                 640 


Ser Val Xaa Leu Val Xaa Tyr Ile Ala Phe Glu Lys Ile Arg Arg Asp 
                645                 650                 655     


Tyr Pro Ser Lys Ile Leu Ile Gln Leu Cys Ala Ala Leu Leu Leu Leu 
            660                 665                 670         


Asn Leu Val Phe Leu Leu Asp Ser Trp Ile Ala Leu Tyr Lys Met Gln 
        675                 680                 685             


Gly Leu Cys Ile Ser Val Ala Val Phe Leu His Tyr Phe Leu Leu Val 
    690                 695                 700                 


Ser Phe Xaa Trp Met Gly Leu Glu Ala Phe His Met Tyr Leu Ala Leu 
705                 710                 715                 720 


Val Lys Val Phe Asn Xaa Tyr Ile Arg Lys Tyr Ile Leu Lys Phe Cys 
                725                 730                 735     


Ile Val Gly Trp Gly Val Pro Ala Val Val Val Xaa Ile Ile Leu Xaa 
            740                 745                 750         


Ile Ser Pro Asp Asn Tyr Gly Leu Gly Ser Tyr Gly Lys Phe Pro Asn 
        755                 760                 765             


Gly Ser Pro Asp Asp Phe Cys Trp Ile Asn Asn Asn Ala Val Phe Tyr 
    770                 775                 780                 


Ile Xaa Val Val Gly Tyr Phe Cys Val Ile Phe Leu Leu Asn Val Ser 
785                 790                 795                 800 


Met Phe Ile Val Val Leu Val Gln Leu Cys Arg Ile Lys Lys Lys Lys 
                805                 810                 815     


Gln Leu Gly Ala Gln Arg Lys Xaa Ser Ile Gln Asp Leu Arg Ser Ile 
            820                 825                 830         


Ala Gly Leu Xaa Phe Leu Leu Gly Ile Xaa Trp Gly Phe Ala Phe Phe 
        835                 840                 845             


Ala Trp Gly Pro Val Asn Val Xaa Phe Met Tyr Leu Phe Ala Ile Phe 
    850                 855                 860                 


Asn Xaa Leu Gln Gly Phe Phe Ile Phe Ile Phe Tyr Cys Val Ala Lys 
865                 870                 875                 880 


Glu Asn Val Arg Lys Gln Trp Arg Arg Tyr Leu Cys Cys Gly Lys Leu 
                885                 890                 895     


Arg Leu Ala Glu Asn Ser Asp Trp Ser Lys Xaa Ala Xaa Asn Gly Leu 
            900                 905                 910         


Lys Lys Gln Xaa Val Asn Gln Gly Val Ser Ser Ser Ser Asn Ser Leu 
        915                 920                 925             


Gln Ser Ser Ser Asn Ser Xaa Asn Ser Xaa Xaa Leu Leu Val Asn Asn 
    930                 935                 940                 


Asp Cys Ser Val His Ala Ser Gly Asn Gly Asn Ala Ser Xaa Glu Arg 
945                 950                 955                 960 


Asn Gly Val Ser Phe Ser Val Gln Asn Gly Asp Val Cys Leu His Asp 
                965                 970                 975     


Phe Xaa Gly Lys Gln His Met Phe Asn Glu Lys Glu Asp Ser Cys Asn 
            980                 985                 990         


Gly Lys Gly Arg Met Ala Leu Arg  Arg Xaa Ser Lys Arg  Gly Ser Leu 
        995                 1000                 1005             


His Phe  Ile Glu Gln Met 
    1010                 


<210> 1730
<211> 995
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (983)..(983)
<223> Selenocysteine

<400> 1730
Met Val Phe Ser Val Arg Gln Cys Gly His Val Gly Arg Xaa Glu Glu 
1               5                   10                  15      


Val Leu Leu Xaa Phe Lys Ile Phe Leu Val Ile Ile Cys Leu His Val 
            20                  25                  30          


Val Leu Val Xaa Ser Leu Glu Glu Asp Xaa Asp Asn Ser Ser Leu Ser 
        35                  40                  45              


Pro Pro Pro Ala Lys Leu Ser Val Val Ser Phe Ala Pro Ser Ser Asn 
    50                  55                  60                  


Gly Xaa Pro Asp Val Xaa Leu Ser Leu Leu Pro Ser Asn Glu Xaa Gly 
65                  70                  75                  80  


Val Lys Pro Gln Arg Asn Ile Cys Asn Leu Ser Ser Ile Cys Asn Asp 
                85                  90                  95      


Ser Ala Phe Phe Arg Gly Glu Ile Met Phe Gln Tyr Asp Lys Glu Ser 
            100                 105                 110         


Xaa Val Pro Gln Asn Gln His Ile Xaa Asn Gly Xaa Leu Xaa Gly Val 
        115                 120                 125             


Leu Ser Leu Ser Glu Leu Lys Arg Ser Glu Leu Asn Lys Xaa Leu Gln 
    130                 135                 140                 


Xaa Leu Ser Glu Xaa Tyr Phe Ile Met Cys Ala Xaa Ala Glu Ala Gln 
145                 150                 155                 160 


Ser Xaa Leu Asn Cys Xaa Phe Xaa Ile Lys Leu Asn Asn Xaa Met Asn 
                165                 170                 175     


Ala Cys Ala Val Ile Ala Ala Leu Glu Arg Val Lys Ile Arg Pro Met 
            180                 185                 190         


Glu His Cys Cys Cys Ser Val Arg Ile Pro Cys Pro Ser Ser Pro Glu 
        195                 200                 205             


Glu Leu Glu Lys Leu Gln Cys Asp Leu Gln Asp Pro Ile Val Cys Leu 
    210                 215                 220                 


Ala Asp His Pro Arg Gly Pro Pro Phe Ser Ser Ser Gln Ser Ile Pro 
225                 230                 235                 240 


Val Val Pro Arg Ala Xaa Val Leu Ser Gln Val Pro Lys Ala Xaa Ser 
                245                 250                 255     


Phe Ala Glu Pro Pro Asp Tyr Ser Pro Val Xaa His Asn Val Pro Ser 
            260                 265                 270         


Pro Ile Gly Glu Ile Gln Pro Leu Ser Pro Gln Pro Ser Ala Pro Ile 
        275                 280                 285             


Ala Ser Ser Pro Ala Ile Asp Met Pro Pro Gln Ser Glu Xaa Ile Ser 
    290                 295                 300                 


Ser Pro Met Pro Gln Xaa His Val Ser Gly Xaa Pro Pro Pro Val Lys 
305                 310                 315                 320 


Ala Ser Phe Ser Ser Pro Xaa Val Ser Ala Pro Ala Asn Val Asn Xaa 
                325                 330                 335     


Xaa Ser Ala Pro Pro Val Gln Xaa Asp Ile Val Asn Xaa Ser Ser Ile 
            340                 345                 350         


Ser Asp Leu Glu Asn Gln Val Leu Gln Met Glu Lys Ala Leu Ser Leu 
        355                 360                 365             


Gly Ser Leu Glu Pro Asn Leu Ala Gly Glu Met Ile Asn Gln Val Ser 
    370                 375                 380                 


Arg Leu Leu His Ser Pro Pro Asp Met Leu Ala Pro Leu Ala Gln Arg 
385                 390                 395                 400 


Leu Leu Lys Val Val Asp Asp Ile Gly Leu Gln Leu Asn Phe Ser Asn 
                405                 410                 415     


Xaa Xaa Ile Ser Leu Xaa Ser Pro Ser Leu Ala Leu Ala Val Ile Arg 
            420                 425                 430         


Val Asn Ala Ser Ser Phe Asn Xaa Xaa Xaa Phe Val Ala Gln Asp Pro 
        435                 440                 445             


Ala Asn Leu Gln Val Ser Leu Glu Xaa Gln Ala Pro Glu Asn Ser Ile 
    450                 455                 460                 


Gly Xaa Ile Xaa Leu Pro Ser Ser Leu Met Asn Asn Leu Pro Ala His 
465                 470                 475                 480 


Asp Met Glu Leu Ala Ser Arg Val Gln Phe Asn Phe Phe Glu Xaa Pro 
                485                 490                 495     


Ala Leu Phe Gln Asp Pro Ser Leu Glu Asn Leu Ser Leu Ile Ser Tyr 
            500                 505                 510         


Val Ile Ser Ser Ser Val Ala Asn Leu Xaa Val Arg Asn Leu Xaa Arg 
        515                 520                 525             


Asn Val Xaa Val Xaa Leu Lys His Ile Asn Pro Ser Gln Asp Glu Leu 
    530                 535                 540                 


Xaa Val Arg Cys Val Phe Trp Asp Leu Gly Arg Asn Gly Gly Arg Gly 
545                 550                 555                 560 


Gly Trp Ser Asp Asn Gly Cys Ser Val Lys Asp Arg Arg Leu Asn Glu 
                565                 570                 575     


Xaa Ile Cys Xaa Cys Ser His Leu Xaa Ser Phe Gly Val Leu Leu Asp 
            580                 585                 590         


Leu Ser Arg Xaa Ser Val Leu Pro Ala Gln Met Met Ala Leu Xaa Phe 
        595                 600                 605             


Ile Xaa Tyr Ile Gly Cys Gly Leu Ser Ser Ile Phe Leu Ser Val Xaa 
    610                 615                 620                 


Leu Val Xaa Tyr Ile Ala Phe Glu Lys Ile Arg Arg Asp Tyr Pro Ser 
625                 630                 635                 640 


Lys Ile Leu Ile Gln Leu Cys Ala Ala Leu Leu Leu Leu Asn Leu Val 
                645                 650                 655     


Phe Leu Leu Asp Ser Trp Ile Ala Leu Tyr Lys Met Gln Gly Leu Cys 
            660                 665                 670         


Ile Ser Val Ala Val Phe Leu His Tyr Phe Leu Leu Val Ser Phe Xaa 
        675                 680                 685             


Trp Met Gly Leu Glu Ala Phe His Met Tyr Leu Ala Leu Val Lys Val 
    690                 695                 700                 


Phe Asn Xaa Tyr Ile Arg Lys Tyr Ile Leu Lys Phe Cys Ile Val Gly 
705                 710                 715                 720 


Trp Gly Val Pro Ala Val Val Val Xaa Ile Ile Leu Xaa Ile Ser Pro 
                725                 730                 735     


Asp Asn Tyr Gly Leu Gly Ser Tyr Gly Lys Phe Pro Asn Gly Ser Pro 
            740                 745                 750         


Asp Asp Phe Cys Trp Ile Asn Asn Asn Ala Val Phe Tyr Ile Xaa Val 
        755                 760                 765             


Val Gly Tyr Phe Cys Val Ile Phe Leu Leu Asn Val Ser Met Phe Ile 
    770                 775                 780                 


Val Val Leu Val Gln Leu Cys Arg Ile Lys Lys Lys Lys Gln Leu Gly 
785                 790                 795                 800 


Ala Gln Arg Lys Xaa Ser Ile Gln Asp Leu Arg Ser Ile Ala Gly Leu 
                805                 810                 815     


Xaa Phe Leu Leu Gly Ile Xaa Trp Gly Phe Ala Phe Phe Ala Trp Gly 
            820                 825                 830         


Pro Val Asn Val Xaa Phe Met Tyr Leu Phe Ala Ile Phe Asn Xaa Leu 
        835                 840                 845             


Gln Gly Phe Phe Ile Phe Ile Phe Tyr Cys Val Ala Lys Glu Asn Val 
    850                 855                 860                 


Arg Lys Gln Trp Arg Arg Tyr Leu Cys Cys Gly Lys Leu Arg Leu Ala 
865                 870                 875                 880 


Glu Asn Ser Asp Trp Ser Lys Xaa Ala Xaa Asn Gly Leu Lys Lys Gln 
                885                 890                 895     


Xaa Val Asn Gln Gly Val Ser Ser Ser Ser Asn Ser Leu Gln Ser Ser 
            900                 905                 910         


Ser Asn Ser Xaa Asn Ser Xaa Xaa Leu Leu Val Asn Asn Asp Cys Ser 
        915                 920                 925             


Val His Ala Ser Gly Asn Gly Asn Ala Ser Xaa Glu Arg Asn Gly Val 
    930                 935                 940                 


Ser Phe Ser Val Gln Asn Gly Asp Val Cys Leu His Asp Phe Xaa Gly 
945                 950                 955                 960 


Lys Gln His Met Phe Asn Glu Lys Glu Asp Ser Cys Asn Gly Lys Gly 
                965                 970                 975     


Arg Met Ala Leu Arg Arg Xaa Ser Lys Arg Gly Ser Leu His Phe Ile 
            980                 985                 990         


Glu Gln Met 
        995 


<210> 1731
<211> 966
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<400> 1731
Met Val Phe Ser Val Arg Gln Cys Gly His Val Gly Arg Xaa Glu Glu 
1               5                   10                  15      


Val Leu Leu Xaa Phe Lys Ile Phe Leu Val Ile Ile Cys Leu His Val 
            20                  25                  30          


Val Leu Val Xaa Ser Leu Glu Glu Asp Xaa Asp Asn Ser Ser Leu Ser 
        35                  40                  45              


Pro Pro Pro Ala Lys Leu Ser Val Val Ser Phe Ala Pro Ser Ser Asn 
    50                  55                  60                  


Gly Xaa Pro Glu Val Glu Xaa Xaa Ser Leu Asn Asp Val Xaa Leu Ser 
65                  70                  75                  80  


Leu Leu Pro Ser Asn Glu Xaa Glu Lys Xaa Lys Ile Xaa Ile Val Lys 
                85                  90                  95      


Xaa Phe Asn Ala Ser Gly Val Lys Pro Gln Arg Asn Ile Cys Asn Leu 
            100                 105                 110         


Ser Ser Ile Cys Asn Asp Ser Ala Phe Phe Arg Gly Glu Ile Met Phe 
        115                 120                 125             


Gln Tyr Asp Lys Glu Ser Xaa Val Pro Gln Asn Gln His Ile Xaa Asn 
    130                 135                 140                 


Gly Xaa Leu Xaa Gly Val Leu Ser Leu Ser Glu Leu Lys Arg Ser Glu 
145                 150                 155                 160 


Leu Asn Lys Xaa Leu Gln Xaa Leu Ser Glu Xaa Tyr Phe Ile Met Cys 
                165                 170                 175     


Ala Xaa Ala Glu Ala Gln Ser Xaa Leu Asn Cys Xaa Phe Xaa Ile Lys 
            180                 185                 190         


Leu Asn Asn Xaa Met Asn Ala Cys Ala Val Ile Ala Ala Leu Glu Arg 
        195                 200                 205             


Val Lys Ile Arg Pro Met Glu His Cys Cys Cys Ser Val Arg Ile Pro 
    210                 215                 220                 


Cys Pro Ser Ser Pro Glu Glu Leu Glu Lys Leu Gln Cys Asp Leu Gln 
225                 230                 235                 240 


Asp Pro Ile Val Cys Leu Ala Asp His Pro Arg Gly Pro Pro Phe Ser 
                245                 250                 255     


Ser Ser Gln Ser Ile Pro Val Val Pro Arg Ala Xaa Val Leu Ser Gln 
            260                 265                 270         


Val Pro Lys Ala Xaa Ser Phe Ala Glu Pro Pro Asp Tyr Ser Pro Val 
        275                 280                 285             


Xaa His Asn Val Pro Ser Pro Ile Gly Glu Ile Gln Pro Leu Ser Pro 
    290                 295                 300                 


Gln Pro Ser Ala Pro Ile Ala Ser Ser Pro Ala Ile Asp Met Pro Pro 
305                 310                 315                 320 


Gln Ser Glu Xaa Ile Ser Ser Pro Met Pro Gln Xaa His Val Ser Gly 
                325                 330                 335     


Xaa Pro Pro Pro Val Lys Ala Ser Phe Ser Ser Pro Xaa Val Ser Ala 
            340                 345                 350         


Pro Ala Asn Val Asn Xaa Xaa Ser Ala Pro Pro Val Gln Xaa Asp Ile 
        355                 360                 365             


Val Asn Xaa Ser Ser Ile Ser Asp Leu Glu Asn Gln Val Leu Gln Met 
    370                 375                 380                 


Glu Lys Ala Leu Ser Leu Gly Ser Leu Glu Pro Asn Leu Ala Gly Glu 
385                 390                 395                 400 


Met Ile Asn Gln Val Ser Arg Leu Leu His Ser Pro Pro Asp Met Leu 
                405                 410                 415     


Ala Pro Leu Ala Gln Arg Leu Leu Lys Val Val Asp Asp Ile Gly Leu 
            420                 425                 430         


Gln Leu Asn Phe Ser Asn Xaa Xaa Ile Ser Leu Xaa Ser Pro Ser Leu 
        435                 440                 445             


Ala Leu Ala Val Ile Arg Val Asn Ala Ser Ser Phe Asn Xaa Xaa Xaa 
    450                 455                 460                 


Phe Val Ala Gln Asp Pro Ala Asn Leu Gln Val Ser Leu Glu Xaa Gln 
465                 470                 475                 480 


Ala Pro Glu Asn Ser Ile Gly Xaa Ile Xaa Leu Pro Ser Ser Leu Met 
                485                 490                 495     


Asn Asn Leu Pro Ala His Asp Met Glu Leu Ala Ser Arg Val Gln Phe 
            500                 505                 510         


Asn Phe Phe Glu Xaa Pro Ala Leu Phe Gln Asp Pro Ser Leu Glu Asn 
        515                 520                 525             


Leu Ser Leu Ile Ser Tyr Val Ile Ser Ser Ser Val Ala Asn Leu Xaa 
    530                 535                 540                 


Val Arg Asn Leu Xaa Arg Asn Val Xaa Val Xaa Leu Lys His Ile Asn 
545                 550                 555                 560 


Pro Ser Gln Asp Glu Leu Xaa Val Arg Cys Val Phe Trp Asp Leu Gly 
                565                 570                 575     


Arg Asn Gly Gly Arg Gly Gly Trp Ser Asp Asn Gly Cys Ser Val Lys 
            580                 585                 590         


Asp Arg Arg Leu Asn Glu Xaa Ile Cys Xaa Cys Ser His Leu Xaa Ser 
        595                 600                 605             


Phe Gly Val Leu Leu Asp Leu Ser Arg Xaa Ser Val Leu Pro Ala Gln 
    610                 615                 620                 


Met Met Ala Leu Xaa Phe Ile Xaa Tyr Ile Gly Cys Gly Leu Ser Ser 
625                 630                 635                 640 


Ile Phe Leu Ser Val Xaa Leu Val Xaa Tyr Ile Ala Phe Glu Lys Ile 
                645                 650                 655     


Arg Arg Asp Tyr Pro Ser Lys Ile Leu Ile Gln Leu Cys Ala Ala Leu 
            660                 665                 670         


Leu Leu Leu Asn Leu Val Phe Leu Leu Asp Ser Trp Ile Ala Leu Tyr 
        675                 680                 685             


Lys Met Gln Gly Leu Cys Ile Ser Val Ala Val Phe Leu His Tyr Phe 
    690                 695                 700                 


Leu Leu Val Ser Phe Xaa Trp Met Gly Leu Glu Ala Phe His Met Tyr 
705                 710                 715                 720 


Leu Ala Leu Val Lys Val Phe Asn Xaa Tyr Ile Arg Lys Tyr Ile Leu 
                725                 730                 735     


Lys Phe Cys Ile Val Gly Trp Gly Val Pro Ala Val Val Val Xaa Ile 
            740                 745                 750         


Ile Leu Xaa Ile Ser Pro Asp Asn Tyr Gly Leu Gly Ser Tyr Gly Lys 
        755                 760                 765             


Phe Pro Asn Gly Ser Pro Asp Asp Phe Cys Trp Ile Asn Asn Asn Ala 
    770                 775                 780                 


Val Phe Tyr Ile Xaa Val Val Gly Tyr Phe Cys Val Ile Phe Leu Leu 
785                 790                 795                 800 


Asn Val Ser Met Phe Ile Val Val Leu Val Gln Leu Cys Arg Ile Lys 
                805                 810                 815     


Lys Lys Lys Gln Leu Gly Ala Gln Arg Lys Xaa Ser Ile Gln Asp Leu 
            820                 825                 830         


Arg Ser Ile Ala Gly Leu Xaa Phe Leu Leu Gly Ile Xaa Trp Gly Phe 
        835                 840                 845             


Ala Phe Phe Ala Trp Gly Pro Val Asn Val Xaa Phe Met Tyr Leu Phe 
    850                 855                 860                 


Ala Ile Phe Asn Xaa Leu Gln Gly Phe Phe Ile Phe Ile Phe Tyr Cys 
865                 870                 875                 880 


Val Ala Lys Glu Asn Val Arg Lys Gln Trp Arg Arg Tyr Leu Cys Cys 
                885                 890                 895     


Gly Lys Leu Arg Leu Ala Glu Asn Ser Gly Asn Ala Ser Xaa Glu Arg 
            900                 905                 910         


Asn Gly Val Ser Phe Ser Val Gln Asn Gly Asp Val Cys Leu His Asp 
        915                 920                 925             


Phe Xaa Gly Lys Gln His Met Phe Asn Glu Lys Glu Asp Ser Cys Asn 
    930                 935                 940                 


Gly Lys Gly Arg Met Ala Leu Arg Arg Xaa Ser Lys Arg Gly Ser Leu 
945                 950                 955                 960 


His Phe Ile Glu Gln Met 
                965     


<210> 1732
<211> 1017
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<400> 1732
Met Val Phe Ser Val Arg Gln Cys Gly His Val Gly Arg Xaa Glu Glu 
1               5                   10                  15      


Val Leu Leu Xaa Phe Lys Ile Phe Leu Val Ile Ile Cys Leu His Val 
            20                  25                  30          


Val Leu Val Xaa Ser Leu Glu Glu Asp Xaa Asp Asn Ser Ser Leu Ser 
        35                  40                  45              


Pro Pro Pro Ala Lys Leu Ser Val Val Ser Phe Ala Pro Ser Ser Asn 
    50                  55                  60                  


Gly Xaa Pro Glu Val Glu Xaa Xaa Ser Leu Asn Asp Val Xaa Leu Ser 
65                  70                  75                  80  


Leu Leu Pro Ser Asn Glu Xaa Glu Lys Xaa Lys Ile Xaa Ile Val Lys 
                85                  90                  95      


Xaa Phe Asn Ala Ser Gly Val Lys Pro Gln Arg Asn Ile Cys Asn Leu 
            100                 105                 110         


Ser Ser Ile Cys Asn Asp Ser Ala Phe Phe Arg Gly Glu Ile Met Phe 
        115                 120                 125             


Gln Tyr Asp Lys Glu Ser Xaa Val Pro Gln Asn Gln His Ile Xaa Asn 
    130                 135                 140                 


Gly Xaa Leu Xaa Gly Val Leu Ser Leu Ser Glu Leu Lys Arg Ser Glu 
145                 150                 155                 160 


Leu Asn Lys Xaa Leu Gln Xaa Leu Ser Glu Xaa Tyr Phe Ile Met Cys 
                165                 170                 175     


Ala Xaa Ala Glu Ala Gln Ser Xaa Leu Asn Cys Xaa Phe Xaa Ile Lys 
            180                 185                 190         


Leu Asn Asn Xaa Met Asn Ala Cys Ala Val Ile Ala Ala Leu Glu Arg 
        195                 200                 205             


Val Lys Ile Arg Pro Met Glu His Cys Cys Cys Ser Val Arg Ile Pro 
    210                 215                 220                 


Cys Pro Ser Ser Pro Glu Glu Leu Glu Lys Leu Gln Cys Asp Leu Gln 
225                 230                 235                 240 


Asp Pro Ile Val Cys Leu Ala Asp His Pro Arg Gly Pro Pro Phe Ser 
                245                 250                 255     


Ser Ser Gln Ser Ile Pro Val Val Pro Arg Ala Xaa Val Leu Ser Gln 
            260                 265                 270         


Val Pro Lys Ala Xaa Ser Phe Ala Glu Pro Pro Asp Tyr Ser Pro Val 
        275                 280                 285             


Xaa His Asn Val Pro Ser Pro Ile Gly Glu Ile Gln Pro Leu Ser Pro 
    290                 295                 300                 


Gln Pro Ser Ala Pro Ile Ala Ser Ser Pro Ala Ile Asp Met Pro Pro 
305                 310                 315                 320 


Gln Ser Glu Xaa Ile Ser Ser Pro Met Pro Gln Xaa His Val Ser Gly 
                325                 330                 335     


Xaa Pro Pro Pro Val Lys Ala Ser Phe Ser Ser Pro Xaa Val Ser Ala 
            340                 345                 350         


Pro Ala Asn Val Asn Xaa Xaa Ser Ala Pro Pro Val Gln Xaa Asp Ile 
        355                 360                 365             


Val Asn Xaa Ser Ser Ile Ser Asp Leu Glu Asn Gln Val Leu Gln Met 
    370                 375                 380                 


Glu Lys Ala Leu Ser Leu Gly Ser Leu Glu Pro Asn Leu Ala Gly Glu 
385                 390                 395                 400 


Met Ile Asn Gln Val Ser Arg Leu Leu His Ser Pro Pro Asp Met Leu 
                405                 410                 415     


Ala Pro Leu Ala Gln Arg Leu Leu Lys Val Val Asp Asp Ile Gly Leu 
            420                 425                 430         


Gln Leu Asn Phe Ser Asn Xaa Xaa Ile Ser Leu Xaa Ser Pro Ser Leu 
        435                 440                 445             


Ala Leu Ala Val Ile Arg Val Asn Ala Ser Ser Phe Asn Xaa Xaa Xaa 
    450                 455                 460                 


Phe Val Ala Gln Asp Pro Ala Asn Leu Gln Val Ser Leu Glu Xaa Gln 
465                 470                 475                 480 


Ala Pro Glu Asn Ser Ile Gly Xaa Ile Xaa Leu Pro Ser Ser Leu Met 
                485                 490                 495     


Asn Asn Leu Pro Ala His Asp Met Glu Leu Ala Ser Arg Val Gln Phe 
            500                 505                 510         


Asn Phe Phe Glu Xaa Pro Ala Leu Phe Gln Asp Pro Ser Leu Glu Asn 
        515                 520                 525             


Leu Ser Leu Ile Ser Tyr Val Ile Ser Ser Ser Val Ala Asn Leu Xaa 
    530                 535                 540                 


Val Arg Asn Leu Xaa Arg Asn Val Xaa Val Xaa Leu Lys His Ile Asn 
545                 550                 555                 560 


Pro Ser Gln Asp Glu Leu Xaa Val Arg Cys Val Phe Trp Asp Leu Gly 
                565                 570                 575     


Arg Asn Gly Gly Arg Gly Gly Trp Ser Asp Asn Gly Cys Ser Val Lys 
            580                 585                 590         


Asp Arg Arg Leu Asn Glu Xaa Ile Cys Xaa Cys Ser His Leu Xaa Ser 
        595                 600                 605             


Phe Gly Val Leu Leu Asp Leu Ser Arg Xaa Ser Val Leu Pro Ala Gln 
    610                 615                 620                 


Met Met Ala Leu Xaa Phe Ile Xaa Tyr Ile Gly Cys Gly Leu Ser Ser 
625                 630                 635                 640 


Ile Phe Leu Ser Val Xaa Leu Val Xaa Tyr Ile Ala Phe Glu Lys Ile 
                645                 650                 655     


Arg Arg Asp Tyr Pro Ser Lys Ile Leu Ile Gln Leu Cys Ala Ala Leu 
            660                 665                 670         


Leu Leu Leu Asn Leu Val Phe Leu Leu Asp Ser Trp Ile Ala Leu Tyr 
        675                 680                 685             


Lys Met Gln Gly Leu Cys Ile Ser Val Ala Val Phe Leu His Tyr Phe 
    690                 695                 700                 


Leu Leu Val Ser Phe Xaa Trp Met Gly Leu Glu Ala Phe His Met Tyr 
705                 710                 715                 720 


Leu Ala Leu Val Lys Val Phe Asn Xaa Tyr Ile Arg Lys Tyr Ile Leu 
                725                 730                 735     


Lys Phe Cys Ile Val Gly Trp Gly Val Pro Ala Val Val Val Xaa Ile 
            740                 745                 750         


Ile Leu Xaa Ile Ser Pro Asp Asn Tyr Gly Leu Gly Ser Tyr Gly Lys 
        755                 760                 765             


Phe Pro Asn Gly Ser Pro Asp Asp Phe Cys Trp Ile Asn Asn Asn Ala 
    770                 775                 780                 


Val Phe Tyr Ile Xaa Val Val Gly Tyr Phe Cys Val Ile Phe Leu Leu 
785                 790                 795                 800 


Asn Val Ser Met Phe Ile Val Val Leu Val Gln Leu Cys Arg Ile Lys 
                805                 810                 815     


Lys Lys Lys Gln Leu Gly Ala Gln Arg Lys Xaa Ser Ile Gln Asp Leu 
            820                 825                 830         


Arg Ser Ile Ala Gly Leu Xaa Phe Leu Leu Gly Ile Xaa Trp Gly Phe 
        835                 840                 845             


Ala Phe Phe Ala Trp Gly Pro Val Asn Val Xaa Phe Met Tyr Leu Phe 
    850                 855                 860                 


Ala Ile Phe Asn Xaa Leu Gln Gly Phe Phe Ile Phe Ile Phe Tyr Cys 
865                 870                 875                 880 


Val Ala Lys Glu Asn Val Arg Lys Gln Trp Arg Arg Tyr Leu Cys Cys 
                885                 890                 895     


Gly Lys Leu Arg Leu Ala Glu Asn Ser Asp Trp Ser Lys Xaa Ala Xaa 
            900                 905                 910         


Asn Gly Leu Lys Lys Gln Xaa Val Asn Gln Gly Val Ser Ser Ser Ser 
        915                 920                 925             


Asn Ser Leu Gln Ser Ser Ser Asn Ser Xaa Asn Ser Xaa Xaa Leu Leu 
    930                 935                 940                 


Val Asn Asn Asp Cys Ser Val His Ala Ser Gly Asn Gly Asn Ala Ser 
945                 950                 955                 960 


Xaa Glu Arg Asn Gly Val Ser Phe Ser Val Gln Asn Gly Asp Val Cys 
                965                 970                 975     


Leu His Asp Phe Xaa Gly Lys Gln His Met Phe Asn Glu Lys Glu Asp 
            980                 985                 990         


Ser Cys Asn Gly Lys Gly Arg Met  Ala Leu Arg Arg Xaa  Ser Lys Arg 
        995                 1000                 1005             


Gly Ser  Leu His Phe Ile Glu  Gln Met 
    1010                 1015         


<210> 1733
<211> 1003
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<400> 1733
Met Val Phe Ser Val Arg Gln Cys Gly His Val Gly Arg Xaa Glu Glu 
1               5                   10                  15      


Val Leu Leu Xaa Phe Lys Ile Phe Leu Val Ile Ile Cys Leu His Val 
            20                  25                  30          


Val Leu Val Xaa Ser Leu Glu Glu Asp Xaa Asp Asn Ser Ser Leu Ser 
        35                  40                  45              


Pro Pro Pro Ala Lys Leu Ser Val Val Ser Phe Ala Pro Ser Ser Asn 
    50                  55                  60                  


Gly Xaa Pro Glu Val Glu Xaa Xaa Ser Leu Asn Asp Val Xaa Leu Ser 
65                  70                  75                  80  


Leu Leu Pro Ser Asn Glu Xaa Gly Val Lys Pro Gln Arg Asn Ile Cys 
                85                  90                  95      


Asn Leu Ser Ser Ile Cys Asn Asp Ser Ala Phe Phe Arg Gly Glu Ile 
            100                 105                 110         


Met Phe Gln Tyr Asp Lys Glu Ser Xaa Val Pro Gln Asn Gln His Ile 
        115                 120                 125             


Xaa Asn Gly Xaa Leu Xaa Gly Val Leu Ser Leu Ser Glu Leu Lys Arg 
    130                 135                 140                 


Ser Glu Leu Asn Lys Xaa Leu Gln Xaa Leu Ser Glu Xaa Tyr Phe Ile 
145                 150                 155                 160 


Met Cys Ala Xaa Ala Glu Ala Gln Ser Xaa Leu Asn Cys Xaa Phe Xaa 
                165                 170                 175     


Ile Lys Leu Asn Asn Xaa Met Asn Ala Cys Ala Val Ile Ala Ala Leu 
            180                 185                 190         


Glu Arg Val Lys Ile Arg Pro Met Glu His Cys Cys Cys Ser Val Arg 
        195                 200                 205             


Ile Pro Cys Pro Ser Ser Pro Glu Glu Leu Glu Lys Leu Gln Cys Asp 
    210                 215                 220                 


Leu Gln Asp Pro Ile Val Cys Leu Ala Asp His Pro Arg Gly Pro Pro 
225                 230                 235                 240 


Phe Ser Ser Ser Gln Ser Ile Pro Val Val Pro Arg Ala Xaa Val Leu 
                245                 250                 255     


Ser Gln Val Pro Lys Ala Xaa Ser Phe Ala Glu Pro Pro Asp Tyr Ser 
            260                 265                 270         


Pro Val Xaa His Asn Val Pro Ser Pro Ile Gly Glu Ile Gln Pro Leu 
        275                 280                 285             


Ser Pro Gln Pro Ser Ala Pro Ile Ala Ser Ser Pro Ala Ile Asp Met 
    290                 295                 300                 


Pro Pro Gln Ser Glu Xaa Ile Ser Ser Pro Met Pro Gln Xaa His Val 
305                 310                 315                 320 


Ser Gly Xaa Pro Pro Pro Val Lys Ala Ser Phe Ser Ser Pro Xaa Val 
                325                 330                 335     


Ser Ala Pro Ala Asn Val Asn Xaa Xaa Ser Ala Pro Pro Val Gln Xaa 
            340                 345                 350         


Asp Ile Val Asn Xaa Ser Ser Ile Ser Asp Leu Glu Asn Gln Val Leu 
        355                 360                 365             


Gln Met Glu Lys Ala Leu Ser Leu Gly Ser Leu Glu Pro Asn Leu Ala 
    370                 375                 380                 


Gly Glu Met Ile Asn Gln Val Ser Arg Leu Leu His Ser Pro Pro Asp 
385                 390                 395                 400 


Met Leu Ala Pro Leu Ala Gln Arg Leu Leu Lys Val Val Asp Asp Ile 
                405                 410                 415     


Gly Leu Gln Leu Asn Phe Ser Asn Xaa Xaa Ile Ser Leu Xaa Ser Pro 
            420                 425                 430         


Ser Leu Ala Leu Ala Val Ile Arg Val Asn Ala Ser Ser Phe Asn Xaa 
        435                 440                 445             


Xaa Xaa Phe Val Ala Gln Asp Pro Ala Asn Leu Gln Val Ser Leu Glu 
    450                 455                 460                 


Xaa Gln Ala Pro Glu Asn Ser Ile Gly Xaa Ile Xaa Leu Pro Ser Ser 
465                 470                 475                 480 


Leu Met Asn Asn Leu Pro Ala His Asp Met Glu Leu Ala Ser Arg Val 
                485                 490                 495     


Gln Phe Asn Phe Phe Glu Xaa Pro Ala Leu Phe Gln Asp Pro Ser Leu 
            500                 505                 510         


Glu Asn Leu Ser Leu Ile Ser Tyr Val Ile Ser Ser Ser Val Ala Asn 
        515                 520                 525             


Leu Xaa Val Arg Asn Leu Xaa Arg Asn Val Xaa Val Xaa Leu Lys His 
    530                 535                 540                 


Ile Asn Pro Ser Gln Asp Glu Leu Xaa Val Arg Cys Val Phe Trp Asp 
545                 550                 555                 560 


Leu Gly Arg Asn Gly Gly Arg Gly Gly Trp Ser Asp Asn Gly Cys Ser 
                565                 570                 575     


Val Lys Asp Arg Arg Leu Asn Glu Xaa Ile Cys Xaa Cys Ser His Leu 
            580                 585                 590         


Xaa Ser Phe Gly Val Leu Leu Asp Leu Ser Arg Xaa Ser Val Leu Pro 
        595                 600                 605             


Ala Gln Met Met Ala Leu Xaa Phe Ile Xaa Tyr Ile Gly Cys Gly Leu 
    610                 615                 620                 


Ser Ser Ile Phe Leu Ser Val Xaa Leu Val Xaa Tyr Ile Ala Phe Glu 
625                 630                 635                 640 


Lys Ile Arg Arg Asp Tyr Pro Ser Lys Ile Leu Ile Gln Leu Cys Ala 
                645                 650                 655     


Ala Leu Leu Leu Leu Asn Leu Val Phe Leu Leu Asp Ser Trp Ile Ala 
            660                 665                 670         


Leu Tyr Lys Met Gln Gly Leu Cys Ile Ser Val Ala Val Phe Leu His 
        675                 680                 685             


Tyr Phe Leu Leu Val Ser Phe Xaa Trp Met Gly Leu Glu Ala Phe His 
    690                 695                 700                 


Met Tyr Leu Ala Leu Val Lys Val Phe Asn Xaa Tyr Ile Arg Lys Tyr 
705                 710                 715                 720 


Ile Leu Lys Phe Cys Ile Val Gly Trp Gly Val Pro Ala Val Val Val 
                725                 730                 735     


Xaa Ile Ile Leu Xaa Ile Ser Pro Asp Asn Tyr Gly Leu Gly Ser Tyr 
            740                 745                 750         


Gly Lys Phe Pro Asn Gly Ser Pro Asp Asp Phe Cys Trp Ile Asn Asn 
        755                 760                 765             


Asn Ala Val Phe Tyr Ile Xaa Val Val Gly Tyr Phe Cys Val Ile Phe 
    770                 775                 780                 


Leu Leu Asn Val Ser Met Phe Ile Val Val Leu Val Gln Leu Cys Arg 
785                 790                 795                 800 


Ile Lys Lys Lys Lys Gln Leu Gly Ala Gln Arg Lys Xaa Ser Ile Gln 
                805                 810                 815     


Asp Leu Arg Ser Ile Ala Gly Leu Xaa Phe Leu Leu Gly Ile Xaa Trp 
            820                 825                 830         


Gly Phe Ala Phe Phe Ala Trp Gly Pro Val Asn Val Xaa Phe Met Tyr 
        835                 840                 845             


Leu Phe Ala Ile Phe Asn Xaa Leu Gln Gly Phe Phe Ile Phe Ile Phe 
    850                 855                 860                 


Tyr Cys Val Ala Lys Glu Asn Val Arg Lys Gln Trp Arg Arg Tyr Leu 
865                 870                 875                 880 


Cys Cys Gly Lys Leu Arg Leu Ala Glu Asn Ser Asp Trp Ser Lys Xaa 
                885                 890                 895     


Ala Xaa Asn Gly Leu Lys Lys Gln Xaa Val Asn Gln Gly Val Ser Ser 
            900                 905                 910         


Ser Ser Asn Ser Leu Gln Ser Ser Ser Asn Ser Xaa Asn Ser Xaa Xaa 
        915                 920                 925             


Leu Leu Val Asn Asn Asp Cys Ser Val His Ala Ser Gly Asn Gly Asn 
    930                 935                 940                 


Ala Ser Xaa Glu Arg Asn Gly Val Ser Phe Ser Val Gln Asn Gly Asp 
945                 950                 955                 960 


Val Cys Leu His Asp Phe Xaa Gly Lys Gln His Met Phe Asn Glu Lys 
                965                 970                 975     


Glu Asp Ser Cys Asn Gly Lys Gly Arg Met Ala Leu Arg Arg Xaa Ser 
            980                 985                 990         


Lys Arg Gly Ser Leu His Phe Ile  Glu Gln Met 
        995                 1000             


<210> 1734
<211> 993
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<400> 1734
Met Val Phe Ser Val Arg Gln Cys Gly His Val Gly Arg Xaa Glu Glu 
1               5                   10                  15      


Val Leu Leu Xaa Phe Lys Ile Phe Leu Val Ile Ile Cys Leu His Val 
            20                  25                  30          


Val Leu Val Xaa Ser Leu Glu Glu Asp Xaa Asp Asn Ser Ser Leu Ser 
        35                  40                  45              


Pro Pro Pro Asp Val Xaa Leu Ser Leu Leu Pro Ser Asn Glu Xaa Glu 
    50                  55                  60                  


Lys Xaa Lys Ile Xaa Ile Val Lys Xaa Phe Asn Ala Ser Gly Val Lys 
65                  70                  75                  80  


Pro Gln Arg Asn Ile Cys Asn Leu Ser Ser Ile Cys Asn Asp Ser Ala 
                85                  90                  95      


Phe Phe Arg Gly Glu Ile Met Phe Gln Tyr Asp Lys Glu Ser Xaa Val 
            100                 105                 110         


Pro Gln Asn Gln His Ile Xaa Asn Gly Xaa Leu Xaa Gly Val Leu Ser 
        115                 120                 125             


Leu Ser Glu Leu Lys Arg Ser Glu Leu Asn Lys Xaa Leu Gln Xaa Leu 
    130                 135                 140                 


Ser Glu Xaa Tyr Phe Ile Met Cys Ala Xaa Ala Glu Ala Gln Ser Xaa 
145                 150                 155                 160 


Leu Asn Cys Xaa Phe Xaa Ile Lys Leu Asn Asn Xaa Met Asn Ala Cys 
                165                 170                 175     


Ala Val Ile Ala Ala Leu Glu Arg Val Lys Ile Arg Pro Met Glu His 
            180                 185                 190         


Cys Cys Cys Ser Val Arg Ile Pro Cys Pro Ser Ser Pro Glu Glu Leu 
        195                 200                 205             


Glu Lys Leu Gln Cys Asp Leu Gln Asp Pro Ile Val Cys Leu Ala Asp 
    210                 215                 220                 


His Pro Arg Gly Pro Pro Phe Ser Ser Ser Gln Ser Ile Pro Val Val 
225                 230                 235                 240 


Pro Arg Ala Xaa Val Leu Ser Gln Val Pro Lys Ala Xaa Ser Phe Ala 
                245                 250                 255     


Glu Pro Pro Asp Tyr Ser Pro Val Xaa His Asn Val Pro Ser Pro Ile 
            260                 265                 270         


Gly Glu Ile Gln Pro Leu Ser Pro Gln Pro Ser Ala Pro Ile Ala Ser 
        275                 280                 285             


Ser Pro Ala Ile Asp Met Pro Pro Gln Ser Glu Xaa Ile Ser Ser Pro 
    290                 295                 300                 


Met Pro Gln Xaa His Val Ser Gly Xaa Pro Pro Pro Val Lys Ala Ser 
305                 310                 315                 320 


Phe Ser Ser Pro Xaa Val Ser Ala Pro Ala Asn Val Asn Xaa Xaa Ser 
                325                 330                 335     


Ala Pro Pro Val Gln Xaa Asp Ile Val Asn Xaa Ser Ser Ile Ser Asp 
            340                 345                 350         


Leu Glu Asn Gln Val Leu Gln Met Glu Lys Ala Leu Ser Leu Gly Ser 
        355                 360                 365             


Leu Glu Pro Asn Leu Ala Gly Glu Met Ile Asn Gln Val Ser Arg Leu 
    370                 375                 380                 


Leu His Ser Pro Pro Asp Met Leu Ala Pro Leu Ala Gln Arg Leu Leu 
385                 390                 395                 400 


Lys Val Val Asp Asp Ile Gly Leu Gln Leu Asn Phe Ser Asn Xaa Xaa 
                405                 410                 415     


Ile Ser Leu Xaa Ser Pro Ser Leu Ala Leu Ala Val Ile Arg Val Asn 
            420                 425                 430         


Ala Ser Ser Phe Asn Xaa Xaa Xaa Phe Val Ala Gln Asp Pro Ala Asn 
        435                 440                 445             


Leu Gln Val Ser Leu Glu Xaa Gln Ala Pro Glu Asn Ser Ile Gly Xaa 
    450                 455                 460                 


Ile Xaa Leu Pro Ser Ser Leu Met Asn Asn Leu Pro Ala His Asp Met 
465                 470                 475                 480 


Glu Leu Ala Ser Arg Val Gln Phe Asn Phe Phe Glu Xaa Pro Ala Leu 
                485                 490                 495     


Phe Gln Asp Pro Ser Leu Glu Asn Leu Ser Leu Ile Ser Tyr Val Ile 
            500                 505                 510         


Ser Ser Ser Val Ala Asn Leu Xaa Val Arg Asn Leu Xaa Arg Asn Val 
        515                 520                 525             


Xaa Val Xaa Leu Lys His Ile Asn Pro Ser Gln Asp Glu Leu Xaa Val 
    530                 535                 540                 


Arg Cys Val Phe Trp Asp Leu Gly Arg Asn Gly Gly Arg Gly Gly Trp 
545                 550                 555                 560 


Ser Asp Asn Gly Cys Ser Val Lys Asp Arg Arg Leu Asn Glu Xaa Ile 
                565                 570                 575     


Cys Xaa Cys Ser His Leu Xaa Ser Phe Gly Val Leu Leu Asp Leu Ser 
            580                 585                 590         


Arg Xaa Ser Val Leu Pro Ala Gln Met Met Ala Leu Xaa Phe Ile Xaa 
        595                 600                 605             


Tyr Ile Gly Cys Gly Leu Ser Ser Ile Phe Leu Ser Val Xaa Leu Val 
    610                 615                 620                 


Xaa Tyr Ile Ala Phe Glu Lys Ile Arg Arg Asp Tyr Pro Ser Lys Ile 
625                 630                 635                 640 


Leu Ile Gln Leu Cys Ala Ala Leu Leu Leu Leu Asn Leu Val Phe Leu 
                645                 650                 655     


Leu Asp Ser Trp Ile Ala Leu Tyr Lys Met Gln Gly Leu Cys Ile Ser 
            660                 665                 670         


Val Ala Val Phe Leu His Tyr Phe Leu Leu Val Ser Phe Xaa Trp Met 
        675                 680                 685             


Gly Leu Glu Ala Phe His Met Tyr Leu Ala Leu Val Lys Val Phe Asn 
    690                 695                 700                 


Xaa Tyr Ile Arg Lys Tyr Ile Leu Lys Phe Cys Ile Val Gly Trp Gly 
705                 710                 715                 720 


Val Pro Ala Val Val Val Xaa Ile Ile Leu Xaa Ile Ser Pro Asp Asn 
                725                 730                 735     


Tyr Gly Leu Gly Ser Tyr Gly Lys Phe Pro Asn Gly Ser Pro Asp Asp 
            740                 745                 750         


Phe Cys Trp Ile Asn Asn Asn Ala Val Phe Tyr Ile Xaa Val Val Gly 
        755                 760                 765             


Tyr Phe Cys Val Ile Phe Leu Leu Asn Val Ser Met Phe Ile Val Val 
    770                 775                 780                 


Leu Val Gln Leu Cys Arg Ile Lys Lys Lys Lys Gln Leu Gly Ala Gln 
785                 790                 795                 800 


Arg Lys Xaa Ser Ile Gln Asp Leu Arg Ser Ile Ala Gly Leu Xaa Phe 
                805                 810                 815     


Leu Leu Gly Ile Xaa Trp Gly Phe Ala Phe Phe Ala Trp Gly Pro Val 
            820                 825                 830         


Asn Val Xaa Phe Met Tyr Leu Phe Ala Ile Phe Asn Xaa Leu Gln Gly 
        835                 840                 845             


Phe Phe Ile Phe Ile Phe Tyr Cys Val Ala Lys Glu Asn Val Arg Lys 
    850                 855                 860                 


Gln Trp Arg Arg Tyr Leu Cys Cys Gly Lys Leu Arg Leu Ala Glu Asn 
865                 870                 875                 880 


Ser Asp Trp Ser Lys Xaa Ala Xaa Asn Gly Leu Lys Lys Gln Xaa Val 
                885                 890                 895     


Asn Gln Gly Val Ser Ser Ser Ser Asn Ser Leu Gln Ser Ser Ser Asn 
            900                 905                 910         


Ser Xaa Asn Ser Xaa Xaa Leu Leu Val Asn Asn Asp Cys Ser Val His 
        915                 920                 925             


Ala Ser Gly Asn Gly Asn Ala Ser Xaa Glu Arg Asn Gly Val Ser Phe 
    930                 935                 940                 


Ser Val Gln Asn Gly Asp Val Cys Leu His Asp Phe Xaa Gly Lys Gln 
945                 950                 955                 960 


His Met Phe Asn Glu Lys Glu Asp Ser Cys Asn Gly Lys Gly Arg Met 
                965                 970                 975     


Ala Leu Arg Arg Xaa Ser Lys Arg Gly Ser Leu His Phe Ile Glu Gln 
            980                 985                 990         


Met 
    


<210> 1735
<211> 1001
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<400> 1735
Met Val Phe Ser Val Arg Gln Cys Gly His Val Gly Arg Xaa Glu Glu 
1               5                   10                  15      


Val Leu Leu Xaa Phe Lys Ile Phe Leu Val Ile Ile Cys Leu His Val 
            20                  25                  30          


Val Leu Val Xaa Ser Leu Glu Glu Asp Xaa Asp Asn Ser Ser Leu Ser 
        35                  40                  45              


Pro Pro Pro Glu Val Glu Xaa Xaa Ser Leu Asn Asp Val Xaa Leu Ser 
    50                  55                  60                  


Leu Leu Pro Ser Asn Glu Xaa Glu Lys Xaa Lys Ile Xaa Ile Val Lys 
65                  70                  75                  80  


Xaa Phe Asn Ala Ser Gly Val Lys Pro Gln Arg Asn Ile Cys Asn Leu 
                85                  90                  95      


Ser Ser Ile Cys Asn Asp Ser Ala Phe Phe Arg Gly Glu Ile Met Phe 
            100                 105                 110         


Gln Tyr Asp Lys Glu Ser Xaa Val Pro Gln Asn Gln His Ile Xaa Asn 
        115                 120                 125             


Gly Xaa Leu Xaa Gly Val Leu Ser Leu Ser Glu Leu Lys Arg Ser Glu 
    130                 135                 140                 


Leu Asn Lys Xaa Leu Gln Xaa Leu Ser Glu Xaa Tyr Phe Ile Met Cys 
145                 150                 155                 160 


Ala Xaa Ala Glu Ala Gln Ser Xaa Leu Asn Cys Xaa Phe Xaa Ile Lys 
                165                 170                 175     


Leu Asn Asn Xaa Met Asn Ala Cys Ala Val Ile Ala Ala Leu Glu Arg 
            180                 185                 190         


Val Lys Ile Arg Pro Met Glu His Cys Cys Cys Ser Val Arg Ile Pro 
        195                 200                 205             


Cys Pro Ser Ser Pro Glu Glu Leu Glu Lys Leu Gln Cys Asp Leu Gln 
    210                 215                 220                 


Asp Pro Ile Val Cys Leu Ala Asp His Pro Arg Gly Pro Pro Phe Ser 
225                 230                 235                 240 


Ser Ser Gln Ser Ile Pro Val Val Pro Arg Ala Xaa Val Leu Ser Gln 
                245                 250                 255     


Val Pro Lys Ala Xaa Ser Phe Ala Glu Pro Pro Asp Tyr Ser Pro Val 
            260                 265                 270         


Xaa His Asn Val Pro Ser Pro Ile Gly Glu Ile Gln Pro Leu Ser Pro 
        275                 280                 285             


Gln Pro Ser Ala Pro Ile Ala Ser Ser Pro Ala Ile Asp Met Pro Pro 
    290                 295                 300                 


Gln Ser Glu Xaa Ile Ser Ser Pro Met Pro Gln Xaa His Val Ser Gly 
305                 310                 315                 320 


Xaa Pro Pro Pro Val Lys Ala Ser Phe Ser Ser Pro Xaa Val Ser Ala 
                325                 330                 335     


Pro Ala Asn Val Asn Xaa Xaa Ser Ala Pro Pro Val Gln Xaa Asp Ile 
            340                 345                 350         


Val Asn Xaa Ser Ser Ile Ser Asp Leu Glu Asn Gln Val Leu Gln Met 
        355                 360                 365             


Glu Lys Ala Leu Ser Leu Gly Ser Leu Glu Pro Asn Leu Ala Gly Glu 
    370                 375                 380                 


Met Ile Asn Gln Val Ser Arg Leu Leu His Ser Pro Pro Asp Met Leu 
385                 390                 395                 400 


Ala Pro Leu Ala Gln Arg Leu Leu Lys Val Val Asp Asp Ile Gly Leu 
                405                 410                 415     


Gln Leu Asn Phe Ser Asn Xaa Xaa Ile Ser Leu Xaa Ser Pro Ser Leu 
            420                 425                 430         


Ala Leu Ala Val Ile Arg Val Asn Ala Ser Ser Phe Asn Xaa Xaa Xaa 
        435                 440                 445             


Phe Val Ala Gln Asp Pro Ala Asn Leu Gln Val Ser Leu Glu Xaa Gln 
    450                 455                 460                 


Ala Pro Glu Asn Ser Ile Gly Xaa Ile Xaa Leu Pro Ser Ser Leu Met 
465                 470                 475                 480 


Asn Asn Leu Pro Ala His Asp Met Glu Leu Ala Ser Arg Val Gln Phe 
                485                 490                 495     


Asn Phe Phe Glu Xaa Pro Ala Leu Phe Gln Asp Pro Ser Leu Glu Asn 
            500                 505                 510         


Leu Ser Leu Ile Ser Tyr Val Ile Ser Ser Ser Val Ala Asn Leu Xaa 
        515                 520                 525             


Val Arg Asn Leu Xaa Arg Asn Val Xaa Val Xaa Leu Lys His Ile Asn 
    530                 535                 540                 


Pro Ser Gln Asp Glu Leu Xaa Val Arg Cys Val Phe Trp Asp Leu Gly 
545                 550                 555                 560 


Arg Asn Gly Gly Arg Gly Gly Trp Ser Asp Asn Gly Cys Ser Val Lys 
                565                 570                 575     


Asp Arg Arg Leu Asn Glu Xaa Ile Cys Xaa Cys Ser His Leu Xaa Ser 
            580                 585                 590         


Phe Gly Val Leu Leu Asp Leu Ser Arg Xaa Ser Val Leu Pro Ala Gln 
        595                 600                 605             


Met Met Ala Leu Xaa Phe Ile Xaa Tyr Ile Gly Cys Gly Leu Ser Ser 
    610                 615                 620                 


Ile Phe Leu Ser Val Xaa Leu Val Xaa Tyr Ile Ala Phe Glu Lys Ile 
625                 630                 635                 640 


Arg Arg Asp Tyr Pro Ser Lys Ile Leu Ile Gln Leu Cys Ala Ala Leu 
                645                 650                 655     


Leu Leu Leu Asn Leu Val Phe Leu Leu Asp Ser Trp Ile Ala Leu Tyr 
            660                 665                 670         


Lys Met Gln Gly Leu Cys Ile Ser Val Ala Val Phe Leu His Tyr Phe 
        675                 680                 685             


Leu Leu Val Ser Phe Xaa Trp Met Gly Leu Glu Ala Phe His Met Tyr 
    690                 695                 700                 


Leu Ala Leu Val Lys Val Phe Asn Xaa Tyr Ile Arg Lys Tyr Ile Leu 
705                 710                 715                 720 


Lys Phe Cys Ile Val Gly Trp Gly Val Pro Ala Val Val Val Xaa Ile 
                725                 730                 735     


Ile Leu Xaa Ile Ser Pro Asp Asn Tyr Gly Leu Gly Ser Tyr Gly Lys 
            740                 745                 750         


Phe Pro Asn Gly Ser Pro Asp Asp Phe Cys Trp Ile Asn Asn Asn Ala 
        755                 760                 765             


Val Phe Tyr Ile Xaa Val Val Gly Tyr Phe Cys Val Ile Phe Leu Leu 
    770                 775                 780                 


Asn Val Ser Met Phe Ile Val Val Leu Val Gln Leu Cys Arg Ile Lys 
785                 790                 795                 800 


Lys Lys Lys Gln Leu Gly Ala Gln Arg Lys Xaa Ser Ile Gln Asp Leu 
                805                 810                 815     


Arg Ser Ile Ala Gly Leu Xaa Phe Leu Leu Gly Ile Xaa Trp Gly Phe 
            820                 825                 830         


Ala Phe Phe Ala Trp Gly Pro Val Asn Val Xaa Phe Met Tyr Leu Phe 
        835                 840                 845             


Ala Ile Phe Asn Xaa Leu Gln Gly Phe Phe Ile Phe Ile Phe Tyr Cys 
    850                 855                 860                 


Val Ala Lys Glu Asn Val Arg Lys Gln Trp Arg Arg Tyr Leu Cys Cys 
865                 870                 875                 880 


Gly Lys Leu Arg Leu Ala Glu Asn Ser Asp Trp Ser Lys Xaa Ala Xaa 
                885                 890                 895     


Asn Gly Leu Lys Lys Gln Xaa Val Asn Gln Gly Val Ser Ser Ser Ser 
            900                 905                 910         


Asn Ser Leu Gln Ser Ser Ser Asn Ser Xaa Asn Ser Xaa Xaa Leu Leu 
        915                 920                 925             


Val Asn Asn Asp Cys Ser Val His Ala Ser Gly Asn Gly Asn Ala Ser 
    930                 935                 940                 


Xaa Glu Arg Asn Gly Val Ser Phe Ser Val Gln Asn Gly Asp Val Cys 
945                 950                 955                 960 


Leu His Asp Phe Xaa Gly Lys Gln His Met Phe Asn Glu Lys Glu Asp 
                965                 970                 975     


Ser Cys Asn Gly Lys Gly Arg Met Ala Leu Arg Arg Xaa Ser Lys Arg 
            980                 985                 990         


Gly Ser Leu His Phe Ile Glu Gln  Met 
        995                 1000     


<210> 1736
<211> 898
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<400> 1736
Met Val Phe Ser Val Arg Gln Cys Gly His Val Gly Arg Xaa Glu Glu 
1               5                   10                  15      


Val Leu Leu Xaa Phe Lys Ile Phe Leu Val Ile Ile Cys Leu His Val 
            20                  25                  30          


Val Leu Val Xaa Ser Leu Glu Glu Asp Xaa Asp Asn Ser Ser Leu Ser 
        35                  40                  45              


Pro Pro Pro Glu Val Glu Xaa Xaa Ser Leu Asn Asp Val Xaa Leu Ser 
    50                  55                  60                  


Leu Leu Pro Ser Asn Glu Xaa Gly Val Lys Pro Gln Arg Asn Ile Cys 
65                  70                  75                  80  


Asn Leu Ser Ser Ile Cys Asn Asp Ser Ala Phe Phe Arg Gly Glu Ile 
                85                  90                  95      


Met Phe Gln Tyr Asp Lys Glu Ser Xaa Val Pro Gln Asn Gln His Ile 
            100                 105                 110         


Xaa Asn Gly Xaa Leu Xaa Gly Val Leu Ser Leu Ser Glu Leu Lys Arg 
        115                 120                 125             


Ser Glu Leu Asn Lys Xaa Leu Gln Xaa Leu Ser Glu Xaa Tyr Phe Ile 
    130                 135                 140                 


Met Cys Ala Xaa Ala Glu Ala Gln Ser Xaa Leu Asn Cys Xaa Phe Xaa 
145                 150                 155                 160 


Ile Lys Leu Asn Asn Xaa Met Asn Ala Cys Ala Val Ile Ala Ala Leu 
                165                 170                 175     


Glu Arg Val Lys Ile Arg Pro Met Glu His Cys Cys Cys Ser Val Arg 
            180                 185                 190         


Ile Pro Cys Pro Ser Ser Pro Glu Glu Leu Glu Lys Leu Gln Cys Asp 
        195                 200                 205             


Leu Gln Asp Pro Ile Val Cys Leu Ala Asp His Pro Arg Gly Pro Pro 
    210                 215                 220                 


Phe Ser Ser Ser Gln Ser Ile Pro Val Val Pro Arg Ala Xaa Val Leu 
225                 230                 235                 240 


Ser Gln Val Pro Lys Ala Xaa Ser Phe Ala Glu Pro Pro Asp Tyr Ser 
                245                 250                 255     


Pro Val Xaa His Asn Val Pro Ser Pro Ile Gly Glu Ile Gln Pro Leu 
            260                 265                 270         


Ser Pro Gln Pro Ser Ala Pro Ile Ala Ser Ser Pro Ala Ile Asp Met 
        275                 280                 285             


Pro Pro Gln Ser Glu Xaa Ile Ser Ser Pro Met Pro Gln Xaa His Val 
    290                 295                 300                 


Ser Gly Xaa Pro Pro Pro Val Lys Ala Ser Phe Ser Ser Pro Xaa Val 
305                 310                 315                 320 


Ser Ala Pro Ala Asn Val Asn Xaa Xaa Ser Ala Pro Pro Val Gln Xaa 
                325                 330                 335     


Asp Ile Val Asn Xaa Ser Ser Ile Ser Asp Leu Glu Asn Gln Val Leu 
            340                 345                 350         


Gln Met Glu Lys Ala Leu Ser Leu Gly Ser Leu Glu Pro Asn Leu Ala 
        355                 360                 365             


Gly Glu Met Ile Asn Gln Val Ser Arg Leu Leu His Ser Pro Pro Asp 
    370                 375                 380                 


Met Leu Ala Pro Leu Ala Gln Arg Leu Leu Lys Val Val Asp Asp Ile 
385                 390                 395                 400 


Gly Leu Gln Leu Asn Phe Ser Asn Xaa Xaa Ile Ser Leu Xaa Ser Pro 
                405                 410                 415     


Ser Leu Ala Leu Ala Val Ile Arg Val Asn Ala Ser Ser Phe Asn Xaa 
            420                 425                 430         


Xaa Xaa Phe Val Ala Gln Asp Pro Ala Asn Leu Gln Asp Glu Leu Xaa 
        435                 440                 445             


Val Arg Cys Val Phe Trp Asp Leu Gly Arg Asn Gly Gly Arg Gly Gly 
    450                 455                 460                 


Trp Ser Asp Asn Gly Cys Ser Val Lys Asp Arg Arg Leu Asn Glu Xaa 
465                 470                 475                 480 


Ile Cys Xaa Cys Ser His Leu Xaa Ser Phe Gly Val Leu Leu Asp Leu 
                485                 490                 495     


Ser Arg Xaa Ser Val Leu Pro Ala Gln Met Met Ala Leu Xaa Phe Ile 
            500                 505                 510         


Xaa Tyr Ile Gly Cys Gly Leu Ser Ser Ile Phe Leu Ser Val Xaa Leu 
        515                 520                 525             


Val Xaa Tyr Ile Ala Phe Glu Lys Ile Arg Arg Asp Tyr Pro Ser Lys 
    530                 535                 540                 


Ile Leu Ile Gln Leu Cys Ala Ala Leu Leu Leu Leu Asn Leu Val Phe 
545                 550                 555                 560 


Leu Leu Asp Ser Trp Ile Ala Leu Tyr Lys Met Gln Gly Leu Cys Ile 
                565                 570                 575     


Ser Val Ala Val Phe Leu His Tyr Phe Leu Leu Val Ser Phe Xaa Trp 
            580                 585                 590         


Met Gly Leu Glu Ala Phe His Met Tyr Leu Ala Leu Val Lys Val Phe 
        595                 600                 605             


Asn Xaa Tyr Ile Arg Lys Tyr Ile Leu Lys Phe Cys Ile Val Gly Trp 
    610                 615                 620                 


Gly Val Pro Ala Val Val Val Xaa Ile Ile Leu Xaa Ile Ser Pro Asp 
625                 630                 635                 640 


Asn Tyr Gly Leu Gly Ser Tyr Gly Lys Phe Pro Asn Gly Ser Pro Asp 
                645                 650                 655     


Asp Phe Cys Trp Ile Asn Asn Asn Ala Val Phe Tyr Ile Xaa Val Val 
            660                 665                 670         


Gly Tyr Phe Cys Val Ile Phe Leu Leu Asn Val Ser Met Phe Ile Val 
        675                 680                 685             


Val Leu Val Gln Leu Cys Arg Ile Lys Lys Lys Lys Gln Leu Gly Ala 
    690                 695                 700                 


Gln Arg Lys Xaa Ser Ile Gln Asp Leu Arg Ser Ile Ala Gly Leu Xaa 
705                 710                 715                 720 


Phe Leu Leu Gly Ile Xaa Trp Gly Phe Ala Phe Phe Ala Trp Gly Pro 
                725                 730                 735     


Val Asn Val Xaa Phe Met Tyr Leu Phe Ala Ile Phe Asn Xaa Leu Gln 
            740                 745                 750         


Gly Phe Phe Ile Phe Ile Phe Tyr Cys Val Ala Lys Glu Asn Val Arg 
        755                 760                 765             


Lys Gln Trp Arg Arg Tyr Leu Cys Cys Gly Lys Leu Arg Leu Ala Glu 
    770                 775                 780                 


Asn Ser Asp Trp Ser Lys Xaa Ala Xaa Asn Gly Leu Lys Lys Gln Xaa 
785                 790                 795                 800 


Val Asn Gln Gly Val Ser Ser Ser Ser Asn Ser Leu Gln Ser Ser Ser 
                805                 810                 815     


Asn Ser Xaa Asn Ser Xaa Xaa Leu Leu Val Asn Asn Asp Cys Ser Val 
            820                 825                 830         


His Ala Ser Gly Asn Gly Asn Ala Ser Xaa Glu Arg Asn Gly Val Ser 
        835                 840                 845             


Phe Ser Val Gln Asn Gly Asp Val Cys Leu His Asp Phe Xaa Gly Lys 
    850                 855                 860                 


Gln His Met Phe Asn Glu Lys Glu Asp Ser Cys Asn Gly Lys Gly Arg 
865                 870                 875                 880 


Met Ala Leu Arg Arg Xaa Ser Lys Arg Gly Ser Leu His Phe Ile Glu 
                885                 890                 895     


Gln Met 
        


<210> 1737
<211> 987
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<400> 1737
Met Val Phe Ser Val Arg Gln Cys Gly His Val Gly Arg Xaa Glu Glu 
1               5                   10                  15      


Val Leu Leu Xaa Phe Lys Ile Phe Leu Val Ile Ile Cys Leu His Val 
            20                  25                  30          


Val Leu Val Xaa Ser Leu Glu Glu Asp Xaa Asp Asn Ser Ser Leu Ser 
        35                  40                  45              


Pro Pro Pro Glu Val Glu Xaa Xaa Ser Leu Asn Asp Val Xaa Leu Ser 
    50                  55                  60                  


Leu Leu Pro Ser Asn Glu Xaa Gly Val Lys Pro Gln Arg Asn Ile Cys 
65                  70                  75                  80  


Asn Leu Ser Ser Ile Cys Asn Asp Ser Ala Phe Phe Arg Gly Glu Ile 
                85                  90                  95      


Met Phe Gln Tyr Asp Lys Glu Ser Xaa Val Pro Gln Asn Gln His Ile 
            100                 105                 110         


Xaa Asn Gly Xaa Leu Xaa Gly Val Leu Ser Leu Ser Glu Leu Lys Arg 
        115                 120                 125             


Ser Glu Leu Asn Lys Xaa Leu Gln Xaa Leu Ser Glu Xaa Tyr Phe Ile 
    130                 135                 140                 


Met Cys Ala Xaa Ala Glu Ala Gln Ser Xaa Leu Asn Cys Xaa Phe Xaa 
145                 150                 155                 160 


Ile Lys Leu Asn Asn Xaa Met Asn Ala Cys Ala Val Ile Ala Ala Leu 
                165                 170                 175     


Glu Arg Val Lys Ile Arg Pro Met Glu His Cys Cys Cys Ser Val Arg 
            180                 185                 190         


Ile Pro Cys Pro Ser Ser Pro Glu Glu Leu Glu Lys Leu Gln Cys Asp 
        195                 200                 205             


Leu Gln Asp Pro Ile Val Cys Leu Ala Asp His Pro Arg Gly Pro Pro 
    210                 215                 220                 


Phe Ser Ser Ser Gln Ser Ile Pro Val Val Pro Arg Ala Xaa Val Leu 
225                 230                 235                 240 


Ser Gln Val Pro Lys Ala Xaa Ser Phe Ala Glu Pro Pro Asp Tyr Ser 
                245                 250                 255     


Pro Val Xaa His Asn Val Pro Ser Pro Ile Gly Glu Ile Gln Pro Leu 
            260                 265                 270         


Ser Pro Gln Pro Ser Ala Pro Ile Ala Ser Ser Pro Ala Ile Asp Met 
        275                 280                 285             


Pro Pro Gln Ser Glu Xaa Ile Ser Ser Pro Met Pro Gln Xaa His Val 
    290                 295                 300                 


Ser Gly Xaa Pro Pro Pro Val Lys Ala Ser Phe Ser Ser Pro Xaa Val 
305                 310                 315                 320 


Ser Ala Pro Ala Asn Val Asn Xaa Xaa Ser Ala Pro Pro Val Gln Xaa 
                325                 330                 335     


Asp Ile Val Asn Xaa Ser Ser Ile Ser Asp Leu Glu Asn Gln Val Leu 
            340                 345                 350         


Gln Met Glu Lys Ala Leu Ser Leu Gly Ser Leu Glu Pro Asn Leu Ala 
        355                 360                 365             


Gly Glu Met Ile Asn Gln Val Ser Arg Leu Leu His Ser Pro Pro Asp 
    370                 375                 380                 


Met Leu Ala Pro Leu Ala Gln Arg Leu Leu Lys Val Val Asp Asp Ile 
385                 390                 395                 400 


Gly Leu Gln Leu Asn Phe Ser Asn Xaa Xaa Ile Ser Leu Xaa Ser Pro 
                405                 410                 415     


Ser Leu Ala Leu Ala Val Ile Arg Val Asn Ala Ser Ser Phe Asn Xaa 
            420                 425                 430         


Xaa Xaa Phe Val Ala Gln Asp Pro Ala Asn Leu Gln Val Ser Leu Glu 
        435                 440                 445             


Xaa Gln Ala Pro Glu Asn Ser Ile Gly Xaa Ile Xaa Leu Pro Ser Ser 
    450                 455                 460                 


Leu Met Asn Asn Leu Pro Ala His Asp Met Glu Leu Ala Ser Arg Val 
465                 470                 475                 480 


Gln Phe Asn Phe Phe Glu Xaa Pro Ala Leu Phe Gln Asp Pro Ser Leu 
                485                 490                 495     


Glu Asn Leu Ser Leu Ile Ser Tyr Val Ile Ser Ser Ser Val Ala Asn 
            500                 505                 510         


Leu Xaa Val Arg Asn Leu Xaa Arg Asn Val Xaa Val Xaa Leu Lys His 
        515                 520                 525             


Ile Asn Pro Ser Gln Asp Glu Leu Xaa Val Arg Cys Val Phe Trp Asp 
    530                 535                 540                 


Leu Gly Arg Asn Gly Gly Arg Gly Gly Trp Ser Asp Asn Gly Cys Ser 
545                 550                 555                 560 


Val Lys Asp Arg Arg Leu Asn Glu Xaa Ile Cys Xaa Cys Ser His Leu 
                565                 570                 575     


Xaa Ser Phe Gly Val Leu Leu Asp Leu Ser Arg Xaa Ser Val Leu Pro 
            580                 585                 590         


Ala Gln Met Met Ala Leu Xaa Phe Ile Xaa Tyr Ile Gly Cys Gly Leu 
        595                 600                 605             


Ser Ser Ile Phe Leu Ser Val Xaa Leu Val Xaa Tyr Ile Ala Phe Glu 
    610                 615                 620                 


Lys Ile Arg Arg Asp Tyr Pro Ser Lys Ile Leu Ile Gln Leu Cys Ala 
625                 630                 635                 640 


Ala Leu Leu Leu Leu Asn Leu Val Phe Leu Leu Asp Ser Trp Ile Ala 
                645                 650                 655     


Leu Tyr Lys Met Gln Gly Leu Cys Ile Ser Val Ala Val Phe Leu His 
            660                 665                 670         


Tyr Phe Leu Leu Val Ser Phe Xaa Trp Met Gly Leu Glu Ala Phe His 
        675                 680                 685             


Met Tyr Leu Ala Leu Val Lys Val Phe Asn Xaa Tyr Ile Arg Lys Tyr 
    690                 695                 700                 


Ile Leu Lys Phe Cys Ile Val Gly Trp Gly Val Pro Ala Val Val Val 
705                 710                 715                 720 


Xaa Ile Ile Leu Xaa Ile Ser Pro Asp Asn Tyr Gly Leu Gly Ser Tyr 
                725                 730                 735     


Gly Lys Phe Pro Asn Gly Ser Pro Asp Asp Phe Cys Trp Ile Asn Asn 
            740                 745                 750         


Asn Ala Val Phe Tyr Ile Xaa Val Val Gly Tyr Phe Cys Val Ile Phe 
        755                 760                 765             


Leu Leu Asn Val Ser Met Phe Ile Val Val Leu Val Gln Leu Cys Arg 
    770                 775                 780                 


Ile Lys Lys Lys Lys Gln Leu Gly Ala Gln Arg Lys Xaa Ser Ile Gln 
785                 790                 795                 800 


Asp Leu Arg Ser Ile Ala Gly Leu Xaa Phe Leu Leu Gly Ile Xaa Trp 
                805                 810                 815     


Gly Phe Ala Phe Phe Ala Trp Gly Pro Val Asn Val Xaa Phe Met Tyr 
            820                 825                 830         


Leu Phe Ala Ile Phe Asn Xaa Leu Gln Gly Phe Phe Ile Phe Ile Phe 
        835                 840                 845             


Tyr Cys Val Ala Lys Glu Asn Val Arg Lys Gln Trp Arg Arg Tyr Leu 
    850                 855                 860                 


Cys Cys Gly Lys Leu Arg Leu Ala Glu Asn Ser Asp Trp Ser Lys Xaa 
865                 870                 875                 880 


Ala Xaa Asn Gly Leu Lys Lys Gln Xaa Val Asn Gln Gly Val Ser Ser 
                885                 890                 895     


Ser Ser Asn Ser Leu Gln Ser Ser Ser Asn Ser Xaa Asn Ser Xaa Xaa 
            900                 905                 910         


Leu Leu Val Asn Asn Asp Cys Ser Val His Ala Ser Gly Asn Gly Asn 
        915                 920                 925             


Ala Ser Xaa Glu Arg Asn Gly Val Ser Phe Ser Val Gln Asn Gly Asp 
    930                 935                 940                 


Val Cys Leu His Asp Phe Xaa Gly Lys Gln His Met Phe Asn Glu Lys 
945                 950                 955                 960 


Glu Asp Ser Cys Asn Gly Lys Gly Arg Met Ala Leu Arg Arg Xaa Ser 
                965                 970                 975     


Lys Arg Gly Ser Leu His Phe Ile Glu Gln Met 
            980                 985         


<210> 1738
<211> 69
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 1738
Met Ala Xaa Pro Arg Gly Leu Gly Ala Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Pro Xaa Ser Gly Gln Glu Lys Pro Xaa Glu Gly Pro Arg Asn Xaa Cys 
            20                  25                  30          


Leu Gly Ser Asn Asn Met Tyr Asp Ile Phe Asn Leu Asn Asp Lys Ala 
        35                  40                  45              


Leu Cys Phe Xaa Lys Cys Arg Gln Ser Gly Ser Asp Ser Cys Asn Val 
    50                  55                  60                  


Glu Asn Leu Gln Arg 
65                  


<210> 1739
<211> 315
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<400> 1739
Met Ala Xaa Pro Arg Gly Leu Gly Ala Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Pro Xaa Ser Gly Gln Glu Lys Pro Xaa Glu Gly Pro Arg Asn Xaa Cys 
            20                  25                  30          


Leu Gly Ser Asn Asn Met Tyr Asp Ile Phe Asn Leu Asn Asp Lys Ala 
        35                  40                  45              


Leu Cys Phe Xaa Lys Cys Arg Gln Ser Gly Ser Asp Ser Cys Asn Val 
    50                  55                  60                  


Glu Asn Leu Gln Arg Tyr Trp Leu Asn Tyr Glu Ala His Leu Met Lys 
65                  70                  75                  80  


Glu Gly Leu Xaa Gln Lys Val Asn Xaa Pro Phe Leu Lys Ala Leu Val 
                85                  90                  95      


Gln Asn Leu Ser Xaa Asn Xaa Ala Glu Asp Phe Tyr Phe Ser Leu Glu 
            100                 105                 110         


Pro Ser Gln Val Pro Arg Gln Val Met Lys Asp Glu Asp Lys Pro Pro 
        115                 120                 125             


Asp Arg Val Arg Leu Pro Lys Ser Leu Phe Arg Ser Leu Pro Gly Asn 
    130                 135                 140                 


Arg Ser Val Val Arg Leu Ala Val Xaa Ile Leu Asp Ile Gly Pro Gly 
145                 150                 155                 160 


Xaa Leu Phe Lys Gly Pro Arg Leu Gly Leu Gly Asp Gly Ser Gly Val 
                165                 170                 175     


Leu Asn Asn Arg Leu Val Gly Leu Ser Val Gly Gln Met His Val Xaa 
            180                 185                 190         


Lys Leu Ala Glu Pro Leu Glu Ile Val Phe Ser His Gln Arg Pro Pro 
        195                 200                 205             


Pro Asn Met Xaa Leu Xaa Cys Val Phe Trp Asp Val Xaa Lys Gly Xaa 
    210                 215                 220                 


Xaa Gly Asp Trp Ser Ser Glu Gly Cys Ser Xaa Glu Val Arg Pro Glu 
225                 230                 235                 240 


Gly Xaa Val Cys Cys Cys Asp His Leu Xaa Phe Phe Ala Leu Leu Leu 
                245                 250                 255     


Arg Pro Xaa Leu Asp Gln Ser Xaa Val His Ile Leu Xaa Arg Ile Ser 
            260                 265                 270         


Gln Ala Gly Cys Gly Val Ser Met Ile Phe Leu Ala Phe Xaa Ile Ile 
        275                 280                 285             


Leu Tyr Ala Phe Leu Arg Pro Ala Arg Pro Asp Gly His Arg His Trp 
    290                 295                 300                 


Glu Cys Gln Gln Leu Arg Pro Leu His His Pro 
305                 310                 315 


<210> 1740
<211> 549
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<400> 1740
Met Ala Xaa Pro Arg Gly Leu Gly Ala Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Pro Xaa Ser Gly Gln Glu Lys Pro Xaa Glu Gly Pro Arg Asn Xaa Cys 
            20                  25                  30          


Leu Gly Ser Asn Asn Met Tyr Asp Ile Phe Asn Leu Asn Asp Lys Ala 
        35                  40                  45              


Leu Cys Phe Xaa Lys Cys Arg Gln Ser Gly Ser Asp Ser Cys Asn Val 
    50                  55                  60                  


Glu Asn Leu Gln Arg Tyr Trp Leu Asn Tyr Glu Ala His Leu Met Lys 
65                  70                  75                  80  


Glu Gly Leu Xaa Gln Lys Val Asn Xaa Pro Phe Leu Lys Ala Leu Val 
                85                  90                  95      


Gln Asn Leu Ser Xaa Asn Xaa Ala Glu Asp Phe Tyr Phe Ser Leu Glu 
            100                 105                 110         


Pro Ser Gln Val Pro Arg Gln Val Met Lys Asp Glu Asp Lys Pro Pro 
        115                 120                 125             


Asp Arg Val Arg Leu Pro Lys Ser Leu Phe Arg Ser Leu Pro Gly Asn 
    130                 135                 140                 


Arg Ser Val Val Arg Leu Ala Val Xaa Ile Leu Asp Ile Gly Pro Gly 
145                 150                 155                 160 


Xaa Leu Phe Lys Gly Pro Arg Leu Gly Leu Gly Asp Gly Ser Gly Val 
                165                 170                 175     


Leu Asn Asn Arg Leu Val Gly Leu Ser Val Gly Gln Met His Val Xaa 
            180                 185                 190         


Lys Leu Ala Glu Pro Leu Glu Ile Val Phe Ser His Gln Arg Pro Pro 
        195                 200                 205             


Pro Asn Met Xaa Leu Xaa Cys Val Phe Trp Asp Val Xaa Lys Gly Xaa 
    210                 215                 220                 


Xaa Gly Asp Trp Ser Ser Glu Gly Cys Ser Xaa Glu Val Arg Pro Glu 
225                 230                 235                 240 


Gly Xaa Val Cys Cys Cys Asp His Leu Xaa Phe Phe Ala Leu Leu Leu 
                245                 250                 255     


Arg Pro Xaa Leu Asp Gln Ser Xaa Val His Ile Leu Xaa Arg Ile Ser 
            260                 265                 270         


Gln Ala Gly Cys Gly Val Ser Met Ile Phe Leu Ala Phe Xaa Ile Ile 
        275                 280                 285             


Leu Tyr Ala Phe Leu Arg Leu Ser Arg Glu Arg Phe Lys Ser Glu Asp 
    290                 295                 300                 


Ala Pro Lys Ile His Val Ala Leu Gly Gly Ser Leu Phe Leu Leu Asn 
305                 310                 315                 320 


Leu Ala Phe Leu Val Asn Val Gly Ser Gly Ser Lys Gly Ser Asp Ala 
                325                 330                 335     


Ala Cys Trp Ala Arg Gly Ala Val Phe His Tyr Phe Leu Leu Cys Ala 
            340                 345                 350         


Phe Xaa Trp Met Gly Leu Glu Ala Phe His Leu Tyr Leu Leu Ala Val 
        355                 360                 365             


Arg Val Phe Asn Xaa Tyr Phe Gly His Tyr Phe Leu Lys Leu Ser Leu 
    370                 375                 380                 


Val Gly Trp Gly Leu Pro Ala Leu Met Val Ile Gly Xaa Gly Ser Ala 
385                 390                 395                 400 


Asn Ser Tyr Gly Leu Tyr Xaa Ile Arg Asp Arg Glu Asn Arg Xaa Ser 
                405                 410                 415     


Leu Glu Leu Cys Trp Phe Arg Glu Gly Xaa Xaa Met Tyr Ala Leu Tyr 
            420                 425                 430         


Ile Xaa Val His Gly Tyr Phe Leu Ile Xaa Phe Leu Phe Gly Met Val 
        435                 440                 445             


Val Leu Ala Leu Val Val Trp Lys Ile Phe Xaa Leu Ser Arg Ala Xaa 
    450                 455                 460                 


Ala Val Lys Glu Arg Gly Lys Asn Arg Lys Lys Val Leu Xaa Leu Leu 
465                 470                 475                 480 


Gly Leu Ser Ser Leu Val Gly Val Xaa Trp Gly Leu Ala Ile Phe Xaa 
                485                 490                 495     


Pro Leu Gly Leu Ser Xaa Val Tyr Ile Phe Ala Leu Phe Asn Ser Leu 
            500                 505                 510         


Gln Gly Val Phe Ile Cys Cys Trp Phe Xaa Ile Leu Tyr Leu Pro Ser 
        515                 520                 525             


Gln Ser Xaa Xaa Val Ser Ser Ser Xaa Ala Arg Leu Asp Gln Ala His 
    530                 535                 540                 


Ser Ala Ser Gln Glu 
545                 


<210> 1741
<211> 429
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<400> 1741
Met Lys Asp Glu Asp Lys Pro Pro Asp Arg Val Arg Leu Pro Lys Ser 
1               5                   10                  15      


Leu Phe Arg Ser Leu Pro Gly Asn Arg Ser Val Val Arg Leu Ala Val 
            20                  25                  30          


Xaa Ile Leu Asp Ile Gly Pro Gly Xaa Leu Phe Lys Gly Pro Arg Leu 
        35                  40                  45              


Gly Leu Gly Asp Gly Ser Gly Val Leu Asn Asn Arg Leu Val Gly Leu 
    50                  55                  60                  


Ser Val Gly Gln Met His Val Xaa Lys Leu Ala Glu Pro Leu Glu Ile 
65                  70                  75                  80  


Val Phe Ser His Gln Arg Pro Pro Pro Asn Met Xaa Leu Xaa Cys Val 
                85                  90                  95      


Phe Trp Asp Val Xaa Lys Gly Xaa Xaa Gly Asp Trp Ser Ser Glu Gly 
            100                 105                 110         


Cys Ser Xaa Glu Val Arg Pro Glu Gly Xaa Val Cys Cys Cys Asp His 
        115                 120                 125             


Leu Xaa Phe Phe Ala Leu Leu Leu Arg Pro Xaa Leu Asp Gln Ser Xaa 
    130                 135                 140                 


Val His Ile Leu Xaa Arg Ile Ser Gln Ala Gly Cys Gly Val Ser Met 
145                 150                 155                 160 


Ile Phe Leu Ala Phe Xaa Ile Ile Leu Tyr Ala Phe Leu Arg Leu Ser 
                165                 170                 175     


Arg Glu Arg Phe Lys Ser Glu Asp Ala Pro Lys Ile His Val Ala Leu 
            180                 185                 190         


Gly Gly Ser Leu Phe Leu Leu Asn Leu Ala Phe Leu Val Asn Val Gly 
        195                 200                 205             


Ser Gly Ser Lys Gly Ser Asp Ala Ala Cys Trp Ala Arg Gly Ala Val 
    210                 215                 220                 


Phe His Tyr Phe Leu Leu Cys Ala Phe Xaa Trp Met Gly Leu Glu Ala 
225                 230                 235                 240 


Phe His Leu Tyr Leu Leu Ala Val Arg Val Phe Asn Xaa Tyr Phe Gly 
                245                 250                 255     


His Tyr Phe Leu Lys Leu Ser Leu Val Gly Trp Gly Leu Pro Ala Leu 
            260                 265                 270         


Met Val Ile Gly Xaa Gly Ser Ala Asn Ser Tyr Gly Leu Tyr Xaa Ile 
        275                 280                 285             


Arg Asp Arg Glu Asn Arg Xaa Ser Leu Glu Leu Cys Trp Phe Arg Glu 
    290                 295                 300                 


Gly Xaa Xaa Met Tyr Ala Leu Tyr Ile Xaa Val His Gly Tyr Phe Leu 
305                 310                 315                 320 


Ile Xaa Phe Leu Phe Gly Met Val Val Leu Ala Leu Val Val Trp Lys 
                325                 330                 335     


Ile Phe Xaa Leu Ser Arg Ala Xaa Ala Val Lys Glu Arg Gly Lys Asn 
            340                 345                 350         


Arg Lys Lys Val Leu Xaa Leu Leu Gly Leu Ser Ser Leu Val Gly Val 
        355                 360                 365             


Xaa Trp Gly Leu Ala Ile Phe Xaa Pro Leu Gly Leu Ser Xaa Val Tyr 
    370                 375                 380                 


Ile Phe Ala Leu Phe Asn Ser Leu Gln Gly Val Phe Ile Cys Cys Trp 
385                 390                 395                 400 


Phe Xaa Ile Leu Tyr Leu Pro Ser Gln Ser Xaa Xaa Val Ser Ser Ser 
                405                 410                 415     


Xaa Ala Arg Leu Asp Gln Ala His Ser Ala Ser Gln Glu 
            420                 425                 


<210> 1742
<211> 3080
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (983)..(983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1007)..(1007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1107)..(1107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1131)..(1131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1190)..(1190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1213)..(1214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1224)..(1225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1262)..(1262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1268)..(1268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1291)..(1291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1297)..(1297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1299)..(1299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1304)..(1305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1322)..(1322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1340)..(1340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1342)..(1342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1344)..(1344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1363)..(1363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1383)..(1383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1393)..(1393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1413)..(1413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1418)..(1420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1424)..(1424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1444)..(1444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1449)..(1449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1459)..(1459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1461)..(1461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1470)..(1470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1479)..(1479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1486)..(1487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1496)..(1496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1508)..(1508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1521)..(1521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1524)..(1524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1531)..(1531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1537)..(1537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1553)..(1553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1576)..(1576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1581)..(1581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1583)..(1583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1590)..(1590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1599)..(1600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1602)..(1602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1605)..(1605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1611)..(1611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1619)..(1619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1630)..(1631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1641)..(1641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1643)..(1644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1649)..(1649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1652)..(1652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1658)..(1658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1661)..(1662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1669)..(1669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1674)..(1675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1685)..(1685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1694)..(1695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1703)..(1703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1713)..(1714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1722)..(1722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1728)..(1728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1733)..(1733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1738)..(1738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1745)..(1745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1772)..(1772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1781)..(1781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1786)..(1788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1795)..(1795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1799)..(1799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1805)..(1805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1808)..(1808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1812)..(1812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1816)..(1816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1824)..(1824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1829)..(1829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1834)..(1834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1843)..(1843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1849)..(1849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1852)..(1852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1857)..(1857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1868)..(1868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1871)..(1871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1875)..(1875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1881)..(1881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1887)..(1887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1897)..(1898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1903)..(1903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1909)..(1909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1911)..(1911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1921)..(1921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1923)..(1923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1927)..(1927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1959)..(1959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1965)..(1965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1967)..(1967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1974)..(1974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1979)..(1980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1983)..(1983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1986)..(1987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1996)..(1996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2008)..(2008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2022)..(2022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2031)..(2031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2034)..(2034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2041)..(2041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2044)..(2044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2054)..(2054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2057)..(2058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2063)..(2063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2066)..(2066)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2069)..(2069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2071)..(2071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2074)..(2074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2076)..(2076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2081)..(2082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2086)..(2086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2095)..(2095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2103)..(2103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2111)..(2112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2114)..(2114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2119)..(2119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2130)..(2130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2135)..(2136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2139)..(2139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2151)..(2151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2153)..(2153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2161)..(2161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2167)..(2167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2174)..(2174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2183)..(2185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2187)..(2187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2198)..(2198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2201)..(2201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2205)..(2205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2207)..(2207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2218)..(2219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2224)..(2224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2230)..(2230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2234)..(2234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2237)..(2237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2239)..(2239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2242)..(2242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2264)..(2264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2271)..(2271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2288)..(2288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2291)..(2291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2320)..(2320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2358)..(2358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2363)..(2363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2368)..(2368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2391)..(2391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2398)..(2398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2404)..(2404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2407)..(2407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2409)..(2409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2412)..(2412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2423)..(2423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2432)..(2432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2462)..(2462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2490)..(2490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2511)..(2511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2546)..(2546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2560)..(2560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2574)..(2574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2589)..(2589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2614)..(2614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2624)..(2624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2633)..(2633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2638)..(2638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2642)..(2642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2646)..(2647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2670)..(2670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2709)..(2709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2714)..(2714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2722)..(2722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2734)..(2734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2747)..(2747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2749)..(2749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2764)..(2764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2785)..(2785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2811)..(2811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2825)..(2825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2868)..(2868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2878)..(2878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2882)..(2883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2915)..(2915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2930)..(2930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2942)..(2942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2946)..(2946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2952)..(2952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2976)..(2976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3039)..(3039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3045)..(3045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3047)..(3047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3050)..(3050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3060)..(3060)
<223> Selenocysteine

<400> 1742
Met Lys Glu His Ile Ile Tyr Gln Lys Leu Tyr Gly Leu Ile Leu Met 
1               5                   10                  15      


Ser Ser Phe Ile Phe Leu Ser Asp Xaa Leu Ser Leu Lys Gly Lys Lys 
            20                  25                  30          


Leu Asp Phe Phe Gly Arg Gly Asp Xaa Tyr Val Ser Leu Ile Asp Xaa 
        35                  40                  45              


Ile Pro Glu Leu Ser Arg Phe Xaa Ala Cys Ile Asp Leu Val Phe Met 
    50                  55                  60                  


Asp Asp Asn Ser Arg Tyr Trp Met Ala Phe Ser Tyr Ile Xaa Asn Asn 
65                  70                  75                  80  


Ala Leu Leu Gly Arg Glu Asp Ile Asp Leu Gly Leu Ala Gly Asp His 
                85                  90                  95      


Gln Gln Leu Ile Leu Tyr Arg Leu Gly Lys Xaa Phe Ser Ile Arg His 
            100                 105                 110         


His Leu Ala Ser Phe Gln Trp His Xaa Ile Cys Leu Ile Trp Asp Gly 
        115                 120                 125             


Val Lys Gly Lys Leu Glu Leu Phe Leu Asn Lys Glu Arg Ile Leu Glu 
    130                 135                 140                 


Val Xaa Asp Gln Pro His Asn Leu Xaa Pro His Gly Xaa Leu Phe Leu 
145                 150                 155                 160 


Gly His Phe Leu Lys Asn Glu Ser Ser Glu Val Lys Ser Met Met Arg 
                165                 170                 175     


Ser Phe Pro Gly Ser Leu Tyr Tyr Phe Gln Leu Trp Asp His Ile Leu 
            180                 185                 190         


Glu Asn Glu Glu Phe Met Lys Cys Leu Asp Gly Asn Ile Val Ser Trp 
        195                 200                 205             


Glu Glu Asp Val Trp Leu Val Asn Lys Ile Ile Pro Xaa Val Asp Arg 
    210                 215                 220                 


Xaa Leu Arg Cys Phe Val Pro Glu Asn Met Xaa Ile Gln Glu Lys Ser 
225                 230                 235                 240 


Xaa Xaa Val Ser Gln Gln Ile Asp Met Xaa Xaa Pro Ser Gln Ile Xaa 
                245                 250                 255     


Gly Val Lys Pro Gln Asn Xaa Ala His Ser Ser Xaa Leu Leu Ser Gln 
            260                 265                 270         


Ser Ile Pro Ile Phe Ala Xaa Asp Tyr Xaa Xaa Ile Ser Tyr Ser Asn 
        275                 280                 285             


Xaa Xaa Ser Pro Pro Leu Glu Xaa Met Xaa Ala Gln Lys Ile Leu Lys 
    290                 295                 300                 


Xaa Leu Val Asp Glu Xaa Ala Xaa Phe Ala Val Asp Val Leu Ser Xaa 
305                 310                 315                 320 


Ser Ser Ala Ile Ser Leu Pro Xaa Gln Ser Ile Ser Ile Asp Asn Xaa 
                325                 330                 335     


Xaa Asn Ser Met Lys Lys Xaa Lys Ser Pro Ser Ser Glu Ser Xaa Lys 
            340                 345                 350         


Xaa Xaa Lys Met Val Glu Ala Met Ala Xaa Glu Ile Phe Gln Pro Pro 
        355                 360                 365             


Xaa Pro Ser Asn Phe Leu Ser Xaa Ser Arg Phe Xaa Lys Asn Ser Val 
    370                 375                 380                 


Val Ser Xaa Xaa Ser Ala Ile Lys Ser Gln Ser Ala Val Xaa Lys Xaa 
385                 390                 395                 400 


Xaa Ser Leu Phe Ser Xaa Ile Glu Ser Xaa Ser Met Ser Xaa Xaa Pro 
                405                 410                 415     


Cys Leu Lys Gln Lys Ser Xaa Asn Xaa Gly Ala Leu Pro Ile Ser Xaa 
            420                 425                 430         


Ala Gly Gln Glu Phe Ile Glu Ser Xaa Ala Ala Gly Xaa Val Pro Trp 
        435                 440                 445             


Phe Xaa Val Glu Lys Xaa Ser Pro Ala Ser Xaa His Val Gly Xaa Ala 
    450                 455                 460                 


Ser Ser Phe Pro Pro Glu Pro Val Leu Ile Ser Xaa Ala Ala Pro Val 
465                 470                 475                 480 


Asp Ser Val Phe Pro Arg Asn Gln Xaa Ala Phe Pro Leu Ala Xaa Xaa 
                485                 490                 495     


Asp Met Lys Ile Ala Phe Xaa Val His Ser Leu Xaa Leu Pro Xaa Arg 
            500                 505                 510         


Leu Ile Glu Xaa Xaa Pro Ala Pro Arg Xaa Ala Glu Xaa Glu Leu Xaa 
        515                 520                 525             


Ser Xaa Asn Phe Gln Asp Val Ser Leu Pro Arg Val Glu Asp Ala Met 
    530                 535                 540                 


Ser Xaa Ser Met Ser Lys Glu Xaa Ser Ser Lys Xaa Phe Ser Phe Leu 
545                 550                 555                 560 


Xaa Ser Phe Ser Phe Xaa Gly Xaa Glu Ser Val Gln Xaa Val Ile Asp 
                565                 570                 575     


Ala Glu Ala Xaa Arg Xaa Ala Leu Xaa Pro Glu Ile Xaa Leu Ala Ser 
            580                 585                 590         


Xaa Val Ala Glu Xaa Met Leu Ser Ser Xaa Ile Xaa Gly Arg Val Tyr 
        595                 600                 605             


Xaa Gln Asn Xaa Pro Xaa Ala Asp Gly His Leu Leu Xaa Leu Met Ser 
    610                 615                 620                 


Xaa Arg Ser Ala Ser Xaa Ser Lys Ala Pro Glu Ser Gly Pro Xaa Ser 
625                 630                 635                 640 


Xaa Xaa Asp Glu Ala Ala His Leu Phe Ser Ser Asn Glu Xaa Ile Trp 
                645                 650                 655     


Xaa Ser Arg Pro Asp Gln Ala Leu Leu Ala Ser Met Asn Xaa Xaa Xaa 
            660                 665                 670         


Ile Leu Xaa Phe Val Pro Asn Glu Asn Phe Xaa Ser Ala Phe His Glu 
        675                 680                 685             


Asn Xaa Xaa Tyr Xaa Glu Tyr Leu Ser Ala Xaa Xaa Asn Ile Xaa Pro 
    690                 695                 700                 


Leu Lys Ala Ser Pro Glu Gly Lys Gly Xaa Xaa Ala Asn Asp Ala Xaa 
705                 710                 715                 720 


Xaa Ala Arg Tyr Xaa Xaa Ala Val Ser Lys Leu Xaa Ser Pro Trp Phe 
                725                 730                 735     


Ala Asn Phe Ser Ile Val Ser Gly Xaa Xaa Ser Ile Xaa Asn Met Pro 
            740                 745                 750         


Glu Phe Lys Leu Xaa Xaa Leu Leu Leu Lys Xaa Ile Pro Met Ser Xaa 
        755                 760                 765             


Lys Pro Ala Asn Glu Leu Pro Leu Xaa Pro Arg Glu Xaa Val Val Pro 
    770                 775                 780                 


Ser Val Asp Ile Ile Ser Xaa Leu Ala Cys Ile Gln Pro Asn Phe Ser 
785                 790                 795                 800 


Xaa Glu Glu Ser Ala Ser Glu Xaa Xaa Gln Xaa Glu Ile Asn Gly Ala 
                805                 810                 815     


Ile Val Phe Gly Gly Xaa Xaa Xaa Pro Val Pro Lys Ser Ala Xaa Xaa 
            820                 825                 830         


Gln Arg Leu Asn Ala Xaa Val Xaa Arg Lys Glu Ala Xaa Ser His Tyr 
        835                 840                 845             


Leu Met Arg Lys Ser Xaa Ile Ala Ala Val Ala Glu Val Ser Pro Phe 
    850                 855                 860                 


Ser Xaa Met Leu Glu Val Xaa Asp Glu Ser Ala Gln Arg Val Xaa Ala 
865                 870                 875                 880 


Ser Val Xaa Val Ser Ser Phe Pro Asp Ile Glu Lys Leu Ser Xaa Pro 
                885                 890                 895     


Leu Asp Asn Lys Xaa Ala Xaa Xaa Glu Val Arg Glu Ser Trp Leu Leu 
            900                 905                 910         


Xaa Lys Leu Val Lys Xaa Xaa Pro Arg Ser Ser Tyr Asn Glu Met Xaa 
        915                 920                 925             


Glu Met Phe Asn Phe Asn His Xaa Tyr Val Ala His Trp Xaa Ser Glu 
    930                 935                 940                 


Xaa Ser Glu Gly Ile Ser Ala Gly Ser Pro Xaa Ser Gly Ser Xaa His 
945                 950                 955                 960 


Ile Phe Gly Glu Pro Leu Gly Ala Ser Xaa Xaa Arg Ile Ser Glu Xaa 
                965                 970                 975     


Ser Phe Ser Xaa Xaa Pro Xaa Asp Arg Xaa Ala Xaa Ser Leu Ser Asp 
            980                 985                 990         


Gly Ile Leu Pro Pro Gln Pro Xaa  Ala Ala His Ser Ser  Ala Xaa Pro 
        995                 1000                 1005             


Val Pro  Val Xaa His Met Phe  Ser Leu Pro Val Asn  Gly Ser Ser 
    1010                 1015                 1020             


Val Val  Ala Glu Glu Xaa Glu  Val Xaa Met Ser Glu  Pro Ser Xaa 
    1025                 1030                 1035             


Leu Ala  Arg Ala Phe Ser Xaa  Ser Val Leu Ser Asp  Val Ser Asn 
    1040                 1045                 1050             


Leu Ser  Ser Xaa Xaa Met Xaa  Xaa Ala Leu Val Pro  Pro Leu Asp 
    1055                 1060                 1065             


Gln Xaa  Ala Ser Xaa Xaa Ile  Val Ile Val Pro Xaa  His Gly Asp 
    1070                 1075                 1080             


Leu Ile  Arg Xaa Xaa Ser Glu  Ala Xaa Val Ile Ser  Val Arg Lys 
    1085                 1090                 1095             


Xaa Ser  Met Ala Val Pro Ser  Leu Xaa Glu Xaa Pro  Phe His Ser 
    1100                 1105                 1110             


Leu Arg  Leu Ser Xaa Pro Val  Xaa Ala Lys Ala Glu  Xaa Xaa Leu 
    1115                 1120                 1125             


Phe Ser  Xaa Ser Val Asp Xaa  Val Xaa Pro Ser Xaa  His Xaa Leu 
    1130                 1135                 1140             


Val Cys  Ser Lys Pro Pro Pro  Asp Asn Ile Pro Pro  Ala Ser Ser 
    1145                 1150                 1155             


Xaa His  Val Ile Ser Xaa Xaa  Ser Xaa Pro Glu Ala  Xaa Gln Pro 
    1160                 1165                 1170             


Ile Ser  Gln Val Glu Glu Xaa  Ser Xaa Tyr Ala Leu  Ser Phe Pro 
    1175                 1180                 1185             


Tyr Xaa  Phe Ser Gly Gly Gly  Val Val Ala Ser Leu  Ala Xaa Gly 
    1190                 1195                 1200             


Xaa Xaa  Glu Xaa Ser Val Val  Asp Glu Xaa Xaa Pro  Ser His Ile 
    1205                 1210                 1215             


Ser Ala  Asn Lys Leu Xaa Xaa  Ser Val Asn Ser His  Ile Ser Ser 
    1220                 1225                 1230             


Ser Ala  Xaa Tyr Arg Val His  Xaa Pro Val Ser Ile  Gln Leu Val 
    1235                 1240                 1245             


Xaa Ser  Xaa Ser Val Leu Ser  Ser Asp Lys Asp Gln  Met Xaa Ile 
    1250                 1255                 1260             


Ser Leu  Gly Lys Xaa Pro Arg  Xaa Met Glu Val Xaa  Glu Met Ser 
    1265                 1270                 1275             


Pro Ser  Lys Asn Ser Phe Ile  Ser Tyr Ser Arg Gly  Xaa Pro Ser 
    1280                 1285                 1290             


Leu Glu  Met Xaa Asp Xaa Gly  Phe Pro Glu Xaa Xaa  Lys Ile Ser 
    1295                 1300                 1305             


Ser His  Gln Xaa His Ser Pro  Ser Glu Ile Pro Leu  Gly Xaa Pro 
    1310                 1315                 1320             


Ser Asp  Gly Asn Leu Ala Ser  Ser Pro Xaa Ser Gly  Ser Xaa Gln 
    1325                 1330                 1335             


Ile Xaa  Pro Xaa Leu Xaa Ser  Ser Asn Xaa Val Gly  Val His Ile 
    1340                 1345                 1350             


Pro Glu  Met Ser Xaa Ser Leu  Gly Lys Xaa Ala Leu  Pro Ser Gln 
    1355                 1360                 1365             


Ala Leu  Xaa Ile Xaa Xaa Phe  Leu Cys Pro Glu Lys  Glu Ser Xaa 
    1370                 1375                 1380             


Ser Ala  Leu Pro Ala Tyr Xaa  Pro Arg Xaa Val Glu  Met Ile Val 
    1385                 1390                 1395             


Asn Ser  Xaa Tyr Val Xaa His  Ser Val Ser Tyr Gly  Gln Asp Xaa 
    1400                 1405                 1410             


Ser Phe  Val Asp Xaa Xaa Xaa  Ser Ser Ser Xaa Arg  Ile Ser Asn 
    1415                 1420                 1425             


Pro Met  Asp Ile Asn Xaa Xaa  Phe Ser His Leu His  Ser Leu Arg 
    1430                 1435                 1440             


Xaa Gln  Pro Glu Val Xaa Ser  Val Ala Ser Phe Ile  Ser Glu Ser 
    1445                 1450                 1455             


Xaa Gln  Xaa Phe Pro Glu Ser  Leu Ser Leu Ser Xaa  Ala Gly Leu 
    1460                 1465                 1470             


Tyr Asn  Asp Gly Phe Xaa Val  Leu Ser Asp Arg Ile  Xaa Xaa Ala 
    1475                 1480                 1485             


Phe Ser  Val Pro Asn Val Pro  Xaa Met Leu Pro Arg  Glu Ser Ser 
    1490                 1495                 1500             


Met Ala  Xaa Ser Xaa Pro Ile  Tyr Gln Met Ser Ser  Leu Pro Val 
    1505                 1510                 1515             


Asn Val  Xaa Ala Phe Xaa Ser  Lys Lys Val Ser Asp  Xaa Pro Pro 
    1520                 1525                 1530             


Ile Val  Ile Xaa Lys Ser Ser  Lys Xaa Met His Pro  Gly Cys Leu 
    1535                 1540                 1545             


Lys Ser  Pro Cys Xaa Ala Xaa  Ser Gly Pro Met Ser  Glu Met Ser 
    1550                 1555                 1560             


Ser Ile  Pro Val Asn Asn Ser  Ala Phe Xaa Pro Ala  Xaa Val Ser 
    1565                 1570                 1575             


Ser Asp  Xaa Ser Xaa Arg Val  Gly Leu Phe Ser Xaa  Leu Leu Ser 
    1580                 1585                 1590             


Ser Val  Xaa Pro Arg Xaa Xaa  Met Xaa Met Gln Xaa  Ser Xaa Leu 
    1595                 1600                 1605             


Asp Val  Xaa Pro Val Ile Tyr  Ala Gly Ala Xaa Ser  Lys Asn Lys 
    1610                 1615                 1620             


Met Val  Ser Ser Ala Phe Xaa  Xaa Glu Met Ile Glu  Ala Pro Ser 
    1625                 1630                 1635             


Arg Ile  Xaa Pro Xaa Xaa Phe  Leu Ser Pro Xaa Glu  Pro Xaa Leu 
    1640                 1645                 1650             


Pro Phe  Val Lys Xaa Val Pro  Xaa Xaa Ile Met Ala  Gly Ile Val 
    1655                 1660                 1665             


Xaa Pro  Phe Val Gly Xaa Xaa  Ala Phe Ser Pro Leu  Ser Ser Lys 
    1670                 1675                 1680             


Ser Xaa  Gly Ala Ile Ser Ser  Ile Pro Lys Xaa Xaa  Phe Ser Pro 
    1685                 1690                 1695             


Phe Leu  Ser Ala Xaa Gln Gln  Ser Ser Gln Ala Asp  Glu Ala Xaa 
    1700                 1705                 1710             


Xaa Leu  Gly Ile Leu Ser Gly  Ile Xaa Asn Arg Ser  Leu Ser Xaa 
    1715                 1720                 1725             


Val Asn  Ser Gly Xaa Gly Val  Ala Leu Xaa Asp Xaa  Tyr Ser Arg 
    1730                 1735                 1740             


Ile Xaa  Val Pro Glu Asn Met  Leu Ser Pro Xaa His  Ala Asp Ser 
    1745                 1750                 1755             


Leu His  Xaa Ser Phe Asn Ile  Gln Val Ser Pro Ser  Leu Xaa Ser 
    1760                 1765                 1770             


Phe Lys  Ser Ala Ser Gly Pro  Xaa Lys Asn Val Lys  Xaa Xaa Xaa 
    1775                 1780                 1785             


Asn Cys  Phe Ser Ser Asn Xaa  Arg Lys Met Xaa Ser  Leu Leu Glu 
    1790                 1795                 1800             


Lys Xaa  Ser Leu Xaa Asn Tyr  Ala Xaa Ser Leu Asn  Xaa Pro Val 
    1805                 1810                 1815             


Ser Tyr  Pro Pro Trp Xaa Pro  Ser Ser Ala Xaa Leu  Pro Ser Leu 
    1820                 1825                 1830             


Xaa Ser  Phe Val Tyr Ser Pro  His Ser Xaa Glu Ala  Glu Ile Ser 
    1835                 1840                 1845             


Xaa Pro  Lys Xaa Ser Pro Pro  Pro Xaa Ser Gln Met  Val Glu Phe 
    1850                 1855                 1860             


Pro Val  Leu Gly Xaa Arg Met  Xaa Ser Ser Asn Xaa  Gln Pro Leu 
    1865                 1870                 1875             


Leu Met  Xaa Ser Trp Asn Ile  Pro Xaa Ala Glu Gly  Ser Gln Phe 
    1880                 1885                 1890             


Pro Ile  Ser Xaa Xaa Ile Asn  Val Pro Xaa Ser Asn  Glu Met Glu 
    1895                 1900                 1905             


Xaa Glu  Xaa Leu His Leu Val  Pro Gly Pro Leu Ser  Xaa Phe Xaa 
    1910                 1915                 1920             


Ala Ser  Gln Xaa Gly Leu Val  Ser Lys Asp Val Met  Ala Met Ser 
    1925                 1930                 1935             


Ser Ile  Pro Met Ser Gly Ile  Leu Pro Asn His Gly  Leu Ser Glu 
    1940                 1945                 1950             


Asn Pro  Ser Leu Ser Xaa Ser  Leu Arg Ala Ile Xaa  Ser Xaa Leu 
    1955                 1960                 1965             


Ala Asp  Val Lys His Xaa Phe  Glu Lys Met Xaa Xaa  Ser Val Xaa 
    1970                 1975                 1980             


Pro Gly  Xaa Xaa Leu Pro Ser  Ile Leu Ser Gly Ala  Xaa Ser Gly 
    1985                 1990                 1995             


Ser Val  Ile Ser Lys Ser Pro  Ile Leu Xaa Trp Leu  Leu Ser Ser 
    2000                 2005                 2010             


Leu Pro  Ser Gly Ser Pro Pro  Ala Xaa Val Ser Asn  Ala Pro His 
    2015                 2020                 2025             


Val Met  Xaa Ser Ser Xaa Val  Glu Val Ser Lys Ser  Xaa Phe Leu 
    2030                 2035                 2040             


Xaa Ser  Asp Met Ile Ser Ala  His Pro Phe Xaa Asn  Leu Xaa Xaa 
    2045                 2050                 2055             


Leu Pro  Ser Ala Xaa Met Ser  Xaa Ile Leu Xaa Arg  Xaa Ile Pro 
    2060                 2065                 2070             


Xaa Pro  Xaa Leu Gly Gly Ile  Xaa Xaa Gly Phe Pro  Xaa Ser Leu 
    2075                 2080                 2085             


Pro Met  Ser Ile Asn Val Xaa  Asp Asp Ile Val Tyr  Ile Ser Xaa 
    2090                 2095                 2100             


His Pro  Glu Ala Ser Ser Arg  Xaa Xaa Ile Xaa Ala  Asn Pro Arg 
    2105                 2110                 2115             


Xaa Val  Ser His Pro Ser Ser  Phe Ser Arg Lys Xaa  Met Ser Pro 
    2120                 2125                 2130             


Ser Xaa  Xaa Asp His Xaa Leu  Ser Val Gly Ala Met  Pro Leu Pro 
    2135                 2140                 2145             


Ser Ser  Xaa Ile Xaa Ser Ser  Trp Asn Arg Ile Pro  Xaa Ala Ser 
    2150                 2155                 2160             


Ser Pro  Ser Xaa Leu Ile Ile  Pro Lys Pro Xaa Leu  Asp Ser Leu 
    2165                 2170                 2175             


Leu Asn  Ile Met Xaa Xaa Xaa  Ser Xaa Val Pro Gly  Ala Ser Phe 
    2180                 2185                 2190             


Pro Leu  Ile Ser Xaa Gly Val  Xaa Tyr Pro Phe Xaa  Ala Xaa Val 
    2195                 2200                 2205             


Ser Ser  Pro Ile Ser Ser Phe  Phe Glu Xaa Xaa Trp  Leu Asp Ser 
    2210                 2215                 2220             


Xaa Pro  Ser Phe Leu Ser Xaa  Glu Ala Ser Xaa Ser  Pro Xaa Ala 
    2225                 2230                 2235             


Xaa Lys  Ser Xaa Val Ser Phe  Tyr Asn Val Glu Met  Ser Phe Ser 
    2240                 2245                 2250             


Val Phe  Val Glu Glu Pro Arg  Ile Pro Ile Xaa Ser  Val Ile Asn 
    2255                 2260                 2265             


Glu Phe  Xaa Glu Asn Ser Leu  Asn Ser Ile Phe Gln  Asn Ser Glu 
    2270                 2275                 2280             


Phe Ser  Leu Ala Xaa Leu Glu  Xaa Gln Ile Lys Ser  Arg Asp Ile 
    2285                 2290                 2295             


Ser Glu  Glu Glu Met Val Met  Asp Arg Ala Ile Leu  Glu Gln Arg 
    2300                 2305                 2310             


Glu Gly  Gln Glu Met Ala Xaa  Ile Ser Tyr Val Pro  Tyr Ser Cys 
    2315                 2320                 2325             


Val Cys  Gln Val Ile Ile Lys  Ala Ser Ser Ser Leu  Ala Ser Ser 
    2330                 2335                 2340             


Glu Leu  Met Arg Lys Ile Lys  Ser Lys Ile His Gly  Asn Phe Xaa 
    2345                 2350                 2355             


His Gly  Asn Phe Xaa Gln Asp  Gln Leu Xaa Leu Leu  Val Asn Cys 
    2360                 2365                 2370             


Glu His  Val Ala Val Lys Lys  Leu Glu Pro Gly Asn  Cys Lys Ala 
    2375                 2380                 2385             


Asp Glu  Xaa Ala Ser Lys Tyr  Lys Gly Xaa Tyr Lys  Trp Leu Leu 
    2390                 2395                 2400             


Xaa Asn  Pro Xaa Glu Xaa Ala  Gln Xaa Arg Cys Ile  Lys Asn Glu 
    2405                 2410                 2415             


Asp Gly  Asn Ala Xaa Arg Phe  Cys Ser Ile Ser Ile  Asn Xaa Gly 
    2420                 2425                 2430             


Lys Ser  Gln Trp Glu Lys Pro  Lys Phe Lys Gln Cys  Lys Leu Leu 
    2435                 2440                 2445             


Gln Glu  Leu Pro Asp Lys Ile  Val Asp Leu Ala Asn  Ile Xaa Ile 
    2450                 2455                 2460             


Ser Asp  Glu Asn Ala Glu Asp  Val Ala Glu His Ile  Leu Asn Leu 
    2465                 2470                 2475             


Ile Asn  Glu Ser Pro Ala Leu  Gly Lys Glu Glu Xaa  Lys Ile Ile 
    2480                 2485                 2490             


Val Ser  Lys Ile Ser Asp Ile  Ser Gln Cys Asp Glu  Ile Ser Met 
    2495                 2500                 2505             


Asn Leu  Xaa His Val Met Leu  Gln Ile Ile Asn Val  Val Leu Glu 
    2510                 2515                 2520             


Lys Gln  Asn Asn Ser Ala Ser  Asp Leu His Glu Ile  Ser Asn Glu 
    2525                 2530                 2535             


Ile Leu  Arg Ile Ile Glu Arg  Xaa Gly His Lys Met  Glu Phe Ser 
    2540                 2545                 2550             


Gly Gln  Ile Ala Asn Leu Xaa  Val Ala Gly Leu Ala  Leu Ala Val 
    2555                 2560                 2565             


Leu Arg  Gly Asp His Xaa Phe  Asp Gly Met Ala Phe  Ser Ile His 
    2570                 2575                 2580             


Ser Tyr  Glu Glu Gly Xaa Asp  Pro Glu Ile Phe Leu  Gly Asn Val 
    2585                 2590                 2595             


Pro Val  Gly Gly Ile Leu Ala  Ser Ile Tyr Leu Pro  Lys Ser Leu 
    2600                 2605                 2610             


Xaa Glu  Arg Ile Pro Leu Ser  Asn Leu Gln Xaa Ile  Leu Phe Asn 
    2615                 2620                 2625             


Phe Phe  Gly Gln Xaa Ser Leu  Phe Lys Xaa Lys Asn  Val Xaa Lys 
    2630                 2635                 2640             


Ala Leu  Xaa Xaa Tyr Val Val  Ser Ala Ser Ile Ser  Asp Asp Met 
    2645                 2650                 2655             


Phe Ile  Gln Asn Leu Ala Asp  Pro Val Val Ile Xaa  Leu Gln His 
    2660                 2665                 2670             


Ile Gly  Gly Asn Gln Asn Tyr  Gly Gln Val His Cys  Ala Phe Trp 
    2675                 2680                 2685             


Asp Phe  Glu Asn Asn Asn Gly  Leu Gly Gly Trp Asn  Ser Ser Gly 
    2690                 2695                 2700             


Cys Lys  Val Lys Glu Xaa Asn  Val Asn Tyr Xaa Ile  Cys Gln Cys 
    2705                 2710                 2715             


Asp His  Leu Xaa His Phe Gly  Val Leu Met Asp Leu  Ser Arg Ser 
    2720                 2725                 2730             


Xaa Val  Asp Ser Val Asn Glu  Gln Ile Leu Ala Leu  Ile Xaa Tyr 
    2735                 2740                 2745             


Xaa Gly  Cys Gly Ile Ser Ser  Ile Phe Leu Gly Val  Ala Val Val 
    2750                 2755                 2760             


Xaa Tyr  Ile Ala Phe His Lys  Leu Arg Lys Asp Tyr  Pro Ala Lys 
    2765                 2770                 2775             


Ile Leu  Ile Asn Leu Cys Xaa  Ala Leu Leu Met Leu  Asn Leu Val 
    2780                 2785                 2790             


Phe Leu  Ile Asn Ser Trp Leu  Ser Ser Phe Gln Lys  Val Gly Val 
    2795                 2800                 2805             


Cys Ile  Xaa Ala Ala Val Ala  Leu His Tyr Phe Leu  Leu Val Ser 
    2810                 2815                 2820             


Phe Xaa  Trp Met Gly Leu Glu  Ala Val His Met Tyr  Leu Ala Leu 
    2825                 2830                 2835             


Val Lys  Val Phe Asn Ile Tyr  Ile Pro Asn Tyr Ile  Leu Lys Phe 
    2840                 2845                 2850             


Cys Leu  Val Gly Trp Gly Ile  Pro Ala Ile Met Val  Ala Ile Xaa 
    2855                 2860                 2865             


Val Ser  Val Lys Lys Asp Leu  Tyr Gly Xaa Leu Ser  Pro Xaa Xaa 
    2870                 2875                 2880             


Pro Phe  Cys Trp Ile Lys Asp  Asp Ser Ile Phe Tyr  Ile Ser Val 
    2885                 2890                 2895             


Val Ala  Tyr Phe Cys Leu Ile  Phe Leu Met Asn Leu  Ser Met Phe 
    2900                 2905                 2910             


Cys Xaa  Val Leu Val Gln Leu  Asn Ser Val Lys Ser  Gln Ile Gln 
    2915                 2920                 2925             


Lys Xaa  Arg Arg Lys Met Ile  Leu His Asp Leu Lys  Gly Xaa Met 
    2930                 2935                 2940             


Ser Leu  Xaa Phe Leu Leu Gly  Leu Xaa Trp Gly Phe  Ala Phe Phe 
    2945                 2950                 2955             


Ala Trp  Gly Pro Met Arg Asn  Phe Phe Leu Tyr Leu  Phe Ala Ile 
    2960                 2965                 2970             


Phe Asn  Xaa Leu Gln Gly Phe  Phe Ile Phe Val Phe  His Cys Val 
    2975                 2980                 2985             


Met Lys  Glu Ser Val Arg Glu  Gln Trp Gln Ile His  Leu Cys Cys 
    2990                 2995                 3000             


Gly Trp  Leu Arg Leu Asp Asn  Ser Ser Asp Gly Ser  Ser Arg Cys 
    3005                 3010                 3015             


Gln Ile  Lys Val Gly Tyr Lys  Gln Glu Gly Leu Lys  Lys Ile Phe 
    3020                 3025                 3030             


Glu His  Lys Leu Leu Xaa Pro  Ser Leu Lys Ser Xaa  Ala Xaa Ser 
    3035                 3040                 3045             


Ser Xaa  Phe Lys Ser Leu Gly  Ser Ala Gln Gly Xaa  Pro Ser Glu 
    3050                 3055                 3060             


Ile Ser  Phe Pro Asn Asp Asp  Phe Asp Lys Asp Pro  Tyr Cys Ser 
    3065                 3070                 3075             


Ser Pro  
    3080 


<210> 1743
<211> 2875
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1066)..(1066)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1107)..(1107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1117)..(1117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1128)..(1128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1208)..(1208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1213)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1244)..(1244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1281)..(1282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1291)..(1291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1316)..(1316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1319)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1368)..(1368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1378)..(1378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1391)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1394)..(1395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1397)..(1397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1400)..(1400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1402)..(1402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1406)..(1406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1425)..(1426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1436)..(1436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1438)..(1439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1444)..(1444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1447)..(1447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1453)..(1453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1456)..(1457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1464)..(1464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1469)..(1470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1480)..(1480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1489)..(1490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1498)..(1498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1508)..(1509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1517)..(1517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1523)..(1523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1528)..(1528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1533)..(1533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1535)..(1535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1540)..(1540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1549)..(1549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1556)..(1556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1567)..(1567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1576)..(1576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1581)..(1583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1590)..(1590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1600)..(1600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1603)..(1603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1611)..(1611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1619)..(1619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1624)..(1624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1629)..(1629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1638)..(1638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1644)..(1644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1647)..(1647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1652)..(1652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1663)..(1663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1666)..(1666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1670)..(1670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1676)..(1676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1682)..(1682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1692)..(1693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1698)..(1698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1704)..(1704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1706)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1716)..(1716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1718)..(1718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1722)..(1722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1762)..(1762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1769)..(1769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1774)..(1775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1778)..(1778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1781)..(1782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1791)..(1791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1803)..(1803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1817)..(1817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1826)..(1826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1829)..(1829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1836)..(1836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1839)..(1839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1849)..(1849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1852)..(1853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1858)..(1858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1861)..(1861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1864)..(1864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1866)..(1866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1869)..(1869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1871)..(1871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1876)..(1877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1881)..(1881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1890)..(1890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1898)..(1898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1906)..(1907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1909)..(1909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1914)..(1914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1925)..(1925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1930)..(1931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1934)..(1934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1946)..(1946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1948)..(1948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1956)..(1956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1962)..(1962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1969)..(1969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1978)..(1980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1982)..(1982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1993)..(1993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1996)..(1996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2000)..(2000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2002)..(2002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2013)..(2014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2019)..(2019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2025)..(2025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2029)..(2029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2032)..(2032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2034)..(2034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2037)..(2037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2059)..(2059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2066)..(2066)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2083)..(2083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2086)..(2086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2115)..(2115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2153)..(2153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2158)..(2158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2163)..(2163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2186)..(2186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2193)..(2193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2199)..(2199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2202)..(2202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2204)..(2204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2207)..(2207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2218)..(2218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2227)..(2227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2257)..(2257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2285)..(2285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2306)..(2306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2341)..(2341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2355)..(2355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2369)..(2369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2384)..(2384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2409)..(2409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2419)..(2419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2428)..(2428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2433)..(2433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2437)..(2437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2441)..(2442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2465)..(2465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2504)..(2504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2509)..(2509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2517)..(2517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2529)..(2529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2542)..(2542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2544)..(2544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2559)..(2559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2580)..(2580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2606)..(2606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2620)..(2620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2663)..(2663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2673)..(2673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2677)..(2678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2710)..(2710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2725)..(2725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2737)..(2737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2741)..(2741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2747)..(2747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2771)..(2771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2834)..(2834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2840)..(2840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2842)..(2842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2845)..(2845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2855)..(2855)
<223> Selenocysteine

<400> 1743
Met Lys Glu His Ile Ile Tyr Gln Lys Leu Tyr Gly Leu Ile Leu Met 
1               5                   10                  15      


Ser Ser Phe Ile Phe Leu Ser Val Val Pro Glu Asn Met Xaa Ile Gln 
            20                  25                  30          


Glu Lys Ser Xaa Xaa Val Ser Gln Gln Ile Asp Met Xaa Xaa Pro Ser 
        35                  40                  45              


Gln Ile Xaa Gly Val Lys Pro Gln Asn Xaa Ala His Ser Ser Xaa Leu 
    50                  55                  60                  


Leu Ser Gln Ser Ile Pro Ile Phe Ala Xaa Asp Tyr Xaa Xaa Ile Ser 
65                  70                  75                  80  


Tyr Ser Asn Xaa Xaa Ser Pro Pro Leu Glu Xaa Met Xaa Ala Gln Lys 
                85                  90                  95      


Ile Leu Lys Xaa Leu Val Asp Glu Xaa Ala Xaa Phe Ala Val Asp Val 
            100                 105                 110         


Leu Ser Xaa Ser Ser Ala Ile Ser Leu Pro Xaa Gln Ser Ile Ser Ile 
        115                 120                 125             


Asp Asn Xaa Xaa Asn Ser Met Lys Lys Xaa Lys Ser Pro Ser Ser Glu 
    130                 135                 140                 


Ser Xaa Lys Xaa Xaa Lys Met Val Glu Ala Met Ala Xaa Glu Ile Phe 
145                 150                 155                 160 


Gln Pro Pro Xaa Pro Ser Asn Phe Leu Ser Xaa Ser Arg Phe Xaa Lys 
                165                 170                 175     


Asn Ser Val Val Ser Xaa Xaa Ser Ala Ile Lys Ser Gln Ser Ala Val 
            180                 185                 190         


Xaa Lys Xaa Xaa Ser Leu Phe Ser Xaa Ile Glu Ser Xaa Ser Met Ser 
        195                 200                 205             


Xaa Xaa Pro Cys Leu Lys Gln Lys Ser Xaa Asn Xaa Gly Ala Leu Pro 
    210                 215                 220                 


Ile Ser Xaa Ala Gly Gln Glu Phe Ile Glu Ser Xaa Ala Ala Gly Xaa 
225                 230                 235                 240 


Val Pro Trp Phe Xaa Val Glu Lys Xaa Ser Pro Ala Ser Xaa His Val 
                245                 250                 255     


Gly Xaa Ala Ser Ser Phe Pro Pro Glu Pro Val Leu Ile Ser Xaa Ala 
            260                 265                 270         


Ala Pro Val Asp Ser Val Phe Pro Arg Asn Gln Xaa Ala Phe Pro Leu 
        275                 280                 285             


Ala Xaa Xaa Asp Met Lys Ile Ala Phe Xaa Val His Ser Leu Xaa Leu 
    290                 295                 300                 


Pro Xaa Arg Leu Ile Glu Xaa Xaa Pro Ala Pro Arg Xaa Ala Glu Xaa 
305                 310                 315                 320 


Glu Leu Xaa Ser Xaa Asn Phe Gln Asp Val Ser Leu Pro Arg Val Glu 
                325                 330                 335     


Asp Ala Met Ser Xaa Ser Met Ser Lys Glu Xaa Ser Ser Lys Xaa Phe 
            340                 345                 350         


Ser Phe Leu Xaa Ser Phe Ser Phe Xaa Gly Xaa Glu Ser Val Gln Xaa 
        355                 360                 365             


Val Ile Asp Ala Glu Ala Xaa Arg Xaa Ala Leu Xaa Pro Glu Ile Xaa 
    370                 375                 380                 


Leu Ala Ser Xaa Val Ala Glu Xaa Met Leu Ser Ser Xaa Ile Xaa Gly 
385                 390                 395                 400 


Arg Val Tyr Xaa Gln Asn Xaa Pro Xaa Ala Asp Gly His Leu Leu Xaa 
                405                 410                 415     


Leu Met Ser Xaa Arg Ser Ala Ser Xaa Ser Lys Ala Pro Glu Ser Gly 
            420                 425                 430         


Pro Xaa Ser Xaa Xaa Asp Glu Ala Ala His Leu Phe Ser Ser Asn Glu 
        435                 440                 445             


Xaa Ile Trp Xaa Ser Arg Pro Asp Gln Ala Leu Leu Ala Ser Met Asn 
    450                 455                 460                 


Xaa Xaa Xaa Ile Leu Xaa Phe Val Pro Asn Glu Asn Phe Xaa Ser Ala 
465                 470                 475                 480 


Phe His Glu Asn Xaa Xaa Tyr Xaa Glu Tyr Leu Ser Ala Xaa Xaa Asn 
                485                 490                 495     


Ile Xaa Pro Leu Lys Ala Ser Pro Glu Gly Lys Gly Xaa Xaa Ala Asn 
            500                 505                 510         


Asp Ala Xaa Xaa Ala Arg Tyr Xaa Xaa Ala Val Ser Lys Leu Xaa Ser 
        515                 520                 525             


Pro Trp Phe Ala Asn Phe Ser Ile Val Ser Gly Xaa Xaa Ser Ile Xaa 
    530                 535                 540                 


Asn Met Pro Glu Phe Lys Leu Xaa Xaa Leu Leu Leu Lys Xaa Ile Pro 
545                 550                 555                 560 


Met Ser Xaa Lys Pro Ala Asn Glu Leu Pro Leu Xaa Pro Arg Glu Xaa 
                565                 570                 575     


Val Val Pro Ser Val Asp Ile Ile Ser Xaa Leu Ala Cys Ile Gln Pro 
            580                 585                 590         


Asn Phe Ser Xaa Glu Glu Ser Ala Ser Glu Xaa Xaa Gln Xaa Glu Ile 
        595                 600                 605             


Asn Gly Ala Ile Val Phe Gly Gly Xaa Xaa Xaa Pro Val Pro Lys Ser 
    610                 615                 620                 


Ala Xaa Xaa Gln Arg Leu Asn Ala Xaa Val Xaa Arg Lys Glu Ala Xaa 
625                 630                 635                 640 


Ser His Tyr Leu Met Arg Lys Ser Xaa Ile Ala Ala Val Ala Glu Val 
                645                 650                 655     


Ser Pro Phe Ser Xaa Met Leu Glu Val Xaa Asp Glu Ser Ala Gln Arg 
            660                 665                 670         


Val Xaa Ala Ser Val Xaa Val Ser Ser Phe Pro Asp Ile Glu Lys Leu 
        675                 680                 685             


Ser Xaa Pro Leu Asp Asn Lys Xaa Ala Xaa Xaa Glu Val Arg Glu Ser 
    690                 695                 700                 


Trp Leu Leu Xaa Lys Leu Val Lys Xaa Xaa Pro Arg Ser Ser Tyr Asn 
705                 710                 715                 720 


Glu Met Xaa Glu Met Phe Asn Phe Asn His Xaa Tyr Val Ala His Trp 
                725                 730                 735     


Xaa Ser Glu Xaa Ser Glu Gly Ile Ser Ala Gly Ser Pro Xaa Ser Gly 
            740                 745                 750         


Ser Xaa His Ile Phe Gly Glu Pro Leu Gly Ala Ser Xaa Xaa Arg Ile 
        755                 760                 765             


Ser Glu Xaa Ser Phe Ser Xaa Xaa Pro Xaa Asp Arg Xaa Ala Xaa Ser 
    770                 775                 780                 


Leu Ser Asp Gly Ile Leu Pro Pro Gln Pro Xaa Ala Ala His Ser Ser 
785                 790                 795                 800 


Ala Xaa Pro Val Pro Val Xaa His Met Phe Ser Leu Pro Val Asn Gly 
                805                 810                 815     


Ser Ser Val Val Ala Glu Glu Xaa Glu Val Xaa Met Ser Glu Pro Ser 
            820                 825                 830         


Xaa Leu Ala Arg Ala Phe Ser Xaa Ser Val Leu Ser Asp Val Ser Asn 
        835                 840                 845             


Leu Ser Ser Xaa Xaa Met Xaa Xaa Ala Leu Val Pro Pro Leu Asp Gln 
    850                 855                 860                 


Xaa Ala Ser Xaa Xaa Ile Val Ile Val Pro Xaa His Gly Asp Leu Ile 
865                 870                 875                 880 


Arg Xaa Xaa Ser Glu Ala Xaa Val Ile Ser Val Arg Lys Xaa Ser Met 
                885                 890                 895     


Ala Val Pro Ser Leu Xaa Glu Xaa Pro Phe His Ser Leu Arg Leu Ser 
            900                 905                 910         


Xaa Pro Val Xaa Ala Lys Ala Glu Xaa Xaa Leu Phe Ser Xaa Ser Val 
        915                 920                 925             


Asp Xaa Val Xaa Pro Ser Xaa His Xaa Leu Val Cys Ser Lys Pro Pro 
    930                 935                 940                 


Pro Asp Asn Ile Pro Pro Ala Ser Ser Xaa His Val Ile Ser Xaa Xaa 
945                 950                 955                 960 


Ser Xaa Pro Glu Ala Xaa Gln Pro Ile Ser Gln Val Glu Glu Xaa Ser 
                965                 970                 975     


Xaa Tyr Ala Leu Ser Phe Pro Tyr Xaa Phe Ser Gly Gly Gly Val Val 
            980                 985                 990         


Ala Ser Leu Ala Xaa Gly Xaa Xaa  Glu Xaa Ser Val Val  Asp Glu Xaa 
        995                 1000                 1005             


Xaa Pro  Ser His Ile Ser Ala  Asn Lys Leu Xaa Xaa  Ser Val Asn 
    1010                 1015                 1020             


Ser His  Ile Ser Ser Ser Ala  Xaa Tyr Arg Val His  Xaa Pro Val 
    1025                 1030                 1035             


Ser Ile  Gln Leu Val Xaa Ser  Xaa Ser Val Leu Ser  Ser Asp Lys 
    1040                 1045                 1050             


Asp Gln  Met Xaa Ile Ser Leu  Gly Lys Xaa Pro Arg  Xaa Met Glu 
    1055                 1060                 1065             


Val Xaa  Glu Met Ser Pro Ser  Lys Asn Ser Phe Ile  Ser Tyr Ser 
    1070                 1075                 1080             


Arg Gly  Xaa Pro Ser Leu Glu  Met Xaa Asp Xaa Gly  Phe Pro Glu 
    1085                 1090                 1095             


Xaa Xaa  Lys Ile Ser Ser His  Gln Xaa His Ser Pro  Ser Glu Ile 
    1100                 1105                 1110             


Pro Leu  Gly Xaa Pro Ser Asp  Gly Asn Leu Ala Ser  Ser Pro Xaa 
    1115                 1120                 1125             


Ser Gly  Ser Xaa Gln Ile Xaa  Pro Xaa Leu Xaa Ser  Ser Asn Xaa 
    1130                 1135                 1140             


Val Gly  Val His Ile Pro Glu  Met Ser Xaa Ser Leu  Gly Lys Xaa 
    1145                 1150                 1155             


Ala Leu  Pro Ser Gln Ala Leu  Xaa Ile Xaa Xaa Phe  Leu Cys Pro 
    1160                 1165                 1170             


Glu Lys  Glu Ser Xaa Ser Ala  Leu Pro Ala Tyr Xaa  Pro Arg Xaa 
    1175                 1180                 1185             


Val Glu  Met Ile Val Asn Ser  Xaa Tyr Val Xaa His  Ser Val Ser 
    1190                 1195                 1200             


Tyr Gly  Gln Asp Xaa Ser Phe  Val Asp Xaa Xaa Xaa  Ser Ser Ser 
    1205                 1210                 1215             


Xaa Arg  Ile Ser Asn Pro Met  Asp Ile Asn Xaa Xaa  Phe Ser His 
    1220                 1225                 1230             


Leu His  Ser Leu Arg Xaa Gln  Pro Glu Val Xaa Ser  Val Ala Ser 
    1235                 1240                 1245             


Phe Ile  Ser Glu Ser Xaa Gln  Xaa Phe Pro Glu Ser  Leu Ser Leu 
    1250                 1255                 1260             


Ser Xaa  Ala Gly Leu Tyr Asn  Asp Gly Phe Xaa Val  Leu Ser Asp 
    1265                 1270                 1275             


Arg Ile  Xaa Xaa Ala Phe Ser  Val Pro Asn Val Pro  Xaa Met Leu 
    1280                 1285                 1290             


Pro Arg  Glu Ser Ser Met Ala  Xaa Ser Xaa Pro Ile  Tyr Gln Met 
    1295                 1300                 1305             


Ser Ser  Leu Pro Val Asn Val  Xaa Ala Phe Xaa Ser  Lys Lys Val 
    1310                 1315                 1320             


Ser Asp  Xaa Pro Pro Ile Val  Ile Xaa Lys Ser Ser  Lys Xaa Met 
    1325                 1330                 1335             


His Pro  Gly Cys Leu Lys Ser  Pro Cys Xaa Ala Xaa  Ser Gly Pro 
    1340                 1345                 1350             


Met Ser  Glu Met Ser Ser Ile  Pro Val Asn Asn Ser  Ala Phe Xaa 
    1355                 1360                 1365             


Pro Ala  Xaa Val Ser Ser Asp  Xaa Ser Xaa Arg Val  Gly Leu Phe 
    1370                 1375                 1380             


Ser Xaa  Leu Leu Ser Ser Val  Xaa Pro Arg Xaa Xaa  Met Xaa Met 
    1385                 1390                 1395             


Gln Xaa  Ser Xaa Leu Asp Val  Xaa Pro Val Ile Tyr  Ala Gly Ala 
    1400                 1405                 1410             


Xaa Ser  Lys Asn Lys Met Val  Ser Ser Ala Phe Xaa  Xaa Glu Met 
    1415                 1420                 1425             


Ile Glu  Ala Pro Ser Arg Ile  Xaa Pro Xaa Xaa Phe  Leu Ser Pro 
    1430                 1435                 1440             


Xaa Glu  Pro Xaa Leu Pro Phe  Val Lys Xaa Val Pro  Xaa Xaa Ile 
    1445                 1450                 1455             


Met Ala  Gly Ile Val Xaa Pro  Phe Val Gly Xaa Xaa  Ala Phe Ser 
    1460                 1465                 1470             


Pro Leu  Ser Ser Lys Ser Xaa  Gly Ala Ile Ser Ser  Ile Pro Lys 
    1475                 1480                 1485             


Xaa Xaa  Phe Ser Pro Phe Leu  Ser Ala Xaa Gln Gln  Ser Ser Gln 
    1490                 1495                 1500             


Ala Asp  Glu Ala Xaa Xaa Leu  Gly Ile Leu Ser Gly  Ile Xaa Asn 
    1505                 1510                 1515             


Arg Ser  Leu Ser Xaa Val Asn  Ser Gly Xaa Gly Val  Ala Leu Xaa 
    1520                 1525                 1530             


Asp Xaa  Tyr Ser Arg Ile Xaa  Val Pro Glu Asn Met  Leu Ser Pro 
    1535                 1540                 1545             


Xaa His  Ala Asp Ser Leu His  Xaa Ser Phe Asn Ile  Gln Val Ser 
    1550                 1555                 1560             


Pro Ser  Leu Xaa Ser Phe Lys  Ser Ala Ser Gly Pro  Xaa Lys Asn 
    1565                 1570                 1575             


Val Lys  Xaa Xaa Xaa Asn Cys  Phe Ser Ser Asn Xaa  Arg Lys Met 
    1580                 1585                 1590             


Xaa Ser  Leu Leu Glu Lys Xaa  Ser Leu Xaa Asn Tyr  Ala Xaa Ser 
    1595                 1600                 1605             


Leu Asn  Xaa Pro Val Ser Tyr  Pro Pro Trp Xaa Pro  Ser Ser Ala 
    1610                 1615                 1620             


Xaa Leu  Pro Ser Leu Xaa Ser  Phe Val Tyr Ser Pro  His Ser Xaa 
    1625                 1630                 1635             


Glu Ala  Glu Ile Ser Xaa Pro  Lys Xaa Ser Pro Pro  Pro Xaa Ser 
    1640                 1645                 1650             


Gln Met  Val Glu Phe Pro Val  Leu Gly Xaa Arg Met  Xaa Ser Ser 
    1655                 1660                 1665             


Asn Xaa  Gln Pro Leu Leu Met  Xaa Ser Trp Asn Ile  Pro Xaa Ala 
    1670                 1675                 1680             


Glu Gly  Ser Gln Phe Pro Ile  Ser Xaa Xaa Ile Asn  Val Pro Xaa 
    1685                 1690                 1695             


Ser Asn  Glu Met Glu Xaa Glu  Xaa Leu His Leu Val  Pro Gly Pro 
    1700                 1705                 1710             


Leu Ser  Xaa Phe Xaa Ala Ser  Gln Xaa Gly Leu Val  Ser Lys Asp 
    1715                 1720                 1725             


Val Met  Ala Met Ser Ser Ile  Pro Met Ser Gly Ile  Leu Pro Asn 
    1730                 1735                 1740             


His Gly  Leu Ser Glu Asn Pro  Ser Leu Ser Xaa Ser  Leu Arg Ala 
    1745                 1750                 1755             


Ile Xaa  Ser Xaa Leu Ala Asp  Val Lys His Xaa Phe  Glu Lys Met 
    1760                 1765                 1770             


Xaa Xaa  Ser Val Xaa Pro Gly  Xaa Xaa Leu Pro Ser  Ile Leu Ser 
    1775                 1780                 1785             


Gly Ala  Xaa Ser Gly Ser Val  Ile Ser Lys Ser Pro  Ile Leu Xaa 
    1790                 1795                 1800             


Trp Leu  Leu Ser Ser Leu Pro  Ser Gly Ser Pro Pro  Ala Xaa Val 
    1805                 1810                 1815             


Ser Asn  Ala Pro His Val Met  Xaa Ser Ser Xaa Val  Glu Val Ser 
    1820                 1825                 1830             


Lys Ser  Xaa Phe Leu Xaa Ser  Asp Met Ile Ser Ala  His Pro Phe 
    1835                 1840                 1845             


Xaa Asn  Leu Xaa Xaa Leu Pro  Ser Ala Xaa Met Ser  Xaa Ile Leu 
    1850                 1855                 1860             


Xaa Arg  Xaa Ile Pro Xaa Pro  Xaa Leu Gly Gly Ile  Xaa Xaa Gly 
    1865                 1870                 1875             


Phe Pro  Xaa Ser Leu Pro Met  Ser Ile Asn Val Xaa  Asp Asp Ile 
    1880                 1885                 1890             


Val Tyr  Ile Ser Xaa His Pro  Glu Ala Ser Ser Arg  Xaa Xaa Ile 
    1895                 1900                 1905             


Xaa Ala  Asn Pro Arg Xaa Val  Ser His Pro Ser Ser  Phe Ser Arg 
    1910                 1915                 1920             


Lys Xaa  Met Ser Pro Ser Xaa  Xaa Asp His Xaa Leu  Ser Val Gly 
    1925                 1930                 1935             


Ala Met  Pro Leu Pro Ser Ser  Xaa Ile Xaa Ser Ser  Trp Asn Arg 
    1940                 1945                 1950             


Ile Pro  Xaa Ala Ser Ser Pro  Ser Xaa Leu Ile Ile  Pro Lys Pro 
    1955                 1960                 1965             


Xaa Leu  Asp Ser Leu Leu Asn  Ile Met Xaa Xaa Xaa  Ser Xaa Val 
    1970                 1975                 1980             


Pro Gly  Ala Ser Phe Pro Leu  Ile Ser Xaa Gly Val  Xaa Tyr Pro 
    1985                 1990                 1995             


Phe Xaa  Ala Xaa Val Ser Ser  Pro Ile Ser Ser Phe  Phe Glu Xaa 
    2000                 2005                 2010             


Xaa Trp  Leu Asp Ser Xaa Pro  Ser Phe Leu Ser Xaa  Glu Ala Ser 
    2015                 2020                 2025             


Xaa Ser  Pro Xaa Ala Xaa Lys  Ser Xaa Val Ser Phe  Tyr Asn Val 
    2030                 2035                 2040             


Glu Met  Ser Phe Ser Val Phe  Val Glu Glu Pro Arg  Ile Pro Ile 
    2045                 2050                 2055             


Xaa Ser  Val Ile Asn Glu Phe  Xaa Glu Asn Ser Leu  Asn Ser Ile 
    2060                 2065                 2070             


Phe Gln  Asn Ser Glu Phe Ser  Leu Ala Xaa Leu Glu  Xaa Gln Ile 
    2075                 2080                 2085             


Lys Ser  Arg Asp Ile Ser Glu  Glu Glu Met Val Met  Asp Arg Ala 
    2090                 2095                 2100             


Ile Leu  Glu Gln Arg Glu Gly  Gln Glu Met Ala Xaa  Ile Ser Tyr 
    2105                 2110                 2115             


Val Pro  Tyr Ser Cys Val Cys  Gln Val Ile Ile Lys  Ala Ser Ser 
    2120                 2125                 2130             


Ser Leu  Ala Ser Ser Glu Leu  Met Arg Lys Ile Lys  Ser Lys Ile 
    2135                 2140                 2145             


His Gly  Asn Phe Xaa His Gly  Asn Phe Xaa Gln Asp  Gln Leu Xaa 
    2150                 2155                 2160             


Leu Leu  Val Asn Cys Glu His  Val Ala Val Lys Lys  Leu Glu Pro 
    2165                 2170                 2175             


Gly Asn  Cys Lys Ala Asp Glu  Xaa Ala Ser Lys Tyr  Lys Gly Xaa 
    2180                 2185                 2190             


Tyr Lys  Trp Leu Leu Xaa Asn  Pro Xaa Glu Xaa Ala  Gln Xaa Arg 
    2195                 2200                 2205             


Cys Ile  Lys Asn Glu Asp Gly  Asn Ala Xaa Arg Phe  Cys Ser Ile 
    2210                 2215                 2220             


Ser Ile  Asn Xaa Gly Lys Ser  Gln Trp Glu Lys Pro  Lys Phe Lys 
    2225                 2230                 2235             


Gln Cys  Lys Leu Leu Gln Glu  Leu Pro Asp Lys Ile  Val Asp Leu 
    2240                 2245                 2250             


Ala Asn  Ile Xaa Ile Ser Asp  Glu Asn Ala Glu Asp  Val Ala Glu 
    2255                 2260                 2265             


His Ile  Leu Asn Leu Ile Asn  Glu Ser Pro Ala Leu  Gly Lys Glu 
    2270                 2275                 2280             


Glu Xaa  Lys Ile Ile Val Ser  Lys Ile Ser Asp Ile  Ser Gln Cys 
    2285                 2290                 2295             


Asp Glu  Ile Ser Met Asn Leu  Xaa His Val Met Leu  Gln Ile Ile 
    2300                 2305                 2310             


Asn Val  Val Leu Glu Lys Gln  Asn Asn Ser Ala Ser  Asp Leu His 
    2315                 2320                 2325             


Glu Ile  Ser Asn Glu Ile Leu  Arg Ile Ile Glu Arg  Xaa Gly His 
    2330                 2335                 2340             


Lys Met  Glu Phe Ser Gly Gln  Ile Ala Asn Leu Xaa  Val Ala Gly 
    2345                 2350                 2355             


Leu Ala  Leu Ala Val Leu Arg  Gly Asp His Xaa Phe  Asp Gly Met 
    2360                 2365                 2370             


Ala Phe  Ser Ile His Ser Tyr  Glu Glu Gly Xaa Asp  Pro Glu Ile 
    2375                 2380                 2385             


Phe Leu  Gly Asn Val Pro Val  Gly Gly Ile Leu Ala  Ser Ile Tyr 
    2390                 2395                 2400             


Leu Pro  Lys Ser Leu Xaa Glu  Arg Ile Pro Leu Ser  Asn Leu Gln 
    2405                 2410                 2415             


Xaa Ile  Leu Phe Asn Phe Phe  Gly Gln Xaa Ser Leu  Phe Lys Xaa 
    2420                 2425                 2430             


Lys Asn  Val Xaa Lys Ala Leu  Xaa Xaa Tyr Val Val  Ser Ala Ser 
    2435                 2440                 2445             


Ile Ser  Asp Asp Met Phe Ile  Gln Asn Leu Ala Asp  Pro Val Val 
    2450                 2455                 2460             


Ile Xaa  Leu Gln His Ile Gly  Gly Asn Gln Asn Tyr  Gly Gln Val 
    2465                 2470                 2475             


His Cys  Ala Phe Trp Asp Phe  Glu Asn Asn Asn Gly  Leu Gly Gly 
    2480                 2485                 2490             


Trp Asn  Ser Ser Gly Cys Lys  Val Lys Glu Xaa Asn  Val Asn Tyr 
    2495                 2500                 2505             


Xaa Ile  Cys Gln Cys Asp His  Leu Xaa His Phe Gly  Val Leu Met 
    2510                 2515                 2520             


Asp Leu  Ser Arg Ser Xaa Val  Asp Ser Val Asn Glu  Gln Ile Leu 
    2525                 2530                 2535             


Ala Leu  Ile Xaa Tyr Xaa Gly  Cys Gly Ile Ser Ser  Ile Phe Leu 
    2540                 2545                 2550             


Gly Val  Ala Val Val Xaa Tyr  Ile Ala Phe His Lys  Leu Arg Lys 
    2555                 2560                 2565             


Asp Tyr  Pro Ala Lys Ile Leu  Ile Asn Leu Cys Xaa  Ala Leu Leu 
    2570                 2575                 2580             


Met Leu  Asn Leu Val Phe Leu  Ile Asn Ser Trp Leu  Ser Ser Phe 
    2585                 2590                 2595             


Gln Lys  Val Gly Val Cys Ile  Xaa Ala Ala Val Ala  Leu His Tyr 
    2600                 2605                 2610             


Phe Leu  Leu Val Ser Phe Xaa  Trp Met Gly Leu Glu  Ala Val His 
    2615                 2620                 2625             


Met Tyr  Leu Ala Leu Val Lys  Val Phe Asn Ile Tyr  Ile Pro Asn 
    2630                 2635                 2640             


Tyr Ile  Leu Lys Phe Cys Leu  Val Gly Trp Gly Ile  Pro Ala Ile 
    2645                 2650                 2655             


Met Val  Ala Ile Xaa Val Ser  Val Lys Lys Asp Leu  Tyr Gly Xaa 
    2660                 2665                 2670             


Leu Ser  Pro Xaa Xaa Pro Phe  Cys Trp Ile Lys Asp  Asp Ser Ile 
    2675                 2680                 2685             


Phe Tyr  Ile Ser Val Val Ala  Tyr Phe Cys Leu Ile  Phe Leu Met 
    2690                 2695                 2700             


Asn Leu  Ser Met Phe Cys Xaa  Val Leu Val Gln Leu  Asn Ser Val 
    2705                 2710                 2715             


Lys Ser  Gln Ile Gln Lys Xaa  Arg Arg Lys Met Ile  Leu His Asp 
    2720                 2725                 2730             


Leu Lys  Gly Xaa Met Ser Leu  Xaa Phe Leu Leu Gly  Leu Xaa Trp 
    2735                 2740                 2745             


Gly Phe  Ala Phe Phe Ala Trp  Gly Pro Met Arg Asn  Phe Phe Leu 
    2750                 2755                 2760             


Tyr Leu  Phe Ala Ile Phe Asn  Xaa Leu Gln Gly Phe  Phe Ile Phe 
    2765                 2770                 2775             


Val Phe  His Cys Val Met Lys  Glu Ser Val Arg Glu  Gln Trp Gln 
    2780                 2785                 2790             


Ile His  Leu Cys Cys Gly Trp  Leu Arg Leu Asp Asn  Ser Ser Asp 
    2795                 2800                 2805             


Gly Ser  Ser Arg Cys Gln Ile  Lys Val Gly Tyr Lys  Gln Glu Gly 
    2810                 2815                 2820             


Leu Lys  Lys Ile Phe Glu His  Lys Leu Leu Xaa Pro  Ser Leu Lys 
    2825                 2830                 2835             


Ser Xaa  Ala Xaa Ser Ser Xaa  Phe Lys Ser Leu Gly  Ser Ala Gln 
    2840                 2845                 2850             


Gly Xaa  Pro Ser Glu Ile Ser  Phe Pro Asn Asp Asp  Phe Asp Lys 
    2855                 2860                 2865             


Asp Pro  Tyr Cys Ser Ser Pro  
    2870                 2875 


<210> 1744
<211> 528
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(527)
<223> Selenocysteine

<400> 1744
Met Asp His Cys Gly Ala Leu Phe Leu Cys Leu Cys Leu Leu Xaa Leu 
1               5                   10                  15      


Gln Asn Ala Xaa Xaa Glu Xaa Trp Glu Glu Leu Leu Ser Tyr Met Glu 
            20                  25                  30          


Asn Met Gln Val Ser Arg Gly Arg Ser Ser Val Phe Ser Ser Arg Gln 
        35                  40                  45              


Leu His Gln Leu Glu Gln Met Leu Leu Asn Xaa Ser Phe Pro Gly Tyr 
    50                  55                  60                  


Asn Leu Xaa Leu Gln Xaa Pro Xaa Ile Gln Ser Leu Ala Phe Lys Leu 
65                  70                  75                  80  


Ser Cys Asp Phe Ser Gly Leu Ser Leu Xaa Ser Ala Xaa Leu Lys Arg 
                85                  90                  95      


Val Pro Gln Ala Gly Gly Gln His Ala Arg Gly Gln His Ala Met Gln 
            100                 105                 110         


Phe Pro Ala Glu Leu Xaa Arg Asp Ala Cys Lys Xaa Arg Pro Arg Glu 
        115                 120                 125             


Leu Arg Leu Ile Cys Ile Tyr Phe Ser Asn Xaa His Phe Phe Lys Asp 
    130                 135                 140                 


Glu Asn Asn Ser Ser Leu Leu Asn Asn Tyr Val Leu Gly Ala Gln Leu 
145                 150                 155                 160 


Ser His Gly His Val Asn Asn Leu Arg Asp Pro Val Asn Ile Ser Phe 
                165                 170                 175     


Trp His Asn Gln Ser Leu Glu Gly Tyr Xaa Leu Xaa Cys Val Phe Trp 
            180                 185                 190         


Lys Glu Gly Ala Arg Lys Gln Pro Trp Gly Gly Trp Ser Pro Glu Gly 
        195                 200                 205             


Cys Arg Xaa Glu Gln Pro Ser His Ser Gln Val Leu Cys Arg Cys Asn 
    210                 215                 220                 


His Leu Xaa Tyr Phe Ala Val Leu Met Gln Leu Ser Pro Ala Leu Val 
225                 230                 235                 240 


Pro Ala Glu Leu Leu Ala Pro Leu Xaa Tyr Ile Ser Leu Val Gly Cys 
                245                 250                 255     


Ser Ile Ser Ile Val Ala Ser Leu Ile Xaa Val Leu Leu His Phe His 
            260                 265                 270         


Phe Arg Lys Gln Ser Asp Ser Leu Xaa Arg Ile His Met Asn Leu His 
        275                 280                 285             


Ala Ser Val Leu Leu Leu Asn Ile Ala Phe Leu Leu Ser Pro Ala Phe 
    290                 295                 300                 


Ala Met Ser Pro Val Pro Gly Ser Ala Cys Xaa Ala Leu Ala Ala Ala 
305                 310                 315                 320 


Leu His Tyr Ala Leu Leu Ser Cys Leu Xaa Trp Met Ala Ile Glu Gly 
                325                 330                 335     


Phe Asn Leu Tyr Leu Leu Leu Gly Arg Val Tyr Asn Ile Tyr Ile Arg 
            340                 345                 350         


Arg Tyr Val Phe Lys Leu Gly Val Leu Gly Trp Gly Ala Pro Ala Leu 
        355                 360                 365             


Leu Val Leu Leu Ser Leu Ser Val Lys Ser Ser Val Tyr Gly Pro Cys 
    370                 375                 380                 


Xaa Ile Pro Val Phe Asp Ser Trp Glu Asn Gly Xaa Gly Phe Gln Asn 
385                 390                 395                 400 


Met Ser Ile Cys Trp Val Arg Ser Pro Val Val His Ser Val Leu Val 
                405                 410                 415     


Met Gly Tyr Gly Gly Leu Xaa Ser Leu Phe Asn Leu Val Val Leu Ala 
            420                 425                 430         


Trp Ala Leu Trp Xaa Leu Arg Arg Leu Arg Glu Arg Ala Asp Ala Pro 
        435                 440                 445             


Ser Val Arg Ala Cys His Asp Xaa Val Xaa Val Leu Gly Leu Xaa Val 
    450                 455                 460                 


Leu Leu Gly Xaa Xaa Trp Ala Leu Ala Phe Phe Ser Phe Gly Val Phe 
465                 470                 475                 480 


Leu Leu Pro Gln Leu Phe Leu Phe Xaa Ile Leu Asn Ser Leu Tyr Gly 
                485                 490                 495     


Phe Phe Leu Phe Leu Trp Phe Cys Ser Gln Arg Cys Arg Ser Glu Ala 
            500                 505                 510         


Glu Ala Lys Ala Gln Ile Glu Ala Phe Ser Ser Ser Gln Xaa Xaa Gln 
        515                 520                 525             


<210> 1745
<211> 221
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<400> 1745
Met Asp His Cys Gly Ala Leu Phe Leu Cys Leu Cys Leu Leu Xaa Leu 
1               5                   10                  15      


Gln Asn Ala Xaa Xaa Glu Xaa Trp Glu Glu Leu Leu Ser Tyr Met Glu 
            20                  25                  30          


Asn Met Gln Val Ser Arg Gly Arg Ser Ser Val Phe Ser Ser Arg Gln 
        35                  40                  45              


Leu His Gln Leu Glu Gln Met Leu Leu Asn Xaa Ser Phe Pro Gly Tyr 
    50                  55                  60                  


Asn Leu Xaa Leu Gln Xaa Pro Xaa Ile Gln Ser Leu Ala Phe Lys Leu 
65                  70                  75                  80  


Ser Cys Asp Phe Ser Gly Leu Ser Leu Xaa Ser Ala Xaa Leu Lys Arg 
                85                  90                  95      


Val Pro Gln Ala Gly Gly Gln His Ala Arg Gly Gln His Ala Met Gln 
            100                 105                 110         


Phe Pro Ala Glu Leu Xaa Arg Asp Ala Cys Lys Xaa Arg Pro Arg Glu 
        115                 120                 125             


Leu Arg Leu Ile Cys Ile Tyr Phe Ser Asn Xaa His Phe Phe Lys Asp 
    130                 135                 140                 


Glu Asn Asn Ser Ser Leu Leu Asn Asn Tyr Val Leu Gly Ala Gln Leu 
145                 150                 155                 160 


Ser His Gly His Val Asn Asn Leu Arg Asp Pro Val Asn Ile Ser Phe 
                165                 170                 175     


Trp His Asn Gln Ser Leu Val Leu Leu Gly Ala Pro Pro Phe Pro Leu 
            180                 185                 190         


His Pro Cys Pro Ser Val Xaa Leu Leu Leu Asn Xaa Gly Leu Xaa Arg 
        195                 200                 205             


Pro Lys Pro Val Glu Pro Ser Trp Lys Ser Ile Xaa Leu 
    210                 215                 220     


<210> 1746
<211> 141
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<400> 1746
Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys Pro 
1               5                   10                  15      


Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro His 
            20                  25                  30          


Ser Ala Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro 
        35                  40                  45              


Ser Gly Xaa Phe Xaa Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser 
    50                  55                  60                  


Gln Ala Cys Met Trp Xaa Leu Arg Ala Pro Xaa Gly Tyr Ile Ile Gln 
65                  70                  75                  80  


Ile Xaa Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr 
                85                  90                  95      


Asp Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Xaa Lys Phe Cys Gly 
            100                 105                 110         


Ala Xaa Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His 
        115                 120                 125             


Val Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly 
    130                 135                 140     


<210> 1747
<211> 241
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<400> 1747
Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys Pro 
1               5                   10                  15      


Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro His 
            20                  25                  30          


Ser Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro Ser 
        35                  40                  45              


Gly Xaa Phe Xaa Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser Gln 
    50                  55                  60                  


Ala Cys Met Trp Xaa Leu Arg Ala Pro Xaa Gly Tyr Ile Ile Gln Ile 
65                  70                  75                  80  


Xaa Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr Asp 
                85                  90                  95      


Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Xaa Lys Phe Cys Gly Ala 
            100                 105                 110         


Xaa Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His Val 
        115                 120                 125             


Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly Phe Asn Ala Ser 
    130                 135                 140                 


Tyr Ile Arg Val Ala Val Ser Leu Arg Asn Gln Lys Val Ile Leu Pro 
145                 150                 155                 160 


Gln Xaa Ser Asp Ala Tyr Gln Val Ser Val Ala Lys Ser Ile Ser Ile 
                165                 170                 175     


Pro Glu Leu Ser Ala Phe Xaa Leu Cys Phe Glu Ala Xaa Lys Val Gly 
            180                 185                 190         


His Glu Asp Ser Asp Trp Xaa Ala Phe Ser Tyr Ser Asn Ala Ser Phe 
        195                 200                 205             


Xaa Gln Leu Leu Ser Phe Gly Lys Ala Lys Ser Gly Tyr Phe Leu Ser 
    210                 215                 220                 


Ile Ser Asp Ser Lys Cys Leu Leu Asn Asn Ala Leu Pro Val Lys Glu 
225                 230                 235                 240 


Lys 
    


<210> 1748
<211> 1193
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (996)..(996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1117)..(1117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1190)..(1190)
<223> Selenocysteine

<400> 1748
Met Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys 
1               5                   10                  15      


Pro Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro 
            20                  25                  30          


His Ser Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro 
        35                  40                  45              


Ser Gly Xaa Phe Xaa Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser 
    50                  55                  60                  


Gln Ala Cys Met Trp Xaa Leu Arg Ala Pro Xaa Gly Tyr Ile Ile Gln 
65                  70                  75                  80  


Ile Xaa Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr 
                85                  90                  95      


Asp Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Xaa Lys Phe Cys Gly 
            100                 105                 110         


Ala Xaa Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His 
        115                 120                 125             


Val Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly Phe Asn Ala 
    130                 135                 140                 


Ser Tyr Ile Arg Val Ala Val Ser Leu Arg Asn Gln Lys Val Ile Leu 
145                 150                 155                 160 


Pro Gln Xaa Ser Asp Ala Tyr Gln Val Ser Val Ala Lys Ser Ile Ser 
                165                 170                 175     


Ile Pro Glu Leu Ser Ala Phe Xaa Leu Cys Phe Glu Ala Xaa Lys Val 
            180                 185                 190         


Gly His Glu Asp Ser Asp Trp Xaa Ala Phe Ser Tyr Ser Asn Ala Ser 
        195                 200                 205             


Phe Xaa Gln Leu Leu Ser Phe Gly Lys Ala Lys Ser Gly Tyr Phe Leu 
    210                 215                 220                 


Ser Ile Ser Asp Ser Lys Cys Leu Leu Asn Asn Ala Leu Pro Val Lys 
225                 230                 235                 240 


Glu Lys Glu Asp Ile Phe Ala Glu Ser Phe Glu Gln Leu Cys Leu Val 
                245                 250                 255     


Trp Asn Asn Ser Leu Gly Ser Ile Gly Val Asn Phe Lys Arg Asn Tyr 
            260                 265                 270         


Glu Xaa Val Pro Cys Asp Ser Xaa Ile Ser Lys Val Ile Pro Gly Asn 
        275                 280                 285             


Gly Lys Leu Leu Leu Gly Ser Asn Gln Asn Glu Ile Val Ser Leu Lys 
    290                 295                 300                 


Gly Asp Ile Tyr Asn Phe Arg Leu Trp Asn Phe Xaa Met Asn Ala Lys 
305                 310                 315                 320 


Ile Leu Ser Asn Leu Ser Cys Asn Val Lys Gly Asn Val Val Asp Trp 
                325                 330                 335     


Gln Asn Asp Phe Trp Asn Ile Pro Asn Leu Ala Leu Lys Ala Glu Ser 
            340                 345                 350         


Asn Leu Ser Cys Gly Ser Tyr Leu Ile Pro Leu Pro Ala Ala Glu Leu 
        355                 360                 365             


Ala Ser Cys Ala Asp Leu Gly Xaa Leu Cys Gln Asp Gly Ile Ile Tyr 
    370                 375                 380                 


Arg Ile Ser Val Val Ile Gln Asn Ile Leu Arg His Pro Glu Val Lys 
385                 390                 395                 400 


Val Gln Ser Lys Val Ala Glu Trp Leu Asn Ser Xaa Phe Gln Asn Trp 
                405                 410                 415     


Asn Tyr Xaa Val Tyr Val Val Asn Ile Ser Phe His Leu Ser Ala Gly 
            420                 425                 430         


Glu Asp Lys Ile Lys Val Lys Arg Ser Leu Glu Asp Glu Pro Arg Leu 
        435                 440                 445             


Val Leu Trp Ala Leu Leu Val Tyr Asn Ala Xaa Asn Asn Xaa Asn Leu 
    450                 455                 460                 


Glu Gly Lys Ile Ile Gln Gln Lys Leu Leu Lys Asn Asn Glu Ser Leu 
465                 470                 475                 480 


Asp Glu Gly Leu Arg Leu His Xaa Val Asn Val Arg Gln Leu Gly His 
                485                 490                 495     


Cys Leu Ala Met Glu Glu Pro Lys Gly Tyr Tyr Trp Pro Ser Ile Gln 
            500                 505                 510         


Pro Ser Glu Tyr Val Leu Pro Cys Pro Asp Lys Pro Gly Phe Ser Ala 
        515                 520                 525             


Ser Arg Ile Cys Phe Tyr Asn Ala Xaa Asn Pro Leu Val Xaa Tyr Trp 
    530                 535                 540                 


Gly Pro Val Asp Ile Ser Asn Cys Leu Lys Glu Ala Asn Glu Val Ala 
545                 550                 555                 560 


Asn Gln Ile Leu Asn Leu Xaa Ala Asp Gly Gln Asn Leu Xaa Ser Ala 
                565                 570                 575     


Asn Ile Xaa Asn Ile Val Glu Gln Val Lys Arg Ile Val Asn Lys Glu 
            580                 585                 590         


Glu Asn Ile Asp Ile Xaa Leu Gly Ser Xaa Leu Met Asn Ile Phe Ser 
        595                 600                 605             


Asn Ile Leu Ser Ser Ser Asp Ser Asp Leu Leu Glu Ser Ser Ser Glu 
    610                 615                 620                 


Ala Leu Lys Xaa Ile Asp Glu Leu Ala Phe Lys Ile Asp Leu Asn Ser 
625                 630                 635                 640 


Xaa Ser His Val Asn Ile Xaa Xaa Arg Asn Leu Ala Leu Ser Val Ser 
                645                 650                 655     


Ser Leu Leu Pro Gly Xaa Asn Ala Ile Ser Asn Phe Ser Ile Gly Leu 
            660                 665                 670         


Pro Ser Asn Asn Glu Ser Tyr Phe Gln Met Asp Phe Glu Ser Gly Gln 
        675                 680                 685             


Val Asp Pro Leu Ala Ser Val Ile Leu Pro Pro Asn Leu Leu Glu Asn 
    690                 695                 700                 


Leu Ser Pro Glu Asp Ser Val Leu Val Arg Arg Ala Gln Phe Xaa Phe 
705                 710                 715                 720 


Phe Asn Lys Xaa Gly Leu Phe Gln Asp Val Gly Pro Gln Arg Lys Xaa 
                725                 730                 735     


Leu Val Ser Tyr Val Met Ala Cys Ser Ile Gly Asn Ile Xaa Ile Gln 
            740                 745                 750         


Asn Leu Lys Asp Pro Val Gln Ile Lys Ile Lys His Xaa Arg Xaa Gln 
        755                 760                 765             


Glu Val His His Pro Ile Cys Ala Phe Trp Asp Leu Asn Lys Asn Lys 
    770                 775                 780                 


Ser Phe Gly Gly Trp Asn Xaa Ser Gly Cys Val Ala His Arg Asp Ser 
785                 790                 795                 800 


Asp Ala Ser Glu Xaa Val Cys Leu Cys Asn His Phe Xaa His Phe Gly 
                805                 810                 815     


Val Leu Met Asp Leu Pro Arg Ser Ala Ser Gln Leu Asp Ala Arg Asn 
            820                 825                 830         


Xaa Lys Val Leu Xaa Phe Ile Ser Tyr Ile Gly Cys Gly Ile Ser Ala 
        835                 840                 845             


Ile Phe Ser Ala Ala Xaa Leu Leu Xaa Tyr Val Ala Phe Glu Lys Leu 
    850                 855                 860                 


Arg Arg Asp Tyr Pro Ser Lys Ile Leu Met Asn Leu Ser Xaa Ala Leu 
865                 870                 875                 880 


Leu Phe Leu Asn Leu Leu Phe Leu Leu Asp Gly Trp Ile Xaa Ser Phe 
                885                 890                 895     


Asn Val Asp Gly Leu Cys Ile Ala Val Ala Val Leu Leu His Phe Phe 
            900                 905                 910         


Leu Leu Ala Xaa Phe Xaa Trp Met Gly Leu Glu Ala Ile His Met Tyr 
        915                 920                 925             


Ile Ala Leu Val Lys Val Phe Asn Xaa Tyr Ile Arg Arg Tyr Ile Leu 
    930                 935                 940                 


Lys Phe Cys Ile Ile Gly Trp Gly Leu Pro Ala Leu Val Val Ser Val 
945                 950                 955                 960 


Val Leu Ala Ser Arg Asn Asn Asn Glu Val Tyr Gly Lys Glu Ser Tyr 
                965                 970                 975     


Gly Lys Glu Lys Gly Asp Glu Phe Cys Trp Ile Gln Asp Pro Val Ile 
            980                 985                 990         


Phe Tyr Val Xaa Cys Ala Gly Tyr  Phe Gly Val Met Phe  Phe Leu Asn 
        995                 1000                 1005             


Ile Ala  Met Phe Ile Val Val  Met Val Gln Ile Cys  Gly Arg Asn 
    1010                 1015                 1020             


Gly Lys  Arg Ser Asn Arg Xaa  Leu Arg Glu Glu Val  Leu Arg Asn 
    1025                 1030                 1035             


Leu Arg  Ser Val Val Ser Leu  Xaa Phe Leu Leu Gly  Met Xaa Trp 
    1040                 1045                 1050             


Gly Phe  Ala Phe Phe Ala Trp  Gly Pro Leu Asn Ile  Pro Phe Met 
    1055                 1060                 1065             


Tyr Leu  Phe Ser Ile Phe Asn  Ser Leu Gln Gly Leu  Phe Ile Phe 
    1070                 1075                 1080             


Ile Phe  His Cys Ala Met Lys  Glu Asn Val Gln Lys  Gln Trp Arg 
    1085                 1090                 1095             


Gln His  Leu Cys Cys Gly Arg  Phe Arg Leu Ala Asp  Asn Ser Asp 
    1100                 1105                 1110             


Trp Ser  Lys Xaa Ala Xaa Asn  Ile Ile Lys Lys Ser  Ser Asp Asn 
    1115                 1120                 1125             


Leu Gly  Lys Ser Leu Ser Ser  Ser Ser Ile Gly Ser  Asn Ser Xaa 
    1130                 1135                 1140             


Tyr Leu  Xaa Ser Lys Ser Lys  Ser Ser Ser Xaa Xaa  Tyr Phe Lys 
    1145                 1150                 1155             


Arg Asn  Ser His Xaa Asp Asn  Val Ser Tyr Glu His  Ser Phe Asn 
    1160                 1165                 1170             


Lys Ser  Gly Ser Leu Arg Gln  Cys Phe His Gly Gln  Val Leu Val 
    1175                 1180                 1185             


Lys Xaa  Gly Pro Cys 
    1190             


<210> 1749
<211> 1221
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1058)..(1058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1145)..(1145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1191)..(1191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1218)..(1218)
<223> Selenocysteine

<400> 1749
Met Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys 
1               5                   10                  15      


Pro Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro 
            20                  25                  30          


His Ser Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro 
        35                  40                  45              


Ser Gly Xaa Phe Xaa Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser 
    50                  55                  60                  


Gln Ala Cys Met Trp Xaa Leu Arg Ala Pro Xaa Gly Tyr Ile Ile Gln 
65                  70                  75                  80  


Ile Xaa Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr 
                85                  90                  95      


Asp Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Xaa Lys Phe Cys Gly 
            100                 105                 110         


Ala Xaa Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His 
        115                 120                 125             


Val Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly Phe Asn Ala 
    130                 135                 140                 


Ser Tyr Ile Arg Val Ala Val Ser Leu Arg Asn Gln Lys Val Ile Leu 
145                 150                 155                 160 


Pro Gln Xaa Ser Asp Ala Tyr Gln Val Ser Val Ala Lys Ser Ile Ser 
                165                 170                 175     


Ile Pro Glu Leu Ser Ala Phe Xaa Leu Cys Phe Glu Ala Xaa Lys Val 
            180                 185                 190         


Gly His Glu Asp Ser Asp Trp Xaa Ala Phe Ser Tyr Ser Asn Ala Ser 
        195                 200                 205             


Phe Xaa Gln Leu Leu Ser Phe Gly Lys Ala Lys Ser Gly Tyr Phe Leu 
    210                 215                 220                 


Ser Ile Ser Asp Ser Lys Cys Leu Leu Asn Asn Ala Leu Pro Val Lys 
225                 230                 235                 240 


Glu Lys Glu Asp Ile Phe Ala Glu Ser Phe Glu Gln Leu Cys Leu Val 
                245                 250                 255     


Trp Asn Asn Ser Leu Gly Ser Ile Gly Val Asn Phe Lys Arg Asn Tyr 
            260                 265                 270         


Glu Xaa Val Pro Cys Asp Ser Xaa Ile Ser Lys Val Ile Pro Gly Asn 
        275                 280                 285             


Gly Lys Leu Leu Leu Gly Ser Asn Gln Asn Glu Ile Val Ser Leu Lys 
    290                 295                 300                 


Gly Asp Ile Tyr Asn Phe Arg Leu Trp Asn Phe Xaa Met Asn Ala Lys 
305                 310                 315                 320 


Ile Leu Ser Asn Leu Ser Cys Asn Val Lys Gly Asn Val Val Asp Trp 
                325                 330                 335     


Gln Asn Asp Phe Trp Asn Ile Pro Asn Leu Ala Leu Lys Ala Glu Ser 
            340                 345                 350         


Asn Leu Ser Cys Gly Ser Tyr Leu Ile Pro Leu Pro Ala Ala Glu Leu 
        355                 360                 365             


Ala Ser Cys Ala Asp Leu Gly Xaa Leu Cys Gln Ala Xaa Val Asn Ser 
    370                 375                 380                 


Pro Ser Xaa Xaa Pro Pro Xaa Val Xaa Xaa Asn Met Pro Val Xaa Asn 
385                 390                 395                 400 


Arg Ile Asp Lys Gln Arg Asn Asp Gly Ile Ile Tyr Arg Ile Ser Val 
                405                 410                 415     


Val Ile Gln Asn Ile Leu Arg His Pro Glu Val Lys Val Gln Ser Lys 
            420                 425                 430         


Val Ala Glu Trp Leu Asn Ser Xaa Phe Gln Asn Trp Asn Tyr Xaa Val 
        435                 440                 445             


Tyr Val Val Asn Ile Ser Phe His Leu Ser Ala Gly Glu Asp Lys Ile 
    450                 455                 460                 


Lys Val Lys Arg Ser Leu Glu Asp Glu Pro Arg Leu Val Leu Trp Ala 
465                 470                 475                 480 


Leu Leu Val Tyr Asn Ala Xaa Asn Asn Xaa Asn Leu Glu Gly Lys Ile 
                485                 490                 495     


Ile Gln Gln Lys Leu Leu Lys Asn Asn Glu Ser Leu Asp Glu Gly Leu 
            500                 505                 510         


Arg Leu His Xaa Val Asn Val Arg Gln Leu Gly His Cys Leu Ala Met 
        515                 520                 525             


Glu Glu Pro Lys Gly Tyr Tyr Trp Pro Ser Ile Gln Pro Ser Glu Tyr 
    530                 535                 540                 


Val Leu Pro Cys Pro Asp Lys Pro Gly Phe Ser Ala Ser Arg Ile Cys 
545                 550                 555                 560 


Phe Tyr Asn Ala Xaa Asn Pro Leu Val Xaa Tyr Trp Gly Pro Val Asp 
                565                 570                 575     


Ile Ser Asn Cys Leu Lys Glu Ala Asn Glu Val Ala Asn Gln Ile Leu 
            580                 585                 590         


Asn Leu Xaa Ala Asp Gly Gln Asn Leu Xaa Ser Ala Asn Ile Xaa Asn 
        595                 600                 605             


Ile Val Glu Gln Val Lys Arg Ile Val Asn Lys Glu Glu Asn Ile Asp 
    610                 615                 620                 


Ile Xaa Leu Gly Ser Xaa Leu Met Asn Ile Phe Ser Asn Ile Leu Ser 
625                 630                 635                 640 


Ser Ser Asp Ser Asp Leu Leu Glu Ser Ser Ser Glu Ala Leu Lys Xaa 
                645                 650                 655     


Ile Asp Glu Leu Ala Phe Lys Ile Asp Leu Asn Ser Xaa Ser His Val 
            660                 665                 670         


Asn Ile Xaa Xaa Arg Asn Leu Ala Leu Ser Val Ser Ser Leu Leu Pro 
        675                 680                 685             


Gly Xaa Asn Ala Ile Ser Asn Phe Ser Ile Gly Leu Pro Ser Asn Asn 
    690                 695                 700                 


Glu Ser Tyr Phe Gln Met Asp Phe Glu Ser Gly Gln Val Asp Pro Leu 
705                 710                 715                 720 


Ala Ser Val Ile Leu Pro Pro Asn Leu Leu Glu Asn Leu Ser Pro Glu 
                725                 730                 735     


Asp Ser Val Leu Val Arg Arg Ala Gln Phe Xaa Phe Phe Asn Lys Xaa 
            740                 745                 750         


Gly Leu Phe Gln Asp Val Gly Pro Gln Arg Lys Xaa Leu Val Ser Tyr 
        755                 760                 765             


Val Met Ala Cys Ser Ile Gly Asn Ile Xaa Ile Gln Asn Leu Lys Asp 
    770                 775                 780                 


Pro Val Gln Ile Lys Ile Lys His Xaa Arg Xaa Gln Glu Val His His 
785                 790                 795                 800 


Pro Ile Cys Ala Phe Trp Asp Leu Asn Lys Asn Lys Ser Phe Gly Gly 
                805                 810                 815     


Trp Asn Xaa Ser Gly Cys Val Ala His Arg Asp Ser Asp Ala Ser Glu 
            820                 825                 830         


Xaa Val Cys Leu Cys Asn His Phe Xaa His Phe Gly Val Leu Met Asp 
        835                 840                 845             


Leu Pro Arg Ser Ala Ser Gln Leu Asp Ala Arg Asn Xaa Lys Val Leu 
    850                 855                 860                 


Xaa Phe Ile Ser Tyr Ile Gly Cys Gly Ile Ser Ala Ile Phe Ser Ala 
865                 870                 875                 880 


Ala Xaa Leu Leu Xaa Tyr Val Ala Phe Glu Lys Leu Arg Arg Asp Tyr 
                885                 890                 895     


Pro Ser Lys Ile Leu Met Asn Leu Ser Xaa Ala Leu Leu Phe Leu Asn 
            900                 905                 910         


Leu Leu Phe Leu Leu Asp Gly Trp Ile Xaa Ser Phe Asn Val Asp Gly 
        915                 920                 925             


Leu Cys Ile Ala Val Ala Val Leu Leu His Phe Phe Leu Leu Ala Xaa 
    930                 935                 940                 


Phe Xaa Trp Met Gly Leu Glu Ala Ile His Met Tyr Ile Ala Leu Val 
945                 950                 955                 960 


Lys Val Phe Asn Xaa Tyr Ile Arg Arg Tyr Ile Leu Lys Phe Cys Ile 
                965                 970                 975     


Ile Gly Trp Gly Leu Pro Ala Leu Val Val Ser Val Val Leu Ala Ser 
            980                 985                 990         


Arg Asn Asn Asn Glu Val Tyr Gly  Lys Glu Ser Tyr Gly  Lys Glu Lys 
        995                 1000                 1005             


Gly Asp  Glu Phe Cys Trp Ile  Gln Asp Pro Val Ile  Phe Tyr Val 
    1010                 1015                 1020             


Xaa Cys  Ala Gly Tyr Phe Gly  Val Met Phe Phe Leu  Asn Ile Ala 
    1025                 1030                 1035             


Met Phe  Ile Val Val Met Val  Gln Ile Cys Gly Arg  Asn Gly Lys 
    1040                 1045                 1050             


Arg Ser  Asn Arg Xaa Leu Arg  Glu Glu Val Leu Arg  Asn Leu Arg 
    1055                 1060                 1065             


Ser Val  Val Ser Leu Xaa Phe  Leu Leu Gly Met Xaa  Trp Gly Phe 
    1070                 1075                 1080             


Ala Phe  Phe Ala Trp Gly Pro  Leu Asn Ile Pro Phe  Met Tyr Leu 
    1085                 1090                 1095             


Phe Ser  Ile Phe Asn Ser Leu  Gln Gly Leu Phe Ile  Phe Ile Phe 
    1100                 1105                 1110             


His Cys  Ala Met Lys Glu Asn  Val Gln Lys Gln Trp  Arg Gln His 
    1115                 1120                 1125             


Leu Cys  Cys Gly Arg Phe Arg  Leu Ala Asp Asn Ser  Asp Trp Ser 
    1130                 1135                 1140             


Lys Xaa  Ala Xaa Asn Ile Ile  Lys Lys Ser Ser Asp  Asn Leu Gly 
    1145                 1150                 1155             


Lys Ser  Leu Ser Ser Ser Ser  Ile Gly Ser Asn Ser  Xaa Tyr Leu 
    1160                 1165                 1170             


Xaa Ser  Lys Ser Lys Ser Ser  Ser Xaa Xaa Tyr Phe  Lys Arg Asn 
    1175                 1180                 1185             


Ser His  Xaa Asp Asn Val Ser  Tyr Glu His Ser Phe  Asn Lys Ser 
    1190                 1195                 1200             


Gly Ser  Leu Arg Gln Cys Phe  His Gly Gln Val Leu  Val Lys Xaa 
    1205                 1210                 1215             


Gly Pro  Cys 
    1220     


<210> 1750
<211> 1222
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (996)..(996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1117)..(1117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<400> 1750
Met Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys 
1               5                   10                  15      


Pro Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro 
            20                  25                  30          


His Ser Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro 
        35                  40                  45              


Ser Gly Xaa Phe Xaa Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser 
    50                  55                  60                  


Gln Ala Cys Met Trp Xaa Leu Arg Ala Pro Xaa Gly Tyr Ile Ile Gln 
65                  70                  75                  80  


Ile Xaa Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr 
                85                  90                  95      


Asp Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Xaa Lys Phe Cys Gly 
            100                 105                 110         


Ala Xaa Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His 
        115                 120                 125             


Val Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly Phe Asn Ala 
    130                 135                 140                 


Ser Tyr Ile Arg Val Ala Val Ser Leu Arg Asn Gln Lys Val Ile Leu 
145                 150                 155                 160 


Pro Gln Xaa Ser Asp Ala Tyr Gln Val Ser Val Ala Lys Ser Ile Ser 
                165                 170                 175     


Ile Pro Glu Leu Ser Ala Phe Xaa Leu Cys Phe Glu Ala Xaa Lys Val 
            180                 185                 190         


Gly His Glu Asp Ser Asp Trp Xaa Ala Phe Ser Tyr Ser Asn Ala Ser 
        195                 200                 205             


Phe Xaa Gln Leu Leu Ser Phe Gly Lys Ala Lys Ser Gly Tyr Phe Leu 
    210                 215                 220                 


Ser Ile Ser Asp Ser Lys Cys Leu Leu Asn Asn Ala Leu Pro Val Lys 
225                 230                 235                 240 


Glu Lys Glu Asp Ile Phe Ala Glu Ser Phe Glu Gln Leu Cys Leu Val 
                245                 250                 255     


Trp Asn Asn Ser Leu Gly Ser Ile Gly Val Asn Phe Lys Arg Asn Tyr 
            260                 265                 270         


Glu Xaa Val Pro Cys Asp Ser Xaa Ile Ser Lys Val Ile Pro Gly Asn 
        275                 280                 285             


Gly Lys Leu Leu Leu Gly Ser Asn Gln Asn Glu Ile Val Ser Leu Lys 
    290                 295                 300                 


Gly Asp Ile Tyr Asn Phe Arg Leu Trp Asn Phe Xaa Met Asn Ala Lys 
305                 310                 315                 320 


Ile Leu Ser Asn Leu Ser Cys Asn Val Lys Gly Asn Val Val Asp Trp 
                325                 330                 335     


Gln Asn Asp Phe Trp Asn Ile Pro Asn Leu Ala Leu Lys Ala Glu Ser 
            340                 345                 350         


Asn Leu Ser Cys Gly Ser Tyr Leu Ile Pro Leu Pro Ala Ala Glu Leu 
        355                 360                 365             


Ala Ser Cys Ala Asp Leu Gly Xaa Leu Cys Gln Asp Gly Ile Ile Tyr 
    370                 375                 380                 


Arg Ile Ser Val Val Ile Gln Asn Ile Leu Arg His Pro Glu Val Lys 
385                 390                 395                 400 


Val Gln Ser Lys Val Ala Glu Trp Leu Asn Ser Xaa Phe Gln Asn Trp 
                405                 410                 415     


Asn Tyr Xaa Val Tyr Val Val Asn Ile Ser Phe His Leu Ser Ala Gly 
            420                 425                 430         


Glu Asp Lys Ile Lys Val Lys Arg Ser Leu Glu Asp Glu Pro Arg Leu 
        435                 440                 445             


Val Leu Trp Ala Leu Leu Val Tyr Asn Ala Xaa Asn Asn Xaa Asn Leu 
    450                 455                 460                 


Glu Gly Lys Ile Ile Gln Gln Lys Leu Leu Lys Asn Asn Glu Ser Leu 
465                 470                 475                 480 


Asp Glu Gly Leu Arg Leu His Xaa Val Asn Val Arg Gln Leu Gly His 
                485                 490                 495     


Cys Leu Ala Met Glu Glu Pro Lys Gly Tyr Tyr Trp Pro Ser Ile Gln 
            500                 505                 510         


Pro Ser Glu Tyr Val Leu Pro Cys Pro Asp Lys Pro Gly Phe Ser Ala 
        515                 520                 525             


Ser Arg Ile Cys Phe Tyr Asn Ala Xaa Asn Pro Leu Val Xaa Tyr Trp 
    530                 535                 540                 


Gly Pro Val Asp Ile Ser Asn Cys Leu Lys Glu Ala Asn Glu Val Ala 
545                 550                 555                 560 


Asn Gln Ile Leu Asn Leu Xaa Ala Asp Gly Gln Asn Leu Xaa Ser Ala 
                565                 570                 575     


Asn Ile Xaa Asn Ile Val Glu Gln Val Lys Arg Ile Val Asn Lys Glu 
            580                 585                 590         


Glu Asn Ile Asp Ile Xaa Leu Gly Ser Xaa Leu Met Asn Ile Phe Ser 
        595                 600                 605             


Asn Ile Leu Ser Ser Ser Asp Ser Asp Leu Leu Glu Ser Ser Ser Glu 
    610                 615                 620                 


Ala Leu Lys Xaa Ile Asp Glu Leu Ala Phe Lys Ile Asp Leu Asn Ser 
625                 630                 635                 640 


Xaa Ser His Val Asn Ile Xaa Xaa Arg Asn Leu Ala Leu Ser Val Ser 
                645                 650                 655     


Ser Leu Leu Pro Gly Xaa Asn Ala Ile Ser Asn Phe Ser Ile Gly Leu 
            660                 665                 670         


Pro Ser Asn Asn Glu Ser Tyr Phe Gln Met Asp Phe Glu Ser Gly Gln 
        675                 680                 685             


Val Asp Pro Leu Ala Ser Val Ile Leu Pro Pro Asn Leu Leu Glu Asn 
    690                 695                 700                 


Leu Ser Pro Glu Asp Ser Val Leu Val Arg Arg Ala Gln Phe Xaa Phe 
705                 710                 715                 720 


Phe Asn Lys Xaa Gly Leu Phe Gln Asp Val Gly Pro Gln Arg Lys Xaa 
                725                 730                 735     


Leu Val Ser Tyr Val Met Ala Cys Ser Ile Gly Asn Ile Xaa Ile Gln 
            740                 745                 750         


Asn Leu Lys Asp Pro Val Gln Ile Lys Ile Lys His Xaa Arg Xaa Gln 
        755                 760                 765             


Glu Val His His Pro Ile Cys Ala Phe Trp Asp Leu Asn Lys Asn Lys 
    770                 775                 780                 


Ser Phe Gly Gly Trp Asn Xaa Ser Gly Cys Val Ala His Arg Asp Ser 
785                 790                 795                 800 


Asp Ala Ser Glu Xaa Val Cys Leu Cys Asn His Phe Xaa His Phe Gly 
                805                 810                 815     


Val Leu Met Asp Leu Pro Arg Ser Ala Ser Gln Leu Asp Ala Arg Asn 
            820                 825                 830         


Xaa Lys Val Leu Xaa Phe Ile Ser Tyr Ile Gly Cys Gly Ile Ser Ala 
        835                 840                 845             


Ile Phe Ser Ala Ala Xaa Leu Leu Xaa Tyr Val Ala Phe Glu Lys Leu 
    850                 855                 860                 


Arg Arg Asp Tyr Pro Ser Lys Ile Leu Met Asn Leu Ser Xaa Ala Leu 
865                 870                 875                 880 


Leu Phe Leu Asn Leu Leu Phe Leu Leu Asp Gly Trp Ile Xaa Ser Phe 
                885                 890                 895     


Asn Val Asp Gly Leu Cys Ile Ala Val Ala Val Leu Leu His Phe Phe 
            900                 905                 910         


Leu Leu Ala Xaa Phe Xaa Trp Met Gly Leu Glu Ala Ile His Met Tyr 
        915                 920                 925             


Ile Ala Leu Val Lys Val Phe Asn Xaa Tyr Ile Arg Arg Tyr Ile Leu 
    930                 935                 940                 


Lys Phe Cys Ile Ile Gly Trp Gly Leu Pro Ala Leu Val Val Ser Val 
945                 950                 955                 960 


Val Leu Ala Ser Arg Asn Asn Asn Glu Val Tyr Gly Lys Glu Ser Tyr 
                965                 970                 975     


Gly Lys Glu Lys Gly Asp Glu Phe Cys Trp Ile Gln Asp Pro Val Ile 
            980                 985                 990         


Phe Tyr Val Xaa Cys Ala Gly Tyr  Phe Gly Val Met Phe  Phe Leu Asn 
        995                 1000                 1005             


Ile Ala  Met Phe Ile Val Val  Met Val Gln Ile Cys  Gly Arg Asn 
    1010                 1015                 1020             


Gly Lys  Arg Ser Asn Arg Xaa  Leu Arg Glu Glu Val  Leu Arg Asn 
    1025                 1030                 1035             


Leu Arg  Ser Val Val Ser Leu  Xaa Phe Leu Leu Gly  Met Xaa Trp 
    1040                 1045                 1050             


Gly Phe  Ala Phe Phe Ala Trp  Gly Pro Leu Asn Ile  Pro Phe Met 
    1055                 1060                 1065             


Tyr Leu  Phe Ser Ile Phe Asn  Ser Leu Gln Gly Leu  Phe Ile Phe 
    1070                 1075                 1080             


Ile Phe  His Cys Ala Met Lys  Glu Asn Val Gln Lys  Gln Trp Arg 
    1085                 1090                 1095             


Gln His  Leu Cys Cys Gly Arg  Phe Arg Leu Ala Asp  Asn Ser Asp 
    1100                 1105                 1110             


Trp Ser  Lys Xaa Ala Xaa Asn  Ile Ile Lys Lys Ser  Ser Asp Asn 
    1115                 1120                 1125             


Leu Gly  Lys Ser Leu Ser Ser  Ser Ser Ile Gly Ser  Asn Ser Xaa 
    1130                 1135                 1140             


Tyr Leu  Xaa Ser Lys Ser Lys  Ser Ser Ser Xaa Xaa  Tyr Phe Lys 
    1145                 1150                 1155             


Arg Asn  Ser His Xaa Asp Ser  Ala Ser Met Asp Lys  Ser Leu Ser 
    1160                 1165                 1170             


Lys Leu  Ala His Ala Asp Gly  Asp Gln Xaa Ser Ile  Ile Pro Val 
    1175                 1180                 1185             


His Gln  Val Ile Asp Lys Val  Lys Gly Tyr Cys Asn  Ala His Ser 
    1190                 1195                 1200             


Asp Asn  Phe Tyr Lys Asn Ile  Ile Met Ser Asp Xaa  Phe Ser His 
    1205                 1210                 1215             


Ser Xaa  Lys Phe 
    1220         


<210> 1751
<211> 1250
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1058)..(1058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1145)..(1145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1191)..(1191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1211)..(1211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1243)..(1243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1248)..(1248)
<223> Selenocysteine

<400> 1751
Met Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys 
1               5                   10                  15      


Pro Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro 
            20                  25                  30          


His Ser Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro 
        35                  40                  45              


Ser Gly Xaa Phe Xaa Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser 
    50                  55                  60                  


Gln Ala Cys Met Trp Xaa Leu Arg Ala Pro Xaa Gly Tyr Ile Ile Gln 
65                  70                  75                  80  


Ile Xaa Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr 
                85                  90                  95      


Asp Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Xaa Lys Phe Cys Gly 
            100                 105                 110         


Ala Xaa Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His 
        115                 120                 125             


Val Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly Phe Asn Ala 
    130                 135                 140                 


Ser Tyr Ile Arg Val Ala Val Ser Leu Arg Asn Gln Lys Val Ile Leu 
145                 150                 155                 160 


Pro Gln Xaa Ser Asp Ala Tyr Gln Val Ser Val Ala Lys Ser Ile Ser 
                165                 170                 175     


Ile Pro Glu Leu Ser Ala Phe Xaa Leu Cys Phe Glu Ala Xaa Lys Val 
            180                 185                 190         


Gly His Glu Asp Ser Asp Trp Xaa Ala Phe Ser Tyr Ser Asn Ala Ser 
        195                 200                 205             


Phe Xaa Gln Leu Leu Ser Phe Gly Lys Ala Lys Ser Gly Tyr Phe Leu 
    210                 215                 220                 


Ser Ile Ser Asp Ser Lys Cys Leu Leu Asn Asn Ala Leu Pro Val Lys 
225                 230                 235                 240 


Glu Lys Glu Asp Ile Phe Ala Glu Ser Phe Glu Gln Leu Cys Leu Val 
                245                 250                 255     


Trp Asn Asn Ser Leu Gly Ser Ile Gly Val Asn Phe Lys Arg Asn Tyr 
            260                 265                 270         


Glu Xaa Val Pro Cys Asp Ser Xaa Ile Ser Lys Val Ile Pro Gly Asn 
        275                 280                 285             


Gly Lys Leu Leu Leu Gly Ser Asn Gln Asn Glu Ile Val Ser Leu Lys 
    290                 295                 300                 


Gly Asp Ile Tyr Asn Phe Arg Leu Trp Asn Phe Xaa Met Asn Ala Lys 
305                 310                 315                 320 


Ile Leu Ser Asn Leu Ser Cys Asn Val Lys Gly Asn Val Val Asp Trp 
                325                 330                 335     


Gln Asn Asp Phe Trp Asn Ile Pro Asn Leu Ala Leu Lys Ala Glu Ser 
            340                 345                 350         


Asn Leu Ser Cys Gly Ser Tyr Leu Ile Pro Leu Pro Ala Ala Glu Leu 
        355                 360                 365             


Ala Ser Cys Ala Asp Leu Gly Xaa Leu Cys Gln Ala Xaa Val Asn Ser 
    370                 375                 380                 


Pro Ser Xaa Xaa Pro Pro Xaa Val Xaa Xaa Asn Met Pro Val Xaa Asn 
385                 390                 395                 400 


Arg Ile Asp Lys Gln Arg Asn Asp Gly Ile Ile Tyr Arg Ile Ser Val 
                405                 410                 415     


Val Ile Gln Asn Ile Leu Arg His Pro Glu Val Lys Val Gln Ser Lys 
            420                 425                 430         


Val Ala Glu Trp Leu Asn Ser Xaa Phe Gln Asn Trp Asn Tyr Xaa Val 
        435                 440                 445             


Tyr Val Val Asn Ile Ser Phe His Leu Ser Ala Gly Glu Asp Lys Ile 
    450                 455                 460                 


Lys Val Lys Arg Ser Leu Glu Asp Glu Pro Arg Leu Val Leu Trp Ala 
465                 470                 475                 480 


Leu Leu Val Tyr Asn Ala Xaa Asn Asn Xaa Asn Leu Glu Gly Lys Ile 
                485                 490                 495     


Ile Gln Gln Lys Leu Leu Lys Asn Asn Glu Ser Leu Asp Glu Gly Leu 
            500                 505                 510         


Arg Leu His Xaa Val Asn Val Arg Gln Leu Gly His Cys Leu Ala Met 
        515                 520                 525             


Glu Glu Pro Lys Gly Tyr Tyr Trp Pro Ser Ile Gln Pro Ser Glu Tyr 
    530                 535                 540                 


Val Leu Pro Cys Pro Asp Lys Pro Gly Phe Ser Ala Ser Arg Ile Cys 
545                 550                 555                 560 


Phe Tyr Asn Ala Xaa Asn Pro Leu Val Xaa Tyr Trp Gly Pro Val Asp 
                565                 570                 575     


Ile Ser Asn Cys Leu Lys Glu Ala Asn Glu Val Ala Asn Gln Ile Leu 
            580                 585                 590         


Asn Leu Xaa Ala Asp Gly Gln Asn Leu Xaa Ser Ala Asn Ile Xaa Asn 
        595                 600                 605             


Ile Val Glu Gln Val Lys Arg Ile Val Asn Lys Glu Glu Asn Ile Asp 
    610                 615                 620                 


Ile Xaa Leu Gly Ser Xaa Leu Met Asn Ile Phe Ser Asn Ile Leu Ser 
625                 630                 635                 640 


Ser Ser Asp Ser Asp Leu Leu Glu Ser Ser Ser Glu Ala Leu Lys Xaa 
                645                 650                 655     


Ile Asp Glu Leu Ala Phe Lys Ile Asp Leu Asn Ser Xaa Ser His Val 
            660                 665                 670         


Asn Ile Xaa Xaa Arg Asn Leu Ala Leu Ser Val Ser Ser Leu Leu Pro 
        675                 680                 685             


Gly Xaa Asn Ala Ile Ser Asn Phe Ser Ile Gly Leu Pro Ser Asn Asn 
    690                 695                 700                 


Glu Ser Tyr Phe Gln Met Asp Phe Glu Ser Gly Gln Val Asp Pro Leu 
705                 710                 715                 720 


Ala Ser Val Ile Leu Pro Pro Asn Leu Leu Glu Asn Leu Ser Pro Glu 
                725                 730                 735     


Asp Ser Val Leu Val Arg Arg Ala Gln Phe Xaa Phe Phe Asn Lys Xaa 
            740                 745                 750         


Gly Leu Phe Gln Asp Val Gly Pro Gln Arg Lys Xaa Leu Val Ser Tyr 
        755                 760                 765             


Val Met Ala Cys Ser Ile Gly Asn Ile Xaa Ile Gln Asn Leu Lys Asp 
    770                 775                 780                 


Pro Val Gln Ile Lys Ile Lys His Xaa Arg Xaa Gln Glu Val His His 
785                 790                 795                 800 


Pro Ile Cys Ala Phe Trp Asp Leu Asn Lys Asn Lys Ser Phe Gly Gly 
                805                 810                 815     


Trp Asn Xaa Ser Gly Cys Val Ala His Arg Asp Ser Asp Ala Ser Glu 
            820                 825                 830         


Xaa Val Cys Leu Cys Asn His Phe Xaa His Phe Gly Val Leu Met Asp 
        835                 840                 845             


Leu Pro Arg Ser Ala Ser Gln Leu Asp Ala Arg Asn Xaa Lys Val Leu 
    850                 855                 860                 


Xaa Phe Ile Ser Tyr Ile Gly Cys Gly Ile Ser Ala Ile Phe Ser Ala 
865                 870                 875                 880 


Ala Xaa Leu Leu Xaa Tyr Val Ala Phe Glu Lys Leu Arg Arg Asp Tyr 
                885                 890                 895     


Pro Ser Lys Ile Leu Met Asn Leu Ser Xaa Ala Leu Leu Phe Leu Asn 
            900                 905                 910         


Leu Leu Phe Leu Leu Asp Gly Trp Ile Xaa Ser Phe Asn Val Asp Gly 
        915                 920                 925             


Leu Cys Ile Ala Val Ala Val Leu Leu His Phe Phe Leu Leu Ala Xaa 
    930                 935                 940                 


Phe Xaa Trp Met Gly Leu Glu Ala Ile His Met Tyr Ile Ala Leu Val 
945                 950                 955                 960 


Lys Val Phe Asn Xaa Tyr Ile Arg Arg Tyr Ile Leu Lys Phe Cys Ile 
                965                 970                 975     


Ile Gly Trp Gly Leu Pro Ala Leu Val Val Ser Val Val Leu Ala Ser 
            980                 985                 990         


Arg Asn Asn Asn Glu Val Tyr Gly  Lys Glu Ser Tyr Gly  Lys Glu Lys 
        995                 1000                 1005             


Gly Asp  Glu Phe Cys Trp Ile  Gln Asp Pro Val Ile  Phe Tyr Val 
    1010                 1015                 1020             


Xaa Cys  Ala Gly Tyr Phe Gly  Val Met Phe Phe Leu  Asn Ile Ala 
    1025                 1030                 1035             


Met Phe  Ile Val Val Met Val  Gln Ile Cys Gly Arg  Asn Gly Lys 
    1040                 1045                 1050             


Arg Ser  Asn Arg Xaa Leu Arg  Glu Glu Val Leu Arg  Asn Leu Arg 
    1055                 1060                 1065             


Ser Val  Val Ser Leu Xaa Phe  Leu Leu Gly Met Xaa  Trp Gly Phe 
    1070                 1075                 1080             


Ala Phe  Phe Ala Trp Gly Pro  Leu Asn Ile Pro Phe  Met Tyr Leu 
    1085                 1090                 1095             


Phe Ser  Ile Phe Asn Ser Leu  Gln Gly Leu Phe Ile  Phe Ile Phe 
    1100                 1105                 1110             


His Cys  Ala Met Lys Glu Asn  Val Gln Lys Gln Trp  Arg Gln His 
    1115                 1120                 1125             


Leu Cys  Cys Gly Arg Phe Arg  Leu Ala Asp Asn Ser  Asp Trp Ser 
    1130                 1135                 1140             


Lys Xaa  Ala Xaa Asn Ile Ile  Lys Lys Ser Ser Asp  Asn Leu Gly 
    1145                 1150                 1155             


Lys Ser  Leu Ser Ser Ser Ser  Ile Gly Ser Asn Ser  Xaa Tyr Leu 
    1160                 1165                 1170             


Xaa Ser  Lys Ser Lys Ser Ser  Ser Xaa Xaa Tyr Phe  Lys Arg Asn 
    1175                 1180                 1185             


Ser His  Xaa Asp Ser Ala Ser  Met Asp Lys Ser Leu  Ser Lys Leu 
    1190                 1195                 1200             


Ala His  Ala Asp Gly Asp Gln  Xaa Ser Ile Ile Pro  Val His Gln 
    1205                 1210                 1215             


Val Ile  Asp Lys Val Lys Gly  Tyr Cys Asn Ala His  Ser Asp Asn 
    1220                 1225                 1230             


Phe Tyr  Lys Asn Ile Ile Met  Ser Asp Xaa Phe Ser  His Ser Xaa 
    1235                 1240                 1245             


Lys Phe  
    1250 


<210> 1752
<211> 103
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 1752
Xaa Leu Gly Ser Xaa Leu Met Asn Ile Phe Ser Asn Ile Leu Ser Ser 
1               5                   10                  15      


Ser Asp Ser Asp Leu Leu Glu Ser Ser Ser Glu Ala Leu Lys Xaa Ile 
            20                  25                  30          


Asp Glu Leu Ala Phe Lys Ile Asp Leu Asn Ser Xaa Ser His Val Asn 
        35                  40                  45              


Ile Xaa Xaa Arg Asn Leu Ala Leu Ser Val Ser Ser Leu Leu Pro Gly 
    50                  55                  60                  


Xaa Asn Ala Ile Ser Asn Phe Ser Ile Gly Leu Pro Ser Asn Asn Glu 
65                  70                  75                  80  


Ser Tyr Phe Gln Leu Leu Ser Phe Xaa Xaa Cys Phe Glu Lys Xaa Ser 
                85                  90                  95      


Lys Ser Ala Ala Asp Gly Phe 
            100             


<210> 1753
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<400> 1753
Xaa Val Lys Val Gln Ser Lys Val Ala Glu Trp Leu Asn Ser Xaa Phe 
1               5                   10                  15      


Gln Asn Trp Asn Tyr Xaa Val Tyr Val Val Asn Ile Ser Phe His Leu 
            20                  25                  30          


Ser Ala Gly Glu Asp Lys Ile Lys Val Lys Arg Ser Leu Glu Asp Glu 
        35                  40                  45              


Pro Arg Leu Val Leu Trp Ala Leu Leu Val Tyr Asn Ala Xaa Asn Asn 
    50                  55                  60                  


Xaa Asn Leu Glu Gly Lys Ile Ile Gln Gln Lys Leu Leu Lys Asn Asn 
65                  70                  75                  80  


Glu Ser Leu Asp Glu Gly Leu Arg Leu His Xaa Val Asn Val Arg Gln 
                85                  90                  95      


Leu Gly His Cys Leu Ala Met Glu Glu Pro Lys Gly Tyr Tyr Trp Pro 
            100                 105                 110         


Ser Ile Gln Pro Ser Glu Tyr Val Leu Pro Cys Pro Asp Lys Pro Gly 
        115                 120                 125             


Phe Ser Ala Ser Arg Ile Trp 
    130                 135 


<210> 1754
<211> 797
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<400> 1754
Met Ala Ser Cys Arg Ala Trp Asn Leu Arg Val Leu Val Ala Val Val 
1               5                   10                  15      


Cys Gly Leu Leu Xaa Gly Ile Ile Leu Gly Leu Gly Ile Trp Arg Ile 
            20                  25                  30          


Val Ile Arg Ile Gln Arg Gly Lys Ser Xaa Ser Ser Ser Ser Xaa Pro 
        35                  40                  45              


Xaa Glu Phe Cys Arg Asn Gly Gly Xaa Trp Glu Asn Gly Arg Cys Ile 
    50                  55                  60                  


Cys Xaa Glu Glu Trp Lys Gly Leu Arg Cys Xaa Ile Ala Asn Phe Cys 
65                  70                  75                  80  


Glu Asn Ser Xaa Tyr Met Gly Phe Xaa Phe Ala Arg Ile Pro Val Gly 
                85                  90                  95      


Arg Tyr Gly Pro Ser Leu Gln Xaa Cys Gly Lys Asp Xaa Pro Asn Ala 
            100                 105                 110         


Gly Asn Pro Met Ala Val Arg Leu Cys Ser Leu Ser Leu Tyr Gly Glu 
        115                 120                 125             


Ile Glu Leu Gln Lys Val Xaa Ile Gly Asn Cys Asn Glu Asn Leu Glu 
    130                 135                 140                 


Xaa Leu Glu Lys Gln Val Lys Asp Val Xaa Ala Pro Leu Asn Asn Ile 
145                 150                 155                 160 


Ser Ser Glu Val Gln Ile Leu Xaa Ser Asp Ala Asn Lys Leu Xaa Ala 
                165                 170                 175     


Glu Asn Ile Xaa Ser Ala Xaa Arg Val Val Gly Gln Ile Phe Asn Xaa 
            180                 185                 190         


Ser Arg Asn Ala Ser Pro Glu Ala Lys Lys Val Ala Ile Val Xaa Val 
        195                 200                 205             


Ser Gln Leu Leu Asp Ala Ser Glu Asp Ala Phe Gln Arg Val Ala Ala 
    210                 215                 220                 


Xaa Ala Asn Asp Asp Ala Leu Xaa Xaa Leu Ile Glu Gln Met Glu Xaa 
225                 230                 235                 240 


Tyr Ser Leu Ser Leu Gly Asn Gln Ser Val Val Glu Pro Asn Ile Ala 
                245                 250                 255     


Ile Gln Ser Ala Asn Phe Ser Ser Glu Asn Ala Val Gly Pro Ser Asn 
            260                 265                 270         


Val Arg Phe Ser Val Gln Lys Gly Ala Ser Ser Ser Leu Val Ser Ser 
        275                 280                 285             


Ser Xaa Phe Ile His Xaa Asn Val Asp Gly Leu Asn Pro Asp Ala Gln 
    290                 295                 300                 


Xaa Glu Leu Gln Val Leu Leu Asn Met Xaa Lys Asn Tyr Xaa Lys Xaa 
305                 310                 315                 320 


Cys Gly Phe Val Val Tyr Gln Asn Asp Lys Leu Phe Gln Ser Lys Xaa 
                325                 330                 335     


Phe Xaa Ala Lys Ser Asp Phe Ser Gln Lys Ile Ile Ser Ser Lys Xaa 
            340                 345                 350         


Asp Glu Asn Glu Gln Asp Gln Ser Ala Ser Val Asp Met Val Phe Ser 
        355                 360                 365             


Pro Lys Tyr Asn Gln Lys Glu Phe Gln Leu Tyr Ser Tyr Ala Cys Val 
    370                 375                 380                 


Tyr Trp Asn Leu Ser Ala Lys Asp Trp Asp Xaa Tyr Gly Cys Gln Lys 
385                 390                 395                 400 


Asp Lys Gly Xaa Asp Gly Phe Leu Arg Cys Arg Cys Asn His Xaa Xaa 
                405                 410                 415     


Asn Phe Ala Val Leu Met Xaa Phe Lys Lys Asp Tyr Gln Tyr Pro Lys 
            420                 425                 430         


Ser Leu Asp Ile Leu Ser Asn Val Gly Cys Ala Leu Ser Val Xaa Gly 
        435                 440                 445             


Leu Ala Leu Xaa Val Ile Phe Gln Ile Val Xaa Arg Lys Val Arg Lys 
    450                 455                 460                 


Xaa Ser Val Xaa Trp Val Leu Val Asn Leu Cys Ile Ser Met Leu Ile 
465                 470                 475                 480 


Phe Asn Leu Leu Phe Val Phe Gly Ile Glu Asn Ser Asn Lys Asn Leu 
                485                 490                 495     


Gln Xaa Ser Asp Gly Asp Ile Asn Asn Ile Asp Phe Asp Asn Asn Asp 
            500                 505                 510         


Ile Pro Arg Xaa Asp Xaa Ile Asn Ile Pro Asn Pro Met Cys Xaa Ala 
        515                 520                 525             


Ile Ala Ala Leu Leu His Tyr Phe Leu Leu Val Xaa Phe Xaa Trp Asn 
    530                 535                 540                 


Ala Leu Ser Ala Ala Gln Leu Tyr Tyr Leu Leu Ile Arg Xaa Met Lys 
545                 550                 555                 560 


Pro Leu Pro Arg His Phe Ile Leu Phe Ile Ser Leu Ile Gly Trp Gly 
                565                 570                 575     


Val Pro Ala Ile Val Val Ala Ile Xaa Val Gly Val Ile Tyr Ser Gln 
            580                 585                 590         


Asn Gly Asn Asn Pro Gln Trp Glu Leu Asp Tyr Arg Gln Glu Lys Ile 
        595                 600                 605             


Cys Trp Leu Ala Ile Pro Glu Pro Asn Gly Val Ile Lys Ser Pro Leu 
    610                 615                 620                 


Leu Trp Ser Phe Ile Val Pro Val Xaa Ile Ile Leu Ile Ser Asn Val 
625                 630                 635                 640 


Val Met Phe Ile Xaa Ile Ser Ile Lys Val Leu Trp Lys Asn Asn Gln 
                645                 650                 655     


Asn Leu Xaa Ser Xaa Lys Lys Val Ser Ser Met Lys Lys Ile Val Ser 
            660                 665                 670         


Xaa Leu Ser Val Ala Val Val Phe Gly Ile Xaa Trp Ile Leu Ala Tyr 
        675                 680                 685             


Leu Met Leu Val Asn Asp Asp Ser Ile Arg Ile Val Phe Ser Tyr Ile 
    690                 695                 700                 


Phe Cys Leu Phe Asn Xaa Xaa Gln Gly Leu Gln Ile Phe Ile Leu Tyr 
705                 710                 715                 720 


Xaa Val Arg Xaa Lys Val Phe Gln Ser Glu Ala Ser Lys Val Leu Met 
                725                 730                 735     


Leu Leu Ser Ser Ile Gly Arg Arg Lys Ser Leu Pro Ser Val Xaa Arg 
            740                 745                 750         


Pro Arg Leu Arg Val Lys Met Tyr Asn Phe Leu Arg Ser Leu Pro Xaa 
        755                 760                 765             


Leu His Glu Arg Phe Arg Leu Leu Glu Xaa Ser Pro Ser Xaa Glu Glu 
    770                 775                 780                 


Ile Xaa Leu Ser Glu Ser Asp Asn Ala Lys Glu Ser Ile 
785                 790                 795         


<210> 1755
<211> 502
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<400> 1755
Met Pro Val Lys Met Leu Phe Lys Glu Leu Leu Leu Leu Leu Met Met 
1               5                   10                  15      


Met Pro Leu Gln His Tyr Xaa Lys Xaa Cys Gly Phe Val Val Tyr Gln 
            20                  25                  30          


Asn Asp Lys Leu Phe Gln Ser Lys Xaa Phe Xaa Ala Lys Ser Asp Phe 
        35                  40                  45              


Ser Gln Lys Ile Ile Ser Ser Lys Xaa Asp Glu Asn Glu Gln Asp Gln 
    50                  55                  60                  


Ser Ala Ser Val Asp Met Val Phe Ser Pro Lys Tyr Asn Gln Lys Glu 
65                  70                  75                  80  


Phe Gln Leu Tyr Ser Tyr Ala Cys Val Tyr Trp Asn Leu Ser Ala Lys 
                85                  90                  95      


Asp Trp Asp Xaa Tyr Gly Cys Gln Lys Asp Lys Gly Xaa Asp Gly Phe 
            100                 105                 110         


Leu Arg Cys Arg Cys Asn His Xaa Xaa Asn Phe Ala Val Leu Met Xaa 
        115                 120                 125             


Phe Lys Lys Asp Tyr Gln Tyr Pro Lys Ser Leu Asp Ile Leu Ser Asn 
    130                 135                 140                 


Val Gly Cys Ala Leu Ser Val Xaa Gly Leu Ala Leu Xaa Val Ile Phe 
145                 150                 155                 160 


Gln Ile Val Xaa Arg Lys Val Arg Lys Xaa Ser Val Xaa Trp Val Leu 
                165                 170                 175     


Val Asn Leu Cys Ile Ser Met Leu Ile Phe Asn Leu Leu Phe Val Phe 
            180                 185                 190         


Gly Ile Glu Asn Ser Asn Lys Asn Leu Gln Xaa Ser Asp Gly Asp Ile 
        195                 200                 205             


Asn Asn Ile Asp Phe Asp Asn Asn Asp Ile Pro Arg Xaa Asp Xaa Ile 
    210                 215                 220                 


Asn Ile Pro Asn Pro Met Cys Xaa Ala Ile Ala Ala Leu Leu His Tyr 
225                 230                 235                 240 


Phe Leu Leu Val Xaa Phe Xaa Trp Asn Ala Leu Ser Ala Ala Gln Leu 
                245                 250                 255     


Tyr Tyr Leu Leu Ile Arg Xaa Met Lys Pro Leu Pro Arg His Phe Ile 
            260                 265                 270         


Leu Phe Ile Ser Leu Ile Gly Trp Gly Val Pro Ala Ile Val Val Ala 
        275                 280                 285             


Ile Xaa Val Gly Val Ile Tyr Ser Gln Asn Gly Asn Asn Pro Gln Trp 
    290                 295                 300                 


Glu Leu Asp Tyr Arg Gln Glu Lys Ile Cys Trp Leu Ala Ile Pro Glu 
305                 310                 315                 320 


Pro Asn Gly Val Ile Lys Ser Pro Leu Leu Trp Ser Phe Ile Val Pro 
                325                 330                 335     


Val Xaa Ile Ile Leu Ile Ser Asn Val Val Met Phe Ile Xaa Ile Ser 
            340                 345                 350         


Ile Lys Val Leu Trp Lys Asn Asn Gln Asn Leu Xaa Ser Xaa Lys Lys 
        355                 360                 365             


Val Ser Ser Met Lys Lys Ile Val Ser Xaa Leu Ser Val Ala Val Val 
    370                 375                 380                 


Phe Gly Ile Xaa Trp Ile Leu Ala Tyr Leu Met Leu Val Asn Asp Asp 
385                 390                 395                 400 


Ser Ile Arg Ile Val Phe Ser Tyr Ile Phe Cys Leu Phe Asn Xaa Xaa 
                405                 410                 415     


Gln Gly Leu Gln Ile Phe Ile Leu Tyr Xaa Val Arg Xaa Lys Val Phe 
            420                 425                 430         


Gln Ser Glu Ala Ser Lys Val Leu Met Leu Leu Ser Ser Ile Gly Arg 
        435                 440                 445             


Arg Lys Ser Leu Pro Ser Val Xaa Arg Pro Arg Leu Arg Val Lys Met 
    450                 455                 460                 


Tyr Asn Phe Leu Arg Ser Leu Pro Xaa Leu His Glu Arg Phe Arg Leu 
465                 470                 475                 480 


Leu Glu Xaa Ser Pro Ser Xaa Glu Glu Ile Xaa Leu Ser Glu Ser Asp 
                485                 490                 495     


Asn Ala Lys Glu Ser Ile 
            500         


<210> 1756
<211> 1469
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1058)..(1058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1138)..(1138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1197)..(1197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1360)..(1360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1366)..(1366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1467)..(1467)
<223> Selenocysteine

<400> 1756
Met Ala Arg Leu Ala Ala Val Leu Trp Asn Leu Cys Val Xaa Ala Val 
1               5                   10                  15      


Leu Val Xaa Ser Ala Xaa Gln Gly Leu Ser Arg Ala Gly Leu Pro Phe 
            20                  25                  30          


Gly Leu Met Arg Arg Glu Leu Ala Cys Glu Gly Tyr Pro Ile Glu Leu 
        35                  40                  45              


Arg Cys Pro Gly Ser Asp Val Ile Met Val Glu Asn Ala Asn Tyr Gly 
    50                  55                  60                  


Arg Xaa Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu Asn 
65                  70                  75                  80  


Val Gln Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Ser Gln Arg Cys 
                85                  90                  95      


Asn Asn Arg Xaa Gln Cys Val Val Val Ala Gly Ser Asp Ala Phe Pro 
            100                 105                 110         


Asp Pro Cys Pro Gly Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Asp Cys 
        115                 120                 125             


Val Pro Tyr Ile Phe Val Cys Pro Gly Xaa Leu Gln Lys Val Leu Glu 
    130                 135                 140                 


Pro Xaa Ser Xaa His Glu Ser Glu His Gln Ser Gly Ala Trp Cys Lys 
145                 150                 155                 160 


Asp Pro Leu Gln Ala Gly Asp Arg Ile Tyr Val Met Pro Trp Ile Pro 
                165                 170                 175     


Tyr Arg Xaa Asp Xaa Leu Xaa Glu Tyr Ala Ser Trp Glu Asp Tyr Val 
            180                 185                 190         


Ala Ala Arg His Xaa Xaa Xaa Tyr Arg Leu Pro Asn Arg Val Asp Gly 
        195                 200                 205             


Xaa Gly Phe Val Val Tyr Asp Gly Ala Val Phe Tyr Asn Lys Glu Arg 
    210                 215                 220                 


Xaa Arg Asn Ile Val Lys Tyr Asp Leu Arg Xaa Arg Ile Lys Ser Gly 
225                 230                 235                 240 


Glu Xaa Val Ile Asn Xaa Ala Asn Tyr His Asp Xaa Ser Pro Tyr Arg 
                245                 250                 255     


Trp Gly Gly Lys Xaa Asp Ile Asp Leu Ala Val Asp Glu Asn Gly Leu 
            260                 265                 270         


Trp Val Ile Tyr Ala Xaa Glu Gly Asn Asn Gly Arg Leu Val Val Ser 
        275                 280                 285             


Gln Leu Asn Pro Tyr Xaa Leu Arg Phe Glu Gly Xaa Trp Glu Xaa Gly 
    290                 295                 300                 


Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Val Cys Gly Val Leu 
305                 310                 315                 320 


Tyr Val Leu Arg Ser Val Tyr Val Asp Asp Asp Ser Glu Ala Ala Gly 
                325                 330                 335     


Asn Arg Val Asp Tyr Ala Phe Asn Xaa Asn Ala Asn Arg Glu Glu Pro 
            340                 345                 350         


Val Ser Leu Xaa Phe Pro Asn Pro Tyr Gln Phe Ile Ser Ser Val Asp 
        355                 360                 365             


Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp Asn Asn Tyr Phe Val 
    370                 375                 380                 


Val Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp Pro Ser Ala Gly Pro 
385                 390                 395                 400 


Ala Xaa Ser Pro Pro Leu Ser Xaa Xaa Xaa Xaa Ala Arg Pro Xaa Pro 
                405                 410                 415     


Leu Xaa Ser Xaa Ala Ser Pro Ala Ala Xaa Xaa Pro Leu Arg Arg Ala 
            420                 425                 430         


Pro Leu Xaa Xaa His Pro Val Gly Ala Ile Asn Gln Leu Gly Pro Asp 
        435                 440                 445             


Leu Pro Pro Ala Xaa Ala Pro Val Pro Ser Xaa Arg Arg Pro Pro Ala 
    450                 455                 460                 


Pro Asn Leu His Val Ser Pro Glu Leu Phe Cys Glu Pro Arg Glu Val 
465                 470                 475                 480 


Arg Arg Val Gln Trp Pro Ala Xaa Gln Gln Gly Met Leu Val Glu Arg 
                485                 490                 495     


Pro Cys Pro Lys Gly Xaa Arg Gly Ile Ala Ser Phe Gln Cys Leu Pro 
            500                 505                 510         


Ala Leu Gly Leu Trp Asn Pro Arg Gly Pro Asp Leu Ser Asn Cys Xaa 
        515                 520                 525             


Ser Pro Trp Val Asn Gln Val Ala Gln Lys Ile Lys Ser Gly Glu Asn 
    530                 535                 540                 


Ala Ala Asn Ile Ala Ser Glu Leu Ala Arg His Xaa Arg Gly Ser Ile 
545                 550                 555                 560 


Tyr Ala Gly Asp Val Ser Ser Ser Val Lys Leu Met Glu Gln Leu Leu 
                565                 570                 575     


Asp Ile Leu Asp Ala Gln Leu Gln Ala Leu Arg Pro Ile Glu Arg Glu 
            580                 585                 590         


Ser Ala Gly Lys Asn Tyr Asn Lys Met His Lys Arg Glu Arg Xaa Cys 
        595                 600                 605             


Lys Asp Tyr Ile Lys Ala Val Val Glu Xaa Val Asp Asn Leu Leu Arg 
    610                 615                 620                 


Pro Glu Ala Leu Glu Ser Trp Lys Asp Met Asn Ala Xaa Glu Gln Val 
625                 630                 635                 640 


His Xaa Ala Xaa Met Leu Leu Asp Val Leu Glu Glu Gly Ala Phe Leu 
                645                 650                 655     


Leu Ala Asp Asn Val Arg Glu Pro Ala Arg Phe Leu Ala Ala Lys Glu 
            660                 665                 670         


Asn Val Val Leu Glu Val Xaa Val Leu Asn Xaa Glu Gly Gln Val Gln 
        675                 680                 685             


Glu Leu Val Phe Pro Gln Glu Glu Tyr Pro Arg Lys Asn Ser Ile Gln 
    690                 695                 700                 


Leu Ser Ala Lys Xaa Ile Lys Gln Asn Ser Arg Asn Gly Val Val Lys 
705                 710                 715                 720 


Val Val Phe Ile Leu Tyr Asn Asn Leu Gly Leu Phe Leu Ser Xaa Glu 
                725                 730                 735     


Asn Ala Xaa Val Lys Leu Ala Gly Glu Ala Gly Pro Gly Gly Pro Gly 
            740                 745                 750         


Gly Ala Ser Leu Val Val Asn Ser Gln Val Ile Ala Ala Ser Ile Asn 
        755                 760                 765             


Lys Glu Ser Ser Arg Val Phe Leu Met Asp Pro Val Ile Phe Xaa Val 
    770                 775                 780                 


Ala His Leu Glu Asp Lys Asn His Phe Asn Ala Asn Cys Ser Phe Trp 
785                 790                 795                 800 


Asn Tyr Ser Glu Arg Ser Met Leu Gly Tyr Trp Ser Xaa Gln Gly Cys 
                805                 810                 815     


Arg Leu Val Glu Ser Asn Lys Xaa His Xaa Xaa Cys Ala Cys Ser His 
            820                 825                 830         


Leu Xaa Asn Phe Ala Val Leu Met Ala His Arg Glu Ile Tyr Gln Gly 
        835                 840                 845             


Arg Ile Asn Glu Leu Leu Leu Ser Val Ile Xaa Trp Val Gly Ile Val 
    850                 855                 860                 


Ile Ser Leu Val Cys Leu Ala Ile Cys Ile Ser Xaa Phe Cys Phe Leu 
865                 870                 875                 880 


Arg Gly Leu Gln Xaa Asp Arg Asn Xaa Ile His Lys Asn Leu Cys Ile 
                885                 890                 895     


Asn Leu Phe Leu Ala Glu Leu Leu Phe Leu Val Gly Ile Asp Lys Xaa 
            900                 905                 910         


Gln Tyr Glu Ile Ala Cys Pro Ile Phe Ala Gly Leu Leu His Tyr Phe 
        915                 920                 925             


Phe Leu Ala Ala Phe Ser Trp Leu Cys Leu Glu Gly Val His Leu Tyr 
    930                 935                 940                 


Leu Leu Leu Val Glu Val Phe Glu Ser Glu Tyr Ser Arg Xaa Lys Tyr 
945                 950                 955                 960 


Tyr Tyr Leu Gly Gly Tyr Cys Phe Pro Ala Leu Val Val Gly Ile Ala 
                965                 970                 975     


Ala Ala Ile Asp Tyr Arg Ser Tyr Gly Xaa Glu Lys Ala Cys Trp Leu 
            980                 985                 990         


Arg Val Asp Asn Tyr Phe Ile Trp  Ser Phe Ile Gly Pro  Val Ser Phe 
        995                 1000                 1005             


Val Ile  Val Val Asn Leu Val  Phe Leu Met Val Xaa  Leu His Lys 
    1010                 1015                 1020             


Met Ile  Arg Ser Ser Ser Val  Leu Lys Pro Asp Ser  Ser Arg Leu 
    1025                 1030                 1035             


Asp Asn  Ile Lys Ser Trp Ala  Leu Gly Ala Ile Ala  Leu Leu Phe 
    1040                 1045                 1050             


Leu Leu  Gly Leu Xaa Trp Ala  Phe Gly Leu Leu Phe  Ile Asn Lys 
    1055                 1060                 1065             


Glu Ser  Val Val Met Ala Tyr  Leu Phe Xaa Xaa Phe  Asn Ala Phe 
    1070                 1075                 1080             


Gln Gly  Val Phe Ile Phe Val  Phe His Cys Ala Leu  Gln Lys Lys 
    1085                 1090                 1095             


Val His  Lys Glu Tyr Ser Lys  Cys Leu Arg His Ser  Tyr Cys Cys 
    1100                 1105                 1110             


Ile Arg  Ser Pro Pro Gly Gly  Xaa His Gly Ser Leu  Lys Xaa Ser 
    1115                 1120                 1125             


Ala Met  Arg Ser Asn Xaa Arg  Tyr Tyr Xaa Gly Xaa  Gln Ser Arg 
    1130                 1135                 1140             


Ile Arg  Arg Met Trp Asn Asp  Xaa Val Arg Lys Gln  Xaa Glu Ser 
    1145                 1150                 1155             


Ser Phe  Met Ala Gly Asp Ile  Asn Ser Xaa Pro Xaa  Leu Asn Arg 
    1160                 1165                 1170             


Gly Xaa  Met Gly Asn His Leu  Leu Xaa Asn Pro Val  Leu Gln Pro 
    1175                 1180                 1185             


Arg Gly  Gly Xaa Ser Pro Tyr  Asn Xaa Leu Ile Ala  Glu Ser Val 
    1190                 1195                 1200             


Gly Phe  Asn Pro Ser Ser Pro  Pro Val Phe Asn Ser  Pro Gly Ser 
    1205                 1210                 1215             


Tyr Arg  Glu Pro Lys His Pro  Leu Gly Gly Arg Glu  Ala Cys Gly 
    1220                 1225                 1230             


Met Asp  Xaa Leu Pro Leu Asn  Gly Asn Phe Asn Asn  Ser Tyr Ser 
    1235                 1240                 1245             


Leu Arg  Ser Gly Asp Phe Pro  Pro Gly Asp Gly Gly  Pro Glu Pro 
    1250                 1255                 1260             


Pro Arg  Gly Arg Asn Leu Ala  Asp Ala Ala Ala Phe  Glu Lys Met 
    1265                 1270                 1275             


Ile Ile  Ser Glu Leu Val His  Asn Asn Leu Arg Gly  Ser Ser Ser 
    1280                 1285                 1290             


Ala Ala  Lys Gly Pro Pro Pro  Pro Glu Pro Pro Val  Pro Pro Val 
    1295                 1300                 1305             


Pro Gly  Gly Gly Gly Glu Glu  Glu Ala Gly Gly Pro  Gly Gly Ala 
    1310                 1315                 1320             


Asp Arg  Ala Glu Ile Glu Leu  Leu Tyr Lys Ala Leu  Glu Glu Pro 
    1325                 1330                 1335             


Leu Leu  Leu Pro Arg Ala Gln  Ser Val Leu Tyr Gln  Ser Asp Leu 
    1340                 1345                 1350             


Asp Glu  Ser Glu Ser Cys Xaa  Ala Glu Asp Gly Ala  Xaa Ser Arg 
    1355                 1360                 1365             


Pro Leu  Ser Ser Pro Pro Gly  Arg Asp Ser Leu Tyr  Ala Ser Gly 
    1370                 1375                 1380             


Ala Asn  Leu Arg Asp Ser Pro  Ser Tyr Pro Asp Ser  Ser Pro Glu 
    1385                 1390                 1395             


Gly Pro  Ser Glu Ala Leu Pro  Pro Pro Pro Pro Ala  Pro Pro Gly 
    1400                 1405                 1410             


Pro Pro  Glu Ile Tyr Tyr Xaa  Ser Arg Pro Pro Ala  Leu Val Ala 
    1415                 1420                 1425             


Arg Asn  Pro Leu Gln Gly Tyr  Tyr Gln Val Arg Arg  Pro Ser His 
    1430                 1435                 1440             


Glu Gly  Tyr Leu Ala Ala Pro  Gly Leu Glu Gly Pro  Gly Pro Asp 
    1445                 1450                 1455             


Gly Asp  Gly Gln Met Gln Leu  Val Xaa Ser Leu 
    1460                 1465                 


<210> 1757
<211> 1474
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1083)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1145)..(1145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1161)..(1161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1173)..(1173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1187)..(1187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1197)..(1197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1365)..(1365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1425)..(1425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<400> 1757
Met Ala Arg Leu Ala Ala Val Leu Trp Asn Leu Cys Val Xaa Ala Val 
1               5                   10                  15      


Leu Val Xaa Ser Ala Xaa Gln Gly Leu Ser Arg Ala Gly Leu Pro Phe 
            20                  25                  30          


Gly Leu Met Arg Arg Glu Leu Ala Cys Glu Gly Tyr Pro Ile Glu Leu 
        35                  40                  45              


Arg Cys Pro Gly Ser Asp Val Ile Met Val Glu Asn Ala Asn Tyr Gly 
    50                  55                  60                  


Arg Xaa Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu Asn 
65                  70                  75                  80  


Val Gln Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Ser Gln Arg Cys 
                85                  90                  95      


Asn Asn Arg Xaa Gln Cys Val Val Val Ala Gly Ser Asp Ala Phe Pro 
            100                 105                 110         


Asp Pro Cys Pro Gly Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Asp Cys 
        115                 120                 125             


Val Pro Tyr Lys Val Glu Gln Lys Val Phe Val Cys Pro Gly Xaa Leu 
    130                 135                 140                 


Gln Lys Val Leu Glu Pro Xaa Ser Xaa His Glu Ser Glu His Gln Ser 
145                 150                 155                 160 


Gly Ala Trp Cys Lys Asp Pro Leu Gln Ala Gly Asp Arg Ile Tyr Val 
                165                 170                 175     


Met Pro Trp Ile Pro Tyr Arg Xaa Asp Xaa Leu Xaa Glu Tyr Ala Ser 
            180                 185                 190         


Trp Glu Asp Tyr Val Ala Ala Arg His Xaa Xaa Xaa Tyr Arg Leu Pro 
        195                 200                 205             


Asn Arg Val Asp Gly Xaa Gly Phe Val Val Tyr Asp Gly Ala Val Phe 
    210                 215                 220                 


Tyr Asn Lys Glu Arg Xaa Arg Asn Ile Val Lys Tyr Asp Leu Arg Xaa 
225                 230                 235                 240 


Arg Ile Lys Ser Gly Glu Xaa Val Ile Asn Xaa Ala Asn Tyr His Asp 
                245                 250                 255     


Xaa Ser Pro Tyr Arg Trp Gly Gly Lys Xaa Asp Ile Asp Leu Ala Val 
            260                 265                 270         


Asp Glu Asn Gly Leu Trp Val Ile Tyr Ala Xaa Glu Gly Asn Asn Gly 
        275                 280                 285             


Arg Leu Val Val Ser Gln Leu Asn Pro Tyr Xaa Leu Arg Phe Glu Gly 
    290                 295                 300                 


Xaa Trp Glu Xaa Gly Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met 
305                 310                 315                 320 


Val Cys Gly Val Leu Tyr Val Leu Arg Ser Val Tyr Val Asp Asp Asp 
                325                 330                 335     


Ser Glu Ala Ala Gly Asn Arg Val Asp Tyr Ala Phe Asn Xaa Asn Ala 
            340                 345                 350         


Asn Arg Glu Glu Pro Val Ser Leu Xaa Phe Pro Asn Pro Tyr Gln Phe 
        355                 360                 365             


Ile Ser Ser Val Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp 
    370                 375                 380                 


Asn Asn Tyr Phe Val Val Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp 
385                 390                 395                 400 


Pro Ser Ala Gly Pro Ala Xaa Ser Pro Pro Leu Ser Xaa Xaa Xaa Xaa 
                405                 410                 415     


Ala Arg Pro Xaa Pro Leu Xaa Ser Xaa Ala Ser Pro Ala Ala Xaa Xaa 
            420                 425                 430         


Pro Leu Arg Arg Ala Pro Leu Xaa Xaa His Pro Val Gly Ala Ile Asn 
        435                 440                 445             


Gln Leu Gly Pro Asp Leu Pro Pro Ala Xaa Ala Pro Val Pro Ser Xaa 
    450                 455                 460                 


Arg Arg Pro Pro Ala Pro Asn Leu His Val Ser Pro Glu Leu Phe Cys 
465                 470                 475                 480 


Glu Pro Arg Glu Val Arg Arg Val Gln Trp Pro Ala Xaa Gln Gln Gly 
                485                 490                 495     


Met Leu Val Glu Arg Pro Cys Pro Lys Gly Xaa Arg Gly Ile Ala Ser 
            500                 505                 510         


Phe Gln Cys Leu Pro Ala Leu Gly Leu Trp Asn Pro Arg Gly Pro Asp 
        515                 520                 525             


Leu Ser Asn Cys Xaa Ser Pro Trp Val Asn Gln Val Ala Gln Lys Ile 
    530                 535                 540                 


Lys Ser Gly Glu Asn Ala Ala Asn Ile Ala Ser Glu Leu Ala Arg His 
545                 550                 555                 560 


Xaa Arg Gly Ser Ile Tyr Ala Gly Asp Val Ser Ser Ser Val Lys Leu 
                565                 570                 575     


Met Glu Gln Leu Leu Asp Ile Leu Asp Ala Gln Leu Gln Ala Leu Arg 
            580                 585                 590         


Pro Ile Glu Arg Glu Ser Ala Gly Lys Asn Tyr Asn Lys Met His Lys 
        595                 600                 605             


Arg Glu Arg Xaa Cys Lys Asp Tyr Ile Lys Ala Val Val Glu Xaa Val 
    610                 615                 620                 


Asp Asn Leu Leu Arg Pro Glu Ala Leu Glu Ser Trp Lys Asp Met Asn 
625                 630                 635                 640 


Ala Xaa Glu Gln Val His Xaa Ala Xaa Met Leu Leu Asp Val Leu Glu 
                645                 650                 655     


Glu Gly Ala Phe Leu Leu Ala Asp Asn Val Arg Glu Pro Ala Arg Phe 
            660                 665                 670         


Leu Ala Ala Lys Glu Asn Val Val Leu Glu Val Xaa Val Leu Asn Xaa 
        675                 680                 685             


Glu Gly Gln Val Gln Glu Leu Val Phe Pro Gln Glu Glu Tyr Pro Arg 
    690                 695                 700                 


Lys Asn Ser Ile Gln Leu Ser Ala Lys Xaa Ile Lys Gln Asn Ser Arg 
705                 710                 715                 720 


Asn Gly Val Val Lys Val Val Phe Ile Leu Tyr Asn Asn Leu Gly Leu 
                725                 730                 735     


Phe Leu Ser Xaa Glu Asn Ala Xaa Val Lys Leu Ala Gly Glu Ala Gly 
            740                 745                 750         


Pro Gly Gly Pro Gly Gly Ala Ser Leu Val Val Asn Ser Gln Val Ile 
        755                 760                 765             


Ala Ala Ser Ile Asn Lys Glu Ser Ser Arg Val Phe Leu Met Asp Pro 
    770                 775                 780                 


Val Ile Phe Xaa Val Ala His Leu Glu Asp Lys Asn His Phe Asn Ala 
785                 790                 795                 800 


Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg Ser Met Leu Gly Tyr Trp 
                805                 810                 815     


Ser Xaa Gln Gly Cys Arg Leu Val Glu Ser Asn Lys Xaa His Xaa Xaa 
            820                 825                 830         


Cys Ala Cys Ser His Leu Xaa Asn Phe Ala Val Leu Met Ala His Arg 
        835                 840                 845             


Glu Ile Tyr Gln Gly Arg Ile Asn Glu Leu Leu Leu Ser Val Ile Xaa 
    850                 855                 860                 


Trp Val Gly Ile Val Ile Ser Leu Val Cys Leu Ala Ile Cys Ile Ser 
865                 870                 875                 880 


Xaa Phe Cys Phe Leu Arg Gly Leu Gln Xaa Asp Arg Asn Xaa Ile His 
                885                 890                 895     


Lys Asn Leu Cys Ile Asn Leu Phe Leu Ala Glu Leu Leu Phe Leu Val 
            900                 905                 910         


Gly Ile Asp Lys Xaa Gln Tyr Glu Ile Ala Cys Pro Ile Phe Ala Gly 
        915                 920                 925             


Leu Leu His Tyr Phe Phe Leu Ala Ala Phe Ser Trp Leu Cys Leu Glu 
    930                 935                 940                 


Gly Val His Leu Tyr Leu Leu Leu Val Glu Val Phe Glu Ser Glu Tyr 
945                 950                 955                 960 


Ser Arg Xaa Lys Tyr Tyr Tyr Leu Gly Gly Tyr Cys Phe Pro Ala Leu 
                965                 970                 975     


Val Val Gly Ile Ala Ala Ala Ile Asp Tyr Arg Ser Tyr Gly Xaa Glu 
            980                 985                 990         


Lys Ala Cys Trp Leu Arg Val Asp  Asn Tyr Phe Ile Trp  Ser Phe Ile 
        995                 1000                 1005             


Gly Pro  Val Ser Phe Val Ile  Val Val Asn Leu Val  Phe Leu Met 
    1010                 1015                 1020             


Val Xaa  Leu His Lys Met Ile  Arg Ser Ser Ser Val  Leu Lys Pro 
    1025                 1030                 1035             


Asp Ser  Ser Arg Leu Asp Asn  Ile Lys Ser Trp Ala  Leu Gly Ala 
    1040                 1045                 1050             


Ile Ala  Leu Leu Phe Leu Leu  Gly Leu Xaa Trp Ala  Phe Gly Leu 
    1055                 1060                 1065             


Leu Phe  Ile Asn Lys Glu Ser  Val Val Met Ala Tyr  Leu Phe Xaa 
    1070                 1075                 1080             


Xaa Phe  Asn Ala Phe Gln Gly  Val Phe Ile Phe Val  Phe His Cys 
    1085                 1090                 1095             


Ala Leu  Gln Lys Lys Val His  Lys Glu Tyr Ser Lys  Cys Leu Arg 
    1100                 1105                 1110             


His Ser  Tyr Cys Cys Ile Arg  Ser Pro Pro Gly Gly  Xaa His Gly 
    1115                 1120                 1125             


Ser Leu  Lys Xaa Ser Ala Met  Arg Ser Asn Xaa Arg  Tyr Tyr Xaa 
    1130                 1135                 1140             


Gly Xaa  Gln Ser Arg Ile Arg  Arg Met Trp Asn Asp  Xaa Val Arg 
    1145                 1150                 1155             


Lys Gln  Xaa Glu Ser Ser Phe  Met Ala Gly Asp Ile  Asn Ser Xaa 
    1160                 1165                 1170             


Pro Xaa  Leu Asn Arg Gly Xaa  Met Gly Asn His Leu  Leu Xaa Asn 
    1175                 1180                 1185             


Pro Val  Leu Gln Pro Arg Gly  Gly Xaa Ser Pro Tyr  Asn Xaa Leu 
    1190                 1195                 1200             


Ile Ala  Glu Ser Val Gly Phe  Asn Pro Ser Ser Pro  Pro Val Phe 
    1205                 1210                 1215             


Asn Ser  Pro Gly Ser Tyr Arg  Glu Pro Lys His Pro  Leu Gly Gly 
    1220                 1225                 1230             


Arg Glu  Ala Cys Gly Met Asp  Xaa Leu Pro Leu Asn  Gly Asn Phe 
    1235                 1240                 1245             


Asn Asn  Ser Tyr Ser Leu Arg  Ser Gly Asp Phe Pro  Pro Gly Asp 
    1250                 1255                 1260             


Gly Gly  Pro Glu Pro Pro Arg  Gly Arg Asn Leu Ala  Asp Ala Ala 
    1265                 1270                 1275             


Ala Phe  Glu Lys Met Ile Ile  Ser Glu Leu Val His  Asn Asn Leu 
    1280                 1285                 1290             


Arg Gly  Ser Ser Ser Ala Ala  Lys Gly Pro Pro Pro  Pro Glu Pro 
    1295                 1300                 1305             


Pro Val  Pro Pro Val Pro Gly  Gly Gly Gly Glu Glu  Glu Ala Gly 
    1310                 1315                 1320             


Gly Pro  Gly Gly Ala Asp Arg  Ala Glu Ile Glu Leu  Leu Tyr Lys 
    1325                 1330                 1335             


Ala Leu  Glu Glu Pro Leu Leu  Leu Pro Arg Ala Gln  Ser Val Leu 
    1340                 1345                 1350             


Tyr Gln  Ser Asp Leu Asp Glu  Ser Glu Ser Cys Xaa  Ala Glu Asp 
    1355                 1360                 1365             


Gly Ala  Xaa Ser Arg Pro Leu  Ser Ser Pro Pro Gly  Arg Asp Ser 
    1370                 1375                 1380             


Leu Tyr  Ala Ser Gly Ala Asn  Leu Arg Asp Ser Pro  Ser Tyr Pro 
    1385                 1390                 1395             


Asp Ser  Ser Pro Glu Gly Pro  Ser Glu Ala Leu Pro  Pro Pro Pro 
    1400                 1405                 1410             


Pro Ala  Pro Pro Gly Pro Pro  Glu Ile Tyr Tyr Xaa  Ser Arg Pro 
    1415                 1420                 1425             


Pro Ala  Leu Val Ala Arg Asn  Pro Leu Gln Gly Tyr  Tyr Gln Val 
    1430                 1435                 1440             


Arg Arg  Pro Ser His Glu Gly  Tyr Leu Ala Ala Pro  Gly Leu Glu 
    1445                 1450                 1455             


Gly Pro  Gly Pro Asp Gly Asp  Gly Gln Met Gln Leu  Val Xaa Ser 
    1460                 1465                 1470             


Leu 
    


<210> 1758
<211> 225
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<400> 1758
Ser Ala Gly His Pro Ser Pro Arg Xaa Gln Trp Val Pro Ser Xaa Ser 
1               5                   10                  15      


Trp Asp Leu Ile Cys Leu Gln Pro Gln Pro Gln Ser Pro Ala Pro Gly 
            20                  25                  30          


Gly Pro Gln Pro Arg Ile Tyr Xaa Cys Pro Leu Ser Ser Ser Ala Ser 
        35                  40                  45              


Pro Glu Arg Tyr Gly Gly Ser Ser Gly Arg Pro Pro Ser Arg Ala Cys 
    50                  55                  60                  


Trp Trp Arg Gly Pro Ala Pro Arg Gly Leu Glu Ile Lys Ser Gly Glu 
65                  70                  75                  80  


Asn Ala Ala Asn Ile Ala Ser Glu Leu Ala Arg His Xaa Arg Gly Ser 
                85                  90                  95      


Ile Tyr Ala Gly Asp Val Ser Ser Ser Val Lys Leu Met Glu Gln Leu 
            100                 105                 110         


Leu Asp Ile Leu Asp Ala Gln Leu Gln Ala Leu Arg Pro Ile Glu Arg 
        115                 120                 125             


Glu Ser Ala Gly Lys Asn Tyr Asn Lys Met His Lys Arg Glu Arg Xaa 
    130                 135                 140                 


Cys Lys Asp Tyr Ile Lys Ala Val Val Glu Xaa Val Asp Asn Leu Leu 
145                 150                 155                 160 


Arg Pro Glu Ala Leu Glu Ser Trp Lys Asp Met Asn Ala Xaa Glu Gln 
                165                 170                 175     


Val His Xaa Ala Xaa Met Leu Leu Asp Val Leu Glu Glu Gly Ala Phe 
            180                 185                 190         


Leu Leu Ala Asp Asn Val Arg Glu Pro Ala Arg Phe Leu Ala Ala Lys 
        195                 200                 205             


Glu Asn Val Val Leu Glu Val Xaa Val Leu Asn Xaa Glu Gly Gln Val 
    210                 215                 220                 


Gln 
225 


<210> 1759
<211> 264
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<400> 1759
Xaa Gly Xaa His Gly Ser Leu Lys Xaa Ser Ala Met Arg Ser Asn Xaa 
1               5                   10                  15      


Arg Tyr Tyr Xaa Gly Xaa Gln Ser Arg Ile Arg Arg Met Trp Asn Asp 
            20                  25                  30          


Xaa Val Arg Lys Gln Xaa Glu Ser Ser Phe Met Ala Gly Asp Ile Asn 
        35                  40                  45              


Ser Xaa Pro Xaa Leu Asn Arg Gly Xaa Met Gly Asn His Leu Leu Xaa 
    50                  55                  60                  


Asn Pro Val Leu Gln Pro Arg Gly Gly Xaa Ser Pro Tyr Asn Xaa Leu 
65                  70                  75                  80  


Ile Ala Glu Ser Val Gly Phe Asn Pro Ser Ser Pro Pro Val Phe Asn 
                85                  90                  95      


Ser Pro Glu Leu Glu Pro Gly Leu Ala Phe Arg Ala His Pro Cys Leu 
            100                 105                 110         


Phe Ser Ser Leu Phe Trp Leu Pro Pro Ala Gly Ser Tyr Arg Glu Pro 
        115                 120                 125             


Lys His Pro Leu Gly Gly Arg Glu Ala Cys Gly Met Asp Xaa Leu Pro 
    130                 135                 140                 


Leu Asn Gly Asn Phe Asn Asn Ser Tyr Ser Leu Arg Ser Gly Asp Phe 
145                 150                 155                 160 


Pro Pro Gly Asp Gly Gly Pro Glu Pro Pro Arg Gly Arg Asn Leu Ala 
                165                 170                 175     


Asp Ala Ala Ala Phe Glu Lys Met Ile Ile Ser Glu Leu Val His Asn 
            180                 185                 190         


Asn Leu Arg Gly Ser Ser Ser Ala Ala Lys Gly Pro Pro Pro Pro Glu 
        195                 200                 205             


Pro Pro Val Pro Pro Val Pro Gly Gly Gly Gly Glu Glu Glu Ala Gly 
    210                 215                 220                 


Gly Pro Gly Gly Ala Asp Arg Ala Glu Ile Glu Leu Leu Tyr Lys Ala 
225                 230                 235                 240 


Leu Glu Glu Pro Leu Leu Leu Pro Arg Ala Gln Ser Val Leu Tyr Gln 
                245                 250                 255     


Ser Asp Leu Asp Glu Ser Glu Ser 
            260                 


<210> 1760
<211> 243
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<400> 1760
Xaa Ser Leu Lys Xaa Ser Ala Met Arg Ser Asn Xaa Arg Tyr Tyr Xaa 
1               5                   10                  15      


Gly Xaa Gln Ser Arg Ile Arg Arg Met Trp Asn Asp Xaa Val Arg Lys 
            20                  25                  30          


Gln Xaa Glu Ser Ser Phe Met Ala Gly Asp Ile Asn Ser Xaa Pro Xaa 
        35                  40                  45              


Leu Asn Arg Gly Xaa Met Gly Asn His Leu Leu Xaa Asn Pro Val Leu 
    50                  55                  60                  


Gln Pro Arg Gly Gly Xaa Ser Pro Tyr Asn Xaa Leu Ile Ala Glu Ser 
65                  70                  75                  80  


Val Gly Phe Asn Pro Ser Ser Pro Pro Val Phe Asn Ser Pro Glu His 
                85                  90                  95      


Pro Leu Gly Gly Arg Glu Ala Cys Gly Met Asp Xaa Leu Pro Leu Asn 
            100                 105                 110         


Gly Asn Phe Asn Asn Ser Tyr Ser Leu Arg Ser Gly Asp Phe Pro Pro 
        115                 120                 125             


Gly Asp Gly Gly Pro Glu Pro Pro Arg Gly Arg Asn Leu Ala Asp Ala 
    130                 135                 140                 


Ala Ala Phe Glu Lys Met Ile Ile Ser Glu Leu Val His Asn Asn Leu 
145                 150                 155                 160 


Arg Gly Ser Ser Ser Ala Ala Lys Gly Pro Pro Pro Pro Glu Pro Pro 
                165                 170                 175     


Val Pro Pro Val Pro Gly Gly Gly Gly Glu Glu Glu Ala Gly Gly Pro 
            180                 185                 190         


Gly Gly Ala Asp Arg Ala Glu Ile Glu Leu Leu Tyr Lys Ala Leu Glu 
        195                 200                 205             


Glu Pro Leu Leu Leu Pro Arg Ala Gln Ser Val Leu Tyr Gln Ser Asp 
    210                 215                 220                 


Leu Asp Glu Ser Glu Ser Cys Xaa Ala Glu Asp Gly Ala Xaa Ser Arg 
225                 230                 235                 240 


Pro Leu Ser 
            


<210> 1761
<211> 1123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1108)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<400> 1761
Met Val Ser Ser Gly Cys Arg Met Arg Ser Leu Trp Phe Ile Ile Val 
1               5                   10                  15      


Ile Ser Phe Leu Pro Asn Xaa Glu Gly Phe Ser Arg Ala Ala Leu Pro 
            20                  25                  30          


Phe Gly Leu Val Arg Arg Glu Leu Ser Cys Glu Gly Tyr Ser Ile Asp 
        35                  40                  45              


Leu Arg Cys Pro Gly Ser Asp Val Ile Met Ile Glu Ser Ala Asn Tyr 
    50                  55                  60                  


Gly Arg Xaa Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu 
65                  70                  75                  80  


Asn Xaa Asp Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Xaa Gln Arg 
                85                  90                  95      


Cys Asn Asn Arg Xaa Gln Cys Ile Val Val Xaa Gly Ser Asp Val Phe 
            100                 105                 110         


Pro Asp Pro Cys Pro Gly Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu 
        115                 120                 125             


Cys Val Pro Tyr Ile Phe Val Cys Pro Gly Xaa Leu Lys Ala Ile Val 
    130                 135                 140                 


Asp Ser Pro Cys Ile Tyr Glu Ala Glu Gln Lys Ala Gly Ala Trp Cys 
145                 150                 155                 160 


Lys Asp Pro Leu Gln Ala Ala Asp Lys Ile Tyr Phe Met Pro Trp Xaa 
                165                 170                 175     


Pro Tyr Arg Xaa Asp Xaa Leu Ile Glu Tyr Ala Ser Leu Glu Asp Phe 
            180                 185                 190         


Gln Asn Ser Arg Gln Xaa Xaa Xaa Tyr Lys Leu Pro Asn Arg Val Asp 
        195                 200                 205             


Gly Xaa Gly Phe Val Val Tyr Asp Gly Ala Val Phe Phe Asn Lys Glu 
    210                 215                 220                 


Arg Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg Ile Lys Ser 
225                 230                 235                 240 


Gly Glu Ala Ile Ile Asn Tyr Ala Asn Tyr His Asp Xaa Ser Pro Tyr 
                245                 250                 255     


Arg Trp Gly Gly Lys Xaa Asp Ile Asp Leu Ala Val Asp Glu Asn Gly 
            260                 265                 270         


Leu Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Met Ile Val Ile 
        275                 280                 285             


Ser Gln Leu Asn Pro Tyr Xaa Leu Arg Phe Glu Ala Xaa Trp Glu Xaa 
    290                 295                 300                 


Val Tyr Asp Lys Arg Ala Ala Ser Asn Ala Phe Met Ile Cys Gly Val 
305                 310                 315                 320 


Leu Tyr Val Val Arg Ser Val Tyr Gln Asp Asn Glu Ser Glu Xaa Gly 
                325                 330                 335     


Lys Asn Ser Ile Asp Tyr Ile Tyr Asn Xaa Arg Leu Asn Arg Gly Glu 
            340                 345                 350         


Tyr Val Asp Val Pro Phe Pro Asn Gln Tyr Gln Tyr Ile Ala Ala Val 
        355                 360                 365             


Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp Asn Asn Asn Phe 
    370                 375                 380                 


Ile Leu Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp Pro Ala Gln Val 
385                 390                 395                 400 


Pro Xaa Xaa Ala Val Xaa Ile Xaa Ser Ser Ala Glu Leu Phe Lys Xaa 
                405                 410                 415     


Ile Ile Ser Xaa Xaa Ser Xaa Xaa Ser Gln Lys Gly Pro Met Ser Xaa 
            420                 425                 430         


Xaa Val Ala Gly Ser Gln Glu Gly Ser Lys Gly Xaa Lys Pro Pro Pro 
        435                 440                 445             


Ala Val Ser Xaa Xaa Lys Ile Pro Pro Ile Xaa Asn Ile Phe Pro Leu 
    450                 455                 460                 


Pro Glu Arg Phe Cys Glu Ala Leu Asp Ser Lys Gly Ile Lys Trp Pro 
465                 470                 475                 480 


Gln Xaa Gln Arg Gly Met Met Val Glu Arg Pro Cys Pro Lys Gly Xaa 
                485                 490                 495     


Arg Gly Xaa Ala Ser Tyr Leu Cys Met Ile Ser Xaa Gly Xaa Trp Asn 
            500                 505                 510         


Pro Lys Gly Pro Asp Leu Ser Asn Cys Xaa Ser His Trp Val Asn Gln 
        515                 520                 525             


Leu Ala Gln Lys Ile Arg Ser Gly Glu Asn Ala Ala Ser Leu Ala Asn 
    530                 535                 540                 


Glu Leu Ala Lys His Xaa Lys Gly Pro Val Phe Ala Gly Asp Val Ser 
545                 550                 555                 560 


Ser Ser Val Arg Leu Met Glu Gln Leu Val Asp Ile Leu Asp Ala Gln 
                565                 570                 575     


Leu Gln Glu Leu Lys Pro Ser Glu Lys Asp Ser Ala Gly Arg Ser Tyr 
            580                 585                 590         


Asn Lys Ala Ile Val Asp Xaa Val Asp Asn Leu Leu Arg Pro Glu Ala 
        595                 600                 605             


Leu Glu Ser Trp Lys His Met Asn Ser Ser Glu Gln Ala His Xaa Ala 
    610                 615                 620                 


Xaa Met Leu Leu Asp Xaa Leu Glu Glu Gly Ala Phe Val Leu Ala Asp 
625                 630                 635                 640 


Asn Leu Leu Glu Pro Xaa Arg Val Ser Met Pro Xaa Glu Asn Ile Val 
                645                 650                 655     


Leu Glu Val Ala Val Leu Ser Xaa Glu Gly Gln Ile Gln Asp Phe Lys 
            660                 665                 670         


Phe Pro Leu Gly Ile Lys Gly Ala Gly Ser Ser Ile Gln Leu Ser Ala 
        675                 680                 685             


Asn Xaa Val Lys Gln Asn Ser Arg Asn Gly Leu Ala Lys Leu Val Phe 
    690                 695                 700                 


Ile Ile Tyr Arg Ser Leu Gly Gln Phe Leu Ser Xaa Glu Asn Ala Xaa 
705                 710                 715                 720 


Ile Lys Leu Gly Ala Asp Phe Ile Gly Arg Asn Ser Xaa Ile Ala Val 
                725                 730                 735     


Asn Ser His Val Ile Ser Val Ser Ile Asn Lys Glu Ser Ser Arg Val 
            740                 745                 750         


Tyr Leu Xaa Asp Pro Val Leu Phe Xaa Leu Pro His Ile Asp Pro Asp 
        755                 760                 765             


Asn Tyr Phe Asn Ala Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg Xaa 
    770                 775                 780                 


Met Met Gly Tyr Trp Ser Xaa Gln Gly Cys Lys Leu Val Asp Xaa Asn 
785                 790                 795                 800 


Lys Xaa Arg Xaa Xaa Cys Ala Cys Ser His Leu Xaa Asn Phe Ala Ile 
                805                 810                 815     


Leu Met Ala His Arg Glu Ile Ala Tyr Lys Asp Gly Val His Glu Leu 
            820                 825                 830         


Leu Leu Xaa Val Ile Xaa Trp Val Gly Ile Val Ile Ser Leu Val Cys 
        835                 840                 845             


Leu Ala Ile Cys Ile Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser 
    850                 855                 860                 


Asp Arg Asn Xaa Ile His Lys Asn Leu Cys Ile Asn Leu Phe Ile Ala 
865                 870                 875                 880 


Glu Phe Ile Phe Leu Ile Gly Ile Asp Lys Xaa Lys Tyr Ala Ile Ala 
                885                 890                 895     


Cys Pro Ile Phe Ala Gly Leu Leu His Phe Phe Phe Leu Ala Ala Phe 
            900                 905                 910         


Ala Trp Met Cys Leu Glu Gly Val Gln Leu Tyr Leu Met Leu Val Glu 
        915                 920                 925             


Val Phe Glu Ser Glu Tyr Ser Arg Lys Lys Tyr Tyr Tyr Val Ala Gly 
    930                 935                 940                 


Tyr Leu Phe Pro Ala Xaa Val Val Gly Val Ser Ala Ala Ile Asp Tyr 
945                 950                 955                 960 


Lys Ser Tyr Gly Xaa Glu Lys Ala Cys Trp Leu His Val Asp Asn Tyr 
                965                 970                 975     


Phe Ile Trp Ser Phe Ile Gly Pro Val Xaa Phe Ile Ile Leu Leu Asn 
            980                 985                 990         


Ile Ile Phe Leu Val Ile Xaa Leu  Cys Lys Met Val Lys  His Ser Asn 
        995                 1000                 1005             


Xaa Leu  Lys Pro Asp Ser Ser  Arg Leu Glu Asn Ile  Lys Ser Trp 
    1010                 1015                 1020             


Val Leu  Gly Ala Phe Ala Leu  Leu Cys Leu Leu Gly  Leu Xaa Trp 
    1025                 1030                 1035             


Ser Phe  Gly Leu Leu Phe Ile  Asn Glu Glu Xaa Ile  Val Met Ala 
    1040                 1045                 1050             


Tyr Leu  Phe Xaa Ile Phe Asn  Ala Phe Gln Gly Val  Phe Ile Phe 
    1055                 1060                 1065             


Ile Phe  His Cys Ala Leu Gln  Lys Lys Val Arg Lys  Glu Tyr Gly 
    1070                 1075                 1080             


Lys Cys  Phe Arg His Ser Tyr  Cys Cys Gly Gly Leu  Pro Xaa Glu 
    1085                 1090                 1095             


Ser Pro  His Ser Ser Val Lys  Ala Ser Xaa Xaa Arg  Xaa Ser Ala 
    1100                 1105                 1110             


Arg Tyr  Ser Ser Gly Xaa Gln  Asp Ile His 
    1115                 1120             


<210> 1762
<211> 1177
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1108)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<400> 1762
Met Val Ser Ser Gly Cys Arg Met Arg Ser Leu Trp Phe Ile Ile Val 
1               5                   10                  15      


Ile Ser Phe Leu Pro Asn Xaa Glu Gly Phe Ser Arg Ala Ala Leu Pro 
            20                  25                  30          


Phe Gly Leu Val Arg Arg Glu Leu Ser Cys Glu Gly Tyr Ser Ile Asp 
        35                  40                  45              


Leu Arg Cys Pro Gly Ser Asp Val Ile Met Ile Glu Ser Ala Asn Tyr 
    50                  55                  60                  


Gly Arg Xaa Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu 
65                  70                  75                  80  


Asn Xaa Asp Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Xaa Gln Arg 
                85                  90                  95      


Cys Asn Asn Arg Xaa Gln Cys Ile Val Val Xaa Gly Ser Asp Val Phe 
            100                 105                 110         


Pro Asp Pro Cys Pro Gly Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu 
        115                 120                 125             


Cys Val Pro Tyr Ile Phe Val Cys Pro Gly Xaa Leu Lys Ala Ile Val 
    130                 135                 140                 


Asp Ser Pro Cys Ile Tyr Glu Ala Glu Gln Lys Ala Gly Ala Trp Cys 
145                 150                 155                 160 


Lys Asp Pro Leu Gln Ala Ala Asp Lys Ile Tyr Phe Met Pro Trp Xaa 
                165                 170                 175     


Pro Tyr Arg Xaa Asp Xaa Leu Ile Glu Tyr Ala Ser Leu Glu Asp Phe 
            180                 185                 190         


Gln Asn Ser Arg Gln Xaa Xaa Xaa Tyr Lys Leu Pro Asn Arg Val Asp 
        195                 200                 205             


Gly Xaa Gly Phe Val Val Tyr Asp Gly Ala Val Phe Phe Asn Lys Glu 
    210                 215                 220                 


Arg Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg Ile Lys Ser 
225                 230                 235                 240 


Gly Glu Ala Ile Ile Asn Tyr Ala Asn Tyr His Asp Xaa Ser Pro Tyr 
                245                 250                 255     


Arg Trp Gly Gly Lys Xaa Asp Ile Asp Leu Ala Val Asp Glu Asn Gly 
            260                 265                 270         


Leu Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Met Ile Val Ile 
        275                 280                 285             


Ser Gln Leu Asn Pro Tyr Xaa Leu Arg Phe Glu Ala Xaa Trp Glu Xaa 
    290                 295                 300                 


Val Tyr Asp Lys Arg Ala Ala Ser Asn Ala Phe Met Ile Cys Gly Val 
305                 310                 315                 320 


Leu Tyr Val Val Arg Ser Val Tyr Gln Asp Asn Glu Ser Glu Xaa Gly 
                325                 330                 335     


Lys Asn Ser Ile Asp Tyr Ile Tyr Asn Xaa Arg Leu Asn Arg Gly Glu 
            340                 345                 350         


Tyr Val Asp Val Pro Phe Pro Asn Gln Tyr Gln Tyr Ile Ala Ala Val 
        355                 360                 365             


Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp Asn Asn Asn Phe 
    370                 375                 380                 


Ile Leu Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp Pro Ala Gln Val 
385                 390                 395                 400 


Pro Xaa Xaa Ala Val Xaa Ile Xaa Ser Ser Ala Glu Leu Phe Lys Xaa 
                405                 410                 415     


Ile Ile Ser Xaa Xaa Ser Xaa Xaa Ser Gln Lys Gly Pro Met Ser Xaa 
            420                 425                 430         


Xaa Val Ala Gly Ser Gln Glu Gly Ser Lys Gly Xaa Lys Pro Pro Pro 
        435                 440                 445             


Ala Val Ser Xaa Xaa Lys Ile Pro Pro Ile Xaa Asn Ile Phe Pro Leu 
    450                 455                 460                 


Pro Glu Arg Phe Cys Glu Ala Leu Asp Ser Lys Gly Ile Lys Trp Pro 
465                 470                 475                 480 


Gln Xaa Gln Arg Gly Met Met Val Glu Arg Pro Cys Pro Lys Gly Xaa 
                485                 490                 495     


Arg Gly Xaa Ala Ser Tyr Leu Cys Met Ile Ser Xaa Gly Xaa Trp Asn 
            500                 505                 510         


Pro Lys Gly Pro Asp Leu Ser Asn Cys Xaa Ser His Trp Val Asn Gln 
        515                 520                 525             


Leu Ala Gln Lys Ile Arg Ser Gly Glu Asn Ala Ala Ser Leu Ala Asn 
    530                 535                 540                 


Glu Leu Ala Lys His Xaa Lys Gly Pro Val Phe Ala Gly Asp Val Ser 
545                 550                 555                 560 


Ser Ser Val Arg Leu Met Glu Gln Leu Val Asp Ile Leu Asp Ala Gln 
                565                 570                 575     


Leu Gln Glu Leu Lys Pro Ser Glu Lys Asp Ser Ala Gly Arg Ser Tyr 
            580                 585                 590         


Asn Lys Ala Ile Val Asp Xaa Val Asp Asn Leu Leu Arg Pro Glu Ala 
        595                 600                 605             


Leu Glu Ser Trp Lys His Met Asn Ser Ser Glu Gln Ala His Xaa Ala 
    610                 615                 620                 


Xaa Met Leu Leu Asp Xaa Leu Glu Glu Gly Ala Phe Val Leu Ala Asp 
625                 630                 635                 640 


Asn Leu Leu Glu Pro Xaa Arg Val Ser Met Pro Xaa Glu Asn Ile Val 
                645                 650                 655     


Leu Glu Val Ala Val Leu Ser Xaa Glu Gly Gln Ile Gln Asp Phe Lys 
            660                 665                 670         


Phe Pro Leu Gly Ile Lys Gly Ala Gly Ser Ser Ile Gln Leu Ser Ala 
        675                 680                 685             


Asn Xaa Val Lys Gln Asn Ser Arg Asn Gly Leu Ala Lys Leu Val Phe 
    690                 695                 700                 


Ile Ile Tyr Arg Ser Leu Gly Gln Phe Leu Ser Xaa Glu Asn Ala Xaa 
705                 710                 715                 720 


Ile Lys Leu Gly Ala Asp Phe Ile Gly Arg Asn Ser Xaa Ile Ala Val 
                725                 730                 735     


Asn Ser His Val Ile Ser Val Ser Ile Asn Lys Glu Ser Ser Arg Val 
            740                 745                 750         


Tyr Leu Xaa Asp Pro Val Leu Phe Xaa Leu Pro His Ile Asp Pro Asp 
        755                 760                 765             


Asn Tyr Phe Asn Ala Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg Xaa 
    770                 775                 780                 


Met Met Gly Tyr Trp Ser Xaa Gln Gly Cys Lys Leu Val Asp Xaa Asn 
785                 790                 795                 800 


Lys Xaa Arg Xaa Xaa Cys Ala Cys Ser His Leu Xaa Asn Phe Ala Ile 
                805                 810                 815     


Leu Met Ala His Arg Glu Ile Ala Tyr Lys Asp Gly Val His Glu Leu 
            820                 825                 830         


Leu Leu Xaa Val Ile Xaa Trp Val Gly Ile Val Ile Ser Leu Val Cys 
        835                 840                 845             


Leu Ala Ile Cys Ile Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser 
    850                 855                 860                 


Asp Arg Asn Xaa Ile His Lys Asn Leu Cys Ile Asn Leu Phe Ile Ala 
865                 870                 875                 880 


Glu Phe Ile Phe Leu Ile Gly Ile Asp Lys Xaa Lys Tyr Ala Ile Ala 
                885                 890                 895     


Cys Pro Ile Phe Ala Gly Leu Leu His Phe Phe Phe Leu Ala Ala Phe 
            900                 905                 910         


Ala Trp Met Cys Leu Glu Gly Val Gln Leu Tyr Leu Met Leu Val Glu 
        915                 920                 925             


Val Phe Glu Ser Glu Tyr Ser Arg Lys Lys Tyr Tyr Tyr Val Ala Gly 
    930                 935                 940                 


Tyr Leu Phe Pro Ala Xaa Val Val Gly Val Ser Ala Ala Ile Asp Tyr 
945                 950                 955                 960 


Lys Ser Tyr Gly Xaa Glu Lys Ala Cys Trp Leu His Val Asp Asn Tyr 
                965                 970                 975     


Phe Ile Trp Ser Phe Ile Gly Pro Val Xaa Phe Ile Ile Leu Leu Asn 
            980                 985                 990         


Ile Ile Phe Leu Val Ile Xaa Leu  Cys Lys Met Val Lys  His Ser Asn 
        995                 1000                 1005             


Xaa Leu  Lys Pro Asp Ser Ser  Arg Leu Glu Asn Ile  Lys Ser Trp 
    1010                 1015                 1020             


Val Leu  Gly Ala Phe Ala Leu  Leu Cys Leu Leu Gly  Leu Xaa Trp 
    1025                 1030                 1035             


Ser Phe  Gly Leu Leu Phe Ile  Asn Glu Glu Xaa Ile  Val Met Ala 
    1040                 1045                 1050             


Tyr Leu  Phe Xaa Ile Phe Asn  Ala Phe Gln Gly Val  Phe Ile Phe 
    1055                 1060                 1065             


Ile Phe  His Cys Ala Leu Gln  Lys Lys Val Arg Lys  Glu Tyr Gly 
    1070                 1075                 1080             


Lys Cys  Phe Arg His Ser Tyr  Cys Cys Gly Gly Leu  Pro Xaa Glu 
    1085                 1090                 1095             


Ser Pro  His Ser Ser Val Lys  Ala Ser Xaa Xaa Arg  Xaa Ser Ala 
    1100                 1105                 1110             


Arg Tyr  Ser Ser Gly Xaa Gln  Ser Arg Ile Arg Arg  Met Trp Asn 
    1115                 1120                 1125             


Asp Xaa  Val Arg Lys Gln Ser  Glu Ser Ser Phe Ile  Ser Gly Asp 
    1130                 1135                 1140             


Ile Asn  Ser Xaa Ser Xaa Leu  Asn Gln Gly Leu Xaa  Ser His Gly 
    1145                 1150                 1155             


Leu Arg  Ala His Leu Gln Asp  Leu Tyr His Leu Glu  Leu Leu Leu 
    1160                 1165                 1170             


Gly Gln  Ile Ala 
    1175         


<210> 1763
<211> 1403
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1108)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1222)..(1222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1276)..(1276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1300)..(1300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1317)..(1317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<400> 1763
Met Val Ser Ser Gly Cys Arg Met Arg Ser Leu Trp Phe Ile Ile Val 
1               5                   10                  15      


Ile Ser Phe Leu Pro Asn Xaa Glu Gly Phe Ser Arg Ala Ala Leu Pro 
            20                  25                  30          


Phe Gly Leu Val Arg Arg Glu Leu Ser Cys Glu Gly Tyr Ser Ile Asp 
        35                  40                  45              


Leu Arg Cys Pro Gly Ser Asp Val Ile Met Ile Glu Ser Ala Asn Tyr 
    50                  55                  60                  


Gly Arg Xaa Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu 
65                  70                  75                  80  


Asn Xaa Asp Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Xaa Gln Arg 
                85                  90                  95      


Cys Asn Asn Arg Xaa Gln Cys Ile Val Val Xaa Gly Ser Asp Val Phe 
            100                 105                 110         


Pro Asp Pro Cys Pro Gly Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu 
        115                 120                 125             


Cys Val Pro Tyr Ile Phe Val Cys Pro Gly Xaa Leu Lys Ala Ile Val 
    130                 135                 140                 


Asp Ser Pro Cys Ile Tyr Glu Ala Glu Gln Lys Ala Gly Ala Trp Cys 
145                 150                 155                 160 


Lys Asp Pro Leu Gln Ala Ala Asp Lys Ile Tyr Phe Met Pro Trp Xaa 
                165                 170                 175     


Pro Tyr Arg Xaa Asp Xaa Leu Ile Glu Tyr Ala Ser Leu Glu Asp Phe 
            180                 185                 190         


Gln Asn Ser Arg Gln Xaa Xaa Xaa Tyr Lys Leu Pro Asn Arg Val Asp 
        195                 200                 205             


Gly Xaa Gly Phe Val Val Tyr Asp Gly Ala Val Phe Phe Asn Lys Glu 
    210                 215                 220                 


Arg Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg Ile Lys Ser 
225                 230                 235                 240 


Gly Glu Ala Ile Ile Asn Tyr Ala Asn Tyr His Asp Xaa Ser Pro Tyr 
                245                 250                 255     


Arg Trp Gly Gly Lys Xaa Asp Ile Asp Leu Ala Val Asp Glu Asn Gly 
            260                 265                 270         


Leu Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Met Ile Val Ile 
        275                 280                 285             


Ser Gln Leu Asn Pro Tyr Xaa Leu Arg Phe Glu Ala Xaa Trp Glu Xaa 
    290                 295                 300                 


Val Tyr Asp Lys Arg Ala Ala Ser Asn Ala Phe Met Ile Cys Gly Val 
305                 310                 315                 320 


Leu Tyr Val Val Arg Ser Val Tyr Gln Asp Asn Glu Ser Glu Xaa Gly 
                325                 330                 335     


Lys Asn Ser Ile Asp Tyr Ile Tyr Asn Xaa Arg Leu Asn Arg Gly Glu 
            340                 345                 350         


Tyr Val Asp Val Pro Phe Pro Asn Gln Tyr Gln Tyr Ile Ala Ala Val 
        355                 360                 365             


Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp Asn Asn Asn Phe 
    370                 375                 380                 


Ile Leu Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp Pro Ala Gln Val 
385                 390                 395                 400 


Pro Xaa Xaa Ala Val Xaa Ile Xaa Ser Ser Ala Glu Leu Phe Lys Xaa 
                405                 410                 415     


Ile Ile Ser Xaa Xaa Ser Xaa Xaa Ser Gln Lys Gly Pro Met Ser Xaa 
            420                 425                 430         


Xaa Val Ala Gly Ser Gln Glu Gly Ser Lys Gly Xaa Lys Pro Pro Pro 
        435                 440                 445             


Ala Val Ser Xaa Xaa Lys Ile Pro Pro Ile Xaa Asn Ile Phe Pro Leu 
    450                 455                 460                 


Pro Glu Arg Phe Cys Glu Ala Leu Asp Ser Lys Gly Ile Lys Trp Pro 
465                 470                 475                 480 


Gln Xaa Gln Arg Gly Met Met Val Glu Arg Pro Cys Pro Lys Gly Xaa 
                485                 490                 495     


Arg Gly Xaa Ala Ser Tyr Leu Cys Met Ile Ser Xaa Gly Xaa Trp Asn 
            500                 505                 510         


Pro Lys Gly Pro Asp Leu Ser Asn Cys Xaa Ser His Trp Val Asn Gln 
        515                 520                 525             


Leu Ala Gln Lys Ile Arg Ser Gly Glu Asn Ala Ala Ser Leu Ala Asn 
    530                 535                 540                 


Glu Leu Ala Lys His Xaa Lys Gly Pro Val Phe Ala Gly Asp Val Ser 
545                 550                 555                 560 


Ser Ser Val Arg Leu Met Glu Gln Leu Val Asp Ile Leu Asp Ala Gln 
                565                 570                 575     


Leu Gln Glu Leu Lys Pro Ser Glu Lys Asp Ser Ala Gly Arg Ser Tyr 
            580                 585                 590         


Asn Lys Ala Ile Val Asp Xaa Val Asp Asn Leu Leu Arg Pro Glu Ala 
        595                 600                 605             


Leu Glu Ser Trp Lys His Met Asn Ser Ser Glu Gln Ala His Xaa Ala 
    610                 615                 620                 


Xaa Met Leu Leu Asp Xaa Leu Glu Glu Gly Ala Phe Val Leu Ala Asp 
625                 630                 635                 640 


Asn Leu Leu Glu Pro Xaa Arg Val Ser Met Pro Xaa Glu Asn Ile Val 
                645                 650                 655     


Leu Glu Val Ala Val Leu Ser Xaa Glu Gly Gln Ile Gln Asp Phe Lys 
            660                 665                 670         


Phe Pro Leu Gly Ile Lys Gly Ala Gly Ser Ser Ile Gln Leu Ser Ala 
        675                 680                 685             


Asn Xaa Val Lys Gln Asn Ser Arg Asn Gly Leu Ala Lys Leu Val Phe 
    690                 695                 700                 


Ile Ile Tyr Arg Ser Leu Gly Gln Phe Leu Ser Xaa Glu Asn Ala Xaa 
705                 710                 715                 720 


Ile Lys Leu Gly Ala Asp Phe Ile Gly Arg Asn Ser Xaa Ile Ala Val 
                725                 730                 735     


Asn Ser His Val Ile Ser Val Ser Ile Asn Lys Glu Ser Ser Arg Val 
            740                 745                 750         


Tyr Leu Xaa Asp Pro Val Leu Phe Xaa Leu Pro His Ile Asp Pro Asp 
        755                 760                 765             


Asn Tyr Phe Asn Ala Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg Xaa 
    770                 775                 780                 


Met Met Gly Tyr Trp Ser Xaa Gln Gly Cys Lys Leu Val Asp Xaa Asn 
785                 790                 795                 800 


Lys Xaa Arg Xaa Xaa Cys Ala Cys Ser His Leu Xaa Asn Phe Ala Ile 
                805                 810                 815     


Leu Met Ala His Arg Glu Ile Ala Tyr Lys Asp Gly Val His Glu Leu 
            820                 825                 830         


Leu Leu Xaa Val Ile Xaa Trp Val Gly Ile Val Ile Ser Leu Val Cys 
        835                 840                 845             


Leu Ala Ile Cys Ile Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser 
    850                 855                 860                 


Asp Arg Asn Xaa Ile His Lys Asn Leu Cys Ile Asn Leu Phe Ile Ala 
865                 870                 875                 880 


Glu Phe Ile Phe Leu Ile Gly Ile Asp Lys Xaa Lys Tyr Ala Ile Ala 
                885                 890                 895     


Cys Pro Ile Phe Ala Gly Leu Leu His Phe Phe Phe Leu Ala Ala Phe 
            900                 905                 910         


Ala Trp Met Cys Leu Glu Gly Val Gln Leu Tyr Leu Met Leu Val Glu 
        915                 920                 925             


Val Phe Glu Ser Glu Tyr Ser Arg Lys Lys Tyr Tyr Tyr Val Ala Gly 
    930                 935                 940                 


Tyr Leu Phe Pro Ala Xaa Val Val Gly Val Ser Ala Ala Ile Asp Tyr 
945                 950                 955                 960 


Lys Ser Tyr Gly Xaa Glu Lys Ala Cys Trp Leu His Val Asp Asn Tyr 
                965                 970                 975     


Phe Ile Trp Ser Phe Ile Gly Pro Val Xaa Phe Ile Ile Leu Leu Asn 
            980                 985                 990         


Ile Ile Phe Leu Val Ile Xaa Leu  Cys Lys Met Val Lys  His Ser Asn 
        995                 1000                 1005             


Xaa Leu  Lys Pro Asp Ser Ser  Arg Leu Glu Asn Ile  Lys Ser Trp 
    1010                 1015                 1020             


Val Leu  Gly Ala Phe Ala Leu  Leu Cys Leu Leu Gly  Leu Xaa Trp 
    1025                 1030                 1035             


Ser Phe  Gly Leu Leu Phe Ile  Asn Glu Glu Xaa Ile  Val Met Ala 
    1040                 1045                 1050             


Tyr Leu  Phe Xaa Ile Phe Asn  Ala Phe Gln Gly Val  Phe Ile Phe 
    1055                 1060                 1065             


Ile Phe  His Cys Ala Leu Gln  Lys Lys Val Arg Lys  Glu Tyr Gly 
    1070                 1075                 1080             


Lys Cys  Phe Arg His Ser Tyr  Cys Cys Gly Gly Leu  Pro Xaa Glu 
    1085                 1090                 1095             


Ser Pro  His Ser Ser Val Lys  Ala Ser Xaa Xaa Arg  Xaa Ser Ala 
    1100                 1105                 1110             


Arg Tyr  Ser Ser Gly Xaa Gln  Ser Arg Ile Arg Arg  Met Trp Asn 
    1115                 1120                 1125             


Asp Xaa  Val Arg Lys Gln Ser  Glu Ser Ser Phe Ile  Ser Gly Asp 
    1130                 1135                 1140             


Ile Asn  Ser Xaa Ser Xaa Leu  Asn Gln Gly His Ser  Leu Asn Asn 
    1145                 1150                 1155             


Ala Arg  Asp Xaa Ser Ala Met  Asp Xaa Leu Pro Leu  Asn Gly Asn 
    1160                 1165                 1170             


Phe Asn  Asn Ser Tyr Ser Leu  His Lys Gly Asp Tyr  Asn Asp Ser 
    1175                 1180                 1185             


Val Gln  Val Val Asp Cys Gly  Leu Ser Leu Asn Asp  Xaa Ala Phe 
    1190                 1195                 1200             


Glu Lys  Met Ile Ile Ser Glu  Leu Val His Asn Asn  Leu Arg Gly 
    1205                 1210                 1215             


Ser Ser  Lys Xaa His Asn Leu  Glu Leu Xaa Leu Pro  Val Lys Pro 
    1220                 1225                 1230             


Val Ile  Gly Gly Ser Ser Ser  Glu Asp Asp Ala Ile  Val Ala Asp 
    1235                 1240                 1245             


Ala Ser  Ser Leu Met His Ser  Asp Asn Pro Gly Leu  Glu Leu His 
    1250                 1255                 1260             


His Lys  Glu Leu Glu Ala Pro  Leu Ile Pro Gln Arg  Xaa His Ser 
    1265                 1270                 1275             


Leu Leu  Tyr Gln Pro Gln Lys  Lys Val Lys Ser Glu  Gly Xaa Asp 
    1280                 1285                 1290             


Ser Tyr  Val Ser Gln Leu Xaa  Ala Glu Ala Glu Asp  His Leu Gln 
    1295                 1300                 1305             


Ser Pro  Asn Arg Asp Ser Leu  Tyr Xaa Ser Met Pro  Asn Leu Arg 
    1310                 1315                 1320             


Asp Ser  Pro Tyr Pro Glu Ser  Ser Pro Asp Met Glu  Glu Asp Leu 
    1325                 1330                 1335             


Ser Pro  Ser Arg Arg Ser Glu  Asn Glu Asp Ile Tyr  Tyr Lys Ser 
    1340                 1345                 1350             


Met Pro  Asn Leu Gly Ala Gly  His Gln Leu Gln Met  Cys Tyr Gln 
    1355                 1360                 1365             


Ile Ser  Arg Gly Asn Ser Asp  Gly Tyr Ile Ile Pro  Ile Asn Lys 
    1370                 1375                 1380             


Glu Gly  Cys Ile Pro Glu Gly  Asp Val Arg Glu Gly  Gln Met Gln 
    1385                 1390                 1395             


Leu Val  Xaa Ser Leu 
    1400             


<210> 1764
<211> 1416
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1214)..(1214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1235)..(1235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1313)..(1313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1330)..(1330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<400> 1764
Met Val Ser Ser Gly Cys Arg Met Arg Ser Leu Trp Phe Ile Ile Val 
1               5                   10                  15      


Ile Ser Phe Leu Pro Asn Xaa Glu Gly Phe Ser Arg Ala Ala Leu Pro 
            20                  25                  30          


Phe Gly Leu Val Arg Arg Glu Leu Ser Cys Glu Gly Tyr Ser Ile Asp 
        35                  40                  45              


Leu Arg Cys Pro Gly Ser Asp Val Ile Met Ile Glu Ser Ala Asn Tyr 
    50                  55                  60                  


Gly Arg Xaa Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu 
65                  70                  75                  80  


Asn Xaa Asp Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Xaa Gln Arg 
                85                  90                  95      


Cys Asn Asn Arg Xaa Gln Cys Ile Val Val Xaa Gly Ser Asp Val Phe 
            100                 105                 110         


Pro Asp Pro Cys Pro Gly Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu 
        115                 120                 125             


Cys Val Pro Tyr Ile Phe Val Cys Pro Gly Xaa Leu Lys Ala Ile Val 
    130                 135                 140                 


Asp Ser Pro Cys Ile Tyr Glu Ala Glu Gln Lys Ala Gly Ala Trp Cys 
145                 150                 155                 160 


Lys Asp Pro Leu Gln Ala Ala Asp Lys Ile Tyr Phe Met Pro Trp Xaa 
                165                 170                 175     


Pro Tyr Arg Xaa Asp Xaa Leu Ile Glu Tyr Ala Ser Leu Glu Asp Phe 
            180                 185                 190         


Gln Asn Ser Arg Gln Xaa Xaa Xaa Tyr Lys Leu Pro Asn Arg Val Asp 
        195                 200                 205             


Gly Xaa Gly Phe Val Val Tyr Asp Gly Ala Val Phe Phe Asn Lys Glu 
    210                 215                 220                 


Arg Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg Ile Lys Ser 
225                 230                 235                 240 


Gly Glu Ala Ile Ile Asn Tyr Ala Asn Tyr His Asp Xaa Ser Pro Tyr 
                245                 250                 255     


Arg Trp Gly Gly Lys Xaa Asp Ile Asp Leu Ala Val Asp Glu Asn Gly 
            260                 265                 270         


Leu Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Met Ile Val Ile 
        275                 280                 285             


Ser Gln Leu Asn Pro Tyr Xaa Leu Arg Phe Glu Ala Xaa Trp Glu Xaa 
    290                 295                 300                 


Val Tyr Asp Lys Arg Ala Ala Ser Asn Ala Phe Met Ile Cys Gly Val 
305                 310                 315                 320 


Leu Tyr Val Val Arg Ser Val Tyr Gln Asp Asn Glu Ser Glu Xaa Gly 
                325                 330                 335     


Lys Asn Ser Ile Asp Tyr Ile Tyr Asn Xaa Arg Leu Asn Arg Gly Glu 
            340                 345                 350         


Tyr Val Asp Val Pro Phe Pro Asn Gln Tyr Gln Tyr Ile Ala Ala Val 
        355                 360                 365             


Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp Asn Asn Asn Phe 
    370                 375                 380                 


Ile Leu Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp Pro Ala Gln Val 
385                 390                 395                 400 


Pro Xaa Xaa Ala Val Xaa Ile Xaa Ser Ser Ala Glu Leu Phe Lys Xaa 
                405                 410                 415     


Ile Ile Ser Xaa Xaa Ser Xaa Xaa Ser Gln Lys Gly Pro Met Ser Xaa 
            420                 425                 430         


Xaa Val Ala Gly Ser Gln Glu Gly Ser Lys Gly Xaa Lys Pro Pro Pro 
        435                 440                 445             


Ala Val Ser Xaa Xaa Lys Ile Pro Pro Ile Xaa Asn Ile Phe Pro Leu 
    450                 455                 460                 


Pro Glu Arg Phe Cys Glu Ala Leu Asp Ser Lys Gly Ile Lys Trp Pro 
465                 470                 475                 480 


Gln Xaa Gln Arg Gly Met Met Val Glu Arg Pro Cys Pro Lys Gly Xaa 
                485                 490                 495     


Arg Gly Xaa Ala Ser Tyr Leu Cys Met Ile Ser Xaa Gly Xaa Trp Asn 
            500                 505                 510         


Pro Lys Gly Pro Asp Leu Ser Asn Cys Xaa Ser His Trp Val Asn Gln 
        515                 520                 525             


Leu Ala Gln Lys Ile Arg Ser Gly Glu Asn Ala Ala Ser Leu Ala Asn 
    530                 535                 540                 


Glu Leu Ala Lys His Xaa Lys Gly Pro Val Phe Ala Gly Asp Val Ser 
545                 550                 555                 560 


Ser Ser Val Arg Leu Met Glu Gln Leu Val Asp Ile Leu Asp Ala Gln 
                565                 570                 575     


Leu Gln Glu Leu Lys Pro Ser Glu Lys Asp Ser Ala Gly Arg Ser Tyr 
            580                 585                 590         


Asn Lys Leu Gln Lys Arg Glu Lys Xaa Cys Arg Ala Tyr Leu Lys Ala 
        595                 600                 605             


Ile Val Asp Xaa Val Asp Asn Leu Leu Arg Pro Glu Ala Leu Glu Ser 
    610                 615                 620                 


Trp Lys His Met Asn Ser Ser Glu Gln Ala His Xaa Ala Xaa Met Leu 
625                 630                 635                 640 


Leu Asp Xaa Leu Glu Glu Gly Ala Phe Val Leu Ala Asp Asn Leu Leu 
                645                 650                 655     


Glu Pro Xaa Arg Val Ser Met Pro Xaa Glu Asn Ile Val Leu Glu Val 
            660                 665                 670         


Ala Val Leu Ser Xaa Glu Gly Gln Ile Gln Asp Phe Lys Phe Pro Leu 
        675                 680                 685             


Gly Ile Lys Gly Ala Gly Ser Ser Ile Gln Leu Ser Ala Asn Xaa Val 
    690                 695                 700                 


Lys Gln Asn Ser Arg Asn Gly Leu Ala Lys Leu Val Phe Ile Ile Tyr 
705                 710                 715                 720 


Arg Ser Leu Gly Gln Phe Leu Ser Xaa Glu Asn Ala Xaa Ile Lys Leu 
                725                 730                 735     


Gly Ala Asp Phe Ile Gly Arg Asn Ser Xaa Ile Ala Val Asn Ser His 
            740                 745                 750         


Val Ile Ser Val Ser Ile Asn Lys Glu Ser Ser Arg Val Tyr Leu Xaa 
        755                 760                 765             


Asp Pro Val Leu Phe Xaa Leu Pro His Ile Asp Pro Asp Asn Tyr Phe 
    770                 775                 780                 


Asn Ala Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg Xaa Met Met Gly 
785                 790                 795                 800 


Tyr Trp Ser Xaa Gln Gly Cys Lys Leu Val Asp Xaa Asn Lys Xaa Arg 
                805                 810                 815     


Xaa Xaa Cys Ala Cys Ser His Leu Xaa Asn Phe Ala Ile Leu Met Ala 
            820                 825                 830         


His Arg Glu Ile Ala Tyr Lys Asp Gly Val His Glu Leu Leu Leu Xaa 
        835                 840                 845             


Val Ile Xaa Trp Val Gly Ile Val Ile Ser Leu Val Cys Leu Ala Ile 
    850                 855                 860                 


Cys Ile Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn 
865                 870                 875                 880 


Xaa Ile His Lys Asn Leu Cys Ile Asn Leu Phe Ile Ala Glu Phe Ile 
                885                 890                 895     


Phe Leu Ile Gly Ile Asp Lys Xaa Lys Tyr Ala Ile Ala Cys Pro Ile 
            900                 905                 910         


Phe Ala Gly Leu Leu His Phe Phe Phe Leu Ala Ala Phe Ala Trp Met 
        915                 920                 925             


Cys Leu Glu Gly Val Gln Leu Tyr Leu Met Leu Val Glu Val Phe Glu 
    930                 935                 940                 


Ser Glu Tyr Ser Arg Lys Lys Tyr Tyr Tyr Val Ala Gly Tyr Leu Phe 
945                 950                 955                 960 


Pro Ala Xaa Val Val Gly Val Ser Ala Ala Ile Asp Tyr Lys Ser Tyr 
                965                 970                 975     


Gly Xaa Glu Lys Ala Cys Trp Leu His Val Asp Asn Tyr Phe Ile Trp 
            980                 985                 990         


Ser Phe Ile Gly Pro Val Xaa Phe  Ile Ile Leu Leu Asn  Ile Ile Phe 
        995                 1000                 1005             


Leu Val  Ile Xaa Leu Cys Lys  Met Val Lys His Ser  Asn Xaa Leu 
    1010                 1015                 1020             


Lys Pro  Asp Ser Ser Arg Leu  Glu Asn Ile Lys Ser  Trp Val Leu 
    1025                 1030                 1035             


Gly Ala  Phe Ala Leu Leu Cys  Leu Leu Gly Leu Xaa  Trp Ser Phe 
    1040                 1045                 1050             


Gly Leu  Leu Phe Ile Asn Glu  Glu Xaa Ile Val Met  Ala Tyr Leu 
    1055                 1060                 1065             


Phe Xaa  Ile Phe Asn Ala Phe  Gln Gly Val Phe Ile  Phe Ile Phe 
    1070                 1075                 1080             


His Cys  Ala Leu Gln Lys Lys  Val Arg Lys Glu Tyr  Gly Lys Cys 
    1085                 1090                 1095             


Phe Arg  His Ser Tyr Cys Cys  Gly Gly Leu Pro Xaa  Glu Ser Pro 
    1100                 1105                 1110             


His Ser  Ser Val Lys Ala Ser  Xaa Xaa Arg Xaa Ser  Ala Arg Tyr 
    1115                 1120                 1125             


Ser Ser  Gly Xaa Gln Ser Arg  Ile Arg Arg Met Trp  Asn Asp Xaa 
    1130                 1135                 1140             


Val Arg  Lys Gln Ser Glu Ser  Ser Phe Ile Ser Gly  Asp Ile Asn 
    1145                 1150                 1155             


Ser Xaa  Ser Xaa Leu Asn Gln  Gly His Ser Leu Asn  Asn Ala Arg 
    1160                 1165                 1170             


Asp Xaa  Ser Ala Met Asp Xaa  Leu Pro Leu Asn Gly  Asn Phe Asn 
    1175                 1180                 1185             


Asn Ser  Tyr Ser Leu His Lys  Gly Asp Tyr Asn Asp  Ser Val Gln 
    1190                 1195                 1200             


Val Val  Asp Cys Gly Leu Ser  Leu Asn Asp Xaa Ala  Phe Glu Lys 
    1205                 1210                 1215             


Met Ile  Ile Ser Glu Leu Val  His Asn Asn Leu Arg  Gly Ser Ser 
    1220                 1225                 1230             


Lys Xaa  His Asn Leu Glu Leu  Xaa Leu Pro Val Lys  Pro Val Ile 
    1235                 1240                 1245             


Gly Gly  Ser Ser Ser Glu Asp  Asp Ala Ile Val Ala  Asp Ala Ser 
    1250                 1255                 1260             


Ser Leu  Met His Ser Asp Asn  Pro Gly Leu Glu Leu  His His Lys 
    1265                 1270                 1275             


Glu Leu  Glu Ala Pro Leu Ile  Pro Gln Arg Xaa His  Ser Leu Leu 
    1280                 1285                 1290             


Tyr Gln  Pro Gln Lys Lys Val  Lys Ser Glu Gly Xaa  Asp Ser Tyr 
    1295                 1300                 1305             


Val Ser  Gln Leu Xaa Ala Glu  Ala Glu Asp His Leu  Gln Ser Pro 
    1310                 1315                 1320             


Asn Arg  Asp Ser Leu Tyr Xaa  Ser Met Pro Asn Leu  Arg Asp Ser 
    1325                 1330                 1335             


Pro Tyr  Pro Glu Ser Ser Pro  Asp Met Glu Glu Asp  Leu Ser Pro 
    1340                 1345                 1350             


Ser Arg  Arg Ser Glu Asn Glu  Asp Ile Tyr Tyr Lys  Ser Met Pro 
    1355                 1360                 1365             


Asn Leu  Gly Ala Gly His Gln  Leu Gln Met Cys Tyr  Gln Ile Ser 
    1370                 1375                 1380             


Arg Gly  Asn Ser Asp Gly Tyr  Ile Ile Pro Ile Asn  Lys Glu Gly 
    1385                 1390                 1395             


Cys Ile  Pro Glu Gly Asp Val  Arg Glu Gly Gln Met  Gln Leu Val 
    1400                 1405                 1410             


Xaa Ser  Leu 
    1415     


<210> 1765
<211> 1431
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1190)..(1190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1195)..(1195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1304)..(1304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1320)..(1320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1328)..(1328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1429)..(1429)
<223> Selenocysteine

<400> 1765
Met Val Ser Ser Gly Cys Arg Met Arg Ser Leu Trp Phe Ile Ile Val 
1               5                   10                  15      


Ile Ser Phe Leu Pro Asn Xaa Glu Gly Phe Ser Arg Ala Ala Leu Pro 
            20                  25                  30          


Phe Gly Leu Val Arg Arg Glu Leu Ser Cys Glu Gly Tyr Ser Ile Asp 
        35                  40                  45              


Leu Arg Cys Pro Gly Ser Asp Val Ile Met Ile Glu Ser Ala Asn Tyr 
    50                  55                  60                  


Gly Arg Xaa Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu 
65                  70                  75                  80  


Asn Xaa Asp Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Xaa Gln Arg 
                85                  90                  95      


Cys Asn Asn Arg Xaa Gln Cys Ile Val Val Xaa Gly Ser Asp Val Phe 
            100                 105                 110         


Pro Asp Pro Cys Pro Gly Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu 
        115                 120                 125             


Cys Val Pro Tyr Ile Phe Val Cys Pro Gly Xaa Leu Lys Ala Ile Val 
    130                 135                 140                 


Asp Ser Pro Cys Ile Tyr Glu Ala Glu Gln Lys Ala Gly Ala Trp Cys 
145                 150                 155                 160 


Lys Asp Pro Leu Gln Ala Ala Asp Lys Ile Tyr Phe Met Pro Trp Xaa 
                165                 170                 175     


Pro Tyr Arg Xaa Asp Xaa Leu Ile Glu Tyr Ala Ser Leu Glu Asp Phe 
            180                 185                 190         


Gln Asn Ser Arg Gln Xaa Xaa Xaa Tyr Lys Leu Pro Asn Arg Val Asp 
        195                 200                 205             


Gly Xaa Gly Phe Val Val Tyr Asp Gly Ala Val Phe Phe Asn Lys Glu 
    210                 215                 220                 


Arg Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg Ile Lys Ser 
225                 230                 235                 240 


Gly Glu Ala Ile Ile Asn Tyr Ala Asn Tyr His Asp Xaa Ser Pro Tyr 
                245                 250                 255     


Arg Trp Gly Gly Lys Xaa Asp Ile Asp Leu Ala Val Asp Glu Asn Gly 
            260                 265                 270         


Leu Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Met Ile Val Ile 
        275                 280                 285             


Ser Gln Leu Asn Pro Tyr Xaa Leu Arg Phe Glu Ala Xaa Trp Glu Xaa 
    290                 295                 300                 


Val Tyr Asp Lys Arg Ala Ala Ser Asn Ala Phe Met Ile Cys Gly Val 
305                 310                 315                 320 


Leu Tyr Val Val Arg Ser Val Tyr Gln Asp Asn Glu Ser Glu Xaa Gly 
                325                 330                 335     


Lys Asn Ser Ile Asp Tyr Ile Tyr Asn Xaa Arg Leu Asn Arg Gly Glu 
            340                 345                 350         


Tyr Val Asp Val Pro Phe Pro Asn Gln Tyr Gln Tyr Ile Ala Ala Val 
        355                 360                 365             


Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp Asn Asn Asn Phe 
    370                 375                 380                 


Ile Leu Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp Pro Ala Gln Val 
385                 390                 395                 400 


Pro Xaa Xaa Ala Val Xaa Ile Xaa Ser Ser Ala Glu Leu Phe Lys Xaa 
                405                 410                 415     


Ile Ile Ser Xaa Xaa Ser Xaa Xaa Ser Gln Lys Gly Pro Met Ser Xaa 
            420                 425                 430         


Xaa Val Ala Gly Ser Gln Glu Gly Ser Lys Gly Xaa Lys Pro Pro Pro 
        435                 440                 445             


Ala Val Ser Xaa Xaa Lys Ile Pro Pro Ile Xaa Asn Ile Phe Pro Leu 
    450                 455                 460                 


Pro Glu Arg Phe Cys Glu Ala Leu Asp Ser Lys Gly Ile Lys Trp Pro 
465                 470                 475                 480 


Gln Xaa Gln Arg Gly Met Met Val Glu Arg Pro Cys Pro Lys Gly Xaa 
                485                 490                 495     


Arg Gly Xaa Ala Ser Tyr Leu Cys Met Ile Ser Xaa Gly Xaa Trp Asn 
            500                 505                 510         


Pro Lys Gly Pro Asp Leu Ser Asn Cys Xaa Ser His Trp Val Asn Gln 
        515                 520                 525             


Leu Ala Gln Lys Ile Arg Ser Gly Glu Asn Ala Ala Ser Leu Ala Asn 
    530                 535                 540                 


Glu Leu Ala Lys His Xaa Lys Gly Pro Val Phe Ala Gly Asp Val Ser 
545                 550                 555                 560 


Ser Ser Val Arg Leu Met Glu Gln Leu Val Asp Ile Leu Asp Ala Gln 
                565                 570                 575     


Leu Gln Glu Leu Lys Pro Ser Glu Lys Asp Ser Ala Gly Arg Ser Tyr 
            580                 585                 590         


Asn Lys Leu Gln Lys Arg Glu Lys Xaa Cys Arg Ala Tyr Leu Lys Ala 
        595                 600                 605             


Ile Val Asp Xaa Val Asp Asn Leu Leu Arg Pro Glu Ala Leu Glu Ser 
    610                 615                 620                 


Trp Lys His Met Asn Ser Ser Glu Gln Ala His Xaa Ala Xaa Met Leu 
625                 630                 635                 640 


Leu Asp Xaa Leu Glu Glu Gly Ala Phe Val Leu Ala Asp Asn Leu Leu 
                645                 650                 655     


Glu Pro Xaa Arg Val Ser Met Pro Xaa Glu Asn Ile Val Leu Glu Val 
            660                 665                 670         


Ala Val Leu Ser Xaa Glu Gly Gln Ile Gln Asp Phe Lys Phe Pro Leu 
        675                 680                 685             


Gly Ile Lys Gly Ala Gly Ser Ser Ile Gln Leu Ser Ala Asn Xaa Val 
    690                 695                 700                 


Lys Gln Asn Ser Arg Asn Gly Leu Ala Lys Leu Val Phe Ile Ile Tyr 
705                 710                 715                 720 


Arg Ser Leu Gly Gln Phe Leu Ser Xaa Glu Asn Ala Xaa Ile Lys Leu 
                725                 730                 735     


Gly Ala Asp Phe Ile Gly Arg Asn Ser Xaa Ile Ala Val Asn Ser His 
            740                 745                 750         


Val Ile Ser Val Ser Ile Asn Lys Glu Ser Ser Arg Val Tyr Leu Xaa 
        755                 760                 765             


Asp Pro Val Leu Phe Xaa Leu Pro His Ile Asp Pro Asp Asn Tyr Phe 
    770                 775                 780                 


Asn Ala Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg Xaa Met Met Gly 
785                 790                 795                 800 


Tyr Trp Ser Xaa Gln Gly Cys Lys Leu Val Asp Xaa Asn Lys Xaa Arg 
                805                 810                 815     


Xaa Xaa Cys Ala Cys Ser His Leu Xaa Asn Phe Ala Ile Leu Met Ala 
            820                 825                 830         


His Arg Glu Ile Ala Tyr Lys Asp Gly Val His Glu Leu Leu Leu Xaa 
        835                 840                 845             


Val Ile Xaa Trp Val Gly Ile Val Ile Ser Leu Val Cys Leu Ala Ile 
    850                 855                 860                 


Cys Ile Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn 
865                 870                 875                 880 


Xaa Ile His Lys Asn Leu Cys Ile Asn Leu Phe Ile Ala Glu Phe Ile 
                885                 890                 895     


Phe Leu Ile Gly Ile Asp Lys Xaa Lys Tyr Ala Ile Ala Cys Pro Ile 
            900                 905                 910         


Phe Ala Gly Leu Leu His Phe Phe Phe Leu Ala Ala Phe Ala Trp Met 
        915                 920                 925             


Cys Leu Glu Gly Val Gln Leu Tyr Leu Met Leu Val Glu Val Phe Glu 
    930                 935                 940                 


Ser Glu Tyr Ser Arg Lys Lys Tyr Tyr Tyr Val Ala Gly Tyr Leu Phe 
945                 950                 955                 960 


Pro Ala Xaa Val Val Gly Val Ser Ala Ala Ile Asp Tyr Lys Ser Tyr 
                965                 970                 975     


Gly Xaa Glu Lys Ala Cys Trp Leu His Val Asp Asn Tyr Phe Ile Trp 
            980                 985                 990         


Ser Phe Ile Gly Pro Val Xaa Phe  Ile Ile Leu Leu Asn  Ile Ile Phe 
        995                 1000                 1005             


Leu Val  Ile Xaa Leu Cys Lys  Met Val Lys His Ser  Asn Xaa Leu 
    1010                 1015                 1020             


Lys Pro  Asp Ser Ser Arg Leu  Glu Asn Ile Asn Asn  Tyr Arg Val 
    1025                 1030                 1035             


Cys Asp  Gly Tyr Tyr Asn Xaa  Asp Leu Pro Gly Ser  Trp Val Leu 
    1040                 1045                 1050             


Gly Ala  Phe Ala Leu Leu Cys  Leu Leu Gly Leu Xaa  Trp Ser Phe 
    1055                 1060                 1065             


Gly Leu  Leu Phe Ile Asn Glu  Glu Xaa Ile Val Met  Ala Tyr Leu 
    1070                 1075                 1080             


Phe Xaa  Ile Phe Asn Ala Phe  Gln Gly Val Phe Ile  Phe Ile Phe 
    1085                 1090                 1095             


His Cys  Ala Leu Gln Lys Lys  Val Arg Lys Glu Tyr  Gly Lys Cys 
    1100                 1105                 1110             


Phe Arg  His Ser Tyr Cys Cys  Gly Gly Leu Pro Xaa  Glu Ser Pro 
    1115                 1120                 1125             


His Ser  Ser Val Lys Ala Ser  Xaa Xaa Arg Xaa Ser  Ala Arg Tyr 
    1130                 1135                 1140             


Ser Ser  Gly Xaa Gln Ser Arg  Ile Arg Arg Met Trp  Asn Asp Xaa 
    1145                 1150                 1155             


Val Arg  Lys Gln Ser Glu Ser  Ser Phe Ile Ser Gly  Asp Ile Asn 
    1160                 1165                 1170             


Ser Xaa  Ser Xaa Leu Asn Gln  Gly His Ser Leu Asn  Asn Ala Arg 
    1175                 1180                 1185             


Asp Xaa  Ser Ala Met Asp Xaa  Leu Pro Leu Asn Gly  Asn Phe Asn 
    1190                 1195                 1200             


Asn Ser  Tyr Ser Leu His Lys  Gly Asp Tyr Asn Asp  Ser Val Gln 
    1205                 1210                 1215             


Val Val  Asp Cys Gly Leu Ser  Leu Asn Asp Xaa Ala  Phe Glu Lys 
    1220                 1225                 1230             


Met Ile  Ile Ser Glu Leu Val  His Asn Asn Leu Arg  Gly Ser Ser 
    1235                 1240                 1245             


Lys Xaa  His Asn Leu Glu Leu  Xaa Leu Pro Val Lys  Pro Val Ile 
    1250                 1255                 1260             


Gly Gly  Ser Ser Ser Glu Asp  Asp Ala Ile Val Ala  Asp Ala Ser 
    1265                 1270                 1275             


Ser Leu  Met His Ser Asp Asn  Pro Gly Leu Glu Leu  His His Lys 
    1280                 1285                 1290             


Glu Leu  Glu Ala Pro Leu Ile  Pro Gln Arg Xaa His  Ser Leu Leu 
    1295                 1300                 1305             


Tyr Gln  Pro Gln Lys Lys Val  Lys Ser Glu Gly Xaa  Asp Ser Tyr 
    1310                 1315                 1320             


Val Ser  Gln Leu Xaa Ala Glu  Ala Glu Asp His Leu  Gln Ser Pro 
    1325                 1330                 1335             


Asn Arg  Asp Ser Leu Tyr Xaa  Ser Met Pro Asn Leu  Arg Asp Ser 
    1340                 1345                 1350             


Pro Tyr  Pro Glu Ser Ser Pro  Asp Met Glu Glu Asp  Leu Ser Pro 
    1355                 1360                 1365             


Ser Arg  Arg Ser Glu Asn Glu  Asp Ile Tyr Tyr Lys  Ser Met Pro 
    1370                 1375                 1380             


Asn Leu  Gly Ala Gly His Gln  Leu Gln Met Cys Tyr  Gln Ile Ser 
    1385                 1390                 1395             


Arg Gly  Asn Ser Asp Gly Tyr  Ile Ile Pro Ile Asn  Lys Glu Gly 
    1400                 1405                 1410             


Cys Ile  Pro Glu Gly Asp Val  Arg Glu Gly Gln Met  Gln Leu Val 
    1415                 1420                 1425             


Xaa Ser  Leu 
    1430     


<210> 1766
<211> 1459
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1189)..(1189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1218)..(1218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1278)..(1278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1356)..(1356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1457)
<223> Selenocysteine

<400> 1766
Met Val Ser Ser Gly Cys Arg Met Arg Ser Leu Trp Phe Ile Ile Val 
1               5                   10                  15      


Ile Ser Phe Leu Pro Asn Xaa Glu Gly Phe Ser Arg Ala Ala Leu Pro 
            20                  25                  30          


Phe Gly Leu Val Arg Arg Glu Leu Ser Cys Glu Gly Tyr Ser Ile Asp 
        35                  40                  45              


Leu Arg Cys Pro Gly Ser Asp Val Ile Met Ile Glu Ser Ala Asn Tyr 
    50                  55                  60                  


Gly Arg Xaa Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu 
65                  70                  75                  80  


Asn Xaa Asp Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Xaa Gln Arg 
                85                  90                  95      


Cys Asn Asn Arg Xaa Gln Cys Ile Val Val Xaa Gly Ser Asp Val Phe 
            100                 105                 110         


Pro Asp Pro Cys Pro Gly Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu 
        115                 120                 125             


Cys Val Pro Tyr Ile Phe Val Cys Pro Gly Xaa Leu Lys Ala Ile Val 
    130                 135                 140                 


Asp Ser Pro Cys Ile Tyr Glu Ala Glu Gln Lys Ala Gly Ala Trp Cys 
145                 150                 155                 160 


Lys Asp Pro Leu Gln Ala Ala Asp Lys Ile Tyr Phe Met Pro Trp Xaa 
                165                 170                 175     


Pro Tyr Arg Xaa Asp Xaa Leu Ile Glu Tyr Ala Ser Leu Glu Asp Phe 
            180                 185                 190         


Gln Asn Ser Arg Gln Xaa Xaa Xaa Tyr Lys Leu Pro Asn Arg Val Asp 
        195                 200                 205             


Gly Xaa Gly Phe Val Val Tyr Asp Gly Ala Val Phe Phe Asn Lys Glu 
    210                 215                 220                 


Arg Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg Ile Lys Ser 
225                 230                 235                 240 


Gly Glu Ala Ile Ile Asn Tyr Ala Asn Tyr His Asp Xaa Ser Pro Tyr 
                245                 250                 255     


Arg Trp Gly Gly Lys Xaa Asp Ile Asp Leu Ala Val Asp Glu Asn Gly 
            260                 265                 270         


Leu Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Met Ile Val Ile 
        275                 280                 285             


Ser Gln Leu Asn Pro Tyr Xaa Leu Arg Phe Glu Ala Xaa Trp Glu Xaa 
    290                 295                 300                 


Val Tyr Asp Lys Arg Ala Ala Ser Asn Ala Phe Met Ile Cys Gly Val 
305                 310                 315                 320 


Leu Tyr Val Val Arg Ser Val Tyr Gln Asp Asn Glu Ser Glu Xaa Gly 
                325                 330                 335     


Lys Asn Ser Ile Asp Tyr Ile Tyr Asn Xaa Arg Leu Asn Arg Gly Glu 
            340                 345                 350         


Tyr Val Asp Val Pro Phe Pro Asn Gln Tyr Gln Tyr Ile Ala Ala Val 
        355                 360                 365             


Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp Asn Asn Asn Phe 
    370                 375                 380                 


Ile Leu Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp Pro Ala Gln Val 
385                 390                 395                 400 


Pro Xaa Xaa Ala Val Xaa Ile Xaa Ser Ser Ala Glu Leu Phe Lys Xaa 
                405                 410                 415     


Ile Ile Ser Xaa Xaa Ser Xaa Xaa Ser Gln Lys Gly Pro Met Ser Xaa 
            420                 425                 430         


Xaa Val Ala Gly Ser Gln Glu Gly Ser Lys Gly Xaa Lys Pro Pro Pro 
        435                 440                 445             


Ala Val Ser Xaa Xaa Lys Ile Pro Pro Ile Xaa Asn Ile Phe Pro Leu 
    450                 455                 460                 


Pro Glu Arg Phe Cys Glu Ala Leu Asp Ser Lys Gly Ile Lys Trp Pro 
465                 470                 475                 480 


Gln Xaa Gln Arg Gly Met Met Val Glu Arg Pro Cys Pro Lys Gly Xaa 
                485                 490                 495     


Arg Gly Xaa Ala Ser Tyr Leu Cys Met Ile Ser Xaa Gly Xaa Trp Asn 
            500                 505                 510         


Pro Lys Gly Pro Asp Leu Ser Asn Cys Xaa Ser His Trp Val Asn Gln 
        515                 520                 525             


Leu Ala Gln Lys Ile Arg Ser Gly Glu Asn Ala Ala Ser Leu Ala Asn 
    530                 535                 540                 


Glu Leu Ala Lys His Xaa Lys Gly Pro Val Phe Ala Gly Asp Val Ser 
545                 550                 555                 560 


Ser Ser Val Arg Leu Met Glu Gln Leu Val Asp Ile Leu Asp Ala Gln 
                565                 570                 575     


Leu Gln Glu Leu Lys Pro Ser Glu Lys Asp Ser Ala Gly Arg Ser Tyr 
            580                 585                 590         


Asn Lys Leu Gln Lys Arg Glu Lys Xaa Cys Arg Ala Tyr Leu Lys Ala 
        595                 600                 605             


Ile Val Asp Xaa Val Asp Asn Leu Leu Arg Pro Glu Ala Leu Glu Ser 
    610                 615                 620                 


Trp Lys His Met Asn Ser Ser Glu Gln Ala His Xaa Ala Xaa Met Leu 
625                 630                 635                 640 


Leu Asp Xaa Leu Glu Glu Gly Ala Phe Val Leu Ala Asp Asn Leu Leu 
                645                 650                 655     


Glu Pro Xaa Arg Val Ser Met Pro Xaa Glu Asn Ile Val Leu Glu Val 
            660                 665                 670         


Ala Val Leu Ser Xaa Glu Gly Gln Ile Gln Asp Phe Lys Phe Pro Leu 
        675                 680                 685             


Gly Ile Lys Gly Ala Gly Ser Ser Ile Gln Leu Ser Ala Asn Xaa Val 
    690                 695                 700                 


Lys Gln Asn Ser Arg Asn Gly Leu Ala Lys Leu Val Phe Ile Ile Tyr 
705                 710                 715                 720 


Arg Ser Leu Gly Gln Phe Leu Ser Xaa Glu Asn Ala Xaa Ile Lys Leu 
                725                 730                 735     


Gly Ala Asp Phe Ile Gly Arg Asn Ser Xaa Ile Ala Val Asn Ser His 
            740                 745                 750         


Val Ile Ser Val Ser Ile Asn Lys Glu Ser Ser Arg Val Tyr Leu Xaa 
        755                 760                 765             


Asp Pro Val Leu Phe Xaa Leu Pro His Ile Asp Pro Asp Asn Tyr Phe 
    770                 775                 780                 


Asn Ala Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg Xaa Met Met Gly 
785                 790                 795                 800 


Tyr Trp Ser Xaa Gln Gly Cys Lys Leu Val Asp Xaa Asn Lys Xaa Arg 
                805                 810                 815     


Xaa Xaa Cys Ala Cys Ser His Leu Xaa Asn Phe Ala Ile Leu Met Ala 
            820                 825                 830         


His Arg Glu Ile Ala Tyr Lys Asp Gly Val His Glu Leu Leu Leu Xaa 
        835                 840                 845             


Val Ile Xaa Trp Val Gly Ile Val Ile Ser Leu Val Cys Leu Ala Ile 
    850                 855                 860                 


Cys Ile Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn 
865                 870                 875                 880 


Xaa Ile His Lys Asn Leu Cys Ile Asn Leu Phe Ile Ala Glu Phe Ile 
                885                 890                 895     


Phe Leu Ile Gly Ile Asp Lys Xaa Lys Tyr Ala Ile Ala Cys Pro Ile 
            900                 905                 910         


Phe Ala Gly Leu Leu His Phe Phe Phe Leu Ala Ala Phe Ala Trp Met 
        915                 920                 925             


Cys Leu Glu Gly Val Gln Leu Tyr Leu Met Leu Val Glu Val Phe Glu 
    930                 935                 940                 


Ser Glu Tyr Ser Arg Lys Lys Tyr Tyr Tyr Val Ala Gly Tyr Leu Phe 
945                 950                 955                 960 


Pro Ala Xaa Val Val Gly Val Ser Ala Ala Ile Asp Tyr Lys Ser Tyr 
                965                 970                 975     


Gly Xaa Glu Lys Ala Cys Trp Leu His Val Asp Asn Tyr Phe Ile Trp 
            980                 985                 990         


Ser Phe Ile Gly Pro Val Xaa Phe  Ile Ile Leu Leu Asn  Ile Ile Phe 
        995                 1000                 1005             


Leu Val  Ile Xaa Leu Cys Lys  Met Val Lys His Ser  Asn Xaa Leu 
    1010                 1015                 1020             


Lys Pro  Asp Ser Ser Arg Leu  Glu Asn Ile Lys Ser  Trp Val Leu 
    1025                 1030                 1035             


Gly Ala  Phe Ala Leu Leu Cys  Leu Leu Gly Leu Xaa  Trp Ser Phe 
    1040                 1045                 1050             


Gly Leu  Leu Phe Ile Asn Glu  Glu Xaa Ile Val Met  Ala Tyr Leu 
    1055                 1060                 1065             


Phe Xaa  Ile Phe Asn Ala Phe  Gln Gly Val Phe Ile  Phe Ile Phe 
    1070                 1075                 1080             


His Cys  Ala Leu Gln Lys Lys  Val Arg Lys Glu Tyr  Gly Lys Cys 
    1085                 1090                 1095             


Phe Arg  His Ser Tyr Cys Cys  Gly Gly Leu Pro Xaa  Glu Ser Pro 
    1100                 1105                 1110             


His Ser  Ser Val Lys Ala Ser  Xaa Xaa Arg Xaa Ser  Ala Arg Tyr 
    1115                 1120                 1125             


Ser Ser  Gly Xaa Gln Ser Arg  Ile Arg Arg Met Trp  Asn Asp Xaa 
    1130                 1135                 1140             


Val Arg  Lys Gln Ser Glu Ser  Ser Phe Ile Ser Gly  Asp Ile Asn 
    1145                 1150                 1155             


Ser Xaa  Ser Xaa Leu Asn Gln  Gly Met Xaa Gly Asn  Tyr Leu Leu 
    1160                 1165                 1170             


Xaa Asn  Pro Leu Leu Arg Pro  His Gly Xaa Asn Asn  Pro Tyr Asn 
    1175                 1180                 1185             


Xaa Leu  Leu Ala Glu Xaa Val  Val Cys Asn Ala Pro  Ser Ala Pro 
    1190                 1195                 1200             


Val Phe  Asn Ser Pro Gly His  Ser Leu Asn Asn Ala  Arg Asp Xaa 
    1205                 1210                 1215             


Ser Ala  Met Asp Xaa Leu Pro  Leu Asn Gly Asn Phe  Asn Asn Ser 
    1220                 1225                 1230             


Tyr Ser  Leu His Lys Gly Asp  Tyr Asn Asp Ser Val  Gln Val Val 
    1235                 1240                 1245             


Asp Cys  Gly Leu Ser Leu Asn  Asp Xaa Ala Phe Glu  Lys Met Ile 
    1250                 1255                 1260             


Ile Ser  Glu Leu Val His Asn  Asn Leu Arg Gly Ser  Ser Lys Xaa 
    1265                 1270                 1275             


His Asn  Leu Glu Leu Xaa Leu  Pro Val Lys Pro Val  Ile Gly Gly 
    1280                 1285                 1290             


Ser Ser  Ser Glu Asp Asp Ala  Ile Val Ala Asp Ala  Ser Ser Leu 
    1295                 1300                 1305             


Met His  Ser Asp Asn Pro Gly  Leu Glu Leu His His  Lys Glu Leu 
    1310                 1315                 1320             


Glu Ala  Pro Leu Ile Pro Gln  Arg Xaa His Ser Leu  Leu Tyr Gln 
    1325                 1330                 1335             


Pro Gln  Lys Lys Val Lys Ser  Glu Gly Xaa Asp Ser  Tyr Val Ser 
    1340                 1345                 1350             


Gln Leu  Xaa Ala Glu Ala Glu  Asp His Leu Gln Ser  Pro Asn Arg 
    1355                 1360                 1365             


Asp Ser  Leu Tyr Xaa Ser Met  Pro Asn Leu Arg Asp  Ser Pro Tyr 
    1370                 1375                 1380             


Pro Glu  Ser Ser Pro Asp Met  Glu Glu Asp Leu Ser  Pro Ser Arg 
    1385                 1390                 1395             


Arg Ser  Glu Asn Glu Asp Ile  Tyr Tyr Lys Ser Met  Pro Asn Leu 
    1400                 1405                 1410             


Gly Ala  Gly His Gln Leu Gln  Met Cys Tyr Gln Ile  Ser Arg Gly 
    1415                 1420                 1425             


Asn Ser  Asp Gly Tyr Ile Ile  Pro Ile Asn Lys Glu  Gly Cys Ile 
    1430                 1435                 1440             


Pro Glu  Gly Asp Val Arg Glu  Gly Gln Met Gln Leu  Val Xaa Ser 
    1445                 1450                 1455             


Leu 
    


<210> 1767
<211> 1461
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1123)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1145)..(1145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1176)..(1176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1191)..(1191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1280)..(1280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1375)..(1375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1459)..(1459)
<223> Selenocysteine

<400> 1767
Met Val Ser Ser Gly Cys Arg Met Arg Ser Leu Trp Phe Ile Ile Val 
1               5                   10                  15      


Ile Ser Phe Leu Pro Asn Xaa Glu Gly Phe Ser Arg Ala Ala Leu Pro 
            20                  25                  30          


Phe Gly Leu Val Arg Arg Glu Leu Ser Cys Glu Gly Tyr Ser Ile Asp 
        35                  40                  45              


Leu Arg Cys Pro Gly Ser Asp Val Ile Met Ile Glu Ser Ala Asn Tyr 
    50                  55                  60                  


Gly Arg Xaa Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu 
65                  70                  75                  80  


Asn Xaa Asp Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Xaa Gln Arg 
                85                  90                  95      


Cys Asn Asn Arg Xaa Gln Cys Ile Val Val Xaa Gly Ser Asp Val Phe 
            100                 105                 110         


Pro Asp Pro Cys Pro Gly Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu 
        115                 120                 125             


Cys Val Pro Tyr Ile Phe Val Cys Pro Gly Xaa Leu Lys Ala Ile Val 
    130                 135                 140                 


Asp Ser Pro Cys Ile Tyr Glu Ala Glu Gln Lys Ala Gly Ala Trp Cys 
145                 150                 155                 160 


Lys Asp Pro Leu Gln Ala Ala Asp Lys Ile Tyr Phe Met Pro Trp Xaa 
                165                 170                 175     


Pro Tyr Arg Xaa Asp Xaa Leu Ile Glu Tyr Ala Ser Leu Glu Asp Phe 
            180                 185                 190         


Gln Asn Ser Arg Gln Xaa Xaa Xaa Tyr Lys Leu Pro Asn Arg Val Asp 
        195                 200                 205             


Gly Xaa Gly Phe Val Val Tyr Asp Gly Ala Val Phe Phe Asn Lys Glu 
    210                 215                 220                 


Arg Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg Ile Lys Ser 
225                 230                 235                 240 


Gly Glu Ala Ile Ile Asn Tyr Ala Asn Tyr His Asp Xaa Ser Pro Tyr 
                245                 250                 255     


Arg Trp Gly Gly Lys Xaa Asp Ile Asp Leu Ala Val Asp Glu Asn Gly 
            260                 265                 270         


Leu Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Met Ile Val Ile 
        275                 280                 285             


Ser Gln Leu Asn Pro Tyr Xaa Leu Arg Phe Glu Ala Xaa Trp Glu Xaa 
    290                 295                 300                 


Val Tyr Asp Lys Arg Ala Ala Ser Asn Ala Phe Met Ile Cys Gly Val 
305                 310                 315                 320 


Leu Tyr Val Val Arg Ser Val Tyr Gln Asp Asn Glu Ser Glu Xaa Gly 
                325                 330                 335     


Lys Asn Ser Ile Asp Tyr Ile Tyr Asn Xaa Arg Leu Asn Arg Gly Glu 
            340                 345                 350         


Tyr Val Asp Val Pro Phe Pro Asn Gln Tyr Gln Tyr Ile Ala Ala Val 
        355                 360                 365             


Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp Asn Asn Asn Phe 
    370                 375                 380                 


Ile Leu Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp Pro Ala Gln Val 
385                 390                 395                 400 


Pro Xaa Xaa Ala Val Xaa Ile Xaa Ser Ser Ala Glu Leu Phe Lys Xaa 
                405                 410                 415     


Ile Ile Ser Xaa Xaa Ser Xaa Xaa Ser Gln Lys Gly Pro Met Ser Xaa 
            420                 425                 430         


Xaa Val Ala Gly Ser Gln Glu Gly Ser Lys Gly Xaa Lys Pro Pro Pro 
        435                 440                 445             


Ala Val Ser Xaa Xaa Lys Ile Pro Pro Ile Xaa Asn Ile Phe Pro Leu 
    450                 455                 460                 


Pro Glu Arg Phe Cys Glu Ala Leu Asp Ser Lys Gly Ile Lys Trp Pro 
465                 470                 475                 480 


Gln Xaa Gln Arg Gly Met Met Val Glu Arg Pro Cys Pro Lys Gly Xaa 
                485                 490                 495     


Arg Gly Xaa Ala Ser Tyr Leu Cys Met Ile Ser Xaa Gly Xaa Trp Asn 
            500                 505                 510         


Pro Lys Gly Pro Asp Leu Ser Asn Cys Xaa Ser His Trp Val Asn Gln 
        515                 520                 525             


Leu Ala Gln Lys Ile Arg Ser Gly Glu Asn Ala Ala Ser Leu Ala Asn 
    530                 535                 540                 


Glu Leu Ala Lys His Xaa Lys Gly Pro Val Phe Ala Gly Asp Val Ser 
545                 550                 555                 560 


Ser Ser Val Arg Leu Met Glu Gln Leu Val Asp Ile Leu Asp Ala Gln 
                565                 570                 575     


Leu Gln Glu Leu Lys Pro Ser Glu Lys Asp Ser Ala Gly Arg Ser Tyr 
            580                 585                 590         


Asn Lys Ala Ile Val Asp Xaa Val Asp Asn Leu Leu Arg Pro Glu Ala 
        595                 600                 605             


Leu Glu Ser Trp Lys His Met Asn Ser Ser Glu Gln Ala His Xaa Ala 
    610                 615                 620                 


Xaa Met Leu Leu Asp Xaa Leu Glu Glu Gly Ala Phe Val Leu Ala Asp 
625                 630                 635                 640 


Asn Leu Leu Glu Pro Xaa Arg Val Ser Met Pro Xaa Glu Asn Ile Val 
                645                 650                 655     


Leu Glu Val Ala Val Leu Ser Xaa Glu Gly Gln Ile Gln Asp Phe Lys 
            660                 665                 670         


Phe Pro Leu Gly Ile Lys Gly Ala Gly Ser Ser Ile Gln Leu Ser Ala 
        675                 680                 685             


Asn Xaa Val Lys Gln Asn Ser Arg Asn Gly Leu Ala Lys Leu Val Phe 
    690                 695                 700                 


Ile Ile Tyr Arg Ser Leu Gly Gln Phe Leu Ser Xaa Glu Asn Ala Xaa 
705                 710                 715                 720 


Ile Lys Leu Gly Ala Asp Phe Ile Gly Arg Asn Ser Xaa Ile Ala Val 
                725                 730                 735     


Asn Ser His Val Ile Ser Val Ser Ile Asn Lys Glu Ser Ser Arg Val 
            740                 745                 750         


Tyr Leu Xaa Asp Pro Val Leu Phe Xaa Leu Pro His Ile Asp Pro Asp 
        755                 760                 765             


Asn Tyr Phe Asn Ala Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg Xaa 
    770                 775                 780                 


Met Met Gly Tyr Trp Ser Xaa Gln Gly Cys Lys Leu Val Asp Xaa Asn 
785                 790                 795                 800 


Lys Xaa Arg Xaa Xaa Cys Ala Cys Ser His Leu Xaa Asn Phe Ala Ile 
                805                 810                 815     


Leu Met Ala His Arg Glu Ile Ala Tyr Lys Asp Gly Val His Glu Leu 
            820                 825                 830         


Leu Leu Xaa Val Ile Xaa Trp Val Gly Ile Val Ile Ser Leu Val Cys 
        835                 840                 845             


Leu Ala Ile Cys Ile Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser 
    850                 855                 860                 


Asp Arg Asn Xaa Ile His Lys Asn Leu Cys Ile Asn Leu Phe Ile Ala 
865                 870                 875                 880 


Glu Phe Ile Phe Leu Ile Gly Ile Asp Lys Xaa Lys Tyr Ala Ile Ala 
                885                 890                 895     


Cys Pro Ile Phe Ala Gly Leu Leu His Phe Phe Phe Leu Ala Ala Phe 
            900                 905                 910         


Ala Trp Met Cys Leu Glu Gly Val Gln Leu Tyr Leu Met Leu Val Glu 
        915                 920                 925             


Val Phe Glu Ser Glu Tyr Ser Arg Lys Lys Tyr Tyr Tyr Val Ala Gly 
    930                 935                 940                 


Tyr Leu Phe Pro Ala Xaa Val Val Gly Val Ser Ala Ala Ile Asp Tyr 
945                 950                 955                 960 


Lys Ser Tyr Gly Xaa Glu Lys Ala Cys Trp Leu His Val Asp Asn Tyr 
                965                 970                 975     


Phe Ile Trp Ser Phe Ile Gly Pro Val Xaa Phe Ile Ile Leu Leu Asn 
            980                 985                 990         


Ile Ile Phe Leu Val Ile Xaa Leu  Cys Lys Met Val Lys  His Ser Asn 
        995                 1000                 1005             


Xaa Leu  Lys Pro Asp Ser Ser  Arg Leu Glu Asn Ile  Asn Asn Tyr 
    1010                 1015                 1020             


Arg Val  Cys Asp Gly Tyr Tyr  Asn Xaa Asp Leu Pro  Gly Ser Trp 
    1025                 1030                 1035             


Val Leu  Gly Ala Phe Ala Leu  Leu Cys Leu Leu Gly  Leu Xaa Trp 
    1040                 1045                 1050             


Ser Phe  Gly Leu Leu Phe Ile  Asn Glu Glu Xaa Ile  Val Met Ala 
    1055                 1060                 1065             


Tyr Leu  Phe Xaa Ile Phe Asn  Ala Phe Gln Gly Val  Phe Ile Phe 
    1070                 1075                 1080             


Ile Phe  His Cys Ala Leu Gln  Lys Lys Val Arg Lys  Glu Tyr Gly 
    1085                 1090                 1095             


Lys Cys  Phe Arg His Ser Tyr  Cys Cys Gly Gly Leu  Pro Xaa Glu 
    1100                 1105                 1110             


Ser Pro  His Ser Ser Val Lys  Ala Ser Xaa Xaa Arg  Xaa Ser Ala 
    1115                 1120                 1125             


Arg Tyr  Ser Ser Gly Xaa Gln  Ser Arg Ile Arg Arg  Met Trp Asn 
    1130                 1135                 1140             


Asp Xaa  Val Arg Lys Gln Ser  Glu Ser Ser Phe Ile  Ser Gly Asp 
    1145                 1150                 1155             


Ile Asn  Ser Xaa Ser Xaa Leu  Asn Gln Gly Met Xaa  Gly Asn Tyr 
    1160                 1165                 1170             


Leu Leu  Xaa Asn Pro Leu Leu  Arg Pro His Gly Xaa  Asn Asn Pro 
    1175                 1180                 1185             


Tyr Asn  Xaa Leu Leu Ala Glu  Xaa Val Val Cys Asn  Ala Pro Ser 
    1190                 1195                 1200             


Ala Pro  Val Phe Asn Ser Pro  Gly His Ser Leu Asn  Asn Ala Arg 
    1205                 1210                 1215             


Asp Xaa  Ser Ala Met Asp Xaa  Leu Pro Leu Asn Gly  Asn Phe Asn 
    1220                 1225                 1230             


Asn Ser  Tyr Ser Leu His Lys  Gly Asp Tyr Asn Asp  Ser Val Gln 
    1235                 1240                 1245             


Val Val  Asp Cys Gly Leu Ser  Leu Asn Asp Xaa Ala  Phe Glu Lys 
    1250                 1255                 1260             


Met Ile  Ile Ser Glu Leu Val  His Asn Asn Leu Arg  Gly Ser Ser 
    1265                 1270                 1275             


Lys Xaa  His Asn Leu Glu Leu  Xaa Leu Pro Val Lys  Pro Val Ile 
    1280                 1285                 1290             


Gly Gly  Ser Ser Ser Glu Asp  Asp Ala Ile Val Ala  Asp Ala Ser 
    1295                 1300                 1305             


Ser Leu  Met His Ser Asp Asn  Pro Gly Leu Glu Leu  His His Lys 
    1310                 1315                 1320             


Glu Leu  Glu Ala Pro Leu Ile  Pro Gln Arg Xaa His  Ser Leu Leu 
    1325                 1330                 1335             


Tyr Gln  Pro Gln Lys Lys Val  Lys Ser Glu Gly Xaa  Asp Ser Tyr 
    1340                 1345                 1350             


Val Ser  Gln Leu Xaa Ala Glu  Ala Glu Asp His Leu  Gln Ser Pro 
    1355                 1360                 1365             


Asn Arg  Asp Ser Leu Tyr Xaa  Ser Met Pro Asn Leu  Arg Asp Ser 
    1370                 1375                 1380             


Pro Tyr  Pro Glu Ser Ser Pro  Asp Met Glu Glu Asp  Leu Ser Pro 
    1385                 1390                 1395             


Ser Arg  Arg Ser Glu Asn Glu  Asp Ile Tyr Tyr Lys  Ser Met Pro 
    1400                 1405                 1410             


Asn Leu  Gly Ala Gly His Gln  Leu Gln Met Cys Tyr  Gln Ile Ser 
    1415                 1420                 1425             


Arg Gly  Asn Ser Asp Gly Tyr  Ile Ile Pro Ile Asn  Lys Glu Gly 
    1430                 1435                 1440             


Cys Ile  Pro Glu Gly Asp Val  Arg Glu Gly Gln Met  Gln Leu Val 
    1445                 1450                 1455             


Xaa Ser  Leu 
    1460     


<210> 1768
<211> 1474
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1189)..(1189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1238)..(1238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1272)..(1272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1293)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1299)..(1299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1347)..(1347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1363)..(1363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1388)..(1388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<400> 1768
Met Val Ser Ser Gly Cys Arg Met Arg Ser Leu Trp Phe Ile Ile Val 
1               5                   10                  15      


Ile Ser Phe Leu Pro Asn Xaa Glu Gly Phe Ser Arg Ala Ala Leu Pro 
            20                  25                  30          


Phe Gly Leu Val Arg Arg Glu Leu Ser Cys Glu Gly Tyr Ser Ile Asp 
        35                  40                  45              


Leu Arg Cys Pro Gly Ser Asp Val Ile Met Ile Glu Ser Ala Asn Tyr 
    50                  55                  60                  


Gly Arg Xaa Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu 
65                  70                  75                  80  


Asn Xaa Asp Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Xaa Gln Arg 
                85                  90                  95      


Cys Asn Asn Arg Xaa Gln Cys Ile Val Val Xaa Gly Ser Asp Val Phe 
            100                 105                 110         


Pro Asp Pro Cys Pro Gly Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu 
        115                 120                 125             


Cys Val Pro Tyr Ile Phe Val Cys Pro Gly Xaa Leu Lys Ala Ile Val 
    130                 135                 140                 


Asp Ser Pro Cys Ile Tyr Glu Ala Glu Gln Lys Ala Gly Ala Trp Cys 
145                 150                 155                 160 


Lys Asp Pro Leu Gln Ala Ala Asp Lys Ile Tyr Phe Met Pro Trp Xaa 
                165                 170                 175     


Pro Tyr Arg Xaa Asp Xaa Leu Ile Glu Tyr Ala Ser Leu Glu Asp Phe 
            180                 185                 190         


Gln Asn Ser Arg Gln Xaa Xaa Xaa Tyr Lys Leu Pro Asn Arg Val Asp 
        195                 200                 205             


Gly Xaa Gly Phe Val Val Tyr Asp Gly Ala Val Phe Phe Asn Lys Glu 
    210                 215                 220                 


Arg Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg Ile Lys Ser 
225                 230                 235                 240 


Gly Glu Ala Ile Ile Asn Tyr Ala Asn Tyr His Asp Xaa Ser Pro Tyr 
                245                 250                 255     


Arg Trp Gly Gly Lys Xaa Asp Ile Asp Leu Ala Val Asp Glu Asn Gly 
            260                 265                 270         


Leu Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Met Ile Val Ile 
        275                 280                 285             


Ser Gln Leu Asn Pro Tyr Xaa Leu Arg Phe Glu Ala Xaa Trp Glu Xaa 
    290                 295                 300                 


Val Tyr Asp Lys Arg Ala Ala Ser Asn Ala Phe Met Ile Cys Gly Val 
305                 310                 315                 320 


Leu Tyr Val Val Arg Ser Val Tyr Gln Asp Asn Glu Ser Glu Xaa Gly 
                325                 330                 335     


Lys Asn Ser Ile Asp Tyr Ile Tyr Asn Xaa Arg Leu Asn Arg Gly Glu 
            340                 345                 350         


Tyr Val Asp Val Pro Phe Pro Asn Gln Tyr Gln Tyr Ile Ala Ala Val 
        355                 360                 365             


Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp Asn Asn Asn Phe 
    370                 375                 380                 


Ile Leu Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp Pro Ala Gln Val 
385                 390                 395                 400 


Pro Xaa Xaa Ala Val Xaa Ile Xaa Ser Ser Ala Glu Leu Phe Lys Xaa 
                405                 410                 415     


Ile Ile Ser Xaa Xaa Ser Xaa Xaa Ser Gln Lys Gly Pro Met Ser Xaa 
            420                 425                 430         


Xaa Val Ala Gly Ser Gln Glu Gly Ser Lys Gly Xaa Lys Pro Pro Pro 
        435                 440                 445             


Ala Val Ser Xaa Xaa Lys Ile Pro Pro Ile Xaa Asn Ile Phe Pro Leu 
    450                 455                 460                 


Pro Glu Arg Phe Cys Glu Ala Leu Asp Ser Lys Gly Ile Lys Trp Pro 
465                 470                 475                 480 


Gln Xaa Gln Arg Gly Met Met Val Glu Arg Pro Cys Pro Lys Gly Xaa 
                485                 490                 495     


Arg Gly Xaa Ala Ser Tyr Leu Cys Met Ile Ser Xaa Gly Xaa Trp Asn 
            500                 505                 510         


Pro Lys Gly Pro Asp Leu Ser Asn Cys Xaa Ser His Trp Val Asn Gln 
        515                 520                 525             


Leu Ala Gln Lys Ile Arg Ser Gly Glu Asn Ala Ala Ser Leu Ala Asn 
    530                 535                 540                 


Glu Leu Ala Lys His Xaa Lys Gly Pro Val Phe Ala Gly Asp Val Ser 
545                 550                 555                 560 


Ser Ser Val Arg Leu Met Glu Gln Leu Val Asp Ile Leu Asp Ala Gln 
                565                 570                 575     


Leu Gln Glu Leu Lys Pro Ser Glu Lys Asp Ser Ala Gly Arg Ser Tyr 
            580                 585                 590         


Asn Lys Leu Gln Lys Arg Glu Lys Xaa Cys Arg Ala Tyr Leu Lys Ala 
        595                 600                 605             


Ile Val Asp Xaa Val Asp Asn Leu Leu Arg Pro Glu Ala Leu Glu Ser 
    610                 615                 620                 


Trp Lys His Met Asn Ser Ser Glu Gln Ala His Xaa Ala Xaa Met Leu 
625                 630                 635                 640 


Leu Asp Xaa Leu Glu Glu Gly Ala Phe Val Leu Ala Asp Asn Leu Leu 
                645                 650                 655     


Glu Pro Xaa Arg Val Ser Met Pro Xaa Glu Asn Ile Val Leu Glu Val 
            660                 665                 670         


Ala Val Leu Ser Xaa Glu Gly Gln Ile Gln Asp Phe Lys Phe Pro Leu 
        675                 680                 685             


Gly Ile Lys Gly Ala Gly Ser Ser Ile Gln Leu Ser Ala Asn Xaa Val 
    690                 695                 700                 


Lys Gln Asn Ser Arg Asn Gly Leu Ala Lys Leu Val Phe Ile Ile Tyr 
705                 710                 715                 720 


Arg Ser Leu Gly Gln Phe Leu Ser Xaa Glu Asn Ala Xaa Ile Lys Leu 
                725                 730                 735     


Gly Ala Asp Phe Ile Gly Arg Asn Ser Xaa Ile Ala Val Asn Ser His 
            740                 745                 750         


Val Ile Ser Val Ser Ile Asn Lys Glu Ser Ser Arg Val Tyr Leu Xaa 
        755                 760                 765             


Asp Pro Val Leu Phe Xaa Leu Pro His Ile Asp Pro Asp Asn Tyr Phe 
    770                 775                 780                 


Asn Ala Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg Xaa Met Met Gly 
785                 790                 795                 800 


Tyr Trp Ser Xaa Gln Gly Cys Lys Leu Val Asp Xaa Asn Lys Xaa Arg 
                805                 810                 815     


Xaa Xaa Cys Ala Cys Ser His Leu Xaa Asn Phe Ala Ile Leu Met Ala 
            820                 825                 830         


His Arg Glu Ile Ala Tyr Lys Asp Gly Val His Glu Leu Leu Leu Xaa 
        835                 840                 845             


Val Ile Xaa Trp Val Gly Ile Val Ile Ser Leu Val Cys Leu Ala Ile 
    850                 855                 860                 


Cys Ile Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn 
865                 870                 875                 880 


Xaa Ile His Lys Asn Leu Cys Ile Asn Leu Phe Ile Ala Glu Phe Ile 
                885                 890                 895     


Phe Leu Ile Gly Ile Asp Lys Xaa Lys Tyr Ala Ile Ala Cys Pro Ile 
            900                 905                 910         


Phe Ala Gly Leu Leu His Phe Phe Phe Leu Ala Ala Phe Ala Trp Met 
        915                 920                 925             


Cys Leu Glu Gly Val Gln Leu Tyr Leu Met Leu Val Glu Val Phe Glu 
    930                 935                 940                 


Ser Glu Tyr Ser Arg Lys Lys Tyr Tyr Tyr Val Ala Gly Tyr Leu Phe 
945                 950                 955                 960 


Pro Ala Xaa Val Val Gly Val Ser Ala Ala Ile Asp Tyr Lys Ser Tyr 
                965                 970                 975     


Gly Xaa Glu Lys Ala Cys Trp Leu His Val Asp Asn Tyr Phe Ile Trp 
            980                 985                 990         


Ser Phe Ile Gly Pro Val Xaa Phe  Ile Ile Leu Leu Asn  Ile Ile Phe 
        995                 1000                 1005             


Leu Val  Ile Xaa Leu Cys Lys  Met Val Lys His Ser  Asn Xaa Leu 
    1010                 1015                 1020             


Lys Pro  Asp Ser Ser Arg Leu  Glu Asn Ile Asn Asn  Tyr Arg Val 
    1025                 1030                 1035             


Cys Asp  Gly Tyr Tyr Asn Xaa  Asp Leu Pro Gly Ser  Trp Val Leu 
    1040                 1045                 1050             


Gly Ala  Phe Ala Leu Leu Cys  Leu Leu Gly Leu Xaa  Trp Ser Phe 
    1055                 1060                 1065             


Gly Leu  Leu Phe Ile Asn Glu  Glu Xaa Ile Val Met  Ala Tyr Leu 
    1070                 1075                 1080             


Phe Xaa  Ile Phe Asn Ala Phe  Gln Gly Val Phe Ile  Phe Ile Phe 
    1085                 1090                 1095             


His Cys  Ala Leu Gln Lys Lys  Val Arg Lys Glu Tyr  Gly Lys Cys 
    1100                 1105                 1110             


Phe Arg  His Ser Tyr Cys Cys  Gly Gly Leu Pro Xaa  Glu Ser Pro 
    1115                 1120                 1125             


His Ser  Ser Val Lys Ala Ser  Xaa Xaa Arg Xaa Ser  Ala Arg Tyr 
    1130                 1135                 1140             


Ser Ser  Gly Xaa Gln Ser Arg  Ile Arg Arg Met Trp  Asn Asp Xaa 
    1145                 1150                 1155             


Val Arg  Lys Gln Ser Glu Ser  Ser Phe Ile Ser Gly  Asp Ile Asn 
    1160                 1165                 1170             


Ser Xaa  Ser Xaa Leu Asn Gln  Gly Met Xaa Gly Asn  Tyr Leu Leu 
    1175                 1180                 1185             


Xaa Asn  Pro Leu Leu Arg Pro  His Gly Xaa Asn Asn  Pro Tyr Asn 
    1190                 1195                 1200             


Xaa Leu  Leu Ala Glu Xaa Val  Val Cys Asn Ala Pro  Ser Ala Pro 
    1205                 1210                 1215             


Val Phe  Asn Ser Pro Gly His  Ser Leu Asn Asn Ala  Arg Asp Xaa 
    1220                 1225                 1230             


Ser Ala  Met Asp Xaa Leu Pro  Leu Asn Gly Asn Phe  Asn Asn Ser 
    1235                 1240                 1245             


Tyr Ser  Leu His Lys Gly Asp  Tyr Asn Asp Ser Val  Gln Val Val 
    1250                 1255                 1260             


Asp Cys  Gly Leu Ser Leu Asn  Asp Xaa Ala Phe Glu  Lys Met Ile 
    1265                 1270                 1275             


Ile Ser  Glu Leu Val His Asn  Asn Leu Arg Gly Ser  Ser Lys Xaa 
    1280                 1285                 1290             


His Asn  Leu Glu Leu Xaa Leu  Pro Val Lys Pro Val  Ile Gly Gly 
    1295                 1300                 1305             


Ser Ser  Ser Glu Asp Asp Ala  Ile Val Ala Asp Ala  Ser Ser Leu 
    1310                 1315                 1320             


Met His  Ser Asp Asn Pro Gly  Leu Glu Leu His His  Lys Glu Leu 
    1325                 1330                 1335             


Glu Ala  Pro Leu Ile Pro Gln  Arg Xaa His Ser Leu  Leu Tyr Gln 
    1340                 1345                 1350             


Pro Gln  Lys Lys Val Lys Ser  Glu Gly Xaa Asp Ser  Tyr Val Ser 
    1355                 1360                 1365             


Gln Leu  Xaa Ala Glu Ala Glu  Asp His Leu Gln Ser  Pro Asn Arg 
    1370                 1375                 1380             


Asp Ser  Leu Tyr Xaa Ser Met  Pro Asn Leu Arg Asp  Ser Pro Tyr 
    1385                 1390                 1395             


Pro Glu  Ser Ser Pro Asp Met  Glu Glu Asp Leu Ser  Pro Ser Arg 
    1400                 1405                 1410             


Arg Ser  Glu Asn Glu Asp Ile  Tyr Tyr Lys Ser Met  Pro Asn Leu 
    1415                 1420                 1425             


Gly Ala  Gly His Gln Leu Gln  Met Cys Tyr Gln Ile  Ser Arg Gly 
    1430                 1435                 1440             


Asn Ser  Asp Gly Tyr Ile Ile  Pro Ile Asn Lys Glu  Gly Cys Ile 
    1445                 1450                 1455             


Pro Glu  Gly Asp Val Arg Glu  Gly Gln Met Gln Leu  Val Xaa Ser 
    1460                 1465                 1470             


Leu 
    


<210> 1769
<211> 1384
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1093)..(1093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1108)..(1108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1273)..(1273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1281)..(1281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1298)..(1298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1382)..(1382)
<223> Selenocysteine

<400> 1769
Met Val Ser Ser Gly Cys Arg Met Arg Ser Leu Trp Phe Ile Ile Val 
1               5                   10                  15      


Ile Ser Phe Leu Pro Asn Xaa Glu Gly Phe Ser Arg Ala Ala Leu Pro 
            20                  25                  30          


Phe Gly Leu Val Arg Arg Glu Leu Ser Cys Glu Gly Tyr Ser Ile Asp 
        35                  40                  45              


Leu Arg Cys Pro Gly Ser Asp Val Ile Met Ile Glu Ser Ala Asn Tyr 
    50                  55                  60                  


Gly Arg Xaa Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu 
65                  70                  75                  80  


Asn Xaa Asp Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Xaa Gln Arg 
                85                  90                  95      


Cys Asn Asn Arg Xaa Gln Cys Ile Val Val Xaa Gly Ser Asp Val Phe 
            100                 105                 110         


Pro Asp Pro Cys Pro Gly Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu 
        115                 120                 125             


Cys Val Pro Tyr Met Glu Gln Lys Val Phe Val Cys Pro Gly Xaa Leu 
    130                 135                 140                 


Lys Ala Ile Val Asp Ser Pro Cys Ile Tyr Glu Ala Glu Gln Lys Ala 
145                 150                 155                 160 


Gly Ala Trp Cys Lys Asp Pro Leu Gln Ala Ala Asp Lys Ile Tyr Phe 
                165                 170                 175     


Met Pro Trp Xaa Pro Tyr Arg Xaa Asp Xaa Leu Ile Glu Tyr Ala Ser 
            180                 185                 190         


Leu Glu Asp Phe Gln Asn Ser Arg Gln Xaa Xaa Xaa Tyr Lys Leu Pro 
        195                 200                 205             


Asn Arg Val Asp Gly Xaa Gly Phe Val Val Tyr Asp Gly Ala Val Phe 
    210                 215                 220                 


Phe Asn Lys Glu Arg Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa 
225                 230                 235                 240 


Arg Ile Lys Ser Gly Glu Ala Ile Ile Asn Tyr Ala Asn Tyr His Asp 
                245                 250                 255     


Xaa Ser Pro Tyr Arg Trp Gly Gly Lys Xaa Asp Ile Asp Leu Ala Val 
            260                 265                 270         


Asp Glu Asn Gly Leu Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly 
        275                 280                 285             


Met Ile Val Ile Ser Gln Leu Asn Pro Tyr Xaa Leu Arg Phe Glu Ala 
    290                 295                 300                 


Xaa Trp Glu Xaa Val Tyr Asp Lys Arg Ala Ala Ser Asn Ala Phe Met 
305                 310                 315                 320 


Ile Cys Gly Val Leu Tyr Val Val Arg Ser Val Tyr Gln Asp Asn Glu 
                325                 330                 335     


Ser Glu Xaa Gly Lys Asn Ser Ile Asp Tyr Ile Tyr Asn Xaa Arg Leu 
            340                 345                 350         


Asn Arg Gly Glu Tyr Val Asp Val Pro Phe Pro Asn Gln Tyr Gln Tyr 
        355                 360                 365             


Ile Ala Ala Val Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp 
    370                 375                 380                 


Asn Asn Asn Phe Ile Leu Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp 
385                 390                 395                 400 


Pro Ala Gln Glu Arg Phe Cys Glu Ala Leu Asp Ser Lys Gly Ile Lys 
                405                 410                 415     


Trp Pro Gln Xaa Gln Arg Gly Met Met Val Glu Arg Pro Cys Pro Lys 
            420                 425                 430         


Gly Xaa Arg Gly Xaa Ala Ser Tyr Leu Cys Met Ile Ser Xaa Gly Xaa 
        435                 440                 445             


Trp Asn Pro Lys Gly Pro Asp Leu Ser Asn Cys Xaa Ser His Trp Val 
    450                 455                 460                 


Asn Gln Leu Ala Gln Lys Ile Arg Ser Gly Glu Asn Ala Ala Ser Leu 
465                 470                 475                 480 


Ala Asn Glu Leu Ala Lys His Xaa Lys Gly Pro Val Phe Ala Gly Asp 
                485                 490                 495     


Val Ser Ser Ser Val Arg Leu Met Glu Gln Leu Val Asp Ile Leu Asp 
            500                 505                 510         


Ala Gln Leu Gln Glu Leu Lys Pro Ser Glu Lys Asp Ser Ala Gly Arg 
        515                 520                 525             


Ser Tyr Asn Lys Ala Ile Val Asp Xaa Val Asp Asn Leu Leu Arg Pro 
    530                 535                 540                 


Glu Ala Leu Glu Ser Trp Lys His Met Asn Ser Ser Glu Gln Ala His 
545                 550                 555                 560 


Xaa Ala Xaa Met Leu Leu Asp Xaa Leu Glu Glu Gly Ala Phe Val Leu 
                565                 570                 575     


Ala Asp Asn Leu Leu Glu Pro Xaa Arg Val Ser Met Pro Xaa Glu Asn 
            580                 585                 590         


Ile Val Leu Glu Val Ala Val Leu Ser Xaa Glu Gly Gln Ile Gln Asp 
        595                 600                 605             


Phe Lys Phe Pro Leu Gly Ile Lys Gly Ala Gly Ser Ser Ile Gln Leu 
    610                 615                 620                 


Ser Ala Asn Xaa Val Lys Gln Asn Ser Arg Asn Gly Leu Ala Lys Leu 
625                 630                 635                 640 


Val Phe Ile Ile Tyr Arg Ser Leu Gly Gln Phe Leu Ser Xaa Glu Asn 
                645                 650                 655     


Ala Xaa Ile Lys Leu Gly Ala Asp Phe Ile Gly Arg Asn Ser Xaa Ile 
            660                 665                 670         


Ala Val Asn Ser His Val Ile Ser Val Ser Ile Asn Lys Glu Ser Ser 
        675                 680                 685             


Arg Val Tyr Leu Xaa Asp Pro Val Leu Phe Xaa Leu Pro His Ile Asp 
    690                 695                 700                 


Pro Asp Asn Tyr Phe Asn Ala Asn Cys Ser Phe Trp Asn Tyr Ser Glu 
705                 710                 715                 720 


Arg Xaa Met Met Gly Tyr Trp Ser Xaa Gln Gly Cys Lys Leu Val Asp 
                725                 730                 735     


Xaa Asn Lys Xaa Arg Xaa Xaa Cys Ala Cys Ser His Leu Xaa Asn Phe 
            740                 745                 750         


Ala Ile Leu Met Ala His Arg Glu Ile Ala Tyr Lys Asp Gly Val His 
        755                 760                 765             


Glu Leu Leu Leu Xaa Val Ile Xaa Trp Val Gly Ile Val Ile Ser Leu 
    770                 775                 780                 


Val Cys Leu Ala Ile Cys Ile Phe Xaa Phe Cys Phe Phe Arg Gly Leu 
785                 790                 795                 800 


Gln Ser Asp Arg Asn Xaa Ile His Lys Asn Leu Cys Ile Asn Leu Phe 
                805                 810                 815     


Ile Ala Glu Phe Ile Phe Leu Ile Gly Ile Asp Lys Xaa Lys Tyr Ala 
            820                 825                 830         


Ile Ala Cys Pro Ile Phe Ala Gly Leu Leu His Phe Phe Phe Leu Ala 
        835                 840                 845             


Ala Phe Ala Trp Met Cys Leu Glu Gly Val Gln Leu Tyr Leu Met Leu 
    850                 855                 860                 


Val Glu Val Phe Glu Ser Glu Tyr Ser Arg Lys Lys Tyr Tyr Tyr Val 
865                 870                 875                 880 


Ala Gly Tyr Leu Phe Pro Ala Xaa Val Val Gly Val Ser Ala Ala Ile 
                885                 890                 895     


Asp Tyr Lys Ser Tyr Gly Xaa Glu Lys Ala Cys Trp Leu His Val Asp 
            900                 905                 910         


Asn Tyr Phe Ile Trp Ser Phe Ile Gly Pro Val Xaa Phe Ile Ile Leu 
        915                 920                 925             


Leu Asn Ile Ile Phe Leu Val Ile Xaa Leu Cys Lys Met Val Lys His 
    930                 935                 940                 


Ser Asn Xaa Leu Lys Pro Asp Ser Ser Arg Leu Glu Asn Ile Lys Ser 
945                 950                 955                 960 


Trp Val Leu Gly Ala Phe Ala Leu Leu Cys Leu Leu Gly Leu Xaa Trp 
                965                 970                 975     


Ser Phe Gly Leu Leu Phe Ile Asn Glu Glu Xaa Ile Val Met Ala Tyr 
            980                 985                 990         


Leu Phe Xaa Ile Phe Asn Ala Phe  Gln Gly Val Phe Ile  Phe Ile Phe 
        995                 1000                 1005             


His Cys  Ala Leu Gln Lys Lys  Val Arg Lys Glu Tyr  Gly Lys Cys 
    1010                 1015                 1020             


Phe Arg  His Ser Tyr Cys Cys  Gly Gly Leu Pro Xaa  Glu Ser Pro 
    1025                 1030                 1035             


His Ser  Ser Val Lys Ala Ser  Xaa Xaa Arg Xaa Ser  Ala Arg Tyr 
    1040                 1045                 1050             


Ser Ser  Gly Xaa Gln Ser Arg  Ile Arg Arg Met Trp  Asn Asp Xaa 
    1055                 1060                 1065             


Val Arg  Lys Gln Ser Glu Ser  Ser Phe Ile Ser Gly  Asp Ile Asn 
    1070                 1075                 1080             


Ser Xaa  Ser Xaa Leu Asn Gln  Gly Met Xaa Gly Asn  Tyr Leu Leu 
    1085                 1090                 1095             


Xaa Asn  Pro Leu Leu Arg Pro  His Gly Xaa Asn Asn  Pro Tyr Asn 
    1100                 1105                 1110             


Xaa Leu  Leu Ala Glu Xaa Val  Val Cys Asn Ala Pro  Ser Ala Pro 
    1115                 1120                 1125             


Val Phe  Asn Ser Pro Gly His  Ser Leu Asn Asn Ala  Arg Asp Xaa 
    1130                 1135                 1140             


Ser Ala  Met Asp Xaa Leu Pro  Leu Asn Gly Asn Phe  Asn Asn Ser 
    1145                 1150                 1155             


Tyr Ser  Leu His Lys Gly Asp  Tyr Asn Asp Ser Val  Gln Val Val 
    1160                 1165                 1170             


Asp Cys  Gly Leu Ser Leu Asn  Asp Xaa Ala Phe Glu  Lys Met Ile 
    1175                 1180                 1185             


Ile Ser  Glu Leu Val His Asn  Asn Leu Arg Gly Ser  Ser Lys Xaa 
    1190                 1195                 1200             


His Asn  Leu Glu Leu Xaa Leu  Pro Val Lys Pro Val  Ile Gly Gly 
    1205                 1210                 1215             


Ser Ser  Ser Glu Asp Asp Ala  Ile Val Ala Asp Ala  Ser Ser Leu 
    1220                 1225                 1230             


Met His  Ser Asp Asn Pro Gly  Leu Glu Leu His His  Lys Glu Leu 
    1235                 1240                 1245             


Glu Ala  Pro Leu Ile Pro Gln  Arg Xaa His Ser Leu  Leu Tyr Gln 
    1250                 1255                 1260             


Pro Gln  Lys Lys Val Lys Ser  Glu Gly Xaa Asp Ser  Tyr Val Ser 
    1265                 1270                 1275             


Gln Leu  Xaa Ala Glu Ala Glu  Asp His Leu Gln Ser  Pro Asn Arg 
    1280                 1285                 1290             


Asp Ser  Leu Tyr Xaa Ser Met  Pro Asn Leu Arg Asp  Ser Pro Tyr 
    1295                 1300                 1305             


Pro Glu  Ser Ser Pro Asp Met  Glu Glu Asp Leu Ser  Pro Ser Arg 
    1310                 1315                 1320             


Arg Ser  Glu Asn Glu Asp Ile  Tyr Tyr Lys Ser Met  Pro Asn Leu 
    1325                 1330                 1335             


Gly Ala  Gly His Gln Leu Gln  Met Cys Tyr Gln Ile  Ser Arg Gly 
    1340                 1345                 1350             


Asn Ser  Asp Gly Tyr Ile Ile  Pro Ile Asn Lys Glu  Gly Cys Ile 
    1355                 1360                 1365             


Pro Glu  Gly Asp Val Arg Glu  Gly Gln Met Gln Leu  Val Xaa Ser 
    1370                 1375                 1380             


Leu 
    


<210> 1770
<211> 1351
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1066)..(1066)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1176)..(1176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1224)..(1224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1240)..(1240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1248)..(1248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1349)..(1349)
<223> Selenocysteine

<400> 1770
Xaa Phe Val Cys Pro Gly Xaa Leu Lys Ala Ile Val Asp Ser Pro Cys 
1               5                   10                  15      


Ile Tyr Glu Ala Glu Gln Lys Ala Gly Ala Trp Cys Lys Asp Pro Leu 
            20                  25                  30          


Gln Ala Ala Asp Lys Ile Tyr Phe Met Pro Trp Xaa Pro Tyr Arg Xaa 
        35                  40                  45              


Asp Xaa Leu Ile Glu Tyr Ala Ser Leu Glu Asp Phe Gln Asn Ser Arg 
    50                  55                  60                  


Gln Xaa Xaa Xaa Tyr Lys Leu Pro Asn Arg Val Asp Gly Xaa Gly Phe 
65                  70                  75                  80  


Val Val Tyr Asp Gly Ala Val Phe Phe Asn Lys Glu Arg Xaa Arg Asn 
                85                  90                  95      


Ile Val Lys Phe Asp Leu Arg Xaa Arg Ile Lys Ser Gly Glu Ala Ile 
            100                 105                 110         


Ile Asn Tyr Ala Asn Tyr His Asp Xaa Ser Pro Tyr Arg Trp Gly Gly 
        115                 120                 125             


Lys Xaa Asp Ile Asp Leu Ala Val Asp Glu Asn Gly Leu Trp Val Ile 
    130                 135                 140                 


Tyr Ala Xaa Glu Gln Asn Asn Gly Met Ile Val Ile Ser Gln Leu Asn 
145                 150                 155                 160 


Pro Tyr Xaa Leu Arg Phe Glu Ala Xaa Trp Glu Xaa Val Tyr Asp Lys 
                165                 170                 175     


Arg Ala Ala Ser Asn Ala Phe Met Ile Cys Gly Val Leu Tyr Val Val 
            180                 185                 190         


Arg Ser Val Tyr Gln Asp Asn Glu Ser Glu Xaa Gly Lys Asn Ser Ile 
        195                 200                 205             


Asp Tyr Ile Tyr Asn Xaa Arg Leu Asn Arg Gly Glu Tyr Val Asp Val 
    210                 215                 220                 


Pro Phe Pro Asn Gln Tyr Gln Tyr Ile Ala Ala Val Asp Tyr Asn Pro 
225                 230                 235                 240 


Arg Asp Asn Gln Leu Tyr Val Trp Asn Asn Asn Phe Ile Leu Arg Tyr 
                245                 250                 255     


Ser Leu Glu Phe Gly Pro Pro Asp Pro Ala Gln Val Pro Xaa Xaa Ala 
            260                 265                 270         


Val Xaa Ile Xaa Ser Ser Ala Glu Leu Phe Lys Xaa Ile Ile Ser Xaa 
        275                 280                 285             


Xaa Ser Xaa Xaa Ser Gln Lys Gly Pro Met Ser Xaa Xaa Val Ala Gly 
    290                 295                 300                 


Ser Gln Glu Gly Ser Lys Gly Xaa Lys Pro Pro Pro Ala Val Ser Xaa 
305                 310                 315                 320 


Xaa Lys Ile Pro Pro Ile Xaa Asn Ile Phe Pro Leu Pro Glu Arg Phe 
                325                 330                 335     


Cys Glu Ala Leu Asp Ser Lys Gly Ile Lys Trp Pro Gln Xaa Gln Arg 
            340                 345                 350         


Gly Met Met Val Glu Arg Pro Cys Pro Lys Gly Xaa Arg Gly Xaa Ala 
        355                 360                 365             


Ser Tyr Leu Cys Met Ile Ser Xaa Gly Xaa Trp Asn Pro Lys Gly Pro 
    370                 375                 380                 


Asp Leu Ser Asn Cys Xaa Ser His Trp Val Asn Gln Leu Ala Gln Lys 
385                 390                 395                 400 


Ile Arg Ser Gly Glu Asn Ala Ala Ser Leu Ala Asn Glu Leu Ala Lys 
                405                 410                 415     


His Xaa Lys Gly Pro Val Phe Ala Gly Asp Val Ser Ser Ser Val Arg 
            420                 425                 430         


Leu Met Glu Gln Leu Val Asp Ile Leu Asp Ala Gln Leu Gln Glu Leu 
        435                 440                 445             


Lys Pro Ser Glu Lys Asp Ser Ala Gly Arg Ser Tyr Asn Lys Leu Gln 
    450                 455                 460                 


Lys Arg Glu Lys Xaa Cys Arg Ala Tyr Leu Lys Ala Ile Val Asp Xaa 
465                 470                 475                 480 


Val Asp Asn Leu Leu Arg Pro Glu Ala Leu Glu Ser Trp Lys His Met 
                485                 490                 495     


Asn Ser Ser Glu Gln Ala His Xaa Ala Xaa Met Leu Leu Asp Xaa Leu 
            500                 505                 510         


Glu Glu Gly Ala Phe Val Leu Ala Asp Asn Leu Leu Glu Pro Xaa Arg 
        515                 520                 525             


Val Ser Met Pro Xaa Glu Asn Ile Val Leu Glu Val Ala Val Leu Ser 
    530                 535                 540                 


Xaa Glu Gly Gln Ile Gln Asp Phe Lys Phe Pro Leu Gly Ile Lys Gly 
545                 550                 555                 560 


Ala Gly Ser Ser Ile Gln Leu Ser Ala Asn Xaa Val Lys Gln Asn Ser 
                565                 570                 575     


Arg Asn Gly Leu Ala Lys Leu Val Phe Ile Ile Tyr Arg Ser Leu Gly 
            580                 585                 590         


Gln Phe Leu Ser Xaa Glu Asn Ala Xaa Ile Lys Leu Gly Ala Asp Phe 
        595                 600                 605             


Ile Gly Arg Asn Ser Xaa Ile Ala Val Asn Ser His Val Ile Ser Val 
    610                 615                 620                 


Ser Ile Asn Lys Glu Ser Ser Arg Val Tyr Leu Xaa Asp Pro Val Leu 
625                 630                 635                 640 


Phe Xaa Leu Pro His Ile Asp Pro Asp Asn Tyr Phe Asn Ala Asn Cys 
                645                 650                 655     


Ser Phe Trp Asn Tyr Ser Glu Arg Xaa Met Met Gly Tyr Trp Ser Xaa 
            660                 665                 670         


Gln Gly Cys Lys Leu Val Asp Xaa Asn Lys Xaa Arg Xaa Xaa Cys Ala 
        675                 680                 685             


Cys Ser His Leu Xaa Asn Phe Ala Ile Leu Met Ala His Arg Glu Ile 
    690                 695                 700                 


Ala Tyr Lys Asp Gly Val His Glu Leu Leu Leu Xaa Val Ile Xaa Trp 
705                 710                 715                 720 


Val Gly Ile Val Ile Ser Leu Val Cys Leu Ala Ile Cys Ile Phe Xaa 
                725                 730                 735     


Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn Xaa Ile His Lys 
            740                 745                 750         


Asn Leu Cys Ile Asn Leu Phe Ile Ala Glu Phe Ile Phe Leu Ile Gly 
        755                 760                 765             


Ile Asp Lys Xaa Lys Tyr Ala Ile Ala Cys Pro Ile Phe Ala Gly Leu 
    770                 775                 780                 


Leu His Phe Phe Phe Leu Ala Ala Phe Ala Trp Met Cys Leu Glu Gly 
785                 790                 795                 800 


Val Gln Leu Tyr Leu Met Leu Val Glu Val Phe Glu Ser Glu Tyr Ser 
                805                 810                 815     


Arg Lys Lys Tyr Tyr Tyr Val Ala Gly Tyr Leu Phe Pro Ala Xaa Val 
            820                 825                 830         


Val Gly Val Ser Ala Ala Ile Asp Tyr Lys Ser Tyr Gly Xaa Glu Lys 
        835                 840                 845             


Ala Cys Trp Leu His Val Asp Asn Tyr Phe Ile Trp Ser Phe Ile Gly 
    850                 855                 860                 


Pro Val Xaa Phe Ile Ile Leu Leu Asn Ile Ile Phe Leu Val Ile Xaa 
865                 870                 875                 880 


Leu Cys Lys Met Val Lys His Ser Asn Xaa Leu Lys Pro Asp Ser Ser 
                885                 890                 895     


Arg Leu Glu Asn Ile Asn Asn Tyr Arg Val Cys Asp Gly Tyr Tyr Asn 
            900                 905                 910         


Xaa Asp Leu Pro Gly Tyr Glu Asp Asn Lys Pro Phe Ile Lys Ser Trp 
        915                 920                 925             


Val Leu Gly Ala Phe Ala Leu Leu Cys Leu Leu Gly Leu Xaa Trp Ser 
    930                 935                 940                 


Phe Gly Leu Leu Phe Ile Asn Glu Glu Xaa Ile Val Met Ala Tyr Leu 
945                 950                 955                 960 


Phe Xaa Ile Phe Asn Ala Phe Gln Gly Val Phe Ile Phe Ile Phe His 
                965                 970                 975     


Cys Ala Leu Gln Lys Lys Val Arg Lys Glu Tyr Gly Lys Cys Phe Arg 
            980                 985                 990         


His Ser Tyr Cys Cys Gly Gly Leu  Pro Xaa Glu Ser Pro  His Ser Ser 
        995                 1000                 1005             


Val Lys  Ala Ser Xaa Xaa Arg  Xaa Ser Ala Arg Tyr  Ser Ser Gly 
    1010                 1015                 1020             


Xaa Gln  Ser Arg Ile Arg Arg  Met Trp Asn Asp Xaa  Val Arg Lys 
    1025                 1030                 1035             


Gln Ser  Glu Ser Ser Phe Ile  Ser Gly Asp Ile Asn  Ser Xaa Ser 
    1040                 1045                 1050             


Xaa Leu  Asn Gln Gly Met Xaa  Gly Asn Tyr Leu Leu  Xaa Asn Pro 
    1055                 1060                 1065             


Leu Leu  Arg Pro His Gly Xaa  Asn Asn Pro Tyr Asn  Xaa Leu Leu 
    1070                 1075                 1080             


Ala Glu  Xaa Val Val Cys Asn  Ala Pro Ser Ala Pro  Val Phe Asn 
    1085                 1090                 1095             


Ser Pro  Gly His Ser Leu Asn  Asn Ala Arg Asp Xaa  Ser Ala Met 
    1100                 1105                 1110             


Asp Xaa  Leu Pro Leu Asn Gly  Asn Phe Asn Asn Ser  Tyr Ser Leu 
    1115                 1120                 1125             


His Lys  Gly Asp Tyr Asn Asp  Ser Val Gln Val Val  Asp Cys Gly 
    1130                 1135                 1140             


Leu Ser  Leu Asn Asp Xaa Ala  Phe Glu Lys Met Ile  Ile Ser Glu 
    1145                 1150                 1155             


Leu Val  His Asn Asn Leu Arg  Gly Ser Ser Lys Xaa  His Asn Leu 
    1160                 1165                 1170             


Glu Leu  Xaa Leu Pro Val Lys  Pro Val Ile Gly Gly  Ser Ser Ser 
    1175                 1180                 1185             


Glu Asp  Asp Ala Ile Val Ala  Asp Ala Ser Ser Leu  Met His Ser 
    1190                 1195                 1200             


Asp Asn  Pro Gly Leu Glu Leu  His His Lys Glu Leu  Glu Ala Pro 
    1205                 1210                 1215             


Leu Ile  Pro Gln Arg Xaa His  Ser Leu Leu Tyr Gln  Pro Gln Lys 
    1220                 1225                 1230             


Lys Val  Lys Ser Glu Gly Xaa  Asp Ser Tyr Val Ser  Gln Leu Xaa 
    1235                 1240                 1245             


Ala Glu  Ala Glu Asp His Leu  Gln Ser Pro Asn Arg  Asp Ser Leu 
    1250                 1255                 1260             


Tyr Xaa  Ser Met Pro Asn Leu  Arg Asp Ser Pro Tyr  Pro Glu Ser 
    1265                 1270                 1275             


Ser Pro  Asp Met Glu Glu Asp  Leu Ser Pro Ser Arg  Arg Ser Glu 
    1280                 1285                 1290             


Asn Glu  Asp Ile Tyr Tyr Lys  Ser Met Pro Asn Leu  Gly Ala Gly 
    1295                 1300                 1305             


His Gln  Leu Gln Met Cys Tyr  Gln Ile Ser Arg Gly  Asn Ser Asp 
    1310                 1315                 1320             


Gly Tyr  Ile Ile Pro Ile Asn  Lys Glu Gly Cys Ile  Pro Glu Gly 
    1325                 1330                 1335             


Asp Val  Arg Glu Gly Gln Met  Gln Leu Val Xaa Ser  Leu 
    1340                 1345                 1350     


<210> 1771
<211> 471
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<400> 1771
Xaa Ile Xaa Leu Cys Lys Met Val Lys His Ser Asn Xaa Leu Lys Pro 
1               5                   10                  15      


Asp Ser Ser Arg Leu Glu Asn Ile Asn Asn Tyr Arg Val Cys Asp Gly 
            20                  25                  30          


Tyr Tyr Asn Xaa Asp Leu Pro Gly Ser Trp Val Leu Gly Ala Phe Ala 
        35                  40                  45              


Leu Leu Cys Leu Leu Gly Leu Xaa Trp Ser Phe Gly Leu Leu Phe Ile 
    50                  55                  60                  


Asn Glu Glu Xaa Ile Val Met Ala Tyr Leu Phe Xaa Ile Phe Asn Ala 
65                  70                  75                  80  


Phe Gln Gly Val Phe Ile Phe Ile Phe His Cys Ala Leu Gln Lys Lys 
                85                  90                  95      


Val Arg Lys Glu Tyr Gly Lys Cys Phe Arg His Ser Tyr Cys Cys Gly 
            100                 105                 110         


Gly Leu Pro Xaa Glu Ser Pro His Ser Ser Val Lys Ala Ser Xaa Xaa 
        115                 120                 125             


Arg Xaa Ser Ala Arg Tyr Ser Ser Gly Xaa Gln Ser Arg Ile Arg Arg 
    130                 135                 140                 


Met Trp Asn Asp Xaa Val Arg Lys Gln Ser Glu Ser Ser Phe Ile Ser 
145                 150                 155                 160 


Gly Asp Ile Asn Ser Xaa Ser Xaa Leu Asn Gln Gly Met Xaa Gly Asn 
                165                 170                 175     


Tyr Leu Leu Xaa Asn Pro Leu Leu Arg Pro His Gly Xaa Asn Asn Pro 
            180                 185                 190         


Tyr Asn Xaa Leu Leu Ala Glu Xaa Val Val Cys Asn Ala Pro Ser Ala 
        195                 200                 205             


Pro Val Phe Asn Ser Pro Ala Xaa Tyr Arg Glu Xaa Arg His Ser Leu 
    210                 215                 220                 


Asn Asn Ala Arg Asp Xaa Ser Ala Met Asp Xaa Leu Pro Leu Asn Gly 
225                 230                 235                 240 


Asn Phe Asn Asn Ser Tyr Ser Leu His Lys Gly Asp Tyr Asn Asp Ser 
                245                 250                 255     


Val Gln Val Val Asp Cys Gly Leu Ser Leu Asn Asp Xaa Ala Phe Glu 
            260                 265                 270         


Lys Met Ile Ile Ser Glu Leu Val His Asn Asn Leu Arg Gly Ser Ser 
        275                 280                 285             


Lys Xaa His Asn Leu Glu Leu Xaa Leu Pro Val Lys Pro Val Ile Gly 
    290                 295                 300                 


Gly Ser Ser Ser Glu Asp Asp Ala Ile Val Ala Asp Ala Ser Ser Leu 
305                 310                 315                 320 


Met His Ser Asp Asn Pro Gly Leu Glu Leu His His Lys Glu Leu Glu 
                325                 330                 335     


Ala Pro Leu Ile Pro Gln Arg Xaa His Ser Leu Leu Tyr Gln Pro Gln 
            340                 345                 350         


Lys Lys Val Lys Ser Glu Gly Xaa Asp Ser Tyr Val Ser Gln Leu Xaa 
        355                 360                 365             


Ala Glu Ala Glu Asp His Leu Gln Ser Pro Asn Arg Asp Ser Leu Tyr 
    370                 375                 380                 


Xaa Ser Met Pro Asn Leu Arg Asp Ser Pro Tyr Pro Glu Ser Ser Pro 
385                 390                 395                 400 


Asp Met Glu Glu Asp Leu Ser Pro Ser Arg Arg Ser Glu Asn Glu Asp 
                405                 410                 415     


Ile Tyr Tyr Lys Ser Met Pro Asn Leu Gly Ala Gly His Gln Leu Gln 
            420                 425                 430         


Met Cys Tyr Gln Ile Ser Arg Gly Asn Ser Asp Gly Tyr Ile Ile Pro 
        435                 440                 445             


Ile Asn Lys Glu Gly Cys Ile Pro Glu Gly Asp Val Arg Glu Gly Gln 
    450                 455                 460                 


Met Gln Leu Val Xaa Ser Leu 
465                 470     


<210> 1772
<211> 1231
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1131)..(1131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1200)..(1200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1229)
<223> Selenocysteine

<400> 1772
Met Trp Pro Ser Gln Leu Leu Ile Phe Met Met Leu Leu Ala Pro Ile 
1               5                   10                  15      


Ile His Ala Phe Ser Arg Ala Pro Ile Pro Met Ala Val Val Arg Arg 
            20                  25                  30          


Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg Cys Pro Gly Xaa 
        35                  40                  45              


Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg Xaa Asp Asp Lys 
    50                  55                  60                  


Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile Arg Cys Tyr Leu 
65                  70                  75                  80  


Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn Asn Arg Xaa Gln 
                85                  90                  95      


Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp Pro Cys Pro Gly 
            100                 105                 110         


Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val Pro Tyr Lys Val 
        115                 120                 125             


Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys Gly Val Tyr Gln 
    130                 135                 140                 


Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly Ala Trp Cys Lys 
145                 150                 155                 160 


Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met Pro Trp Xaa Pro 
                165                 170                 175     


Tyr Arg Xaa Asp Xaa Leu Xaa Glu Tyr Ser Ser Lys Asp Asp Phe Ile 
            180                 185                 190         


Ala Gly Arg Pro Xaa Xaa Xaa Tyr Lys Leu Pro His Arg Val Asp Gly 
        195                 200                 205             


Xaa Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe Asn Lys Glu Arg 
    210                 215                 220                 


Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg Ile Lys Ser Gly 
225                 230                 235                 240 


Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Xaa Ser Pro Tyr Arg 
                245                 250                 255     


Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp Glu Asn Gly Leu 
            260                 265                 270         


Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Lys Ile Val Ile Ser 
        275                 280                 285             


Gln Leu Asn Pro Tyr Xaa Leu Arg Ile Glu Gly Xaa Trp Asp Xaa Ala 
    290                 295                 300                 


Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile Cys Gly Ile Leu 
305                 310                 315                 320 


Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn Glu Ala Xaa Gly 
                325                 330                 335     


Asn Lys Ile Asp Tyr Ile Tyr Asn Xaa Asp Gln Ser Lys Asp Ser Leu 
            340                 345                 350         


Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile Ala Ala Val Asp 
        355                 360                 365             


Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn Asn Tyr His Val 
    370                 375                 380                 


Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser Arg Ser Gly Gln 
385                 390                 395                 400 


Ala His His Gly Gln Val Ser Tyr Ile Ser Pro Pro Ile His Leu Asp 
                405                 410                 415     


Ser Glu Leu Glu Arg Pro Ser Val Lys Asp Ile Ser Xaa Xaa Gly Pro 
            420                 425                 430         


Leu Gly Met Gly Ser Xaa Xaa Xaa Ser Xaa Xaa Leu Arg Xaa Xaa Xaa 
        435                 440                 445             


Leu Ser Pro Gly Arg Ser Xaa Xaa Pro Ser Val Ser Gly Arg Arg Asn 
    450                 455                 460                 


Arg Ser Xaa Ser Xaa Pro Ser Pro Ala Val Glu Val Leu Asp Asp Met 
465                 470                 475                 480 


Xaa Xaa His Leu Pro Ser Ala Ser Ser Gln Ile Pro Ala Leu Glu Glu 
                485                 490                 495     


Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp Phe Lys Xaa Arg 
            500                 505                 510         


Gln Gly Gln Ile Ala Lys Gln Pro Cys Pro Ala Gly Xaa Ile Gly Val 
        515                 520                 525             


Ser Xaa Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp Asp Pro Gln Gly 
    530                 535                 540                 


Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn His Ile Xaa Gln 
545                 550                 555                 560 


Lys Leu Lys Ser Gly Glu Xaa Ala Ala Asn Ile Ala Arg Glu Leu Ala 
                565                 570                 575     


Glu Gln Xaa Arg Asn His Leu Asn Ala Gly Asp Ile Xaa Tyr Ser Val 
            580                 585                 590         


Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val Gln Leu Arg Asn 
        595                 600                 605             


Leu Xaa Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser Leu Asn Lys Leu 
    610                 615                 620                 


Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln Ala Met Val Glu 
625                 630                 635                 640 


Xaa Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn Ala Trp Arg Asp 
                645                 650                 655     


Leu Xaa Xaa Ser Asp Gln Leu Arg Ala Ala Xaa Met Leu Leu His Xaa 
            660                 665                 670         


Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu Leu Lys Xaa Asp 
        675                 680                 685             


Ile Val Arg Glu Asn Xaa Asp Asn Ile Lys Leu Glu Val Ala Arg Leu 
    690                 695                 700                 


Ser Xaa Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro Glu Asn Met Gly 
705                 710                 715                 720 


His Gly Ser Xaa Ile Gln Leu Ser Ala Asn Xaa Leu Lys Gln Asn Gly 
                725                 730                 735     


Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr Asn Asn Leu Gly 
            740                 745                 750         


Pro Tyr Leu Ser Xaa Glu Asn Ala Ser Met Lys Leu Gly Xaa Glu Ala 
        755                 760                 765             


Leu Ser Xaa Asn His Ser Val Ile Val Asn Ser Pro Val Ile Xaa Ala 
    770                 775                 780                 


Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu Ala Asp Pro Val 
785                 790                 795                 800 


Val Phe Xaa Val Lys His Ile Lys Gln Ser Glu Glu Asn Phe Asn Pro 
                805                 810                 815     


Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Xaa Met Xaa Gly Tyr Trp 
            820                 825                 830         


Ser Xaa Gln Gly Cys Arg Leu Leu Xaa Xaa Asn Lys Xaa His Xaa Xaa 
        835                 840                 845             


Cys Ser Cys Asn His Leu Xaa Asn Phe Ala Val Leu Met Ala His Val 
    850                 855                 860                 


Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu Leu Asp Val Ile 
865                 870                 875                 880 


Xaa Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu Leu Ile Cys Ile 
                885                 890                 895     


Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn Xaa Ile 
            900                 905                 910         


His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu Leu Leu Phe Leu 
        915                 920                 925             


Ile Gly Ile Asn Arg Xaa Asp Gln Pro Ile Ala Cys Ala Val Phe Ala 
    930                 935                 940                 


Ala Leu Leu His Phe Phe Phe Leu Ala Ala Phe Xaa Trp Met Phe Leu 
945                 950                 955                 960 


Glu Gly Val Gln Leu Tyr Ile Met Leu Val Glu Val Phe Glu Ser Glu 
                965                 970                 975     


His Ser Arg Arg Lys Tyr Phe Tyr Leu Val Gly Tyr Gly Met Pro Ala 
            980                 985                 990         


Leu Ile Val Ala Val Ser Ala Ala  Val Asp Tyr Arg Ser  Tyr Gly Xaa 
        995                 1000                 1005             


Asp Lys  Val Cys Trp Leu Arg  Leu Asp Xaa Tyr Phe  Ile Trp Ser 
    1010                 1015                 1020             


Phe Ile  Gly Pro Ala Xaa Leu  Ile Ile Met Leu Asn  Val Ile Phe 
    1025                 1030                 1035             


Leu Gly  Ile Ala Leu Tyr Lys  Met Phe His His Xaa  Ala Ile Leu 
    1040                 1045                 1050             


Lys Pro  Glu Ser Gly Cys Leu  Asp Asn Ile Lys Ser  Trp Val Ile 
    1055                 1060                 1065             


Gly Ala  Ile Ala Leu Leu Cys  Leu Leu Gly Leu Xaa  Trp Ala Phe 
    1070                 1075                 1080             


Gly Leu  Met Tyr Ile Asn Glu  Ser Xaa Val Ile Met  Ala Tyr Leu 
    1085                 1090                 1095             


Phe Xaa  Ile Phe Asn Ser Leu  Gln Gly Met Phe Ile  Phe Ile Phe 
    1100                 1105                 1110             


His Cys  Val Leu Gln Lys Lys  Val Arg Lys Glu Tyr  Gly Lys Cys 
    1115                 1120                 1125             


Leu Arg  Xaa His Cys Cys Ser  Gly Lys Ser Xaa Glu  Ser Ser Ile 
    1130                 1135                 1140             


Gly Ser  Gly Lys Xaa Ser Gly  Ser Arg Xaa Pro Gly  Arg Tyr Ser 
    1145                 1150                 1155             


Xaa Gly  Ser Gln Ser Arg Ile  Arg Arg Met Trp Asn  Asp Xaa Val 
    1160                 1165                 1170             


Arg Lys  Gln Ser Glu Ser Ser  Phe Ile Xaa Gly Asp  Ile Asn Ser 
    1175                 1180                 1185             


Ser Ala  Ser Leu Asn Arg Glu  Pro Tyr Arg Glu Xaa  Ser Met Gly 
    1190                 1195                 1200             


Val Lys  Leu Asn Ile Ala Tyr  Gln Ile Gly Ala Ser  Glu Gln Cys 
    1205                 1210                 1215             


Gln Gly  Tyr Lys Cys His Gly  Tyr Ser Xaa Xaa Glu  Trp 
    1220                 1225                 1230     


<210> 1773
<211> 1240
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1237)..(1238)
<223> Selenocysteine

<400> 1773
Met Trp Pro Ser Gln Leu Leu Ile Phe Met Met Leu Leu Ala Pro Ile 
1               5                   10                  15      


Ile His Ala Phe Ser Arg Ala Pro Ile Pro Met Ala Val Val Arg Arg 
            20                  25                  30          


Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg Cys Pro Gly Xaa 
        35                  40                  45              


Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg Xaa Asp Asp Lys 
    50                  55                  60                  


Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile Arg Cys Tyr Leu 
65                  70                  75                  80  


Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn Asn Arg Xaa Gln 
                85                  90                  95      


Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp Pro Cys Pro Gly 
            100                 105                 110         


Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val Pro Tyr Lys Val 
        115                 120                 125             


Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys Gly Val Tyr Gln 
    130                 135                 140                 


Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly Ala Trp Cys Lys 
145                 150                 155                 160 


Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met Pro Trp Xaa Pro 
                165                 170                 175     


Tyr Arg Xaa Asp Xaa Leu Xaa Glu Tyr Ser Ser Lys Asp Asp Phe Ile 
            180                 185                 190         


Ala Gly Arg Pro Xaa Xaa Xaa Tyr Lys Leu Pro His Arg Val Asp Gly 
        195                 200                 205             


Xaa Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe Asn Lys Glu Arg 
    210                 215                 220                 


Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg Ile Lys Ser Gly 
225                 230                 235                 240 


Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Xaa Ser Pro Tyr Arg 
                245                 250                 255     


Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp Glu Asn Gly Leu 
            260                 265                 270         


Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Lys Ile Val Ile Ser 
        275                 280                 285             


Gln Leu Asn Pro Tyr Xaa Leu Arg Ile Glu Gly Xaa Trp Asp Xaa Ala 
    290                 295                 300                 


Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile Cys Gly Ile Leu 
305                 310                 315                 320 


Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn Glu Ala Xaa Gly 
                325                 330                 335     


Asn Lys Ile Asp Tyr Ile Tyr Asn Xaa Asp Gln Ser Lys Asp Ser Leu 
            340                 345                 350         


Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile Ala Ala Val Asp 
        355                 360                 365             


Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn Asn Tyr His Val 
    370                 375                 380                 


Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser Arg Ser Gly Gln 
385                 390                 395                 400 


Ala His His Gly Gln Val Ser Tyr Ile Ser Pro Pro Ile His Leu Asp 
                405                 410                 415     


Ser Glu Leu Glu Arg Pro Ser Val Lys Asp Ile Ser Xaa Xaa Gly Pro 
            420                 425                 430         


Leu Gly Met Gly Ser Xaa Xaa Xaa Ser Xaa Xaa Leu Arg Xaa Xaa Xaa 
        435                 440                 445             


Leu Ser Pro Gly Arg Ser Xaa Xaa Pro Ser Val Ser Gly Arg Arg Asn 
    450                 455                 460                 


Arg Ser Xaa Ser Xaa Pro Ser Pro Ala Val Glu Val Leu Asp Asp Met 
465                 470                 475                 480 


Xaa Xaa His Leu Pro Ser Ala Ser Ser Gln Ile Pro Ala Leu Glu Glu 
                485                 490                 495     


Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp Phe Lys Xaa Arg 
            500                 505                 510         


Gln Gly Gln Ile Ala Lys Gln Pro Cys Pro Ala Gly Xaa Ile Gly Val 
        515                 520                 525             


Ser Xaa Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp Asp Pro Gln Gly 
    530                 535                 540                 


Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn His Ile Xaa Gln 
545                 550                 555                 560 


Lys Leu Lys Ser Gly Glu Xaa Ala Ala Asn Ile Ala Arg Glu Leu Ala 
                565                 570                 575     


Glu Gln Xaa Arg Asn His Leu Asn Ala Gly Asp Ile Xaa Tyr Ser Val 
            580                 585                 590         


Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val Gln Leu Arg Asn 
        595                 600                 605             


Leu Xaa Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser Leu Asn Lys Leu 
    610                 615                 620                 


Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln Ala Met Val Glu 
625                 630                 635                 640 


Xaa Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn Ala Trp Arg Asp 
                645                 650                 655     


Leu Xaa Xaa Ser Asp Gln Leu Arg Ala Ala Xaa Met Leu Leu His Xaa 
            660                 665                 670         


Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu Leu Lys Xaa Asp 
        675                 680                 685             


Ile Val Arg Glu Asn Xaa Asp Asn Ile Lys Leu Glu Val Ala Arg Leu 
    690                 695                 700                 


Ser Xaa Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro Glu Asn Met Gly 
705                 710                 715                 720 


His Gly Ser Xaa Ile Gln Leu Ser Ala Asn Xaa Leu Lys Gln Asn Gly 
                725                 730                 735     


Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr Asn Asn Leu Gly 
            740                 745                 750         


Pro Tyr Leu Ser Xaa Glu Asn Ala Ser Met Lys Leu Gly Xaa Glu Ala 
        755                 760                 765             


Leu Ser Xaa Asn His Ser Val Ile Val Asn Ser Pro Val Ile Xaa Ala 
    770                 775                 780                 


Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu Ala Asp Pro Val 
785                 790                 795                 800 


Val Phe Xaa Val Lys His Ile Lys Gln Ser Glu Glu Asn Phe Asn Pro 
                805                 810                 815     


Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Xaa Met Xaa Gly Tyr Trp 
            820                 825                 830         


Ser Xaa Gln Gly Cys Arg Leu Leu Xaa Xaa Asn Lys Xaa His Xaa Xaa 
        835                 840                 845             


Cys Ser Cys Asn His Leu Xaa Asn Phe Ala Val Leu Met Ala His Val 
    850                 855                 860                 


Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu Leu Asp Val Ile 
865                 870                 875                 880 


Xaa Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu Leu Ile Cys Ile 
                885                 890                 895     


Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn Xaa Ile 
            900                 905                 910         


His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu Leu Leu Phe Leu 
        915                 920                 925             


Ile Gly Ile Asn Arg Xaa Asp Gln Pro Ile Ala Cys Ala Val Phe Ala 
    930                 935                 940                 


Ala Leu Leu His Phe Phe Phe Leu Ala Ala Phe Xaa Trp Met Phe Leu 
945                 950                 955                 960 


Glu Gly Val Gln Leu Tyr Ile Met Leu Val Glu Val Phe Glu Ser Glu 
                965                 970                 975     


His Ser Arg Arg Lys Tyr Phe Tyr Leu Val Gly Tyr Gly Met Pro Ala 
            980                 985                 990         


Leu Ile Val Ala Val Ser Ala Ala  Val Asp Tyr Arg Ser  Tyr Gly Xaa 
        995                 1000                 1005             


Asp Lys  Val Cys Trp Leu Arg  Leu Asp Xaa Tyr Phe  Ile Trp Ser 
    1010                 1015                 1020             


Phe Ile  Gly Pro Ala Xaa Leu  Ile Ile Met Leu Asn  Val Ile Phe 
    1025                 1030                 1035             


Leu Gly  Ile Ala Leu Tyr Lys  Met Phe His His Xaa  Ala Ile Leu 
    1040                 1045                 1050             


Lys Pro  Glu Ser Gly Cys Leu  Asp Asn Ile Asn Tyr  Glu Asp Asn 
    1055                 1060                 1065             


Arg Pro  Phe Ile Lys Ser Trp  Val Ile Gly Ala Ile  Ala Leu Leu 
    1070                 1075                 1080             


Cys Leu  Leu Gly Leu Xaa Trp  Ala Phe Gly Leu Met  Tyr Ile Asn 
    1085                 1090                 1095             


Glu Ser  Xaa Val Ile Met Ala  Tyr Leu Phe Xaa Ile  Phe Asn Ser 
    1100                 1105                 1110             


Leu Gln  Gly Met Phe Ile Phe  Ile Phe His Cys Val  Leu Gln Lys 
    1115                 1120                 1125             


Lys Val  Arg Lys Glu Tyr Gly  Lys Cys Leu Arg Xaa  His Cys Cys 
    1130                 1135                 1140             


Ser Gly  Lys Ser Xaa Glu Ser  Ser Ile Gly Ser Gly  Lys Xaa Ser 
    1145                 1150                 1155             


Gly Ser  Arg Xaa Pro Gly Arg  Tyr Ser Xaa Gly Ser  Gln Ser Arg 
    1160                 1165                 1170             


Ile Arg  Arg Met Trp Asn Asp  Xaa Val Arg Lys Gln  Ser Glu Ser 
    1175                 1180                 1185             


Ser Phe  Ile Xaa Gly Asp Ile  Asn Ser Ser Ala Ser  Leu Asn Arg 
    1190                 1195                 1200             


Glu Pro  Tyr Arg Glu Xaa Ser  Met Gly Val Lys Leu  Asn Ile Ala 
    1205                 1210                 1215             


Tyr Gln  Ile Gly Ala Ser Glu  Gln Cys Gln Gly Tyr  Lys Cys His 
    1220                 1225                 1230             


Gly Tyr  Ser Xaa Xaa Glu Trp  
    1235                 1240 


<210> 1774
<211> 1274
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1131)..(1131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1218)..(1218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1243)..(1243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1272)
<223> Selenocysteine

<400> 1774
Met Trp Pro Ser Gln Leu Leu Ile Phe Met Met Leu Leu Ala Pro Ile 
1               5                   10                  15      


Ile His Ala Phe Ser Arg Ala Pro Ile Pro Met Ala Val Val Arg Arg 
            20                  25                  30          


Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg Cys Pro Gly Xaa 
        35                  40                  45              


Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg Xaa Asp Asp Lys 
    50                  55                  60                  


Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile Arg Cys Tyr Leu 
65                  70                  75                  80  


Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn Asn Arg Xaa Gln 
                85                  90                  95      


Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp Pro Cys Pro Gly 
            100                 105                 110         


Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val Pro Tyr Lys Val 
        115                 120                 125             


Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys Gly Val Tyr Gln 
    130                 135                 140                 


Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly Ala Trp Cys Lys 
145                 150                 155                 160 


Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met Pro Trp Xaa Pro 
                165                 170                 175     


Tyr Arg Xaa Asp Xaa Leu Xaa Glu Tyr Ser Ser Lys Asp Asp Phe Ile 
            180                 185                 190         


Ala Gly Arg Pro Xaa Xaa Xaa Tyr Lys Leu Pro His Arg Val Asp Gly 
        195                 200                 205             


Xaa Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe Asn Lys Glu Arg 
    210                 215                 220                 


Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg Ile Lys Ser Gly 
225                 230                 235                 240 


Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Xaa Ser Pro Tyr Arg 
                245                 250                 255     


Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp Glu Asn Gly Leu 
            260                 265                 270         


Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Lys Ile Val Ile Ser 
        275                 280                 285             


Gln Leu Asn Pro Tyr Xaa Leu Arg Ile Glu Gly Xaa Trp Asp Xaa Ala 
    290                 295                 300                 


Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile Cys Gly Ile Leu 
305                 310                 315                 320 


Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn Glu Ala Xaa Gly 
                325                 330                 335     


Asn Lys Ile Asp Tyr Ile Tyr Asn Xaa Asp Gln Ser Lys Asp Ser Leu 
            340                 345                 350         


Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile Ala Ala Val Asp 
        355                 360                 365             


Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn Asn Tyr His Val 
    370                 375                 380                 


Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser Arg Ser Gly Gln 
385                 390                 395                 400 


Ala His His Gly Gln Val Ser Tyr Ile Ser Pro Pro Ile His Leu Asp 
                405                 410                 415     


Ser Glu Leu Glu Arg Pro Ser Val Lys Asp Ile Ser Xaa Xaa Gly Pro 
            420                 425                 430         


Leu Gly Met Gly Ser Xaa Xaa Xaa Ser Xaa Xaa Leu Arg Xaa Xaa Xaa 
        435                 440                 445             


Leu Ser Pro Gly Arg Ser Xaa Xaa Pro Ser Val Ser Gly Arg Arg Asn 
    450                 455                 460                 


Arg Ser Xaa Ser Xaa Pro Ser Pro Ala Val Glu Val Leu Asp Asp Met 
465                 470                 475                 480 


Xaa Xaa His Leu Pro Ser Ala Ser Ser Gln Ile Pro Ala Leu Glu Glu 
                485                 490                 495     


Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp Phe Lys Xaa Arg 
            500                 505                 510         


Gln Gly Gln Ile Ala Lys Gln Pro Cys Pro Ala Gly Xaa Ile Gly Val 
        515                 520                 525             


Ser Xaa Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp Asp Pro Gln Gly 
    530                 535                 540                 


Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn His Ile Xaa Gln 
545                 550                 555                 560 


Lys Leu Lys Ser Gly Glu Xaa Ala Ala Asn Ile Ala Arg Glu Leu Ala 
                565                 570                 575     


Glu Gln Xaa Arg Asn His Leu Asn Ala Gly Asp Ile Xaa Tyr Ser Val 
            580                 585                 590         


Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val Gln Leu Arg Asn 
        595                 600                 605             


Leu Xaa Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser Leu Asn Lys Leu 
    610                 615                 620                 


Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln Ala Met Val Glu 
625                 630                 635                 640 


Xaa Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn Ala Trp Arg Asp 
                645                 650                 655     


Leu Xaa Xaa Ser Asp Gln Leu Arg Ala Ala Xaa Met Leu Leu His Xaa 
            660                 665                 670         


Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu Leu Lys Xaa Asp 
        675                 680                 685             


Ile Val Arg Glu Asn Xaa Asp Asn Ile Lys Leu Glu Val Ala Arg Leu 
    690                 695                 700                 


Ser Xaa Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro Glu Asn Met Gly 
705                 710                 715                 720 


His Gly Ser Xaa Ile Gln Leu Ser Ala Asn Xaa Leu Lys Gln Asn Gly 
                725                 730                 735     


Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr Asn Asn Leu Gly 
            740                 745                 750         


Pro Tyr Leu Ser Xaa Glu Asn Ala Ser Met Lys Leu Gly Xaa Glu Ala 
        755                 760                 765             


Leu Ser Xaa Asn His Ser Val Ile Val Asn Ser Pro Val Ile Xaa Ala 
    770                 775                 780                 


Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu Ala Asp Pro Val 
785                 790                 795                 800 


Val Phe Xaa Val Lys His Ile Lys Gln Ser Glu Glu Asn Phe Asn Pro 
                805                 810                 815     


Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Xaa Met Xaa Gly Tyr Trp 
            820                 825                 830         


Ser Xaa Gln Gly Cys Arg Leu Leu Xaa Xaa Asn Lys Xaa His Xaa Xaa 
        835                 840                 845             


Cys Ser Cys Asn His Leu Xaa Asn Phe Ala Val Leu Met Ala His Val 
    850                 855                 860                 


Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu Leu Asp Val Ile 
865                 870                 875                 880 


Xaa Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu Leu Ile Cys Ile 
                885                 890                 895     


Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn Xaa Ile 
            900                 905                 910         


His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu Leu Leu Phe Leu 
        915                 920                 925             


Ile Gly Ile Asn Arg Xaa Asp Gln Pro Ile Ala Cys Ala Val Phe Ala 
    930                 935                 940                 


Ala Leu Leu His Phe Phe Phe Leu Ala Ala Phe Xaa Trp Met Phe Leu 
945                 950                 955                 960 


Glu Gly Val Gln Leu Tyr Ile Met Leu Val Glu Val Phe Glu Ser Glu 
                965                 970                 975     


His Ser Arg Arg Lys Tyr Phe Tyr Leu Val Gly Tyr Gly Met Pro Ala 
            980                 985                 990         


Leu Ile Val Ala Val Ser Ala Ala  Val Asp Tyr Arg Ser  Tyr Gly Xaa 
        995                 1000                 1005             


Asp Lys  Val Cys Trp Leu Arg  Leu Asp Xaa Tyr Phe  Ile Trp Ser 
    1010                 1015                 1020             


Phe Ile  Gly Pro Ala Xaa Leu  Ile Ile Met Leu Asn  Val Ile Phe 
    1025                 1030                 1035             


Leu Gly  Ile Ala Leu Tyr Lys  Met Phe His His Xaa  Ala Ile Leu 
    1040                 1045                 1050             


Lys Pro  Glu Ser Gly Cys Leu  Asp Asn Ile Lys Ser  Trp Val Ile 
    1055                 1060                 1065             


Gly Ala  Ile Ala Leu Leu Cys  Leu Leu Gly Leu Xaa  Trp Ala Phe 
    1070                 1075                 1080             


Gly Leu  Met Tyr Ile Asn Glu  Ser Xaa Val Ile Met  Ala Tyr Leu 
    1085                 1090                 1095             


Phe Xaa  Ile Phe Asn Ser Leu  Gln Gly Met Phe Ile  Phe Ile Phe 
    1100                 1105                 1110             


His Cys  Val Leu Gln Lys Lys  Val Arg Lys Glu Tyr  Gly Lys Cys 
    1115                 1120                 1125             


Leu Arg  Xaa His Cys Cys Ser  Gly Lys Ser Xaa Glu  Ser Ser Ile 
    1130                 1135                 1140             


Gly Ser  Gly Lys Xaa Ser Gly  Ser Arg Xaa Pro Gly  Arg Tyr Ser 
    1145                 1150                 1155             


Xaa Gly  Ser Gln Ser Arg Ile  Arg Arg Met Trp Asn  Asp Xaa Val 
    1160                 1165                 1170             


Arg Lys  Gln Ser Glu Ser Ser  Phe Ile Xaa Gly Asp  Ile Asn Ser 
    1175                 1180                 1185             


Ser Ala  Ser Leu Asn Arg Gly  Ala Met Ala Asn His  Leu Ile Ser 
    1190                 1195                 1200             


Asn Ala  Leu Leu Arg Pro His  Gly Xaa Asn Asn Pro  Tyr Asn Xaa 
    1205                 1210                 1215             


Leu Leu  Gly Glu Pro Ala Val  Cys Asn Asn Pro Ser  Val Ser Met 
    1220                 1225                 1230             


Tyr Asn  Ala Gln Glu Pro Tyr  Arg Glu Xaa Ser Met  Gly Val Lys 
    1235                 1240                 1245             


Leu Asn  Ile Ala Tyr Gln Ile  Gly Ala Ser Glu Gln  Cys Gln Gly 
    1250                 1255                 1260             


Tyr Lys  Cys His Gly Tyr Ser  Xaa Xaa Glu Trp 
    1265                 1270                 


<210> 1775
<211> 1283
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1221)..(1221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1252)..(1252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1280)..(1281)
<223> Selenocysteine

<400> 1775
Met Trp Pro Ser Gln Leu Leu Ile Phe Met Met Leu Leu Ala Pro Ile 
1               5                   10                  15      


Ile His Ala Phe Ser Arg Ala Pro Ile Pro Met Ala Val Val Arg Arg 
            20                  25                  30          


Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg Cys Pro Gly Xaa 
        35                  40                  45              


Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg Xaa Asp Asp Lys 
    50                  55                  60                  


Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile Arg Cys Tyr Leu 
65                  70                  75                  80  


Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn Asn Arg Xaa Gln 
                85                  90                  95      


Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp Pro Cys Pro Gly 
            100                 105                 110         


Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val Pro Tyr Lys Val 
        115                 120                 125             


Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys Gly Val Tyr Gln 
    130                 135                 140                 


Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly Ala Trp Cys Lys 
145                 150                 155                 160 


Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met Pro Trp Xaa Pro 
                165                 170                 175     


Tyr Arg Xaa Asp Xaa Leu Xaa Glu Tyr Ser Ser Lys Asp Asp Phe Ile 
            180                 185                 190         


Ala Gly Arg Pro Xaa Xaa Xaa Tyr Lys Leu Pro His Arg Val Asp Gly 
        195                 200                 205             


Xaa Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe Asn Lys Glu Arg 
    210                 215                 220                 


Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg Ile Lys Ser Gly 
225                 230                 235                 240 


Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Xaa Ser Pro Tyr Arg 
                245                 250                 255     


Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp Glu Asn Gly Leu 
            260                 265                 270         


Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Lys Ile Val Ile Ser 
        275                 280                 285             


Gln Leu Asn Pro Tyr Xaa Leu Arg Ile Glu Gly Xaa Trp Asp Xaa Ala 
    290                 295                 300                 


Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile Cys Gly Ile Leu 
305                 310                 315                 320 


Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn Glu Ala Xaa Gly 
                325                 330                 335     


Asn Lys Ile Asp Tyr Ile Tyr Asn Xaa Asp Gln Ser Lys Asp Ser Leu 
            340                 345                 350         


Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile Ala Ala Val Asp 
        355                 360                 365             


Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn Asn Tyr His Val 
    370                 375                 380                 


Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser Arg Ser Gly Gln 
385                 390                 395                 400 


Ala His His Gly Gln Val Ser Tyr Ile Ser Pro Pro Ile His Leu Asp 
                405                 410                 415     


Ser Glu Leu Glu Arg Pro Ser Val Lys Asp Ile Ser Xaa Xaa Gly Pro 
            420                 425                 430         


Leu Gly Met Gly Ser Xaa Xaa Xaa Ser Xaa Xaa Leu Arg Xaa Xaa Xaa 
        435                 440                 445             


Leu Ser Pro Gly Arg Ser Xaa Xaa Pro Ser Val Ser Gly Arg Arg Asn 
    450                 455                 460                 


Arg Ser Xaa Ser Xaa Pro Ser Pro Ala Val Glu Val Leu Asp Asp Met 
465                 470                 475                 480 


Xaa Xaa His Leu Pro Ser Ala Ser Ser Gln Ile Pro Ala Leu Glu Glu 
                485                 490                 495     


Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp Phe Lys Xaa Arg 
            500                 505                 510         


Gln Gly Gln Ile Ala Lys Gln Pro Cys Pro Ala Gly Xaa Ile Gly Val 
        515                 520                 525             


Ser Xaa Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp Asp Pro Gln Gly 
    530                 535                 540                 


Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn His Ile Xaa Gln 
545                 550                 555                 560 


Lys Leu Lys Ser Gly Glu Xaa Ala Ala Asn Ile Ala Arg Glu Leu Ala 
                565                 570                 575     


Glu Gln Xaa Arg Asn His Leu Asn Ala Gly Asp Ile Xaa Tyr Ser Val 
            580                 585                 590         


Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val Gln Leu Arg Asn 
        595                 600                 605             


Leu Xaa Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser Leu Asn Lys Leu 
    610                 615                 620                 


Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln Ala Met Val Glu 
625                 630                 635                 640 


Xaa Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn Ala Trp Arg Asp 
                645                 650                 655     


Leu Xaa Xaa Ser Asp Gln Leu Arg Ala Ala Xaa Met Leu Leu His Xaa 
            660                 665                 670         


Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu Leu Lys Xaa Asp 
        675                 680                 685             


Ile Val Arg Glu Asn Xaa Asp Asn Ile Lys Leu Glu Val Ala Arg Leu 
    690                 695                 700                 


Ser Xaa Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro Glu Asn Met Gly 
705                 710                 715                 720 


His Gly Ser Xaa Ile Gln Leu Ser Ala Asn Xaa Leu Lys Gln Asn Gly 
                725                 730                 735     


Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr Asn Asn Leu Gly 
            740                 745                 750         


Pro Tyr Leu Ser Xaa Glu Asn Ala Ser Met Lys Leu Gly Xaa Glu Ala 
        755                 760                 765             


Leu Ser Xaa Asn His Ser Val Ile Val Asn Ser Pro Val Ile Xaa Ala 
    770                 775                 780                 


Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu Ala Asp Pro Val 
785                 790                 795                 800 


Val Phe Xaa Val Lys His Ile Lys Gln Ser Glu Glu Asn Phe Asn Pro 
                805                 810                 815     


Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Xaa Met Xaa Gly Tyr Trp 
            820                 825                 830         


Ser Xaa Gln Gly Cys Arg Leu Leu Xaa Xaa Asn Lys Xaa His Xaa Xaa 
        835                 840                 845             


Cys Ser Cys Asn His Leu Xaa Asn Phe Ala Val Leu Met Ala His Val 
    850                 855                 860                 


Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu Leu Asp Val Ile 
865                 870                 875                 880 


Xaa Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu Leu Ile Cys Ile 
                885                 890                 895     


Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn Xaa Ile 
            900                 905                 910         


His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu Leu Leu Phe Leu 
        915                 920                 925             


Ile Gly Ile Asn Arg Xaa Asp Gln Pro Ile Ala Cys Ala Val Phe Ala 
    930                 935                 940                 


Ala Leu Leu His Phe Phe Phe Leu Ala Ala Phe Xaa Trp Met Phe Leu 
945                 950                 955                 960 


Glu Gly Val Gln Leu Tyr Ile Met Leu Val Glu Val Phe Glu Ser Glu 
                965                 970                 975     


His Ser Arg Arg Lys Tyr Phe Tyr Leu Val Gly Tyr Gly Met Pro Ala 
            980                 985                 990         


Leu Ile Val Ala Val Ser Ala Ala  Val Asp Tyr Arg Ser  Tyr Gly Xaa 
        995                 1000                 1005             


Asp Lys  Val Cys Trp Leu Arg  Leu Asp Xaa Tyr Phe  Ile Trp Ser 
    1010                 1015                 1020             


Phe Ile  Gly Pro Ala Xaa Leu  Ile Ile Met Leu Asn  Val Ile Phe 
    1025                 1030                 1035             


Leu Gly  Ile Ala Leu Tyr Lys  Met Phe His His Xaa  Ala Ile Leu 
    1040                 1045                 1050             


Lys Pro  Glu Ser Gly Cys Leu  Asp Asn Ile Asn Tyr  Glu Asp Asn 
    1055                 1060                 1065             


Arg Pro  Phe Ile Lys Ser Trp  Val Ile Gly Ala Ile  Ala Leu Leu 
    1070                 1075                 1080             


Cys Leu  Leu Gly Leu Xaa Trp  Ala Phe Gly Leu Met  Tyr Ile Asn 
    1085                 1090                 1095             


Glu Ser  Xaa Val Ile Met Ala  Tyr Leu Phe Xaa Ile  Phe Asn Ser 
    1100                 1105                 1110             


Leu Gln  Gly Met Phe Ile Phe  Ile Phe His Cys Val  Leu Gln Lys 
    1115                 1120                 1125             


Lys Val  Arg Lys Glu Tyr Gly  Lys Cys Leu Arg Xaa  His Cys Cys 
    1130                 1135                 1140             


Ser Gly  Lys Ser Xaa Glu Ser  Ser Ile Gly Ser Gly  Lys Xaa Ser 
    1145                 1150                 1155             


Gly Ser  Arg Xaa Pro Gly Arg  Tyr Ser Xaa Gly Ser  Gln Ser Arg 
    1160                 1165                 1170             


Ile Arg  Arg Met Trp Asn Asp  Xaa Val Arg Lys Gln  Ser Glu Ser 
    1175                 1180                 1185             


Ser Phe  Ile Xaa Gly Asp Ile  Asn Ser Ser Ala Ser  Leu Asn Arg 
    1190                 1195                 1200             


Gly Ala  Met Ala Asn His Leu  Ile Ser Asn Ala Leu  Leu Arg Pro 
    1205                 1210                 1215             


His Gly  Xaa Asn Asn Pro Tyr  Asn Xaa Leu Leu Gly  Glu Pro Ala 
    1220                 1225                 1230             


Val Cys  Asn Asn Pro Ser Val  Ser Met Tyr Asn Ala  Gln Glu Pro 
    1235                 1240                 1245             


Tyr Arg  Glu Xaa Ser Met Gly  Val Lys Leu Asn Ile  Ala Tyr Gln 
    1250                 1255                 1260             


Ile Gly  Ala Ser Glu Gln Cys  Gln Gly Tyr Lys Cys  His Gly Tyr 
    1265                 1270                 1275             


Ser Xaa  Xaa Glu Trp 
    1280             


<210> 1776
<211> 1469
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1213)..(1213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1218)..(1218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1253)..(1253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1308)..(1308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1346)..(1346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1363)..(1363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1367)..(1367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1380)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1384)..(1384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1391)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1395)..(1396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1398)..(1398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1400)..(1400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1432)..(1432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1453)..(1453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1467)..(1467)
<223> Selenocysteine

<400> 1776
Met Trp Pro Ser Gln Leu Leu Ile Phe Met Met Leu Leu Ala Pro Ile 
1               5                   10                  15      


Ile His Ala Phe Ser Arg Ala Pro Ile Pro Met Ala Val Val Arg Arg 
            20                  25                  30          


Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg Cys Pro Gly Xaa 
        35                  40                  45              


Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg Xaa Asp Asp Lys 
    50                  55                  60                  


Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile Arg Cys Tyr Leu 
65                  70                  75                  80  


Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn Asn Arg Xaa Gln 
                85                  90                  95      


Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp Pro Cys Pro Gly 
            100                 105                 110         


Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val Pro Tyr Lys Val 
        115                 120                 125             


Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys Gly Val Tyr Gln 
    130                 135                 140                 


Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly Ala Trp Cys Lys 
145                 150                 155                 160 


Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met Pro Trp Xaa Pro 
                165                 170                 175     


Tyr Arg Xaa Asp Xaa Leu Xaa Glu Tyr Ser Ser Lys Asp Asp Phe Ile 
            180                 185                 190         


Ala Gly Arg Pro Xaa Xaa Xaa Tyr Lys Leu Pro His Arg Val Asp Gly 
        195                 200                 205             


Xaa Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe Asn Lys Glu Arg 
    210                 215                 220                 


Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg Ile Lys Ser Gly 
225                 230                 235                 240 


Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Xaa Ser Pro Tyr Arg 
                245                 250                 255     


Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp Glu Asn Gly Leu 
            260                 265                 270         


Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Lys Ile Val Ile Ser 
        275                 280                 285             


Gln Leu Asn Pro Tyr Xaa Leu Arg Ile Glu Gly Xaa Trp Asp Xaa Ala 
    290                 295                 300                 


Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile Cys Gly Ile Leu 
305                 310                 315                 320 


Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn Glu Ala Xaa Gly 
                325                 330                 335     


Asn Lys Ile Asp Tyr Ile Tyr Asn Xaa Asp Gln Ser Lys Asp Ser Leu 
            340                 345                 350         


Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile Ala Ala Val Asp 
        355                 360                 365             


Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn Asn Tyr His Val 
    370                 375                 380                 


Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser Arg Ser Gly Gln 
385                 390                 395                 400 


Ala His His Gly Gln Val Ser Tyr Ile Ser Pro Pro Ile His Leu Asp 
                405                 410                 415     


Ser Glu Leu Glu Arg Pro Ser Val Lys Asp Ile Ser Xaa Xaa Gly Pro 
            420                 425                 430         


Leu Gly Met Gly Ser Xaa Xaa Xaa Ser Xaa Xaa Leu Arg Xaa Xaa Xaa 
        435                 440                 445             


Leu Ser Pro Gly Arg Ser Xaa Xaa Pro Ser Val Ser Gly Arg Arg Asn 
    450                 455                 460                 


Arg Ser Xaa Ser Xaa Pro Ser Pro Ala Val Glu Val Leu Asp Asp Met 
465                 470                 475                 480 


Xaa Xaa His Leu Pro Ser Ala Ser Ser Gln Ile Pro Ala Leu Glu Glu 
                485                 490                 495     


Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp Phe Lys Xaa Arg 
            500                 505                 510         


Gln Gly Gln Ile Ala Lys Gln Pro Cys Pro Ala Gly Xaa Ile Gly Val 
        515                 520                 525             


Ser Xaa Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp Asp Pro Gln Gly 
    530                 535                 540                 


Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn His Ile Xaa Gln 
545                 550                 555                 560 


Lys Leu Lys Ser Gly Glu Xaa Ala Ala Asn Ile Ala Arg Glu Leu Ala 
                565                 570                 575     


Glu Gln Xaa Arg Asn His Leu Asn Ala Gly Asp Ile Xaa Tyr Ser Val 
            580                 585                 590         


Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val Gln Leu Arg Asn 
        595                 600                 605             


Leu Xaa Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser Leu Asn Lys Leu 
    610                 615                 620                 


Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln Ala Met Val Glu 
625                 630                 635                 640 


Xaa Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn Ala Trp Arg Asp 
                645                 650                 655     


Leu Xaa Xaa Ser Asp Gln Leu Arg Ala Ala Xaa Met Leu Leu His Xaa 
            660                 665                 670         


Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu Leu Lys Xaa Asp 
        675                 680                 685             


Ile Val Arg Glu Asn Xaa Asp Asn Ile Lys Leu Glu Val Ala Arg Leu 
    690                 695                 700                 


Ser Xaa Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro Glu Asn Met Gly 
705                 710                 715                 720 


His Gly Ser Xaa Ile Gln Leu Ser Ala Asn Xaa Leu Lys Gln Asn Gly 
                725                 730                 735     


Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr Asn Asn Leu Gly 
            740                 745                 750         


Pro Tyr Leu Ser Xaa Glu Asn Ala Ser Met Lys Leu Gly Xaa Glu Ala 
        755                 760                 765             


Leu Ser Xaa Asn His Ser Val Ile Val Asn Ser Pro Val Ile Xaa Ala 
    770                 775                 780                 


Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu Ala Asp Pro Val 
785                 790                 795                 800 


Val Phe Xaa Val Lys His Ile Lys Gln Ser Glu Glu Asn Phe Asn Pro 
                805                 810                 815     


Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Xaa Met Xaa Gly Tyr Trp 
            820                 825                 830         


Ser Xaa Gln Gly Cys Arg Leu Leu Xaa Xaa Asn Lys Xaa His Xaa Xaa 
        835                 840                 845             


Cys Ser Cys Asn His Leu Xaa Asn Phe Ala Val Leu Met Ala His Val 
    850                 855                 860                 


Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu Leu Asp Val Ile 
865                 870                 875                 880 


Xaa Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu Leu Ile Cys Ile 
                885                 890                 895     


Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn Xaa Ile 
            900                 905                 910         


His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu Leu Leu Phe Leu 
        915                 920                 925             


Ile Gly Ile Asn Arg Xaa Asp Gln Pro Ile Ala Cys Ala Val Phe Ala 
    930                 935                 940                 


Ala Leu Leu His Phe Phe Phe Leu Ala Ala Phe Xaa Trp Met Phe Leu 
945                 950                 955                 960 


Glu Gly Val Gln Leu Tyr Ile Met Leu Val Glu Val Phe Glu Ser Glu 
                965                 970                 975     


His Ser Arg Arg Lys Tyr Phe Tyr Leu Val Gly Tyr Gly Met Pro Ala 
            980                 985                 990         


Leu Ile Val Ala Val Ser Ala Ala  Val Asp Tyr Arg Ser  Tyr Gly Xaa 
        995                 1000                 1005             


Asp Lys  Val Cys Trp Leu Arg  Leu Asp Xaa Tyr Phe  Ile Trp Ser 
    1010                 1015                 1020             


Phe Ile  Gly Pro Ala Xaa Leu  Ile Ile Met Leu Asn  Val Ile Phe 
    1025                 1030                 1035             


Leu Gly  Ile Ala Leu Tyr Lys  Met Phe His His Xaa  Ala Ile Leu 
    1040                 1045                 1050             


Lys Pro  Glu Ser Gly Cys Leu  Asp Asn Ile Asn Tyr  Glu Asp Asn 
    1055                 1060                 1065             


Arg Pro  Phe Ile Lys Ser Trp  Val Ile Gly Ala Ile  Ala Leu Leu 
    1070                 1075                 1080             


Cys Leu  Leu Gly Leu Xaa Trp  Ala Phe Gly Leu Met  Tyr Ile Asn 
    1085                 1090                 1095             


Glu Ser  Xaa Val Ile Met Ala  Tyr Leu Phe Xaa Ile  Phe Asn Ser 
    1100                 1105                 1110             


Leu Gln  Gly Met Phe Ile Phe  Ile Phe His Cys Val  Leu Gln Lys 
    1115                 1120                 1125             


Lys Val  Arg Lys Glu Tyr Gly  Lys Cys Leu Arg Xaa  His Cys Cys 
    1130                 1135                 1140             


Ser Gly  Lys Ser Xaa Glu Ser  Ser Ile Gly Ser Gly  Lys Xaa Ser 
    1145                 1150                 1155             


Gly Ser  Arg Xaa Pro Gly Arg  Tyr Ser Xaa Gly Ser  Gln Ser Arg 
    1160                 1165                 1170             


Ile Arg  Arg Met Trp Asn Asp  Xaa Val Arg Lys Gln  Ser Glu Ser 
    1175                 1180                 1185             


Ser Phe  Ile Xaa Gly Asp Ile  Asn Ser Ser Ala Ser  Leu Asn Arg 
    1190                 1195                 1200             


Glu Gly  Leu Leu Asn Asn Ala  Arg Asp Xaa Ser Val  Met Asp Xaa 
    1205                 1210                 1215             


Leu Pro  Leu Asn Gly Asn His  Gly Asn Ser Tyr Ser  Ile Ala Ser 
    1220                 1225                 1230             


Gly Glu  Tyr Leu Ser Asn Cys  Val Gln Ile Ile Asp  Arg Gly Tyr 
    1235                 1240                 1245             


Asn His  Asn Glu Xaa Ala Leu  Glu Lys Lys Ile Leu  Lys Glu Leu 
    1250                 1255                 1260             


Xaa Ser  Asn Tyr Ile Pro Ser  Tyr Leu Asn Asn His  Glu Arg Ser 
    1265                 1270                 1275             


Ser Glu  Gln Asn Arg Asn Leu  Met Asn Lys Leu Val  Asn Asn Leu 
    1280                 1285                 1290             


Gly Ser  Gly Arg Glu Asp Asp  Ala Ile Val Leu Asp  Asp Ala Xaa 
    1295                 1300                 1305             


Ser Phe  Asn His Glu Glu Ser  Leu Gly Leu Glu Leu  Ile His Glu 
    1310                 1315                 1320             


Glu Ser  Asp Ala Pro Leu Leu  Pro Pro Arg Val Tyr  Ser Xaa Glu 
    1325                 1330                 1335             


Asn His  Gln Pro His His Tyr  Xaa Arg Arg Arg Ile  Pro Gln Asp 
    1340                 1345                 1350             


His Ser  Glu Ser Phe Phe Pro  Leu Leu Xaa Asn Glu  His Xaa Glu 
    1355                 1360                 1365             


Asp Leu  Gln Ser Pro His Arg  Asp Ser Leu Tyr Xaa  Ser Met Pro 
    1370                 1375                 1380             


Xaa Leu  Ala Gly Val Ala Ala  Xaa Glu Ser Val Xaa  Xaa Ser Xaa 
    1385                 1390                 1395             


Gln Xaa  Glu Pro Pro Pro Ala  Lys Cys Gly Asp Ala  Glu Asp Val 
    1400                 1405                 1410             


Tyr Tyr  Lys Ser Met Pro Asn  Leu Gly Ser Arg Asn  His Val His 
    1415                 1420                 1425             


Gln Leu  His Xaa Tyr Tyr Gln  Leu Gly Arg Gly Ser  Ser Asp Gly 
    1430                 1435                 1440             


Phe Ile  Val Pro Pro Asn Lys  Asp Gly Xaa Pro Pro  Glu Gly Ser 
    1445                 1450                 1455             


Ser Lys  Gly Pro Ala His Leu  Val Xaa Ser Leu 
    1460                 1465                 


<210> 1777
<211> 1503
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1131)..(1131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1218)..(1218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1247)..(1247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1252)..(1252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1287)..(1287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1298)..(1298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1342)..(1342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1380)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1397)..(1397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1418)..(1418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1425)..(1425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1429)..(1430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1432)..(1432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1466)..(1466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1487)..(1487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1501)..(1501)
<223> Selenocysteine

<400> 1777
Met Trp Pro Ser Gln Leu Leu Ile Phe Met Met Leu Leu Ala Pro Ile 
1               5                   10                  15      


Ile His Ala Phe Ser Arg Ala Pro Ile Pro Met Ala Val Val Arg Arg 
            20                  25                  30          


Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg Cys Pro Gly Xaa 
        35                  40                  45              


Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg Xaa Asp Asp Lys 
    50                  55                  60                  


Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile Arg Cys Tyr Leu 
65                  70                  75                  80  


Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn Asn Arg Xaa Gln 
                85                  90                  95      


Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp Pro Cys Pro Gly 
            100                 105                 110         


Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val Pro Tyr Lys Val 
        115                 120                 125             


Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys Gly Val Tyr Gln 
    130                 135                 140                 


Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly Ala Trp Cys Lys 
145                 150                 155                 160 


Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met Pro Trp Xaa Pro 
                165                 170                 175     


Tyr Arg Xaa Asp Xaa Leu Xaa Glu Tyr Ser Ser Lys Asp Asp Phe Ile 
            180                 185                 190         


Ala Gly Arg Pro Xaa Xaa Xaa Tyr Lys Leu Pro His Arg Val Asp Gly 
        195                 200                 205             


Xaa Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe Asn Lys Glu Arg 
    210                 215                 220                 


Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg Ile Lys Ser Gly 
225                 230                 235                 240 


Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Xaa Ser Pro Tyr Arg 
                245                 250                 255     


Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp Glu Asn Gly Leu 
            260                 265                 270         


Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Lys Ile Val Ile Ser 
        275                 280                 285             


Gln Leu Asn Pro Tyr Xaa Leu Arg Ile Glu Gly Xaa Trp Asp Xaa Ala 
    290                 295                 300                 


Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile Cys Gly Ile Leu 
305                 310                 315                 320 


Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn Glu Ala Xaa Gly 
                325                 330                 335     


Asn Lys Ile Asp Tyr Ile Tyr Asn Xaa Asp Gln Ser Lys Asp Ser Leu 
            340                 345                 350         


Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile Ala Ala Val Asp 
        355                 360                 365             


Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn Asn Tyr His Val 
    370                 375                 380                 


Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser Arg Ser Gly Gln 
385                 390                 395                 400 


Ala His His Gly Gln Val Ser Tyr Ile Ser Pro Pro Ile His Leu Asp 
                405                 410                 415     


Ser Glu Leu Glu Arg Pro Ser Val Lys Asp Ile Ser Xaa Xaa Gly Pro 
            420                 425                 430         


Leu Gly Met Gly Ser Xaa Xaa Xaa Ser Xaa Xaa Leu Arg Xaa Xaa Xaa 
        435                 440                 445             


Leu Ser Pro Gly Arg Ser Xaa Xaa Pro Ser Val Ser Gly Arg Arg Asn 
    450                 455                 460                 


Arg Ser Xaa Ser Xaa Pro Ser Pro Ala Val Glu Val Leu Asp Asp Met 
465                 470                 475                 480 


Xaa Xaa His Leu Pro Ser Ala Ser Ser Gln Ile Pro Ala Leu Glu Glu 
                485                 490                 495     


Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp Phe Lys Xaa Arg 
            500                 505                 510         


Gln Gly Gln Ile Ala Lys Gln Pro Cys Pro Ala Gly Xaa Ile Gly Val 
        515                 520                 525             


Ser Xaa Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp Asp Pro Gln Gly 
    530                 535                 540                 


Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn His Ile Xaa Gln 
545                 550                 555                 560 


Lys Leu Lys Ser Gly Glu Xaa Ala Ala Asn Ile Ala Arg Glu Leu Ala 
                565                 570                 575     


Glu Gln Xaa Arg Asn His Leu Asn Ala Gly Asp Ile Xaa Tyr Ser Val 
            580                 585                 590         


Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val Gln Leu Arg Asn 
        595                 600                 605             


Leu Xaa Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser Leu Asn Lys Leu 
    610                 615                 620                 


Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln Ala Met Val Glu 
625                 630                 635                 640 


Xaa Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn Ala Trp Arg Asp 
                645                 650                 655     


Leu Xaa Xaa Ser Asp Gln Leu Arg Ala Ala Xaa Met Leu Leu His Xaa 
            660                 665                 670         


Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu Leu Lys Xaa Asp 
        675                 680                 685             


Ile Val Arg Glu Asn Xaa Asp Asn Ile Lys Leu Glu Val Ala Arg Leu 
    690                 695                 700                 


Ser Xaa Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro Glu Asn Met Gly 
705                 710                 715                 720 


His Gly Ser Xaa Ile Gln Leu Ser Ala Asn Xaa Leu Lys Gln Asn Gly 
                725                 730                 735     


Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr Asn Asn Leu Gly 
            740                 745                 750         


Pro Tyr Leu Ser Xaa Glu Asn Ala Ser Met Lys Leu Gly Xaa Glu Ala 
        755                 760                 765             


Leu Ser Xaa Asn His Ser Val Ile Val Asn Ser Pro Val Ile Xaa Ala 
    770                 775                 780                 


Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu Ala Asp Pro Val 
785                 790                 795                 800 


Val Phe Xaa Val Lys His Ile Lys Gln Ser Glu Glu Asn Phe Asn Pro 
                805                 810                 815     


Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Xaa Met Xaa Gly Tyr Trp 
            820                 825                 830         


Ser Xaa Gln Gly Cys Arg Leu Leu Xaa Xaa Asn Lys Xaa His Xaa Xaa 
        835                 840                 845             


Cys Ser Cys Asn His Leu Xaa Asn Phe Ala Val Leu Met Ala His Val 
    850                 855                 860                 


Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu Leu Asp Val Ile 
865                 870                 875                 880 


Xaa Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu Leu Ile Cys Ile 
                885                 890                 895     


Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn Xaa Ile 
            900                 905                 910         


His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu Leu Leu Phe Leu 
        915                 920                 925             


Ile Gly Ile Asn Arg Xaa Asp Gln Pro Ile Ala Cys Ala Val Phe Ala 
    930                 935                 940                 


Ala Leu Leu His Phe Phe Phe Leu Ala Ala Phe Xaa Trp Met Phe Leu 
945                 950                 955                 960 


Glu Gly Val Gln Leu Tyr Ile Met Leu Val Glu Val Phe Glu Ser Glu 
                965                 970                 975     


His Ser Arg Arg Lys Tyr Phe Tyr Leu Val Gly Tyr Gly Met Pro Ala 
            980                 985                 990         


Leu Ile Val Ala Val Ser Ala Ala  Val Asp Tyr Arg Ser  Tyr Gly Xaa 
        995                 1000                 1005             


Asp Lys  Val Cys Trp Leu Arg  Leu Asp Xaa Tyr Phe  Ile Trp Ser 
    1010                 1015                 1020             


Phe Ile  Gly Pro Ala Xaa Leu  Ile Ile Met Leu Asn  Val Ile Phe 
    1025                 1030                 1035             


Leu Gly  Ile Ala Leu Tyr Lys  Met Phe His His Xaa  Ala Ile Leu 
    1040                 1045                 1050             


Lys Pro  Glu Ser Gly Cys Leu  Asp Asn Ile Lys Ser  Trp Val Ile 
    1055                 1060                 1065             


Gly Ala  Ile Ala Leu Leu Cys  Leu Leu Gly Leu Xaa  Trp Ala Phe 
    1070                 1075                 1080             


Gly Leu  Met Tyr Ile Asn Glu  Ser Xaa Val Ile Met  Ala Tyr Leu 
    1085                 1090                 1095             


Phe Xaa  Ile Phe Asn Ser Leu  Gln Gly Met Phe Ile  Phe Ile Phe 
    1100                 1105                 1110             


His Cys  Val Leu Gln Lys Lys  Val Arg Lys Glu Tyr  Gly Lys Cys 
    1115                 1120                 1125             


Leu Arg  Xaa His Cys Cys Ser  Gly Lys Ser Xaa Glu  Ser Ser Ile 
    1130                 1135                 1140             


Gly Ser  Gly Lys Xaa Ser Gly  Ser Arg Xaa Pro Gly  Arg Tyr Ser 
    1145                 1150                 1155             


Xaa Gly  Ser Gln Ser Arg Ile  Arg Arg Met Trp Asn  Asp Xaa Val 
    1160                 1165                 1170             


Arg Lys  Gln Ser Glu Ser Ser  Phe Ile Xaa Gly Asp  Ile Asn Ser 
    1175                 1180                 1185             


Ser Ala  Ser Leu Asn Arg Gly  Ala Met Ala Asn His  Leu Ile Ser 
    1190                 1195                 1200             


Asn Ala  Leu Leu Arg Pro His  Gly Xaa Asn Asn Pro  Tyr Asn Xaa 
    1205                 1210                 1215             


Leu Leu  Gly Glu Pro Ala Val  Cys Asn Asn Pro Ser  Val Ser Met 
    1220                 1225                 1230             


Tyr Asn  Ala Gln Glu Gly Leu  Leu Asn Asn Ala Arg  Asp Xaa Ser 
    1235                 1240                 1245             


Val Met  Asp Xaa Leu Pro Leu  Asn Gly Asn His Gly  Asn Ser Tyr 
    1250                 1255                 1260             


Ser Ile  Ala Ser Gly Glu Tyr  Leu Ser Asn Cys Val  Gln Ile Ile 
    1265                 1270                 1275             


Asp Arg  Gly Tyr Asn His Asn  Glu Xaa Ala Leu Glu  Lys Lys Ile 
    1280                 1285                 1290             


Leu Lys  Glu Leu Xaa Ser Asn  Tyr Ile Pro Ser Tyr  Leu Asn Asn 
    1295                 1300                 1305             


His Glu  Arg Ser Ser Glu Gln  Asn Arg Asn Leu Met  Asn Lys Leu 
    1310                 1315                 1320             


Val Asn  Asn Leu Gly Ser Gly  Arg Glu Asp Asp Ala  Ile Val Leu 
    1325                 1330                 1335             


Asp Asp  Ala Xaa Ser Phe Asn  His Glu Glu Ser Leu  Gly Leu Glu 
    1340                 1345                 1350             


Leu Ile  His Glu Glu Ser Asp  Ala Pro Leu Leu Pro  Pro Arg Val 
    1355                 1360                 1365             


Tyr Ser  Xaa Glu Asn His Gln  Pro His His Tyr Xaa  Arg Arg Arg 
    1370                 1375                 1380             


Ile Pro  Gln Asp His Ser Glu  Ser Phe Phe Pro Leu  Leu Xaa Asn 
    1385                 1390                 1395             


Glu His  Xaa Glu Asp Leu Gln  Ser Pro His Arg Asp  Ser Leu Tyr 
    1400                 1405                 1410             


Xaa Ser  Met Pro Xaa Leu Ala  Gly Val Ala Ala Xaa  Glu Ser Val 
    1415                 1420                 1425             


Xaa Xaa  Ser Xaa Gln Xaa Glu  Pro Pro Pro Ala Lys  Cys Gly Asp 
    1430                 1435                 1440             


Ala Glu  Asp Val Tyr Tyr Lys  Ser Met Pro Asn Leu  Gly Ser Arg 
    1445                 1450                 1455             


Asn His  Val His Gln Leu His  Xaa Tyr Tyr Gln Leu  Gly Arg Gly 
    1460                 1465                 1470             


Ser Ser  Asp Gly Phe Ile Val  Pro Pro Asn Lys Asp  Gly Xaa Pro 
    1475                 1480                 1485             


Pro Glu  Gly Ser Ser Lys Gly  Pro Ala His Leu Val  Xaa Ser Leu 
    1490                 1495                 1500             


<210> 1778
<211> 1512
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1221)..(1221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1296)..(1296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1380)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1406)..(1406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1410)..(1410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1438)..(1439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1443)..(1443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1475)..(1475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1496)..(1496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1510)..(1510)
<223> Selenocysteine

<400> 1778
Met Trp Pro Ser Gln Leu Leu Ile Phe Met Met Leu Leu Ala Pro Ile 
1               5                   10                  15      


Ile His Ala Phe Ser Arg Ala Pro Ile Pro Met Ala Val Val Arg Arg 
            20                  25                  30          


Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg Cys Pro Gly Xaa 
        35                  40                  45              


Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg Xaa Asp Asp Lys 
    50                  55                  60                  


Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile Arg Cys Tyr Leu 
65                  70                  75                  80  


Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn Asn Arg Xaa Gln 
                85                  90                  95      


Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp Pro Cys Pro Gly 
            100                 105                 110         


Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val Pro Tyr Lys Val 
        115                 120                 125             


Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys Gly Val Tyr Gln 
    130                 135                 140                 


Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly Ala Trp Cys Lys 
145                 150                 155                 160 


Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met Pro Trp Xaa Pro 
                165                 170                 175     


Tyr Arg Xaa Asp Xaa Leu Xaa Glu Tyr Ser Ser Lys Asp Asp Phe Ile 
            180                 185                 190         


Ala Gly Arg Pro Xaa Xaa Xaa Tyr Lys Leu Pro His Arg Val Asp Gly 
        195                 200                 205             


Xaa Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe Asn Lys Glu Arg 
    210                 215                 220                 


Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg Ile Lys Ser Gly 
225                 230                 235                 240 


Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Xaa Ser Pro Tyr Arg 
                245                 250                 255     


Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp Glu Asn Gly Leu 
            260                 265                 270         


Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Lys Ile Val Ile Ser 
        275                 280                 285             


Gln Leu Asn Pro Tyr Xaa Leu Arg Ile Glu Gly Xaa Trp Asp Xaa Ala 
    290                 295                 300                 


Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile Cys Gly Ile Leu 
305                 310                 315                 320 


Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn Glu Ala Xaa Gly 
                325                 330                 335     


Asn Lys Ile Asp Tyr Ile Tyr Asn Xaa Asp Gln Ser Lys Asp Ser Leu 
            340                 345                 350         


Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile Ala Ala Val Asp 
        355                 360                 365             


Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn Asn Tyr His Val 
    370                 375                 380                 


Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser Arg Ser Gly Gln 
385                 390                 395                 400 


Ala His His Gly Gln Val Ser Tyr Ile Ser Pro Pro Ile His Leu Asp 
                405                 410                 415     


Ser Glu Leu Glu Arg Pro Ser Val Lys Asp Ile Ser Xaa Xaa Gly Pro 
            420                 425                 430         


Leu Gly Met Gly Ser Xaa Xaa Xaa Ser Xaa Xaa Leu Arg Xaa Xaa Xaa 
        435                 440                 445             


Leu Ser Pro Gly Arg Ser Xaa Xaa Pro Ser Val Ser Gly Arg Arg Asn 
    450                 455                 460                 


Arg Ser Xaa Ser Xaa Pro Ser Pro Ala Val Glu Val Leu Asp Asp Met 
465                 470                 475                 480 


Xaa Xaa His Leu Pro Ser Ala Ser Ser Gln Ile Pro Ala Leu Glu Glu 
                485                 490                 495     


Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp Phe Lys Xaa Arg 
            500                 505                 510         


Gln Gly Gln Ile Ala Lys Gln Pro Cys Pro Ala Gly Xaa Ile Gly Val 
        515                 520                 525             


Ser Xaa Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp Asp Pro Gln Gly 
    530                 535                 540                 


Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn His Ile Xaa Gln 
545                 550                 555                 560 


Lys Leu Lys Ser Gly Glu Xaa Ala Ala Asn Ile Ala Arg Glu Leu Ala 
                565                 570                 575     


Glu Gln Xaa Arg Asn His Leu Asn Ala Gly Asp Ile Xaa Tyr Ser Val 
            580                 585                 590         


Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val Gln Leu Arg Asn 
        595                 600                 605             


Leu Xaa Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser Leu Asn Lys Leu 
    610                 615                 620                 


Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln Ala Met Val Glu 
625                 630                 635                 640 


Xaa Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn Ala Trp Arg Asp 
                645                 650                 655     


Leu Xaa Xaa Ser Asp Gln Leu Arg Ala Ala Xaa Met Leu Leu His Xaa 
            660                 665                 670         


Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu Leu Lys Xaa Asp 
        675                 680                 685             


Ile Val Arg Glu Asn Xaa Asp Asn Ile Lys Leu Glu Val Ala Arg Leu 
    690                 695                 700                 


Ser Xaa Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro Glu Asn Met Gly 
705                 710                 715                 720 


His Gly Ser Xaa Ile Gln Leu Ser Ala Asn Xaa Leu Lys Gln Asn Gly 
                725                 730                 735     


Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr Asn Asn Leu Gly 
            740                 745                 750         


Pro Tyr Leu Ser Xaa Glu Asn Ala Ser Met Lys Leu Gly Xaa Glu Ala 
        755                 760                 765             


Leu Ser Xaa Asn His Ser Val Ile Val Asn Ser Pro Val Ile Xaa Ala 
    770                 775                 780                 


Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu Ala Asp Pro Val 
785                 790                 795                 800 


Val Phe Xaa Val Lys His Ile Lys Gln Ser Glu Glu Asn Phe Asn Pro 
                805                 810                 815     


Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Xaa Met Xaa Gly Tyr Trp 
            820                 825                 830         


Ser Xaa Gln Gly Cys Arg Leu Leu Xaa Xaa Asn Lys Xaa His Xaa Xaa 
        835                 840                 845             


Cys Ser Cys Asn His Leu Xaa Asn Phe Ala Val Leu Met Ala His Val 
    850                 855                 860                 


Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu Leu Asp Val Ile 
865                 870                 875                 880 


Xaa Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu Leu Ile Cys Ile 
                885                 890                 895     


Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn Xaa Ile 
            900                 905                 910         


His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu Leu Leu Phe Leu 
        915                 920                 925             


Ile Gly Ile Asn Arg Xaa Asp Gln Pro Ile Ala Cys Ala Val Phe Ala 
    930                 935                 940                 


Ala Leu Leu His Phe Phe Phe Leu Ala Ala Phe Xaa Trp Met Phe Leu 
945                 950                 955                 960 


Glu Gly Val Gln Leu Tyr Ile Met Leu Val Glu Val Phe Glu Ser Glu 
                965                 970                 975     


His Ser Arg Arg Lys Tyr Phe Tyr Leu Val Gly Tyr Gly Met Pro Ala 
            980                 985                 990         


Leu Ile Val Ala Val Ser Ala Ala  Val Asp Tyr Arg Ser  Tyr Gly Xaa 
        995                 1000                 1005             


Asp Lys  Val Cys Trp Leu Arg  Leu Asp Xaa Tyr Phe  Ile Trp Ser 
    1010                 1015                 1020             


Phe Ile  Gly Pro Ala Xaa Leu  Ile Ile Met Leu Asn  Val Ile Phe 
    1025                 1030                 1035             


Leu Gly  Ile Ala Leu Tyr Lys  Met Phe His His Xaa  Ala Ile Leu 
    1040                 1045                 1050             


Lys Pro  Glu Ser Gly Cys Leu  Asp Asn Ile Asn Tyr  Glu Asp Asn 
    1055                 1060                 1065             


Arg Pro  Phe Ile Lys Ser Trp  Val Ile Gly Ala Ile  Ala Leu Leu 
    1070                 1075                 1080             


Cys Leu  Leu Gly Leu Xaa Trp  Ala Phe Gly Leu Met  Tyr Ile Asn 
    1085                 1090                 1095             


Glu Ser  Xaa Val Ile Met Ala  Tyr Leu Phe Xaa Ile  Phe Asn Ser 
    1100                 1105                 1110             


Leu Gln  Gly Met Phe Ile Phe  Ile Phe His Cys Val  Leu Gln Lys 
    1115                 1120                 1125             


Lys Val  Arg Lys Glu Tyr Gly  Lys Cys Leu Arg Xaa  His Cys Cys 
    1130                 1135                 1140             


Ser Gly  Lys Ser Xaa Glu Ser  Ser Ile Gly Ser Gly  Lys Xaa Ser 
    1145                 1150                 1155             


Gly Ser  Arg Xaa Pro Gly Arg  Tyr Ser Xaa Gly Ser  Gln Ser Arg 
    1160                 1165                 1170             


Ile Arg  Arg Met Trp Asn Asp  Xaa Val Arg Lys Gln  Ser Glu Ser 
    1175                 1180                 1185             


Ser Phe  Ile Xaa Gly Asp Ile  Asn Ser Ser Ala Ser  Leu Asn Arg 
    1190                 1195                 1200             


Gly Ala  Met Ala Asn His Leu  Ile Ser Asn Ala Leu  Leu Arg Pro 
    1205                 1210                 1215             


His Gly  Xaa Asn Asn Pro Tyr  Asn Xaa Leu Leu Gly  Glu Pro Ala 
    1220                 1225                 1230             


Val Cys  Asn Asn Pro Ser Val  Ser Met Tyr Asn Ala  Gln Glu Gly 
    1235                 1240                 1245             


Leu Leu  Asn Asn Ala Arg Asp  Xaa Ser Val Met Asp  Xaa Leu Pro 
    1250                 1255                 1260             


Leu Asn  Gly Asn His Gly Asn  Ser Tyr Ser Ile Ala  Ser Gly Glu 
    1265                 1270                 1275             


Tyr Leu  Ser Asn Cys Val Gln  Ile Ile Asp Arg Gly  Tyr Asn His 
    1280                 1285                 1290             


Asn Glu  Xaa Ala Leu Glu Lys  Lys Ile Leu Lys Glu  Leu Xaa Ser 
    1295                 1300                 1305             


Asn Tyr  Ile Pro Ser Tyr Leu  Asn Asn His Glu Arg  Ser Ser Glu 
    1310                 1315                 1320             


Gln Asn  Arg Asn Leu Met Asn  Lys Leu Val Asn Asn  Leu Gly Ser 
    1325                 1330                 1335             


Gly Arg  Glu Asp Asp Ala Ile  Val Leu Asp Asp Ala  Xaa Ser Phe 
    1340                 1345                 1350             


Asn His  Glu Glu Ser Leu Gly  Leu Glu Leu Ile His  Glu Glu Ser 
    1355                 1360                 1365             


Asp Ala  Pro Leu Leu Pro Pro  Arg Val Tyr Ser Xaa  Glu Asn His 
    1370                 1375                 1380             


Gln Pro  His His Tyr Xaa Arg  Arg Arg Ile Pro Gln  Asp His Ser 
    1385                 1390                 1395             


Glu Ser  Phe Phe Pro Leu Leu  Xaa Asn Glu His Xaa  Glu Asp Leu 
    1400                 1405                 1410             


Gln Ser  Pro His Arg Asp Ser  Leu Tyr Xaa Ser Met  Pro Xaa Leu 
    1415                 1420                 1425             


Ala Gly  Val Ala Ala Xaa Glu  Ser Val Xaa Xaa Ser  Xaa Gln Xaa 
    1430                 1435                 1440             


Glu Pro  Pro Pro Ala Lys Cys  Gly Asp Ala Glu Asp  Val Tyr Tyr 
    1445                 1450                 1455             


Lys Ser  Met Pro Asn Leu Gly  Ser Arg Asn His Val  His Gln Leu 
    1460                 1465                 1470             


His Xaa  Tyr Tyr Gln Leu Gly  Arg Gly Ser Ser Asp  Gly Phe Ile 
    1475                 1480                 1485             


Val Pro  Pro Asn Lys Asp Gly  Xaa Pro Pro Glu Gly  Ser Ser Lys 
    1490                 1495                 1500             


Gly Pro  Ala His Leu Val Xaa  Ser Leu 
    1505                 1510         


<210> 1779
<211> 1299
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1221)..(1221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1240)..(1240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1268)..(1268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1296)..(1297)
<223> Selenocysteine

<400> 1779
Met Trp Pro Ser Gln Leu Leu Ile Phe Met Met Leu Leu Ala Pro Ile 
1               5                   10                  15      


Ile His Gly Gly Lys His Ser Glu Arg His Pro Ala Leu Ala Ala Pro 
            20                  25                  30          


Leu Arg His Ala Glu Arg Ser Pro Gly Gly Ala Leu Pro Pro Arg His 
        35                  40                  45              


Leu Leu Gln Gln Pro Ala Ala Glu Arg Xaa Ala Ala His Arg Gly Gln 
    50                  55                  60                  


Gly Pro Arg Gly Ala Xaa Arg Gly Val Arg Gly Pro Gly Ala Gln Gly 
65                  70                  75                  80  


Ala Gln Ile Ala Ala Gln Ala Phe Ser Arg Ala Pro Ile Pro Met Ala 
                85                  90                  95      


Val Val Arg Arg Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg 
            100                 105                 110         


Cys Pro Gly Xaa Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg 
        115                 120                 125             


Xaa Asp Asp Lys Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile 
    130                 135                 140                 


Arg Cys Tyr Leu Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn 
145                 150                 155                 160 


Asn Arg Xaa Gln Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp 
                165                 170                 175     


Pro Cys Pro Gly Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val 
            180                 185                 190         


Pro Tyr Lys Val Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys 
        195                 200                 205             


Gly Val Tyr Gln Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly 
    210                 215                 220                 


Ala Trp Cys Lys Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met 
225                 230                 235                 240 


Pro Trp Xaa Pro Tyr Arg Xaa Asp Xaa Leu Xaa Glu Tyr Ser Ser Lys 
                245                 250                 255     


Asp Asp Phe Ile Ala Gly Arg Pro Xaa Xaa Xaa Tyr Lys Leu Pro His 
            260                 265                 270         


Arg Val Asp Gly Xaa Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe 
        275                 280                 285             


Asn Lys Glu Arg Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg 
    290                 295                 300                 


Ile Lys Ser Gly Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Xaa 
305                 310                 315                 320 


Ser Pro Tyr Arg Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp 
                325                 330                 335     


Glu Asn Gly Leu Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Lys 
            340                 345                 350         


Ile Val Ile Ser Gln Leu Asn Pro Tyr Xaa Leu Arg Ile Glu Gly Xaa 
        355                 360                 365             


Trp Asp Xaa Ala Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile 
    370                 375                 380                 


Cys Gly Ile Leu Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn 
385                 390                 395                 400 


Glu Ala Xaa Gly Asn Lys Ile Asp Tyr Ile Tyr Asn Xaa Asp Gln Ser 
                405                 410                 415     


Lys Asp Ser Leu Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile 
            420                 425                 430         


Ala Ala Val Asp Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn 
        435                 440                 445             


Asn Tyr His Val Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser 
    450                 455                 460                 


Arg Ser Gly Gln Ala His His Gly Gln Val Ser Tyr Ile Ser Pro Pro 
465                 470                 475                 480 


Ile His Leu Asp Ser Glu Leu Glu Arg Pro Ser Val Lys Asp Ile Ser 
                485                 490                 495     


Xaa Xaa Gly Pro Leu Gly Met Gly Ser Xaa Xaa Xaa Ser Xaa Xaa Leu 
            500                 505                 510         


Arg Xaa Xaa Xaa Leu Ser Pro Gly Arg Ser Xaa Xaa Pro Ser Val Ser 
        515                 520                 525             


Gly Arg Arg Asn Arg Ser Xaa Ser Xaa Pro Ser Pro Ala Val Glu Val 
    530                 535                 540                 


Leu Asp Asp Met Xaa Xaa His Leu Pro Ser Ala Ser Ser Gln Ile Pro 
545                 550                 555                 560 


Ala Leu Glu Glu Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp 
                565                 570                 575     


Phe Lys Xaa Arg Gln Gly Gln Ile Ala Lys Gln Pro Cys Pro Ala Gly 
            580                 585                 590         


Xaa Ile Gly Val Ser Xaa Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp 
        595                 600                 605             


Asp Pro Gln Gly Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn 
    610                 615                 620                 


His Ile Xaa Gln Lys Leu Lys Ser Gly Glu Xaa Ala Ala Asn Ile Ala 
625                 630                 635                 640 


Arg Glu Leu Ala Glu Gln Xaa Arg Asn His Leu Asn Ala Gly Asp Ile 
                645                 650                 655     


Xaa Tyr Ser Val Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val 
            660                 665                 670         


Gln Leu Arg Asn Leu Xaa Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser 
        675                 680                 685             


Leu Asn Lys Leu Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln 
    690                 695                 700                 


Ala Met Val Glu Xaa Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn 
705                 710                 715                 720 


Ala Trp Arg Asp Leu Xaa Xaa Ser Asp Gln Leu Arg Ala Ala Xaa Met 
                725                 730                 735     


Leu Leu His Xaa Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu 
            740                 745                 750         


Leu Lys Xaa Asp Ile Val Arg Glu Asn Xaa Asp Asn Ile Lys Leu Glu 
        755                 760                 765             


Val Ala Arg Leu Ser Xaa Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro 
    770                 775                 780                 


Glu Asn Met Gly His Gly Ser Xaa Ile Gln Leu Ser Ala Asn Xaa Leu 
785                 790                 795                 800 


Lys Gln Asn Gly Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr 
                805                 810                 815     


Asn Asn Leu Gly Pro Tyr Leu Ser Xaa Glu Asn Ala Ser Met Lys Leu 
            820                 825                 830         


Gly Xaa Glu Ala Leu Ser Xaa Asn His Ser Val Ile Val Asn Ser Pro 
        835                 840                 845             


Val Ile Xaa Ala Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu 
    850                 855                 860                 


Ala Asp Pro Val Val Phe Xaa Val Lys His Ile Lys Gln Ser Glu Glu 
865                 870                 875                 880 


Asn Phe Asn Pro Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Xaa Met 
                885                 890                 895     


Xaa Gly Tyr Trp Ser Xaa Gln Gly Cys Arg Leu Leu Xaa Xaa Asn Lys 
            900                 905                 910         


Xaa His Xaa Xaa Cys Ser Cys Asn His Leu Xaa Asn Phe Ala Val Leu 
        915                 920                 925             


Met Ala His Val Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu 
    930                 935                 940                 


Leu Asp Val Ile Xaa Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu 
945                 950                 955                 960 


Leu Ile Cys Ile Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp 
                965                 970                 975     


Arg Asn Xaa Ile His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu 
            980                 985                 990         


Leu Leu Phe Leu Ile Gly Ile Asn  Arg Xaa Asp Gln Pro  Ile Ala Cys 
        995                 1000                 1005             


Ala Val  Phe Ala Ala Leu Leu  His Phe Phe Phe Leu  Ala Ala Phe 
    1010                 1015                 1020             


Xaa Trp  Met Phe Leu Glu Gly  Val Gln Leu Tyr Ile  Met Leu Val 
    1025                 1030                 1035             


Glu Val  Phe Glu Ser Glu His  Ser Arg Arg Lys Tyr  Phe Tyr Leu 
    1040                 1045                 1050             


Val Gly  Tyr Gly Met Pro Ala  Leu Ile Val Ala Val  Ser Ala Ala 
    1055                 1060                 1065             


Val Asp  Tyr Arg Ser Tyr Gly  Xaa Asp Lys Val Cys  Trp Leu Arg 
    1070                 1075                 1080             


Leu Asp  Xaa Tyr Phe Ile Trp  Ser Phe Ile Gly Pro  Ala Xaa Leu 
    1085                 1090                 1095             


Ile Ile  Met Leu Asn Val Ile  Phe Leu Gly Ile Ala  Leu Tyr Lys 
    1100                 1105                 1110             


Met Phe  His His Xaa Ala Ile  Leu Lys Pro Glu Ser  Gly Cys Leu 
    1115                 1120                 1125             


Asp Asn  Ile Lys Ser Trp Val  Ile Gly Ala Ile Ala  Leu Leu Cys 
    1130                 1135                 1140             


Leu Leu  Gly Leu Xaa Trp Ala  Phe Gly Leu Met Tyr  Ile Asn Glu 
    1145                 1150                 1155             


Ser Xaa  Val Ile Met Ala Tyr  Leu Phe Xaa Ile Phe  Asn Ser Leu 
    1160                 1165                 1170             


Gln Gly  Met Phe Ile Phe Ile  Phe His Cys Val Leu  Gln Lys Lys 
    1175                 1180                 1185             


Val Arg  Lys Glu Tyr Gly Lys  Cys Leu Arg Xaa His  Cys Cys Ser 
    1190                 1195                 1200             


Gly Lys  Ser Xaa Glu Ser Ser  Ile Gly Ser Gly Lys  Xaa Ser Gly 
    1205                 1210                 1215             


Ser Arg  Xaa Pro Gly Arg Tyr  Ser Xaa Gly Ser Gln  Ser Arg Ile 
    1220                 1225                 1230             


Arg Arg  Met Trp Asn Asp Xaa  Val Arg Lys Gln Ser  Glu Ser Ser 
    1235                 1240                 1245             


Phe Ile  Xaa Gly Asp Ile Asn  Ser Ser Ala Ser Leu  Asn Arg Glu 
    1250                 1255                 1260             


Pro Tyr  Arg Glu Xaa Ser Met  Gly Val Lys Leu Asn  Ile Ala Tyr 
    1265                 1270                 1275             


Gln Ile  Gly Ala Ser Glu Gln  Cys Gln Gly Tyr Lys  Cys His Gly 
    1280                 1285                 1290             


Tyr Ser  Xaa Xaa Glu Trp 
    1295                 


<210> 1780
<211> 1308
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1208)..(1208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1260)..(1260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1277)..(1277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1306)
<223> Selenocysteine

<400> 1780
Met Trp Pro Ser Gln Leu Leu Ile Phe Met Met Leu Leu Ala Pro Ile 
1               5                   10                  15      


Ile His Gly Gly Lys His Ser Glu Arg His Pro Ala Leu Ala Ala Pro 
            20                  25                  30          


Leu Arg His Ala Glu Arg Ser Pro Gly Gly Ala Leu Pro Pro Arg His 
        35                  40                  45              


Leu Leu Gln Gln Pro Ala Ala Glu Arg Xaa Ala Ala His Arg Gly Gln 
    50                  55                  60                  


Gly Pro Arg Gly Ala Xaa Arg Gly Val Arg Gly Pro Gly Ala Gln Gly 
65                  70                  75                  80  


Ala Gln Ile Ala Ala Gln Ala Phe Ser Arg Ala Pro Ile Pro Met Ala 
                85                  90                  95      


Val Val Arg Arg Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg 
            100                 105                 110         


Cys Pro Gly Xaa Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg 
        115                 120                 125             


Xaa Asp Asp Lys Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile 
    130                 135                 140                 


Arg Cys Tyr Leu Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn 
145                 150                 155                 160 


Asn Arg Xaa Gln Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp 
                165                 170                 175     


Pro Cys Pro Gly Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val 
            180                 185                 190         


Pro Tyr Lys Val Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys 
        195                 200                 205             


Gly Val Tyr Gln Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly 
    210                 215                 220                 


Ala Trp Cys Lys Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met 
225                 230                 235                 240 


Pro Trp Xaa Pro Tyr Arg Xaa Asp Xaa Leu Xaa Glu Tyr Ser Ser Lys 
                245                 250                 255     


Asp Asp Phe Ile Ala Gly Arg Pro Xaa Xaa Xaa Tyr Lys Leu Pro His 
            260                 265                 270         


Arg Val Asp Gly Xaa Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe 
        275                 280                 285             


Asn Lys Glu Arg Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg 
    290                 295                 300                 


Ile Lys Ser Gly Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Xaa 
305                 310                 315                 320 


Ser Pro Tyr Arg Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp 
                325                 330                 335     


Glu Asn Gly Leu Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Lys 
            340                 345                 350         


Ile Val Ile Ser Gln Leu Asn Pro Tyr Xaa Leu Arg Ile Glu Gly Xaa 
        355                 360                 365             


Trp Asp Xaa Ala Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile 
    370                 375                 380                 


Cys Gly Ile Leu Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn 
385                 390                 395                 400 


Glu Ala Xaa Gly Asn Lys Ile Asp Tyr Ile Tyr Asn Xaa Asp Gln Ser 
                405                 410                 415     


Lys Asp Ser Leu Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile 
            420                 425                 430         


Ala Ala Val Asp Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn 
        435                 440                 445             


Asn Tyr His Val Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser 
    450                 455                 460                 


Arg Ser Gly Gln Ala His His Gly Gln Val Ser Tyr Ile Ser Pro Pro 
465                 470                 475                 480 


Ile His Leu Asp Ser Glu Leu Glu Arg Pro Ser Val Lys Asp Ile Ser 
                485                 490                 495     


Xaa Xaa Gly Pro Leu Gly Met Gly Ser Xaa Xaa Xaa Ser Xaa Xaa Leu 
            500                 505                 510         


Arg Xaa Xaa Xaa Leu Ser Pro Gly Arg Ser Xaa Xaa Pro Ser Val Ser 
        515                 520                 525             


Gly Arg Arg Asn Arg Ser Xaa Ser Xaa Pro Ser Pro Ala Val Glu Val 
    530                 535                 540                 


Leu Asp Asp Met Xaa Xaa His Leu Pro Ser Ala Ser Ser Gln Ile Pro 
545                 550                 555                 560 


Ala Leu Glu Glu Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp 
                565                 570                 575     


Phe Lys Xaa Arg Gln Gly Gln Ile Ala Lys Gln Pro Cys Pro Ala Gly 
            580                 585                 590         


Xaa Ile Gly Val Ser Xaa Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp 
        595                 600                 605             


Asp Pro Gln Gly Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn 
    610                 615                 620                 


His Ile Xaa Gln Lys Leu Lys Ser Gly Glu Xaa Ala Ala Asn Ile Ala 
625                 630                 635                 640 


Arg Glu Leu Ala Glu Gln Xaa Arg Asn His Leu Asn Ala Gly Asp Ile 
                645                 650                 655     


Xaa Tyr Ser Val Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val 
            660                 665                 670         


Gln Leu Arg Asn Leu Xaa Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser 
        675                 680                 685             


Leu Asn Lys Leu Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln 
    690                 695                 700                 


Ala Met Val Glu Xaa Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn 
705                 710                 715                 720 


Ala Trp Arg Asp Leu Xaa Xaa Ser Asp Gln Leu Arg Ala Ala Xaa Met 
                725                 730                 735     


Leu Leu His Xaa Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu 
            740                 745                 750         


Leu Lys Xaa Asp Ile Val Arg Glu Asn Xaa Asp Asn Ile Lys Leu Glu 
        755                 760                 765             


Val Ala Arg Leu Ser Xaa Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro 
    770                 775                 780                 


Glu Asn Met Gly His Gly Ser Xaa Ile Gln Leu Ser Ala Asn Xaa Leu 
785                 790                 795                 800 


Lys Gln Asn Gly Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr 
                805                 810                 815     


Asn Asn Leu Gly Pro Tyr Leu Ser Xaa Glu Asn Ala Ser Met Lys Leu 
            820                 825                 830         


Gly Xaa Glu Ala Leu Ser Xaa Asn His Ser Val Ile Val Asn Ser Pro 
        835                 840                 845             


Val Ile Xaa Ala Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu 
    850                 855                 860                 


Ala Asp Pro Val Val Phe Xaa Val Lys His Ile Lys Gln Ser Glu Glu 
865                 870                 875                 880 


Asn Phe Asn Pro Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Xaa Met 
                885                 890                 895     


Xaa Gly Tyr Trp Ser Xaa Gln Gly Cys Arg Leu Leu Xaa Xaa Asn Lys 
            900                 905                 910         


Xaa His Xaa Xaa Cys Ser Cys Asn His Leu Xaa Asn Phe Ala Val Leu 
        915                 920                 925             


Met Ala His Val Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu 
    930                 935                 940                 


Leu Asp Val Ile Xaa Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu 
945                 950                 955                 960 


Leu Ile Cys Ile Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp 
                965                 970                 975     


Arg Asn Xaa Ile His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu 
            980                 985                 990         


Leu Leu Phe Leu Ile Gly Ile Asn  Arg Xaa Asp Gln Pro  Ile Ala Cys 
        995                 1000                 1005             


Ala Val  Phe Ala Ala Leu Leu  His Phe Phe Phe Leu  Ala Ala Phe 
    1010                 1015                 1020             


Xaa Trp  Met Phe Leu Glu Gly  Val Gln Leu Tyr Ile  Met Leu Val 
    1025                 1030                 1035             


Glu Val  Phe Glu Ser Glu His  Ser Arg Arg Lys Tyr  Phe Tyr Leu 
    1040                 1045                 1050             


Val Gly  Tyr Gly Met Pro Ala  Leu Ile Val Ala Val  Ser Ala Ala 
    1055                 1060                 1065             


Val Asp  Tyr Arg Ser Tyr Gly  Xaa Asp Lys Val Cys  Trp Leu Arg 
    1070                 1075                 1080             


Leu Asp  Xaa Tyr Phe Ile Trp  Ser Phe Ile Gly Pro  Ala Xaa Leu 
    1085                 1090                 1095             


Ile Ile  Met Leu Asn Val Ile  Phe Leu Gly Ile Ala  Leu Tyr Lys 
    1100                 1105                 1110             


Met Phe  His His Xaa Ala Ile  Leu Lys Pro Glu Ser  Gly Cys Leu 
    1115                 1120                 1125             


Asp Asn  Ile Asn Tyr Glu Asp  Asn Arg Pro Phe Ile  Lys Ser Trp 
    1130                 1135                 1140             


Val Ile  Gly Ala Ile Ala Leu  Leu Cys Leu Leu Gly  Leu Xaa Trp 
    1145                 1150                 1155             


Ala Phe  Gly Leu Met Tyr Ile  Asn Glu Ser Xaa Val  Ile Met Ala 
    1160                 1165                 1170             


Tyr Leu  Phe Xaa Ile Phe Asn  Ser Leu Gln Gly Met  Phe Ile Phe 
    1175                 1180                 1185             


Ile Phe  His Cys Val Leu Gln  Lys Lys Val Arg Lys  Glu Tyr Gly 
    1190                 1195                 1200             


Lys Cys  Leu Arg Xaa His Cys  Cys Ser Gly Lys Ser  Xaa Glu Ser 
    1205                 1210                 1215             


Ser Ile  Gly Ser Gly Lys Xaa  Ser Gly Ser Arg Xaa  Pro Gly Arg 
    1220                 1225                 1230             


Tyr Ser  Xaa Gly Ser Gln Ser  Arg Ile Arg Arg Met  Trp Asn Asp 
    1235                 1240                 1245             


Xaa Val  Arg Lys Gln Ser Glu  Ser Ser Phe Ile Xaa  Gly Asp Ile 
    1250                 1255                 1260             


Asn Ser  Ser Ala Ser Leu Asn  Arg Glu Pro Tyr Arg  Glu Xaa Ser 
    1265                 1270                 1275             


Met Gly  Val Lys Leu Asn Ile  Ala Tyr Gln Ile Gly  Ala Ser Glu 
    1280                 1285                 1290             


Gln Cys  Gln Gly Tyr Lys Cys  His Gly Tyr Ser Xaa  Xaa Glu Trp 
    1295                 1300                 1305             


<210> 1781
<211> 1342
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1221)..(1221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1240)..(1240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1280)..(1280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1339)..(1340)
<223> Selenocysteine

<400> 1781
Met Trp Pro Ser Gln Leu Leu Ile Phe Met Met Leu Leu Ala Pro Ile 
1               5                   10                  15      


Ile His Gly Gly Lys His Ser Glu Arg His Pro Ala Leu Ala Ala Pro 
            20                  25                  30          


Leu Arg His Ala Glu Arg Ser Pro Gly Gly Ala Leu Pro Pro Arg His 
        35                  40                  45              


Leu Leu Gln Gln Pro Ala Ala Glu Arg Xaa Ala Ala His Arg Gly Gln 
    50                  55                  60                  


Gly Pro Arg Gly Ala Xaa Arg Gly Val Arg Gly Pro Gly Ala Gln Gly 
65                  70                  75                  80  


Ala Gln Ile Ala Ala Gln Ala Phe Ser Arg Ala Pro Ile Pro Met Ala 
                85                  90                  95      


Val Val Arg Arg Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg 
            100                 105                 110         


Cys Pro Gly Xaa Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg 
        115                 120                 125             


Xaa Asp Asp Lys Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile 
    130                 135                 140                 


Arg Cys Tyr Leu Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn 
145                 150                 155                 160 


Asn Arg Xaa Gln Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp 
                165                 170                 175     


Pro Cys Pro Gly Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val 
            180                 185                 190         


Pro Tyr Lys Val Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys 
        195                 200                 205             


Gly Val Tyr Gln Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly 
    210                 215                 220                 


Ala Trp Cys Lys Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met 
225                 230                 235                 240 


Pro Trp Xaa Pro Tyr Arg Xaa Asp Xaa Leu Xaa Glu Tyr Ser Ser Lys 
                245                 250                 255     


Asp Asp Phe Ile Ala Gly Arg Pro Xaa Xaa Xaa Tyr Lys Leu Pro His 
            260                 265                 270         


Arg Val Asp Gly Xaa Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe 
        275                 280                 285             


Asn Lys Glu Arg Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg 
    290                 295                 300                 


Ile Lys Ser Gly Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Xaa 
305                 310                 315                 320 


Ser Pro Tyr Arg Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp 
                325                 330                 335     


Glu Asn Gly Leu Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Lys 
            340                 345                 350         


Ile Val Ile Ser Gln Leu Asn Pro Tyr Xaa Leu Arg Ile Glu Gly Xaa 
        355                 360                 365             


Trp Asp Xaa Ala Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile 
    370                 375                 380                 


Cys Gly Ile Leu Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn 
385                 390                 395                 400 


Glu Ala Xaa Gly Asn Lys Ile Asp Tyr Ile Tyr Asn Xaa Asp Gln Ser 
                405                 410                 415     


Lys Asp Ser Leu Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile 
            420                 425                 430         


Ala Ala Val Asp Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn 
        435                 440                 445             


Asn Tyr His Val Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser 
    450                 455                 460                 


Arg Ser Gly Gln Ala His His Gly Gln Val Ser Tyr Ile Ser Pro Pro 
465                 470                 475                 480 


Ile His Leu Asp Ser Glu Leu Glu Arg Pro Ser Val Lys Asp Ile Ser 
                485                 490                 495     


Xaa Xaa Gly Pro Leu Gly Met Gly Ser Xaa Xaa Xaa Ser Xaa Xaa Leu 
            500                 505                 510         


Arg Xaa Xaa Xaa Leu Ser Pro Gly Arg Ser Xaa Xaa Pro Ser Val Ser 
        515                 520                 525             


Gly Arg Arg Asn Arg Ser Xaa Ser Xaa Pro Ser Pro Ala Val Glu Val 
    530                 535                 540                 


Leu Asp Asp Met Xaa Xaa His Leu Pro Ser Ala Ser Ser Gln Ile Pro 
545                 550                 555                 560 


Ala Leu Glu Glu Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp 
                565                 570                 575     


Phe Lys Xaa Arg Gln Gly Gln Ile Ala Lys Gln Pro Cys Pro Ala Gly 
            580                 585                 590         


Xaa Ile Gly Val Ser Xaa Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp 
        595                 600                 605             


Asp Pro Gln Gly Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn 
    610                 615                 620                 


His Ile Xaa Gln Lys Leu Lys Ser Gly Glu Xaa Ala Ala Asn Ile Ala 
625                 630                 635                 640 


Arg Glu Leu Ala Glu Gln Xaa Arg Asn His Leu Asn Ala Gly Asp Ile 
                645                 650                 655     


Xaa Tyr Ser Val Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val 
            660                 665                 670         


Gln Leu Arg Asn Leu Xaa Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser 
        675                 680                 685             


Leu Asn Lys Leu Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln 
    690                 695                 700                 


Ala Met Val Glu Xaa Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn 
705                 710                 715                 720 


Ala Trp Arg Asp Leu Xaa Xaa Ser Asp Gln Leu Arg Ala Ala Xaa Met 
                725                 730                 735     


Leu Leu His Xaa Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu 
            740                 745                 750         


Leu Lys Xaa Asp Ile Val Arg Glu Asn Xaa Asp Asn Ile Lys Leu Glu 
        755                 760                 765             


Val Ala Arg Leu Ser Xaa Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro 
    770                 775                 780                 


Glu Asn Met Gly His Gly Ser Xaa Ile Gln Leu Ser Ala Asn Xaa Leu 
785                 790                 795                 800 


Lys Gln Asn Gly Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr 
                805                 810                 815     


Asn Asn Leu Gly Pro Tyr Leu Ser Xaa Glu Asn Ala Ser Met Lys Leu 
            820                 825                 830         


Gly Xaa Glu Ala Leu Ser Xaa Asn His Ser Val Ile Val Asn Ser Pro 
        835                 840                 845             


Val Ile Xaa Ala Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu 
    850                 855                 860                 


Ala Asp Pro Val Val Phe Xaa Val Lys His Ile Lys Gln Ser Glu Glu 
865                 870                 875                 880 


Asn Phe Asn Pro Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Xaa Met 
                885                 890                 895     


Xaa Gly Tyr Trp Ser Xaa Gln Gly Cys Arg Leu Leu Xaa Xaa Asn Lys 
            900                 905                 910         


Xaa His Xaa Xaa Cys Ser Cys Asn His Leu Xaa Asn Phe Ala Val Leu 
        915                 920                 925             


Met Ala His Val Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu 
    930                 935                 940                 


Leu Asp Val Ile Xaa Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu 
945                 950                 955                 960 


Leu Ile Cys Ile Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp 
                965                 970                 975     


Arg Asn Xaa Ile His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu 
            980                 985                 990         


Leu Leu Phe Leu Ile Gly Ile Asn  Arg Xaa Asp Gln Pro  Ile Ala Cys 
        995                 1000                 1005             


Ala Val  Phe Ala Ala Leu Leu  His Phe Phe Phe Leu  Ala Ala Phe 
    1010                 1015                 1020             


Xaa Trp  Met Phe Leu Glu Gly  Val Gln Leu Tyr Ile  Met Leu Val 
    1025                 1030                 1035             


Glu Val  Phe Glu Ser Glu His  Ser Arg Arg Lys Tyr  Phe Tyr Leu 
    1040                 1045                 1050             


Val Gly  Tyr Gly Met Pro Ala  Leu Ile Val Ala Val  Ser Ala Ala 
    1055                 1060                 1065             


Val Asp  Tyr Arg Ser Tyr Gly  Xaa Asp Lys Val Cys  Trp Leu Arg 
    1070                 1075                 1080             


Leu Asp  Xaa Tyr Phe Ile Trp  Ser Phe Ile Gly Pro  Ala Xaa Leu 
    1085                 1090                 1095             


Ile Ile  Met Leu Asn Val Ile  Phe Leu Gly Ile Ala  Leu Tyr Lys 
    1100                 1105                 1110             


Met Phe  His His Xaa Ala Ile  Leu Lys Pro Glu Ser  Gly Cys Leu 
    1115                 1120                 1125             


Asp Asn  Ile Lys Ser Trp Val  Ile Gly Ala Ile Ala  Leu Leu Cys 
    1130                 1135                 1140             


Leu Leu  Gly Leu Xaa Trp Ala  Phe Gly Leu Met Tyr  Ile Asn Glu 
    1145                 1150                 1155             


Ser Xaa  Val Ile Met Ala Tyr  Leu Phe Xaa Ile Phe  Asn Ser Leu 
    1160                 1165                 1170             


Gln Gly  Met Phe Ile Phe Ile  Phe His Cys Val Leu  Gln Lys Lys 
    1175                 1180                 1185             


Val Arg  Lys Glu Tyr Gly Lys  Cys Leu Arg Xaa His  Cys Cys Ser 
    1190                 1195                 1200             


Gly Lys  Ser Xaa Glu Ser Ser  Ile Gly Ser Gly Lys  Xaa Ser Gly 
    1205                 1210                 1215             


Ser Arg  Xaa Pro Gly Arg Tyr  Ser Xaa Gly Ser Gln  Ser Arg Ile 
    1220                 1225                 1230             


Arg Arg  Met Trp Asn Asp Xaa  Val Arg Lys Gln Ser  Glu Ser Ser 
    1235                 1240                 1245             


Phe Ile  Xaa Gly Asp Ile Asn  Ser Ser Ala Ser Leu  Asn Arg Gly 
    1250                 1255                 1260             


Ala Met  Ala Asn His Leu Ile  Ser Asn Ala Leu Leu  Arg Pro His 
    1265                 1270                 1275             


Gly Xaa  Asn Asn Pro Tyr Asn  Xaa Leu Leu Gly Glu  Pro Ala Val 
    1280                 1285                 1290             


Cys Asn  Asn Pro Ser Val Ser  Met Tyr Asn Ala Gln  Glu Pro Tyr 
    1295                 1300                 1305             


Arg Glu  Xaa Ser Met Gly Val  Lys Leu Asn Ile Ala  Tyr Gln Ile 
    1310                 1315                 1320             


Gly Ala  Ser Glu Gln Cys Gln  Gly Tyr Lys Cys His  Gly Tyr Ser 
    1325                 1330                 1335             


Xaa Xaa  Glu Trp 
    1340         


<210> 1782
<211> 1351
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1208)..(1208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1260)..(1260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1320)..(1320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1349)
<223> Selenocysteine

<400> 1782
Met Trp Pro Ser Gln Leu Leu Ile Phe Met Met Leu Leu Ala Pro Ile 
1               5                   10                  15      


Ile His Gly Gly Lys His Ser Glu Arg His Pro Ala Leu Ala Ala Pro 
            20                  25                  30          


Leu Arg His Ala Glu Arg Ser Pro Gly Gly Ala Leu Pro Pro Arg His 
        35                  40                  45              


Leu Leu Gln Gln Pro Ala Ala Glu Arg Xaa Ala Ala His Arg Gly Gln 
    50                  55                  60                  


Gly Pro Arg Gly Ala Xaa Arg Gly Val Arg Gly Pro Gly Ala Gln Gly 
65                  70                  75                  80  


Ala Gln Ile Ala Ala Gln Ala Phe Ser Arg Ala Pro Ile Pro Met Ala 
                85                  90                  95      


Val Val Arg Arg Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg 
            100                 105                 110         


Cys Pro Gly Xaa Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg 
        115                 120                 125             


Xaa Asp Asp Lys Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile 
    130                 135                 140                 


Arg Cys Tyr Leu Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn 
145                 150                 155                 160 


Asn Arg Xaa Gln Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp 
                165                 170                 175     


Pro Cys Pro Gly Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val 
            180                 185                 190         


Pro Tyr Lys Val Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys 
        195                 200                 205             


Gly Val Tyr Gln Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly 
    210                 215                 220                 


Ala Trp Cys Lys Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met 
225                 230                 235                 240 


Pro Trp Xaa Pro Tyr Arg Xaa Asp Xaa Leu Xaa Glu Tyr Ser Ser Lys 
                245                 250                 255     


Asp Asp Phe Ile Ala Gly Arg Pro Xaa Xaa Xaa Tyr Lys Leu Pro His 
            260                 265                 270         


Arg Val Asp Gly Xaa Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe 
        275                 280                 285             


Asn Lys Glu Arg Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg 
    290                 295                 300                 


Ile Lys Ser Gly Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Xaa 
305                 310                 315                 320 


Ser Pro Tyr Arg Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp 
                325                 330                 335     


Glu Asn Gly Leu Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Lys 
            340                 345                 350         


Ile Val Ile Ser Gln Leu Asn Pro Tyr Xaa Leu Arg Ile Glu Gly Xaa 
        355                 360                 365             


Trp Asp Xaa Ala Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile 
    370                 375                 380                 


Cys Gly Ile Leu Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn 
385                 390                 395                 400 


Glu Ala Xaa Gly Asn Lys Ile Asp Tyr Ile Tyr Asn Xaa Asp Gln Ser 
                405                 410                 415     


Lys Asp Ser Leu Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile 
            420                 425                 430         


Ala Ala Val Asp Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn 
        435                 440                 445             


Asn Tyr His Val Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser 
    450                 455                 460                 


Arg Ser Gly Gln Ala His His Gly Gln Val Ser Tyr Ile Ser Pro Pro 
465                 470                 475                 480 


Ile His Leu Asp Ser Glu Leu Glu Arg Pro Ser Val Lys Asp Ile Ser 
                485                 490                 495     


Xaa Xaa Gly Pro Leu Gly Met Gly Ser Xaa Xaa Xaa Ser Xaa Xaa Leu 
            500                 505                 510         


Arg Xaa Xaa Xaa Leu Ser Pro Gly Arg Ser Xaa Xaa Pro Ser Val Ser 
        515                 520                 525             


Gly Arg Arg Asn Arg Ser Xaa Ser Xaa Pro Ser Pro Ala Val Glu Val 
    530                 535                 540                 


Leu Asp Asp Met Xaa Xaa His Leu Pro Ser Ala Ser Ser Gln Ile Pro 
545                 550                 555                 560 


Ala Leu Glu Glu Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp 
                565                 570                 575     


Phe Lys Xaa Arg Gln Gly Gln Ile Ala Lys Gln Pro Cys Pro Ala Gly 
            580                 585                 590         


Xaa Ile Gly Val Ser Xaa Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp 
        595                 600                 605             


Asp Pro Gln Gly Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn 
    610                 615                 620                 


His Ile Xaa Gln Lys Leu Lys Ser Gly Glu Xaa Ala Ala Asn Ile Ala 
625                 630                 635                 640 


Arg Glu Leu Ala Glu Gln Xaa Arg Asn His Leu Asn Ala Gly Asp Ile 
                645                 650                 655     


Xaa Tyr Ser Val Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val 
            660                 665                 670         


Gln Leu Arg Asn Leu Xaa Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser 
        675                 680                 685             


Leu Asn Lys Leu Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln 
    690                 695                 700                 


Ala Met Val Glu Xaa Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn 
705                 710                 715                 720 


Ala Trp Arg Asp Leu Xaa Xaa Ser Asp Gln Leu Arg Ala Ala Xaa Met 
                725                 730                 735     


Leu Leu His Xaa Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu 
            740                 745                 750         


Leu Lys Xaa Asp Ile Val Arg Glu Asn Xaa Asp Asn Ile Lys Leu Glu 
        755                 760                 765             


Val Ala Arg Leu Ser Xaa Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro 
    770                 775                 780                 


Glu Asn Met Gly His Gly Ser Xaa Ile Gln Leu Ser Ala Asn Xaa Leu 
785                 790                 795                 800 


Lys Gln Asn Gly Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr 
                805                 810                 815     


Asn Asn Leu Gly Pro Tyr Leu Ser Xaa Glu Asn Ala Ser Met Lys Leu 
            820                 825                 830         


Gly Xaa Glu Ala Leu Ser Xaa Asn His Ser Val Ile Val Asn Ser Pro 
        835                 840                 845             


Val Ile Xaa Ala Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu 
    850                 855                 860                 


Ala Asp Pro Val Val Phe Xaa Val Lys His Ile Lys Gln Ser Glu Glu 
865                 870                 875                 880 


Asn Phe Asn Pro Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Xaa Met 
                885                 890                 895     


Xaa Gly Tyr Trp Ser Xaa Gln Gly Cys Arg Leu Leu Xaa Xaa Asn Lys 
            900                 905                 910         


Xaa His Xaa Xaa Cys Ser Cys Asn His Leu Xaa Asn Phe Ala Val Leu 
        915                 920                 925             


Met Ala His Val Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu 
    930                 935                 940                 


Leu Asp Val Ile Xaa Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu 
945                 950                 955                 960 


Leu Ile Cys Ile Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp 
                965                 970                 975     


Arg Asn Xaa Ile His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu 
            980                 985                 990         


Leu Leu Phe Leu Ile Gly Ile Asn  Arg Xaa Asp Gln Pro  Ile Ala Cys 
        995                 1000                 1005             


Ala Val  Phe Ala Ala Leu Leu  His Phe Phe Phe Leu  Ala Ala Phe 
    1010                 1015                 1020             


Xaa Trp  Met Phe Leu Glu Gly  Val Gln Leu Tyr Ile  Met Leu Val 
    1025                 1030                 1035             


Glu Val  Phe Glu Ser Glu His  Ser Arg Arg Lys Tyr  Phe Tyr Leu 
    1040                 1045                 1050             


Val Gly  Tyr Gly Met Pro Ala  Leu Ile Val Ala Val  Ser Ala Ala 
    1055                 1060                 1065             


Val Asp  Tyr Arg Ser Tyr Gly  Xaa Asp Lys Val Cys  Trp Leu Arg 
    1070                 1075                 1080             


Leu Asp  Xaa Tyr Phe Ile Trp  Ser Phe Ile Gly Pro  Ala Xaa Leu 
    1085                 1090                 1095             


Ile Ile  Met Leu Asn Val Ile  Phe Leu Gly Ile Ala  Leu Tyr Lys 
    1100                 1105                 1110             


Met Phe  His His Xaa Ala Ile  Leu Lys Pro Glu Ser  Gly Cys Leu 
    1115                 1120                 1125             


Asp Asn  Ile Asn Tyr Glu Asp  Asn Arg Pro Phe Ile  Lys Ser Trp 
    1130                 1135                 1140             


Val Ile  Gly Ala Ile Ala Leu  Leu Cys Leu Leu Gly  Leu Xaa Trp 
    1145                 1150                 1155             


Ala Phe  Gly Leu Met Tyr Ile  Asn Glu Ser Xaa Val  Ile Met Ala 
    1160                 1165                 1170             


Tyr Leu  Phe Xaa Ile Phe Asn  Ser Leu Gln Gly Met  Phe Ile Phe 
    1175                 1180                 1185             


Ile Phe  His Cys Val Leu Gln  Lys Lys Val Arg Lys  Glu Tyr Gly 
    1190                 1195                 1200             


Lys Cys  Leu Arg Xaa His Cys  Cys Ser Gly Lys Ser  Xaa Glu Ser 
    1205                 1210                 1215             


Ser Ile  Gly Ser Gly Lys Xaa  Ser Gly Ser Arg Xaa  Pro Gly Arg 
    1220                 1225                 1230             


Tyr Ser  Xaa Gly Ser Gln Ser  Arg Ile Arg Arg Met  Trp Asn Asp 
    1235                 1240                 1245             


Xaa Val  Arg Lys Gln Ser Glu  Ser Ser Phe Ile Xaa  Gly Asp Ile 
    1250                 1255                 1260             


Asn Ser  Ser Ala Ser Leu Asn  Arg Gly Ala Met Ala  Asn His Leu 
    1265                 1270                 1275             


Ile Ser  Asn Ala Leu Leu Arg  Pro His Gly Xaa Asn  Asn Pro Tyr 
    1280                 1285                 1290             


Asn Xaa  Leu Leu Gly Glu Pro  Ala Val Cys Asn Asn  Pro Ser Val 
    1295                 1300                 1305             


Ser Met  Tyr Asn Ala Gln Glu  Pro Tyr Arg Glu Xaa  Ser Met Gly 
    1310                 1315                 1320             


Val Lys  Leu Asn Ile Ala Tyr  Gln Ile Gly Ala Ser  Glu Gln Cys 
    1325                 1330                 1335             


Gln Gly  Tyr Lys Cys His Gly  Tyr Ser Xaa Xaa Glu  Trp 
    1340                 1345                 1350     


<210> 1783
<211> 1528
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1221)..(1221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1240)..(1240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1272)..(1272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1277)..(1277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1323)..(1323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1367)..(1367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1396)..(1396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1405)..(1405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1422)..(1422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1426)..(1426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1439)..(1439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1443)..(1443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1454)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1459)..(1459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1491)..(1491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1512)..(1512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1526)..(1526)
<223> Selenocysteine

<400> 1783
Met Trp Pro Ser Gln Leu Leu Ile Phe Met Met Leu Leu Ala Pro Ile 
1               5                   10                  15      


Ile His Gly Gly Lys His Ser Glu Arg His Pro Ala Leu Ala Ala Pro 
            20                  25                  30          


Leu Arg His Ala Glu Arg Ser Pro Gly Gly Ala Leu Pro Pro Arg His 
        35                  40                  45              


Leu Leu Gln Gln Pro Ala Ala Glu Arg Xaa Ala Ala His Arg Gly Gln 
    50                  55                  60                  


Gly Pro Arg Gly Ala Xaa Arg Gly Val Arg Gly Pro Gly Ala Gln Gly 
65                  70                  75                  80  


Ala Gln Ile Ala Ala Gln Ala Phe Ser Arg Ala Pro Ile Pro Met Ala 
                85                  90                  95      


Val Val Arg Arg Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg 
            100                 105                 110         


Cys Pro Gly Xaa Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg 
        115                 120                 125             


Xaa Asp Asp Lys Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile 
    130                 135                 140                 


Arg Cys Tyr Leu Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn 
145                 150                 155                 160 


Asn Arg Xaa Gln Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp 
                165                 170                 175     


Pro Cys Pro Gly Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val 
            180                 185                 190         


Pro Tyr Lys Val Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys 
        195                 200                 205             


Gly Val Tyr Gln Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly 
    210                 215                 220                 


Ala Trp Cys Lys Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met 
225                 230                 235                 240 


Pro Trp Xaa Pro Tyr Arg Xaa Asp Xaa Leu Xaa Glu Tyr Ser Ser Lys 
                245                 250                 255     


Asp Asp Phe Ile Ala Gly Arg Pro Xaa Xaa Xaa Tyr Lys Leu Pro His 
            260                 265                 270         


Arg Val Asp Gly Xaa Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe 
        275                 280                 285             


Asn Lys Glu Arg Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg 
    290                 295                 300                 


Ile Lys Ser Gly Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Xaa 
305                 310                 315                 320 


Ser Pro Tyr Arg Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp 
                325                 330                 335     


Glu Asn Gly Leu Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Lys 
            340                 345                 350         


Ile Val Ile Ser Gln Leu Asn Pro Tyr Xaa Leu Arg Ile Glu Gly Xaa 
        355                 360                 365             


Trp Asp Xaa Ala Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile 
    370                 375                 380                 


Cys Gly Ile Leu Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn 
385                 390                 395                 400 


Glu Ala Xaa Gly Asn Lys Ile Asp Tyr Ile Tyr Asn Xaa Asp Gln Ser 
                405                 410                 415     


Lys Asp Ser Leu Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile 
            420                 425                 430         


Ala Ala Val Asp Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn 
        435                 440                 445             


Asn Tyr His Val Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser 
    450                 455                 460                 


Arg Ser Gly Gln Ala His His Gly Gln Val Ser Tyr Ile Ser Pro Pro 
465                 470                 475                 480 


Ile His Leu Asp Ser Glu Leu Glu Arg Pro Ser Val Lys Asp Ile Ser 
                485                 490                 495     


Xaa Xaa Gly Pro Leu Gly Met Gly Ser Xaa Xaa Xaa Ser Xaa Xaa Leu 
            500                 505                 510         


Arg Xaa Xaa Xaa Leu Ser Pro Gly Arg Ser Xaa Xaa Pro Ser Val Ser 
        515                 520                 525             


Gly Arg Arg Asn Arg Ser Xaa Ser Xaa Pro Ser Pro Ala Val Glu Val 
    530                 535                 540                 


Leu Asp Asp Met Xaa Xaa His Leu Pro Ser Ala Ser Ser Gln Ile Pro 
545                 550                 555                 560 


Ala Leu Glu Glu Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp 
                565                 570                 575     


Phe Lys Xaa Arg Gln Gly Gln Ile Ala Lys Gln Pro Cys Pro Ala Gly 
            580                 585                 590         


Xaa Ile Gly Val Ser Xaa Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp 
        595                 600                 605             


Asp Pro Gln Gly Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn 
    610                 615                 620                 


His Ile Xaa Gln Lys Leu Lys Ser Gly Glu Xaa Ala Ala Asn Ile Ala 
625                 630                 635                 640 


Arg Glu Leu Ala Glu Gln Xaa Arg Asn His Leu Asn Ala Gly Asp Ile 
                645                 650                 655     


Xaa Tyr Ser Val Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val 
            660                 665                 670         


Gln Leu Arg Asn Leu Xaa Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser 
        675                 680                 685             


Leu Asn Lys Leu Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln 
    690                 695                 700                 


Ala Met Val Glu Xaa Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn 
705                 710                 715                 720 


Ala Trp Arg Asp Leu Xaa Xaa Ser Asp Gln Leu Arg Ala Ala Xaa Met 
                725                 730                 735     


Leu Leu His Xaa Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu 
            740                 745                 750         


Leu Lys Xaa Asp Ile Val Arg Glu Asn Xaa Asp Asn Ile Lys Leu Glu 
        755                 760                 765             


Val Ala Arg Leu Ser Xaa Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro 
    770                 775                 780                 


Glu Asn Met Gly His Gly Ser Xaa Ile Gln Leu Ser Ala Asn Xaa Leu 
785                 790                 795                 800 


Lys Gln Asn Gly Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr 
                805                 810                 815     


Asn Asn Leu Gly Pro Tyr Leu Ser Xaa Glu Asn Ala Ser Met Lys Leu 
            820                 825                 830         


Gly Xaa Glu Ala Leu Ser Xaa Asn His Ser Val Ile Val Asn Ser Pro 
        835                 840                 845             


Val Ile Xaa Ala Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu 
    850                 855                 860                 


Ala Asp Pro Val Val Phe Xaa Val Lys His Ile Lys Gln Ser Glu Glu 
865                 870                 875                 880 


Asn Phe Asn Pro Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Xaa Met 
                885                 890                 895     


Xaa Gly Tyr Trp Ser Xaa Gln Gly Cys Arg Leu Leu Xaa Xaa Asn Lys 
            900                 905                 910         


Xaa His Xaa Xaa Cys Ser Cys Asn His Leu Xaa Asn Phe Ala Val Leu 
        915                 920                 925             


Met Ala His Val Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu 
    930                 935                 940                 


Leu Asp Val Ile Xaa Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu 
945                 950                 955                 960 


Leu Ile Cys Ile Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp 
                965                 970                 975     


Arg Asn Xaa Ile His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu 
            980                 985                 990         


Leu Leu Phe Leu Ile Gly Ile Asn  Arg Xaa Asp Gln Pro  Ile Ala Cys 
        995                 1000                 1005             


Ala Val  Phe Ala Ala Leu Leu  His Phe Phe Phe Leu  Ala Ala Phe 
    1010                 1015                 1020             


Xaa Trp  Met Phe Leu Glu Gly  Val Gln Leu Tyr Ile  Met Leu Val 
    1025                 1030                 1035             


Glu Val  Phe Glu Ser Glu His  Ser Arg Arg Lys Tyr  Phe Tyr Leu 
    1040                 1045                 1050             


Val Gly  Tyr Gly Met Pro Ala  Leu Ile Val Ala Val  Ser Ala Ala 
    1055                 1060                 1065             


Val Asp  Tyr Arg Ser Tyr Gly  Xaa Asp Lys Val Cys  Trp Leu Arg 
    1070                 1075                 1080             


Leu Asp  Xaa Tyr Phe Ile Trp  Ser Phe Ile Gly Pro  Ala Xaa Leu 
    1085                 1090                 1095             


Ile Ile  Met Leu Asn Val Ile  Phe Leu Gly Ile Ala  Leu Tyr Lys 
    1100                 1105                 1110             


Met Phe  His His Xaa Ala Ile  Leu Lys Pro Glu Ser  Gly Cys Leu 
    1115                 1120                 1125             


Asp Asn  Ile Lys Ser Trp Val  Ile Gly Ala Ile Ala  Leu Leu Cys 
    1130                 1135                 1140             


Leu Leu  Gly Leu Xaa Trp Ala  Phe Gly Leu Met Tyr  Ile Asn Glu 
    1145                 1150                 1155             


Ser Xaa  Val Ile Met Ala Tyr  Leu Phe Xaa Ile Phe  Asn Ser Leu 
    1160                 1165                 1170             


Gln Gly  Met Phe Ile Phe Ile  Phe His Cys Val Leu  Gln Lys Lys 
    1175                 1180                 1185             


Val Arg  Lys Glu Tyr Gly Lys  Cys Leu Arg Xaa His  Cys Cys Ser 
    1190                 1195                 1200             


Gly Lys  Ser Xaa Glu Ser Ser  Ile Gly Ser Gly Lys  Xaa Ser Gly 
    1205                 1210                 1215             


Ser Arg  Xaa Pro Gly Arg Tyr  Ser Xaa Gly Ser Gln  Ser Arg Ile 
    1220                 1225                 1230             


Arg Arg  Met Trp Asn Asp Xaa  Val Arg Lys Gln Ser  Glu Ser Ser 
    1235                 1240                 1245             


Phe Ile  Xaa Gly Asp Ile Asn  Ser Ser Ala Ser Leu  Asn Arg Glu 
    1250                 1255                 1260             


Gly Leu  Leu Asn Asn Ala Arg  Asp Xaa Ser Val Met  Asp Xaa Leu 
    1265                 1270                 1275             


Pro Leu  Asn Gly Asn His Gly  Asn Ser Tyr Ser Ile  Ala Ser Gly 
    1280                 1285                 1290             


Glu Tyr  Leu Ser Asn Cys Val  Gln Ile Ile Asp Arg  Gly Tyr Asn 
    1295                 1300                 1305             


His Asn  Glu Xaa Ala Leu Glu  Lys Lys Ile Leu Lys  Glu Leu Xaa 
    1310                 1315                 1320             


Ser Asn  Tyr Ile Pro Ser Tyr  Leu Asn Asn His Glu  Arg Ser Ser 
    1325                 1330                 1335             


Glu Gln  Asn Arg Asn Leu Met  Asn Lys Leu Val Asn  Asn Leu Gly 
    1340                 1345                 1350             


Ser Gly  Arg Glu Asp Asp Ala  Ile Val Leu Asp Asp  Ala Xaa Ser 
    1355                 1360                 1365             


Phe Asn  His Glu Glu Ser Leu  Gly Leu Glu Leu Ile  His Glu Glu 
    1370                 1375                 1380             


Ser Asp  Ala Pro Leu Leu Pro  Pro Arg Val Tyr Ser  Xaa Glu Asn 
    1385                 1390                 1395             


His Gln  Pro His His Tyr Xaa  Arg Arg Arg Ile Pro  Gln Asp His 
    1400                 1405                 1410             


Ser Glu  Ser Phe Phe Pro Leu  Leu Xaa Asn Glu His  Xaa Glu Asp 
    1415                 1420                 1425             


Leu Gln  Ser Pro His Arg Asp  Ser Leu Tyr Xaa Ser  Met Pro Xaa 
    1430                 1435                 1440             


Leu Ala  Gly Val Ala Ala Xaa  Glu Ser Val Xaa Xaa  Ser Xaa Gln 
    1445                 1450                 1455             


Xaa Glu  Pro Pro Pro Ala Lys  Cys Gly Asp Ala Glu  Asp Val Tyr 
    1460                 1465                 1470             


Tyr Lys  Ser Met Pro Asn Leu  Gly Ser Arg Asn His  Val His Gln 
    1475                 1480                 1485             


Leu His  Xaa Tyr Tyr Gln Leu  Gly Arg Gly Ser Ser  Asp Gly Phe 
    1490                 1495                 1500             


Ile Val  Pro Pro Asn Lys Asp  Gly Xaa Pro Pro Glu  Gly Ser Ser 
    1505                 1510                 1515             


Lys Gly  Pro Ala His Leu Val  Xaa Ser Leu 
    1520                 1525             


<210> 1784
<211> 1571
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1221)..(1221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1240)..(1240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1280)..(1280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1315)..(1315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1320)..(1320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1355)..(1355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1366)..(1366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1410)..(1410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1439)..(1439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1448)..(1448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1465)..(1465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1469)..(1469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1482)..(1482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1486)..(1486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1493)..(1493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1497)..(1498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1500)..(1500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1502)..(1502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1534)..(1534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1569)..(1569)
<223> Selenocysteine

<400> 1784
Met Trp Pro Ser Gln Leu Leu Ile Phe Met Met Leu Leu Ala Pro Ile 
1               5                   10                  15      


Ile His Gly Gly Lys His Ser Glu Arg His Pro Ala Leu Ala Ala Pro 
            20                  25                  30          


Leu Arg His Ala Glu Arg Ser Pro Gly Gly Ala Leu Pro Pro Arg His 
        35                  40                  45              


Leu Leu Gln Gln Pro Ala Ala Glu Arg Xaa Ala Ala His Arg Gly Gln 
    50                  55                  60                  


Gly Pro Arg Gly Ala Xaa Arg Gly Val Arg Gly Pro Gly Ala Gln Gly 
65                  70                  75                  80  


Ala Gln Ile Ala Ala Gln Ala Phe Ser Arg Ala Pro Ile Pro Met Ala 
                85                  90                  95      


Val Val Arg Arg Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg 
            100                 105                 110         


Cys Pro Gly Xaa Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg 
        115                 120                 125             


Xaa Asp Asp Lys Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile 
    130                 135                 140                 


Arg Cys Tyr Leu Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn 
145                 150                 155                 160 


Asn Arg Xaa Gln Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp 
                165                 170                 175     


Pro Cys Pro Gly Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val 
            180                 185                 190         


Pro Tyr Lys Val Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys 
        195                 200                 205             


Gly Val Tyr Gln Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly 
    210                 215                 220                 


Ala Trp Cys Lys Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met 
225                 230                 235                 240 


Pro Trp Xaa Pro Tyr Arg Xaa Asp Xaa Leu Xaa Glu Tyr Ser Ser Lys 
                245                 250                 255     


Asp Asp Phe Ile Ala Gly Arg Pro Xaa Xaa Xaa Tyr Lys Leu Pro His 
            260                 265                 270         


Arg Val Asp Gly Xaa Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe 
        275                 280                 285             


Asn Lys Glu Arg Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg 
    290                 295                 300                 


Ile Lys Ser Gly Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Xaa 
305                 310                 315                 320 


Ser Pro Tyr Arg Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp 
                325                 330                 335     


Glu Asn Gly Leu Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Lys 
            340                 345                 350         


Ile Val Ile Ser Gln Leu Asn Pro Tyr Xaa Leu Arg Ile Glu Gly Xaa 
        355                 360                 365             


Trp Asp Xaa Ala Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile 
    370                 375                 380                 


Cys Gly Ile Leu Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn 
385                 390                 395                 400 


Glu Ala Xaa Gly Asn Lys Ile Asp Tyr Ile Tyr Asn Xaa Asp Gln Ser 
                405                 410                 415     


Lys Asp Ser Leu Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile 
            420                 425                 430         


Ala Ala Val Asp Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn 
        435                 440                 445             


Asn Tyr His Val Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser 
    450                 455                 460                 


Arg Ser Gly Gln Ala His His Gly Gln Val Ser Tyr Ile Ser Pro Pro 
465                 470                 475                 480 


Ile His Leu Asp Ser Glu Leu Glu Arg Pro Ser Val Lys Asp Ile Ser 
                485                 490                 495     


Xaa Xaa Gly Pro Leu Gly Met Gly Ser Xaa Xaa Xaa Ser Xaa Xaa Leu 
            500                 505                 510         


Arg Xaa Xaa Xaa Leu Ser Pro Gly Arg Ser Xaa Xaa Pro Ser Val Ser 
        515                 520                 525             


Gly Arg Arg Asn Arg Ser Xaa Ser Xaa Pro Ser Pro Ala Val Glu Val 
    530                 535                 540                 


Leu Asp Asp Met Xaa Xaa His Leu Pro Ser Ala Ser Ser Gln Ile Pro 
545                 550                 555                 560 


Ala Leu Glu Glu Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp 
                565                 570                 575     


Phe Lys Xaa Arg Gln Gly Gln Ile Ala Lys Gln Pro Cys Pro Ala Gly 
            580                 585                 590         


Xaa Ile Gly Val Ser Xaa Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp 
        595                 600                 605             


Asp Pro Gln Gly Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn 
    610                 615                 620                 


His Ile Xaa Gln Lys Leu Lys Ser Gly Glu Xaa Ala Ala Asn Ile Ala 
625                 630                 635                 640 


Arg Glu Leu Ala Glu Gln Xaa Arg Asn His Leu Asn Ala Gly Asp Ile 
                645                 650                 655     


Xaa Tyr Ser Val Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val 
            660                 665                 670         


Gln Leu Arg Asn Leu Xaa Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser 
        675                 680                 685             


Leu Asn Lys Leu Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln 
    690                 695                 700                 


Ala Met Val Glu Xaa Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn 
705                 710                 715                 720 


Ala Trp Arg Asp Leu Xaa Xaa Ser Asp Gln Leu Arg Ala Ala Xaa Met 
                725                 730                 735     


Leu Leu His Xaa Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu 
            740                 745                 750         


Leu Lys Xaa Asp Ile Val Arg Glu Asn Xaa Asp Asn Ile Lys Leu Glu 
        755                 760                 765             


Val Ala Arg Leu Ser Xaa Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro 
    770                 775                 780                 


Glu Asn Met Gly His Gly Ser Xaa Ile Gln Leu Ser Ala Asn Xaa Leu 
785                 790                 795                 800 


Lys Gln Asn Gly Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr 
                805                 810                 815     


Asn Asn Leu Gly Pro Tyr Leu Ser Xaa Glu Asn Ala Ser Met Lys Leu 
            820                 825                 830         


Gly Xaa Glu Ala Leu Ser Xaa Asn His Ser Val Ile Val Asn Ser Pro 
        835                 840                 845             


Val Ile Xaa Ala Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu 
    850                 855                 860                 


Ala Asp Pro Val Val Phe Xaa Val Lys His Ile Lys Gln Ser Glu Glu 
865                 870                 875                 880 


Asn Phe Asn Pro Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Xaa Met 
                885                 890                 895     


Xaa Gly Tyr Trp Ser Xaa Gln Gly Cys Arg Leu Leu Xaa Xaa Asn Lys 
            900                 905                 910         


Xaa His Xaa Xaa Cys Ser Cys Asn His Leu Xaa Asn Phe Ala Val Leu 
        915                 920                 925             


Met Ala His Val Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu 
    930                 935                 940                 


Leu Asp Val Ile Xaa Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu 
945                 950                 955                 960 


Leu Ile Cys Ile Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp 
                965                 970                 975     


Arg Asn Xaa Ile His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu 
            980                 985                 990         


Leu Leu Phe Leu Ile Gly Ile Asn  Arg Xaa Asp Gln Pro  Ile Ala Cys 
        995                 1000                 1005             


Ala Val  Phe Ala Ala Leu Leu  His Phe Phe Phe Leu  Ala Ala Phe 
    1010                 1015                 1020             


Xaa Trp  Met Phe Leu Glu Gly  Val Gln Leu Tyr Ile  Met Leu Val 
    1025                 1030                 1035             


Glu Val  Phe Glu Ser Glu His  Ser Arg Arg Lys Tyr  Phe Tyr Leu 
    1040                 1045                 1050             


Val Gly  Tyr Gly Met Pro Ala  Leu Ile Val Ala Val  Ser Ala Ala 
    1055                 1060                 1065             


Val Asp  Tyr Arg Ser Tyr Gly  Xaa Asp Lys Val Cys  Trp Leu Arg 
    1070                 1075                 1080             


Leu Asp  Xaa Tyr Phe Ile Trp  Ser Phe Ile Gly Pro  Ala Xaa Leu 
    1085                 1090                 1095             


Ile Ile  Met Leu Asn Val Ile  Phe Leu Gly Ile Ala  Leu Tyr Lys 
    1100                 1105                 1110             


Met Phe  His His Xaa Ala Ile  Leu Lys Pro Glu Ser  Gly Cys Leu 
    1115                 1120                 1125             


Asp Asn  Ile Lys Ser Trp Val  Ile Gly Ala Ile Ala  Leu Leu Cys 
    1130                 1135                 1140             


Leu Leu  Gly Leu Xaa Trp Ala  Phe Gly Leu Met Tyr  Ile Asn Glu 
    1145                 1150                 1155             


Ser Xaa  Val Ile Met Ala Tyr  Leu Phe Xaa Ile Phe  Asn Ser Leu 
    1160                 1165                 1170             


Gln Gly  Met Phe Ile Phe Ile  Phe His Cys Val Leu  Gln Lys Lys 
    1175                 1180                 1185             


Val Arg  Lys Glu Tyr Gly Lys  Cys Leu Arg Xaa His  Cys Cys Ser 
    1190                 1195                 1200             


Gly Lys  Ser Xaa Glu Ser Ser  Ile Gly Ser Gly Lys  Xaa Ser Gly 
    1205                 1210                 1215             


Ser Arg  Xaa Pro Gly Arg Tyr  Ser Xaa Gly Ser Gln  Ser Arg Ile 
    1220                 1225                 1230             


Arg Arg  Met Trp Asn Asp Xaa  Val Arg Lys Gln Ser  Glu Ser Ser 
    1235                 1240                 1245             


Phe Ile  Xaa Gly Asp Ile Asn  Ser Ser Ala Ser Leu  Asn Arg Gly 
    1250                 1255                 1260             


Ala Met  Ala Asn His Leu Ile  Ser Asn Ala Leu Leu  Arg Pro His 
    1265                 1270                 1275             


Gly Xaa  Asn Asn Pro Tyr Asn  Xaa Leu Leu Gly Glu  Pro Ala Val 
    1280                 1285                 1290             


Cys Asn  Asn Pro Ser Val Ser  Met Tyr Asn Ala Gln  Glu Gly Leu 
    1295                 1300                 1305             


Leu Asn  Asn Ala Arg Asp Xaa  Ser Val Met Asp Xaa  Leu Pro Leu 
    1310                 1315                 1320             


Asn Gly  Asn His Gly Asn Ser  Tyr Ser Ile Ala Ser  Gly Glu Tyr 
    1325                 1330                 1335             


Leu Ser  Asn Cys Val Gln Ile  Ile Asp Arg Gly Tyr  Asn His Asn 
    1340                 1345                 1350             


Glu Xaa  Ala Leu Glu Lys Lys  Ile Leu Lys Glu Leu  Xaa Ser Asn 
    1355                 1360                 1365             


Tyr Ile  Pro Ser Tyr Leu Asn  Asn His Glu Arg Ser  Ser Glu Gln 
    1370                 1375                 1380             


Asn Arg  Asn Leu Met Asn Lys  Leu Val Asn Asn Leu  Gly Ser Gly 
    1385                 1390                 1395             


Arg Glu  Asp Asp Ala Ile Val  Leu Asp Asp Ala Xaa  Ser Phe Asn 
    1400                 1405                 1410             


His Glu  Glu Ser Leu Gly Leu  Glu Leu Ile His Glu  Glu Ser Asp 
    1415                 1420                 1425             


Ala Pro  Leu Leu Pro Pro Arg  Val Tyr Ser Xaa Glu  Asn His Gln 
    1430                 1435                 1440             


Pro His  His Tyr Xaa Arg Arg  Arg Ile Pro Gln Asp  His Ser Glu 
    1445                 1450                 1455             


Ser Phe  Phe Pro Leu Leu Xaa  Asn Glu His Xaa Glu  Asp Leu Gln 
    1460                 1465                 1470             


Ser Pro  His Arg Asp Ser Leu  Tyr Xaa Ser Met Pro  Xaa Leu Ala 
    1475                 1480                 1485             


Gly Val  Ala Ala Xaa Glu Ser  Val Xaa Xaa Ser Xaa  Gln Xaa Glu 
    1490                 1495                 1500             


Pro Pro  Pro Ala Lys Cys Gly  Asp Ala Glu Asp Val  Tyr Tyr Lys 
    1505                 1510                 1515             


Ser Met  Pro Asn Leu Gly Ser  Arg Asn His Val His  Gln Leu His 
    1520                 1525                 1530             


Xaa Tyr  Tyr Gln Leu Gly Arg  Gly Ser Ser Asp Gly  Phe Ile Val 
    1535                 1540                 1545             


Pro Pro  Asn Lys Asp Gly Xaa  Pro Pro Glu Gly Ser  Ser Lys Gly 
    1550                 1555                 1560             


Pro Ala  His Leu Val Xaa Ser  Leu 
    1565                 1570     


<210> 1785
<211> 1580
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1208)..(1208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1260)..(1260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1324)..(1324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1364)..(1364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1375)..(1375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1419)..(1419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1448)..(1448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1474)..(1474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1478)..(1478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1491)..(1491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1495)..(1495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1502)..(1502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1509)..(1509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1511)..(1511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1543)..(1543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1564)..(1564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1578)..(1578)
<223> Selenocysteine

<400> 1785
Met Trp Pro Ser Gln Leu Leu Ile Phe Met Met Leu Leu Ala Pro Ile 
1               5                   10                  15      


Ile His Gly Gly Lys His Ser Glu Arg His Pro Ala Leu Ala Ala Pro 
            20                  25                  30          


Leu Arg His Ala Glu Arg Ser Pro Gly Gly Ala Leu Pro Pro Arg His 
        35                  40                  45              


Leu Leu Gln Gln Pro Ala Ala Glu Arg Xaa Ala Ala His Arg Gly Gln 
    50                  55                  60                  


Gly Pro Arg Gly Ala Xaa Arg Gly Val Arg Gly Pro Gly Ala Gln Gly 
65                  70                  75                  80  


Ala Gln Ile Ala Ala Gln Ala Phe Ser Arg Ala Pro Ile Pro Met Ala 
                85                  90                  95      


Val Val Arg Arg Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg 
            100                 105                 110         


Cys Pro Gly Xaa Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg 
        115                 120                 125             


Xaa Asp Asp Lys Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile 
    130                 135                 140                 


Arg Cys Tyr Leu Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn 
145                 150                 155                 160 


Asn Arg Xaa Gln Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp 
                165                 170                 175     


Pro Cys Pro Gly Xaa Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val 
            180                 185                 190         


Pro Tyr Lys Val Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys 
        195                 200                 205             


Gly Val Tyr Gln Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly 
    210                 215                 220                 


Ala Trp Cys Lys Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met 
225                 230                 235                 240 


Pro Trp Xaa Pro Tyr Arg Xaa Asp Xaa Leu Xaa Glu Tyr Ser Ser Lys 
                245                 250                 255     


Asp Asp Phe Ile Ala Gly Arg Pro Xaa Xaa Xaa Tyr Lys Leu Pro His 
            260                 265                 270         


Arg Val Asp Gly Xaa Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe 
        275                 280                 285             


Asn Lys Glu Arg Xaa Arg Asn Ile Val Lys Phe Asp Leu Arg Xaa Arg 
    290                 295                 300                 


Ile Lys Ser Gly Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Xaa 
305                 310                 315                 320 


Ser Pro Tyr Arg Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp 
                325                 330                 335     


Glu Asn Gly Leu Trp Val Ile Tyr Ala Xaa Glu Gln Asn Asn Gly Lys 
            340                 345                 350         


Ile Val Ile Ser Gln Leu Asn Pro Tyr Xaa Leu Arg Ile Glu Gly Xaa 
        355                 360                 365             


Trp Asp Xaa Ala Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile 
    370                 375                 380                 


Cys Gly Ile Leu Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn 
385                 390                 395                 400 


Glu Ala Xaa Gly Asn Lys Ile Asp Tyr Ile Tyr Asn Xaa Asp Gln Ser 
                405                 410                 415     


Lys Asp Ser Leu Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile 
            420                 425                 430         


Ala Ala Val Asp Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn 
        435                 440                 445             


Asn Tyr His Val Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser 
    450                 455                 460                 


Arg Ser Gly Gln Ala His His Gly Gln Val Ser Tyr Ile Ser Pro Pro 
465                 470                 475                 480 


Ile His Leu Asp Ser Glu Leu Glu Arg Pro Ser Val Lys Asp Ile Ser 
                485                 490                 495     


Xaa Xaa Gly Pro Leu Gly Met Gly Ser Xaa Xaa Xaa Ser Xaa Xaa Leu 
            500                 505                 510         


Arg Xaa Xaa Xaa Leu Ser Pro Gly Arg Ser Xaa Xaa Pro Ser Val Ser 
        515                 520                 525             


Gly Arg Arg Asn Arg Ser Xaa Ser Xaa Pro Ser Pro Ala Val Glu Val 
    530                 535                 540                 


Leu Asp Asp Met Xaa Xaa His Leu Pro Ser Ala Ser Ser Gln Ile Pro 
545                 550                 555                 560 


Ala Leu Glu Glu Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp 
                565                 570                 575     


Phe Lys Xaa Arg Gln Gly Gln Ile Ala Lys Gln Pro Cys Pro Ala Gly 
            580                 585                 590         


Xaa Ile Gly Val Ser Xaa Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp 
        595                 600                 605             


Asp Pro Gln Gly Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn 
    610                 615                 620                 


His Ile Xaa Gln Lys Leu Lys Ser Gly Glu Xaa Ala Ala Asn Ile Ala 
625                 630                 635                 640 


Arg Glu Leu Ala Glu Gln Xaa Arg Asn His Leu Asn Ala Gly Asp Ile 
                645                 650                 655     


Xaa Tyr Ser Val Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val 
            660                 665                 670         


Gln Leu Arg Asn Leu Xaa Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser 
        675                 680                 685             


Leu Asn Lys Leu Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln 
    690                 695                 700                 


Ala Met Val Glu Xaa Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn 
705                 710                 715                 720 


Ala Trp Arg Asp Leu Xaa Xaa Ser Asp Gln Leu Arg Ala Ala Xaa Met 
                725                 730                 735     


Leu Leu His Xaa Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu 
            740                 745                 750         


Leu Lys Xaa Asp Ile Val Arg Glu Asn Xaa Asp Asn Ile Lys Leu Glu 
        755                 760                 765             


Val Ala Arg Leu Ser Xaa Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro 
    770                 775                 780                 


Glu Asn Met Gly His Gly Ser Xaa Ile Gln Leu Ser Ala Asn Xaa Leu 
785                 790                 795                 800 


Lys Gln Asn Gly Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr 
                805                 810                 815     


Asn Asn Leu Gly Pro Tyr Leu Ser Xaa Glu Asn Ala Ser Met Lys Leu 
            820                 825                 830         


Gly Xaa Glu Ala Leu Ser Xaa Asn His Ser Val Ile Val Asn Ser Pro 
        835                 840                 845             


Val Ile Xaa Ala Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu 
    850                 855                 860                 


Ala Asp Pro Val Val Phe Xaa Val Lys His Ile Lys Gln Ser Glu Glu 
865                 870                 875                 880 


Asn Phe Asn Pro Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Xaa Met 
                885                 890                 895     


Xaa Gly Tyr Trp Ser Xaa Gln Gly Cys Arg Leu Leu Xaa Xaa Asn Lys 
            900                 905                 910         


Xaa His Xaa Xaa Cys Ser Cys Asn His Leu Xaa Asn Phe Ala Val Leu 
        915                 920                 925             


Met Ala His Val Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu 
    930                 935                 940                 


Leu Asp Val Ile Xaa Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu 
945                 950                 955                 960 


Leu Ile Cys Ile Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp 
                965                 970                 975     


Arg Asn Xaa Ile His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu 
            980                 985                 990         


Leu Leu Phe Leu Ile Gly Ile Asn  Arg Xaa Asp Gln Pro  Ile Ala Cys 
        995                 1000                 1005             


Ala Val  Phe Ala Ala Leu Leu  His Phe Phe Phe Leu  Ala Ala Phe 
    1010                 1015                 1020             


Xaa Trp  Met Phe Leu Glu Gly  Val Gln Leu Tyr Ile  Met Leu Val 
    1025                 1030                 1035             


Glu Val  Phe Glu Ser Glu His  Ser Arg Arg Lys Tyr  Phe Tyr Leu 
    1040                 1045                 1050             


Val Gly  Tyr Gly Met Pro Ala  Leu Ile Val Ala Val  Ser Ala Ala 
    1055                 1060                 1065             


Val Asp  Tyr Arg Ser Tyr Gly  Xaa Asp Lys Val Cys  Trp Leu Arg 
    1070                 1075                 1080             


Leu Asp  Xaa Tyr Phe Ile Trp  Ser Phe Ile Gly Pro  Ala Xaa Leu 
    1085                 1090                 1095             


Ile Ile  Met Leu Asn Val Ile  Phe Leu Gly Ile Ala  Leu Tyr Lys 
    1100                 1105                 1110             


Met Phe  His His Xaa Ala Ile  Leu Lys Pro Glu Ser  Gly Cys Leu 
    1115                 1120                 1125             


Asp Asn  Ile Asn Tyr Glu Asp  Asn Arg Pro Phe Ile  Lys Ser Trp 
    1130                 1135                 1140             


Val Ile  Gly Ala Ile Ala Leu  Leu Cys Leu Leu Gly  Leu Xaa Trp 
    1145                 1150                 1155             


Ala Phe  Gly Leu Met Tyr Ile  Asn Glu Ser Xaa Val  Ile Met Ala 
    1160                 1165                 1170             


Tyr Leu  Phe Xaa Ile Phe Asn  Ser Leu Gln Gly Met  Phe Ile Phe 
    1175                 1180                 1185             


Ile Phe  His Cys Val Leu Gln  Lys Lys Val Arg Lys  Glu Tyr Gly 
    1190                 1195                 1200             


Lys Cys  Leu Arg Xaa His Cys  Cys Ser Gly Lys Ser  Xaa Glu Ser 
    1205                 1210                 1215             


Ser Ile  Gly Ser Gly Lys Xaa  Ser Gly Ser Arg Xaa  Pro Gly Arg 
    1220                 1225                 1230             


Tyr Ser  Xaa Gly Ser Gln Ser  Arg Ile Arg Arg Met  Trp Asn Asp 
    1235                 1240                 1245             


Xaa Val  Arg Lys Gln Ser Glu  Ser Ser Phe Ile Xaa  Gly Asp Ile 
    1250                 1255                 1260             


Asn Ser  Ser Ala Ser Leu Asn  Arg Gly Ala Met Ala  Asn His Leu 
    1265                 1270                 1275             


Ile Ser  Asn Ala Leu Leu Arg  Pro His Gly Xaa Asn  Asn Pro Tyr 
    1280                 1285                 1290             


Asn Xaa  Leu Leu Gly Glu Pro  Ala Val Cys Asn Asn  Pro Ser Val 
    1295                 1300                 1305             


Ser Met  Tyr Asn Ala Gln Glu  Gly Leu Leu Asn Asn  Ala Arg Asp 
    1310                 1315                 1320             


Xaa Ser  Val Met Asp Xaa Leu  Pro Leu Asn Gly Asn  His Gly Asn 
    1325                 1330                 1335             


Ser Tyr  Ser Ile Ala Ser Gly  Glu Tyr Leu Ser Asn  Cys Val Gln 
    1340                 1345                 1350             


Ile Ile  Asp Arg Gly Tyr Asn  His Asn Glu Xaa Ala  Leu Glu Lys 
    1355                 1360                 1365             


Lys Ile  Leu Lys Glu Leu Xaa  Ser Asn Tyr Ile Pro  Ser Tyr Leu 
    1370                 1375                 1380             


Asn Asn  His Glu Arg Ser Ser  Glu Gln Asn Arg Asn  Leu Met Asn 
    1385                 1390                 1395             


Lys Leu  Val Asn Asn Leu Gly  Ser Gly Arg Glu Asp  Asp Ala Ile 
    1400                 1405                 1410             


Val Leu  Asp Asp Ala Xaa Ser  Phe Asn His Glu Glu  Ser Leu Gly 
    1415                 1420                 1425             


Leu Glu  Leu Ile His Glu Glu  Ser Asp Ala Pro Leu  Leu Pro Pro 
    1430                 1435                 1440             


Arg Val  Tyr Ser Xaa Glu Asn  His Gln Pro His His  Tyr Xaa Arg 
    1445                 1450                 1455             


Arg Arg  Ile Pro Gln Asp His  Ser Glu Ser Phe Phe  Pro Leu Leu 
    1460                 1465                 1470             


Xaa Asn  Glu His Xaa Glu Asp  Leu Gln Ser Pro His  Arg Asp Ser 
    1475                 1480                 1485             


Leu Tyr  Xaa Ser Met Pro Xaa  Leu Ala Gly Val Ala  Ala Xaa Glu 
    1490                 1495                 1500             


Ser Val  Xaa Xaa Ser Xaa Gln  Xaa Glu Pro Pro Pro  Ala Lys Cys 
    1505                 1510                 1515             


Gly Asp  Ala Glu Asp Val Tyr  Tyr Lys Ser Met Pro  Asn Leu Gly 
    1520                 1525                 1530             


Ser Arg  Asn His Val His Gln  Leu His Xaa Tyr Tyr  Gln Leu Gly 
    1535                 1540                 1545             


Arg Gly  Ser Ser Asp Gly Phe  Ile Val Pro Pro Asn  Lys Asp Gly 
    1550                 1555                 1560             


Xaa Pro  Pro Glu Gly Ser Ser  Lys Gly Pro Ala His  Leu Val Xaa 
    1565                 1570                 1575             


Ser Leu  
    1580 


<210> 1786
<211> 918
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<400> 1786
Xaa Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp Asp Pro Gln Gly Pro 
1               5                   10                  15      


Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn His Ile Xaa Gln Lys 
            20                  25                  30          


Leu Lys Ser Gly Glu Xaa Ala Ala Asn Ile Ala Arg Glu Leu Ala Glu 
        35                  40                  45              


Gln Xaa Arg Asn His Leu Asn Ala Gly Asp Ile Xaa Tyr Ser Val Arg 
    50                  55                  60                  


Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val Gln Leu Arg Asn Leu 
65                  70                  75                  80  


Xaa Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser Leu Asn Lys Ala Met 
                85                  90                  95      


Val Glu Xaa Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn Ala Trp 
            100                 105                 110         


Arg Asp Leu Xaa Xaa Ser Asp Gln Leu Arg Ala Ala Xaa Met Leu Leu 
        115                 120                 125             


His Xaa Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu Leu Lys 
    130                 135                 140                 


Xaa Asp Ile Val Arg Glu Asn Xaa Asp Asn Ile Lys Leu Glu Val Ala 
145                 150                 155                 160 


Arg Leu Ser Xaa Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro Glu Asn 
                165                 170                 175     


Met Gly His Gly Ser Xaa Ile Gln Leu Ser Ala Asn Xaa Leu Lys Gln 
            180                 185                 190         


Asn Gly Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr Asn Asn 
        195                 200                 205             


Leu Gly Pro Tyr Leu Ser Xaa Glu Asn Ala Ser Met Lys Leu Gly Xaa 
    210                 215                 220                 


Glu Ala Leu Ser Xaa Asn His Ser Val Ile Val Asn Ser Pro Val Ile 
225                 230                 235                 240 


Xaa Ala Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu Ala Asp 
                245                 250                 255     


Pro Val Val Phe Xaa Val Lys His Ile Lys Gln Ser Glu Glu Asn Phe 
            260                 265                 270         


Asn Pro Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Xaa Met Xaa Gly 
        275                 280                 285             


Tyr Trp Ser Xaa Gln Gly Cys Arg Leu Leu Xaa Xaa Asn Lys Xaa His 
    290                 295                 300                 


Xaa Xaa Cys Ser Cys Asn His Leu Xaa Asn Phe Ala Val Leu Met Ala 
305                 310                 315                 320 


His Val Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu Leu Asp 
                325                 330                 335     


Val Ile Xaa Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu Leu Ile 
            340                 345                 350         


Cys Ile Phe Xaa Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn 
        355                 360                 365             


Xaa Ile His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu Leu Leu 
    370                 375                 380                 


Phe Leu Ile Gly Ile Asn Arg Xaa Asp Gln Pro Ile Ala Cys Ala Val 
385                 390                 395                 400 


Phe Ala Ala Leu Leu His Phe Phe Phe Leu Ala Ala Phe Xaa Trp Met 
                405                 410                 415     


Phe Leu Glu Gly Val Gln Leu Tyr Ile Met Leu Val Glu Val Phe Glu 
            420                 425                 430         


Ser Glu His Ser Arg Arg Lys Tyr Phe Tyr Leu Val Gly Tyr Gly Met 
        435                 440                 445             


Pro Ala Leu Ile Val Ala Val Ser Ala Ala Val Asp Tyr Arg Ser Tyr 
    450                 455                 460                 


Gly Xaa Asp Lys Val Cys Trp Leu Arg Leu Asp Xaa Tyr Phe Ile Trp 
465                 470                 475                 480 


Ser Phe Ile Gly Pro Ala Xaa Leu Ile Ile Met Leu Asn Val Ile Phe 
                485                 490                 495     


Leu Gly Ile Ala Leu Tyr Lys Met Phe His His Xaa Ala Ile Leu Lys 
            500                 505                 510         


Pro Glu Ser Gly Cys Leu Asp Asn Ile Lys Ser Trp Val Ile Gly Ala 
        515                 520                 525             


Ile Ala Leu Leu Cys Leu Leu Gly Leu Xaa Trp Ala Phe Gly Leu Met 
    530                 535                 540                 


Tyr Ile Asn Glu Ser Xaa Val Ile Met Ala Tyr Leu Phe Xaa Ile Phe 
545                 550                 555                 560 


Asn Ser Leu Gln Gly Met Phe Ile Phe Ile Phe His Cys Val Leu Gln 
                565                 570                 575     


Lys Lys Val Arg Lys Glu Tyr Gly Lys Cys Leu Arg Xaa His Cys Cys 
            580                 585                 590         


Ser Gly Lys Ser Xaa Glu Ser Ser Ile Gly Ser Gly Lys Xaa Ser Gly 
        595                 600                 605             


Ser Arg Xaa Pro Gly Arg Tyr Ser Xaa Gly Ser Gln Ser Arg Ile Arg 
    610                 615                 620                 


Arg Met Trp Asn Asp Xaa Val Arg Lys Gln Ser Glu Ser Ser Phe Ile 
625                 630                 635                 640 


Xaa Gly Asp Ile Asn Ser Ser Ala Ser Leu Asn Arg Glu Gly Leu Leu 
                645                 650                 655     


Asn Asn Ala Arg Asp Xaa Ser Val Met Asp Xaa Leu Pro Leu Asn Gly 
            660                 665                 670         


Asn His Gly Asn Ser Tyr Ser Ile Ala Ser Gly Glu Tyr Leu Ser Asn 
        675                 680                 685             


Cys Val Gln Ile Ile Asp Arg Gly Tyr Asn His Asn Glu Xaa Ala Leu 
    690                 695                 700                 


Glu Lys Lys Ile Leu Lys Glu Leu Xaa Ser Asn Tyr Ile Pro Ser Tyr 
705                 710                 715                 720 


Leu Asn Asn His Glu Arg Ser Ser Glu Gln Asn Arg Asn Leu Met Asn 
                725                 730                 735     


Lys Leu Val Asn Asn Leu Gly Ser Gly Arg Glu Asp Asp Ala Ile Val 
            740                 745                 750         


Leu Asp Asp Ala Xaa Ser Phe Asn His Glu Glu Ser Leu Gly Leu Glu 
        755                 760                 765             


Leu Ile His Glu Glu Ser Asp Ala Pro Leu Leu Pro Pro Arg Val Tyr 
    770                 775                 780                 


Ser Xaa Glu Asn His Gln Pro His His Tyr Xaa Arg Arg Arg Ile Pro 
785                 790                 795                 800 


Gln Asp His Ser Glu Ser Phe Phe Pro Leu Leu Xaa Asn Glu His Xaa 
                805                 810                 815     


Glu Asp Leu Gln Ser Pro His Arg Asp Ser Leu Tyr Xaa Ser Met Pro 
            820                 825                 830         


Xaa Leu Ala Gly Val Ala Ala Xaa Glu Ser Val Xaa Xaa Ser Xaa Gln 
        835                 840                 845             


Xaa Glu Pro Pro Pro Ala Lys Cys Gly Asp Ala Glu Asp Val Tyr Tyr 
    850                 855                 860                 


Lys Ser Met Pro Asn Leu Gly Ser Arg Asn His Val His Gln Leu His 
865                 870                 875                 880 


Xaa Tyr Tyr Gln Leu Gly Arg Gly Ser Ser Asp Gly Phe Ile Val Pro 
                885                 890                 895     


Pro Asn Lys Asp Gly Xaa Pro Pro Glu Gly Ser Ser Lys Gly Pro Ala 
            900                 905                 910         


His Leu Val Xaa Ser Leu 
        915             


<210> 1787
<211> 690
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<400> 1787
Met Lys Arg Leu Pro Leu Leu Val Val Phe Ser Xaa Leu Leu Asn Cys 
1               5                   10                  15      


Ser Tyr Xaa Gln Asn Cys Xaa Lys Xaa Pro Cys Leu Pro Asn Ala Lys 
            20                  25                  30          


Cys Glu Ile Arg Asn Gly Ile Glu Ala Cys Tyr Cys Asn Met Gly Phe 
        35                  40                  45              


Ser Gly Asn Gly Val Xaa Ile Cys Glu Asp Asp Asn Glu Cys Gly Asn 
    50                  55                  60                  


Leu Xaa Gln Ser Cys Gly Glu Asn Ala Asn Cys Xaa Asn Xaa Glu Gly 
65                  70                  75                  80  


Ser Tyr Tyr Cys Met Cys Val Pro Gly Phe Arg Ser Ser Ser Asn Gln 
                85                  90                  95      


Asp Arg Phe Ile Xaa Asn Asp Gly Xaa Val Cys Ile Glu Asn Val Asn 
            100                 105                 110         


Ala Asn Cys His Leu Asp Asn Val Cys Ile Ala Ala Asn Ile Asn Lys 
        115                 120                 125             


Xaa Leu Xaa Lys Ile Arg Ser Ile Lys Glu Pro Val Ala Leu Leu Gln 
    130                 135                 140                 


Glu Val Tyr Arg Asn Ser Val Xaa Asp Leu Ser Pro Xaa Asp Ile Ile 
145                 150                 155                 160 


Xaa Tyr Ile Glu Ile Leu Ala Glu Ser Ser Ser Leu Leu Gly Tyr Lys 
                165                 170                 175     


Asn Asn Xaa Ile Ser Ala Lys Asp Xaa Leu Ser Asn Ser Xaa Leu Xaa 
            180                 185                 190         


Glu Phe Val Lys Xaa Val Asn Asn Phe Val Gln Arg Asp Xaa Phe Val 
        195                 200                 205             


Val Trp Asp Lys Leu Ser Val Asn His Arg Arg Xaa His Leu Xaa Lys 
    210                 215                 220                 


Leu Met His Xaa Val Glu Gln Ala Xaa Leu Arg Ile Ser Gln Ser Phe 
225                 230                 235                 240 


Gln Lys Xaa Xaa Glu Phe Asp Xaa Asn Ser Xaa Asp Ile Ala Leu Lys 
                245                 250                 255     


Val Phe Phe Phe Asp Ser Tyr Asn Met Lys His Ile His Pro His Met 
            260                 265                 270         


Asn Met Asp Gly Asp Tyr Ile Asn Ile Phe Pro Lys Arg Lys Ala Ala 
        275                 280                 285             


Tyr Asp Ser Asn Gly Asn Val Ala Val Ala Phe Val Tyr Tyr Lys Ser 
    290                 295                 300                 


Ile Gly Pro Leu Leu Ser Ser Ser Asp Asn Phe Leu Leu Lys Pro Gln 
305                 310                 315                 320 


Asn Tyr Asp Asn Ser Glu Glu Glu Glu Arg Val Ile Ser Ser Val Ile 
                325                 330                 335     


Ser Val Ser Met Ser Ser Asn Pro Pro Xaa Leu Tyr Glu Leu Glu Lys 
            340                 345                 350         


Ile Xaa Phe Xaa Leu Ser His Arg Lys Val Xaa Asp Arg Tyr Arg Ser 
        355                 360                 365             


Leu Cys Ala Phe Trp Asn Tyr Ser Pro Asp Xaa Met Asn Gly Ser Trp 
    370                 375                 380                 


Ser Ser Glu Gly Cys Glu Leu Xaa Tyr Ser Asn Glu Xaa His Xaa Ser 
385                 390                 395                 400 


Cys Arg Cys Asn His Leu Xaa His Phe Ala Ile Leu Met Ser Ser Gly 
                405                 410                 415     


Pro Ser Ile Gly Ile Lys Asp Tyr Asn Ile Leu Xaa Arg Ile Xaa Gln 
            420                 425                 430         


Leu Gly Ile Ile Ile Ser Leu Ile Cys Leu Ala Ile Cys Ile Phe Xaa 
        435                 440                 445             


Phe Trp Phe Phe Ser Glu Ile Gln Ser Xaa Arg Xaa Xaa Ile His Lys 
    450                 455                 460                 


Asn Leu Cys Cys Ser Leu Phe Leu Ala Glu Leu Val Phe Leu Val Gly 
465                 470                 475                 480 


Ile Asn Xaa Asn Xaa Asn Lys Leu Phe Cys Ser Ile Ile Ala Gly Leu 
                485                 490                 495     


Leu His Tyr Phe Phe Leu Ala Ala Phe Ala Trp Met Cys Ile Glu Gly 
            500                 505                 510         


Ile His Leu Tyr Leu Ile Val Val Gly Val Ile Tyr Asn Lys Gly Phe 
        515                 520                 525             


Leu His Lys Asn Phe Tyr Ile Phe Gly Tyr Leu Ser Pro Ala Val Val 
    530                 535                 540                 


Val Gly Phe Ser Ala Ala Leu Gly Tyr Arg Tyr Tyr Gly Xaa Xaa Lys 
545                 550                 555                 560 


Val Cys Trp Leu Ser Xaa Glu Asn Asn Phe Ile Trp Ser Phe Ile Gly 
                565                 570                 575     


Pro Ala Cys Leu Ile Ile Leu Val Asn Leu Leu Ala Phe Gly Val Ile 
            580                 585                 590         


Ile Tyr Lys Val Phe Arg His Xaa Ala Gly Leu Lys Pro Glu Val Ser 
        595                 600                 605             


Cys Phe Glu Asn Ile Arg Ser Cys Ala Arg Gly Ala Leu Ala Leu Leu 
    610                 615                 620                 


Phe Leu Leu Gly Xaa Xaa Trp Ile Phe Gly Val Leu His Val Val His 
625                 630                 635                 640 


Ala Ser Val Val Xaa Ala Tyr Leu Phe Xaa Val Ser Asn Ala Phe Gln 
                645                 650                 655     


Gly Met Phe Ile Phe Leu Phe Leu Cys Val Leu Ser Arg Lys Ile Gln 
            660                 665                 670         


Glu Glu Tyr Tyr Arg Leu Phe Lys Asn Val Pro Cys Cys Phe Gly Cys 
        675                 680                 685             


Leu Arg 
    690 


<210> 1788
<211> 149
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<400> 1788
Val Val Val Gly Phe Ser Ala Ala Leu Gly Tyr Arg Tyr Tyr Gly Xaa 
1               5                   10                  15      


Xaa Lys Val Cys Trp Leu Ser Xaa Glu Asn Asn Phe Ile Trp Ser Phe 
            20                  25                  30          


Ile Gly Pro Ala Cys Leu Ile Ile Leu Val Asn Leu Leu Ala Phe Gly 
        35                  40                  45              


Val Ile Ile Tyr Lys Val Phe Arg His Xaa Ala Gly Leu Lys Pro Glu 
    50                  55                  60                  


Val Ser Cys Phe Glu Asn Ile Arg Ser Cys Ala Arg Gly Ala Leu Ala 
65                  70                  75                  80  


Leu Leu Phe Leu Leu Gly Xaa Xaa Trp Ile Phe Gly Val Leu His Val 
                85                  90                  95      


Val His Ala Ser Val Val Xaa Ala Tyr Leu Phe Xaa Val Ser Asn Ala 
            100                 105                 110         


Phe Gln Gly Met Phe Ile Phe Leu Phe Leu Cys Val Leu Ser Arg Lys 
        115                 120                 125             


Ile Gln Glu Glu Tyr Tyr Arg Leu Phe Lys Asn Val Pro Cys Cys Phe 
    130                 135                 140                 


Gly Cys Leu Ser Cys 
145                 


<210> 1789
<211> 148
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<400> 1789
Met Ala Lys Arg Ser Ala Ala Ala Ala Val Pro Gly Met Pro Ser Ala 
1               5                   10                  15      


Ser Leu Leu Val Asn Leu Leu Ser Ala Leu Leu Ile Leu Phe Val Phe 
            20                  25                  30          


Gly Glu Xaa Glu Ile Arg Phe Xaa Gly Gln Xaa Glu Phe Val Val Asn 
        35                  40                  45              


Glu Xaa Ser Xaa Xaa Val Ile Arg Leu Ile Ile Glu Arg Ile Gly Glu 
    50                  55                  60                  


Pro Ala Asn Val Xaa Ala Ile Val Ser Leu Tyr Gly Glu Asp Ala Gly 
65                  70                  75                  80  


Asp Phe Phe Asp Xaa Tyr Ala Ala Ala Phe Ile Pro Ala Gly Glu Xaa 
                85                  90                  95      


Asn Arg Xaa Val Tyr Ile Ala Val Cys Asp Asp Asp Leu Pro Glu Pro 
            100                 105                 110         


Asp Glu Xaa Phe Ile Phe His Leu Xaa Leu Gln Leu Pro Ser Ile Ala 
        115                 120                 125             


Val Ser Glu Pro Lys Gly Arg Asn Glu Ser Met Pro Leu Xaa Leu Ile 
    130                 135                 140                 


Arg Glu Lys Gly 
145             


<210> 1790
<211> 1967
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1105)..(1105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1187)..(1187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1197)..(1197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1226)..(1226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1243)..(1243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1246)..(1246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1321)..(1321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1367)..(1367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1377)..(1377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1386)..(1386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1399)..(1399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1452)..(1452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1459)..(1459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1475)..(1475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1494)..(1494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1514)..(1514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1540)..(1540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1560)..(1560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1572)..(1572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1603)..(1603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1612)..(1612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1638)..(1638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1667)..(1667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1724)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1731)..(1731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1779)..(1779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1829)..(1829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1840)..(1840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1844)..(1844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1860)..(1860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1898)..(1898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1928)..(1928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1948)..(1948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1950)..(1950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1965)..(1965)
<223> Selenocysteine

<400> 1790
Met Gln Leu Cys Ile Phe Cys Cys Cys Cys Ile Leu Phe Tyr Phe Asp 
1               5                   10                  15      


Leu Tyr Asp Phe Gly Arg Gly Tyr Asp Phe Xaa Ile Gln Glu Asn Gly 
            20                  25                  30          


Leu Gln Ile Asp Gln Pro Pro Glu Ile Gly Asn Ile Ser Ile Val Arg 
        35                  40                  45              


Ile Ile Ile Met Lys Asn Asp Asn Ala Glu Gly Ile Ile Glu Phe Asp 
    50                  55                  60                  


Pro Lys Tyr Xaa Ala Phe Glu Val Glu Glu Asp Val Gly Leu Ile Met 
65                  70                  75                  80  


Ile Pro Val Val Arg Leu His Gly Xaa Tyr Gly Tyr Val Xaa Ala Asp 
                85                  90                  95      


Phe Ile Ser Gln Ser Ser Ser Ala Ser Pro Gly Gly Val Asp Tyr Ile 
            100                 105                 110         


Leu His Gly Ser Xaa Val Xaa Phe Gln His Gly Gln Asn Leu Ser Phe 
        115                 120                 125             


Ile Asn Ile Ser Ile Ile Asp Asp Asn Glu Ser Glu Phe Glu Glu Pro 
    130                 135                 140                 


Ile Glu Ile Leu Leu Xaa Gly Ala Xaa Gly Gly Ala Val Leu Gly Arg 
145                 150                 155                 160 


His Leu Val Ser Arg Ile Ile Ile Ala Lys Ser Asp Ser Pro Phe Gly 
                165                 170                 175     


Val Ile Arg Phe Leu Asn Gln Ser Lys Ile Ser Ile Ala Asn Pro Asn 
            180                 185                 190         


Ser Xaa Met Ile Leu Ser Leu Val Leu Glu Arg Xaa Gly Gly Leu Leu 
        195                 200                 205             


Gly Glu Ile Gln Val Asn Trp Glu Xaa Val Gly Pro Asn Ser Gln Glu 
    210                 215                 220                 


Ala Leu Leu Pro Gln Asn Arg Asp Ile Ala Asp Pro Val Ser Gly Leu 
225                 230                 235                 240 


Phe Tyr Phe Gly Glu Gly Glu Gly Gly Val Arg Xaa Ile Ile Leu Xaa 
                245                 250                 255     


Ile Tyr Pro His Glu Glu Ile Glu Val Glu Glu Xaa Phe Ile Ile Lys 
            260                 265                 270         


Leu His Leu Val Lys Gly Glu Ala Lys Leu Asp Ser Arg Ala Lys Asp 
        275                 280                 285             


Val Xaa Leu Xaa Ile Gln Glu Phe Gly Asp Pro Asn Gly Val Val Gln 
    290                 295                 300                 


Phe Ala Pro Glu Xaa Leu Ser Lys Lys Xaa Tyr Ser Glu Pro Leu Ala 
305                 310                 315                 320 


Leu Glu Gly Pro Leu Leu Ile Xaa Phe Phe Val Arg Arg Val Lys Gly 
                325                 330                 335     


Xaa Phe Gly Glu Ile Met Val Tyr Trp Glu Leu Ser Ser Glu Phe Asp 
            340                 345                 350         


Ile Xaa Glu Asp Phe Leu Ser Xaa Ser Gly Phe Phe Xaa Ile Ala Asp 
        355                 360                 365             


Gly Glu Ser Glu Ala Ser Phe Asp Val His Leu Leu Pro Asp Glu Val 
    370                 375                 380                 


Pro Glu Ile Glu Glu Asp Tyr Val Ile Gln Leu Val Ser Val Glu Gly 
385                 390                 395                 400 


Gly Ala Glu Leu Asp Leu Glu Lys Ser Ile Xaa Trp Phe Ser Val Tyr 
                405                 410                 415     


Ala Asn Asp Asp Pro His Gly Val Phe Ala Leu Tyr Ser Asp Arg Gln 
            420                 425                 430         


Ser Ile Leu Ile Gly Gln Asn Leu Ile Arg Ser Ile Gln Ile Asn Ile 
        435                 440                 445             


Xaa Arg Leu Ala Gly Xaa Phe Gly Asp Val Ala Val Gly Leu Arg Ile 
    450                 455                 460                 


Ser Ser Asp His Lys Glu Gln Pro Ile Val Xaa Glu Asn Ala Glu Arg 
465                 470                 475                 480 


Gln Leu Val Val Lys Asp Gly Ala Xaa Tyr Lys Val Asp Val Val Pro 
                485                 490                 495     


Ile Lys Asn Gln Val Phe Leu Ser Leu Gly Ser Asn Phe Xaa Leu Gln 
            500                 505                 510         


Leu Val Xaa Val Met Leu Val Gly Gly Arg Phe Tyr Gly Met Pro Xaa 
        515                 520                 525             


Ile Leu Gln Glu Ala Lys Ser Ala Val Leu Pro Val Ser Glu Lys Ala 
    530                 535                 540                 


Ala Asn Ser Gln Val Gly Phe Glu Ser Xaa Ala Phe Gln Leu Met Asn 
545                 550                 555                 560 


Ile Xaa Ala Gly Xaa Ser His Val Met Ile Ser Arg Arg Gly Xaa Tyr 
                565                 570                 575     


Gly Ala Leu Ser Val Ala Trp Xaa Xaa Gly Tyr Ala Pro Gly Leu Glu 
            580                 585                 590         


Ile Pro Glu Phe Ile Val Val Gly Asn Met Xaa Pro Xaa Leu Gly Ser 
        595                 600                 605             


Leu Ser Phe Ser His Gly Glu Gln Arg Lys Gly Val Phe Leu Trp Xaa 
    610                 615                 620                 


Phe Pro Ser Pro Gly Trp Pro Glu Ala Phe Val Leu His Leu Ser Gly 
625                 630                 635                 640 


Val Gln Ser Ser Ala Pro Gly Gly Ala Gln Leu Arg Ser Gly Phe Ile 
                645                 650                 655     


Val Ala Glu Ile Glu Pro Met Gly Val Phe Gln Phe Ser Xaa Ser Ser 
            660                 665                 670         


Arg Asn Ile Ile Val Ser Glu Asp Xaa Gln Met Ile Arg Leu His Val 
        675                 680                 685             


Gln Arg Leu Phe Gly Phe His Ser Asp Leu Ile Lys Val Ser Tyr Gln 
    690                 695                 700                 


Xaa Xaa Ala Gly Ser Ala Lys Pro Leu Glu Asp Phe Glu Pro Val Gln 
705                 710                 715                 720 


Asn Gly Glu Leu Phe Phe Gln Lys Phe Gln Xaa Glu Val Asp Phe Glu 
                725                 730                 735     


Ile Xaa Ile Ile Asn Asp Gln Leu Ser Glu Ile Glu Glu Phe Phe Tyr 
            740                 745                 750         


Ile Asn Leu Xaa Ser Val Glu Ile Arg Gly Leu Gln Lys Phe Asp Val 
        755                 760                 765             


Asn Trp Ser Pro Arg Leu Asn Leu Asp Phe Ser Val Ala Val Ile Xaa 
    770                 775                 780                 


Ile Leu Asp Asn Asp Asp Leu Ala Gly Met Asp Ile Ser Phe Pro Glu 
785                 790                 795                 800 


Xaa Xaa Val Ala Val Ala Val Asp Xaa Xaa Leu Ile Pro Val Glu Xaa 
                805                 810                 815     


Glu Ser Xaa Xaa Tyr Leu Ser Xaa Ser Lys Xaa Xaa Xaa Ile Leu Gln 
            820                 825                 830         


Pro Xaa Asn Val Val Ala Ile Val Xaa Glu Ala Xaa Gly Val Ser Ala 
        835                 840                 845             


Ile Pro Glu Lys Leu Val Xaa Leu His Gly Xaa Pro Ala Val Ser Glu 
    850                 855                 860                 


Lys Pro Asp Val Ala Xaa Val Xaa Ala Asn Val Ser Ile His Gly Xaa 
865                 870                 875                 880 


Phe Ser Leu Gly Pro Ser Ile Val Tyr Ile Glu Glu Glu Met Lys Asn 
                885                 890                 895     


Gly Xaa Phe Asn Xaa Ala Glu Val Leu Ile Arg Arg Xaa Gly Gly Phe 
            900                 905                 910         


Xaa Gly Asn Val Ser Ile Xaa Val Lys Xaa Phe Gly Glu Arg Cys Ala 
        915                 920                 925             


Gln Met Glu Pro Asn Ala Leu Pro Phe Arg Gly Ile Tyr Gly Ile Ser 
    930                 935                 940                 


Asn Leu Xaa Trp Ala Val Glu Glu Glu Asp Phe Glu Glu Gln Xaa Leu 
945                 950                 955                 960 


Xaa Leu Ile Phe Leu Asp Gly Glu Arg Glu Arg Lys Val Ser Val Gln 
                965                 970                 975     


Ile Leu Asp Asp Asp Glu Pro Glu Gly Gln Glu Phe Phe Tyr Val Phe 
            980                 985                 990         


Leu Xaa Asn Pro Gln Gly Gly Ala  Gln Ile Val Glu Glu  Lys Asp Asp 
        995                 1000                 1005             


Xaa Gly  Phe Ala Ala Phe Ala  Met Val Ile Ile Xaa  Gly Ser Asp 
    1010                 1015                 1020             


Leu His  Asn Gly Ile Ile Gly  Phe Ser Glu Glu Ser  Gln Ser Gly 
    1025                 1030                 1035             


Leu Glu  Leu Arg Glu Gly Ala  Val Met Arg Arg Leu  His Leu Ile 
    1040                 1045                 1050             


Val Xaa  Arg Gln Pro Asn Arg  Ala Phe Glu Asp Val  Lys Val Phe 
    1055                 1060                 1065             


Trp Arg  Val Xaa Leu Asn Lys  Xaa Val Val Val Leu  Gln Lys Asp 
    1070                 1075                 1080             


Gly Val  Asn Leu Val Glu Glu  Leu Gln Ser Val Ser  Gly Xaa Xaa 
    1085                 1090                 1095             


Xaa Cys  Xaa Met Gly Gln Xaa  Lys Cys Phe Ile Ser  Ile Glu Leu 
    1100                 1105                 1110             


Lys Pro  Glu Lys Val Pro Gln  Val Glu Val Tyr Phe  Phe Val Glu 
    1115                 1120                 1125             


Leu Tyr  Glu Ala Xaa Ala Gly  Ala Ala Ile Asn Asn  Ser Ala Arg 
    1130                 1135                 1140             


Phe Ala  Gln Ile Lys Ile Leu  Glu Ser Asp Glu Ser  Gln Ser Leu 
    1145                 1150                 1155             


Val Tyr  Phe Ser Val Gly Ser  Arg Leu Ala Val Ala  His Lys Lys 
    1160                 1165                 1170             


Ala Xaa  Leu Ile Ser Leu Gln  Val Ala Arg Asp Ser  Gly Xaa Gly 
    1175                 1180                 1185             


Leu Met  Met Ser Val Asn Phe  Ser Xaa Gln Glu Leu  Arg Ser Ala 
    1190                 1195                 1200             


Glu Xaa  Ile Gly Arg Xaa Ile  Ile Ser Pro Ala Ile  Ser Gly Lys 
    1205                 1210                 1215             


Asp Phe  Val Ile Xaa Glu Gly  Xaa Leu Val Phe Glu  Pro Gly Gln 
    1220                 1225                 1230             


Arg Ser  Xaa Val Leu Asp Val  Ile Leu Xaa Pro Glu  Xaa Gly Ser 
    1235                 1240                 1245             


Leu Asn  Ser Phe Pro Lys Arg  Phe Gln Ile Val Leu  Phe Asp Pro 
    1250                 1255                 1260             


Lys Gly  Gly Ala Arg Ile Asp  Lys Val Tyr Gly Xaa  Ala Asn Ile 
    1265                 1270                 1275             


Xaa Leu  Val Ser Asp Ala Asp  Ser Gln Ala Ile Trp  Gly Leu Ala 
    1280                 1285                 1290             


Asp Gln  Leu His Gln Pro Val  Asn Asp Asp Ile Leu  Asn Arg Val 
    1295                 1300                 1305             


Leu His  Xaa Ile Ser Met Lys  Val Ala Xaa Glu Asn  Xaa Asp Glu 
    1310                 1315                 1320             


Gln Leu  Ser Ala Met Met His  Leu Ile Glu Lys Ile  Xaa Xaa Glu 
    1325                 1330                 1335             


Gly Lys  Ile Gln Ala Phe Ser  Val Ala Ser Arg Xaa  Leu Phe Tyr 
    1340                 1345                 1350             


Glu Ile  Leu Cys Ser Leu Ile  Asn Pro Lys Arg Lys  Asp Xaa Arg 
    1355                 1360                 1365             


Gly Phe  Ser His Phe Ala Glu  Val Xaa Glu Asn Phe  Ala Phe Ser 
    1370                 1375                 1380             


Leu Leu  Xaa Asn Val Xaa Cys  Gly Ser Pro Gly Glu  Lys Ser Lys 
    1385                 1390                 1395             


Xaa Ile  Leu Asp Ser Cys Pro  Tyr Leu Ser Ile Leu  Ala Leu His 
    1400                 1405                 1410             


Trp Tyr  Pro Gln Gln Ile Asn  Gly His Lys Phe Glu  Gly Lys Glu 
    1415                 1420                 1425             


Gly Asp  Tyr Ile Arg Ile Pro  Glu Arg Leu Leu Asp  Val Gln Asp 
    1430                 1435                 1440             


Ala Glu  Ile Met Ala Gly Lys  Ser Xaa Cys Lys Leu  Val Gln Phe 
    1445                 1450                 1455             


Xaa Glu  Tyr Ser Ser Gln Gln  Trp Phe Ile Ser Gly  Asn Asn Leu 
    1460                 1465                 1470             


Pro Xaa  Leu Lys Asn Lys Val  Leu Ser Leu Ser Val  Lys Gly Gln 
    1475                 1480                 1485             


Ser Ser  Gln Leu Leu Xaa Asn  Asp Asn Glu Val Leu  Tyr Arg Ile 
    1490                 1495                 1500             


Tyr Ala  Ala Glu Pro Arg Ile  Ile Pro Gln Xaa Ser  Leu Cys Leu 
    1505                 1510                 1515             


Leu Trp  Asn Gln Ala Ala Ala  Ser Trp Leu Ser Asp  Ser Gln Phe 
    1520                 1525                 1530             


Cys Lys  Val Val Glu Glu Xaa  Ala Asp Tyr Val Glu  Cys Ala Cys 
    1535                 1540                 1545             


Ser His  Met Ser Val Tyr Ala  Val Tyr Ala Arg Xaa  Asp Asn Leu 
    1550                 1555                 1560             


Ser Ser  Tyr Asn Glu Ala Phe  Phe Xaa Ser Gly Phe  Ile Cys Ile 
    1565                 1570                 1575             


Ser Gly  Leu Cys Leu Ala Val  Leu Ser His Ile Phe  Cys Ala Arg 
    1580                 1585                 1590             


Tyr Ser  Met Phe Ala Ala Lys  Leu Leu Xaa His Met  Met Ala Ala 
    1595                 1600                 1605             


Ser Leu  Gly Xaa Gln Ile Leu  Phe Leu Ala Ser Ala  Tyr Ala Ser 
    1610                 1615                 1620             


Pro Gln  Leu Ala Glu Glu Ser  Cys Ser Ala Met Ala  Ala Val Xaa 
    1625                 1630                 1635             


His Tyr  Leu Tyr Leu Cys Gln  Phe Ser Trp Met Leu  Ile Gln Ser 
    1640                 1645                 1650             


Val Asn  Phe Trp Tyr Val Leu  Val Met Asn Asp Glu  His Xaa Glu 
    1655                 1660                 1665             


Arg Arg  Tyr Leu Leu Phe Phe  Leu Leu Ser Trp Gly  Leu Pro Ala 
    1670                 1675                 1680             


Phe Val  Val Ile Leu Leu Ile  Val Ile Leu Lys Gly  Ile Tyr His 
    1685                 1690                 1695             


Gln Ser  Met Ser Gln Ile Tyr  Gly Leu Ile His Gly  Asp Leu Cys 
    1700                 1705                 1710             


Phe Ile  Pro Asn Val Tyr Ala  Ala Leu Phe Xaa Ala  Ala Leu Val 
    1715                 1720                 1725             


Pro Leu  Xaa Cys Leu Val Val  Val Phe Val Val Phe  Ile His Ala 
    1730                 1735                 1740             


Tyr Gln  Val Lys Pro Gln Trp  Lys Ala Tyr Asp Asp  Val Phe Arg 
    1745                 1750                 1755             


Gly Arg  Xaa Asn Ala Ala Glu  Ile Pro Leu Ile Leu  Tyr Leu Phe 
    1760                 1765                 1770             


Ala Leu  Ile Ser Val Xaa Trp  Leu Trp Gly Gly Leu  His Met Ala 
    1775                 1780                 1785             


Tyr Arg  His Phe Trp Met Leu  Val Leu Phe Val Ile  Phe Asn Ser 
    1790                 1795                 1800             


Leu Gln  Gly Leu Tyr Val Phe  Met Val Tyr Phe Ile  Leu His Asn 
    1805                 1810                 1815             


Gln Met  Cys Cys Pro Met Lys  Ala Ser Tyr Xaa Val  Glu Met Asn 
    1820                 1825                 1830             


Gly His  Pro Gly Pro Ser Xaa  Ala Phe Phe Xaa Pro  Gly Ser Gly 
    1835                 1840                 1845             


Met Pro  Pro Ala Gly Gly Glu  Ile Ser Lys Ser Xaa  Gln Asn Leu 
    1850                 1855                 1860             


Ile Gly  Ala Met Glu Glu Val  Pro Pro Asp Trp Glu  Arg Ala Ser 
    1865                 1870                 1875             


Phe Gln  Gln Gly Ser Gln Ala  Ser Pro Asp Leu Lys  Pro Ser Pro 
    1880                 1885                 1890             


Gln Asn  Gly Ala Xaa Phe Pro  Ser Ser Gly Gly Tyr  Gly Gln Gly 
    1895                 1900                 1905             


Ser Leu  Ile Ala Asp Glu Glu  Ser Gln Glu Phe Asp  Asp Leu Ile 
    1910                 1915                 1920             


Phe Ala  Leu Lys Xaa Gly Ala  Gly Leu Ser Val Ser  Asp Asn Glu 
    1925                 1930                 1935             


Ser Gly  Gln Gly Ser Gln Glu  Gly Gly Xaa Leu Xaa  Asp Ser Gln 
    1940                 1945                 1950             


Ile Val  Glu Leu Arg Arg Ile  Pro Ile Ala Asp Xaa  His Leu 
    1955                 1960                 1965         


<210> 1791
<211> 6306
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1108)..(1108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1224)..(1224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1267)..(1267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1270)..(1270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1325)..(1325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1339)..(1339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1356)..(1356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1367)..(1367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1395)..(1395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1402)..(1402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1413)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1477)..(1477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1491)..(1491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1521)..(1521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1559)..(1560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1564)..(1564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1578)..(1578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1591)..(1591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1599)..(1599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1611)..(1611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1617)..(1617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1635)..(1635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1664)..(1664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1678)..(1678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1680)..(1680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1691)..(1692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1695)..(1695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1710)..(1710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1731)..(1731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1759)..(1759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1763)..(1763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1776)..(1776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1793)..(1793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1837)..(1837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1853)..(1853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1876)..(1876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1884)..(1884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1886)..(1886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1895)..(1895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1900)..(1900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1916)..(1916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1921)..(1921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1927)..(1927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1932)..(1932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1966)..(1966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1968)..(1968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1994)..(1994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1998)..(1998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2017)..(2017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2035)..(2035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2057)..(2057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2082)..(2082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2104)..(2104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2119)..(2119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2141)..(2141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2143)..(2143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2160)..(2160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2181)..(2181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2209)..(2210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2219)..(2219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2240)..(2240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2264)..(2264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2269)..(2269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2275)..(2275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2282)..(2282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2293)..(2293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2299)..(2299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2302)..(2302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2324)..(2324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2331)..(2331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2351)..(2351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2374)..(2374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2391)..(2391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2425)..(2425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2438)..(2438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2441)..(2441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2467)..(2467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2481)..(2481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2487)..(2487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2507)..(2507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2523)..(2523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2559)..(2559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2567)..(2567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2589)..(2589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2604)..(2604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2613)..(2613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2630)..(2630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2632)..(2632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2645)..(2645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2651)..(2651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2654)..(2654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2658)..(2658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2678)..(2678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2690)..(2690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2709)..(2709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2729)..(2729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2737)..(2737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2767)..(2768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2794)..(2794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2815)..(2815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2843)..(2843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2861)..(2861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2863)..(2864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2875)..(2875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2900)..(2900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2907)..(2907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2925)..(2925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2930)..(2930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2935)..(2935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2947)..(2947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2974)..(2974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2979)..(2979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3012)..(3012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3048)..(3048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3060)..(3060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3090)..(3090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3114)..(3114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3116)..(3116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3122)..(3122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3134)..(3134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3159)..(3159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3170)..(3170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3175)..(3175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3186)..(3186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3189)..(3189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3210)..(3210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3220)..(3220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3228)..(3228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3241)..(3241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3245)..(3245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3274)..(3274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3290)..(3290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3311)..(3311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3326)..(3326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3342)..(3342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3344)..(3344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3354)..(3354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3367)..(3367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3386)..(3386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3409)..(3409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3453)..(3454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3511)..(3511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3555)..(3555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3604)..(3604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3613)..(3613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3641)..(3641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3643)..(3643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3675)..(3675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3684)..(3684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3689)..(3689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3704)..(3704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3711)..(3711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3718)..(3718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3720)..(3720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3722)..(3722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3738)..(3738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3740)..(3740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3743)..(3744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3755)..(3755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3766)..(3767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3795)..(3797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3831)..(3831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3841)..(3841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3873)..(3873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3875)..(3875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3886)..(3886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3918)..(3918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3926)..(3926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3982)..(3982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3988)..(3988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3998)..(3998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4000)..(4000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4021)..(4021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4040)..(4040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4057)..(4057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4059)..(4059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4069)..(4069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4075)..(4075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4090)..(4090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4096)..(4096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4101)..(4101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4106)..(4106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4110)..(4110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4119)..(4119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4172)..(4172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4188)..(4188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4204)..(4204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4209)..(4209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4240)..(4240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4254)..(4254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4258)..(4258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4287)..(4287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4304)..(4304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4308)..(4308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4352)..(4352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4354)..(4354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4366)..(4366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4407)..(4407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4428)..(4428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4433)..(4433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4456)..(4456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4458)..(4458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4489)..(4489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4492)..(4492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4533)..(4533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4543)..(4543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4556)..(4556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4591)..(4591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4595)..(4595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4607)..(4607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4629)..(4629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4631)..(4631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4648)..(4648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4653)..(4653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4667)..(4667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4676)..(4676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4693)..(4693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4699)..(4699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4704)..(4704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4750)..(4750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4788)..(4788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4793)..(4793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4814)..(4814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4828)..(4828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4849)..(4849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4854)..(4854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4867)..(4867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4893)..(4893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4901)..(4901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4904)..(4904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4914)..(4914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4923)..(4924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4942)..(4942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4944)..(4944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4963)..(4963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5009)..(5009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5020)..(5020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5044)..(5045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5070)..(5070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5077)..(5077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5095)..(5095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5123)..(5123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5140)..(5141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5148)..(5149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5155)..(5155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5158)..(5159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5163)..(5163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5166)..(5168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5173)..(5173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5180)..(5180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5183)..(5183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5194)..(5194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5198)..(5198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5209)..(5209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5211)..(5211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5219)..(5219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5237)..(5237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5240)..(5240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5248)..(5248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5252)..(5252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5258)..(5258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5261)..(5261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5286)..(5286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5298)..(5298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5300)..(5300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5333)..(5333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5348)..(5348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5359)..(5359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5394)..(5394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5411)..(5411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5415)..(5415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5436)..(5438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5440)..(5440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5444)..(5444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5472)..(5472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5514)..(5514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5526)..(5526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5536)..(5536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5544)..(5544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5548)..(5548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5562)..(5562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5565)..(5565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5575)..(5575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5582)..(5582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5585)..(5585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5614)..(5614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5618)..(5618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5650)..(5650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5657)..(5657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5660)..(5660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5675)..(5676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5689)..(5689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5706)..(5706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5716)..(5716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5725)..(5725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5728)..(5728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5738)..(5738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5791)..(5791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5798)..(5798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5814)..(5814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5833)..(5833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5853)..(5853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5879)..(5879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5899)..(5899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5911)..(5911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5942)..(5942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5951)..(5951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5977)..(5977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6006)..(6006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6063)..(6063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6070)..(6070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6100)..(6100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6118)..(6118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6168)..(6168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6179)..(6179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6183)..(6183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6199)..(6199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6237)..(6237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6267)..(6267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6287)..(6287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6289)..(6289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6304)..(6304)
<223> Selenocysteine

<400> 1791
Met Ser Val Phe Leu Gly Pro Gly Met Pro Ser Ala Ser Leu Leu Val 
1               5                   10                  15      


Asn Leu Leu Ser Ala Leu Leu Ile Leu Phe Val Phe Gly Glu Xaa Glu 
            20                  25                  30          


Ile Arg Phe Xaa Gly Gln Xaa Glu Phe Val Val Asn Glu Xaa Ser Xaa 
        35                  40                  45              


Xaa Val Ile Arg Leu Ile Ile Glu Arg Ile Gly Glu Pro Ala Asn Val 
    50                  55                  60                  


Xaa Ala Ile Val Ser Leu Tyr Gly Glu Asp Ala Gly Asp Phe Phe Asp 
65                  70                  75                  80  


Xaa Tyr Ala Ala Ala Phe Ile Pro Ala Gly Glu Xaa Asn Arg Xaa Val 
                85                  90                  95      


Tyr Ile Ala Val Cys Asp Asp Asp Leu Pro Glu Pro Asp Glu Xaa Phe 
            100                 105                 110         


Ile Phe His Leu Xaa Leu Gln Lys Pro Ser Ala Asn Val Lys Leu Gly 
        115                 120                 125             


Trp Pro Arg Xaa Val Xaa Val Xaa Ile Leu Ser Asn Asp Asn Ala Phe 
    130                 135                 140                 


Gly Ile Ile Ser Phe Asn Met Leu Pro Ser Ile Ala Val Ser Glu Pro 
145                 150                 155                 160 


Lys Gly Arg Asn Glu Ser Met Pro Leu Xaa Leu Ile Arg Glu Lys Gly 
                165                 170                 175     


Xaa Tyr Gly Met Val Met Val Xaa Phe Glu Val Glu Gly Gly Pro Asn 
            180                 185                 190         


Pro Pro Asp Glu Asp Leu Ser Pro Val Lys Gly Asn Ile Xaa Phe Pro 
        195                 200                 205             


Pro Gly Arg Ala Xaa Val Ile Tyr Asn Leu Xaa Val Leu Asp Asp Glu 
    210                 215                 220                 


Val Pro Glu Asn Asp Glu Ile Phe Leu Ile Gln Leu Lys Ser Val Glu 
225                 230                 235                 240 


Gly Gly Ala Glu Ile Asn Xaa Ser Arg Asn Ser Ile Glu Ile Ile Ile 
                245                 250                 255     


Lys Lys Asn Asp Ser Pro Val Arg Phe Leu Gln Ser Ile Tyr Leu Val 
            260                 265                 270         


Pro Glu Glu Asp His Ile Leu Ile Ile Pro Val Val Arg Gly Lys Asp 
        275                 280                 285             


Asn Asn Gly Asn Leu Ile Gly Ser Asp Glu Tyr Glu Val Ser Ile Ser 
    290                 295                 300                 


Tyr Ala Val Xaa Xaa Gly Asn Ser Xaa Ala His Ala Gln Gln Asn Leu 
305                 310                 315                 320 


Asp Phe Ile Asp Leu Gln Pro Asn Xaa Xaa Val Val Phe Pro Pro Phe 
                325                 330                 335     


Ile His Glu Ser His Leu Lys Phe Gln Ile Val Asp Asp Xaa Ile Pro 
            340                 345                 350         


Glu Ile Ala Glu Ser Phe His Ile Met Leu Leu Lys Asp Xaa Leu Gln 
        355                 360                 365             


Gly Asp Ala Val Leu Ile Ser Pro Ser Val Val Gln Val Xaa Ile Lys 
    370                 375                 380                 


Pro Asn Asp Lys Pro Tyr Gly Val Leu Ser Phe Asn Ser Val Leu Phe 
385                 390                 395                 400 


Glu Arg Xaa Val Ile Ile Asp Glu Asp Arg Ile Ser Arg Tyr Glu Glu 
                405                 410                 415     


Ile Xaa Val Val Arg Asn Gly Gly Xaa His Gly Asn Val Ser Ala Asn 
            420                 425                 430         


Trp Val Leu Xaa Arg Asn Ser Xaa Asp Pro Ser Pro Val Xaa Ala Asp 
        435                 440                 445             


Ile Arg Pro Ser Ser Gly Val Leu His Phe Ala Gln Gly Gln Met Leu 
    450                 455                 460                 


Ala Xaa Ile Pro Leu Xaa Val Val Asp Asp Asp Leu Pro Glu Glu Ala 
465                 470                 475                 480 


Glu Ala Tyr Leu Leu Gln Ile Leu Pro His Xaa Ile Arg Gly Gly Ala 
                485                 490                 495     


Glu Val Ser Glu Pro Ala Glu Leu Leu Phe Tyr Ile Gln Asp Ser Asp 
            500                 505                 510         


Asp Val Tyr Gly Leu Ile Xaa Phe Phe Pro Met Glu Asn Gln Lys Ile 
        515                 520                 525             


Glu Ser Ser Pro Gly Glu Arg Tyr Leu Ser Leu Ser Phe Xaa Arg Leu 
    530                 535                 540                 


Gly Gly Xaa Lys Gly Asp Val Arg Leu Leu Tyr Ser Val Leu Tyr Ile 
545                 550                 555                 560 


Pro Ala Gly Ala Val Asp Pro Leu Gln Ala Lys Glu Gly Ile Leu Asn 
                565                 570                 575     


Ile Ser Arg Arg Asn Asp Leu Ile Phe Pro Glu Gln Lys Xaa Gln Val 
            580                 585                 590         


Xaa Xaa Lys Leu Pro Ile Arg Asn Asp Ala Phe Leu Gln Asn Gly Ala 
        595                 600                 605             


His Phe Leu Val Gln Leu Glu Xaa Val Glu Leu Leu Asn Ile Ile Pro 
    610                 615                 620                 


Leu Ile Pro Pro Ile Ser Pro Arg Phe Gly Glu Ile Cys Asn Ile Ser 
625                 630                 635                 640 


Leu Leu Val Xaa Pro Ala Ile Ala Asn Gly Glu Ile Gly Phe Leu Ser 
                645                 650                 655     


Asn Leu Pro Ile Ile Leu His Glu Pro Glu Asp Phe Ala Ala Glu Val 
            660                 665                 670         


Val Tyr Ile Pro Leu His Arg Asp Gly Xaa Asp Gly Gln Ala Xaa Val 
        675                 680                 685             


Tyr Trp Ser Leu Lys Pro Ser Gly Phe Asn Ser Lys Ala Val Xaa Pro 
    690                 695                 700                 


Asp Asp Ile Gly Pro Phe Asn Gly Ser Val Leu Phe Leu Ser Gly Gln 
705                 710                 715                 720 


Ser Asp Xaa Xaa Ile Asn Ile Xaa Ile Lys Gly Asp Asp Ile Pro Glu 
                725                 730                 735     


Met Asn Glu Xaa Val Xaa Leu Ser Leu Asp Arg Val Asn Val Glu Asn 
            740                 745                 750         


Gln Val Leu Lys Ser Gly Tyr Xaa Ser Arg Asp Leu Ile Ile Leu Glu 
        755                 760                 765             


Asn Asp Asp Pro Gly Gly Val Phe Glu Phe Ser Pro Ala Ser Arg Gly 
    770                 775                 780                 


Pro Tyr Val Ile Lys Glu Gly Glu Ser Val Glu Leu His Ile Ile Arg 
785                 790                 795                 800 


Ser Arg Gly Ser Leu Val Lys Gln Phe Leu His Tyr Arg Val Glu Pro 
                805                 810                 815     


Arg Asp Ser Asn Glu Phe Tyr Gly Asn Xaa Gly Val Leu Glu Phe Lys 
            820                 825                 830         


Pro Gly Glu Arg Glu Ile Val Ile Xaa Leu Leu Ala Arg Leu Asp Gly 
        835                 840                 845             


Ile Pro Glu Leu Asp Glu His Tyr Trp Val Val Leu Ser Ser His Gly 
    850                 855                 860                 


Glu Arg Glu Ser Lys Leu Gly Ser Ala Xaa Ile Val Asn Ile Xaa Ile 
865                 870                 875                 880 


Leu Lys Asn Asp Asp Pro His Gly Ile Ile Glu Phe Val Ser Asp Gly 
                885                 890                 895     


Leu Ile Val Met Ile Asn Glu Ser Lys Gly Asp Ala Ile Tyr Ser Ala 
            900                 905                 910         


Val Tyr Asp Val Val Arg Asn Arg Gly Asn Phe Gly Asp Val Ser Val 
        915                 920                 925             


Ser Trp Val Val Ser Pro Asp Phe Xaa Gln Asp Val Phe Pro Val Gln 
    930                 935                 940                 


Gly Xaa Val Val Phe Gly Asp Gln Glu Phe Ser Lys Asn Ile Xaa Ile 
945                 950                 955                 960 


Tyr Ser Leu Pro Asp Glu Ile Pro Glu Glu Met Glu Glu Phe Xaa Val 
                965                 970                 975     


Ile Leu Leu Asn Gly Xaa Gly Gly Ala Lys Val Gly Asn Arg Xaa Xaa 
            980                 985                 990         


Ala Xaa Leu Arg Ile Arg Arg Asn  Asp Asp Pro Ile Tyr  Phe Ala Glu 
        995                 1000                 1005             


Pro Arg  Val Val Arg Val Gln  Glu Gly Glu Xaa Ala  Asn Phe Xaa 
    1010                 1015                 1020             


Val Leu  Arg Asn Gly Ser Val  Asp Val Xaa Cys Met  Val Gln Tyr 
    1025                 1030                 1035             


Ala Xaa  Lys Asp Gly Lys Ala  Xaa Ala Arg Glu Arg  Asp Phe Ile 
    1040                 1045                 1050             


Pro Val  Glu Lys Gly Glu Xaa  Leu Ile Phe Glu Val  Gly Ser Arg 
    1055                 1060                 1065             


Gln Gln  Ser Ile Ser Ile Phe  Val Asn Glu Asp Gly  Ile Pro Glu 
    1070                 1075                 1080             


Xaa Asp  Glu Pro Phe Tyr Ile  Ile Leu Leu Asn Ser  Xaa Gly Asp 
    1085                 1090                 1095             


Xaa Val  Val Tyr Gln Tyr Gly  Val Ala Xaa Val Ile  Ile Glu Ala 
    1100                 1105                 1110             


Asn Asp  Asp Pro Asn Gly Ile  Phe Ser Leu Glu Pro  Ile Asp Lys 
    1115                 1120                 1125             


Ala Val  Glu Glu Gly Lys Xaa  Asn Ala Phe Trp Ile  Leu Arg His 
    1130                 1135                 1140             


Arg Gly  Tyr Phe Gly Ser Val  Ser Val Ser Trp Gln  Leu Phe Gln 
    1145                 1150                 1155             


Asn Asp  Ser Ala Leu Gln Pro  Gly Gln Glu Phe Tyr  Glu Xaa Ser 
    1160                 1165                 1170             


Gly Xaa  Val Asn Phe Met Asp  Gly Glu Glu Ala Lys  Pro Ile Ile 
    1175                 1180                 1185             


Leu His  Ala Phe Pro Asp Lys  Ile Pro Glu Phe Asn  Glu Phe Tyr 
    1190                 1195                 1200             


Phe Leu  Lys Leu Val Asn Ile  Ser Gly Gly Ser Pro  Gly Pro Gly 
    1205                 1210                 1215             


Gly Gln  Leu Ala Glu Xaa Asn  Leu Gln Val Xaa Val  Met Val Pro 
    1220                 1225                 1230             


Phe Asn  Asp Asp Pro Phe Gly  Val Phe Ile Leu Asp  Pro Glu Cys 
    1235                 1240                 1245             


Leu Glu  Arg Glu Val Ala Glu  Asp Val Leu Ser Glu  Asp Asp Met 
    1250                 1255                 1260             


Ser Tyr  Ile Xaa Asn Phe Xaa  Ile Leu Arg Gln Gln  Gly Val Phe 
    1265                 1270                 1275             


Gly Asp  Val Gln Leu Gly Trp  Glu Ile Leu Ser Ser  Glu Phe Pro 
    1280                 1285                 1290             


Ala Gly  Leu Pro Pro Met Ile  Asp Phe Leu Leu Val  Gly Ile Phe 
    1295                 1300                 1305             


Pro Xaa  Xaa Val His Leu Gln  Gln His Met Arg Arg  His His Ser 
    1310                 1315                 1320             


Gly Xaa  Asp Ala Leu Tyr Phe  Xaa Gly Leu Glu Gly  Ala Phe Gly 
    1325                 1330                 1335             


Xaa Val  Asn Pro Lys Tyr His  Pro Ser Arg Asn Asn  Xaa Ile Ala 
    1340                 1345                 1350             


Asn Phe  Xaa Phe Ser Ala Trp  Val Met Pro Asn Ala  Asn Xaa Asn 
    1355                 1360                 1365             


Gly Phe  Ile Ile Ala Lys Asp  Asp Gly Asn Gly Ser  Ile Tyr Tyr 
    1370                 1375                 1380             


Gly Val  Lys Ile Gln Xaa Asn  Glu Ser His Val Xaa  Leu Ser Leu 
    1385                 1390                 1395             


His Tyr  Lys Xaa Leu Gly Ser  Asn Ala Xaa Tyr Ile  Ala Lys Xaa 
    1400                 1405                 1410             


Xaa Val  Met Lys Tyr Leu Glu  Glu Ser Val Trp Leu  His Leu Leu 
    1415                 1420                 1425             


Ile Ile  Leu Glu Asp Gly Ile  Ile Glu Phe Tyr Leu  Asp Gly Asn 
    1430                 1435                 1440             


Ala Met  Pro Arg Gly Ile Lys  Ser Leu Lys Gly Glu  Ala Ile Xaa 
    1445                 1450                 1455             


Asp Gly  Pro Gly Ile Leu Arg  Ile Gly Ala Gly Ile  Asn Gly Asn 
    1460                 1465                 1470             


Asp Arg  Phe Xaa Gly Leu Met  Gln Asp Val Arg Ser  Tyr Glu Arg 
    1475                 1480                 1485             


Lys Leu  Xaa Leu Glu Glu Ile  Tyr Glu Leu His Ala  Met Pro Ala 
    1490                 1495                 1500             


Lys Ser  Asp Leu His Pro Ile  Ser Gly Tyr Leu Glu  Phe Arg Gln 
    1505                 1510                 1515             


Gly Glu  Xaa Asn Lys Ser Phe  Ile Ile Ser Ala Arg  Asp Asp Asn 
    1520                 1525                 1530             


Asp Glu  Glu Gly Glu Glu Leu  Phe Ile Leu Lys Leu  Val Ser Val 
    1535                 1540                 1545             


Tyr Gly  Gly Ala Arg Ile Ser  Glu Glu Asn Xaa Xaa  Ala Arg Leu 
    1550                 1555                 1560             


Xaa Ile  Gln Lys Ser Asp Asn  Ala Asn Gly Leu Phe  Gly Phe Xaa 
    1565                 1570                 1575             


Gly Ala  Cys Ile Pro Glu Ile  Ala Glu Glu Gly Ser  Xaa Ile Ser 
    1580                 1585                 1590             


Cys Val  Val Glu Arg Xaa Arg  Gly Ala Leu Asp Tyr  Val His Val 
    1595                 1600                 1605             


Phe Tyr  Xaa Ile Ser Gln Ile  Glu Xaa Asp Gly Ile  Asn Tyr Leu 
    1610                 1615                 1620             


Val Asp  Asp Phe Ala Asn Ala  Ser Gly Xaa Ile Xaa  Phe Leu Pro 
    1625                 1630                 1635             


Trp Gln  Arg Ser Glu Val Leu  Asn Ile Tyr Val Leu  Asp Asp Asp 
    1640                 1645                 1650             


Ile Pro  Glu Leu Asn Glu Tyr  Phe Arg Val Xaa Leu  Val Ser Ala 
    1655                 1660                 1665             


Ile Pro  Gly Asp Gly Lys Leu  Gly Ser Xaa Pro Xaa  Ser Gly Ala 
    1670                 1675                 1680             


Ser Ile  Asp Pro Glu Lys Glu  Xaa Xaa Asp Ile Xaa  Ile Lys Ala 
    1685                 1690                 1695             


Ser Asp  His Pro Tyr Gly Leu  Leu Gln Phe Ser Xaa  Gly Leu Pro 
    1700                 1705                 1710             


Pro Gln  Pro Lys Asp Ala Met  Xaa Leu Pro Ala Ser  Ser Val Pro 
    1715                 1720                 1725             


His Ile  Xaa Val Glu Glu Glu  Asp Gly Glu Ile Arg  Leu Leu Val 
    1730                 1735                 1740             


Ile Arg  Ala Gln Gly Leu Leu  Gly Arg Val Xaa Ala  Glu Phe Arg 
    1745                 1750                 1755             


Xaa Val  Ser Leu Xaa Ala Phe  Ser Pro Glu Asp Tyr  Gln Asn Val 
    1760                 1765                 1770             


Ala Gly  Xaa Leu Glu Phe Gln  Pro Gly Glu Arg Tyr  Lys Tyr Ile 
    1775                 1780                 1785             


Phe Ile  Asn Ile Xaa Asp Asn  Ser Ile Pro Glu Leu  Glu Lys Ser 
    1790                 1795                 1800             


Phe Lys  Val Glu Leu Leu Asn  Leu Glu Gly Gly Val  Ala Glu Leu 
    1805                 1810                 1815             


Phe Arg  Val Asp Gly Ser Gly  Ser Gly Asp Gly Asp  Met Glu Phe 
    1820                 1825                 1830             


Phe Leu  Pro Xaa Ile His Lys  Arg Ala Ser Leu Gly  Val Ala Ser 
    1835                 1840                 1845             


Gln Ile  Leu Val Xaa Ile Ala  Ala Ser Asp His Ala  His Gly Val 
    1850                 1855                 1860             


Phe Glu  Phe Ser Pro Glu Ser  Leu Phe Val Ser Gly  Xaa Glu Pro 
    1865                 1870                 1875             


Glu Asp  Gly Tyr Ser Xaa Val  Xaa Leu Asn Val Ile  Arg His His 
    1880                 1885                 1890             


Gly Xaa  Leu Ser Pro Val Xaa  Leu His Trp Asn Ile  Asp Ser Asp 
    1895                 1900                 1905             


Pro Asp  Gly Asp Leu Ala Phe  Xaa Ser Gly Asn Ile  Xaa Phe Glu 
    1910                 1915                 1920             


Ile Gly  Gln Xaa Ser Ala Asn  Ile Xaa Val Glu Ile  Leu Pro Asp 
    1925                 1930                 1935             


Glu Asp  Pro Glu Leu Asp Lys  Ala Phe Ser Val Ser  Val Leu Ser 
    1940                 1945                 1950             


Val Ser  Ser Gly Ser Leu Gly  Ala His Ile Asn Ala  Xaa Leu Xaa 
    1955                 1960                 1965             


Val Leu  Ala Ser Asp Asp Pro  Tyr Gly Ile Phe Ile  Phe Ser Glu 
    1970                 1975                 1980             


Lys Asn  Arg Pro Val Lys Val  Glu Glu Ala Xaa Gln  Asn Ile Xaa 
    1985                 1990                 1995             


Leu Ser  Ile Ile Arg Leu Lys  Gly Leu Met Gly Lys  Val Leu Val 
    2000                 2005                 2010             


Ser Tyr  Ala Xaa Leu Asp Asp  Met Glu Lys Pro Pro  Tyr Phe Pro 
    2015                 2020                 2025             


Pro Asn  Leu Ala Arg Ala Xaa  Gln Gly Arg Asp Tyr  Ile Pro Ala 
    2030                 2035                 2040             


Ser Gly  Phe Ala Leu Phe Gly  Ala Asn Gln Ser Glu  Ala Xaa Ile 
    2045                 2050                 2055             


Ala Ile  Ser Ile Leu Asp Asp  Asp Glu Pro Glu Arg  Ser Glu Ser 
    2060                 2065                 2070             


Val Phe  Ile Glu Leu Leu Asn  Ser Xaa Leu Val Ala  Lys Val Gln 
    2075                 2080                 2085             


Ser Arg  Ser Ile Pro Asn Ser  Pro Arg Leu Gly Pro  Lys Val Glu 
    2090                 2095                 2100             


Xaa Ile  Ala Gln Leu Ile Ile  Ile Ala Asn Asp Asp  Ala Phe Gly 
    2105                 2110                 2115             


Xaa Leu  Gln Leu Ser Ala Pro  Ile Val Arg Val Ala  Glu Asn His 
    2120                 2125                 2130             


Val Gly  Pro Ile Ile Asn Val  Xaa Arg Xaa Gly Gly  Ala Phe Ala 
    2135                 2140                 2145             


Asp Val  Ser Val Lys Phe Lys  Ala Val Pro Ile Xaa  Ala Ile Ala 
    2150                 2155                 2160             


Gly Glu  Asp Tyr Ser Ile Ala  Ser Ser Asp Val Val  Leu Leu Glu 
    2165                 2170                 2175             


Gly Glu  Xaa Ser Lys Ala Val  Pro Ile Tyr Val Ile  Asn Asp Ile 
    2180                 2185                 2190             


Tyr Pro  Glu Leu Glu Glu Ser  Phe Leu Val Gln Leu  Met Asn Glu 
    2195                 2200                 2205             


Xaa Xaa  Gly Gly Ala Arg Leu  Gly Ala Leu Xaa Glu  Ala Val Ile 
    2210                 2215                 2220             


Ile Ile  Glu Ala Ser Asp Asp  Pro Tyr Gly Leu Phe  Gly Phe Gln 
    2225                 2230                 2235             


Ile Xaa  Lys Leu Ile Val Glu  Glu Pro Glu Phe Asn  Ser Val Lys 
    2240                 2245                 2250             


Val Asn  Leu Pro Ile Ile Arg  Asn Ser Gly Xaa Leu  Gly Asn Val 
    2255                 2260                 2265             


Xaa Val  Gln Trp Val Ala Xaa  Ile Asn Gly Gln Leu  Ala Xaa Gly 
    2270                 2275                 2280             


Asp Leu  Arg Val Val Ser Gly  Asn Val Xaa Phe Ala  Pro Gly Glu 
    2285                 2290                 2295             


Xaa Ile  Gln Xaa Leu Leu Leu  Glu Val Leu Ala Asp  Asp Val Pro 
    2300                 2305                 2310             


Glu Ile  Glu Glu Val Ile Gln  Val Gln Leu Xaa Asp  Ala Ser Gly 
    2315                 2320                 2325             


Gly Gly  Xaa Ile Gly Leu Asp  Arg Ile Ala Asn Ile  Ile Ile Pro 
    2330                 2335                 2340             


Ala Asn  Asp Asp Pro Tyr Gly  Xaa Val Ala Phe Ala  Gln Met Val 
    2345                 2350                 2355             


Tyr Arg  Val Gln Glu Pro Leu  Glu Arg Ser Ser Cys  Ala Asn Ile 
    2360                 2365                 2370             


Xaa Val  Arg Arg Ser Gly Gly  His Phe Gly Arg Leu  Leu Leu Phe 
    2375                 2380                 2385             


Tyr Ser  Xaa Ser Asp Ile Asp  Val Val Ala Leu Ala  Met Glu Glu 
    2390                 2395                 2400             


Gly Gln  Asp Leu Leu Ser Tyr  Tyr Glu Ser Pro Ile  Gln Gly Val 
    2405                 2410                 2415             


Pro Asp  Pro Leu Trp Arg Xaa  Trp Met Asn Val Ser  Ala Val Gly 
    2420                 2425                 2430             


Glu Pro  Leu Tyr Xaa Cys Ala  Xaa Leu Cys Leu Lys  Glu Gln Ala 
    2435                 2440                 2445             


Cys Ser  Ala Phe Ser Phe Phe  Ser Ala Ser Glu Gly  Pro Gln Cys 
    2450                 2455                 2460             


Phe Trp  Met Xaa Ser Trp Ile  Ser Pro Ala Val Asn  Asn Ser Asp 
    2465                 2470                 2475             


Phe Trp  Xaa Tyr Arg Lys Asn  Met Xaa Arg Val Ala  Ser Leu Phe 
    2480                 2485                 2490             


Ser Gly  Gln Ala Val Ala Gly  Ser Asp Tyr Glu Pro  Val Xaa Arg 
    2495                 2500                 2505             


Gln Trp  Ala Ile Met Gln Glu  Gly Asp Glu Phe Ala  Asn Leu Xaa 
    2510                 2515                 2520             


Val Ser  Ile Leu Pro Asp Asp  Phe Pro Glu Met Asp  Glu Ser Phe 
    2525                 2530                 2535             


Leu Ile  Ser Leu Leu Glu Val  His Leu Met Asn Ile  Ser Ala Ser 
    2540                 2545                 2550             


Leu Lys  Asn Gln Pro Xaa Ile  Gly Gln Pro Asn Ile  Ser Xaa Val 
    2555                 2560                 2565             


Val Ile  Ala Leu Asn Gly Asp  Ala Phe Gly Val Phe  Val Ile Tyr 
    2570                 2575                 2580             


Asn Ile  Ser Pro Asn Xaa Ser  Glu Asp Gly Leu Phe  Val Glu Val 
    2585                 2590                 2595             


Gln Glu  Gln Pro Gln Xaa Leu  Val Glu Leu Met Ile  His Arg Xaa 
    2600                 2605                 2610             


Gly Gly  Ser Leu Gly Gln Val  Ala Val Glu Trp Arg  Val Val Gly 
    2615                 2620                 2625             


Gly Xaa  Ala Xaa Glu Gly Leu  Asp Phe Ile Gly Ala  Gly Glu Ile 
    2630                 2635                 2640             


Leu Xaa  Phe Ala Glu Gly Glu  Xaa Lys Lys Xaa Val  Ile Leu Xaa 
    2645                 2650                 2655             


Ile Leu  Asp Asp Ser Glu Pro  Glu Asp Asp Glu Ser  Ile Ile Val 
    2660                 2665                 2670             


Ser Leu  Val Tyr Xaa Glu Gly  Gly Ser Arg Ile Leu  Pro Ser Ser 
    2675                 2680                 2685             


Asp Xaa  Val Arg Val Asn Ile  Leu Ala Asn Asp Asn  Val Ala Gly 
    2690                 2695                 2700             


Ile Val  Ser Phe Gln Xaa Ala  Ser Arg Ser Val Ile  Gly His Glu 
    2705                 2710                 2715             


Gly Glu  Ile Leu Gln Phe His  Val Ile Arg Xaa Phe  Pro Gly Arg 
    2720                 2725                 2730             


Gly Asn  Val Xaa Val Asn Trp  Lys Ile Ile Gly Gln  Asn Leu Glu 
    2735                 2740                 2745             


Leu Asn  Phe Ala Asn Phe Ser  Gly Gln Leu Phe Phe  Pro Glu Gly 
    2750                 2755                 2760             


Ser Leu  Asn Xaa Xaa Leu Phe  Val His Leu Leu Asp  Asp Asn Ile 
    2765                 2770                 2775             


Pro Glu  Glu Lys Glu Val Tyr  Gln Val Ile Leu Tyr  Asp Val Arg 
    2780                 2785                 2790             


Xaa Gln  Gly Val Pro Pro Ala  Gly Ile Ala Leu Leu  Asp Ala Gln 
    2795                 2800                 2805             


Gly Tyr  Ala Ala Val Leu Xaa  Val Glu Ala Ser Asp  Glu Pro His 
    2810                 2815                 2820             


Gly Val  Leu Asn Phe Ala Leu  Ser Ser Arg Phe Val  Leu Leu Gln 
    2825                 2830                 2835             


Glu Ala  Asn Ile Xaa Ile Gln  Leu Phe Ile Asn Arg  Glu Phe Gly 
    2840                 2845                 2850             


Ser Leu  Gly Ala Ile Asn Val  Xaa Tyr Xaa Xaa Val  Pro Gly Met 
    2855                 2860                 2865             


Leu Ser  Leu Lys Asn Gln Xaa  Val Gly Asn Leu Ala  Glu Pro Glu 
    2870                 2875                 2880             


Val Asp  Phe Val Pro Ile Ile  Gly Phe Leu Ile Leu  Glu Glu Gly 
    2885                 2890                 2895             


Glu Xaa  Ala Ala Ala Ile Asn  Ile Xaa Ile Leu Glu  Asp Asp Val 
    2900                 2905                 2910             


Pro Glu  Leu Glu Glu Tyr Phe  Leu Val Asn Leu Xaa  Tyr Val Gly 
    2915                 2920                 2925             


Leu Xaa  Met Ala Ala Ser Xaa  Ser Phe Pro Pro Arg  Leu Asp Ser 
    2930                 2935                 2940             


Glu Gly  Leu Xaa Ala Gln Val  Ile Ile Asp Ala Asn  Asp Gly Ala 
    2945                 2950                 2955             


Arg Gly  Val Ile Glu Trp Gln  Gln Ser Arg Phe Glu  Val Asn Glu 
    2960                 2965                 2970             


Xaa His  Gly Ser Leu Xaa Leu  Val Ala Gln Arg Ser  Arg Glu Pro 
    2975                 2980                 2985             


Leu Gly  His Val Ser Leu Phe  Val Tyr Ala Gln Asn  Leu Glu Ala 
    2990                 2995                 3000             


Gln Val  Gly Leu Asp Tyr Ile  Phe Xaa Pro Met Ile  Leu His Phe 
    3005                 3010                 3015             


Ala Asp  Gly Glu Arg Tyr Lys  Asn Val Asn Ile Met  Ile Leu Asp 
    3020                 3025                 3030             


Asp Asp  Ile Pro Glu Gly Asp  Glu Lys Phe Gln Leu  Ile Leu Xaa 
    3035                 3040                 3045             


Asn Pro  Ser Pro Gly Leu Glu  Leu Gly Lys Asn Xaa  Ile Ala Leu 
    3050                 3055                 3060             


Ile Ile  Val Leu Ala Asn Asp  Asp Gly Pro Gly Val  Leu Ser Phe 
    3065                 3070                 3075             


Asn Asn  Ser Glu His Phe Phe  Leu Arg Glu Pro Xaa  Ala Leu Tyr 
    3080                 3085                 3090             


Val Gln  Glu Ser Val Ala Val  Leu Tyr Ile Val Arg  Glu Pro Ala 
    3095                 3100                 3105             


Gln Gly  Leu Phe Gly Xaa Val  Xaa Val Gln Phe Ile  Val Xaa Glu 
    3110                 3115                 3120             


Val Asn  Ser Ser Asn Glu Ser  Lys Asp Leu Xaa Pro  Ser Lys Gly 
    3125                 3130                 3135             


Tyr Ile  Val Leu Glu Glu Gly  Val Arg Phe Lys Ala  Leu Gln Ile 
    3140                 3145                 3150             


Ser Ala  Ile Leu Asp Xaa Glu  Pro Glu Met Asp Glu  Tyr Phe Val 
    3155                 3160                 3165             


Cys Xaa  Leu Phe Asn Pro Xaa  Gly Gly Ala Arg Leu  Gly Val His 
    3170                 3175                 3180             


Val Gln  Xaa Leu Ile Xaa Val  Leu Gln Asn Gln Ala  Pro Leu Gly 
    3185                 3190                 3195             


Leu Phe  Ser Ile Ser Ala Val  Glu Asn Arg Ala Xaa  Ser Ile Asp 
    3200                 3205                 3210             


Ile Glu  Glu Ala Asn Arg Xaa  Val Tyr Leu Asn Val  Ser Arg Xaa 
    3215                 3220                 3225             


Asn Gly  Ile Asp Leu Ala Val  Ser Val Gln Trp Glu  Xaa Val Ser 
    3230                 3235                 3240             


Glu Xaa  Ala Phe Gly Met Arg  Gly Met Asp Val Val  Phe Ser Val 
    3245                 3250                 3255             


Phe Gln  Ser Phe Leu Asp Glu  Ser Ala Ser Gly Trp  Cys Phe Phe 
    3260                 3265                 3270             


Xaa Leu  Glu Asn Leu Ile Tyr  Gly Ile Met Leu Arg  Lys Ser Ser 
    3275                 3280                 3285             


Val Xaa  Val Tyr Arg Trp Gln  Gly Ile Phe Ile Pro  Val Glu Asp 
    3290                 3295                 3300             


Leu Asn  Ile Glu Asn Pro Lys  Xaa Cys Glu Ala Phe  Asn Ile Gly 
    3305                 3310                 3315             


Phe Ser  Pro Tyr Phe Val Ile  Xaa His Glu Glu Arg  Asn Glu Glu 
    3320                 3325                 3330             


Lys Pro  Ser Leu Asn Ser Val  Phe Xaa Phe Xaa Ser  Gly Phe Lys 
    3335                 3340                 3345             


Leu Phe  Leu Val Gln Xaa Ile  Ile Ile Leu Glu Ser  Ser Gln Val 
    3350                 3355                 3360             


Arg Tyr  Phe Xaa Ser Asp Ser  Gln Asp Tyr Leu Ile  Ile Ala Ser 
    3365                 3370                 3375             


Gln Arg  Asp Asp Ser Glu Leu  Xaa Gln Val Phe Arg  Trp Asn Gly 
    3380                 3385                 3390             


Gly Ser  Phe Val Leu His Gln  Lys Leu Pro Val Arg  Gly Val Leu 
    3395                 3400                 3405             


Xaa Val  Ala Leu Phe Asn Lys  Gly Gly Ser Val Phe  Leu Ala Ile 
    3410                 3415                 3420             


Ser Gln  Ala Asn Ala Arg Leu  Asn Ser Leu Leu Phe  Arg Trp Ser 
    3425                 3430                 3435             


Gly Ser  Gly Phe Ile Asn Phe  Gln Glu Val Pro Val  Ser Gly Xaa 
    3440                 3445                 3450             


Xaa Glu  Val Glu Ala Leu Ser  Ser Ala Asn Asp Ile  Tyr Leu Ile 
    3455                 3460                 3465             


Phe Ala  Glu Asn Val Phe Leu  Gly Asp Gln Asn Ser  Ile Asp Ile 
    3470                 3475                 3480             


Phe Ile  Trp Glu Met Gly Gln  Ser Ser Phe Arg Tyr  Phe Gln Ser 
    3485                 3490                 3495             


Val Asp  Phe Ala Ala Val Asn  Arg Ile His Ser Phe  Xaa Pro Ala 
    3500                 3505                 3510             


Ser Gly  Ile Ala His Ile Leu  Leu Ile Gly Gln Asp  Met Ser Ala 
    3515                 3520                 3525             


Leu Tyr  Cys Trp Asn Ser Glu  Arg Asn Gln Phe Ser  Phe Val Leu 
    3530                 3535                 3540             


Glu Val  Pro Ser Ala Tyr Asp  Val Ala Ser Val Xaa  Val Lys Ser 
    3545                 3550                 3555             


Leu Asn  Ser Ser Lys Asn Leu  Ile Ala Leu Val Gly  Ala His Ser 
    3560                 3565                 3570             


His Ile  Tyr Glu Leu Ala Tyr  Ile Ser Ser His Ser  Asp Phe Ile 
    3575                 3580                 3585             


Pro Ser  Ser Gly Glu Leu Ile  Phe Glu Pro Gly Glu  Arg Glu Ala 
    3590                 3595                 3600             


Xaa Ile  Ala Val Asn Ile Leu  Asp Asp Xaa Val Pro  Glu Lys Glu 
    3605                 3610                 3615             


Glu Ser  Phe Lys Val Gln Leu  Lys Asn Pro Lys Gly  Gly Ala Glu 
    3620                 3625                 3630             


Ile Gly  Ile Asn Asp Ser Val  Xaa Ile Xaa Ile Leu  Ser Asn Asp 
    3635                 3640                 3645             


Asp Ala  Tyr Gly Ile Val Ala  Phe Ala Gln Asn Ser  Leu Tyr Lys 
    3650                 3655                 3660             


Gln Val  Glu Glu Met Glu Gln  Asp Ser Leu Val Xaa  Leu Asn Val 
    3665                 3670                 3675             


Glu Arg  Leu Lys Gly Xaa Tyr  Gly Arg Ile Xaa Ile  Ala Trp Glu 
    3680                 3685                 3690             


Ala Asp  Gly Ser Ile Ser Asp  Ile Phe Pro Xaa Ser  Gly Val Ile 
    3695                 3700                 3705             


Leu Phe  Xaa Glu Gly Gln Val  Leu Ser Xaa Ile Xaa  Leu Xaa Ile 
    3710                 3715                 3720             


Leu Ala  Asp Asn Ile Pro Glu  Leu Ser Glu Val Val  Ile Val Xaa 
    3725                 3730                 3735             


Leu Xaa  Arg Ile Xaa Xaa Glu  Gly Val Glu Asp Ser  Tyr Lys Gly 
    3740                 3745                 3750             


Ala Xaa  Ile Asp Gln Asp Arg  Ser Lys Ser Val Ile  Xaa Xaa Leu 
    3755                 3760                 3765             


Pro Asn  Asp Ser Pro Phe Gly  Leu Val Gly Trp Arg  Ala Ala Ser 
    3770                 3775                 3780             


Val Phe  Ile Arg Val Ala Glu  Pro Lys Glu Asn Xaa  Xaa Xaa Leu 
    3785                 3790                 3795             


Gln Leu  Gln Ile Ala Arg Asp  Lys Gly Leu Leu Gly  Asp Ile Ala 
    3800                 3805                 3810             


Ile His  Leu Arg Ala Gln Pro  Asn Phe Leu Leu His  Val Asp Asn 
    3815                 3820                 3825             


Gln Ala  Xaa Glu Asn Glu Asp  Tyr Val Leu Gln Glu  Xaa Ile Ile 
    3830                 3835                 3840             


Ile Met  Lys Glu Asn Ile Lys  Glu Ala His Ala Glu  Val Ser Ile 
    3845                 3850                 3855             


Leu Pro  Asp Asp Leu Pro Glu  Leu Glu Glu Gly Phe  Ile Val Xaa 
    3860                 3865                 3870             


Ile Xaa  Glu Val Asn Leu Val  Asn Ser Asp Phe Ser  Xaa Gly Gln 
    3875                 3880                 3885             


Pro Ser  Val Arg Arg Pro Gly  Met Glu Ile Ala Glu  Ile Met Ile 
    3890                 3895                 3900             


Glu Glu  Asn Asp Asp Pro Arg  Gly Ile Phe Met Phe  His Val Xaa 
    3905                 3910                 3915             


Arg Gly  Ala Gly Glu Val Ile  Xaa Ala Tyr Glu Val  Pro Pro Pro 
    3920                 3925                 3930             


Leu Asn  Val Leu Gln Val Pro  Val Val Arg Leu Ala  Gly Ser Phe 
    3935                 3940                 3945             


Gly Ala  Val Asn Val Tyr Trp  Lys Ala Ser Pro Asp  Ser Ala Gly 
    3950                 3955                 3960             


Leu Glu  Asp Phe Lys Pro Ser  His Gly Ile Leu Glu  Phe Ala Asp 
    3965                 3970                 3975             


Lys Gln  Val Xaa Ala Met Ile  Glu Ile Xaa Ile Ile  Asp Asp Ala 
    3980                 3985                 3990             


Glu Phe  Glu Leu Xaa Glu Xaa  Phe Asn Ile Ser Leu  Ile Ser Val 
    3995                 4000                 4005             


Ala Gly  Gly Gly Arg Leu Gly  Asp Asp Val Val Val  Xaa Val Val 
    4010                 4015                 4020             


Ile Pro  Gln Asn Asp Ser Pro  Phe Gly Val Phe Gly  Phe Glu Glu 
    4025                 4030                 4035             


Lys Xaa  Val Met Ile Asp Glu  Ser Leu Ser Ser Asp  Asp Pro Asp 
    4040                 4045                 4050             


Ser Tyr  Val Xaa Leu Xaa Val  Val Arg Ser Pro Gly  Gly Lys Gly 
    4055                 4060                 4065             


Xaa Val  Arg Leu Glu Trp Xaa  Ile Asp Glu Lys Ala  Lys His Asn 
    4070                 4075                 4080             


Leu Ser  Pro Leu Asn Gly Xaa  Leu His Phe Asp Glu  Xaa Glu Ser 
    4085                 4090                 4095             


Gln Lys  Xaa Ile Val Leu His  Xaa Leu Gln Asp Xaa  Val Leu Glu 
    4100                 4105                 4110             


Glu Asp  Arg Arg Phe Xaa Ile  Gln Leu Ile Ser Ile  Asp Glu Val 
    4115                 4120                 4125             


Glu Ile  Ser Pro Val Lys Gly  Ser Ala Ser Ile Ile  Ile Arg Gly 
    4130                 4135                 4140             


Asp Lys  Arg Ala Ser Gly Glu  Val Gly Ile Ala Pro  Ser Ser Arg 
    4145                 4150                 4155             


His Ile  Leu Ile Gly Glu Pro  Ser Ala Lys Tyr Asn  Gly Xaa Ala 
    4160                 4165                 4170             


Ile Ile  Ser Leu Val Arg Gly  Pro Gly Ile Leu Gly  Glu Val Xaa 
    4175                 4180                 4185             


Val Phe  Trp Arg Ile Phe Pro  Pro Ser Val Gly Glu  Phe Ala Glu 
    4190                 4195                 4200             


Xaa Ser  Gly Lys Leu Xaa Met  Arg Asp Glu Gln Ser  Ala Val Ile 
    4205                 4210                 4215             


Val Val  Ile Gln Ala Leu Asn  Asp Asp Ile Pro Glu  Glu Lys Ser 
    4220                 4225                 4230             


Phe Tyr  Glu Phe Gln Leu Xaa  Ala Val Ser Glu Gly  Gly Val Leu 
    4235                 4240                 4245             


Ser Glu  Ser Ser Ser Xaa Ala  Asn Ile Xaa Val Val  Ala Ser Asp 
    4250                 4255                 4260             


Ser Pro  Tyr Gly Arg Phe Ala  Phe Ser His Glu Gln  Leu Arg Val 
    4265                 4270                 4275             


Ser Glu  Ala Gln Arg Val Asn  Ile Xaa Ile Ile Arg  Ser Ser Gly 
    4280                 4285                 4290             


Asp Phe  Gly His Val Arg Leu  Trp Tyr Lys Xaa Met  Ser Gly Xaa 
    4295                 4300                 4305             


Ala Glu  Ala Gly Leu Asp Phe  Val Pro Ala Ala Gly  Glu Leu Leu 
    4310                 4315                 4320             


Phe Glu  Ala Gly Glu Met Arg  Lys Ser Leu His Val  Glu Ile Leu 
    4325                 4330                 4335             


Asp Asp  Asp Tyr Pro Glu Gly  Pro Glu Glu Phe Ser  Leu Xaa Ile 
    4340                 4345                 4350             


Xaa Lys  Val Glu Leu Gln Gly  Arg Gly Tyr Asp Phe  Xaa Ile Gln 
    4355                 4360                 4365             


Glu Asn  Gly Leu Gln Ile Asp  Gln Pro Pro Glu Ile  Gly Asn Ile 
    4370                 4375                 4380             


Ser Ile  Val Arg Ile Ile Ile  Met Lys Asn Asp Asn  Ala Glu Gly 
    4385                 4390                 4395             


Ile Ile  Glu Phe Asp Pro Lys  Tyr Xaa Ala Phe Glu  Val Glu Glu 
    4400                 4405                 4410             


Asp Val  Gly Leu Ile Met Ile  Pro Val Val Arg Leu  His Gly Xaa 
    4415                 4420                 4425             


Tyr Gly  Tyr Val Xaa Ala Asp  Phe Ile Ser Gln Ser  Ser Ser Ala 
    4430                 4435                 4440             


Ser Pro  Gly Gly Val Asp Tyr  Ile Leu His Gly Ser  Xaa Val Xaa 
    4445                 4450                 4455             


Phe Gln  His Gly Gln Asn Leu  Ser Phe Ile Asn Ile  Ser Ile Ile 
    4460                 4465                 4470             


Asp Asp  Asn Glu Ser Glu Phe  Glu Glu Pro Ile Glu  Ile Leu Leu 
    4475                 4480                 4485             


Xaa Gly  Ala Xaa Gly Gly Ala  Val Leu Gly Arg His  Leu Val Ser 
    4490                 4495                 4500             


Arg Ile  Ile Ile Ala Lys Ser  Asp Ser Pro Phe Gly  Val Ile Arg 
    4505                 4510                 4515             


Phe Leu  Asn Gln Ser Lys Ile  Ser Ile Ala Asn Pro  Asn Ser Xaa 
    4520                 4525                 4530             


Met Ile  Leu Ser Leu Val Leu  Glu Arg Xaa Gly Gly  Leu Leu Gly 
    4535                 4540                 4545             


Glu Ile  Gln Val Asn Trp Glu  Xaa Val Gly Pro Asn  Ser Gln Glu 
    4550                 4555                 4560             


Ala Leu  Leu Pro Gln Asn Arg  Asp Ile Ala Asp Pro  Val Ser Gly 
    4565                 4570                 4575             


Leu Phe  Tyr Phe Gly Glu Gly  Glu Gly Gly Val Arg  Xaa Ile Ile 
    4580                 4585                 4590             


Leu Xaa  Ile Tyr Pro His Glu  Glu Ile Glu Val Glu  Glu Xaa Phe 
    4595                 4600                 4605             


Ile Ile  Lys Leu His Leu Val  Lys Gly Glu Ala Lys  Leu Asp Ser 
    4610                 4615                 4620             


Arg Ala  Lys Asp Val Xaa Leu  Xaa Ile Gln Glu Phe  Gly Asp Pro 
    4625                 4630                 4635             


Asn Gly  Val Val Gln Phe Ala  Pro Glu Xaa Leu Ser  Lys Lys Xaa 
    4640                 4645                 4650             


Tyr Ser  Glu Pro Leu Ala Leu  Glu Gly Pro Leu Leu  Ile Xaa Phe 
    4655                 4660                 4665             


Phe Val  Arg Arg Val Lys Gly  Xaa Phe Gly Glu Ile  Met Val Tyr 
    4670                 4675                 4680             


Trp Glu  Leu Ser Ser Glu Phe  Asp Ile Xaa Glu Asp  Phe Leu Ser 
    4685                 4690                 4695             


Xaa Ser  Gly Phe Phe Xaa Ile  Ala Asp Gly Glu Ser  Glu Ala Ser 
    4700                 4705                 4710             


Phe Asp  Val His Leu Leu Pro  Asp Glu Val Pro Glu  Ile Glu Glu 
    4715                 4720                 4725             


Asp Tyr  Val Ile Gln Leu Val  Ser Val Glu Gly Gly  Ala Glu Leu 
    4730                 4735                 4740             


Asp Leu  Glu Lys Ser Ile Xaa  Trp Phe Ser Val Tyr  Ala Asn Asp 
    4745                 4750                 4755             


Asp Pro  His Gly Val Phe Ala  Leu Tyr Ser Asp Arg  Gln Ser Ile 
    4760                 4765                 4770             


Leu Ile  Gly Gln Asn Leu Ile  Arg Ser Ile Gln Ile  Asn Ile Xaa 
    4775                 4780                 4785             


Arg Leu  Ala Gly Xaa Phe Gly  Asp Val Ala Val Gly  Leu Arg Ile 
    4790                 4795                 4800             


Ser Ser  Asp His Lys Glu Gln  Pro Ile Val Xaa Glu  Asn Ala Glu 
    4805                 4810                 4815             


Arg Gln  Leu Val Val Lys Asp  Gly Ala Xaa Tyr Lys  Val Asp Val 
    4820                 4825                 4830             


Val Pro  Ile Lys Asn Gln Val  Phe Leu Ser Leu Gly  Ser Asn Phe 
    4835                 4840                 4845             


Xaa Leu  Gln Leu Val Xaa Val  Met Leu Val Gly Gly  Arg Phe Tyr 
    4850                 4855                 4860             


Gly Met  Pro Xaa Ile Leu Gln  Glu Ala Lys Ser Ala  Val Leu Pro 
    4865                 4870                 4875             


Val Ser  Glu Lys Ala Ala Asn  Ser Gln Val Gly Phe  Glu Ser Xaa 
    4880                 4885                 4890             


Ala Phe  Gln Leu Met Asn Ile  Xaa Ala Gly Xaa Ser  His Val Met 
    4895                 4900                 4905             


Ile Ser  Arg Arg Gly Xaa Tyr  Gly Ala Leu Ser Val  Ala Trp Xaa 
    4910                 4915                 4920             


Xaa Gly  Tyr Ala Pro Gly Leu  Glu Ile Pro Glu Phe  Ile Val Val 
    4925                 4930                 4935             


Gly Asn  Met Xaa Pro Xaa Leu  Gly Ser Leu Ser Phe  Ser His Gly 
    4940                 4945                 4950             


Glu Gln  Arg Lys Gly Val Phe  Leu Trp Xaa Phe Pro  Ser Pro Gly 
    4955                 4960                 4965             


Trp Pro  Glu Ala Phe Val Leu  His Leu Ser Gly Val  Gln Ser Ser 
    4970                 4975                 4980             


Ala Pro  Gly Gly Ala Gln Leu  Arg Ser Gly Phe Ile  Val Ala Glu 
    4985                 4990                 4995             


Ile Glu  Pro Met Gly Val Phe  Gln Phe Ser Xaa Ser  Ser Arg Asn 
    5000                 5005                 5010             


Ile Ile  Val Ser Glu Asp Xaa  Gln Met Ile Arg Leu  His Val Gln 
    5015                 5020                 5025             


Arg Leu  Phe Gly Phe His Ser  Asp Leu Ile Lys Val  Ser Tyr Gln 
    5030                 5035                 5040             


Xaa Xaa  Ala Gly Ser Ala Lys  Pro Leu Glu Asp Phe  Glu Pro Val 
    5045                 5050                 5055             


Gln Asn  Gly Glu Leu Phe Phe  Gln Lys Phe Gln Xaa  Glu Val Asp 
    5060                 5065                 5070             


Phe Glu  Ile Xaa Ile Ile Asn  Asp Gln Leu Ser Glu  Ile Glu Glu 
    5075                 5080                 5085             


Phe Phe  Tyr Ile Asn Leu Xaa  Ser Val Glu Ile Arg  Gly Leu Gln 
    5090                 5095                 5100             


Lys Phe  Asp Val Asn Trp Ser  Pro Arg Leu Asn Leu  Asp Phe Ser 
    5105                 5110                 5115             


Val Ala  Val Ile Xaa Ile Leu  Asp Asn Asp Asp Leu  Ala Gly Met 
    5120                 5125                 5130             


Asp Ile  Ser Phe Pro Glu Xaa  Xaa Val Ala Val Ala  Val Asp Xaa 
    5135                 5140                 5145             


Xaa Leu  Ile Pro Val Glu Xaa  Glu Ser Xaa Xaa Tyr  Leu Ser Xaa 
    5150                 5155                 5160             


Ser Lys  Xaa Xaa Xaa Ile Leu  Gln Pro Xaa Asn Val  Val Ala Ile 
    5165                 5170                 5175             


Val Xaa  Glu Ala Xaa Gly Val  Ser Ala Ile Pro Glu  Lys Leu Val 
    5180                 5185                 5190             


Xaa Leu  His Gly Xaa Pro Ala  Val Ser Glu Lys Pro  Asp Val Ala 
    5195                 5200                 5205             


Xaa Val  Xaa Ala Asn Val Ser  Ile His Gly Xaa Phe  Ser Leu Gly 
    5210                 5215                 5220             


Pro Ser  Ile Val Tyr Ile Glu  Glu Glu Met Lys Asn  Gly Xaa Phe 
    5225                 5230                 5235             


Asn Xaa  Ala Glu Val Leu Ile  Arg Arg Xaa Gly Gly  Phe Xaa Gly 
    5240                 5245                 5250             


Asn Val  Ser Ile Xaa Val Lys  Xaa Phe Gly Glu Arg  Cys Ala Gln 
    5255                 5260                 5265             


Met Glu  Pro Asn Ala Leu Pro  Phe Arg Gly Ile Tyr  Gly Ile Ser 
    5270                 5275                 5280             


Asn Leu  Xaa Trp Ala Val Glu  Glu Glu Asp Phe Glu  Glu Gln Xaa 
    5285                 5290                 5295             


Leu Xaa  Leu Ile Phe Leu Asp  Gly Glu Arg Glu Arg  Lys Val Ser 
    5300                 5305                 5310             


Val Gln  Ile Leu Asp Asp Asp  Glu Pro Glu Gly Gln  Glu Phe Phe 
    5315                 5320                 5325             


Tyr Val  Phe Leu Xaa Asn Pro  Gln Gly Gly Ala Gln  Ile Val Glu 
    5330                 5335                 5340             


Glu Lys  Asp Asp Xaa Gly Phe  Ala Ala Phe Ala Met  Val Ile Ile 
    5345                 5350                 5355             


Xaa Gly  Ser Asp Leu His Asn  Gly Ile Ile Gly Phe  Ser Glu Glu 
    5360                 5365                 5370             


Ser Gln  Ser Gly Leu Glu Leu  Arg Glu Gly Ala Val  Met Arg Arg 
    5375                 5380                 5385             


Leu His  Leu Ile Val Xaa Arg  Gln Pro Asn Arg Ala  Phe Glu Asp 
    5390                 5395                 5400             


Val Lys  Val Phe Trp Arg Val  Xaa Leu Asn Lys Xaa  Val Val Val 
    5405                 5410                 5415             


Leu Gln  Lys Asp Gly Val Asn  Leu Val Glu Glu Leu  Gln Ser Val 
    5420                 5425                 5430             


Ser Gly  Xaa Xaa Xaa Cys Xaa  Met Gly Gln Xaa Lys  Cys Phe Ile 
    5435                 5440                 5445             


Ser Ile  Glu Leu Lys Pro Glu  Lys Val Pro Gln Val  Glu Val Tyr 
    5450                 5455                 5460             


Phe Phe  Val Glu Leu Tyr Glu  Ala Xaa Ala Gly Ala  Ala Ile Asn 
    5465                 5470                 5475             


Asn Ser  Ala Arg Phe Ala Gln  Ile Lys Ile Leu Glu  Ser Asp Glu 
    5480                 5485                 5490             


Ser Gln  Ser Leu Val Tyr Phe  Ser Val Gly Ser Arg  Leu Ala Val 
    5495                 5500                 5505             


Ala His  Lys Lys Ala Xaa Leu  Ile Ser Leu Gln Val  Ala Arg Asp 
    5510                 5515                 5520             


Ser Gly  Xaa Gly Leu Met Met  Ser Val Asn Phe Ser  Xaa Gln Glu 
    5525                 5530                 5535             


Leu Arg  Ser Ala Glu Xaa Ile  Gly Arg Xaa Ile Ile  Ser Pro Ala 
    5540                 5545                 5550             


Ile Ser  Gly Lys Asp Phe Val  Ile Xaa Glu Gly Xaa  Leu Val Phe 
    5555                 5560                 5565             


Glu Pro  Gly Gln Arg Ser Xaa  Val Leu Asp Val Ile  Leu Xaa Pro 
    5570                 5575                 5580             


Glu Xaa  Gly Ser Leu Asn Ser  Phe Pro Lys Arg Phe  Gln Ile Val 
    5585                 5590                 5595             


Leu Phe  Asp Pro Lys Gly Gly  Ala Arg Ile Asp Lys  Val Tyr Gly 
    5600                 5605                 5610             


Xaa Ala  Asn Ile Xaa Leu Val  Ser Asp Ala Asp Ser  Gln Ala Ile 
    5615                 5620                 5625             


Trp Gly  Leu Ala Asp Gln Leu  His Gln Pro Val Asn  Asp Asp Ile 
    5630                 5635                 5640             


Leu Asn  Arg Val Leu His Xaa  Ile Ser Met Lys Val  Ala Xaa Glu 
    5645                 5650                 5655             


Asn Xaa  Asp Glu Gln Leu Ser  Ala Met Met His Leu  Ile Glu Lys 
    5660                 5665                 5670             


Ile Xaa  Xaa Glu Gly Lys Ile  Gln Ala Phe Ser Val  Ala Ser Arg 
    5675                 5680                 5685             


Xaa Leu  Phe Tyr Glu Ile Leu  Cys Ser Leu Ile Asn  Pro Lys Arg 
    5690                 5695                 5700             


Lys Asp  Xaa Arg Gly Phe Ser  His Phe Ala Glu Val  Xaa Glu Asn 
    5705                 5710                 5715             


Phe Ala  Phe Ser Leu Leu Xaa  Asn Val Xaa Cys Gly  Ser Pro Gly 
    5720                 5725                 5730             


Glu Lys  Ser Lys Xaa Ile Leu  Asp Ser Cys Pro Tyr  Leu Ser Ile 
    5735                 5740                 5745             


Leu Ala  Leu His Trp Tyr Pro  Gln Gln Ile Asn Gly  His Lys Phe 
    5750                 5755                 5760             


Glu Gly  Lys Glu Gly Asp Tyr  Ile Arg Ile Pro Glu  Arg Leu Leu 
    5765                 5770                 5775             


Asp Val  Gln Asp Ala Glu Ile  Met Ala Gly Lys Ser  Xaa Cys Lys 
    5780                 5785                 5790             


Leu Val  Gln Phe Xaa Glu Tyr  Ser Ser Gln Gln Trp  Phe Ile Ser 
    5795                 5800                 5805             


Gly Asn  Asn Leu Pro Xaa Leu  Lys Asn Lys Val Leu  Ser Leu Ser 
    5810                 5815                 5820             


Val Lys  Gly Gln Ser Ser Gln  Leu Leu Xaa Asn Asp  Asn Glu Val 
    5825                 5830                 5835             


Leu Tyr  Arg Ile Tyr Ala Ala  Glu Pro Arg Ile Ile  Pro Gln Xaa 
    5840                 5845                 5850             


Ser Leu  Cys Leu Leu Trp Asn  Gln Ala Ala Ala Ser  Trp Leu Ser 
    5855                 5860                 5865             


Asp Ser  Gln Phe Cys Lys Val  Val Glu Glu Xaa Ala  Asp Tyr Val 
    5870                 5875                 5880             


Glu Cys  Ala Cys Ser His Met  Ser Val Tyr Ala Val  Tyr Ala Arg 
    5885                 5890                 5895             


Xaa Asp  Asn Leu Ser Ser Tyr  Asn Glu Ala Phe Phe  Xaa Ser Gly 
    5900                 5905                 5910             


Phe Ile  Cys Ile Ser Gly Leu  Cys Leu Ala Val Leu  Ser His Ile 
    5915                 5920                 5925             


Phe Cys  Ala Arg Tyr Ser Met  Phe Ala Ala Lys Leu  Leu Xaa His 
    5930                 5935                 5940             


Met Met  Ala Ala Ser Leu Gly  Xaa Gln Ile Leu Phe  Leu Ala Ser 
    5945                 5950                 5955             


Ala Tyr  Ala Ser Pro Gln Leu  Ala Glu Glu Ser Cys  Ser Ala Met 
    5960                 5965                 5970             


Ala Ala  Val Xaa His Tyr Leu  Tyr Leu Cys Gln Phe  Ser Trp Met 
    5975                 5980                 5985             


Leu Ile  Gln Ser Val Asn Phe  Trp Tyr Val Leu Val  Met Asn Asp 
    5990                 5995                 6000             


Glu His  Xaa Glu Arg Arg Tyr  Leu Leu Phe Phe Leu  Leu Ser Trp 
    6005                 6010                 6015             


Gly Leu  Pro Ala Phe Val Val  Ile Leu Leu Ile Val  Ile Leu Lys 
    6020                 6025                 6030             


Gly Ile  Tyr His Gln Ser Met  Ser Gln Ile Tyr Gly  Leu Ile His 
    6035                 6040                 6045             


Gly Asp  Leu Cys Phe Ile Pro  Asn Val Tyr Ala Ala  Leu Phe Xaa 
    6050                 6055                 6060             


Ala Ala  Leu Val Pro Leu Xaa  Cys Leu Val Val Val  Phe Val Val 
    6065                 6070                 6075             


Phe Ile  His Ala Tyr Gln Val  Lys Pro Gln Trp Lys  Ala Tyr Asp 
    6080                 6085                 6090             


Asp Val  Phe Arg Gly Arg Xaa  Asn Ala Ala Glu Ile  Pro Leu Ile 
    6095                 6100                 6105             


Leu Tyr  Leu Phe Ala Leu Ile  Ser Val Xaa Trp Leu  Trp Gly Gly 
    6110                 6115                 6120             


Leu His  Met Ala Tyr Arg His  Phe Trp Met Leu Val  Leu Phe Val 
    6125                 6130                 6135             


Ile Phe  Asn Ser Leu Gln Gly  Leu Tyr Val Phe Met  Val Tyr Phe 
    6140                 6145                 6150             


Ile Leu  His Asn Gln Met Cys  Cys Pro Met Lys Ala  Ser Tyr Xaa 
    6155                 6160                 6165             


Val Glu  Met Asn Gly His Pro  Gly Pro Ser Xaa Ala  Phe Phe Xaa 
    6170                 6175                 6180             


Pro Gly  Ser Gly Met Pro Pro  Ala Gly Gly Glu Ile  Ser Lys Ser 
    6185                 6190                 6195             


Xaa Gln  Asn Leu Ile Gly Ala  Met Glu Glu Val Pro  Pro Asp Trp 
    6200                 6205                 6210             


Glu Arg  Ala Ser Phe Gln Gln  Gly Ser Gln Ala Ser  Pro Asp Leu 
    6215                 6220                 6225             


Lys Pro  Ser Pro Gln Asn Gly  Ala Xaa Phe Pro Ser  Ser Gly Gly 
    6230                 6235                 6240             


Tyr Gly  Gln Gly Ser Leu Ile  Ala Asp Glu Glu Ser  Gln Glu Phe 
    6245                 6250                 6255             


Asp Asp  Leu Ile Phe Ala Leu  Lys Xaa Gly Ala Gly  Leu Ser Val 
    6260                 6265                 6270             


Ser Asp  Asn Glu Ser Gly Gln  Gly Ser Gln Glu Gly  Gly Xaa Leu 
    6275                 6280                 6285             


Xaa Asp  Ser Gln Ile Val Glu  Leu Arg Arg Ile Pro  Ile Ala Asp 
    6290                 6295                 6300             


Xaa His  Leu 
    6305     


<210> 1792
<211> 1608
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1179)..(1179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1255)..(1255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1270)..(1270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1277)..(1277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1304)..(1304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1306)..(1306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1321)..(1321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1361)..(1363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1397)..(1397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1439)..(1439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1452)..(1452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1484)..(1484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1492)..(1492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1548)..(1548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1554)..(1554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1564)..(1564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1566)..(1566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1587)..(1587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<400> 1792
Xaa Leu Tyr Xaa Cys Ala Xaa Leu Cys Leu Lys Glu Gln Ala Cys Ser 
1               5                   10                  15      


Ala Phe Ser Phe Phe Ser Ala Ser Glu Gly Pro Gln Cys Phe Trp Met 
            20                  25                  30          


Xaa Ser Trp Ile Ser Pro Ala Val Asn Asn Ser Asp Phe Trp Xaa Tyr 
        35                  40                  45              


Arg Lys Asn Met Xaa Arg Val Ala Ser Leu Phe Ser Gly Gln Ala Val 
    50                  55                  60                  


Ala Gly Ser Asp Tyr Glu Pro Val Xaa Arg Gln Trp Ala Ile Met Gln 
65                  70                  75                  80  


Glu Gly Asp Glu Phe Ala Asn Leu Xaa Val Ser Ile Leu Pro Asp Asp 
                85                  90                  95      


Phe Pro Glu Met Asp Glu Ser Phe Leu Ile Ser Leu Leu Glu Val His 
            100                 105                 110         


Leu Met Asn Ile Ser Ala Ser Leu Lys Asn Gln Pro Xaa Ile Gly Gln 
        115                 120                 125             


Pro Asn Ile Ser Xaa Val Val Ile Ala Leu Asn Gly Asp Ala Phe Gly 
    130                 135                 140                 


Val Phe Val Ile Tyr Asn Ile Ser Pro Asn Xaa Ser Glu Asp Gly Leu 
145                 150                 155                 160 


Phe Val Glu Val Gln Glu Gln Pro Gln Xaa Leu Val Glu Leu Met Ile 
                165                 170                 175     


His Arg Xaa Gly Gly Ser Leu Gly Gln Val Ala Val Glu Trp Arg Val 
            180                 185                 190         


Val Gly Gly Xaa Ala Xaa Glu Gly Leu Asp Phe Ile Gly Ala Gly Glu 
        195                 200                 205             


Ile Leu Xaa Phe Ala Glu Gly Glu Xaa Lys Lys Xaa Val Ile Leu Xaa 
    210                 215                 220                 


Ile Leu Asp Asp Ser Glu Pro Glu Asp Asp Glu Ser Ile Ile Val Ser 
225                 230                 235                 240 


Leu Val Tyr Xaa Glu Gly Gly Ser Arg Ile Leu Pro Ser Ser Asp Xaa 
                245                 250                 255     


Val Arg Val Asn Ile Leu Ala Asn Asp Asn Val Ala Gly Ile Val Ser 
            260                 265                 270         


Phe Gln Xaa Ala Ser Arg Ser Val Ile Gly His Glu Gly Glu Ile Leu 
        275                 280                 285             


Gln Phe His Val Ile Arg Xaa Phe Pro Gly Arg Gly Asn Val Xaa Val 
    290                 295                 300                 


Asn Trp Lys Ile Ile Gly Gln Asn Leu Glu Leu Asn Phe Ala Asn Phe 
305                 310                 315                 320 


Ser Gly Gln Leu Phe Phe Pro Glu Gly Ser Leu Asn Xaa Xaa Leu Phe 
                325                 330                 335     


Val His Leu Leu Asp Asp Asn Ile Pro Glu Glu Lys Glu Val Tyr Gln 
            340                 345                 350         


Val Ile Leu Tyr Asp Val Arg Xaa Gln Gly Val Pro Pro Ala Gly Ile 
        355                 360                 365             


Ala Leu Leu Asp Ala Gln Gly Tyr Ala Ala Val Leu Xaa Val Glu Ala 
    370                 375                 380                 


Ser Asp Glu Pro His Gly Val Leu Asn Phe Ala Leu Ser Ser Arg Phe 
385                 390                 395                 400 


Val Leu Leu Gln Glu Ala Asn Ile Xaa Ile Gln Leu Phe Ile Asn Arg 
                405                 410                 415     


Glu Phe Gly Ser Leu Gly Ala Ile Asn Val Xaa Tyr Xaa Xaa Val Pro 
            420                 425                 430         


Gly Met Leu Ser Leu Lys Asn Gln Xaa Val Gly Asn Leu Ala Glu Pro 
        435                 440                 445             


Glu Val Asp Phe Val Pro Ile Ile Gly Phe Leu Ile Leu Glu Glu Gly 
    450                 455                 460                 


Glu Xaa Ala Ala Ala Ile Asn Ile Xaa Ile Leu Glu Asp Asp Val Pro 
465                 470                 475                 480 


Glu Leu Glu Glu Tyr Phe Leu Val Asn Leu Xaa Tyr Val Gly Leu Xaa 
                485                 490                 495     


Met Ala Ala Ser Xaa Ser Phe Pro Pro Arg Leu Asp Ser Glu Gly Leu 
            500                 505                 510         


Xaa Ala Gln Val Ile Ile Asp Ala Asn Asp Gly Ala Arg Gly Val Ile 
        515                 520                 525             


Glu Trp Gln Gln Ser Arg Phe Glu Val Asn Glu Xaa His Gly Ser Leu 
    530                 535                 540                 


Xaa Leu Val Ala Gln Arg Ser Arg Glu Pro Leu Gly His Val Ser Leu 
545                 550                 555                 560 


Phe Val Tyr Ala Gln Asn Leu Glu Ala Gln Val Gly Leu Asp Tyr Ile 
                565                 570                 575     


Phe Xaa Pro Met Ile Leu His Phe Ala Asp Gly Glu Arg Tyr Lys Asn 
            580                 585                 590         


Val Asn Ile Met Ile Leu Asp Asp Asp Ile Pro Glu Gly Asp Glu Lys 
        595                 600                 605             


Phe Gln Leu Ile Leu Xaa Asn Pro Ser Pro Gly Leu Glu Leu Gly Lys 
    610                 615                 620                 


Asn Xaa Ile Ala Leu Ile Ile Val Leu Ala Asn Asp Asp Gly Pro Gly 
625                 630                 635                 640 


Val Leu Ser Phe Asn Asn Ser Glu His Phe Phe Leu Arg Glu Pro Xaa 
                645                 650                 655     


Ala Leu Tyr Val Gln Glu Ser Val Ala Val Leu Tyr Ile Val Arg Glu 
            660                 665                 670         


Pro Ala Gln Gly Leu Phe Gly Xaa Val Xaa Val Gln Phe Ile Val Xaa 
        675                 680                 685             


Glu Val Asn Ser Ser Asn Glu Ser Lys Asp Leu Xaa Pro Ser Lys Gly 
    690                 695                 700                 


Tyr Ile Val Leu Glu Glu Gly Val Arg Phe Lys Ala Leu Gln Ile Ser 
705                 710                 715                 720 


Ala Ile Leu Asp Xaa Glu Pro Glu Met Asp Glu Tyr Phe Val Cys Xaa 
                725                 730                 735     


Leu Phe Asn Pro Xaa Gly Gly Ala Arg Leu Gly Val His Val Gln Xaa 
            740                 745                 750         


Leu Ile Xaa Val Leu Gln Asn Gln Ala Pro Leu Gly Leu Phe Ser Ile 
        755                 760                 765             


Ser Ala Val Glu Asn Arg Ala Xaa Ser Ile Asp Ile Glu Glu Ala Asn 
    770                 775                 780                 


Arg Xaa Val Tyr Leu Asn Val Ser Arg Xaa Asn Gly Ile Asp Leu Ala 
785                 790                 795                 800 


Val Ser Val Gln Trp Glu Xaa Val Ser Glu Xaa Ala Phe Gly Met Arg 
                805                 810                 815     


Gly Met Asp Val Val Phe Ser Val Phe Gln Ser Phe Leu Asp Glu Ser 
            820                 825                 830         


Ala Ser Gly Trp Cys Phe Phe Xaa Leu Glu Asn Leu Ile Tyr Gly Ile 
        835                 840                 845             


Met Leu Arg Lys Ser Ser Val Xaa Val Tyr Arg Trp Gln Gly Ile Phe 
    850                 855                 860                 


Ile Pro Val Glu Asp Leu Asn Ile Glu Asn Pro Lys Xaa Cys Glu Ala 
865                 870                 875                 880 


Phe Asn Ile Gly Phe Ser Pro Tyr Phe Val Ile Xaa His Glu Glu Arg 
                885                 890                 895     


Asn Glu Glu Lys Pro Ser Leu Asn Ser Val Phe Xaa Phe Xaa Ser Gly 
            900                 905                 910         


Phe Lys Leu Phe Leu Val Gln Xaa Ile Ile Ile Leu Glu Ser Ser Gln 
        915                 920                 925             


Val Arg Tyr Phe Xaa Ser Asp Ser Gln Asp Tyr Leu Ile Ile Ala Ser 
    930                 935                 940                 


Gln Arg Asp Asp Ser Glu Leu Xaa Gln Val Phe Arg Trp Asn Gly Gly 
945                 950                 955                 960 


Ser Phe Val Leu His Gln Lys Leu Pro Val Arg Gly Val Leu Xaa Val 
                965                 970                 975     


Ala Leu Phe Asn Lys Gly Gly Ser Val Phe Leu Ala Ile Ser Gln Ala 
            980                 985                 990         


Asn Ala Arg Leu Asn Ser Leu Leu  Phe Arg Trp Ser Gly  Ser Gly Phe 
        995                 1000                 1005             


Ile Asn  Phe Gln Glu Val Pro  Val Ser Gly Xaa Xaa  Glu Val Glu 
    1010                 1015                 1020             


Ala Leu  Ser Ser Ala Asn Asp  Ile Tyr Leu Ile Phe  Ala Glu Asn 
    1025                 1030                 1035             


Val Phe  Leu Gly Asp Gln Asn  Ser Ile Asp Ile Phe  Ile Trp Glu 
    1040                 1045                 1050             


Met Gly  Gln Ser Ser Phe Arg  Tyr Phe Gln Ser Val  Asp Phe Ala 
    1055                 1060                 1065             


Ala Val  Asn Arg Ile His Ser  Phe Xaa Pro Ala Ser  Gly Ile Ala 
    1070                 1075                 1080             


His Ile  Leu Leu Ile Gly Gln  Asp Met Ser Ala Leu  Tyr Cys Trp 
    1085                 1090                 1095             


Asn Ser  Glu Arg Asn Gln Phe  Ser Phe Val Leu Glu  Val Pro Ser 
    1100                 1105                 1110             


Ala Tyr  Asp Val Ala Ser Val  Xaa Val Lys Ser Leu  Asn Ser Ser 
    1115                 1120                 1125             


Lys Asn  Leu Ile Ala Leu Val  Gly Ala His Ser His  Ile Tyr Glu 
    1130                 1135                 1140             


Leu Ala  Tyr Ile Ser Ser His  Ser Asp Phe Ile Pro  Ser Ser Gly 
    1145                 1150                 1155             


Glu Leu  Ile Phe Glu Pro Gly  Glu Arg Glu Ala Xaa  Ile Ala Val 
    1160                 1165                 1170             


Asn Ile  Leu Asp Asp Xaa Val  Pro Glu Lys Glu Glu  Ser Phe Lys 
    1175                 1180                 1185             


Val Gln  Leu Lys Asn Pro Lys  Gly Gly Ala Glu Ile  Gly Ile Asn 
    1190                 1195                 1200             


Asp Ser  Val Xaa Ile Xaa Ile  Leu Ser Asn Asp Asp  Ala Tyr Gly 
    1205                 1210                 1215             


Ile Val  Ala Phe Ala Gln Asn  Ser Leu Tyr Lys Gln  Val Glu Glu 
    1220                 1225                 1230             


Met Glu  Gln Asp Ser Leu Val  Xaa Leu Asn Val Glu  Arg Leu Lys 
    1235                 1240                 1245             


Gly Xaa  Tyr Gly Arg Ile Xaa  Ile Ala Trp Glu Ala  Asp Gly Ser 
    1250                 1255                 1260             


Ile Ser  Asp Ile Phe Pro Xaa  Ser Gly Val Ile Leu  Phe Xaa Glu 
    1265                 1270                 1275             


Gly Gln  Val Leu Ser Xaa Ile  Xaa Leu Xaa Ile Leu  Ala Asp Asn 
    1280                 1285                 1290             


Ile Pro  Glu Leu Ser Glu Val  Val Ile Val Xaa Leu  Xaa Arg Ile 
    1295                 1300                 1305             


Xaa Xaa  Glu Gly Val Glu Asp  Ser Tyr Lys Gly Ala  Xaa Ile Asp 
    1310                 1315                 1320             


Gln Asp  Arg Ser Lys Ser Val  Ile Xaa Xaa Leu Pro  Asn Asp Ser 
    1325                 1330                 1335             


Pro Phe  Gly Leu Val Gly Trp  Arg Ala Ala Ser Val  Phe Ile Arg 
    1340                 1345                 1350             


Val Ala  Glu Pro Lys Glu Asn  Xaa Xaa Xaa Leu Gln  Leu Gln Ile 
    1355                 1360                 1365             


Ala Arg  Asp Lys Gly Leu Leu  Gly Asp Ile Ala Ile  His Leu Arg 
    1370                 1375                 1380             


Ala Gln  Pro Asn Phe Leu Leu  His Val Asp Asn Gln  Ala Xaa Glu 
    1385                 1390                 1395             


Asn Glu  Asp Tyr Val Leu Gln  Glu Xaa Ile Ile Ile  Met Lys Glu 
    1400                 1405                 1410             


Asn Ile  Lys Glu Ala His Ala  Glu Val Ser Ile Leu  Pro Asp Asp 
    1415                 1420                 1425             


Leu Pro  Glu Leu Glu Glu Gly  Phe Ile Val Xaa Ile  Xaa Glu Val 
    1430                 1435                 1440             


Asn Leu  Val Asn Ser Asp Phe  Ser Xaa Gly Gln Pro  Ser Val Arg 
    1445                 1450                 1455             


Arg Pro  Gly Met Glu Ile Ala  Glu Ile Met Ile Glu  Glu Asn Asp 
    1460                 1465                 1470             


Asp Pro  Arg Gly Ile Phe Met  Phe His Val Xaa Arg  Gly Ala Gly 
    1475                 1480                 1485             


Glu Val  Ile Xaa Ala Tyr Glu  Val Pro Pro Pro Leu  Asn Val Leu 
    1490                 1495                 1500             


Gln Val  Pro Val Val Arg Leu  Ala Gly Ser Phe Gly  Ala Val Asn 
    1505                 1510                 1515             


Val Tyr  Trp Lys Ala Ser Pro  Asp Ser Ala Gly Leu  Glu Asp Phe 
    1520                 1525                 1530             


Lys Pro  Ser His Gly Ile Leu  Glu Phe Ala Asp Lys  Gln Val Xaa 
    1535                 1540                 1545             


Ala Met  Ile Glu Ile Xaa Ile  Ile Asp Asp Ala Glu  Phe Glu Leu 
    1550                 1555                 1560             


Xaa Glu  Xaa Phe Asn Ile Ser  Leu Ile Ser Val Ala  Gly Gly Gly 
    1565                 1570                 1575             


Arg Leu  Gly Asp Asp Val Val  Val Xaa Val Val Ile  Pro Gln Asn 
    1580                 1585                 1590             


Asp Ser  Pro Phe Gly Val Phe  Gly Phe Glu Glu Lys  Xaa Val Ser 
    1595                 1600                 1605             


<210> 1793
<211> 1055
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<400> 1793
Xaa Arg Tyr Glu Glu Ile Xaa Val Val Arg Asn Gly Gly Xaa His Gly 
1               5                   10                  15      


Asn Val Ser Ala Asn Trp Val Leu Xaa Arg Asn Ser Xaa Asp Pro Ser 
            20                  25                  30          


Pro Val Xaa Ala Asp Ile Arg Pro Ser Ser Gly Val Leu His Phe Ala 
        35                  40                  45              


Gln Gly Gln Met Leu Ala Xaa Ile Pro Leu Xaa Val Val Asp Asp Asp 
    50                  55                  60                  


Leu Pro Glu Glu Ala Glu Ala Tyr Leu Leu Gln Ile Leu Pro His Xaa 
65                  70                  75                  80  


Ile Arg Gly Gly Ala Glu Val Ser Glu Pro Ala Glu Leu Leu Phe Tyr 
                85                  90                  95      


Ile Gln Asp Ser Asp Asp Val Tyr Gly Leu Ile Xaa Phe Phe Pro Met 
            100                 105                 110         


Glu Asn Gln Lys Ile Glu Ser Ser Pro Gly Glu Arg Tyr Leu Ser Leu 
        115                 120                 125             


Ser Phe Xaa Arg Leu Gly Gly Xaa Lys Gly Asp Val Arg Leu Leu Tyr 
    130                 135                 140                 


Ser Val Leu Tyr Ile Pro Ala Gly Ala Val Asp Pro Leu Gln Ala Lys 
145                 150                 155                 160 


Glu Gly Ile Leu Asn Ile Ser Arg Arg Asn Asp Leu Ile Phe Pro Glu 
                165                 170                 175     


Gln Lys Xaa Gln Val Xaa Xaa Lys Leu Pro Ile Arg Asn Asp Ala Phe 
            180                 185                 190         


Leu Gln Asn Gly Ala His Phe Leu Val Gln Leu Glu Xaa Val Glu Leu 
        195                 200                 205             


Leu Asn Ile Ile Pro Leu Ile Pro Pro Ile Ser Pro Arg Phe Gly Glu 
    210                 215                 220                 


Ile Cys Asn Ile Ser Leu Leu Val Xaa Pro Ala Ile Ala Asn Gly Glu 
225                 230                 235                 240 


Ile Gly Phe Leu Ser Asn Leu Pro Ile Ile Leu His Glu Pro Glu Asp 
                245                 250                 255     


Phe Ala Ala Glu Val Val Tyr Ile Pro Leu His Arg Asp Gly Xaa Asp 
            260                 265                 270         


Gly Gln Ala Xaa Val Tyr Trp Ser Leu Lys Pro Ser Gly Phe Asn Ser 
        275                 280                 285             


Lys Ala Val Xaa Pro Asp Asp Ile Gly Pro Phe Asn Gly Ser Val Leu 
    290                 295                 300                 


Phe Leu Ser Gly Gln Ser Asp Xaa Xaa Ile Asn Ile Xaa Ile Lys Gly 
305                 310                 315                 320 


Asp Asp Ile Pro Glu Met Asn Glu Xaa Val Xaa Leu Ser Leu Asp Arg 
                325                 330                 335     


Val Asn Val Glu Asn Gln Val Leu Lys Ser Gly Tyr Xaa Ser Arg Asp 
            340                 345                 350         


Leu Ile Ile Leu Glu Asn Asp Asp Pro Gly Gly Val Phe Glu Phe Ser 
        355                 360                 365             


Pro Ala Ser Arg Gly Pro Tyr Val Ile Lys Glu Gly Glu Ser Val Glu 
    370                 375                 380                 


Leu His Ile Ile Arg Ser Arg Gly Ser Leu Val Lys Gln Phe Leu His 
385                 390                 395                 400 


Tyr Arg Val Glu Pro Arg Asp Ser Asn Glu Phe Tyr Gly Asn Xaa Gly 
                405                 410                 415     


Val Leu Glu Phe Lys Pro Gly Glu Arg Glu Ile Val Ile Xaa Leu Leu 
            420                 425                 430         


Ala Arg Leu Asp Gly Ile Pro Glu Leu Asp Glu His Tyr Trp Val Val 
        435                 440                 445             


Leu Ser Ser His Gly Glu Arg Glu Ser Lys Leu Gly Ser Ala Xaa Ile 
    450                 455                 460                 


Val Asn Ile Xaa Ile Leu Lys Asn Asp Asp Pro His Gly Ile Ile Glu 
465                 470                 475                 480 


Phe Val Ser Asp Gly Leu Ile Val Met Ile Asn Glu Ser Lys Gly Asp 
                485                 490                 495     


Ala Ile Tyr Ser Ala Val Tyr Asp Val Val Arg Asn Arg Gly Asn Phe 
            500                 505                 510         


Gly Asp Val Ser Val Ser Trp Val Val Ser Pro Asp Phe Xaa Gln Asp 
        515                 520                 525             


Val Phe Pro Val Gln Gly Xaa Val Val Phe Gly Asp Gln Glu Phe Ser 
    530                 535                 540                 


Lys Asn Ile Xaa Ile Tyr Ser Leu Pro Asp Glu Ile Pro Glu Glu Met 
545                 550                 555                 560 


Glu Glu Phe Xaa Val Ile Leu Leu Asn Gly Xaa Gly Gly Ala Lys Val 
                565                 570                 575     


Gly Asn Arg Xaa Xaa Ala Xaa Leu Arg Ile Arg Arg Asn Asp Asp Pro 
            580                 585                 590         


Ile Tyr Phe Ala Glu Pro Arg Val Val Arg Val Gln Glu Gly Glu Xaa 
        595                 600                 605             


Ala Asn Phe Xaa Val Leu Arg Asn Gly Ser Val Asp Val Xaa Cys Met 
    610                 615                 620                 


Val Gln Tyr Ala Xaa Lys Asp Gly Lys Ala Xaa Ala Arg Glu Arg Asp 
625                 630                 635                 640 


Phe Ile Pro Val Glu Lys Gly Glu Xaa Leu Ile Phe Glu Val Gly Ser 
                645                 650                 655     


Arg Gln Gln Ser Ile Ser Ile Phe Val Asn Glu Asp Gly Ile Pro Glu 
            660                 665                 670         


Xaa Asp Glu Pro Phe Tyr Ile Ile Leu Leu Asn Ser Xaa Gly Asp Xaa 
        675                 680                 685             


Val Val Tyr Gln Tyr Gly Val Ala Xaa Val Ile Ile Glu Ala Asn Asp 
    690                 695                 700                 


Asp Pro Asn Gly Ile Phe Ser Leu Glu Pro Ile Asp Lys Ala Val Glu 
705                 710                 715                 720 


Glu Gly Lys Xaa Asn Ala Phe Trp Ile Leu Arg His Arg Gly Tyr Phe 
                725                 730                 735     


Gly Ser Val Ser Val Ser Trp Gln Leu Phe Gln Asn Asp Ser Ala Leu 
            740                 745                 750         


Gln Pro Gly Gln Glu Phe Tyr Glu Xaa Ser Gly Xaa Val Asn Phe Met 
        755                 760                 765             


Asp Gly Glu Glu Ala Lys Pro Ile Ile Leu His Ala Phe Pro Asp Lys 
    770                 775                 780                 


Ile Pro Glu Phe Asn Glu Phe Tyr Phe Leu Lys Leu Val Asn Ile Ser 
785                 790                 795                 800 


Gly Gly Ser Pro Gly Pro Gly Gly Gln Leu Ala Glu Xaa Asn Leu Gln 
                805                 810                 815     


Val Xaa Val Met Val Pro Phe Asn Asp Asp Pro Phe Gly Val Phe Ile 
            820                 825                 830         


Leu Asp Pro Glu Cys Leu Glu Arg Glu Val Ala Glu Asp Val Leu Ser 
        835                 840                 845             


Glu Asp Asp Met Ser Tyr Ile Xaa Asn Phe Xaa Ile Leu Arg Gln Gln 
    850                 855                 860                 


Gly Val Phe Gly Asp Val Gln Leu Gly Trp Glu Ile Leu Ser Ser Glu 
865                 870                 875                 880 


Phe Pro Ala Gly Leu Pro Pro Met Ile Asp Phe Leu Leu Val Gly Ile 
                885                 890                 895     


Phe Pro Xaa Xaa Val His Leu Gln Gln His Met Arg Arg His His Ser 
            900                 905                 910         


Gly Xaa Asp Ala Leu Tyr Phe Xaa Gly Leu Glu Gly Ala Phe Gly Xaa 
        915                 920                 925             


Val Asn Pro Lys Tyr His Pro Ser Arg Asn Asn Xaa Ile Ala Asn Phe 
    930                 935                 940                 


Xaa Phe Ser Ala Trp Val Met Pro Asn Ala Asn Xaa Asn Gly Phe Ile 
945                 950                 955                 960 


Ile Ala Lys Asp Asp Gly Asn Gly Ser Ile Tyr Tyr Gly Val Lys Ile 
                965                 970                 975     


Gln Xaa Asn Glu Ser His Val Xaa Leu Ser Leu His Tyr Lys Xaa Leu 
            980                 985                 990         


Gly Ser Asn Ala Xaa Tyr Ile Ala  Lys Xaa Xaa Val Met  Lys Tyr Leu 
        995                 1000                 1005             


Glu Glu  Ser Val Trp Leu His  Leu Leu Ile Ile Leu  Glu Asp Gly 
    1010                 1015                 1020             


Ile Ile  Glu Phe Tyr Leu Asp  Gly Asn Ala Met Pro  Arg Gly Ile 
    1025                 1030                 1035             


Lys Ser  Leu Lys Gly Glu Ala  Ile Xaa Asp Gly Glu  Gly His His 
    1040                 1045                 1050             


His Asn  
    1055 


<210> 1794
<211> 386
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<400> 1794
Met Phe Ala Glu Ile Gln Ile Gln Asp Lys Asp Arg Met Gly Xaa Ala 
1               5                   10                  15      


Gly Lys Val Ile Lys Cys Lys Ala Ala Val Leu Trp Glu Gln Lys Gln 
            20                  25                  30          


Pro Phe Ser Ile Glu Glu Ile Glu Val Ala Pro Pro Lys Xaa Lys Glu 
        35                  40                  45              


Val Arg Ile Lys Ile Leu Ala Xaa Gly Ile Cys Arg Xaa Asp Asp His 
    50                  55                  60                  


Val Ile Lys Gly Xaa Met Val Ser Lys Phe Pro Val Ile Val Gly His 
65                  70                  75                  80  


Glu Ala Xaa Gly Ile Val Glu Ser Ile Gly Glu Gly Val Xaa Xaa Val 
                85                  90                  95      


Lys Pro Gly Asp Lys Val Ile Pro Leu Phe Leu Pro Gln Cys Arg Glu 
            100                 105                 110         


Cys Asn Ala Cys Arg Asn Pro Asp Gly Asn Leu Cys Ile Arg Ser Asp 
        115                 120                 125             


Ile Xaa Gly Arg Gly Val Leu Ala Asp Gly Xaa Xaa Arg Phe Xaa Cys 
    130                 135                 140                 


Lys Gly Lys Pro Val His His Phe Met Asn Xaa Ser Xaa Phe Xaa Glu 
145                 150                 155                 160 


Tyr Xaa Val Val Asp Glu Ser Ser Val Ala Lys Ile Asp Asp Ala Ala 
                165                 170                 175     


Pro Pro Glu Lys Val Cys Leu Ile Gly Cys Gly Phe Ser Xaa Gly Tyr 
            180                 185                 190         


Gly Ala Ala Val Lys Xaa Gly Lys Val Lys Pro Gly Ser Xaa Cys Val 
        195                 200                 205             


Val Phe Gly Leu Gly Gly Val Gly Leu Ser Val Ile Met Gly Cys Lys 
    210                 215                 220                 


Ser Ala Gly Ala Ser Arg Ile Ile Gly Ile Asp Leu Asn Lys Asp Lys 
225                 230                 235                 240 


Phe Glu Lys Ala Met Ala Val Gly Ala Xaa Glu Cys Ile Ser Pro Lys 
                245                 250                 255     


Asp Ser Xaa Lys Pro Ile Ser Glu Val Leu Ser Glu Met Xaa Gly Asn 
            260                 265                 270         


Asn Val Gly Tyr Xaa Phe Glu Val Ile Gly His Leu Glu Xaa Met Ile 
        275                 280                 285             


Asp Ala Leu Ala Ser Cys His Met Asn Tyr Gly Xaa Ser Val Val Val 
    290                 295                 300                 


Gly Val Pro Pro Ser Ala Lys Met Leu Xaa Tyr Asp Pro Met Leu Leu 
305                 310                 315                 320 


Phe Xaa Gly Arg Xaa Trp Lys Gly Cys Val Phe Gly Gly Leu Lys Ser 
                325                 330                 335     


Arg Asp Asp Val Pro Lys Leu Val Xaa Glu Phe Leu Ala Lys Lys Phe 
            340                 345                 350         


Asp Leu Asp Gln Leu Ile Xaa His Val Leu Pro Phe Lys Lys Ile Ser 
        355                 360                 365             


Glu Gly Phe Glu Leu Leu Asn Ser Gly Gln Ser Ile Arg Xaa Val Leu 
    370                 375                 380                 


Xaa Phe 
385     


<210> 1795
<211> 374
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<400> 1795
Met Gly Xaa Ala Gly Lys Val Ile Lys Cys Lys Ala Ala Val Leu Trp 
1               5                   10                  15      


Glu Gln Lys Gln Pro Phe Ser Ile Glu Glu Ile Glu Val Ala Pro Pro 
            20                  25                  30          


Lys Xaa Lys Glu Val Arg Ile Lys Ile Leu Ala Xaa Gly Ile Cys Arg 
        35                  40                  45              


Xaa Asp Asp His Val Ile Lys Gly Xaa Met Val Ser Lys Phe Pro Val 
    50                  55                  60                  


Ile Val Gly His Glu Ala Xaa Gly Ile Val Glu Ser Ile Gly Glu Gly 
65                  70                  75                  80  


Val Xaa Xaa Val Lys Pro Gly Asp Lys Val Ile Pro Leu Phe Leu Pro 
                85                  90                  95      


Gln Cys Arg Glu Cys Asn Ala Cys Arg Asn Pro Asp Gly Asn Leu Cys 
            100                 105                 110         


Ile Arg Ser Asp Ile Xaa Gly Arg Gly Val Leu Ala Asp Gly Xaa Xaa 
        115                 120                 125             


Arg Phe Xaa Cys Lys Gly Lys Pro Val His His Phe Met Asn Xaa Ser 
    130                 135                 140                 


Xaa Phe Xaa Glu Tyr Xaa Val Val Asp Glu Ser Ser Val Ala Lys Ile 
145                 150                 155                 160 


Asp Asp Ala Ala Pro Pro Glu Lys Val Cys Leu Ile Gly Cys Gly Phe 
                165                 170                 175     


Ser Xaa Gly Tyr Gly Ala Ala Val Lys Xaa Gly Lys Val Lys Pro Gly 
            180                 185                 190         


Ser Xaa Cys Val Val Phe Gly Leu Gly Gly Val Gly Leu Ser Val Ile 
        195                 200                 205             


Met Gly Cys Lys Ser Ala Gly Ala Ser Arg Ile Ile Gly Ile Asp Leu 
    210                 215                 220                 


Asn Lys Asp Lys Phe Glu Lys Ala Met Ala Val Gly Ala Xaa Glu Cys 
225                 230                 235                 240 


Ile Ser Pro Lys Asp Ser Xaa Lys Pro Ile Ser Glu Val Leu Ser Glu 
                245                 250                 255     


Met Xaa Gly Asn Asn Val Gly Tyr Xaa Phe Glu Val Ile Gly His Leu 
            260                 265                 270         


Glu Xaa Met Ile Asp Ala Leu Ala Ser Cys His Met Asn Tyr Gly Xaa 
        275                 280                 285             


Ser Val Val Val Gly Val Pro Pro Ser Ala Lys Met Leu Xaa Tyr Asp 
    290                 295                 300                 


Pro Met Leu Leu Phe Xaa Gly Arg Xaa Trp Lys Gly Cys Val Phe Gly 
305                 310                 315                 320 


Gly Leu Lys Ser Arg Asp Asp Val Pro Lys Leu Val Xaa Glu Phe Leu 
                325                 330                 335     


Ala Lys Lys Phe Asp Leu Asp Gln Leu Ile Xaa His Val Leu Pro Phe 
            340                 345                 350         


Lys Lys Ile Ser Glu Gly Phe Glu Leu Leu Asn Ser Gly Gln Ser Ile 
        355                 360                 365             


Arg Xaa Val Leu Xaa Phe 
    370                 


<210> 1796
<211> 394
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<400> 1796
Met Lys Cys Leu Val Ser Arg His Xaa Val Arg Glu Xaa Leu Asp Met 
1               5                   10                  15      


Val Phe Gln Arg Met Ser Val Glu Ala Gly Val Ile Lys Cys Lys Ala 
            20                  25                  30          


Ala Val Leu Trp Glu Gln Lys Gln Pro Phe Ser Ile Glu Glu Ile Glu 
        35                  40                  45              


Val Ala Pro Pro Lys Xaa Lys Glu Val Arg Ile Lys Ile Leu Ala Xaa 
    50                  55                  60                  


Gly Ile Cys Arg Xaa Asp Asp His Val Ile Lys Gly Xaa Met Val Ser 
65                  70                  75                  80  


Lys Phe Pro Val Ile Val Gly His Glu Ala Xaa Gly Ile Val Glu Ser 
                85                  90                  95      


Ile Gly Glu Gly Val Xaa Xaa Val Lys Pro Gly Asp Lys Val Ile Pro 
            100                 105                 110         


Leu Phe Leu Pro Gln Cys Arg Glu Cys Asn Ala Cys Arg Asn Pro Asp 
        115                 120                 125             


Gly Asn Leu Cys Ile Arg Ser Asp Ile Xaa Gly Arg Gly Val Leu Ala 
    130                 135                 140                 


Asp Gly Xaa Xaa Arg Phe Xaa Cys Lys Gly Lys Pro Val His His Phe 
145                 150                 155                 160 


Met Asn Xaa Ser Xaa Phe Xaa Glu Tyr Xaa Val Val Asp Glu Ser Ser 
                165                 170                 175     


Val Ala Lys Ile Asp Asp Ala Ala Pro Pro Glu Lys Val Cys Leu Ile 
            180                 185                 190         


Gly Cys Gly Phe Ser Xaa Gly Tyr Gly Ala Ala Val Lys Xaa Gly Lys 
        195                 200                 205             


Val Lys Pro Gly Ser Xaa Cys Val Val Phe Gly Leu Gly Gly Val Gly 
    210                 215                 220                 


Leu Ser Val Ile Met Gly Cys Lys Ser Ala Gly Ala Ser Arg Ile Ile 
225                 230                 235                 240 


Gly Ile Asp Leu Asn Lys Asp Lys Phe Glu Lys Ala Met Ala Val Gly 
                245                 250                 255     


Ala Xaa Glu Cys Ile Ser Pro Lys Asp Ser Xaa Lys Pro Ile Ser Glu 
            260                 265                 270         


Val Leu Ser Glu Met Xaa Gly Asn Asn Val Gly Tyr Xaa Phe Glu Val 
        275                 280                 285             


Ile Gly His Leu Glu Xaa Met Ile Asp Ala Leu Ala Ser Cys His Met 
    290                 295                 300                 


Asn Tyr Gly Xaa Ser Val Val Val Gly Val Pro Pro Ser Ala Lys Met 
305                 310                 315                 320 


Leu Xaa Tyr Asp Pro Met Leu Leu Phe Xaa Gly Arg Xaa Trp Lys Gly 
                325                 330                 335     


Cys Val Phe Gly Gly Leu Lys Ser Arg Asp Asp Val Pro Lys Leu Val 
            340                 345                 350         


Xaa Glu Phe Leu Ala Lys Lys Phe Asp Leu Asp Gln Leu Ile Xaa His 
        355                 360                 365             


Val Leu Pro Phe Lys Lys Ile Ser Glu Gly Phe Glu Leu Leu Asn Ser 
    370                 375                 380                 


Gly Gln Ser Ile Arg Xaa Val Leu Xaa Phe 
385                 390                 


<210> 1797
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<400> 1797
Met Val Ser Lys Phe Pro Val Ile Val Gly His Glu Ala Xaa Gly Ile 
1               5                   10                  15      


Val Glu Ser Ile Gly Glu Gly Val Xaa Xaa Val Lys Pro Gly Asp Lys 
            20                  25                  30          


Val Ile Pro Leu Phe Leu Pro Gln Cys Arg Glu Cys Asn Ala Cys Arg 
        35                  40                  45              


Asn Pro Asp Gly Asn Leu Cys Ile Arg Ser Asp Ile Xaa Gly Arg Gly 
    50                  55                  60                  


Val Leu Ala Asp Gly Xaa Xaa Arg Phe Xaa Cys Lys Gly Lys Pro Val 
65                  70                  75                  80  


His His Phe Met Asn Xaa Ser Xaa Phe Xaa Glu Tyr Xaa Val Val Asp 
                85                  90                  95      


Glu Ser Ser Val Ala Lys Ile Asp Asp Ala Ala Pro 
            100                 105             


<210> 1798
<211> 317
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<400> 1798
Met Val Ser Lys Phe Pro Val Ile Val Gly His Glu Ala Xaa Gly Ile 
1               5                   10                  15      


Val Glu Ser Ile Gly Glu Gly Val Xaa Xaa Val Lys Pro Gly Asp Lys 
            20                  25                  30          


Val Ile Pro Leu Phe Leu Pro Gln Cys Arg Glu Cys Asn Ala Cys Arg 
        35                  40                  45              


Asn Pro Asp Gly Asn Leu Cys Ile Arg Ser Asp Ile Xaa Gly Arg Gly 
    50                  55                  60                  


Val Leu Ala Asp Gly Xaa Xaa Arg Phe Xaa Cys Lys Gly Lys Pro Val 
65                  70                  75                  80  


His His Phe Met Asn Xaa Ser Xaa Phe Xaa Glu Tyr Xaa Val Val Asp 
                85                  90                  95      


Glu Ser Ser Val Ala Lys Ile Asp Asp Ala Ala Pro Pro Glu Lys Val 
            100                 105                 110         


Cys Leu Ile Gly Cys Gly Phe Ser Xaa Gly Tyr Gly Ala Ala Val Lys 
        115                 120                 125             


Xaa Gly Lys Val Lys Pro Gly Ser Xaa Cys Val Val Phe Gly Leu Gly 
    130                 135                 140                 


Gly Val Gly Leu Ser Val Ile Met Gly Cys Lys Ser Ala Gly Ala Ser 
145                 150                 155                 160 


Arg Ile Ile Gly Ile Asp Leu Asn Lys Asp Lys Phe Glu Lys Ala Met 
                165                 170                 175     


Ala Val Gly Ala Xaa Glu Cys Ile Ser Pro Lys Asp Ser Xaa Lys Pro 
            180                 185                 190         


Ile Ser Glu Val Leu Ser Glu Met Xaa Gly Asn Asn Val Gly Tyr Xaa 
        195                 200                 205             


Phe Glu Val Ile Gly His Leu Glu Xaa Met Ile Asp Ala Leu Ala Ser 
    210                 215                 220                 


Cys His Met Asn Tyr Gly Xaa Ser Val Val Val Gly Val Pro Pro Ser 
225                 230                 235                 240 


Ala Lys Met Leu Xaa Tyr Asp Pro Met Leu Leu Phe Xaa Gly Arg Xaa 
                245                 250                 255     


Trp Lys Gly Cys Val Phe Gly Gly Leu Lys Ser Arg Asp Asp Val Pro 
            260                 265                 270         


Lys Leu Val Xaa Glu Phe Leu Ala Lys Lys Phe Asp Leu Asp Gln Leu 
        275                 280                 285             


Ile Xaa His Val Leu Pro Phe Lys Lys Ile Ser Glu Gly Phe Glu Leu 
    290                 295                 300                 


Leu Asn Ser Gly Gln Ser Ile Arg Xaa Val Leu Xaa Phe 
305                 310                 315         


<210> 1799
<211> 244
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<400> 1799
Met Leu Leu Leu Gly Ala Val Leu Leu Leu Leu Ala Leu Pro Gly His 
1               5                   10                  15      


Asp Gln Glu Xaa Xaa Xaa Gln Gly Pro Gly Val Leu Leu Pro Leu Pro 
            20                  25                  30          


Lys Gly Ala Cys Xaa Gly Trp Met Ala Gly Ile Pro Gly His Pro Gly 
        35                  40                  45              


His Asn Gly Ala Pro Gly Arg Asp Gly Arg Asp Gly Xaa Pro Gly Glu 
    50                  55                  60                  


Lys Gly Glu Lys Gly Asp Pro Gly Leu Ile Gly Pro Lys Gly Asp Ile 
65                  70                  75                  80  


Gly Glu Xaa Gly Val Pro Gly Ala Glu Gly Pro Arg Gly Phe Pro Gly 
                85                  90                  95      


Ile Gln Gly Arg Lys Gly Glu Pro Gly Glu Gly Ala Tyr Val Tyr Arg 
            100                 105                 110         


Ser Ala Phe Ser Val Gly Leu Glu Xaa Tyr Val Xaa Ile Pro Asn Met 
        115                 120                 125             


Pro Ile Arg Phe Xaa Lys Ile Phe Tyr Asn Gln Gln Asn His Tyr Asp 
    130                 135                 140                 


Gly Ser Xaa Gly Lys Phe His Cys Asn Ile Pro Gly Leu Tyr Tyr Phe 
145                 150                 155                 160 


Ala Tyr His Ile Xaa Val Tyr Met Lys Asp Val Lys Val Ser Leu Phe 
                165                 170                 175     


Lys Lys Asp Lys Ala Met Leu Phe Xaa Tyr Asp Gln Tyr Gln Glu Asn 
            180                 185                 190         


Asn Val Asp Gln Ala Ser Gly Ser Val Leu Leu His Leu Glu Val Gly 
        195                 200                 205             


Asp Gln Val Trp Leu Gln Val Tyr Gly Glu Gly Glu Arg Asn Gly Leu 
    210                 215                 220                 


Tyr Ala Asp Asn Asp Asn Asp Ser Xaa Phe Xaa Gly Phe Leu Leu Tyr 
225                 230                 235                 240 


His Asp Xaa Asn 
                


<210> 1800
<211> 171
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<400> 1800
Met Ser Ser His Lys Gly Ser Val Val Ala Gln Gly Asn Gly Ala Pro 
1               5                   10                  15      


Ala Ser Asn Arg Glu Ala Asp Xaa Val Glu Leu Ala Glu Leu Gly Pro 
            20                  25                  30          


Leu Leu Glu Glu Lys Gly Lys Arg Val Ile Ala Asn Pro Pro Lys Ala 
        35                  40                  45              


Glu Glu Glu Gln Xaa Cys Pro Val Pro Gln Glu Glu Glu Glu Glu Val 
    50                  55                  60                  


Arg Val Leu Xaa Leu Pro Leu Gln Ala His His Ala Met Glu Lys Met 
65                  70                  75                  80  


Glu Glu Phe Val Tyr Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro 
                85                  90                  95      


Tyr Asp Val Leu Pro Asp Trp Leu Lys Asp Asn Asp Tyr Leu Leu His 
            100                 105                 110         


Gly His Arg Pro Pro Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile 
        115                 120                 125             


Phe Arg Ile His Xaa Glu Xaa Gly Asn Ile Trp Xaa His Leu Leu Ala 
    130                 135                 140                 


Xaa Ala His Leu Pro Leu His Arg Leu Cys Pro Gly His Phe Cys His 
145                 150                 155                 160 


His Cys Gly Ala Val Gly Pro Val Cys His Ser 
                165                 170     


<210> 1801
<211> 205
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<400> 1801
Met Ser Ser His Lys Gly Ser Val Val Ala Gln Gly Asn Gly Ala Pro 
1               5                   10                  15      


Ala Ser Asn Arg Glu Ala Asp Xaa Val Glu Leu Ala Glu Leu Gly Pro 
            20                  25                  30          


Leu Leu Glu Glu Lys Gly Lys Arg Val Ile Ala Asn Pro Pro Lys Ala 
        35                  40                  45              


Glu Glu Glu Gln Xaa Cys Pro Val Pro Gln Glu Glu Glu Glu Glu Val 
    50                  55                  60                  


Arg Val Leu Xaa Leu Pro Leu Gln Ala His His Ala Met Glu Lys Met 
65                  70                  75                  80  


Glu Glu Phe Val Tyr Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro 
                85                  90                  95      


Tyr Asp Val Leu Pro Asp Trp Leu Lys Asp Asn Asp Tyr Leu Leu His 
            100                 105                 110         


Gly His Arg Pro Pro Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile 
        115                 120                 125             


Phe Arg Ile His Xaa Glu Xaa Gly Asn Ile Trp Xaa His Leu Leu Gly 
    130                 135                 140                 


Phe Val Leu Phe Leu Phe Leu Gly Ile Leu Xaa Met Leu Arg Pro Asn 
145                 150                 155                 160 


Met Tyr Phe Met Ala Pro Leu Gln Glu Lys Val Val Phe Gly Met Phe 
                165                 170                 175     


Phe Leu Gly Ala Val Leu Cys Leu Ser Phe Ser Trp Leu Phe His Xaa 
            180                 185                 190         


Val Tyr Cys His Ser Glu Lys Val Ser Arg Xaa Phe Ser 
        195                 200                 205 


<210> 1802
<211> 266
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<400> 1802
Met Ser Ser His Lys Gly Ser Val Val Ala Gln Gly Asn Gly Ala Pro 
1               5                   10                  15      


Ala Ser Asn Arg Glu Ala Asp Xaa Val Glu Leu Ala Glu Leu Gly Pro 
            20                  25                  30          


Leu Leu Glu Glu Lys Gly Lys Arg Val Ile Ala Asn Pro Pro Lys Ala 
        35                  40                  45              


Glu Glu Glu Gln Xaa Cys Pro Val Pro Gln Glu Glu Glu Glu Glu Val 
    50                  55                  60                  


Arg Val Leu Xaa Leu Pro Leu Gln Ala His His Ala Met Glu Lys Met 
65                  70                  75                  80  


Glu Glu Phe Val Tyr Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro 
                85                  90                  95      


Tyr Asp Val Leu Pro Asp Trp Leu Lys Asp Asn Asp Tyr Leu Leu His 
            100                 105                 110         


Gly His Arg Pro Pro Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile 
        115                 120                 125             


Phe Arg Ile His Xaa Glu Xaa Gly Asn Ile Trp Xaa His Leu Leu Gly 
    130                 135                 140                 


Phe Val Leu Phe Leu Phe Leu Gly Ile Leu Xaa Met Leu Arg Pro Asn 
145                 150                 155                 160 


Met Tyr Phe Met Ala Pro Leu Gln Glu Lys Val Val Phe Gly Met Phe 
                165                 170                 175     


Phe Leu Gly Ala Val Leu Cys Leu Ser Phe Ser Trp Leu Phe His Xaa 
            180                 185                 190         


Val Tyr Cys His Ser Glu Lys Val Ser Arg Xaa Phe Ser Lys Leu Asp 
        195                 200                 205             


Tyr Ser Gly Ile Ala Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu 
    210                 215                 220                 


Tyr Tyr Ser Phe Tyr Cys Ser Pro Gln Pro Arg Leu Ile Tyr Leu Ser 
225                 230                 235                 240 


Ile Val Cys Val Leu Gly Ile Ser Ala Ile Ile Val Ala Gln Trp Asp 
                245                 250                 255     


Arg Phe Ala Xaa Pro Lys His Arg Gln Xaa 
            260                 265     


<210> 1803
<211> 375
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<400> 1803
Met Ser Ser His Lys Gly Ser Val Val Ala Gln Gly Asn Gly Ala Pro 
1               5                   10                  15      


Ala Ser Asn Arg Glu Ala Asp Xaa Val Glu Leu Ala Glu Leu Gly Pro 
            20                  25                  30          


Leu Leu Glu Glu Lys Gly Lys Arg Val Ile Ala Asn Pro Pro Lys Ala 
        35                  40                  45              


Glu Glu Glu Gln Xaa Cys Pro Val Pro Gln Glu Glu Glu Glu Glu Val 
    50                  55                  60                  


Arg Val Leu Xaa Leu Pro Leu Gln Ala His His Ala Met Glu Lys Met 
65                  70                  75                  80  


Glu Glu Phe Val Tyr Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro 
                85                  90                  95      


Tyr Asp Val Leu Pro Asp Trp Leu Lys Asp Asn Asp Tyr Leu Leu His 
            100                 105                 110         


Gly His Arg Pro Pro Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile 
        115                 120                 125             


Phe Arg Ile His Xaa Glu Xaa Gly Asn Ile Trp Xaa His Leu Leu Gly 
    130                 135                 140                 


Phe Val Leu Phe Leu Phe Leu Gly Ile Leu Xaa Met Leu Arg Pro Asn 
145                 150                 155                 160 


Met Tyr Phe Met Ala Pro Leu Gln Glu Lys Val Val Phe Gly Met Phe 
                165                 170                 175     


Phe Leu Gly Ala Val Leu Cys Leu Ser Phe Ser Trp Leu Phe His Xaa 
            180                 185                 190         


Val Tyr Cys His Ser Glu Lys Val Ser Arg Xaa Phe Ser Lys Leu Asp 
        195                 200                 205             


Tyr Ser Gly Ile Ala Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu 
    210                 215                 220                 


Tyr Tyr Ser Phe Tyr Cys Ser Pro Gln Pro Arg Leu Ile Tyr Leu Ser 
225                 230                 235                 240 


Ile Val Cys Val Leu Gly Ile Ser Ala Ile Ile Val Ala Gln Trp Asp 
                245                 250                 255     


Arg Phe Ala Xaa Pro Lys His Arg Gln Xaa Arg Ala Gly Val Phe Leu 
            260                 265                 270         


Gly Leu Gly Leu Ser Gly Val Val Pro Xaa Met His Phe Xaa Ile Ala 
        275                 280                 285             


Glu Gly Phe Val Lys Ala Xaa Xaa Val Gly Gln Met Gly Trp Phe Phe 
    290                 295                 300                 


Leu Met Ala Val Met Tyr Ile Xaa Gly Ala Gly Leu Tyr Ala Ala Arg 
305                 310                 315                 320 


Ile Pro Glu Arg Phe Phe Pro Gly Lys Phe Asp Ile Trp Phe Gln Ser 
                325                 330                 335     


His Gln Ile Phe His Val Leu Val Val Ala Ala Ala Phe Val His Phe 
            340                 345                 350         


Tyr Gly Val Ser Asn Leu Gln Glu Phe Arg Tyr Gly Leu Glu Gly Gly 
        355                 360                 365             


Cys Xaa Asp Asp Xaa Leu Leu 
    370                 375 


<210> 1804
<211> 386
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<400> 1804
Met Asn Glu Pro Xaa Glu Asn Arg Leu Gly Cys Ser Arg Xaa Pro Glu 
1               5                   10                  15      


Pro Asp Ile Arg Leu Arg Lys Gly His Gln Leu Asp Gly Xaa Arg Arg 
            20                  25                  30          


Gly Asp Asn Asp Ser His Gln Gly Asp Leu Glu Pro Ile Leu Glu Ala 
        35                  40                  45              


Ser Val Leu Ser Ser His His Lys Lys Ser Ser Glu Glu His Glu Tyr 
    50                  55                  60                  


Ser Asp Glu Ala Pro Gln Glu Asp Glu Gly Phe Met Gly Met Ser Pro 
65                  70                  75                  80  


Leu Leu Gln Ala His His Ala Met Glu Lys Met Glu Glu Phe Val Cys 
                85                  90                  95      


Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro His Asp Val Leu Pro 
            100                 105                 110         


Asp Trp Leu Lys Asp Asn Asp Phe Leu Leu His Gly His Arg Pro Pro 
        115                 120                 125             


Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile Phe Arg Ile His Xaa 
    130                 135                 140                 


Glu Xaa Gly Asn Ile Trp Xaa His Leu Leu Gly Cys Val Phe Phe Leu 
145                 150                 155                 160 


Cys Leu Gly Ile Phe Tyr Met Phe Arg Pro Asn Ile Ser Phe Val Ala 
                165                 170                 175     


Pro Leu Gln Glu Lys Val Val Phe Gly Leu Phe Phe Leu Gly Ala Ile 
            180                 185                 190         


Leu Cys Leu Ser Phe Ser Trp Leu Phe His Xaa Val Tyr Cys His Ser 
        195                 200                 205             


Glu Gly Val Ser Arg Leu Phe Ser Lys Leu Asp Tyr Ser Gly Ile Ala 
    210                 215                 220                 


Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu Tyr Tyr Ser Phe Tyr 
225                 230                 235                 240 


Cys Asn Pro Gln Pro Cys Phe Ile Tyr Leu Ile Val Ile Cys Val Leu 
                245                 250                 255     


Gly Ile Ala Ala Ile Ile Val Ser Gln Trp Asp Met Phe Ala Xaa Pro 
            260                 265                 270         


Gln Tyr Arg Gly Val Arg Ala Gly Val Phe Leu Gly Leu Gly Leu Ser 
        275                 280                 285             


Gly Ile Ile Pro Xaa Leu His Tyr Val Ile Ser Glu Gly Phe Leu Lys 
    290                 295                 300                 


Ala Ala Xaa Ile Gly Gln Ile Gly Trp Leu Met Leu Met Ala Ser Leu 
305                 310                 315                 320 


Tyr Ile Xaa Gly Ala Ala Leu Tyr Ala Ala Arg Ile Pro Glu Arg Phe 
                325                 330                 335     


Phe Pro Gly Lys Cys Asp Ile Trp Phe His Ser His Gln Leu Phe His 
            340                 345                 350         


Ile Phe Val Val Ala Gly Ala Phe Val His Phe His Gly Val Ser Asn 
        355                 360                 365             


Leu Gln Glu Phe Arg Phe Met Ile Gly Gly Gly Cys Ser Glu Glu Asp 
    370                 375                 380                 


Ala Leu 
385     


<210> 1805
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<400> 1805
Met Gly Ser Gln Val Ala Phe Leu Pro Pro Pro Pro Ala Arg Ser Ser 
1               5                   10                  15      


Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg Gln Ser Met Asn 
            20                  25                  30          


Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe Gly Xaa Cys Xaa 
        35                  40                  45              


Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Xaa Asp Lys Asp Lys 
    50                  55                  60                  


Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln Gly Tyr Gly Arg 
65                  70                  75                  80  


Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly Arg Xaa Leu Val 
                85                  90                  95      


Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro Pro Ser Gly Ser 
            100                 105                 110         


Ala Pro His Phe Leu 
        115         


<210> 1806
<211> 83
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 1806
Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Xaa Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Xaa Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Xaa Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Arg 
            


<210> 1807
<211> 139
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<400> 1807
Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Xaa Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Xaa Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Xaa Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Ser Cys Leu Ser Ser Pro Ser Pro Arg Pro Gln Gln Ser Gly 
                85                  90                  95      


Cys Arg Pro His Pro Ser Gln Ala Leu Pro Pro Glu His Glu Gln Leu 
            100                 105                 110         


Pro Gly Pro Pro Glu Leu Trp Leu Pro Leu Arg Asp Val His Gly Ala 
        115                 120                 125             


Glu Ala Gly Xaa Pro Asp Leu Pro Val His Arg 
    130                 135                 


<210> 1808
<211> 185
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 1808
Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Xaa Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Xaa Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Xaa Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg 
                85                  90                  95      


Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe 
            100                 105                 110         


Gly Xaa Cys Xaa Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Xaa 
        115                 120                 125             


Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln 
    130                 135                 140                 


Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly 
145                 150                 155                 160 


Arg Xaa Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro 
                165                 170                 175     


Pro Ser Gly Ser Ala Pro His Phe Leu 
            180                 185 


<210> 1809
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 1809
Met Ser Ser Ser Tyr Pro Xaa Gly Leu Ala Asp Val Lys Ala Gly Pro 
1               5                   10                  15      


Ala Gln Xaa Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser 
            20                  25                  30          


Pro Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr 
        35                  40                  45              


Arg Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg 
    50                  55                  60                  


Phe Gly Xaa Cys Xaa Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe 
65                  70                  75                  80  


Xaa Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro 
                85                  90                  95      


Gln Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro 
            100                 105                 110         


Gly Arg Xaa Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala 
        115                 120                 125             


Pro Pro Ser Gly Ser Ala Pro His Phe Leu 
    130                 135             


<210> 1810
<211> 148
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<400> 1810
Met Ala Arg Ile Pro Xaa Ala Ala Leu Gly Cys Ile Ser Leu Leu Cys 
1               5                   10                  15      


Leu Gln Leu Pro Gly Ser Leu Ser Arg Ser Leu Gly Gly Asp Pro Arg 
            20                  25                  30          


Pro Val Lys Pro Arg Glu Pro Pro Ala Arg Ser Pro Ser Ser Ser Leu 
        35                  40                  45              


Gln Pro Arg His Pro Ala Pro Arg Pro Val Val Trp Lys Leu His Arg 
    50                  55                  60                  


Ala Leu Gln Ala Gln Arg Gly Ala Gly Leu Ala Pro Val Met Gly Gln 
65                  70                  75                  80  


Pro Leu Arg Asp Gly Gly Arg Gln His Ser Gly Pro Arg Arg His Ser 
                85                  90                  95      


Gly Pro Arg Arg Xaa Gln Ala Gln Leu Leu Arg Val Gly Cys Val Leu 
            100                 105                 110         


Gly Xaa Cys Gln Val Gln Asn Leu Ser His Arg Leu Trp Gln Leu Met 
        115                 120                 125             


Gly Pro Ala Gly Arg Gln Asp Ser Ala Pro Val Asp Pro Ser Ser Pro 
    130                 135                 140                 


His Ser Tyr Gly 
145             


<210> 1811
<211> 173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<400> 1811
Met Phe Gln Leu Pro Val Asn Asn Leu Gly Ser Leu Arg Lys Ala Arg 
1               5                   10                  15      


Lys Xaa Val Lys Lys Ile Leu Ser Asp Ile Gly Leu Glu Tyr Cys Lys 
            20                  25                  30          


Glu His Ile Glu Asp Phe Lys Gln Phe Glu Pro Asn Asp Phe Tyr Leu 
        35                  40                  45              


Lys Asn Xaa Xaa Trp Glu Asp Val Gly Leu Trp Asp Pro Ser Leu Xaa 
    50                  55                  60                  


Lys Asn Gln Asp Tyr Arg Xaa Lys Pro Phe Cys Cys Ser Ala Cys Pro 
65                  70                  75                  80  


Phe Ser Ser Lys Phe Phe Ser Ala Tyr Lys Ser His Phe Arg Asn Val 
                85                  90                  95      


His Ser Glu Asp Phe Glu Asn Arg Ile Leu Leu Asn Cys Pro Tyr Cys 
            100                 105                 110         


Xaa Phe Asn Ala Asp Lys Lys Xaa Leu Glu Xaa His Ile Lys Ile Phe 
        115                 120                 125             


His Ala Pro Asn Ala Ser Ala Pro Ser Ser Ser Leu Ser Xaa Phe Lys 
    130                 135                 140                 


Asp Lys Asn Lys Asn Asp Gly Leu Lys Pro Lys Gln Ala Asp Ser Val 
145                 150                 155                 160 


Glu Gln Ala Val Tyr Tyr Cys Lys Lys Cys Xaa Tyr Arg 
                165                 170             


<210> 1812
<211> 1102
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<400> 1812
Met Phe Gln Leu Pro Val Asn Asn Leu Gly Ser Leu Arg Lys Ala Arg 
1               5                   10                  15      


Lys Xaa Val Lys Lys Ile Leu Ser Asp Ile Gly Leu Glu Tyr Cys Lys 
            20                  25                  30          


Glu His Ile Glu Asp Phe Lys Gln Phe Glu Pro Asn Asp Phe Tyr Leu 
        35                  40                  45              


Lys Asn Xaa Xaa Trp Glu Asp Val Gly Leu Trp Asp Pro Ser Leu Xaa 
    50                  55                  60                  


Lys Asn Gln Asp Tyr Arg Xaa Lys Pro Phe Cys Cys Ser Ala Cys Pro 
65                  70                  75                  80  


Phe Ser Ser Lys Phe Phe Ser Ala Tyr Lys Ser His Phe Arg Asn Val 
                85                  90                  95      


His Ser Glu Asp Phe Glu Asn Arg Ile Leu Leu Asn Cys Pro Tyr Cys 
            100                 105                 110         


Xaa Phe Asn Ala Asp Lys Lys Xaa Leu Glu Xaa His Ile Lys Ile Phe 
        115                 120                 125             


His Ala Pro Asn Ala Ser Ala Pro Ser Ser Ser Leu Ser Xaa Phe Lys 
    130                 135                 140                 


Asp Lys Asn Lys Asn Asp Gly Leu Lys Pro Lys Gln Ala Asp Ser Val 
145                 150                 155                 160 


Glu Gln Ala Val Tyr Tyr Cys Lys Lys Cys Xaa Tyr Arg Asp Pro Leu 
                165                 170                 175     


Tyr Glu Ile Val Arg Lys His Ile Tyr Arg Glu His Phe Gln His Val 
            180                 185                 190         


Ala Ala Pro Tyr Ile Ala Lys Ala Gly Glu Lys Ser Leu Asn Gly Ala 
        195                 200                 205             


Val Pro Leu Gly Ser Asn Ala Arg Glu Glu Ser Ser Ile His Cys Lys 
    210                 215                 220                 


Arg Cys Leu Phe Met Pro Lys Ser Tyr Glu Ala Leu Val Gln His Val 
225                 230                 235                 240 


Ile Glu Asp His Glu Arg Ile Gly Tyr Gln Val Xaa Ala Met Ile Gly 
                245                 250                 255     


His Xaa Asn Val Val Val Pro Arg Ser Lys Pro Leu Met Leu Ile Ala 
            260                 265                 270         


Pro Lys Pro Gln Asp Lys Lys Ser Met Gly Leu Pro Pro Arg Ile Gly 
        275                 280                 285             


Ser Leu Ala Ser Gly Asn Val Arg Ser Leu Pro Ser Gln Gln Met Val 
    290                 295                 300                 


Asn Arg Leu Ser Ile Pro Lys Pro Asn Leu Asn Ser Xaa Gly Val Asn 
305                 310                 315                 320 


Met Met Ser Ser Val His Leu Gln Gln Asn Asn Tyr Gly Val Lys Ser 
                325                 330                 335     


Val Gly Gln Gly Tyr Ser Val Gly Gln Ser Met Arg Leu Gly Leu Gly 
            340                 345                 350         


Gly Asn Ala Pro Val Ser Ile Pro Gln Gln Ser Gln Ser Val Lys Gln 
        355                 360                 365             


Leu Leu Pro Ser Gly Asn Gly Arg Ser Tyr Gly Leu Gly Ser Glu Gln 
    370                 375                 380                 


Arg Ser Gln Ala Pro Ala Arg Tyr Ser Leu Gln Ser Ala Asn Ala Ser 
385                 390                 395                 400 


Ser Leu Ser Ser Gly Gln Leu Lys Ser Pro Ser Leu Ser Gln Ser Gln 
                405                 410                 415     


Ala Ser Arg Val Leu Gly Gln Ser Ser Ser Lys Pro Ala Ala Ala Ala 
            420                 425                 430         


Xaa Gly Pro Pro Pro Gly Asn Xaa Ser Ser Xaa Gln Lys Trp Lys Ile 
        435                 440                 445             


Cys Xaa Ile Cys Asn Glu Leu Phe Pro Glu Asn Val Tyr Ser Val His 
    450                 455                 460                 


Phe Glu Lys Glu His Lys Ala Glu Lys Val Pro Ala Val Ala Asn Tyr 
465                 470                 475                 480 


Ile Met Lys Ile His Asn Phe Xaa Ser Lys Cys Leu Tyr Cys Asn Arg 
                485                 490                 495     


Tyr Leu Pro Xaa Asp Xaa Leu Leu Asn His Met Leu Ile His Gly Leu 
            500                 505                 510         


Ser Cys Pro Tyr Cys Arg Ser Xaa Phe Asn Asp Val Glu Lys Met Ala 
        515                 520                 525             


Ala His Met Arg Met Val His Ile Asp Glu Glu Met Gly Pro Lys Xaa 
    530                 535                 540                 


Asp Ser Xaa Leu Ser Phe Asp Leu Xaa Leu Gln Gln Gly Ser His Xaa 
545                 550                 555                 560 


Asn Ile His Leu Leu Val Xaa Xaa Tyr Asn Leu Arg Asp Ala Pro Ala 
                565                 570                 575     


Glu Ser Val Ala Tyr His Ala Gln Asn Asn Pro Pro Val Pro Pro Lys 
            580                 585                 590         


Pro Gln Pro Lys Val Gln Glu Lys Ala Asp Ile Pro Val Lys Ser Ser 
        595                 600                 605             


Pro Gln Ala Ala Val Pro Tyr Lys Lys Asp Val Gly Lys Xaa Leu Cys 
    610                 615                 620                 


Pro Leu Cys Phe Ser Ile Leu Lys Gly Pro Ile Ser Asp Ala Leu Ala 
625                 630                 635                 640 


His His Leu Arg Glu Arg His Gln Val Ile Gln Xaa Val His Pro Val 
                645                 650                 655     


Glu Lys Lys Leu Xaa Tyr Lys Cys Ile His Cys Leu Gly Val Tyr Xaa 
            660                 665                 670         


Ser Asn Met Xaa Ala Ser Xaa Ile Xaa Leu His Leu Val His Cys Arg 
        675                 680                 685             


Gly Val Gly Lys Xaa Gln Asn Gly Gln Asp Lys Xaa Asn Ala Pro Ser 
    690                 695                 700                 


Arg Leu Asn Gln Ser Pro Ser Leu Ala Pro Val Lys Arg Xaa Tyr Glu 
705                 710                 715                 720 


Gln Met Glu Phe Pro Leu Leu Lys Lys Arg Lys Leu Asp Asp Asp Ser 
                725                 730                 735     


Asp Ser Pro Ser Phe Phe Glu Glu Lys Pro Glu Glu Pro Val Val Leu 
            740                 745                 750         


Ala Leu Asp Pro Lys Gly His Glu Asp Asp Ser Tyr Glu Ala Arg Lys 
        755                 760                 765             


Ser Phe Leu Xaa Lys Tyr Phe Asn Lys Gln Pro Tyr Pro Xaa Arg Arg 
    770                 775                 780                 


Glu Ile Glu Lys Leu Ala Ala Ser Leu Trp Leu Trp Lys Ser Asp Ile 
785                 790                 795                 800 


Ala Ser His Phe Ser Asn Lys Arg Lys Lys Cys Val Arg Asp Cys Glu 
                805                 810                 815     


Lys Tyr Lys Pro Gly Val Leu Leu Gly Phe Asn Met Lys Glu Leu Asn 
            820                 825                 830         


Lys Val Lys His Glu Met Asp Phe Asp Ala Glu Trp Leu Phe Glu Asn 
        835                 840                 845             


His Asp Glu Lys Asp Ser Arg Val Asn Ala Ser Lys Xaa Ala Asp Lys 
    850                 855                 860                 


Lys Leu Asn Leu Gly Lys Glu Asp Asp Ser Ser Ser Asp Ser Phe Glu 
865                 870                 875                 880 


Asn Leu Glu Glu Glu Ser Asn Glu Ser Gly Ser Pro Phe Asp Pro Val 
                885                 890                 895     


Phe Glu Val Glu Pro Lys Ile Ser Asn Asp Asn Pro Glu Glu His Val 
            900                 905                 910         


Leu Lys Val Ile Pro Glu Asp Ala Ser Glu Ser Glu Glu Lys Leu Asp 
        915                 920                 925             


Gln Lys Glu Asp Gly Ser Lys Tyr Glu Xaa Ile His Leu Xaa Glu Glu 
    930                 935                 940                 


Pro Xaa Lys Leu Met His Asn Ala Ser Asp Ser Glu Val Asp Gln Asp 
945                 950                 955                 960 


Asp Val Val Glu Trp Lys Asp Gly Ala Ser Pro Ser Glu Ser Gly Pro 
                965                 970                 975     


Gly Ser Gln Gln Val Ser Asp Phe Glu Asp Asn Xaa Cys Glu Met Lys 
            980                 985                 990         


Pro Gly Xaa Trp Ser Asp Glu Ser  Ser Gln Ser Glu Asp  Ala Arg Ser 
        995                 1000                 1005             


Ser Lys  Pro Ala Ala Lys Lys  Lys Ala Xaa Met Gln  Gly Asp Arg 
    1010                 1015                 1020             


Glu Gln  Leu Lys Trp Lys Asn  Ser Ser Tyr Gly Lys  Val Glu Gly 
    1025                 1030                 1035             


Phe Trp  Ser Lys Asp Gln Ser  Gln Trp Lys Asn Ala  Ser Glu Asn 
    1040                 1045                 1050             


Asp Glu  Arg Leu Ser Asn Pro  Gln Ile Glu Trp Gln  Asn Ser Xaa 
    1055                 1060                 1065             


Ile Asp  Ser Glu Asp Gly Glu  Gln Phe Asp Asn Met  Xaa Asp Gly 
    1070                 1075                 1080             


Val Ala  Glu Pro Met His Gly  Ser Leu Ala Gly Val  Lys Leu Ser 
    1085                 1090                 1095             


Ser Gln  Gln Ala 
    1100         


<210> 1813
<211> 229
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<400> 1813
Met Phe Gln Ile Pro Val Glu Asn Leu Asp Asn Ile Arg Lys Asp Leu 
1               5                   10                  15      


Lys Gly Phe Asp Pro Gly Glu Lys Tyr Phe His Asn Xaa Ser Trp Gly 
            20                  25                  30          


Asp Val Ser Leu Trp Glu Pro Ser Gly Lys Lys Val Arg Tyr Arg Xaa 
        35                  40                  45              


Lys Pro Tyr Cys Cys Gly Leu Cys Lys Tyr Ser Xaa Lys Val Leu Xaa 
    50                  55                  60                  


Ser Phe Lys Asn His Leu His Arg Tyr His Glu Asp Glu Ile Asp Gln 
65                  70                  75                  80  


Glu Leu Val Ile Pro Cys Pro Asn Cys Val Phe Ala Ser Gln Pro Lys 
                85                  90                  95      


Val Val Gly Arg His Phe Arg Met Phe His Ala Pro Val Arg Lys Val 
            100                 105                 110         


Gln Asn Tyr Xaa Val Asn Ile Leu Gly Glu Xaa Lys Ser Ser Arg Ser 
        115                 120                 125             


Asp Val Ile Ser Phe Xaa Cys Leu Lys Cys Asn Phe Ser Asn Xaa Leu 
    130                 135                 140                 


Tyr Tyr Ser Met Lys Lys His Val Leu Val Ala His Phe His Tyr Leu 
145                 150                 155                 160 


Ile Asn Ser Tyr Phe Gly Leu Arg Xaa Glu Glu Met Gly Glu Gln Pro 
                165                 170                 175     


Lys Xaa Asn Asp Xaa Val Ser Ile Glu Lys Ile Pro Pro Pro Asp Lys 
            180                 185                 190         


Tyr Tyr Cys Lys Lys Cys Asn Ala Asn Ala Ser Ser Gln Asp Ala Leu 
        195                 200                 205             


Met Tyr His Ile Leu Xaa Ser Asp Ile His Arg Asp Leu Glu Asn Lys 
    210                 215                 220                 


Leu Arg Ser Val Ile 
225                 


<210> 1814
<211> 171
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 1814
Met Phe Gln Ile Pro Val Glu Asn Leu Asp Asn Ile Arg Lys Val Arg 
1               5                   10                  15      


Lys Lys Val Lys Gly Ile Leu Val Asp Ile Gly Leu Asp Ser Cys Lys 
            20                  25                  30          


Glu Leu Leu Lys Asp Leu Lys Gly Phe Asp Pro Gly Glu Lys Tyr Phe 
        35                  40                  45              


His Asn Xaa Ser Trp Gly Asp Val Ser Leu Trp Glu Pro Ser Gly Lys 
    50                  55                  60                  


Lys Val Arg Tyr Arg Xaa Lys Pro Tyr Cys Cys Gly Leu Cys Lys Tyr 
65                  70                  75                  80  


Ser Xaa Lys Val Leu Xaa Ser Phe Lys Asn His Leu His Arg Tyr His 
                85                  90                  95      


Glu Asp Glu Ile Asp Gln Glu Leu Val Ile Pro Cys Pro Asn Cys Val 
            100                 105                 110         


Phe Ala Ser Gln Pro Lys Val Val Gly Arg His Phe Arg Met Phe His 
        115                 120                 125             


Ala Pro Val Arg Lys Val Gln Asn Tyr Xaa Val Asn Ile Leu Gly Glu 
    130                 135                 140                 


Xaa Lys Ser Ser Arg Ser Asp Val Ile Ser Phe Xaa Cys Leu Lys Cys 
145                 150                 155                 160 


Asn Phe Ser Asn Xaa Leu Tyr Tyr Ser Met Lys 
                165                 170     


<210> 1815
<211> 1131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<400> 1815
Met Phe Gln Ile Pro Val Glu Asn Leu Asp Asn Ile Arg Lys Val Arg 
1               5                   10                  15      


Lys Lys Val Lys Gly Ile Leu Val Asp Ile Gly Leu Asp Ser Cys Lys 
            20                  25                  30          


Glu Leu Leu Lys Asp Leu Lys Gly Phe Asp Pro Gly Glu Lys Tyr Phe 
        35                  40                  45              


His Asn Xaa Ser Trp Gly Asp Val Ser Leu Trp Glu Pro Ser Gly Lys 
    50                  55                  60                  


Lys Val Arg Tyr Arg Xaa Lys Pro Tyr Cys Cys Gly Leu Cys Lys Tyr 
65                  70                  75                  80  


Ser Xaa Lys Val Leu Xaa Ser Phe Lys Asn His Leu His Arg Tyr His 
                85                  90                  95      


Glu Asp Glu Ile Asp Gln Glu Leu Val Ile Pro Cys Pro Asn Cys Val 
            100                 105                 110         


Phe Ala Ser Gln Pro Lys Val Val Gly Arg His Phe Arg Met Phe His 
        115                 120                 125             


Ala Pro Val Arg Lys Val Gln Asn Tyr Xaa Val Asn Ile Leu Gly Glu 
    130                 135                 140                 


Xaa Lys Ser Ser Arg Ser Asp Val Ile Ser Phe Xaa Cys Leu Lys Cys 
145                 150                 155                 160 


Asn Phe Ser Asn Xaa Leu Tyr Tyr Ser Met Lys Lys His Val Leu Val 
                165                 170                 175     


Ala His Phe His Tyr Leu Ile Asn Ser Tyr Phe Gly Leu Arg Xaa Glu 
            180                 185                 190         


Glu Met Gly Glu Gln Pro Lys Xaa Asn Asp Xaa Val Ser Ile Glu Lys 
        195                 200                 205             


Ile Pro Pro Pro Asp Lys Tyr Tyr Cys Lys Lys Cys Asn Ala Asn Ala 
    210                 215                 220                 


Ser Ser Gln Asp Ala Leu Met Tyr His Ile Leu Xaa Ser Asp Ile His 
225                 230                 235                 240 


Arg Asp Leu Glu Asn Lys Leu Arg Ser Val Ile Ser Glu His Ile Lys 
                245                 250                 255     


Arg Xaa Gly Leu Leu Lys Gln Xaa His Ile Ala Pro Lys Pro Ala Ala 
            260                 265                 270         


His Leu Ala Ala Pro Ala Asn Gly Ser Ala Pro Ser Ala Pro Ala Gln 
        275                 280                 285             


Pro Pro Cys Phe His Leu Ala Leu Pro Gln Asn Ser Pro Ser Pro Ala 
    290                 295                 300                 


Ala Gly Gln Pro Val Xaa Val Ala Gln Gly Ala Pro Gly Ser Leu Xaa 
305                 310                 315                 320 


His Ser Pro Pro Ala Ala Gly Gln Ser His Met Xaa Leu Val Ser Ser 
                325                 330                 335     


Pro Leu Pro Val Gly Gln Asn Ser Leu Xaa Leu Gln Pro Pro Ala Pro 
            340                 345                 350         


Gln Pro Val Phe Leu Ser His Gly Val Pro Leu His Gln Ser Val Asn 
        355                 360                 365             


Pro Pro Val Leu Pro Leu Ser Gln Pro Val Gly Pro Val Asn Lys Ser 
    370                 375                 380                 


Val Gly Xaa Ser Val Leu Pro Ile Asn Gln Xaa Val Arg Pro Gly Val 
385                 390                 395                 400 


Leu Pro Leu Xaa Gln Pro Val Gly Pro Ile Asn Arg Pro Val Gly Pro 
                405                 410                 415     


Gly Val Leu Pro Val Ser Pro Ser Val Xaa Pro Gly Val Leu Gln Ala 
            420                 425                 430         


Val Ser Pro Gly Val Leu Ser Val Ser Arg Ala Val Pro Ser Gly Val 
        435                 440                 445             


Leu Pro Ala Gly Gln Met Xaa Pro Ala Gly Gln Met Xaa Pro Ala Gly 
    450                 455                 460                 


Val Ile Pro Gly Gln Xaa Ala Xaa Ser Gly Val Leu Pro Xaa Gly Gln 
465                 470                 475                 480 


Met Val Gln Ser Gly Val Leu Pro Val Gly Gln Xaa Ala Pro Ser Arg 
                485                 490                 495     


Val Leu Pro Pro Gly Gln Xaa Ala Pro Leu Arg Val Ile Ser Ala Gly 
            500                 505                 510         


Gln Val Val Pro Ser Gly Leu Leu Ser Pro Asn Gln Xaa Val Ser Ser 
        515                 520                 525             


Ser Ala Val Val Pro Val Asn Gln Gly Val Asn Ser Gly Val Leu Gln 
    530                 535                 540                 


Leu Ser Gln Pro Val Val Ser Gly Val Leu Pro Val Gly Gln Pro Val 
545                 550                 555                 560 


Arg Pro Gly Val Leu Gln Leu Asn Gln Xaa Val Gly Xaa Asn Ile Leu 
                565                 570                 575     


Pro Val Asn Gln Pro Val Arg Pro Gly Ala Ser Gln Asn Xaa Xaa Phe 
            580                 585                 590         


Leu Xaa Ser Gly Ser Ile Leu Arg Gln Leu Ile Pro Xaa Gly Lys Gln 
        595                 600                 605             


Val Asn Gly Ile Pro Xaa Tyr Xaa Leu Ala Pro Val Ser Val Xaa Leu 
    610                 615                 620                 


Pro Val Pro Pro Gly Gly Leu Ala Xaa Val Ala Pro Pro Gln Met Pro 
625                 630                 635                 640 


Ile Gln Leu Leu Pro Ser Gly Ala Ala Ala Pro Met Ala Gly Ser Met 
                645                 650                 655     


Pro Gly Met Pro Ser Pro Pro Val Leu Val Asn Ala Ala Gln Ser Val 
            660                 665                 670         


Phe Val Gln Ala Ser Ser Ser Ala Ala Asp Xaa Asn Gln Val Leu Lys 
        675                 680                 685             


Gln Ala Lys Gln Trp Lys Xaa Cys Pro Val Cys Asn Glu Leu Phe Pro 
    690                 695                 700                 


Ser Asn Val Tyr Gln Val His Met Glu Val Ala His Lys His Ser Glu 
705                 710                 715                 720 


Ser Lys Ser Gly Glu Lys Leu Glu Pro Glu Lys Leu Ala Ala Cys Ala 
                725                 730                 735     


Pro Phe Leu Lys Trp Met Arg Glu Lys Xaa Val Arg Cys Leu Ser Cys 
            740                 745                 750         


Lys Cys Leu Val Ser Glu Glu Glu Leu Ile His His Leu Leu Met His 
        755                 760                 765             


Gly Leu Gly Cys Leu Phe Cys Pro Cys Xaa Phe His Asp Ile Lys Gly 
    770                 775                 780                 


Leu Ser Glu His Ser Arg Asn Arg His Leu Gly Lys Lys Lys Leu Pro 
785                 790                 795                 800 


Met Asp Tyr Ser Asn Arg Gly Phe Gln Leu Asp Val Asp Ala Asn Gly 
                805                 810                 815     


Asn Leu Leu Phe Pro His Leu Asp Phe Ile Xaa Ile Leu Pro Lys Glu 
            820                 825                 830         


Lys Leu Gly Glu Arg Glu Val Tyr Leu Ala Ile Leu Ala Gly Ile His 
        835                 840                 845             


Ser Lys Ser Leu Val Pro Val Tyr Val Lys Val Arg Pro Gln Ala Glu 
    850                 855                 860                 


Gly Xaa Pro Gly Ser Xaa Gly Lys Arg Val Ser Xaa Cys Pro Phe Cys 
865                 870                 875                 880 


Phe Gly Pro Phe Val Xaa Xaa Glu Ala Tyr Glu Leu His Leu Lys Glu 
                885                 890                 895     


Arg His His Ile Met Pro Xaa Val His Xaa Val Leu Lys Ser Pro Ala 
            900                 905                 910         


Phe Lys Cys Ile His Cys Cys Gly Val Tyr Xaa Gly Asn Met Xaa Leu 
        915                 920                 925             


Ala Ala Ile Ala Val His Leu Val Arg Cys Arg Ser Ala Pro Lys Asp 
    930                 935                 940                 


Ser Ser Ser Asp Leu Gln Ala Gln Pro Gly Phe Ile His Asn Ser Glu 
945                 950                 955                 960 


Leu Leu Leu Val Ser Gly Glu Val Met His Asp Ser Ser Phe Ser Val 
                965                 970                 975     


Lys Arg Lys Leu Pro Asp Gly His Leu Gly Ala Glu Asp Gln Arg His 
            980                 985                 990         


Gly Glu Glu Gln Pro Pro Ile Leu  Asn Ala Asp Ala Ala  Pro Gly Pro 
        995                 1000                 1005             


Glu Lys  Val Xaa Ser Val Val  Pro Phe Lys Arg Gln  Arg Asn Glu 
    1010                 1015                 1020             


Ser Arg  Xaa Glu Gly Pro Ile  Val Lys Asp Glu Ala  Leu Gln Ile 
    1025                 1030                 1035             


Leu Ala  Leu Asp Pro Lys Lys  Tyr Glu Gly Arg Ser  Tyr Glu Glu 
    1040                 1045                 1050             


Lys Lys  Gln Phe Leu Lys Asp  Tyr Phe His Lys Lys  Pro Tyr Pro 
    1055                 1060                 1065             


Ser Lys  Lys Glu Ile Glu Leu  Leu Ser Ser Leu Phe  Trp Val Trp 
    1070                 1075                 1080             


Lys Ile  Asp Val Ala Ser Phe  Phe Gly Lys Arg Arg  Tyr Ile Cys 
    1085                 1090                 1095             


Met Lys  Ala Ile Lys Asn His  Lys Pro Ser Val Leu  Leu Gly Phe 
    1100                 1105                 1110             


Asp Met  Ser Glu Leu Lys Asn  Val Lys His Arg Leu  Asn Phe Glu 
    1115                 1120                 1125             


Tyr Glu  Pro 
    1130     


<210> 1816
<211> 26
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 1816
Xaa Ile Gly Leu Asp Ser Cys Lys Glu Leu Leu Lys Pro Asp Arg Lys 
1               5                   10                  15      


Ser Gly Ala Leu Arg Cys Val Arg Ala Phe 
            20                  25      


<210> 1817
<211> 82
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<400> 1817
Xaa Leu Val Asp Ile Gly Leu Asp Ser Cys Lys Glu Leu Leu Lys Asp 
1               5                   10                  15      


Leu Lys Gly Phe Asp Pro Gly Glu Lys Tyr Phe His Asn Xaa Ser Trp 
            20                  25                  30          


Gly Asp Val Ser Leu Trp Glu Pro Ser Gly Lys Lys Val Leu Leu Ala 
        35                  40                  45              


Pro Ser Ser Val Ser Asp Ser Ala His Pro Arg Leu Asp Leu Ala Val 
    50                  55                  60                  


Pro Ser His Gln Leu Leu Trp Ser Lys Ser Cys Trp Pro Trp Glu Phe 
65                  70                  75                  80  


Gly Leu 
        


<210> 1818
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<400> 1818
Met Pro Pro Ser Ile Ser Ala Phe Gln Ala Ala Tyr Ile Gly Ile Glu 
1               5                   10                  15      


Val Leu Ile Ala Leu Val Ser Val Pro Gly Asn Val Leu Val Ile Trp 
            20                  25                  30          


Ala Val Lys Val Asn Gln Ala Leu Arg Asp Ala Xaa Phe Cys Phe Ile 
        35                  40                  45              


Val Ser Leu Ala Val Ala Asp Val Ala Val Gly Ala Leu Val Ile Pro 
    50                  55                  60                  


Leu Ala Ile Leu Ile Asn Ile Gly Pro Gln Xaa Tyr Phe His Xaa Cys 
65                  70                  75                  80  


Leu Met Val Ala Cys Pro Val Leu Ile Leu Xaa Gln Ser Ser Ile Leu 
                85                  90                  95      


Ala Leu Leu Ala Ile Ala Val Asp Arg Tyr Leu Arg Val Lys Ile Pro 
            100                 105                 110         


Leu Arg Arg Ile Ser Gln Cys Met Ala Ser Xaa Lys Ser 
        115                 120                 125 


<210> 1819
<211> 326
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<400> 1819
Met Pro Pro Ser Ile Ser Ala Phe Gln Ala Ala Tyr Ile Gly Ile Glu 
1               5                   10                  15      


Val Leu Ile Ala Leu Val Ser Val Pro Gly Asn Val Leu Val Ile Trp 
            20                  25                  30          


Ala Val Lys Val Asn Gln Ala Leu Arg Asp Ala Xaa Phe Cys Phe Ile 
        35                  40                  45              


Val Ser Leu Ala Val Ala Asp Val Ala Val Gly Ala Leu Val Ile Pro 
    50                  55                  60                  


Leu Ala Ile Leu Ile Asn Ile Gly Pro Gln Xaa Tyr Phe His Xaa Cys 
65                  70                  75                  80  


Leu Met Val Ala Cys Pro Val Leu Ile Leu Xaa Gln Ser Ser Ile Leu 
                85                  90                  95      


Ala Leu Leu Ala Ile Ala Val Asp Arg Tyr Leu Arg Val Lys Ile Pro 
            100                 105                 110         


Leu Arg Tyr Lys Met Val Val Xaa Pro Arg Arg Ala Ala Val Ala Ile 
        115                 120                 125             


Ala Gly Cys Trp Ile Leu Ser Phe Val Val Gly Leu Xaa Pro Met Phe 
    130                 135                 140                 


Gly Trp Asn Asn Leu Ser Ala Val Glu Arg Ala Trp Ala Ala Asn Gly 
145                 150                 155                 160 


Ser Met Gly Glu Pro Val Ile Lys Cys Glu Phe Glu Lys Val Ile Ser 
                165                 170                 175     


Met Glu Tyr Met Val Tyr Phe Asn Phe Phe Val Trp Val Leu Pro Pro 
            180                 185                 190         


Leu Leu Leu Met Val Leu Ile Tyr Leu Glu Val Phe Tyr Leu Ile Arg 
        195                 200                 205             


Lys Gln Leu Asn Lys Lys Val Ser Ala Ser Ser Gly Asp Pro Gln Lys 
    210                 215                 220                 


Tyr Tyr Gly Lys Glu Leu Lys Ile Ala Lys Ser Leu Ala Leu Ile Leu 
225                 230                 235                 240 


Phe Leu Phe Ala Leu Ser Trp Leu Pro Leu His Ile Leu Asn Cys Ile 
                245                 250                 255     


Xaa Leu Phe Cys Pro Ser Cys His Lys Pro Ser Ile Leu Xaa Tyr Ile 
            260                 265                 270         


Ala Ile Phe Leu Xaa His Gly Asn Ser Ala Met Asn Pro Ile Val Tyr 
        275                 280                 285             


Ala Phe Arg Ile Gln Lys Phe Arg Val Xaa Phe Leu Lys Ile Trp Asn 
    290                 295                 300                 


Asp His Phe Arg Cys Gln Pro Ala Pro Pro Ile Asp Glu Asp Leu Pro 
305                 310                 315                 320 


Glu Glu Arg Pro Asp Asp 
                325     


<210> 1820
<211> 210
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<400> 1820
Met Val Val Xaa Pro Arg Arg Ala Ala Val Ala Ile Ala Gly Cys Trp 
1               5                   10                  15      


Ile Leu Ser Phe Val Val Gly Leu Xaa Pro Met Phe Gly Trp Asn Asn 
            20                  25                  30          


Leu Ser Ala Val Glu Arg Ala Trp Ala Ala Asn Gly Ser Met Gly Glu 
        35                  40                  45              


Pro Val Ile Lys Cys Glu Phe Glu Lys Val Ile Ser Met Glu Tyr Met 
    50                  55                  60                  


Val Tyr Phe Asn Phe Phe Val Trp Val Leu Pro Pro Leu Leu Leu Met 
65                  70                  75                  80  


Val Leu Ile Tyr Leu Glu Val Phe Tyr Leu Ile Arg Lys Gln Leu Asn 
                85                  90                  95      


Lys Lys Val Ser Ala Ser Ser Gly Asp Pro Gln Lys Tyr Tyr Gly Lys 
            100                 105                 110         


Glu Leu Lys Ile Ala Lys Ser Leu Ala Leu Ile Leu Phe Leu Phe Ala 
        115                 120                 125             


Leu Ser Trp Leu Pro Leu His Ile Leu Asn Cys Ile Xaa Leu Phe Cys 
    130                 135                 140                 


Pro Ser Cys His Lys Pro Ser Ile Leu Xaa Tyr Ile Ala Ile Phe Leu 
145                 150                 155                 160 


Xaa His Gly Asn Ser Ala Met Asn Pro Ile Val Tyr Ala Phe Arg Ile 
                165                 170                 175     


Gln Lys Phe Arg Val Xaa Phe Leu Lys Ile Trp Asn Asp His Phe Arg 
            180                 185                 190         


Cys Gln Pro Ala Pro Pro Ile Asp Glu Asp Leu Pro Glu Glu Arg Pro 
        195                 200                 205             


Asp Asp 
    210 


<210> 1821
<211> 6
<212> PRT
<213> Homo sapiens

<400> 1821
Met Pro Ile Met Gly Ser 
1               5       


<210> 1822
<211> 29
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<400> 1822
Met Pro Ile Met Gly Ser Ser Val Tyr Ile Xaa Val Glu Leu Ala Ile 
1               5                   10                  15      


Ala Val Leu Ala Ile Leu Gly Asn Val Leu Val Cys Trp 
            20                  25                  


<210> 1823
<211> 64
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<400> 1823
Met Pro Ile Met Gly Ser Ser Val Tyr Ile Xaa Val Glu Leu Ala Ile 
1               5                   10                  15      


Ala Val Leu Ala Ile Leu Gly Asn Val Leu Val Cys Trp Ala Val Trp 
            20                  25                  30          


Leu Asn Ser Asn Leu Gln Asn Val Xaa Asn Tyr Phe Val Val Ser Leu 
        35                  40                  45              


Ala Ala Ala Asp Ile Ala Val Gly Val Leu Ala Ile Pro Phe Ala Ile 
    50                  55                  60                  


<210> 1824
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<400> 1824
Met Pro Ile Met Gly Ser Ser Val Tyr Ile Xaa Val Glu Leu Ala Ile 
1               5                   10                  15      


Ala Val Leu Ala Ile Leu Gly Asn Val Leu Val Cys Trp Ala Val Trp 
            20                  25                  30          


Leu Asn Ser Asn Leu Gln Asn Val Xaa Asn Tyr Phe Val Val Ser Leu 
        35                  40                  45              


Ala Ala Ala Asp Ile Ala Val Gly Val Leu Ala Ile Pro Phe Ala Ile 
    50                  55                  60                  


Xaa Ile Ser Xaa Gly Phe Cys Ala Ala Cys His Gly 
65                  70                  75      


<210> 1825
<211> 83
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<400> 1825
Met Pro Ile Met Gly Ser Ser Val Tyr Ile Xaa Val Glu Leu Ala Ile 
1               5                   10                  15      


Ala Val Leu Ala Ile Leu Gly Asn Val Leu Val Cys Trp Ala Val Trp 
            20                  25                  30          


Leu Asn Ser Asn Leu Gln Asn Val Xaa Asn Tyr Phe Val Val Ser Leu 
        35                  40                  45              


Ala Ala Ala Asp Ile Ala Val Gly Val Leu Ala Ile Pro Phe Ala Ile 
    50                  55                  60                  


Xaa Ile Ser Xaa Gly Phe Cys Ala Ala Cys His Gly Cys Leu Phe Ile 
65                  70                  75                  80  


Ala Cys Phe 
            


<210> 1826
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 1826
Met Pro Ile Met Gly Ser Ser Val Tyr Ile Xaa Val Glu Leu Ala Ile 
1               5                   10                  15      


Ala Val Leu Ala Ile Leu Gly Asn Val Leu Val Cys Trp Ala Val Trp 
            20                  25                  30          


Leu Asn Ser Asn Leu Gln Asn Val Xaa Asn Tyr Phe Val Val Ser Leu 
        35                  40                  45              


Ala Ala Ala Asp Ile Ala Val Gly Val Leu Ala Ile Pro Phe Ala Ile 
    50                  55                  60                  


Xaa Ile Ser Xaa Gly Phe Cys Ala Ala Cys His Gly Cys Leu Phe Ile 
65                  70                  75                  80  


Ala Cys Phe Val Leu Val Leu Xaa 
                85              


<210> 1827
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 1827
Met Pro Ile Met Gly Ser Ser Val Tyr Ile Xaa Val Glu Leu Ala Ile 
1               5                   10                  15      


Ala Val Leu Ala Ile Leu Gly Asn Val Leu Val Cys Trp Ala Val Trp 
            20                  25                  30          


Leu Asn Ser Asn Leu Gln Asn Val Xaa Asn Tyr Phe Val Val Ser Leu 
        35                  40                  45              


Ala Ala Ala Asp Ile Ala Val Gly Val Leu Ala Ile Pro Phe Ala Ile 
    50                  55                  60                  


Xaa Ile Ser Xaa Gly Phe Cys Ala Ala Cys His Gly Cys Leu Phe Ile 
65                  70                  75                  80  


Ala Cys Phe Val Leu Val Leu Xaa Gln Ser Ser Ile Phe Ser Leu Leu 
                85                  90                  95      


Ala Ile Ala Ile Asp Arg Tyr Ile Ala Ile Arg Ile 
            100                 105             


<210> 1828
<211> 365
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<400> 1828
Met Pro Ile Met Gly Ser Ser Val Tyr Ile Xaa Val Glu Leu Ala Ile 
1               5                   10                  15      


Ala Val Leu Ala Ile Leu Gly Asn Val Leu Val Cys Trp Ala Val Trp 
            20                  25                  30          


Leu Asn Ser Asn Leu Gln Asn Val Xaa Asn Tyr Phe Val Val Ser Leu 
        35                  40                  45              


Ala Ala Ala Asp Ile Ala Val Gly Val Leu Ala Ile Pro Phe Ala Ile 
    50                  55                  60                  


Xaa Ile Ser Xaa Gly Phe Cys Ala Ala Cys His Gly Cys Leu Phe Ile 
65                  70                  75                  80  


Ala Cys Phe Val Leu Val Leu Xaa Gln Ser Ser Ile Phe Ser Leu Leu 
                85                  90                  95      


Ala Ile Ala Ile Asp Arg Tyr Ile Ala Ile Arg Ile Pro Leu Arg Tyr 
            100                 105                 110         


Asn Gly Leu Val Xaa Gly Xaa Arg Ala Lys Gly Ile Ile Ala Ile Cys 
        115                 120                 125             


Trp Val Leu Ser Phe Ala Ile Gly Leu Xaa Pro Met Leu Gly Trp Asn 
    130                 135                 140                 


Asn Cys Gly Gln Pro Lys Glu Gly Lys Asn His Ser Gln Gly Cys Gly 
145                 150                 155                 160 


Glu Gly Gln Val Ala Cys Leu Phe Glu Asp Val Val Pro Met Asn Tyr 
                165                 170                 175     


Met Val Tyr Phe Asn Phe Phe Ala Cys Val Leu Val Pro Leu Leu Leu 
            180                 185                 190         


Met Leu Gly Val Tyr Leu Arg Ile Phe Leu Ala Ala Arg Arg Gln Leu 
        195                 200                 205             


Lys Gln Met Glu Ser Gln Pro Leu Pro Gly Glu Arg Ala Arg Ser Xaa 
    210                 215                 220                 


Leu Gln Lys Glu Val His Ala Ala Lys Ser Leu Ala Ile Ile Val Gly 
225                 230                 235                 240 


Leu Phe Ala Leu Cys Trp Leu Pro Leu His Ile Ile Asn Cys Phe Xaa 
                245                 250                 255     


Phe Phe Cys Pro Asp Cys Ser His Ala Pro Leu Trp Leu Met Tyr Leu 
            260                 265                 270         


Ala Ile Val Leu Ser His Xaa Asn Ser Val Val Asn Pro Phe Ile Tyr 
        275                 280                 285             


Ala Tyr Arg Ile Arg Glu Phe Arg Gln Xaa Phe Arg Lys Ile Ile Arg 
    290                 295                 300                 


Ser His Val Leu Arg Gln Gln Glu Pro Phe Lys Ala Ala Gly Xaa Ser 
305                 310                 315                 320 


Ala Arg Val Leu Ala Ala His Gly Ser Asp Gly Glu Gln Val Ser Leu 
                325                 330                 335     


Arg Leu Asn Gly His Pro Pro Gly Val Trp Ala Asn Gly Ser Ala Pro 
            340                 345                 350         


His Pro Glu Arg Arg Pro Asn Gly Tyr Ala Leu Gly Leu 
        355                 360                 365 


<210> 1829
<211> 412
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<400> 1829
Met Pro Ile Met Gly Ser Ser Val Tyr Ile Xaa Val Glu Leu Ala Ile 
1               5                   10                  15      


Ala Val Leu Ala Ile Leu Gly Asn Val Leu Val Cys Trp Ala Val Trp 
            20                  25                  30          


Leu Asn Ser Asn Leu Gln Asn Val Xaa Asn Tyr Phe Val Val Ser Leu 
        35                  40                  45              


Ala Ala Ala Asp Ile Ala Val Gly Val Leu Ala Ile Pro Phe Ala Ile 
    50                  55                  60                  


Xaa Ile Ser Xaa Gly Phe Cys Ala Ala Cys His Gly Cys Leu Phe Ile 
65                  70                  75                  80  


Ala Cys Phe Val Leu Val Leu Xaa Gln Ser Ser Ile Phe Ser Leu Leu 
                85                  90                  95      


Ala Ile Ala Ile Asp Arg Tyr Ile Ala Ile Arg Ile Pro Leu Arg Tyr 
            100                 105                 110         


Asn Gly Leu Val Xaa Gly Xaa Arg Ala Lys Gly Ile Ile Ala Ile Cys 
        115                 120                 125             


Trp Val Leu Ser Phe Ala Ile Gly Leu Xaa Pro Met Leu Gly Trp Asn 
    130                 135                 140                 


Asn Cys Gly Gln Pro Lys Glu Gly Lys Asn His Ser Gln Gly Cys Gly 
145                 150                 155                 160 


Glu Gly Gln Val Ala Cys Leu Phe Glu Asp Val Val Pro Met Asn Tyr 
                165                 170                 175     


Met Val Tyr Phe Asn Phe Phe Ala Cys Val Leu Val Pro Leu Leu Leu 
            180                 185                 190         


Met Leu Gly Val Tyr Leu Arg Ile Phe Leu Ala Ala Arg Arg Gln Leu 
        195                 200                 205             


Lys Gln Met Glu Ser Gln Pro Leu Pro Gly Glu Arg Ala Arg Ser Xaa 
    210                 215                 220                 


Leu Gln Lys Glu Val His Ala Ala Lys Ser Leu Ala Ile Ile Val Gly 
225                 230                 235                 240 


Leu Phe Ala Leu Cys Trp Leu Pro Leu His Ile Ile Asn Cys Phe Xaa 
                245                 250                 255     


Phe Phe Cys Pro Asp Cys Ser His Ala Pro Leu Trp Leu Met Tyr Leu 
            260                 265                 270         


Ala Ile Val Leu Ser His Xaa Asn Ser Val Val Asn Pro Phe Ile Tyr 
        275                 280                 285             


Ala Tyr Arg Ile Arg Glu Phe Arg Gln Xaa Phe Arg Lys Ile Ile Arg 
    290                 295                 300                 


Ser His Val Leu Arg Gln Gln Glu Pro Phe Lys Ala Ala Gly Xaa Ser 
305                 310                 315                 320 


Ala Arg Val Leu Ala Ala His Gly Ser Asp Gly Glu Gln Val Ser Leu 
                325                 330                 335     


Arg Leu Asn Gly His Pro Pro Gly Val Trp Ala Asn Gly Ser Ala Pro 
            340                 345                 350         


His Pro Glu Arg Arg Pro Asn Gly Tyr Ala Leu Gly Leu Val Ser Gly 
        355                 360                 365             


Gly Ser Ala Gln Glu Ser Gln Gly Asn Xaa Gly Leu Pro Asp Val Glu 
    370                 375                 380                 


Leu Leu Ser His Glu Leu Lys Gly Val Cys Pro Glu Pro Pro Gly Leu 
385                 390                 395                 400 


Asp Asp Pro Leu Ala Gln Asp Gly Ala Gly Val Ser 
                405                 410         


<210> 1830
<211> 332
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<400> 1830
Met Leu Leu Glu Xaa Gln Asp Ala Leu Tyr Val Ala Leu Glu Leu Val 
1               5                   10                  15      


Ile Ala Ala Leu Ser Val Ala Gly Asn Val Leu Val Cys Ala Ala Val 
            20                  25                  30          


Gly Xaa Ala Asn Xaa Leu Gln Xaa Pro Xaa Asn Tyr Phe Leu Val Ser 
        35                  40                  45              


Leu Ala Ala Ala Asp Val Ala Val Gly Leu Phe Ala Ile Pro Phe Ala 
    50                  55                  60                  


Ile Xaa Ile Ser Leu Gly Phe Cys Xaa Asp Phe Tyr Gly Cys Leu Phe 
65                  70                  75                  80  


Leu Ala Cys Phe Val Leu Val Leu Xaa Gln Ser Ser Ile Phe Ser Leu 
                85                  90                  95      


Leu Ala Val Ala Val Asp Arg Tyr Leu Ala Ile Cys Val Pro Leu Arg 
            100                 105                 110         


Tyr Lys Ser Leu Val Xaa Gly Xaa Arg Ala Arg Gly Val Ile Ala Val 
        115                 120                 125             


Leu Trp Val Leu Ala Phe Gly Ile Gly Leu Xaa Pro Phe Leu Gly Trp 
    130                 135                 140                 


Asn Ser Lys Asp Ser Ala Xaa Asn Asn Cys Xaa Glu Pro Trp Asp Gly 
145                 150                 155                 160 


Xaa Xaa Asn Glu Ser Cys Cys Leu Val Lys Cys Leu Phe Glu Asn Val 
                165                 170                 175     


Val Pro Met Ser Tyr Met Val Tyr Phe Asn Phe Phe Gly Cys Val Leu 
            180                 185                 190         


Pro Pro Leu Leu Ile Met Leu Val Ile Tyr Ile Lys Ile Phe Leu Val 
        195                 200                 205             


Ala Cys Arg Gln Leu Gln Arg Xaa Glu Leu Met Asp His Ser Arg Xaa 
    210                 215                 220                 


Xaa Leu Gln Arg Glu Ile His Ala Ala Lys Ser Leu Ala Met Ile Val 
225                 230                 235                 240 


Gly Ile Phe Ala Leu Cys Trp Leu Pro Val His Ala Val Asn Cys Val 
                245                 250                 255     


Xaa Leu Phe Gln Pro Ala Gln Gly Lys Asn Lys Pro Lys Trp Ala Met 
            260                 265                 270         


Asn Met Ala Ile Leu Leu Ser His Ala Asn Ser Val Val Asn Pro Ile 
        275                 280                 285             


Val Tyr Ala Tyr Arg Asn Arg Asp Phe Arg Tyr Xaa Phe His Lys Ile 
    290                 295                 300                 


Ile Ser Arg Tyr Leu Leu Cys Gln Ala Asp Val Lys Ser Gly Asn Gly 
305                 310                 315                 320 


Gln Ala Gly Val Gln Pro Ala Leu Gly Val Gly Leu 
                325                 330         


<210> 1831
<211> 318
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<400> 1831
Met Pro Asn Asn Ser Xaa Ala Leu Ser Leu Ala Asn Val Xaa Tyr Ile 
1               5                   10                  15      


Xaa Met Glu Ile Phe Ile Gly Leu Cys Ala Ile Val Gly Asn Val Leu 
            20                  25                  30          


Val Ile Cys Val Val Lys Leu Asn Pro Ser Leu Gln Xaa Xaa Xaa Phe 
        35                  40                  45              


Tyr Phe Ile Val Ser Leu Ala Leu Ala Asp Ile Ala Val Gly Val Leu 
    50                  55                  60                  


Val Met Pro Leu Ala Ile Val Val Ser Leu Gly Ile Xaa Ile His Phe 
65                  70                  75                  80  


Tyr Ser Cys Leu Phe Met Xaa Cys Leu Leu Leu Ile Phe Xaa His Ala 
                85                  90                  95      


Ser Ile Met Ser Leu Leu Ala Ile Ala Val Asp Arg Tyr Leu Arg Val 
            100                 105                 110         


Lys Leu Xaa Val Arg Tyr Lys Arg Val Xaa Xaa His Arg Arg Ile Trp 
        115                 120                 125             


Leu Ala Leu Gly Leu Cys Trp Leu Val Ser Phe Leu Val Gly Leu Xaa 
    130                 135                 140                 


Pro Met Phe Gly Trp Asn Met Lys Leu Xaa Ser Glu Tyr His Arg Asn 
145                 150                 155                 160 


Val Xaa Phe Leu Ser Cys Gln Phe Val Ser Val Met Arg Met Asp Tyr 
                165                 170                 175     


Met Val Tyr Phe Ser Phe Leu Xaa Trp Ile Phe Ile Pro Leu Val Val 
            180                 185                 190         


Met Cys Ala Ile Tyr Leu Asp Ile Phe Tyr Ile Ile Arg Asn Lys Leu 
        195                 200                 205             


Ser Leu Asn Leu Ser Asn Ser Lys Glu Xaa Gly Ala Phe Tyr Gly Arg 
    210                 215                 220                 


Glu Phe Lys Xaa Ala Lys Ser Leu Phe Leu Val Leu Phe Leu Phe Ala 
225                 230                 235                 240 


Leu Ser Trp Leu Pro Leu Ser Ile Ile Asn Cys Ile Ile Tyr Phe Asn 
                245                 250                 255     


Gly Glu Val Pro Gln Leu Val Leu Tyr Met Gly Ile Leu Leu Ser His 
            260                 265                 270         


Ala Asn Ser Met Met Asn Pro Ile Val Tyr Ala Tyr Lys Ile Lys Lys 
        275                 280                 285             


Phe Lys Glu Xaa Tyr Leu Leu Ile Leu Lys Ala Cys Val Val Cys His 
    290                 295                 300                 


Pro Ser Asp Ser Leu Asp Xaa Ser Ile Glu Lys Asn Ser Glu 
305                 310                 315             


<210> 1832
<211> 123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<400> 1832
Met Pro Asn Asn Ser Xaa Ala Leu Ser Leu Ala Asn Val Xaa Tyr Ile 
1               5                   10                  15      


Xaa Met Glu Ile Phe Ile Gly Leu Cys Ala Ile Val Gly Asn Val Leu 
            20                  25                  30          


Val Ile Cys Val Val Lys Leu Asn Pro Ser Leu Gln Xaa Xaa Xaa Phe 
        35                  40                  45              


Tyr Phe Ile Val Ser Leu Ala Leu Ala Asp Ile Ala Val Gly Val Leu 
    50                  55                  60                  


Val Met Pro Leu Ala Ile Val Val Ser Leu Gly Ile Xaa Ile His Phe 
65                  70                  75                  80  


Tyr Ser Cys Leu Phe Met Xaa Cys Leu Leu Leu Ile Phe Xaa His Ala 
                85                  90                  95      


Ser Ile Met Ser Leu Leu Ala Ile Ala Val Asp Arg Tyr Leu Arg Val 
            100                 105                 110         


Lys Leu Xaa Val Ser Ser Ile Ser Pro Xaa Leu 
        115                 120             


<210> 1833
<211> 324
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<400> 1833
Met Val Phe Leu Ser Gly Asn Ala Ser Asp Ser Ser Asn Cys Xaa Gln 
1               5                   10                  15      


Pro Pro Ala Pro Val Asn Ile Ser Lys Ala Ile Leu Leu Gly Val Ile 
            20                  25                  30          


Leu Gly Gly Leu Ile Leu Phe Gly Val Leu Gly Asn Ile Leu Val Ile 
        35                  40                  45              


Leu Ser Val Ala Cys His Arg His Leu His Ser Val Xaa His Tyr Tyr 
    50                  55                  60                  


Ile Val Asn Leu Ala Val Ala Asp Leu Leu Leu Xaa Ser Xaa Val Leu 
65                  70                  75                  80  


Pro Phe Ser Ala Ile Phe Glu Val Leu Gly Tyr Trp Ala Phe Gly Arg 
                85                  90                  95      


Val Phe Cys Asn Ile Trp Ala Ala Val Asp Val Leu Cys Cys Xaa Ala 
            100                 105                 110         


Ser Ile Met Gly Leu Cys Ile Ile Ser Ile Asp Arg Tyr Ile Gly Val 
        115                 120                 125             


Ser Tyr Pro Leu Arg Tyr Pro Xaa Ile Val Xaa Gln Arg Arg Gly Leu 
    130                 135                 140                 


Met Ala Leu Leu Cys Val Trp Ala Leu Ser Leu Val Ile Ser Ile Gly 
145                 150                 155                 160 


Pro Leu Phe Gly Trp Arg Gln Pro Ala Pro Glu Asp Glu Xaa Ile Cys 
                165                 170                 175     


Gln Ile Asn Glu Glu Pro Gly Tyr Val Leu Phe Ser Ala Leu Gly Ser 
            180                 185                 190         


Phe Tyr Leu Pro Leu Ala Ile Ile Leu Val Met Tyr Cys Arg Val Tyr 
        195                 200                 205             


Val Val Ala Lys Arg Glu Ser Arg Gly Leu Lys Ser Gly Leu Lys Xaa 
    210                 215                 220                 


Asp Lys Ser Asp Ser Glu Gln Val Xaa Leu Arg Ile His Arg Lys Asn 
225                 230                 235                 240 


Ala Pro Ala Gly Gly Ser Gly Met Ala Ser Ala Lys Xaa Lys Xaa His 
                245                 250                 255     


Phe Ser Val Arg Leu Leu Lys Phe Ser Arg Glu Lys Lys Ala Ala Lys 
            260                 265                 270         


Xaa Leu Gly Ile Val Val Gly Cys Phe Val Leu Cys Trp Leu Pro Phe 
        275                 280                 285             


Phe Leu Val Met Pro Ile Gly Xaa Tyr Ile Leu Lys Tyr Asp Val Leu 
    290                 295                 300                 


Phe Trp Arg Lys Gly Leu Ser Val Cys Xaa Arg Leu Arg Glu Arg Lys 
305                 310                 315                 320 


Glu Ile Lys Asn 
                


<210> 1834
<211> 342
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<400> 1834
Met Val Phe Leu Ser Gly Asn Ala Ser Asp Ser Ser Asn Cys Xaa Gln 
1               5                   10                  15      


Pro Pro Ala Pro Val Asn Ile Ser Lys Ala Ile Leu Leu Gly Val Ile 
            20                  25                  30          


Leu Gly Gly Leu Ile Leu Phe Gly Val Leu Gly Asn Ile Leu Val Ile 
        35                  40                  45              


Leu Ser Val Ala Cys His Arg His Leu His Ser Val Xaa His Tyr Tyr 
    50                  55                  60                  


Ile Val Asn Leu Ala Val Ala Asp Leu Leu Leu Xaa Ser Xaa Val Leu 
65                  70                  75                  80  


Pro Phe Ser Ala Ile Phe Glu Val Leu Gly Tyr Trp Ala Phe Gly Arg 
                85                  90                  95      


Val Phe Cys Asn Ile Trp Ala Ala Val Asp Val Leu Cys Cys Xaa Ala 
            100                 105                 110         


Ser Ile Met Gly Leu Cys Ile Ile Ser Ile Asp Arg Tyr Ile Gly Val 
        115                 120                 125             


Ser Tyr Pro Leu Arg Tyr Pro Xaa Ile Val Xaa Gln Arg Arg Gly Leu 
    130                 135                 140                 


Met Ala Leu Leu Cys Val Trp Ala Leu Ser Leu Val Ile Ser Ile Gly 
145                 150                 155                 160 


Pro Leu Phe Gly Trp Arg Gln Pro Ala Pro Glu Asp Glu Xaa Ile Cys 
                165                 170                 175     


Gln Ile Asn Glu Glu Pro Gly Tyr Val Leu Phe Ser Ala Leu Gly Ser 
            180                 185                 190         


Phe Tyr Leu Pro Leu Ala Ile Ile Leu Val Met Tyr Cys Arg Val Tyr 
        195                 200                 205             


Val Val Ala Lys Arg Glu Ser Arg Gly Leu Lys Ser Gly Leu Lys Xaa 
    210                 215                 220                 


Asp Lys Ser Asp Ser Glu Gln Val Xaa Leu Arg Ile His Arg Lys Asn 
225                 230                 235                 240 


Ala Pro Ala Gly Gly Ser Gly Met Ala Ser Ala Lys Xaa Lys Xaa His 
                245                 250                 255     


Phe Ser Val Arg Leu Leu Lys Phe Ser Arg Glu Lys Lys Ala Ala Lys 
            260                 265                 270         


Xaa Leu Gly Ile Val Val Gly Cys Phe Val Leu Cys Trp Leu Pro Phe 
        275                 280                 285             


Phe Leu Val Met Pro Ile Asp Glu Glu Xaa Glu Ala Gln Glu Gly Lys 
    290                 295                 300                 


Asn Asp Ser Pro Ser Phe Lys Gln Pro Val His His Ala Ala Val Leu 
305                 310                 315                 320 


Gly Leu Glu Val Met Glu Lys Glu Asn Leu Glu Gly Val Ser Arg Lys 
                325                 330                 335     


Asp Xaa Cys Gly Val Trp 
            340         


<210> 1835
<211> 427
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(421)
<223> Selenocysteine

<400> 1835
Met Val Phe Leu Ser Gly Asn Ala Ser Asp Ser Ser Asn Cys Xaa Gln 
1               5                   10                  15      


Pro Pro Ala Pro Val Asn Ile Ser Lys Ala Ile Leu Leu Gly Val Ile 
            20                  25                  30          


Leu Gly Gly Leu Ile Leu Phe Gly Val Leu Gly Asn Ile Leu Val Ile 
        35                  40                  45              


Leu Ser Val Ala Cys His Arg His Leu His Ser Val Xaa His Tyr Tyr 
    50                  55                  60                  


Ile Val Asn Leu Ala Val Ala Asp Leu Leu Leu Xaa Ser Xaa Val Leu 
65                  70                  75                  80  


Pro Phe Ser Ala Ile Phe Glu Val Leu Gly Tyr Trp Ala Phe Gly Arg 
                85                  90                  95      


Val Phe Cys Asn Ile Trp Ala Ala Val Asp Val Leu Cys Cys Xaa Ala 
            100                 105                 110         


Ser Ile Met Gly Leu Cys Ile Ile Ser Ile Asp Arg Tyr Ile Gly Val 
        115                 120                 125             


Ser Tyr Pro Leu Arg Tyr Pro Xaa Ile Val Xaa Gln Arg Arg Gly Leu 
    130                 135                 140                 


Met Ala Leu Leu Cys Val Trp Ala Leu Ser Leu Val Ile Ser Ile Gly 
145                 150                 155                 160 


Pro Leu Phe Gly Trp Arg Gln Pro Ala Pro Glu Asp Glu Xaa Ile Cys 
                165                 170                 175     


Gln Ile Asn Glu Glu Pro Gly Tyr Val Leu Phe Ser Ala Leu Gly Ser 
            180                 185                 190         


Phe Tyr Leu Pro Leu Ala Ile Ile Leu Val Met Tyr Cys Arg Val Tyr 
        195                 200                 205             


Val Val Ala Lys Arg Glu Ser Arg Gly Leu Lys Ser Gly Leu Lys Xaa 
    210                 215                 220                 


Asp Lys Ser Asp Ser Glu Gln Val Xaa Leu Arg Ile His Arg Lys Asn 
225                 230                 235                 240 


Ala Pro Ala Gly Gly Ser Gly Met Ala Ser Ala Lys Xaa Lys Xaa His 
                245                 250                 255     


Phe Ser Val Arg Leu Leu Lys Phe Ser Arg Glu Lys Lys Ala Ala Lys 
            260                 265                 270         


Xaa Leu Gly Ile Val Val Gly Cys Phe Val Leu Cys Trp Leu Pro Phe 
        275                 280                 285             


Phe Leu Val Met Pro Ile Gly Ser Phe Phe Pro Asp Phe Lys Pro Ser 
    290                 295                 300                 


Glu Xaa Val Phe Lys Ile Val Phe Trp Leu Gly Tyr Leu Asn Ser Cys 
305                 310                 315                 320 


Ile Asn Pro Ile Ile Tyr Pro Cys Ser Ser Gln Glu Phe Lys Lys Ala 
                325                 330                 335     


Phe Gln Asn Val Leu Arg Ile Gln Cys Leu Cys Arg Lys Gln Ser Ser 
            340                 345                 350         


Lys His Ala Leu Gly Tyr Xaa Leu His Pro Pro Ser Gln Ala Val Glu 
        355                 360                 365             


Gly Gln His Lys Asp Met Val Arg Ile Pro Val Gly Ser Arg Glu Xaa 
    370                 375                 380                 


Phe Tyr Arg Ile Ser Lys Xaa Asp Gly Val Cys Glu Trp Lys Phe Phe 
385                 390                 395                 400 


Ser Ser Met Pro Arg Gly Ser Ala Arg Ile Xaa Val Ser Lys Asp Gln 
                405                 410                 415     


Ser Ser Cys Xaa Xaa Ala Arg Ser Ser Gly Phe 
            420                 425         


<210> 1836
<211> 429
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<400> 1836
Met Val Phe Leu Ser Gly Asn Ala Ser Asp Ser Ser Asn Cys Xaa Gln 
1               5                   10                  15      


Pro Pro Ala Pro Val Asn Ile Ser Lys Ala Ile Leu Leu Gly Val Ile 
            20                  25                  30          


Leu Gly Gly Leu Ile Leu Phe Gly Val Leu Gly Asn Ile Leu Val Ile 
        35                  40                  45              


Leu Ser Val Ala Cys His Arg His Leu His Ser Val Xaa His Tyr Tyr 
    50                  55                  60                  


Ile Val Asn Leu Ala Val Ala Asp Leu Leu Leu Xaa Ser Xaa Val Leu 
65                  70                  75                  80  


Pro Phe Ser Ala Ile Phe Glu Val Leu Gly Tyr Trp Ala Phe Gly Arg 
                85                  90                  95      


Val Phe Cys Asn Ile Trp Ala Ala Val Asp Val Leu Cys Cys Xaa Ala 
            100                 105                 110         


Ser Ile Met Gly Leu Cys Ile Ile Ser Ile Asp Arg Tyr Ile Gly Val 
        115                 120                 125             


Ser Tyr Pro Leu Arg Tyr Pro Xaa Ile Val Xaa Gln Arg Arg Gly Leu 
    130                 135                 140                 


Met Ala Leu Leu Cys Val Trp Ala Leu Ser Leu Val Ile Ser Ile Gly 
145                 150                 155                 160 


Pro Leu Phe Gly Trp Arg Gln Pro Ala Pro Glu Asp Glu Xaa Ile Cys 
                165                 170                 175     


Gln Ile Asn Glu Glu Pro Gly Tyr Val Leu Phe Ser Ala Leu Gly Ser 
            180                 185                 190         


Phe Tyr Leu Pro Leu Ala Ile Ile Leu Val Met Tyr Cys Arg Val Tyr 
        195                 200                 205             


Val Val Ala Lys Arg Glu Ser Arg Gly Leu Lys Ser Gly Leu Lys Xaa 
    210                 215                 220                 


Asp Lys Ser Asp Ser Glu Gln Val Xaa Leu Arg Ile His Arg Lys Asn 
225                 230                 235                 240 


Ala Pro Ala Gly Gly Ser Gly Met Ala Ser Ala Lys Xaa Lys Xaa His 
                245                 250                 255     


Phe Ser Val Arg Leu Leu Lys Phe Ser Arg Glu Lys Lys Ala Ala Lys 
            260                 265                 270         


Xaa Leu Gly Ile Val Val Gly Cys Phe Val Leu Cys Trp Leu Pro Phe 
        275                 280                 285             


Phe Leu Val Met Pro Ile Gly Ser Phe Phe Pro Asp Phe Lys Pro Ser 
    290                 295                 300                 


Glu Xaa Val Phe Lys Ile Val Phe Trp Leu Gly Tyr Leu Asn Ser Cys 
305                 310                 315                 320 


Ile Asn Pro Ile Ile Tyr Pro Cys Ser Ser Gln Glu Phe Lys Lys Ala 
                325                 330                 335     


Phe Gln Asn Val Leu Arg Ile Gln Cys Leu Cys Arg Lys Gln Ser Ser 
            340                 345                 350         


Lys His Ala Leu Gly Tyr Xaa Leu His Pro Pro Ser Gln Ala Val Glu 
        355                 360                 365             


Gly Gln His Lys Asp Met Val Arg Ile Pro Val Gly Ser Arg Glu Xaa 
    370                 375                 380                 


Phe Tyr Arg Ile Ser Lys Xaa Asp Gly Val Cys Glu Trp Lys Phe Phe 
385                 390                 395                 400 


Ser Ser Met Pro Arg Gly Ser Ala Arg Ile Xaa Val Ser Lys Asp Gln 
                405                 410                 415     


Ser Ser Cys Xaa Xaa Ala Arg Gly His Xaa Pro Met Xaa 
            420                 425                 


<210> 1837
<211> 455
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<400> 1837
Met Val Phe Leu Ser Gly Asn Ala Ser Asp Ser Ser Asn Cys Xaa Gln 
1               5                   10                  15      


Pro Pro Ala Pro Val Asn Ile Ser Lys Ala Ile Leu Leu Gly Val Ile 
            20                  25                  30          


Leu Gly Gly Leu Ile Leu Phe Gly Val Leu Gly Asn Ile Leu Val Ile 
        35                  40                  45              


Leu Ser Val Ala Cys His Arg His Leu His Ser Val Xaa His Tyr Tyr 
    50                  55                  60                  


Ile Val Asn Leu Ala Val Ala Asp Leu Leu Leu Xaa Ser Xaa Val Leu 
65                  70                  75                  80  


Pro Phe Ser Ala Ile Phe Glu Val Leu Gly Tyr Trp Ala Phe Gly Arg 
                85                  90                  95      


Val Phe Cys Asn Ile Trp Ala Ala Val Asp Val Leu Cys Cys Xaa Ala 
            100                 105                 110         


Ser Ile Met Gly Leu Cys Ile Ile Ser Ile Asp Arg Tyr Ile Gly Val 
        115                 120                 125             


Ser Tyr Pro Leu Arg Tyr Pro Xaa Ile Val Xaa Gln Arg Arg Gly Leu 
    130                 135                 140                 


Met Ala Leu Leu Cys Val Trp Ala Leu Ser Leu Val Ile Ser Ile Gly 
145                 150                 155                 160 


Pro Leu Phe Gly Trp Arg Gln Pro Ala Pro Glu Asp Glu Xaa Ile Cys 
                165                 170                 175     


Gln Ile Asn Glu Glu Pro Gly Tyr Val Leu Phe Ser Ala Leu Gly Ser 
            180                 185                 190         


Phe Tyr Leu Pro Leu Ala Ile Ile Leu Val Met Tyr Cys Arg Val Tyr 
        195                 200                 205             


Val Val Ala Lys Arg Glu Ser Arg Gly Leu Lys Ser Gly Leu Lys Xaa 
    210                 215                 220                 


Asp Lys Ser Asp Ser Glu Gln Val Xaa Leu Arg Ile His Arg Lys Asn 
225                 230                 235                 240 


Ala Pro Ala Gly Gly Ser Gly Met Ala Ser Ala Lys Xaa Lys Xaa His 
                245                 250                 255     


Phe Ser Val Arg Leu Leu Lys Phe Ser Arg Glu Lys Lys Ala Ala Lys 
            260                 265                 270         


Xaa Leu Gly Ile Val Val Gly Cys Phe Val Leu Cys Trp Leu Pro Phe 
        275                 280                 285             


Phe Leu Val Met Pro Ile Gly Ser Phe Phe Pro Asp Phe Lys Pro Ser 
    290                 295                 300                 


Glu Xaa Val Phe Lys Ile Val Phe Trp Leu Gly Tyr Leu Asn Ser Cys 
305                 310                 315                 320 


Ile Asn Pro Ile Ile Tyr Pro Cys Ser Ser Gln Glu Phe Lys Lys Ala 
                325                 330                 335     


Phe Gln Asn Val Leu Arg Ile Gln Cys Leu Cys Arg Lys Gln Ser Ser 
            340                 345                 350         


Lys His Ala Leu Gly Tyr Xaa Leu His Pro Pro Ser Gln Ala Val Glu 
        355                 360                 365             


Gly Gln His Lys Asp Met Val Arg Ile Pro Val Gly Ser Arg Glu Xaa 
    370                 375                 380                 


Phe Tyr Arg Ile Ser Lys Xaa Asp Gly Val Cys Glu Trp Lys Phe Phe 
385                 390                 395                 400 


Ser Ser Met Pro Arg Gly Ser Ala Arg Ile Xaa Val Ser Lys Asp Gln 
                405                 410                 415     


Ser Ser Cys Xaa Xaa Ala Arg Arg Gly Met Asp Cys Arg Tyr Phe Xaa 
            420                 425                 430         


Lys Asn Cys Arg Glu His Ile Lys His Val Asn Phe Met Met Pro Pro 
        435                 440                 445             


Trp Arg Lys Gly Ser Glu Cys 
    450                 455 


<210> 1838
<211> 466
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<400> 1838
Met Val Phe Leu Ser Gly Asn Ala Ser Asp Ser Ser Asn Cys Xaa Gln 
1               5                   10                  15      


Pro Pro Ala Pro Val Asn Ile Ser Lys Ala Ile Leu Leu Gly Val Ile 
            20                  25                  30          


Leu Gly Gly Leu Ile Leu Phe Gly Val Leu Gly Asn Ile Leu Val Ile 
        35                  40                  45              


Leu Ser Val Ala Cys His Arg His Leu His Ser Val Xaa His Tyr Tyr 
    50                  55                  60                  


Ile Val Asn Leu Ala Val Ala Asp Leu Leu Leu Xaa Ser Xaa Val Leu 
65                  70                  75                  80  


Pro Phe Ser Ala Ile Phe Glu Val Leu Gly Tyr Trp Ala Phe Gly Arg 
                85                  90                  95      


Val Phe Cys Asn Ile Trp Ala Ala Val Asp Val Leu Cys Cys Xaa Ala 
            100                 105                 110         


Ser Ile Met Gly Leu Cys Ile Ile Ser Ile Asp Arg Tyr Ile Gly Val 
        115                 120                 125             


Ser Tyr Pro Leu Arg Tyr Pro Xaa Ile Val Xaa Gln Arg Arg Gly Leu 
    130                 135                 140                 


Met Ala Leu Leu Cys Val Trp Ala Leu Ser Leu Val Ile Ser Ile Gly 
145                 150                 155                 160 


Pro Leu Phe Gly Trp Arg Gln Pro Ala Pro Glu Asp Glu Xaa Ile Cys 
                165                 170                 175     


Gln Ile Asn Glu Glu Pro Gly Tyr Val Leu Phe Ser Ala Leu Gly Ser 
            180                 185                 190         


Phe Tyr Leu Pro Leu Ala Ile Ile Leu Val Met Tyr Cys Arg Val Tyr 
        195                 200                 205             


Val Val Ala Lys Arg Glu Ser Arg Gly Leu Lys Ser Gly Leu Lys Xaa 
    210                 215                 220                 


Asp Lys Ser Asp Ser Glu Gln Val Xaa Leu Arg Ile His Arg Lys Asn 
225                 230                 235                 240 


Ala Pro Ala Gly Gly Ser Gly Met Ala Ser Ala Lys Xaa Lys Xaa His 
                245                 250                 255     


Phe Ser Val Arg Leu Leu Lys Phe Ser Arg Glu Lys Lys Ala Ala Lys 
            260                 265                 270         


Xaa Leu Gly Ile Val Val Gly Cys Phe Val Leu Cys Trp Leu Pro Phe 
        275                 280                 285             


Phe Leu Val Met Pro Ile Gly Ser Phe Phe Pro Asp Phe Lys Pro Ser 
    290                 295                 300                 


Glu Xaa Val Phe Lys Ile Val Phe Trp Leu Gly Tyr Leu Asn Ser Cys 
305                 310                 315                 320 


Ile Asn Pro Ile Ile Tyr Pro Cys Ser Ser Gln Glu Phe Lys Lys Ala 
                325                 330                 335     


Phe Gln Asn Val Leu Arg Ile Gln Cys Leu Cys Arg Lys Gln Ser Ser 
            340                 345                 350         


Lys His Ala Leu Gly Tyr Xaa Leu His Pro Pro Ser Gln Ala Val Glu 
        355                 360                 365             


Gly Gln His Lys Asp Met Val Arg Ile Pro Val Gly Ser Arg Glu Xaa 
    370                 375                 380                 


Phe Tyr Arg Ile Ser Lys Xaa Asp Gly Val Cys Glu Trp Lys Phe Phe 
385                 390                 395                 400 


Ser Ser Met Pro Arg Gly Ser Ala Arg Ile Xaa Val Ser Lys Asp Gln 
                405                 410                 415     


Ser Ser Cys Xaa Xaa Ala Arg Val Arg Ser Lys Ser Phe Leu Gln Val 
            420                 425                 430         


Cys Cys Cys Val Gly Pro Ser Xaa Pro Ser Leu Asp Lys Asn His Gln 
        435                 440                 445             


Val Pro Xaa Ile Lys Val His Xaa Ile Ser Leu Ser Glu Asn Gly Glu 
    450                 455                 460                 


Glu Val 
465     


<210> 1839
<211> 475
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<400> 1839
Met Val Phe Leu Ser Gly Asn Ala Ser Asp Ser Ser Asn Cys Xaa Gln 
1               5                   10                  15      


Pro Pro Ala Pro Val Asn Ile Ser Lys Ala Ile Leu Leu Gly Val Ile 
            20                  25                  30          


Leu Gly Gly Leu Ile Leu Phe Gly Val Leu Gly Asn Ile Leu Val Ile 
        35                  40                  45              


Leu Ser Val Ala Cys His Arg His Leu His Ser Val Xaa His Tyr Tyr 
    50                  55                  60                  


Ile Val Asn Leu Ala Val Ala Asp Leu Leu Leu Xaa Ser Xaa Val Leu 
65                  70                  75                  80  


Pro Phe Ser Ala Ile Phe Glu Val Leu Gly Tyr Trp Ala Phe Gly Arg 
                85                  90                  95      


Val Phe Cys Asn Ile Trp Ala Ala Val Asp Val Leu Cys Cys Xaa Ala 
            100                 105                 110         


Ser Ile Met Gly Leu Cys Ile Ile Ser Ile Asp Arg Tyr Ile Gly Val 
        115                 120                 125             


Ser Tyr Pro Leu Arg Tyr Pro Xaa Ile Val Xaa Gln Arg Arg Gly Leu 
    130                 135                 140                 


Met Ala Leu Leu Cys Val Trp Ala Leu Ser Leu Val Ile Ser Ile Gly 
145                 150                 155                 160 


Pro Leu Phe Gly Trp Arg Gln Pro Ala Pro Glu Asp Glu Xaa Ile Cys 
                165                 170                 175     


Gln Ile Asn Glu Glu Pro Gly Tyr Val Leu Phe Ser Ala Leu Gly Ser 
            180                 185                 190         


Phe Tyr Leu Pro Leu Ala Ile Ile Leu Val Met Tyr Cys Arg Val Tyr 
        195                 200                 205             


Val Val Ala Lys Arg Glu Ser Arg Gly Leu Lys Ser Gly Leu Lys Xaa 
    210                 215                 220                 


Asp Lys Ser Asp Ser Glu Gln Val Xaa Leu Arg Ile His Arg Lys Asn 
225                 230                 235                 240 


Ala Pro Ala Gly Gly Ser Gly Met Ala Ser Ala Lys Xaa Lys Xaa His 
                245                 250                 255     


Phe Ser Val Arg Leu Leu Lys Phe Ser Arg Glu Lys Lys Ala Ala Lys 
            260                 265                 270         


Xaa Leu Gly Ile Val Val Gly Cys Phe Val Leu Cys Trp Leu Pro Phe 
        275                 280                 285             


Phe Leu Val Met Pro Ile Gly Ser Phe Phe Pro Asp Phe Lys Pro Ser 
    290                 295                 300                 


Glu Xaa Val Phe Lys Ile Val Phe Trp Leu Gly Tyr Leu Asn Ser Cys 
305                 310                 315                 320 


Ile Asn Pro Ile Ile Tyr Pro Cys Ser Ser Gln Glu Phe Lys Lys Ala 
                325                 330                 335     


Phe Gln Asn Val Leu Arg Ile Gln Cys Leu Cys Arg Lys Gln Ser Ser 
            340                 345                 350         


Lys His Ala Leu Gly Tyr Xaa Leu His Pro Pro Ser Gln Ala Val Glu 
        355                 360                 365             


Gly Gln His Lys Asp Met Val Arg Ile Pro Val Gly Ser Arg Glu Xaa 
    370                 375                 380                 


Phe Tyr Arg Ile Ser Lys Xaa Asp Gly Val Cys Glu Trp Lys Phe Phe 
385                 390                 395                 400 


Ser Ser Met Pro Arg Gly Ser Ala Arg Ile Xaa Val Ser Lys Asp Gln 
                405                 410                 415     


Ser Ser Cys Xaa Xaa Ala Arg Xaa Lys Ser Arg Ser Val Xaa Arg Leu 
            420                 425                 430         


Glu Cys Ser Gly Met Ile Leu Ala His Cys Asn Leu Arg Leu Pro Gly 
        435                 440                 445             


Ser Arg Asp Ser Pro Ala Ser Ala Ser Gln Ala Ala Gly Xaa Xaa Gly 
    450                 455                 460                 


Met Cys His Gln Ala Asp Ala Xaa Arg Pro Ser 
465                 470                 475 


<210> 1840
<211> 520
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<400> 1840
Met Asn Pro Asp Leu Asp Xaa Gly His Asn Xaa Ser Ala Pro Ala His 
1               5                   10                  15      


Trp Gly Glu Leu Lys Asn Ala Asn Phe Xaa Gly Pro Asn Gln Xaa Ser 
            20                  25                  30          


Ser Asn Ser Xaa Leu Pro Gln Leu Asp Ile Xaa Arg Ala Ile Ser Val 
        35                  40                  45              


Gly Leu Val Leu Gly Ala Phe Ile Leu Phe Ala Ile Val Gly Asn Ile 
    50                  55                  60                  


Leu Val Ile Leu Ser Val Ala Cys Asn Arg His Leu Arg Xaa Pro Xaa 
65                  70                  75                  80  


Asn Tyr Phe Ile Val Asn Leu Ala Met Ala Asp Leu Leu Leu Ser Phe 
                85                  90                  95      


Xaa Val Leu Pro Phe Ser Ala Ala Leu Glu Val Leu Gly Tyr Trp Val 
            100                 105                 110         


Leu Gly Arg Ile Phe Cys Asp Ile Trp Ala Ala Val Asp Val Leu Cys 
        115                 120                 125             


Cys Xaa Ala Ser Ile Leu Ser Leu Cys Ala Ile Ser Ile Asp Arg Tyr 
    130                 135                 140                 


Ile Gly Val Arg Tyr Ser Leu Gln Tyr Pro Xaa Leu Val Xaa Arg Arg 
145                 150                 155                 160 


Lys Ala Ile Leu Ala Leu Leu Ser Val Trp Val Leu Ser Xaa Val Ile 
                165                 170                 175     


Ser Ile Gly Pro Leu Leu Gly Trp Lys Glu Pro Ala Pro Asn Asp Asp 
            180                 185                 190         


Lys Glu Cys Gly Val Xaa Glu Glu Pro Phe Tyr Ala Leu Phe Ser Ser 
        195                 200                 205             


Leu Gly Ser Phe Tyr Ile Pro Leu Ala Val Ile Leu Val Met Tyr Cys 
    210                 215                 220                 


Arg Val Tyr Ile Val Ala Lys Arg Xaa Xaa Lys Asn Leu Glu Ala Gly 
225                 230                 235                 240 


Val Met Lys Glu Met Ser Asn Ser Lys Glu Leu Xaa Leu Arg Ile His 
                245                 250                 255     


Ser Lys Asn Phe His Glu Asp Xaa Leu Ser Ser Xaa Lys Ala Lys Gly 
            260                 265                 270         


His Asn Pro Arg Ser Ser Ile Ala Val Lys Leu Phe Lys Phe Ser Arg 
        275                 280                 285             


Glu Lys Lys Ala Ala Lys Xaa Leu Gly Ile Val Val Gly Met Phe Ile 
    290                 295                 300                 


Leu Cys Trp Leu Pro Phe Phe Ile Ala Leu Pro Leu Gly Ser Leu Phe 
305                 310                 315                 320 


Ser Xaa Leu Lys Pro Pro Asp Ala Val Phe Lys Val Val Phe Trp Leu 
                325                 330                 335     


Gly Tyr Phe Asn Ser Cys Leu Asn Pro Ile Ile Tyr Pro Cys Ser Ser 
            340                 345                 350         


Lys Glu Phe Lys Arg Ala Phe Val Arg Ile Leu Gly Cys Gln Cys Arg 
        355                 360                 365             


Gly Arg Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Leu Gly Gly Cys 
    370                 375                 380                 


Ala Tyr Xaa Tyr Arg Pro Trp Xaa Arg Gly Gly Ser Leu Glu Arg Ser 
385                 390                 395                 400 


Gln Ser Arg Lys Asp Ser Leu Asp Asp Ser Gly Ser Cys Leu Ser Gly 
                405                 410                 415     


Ser Gln Arg Xaa Leu Pro Ser Ala Ser Pro Ser Pro Gly Tyr Leu Gly 
            420                 425                 430         


Arg Gly Ala Pro Pro Pro Val Glu Leu Cys Ala Phe Pro Glu Trp Lys 
        435                 440                 445             


Ala Pro Gly Ala Leu Leu Ser Leu Pro Ala Pro Glu Pro Pro Gly Arg 
    450                 455                 460                 


Arg Gly Arg His Asp Ser Gly Pro Leu Phe Xaa Phe Lys Leu Leu Xaa 
465                 470                 475                 480 


Glu Pro Glu Ser Pro Gly Xaa Asp Gly Gly Ala Ser Asn Gly Gly Cys 
                485                 490                 495     


Glu Ala Ala Ala Asp Val Ala Asn Gly Gln Pro Gly Phe Lys Ser Asn 
            500                 505                 510         


Met Pro Leu Ala Pro Gly Gln Phe 
        515                 520 


<210> 1841
<211> 572
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<400> 1841
Met Xaa Phe Arg Asp Leu Leu Ser Val Ser Phe Glu Gly Pro Arg Pro 
1               5                   10                  15      


Asp Ser Ser Ala Gly Gly Ser Ser Ala Gly Gly Gly Gly Gly Ser Ala 
            20                  25                  30          


Gly Gly Ala Ala Pro Ser Glu Gly Pro Ala Val Gly Gly Val Pro Gly 
        35                  40                  45              


Gly Ala Gly Gly Gly Gly Gly Val Val Gly Ala Gly Ser Gly Glu Asp 
    50                  55                  60                  


Asn Arg Ser Ser Ala Gly Glu Pro Gly Ser Ala Gly Ala Gly Gly Asp 
65                  70                  75                  80  


Val Asn Gly Xaa Ala Ala Val Gly Gly Leu Val Val Ser Ala Gln Gly 
                85                  90                  95      


Val Gly Val Gly Val Phe Leu Ala Ala Phe Ile Leu Met Ala Val Ala 
            100                 105                 110         


Gly Asn Leu Leu Val Ile Leu Ser Val Ala Cys Asn Arg His Leu Gln 
        115                 120                 125             


Xaa Val Xaa Asn Tyr Phe Ile Val Asn Leu Ala Val Ala Asp Leu Leu 
    130                 135                 140                 


Leu Ser Ala Xaa Val Leu Pro Phe Ser Ala Xaa Met Glu Val Leu Gly 
145                 150                 155                 160 


Phe Trp Ala Phe Gly Arg Ala Phe Cys Asp Val Trp Ala Ala Val Asp 
                165                 170                 175     


Val Leu Cys Cys Xaa Ala Ser Ile Leu Ser Leu Cys Xaa Ile Ser Val 
            180                 185                 190         


Asp Arg Tyr Val Gly Val Arg His Ser Leu Lys Tyr Pro Ala Ile Met 
        195                 200                 205             


Xaa Glu Arg Lys Ala Ala Ala Ile Leu Ala Leu Leu Trp Val Val Ala 
    210                 215                 220                 


Leu Val Val Ser Val Gly Pro Leu Leu Gly Trp Lys Glu Pro Val Pro 
225                 230                 235                 240 


Pro Asp Glu Arg Phe Cys Gly Ile Xaa Glu Glu Ala Gly Tyr Ala Val 
                245                 250                 255     


Phe Ser Ser Val Cys Ser Phe Tyr Leu Pro Met Ala Val Ile Val Val 
            260                 265                 270         


Met Tyr Cys Arg Val Tyr Val Val Ala Arg Ser Xaa Xaa Arg Ser Leu 
        275                 280                 285             


Glu Ala Gly Val Lys Arg Glu Arg Gly Lys Ala Ser Glu Val Val Leu 
    290                 295                 300                 


Arg Ile His Cys Arg Gly Ala Ala Xaa Gly Ala Asp Gly Ala His Gly 
305                 310                 315                 320 


Met Arg Ser Ala Lys Gly His Xaa Phe Arg Ser Ser Leu Ser Val Arg 
                325                 330                 335     


Leu Leu Lys Phe Ser Arg Glu Lys Lys Ala Ala Lys Xaa Leu Ala Ile 
            340                 345                 350         


Val Val Gly Val Phe Val Leu Cys Trp Phe Pro Phe Phe Phe Val Leu 
        355                 360                 365             


Pro Leu Gly Ser Leu Phe Pro Gln Leu Lys Pro Ser Glu Gly Val Phe 
    370                 375                 380                 


Lys Val Ile Phe Trp Leu Gly Tyr Phe Asn Ser Cys Val Asn Pro Leu 
385                 390                 395                 400 


Ile Tyr Pro Cys Ser Ser Arg Glu Phe Lys Arg Ala Phe Leu Arg Leu 
                405                 410                 415     


Leu Arg Cys Gln Cys Arg Arg Arg Arg Arg Arg Arg Pro Leu Trp Arg 
            420                 425                 430         


Val Tyr Gly His His Trp Arg Ala Ser Xaa Ser Gly Leu Arg Gln Asp 
        435                 440                 445             


Cys Ala Pro Ser Ser Gly Asp Ala Pro Pro Gly Ala Pro Leu Ala Leu 
    450                 455                 460                 


Xaa Ala Leu Pro Asp Pro Asp Pro Glu Pro Pro Gly Xaa Pro Glu Met 
465                 470                 475                 480 


Gln Ala Pro Val Ala Ser Arg Arg Lys Pro Pro Ser Ala Phe Arg Glu 
                485                 490                 495     


Trp Arg Leu Leu Gly Pro Phe Arg Arg Pro Xaa Xaa Gln Leu Arg Ala 
            500                 505                 510         


Lys Val Ser Ser Leu Ser His Lys Ile Arg Ala Gly Gly Ala Gln Arg 
        515                 520                 525             


Ala Glu Ala Ala Cys Ala Gln Arg Ser Glu Val Glu Ala Val Ser Leu 
    530                 535                 540                 


Gly Val Pro His Glu Val Ala Glu Gly Ala Xaa Cys Gln Ala Tyr Glu 
545                 550                 555                 560 


Leu Ala Asp Tyr Ser Asn Leu Arg Glu Xaa Asp Ile 
                565                 570         


<210> 1842
<211> 465
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<400> 1842
Met Phe Arg Gln Glu Gln Pro Leu Ala Glu Gly Ser Phe Ala Pro Met 
1               5                   10                  15      


Gly Ser Leu Gln Pro Asp Ala Gly Asn Ala Ser Trp Asn Gly Xaa Glu 
            20                  25                  30          


Ala Pro Gly Gly Gly Ala Arg Ala Xaa Pro Tyr Ser Leu Gln Val Xaa 
        35                  40                  45              


Leu Xaa Leu Val Cys Leu Ala Gly Leu Leu Met Leu Leu Xaa Val Phe 
    50                  55                  60                  


Gly Asn Val Leu Val Ile Ile Ala Val Phe Xaa Ser Arg Ala Leu Lys 
65                  70                  75                  80  


Ala Pro Gln Asn Leu Phe Leu Val Ser Leu Ala Ser Ala Asp Ile Leu 
                85                  90                  95      


Val Ala Xaa Leu Val Ile Pro Phe Ser Leu Ala Asn Glu Val Met Gly 
            100                 105                 110         


Tyr Trp Tyr Phe Gly Lys Ala Trp Cys Glu Ile Tyr Leu Ala Leu Asp 
        115                 120                 125             


Val Leu Phe Cys Xaa Ser Ser Ile Val His Leu Cys Ala Ile Ser Leu 
    130                 135                 140                 


Asp Arg Tyr Trp Ser Ile Xaa Gln Ala Ile Glu Tyr Asn Leu Lys Arg 
145                 150                 155                 160 


Xaa Pro Arg Arg Ile Lys Ala Ile Ile Ile Xaa Val Trp Val Ile Ser 
                165                 170                 175     


Ala Val Ile Ser Phe Pro Pro Leu Ile Ser Ile Glu Lys Lys Gly Gly 
            180                 185                 190         


Gly Gly Gly Pro Gln Pro Ala Glu Pro Arg Cys Glu Ile Asn Asp Gln 
        195                 200                 205             


Lys Trp Tyr Val Ile Ser Ser Cys Ile Gly Ser Phe Phe Ala Pro Cys 
    210                 215                 220                 


Leu Ile Met Ile Leu Val Tyr Val Arg Ile Tyr Gln Ile Ala Lys Arg 
225                 230                 235                 240 


Arg Xaa Arg Val Pro Pro Ser Arg Arg Gly Pro Asp Ala Val Ala Ala 
                245                 250                 255     


Pro Pro Gly Gly Xaa Glu Arg Arg Pro Asn Gly Leu Gly Pro Glu Arg 
            260                 265                 270         


Ser Ala Gly Pro Gly Gly Ala Glu Ala Glu Pro Leu Pro Xaa Gln Leu 
        275                 280                 285             


Asn Gly Ala Pro Gly Glu Pro Ala Pro Ala Gly Pro Arg Asp Xaa Asp 
    290                 295                 300                 


Ala Leu Asp Leu Glu Glu Ser Ser Ser Ser Asp His Ala Glu Arg Pro 
305                 310                 315                 320 


Pro Gly Pro Arg Arg Pro Glu Arg Gly Pro Arg Gly Lys Gly Lys Ala 
                325                 330                 335     


Arg Ala Ser Gln Val Lys Pro Gly Asp Ser Leu Pro Arg Arg Gly Pro 
            340                 345                 350         


Gly Ala Xaa Gly Ile Gly Xaa Pro Ala Ala Gly Pro Gly Glu Glu Arg 
        355                 360                 365             


Val Gly Ala Ala Lys Ala Ser Arg Trp Arg Gly Arg Gln Asn Arg Glu 
    370                 375                 380                 


Lys Arg Phe Xaa Phe Val Leu Ala Val Val Ile Gly Val Phe Val Val 
385                 390                 395                 400 


Cys Trp Phe Pro Phe Phe Phe Xaa Tyr Xaa Leu Xaa Ala Val Gly Cys 
                405                 410                 415     


Ser Val Pro Arg Xaa Leu Phe Lys Phe Phe Phe Trp Phe Gly Tyr Cys 
            420                 425                 430         


Asn Ser Ser Leu Asn Pro Val Ile Tyr Xaa Ile Phe Asn His Asp Phe 
        435                 440                 445             


Arg Arg Ala Phe Lys Lys Ile Leu Cys Arg Gly Asp Arg Lys Arg Ile 
    450                 455                 460                 


Val 
465 


<210> 1843
<211> 450
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<400> 1843
Met Asp His Gln Asp Pro Tyr Ser Val Gln Ala Xaa Ala Ala Ile Ala 
1               5                   10                  15      


Ala Ala Ile Xaa Phe Leu Ile Leu Phe Xaa Ile Phe Gly Asn Ala Leu 
            20                  25                  30          


Val Ile Leu Ala Val Leu Xaa Ser Arg Ser Leu Arg Ala Pro Gln Asn 
        35                  40                  45              


Leu Phe Leu Val Ser Leu Ala Ala Ala Asp Ile Leu Val Ala Xaa Leu 
    50                  55                  60                  


Ile Ile Pro Phe Ser Leu Ala Asn Glu Leu Leu Gly Tyr Trp Tyr Phe 
65                  70                  75                  80  


Arg Arg Xaa Trp Cys Glu Val Tyr Leu Ala Leu Asp Val Leu Phe Cys 
                85                  90                  95      


Xaa Ser Ser Ile Val His Leu Cys Ala Ile Ser Leu Asp Arg Tyr Trp 
            100                 105                 110         


Ala Val Ser Arg Ala Leu Glu Tyr Asn Ser Lys Arg Xaa Pro Arg Arg 
        115                 120                 125             


Ile Lys Cys Ile Ile Leu Xaa Val Trp Leu Ile Ala Ala Val Ile Ser 
    130                 135                 140                 


Leu Pro Pro Leu Ile Tyr Lys Gly Asp Gln Gly Pro Gln Pro Arg Gly 
145                 150                 155                 160 


Arg Pro Gln Cys Lys Leu Asn Gln Glu Ala Trp Tyr Ile Leu Ala Ser 
                165                 170                 175     


Ser Ile Gly Ser Phe Phe Ala Pro Cys Leu Ile Met Ile Leu Val Tyr 
            180                 185                 190         


Leu Arg Ile Tyr Leu Ile Ala Lys Arg Ser Asn Arg Arg Gly Pro Arg 
        195                 200                 205             


Ala Lys Gly Gly Pro Gly Gln Gly Glu Ser Lys Gln Pro Arg Pro Asp 
    210                 215                 220                 


His Gly Gly Ala Leu Ala Ser Ala Lys Leu Pro Ala Leu Ala Ser Val 
225                 230                 235                 240 


Ala Ser Ala Arg Glu Val Asn Gly His Ser Lys Ser Xaa Gly Glu Lys 
                245                 250                 255     


Glu Glu Gly Glu Xaa Pro Glu Asp Xaa Gly Xaa Arg Ala Leu Pro Pro 
            260                 265                 270         


Ser Trp Ala Ala Leu Pro Asn Ser Gly Gln Gly Gln Lys Glu Gly Val 
        275                 280                 285             


Cys Gly Ala Ser Pro Glu Asp Glu Ala Glu Glu Glu Glu Glu Glu Glu 
    290                 295                 300                 


Glu Glu Glu Glu Glu Cys Glu Pro Gln Ala Val Pro Val Ser Pro Ala 
305                 310                 315                 320 


Ser Ala Cys Ser Pro Pro Leu Gln Gln Pro Gln Gly Ser Arg Val Leu 
                325                 330                 335     


Ala Xaa Leu Arg Gly Gln Val Leu Leu Gly Arg Gly Val Gly Ala Ile 
            340                 345                 350         


Gly Gly Gln Trp Trp Arg Arg Arg Ala Gln Leu Xaa Arg Glu Lys Arg 
        355                 360                 365             


Phe Xaa Phe Val Leu Ala Val Val Ile Gly Val Phe Val Leu Cys Trp 
    370                 375                 380                 


Phe Pro Phe Phe Phe Ser Tyr Ser Leu Gly Ala Ile Cys Pro Lys His 
385                 390                 395                 400 


Cys Lys Val Pro His Gly Leu Phe Gln Phe Phe Phe Trp Ile Gly Tyr 
                405                 410                 415     


Cys Asn Ser Ser Leu Asn Pro Val Ile Tyr Xaa Ile Phe Asn Gln Asp 
            420                 425                 430         


Phe Arg Arg Ala Phe Arg Arg Ile Leu Cys Arg Pro Trp Xaa Gln Xaa 
        435                 440                 445             


Ala Trp 
    450 


<210> 1844
<211> 374
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<400> 1844
Met Ala Ser Pro Ala Leu Ala Ala Ala Leu Ala Val Ala Ala Ala Ala 
1               5                   10                  15      


Gly Pro Asn Ala Ser Gly Ala Gly Glu Arg Gly Ser Gly Gly Val Ala 
            20                  25                  30          


Asn Ala Ser Gly Ala Ser Trp Gly Pro Pro Arg Gly Gln Tyr Ser Ala 
        35                  40                  45              


Gly Ala Val Ala Gly Leu Ala Ala Val Val Gly Phe Leu Ile Val Phe 
    50                  55                  60                  


Xaa Val Val Gly Asn Val Leu Val Val Ile Ala Val Leu Xaa Ser Arg 
65                  70                  75                  80  


Ala Leu Arg Ala Pro Gln Asn Leu Phe Leu Val Ser Leu Ala Ser Ala 
                85                  90                  95      


Asp Ile Leu Val Ala Xaa Leu Val Met Pro Phe Ser Leu Ala Asn Glu 
            100                 105                 110         


Leu Met Ala Tyr Trp Tyr Phe Gly Gln Val Trp Cys Gly Val Tyr Leu 
        115                 120                 125             


Ala Leu Asp Val Leu Phe Cys Xaa Ser Ser Ile Val His Leu Cys Ala 
    130                 135                 140                 


Ile Ser Leu Asp Arg Tyr Trp Ser Val Xaa Gln Ala Val Glu Tyr Asn 
145                 150                 155                 160 


Leu Lys Arg Xaa Pro Arg Arg Val Lys Ala Xaa Ile Val Ala Val Trp 
                165                 170                 175     


Leu Ile Ser Ala Val Ile Ser Phe Pro Pro Leu Val Ser Leu Tyr Arg 
            180                 185                 190         


Gln Pro Asp Gly Ala Ala Tyr Pro Gln Cys Gly Leu Asn Asp Glu Xaa 
        195                 200                 205             


Trp Tyr Ile Leu Ser Ser Cys Ile Gly Ser Phe Phe Ala Pro Cys Leu 
    210                 215                 220                 


Ile Met Gly Leu Val Tyr Ala Arg Ile Tyr Arg Val Ala Lys Leu Arg 
225                 230                 235                 240 


Xaa Arg Xaa Leu Ser Glu Lys Arg Ala Pro Val Gly Pro Asp Gly Ala 
                245                 250                 255     


Ser Pro Xaa Xaa Glu Asn Gly Leu Gly Ala Ala Ala Gly Ala Gly Glu 
            260                 265                 270         


Asn Gly His Cys Ala Pro Pro Pro Ala Asp Val Glu Pro Asp Glu Ser 
        275                 280                 285             


Ser Ala Ala Ala Glu Arg Arg Arg Arg Arg Gly Ala Leu Arg Arg Gly 
    290                 295                 300                 


Gly Arg Arg Arg Ala Gly Ala Glu Gly Gly Ala Gly Gly Ala Asp Gly 
305                 310                 315                 320 


Gln Gly Ala Gly Pro Gly Ala Ala Glu Ser Gly Ala Leu Xaa Ala Ser 
                325                 330                 335     


Arg Glu Trp Gly Gly Glu Arg Gly Arg Pro Leu Cys Leu Pro Pro Ser 
            340                 345                 350         


Ala Arg Gly Cys Phe Trp Gly Ser Leu Pro Gly Ser Ser Ser Gly Ser 
        355                 360                 365             


Pro Ala Glu Val Trp Leu 
    370                 


<210> 1845
<211> 462
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<400> 1845
Met Ala Ser Pro Ala Leu Ala Ala Ala Leu Ala Val Ala Ala Ala Ala 
1               5                   10                  15      


Gly Pro Asn Ala Ser Gly Ala Gly Glu Arg Gly Ser Gly Gly Val Ala 
            20                  25                  30          


Asn Ala Ser Gly Ala Ser Trp Gly Pro Pro Arg Gly Gln Tyr Ser Ala 
        35                  40                  45              


Gly Ala Val Ala Gly Leu Ala Ala Val Val Gly Phe Leu Ile Val Phe 
    50                  55                  60                  


Xaa Val Val Gly Asn Val Leu Val Val Ile Ala Val Leu Xaa Ser Arg 
65                  70                  75                  80  


Ala Leu Arg Ala Pro Gln Asn Leu Phe Leu Val Ser Leu Ala Ser Ala 
                85                  90                  95      


Asp Ile Leu Val Ala Xaa Leu Val Met Pro Phe Ser Leu Ala Asn Glu 
            100                 105                 110         


Leu Met Ala Tyr Trp Tyr Phe Gly Gln Val Trp Cys Gly Val Tyr Leu 
        115                 120                 125             


Ala Leu Asp Val Leu Phe Cys Xaa Ser Ser Ile Val His Leu Cys Ala 
    130                 135                 140                 


Ile Ser Leu Asp Arg Tyr Trp Ser Val Xaa Gln Ala Val Glu Tyr Asn 
145                 150                 155                 160 


Leu Lys Arg Xaa Pro Arg Arg Val Lys Ala Xaa Ile Val Ala Val Trp 
                165                 170                 175     


Leu Ile Ser Ala Val Ile Ser Phe Pro Pro Leu Val Ser Leu Tyr Arg 
            180                 185                 190         


Gln Pro Asp Gly Ala Ala Tyr Pro Gln Cys Gly Leu Asn Asp Glu Xaa 
        195                 200                 205             


Trp Tyr Ile Leu Ser Ser Cys Ile Gly Ser Phe Phe Ala Pro Cys Leu 
    210                 215                 220                 


Ile Met Gly Leu Val Tyr Ala Arg Ile Tyr Arg Val Ala Lys Leu Arg 
225                 230                 235                 240 


Xaa Arg Xaa Leu Ser Glu Lys Arg Ala Pro Val Gly Pro Asp Gly Ala 
                245                 250                 255     


Ser Pro Xaa Xaa Glu Asn Gly Leu Gly Ala Ala Ala Gly Ala Gly Glu 
            260                 265                 270         


Asn Gly His Cys Ala Pro Pro Pro Ala Asp Val Glu Pro Asp Glu Ser 
        275                 280                 285             


Ser Ala Ala Ala Glu Arg Arg Arg Arg Arg Gly Ala Leu Arg Arg Gly 
    290                 295                 300                 


Gly Arg Arg Arg Ala Gly Ala Glu Gly Gly Ala Gly Gly Ala Asp Gly 
305                 310                 315                 320 


Gln Gly Ala Gly Pro Gly Ala Ala Glu Ser Gly Ala Leu Xaa Ala Ser 
                325                 330                 335     


Arg Ser Pro Gly Pro Gly Gly Arg Leu Ser Arg Ala Ser Ser Arg Ser 
            340                 345                 350         


Val Glu Phe Phe Leu Ser Arg Arg Arg Arg Ala Arg Ser Ser Val Cys 
        355                 360                 365             


Arg Arg Lys Val Ala Gln Ala Arg Glu Lys Arg Phe Xaa Phe Val Leu 
    370                 375                 380                 


Ala Val Val Met Gly Val Phe Val Leu Cys Trp Phe Pro Phe Phe Phe 
385                 390                 395                 400 


Ser Tyr Ser Leu Tyr Gly Ile Cys Arg Glu Ala Cys Gln Val Pro Gly 
                405                 410                 415     


Pro Leu Phe Lys Phe Phe Phe Trp Ile Gly Tyr Cys Asn Ser Ser Leu 
            420                 425                 430         


Asn Pro Val Ile Tyr Xaa Val Phe Asn Gln Asp Phe Arg Arg Ser Phe 
        435                 440                 445             


Lys His Ile Leu Phe Arg Arg Arg Arg Arg Gly Phe Arg Gln 
    450                 455                 460         


<210> 1846
<211> 477
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<400> 1846
Met Gly Ala Gly Val Leu Val Leu Gly Ala Ser Glu Pro Gly Asn Leu 
1               5                   10                  15      


Ser Ser Ala Ala Pro Leu Pro Asp Gly Ala Ala Xaa Ala Ala Arg Leu 
            20                  25                  30          


Leu Val Pro Ala Ser Pro Pro Ala Ser Leu Leu Pro Pro Ala Ser Glu 
        35                  40                  45              


Ser Pro Glu Pro Leu Ser Gln Gln Trp Xaa Ala Gly Met Gly Leu Leu 
    50                  55                  60                  


Met Ala Leu Ile Val Leu Leu Ile Val Ala Gly Asn Val Leu Val Ile 
65                  70                  75                  80  


Val Ala Ile Ala Lys Xaa Pro Arg Leu Gln Xaa Leu Xaa Asn Leu Phe 
                85                  90                  95      


Ile Met Ser Leu Ala Ser Ala Asp Leu Val Met Gly Leu Leu Val Val 
            100                 105                 110         


Pro Phe Gly Ala Xaa Ile Val Val Trp Gly Arg Trp Glu Tyr Gly Ser 
        115                 120                 125             


Phe Phe Cys Glu Leu Trp Xaa Ser Val Asp Val Leu Cys Val Xaa Ala 
    130                 135                 140                 


Ser Ile Glu Xaa Leu Cys Val Ile Ala Leu Asp Arg Tyr Leu Ala Ile 
145                 150                 155                 160 


Xaa Ser Pro Phe Arg Tyr Gln Ser Leu Leu Xaa Arg Ala Arg Ala Arg 
                165                 170                 175     


Gly Leu Val Cys Xaa Val Trp Ala Ile Ser Ala Leu Val Ser Phe Leu 
            180                 185                 190         


Pro Ile Leu Met His Trp Trp Arg Ala Glu Ser Asp Glu Ala Arg Arg 
        195                 200                 205             


Cys Tyr Asn Asp Pro Lys Cys Cys Asp Phe Val Xaa Asn Arg Ala Tyr 
    210                 215                 220                 


Ala Ile Ala Ser Ser Val Val Ser Phe Tyr Val Pro Leu Cys Ile Met 
225                 230                 235                 240 


Ala Phe Val Tyr Leu Arg Val Phe Arg Glu Ala Gln Lys Gln Val Lys 
                245                 250                 255     


Lys Ile Asp Ser Cys Glu Arg Arg Phe Leu Gly Gly Pro Ala Arg Pro 
            260                 265                 270         


Pro Ser Pro Ser Pro Ser Pro Val Pro Ala Pro Ala Pro Pro Pro Gly 
        275                 280                 285             


Pro Pro Arg Pro Ala Ala Ala Ala Ala Xaa Ala Pro Leu Ala Asn Gly 
    290                 295                 300                 


Arg Ala Gly Lys Arg Arg Pro Ser Arg Leu Val Ala Leu Arg Glu Gln 
305                 310                 315                 320 


Lys Ala Leu Lys Xaa Leu Gly Ile Ile Met Gly Val Phe Xaa Leu Cys 
                325                 330                 335     


Trp Leu Pro Phe Phe Leu Ala Asn Val Val Lys Ala Phe His Arg Glu 
            340                 345                 350         


Leu Val Pro Asp Arg Leu Phe Val Phe Phe Asn Trp Leu Gly Tyr Ala 
        355                 360                 365             


Asn Ser Ala Phe Asn Pro Ile Ile Tyr Cys Arg Ser Pro Asp Phe Arg 
    370                 375                 380                 


Lys Ala Phe Gln Gly Leu Leu Cys Cys Ala Arg Arg Ala Ala Arg Arg 
385                 390                 395                 400 


Arg His Ala Xaa His Gly Asp Arg Pro Arg Ala Ser Gly Cys Leu Ala 
                405                 410                 415     


Arg Pro Gly Pro Pro Pro Ser Pro Gly Ala Ala Ser Asp Asp Asp Asp 
            420                 425                 430         


Asp Asp Val Val Gly Ala Xaa Pro Pro Ala Arg Leu Leu Glu Pro Trp 
        435                 440                 445             


Ala Gly Cys Asn Gly Gly Ala Ala Ala Asp Ser Asp Ser Ser Leu Asp 
    450                 455                 460                 


Glu Pro Cys Arg Pro Gly Phe Ala Ser Glu Ser Lys Val 
465                 470                 475         


<210> 1847
<211> 413
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<400> 1847
Met Gly Gln Pro Gly Asn Gly Ser Ala Phe Leu Leu Ala Pro Asn Gly 
1               5                   10                  15      


Ser His Ala Pro Asp His Asp Val Xaa Gln Glu Arg Asp Glu Val Trp 
            20                  25                  30          


Val Val Gly Met Gly Ile Val Met Ser Leu Ile Val Leu Ala Ile Val 
        35                  40                  45              


Phe Gly Asn Val Leu Val Ile Xaa Ala Ile Ala Lys Phe Glu Arg Leu 
    50                  55                  60                  


Gln Xaa Val Xaa Asn Tyr Phe Ile Xaa Ser Leu Ala Cys Ala Asp Leu 
65                  70                  75                  80  


Val Met Gly Leu Ala Val Val Pro Phe Gly Ala Ala His Ile Leu Met 
                85                  90                  95      


Lys Met Trp Xaa Phe Gly Asn Phe Trp Cys Glu Phe Trp Xaa Ser Ile 
            100                 105                 110         


Asp Val Leu Cys Val Xaa Ala Ser Ile Glu Xaa Leu Cys Val Ile Ala 
        115                 120                 125             


Val Asp Arg Tyr Phe Ala Ile Xaa Ser Pro Phe Lys Tyr Gln Ser Leu 
    130                 135                 140                 


Leu Xaa Lys Asn Lys Ala Arg Val Ile Ile Leu Met Val Trp Ile Val 
145                 150                 155                 160 


Ser Gly Leu Xaa Ser Phe Leu Pro Ile Gln Met His Trp Tyr Arg Ala 
                165                 170                 175     


Xaa His Gln Glu Ala Ile Asn Cys Tyr Ala Asn Glu Xaa Cys Cys Asp 
            180                 185                 190         


Phe Phe Xaa Asn Gln Ala Tyr Ala Ile Ala Ser Ser Ile Val Ser Phe 
        195                 200                 205             


Tyr Val Pro Leu Val Ile Met Val Phe Val Tyr Ser Arg Val Phe Gln 
    210                 215                 220                 


Glu Ala Lys Arg Gln Leu Gln Lys Ile Asp Lys Ser Glu Gly Arg Phe 
225                 230                 235                 240 


His Val Gln Asn Leu Ser Gln Val Glu Gln Asp Gly Arg Xaa Gly His 
                245                 250                 255     


Gly Leu Arg Arg Ser Ser Lys Phe Cys Leu Lys Glu His Lys Ala Leu 
            260                 265                 270         


Lys Xaa Leu Gly Ile Ile Met Gly Xaa Phe Xaa Leu Cys Trp Leu Pro 
        275                 280                 285             


Phe Phe Ile Val Asn Ile Val His Val Ile Gln Asp Asn Leu Ile Arg 
    290                 295                 300                 


Lys Glu Val Tyr Ile Leu Leu Asn Trp Ile Gly Tyr Val Asn Ser Gly 
305                 310                 315                 320 


Phe Asn Pro Leu Ile Tyr Cys Arg Ser Pro Asp Phe Arg Ile Ala Phe 
                325                 330                 335     


Gln Glu Leu Leu Cys Leu Arg Arg Ser Ser Leu Lys Ala Tyr Gly Asn 
            340                 345                 350         


Gly Tyr Ser Ser Asn Gly Asn Xaa Gly Glu Gln Ser Gly Tyr His Val 
        355                 360                 365             


Glu Gln Glu Lys Glu Asn Lys Leu Leu Cys Glu Asp Leu Pro Gly Xaa 
    370                 375                 380                 


Glu Asp Phe Val Gly His Gln Gly Xaa Val Pro Ser Asp Asn Ile Asp 
385                 390                 395                 400 


Ser Gln Gly Arg Asn Cys Ser Xaa Asn Asp Ser Leu Leu 
                405                 410             


<210> 1848
<211> 408
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<400> 1848
Met Ala Pro Trp Pro His Glu Asn Ser Ser Leu Ala Pro Trp Pro Asp 
1               5                   10                  15      


Leu Pro Xaa Leu Ala Pro Asn Xaa Ala Asn Xaa Ser Gly Leu Pro Gly 
            20                  25                  30          


Val Pro Trp Glu Ala Ala Leu Ala Gly Ala Leu Leu Ala Leu Ala Val 
        35                  40                  45              


Leu Ala Xaa Val Gly Gly Asn Leu Leu Val Ile Val Ala Ile Ala Trp 
    50                  55                  60                  


Xaa Pro Arg Leu Gln Xaa Met Xaa Asn Val Phe Val Xaa Ser Leu Ala 
65                  70                  75                  80  


Ala Ala Asp Leu Val Met Gly Leu Leu Val Val Pro Pro Ala Ala Xaa 
                85                  90                  95      


Leu Ala Leu Xaa Gly His Trp Pro Leu Gly Ala Xaa Gly Cys Glu Leu 
            100                 105                 110         


Trp Xaa Ser Val Asp Val Leu Cys Val Xaa Ala Ser Ile Glu Xaa Leu 
        115                 120                 125             


Cys Ala Leu Ala Val Asp Arg Tyr Leu Ala Val Xaa Asn Pro Leu Arg 
    130                 135                 140                 


Tyr Gly Ala Leu Val Xaa Lys Arg Cys Ala Arg Xaa Ala Val Val Leu 
145                 150                 155                 160 


Val Trp Val Val Ser Ala Ala Val Ser Phe Ala Pro Ile Met Ser Gln 
                165                 170                 175     


Trp Trp Arg Val Gly Ala Asp Ala Glu Ala Gln Arg Cys His Ser Asn 
            180                 185                 190         


Pro Arg Cys Cys Ala Phe Ala Ser Asn Met Pro Tyr Val Leu Leu Ser 
        195                 200                 205             


Ser Ser Val Ser Phe Tyr Leu Pro Leu Leu Val Met Leu Phe Val Tyr 
    210                 215                 220                 


Ala Arg Val Phe Val Val Ala Xaa Arg Gln Leu Arg Leu Leu Arg Gly 
225                 230                 235                 240 


Glu Leu Gly Arg Phe Pro Pro Glu Glu Ser Pro Pro Ala Pro Ser Arg 
                245                 250                 255     


Ser Leu Ala Pro Ala Pro Val Gly Xaa Cys Ala Pro Pro Glu Gly Val 
            260                 265                 270         


Pro Ala Cys Gly Arg Arg Pro Ala Arg Leu Leu Pro Leu Arg Glu His 
        275                 280                 285             


Arg Ala Leu Cys Xaa Leu Gly Leu Ile Met Gly Xaa Phe Xaa Leu Cys 
    290                 295                 300                 


Trp Leu Pro Phe Phe Leu Ala Asn Val Leu Arg Ala Leu Gly Gly Pro 
305                 310                 315                 320 


Ser Leu Val Pro Gly Pro Ala Phe Leu Ala Leu Asn Trp Leu Gly Tyr 
                325                 330                 335     


Ala Asn Ser Ala Phe Asn Pro Leu Ile Tyr Cys Arg Ser Pro Asp Phe 
            340                 345                 350         


Arg Ser Ala Phe Arg Arg Leu Leu Cys Arg Cys Gly Arg Arg Leu Pro 
        355                 360                 365             


Pro Glu Pro Cys Ala Ala Ala Arg Pro Ala Leu Phe Pro Ser Gly Val 
    370                 375                 380                 


Pro Ala Ala Arg Ser Ser Pro Ala Gln Pro Arg Leu Cys Gln Arg Leu 
385                 390                 395                 400 


Asp Gly Ala Ser Trp Gly Val Ser 
                405             


<210> 1849
<211> 69
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<400> 1849
Lys Pro Asp Ala Glu Arg Gln Xaa Asp Glu Glu Lys Glu Glu Leu Lys 
1               5                   10                  15      


Lys Pro Lys Lys Glu Asp Ser Ser Pro Lys Glu Glu Xaa Asp Lys Trp 
            20                  25                  30          


Ala Val Glu Lys Gly Lys Asp His Lys Glu Pro Arg Lys Gly Glu Glu 
        35                  40                  45              


Leu Glu Glu Glu Trp Xaa Pro Xaa Glu Lys Val Arg Pro Leu Cys Arg 
    50                  55                  60                  


Arg Ser Pro Ser Gly 
65                  


<210> 1850
<211> 54
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<400> 1850
Leu Met Lys Val Val Asn Glu Glu Cys Pro Xaa Ile Xaa Arg Xaa Tyr 
1               5                   10                  15      


Ser Leu Gly Lys Ser Ser Arg Gly Leu Lys Ile Tyr Ala Met Glu Ile 
            20                  25                  30          


Ser Asp Asn Pro Gly Glu His Glu Leu Gly Glu Gly Leu Trp Gly Pro 
        35                  40                  45              


Ala Ala Gly Leu Cys Cys 
    50                  


<210> 1851
<211> 1158
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1083)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1091)..(1091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1103)..(1103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1152)..(1152)
<223> Selenocysteine

<400> 1851
Met Ala Ala Val Arg Gly Ala Pro Leu Leu Ser Cys Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Leu Cys Pro Gly Gly Arg Pro Gln Xaa Val Leu Xaa Asp Asp 
            20                  25                  30          


Glu Ile Glu Glu Phe Leu Glu Gly Phe Leu Ser Glu Leu Glu Pro Glu 
        35                  40                  45              


Pro Arg Glu Asp Asp Val Glu Ala Pro Pro Pro Pro Glu Pro Xaa Pro 
    50                  55                  60                  


Arg Val Arg Lys Ala Gln Ala Gly Gly Lys Pro Gly Lys Arg Pro Gly 
65                  70                  75                  80  


Xaa Ala Ala Glu Val Pro Pro Glu Lys Xaa Lys Asp Lys Gly Lys Lys 
                85                  90                  95      


Gly Lys Lys Asp Lys Gly Pro Lys Val Pro Lys Glu Ser Leu Glu Gly 
            100                 105                 110         


Ser Pro Arg Pro Pro Lys Lys Gly Lys Glu Lys Pro Pro Lys Ala Xaa 
        115                 120                 125             


Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Xaa Lys Lys Pro Lys Glu 
    130                 135                 140                 


Lys Pro Pro Lys Ala Xaa Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala 
145                 150                 155                 160 


Xaa Lys Lys Pro Pro Ser Gly Lys Arg Pro Pro Ile Leu Ala Pro Ser 
                165                 170                 175     


Glu Xaa Leu Glu Trp Pro Leu Pro Pro Pro Pro Ser Pro Gly Pro Glu 
            180                 185                 190         


Glu Leu Pro Gln Glu Gly Gly Ala Pro Leu Ser Asn Asn Trp Gln Asn 
        195                 200                 205             


Pro Gly Glu Glu Xaa His Val Glu Ala Arg Glu His Gln Pro Glu Pro 
    210                 215                 220                 


Glu Glu Glu Xaa Glu Gln Pro Xaa Leu Asp Tyr Asn Asp Gln Ile Glu 
225                 230                 235                 240 


Arg Glu Asp Tyr Glu Asp Phe Glu Tyr Ile Arg Arg Gln Lys Gln Pro 
                245                 250                 255     


Arg Pro Pro Pro Ser Arg Arg Arg Arg Pro Glu Arg Val Trp Pro Glu 
            260                 265                 270         


Pro Pro Glu Glu Lys Ala Pro Ala Pro Ala Pro Glu Glu Arg Ile Glu 
        275                 280                 285             


Pro Pro Val Lys Pro Leu Leu Pro Pro Leu Pro Pro Asp Tyr Gly Asp 
    290                 295                 300                 


Gly Tyr Val Ile Pro Asn Tyr Asp Asp Met Asp Tyr Tyr Phe Gly Pro 
305                 310                 315                 320 


Pro Pro Pro Gln Lys Pro Asp Ala Glu Arg Gln Xaa Asp Glu Glu Lys 
                325                 330                 335     


Glu Glu Leu Lys Lys Pro Lys Lys Glu Asp Ser Ser Pro Lys Glu Glu 
            340                 345                 350         


Xaa Asp Lys Trp Ala Val Glu Lys Gly Lys Asp His Lys Glu Pro Arg 
        355                 360                 365             


Lys Gly Glu Glu Leu Glu Glu Glu Trp Xaa Pro Xaa Glu Lys Val Lys 
    370                 375                 380                 


Cys Pro Pro Ile Gly Met Glu Ser His Arg Ile Glu Asp Asn Gln Ile 
385                 390                 395                 400 


Arg Ala Ser Ser Met Leu Arg His Gly Leu Gly Ala Gln Arg Gly Arg 
                405                 410                 415     


Leu Asn Met Gln Xaa Gly Ala Xaa Glu Asp Asp Tyr Tyr Asp Gly Ala 
            420                 425                 430         


Trp Cys Ala Glu Asp Asp Ala Arg Xaa Gln Trp Ile Glu Val Asp Xaa 
        435                 440                 445             


Arg Arg Xaa Xaa Arg Phe Xaa Gly Val Ile Xaa Gln Gly Arg Asp Ser 
    450                 455                 460                 


Ser Ile His Asp Asp Phe Val Xaa Xaa Phe Phe Val Gly Phe Ser Asn 
465                 470                 475                 480 


Asp Ser Gln Xaa Trp Val Met Tyr Xaa Asn Gly Tyr Glu Glu Met Xaa 
                485                 490                 495     


Phe His Gly Asn Val Asp Lys Asp Xaa Pro Val Leu Ser Glu Leu Pro 
            500                 505                 510         


Glu Pro Val Val Ala Arg Phe Ile Arg Ile Tyr Pro Leu Xaa Trp Asn 
        515                 520                 525             


Gly Ser Leu Cys Met Arg Leu Glu Val Leu Gly Cys Ser Val Ala Pro 
    530                 535                 540                 


Val Tyr Ser Tyr Tyr Ala Gln Asn Glu Val Val Ala Xaa Asp Asp Leu 
545                 550                 555                 560 


Asp Phe Arg His His Ser Tyr Lys Asp Met Arg Gln Leu Met Lys Val 
                565                 570                 575     


Val Asn Glu Glu Cys Pro Xaa Ile Xaa Arg Xaa Tyr Ser Leu Gly Lys 
            580                 585                 590         


Ser Ser Arg Gly Leu Lys Ile Tyr Ala Met Glu Ile Ser Asp Asn Pro 
        595                 600                 605             


Gly Glu His Glu Leu Gly Glu Pro Glu Phe Arg Tyr Xaa Ala Gly Ile 
    610                 615                 620                 


His Gly Asn Glu Val Leu Gly Arg Glu Leu Leu Leu Leu Leu Met Gln 
625                 630                 635                 640 


Tyr Leu Cys Arg Glu Tyr Arg Asp Gly Asn Pro Arg Val Arg Ser Leu 
                645                 650                 655     


Val Gln Asp Xaa Arg Ile His Leu Val Pro Ser Leu Asn Pro Asp Gly 
            660                 665                 670         


Tyr Glu Val Ala Ala Gln Met Gly Ser Glu Phe Gly Asn Trp Ala Leu 
        675                 680                 685             


Gly Leu Trp Xaa Glu Glu Gly Phe Asp Ile Phe Glu Asp Phe Pro Asp 
    690                 695                 700                 


Leu Asn Ser Val Leu Trp Gly Ala Glu Glu Arg Lys Trp Val Pro Tyr 
705                 710                 715                 720 


Arg Val Pro Asn Asn Asn Leu Pro Ile Pro Glu Arg Tyr Leu Ser Pro 
                725                 730                 735     


Asp Ala Xaa Val Ser Xaa Glu Val Arg Ala Ile Ile Ala Trp Met Glu 
            740                 745                 750         


Lys Asn Pro Phe Val Leu Gly Ala Asn Leu Asn Gly Gly Glu Arg Leu 
        755                 760                 765             


Val Ser Tyr Pro Tyr Asp Met Ala Arg Xaa Pro Xaa Gln Glu Gln Leu 
    770                 775                 780                 


Leu Ala Ala Ala Met Ala Ala Ala Arg Gly Glu Asp Glu Asp Glu Val 
785                 790                 795                 800 


Ser Glu Ala Gln Glu Xaa Pro Asp His Ala Ile Phe Arg Trp Leu Ala 
                805                 810                 815     


Ile Ser Phe Ala Ser Ala His Leu Xaa Leu Xaa Glu Pro Tyr Arg Gly 
            820                 825                 830         


Gly Cys Gln Ala Gln Asp Tyr Xaa Gly Gly Met Gly Ile Val Asn Gly 
        835                 840                 845             


Ala Lys Trp Asn Pro Arg Xaa Gly Xaa Ile Asn Asp Phe Ser Tyr Leu 
    850                 855                 860                 


His Xaa Asn Cys Leu Glu Leu Ser Phe Tyr Leu Gly Cys Asp Lys Phe 
865                 870                 875                 880 


Pro His Glu Ser Glu Leu Pro Arg Glu Trp Glu Asn Asn Lys Glu Ala 
                885                 890                 895     


Leu Leu Xaa Phe Met Glu Gln Val His Arg Gly Ile Lys Gly Val Val 
            900                 905                 910         


Xaa Asp Glu Gln Gly Ile Pro Ile Ala Asn Ala Xaa Ile Ser Val Ser 
        915                 920                 925             


Gly Ile Asn His Gly Val Lys Xaa Ala Ser Gly Gly Asp Tyr Trp Arg 
    930                 935                 940                 


Ile Leu Asn Pro Gly Glu Tyr Arg Val Xaa Ala His Ala Glu Gly Tyr 
945                 950                 955                 960 


Xaa Pro Ser Ala Lys Xaa Cys Asn Val Asp Tyr Asp Ile Gly Ala Xaa 
                965                 970                 975     


Gln Cys Asn Phe Ile Leu Ala Arg Ser Asn Trp Lys Arg Ile Arg Glu 
            980                 985                 990         


Ile Met Ala Met Asn Gly Asn Arg  Pro Ile Pro His Ile  Asp Pro Ser 
        995                 1000                 1005             


Arg Pro  Met Xaa Pro Gln Gln  Arg Arg Leu Gln Gln  Arg Arg Leu 
    1010                 1015                 1020             


Gln His  Arg Leu Arg Leu Arg  Ala Gln Met Arg Leu  Arg Arg Leu 
    1025                 1030                 1035             


Asn Ala  Xaa Xaa Xaa Leu Gly  Pro His Xaa Val Pro  Pro Xaa Leu 
    1040                 1045                 1050             


Pro Pro  Ala Pro Ala Xaa Xaa  Leu Ser Xaa Xaa Ile  Glu Pro Trp 
    1055                 1060                 1065             


Gly Leu  Ile Pro Pro Xaa Xaa  Ala Gly Trp Glu Glu  Ser Glu Xaa 
    1070                 1075                 1080             


Glu Xaa  Tyr Xaa Glu Val Val  Xaa Glu Phe Gly Xaa  Glu Val Glu 
    1085                 1090                 1095             


Pro Glu  Phe Gly Xaa Lys Val  Glu Pro Glu Phe Glu  Xaa Gln Leu 
    1100                 1105                 1110             


Glu Pro  Glu Phe Glu Xaa Gln  Leu Glu Pro Glu Phe  Glu Glu Glu 
    1115                 1120                 1125             


Glu Glu  Glu Glu Lys Glu Glu  Glu Ile Ala Xaa Gly  Gln Ala Phe 
    1130                 1135                 1140             


Pro Phe  Xaa Xaa Val Glu Xaa  Tyr Xaa Val Asn Phe  Gly Asp Phe 
    1145                 1150                 1155             


<210> 1852
<211> 162
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 1852
Met Pro Pro Glu Lys Xaa Lys Asp Lys Gly Lys Lys Gly Lys Lys Asp 
1               5                   10                  15      


Lys Gly Pro Lys Val Pro Lys Glu Ser Leu Glu Gly Ser Pro Arg Pro 
            20                  25                  30          


Pro Lys Lys Gly Lys Glu Lys Pro Pro Lys Ala Xaa Lys Lys Pro Lys 
        35                  40                  45              


Glu Lys Pro Pro Lys Ala Xaa Lys Lys Pro Lys Glu Lys Pro Pro Lys 
    50                  55                  60                  


Ala Xaa Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Xaa Lys Lys Pro 
65                  70                  75                  80  


Pro Ser Gly Lys Arg Pro Pro Ile Leu Ala Pro Ser Glu Xaa Leu Glu 
                85                  90                  95      


Trp Pro Leu Pro Pro Pro Pro Ser Pro Gly Pro Glu Glu Leu Pro Gln 
            100                 105                 110         


Glu Gly Gly Ala Pro Leu Ser Asn Asn Trp Gln Asn Pro Gly Glu Glu 
        115                 120                 125             


Xaa His Val Glu Ala Arg Glu His Gln Pro Glu Pro Glu Glu Glu Xaa 
    130                 135                 140                 


Glu Gln Pro Xaa Leu Asp Tyr Asn Asp Gln Ile Glu Arg Glu Asp Tyr 
145                 150                 155                 160 


Glu Asp 
        


<210> 1853
<211> 733
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<400> 1853
Met Arg Lys Trp Trp Ala Pro Cys Pro Gly Ser Trp Leu Cys Ser His 
1               5                   10                  15      


Cys Leu Gly Glu Gly Trp Ala Leu Arg Gly Ala Gly Ser Xaa Ala Leu 
            20                  25                  30          


Arg Pro Ala Ser Pro Gln Xaa Phe His Gly Asn Val Asp Lys Asp Xaa 
        35                  40                  45              


Pro Val Leu Ser Glu Leu Pro Glu Pro Val Val Ala Arg Phe Ile Arg 
    50                  55                  60                  


Ile Tyr Pro Leu Xaa Trp Asn Gly Ser Leu Cys Met Arg Leu Glu Val 
65                  70                  75                  80  


Leu Gly Cys Ser Val Ala Arg Glu Cys Gly Gly Leu Ala Gly Ala Leu 
                85                  90                  95      


Ser Gly Gly Gly Val Leu Gly Trp Ala Ser Arg His Pro Ala Lys Asp 
            100                 105                 110         


Asn Pro Ala Ser Leu Ala Ala Val Tyr Ser Tyr Tyr Ala Gln Asn Glu 
        115                 120                 125             


Val Val Ala Xaa Asp Asp Leu Asp Phe Arg His His Ser Tyr Lys Asp 
    130                 135                 140                 


Met Arg Gln Leu Met Lys Val Val Asn Glu Glu Cys Pro Xaa Ile Xaa 
145                 150                 155                 160 


Arg Xaa Tyr Ser Leu Gly Lys Ser Ser Arg Gly Leu Lys Ile Tyr Ala 
                165                 170                 175     


Met Glu Ile Ser Asp Asn Pro Gly Glu His Glu Leu Gly Glu Pro Glu 
            180                 185                 190         


Phe Arg Tyr Xaa Ala Gly Ile His Gly Asn Glu Val Leu Gly Arg Glu 
        195                 200                 205             


Leu Leu Leu Leu Leu Met Gln Tyr Leu Cys Arg Glu Tyr Arg Asp Gly 
    210                 215                 220                 


Asn Pro Arg Val Arg Ser Leu Val Gln Asp Xaa Arg Ile His Leu Val 
225                 230                 235                 240 


Pro Ser Leu Asn Pro Asp Gly Tyr Glu Val Ala Ala Gln Met Gly Ser 
                245                 250                 255     


Glu Phe Gly Asn Trp Ala Leu Gly Leu Trp Xaa Glu Glu Gly Phe Asp 
            260                 265                 270         


Ile Phe Glu Asp Phe Pro Asp Leu Asn Ser Val Leu Trp Gly Ala Glu 
        275                 280                 285             


Glu Arg Lys Trp Val Pro Tyr Arg Val Pro Asn Asn Asn Leu Pro Ile 
    290                 295                 300                 


Pro Glu Arg Tyr Leu Ser Pro Asp Ala Xaa Val Ser Xaa Glu Val Arg 
305                 310                 315                 320 


Ala Ile Ile Ala Trp Met Glu Lys Asn Pro Phe Val Leu Gly Ala Asn 
                325                 330                 335     


Leu Asn Gly Gly Glu Arg Leu Val Ser Tyr Pro Tyr Asp Met Ala Arg 
            340                 345                 350         


Xaa Pro Xaa Gln Glu Gln Leu Leu Ala Ala Ala Met Ala Ala Ala Arg 
        355                 360                 365             


Gly Glu Asp Glu Asp Glu Val Ser Glu Ala Gln Glu Xaa Pro Asp His 
    370                 375                 380                 


Ala Ile Phe Arg Trp Leu Ala Ile Ser Phe Ala Ser Ala His Leu Xaa 
385                 390                 395                 400 


Leu Xaa Glu Pro Tyr Arg Gly Gly Cys Gln Ala Gln Asp Tyr Xaa Gly 
                405                 410                 415     


Gly Met Gly Ile Val Asn Gly Ala Lys Trp Asn Pro Arg Xaa Gly Xaa 
            420                 425                 430         


Ile Asn Asp Phe Ser Tyr Leu His Xaa Asn Cys Leu Glu Leu Ser Phe 
        435                 440                 445             


Tyr Leu Gly Cys Asp Lys Phe Pro His Glu Ser Glu Leu Pro Arg Glu 
    450                 455                 460                 


Trp Glu Asn Asn Lys Glu Ala Leu Leu Xaa Phe Met Glu Gln Val His 
465                 470                 475                 480 


Arg Gly Ile Lys Gly Val Val Xaa Asp Glu Gln Gly Ile Pro Ile Ala 
                485                 490                 495     


Asn Ala Xaa Ile Ser Val Ser Gly Ile Asn His Gly Val Lys Xaa Ala 
            500                 505                 510         


Ser Gly Gly Asp Tyr Trp Arg Ile Leu Asn Pro Gly Glu Tyr Arg Val 
        515                 520                 525             


Xaa Ala His Ala Glu Gly Tyr Xaa Pro Ser Ala Lys Xaa Cys Asn Val 
    530                 535                 540                 


Asp Tyr Asp Ile Gly Ala Xaa Gln Cys Asn Phe Ile Leu Ala Arg Ser 
545                 550                 555                 560 


Asn Trp Lys Arg Ile Arg Glu Ile Met Ala Met Asn Gly Asn Arg Pro 
                565                 570                 575     


Ile Pro His Ile Asp Pro Ser Arg Pro Met Xaa Pro Gln Gln Arg Arg 
            580                 585                 590         


Leu Gln Gln Arg Arg Leu Gln His Arg Leu Arg Leu Arg Ala Gln Met 
        595                 600                 605             


Arg Leu Arg Arg Leu Asn Ala Xaa Xaa Xaa Leu Gly Pro His Xaa Val 
    610                 615                 620                 


Pro Pro Xaa Leu Pro Pro Ala Pro Ala Xaa Xaa Leu Ser Xaa Xaa Ile 
625                 630                 635                 640 


Glu Pro Trp Gly Leu Ile Pro Pro Xaa Xaa Ala Gly Trp Glu Glu Ser 
                645                 650                 655     


Glu Xaa Glu Xaa Tyr Xaa Glu Val Val Xaa Glu Phe Gly Xaa Glu Val 
            660                 665                 670         


Glu Pro Glu Phe Gly Xaa Lys Val Glu Pro Glu Phe Glu Xaa Gln Leu 
        675                 680                 685             


Glu Pro Glu Phe Glu Xaa Gln Leu Glu Pro Glu Phe Glu Glu Glu Glu 
    690                 695                 700                 


Glu Glu Glu Lys Glu Glu Glu Ile Ala Xaa Gly Gln Ala Phe Pro Phe 
705                 710                 715                 720 


Xaa Xaa Val Glu Xaa Tyr Xaa Val Asn Phe Gly Asp Phe 
                725                 730             


<210> 1854
<211> 104
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<400> 1854
Arg Xaa Gln Trp Ile Glu Val Asp Xaa Arg Arg Xaa Xaa Arg Phe Xaa 
1               5                   10                  15      


Gly Val Ile Xaa Gln Gly Arg Asp Ser Ser Ile His Asp Asp Phe Val 
            20                  25                  30          


Xaa Xaa Phe Phe Val Gly Phe Ser Asn Asp Ser Gln Xaa Trp Val Met 
        35                  40                  45              


Tyr Xaa Asn Gly Tyr Glu Glu Met Val Gly Xaa Met Pro Arg Leu Leu 
    50                  55                  60                  


Ala Leu Leu Pro Leu Ser Gly Arg Gly Val Gly Ser Gln Arg Gly Trp 
65                  70                  75                  80  


Gln Tyr Cys Ser Glu Ala Cys Leu Ser Pro Asp Leu Ser Trp Glu Arg 
                85                  90                  95      


Gly Gln Gly His Xaa Arg Ala Glu 
            100                 


<210> 1855
<211> 251
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<400> 1855
Xaa Glu Leu Glu Pro Glu Pro Arg Glu Asp Asp Val Glu Ala Pro Pro 
1               5                   10                  15      


Pro Pro Glu Pro Xaa Pro Arg Val Arg Lys Ala Gln Ala Gly Gly Lys 
            20                  25                  30          


Pro Gly Lys Arg Pro Gly Xaa Ala Ala Glu Val Pro Pro Glu Lys Xaa 
        35                  40                  45              


Lys Asp Lys Gly Lys Lys Gly Lys Lys Asp Lys Gly Pro Lys Val Pro 
    50                  55                  60                  


Lys Glu Ser Leu Glu Gly Ser Pro Arg Pro Pro Lys Lys Gly Lys Glu 
65                  70                  75                  80  


Lys Pro Pro Lys Ala Xaa Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala 
                85                  90                  95      


Xaa Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Xaa Lys Lys Pro Lys 
            100                 105                 110         


Glu Lys Pro Pro Lys Ala Xaa Lys Lys Pro Pro Ser Gly Lys Arg Pro 
        115                 120                 125             


Pro Ile Leu Ala Pro Ser Glu Xaa Leu Glu Trp Pro Leu Pro Pro Pro 
    130                 135                 140                 


Pro Ser Pro Gly Pro Glu Glu Leu Pro Gln Glu Gly Gly Ala Pro Leu 
145                 150                 155                 160 


Ser Asn Asn Trp Gln Asn Pro Gly Glu Glu Xaa His Val Glu Ala Arg 
                165                 170                 175     


Glu His Gln Pro Glu Pro Pro Val Lys Pro Leu Leu Pro Pro Leu Pro 
            180                 185                 190         


Pro Asp Tyr Gly Asp Gly Tyr Val Ile Pro Asn Tyr Asp Asp Met Asp 
        195                 200                 205             


Tyr Tyr Phe Gly Pro Pro Pro Pro Gln Lys Pro Asp Ala Glu Arg Gln 
    210                 215                 220                 


Xaa Asp Glu Glu Lys Glu Glu Leu Lys Lys Pro Lys Lys Glu Asp Ser 
225                 230                 235                 240 


Ser Pro Lys Glu Glu Xaa Asp Lys Trp Ala Val 
                245                 250     


<210> 1856
<211> 66
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 1856
Xaa Phe Arg His His Ser Tyr Lys Asp Met Arg Gln Leu Met Lys Val 
1               5                   10                  15      


Val Asn Glu Glu Cys Pro Xaa Ile Xaa Arg Xaa Tyr Ser Leu Gly Lys 
            20                  25                  30          


Ser Ser Arg Gly Leu Lys Ile Tyr Ala Met Glu Ile Ser Asp Asn Pro 
        35                  40                  45              


Gly Glu His Glu Leu Gly Glu Gly Leu Trp Gly Pro Ala Ala Gly Leu 
    50                  55                  60                  


Cys Cys 
65      


<210> 1857
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<400> 1857
Leu Ala Arg Pro His Asp Phe Phe Asp Ala Gln Xaa Leu Asp Ala Ile 
1               5                   10                  15      


Arg His Arg Ala Ile Cys Phe Asn Leu Ser Ala His Ile Glu Ser Leu 
            20                  25                  30          


Gly Lys Gly His Ser Val Val Phe His Ser Xaa Val Ile Ala Lys Arg 
        35                  40                  45              


Lys Glu Asp Ser Gly Lys Ile Lys Leu Leu Leu His Trp Met Pro Glu 
    50                  55                  60                  


Asp Ile Leu Pro Asp Val Trp Val Asn Glu Ser Glu Arg His Gln Leu 
65                  70                  75                  80  


Lys Xaa Lys Val Val His Leu Ser Lys Leu Pro Lys Asp Xaa Ala Leu 
                85                  90                  95      


Leu Leu Asp Pro Asn Ile Tyr Arg Xaa Met Pro Gln Lys Arg Leu Lys 
            100                 105                 110         


Arg Ser Asp Lys Pro Phe Xaa Phe Cys His Asp Cys Glu Ala Ser Ser 
        115                 120                 125             


Ala Met 
    130 


<210> 1858
<211> 140
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<400> 1858
Leu Asp Ala Ile Arg His Arg Ala Ile Cys Phe Asn Leu Ser Ala His 
1               5                   10                  15      


Ile Glu Ser Leu Gly Lys Gly His Ser Val Val Phe His Ser Xaa Val 
            20                  25                  30          


Ile Ala Lys Arg Lys Glu Asp Ser Gly Lys Ile Lys Leu Leu Leu His 
        35                  40                  45              


Trp Met Pro Glu Asp Ile Leu Pro Asp Val Trp Val Asn Glu Ser Glu 
    50                  55                  60                  


Arg His Gln Leu Lys Xaa Lys Val Val His Leu Ser Lys Leu Pro Lys 
65                  70                  75                  80  


Asp Xaa Ala Leu Leu Leu Asp Pro Asn Ile Tyr Arg Xaa Met Pro Gln 
                85                  90                  95      


Lys Arg Leu Lys Arg Trp Ser Phe Xaa Leu Val Ala Gln Ala Gly Val 
            100                 105                 110         


Gln Trp Arg Asp Leu Gly Ser Pro Gln Pro Pro Leu Pro Gly Phe Lys 
        115                 120                 125             


Arg Phe Phe Cys Leu Ser Phe Leu Ser Ser Trp Asp 
    130                 135                 140 


<210> 1859
<211> 503
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<400> 1859
Met Ala Ala Ala Ile Xaa Asp Met Ala Asp Leu Glu Glu Leu Ser Arg 
1               5                   10                  15      


Leu Ser Pro Leu Pro Pro Gly Ser Pro Gly Ser Ala Ala Arg Gly Arg 
            20                  25                  30          


Ala Glu Pro Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        35                  40                  45              


Ala Glu Ala Glu Ala Val Ala Ala Leu Leu Leu Asn Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Val Gly Gly Gly Glu Ala Glu 
65                  70                  75                  80  


Xaa Met Ser Glu Pro Ser Pro Glu Ser Ala Ser Gln Ala Gly Glu Asp 
                85                  90                  95      


Glu Asp Glu Glu Glu Asp Asp Glu Glu Glu Glu Asp Glu Ser Ser Ser 
            100                 105                 110         


Ser Gly Gly Gly Glu Glu Glu Ser Ser Ala Glu Ser Leu Val Gly Ser 
        115                 120                 125             


Ser Gly Gly Ser Ser Ser Asp Glu Xaa Arg Ser Leu Ser Pro Gly Ala 
    130                 135                 140                 


Ala Ser Ser Ser Ser Gly Asp Gly Asp Gly Lys Glu Gly Leu Glu Glu 
145                 150                 155                 160 


Pro Lys Gly Pro Arg Gly Ser Gln Gly Gly Gly Gly Gly Gly Ser Ser 
                165                 170                 175     


Ser Ser Ser Val Val Ser Ser Gly Gly Asp Glu Gly Tyr Gly Xaa Gly 
            180                 185                 190         


Gly Gly Gly Ser Ser Ala Xaa Ser Gly Gly Arg Arg Gly Ser Leu Glu 
        195                 200                 205             


Met Ser Ser Asp Gly Glu Pro Leu Ser Arg Met Asp Ser Glu Asp Ser 
    210                 215                 220                 


Ile Ser Ser Xaa Ile Met Asp Val Asp Ser Xaa Ile Ser Ser Gly Arg 
225                 230                 235                 240 


Ser Xaa Pro Ala Met Met Asn Gly Gln Gly Ser Xaa Xaa Ser Ser Ser 
                245                 250                 255     


Lys Asn Ile Ala Tyr Asn Cys Cys Trp Asp Gln Cys Gln Ala Cys Phe 
            260                 265                 270         


Asn Ser Ser Pro Asp Leu Ala Asp His Ile Arg Ser Ile His Val Asp 
        275                 280                 285             


Gly Gln Arg Gly Gly Val Phe Val Cys Leu Trp Lys Gly Cys Lys Val 
    290                 295                 300                 


Tyr Asn Xaa Pro Ser Xaa Ser Gln Ser Trp Leu Gln Arg His Met Leu 
305                 310                 315                 320 


Xaa His Ser Gly Asp Lys Pro Phe Lys Cys Val Val Gly Gly Cys Asn 
                325                 330                 335     


Ala Ser Phe Ala Ser Gln Gly Gly Leu Ala Arg His Val Pro Xaa His 
            340                 345                 350         


Phe Ser Gln Gln Asn Ser Ser Lys Val Ser Ser Gln Pro Lys Ala Lys 
        355                 360                 365             


Glu Glu Ser Pro Ser Lys Ala Gly Met Asn Lys Arg Arg Lys Leu Lys 
    370                 375                 380                 


Asn Lys Arg Arg Arg Ser Leu Pro Arg Pro His Asp Phe Phe Asp Ala 
385                 390                 395                 400 


Gln Xaa Leu Asp Ala Ile Arg His Arg Ala Ile Cys Phe Asn Leu Ser 
                405                 410                 415     


Ala His Ile Glu Ser Leu Gly Lys Gly His Ser Val Val Phe His Ser 
            420                 425                 430         


Xaa Val Ile Ala Lys Arg Lys Glu Asp Ser Gly Lys Ile Lys Leu Leu 
        435                 440                 445             


Leu His Trp Met Pro Glu Asp Ile Leu Pro Asp Val Trp Val Asn Glu 
    450                 455                 460                 


Ser Glu Arg His Gln Leu Lys Xaa Lys Val Val His Leu Ser Lys Leu 
465                 470                 475                 480 


Pro Lys Asp Xaa Ala Leu Leu Leu Asp Pro Asn Ile Tyr Arg Xaa Met 
                485                 490                 495     


Pro Gln Lys Arg Leu Lys Arg 
            500             


<210> 1860
<211> 517
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<400> 1860
Met Ala Ala Ala Ile Xaa Asp Met Ala Asp Leu Glu Glu Leu Ser Arg 
1               5                   10                  15      


Leu Ser Pro Leu Pro Pro Gly Ser Pro Gly Ser Ala Ala Arg Gly Arg 
            20                  25                  30          


Ala Glu Pro Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        35                  40                  45              


Ala Glu Ala Glu Ala Val Ala Ala Leu Leu Leu Asn Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Val Gly Gly Gly Glu Ala Glu 
65                  70                  75                  80  


Xaa Met Ser Glu Pro Ser Pro Glu Ser Ala Ser Gln Ala Gly Glu Asp 
                85                  90                  95      


Glu Asp Glu Glu Glu Asp Asp Glu Glu Glu Glu Asp Glu Ser Ser Ser 
            100                 105                 110         


Ser Gly Gly Gly Glu Glu Glu Ser Ser Ala Glu Ser Leu Val Gly Ser 
        115                 120                 125             


Ser Gly Gly Ser Ser Ser Asp Glu Xaa Arg Ser Leu Ser Pro Gly Ala 
    130                 135                 140                 


Ala Ser Ser Ser Ser Gly Asp Gly Asp Gly Lys Glu Gly Leu Glu Glu 
145                 150                 155                 160 


Pro Lys Gly Pro Arg Gly Ser Gln Gly Gly Gly Gly Gly Gly Ser Ser 
                165                 170                 175     


Ser Ser Ser Val Val Ser Ser Gly Gly Asp Glu Gly Tyr Gly Xaa Gly 
            180                 185                 190         


Gly Gly Gly Ser Ser Ala Xaa Ser Gly Gly Arg Arg Gly Ser Leu Glu 
        195                 200                 205             


Met Ser Ser Asp Gly Glu Pro Leu Ser Arg Met Asp Ser Glu Asp Ser 
    210                 215                 220                 


Ile Ser Ser Xaa Ile Met Asp Val Asp Ser Xaa Ile Ser Ser Gly Arg 
225                 230                 235                 240 


Ser Xaa Pro Ala Met Met Asn Gly Gln Gly Ser Xaa Xaa Ser Ser Ser 
                245                 250                 255     


Lys Asn Ile Ala Tyr Asn Cys Cys Trp Asp Gln Cys Gln Ala Cys Phe 
            260                 265                 270         


Asn Ser Ser Pro Asp Leu Ala Asp His Ile Arg Ser Ile His Val Asp 
        275                 280                 285             


Gly Gln Arg Gly Gly Val Phe Val Cys Leu Trp Lys Gly Cys Lys Val 
    290                 295                 300                 


Tyr Asn Xaa Pro Ser Xaa Ser Gln Ser Trp Leu Gln Arg His Met Leu 
305                 310                 315                 320 


Xaa His Ser Gly Asp Lys Pro Phe Lys Cys Val Val Gly Gly Cys Asn 
                325                 330                 335     


Ala Ser Phe Ala Ser Gln Gly Gly Leu Ala Arg His Val Pro Xaa His 
            340                 345                 350         


Phe Ser Gln Gln Asn Ser Ser Lys Val Ser Ser Gln Pro Lys Ala Lys 
        355                 360                 365             


Glu Glu Ser Pro Ser Lys Ala Gly Met Asn Lys Arg Arg Lys Leu Lys 
    370                 375                 380                 


Asn Lys Arg Arg Arg Ser Leu Pro Arg Pro His Asp Phe Phe Asp Ala 
385                 390                 395                 400 


Gln Xaa Leu Asp Ala Ile Arg His Arg Ala Ile Cys Phe Asn Leu Ser 
                405                 410                 415     


Ala His Ile Glu Ser Leu Gly Lys Gly His Ser Val Val Phe His Ser 
            420                 425                 430         


Xaa Val Ile Ala Lys Arg Lys Glu Asp Ser Gly Lys Ile Lys Leu Leu 
        435                 440                 445             


Leu His Trp Met Pro Glu Asp Ile Leu Pro Asp Val Trp Val Asn Glu 
    450                 455                 460                 


Ser Glu Arg His Gln Leu Lys Xaa Lys Val Val His Leu Ser Lys Leu 
465                 470                 475                 480 


Pro Lys Asp Xaa Ala Leu Leu Leu Asp Pro Asn Ile Tyr Arg Xaa Met 
                485                 490                 495     


Pro Gln Lys Arg Leu Lys Arg Xaa Leu Ile Arg Lys Val Phe Asn Leu 
            500                 505                 510         


Tyr Leu Ser Lys Gln 
        515         


<210> 1861
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 1861
Met Asp Val Asp Ser Xaa Ile Ser Ser Gly Arg Ser Xaa Pro Ala Met 
1               5                   10                  15      


Met Asn Gly Gln Gly Ser Xaa Xaa Ser Ser Ser Lys Asn Ile Ala Tyr 
            20                  25                  30          


Asn Cys Cys Trp Asp Gln Cys Gln Ala Cys Phe Asn Ser Ser Pro Asp 
        35                  40                  45              


Leu Ala Asp His Ile Arg Ser Ile His Val Asp Gly Gln Arg Gly Gly 
    50                  55                  60                  


Val Phe Val Cys Leu Trp Lys Gly Cys Lys Val Tyr Asn Xaa Pro Ser 
65                  70                  75                  80  


Xaa Ser Gln Ser Trp Leu Gln Arg His Met Leu Xaa His Ser Gly Asp 
                85                  90                  95      


Lys Pro Phe Lys Cys Val Val Gly Gly Cys Asn Ala Ser Phe 
            100                 105                 110 


<210> 1862
<211> 274
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<400> 1862
Met Asp Val Asp Ser Xaa Ile Ser Ser Gly Arg Ser Xaa Pro Ala Met 
1               5                   10                  15      


Met Asn Gly Gln Gly Ser Xaa Xaa Ser Ser Ser Lys Asn Ile Ala Tyr 
            20                  25                  30          


Asn Cys Cys Trp Asp Gln Cys Gln Ala Cys Phe Asn Ser Ser Pro Asp 
        35                  40                  45              


Leu Ala Asp His Ile Arg Ser Ile His Val Asp Gly Gln Arg Gly Gly 
    50                  55                  60                  


Val Phe Val Cys Leu Trp Lys Gly Cys Lys Val Tyr Asn Xaa Pro Ser 
65                  70                  75                  80  


Xaa Ser Gln Ser Trp Leu Gln Arg His Met Leu Xaa His Ser Gly Asp 
                85                  90                  95      


Lys Pro Phe Lys Cys Val Val Gly Gly Cys Asn Ala Ser Phe Ala Ser 
            100                 105                 110         


Gln Gly Gly Leu Ala Arg His Val Pro Xaa His Phe Ser Gln Gln Asn 
        115                 120                 125             


Ser Ser Lys Val Ser Ser Gln Pro Lys Ala Lys Glu Glu Ser Pro Ser 
    130                 135                 140                 


Lys Ala Gly Met Asn Lys Arg Arg Lys Leu Lys Asn Lys Arg Arg Arg 
145                 150                 155                 160 


Ser Leu Pro Arg Pro His Asp Phe Phe Asp Ala Gln Xaa Leu Asp Ala 
                165                 170                 175     


Ile Arg His Arg Ala Ile Cys Phe Asn Leu Ser Ala His Ile Glu Ser 
            180                 185                 190         


Leu Gly Lys Gly His Ser Val Val Phe His Ser Xaa Val Ile Ala Lys 
        195                 200                 205             


Arg Lys Glu Asp Ser Gly Lys Ile Lys Leu Leu Leu His Trp Met Pro 
    210                 215                 220                 


Glu Asp Ile Leu Pro Asp Val Trp Val Asn Glu Ser Glu Arg His Gln 
225                 230                 235                 240 


Leu Lys Xaa Lys Val Val His Leu Ser Lys Leu Pro Lys Asp Xaa Ala 
                245                 250                 255     


Leu Leu Leu Asp Pro Asn Ile Tyr Arg Xaa Met Pro Gln Lys Arg Leu 
            260                 265                 270         


Lys Arg 
        


<210> 1863
<211> 301
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<400> 1863
Met Tyr Xaa Arg Arg Tyr Ser Ser Ile Ser Ser Xaa Ile Met Asp Val 
1               5                   10                  15      


Asp Ser Xaa Ile Ser Ser Gly Arg Ser Xaa Pro Ala Met Met Asn Gly 
            20                  25                  30          


Gln Gly Ser Xaa Xaa Ser Ser Ser Lys Asn Ile Ala Tyr Asn Cys Cys 
        35                  40                  45              


Trp Asp Gln Cys Gln Ala Cys Phe Asn Ser Ser Pro Asp Leu Ala Asp 
    50                  55                  60                  


His Ile Arg Ser Ile His Val Asp Gly Gln Arg Gly Gly Val Phe Val 
65                  70                  75                  80  


Cys Leu Trp Lys Gly Cys Lys Val Tyr Asn Xaa Pro Ser Xaa Ser Gln 
                85                  90                  95      


Ser Trp Leu Gln Arg His Met Leu Xaa His Ser Gly Asp Lys Pro Phe 
            100                 105                 110         


Lys Cys Val Val Gly Gly Cys Asn Ala Ser Phe Ala Ser Gln Gly Gly 
        115                 120                 125             


Leu Ala Arg His Val Pro Xaa His Phe Ser Gln Gln Asn Ser Ser Lys 
    130                 135                 140                 


Val Ser Ser Gln Pro Lys Ala Lys Glu Glu Ser Pro Ser Lys Ala Gly 
145                 150                 155                 160 


Met Asn Lys Arg Arg Lys Leu Lys Asn Lys Arg Arg Arg Ser Leu Pro 
                165                 170                 175     


Arg Pro His Asp Phe Phe Asp Ala Gln Xaa Leu Asp Ala Ile Arg His 
            180                 185                 190         


Arg Ala Ile Cys Phe Asn Leu Ser Ala His Ile Glu Ser Leu Gly Lys 
        195                 200                 205             


Gly His Ser Val Val Phe His Ser Xaa Val Ile Ala Lys Arg Lys Glu 
    210                 215                 220                 


Asp Ser Gly Lys Ile Lys Leu Leu Leu His Trp Met Pro Glu Asp Ile 
225                 230                 235                 240 


Leu Pro Asp Val Trp Val Asn Glu Ser Glu Arg His Gln Leu Lys Xaa 
                245                 250                 255     


Lys Val Val His Leu Ser Lys Leu Pro Lys Asp Xaa Ala Leu Leu Leu 
            260                 265                 270         


Asp Pro Asn Ile Tyr Arg Xaa Met Pro Gln Lys Arg Leu Lys Arg Xaa 
        275                 280                 285             


Leu Ile Arg Lys Val Phe Asn Leu Tyr Leu Ser Lys Gln 
    290                 295                 300     


<210> 1864
<211> 179
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<400> 1864
Met Val Pro Arg Glu Ala Pro Glu Ser Ala Gln Cys Leu Cys Pro Ser 
1               5                   10                  15      


Leu Xaa Ile Pro Asn Ala Lys Asp Val Leu Arg Lys Arg His Lys Arg 
            20                  25                  30          


Arg Ser Arg Gln His Gln Arg Phe Met Ala Arg Lys Ala Leu Leu Gln 
        35                  40                  45              


Glu Gln Gly Leu Leu Ser Met Pro Pro Glu Pro Gly Ser Ser Pro Leu 
    50                  55                  60                  


Pro Xaa Pro Phe Gly Ala Ala Xaa Ala Xaa Glu Ala Ala Ser Ser Gly 
65                  70                  75                  80  


Lys Gln Cys Leu Arg Ala Gly Ser Gly Ser Ala Pro Cys Ser Arg Arg 
                85                  90                  95      


Pro Ala Pro Gly Lys Ala Ser Gly Pro Leu Pro Ser Lys Cys Val Ala 
            100                 105                 110         


Ile Asp Cys Glu Met Val Gly Xaa Gly Pro Arg Gly Arg Val Ser Glu 
        115                 120                 125             


Leu Ala Arg Cys Ser Ile Val Ser Tyr His Gly Asn Val Leu Tyr Asp 
    130                 135                 140                 


Lys Tyr Ile Arg Pro Glu Met Pro Ile Ala Asp Tyr Arg Xaa Arg Trp 
145                 150                 155                 160 


Ser Gly Ile Xaa Arg Gln His Met Arg Lys Ala Val Pro Phe Gln Val 
                165                 170                 175     


Ala Gln Lys 
            


<210> 1865
<211> 325
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<400> 1865
Met Val Pro Arg Glu Ala Pro Glu Ser Ala Gln Cys Leu Cys Pro Ser 
1               5                   10                  15      


Leu Xaa Ile Pro Asn Ala Lys Asp Val Leu Arg Lys Arg His Lys Arg 
            20                  25                  30          


Arg Ser Arg Gln His Gln Arg Phe Met Ala Arg Lys Ala Leu Leu Gln 
        35                  40                  45              


Glu Gln Gly Leu Leu Ser Met Pro Pro Glu Pro Gly Ser Ser Pro Leu 
    50                  55                  60                  


Pro Xaa Pro Phe Gly Ala Ala Xaa Ala Xaa Glu Ala Ala Ser Ser Gly 
65                  70                  75                  80  


Lys Gln Cys Leu Arg Ala Gly Ser Gly Ser Ala Pro Cys Ser Arg Arg 
                85                  90                  95      


Pro Ala Pro Gly Lys Ala Ser Gly Pro Leu Pro Ser Lys Cys Val Ala 
            100                 105                 110         


Ile Asp Cys Glu Met Val Gly Xaa Gly Pro Arg Gly Arg Val Ser Glu 
        115                 120                 125             


Leu Ala Arg Cys Ser Ile Val Ser Tyr His Gly Asn Val Leu Tyr Asp 
    130                 135                 140                 


Lys Tyr Ile Arg Pro Glu Met Pro Ile Ala Asp Tyr Arg Xaa Arg Trp 
145                 150                 155                 160 


Ser Gly Ile Xaa Arg Gln His Met Arg Lys Ala Val Pro Phe Gln Val 
                165                 170                 175     


Ala Gln Lys Glu Ile Leu Lys Leu Leu Lys Gly Lys Val Val Val Gly 
            180                 185                 190         


His Ala Leu His Asn Asp Phe Gln Ala Leu Lys Tyr Val His Pro Arg 
        195                 200                 205             


Ser Gln Xaa Arg Asp Xaa Xaa Tyr Val Pro Asn Phe Leu Ser Glu Pro 
    210                 215                 220                 


Gly Leu His Xaa Arg Ala Arg Val Ser Leu Lys Asp Leu Ala Leu Gln 
225                 230                 235                 240 


Leu Leu His Lys Lys Ile Gln Val Gly Gln His Gly His Ser Ser Val 
                245                 250                 255     


Glu Asp Ala Xaa Xaa Ala Met Glu Leu Tyr Arg Leu Val Glu Val Gln 
            260                 265                 270         


Trp Glu Gln Gln Glu Ala Arg Ser Leu Trp Xaa Cys Pro Glu Asp Arg 
        275                 280                 285             


Glu Pro Asp Ser Ser Xaa Asp Met Glu Gln Tyr Met Glu Asp Gln Tyr 
    290                 295                 300                 


Trp Pro Asp Asp Leu Ala His Gly Ser Arg Gly Gly Ala Arg Glu Ala 
305                 310                 315                 320 


Gln Asp Arg Arg Asn 
                325 


<210> 1866
<211> 264
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<400> 1866
Met Cys His Lys Asn Gly Phe Pro Gln Glu Gly Gly Ile Xaa Ala Ala 
1               5                   10                  15      


Phe Leu Gln Lys Arg Lys Leu Arg Leu Ser Lys Asn His Arg Pro Ala 
            20                  25                  30          


Arg Ala Lys Val Xaa Glu His Val Arg Gly Xaa Arg Pro Gly Arg Ala 
        35                  40                  45              


Xaa Ala Gly Pro Ala Ala Ser Xaa Arg Ala Ala Gly Ser Leu Phe Phe 
    50                  55                  60                  


Asp Arg Trp Gly Asn Arg Gly Pro Ala Gly Cys Arg Gly Ser Ser His 
65                  70                  75                  80  


Leu Pro Gln Gln Leu Lys Phe Xaa Xaa Ser Asp Ser Cys Asp Arg Ile 
                85                  90                  95      


Lys Asp Glu Phe Gln Leu Leu Gln Ala Gln Tyr His Ser Leu Lys Leu 
            100                 105                 110         


Glu Cys Asp Lys Leu Ala Ser Glu Lys Ser Glu Met Gln Arg His Tyr 
        115                 120                 125             


Val Met Tyr Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu Met His Lys 
    130                 135                 140                 


Gln Ala Glu Ile Val Lys Arg Leu Asn Gly Ile Cys Ala Gln Val Leu 
145                 150                 155                 160 


Pro Tyr Leu Ser Gln Glu His Gln Gln Gln Val Leu Gly Ala Ile Glu 
                165                 170                 175     


Arg Ala Lys Gln Val Xaa Ala Pro Glu Leu Asn Ser Ile Ile Arg Gln 
            180                 185                 190         


Gln Leu Gln Ala His Gln Leu Ser Gln Leu Gln Ala Leu Ala Leu Pro 
        195                 200                 205             


Leu Xaa Pro Leu Pro Val Gly Leu Gln Pro Pro Ser Leu Pro Ala Val 
    210                 215                 220                 


Ser Ala Gly Xaa Gly Leu Leu Ser Leu Ser Ala Leu Gly Ser Gln Ala 
225                 230                 235                 240 


His Leu Ser Lys Glu Asp Lys Asn Gly His Asp Gly Asp Xaa His Gln 
                245                 250                 255     


Glu Asp Asp Gly Glu Lys Ser Asp 
            260                 


<210> 1867
<211> 48
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(22)
<223> Selenocysteine

<400> 1867
Met Met Phe Pro Gln Ser Arg His Ser Gly Ser Ser His Leu Pro Gln 
1               5                   10                  15      


Gln Leu Lys Phe Xaa Xaa Ser Asp Ser Cys Asp Arg Ile Lys Asp Glu 
            20                  25                  30          


Phe Gln Leu Leu Gln Ala Gln Tyr His Arg Leu Arg Ser Ser Lys Gly 
        35                  40                  45              


<210> 1868
<211> 197
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<400> 1868
Met Met Phe Pro Gln Ser Arg His Ser Gly Ser Ser His Leu Pro Gln 
1               5                   10                  15      


Gln Leu Lys Phe Xaa Xaa Ser Asp Ser Cys Asp Arg Ile Lys Asp Glu 
            20                  25                  30          


Phe Gln Leu Leu Gln Ala Gln Tyr His Ser Leu Lys Leu Glu Cys Asp 
        35                  40                  45              


Lys Leu Ala Ser Glu Lys Ser Glu Met Gln Arg His Tyr Val Met Tyr 
    50                  55                  60                  


Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu Met His Lys Gln Ala Glu 
65                  70                  75                  80  


Ile Val Lys Arg Leu Asn Gly Ile Cys Ala Gln Val Leu Pro Tyr Leu 
                85                  90                  95      


Ser Gln Glu His Gln Gln Gln Val Leu Gly Ala Ile Glu Arg Ala Lys 
            100                 105                 110         


Gln Val Xaa Ala Pro Glu Leu Asn Ser Ile Ile Arg Gln Gln Leu Gln 
        115                 120                 125             


Ala His Gln Leu Ser Gln Leu Gln Ala Leu Ala Leu Pro Leu Xaa Pro 
    130                 135                 140                 


Leu Pro Val Gly Leu Gln Pro Pro Ser Leu Pro Ala Val Ser Ala Gly 
145                 150                 155                 160 


Xaa Gly Leu Leu Ser Leu Ser Ala Leu Gly Ser Gln Ala His Leu Ser 
                165                 170                 175     


Lys Glu Asp Lys Asn Gly His Asp Gly Asp Xaa His Gln Glu Asp Asp 
            180                 185                 190         


Gly Glu Lys Ser Asp 
        195         


<210> 1869
<211> 141
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<400> 1869
Met Gln Arg His Tyr Val Met Tyr Tyr Glu Met Ser Tyr Gly Leu Asn 
1               5                   10                  15      


Ile Glu Met His Lys Gln Ala Glu Ile Val Lys Arg Leu Asn Gly Ile 
            20                  25                  30          


Cys Ala Gln Val Leu Pro Tyr Leu Ser Gln Glu His Gln Gln Gln Val 
        35                  40                  45              


Leu Gly Ala Ile Glu Arg Ala Lys Gln Val Xaa Ala Pro Glu Leu Asn 
    50                  55                  60                  


Ser Ile Ile Arg Gln Gln Leu Gln Ala His Gln Leu Ser Gln Leu Gln 
65                  70                  75                  80  


Ala Leu Ala Leu Pro Leu Xaa Pro Leu Pro Val Gly Leu Gln Pro Pro 
                85                  90                  95      


Ser Leu Pro Ala Val Ser Ala Gly Xaa Gly Leu Leu Ser Leu Ser Ala 
            100                 105                 110         


Leu Gly Ser Gln Ala His Leu Ser Lys Glu Asp Lys Asn Gly His Asp 
        115                 120                 125             


Gly Asp Xaa His Gln Glu Asp Asp Gly Glu Lys Ser Asp 
    130                 135                 140     


<210> 1870
<211> 264
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(225)
<223> Selenocysteine

<400> 1870
Xaa Ala Phe Leu Gln Lys Arg Lys Leu Arg Leu Ser Lys Asn His Arg 
1               5                   10                  15      


Pro Ala Arg Ala Lys Val Xaa Glu His Val Arg Gly Xaa Arg Pro Gly 
            20                  25                  30          


Arg Ala Xaa Ala Gly Pro Ala Ala Ser Xaa Arg Ala Ala Gly Ser Leu 
        35                  40                  45              


Phe Phe Asp Arg Trp Gly Asn Arg Gly Pro Ala Gly Cys Arg Gly Ser 
    50                  55                  60                  


Ser His Leu Pro Gln Gln Leu Lys Phe Xaa Xaa Ser Asp Ser Cys Asp 
65                  70                  75                  80  


Arg Ile Lys Asp Glu Phe Gln Leu Leu Gln Ala Gln Tyr His Ser Leu 
                85                  90                  95      


Lys Leu Glu Cys Asp Lys Leu Ala Ser Glu Lys Ser Glu Met Gln Arg 
            100                 105                 110         


His Tyr Val Met Tyr Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu Met 
        115                 120                 125             


His Lys Gln Ala Glu Ile Val Lys Arg Leu Asn Gly Ile Cys Ala Gln 
    130                 135                 140                 


Val Leu Pro Tyr Leu Ser Gln Glu His Gln Gln Gln Val Leu Gly Ala 
145                 150                 155                 160 


Ile Glu Arg Ala Lys Gln Val Xaa Ala Pro Glu Leu Asn Ser Ile Ile 
                165                 170                 175     


Arg Val Cys Met Gly Xaa Trp Ala Gly Gly Arg Gly Xaa Gly Gly Pro 
            180                 185                 190         


Gln Ala Ala Asn Val Pro Leu Pro Arg Pro Ala Ala Ala Ala Pro Ser 
        195                 200                 205             


Pro Pro Ala Val Pro Ala Ala Gly Pro Gly Pro Ala Leu Asp Pro Xaa 
    210                 215                 220                 


Xaa Arg Gly Ala Ala Ala Ala Phe Ala Ala Gly Gly Gln Arg Arg His 
225                 230                 235                 240 


Arg Pro Pro Leu Ala Val Arg Ala Gly Phe Pro Gly Pro Pro Leu Gln 
                245                 250                 255     


Gly Arg Gln Glu Arg Ala Arg Trp 
            260                 


<210> 1871
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<400> 1871
Gly Ile Xaa Xaa Cys Asn Gly Lys Glu Gln Val Lys Arg Lys Lys Ser 
1               5                   10                  15      


Ser Lys Ser Glu Ala Lys Gly Xaa Val Ser Lys Val Xaa Gly Lys Lys 
            20                  25                  30          


Ile Xaa Lys Ile Ile Ser Leu Gly Lys Lys Lys Pro Ser Xaa Asp Glu 
        35                  40                  45              


Gln Xaa Ser Ser Ala Glu Glu Asp Val Pro Xaa Cys Gly Lys Xaa Ala 
    50                  55                  60                  


Leu Pro Gly Asp Glu Gln Arg Ala Pro Lys Trp Val Ser Phe Ser Pro 
65                  70                  75                  80  


Ala Val Val Ser Val Pro Ser Ser Ser Lys Ala Arg 
                85                  90          


<210> 1872
<211> 730
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<400> 1872
Met Glu Glu Leu Ile Val Glu Leu Arg Leu Phe Leu Glu Leu Leu Asp 
1               5                   10                  15      


His Glu Tyr Leu Xaa Ser Xaa Val Arg Glu Lys Lys Ala Val Ile Xaa 
            20                  25                  30          


Asn Ile Leu Leu Arg Ile Gln Ser Ser Lys Gly Phe Asp Val Lys Asp 
        35                  40                  45              


His Ala Gln Lys Gln Glu Xaa Ala Asn Ser Leu Pro Ala Pro Pro Gln 
    50                  55                  60                  


Met Pro Leu Pro Glu Ile Pro Gln Pro Trp Leu Pro Pro Asp Ser Gly 
65                  70                  75                  80  


Pro Pro Pro Leu Pro Xaa Ser Ser Leu Pro Glu Gly Tyr Tyr Glu Glu 
                85                  90                  95      


Ala Val Pro Leu Ser Pro Gly Lys Ala Pro Glu Tyr Ile Xaa Ser Asn 
            100                 105                 110         


Tyr Asp Ser Asp Ala Met Ser Ser Ser Tyr Glu Ser Tyr Asp Glu Glu 
        115                 120                 125             


Glu Glu Asp Gly Lys Gly Lys Lys Xaa Arg His Gln Trp Pro Ser Glu 
    130                 135                 140                 


Glu Ala Ser Met Asp Leu Val Lys Asp Ala Lys Ile Cys Ala Phe Leu 
145                 150                 155                 160 


Leu Arg Lys Lys Arg Phe Gly Gln Trp Xaa Lys Leu Leu Cys Val Ile 
                165                 170                 175     


Lys Asp Xaa Lys Leu Leu Cys Tyr Lys Ser Ser Lys Asp Gln Gln Pro 
            180                 185                 190         


Gln Met Glu Leu Pro Leu Gln Gly Cys Asn Ile Xaa Tyr Ile Pro Lys 
        195                 200                 205             


Asp Ser Lys Lys Lys Lys His Glu Leu Lys Ile Xaa Gln Gln Gly Xaa 
    210                 215                 220                 


Asp Pro Leu Val Leu Ala Val Gln Ser Lys Glu Gln Ala Glu Gln Trp 
225                 230                 235                 240 


Leu Lys Val Ile Lys Glu Ala Tyr Ser Gly Cys Ser Gly Pro Val Asp 
                245                 250                 255     


Ser Glu Cys Pro Pro Pro Pro Ser Ser Pro Val His Lys Ala Glu Leu 
            260                 265                 270         


Glu Lys Lys Leu Ser Ser Glu Arg Pro Ser Ser Asp Gly Glu Gly Val 
        275                 280                 285             


Val Glu Asn Gly Ile Xaa Xaa Cys Asn Gly Lys Glu Gln Val Lys Arg 
    290                 295                 300                 


Lys Lys Ser Ser Lys Ser Glu Ala Lys Gly Xaa Val Ser Lys Val Xaa 
305                 310                 315                 320 


Gly Lys Lys Ile Xaa Lys Ile Ile Ser Leu Gly Lys Lys Lys Pro Ser 
                325                 330                 335     


Xaa Asp Glu Gln Xaa Ser Ser Ala Glu Glu Asp Val Pro Xaa Cys Gly 
            340                 345                 350         


Tyr Leu Asn Val Leu Ser Asn Ser Arg Trp Arg Glu Arg Trp Cys Arg 
        355                 360                 365             


Val Lys Asp Asn Lys Leu Ile Phe His Lys Asp Arg Xaa Asp Leu Lys 
    370                 375                 380                 


Xaa His Ile Val Ser Ile Pro Leu Arg Gly Cys Glu Val Ile Pro Gly 
385                 390                 395                 400 


Leu Asp Ser Lys His Pro Leu Xaa Phe Arg Leu Leu Arg Asn Gly Gln 
                405                 410                 415     


Glu Val Ala Val Leu Glu Ala Ser Ser Ser Glu Asp Met Gly Arg Trp 
            420                 425                 430         


Ile Gly Ile Leu Leu Ala Glu Xaa Gly Ser Ser Xaa Asp Pro Glu Ala 
        435                 440                 445             


Leu His Tyr Asp Tyr Ile Asp Val Glu Met Ser Ala Ser Val Ile Gln 
    450                 455                 460                 


Xaa Ala Lys Gln Xaa Phe Cys Phe Met Asn Arg Arg Val Ile Ser Ala 
465                 470                 475                 480 


Asn Pro Tyr Leu Gly Gly Xaa Ser Asn Gly Tyr Ala His Pro Ser Gly 
                485                 490                 495     


Xaa Ala Leu His Tyr Asp Asp Val Pro Cys Ile Asn Gly Ser Leu Lys 
            500                 505                 510         


Gly Lys Lys Pro Pro Val Ala Ser Asn Gly Val Xaa Gly Lys Gly Lys 
        515                 520                 525             


Xaa Leu Ser Ser Gln Pro Lys Lys Ala Asp Pro Ala Ala Val Val Lys 
    530                 535                 540                 


Arg Xaa Gly Ser Asn Ala Ala Gln Tyr Lys Tyr Gly Lys Asn Arg Val 
545                 550                 555                 560 


Glu Ala Asp Ala Lys Arg Leu Gln Xaa Lys Glu Glu Glu Leu Leu Lys 
                565                 570                 575     


Arg Lys Glu Ala Leu Arg Asn Arg Leu Ala Gln Leu Arg Lys Glu Arg 
            580                 585                 590         


Lys Asp Leu Arg Ala Ala Ile Glu Val Asn Ala Gly Arg Lys Pro Gln 
        595                 600                 605             


Ala Ile Leu Glu Glu Lys Leu Lys Gln Leu Glu Glu Glu Cys Arg Gln 
    610                 615                 620                 


Lys Glu Ala Glu Arg Val Ser Leu Glu Leu Glu Leu Xaa Glu Val Lys 
625                 630                 635                 640 


Glu Ser Leu Lys Lys Ala Leu Ala Gly Gly Val Xaa Leu Gly Leu Ala 
                645                 650                 655     


Ile Glu Pro Lys Ser Gly Xaa Ser Ser Pro Gln Ser Pro Val Phe Arg 
            660                 665                 670         


His Arg Xaa Leu Glu Asn Ser Pro Ile Ser Ser Cys Asp Xaa Ser Asp 
        675                 680                 685             


Xaa Glu Gly Pro Val Pro Val Asn Ser Ala Ala Val Leu Lys Lys Ser 
    690                 695                 700                 


Gln Ala Ala Pro Gly Ser Ser Pro Cys Arg Gly His Val Leu Arg Lys 
705                 710                 715                 720 


Ala Lys Glu Trp Glu Leu Lys Asn Gly Xaa 
                725                 730 


<210> 1873
<211> 814
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<400> 1873
Met Glu Glu Leu Ile Val Glu Leu Arg Leu Phe Leu Glu Leu Leu Asp 
1               5                   10                  15      


His Glu Tyr Leu Xaa Ser Xaa Val Arg Glu Lys Lys Ala Val Ile Xaa 
            20                  25                  30          


Asn Ile Leu Leu Arg Ile Gln Ser Ser Lys Gly Phe Asp Val Lys Asp 
        35                  40                  45              


His Ala Gln Lys Gln Glu Xaa Ala Asn Ser Leu Pro Ala Pro Pro Gln 
    50                  55                  60                  


Met Pro Leu Pro Glu Ile Pro Gln Pro Trp Leu Pro Pro Asp Ser Gly 
65                  70                  75                  80  


Pro Pro Pro Leu Pro Xaa Ser Ser Leu Pro Glu Gly Tyr Tyr Glu Glu 
                85                  90                  95      


Ala Val Pro Leu Ser Pro Gly Lys Ala Pro Glu Tyr Ile Xaa Ser Asn 
            100                 105                 110         


Tyr Asp Ser Asp Ala Met Ser Ser Ser Tyr Glu Ser Tyr Asp Glu Glu 
        115                 120                 125             


Glu Glu Asp Gly Lys Gly Lys Lys Xaa Arg His Gln Trp Pro Ser Glu 
    130                 135                 140                 


Glu Ala Ser Met Asp Leu Val Lys Asp Ala Lys Ile Cys Ala Phe Leu 
145                 150                 155                 160 


Leu Arg Lys Lys Arg Phe Gly Gln Trp Xaa Lys Leu Leu Cys Val Ile 
                165                 170                 175     


Lys Asp Xaa Lys Leu Leu Cys Tyr Lys Ser Ser Lys Asp Gln Gln Pro 
            180                 185                 190         


Gln Met Glu Leu Pro Leu Gln Gly Cys Asn Ile Xaa Tyr Ile Pro Lys 
        195                 200                 205             


Asp Ser Lys Lys Lys Lys His Glu Leu Lys Ile Xaa Gln Gln Gly Xaa 
    210                 215                 220                 


Asp Pro Leu Val Leu Ala Val Gln Ser Lys Glu Gln Ala Glu Gln Trp 
225                 230                 235                 240 


Leu Lys Val Ile Lys Glu Ala Tyr Ser Gly Cys Ser Gly Pro Val Asp 
                245                 250                 255     


Ser Glu Cys Pro Pro Pro Pro Ser Ser Pro Val His Lys Ala Glu Leu 
            260                 265                 270         


Glu Lys Lys Leu Ser Ser Glu Arg Pro Ser Ser Asp Gly Glu Gly Val 
        275                 280                 285             


Val Glu Asn Gly Ile Xaa Xaa Cys Asn Gly Lys Glu Gln Val Lys Arg 
    290                 295                 300                 


Lys Lys Ser Ser Lys Ser Glu Ala Lys Gly Xaa Val Ser Lys Val Xaa 
305                 310                 315                 320 


Gly Lys Lys Ile Xaa Lys Ile Ile Ser Leu Gly Lys Lys Lys Pro Ser 
                325                 330                 335     


Xaa Asp Glu Gln Xaa Ser Ser Ala Glu Glu Asp Val Pro Xaa Cys Gly 
            340                 345                 350         


Tyr Leu Asn Val Leu Ser Asn Ser Arg Trp Arg Glu Arg Trp Cys Arg 
        355                 360                 365             


Val Lys Asp Asn Lys Leu Ile Phe His Lys Asp Arg Xaa Asp Leu Lys 
    370                 375                 380                 


Xaa His Ile Val Ser Ile Pro Leu Arg Gly Cys Glu Val Ile Pro Gly 
385                 390                 395                 400 


Leu Asp Ser Lys His Pro Leu Xaa Phe Arg Leu Leu Arg Asn Gly Gln 
                405                 410                 415     


Glu Val Ala Val Leu Glu Ala Ser Ser Ser Glu Asp Met Gly Arg Trp 
            420                 425                 430         


Ile Gly Ile Leu Leu Ala Glu Xaa Gly Ser Ser Xaa Asp Pro Glu Ala 
        435                 440                 445             


Leu His Tyr Asp Tyr Ile Asp Val Glu Met Ser Ala Ser Val Ile Gln 
    450                 455                 460                 


Xaa Ala Lys Gln Xaa Phe Cys Phe Met Asn Arg Arg Val Ile Ser Ala 
465                 470                 475                 480 


Asn Pro Tyr Leu Gly Gly Xaa Ser Asn Gly Tyr Ala His Pro Ser Gly 
                485                 490                 495     


Xaa Ala Leu His Tyr Asp Asp Val Pro Cys Ile Asn Gly Ser Trp Glu 
            500                 505                 510         


Pro Glu Asp Gly Phe Pro Ala Ser Cys Ser Arg Gly Leu Gly Glu Glu 
        515                 520                 525             


Val Leu Tyr Asp Asn Ala Gly Leu Tyr Asp Asn Leu Pro Pro Pro His 
    530                 535                 540                 


Ile Phe Ala Arg Tyr Ser Pro Ala Asp Arg Lys Ala Ser Arg Leu Ser 
545                 550                 555                 560 


Ala Asp Lys Leu Ser Ser Asn His Tyr Lys Tyr Pro Ala Ser Ala Gln 
                565                 570                 575     


Ser Val Xaa Asn Xaa Ser Ser Val Gly Arg Ala Ser Leu Gly Leu Asn 
            580                 585                 590         


Ser Gln Leu Lys Gly Lys Lys Pro Pro Val Ala Ser Asn Gly Val Xaa 
        595                 600                 605             


Gly Lys Gly Lys Xaa Leu Ser Ser Gln Pro Lys Lys Ala Asp Pro Ala 
    610                 615                 620                 


Ala Val Val Lys Arg Xaa Gly Ser Asn Ala Ala Gln Tyr Lys Tyr Gly 
625                 630                 635                 640 


Lys Asn Arg Val Glu Ala Asp Ala Lys Arg Leu Gln Xaa Lys Glu Glu 
                645                 650                 655     


Glu Leu Leu Lys Arg Lys Glu Ala Leu Arg Asn Arg Leu Ala Gln Leu 
            660                 665                 670         


Arg Lys Glu Arg Lys Asp Leu Arg Ala Ala Ile Glu Val Asn Ala Gly 
        675                 680                 685             


Arg Lys Pro Gln Ala Ile Leu Glu Glu Lys Leu Lys Gln Leu Glu Glu 
    690                 695                 700                 


Glu Cys Arg Gln Lys Glu Ala Glu Arg Val Ser Leu Glu Leu Glu Leu 
705                 710                 715                 720 


Xaa Glu Val Lys Glu Ser Leu Lys Lys Ala Leu Ala Gly Gly Val Xaa 
                725                 730                 735     


Leu Gly Leu Ala Ile Glu Pro Lys Ser Gly Xaa Ser Ser Pro Gln Ser 
            740                 745                 750         


Pro Val Phe Arg His Arg Xaa Leu Glu Asn Ser Pro Ile Ser Ser Cys 
        755                 760                 765             


Asp Xaa Ser Asp Xaa Glu Gly Pro Val Pro Val Asn Ser Ala Ala Val 
    770                 775                 780                 


Leu Lys Lys Ser Gln Ala Ala Pro Gly Ser Ser Pro Cys Arg Gly His 
785                 790                 795                 800 


Val Leu Arg Lys Ala Lys Glu Trp Glu Leu Lys Asn Gly Xaa 
                805                 810                 


<210> 1874
<211> 814
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<400> 1874
Met Glu Arg Tyr Lys Ala Leu Glu Gln Leu Leu Xaa Glu Leu Asp Asp 
1               5                   10                  15      


Phe Leu Lys Ile Leu Asp Gln Glu Asn Leu Ser Ser Xaa Ala Leu Val 
            20                  25                  30          


Lys Lys Ser Cys Leu Ala Glu Leu Leu Arg Leu Tyr Xaa Lys Ser Ser 
        35                  40                  45              


Ser Ser Asp Glu Glu Tyr Ile Tyr Met Asn Lys Val Xaa Ile Asn Lys 
    50                  55                  60                  


Gln Gln Asn Ala Glu Ser Gln Gly Lys Ala Pro Glu Glu Gln Gly Leu 
65                  70                  75                  80  


Leu Pro Asn Gly Glu Pro Ser Gln His Ser Ser Ala Pro Gln Lys Ser 
                85                  90                  95      


Leu Pro Asp Leu Pro Pro Pro Lys Met Ile Pro Glu Arg Lys Gln Leu 
            100                 105                 110         


Ala Ile Pro Lys Xaa Glu Ser Pro Glu Gly Tyr Tyr Glu Glu Ala Glu 
        115                 120                 125             


Pro Tyr Asp Xaa Ser Leu Asn Glu Asp Gly Glu Ala Val Ser Ser Ser 
    130                 135                 140                 


Tyr Glu Ser Tyr Asp Glu Glu Asp Gly Ser Lys Gly Lys Ser Ala Pro 
145                 150                 155                 160 


Tyr Gln Trp Pro Ser Pro Glu Ala Gly Ile Glu Leu Met Arg Asp Ala 
                165                 170                 175     


Arg Ile Cys Ala Phe Leu Trp Arg Lys Lys Trp Leu Gly Gln Trp Ala 
            180                 185                 190         


Lys Gln Leu Cys Val Ile Lys Asp Asn Arg Leu Leu Cys Tyr Lys Ser 
        195                 200                 205             


Ser Lys Asp His Ser Pro Gln Leu Asp Val Asn Leu Leu Gly Ser Ser 
    210                 215                 220                 


Val Ile His Lys Glu Lys Gln Val Arg Lys Lys Glu His Lys Leu Lys 
225                 230                 235                 240 


Ile Xaa Pro Met Asn Ala Asp Val Ile Val Leu Gly Leu Gln Ser Lys 
                245                 250                 255     


Asp Gln Ala Glu Gln Trp Leu Arg Val Ile Gln Glu Val Ser Gly Leu 
            260                 265                 270         


Pro Ser Glu Gly Ala Ser Glu Gly Asn Gln Tyr Xaa Pro Asp Ala Gln 
        275                 280                 285             


Arg Phe Asn Cys Gln Lys Pro Asp Ile Ala Glu Lys Tyr Leu Ser Ala 
    290                 295                 300                 


Ser Glu Tyr Gly Ser Ser Val Asp Gly His Pro Glu Val Pro Glu Xaa 
305                 310                 315                 320 


Lys Asp Val Lys Lys Lys Cys Ser Ala Gly Leu Lys Leu Ser Asn Leu 
                325                 330                 335     


Met Asn Leu Gly Arg Lys Lys Ser Xaa Ser Leu Glu Pro Val Glu Arg 
            340                 345                 350         


Ser Leu Glu Xaa Ser Ser Tyr Leu Asn Val Leu Val Asn Ser Gln Trp 
        355                 360                 365             


Lys Ser Arg Trp Cys Ser Val Arg Asp Asn His Leu His Phe Tyr Gln 
    370                 375                 380                 


Asp Arg Asn Arg Ser Lys Val Ala Gln Gln Pro Leu Ser Leu Val Gly 
385                 390                 395                 400 


Cys Glu Val Val Pro Asp Pro Ser Pro Asp His Leu Tyr Ser Phe Arg 
                405                 410                 415     


Ile Leu His Lys Gly Glu Glu Leu Ala Lys Leu Glu Ala Lys Ser Ser 
            420                 425                 430         


Glu Glu Met Gly His Trp Leu Gly Leu Leu Leu Ser Glu Ser Gly Ser 
        435                 440                 445             


Lys Xaa Asp Pro Glu Glu Phe Xaa Tyr Asp Tyr Val Asp Ala Asp Arg 
    450                 455                 460                 


Val Ser Cys Ile Val Ser Ala Ala Lys Asn Ser Leu Leu Leu Met Gln 
465                 470                 475                 480 


Arg Lys Phe Ser Glu Pro Asn Xaa Tyr Ile Asp Gly Leu Pro Ser Gln 
                485                 490                 495     


Asp Arg Gln Glu Glu Leu Tyr Asp Asp Val Asp Leu Ser Glu Leu Xaa 
            500                 505                 510         


Ala Ala Val Glu Pro Xaa Glu Glu Ala Xaa Pro Val Ala Asp Asp Pro 
        515                 520                 525             


Asn Glu Arg Glu Ser Asp Arg Val Tyr Leu Asp Leu Xaa Pro Val Lys 
    530                 535                 540                 


Ser Phe Leu His Gly Pro Ser Ser Ala Gln Ala Gln Ala Ser Ser Pro 
545                 550                 555                 560 


Xaa Leu Ser Cys Leu Asp Asn Ala Xaa Glu Ala Leu Pro Ala Asp Ser 
                565                 570                 575     


Gly Pro Gly Pro Xaa Pro Asp Glu Pro Cys Ile Lys Cys Pro Glu Asn 
            580                 585                 590         


Leu Gly Glu Gln Gln Leu Glu Ser Leu Glu Pro Glu Asp Pro Ser Leu 
        595                 600                 605             


Arg Ile Xaa Xaa Val Lys Ile Gln Xaa Glu Gln Gln Arg Ile Ser Phe 
    610                 615                 620                 


Pro Pro Ser Cys Pro Asp Ala Val Val Ala Xaa Pro Pro Gly Ala Ser 
625                 630                 635                 640 


Pro Pro Val Lys Asp Arg Leu Arg Val Xaa Ser Ala Glu Ile Lys Leu 
                645                 650                 655     


Gly Lys Asn Arg Xaa Glu Ala Glu Val Lys Arg Tyr Xaa Glu Glu Lys 
            660                 665                 670         


Glu Arg Leu Glu Lys Lys Lys Glu Glu Ile Arg Gly His Leu Ala Gln 
        675                 680                 685             


Leu Arg Lys Glu Lys Arg Glu Leu Lys Glu Xaa Leu Leu Lys Cys Xaa 
    690                 695                 700                 


Asp Lys Glu Val Leu Ala Ser Leu Glu Gln Lys Leu Lys Glu Ile Asp 
705                 710                 715                 720 


Glu Glu Cys Arg Gly Glu Glu Ser Arg Arg Val Asp Leu Glu Leu Ser 
                725                 730                 735     


Ile Met Glu Val Lys Asp Asn Leu Lys Lys Ala Glu Ala Gly Pro Val 
            740                 745                 750         


Xaa Leu Gly Xaa Xaa Val Asp Xaa Xaa His Leu Glu Asn Pro Lys Ala 
        755                 760                 765             


Val Xaa Pro Ala Ser Ala Pro Asp Cys Xaa Pro Val Asn Ser Ala Xaa 
    770                 775                 780                 


Xaa Leu Lys Asn Arg Pro Leu Ser Val Val Val Xaa Gly Lys Gly Xaa 
785                 790                 795                 800 


Val Leu Gln Lys Ala Lys Glu Trp Glu Lys Lys Gly Ala Ser 
                805                 810                 


<210> 1875
<211> 818
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<400> 1875
Met Glu Arg Tyr Lys Ala Leu Glu Gln Leu Leu Xaa Glu Leu Asp Asp 
1               5                   10                  15      


Phe Leu Lys Ile Leu Asp Gln Glu Asn Leu Ser Ser Xaa Ala Leu Val 
            20                  25                  30          


Lys Lys Ser Cys Leu Ala Glu Leu Leu Arg Leu Tyr Xaa Lys Ser Ser 
        35                  40                  45              


Ser Ser Asp Glu Glu Tyr Ile Tyr Met Asn Lys Val Xaa Ile Asn Lys 
    50                  55                  60                  


Gln Gln Asn Ala Glu Ser Gln Gly Lys Ala Pro Glu Glu Gln Gly Leu 
65                  70                  75                  80  


Leu Pro Asn Gly Glu Pro Ser Gln His Ser Ser Ala Pro Gln Lys Ser 
                85                  90                  95      


Leu Pro Asp Leu Pro Pro Pro Lys Met Ile Pro Glu Arg Lys Gln Leu 
            100                 105                 110         


Ala Ile Pro Lys Xaa Glu Ser Pro Glu Gly Tyr Tyr Glu Glu Ala Glu 
        115                 120                 125             


Pro Tyr Asp Xaa Ser Leu Asn Glu Asp Gly Glu Ala Val Ser Ser Ser 
    130                 135                 140                 


Tyr Glu Ser Tyr Asp Glu Glu Asp Gly Ser Lys Gly Lys Ser Ala Pro 
145                 150                 155                 160 


Tyr Gln Trp Pro Ser Pro Glu Ala Gly Ile Glu Leu Met Arg Asp Ala 
                165                 170                 175     


Arg Ile Cys Ala Phe Leu Trp Arg Lys Lys Trp Leu Gly Gln Trp Ala 
            180                 185                 190         


Lys Gln Leu Cys Val Ile Lys Asp Asn Arg Leu Leu Cys Tyr Lys Ser 
        195                 200                 205             


Ser Lys Asp His Ser Pro Gln Leu Asp Val Asn Leu Leu Gly Ser Ser 
    210                 215                 220                 


Val Ile His Lys Glu Lys Gln Val Arg Lys Lys Glu His Lys Leu Lys 
225                 230                 235                 240 


Ile Xaa Pro Met Asn Ala Asp Val Ile Val Leu Gly Leu Gln Ser Lys 
                245                 250                 255     


Asp Gln Ala Glu Gln Trp Leu Arg Val Ile Gln Glu Val Ser Gly Leu 
            260                 265                 270         


Pro Ser Glu Gly Ala Ser Glu Gly Asn Gln Tyr Xaa Pro Asp Ala Gln 
        275                 280                 285             


Arg Phe Asn Cys Gln Lys Pro Asp Ile Ala Glu Lys Tyr Leu Ser Ala 
    290                 295                 300                 


Ser Glu Tyr Gly Ser Ser Val Asp Gly His Pro Glu Val Pro Glu Xaa 
305                 310                 315                 320 


Lys Asp Val Lys Lys Lys Cys Ser Ala Gly Leu Lys Leu Ser Asn Leu 
                325                 330                 335     


Met Asn Leu Gly Arg Lys Lys Ser Xaa Ser Leu Glu Pro Val Glu Arg 
            340                 345                 350         


Ser Leu Glu Xaa Ser Ser Tyr Leu Asn Val Leu Val Asn Ser Gln Trp 
        355                 360                 365             


Lys Ser Arg Trp Cys Ser Val Arg Asp Asn His Leu His Phe Tyr Gln 
    370                 375                 380                 


Asp Arg Asn Arg Ser Lys Val Ala Gln Gln Pro Leu Ser Leu Val Gly 
385                 390                 395                 400 


Cys Glu Val Val Pro Asp Pro Ser Pro Asp His Leu Tyr Ser Phe Arg 
                405                 410                 415     


Ile Leu His Lys Gly Glu Glu Leu Ala Lys Leu Glu Ala Lys Ser Ser 
            420                 425                 430         


Glu Glu Met Gly His Trp Leu Gly Leu Leu Leu Ser Glu Ser Gly Ser 
        435                 440                 445             


Lys Xaa Asp Pro Glu Glu Phe Xaa Tyr Asp Tyr Val Asp Ala Asp Arg 
    450                 455                 460                 


Val Ser Cys Ile Val Ser Ala Ala Lys Asn Ser Leu Leu Leu Met Gln 
465                 470                 475                 480 


Arg Lys Phe Ser Glu Pro Asn Xaa Tyr Ile Asp Gly Leu Pro Ser Gln 
                485                 490                 495     


Asp Arg Gln Glu Glu Leu Tyr Asp Asp Val Asp Leu Ser Glu Leu Xaa 
            500                 505                 510         


Ala Ala Val Glu Pro Xaa Glu Glu Ala Xaa Pro Val Ala Asp Asp Pro 
        515                 520                 525             


Asn Glu Arg Glu Ser Asp Arg Val Tyr Leu Asp Leu Xaa Pro Val Lys 
    530                 535                 540                 


Ser Phe Leu His Gly Pro Ser Ser Ala Gln Ala Gln Ala Ser Ser Pro 
545                 550                 555                 560 


Xaa Leu Ser Cys Leu Asp Asn Ala Xaa Glu Ala Leu Pro Ala Asp Ser 
                565                 570                 575     


Gly Pro Gly Pro Xaa Pro Asp Glu Pro Cys Ile Lys Cys Pro Glu Asn 
            580                 585                 590         


Leu Gly Glu Gln Gln Leu Glu Ser Leu Glu Pro Glu Asp Pro Ser Leu 
        595                 600                 605             


Arg Ile Xaa Xaa Val Lys Ile Gln Xaa Glu Gln Gln Arg Ile Ser Phe 
    610                 615                 620                 


Pro Pro Ser Cys Pro Asp Ala Val Val Ala Xaa Pro Pro Gly Ala Ser 
625                 630                 635                 640 


Pro Pro Val Lys Asp Arg Leu Arg Val Xaa Ser Ala Glu Ile Lys Leu 
                645                 650                 655     


Gly Lys Asn Arg Xaa Glu Ala Glu Val Lys Arg Tyr Xaa Glu Glu Lys 
            660                 665                 670         


Glu Arg Leu Glu Lys Lys Lys Glu Glu Ile Arg Gly His Leu Ala Gln 
        675                 680                 685             


Leu Arg Lys Glu Lys Arg Glu Leu Lys Glu Xaa Leu Leu Lys Cys Xaa 
    690                 695                 700                 


Asp Lys Glu Val Leu Ala Ser Leu Glu Gln Lys Leu Lys Glu Ile Asp 
705                 710                 715                 720 


Glu Glu Cys Arg Gly Glu Glu Ser Arg Arg Val Asp Leu Glu Leu Ser 
                725                 730                 735     


Ile Met Glu Val Lys Asp Asn Leu Lys Lys Ala Glu Ala Gly Pro Val 
            740                 745                 750         


Xaa Leu Gly Xaa Xaa Val Asp Xaa Xaa His Leu Glu Asn Val Ser Pro 
        755                 760                 765             


Arg Pro Lys Ala Val Xaa Pro Ala Ser Ala Pro Asp Cys Xaa Pro Val 
    770                 775                 780                 


Asn Ser Ala Xaa Xaa Leu Lys Asn Arg Pro Leu Ser Val Val Val Xaa 
785                 790                 795                 800 


Gly Lys Gly Xaa Val Leu Gln Lys Ala Lys Glu Trp Glu Lys Lys Gly 
                805                 810                 815     


Ala Ser 
        


<210> 1876
<211> 312
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<400> 1876
Met Glu Arg Tyr Lys Ala Gln Gly Cys Cys Cys Leu Val Val Gln Arg 
1               5                   10                  15      


Arg Ile Arg Gln Val Ser Ala Ser Leu Glu Gln Leu Leu Xaa Glu Leu 
            20                  25                  30          


Asp Asp Phe Leu Lys Ile Leu Asp Gln Glu Asn Leu Ser Ser Xaa Ala 
        35                  40                  45              


Leu Val Lys Lys Ser Cys Leu Ala Glu Leu Leu Arg Leu Tyr Xaa Lys 
    50                  55                  60                  


Ser Ser Ser Ser Asp Glu Glu Tyr Ile Tyr Met Asn Lys Val Xaa Ile 
65                  70                  75                  80  


Asn Lys Gln Gln Asn Ala Glu Ser Gln Gly Lys Ala Pro Glu Glu Gln 
                85                  90                  95      


Gly Leu Leu Pro Asn Gly Glu Pro Ser Gln His Ser Ser Ala Pro Gln 
            100                 105                 110         


Lys Ser Leu Pro Asp Leu Pro Pro Pro Lys Met Ile Pro Glu Arg Lys 
        115                 120                 125             


Gln Leu Ala Ile Pro Lys Xaa Glu Ser Pro Glu Gly Tyr Tyr Glu Glu 
    130                 135                 140                 


Ala Glu Pro Tyr Asp Xaa Ser Leu Asn Glu Asp Gly Glu Ala Val Ser 
145                 150                 155                 160 


Ser Ser Tyr Glu Ser Tyr Asp Glu Glu Asp Gly Ser Lys Gly Lys Ser 
                165                 170                 175     


Ala Pro Tyr Gln Trp Pro Ser Pro Glu Ala Gly Ile Glu Leu Met Arg 
            180                 185                 190         


Asp Ala Arg Ile Cys Ala Phe Leu Trp Arg Lys Lys Trp Leu Gly Gln 
        195                 200                 205             


Trp Ala Lys Gln Leu Cys Val Ile Lys Asp Asn Arg Leu Leu Cys Tyr 
    210                 215                 220                 


Lys Ser Ser Lys Asp His Ser Pro Gln Leu Asp Val Asn Leu Leu Gly 
225                 230                 235                 240 


Ser Ser Val Ile His Lys Glu Lys Gln Val Arg Lys Lys Glu His Lys 
                245                 250                 255     


Leu Lys Ile Xaa Pro Met Asn Ala Asp Val Ile Val Leu Gly Leu Gln 
            260                 265                 270         


Ser Lys Asp Gln Ala Glu Gln Trp Leu Arg Val Ile Gln Glu Val Ser 
        275                 280                 285             


Gly Leu Pro Ser Glu Gly Ala Ser Glu Gly Asn Gln Tyr Xaa Pro Asp 
    290                 295                 300                 


Ala Gln Arg Phe Asn Cys Gln Lys 
305                 310         


<210> 1877
<211> 167
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<400> 1877
Ala Ala Asp Cys His Leu Ser Arg Ile Val Gln Ala Xaa Xaa Leu Leu 
1               5                   10                  15      


Xaa Met Asp Lys Tyr Ala Pro Asp Asp Ile Pro Asn Ile Asn Ser Xaa 
            20                  25                  30          


Cys Phe Lys Leu Asn Ser Leu Gln Leu Gln Ala Leu Leu Gln Asn Tyr 
        35                  40                  45              


His Cys Ala Pro Asp Glu Pro Phe Ile Pro Xaa Asp Leu Ile Glu Asn 
    50                  55                  60                  


Val Val Xaa Val Ala Glu Asn Xaa Ala Asp Glu Leu Ala Arg Ser Asp 
65                  70                  75                  80  


Gly Arg Glu Val Gln Leu Glu Glu Asp Pro Asp Leu Gln Leu Pro Phe 
                85                  90                  95      


Leu Leu Pro Glu Asp Gly Tyr Ser Cys Asp Val Val Arg Asn Ile Pro 
            100                 105                 110         


Asn Gly Leu Gln Glu Phe Leu Asp Pro Leu Cys Gln Arg Gly Phe Cys 
        115                 120                 125             


Arg Leu Ile Pro His Xaa Arg Ser Pro Gly Xaa Trp Xaa Ile Tyr Phe 
    130                 135                 140                 


Glu Gly Ala Asp Tyr Glu Ser His Leu Leu Arg Glu Asn Xaa Glu Leu 
145                 150                 155                 160 


Ala Ser Ile Leu Arg Val Pro 
                165         


<210> 1878
<211> 1781
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1152)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1161)..(1161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1184)..(1184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1191)..(1191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1293)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1304)..(1304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1321)..(1321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1405)..(1405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1417)..(1417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1428)..(1428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1435)..(1435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1448)..(1448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1549)..(1549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1599)..(1599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1674)..(1674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1684)..(1684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1711)..(1711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1747)..(1747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1772)..(1772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1780)..(1780)
<223> Selenocysteine

<400> 1878
Met Arg Phe Tyr Phe Gln Asp Lys Ala Ala Gly Asn Phe Ala Xaa Lys 
1               5                   10                  15      


Cys Ile Arg Val Ser Ser Xaa Ala Xaa Xaa Gln Asp Val Ile Glu Xaa 
            20                  25                  30          


Leu Ala Glu Lys Phe Arg Pro Asp Met Arg Met Leu Ser Ser Pro Lys 
        35                  40                  45              


Tyr Ser Leu Tyr Glu Val His Val Ser Gly Glu Glu Arg Arg Leu Asp 
    50                  55                  60                  


Ile Asp Glu Lys Pro Leu Val Val Gln Leu Asn Trp Asn Lys Asp Asp 
65                  70                  75                  80  


Arg Glu Gly Arg Phe Val Leu Lys Asn Glu Asn Asp Ala Ile Pro Pro 
                85                  90                  95      


Lys Lys Ala Gln Ser Asn Gly Pro Glu Lys Gln Glu Lys Glu Gly Val 
            100                 105                 110         


Ile Gln Asn Phe Lys Arg Xaa Leu Ser Lys Lys Glu Lys Lys Glu Lys 
        115                 120                 125             


Lys Lys Arg Glu Lys Glu Ala Leu Arg Gln Ala Ser Asp Lys Asp Asp 
    130                 135                 140                 


Arg Pro Phe Gln Gly Glu Asp Val Glu Asn Ser Arg Leu Ala Ala Glu 
145                 150                 155                 160 


Val Tyr Lys Asp Met Pro Glu Xaa Ser Phe Xaa Arg Xaa Ile Ser Asn 
                165                 170                 175     


Pro Glu Val Val Met Lys Arg Arg Arg Gln Gln Lys Leu Glu Lys Arg 
            180                 185                 190         


Met Gln Glu Phe Arg Ser Ser Asp Gly Arg Pro Asp Ser Gly Gly Xaa 
        195                 200                 205             


Leu Arg Ile Tyr Ala Asp Ser Leu Lys Pro Asn Ile Pro Tyr Lys Xaa 
    210                 215                 220                 


Ile Leu Leu Ser Xaa Xaa Asp Pro Ala Asp Phe Ala Val Ala Glu Ala 
225                 230                 235                 240 


Leu Glu Lys Tyr Gly Leu Glu Lys Glu Asn Pro Lys Asp Tyr Cys Ile 
                245                 250                 255     


Ala Arg Val Met Leu Pro Pro Gly Ala Gln His Ser Asp Glu Lys Gly 
            260                 265                 270         


Ala Lys Glu Ile Ile Leu Asp Asp Asp Glu Cys Pro Leu Gln Ile Phe 
        275                 280                 285             


Arg Glu Trp Pro Ser Asp Lys Gly Ile Leu Val Phe Gln Leu Lys Arg 
    290                 295                 300                 


Arg Pro Pro Asp His Ile Pro Lys Lys Xaa Lys Lys His Leu Glu Gly 
305                 310                 315                 320 


Lys Xaa Pro Lys Gly Lys Glu Arg Ala Asp Gly Ser Gly Tyr Gly Ser 
                325                 330                 335     


Xaa Leu Pro Pro Glu Lys Leu Pro Tyr Leu Val Glu Leu Ser Pro Gly 
            340                 345                 350         


Arg Arg Asn His Phe Ala Tyr Tyr Asn Tyr His Xaa Tyr Glu Asp Gly 
        355                 360                 365             


Ser Asp Ser Arg Asp Lys Pro Lys Leu Tyr Arg Leu Gln Leu Ser Val 
    370                 375                 380                 


Xaa Glu Val Gly Xaa Glu Lys Leu Asp Asp Asn Ser Ile Gln Leu Phe 
385                 390                 395                 400 


Gly Pro Gly Ile Gln Pro His His Cys Asp Leu Xaa Asn Met Asp Gly 
                405                 410                 415     


Val Val Xaa Val Xaa Pro Arg Ser Met Asp Ala Glu Xaa Tyr Val Glu 
            420                 425                 430         


Gly Gln Arg Ile Ser Glu Xaa Xaa Met Leu Gln Ser Gly Met Lys Val 
        435                 440                 445             


Gln Phe Gly Ala Ser His Val Phe Lys Phe Val Asp Pro Ser Gln Asp 
    450                 455                 460                 


His Ala Leu Ala Lys Arg Ser Val Asp Gly Gly Leu Met Val Lys Gly 
465                 470                 475                 480 


Pro Arg His Lys Pro Gly Ile Val Gln Glu Xaa Xaa Phe Asp Leu Gly 
                485                 490                 495     


Gly Asp Ile His Ser Gly Xaa Ala Leu Pro Xaa Ser Lys Ser Xaa Xaa 
            500                 505                 510         


Arg Leu Asp Ser Asp Arg Val Ser Ser Ala Ser Ser Xaa Ala Glu Arg 
        515                 520                 525             


Gly Met Val Lys Pro Met Ile Arg Val Glu Gln Gln Pro Asp Tyr Arg 
    530                 535                 540                 


Arg Gln Glu Ser Arg Xaa Gln Asp Ala Ser Gly Pro Glu Leu Ile Leu 
545                 550                 555                 560 


Pro Ala Ser Ile Glu Phe Arg Glu Ser Ser Glu Asp Ser Phe Leu Ser 
                565                 570                 575     


Ala Ile Ile Asn Tyr Xaa Asn Ser Ser Xaa Val His Phe Lys Leu Ser 
            580                 585                 590         


Pro Xaa Tyr Val Leu Tyr Met Ala Cys Arg Tyr Val Leu Ser Asn Gln 
        595                 600                 605             


Tyr Arg Pro Asp Ile Ser Pro Xaa Glu Arg Xaa His Lys Val Ile Ala 
    610                 615                 620                 


Val Val Asn Lys Met Val Ser Met Met Glu Gly Val Ile Gln Lys Gln 
625                 630                 635                 640 


Lys Asn Ile Ala Gly Ala Leu Ala Phe Trp Met Ala Asn Ala Ser Glu 
                645                 650                 655     


Leu Leu Asn Phe Ile Lys Gln Asp Arg Asp Leu Ser Arg Ile Xaa Leu 
            660                 665                 670         


Asp Ala Gln Asp Val Leu Ala His Leu Val Gln Met Ala Phe Lys Tyr 
        675                 680                 685             


Leu Val His Cys Leu Gln Ser Glu Leu Asn Asn Tyr Met Pro Ala Phe 
    690                 695                 700                 


Leu Asp Asp Pro Glu Glu Asn Ser Leu Gln Arg Pro Lys Ile Asp Asp 
705                 710                 715                 720 


Val Leu His Xaa Leu Xaa Gly Ala Met Ser Leu Leu Arg Arg Cys Arg 
                725                 730                 735     


Val Asn Ala Ala Leu Xaa Ile Gln Leu Phe Ser Gln Leu Phe His Phe 
            740                 745                 750         


Ile Asn Met Trp Leu Phe Asn Arg Leu Val Xaa Asp Pro Asp Ser Gly 
        755                 760                 765             


Leu Cys Ser His Tyr Trp Gly Ala Ile Ile Arg Gln Gln Leu Gly His 
    770                 775                 780                 


Ile Glu Ala Trp Ala Glu Lys Gln Gly Leu Glu Leu Ala Ala Asp Cys 
785                 790                 795                 800 


His Leu Ser Arg Ile Val Gln Ala Xaa Xaa Leu Leu Xaa Met Asp Lys 
                805                 810                 815     


Tyr Ala Pro Asp Asp Ile Pro Asn Ile Asn Ser Xaa Cys Phe Lys Leu 
            820                 825                 830         


Asn Ser Leu Gln Leu Gln Ala Leu Leu Gln Asn Tyr His Cys Ala Pro 
        835                 840                 845             


Asp Glu Pro Phe Ile Pro Xaa Asp Leu Ile Glu Asn Val Val Xaa Val 
    850                 855                 860                 


Ala Glu Asn Xaa Ala Asp Glu Leu Ala Arg Ser Asp Gly Arg Glu Val 
865                 870                 875                 880 


Gln Leu Glu Glu Asp Pro Asp Leu Gln Leu Pro Phe Leu Leu Pro Glu 
                885                 890                 895     


Asp Gly Tyr Ser Cys Asp Val Val Arg Asn Ile Pro Asn Gly Leu Gln 
            900                 905                 910         


Glu Phe Leu Asp Pro Leu Cys Gln Arg Gly Phe Cys Arg Leu Ile Pro 
        915                 920                 925             


His Xaa Arg Ser Pro Gly Xaa Trp Xaa Ile Tyr Phe Glu Gly Ala Asp 
    930                 935                 940                 


Tyr Glu Ser His Leu Leu Arg Glu Asn Xaa Glu Leu Ala Gln Pro Leu 
945                 950                 955                 960 


Arg Lys Glu Pro Glu Ile Ile Xaa Val Xaa Leu Lys Lys Gln Asn Gly 
                965                 970                 975     


Met Gly Leu Ser Ile Val Ala Ala Lys Gly Ala Gly Gln Asp Lys Leu 
            980                 985                 990         


Gly Ile Tyr Val Lys Ser Val Val  Lys Gly Gly Ala Ala  Asp Val Asp 
        995                 1000                 1005             


Gly Arg  Leu Ala Ala Gly Asp  Gln Leu Leu Ser Val  Asp Gly Arg 
    1010                 1015                 1020             


Ser Leu  Val Gly Leu Ser Gln  Glu Arg Ala Ala Glu  Leu Met Xaa 
    1025                 1030                 1035             


Arg Xaa  Ser Ser Val Val Xaa  Leu Glu Val Ala Lys  Gln Gly Ala 
    1040                 1045                 1050             


Ile Tyr  His Gly Leu Ala Xaa  Leu Leu Asn Gln Pro  Ser Pro Met 
    1055                 1060                 1065             


Met Gln  Arg Ile Ser Asp Arg  Arg Gly Ser Gly Lys  Pro Arg Pro 
    1070                 1075                 1080             


Lys Ser  Glu Gly Phe Glu Leu  Tyr Asn Asn Ser Xaa  Gln Asn Gly 
    1085                 1090                 1095             


Ser Pro  Glu Ser Pro Gln Leu  Pro Trp Ala Glu Tyr  Ser Glu Pro 
    1100                 1105                 1110             


Lys Lys  Leu Pro Gly Asp Asp  Arg Leu Met Lys Asn  Arg Ala Asp 
    1115                 1120                 1125             


His Arg  Ser Ser Pro Asn Val  Ala Asn Gln Pro Pro  Ser Pro Gly 
    1130                 1135                 1140             


Gly Lys  Ser Ala Tyr Ala Ser  Gly Xaa Xaa Ala Lys  Ile Xaa Ser 
    1145                 1150                 1155             


Val Ser  Xaa Gly Asn Leu Cys  Xaa Glu Glu Gln Xaa  Pro Pro Pro 
    1160                 1165                 1170             


Arg Pro  Glu Ala Tyr Pro Ile  Pro Xaa Gln Xaa Tyr  Xaa Arg Glu 
    1175                 1180                 1185             


Tyr Phe  Xaa Phe Pro Ala Ser  Lys Ser Gln Asp Arg  Met Ala Pro 
    1190                 1195                 1200             


Pro Gln  Asn Gln Trp Pro Asn  Tyr Glu Glu Lys Pro  His Met His 
    1205                 1210                 1215             


Xaa Asp  Ser Asn His Ser Ser  Ile Ala Ile Gln Arg  Val Xaa Arg 
    1220                 1225                 1230             


Ser Gln  Glu Glu Leu Arg Glu  Asp Lys Ala Tyr Gln  Leu Glu Arg 
    1235                 1240                 1245             


His Arg  Ile Glu Ala Ala Met  Asp Arg Lys Ser Asp  Ser Asp Met 
    1250                 1255                 1260             


Trp Ile  Asn Gln Ser Ser Ser  Leu Asp Ser Ser Xaa  Ser Ser Gln 
    1265                 1270                 1275             


Glu His  Leu Asn His Ser Ser  Lys Ser Val Xaa Pro  Ala Ser Xaa 
    1280                 1285                 1290             


Leu Xaa  Lys Ser Gly Pro Gly  Arg Trp Lys Xaa Pro  Ala Ala Ile 
    1295                 1300                 1305             


Pro Ala  Xaa Pro Val Ala Val  Ser Gln Pro Ile Arg  Xaa Asp Leu 
    1310                 1315                 1320             


Pro Pro  Pro Pro Pro Pro Pro  Pro Val His Tyr Ala  Gly Asp Phe 
    1325                 1330                 1335             


Asp Gly  Met Ser Met Asp Leu  Pro Leu Pro Pro Pro  Pro Ser Ala 
    1340                 1345                 1350             


Asn Gln  Ile Gly Leu Pro Ser  Ala Gln Val Ala Ala  Ala Glu Arg 
    1355                 1360                 1365             


Arg Lys  Arg Glu Glu His Gln  Arg Trp Tyr Glu Lys  Glu Lys Ala 
    1370                 1375                 1380             


Arg Leu  Glu Glu Glu Arg Glu  Arg Lys Arg Arg Glu  Gln Glu Arg 
    1385                 1390                 1395             


Lys Leu  Gly Gln Met Arg Xaa  Gln Ser Leu Asn Pro  Ala Pro Phe 
    1400                 1405                 1410             


Ser Pro  Leu Xaa Ala Gln Gln  Met Lys Pro Glu Lys  Pro Ser Xaa 
    1415                 1420                 1425             


Leu Gln  Arg Pro Gln Glu Xaa  Val Ile Arg Glu Leu  Gln Pro Gln 
    1430                 1435                 1440             


Gln Gln  Pro Arg Xaa Ile Glu  Arg Arg Asp Leu Gln  Tyr Ile Xaa 
    1445                 1450                 1455             


Val Ser  Lys Glu Glu Leu Ser  Ser Gly Asp Ser Leu  Ser Pro Asp 
    1460                 1465                 1470             


Pro Trp  Lys Arg Asp Ala Lys  Glu Lys Leu Glu Lys  Gln Gln Gln 
    1475                 1480                 1485             


Met His  Ile Val Asp Met Leu  Ser Lys Glu Ile Gln  Glu Leu Gln 
    1490                 1495                 1500             


Ser Lys  Pro Asp Arg Ser Ala  Glu Glu Ser Asp Arg  Leu Arg Lys 
    1505                 1510                 1515             


Leu Met  Leu Glu Trp Gln Phe  Gln Lys Arg Leu Gln  Glu Ser Lys 
    1520                 1525                 1530             


Gln Lys  Asp Glu Asp Asp Glu  Glu Glu Glu Asp Asp  Asp Val Asp 
    1535                 1540                 1545             


Xaa Met  Leu Ile Met Gln Arg  Leu Glu Ala Glu Arg  Arg Ala Arg 
    1550                 1555                 1560             


Asp Glu  Glu Arg Arg Arg Gln  Gln Gln Leu Glu Glu  Met Arg Lys 
    1565                 1570                 1575             


Arg Glu  Ala Glu Asp Arg Ala  Arg Gln Glu Glu Glu  Arg Arg Arg 
    1580                 1585                 1590             


Gln Glu  Glu Glu Arg Xaa Lys  Arg Asp Ala Glu Glu  Lys Arg Arg 
    1595                 1600                 1605             


Gln Glu  Glu Gly Tyr Tyr Ser  Arg Leu Glu Ala Glu  Arg Arg Arg 
    1610                 1615                 1620             


Gln His  Asp Glu Ala Ala Arg  Arg Leu Leu Glu Pro  Glu Ala Pro 
    1625                 1630                 1635             


Gly Leu  Cys Arg Pro Pro Leu  Pro Arg Asp Tyr Glu  Pro Pro Ser 
    1640                 1645                 1650             


Pro Ser  Pro Ala Pro Gly Ala  Pro Pro Pro Pro Pro  Gln Arg Asn 
    1655                 1660                 1665             


Ala Ser  Tyr Leu Lys Xaa Gln  Val Leu Ser Pro Asp  Ser Leu Phe 
    1670                 1675                 1680             


Xaa Ala  Lys Phe Val Ala Tyr  Asn Glu Glu Glu Glu  Glu Glu Asp 
    1685                 1690                 1695             


Cys Ser  Leu Ala Gly Pro Asn  Ser Tyr Pro Gly Ser  Xaa Gly Ala 
    1700                 1705                 1710             


Ala Val  Gly Ala His Asp Ala  Cys Arg Asp Ala Lys  Glu Lys Arg 
    1715                 1720                 1725             


Ser Lys  Ser Gln Asp Ala Asp  Ser Pro Gly Ser Ser  Gly Ala Pro 
    1730                 1735                 1740             


Glu Asn  Leu Xaa Phe Lys Glu  Arg Gln Arg Leu Phe  Ser Gln Gly 
    1745                 1750                 1755             


Gln Asp  Val Ser Asn Lys Val  Lys Ala Ser Arg Lys  Leu Xaa Glu 
    1760                 1765                 1770             


Leu Glu  Asn Glu Leu Asn Xaa  Lys 
    1775                 1780     


<210> 1879
<211> 250
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<400> 1879
Met Ser Ala Gly Gly Arg Asp Glu Glu Arg Arg Lys Leu Ala Asp Ile 
1               5                   10                  15      


Ile His His Trp Asn Ala Asn Arg Leu Asp Leu Phe Glu Ile Ser Gln 
            20                  25                  30          


Pro Xaa Glu Asp Leu Glu Phe His Gly Val Met Arg Phe Tyr Phe Gln 
        35                  40                  45              


Asp Lys Ala Ala Gly Asn Phe Ala Xaa Lys Cys Ile Arg Val Ser Ser 
    50                  55                  60                  


Xaa Ala Xaa Xaa Gln Asp Val Ile Glu Xaa Leu Ala Glu Lys Phe Arg 
65                  70                  75                  80  


Pro Asp Met Arg Met Leu Ser Ser Pro Lys Tyr Ser Leu Tyr Glu Val 
                85                  90                  95      


His Val Ser Gly Glu Glu Arg Arg Leu Asp Ile Asp Glu Lys Pro Leu 
            100                 105                 110         


Val Val Gln Leu Asn Trp Asn Lys Asp Asp Arg Glu Gly Arg Phe Val 
        115                 120                 125             


Leu Lys Asn Glu Asn Asp Ala Ile Pro Pro Lys Ala Gln Ser Asn Gly 
    130                 135                 140                 


Pro Glu Lys Gln Glu Lys Glu Gly Val Ile Gln Asn Phe Lys Arg Xaa 
145                 150                 155                 160 


Leu Ser Lys Lys Glu Lys Lys Glu Lys Lys Lys Arg Glu Lys Glu Ala 
                165                 170                 175     


Leu Arg Gln Ala Ser Asp Lys Asp Asp Arg Pro Phe Gln Gly Glu Asp 
            180                 185                 190         


Val Glu Asn Ser Arg Leu Ala Ala Glu Val Tyr Lys Asp Met Pro Glu 
        195                 200                 205             


Xaa Ser Phe Xaa Arg Xaa Ile Ser Asn Pro Glu Val Val Met Lys Arg 
    210                 215                 220                 


Arg Arg Gln Gln Lys Leu Glu Lys Arg Met Gln Glu Phe Arg Ser Ser 
225                 230                 235                 240 


Asp Gly Arg Pro Asp Ser Gly Gly Xaa Leu 
                245                 250 


<210> 1880
<211> 247
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<400> 1880
Met Ser Ala Gly Gly Arg Asp Glu Glu Arg Arg Lys Leu Ala Asp Ile 
1               5                   10                  15      


Ile His His Trp Asn Ala Asn Arg Leu Asp Leu Phe Glu Ile Ser Gln 
            20                  25                  30          


Pro Xaa Glu Asp Leu Glu Phe His Gly Val Met Arg Phe Tyr Phe Gln 
        35                  40                  45              


Asp Lys Ala Ala Gly Asn Phe Ala Xaa Lys Cys Ile Arg Val Ser Ser 
    50                  55                  60                  


Xaa Ala Xaa Xaa Gln Asp Val Ile Glu Xaa Leu Ala Glu Lys Phe Arg 
65                  70                  75                  80  


Pro Asp Met Arg Met Leu Ser Ser Pro Lys Tyr Ser Leu Tyr Glu Val 
                85                  90                  95      


His Val Ser Gly Glu Glu Arg Arg Leu Asp Ile Asp Glu Lys Pro Leu 
            100                 105                 110         


Val Val Gln Leu Asn Trp Asn Lys Asp Asp Arg Glu Gly Arg Phe Val 
        115                 120                 125             


Leu Lys Asn Glu Asn Asp Ala Ile Pro Pro Lys Lys Ala Gln Ser Asn 
    130                 135                 140                 


Gly Pro Glu Lys Gln Glu Lys Glu Gly Val Ile Gln Asn Phe Lys Arg 
145                 150                 155                 160 


Xaa Leu Ser Lys Lys Glu Lys Lys Glu Lys Lys Lys Arg Glu Lys Glu 
                165                 170                 175     


Ala Leu Arg Gln Ala Ser Asp Lys Asp Asp Arg Pro Phe Gln Gly Glu 
            180                 185                 190         


Asp Val Glu Asn Ser Arg Leu Ala Ala Glu Val Tyr Lys Asp Met Pro 
        195                 200                 205             


Glu Xaa Ser Phe Xaa Arg Xaa Ile Ser Asn Pro Glu Val Val Met Lys 
    210                 215                 220                 


Arg Arg Arg Gln Gln Lys Leu Glu Lys Arg Met Gln Glu Phe Arg Ser 
225                 230                 235                 240 


Ser Asp Gly Arg Pro Asp Ser 
                245         


<210> 1881
<211> 1743
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1176)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1190)..(1190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1206)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1208)..(1208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1243)..(1243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1299)..(1299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1313)..(1313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1317)..(1317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1319)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1328)..(1328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1429)..(1429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1452)..(1452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1459)..(1459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1482)..(1482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1625)..(1625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1673)..(1673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1709)..(1709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1734)..(1734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1742)..(1742)
<223> Selenocysteine

<400> 1881
Met Ser Ala Gly Gly Arg Asp Glu Glu Arg Arg Lys Leu Ala Asp Ile 
1               5                   10                  15      


Ile His His Trp Asn Ala Asn Arg Leu Asp Leu Phe Glu Ile Ser Gln 
            20                  25                  30          


Pro Xaa Glu Asp Leu Glu Phe His Gly Val Met Arg Phe Tyr Phe Gln 
        35                  40                  45              


Asp Lys Ala Ala Gly Asn Phe Ala Xaa Lys Cys Ile Arg Val Ser Ser 
    50                  55                  60                  


Xaa Ala Xaa Xaa Gln Asp Val Ile Glu Xaa Leu Ala Glu Lys Phe Arg 
65                  70                  75                  80  


Pro Asp Met Arg Met Leu Ser Ser Pro Lys Tyr Ser Leu Tyr Glu Val 
                85                  90                  95      


His Val Ser Gly Glu Arg Arg Leu Asp Ile Asp Glu Lys Pro Leu Val 
            100                 105                 110         


Val Gln Leu Asn Trp Asn Lys Asp Asp Arg Glu Gly Arg Phe Val Leu 
        115                 120                 125             


Lys Asn Glu Asn Asp Ala Ile Pro Pro Lys Ala Gln Ser Asn Gly Pro 
    130                 135                 140                 


Glu Lys Gln Glu Lys Glu Gly Val Ile Gln Asn Phe Lys Arg Xaa Leu 
145                 150                 155                 160 


Ser Lys Lys Glu Lys Lys Glu Lys Lys Lys Arg Glu Lys Glu Ala Leu 
                165                 170                 175     


Arg Gln Ala Ser Asp Lys Asp Asp Arg Pro Phe Gln Gly Glu Asp Val 
            180                 185                 190         


Glu Asn Ser Arg Leu Ala Ala Glu Val Tyr Lys Asp Met Pro Glu Xaa 
        195                 200                 205             


Ser Phe Xaa Arg Xaa Ile Ser Asn Pro Glu Val Val Met Lys Arg Arg 
    210                 215                 220                 


Arg Gln Gln Lys Leu Glu Lys Arg Met Gln Glu Phe Arg Ser Ser Asp 
225                 230                 235                 240 


Gly Arg Pro Asp Ser Gly Gly Xaa Leu Arg Ile Tyr Ala Asp Ser Leu 
                245                 250                 255     


Lys Pro Asn Ile Pro Tyr Lys Xaa Ile Leu Leu Ser Xaa Xaa Asp Pro 
            260                 265                 270         


Ala Asp Phe Ala Val Ala Glu Ala Leu Glu Lys Tyr Gly Leu Glu Lys 
        275                 280                 285             


Glu Asn Pro Lys Asp Tyr Cys Ile Ala Arg Val Met Leu Pro Pro Gly 
    290                 295                 300                 


Ala Gln His Ser Asp Glu Lys Gly Ala Lys Glu Ile Ile Leu Asp Asp 
305                 310                 315                 320 


Asp Glu Cys Pro Leu Gln Ile Phe Arg Glu Trp Pro Ser Asp Lys Gly 
                325                 330                 335     


Ile Leu Val Phe Gln Leu Lys Arg Arg Pro Pro Asp His Ile Pro Lys 
            340                 345                 350         


Lys Xaa Lys Lys His Leu Glu Gly Lys Xaa Pro Lys Gly Lys Glu Arg 
        355                 360                 365             


Ala Asp Gly Ser Gly Tyr Gly Ser Xaa Leu Pro Pro Glu Lys Leu Pro 
    370                 375                 380                 


Tyr Leu Val Glu Leu Ser Pro Asp Gly Ser Asp Ser Arg Asp Lys Pro 
385                 390                 395                 400 


Lys Leu Tyr Arg Leu Gln Leu Ser Val Xaa Glu Val Gly Xaa Glu Lys 
                405                 410                 415     


Leu Asp Asp Asn Ser Ile Gln Leu Phe Gly Pro Gly Ile Gln Pro His 
            420                 425                 430         


His Cys Asp Leu Xaa Asn Met Asp Gly Val Val Xaa Val Xaa Pro Arg 
        435                 440                 445             


Ser Met Asp Ala Glu Xaa Tyr Val Glu Gly Gln Arg Ile Ser Glu Xaa 
    450                 455                 460                 


Xaa Met Leu Gln Ser Gly Met Lys Val Gln Phe Gly Ala Ser His Val 
465                 470                 475                 480 


Phe Lys Phe Val Asp Pro Ser Gln Asp His Ala Leu Ala Lys Arg Ser 
                485                 490                 495     


Val Asp Gly Gly Leu Met Val Lys Gly Pro Arg His Lys Pro Gly Ile 
            500                 505                 510         


Val Gln Glu Xaa Xaa Phe Asp Leu Gly Gly Asp Ile His Ser Gly Xaa 
        515                 520                 525             


Ala Leu Pro Xaa Ser Lys Ser Xaa Xaa Arg Leu Asp Ser Asp Arg Val 
    530                 535                 540                 


Ser Ser Ala Ser Ser Xaa Ala Glu Arg Gly Met Val Lys Pro Met Ile 
545                 550                 555                 560 


Arg Val Glu Gln Gln Pro Asp Tyr Arg Arg Gln Glu Ser Arg Xaa Gln 
                565                 570                 575     


Asp Ala Ser Gly Pro Glu Leu Ile Leu Pro Ala Ser Ile Glu Phe Arg 
            580                 585                 590         


Glu Ser Ser Glu Asp Ser Phe Leu Ser Ala Ile Ile Asn Tyr Xaa Asn 
        595                 600                 605             


Ser Ser Xaa Val His Phe Lys Leu Ser Pro Xaa Tyr Val Leu Tyr Met 
    610                 615                 620                 


Ala Cys Arg Tyr Val Leu Ser Asn Gln Tyr Arg Pro Asp Ile Ser Pro 
625                 630                 635                 640 


Xaa Glu Arg Xaa His Lys Val Ile Ala Val Val Asn Lys Met Val Ser 
                645                 650                 655     


Met Met Glu Gly Val Ile Gln Lys Gln Lys Asn Ile Ala Gly Ala Leu 
            660                 665                 670         


Ala Phe Trp Met Ala Asn Ala Ser Glu Leu Leu Asn Phe Ile Lys Gln 
        675                 680                 685             


Asp Arg Asp Leu Ser Arg Ile Xaa Leu Asp Ala Gln Asp Val Leu Ala 
    690                 695                 700                 


His Leu Val Gln Met Ala Phe Lys Tyr Leu Val His Cys Leu Gln Ser 
705                 710                 715                 720 


Glu Leu Asn Asn Tyr Met Pro Ala Phe Leu Asp Asp Pro Glu Glu Asn 
                725                 730                 735     


Ser Leu Gln Arg Pro Lys Ile Asp Asp Val Leu His Xaa Leu Xaa Gly 
            740                 745                 750         


Ala Met Ser Leu Leu Arg Arg Cys Arg Val Asn Ala Ala Leu Xaa Ile 
        755                 760                 765             


Gln Leu Phe Ser Gln Leu Phe His Phe Ile Asn Met Trp Leu Phe Asn 
    770                 775                 780                 


Arg Leu Val Xaa Asp Pro Asp Ser Gly Leu Cys Ser His Tyr Trp Gly 
785                 790                 795                 800 


Ala Ile Ile Arg Gln Gln Leu Gly His Ile Glu Ala Trp Ala Glu Lys 
                805                 810                 815     


Gln Gly Leu Glu Leu Ala Ala Asp Cys His Leu Ser Arg Ile Val Gln 
            820                 825                 830         


Ala Xaa Xaa Leu Leu Xaa Met Asp Lys Tyr Ala Pro Asp Asp Ile Pro 
        835                 840                 845             


Asn Ile Asn Ser Xaa Cys Phe Lys Leu Asn Ser Leu Gln Leu Gln Ala 
    850                 855                 860                 


Leu Leu Gln Asn Tyr His Cys Ala Pro Asp Glu Pro Phe Ile Pro Xaa 
865                 870                 875                 880 


Asp Leu Ile Glu Asn Val Val Xaa Val Ala Glu Asn Xaa Ala Asp Glu 
                885                 890                 895     


Leu Ala Arg Ser Asp Gly Arg Glu Val Gln Leu Glu Glu Asp Pro Asp 
            900                 905                 910         


Leu Gln Leu Pro Phe Leu Leu Pro Glu Asp Gly Tyr Ser Cys Asp Val 
        915                 920                 925             


Val Arg Asn Ile Pro Asn Gly Leu Gln Glu Phe Leu Asp Pro Leu Cys 
    930                 935                 940                 


Gln Arg Gly Phe Cys Arg Leu Ile Pro His Xaa Arg Ser Pro Gly Xaa 
945                 950                 955                 960 


Trp Xaa Ile Tyr Phe Glu Gly Ala Asp Tyr Glu Ser His Leu Leu Arg 
                965                 970                 975     


Glu Asn Xaa Glu Leu Ala Gln Pro Leu Arg Lys Glu Pro Glu Ile Ile 
            980                 985                 990         


Xaa Val Xaa Leu Lys Lys Gln Asn  Gly Met Gly Leu Ser  Ile Val Ala 
        995                 1000                 1005             


Ala Lys  Gly Ala Gly Gln Asp  Lys Leu Gly Ile Tyr  Val Lys Ser 
    1010                 1015                 1020             


Val Val  Lys Gly Gly Ala Ala  Asp Asp Gly Arg Leu  Ala Ala Gly 
    1025                 1030                 1035             


Asp Gln  Leu Leu Ser Val Asp  Gly Arg Ser Leu Val  Gly Leu Ser 
    1040                 1045                 1050             


Gln Glu  Arg Ala Ala Glu Leu  Met Xaa Arg Xaa Ser  Ser Val Val 
    1055                 1060                 1065             


Xaa Leu  Glu Val Ala Lys Gln  Gly Ala Ile Tyr His  Gly Leu Ala 
    1070                 1075                 1080             


Xaa Leu  Leu Asn Gln Pro Ser  Pro Met Met Gln Arg  Ile Ser Asp 
    1085                 1090                 1095             


Arg Arg  Gly Ser Gly Lys Pro  Arg Pro Lys Ser Glu  Gly Phe Glu 
    1100                 1105                 1110             


Leu Tyr  Asn Asn Ser Xaa Gln  Asn Gly Ser Pro Glu  Ser Pro Gln 
    1115                 1120                 1125             


Leu Pro  Trp Ala Glu Tyr Ser  Glu Pro Lys Lys Leu  Pro Gly Asp 
    1130                 1135                 1140             


Asp Arg  Leu Met Lys Asn Arg  Ala Asp His Arg Ser  Ser Pro Asn 
    1145                 1150                 1155             


Val Ala  Asn Gln Pro Pro Ser  Pro Gly Gly Lys Ser  Ala Tyr Ala 
    1160                 1165                 1170             


Ser Gly  Xaa Xaa Ala Lys Ile  Xaa Ser Val Ser Xaa  Gly Asn Leu 
    1175                 1180                 1185             


Cys Xaa  Glu Glu Gln Xaa Pro  Pro Pro Arg Pro Glu  Ala Tyr Pro 
    1190                 1195                 1200             


Ile Pro  Xaa Gln Xaa Tyr Xaa  Arg Glu Tyr Phe Xaa  Phe Pro Ala 
    1205                 1210                 1215             


Ser Lys  Ser Gln Asp Arg Met  Ala Pro Pro Gln Asn  Gln Trp Pro 
    1220                 1225                 1230             


Asn Tyr  Glu Glu Lys Pro His  Met His Xaa Asp Ser  Asn His Ser 
    1235                 1240                 1245             


Ser Ile  Ala Ile Gln Arg Val  Xaa Arg Ser Gln Glu  Glu Leu Arg 
    1250                 1255                 1260             


Glu Asp  Lys Ala Tyr Gln Leu  Glu Arg His Arg Ile  Glu Ala Ala 
    1265                 1270                 1275             


Met Asp  Arg Lys Ser Asp Ser  Asp Met Trp Ile Asn  Gln Ser Ser 
    1280                 1285                 1290             


Ser Leu  Asp Ser Ser Xaa Ser  Ser Gln Glu His Leu  Asn His Ser 
    1295                 1300                 1305             


Ser Lys  Ser Val Xaa Pro Ala  Ser Xaa Leu Xaa Lys  Ser Gly Pro 
    1310                 1315                 1320             


Gly Arg  Trp Lys Xaa Pro Ala  Ala Ile Pro Ala Xaa  Pro Val Ala 
    1325                 1330                 1335             


Val Ser  Gln Pro Ile Arg Xaa  Asp Leu Pro Pro Pro  Pro Pro Pro 
    1340                 1345                 1350             


Pro Pro  Val His Tyr Ala Gly  Asp Phe Asp Gly Met  Ser Met Asp 
    1355                 1360                 1365             


Leu Pro  Leu Pro Pro Pro Pro  Ser Ala Asn Gln Ile  Gly Leu Pro 
    1370                 1375                 1380             


Ser Ala  Gln Val Ala Ala Ala  Glu Arg Arg Lys Arg  Glu Glu His 
    1385                 1390                 1395             


Gln Arg  Trp Tyr Glu Lys Glu  Lys Ala Arg Leu Glu  Glu Glu Arg 
    1400                 1405                 1410             


Glu Arg  Lys Arg Arg Glu Gln  Glu Arg Lys Leu Gly  Gln Met Arg 
    1415                 1420                 1425             


Xaa Gln  Ser Leu Asn Pro Ala  Pro Phe Ser Pro Leu  Xaa Ala Gln 
    1430                 1435                 1440             


Gln Met  Lys Pro Glu Lys Pro  Ser Xaa Leu Gln Arg  Pro Gln Glu 
    1445                 1450                 1455             


Xaa Val  Ile Arg Glu Leu Gln  Pro Gln Gln Gln Pro  Arg Xaa Ile 
    1460                 1465                 1470             


Glu Arg  Arg Asp Leu Gln Tyr  Ile Xaa Val Ser Lys  Glu Glu Leu 
    1475                 1480                 1485             


Ser Ser  Gly Asp Ser Leu Ser  Pro Asp Pro Trp Lys  Arg Asp Ala 
    1490                 1495                 1500             


Lys Glu  Lys Leu Glu Lys Gln  Gln Gln Met His Ile  Val Asp Met 
    1505                 1510                 1515             


Leu Ser  Lys Glu Ile Gln Glu  Leu Gln Ser Lys Pro  Asp Arg Ser 
    1520                 1525                 1530             


Ala Glu  Glu Ser Asp Arg Leu  Arg Lys Leu Met Leu  Glu Trp Gln 
    1535                 1540                 1545             


Phe Gln  Lys Arg Leu Gln Glu  Ser Lys Gln Lys Asp  Glu Asp Asp 
    1550                 1555                 1560             


Glu Glu  Glu Glu Asp Asp Asp  Val Asp Xaa Met Leu  Ile Met Gln 
    1565                 1570                 1575             


Arg Leu  Glu Ala Glu Arg Arg  Ala Arg Leu Gln Asp  Glu Glu Arg 
    1580                 1585                 1590             


Arg Arg  Gln Gln Gln Leu Glu  Glu Met Arg Lys Arg  Glu Ala Glu 
    1595                 1600                 1605             


Asp Arg  Ala Arg Gln Glu Glu  Glu Arg Arg Arg Gln  Glu Glu Glu 
    1610                 1615                 1620             


Arg Xaa  Lys Arg Asp Ala Glu  Glu Lys Arg Arg Gln  Glu Glu Gly 
    1625                 1630                 1635             


Tyr Tyr  Ser Arg Leu Glu Ala  Glu Arg Arg Arg Gln  His Asp Glu 
    1640                 1645                 1650             


Ala Ala  Arg Arg Leu Leu Glu  Pro Glu Ala Pro Gly  Pro Asn Ser 
    1655                 1660                 1665             


Tyr Pro  Gly Ser Xaa Gly Ala  Ala Val Gly Ala His  Asp Ala Cys 
    1670                 1675                 1680             


Arg Asp  Ala Lys Glu Lys Arg  Ser Lys Ser Gln Asp  Ala Asp Ser 
    1685                 1690                 1695             


Pro Gly  Ser Ser Gly Ala Pro  Glu Asn Leu Xaa Phe  Lys Glu Arg 
    1700                 1705                 1710             


Gln Arg  Leu Phe Ser Gln Gly  Gln Asp Val Ser Asn  Lys Val Lys 
    1715                 1720                 1725             


Ala Ser  Arg Lys Leu Xaa Glu  Leu Glu Asn Glu Leu  Asn Xaa Lys 
    1730                 1735                 1740             


<210> 1882
<211> 1834
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1197)..(1197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1206)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1222)..(1222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1224)..(1224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1226)..(1226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1272)..(1272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1315)..(1315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1344)..(1344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1361)..(1361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1475)..(1475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1488)..(1488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1498)..(1498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1589)..(1589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1604)..(1604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1652)..(1652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1727)..(1727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1737)..(1737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1764)..(1764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1800)..(1800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1825)..(1825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1833)..(1833)
<223> Selenocysteine

<400> 1882
Met Ser Ala Gly Gly Arg Asp Glu Glu Arg Arg Lys Leu Ala Asp Ile 
1               5                   10                  15      


Ile His His Trp Asn Ala Asn Arg Leu Asp Leu Phe Glu Ile Ser Gln 
            20                  25                  30          


Pro Xaa Glu Asp Leu Glu Phe His Gly Val Met Arg Phe Tyr Phe Gln 
        35                  40                  45              


Asp Lys Ala Ala Gly Asn Phe Ala Xaa Lys Cys Ile Arg Val Ser Ser 
    50                  55                  60                  


Xaa Ala Xaa Xaa Gln Asp Val Ile Glu Xaa Leu Ala Glu Lys Phe Arg 
65                  70                  75                  80  


Pro Asp Met Arg Met Leu Ser Ser Pro Lys Tyr Ser Leu Tyr Glu Val 
                85                  90                  95      


His Val Ser Gly Glu Arg Arg Leu Asp Ile Asp Glu Lys Pro Leu Val 
            100                 105                 110         


Val Gln Leu Asn Trp Asn Lys Asp Asp Arg Glu Gly Arg Phe Val Leu 
        115                 120                 125             


Lys Asn Glu Asn Asp Ala Ile Pro Pro Lys Ala Gln Ser Asn Gly Pro 
    130                 135                 140                 


Glu Lys Gln Glu Lys Glu Gly Val Ile Gln Asn Phe Lys Arg Xaa Leu 
145                 150                 155                 160 


Ser Lys Lys Glu Lys Lys Glu Lys Lys Lys Arg Glu Lys Glu Ala Leu 
                165                 170                 175     


Arg Gln Ala Ser Asp Lys Asp Asp Arg Pro Phe Gln Gly Glu Asp Val 
            180                 185                 190         


Glu Asn Ser Arg Leu Ala Ala Glu Val Tyr Lys Asp Met Pro Glu Xaa 
        195                 200                 205             


Ser Phe Xaa Arg Xaa Ile Ser Asn Pro Glu Val Val Met Lys Arg Arg 
    210                 215                 220                 


Arg Gln Gln Lys Leu Glu Lys Arg Met Gln Glu Phe Arg Ser Ser Asp 
225                 230                 235                 240 


Gly Arg Pro Asp Ser Gly Gly Xaa Leu Arg Ile Tyr Ala Asp Ser Leu 
                245                 250                 255     


Lys Pro Asn Ile Pro Tyr Lys Xaa Ile Leu Leu Ser Xaa Xaa Asp Pro 
            260                 265                 270         


Ala Asp Phe Ala Val Ala Glu Ala Leu Glu Lys Tyr Gly Leu Glu Lys 
        275                 280                 285             


Glu Asn Pro Lys Asp Tyr Cys Ile Ala Arg Val Met Leu Pro Pro Gly 
    290                 295                 300                 


Ala Gln His Ser Asp Glu Lys Gly Ala Lys Glu Ile Ile Leu Asp Asp 
305                 310                 315                 320 


Asp Glu Cys Pro Leu Gln Ile Phe Arg Glu Trp Pro Ser Asp Lys Gly 
                325                 330                 335     


Ile Leu Val Phe Gln Leu Lys Arg Arg Pro Pro Asp His Ile Pro Lys 
            340                 345                 350         


Lys Xaa Lys Lys His Leu Glu Gly Lys Xaa Pro Lys Gly Lys Glu Arg 
        355                 360                 365             


Ala Asp Gly Ser Gly Tyr Gly Ser Xaa Leu Pro Pro Glu Lys Leu Pro 
    370                 375                 380                 


Tyr Leu Val Glu Leu Ser Pro Gly Arg Arg Asn His Phe Ala Tyr Tyr 
385                 390                 395                 400 


Asn Tyr His Xaa Tyr Glu Asp Gly Ser Asp Ser Arg Asp Lys Pro Lys 
                405                 410                 415     


Leu Tyr Arg Leu Gln Leu Ser Val Xaa Glu Val Gly Xaa Glu Lys Leu 
            420                 425                 430         


Asp Asp Asn Ser Ile Gln Leu Phe Gly Pro Gly Ile Gln Pro His His 
        435                 440                 445             


Cys Asp Leu Xaa Asn Met Asp Gly Val Val Xaa Val Xaa Pro Arg Ser 
    450                 455                 460                 


Met Asp Ala Glu Xaa Tyr Val Glu Gly Gln Arg Ile Ser Glu Xaa Xaa 
465                 470                 475                 480 


Met Leu Gln Ser Gly Met Lys Val Gln Phe Gly Ala Ser His Val Phe 
                485                 490                 495     


Lys Phe Val Asp Pro Ser Gln Asp His Ala Leu Ala Lys Arg Ser Val 
            500                 505                 510         


Asp Gly Gly Leu Met Val Lys Gly Pro Arg His Lys Pro Gly Ile Val 
        515                 520                 525             


Gln Glu Xaa Xaa Phe Asp Leu Gly Gly Asp Ile His Ser Gly Xaa Ala 
    530                 535                 540                 


Leu Pro Xaa Ser Lys Ser Xaa Xaa Arg Leu Asp Ser Asp Arg Val Ser 
545                 550                 555                 560 


Ser Ala Ser Ser Xaa Ala Glu Arg Gly Met Val Lys Pro Met Ile Arg 
                565                 570                 575     


Val Glu Gln Gln Pro Asp Tyr Arg Arg Gln Glu Ser Arg Xaa Gln Asp 
            580                 585                 590         


Ala Ser Gly Pro Glu Leu Ile Leu Pro Ala Ser Ile Glu Phe Arg Glu 
        595                 600                 605             


Ser Ser Glu Asp Ser Phe Leu Ser Ala Ile Ile Asn Tyr Xaa Asn Ser 
    610                 615                 620                 


Ser Xaa Val His Phe Lys Leu Ser Pro Xaa Tyr Val Leu Tyr Met Ala 
625                 630                 635                 640 


Cys Arg Tyr Val Leu Ser Asn Gln Tyr Arg Pro Asp Ile Ser Pro Xaa 
                645                 650                 655     


Glu Arg Xaa His Lys Val Ile Ala Val Val Asn Lys Met Val Ser Met 
            660                 665                 670         


Met Glu Gly Val Ile Gln Lys Gln Lys Asn Ile Ala Gly Ala Leu Ala 
        675                 680                 685             


Phe Trp Met Ala Asn Ala Ser Glu Leu Leu Asn Phe Ile Lys Gln Asp 
    690                 695                 700                 


Arg Asp Leu Ser Arg Ile Xaa Leu Asp Ala Gln Asp Val Leu Ala His 
705                 710                 715                 720 


Leu Val Gln Met Ala Phe Lys Tyr Leu Val His Cys Leu Gln Ser Glu 
                725                 730                 735     


Leu Asn Asn Tyr Met Pro Ala Phe Leu Asp Asp Pro Glu Glu Asn Ser 
            740                 745                 750         


Leu Gln Arg Pro Lys Ile Asp Asp Val Leu His Xaa Leu Xaa Gly Ala 
        755                 760                 765             


Met Ser Leu Leu Arg Arg Cys Arg Val Asn Ala Ala Leu Xaa Ile Gln 
    770                 775                 780                 


Leu Phe Ser Gln Leu Phe His Phe Ile Asn Met Trp Leu Phe Asn Arg 
785                 790                 795                 800 


Leu Val Xaa Asp Pro Asp Ser Gly Leu Cys Ser His Tyr Trp Gly Ala 
                805                 810                 815     


Ile Ile Arg Gln Gln Leu Gly His Ile Glu Ala Trp Ala Glu Lys Gln 
            820                 825                 830         


Gly Leu Glu Leu Ala Ala Asp Cys His Leu Ser Arg Ile Val Gln Ala 
        835                 840                 845             


Xaa Xaa Leu Leu Xaa Met Asp Lys Tyr Ala Pro Asp Asp Ile Pro Asn 
    850                 855                 860                 


Ile Asn Ser Xaa Cys Phe Lys Leu Asn Ser Leu Gln Leu Gln Ala Leu 
865                 870                 875                 880 


Leu Gln Asn Tyr His Cys Ala Pro Asp Glu Pro Phe Ile Pro Xaa Asp 
                885                 890                 895     


Leu Ile Glu Asn Val Val Xaa Val Ala Glu Asn Xaa Ala Asp Glu Leu 
            900                 905                 910         


Ala Arg Ser Asp Gly Arg Glu Val Gln Leu Glu Glu Asp Pro Asp Leu 
        915                 920                 925             


Gln Leu Pro Phe Leu Leu Pro Glu Asp Gly Tyr Ser Cys Asp Val Val 
    930                 935                 940                 


Arg Asn Ile Pro Asn Gly Leu Gln Glu Phe Leu Asp Pro Leu Cys Gln 
945                 950                 955                 960 


Arg Gly Phe Cys Arg Leu Ile Pro His Xaa Arg Ser Pro Gly Xaa Trp 
                965                 970                 975     


Xaa Ile Tyr Phe Glu Gly Ala Asp Tyr Glu Ser His Leu Leu Arg Glu 
            980                 985                 990         


Asn Xaa Glu Leu Ala Gln Pro Leu  Arg Lys Glu Pro Glu  Ile Ile Xaa 
        995                 1000                 1005             


Val Xaa  Leu Lys Lys Gln Asn  Gly Met Gly Leu Ser  Ile Val Ala 
    1010                 1015                 1020             


Ala Lys  Gly Ala Gly Gln Asp  Lys Leu Gly Ile Tyr  Val Lys Ser 
    1025                 1030                 1035             


Val Val  Lys Gly Gly Ala Ala  Asp Val Asp Gly Arg  Leu Ala Ala 
    1040                 1045                 1050             


Gly Asp  Gln Leu Leu Ser Val  Asp Gly Arg Ser Leu  Val Gly Leu 
    1055                 1060                 1065             


Ser Gln  Glu Arg Ala Ala Glu  Leu Met Xaa Arg Xaa  Ser Ser Val 
    1070                 1075                 1080             


Val Xaa  Leu Glu Val Ala Lys  Gln Gly Ala Ile Tyr  His Gly Leu 
    1085                 1090                 1095             


Ala Xaa  Leu Leu Asn Gln Pro  Ser Pro Met Met Gln  Arg Ile Ser 
    1100                 1105                 1110             


Asp Arg  Arg Gly Ser Gly Lys  Pro Arg Pro Lys Ser  Glu Gly Phe 
    1115                 1120                 1125             


Glu Leu  Tyr Asn Asn Ser Xaa  Gln Asn Gly Ser Pro  Glu Ser Pro 
    1130                 1135                 1140             


Gln Leu  Pro Trp Ala Glu Tyr  Ser Glu Pro Lys Lys  Leu Pro Gly 
    1145                 1150                 1155             


Asp Asp  Arg Leu Met Lys Asn  Arg Ala Asp His Arg  Ser Ser Pro 
    1160                 1165                 1170             


Asn Val  Ala Asn Gln Pro Pro  Ser Pro Gly Gly Lys  Ser Ala Tyr 
    1175                 1180                 1185             


Ala Ser  Gly Xaa Xaa Ala Lys  Ile Xaa Ser Val Ser  Xaa Gly Asn 
    1190                 1195                 1200             


Leu Cys  Xaa Glu Glu Gln Xaa  Pro Pro Pro Arg Pro  Glu Ala Tyr 
    1205                 1210                 1215             


Pro Ile  Pro Xaa Gln Xaa Tyr  Xaa Arg Glu Tyr Phe  Xaa Phe Pro 
    1220                 1225                 1230             


Ala Ser  Lys Ser Gln Asp Arg  Met Ala Pro Pro Gln  Asn Gln Trp 
    1235                 1240                 1245             


Pro Asn  Tyr Glu Glu Lys Pro  His Met His Xaa Asp  Ser Asn His 
    1250                 1255                 1260             


Ser Ser  Ile Ala Ile Gln Arg  Val Xaa Arg Ser Gln  Glu Glu Leu 
    1265                 1270                 1275             


Arg Glu  Asp Lys Ala Tyr Gln  Leu Glu Arg His Arg  Ile Glu Ala 
    1280                 1285                 1290             


Ala Met  Asp Arg Lys Ser Asp  Ser Asp Met Trp Ile  Asn Gln Ser 
    1295                 1300                 1305             


Ser Ser  Leu Asp Ser Ser Xaa  Ser Ser Gln Glu His  Leu Asn His 
    1310                 1315                 1320             


Ser Ser  Lys Ser Val Xaa Pro  Ala Ser Xaa Leu Xaa  Lys Ser Gly 
    1325                 1330                 1335             


Pro Gly  Arg Trp Lys Xaa Pro  Ala Ala Ile Pro Ala  Xaa Pro Val 
    1340                 1345                 1350             


Ala Val  Ser Gln Pro Ile Arg  Xaa Asp Leu Pro Pro  Pro Pro Pro 
    1355                 1360                 1365             


Pro Pro  Pro Val His Tyr Ala  Gly Asp Phe Asp Gly  Met Ser Met 
    1370                 1375                 1380             


Asp Leu  Pro Leu Pro Pro Pro  Pro Ser Ala Asn Gln  Ile Gly Leu 
    1385                 1390                 1395             


Pro Ser  Ala Gln Val Ala Ala  Ala Glu Arg Arg Lys  Arg Glu Glu 
    1400                 1405                 1410             


His Gln  Arg Trp Tyr Glu Lys  Glu Lys Ala Arg Leu  Glu Glu Glu 
    1415                 1420                 1425             


Arg Glu  Arg Lys Arg Arg Glu  Gln Glu Arg Lys Leu  Gly Gln Met 
    1430                 1435                 1440             


Arg Xaa  Gln Ser Leu Asn Pro  Ala Pro Phe Ser Pro  Leu Xaa Ala 
    1445                 1450                 1455             


Gln Gln  Met Lys Pro Glu Lys  Pro Ser Xaa Leu Gln  Arg Pro Gln 
    1460                 1465                 1470             


Glu Xaa  Val Ile Arg Glu Leu  Gln Pro Gln Gln Gln  Pro Arg Xaa 
    1475                 1480                 1485             


Ile Glu  Arg Arg Asp Leu Gln  Tyr Ile Xaa Val Ser  Lys Glu Glu 
    1490                 1495                 1500             


Leu Ser  Ser Gly Asp Ser Leu  Ser Pro Asp Pro Trp  Lys Arg Asp 
    1505                 1510                 1515             


Ala Lys  Glu Lys Leu Glu Lys  Gln Gln Gln Met His  Ile Val Asp 
    1520                 1525                 1530             


Met Leu  Ser Lys Glu Ile Gln  Glu Leu Gln Ser Lys  Pro Asp Arg 
    1535                 1540                 1545             


Ser Ala  Glu Glu Ser Asp Arg  Leu Arg Lys Leu Met  Leu Glu Trp 
    1550                 1555                 1560             


Gln Phe  Gln Lys Arg Leu Gln  Glu Ser Lys Gln Lys  Asp Glu Asp 
    1565                 1570                 1575             


Asp Glu  Glu Glu Glu Asp Asp  Asp Val Asp Xaa Met  Leu Ile Met 
    1580                 1585                 1590             


Gln Arg  Leu Glu Ala Glu Arg  Arg Ala Arg Xaa Ala  Met Pro Ala 
    1595                 1600                 1605             


Ile Ser  Val Leu Asp Leu Leu  Gln Asp Glu Glu Arg  Arg Arg Gln 
    1610                 1615                 1620             


Gln Gln  Leu Glu Glu Met Arg  Lys Arg Glu Ala Glu  Asp Arg Ala 
    1625                 1630                 1635             


Arg Gln  Glu Glu Glu Arg Arg  Arg Gln Glu Glu Glu  Arg Xaa Lys 
    1640                 1645                 1650             


Arg Asp  Ala Glu Glu Lys Arg  Arg Gln Glu Glu Gly  Tyr Tyr Ser 
    1655                 1660                 1665             


Arg Leu  Glu Ala Glu Arg Arg  Arg Gln His Asp Glu  Ala Ala Arg 
    1670                 1675                 1680             


Arg Leu  Leu Glu Pro Glu Ala  Pro Gly Leu Cys Arg  Pro Pro Leu 
    1685                 1690                 1695             


Pro Arg  Asp Tyr Glu Pro Pro  Ser Pro Ser Pro Ala  Pro Gly Ala 
    1700                 1705                 1710             


Pro Pro  Pro Pro Pro Gln Arg  Asn Ala Ser Tyr Leu  Lys Xaa Gln 
    1715                 1720                 1725             


Val Leu  Ser Pro Asp Ser Leu  Phe Xaa Ala Lys Phe  Val Ala Tyr 
    1730                 1735                 1740             


Asn Glu  Glu Glu Glu Glu Glu  Asp Cys Ser Leu Ala  Gly Pro Asn 
    1745                 1750                 1755             


Ser Tyr  Pro Gly Ser Xaa Gly  Ala Ala Val Gly Ala  His Asp Ala 
    1760                 1765                 1770             


Cys Arg  Asp Ala Lys Glu Lys  Arg Ser Lys Ser Gln  Asp Ala Asp 
    1775                 1780                 1785             


Ser Pro  Gly Ser Ser Gly Ala  Pro Glu Asn Leu Xaa  Phe Lys Glu 
    1790                 1795                 1800             


Arg Gln  Arg Leu Phe Ser Gln  Gly Gln Asp Val Ser  Asn Lys Val 
    1805                 1810                 1815             


Lys Ala  Ser Arg Lys Leu Xaa  Glu Leu Glu Asn Glu  Leu Asn Xaa 
    1820                 1825                 1830             


Lys 
    


<210> 1883
<211> 1651
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1193)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1211)..(1211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1260)..(1260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1273)..(1273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1316)..(1316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1330)..(1330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1469)..(1469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1476)..(1476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1489)..(1489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1499)..(1499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1590)..(1590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1640)
<223> Selenocysteine

<400> 1883
Met Ser Ala Gly Gly Arg Asp Glu Glu Arg Arg Lys Leu Ala Asp Ile 
1               5                   10                  15      


Ile His His Trp Asn Ala Asn Arg Leu Asp Leu Phe Glu Ile Ser Gln 
            20                  25                  30          


Pro Xaa Glu Asp Leu Glu Phe His Gly Val Met Arg Phe Tyr Phe Gln 
        35                  40                  45              


Asp Lys Ala Ala Gly Asn Phe Ala Xaa Lys Cys Ile Arg Val Ser Ser 
    50                  55                  60                  


Xaa Ala Xaa Xaa Gln Asp Val Ile Glu Xaa Leu Ala Glu Lys Phe Arg 
65                  70                  75                  80  


Pro Asp Met Arg Met Leu Ser Ser Pro Lys Tyr Ser Leu Tyr Glu Val 
                85                  90                  95      


His Val Ser Gly Glu Arg Arg Leu Asp Ile Asp Glu Lys Pro Leu Val 
            100                 105                 110         


Val Gln Leu Asn Trp Asn Lys Asp Asp Arg Glu Gly Arg Phe Val Leu 
        115                 120                 125             


Lys Asn Glu Asn Asp Ala Ile Pro Pro Lys Lys Ala Gln Ser Asn Gly 
    130                 135                 140                 


Pro Glu Lys Gln Glu Lys Glu Gly Val Ile Gln Asn Phe Lys Arg Xaa 
145                 150                 155                 160 


Leu Ser Lys Lys Glu Lys Lys Glu Lys Lys Lys Arg Glu Lys Glu Ala 
                165                 170                 175     


Leu Arg Gln Ala Ser Asp Lys Asp Asp Arg Pro Phe Gln Gly Glu Asp 
            180                 185                 190         


Val Glu Asn Ser Arg Leu Ala Ala Glu Val Tyr Lys Asp Met Pro Glu 
        195                 200                 205             


Xaa Ser Phe Xaa Arg Xaa Ile Ser Asn Pro Glu Val Val Met Lys Arg 
    210                 215                 220                 


Arg Arg Gln Gln Lys Leu Glu Lys Arg Met Gln Glu Phe Arg Ser Ser 
225                 230                 235                 240 


Asp Gly Arg Pro Asp Ser Gly Gly Xaa Leu Arg Ile Tyr Ala Asp Ser 
                245                 250                 255     


Leu Lys Pro Asn Ile Pro Tyr Lys Xaa Ile Leu Leu Ser Xaa Xaa Asp 
            260                 265                 270         


Pro Ala Asp Phe Ala Val Ala Glu Ala Leu Glu Lys Tyr Gly Leu Glu 
        275                 280                 285             


Lys Glu Asn Pro Lys Asp Tyr Cys Ile Ala Arg Val Met Leu Pro Pro 
    290                 295                 300                 


Gly Ala Gln His Ser Asp Glu Lys Gly Ala Lys Glu Ile Ile Leu Asp 
305                 310                 315                 320 


Asp Asp Glu Cys Pro Leu Gln Ile Phe Arg Glu Trp Pro Ser Asp Lys 
                325                 330                 335     


Gly Ile Leu Val Phe Gln Leu Lys Arg Arg Pro Pro Asp His Ile Pro 
            340                 345                 350         


Lys Lys Xaa Lys Lys His Leu Glu Gly Lys Xaa Pro Lys Gly Lys Glu 
        355                 360                 365             


Arg Ala Asp Gly Ser Gly Tyr Gly Ser Xaa Leu Pro Pro Glu Lys Leu 
    370                 375                 380                 


Pro Tyr Leu Val Glu Leu Ser Pro Gly Arg Arg Asn His Phe Ala Tyr 
385                 390                 395                 400 


Tyr Asn Tyr His Xaa Tyr Glu Asp Gly Ser Asp Ser Arg Asp Lys Pro 
                405                 410                 415     


Lys Leu Tyr Arg Leu Gln Leu Ser Val Xaa Glu Val Gly Xaa Glu Lys 
            420                 425                 430         


Leu Asp Asp Asn Ser Ile Gln Leu Phe Gly Pro Gly Ile Gln Pro His 
        435                 440                 445             


His Cys Asp Leu Xaa Asn Met Asp Gly Val Val Xaa Val Xaa Pro Arg 
    450                 455                 460                 


Ser Met Asp Ala Glu Xaa Tyr Val Glu Gly Gln Arg Ile Ser Glu Xaa 
465                 470                 475                 480 


Xaa Met Leu Gln Ser Gly Met Lys Val Gln Phe Gly Ala Ser His Val 
                485                 490                 495     


Phe Lys Phe Val Asp Pro Ser Gln Asp His Ala Leu Ala Lys Arg Ser 
            500                 505                 510         


Val Asp Gly Gly Leu Met Val Lys Gly Pro Arg His Lys Pro Gly Ile 
        515                 520                 525             


Val Gln Glu Xaa Xaa Phe Asp Leu Gly Gly Asp Ile His Ser Gly Xaa 
    530                 535                 540                 


Ala Leu Pro Xaa Ser Lys Ser Xaa Xaa Arg Leu Asp Ser Asp Arg Val 
545                 550                 555                 560 


Ser Ser Ala Ser Ser Xaa Ala Glu Arg Gly Met Val Lys Pro Met Ile 
                565                 570                 575     


Arg Val Glu Gln Gln Pro Asp Tyr Arg Arg Gln Glu Ser Arg Xaa Gln 
            580                 585                 590         


Asp Ala Ser Gly Pro Glu Leu Ile Leu Pro Ala Ser Ile Glu Phe Arg 
        595                 600                 605             


Glu Ser Ser Glu Asp Ser Phe Leu Ser Ala Ile Ile Asn Tyr Xaa Asn 
    610                 615                 620                 


Ser Ser Xaa Val His Phe Lys Leu Ser Pro Xaa Tyr Val Leu Tyr Met 
625                 630                 635                 640 


Ala Cys Arg Tyr Val Leu Ser Asn Gln Tyr Arg Pro Asp Ile Ser Pro 
                645                 650                 655     


Xaa Glu Arg Xaa His Lys Val Ile Ala Val Val Asn Lys Met Val Ser 
            660                 665                 670         


Met Met Glu Gly Val Ile Gln Lys Gln Lys Asn Ile Ala Gly Ala Leu 
        675                 680                 685             


Ala Phe Trp Met Ala Asn Ala Ser Glu Leu Leu Asn Phe Ile Lys Gln 
    690                 695                 700                 


Asp Arg Asp Leu Ser Arg Ile Xaa Leu Asp Ala Gln Asp Val Leu Ala 
705                 710                 715                 720 


His Leu Val Gln Met Ala Phe Lys Tyr Leu Val His Cys Leu Gln Ser 
                725                 730                 735     


Glu Leu Asn Asn Tyr Met Pro Ala Phe Leu Asp Asp Pro Glu Glu Asn 
            740                 745                 750         


Ser Leu Gln Arg Pro Lys Ile Asp Asp Val Leu His Xaa Leu Xaa Gly 
        755                 760                 765             


Ala Met Ser Leu Leu Arg Arg Cys Arg Val Asn Ala Ala Leu Xaa Ile 
    770                 775                 780                 


Gln Leu Phe Ser Gln Leu Phe His Phe Ile Asn Met Trp Leu Phe Asn 
785                 790                 795                 800 


Arg Leu Val Xaa Asp Pro Asp Ser Gly Leu Cys Ser His Tyr Trp Gly 
                805                 810                 815     


Ala Ile Ile Arg Gln Gln Leu Gly His Ile Glu Ala Trp Ala Glu Lys 
            820                 825                 830         


Gln Gly Leu Glu Leu Ala Ala Asp Cys His Leu Ser Arg Ile Val Gln 
        835                 840                 845             


Ala Xaa Xaa Leu Leu Xaa Met Asp Lys Tyr Ala Pro Asp Asp Ile Pro 
    850                 855                 860                 


Asn Ile Asn Ser Xaa Cys Phe Lys Leu Asn Ser Leu Gln Leu Gln Ala 
865                 870                 875                 880 


Leu Leu Gln Asn Tyr His Cys Ala Pro Asp Glu Pro Phe Ile Pro Xaa 
                885                 890                 895     


Asp Leu Ile Glu Asn Val Val Xaa Val Ala Glu Asn Xaa Ala Asp Glu 
            900                 905                 910         


Leu Ala Arg Ser Asp Gly Arg Glu Val Gln Leu Glu Glu Asp Pro Asp 
        915                 920                 925             


Leu Gln Leu Pro Phe Leu Leu Pro Glu Asp Gly Tyr Ser Cys Asp Val 
    930                 935                 940                 


Val Arg Asn Ile Pro Asn Gly Leu Gln Glu Phe Leu Asp Pro Leu Cys 
945                 950                 955                 960 


Gln Arg Gly Phe Cys Arg Leu Ile Pro His Xaa Arg Ser Pro Gly Xaa 
                965                 970                 975     


Trp Xaa Ile Tyr Phe Glu Gly Ala Asp Tyr Glu Ser His Leu Leu Arg 
            980                 985                 990         


Glu Asn Xaa Glu Leu Ala Gln Pro  Leu Arg Lys Glu Pro  Glu Ile Ile 
        995                 1000                 1005             


Xaa Val  Xaa Leu Lys Lys Gln  Asn Gly Met Gly Leu  Ser Ile Val 
    1010                 1015                 1020             


Ala Ala  Lys Gly Ala Gly Gln  Asp Lys Leu Gly Ile  Tyr Val Lys 
    1025                 1030                 1035             


Ser Val  Val Lys Gly Gly Ala  Ala Asp Val Asp Gly  Arg Leu Ala 
    1040                 1045                 1050             


Ala Gly  Asp Gln Leu Leu Ser  Val Asp Gly Arg Ser  Leu Val Gly 
    1055                 1060                 1065             


Leu Ser  Gln Glu Arg Ala Ala  Glu Leu Met Xaa Arg  Xaa Ser Ser 
    1070                 1075                 1080             


Val Val  Xaa Leu Glu Val Ala  Lys Gln Gly Ala Ile  Tyr His Gly 
    1085                 1090                 1095             


Leu Ala  Xaa Leu Leu Asn Gln  Pro Ser Pro Met Met  Gln Arg Ile 
    1100                 1105                 1110             


Ser Asp  Arg Arg Gly Ser Gly  Lys Pro Arg Pro Lys  Ser Glu Gly 
    1115                 1120                 1125             


Phe Glu  Leu Tyr Asn Asn Ser  Xaa Gln Asn Gly Ser  Pro Glu Ser 
    1130                 1135                 1140             


Pro Gln  Leu Pro Trp Ala Glu  Tyr Ser Glu Pro Lys  Lys Leu Pro 
    1145                 1150                 1155             


Gly Asp  Asp Arg Leu Met Lys  Asn Arg Ala Asp His  Arg Ser Ser 
    1160                 1165                 1170             


Pro Asn  Val Ala Asn Gln Pro  Pro Ser Pro Gly Gly  Lys Ser Ala 
    1175                 1180                 1185             


Tyr Ala  Ser Gly Xaa Xaa Ala  Lys Ile Xaa Ser Val  Ser Xaa Gly 
    1190                 1195                 1200             


Asn Leu  Cys Xaa Glu Glu Gln  Xaa Pro Pro Pro Arg  Pro Glu Ala 
    1205                 1210                 1215             


Tyr Pro  Ile Pro Xaa Gln Xaa  Tyr Xaa Arg Glu Tyr  Phe Xaa Phe 
    1220                 1225                 1230             


Pro Ala  Ser Lys Ser Gln Asp  Arg Met Ala Pro Pro  Gln Asn Gln 
    1235                 1240                 1245             


Trp Pro  Asn Tyr Glu Glu Lys  Pro His Met His Xaa  Asp Ser Asn 
    1250                 1255                 1260             


His Ser  Ser Ile Ala Ile Gln  Arg Val Xaa Arg Ser  Gln Glu Glu 
    1265                 1270                 1275             


Leu Arg  Glu Asp Lys Ala Tyr  Gln Leu Glu Arg His  Arg Ile Glu 
    1280                 1285                 1290             


Ala Ala  Met Asp Arg Lys Ser  Asp Ser Asp Met Trp  Ile Asn Gln 
    1295                 1300                 1305             


Ser Ser  Ser Leu Asp Ser Ser  Xaa Ser Ser Gln Glu  His Leu Asn 
    1310                 1315                 1320             


His Ser  Ser Lys Ser Val Xaa  Pro Ala Ser Xaa Leu  Xaa Lys Ser 
    1325                 1330                 1335             


Gly Pro  Gly Arg Trp Lys Xaa  Pro Ala Ala Ile Pro  Ala Xaa Pro 
    1340                 1345                 1350             


Val Ala  Val Ser Gln Pro Ile  Arg Xaa Asp Leu Pro  Pro Pro Pro 
    1355                 1360                 1365             


Pro Pro  Pro Pro Val His Tyr  Ala Gly Asp Phe Asp  Gly Met Ser 
    1370                 1375                 1380             


Met Asp  Leu Pro Leu Pro Pro  Pro Pro Ser Ala Asn  Gln Ile Gly 
    1385                 1390                 1395             


Leu Pro  Ser Ala Gln Val Ala  Ala Ala Glu Arg Arg  Lys Arg Glu 
    1400                 1405                 1410             


Glu His  Gln Arg Trp Tyr Glu  Lys Glu Lys Ala Arg  Leu Glu Glu 
    1415                 1420                 1425             


Glu Arg  Glu Arg Lys Arg Arg  Glu Gln Glu Arg Lys  Leu Gly Gln 
    1430                 1435                 1440             


Met Arg  Xaa Gln Ser Leu Asn  Pro Ala Pro Phe Ser  Pro Leu Xaa 
    1445                 1450                 1455             


Ala Gln  Gln Met Lys Pro Glu  Lys Pro Ser Xaa Leu  Gln Arg Pro 
    1460                 1465                 1470             


Gln Glu  Xaa Val Ile Arg Glu  Leu Gln Pro Gln Gln  Gln Pro Arg 
    1475                 1480                 1485             


Xaa Ile  Glu Arg Arg Asp Leu  Gln Tyr Ile Xaa Val  Ser Lys Glu 
    1490                 1495                 1500             


Glu Leu  Ser Ser Gly Asp Ser  Leu Ser Pro Asp Pro  Trp Lys Arg 
    1505                 1510                 1515             


Asp Ala  Lys Glu Lys Leu Glu  Lys Gln Gln Gln Met  His Ile Val 
    1520                 1525                 1530             


Asp Met  Leu Ser Lys Glu Ile  Gln Glu Leu Gln Ser  Lys Pro Asp 
    1535                 1540                 1545             


Arg Ser  Ala Glu Glu Ser Asp  Arg Leu Arg Lys Leu  Met Leu Glu 
    1550                 1555                 1560             


Trp Gln  Phe Gln Lys Arg Leu  Gln Glu Ser Lys Gln  Lys Asp Glu 
    1565                 1570                 1575             


Asp Asp  Glu Glu Glu Glu Asp  Asp Asp Val Asp Xaa  Met Leu Ile 
    1580                 1585                 1590             


Met Gln  Arg Leu Glu Ala Glu  Arg Arg Ala Arg Asp  Glu Glu Arg 
    1595                 1600                 1605             


Arg Arg  Gln Gln Gln Leu Glu  Glu Met Arg Lys Arg  Glu Ala Glu 
    1610                 1615                 1620             


Asp Arg  Ala Arg Gln Glu Glu  Glu Arg Arg Arg Gln  Glu Glu Glu 
    1625                 1630                 1635             


Arg Xaa  Lys Arg Asp Ala Glu  Glu Lys Val Met Val  Leu 
    1640                 1645                 1650     


<210> 1884
<211> 1665
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1193)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1211)..(1211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1260)..(1260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1273)..(1273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1316)..(1316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1330)..(1330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1469)..(1469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1476)..(1476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1489)..(1489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1499)..(1499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1590)..(1590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1654)..(1654)
<223> Selenocysteine

<400> 1884
Met Ser Ala Gly Gly Arg Asp Glu Glu Arg Arg Lys Leu Ala Asp Ile 
1               5                   10                  15      


Ile His His Trp Asn Ala Asn Arg Leu Asp Leu Phe Glu Ile Ser Gln 
            20                  25                  30          


Pro Xaa Glu Asp Leu Glu Phe His Gly Val Met Arg Phe Tyr Phe Gln 
        35                  40                  45              


Asp Lys Ala Ala Gly Asn Phe Ala Xaa Lys Cys Ile Arg Val Ser Ser 
    50                  55                  60                  


Xaa Ala Xaa Xaa Gln Asp Val Ile Glu Xaa Leu Ala Glu Lys Phe Arg 
65                  70                  75                  80  


Pro Asp Met Arg Met Leu Ser Ser Pro Lys Tyr Ser Leu Tyr Glu Val 
                85                  90                  95      


His Val Ser Gly Glu Arg Arg Leu Asp Ile Asp Glu Lys Pro Leu Val 
            100                 105                 110         


Val Gln Leu Asn Trp Asn Lys Asp Asp Arg Glu Gly Arg Phe Val Leu 
        115                 120                 125             


Lys Asn Glu Asn Asp Ala Ile Pro Pro Lys Lys Ala Gln Ser Asn Gly 
    130                 135                 140                 


Pro Glu Lys Gln Glu Lys Glu Gly Val Ile Gln Asn Phe Lys Arg Xaa 
145                 150                 155                 160 


Leu Ser Lys Lys Glu Lys Lys Glu Lys Lys Lys Arg Glu Lys Glu Ala 
                165                 170                 175     


Leu Arg Gln Ala Ser Asp Lys Asp Asp Arg Pro Phe Gln Gly Glu Asp 
            180                 185                 190         


Val Glu Asn Ser Arg Leu Ala Ala Glu Val Tyr Lys Asp Met Pro Glu 
        195                 200                 205             


Xaa Ser Phe Xaa Arg Xaa Ile Ser Asn Pro Glu Val Val Met Lys Arg 
    210                 215                 220                 


Arg Arg Gln Gln Lys Leu Glu Lys Arg Met Gln Glu Phe Arg Ser Ser 
225                 230                 235                 240 


Asp Gly Arg Pro Asp Ser Gly Gly Xaa Leu Arg Ile Tyr Ala Asp Ser 
                245                 250                 255     


Leu Lys Pro Asn Ile Pro Tyr Lys Xaa Ile Leu Leu Ser Xaa Xaa Asp 
            260                 265                 270         


Pro Ala Asp Phe Ala Val Ala Glu Ala Leu Glu Lys Tyr Gly Leu Glu 
        275                 280                 285             


Lys Glu Asn Pro Lys Asp Tyr Cys Ile Ala Arg Val Met Leu Pro Pro 
    290                 295                 300                 


Gly Ala Gln His Ser Asp Glu Lys Gly Ala Lys Glu Ile Ile Leu Asp 
305                 310                 315                 320 


Asp Asp Glu Cys Pro Leu Gln Ile Phe Arg Glu Trp Pro Ser Asp Lys 
                325                 330                 335     


Gly Ile Leu Val Phe Gln Leu Lys Arg Arg Pro Pro Asp His Ile Pro 
            340                 345                 350         


Lys Lys Xaa Lys Lys His Leu Glu Gly Lys Xaa Pro Lys Gly Lys Glu 
        355                 360                 365             


Arg Ala Asp Gly Ser Gly Tyr Gly Ser Xaa Leu Pro Pro Glu Lys Leu 
    370                 375                 380                 


Pro Tyr Leu Val Glu Leu Ser Pro Gly Arg Arg Asn His Phe Ala Tyr 
385                 390                 395                 400 


Tyr Asn Tyr His Xaa Tyr Glu Asp Gly Ser Asp Ser Arg Asp Lys Pro 
                405                 410                 415     


Lys Leu Tyr Arg Leu Gln Leu Ser Val Xaa Glu Val Gly Xaa Glu Lys 
            420                 425                 430         


Leu Asp Asp Asn Ser Ile Gln Leu Phe Gly Pro Gly Ile Gln Pro His 
        435                 440                 445             


His Cys Asp Leu Xaa Asn Met Asp Gly Val Val Xaa Val Xaa Pro Arg 
    450                 455                 460                 


Ser Met Asp Ala Glu Xaa Tyr Val Glu Gly Gln Arg Ile Ser Glu Xaa 
465                 470                 475                 480 


Xaa Met Leu Gln Ser Gly Met Lys Val Gln Phe Gly Ala Ser His Val 
                485                 490                 495     


Phe Lys Phe Val Asp Pro Ser Gln Asp His Ala Leu Ala Lys Arg Ser 
            500                 505                 510         


Val Asp Gly Gly Leu Met Val Lys Gly Pro Arg His Lys Pro Gly Ile 
        515                 520                 525             


Val Gln Glu Xaa Xaa Phe Asp Leu Gly Gly Asp Ile His Ser Gly Xaa 
    530                 535                 540                 


Ala Leu Pro Xaa Ser Lys Ser Xaa Xaa Arg Leu Asp Ser Asp Arg Val 
545                 550                 555                 560 


Ser Ser Ala Ser Ser Xaa Ala Glu Arg Gly Met Val Lys Pro Met Ile 
                565                 570                 575     


Arg Val Glu Gln Gln Pro Asp Tyr Arg Arg Gln Glu Ser Arg Xaa Gln 
            580                 585                 590         


Asp Ala Ser Gly Pro Glu Leu Ile Leu Pro Ala Ser Ile Glu Phe Arg 
        595                 600                 605             


Glu Ser Ser Glu Asp Ser Phe Leu Ser Ala Ile Ile Asn Tyr Xaa Asn 
    610                 615                 620                 


Ser Ser Xaa Val His Phe Lys Leu Ser Pro Xaa Tyr Val Leu Tyr Met 
625                 630                 635                 640 


Ala Cys Arg Tyr Val Leu Ser Asn Gln Tyr Arg Pro Asp Ile Ser Pro 
                645                 650                 655     


Xaa Glu Arg Xaa His Lys Val Ile Ala Val Val Asn Lys Met Val Ser 
            660                 665                 670         


Met Met Glu Gly Val Ile Gln Lys Gln Lys Asn Ile Ala Gly Ala Leu 
        675                 680                 685             


Ala Phe Trp Met Ala Asn Ala Ser Glu Leu Leu Asn Phe Ile Lys Gln 
    690                 695                 700                 


Asp Arg Asp Leu Ser Arg Ile Xaa Leu Asp Ala Gln Asp Val Leu Ala 
705                 710                 715                 720 


His Leu Val Gln Met Ala Phe Lys Tyr Leu Val His Cys Leu Gln Ser 
                725                 730                 735     


Glu Leu Asn Asn Tyr Met Pro Ala Phe Leu Asp Asp Pro Glu Glu Asn 
            740                 745                 750         


Ser Leu Gln Arg Pro Lys Ile Asp Asp Val Leu His Xaa Leu Xaa Gly 
        755                 760                 765             


Ala Met Ser Leu Leu Arg Arg Cys Arg Val Asn Ala Ala Leu Xaa Ile 
    770                 775                 780                 


Gln Leu Phe Ser Gln Leu Phe His Phe Ile Asn Met Trp Leu Phe Asn 
785                 790                 795                 800 


Arg Leu Val Xaa Asp Pro Asp Ser Gly Leu Cys Ser His Tyr Trp Gly 
                805                 810                 815     


Ala Ile Ile Arg Gln Gln Leu Gly His Ile Glu Ala Trp Ala Glu Lys 
            820                 825                 830         


Gln Gly Leu Glu Leu Ala Ala Asp Cys His Leu Ser Arg Ile Val Gln 
        835                 840                 845             


Ala Xaa Xaa Leu Leu Xaa Met Asp Lys Tyr Ala Pro Asp Asp Ile Pro 
    850                 855                 860                 


Asn Ile Asn Ser Xaa Cys Phe Lys Leu Asn Ser Leu Gln Leu Gln Ala 
865                 870                 875                 880 


Leu Leu Gln Asn Tyr His Cys Ala Pro Asp Glu Pro Phe Ile Pro Xaa 
                885                 890                 895     


Asp Leu Ile Glu Asn Val Val Xaa Val Ala Glu Asn Xaa Ala Asp Glu 
            900                 905                 910         


Leu Ala Arg Ser Asp Gly Arg Glu Val Gln Leu Glu Glu Asp Pro Asp 
        915                 920                 925             


Leu Gln Leu Pro Phe Leu Leu Pro Glu Asp Gly Tyr Ser Cys Asp Val 
    930                 935                 940                 


Val Arg Asn Ile Pro Asn Gly Leu Gln Glu Phe Leu Asp Pro Leu Cys 
945                 950                 955                 960 


Gln Arg Gly Phe Cys Arg Leu Ile Pro His Xaa Arg Ser Pro Gly Xaa 
                965                 970                 975     


Trp Xaa Ile Tyr Phe Glu Gly Ala Asp Tyr Glu Ser His Leu Leu Arg 
            980                 985                 990         


Glu Asn Xaa Glu Leu Ala Gln Pro  Leu Arg Lys Glu Pro  Glu Ile Ile 
        995                 1000                 1005             


Xaa Val  Xaa Leu Lys Lys Gln  Asn Gly Met Gly Leu  Ser Ile Val 
    1010                 1015                 1020             


Ala Ala  Lys Gly Ala Gly Gln  Asp Lys Leu Gly Ile  Tyr Val Lys 
    1025                 1030                 1035             


Ser Val  Val Lys Gly Gly Ala  Ala Asp Val Asp Gly  Arg Leu Ala 
    1040                 1045                 1050             


Ala Gly  Asp Gln Leu Leu Ser  Val Asp Gly Arg Ser  Leu Val Gly 
    1055                 1060                 1065             


Leu Ser  Gln Glu Arg Ala Ala  Glu Leu Met Xaa Arg  Xaa Ser Ser 
    1070                 1075                 1080             


Val Val  Xaa Leu Glu Val Ala  Lys Gln Gly Ala Ile  Tyr His Gly 
    1085                 1090                 1095             


Leu Ala  Xaa Leu Leu Asn Gln  Pro Ser Pro Met Met  Gln Arg Ile 
    1100                 1105                 1110             


Ser Asp  Arg Arg Gly Ser Gly  Lys Pro Arg Pro Lys  Ser Glu Gly 
    1115                 1120                 1125             


Phe Glu  Leu Tyr Asn Asn Ser  Xaa Gln Asn Gly Ser  Pro Glu Ser 
    1130                 1135                 1140             


Pro Gln  Leu Pro Trp Ala Glu  Tyr Ser Glu Pro Lys  Lys Leu Pro 
    1145                 1150                 1155             


Gly Asp  Asp Arg Leu Met Lys  Asn Arg Ala Asp His  Arg Ser Ser 
    1160                 1165                 1170             


Pro Asn  Val Ala Asn Gln Pro  Pro Ser Pro Gly Gly  Lys Ser Ala 
    1175                 1180                 1185             


Tyr Ala  Ser Gly Xaa Xaa Ala  Lys Ile Xaa Ser Val  Ser Xaa Gly 
    1190                 1195                 1200             


Asn Leu  Cys Xaa Glu Glu Gln  Xaa Pro Pro Pro Arg  Pro Glu Ala 
    1205                 1210                 1215             


Tyr Pro  Ile Pro Xaa Gln Xaa  Tyr Xaa Arg Glu Tyr  Phe Xaa Phe 
    1220                 1225                 1230             


Pro Ala  Ser Lys Ser Gln Asp  Arg Met Ala Pro Pro  Gln Asn Gln 
    1235                 1240                 1245             


Trp Pro  Asn Tyr Glu Glu Lys  Pro His Met His Xaa  Asp Ser Asn 
    1250                 1255                 1260             


His Ser  Ser Ile Ala Ile Gln  Arg Val Xaa Arg Ser  Gln Glu Glu 
    1265                 1270                 1275             


Leu Arg  Glu Asp Lys Ala Tyr  Gln Leu Glu Arg His  Arg Ile Glu 
    1280                 1285                 1290             


Ala Ala  Met Asp Arg Lys Ser  Asp Ser Asp Met Trp  Ile Asn Gln 
    1295                 1300                 1305             


Ser Ser  Ser Leu Asp Ser Ser  Xaa Ser Ser Gln Glu  His Leu Asn 
    1310                 1315                 1320             


His Ser  Ser Lys Ser Val Xaa  Pro Ala Ser Xaa Leu  Xaa Lys Ser 
    1325                 1330                 1335             


Gly Pro  Gly Arg Trp Lys Xaa  Pro Ala Ala Ile Pro  Ala Xaa Pro 
    1340                 1345                 1350             


Val Ala  Val Ser Gln Pro Ile  Arg Xaa Asp Leu Pro  Pro Pro Pro 
    1355                 1360                 1365             


Pro Pro  Pro Pro Val His Tyr  Ala Gly Asp Phe Asp  Gly Met Ser 
    1370                 1375                 1380             


Met Asp  Leu Pro Leu Pro Pro  Pro Pro Ser Ala Asn  Gln Ile Gly 
    1385                 1390                 1395             


Leu Pro  Ser Ala Gln Val Ala  Ala Ala Glu Arg Arg  Lys Arg Glu 
    1400                 1405                 1410             


Glu His  Gln Arg Trp Tyr Glu  Lys Glu Lys Ala Arg  Leu Glu Glu 
    1415                 1420                 1425             


Glu Arg  Glu Arg Lys Arg Arg  Glu Gln Glu Arg Lys  Leu Gly Gln 
    1430                 1435                 1440             


Met Arg  Xaa Gln Ser Leu Asn  Pro Ala Pro Phe Ser  Pro Leu Xaa 
    1445                 1450                 1455             


Ala Gln  Gln Met Lys Pro Glu  Lys Pro Ser Xaa Leu  Gln Arg Pro 
    1460                 1465                 1470             


Gln Glu  Xaa Val Ile Arg Glu  Leu Gln Pro Gln Gln  Gln Pro Arg 
    1475                 1480                 1485             


Xaa Ile  Glu Arg Arg Asp Leu  Gln Tyr Ile Xaa Val  Ser Lys Glu 
    1490                 1495                 1500             


Glu Leu  Ser Ser Gly Asp Ser  Leu Ser Pro Asp Pro  Trp Lys Arg 
    1505                 1510                 1515             


Asp Ala  Lys Glu Lys Leu Glu  Lys Gln Gln Gln Met  His Ile Val 
    1520                 1525                 1530             


Asp Met  Leu Ser Lys Glu Ile  Gln Glu Leu Gln Ser  Lys Pro Asp 
    1535                 1540                 1545             


Arg Ser  Ala Glu Glu Ser Asp  Arg Leu Arg Lys Leu  Met Leu Glu 
    1550                 1555                 1560             


Trp Gln  Phe Gln Lys Arg Leu  Gln Glu Ser Lys Gln  Lys Asp Glu 
    1565                 1570                 1575             


Asp Asp  Glu Glu Glu Glu Asp  Asp Asp Val Asp Xaa  Met Leu Ile 
    1580                 1585                 1590             


Met Gln  Arg Leu Glu Ala Glu  Arg Arg Ala Arg Gln  Xaa Ala Met 
    1595                 1600                 1605             


Pro Ala  Ile Ser Val Leu Asp  Leu Leu Gln Asp Glu  Glu Arg Arg 
    1610                 1615                 1620             


Arg Gln  Gln Gln Leu Glu Glu  Met Arg Lys Arg Glu  Ala Glu Asp 
    1625                 1630                 1635             


Arg Ala  Arg Gln Glu Glu Glu  Arg Arg Arg Gln Glu  Glu Glu Arg 
    1640                 1645                 1650             


Xaa Lys  Arg Asp Ala Glu Glu  Lys Val Met Val Leu  
    1655                 1660                 1665 


<210> 1885
<211> 1824
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1193)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1211)..(1211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1260)..(1260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1273)..(1273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1316)..(1316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1330)..(1330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1469)..(1469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1476)..(1476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1489)..(1489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1499)..(1499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1590)..(1590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1642)..(1642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1717)..(1717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1727)..(1727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1815)..(1815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1823)..(1823)
<223> Selenocysteine

<400> 1885
Met Ser Ala Gly Gly Arg Asp Glu Glu Arg Arg Lys Leu Ala Asp Ile 
1               5                   10                  15      


Ile His His Trp Asn Ala Asn Arg Leu Asp Leu Phe Glu Ile Ser Gln 
            20                  25                  30          


Pro Xaa Glu Asp Leu Glu Phe His Gly Val Met Arg Phe Tyr Phe Gln 
        35                  40                  45              


Asp Lys Ala Ala Gly Asn Phe Ala Xaa Lys Cys Ile Arg Val Ser Ser 
    50                  55                  60                  


Xaa Ala Xaa Xaa Gln Asp Val Ile Glu Xaa Leu Ala Glu Lys Phe Arg 
65                  70                  75                  80  


Pro Asp Met Arg Met Leu Ser Ser Pro Lys Tyr Ser Leu Tyr Glu Val 
                85                  90                  95      


His Val Ser Gly Glu Arg Arg Leu Asp Ile Asp Glu Lys Pro Leu Val 
            100                 105                 110         


Val Gln Leu Asn Trp Asn Lys Asp Asp Arg Glu Gly Arg Phe Val Leu 
        115                 120                 125             


Lys Asn Glu Asn Asp Ala Ile Pro Pro Lys Lys Ala Gln Ser Asn Gly 
    130                 135                 140                 


Pro Glu Lys Gln Glu Lys Glu Gly Val Ile Gln Asn Phe Lys Arg Xaa 
145                 150                 155                 160 


Leu Ser Lys Lys Glu Lys Lys Glu Lys Lys Lys Arg Glu Lys Glu Ala 
                165                 170                 175     


Leu Arg Gln Ala Ser Asp Lys Asp Asp Arg Pro Phe Gln Gly Glu Asp 
            180                 185                 190         


Val Glu Asn Ser Arg Leu Ala Ala Glu Val Tyr Lys Asp Met Pro Glu 
        195                 200                 205             


Xaa Ser Phe Xaa Arg Xaa Ile Ser Asn Pro Glu Val Val Met Lys Arg 
    210                 215                 220                 


Arg Arg Gln Gln Lys Leu Glu Lys Arg Met Gln Glu Phe Arg Ser Ser 
225                 230                 235                 240 


Asp Gly Arg Pro Asp Ser Gly Gly Xaa Leu Arg Ile Tyr Ala Asp Ser 
                245                 250                 255     


Leu Lys Pro Asn Ile Pro Tyr Lys Xaa Ile Leu Leu Ser Xaa Xaa Asp 
            260                 265                 270         


Pro Ala Asp Phe Ala Val Ala Glu Ala Leu Glu Lys Tyr Gly Leu Glu 
        275                 280                 285             


Lys Glu Asn Pro Lys Asp Tyr Cys Ile Ala Arg Val Met Leu Pro Pro 
    290                 295                 300                 


Gly Ala Gln His Ser Asp Glu Lys Gly Ala Lys Glu Ile Ile Leu Asp 
305                 310                 315                 320 


Asp Asp Glu Cys Pro Leu Gln Ile Phe Arg Glu Trp Pro Ser Asp Lys 
                325                 330                 335     


Gly Ile Leu Val Phe Gln Leu Lys Arg Arg Pro Pro Asp His Ile Pro 
            340                 345                 350         


Lys Lys Xaa Lys Lys His Leu Glu Gly Lys Xaa Pro Lys Gly Lys Glu 
        355                 360                 365             


Arg Ala Asp Gly Ser Gly Tyr Gly Ser Xaa Leu Pro Pro Glu Lys Leu 
    370                 375                 380                 


Pro Tyr Leu Val Glu Leu Ser Pro Gly Arg Arg Asn His Phe Ala Tyr 
385                 390                 395                 400 


Tyr Asn Tyr His Xaa Tyr Glu Asp Gly Ser Asp Ser Arg Asp Lys Pro 
                405                 410                 415     


Lys Leu Tyr Arg Leu Gln Leu Ser Val Xaa Glu Val Gly Xaa Glu Lys 
            420                 425                 430         


Leu Asp Asp Asn Ser Ile Gln Leu Phe Gly Pro Gly Ile Gln Pro His 
        435                 440                 445             


His Cys Asp Leu Xaa Asn Met Asp Gly Val Val Xaa Val Xaa Pro Arg 
    450                 455                 460                 


Ser Met Asp Ala Glu Xaa Tyr Val Glu Gly Gln Arg Ile Ser Glu Xaa 
465                 470                 475                 480 


Xaa Met Leu Gln Ser Gly Met Lys Val Gln Phe Gly Ala Ser His Val 
                485                 490                 495     


Phe Lys Phe Val Asp Pro Ser Gln Asp His Ala Leu Ala Lys Arg Ser 
            500                 505                 510         


Val Asp Gly Gly Leu Met Val Lys Gly Pro Arg His Lys Pro Gly Ile 
        515                 520                 525             


Val Gln Glu Xaa Xaa Phe Asp Leu Gly Gly Asp Ile His Ser Gly Xaa 
    530                 535                 540                 


Ala Leu Pro Xaa Ser Lys Ser Xaa Xaa Arg Leu Asp Ser Asp Arg Val 
545                 550                 555                 560 


Ser Ser Ala Ser Ser Xaa Ala Glu Arg Gly Met Val Lys Pro Met Ile 
                565                 570                 575     


Arg Val Glu Gln Gln Pro Asp Tyr Arg Arg Gln Glu Ser Arg Xaa Gln 
            580                 585                 590         


Asp Ala Ser Gly Pro Glu Leu Ile Leu Pro Ala Ser Ile Glu Phe Arg 
        595                 600                 605             


Glu Ser Ser Glu Asp Ser Phe Leu Ser Ala Ile Ile Asn Tyr Xaa Asn 
    610                 615                 620                 


Ser Ser Xaa Val His Phe Lys Leu Ser Pro Xaa Tyr Val Leu Tyr Met 
625                 630                 635                 640 


Ala Cys Arg Tyr Val Leu Ser Asn Gln Tyr Arg Pro Asp Ile Ser Pro 
                645                 650                 655     


Xaa Glu Arg Xaa His Lys Val Ile Ala Val Val Asn Lys Met Val Ser 
            660                 665                 670         


Met Met Glu Gly Val Ile Gln Lys Gln Lys Asn Ile Ala Gly Ala Leu 
        675                 680                 685             


Ala Phe Trp Met Ala Asn Ala Ser Glu Leu Leu Asn Phe Ile Lys Gln 
    690                 695                 700                 


Asp Arg Asp Leu Ser Arg Ile Xaa Leu Asp Ala Gln Asp Val Leu Ala 
705                 710                 715                 720 


His Leu Val Gln Met Ala Phe Lys Tyr Leu Val His Cys Leu Gln Ser 
                725                 730                 735     


Glu Leu Asn Asn Tyr Met Pro Ala Phe Leu Asp Asp Pro Glu Glu Asn 
            740                 745                 750         


Ser Leu Gln Arg Pro Lys Ile Asp Asp Val Leu His Xaa Leu Xaa Gly 
        755                 760                 765             


Ala Met Ser Leu Leu Arg Arg Cys Arg Val Asn Ala Ala Leu Xaa Ile 
    770                 775                 780                 


Gln Leu Phe Ser Gln Leu Phe His Phe Ile Asn Met Trp Leu Phe Asn 
785                 790                 795                 800 


Arg Leu Val Xaa Asp Pro Asp Ser Gly Leu Cys Ser His Tyr Trp Gly 
                805                 810                 815     


Ala Ile Ile Arg Gln Gln Leu Gly His Ile Glu Ala Trp Ala Glu Lys 
            820                 825                 830         


Gln Gly Leu Glu Leu Ala Ala Asp Cys His Leu Ser Arg Ile Val Gln 
        835                 840                 845             


Ala Xaa Xaa Leu Leu Xaa Met Asp Lys Tyr Ala Pro Asp Asp Ile Pro 
    850                 855                 860                 


Asn Ile Asn Ser Xaa Cys Phe Lys Leu Asn Ser Leu Gln Leu Gln Ala 
865                 870                 875                 880 


Leu Leu Gln Asn Tyr His Cys Ala Pro Asp Glu Pro Phe Ile Pro Xaa 
                885                 890                 895     


Asp Leu Ile Glu Asn Val Val Xaa Val Ala Glu Asn Xaa Ala Asp Glu 
            900                 905                 910         


Leu Ala Arg Ser Asp Gly Arg Glu Val Gln Leu Glu Glu Asp Pro Asp 
        915                 920                 925             


Leu Gln Leu Pro Phe Leu Leu Pro Glu Asp Gly Tyr Ser Cys Asp Val 
    930                 935                 940                 


Val Arg Asn Ile Pro Asn Gly Leu Gln Glu Phe Leu Asp Pro Leu Cys 
945                 950                 955                 960 


Gln Arg Gly Phe Cys Arg Leu Ile Pro His Xaa Arg Ser Pro Gly Xaa 
                965                 970                 975     


Trp Xaa Ile Tyr Phe Glu Gly Ala Asp Tyr Glu Ser His Leu Leu Arg 
            980                 985                 990         


Glu Asn Xaa Glu Leu Ala Gln Pro  Leu Arg Lys Glu Pro  Glu Ile Ile 
        995                 1000                 1005             


Xaa Val  Xaa Leu Lys Lys Gln  Asn Gly Met Gly Leu  Ser Ile Val 
    1010                 1015                 1020             


Ala Ala  Lys Gly Ala Gly Gln  Asp Lys Leu Gly Ile  Tyr Val Lys 
    1025                 1030                 1035             


Ser Val  Val Lys Gly Gly Ala  Ala Asp Val Asp Gly  Arg Leu Ala 
    1040                 1045                 1050             


Ala Gly  Asp Gln Leu Leu Ser  Val Asp Gly Arg Ser  Leu Val Gly 
    1055                 1060                 1065             


Leu Ser  Gln Glu Arg Ala Ala  Glu Leu Met Xaa Arg  Xaa Ser Ser 
    1070                 1075                 1080             


Val Val  Xaa Leu Glu Val Ala  Lys Gln Gly Ala Ile  Tyr His Gly 
    1085                 1090                 1095             


Leu Ala  Xaa Leu Leu Asn Gln  Pro Ser Pro Met Met  Gln Arg Ile 
    1100                 1105                 1110             


Ser Asp  Arg Arg Gly Ser Gly  Lys Pro Arg Pro Lys  Ser Glu Gly 
    1115                 1120                 1125             


Phe Glu  Leu Tyr Asn Asn Ser  Xaa Gln Asn Gly Ser  Pro Glu Ser 
    1130                 1135                 1140             


Pro Gln  Leu Pro Trp Ala Glu  Tyr Ser Glu Pro Lys  Lys Leu Pro 
    1145                 1150                 1155             


Gly Asp  Asp Arg Leu Met Lys  Asn Arg Ala Asp His  Arg Ser Ser 
    1160                 1165                 1170             


Pro Asn  Val Ala Asn Gln Pro  Pro Ser Pro Gly Gly  Lys Ser Ala 
    1175                 1180                 1185             


Tyr Ala  Ser Gly Xaa Xaa Ala  Lys Ile Xaa Ser Val  Ser Xaa Gly 
    1190                 1195                 1200             


Asn Leu  Cys Xaa Glu Glu Gln  Xaa Pro Pro Pro Arg  Pro Glu Ala 
    1205                 1210                 1215             


Tyr Pro  Ile Pro Xaa Gln Xaa  Tyr Xaa Arg Glu Tyr  Phe Xaa Phe 
    1220                 1225                 1230             


Pro Ala  Ser Lys Ser Gln Asp  Arg Met Ala Pro Pro  Gln Asn Gln 
    1235                 1240                 1245             


Trp Pro  Asn Tyr Glu Glu Lys  Pro His Met His Xaa  Asp Ser Asn 
    1250                 1255                 1260             


His Ser  Ser Ile Ala Ile Gln  Arg Val Xaa Arg Ser  Gln Glu Glu 
    1265                 1270                 1275             


Leu Arg  Glu Asp Lys Ala Tyr  Gln Leu Glu Arg His  Arg Ile Glu 
    1280                 1285                 1290             


Ala Ala  Met Asp Arg Lys Ser  Asp Ser Asp Met Trp  Ile Asn Gln 
    1295                 1300                 1305             


Ser Ser  Ser Leu Asp Ser Ser  Xaa Ser Ser Gln Glu  His Leu Asn 
    1310                 1315                 1320             


His Ser  Ser Lys Ser Val Xaa  Pro Ala Ser Xaa Leu  Xaa Lys Ser 
    1325                 1330                 1335             


Gly Pro  Gly Arg Trp Lys Xaa  Pro Ala Ala Ile Pro  Ala Xaa Pro 
    1340                 1345                 1350             


Val Ala  Val Ser Gln Pro Ile  Arg Xaa Asp Leu Pro  Pro Pro Pro 
    1355                 1360                 1365             


Pro Pro  Pro Pro Val His Tyr  Ala Gly Asp Phe Asp  Gly Met Ser 
    1370                 1375                 1380             


Met Asp  Leu Pro Leu Pro Pro  Pro Pro Ser Ala Asn  Gln Ile Gly 
    1385                 1390                 1395             


Leu Pro  Ser Ala Gln Val Ala  Ala Ala Glu Arg Arg  Lys Arg Glu 
    1400                 1405                 1410             


Glu His  Gln Arg Trp Tyr Glu  Lys Glu Lys Ala Arg  Leu Glu Glu 
    1415                 1420                 1425             


Glu Arg  Glu Arg Lys Arg Arg  Glu Gln Glu Arg Lys  Leu Gly Gln 
    1430                 1435                 1440             


Met Arg  Xaa Gln Ser Leu Asn  Pro Ala Pro Phe Ser  Pro Leu Xaa 
    1445                 1450                 1455             


Ala Gln  Gln Met Lys Pro Glu  Lys Pro Ser Xaa Leu  Gln Arg Pro 
    1460                 1465                 1470             


Gln Glu  Xaa Val Ile Arg Glu  Leu Gln Pro Gln Gln  Gln Pro Arg 
    1475                 1480                 1485             


Xaa Ile  Glu Arg Arg Asp Leu  Gln Tyr Ile Xaa Val  Ser Lys Glu 
    1490                 1495                 1500             


Glu Leu  Ser Ser Gly Asp Ser  Leu Ser Pro Asp Pro  Trp Lys Arg 
    1505                 1510                 1515             


Asp Ala  Lys Glu Lys Leu Glu  Lys Gln Gln Gln Met  His Ile Val 
    1520                 1525                 1530             


Asp Met  Leu Ser Lys Glu Ile  Gln Glu Leu Gln Ser  Lys Pro Asp 
    1535                 1540                 1545             


Arg Ser  Ala Glu Glu Ser Asp  Arg Leu Arg Lys Leu  Met Leu Glu 
    1550                 1555                 1560             


Trp Gln  Phe Gln Lys Arg Leu  Gln Glu Ser Lys Gln  Lys Asp Glu 
    1565                 1570                 1575             


Asp Asp  Glu Glu Glu Glu Asp  Asp Asp Val Asp Xaa  Met Leu Ile 
    1580                 1585                 1590             


Met Gln  Arg Leu Glu Ala Glu  Arg Arg Ala Arg Leu  Gln Asp Glu 
    1595                 1600                 1605             


Glu Arg  Arg Arg Gln Gln Gln  Leu Glu Glu Met Arg  Lys Arg Glu 
    1610                 1615                 1620             


Ala Glu  Asp Arg Ala Arg Gln  Glu Glu Glu Arg Arg  Arg Gln Glu 
    1625                 1630                 1635             


Glu Glu  Arg Xaa Lys Arg Asp  Ala Glu Glu Lys Arg  Arg Gln Glu 
    1640                 1645                 1650             


Glu Gly  Tyr Tyr Ser Arg Leu  Glu Ala Glu Arg Arg  Arg Gln His 
    1655                 1660                 1665             


Asp Glu  Ala Ala Arg Arg Leu  Leu Glu Pro Glu Ala  Pro Gly Leu 
    1670                 1675                 1680             


Cys Arg  Pro Pro Leu Pro Arg  Asp Tyr Glu Pro Pro  Ser Pro Ser 
    1685                 1690                 1695             


Pro Ala  Pro Gly Ala Pro Pro  Pro Pro Pro Gln Arg  Asn Ala Ser 
    1700                 1705                 1710             


Tyr Leu  Lys Xaa Gln Val Leu  Ser Pro Asp Ser Leu  Phe Xaa Ala 
    1715                 1720                 1725             


Lys Phe  Val Ala Tyr Asn Glu  Glu Glu Glu Glu Glu  Asp Cys Ser 
    1730                 1735                 1740             


Leu Ala  Gly Pro Asn Ser Tyr  Pro Gly Ser Xaa Gly  Ala Ala Val 
    1745                 1750                 1755             


Gly Ala  His Asp Ala Cys Arg  Asp Ala Lys Glu Lys  Arg Ser Lys 
    1760                 1765                 1770             


Ser Gln  Asp Ala Asp Ser Pro  Gly Ser Ser Gly Ala  Pro Glu Asn 
    1775                 1780                 1785             


Leu Xaa  Phe Lys Glu Arg Gln  Arg Leu Phe Ser Gln  Gly Gln Asp 
    1790                 1795                 1800             


Val Ser  Asn Lys Val Lys Ala  Ser Arg Lys Leu Xaa  Glu Leu Glu 
    1805                 1810                 1815             


Asn Glu  Leu Asn Xaa Lys 
    1820                 


<210> 1886
<211> 1831
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (983)..(983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1093)..(1093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1108)..(1108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1200)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1214)..(1214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1218)..(1218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1234)..(1234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1267)..(1267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1280)..(1280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1323)..(1323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1343)..(1343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1359)..(1359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1369)..(1369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1453)..(1453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1465)..(1465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1476)..(1476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1496)..(1496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1597)..(1597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1649)..(1649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1724)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1734)..(1734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1797)..(1797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1822)..(1822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1830)..(1830)
<223> Selenocysteine

<400> 1886
Met Ser Ala Gly Gly Arg Asp Glu Glu Arg Arg Lys Leu Ala Asp Ile 
1               5                   10                  15      


Ile His His Trp Asn Ala Asn Arg Leu Asp Leu Phe Glu Ile Ser Gln 
            20                  25                  30          


Pro Xaa Glu Asp Leu Glu Phe His Gly Val Met Arg Phe Tyr Phe Gln 
        35                  40                  45              


Asp Lys Ala Ala Gly Asn Phe Ala Xaa Lys Cys Ile Arg Val Ser Ser 
    50                  55                  60                  


Xaa Ala Xaa Xaa Gln Asp Val Ile Glu Xaa Leu Ala Glu Lys Phe Arg 
65                  70                  75                  80  


Pro Asp Met Arg Met Leu Ser Ser Pro Lys Tyr Ser Leu Tyr Glu Val 
                85                  90                  95      


His Val Ser Gly Glu Arg Arg Leu Asp Ile Asp Glu Lys Pro Leu Val 
            100                 105                 110         


Val Gln Leu Asn Trp Asn Lys Asp Asp Arg Glu Gly Arg Phe Val Leu 
        115                 120                 125             


Lys Asn Glu Asn Asp Ala Ile Pro Pro Lys Lys Ala Gln Ser Asn Gly 
    130                 135                 140                 


Pro Glu Lys Gln Glu Lys Glu Gly Val Ile Gln Asn Phe Lys Arg Xaa 
145                 150                 155                 160 


Leu Ser Lys Lys Glu Lys Lys Glu Lys Lys Lys Arg Glu Lys Glu Ala 
                165                 170                 175     


Leu Arg Gln Ala Ser Asp Lys Asp Asp Arg Pro Phe Gln Gly Glu Asp 
            180                 185                 190         


Val Glu Asn Ser Arg Leu Ala Ala Glu Val Tyr Lys Asp Met Pro Glu 
        195                 200                 205             


Xaa Ser Phe Xaa Arg Xaa Ile Ser Asn Pro Glu Val Val Met Lys Arg 
    210                 215                 220                 


Arg Arg Gln Gln Lys Leu Glu Lys Arg Met Gln Glu Phe Arg Ser Ser 
225                 230                 235                 240 


Asp Gly Arg Pro Asp Ser Gly Gly Xaa Leu Arg Ile Tyr Ala Asp Ser 
                245                 250                 255     


Leu Lys Pro Asn Ile Pro Tyr Lys Xaa Ile Leu Leu Ser Xaa Xaa Asp 
            260                 265                 270         


Pro Ala Asp Phe Ala Val Ala Glu Ala Leu Glu Lys Tyr Gly Leu Glu 
        275                 280                 285             


Lys Glu Asn Pro Lys Asp Tyr Cys Ile Ala Arg Val Met Leu Pro Pro 
    290                 295                 300                 


Gly Ala Gln His Ser Asp Glu Lys Gly Ala Lys Glu Ile Ile Leu Asp 
305                 310                 315                 320 


Asp Asp Glu Cys Pro Leu Gln Ile Phe Arg Glu Trp Pro Ser Asp Lys 
                325                 330                 335     


Gly Ile Leu Val Phe Gln Leu Lys Arg Arg Pro Pro Asp His Ile Pro 
            340                 345                 350         


Lys Lys Xaa Lys Lys His Leu Glu Gly Lys Xaa Pro Lys Gly Lys Glu 
        355                 360                 365             


Arg Ala Asp Gly Ser Gly Tyr Gly Ser Xaa Leu Pro Pro Glu Lys Leu 
    370                 375                 380                 


Pro Tyr Leu Val Glu Leu Ser Pro Gly Arg Arg Asn His Phe Ala Tyr 
385                 390                 395                 400 


Tyr Asn Tyr His Xaa Tyr Glu Asp Gly Ser Asp Ser Arg Asp Lys Pro 
                405                 410                 415     


Lys Leu Tyr Arg Leu Gln Leu Ser Val Xaa Glu Val Gly Xaa Glu Lys 
            420                 425                 430         


Leu Asp Asp Asn Ser Ile Gln Leu Phe Gly Pro Gly Ile Gln Pro His 
        435                 440                 445             


His Cys Asp Leu Xaa Asn Met Asp Gly Val Val Xaa Val Xaa Pro Arg 
    450                 455                 460                 


Ser Met Asp Ala Glu Xaa Tyr Val Glu Gly Gln Arg Ile Ser Glu Xaa 
465                 470                 475                 480 


Xaa Met Leu Gln Ser Gly Met Lys Val Gln Phe Gly Ala Ser His Val 
                485                 490                 495     


Phe Lys Phe Val Asp Pro Ser Gln Asp His Ala Leu Ala Lys Arg Ser 
            500                 505                 510         


Val Asp Gly Gly Leu Met Val Lys Gly Pro Arg His Lys Pro Gly Ile 
        515                 520                 525             


Val Gln Glu Xaa Xaa Phe Asp Leu Gly Gly Asp Ile His Ser Gly Xaa 
    530                 535                 540                 


Ala Leu Pro Xaa Ser Lys Ser Xaa Xaa Arg Leu Asp Ser Asp Arg Val 
545                 550                 555                 560 


Ser Ser Ala Ser Ser Xaa Ala Glu Arg Gly Met Val Lys Pro Met Ile 
                565                 570                 575     


Arg Val Glu Gln Gln Pro Asp Tyr Arg Arg Gln Glu Ser Arg Xaa Gln 
            580                 585                 590         


Asp Ala Ser Gly Pro Glu Leu Ile Leu Pro Ala Ser Ile Glu Phe Arg 
        595                 600                 605             


Glu Ser Ser Glu Asp Ser Phe Leu Ser Ala Ile Ile Asn Tyr Xaa Asn 
    610                 615                 620                 


Ser Ser Xaa Val His Phe Lys Leu Ser Pro Xaa Tyr Val Leu Tyr Met 
625                 630                 635                 640 


Ala Cys Arg Tyr Val Leu Ser Asn Gln Tyr Arg Pro Asp Ile Ser Pro 
                645                 650                 655     


Xaa Glu Arg Xaa His Lys Val Ile Ala Val Val Asn Lys Met Val Ser 
            660                 665                 670         


Met Met Glu Gly Val Ile Gln Glu Val Asp Gln Val Asp Gln Lys Gln 
        675                 680                 685             


Lys Asn Ile Ala Gly Ala Leu Ala Phe Trp Met Ala Asn Ala Ser Glu 
    690                 695                 700                 


Leu Leu Asn Phe Ile Lys Gln Asp Arg Asp Leu Ser Arg Ile Xaa Leu 
705                 710                 715                 720 


Asp Ala Gln Asp Val Leu Ala His Leu Val Gln Met Ala Phe Lys Tyr 
                725                 730                 735     


Leu Val His Cys Leu Gln Ser Glu Leu Asn Asn Tyr Met Pro Ala Phe 
            740                 745                 750         


Leu Asp Asp Pro Glu Glu Asn Ser Leu Gln Arg Pro Lys Ile Asp Asp 
        755                 760                 765             


Val Leu His Xaa Leu Xaa Gly Ala Met Ser Leu Leu Arg Arg Cys Arg 
    770                 775                 780                 


Val Asn Ala Ala Leu Xaa Ile Gln Leu Phe Ser Gln Leu Phe His Phe 
785                 790                 795                 800 


Ile Asn Met Trp Leu Phe Asn Arg Leu Val Xaa Asp Pro Asp Ser Gly 
                805                 810                 815     


Leu Cys Ser His Tyr Trp Gly Ala Ile Ile Arg Gln Gln Leu Gly His 
            820                 825                 830         


Ile Glu Ala Trp Ala Glu Lys Gln Gly Leu Glu Leu Ala Ala Asp Cys 
        835                 840                 845             


His Leu Ser Arg Ile Val Gln Ala Xaa Xaa Leu Leu Xaa Met Asp Lys 
    850                 855                 860                 


Tyr Ala Pro Asp Asp Ile Pro Asn Ile Asn Ser Xaa Cys Phe Lys Leu 
865                 870                 875                 880 


Asn Ser Leu Gln Leu Gln Ala Leu Leu Gln Asn Tyr His Cys Ala Pro 
                885                 890                 895     


Asp Glu Pro Phe Ile Pro Xaa Asp Leu Ile Glu Asn Val Val Xaa Val 
            900                 905                 910         


Ala Glu Asn Xaa Ala Asp Glu Leu Ala Arg Ser Asp Gly Arg Glu Val 
        915                 920                 925             


Gln Leu Glu Glu Asp Pro Asp Leu Gln Leu Pro Phe Leu Leu Pro Glu 
    930                 935                 940                 


Asp Gly Tyr Ser Cys Asp Val Val Arg Asn Ile Pro Asn Gly Leu Gln 
945                 950                 955                 960 


Glu Phe Leu Asp Pro Leu Cys Gln Arg Gly Phe Cys Arg Leu Ile Pro 
                965                 970                 975     


His Xaa Arg Ser Pro Gly Xaa Trp Xaa Ile Tyr Phe Glu Gly Ala Asp 
            980                 985                 990         


Tyr Glu Ser His Leu Leu Arg Glu  Asn Xaa Glu Leu Ala  Gln Pro Leu 
        995                 1000                 1005             


Arg Lys  Glu Pro Glu Ile Ile  Xaa Val Xaa Leu Lys  Lys Gln Asn 
    1010                 1015                 1020             


Gly Met  Gly Leu Ser Ile Val  Ala Ala Lys Gly Ala  Gly Gln Asp 
    1025                 1030                 1035             


Lys Leu  Gly Ile Tyr Val Lys  Ser Val Val Lys Gly  Gly Ala Ala 
    1040                 1045                 1050             


Asp Val  Asp Gly Arg Leu Ala  Ala Gly Asp Gln Leu  Leu Ser Val 
    1055                 1060                 1065             


Asp Gly  Arg Ser Leu Val Gly  Leu Ser Gln Glu Arg  Ala Ala Glu 
    1070                 1075                 1080             


Leu Met  Xaa Arg Xaa Ser Ser  Val Val Xaa Leu Glu  Val Ala Lys 
    1085                 1090                 1095             


Gln Gly  Ala Ile Tyr His Gly  Leu Ala Xaa Leu Leu  Asn Gln Pro 
    1100                 1105                 1110             


Ser Pro  Met Met Gln Arg Ile  Ser Asp Arg Arg Gly  Ser Gly Lys 
    1115                 1120                 1125             


Pro Arg  Pro Lys Ser Glu Gly  Phe Glu Leu Tyr Asn  Asn Ser Xaa 
    1130                 1135                 1140             


Gln Asn  Gly Ser Pro Glu Ser  Pro Gln Leu Pro Trp  Ala Glu Tyr 
    1145                 1150                 1155             


Ser Glu  Pro Lys Lys Leu Pro  Gly Asp Asp Arg Leu  Met Lys Asn 
    1160                 1165                 1170             


Arg Ala  Asp His Arg Ser Ser  Pro Asn Val Ala Asn  Gln Pro Pro 
    1175                 1180                 1185             


Ser Pro  Gly Gly Lys Ser Ala  Tyr Ala Ser Gly Xaa  Xaa Ala Lys 
    1190                 1195                 1200             


Ile Xaa  Ser Val Ser Xaa Gly  Asn Leu Cys Xaa Glu  Glu Gln Xaa 
    1205                 1210                 1215             


Pro Pro  Pro Arg Pro Glu Ala  Tyr Pro Ile Pro Xaa  Gln Xaa Tyr 
    1220                 1225                 1230             


Xaa Arg  Glu Tyr Phe Xaa Phe  Pro Ala Ser Lys Ser  Gln Asp Arg 
    1235                 1240                 1245             


Met Ala  Pro Pro Gln Asn Gln  Trp Pro Asn Tyr Glu  Glu Lys Pro 
    1250                 1255                 1260             


His Met  His Xaa Asp Ser Asn  His Ser Ser Ile Ala  Ile Gln Arg 
    1265                 1270                 1275             


Val Xaa  Arg Ser Gln Glu Glu  Leu Arg Glu Asp Lys  Ala Tyr Gln 
    1280                 1285                 1290             


Leu Glu  Arg His Arg Ile Glu  Ala Ala Met Asp Arg  Lys Ser Asp 
    1295                 1300                 1305             


Ser Asp  Met Trp Ile Asn Gln  Ser Ser Ser Leu Asp  Ser Ser Xaa 
    1310                 1315                 1320             


Ser Ser  Gln Glu His Leu Asn  His Ser Ser Lys Ser  Val Xaa Pro 
    1325                 1330                 1335             


Ala Ser  Xaa Leu Xaa Lys Ser  Gly Pro Gly Arg Trp  Lys Xaa Pro 
    1340                 1345                 1350             


Ala Ala  Ile Pro Ala Xaa Pro  Val Ala Val Ser Gln  Pro Ile Arg 
    1355                 1360                 1365             


Xaa Asp  Leu Pro Pro Pro Pro  Pro Pro Pro Pro Val  His Tyr Ala 
    1370                 1375                 1380             


Gly Asp  Phe Asp Gly Met Ser  Met Asp Leu Pro Leu  Pro Pro Pro 
    1385                 1390                 1395             


Pro Ser  Ala Asn Gln Ile Gly  Leu Pro Ser Ala Gln  Val Ala Ala 
    1400                 1405                 1410             


Ala Glu  Arg Arg Lys Arg Glu  Glu His Gln Arg Trp  Tyr Glu Lys 
    1415                 1420                 1425             


Glu Lys  Ala Arg Leu Glu Glu  Glu Arg Glu Arg Lys  Arg Arg Glu 
    1430                 1435                 1440             


Gln Glu  Arg Lys Leu Gly Gln  Met Arg Xaa Gln Ser  Leu Asn Pro 
    1445                 1450                 1455             


Ala Pro  Phe Ser Pro Leu Xaa  Ala Gln Gln Met Lys  Pro Glu Lys 
    1460                 1465                 1470             


Pro Ser  Xaa Leu Gln Arg Pro  Gln Glu Xaa Val Ile  Arg Glu Leu 
    1475                 1480                 1485             


Gln Pro  Gln Gln Gln Pro Arg  Xaa Ile Glu Arg Arg  Asp Leu Gln 
    1490                 1495                 1500             


Tyr Ile  Xaa Val Ser Lys Glu  Glu Leu Ser Ser Gly  Asp Ser Leu 
    1505                 1510                 1515             


Ser Pro  Asp Pro Trp Lys Arg  Asp Ala Lys Glu Lys  Leu Glu Lys 
    1520                 1525                 1530             


Gln Gln  Gln Met His Ile Val  Asp Met Leu Ser Lys  Glu Ile Gln 
    1535                 1540                 1545             


Glu Leu  Gln Ser Lys Pro Asp  Arg Ser Ala Glu Glu  Ser Asp Arg 
    1550                 1555                 1560             


Leu Arg  Lys Leu Met Leu Glu  Trp Gln Phe Gln Lys  Arg Leu Gln 
    1565                 1570                 1575             


Glu Ser  Lys Gln Lys Asp Glu  Asp Asp Glu Glu Glu  Glu Asp Asp 
    1580                 1585                 1590             


Asp Val  Asp Xaa Met Leu Ile  Met Gln Arg Leu Glu  Ala Glu Arg 
    1595                 1600                 1605             


Arg Ala  Arg Leu Gln Asp Glu  Glu Arg Arg Arg Gln  Gln Gln Leu 
    1610                 1615                 1620             


Glu Glu  Met Arg Lys Arg Glu  Ala Glu Asp Arg Ala  Arg Gln Glu 
    1625                 1630                 1635             


Glu Glu  Arg Arg Arg Gln Glu  Glu Glu Arg Xaa Lys  Arg Asp Ala 
    1640                 1645                 1650             


Glu Glu  Lys Arg Arg Gln Glu  Glu Gly Tyr Tyr Ser  Arg Leu Glu 
    1655                 1660                 1665             


Ala Glu  Arg Arg Arg Gln His  Asp Glu Ala Ala Arg  Arg Leu Leu 
    1670                 1675                 1680             


Glu Pro  Glu Ala Pro Gly Leu  Cys Arg Pro Pro Leu  Pro Arg Asp 
    1685                 1690                 1695             


Tyr Glu  Pro Pro Ser Pro Ser  Pro Ala Pro Gly Ala  Pro Pro Pro 
    1700                 1705                 1710             


Pro Pro  Gln Arg Asn Ala Ser  Tyr Leu Lys Xaa Gln  Val Leu Ser 
    1715                 1720                 1725             


Pro Asp  Ser Leu Phe Xaa Ala  Lys Phe Val Ala Tyr  Asn Glu Glu 
    1730                 1735                 1740             


Glu Glu  Glu Glu Asp Cys Ser  Leu Ala Gly Pro Asn  Ser Tyr Pro 
    1745                 1750                 1755             


Gly Ser  Xaa Gly Ala Ala Val  Gly Ala His Asp Ala  Cys Arg Asp 
    1760                 1765                 1770             


Ala Lys  Glu Lys Arg Ser Lys  Ser Gln Asp Ala Asp  Ser Pro Gly 
    1775                 1780                 1785             


Ser Ser  Gly Ala Pro Glu Asn  Leu Xaa Phe Lys Glu  Arg Gln Arg 
    1790                 1795                 1800             


Leu Phe  Ser Gln Gly Gln Asp  Val Ser Asn Lys Val  Lys Ala Ser 
    1805                 1810                 1815             


Arg Lys  Leu Xaa Glu Leu Glu  Asn Glu Leu Asn Xaa  Lys 
    1820                 1825                 1830     


<210> 1887
<211> 124
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<400> 1887
Xaa Asp Gly Val Phe Leu Ser Asn Ser Phe Gln Pro Pro Ser Ala Lys 
1               5                   10                  15      


Ala Asn Ser Xaa Ala His Lys Lys Gly Gln Pro Leu Pro Pro Pro Lys 
            20                  25                  30          


Lys Ser Ser Ser Tyr His Pro Ser His Cys Lys Gly Arg Gly Pro Asn 
        35                  40                  45              


Ser Tyr Pro Gly Ser Xaa Gly Ala Ala Val Gly Ala His Asp Ala Cys 
    50                  55                  60                  


Arg Asp Ala Lys Glu Lys Arg Ser Lys Ser Gln Asp Ala Asp Ser Pro 
65                  70                  75                  80  


Gly Ser Ser Gly Ala Pro Glu Asn Leu Xaa Phe Lys Glu Arg Gln Arg 
                85                  90                  95      


Leu Phe Ser Gln Gly Gln Asp Val Ser Asn Lys Val Lys Ala Ser Arg 
            100                 105                 110         


Lys Leu Xaa Glu Leu Glu Asn Glu Leu Asn Xaa Lys 
        115                 120                 


<210> 1888
<211> 389
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<400> 1888
Xaa Glu Lys Glu Asn Pro Lys Asp Tyr Cys Ile Ala Arg Val Met Leu 
1               5                   10                  15      


Pro Pro Gly Ala Gln His Ser Asp Glu Lys Gly Ala Lys Glu Ile Ile 
            20                  25                  30          


Leu Asp Asp Asp Glu Cys Pro Leu Gln Ile Phe Arg Glu Trp Pro Ser 
        35                  40                  45              


Asp Lys Gly Ile Leu Val Phe Gln Leu Lys Arg Arg Pro Pro Asp His 
    50                  55                  60                  


Ile Pro Lys Lys Xaa Lys Lys His Leu Glu Gly Lys Xaa Pro Lys Gly 
65                  70                  75                  80  


Lys Glu Arg Ala Asp Gly Ser Gly Tyr Gly Ser Xaa Leu Pro Pro Glu 
                85                  90                  95      


Lys Leu Pro Tyr Leu Val Glu Leu Ser Pro Asp Gly Ser Asp Ser Arg 
            100                 105                 110         


Asp Lys Pro Lys Leu Tyr Arg Leu Gln Leu Ser Val Xaa Glu Val Gly 
        115                 120                 125             


Xaa Glu Lys Leu Asp Asp Asn Ser Ile Gln Leu Phe Gly Pro Gly Ile 
    130                 135                 140                 


Gln Pro His His Cys Asp Leu Xaa Asn Met Asp Gly Val Val Xaa Val 
145                 150                 155                 160 


Xaa Pro Arg Ser Met Asp Ala Glu Xaa Tyr Val Glu Gly Gln Arg Ile 
                165                 170                 175     


Ser Glu Xaa Xaa Met Leu Gln Ser Gly Met Lys Val Gln Phe Gly Ala 
            180                 185                 190         


Ser His Val Phe Lys Phe Val Asp Pro Ser Gln Asp His Ala Leu Ala 
        195                 200                 205             


Lys Arg Ser Val Asp Gly Gly Leu Met Val Lys Gly Pro Arg His Lys 
    210                 215                 220                 


Pro Gly Ile Val Gln Glu Xaa Xaa Phe Asp Leu Gly Gly Asp Ile His 
225                 230                 235                 240 


Ser Gly Xaa Ala Leu Pro Xaa Ser Lys Ser Xaa Xaa Arg Leu Asp Ser 
                245                 250                 255     


Asp Arg Val Ser Ser Ala Ser Ser Xaa Ala Glu Arg Gly Met Val Lys 
            260                 265                 270         


Pro Met Ile Arg Val Glu Gln Gln Pro Asp Tyr Arg Arg Gln Glu Ser 
        275                 280                 285             


Arg Xaa Gln Asp Ala Ser Gly Pro Glu Leu Ile Leu Pro Ala Ser Ile 
    290                 295                 300                 


Glu Phe Arg Glu Ser Ser Glu Asp Ser Phe Leu Ser Ala Ile Ile Asn 
305                 310                 315                 320 


Tyr Xaa Asn Ser Ser Xaa Val His Phe Lys Leu Ser Pro Xaa Tyr Val 
                325                 330                 335     


Leu Tyr Met Ala Cys Arg Tyr Val Leu Ser Asn Gln Tyr Arg Pro Asp 
            340                 345                 350         


Ile Ser Pro Xaa Glu Arg Xaa His Lys Val Ile Ala Val Val Asn Lys 
        355                 360                 365             


Met Val Ser Met Met Glu Gly Val Ile Gln Val Arg Ser Ser Arg Pro 
    370                 375                 380                 


Ala Met Leu Leu Gln 
385                 


<210> 1889
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<400> 1889
Xaa Lys Gln Gln Gln Met His Ile Val Asp Met Leu Ser Lys Glu Ile 
1               5                   10                  15      


Gln Glu Leu Gln Ser Lys Pro Asp Arg Ser Ala Glu Glu Ser Asp Arg 
            20                  25                  30          


Leu Arg Lys Leu Met Leu Glu Trp Gln Phe Gln Lys Arg Leu Gln Glu 
        35                  40                  45              


Ser Lys Gln Lys Asp Glu Asp Asp Glu Glu Glu Glu Asp Asp Asp Val 
    50                  55                  60                  


Asp Xaa Met Leu Ile Met Gln Arg Leu Glu Ala Glu Arg Arg Ala Arg 
65                  70                  75                  80  


Leu Gln Asp Glu Glu Arg Arg Arg Gln Gln Gln Leu Glu Glu Met Arg 
                85                  90                  95      


Lys Arg Glu Ala Glu Asp Arg Ala Arg Gln Glu Glu Glu Arg Arg Arg 
            100                 105                 110         


Gln Glu Glu Glu Arg Xaa Lys Arg Asp Ala Glu Glu Lys Val Met Val 
        115                 120                 125             


Leu 
    


<210> 1890
<211> 313
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<400> 1890
Xaa Leu Ser Pro Asp Pro Trp Lys Arg Asp Ala Lys Glu Lys Leu Glu 
1               5                   10                  15      


Lys Gln Gln Gln Met His Ile Val Asp Met Leu Ser Lys Glu Ile Gln 
            20                  25                  30          


Glu Leu Gln Ser Lys Pro Asp Arg Ser Ala Glu Glu Ser Asp Arg Leu 
        35                  40                  45              


Arg Lys Leu Met Leu Glu Trp Gln Phe Gln Lys Arg Leu Gln Glu Ser 
    50                  55                  60                  


Lys Gln Lys Asp Glu Asp Asp Glu Glu Glu Glu Asp Asp Asp Val Asp 
65                  70                  75                  80  


Xaa Met Leu Ile Met Gln Arg Leu Glu Ala Glu Arg Arg Ala Arg Asp 
                85                  90                  95      


Glu Glu Arg Arg Arg Gln Gln Gln Leu Glu Glu Met Arg Lys Arg Glu 
            100                 105                 110         


Ala Glu Asp Arg Ala Arg Gln Glu Glu Glu Arg Arg Arg Gln Glu Glu 
        115                 120                 125             


Glu Arg Xaa Lys Arg Asp Ala Glu Glu Lys Arg Arg Gln Glu Glu Gly 
    130                 135                 140                 


Tyr Tyr Ser Arg Leu Glu Ala Glu Arg Arg Arg Gln His Asp Glu Ala 
145                 150                 155                 160 


Ala Arg Arg Leu Leu Glu Pro Glu Ala Pro Gly Leu Cys Arg Pro Pro 
                165                 170                 175     


Leu Pro Arg Asp Tyr Glu Pro Pro Ser Pro Ser Pro Ala Pro Gly Ala 
            180                 185                 190         


Pro Pro Pro Pro Pro Gln Arg Asn Ala Ser Tyr Leu Lys Xaa Gln Val 
        195                 200                 205             


Leu Ser Pro Asp Ser Leu Phe Xaa Ala Lys Phe Val Ala Tyr Asn Glu 
    210                 215                 220                 


Glu Glu Glu Glu Glu Asp Cys Ser Leu Ala Gly Pro Asn Ser Tyr Pro 
225                 230                 235                 240 


Gly Ser Xaa Gly Ala Ala Val Gly Ala His Asp Ala Cys Arg Asp Ala 
                245                 250                 255     


Lys Glu Lys Arg Ser Lys Ser Gln Asp Ala Asp Ser Pro Gly Ser Ser 
            260                 265                 270         


Gly Ala Pro Glu Asn Leu Xaa Phe Lys Glu Arg Gln Arg Leu Phe Ser 
        275                 280                 285             


Gln Gly Gln Asp Val Ser Asn Lys Val Lys Ala Ser Arg Lys Leu Xaa 
    290                 295                 300                 


Glu Leu Glu Asn Glu Leu Asn Xaa Lys 
305                 310             


<210> 1891
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<400> 1891
Xaa Arg Asn Ala Ser Tyr Leu Lys Xaa Gln Val Leu Ser Pro Asp Ser 
1               5                   10                  15      


Leu Phe Xaa Ala Lys Phe Val Ala Tyr Asn Glu Glu Glu Glu Glu Glu 
            20                  25                  30          


Asp Cys Ser Leu Ala Gly Gln Asp Lys Tyr Ser Ser Xaa Arg Lys Ser 
        35                  40                  45              


His Gly Asp Leu Leu Pro Ala Pro Leu Lys Pro Arg Pro Pro Pro Cys 
    50                  55                  60                  


Gln Pro Arg Pro Ala Ser Asp Gly Val Phe Leu Ser Asn Ser Phe Gln 
65                  70                  75                  80  


Pro Pro Ser Ala Lys Ala Asn Ser Xaa Ala His Lys Lys Gly Gln Pro 
                85                  90                  95      


Leu Pro Pro Pro Lys Lys Ser Ser Ser Tyr His Pro Ser His Cys Lys 
            100                 105                 110         


Gly Pro Asn Ser Tyr Pro Gly Ser Xaa Gly Ala Ala Val Gly Ala His 
        115                 120                 125             


Asp Ala Cys Arg Asp Ala Lys Glu Lys Arg Ser Lys Ser Gln Asp Ala 
    130                 135                 140                 


Asp Ser Pro Gly Ser Ser Gly Ala Pro Glu Asn Leu Xaa Phe Lys Glu 
145                 150                 155                 160 


Arg Gln Arg Leu Phe Ser Gln Gly Gln Asp Val Ser Asn Lys Val Lys 
                165                 170                 175     


Ala Ser Arg Lys Leu Xaa Glu Leu Glu Asn Glu Leu Asn Xaa Lys 
            180                 185                 190     


<210> 1892
<211> 1205
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1131)..(1131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1191)..(1191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<400> 1892
Met Ala Ala Gln Ser Ser Leu Tyr Asn Asp Asp Arg Asn Leu Leu Arg 
1               5                   10                  15      


Ile Arg Glu Lys Glu Arg Arg Asn Gln Glu Ala His Gln Glu Lys Glu 
            20                  25                  30          


Ala Phe Pro Glu Lys Ile Pro Leu Phe Gly Glu Pro Tyr Lys Xaa Ala 
        35                  40                  45              


Lys Gly Asp Glu Leu Ser Ser Arg Ile Gln Asn Met Leu Gly Asn Tyr 
    50                  55                  60                  


Glu Glu Val Lys Glu Phe Leu Ser Xaa Lys Ser His Xaa His Arg Leu 
65                  70                  75                  80  


Asp Ala Ser Glu Asn Arg Leu Gly Lys Pro Lys Tyr Pro Leu Ile Pro 
                85                  90                  95      


Asp Lys Gly Ser Ser Ile Pro Ser Ser Ser Phe His Xaa Ser Val His 
            100                 105                 110         


His Gln Ser Ile His Xaa Pro Ala Ser Gly Pro Leu Ser Val Gly Asn 
        115                 120                 125             


Ile Ser His Asn Pro Lys Met Ala Gln Pro Arg Xaa Glu Pro Met Pro 
    130                 135                 140                 


Ser Leu His Ala Lys Ser Cys Gly Pro Pro Asp Ser Gln His Leu Xaa 
145                 150                 155                 160 


Gln Asp Arg Leu Gly Gln Glu Gly Phe Gly Ser Ser His His Lys Lys 
                165                 170                 175     


Gly Asp Arg Arg Ala Asp Gly Asp His Cys Ala Ser Val Xaa Asp Ser 
            180                 185                 190         


Ala Pro Glu Arg Glu Leu Ser Pro Leu Ile Ser Leu Pro Ser Pro Val 
        195                 200                 205             


Pro Pro Leu Ser Pro Ile His Ser Asn Gln Gln Xaa Leu Pro Arg Xaa 
    210                 215                 220                 


Gln Gly Ser Ser Lys Val His Gly Ser Ser Asn Asn Ser Lys Gly Tyr 
225                 230                 235                 240 


Cys Pro Ala Lys Ser Pro Lys Asp Leu Ala Val Lys Val His Asp Lys 
                245                 250                 255     


Glu Xaa Pro Gln Asp Ser Leu Val Ala Pro Ala Gln Pro Pro Ser Gln 
            260                 265                 270         


Xaa Phe Pro Pro Pro Ser Leu Pro Ser Lys Ser Val Ala Met Gln Gln 
        275                 280                 285             


Lys Pro Xaa Ala Tyr Val Arg Pro Met Asp Gly Gln Asp Gln Ala Pro 
    290                 295                 300                 


Ser Glu Ser Pro Glu Leu Lys Pro Leu Pro Glu Asp Tyr Arg Gln Gln 
305                 310                 315                 320 


Xaa Phe Glu Lys Xaa Asp Leu Lys Val Pro Ala Lys Ala Lys Leu Xaa 
                325                 330                 335     


Lys Leu Lys Met Pro Ser Gln Ser Val Glu Gln Xaa Tyr Ser Asn Glu 
            340                 345                 350         


Val His Cys Val Glu Glu Ile Leu Lys Glu Met Xaa His Ser Trp Pro 
        355                 360                 365             


Pro Pro Leu Xaa Ala Ile His Xaa Pro Ser Xaa Ala Glu Pro Ser Lys 
    370                 375                 380                 


Phe Pro Phe Pro Xaa Lys Asp Ser Gln His Val Ser Ser Val Xaa Gln 
385                 390                 395                 400 


Asn Gln Lys Gln Tyr Asp Xaa Ser Ser Lys Xaa His Ser Asn Ser Gln 
                405                 410                 415     


Gln Gly Xaa Ser Ser Met Leu Glu Asp Asp Leu Gln Leu Ser Asp Ser 
            420                 425                 430         


Glu Asp Ser Asp Ser Glu Gln Xaa Pro Glu Lys Pro Pro Ser Ser Ser 
        435                 440                 445             


Ala Pro Pro Ser Ala Pro Gln Ser Leu Pro Glu Pro Val Ala Ser Ala 
    450                 455                 460                 


His Ser Ser Ser Ala Glu Ser Glu Ser Xaa Ser Asp Ser Asp Ser Ser 
465                 470                 475                 480 


Ser Asp Ser Glu Ser Glu Ser Ser Ser Ser Asp Ser Glu Glu Asn Glu 
                485                 490                 495     


Pro Leu Glu Xaa Pro Ala Pro Glu Pro Glu Pro Pro Xaa Xaa Asn Lys 
            500                 505                 510         


Trp Gln Leu Asp Asn Trp Leu Xaa Lys Val Ser Gln Pro Ala Ala Pro 
        515                 520                 525             


Pro Glu Gly Pro Arg Ser Xaa Glu Pro Pro Arg Arg His Pro Glu Ser 
    530                 535                 540                 


Lys Gly Ser Ser Asp Ser Ala Xaa Ser Gln Glu His Ser Glu Ser Lys 
545                 550                 555                 560 


Asp Pro Pro Pro Lys Ser Ser Ser Lys Ala Pro Arg Ala Pro Pro Glu 
                565                 570                 575     


Ala Pro His Pro Gly Lys Arg Ser Cys Gln Lys Ser Pro Ala Gln Gln 
            580                 585                 590         


Glu Pro Pro Gln Arg Gln Xaa Val Gly Xaa Lys Gln Pro Lys Lys Pro 
        595                 600                 605             


Val Lys Ala Ser Ala Arg Ala Gly Ser Arg Xaa Ser Leu Gln Gly Glu 
    610                 615                 620                 


Arg Glu Pro Gly Leu Leu Pro Tyr Gly Ser Arg Asp Gln Xaa Ser Lys 
625                 630                 635                 640 


Asp Lys Pro Lys Val Lys Xaa Lys Gly Arg Pro Arg Ala Ala Ala Ser 
                645                 650                 655     


Asn Glu Pro Lys Pro Ala Val Pro Pro Ser Ser Glu Lys Lys Lys His 
            660                 665                 670         


Lys Ser Ser Leu Pro Ala Pro Ser Lys Ala Leu Ser Gly Pro Glu Pro 
        675                 680                 685             


Ala Lys Asp Asn Val Glu Asp Arg Xaa Pro Glu His Phe Ala Leu Val 
    690                 695                 700                 


Pro Leu Xaa Glu Ser Gln Gly Pro Pro His Ser Gly Ser Gly Ser Arg 
705                 710                 715                 720 


Xaa Ser Gly Cys Arg Gln Ala Val Val Val Gln Glu Asp Ser Arg Lys 
                725                 730                 735     


Asp Arg Leu Pro Leu Pro Leu Arg Asp Xaa Lys Leu Leu Ser Pro Leu 
            740                 745                 750         


Arg Asp Xaa Pro Pro Pro Gln Ser Leu Met Val Lys Ile Xaa Leu Asp 
        755                 760                 765             


Leu Leu Ser Arg Ile Pro Gln Pro Pro Gly Lys Gly Ser Arg Gln Arg 
    770                 775                 780                 


Lys Ala Glu Asp Lys Gln Pro Pro Ala Gly Lys Lys His Ser Ser Glu 
785                 790                 795                 800 


Lys Arg Ser Ser Asp Ser Ser Ser Lys Leu Ala Lys Lys Arg Lys Gly 
                805                 810                 815     


Glu Ala Glu Arg Asp Cys Asp Asn Lys Lys Ile Arg Leu Glu Lys Glu 
            820                 825                 830         


Ile Lys Ser Gln Ser Ser Ser Ser Ser Ser Ser His Lys Glu Ser Ser 
        835                 840                 845             


Lys Xaa Lys Pro Ser Arg Pro Ser Ser Gln Ser Ser Lys Lys Glu Met 
    850                 855                 860                 


Leu Pro Pro Pro Pro Val Ser Ser Ser Ser Gln Lys Pro Ala Lys Pro 
865                 870                 875                 880 


Ala Leu Lys Arg Ser Arg Arg Glu Ala Asp Xaa Cys Gly Gln Asp Pro 
                885                 890                 895     


Pro Lys Val Pro Ala Val Pro Arg Ala Xaa Xaa Asp Ser Ser Ile Pro 
            900                 905                 910         


Lys Gln Arg Arg Val Glu Gly Lys Gly Ser Arg Ser Ser Ser Glu His 
        915                 920                 925             


Lys Gly Ser Ser Gly Asp Xaa Ala Asn Pro Phe Pro Val Pro Ser Leu 
    930                 935                 940                 


Pro Asn Gly Asn Ser Lys Pro Gly Lys Pro Gln Val Lys Phe Asp Lys 
945                 950                 955                 960 


Gln Gln Ala Asp Leu His Met Arg Glu Ala Lys Lys Met Lys Gln Lys 
                965                 970                 975     


Ala Glu Leu Met Xaa Asp Arg Val Gly Lys Ala Phe Lys Tyr Leu Glu 
            980                 985                 990         


Ala Val Leu Ser Phe Ile Glu Cys  Gly Ile Ala Xaa Glu  Ser Glu Ser 
        995                 1000                 1005             


Gln Ser  Ser Lys Ser Ala Tyr  Ser Val Tyr Ser Glu  Xaa Val Asp 
    1010                 1015                 1020             


Leu Ile  Lys Phe Ile Met Ser  Leu Lys Ser Phe Ser  Asp Ala Xaa 
    1025                 1030                 1035             


Ala Pro  Xaa Gln Glu Lys Ile  Phe Ala Val Leu Cys  Met Arg Cys 
    1040                 1045                 1050             


Gln Ser  Ile Leu Asn Met Ala  Met Phe Arg Cys Lys  Lys Asp Ile 
    1055                 1060                 1065             


Ala Ile  Lys Tyr Ser Arg Xaa  Leu Asn Lys His Phe  Glu Ser Ser 
    1070                 1075                 1080             


Ser Lys  Val Ala Gln Ala Pro  Ser Pro Cys Ile Ala  Arg Ser Xaa 
    1085                 1090                 1095             


Gly Xaa  Pro Ser Pro Leu Ser  Pro Met Pro Ser Pro  Ala Ser Ser 
    1100                 1105                 1110             


Val Gly  Ser Gln Ser Ser Ala  Gly Ser Val Gly Ser  Ser Gly Val 
    1115                 1120                 1125             


Ala Ala  Xaa Ile Ser Xaa Pro  Val Xaa Ile Gln Asn  Met Xaa Ser 
    1130                 1135                 1140             


Ser Tyr  Val Xaa Ile Xaa Ser  His Val Leu Xaa Ala  Phe Asp Leu 
    1145                 1150                 1155             


Trp Glu  Gln Ala Glu Ala Leu  Xaa Arg Lys Asn Lys  Glu Phe Phe 
    1160                 1165                 1170             


Ala Arg  Leu Ser Gln Met Cys  Ala Pro Trp Pro Ser  Xaa Ala Val 
    1175                 1180                 1185             


Trp Trp  Xaa Trp Cys Xaa Ile  His Asp Arg Val Phe  Ser Ser Tyr 
    1190                 1195                 1200             


Lys Asn  
    1205 


<210> 1893
<211> 1210
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1131)..(1131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<400> 1893
Met Ala Ala Gln Ser Ser Leu Tyr Asn Asp Asp Arg Asn Leu Leu Arg 
1               5                   10                  15      


Ile Arg Glu Lys Glu Arg Arg Asn Gln Glu Ala His Gln Glu Lys Glu 
            20                  25                  30          


Ala Phe Pro Glu Lys Ile Pro Leu Phe Gly Glu Pro Tyr Lys Xaa Ala 
        35                  40                  45              


Lys Gly Asp Glu Leu Ser Ser Arg Ile Gln Asn Met Leu Gly Asn Tyr 
    50                  55                  60                  


Glu Glu Val Lys Glu Phe Leu Ser Xaa Lys Ser His Xaa His Arg Leu 
65                  70                  75                  80  


Asp Ala Ser Glu Asn Arg Leu Gly Lys Pro Lys Tyr Pro Leu Ile Pro 
                85                  90                  95      


Asp Lys Gly Ser Ser Ile Pro Ser Ser Ser Phe His Xaa Ser Val His 
            100                 105                 110         


His Gln Ser Ile His Xaa Pro Ala Ser Gly Pro Leu Ser Val Gly Asn 
        115                 120                 125             


Ile Ser His Asn Pro Lys Met Ala Gln Pro Arg Xaa Glu Pro Met Pro 
    130                 135                 140                 


Ser Leu His Ala Lys Ser Cys Gly Pro Pro Asp Ser Gln His Leu Xaa 
145                 150                 155                 160 


Gln Asp Arg Leu Gly Gln Glu Gly Phe Gly Ser Ser His His Lys Lys 
                165                 170                 175     


Gly Asp Arg Arg Ala Asp Gly Asp His Cys Ala Ser Val Xaa Asp Ser 
            180                 185                 190         


Ala Pro Glu Arg Glu Leu Ser Pro Leu Ile Ser Leu Pro Ser Pro Val 
        195                 200                 205             


Pro Pro Leu Ser Pro Ile His Ser Asn Gln Gln Xaa Leu Pro Arg Xaa 
    210                 215                 220                 


Gln Gly Ser Ser Lys Val His Gly Ser Ser Asn Asn Ser Lys Gly Tyr 
225                 230                 235                 240 


Cys Pro Ala Lys Ser Pro Lys Asp Leu Ala Val Lys Val His Asp Lys 
                245                 250                 255     


Glu Xaa Pro Gln Asp Ser Leu Val Ala Pro Ala Gln Pro Pro Ser Gln 
            260                 265                 270         


Xaa Phe Pro Pro Pro Ser Leu Pro Ser Lys Ser Val Ala Met Gln Gln 
        275                 280                 285             


Lys Pro Xaa Ala Tyr Val Arg Pro Met Asp Gly Gln Asp Gln Ala Pro 
    290                 295                 300                 


Ser Glu Ser Pro Glu Leu Lys Pro Leu Pro Glu Asp Tyr Arg Gln Gln 
305                 310                 315                 320 


Xaa Phe Glu Lys Xaa Asp Leu Lys Val Pro Ala Lys Ala Lys Leu Xaa 
                325                 330                 335     


Lys Leu Lys Met Pro Ser Gln Ser Val Glu Gln Xaa Tyr Ser Asn Glu 
            340                 345                 350         


Val His Cys Val Glu Glu Ile Leu Lys Glu Met Xaa His Ser Trp Pro 
        355                 360                 365             


Pro Pro Leu Xaa Ala Ile His Xaa Pro Ser Xaa Ala Glu Pro Ser Lys 
    370                 375                 380                 


Phe Pro Phe Pro Xaa Lys Asp Ser Gln His Val Ser Ser Val Xaa Gln 
385                 390                 395                 400 


Asn Gln Lys Gln Tyr Asp Xaa Ser Ser Lys Xaa His Ser Asn Ser Gln 
                405                 410                 415     


Gln Gly Xaa Ser Ser Met Leu Glu Asp Asp Leu Gln Leu Ser Asp Ser 
            420                 425                 430         


Glu Asp Ser Asp Ser Glu Gln Xaa Pro Glu Lys Pro Pro Ser Ser Ser 
        435                 440                 445             


Ala Pro Pro Ser Ala Pro Gln Ser Leu Pro Glu Pro Val Ala Ser Ala 
    450                 455                 460                 


His Ser Ser Ser Ala Glu Ser Glu Ser Xaa Ser Asp Ser Asp Ser Ser 
465                 470                 475                 480 


Ser Asp Ser Glu Ser Glu Ser Ser Ser Ser Asp Ser Glu Glu Asn Glu 
                485                 490                 495     


Pro Leu Glu Xaa Pro Ala Pro Glu Pro Glu Pro Pro Xaa Xaa Asn Lys 
            500                 505                 510         


Trp Gln Leu Asp Asn Trp Leu Xaa Lys Val Ser Gln Pro Ala Ala Pro 
        515                 520                 525             


Pro Glu Gly Pro Arg Ser Xaa Glu Pro Pro Arg Arg His Pro Glu Ser 
    530                 535                 540                 


Lys Gly Ser Ser Asp Ser Ala Xaa Ser Gln Glu His Ser Glu Ser Lys 
545                 550                 555                 560 


Asp Pro Pro Pro Lys Ser Ser Ser Lys Ala Pro Arg Ala Pro Pro Glu 
                565                 570                 575     


Ala Pro His Pro Gly Lys Arg Ser Cys Gln Lys Ser Pro Ala Gln Gln 
            580                 585                 590         


Glu Pro Pro Gln Arg Gln Xaa Val Gly Xaa Lys Gln Pro Lys Lys Pro 
        595                 600                 605             


Val Lys Ala Ser Ala Arg Ala Gly Ser Arg Xaa Ser Leu Gln Gly Glu 
    610                 615                 620                 


Arg Glu Pro Gly Leu Leu Pro Tyr Gly Ser Arg Asp Gln Xaa Ser Lys 
625                 630                 635                 640 


Asp Lys Pro Lys Val Lys Xaa Lys Gly Arg Pro Arg Ala Ala Ala Ser 
                645                 650                 655     


Asn Glu Pro Lys Pro Ala Val Pro Pro Ser Ser Glu Lys Lys Lys His 
            660                 665                 670         


Lys Ser Ser Leu Pro Ala Pro Ser Lys Ala Leu Ser Gly Pro Glu Pro 
        675                 680                 685             


Ala Lys Asp Asn Val Glu Asp Arg Xaa Pro Glu His Phe Ala Leu Val 
    690                 695                 700                 


Pro Leu Xaa Glu Ser Gln Gly Pro Pro His Ser Gly Ser Gly Ser Arg 
705                 710                 715                 720 


Xaa Ser Gly Cys Arg Gln Ala Val Val Val Gln Glu Asp Ser Arg Lys 
                725                 730                 735     


Asp Arg Leu Pro Leu Pro Leu Arg Asp Xaa Lys Leu Leu Ser Pro Leu 
            740                 745                 750         


Arg Asp Xaa Pro Pro Pro Gln Ser Leu Met Val Lys Ile Xaa Leu Asp 
        755                 760                 765             


Leu Leu Ser Arg Ile Pro Gln Pro Pro Gly Lys Gly Ser Arg Gln Arg 
    770                 775                 780                 


Lys Ala Glu Asp Lys Gln Pro Pro Ala Gly Lys Lys His Ser Ser Glu 
785                 790                 795                 800 


Lys Arg Ser Ser Asp Ser Ser Ser Lys Leu Ala Lys Lys Arg Lys Gly 
                805                 810                 815     


Glu Ala Glu Arg Asp Cys Asp Asn Lys Lys Ile Arg Leu Glu Lys Glu 
            820                 825                 830         


Ile Lys Ser Gln Ser Ser Ser Ser Ser Ser Ser His Lys Glu Ser Ser 
        835                 840                 845             


Lys Xaa Lys Pro Ser Arg Pro Ser Ser Gln Ser Ser Lys Lys Glu Met 
    850                 855                 860                 


Leu Pro Pro Pro Pro Val Ser Ser Ser Ser Gln Lys Pro Ala Lys Pro 
865                 870                 875                 880 


Ala Leu Lys Arg Ser Arg Arg Glu Ala Asp Xaa Cys Gly Gln Asp Pro 
                885                 890                 895     


Pro Lys Ser Ala Ser Ser Xaa Lys Ser Asn His Lys Asp Ser Ser Ile 
            900                 905                 910         


Pro Lys Gln Arg Arg Val Glu Gly Lys Gly Ser Arg Ser Ser Ser Glu 
        915                 920                 925             


His Lys Gly Ser Ser Gly Asp Xaa Ala Asn Pro Phe Pro Val Pro Ser 
    930                 935                 940                 


Leu Pro Asn Gly Asn Ser Lys Pro Gly Lys Pro Gln Val Lys Phe Asp 
945                 950                 955                 960 


Lys Gln Gln Ala Asp Leu His Met Arg Glu Ala Lys Lys Met Lys Gln 
                965                 970                 975     


Lys Ala Glu Leu Met Xaa Asp Arg Val Gly Lys Ala Phe Lys Tyr Leu 
            980                 985                 990         


Glu Ala Val Leu Ser Phe Ile Glu  Cys Gly Ile Ala Xaa  Glu Ser Glu 
        995                 1000                 1005             


Ser Gln  Ser Ser Lys Ser Ala  Tyr Ser Val Tyr Ser  Glu Xaa Val 
    1010                 1015                 1020             


Asp Leu  Ile Lys Phe Ile Met  Ser Leu Lys Ser Phe  Ser Asp Ala 
    1025                 1030                 1035             


Xaa Ala  Pro Xaa Gln Glu Lys  Ile Phe Ala Val Leu  Cys Met Arg 
    1040                 1045                 1050             


Cys Gln  Ser Ile Leu Asn Met  Ala Met Phe Arg Cys  Lys Lys Asp 
    1055                 1060                 1065             


Ile Ala  Ile Lys Tyr Ser Arg  Xaa Leu Asn Lys His  Phe Glu Ser 
    1070                 1075                 1080             


Ser Ser  Lys Val Ala Gln Ala  Pro Ser Pro Cys Ile  Ala Ser Xaa 
    1085                 1090                 1095             


Gly Xaa  Pro Ser Pro Leu Ser  Pro Met Pro Ser Pro  Ala Ser Ser 
    1100                 1105                 1110             


Val Gly  Ser Gln Ser Ser Ala  Gly Ser Val Gly Ser  Ser Gly Val 
    1115                 1120                 1125             


Ala Ala  Xaa Ile Ser Xaa Pro  Val Xaa Ile Gln Asn  Met Xaa Ser 
    1130                 1135                 1140             


Ser Tyr  Val Xaa Ile Xaa Ser  His Val Leu Xaa Ala  Phe Asp Leu 
    1145                 1150                 1155             


Trp Glu  Gln Ala Glu Ala Leu  Xaa Arg Lys Asn Lys  Glu Phe Phe 
    1160                 1165                 1170             


Ala Arg  Leu Ser Xaa Asn Val  Cys Xaa Leu Ala Leu  Asn Ser Ser 
    1175                 1180                 1185             


Leu Val  Asp Leu Val His Tyr  Xaa Arg Gln Gly Phe  Gln Gln Leu 
    1190                 1195                 1200             


Gln Glu  Leu Xaa Lys Xaa Pro  
    1205                 1210 


<210> 1894
<211> 406
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<400> 1894
Met Ala Phe Xaa Glu Arg Val Asn Ser Ser Gly Asn Ser Leu Tyr Asn 
1               5                   10                  15      


Asp Asp Arg Asn Leu Leu Arg Ile Arg Glu Lys Glu Arg Arg Asn Gln 
            20                  25                  30          


Glu Ala His Gln Glu Lys Glu Ala Phe Pro Glu Lys Ile Pro Leu Phe 
        35                  40                  45              


Gly Glu Pro Tyr Lys Xaa Ala Lys Gly Asp Glu Leu Ser Ser Arg Ile 
    50                  55                  60                  


Gln Asn Met Leu Gly Asn Tyr Glu Glu Val Lys Glu Phe Leu Ser Xaa 
65                  70                  75                  80  


Lys Ser His Xaa His Arg Leu Asp Ala Ser Glu Asn Arg Leu Gly Lys 
                85                  90                  95      


Pro Lys Tyr Pro Leu Ile Pro Asp Lys Gly Ser Ser Ile Pro Ser Ser 
            100                 105                 110         


Ser Phe His Xaa Ser Val His His Gln Ser Ile His Xaa Pro Ala Ser 
        115                 120                 125             


Gly Pro Leu Ser Val Gly Asn Ile Ser His Asn Pro Lys Met Ala Gln 
    130                 135                 140                 


Pro Arg Xaa Glu Pro Met Pro Ser Leu His Ala Lys Ser Cys Gly Pro 
145                 150                 155                 160 


Pro Asp Ser Gln His Leu Xaa Gln Asp Arg Leu Gly Gln Glu Gly Phe 
                165                 170                 175     


Gly Ser Ser His His Lys Lys Gly Asp Arg Arg Ala Asp Gly Asp His 
            180                 185                 190         


Cys Ala Ser Val Xaa Asp Ser Ala Pro Glu Arg Glu Leu Ser Pro Leu 
        195                 200                 205             


Ile Ser Leu Pro Ser Pro Val Pro Pro Leu Ser Pro Ile His Ser Asn 
    210                 215                 220                 


Gln Gln Xaa Leu Pro Arg Xaa Gln Gly Ser Ser Lys Val His Gly Ser 
225                 230                 235                 240 


Ser Asn Asn Ser Lys Gly Tyr Cys Pro Ala Lys Ser Pro Lys Asp Leu 
                245                 250                 255     


Ala Val Lys Val His Asp Lys Glu Xaa Pro Gln Asp Ser Leu Val Ala 
            260                 265                 270         


Pro Ala Gln Pro Pro Ser Gln Xaa Phe Pro Pro Pro Ser Leu Pro Ser 
        275                 280                 285             


Lys Ser Val Ala Met Gln Gln Lys Pro Xaa Ala Tyr Val Arg Pro Met 
    290                 295                 300                 


Asp Gly Gln Asp Gln Ala Pro Ser Glu Ser Pro Glu Leu Lys Pro Leu 
305                 310                 315                 320 


Pro Glu Asp Tyr Arg Gln Gln Xaa Phe Glu Lys Xaa Asp Leu Lys Val 
                325                 330                 335     


Pro Ala Lys Ala Lys Leu Xaa Lys Leu Lys Met Pro Ser Gln Ser Val 
            340                 345                 350         


Glu Xaa Tyr Ser Asn Glu Val His Cys Val Glu Glu Ile Leu Lys Glu 
        355                 360                 365             


Met Xaa His Ser Trp Pro Pro Pro Leu Xaa Ala Ile His Xaa Pro Ser 
    370                 375                 380                 


Xaa Ala Glu Pro Ser Lys Phe Pro Phe Pro Xaa Lys Asp Ser Gln His 
385                 390                 395                 400 


Val Ser Ser Val Xaa Gln 
                405     


<210> 1895
<211> 417
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<400> 1895
Met Ala Phe Xaa Glu Arg Val Asn Ser Ser Gly Asn Ser Leu Tyr Asn 
1               5                   10                  15      


Asp Asp Arg Asn Leu Leu Arg Ile Arg Glu Lys Glu Arg Arg Asn Gln 
            20                  25                  30          


Glu Ala His Gln Glu Lys Glu Ala Phe Pro Glu Lys Ile Pro Leu Phe 
        35                  40                  45              


Gly Glu Pro Tyr Lys Xaa Ala Lys Gly Asp Glu Leu Ser Ser Arg Ile 
    50                  55                  60                  


Gln Asn Met Leu Gly Asn Tyr Glu Glu Val Lys Glu Phe Leu Ser Xaa 
65                  70                  75                  80  


Lys Ser His Xaa His Arg Leu Asp Ala Ser Glu Asn Arg Leu Gly Lys 
                85                  90                  95      


Pro Lys Tyr Pro Leu Ile Pro Asp Lys Gly Ser Ser Ile Pro Ser Ser 
            100                 105                 110         


Ser Phe His Xaa Ser Val His His Gln Ser Ile His Xaa Pro Ala Ser 
        115                 120                 125             


Gly Pro Leu Ser Val Gly Asn Ile Ser His Asn Pro Lys Met Ala Gln 
    130                 135                 140                 


Pro Arg Xaa Glu Pro Met Pro Ser Leu His Ala Lys Ser Cys Gly Pro 
145                 150                 155                 160 


Pro Asp Ser Gln His Leu Xaa Gln Asp Arg Leu Gly Gln Glu Gly Phe 
                165                 170                 175     


Gly Ser Ser His His Lys Lys Gly Asp Arg Arg Ala Asp Gly Asp His 
            180                 185                 190         


Cys Ala Ser Val Xaa Asp Ser Ala Pro Glu Arg Glu Leu Ser Pro Leu 
        195                 200                 205             


Ile Ser Leu Pro Ser Pro Val Pro Pro Leu Ser Pro Ile His Ser Asn 
    210                 215                 220                 


Gln Gln Xaa Leu Pro Arg Xaa Gln Gly Ser Ser Lys Val His Gly Ser 
225                 230                 235                 240 


Ser Asn Asn Ser Lys Gly Tyr Cys Pro Ala Lys Ser Pro Lys Asp Leu 
                245                 250                 255     


Ala Val Lys Val His Asp Lys Glu Xaa Pro Gln Asp Ser Leu Val Ala 
            260                 265                 270         


Pro Ala Gln Pro Pro Ser Gln Xaa Phe Pro Pro Pro Ser Leu Pro Ser 
        275                 280                 285             


Lys Ser Val Ala Met Gln Gln Lys Pro Xaa Ala Tyr Val Arg Pro Met 
    290                 295                 300                 


Asp Gly Gln Asp Gln Ala Pro Ser Glu Ser Pro Glu Leu Lys Pro Leu 
305                 310                 315                 320 


Pro Glu Asp Tyr Arg Gln Gln Xaa Phe Glu Lys Xaa Asp Leu Lys Val 
                325                 330                 335     


Pro Ala Lys Ala Lys Leu Xaa Lys Leu Lys Met Pro Ser Gln Ser Val 
            340                 345                 350         


Glu Gln Xaa Tyr Ser Asn Glu Val His Cys Val Glu Glu Ile Leu Lys 
        355                 360                 365             


Asp Ser Gln His Val Ser Ser Val Xaa Gln Asn Gln Lys Gln Tyr Asp 
    370                 375                 380                 


Xaa Ser Ser Lys Xaa His Ser Asn Ser Gln Gln Gly Xaa Ser Ser Met 
385                 390                 395                 400 


Leu Glu Asp Asp Leu Gln Leu Ser Asp Ser Glu Asp Ser Asp Ser Glu 
                405                 410                 415     


Gln 
    


<210> 1896
<211> 1218
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1083)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1106)..(1106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1108)..(1108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1145)..(1145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1190)..(1190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Selenocysteine

<400> 1896
Met Ala Phe Xaa Glu Arg Val Asn Ser Ser Gly Asn Ser Leu Tyr Asn 
1               5                   10                  15      


Asp Asp Arg Asn Leu Leu Arg Ile Arg Glu Lys Glu Arg Arg Asn Gln 
            20                  25                  30          


Glu Ala His Gln Glu Lys Glu Ala Phe Pro Glu Lys Ile Pro Leu Phe 
        35                  40                  45              


Gly Glu Pro Tyr Lys Xaa Ala Lys Gly Asp Glu Leu Ser Ser Arg Ile 
    50                  55                  60                  


Gln Asn Met Leu Gly Asn Tyr Glu Glu Val Lys Glu Phe Leu Ser Xaa 
65                  70                  75                  80  


Lys Ser His Xaa His Arg Leu Asp Ala Ser Glu Asn Arg Leu Gly Lys 
                85                  90                  95      


Pro Lys Tyr Pro Leu Ile Pro Asp Lys Gly Ser Ser Ile Pro Ser Ser 
            100                 105                 110         


Ser Phe His Xaa Ser Val His His Gln Ser Ile His Xaa Pro Ala Ser 
        115                 120                 125             


Gly Pro Leu Ser Val Gly Asn Ile Ser His Asn Pro Lys Met Ala Gln 
    130                 135                 140                 


Pro Arg Xaa Glu Pro Met Pro Ser Leu His Ala Lys Ser Cys Gly Pro 
145                 150                 155                 160 


Pro Asp Ser Gln His Leu Xaa Gln Asp Arg Leu Gly Gln Glu Gly Phe 
                165                 170                 175     


Gly Ser Ser His His Lys Lys Gly Asp Arg Arg Ala Asp Gly Asp His 
            180                 185                 190         


Cys Ala Ser Val Xaa Asp Ser Ala Pro Glu Arg Glu Leu Ser Pro Leu 
        195                 200                 205             


Ile Ser Leu Pro Ser Pro Val Pro Pro Leu Ser Pro Ile His Ser Asn 
    210                 215                 220                 


Gln Gln Xaa Leu Pro Arg Xaa Gln Gly Ser Ser Lys Val His Gly Ser 
225                 230                 235                 240 


Ser Asn Asn Ser Lys Gly Tyr Cys Pro Ala Lys Ser Pro Lys Asp Leu 
                245                 250                 255     


Ala Val Lys Val His Asp Lys Glu Xaa Pro Gln Asp Ser Leu Val Ala 
            260                 265                 270         


Pro Ala Gln Pro Pro Ser Gln Xaa Phe Pro Pro Pro Ser Leu Pro Ser 
        275                 280                 285             


Lys Ser Val Ala Met Gln Gln Lys Pro Xaa Ala Tyr Val Arg Pro Met 
    290                 295                 300                 


Asp Gly Gln Asp Gln Ala Pro Ser Glu Ser Pro Glu Leu Lys Pro Leu 
305                 310                 315                 320 


Pro Glu Asp Tyr Arg Gln Gln Xaa Phe Glu Lys Xaa Asp Leu Lys Val 
                325                 330                 335     


Pro Ala Lys Ala Lys Leu Xaa Lys Leu Lys Met Pro Ser Gln Ser Val 
            340                 345                 350         


Glu Gln Xaa Tyr Ser Asn Glu Val His Cys Val Glu Glu Ile Leu Lys 
        355                 360                 365             


Glu Met Xaa His Ser Trp Pro Pro Pro Leu Xaa Ala Ile His Xaa Pro 
    370                 375                 380                 


Ser Xaa Ala Glu Pro Ser Lys Phe Pro Phe Pro Xaa Lys Asp Ser Gln 
385                 390                 395                 400 


His Val Ser Ser Val Xaa Gln Asn Gln Lys Gln Tyr Asp Xaa Ser Ser 
                405                 410                 415     


Lys Xaa His Ser Asn Ser Gln Gln Gly Xaa Ser Ser Met Leu Glu Asp 
            420                 425                 430         


Asp Leu Gln Leu Ser Asp Ser Glu Asp Ser Asp Ser Glu Gln Xaa Pro 
        435                 440                 445             


Glu Lys Pro Pro Ser Ser Ser Ala Pro Pro Ser Ala Pro Gln Ser Leu 
    450                 455                 460                 


Pro Glu Pro Val Ala Ser Ala His Ser Ser Ser Ala Glu Ser Glu Ser 
465                 470                 475                 480 


Xaa Ser Asp Ser Asp Ser Ser Ser Asp Ser Glu Ser Glu Ser Ser Ser 
                485                 490                 495     


Ser Asp Ser Glu Glu Asn Glu Pro Leu Glu Xaa Pro Ala Pro Glu Pro 
            500                 505                 510         


Glu Pro Pro Xaa Xaa Asn Lys Trp Gln Leu Asp Asn Trp Leu Xaa Lys 
        515                 520                 525             


Val Ser Gln Pro Ala Ala Pro Pro Glu Gly Pro Arg Ser Xaa Glu Pro 
    530                 535                 540                 


Pro Arg Arg His Pro Glu Ser Lys Gly Ser Ser Asp Ser Ala Xaa Ser 
545                 550                 555                 560 


Gln Glu His Ser Glu Ser Lys Asp Pro Pro Pro Lys Ser Ser Ser Lys 
                565                 570                 575     


Ala Pro Arg Ala Pro Pro Glu Ala Pro His Pro Gly Lys Arg Ser Cys 
            580                 585                 590         


Gln Lys Ser Pro Ala Gln Gln Glu Pro Pro Gln Arg Gln Xaa Val Gly 
        595                 600                 605             


Xaa Lys Gln Pro Lys Lys Pro Val Lys Ala Ser Ala Arg Ala Gly Ser 
    610                 615                 620                 


Arg Xaa Ser Leu Gln Gly Glu Arg Glu Pro Gly Leu Leu Pro Tyr Gly 
625                 630                 635                 640 


Ser Arg Asp Gln Xaa Ser Lys Asp Lys Pro Lys Val Lys Xaa Lys Gly 
                645                 650                 655     


Arg Pro Arg Ala Ala Ala Ser Asn Glu Pro Lys Pro Ala Val Pro Pro 
            660                 665                 670         


Ser Ser Glu Lys Lys Lys His Lys Ser Ser Leu Pro Ala Pro Ser Lys 
        675                 680                 685             


Ala Leu Ser Gly Pro Glu Pro Ala Lys Asp Asn Val Glu Asp Arg Xaa 
    690                 695                 700                 


Pro Glu His Phe Ala Leu Val Pro Leu Xaa Glu Ser Gln Gly Pro Pro 
705                 710                 715                 720 


His Ser Gly Ser Gly Ser Arg Xaa Ser Gly Cys Arg Gln Ala Val Val 
                725                 730                 735     


Val Gln Glu Asp Ser Arg Lys Asp Arg Leu Pro Leu Pro Leu Arg Asp 
            740                 745                 750         


Xaa Lys Leu Leu Ser Pro Leu Arg Asp Xaa Pro Pro Pro Gln Ser Leu 
        755                 760                 765             


Met Val Lys Ile Xaa Leu Asp Leu Leu Ser Arg Ile Pro Gln Pro Pro 
    770                 775                 780                 


Gly Lys Gly Ser Arg Gln Arg Lys Ala Glu Asp Lys Gln Pro Pro Ala 
785                 790                 795                 800 


Gly Lys Lys His Ser Ser Glu Lys Arg Ser Ser Asp Ser Ser Ser Lys 
                805                 810                 815     


Leu Ala Lys Lys Arg Lys Gly Glu Ala Glu Arg Asp Cys Asp Asn Lys 
            820                 825                 830         


Lys Ile Arg Leu Glu Lys Glu Ile Lys Ser Gln Ser Ser Ser Ser Ser 
        835                 840                 845             


Ser Ser His Lys Glu Ser Ser Lys Xaa Lys Pro Ser Arg Pro Ser Ser 
    850                 855                 860                 


Gln Ser Ser Lys Lys Glu Met Leu Pro Pro Pro Pro Val Ser Ser Ser 
865                 870                 875                 880 


Ser Gln Lys Pro Ala Lys Pro Ala Leu Lys Arg Ser Arg Arg Glu Ala 
                885                 890                 895     


Asp Xaa Cys Gly Gln Asp Pro Pro Lys Ser Ala Ser Ser Xaa Lys Ser 
            900                 905                 910         


Asn His Lys Asp Ser Ser Ile Pro Lys Gln Arg Arg Val Glu Gly Lys 
        915                 920                 925             


Gly Ser Arg Ser Ser Ser Glu His Lys Gly Ser Ser Gly Asp Xaa Ala 
    930                 935                 940                 


Asn Pro Phe Pro Val Pro Ser Leu Pro Asn Gly Asn Ser Lys Pro Gly 
945                 950                 955                 960 


Lys Pro Gln Val Lys Phe Asp Lys Gln Gln Ala Asp Leu His Met Arg 
                965                 970                 975     


Glu Ala Lys Lys Met Lys Gln Lys Ala Glu Leu Met Xaa Asp Arg Val 
            980                 985                 990         


Gly Lys Ala Phe Lys Tyr Leu Glu  Ala Val Leu Ser Phe  Ile Glu Cys 
        995                 1000                 1005             


Gly Ile  Ala Xaa Glu Ser Glu  Ser Gln Ser Ser Lys  Ser Ala Tyr 
    1010                 1015                 1020             


Ser Val  Tyr Ser Glu Xaa Val  Asp Leu Ile Lys Phe  Ile Met Ser 
    1025                 1030                 1035             


Leu Lys  Ser Phe Ser Asp Ala  Xaa Ala Pro Xaa Gln  Glu Lys Ile 
    1040                 1045                 1050             


Phe Ala  Val Leu Cys Met Arg  Cys Gln Ser Ile Leu  Asn Met Ala 
    1055                 1060                 1065             


Met Phe  Arg Cys Lys Lys Asp  Ile Ala Ile Lys Tyr  Ser Arg Xaa 
    1070                 1075                 1080             


Leu Asn  Lys His Phe Glu Ser  Ser Ser Lys Val Ala  Gln Ala Pro 
    1085                 1090                 1095             


Ser Pro  Cys Ile Ala Arg Ser  Xaa Gly Xaa Pro Ser  Pro Leu Ser 
    1100                 1105                 1110             


Pro Met  Pro Ser Pro Ala Ser  Ser Val Gly Ser Gln  Ser Ser Ala 
    1115                 1120                 1125             


Gly Ser  Val Gly Ser Ser Gly  Val Ala Ala Xaa Ile  Ser Xaa Pro 
    1130                 1135                 1140             


Val Xaa  Ile Gln Asn Met Xaa  Ser Ser Tyr Val Xaa  Ile Xaa Ser 
    1145                 1150                 1155             


His Val  Leu Xaa Ala Phe Asp  Leu Trp Glu Gln Ala  Glu Ala Leu 
    1160                 1165                 1170             


Xaa Arg  Lys Asn Lys Glu Phe  Phe Ala Arg Leu Ser  Xaa Asn Val 
    1175                 1180                 1185             


Cys Xaa  Leu Ala Leu Asn Ser  Ser Leu Val Asp Leu  Val His Tyr 
    1190                 1195                 1200             


Xaa Arg  Gln Gly Phe Gln Gln  Leu Gln Glu Leu Xaa  Lys Xaa Pro 
    1205                 1210                 1215             


<210> 1897
<211> 52
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 1897
Met Leu Gly Asn Tyr Glu Glu Val Lys Glu Phe Leu Ser Xaa Lys Ser 
1               5                   10                  15      


His Xaa His Arg Leu Asp Ala Ser Glu Asn Arg Leu Gly Lys Pro Lys 
            20                  25                  30          


Tyr Pro Leu Ile Pro Asp Lys Gly Ser Ser Ile Pro Ser Ser Ser Phe 
        35                  40                  45              


His Xaa Ser Val 
    50          


<210> 1898
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<400> 1898
Met Xaa His Ser Trp Pro Pro Pro Leu Xaa Ala Ile His Xaa Pro Ser 
1               5                   10                  15      


Xaa Ala Glu Pro Ser Lys Phe Pro Phe Pro Xaa Lys Asp Ser Gln His 
            20                  25                  30          


Val Ser Ser Val Xaa Gln Asn Gln Lys Gln Tyr Asp Xaa Ser Ser Lys 
        35                  40                  45              


Xaa His Ser Asn Ser Gln Gln Gly Xaa Ser Ser Met Leu Glu Asp Asp 
    50                  55                  60                  


Leu Gln Leu Ser Asp Ser Glu Asp Ser Asp Ser Glu Gln Xaa Pro Glu 
65                  70                  75                  80  


Lys Pro Pro Ser Ser Ser Ala Pro Pro Ser Ala Pro Gln Ser Leu Pro 
                85                  90                  95      


Glu Pro Val Ala Ser Ala His Ser Ser Ser Ala Glu Ser Glu Ser Xaa 
            100                 105                 110         


Ser Asp Ser Asp Ser Ser Ser Asp Ser Glu Ser Glu Ser Ser Ser Ser 
        115                 120                 125             


Asp Ser Glu Glu Asn Glu Pro Leu Glu 
    130                 135         


<210> 1899
<211> 194
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<400> 1899
Xaa Val Ser Ile Ser Phe Asn Ala Val Val Pro Ser Gly Leu Gly Pro 
1               5                   10                  15      


Ser Ser His Ala Arg Gln Arg Gln Leu Trp Tyr Gln Leu Pro Gly Ser 
            20                  25                  30          


Pro Val Ala Leu Leu Gln Xaa Tyr Ser Asn Glu Val His Cys Val Glu 
        35                  40                  45              


Glu Ile Leu Lys Glu Met Xaa His Ser Trp Pro Pro Pro Leu Xaa Ala 
    50                  55                  60                  


Ile His Xaa Pro Ser Xaa Ala Glu Pro Ser Lys Phe Pro Phe Pro Xaa 
65                  70                  75                  80  


Lys Asp Ser Gln His Val Ser Ser Val Xaa Gln Asn Gln Lys Gln Tyr 
                85                  90                  95      


Asp Xaa Ser Ser Lys Xaa His Ser Asn Ser Gln Gln Gly Xaa Ser Ser 
            100                 105                 110         


Met Leu Glu Asp Asp Leu Gln Leu Ser Asp Ser Glu Asp Ser Asp Ser 
        115                 120                 125             


Glu Gln Xaa Pro Glu Lys Pro Pro Ser Ser Ser Ala Pro Pro Ser Ala 
    130                 135                 140                 


Pro Gln Ser Leu Pro Glu Pro Val Ala Ser Ala His Ser Ser Ser Ala 
145                 150                 155                 160 


Glu Ser Glu Ser Xaa Ser Asp Ser Asp Ser Ser Ser Asp Ser Glu Ser 
                165                 170                 175     


Glu Ser Ser Ser Ser Asp Ser Glu Glu Asn Glu Pro Leu Glu Xaa Pro 
            180                 185                 190         


Ala Pro 
        


<210> 1900
<211> 427
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<400> 1900
Met Asp Leu Phe Asp Phe Phe Arg Asp Trp Asp Leu Glu Gln Gln Cys 
1               5                   10                  15      


His Tyr Glu Gln Asp Arg Ser Ala Leu Lys Lys Arg Glu Trp Glu Arg 
            20                  25                  30          


Arg Asn Gln Glu Val Gln Gln Glu Asp Asp Leu Phe Ser Ser Gly Phe 
        35                  40                  45              


Asp Leu Phe Gly Glu Pro Tyr Lys Xaa Asn Lys Gly Asp Ala Leu Ala 
    50                  55                  60                  


Asn Arg Val Gln Asn Xaa Leu Gly Asn Tyr Asp Glu Met Lys Asn Leu 
65                  70                  75                  80  


Leu Xaa Asn His Ser Asn Gln Asn His Leu Val Gly Ile Pro Lys Asn 
                85                  90                  95      


Ser Val Pro Gln Asn Pro Asn Asn Lys Asn Glu Pro Ser Phe Phe Pro 
            100                 105                 110         


Glu Gln Lys Asn Arg Ile Ile Pro Pro His Gln Asp Asn Xaa His Pro 
        115                 120                 125             


Ser Ala Pro Met Pro Pro Pro Ser Val Val Ile Leu Asn Ser Xaa Leu 
    130                 135                 140                 


Ile His Ser Asn Arg Lys Ser Lys Pro Glu Trp Ser Arg Asp Ser His 
145                 150                 155                 160 


Asn Pro Ser Xaa Val Leu Ala Ser Gln Ala Ser Gly Gln Pro Asn Lys 
                165                 170                 175     


Met Gln Xaa Leu Xaa Gln Asp Gln Ser Gln Ala Lys Leu Glu Asp Phe 
            180                 185                 190         


Phe Val Tyr Pro Ala Glu Gln Pro Gln Ile Gly Glu Val Glu Glu Ser 
        195                 200                 205             


Asn Pro Ser Ala Lys Glu Asp Ser Asn Pro Asn Ser Ser Gly Glu Asp 
    210                 215                 220                 


Ala Phe Lys Glu Ile Phe Gln Ser Asn Ser Pro Glu Glu Ser Glu Phe 
225                 230                 235                 240 


Ala Val Gln Ala Pro Gly Ser Pro Leu Val Ala Ser Ser Leu Leu Ala 
                245                 250                 255     


Pro Ser Ser Gly Leu Ser Val Gln Asn Phe Pro Pro Gly Leu Tyr Cys 
            260                 265                 270         


Lys Xaa Ser Met Gly Gln Gln Lys Pro Xaa Ala Tyr Val Arg Pro Met 
        275                 280                 285             


Asp Gly Gln Asp Gln Ala Pro Asp Ile Ser Pro Xaa Leu Lys Pro Ser 
    290                 295                 300                 


Ile Glu Phe Glu Asn Ser Phe Gly Asn Leu Ser Phe Gly Xaa Leu Leu 
305                 310                 315                 320 


Asp Gly Lys Pro Ser Ala Ala Ser Ser Lys Xaa Lys Leu Pro Lys Phe 
                325                 330                 335     


Xaa Ile Leu Gln Xaa Ser Glu Val Ser Leu Pro Ser Asp Pro Ser Cys 
            340                 345                 350         


Val Glu Glu Ile Leu Arg Glu Ser Gln His Leu Xaa Pro Gly Phe Xaa 
        355                 360                 365             


Leu Gln Lys Trp Asn Asp Pro Xaa Xaa Arg Ala Ser Xaa Lys Met Leu 
    370                 375                 380                 


Glu Asp Asp Leu Lys Leu Ser Ser Asp Glu Asp Asp Leu Glu Pro Val 
385                 390                 395                 400 


Lys Xaa Leu Xaa Xaa Gln Cys Xaa Ala Xaa Glu Leu Tyr Gln Ala Val 
                405                 410                 415     


Glu Lys Ala Lys Pro Arg Asn Asn Pro Val Lys 
            420                 425         


<210> 1901
<211> 1276
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (996)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1244)..(1244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<400> 1901
Met Asp Leu Phe Asp Phe Phe Arg Asp Trp Asp Leu Glu Gln Gln Cys 
1               5                   10                  15      


His Tyr Glu Gln Asp Arg Ser Ala Leu Lys Lys Arg Glu Trp Glu Arg 
            20                  25                  30          


Arg Asn Gln Glu Val Gln Gln Glu Asp Asp Leu Phe Ser Ser Gly Phe 
        35                  40                  45              


Asp Leu Phe Gly Glu Pro Tyr Lys Xaa Asn Lys Gly Asp Ala Leu Ala 
    50                  55                  60                  


Asn Arg Val Gln Asn Xaa Leu Gly Asn Tyr Asp Glu Met Lys Asn Leu 
65                  70                  75                  80  


Leu Xaa Asn His Ser Asn Gln Asn His Leu Val Gly Ile Pro Lys Asn 
                85                  90                  95      


Ser Val Pro Gln Asn Pro Asn Asn Lys Asn Glu Pro Ser Phe Phe Pro 
            100                 105                 110         


Glu Gln Lys Asn Arg Ile Ile Pro Pro His Gln Asp Asn Xaa His Pro 
        115                 120                 125             


Ser Ala Pro Met Pro Pro Pro Ser Val Val Ile Leu Asn Ser Xaa Leu 
    130                 135                 140                 


Ile His Ser Asn Arg Lys Ser Lys Pro Glu Trp Ser Arg Asp Ser His 
145                 150                 155                 160 


Asn Pro Ser Xaa Val Leu Ala Ser Gln Ala Ser Gly Gln Pro Asn Lys 
                165                 170                 175     


Met Gln Xaa Leu Xaa Gln Asp Gln Ser Gln Ala Lys Leu Glu Asp Phe 
            180                 185                 190         


Phe Val Tyr Pro Ala Glu Gln Pro Gln Ile Gly Glu Val Glu Glu Ser 
        195                 200                 205             


Asn Pro Ser Ala Lys Glu Asp Ser Asn Pro Asn Ser Ser Gly Glu Asp 
    210                 215                 220                 


Ala Phe Lys Glu Ile Phe Gln Ser Asn Ser Pro Glu Glu Ser Glu Phe 
225                 230                 235                 240 


Ala Val Gln Ala Pro Gly Ser Pro Leu Val Ala Ser Ser Leu Leu Ala 
                245                 250                 255     


Pro Ser Ser Gly Leu Ser Val Gln Asn Phe Pro Pro Gly Leu Tyr Cys 
            260                 265                 270         


Lys Xaa Ser Met Gly Gln Gln Lys Pro Xaa Ala Tyr Val Arg Pro Met 
        275                 280                 285             


Asp Gly Gln Asp Gln Ala Pro Asp Ile Ser Pro Xaa Leu Lys Pro Ser 
    290                 295                 300                 


Ile Glu Phe Glu Asn Ser Phe Gly Asn Leu Ser Phe Gly Xaa Leu Leu 
305                 310                 315                 320 


Asp Gly Lys Pro Ser Ala Ala Ser Ser Lys Xaa Lys Leu Pro Lys Phe 
                325                 330                 335     


Xaa Ile Leu Gln Xaa Ser Glu Val Ser Leu Pro Ser Asp Pro Ser Cys 
            340                 345                 350         


Val Glu Glu Ile Leu Arg Glu Ser Gln His Leu Xaa Pro Gly Phe Xaa 
        355                 360                 365             


Leu Gln Lys Trp Asn Asp Pro Xaa Xaa Arg Ala Ser Xaa Lys Ser Val 
    370                 375                 380                 


Ser Phe Lys Ser Met Leu Glu Asp Asp Leu Lys Leu Ser Ser Asp Glu 
385                 390                 395                 400 


Asp Asp Leu Glu Pro Val Lys Xaa Leu Xaa Xaa Gln Cys Xaa Ala Xaa 
                405                 410                 415     


Glu Leu Tyr Gln Ala Val Glu Lys Ala Lys Pro Arg Asn Asn Pro Val 
            420                 425                 430         


Asn Pro Pro Leu Ala Xaa Pro Gln Pro Pro Pro Ala Val Gln Ala Ser 
        435                 440                 445             


Gly Gly Ser Gly Ser Ser Ser Glu Ser Glu Ser Ser Ser Glu Ser Asp 
    450                 455                 460                 


Ser Asp Xaa Glu Ser Ser Xaa Xaa Asp Ser Glu Ser Asn Glu Ala Pro 
465                 470                 475                 480 


Arg Val Ala Xaa Pro Glu Pro Glu Pro Pro Ser Xaa Asn Lys Trp Gln 
                485                 490                 495     


Leu Asp Lys Trp Leu Asn Lys Val Xaa Ser Gln Asn Lys Ser Phe Ile 
            500                 505                 510         


Cys Gly Gln Asn Glu Xaa Pro Met Glu Xaa Ile Ser Leu Pro Pro Pro 
        515                 520                 525             


Ile Ile Gln Pro Met Glu Val Gln Met Lys Val Lys Xaa Asn Ala Ser 
    530                 535                 540                 


Gln Val Pro Ala Glu Pro Lys Glu Arg Pro Leu Leu Ser Leu Ile Arg 
545                 550                 555                 560 


Glu Lys Ala Arg Pro Arg Pro Xaa Gln Lys Ile Pro Glu Xaa Lys Ala 
                565                 570                 575     


Leu Lys His Lys Leu Ser Xaa Xaa Ser Glu Xaa Val Ser Gln Arg Xaa 
            580                 585                 590         


Ile Gly Lys Lys Gln Pro Lys Lys Val Glu Lys Asn Xaa Ser Xaa Asp 
        595                 600                 605             


Glu Phe Xaa Trp Pro Lys Pro Asn Ile Xaa Ser Ser Xaa Pro Lys Glu 
    610                 615                 620                 


Lys Glu Ser Val Glu Leu His Asp Pro Pro Arg Gly Arg Asn Lys Ala 
625                 630                 635                 640 


Xaa Ala His Lys Pro Ala Pro Arg Lys Glu Pro Arg Pro Asn Ile Pro 
                645                 650                 655     


Leu Ala Pro Glu Lys Lys Lys Tyr Arg Gly Pro Gly Lys Ile Val Pro 
            660                 665                 670         


Lys Ser Arg Glu Phe Ile Glu Xaa Asp Ser Ser Xaa Ser Asp Ser Asn 
        675                 680                 685             


Xaa Asp Gln Glu Glu Xaa Leu Gln Ile Lys Val Leu Pro Pro Cys Ile 
    690                 695                 700                 


Ile Ser Gly Gly Asn Xaa Ala Lys Ser Lys Glu Ile Cys Gly Ala Ser 
705                 710                 715                 720 


Leu Xaa Leu Ser Xaa Leu Met Ser Ser Ser Gly Ser Asn Asn Asn Leu 
                725                 730                 735     


Ser Ile Ser Asn Glu Glu Pro Xaa Phe Ser Pro Ile Pro Val Met Gln 
            740                 745                 750         


Xaa Glu Ile Leu Ser Pro Leu Arg Asp His Glu Asn Leu Lys Asn Leu 
        755                 760                 765             


Trp Val Lys Ile Asp Leu Asp Leu Leu Ser Arg Val Pro Gly His Ser 
    770                 775                 780                 


Ser Leu His Ala Ala Pro Ala Lys Pro Asp His Lys Glu Xaa Ala Xaa 
785                 790                 795                 800 


Lys Pro Lys Arg Gln Xaa Ala Val Xaa Ala Val Glu Lys Pro Ala Pro 
                805                 810                 815     


Lys Gly Lys Arg Lys His Lys Pro Ile Glu Val Ala Glu Lys Ile Pro 
            820                 825                 830         


Glu Lys Lys Gln Arg Leu Glu Glu Ala Xaa Xaa Ile Cys Leu Leu Pro 
        835                 840                 845             


Pro Cys Ile Ser Pro Ala Pro Pro His Lys Pro Pro Asn Xaa Arg Glu 
    850                 855                 860                 


Asn Asn Ser Ser Arg Arg Ala Asn Arg Arg Lys Glu Glu Lys Leu Phe 
865                 870                 875                 880 


Pro Pro Pro Leu Ser Pro Leu Pro Glu Asp Pro Pro Arg Arg Arg Asn 
                885                 890                 895     


Val Ser Gly Asn Asn Gly Pro Phe Gly Gln Asp Lys Asn Ile Ala Met 
            900                 905                 910         


Xaa Gly Gln Ile Xaa Ser Xaa Lys Pro Lys Arg Xaa Glu Gly Lys Phe 
        915                 920                 925             


Cys Ala Xaa Phe Lys Gly Ile Ser Glu Gly Asp Xaa Pro Lys Lys Ala 
    930                 935                 940                 


Ser Ser Ala Xaa Ile Xaa Val Xaa Asn Xaa Ala Ile Ala Xaa Ala Xaa 
945                 950                 955                 960 


Val Xaa Ala Xaa Ala Ile Val Xaa Xaa Xaa Val Xaa Ala Xaa Ala Xaa 
                965                 970                 975     


Ala Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Ser Xaa Ile Xaa 
            980                 985                 990         


Ser Xaa Ile Xaa Xaa Gly Leu Met  Asp Ser Ser His Leu  Glu Met Xaa 
        995                 1000                 1005             


Ser Trp  Ala Ala Leu Pro Leu  Leu Ser Ser Ser Ser  Xaa Asn Val 
    1010                 1015                 1020             


Arg Arg  Pro Lys Leu Xaa Phe  Asp Asp Ser Val His  Asn Ala Asp 
    1025                 1030                 1035             


Tyr Tyr  Met Gln Glu Ala Lys  Lys Leu Lys His Lys  Ala Asp Ala 
    1040                 1045                 1050             


Leu Phe  Glu Lys Phe Gly Lys  Ala Val Asn Tyr Ala  Asp Ala Ala 
    1055                 1060                 1065             


Leu Ser  Phe Xaa Glu Cys Gly  Asn Ala Met Glu Arg  Asp Pro Leu 
    1070                 1075                 1080             


Glu Ala  Lys Ser Pro Tyr Xaa  Met Tyr Ser Glu Xaa  Val Glu Leu 
    1085                 1090                 1095             


Leu Arg  Tyr Ala Met Arg Leu  Lys Asn Phe Ala Ser  Pro Leu Ala 
    1100                 1105                 1110             


Ser Asp  Gly Asp Lys Lys Leu  Ala Val Leu Cys Tyr  Arg Cys Leu 
    1115                 1120                 1125             


Ser Leu  Leu Tyr Leu Arg Met  Phe Lys Leu Lys Lys  Asp His Ala 
    1130                 1135                 1140             


Met Lys  Tyr Ser Arg Ser Leu  Met Glu Tyr Phe Lys  Gln Asn Ala 
    1145                 1150                 1155             


Ser Lys  Val Ala Gln Ile Pro  Ser Pro Trp Val Ser  Asn Gly Lys 
    1160                 1165                 1170             


Asn Xaa  Pro Ser Pro Val Ser  Leu Asn Asn Val Ser  Pro Ile Asn 
    1175                 1180                 1185             


Ala Met  Gly Asn Cys Asn Asn  Gly Pro Val Xaa Ile  Pro Gln Arg 
    1190                 1195                 1200             


Ile His  His Met Ala Ala Ser  His Val Asn Ile Xaa  Ser Asn Val 
    1205                 1210                 1215             


Leu Arg  Gly Tyr Glu His Trp  Asp Met Ala Asp Lys  Leu Xaa Arg 
    1220                 1225                 1230             


Glu Asn  Lys Glu Phe Phe Gly  Asp Leu Asp Xaa Leu  Met Gly Pro 
    1235                 1240                 1245             


Leu Xaa  Gln His Ser Ser Met  Xaa Asn Leu Val Arg  Tyr Val Arg 
    1250                 1255                 1260             


Gln Gly  Leu Cys Trp Leu Arg  Ile Asp Ala His Leu  Leu 
    1265                 1270                 1275     


<210> 1902
<211> 1276
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (996)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1244)..(1244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<400> 1902
Met Asp Leu Phe Asp Phe Phe Arg Asp Trp Asp Leu Glu Gln Gln Cys 
1               5                   10                  15      


His Tyr Glu Gln Asp Arg Ser Ala Leu Lys Lys Arg Glu Trp Glu Arg 
            20                  25                  30          


Arg Asn Gln Glu Val Gln Gln Glu Asp Asp Leu Phe Ser Ser Gly Phe 
        35                  40                  45              


Asp Leu Phe Gly Glu Pro Tyr Lys Val Ala Glu Tyr Xaa Asn Lys Gly 
    50                  55                  60                  


Asp Ala Leu Ala Asn Arg Val Gln Asn Xaa Leu Gly Asn Tyr Asp Glu 
65                  70                  75                  80  


Met Lys Asn Leu Leu Xaa Asn His Ser Asn Gln Asn His Leu Val Gly 
                85                  90                  95      


Ile Pro Lys Asn Ser Val Pro Gln Asn Pro Asn Asn Lys Asn Glu Pro 
            100                 105                 110         


Ser Phe Phe Pro Glu Gln Lys Asn Arg Ile Ile Pro Pro His Gln Asp 
        115                 120                 125             


Asn Xaa His Pro Ser Ala Pro Met Pro Pro Pro Ser Val Val Ile Leu 
    130                 135                 140                 


Asn Ser Xaa Leu Ile His Ser Asn Arg Lys Ser Lys Pro Glu Trp Ser 
145                 150                 155                 160 


Arg Asp Ser His Asn Pro Ser Xaa Val Leu Ala Ser Gln Ala Ser Gly 
                165                 170                 175     


Gln Pro Asn Lys Met Gln Xaa Leu Xaa Gln Asp Gln Ser Gln Ala Lys 
            180                 185                 190         


Leu Glu Asp Phe Phe Val Tyr Pro Ala Glu Gln Pro Gln Ile Gly Glu 
        195                 200                 205             


Val Glu Glu Ser Asn Pro Ser Ala Lys Glu Asp Ser Asn Pro Asn Ser 
    210                 215                 220                 


Ser Gly Glu Asp Ala Phe Lys Glu Ile Phe Gln Ser Asn Ser Pro Glu 
225                 230                 235                 240 


Glu Ser Glu Phe Ala Val Gln Ala Pro Gly Ser Pro Leu Val Ala Ser 
                245                 250                 255     


Ser Leu Leu Ala Pro Ser Ser Gly Leu Ser Val Gln Asn Phe Pro Pro 
            260                 265                 270         


Gly Leu Tyr Cys Lys Xaa Ser Met Gly Gln Gln Lys Pro Xaa Ala Tyr 
        275                 280                 285             


Val Arg Pro Met Asp Gly Gln Asp Gln Ala Pro Asp Ile Ser Pro Xaa 
    290                 295                 300                 


Leu Lys Pro Ser Ile Glu Phe Glu Asn Ser Phe Gly Asn Leu Ser Phe 
305                 310                 315                 320 


Gly Xaa Leu Leu Asp Gly Lys Pro Ser Ala Ala Ser Ser Lys Xaa Lys 
                325                 330                 335     


Leu Pro Lys Phe Xaa Ile Leu Gln Xaa Ser Glu Val Ser Leu Pro Ser 
            340                 345                 350         


Asp Pro Ser Cys Val Glu Glu Ile Leu Arg Glu Ser Gln His Leu Xaa 
        355                 360                 365             


Pro Gly Phe Xaa Leu Gln Lys Trp Asn Asp Pro Xaa Xaa Arg Ala Ser 
    370                 375                 380                 


Xaa Lys Met Leu Glu Asp Asp Leu Lys Leu Ser Ser Asp Glu Asp Asp 
385                 390                 395                 400 


Leu Glu Pro Val Lys Xaa Leu Xaa Xaa Gln Cys Xaa Ala Xaa Glu Leu 
                405                 410                 415     


Tyr Gln Ala Val Glu Lys Ala Lys Pro Arg Asn Asn Pro Val Asn Pro 
            420                 425                 430         


Pro Leu Ala Xaa Pro Gln Pro Pro Pro Ala Val Gln Ala Ser Gly Gly 
        435                 440                 445             


Ser Gly Ser Ser Ser Glu Ser Glu Ser Ser Ser Glu Ser Asp Ser Asp 
    450                 455                 460                 


Xaa Glu Ser Ser Xaa Xaa Asp Ser Glu Ser Asn Glu Ala Pro Arg Val 
465                 470                 475                 480 


Ala Xaa Pro Glu Pro Glu Pro Pro Ser Xaa Asn Lys Trp Gln Leu Asp 
                485                 490                 495     


Lys Trp Leu Asn Lys Val Xaa Ser Gln Asn Lys Ser Phe Ile Cys Gly 
            500                 505                 510         


Gln Asn Glu Xaa Pro Met Glu Xaa Ile Ser Leu Pro Pro Pro Ile Ile 
        515                 520                 525             


Gln Pro Met Glu Val Gln Met Lys Val Lys Xaa Asn Ala Ser Gln Val 
    530                 535                 540                 


Pro Ala Glu Pro Lys Glu Arg Pro Leu Leu Ser Leu Ile Arg Glu Lys 
545                 550                 555                 560 


Ala Arg Pro Arg Pro Xaa Gln Lys Ile Pro Glu Xaa Lys Ala Leu Lys 
                565                 570                 575     


His Lys Leu Ser Xaa Xaa Ser Glu Xaa Val Ser Gln Arg Xaa Ile Gly 
            580                 585                 590         


Lys Lys Gln Pro Lys Lys Val Glu Lys Asn Xaa Ser Xaa Asp Glu Phe 
        595                 600                 605             


Xaa Trp Pro Lys Pro Asn Ile Xaa Ser Ser Xaa Pro Lys Glu Lys Glu 
    610                 615                 620                 


Ser Val Glu Leu His Asp Pro Pro Arg Gly Arg Asn Lys Ala Xaa Ala 
625                 630                 635                 640 


His Lys Pro Ala Pro Arg Lys Glu Pro Arg Pro Asn Ile Pro Leu Ala 
                645                 650                 655     


Pro Glu Lys Lys Lys Tyr Arg Gly Pro Gly Lys Ile Val Pro Lys Ser 
            660                 665                 670         


Arg Glu Phe Ile Glu Xaa Asp Ser Ser Xaa Ser Asp Ser Asn Xaa Asp 
        675                 680                 685             


Gln Glu Glu Xaa Leu Gln Ile Lys Val Leu Pro Pro Cys Ile Ile Ser 
    690                 695                 700                 


Gly Gly Asn Xaa Ala Lys Ser Lys Glu Ile Cys Gly Ala Ser Leu Xaa 
705                 710                 715                 720 


Leu Ser Xaa Leu Met Ser Ser Ser Gly Ser Asn Asn Asn Leu Ser Ile 
                725                 730                 735     


Ser Asn Glu Glu Pro Xaa Phe Ser Pro Ile Pro Val Met Gln Xaa Glu 
            740                 745                 750         


Ile Leu Ser Pro Leu Arg Asp His Glu Asn Leu Lys Asn Leu Trp Val 
        755                 760                 765             


Lys Ile Asp Leu Asp Leu Leu Ser Arg Val Pro Gly His Ser Ser Leu 
    770                 775                 780                 


His Ala Ala Pro Ala Lys Pro Asp His Lys Glu Xaa Ala Xaa Lys Pro 
785                 790                 795                 800 


Lys Arg Gln Xaa Ala Val Xaa Ala Val Glu Lys Pro Ala Pro Lys Gly 
                805                 810                 815     


Lys Arg Lys His Lys Pro Ile Glu Val Ala Glu Lys Ile Pro Glu Lys 
            820                 825                 830         


Lys Gln Arg Leu Glu Glu Ala Xaa Xaa Ile Cys Leu Leu Pro Pro Cys 
        835                 840                 845             


Ile Ser Pro Ala Pro Pro His Lys Pro Pro Asn Xaa Arg Glu Asn Asn 
    850                 855                 860                 


Ser Ser Arg Arg Ala Asn Arg Arg Lys Glu Glu Lys Leu Phe Pro Pro 
865                 870                 875                 880 


Pro Leu Ser Pro Leu Pro Glu Asp Pro Pro Arg Arg Arg Asn Val Ser 
                885                 890                 895     


Gly Asn Asn Gly Pro Phe Gly Gln Asp Lys Asn Ile Ala Met Xaa Gly 
            900                 905                 910         


Gln Ile Xaa Ser Xaa Lys Pro Lys Arg Xaa Glu Gly Lys Phe Cys Ala 
        915                 920                 925             


Xaa Phe Lys Gly Ile Ser Val Asn Glu Gly Asp Xaa Pro Lys Lys Ala 
    930                 935                 940                 


Ser Ser Ala Xaa Ile Xaa Val Xaa Asn Xaa Ala Ile Ala Xaa Ala Xaa 
945                 950                 955                 960 


Val Xaa Ala Xaa Ala Ile Val Xaa Xaa Xaa Val Xaa Ala Xaa Ala Xaa 
                965                 970                 975     


Ala Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Ser Xaa Ile Xaa 
            980                 985                 990         


Ser Xaa Ile Xaa Xaa Gly Leu Met  Asp Ser Ser His Leu  Glu Met Xaa 
        995                 1000                 1005             


Ser Trp  Ala Ala Leu Pro Leu  Leu Ser Ser Ser Ser  Xaa Asn Val 
    1010                 1015                 1020             


Arg Arg  Pro Lys Leu Xaa Phe  Asp Asp Ser Val His  Asn Ala Asp 
    1025                 1030                 1035             


Tyr Tyr  Met Gln Glu Ala Lys  Lys Leu Lys His Lys  Ala Asp Ala 
    1040                 1045                 1050             


Leu Phe  Glu Lys Phe Gly Lys  Ala Val Asn Tyr Ala  Asp Ala Ala 
    1055                 1060                 1065             


Leu Ser  Phe Xaa Glu Cys Gly  Asn Ala Met Glu Arg  Asp Pro Leu 
    1070                 1075                 1080             


Glu Ala  Lys Ser Pro Tyr Xaa  Met Tyr Ser Glu Xaa  Val Glu Leu 
    1085                 1090                 1095             


Leu Arg  Tyr Ala Met Arg Leu  Lys Asn Phe Ala Ser  Pro Leu Ala 
    1100                 1105                 1110             


Ser Asp  Gly Asp Lys Lys Leu  Ala Val Leu Cys Tyr  Arg Cys Leu 
    1115                 1120                 1125             


Ser Leu  Leu Tyr Leu Arg Met  Phe Lys Leu Lys Lys  Asp His Ala 
    1130                 1135                 1140             


Met Lys  Tyr Ser Arg Ser Leu  Met Glu Tyr Phe Lys  Gln Asn Ala 
    1145                 1150                 1155             


Ser Lys  Val Ala Gln Ile Pro  Ser Pro Trp Val Ser  Asn Gly Lys 
    1160                 1165                 1170             


Asn Xaa  Pro Ser Pro Val Ser  Leu Asn Asn Val Ser  Pro Ile Asn 
    1175                 1180                 1185             


Ala Met  Gly Asn Cys Asn Asn  Gly Pro Val Xaa Ile  Pro Gln Arg 
    1190                 1195                 1200             


Ile His  His Met Ala Ala Ser  His Val Asn Ile Xaa  Ser Asn Val 
    1205                 1210                 1215             


Leu Arg  Gly Tyr Glu His Trp  Asp Met Ala Asp Lys  Leu Xaa Arg 
    1220                 1225                 1230             


Glu Asn  Lys Glu Phe Phe Gly  Asp Leu Asp Xaa Leu  Met Gly Pro 
    1235                 1240                 1245             


Leu Xaa  Gln His Ser Ser Met  Xaa Asn Leu Val Arg  Tyr Val Arg 
    1250                 1255                 1260             


Gln Gly  Leu Cys Trp Leu Arg  Ile Asp Ala His Leu  Leu 
    1265                 1270                 1275     


<210> 1903
<211> 1311
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (983)..(983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1007)..(1007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1107)..(1107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1234)..(1234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1267)..(1267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1291)..(1291)
<223> Selenocysteine

<400> 1903
Met Asp Leu Phe Asp Phe Phe Arg Asp Trp Asp Leu Glu Gln Gln Cys 
1               5                   10                  15      


His Tyr Glu Gln Asp Arg Ser Ala Leu Lys Lys Arg Glu Trp Glu Arg 
            20                  25                  30          


Arg Asn Gln Glu Val Gln Gln Glu Asp Asp Leu Phe Ser Ser Gly Phe 
        35                  40                  45              


Asp Leu Phe Gly Glu Pro Tyr Lys Val Ala Glu Tyr Xaa Asn Lys Gly 
    50                  55                  60                  


Asp Ala Leu Ala Asn Arg Val Gln Asn Xaa Leu Gly Asn Tyr Asp Glu 
65                  70                  75                  80  


Met Lys Asn Leu Leu Xaa Asn His Ser Asn Gln Asn His Leu Val Gly 
                85                  90                  95      


Ile Pro Lys Asn Ser Val Pro Gln Asn Pro Asn Asn Lys Asn Glu Pro 
            100                 105                 110         


Ser Phe Phe Pro Glu Gln Lys Asn Arg Ile Ile Pro Pro His Gln Asp 
        115                 120                 125             


Asn Xaa His Pro Ser Ala Pro Met Pro Pro Pro Ser Val Val Ile Leu 
    130                 135                 140                 


Asn Ser Xaa Leu Ile His Ser Asn Arg Lys Ser Lys Pro Glu Trp Ser 
145                 150                 155                 160 


Arg Asp Ser His Asn Pro Ser Xaa Val Leu Ala Ser Gln Ala Ser Gly 
                165                 170                 175     


Gln Pro Asn Lys Met Gln Xaa Leu Xaa Gln Asp Gln Ser Gln Ala Lys 
            180                 185                 190         


Leu Glu Asp Phe Phe Val Tyr Pro Ala Glu Gln Pro Gln Ile Gly Glu 
        195                 200                 205             


Val Glu Glu Ser Asn Pro Ser Ala Lys Glu Asp Ser Asn Pro Asn Ser 
    210                 215                 220                 


Ser Gly Glu Asp Ala Phe Lys Glu Ile Phe Gln Ser Asn Ser Pro Glu 
225                 230                 235                 240 


Glu Ser Glu Phe Ala Val Gln Ala Pro Gly Ser Pro Leu Val Ala Ser 
                245                 250                 255     


Ser Leu Leu Ala Pro Ser Ser Gly Leu Ser Val Gln Asn Phe Pro Pro 
            260                 265                 270         


Gly Leu Tyr Cys Lys Xaa Ser Met Gly Gln Gln Lys Pro Xaa Ala Tyr 
        275                 280                 285             


Val Arg Pro Met Asp Gly Gln Asp Gln Ala Pro Asp Ile Ser Pro Xaa 
    290                 295                 300                 


Leu Lys Pro Ser Ile Glu Phe Glu Asn Ser Phe Gly Asn Leu Ser Phe 
305                 310                 315                 320 


Gly Xaa Leu Leu Asp Gly Lys Pro Ser Ala Ala Ser Ser Lys Xaa Lys 
                325                 330                 335     


Leu Pro Lys Phe Xaa Ile Leu Gln Xaa Ser Glu Val Ser Leu Pro Ser 
            340                 345                 350         


Asp Pro Ser Cys Val Glu Glu Ile Leu Arg Glu Met Xaa His Ser Trp 
        355                 360                 365             


Pro Xaa Pro Leu Xaa Ser Met His Xaa Ala Gly His Ser Glu Gln Ser 
    370                 375                 380                 


Xaa Phe Ser Ile Pro Gly Gln Glu Ser Gln His Leu Xaa Pro Gly Phe 
385                 390                 395                 400 


Xaa Leu Gln Lys Trp Asn Asp Pro Xaa Xaa Arg Ala Ser Xaa Lys Ser 
                405                 410                 415     


Val Ser Phe Lys Ser Met Leu Glu Asp Asp Leu Lys Leu Ser Ser Asp 
            420                 425                 430         


Glu Asp Asp Leu Glu Pro Val Lys Xaa Leu Xaa Xaa Gln Cys Xaa Ala 
        435                 440                 445             


Xaa Glu Leu Tyr Gln Ala Val Glu Lys Ala Lys Pro Arg Asn Asn Pro 
    450                 455                 460                 


Val Asn Pro Pro Leu Ala Xaa Pro Gln Pro Pro Pro Ala Val Gln Ala 
465                 470                 475                 480 


Ser Gly Gly Ser Gly Ser Ser Ser Glu Ser Glu Ser Ser Ser Glu Ser 
                485                 490                 495     


Asp Ser Asp Xaa Glu Ser Ser Xaa Xaa Asp Ser Glu Ser Asn Glu Ala 
            500                 505                 510         


Pro Arg Val Ala Xaa Pro Glu Pro Glu Pro Pro Ser Xaa Asn Lys Trp 
        515                 520                 525             


Gln Leu Asp Lys Trp Leu Asn Lys Val Xaa Ser Gln Asn Lys Ser Phe 
    530                 535                 540                 


Ile Cys Gly Gln Asn Glu Xaa Pro Met Glu Xaa Ile Ser Leu Pro Pro 
545                 550                 555                 560 


Pro Ile Ile Gln Pro Met Glu Val Gln Met Lys Val Lys Xaa Asn Ala 
                565                 570                 575     


Ser Gln Val Pro Ala Glu Pro Lys Glu Arg Pro Leu Leu Ser Leu Ile 
            580                 585                 590         


Arg Glu Lys Ala Arg Pro Arg Pro Xaa Gln Lys Ile Pro Glu Xaa Lys 
        595                 600                 605             


Ala Leu Lys His Lys Leu Ser Xaa Xaa Ser Glu Xaa Val Ser Gln Arg 
    610                 615                 620                 


Xaa Ile Gly Lys Lys Gln Pro Lys Lys Val Glu Lys Asn Xaa Ser Xaa 
625                 630                 635                 640 


Asp Glu Phe Xaa Trp Pro Lys Pro Asn Ile Xaa Ser Ser Xaa Pro Lys 
                645                 650                 655     


Glu Lys Glu Ser Val Glu Leu His Asp Pro Pro Arg Gly Arg Asn Lys 
            660                 665                 670         


Ala Xaa Ala His Lys Pro Ala Pro Arg Lys Glu Pro Arg Pro Asn Ile 
        675                 680                 685             


Pro Leu Ala Pro Glu Lys Lys Lys Tyr Arg Gly Pro Gly Lys Ile Val 
    690                 695                 700                 


Pro Lys Ser Arg Glu Phe Ile Glu Xaa Asp Ser Ser Xaa Ser Asp Ser 
705                 710                 715                 720 


Asn Xaa Asp Gln Glu Glu Xaa Leu Gln Ile Lys Val Leu Pro Pro Cys 
                725                 730                 735     


Ile Ile Ser Gly Gly Asn Xaa Ala Lys Ser Lys Glu Ile Cys Gly Ala 
            740                 745                 750         


Ser Leu Xaa Leu Ser Xaa Leu Met Ser Ser Ser Gly Ser Asn Asn Asn 
        755                 760                 765             


Leu Ser Ile Ser Asn Glu Glu Pro Xaa Phe Ser Pro Ile Pro Val Met 
    770                 775                 780                 


Gln Xaa Glu Ile Leu Ser Pro Leu Arg Asp His Glu Asn Leu Lys Asn 
785                 790                 795                 800 


Leu Trp Val Lys Ile Asp Leu Asp Leu Leu Ser Arg Val Pro Gly His 
                805                 810                 815     


Ser Ser Leu His Ala Ala Pro Ala Lys Pro Asp His Lys Glu Xaa Ala 
            820                 825                 830         


Xaa Lys Pro Lys Arg Gln Xaa Ala Val Xaa Ala Val Glu Lys Pro Ala 
        835                 840                 845             


Pro Lys Gly Lys Arg Lys His Lys Pro Ile Glu Val Ala Glu Lys Ile 
    850                 855                 860                 


Pro Glu Lys Lys Gln Arg Leu Glu Glu Ala Xaa Xaa Ile Cys Leu Leu 
865                 870                 875                 880 


Pro Pro Cys Ile Ser Pro Ala Pro Pro His Lys Pro Pro Asn Xaa Arg 
                885                 890                 895     


Glu Asn Asn Ser Ser Arg Arg Ala Asn Arg Arg Lys Glu Glu Lys Leu 
            900                 905                 910         


Phe Pro Pro Pro Leu Ser Pro Leu Pro Glu Asp Pro Pro Arg Arg Arg 
        915                 920                 925             


Asn Val Ser Gly Asn Asn Gly Pro Phe Gly Gln Asp Lys Asn Ile Ala 
    930                 935                 940                 


Met Xaa Gly Gln Ile Xaa Ser Xaa Lys Pro Lys Arg Xaa Glu Gly Lys 
945                 950                 955                 960 


Phe Cys Ala Xaa Phe Lys Gly Ile Ser Val Asn Glu Gly Asp Xaa Pro 
                965                 970                 975     


Lys Lys Ala Ser Ser Ala Xaa Ile Xaa Val Xaa Asn Xaa Ala Ile Ala 
            980                 985                 990         


Xaa Ala Xaa Val Xaa Ala Xaa Ala  Ile Val Xaa Xaa Xaa  Val Xaa Ala 
        995                 1000                 1005             


Xaa Ala  Xaa Ala Xaa Ala Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Ile 
    1010                 1015                 1020             


Ser Xaa  Ile Xaa Ser Xaa Ile  Xaa Xaa Gly Leu Met  Asp Ser Ser 
    1025                 1030                 1035             


His Leu  Glu Met Xaa Ser Trp  Ala Ala Leu Pro Leu  Leu Ser Ser 
    1040                 1045                 1050             


Ser Ser  Xaa Asn Val Arg Arg  Pro Lys Leu Xaa Phe  Asp Asp Ser 
    1055                 1060                 1065             


Val His  Asn Ala Asp Tyr Tyr  Met Gln Glu Ala Lys  Lys Leu Lys 
    1070                 1075                 1080             


His Lys  Ala Asp Ala Leu Phe  Glu Lys Phe Gly Lys  Ala Val Asn 
    1085                 1090                 1095             


Tyr Ala  Asp Ala Ala Leu Ser  Phe Xaa Glu Cys Gly  Asn Ala Met 
    1100                 1105                 1110             


Glu Arg  Asp Pro Leu Glu Ala  Lys Ser Pro Tyr Xaa  Met Tyr Ser 
    1115                 1120                 1125             


Glu Xaa  Val Glu Leu Leu Arg  Tyr Ala Met Arg Leu  Lys Asn Phe 
    1130                 1135                 1140             


Ala Ser  Pro Leu Ala Ser Asp  Gly Asp Lys Lys Leu  Ala Val Leu 
    1145                 1150                 1155             


Cys Tyr  Arg Cys Leu Ser Leu  Leu Tyr Leu Arg Met  Phe Lys Leu 
    1160                 1165                 1170             


Lys Lys  Asp His Ala Met Lys  Tyr Ser Arg Ser Leu  Met Glu Tyr 
    1175                 1180                 1185             


Phe Lys  Gln Asn Ala Ser Lys  Val Ala Gln Ile Pro  Ser Pro Trp 
    1190                 1195                 1200             


Val Ser  Asn Gly Lys Asn Xaa  Pro Ser Pro Val Ser  Leu Asn Asn 
    1205                 1210                 1215             


Val Ser  Pro Ile Asn Ala Met  Gly Asn Cys Asn Asn  Gly Pro Val 
    1220                 1225                 1230             


Xaa Ile  Pro Gln Arg Ile His  His Met Ala Ala Ser  His Val Asn 
    1235                 1240                 1245             


Ile Xaa  Ser Asn Val Leu Arg  Gly Tyr Glu His Trp  Asp Met Ala 
    1250                 1255                 1260             


Asp Lys  Leu Xaa Arg Glu Asn  Lys Glu Phe Phe Gly  Asp Leu Asp 
    1265                 1270                 1275             


Xaa Leu  Met Gly Pro Leu Xaa  Gln His Ser Ser Met  Xaa Asn Leu 
    1280                 1285                 1290             


Val Arg  Tyr Val Arg Gln Gly  Leu Cys Trp Leu Arg  Ile Asp Ala 
    1295                 1300                 1305             


His Leu  Leu 
    1310     


<210> 1904
<211> 952
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<400> 1904
Met Lys Phe Lys Arg Arg His Gln Ala Phe Pro Ser Phe Phe Lys Met 
1               5                   10                  15      


Lys Val Ser Leu Pro Ser Asp Pro Ser Cys Val Glu Glu Ile Leu Arg 
            20                  25                  30          


Glu Ser Gln His Leu Xaa Pro Gly Phe Xaa Leu Gln Lys Trp Asn Asp 
        35                  40                  45              


Pro Xaa Xaa Arg Ala Ser Xaa Lys Ser Val Ser Phe Lys Ser Met Leu 
    50                  55                  60                  


Glu Asp Asp Leu Lys Leu Ser Ser Asp Glu Asp Asp Leu Glu Pro Val 
65                  70                  75                  80  


Lys Xaa Leu Xaa Xaa Gln Cys Xaa Ala Xaa Glu Leu Tyr Gln Ala Val 
                85                  90                  95      


Glu Lys Ala Lys Pro Arg Asn Asn Pro Val Asn Pro Pro Leu Ala Xaa 
            100                 105                 110         


Pro Gln Pro Pro Pro Ala Val Gln Ala Ser Gly Gly Ser Gly Ser Ser 
        115                 120                 125             


Ser Glu Ser Glu Ser Ser Ser Glu Ser Asp Ser Asp Xaa Glu Ser Ser 
    130                 135                 140                 


Xaa Xaa Asp Ser Glu Ser Asn Glu Ala Pro Arg Val Ala Xaa Pro Glu 
145                 150                 155                 160 


Pro Glu Pro Pro Ser Xaa Asn Lys Trp Gln Leu Asp Lys Trp Leu Asn 
                165                 170                 175     


Lys Val Xaa Ser Gln Asn Lys Ser Phe Ile Cys Gly Gln Asn Glu Xaa 
            180                 185                 190         


Pro Met Glu Xaa Ile Ser Leu Pro Pro Pro Ile Ile Gln Pro Met Glu 
        195                 200                 205             


Val Gln Met Lys Val Lys Xaa Asn Ala Ser Gln Val Pro Ala Glu Pro 
    210                 215                 220                 


Lys Glu Arg Pro Leu Leu Ser Leu Ile Arg Glu Lys Ala Arg Pro Arg 
225                 230                 235                 240 


Pro Xaa Gln Lys Ile Pro Glu Xaa Lys Ala Leu Lys His Lys Leu Ser 
                245                 250                 255     


Xaa Xaa Ser Glu Xaa Val Ser Gln Arg Xaa Ile Gly Lys Lys Gln Pro 
            260                 265                 270         


Lys Lys Val Glu Lys Asn Xaa Ser Xaa Asp Glu Phe Xaa Trp Pro Lys 
        275                 280                 285             


Pro Asn Ile Xaa Ser Ser Xaa Pro Lys Glu Lys Glu Ser Val Glu Leu 
    290                 295                 300                 


His Asp Pro Pro Arg Gly Arg Asn Lys Ala Xaa Ala His Lys Pro Ala 
305                 310                 315                 320 


Pro Arg Lys Glu Pro Arg Pro Asn Ile Pro Leu Ala Pro Glu Lys Lys 
                325                 330                 335     


Lys Tyr Arg Gly Pro Gly Lys Ile Val Pro Lys Ser Arg Glu Phe Ile 
            340                 345                 350         


Glu Xaa Asp Ser Ser Xaa Ser Asp Ser Asn Xaa Asp Gln Glu Glu Xaa 
        355                 360                 365             


Leu Gln Ile Lys Val Leu Pro Pro Cys Ile Ile Ser Gly Gly Asn Xaa 
    370                 375                 380                 


Ala Lys Ser Lys Glu Ile Cys Gly Ala Ser Leu Xaa Leu Ser Xaa Leu 
385                 390                 395                 400 


Met Ser Ser Ser Gly Ser Asn Asn Asn Leu Ser Ile Ser Asn Glu Glu 
                405                 410                 415     


Pro Xaa Phe Ser Pro Ile Pro Val Met Gln Xaa Glu Ile Leu Ser Pro 
            420                 425                 430         


Leu Arg Asp His Glu Asn Leu Lys Asn Leu Trp Val Lys Ile Asp Leu 
        435                 440                 445             


Asp Leu Leu Ser Arg Val Pro Gly His Ser Ser Leu His Ala Ala Pro 
    450                 455                 460                 


Ala Lys Pro Asp His Lys Glu Xaa Ala Xaa Lys Pro Lys Arg Gln Xaa 
465                 470                 475                 480 


Ala Val Xaa Ala Val Glu Lys Pro Ala Pro Lys Gly Lys Arg Lys His 
                485                 490                 495     


Lys Pro Ile Glu Val Ala Glu Lys Ile Pro Glu Lys Lys Gln Arg Leu 
            500                 505                 510         


Glu Glu Ala Xaa Xaa Ile Cys Leu Leu Pro Pro Cys Ile Ser Pro Ala 
        515                 520                 525             


Pro Pro His Lys Pro Pro Asn Xaa Arg Glu Asn Asn Ser Ser Arg Arg 
    530                 535                 540                 


Ala Asn Arg Arg Lys Glu Glu Lys Leu Phe Pro Pro Pro Leu Ser Pro 
545                 550                 555                 560 


Leu Pro Glu Asp Pro Pro Arg Arg Arg Asn Val Ser Gly Asn Asn Gly 
                565                 570                 575     


Pro Phe Gly Gln Asp Lys Asn Ile Ala Met Xaa Gly Gln Ile Xaa Ser 
            580                 585                 590         


Xaa Lys Pro Lys Arg Xaa Glu Gly Lys Phe Cys Ala Xaa Phe Lys Gly 
        595                 600                 605             


Ile Ser Val Asn Glu Gly Asp Xaa Pro Lys Lys Ala Ser Ser Ala Xaa 
    610                 615                 620                 


Ile Xaa Val Xaa Asn Xaa Ala Ile Ala Xaa Ala Xaa Val Xaa Ala Xaa 
625                 630                 635                 640 


Ala Ile Val Xaa Xaa Xaa Val Xaa Ala Xaa Ala Xaa Ala Xaa Ala Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Ser Xaa Ile Xaa Ser Xaa Ile Xaa 
            660                 665                 670         


Xaa Gly Leu Met Asp Ser Ser His Leu Glu Met Xaa Ser Trp Ala Ala 
        675                 680                 685             


Leu Pro Leu Leu Ser Ser Ser Ser Xaa Asn Val Arg Arg Pro Lys Leu 
    690                 695                 700                 


Xaa Phe Asp Asp Ser Val His Asn Ala Asp Tyr Tyr Met Gln Glu Ala 
705                 710                 715                 720 


Lys Lys Leu Lys His Lys Ala Asp Ala Leu Phe Glu Lys Phe Gly Lys 
                725                 730                 735     


Ala Val Asn Tyr Ala Asp Ala Ala Leu Ser Phe Xaa Glu Cys Gly Asn 
            740                 745                 750         


Ala Met Glu Arg Asp Pro Leu Glu Ala Lys Ser Pro Tyr Xaa Met Tyr 
        755                 760                 765             


Ser Glu Xaa Val Glu Leu Leu Arg Tyr Ala Met Arg Leu Lys Asn Phe 
    770                 775                 780                 


Ala Ser Pro Leu Ala Ser Asp Gly Asp Lys Lys Leu Ala Val Leu Cys 
785                 790                 795                 800 


Tyr Arg Cys Leu Ser Leu Leu Tyr Leu Arg Met Phe Lys Leu Lys Lys 
                805                 810                 815     


Asp His Ala Met Lys Tyr Ser Arg Ser Leu Met Glu Tyr Phe Lys Gln 
            820                 825                 830         


Asn Ala Ser Lys Val Ala Gln Ile Pro Ser Pro Trp Val Ser Asn Gly 
        835                 840                 845             


Lys Asn Xaa Pro Ser Pro Val Ser Leu Asn Asn Val Ser Pro Ile Asn 
    850                 855                 860                 


Ala Met Gly Asn Cys Asn Asn Gly Pro Val Xaa Ile Pro Gln Arg Ile 
865                 870                 875                 880 


His His Met Ala Ala Ser His Val Asn Ile Xaa Ser Asn Val Leu Arg 
                885                 890                 895     


Gly Tyr Glu His Trp Asp Met Ala Asp Lys Leu Xaa Arg Glu Asn Lys 
            900                 905                 910         


Glu Phe Phe Gly Asp Leu Asp Xaa Leu Met Gly Pro Leu Xaa Gln His 
        915                 920                 925             


Ser Ser Met Xaa Asn Leu Val Arg Tyr Val Arg Gln Gly Leu Cys Trp 
    930                 935                 940                 


Leu Arg Ile Asp Ala His Leu Leu 
945                 950         


<210> 1905
<211> 185
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<400> 1905
Gly His Arg Asp Cys Lys Arg Gln Lys Leu Val Phe Asp Asp Met Pro 
1               5                   10                  15      


Arg Ser Ala Asp Tyr Phe Met Gln Glu Ala Lys Arg Met Lys His Lys 
            20                  25                  30          


Ala Asp Ala Met Val Glu Lys Phe Gly Lys Ala Leu Asn Tyr Ala Glu 
        35                  40                  45              


Ala Ala Leu Ser Phe Ile Glu Cys Gly Asn Ala Met Glu Gln Gly Pro 
    50                  55                  60                  


Met Glu Ser Lys Ser Pro Tyr Xaa Met Tyr Ser Glu Xaa Val Glu Leu 
65                  70                  75                  80  


Ile Arg Tyr Ala Met Arg Leu Lys Xaa His Ser Gly Pro Asn Ala Xaa 
                85                  90                  95      


Pro Glu Asp Lys Gln Leu Ala Ala Leu Cys Tyr Arg Cys Leu Ala Leu 
            100                 105                 110         


Leu Tyr Trp Arg Met Phe Arg Leu Lys Arg Asp His Ala Val Lys Tyr 
        115                 120                 125             


Ser Lys Ala Leu Ile Asp Tyr Phe Lys Asn Ser Ser Lys Ala Ala Gln 
    130                 135                 140                 


Ala Pro Ser Pro Trp Gly Ala Ser Gly Asn Ser Val Gly Ser Gln Gly 
145                 150                 155                 160 


Ser Leu Ser Asn Ala Ser Ala Leu Ser Pro Ser Xaa Ile Val Ser Ile 
                165                 170                 175     


Pro Gln Arg Ile His Gln Met Ala Ala 
            180                 185 


<210> 1906
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1906
Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu 
    


<210> 1907
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<400> 1907
Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Cys Val Tyr Glu Pro Asp Arg Asn Ala Leu Arg Arg Lys Glu Arg 
            20                  25                  30          


Glu Arg Arg Asn Gln Glu Xaa Gln Gln Asp Asp Gly Xaa Phe Asn Ser 
        35                  40                  45              


Ser Tyr Ser Leu Phe Ser Glu Pro Tyr Lys Xaa Asn Lys Gly Asp Glu 
    50                  55                  60                  


Leu Ser Asn Arg Ile Gln Asn Xaa Leu Gly Asn Tyr Asp Glu Met Lys 
65                  70                  75                  80  


Asp Phe Leu Xaa Asp Arg Ser Asn Gln Ser His Leu Val Gly Val Pro 
                85                  90                  95      


Lys Pro Gly 
            


<210> 1908
<211> 114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 1908
Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Cys Val Tyr Glu Pro Asp Arg Asn Ala Leu Arg Arg Lys Glu Arg 
            20                  25                  30          


Glu Arg Arg Asn Gln Glu Xaa Gln Gln Asp Asp Gly Xaa Phe Asn Ser 
        35                  40                  45              


Ser Tyr Ser Leu Phe Ser Glu Pro Tyr Lys Xaa Asn Lys Gly Asp Glu 
    50                  55                  60                  


Leu Ser Asn Arg Ile Gln Asn Xaa Leu Gly Asn Tyr Asp Glu Met Lys 
65                  70                  75                  80  


Asp Phe Leu Xaa Asp Arg Ser Asn Gln Ser His Leu Val Gly Val Pro 
                85                  90                  95      


Lys Pro Gly Val Pro Gln Xaa Pro Val Asn Lys Ile Asp Glu His Phe 
            100                 105                 110         


Val Ala 
        


<210> 1909
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(129)
<223> Selenocysteine

<400> 1909
Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Cys Val Tyr Glu Pro Asp Arg Asn Ala Leu Arg Arg Lys Glu Arg 
            20                  25                  30          


Glu Arg Arg Asn Gln Glu Xaa Gln Gln Asp Asp Gly Xaa Phe Asn Ser 
        35                  40                  45              


Ser Tyr Ser Leu Phe Ser Glu Pro Tyr Lys Xaa Asn Lys Gly Asp Glu 
    50                  55                  60                  


Leu Ser Asn Arg Ile Gln Asn Xaa Leu Gly Asn Tyr Asp Glu Met Lys 
65                  70                  75                  80  


Asp Phe Leu Xaa Asp Arg Ser Asn Gln Ser His Leu Val Gly Val Pro 
                85                  90                  95      


Lys Pro Gly Val Pro Gln Xaa Pro Val Asn Lys Ile Asp Glu His Phe 
            100                 105                 110         


Val Ala Asp Ser Arg Ala Gln Asn Gln Pro Ser Ser Ile Cys Ser Xaa 
        115                 120                 125             


Xaa 
    


<210> 1910
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<400> 1910
Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Cys Val Tyr Glu Pro Asp Arg Asn Ala Leu Arg Arg Lys Glu Arg 
            20                  25                  30          


Glu Arg Arg Asn Gln Glu Xaa Gln Gln Asp Asp Gly Xaa Phe Asn Ser 
        35                  40                  45              


Ser Tyr Ser Leu Phe Ser Glu Pro Tyr Lys Xaa Asn Lys Gly Asp Glu 
    50                  55                  60                  


Leu Ser Asn Arg Ile Gln Asn Xaa Leu Gly Asn Tyr Asp Glu Met Lys 
65                  70                  75                  80  


Asp Phe Leu Xaa Asp Arg Ser Asn Gln Ser His Leu Val Gly Val Pro 
                85                  90                  95      


Lys Pro Gly Val Pro Gln Xaa Pro Val Asn Lys Ile Asp Glu His Phe 
            100                 105                 110         


Val Ala Asp Ser Arg Ala Gln Asn Gln Pro Ser Ser Ile Cys Ser Xaa 
        115                 120                 125             


Xaa Xaa Ser Xaa Pro Ala Ala Val Pro Val Gln Gln Ser Lys Arg Gly 
    130                 135                 140                 


Xaa Met Gly Trp Gln Lys Ala Gly His Pro Pro 
145                 150                 155 


<210> 1911
<211> 161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<400> 1911
Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Cys Val Tyr Glu Pro Asp Arg Asn Ala Leu Arg Arg Lys Glu Arg 
            20                  25                  30          


Glu Arg Arg Asn Gln Glu Xaa Gln Gln Asp Asp Gly Xaa Phe Asn Ser 
        35                  40                  45              


Ser Tyr Ser Leu Phe Ser Glu Pro Tyr Lys Xaa Asn Lys Gly Asp Glu 
    50                  55                  60                  


Leu Ser Asn Arg Ile Gln Asn Xaa Leu Gly Asn Tyr Asp Glu Met Lys 
65                  70                  75                  80  


Asp Phe Leu Xaa Asp Arg Ser Asn Gln Ser His Leu Val Gly Val Pro 
                85                  90                  95      


Lys Pro Gly Val Pro Gln Xaa Pro Val Asn Lys Ile Asp Glu His Phe 
            100                 105                 110         


Val Ala Asp Ser Arg Ala Gln Asn Gln Pro Ser Ser Ile Cys Ser Xaa 
        115                 120                 125             


Xaa Xaa Ser Xaa Pro Ala Ala Val Pro Val Gln Gln Ser Lys Arg Gly 
    130                 135                 140                 


Xaa Met Gly Trp Gln Lys Ala Gly His Pro Pro Ser Asp Gly Gln Gln 
145                 150                 155                 160 


Arg 
    


<210> 1912
<211> 1226
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1200)..(1200)
<223> Selenocysteine

<400> 1912
Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Cys Val Tyr Glu Pro Asp Arg Asn Ala Leu Arg Arg Lys Glu Arg 
            20                  25                  30          


Glu Arg Arg Asn Gln Glu Xaa Gln Gln Asp Asp Gly Xaa Phe Asn Ser 
        35                  40                  45              


Ser Tyr Ser Leu Phe Ser Glu Pro Tyr Lys Xaa Asn Lys Gly Asp Glu 
    50                  55                  60                  


Leu Ser Asn Arg Ile Gln Asn Xaa Leu Gly Asn Tyr Asp Glu Met Lys 
65                  70                  75                  80  


Asp Phe Leu Xaa Asp Arg Ser Asn Gln Ser His Leu Val Gly Val Pro 
                85                  90                  95      


Lys Pro Gly Val Pro Gln Xaa Pro Val Asn Lys Ile Asp Glu His Phe 
            100                 105                 110         


Val Ala Asp Ser Arg Ala Gln Asn Gln Pro Ser Ser Ile Cys Ser Xaa 
        115                 120                 125             


Xaa Xaa Ser Xaa Pro Ala Ala Val Pro Val Gln Gln Ser Lys Arg Gly 
    130                 135                 140                 


Xaa Met Gly Trp Gln Lys Ala Gly His Pro Pro Ser Asp Gly Gln Gln 
145                 150                 155                 160 


Arg Ala Xaa Gln Gln Gly Ser Leu Arg Xaa Leu Leu Gly Asp Gly Val 
                165                 170                 175     


Gly Arg Gln Gln Pro Arg Ala Lys Gln Val Cys Asn Val Glu Val Gly 
            180                 185                 190         


Leu Gln Xaa Gln Glu Arg Pro Pro Ala Met Ala Ala Lys His Ser Ser 
        195                 200                 205             


Ser Gly His Cys Val Gln Asn Phe Pro Pro Ser Leu Ala Ser Lys Pro 
    210                 215                 220                 


Ser Leu Val Gln Gln Lys Pro Xaa Ala Tyr Val Arg Pro Met Asp Gly 
225                 230                 235                 240 


Gln Asp Gln Ala Pro Asp Glu Ser Pro Lys Leu Lys Ser Ser Ser Glu 
                245                 250                 255     


Xaa Ser Val His Cys Xaa Ser Tyr Arg Gly Val Pro Ala Ser Lys Pro 
            260                 265                 270         


Glu Pro Ala Arg Ala Lys Ala Lys Leu Ser Lys Phe Ser Ile Pro Lys 
        275                 280                 285             


Gln Gly Glu Glu Ser Arg Ser Gly Glu Xaa Asn Ser Cys Val Glu Glu 
    290                 295                 300                 


Ile Ile Arg Glu Met Xaa Trp Leu Pro Pro Leu Ser Ala Ile Gln Ala 
305                 310                 315                 320 


Pro Gly Lys Val Glu Pro Xaa Lys Phe Pro Phe Pro Asn Lys Asp Ser 
                325                 330                 335     


Gln Leu Val Ser Ser Gly His Asn Asn Pro Lys Lys Gly Asp Ala Glu 
            340                 345                 350         


Pro Glu Ser Pro Asp Asn Gly Xaa Ser Asn Xaa Ser Met Leu Glu Asp 
        355                 360                 365             


Asp Leu Lys Leu Ser Ser Asp Glu Glu Glu Asn Glu Gln Gln Ala Ala 
    370                 375                 380                 


Gln Arg Xaa Ala Leu Arg Ala Leu Ser Asp Ser Ala Val Val Gln Gln 
385                 390                 395                 400 


Pro Asn Cys Arg Xaa Ser Val Pro Ser Ser Lys Gly Ser Ser Ser Ser 
                405                 410                 415     


Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Asp Ser Glu Ser Ser Ser 
            420                 425                 430         


Gly Ser Asp Ser Glu Xaa Glu Ser Ser Ser Ser Glu Ser Glu Gly Ser 
        435                 440                 445             


Lys Pro Pro His Phe Ser Ser Pro Glu Ala Glu Pro Ala Ser Ser Asn 
    450                 455                 460                 


Lys Trp Gln Leu Asp Lys Trp Leu Asn Lys Val Asn Pro His Lys Pro 
465                 470                 475                 480 


Pro Ile Leu Ile Gln Asn Glu Ser His Gly Ser Glu Ser Asn Gln Tyr 
                485                 490                 495     


Tyr Asn Pro Val Lys Glu Asp Val Gln Asp Cys Gly Lys Val Pro Asp 
            500                 505                 510         


Val Cys Gln Pro Ser Leu Arg Glu Lys Glu Ile Lys Ser Xaa Cys Lys 
        515                 520                 525             


Glu Glu Gln Arg Pro Arg Xaa Ala Asn Lys Ala Pro Gly Ser Lys Gly 
    530                 535                 540                 


Val Lys Gln Lys Ser Pro Pro Ala Ala Val Ala Val Ala Val Ser Ala 
545                 550                 555                 560 


Ala Ala Pro Pro Pro Ala Val Pro Cys Ala Pro Ala Glu Asn Ala Pro 
                565                 570                 575     


Ala Pro Ala Arg Arg Ser Ala Gly Lys Lys Pro Xaa Arg Arg Xaa Glu 
            580                 585                 590         


Arg Xaa Ser Ala Gly Asp Gly Ala Asn Cys His Arg Pro Glu Glu Pro 
        595                 600                 605             


Ala Ala Ala Asp Ala Leu Gly Xaa Ser Val Val Val Pro Pro Glu Pro 
    610                 615                 620                 


Xaa Lys Xaa Arg Pro Cys Gly Asn Asn Arg Ala Ser His Arg Lys Glu 
625                 630                 635                 640 


Leu Arg Ser Ser Val Xaa Cys Glu Lys Arg Arg Xaa Arg Gly Leu Ser 
                645                 650                 655     


Arg Ile Val Pro Lys Ser Lys Glu Phe Ile Glu Xaa Glu Ser Ser Ser 
            660                 665                 670         


Ser Ser Ser Ser Ser Asp Ser Asp Leu Glu Ser Glu Gln Glu Glu Tyr 
        675                 680                 685             


Pro Leu Ser Lys Ala Gln Xaa Val Ala Ala Ser Ala Ser Ser Gly Asn 
    690                 695                 700                 


Asp Gln Arg Leu Lys Glu Ala Ala Ala Asn Gly Gly Ser Gly Pro Arg 
705                 710                 715                 720 


Ala Pro Val Gly Ser Ile Asn Ala Arg Xaa Xaa Ser Asp Ile Ala Lys 
                725                 730                 735     


Glu Leu Glu Glu Gln Phe Tyr Xaa Leu Val Pro Phe Gly Arg Asn Glu 
            740                 745                 750         


Leu Leu Ser Pro Leu Lys Asp Ser Asp Glu Ile Arg Ser Leu Trp Val 
        755                 760                 765             


Lys Ile Asp Leu Xaa Leu Leu Ser Arg Ile Pro Glu His Leu Pro Gln 
    770                 775                 780                 


Glu Pro Gly Val Leu Ser Ala Pro Ala Xaa Lys Asp Ser Glu Ser Ala 
785                 790                 795                 800 


Pro Pro Ser His Xaa Ser Asp Xaa Pro Ala Glu Lys Ala Leu Pro Lys 
                805                 810                 815     


Ser Lys Arg Lys Arg Lys Cys Asp Asn Glu Asp Asp Tyr Arg Glu Ile 
            820                 825                 830         


Lys Lys Ser Gln Gly Glu Lys Asp Ser Ser Ser Arg Leu Ala Xaa Ser 
        835                 840                 845             


Xaa Ser Asn Xaa Leu Ser Ala Asn His Cys Asn Met Asn Ile Asn Ser 
    850                 855                 860                 


Val Ala Ile Pro Ile Asn Lys Asn Glu Lys Met Leu Arg Ser Pro Ile 
865                 870                 875                 880 


Ser Pro Leu Ser Asp Ala Ser Lys His Lys Tyr Xaa Ser Glu Asp Leu 
                885                 890                 895     


Xaa Ser Ser Ser Arg Pro Asn Gly Asn Ser Leu Phe Xaa Ser Ala Ser 
            900                 905                 910         


Ser Ser Lys Lys Pro Lys Ala Asp Ser Gln Leu Gln Pro His Gly Gly 
        915                 920                 925             


Asp Leu Xaa Lys Ala Ala His Asn Asn Ser Glu Asn Ile Pro Leu His 
    930                 935                 940                 


Lys Ser Arg Pro Gln Xaa Lys Pro Trp Ser Pro Gly Ser Asn Gly His 
945                 950                 955                 960 


Arg Asp Cys Lys Arg Gln Lys Leu Val Phe Asp Asp Met Pro Arg Ser 
                965                 970                 975     


Ala Asp Tyr Phe Met Gln Glu Ala Lys Arg Met Lys His Lys Ala Asp 
            980                 985                 990         


Ala Met Val Glu Lys Phe Gly Lys  Ala Leu Asn Tyr Ala  Glu Ala Ala 
        995                 1000                 1005             


Leu Ser  Phe Ile Glu Cys Gly  Asn Ala Met Glu Gln  Gly Pro Met 
    1010                 1015                 1020             


Glu Ser  Lys Ser Pro Tyr Xaa  Met Tyr Ser Glu Xaa  Val Glu Leu 
    1025                 1030                 1035             


Ile Arg  Tyr Ala Met Arg Leu  Lys Xaa His Ser Gly  Pro Asn Ala 
    1040                 1045                 1050             


Xaa Pro  Glu Asp Lys Gln Leu  Ala Ala Leu Cys Tyr  Arg Cys Leu 
    1055                 1060                 1065             


Ala Leu  Leu Tyr Trp Arg Met  Phe Arg Leu Lys Arg  Asp His Ala 
    1070                 1075                 1080             


Val Lys  Tyr Ser Lys Ala Leu  Ile Asp Tyr Phe Lys  Asn Ser Ser 
    1085                 1090                 1095             


Lys Ala  Ala Gln Ala Pro Ser  Pro Trp Gly Ala Ser  Gly Lys Ser 
    1100                 1105                 1110             


Xaa Gly  Xaa Pro Ser Pro Met  Ser Pro Asn Pro Ser  Pro Ala Ser 
    1115                 1120                 1125             


Ser Val  Gly Ser Gln Gly Ser  Leu Ser Asn Ala Ser  Ala Leu Ser 
    1130                 1135                 1140             


Pro Ser  Xaa Ile Val Ser Ile  Pro Gln Arg Ile His  Gln Met Ala 
    1145                 1150                 1155             


Ala Asn  His Val Ser Ile Xaa  Asn Ser Ile Leu His  Ser Tyr Asp 
    1160                 1165                 1170             


Tyr Trp  Glu Met Ala Asp Asn  Leu Ala Lys Glu Asn  Arg Glu Phe 
    1175                 1180                 1185             


Phe Asn  Asp Leu Asp Leu Leu  Met Gly Pro Val Xaa  Leu His Ser 
    1190                 1195                 1200             


Ser Met  Glu His Leu Val Gln  Tyr Ser Gln Gln Gly  Leu His Trp 
    1205                 1210                 1215             


Leu Arg  Asn Ser Ala His Leu  Ser 
    1220                 1225     


<210> 1913
<211> 1251
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1190)..(1190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1225)
<223> Selenocysteine

<400> 1913
Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Trp Gly Glu Asp Ile Leu Asn Gln Arg Asn Asp Ser Leu Val Val 
            20                  25                  30          


Glu Phe Gln Ser Ser Ala Ser Arg Cys Arg Ser Val Tyr Glu Pro Asp 
        35                  40                  45              


Arg Asn Ala Leu Arg Arg Lys Glu Arg Glu Arg Arg Asn Gln Glu Xaa 
    50                  55                  60                  


Gln Gln Asp Asp Gly Xaa Phe Asn Ser Ser Tyr Ser Leu Phe Ser Glu 
65                  70                  75                  80  


Pro Tyr Lys Xaa Asn Lys Gly Asp Glu Leu Ser Asn Arg Ile Gln Asn 
                85                  90                  95      


Xaa Leu Gly Asn Tyr Asp Glu Met Lys Asp Phe Leu Xaa Asp Arg Ser 
            100                 105                 110         


Asn Gln Ser His Leu Val Gly Val Pro Lys Pro Gly Val Pro Gln Xaa 
        115                 120                 125             


Pro Val Asn Lys Ile Asp Glu His Phe Val Ala Asp Ser Arg Ala Gln 
    130                 135                 140                 


Asn Gln Pro Ser Ser Ile Cys Ser Xaa Xaa Xaa Ser Xaa Pro Ala Ala 
145                 150                 155                 160 


Val Pro Val Gln Gln Ser Lys Arg Gly Xaa Met Gly Trp Gln Lys Ala 
                165                 170                 175     


Gly His Pro Pro Ser Asp Gly Gln Gln Arg Ala Xaa Gln Gln Gly Ser 
            180                 185                 190         


Leu Arg Xaa Leu Leu Gly Asp Gly Val Gly Arg Gln Gln Pro Arg Ala 
        195                 200                 205             


Lys Gln Val Cys Asn Val Glu Val Gly Leu Gln Xaa Gln Glu Arg Pro 
    210                 215                 220                 


Pro Ala Met Ala Ala Lys His Ser Ser Ser Gly His Cys Val Gln Asn 
225                 230                 235                 240 


Phe Pro Pro Ser Leu Ala Ser Lys Pro Ser Leu Val Gln Gln Lys Pro 
                245                 250                 255     


Xaa Ala Tyr Val Arg Pro Met Asp Gly Gln Asp Gln Ala Pro Asp Glu 
            260                 265                 270         


Ser Pro Lys Leu Lys Ser Ser Ser Glu Xaa Ser Val His Cys Xaa Ser 
        275                 280                 285             


Tyr Arg Gly Val Pro Ala Ser Lys Pro Glu Pro Ala Arg Ala Lys Ala 
    290                 295                 300                 


Lys Leu Ser Lys Phe Ser Ile Pro Lys Gln Gly Glu Glu Ser Arg Ser 
305                 310                 315                 320 


Gly Glu Xaa Asn Ser Cys Val Glu Glu Ile Ile Arg Glu Met Xaa Trp 
                325                 330                 335     


Leu Pro Pro Leu Ser Ala Ile Gln Ala Pro Gly Lys Val Glu Pro Xaa 
            340                 345                 350         


Lys Phe Pro Phe Pro Asn Lys Asp Ser Gln Leu Val Ser Ser Gly His 
        355                 360                 365             


Asn Asn Pro Lys Lys Gly Asp Ala Glu Pro Glu Ser Pro Asp Asn Gly 
    370                 375                 380                 


Xaa Ser Asn Xaa Ser Met Leu Glu Asp Asp Leu Lys Leu Ser Ser Asp 
385                 390                 395                 400 


Glu Glu Glu Asn Glu Gln Gln Ala Ala Gln Arg Xaa Ala Leu Arg Ala 
                405                 410                 415     


Leu Ser Asp Ser Ala Val Val Gln Gln Pro Asn Cys Arg Xaa Ser Val 
            420                 425                 430         


Pro Ser Ser Lys Gly Ser Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser 
        435                 440                 445             


Ser Ser Ser Asp Ser Glu Ser Ser Ser Gly Ser Asp Ser Glu Xaa Glu 
    450                 455                 460                 


Ser Ser Ser Ser Glu Ser Glu Gly Ser Lys Pro Pro His Phe Ser Ser 
465                 470                 475                 480 


Pro Glu Ala Glu Pro Ala Ser Ser Asn Lys Trp Gln Leu Asp Lys Trp 
                485                 490                 495     


Leu Asn Lys Val Asn Pro His Lys Pro Pro Ile Leu Ile Gln Asn Glu 
            500                 505                 510         


Ser His Gly Ser Glu Ser Asn Gln Tyr Tyr Asn Pro Val Lys Glu Asp 
        515                 520                 525             


Val Gln Asp Cys Gly Lys Val Pro Asp Val Cys Gln Pro Ser Leu Arg 
    530                 535                 540                 


Glu Lys Glu Ile Lys Ser Xaa Cys Lys Glu Glu Gln Arg Pro Arg Xaa 
545                 550                 555                 560 


Ala Asn Lys Ala Pro Gly Ser Lys Gly Val Lys Gln Lys Ser Pro Pro 
                565                 570                 575     


Ala Ala Val Ala Val Ala Val Ser Ala Ala Ala Pro Pro Pro Ala Val 
            580                 585                 590         


Pro Cys Ala Pro Ala Glu Asn Ala Pro Ala Pro Ala Arg Arg Ser Ala 
        595                 600                 605             


Gly Lys Lys Pro Xaa Arg Arg Xaa Glu Arg Xaa Ser Ala Gly Asp Gly 
    610                 615                 620                 


Ala Asn Cys His Arg Pro Glu Glu Pro Ala Ala Ala Asp Ala Leu Gly 
625                 630                 635                 640 


Xaa Ser Val Val Val Pro Pro Glu Pro Xaa Lys Xaa Arg Pro Cys Gly 
                645                 650                 655     


Asn Asn Arg Ala Ser His Arg Lys Glu Leu Arg Ser Ser Val Xaa Cys 
            660                 665                 670         


Glu Lys Arg Arg Xaa Arg Gly Leu Ser Arg Ile Val Pro Lys Ser Lys 
        675                 680                 685             


Glu Phe Ile Glu Xaa Glu Ser Ser Ser Ser Ser Ser Ser Ser Asp Ser 
    690                 695                 700                 


Asp Leu Glu Ser Glu Gln Glu Glu Tyr Pro Leu Ser Lys Ala Gln Xaa 
705                 710                 715                 720 


Val Ala Ala Ser Ala Ser Ser Gly Asn Asp Gln Arg Leu Lys Glu Ala 
                725                 730                 735     


Ala Ala Asn Gly Gly Ser Gly Pro Arg Ala Pro Val Gly Ser Ile Asn 
            740                 745                 750         


Ala Arg Xaa Xaa Ser Asp Ile Ala Lys Glu Leu Glu Glu Gln Phe Tyr 
        755                 760                 765             


Xaa Leu Val Pro Phe Gly Arg Asn Glu Leu Leu Ser Pro Leu Lys Asp 
    770                 775                 780                 


Ser Asp Glu Ile Arg Ser Leu Trp Val Lys Ile Asp Leu Xaa Leu Leu 
785                 790                 795                 800 


Ser Arg Ile Pro Glu His Leu Pro Gln Glu Pro Gly Val Leu Ser Ala 
                805                 810                 815     


Pro Ala Xaa Lys Asp Ser Glu Ser Ala Pro Pro Ser His Xaa Ser Asp 
            820                 825                 830         


Xaa Pro Ala Glu Lys Ala Leu Pro Lys Ser Lys Arg Lys Arg Lys Cys 
        835                 840                 845             


Asp Asn Glu Asp Asp Tyr Arg Glu Ile Lys Lys Ser Gln Gly Glu Lys 
    850                 855                 860                 


Asp Ser Ser Ser Arg Leu Ala Xaa Ser Xaa Ser Asn Xaa Leu Ser Ala 
865                 870                 875                 880 


Asn His Cys Asn Met Asn Ile Asn Ser Val Ala Ile Pro Ile Asn Lys 
                885                 890                 895     


Asn Glu Lys Met Leu Arg Ser Pro Ile Ser Pro Leu Ser Asp Ala Ser 
            900                 905                 910         


Lys His Lys Tyr Xaa Ser Glu Asp Leu Xaa Ser Ser Ser Arg Pro Asn 
        915                 920                 925             


Gly Asn Ser Leu Phe Xaa Ser Ala Ser Ser Ser Lys Lys Pro Lys Ala 
    930                 935                 940                 


Asp Ser Gln Leu Gln Pro His Gly Gly Asp Leu Xaa Lys Ala Ala His 
945                 950                 955                 960 


Asn Asn Ser Glu Asn Ile Pro Leu His Lys Ser Arg Pro Gln Xaa Lys 
                965                 970                 975     


Pro Trp Ser Pro Gly Ser Asn Gly His Arg Asp Cys Lys Arg Gln Lys 
            980                 985                 990         


Leu Val Phe Asp Asp Met Pro Arg  Ser Ala Asp Tyr Phe  Met Gln Glu 
        995                 1000                 1005             


Ala Lys  Arg Met Lys His Lys  Ala Asp Ala Met Val  Glu Lys Phe 
    1010                 1015                 1020             


Gly Lys  Ala Leu Asn Tyr Ala  Glu Ala Ala Leu Ser  Phe Ile Glu 
    1025                 1030                 1035             


Cys Gly  Asn Ala Met Glu Gln  Gly Pro Met Glu Ser  Lys Ser Pro 
    1040                 1045                 1050             


Tyr Xaa  Met Tyr Ser Glu Xaa  Val Glu Leu Ile Arg  Tyr Ala Met 
    1055                 1060                 1065             


Arg Leu  Lys Xaa His Ser Gly  Pro Asn Ala Xaa Pro  Glu Asp Lys 
    1070                 1075                 1080             


Gln Leu  Ala Ala Leu Cys Tyr  Arg Cys Leu Ala Leu  Leu Tyr Trp 
    1085                 1090                 1095             


Arg Met  Phe Arg Leu Lys Arg  Asp His Ala Val Lys  Tyr Ser Lys 
    1100                 1105                 1110             


Ala Leu  Ile Asp Tyr Phe Lys  Asn Ser Ser Lys Ala  Ala Gln Ala 
    1115                 1120                 1125             


Pro Ser  Pro Trp Gly Ala Ser  Gly Lys Ser Xaa Gly  Xaa Pro Ser 
    1130                 1135                 1140             


Pro Met  Ser Pro Asn Pro Ser  Pro Ala Ser Ser Val  Gly Ser Gln 
    1145                 1150                 1155             


Gly Ser  Leu Ser Asn Ala Ser  Ala Leu Ser Pro Ser  Xaa Ile Val 
    1160                 1165                 1170             


Ser Ile  Pro Gln Arg Ile His  Gln Met Ala Ala Asn  His Val Ser 
    1175                 1180                 1185             


Ile Xaa  Asn Ser Ile Leu His  Ser Tyr Asp Tyr Trp  Glu Met Ala 
    1190                 1195                 1200             


Asp Asn  Leu Ala Lys Glu Asn  Arg Glu Phe Phe Asn  Asp Leu Asp 
    1205                 1210                 1215             


Leu Leu  Met Gly Pro Val Xaa  Leu His Ser Ser Met  Glu His Leu 
    1220                 1225                 1230             


Val Gln  Tyr Ser Gln Gln Gly  Leu His Trp Leu Arg  Asn Ser Ala 
    1235                 1240                 1245             


His Leu  Ser 
    1250     


<210> 1914
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<400> 1914
Met Ser Lys Lys Leu Ile Xaa Cys Leu Ser Arg Pro Glu Xaa Gly Gly 
1               5                   10                  15      


Lys Phe Glu Val Asp Xaa Gln Arg Pro Val Cys Pro Pro Ser Arg Ala 
            20                  25                  30          


Arg Ala Ala Arg Ala Ser Ala Ala Ala Val Ala Ala Ala Ala Xaa Leu 
        35                  40                  45              


Xaa Pro Pro Xaa Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp 
    50                  55                  60                  


Asp Leu Glu Ser Leu Trp Gly Glu Asp Ile Leu Asn Gln Arg Asn Asp 
65                  70                  75                  80  


Ser Leu Val Val Glu Phe Gln Ser Ser Ala Ser Arg Cys Arg Ser Val 
                85                  90                  95      


Tyr Glu Pro Asp Arg Asn Ala Leu Arg Arg Lys Glu Arg Glu Arg Arg 
            100                 105                 110         


Asn Gln Glu Xaa Gln Gln Asp Asp Gly Xaa Phe Asn Ser Ser Tyr Ser 
        115                 120                 125             


Leu Phe Ser Glu Pro Tyr Lys Xaa Asn Lys Gly Asp Glu Leu Ser Asn 
    130                 135                 140                 


Arg Ile Gln Asn Xaa Leu Gly Asn Tyr Asp Glu 
145                 150                 155 


<210> 1915
<211> 183
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 1915
Met Xaa Leu Arg Leu Asp Ala Gly Gly Ile Pro Ser Leu Ala Pro Arg 
1               5                   10                  15      


Val Tyr Ile Ser Gly Ser Pro Ser Gln Arg Phe Leu Pro Arg Lys Arg 
            20                  25                  30          


Asn Lys Gly Glu Ser Ala Gly Arg Asp Ser Leu Leu Ala Gly Ser Ala 
        35                  40                  45              


Arg Phe Gly Ser Arg Gly Glu Ala Gln Leu Gln Gly Ser Glu Leu Leu 
    50                  55                  60                  


Ser Arg Asn Ser Gly Glu Ser Leu Val Arg Ile Arg Ser Cys Gly Gln 
65                  70                  75                  80  


Glu Leu Ile Xaa Cys Leu Ser Arg Pro Glu Xaa Gly Gly Lys Phe Glu 
                85                  90                  95      


Val Asp Xaa Gln Arg Pro Val Cys Pro Pro Ser Arg Ala Arg Ala Ala 
            100                 105                 110         


Arg Ala Ser Ala Ala Ala Val Ala Ala Ala Ala Xaa Leu Xaa Pro Pro 
        115                 120                 125             


Xaa Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu 
    130                 135                 140                 


Ser Leu Trp Gly Glu Asp Ile Leu Asn Gln Arg Asn Asp Ser Leu Val 
145                 150                 155                 160 


Val Glu Phe Gln Ser Ser Ala Ser Arg Cys Arg Ser Val Tyr Glu Pro 
                165                 170                 175     


Asp Arg Asn Ala Leu Arg Arg 
            180             


<210> 1916
<211> 179
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<400> 1916
Xaa Ala Ser Lys Pro Ser Leu Val Gln Gln Lys Pro Xaa Ala Tyr Val 
1               5                   10                  15      


Arg Pro Met Asp Gly Gln Asp Gln Ala Pro Asp Glu Ser Pro Lys Leu 
            20                  25                  30          


Lys Ser Ser Ser Glu Xaa Ser Val His Cys Xaa Ser Tyr Arg Gly Val 
        35                  40                  45              


Pro Ala Ser Lys Pro Glu Pro Ala Arg Ala Lys Ala Lys Leu Ser Lys 
    50                  55                  60                  


Phe Ser Ile Pro Lys Gln Gly Glu Glu Ser Arg Ser Gly Glu Xaa Asn 
65                  70                  75                  80  


Ser Cys Val Glu Glu Ile Ile Arg Glu Met Xaa Trp Leu Pro Pro Leu 
                85                  90                  95      


Ser Ala Ile Gln Ala Pro Gly Lys Val Glu Pro Xaa Lys Phe Pro Phe 
            100                 105                 110         


Pro Asn Lys Asp Ser Gln Leu Val Ser Ser Gly His Asn Asn Pro Lys 
        115                 120                 125             


Lys Gly Asp Ala Glu Pro Glu Ser Pro Asp Asn Gly Xaa Ser Asn Xaa 
    130                 135                 140                 


Ser Met Leu Glu Asp Asp Leu Lys Leu Ser Ser Asp Glu Glu Glu Asn 
145                 150                 155                 160 


Glu Gln Gln Ala Ala Gln Arg Xaa Ala Leu Arg Ala Leu Ser Asp Ser 
                165                 170                 175     


Leu Ser Trp 
            


<210> 1917
<211> 148
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<400> 1917
Met Asn Arg Glu Asp Arg Asn Val Leu Arg Met Lys Glu Arg Glu Arg 
1               5                   10                  15      


Arg Asn Gln Glu Ile Gln Gln Gly Glu Asp Ala Phe Pro Pro Ser Ser 
            20                  25                  30          


Pro Leu Phe Ala Glu Pro Tyr Lys Val Xaa Ser Lys Glu Asp Lys Leu 
        35                  40                  45              


Ser Ser Arg Ile Gln Ser Met Leu Gly Asn Tyr Asp Glu Met Lys Asp 
    50                  55                  60                  


Phe Ile Gly Asp Arg Ser Ile Pro Lys Leu Val Ala Ile Pro Lys Pro 
65                  70                  75                  80  


Xaa Val Pro Pro Ser Ala Asp Glu Lys Ser Asn Pro Asn Phe Phe Glu 
                85                  90                  95      


Gln Arg His Gly Gly Ser His Gln Ser Ser Lys Trp Xaa Pro Val Gly 
            100                 105                 110         


Pro Ala Pro Ser Xaa Ser Gln Ser Gln Lys Arg Ser Ser Gly Leu Gln 
        115                 120                 125             


Ser Gly His Ser Ser Gln Arg Xaa Ser Ala Gly Ser Ser Ser Gly Xaa 
    130                 135                 140                 


Asn Ser Ser Gly 
145             


<210> 1918
<211> 900
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<400> 1918
Met Asn Arg Glu Asp Arg Asn Val Leu Arg Met Lys Glu Arg Glu Arg 
1               5                   10                  15      


Arg Asn Gln Glu Ile Gln Gln Gly Glu Asp Ala Phe Pro Pro Ser Ser 
            20                  25                  30          


Pro Leu Phe Ala Glu Pro Tyr Lys Val Xaa Ser Lys Glu Asp Lys Leu 
        35                  40                  45              


Ser Ser Arg Ile Gln Ser Met Leu Gly Asn Tyr Asp Glu Met Lys Asp 
    50                  55                  60                  


Phe Ile Gly Asp Arg Ser Ile Pro Lys Leu Val Ala Ile Pro Lys Pro 
65                  70                  75                  80  


Xaa Val Pro Pro Ser Ala Asp Glu Lys Ser Asn Pro Asn Phe Phe Glu 
                85                  90                  95      


Gln Arg His Gly Gly Ser His Gln Ser Ser Lys Trp Xaa Pro Val Gly 
            100                 105                 110         


Pro Ala Pro Ser Xaa Ser Gln Ser Gln Lys Arg Ser Ser Gly Leu Gln 
        115                 120                 125             


Ser Gly His Ser Ser Gln Arg Xaa Ser Ala Gly Ser Ser Ser Gly Xaa 
    130                 135                 140                 


Asn Ser Ser Gly Gln Arg His Asp Arg Glu Ser Tyr Asn Asn Ser Gly 
145                 150                 155                 160 


Ser Ser Ser Arg Lys Lys Gly Gln His Gly Ser Glu His Ser Lys Ser 
                165                 170                 175     


Arg Ser Ser Ser Pro Gly Lys Pro Gln Ala Val Ser Ser Leu Asn Ser 
            180                 185                 190         


Ser His Ser Arg Ser His Gly Asn Asp His His Ser Lys Glu His Gln 
        195                 200                 205             


Arg Ser Lys Ser Pro Arg Asp Pro Asp Ala Asn Trp Asp Ser Pro Ser 
    210                 215                 220                 


Arg Val Pro Phe Ser Ser Gly Gln His Ser Xaa Gln Ser Phe Pro Pro 
225                 230                 235                 240 


Ser Leu Met Ser Lys Ser Asn Ser Met Leu Gln Lys Pro Xaa Ala Tyr 
                245                 250                 255     


Val Arg Pro Met Asp Gly Gln Glu Ser Met Glu Pro Lys Leu Ser Ser 
            260                 265                 270         


Glu His Tyr Ser Ser Gln Ser His Gly Asn Ser Met Xaa Glu Leu Lys 
        275                 280                 285             


Pro Ser Ser Lys Ala His Leu Xaa Lys Leu Lys Ile Pro Ser Gln Pro 
    290                 295                 300                 


Leu Asp Ala Ser Ala Ser Gly Asp Val Ser Cys Val Asp Glu Ile Leu 
305                 310                 315                 320 


Lys Glu Met Xaa His Ser Trp Pro Pro Pro Leu Xaa Ala Ile His Xaa 
                325                 330                 335     


Pro Cys Lys Xaa Glu Pro Ser Lys Phe Pro Phe Pro Xaa Lys Glu Ser 
            340                 345                 350         


Gln Gln Ser Asn Phe Gly Xaa Gly Glu Gln Lys Arg Tyr Asn Pro Ser 
        355                 360                 365             


Lys Xaa Ser Asn Gly His Gln Ser Lys Ser Met Leu Lys Asp Asp Leu 
    370                 375                 380                 


Lys Leu Ser Ser Ser Glu Asp Ser Asp Gly Glu Gln Asp Cys Asp Lys 
385                 390                 395                 400 


Xaa Met Pro Arg Ser Xaa Pro Gly Ser Asn Ser Glu Pro Ser His His 
                405                 410                 415     


Asn Ser Glu Gly Ala Asp Asn Ser Arg Asp Asp Ser Ser Ser His Ser 
            420                 425                 430         


Gly Ser Glu Ser Ser Ser Gly Ser Asp Ser Glu Ser Glu Ser Ser Ser 
        435                 440                 445             


Ser Asp Ser Glu Ala Asn Glu Pro Ser Gln Ser Ala Ser Pro Glu Pro 
    450                 455                 460                 


Glu Pro Pro Pro Xaa Asn Lys Trp Gln Leu Asp Asn Trp Leu Asn Lys 
465                 470                 475                 480 


Val Asn Pro His Lys Val Ser Pro Ala Ser Ser Val Asp Ser Asn Ile 
                485                 490                 495     


Pro Ser Ser Gln Gly Tyr Lys Lys Glu Gly Arg Glu Gln Gly Xaa Gly 
            500                 505                 510         


Asn Ser Tyr Xaa Asp Xaa Ser Gly Pro Lys Glu Xaa Ser Ser Ala Xaa 
        515                 520                 525             


Pro Gly Arg Asp Ser Lys Xaa Ile Gln Lys Gly Ser Glu Ser Gly Arg 
    530                 535                 540                 


Gly Arg Gln Lys Ser Pro Ala Gln Ser Asp Ser Xaa Xaa Gln Arg Arg 
545                 550                 555                 560 


Xaa Val Gly Lys Lys Gln Pro Lys Lys Ala Glu Lys Ala Ala Ala Glu 
                565                 570                 575     


Glu Pro Arg Gly Gly Leu Lys Ile Glu Ser Glu Xaa Pro Val Asp Leu 
            580                 585                 590         


Ala Ser Ser Met Pro Ser Ser Arg His Lys Ala Ala Xaa Lys Gly Ser 
        595                 600                 605             


Arg Lys Pro Asn Ile Lys Lys Glu Ser Lys Ser Ser Pro Arg Pro Xaa 
    610                 615                 620                 


Ala Glu Lys Lys Lys Tyr Lys Ser Xaa Ser Lys Ser Ser Gln Lys Ser 
625                 630                 635                 640 


Arg Glu Ile Ile Glu Xaa Asp Xaa Ser Ser Ser Asp Ser Asp Glu Ser 
                645                 650                 655     


Glu Ser Leu Pro Pro Ser Ser Gln Xaa Pro Lys Tyr Pro Glu Ser Asn 
            660                 665                 670         


Arg Xaa Pro Val Lys Pro Ser Ser Val Glu Glu Glu Asp Ser Phe Phe 
        675                 680                 685             


Arg Gln Arg Met Phe Ser Pro Met Glu Glu Lys Glu Leu Leu Ser Pro 
    690                 695                 700                 


Leu Ser Glu Pro Asp Asp Arg Tyr Pro Leu Ile Val Lys Ile Asp Leu 
705                 710                 715                 720 


Asn Leu Leu Xaa Arg Ile Pro Gly Lys Pro Tyr Lys Glu Xaa Glu Pro 
                725                 730                 735     


Pro Lys Gly Glu Lys Lys Asn Val Pro Glu Lys His Xaa Arg Glu Ala 
            740                 745                 750         


Gln Lys Gln Ala Ser Glu Lys Val Ser Asn Lys Gly Lys Arg Lys His 
        755                 760                 765             


Lys Asn Glu Asp Asp Asn Arg Ala Ser Glu Ser Lys Lys Pro Lys Xaa 
    770                 775                 780                 


Glu Asp Lys Asn Ser Ala Gly His Lys Pro Ser Ser Asn Arg Glu Ser 
785                 790                 795                 800 


Ser Lys Gln Ser Ala Ala Lys Glu Lys Asp Leu Leu Pro Ser Pro Ala 
                805                 810                 815     


Gly Pro Val Pro Ser Lys Asp Pro Lys Xaa Glu His Gly Ser Arg Lys 
            820                 825                 830         


Arg Xaa Ile Ser Gln Ser Ser Ser Leu Lys Ser Ser Ser Asn Ser Asn 
        835                 840                 845             


Lys Glu Xaa Ser Gly Ser Ser Lys Asn Ser Ser Ser Xaa Ser Lys Gln 
    850                 855                 860                 


Lys Lys Xaa Glu Gly Lys Xaa Ser Ser Ser Ser Lys Glu Val Lys Val 
865                 870                 875                 880 


Lys Cys Trp Gly Pro Gly Ala Phe Glu Asn His Ser Xaa Cys His Val 
                885                 890                 895     


Xaa Phe Pro Gly 
            900 


<210> 1919
<211> 1163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1107)..(1107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<400> 1919
Met Asn Arg Glu Asp Arg Asn Val Leu Arg Met Lys Glu Arg Glu Arg 
1               5                   10                  15      


Arg Asn Gln Glu Ile Gln Gln Gly Glu Asp Ala Phe Pro Pro Ser Ser 
            20                  25                  30          


Pro Leu Phe Ala Glu Pro Tyr Lys Val Xaa Ser Lys Glu Asp Lys Leu 
        35                  40                  45              


Ser Ser Arg Ile Gln Ser Met Leu Gly Asn Tyr Asp Glu Met Lys Asp 
    50                  55                  60                  


Phe Ile Gly Asp Arg Ser Ile Pro Lys Leu Val Ala Ile Pro Lys Pro 
65                  70                  75                  80  


Xaa Val Pro Pro Ser Ala Asp Glu Lys Ser Asn Pro Asn Phe Phe Glu 
                85                  90                  95      


Gln Arg His Gly Gly Ser His Gln Ser Ser Lys Trp Xaa Pro Val Gly 
            100                 105                 110         


Pro Ala Pro Ser Xaa Ser Gln Ser Gln Lys Arg Ser Ser Gly Leu Gln 
        115                 120                 125             


Ser Gly His Ser Ser Gln Arg Xaa Ser Ala Gly Ser Ser Ser Gly Xaa 
    130                 135                 140                 


Asn Ser Ser Gly Gln Arg His Asp Arg Glu Ser Tyr Asn Asn Ser Gly 
145                 150                 155                 160 


Ser Ser Ser Arg Lys Lys Gly Gln His Gly Ser Glu His Ser Lys Ser 
                165                 170                 175     


Arg Ser Ser Ser Pro Gly Lys Pro Gln Ala Val Ser Ser Leu Asn Ser 
            180                 185                 190         


Ser His Ser Arg Ser His Gly Asn Asp His His Ser Lys Glu His Gln 
        195                 200                 205             


Arg Ser Lys Ser Pro Arg Asp Pro Asp Ala Asn Trp Asp Ser Pro Ser 
    210                 215                 220                 


Arg Val Pro Phe Ser Ser Gly Gln His Ser Xaa Gln Ser Phe Pro Pro 
225                 230                 235                 240 


Ser Leu Met Ser Lys Ser Asn Ser Met Leu Gln Lys Pro Xaa Ala Tyr 
                245                 250                 255     


Val Arg Pro Met Asp Gly Gln Glu Ser Met Glu Pro Lys Leu Ser Ser 
            260                 265                 270         


Glu His Tyr Ser Ser Gln Ser His Gly Asn Ser Met Xaa Glu Leu Lys 
        275                 280                 285             


Pro Ser Ser Lys Ala His Leu Xaa Lys Leu Lys Ile Pro Ser Gln Pro 
    290                 295                 300                 


Leu Asp Ala Ser Ala Ser Gly Asp Val Ser Cys Val Asp Glu Ile Leu 
305                 310                 315                 320 


Lys Glu Met Xaa His Ser Trp Pro Pro Pro Leu Xaa Ala Ile His Xaa 
                325                 330                 335     


Pro Cys Lys Xaa Glu Pro Ser Lys Phe Pro Phe Pro Xaa Lys Glu Ser 
            340                 345                 350         


Gln Gln Ser Asn Phe Gly Xaa Gly Glu Gln Lys Arg Tyr Asn Pro Ser 
        355                 360                 365             


Lys Xaa Ser Asn Gly His Gln Ser Lys Ser Met Leu Lys Asp Asp Leu 
    370                 375                 380                 


Lys Leu Ser Ser Ser Glu Asp Ser Asp Gly Glu Gln Asp Cys Asp Lys 
385                 390                 395                 400 


Xaa Met Pro Arg Ser Xaa Pro Gly Ser Asn Ser Glu Pro Ser His His 
                405                 410                 415     


Asn Ser Glu Gly Ala Asp Asn Ser Arg Asp Asp Ser Ser Ser His Ser 
            420                 425                 430         


Gly Ser Glu Ser Ser Ser Gly Ser Asp Ser Glu Ser Glu Ser Ser Ser 
        435                 440                 445             


Ser Asp Ser Glu Ala Asn Glu Pro Ser Gln Ser Ala Ser Pro Glu Pro 
    450                 455                 460                 


Glu Pro Pro Pro Xaa Asn Lys Trp Gln Leu Asp Asn Trp Leu Asn Lys 
465                 470                 475                 480 


Val Asn Pro His Lys Val Ser Pro Ala Ser Ser Val Asp Ser Asn Ile 
                485                 490                 495     


Pro Ser Ser Gln Gly Tyr Lys Lys Glu Gly Arg Glu Gln Gly Xaa Gly 
            500                 505                 510         


Asn Ser Tyr Xaa Asp Xaa Ser Gly Pro Lys Glu Xaa Ser Ser Ala Xaa 
        515                 520                 525             


Pro Gly Arg Asp Ser Lys Xaa Ile Gln Lys Gly Ser Glu Ser Gly Arg 
    530                 535                 540                 


Gly Arg Gln Lys Ser Pro Ala Gln Ser Asp Ser Xaa Xaa Gln Arg Arg 
545                 550                 555                 560 


Xaa Val Gly Lys Lys Gln Pro Lys Lys Ala Glu Lys Ala Ala Ala Glu 
                565                 570                 575     


Glu Pro Arg Gly Gly Leu Lys Ile Glu Ser Glu Xaa Pro Val Asp Leu 
            580                 585                 590         


Ala Ser Ser Met Pro Ser Ser Arg His Lys Ala Ala Xaa Lys Gly Ser 
        595                 600                 605             


Arg Lys Pro Asn Ile Lys Lys Glu Ser Lys Ser Ser Pro Arg Pro Xaa 
    610                 615                 620                 


Ala Glu Lys Lys Lys Tyr Lys Ser Xaa Ser Lys Ser Ser Gln Lys Ser 
625                 630                 635                 640 


Arg Glu Ile Ile Glu Xaa Asp Xaa Ser Ser Ser Asp Ser Asp Glu Ser 
                645                 650                 655     


Glu Ser Leu Pro Pro Ser Ser Gln Xaa Pro Lys Tyr Pro Glu Ser Asn 
            660                 665                 670         


Arg Xaa Pro Val Lys Pro Ser Ser Val Glu Glu Glu Asp Ser Phe Phe 
        675                 680                 685             


Arg Gln Arg Met Phe Ser Pro Met Glu Glu Lys Glu Leu Leu Ser Pro 
    690                 695                 700                 


Leu Ser Glu Pro Asp Asp Arg Tyr Pro Leu Ile Val Lys Ile Asp Leu 
705                 710                 715                 720 


Asn Leu Leu Xaa Arg Ile Pro Gly Lys Pro Tyr Lys Glu Xaa Glu Pro 
                725                 730                 735     


Pro Lys Gly Glu Lys Lys Asn Val Pro Glu Lys His Xaa Arg Glu Ala 
            740                 745                 750         


Gln Lys Gln Ala Ser Glu Lys Val Ser Asn Lys Gly Lys Arg Lys His 
        755                 760                 765             


Lys Asn Glu Asp Asp Asn Arg Ala Ser Glu Ser Lys Lys Pro Lys Xaa 
    770                 775                 780                 


Glu Asp Lys Asn Ser Ala Gly His Lys Pro Ser Ser Asn Arg Glu Ser 
785                 790                 795                 800 


Ser Lys Gln Ser Ala Ala Lys Glu Lys Asp Leu Leu Pro Ser Pro Ala 
                805                 810                 815     


Gly Pro Val Pro Ser Lys Asp Pro Lys Xaa Glu His Gly Ser Arg Lys 
            820                 825                 830         


Arg Xaa Ile Ser Gln Ser Ser Ser Leu Lys Ser Ser Ser Asn Ser Asn 
        835                 840                 845             


Lys Glu Xaa Ser Gly Ser Ser Lys Asn Ser Ser Ser Xaa Ser Lys Gln 
    850                 855                 860                 


Lys Lys Xaa Glu Gly Lys Xaa Ser Ser Ser Ser Lys Glu Val Lys Glu 
865                 870                 875                 880 


Lys Ala Pro Ser Ser Ser Ser Asn Cys Pro Pro Ser Ala Pro Xaa Leu 
                885                 890                 895     


Asp Ser Ser Lys Pro Arg Arg Xaa Lys Leu Val Phe Asp Asp Arg Asn 
            900                 905                 910         


Tyr Ser Ala Asp His Tyr Leu Gln Glu Ala Lys Lys Leu Lys His Asn 
        915                 920                 925             


Ala Asp Ala Leu Ser Asp Arg Phe Glu Lys Ala Val Tyr Tyr Leu Asp 
    930                 935                 940                 


Ala Val Val Ser Phe Ile Glu Cys Gly Asn Ala Leu Glu Lys Asn Ala 
945                 950                 955                 960 


Gln Glu Ser Lys Ser Pro Phe Pro Met Tyr Ser Glu Xaa Val Asp Leu 
                965                 970                 975     


Ile Lys Tyr Xaa Met Lys Leu Lys Asn Tyr Leu Ala Pro Asp Ala Xaa 
            980                 985                 990         


Ala Ala Asp Lys Arg Leu Xaa Val  Leu Cys Leu Arg Cys  Glu Ser Leu 
        995                 1000                 1005             


Leu Tyr  Leu Arg Leu Phe Lys  Leu Lys Lys Glu Asn  Ala Leu Lys 
    1010                 1015                 1020             


Tyr Ser  Lys Xaa Leu Xaa Glu  His Leu Lys Asn Ser  Tyr Asn Asn 
    1025                 1030                 1035             


Ser Gln  Ala Pro Ser Pro Gly  Leu Gly Ser Lys Ala  Val Gly Met 
    1040                 1045                 1050             


Pro Ser  Pro Val Ser Pro Lys  Leu Ser Pro Gly Asn  Ser Gly Asn 
    1055                 1060                 1065             


Tyr Ser  Ser Gly Ala Ser Ser  Ala Ser Ala Ser Gly  Ser Ser Val 
    1070                 1075                 1080             


Xaa Ile  Pro Gln Lys Ile His  Gln Met Ala Ala Ser  Tyr Val Gln 
    1085                 1090                 1095             


Val Xaa  Ser Asn Phe Leu Tyr  Ala Xaa Glu Ile Trp  Asp Gln Ala 
    1100                 1105                 1110             


Glu Gln  Leu Ser Lys Glu Gln  Lys Glu Phe Phe Ala  Glu Leu Asp 
    1115                 1120                 1125             


Lys Val  Met Gly Pro Leu Ile  Phe Asn Ala Ser Ile  Met Xaa Asp 
    1130                 1135                 1140             


Leu Val  Arg Tyr Xaa Arg Gln  Gly Leu His Trp Leu  Arg Gln Asp 
    1145                 1150                 1155             


Ala Lys  Leu Ile Ser 
    1160             


<210> 1920
<211> 171
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 1920
Xaa Ser Gln Ser His Gly Asn Ser Met Xaa Glu Leu Lys Pro Ser Ser 
1               5                   10                  15      


Lys Ala His Leu Xaa Lys Leu Lys Ile Pro Ser Gln Pro Leu Asp Ala 
            20                  25                  30          


Ser Ala Ser Gly Asp Val Ser Cys Val Asp Glu Ile Leu Lys Glu Ser 
        35                  40                  45              


Gln Gln Ser Asn Phe Gly Xaa Gly Glu Gln Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Lys Xaa Ser Asn Gly His Gln Ser Lys Ser Met Leu Lys Asp Asp Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Ser Glu Asp Ser Asp Gly Glu Gln Asp Cys Asp Lys 
                85                  90                  95      


Xaa Met Pro Arg Ser Xaa Pro Gly Ser Asn Ser Glu Pro Ser His His 
            100                 105                 110         


Asn Ser Glu Gly Ala Asp Asn Ser Arg Asp Asp Ser Ser Ser His Ser 
        115                 120                 125             


Gly Ser Glu Ser Ser Ser Gly Ser Asp Ser Glu Ser Glu Ser Ser Ser 
    130                 135                 140                 


Ser Asp Ser Glu Ala Asn Glu Pro Ser Gln Ser Ala Ser Pro Glu Pro 
145                 150                 155                 160 


Glu Pro Pro Pro Xaa Asn Lys Trp Gln Leu Asp 
                165                 170     


<210> 1921
<211> 609
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<400> 1921
Met Lys Trp Val Glu Ser Ile Phe Leu Ile Phe Leu Leu Asn Phe Xaa 
1               5                   10                  15      


Glu Ser Arg Xaa Leu His Arg Asn Glu Tyr Gly Ile Ala Ser Ile Leu 
            20                  25                  30          


Asp Ser Tyr Gln Cys Xaa Ala Glu Ile Ser Leu Ala Asp Leu Ala Xaa 
        35                  40                  45              


Ile Phe Phe Ala Gln Phe Val Gln Glu Ala Xaa Tyr Lys Glu Val Ser 
    50                  55                  60                  


Lys Met Val Lys Asp Ala Leu Xaa Ala Ile Glu Lys Pro Xaa Gly Asp 
65                  70                  75                  80  


Glu Gln Ser Ser Gly Cys Leu Glu Asn Gln Leu Pro Ala Phe Leu Glu 
                85                  90                  95      


Glu Leu Cys His Glu Lys Glu Ile Leu Glu Lys Tyr Gly His Ser Asp 
            100                 105                 110         


Cys Cys Ser Gln Ser Glu Glu Gly Arg His Asn Cys Phe Leu Ala His 
        115                 120                 125             


Lys Lys Pro Xaa Pro Ala Ser Ile Pro Leu Phe Gln Val Pro Glu Pro 
    130                 135                 140                 


Val Xaa Ser Cys Glu Ala Tyr Glu Glu Asp Arg Glu Xaa Phe Met Asn 
145                 150                 155                 160 


Lys Phe Ile Tyr Glu Ile Ala Arg Arg His Pro Phe Leu Tyr Ala Pro 
                165                 170                 175     


Xaa Ile Leu Leu Trp Ala Ala Arg Tyr Asp Lys Ile Ile Pro Ser Cys 
            180                 185                 190         


Cys Lys Ala Glu Asn Ala Val Glu Cys Phe Gln Xaa Lys Ala Ala Xaa 
        195                 200                 205             


Val Xaa Lys Glu Leu Arg Glu Ser Ser Leu Leu Asn Gln His Ala Cys 
    210                 215                 220                 


Ala Val Met Lys Asn Phe Gly Xaa Arg Xaa Phe Gln Ala Ile Xaa Val 
225                 230                 235                 240 


Xaa Lys Leu Ser Gln Lys Phe Xaa Lys Val Asn Phe Xaa Glu Ile Gln 
                245                 250                 255     


Lys Leu Val Leu Asp Val Ala His Val His Glu His Cys Cys Arg Gly 
            260                 265                 270         


Asp Val Leu Asp Cys Leu Gln Asp Gly Glu Lys Ile Met Ser Tyr Ile 
        275                 280                 285             


Cys Ser Gln Gln Asp Xaa Leu Ser Asn Lys Ile Xaa Glu Cys Cys Lys 
    290                 295                 300                 


Leu Xaa Xaa Leu Glu Arg Gly Gln Cys Ile Ile His Ala Glu Asn Asp 
305                 310                 315                 320 


Glu Lys Pro Glu Gly Leu Ser Pro Asn Leu Asn Arg Phe Leu Gly Asp 
                325                 330                 335     


Arg Asp Phe Asn Gln Phe Ser Ser Gly Glu Lys Asn Ile Phe Leu Ala 
            340                 345                 350         


Ser Phe Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala Val Ser 
        355                 360                 365             


Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu Glu Lys Cys 
    370                 375                 380                 


Phe Gln Xaa Glu Asn Pro Leu Glu Cys Gln Asp Lys Gly Glu Glu Glu 
385                 390                 395                 400 


Leu Gln Lys Tyr Ile Gln Glu Ser Gln Ala Leu Ala Lys Arg Ser Cys 
                405                 410                 415     


Gly Leu Phe Gln Lys Leu Gly Glu Tyr Tyr Leu Gln Asn Ala Phe Leu 
            420                 425                 430         


Val Ala Tyr Xaa Lys Lys Ala Pro Gln Leu Xaa Ser Ser Glu Leu Met 
        435                 440                 445             


Ala Ile Xaa Arg Lys Met Ala Ala Xaa Ala Ala Xaa Cys Cys Gln Leu 
    450                 455                 460                 


Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile Ile 
465                 470                 475                 480 


Ile Gly His Leu Cys Ile Arg His Glu Met Xaa Pro Val Asn Pro Gly 
                485                 490                 495     


Val Gly Gln Cys Cys Xaa Ser Ser Tyr Ala Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ser Leu Val Val Asp Glu Xaa Tyr Val Pro Pro Ala Phe Ser Asp 
        515                 520                 525             


Asp Lys Phe Ile Phe His Lys Asp Leu Cys Gln Ala Gln Gly Val Ala 
    530                 535                 540                 


Leu Gln Xaa Met Lys Gln Glu Phe Leu Ile Asn Leu Val Lys Gln Lys 
545                 550                 555                 560 


Pro Gln Ile Xaa Glu Glu Gln Leu Glu Ala Val Ile Ala Asp Phe Ser 
                565                 570                 575     


Gly Leu Leu Glu Lys Cys Cys Gln Gly Gln Glu Gln Glu Val Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Gln Lys Leu Ile Ser Lys Xaa Arg Ala Ala Leu Gly 
        595                 600                 605             


Val 
    


<210> 1922
<211> 622
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<400> 1922
Met Lys Trp Val Glu Ser Ile Phe Leu Ile Phe Leu Leu Asn Phe Xaa 
1               5                   10                  15      


Glu Ser Arg Xaa Leu His Arg Asn Glu Tyr Gly Ile Ala Ser Ile Leu 
            20                  25                  30          


Asp Ser Tyr Gln Cys Xaa Ala Glu Ile Ser Leu Ala Asp Leu Ala Xaa 
        35                  40                  45              


Ile Phe Phe Ala Gln Phe Val Gln Glu Ala Xaa Tyr Lys Glu Val Ser 
    50                  55                  60                  


Lys Met Val Lys Asp Ala Leu Xaa Ala Ile Glu Lys Pro Xaa Gly Asp 
65                  70                  75                  80  


Glu Gln Ser Ser Gly Cys Leu Glu Asn Gln Leu Pro Ala Phe Leu Glu 
                85                  90                  95      


Glu Leu Cys His Glu Lys Glu Ile Leu Glu Lys Tyr Gly His Ser Asp 
            100                 105                 110         


Cys Cys Ser Gln Ser Glu Glu Gly Arg His Asn Cys Phe Leu Ala His 
        115                 120                 125             


Lys Lys Pro Xaa Pro Ala Ser Ile Pro Leu Phe Gln Val Pro Glu Pro 
    130                 135                 140                 


Val Xaa Ser Cys Glu Ala Tyr Glu Glu Asp Arg Glu Xaa Phe Met Asn 
145                 150                 155                 160 


Lys Phe Ile Tyr Glu Ile Ala Arg Arg His Pro Phe Leu Tyr Ala Pro 
                165                 170                 175     


Xaa Ile Leu Leu Trp Ala Ala Arg Tyr Asp Lys Ile Ile Pro Ser Cys 
            180                 185                 190         


Cys Lys Ala Glu Asn Ala Val Glu Cys Phe Gln Xaa Lys Ala Ala Xaa 
        195                 200                 205             


Val Xaa Lys Glu Leu Arg Glu Ser Ser Leu Leu Asn Gln His Ala Cys 
    210                 215                 220                 


Ala Val Met Lys Asn Phe Gly Xaa Arg Xaa Phe Gln Ala Ile Xaa Val 
225                 230                 235                 240 


Xaa Lys Leu Ser Gln Lys Phe Xaa Lys Val Asn Phe Xaa Glu Ile Gln 
                245                 250                 255     


Lys Leu Val Leu Asp Val Ala His Val His Glu His Cys Cys Arg Gly 
            260                 265                 270         


Asp Val Leu Asp Cys Leu Gln Asp Gly Glu Lys Ile Met Ser Tyr Ile 
        275                 280                 285             


Cys Ser Gln Gln Asp Xaa Leu Ser Asn Lys Ile Xaa Glu Cys Cys Lys 
    290                 295                 300                 


Leu Xaa Xaa Leu Glu Arg Gly Gln Cys Ile Ile His Ala Glu Asn Asp 
305                 310                 315                 320 


Glu Lys Pro Glu Gly Leu Ser Pro Asn Leu Asn Arg Phe Leu Gly Asp 
                325                 330                 335     


Arg Asp Phe Asn Gln Phe Ser Ser Gly Glu Lys Asn Ile Phe Leu Ala 
            340                 345                 350         


Ser Phe Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala Val Ser 
        355                 360                 365             


Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu Glu Lys Cys 
    370                 375                 380                 


Phe Gln Xaa Glu Asn Pro Leu Glu Cys Gln Asp Lys Gly Glu Glu Glu 
385                 390                 395                 400 


Leu Gln Lys Tyr Ile Gln Glu Ser Gln Ala Leu Ala Lys Arg Ser Cys 
                405                 410                 415     


Gly Leu Phe Gln Lys Leu Gly Glu Tyr Tyr Leu Gln Asn Ala Phe Leu 
            420                 425                 430         


Val Ala Tyr Xaa Lys Lys Ala Pro Gln Leu Xaa Ser Ser Glu Leu Met 
        435                 440                 445             


Ala Ile Xaa Arg Lys Met Ala Ala Xaa Ala Ala Xaa Cys Cys Gln Leu 
    450                 455                 460                 


Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile Ile 
465                 470                 475                 480 


Ile Gly His Leu Cys Ile Arg His Glu Met Xaa Pro Val Asn Pro Gly 
                485                 490                 495     


Val Gly Gln Cys Cys Xaa Ser Ser Tyr Ala Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ser Leu Val Val Asp Glu Xaa Tyr Val Pro Pro Ala Phe Ser Asp 
        515                 520                 525             


Asp Lys Phe Ile Phe His Lys Asp Leu Cys Gln Ala Gln Gly Val Ala 
    530                 535                 540                 


Leu Gln Xaa Met Lys Gln Glu Phe Leu Ile Asn Leu Val Lys Gln Lys 
545                 550                 555                 560 


Pro Gln Ile Xaa Glu Glu Gln Leu Glu Ala Val Ile Ala Asp Phe Ser 
                565                 570                 575     


Gly Leu Leu Glu Lys Cys Cys Gln Gly Gln Glu Gln Glu Val Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Arg Arg Gln Asn Glu Ser Phe Ile Arg Cys Glu 
        595                 600                 605             


Leu Phe Ser Leu Ile Leu Xaa Asp Leu Xaa Leu Phe Val Asn 
    610                 615                 620         


<210> 1923
<211> 351
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<400> 1923
Asp Ala Phe Val Asn Ser Gln Glu Trp Xaa Leu Ser Arg Ser Val Pro 
1               5                   10                  15      


Glu Leu Lys Val Gly Ile Val Gly Asn Leu Ala Ser Gly Lys Ser Ala 
            20                  25                  30          


Leu Val His Arg Tyr Leu Xaa Gly Xaa Tyr Val Gln Glu Glu Ser Pro 
        35                  40                  45              


Glu Gly Gly Arg Phe Lys Lys Glu Ile Val Val Asp Gly Gln Ser Tyr 
    50                  55                  60                  


Leu Leu Leu Ile Arg Asp Glu Gly Gly Pro Pro Glu Ala Gln Phe Ala 
65                  70                  75                  80  


Met Trp Val Asp Ala Val Ile Phe Val Phe Ser Leu Glu Asp Glu Ile 
                85                  90                  95      


Ser Phe Gln Xaa Val Tyr His Tyr Tyr Ser Arg Met Ala Asn Tyr Arg 
            100                 105                 110         


Asn Xaa Ser Glu Ile Pro Leu Val Leu Val Gly Xaa Gln Asp Ala Ile 
        115                 120                 125             


Ser Ser Ala Asn Pro Arg Val Ile Asp Asp Ala Arg Ala Arg Lys Leu 
    130                 135                 140                 


Ser Asn Asp Leu Lys Arg Cys Xaa Tyr Tyr Glu Xaa Cys Ala Xaa Tyr 
145                 150                 155                 160 


Gly Leu Asn Val Glu Arg Val Phe Gln Asp Val Ala Gln Lys Ile Val 
                165                 170                 175     


Ala Xaa Arg Lys Lys Gln Gln Leu Ser Ile Gly Pro Cys Lys Ser Leu 
            180                 185                 190         


Pro Asn Ser Pro Ser His Ser Ser Val Cys Ser Ala Gln Val Ser Ala 
        195                 200                 205             


Val His Ile Ser Gln Xaa Ser Asn Gly Gly Gly Ser Leu Ser Asp Tyr 
    210                 215                 220                 


Ser Ser Ser Val Pro Ser Xaa Pro Ser Xaa Ser Gln Lys Glu Leu Arg 
225                 230                 235                 240 


Ile Asp Val Pro Pro Xaa Ala Asn Xaa Pro Xaa Pro Val Arg Lys Gln 
                245                 250                 255     


Ser Lys Arg Arg Ser Asn Leu Phe Xaa Ser Arg Lys Gly Ser Asp Pro 
            260                 265                 270         


Asp Lys Glu Lys Lys Gly Leu Glu Ser Arg Ala Asp Ser Ile Gly Ser 
        275                 280                 285             


Gly Arg Ala Ile Pro Ile Lys Gln Gly Leu Pro Phe Phe Val Leu Ala 
    290                 295                 300                 


Leu Xaa Ala Ser Xaa Tyr Leu Arg Pro Ala Gly Ala Arg Ala Arg Gln 
305                 310                 315                 320 


Ser Ser Pro Trp Pro Gly Pro Arg Gly Gly Gln Xaa Ser Pro His Cys 
                325                 330                 335     


Ala Glu Gly Pro Gln Ser Ala Gln Leu Ser Gly Ala Met Met Asn 
            340                 345                 350     


<210> 1924
<211> 750
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<400> 1924
Asp Ala Phe Val Asn Ser Gln Glu Trp Xaa Leu Ser Arg Ser Val Pro 
1               5                   10                  15      


Glu Leu Lys Val Gly Ile Val Gly Asn Leu Ala Ser Gly Lys Ser Ala 
            20                  25                  30          


Leu Val His Arg Tyr Leu Xaa Gly Xaa Tyr Val Gln Glu Glu Ser Pro 
        35                  40                  45              


Glu Gly Gly Arg Phe Lys Lys Glu Ile Val Val Asp Gly Gln Ser Tyr 
    50                  55                  60                  


Leu Leu Leu Ile Arg Asp Glu Gly Gly Pro Pro Glu Ala Gln Phe Ala 
65                  70                  75                  80  


Met Trp Val Asp Ala Val Ile Phe Val Phe Ser Leu Glu Asp Glu Ile 
                85                  90                  95      


Ser Phe Gln Xaa Val Tyr His Tyr Tyr Ser Arg Met Ala Asn Tyr Arg 
            100                 105                 110         


Asn Xaa Ser Glu Ile Pro Leu Val Leu Val Gly Xaa Gln Asp Ala Ile 
        115                 120                 125             


Ser Ser Ala Asn Pro Arg Val Ile Asp Asp Ala Arg Ala Arg Lys Leu 
    130                 135                 140                 


Ser Asn Asp Leu Lys Arg Cys Xaa Tyr Tyr Glu Xaa Cys Ala Xaa Tyr 
145                 150                 155                 160 


Gly Leu Asn Val Glu Arg Val Phe Gln Asp Val Ala Gln Lys Ile Val 
                165                 170                 175     


Ala Xaa Arg Lys Lys Gln Gln Leu Ser Ile Gly Pro Cys Lys Ser Leu 
            180                 185                 190         


Pro Asn Ser Pro Ser His Ser Ser Val Cys Ser Ala Gln Val Ser Ala 
        195                 200                 205             


Val His Ile Ser Gln Xaa Ser Asn Gly Gly Gly Ser Leu Ser Asp Tyr 
    210                 215                 220                 


Ser Ser Ser Val Pro Ser Xaa Pro Ser Xaa Ser Gln Lys Glu Leu Arg 
225                 230                 235                 240 


Ile Asp Val Pro Pro Xaa Ala Asn Xaa Pro Xaa Pro Val Arg Lys Gln 
                245                 250                 255     


Ser Lys Arg Arg Ser Asn Leu Phe Xaa Ser Arg Lys Gly Ser Asp Pro 
            260                 265                 270         


Asp Lys Glu Lys Lys Gly Leu Glu Ser Arg Ala Asp Ser Ile Gly Ser 
        275                 280                 285             


Gly Arg Ala Ile Pro Ile Lys Gln Gly Met Leu Leu Lys Arg Ser Gly 
    290                 295                 300                 


Lys Ser Leu Asn Lys Glu Trp Lys Lys Lys Tyr Val Xaa Leu Cys Asp 
305                 310                 315                 320 


Asn Gly Val Leu Xaa Tyr His Pro Ser Leu His Asp Tyr Met Gln Asn 
                325                 330                 335     


Val His Gly Lys Glu Ile Asp Leu Leu Arg Xaa Xaa Val Lys Val Pro 
            340                 345                 350         


Gly Lys Arg Pro Pro Arg Ala Xaa Ser Ala Cys Ala Pro Ile Ser Ser 
        355                 360                 365             


Pro Lys Xaa Asn Gly Leu Ser Lys Asp Met Ser Ser Leu His Ile Ser 
    370                 375                 380                 


Pro Asn Ser Asp Xaa Gly Leu Gly Asp Ser Val Cys Ser Ser Pro Ser 
385                 390                 395                 400 


Ile Ser Ser Xaa Xaa Ser Pro Lys Leu Asp Pro Pro Pro Ser Pro His 
                405                 410                 415     


Ala Asn Arg Lys Lys His Arg Arg Lys Lys Ser Xaa Ser Asn Phe Lys 
            420                 425                 430         


Ala Asp Gly Leu Ser Gly Xaa Ala Glu Glu Gln Glu Glu Asn Phe Glu 
        435                 440                 445             


Phe Ile Ile Val Ser Leu Xaa Gly Gln Xaa Trp His Phe Glu Ala Xaa 
    450                 455                 460                 


Xaa Tyr Glu Glu Arg Asp Ala Trp Val Gln Ala Ile Glu Ser Gln Ile 
465                 470                 475                 480 


Leu Ala Ser Leu Gln Ser Cys Glu Ser Ser Lys Asn Lys Ser Arg Leu 
                485                 490                 495     


Xaa Ser Gln Ser Glu Ala Met Ala Leu Gln Ser Ile Arg Asn Met Arg 
            500                 505                 510         


Gly Asn Ser His Cys Val Asp Cys Glu Xaa Gln Asn Pro Asn Trp Ala 
        515                 520                 525             


Ser Leu Asn Leu Gly Ala Leu Met Cys Ile Glu Cys Ser Gly Ile His 
    530                 535                 540                 


Arg Asn Leu Gly Xaa His Leu Ser Arg Val Arg Ser Leu Asp Leu Asp 
545                 550                 555                 560 


Asp Trp Pro Val Glu Leu Ile Lys Val Met Ser Ser Ile Gly Asn Glu 
                565                 570                 575     


Leu Ala Asn Ser Val Trp Glu Glu Ser Ser Gln Gly Arg Xaa Lys Pro 
            580                 585                 590         


Ser Val Asp Ser Xaa Arg Glu Glu Lys Glu Arg Trp Ile Arg Ala Lys 
        595                 600                 605             


Tyr Glu Gln Lys Leu Phe Leu Ala Pro Leu Pro Cys Xaa Glu Leu Ser 
    610                 615                 620                 


Leu Gly Gln His Leu Leu Arg Ala Xaa Ala Asp Glu Asp Leu Arg Xaa 
625                 630                 635                 640 


Ala Ile Leu Leu Leu Ala His Gly Ser Arg Asp Glu Val Asn Glu Xaa 
                645                 650                 655     


Cys Gly Glu Gly Asp Gly Arg Xaa Ala Leu His Leu Ala Cys Arg Lys 
            660                 665                 670         


Gly Asn Val Val Leu Ala Gln Leu Leu Ile Trp Tyr Gly Val Asp Val 
        675                 680                 685             


Xaa Ala Arg Asp Ala His Gly Asn Xaa Ala Leu Ala Tyr Ala Arg Gln 
    690                 695                 700                 


Ala Ser Ser Gln Glu Cys Ile Asp Val Leu Leu Gln Tyr Gly Cys Pro 
705                 710                 715                 720 


Asp Glu Arg Phe Val Leu Met Ala Xaa Pro Asn Leu Ser Arg Arg Asn 
                725                 730                 735     


Asn Asn Arg Asn Asn Ser Ser Gly Arg Val Pro Xaa Ile Ile 
            740                 745                 750 


<210> 1925
<211> 803
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<400> 1925
Asp Ala Phe Val Asn Ser Gln Glu Trp Xaa Leu Ser Arg Ser Val Pro 
1               5                   10                  15      


Glu Leu Lys Val Gly Ile Val Gly Asn Leu Ala Ser Gly Lys Ser Ala 
            20                  25                  30          


Leu Val His Arg Tyr Leu Xaa Gly Xaa Tyr Val Gln Glu Glu Ser Pro 
        35                  40                  45              


Glu Gly Gly Arg Phe Lys Lys Glu Ile Val Val Asp Gly Gln Ser Tyr 
    50                  55                  60                  


Leu Leu Leu Ile Arg Asp Glu Gly Gly Pro Pro Glu Ala Gln Phe Ala 
65                  70                  75                  80  


Met Trp Val Asp Ala Val Ile Phe Val Phe Ser Leu Glu Asp Glu Ile 
                85                  90                  95      


Ser Phe Gln Xaa Val Tyr His Tyr Tyr Ser Arg Met Ala Asn Tyr Arg 
            100                 105                 110         


Asn Xaa Ser Glu Ile Pro Leu Val Leu Val Gly Xaa Gln Asp Ala Ile 
        115                 120                 125             


Ser Ser Ala Asn Pro Arg Val Ile Asp Asp Ala Arg Ala Arg Lys Leu 
    130                 135                 140                 


Ser Asn Asp Leu Lys Arg Cys Xaa Tyr Tyr Glu Xaa Cys Ala Xaa Tyr 
145                 150                 155                 160 


Gly Leu Asn Val Glu Arg Val Phe Gln Asp Val Ala Gln Lys Ile Val 
                165                 170                 175     


Ala Xaa Arg Lys Lys Gln Gln Leu Ser Ile Gly Pro Cys Lys Ser Leu 
            180                 185                 190         


Pro Asn Ser Pro Ser His Ser Ser Val Cys Ser Ala Gln Val Ser Ala 
        195                 200                 205             


Val His Ile Ser Gln Xaa Ser Asn Gly Gly Gly Ser Leu Ser Asp Tyr 
    210                 215                 220                 


Ser Ser Ser Val Pro Ser Xaa Pro Ser Xaa Ser Gln Lys Glu Leu Arg 
225                 230                 235                 240 


Ile Asp Val Pro Pro Xaa Ala Asn Xaa Pro Xaa Pro Val Arg Lys Gln 
                245                 250                 255     


Ser Lys Arg Arg Ser Asn Leu Phe Xaa Ser Arg Lys Gly Ser Asp Pro 
            260                 265                 270         


Asp Lys Glu Lys Lys Gly Leu Glu Ser Arg Ala Asp Ser Ile Gly Ser 
        275                 280                 285             


Gly Arg Ala Ile Pro Ile Lys Gln Gly Met Leu Leu Lys Arg Ser Gly 
    290                 295                 300                 


Lys Ser Leu Asn Lys Glu Trp Lys Lys Lys Tyr Val Xaa Leu Cys Asp 
305                 310                 315                 320 


Asn Gly Val Leu Xaa Tyr His Pro Ser Leu His Asp Tyr Met Gln Asn 
                325                 330                 335     


Val His Gly Lys Glu Ile Asp Leu Leu Arg Xaa Xaa Val Lys Val Pro 
            340                 345                 350         


Gly Lys Arg Pro Pro Arg Ala Xaa Ser Ala Cys Ala Pro Ile Ser Ser 
        355                 360                 365             


Pro Lys Xaa Asn Gly Leu Ser Lys Asp Met Ser Ser Leu His Ile Ser 
    370                 375                 380                 


Pro Asn Ser Gly Asn Val Xaa Ser Ala Ser Gly Ser Gln Met Ala Ser 
385                 390                 395                 400 


Gly Ile Ser Leu Val Ser Phe Asn Ser Arg Pro Asp Gly Met His Gln 
                405                 410                 415     


Arg Ser Tyr Ser Val Ser Ser Ala Asp Gln Trp Ser Glu Ala Xaa Val 
            420                 425                 430         


Ile Ala Asn Ser Ala Ile Ser Ser Asp Xaa Gly Leu Gly Asp Ser Val 
        435                 440                 445             


Cys Ser Ser Pro Ser Ile Ser Ser Xaa Xaa Ser Pro Lys Leu Asp Pro 
    450                 455                 460                 


Pro Pro Ser Pro His Ala Asn Arg Lys Lys His Arg Arg Lys Lys Ser 
465                 470                 475                 480 


Xaa Ser Asn Phe Lys Ala Asp Gly Leu Ser Gly Xaa Ala Glu Glu Gln 
                485                 490                 495     


Glu Glu Asn Phe Glu Phe Ile Ile Val Ser Leu Xaa Gly Gln Xaa Trp 
            500                 505                 510         


His Phe Glu Ala Xaa Xaa Tyr Glu Glu Arg Asp Ala Trp Val Gln Ala 
        515                 520                 525             


Ile Glu Ser Gln Ile Leu Ala Ser Leu Gln Ser Cys Glu Ser Ser Lys 
    530                 535                 540                 


Asn Lys Ser Arg Leu Xaa Ser Gln Ser Glu Ala Met Ala Leu Gln Ser 
545                 550                 555                 560 


Ile Arg Asn Met Arg Gly Asn Ser His Cys Val Asp Cys Glu Xaa Gln 
                565                 570                 575     


Asn Pro Asn Trp Ala Ser Leu Asn Leu Gly Ala Leu Met Cys Ile Glu 
            580                 585                 590         


Cys Ser Gly Ile His Arg Asn Leu Gly Xaa His Leu Ser Arg Val Arg 
        595                 600                 605             


Ser Leu Asp Leu Asp Asp Trp Pro Val Glu Leu Ile Lys Val Met Ser 
    610                 615                 620                 


Ser Ile Gly Asn Glu Leu Ala Asn Ser Val Trp Glu Glu Ser Ser Gln 
625                 630                 635                 640 


Gly Arg Xaa Lys Pro Ser Val Asp Ser Xaa Arg Glu Glu Lys Glu Arg 
                645                 650                 655     


Trp Ile Arg Ala Lys Tyr Glu Gln Lys Leu Phe Leu Ala Pro Leu Pro 
            660                 665                 670         


Cys Xaa Glu Leu Ser Leu Gly Gln His Leu Leu Arg Ala Xaa Ala Asp 
        675                 680                 685             


Glu Asp Leu Arg Xaa Ala Ile Leu Leu Leu Ala His Gly Ser Arg Asp 
    690                 695                 700                 


Glu Val Asn Glu Xaa Cys Gly Glu Gly Asp Gly Arg Xaa Ala Leu His 
705                 710                 715                 720 


Leu Ala Cys Arg Lys Gly Asn Val Val Leu Ala Gln Leu Leu Ile Trp 
                725                 730                 735     


Tyr Gly Val Asp Val Xaa Ala Arg Asp Ala His Gly Asn Xaa Ala Leu 
            740                 745                 750         


Ala Tyr Ala Arg Gln Ala Ser Ser Gln Glu Cys Ile Asp Val Leu Leu 
        755                 760                 765             


Gln Tyr Gly Cys Pro Asp Glu Arg Phe Val Leu Met Ala Xaa Pro Asn 
    770                 775                 780                 


Leu Ser Arg Arg Asn Asn Asn Arg Asn Asn Ser Ser Gly Arg Val Pro 
785                 790                 795                 800 


Xaa Ile Ile 
            


<210> 1926
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 1926
Met Asp Ala Phe Val Asn Ser Gln Glu Trp Xaa Leu Ser Arg Ser Val 
1               5                   10                  15      


Pro Glu Leu Lys Val Gly Ile Val Gly Asn Leu Ala Ser Gly Lys Ser 
            20                  25                  30          


Ala Leu Val His Arg Tyr Leu Xaa Gly Xaa Tyr Val Gln Glu Glu Ser 
        35                  40                  45              


Pro Glu Gly Gly Arg Phe Lys Lys Glu Ile Val Val Asp Gly Gln Ser 
    50                  55                  60                  


Tyr Leu Leu Leu Ile Arg Asp Glu Gly Gly Pro Pro Glu Ala Gln Phe 
65                  70                  75                  80  


Ala Met Trp Val Asp Ala Val Ile Phe Val Phe Ser Leu Glu Asp Glu 
                85                  90                  95      


Ile Ser Phe Gln Xaa Val Tyr His Tyr Tyr Ser Arg Met Ala Asn Tyr 
            100                 105                 110         


Arg Asn Xaa Ser Glu 
        115         


<210> 1927
<211> 405
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<400> 1927
Met Asn Tyr Gln Gln Gln Leu Ala Asn Ser Ala Ala Ile Arg Ala Glu 
1               5                   10                  15      


Ile Gln Arg Phe Glu Ser Val His Pro Asn Ile Tyr Ser Ile Tyr Glu 
            20                  25                  30          


Leu Leu Glu Arg Val Glu Glu Pro Val Leu Gln Asn Gln Ile Arg Glu 
        35                  40                  45              


His Val Ile Ala Ile Glu Asp Ala Phe Val Asn Ser Gln Glu Trp Xaa 
    50                  55                  60                  


Leu Ser Arg Ser Val Pro Glu Leu Lys Val Gly Ile Val Gly Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Lys Ser Ala Leu Val His Arg Tyr Leu Xaa Gly Xaa Tyr 
                85                  90                  95      


Val Gln Glu Glu Ser Pro Glu Gly Gly Arg Phe Lys Lys Glu Ile Val 
            100                 105                 110         


Val Asp Gly Gln Ser Tyr Leu Leu Leu Ile Arg Asp Glu Gly Gly Pro 
        115                 120                 125             


Pro Glu Ala Gln Phe Ala Met Trp Val Asp Ala Val Ile Phe Val Phe 
    130                 135                 140                 


Ser Leu Glu Asp Glu Ile Ser Phe Gln Xaa Val Tyr His Tyr Tyr Ser 
145                 150                 155                 160 


Arg Met Ala Asn Tyr Arg Asn Xaa Ser Glu Ile Pro Leu Val Leu Val 
                165                 170                 175     


Gly Xaa Gln Asp Ala Ile Ser Ser Ala Asn Pro Arg Val Ile Asp Asp 
            180                 185                 190         


Ala Arg Ala Arg Lys Leu Ser Asn Asp Leu Lys Arg Cys Xaa Tyr Tyr 
        195                 200                 205             


Glu Xaa Cys Ala Xaa Tyr Gly Leu Asn Val Glu Arg Val Phe Gln Asp 
    210                 215                 220                 


Val Ala Gln Lys Ile Val Ala Xaa Arg Lys Lys Gln Gln Leu Ser Ile 
225                 230                 235                 240 


Gly Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser His Ser Ser Val Cys 
                245                 250                 255     


Ser Ala Gln Val Ser Ala Val His Ile Ser Gln Xaa Ser Asn Gly Gly 
            260                 265                 270         


Gly Ser Leu Ser Asp Tyr Ser Ser Ser Val Pro Ser Xaa Pro Ser Xaa 
        275                 280                 285             


Ser Gln Lys Glu Leu Arg Ile Asp Val Pro Pro Xaa Ala Asn Xaa Pro 
    290                 295                 300                 


Xaa Pro Val Arg Lys Gln Ser Lys Arg Arg Ser Asn Leu Phe Xaa Ser 
305                 310                 315                 320 


Arg Lys Gly Ser Asp Pro Asp Lys Glu Lys Lys Gly Leu Glu Ser Arg 
                325                 330                 335     


Ala Asp Ser Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys Gln Gly Leu 
            340                 345                 350         


Pro Phe Phe Val Leu Ala Leu Xaa Ala Ser Xaa Tyr Leu Arg Pro Ala 
        355                 360                 365             


Gly Ala Arg Ala Arg Gln Ser Ser Pro Trp Pro Gly Pro Arg Gly Gly 
    370                 375                 380                 


Gln Xaa Ser Pro His Cys Ala Glu Gly Pro Gln Ser Ala Gln Leu Ser 
385                 390                 395                 400 


Gly Ala Met Met Asn 
                405 


<210> 1928
<211> 804
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<400> 1928
Met Asn Tyr Gln Gln Gln Leu Ala Asn Ser Ala Ala Ile Arg Ala Glu 
1               5                   10                  15      


Ile Gln Arg Phe Glu Ser Val His Pro Asn Ile Tyr Ser Ile Tyr Glu 
            20                  25                  30          


Leu Leu Glu Arg Val Glu Glu Pro Val Leu Gln Asn Gln Ile Arg Glu 
        35                  40                  45              


His Val Ile Ala Ile Glu Asp Ala Phe Val Asn Ser Gln Glu Trp Xaa 
    50                  55                  60                  


Leu Ser Arg Ser Val Pro Glu Leu Lys Val Gly Ile Val Gly Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Lys Ser Ala Leu Val His Arg Tyr Leu Xaa Gly Xaa Tyr 
                85                  90                  95      


Val Gln Glu Glu Ser Pro Glu Gly Gly Arg Phe Lys Lys Glu Ile Val 
            100                 105                 110         


Val Asp Gly Gln Ser Tyr Leu Leu Leu Ile Arg Asp Glu Gly Gly Pro 
        115                 120                 125             


Pro Glu Ala Gln Phe Ala Met Trp Val Asp Ala Val Ile Phe Val Phe 
    130                 135                 140                 


Ser Leu Glu Asp Glu Ile Ser Phe Gln Xaa Val Tyr His Tyr Tyr Ser 
145                 150                 155                 160 


Arg Met Ala Asn Tyr Arg Asn Xaa Ser Glu Ile Pro Leu Val Leu Val 
                165                 170                 175     


Gly Xaa Gln Asp Ala Ile Ser Ser Ala Asn Pro Arg Val Ile Asp Asp 
            180                 185                 190         


Ala Arg Ala Arg Lys Leu Ser Asn Asp Leu Lys Arg Cys Xaa Tyr Tyr 
        195                 200                 205             


Glu Xaa Cys Ala Xaa Tyr Gly Leu Asn Val Glu Arg Val Phe Gln Asp 
    210                 215                 220                 


Val Ala Gln Lys Ile Val Ala Xaa Arg Lys Lys Gln Gln Leu Ser Ile 
225                 230                 235                 240 


Gly Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser His Ser Ser Val Cys 
                245                 250                 255     


Ser Ala Gln Val Ser Ala Val His Ile Ser Gln Xaa Ser Asn Gly Gly 
            260                 265                 270         


Gly Ser Leu Ser Asp Tyr Ser Ser Ser Val Pro Ser Xaa Pro Ser Xaa 
        275                 280                 285             


Ser Gln Lys Glu Leu Arg Ile Asp Val Pro Pro Xaa Ala Asn Xaa Pro 
    290                 295                 300                 


Xaa Pro Val Arg Lys Gln Ser Lys Arg Arg Ser Asn Leu Phe Xaa Ser 
305                 310                 315                 320 


Arg Lys Gly Ser Asp Pro Asp Lys Glu Lys Lys Gly Leu Glu Ser Arg 
                325                 330                 335     


Ala Asp Ser Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys Gln Gly Met 
            340                 345                 350         


Leu Leu Lys Arg Ser Gly Lys Ser Leu Asn Lys Glu Trp Lys Lys Lys 
        355                 360                 365             


Tyr Val Xaa Leu Cys Asp Asn Gly Val Leu Xaa Tyr His Pro Ser Leu 
    370                 375                 380                 


His Asp Tyr Met Gln Asn Val His Gly Lys Glu Ile Asp Leu Leu Arg 
385                 390                 395                 400 


Xaa Xaa Val Lys Val Pro Gly Lys Arg Pro Pro Arg Ala Xaa Ser Ala 
                405                 410                 415     


Cys Ala Pro Ile Ser Ser Pro Lys Xaa Asn Gly Leu Ser Lys Asp Met 
            420                 425                 430         


Ser Ser Leu His Ile Ser Pro Asn Ser Asp Xaa Gly Leu Gly Asp Ser 
        435                 440                 445             


Val Cys Ser Ser Pro Ser Ile Ser Ser Xaa Xaa Ser Pro Lys Leu Asp 
    450                 455                 460                 


Pro Pro Pro Ser Pro His Ala Asn Arg Lys Lys His Arg Arg Lys Lys 
465                 470                 475                 480 


Ser Xaa Ser Asn Phe Lys Ala Asp Gly Leu Ser Gly Xaa Ala Glu Glu 
                485                 490                 495     


Gln Glu Glu Asn Phe Glu Phe Ile Ile Val Ser Leu Xaa Gly Gln Xaa 
            500                 505                 510         


Trp His Phe Glu Ala Xaa Xaa Tyr Glu Glu Arg Asp Ala Trp Val Gln 
        515                 520                 525             


Ala Ile Glu Ser Gln Ile Leu Ala Ser Leu Gln Ser Cys Glu Ser Ser 
    530                 535                 540                 


Lys Asn Lys Ser Arg Leu Xaa Ser Gln Ser Glu Ala Met Ala Leu Gln 
545                 550                 555                 560 


Ser Ile Arg Asn Met Arg Gly Asn Ser His Cys Val Asp Cys Glu Xaa 
                565                 570                 575     


Gln Asn Pro Asn Trp Ala Ser Leu Asn Leu Gly Ala Leu Met Cys Ile 
            580                 585                 590         


Glu Cys Ser Gly Ile His Arg Asn Leu Gly Xaa His Leu Ser Arg Val 
        595                 600                 605             


Arg Ser Leu Asp Leu Asp Asp Trp Pro Val Glu Leu Ile Lys Val Met 
    610                 615                 620                 


Ser Ser Ile Gly Asn Glu Leu Ala Asn Ser Val Trp Glu Glu Ser Ser 
625                 630                 635                 640 


Gln Gly Arg Xaa Lys Pro Ser Val Asp Ser Xaa Arg Glu Glu Lys Glu 
                645                 650                 655     


Arg Trp Ile Arg Ala Lys Tyr Glu Gln Lys Leu Phe Leu Ala Pro Leu 
            660                 665                 670         


Pro Cys Xaa Glu Leu Ser Leu Gly Gln His Leu Leu Arg Ala Xaa Ala 
        675                 680                 685             


Asp Glu Asp Leu Arg Xaa Ala Ile Leu Leu Leu Ala His Gly Ser Arg 
    690                 695                 700                 


Asp Glu Val Asn Glu Xaa Cys Gly Glu Gly Asp Gly Arg Xaa Ala Leu 
705                 710                 715                 720 


His Leu Ala Cys Arg Lys Gly Asn Val Val Leu Ala Gln Leu Leu Ile 
                725                 730                 735     


Trp Tyr Gly Val Asp Val Xaa Ala Arg Asp Ala His Gly Asn Xaa Ala 
            740                 745                 750         


Leu Ala Tyr Ala Arg Gln Ala Ser Ser Gln Glu Cys Ile Asp Val Leu 
        755                 760                 765             


Leu Gln Tyr Gly Cys Pro Asp Glu Arg Phe Val Leu Met Ala Xaa Pro 
    770                 775                 780                 


Asn Leu Ser Arg Arg Asn Asn Asn Arg Asn Asn Ser Ser Gly Arg Val 
785                 790                 795                 800 


Pro Xaa Ile Ile 
                


<210> 1929
<211> 857
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<400> 1929
Met Asn Tyr Gln Gln Gln Leu Ala Asn Ser Ala Ala Ile Arg Ala Glu 
1               5                   10                  15      


Ile Gln Arg Phe Glu Ser Val His Pro Asn Ile Tyr Ser Ile Tyr Glu 
            20                  25                  30          


Leu Leu Glu Arg Val Glu Glu Pro Val Leu Gln Asn Gln Ile Arg Glu 
        35                  40                  45              


His Val Ile Ala Ile Glu Asp Ala Phe Val Asn Ser Gln Glu Trp Xaa 
    50                  55                  60                  


Leu Ser Arg Ser Val Pro Glu Leu Lys Val Gly Ile Val Gly Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Lys Ser Ala Leu Val His Arg Tyr Leu Xaa Gly Xaa Tyr 
                85                  90                  95      


Val Gln Glu Glu Ser Pro Glu Gly Gly Arg Phe Lys Lys Glu Ile Val 
            100                 105                 110         


Val Asp Gly Gln Ser Tyr Leu Leu Leu Ile Arg Asp Glu Gly Gly Pro 
        115                 120                 125             


Pro Glu Ala Gln Phe Ala Met Trp Val Asp Ala Val Ile Phe Val Phe 
    130                 135                 140                 


Ser Leu Glu Asp Glu Ile Ser Phe Gln Xaa Val Tyr His Tyr Tyr Ser 
145                 150                 155                 160 


Arg Met Ala Asn Tyr Arg Asn Xaa Ser Glu Ile Pro Leu Val Leu Val 
                165                 170                 175     


Gly Xaa Gln Asp Ala Ile Ser Ser Ala Asn Pro Arg Val Ile Asp Asp 
            180                 185                 190         


Ala Arg Ala Arg Lys Leu Ser Asn Asp Leu Lys Arg Cys Xaa Tyr Tyr 
        195                 200                 205             


Glu Xaa Cys Ala Xaa Tyr Gly Leu Asn Val Glu Arg Val Phe Gln Asp 
    210                 215                 220                 


Val Ala Gln Lys Ile Val Ala Xaa Arg Lys Lys Gln Gln Leu Ser Ile 
225                 230                 235                 240 


Gly Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser His Ser Ser Val Cys 
                245                 250                 255     


Ser Ala Gln Val Ser Ala Val His Ile Ser Gln Xaa Ser Asn Gly Gly 
            260                 265                 270         


Gly Ser Leu Ser Asp Tyr Ser Ser Ser Val Pro Ser Xaa Pro Ser Xaa 
        275                 280                 285             


Ser Gln Lys Glu Leu Arg Ile Asp Val Pro Pro Xaa Ala Asn Xaa Pro 
    290                 295                 300                 


Xaa Pro Val Arg Lys Gln Ser Lys Arg Arg Ser Asn Leu Phe Xaa Ser 
305                 310                 315                 320 


Arg Lys Gly Ser Asp Pro Asp Lys Glu Lys Lys Gly Leu Glu Ser Arg 
                325                 330                 335     


Ala Asp Ser Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys Gln Gly Met 
            340                 345                 350         


Leu Leu Lys Arg Ser Gly Lys Ser Leu Asn Lys Glu Trp Lys Lys Lys 
        355                 360                 365             


Tyr Val Xaa Leu Cys Asp Asn Gly Val Leu Xaa Tyr His Pro Ser Leu 
    370                 375                 380                 


His Asp Tyr Met Gln Asn Val His Gly Lys Glu Ile Asp Leu Leu Arg 
385                 390                 395                 400 


Xaa Xaa Val Lys Val Pro Gly Lys Arg Pro Pro Arg Ala Xaa Ser Ala 
                405                 410                 415     


Cys Ala Pro Ile Ser Ser Pro Lys Xaa Asn Gly Leu Ser Lys Asp Met 
            420                 425                 430         


Ser Ser Leu His Ile Ser Pro Asn Ser Gly Asn Val Xaa Ser Ala Ser 
        435                 440                 445             


Gly Ser Gln Met Ala Ser Gly Ile Ser Leu Val Ser Phe Asn Ser Arg 
    450                 455                 460                 


Pro Asp Gly Met His Gln Arg Ser Tyr Ser Val Ser Ser Ala Asp Gln 
465                 470                 475                 480 


Trp Ser Glu Ala Xaa Val Ile Ala Asn Ser Ala Ile Ser Ser Asp Xaa 
                485                 490                 495     


Gly Leu Gly Asp Ser Val Cys Ser Ser Pro Ser Ile Ser Ser Xaa Xaa 
            500                 505                 510         


Ser Pro Lys Leu Asp Pro Pro Pro Ser Pro His Ala Asn Arg Lys Lys 
        515                 520                 525             


His Arg Arg Lys Lys Ser Xaa Ser Asn Phe Lys Ala Asp Gly Leu Ser 
    530                 535                 540                 


Gly Xaa Ala Glu Glu Gln Glu Glu Asn Phe Glu Phe Ile Ile Val Ser 
545                 550                 555                 560 


Leu Xaa Gly Gln Xaa Trp His Phe Glu Ala Xaa Xaa Tyr Glu Glu Arg 
                565                 570                 575     


Asp Ala Trp Val Gln Ala Ile Glu Ser Gln Ile Leu Ala Ser Leu Gln 
            580                 585                 590         


Ser Cys Glu Ser Ser Lys Asn Lys Ser Arg Leu Xaa Ser Gln Ser Glu 
        595                 600                 605             


Ala Met Ala Leu Gln Ser Ile Arg Asn Met Arg Gly Asn Ser His Cys 
    610                 615                 620                 


Val Asp Cys Glu Xaa Gln Asn Pro Asn Trp Ala Ser Leu Asn Leu Gly 
625                 630                 635                 640 


Ala Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg Asn Leu Gly Xaa 
                645                 650                 655     


His Leu Ser Arg Val Arg Ser Leu Asp Leu Asp Asp Trp Pro Val Glu 
            660                 665                 670         


Leu Ile Lys Val Met Ser Ser Ile Gly Asn Glu Leu Ala Asn Ser Val 
        675                 680                 685             


Trp Glu Glu Ser Ser Gln Gly Arg Xaa Lys Pro Ser Val Asp Ser Xaa 
    690                 695                 700                 


Arg Glu Glu Lys Glu Arg Trp Ile Arg Ala Lys Tyr Glu Gln Lys Leu 
705                 710                 715                 720 


Phe Leu Ala Pro Leu Pro Cys Xaa Glu Leu Ser Leu Gly Gln His Leu 
                725                 730                 735     


Leu Arg Ala Xaa Ala Asp Glu Asp Leu Arg Xaa Ala Ile Leu Leu Leu 
            740                 745                 750         


Ala His Gly Ser Arg Asp Glu Val Asn Glu Xaa Cys Gly Glu Gly Asp 
        755                 760                 765             


Gly Arg Xaa Ala Leu His Leu Ala Cys Arg Lys Gly Asn Val Val Leu 
    770                 775                 780                 


Ala Gln Leu Leu Ile Trp Tyr Gly Val Asp Val Xaa Ala Arg Asp Ala 
785                 790                 795                 800 


His Gly Asn Xaa Ala Leu Ala Tyr Ala Arg Gln Ala Ser Ser Gln Glu 
                805                 810                 815     


Cys Ile Asp Val Leu Leu Gln Tyr Gly Cys Pro Asp Glu Arg Phe Val 
            820                 825                 830         


Leu Met Ala Xaa Pro Asn Leu Ser Arg Arg Asn Asn Asn Arg Asn Asn 
        835                 840                 845             


Ser Ser Gly Arg Val Pro Xaa Ile Ile 
    850                 855         


<210> 1930
<211> 1069
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (983)..(983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<400> 1930
Met Tyr Leu Leu Asp Gly Ser Gly Glu Pro Ala Ser Pro Pro Ala Asp 
1               5                   10                  15      


Ala Met Pro Arg Gly Xaa Pro Pro Arg Lys Xaa Val Tyr Arg Ile Ser 
            20                  25                  30          


Val Xaa Met Val Arg Lys Glu Gln Leu Ala Ala Pro Gly Ser Gly Gly 
        35                  40                  45              


Pro Asp Pro Arg Pro Val Arg Arg Pro Arg Pro Ala Arg Ser Pro Asp 
    50                  55                  60                  


Ala Pro Gly Arg Leu Glu Glu Glu Ala Glu Glu Ala Glu Gly Ala Glu 
65                  70                  75                  80  


Glu Pro Glu Gly Pro Arg Pro Arg Ala Trp Asp Phe Arg Xaa Phe Arg 
                85                  90                  95      


Xaa Arg Ser Xaa Gly Gln Leu Glu Leu Gly Arg Leu Arg Pro Cys Ala 
            100                 105                 110         


Arg Gly Leu Glu Pro Ala Asp Leu Ala Gly Ser Ala Pro Ala Glu Glu 
        115                 120                 125             


Glu Gly Arg Gly Ser Pro Ala Ser Gly Ser Pro Asp Val Glu Gly Ala 
    130                 135                 140                 


Arg Ala Ala Pro Leu Arg Arg Ser Leu Ser Phe Arg His Trp Ser Gly 
145                 150                 155                 160 


Pro Glu Ala Pro Gln Gly Arg Xaa Leu Gly Gly Gly Arg Arg His Ser 
                165                 170                 175     


Ser Ser Gly Ser Leu Ala Trp Ala Pro Cys Asp Glu Ala Ala Ala Gly 
            180                 185                 190         


Xaa Xaa Leu Glu Pro Ala Xaa Ala Xaa Gln Pro Ala Ser Glu Lys Arg 
        195                 200                 205             


Asn Xaa Leu Asp Val Gly Glu Val Leu Ser Lys Asn Asp Ala Leu Ser 
    210                 215                 220                 


Asp Leu Glu Arg Trp Glu Arg Ser Lys Ser Lys Asn Arg Xaa Leu Asp 
225                 230                 235                 240 


Asn Ser Asp Leu Gln Arg Leu Glu Arg Ala Arg Ala Ala Ala Gly Ala 
                245                 250                 255     


Gly Ala Ala Ser Glu His Arg Leu Leu Arg Phe Phe Ser Gly Ile Phe 
            260                 265                 270         


Ala Arg Arg Asp Gly Gly Pro Gly Gly Gly Pro Ser Pro Arg Ser Gly 
        275                 280                 285             


Ala Ser Arg Pro Arg Gly Tyr Phe Ser Leu Arg Arg Ala Pro Ala Glu 
    290                 295                 300                 


Ala His Ser Ser Ser Ala Glu Ser Ile Asp Gly Ser Pro Arg Arg Asp 
305                 310                 315                 320 


Ala Phe Val Asn Ser Gln Glu Trp Xaa Leu Ser Arg Ser Val Pro Glu 
                325                 330                 335     


Leu Lys Val Gly Ile Val Gly Asn Leu Ala Ser Gly Lys Ser Ala Leu 
            340                 345                 350         


Val His Arg Tyr Leu Xaa Gly Xaa Tyr Val Gln Glu Glu Ser Pro Glu 
        355                 360                 365             


Gly Gly Arg Phe Lys Lys Glu Ile Val Val Asp Gly Gln Ser Tyr Leu 
    370                 375                 380                 


Leu Leu Ile Arg Asp Glu Gly Gly Pro Pro Glu Ala Gln Phe Ala Met 
385                 390                 395                 400 


Trp Val Asp Ala Val Ile Phe Val Phe Ser Leu Glu Asp Glu Ile Ser 
                405                 410                 415     


Phe Gln Xaa Val Tyr His Tyr Tyr Ser Arg Met Ala Asn Tyr Arg Asn 
            420                 425                 430         


Xaa Ser Glu Ile Pro Leu Val Leu Val Gly Xaa Gln Asp Ala Ile Ser 
        435                 440                 445             


Ser Ala Asn Pro Arg Val Ile Asp Asp Ala Arg Ala Arg Lys Leu Ser 
    450                 455                 460                 


Asn Asp Leu Lys Arg Cys Xaa Tyr Tyr Glu Xaa Cys Ala Xaa Tyr Gly 
465                 470                 475                 480 


Leu Asn Val Glu Arg Val Phe Gln Asp Val Ala Gln Lys Ile Val Ala 
                485                 490                 495     


Xaa Arg Lys Lys Gln Gln Leu Ser Ile Gly Pro Cys Lys Ser Leu Pro 
            500                 505                 510         


Asn Ser Pro Ser His Ser Ser Val Cys Ser Ala Gln Val Ser Ala Val 
        515                 520                 525             


His Ile Ser Gln Xaa Ser Asn Gly Gly Gly Ser Leu Ser Asp Tyr Ser 
    530                 535                 540                 


Ser Ser Val Pro Ser Xaa Pro Ser Xaa Ser Gln Lys Glu Leu Arg Ile 
545                 550                 555                 560 


Asp Val Pro Pro Xaa Ala Asn Xaa Pro Xaa Pro Val Arg Lys Gln Ser 
                565                 570                 575     


Lys Arg Arg Ser Asn Leu Phe Xaa Ser Arg Lys Gly Ser Asp Pro Asp 
            580                 585                 590         


Lys Glu Lys Lys Gly Leu Glu Ser Arg Ala Asp Ser Ile Gly Ser Gly 
        595                 600                 605             


Arg Ala Ile Pro Ile Lys Gln Gly Met Leu Leu Lys Arg Ser Gly Lys 
    610                 615                 620                 


Ser Leu Asn Lys Glu Trp Lys Lys Lys Tyr Val Xaa Leu Cys Asp Asn 
625                 630                 635                 640 


Gly Val Leu Xaa Tyr His Pro Ser Leu His Asp Tyr Met Gln Asn Val 
                645                 650                 655     


His Gly Lys Glu Ile Asp Leu Leu Arg Xaa Xaa Val Lys Val Pro Gly 
            660                 665                 670         


Lys Arg Pro Pro Arg Ala Xaa Ser Ala Cys Ala Pro Ile Ser Ser Pro 
        675                 680                 685             


Lys Xaa Asn Gly Leu Ser Lys Asp Met Ser Ser Leu His Ile Ser Pro 
    690                 695                 700                 


Asn Ser Asp Xaa Gly Leu Gly Asp Ser Val Cys Ser Ser Pro Ser Ile 
705                 710                 715                 720 


Ser Ser Xaa Xaa Ser Pro Lys Leu Asp Pro Pro Pro Ser Pro His Ala 
                725                 730                 735     


Asn Arg Lys Lys His Arg Arg Lys Lys Ser Xaa Ser Asn Phe Lys Ala 
            740                 745                 750         


Asp Gly Leu Ser Gly Xaa Ala Glu Glu Gln Glu Glu Asn Phe Glu Phe 
        755                 760                 765             


Ile Ile Val Ser Leu Xaa Gly Gln Xaa Trp His Phe Glu Ala Xaa Xaa 
    770                 775                 780                 


Tyr Glu Glu Arg Asp Ala Trp Val Gln Ala Ile Glu Ser Gln Ile Leu 
785                 790                 795                 800 


Ala Ser Leu Gln Ser Cys Glu Ser Ser Lys Asn Lys Ser Arg Leu Xaa 
                805                 810                 815     


Ser Gln Ser Glu Ala Met Ala Leu Gln Ser Ile Arg Asn Met Arg Gly 
            820                 825                 830         


Asn Ser His Cys Val Asp Cys Glu Xaa Gln Asn Pro Asn Trp Ala Ser 
        835                 840                 845             


Leu Asn Leu Gly Ala Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg 
    850                 855                 860                 


Asn Leu Gly Xaa His Leu Ser Arg Val Arg Ser Leu Asp Leu Asp Asp 
865                 870                 875                 880 


Trp Pro Val Glu Leu Ile Lys Val Met Ser Ser Ile Gly Asn Glu Leu 
                885                 890                 895     


Ala Asn Ser Val Trp Glu Glu Ser Ser Gln Gly Arg Xaa Lys Pro Ser 
            900                 905                 910         


Val Asp Ser Xaa Arg Glu Glu Lys Glu Arg Trp Ile Arg Ala Lys Tyr 
        915                 920                 925             


Glu Gln Lys Leu Phe Leu Ala Pro Leu Pro Cys Xaa Glu Leu Ser Leu 
    930                 935                 940                 


Gly Gln His Leu Leu Arg Ala Xaa Ala Asp Glu Asp Leu Arg Xaa Ala 
945                 950                 955                 960 


Ile Leu Leu Leu Ala His Gly Ser Arg Asp Glu Val Asn Glu Xaa Cys 
                965                 970                 975     


Gly Glu Gly Asp Gly Arg Xaa Ala Leu His Leu Ala Cys Arg Lys Gly 
            980                 985                 990         


Asn Val Val Leu Ala Gln Leu Leu  Ile Trp Tyr Gly Val  Asp Val Xaa 
        995                 1000                 1005             


Ala Arg  Asp Ala His Gly Asn  Xaa Ala Leu Ala Tyr  Ala Arg Gln 
    1010                 1015                 1020             


Ala Ser  Ser Gln Glu Cys Ile  Asp Val Leu Leu Gln  Tyr Gly Cys 
    1025                 1030                 1035             


Pro Asp  Glu Arg Phe Val Leu  Met Ala Xaa Pro Asn  Leu Ser Arg 
    1040                 1045                 1050             


Arg Asn  Asn Asn Arg Asn Asn  Ser Ser Gly Arg Val  Pro Xaa Ile 
    1055                 1060                 1065             


Ile 
    


<210> 1931
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<400> 1931
Gln Leu Ala Asn Ser Ala Ala Ile Arg Ala Glu Ile Gln Arg Phe Glu 
1               5                   10                  15      


Ser Val His Pro Asn Ile Tyr Ser Ile Tyr Glu Leu Leu Glu Arg Val 
            20                  25                  30          


Glu Glu Pro Val Leu Gln Asn Gln Ile Arg Glu His Val Ile Ala Ile 
        35                  40                  45              


Glu Asp Ala Phe Val Asn Ser Gln Glu Trp Xaa Leu Ser Arg Ser Val 
    50                  55                  60                  


Pro Glu Leu Lys Val Gly Ile Val Gly Asn Leu Ala Ser Gly Lys Ser 
65                  70                  75                  80  


Ala Leu Val His Arg Tyr Leu Xaa Gly Xaa Tyr Val Gln Glu Glu Tyr 
                85                  90                  95      


Gly Cys Arg Trp Gln Val Gln Glu Arg Asp Cys Arg 
            100                 105             


<210> 1932
<211> 253
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<400> 1932
Xaa Lys Tyr Val Xaa Leu Cys Asp Asn Gly Val Leu Xaa Tyr His Pro 
1               5                   10                  15      


Ser Leu His Asp Tyr Met Gln Asn Val His Gly Lys Glu Ile Asp Leu 
            20                  25                  30          


Leu Arg Xaa Xaa Val Lys Val Pro Gly Lys Arg Pro Pro Arg Ala Xaa 
        35                  40                  45              


Ser Ala Cys Ala Pro Ile Ser Ser Pro Lys Xaa Asn Gly Leu Ser Lys 
    50                  55                  60                  


Asp Met Ser Ser Leu His Ile Ser Pro Asn Ser Gly Asn Val Xaa Ser 
65                  70                  75                  80  


Ala Ser Gly Ser Gln Met Ala Ser Gly Ile Ser Leu Val Ser Phe Asn 
                85                  90                  95      


Ser Arg Pro Asp Gly Met His Gln Arg Ser Tyr Ser Val Ser Ser Ala 
            100                 105                 110         


Asp Gln Trp Ser Glu Ala Xaa Val Ile Ala Asn Ser Ala Ile Ser Ser 
        115                 120                 125             


Asp Xaa Gly Leu Gly Asp Ser Val Cys Ser Ser Pro Ser Ile Ser Ser 
    130                 135                 140                 


Xaa Xaa Ser Pro Lys Leu Asp Pro Pro Pro Ser Pro His Ala Asn Arg 
145                 150                 155                 160 


Lys Lys His Arg Arg Lys Lys Ser Xaa Ser Asn Phe Lys Ala Asp Gly 
                165                 170                 175     


Leu Ser Gly Xaa Ala Glu Ala Lys Arg Lys Ala Trp Lys Leu Asn Arg 
            180                 185                 190         


Val Gly Ser Leu Arg Asn Ile Tyr Ser Ser Ser Xaa Asn Xaa Glu Glu 
        195                 200                 205             


Gln Glu Glu Asn Phe Glu Phe Ile Ile Val Ser Leu Xaa Gly Gln Xaa 
    210                 215                 220                 


Trp His Phe Glu Ala Xaa Xaa Tyr Glu Glu Arg Asp Ala Trp Val Gln 
225                 230                 235                 240 


Ala Ile Glu Ser Gln Ile Leu Ala Ser Leu Gln Ser Cys 
                245                 250             


<210> 1933
<211> 276
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<400> 1933
Xaa Ser Ser Pro Lys Xaa Asn Gly Leu Ser Lys Asp Met Ser Ser Leu 
1               5                   10                  15      


His Ile Ser Pro Asn Ser Asp Xaa Gly Leu Gly Asp Ser Val Cys Ser 
            20                  25                  30          


Ser Pro Ser Ile Ser Ser Xaa Xaa Ser Pro Lys Leu Asp Pro Pro Pro 
        35                  40                  45              


Ser Pro His Ala Asn Arg Lys Lys His Arg Arg Lys Lys Ser Xaa Ser 
    50                  55                  60                  


Asn Phe Lys Ala Asp Gly Leu Ser Gly Xaa Ala Glu Ala Lys Arg Lys 
65                  70                  75                  80  


Ala Trp Lys Leu Asn Arg Val Gly Ser Leu Arg Asn Ile Tyr Ser Ser 
                85                  90                  95      


Ser Xaa Asn Xaa Glu Glu Gln Glu Glu Asn Phe Glu Phe Ile Ile Val 
            100                 105                 110         


Ser Leu Xaa Gly Gln Xaa Trp His Phe Glu Ala Xaa Xaa Tyr Glu Glu 
        115                 120                 125             


Arg Asp Ala Trp Val Gln Ala Ile Glu Ser Gln Ile Leu Ala Ser Leu 
    130                 135                 140                 


Gln Ser Cys Glu Ser Ser Lys Asn Lys Ser Arg Leu Xaa Ser Gln Ser 
145                 150                 155                 160 


Glu Ala Met Ala Leu Gln Ser Ile Arg Asn Met Arg Gly Asn Ser His 
                165                 170                 175     


Cys Val Asp Cys Glu Xaa Gln Asn Pro Asn Trp Ala Ser Leu Asn Leu 
            180                 185                 190         


Gly Ala Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg Asn Leu Gly 
        195                 200                 205             


Xaa His Leu Ser Arg Val Arg Ser Leu Asp Leu Asp Asp Trp Pro Val 
    210                 215                 220                 


Glu Leu Ile Lys Val Met Ser Ser Ile Gly Asn Glu Leu Ala Asn Ser 
225                 230                 235                 240 


Val Trp Glu Glu Ser Ser Gln Gly Arg Xaa Lys Pro Ser Val Asp Ser 
                245                 250                 255     


Xaa Arg Glu Glu Lys Glu Arg Trp Ile Arg Ala Lys Tyr Glu Gln Lys 
            260                 265                 270         


Leu Phe Leu Ala 
        275     


<210> 1934
<211> 836
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<400> 1934
Met His Ala Gln Arg Gln Phe Val Val Ala Ala Val Arg Ala Glu Val 
1               5                   10                  15      


Arg Arg His Glu Val Ala Lys Gln Ala Leu Asn Arg Leu Arg Lys Leu 
            20                  25                  30          


Ala Glu Arg Val Asp Asp Pro Glu Leu Gln Asp Ser Ile Gln Ala Ser 
        35                  40                  45              


Leu Asp Ser Ile Arg Glu Ala Val Ile Asn Ser Gln Glu Trp Xaa Leu 
    50                  55                  60                  


Ser Arg Ser Ile Pro Glu Leu Arg Leu Gly Val Leu Gly Asp Ala Arg 
65                  70                  75                  80  


Ser Gly Lys Ser Ser Leu Ile His Arg Phe Leu Xaa Gly Ser Tyr Gln 
                85                  90                  95      


Val Leu Glu Lys Xaa Glu Ser Glu Gln Tyr Lys Lys Glu Met Leu Val 
            100                 105                 110         


Asp Gly Gln Xaa His Leu Val Leu Ile Arg Glu Glu Ala Gly Ala Pro 
        115                 120                 125             


Asp Ala Lys Phe Ser Gly Trp Ala Asp Ala Val Ile Phe Val Phe Ser 
    130                 135                 140                 


Leu Glu Asp Glu Asn Ser Phe Gln Ala Val Ser Arg Leu His Gly Gln 
145                 150                 155                 160 


Leu Ser Ser Leu Arg Gly Glu Gly Arg Gly Gly Leu Ala Leu Ala Leu 
                165                 170                 175     


Val Gly Xaa Gln Asp Arg Ile Ser Ala Ser Ser Pro Arg Val Val Gly 
            180                 185                 190         


Asp Ala Arg Ala Arg Ala Leu Cys Ala Asp Met Lys Arg Cys Ser Tyr 
        195                 200                 205             


Tyr Glu Xaa Cys Ala Xaa Tyr Gly Leu Asn Val Asp Arg Val Phe Gln 
    210                 215                 220                 


Glu Val Ala Gln Lys Val Val Xaa Leu Arg Lys Gln Gln Gln Leu Leu 
225                 230                 235                 240 


Ala Ala Cys Lys Ser Leu Pro Ser Ser Pro Ser His Ser Ala Ala Ser 
                245                 250                 255     


Xaa Pro Val Ala Gly Gln Ala Ser Asn Gly Gly His Xaa Ser Asp Tyr 
            260                 265                 270         


Ser Ser Ser Leu Pro Ser Ser Pro Asn Val Gly His Arg Glu Leu Arg 
        275                 280                 285             


Ala Glu Ala Ala Ala Val Ala Gly Leu Ser Xaa Pro Gly Ser Leu His 
    290                 295                 300                 


Arg Ala Ala Lys Arg Arg Xaa Ser Leu Phe Ala Asn Arg Arg Gly Ser 
305                 310                 315                 320 


Asp Ser Glu Lys Arg Ser Leu Asp Ser Arg Gly Glu Xaa Xaa Gly Ser 
                325                 330                 335     


Gly Arg Ala Ile Pro Ile Lys Gln Ser Phe Leu Leu Lys Arg Ser Gly 
            340                 345                 350         


Asn Ser Leu Asn Lys Glu Trp Lys Lys Lys Tyr Val Xaa Leu Ser Ser 
        355                 360                 365             


Asn Gly Phe Leu Leu Tyr His Pro Ser Ile Asn Asp Tyr Ile His Ser 
    370                 375                 380                 


Xaa His Gly Lys Glu Met Asp Leu Leu Arg Xaa Xaa Val Lys Val Pro 
385                 390                 395                 400 


Gly Lys Arg Pro Pro Arg Ala Ile Ser Ala Phe Gly Pro Ser Ala Ser 
                405                 410                 415     


Ile Asn Gly Leu Val Lys Asp Met Ser Xaa Val Gln Met Gly Glu Gly 
            420                 425                 430         


Leu Glu Ala Xaa Xaa Pro Met Pro Ser Pro Ser Pro Ser Pro Ser Ser 
        435                 440                 445             


Leu Gln Pro Pro Pro Asp Gln Xaa Ser Lys His Leu Leu Lys Pro Asp 
    450                 455                 460                 


Arg Asn Leu Ala Arg Ala Leu Ser Xaa Asp Cys Xaa Pro Ser Gly Asp 
465                 470                 475                 480 


Leu Ser Pro Leu Ser Arg Glu Pro Pro Pro Ser Pro Met Val Lys Lys 
                485                 490                 495     


Gln Arg Arg Lys Lys Leu Xaa Xaa Pro Ser Lys Xaa Glu Gly Ser Ala 
            500                 505                 510         


Gly Gln Ala Glu Glu Glu Asn Phe Glu Phe Leu Ile Val Ser Ser Xaa 
        515                 520                 525             


Gly Gln Xaa Trp His Phe Glu Ala Ala Ser Phe Glu Glu Arg Asp Ala 
    530                 535                 540                 


Trp Val Gln Ala Ile Glu Ser Gln Ile Leu Ala Ser Leu Gln Cys Cys 
545                 550                 555                 560 


Glu Ser Ser Lys Val Lys Leu Arg Xaa Asp Ser Gln Ser Glu Ala Val 
                565                 570                 575     


Ala Ile Gln Ala Ile Arg Asn Ala Lys Gly Asn Ser Ile Cys Val Asp 
            580                 585                 590         


Cys Gly Ala Pro Asn Pro Xaa Trp Ala Ser Leu Asn Leu Gly Ala Leu 
        595                 600                 605             


Ile Cys Ile Glu Cys Ser Gly Ile His Arg Asn Leu Gly Xaa His Leu 
    610                 615                 620                 


Ser Arg Val Arg Ser Leu Asp Leu Asp Asp Trp Pro Arg Glu Leu Xaa 
625                 630                 635                 640 


Leu Val Leu Xaa Ala Ile Gly Asn Asp Xaa Ala Asn Arg Val Trp Glu 
                645                 650                 655     


Ser Asp Xaa Arg Gly Arg Ala Lys Pro Ser Arg Asp Ser Ser Arg Glu 
            660                 665                 670         


Glu Arg Glu Ser Trp Ile Arg Ala Lys Tyr Glu Gln Leu Leu Phe Leu 
        675                 680                 685             


Ala Pro Leu Ser Xaa Ser Glu Glu Pro Leu Gly Arg Gln Leu Trp Ala 
    690                 695                 700                 


Ala Val Gln Ala Gln Asp Val Ala Xaa Val Leu Leu Leu Leu Ala His 
705                 710                 715                 720 


Ala Arg His Gly Pro Leu Asp Xaa Ser Val Glu Asp Pro Gln Leu Arg 
                725                 730                 735     


Ser Pro Leu His Leu Ala Ala Glu Leu Ala His Val Val Ile Xaa Gln 
            740                 745                 750         


Leu Leu Leu Trp Tyr Gly Ala Asp Val Ala Ala Arg Asp Ala Gln Gly 
        755                 760                 765             


Arg Xaa Ala Leu Phe Tyr Ala Arg Gln Ala Gly Ser Gln Leu Cys Ala 
    770                 775                 780                 


Asp Ile Leu Leu Gln His Gly Cys Pro Gly Glu Gly Gly Ser Ala Ala 
785                 790                 795                 800 


Xaa Xaa Pro Ser Ala Ala Xaa Xaa Pro Ser Ile Xaa Ala Xaa Pro Ser 
                805                 810                 815     


Pro Arg Arg Arg Ser Ser Ala Ala Ser Val Gly Arg Ala Asp Ala Pro 
            820                 825                 830         


Val Ala Leu Val 
        835     


<210> 1935
<211> 1192
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (996)..(996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1107)..(1107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<400> 1935
Met Ser Arg Gly Ala Gly Ala Leu Gln Arg Arg Xaa Xaa Xaa Tyr Leu 
1               5                   10                  15      


Ile Ser Leu Xaa Leu Val Lys Leu Glu Ser Val Pro Pro Pro Pro Pro 
            20                  25                  30          


Ser Pro Ser Ala Ala Ala Ala Gly Ala Ala Gly Ala Arg Gly Ser Glu 
        35                  40                  45              


Xaa Gly Asp Pro Gly Ser Pro Arg Gly Ala Glu Glu Pro Gly Lys Lys 
    50                  55                  60                  


Arg His Glu Arg Leu Phe His Arg Gln Asp Ala Leu Trp Ile Ser Xaa 
65                  70                  75                  80  


Ser Ser Ala Gly Xaa Gly Gly Ala Glu Pro Pro Ala Leu Ser Pro Ala 
                85                  90                  95      


Pro Ala Ser Pro Ala Arg Pro Val Ser Pro Ala Pro Gly Arg Arg Leu 
            100                 105                 110         


Ser Leu Trp Ala Val Pro Pro Gly Pro Pro Leu Ser Gly Gly Leu Ser 
        115                 120                 125             


Pro Asp Pro Lys Pro Gly Gly Ala Pro Xaa Ser Ser Arg Arg Pro Leu 
    130                 135                 140                 


Leu Ser Ser Pro Ser Trp Gly Gly Pro Glu Pro Glu Gly Arg Ala Gly 
145                 150                 155                 160 


Gly Gly Ile Pro Gly Ser Ser Ser Pro His Pro Gly Xaa Gly Ser Arg 
                165                 170                 175     


Arg Leu Lys Val Ala Pro Pro Pro Pro Ala Pro Lys Pro Cys Lys Xaa 
            180                 185                 190         


Val Xaa Xaa Ser Gly Ala Lys Ala Gly Gly Gly Lys Gly Ala Gly Ser 
        195                 200                 205             


Arg Leu Ser Trp Pro Glu Ser Glu Gly Lys Pro Arg Val Lys Gly Ser 
    210                 215                 220                 


Lys Ser Ser Ala Gly Xaa Gly Ala Ser Val Ser Ala Ala Ala Xaa Ala 
225                 230                 235                 240 


Ala Ala Ala Gly Gly Gly Gly Ser Xaa Ala Ser Xaa Ser Gly Gly Val 
                245                 250                 255     


Gly Ala Gly Ala Gly Ala Arg Gly Lys Leu Ser Pro Arg Lys Gly Lys 
            260                 265                 270         


Ser Lys Xaa Leu Asp Asn Ser Asp Leu His Pro Gly Pro Pro Ala Gly 
        275                 280                 285             


Ser Pro Pro Pro Leu Xaa Leu Pro Pro Xaa Pro Ser Pro Ala Xaa Ala 
    290                 295                 300                 


Val Xaa Ala Ala Ser Ala Gln Pro Pro Gly Pro Ala Pro Pro Ile Xaa 
305                 310                 315                 320 


Leu Glu Pro Pro Ala Pro Gly Leu Lys Arg Gly Arg Glu Gly Gly Arg 
                325                 330                 335     


Ala Ser Xaa Arg Asp Arg Lys Met Leu Lys Phe Ile Ser Gly Ile Phe 
            340                 345                 350         


Xaa Lys Ser Xaa Gly Gly Pro Pro Gly Ser Gly Pro Leu Pro Gly Pro 
        355                 360                 365             


Pro Ser Leu Ser Ser Gly Ser Gly Ser Arg Glu Leu Leu Gly Ala Glu 
    370                 375                 380                 


Leu Arg Ala Ser Pro Lys Ala Val Ile Asn Ser Gln Glu Trp Xaa Leu 
385                 390                 395                 400 


Ser Arg Ser Ile Pro Glu Leu Arg Leu Gly Val Leu Gly Asp Ala Arg 
                405                 410                 415     


Ser Gly Lys Ser Ser Leu Ile His Arg Phe Leu Xaa Gly Ser Tyr Gln 
            420                 425                 430         


Val Leu Glu Lys Xaa Glu Ser Glu Gln Tyr Lys Lys Glu Met Leu Val 
        435                 440                 445             


Asp Gly Gln Xaa His Leu Val Leu Ile Arg Glu Glu Ala Gly Ala Pro 
    450                 455                 460                 


Asp Ala Lys Phe Ser Gly Trp Ala Asp Ala Val Ile Phe Val Phe Ser 
465                 470                 475                 480 


Leu Glu Asp Glu Asn Ser Phe Gln Ala Val Ser Arg Leu His Gly Gln 
                485                 490                 495     


Leu Ser Ser Leu Arg Gly Glu Gly Arg Gly Gly Leu Ala Leu Ala Leu 
            500                 505                 510         


Val Gly Xaa Gln Asp Arg Ile Ser Ala Ser Ser Pro Arg Val Val Gly 
        515                 520                 525             


Asp Ala Arg Ala Arg Ala Leu Cys Ala Asp Met Lys Arg Cys Ser Tyr 
    530                 535                 540                 


Tyr Glu Xaa Cys Ala Xaa Tyr Gly Leu Asn Val Asp Arg Val Phe Gln 
545                 550                 555                 560 


Glu Val Ala Gln Lys Val Val Xaa Leu Arg Lys Gln Gln Gln Leu Leu 
                565                 570                 575     


Ala Ala Cys Lys Ser Leu Pro Ser Ser Pro Ser His Ser Ala Ala Ser 
            580                 585                 590         


Xaa Pro Val Ala Gly Gln Ala Ser Asn Gly Gly His Xaa Ser Asp Tyr 
        595                 600                 605             


Ser Ser Ser Leu Pro Ser Ser Pro Asn Val Gly His Arg Glu Leu Arg 
    610                 615                 620                 


Ala Glu Ala Ala Ala Val Ala Gly Leu Ser Xaa Pro Gly Ser Leu His 
625                 630                 635                 640 


Arg Ala Ala Lys Arg Arg Xaa Ser Leu Phe Ala Asn Arg Arg Gly Ser 
                645                 650                 655     


Asp Ser Glu Lys Arg Ser Leu Asp Ser Arg Gly Glu Xaa Xaa Gly Ser 
            660                 665                 670         


Gly Arg Ala Ile Pro Ile Lys Gln Ser Phe Leu Leu Lys Arg Ser Gly 
        675                 680                 685             


Asn Ser Leu Asn Lys Glu Trp Lys Lys Lys Tyr Val Xaa Leu Ser Ser 
    690                 695                 700                 


Asn Gly Phe Leu Leu Tyr His Pro Ser Ile Asn Asp Tyr Ile His Ser 
705                 710                 715                 720 


Xaa His Gly Lys Glu Met Asp Leu Leu Arg Xaa Xaa Val Lys Val Pro 
                725                 730                 735     


Gly Lys Arg Pro Pro Arg Ala Ile Ser Ala Phe Gly Pro Ser Ala Ser 
            740                 745                 750         


Ile Asn Gly Leu Val Lys Asp Met Ser Xaa Val Gln Met Gly Glu Gly 
        755                 760                 765             


Leu Glu Ala Xaa Xaa Pro Met Pro Ser Pro Ser Pro Ser Pro Ser Ser 
    770                 775                 780                 


Leu Gln Pro Pro Pro Asp Gln Xaa Ser Lys His Leu Leu Lys Pro Asp 
785                 790                 795                 800 


Arg Asn Leu Ala Arg Ala Leu Ser Xaa Asp Cys Xaa Pro Ser Gly Asp 
                805                 810                 815     


Leu Ser Pro Leu Ser Arg Glu Pro Pro Pro Ser Pro Met Val Lys Lys 
            820                 825                 830         


Gln Arg Arg Lys Lys Leu Xaa Xaa Pro Ser Lys Xaa Glu Gly Ser Ala 
        835                 840                 845             


Gly Gln Ala Glu Ala Lys Arg Lys Met Trp Lys Leu Lys Ser Phe Gly 
    850                 855                 860                 


Ser Leu Arg Asn Ile Tyr Lys Ala Glu Glu Asn Phe Glu Phe Leu Ile 
865                 870                 875                 880 


Val Ser Ser Xaa Gly Gln Xaa Trp His Phe Glu Ala Ala Ser Phe Glu 
                885                 890                 895     


Glu Arg Asp Ala Trp Val Gln Ala Ile Glu Ser Gln Ile Leu Ala Ser 
            900                 905                 910         


Leu Gln Cys Cys Glu Ser Ser Lys Val Lys Leu Arg Xaa Asp Ser Gln 
        915                 920                 925             


Ser Glu Ala Val Ala Ile Gln Ala Ile Arg Asn Ala Lys Gly Asn Ser 
    930                 935                 940                 


Ile Cys Val Asp Cys Gly Ala Pro Asn Pro Xaa Trp Ala Ser Leu Asn 
945                 950                 955                 960 


Leu Gly Ala Leu Ile Cys Ile Glu Cys Ser Gly Ile His Arg Asn Leu 
                965                 970                 975     


Gly Xaa His Leu Ser Arg Val Arg Ser Leu Asp Leu Asp Asp Trp Pro 
            980                 985                 990         


Arg Glu Leu Xaa Leu Val Leu Xaa  Ala Ile Gly Asn Asp  Xaa Ala Asn 
        995                 1000                 1005             


Arg Val  Trp Glu Ser Asp Xaa  Arg Gly Arg Ala Lys  Pro Ser Arg 
    1010                 1015                 1020             


Asp Ser  Ser Arg Glu Glu Arg  Glu Ser Trp Ile Arg  Ala Lys Tyr 
    1025                 1030                 1035             


Glu Gln  Leu Leu Phe Leu Ala  Pro Leu Ser Xaa Ser  Glu Glu Pro 
    1040                 1045                 1050             


Leu Gly  Arg Gln Leu Trp Ala  Ala Val Gln Ala Gln  Asp Val Ala 
    1055                 1060                 1065             


Xaa Val  Leu Leu Leu Leu Ala  His Ala Arg His Gly  Pro Leu Asp 
    1070                 1075                 1080             


Xaa Ser  Val Glu Asp Pro Gln  Leu Arg Ser Pro Leu  His Leu Ala 
    1085                 1090                 1095             


Ala Glu  Leu Ala His Val Val  Ile Xaa Gln Leu Leu  Leu Trp Tyr 
    1100                 1105                 1110             


Gly Ala  Asp Val Ala Ala Arg  Asp Ala Gln Gly Arg  Xaa Ala Leu 
    1115                 1120                 1125             


Phe Tyr  Ala Arg Gln Ala Gly  Ser Gln Leu Cys Ala  Asp Ile Leu 
    1130                 1135                 1140             


Leu Gln  His Gly Cys Pro Gly  Glu Gly Gly Ser Ala  Ala Xaa Xaa 
    1145                 1150                 1155             


Pro Ser  Ala Ala Xaa Xaa Pro  Ser Ile Xaa Ala Xaa  Pro Ser Pro 
    1160                 1165                 1170             


Arg Arg  Arg Ser Ser Ala Ala  Ser Val Gly Arg Ala  Asp Ala Pro 
    1175                 1180                 1185             


Val Ala  Leu Val 
    1190         


<210> 1936
<211> 169
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 1936
Arg Arg Xaa Ser Leu Phe Ala Asn Arg Arg Gly Ser Asp Ser Glu Lys 
1               5                   10                  15      


Arg Ser Leu Asp Ser Arg Gly Glu Xaa Xaa Gly Ser Gly Arg Ala Ile 
            20                  25                  30          


Pro Ile Lys Gln Ser Phe Leu Leu Lys Arg Ser Gly Asn Ser Leu Asn 
        35                  40                  45              


Lys Glu Trp Lys Lys Lys Tyr Val Xaa Leu Ser Ser Asn Gly Phe Leu 
    50                  55                  60                  


Leu Tyr His Pro Ser Ile Asn Asp Tyr Ile His Ser Xaa His Gly Lys 
65                  70                  75                  80  


Glu Met Asp Leu Leu Arg Xaa Xaa Val Lys Val Pro Gly Lys Arg Pro 
                85                  90                  95      


Pro Arg Ala Ile Ser Ala Phe Gly Pro Ser Ala Ser Ile Asn Gly Leu 
            100                 105                 110         


Val Lys Asp Met Ser Xaa Val Gln Met Gly Glu Gly Leu Glu Ala Xaa 
        115                 120                 125             


Xaa Pro Met Pro Ser Pro Ser Pro Ser Pro Ser Ser Leu Gln Pro Pro 
    130                 135                 140                 


Pro Asp Gln Xaa Ser Lys His Leu Leu Lys Pro Asp Arg Asn Leu Ala 
145                 150                 155                 160 


Arg Ala Leu Ser Xaa Gly Gln Trp Gly 
                165                 


<210> 1937
<211> 1036
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1007)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<400> 1937
Xaa Xaa Ser Ser Arg Arg Pro Leu Leu Ser Ser Pro Ser Trp Gly Gly 
1               5                   10                  15      


Pro Glu Pro Glu Gly Arg Ala Gly Gly Gly Ile Pro Gly Ser Ser Ser 
            20                  25                  30          


Pro His Pro Gly Xaa Gly Ser Arg Arg Leu Lys Val Ala Pro Pro Pro 
        35                  40                  45              


Pro Ala Pro Lys Pro Cys Lys Xaa Val Xaa Xaa Ser Gly Ala Lys Ala 
    50                  55                  60                  


Gly Gly Gly Lys Gly Ala Gly Ser Arg Leu Ser Trp Pro Glu Ser Glu 
65                  70                  75                  80  


Gly Lys Pro Arg Val Lys Gly Ser Lys Ser Ser Ala Gly Xaa Gly Ala 
                85                  90                  95      


Ser Val Ser Ala Ala Ala Xaa Ala Ala Ala Ala Gly Gly Gly Gly Ser 
            100                 105                 110         


Xaa Ala Ser Xaa Ser Gly Gly Val Gly Ala Gly Ala Gly Ala Arg Gly 
        115                 120                 125             


Lys Leu Ser Pro Arg Lys Gly Lys Ser Lys Xaa Leu Asp Asn Ser Asp 
    130                 135                 140                 


Leu His Pro Gly Pro Pro Ala Gly Ser Pro Pro Pro Leu Xaa Leu Pro 
145                 150                 155                 160 


Pro Xaa Pro Ser Pro Ala Xaa Ala Val Xaa Ala Ala Ser Ala Gln Pro 
                165                 170                 175     


Pro Gly Pro Ala Pro Pro Ile Xaa Leu Glu Pro Pro Ala Pro Gly Leu 
            180                 185                 190         


Lys Arg Gly Arg Glu Gly Gly Arg Ala Ser Xaa Arg Asp Arg Lys Met 
        195                 200                 205             


Leu Lys Phe Ile Ser Gly Ile Phe Xaa Lys Ser Xaa Gly Gly Pro Pro 
    210                 215                 220                 


Gly Ser Gly Pro Leu Pro Gly Pro Pro Ser Leu Ser Ser Gly Ser Gly 
225                 230                 235                 240 


Ser Arg Glu Leu Leu Gly Ala Glu Leu Arg Ala Ser Pro Lys Ala Val 
                245                 250                 255     


Ile Asn Ser Gln Glu Trp Xaa Leu Ser Arg Ser Ile Pro Glu Leu Arg 
            260                 265                 270         


Leu Gly Val Leu Gly Asp Ala Arg Ser Gly Lys Ser Ser Leu Ile His 
        275                 280                 285             


Arg Phe Leu Xaa Gly Ser Tyr Gln Val Leu Glu Lys Xaa Glu Ser Glu 
    290                 295                 300                 


Gln Tyr Lys Lys Glu Met Leu Val Asp Gly Gln Xaa His Leu Val Leu 
305                 310                 315                 320 


Ile Arg Glu Glu Ala Gly Ala Pro Asp Ala Lys Phe Ser Gly Trp Ala 
                325                 330                 335     


Asp Ala Val Ile Phe Val Phe Ser Leu Glu Asp Glu Asn Ser Phe Gln 
            340                 345                 350         


Ala Val Ser Arg Leu His Gly Gln Leu Ser Ser Leu Arg Gly Glu Gly 
        355                 360                 365             


Arg Gly Gly Leu Ala Leu Ala Leu Val Gly Xaa Gln Asp Arg Ile Ser 
    370                 375                 380                 


Ala Ser Ser Pro Arg Val Val Gly Asp Ala Arg Ala Arg Ala Leu Cys 
385                 390                 395                 400 


Ala Asp Met Lys Arg Cys Ser Tyr Tyr Glu Xaa Cys Ala Xaa Tyr Gly 
                405                 410                 415     


Leu Asn Val Asp Arg Val Phe Gln Glu Val Ala Gln Lys Val Val Xaa 
            420                 425                 430         


Leu Arg Lys Gln Gln Gln Leu Leu Ala Ala Cys Lys Ser Leu Pro Ser 
        435                 440                 445             


Ser Pro Ser His Ser Ala Ala Ser Xaa Pro Val Ala Gly Gln Ala Ser 
    450                 455                 460                 


Asn Gly Gly His Xaa Ser Asp Tyr Ser Ser Ser Leu Pro Ser Ser Pro 
465                 470                 475                 480 


Asn Val Gly His Arg Glu Leu Arg Ala Glu Ala Ala Ala Val Ala Gly 
                485                 490                 495     


Leu Ser Xaa Pro Gly Ser Leu His Arg Ala Ala Lys Arg Arg Xaa Ser 
            500                 505                 510         


Leu Phe Ala Asn Arg Arg Gly Ser Asp Ser Glu Lys Arg Ser Leu Asp 
        515                 520                 525             


Ser Arg Gly Glu Xaa Xaa Gly Ser Gly Arg Ala Ile Pro Ile Lys Gln 
    530                 535                 540                 


Ser Phe Leu Leu Lys Arg Ser Gly Asn Ser Leu Asn Lys Glu Trp Lys 
545                 550                 555                 560 


Lys Lys Tyr Val Xaa Leu Ser Ser Asn Gly Phe Leu Leu Tyr His Pro 
                565                 570                 575     


Ser Ile Asn Asp Tyr Ile His Ser Xaa His Gly Lys Glu Met Asp Leu 
            580                 585                 590         


Leu Arg Xaa Xaa Val Lys Val Pro Gly Lys Arg Pro Pro Arg Ala Ile 
        595                 600                 605             


Ser Ala Phe Gly Pro Ser Ala Ser Ile Asn Gly Leu Val Lys Asp Met 
    610                 615                 620                 


Ser Xaa Val Gln Met Gly Glu Gly Leu Glu Ala Xaa Xaa Pro Met Pro 
625                 630                 635                 640 


Ser Pro Ser Pro Ser Pro Ser Ser Leu Gln Pro Pro Pro Asp Gln Xaa 
                645                 650                 655     


Ser Lys His Leu Leu Lys Pro Asp Arg Asn Leu Ala Arg Ala Leu Ser 
            660                 665                 670         


Xaa Asp Cys Xaa Pro Ser Gly Asp Leu Ser Pro Leu Ser Arg Glu Pro 
        675                 680                 685             


Pro Pro Ser Pro Met Val Lys Lys Gln Arg Arg Lys Lys Leu Xaa Xaa 
    690                 695                 700                 


Pro Ser Lys Xaa Glu Gly Ser Ala Gly Gln Ala Glu Glu Glu Asn Phe 
705                 710                 715                 720 


Glu Phe Leu Ile Val Ser Ser Xaa Gly Gln Xaa Trp His Phe Glu Ala 
                725                 730                 735     


Ala Ser Phe Glu Glu Arg Asp Ala Trp Val Gln Ala Ile Glu Ser Gln 
            740                 745                 750         


Ile Leu Ala Ser Leu Gln Cys Cys Glu Ser Ser Lys Val Lys Leu Arg 
        755                 760                 765             


Xaa Asp Ser Gln Ser Glu Ala Val Ala Ile Gln Ala Ile Arg Asn Ala 
    770                 775                 780                 


Lys Gly Asn Ser Ile Cys Val Asp Cys Gly Ala Pro Asn Pro Xaa Trp 
785                 790                 795                 800 


Ala Ser Leu Asn Leu Gly Ala Leu Ile Cys Ile Glu Cys Ser Gly Ile 
                805                 810                 815     


His Arg Asn Leu Gly Xaa His Leu Ser Arg Val Arg Ser Leu Asp Leu 
            820                 825                 830         


Asp Asp Trp Pro Arg Glu Leu Xaa Leu Val Leu Xaa Ala Ile Gly Asn 
        835                 840                 845             


Asp Xaa Ala Asn Arg Val Trp Glu Ser Asp Xaa Arg Gly Arg Ala Lys 
    850                 855                 860                 


Pro Ser Arg Asp Ser Ser Arg Glu Glu Arg Glu Ser Trp Ile Arg Ala 
865                 870                 875                 880 


Lys Tyr Glu Gln Leu Leu Phe Leu Ala Pro Leu Ser Xaa Ser Glu Glu 
                885                 890                 895     


Pro Leu Gly Arg Gln Leu Trp Ala Ala Val Gln Ala Gln Asp Val Ala 
            900                 905                 910         


Xaa Val Leu Leu Leu Leu Ala His Ala Arg His Gly Pro Leu Asp Xaa 
        915                 920                 925             


Ser Val Glu Asp Pro Gln Leu Arg Ser Pro Leu His Leu Ala Ala Glu 
    930                 935                 940                 


Leu Ala His Val Val Ile Xaa Gln Leu Leu Leu Trp Tyr Gly Ala Asp 
945                 950                 955                 960 


Val Ala Ala Arg Asp Ala Gln Gly Arg Xaa Ala Leu Phe Tyr Ala Arg 
                965                 970                 975     


Gln Ala Gly Ser Gln Leu Cys Ala Asp Ile Leu Leu Gln His Gly Cys 
            980                 985                 990         


Pro Gly Glu Gly Gly Ser Ala Ala  Xaa Xaa Pro Ser Ala  Ala Xaa Xaa 
        995                 1000                 1005             


Pro Ser  Ile Xaa Ala Xaa Pro  Ser Pro Arg Arg Arg  Ser Ser Ala 
    1010                 1015                 1020             


Ala Ser  Val Gly Arg Ala Asp  Ala Pro Val Ala Leu  Val 
    1025                 1030                 1035     


<210> 1938
<211> 177
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<400> 1938
Asp Ala Ile Ser Ala Ala Asn Pro Arg Val Ile Asp Asp Ser Arg Ala 
1               5                   10                  15      


Arg Lys Leu Ser Xaa Asp Leu Lys Arg Cys Xaa Tyr Tyr Glu Xaa Cys 
            20                  25                  30          


Ala Xaa Tyr Gly Leu Asn Val Glu Arg Val Phe Gln Asp Val Ala Gln 
        35                  40                  45              


Lys Val Val Ala Leu Arg Lys Lys Gln Gln Leu Ala Ile Gly Pro Cys 
    50                  55                  60                  


Lys Ser Leu Pro Asn Ser Pro Ser His Ser Ala Val Ser Ala Ala Ser 
65                  70                  75                  80  


Ile Pro Ala Val His Ile Asn Gln Ala Xaa Asn Gly Gly Gly Ser Ala 
                85                  90                  95      


Phe Ser Asp Tyr Ser Ser Ser Val Pro Ser Xaa Pro Ser Ile Ser Gln 
            100                 105                 110         


Arg Glu Leu Arg Ile Glu Xaa Ile Ala Ala Ser Ser Xaa Pro Xaa Pro 
        115                 120                 125             


Ile Arg Lys Gln Ser Lys Arg Arg Ser Asn Ile Phe Xaa Leu Met Asn 
    130                 135                 140                 


Arg Arg Pro Glu Gly Cys Leu Pro Lys Ala Xaa Gln Arg Ile Cys Ala 
145                 150                 155                 160 


Xaa Val Ser Asn Phe Ser Ser Xaa Lys Arg Pro Phe Gln Leu Leu Pro 
                165                 170                 175     


Asn 
    


<210> 1939
<211> 576
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<400> 1939
Met Glu Arg Gly Trp Pro Gln Gly Asp Ser Cys Pro Gly Glu Arg Pro 
1               5                   10                  15      


Ala Ala Cys Arg Arg Ala His Ser Val Cys Asp Ser Leu Asp Leu His 
            20                  25                  30          


Gly Ala Ser Ala Gly Arg Ala Ala Ala Ala Leu Gln Ala Ala Leu Cys 
        35                  40                  45              


Ala Ala Ser Glu Gln Pro Ala Arg Pro Arg Ser Val Cys Ser Gly Gly 
    50                  55                  60                  


Pro Glu Pro Pro Pro Xaa Gly Ala Arg Gly Leu Leu Leu Gly Leu Leu 
65                  70                  75                  80  


Arg Pro Arg Leu Gly Arg Arg Gly Leu Ala Pro Ser Gly Pro Pro Val 
                85                  90                  95      


Ser Pro Ala Pro Ser Pro Ala Ser Ser Pro Ala Pro Xaa Arg Arg Ser 
            100                 105                 110         


Arg Xaa Arg Gly Glu Pro Xaa Pro Arg Pro Arg Pro Ala Ser Met Xaa 
        115                 120                 125             


Phe Leu Glu Val Asn Arg Leu Glu Leu Ala Ala Ala Glu Ala Pro Gly 
    130                 135                 140                 


Ala Gly Leu Gly Arg Ala Gly Ser Ala Gly Phe Leu Arg Gly Ala Ala 
145                 150                 155                 160 


Leu Trp Ser Ser Gln Arg Trp Pro Val Leu Arg Gly Gly Arg Gly Pro 
                165                 170                 175     


Glu Gly Pro Arg Arg Gly Leu Ala Ala Leu Arg Lys Ser Phe Ser Phe 
            180                 185                 190         


Arg Leu Arg Arg Gly Gln Glu Val Arg Arg Ser Glu Ser Gly Leu Leu 
        195                 200                 205             


Ala Arg Pro Pro Arg Ala Arg Xaa Arg Ser Asp Gly Asp Ala Gly Ser 
    210                 215                 220                 


Leu Gly Ala Phe Pro Ser Arg Arg Asp Leu Leu Gly Ser Asp Ala Pro 
225                 230                 235                 240 


Arg Ala Ala Pro Glu Pro Gly Arg Pro Arg Xaa Ala Ala Gly Leu Trp 
                245                 250                 255     


Arg Leu Leu Xaa Ser Arg Phe Arg Arg Arg Glu Pro Ala Pro Ala Ala 
            260                 265                 270         


Pro Leu Trp Gly Arg Arg Ala Ala Ala Ala Pro Glu Leu Leu Arg Ala 
        275                 280                 285             


Pro Ser Asp Ser Phe Val Asn Ser Gln Glu Trp Xaa Leu Ser Arg Ser 
    290                 295                 300                 


Val Pro Glu Leu Lys Val Gly Ile Val Gly Asn Leu Ser Ser Gly Lys 
305                 310                 315                 320 


Ser Ala Leu Val His Arg Tyr Leu Xaa Gly Xaa Tyr Val Gln Glu Glu 
                325                 330                 335     


Ser Pro Glu Gly Gly Arg Phe Lys Lys Glu Ile Val Val Asp Gly Gln 
            340                 345                 350         


Ser Tyr Leu Leu Leu Ile Arg Asp Glu Gly Gly Pro Pro Glu Leu Gln 
        355                 360                 365             


Phe Ala Ala Trp Val Asp Ala Val Val Phe Val Phe Ser Leu Glu Asp 
    370                 375                 380                 


Glu Ile Ser Phe Gln Xaa Val Tyr Asn Tyr Phe Leu Arg Leu Cys Ser 
385                 390                 395                 400 


Phe Arg Asn Ala Ser Glu Val Pro Met Val Leu Val Gly Xaa Gln Asp 
                405                 410                 415     


Ala Ile Ser Ala Ala Asn Pro Arg Val Ile Asp Asp Ser Arg Ala Arg 
            420                 425                 430         


Lys Leu Ser Xaa Asp Leu Lys Arg Cys Xaa Tyr Tyr Glu Xaa Cys Ala 
        435                 440                 445             


Xaa Tyr Gly Leu Asn Val Glu Arg Val Phe Gln Asp Val Ala Gln Lys 
    450                 455                 460                 


Val Val Ala Leu Arg Lys Lys Gln Gln Leu Ala Ile Gly Pro Cys Lys 
465                 470                 475                 480 


Ser Leu Pro Asn Ser Pro Ser His Ser Ala Val Ser Ala Ala Ser Ile 
                485                 490                 495     


Pro Ala Val His Ile Asn Gln Ala Xaa Asn Gly Gly Gly Ser Ala Phe 
            500                 505                 510         


Ser Asp Tyr Ser Ser Ser Val Pro Ser Xaa Pro Ser Ile Ser Gln Arg 
        515                 520                 525             


Glu Leu Arg Ile Glu Xaa Ile Ala Ala Ser Ser Xaa Pro Xaa Pro Ile 
    530                 535                 540                 


Arg Lys Gln Ser Lys Arg Arg Ser Asn Ile Phe Xaa Ile Cys Ala Xaa 
545                 550                 555                 560 


Val Ser Asn Phe Ser Ser Xaa Lys Arg Pro Phe Gln Leu Leu Pro Asn 
                565                 570                 575     


<210> 1940
<211> 875
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<400> 1940
Met Asn Phe Gln Ala Gly Gly Gly Gln Ser Pro Gln Gln Gln Gln Gln 
1               5                   10                  15      


Leu Ala Gly Gly Pro Pro Gln Gln Phe Ala Leu Ser Asn Ser Ala Ala 
            20                  25                  30          


Ile Arg Ala Glu Ile Gln Arg Phe Glu Ser Val His Pro Asn Ile Tyr 
        35                  40                  45              


Ala Ile Tyr Asp Leu Ile Glu Arg Ile Glu Asp Leu Ala Leu Gln Asn 
    50                  55                  60                  


Gln Ile Arg Glu His Val Ile Ser Ile Glu Asp Ser Phe Val Asn Ser 
65                  70                  75                  80  


Gln Glu Trp Xaa Leu Ser Arg Ser Val Pro Glu Leu Lys Val Gly Ile 
                85                  90                  95      


Val Gly Asn Leu Ser Ser Gly Lys Ser Ala Leu Val His Arg Tyr Leu 
            100                 105                 110         


Xaa Gly Xaa Tyr Val Gln Glu Glu Ser Pro Glu Gly Gly Arg Phe Lys 
        115                 120                 125             


Lys Glu Ile Val Val Asp Gly Gln Ser Tyr Leu Leu Leu Ile Arg Asp 
    130                 135                 140                 


Glu Gly Gly Pro Pro Glu Leu Gln Phe Ala Ala Trp Val Asp Ala Val 
145                 150                 155                 160 


Val Phe Val Phe Ser Leu Glu Asp Glu Ile Ser Phe Gln Xaa Val Tyr 
                165                 170                 175     


Asn Tyr Phe Leu Arg Leu Cys Ser Phe Arg Asn Ala Ser Glu Val Pro 
            180                 185                 190         


Met Val Leu Val Gly Xaa Gln Asp Ala Ile Ser Ala Ala Asn Pro Arg 
        195                 200                 205             


Val Ile Asp Asp Ser Arg Ala Arg Lys Leu Ser Xaa Asp Leu Lys Arg 
    210                 215                 220                 


Cys Xaa Tyr Tyr Glu Xaa Cys Ala Xaa Tyr Gly Leu Asn Val Glu Arg 
225                 230                 235                 240 


Val Phe Gln Asp Val Ala Gln Lys Val Val Ala Leu Arg Lys Lys Gln 
                245                 250                 255     


Gln Leu Ala Ile Gly Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser His 
            260                 265                 270         


Ser Ala Val Ser Ala Ala Ser Ile Pro Ala Val His Ile Asn Gln Ala 
        275                 280                 285             


Xaa Asn Gly Gly Gly Ser Ala Phe Ser Asp Tyr Ser Ser Ser Val Pro 
    290                 295                 300                 


Ser Xaa Pro Ser Ile Ser Gln Arg Glu Leu Arg Ile Glu Xaa Ile Ala 
305                 310                 315                 320 


Ala Ser Ser Xaa Pro Xaa Pro Ile Arg Lys Gln Ser Lys Arg Arg Ser 
                325                 330                 335     


Asn Ile Phe Xaa Ser Arg Lys Gly Ala Asp Leu Asp Arg Glu Lys Lys 
            340                 345                 350         


Ala Ala Glu Cys Lys Val Asp Ser Ile Gly Ser Gly Arg Ala Ile Pro 
        355                 360                 365             


Ile Lys Gln Gly Ile Leu Leu Lys Arg Ser Gly Lys Ser Leu Asn Lys 
    370                 375                 380                 


Glu Trp Lys Lys Lys Tyr Val Xaa Leu Cys Asp Asn Gly Leu Leu Xaa 
385                 390                 395                 400 


Tyr His Pro Ser Leu His Asp Tyr Met Gln Asn Ile His Gly Lys Glu 
                405                 410                 415     


Ile Asp Leu Leu Arg Xaa Xaa Val Lys Val Pro Gly Lys Arg Leu Pro 
            420                 425                 430         


Arg Ala Xaa Pro Ala Xaa Ala Pro Gly Xaa Ser Pro Arg Ala Asn Gly 
        435                 440                 445             


Leu Ser Val Glu Arg Ser Asn Xaa Gln Leu Gly Gly Gly Xaa Gly Ala 
    450                 455                 460                 


Pro His Ser Ala Ser Ser Ala Ser Leu His Ser Glu Arg Pro Leu Ser 
465                 470                 475                 480 


Ser Ser Ala Trp Ala Gly Pro Arg Pro Glu Gly Leu His Gln Arg Ser 
                485                 490                 495     


Cys Ser Val Ser Ser Ala Asp Gln Trp Ser Glu Ala Xaa Xaa Ser Leu 
            500                 505                 510         


Pro Pro Gly Met Gln His Pro Ala Ser Gly Pro Ala Glu Val Leu Ser 
        515                 520                 525             


Ser Ser Pro Lys Leu Asp Pro Pro Pro Ser Pro His Ser Asn Arg Lys 
    530                 535                 540                 


Lys His Arg Arg Lys Lys Ser Xaa Gly Xaa Pro Arg Pro Asp Gly Pro 
545                 550                 555                 560 


Ser Ser Ala Xaa Glu Glu Ala Glu Glu Ser Phe Glu Phe Val Val Val 
                565                 570                 575     


Ser Leu Xaa Gly Gln Xaa Trp His Phe Glu Ala Ser Xaa Ala Glu Glu 
            580                 585                 590         


Arg Glu Leu Trp Val Gln Ser Val Gln Ala Gln Ile Leu Ala Ser Leu 
        595                 600                 605             


Gln Gly Cys Arg Ser Ala Lys Asp Lys Xaa Arg Leu Gly Asn Gln Asn 
    610                 615                 620                 


Ala Ala Leu Ala Val Gln Ala Val Arg Xaa Val Arg Gly Asn Ser Phe 
625                 630                 635                 640 


Cys Ile Asp Cys Asp Ala Pro Asn Pro Asp Trp Ala Ser Leu Asn Leu 
                645                 650                 655     


Gly Ala Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg His Leu Gly 
            660                 665                 670         


Ala His Leu Ser Arg Val Arg Ser Leu Asp Leu Asp Asp Trp Pro Pro 
        675                 680                 685             


Glu Leu Leu Ala Val Met Xaa Ala Met Gly Asn Ala Leu Ala Asn Ser 
    690                 695                 700                 


Val Trp Glu Gly Ala Leu Gly Gly Tyr Ser Lys Pro Gly Pro Asp Ala 
705                 710                 715                 720 


Cys Arg Glu Glu Lys Glu Arg Trp Ile Arg Ala Lys Tyr Glu Gln Lys 
                725                 730                 735     


Leu Phe Leu Ala Pro Leu Pro Ser Ser Asp Val Pro Leu Gly Gln Gln 
            740                 745                 750         


Leu Leu Arg Ala Val Val Glu Asp Asp Leu Arg Leu Leu Val Met Leu 
        755                 760                 765             


Leu Ala His Gly Ser Lys Glu Glu Val Asn Glu Xaa Tyr Gly Asp Gly 
    770                 775                 780                 


Asp Gly Arg Xaa Ala Leu His Leu Ser Ser Ala Met Ala Asn Val Val 
785                 790                 795                 800 


Phe Xaa Gln Leu Leu Ile Trp Tyr Gly Val Asp Val Arg Ser Arg Asp 
                805                 810                 815     


Ala Arg Gly Leu Xaa Pro Leu Ala Tyr Ala Arg Arg Ala Gly Ser Gln 
            820                 825                 830         


Glu Cys Ala Asp Ile Leu Ile Gln His Gly Cys Pro Gly Glu Gly Cys 
        835                 840                 845             


Gly Leu Ala Pro Xaa Pro Asn Arg Glu Pro Ala Asn Gly Xaa Asn Pro 
    850                 855                 860                 


Ser Ala Glu Leu His Arg Ser Pro Ser Leu Leu 
865                 870                 875 


<210> 1941
<211> 343
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<400> 1941
Met Asn Phe Gln Ala Gly Gly Gly Gln Ser Pro Gln Gln Gln Gln Ser 
1               5                   10                  15      


Leu Ala Ala Pro Gly Gly Gly Gly Ala Ala Ala Gln Gln Leu Val Cys 
            20                  25                  30          


Gly Gly Gln Phe Gly Gly Ala Gly Pro Gly Ala Gly Gly Gly Gly Gly 
        35                  40                  45              


Pro Ser Gln Gln Leu Ala Gly Gly Pro Pro Gln Gln Phe Ala Leu Ser 
    50                  55                  60                  


Asn Ser Ala Ala Ile Arg Ala Glu Ile Gln Arg Phe Glu Ser Val His 
65                  70                  75                  80  


Pro Asn Ile Tyr Ala Ile Tyr Asp Leu Ile Glu Arg Ile Glu Asp Leu 
                85                  90                  95      


Ala Leu Gln Asn Gln Ile Arg Glu His Val Ile Ser Ile Glu Asp Ser 
            100                 105                 110         


Phe Val Asn Ser Gln Glu Trp Xaa Leu Ser Arg Ser Val Pro Glu Leu 
        115                 120                 125             


Lys Val Gly Ile Val Gly Asn Leu Ser Ser Gly Lys Ser Ala Leu Val 
    130                 135                 140                 


His Arg Tyr Leu Xaa Gly Xaa Tyr Val Gln Glu Glu Ser Pro Glu Gly 
145                 150                 155                 160 


Gly Arg Phe Lys Lys Glu Ile Val Val Asp Gly Gln Ser Tyr Leu Leu 
                165                 170                 175     


Leu Ile Arg Asp Glu Gly Gly Pro Pro Glu Leu Gln Phe Ala Ala Trp 
            180                 185                 190         


Val Asp Ala Val Val Phe Val Phe Ser Leu Glu Asp Glu Ile Ser Phe 
        195                 200                 205             


Gln Xaa Val Tyr Asn Tyr Phe Leu Arg Leu Cys Ser Phe Arg Asn Ala 
    210                 215                 220                 


Ser Glu Val Pro Met Val Leu Val Gly Xaa Gln Asp Ala Ile Ser Ala 
225                 230                 235                 240 


Ala Asn Pro Arg Val Ile Asp Asp Ser Arg Ala Arg Lys Leu Ser Xaa 
                245                 250                 255     


Asp Leu Lys Arg Cys Xaa Tyr Tyr Glu Xaa Cys Ala Xaa Tyr Gly Leu 
            260                 265                 270         


Asn Val Glu Arg Val Phe Gln Asp Val Ala Gln Lys Val Val Ala Leu 
        275                 280                 285             


Arg Lys Lys Gln Gln Leu Ala Ile Gly Pro Cys Lys Ser Leu Pro Asn 
    290                 295                 300                 


Ser Pro Ser His Ser Ala Val Ser Ala Ala Ser Ile Pro Ala Val His 
305                 310                 315                 320 


Ile Asn Gln Ile Cys Ala Xaa Val Ser Asn Phe Ser Ser Xaa Lys Arg 
                325                 330                 335     


Pro Phe Gln Leu Leu Pro Asn 
            340             


<210> 1942
<211> 396
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<400> 1942
Met Asn Phe Gln Ala Gly Gly Gly Gln Ser Pro Gln Gln Gln Gln Ser 
1               5                   10                  15      


Leu Ala Ala Pro Gly Gly Gly Gly Ala Ala Ala Gln Gln Leu Val Cys 
            20                  25                  30          


Gly Gly Gln Phe Gly Gly Ala Gly Pro Gly Ala Gly Gly Gly Gly Gly 
        35                  40                  45              


Pro Ser Gln Gln Leu Ala Gly Gly Pro Pro Gln Gln Phe Ala Leu Ser 
    50                  55                  60                  


Asn Ser Ala Ala Ile Arg Ala Glu Ile Gln Arg Phe Glu Ser Val His 
65                  70                  75                  80  


Pro Asn Ile Tyr Ala Ile Tyr Asp Leu Ile Glu Arg Ile Glu Asp Leu 
                85                  90                  95      


Ala Leu Gln Asn Gln Ile Arg Glu His Val Ile Ser Ile Glu Asp Ser 
            100                 105                 110         


Phe Val Asn Ser Gln Glu Trp Xaa Leu Ser Arg Ser Val Pro Glu Leu 
        115                 120                 125             


Lys Val Gly Ile Val Gly Asn Leu Ser Ser Gly Lys Ser Ala Leu Val 
    130                 135                 140                 


His Arg Tyr Leu Xaa Gly Xaa Tyr Val Gln Glu Glu Ser Pro Glu Gly 
145                 150                 155                 160 


Gly Arg Phe Lys Lys Glu Ile Val Val Asp Gly Gln Ser Tyr Leu Leu 
                165                 170                 175     


Leu Ile Arg Asp Glu Gly Gly Pro Pro Glu Leu Gln Phe Ala Ala Trp 
            180                 185                 190         


Val Asp Ala Val Val Phe Val Phe Ser Leu Glu Asp Glu Ile Ser Phe 
        195                 200                 205             


Gln Xaa Val Tyr Asn Tyr Phe Leu Arg Leu Cys Ser Phe Arg Asn Ala 
    210                 215                 220                 


Ser Glu Val Pro Met Val Leu Val Gly Xaa Gln Asp Ala Ile Ser Ala 
225                 230                 235                 240 


Ala Asn Pro Arg Val Ile Asp Asp Ser Arg Ala Arg Lys Leu Ser Xaa 
                245                 250                 255     


Asp Leu Lys Arg Cys Xaa Tyr Tyr Glu Xaa Cys Ala Xaa Tyr Gly Leu 
            260                 265                 270         


Asn Val Glu Arg Val Phe Gln Asp Val Ala Gln Lys Val Val Ala Leu 
        275                 280                 285             


Arg Lys Lys Gln Gln Leu Ala Ile Gly Pro Cys Lys Ser Leu Pro Asn 
    290                 295                 300                 


Ser Pro Ser His Ser Ala Val Ser Ala Ala Ser Ile Pro Ala Val His 
305                 310                 315                 320 


Ile Asn Gln Ala Xaa Asn Gly Gly Gly Ser Ala Phe Ser Asp Tyr Ser 
                325                 330                 335     


Ser Ser Val Pro Ser Xaa Pro Ser Ile Ser Gln Arg Glu Leu Arg Ile 
            340                 345                 350         


Glu Xaa Ile Ala Ala Ser Ser Xaa Pro Xaa Pro Ile Arg Lys Gln Ser 
        355                 360                 365             


Lys Arg Arg Ser Asn Ile Phe Xaa Ile Cys Ala Xaa Val Ser Asn Phe 
    370                 375                 380                 


Ser Ser Xaa Lys Arg Pro Phe Gln Leu Leu Pro Asn 
385                 390                 395     


<210> 1943
<211> 911
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<400> 1943
Met Asn Phe Gln Ala Gly Gly Gly Gln Ser Pro Gln Gln Gln Gln Ser 
1               5                   10                  15      


Leu Ala Ala Pro Gly Gly Gly Gly Ala Ala Ala Gln Gln Leu Val Cys 
            20                  25                  30          


Gly Gly Gln Phe Gly Gly Ala Gly Pro Gly Ala Gly Gly Gly Gly Gly 
        35                  40                  45              


Pro Ser Gln Gln Leu Ala Gly Gly Pro Pro Gln Gln Phe Ala Leu Ser 
    50                  55                  60                  


Asn Ser Ala Ala Ile Arg Ala Glu Ile Gln Arg Phe Glu Ser Val His 
65                  70                  75                  80  


Pro Asn Ile Tyr Ala Ile Tyr Asp Leu Ile Glu Arg Ile Glu Asp Leu 
                85                  90                  95      


Ala Leu Gln Asn Gln Ile Arg Glu His Val Ile Ser Ile Glu Asp Ser 
            100                 105                 110         


Phe Val Asn Ser Gln Glu Trp Xaa Leu Ser Arg Ser Val Pro Glu Leu 
        115                 120                 125             


Lys Val Gly Ile Val Gly Asn Leu Ser Ser Gly Lys Ser Ala Leu Val 
    130                 135                 140                 


His Arg Tyr Leu Xaa Gly Xaa Tyr Val Gln Glu Glu Ser Pro Glu Gly 
145                 150                 155                 160 


Gly Arg Phe Lys Lys Glu Ile Val Val Asp Gly Gln Ser Tyr Leu Leu 
                165                 170                 175     


Leu Ile Arg Asp Glu Gly Gly Pro Pro Glu Leu Gln Phe Ala Ala Trp 
            180                 185                 190         


Val Asp Ala Val Val Phe Val Phe Ser Leu Glu Asp Glu Ile Ser Phe 
        195                 200                 205             


Gln Xaa Val Tyr Asn Tyr Phe Leu Arg Leu Cys Ser Phe Arg Asn Ala 
    210                 215                 220                 


Ser Glu Val Pro Met Val Leu Val Gly Xaa Gln Asp Ala Ile Ser Ala 
225                 230                 235                 240 


Ala Asn Pro Arg Val Ile Asp Asp Ser Arg Ala Arg Lys Leu Ser Xaa 
                245                 250                 255     


Asp Leu Lys Arg Cys Xaa Tyr Tyr Glu Xaa Cys Ala Xaa Tyr Gly Leu 
            260                 265                 270         


Asn Val Glu Arg Val Phe Gln Asp Val Ala Gln Lys Val Val Ala Leu 
        275                 280                 285             


Arg Lys Lys Gln Gln Leu Ala Ile Gly Pro Cys Lys Ser Leu Pro Asn 
    290                 295                 300                 


Ser Pro Ser His Ser Ala Val Ser Ala Ala Ser Ile Pro Ala Val His 
305                 310                 315                 320 


Ile Asn Gln Ala Xaa Asn Gly Gly Gly Ser Ala Phe Ser Asp Tyr Ser 
                325                 330                 335     


Ser Ser Val Pro Ser Xaa Pro Ser Ile Ser Gln Arg Glu Leu Arg Ile 
            340                 345                 350         


Glu Xaa Ile Ala Ala Ser Ser Xaa Pro Xaa Pro Ile Arg Lys Gln Ser 
        355                 360                 365             


Lys Arg Arg Ser Asn Ile Phe Xaa Ser Arg Lys Gly Ala Asp Leu Asp 
    370                 375                 380                 


Arg Glu Lys Lys Ala Ala Glu Cys Lys Val Asp Ser Ile Gly Ser Gly 
385                 390                 395                 400 


Arg Ala Ile Pro Ile Lys Gln Gly Ile Leu Leu Lys Arg Ser Gly Lys 
                405                 410                 415     


Ser Leu Asn Lys Glu Trp Lys Lys Lys Tyr Val Xaa Leu Cys Asp Asn 
            420                 425                 430         


Gly Leu Leu Xaa Tyr His Pro Ser Leu His Asp Tyr Met Gln Asn Ile 
        435                 440                 445             


His Gly Lys Glu Ile Asp Leu Leu Arg Xaa Xaa Val Lys Val Pro Gly 
    450                 455                 460                 


Lys Arg Leu Pro Arg Ala Xaa Pro Ala Xaa Ala Pro Gly Xaa Ser Pro 
465                 470                 475                 480 


Arg Ala Asn Gly Leu Ser Val Glu Arg Ser Asn Xaa Gln Leu Gly Gly 
                485                 490                 495     


Gly Xaa Gly Ala Pro His Ser Ala Ser Ser Ala Ser Leu His Ser Glu 
            500                 505                 510         


Arg Pro Leu Ser Ser Ser Ala Trp Ala Gly Pro Arg Pro Glu Gly Leu 
        515                 520                 525             


His Gln Arg Ser Cys Ser Val Ser Ser Ala Asp Gln Trp Ser Glu Ala 
    530                 535                 540                 


Xaa Xaa Ser Leu Pro Pro Gly Met Gln His Pro Ala Ser Gly Pro Ala 
545                 550                 555                 560 


Glu Val Leu Ser Ser Ser Pro Lys Leu Asp Pro Pro Pro Ser Pro His 
                565                 570                 575     


Ser Asn Arg Lys Lys His Arg Arg Lys Lys Ser Xaa Gly Xaa Pro Arg 
            580                 585                 590         


Pro Asp Gly Pro Ser Ser Ala Xaa Glu Glu Ala Glu Glu Ser Phe Glu 
        595                 600                 605             


Phe Val Val Val Ser Leu Xaa Gly Gln Xaa Trp His Phe Glu Ala Ser 
    610                 615                 620                 


Xaa Ala Glu Glu Arg Glu Leu Trp Val Gln Ser Val Gln Ala Gln Ile 
625                 630                 635                 640 


Leu Ala Ser Leu Gln Gly Cys Arg Ser Ala Lys Asp Lys Xaa Arg Leu 
                645                 650                 655     


Gly Asn Gln Asn Ala Ala Leu Ala Val Gln Ala Val Arg Xaa Val Arg 
            660                 665                 670         


Gly Asn Ser Phe Cys Ile Asp Cys Asp Ala Pro Asn Pro Asp Trp Ala 
        675                 680                 685             


Ser Leu Asn Leu Gly Ala Leu Met Cys Ile Glu Cys Ser Gly Ile His 
    690                 695                 700                 


Arg His Leu Gly Ala His Leu Ser Arg Val Arg Ser Leu Asp Leu Asp 
705                 710                 715                 720 


Asp Trp Pro Pro Glu Leu Leu Ala Val Met Xaa Ala Met Gly Asn Ala 
                725                 730                 735     


Leu Ala Asn Ser Val Trp Glu Gly Ala Leu Gly Gly Tyr Ser Lys Pro 
            740                 745                 750         


Gly Pro Asp Ala Cys Arg Glu Glu Lys Glu Arg Trp Ile Arg Ala Lys 
        755                 760                 765             


Tyr Glu Gln Lys Leu Phe Leu Ala Pro Leu Pro Ser Ser Asp Val Pro 
    770                 775                 780                 


Leu Gly Gln Gln Leu Leu Arg Ala Val Val Glu Asp Asp Leu Arg Leu 
785                 790                 795                 800 


Leu Val Met Leu Leu Ala His Gly Ser Lys Glu Glu Val Asn Glu Xaa 
                805                 810                 815     


Tyr Gly Asp Gly Asp Gly Arg Xaa Ala Leu His Leu Ser Ser Ala Met 
            820                 825                 830         


Ala Asn Val Val Phe Xaa Gln Leu Leu Ile Trp Tyr Gly Val Asp Val 
        835                 840                 845             


Arg Ser Arg Asp Ala Arg Gly Leu Xaa Pro Leu Ala Tyr Ala Arg Arg 
    850                 855                 860                 


Ala Gly Ser Gln Glu Cys Ala Asp Ile Leu Ile Gln His Gly Cys Pro 
865                 870                 875                 880 


Gly Glu Gly Cys Gly Leu Ala Pro Xaa Pro Asn Arg Glu Pro Ala Asn 
                885                 890                 895     


Gly Xaa Asn Pro Ser Ala Glu Leu His Arg Ser Pro Ser Leu Leu 
            900                 905                 910     


<210> 1944
<211> 580
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<400> 1944
Met Val Leu Val Gly Xaa Gln Asp Ala Ile Ser Ala Ala Asn Pro Arg 
1               5                   10                  15      


Val Ile Asp Asp Ser Arg Ala Arg Lys Leu Ser Xaa Asp Leu Lys Arg 
            20                  25                  30          


Cys Xaa Tyr Tyr Glu Xaa Cys Ala Xaa Tyr Gly Leu Asn Val Glu Arg 
        35                  40                  45              


Val Phe Gln Asp Val Ala Gln Lys Val Val Ala Leu Arg Lys Lys Gln 
    50                  55                  60                  


Gln Leu Ala Ile Gly Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser His 
65                  70                  75                  80  


Ser Ala Val Ser Ala Ala Ser Ile Pro Ala Val His Ile Asn Gln Ala 
                85                  90                  95      


Xaa Asn Gly Gly Gly Ser Ala Phe Ser Asp Tyr Ser Ser Ser Val Pro 
            100                 105                 110         


Ser Xaa Pro Ser Ile Ser Gln Arg Glu Leu Arg Ile Glu Xaa Ile Ala 
        115                 120                 125             


Ala Ser Ser Xaa Pro Xaa Pro Ile Arg Lys Gln Ser Lys Arg Arg Ser 
    130                 135                 140                 


Asn Ile Phe Xaa Ser Arg Lys Gly Ala Asp Leu Asp Arg Glu Lys Lys 
145                 150                 155                 160 


Ala Ala Glu Cys Lys Val Asp Ser Ile Gly Ser Gly Arg Ala Ile Pro 
                165                 170                 175     


Ile Lys Gln Gly Ile Leu Leu Lys Arg Ser Gly Lys Ser Leu Asn Lys 
            180                 185                 190         


Glu Trp Lys Lys Lys Tyr Val Xaa Leu Cys Asp Asn Gly Leu Leu Xaa 
        195                 200                 205             


Tyr His Pro Ser Leu His Asp Tyr Met Gln Asn Ile His Gly Lys Glu 
    210                 215                 220                 


Ile Asp Leu Leu Arg Xaa Xaa Val Lys Val Pro Gly Lys Arg Leu Pro 
225                 230                 235                 240 


Arg Ala Xaa Pro Ala Xaa Ala Pro Gly Xaa Ser Pro Arg Ala Asn Gly 
                245                 250                 255     


Leu Ser Val Glu Arg Ser Asn Xaa Gln Leu Gly Gly Gly Xaa Glu Ala 
            260                 265                 270         


Glu Glu Ser Phe Glu Phe Val Val Val Ser Leu Xaa Gly Gln Xaa Trp 
        275                 280                 285             


His Phe Glu Ala Ser Xaa Ala Glu Glu Arg Glu Leu Trp Val Gln Ser 
    290                 295                 300                 


Val Gln Ala Gln Ile Leu Ala Ser Leu Gln Gly Cys Arg Ser Ala Lys 
305                 310                 315                 320 


Asp Lys Xaa Arg Leu Gly Asn Gln Asn Ala Ala Leu Ala Val Gln Ala 
                325                 330                 335     


Val Arg Xaa Val Arg Gly Asn Ser Phe Cys Ile Asp Cys Asp Ala Pro 
            340                 345                 350         


Asn Pro Asp Trp Ala Ser Leu Asn Leu Gly Ala Leu Met Cys Ile Glu 
        355                 360                 365             


Cys Ser Gly Ile His Arg His Leu Gly Ala His Leu Ser Arg Val Arg 
    370                 375                 380                 


Ser Leu Asp Leu Asp Asp Trp Pro Pro Glu Leu Leu Ala Val Met Xaa 
385                 390                 395                 400 


Ala Met Gly Asn Ala Leu Ala Asn Ser Val Trp Glu Gly Ala Leu Gly 
                405                 410                 415     


Gly Tyr Ser Lys Pro Gly Pro Asp Ala Cys Arg Glu Glu Lys Glu Arg 
            420                 425                 430         


Trp Ile Arg Ala Lys Tyr Glu Gln Lys Leu Phe Leu Ala Pro Leu Pro 
        435                 440                 445             


Ser Ser Asp Val Pro Leu Gly Gln Gln Leu Leu Arg Ala Val Val Glu 
    450                 455                 460                 


Asp Asp Leu Arg Leu Leu Val Met Leu Leu Ala His Gly Ser Lys Glu 
465                 470                 475                 480 


Glu Val Asn Glu Xaa Tyr Gly Asp Gly Asp Gly Arg Xaa Ala Leu His 
                485                 490                 495     


Leu Ser Ser Ala Met Ala Asn Val Val Phe Xaa Gln Leu Leu Ile Trp 
            500                 505                 510         


Tyr Gly Val Asp Val Arg Ser Arg Asp Ala Arg Gly Leu Xaa Pro Leu 
        515                 520                 525             


Ala Tyr Ala Arg Arg Ala Gly Ser Gln Glu Cys Ala Asp Ile Leu Ile 
    530                 535                 540                 


Gln His Gly Cys Pro Gly Glu Gly Cys Gly Leu Ala Pro Xaa Pro Asn 
545                 550                 555                 560 


Arg Glu Pro Ala Asn Gly Xaa Asn Pro Ser Ala Glu Leu His Arg Ser 
                565                 570                 575     


Pro Ser Leu Leu 
            580 


<210> 1945
<211> 194
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<400> 1945
Xaa Glu Gly Glu Arg Ser Arg Gly Leu Arg Glu Pro Gly Arg Ser Gly 
1               5                   10                  15      


Leu Ser Gly Ala Gly Arg Gly Leu His Arg Pro Cys Leu Ala Met Leu 
            20                  25                  30          


Ser Leu Ser Gly Val Leu Ala Arg Leu Arg Xaa Arg Pro Arg Asp Ser 
        35                  40                  45              


Phe Val Asn Ser Gln Glu Trp Xaa Leu Ser Arg Ser Val Pro Glu Leu 
    50                  55                  60                  


Lys Val Gly Ile Val Gly Asn Leu Ser Ser Gly Lys Ser Ala Leu Val 
65                  70                  75                  80  


His Arg Tyr Leu Xaa Gly Xaa Tyr Val Gln Glu Glu Ser Pro Glu Gly 
                85                  90                  95      


Gly Arg Phe Lys Lys Glu Ile Val Val Asp Gly Gln Ser Tyr Leu Leu 
            100                 105                 110         


Leu Ile Arg Asp Glu Gly Gly Pro Pro Glu Leu Gln Phe Ala Ala Trp 
        115                 120                 125             


Val Asp Ala Val Val Phe Val Phe Ser Leu Glu Asp Glu Ile Ser Phe 
    130                 135                 140                 


Gln Xaa Val Tyr Asn Tyr Phe Leu Arg Leu Cys Ser Phe Arg Asn Ala 
145                 150                 155                 160 


Ser Glu Val Pro Met Val Leu Val Gly Xaa Gln Asp Ala Ile Ser Ala 
                165                 170                 175     


Ala Asn Pro Arg Val Ile Asp Asp Ser Arg Ala Arg Lys Leu Ser Xaa 
            180                 185                 190         


Asp Leu 
        


<210> 1946
<211> 404
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<400> 1946
Xaa Glu Ile Asp Leu Leu Arg Xaa Xaa Val Lys Val Pro Gly Lys Arg 
1               5                   10                  15      


Leu Pro Arg Ala Xaa Pro Ala Xaa Ala Pro Gly Xaa Ser Pro Arg Ala 
            20                  25                  30          


Asn Gly Leu Ser Val Glu Arg Ser Asn Xaa Gln Leu Gly Gly Gly Xaa 
        35                  40                  45              


Ala Ser Gly Pro Ala Glu Val Leu Ser Ser Ser Pro Lys Leu Asp Pro 
    50                  55                  60                  


Pro Pro Ser Pro His Ser Asn Arg Lys Lys His Arg Arg Lys Lys Ser 
65                  70                  75                  80  


Xaa Gly Xaa Pro Arg Pro Asp Gly Pro Ser Ser Ala Xaa Glu Glu Ala 
                85                  90                  95      


Glu Glu Ser Phe Glu Phe Val Val Val Ser Leu Xaa Gly Gln Xaa Trp 
            100                 105                 110         


His Phe Glu Ala Ser Xaa Ala Glu Glu Arg Glu Leu Trp Val Gln Ser 
        115                 120                 125             


Val Gln Ala Gln Ile Leu Ala Ser Leu Gln Gly Cys Arg Ser Ala Lys 
    130                 135                 140                 


Asp Lys Xaa Arg Leu Gly Asn Gln Asn Ala Ala Leu Ala Val Gln Ala 
145                 150                 155                 160 


Val Arg Xaa Val Arg Gly Asn Ser Phe Cys Ile Asp Cys Asp Ala Pro 
                165                 170                 175     


Asn Pro Asp Trp Ala Ser Leu Asn Leu Gly Ala Leu Met Cys Ile Glu 
            180                 185                 190         


Cys Ser Gly Ile His Arg His Leu Gly Ala His Leu Ser Arg Val Arg 
        195                 200                 205             


Ser Leu Asp Leu Asp Asp Trp Pro Pro Glu Leu Leu Ala Val Met Xaa 
    210                 215                 220                 


Ala Met Gly Asn Ala Leu Ala Asn Ser Val Trp Glu Gly Ala Leu Gly 
225                 230                 235                 240 


Gly Tyr Ser Lys Pro Gly Pro Asp Ala Cys Arg Glu Glu Lys Glu Arg 
                245                 250                 255     


Trp Ile Arg Ala Lys Tyr Glu Gln Lys Leu Phe Leu Ala Pro Leu Pro 
            260                 265                 270         


Ser Ser Asp Val Pro Leu Gly Gln Gln Leu Leu Arg Ala Val Val Glu 
        275                 280                 285             


Asp Asp Leu Arg Leu Leu Val Met Leu Leu Ala His Gly Ser Lys Glu 
    290                 295                 300                 


Glu Val Asn Glu Xaa Tyr Gly Asp Gly Asp Gly Arg Xaa Ala Leu His 
305                 310                 315                 320 


Leu Ser Ser Ala Met Ala Asn Val Val Phe Xaa Gln Leu Leu Ile Trp 
                325                 330                 335     


Tyr Gly Val Asp Val Arg Ser Arg Asp Ala Arg Gly Leu Xaa Pro Leu 
            340                 345                 350         


Ala Tyr Ala Arg Arg Ala Gly Ser Gln Glu Cys Ala Asp Ile Leu Ile 
        355                 360                 365             


Gln His Gly Cys Pro Gly Glu Gly Cys Gly Leu Ala Pro Xaa Pro Asn 
    370                 375                 380                 


Arg Glu Pro Ala Asn Gly Xaa Asn Pro Ser Ala Glu Leu His Arg Ser 
385                 390                 395                 400 


Pro Ser Leu Leu 
                


<210> 1947
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<400> 1947
Xaa Met Val Leu Val Gly Xaa Gln Asp Ala Ile Ser Ala Ala Asn Pro 
1               5                   10                  15      


Arg Val Ile Asp Asp Ser Arg Ala Arg Lys Leu Ser Xaa Asp Leu Lys 
            20                  25                  30          


Arg Cys Xaa Tyr Tyr Glu Xaa Cys Ala Xaa Tyr Gly Leu Asn Val Glu 
        35                  40                  45              


Arg Val Phe Gln Asp Val Ala Gln Lys Val Val Ala Leu Arg Lys Lys 
    50                  55                  60                  


Gln Gln Leu Ala Ile Gly Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser 
65                  70                  75                  80  


His Ser Ala Val Ser Ala Ala Ser Ile Pro Ala Val His Ile Asn Gln 
                85                  90                  95      


Ala Xaa Asn Gly Gly Gly Ser Ala Phe Ser Asp Tyr Ser Ser Ser Val 
            100                 105                 110         


Pro Ser Xaa Pro Ser Ile Ser Gln Arg Glu Leu Arg Ile Glu Xaa Ile 
        115                 120                 125             


Ala Ala Ser Ser Xaa Pro Xaa Pro Ile Arg Lys Gln Ser Lys Arg Arg 
    130                 135                 140                 


Ser Asn Ile Phe Xaa Leu Met Asn Arg Arg Pro Glu Gly Cys Leu Pro 
145                 150                 155                 160 


Lys Ala Xaa Gln Arg Val Ser Trp Pro Ser 
                165                 170 


<210> 1948
<211> 342
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<400> 1948
Met Ala Ala Gly Xaa Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Xaa Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val 
    50                  55                  60                  


Leu Pro Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu 
65                  70                  75                  80  


Gly Ile Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Xaa Lys 
                85                  90                  95      


Ser Asn Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile 
            100                 105                 110         


Val Asp Ser Ala Ser Glu Leu Xaa Ala Gly Val Pro Asn Lys Val Gly 
        115                 120                 125             


Xaa Cys Val Ser Glu Gly Ser Tyr Pro Ala Gly Xaa Leu Ser Trp His 
    130                 135                 140                 


Leu Asp Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys 
145                 150                 155                 160 


Glu Gln Xaa Arg Arg His Pro Glu Xaa Gly Leu Phe Xaa Leu Gln Ser 
                165                 170                 175     


Glu Leu Met Val Xaa Pro Ala Arg Gly Gly Asp Pro Arg Pro Xaa Phe 
            180                 185                 190         


Ser Cys Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Xaa 
        195                 200                 205             


Ala Pro Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val 
    210                 215                 220                 


Gln Leu Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Xaa 
225                 230                 235                 240 


Val Xaa Leu Xaa Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His 
                245                 250                 255     


Trp Met Lys Asp Val Ser Asp Leu Glu Arg Gly Ala Gly Arg Xaa Arg 
            260                 265                 270         


Arg Gly Gly Ala Asn Cys Arg Leu Cys Gly Arg Ile Arg Ala Gly Asn 
        275                 280                 285             


Ser Ser Pro Gly Pro Gly Asp Pro Gly Arg Pro Gly Asp Ser Arg Pro 
    290                 295                 300                 


Ala His Trp Gly His Leu Val Ala Lys Ala Ala Xaa Pro Arg Arg Gly 
305                 310                 315                 320 


Glu Glu Gly Pro Arg Lys Pro Gly Gly Arg Gly Gly Ala Cys Arg Xaa 
                325                 330                 335     


Glu Ser Val Gly Gly Xaa 
            340         


<210> 1949
<211> 342
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<400> 1949
Met Ala Ala Gly Xaa Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Xaa Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val 
    50                  55                  60                  


Leu Pro Asn Ser Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu 
65                  70                  75                  80  


Gly Ile Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Xaa Lys 
                85                  90                  95      


Ser Asn Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile 
            100                 105                 110         


Val Asp Ser Ala Ser Glu Leu Xaa Ala Gly Val Pro Asn Lys Val Gly 
        115                 120                 125             


Xaa Cys Val Ser Glu Gly Ser Tyr Pro Ala Gly Xaa Leu Ser Trp His 
    130                 135                 140                 


Leu Asp Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys 
145                 150                 155                 160 


Glu Gln Xaa Arg Arg His Pro Glu Xaa Gly Leu Phe Xaa Leu Gln Ser 
                165                 170                 175     


Glu Leu Met Val Xaa Pro Ala Arg Gly Gly Asp Pro Arg Pro Xaa Phe 
            180                 185                 190         


Ser Cys Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Xaa 
        195                 200                 205             


Ala Pro Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val 
    210                 215                 220                 


Gln Leu Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Xaa 
225                 230                 235                 240 


Val Xaa Leu Xaa Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His 
                245                 250                 255     


Trp Met Lys Asp Val Ser Asp Leu Glu Arg Gly Ala Gly Arg Xaa Arg 
            260                 265                 270         


Arg Gly Gly Ala Asn Cys Arg Leu Cys Gly Arg Ile Arg Ala Gly Asn 
        275                 280                 285             


Ser Ser Pro Gly Pro Gly Asp Pro Gly Arg Pro Gly Asp Ser Arg Pro 
    290                 295                 300                 


Ala His Trp Gly His Leu Val Ala Lys Ala Ala Xaa Pro Arg Arg Gly 
305                 310                 315                 320 


Glu Glu Gly Pro Arg Lys Pro Gly Gly Arg Gly Gly Ala Cys Arg Xaa 
                325                 330                 335     


Glu Ser Val Gly Gly Xaa 
            340         


<210> 1950
<211> 234
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<400> 1950
Met Ala Ala Gly Xaa Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Xaa Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Xaa Gly Arg Xaa Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Xaa Lys Ser Asn 
            100                 105                 110         


Tyr Arg Ser Leu Arg Xaa Phe Xaa Ile Xaa Ala Ser Asp Trp Ile Phe 
        115                 120                 125             


Pro Pro Ser Glu Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser 
    130                 135                 140                 


Glu Leu Xaa Ala Gly Val Pro Asn Lys Val Gly Xaa Cys Val Ser Glu 
145                 150                 155                 160 


Gly Ser Tyr Pro Ala Gly Xaa Leu Ser Trp His Leu Asp Gly Lys Pro 
                165                 170                 175     


Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln Xaa Arg Arg 
            180                 185                 190         


His Pro Glu Xaa Gly Leu Phe Xaa Leu Gln Ser Glu Leu Met Val Xaa 
        195                 200                 205             


Pro Ala Arg Gly Gly Asp Pro Arg Pro Xaa Phe Ser Cys Ser Phe Ser 
    210                 215                 220                 


Pro Gly Leu Pro Arg His Arg Ala Leu Arg 
225                 230                 


<210> 1951
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<400> 1951
Met Ala Ala Gly Xaa Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Xaa Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Xaa Gly Arg Xaa Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Xaa Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Phe Glu Asn Leu His Asn Tyr Ser Leu 
        115                 120                 125             


<210> 1952
<211> 347
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<400> 1952
Met Ala Ala Gly Xaa Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Xaa Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Xaa Gly Arg Xaa Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Xaa Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Xaa Ala Gly Val Pro Asn Lys Val Gly Xaa Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Xaa Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Xaa Arg Arg His Pro Glu Xaa Gly Leu Phe Xaa Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Xaa Pro Ala Arg Gly Gly Asp Pro Arg Pro Xaa Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Xaa Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Xaa Val Xaa 
                245                 250                 255     


Leu Xaa Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Xaa Tyr Ser Cys Val Ala Xaa 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Xaa Ala Gly Glu Gly Phe Asp Lys 
                325                 330                 335     


Val Arg Glu Ala Glu Asp Ser Pro Gln His Met 
            340                 345         


<210> 1953
<211> 404
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<400> 1953
Met Ala Ala Gly Xaa Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Xaa Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Xaa Gly Arg Xaa Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Xaa Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Xaa Ala Gly Val Pro Asn Lys Val Gly Xaa Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Xaa Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Xaa Arg Arg His Pro Glu Xaa Gly Leu Phe Xaa Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Xaa Pro Ala Arg Gly Gly Asp Pro Arg Pro Xaa Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Xaa Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Xaa Val Xaa 
                245                 250                 255     


Leu Xaa Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Xaa Tyr Ser Cys Val Ala Xaa 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Xaa Ala Gly Ser Val Gly Gly Ser 
                325                 330                 335     


Gly Leu Gly Xaa Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly 
            340                 345                 350         


Xaa Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg 
        355                 360                 365             


Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
    370                 375                 380                 


Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser Ser 
385                 390                 395                 400 


Xaa Gly Gly Pro 
                


<210> 1954
<211> 233
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<400> 1954
Met Ala Ala Gly Xaa Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Xaa Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Xaa Gly Arg Xaa Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Xaa Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Xaa Ala Gly Val Pro Asn Lys Val Val Glu Glu 
    130                 135                 140                 


Ser Arg Arg Ser Arg Lys Arg Pro Cys Glu Gln Glu Val Gly Xaa Cys 
145                 150                 155                 160 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Xaa Leu Ser Trp His Leu Asp 
                165                 170                 175     


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
            180                 185                 190         


Xaa Arg Arg His Pro Glu Xaa Gly Leu Phe Xaa Leu Gln Ser Glu Leu 
        195                 200                 205             


Met Val Xaa Pro Ala Arg Gly Gly Asp Pro Arg Pro Xaa Phe Ser Cys 
    210                 215                 220                 


Ser Phe Ser Pro Gly Leu Pro Arg His 
225                 230             


<210> 1955
<211> 363
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<400> 1955
Met Ala Ala Gly Xaa Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Xaa Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Xaa Gly Arg Xaa Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Xaa Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Xaa Ala Gly Val Pro Asn Lys Val Val Glu Glu 
    130                 135                 140                 


Ser Arg Arg Ser Arg Lys Arg Pro Cys Glu Gln Glu Val Gly Xaa Cys 
145                 150                 155                 160 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Xaa Leu Ser Trp His Leu Asp 
                165                 170                 175     


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
            180                 185                 190         


Xaa Arg Arg His Pro Glu Xaa Gly Leu Phe Xaa Leu Gln Ser Glu Leu 
        195                 200                 205             


Met Val Xaa Pro Ala Arg Gly Gly Asp Pro Arg Pro Xaa Phe Ser Cys 
    210                 215                 220                 


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Xaa Ala Pro 
225                 230                 235                 240 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
                245                 250                 255     


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Xaa Val Xaa 
            260                 265                 270         


Leu Xaa Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
        275                 280                 285             


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
    290                 295                 300                 


Pro Glu Ile Gly Pro Gln Asp Gln Gly Xaa Tyr Ser Cys Val Ala Xaa 
305                 310                 315                 320 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
                325                 330                 335     


Ile Glu Pro Gly Glu Glu Gly Pro Xaa Ala Gly Glu Gly Phe Asp Lys 
            340                 345                 350         


Val Arg Glu Ala Glu Asp Ser Pro Gln His Met 
        355                 360             


<210> 1956
<211> 420
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<400> 1956
Met Ala Ala Gly Xaa Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Xaa Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Xaa Gly Arg Xaa Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Xaa Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Xaa Ala Gly Val Pro Asn Lys Val Val Glu Glu 
    130                 135                 140                 


Ser Arg Arg Ser Arg Lys Arg Pro Cys Glu Gln Glu Val Gly Xaa Cys 
145                 150                 155                 160 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Xaa Leu Ser Trp His Leu Asp 
                165                 170                 175     


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
            180                 185                 190         


Xaa Arg Arg His Pro Glu Xaa Gly Leu Phe Xaa Leu Gln Ser Glu Leu 
        195                 200                 205             


Met Val Xaa Pro Ala Arg Gly Gly Asp Pro Arg Pro Xaa Phe Ser Cys 
    210                 215                 220                 


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Xaa Ala Pro 
225                 230                 235                 240 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
                245                 250                 255     


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Xaa Val Xaa 
            260                 265                 270         


Leu Xaa Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
        275                 280                 285             


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
    290                 295                 300                 


Pro Glu Ile Gly Pro Gln Asp Gln Gly Xaa Tyr Ser Cys Val Ala Xaa 
305                 310                 315                 320 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
                325                 330                 335     


Ile Glu Pro Gly Glu Glu Gly Pro Xaa Ala Gly Ser Val Gly Gly Ser 
            340                 345                 350         


Gly Leu Gly Xaa Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly 
        355                 360                 365             


Xaa Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg 
    370                 375                 380                 


Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser Ser 
                405                 410                 415     


Xaa Gly Gly Pro 
            420 


<210> 1957
<211> 153
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 1957
Met Ala Ala Gly Xaa Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Xaa Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Xaa Gly Arg Xaa Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Leu Gly Gly Leu Gly Xaa Ala Ala Leu Leu Ile Gly Val Ile Leu Trp 
            100                 105                 110         


Gln Arg Arg Gln Arg Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln 
        115                 120                 125             


Glu Glu Glu Glu Glu Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu 
    130                 135                 140                 


Ala Gly Glu Ser Ser Xaa Gly Gly Pro 
145                 150             


<210> 1958
<211> 234
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<400> 1958
Met Ala Ala Gly Xaa Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Xaa Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Xaa Gly Arg Xaa Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Ser Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Xaa Lys Ser Asn 
            100                 105                 110         


Tyr Arg Ser Leu Arg Xaa Phe Xaa Ile Xaa Ala Ser Asp Trp Ile Phe 
        115                 120                 125             


Pro Pro Ser Glu Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser 
    130                 135                 140                 


Glu Leu Xaa Ala Gly Val Pro Asn Lys Val Gly Xaa Cys Val Ser Glu 
145                 150                 155                 160 


Gly Ser Tyr Pro Ala Gly Xaa Leu Ser Trp His Leu Asp Gly Lys Pro 
                165                 170                 175     


Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln Xaa Arg Arg 
            180                 185                 190         


His Pro Glu Xaa Gly Leu Phe Xaa Leu Gln Ser Glu Leu Met Val Xaa 
        195                 200                 205             


Pro Ala Arg Gly Gly Asp Pro Arg Pro Xaa Phe Ser Cys Ser Phe Ser 
    210                 215                 220                 


Pro Gly Leu Pro Arg His Arg Ala Leu Arg 
225                 230                 


<210> 1959
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<400> 1959
Met Ala Ala Gly Xaa Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Xaa Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Xaa Gly Arg Xaa Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Ser Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Xaa Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Phe Glu Asn Leu His Asn Tyr Ser Leu 
        115                 120                 125             


<210> 1960
<211> 347
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<400> 1960
Met Ala Ala Gly Xaa Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Xaa Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Xaa Gly Arg Xaa Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Ser Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Xaa Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Xaa Ala Gly Val Pro Asn Lys Val Gly Xaa Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Xaa Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Xaa Arg Arg His Pro Glu Xaa Gly Leu Phe Xaa Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Xaa Pro Ala Arg Gly Gly Asp Pro Arg Pro Xaa Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Xaa Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Xaa Val Xaa 
                245                 250                 255     


Leu Xaa Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Xaa Tyr Ser Cys Val Ala Xaa 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Xaa Ala Gly Glu Gly Phe Asp Lys 
                325                 330                 335     


Val Arg Glu Ala Glu Asp Ser Pro Gln His Met 
            340                 345         


<210> 1961
<211> 404
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<400> 1961
Met Ala Ala Gly Xaa Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Xaa Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Xaa Gly Arg Xaa Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Ser Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Xaa Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Xaa Ala Gly Val Pro Asn Lys Val Gly Xaa Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Xaa Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Xaa Arg Arg His Pro Glu Xaa Gly Leu Phe Xaa Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Xaa Pro Ala Arg Gly Gly Asp Pro Arg Pro Xaa Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Xaa Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Xaa Val Xaa 
                245                 250                 255     


Leu Xaa Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Xaa Tyr Ser Cys Val Ala Xaa 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Xaa Ala Gly Ser Val Gly Gly Ser 
                325                 330                 335     


Gly Leu Gly Xaa Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly 
            340                 345                 350         


Xaa Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg 
        355                 360                 365             


Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
    370                 375                 380                 


Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser Ser 
385                 390                 395                 400 


Xaa Gly Gly Pro 
                


<210> 1962
<211> 233
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<400> 1962
Met Ala Ala Gly Xaa Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Xaa Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Xaa Gly Arg Xaa Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Ser Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Xaa Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Xaa Ala Gly Val Pro Asn Lys Val Val Glu Glu 
    130                 135                 140                 


Ser Arg Arg Ser Arg Lys Arg Pro Cys Glu Gln Glu Val Gly Xaa Cys 
145                 150                 155                 160 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Xaa Leu Ser Trp His Leu Asp 
                165                 170                 175     


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
            180                 185                 190         


Xaa Arg Arg His Pro Glu Xaa Gly Leu Phe Xaa Leu Gln Ser Glu Leu 
        195                 200                 205             


Met Val Xaa Pro Ala Arg Gly Gly Asp Pro Arg Pro Xaa Phe Ser Cys 
    210                 215                 220                 


Ser Phe Ser Pro Gly Leu Pro Arg His 
225                 230             


<210> 1963
<211> 363
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<400> 1963
Met Ala Ala Gly Xaa Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Xaa Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Xaa Gly Arg Xaa Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Ser Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Xaa Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Xaa Ala Gly Val Pro Asn Lys Val Val Glu Glu 
    130                 135                 140                 


Ser Arg Arg Ser Arg Lys Arg Pro Cys Glu Gln Glu Val Gly Xaa Cys 
145                 150                 155                 160 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Xaa Leu Ser Trp His Leu Asp 
                165                 170                 175     


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
            180                 185                 190         


Xaa Arg Arg His Pro Glu Xaa Gly Leu Phe Xaa Leu Gln Ser Glu Leu 
        195                 200                 205             


Met Val Xaa Pro Ala Arg Gly Gly Asp Pro Arg Pro Xaa Phe Ser Cys 
    210                 215                 220                 


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Xaa Ala Pro 
225                 230                 235                 240 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
                245                 250                 255     


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Xaa Val Xaa 
            260                 265                 270         


Leu Xaa Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
        275                 280                 285             


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
    290                 295                 300                 


Pro Glu Ile Gly Pro Gln Asp Gln Gly Xaa Tyr Ser Cys Val Ala Xaa 
305                 310                 315                 320 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
                325                 330                 335     


Ile Glu Pro Gly Glu Glu Gly Pro Xaa Ala Gly Glu Gly Phe Asp Lys 
            340                 345                 350         


Val Arg Glu Ala Glu Asp Ser Pro Gln His Met 
        355                 360             


<210> 1964
<211> 420
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<400> 1964
Met Ala Ala Gly Xaa Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Xaa Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Xaa Gly Arg Xaa Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Ser Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Xaa Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Xaa Ala Gly Val Pro Asn Lys Val Val Glu Glu 
    130                 135                 140                 


Ser Arg Arg Ser Arg Lys Arg Pro Cys Glu Gln Glu Val Gly Xaa Cys 
145                 150                 155                 160 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Xaa Leu Ser Trp His Leu Asp 
                165                 170                 175     


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
            180                 185                 190         


Xaa Arg Arg His Pro Glu Xaa Gly Leu Phe Xaa Leu Gln Ser Glu Leu 
        195                 200                 205             


Met Val Xaa Pro Ala Arg Gly Gly Asp Pro Arg Pro Xaa Phe Ser Cys 
    210                 215                 220                 


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Xaa Ala Pro 
225                 230                 235                 240 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
                245                 250                 255     


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Xaa Val Xaa 
            260                 265                 270         


Leu Xaa Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
        275                 280                 285             


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
    290                 295                 300                 


Pro Glu Ile Gly Pro Gln Asp Gln Gly Xaa Tyr Ser Cys Val Ala Xaa 
305                 310                 315                 320 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
                325                 330                 335     


Ile Glu Pro Gly Glu Glu Gly Pro Xaa Ala Gly Ser Val Gly Gly Ser 
            340                 345                 350         


Gly Leu Gly Xaa Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly 
        355                 360                 365             


Xaa Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg 
    370                 375                 380                 


Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser Ser 
                405                 410                 415     


Xaa Gly Gly Pro 
            420 


<210> 1965
<211> 153
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 1965
Met Ala Ala Gly Xaa Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Xaa Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Xaa Gly Arg Xaa Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Ser Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Leu Gly Gly Leu Gly Xaa Ala Ala Leu Leu Ile Gly Val Ile Leu Trp 
            100                 105                 110         


Gln Arg Arg Gln Arg Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln 
        115                 120                 125             


Glu Glu Glu Glu Glu Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu 
    130                 135                 140                 


Ala Gly Glu Ser Ser Xaa Gly Gly Pro 
145                 150             


<210> 1966
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 1966
Met Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile 
1               5                   10                  15      


Leu Pro Glu Ile Gly Pro Gln Asp Gln Gly Xaa Tyr Ser Cys Val Ala 
            20                  25                  30          


Xaa His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser 
        35                  40                  45              


Ile Ile Glu Pro Gly Glu Glu Gly Pro Xaa Ala Gly Ser Val Gly Gly 
    50                  55                  60                  


Ser Gly Leu Gly Xaa Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu 
65                  70                  75                  80  


Gly Xaa Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln 
                85                  90                  95      


Arg Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu 
            100                 105                 110         


Glu Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser 
        115                 120                 125             


Ser Xaa Gly Gly Pro 
    130             


<210> 1967
<211> 294
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<400> 1967
Met Asn Arg Asn Gly Lys Glu Xaa Lys Ser Asn Tyr Arg Val Arg Val 
1               5                   10                  15      


Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu Leu 
            20                  25                  30          


Xaa Ala Gly Val Pro Asn Lys Val Gly Xaa Cys Val Ser Glu Gly Ser 
        35                  40                  45              


Tyr Pro Ala Gly Xaa Leu Ser Trp His Leu Asp Gly Lys Pro Leu Val 
    50                  55                  60                  


Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln Xaa Arg Arg His Pro 
65                  70                  75                  80  


Glu Xaa Gly Leu Phe Xaa Leu Gln Ser Glu Leu Met Val Xaa Pro Ala 
                85                  90                  95      


Arg Gly Gly Asp Pro Arg Pro Xaa Phe Ser Cys Ser Phe Ser Pro Gly 
            100                 105                 110         


Leu Pro Arg His Arg Ala Leu Arg Xaa Ala Pro Ile Gln Pro Arg Val 
        115                 120                 125             


Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu Val Val Glu Pro Glu 
    130                 135                 140                 


Gly Gly Ala Val Ala Pro Gly Gly Xaa Val Xaa Leu Xaa Cys Glu Val 
145                 150                 155                 160 


Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met Lys Asp Gly Val Pro 
                165                 170                 175     


Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu Pro Glu Ile Gly Pro 
            180                 185                 190         


Gln Asp Gln Gly Xaa Tyr Ser Cys Val Ala Xaa His Ser Ser His Gly 
        195                 200                 205             


Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile Ile Gly Ser Val Gly 
    210                 215                 220                 


Gly Ser Gly Leu Gly Xaa Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly 
225                 230                 235                 240 


Leu Gly Xaa Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg 
                245                 250                 255     


Gln Arg Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu 
            260                 265                 270         


Glu Glu Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu 
        275                 280                 285             


Ser Ser Xaa Gly Gly Pro 
    290                 


<210> 1968
<211> 857
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<400> 1968
Met Glu Ala Gly Pro Ser Gly Ala Ala Ala Gly Ala Tyr Leu Pro Pro 
1               5                   10                  15      


Leu Gln Gln Val Phe Gln Ala Pro Arg Arg Pro Gly Ile Gly Xaa Val 
            20                  25                  30          


Gly Lys Pro Ile Lys Leu Leu Ala Asn Tyr Phe Glu Val Asp Ile Pro 
        35                  40                  45              


Lys Ile Asp Val Tyr His Tyr Glu Val Asp Ile Lys Pro Asp Lys Cys 
    50                  55                  60                  


Pro Arg Arg Val Asn Arg Glu Val Val Glu Tyr Met Val Gln His Phe 
65                  70                  75                  80  


Lys Pro Gln Ile Phe Gly Asp Arg Lys Pro Val Tyr Asp Gly Lys Lys 
                85                  90                  95      


Asn Ile Tyr Xaa Val Xaa Ala Leu Pro Ile Gly Asn Glu Arg Val Asp 
            100                 105                 110         


Phe Glu Val Xaa Ile Pro Gly Glu Gly Lys Asp Arg Ile Phe Lys Val 
        115                 120                 125             


Ser Ile Lys Trp Leu Ala Ile Val Ser Trp Arg Met Leu His Glu Ala 
    130                 135                 140                 


Leu Val Ser Gly Gln Ile Pro Val Pro Leu Glu Ser Val Gln Ala Leu 
145                 150                 155                 160 


Asp Val Ala Met Arg His Leu Ala Ser Met Arg Tyr Xaa Pro Val Gly 
                165                 170                 175     


Arg Ser Phe Phe Ser Pro Pro Glu Gly Tyr Tyr His Pro Leu Gly Gly 
            180                 185                 190         


Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser Val Arg Pro Ala Met 
        195                 200                 205             


Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala Xaa Ala Phe Tyr Lys 
    210                 215                 220                 


Ala Gln Pro Val Ile Glu Phe Met Cys Glu Val Leu Asp Ile Arg Asn 
225                 230                 235                 240 


Ile Asp Glu Gln Pro Lys Pro Leu Xaa Asp Ser Gln Arg Val Arg Phe 
                245                 250                 255     


Xaa Lys Glu Ile Lys Gly Leu Lys Val Glu Val Xaa His Cys Gly Gln 
            260                 265                 270         


Met Lys Arg Lys Tyr Arg Val Cys Asn Val Xaa Arg Arg Pro Ala Ser 
        275                 280                 285             


His Gln Xaa Phe Pro Leu Gln Leu Glu Ser Gly Gln Xaa Val Glu Cys 
    290                 295                 300                 


Xaa Val Ala Gln Tyr Phe Lys Gln Lys Tyr Asn Leu Gln Leu Lys Tyr 
305                 310                 315                 320 


Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu Gln Lys His Xaa Tyr 
                325                 330                 335     


Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly Gln Arg Cys Ile Lys 
            340                 345                 350         


Lys Leu Xaa Asp Asn Gln Xaa Ser Xaa Met Ile Lys Ala Xaa Ala Arg 
        355                 360                 365             


Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Arg Leu Met Lys Asn Ala 
    370                 375                 380                 


Ser Tyr Asn Leu Asp Pro Tyr Ile Gln Glu Phe Gly Ile Lys Val Lys 
385                 390                 395                 400 


Asp Asp Met Xaa Glu Val Xaa Gly Arg Val Leu Pro Ala Pro Ile Leu 
                405                 410                 415     


Gln Tyr Gly Gly Arg Asn Arg Ala Ile Ala Xaa Pro Asn Gln Gly Val 
            420                 425                 430         


Trp Asp Met Arg Gly Lys Gln Phe Tyr Asn Gly Ile Glu Ile Lys Val 
        435                 440                 445             


Trp Ala Ile Ala Cys Phe Ala Pro Gln Lys Gln Cys Arg Glu Glu Val 
    450                 455                 460                 


Leu Lys Asn Phe Xaa Asp Gln Leu Arg Lys Ile Ser Lys Asp Ala Gly 
465                 470                 475                 480 


Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys Tyr Ala Gln Gly Ala 
                485                 490                 495     


Asp Ser Val Glu Pro Met Phe Arg His Leu Lys Asn Xaa Tyr Ser Gly 
            500                 505                 510         


Leu Gln Leu Ile Ile Val Ile Leu Pro Gly Lys Xaa Pro Val Tyr Ala 
        515                 520                 525             


Glu Val Lys Arg Val Gly Asp Xaa Leu Leu Gly Met Ala Xaa Gln Cys 
    530                 535                 540                 


Val Gln Val Lys Asn Val Val Lys Xaa Ser Pro Gln Xaa Leu Ser Asn 
545                 550                 555                 560 


Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly Ile Asn Asn Ile Leu 
                565                 570                 575     


Val Pro His Gln Arg Ser Ala Val Phe Gln Gln Pro Val Ile Phe Leu 
            580                 585                 590         


Gly Ala Asp Val Xaa His Pro Pro Ala Gly Asp Gly Lys Lys Pro Ser 
        595                 600                 605             


Ile Xaa Ala Val Val Gly Ser Met Asp Ala His Pro Ser Arg Tyr Cys 
    610                 615                 620                 


Ala Xaa Val Arg Val Gln Arg Pro Arg Gln Glu Ile Ile Glu Asp Leu 
625                 630                 635                 640 


Ser Tyr Met Val Arg Glu Leu Leu Ile Gln Phe Tyr Lys Ser Xaa Arg 
                645                 650                 655     


Phe Lys Pro Xaa Arg Ile Ile Phe Tyr Arg Asp Gly Val Pro Glu Gly 
            660                 665                 670         


Gln Leu Pro Gln Ile Leu His Tyr Glu Leu Leu Ala Ile Arg Asp Ala 
        675                 680                 685             


Cys Ile Lys Leu Glu Lys Asp Tyr Gln Pro Gly Ile Xaa Tyr Ile Val 
    690                 695                 700                 


Val Gln Lys Arg His His Xaa Arg Leu Phe Cys Ala Asp Lys Asn Glu 
705                 710                 715                 720 


Arg Ile Gly Lys Ser Gly Asn Ile Pro Ala Gly Xaa Xaa Val Asp Xaa 
                725                 730                 735     


Asn Ile Xaa His Pro Phe Glu Phe Asp Phe Tyr Leu Cys Ser His Ala 
            740                 745                 750         


Gly Ile Gln Gly Xaa Ser Arg Pro Ser His Tyr Tyr Val Leu Trp Asp 
        755                 760                 765             


Asp Asn Arg Phe Xaa Ala Asp Glu Leu Gln Ile Leu Xaa Tyr Gln Leu 
    770                 775                 780                 


Cys His Xaa Tyr Val Arg Cys Xaa Arg Ser Val Ser Ile Pro Ala Pro 
785                 790                 795                 800 


Ala Tyr Tyr Ala Arg Leu Val Ala Phe Arg Ala Arg Tyr His Leu Val 
                805                 810                 815     


Asp Lys Glu His Asp Ser Gly Glu Gly Ser His Ile Ser Gly Gln Ser 
            820                 825                 830         


Asn Gly Arg Asp Pro Gln Ala Leu Ala Lys Ala Val Gln Val His Gln 
        835                 840                 845             


Asp Xaa Leu Arg Xaa Met Tyr Phe Ala 
    850                 855         


<210> 1969
<211> 782
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<400> 1969
Met Val Gln His Phe Lys Pro Gln Ile Phe Gly Asp Arg Lys Pro Val 
1               5                   10                  15      


Tyr Asp Gly Lys Lys Asn Ile Tyr Xaa Val Xaa Ala Leu Pro Ile Gly 
            20                  25                  30          


Asn Glu Arg Val Asp Phe Glu Val Xaa Ile Pro Gly Glu Gly Lys Asp 
        35                  40                  45              


Arg Ile Phe Lys Val Ser Ile Lys Trp Leu Ala Ile Val Ser Trp Arg 
    50                  55                  60                  


Met Leu His Glu Ala Leu Val Ser Gly Gln Ile Pro Val Pro Leu Glu 
65                  70                  75                  80  


Ser Val Gln Ala Leu Asp Val Ala Met Arg His Leu Ala Ser Met Arg 
                85                  90                  95      


Tyr Xaa Pro Val Gly Arg Ser Phe Phe Ser Pro Pro Glu Gly Tyr Tyr 
            100                 105                 110         


His Pro Leu Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser 
        115                 120                 125             


Val Arg Pro Ala Met Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala 
    130                 135                 140                 


Xaa Ala Phe Tyr Lys Ala Gln Pro Val Ile Glu Phe Met Cys Glu Val 
145                 150                 155                 160 


Leu Asp Ile Arg Asn Ile Asp Glu Gln Pro Lys Pro Leu Xaa Asp Ser 
                165                 170                 175     


Gln Arg Val Arg Phe Xaa Lys Glu Ile Lys Gly Leu Lys Val Glu Val 
            180                 185                 190         


Xaa His Cys Gly Gln Met Lys Arg Lys Tyr Arg Val Cys Asn Val Xaa 
        195                 200                 205             


Arg Arg Pro Ala Ser His Gln Xaa Phe Pro Leu Gln Leu Glu Ser Gly 
    210                 215                 220                 


Gln Xaa Val Glu Cys Xaa Val Ala Gln Tyr Phe Lys Gln Lys Tyr Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Tyr Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu 
                245                 250                 255     


Gln Lys His Xaa Tyr Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly 
            260                 265                 270         


Gln Arg Cys Ile Lys Lys Leu Xaa Asp Asn Gln Xaa Ser Xaa Met Ile 
        275                 280                 285             


Lys Ala Xaa Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Arg 
    290                 295                 300                 


Leu Met Lys Asn Ala Ser Tyr Asn Leu Asp Pro Tyr Ile Gln Glu Phe 
305                 310                 315                 320 


Gly Ile Lys Val Lys Asp Asp Met Xaa Glu Val Xaa Gly Arg Val Leu 
                325                 330                 335     


Pro Ala Pro Ile Leu Gln Tyr Gly Gly Arg Asn Arg Ala Ile Ala Xaa 
            340                 345                 350         


Pro Asn Gln Gly Val Trp Asp Met Arg Gly Lys Gln Phe Tyr Asn Gly 
        355                 360                 365             


Ile Glu Ile Lys Val Trp Ala Ile Ala Cys Phe Ala Pro Gln Lys Gln 
    370                 375                 380                 


Cys Arg Glu Glu Val Leu Lys Asn Phe Xaa Asp Gln Leu Arg Lys Ile 
385                 390                 395                 400 


Ser Lys Asp Ala Gly Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys 
                405                 410                 415     


Tyr Ala Gln Gly Ala Asp Ser Val Glu Pro Met Phe Arg His Leu Lys 
            420                 425                 430         


Asn Xaa Tyr Ser Gly Leu Gln Leu Ile Ile Val Ile Leu Pro Gly Lys 
        435                 440                 445             


Xaa Pro Val Tyr Ala Glu Val Lys Arg Val Gly Asp Xaa Leu Leu Gly 
    450                 455                 460                 


Met Ala Xaa Gln Cys Val Gln Val Lys Asn Val Val Lys Xaa Ser Pro 
465                 470                 475                 480 


Gln Xaa Leu Ser Asn Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly 
                485                 490                 495     


Ile Asn Asn Ile Leu Val Pro His Gln Arg Ser Ala Val Phe Gln Gln 
            500                 505                 510         


Pro Val Ile Phe Leu Gly Ala Asp Val Xaa His Pro Pro Ala Gly Asp 
        515                 520                 525             


Gly Lys Lys Pro Ser Ile Xaa Ala Val Val Gly Ser Met Asp Ala His 
    530                 535                 540                 


Pro Ser Arg Tyr Cys Ala Xaa Val Arg Val Gln Arg Pro Arg Gln Glu 
545                 550                 555                 560 


Ile Ile Glu Asp Leu Ser Tyr Met Val Arg Glu Leu Leu Ile Gln Phe 
                565                 570                 575     


Tyr Lys Ser Xaa Arg Phe Lys Pro Xaa Arg Ile Ile Phe Tyr Arg Asp 
            580                 585                 590         


Gly Val Pro Glu Gly Gln Leu Pro Gln Ile Leu His Tyr Glu Leu Leu 
        595                 600                 605             


Ala Ile Arg Asp Ala Cys Ile Lys Leu Glu Lys Asp Tyr Gln Pro Gly 
    610                 615                 620                 


Ile Xaa Tyr Ile Val Val Gln Lys Arg His His Xaa Arg Leu Phe Cys 
625                 630                 635                 640 


Ala Asp Lys Asn Glu Arg Ile Gly Lys Ser Gly Asn Ile Pro Ala Gly 
                645                 650                 655     


Xaa Xaa Val Asp Xaa Asn Ile Xaa His Pro Phe Glu Phe Asp Phe Tyr 
            660                 665                 670         


Leu Cys Ser His Ala Gly Ile Gln Gly Xaa Ser Arg Pro Ser His Tyr 
        675                 680                 685             


Tyr Val Leu Trp Asp Asp Asn Arg Phe Xaa Ala Asp Glu Leu Gln Ile 
    690                 695                 700                 


Leu Xaa Tyr Gln Leu Cys His Xaa Tyr Val Arg Cys Xaa Arg Ser Val 
705                 710                 715                 720 


Ser Ile Pro Ala Pro Ala Tyr Tyr Ala Arg Leu Val Ala Phe Arg Ala 
                725                 730                 735     


Arg Tyr His Leu Val Asp Lys Glu His Asp Ser Gly Glu Gly Ser His 
            740                 745                 750         


Ile Ser Gly Gln Ser Asn Gly Arg Asp Pro Gln Ala Leu Ala Lys Ala 
        755                 760                 765             


Val Gln Val His Gln Asp Xaa Leu Arg Xaa Met Tyr Phe Ala 
    770                 775                 780         


<210> 1970
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<400> 1970
Xaa His Phe Lys Pro Gln Ile Phe Gly Asp Arg Lys Pro Val Tyr Asp 
1               5                   10                  15      


Gly Lys Lys Asn Ile Tyr Xaa Val Xaa Ala Leu Pro Ile Gly Asn Glu 
            20                  25                  30          


Arg Val Asp Phe Glu Val Xaa Ile Pro Gly Glu Gly Lys Asp Arg Ile 
        35                  40                  45              


Phe Lys Val Ser Ile Lys Trp Leu Ala Ile Val Ser Trp Arg Met Leu 
    50                  55                  60                  


His Glu Ala Leu Val Ser Gly Gln Ile Pro Val Pro Leu Glu Ser Val 
65                  70                  75                  80  


Gln Ala Leu Asp Val Ala Met Arg His Leu Ala Ser Met Arg Pro Gly 
                85                  90                  95      


Leu Leu Arg Ala Gln Asp Ala Ser Gln Gly Gly Gly Leu Cys Pro Arg 
            100                 105                 110         


Asp Gln Phe Ser Ala Cys Pro Cys Gln Val His Pro Cys Gly Pro Leu 
        115                 120                 125             


Leu Leu Leu Xaa Ala 
    130             


<210> 1971
<211> 36
<212> PRT
<213> Homo sapiens

<400> 1971
Met Asp Ile Pro Lys Ile Asp Ile Tyr His Tyr Glu Leu Asp Ile Lys 
1               5                   10                  15      


Pro Glu Lys Cys Pro Arg Arg Val Asn Arg Glu Ile Val Glu His Met 
            20                  25                  30          


Val Gln His Phe 
        35      


<210> 1972
<211> 825
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<400> 1972
Met Tyr Ser Gly Ala Gly Pro Ala Leu Ala Pro Pro Ala Pro Pro Pro 
1               5                   10                  15      


Pro Ile Gln Gly Tyr Ala Phe Lys Pro Pro Pro Arg Pro Asp Phe Gly 
            20                  25                  30          


Xaa Ser Gly Arg Xaa Ile Lys Leu Gln Ala Asn Phe Phe Glu Met Asp 
        35                  40                  45              


Ile Pro Lys Ile Asp Ile Tyr His Tyr Glu Leu Asp Ile Lys Pro Glu 
    50                  55                  60                  


Lys Cys Pro Arg Arg Val Asn Arg Glu Ile Val Glu His Met Val Gln 
65                  70                  75                  80  


His Phe Lys Xaa Gln Ile Phe Gly Asp Arg Lys Pro Val Phe Asp Gly 
                85                  90                  95      


Arg Lys Asn Leu Tyr Xaa Ala Met Pro Leu Pro Ile Gly Arg Asp Lys 
            100                 105                 110         


Val Glu Leu Glu Val Xaa Leu Pro Gly Glu Gly Lys Asp Arg Ile Phe 
        115                 120                 125             


Lys Val Ser Ile Lys Trp Val Ser Cys Val Ser Leu Gln Ala Leu His 
    130                 135                 140                 


Asp Ala Leu Ser Gly Arg Leu Pro Ser Val Pro Phe Glu Xaa Ile Gln 
145                 150                 155                 160 


Ala Leu Asp Val Val Met Arg His Leu Pro Ser Met Arg Tyr Xaa Pro 
                165                 170                 175     


Val Gly Arg Ser Phe Phe Xaa Ala Ser Glu Gly Cys Ser Asn Pro Leu 
            180                 185                 190         


Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser Val Arg Pro 
        195                 200                 205             


Ser Leu Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala Xaa Ala Phe 
    210                 215                 220                 


Tyr Lys Ala Gln Pro Val Ile Glu Phe Val Cys Glu Val Leu Asp Phe 
225                 230                 235                 240 


Lys Ser Ile Glu Glu Gln Gln Lys Pro Leu Xaa Asp Ser Gln Arg Val 
                245                 250                 255     


Lys Phe Xaa Lys Glu Ile Lys Gly Leu Lys Val Glu Ile Xaa His Cys 
            260                 265                 270         


Gly Gln Met Lys Arg Lys Tyr Arg Val Cys Asn Val Xaa Arg Arg Pro 
        275                 280                 285             


Ala Ser His Gln Xaa Phe Pro Leu Gln Gln Glu Ser Gly Gln Xaa Val 
    290                 295                 300                 


Glu Cys Xaa Val Ala Gln Tyr Phe Lys Asp Arg His Lys Leu Val Leu 
305                 310                 315                 320 


Arg Tyr Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu Gln Lys His 
                325                 330                 335     


Xaa Tyr Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly Gln Arg Cys 
            340                 345                 350         


Ile Lys Lys Leu Xaa Asp Asn Gln Xaa Ser Xaa Met Ile Arg Ala Xaa 
        355                 360                 365             


Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Lys Leu Met Arg 
    370                 375                 380                 


Ser Ala Ser Phe Asn Xaa Asp Pro Tyr Val Arg Glu Phe Gly Ile Met 
385                 390                 395                 400 


Val Lys Asp Glu Met Xaa Asp Val Xaa Gly Arg Val Leu Gln Pro Pro 
                405                 410                 415     


Ser Ile Leu Tyr Gly Gly Arg Asn Lys Ala Ile Ala Xaa Pro Val Gln 
            420                 425                 430         


Gly Val Trp Asp Met Arg Asn Lys Gln Phe His Xaa Gly Ile Glu Ile 
        435                 440                 445             


Lys Val Trp Ala Ile Ala Cys Phe Ala Pro Gln Arg Gln Cys Xaa Glu 
    450                 455                 460                 


Val His Leu Lys Ser Phe Xaa Glu Gln Leu Arg Lys Ile Ser Arg Asp 
465                 470                 475                 480 


Ala Gly Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys Tyr Ala Gln 
                485                 490                 495     


Gly Ala Asp Ser Val Glu Pro Met Phe Arg His Leu Lys Asn Xaa Tyr 
            500                 505                 510         


Ala Gly Leu Gln Leu Val Val Val Ile Leu Pro Gly Lys Xaa Pro Val 
        515                 520                 525             


Tyr Ala Glu Val Lys Arg Val Gly Asp Xaa Val Leu Gly Met Ala Xaa 
    530                 535                 540                 


Gln Cys Val Gln Met Lys Asn Val Gln Arg Xaa Xaa Pro Gln Xaa Leu 
545                 550                 555                 560 


Ser Asn Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly Val Asn Asn 
                565                 570                 575     


Ile Leu Leu Pro Gln Gly Arg Pro Pro Val Phe Gln Gln Pro Val Ile 
            580                 585                 590         


Phe Leu Gly Ala Asp Val Xaa His Pro Pro Ala Gly Asp Gly Lys Lys 
        595                 600                 605             


Pro Ser Ile Ala Ala Val Val Gly Ser Met Asp Ala His Pro Asn Arg 
    610                 615                 620                 


Tyr Cys Ala Xaa Val Arg Val Gln Gln His Arg Gln Glu Ile Ile Gln 
625                 630                 635                 640 


Asp Leu Ala Ala Met Val Arg Glu Leu Leu Ile Gln Phe Tyr Lys Ser 
                645                 650                 655     


Xaa Arg Phe Lys Pro Xaa Arg Ile Ile Phe Tyr Arg Asp Gly Val Ser 
            660                 665                 670         


Glu Gly Gln Phe Gln Gln Val Leu His His Glu Leu Leu Ala Ile Arg 
        675                 680                 685             


Glu Ala Cys Ile Lys Leu Glu Lys Asp Tyr Gln Pro Gly Ile Xaa Phe 
    690                 695                 700                 


Ile Val Val Gln Lys Arg His His Xaa Arg Leu Phe Cys Xaa Asp Lys 
705                 710                 715                 720 


Asn Glu Arg Gly Xaa Ser Arg Pro Ser His Tyr His Val Leu Trp Asp 
                725                 730                 735     


Asp Asn Arg Phe Ser Ser Asp Glu Leu Gln Ile Leu Xaa Tyr Gln Leu 
            740                 745                 750         


Cys His Xaa Tyr Val Arg Cys Xaa Arg Ser Val Ser Ile Pro Ala Pro 
        755                 760                 765             


Ala Tyr Tyr Ala His Leu Val Ala Phe Arg Ala Arg Tyr His Leu Val 
    770                 775                 780                 


Asp Lys Glu His Asp Ser Ala Glu Gly Ser His Xaa Ser Gly Gln Ser 
785                 790                 795                 800 


Asn Gly Arg Asp His Gln Ala Leu Ala Lys Ala Val Gln Val His Gln 
                805                 810                 815     


Asp Xaa Leu Arg Xaa Met Tyr Phe Ala 
            820                 825 


<210> 1973
<211> 859
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<400> 1973
Met Tyr Ser Gly Ala Gly Pro Ala Leu Ala Pro Pro Ala Pro Pro Pro 
1               5                   10                  15      


Pro Ile Gln Gly Tyr Ala Phe Lys Pro Pro Pro Arg Pro Asp Phe Gly 
            20                  25                  30          


Xaa Ser Gly Arg Xaa Ile Lys Leu Gln Ala Asn Phe Phe Glu Met Asp 
        35                  40                  45              


Ile Pro Lys Ile Asp Ile Tyr His Tyr Glu Leu Asp Ile Lys Pro Glu 
    50                  55                  60                  


Lys Cys Pro Arg Arg Val Asn Arg Glu Ile Val Glu His Met Val Gln 
65                  70                  75                  80  


His Phe Lys Xaa Gln Ile Phe Gly Asp Arg Lys Pro Val Phe Asp Gly 
                85                  90                  95      


Arg Lys Asn Leu Tyr Xaa Ala Met Pro Leu Pro Ile Gly Arg Asp Lys 
            100                 105                 110         


Val Glu Leu Glu Val Xaa Leu Pro Gly Glu Gly Lys Asp Arg Ile Phe 
        115                 120                 125             


Lys Val Ser Ile Lys Trp Val Ser Cys Val Ser Leu Gln Ala Leu His 
    130                 135                 140                 


Asp Ala Leu Ser Gly Arg Leu Pro Ser Val Pro Phe Glu Xaa Ile Gln 
145                 150                 155                 160 


Ala Leu Asp Val Val Met Arg His Leu Pro Ser Met Arg Tyr Xaa Pro 
                165                 170                 175     


Val Gly Arg Ser Phe Phe Xaa Ala Ser Glu Gly Cys Ser Asn Pro Leu 
            180                 185                 190         


Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser Val Arg Pro 
        195                 200                 205             


Ser Leu Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala Xaa Ala Phe 
    210                 215                 220                 


Tyr Lys Ala Gln Pro Val Ile Glu Phe Val Cys Glu Val Leu Asp Phe 
225                 230                 235                 240 


Lys Ser Ile Glu Glu Gln Gln Lys Pro Leu Xaa Asp Ser Gln Arg Val 
                245                 250                 255     


Lys Phe Xaa Lys Glu Ile Lys Gly Leu Lys Val Glu Ile Xaa His Cys 
            260                 265                 270         


Gly Gln Met Lys Arg Lys Tyr Arg Val Cys Asn Val Xaa Arg Arg Pro 
        275                 280                 285             


Ala Ser His Gln Xaa Phe Pro Leu Gln Gln Glu Ser Gly Gln Xaa Val 
    290                 295                 300                 


Glu Cys Xaa Val Ala Gln Tyr Phe Lys Asp Arg His Lys Leu Val Leu 
305                 310                 315                 320 


Arg Tyr Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu Gln Lys His 
                325                 330                 335     


Xaa Tyr Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly Gln Arg Cys 
            340                 345                 350         


Ile Lys Lys Leu Xaa Asp Asn Gln Xaa Ser Xaa Met Ile Arg Ala Xaa 
        355                 360                 365             


Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Lys Leu Met Arg 
    370                 375                 380                 


Ser Ala Ser Phe Asn Xaa Asp Pro Tyr Val Arg Glu Phe Gly Ile Met 
385                 390                 395                 400 


Val Lys Asp Glu Met Xaa Asp Val Xaa Gly Arg Val Leu Gln Pro Pro 
                405                 410                 415     


Ser Ile Leu Tyr Gly Gly Arg Asn Lys Ala Ile Ala Xaa Pro Val Gln 
            420                 425                 430         


Gly Val Trp Asp Met Arg Asn Lys Gln Phe His Xaa Gly Ile Glu Ile 
        435                 440                 445             


Lys Val Trp Ala Ile Ala Cys Phe Ala Pro Gln Arg Gln Cys Xaa Glu 
    450                 455                 460                 


Val His Leu Lys Ser Phe Xaa Glu Gln Leu Arg Lys Ile Ser Arg Asp 
465                 470                 475                 480 


Ala Gly Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys Tyr Ala Gln 
                485                 490                 495     


Gly Ala Asp Ser Val Glu Pro Met Phe Arg His Leu Lys Asn Xaa Tyr 
            500                 505                 510         


Ala Gly Leu Gln Leu Val Val Val Ile Leu Pro Gly Lys Xaa Pro Val 
        515                 520                 525             


Tyr Ala Glu Val Lys Arg Val Gly Asp Xaa Val Leu Gly Met Ala Xaa 
    530                 535                 540                 


Gln Cys Val Gln Met Lys Asn Val Gln Arg Xaa Xaa Pro Gln Xaa Leu 
545                 550                 555                 560 


Ser Asn Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly Val Asn Asn 
                565                 570                 575     


Ile Leu Leu Pro Gln Gly Arg Pro Pro Val Phe Gln Gln Pro Val Ile 
            580                 585                 590         


Phe Leu Gly Ala Asp Val Xaa His Pro Pro Ala Gly Asp Gly Lys Lys 
        595                 600                 605             


Pro Ser Ile Ala Ala Val Val Gly Ser Met Asp Ala His Pro Asn Arg 
    610                 615                 620                 


Tyr Cys Ala Xaa Val Arg Val Gln Gln His Arg Gln Glu Ile Ile Gln 
625                 630                 635                 640 


Asp Leu Ala Ala Met Val Arg Glu Leu Leu Ile Gln Phe Tyr Lys Ser 
                645                 650                 655     


Xaa Arg Phe Lys Pro Xaa Arg Ile Ile Phe Tyr Arg Asp Gly Val Ser 
            660                 665                 670         


Glu Gly Gln Phe Gln Gln Val Leu His His Glu Leu Leu Ala Ile Arg 
        675                 680                 685             


Glu Ala Cys Ile Lys Leu Glu Lys Asp Tyr Gln Pro Gly Ile Xaa Phe 
    690                 695                 700                 


Ile Val Val Gln Lys Arg His His Xaa Arg Leu Phe Cys Xaa Asp Lys 
705                 710                 715                 720 


Asn Glu Arg Val Gly Lys Ser Gly Asn Ile Pro Ala Gly Xaa Xaa Val 
                725                 730                 735     


Asp Xaa Lys Ile Xaa His Pro Xaa Glu Phe Asp Phe Tyr Leu Cys Ser 
            740                 745                 750         


His Ala Gly Ile Gln Gly Xaa Ser Arg Pro Ser His Tyr His Val Leu 
        755                 760                 765             


Trp Asp Asp Asn Arg Phe Ser Ser Asp Glu Leu Gln Ile Leu Xaa Tyr 
    770                 775                 780                 


Gln Leu Cys His Xaa Tyr Val Arg Cys Xaa Arg Ser Val Ser Ile Pro 
785                 790                 795                 800 


Ala Pro Ala Tyr Tyr Ala His Leu Val Ala Phe Arg Ala Arg Tyr His 
                805                 810                 815     


Leu Val Asp Lys Glu His Asp Ser Ala Glu Gly Ser His Xaa Ser Gly 
            820                 825                 830         


Gln Ser Asn Gly Arg Asp His Gln Ala Leu Ala Lys Ala Val Gln Val 
        835                 840                 845             


His Gln Asp Xaa Leu Arg Xaa Met Tyr Phe Ala 
    850                 855                 


<210> 1974
<211> 73
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<400> 1974
Met Tyr Ser Gly Ala Gly Pro Gly Lys Ser Trp Asn Xaa Trp Ser Ser 
1               5                   10                  15      


Xaa Leu Lys His Arg Ser Leu Gly Ile Gly Ser Pro Cys Leu Xaa Ala 
            20                  25                  30          


Gly Arg Ile Tyr Xaa Gln Pro Cys Pro Phe Arg Leu Gly Gly Xaa Arg 
        35                  40                  45              


Trp Ser Trp Arg Ser Arg Cys Gln Glu Lys Ala Arg Ile Ala Ser Ser 
    50                  55                  60                  


Arg Cys Pro Ser Ser Gly Cys Pro Ala 
65                  70              


<210> 1975
<211> 626
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<400> 1975
Met Cys Glu Val Leu Asp Ile His Asn Ile Asp Glu Gln Pro Arg Pro 
1               5                   10                  15      


Leu Xaa Asp Ser His Arg Val Lys Phe Xaa Lys Glu Ile Lys Gly Leu 
            20                  25                  30          


Lys Val Glu Val Xaa His Cys Gly Xaa Met Arg Arg Lys Tyr Arg Val 
        35                  40                  45              


Cys Asn Val Xaa Arg Arg Pro Ala Ser His Gln Xaa Phe Pro Leu Gln 
    50                  55                  60                  


Leu Glu Asn Gly Gln Xaa Val Glu Arg Xaa Val Ala Gln Tyr Phe Arg 
65                  70                  75                  80  


Glu Lys Tyr Xaa Leu Gln Leu Lys Tyr Pro His Leu Pro Cys Leu Gln 
                85                  90                  95      


Val Gly Gln Glu Gln Lys His Xaa Tyr Leu Pro Leu Glu Val Cys Asn 
            100                 105                 110         


Ile Val Ala Gly Gln Arg Cys Ile Lys Lys Leu Xaa Asp Asn Gln Xaa 
        115                 120                 125             


Ser Xaa Met Ile Lys Ala Xaa Ala Arg Ser Ala Pro Asp Arg Gln Glu 
    130                 135                 140                 


Glu Ile Ser Arg Leu Val Arg Ser Ala Asn Tyr Glu Xaa Asp Pro Phe 
145                 150                 155                 160 


Val Gln Glu Phe Gln Phe Lys Val Arg Asp Glu Met Ala His Val Xaa 
                165                 170                 175     


Gly Arg Val Leu Pro Ala Pro Met Leu Gln Tyr Gly Gly Arg Asn Arg 
            180                 185                 190         


Xaa Val Ala Xaa Pro Ser His Gly Val Trp Asp Met Arg Gly Lys Gln 
        195                 200                 205             


Phe His Xaa Gly Val Glu Ile Lys Met Trp Ala Ile Ala Cys Phe Ala 
    210                 215                 220                 


Xaa Gln Arg Gln Cys Arg Glu Glu Ile Leu Lys Gly Phe Xaa Asp Gln 
225                 230                 235                 240 


Leu Arg Lys Ile Ser Lys Asp Ala Gly Met Pro Ile Gln Gly Gln Pro 
                245                 250                 255     


Cys Phe Cys Lys Tyr Ala Gln Gly Ala Asp Ser Val Glu Pro Met Phe 
            260                 265                 270         


Arg His Leu Lys Asn Xaa Tyr Ser Gly Leu Gln Leu Ile Ile Val Ile 
        275                 280                 285             


Leu Pro Gly Lys Xaa Pro Val Tyr Ala Glu Val Lys Arg Val Gly Asp 
    290                 295                 300                 


Xaa Leu Leu Gly Met Ala Xaa Gln Cys Val Gln Val Lys Asn Val Ile 
305                 310                 315                 320 


Lys Xaa Ser Pro Gln Xaa Leu Ser Asn Leu Cys Leu Lys Ile Asn Val 
                325                 330                 335     


Lys Leu Gly Gly Ile Asn Asn Ile Leu Val Pro His Gln Arg Pro Ser 
            340                 345                 350         


Val Phe Gln Gln Pro Val Ile Phe Leu Gly Ala Asp Val Xaa His Pro 
        355                 360                 365             


Pro Ala Gly Asp Gly Lys Lys Pro Ser Ile Ala Ala Val Val Gly Ser 
    370                 375                 380                 


Met Asp Ala His Pro Ser Arg Tyr Cys Ala Xaa Val Arg Val Gln Arg 
385                 390                 395                 400 


Pro Arg Gln Glu Ile Ile Gln Asp Leu Ala Ser Met Val Arg Glu Leu 
                405                 410                 415     


Leu Ile Gln Phe Tyr Lys Ser Xaa Arg Phe Lys Pro Xaa Arg Ile Ile 
            420                 425                 430         


Phe Tyr Arg Asp Gly Val Ser Glu Gly Gln Phe Arg Gln Val Leu Tyr 
        435                 440                 445             


Tyr Glu Leu Leu Ala Ile Arg Glu Ala Cys Ile Ser Leu Glu Lys Asp 
    450                 455                 460                 


Tyr Gln Pro Gly Ile Xaa Tyr Ile Val Val Gln Lys Arg His His Xaa 
465                 470                 475                 480 


Arg Leu Phe Cys Ala Asp Arg Xaa Glu Arg Val Gly Arg Ser Gly Asn 
                485                 490                 495     


Ile Pro Ala Gly Xaa Xaa Val Asp Xaa Asp Ile Xaa His Pro Tyr Glu 
            500                 505                 510         


Phe Asp Phe Tyr Leu Cys Ser His Ala Gly Ile Gln Gly Xaa Ser Arg 
        515                 520                 525             


Pro Ser His Tyr His Val Leu Trp Asp Asp Asn Cys Phe Xaa Ala Asp 
    530                 535                 540                 


Glu Leu Gln Leu Leu Xaa Tyr Gln Leu Cys His Xaa Tyr Val Arg Cys 
545                 550                 555                 560 


Xaa Arg Ser Val Ser Ile Pro Ala Pro Ala Tyr Tyr Ala His Leu Val 
                565                 570                 575     


Ala Phe Arg Ala Arg Tyr His Leu Val Asp Lys Glu His Asp Ser Ala 
            580                 585                 590         


Glu Gly Ser His Val Ser Gly Gln Ser Asn Gly Arg Asp Pro Gln Ala 
        595                 600                 605             


Leu Ala Lys Ala Val Gln Ile His Gln Asp Xaa Leu Arg Xaa Met Tyr 
    610                 615                 620                 


Phe Ala 
625     


<210> 1976
<211> 64
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<400> 1976
Met Glu Ile Gly Ser Ala Gly Pro Ala Gly Ala Gln Pro Leu Leu Met 
1               5                   10                  15      


Val Pro Arg Arg Pro Gly Tyr Gly Xaa Met Gly Lys Pro Ile Lys Leu 
            20                  25                  30          


Leu Ala Asn Cys Phe Gln Val Glu Ile Pro Lys Ile Asp Val Tyr Leu 
        35                  40                  45              


Tyr Glu Val Asp Ile Lys Pro Asp Lys Cys Pro Arg Arg Val Asn Arg 
    50                  55                  60                  


<210> 1977
<211> 229
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<400> 1977
Met Glu Ile Gly Ser Ala Gly Pro Ala Gly Ala Gln Pro Leu Leu Met 
1               5                   10                  15      


Val Pro Arg Arg Pro Gly Tyr Gly Xaa Met Gly Lys Pro Ile Lys Leu 
            20                  25                  30          


Leu Ala Asn Cys Phe Gln Val Glu Ile Pro Lys Ile Asp Val Tyr Leu 
        35                  40                  45              


Tyr Glu Val Asp Ile Lys Pro Asp Lys Cys Pro Arg Arg Val Asn Arg 
    50                  55                  60                  


Glu Val Val Asp Ser Met Val Gln His Phe Lys Val Xaa Ile Phe Gly 
65                  70                  75                  80  


Asp Arg Arg Pro Val Tyr Asp Gly Lys Arg Ser Leu Tyr Xaa Ala Asn 
                85                  90                  95      


Pro Leu Pro Val Ala Xaa Xaa Gly Val Asp Leu Asp Val Xaa Leu Pro 
            100                 105                 110         


Gly Glu Gly Gly Lys Asp Arg Pro Phe Lys Val Ser Ile Lys Phe Val 
        115                 120                 125             


Ser Arg Val Ser Trp His Leu Leu His Glu Val Leu Xaa Gly Arg Xaa 
    130                 135                 140                 


Leu Pro Glu Pro Leu Glu Leu Asp Lys Pro Ile Ser Xaa Asn Pro Val 
145                 150                 155                 160 


His Ala Val Asp Val Val Leu Arg His Leu Pro Ser Met Lys Tyr Xaa 
                165                 170                 175     


Pro Val Gly Arg Ser Phe Phe Ser Ala Pro Glu Gly Tyr Asp His Pro 
            180                 185                 190         


Leu Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser Val Arg 
        195                 200                 205             


Pro Ala Met Trp Lys Met Met Leu Asn Ile Asp Glu Arg Asp Leu Trp 
    210                 215                 220                 


Gln Gln Cys Gly Glu 
225                 


<210> 1978
<211> 860
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<400> 1978
Met Glu Ile Gly Ser Ala Gly Pro Ala Gly Ala Gln Pro Leu Leu Met 
1               5                   10                  15      


Val Pro Arg Arg Pro Gly Tyr Gly Xaa Met Gly Lys Pro Ile Lys Leu 
            20                  25                  30          


Leu Ala Asn Cys Phe Gln Val Glu Ile Pro Lys Ile Asp Val Tyr Leu 
        35                  40                  45              


Tyr Glu Val Asp Ile Lys Pro Asp Lys Cys Pro Arg Arg Val Asn Arg 
    50                  55                  60                  


Glu Val Val Asp Ser Met Val Gln His Phe Lys Val Xaa Ile Phe Gly 
65                  70                  75                  80  


Asp Arg Arg Pro Val Tyr Asp Gly Lys Arg Ser Leu Tyr Xaa Ala Asn 
                85                  90                  95      


Pro Leu Pro Val Ala Xaa Xaa Gly Val Asp Leu Asp Val Xaa Leu Pro 
            100                 105                 110         


Gly Glu Gly Gly Lys Asp Arg Pro Phe Lys Val Ser Ile Lys Phe Val 
        115                 120                 125             


Ser Arg Val Ser Trp His Leu Leu His Glu Val Leu Xaa Gly Arg Xaa 
    130                 135                 140                 


Leu Pro Glu Pro Leu Glu Leu Asp Lys Pro Ile Ser Xaa Asn Pro Val 
145                 150                 155                 160 


His Ala Val Asp Val Val Leu Arg His Leu Pro Ser Met Lys Tyr Xaa 
                165                 170                 175     


Pro Val Gly Arg Ser Phe Phe Ser Ala Pro Glu Gly Tyr Asp His Pro 
            180                 185                 190         


Leu Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser Val Arg 
        195                 200                 205             


Pro Ala Met Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala Xaa Ala 
    210                 215                 220                 


Phe Tyr Lys Ala Gln Pro Val Ile Gln Phe Met Cys Glu Val Leu Asp 
225                 230                 235                 240 


Ile His Asn Ile Asp Glu Gln Pro Arg Pro Leu Xaa Asp Ser His Arg 
                245                 250                 255     


Val Lys Phe Xaa Lys Glu Ile Lys Gly Leu Lys Val Glu Val Xaa His 
            260                 265                 270         


Cys Gly Xaa Met Arg Arg Lys Tyr Arg Val Cys Asn Val Xaa Arg Arg 
        275                 280                 285             


Pro Ala Ser His Gln Xaa Phe Pro Leu Gln Leu Glu Asn Gly Gln Xaa 
    290                 295                 300                 


Val Glu Arg Xaa Val Ala Gln Tyr Phe Arg Glu Lys Tyr Xaa Leu Gln 
305                 310                 315                 320 


Leu Lys Tyr Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu Gln Lys 
                325                 330                 335     


His Xaa Tyr Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly Gln Arg 
            340                 345                 350         


Cys Ile Lys Lys Leu Xaa Asp Asn Gln Xaa Ser Xaa Met Ile Lys Ala 
        355                 360                 365             


Xaa Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Arg Leu Val 
    370                 375                 380                 


Arg Ser Ala Asn Tyr Glu Xaa Asp Pro Phe Val Gln Glu Phe Gln Phe 
385                 390                 395                 400 


Lys Val Arg Asp Glu Met Ala His Val Xaa Gly Arg Val Leu Pro Ala 
                405                 410                 415     


Pro Met Leu Gln Tyr Gly Gly Arg Asn Arg Xaa Val Ala Xaa Pro Ser 
            420                 425                 430         


His Gly Val Trp Asp Met Arg Gly Lys Gln Phe His Xaa Gly Val Glu 
        435                 440                 445             


Ile Lys Met Trp Ala Ile Ala Cys Phe Ala Xaa Gln Arg Gln Cys Arg 
    450                 455                 460                 


Glu Glu Ile Leu Lys Gly Phe Xaa Asp Gln Leu Arg Lys Ile Ser Lys 
465                 470                 475                 480 


Asp Ala Gly Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys Tyr Ala 
                485                 490                 495     


Gln Gly Ala Asp Ser Val Glu Pro Met Phe Arg His Leu Lys Asn Xaa 
            500                 505                 510         


Tyr Ser Gly Leu Gln Leu Ile Ile Val Ile Leu Pro Gly Lys Xaa Pro 
        515                 520                 525             


Val Tyr Ala Glu Val Lys Arg Val Gly Asp Xaa Leu Leu Gly Met Ala 
    530                 535                 540                 


Xaa Gln Cys Val Gln Val Lys Asn Val Ile Lys Xaa Ser Pro Gln Xaa 
545                 550                 555                 560 


Leu Ser Asn Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly Ile Asn 
                565                 570                 575     


Asn Ile Leu Val Pro His Gln Arg Pro Ser Val Phe Gln Gln Pro Val 
            580                 585                 590         


Ile Phe Leu Gly Ala Asp Val Xaa His Pro Pro Ala Gly Asp Gly Lys 
        595                 600                 605             


Lys Pro Ser Ile Ala Ala Val Val Gly Ser Met Asp Ala His Pro Ser 
    610                 615                 620                 


Arg Tyr Cys Ala Xaa Val Arg Val Gln Arg Pro Arg Gln Glu Ile Ile 
625                 630                 635                 640 


Gln Asp Leu Ala Ser Met Val Arg Glu Leu Leu Ile Gln Phe Tyr Lys 
                645                 650                 655     


Ser Xaa Arg Phe Lys Pro Xaa Arg Ile Ile Phe Tyr Arg Asp Gly Val 
            660                 665                 670         


Ser Glu Gly Gln Phe Arg Gln Val Leu Tyr Tyr Glu Leu Leu Ala Ile 
        675                 680                 685             


Arg Glu Ala Cys Ile Ser Leu Glu Lys Asp Tyr Gln Pro Gly Ile Xaa 
    690                 695                 700                 


Tyr Ile Val Val Gln Lys Arg His His Xaa Arg Leu Phe Cys Ala Asp 
705                 710                 715                 720 


Arg Xaa Glu Arg Val Gly Arg Ser Gly Asn Ile Pro Ala Gly Xaa Xaa 
                725                 730                 735     


Val Asp Xaa Asp Ile Xaa His Pro Tyr Glu Phe Asp Phe Tyr Leu Cys 
            740                 745                 750         


Ser His Ala Gly Ile Gln Gly Xaa Ser Arg Pro Ser His Tyr His Val 
        755                 760                 765             


Leu Trp Asp Asp Asn Cys Phe Xaa Ala Asp Glu Leu Gln Leu Leu Xaa 
    770                 775                 780                 


Tyr Gln Leu Cys His Xaa Tyr Val Arg Cys Xaa Arg Ser Val Ser Ile 
785                 790                 795                 800 


Pro Ala Pro Ala Tyr Tyr Ala His Leu Val Ala Phe Arg Ala Arg Tyr 
                805                 810                 815     


His Leu Val Asp Lys Glu His Asp Ser Ala Glu Gly Ser His Val Ser 
            820                 825                 830         


Gly Gln Ser Asn Gly Arg Asp Pro Gln Ala Leu Ala Lys Ala Val Gln 
        835                 840                 845             


Ile His Gln Asp Xaa Leu Arg Xaa Met Tyr Phe Ala 
    850                 855                 860 


<210> 1979
<211> 861
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<400> 1979
Met Glu Ala Leu Gly Pro Gly Pro Pro Ala Ser Leu Phe Gln Pro Pro 
1               5                   10                  15      


Arg Arg Pro Gly Leu Gly Xaa Val Gly Lys Pro Ile Arg Leu Leu Ala 
            20                  25                  30          


Asn His Phe Gln Val Gln Ile Pro Lys Ile Asp Val Tyr His Tyr Asp 
        35                  40                  45              


Val Asp Ile Lys Pro Glu Lys Arg Pro Arg Arg Val Asn Arg Glu Val 
    50                  55                  60                  


Val Asp Xaa Met Val Arg His Phe Lys Met Gln Ile Phe Gly Asp Arg 
65                  70                  75                  80  


Gln Pro Gly Tyr Asp Gly Lys Arg Asn Met Tyr Xaa Ala His Pro Leu 
                85                  90                  95      


Pro Ile Gly Arg Asp Arg Val Asp Met Glu Val Xaa Leu Pro Gly Glu 
            100                 105                 110         


Gly Lys Asp Gln Xaa Phe Lys Val Ser Val Gln Trp Val Ser Val Val 
        115                 120                 125             


Ser Leu Gln Leu Leu Leu Glu Ala Leu Ala Gly His Leu Asn Glu Val 
    130                 135                 140                 


Pro Asp Asp Ser Val Gln Ala Leu Asp Val Ile Xaa Arg His Leu Pro 
145                 150                 155                 160 


Ser Met Arg Tyr Xaa Pro Val Gly Arg Ser Phe Phe Ser Pro Pro Glu 
                165                 170                 175     


Gly Tyr Tyr His Pro Leu Gly Gly Gly Arg Glu Val Trp Phe Gly Phe 
            180                 185                 190         


His Gln Ser Val Arg Pro Ala Met Trp Asn Met Met Leu Asn Ile Asp 
        195                 200                 205             


Val Ser Ala Xaa Ala Phe Tyr Arg Ala Gln Pro Ile Ile Glu Phe Met 
    210                 215                 220                 


Cys Glu Val Leu Asp Ile Gln Asn Ile Asn Glu Gln Xaa Lys Pro Leu 
225                 230                 235                 240 


Xaa Asp Ser Gln Arg Val Lys Phe Xaa Lys Glu Ile Arg Gly Leu Lys 
                245                 250                 255     


Val Glu Val Xaa His Cys Gly Gln Met Lys Arg Lys Tyr Arg Val Cys 
            260                 265                 270         


Asn Val Xaa Arg Arg Pro Ala Ser His Gln Xaa Phe Pro Leu Gln Leu 
        275                 280                 285             


Glu Asn Gly Gln Ala Met Glu Cys Xaa Val Ala Gln Tyr Phe Lys Gln 
    290                 295                 300                 


Lys Tyr Ser Leu Gln Leu Lys Tyr Pro His Leu Pro Cys Leu Gln Val 
305                 310                 315                 320 


Gly Gln Glu Gln Lys His Xaa Tyr Leu Pro Leu Glu Val Cys Asn Ile 
                325                 330                 335     


Val Ala Gly Gln Arg Cys Ile Lys Lys Leu Xaa Asp Asn Gln Xaa Ser 
            340                 345                 350         


Xaa Met Ile Lys Ala Xaa Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu 
        355                 360                 365             


Ile Ser Arg Leu Val Lys Ser Asn Ser Met Val Gly Gly Pro Asp Pro 
    370                 375                 380                 


Tyr Leu Lys Glu Phe Gly Ile Val Val His Asn Glu Met Xaa Glu Leu 
385                 390                 395                 400 


Xaa Gly Arg Val Leu Pro Ala Pro Met Leu Gln Tyr Gly Gly Arg Asn 
                405                 410                 415     


Lys Xaa Val Ala Xaa Pro Asn Gln Gly Val Trp Asp Met Arg Gly Lys 
            420                 425                 430         


Gln Phe Tyr Ala Gly Ile Glu Ile Lys Val Trp Ala Val Ala Cys Phe 
        435                 440                 445             


Ala Pro Gln Lys Gln Cys Arg Glu Asp Leu Leu Lys Ser Phe Xaa Asp 
    450                 455                 460                 


Gln Leu Arg Lys Ile Ser Lys Asp Ala Gly Met Pro Ile Gln Gly Gln 
465                 470                 475                 480 


Pro Cys Phe Cys Lys Tyr Ala Gln Gly Ala Asp Ser Val Glu Pro Met 
                485                 490                 495     


Phe Lys His Leu Lys Met Xaa Tyr Val Gly Leu Gln Leu Ile Val Val 
            500                 505                 510         


Ile Leu Pro Gly Lys Xaa Pro Val Tyr Ala Glu Val Lys Arg Val Gly 
        515                 520                 525             


Asp Xaa Leu Leu Gly Met Ala Xaa Gln Cys Val Gln Val Lys Asn Val 
    530                 535                 540                 


Val Lys Xaa Ser Pro Gln Xaa Leu Ser Asn Leu Cys Leu Lys Ile Asn 
545                 550                 555                 560 


Ala Lys Leu Gly Gly Ile Asn Asn Val Leu Val Pro His Gln Arg Pro 
                565                 570                 575     


Ser Val Phe Gln Gln Pro Val Ile Phe Leu Gly Ala Asp Val Xaa His 
            580                 585                 590         


Pro Pro Ala Gly Asp Gly Lys Lys Pro Ser Ile Ala Ala Val Val Gly 
        595                 600                 605             


Ser Met Asp Gly His Pro Ser Arg Tyr Cys Ala Xaa Val Arg Val Gln 
    610                 615                 620                 


Xaa Ser Arg Gln Glu Ile Ser Gln Glu Leu Leu Tyr Ser Gln Glu Val 
625                 630                 635                 640 


Ile Gln Asp Leu Xaa Asn Met Val Arg Glu Leu Leu Ile Gln Phe Tyr 
                645                 650                 655     


Lys Ser Xaa Arg Phe Lys Pro Xaa Arg Ile Ile Tyr Tyr Arg Gly Gly 
            660                 665                 670         


Val Ser Glu Gly Gln Met Lys Gln Val Ala Trp Pro Glu Leu Ile Ala 
        675                 680                 685             


Ile Arg Lys Ala Cys Ile Ser Leu Glu Glu Asp Tyr Arg Pro Gly Ile 
    690                 695                 700                 


Xaa Tyr Ile Val Val Gln Lys Arg His His Xaa Arg Leu Phe Cys Ala 
705                 710                 715                 720 


Asp Lys Xaa Glu Arg Val Gly Lys Ser Gly Asn Val Pro Ala Gly Xaa 
                725                 730                 735     


Xaa Val Asp Ser Xaa Ile Xaa His Pro Ser Glu Phe Asp Phe Tyr Leu 
            740                 745                 750         


Cys Ser His Ala Gly Ile Gln Gly Xaa Ser Arg Pro Ser His Tyr Gln 
        755                 760                 765             


Val Leu Trp Asp Asp Asn Cys Phe Xaa Ala Asp Glu Leu Gln Leu Leu 
    770                 775                 780                 


Xaa Tyr Gln Leu Cys His Xaa Tyr Val Arg Cys Xaa Arg Ser Val Ser 
785                 790                 795                 800 


Ile Pro Ala Pro Ala Tyr Tyr Ala Arg Leu Val Ala Phe Arg Ala Arg 
                805                 810                 815     


Tyr His Leu Val Asp Lys Asp His Asp Ser Ala Glu Gly Ser His Val 
            820                 825                 830         


Ser Gly Gln Ser Asn Gly Arg Asp Pro Gln Ala Leu Ala Lys Ala Val 
        835                 840                 845             


Gln Ile His His Asp Xaa Gln His Xaa Met Tyr Phe Ala 
    850                 855                 860     


<210> 1980
<211> 283
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<400> 1980
Met Asp Leu Trp Pro Gly Ala Trp Met Leu Leu Leu Leu Leu Phe Leu 
1               5                   10                  15      


Leu Leu Leu Phe Leu Leu Pro Xaa Leu Trp Phe Cys Ser Pro Ser Ala 
            20                  25                  30          


Lys Tyr Phe Phe Lys Met Ala Phe Tyr Asn Gly Trp Ile Leu Phe Leu 
        35                  40                  45              


Ala Val Leu Ala Ile Pro Val Cys Ala Val Arg Gly Arg Asn Val Glu 
    50                  55                  60                  


Asn Met Lys Ile Leu Arg Leu Met Leu Leu His Ile Lys Tyr Leu Tyr 
65                  70                  75                  80  


Gly Ile Arg Val Glu Val Arg Gly Ala His His Phe Pro Pro Ser Gln 
                85                  90                  95      


Pro Tyr Val Val Val Ser Asn His Gln Ser Ser Leu Asp Leu Leu Gly 
            100                 105                 110         


Met Met Glu Val Leu Pro Gly Arg Cys Val Pro Ile Ala Lys Arg Glu 
        115                 120                 125             


Leu Leu Trp Ala Gly Ser Ala Gly Leu Ala Cys Trp Leu Ala Gly Val 
    130                 135                 140                 


Ile Phe Ile Asp Arg Lys Arg Xaa Gly Asp Ala Ile Ser Val Met Ser 
145                 150                 155                 160 


Glu Val Ala Gln Xaa Leu Leu Xaa Gln Asp Val Arg Val Trp Val Phe 
                165                 170                 175     


Pro Glu Gly Xaa Arg Asn His Asn Gly Ser Met Leu Pro Phe Lys Arg 
            180                 185                 190         


Gly Ala Phe His Leu Ala Val Gln Ala Gln Val Pro Ile Val Pro Ile 
        195                 200                 205             


Val Met Ser Ser Tyr Gln Asp Phe Tyr Cys Lys Lys Glu Arg Arg Phe 
    210                 215                 220                 


Xaa Ser Gly Gln Cys Gln Val Arg Val Leu Pro Pro Val Pro Xaa Glu 
225                 230                 235                 240 


Gly Leu Xaa Pro Asp Asp Val Pro Ala Leu Ala Asp Arg Val Arg His 
                245                 250                 255     


Ser Met Leu Xaa Val Phe Arg Glu Ile Ser Xaa Asp Gly Arg Gly Gly 
            260                 265                 270         


Gly Asp Tyr Leu Lys Lys Pro Gly Gly Gly Gly 
        275                 280             


<210> 1981
<211> 278
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<400> 1981
Met Glu Leu Trp Pro Cys Leu Ala Ala Ala Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Gln Leu Ser Arg Ala Ala Glu Phe Tyr Ala Lys Val Ala Leu 
            20                  25                  30          


Tyr Cys Ala Leu Cys Phe Xaa Val Ser Ala Val Ala Ser Leu Val Cys 
        35                  40                  45              


Leu Leu Arg His Gly Gly Arg Xaa Val Glu Asn Met Ser Ile Ile Gly 
    50                  55                  60                  


Trp Phe Val Arg Ser Phe Lys Tyr Phe Tyr Gly Leu Arg Phe Glu Val 
65                  70                  75                  80  


Arg Asp Pro Arg Arg Leu Gln Glu Ala Arg Pro Cys Val Ile Val Ser 
                85                  90                  95      


Asn His Gln Ser Ile Leu Asp Met Met Gly Leu Met Glu Val Leu Pro 
            100                 105                 110         


Glu Arg Cys Val Gln Ile Ala Lys Arg Glu Leu Leu Phe Leu Gly Pro 
        115                 120                 125             


Val Gly Leu Ile Met Tyr Leu Gly Gly Val Phe Phe Ile Asn Arg Gln 
    130                 135                 140                 


Arg Ser Ser Xaa Ala Met Xaa Val Met Ala Asp Leu Gly Glu Arg Met 
145                 150                 155                 160 


Val Arg Glu Asn Leu Lys Val Trp Ile Tyr Pro Glu Gly Xaa Arg Asn 
                165                 170                 175     


Asp Asn Gly Asp Leu Leu Pro Phe Lys Lys Gly Ala Phe Tyr Leu Ala 
            180                 185                 190         


Val Gln Ala Gln Val Pro Ile Val Pro Val Val Tyr Ser Ser Phe Ser 
        195                 200                 205             


Ser Phe Tyr Asn Xaa Lys Lys Lys Phe Phe Xaa Ser Gly Xaa Val Xaa 
    210                 215                 220                 


Val Gln Val Leu Glu Ala Ile Pro Xaa Ser Gly Leu Xaa Ala Ala Asp 
225                 230                 235                 240 


Val Pro Ala Leu Val Asp Xaa Cys His Arg Ala Met Arg Xaa Xaa Phe 
                245                 250                 255     


Leu His Ile Ser Lys Xaa Pro Gln Glu Asn Gly Ala Xaa Ala Gly Ser 
            260                 265                 270         


Gly Val Gln Pro Ala Gln 
        275             


<210> 1982
<211> 246
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<400> 1982
Met Glu Leu Trp Pro Cys Leu Ala Ala Ala Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Gln Leu Ser Arg Ala Ala Glu Phe Tyr Ala Lys Val Ala Leu 
            20                  25                  30          


Tyr Cys Ala Leu Cys Phe Xaa Val Ser Ala Val Ala Ser Leu Val Cys 
        35                  40                  45              


Leu Leu Arg His Gly Gly Arg Xaa Val Glu Asn Met Ser Ile Ile Gly 
    50                  55                  60                  


Trp Phe Val Arg Ser Phe Lys Tyr Phe Tyr Gly Leu Arg Phe Glu Val 
65                  70                  75                  80  


Arg Asp Pro Arg Arg Leu Gln Glu Ala Arg Pro Cys Val Ile Val Ser 
                85                  90                  95      


Asn His Gln Ser Ile Leu Asp Met Met Gly Leu Met Glu Val Leu Pro 
            100                 105                 110         


Glu Arg Cys Val Gln Ile Ala Lys Arg Glu Leu Leu Phe Leu Gly Pro 
        115                 120                 125             


Val Gly Leu Ile Met Tyr Leu Gly Gly Val Phe Phe Ile Asn Arg Gln 
    130                 135                 140                 


Arg Ser Ser Xaa Ala Met Xaa Val Met Ala Asp Leu Gly Glu Arg Met 
145                 150                 155                 160 


Val Arg Glu Asn Val Pro Ile Val Pro Val Val Tyr Ser Ser Phe Ser 
                165                 170                 175     


Ser Phe Tyr Asn Xaa Lys Lys Lys Phe Phe Xaa Ser Gly Xaa Val Xaa 
            180                 185                 190         


Val Gln Val Leu Glu Ala Ile Pro Xaa Ser Gly Leu Xaa Ala Ala Asp 
        195                 200                 205             


Val Pro Ala Leu Val Asp Xaa Cys His Arg Ala Met Arg Xaa Xaa Phe 
    210                 215                 220                 


Leu His Ile Ser Lys Xaa Pro Gln Glu Asn Gly Ala Xaa Ala Gly Ser 
225                 230                 235                 240 


Gly Val Gln Pro Ala Gln 
                245     


<210> 1983
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<400> 1983
Met Glu Lys Ile Pro Val Ser Ala Phe Leu Leu Leu Val Ala Leu Ser 
1               5                   10                  15      


Tyr Xaa Leu Ala Arg Asp Xaa Xaa Val Lys Pro Gly Ala Lys Lys Asp 
            20                  25                  30          


Xaa Lys Asp Ser Arg Pro Lys Leu Pro Gln Xaa Leu Ser Arg Gly Trp 
        35                  40                  45              


Gly Asp Gln Leu Ile Trp Xaa Gln Xaa Tyr Glu Glu Ala Leu Tyr Lys 
    50                  55                  60                  


Ser Lys Xaa Ser Asn Lys Pro Leu Met Ile Ile His His Leu Asp Glu 
65                  70                  75                  80  


Cys Pro His Ser Gln Ala Leu Lys Lys Val Phe Ala Glu Asn Lys Glu 
                85                  90                  95      


Ile Gln Lys Leu Ala Glu Gln Phe Val Leu Leu Asn Leu Val Tyr Glu 
            100                 105                 110         


Xaa Xaa Asp Lys His Leu Ser Pro Asp Gly Gln Tyr Val Pro Arg Ile 
        115                 120                 125             


Met Phe Val 
    130     


<210> 1984
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<400> 1984
Met Glu Lys Ile Pro Val Ser Ala Phe Leu Leu Leu Val Ala Leu Ser 
1               5                   10                  15      


Tyr Xaa Leu Ala Arg Asp Xaa Xaa Val Lys Pro Gly Ala Lys Lys Asp 
            20                  25                  30          


Xaa Lys Asp Ser Arg Pro Lys Leu Pro Gln Xaa Leu Ser Arg Gly Trp 
        35                  40                  45              


Gly Asp Gln Leu Ile Trp Xaa Gln Xaa Tyr Glu Glu Ala Leu Tyr Lys 
    50                  55                  60                  


Ser Lys Xaa Ser Asn Lys Pro Leu Met Ile Ile His His Leu Asp Glu 
65                  70                  75                  80  


Cys Pro His Ser Gln Ala Leu Lys Lys Val Phe Ala Glu Asn Lys Glu 
                85                  90                  95      


Ile Gln Lys Leu Ala Glu Gln Phe Val Leu Leu Asn Leu Val Tyr Glu 
            100                 105                 110         


Xaa Xaa Asp Lys His Leu Ser Pro Asp Gly Gln Tyr Val Pro Arg Ile 
        115                 120                 125             


Met Phe Val Asp Pro Ser Leu Xaa Val Arg Ala Asp Ile Xaa Gly Arg 
    130                 135                 140                 


Tyr Ser Asn Arg Leu Tyr Ala Tyr Glu Pro Ala Asp Xaa Ala Leu Cys 
145                 150                 155                 160 


Lys Cys Asp Leu Gln Phe Gly Cys Cys Pro Arg Val Glu His Leu Tyr 
                165                 170                 175     


Cys Cys Ser Asp Gly Xaa Arg Gly Cys Met Val Arg 
            180                 185             


<210> 1985
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 1985
Met Glu Lys Ile Pro Val Ser Ala Phe Leu Leu Leu Val Ala Leu Ser 
1               5                   10                  15      


Tyr Xaa Leu Ala Arg Asp Xaa Xaa Val Lys Pro Gly Ala Lys Lys Asp 
            20                  25                  30          


Xaa Lys Asp Ser Arg Pro Lys Leu Pro Gln Xaa Leu Ser Arg Gly Trp 
        35                  40                  45              


Gly Asp Gln Leu Ile Trp Xaa Gln Xaa Tyr Glu Glu Ala Leu Tyr Lys 
    50                  55                  60                  


Ser Lys Xaa Ser Asn Lys Pro Leu Met Ile Ile His His Leu Asp Glu 
65                  70                  75                  80  


Cys Pro His Ser Gln Ala Leu Lys Lys Val Phe Ala Glu Asn Lys Glu 
                85                  90                  95      


Ile Gln Lys Leu Ala Glu Gln Phe Val Leu Leu Asn Leu Val Tyr Glu 
            100                 105                 110         


Xaa Xaa Asp Lys His Leu Ser Pro Asp Gly Gln Tyr Val Pro Arg Ile 
        115                 120                 125             


Met Phe Val Asp Pro Ser Leu Xaa Val Arg Ala Asp Ile Xaa Gly Arg 
    130                 135                 140                 


Tyr Ser Asn Arg Leu Tyr Ala Tyr Glu Pro Ala Asp Xaa Ala Leu Leu 
145                 150                 155                 160 


Leu Asp Asn Met Lys Lys Ala Leu Lys Leu Leu Lys Xaa Glu Leu 
                165                 170                 175 


<210> 1986
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<400> 1986
Pro Leu Met Ile Ile His His Leu Asp Glu Cys Pro His Ser Gln Ala 
1               5                   10                  15      


Leu Lys Lys Val Phe Ala Glu Asn Lys Glu Ile Gln Lys Leu Ala Glu 
            20                  25                  30          


Gln Phe Val Leu Leu Asn Leu Val Tyr Glu Xaa Xaa Asp Lys His Leu 
        35                  40                  45              


Ser Pro Asp Gly Gln Tyr Val Pro Arg Ile Met Phe Val Asp Pro Ser 
    50                  55                  60                  


Leu Xaa Val Arg Ala Asp Ile Xaa Gly Arg Tyr Ser Asn Arg Leu Tyr 
65                  70                  75                  80  


Ala Tyr Glu Pro Ala Asp Xaa Ala Leu Cys Lys Cys Asp Leu Gln Phe 
                85                  90                  95      


Gly Cys Cys Pro Arg Val Glu His Leu Tyr Cys Cys Ser Asp Gly Xaa 
            100                 105                 110         


Arg Gly Cys Met Val Ser Ala 
        115                 


<210> 1987
<211> 2045
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1131)..(1131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1211)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1270)..(1270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1294)..(1294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1306)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1343)..(1343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1354)..(1354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1387)..(1387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1393)..(1393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1436)..(1436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1444)..(1444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1467)..(1467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1474)..(1474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1484)..(1484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1491)..(1491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1510)..(1510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1540)..(1540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1584)..(1584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1622)..(1622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1626)..(1626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1653)..(1653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1684)..(1684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1720)..(1720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1725)..(1725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1755)..(1755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1800)..(1800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1811)..(1811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1819)..(1819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1866)..(1866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1873)..(1873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1882)..(1882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1899)..(1899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1902)..(1902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1913)..(1913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1944)..(1944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1949)..(1949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1975)..(1975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1983)..(1983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1987)..(1987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2011)..(2011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2035)..(2035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2044)..(2044)
<223> Selenocysteine

<400> 1987
Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly Xaa Cys Pro 
            20                  25                  30          


Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val Leu Xaa 
        35                  40                  45              


Gly Xaa Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His Xaa Tyr 
    50                  55                  60                  


Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp Leu Val 
65                  70                  75                  80  


Ala Arg Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile Ser Gly 
                85                  90                  95      


Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Xaa Gly Asp Xaa 
            100                 105                 110         


Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro Ala His 
        115                 120                 125             


Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Xaa Leu Arg 
    130                 135                 140                 


Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly Xaa His 
145                 150                 155                 160 


Phe Xaa Pro Val Pro Pro Xaa Pro Pro Asp Ala Cys Arg Gly Met Leu 
                165                 170                 175     


Cys Gly Phe Gly Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg 
            180                 185                 190         


Ala Ser Cys Val Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro 
        195                 200                 205             


Val Cys Gly Ser Asp Ala Ser Xaa Tyr Ser Asn Glu Cys Glu Leu Gln 
    210                 215                 220                 


Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly 
225                 230                 235                 240 


Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn Val Xaa Cys Ser Phe Gly 
                245                 250                 255     


Ser Xaa Cys Ala Arg Ser Ala Asp Gly Leu Xaa Ala Ser Cys Leu Cys 
            260                 265                 270         


Pro Ala Xaa Cys Arg Gly Ala Pro Glu Gly Xaa Val Cys Gly Ser Asp 
        275                 280                 285             


Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala 
    290                 295                 300                 


Arg Gln Glu Asn Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys 
305                 310                 315                 320 


Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg 
                325                 330                 335     


Xaa Arg Arg Pro Glu Met Leu Leu Arg Pro Glu Ser Cys Pro Ala Arg 
            340                 345                 350         


Gln Ala Pro Val Cys Gly Asp Asp Gly Val Xaa Tyr Glu Asn Asp Cys 
        355                 360                 365             


Val Met Gly Arg Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val 
    370                 375                 380                 


Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg 
385                 390                 395                 400 


Phe Asn Ala Val Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys 
                405                 410                 415     


Asp Arg Val Xaa Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp 
            420                 425                 430         


Gly Arg Xaa Tyr Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg 
        435                 440                 445             


Gln Gln Arg Ala Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala 
    450                 455                 460                 


Pro Ser Pro Cys Leu Gly Val Gln Cys Ala Phe Gly Ala Xaa Cys Ala 
465                 470                 475                 480 


Val Lys Asn Gly Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser 
                485                 490                 495     


Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Xaa Tyr Gly Ser Ala 
            500                 505                 510         


Cys Glu Leu Glu Ala Xaa Ala Cys Xaa Leu Gly Arg Glu Ile Gln Val 
        515                 520                 525             


Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala 
    530                 535                 540                 


Leu Cys Glu Ala Glu Xaa Gly Arg Cys Val Cys Pro Ser Glu Cys Val 
545                 550                 555                 560 


Ala Leu Ala Gln Pro Val Cys Gly Ser Asp Gly His Xaa Tyr Pro Ser 
                565                 570                 575     


Glu Cys Met Leu His Val His Ala Cys Xaa His Gln Ile Ser Leu His 
            580                 585                 590         


Val Ala Ser Ala Gly Pro Cys Glu Xaa Cys Gly Asp Ala Val Cys Ala 
        595                 600                 605             


Phe Gly Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu 
    610                 615                 620                 


His Pro Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Xaa Tyr Gly 
625                 630                 635                 640 


Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys Leu Gln Gln Xaa Gln Ile 
                645                 650                 655     


Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly 
            660                 665                 670         


Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg 
        675                 680                 685             


Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val 
    690                 695                 700                 


Cys Asp Phe Ser Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser 
705                 710                 715                 720 


Asp Gly Val Xaa Tyr Ser Xaa Glu Cys Glu Leu Lys Lys Ala Arg Cys 
                725                 730                 735     


Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly 
            740                 745                 750         


Pro Xaa Phe Ala Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln 
        755                 760                 765             


Xaa Pro Tyr Gly Cys Cys Gln Asp Asn Ile Xaa Ala Ala Arg Gly Val 
    770                 775                 780                 


Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser 
785                 790                 795                 800 


Tyr Gly Gly Xaa Cys Asp Pro Ala Xaa Gly Gln Cys Ser Cys Arg Pro 
                805                 810                 815     


Gly Val Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn 
            820                 825                 830         


Phe Arg Gly Ile Val Xaa Asp Gly Arg Ser Gly Cys Xaa Pro Cys Ser 
        835                 840                 845             


Cys Asp Pro Gln Gly Ala Val Arg Asp Asp Cys Glu Gln Met Xaa Gly 
    850                 855                 860                 


Leu Cys Ser Cys Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys 
865                 870                 875                 880 


Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser 
                885                 890                 895     


Ala Pro Ala Xaa Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys 
            900                 905                 910         


Val Glu Glu Ser Gly Ser Ala His Cys Val Cys Pro Met Leu Xaa Cys 
        915                 920                 925             


Pro Glu Ala Asn Ala Xaa Lys Val Cys Gly Ser Asp Gly Val Xaa Tyr 
    930                 935                 940                 


Gly Asn Glu Cys Gln Leu Lys Xaa Ile Ala Cys Arg Gln Gly Leu Gln 
945                 950                 955                 960 


Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser 
                965                 970                 975     


Xaa His Pro Xaa Ser Ala Ser Val Xaa Val Xaa Xaa Pro Gly Leu Leu 
            980                 985                 990         


Leu Ser Gln Ala Leu Pro Ala Pro  Pro Gly Ala Leu Pro  Leu Ala Pro 
        995                 1000                 1005             


Ser Ser  Xaa Ala His Ser Gln  Xaa Xaa Pro Pro Pro  Ser Ser Arg 
    1010                 1015                 1020             


Pro Arg  Xaa Xaa Ala Ser Val  Pro Arg Xaa Xaa Val  Trp Pro Val 
    1025                 1030                 1035             


Leu Xaa  Val Pro Pro Xaa Ala  Pro Ser Pro Ala Pro  Ser Leu Val 
    1040                 1045                 1050             


Ala Ser  Ala Phe Gly Glu Ser  Gly Ser Xaa Asp Gly  Ser Ser Asp 
    1055                 1060                 1065             


Glu Glu  Leu Ser Gly Asp Gln  Glu Ala Ser Gly Gly  Gly Ser Gly 
    1070                 1075                 1080             


Gly Leu  Glu Pro Leu Glu Gly  Ser Ser Val Ala Xaa  Pro Gly Pro 
    1085                 1090                 1095             


Pro Val  Glu Arg Ala Ser Cys  Tyr Asn Ser Ala Leu  Gly Cys Cys 
    1100                 1105                 1110             


Ser Asp  Gly Lys Xaa Pro Ser  Leu Asp Ala Glu Gly  Ser Asn Cys 
    1115                 1120                 1125             


Pro Ala  Xaa Lys Val Phe Gln  Gly Val Leu Glu Leu  Glu Gly Val 
    1130                 1135                 1140             


Glu Gly  Gln Glu Leu Phe Tyr  Xaa Pro Glu Met Ala  Asp Pro Lys 
    1145                 1150                 1155             


Ser Glu  Leu Phe Gly Glu Xaa  Ala Arg Ser Ile Glu  Ser Xaa Leu 
    1160                 1165                 1170             


Asp Asp  Leu Phe Arg Asn Ser  Asp Val Lys Lys Asp  Phe Arg Ser 
    1175                 1180                 1185             


Val Arg  Leu Arg Asp Leu Gly  Pro Gly Lys Ser Val  Arg Ala Ile 
    1190                 1195                 1200             


Val Asp  Val His Phe Asp Pro  Xaa Xaa Ala Phe Arg  Ala Pro Asp 
    1205                 1210                 1215             


Val Ala  Arg Ala Leu Leu Arg  Gln Ile Gln Val Ser  Arg Arg Arg 
    1220                 1225                 1230             


Ser Leu  Gly Val Arg Arg Pro  Leu Gln Glu His Val  Arg Phe Met 
    1235                 1240                 1245             


Asp Phe  Asp Trp Phe Pro Ala  Phe Ile Xaa Gly Ala  Xaa Ser Gly 
    1250                 1255                 1260             


Ala Ile  Ala Ala Gly Ala Xaa  Ala Arg Ala Xaa Xaa  Ala Ser Arg 
    1265                 1270                 1275             


Leu Pro  Ser Ser Ala Val Xaa  Pro Arg Ala Pro His  Pro Ser His 
    1280                 1285                 1290             


Xaa Ser  Gln Pro Val Ala Lys  Xaa Xaa Ala Ala Pro  Xaa Xaa Arg 
    1295                 1300                 1305             


Arg Pro  Pro Xaa Xaa Ala Pro  Ser Arg Val Pro Gly  Arg Arg Pro 
    1310                 1315                 1320             


Pro Ala  Pro Gln Gln Pro Pro  Lys Pro Cys Asp Ser  Gln Pro Cys 
    1325                 1330                 1335             


Phe His  Gly Gly Xaa Cys Gln  Asp Trp Ala Leu Gly  Gly Gly Phe 
    1340                 1345                 1350             


Xaa Cys  Ser Cys Pro Ala Gly  Arg Gly Gly Ala Val  Cys Glu Lys 
    1355                 1360                 1365             


Val Leu  Gly Ala Pro Val Pro  Ala Phe Glu Gly Arg  Ser Phe Leu 
    1370                 1375                 1380             


Ala Phe  Pro Xaa Leu Arg Ala  Tyr His Xaa Leu Arg  Leu Ala Leu 
    1385                 1390                 1395             


Glu Phe  Arg Ala Leu Glu Pro  Gln Gly Leu Leu Leu  Tyr Asn Gly 
    1400                 1405                 1410             


Asn Ala  Arg Gly Lys Asp Phe  Leu Ala Leu Ala Leu  Leu Asp Gly 
    1415                 1420                 1425             


Arg Val  Gln Leu Arg Phe Asp  Xaa Gly Ser Gly Pro  Ala Val Leu 
    1430                 1435                 1440             


Xaa Ser  Ala Val Pro Val Glu  Pro Gly Gln Trp His  Arg Leu Glu 
    1445                 1450                 1455             


Leu Ser  Arg His Trp Arg Arg  Gly Xaa Leu Ser Val  Asp Gly Glu 
    1460                 1465                 1470             


Xaa Pro  Val Leu Gly Glu Ser  Pro Ser Gly Xaa Asp  Gly Leu Asn 
    1475                 1480                 1485             


Leu Asp  Xaa Asp Leu Phe Val  Gly Gly Val Pro Glu  Asp Gln Ala 
    1490                 1495                 1500             


Ala Val  Ala Leu Glu Arg Xaa  Phe Val Gly Ala Gly  Leu Arg Gly 
    1505                 1510                 1515             


Cys Ile  Arg Leu Leu Asp Val  Asn Asn Gln Arg Leu  Glu Leu Gly 
    1520                 1525                 1530             


Ile Gly  Pro Gly Ala Ala Xaa  Arg Gly Ser Gly Val  Gly Glu Cys 
    1535                 1540                 1545             


Gly Asp  His Pro Cys Leu Pro  Asn Pro Cys His Gly  Gly Ala Pro 
    1550                 1555                 1560             


Cys Gln  Asn Leu Glu Ala Gly  Arg Phe His Cys Gln  Cys Pro Pro 
    1565                 1570                 1575             


Gly Arg  Val Gly Pro Xaa Cys  Ala Asp Glu Lys Ser  Pro Cys Gln 
    1580                 1585                 1590             


Pro Asn  Pro Cys His Gly Ala  Ala Pro Cys Arg Val  Leu Pro Glu 
    1595                 1600                 1605             


Gly Gly  Ala Gln Cys Glu Cys  Pro Leu Gly Arg Glu  Gly Xaa Phe 
    1610                 1615                 1620             


Cys Gln  Xaa Ala Ser Gly Gln  Asp Gly Ser Gly Pro  Phe Leu Ala 
    1625                 1630                 1635             


Asp Phe  Asn Gly Phe Ser His  Leu Glu Leu Arg Gly  Leu His Xaa 
    1640                 1645                 1650             


Phe Ala  Arg Asp Leu Gly Glu  Lys Met Ala Leu Glu  Val Val Phe 
    1655                 1660                 1665             


Leu Ala  Arg Gly Pro Ser Gly  Leu Leu Leu Tyr Asn  Gly Gln Lys 
    1670                 1675                 1680             


Xaa Asp  Gly Lys Gly Asp Phe  Val Ser Leu Ala Leu  Arg Asp Arg 
    1685                 1690                 1695             


Arg Leu  Glu Phe Arg Tyr Asp  Leu Gly Lys Gly Ala  Ala Val Ile 
    1700                 1705                 1710             


Arg Ser  Arg Glu Pro Val Xaa  Leu Gly Ala Trp Xaa  Arg Val Ser 
    1715                 1720                 1725             


Leu Glu  Arg Asn Gly Arg Lys  Gly Ala Leu Arg Val  Gly Asp Gly 
    1730                 1735                 1740             


Pro Arg  Val Leu Gly Glu Ser  Pro Val Pro His Xaa  Val Leu Asn 
    1745                 1750                 1755             


Leu Lys  Glu Pro Leu Tyr Val  Gly Gly Ala Pro Asp  Phe Ser Lys 
    1760                 1765                 1770             


Leu Ala  Arg Ala Ala Ala Val  Ser Ser Gly Phe Asp  Gly Ala Ile 
    1775                 1780                 1785             


Gln Leu  Val Ser Leu Gly Gly  Arg Gln Leu Leu Xaa  Pro Glu His 
    1790                 1795                 1800             


Val Leu  Arg Gln Val Asp Val  Xaa Ser Phe Ala Gly  His Pro Cys 
    1805                 1810                 1815             


Xaa Arg  Ala Ser Gly His Pro  Cys Leu Asn Gly Ala  Ser Cys Val 
    1820                 1825                 1830             


Pro Arg  Glu Ala Ala Tyr Val  Cys Leu Cys Pro Gly  Gly Phe Ser 
    1835                 1840                 1845             


Gly Pro  His Cys Glu Lys Gly  Leu Val Glu Lys Ser  Ala Gly Asp 
    1850                 1855                 1860             


Val Asp  Xaa Leu Ala Phe Asp  Gly Arg Xaa Phe Val  Glu Tyr Leu 
    1865                 1870                 1875             


Asn Ala  Val Xaa Glu Ser Glu  Lys Ala Leu Gln Ser  Asn His Phe 
    1880                 1885                 1890             


Glu Leu  Ser Leu Arg Xaa Glu  Ala Xaa Gln Gly Leu  Val Leu Trp 
    1895                 1900                 1905             


Ser Gly  Lys Ala Xaa Glu Arg  Ala Asp Tyr Val Ala  Leu Ala Ile 
    1910                 1915                 1920             


Val Asp  Gly His Leu Gln Leu  Ser Tyr Asn Leu Gly  Ser Gln Pro 
    1925                 1930                 1935             


Val Val  Leu Arg Ser Xaa Val  Pro Val Asn Xaa Asn  Arg Trp Leu 
    1940                 1945                 1950             


Arg Val  Val Ala His Arg Glu  Gln Arg Glu Gly Ser  Leu Gln Val 
    1955                 1960                 1965             


Gly Asn  Glu Ala Pro Val Xaa  Gly Ser Ser Pro Leu  Gly Ala Xaa 
    1970                 1975                 1980             


Gln Leu  Asp Xaa Asp Gly Ala  Leu Trp Leu Gly Gly  Leu Pro Glu 
    1985                 1990                 1995             


Leu Pro  Val Gly Pro Ala Leu  Pro Lys Ala Tyr Gly  Xaa Gly Phe 
    2000                 2005                 2010             


Val Gly  Cys Leu Arg Asp Val  Val Val Gly Arg His  Pro Leu His 
    2015                 2020                 2025             


Leu Leu  Glu Asp Ala Val Xaa  Lys Pro Glu Leu Arg  Pro Cys Pro 
    2030                 2035                 2040             


Xaa Pro  
    2045 


<210> 1988
<211> 1930
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (873)..(873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1120)..(1120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1123)..(1123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1255)..(1255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1298)..(1298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1306)..(1306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1346)..(1346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1353)..(1353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1372)..(1372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1402)..(1402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1484)..(1484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1488)..(1488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1515)..(1515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1546)..(1546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1587)..(1587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1666)..(1666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1677)..(1677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1685)..(1685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1732)..(1732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1739)..(1739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1748)..(1748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1784)..(1784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1798)..(1798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1829)..(1829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1834)..(1834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1860)..(1860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1868)..(1868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1872)..(1872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1896)..(1896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1920)..(1920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1929)..(1929)
<223> Selenocysteine

<400> 1988
Met Arg Ile Xaa Leu Arg Asn Leu Glu Glu Val Glu Phe Cys Val Glu 
1               5                   10                  15      


Asp Lys Pro Gly Xaa His Phe Xaa Pro Val Pro Pro Xaa Pro Pro Asp 
            20                  25                  30          


Ala Cys Arg Gly Met Leu Cys Gly Phe Gly Ala Val Cys Glu Pro Asn 
        35                  40                  45              


Ala Glu Gly Pro Gly Arg Ala Ser Cys Val Cys Lys Lys Ser Pro Cys 
    50                  55                  60                  


Pro Ser Val Val Ala Pro Val Cys Gly Ser Asp Ala Ser Xaa Tyr Ser 
65                  70                  75                  80  


Asn Glu Cys Glu Leu Gln Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile 
                85                  90                  95      


Arg Leu Leu Ser Arg Gly Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn 
            100                 105                 110         


Val Xaa Cys Ser Phe Gly Ser Xaa Cys Ala Arg Ser Ala Asp Gly Leu 
        115                 120                 125             


Xaa Ala Ser Cys Leu Cys Pro Ala Xaa Cys Arg Gly Ala Pro Glu Gly 
    130                 135                 140                 


Xaa Val Cys Gly Ser Asp Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu 
145                 150                 155                 160 


Leu Arg Arg Ala Cys Ala Arg Gln Glu Asn Val Phe Lys Lys Phe Asp 
                165                 170                 175     


Gly Pro Cys Asp Pro Cys Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser 
            180                 185                 190         


Cys Arg Val Asn Pro Arg Xaa Arg Arg Pro Glu Met Leu Leu Arg Pro 
        195                 200                 205             


Glu Ser Cys Pro Ala Arg Gln Ala Pro Val Cys Gly Asp Asp Gly Val 
    210                 215                 220                 


Xaa Tyr Glu Asn Asp Cys Val Met Gly Arg Ser Gly Ala Ala Arg Gly 
225                 230                 235                 240 


Leu Leu Leu Gln Lys Val Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln 
                245                 250                 255     


Cys Pro Glu Pro Cys Arg Phe Asn Ala Val Cys Leu Ser Arg Arg Gly 
            260                 265                 270         


Arg Pro Arg Cys Ser Cys Asp Arg Val Xaa Cys Asp Gly Ala Tyr Arg 
        275                 280                 285             


Pro Val Cys Ala Gln Asp Gly Arg Xaa Tyr Asp Ser Asp Cys Trp Arg 
    290                 295                 300                 


Gln Gln Ala Glu Cys Arg Gln Gln Arg Ala Ile Pro Ser Lys His Gln 
305                 310                 315                 320 


Gly Pro Cys Asp Gln Ala Pro Ser Pro Cys Leu Gly Val Gln Cys Ala 
                325                 330                 335     


Phe Gly Ala Xaa Cys Ala Val Lys Asn Gly Gln Ala Ala Cys Glu Cys 
            340                 345                 350         


Leu Gln Ala Cys Ser Ser Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly 
        355                 360                 365             


Val Xaa Tyr Gly Ser Ala Cys Glu Leu Glu Ala Xaa Ala Cys Xaa Leu 
    370                 375                 380                 


Gly Arg Glu Ile Gln Val Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly 
385                 390                 395                 400 


Gln Cys Arg Phe Gly Ala Leu Cys Glu Ala Glu Xaa Gly Arg Cys Val 
                405                 410                 415     


Cys Pro Ser Glu Cys Val Ala Leu Ala Gln Pro Val Cys Gly Ser Asp 
            420                 425                 430         


Gly His Xaa Tyr Pro Ser Glu Cys Met Leu His Val His Ala Cys Xaa 
        435                 440                 445             


His Gln Ile Ser Leu His Val Ala Ser Ala Gly Pro Cys Glu Xaa Cys 
    450                 455                 460                 


Gly Asp Ala Val Cys Ala Phe Gly Ala Val Cys Ser Ala Gly Gln Cys 
465                 470                 475                 480 


Val Cys Pro Arg Cys Glu His Pro Pro Pro Gly Pro Val Cys Gly Ser 
                485                 490                 495     


Asp Gly Val Xaa Tyr Gly Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys 
            500                 505                 510         


Leu Gln Gln Xaa Gln Ile Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln 
        515                 520                 525             


Ala Glu Cys Gly Ser Gly Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys 
    530                 535                 540                 


Glu Gln Glu Leu Cys Arg Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser 
545                 550                 555                 560 


Glu Asp Gly Pro Cys Val Cys Asp Phe Ser Cys Gln Ser Val Pro Gly 
                565                 570                 575     


Ser Pro Val Cys Gly Ser Asp Gly Val Xaa Tyr Ser Xaa Glu Cys Glu 
            580                 585                 590         


Leu Lys Lys Ala Arg Cys Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala 
        595                 600                 605             


Gln Gly Ala Cys Arg Gly Pro Xaa Phe Ala Pro Leu Pro Pro Val Ala 
    610                 615                 620                 


Pro Leu His Cys Ala Gln Xaa Pro Tyr Gly Cys Cys Gln Asp Asn Ile 
625                 630                 635                 640 


Xaa Ala Ala Arg Gly Val Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln 
                645                 650                 655     


Cys Asn Pro His Gly Ser Tyr Gly Gly Xaa Cys Asp Pro Ala Xaa Gly 
            660                 665                 670         


Gln Cys Ser Cys Arg Pro Gly Val Gly Gly Leu Arg Cys Asp Arg Cys 
        675                 680                 685             


Glu Pro Gly Phe Trp Asn Phe Arg Gly Ile Val Xaa Asp Gly Arg Ser 
    690                 695                 700                 


Gly Cys Xaa Pro Cys Ser Cys Asp Pro Gln Gly Ala Val Arg Asp Asp 
705                 710                 715                 720 


Cys Glu Gln Met Xaa Gly Leu Cys Ser Cys Lys Pro Gly Val Ala Gly 
                725                 730                 735     


Pro Lys Cys Gly Gln Cys Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly 
            740                 745                 750         


Cys Glu Ala Asp Ala Ser Ala Pro Ala Xaa Cys Ala Glu Met Arg Cys 
        755                 760                 765             


Glu Phe Gly Ala Arg Cys Val Glu Glu Ser Gly Ser Ala His Cys Val 
    770                 775                 780                 


Cys Pro Met Leu Xaa Cys Pro Glu Ala Asn Ala Xaa Lys Val Cys Gly 
785                 790                 795                 800 


Ser Asp Gly Val Xaa Tyr Gly Asn Glu Cys Gln Leu Lys Xaa Ile Ala 
                805                 810                 815     


Cys Arg Gln Gly Leu Gln Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln 
            820                 825                 830         


Glu Ala Val Ala Pro Ser Xaa His Pro Xaa Ser Ala Ser Val Xaa Val 
        835                 840                 845             


Xaa Xaa Pro Gly Leu Leu Leu Ser Gln Ala Leu Pro Ala Pro Pro Gly 
    850                 855                 860                 


Ala Leu Pro Leu Ala Pro Ser Ser Xaa Ala His Ser Gln Xaa Xaa Pro 
865                 870                 875                 880 


Pro Pro Ser Ser Arg Pro Arg Xaa Xaa Ala Ser Val Pro Arg Xaa Xaa 
                885                 890                 895     


Val Trp Pro Val Leu Xaa Val Pro Pro Xaa Ala Pro Ser Pro Ala Pro 
            900                 905                 910         


Ser Leu Val Ala Ser Ala Phe Gly Glu Ser Gly Ser Xaa Asp Gly Ser 
        915                 920                 925             


Ser Asp Glu Glu Leu Ser Gly Asp Gln Glu Ala Ser Gly Gly Gly Ser 
    930                 935                 940                 


Gly Gly Leu Glu Pro Leu Glu Gly Ser Ser Val Ala Xaa Pro Gly Pro 
945                 950                 955                 960 


Pro Val Glu Arg Ala Ser Cys Tyr Asn Ser Ala Leu Gly Cys Cys Ser 
                965                 970                 975     


Asp Gly Lys Xaa Pro Ser Leu Asp Ala Glu Gly Ser Asn Cys Pro Ala 
            980                 985                 990         


Xaa Lys Val Phe Gln Gly Val Leu  Glu Leu Glu Gly Val  Glu Gly Gln 
        995                 1000                 1005             


Glu Leu  Phe Tyr Xaa Pro Glu  Met Ala Asp Pro Lys  Ser Glu Leu 
    1010                 1015                 1020             


Phe Gly  Glu Xaa Ala Arg Ser  Ile Glu Ser Xaa Leu  Asp Asp Leu 
    1025                 1030                 1035             


Phe Arg  Asn Ser Asp Val Lys  Lys Asp Phe Arg Ser  Val Arg Leu 
    1040                 1045                 1050             


Arg Asp  Leu Gly Pro Gly Lys  Ser Val Arg Ala Ile  Val Asp Val 
    1055                 1060                 1065             


His Phe  Asp Pro Xaa Xaa Ala  Phe Arg Ala Pro Asp  Val Ala Arg 
    1070                 1075                 1080             


Ala Leu  Leu Arg Gln Ile Gln  Val Ser Arg Arg Arg  Ser Leu Gly 
    1085                 1090                 1095             


Val Arg  Arg Pro Leu Gln Glu  His Val Arg Phe Met  Asp Phe Asp 
    1100                 1105                 1110             


Trp Phe  Pro Ala Phe Ile Xaa  Gly Ala Xaa Ser Gly  Ala Ile Ala 
    1115                 1120                 1125             


Ala Gly  Ala Xaa Ala Arg Ala  Xaa Xaa Ala Ser Arg  Leu Pro Ser 
    1130                 1135                 1140             


Ser Ala  Val Xaa Pro Arg Ala  Pro His Pro Ser His  Xaa Ser Gln 
    1145                 1150                 1155             


Pro Val  Ala Lys Xaa Xaa Ala  Ala Pro Xaa Xaa Arg  Arg Pro Pro 
    1160                 1165                 1170             


Xaa Xaa  Ala Pro Ser Arg Val  Pro Gly Arg Arg Pro  Pro Ala Pro 
    1175                 1180                 1185             


Gln Gln  Pro Pro Lys Pro Cys  Asp Ser Gln Pro Cys  Phe His Gly 
    1190                 1195                 1200             


Gly Xaa  Cys Gln Asp Trp Ala  Leu Gly Gly Gly Phe  Xaa Cys Ser 
    1205                 1210                 1215             


Cys Pro  Ala Gly Arg Gly Gly  Ala Val Cys Glu Lys  Val Leu Gly 
    1220                 1225                 1230             


Ala Pro  Val Pro Ala Phe Glu  Gly Arg Ser Phe Leu  Ala Phe Pro 
    1235                 1240                 1245             


Xaa Leu  Arg Ala Tyr His Xaa  Leu Arg Leu Ala Leu  Glu Phe Arg 
    1250                 1255                 1260             


Ala Leu  Glu Pro Gln Gly Leu  Leu Leu Tyr Asn Gly  Asn Ala Arg 
    1265                 1270                 1275             


Gly Lys  Asp Phe Leu Ala Leu  Ala Leu Leu Asp Gly  Arg Val Gln 
    1280                 1285                 1290             


Leu Arg  Phe Asp Xaa Gly Ser  Gly Pro Ala Val Leu  Xaa Ser Ala 
    1295                 1300                 1305             


Val Pro  Val Glu Pro Gly Gln  Trp His Arg Leu Glu  Leu Ser Arg 
    1310                 1315                 1320             


His Trp  Arg Arg Gly Xaa Leu  Ser Val Asp Gly Glu  Xaa Pro Val 
    1325                 1330                 1335             


Leu Gly  Glu Ser Pro Ser Gly  Xaa Asp Gly Leu Asn  Leu Asp Xaa 
    1340                 1345                 1350             


Asp Leu  Phe Val Gly Gly Val  Pro Glu Asp Gln Ala  Ala Val Ala 
    1355                 1360                 1365             


Leu Glu  Arg Xaa Phe Val Gly  Ala Gly Leu Arg Gly  Cys Ile Arg 
    1370                 1375                 1380             


Leu Leu  Asp Val Asn Asn Gln  Arg Leu Glu Leu Gly  Ile Gly Pro 
    1385                 1390                 1395             


Gly Ala  Ala Xaa Arg Gly Ser  Gly Val Gly Glu Cys  Gly Asp His 
    1400                 1405                 1410             


Pro Cys  Leu Pro Asn Pro Cys  His Gly Gly Ala Pro  Cys Gln Asn 
    1415                 1420                 1425             


Leu Glu  Ala Gly Arg Phe His  Cys Gln Cys Pro Pro  Gly Arg Val 
    1430                 1435                 1440             


Gly Pro  Xaa Cys Ala Asp Glu  Lys Ser Pro Cys Gln  Pro Asn Pro 
    1445                 1450                 1455             


Cys His  Gly Ala Ala Pro Cys  Arg Val Leu Pro Glu  Gly Gly Ala 
    1460                 1465                 1470             


Gln Cys  Glu Cys Pro Leu Gly  Arg Glu Gly Xaa Phe  Cys Gln Xaa 
    1475                 1480                 1485             


Ala Ser  Gly Gln Asp Gly Ser  Gly Pro Phe Leu Ala  Asp Phe Asn 
    1490                 1495                 1500             


Gly Phe  Ser His Leu Glu Leu  Arg Gly Leu His Xaa  Phe Ala Arg 
    1505                 1510                 1515             


Asp Leu  Gly Glu Lys Met Ala  Leu Glu Val Val Phe  Leu Ala Arg 
    1520                 1525                 1530             


Gly Pro  Ser Gly Leu Leu Leu  Tyr Asn Gly Gln Lys  Xaa Asp Gly 
    1535                 1540                 1545             


Lys Gly  Asp Phe Val Ser Leu  Ala Leu Arg Asp Arg  Arg Leu Glu 
    1550                 1555                 1560             


Phe Arg  Tyr Asp Leu Gly Lys  Gly Ala Ala Val Ile  Arg Ser Arg 
    1565                 1570                 1575             


Glu Pro  Val Xaa Leu Gly Ala  Trp Xaa Arg Val Ser  Leu Glu Arg 
    1580                 1585                 1590             


Asn Gly  Arg Lys Gly Ala Leu  Arg Val Gly Asp Gly  Pro Arg Val 
    1595                 1600                 1605             


Leu Gly  Glu Ser Pro Lys Ser  Arg Lys Val Pro His  Xaa Val Leu 
    1610                 1615                 1620             


Asn Leu  Lys Glu Pro Leu Tyr  Val Gly Gly Ala Pro  Asp Phe Ser 
    1625                 1630                 1635             


Lys Leu  Ala Arg Ala Ala Ala  Val Ser Ser Gly Phe  Asp Gly Ala 
    1640                 1645                 1650             


Ile Gln  Leu Val Ser Leu Gly  Gly Arg Gln Leu Leu  Xaa Pro Glu 
    1655                 1660                 1665             


His Val  Leu Arg Gln Val Asp  Val Xaa Ser Phe Ala  Gly His Pro 
    1670                 1675                 1680             


Cys Xaa  Arg Ala Ser Gly His  Pro Cys Leu Asn Gly  Ala Ser Cys 
    1685                 1690                 1695             


Val Pro  Arg Glu Ala Ala Tyr  Val Cys Leu Cys Pro  Gly Gly Phe 
    1700                 1705                 1710             


Ser Gly  Pro His Cys Glu Lys  Gly Leu Val Glu Lys  Ser Ala Gly 
    1715                 1720                 1725             


Asp Val  Asp Xaa Leu Ala Phe  Asp Gly Arg Xaa Phe  Val Glu Tyr 
    1730                 1735                 1740             


Leu Asn  Ala Val Xaa Glu Ser  Glu Leu Ala Asn Glu  Ile Pro Val 
    1745                 1750                 1755             


Pro Glu  Xaa Leu Asp Ser Gly  Ala Leu His Ser Glu  Lys Ala Leu 
    1760                 1765                 1770             


Gln Ser  Asn His Phe Glu Leu  Ser Leu Arg Xaa Glu  Ala Xaa Gln 
    1775                 1780                 1785             


Gly Leu  Val Leu Trp Ser Gly  Lys Ala Xaa Glu Arg  Ala Asp Tyr 
    1790                 1795                 1800             


Val Ala  Leu Ala Ile Val Asp  Gly His Leu Gln Leu  Ser Tyr Asn 
    1805                 1810                 1815             


Leu Gly  Ser Gln Pro Val Val  Leu Arg Ser Xaa Val  Pro Val Asn 
    1820                 1825                 1830             


Xaa Asn  Arg Trp Leu Arg Val  Val Ala His Arg Glu  Gln Arg Glu 
    1835                 1840                 1845             


Gly Ser  Leu Gln Val Gly Asn  Glu Ala Pro Val Xaa  Gly Ser Ser 
    1850                 1855                 1860             


Pro Leu  Gly Ala Xaa Gln Leu  Asp Xaa Asp Gly Ala  Leu Trp Leu 
    1865                 1870                 1875             


Gly Gly  Leu Pro Glu Leu Pro  Val Gly Pro Ala Leu  Pro Lys Ala 
    1880                 1885                 1890             


Tyr Gly  Xaa Gly Phe Val Gly  Cys Leu Arg Asp Val  Val Val Gly 
    1895                 1900                 1905             


Arg His  Pro Leu His Leu Leu  Glu Asp Ala Val Xaa  Lys Pro Glu 
    1910                 1915                 1920             


Leu Arg  Pro Cys Pro Xaa Pro  
    1925                 1930 


<210> 1989
<211> 271
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<400> 1989
Xaa Arg Tyr Asp Leu Gly Lys Gly Ala Ala Val Ile Arg Ser Arg Glu 
1               5                   10                  15      


Pro Val Xaa Leu Gly Ala Trp Xaa Arg Val Ser Leu Glu Arg Asn Gly 
            20                  25                  30          


Arg Lys Gly Ala Leu Arg Val Gly Asp Gly Pro Arg Val Leu Gly Glu 
        35                  40                  45              


Ser Pro Lys Ser Arg Lys Val Pro His Xaa Val Leu Asn Leu Lys Glu 
    50                  55                  60                  


Pro Leu Tyr Val Gly Gly Ala Pro Asp Phe Ser Lys Leu Ala Arg Ala 
65                  70                  75                  80  


Ala Ala Val Ser Ser Gly Phe Asp Gly Ala Ile Gln Leu Val Ser Leu 
                85                  90                  95      


Gly Gly Arg Gln Leu Leu Xaa Pro Glu His Val Leu Arg Gln Val Asp 
            100                 105                 110         


Val Xaa Ser Phe Ala Gly His Pro Cys Xaa Arg Ala Ser Gly His Pro 
        115                 120                 125             


Cys Leu Asn Gly Ala Ser Cys Val Pro Arg Glu Ala Ala Tyr Val Cys 
    130                 135                 140                 


Leu Cys Pro Gly Gly Phe Ser Gly Pro His Cys Glu Lys Gly Leu Val 
145                 150                 155                 160 


Glu Lys Ser Ala Gly Asp Val Asp Xaa Leu Ala Phe Asp Gly Arg Xaa 
                165                 170                 175     


Phe Val Glu Tyr Leu Asn Ala Val Xaa Glu Ser Glu Leu Ala Asn Glu 
            180                 185                 190         


Ile Pro Val Pro Glu Xaa Leu Asp Ser Gly Ala Leu His Ser Glu Lys 
        195                 200                 205             


Ala Leu Gln Ser Asn His Phe Glu Leu Ser Leu Arg Xaa Glu Ala Xaa 
    210                 215                 220                 


Gln Gly Leu Val Leu Trp Ser Gly Lys Ala Xaa Glu Arg Ala Asp Tyr 
225                 230                 235                 240 


Val Ala Leu Ala Ile Val Asp Gly His Leu Gln Leu Ser Tyr Asn Leu 
                245                 250                 255     


Gly Ser Gln Pro Val Val Leu Arg Ser Xaa Val Pro Val Asn Xaa 
            260                 265                 270     


<210> 1990
<211> 132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<400> 1990
Met Leu Xaa Ala Ala Val Leu Ser Cys Ala Leu Leu Leu Ala Leu Pro 
1               5                   10                  15      


Ala Xaa Arg Gly Ala Gln Met Gly Leu Ala Pro Met Glu Gly Ile Arg 
            20                  25                  30          


Arg Pro Asp Gln Ala Leu Leu Pro Glu Leu Pro Gly Leu Gly Leu Arg 
        35                  40                  45              


Ala Pro Leu Lys Lys Xaa Xaa Ala Glu Gln Ala Glu Glu Asp Leu Leu 
    50                  55                  60                  


Gln Glu Ala Gln Ala Leu Ala Glu Val Leu Asp Leu Gln Asp Arg Glu 
65                  70                  75                  80  


Pro Arg Ser Ser Arg Arg Cys Val Arg Leu His Glu Ser Cys Leu Gly 
                85                  90                  95      


Gln Gln Val Pro Cys Cys Asp Pro Cys Ala Xaa Cys Tyr Cys Arg Phe 
            100                 105                 110         


Phe Asn Ala Phe Cys Tyr Cys Arg Lys Leu Gly Xaa Ala Met Asn Pro 
        115                 120                 125             


Cys Ser Arg Xaa 
    130         


<210> 1991
<211> 485
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<400> 1991
Met Arg Lys Arg Ala Pro Gln Ser Glu Met Ala Pro Ala Gly Val Ser 
1               5                   10                  15      


Leu Arg Ala Xaa Ile Leu Cys Leu Leu Ala Trp Ala Gly Leu Ala Ala 
            20                  25                  30          


Gly Asp Arg Val Tyr Ile His Pro Phe His Leu Val Ile His Asn Glu 
        35                  40                  45              


Ser Xaa Cys Glu Gln Leu Ala Lys Ala Asn Ala Gly Lys Pro Lys Asp 
    50                  55                  60                  


Pro Xaa Phe Ile Pro Ala Pro Ile Gln Ala Lys Xaa Ser Pro Val Asp 
65                  70                  75                  80  


Glu Lys Ala Leu Gln Asp Gln Leu Val Leu Val Ala Ala Lys Leu Asp 
                85                  90                  95      


Xaa Glu Asp Lys Leu Arg Ala Ala Met Val Gly Met Leu Ala Asn Phe 
            100                 105                 110         


Leu Gly Phe Arg Ile Tyr Gly Met His Ser Glu Leu Trp Gly Val Val 
        115                 120                 125             


His Gly Ala Xaa Val Leu Ser Pro Xaa Ala Val Phe Gly Xaa Leu Ala 
    130                 135                 140                 


Ser Leu Tyr Leu Gly Ala Leu Asp His Xaa Ala Asp Arg Leu Gln Ala 
145                 150                 155                 160 


Ile Leu Gly Val Pro Trp Lys Asp Lys Asn Cys Xaa Ser Arg Leu Asp 
                165                 170                 175     


Ala His Lys Val Leu Ser Ala Leu Gln Ala Val Gln Gly Leu Leu Val 
            180                 185                 190         


Ala Gln Gly Arg Ala Asp Ser Gln Ala Gln Leu Leu Leu Ser Xaa Val 
        195                 200                 205             


Val Gly Val Phe Xaa Ala Pro Gly Leu His Leu Lys Gln Pro Phe Val 
    210                 215                 220                 


Gln Gly Leu Ala Leu Tyr Xaa Pro Val Val Leu Pro Arg Ser Leu Asp 
225                 230                 235                 240 


Phe Xaa Glu Leu Asp Val Ala Ala Glu Lys Ile Asp Arg Phe Met Gln 
                245                 250                 255     


Ala Val Xaa Gly Trp Lys Xaa Gly Cys Ser Leu Met Gly Ala Ser Val 
            260                 265                 270         


Asp Ser Xaa Leu Ala Phe Asn Xaa Tyr Val His Phe Gln Gly Lys Met 
        275                 280                 285             


Lys Gly Phe Ser Leu Leu Ala Glu Pro Gln Glu Phe Trp Val Asp Asn 
    290                 295                 300                 


Ser Xaa Ser Val Ser Val Pro Met Leu Ser Gly Met Gly Xaa Phe Gln 
305                 310                 315                 320 


His Trp Ser Asp Ile Gln Asp Asn Phe Ser Val Xaa Gln Val Pro Phe 
                325                 330                 335     


Xaa Glu Ser Ala Cys Leu Leu Leu Ile Gln Pro His Tyr Ala Ser Asp 
            340                 345                 350         


Leu Asp Lys Val Glu Gly Leu Xaa Phe Gln Gln Asn Ser Leu Asn Trp 
        355                 360                 365             


Met Lys Lys Leu Ser Pro Arg Xaa Ile His Leu Xaa Met Pro Gln Leu 
    370                 375                 380                 


Val Leu Gln Gly Ser Tyr Asp Leu Gln Asp Leu Leu Ala Gln Ala Glu 
385                 390                 395                 400 


Leu Pro Ala Ile Leu His Xaa Glu Leu Asn Leu Gln Lys Leu Ser Asn 
                405                 410                 415     


Asp Arg Ile Arg Val Gly Glu Val Leu Asn Ser Ile Phe Phe Glu Leu 
            420                 425                 430         


Glu Ala Asp Glu Arg Glu Pro Xaa Glu Ser Xaa Gln Gln Leu Asn Lys 
        435                 440                 445             


Pro Glu Val Leu Glu Val Xaa Leu Asn Arg Pro Phe Leu Phe Ala Val 
    450                 455                 460                 


Tyr Asp Gln Ser Ala Xaa Ala Leu His Phe Leu Gly Arg Val Ala Asn 
465                 470                 475                 480 


Pro Leu Ser Xaa Ala 
                485 


<210> 1992
<211> 359
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<400> 1992
Met Ile Leu Asn Ser Ser Xaa Glu Asp Gly Ile Lys Arg Ile Gln Asp 
1               5                   10                  15      


Asp Cys Pro Lys Ala Gly Arg His Asn Tyr Ile Phe Val Met Ile Pro 
            20                  25                  30          


Xaa Leu Tyr Ser Ile Ile Phe Val Val Gly Ile Phe Gly Asn Ser Leu 
        35                  40                  45              


Val Val Ile Val Ile Tyr Phe Tyr Met Lys Leu Lys Xaa Val Ala Ser 
    50                  55                  60                  


Val Phe Leu Leu Asn Leu Ala Leu Ala Asp Leu Cys Phe Leu Leu Xaa 
65                  70                  75                  80  


Leu Pro Leu Trp Ala Val Tyr Xaa Ala Met Glu Tyr Arg Trp Pro Phe 
                85                  90                  95      


Gly Asn Tyr Leu Cys Lys Ile Ala Ser Ala Ser Val Ser Phe Asn Leu 
            100                 105                 110         


Tyr Ala Ser Val Phe Leu Leu Xaa Cys Leu Ser Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Ile Val His Pro Met Lys Ser Arg Leu Arg Arg Xaa Met Leu Val 
    130                 135                 140                 


Ala Lys Val Xaa Cys Ile Ile Ile Trp Leu Leu Ala Gly Leu Ala Ser 
145                 150                 155                 160 


Leu Pro Ala Ile Ile His Arg Asn Val Phe Phe Ile Glu Asn Xaa Asn 
                165                 170                 175     


Ile Xaa Val Cys Ala Phe His Tyr Glu Ser Gln Asn Ser Xaa Leu Pro 
            180                 185                 190         


Ile Gly Leu Gly Leu Xaa Lys Asn Ile Leu Gly Phe Leu Phe Pro Phe 
        195                 200                 205             


Leu Ile Ile Leu Xaa Ser Tyr Xaa Leu Ile Trp Lys Ala Leu Lys Lys 
    210                 215                 220                 


Ala Tyr Glu Ile Gln Lys Asn Lys Pro Arg Asn Asp Asp Ile Phe Lys 
225                 230                 235                 240 


Ile Ile Met Ala Ile Val Leu Phe Phe Phe Phe Ser Trp Ile Pro His 
                245                 250                 255     


Gln Ile Phe Xaa Phe Leu Asp Val Leu Ile Gln Leu Gly Ile Ile Arg 
            260                 265                 270         


Asp Cys Arg Ile Ala Asp Ile Val Asp Xaa Ala Met Pro Ile Xaa Ile 
        275                 280                 285             


Cys Ile Ala Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe Tyr Gly Phe 
    290                 295                 300                 


Leu Gly Lys Lys Phe Lys Arg Tyr Phe Leu Gln Leu Leu Lys Tyr Ile 
305                 310                 315                 320 


Pro Pro Lys Ala Lys Ser His Ser Asn Leu Ser Xaa Lys Met Ser Xaa 
                325                 330                 335     


Leu Ser Tyr Arg Pro Ser Asp Asn Val Ser Ser Ser Xaa Lys Lys Pro 
            340                 345                 350         


Ala Pro Cys Phe Glu Val Glu 
        355                 


<210> 1993
<211> 394
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<400> 1993
Met Lys Lys Met Asn His Lys Ser Xaa Asp Ser Pro Lys Ala Pro Gln 
1               5                   10                  15      


Leu Arg Gly Gly Val Phe Asp Ile Val Phe Ala Xaa Asn Ser Xaa Gln 
            20                  25                  30          


Val Ile Lys Met Ile Leu Asn Ser Ser Xaa Glu Asp Gly Ile Lys Arg 
        35                  40                  45              


Ile Gln Asp Asp Cys Pro Lys Ala Gly Arg His Asn Tyr Ile Phe Val 
    50                  55                  60                  


Met Ile Pro Xaa Leu Tyr Ser Ile Ile Phe Val Val Gly Ile Phe Gly 
65                  70                  75                  80  


Asn Ser Leu Val Val Ile Val Ile Tyr Phe Tyr Met Lys Leu Lys Xaa 
                85                  90                  95      


Val Ala Ser Val Phe Leu Leu Asn Leu Ala Leu Ala Asp Leu Cys Phe 
            100                 105                 110         


Leu Leu Xaa Leu Pro Leu Trp Ala Val Tyr Xaa Ala Met Glu Tyr Arg 
        115                 120                 125             


Trp Pro Phe Gly Asn Tyr Leu Cys Lys Ile Ala Ser Ala Ser Val Ser 
    130                 135                 140                 


Phe Asn Leu Tyr Ala Ser Val Phe Leu Leu Xaa Cys Leu Ser Ile Asp 
145                 150                 155                 160 


Arg Tyr Leu Ala Ile Val His Pro Met Lys Ser Arg Leu Arg Arg Xaa 
                165                 170                 175     


Met Leu Val Ala Lys Val Xaa Cys Ile Ile Ile Trp Leu Leu Ala Gly 
            180                 185                 190         


Leu Ala Ser Leu Pro Ala Ile Ile His Arg Asn Val Phe Phe Ile Glu 
        195                 200                 205             


Asn Xaa Asn Ile Xaa Val Cys Ala Phe His Tyr Glu Ser Gln Asn Ser 
    210                 215                 220                 


Xaa Leu Pro Ile Gly Leu Gly Leu Xaa Lys Asn Ile Leu Gly Phe Leu 
225                 230                 235                 240 


Phe Pro Phe Leu Ile Ile Leu Xaa Ser Tyr Xaa Leu Ile Trp Lys Ala 
                245                 250                 255     


Leu Lys Lys Ala Tyr Glu Ile Gln Lys Asn Lys Pro Arg Asn Asp Asp 
            260                 265                 270         


Ile Phe Lys Ile Ile Met Ala Ile Val Leu Phe Phe Phe Phe Ser Trp 
        275                 280                 285             


Ile Pro His Gln Ile Phe Xaa Phe Leu Asp Val Leu Ile Gln Leu Gly 
    290                 295                 300                 


Ile Ile Arg Asp Cys Arg Ile Ala Asp Ile Val Asp Xaa Ala Met Pro 
305                 310                 315                 320 


Ile Xaa Ile Cys Ile Ala Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe 
                325                 330                 335     


Tyr Gly Phe Leu Gly Lys Lys Phe Lys Arg Tyr Phe Leu Gln Leu Leu 
            340                 345                 350         


Lys Tyr Ile Pro Pro Lys Ala Lys Ser His Ser Asn Leu Ser Xaa Lys 
        355                 360                 365             


Met Ser Xaa Leu Ser Tyr Arg Pro Ser Asp Asn Val Ser Ser Ser Xaa 
    370                 375                 380                 


Lys Lys Pro Ala Pro Cys Phe Glu Val Glu 
385                 390                 


<210> 1994
<211> 388
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<400> 1994
Met Leu Xaa Phe Xaa Ser Glu Cys Gly Cys Xaa Xaa Phe Gly Val Phe 
1               5                   10                  15      


Asp Ile Val Phe Ala Xaa Asn Ser Xaa Gln Val Ile Lys Met Ile Leu 
            20                  25                  30          


Asn Ser Ser Xaa Glu Asp Gly Ile Lys Arg Ile Gln Asp Asp Cys Pro 
        35                  40                  45              


Lys Ala Gly Arg His Asn Tyr Ile Phe Val Met Ile Pro Xaa Leu Tyr 
    50                  55                  60                  


Ser Ile Ile Phe Val Val Gly Ile Phe Gly Asn Ser Leu Val Val Ile 
65                  70                  75                  80  


Val Ile Tyr Phe Tyr Met Lys Leu Lys Xaa Val Ala Ser Val Phe Leu 
                85                  90                  95      


Leu Asn Leu Ala Leu Ala Asp Leu Cys Phe Leu Leu Xaa Leu Pro Leu 
            100                 105                 110         


Trp Ala Val Tyr Xaa Ala Met Glu Tyr Arg Trp Pro Phe Gly Asn Tyr 
        115                 120                 125             


Leu Cys Lys Ile Ala Ser Ala Ser Val Ser Phe Asn Leu Tyr Ala Ser 
    130                 135                 140                 


Val Phe Leu Leu Xaa Cys Leu Ser Ile Asp Arg Tyr Leu Ala Ile Val 
145                 150                 155                 160 


His Pro Met Lys Ser Arg Leu Arg Arg Xaa Met Leu Val Ala Lys Val 
                165                 170                 175     


Xaa Cys Ile Ile Ile Trp Leu Leu Ala Gly Leu Ala Ser Leu Pro Ala 
            180                 185                 190         


Ile Ile His Arg Asn Val Phe Phe Ile Glu Asn Xaa Asn Ile Xaa Val 
        195                 200                 205             


Cys Ala Phe His Tyr Glu Ser Gln Asn Ser Xaa Leu Pro Ile Gly Leu 
    210                 215                 220                 


Gly Leu Xaa Lys Asn Ile Leu Gly Phe Leu Phe Pro Phe Leu Ile Ile 
225                 230                 235                 240 


Leu Xaa Ser Tyr Xaa Leu Ile Trp Lys Ala Leu Lys Lys Ala Tyr Glu 
                245                 250                 255     


Ile Gln Lys Asn Lys Pro Arg Asn Asp Asp Ile Phe Lys Ile Ile Met 
            260                 265                 270         


Ala Ile Val Leu Phe Phe Phe Phe Ser Trp Ile Pro His Gln Ile Phe 
        275                 280                 285             


Xaa Phe Leu Asp Val Leu Ile Gln Leu Gly Ile Ile Arg Asp Cys Arg 
    290                 295                 300                 


Ile Ala Asp Ile Val Asp Xaa Ala Met Pro Ile Xaa Ile Cys Ile Ala 
305                 310                 315                 320 


Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe Tyr Gly Phe Leu Gly Lys 
                325                 330                 335     


Lys Phe Lys Arg Tyr Phe Leu Gln Leu Leu Lys Tyr Ile Pro Pro Lys 
            340                 345                 350         


Ala Lys Ser His Ser Asn Leu Ser Xaa Lys Met Ser Xaa Leu Ser Tyr 
        355                 360                 365             


Arg Pro Ser Asp Asn Val Ser Ser Ser Xaa Lys Lys Pro Ala Pro Cys 
    370                 375                 380                 


Phe Glu Val Glu 
385             


<210> 1995
<211> 363
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<400> 1995
Met Lys Gly Asn Ser Xaa Leu Ala Xaa Xaa Ser Lys Asn Ile Xaa Ser 
1               5                   10                  15      


Gly Leu His Phe Gly Leu Val Asn Ile Ser Gly Asn Asn Glu Ser Xaa 
            20                  25                  30          


Leu Asn Cys Ser Gln Lys Pro Ser Asp Lys His Leu Asp Ala Ile Pro 
        35                  40                  45              


Ile Leu Tyr Tyr Ile Ile Phe Val Ile Gly Phe Leu Val Asn Ile Val 
    50                  55                  60                  


Val Val Xaa Leu Phe Cys Cys Gln Lys Gly Pro Lys Lys Val Ser Ser 
65                  70                  75                  80  


Ile Tyr Ile Phe Asn Leu Ala Val Ala Asp Leu Leu Leu Leu Ala Xaa 
                85                  90                  95      


Leu Pro Leu Trp Ala Xaa Tyr Tyr Ser Tyr Arg Tyr Asp Trp Leu Phe 
            100                 105                 110         


Gly Pro Val Met Cys Lys Val Phe Gly Ser Phe Leu Xaa Leu Asn Met 
        115                 120                 125             


Phe Ala Ser Ile Phe Phe Ile Xaa Cys Met Ser Val Asp Arg Tyr Gln 
    130                 135                 140                 


Ser Val Ile Tyr Pro Phe Leu Ser Gln Arg Arg Asn Pro Trp Gln Ala 
145                 150                 155                 160 


Ser Tyr Ile Val Pro Leu Val Trp Cys Met Ala Cys Leu Ser Ser Leu 
                165                 170                 175     


Pro Xaa Phe Tyr Phe Arg Asp Val Arg Xaa Ile Glu Tyr Leu Gly Val 
            180                 185                 190         


Asn Ala Cys Ile Met Ala Phe Pro Pro Glu Lys Tyr Ala Gln Trp Ser 
        195                 200                 205             


Ala Gly Ile Ala Leu Met Lys Asn Ile Leu Gly Phe Ile Ile Pro Leu 
    210                 215                 220                 


Ile Phe Ile Ala Xaa Cys Tyr Phe Gly Ile Arg Lys His Leu Leu Lys 
225                 230                 235                 240 


Xaa Asn Ser Tyr Gly Lys Asn Arg Ile Xaa Arg Asp Gln Val Leu Lys 
                245                 250                 255     


Met Ala Ala Ala Val Val Leu Ala Phe Ile Ile Cys Trp Leu Pro Phe 
            260                 265                 270         


His Val Leu Xaa Phe Leu Asp Ala Leu Ala Trp Met Gly Val Ile Asn 
        275                 280                 285             


Ser Cys Glu Val Ile Ala Val Ile Asp Leu Ala Leu Pro Phe Ala Ile 
    290                 295                 300                 


Leu Leu Gly Phe Xaa Asn Ser Cys Val Asn Pro Phe Leu Tyr Cys Phe 
305                 310                 315                 320 


Val Gly Asn Arg Phe Gln Gln Lys Leu Arg Ser Val Phe Arg Val Pro 
                325                 330                 335     


Ile Xaa Trp Leu Gln Gly Lys Arg Glu Ser Met Ser Cys Arg Lys Ser 
            340                 345                 350         


Ser Ser Leu Arg Glu Met Glu Xaa Phe Val Ser 
        355                 360             


<210> 1996
<211> 159
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 1996
Met Glu Leu Pro Ala Val Asn Leu Lys Cys Ala Ser Ser Ser Val Pro 
1               5                   10                  15      


Arg Asn His Pro His Val Ile Leu Leu Gly His Trp Leu Leu Xaa Xaa 
            20                  25                  30          


Cys Phe Trp Arg His Phe Ser Ala Lys Pro Arg Leu Glu Xaa Ile Glu 
        35                  40                  45              


Leu Xaa Cys Ala Leu Cys Lys Leu Arg Ser Ala Ala His Arg Ala Xaa 
    50                  55                  60                  


Ala Gly Leu His Cys Ile Leu Arg Leu Leu Cys Leu Gly Gln Leu His 
65                  70                  75                  80  


His Pro Gly Leu Gly Arg Val Gly Cys Gly Ser Ala Gly Leu His Arg 
                85                  90                  95      


Arg His Lys His Val Ser Gly Trp Leu Ala Gly His His Leu Pro Gly 
            100                 105                 110         


His Arg Ala His Gln His Leu Leu Pro Ala Gly Gln Pro His Gly His 
        115                 120                 125             


Gly Pro Leu Trp Arg Gly His Gly His Pro Gln Leu Ala Ala Gln Ala 
    130                 135                 140                 


Ala Leu Leu Leu Leu Arg Leu Pro His Val Pro Gly Ala Arg Gly 
145                 150                 155                 


<210> 1997
<211> 111
<212> PRT
<213> Homo sapiens

<400> 1997
Met Glu Leu Pro Ala Val Asn Leu Lys Gly Leu His Cys Ile Leu Arg 
1               5                   10                  15      


Leu Leu Cys Leu Gly Gln Leu His His Pro Gly Leu Gly Arg Val Gly 
            20                  25                  30          


Cys Gly Ser Ala Gly Leu His Arg Arg His Lys His Val Ser Gly Trp 
        35                  40                  45              


Leu Ala Gly His His Leu Pro Gly His Arg Ala His Gln His Leu Leu 
    50                  55                  60                  


Pro Ala Gly Gln Pro His Gly His Gly Pro Leu Trp Arg Gly His Gly 
65                  70                  75                  80  


His Pro Gln Leu Ala Ala Gln Ala Ala Leu Leu Leu Leu Arg Leu Pro 
                85                  90                  95      


His Val Pro Gly Ala Arg Gly Phe Pro Trp Val Phe Ser Gly Pro 
            100                 105                 110     


<210> 1998
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 1998
Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu Gly His Trp 
1               5                   10                  15      


Leu Leu Xaa Xaa Cys Phe Trp Arg His Phe Ser Ala Lys Pro Arg Leu 
            20                  25                  30          


Glu Xaa Ile Glu Leu Xaa Cys Ala Leu Cys Lys Leu Arg Ser Ala Ala 
        35                  40                  45              


His Arg Ala Xaa Ala Gly Leu His Cys Ile Leu Arg Leu Leu Cys Leu 
    50                  55                  60                  


Gly Gln Leu His His Pro Gly Leu Gly Arg Val Gly Cys Gly Ser Ala 
65                  70                  75                  80  


Gly Leu His Arg Arg His Lys His Val Ser Gly Trp Leu Ala Gly His 
                85                  90                  95      


His Leu Pro Gly His Arg Ala His Gln His Leu Leu Pro Ala Gly Gln 
            100                 105                 110         


Pro His Gly His Gly Pro Leu Trp Arg Gly His Gly His Pro Gln Leu 
        115                 120                 125             


Ala Ala Gln Ala Ala Leu Leu Leu Leu Arg Leu Pro His Val Pro Gly 
    130                 135                 140                 


Ala Arg Gly 
145         


<210> 1999
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 1999
Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu Gly His Trp 
1               5                   10                  15      


Leu Leu Xaa Xaa Cys Phe Trp Arg His Phe Ser Ala Lys Pro Arg Leu 
            20                  25                  30          


Glu Xaa Ile Glu Leu Xaa Cys Ala Leu Cys Lys Leu Arg Ser Ala Ala 
        35                  40                  45              


His Arg Ala Xaa Ala Gly Leu His Cys Ile Leu Arg Leu Leu Cys Leu 
    50                  55                  60                  


Gly Gln Leu His His Pro Gly Leu Gly Arg Val Gly Cys Gly Ser Ala 
65                  70                  75                  80  


Gly Leu His Arg Arg His Lys His Val Ser Gly Trp Leu Ala Gly His 
                85                  90                  95      


His Leu Pro Gly His Arg Ala His Gln His Leu Leu Pro Ala Gly Gln 
            100                 105                 110         


Pro His Gly His Gly Pro Leu Trp Arg Gly His Gly His Pro Gln Leu 
        115                 120                 125             


Ala Ala Gln Ala Ala Leu Leu Leu Leu Arg Leu Pro His Val Pro Gly 
    130                 135                 140                 


Ala Arg Gly Phe Pro Trp Val Phe Ser Gly Pro 
145                 150                 155 


<210> 2000
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<400> 2000
Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu Gly His Trp 
1               5                   10                  15      


Leu Leu Xaa Xaa Cys Phe Trp Val Ala Cys Trp Pro Pro Ser Ser Trp 
            20                  25                  30          


Xaa Ser Cys Xaa Ser Ala Ser Ser Xaa Arg Gly Ser Ala Ser Arg Xaa 
        35                  40                  45              


Arg Ala Ala Leu Ala Trp Ala Trp Pro Ser Ser Ala Cys Cys Ser Ser 
    50                  55                  60                  


Arg Ser Pro Ala Ala Ser Ser Xaa Xaa Cys Xaa Gly Ser Ala Gly Val 
65                  70                  75                  80  


Ser Ser Trp Ser Xaa Leu Val Ser Leu Gly Leu Leu Arg Xaa Val Val 
                85                  90                  95      


Pro Xaa Arg Arg Leu Xaa Gln Gln Arg Arg Pro Gln Ile Pro Leu Gln 
            100                 105                 110         


Ser Gln Arg Ala Gly Val Lys Met Pro Glu Gly Xaa Glu Ala Ser His 
        115                 120                 125             


Ala Ala Pro Gly Pro Ala Pro Gly Leu Pro Arg Ala Trp Glu Val Val 
    130                 135                 140                 


Leu Gly Met Leu Leu Xaa Ser Val Ser Trp Xaa 
145                 150                 155 


<210> 2001
<211> 159
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<400> 2001
Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu Gly His Trp 
1               5                   10                  15      


Leu Leu Xaa Xaa Trp Gly Cys Ile Val Phe Ser Gly Ser Tyr Ala Trp 
            20                  25                  30          


Ala Asn Phe Xaa Ile Leu Ala Leu Gly Val Trp Ala Val Ala Gln Arg 
        35                  40                  45              


Asp Ser Ile Asp Ala Ile Ser Met Phe Leu Gly Gly Leu Leu Ala Xaa 
    50                  55                  60                  


Ile Phe Leu Asp Ile Val His Ile Ser Ile Phe Tyr Pro Arg Val Ser 
65                  70                  75                  80  


Leu Xaa Asp Xaa Gly Arg Phe Gly Val Gly Met Ala Ile Leu Ser Leu 
                85                  90                  95      


Leu Leu Lys Pro Leu Ser Cys Cys Phe Val Tyr His Met Tyr Arg Glu 
            100                 105                 110         


Arg Gly Gly Glu Leu Leu Val His Xaa Gly Phe Leu Gly Ser Ser Gln 
        115                 120                 125             


Asp Arg Ser Ala Tyr Gln Xaa Ile Asp Ser Ala Glu Ala Pro Ala Asp 
    130                 135                 140                 


Pro Phe Ala Val Pro Glu Gly Arg Ser Gln Asp Ala Arg Gly Tyr 
145                 150                 155                 


<210> 2002
<211> 152
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 2002
Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu Gly His Trp 
1               5                   10                  15      


Leu Leu Xaa Xaa Trp Gly Cys Ile Val Phe Ser Gly Ser Tyr Ala Trp 
            20                  25                  30          


Ala Asn Phe Xaa Ile Leu Ala Leu Gly Val Trp Ala Val Ala Gln Arg 
        35                  40                  45              


Asp Ser Ile Asp Ala Ile Ser Met Phe Leu Gly Gly Leu Leu Ala Xaa 
    50                  55                  60                  


Ile Phe Leu Asp Ile Val His Ile Ser Ile Phe Tyr Pro Arg Val Ser 
65                  70                  75                  80  


Leu Xaa Asp Xaa Gly Arg Phe Gly Val Gly Met Ala Ile Leu Ser Leu 
                85                  90                  95      


Leu Leu Lys Pro Leu Ser Cys Cys Phe Val Tyr His Met Tyr Arg Glu 
            100                 105                 110         


Arg Gly Gly Phe Leu Gly Ser Ser Gln Asp Arg Ser Ala Tyr Gln Xaa 
        115                 120                 125             


Ile Asp Ser Ala Glu Ala Pro Ala Asp Pro Phe Ala Val Pro Glu Gly 
    130                 135                 140                 


Arg Ser Gln Asp Ala Arg Gly Tyr 
145                 150         


<210> 2003
<211> 63
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<400> 2003
Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu Gly His Trp 
1               5                   10                  15      


Leu Leu Xaa Xaa Trp His Lys Asp Cys Xaa Pro Cys Arg Ser Trp Glu 
            20                  25                  30          


Gly Asp Val Glu Val Leu Ile Arg Ala Pro Gln Gly Leu Pro His Ser 
        35                  40                  45              


Glu Ala Ser Ala Leu Gln Leu Asp Phe His Leu Tyr His Leu Phe 
    50                  55                  60              


<210> 2004
<211> 392
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<400> 2004
Met Ala Ser His Lys Leu Leu Val Xaa Pro Pro Lys Ala Leu Leu Lys 
1               5                   10                  15      


Pro Leu Ser Ile Pro Asn Gln Leu Leu Leu Gly Pro Gly Pro Ser Asn 
            20                  25                  30          


Leu Pro Pro Arg Ile Met Ala Ala Gly Gly Leu Gln Met Ile Gly Ser 
        35                  40                  45              


Met Ser Lys Asp Met Tyr Gln Ile Met Asp Glu Ile Lys Glu Gly Ile 
    50                  55                  60                  


Gln Tyr Val Phe Gln Xaa Arg Asn Pro Leu Xaa Leu Val Ile Ser Gly 
65                  70                  75                  80  


Ser Gly His Cys Ala Leu Glu Ala Ala Leu Val Asn Val Leu Glu Pro 
                85                  90                  95      


Gly Asp Ser Phe Leu Val Gly Ala Asn Gly Ile Trp Gly Gln Arg Ala 
            100                 105                 110         


Val Asp Ile Gly Glu Arg Ile Gly Ala Arg Val His Pro Met Xaa Lys 
        115                 120                 125             


Asp Pro Gly Gly His Tyr Xaa Leu Gln Glu Val Glu Glu Gly Leu Ala 
    130                 135                 140                 


Gln His Lys Pro Val Leu Leu Phe Leu Xaa His Gly Glu Ser Ser Xaa 
145                 150                 155                 160 


Gly Val Leu Gln Pro Leu Asp Gly Phe Gly Glu Leu Cys His Arg Tyr 
                165                 170                 175     


Lys Cys Leu Leu Leu Val Asp Ser Val Ala Ser Leu Gly Gly Xaa Pro 
            180                 185                 190         


Leu Tyr Met Asp Arg Gln Gly Ile Asp Ile Leu Tyr Ser Gly Ser Gln 
        195                 200                 205             


Lys Ala Leu Asn Ala Pro Pro Gly Xaa Ser Leu Ile Ser Phe Ser Asp 
    210                 215                 220                 


Lys Ala Lys Lys Lys Met Tyr Ser Arg Lys Xaa Lys Pro Phe Ser Phe 
225                 230                 235                 240 


Tyr Leu Asp Ile Lys Trp Leu Ala Asn Phe Trp Gly Cys Asp Asp Gln 
                245                 250                 255     


Pro Arg Met Tyr His His Xaa Ile Pro Val Ile Ser Leu Tyr Ser Leu 
            260                 265                 270         


Arg Glu Ser Leu Ala Leu Ile Ala Glu Gln Gly Leu Glu Asn Ser Trp 
        275                 280                 285             


Arg Gln His Arg Glu Ala Ala Ala Tyr Leu His Gly Arg Leu Gln Ala 
    290                 295                 300                 


Leu Gly Leu Gln Leu Phe Val Lys Asp Pro Ala Leu Arg Leu Pro Xaa 
305                 310                 315                 320 


Val Xaa Xaa Val Ala Val Pro Ala Gly Tyr Asp Trp Arg Asp Ile Val 
                325                 330                 335     


Ser Tyr Val Ile Asp His Phe Asp Ile Glu Ile Met Gly Gly Leu Gly 
            340                 345                 350         


Pro Ser Xaa Gly Lys Val Leu Arg Ile Gly Leu Leu Gly Cys Asn Ala 
        355                 360                 365             


Xaa Arg Glu Asn Val Asp Arg Val Xaa Glu Ala Leu Arg Ala Ala Leu 
    370                 375                 380                 


Gln His Cys Pro Lys Lys Lys Leu 
385                 390         


<210> 2005
<211> 80
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<400> 2005
Glu Ser Gln Ser Gln Lys Arg Ser Leu His Ser Val Ser Glu Glu Arg 
1               5                   10                  15      


Xaa Asp Glu Met Xaa His Lys Glu Xaa Asn Glu Gln Glu Glu Arg Leu 
            20                  25                  30          


Leu Ala Xaa Ala Ser Phe Xaa Lys Ser Ser Arg Ser Ser Arg Xaa Arg 
        35                  40                  45              


Ser Ser Lys Ala Ile Leu Leu Pro Asp Leu Ser Glu Pro Asn Asn Glu 
    50                  55                  60                  


Pro Leu Phe Ser Pro Ala Ser Glu Val Pro Arg Lys Ala Lys Glu Arg 
65                  70                  75                  80  


<210> 2006
<211> 2275
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1184)..(1184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1238)..(1238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1276)..(1276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1322)..(1322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1342)..(1342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1354)..(1354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1357)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1361)..(1361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1364)..(1364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1378)..(1378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1394)..(1394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1416)..(1416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1432)..(1432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1449)..(1449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1451)..(1451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1475)..(1475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1526)..(1526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1559)..(1559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1602)..(1602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1629)..(1629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1631)..(1631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1655)..(1655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1665)..(1665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1688)..(1688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1694)..(1694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1697)..(1697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1705)..(1705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1717)..(1717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1726)..(1726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1730)..(1730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1732)..(1732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1734)..(1734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1748)..(1748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1750)..(1750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1785)..(1785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1817)..(1817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1835)..(1835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1845)..(1846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1866)..(1867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1877)..(1877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1880)..(1880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1904)..(1904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1906)..(1906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1918)..(1918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1926)..(1926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1969)..(1969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2019)..(2019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2022)..(2022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2058)..(2058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2061)..(2061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2078)..(2078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2082)..(2082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2086)..(2086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2096)..(2096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2100)..(2100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2108)..(2108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2174)..(2174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2193)..(2193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2204)..(2204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2207)..(2207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2214)..(2214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2247)..(2248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2251)..(2251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2253)..(2253)
<223> Selenocysteine

<400> 2006
Met Ala Ala Glu Arg Arg Cys Gly Ser Met Arg Asp Leu Arg Ala Gln 
1               5                   10                  15      


Val Xaa Ser Gly Leu Leu Pro Phe Pro Glu Val Xaa Leu Gln Ala Leu 
            20                  25                  30          


Gly Glu Asp Glu Ile Xaa Leu Glu Ser Val Leu Arg Gly Lys Phe Ala 
        35                  40                  45              


Ala Gly Lys Asn Gly Leu Ala Cys Leu Ala Cys Gly Pro Gln Leu Glu 
    50                  55                  60                  


Val Val Asn Ser Ile Xaa Gly Glu Arg Leu Ser Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Gly Val Asn Glu Gln Pro Pro Val Val Leu Ala Val Lys Glu Phe Ser 
                85                  90                  95      


Trp Gln Lys Arg Xaa Gly Leu Leu Ile Gly Leu Glu Glu Xaa Glu Gly 
            100                 105                 110         


Ser Val Leu Cys Leu Tyr Asp Leu Gly Ile Ser Lys Val Val Lys Ala 
        115                 120                 125             


Val Val Leu Pro Gly Arg Val Xaa Ala Ile Glu Pro Ile Ile Asn His 
    130                 135                 140                 


Gly Gly Ala Ser Ala Ser Xaa Gln His Leu His Pro Ser Leu Arg Trp 
145                 150                 155                 160 


Leu Phe Gly Val Ala Ala Val Val Xaa Asp Val Gly Gln Ile Leu Leu 
                165                 170                 175     


Val Asp Leu Cys Leu Asp Asp Leu Ser Cys Asn Gln Asn Glu Val Glu 
            180                 185                 190         


Ala Ser Asp Leu Glu Val Leu Xaa Gly Ile Pro Ala Glu Val Pro His 
        195                 200                 205             


Ile Arg Glu Ser Val Met Arg Gln Gly Arg His Leu Cys Phe Gln Leu 
    210                 215                 220                 


Val Ser Pro Xaa Gly Xaa Ala Val Ser Xaa Leu Ser Tyr Ile Ser Arg 
225                 230                 235                 240 


Xaa Asn Gln Leu Ala Val Gly Phe Ser Asp Gly Tyr Leu Ala Leu Trp 
                245                 250                 255     


Asn Met Lys Ser Met Lys Arg Glu Tyr Tyr Ile Gln Leu Glu Ser Gly 
            260                 265                 270         


Gln Val Pro Val Tyr Ala Val Xaa Phe Gln Glu Pro Glu Asn Asp Pro 
        275                 280                 285             


Arg Asn Cys Cys Tyr Leu Trp Ala Val Gln Ser Xaa Gln Asp Ser Glu 
    290                 295                 300                 


Gly Asp Val Leu Ser Leu His Leu Leu Gln Leu Ala Phe Gly Asn Arg 
305                 310                 315                 320 


Lys Cys Leu Ala Ser Gly Gln Ile Leu Tyr Glu Gly Leu Glu Tyr Cys 
                325                 330                 335     


Glu Glu Arg Tyr Xaa Leu Asp Leu Xaa Gly Gly Met Phe Pro Leu Arg 
            340                 345                 350         


Gly Gln Xaa Ser Asn Xaa Lys Leu Leu Gly Cys Gln Ser Ile Glu Lys 
        355                 360                 365             


Phe Arg Ser His Gly Asp Arg Glu Glu Gly Val Asn Glu Ala Leu Ser 
    370                 375                 380                 


Pro Asp Xaa Ser Val Ser Val Phe Xaa Trp Gln Val Asn Ile Tyr Gly 
385                 390                 395                 400 


Gln Gly Lys Pro Ser Val Tyr Leu Gly Leu Phe Asp Ile Asn Arg Trp 
                405                 410                 415     


Tyr His Ala Gln Met Pro Asp Ser Leu Arg Ser Gly Glu Tyr Leu His 
            420                 425                 430         


Asn Cys Ser Tyr Phe Ala Leu Trp Ser Leu Glu Ser Val Val Ser Arg 
        435                 440                 445             


Xaa Ser Pro His Gly Ile Leu Asp Ile Leu Val His Glu Arg Ser Leu 
    450                 455                 460                 


Asn Arg Gly Val Pro Pro Ser Tyr Pro Pro Pro Glu Gln Phe Phe Asn 
465                 470                 475                 480 


Pro Ser Xaa Tyr Asn Phe Asp Ala Xaa Cys Leu Leu Asn Ser Gly Val 
                485                 490                 495     


Val His Leu Xaa Cys Xaa Gly Phe Gln Lys Glu Xaa Leu Xaa Phe Leu 
            500                 505                 510         


Lys Lys Ser Gly Pro Ser Leu Asn Glu Leu Ile Pro Asp Gly Tyr Asn 
        515                 520                 525             


Arg Cys Leu Val Ala Gly Leu Leu Ser Pro Arg Phe Val Asp Val Gln 
    530                 535                 540                 


Pro Ser Ser Leu Ser Gln Glu Glu Gln Leu Glu Ala Ile Leu Ser Ala 
545                 550                 555                 560 


Ala Ile Gln Xaa Ser Ser Leu Gly Leu Leu Xaa Gly Tyr Ile Arg Arg 
                565                 570                 575     


Trp Ile Xaa Glu Glu Gln Pro Asn Ser Ala Xaa Asn Leu Arg Phe Val 
            580                 585                 590         


Leu Glu Trp Xaa Trp Asn Lys Val Val Leu Xaa Lys Glu Glu Phe Asp 
        595                 600                 605             


Arg Leu Cys Val Pro Leu Phe Asp Gly Ser Cys His Phe Met Asp Pro 
    610                 615                 620                 


Gln Xaa Ile Gln Ser Ile Gln Gln Cys Tyr Leu Leu Leu Ser Asn Leu 
625                 630                 635                 640 


Asn Ile Val Leu Ser Cys Phe Ala Ser Glu Ala Arg Glu Ile Xaa Glu 
                645                 650                 655     


Arg Gly Leu Ile Asp Leu Ser Asn Lys Phe Val Val Ser His Leu Ile 
            660                 665                 670         


Cys Gln Tyr Ala Gln Val Val Leu Trp Phe Ser His Ser Gly Leu Leu 
        675                 680                 685             


Pro Glu Gly Ile Asp Asp Ser Val Gln Leu Ser Arg Leu Cys Tyr Asn 
    690                 695                 700                 


Tyr Pro Val Ile Gln Asn Tyr Tyr Xaa Ser Arg Arg Gln Lys Phe Glu 
705                 710                 715                 720 


Arg Leu Ser Arg Gly Lys Trp Asn Pro Asp Cys Leu Met Ile Asp Gly 
                725                 730                 735     


Leu Val Ser Gln Leu Gly Glu Arg Ile Glu Lys Leu Trp Lys Arg Asp 
            740                 745                 750         


Glu Gly Gly Xaa Gly Lys Tyr Pro Pro Ala Ser Leu His Ala Val Leu 
        755                 760                 765             


Asp Met Tyr Leu Leu Asp Gly Val Xaa Glu Ala Ala Lys His Ser Ile 
    770                 775                 780                 


Xaa Ile Tyr Leu Leu Leu Asp Ile Met Tyr Ser Phe Pro Asn Lys Xaa 
785                 790                 795                 800 


Asp Xaa Pro Ile Glu Ser Phe Pro Xaa Val Phe Ala Ile Ser Trp Gly 
                805                 810                 815     


Gln Val Lys Leu Ile Gln Gly Phe Trp Leu Ile Asp His Asn Asp Tyr 
            820                 825                 830         


Glu Ser Gly Leu Asp Leu Leu Phe His Pro Ala Xaa Ala Lys Pro Leu 
        835                 840                 845             


Ser Trp Gln His Ser Lys Ile Ile Gln Ala Phe Met Ser Gln Gly Glu 
    850                 855                 860                 


His Arg Gln Ala Leu Arg Tyr Ile Gln Xaa Met Lys Pro Xaa Val Ser 
865                 870                 875                 880 


Ser Gly Asn Asp Val Ile Leu His Leu Xaa Val Leu Leu Phe Asn Arg 
                885                 890                 895     


Cys Met Val Glu Ala Trp Asn Phe Leu Arg Gln His Cys Asn Arg Leu 
            900                 905                 910         


Asn Ile Glu Glu Leu Leu Lys His Met Tyr Glu Val Cys Gln Glu Met 
        915                 920                 925             


Gly Leu Met Glu Asp Leu Leu Lys Leu Pro Phe Xaa Asp Xaa Glu Gln 
    930                 935                 940                 


Glu Cys Leu Val Lys Phe Leu Gln Ser Ser Ala Ser Val Gln Asn His 
945                 950                 955                 960 


Glu Phe Leu Leu Val His His Leu Gln Arg Ala Asn Tyr Val Pro Ala 
                965                 970                 975     


Leu Lys Leu Asn Gln Xaa Leu Lys Ile Asn Val Met Asn Asp Arg Asp 
            980                 985                 990         


Pro Arg Leu Arg Glu Arg Ser Leu  Ala Arg Asn Ser Ile  Leu Asp Gln 
        995                 1000                 1005             


Tyr Gly  Lys Ile Leu Pro Arg  Val His Arg Lys Leu  Ala Ile Glu 
    1010                 1015                 1020             


Arg Ala  Lys Pro Tyr His Leu  Ser Xaa Ser Ser Val  Phe Arg Leu 
    1025                 1030                 1035             


Val Ser  Arg Pro Lys Pro Leu  Ser Ala Val Pro Lys  Gln Val Val 
    1040                 1045                 1050             


Xaa Gly  Xaa Val Leu Xaa Arg  Ser Val Phe Ile Asn  Asn Val Leu 
    1055                 1060                 1065             


Ser Lys  Ile Gly Glu Val Trp  Ala Ser Lys Glu Pro  Ile Asn Ser 
    1070                 1075                 1080             


Xaa Xaa  Pro Phe Asn Ser Ser  Lys Ile Glu Glu Pro  Ser Pro Ile 
    1085                 1090                 1095             


Val Tyr  Ser Leu Pro Ala Pro  Glu Leu Pro Glu Ala  Phe Phe Gly 
    1100                 1105                 1110             


Xaa Pro  Ile Ser Lys Ala Ser  Gln Lys Ile Ser Arg  Leu Leu Asp 
    1115                 1120                 1125             


Leu Val  Val Gln Pro Val Pro  Arg Pro Ser Gln Cys  Ser Glu Phe 
    1130                 1135                 1140             


Ile Gln  Gln Ser Ser Met Lys  Ser Pro Leu Tyr Leu  Val Ser Arg 
    1145                 1150                 1155             


Ser Leu  Pro Ser Ser Ser Gln  Leu Lys Gly Ser Pro  Gln Ala Ile 
    1160                 1165                 1170             


Ser Arg  Ala Ser Glu Leu His  Leu Leu Glu Xaa Pro  Leu Val Val 
    1175                 1180                 1185             


Lys Lys  Ala Lys Ser Leu Ala  Met Ser Val Xaa Xaa  Ser Gly Phe 
    1190                 1195                 1200             


Ser Glu  Phe Xaa Pro Gln Ser  Ile Leu Arg Ser Xaa  Leu Arg Ser 
    1205                 1210                 1215             


Xaa Pro  Leu Ala Ser Pro Ser  Pro Ser Pro Gly Arg  Ser Pro Gln 
    1220                 1225                 1230             


Arg Leu  Lys Glu Xaa Arg Ile  Ser Phe Val Glu Glu  Asp Val His 
    1235                 1240                 1245             


Pro Lys  Trp Ile Pro Gly Ala  Ala Asp Asp Ser Lys  Leu Glu Val 
    1250                 1255                 1260             


Phe Xaa  Xaa Pro Lys Lys Cys  Ala Val Pro Val Glu  Xaa Glu Trp 
    1265                 1270                 1275             


Leu Lys  Ser Lys Asp Arg Xaa  Xaa Ser Phe Phe Leu  Asn Ser Pro 
    1280                 1285                 1290             


Glu Lys  Glu His Gln Glu Met  Asp Glu Gly Ser Gln  Ser Leu Glu 
    1295                 1300                 1305             


Lys Leu  Asp Val Ser Lys Gly  Asn Ser Ser Val Ser  Ile Xaa Ser 
    1310                 1315                 1320             


Asp Glu  Xaa Xaa Leu Glu Tyr  Gln Asp Ala Pro Ser  Pro Glu Asp 
    1325                 1330                 1335             


Leu Glu  Glu Xaa Val Phe Xaa  Ala Ser Lys Pro Lys  Ser Ser Ser 
    1340                 1345                 1350             


Xaa Ala  Leu Xaa Xaa Asn Val  Xaa Glu Gln Xaa Glu  Lys Asp Gly 
    1355                 1360                 1365             


Asp Lys  Asp Val Phe Ala Ser  Glu Val Xaa Pro Ser  Asp Leu Gln 
    1370                 1375                 1380             


Lys Gln  Met Gly Asn Leu Glu  Asp Ala Glu Xaa Lys  Asp Leu Leu 
    1385                 1390                 1395             


Val Ala  Ala Glu Ala Phe Ser  Glu Leu Asn His Leu  Ser Pro Val 
    1400                 1405                 1410             


Gln Gly  Xaa Glu Ala Ser Leu  Cys Ala Pro Ser Val  Tyr Glu Gly 
    1415                 1420                 1425             


Lys Ile  Phe Xaa Gln Lys Ser  Lys Val Pro Val Leu  Asp Glu Gly 
    1430                 1435                 1440             


Leu Xaa  Ser Val Glu Xaa Tyr  Xaa Pro Ala Ile Arg  Ala Asn Asp 
    1445                 1450                 1455             


Asn Lys  Ser Met Ala Asp Val  Leu Gly Asp Gly Gly  Asn Ser Ser 
    1460                 1465                 1470             


Leu Xaa  Ile Ser Glu Gly Pro  Ile Val Ser Glu Arg  Arg Leu Asn 
    1475                 1480                 1485             


Gln Glu  Val Ala Leu Asn Leu  Lys Glu Asp His Glu  Val Glu Val 
    1490                 1495                 1500             


Gly Val  Leu Lys Glu Ser Val  Asp Leu Pro Glu Glu  Lys Leu Pro 
    1505                 1510                 1515             


Ile Ser  Asp Ser Pro Pro Asp  Xaa Gln Glu Ile His  Val Ile Glu 
    1520                 1525                 1530             


Gln Glu  Lys Leu Glu Ala Gln  Asp Ser Gly Glu Glu  Ala Arg Asn 
    1535                 1540                 1545             


Leu Ser  Phe Asn Glu Leu Tyr  Pro Ser Gly Xaa Leu  Lys Leu Gln 
    1550                 1555                 1560             


Tyr Asn  Phe Asp Xaa Ile Asp  Gln Gln Phe Cys Asp  Leu Ala Asp 
    1565                 1570                 1575             


Asn Lys  Asp Xaa Ala Glu Cys  Asp Ile Ala Glu Val  Asp Gly Glu 
    1580                 1585                 1590             


Leu Phe  Val Ala Gln Ser Asn  Phe Xaa Leu Ile Leu  Glu Gly Glu 
    1595                 1600                 1605             


Glu Gly  Glu Val Glu Pro Gly  Asp Phe Ala Ser Ser  Asp Val Leu 
    1610                 1615                 1620             


Pro Lys  Ala Ala Asn Xaa Ala  Xaa Glu Glu Lys Leu  Val Cys Ser 
    1625                 1630                 1635             


Gly Glu  Asn Asp Asn His Gly  Gln Ile Ala Asn Leu  Pro Ser Ala 
    1640                 1645                 1650             


Val Xaa  Ser Asp Gln Lys Ser  Gln Lys Val Asp Xaa  Leu Pro Tyr 
    1655                 1660                 1665             


Val Pro  Glu Pro Ile Lys Val  Ala Ile Ala Glu Asn  Leu Leu Asp 
    1670                 1675                 1680             


Val Ile  Lys Asp Xaa Arg Ser  Lys Glu Ile Xaa Ser  Asp Xaa Met 
    1685                 1690                 1695             


Glu Gln  Ser Ile His Glu Xaa  Ile Pro Leu Val Ser  Gln Asn Ile 
    1700                 1705                 1710             


Met Cys  Pro Xaa Lys Leu Val  Lys Ser Ala Phe Lys  Xaa Ala Gln 
    1715                 1720                 1725             


Glu Xaa  Ser Xaa Met Xaa Met  Asn Val Ser Gln Val  Asp Asp Val 
    1730                 1735                 1740             


Val Ser  Ser Lys Xaa Arg Xaa  Arg Gly Gln Arg Ile  Gln Asn Val 
    1745                 1750                 1755             


Asn Val  Lys Ser Ala Gln Gln  Glu Ala Ser Ala Asp  Val Ala Xaa 
    1760                 1765                 1770             


Pro Lys  Met Pro Gly Gln Ser  Val Arg Lys Lys Xaa  Arg Lys Ala 
    1775                 1780                 1785             


Lys Glu  Ile Ser Glu Ala Ser  Glu Asn Ile Tyr Ser  Asp Val Arg 
    1790                 1795                 1800             


Gly Leu  Ser Gln Asn Gln Gln  Ile Pro Gln Asn Ser  Val Xaa Pro 
    1805                 1810                 1815             


Arg Arg  Gly Arg Arg Lys Lys  Glu Val Asn Gln Asp  Ile Leu Glu 
    1820                 1825                 1830             


Asn Xaa  Ser Ser Val Glu Gln  Glu Leu Gln Ile Xaa  Xaa Gly Arg 
    1835                 1840                 1845             


Glu Ser  Lys Arg Leu Lys Ser  Ser Gln Leu Leu Glu  Pro Ala Val 
    1850                 1855                 1860             


Glu Glu  Xaa Xaa Lys Lys Glu  Val Lys Val Ser Ser  Val Xaa Lys 
    1865                 1870                 1875             


Arg Xaa  Pro Arg Arg Ile Lys  Arg Ser Val Glu Asn  Gln Glu Ser 
    1880                 1885                 1890             


Val Glu  Ile Ile Asn Asp Leu  Lys Val Ser Xaa Val  Xaa Ser Pro 
    1895                 1900                 1905             


Ser Arg  Met Ile Arg Lys Leu  Arg Ser Xaa Asn Leu  Asp Ala Ser 
    1910                 1915                 1920             


Glu Asn  Xaa Gly Asn Lys Gln  Asp Asp Lys Ser Ser  Asp Lys Gln 
    1925                 1930                 1935             


Leu Arg  Ile Lys His Val Arg  Arg Val Arg Gly Arg  Glu Val Ser 
    1940                 1945                 1950             


Pro Ser  Asp Val Arg Glu Asp  Ser Asn Leu Glu Ser  Ser Gln Leu 
    1955                 1960                 1965             


Xaa Val  Gln Ala Glu Phe Asp  Met Ser Ala Ile Pro  Arg Lys Arg 
    1970                 1975                 1980             


Gly Arg  Pro Arg Lys Ile Asn  Pro Ser Glu Asp Val  Gly Ser Lys 
    1985                 1990                 1995             


Ala Val  Lys Glu Glu Arg Ser  Pro Lys Lys Lys Glu  Ala Pro Ser 
    2000                 2005                 2010             


Ile Arg  Arg Arg Ser Xaa Arg  Asn Xaa Pro Ala Lys  Ser Glu Asn 
    2015                 2020                 2025             


Val Asp  Val Gly Lys Pro Ala  Leu Gly Lys Ser Ile  Leu Val Pro 
    2030                 2035                 2040             


Asn Glu  Glu Leu Ser Met Val  Met Ser Ser Lys Lys  Lys Leu Xaa 
    2045                 2050                 2055             


Lys Lys  Xaa Glu Ser Gln Ser  Gln Lys Arg Ser Leu  His Ser Val 
    2060                 2065                 2070             


Ser Glu  Glu Arg Xaa Asp Glu  Met Xaa His Lys Glu  Xaa Asn Glu 
    2075                 2080                 2085             


Gln Glu  Glu Arg Leu Leu Ala  Xaa Ala Ser Phe Xaa  Lys Ser Ser 
    2090                 2095                 2100             


Arg Ser  Ser Arg Xaa Arg Ser  Ser Lys Ala Ile Leu  Leu Pro Asp 
    2105                 2110                 2115             


Leu Ser  Glu Pro Asn Asn Glu  Pro Leu Phe Ser Pro  Ala Ser Glu 
    2120                 2125                 2130             


Val Pro  Arg Lys Ala Lys Ala  Lys Lys Ile Glu Val  Pro Ala Gln 
    2135                 2140                 2145             


Leu Lys  Glu Leu Val Ser Asp  Leu Ser Ser Gln Phe  Val Ile Ser 
    2150                 2155                 2160             


Pro Pro  Ala Leu Arg Ser Arg  Gln Lys Asn Xaa Ser  Asn Lys Asn 
    2165                 2170                 2175             


Lys Leu  Glu Asp Glu Leu Lys  Asp Asp Ala Gln Ser  Val Glu Xaa 
    2180                 2185                 2190             


Leu Gly  Lys Pro Lys Ala Lys  Arg Ile Arg Xaa Ser  Lys Xaa Lys 
    2195                 2200                 2205             


Gln Ala  Ser Lys Asn Xaa Glu  Lys Glu Ser Ala Trp  Ser Pro Pro 
    2210                 2215                 2220             


Pro Ile  Glu Ile Arg Leu Ile  Ser Pro Leu Ala Ser  Pro Ala Asp 
    2225                 2230                 2235             


Gly Val  Lys Ser Lys Pro Arg  Lys Xaa Xaa Glu Val  Xaa Gly Xaa 
    2240                 2245                 2250             


Gly Leu  Gly Arg Asn Arg Lys  Lys Leu Ser Ser Tyr  Pro Lys Gln 
    2255                 2260                 2265             


Ile Leu  Arg Arg Lys Met Leu  
    2270                 2275 


<210> 2007
<211> 2301
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1058)..(1058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1245)..(1245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1291)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1368)..(1368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1380)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1383)..(1384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1387)..(1387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1442)..(1442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1471)..(1471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1475)..(1475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1477)..(1477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1501)..(1501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1552)..(1552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1585)..(1585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1608)..(1608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1628)..(1628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1655)..(1655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1681)..(1681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1691)..(1691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1714)..(1714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1720)..(1720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1723)..(1723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1731)..(1731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1743)..(1743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1752)..(1752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1756)..(1756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1758)..(1758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1774)..(1774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1776)..(1776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1799)..(1799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1811)..(1811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1843)..(1843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1861)..(1861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1871)..(1872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1892)..(1893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1903)..(1903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1906)..(1906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1930)..(1930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1932)..(1932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1944)..(1944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1952)..(1952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1995)..(1995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2045)..(2045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2048)..(2048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2084)..(2084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2087)..(2087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2104)..(2104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2108)..(2108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2112)..(2112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2122)..(2122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2126)..(2126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2134)..(2134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2200)..(2200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2219)..(2219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2230)..(2230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2233)..(2233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2240)..(2240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2273)..(2274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2277)..(2277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2279)..(2279)
<223> Selenocysteine

<400> 2007
Met Asp Ser Leu Ala Gly Leu Ser Pro Arg Glu Ala Ala Gly Val Leu 
1               5                   10                  15      


Ser Leu Ser Cys Val Gly Val Cys Ser Xaa Cys Ala Trp Ala Trp Pro 
            20                  25                  30          


His Gly Ser Met Arg Asp Leu Arg Ala Gln Val Xaa Ser Gly Leu Leu 
        35                  40                  45              


Pro Phe Pro Glu Val Xaa Leu Gln Ala Leu Gly Glu Asp Glu Ile Xaa 
    50                  55                  60                  


Leu Glu Ser Val Leu Arg Gly Lys Phe Ala Ala Gly Lys Asn Gly Leu 
65                  70                  75                  80  


Ala Cys Leu Ala Cys Gly Pro Gln Leu Glu Val Val Asn Ser Ile Xaa 
                85                  90                  95      


Gly Glu Arg Leu Ser Ala Tyr Arg Phe Ser Gly Val Asn Glu Gln Pro 
            100                 105                 110         


Pro Val Val Leu Ala Val Lys Glu Phe Ser Trp Gln Lys Arg Xaa Gly 
        115                 120                 125             


Leu Leu Ile Gly Leu Glu Glu Xaa Glu Gly Ser Val Leu Cys Leu Tyr 
    130                 135                 140                 


Asp Leu Gly Ile Ser Lys Val Val Lys Ala Val Val Leu Pro Gly Arg 
145                 150                 155                 160 


Val Xaa Ala Ile Glu Pro Ile Ile Asn His Gly Gly Ala Ser Ala Ser 
                165                 170                 175     


Xaa Gln His Leu His Pro Ser Leu Arg Trp Leu Phe Gly Val Ala Ala 
            180                 185                 190         


Val Val Xaa Asp Val Gly Gln Ile Leu Leu Val Asp Leu Cys Leu Asp 
        195                 200                 205             


Asp Leu Ser Cys Asn Gln Asn Glu Val Glu Ala Ser Asp Leu Glu Val 
    210                 215                 220                 


Leu Xaa Gly Ile Pro Ala Glu Val Pro His Ile Arg Glu Ser Val Met 
225                 230                 235                 240 


Arg Gln Gly Arg His Leu Cys Phe Gln Leu Val Ser Pro Xaa Gly Xaa 
                245                 250                 255     


Ala Val Ser Xaa Leu Ser Tyr Ile Ser Arg Xaa Asn Gln Leu Ala Val 
            260                 265                 270         


Gly Phe Ser Asp Gly Tyr Leu Ala Leu Trp Asn Met Lys Ser Met Lys 
        275                 280                 285             


Arg Glu Tyr Tyr Ile Gln Leu Glu Ser Gly Gln Val Pro Val Tyr Ala 
    290                 295                 300                 


Val Xaa Phe Gln Glu Pro Glu Asn Asp Pro Arg Asn Cys Cys Tyr Leu 
305                 310                 315                 320 


Trp Ala Val Gln Ser Xaa Gln Asp Ser Glu Gly Asp Val Leu Ser Leu 
                325                 330                 335     


His Leu Leu Gln Leu Ala Phe Gly Asn Arg Lys Cys Leu Ala Ser Gly 
            340                 345                 350         


Gln Ile Leu Tyr Glu Gly Leu Glu Tyr Cys Glu Glu Arg Tyr Xaa Leu 
        355                 360                 365             


Asp Leu Xaa Gly Gly Met Phe Pro Leu Arg Gly Gln Xaa Ser Asn Xaa 
    370                 375                 380                 


Lys Leu Leu Gly Cys Gln Ser Ile Glu Lys Phe Arg Ser His Gly Asp 
385                 390                 395                 400 


Arg Glu Glu Gly Val Asn Glu Ala Leu Ser Pro Asp Xaa Ser Val Ser 
                405                 410                 415     


Val Phe Xaa Trp Gln Val Asn Ile Tyr Gly Gln Gly Lys Pro Ser Val 
            420                 425                 430         


Tyr Leu Gly Leu Phe Asp Ile Asn Arg Trp Tyr His Ala Gln Met Pro 
        435                 440                 445             


Asp Ser Leu Arg Ser Gly Glu Tyr Leu His Asn Cys Ser Tyr Phe Ala 
    450                 455                 460                 


Leu Trp Ser Leu Glu Ser Val Val Ser Arg Xaa Ser Pro His Gly Ile 
465                 470                 475                 480 


Leu Asp Ile Leu Val His Glu Arg Ser Leu Asn Arg Gly Val Pro Pro 
                485                 490                 495     


Ser Tyr Pro Pro Pro Glu Gln Phe Phe Asn Pro Ser Xaa Tyr Asn Phe 
            500                 505                 510         


Asp Ala Xaa Cys Leu Leu Asn Ser Gly Val Val His Leu Xaa Cys Xaa 
        515                 520                 525             


Gly Phe Gln Lys Glu Xaa Leu Xaa Phe Leu Lys Lys Ser Gly Pro Ser 
    530                 535                 540                 


Leu Asn Glu Leu Ile Pro Asp Gly Tyr Asn Arg Cys Leu Val Ala Gly 
545                 550                 555                 560 


Leu Leu Ser Pro Arg Phe Val Asp Val Gln Pro Ser Ser Leu Ser Gln 
                565                 570                 575     


Glu Glu Gln Leu Glu Ala Ile Leu Ser Ala Ala Ile Gln Xaa Ser Ser 
            580                 585                 590         


Leu Gly Leu Leu Xaa Gly Tyr Ile Arg Arg Trp Ile Xaa Glu Glu Gln 
        595                 600                 605             


Pro Asn Ser Ala Xaa Asn Leu Arg Phe Val Leu Glu Trp Xaa Trp Asn 
    610                 615                 620                 


Lys Val Val Leu Xaa Lys Glu Glu Phe Asp Arg Leu Cys Val Pro Leu 
625                 630                 635                 640 


Phe Asp Gly Ser Cys His Phe Met Asp Pro Gln Xaa Ile Gln Ser Ile 
                645                 650                 655     


Gln Gln Cys Tyr Leu Leu Leu Ser Asn Leu Asn Ile Val Leu Ser Cys 
            660                 665                 670         


Phe Ala Ser Glu Ala Arg Glu Ile Xaa Glu Arg Gly Leu Ile Asp Leu 
        675                 680                 685             


Ser Asn Lys Phe Val Val Ser His Leu Ile Cys Gln Tyr Ala Gln Val 
    690                 695                 700                 


Val Leu Trp Phe Ser His Ser Gly Leu Leu Pro Glu Gly Ile Asp Asp 
705                 710                 715                 720 


Ser Val Gln Leu Ser Arg Leu Cys Tyr Asn Tyr Pro Val Ile Gln Asn 
                725                 730                 735     


Tyr Tyr Xaa Ser Arg Arg Gln Lys Phe Glu Arg Leu Ser Arg Gly Lys 
            740                 745                 750         


Trp Asn Pro Asp Cys Leu Met Ile Asp Gly Leu Val Ser Gln Leu Gly 
        755                 760                 765             


Glu Arg Ile Glu Lys Leu Trp Lys Arg Asp Glu Gly Gly Xaa Gly Lys 
    770                 775                 780                 


Tyr Pro Pro Ala Ser Leu His Ala Val Leu Asp Met Tyr Leu Leu Asp 
785                 790                 795                 800 


Gly Val Xaa Glu Ala Ala Lys His Ser Ile Xaa Ile Tyr Leu Leu Leu 
                805                 810                 815     


Asp Ile Met Tyr Ser Phe Pro Asn Lys Xaa Asp Xaa Pro Ile Glu Ser 
            820                 825                 830         


Phe Pro Xaa Val Phe Ala Ile Ser Trp Gly Gln Val Lys Leu Ile Gln 
        835                 840                 845             


Gly Phe Trp Leu Ile Asp His Asn Asp Tyr Glu Ser Gly Leu Asp Leu 
    850                 855                 860                 


Leu Phe His Pro Ala Xaa Ala Lys Pro Leu Ser Trp Gln His Ser Lys 
865                 870                 875                 880 


Ile Ile Gln Ala Phe Met Ser Gln Gly Glu His Arg Gln Ala Leu Arg 
                885                 890                 895     


Tyr Ile Gln Xaa Met Lys Pro Xaa Val Ser Ser Gly Asn Asp Val Ile 
            900                 905                 910         


Leu His Leu Xaa Val Leu Leu Phe Asn Arg Cys Met Val Glu Ala Trp 
        915                 920                 925             


Asn Phe Leu Arg Gln His Cys Asn Arg Leu Asn Ile Glu Glu Leu Leu 
    930                 935                 940                 


Lys His Met Tyr Glu Val Cys Gln Glu Met Gly Leu Met Glu Asp Leu 
945                 950                 955                 960 


Leu Lys Leu Pro Phe Xaa Asp Xaa Glu Gln Glu Cys Leu Val Lys Phe 
                965                 970                 975     


Leu Gln Ser Ser Ala Ser Val Gln Asn His Glu Phe Leu Leu Val His 
            980                 985                 990         


His Leu Gln Arg Ala Asn Tyr Val  Pro Ala Leu Lys Leu  Asn Gln Xaa 
        995                 1000                 1005             


Leu Lys  Ile Asn Val Met Asn  Asp Arg Asp Pro Arg  Leu Arg Glu 
    1010                 1015                 1020             


Arg Ser  Leu Ala Arg Asn Ser  Ile Leu Asp Gln Tyr  Gly Lys Ile 
    1025                 1030                 1035             


Leu Pro  Arg Val His Arg Lys  Leu Ala Ile Glu Arg  Ala Lys Pro 
    1040                 1045                 1050             


Tyr His  Leu Ser Xaa Ser Ser  Val Phe Arg Leu Val  Ser Arg Pro 
    1055                 1060                 1065             


Lys Pro  Leu Ser Ala Val Pro  Lys Gln Val Val Xaa  Gly Xaa Val 
    1070                 1075                 1080             


Leu Xaa  Arg Ser Val Phe Ile  Asn Asn Val Leu Ser  Lys Ile Gly 
    1085                 1090                 1095             


Glu Val  Trp Ala Ser Lys Glu  Pro Ile Asn Ser Xaa  Xaa Pro Phe 
    1100                 1105                 1110             


Asn Ser  Ser Lys Ile Glu Glu  Pro Ser Pro Ile Val  Tyr Ser Leu 
    1115                 1120                 1125             


Pro Ala  Pro Glu Leu Pro Glu  Ala Phe Phe Gly Xaa  Pro Ile Ser 
    1130                 1135                 1140             


Lys Ala  Ser Gln Lys Ile Ser  Arg Leu Leu Asp Leu  Val Val Gln 
    1145                 1150                 1155             


Pro Val  Pro Arg Pro Ser Gln  Cys Ser Glu Phe Ile  Gln Gln Ser 
    1160                 1165                 1170             


Ser Met  Lys Ser Pro Leu Tyr  Leu Val Ser Arg Ser  Leu Pro Ser 
    1175                 1180                 1185             


Ser Ser  Gln Leu Lys Gly Ser  Pro Gln Ala Ile Ser  Arg Ala Ser 
    1190                 1195                 1200             


Glu Leu  His Leu Leu Glu Xaa  Pro Leu Val Val Lys  Lys Ala Lys 
    1205                 1210                 1215             


Ser Leu  Ala Met Ser Val Xaa  Xaa Ser Gly Phe Ser  Glu Phe Xaa 
    1220                 1225                 1230             


Pro Gln  Ser Ile Leu Arg Ser  Xaa Leu Arg Ser Xaa  Pro Leu Ala 
    1235                 1240                 1245             


Ser Pro  Ser Pro Ser Pro Gly  Arg Ser Pro Gln Arg  Leu Lys Glu 
    1250                 1255                 1260             


Xaa Arg  Ile Ser Phe Val Glu  Glu Asp Val His Pro  Lys Trp Ile 
    1265                 1270                 1275             


Pro Gly  Ala Ala Asp Asp Ser  Lys Leu Glu Val Phe  Xaa Xaa Pro 
    1280                 1285                 1290             


Lys Lys  Cys Ala Val Pro Val  Glu Xaa Glu Trp Leu  Lys Ser Lys 
    1295                 1300                 1305             


Asp Arg  Xaa Xaa Ser Phe Phe  Leu Asn Ser Pro Glu  Lys Glu His 
    1310                 1315                 1320             


Gln Glu  Met Asp Glu Gly Ser  Gln Ser Leu Glu Lys  Leu Asp Val 
    1325                 1330                 1335             


Ser Lys  Gly Asn Ser Ser Val  Ser Ile Xaa Ser Asp  Glu Xaa Xaa 
    1340                 1345                 1350             


Leu Glu  Tyr Gln Asp Ala Pro  Ser Pro Glu Asp Leu  Glu Glu Xaa 
    1355                 1360                 1365             


Val Phe  Xaa Ala Ser Lys Pro  Lys Ser Ser Ser Xaa  Ala Leu Xaa 
    1370                 1375                 1380             


Xaa Asn  Val Xaa Glu Gln Xaa  Glu Lys Asp Gly Asp  Lys Asp Val 
    1385                 1390                 1395             


Phe Ala  Ser Glu Val Xaa Pro  Ser Asp Leu Gln Lys  Gln Met Gly 
    1400                 1405                 1410             


Asn Leu  Glu Asp Ala Glu Xaa  Lys Asp Leu Leu Val  Ala Ala Glu 
    1415                 1420                 1425             


Ala Phe  Ser Glu Leu Asn His  Leu Ser Pro Val Gln  Gly Xaa Glu 
    1430                 1435                 1440             


Ala Ser  Leu Cys Ala Pro Ser  Val Tyr Glu Gly Lys  Ile Phe Xaa 
    1445                 1450                 1455             


Gln Lys  Ser Lys Val Pro Val  Leu Asp Glu Gly Leu  Xaa Ser Val 
    1460                 1465                 1470             


Glu Xaa  Tyr Xaa Pro Ala Ile  Arg Ala Asn Asp Asn  Lys Ser Met 
    1475                 1480                 1485             


Ala Asp  Val Leu Gly Asp Gly  Gly Asn Ser Ser Leu  Xaa Ile Ser 
    1490                 1495                 1500             


Glu Gly  Pro Ile Val Ser Glu  Arg Arg Leu Asn Gln  Glu Val Ala 
    1505                 1510                 1515             


Leu Asn  Leu Lys Glu Asp His  Glu Val Glu Val Gly  Val Leu Lys 
    1520                 1525                 1530             


Glu Ser  Val Asp Leu Pro Glu  Glu Lys Leu Pro Ile  Ser Asp Ser 
    1535                 1540                 1545             


Pro Pro  Asp Xaa Gln Glu Ile  His Val Ile Glu Gln  Glu Lys Leu 
    1550                 1555                 1560             


Glu Ala  Gln Asp Ser Gly Glu  Glu Ala Arg Asn Leu  Ser Phe Asn 
    1565                 1570                 1575             


Glu Leu  Tyr Pro Ser Gly Xaa  Leu Lys Leu Gln Tyr  Asn Phe Asp 
    1580                 1585                 1590             


Xaa Ile  Asp Gln Gln Phe Cys  Asp Leu Ala Asp Asn  Lys Asp Xaa 
    1595                 1600                 1605             


Ala Glu  Cys Asp Ile Ala Glu  Val Asp Gly Glu Leu  Phe Val Ala 
    1610                 1615                 1620             


Gln Ser  Asn Phe Xaa Leu Ile  Leu Glu Gly Glu Glu  Gly Glu Val 
    1625                 1630                 1635             


Glu Pro  Gly Asp Phe Ala Ser  Ser Asp Val Leu Pro  Lys Ala Ala 
    1640                 1645                 1650             


Asn Xaa  Ala Xaa Glu Glu Lys  Leu Val Cys Ser Gly  Glu Asn Asp 
    1655                 1660                 1665             


Asn His  Gly Gln Ile Ala Asn  Leu Pro Ser Ala Val  Xaa Ser Asp 
    1670                 1675                 1680             


Gln Lys  Ser Gln Lys Val Asp  Xaa Leu Pro Tyr Val  Pro Glu Pro 
    1685                 1690                 1695             


Ile Lys  Val Ala Ile Ala Glu  Asn Leu Leu Asp Val  Ile Lys Asp 
    1700                 1705                 1710             


Xaa Arg  Ser Lys Glu Ile Xaa  Ser Asp Xaa Met Glu  Gln Ser Ile 
    1715                 1720                 1725             


His Glu  Xaa Ile Pro Leu Val  Ser Gln Asn Ile Met  Cys Pro Xaa 
    1730                 1735                 1740             


Lys Leu  Val Lys Ser Ala Phe  Lys Xaa Ala Gln Glu  Xaa Ser Xaa 
    1745                 1750                 1755             


Met Xaa  Met Asn Val Ser Gln  Val Asp Asp Val Val  Ser Ser Lys 
    1760                 1765                 1770             


Xaa Arg  Xaa Arg Gly Gln Arg  Ile Gln Asn Val Asn  Val Lys Ser 
    1775                 1780                 1785             


Ala Gln  Gln Glu Ala Ser Ala  Asp Val Ala Xaa Pro  Lys Met Pro 
    1790                 1795                 1800             


Gly Gln  Ser Val Arg Lys Lys  Xaa Arg Lys Ala Lys  Glu Ile Ser 
    1805                 1810                 1815             


Glu Ala  Ser Glu Asn Ile Tyr  Ser Asp Val Arg Gly  Leu Ser Gln 
    1820                 1825                 1830             


Asn Gln  Gln Ile Pro Gln Asn  Ser Val Xaa Pro Arg  Arg Gly Arg 
    1835                 1840                 1845             


Arg Lys  Lys Glu Val Asn Gln  Asp Ile Leu Glu Asn  Xaa Ser Ser 
    1850                 1855                 1860             


Val Glu  Gln Glu Leu Gln Ile  Xaa Xaa Gly Arg Glu  Ser Lys Arg 
    1865                 1870                 1875             


Leu Lys  Ser Ser Gln Leu Leu  Glu Pro Ala Val Glu  Glu Xaa Xaa 
    1880                 1885                 1890             


Lys Lys  Glu Val Lys Val Ser  Ser Val Xaa Lys Arg  Xaa Pro Arg 
    1895                 1900                 1905             


Arg Ile  Lys Arg Ser Val Glu  Asn Gln Glu Ser Val  Glu Ile Ile 
    1910                 1915                 1920             


Asn Asp  Leu Lys Val Ser Xaa  Val Xaa Ser Pro Ser  Arg Met Ile 
    1925                 1930                 1935             


Arg Lys  Leu Arg Ser Xaa Asn  Leu Asp Ala Ser Glu  Asn Xaa Gly 
    1940                 1945                 1950             


Asn Lys  Gln Asp Asp Lys Ser  Ser Asp Lys Gln Leu  Arg Ile Lys 
    1955                 1960                 1965             


His Val  Arg Arg Val Arg Gly  Arg Glu Val Ser Pro  Ser Asp Val 
    1970                 1975                 1980             


Arg Glu  Asp Ser Asn Leu Glu  Ser Ser Gln Leu Xaa  Val Gln Ala 
    1985                 1990                 1995             


Glu Phe  Asp Met Ser Ala Ile  Pro Arg Lys Arg Gly  Arg Pro Arg 
    2000                 2005                 2010             


Lys Ile  Asn Pro Ser Glu Asp  Val Gly Ser Lys Ala  Val Lys Glu 
    2015                 2020                 2025             


Glu Arg  Ser Pro Lys Lys Lys  Glu Ala Pro Ser Ile  Arg Arg Arg 
    2030                 2035                 2040             


Ser Xaa  Arg Asn Xaa Pro Ala  Lys Ser Glu Asn Val  Asp Val Gly 
    2045                 2050                 2055             


Lys Pro  Ala Leu Gly Lys Ser  Ile Leu Val Pro Asn  Glu Glu Leu 
    2060                 2065                 2070             


Ser Met  Val Met Ser Ser Lys  Lys Lys Leu Xaa Lys  Lys Xaa Glu 
    2075                 2080                 2085             


Ser Gln  Ser Gln Lys Arg Ser  Leu His Ser Val Ser  Glu Glu Arg 
    2090                 2095                 2100             


Xaa Asp  Glu Met Xaa His Lys  Glu Xaa Asn Glu Gln  Glu Glu Arg 
    2105                 2110                 2115             


Leu Leu  Ala Xaa Ala Ser Phe  Xaa Lys Ser Ser Arg  Ser Ser Arg 
    2120                 2125                 2130             


Xaa Arg  Ser Ser Lys Ala Ile  Leu Leu Pro Asp Leu  Ser Glu Pro 
    2135                 2140                 2145             


Asn Asn  Glu Pro Leu Phe Ser  Pro Ala Ser Glu Val  Pro Arg Lys 
    2150                 2155                 2160             


Ala Lys  Ala Lys Lys Ile Glu  Val Pro Ala Gln Leu  Lys Glu Leu 
    2165                 2170                 2175             


Val Ser  Asp Leu Ser Ser Gln  Phe Val Ile Ser Pro  Pro Ala Leu 
    2180                 2185                 2190             


Arg Ser  Arg Gln Lys Asn Xaa  Ser Asn Lys Asn Lys  Leu Glu Asp 
    2195                 2200                 2205             


Glu Leu  Lys Asp Asp Ala Gln  Ser Val Glu Xaa Leu  Gly Lys Pro 
    2210                 2215                 2220             


Lys Ala  Lys Arg Ile Arg Xaa  Ser Lys Xaa Lys Gln  Ala Ser Lys 
    2225                 2230                 2235             


Asn Xaa  Glu Lys Glu Ser Ala  Trp Ser Pro Pro Pro  Ile Glu Ile 
    2240                 2245                 2250             


Arg Leu  Ile Ser Pro Leu Ala  Ser Pro Ala Asp Gly  Val Lys Ser 
    2255                 2260                 2265             


Lys Pro  Arg Lys Xaa Xaa Glu  Val Xaa Gly Xaa Gly  Leu Gly Arg 
    2270                 2275                 2280             


Asn Arg  Lys Lys Leu Ser Ser  Tyr Pro Lys Gln Ile  Leu Arg Arg 
    2285                 2290                 2295             


Lys Met  Leu 
    2300     


<210> 2008
<211> 67
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<400> 2008
Met Arg Asp Leu Arg Ala Gln Val Xaa Ser Gly Leu Leu Pro Phe Pro 
1               5                   10                  15      


Glu Val Xaa Leu Gln Ala Leu Gly Glu Asp Glu Ile Xaa Leu Glu Ser 
            20                  25                  30          


Val Leu Arg Gly Lys Phe Ala Ala Gly Lys Asn Gly Leu Ala Cys Leu 
        35                  40                  45              


Ala Cys Gly Pro Gln Leu Glu Val Val Asn Ser Ile Xaa Gly Glu Arg 
    50                  55                  60                  


Leu Ser Ala 
65          


<210> 2009
<211> 483
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<400> 2009
Met Gln Glu Phe Xaa Lys Phe Pro Xaa Lys Xaa Gly Arg Arg Ser Leu 
1               5                   10                  15      


Ser Arg Ser Ile Ser Gln Ser Ser Xaa Asp Ser Tyr Ser Ser Ala Ala 
            20                  25                  30          


Ser Tyr Xaa Asp Ser Ser Asp Asp Glu Val Ser Pro Arg Glu Lys Gln 
        35                  40                  45              


Gln Xaa Asn Ser Lys Gly Ser Ser Asn Phe Cys Val Lys Asn Ile Lys 
    50                  55                  60                  


Gln Ala Glu Phe Gly Arg Arg Glu Ile Glu Ile Ala Glu Gln Asp Met 
65                  70                  75                  80  


Ser Ala Leu Ile Ser Leu Arg Lys Arg Ala Gln Gly Glu Lys Pro Leu 
                85                  90                  95      


Ala Gly Ala Lys Ile Val Gly Cys Xaa His Ile Xaa Ala Gln Xaa Ala 
            100                 105                 110         


Val Leu Ile Glu Xaa Leu Cys Ala Leu Gly Ala Gln Cys Arg Trp Ser 
        115                 120                 125             


Ala Cys Asn Ile Tyr Ser Xaa Gln Asn Glu Val Ala Ala Ala Leu Ala 
    130                 135                 140                 


Glu Ala Gly Val Ala Val Phe Ala Trp Lys Gly Glu Ser Glu Asp Asp 
145                 150                 155                 160 


Phe Trp Trp Cys Ile Asp Arg Cys Val Asn Met Asp Gly Trp Gln Ala 
                165                 170                 175     


Asn Met Ile Leu Asp Asp Gly Gly Asp Leu Xaa His Trp Val Tyr Lys 
            180                 185                 190         


Lys Tyr Pro Asn Val Phe Lys Lys Ile Arg Gly Ile Val Glu Glu Ser 
        195                 200                 205             


Val Xaa Gly Val His Arg Leu Tyr Gln Leu Ser Lys Ala Gly Lys Leu 
    210                 215                 220                 


Cys Val Pro Ala Met Asn Val Asn Asp Ser Val Xaa Lys Gln Lys Phe 
225                 230                 235                 240 


Asp Asn Leu Tyr Cys Cys Arg Glu Ser Ile Leu Asp Gly Leu Lys Arg 
                245                 250                 255     


Xaa Xaa Asp Val Met Phe Gly Gly Lys Gln Val Val Val Cys Gly Tyr 
            260                 265                 270         


Gly Glu Val Gly Lys Gly Cys Cys Ala Ala Leu Lys Ala Leu Gly Ala 
        275                 280                 285             


Ile Val Tyr Ile Xaa Glu Ile Asp Pro Ile Cys Ala Leu Gln Ala Cys 
    290                 295                 300                 


Met Asp Gly Phe Arg Val Val Lys Leu Asn Glu Val Ile Arg Gln Val 
305                 310                 315                 320 


Asp Val Val Ile Xaa Cys Xaa Gly Asn Lys Asn Val Val Xaa Arg Glu 
                325                 330                 335     


His Leu Asp Arg Met Lys Asn Ser Cys Ile Val Cys Asn Met Gly His 
            340                 345                 350         


Ser Asn Xaa Glu Ile Asp Val Xaa Ser Leu Arg Xaa Pro Glu Leu Xaa 
        355                 360                 365             


Trp Glu Arg Val Arg Ser Gln Val Asp His Val Ile Trp Pro Asp Gly 
    370                 375                 380                 


Lys Arg Val Val Leu Leu Ala Glu Gly Arg Leu Leu Asn Leu Ser Cys 
385                 390                 395                 400 


Ser Xaa Val Pro Xaa Phe Val Leu Ser Ile Xaa Ala Xaa Xaa Gln Ala 
                405                 410                 415     


Leu Ala Leu Ile Glu Leu Tyr Asn Ala Pro Glu Gly Arg Tyr Lys Gln 
            420                 425                 430         


Asp Val Tyr Leu Leu Pro Lys Lys Met Asp Glu Tyr Val Ala Ser Leu 
        435                 440                 445             


His Leu Pro Ser Phe Asp Ala His Leu Xaa Glu Leu Xaa Asp Asp Gln 
    450                 455                 460                 


Ala Lys Tyr Leu Gly Leu Asn Lys Asn Gly Pro Phe Lys Pro Asn Tyr 
465                 470                 475                 480 


Tyr Arg Tyr 
            


<210> 2010
<211> 530
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<400> 2010
Met Ser Met Pro Asp Ala Met Pro Leu Pro Gly Val Gly Glu Glu Leu 
1               5                   10                  15      


Lys Gln Ala Lys Glu Ile Glu Asp Ala Glu Lys Tyr Ser Phe Met Ala 
            20                  25                  30          


Xaa Val Xaa Lys Ala Pro Lys Lys Gln Ile Gln Phe Ala Asp Asp Met 
        35                  40                  45              


Gln Glu Phe Xaa Lys Phe Pro Xaa Lys Xaa Gly Arg Arg Ser Leu Ser 
    50                  55                  60                  


Arg Ser Ile Ser Gln Ser Ser Xaa Asp Ser Tyr Ser Ser Ala Ala Ser 
65                  70                  75                  80  


Tyr Xaa Asp Ser Ser Asp Asp Glu Val Ser Pro Arg Glu Lys Gln Gln 
                85                  90                  95      


Xaa Asn Ser Lys Gly Ser Ser Asn Phe Cys Val Lys Asn Ile Lys Gln 
            100                 105                 110         


Ala Glu Phe Gly Arg Arg Glu Ile Glu Ile Ala Glu Gln Asp Met Ser 
        115                 120                 125             


Ala Leu Ile Ser Leu Arg Lys Arg Ala Gln Gly Glu Lys Pro Leu Ala 
    130                 135                 140                 


Gly Ala Lys Ile Val Gly Cys Xaa His Ile Xaa Ala Gln Xaa Ala Val 
145                 150                 155                 160 


Leu Ile Glu Xaa Leu Cys Ala Leu Gly Ala Gln Cys Arg Trp Ser Ala 
                165                 170                 175     


Cys Asn Ile Tyr Ser Xaa Gln Asn Glu Val Ala Ala Ala Leu Ala Glu 
            180                 185                 190         


Ala Gly Val Ala Val Phe Ala Trp Lys Gly Glu Ser Glu Asp Asp Phe 
        195                 200                 205             


Trp Trp Cys Ile Asp Arg Cys Val Asn Met Asp Gly Trp Gln Ala Asn 
    210                 215                 220                 


Met Ile Leu Asp Asp Gly Gly Asp Leu Xaa His Trp Val Tyr Lys Lys 
225                 230                 235                 240 


Tyr Pro Asn Val Phe Lys Lys Ile Arg Gly Ile Val Glu Glu Ser Val 
                245                 250                 255     


Xaa Gly Val His Arg Leu Tyr Gln Leu Ser Lys Ala Gly Lys Leu Cys 
            260                 265                 270         


Val Pro Ala Met Asn Val Asn Asp Ser Val Xaa Lys Gln Lys Phe Asp 
        275                 280                 285             


Asn Leu Tyr Cys Cys Arg Glu Ser Ile Leu Asp Gly Leu Lys Arg Xaa 
    290                 295                 300                 


Xaa Asp Val Met Phe Gly Gly Lys Gln Val Val Val Cys Gly Tyr Gly 
305                 310                 315                 320 


Glu Val Gly Lys Gly Cys Cys Ala Ala Leu Lys Ala Leu Gly Ala Ile 
                325                 330                 335     


Val Tyr Ile Xaa Glu Ile Asp Pro Ile Cys Ala Leu Gln Ala Cys Met 
            340                 345                 350         


Asp Gly Phe Arg Val Val Lys Leu Asn Glu Val Ile Arg Gln Val Asp 
        355                 360                 365             


Val Val Ile Xaa Cys Xaa Gly Asn Lys Asn Val Val Xaa Arg Glu His 
    370                 375                 380                 


Leu Asp Arg Met Lys Asn Ser Cys Ile Val Cys Asn Met Gly His Ser 
385                 390                 395                 400 


Asn Xaa Glu Ile Asp Val Xaa Ser Leu Arg Xaa Pro Glu Leu Xaa Trp 
                405                 410                 415     


Glu Arg Val Arg Ser Gln Val Asp His Val Ile Trp Pro Asp Gly Lys 
            420                 425                 430         


Arg Val Val Leu Leu Ala Glu Gly Arg Leu Leu Asn Leu Ser Cys Ser 
        435                 440                 445             


Xaa Val Pro Xaa Phe Val Leu Ser Ile Xaa Ala Xaa Xaa Gln Ala Leu 
    450                 455                 460                 


Ala Leu Ile Glu Leu Tyr Asn Ala Pro Glu Gly Arg Tyr Lys Gln Asp 
465                 470                 475                 480 


Val Tyr Leu Leu Pro Lys Lys Met Asp Glu Tyr Val Ala Ser Leu His 
                485                 490                 495     


Leu Pro Ser Phe Asp Ala His Leu Xaa Glu Leu Xaa Asp Asp Gln Ala 
            500                 505                 510         


Lys Tyr Leu Gly Leu Asn Lys Asn Gly Pro Phe Lys Pro Asn Tyr Tyr 
        515                 520                 525             


Arg Tyr 
    530 


<210> 2011
<211> 54
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<400> 2011
Met Pro Xaa Ala Glu Ser Glu Ala Lys Val Lys Xaa Lys Val Arg Phe 
1               5                   10                  15      


Glu Glu Leu Leu Lys Xaa His Ser Asp Leu Met Arg Glu Lys Lys Lys 
            20                  25                  30          


Leu Lys Lys Lys Leu Val Arg Ser Glu Glu Asn Ile Ser Asn Gln Glu 
        35                  40                  45              


Lys Ser Met Ala Val Trp 
    50                  


<210> 2012
<211> 609
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<400> 2012
Met Pro Xaa Ala Glu Ser Glu Ala Lys Val Lys Xaa Lys Val Arg Phe 
1               5                   10                  15      


Glu Glu Leu Leu Lys Xaa His Ser Asp Leu Met Arg Glu Lys Lys Lys 
            20                  25                  30          


Leu Lys Lys Lys Leu Val Arg Ser Glu Glu Asn Ile Ser Pro Asp Xaa 
        35                  40                  45              


Ile Arg Ser Asn Leu His Tyr Met Lys Glu Xaa Xaa Ser Asp Asp Pro 
    50                  55                  60                  


Asp Xaa Ile Arg Ser Asn Leu Pro His Ile Lys Glu Xaa Xaa Ser Asp 
65                  70                  75                  80  


Asp Val Ser Ala Ala Asn Xaa Asn Asn Leu Lys Lys Ser Xaa Arg Val 
                85                  90                  95      


Xaa Lys Asn Lys Leu Arg Asn Xaa Gln Leu Ala Xaa Glu Asn Pro Asn 
            100                 105                 110         


Gly Asp Ala Ser Val Glu Glu Asp Lys Gln Gly Lys Pro Asn Lys Lys 
        115                 120                 125             


Val Ile Lys Xaa Val Pro Gln Leu Xaa Xaa Gln Asp Leu Lys Pro Glu 
    130                 135                 140                 


Xaa Pro Glu Asn Lys Val Asp Ser Xaa His Gln Lys Xaa His Xaa Lys 
145                 150                 155                 160 


Pro Gln Pro Gly Val Asp His Gln Lys Ser Glu Lys Ala Asn Glu Gly 
                165                 170                 175     


Arg Glu Glu Xaa Asp Leu Glu Glu Asp Glu Glu Leu Met Gln Ala Tyr 
            180                 185                 190         


Gln Cys His Val Xaa Glu Glu Met Ala Lys Glu Ile Lys Arg Lys Ile 
        195                 200                 205             


Arg Lys Lys Leu Lys Glu Gln Leu Xaa Tyr Phe Pro Ser Asp Xaa Leu 
    210                 215                 220                 


Phe His Asp Asp Lys Leu Ser Ser Glu Lys Arg Lys Lys Lys Lys Glu 
225                 230                 235                 240 


Val Pro Val Phe Ser Lys Ala Glu Xaa Ser Xaa Leu Xaa Ile Ser Gly 
                245                 250                 255     


Asp Xaa Val Glu Gly Glu Gln Lys Lys Glu Ser Ser Val Arg Ser Val 
            260                 265                 270         


Ser Ser Asp Ser His Gln Asp Asp Glu Ile Ser Ser Met Glu Gln Ser 
        275                 280                 285             


Xaa Glu Asp Ser Met Gln Asp Asp Xaa Lys Pro Lys Pro Lys Lys Xaa 
    290                 295                 300                 


Lys Lys Lys Xaa Lys Ala Val Ala Asp Asn Asn Glu Asp Val Asp Gly 
305                 310                 315                 320 


Asp Gly Val His Glu Ile Xaa Ser Arg Asp Ser Pro Val Tyr Pro Lys 
                325                 330                 335     


Cys Leu Leu Asp Asp Asp Leu Val Leu Gly Val Tyr Ile His Arg Xaa 
            340                 345                 350         


Asp Arg Leu Lys Ser Asp Phe Met Ile Ser His Pro Met Val Lys Ile 
        355                 360                 365             


His Val Val Asp Glu His Xaa Gly Gln Tyr Val Lys Lys Asp Asp Ser 
    370                 375                 380                 


Gly Arg Pro Val Ser Ser Tyr Tyr Glu Lys Glu Asn Val Asp Tyr Ile 
385                 390                 395                 400 


Leu Pro Ile Met Xaa Gln Pro Tyr Asp Phe Lys Gln Leu Lys Ser Arg 
                405                 410                 415     


Leu Pro Glu Trp Glu Glu Gln Ile Val Phe Asn Glu Asn Phe Pro Tyr 
            420                 425                 430         


Leu Leu Arg Gly Ser Asp Glu Ser Pro Lys Val Ile Leu Phe Phe Glu 
        435                 440                 445             


Ile Leu Asp Phe Leu Ser Val Asp Glu Ile Lys Asn Asn Ser Glu Val 
    450                 455                 460                 


Gln Asn Gln Glu Cys Gly Phe Arg Lys Ile Ala Trp Ala Phe Leu Lys 
465                 470                 475                 480 


Leu Leu Gly Ala Asn Gly Asn Ala Asn Ile Asn Ser Lys Leu Arg Leu 
                485                 490                 495     


Gln Leu Tyr Tyr Pro Pro Xaa Lys Pro Arg Ser Pro Leu Ser Val Val 
            500                 505                 510         


Glu Ala Phe Glu Trp Trp Ser Lys Cys Pro Arg Asn His Tyr Pro Ser 
        515                 520                 525             


Xaa Leu Tyr Val Xaa Val Arg Gly Leu Lys Val Pro Asp Cys Ile Lys 
    530                 535                 540                 


Pro Ser Tyr Arg Ser Met Met Ala Leu Gln Glu Glu Lys Gly Lys Pro 
545                 550                 555                 560 


Val His Cys Glu Arg His His Glu Ser Ser Ser Val Asp Xaa Glu Pro 
                565                 570                 575     


Gly Leu Glu Glu Ser Lys Glu Val Ile Lys Trp Lys Arg Leu Pro Gly 
            580                 585                 590         


Gln Glu Asn Glu Asp Val Phe Val Leu Ile Ser Pro Xaa Met Glu Glu 
        595                 600                 605             


Tyr 
    


<210> 2013
<211> 1053
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<400> 2013
Met Pro Xaa Ala Glu Ser Glu Ala Lys Val Lys Xaa Lys Val Arg Phe 
1               5                   10                  15      


Glu Glu Leu Leu Lys Xaa His Ser Asp Leu Met Arg Glu Lys Lys Lys 
            20                  25                  30          


Leu Lys Lys Lys Leu Val Arg Ser Glu Glu Asn Ile Ser Pro Asp Xaa 
        35                  40                  45              


Ile Arg Ser Asn Leu His Tyr Met Lys Glu Xaa Xaa Ser Asp Asp Pro 
    50                  55                  60                  


Asp Xaa Ile Arg Ser Asn Leu Pro His Ile Lys Glu Xaa Xaa Ser Asp 
65                  70                  75                  80  


Asp Val Ser Ala Ala Asn Xaa Asn Asn Leu Lys Lys Ser Xaa Arg Val 
                85                  90                  95      


Xaa Lys Asn Lys Leu Arg Asn Xaa Gln Leu Ala Xaa Glu Asn Pro Asn 
            100                 105                 110         


Gly Asp Ala Ser Val Glu Glu Asp Lys Gln Gly Lys Pro Asn Lys Lys 
        115                 120                 125             


Val Ile Lys Xaa Val Pro Gln Leu Xaa Xaa Gln Asp Leu Lys Pro Glu 
    130                 135                 140                 


Xaa Pro Glu Asn Lys Val Asp Ser Xaa His Gln Lys Xaa His Xaa Lys 
145                 150                 155                 160 


Pro Gln Pro Gly Val Asp His Gln Lys Ser Glu Lys Ala Asn Glu Gly 
                165                 170                 175     


Arg Glu Glu Xaa Asp Leu Glu Glu Asp Glu Glu Leu Met Gln Ala Tyr 
            180                 185                 190         


Gln Cys His Val Xaa Glu Glu Met Ala Lys Glu Ile Lys Arg Lys Ile 
        195                 200                 205             


Arg Lys Lys Leu Lys Glu Gln Leu Xaa Tyr Phe Pro Ser Asp Xaa Leu 
    210                 215                 220                 


Phe His Asp Asp Lys Leu Ser Ser Glu Lys Arg Lys Lys Lys Lys Glu 
225                 230                 235                 240 


Val Pro Val Phe Ser Lys Ala Glu Xaa Ser Xaa Leu Xaa Ile Ser Gly 
                245                 250                 255     


Asp Xaa Val Glu Gly Glu Gln Lys Lys Glu Ser Ser Val Arg Ser Val 
            260                 265                 270         


Ser Ser Asp Ser His Gln Asp Asp Glu Ile Ser Ser Met Glu Gln Ser 
        275                 280                 285             


Xaa Glu Asp Ser Met Gln Asp Asp Xaa Lys Pro Lys Pro Lys Lys Xaa 
    290                 295                 300                 


Lys Lys Lys Xaa Lys Ala Val Ala Asp Asn Asn Glu Asp Val Asp Gly 
305                 310                 315                 320 


Asp Gly Val His Glu Ile Xaa Ser Arg Asp Ser Pro Val Tyr Pro Lys 
                325                 330                 335     


Cys Leu Leu Asp Asp Asp Leu Val Leu Gly Val Tyr Ile His Arg Xaa 
            340                 345                 350         


Asp Arg Leu Lys Ser Asp Phe Met Ile Ser His Pro Met Val Lys Ile 
        355                 360                 365             


His Val Val Asp Glu His Xaa Gly Gln Tyr Val Lys Lys Asp Asp Ser 
    370                 375                 380                 


Gly Arg Pro Val Ser Ser Tyr Tyr Glu Lys Glu Asn Val Asp Tyr Ile 
385                 390                 395                 400 


Leu Pro Ile Met Xaa Gln Pro Tyr Asp Phe Lys Gln Leu Lys Ser Arg 
                405                 410                 415     


Leu Pro Glu Trp Glu Glu Gln Ile Val Phe Asn Glu Asn Phe Pro Tyr 
            420                 425                 430         


Leu Leu Arg Gly Ser Asp Glu Ser Pro Lys Val Ile Leu Phe Phe Glu 
        435                 440                 445             


Ile Leu Asp Phe Leu Ser Val Asp Glu Ile Lys Asn Asn Ser Glu Val 
    450                 455                 460                 


Gln Asn Gln Glu Cys Gly Phe Arg Lys Ile Ala Trp Ala Phe Leu Lys 
465                 470                 475                 480 


Leu Leu Gly Ala Asn Gly Asn Ala Asn Ile Asn Ser Lys Leu Arg Leu 
                485                 490                 495     


Gln Leu Tyr Tyr Pro Pro Xaa Lys Pro Arg Ser Pro Leu Ser Val Val 
            500                 505                 510         


Glu Ala Phe Glu Trp Trp Ser Lys Cys Pro Arg Asn His Tyr Pro Ser 
        515                 520                 525             


Xaa Leu Tyr Val Xaa Val Arg Gly Leu Lys Val Pro Asp Cys Ile Lys 
    530                 535                 540                 


Pro Ser Tyr Arg Ser Met Met Ala Leu Gln Glu Glu Lys Gly Lys Pro 
545                 550                 555                 560 


Val His Cys Glu Arg His His Glu Ser Ser Ser Val Asp Xaa Glu Pro 
                565                 570                 575     


Gly Leu Glu Glu Ser Lys Glu Val Ile Lys Trp Lys Arg Leu Pro Gly 
            580                 585                 590         


Gln Ala Cys Arg Ile Pro Asn Lys His Leu Phe Ser Leu Asn Ala Gly 
        595                 600                 605             


Glu Arg Gly Cys Phe Cys Leu Asp Phe Ser His Asn Gly Arg Ile Leu 
    610                 615                 620                 


Ala Ala Ala Cys Ala Ser Arg Asp Gly Tyr Pro Ile Ile Leu Tyr Glu 
625                 630                 635                 640 


Ile Pro Ser Gly Arg Phe Met Arg Glu Leu Cys Gly His Leu Asn Ile 
                645                 650                 655     


Ile Tyr Asp Leu Ser Trp Ser Lys Asp Asp His Tyr Ile Leu Xaa Ser 
            660                 665                 670         


Ser Ser Asp Gly Xaa Ala Arg Ile Trp Lys Asn Glu Ile Asn Asn Xaa 
        675                 680                 685             


Asn Xaa Phe Arg Val Leu Pro His Pro Ser Phe Val Tyr Xaa Ala Lys 
    690                 695                 700                 


Phe His Pro Ala Val Arg Glu Leu Val Val Xaa Gly Cys Tyr Asp Ser 
705                 710                 715                 720 


Met Ile Arg Ile Trp Lys Val Glu Met Arg Glu Asp Ser Ala Ile Leu 
                725                 730                 735     


Val Arg Gln Phe Asp Val His Lys Ser Phe Ile Asn Ser Leu Cys Phe 
            740                 745                 750         


Asp Xaa Glu Gly His His Met Tyr Ser Gly Asp Cys Xaa Gly Val Ile 
        755                 760                 765             


Val Val Trp Asn Xaa Tyr Val Lys Ile Asn Asp Leu Glu His Ser Val 
    770                 775                 780                 


His His Trp Xaa Ile Asn Lys Glu Ile Lys Glu Xaa Glu Phe Lys Gly 
785                 790                 795                 800 


Ile Pro Ile Ser Tyr Leu Glu Ile His Pro Asn Gly Lys Arg Leu Leu 
                805                 810                 815     


Ile His Xaa Lys Asp Ser Xaa Leu Arg Ile Met Asp Leu Arg Ile Leu 
            820                 825                 830         


Val Ala Arg Lys Phe Val Gly Ala Ala Asn Tyr Arg Glu Lys Ile His 
        835                 840                 845             


Ser Xaa Leu Xaa Pro Cys Gly Xaa Phe Leu Phe Ala Gly Ser Glu Asp 
    850                 855                 860                 


Gly Ile Val Tyr Val Trp Asn Pro Glu Xaa Gly Glu Gln Val Ala Met 
865                 870                 875                 880 


Tyr Ser Asp Leu Pro Phe Lys Ser Pro Ile Arg Asp Ile Ser Tyr His 
                885                 890                 895     


Pro Phe Glu Asn Met Val Ala Phe Cys Ala Phe Gly Gln Asn Glu Pro 
            900                 905                 910         


Ile Leu Leu Tyr Ile Tyr Asp Phe His Val Ala Gln Gln Glu Ala Glu 
        915                 920                 925             


Met Phe Lys Arg Tyr Asn Gly Xaa Phe Pro Leu Pro Gly Ile His Gln 
    930                 935                 940                 


Ser Gln Asp Ala Leu Cys Xaa Cys Pro Lys Leu Pro His Gln Gly Ser 
945                 950                 955                 960 


Phe Gln Ile Asp Glu Phe Val His Xaa Glu Ser Ser Ser Xaa Lys Met 
                965                 970                 975     


Gln Leu Val Lys Gln Arg Leu Glu Xaa Val Xaa Glu Val Ile Arg Ser 
            980                 985                 990         


Cys Ala Ala Lys Val Asn Lys Asn  Leu Ser Phe Xaa Ser  Pro Pro Ala 
        995                 1000                 1005             


Val Ser  Ser Gln Gln Ser Lys  Leu Lys Gln Ser Asn  Met Leu Xaa 
    1010                 1015                 1020             


Ala Gln  Glu Ile Leu His Gln  Phe Gly Phe Xaa Gln  Xaa Asp Ser 
    1025                 1030                 1035             


His Phe  Ala Glu Phe Asn Xaa  Cys Ile Leu Trp Trp  Lys Lys His 
    1040                 1045                 1050             


<210> 2014
<211> 1196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1071)..(1071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1161)..(1161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1193)..(1193)
<223> Selenocysteine

<400> 2014
Met Pro Xaa Ala Glu Ser Glu Ala Lys Val Lys Xaa Lys Val Arg Phe 
1               5                   10                  15      


Glu Glu Leu Leu Lys Xaa His Ser Asp Leu Met Arg Glu Lys Lys Lys 
            20                  25                  30          


Leu Lys Lys Lys Leu Val Arg Ser Glu Glu Asn Ile Ser Pro Asp Xaa 
        35                  40                  45              


Ile Arg Ser Asn Leu His Tyr Met Lys Glu Xaa Xaa Ser Asp Asp Pro 
    50                  55                  60                  


Asp Xaa Ile Arg Ser Asn Leu Pro His Ile Lys Glu Xaa Xaa Ser Asp 
65                  70                  75                  80  


Asp Val Ser Ala Ala Asn Xaa Asn Asn Leu Lys Lys Ser Xaa Arg Val 
                85                  90                  95      


Xaa Lys Asn Lys Leu Arg Asn Xaa Gln Leu Ala Xaa Glu Asn Pro Asn 
            100                 105                 110         


Gly Asp Ala Ser Val Glu Glu Asp Lys Gln Gly Lys Pro Asn Lys Lys 
        115                 120                 125             


Val Ile Lys Xaa Val Pro Gln Leu Xaa Xaa Gln Asp Leu Lys Pro Glu 
    130                 135                 140                 


Xaa Pro Glu Asn Lys Val Asp Ser Xaa His Gln Lys Xaa His Xaa Lys 
145                 150                 155                 160 


Pro Gln Pro Gly Val Asp His Gln Lys Ser Glu Lys Ala Asn Glu Gly 
                165                 170                 175     


Arg Glu Glu Xaa Asp Leu Glu Glu Asp Glu Glu Leu Met Gln Ala Tyr 
            180                 185                 190         


Gln Cys His Val Xaa Glu Glu Met Ala Lys Glu Ile Lys Arg Lys Ile 
        195                 200                 205             


Arg Lys Lys Leu Lys Glu Gln Leu Xaa Tyr Phe Pro Ser Asp Xaa Leu 
    210                 215                 220                 


Phe His Asp Asp Lys Leu Ser Ser Glu Lys Arg Lys Lys Lys Lys Glu 
225                 230                 235                 240 


Val Pro Val Phe Ser Lys Ala Glu Xaa Ser Xaa Leu Xaa Ile Ser Gly 
                245                 250                 255     


Asp Xaa Val Glu Gly Glu Gln Lys Lys Glu Ser Ser Val Arg Ser Val 
            260                 265                 270         


Ser Ser Asp Ser His Gln Asp Asp Glu Ile Ser Ser Met Glu Gln Ser 
        275                 280                 285             


Xaa Glu Asp Ser Met Gln Asp Asp Xaa Lys Pro Lys Pro Lys Lys Xaa 
    290                 295                 300                 


Lys Lys Lys Xaa Lys Ala Val Ala Asp Asn Asn Glu Asp Val Asp Gly 
305                 310                 315                 320 


Asp Gly Val His Glu Ile Xaa Ser Arg Asp Ser Pro Val Tyr Pro Lys 
                325                 330                 335     


Cys Leu Leu Asp Asp Asp Leu Val Leu Gly Val Tyr Ile His Arg Xaa 
            340                 345                 350         


Asp Arg Leu Lys Ser Asp Phe Met Ile Ser His Pro Met Val Lys Ile 
        355                 360                 365             


His Val Val Asp Glu His Xaa Gly Gln Tyr Val Lys Lys Asp Asp Ser 
    370                 375                 380                 


Gly Arg Pro Val Ser Ser Tyr Tyr Glu Lys Glu Asn Val Asp Tyr Ile 
385                 390                 395                 400 


Leu Pro Ile Met Xaa Gln Pro Tyr Asp Phe Lys Gln Leu Lys Ser Arg 
                405                 410                 415     


Leu Pro Glu Trp Glu Glu Gln Ile Val Phe Asn Glu Asn Phe Pro Tyr 
            420                 425                 430         


Leu Leu Arg Gly Ser Asp Glu Ser Pro Lys Val Ile Leu Phe Phe Glu 
        435                 440                 445             


Ile Leu Asp Phe Leu Ser Val Asp Glu Ile Lys Asn Asn Ser Glu Val 
    450                 455                 460                 


Gln Asn Gln Glu Cys Gly Phe Arg Lys Ile Ala Trp Ala Phe Leu Lys 
465                 470                 475                 480 


Leu Leu Gly Ala Asn Gly Asn Ala Asn Ile Asn Ser Lys Leu Arg Leu 
                485                 490                 495     


Gln Leu Tyr Tyr Pro Pro Xaa Lys Pro Arg Ser Pro Leu Ser Val Val 
            500                 505                 510         


Glu Ala Phe Glu Trp Trp Ser Lys Cys Pro Arg Asn His Tyr Pro Ser 
        515                 520                 525             


Xaa Leu Tyr Val Xaa Val Arg Gly Leu Lys Val Pro Asp Cys Ile Lys 
    530                 535                 540                 


Pro Ser Tyr Arg Ser Met Met Ala Leu Gln Glu Glu Lys Gly Lys Pro 
545                 550                 555                 560 


Val His Cys Glu Arg His His Glu Ser Ser Ser Val Asp Xaa Glu Pro 
                565                 570                 575     


Gly Leu Glu Glu Ser Lys Glu Val Ile Lys Trp Lys Arg Leu Pro Gly 
            580                 585                 590         


Gln Ala Cys Arg Ile Pro Asn Lys His Leu Phe Ser Leu Asn Ala Gly 
        595                 600                 605             


Glu Arg Gly Cys Phe Cys Leu Asp Phe Ser His Asn Gly Arg Ile Leu 
    610                 615                 620                 


Ala Ala Ala Cys Ala Ser Arg Asp Gly Tyr Pro Ile Ile Leu Tyr Glu 
625                 630                 635                 640 


Ile Pro Ser Gly Arg Phe Met Arg Glu Leu Cys Gly His Leu Asn Ile 
                645                 650                 655     


Ile Tyr Asp Leu Ser Trp Ser Lys Asp Asp His Tyr Ile Leu Xaa Ser 
            660                 665                 670         


Ser Ser Asp Gly Xaa Ala Arg Ile Trp Lys Asn Glu Ile Asn Asn Xaa 
        675                 680                 685             


Asn Xaa Phe Arg Val Leu Pro His Pro Ser Phe Val Tyr Xaa Ala Lys 
    690                 695                 700                 


Phe His Pro Ala Val Arg Glu Leu Val Val Xaa Gly Cys Tyr Asp Ser 
705                 710                 715                 720 


Met Ile Arg Ile Trp Lys Val Glu Met Arg Glu Asp Ser Ala Ile Leu 
                725                 730                 735     


Val Arg Gln Phe Asp Val His Lys Ser Phe Ile Asn Ser Leu Cys Phe 
            740                 745                 750         


Asp Xaa Glu Gly His His Met Tyr Ser Gly Asp Cys Xaa Gly Val Ile 
        755                 760                 765             


Val Val Trp Asn Xaa Tyr Val Lys Ile Asn Asp Leu Glu His Ser Val 
    770                 775                 780                 


His His Trp Xaa Ile Asn Lys Glu Ile Lys Glu Xaa Glu Phe Lys Gly 
785                 790                 795                 800 


Ile Pro Ile Ser Tyr Leu Glu Ile His Pro Asn Gly Lys Arg Leu Leu 
                805                 810                 815     


Ile His Xaa Lys Asp Ser Xaa Leu Arg Ile Met Asp Leu Arg Ile Leu 
            820                 825                 830         


Val Ala Arg Lys Phe Val Gly Ala Ala Asn Tyr Arg Glu Lys Ile His 
        835                 840                 845             


Ser Xaa Leu Xaa Pro Cys Gly Xaa Phe Leu Phe Ala Gly Ser Glu Asp 
    850                 855                 860                 


Gly Ile Val Tyr Val Trp Asn Pro Glu Xaa Gly Glu Gln Val Ala Met 
865                 870                 875                 880 


Tyr Ser Asp Leu Pro Phe Lys Ser Pro Ile Arg Asp Ile Ser Tyr His 
                885                 890                 895     


Pro Phe Glu Asn Met Val Ala Phe Cys Ala Phe Gly Gln Asn Glu Pro 
            900                 905                 910         


Ile Leu Leu Tyr Ile Tyr Asp Phe His Val Ala Gln Gln Glu Ala Glu 
        915                 920                 925             


Met Phe Lys Arg Tyr Asn Gly Xaa Phe Pro Leu Pro Gly Ile His Gln 
    930                 935                 940                 


Ser Gln Asp Ala Leu Cys Xaa Cys Pro Lys Leu Pro His Gln Gly Ser 
945                 950                 955                 960 


Phe Gln Ile Asp Glu Phe Val His Xaa Glu Ser Ser Ser Xaa Lys Met 
                965                 970                 975     


Gln Leu Val Lys Gln Arg Leu Glu Xaa Val Xaa Glu Val Ile Arg Ser 
            980                 985                 990         


Cys Ala Ala Lys Val Asn Lys Asn  Leu Ser Phe Xaa Ser  Pro Pro Ala 
        995                 1000                 1005             


Val Ser  Ser Gln Gln Ser Lys  Leu Lys Gln Ser Asn  Met Leu Xaa 
    1010                 1015                 1020             


Ala Gln  Glu Ile Leu His Gln  Phe Gly Phe Xaa Gln  Xaa Gly Ile 
    1025                 1030                 1035             


Ile Ser  Ile Glu Arg Lys Pro  Cys Asn His Gln Val  Asp Xaa Ala 
    1040                 1045                 1050             


Pro Xaa  Val Val Ala Leu Tyr  Asp Tyr Xaa Ala Asn  Arg Ser Asp 
    1055                 1060                 1065             


Glu Leu  Xaa Ile His Arg Gly  Asp Ile Ile Arg Val  Phe Phe Lys 
    1070                 1075                 1080             


Asp Asn  Glu Asp Trp Trp Tyr  Gly Ser Ile Gly Lys  Gly Gln Glu 
    1085                 1090                 1095             


Gly Tyr  Phe Pro Ala Asn His  Val Ala Ser Glu Xaa  Leu Tyr Gln 
    1100                 1105                 1110             


Glu Leu  Pro Pro Glu Ile Lys  Glu Arg Ser Pro Pro  Leu Ser Pro 
    1115                 1120                 1125             


Glu Glu  Lys Xaa Lys Ile Glu  Lys Ser Pro Ala Pro  Gln Lys Gln 
    1130                 1135                 1140             


Ser Ile  Asn Lys Asn Lys Ser  Gln Asp Phe Arg Leu  Gly Ser Glu 
    1145                 1150                 1155             


Ser Met  Xaa His Ser Glu Met  Arg Lys Glu Gln Ser  His Glu Asp 
    1160                 1165                 1170             


Gln Gly  His Ile Met Asp Xaa  Arg Met Arg Lys Asn  Lys Gln Ala 
    1175                 1180                 1185             


Gly Arg  Lys Val Xaa Leu Ile  Glu 
    1190                 1195     


<210> 2015
<211> 288
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<400> 2015
Met Pro Xaa Ala Glu Ser Glu Ala Lys Val Lys Xaa Lys Val Arg Phe 
1               5                   10                  15      


Glu Glu Leu Leu Lys Xaa His Ser Asp Leu Met Arg Glu Lys Lys Lys 
            20                  25                  30          


Leu Lys Lys Lys Leu Val Arg Ser Glu Glu Asn Ile Ser Pro Asp Xaa 
        35                  40                  45              


Ile Arg Ser Asn Leu Pro His Ile Lys Glu Xaa Xaa Ser Asp Asp Val 
    50                  55                  60                  


Ser Ala Ala Asn Xaa Asn Asn Leu Lys Lys Ser Xaa Arg Val Xaa Lys 
65                  70                  75                  80  


Asn Lys Leu Arg Asn Xaa Gln Leu Ala Xaa Glu Asn Pro Asn Gly Asp 
                85                  90                  95      


Ala Ser Val Glu Glu Asp Lys Gln Gly Lys Pro Asn Lys Lys Val Ile 
            100                 105                 110         


Lys Xaa Val Pro Gln Leu Xaa Xaa Gln Asp Leu Lys Pro Glu Xaa Pro 
        115                 120                 125             


Glu Asn Lys Val Asp Ser Xaa His Gln Lys Xaa His Xaa Lys Pro Gln 
    130                 135                 140                 


Pro Gly Val Asp His Gln Lys Ser Glu Lys Ala Asn Glu Gly Arg Glu 
145                 150                 155                 160 


Glu Xaa Asp Leu Glu Glu Asp Glu Glu Leu Met Gln Ala Tyr Gln Cys 
                165                 170                 175     


His Val Xaa Glu Glu Met Ala Lys Glu Ile Lys Arg Lys Ile Arg Lys 
            180                 185                 190         


Lys Leu Lys Glu Gln Leu Xaa Tyr Phe Pro Ser Asp Xaa Leu Phe His 
        195                 200                 205             


Asp Asp Lys Leu Ser Ser Glu Lys Arg Lys Lys Lys Lys Glu Val Pro 
    210                 215                 220                 


Val Phe Ser Lys Ala Glu Xaa Ser Xaa Leu Xaa Ile Ser Gly Asp Xaa 
225                 230                 235                 240 


Val Glu Gly Glu Gln Lys Lys Glu Ser Ser Val Arg Ser Val Ser Ser 
                245                 250                 255     


Asp Ser His Gln Asp Asp Glu Ile Ser Ser Met Glu Gln Ser Xaa Glu 
            260                 265                 270         


Asp Ser Met Gln Asp Asp Xaa Lys Pro Lys Pro Lys Lys Xaa Lys Lys 
        275                 280                 285             


<210> 2016
<211> 48
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<400> 2016
Met Pro Xaa Ala Glu Ser Glu Ala Lys Val Lys Xaa Lys Val Arg Phe 
1               5                   10                  15      


Glu Glu Leu Leu Lys Xaa His Ser Asp Leu Met Arg Glu Lys Lys Lys 
            20                  25                  30          


Leu Lys Lys Lys Leu Val Arg Ser Glu Glu Asn Ile Ser Val Ser Lys 
        35                  40                  45              


<210> 2017
<211> 29
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<400> 2017
Xaa Asp Phe Arg Leu Gly Ser Glu Ser Met Xaa Gln Arg Glu Leu Asn 
1               5                   10                  15      


Glu Lys Ala Gly Gly Ile Cys Ile Ala Arg Glu Gly Leu 
            20                  25                  


<210> 2018
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 2018
Xaa Gly Xaa Phe Pro Leu Pro Gly Ile His Gln Ser Gln Asp Ala Leu 
1               5                   10                  15      


Cys Xaa Cys Pro Lys Leu Pro His Gln Gly Ser Phe Gln Ile Asp Glu 
            20                  25                  30          


Phe Val His Xaa Glu Ser Ser Ser Xaa Lys Met Gln Leu Val Lys Gln 
        35                  40                  45              


Arg Leu Glu Xaa Val Xaa Glu Val Ile Arg Ser Cys Ala Ala Lys Val 
    50                  55                  60                  


Asn Lys Asn Leu Ser Phe Xaa Ser Pro Pro Ala Val Ser Ser Gln Gln 
65                  70                  75                  80  


Ser Lys Leu Lys Gln Ser Asn Met Leu Xaa Ala Gln Glu Ile Leu His 
                85                  90                  95      


Gln Phe Gly Phe Xaa Gln Xaa Gly Glu Pro Leu Ser Tyr Phe Asp Asn 
            100                 105                 110         


Ser Phe Lys Cys Ser Asp Ala Cys Cys Val Asp Glu Tyr His Leu Phe 
        115                 120                 125             


Leu 
    


<210> 2019
<211> 668
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<400> 2019
Xaa Pro Xaa Lys Pro Arg Ser Pro Leu Ser Val Val Glu Ala Phe Glu 
1               5                   10                  15      


Trp Trp Ser Lys Cys Pro Arg Asn His Tyr Pro Ser Xaa Leu Tyr Val 
            20                  25                  30          


Xaa Val Arg Gly Leu Lys Val Pro Asp Cys Ile Lys Pro Ser Tyr Arg 
        35                  40                  45              


Ser Met Met Ala Leu Gln Glu Glu Lys Gly Lys Pro Val His Cys Glu 
    50                  55                  60                  


Arg His His Glu Ser Ser Ser Val Asp Xaa Glu Pro Gly Leu Glu Glu 
65                  70                  75                  80  


Ser Lys Glu Val Ile Lys Trp Lys Arg Leu Pro Gly Gln Ala Cys Arg 
                85                  90                  95      


Ile Pro Asn Lys His Leu Phe Ser Leu Asn Ala Gly Glu Arg Gly Cys 
            100                 105                 110         


Phe Cys Leu Asp Phe Ser His Asn Gly Arg Ile Leu Ala Ala Ala Cys 
        115                 120                 125             


Ala Ser Arg Asp Gly Tyr Pro Ile Ile Leu Tyr Glu Ile Pro Ser Gly 
    130                 135                 140                 


Arg Phe Met Arg Glu Leu Cys Gly His Leu Asn Ile Ile Tyr Asp Leu 
145                 150                 155                 160 


Ser Trp Ser Lys Asp Asp His Tyr Ile Leu Xaa Ser Ser Ser Asp Gly 
                165                 170                 175     


Xaa Ala Arg Ile Trp Lys Asn Glu Ile Asn Asn Xaa Asn Xaa Phe Arg 
            180                 185                 190         


Val Leu Pro His Pro Ser Phe Val Tyr Xaa Ala Lys Phe His Pro Ala 
        195                 200                 205             


Val Arg Glu Leu Val Val Xaa Gly Cys Tyr Asp Ser Met Ile Arg Ile 
    210                 215                 220                 


Trp Lys Val Glu Met Arg Glu Asp Ser Ala Ile Leu Val Arg Gln Phe 
225                 230                 235                 240 


Asp Val His Lys Ser Phe Ile Asn Ser Leu Cys Phe Asp Xaa Glu Gly 
                245                 250                 255     


His His Met Tyr Ser Gly Asp Cys Xaa Gly Val Ile Val Val Trp Asn 
            260                 265                 270         


Xaa Tyr Val Lys Ile Asn Asp Leu Glu His Ser Val His His Trp Xaa 
        275                 280                 285             


Ile Asn Lys Glu Ile Lys Glu Xaa Glu Phe Lys Gly Ile Pro Ile Ser 
    290                 295                 300                 


Tyr Leu Glu Ile His Pro Asn Gly Lys Arg Leu Leu Ile His Xaa Lys 
305                 310                 315                 320 


Asp Ser Xaa Leu Arg Ile Met Asp Leu Arg Ile Leu Val Ala Arg Lys 
                325                 330                 335     


Phe Val Gly Ala Ala Asn Tyr Arg Glu Lys Ile His Ser Xaa Leu Xaa 
            340                 345                 350         


Pro Cys Gly Xaa Phe Leu Phe Ala Gly Ser Glu Asp Gly Ile Val Tyr 
        355                 360                 365             


Val Trp Asn Pro Glu Xaa Gly Glu Gln Val Ala Met Tyr Ser Asp Leu 
    370                 375                 380                 


Pro Phe Lys Ser Pro Ile Arg Asp Ile Ser Tyr His Pro Phe Glu Asn 
385                 390                 395                 400 


Met Val Ala Phe Cys Ala Phe Gly Gln Asn Glu Pro Ile Leu Leu Tyr 
                405                 410                 415     


Ile Tyr Asp Phe His Val Ala Gln Gln Glu Ala Glu Met Phe Lys Arg 
            420                 425                 430         


Tyr Asn Gly Xaa Phe Pro Leu Pro Gly Ile His Gln Ser Gln Asp Ala 
        435                 440                 445             


Leu Cys Xaa Cys Pro Lys Leu Pro His Gln Gly Ser Phe Gln Ile Asp 
    450                 455                 460                 


Glu Phe Val His Xaa Glu Ser Ser Ser Xaa Lys Met Gln Leu Val Lys 
465                 470                 475                 480 


Gln Arg Leu Glu Xaa Val Xaa Glu Val Ile Arg Ser Cys Ala Ala Lys 
                485                 490                 495     


Val Asn Lys Asn Leu Ser Phe Xaa Ser Pro Pro Ala Val Ser Ser Gln 
            500                 505                 510         


Gln Ser Lys Leu Lys Gln Ser Asn Met Leu Xaa Ala Gln Glu Ile Leu 
        515                 520                 525             


His Gln Phe Gly Phe Xaa Gln Xaa Gly Ile Ile Ser Ile Glu Arg Lys 
    530                 535                 540                 


Pro Cys Asn His Gln Val Asp Xaa Ala Pro Xaa Val Val Ala Leu Tyr 
545                 550                 555                 560 


Asp Tyr Xaa Ala Asn Arg Ser Asp Glu Leu Xaa Ile His Arg Gly Asp 
                565                 570                 575     


Ile Ile Arg Val Phe Phe Lys Asp Asn Glu Asp Trp Trp Tyr Gly Ser 
            580                 585                 590         


Ile Gly Lys Gly Gln Glu Gly Tyr Phe Pro Ala Asn His Val Ala Ser 
        595                 600                 605             


Glu Xaa Leu Tyr Gln Glu Leu Pro Pro Glu Ile Lys Glu Arg Ser Pro 
    610                 615                 620                 


Pro Leu Ser Pro Glu Glu Lys Xaa Lys Ile Glu Lys Ser Pro Ala Pro 
625                 630                 635                 640 


Gln Lys Gln Ser Ile Asn Lys Asn Lys Ser Gln Asp Phe Arg Leu Gly 
                645                 650                 655     


Ser Glu Ser Met Xaa His Lys Glu Leu Lys Lys Ser 
            660                 665             


<210> 2020
<211> 542
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<400> 2020
Xaa Ser Leu Asn Ala Gly Glu Arg Gly Cys Phe Cys Leu Asp Phe Ser 
1               5                   10                  15      


His Asn Gly Arg Ile Leu Ala Ala Ala Cys Ala Ser Arg Asp Gly Tyr 
            20                  25                  30          


Pro Ile Ile Leu Tyr Glu Ile Pro Ser Gly Arg Phe Met Arg Glu Leu 
        35                  40                  45              


Cys Gly His Leu Asn Ile Ile Tyr Asp Leu Ser Trp Ser Lys Asp Asp 
    50                  55                  60                  


His Tyr Ile Leu Xaa Ser Ser Ser Asp Gly Xaa Ala Arg Ile Trp Lys 
65                  70                  75                  80  


Asn Glu Ile Asn Asn Xaa Asn Xaa Phe Arg Val Leu Pro His Pro Ser 
                85                  90                  95      


Phe Val Tyr Xaa Ala Lys Phe His Pro Ala Val Arg Glu Leu Val Val 
            100                 105                 110         


Xaa Gly Cys Tyr Asp Ser Met Ile Arg Ile Trp Lys Val Glu Met Arg 
        115                 120                 125             


Glu Asp Ser Ala Ile Leu Val Arg Gln Phe Asp Val His Lys Ser Phe 
    130                 135                 140                 


Ile Asn Ser Leu Cys Phe Asp Xaa Glu Gly His His Met Tyr Ser Gly 
145                 150                 155                 160 


Asp Cys Xaa Gly Val Ile Val Val Trp Asn Xaa Tyr Val Lys Ile Asn 
                165                 170                 175     


Asp Leu Glu His Ser Val His His Trp Xaa Ile Asn Lys Glu Ile Lys 
            180                 185                 190         


Glu Xaa Glu Phe Lys Gly Ile Pro Ile Ser Tyr Leu Glu Ile His Pro 
        195                 200                 205             


Asn Gly Lys Arg Leu Leu Ile His Xaa Lys Asp Ser Xaa Leu Arg Ile 
    210                 215                 220                 


Met Asp Leu Arg Ile Leu Val Ala Arg Lys Phe Val Gly Ala Ala Asn 
225                 230                 235                 240 


Tyr Arg Glu Lys Ile His Ser Xaa Leu Xaa Pro Cys Gly Xaa Phe Leu 
                245                 250                 255     


Phe Ala Gly Ser Glu Asp Gly Ile Val Tyr Val Trp Asn Pro Glu Xaa 
            260                 265                 270         


Gly Glu Gln Val Ala Met Tyr Ser Asp Leu Pro Phe Lys Ser Pro Ile 
        275                 280                 285             


Arg Asp Ile Ser Tyr His Pro Phe Glu Asn Met Val Ala Phe Cys Ala 
    290                 295                 300                 


Phe Gly Gln Asn Glu Pro Ile Leu Leu Tyr Ile Tyr Asp Phe His Val 
305                 310                 315                 320 


Ala Gln Gln Glu Ala Glu Met Phe Lys Arg Tyr Asn Gly Xaa Phe Pro 
                325                 330                 335     


Leu Pro Gly Ile His Gln Ser Gln Asp Ala Leu Cys Xaa Cys Pro Lys 
            340                 345                 350         


Leu Pro His Gln Gly Ser Phe Gln Ile Asp Glu Phe Val His Xaa Glu 
        355                 360                 365             


Ser Ser Ser Xaa Lys Met Gln Leu Val Lys Gln Arg Leu Glu Xaa Val 
    370                 375                 380                 


Xaa Glu Val Ile Arg Ser Cys Ala Ala Lys Val Asn Lys Asn Leu Ser 
385                 390                 395                 400 


Phe Xaa Ser Pro Pro Ala Val Ser Ser Gln Gln Ser Lys Leu Lys Gln 
                405                 410                 415     


Ser Asn Met Leu Xaa Ala Gln Glu Ile Leu His Gln Phe Gly Phe Xaa 
            420                 425                 430         


Gln Xaa Gly Ile Ile Ser Ile Glu Arg Lys Pro Cys Asn His Gln Val 
        435                 440                 445             


Asp Xaa Ala Pro Xaa Val Val Ala Leu Tyr Asp Tyr Xaa Ala Asn Arg 
    450                 455                 460                 


Ser Asp Glu Leu Xaa Ile His Arg Gly Asp Ile Ile Arg Val Phe Phe 
465                 470                 475                 480 


Lys Asp Asn Glu Asp Trp Trp Tyr Gly Ser Ile Gly Lys Gly Gln Glu 
                485                 490                 495     


Gly Tyr Phe Pro Ala Asn His Val Ala Ser Glu Xaa Leu Tyr Gln Glu 
            500                 505                 510         


Leu Pro Pro Glu Ile Lys Glu Arg Ser Pro Pro Leu Ser Pro Glu Glu 
        515                 520                 525             


Lys Xaa Lys Ile Glu Lys Ser Pro Ala Pro Gln Lys Val Lys 
    530                 535                 540         


<210> 2021
<211> 848
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<400> 2021
Met Asn Ser Ser Ser Ala Asn Ile Xaa Tyr Ala Ser Arg Lys Arg Arg 
1               5                   10                  15      


Lys Pro Val Gln Lys Xaa Val Lys Pro Ile Pro Ala Glu Gly Ile Lys 
            20                  25                  30          


Ser Asn Pro Ser Lys Arg His Arg Asp Arg Leu Asn Xaa Glu Leu Asp 
        35                  40                  45              


Arg Leu Ala Ser Leu Leu Pro Phe Pro Gln Asp Val Ile Asn Lys Leu 
    50                  55                  60                  


Asp Lys Leu Ser Val Leu Arg Leu Ser Val Ser Tyr Leu Arg Ala Lys 
65                  70                  75                  80  


Ser Phe Phe Asp Val Ala Leu Lys Ser Ser Pro Xaa Glu Arg Asn Gly 
                85                  90                  95      


Gly Gln Asp Asn Cys Arg Ala Ala Asn Phe Arg Glu Gly Leu Asn Leu 
            100                 105                 110         


Gln Glu Gly Glu Phe Leu Leu Gln Ala Leu Asn Gly Phe Val Leu Val 
        115                 120                 125             


Val Xaa Xaa Asp Ala Leu Val Phe Tyr Ala Ser Ser Xaa Ile Gln Asp 
    130                 135                 140                 


Tyr Leu Gly Phe Gln Gln Ser Asp Val Ile His Gln Ser Val Tyr Glu 
145                 150                 155                 160 


Leu Ile His Xaa Glu Asp Arg Ala Glu Phe Gln Arg Gln Leu His Trp 
                165                 170                 175     


Ala Leu Asn Pro Ser Gln Cys Xaa Glu Ser Gly Gln Gly Ile Glu Glu 
            180                 185                 190         


Ala Xaa Gly Leu Pro Gln Xaa Val Val Cys Tyr Asn Pro Asp Gln Ile 
        195                 200                 205             


Pro Pro Glu Asn Ser Pro Leu Met Glu Arg Cys Phe Ile Cys Arg Leu 
    210                 215                 220                 


Arg Cys Leu Leu Asp Asn Ser Ser Gly Phe Leu Ala Met Asn Phe Gln 
225                 230                 235                 240 


Gly Lys Leu Lys Tyr Leu His Gly Gln Lys Lys Lys Gly Lys Asp Gly 
                245                 250                 255     


Ser Ile Leu Pro Pro Gln Leu Ala Leu Phe Ala Ile Ala Xaa Pro Leu 
            260                 265                 270         


Gln Pro Pro Ser Ile Leu Glu Ile Arg Xaa Lys Asn Phe Ile Phe Arg 
        275                 280                 285             


Xaa Lys His Lys Leu Asp Phe Xaa Pro Ile Gly Cys Asp Ala Lys Gly 
    290                 295                 300                 


Arg Ile Val Leu Gly Tyr Xaa Glu Ala Glu Leu Cys Xaa Arg Gly Ser 
305                 310                 315                 320 


Gly Tyr Gln Phe Ile His Ala Ala Asp Met Leu Tyr Cys Ala Glu Ser 
                325                 330                 335     


His Ile Arg Met Ile Lys Xaa Gly Glu Ser Gly Met Ile Val Phe Arg 
            340                 345                 350         


Leu Leu Xaa Lys Asn Asn Arg Trp Xaa Trp Val Gln Ser Asn Ala Arg 
        355                 360                 365             


Leu Leu Tyr Lys Asn Gly Arg Pro Asp Tyr Ile Ile Val Xaa Gln Arg 
    370                 375                 380                 


Pro Leu Xaa Asp Glu Glu Gly Xaa Glu His Leu Arg Lys Arg Asn Xaa 
385                 390                 395                 400 


Lys Leu Pro Phe Met Phe Xaa Xaa Gly Glu Ala Val Leu Tyr Glu Ala 
                405                 410                 415     


Xaa Asn Pro Phe Pro Ala Ile Met Asp Pro Leu Pro Leu Arg Xaa Lys 
            420                 425                 430         


Asn Gly Xaa Ser Gly Lys Asp Ser Ala Xaa Xaa Ser Xaa Leu Ser Lys 
        435                 440                 445             


Asp Ser Leu Asn Pro Ser Ser Leu Leu Ala Ala Met Met Gln Gln Asp 
    450                 455                 460                 


Glu Ser Ile Tyr Leu Tyr Pro Ala Ser Ser Xaa Ser Ser Xaa Ala Pro 
465                 470                 475                 480 


Phe Glu Asn Asn Phe Phe Asn Glu Ser Met Asn Glu Cys Arg Asn Trp 
                485                 490                 495     


Gln Asp Asn Xaa Ala Pro Met Gly Asn Asp Xaa Ile Leu Lys His Glu 
            500                 505                 510         


Gln Ile Asp Gln Pro Gln Asp Val Asn Ser Phe Ala Gly Gly His Pro 
        515                 520                 525             


Gly Leu Phe Gln Asp Ser Lys Asn Ser Asp Leu Tyr Ser Ile Met Lys 
    530                 535                 540                 


Asn Leu Gly Ile Asp Phe Glu Asp Ile Arg His Met Gln Asn Glu Lys 
545                 550                 555                 560 


Phe Phe Arg Asn Asp Phe Ser Gly Glu Val Asp Phe Arg Asp Ile Asp 
                565                 570                 575     


Leu Xaa Asp Glu Ile Leu Xaa Tyr Val Gln Asp Ser Leu Ser Lys Ser 
            580                 585                 590         


Pro Phe Ile Pro Ser Asp Tyr Gln Gln Gln Gln Ser Leu Ala Leu Asn 
        595                 600                 605             


Ser Ser Cys Met Val Gln Glu His Leu His Leu Glu Gln Gln Gln Gln 
    610                 615                 620                 


His His Gln Lys Gln Val Val Val Glu Pro Gln Gln Gln Leu Cys Gln 
625                 630                 635                 640 


Lys Met Lys His Met Gln Val Asn Gly Met Phe Glu Asn Trp Asn Ser 
                645                 650                 655     


Asn Gln Phe Val Pro Phe Asn Cys Pro Gln Gln Asp Pro Gln Gln Tyr 
            660                 665                 670         


Asn Val Phe Xaa Asp Leu His Gly Ile Ser Gln Glu Phe Pro Tyr Lys 
        675                 680                 685             


Ser Glu Met Asp Ser Met Pro Tyr Xaa Gln Asn Phe Ile Ser Cys Asn 
    690                 695                 700                 


Gln Pro Val Leu Pro Gln His Ser Lys Cys Xaa Glu Leu Asp Tyr Pro 
705                 710                 715                 720 


Met Gly Ser Phe Glu Pro Ser Pro Tyr Pro Xaa Xaa Ser Ser Leu Glu 
                725                 730                 735     


Asp Phe Val Xaa Cys Leu Gln Leu Pro Glu Asn Gln Lys His Gly Leu 
            740                 745                 750         


Asn Pro Gln Ser Ala Ile Ile Xaa Pro Gln Xaa Cys Tyr Ala Gly Ala 
        755                 760                 765             


Val Ser Met Tyr Gln Cys Gln Pro Glu Pro Gln His Xaa His Val Gly 
    770                 775                 780                 


Gln Met Gln Tyr Asn Pro Val Leu Pro Gly Gln Gln Ala Phe Leu Asn 
785                 790                 795                 800 


Lys Phe Gln Asn Gly Val Leu Asn Glu Xaa Tyr Pro Ala Glu Leu Asn 
                805                 810                 815     


Asn Ile Asn Asn Xaa Gln Xaa Xaa Xaa His Leu Gln Pro Leu His His 
            820                 825                 830         


Pro Ser Glu Ala Arg Pro Phe Pro Asp Leu Xaa Ser Ser Gly Phe Leu 
        835                 840                 845             


<210> 2022
<211> 215
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<400> 2022
Leu Leu Pro Ser Ala Ala Glu Met Lys Met Arg Ser Ala Leu Leu Arg 
1               5                   10                  15      


Ala Lys Pro Arg Ala Asp Xaa Ala Ala Xaa Ala Asp Ala Lys Asp Arg 
            20                  25                  30          


Glu Glu Glu Gln His Arg Met Leu Ser Arg Ala Ser Gly Val Xaa Gly 
        35                  40                  45              


Arg Arg Glu Xaa Pro Gly Pro Xaa Lys Pro Leu Pro Trp Xaa Ala Gly 
    50                  55                  60                  


Lys His Ser Glu Asp Gly Ala Arg Pro Arg Leu Gln Pro Ser Lys Asn 
65                  70                  75                  80  


Asp Pro Pro Ser Leu Arg Pro Met Pro Arg Gly Ser Cys Leu Pro Cys 
                85                  90                  95      


Pro Cys Val Gln Gly Xaa Phe Arg Asn Ser Pro Ile Ser His Pro Pro 
            100                 105                 110         


Ser Pro Ser Pro Ser Ala Tyr Ser Ser Arg Xaa Ser Arg Pro Met Arg 
        115                 120                 125             


Asp Val Gly Glu Asp Gln Val His Pro Pro Leu Cys His Phe Pro Gln 
    130                 135                 140                 


Arg Ser Leu Gln His Gln Leu Pro Gln Pro Gly Ala Gln Arg Phe Ala 
145                 150                 155                 160 


Xaa Arg Gly Tyr Pro Met Glu Asp Met Lys Leu Gln Gly Val Pro Met 
                165                 170                 175     


Pro Pro Gly Asp Leu Cys Gly Pro Xaa Leu Leu Leu Asp Val Ser Ile 
            180                 185                 190         


Lys Met Glu Lys Asp Ser Gly Cys Glu Gly Ala Ala Asp Gly Cys Val 
        195                 200                 205             


Pro Ser Gln Val Trp Leu Gly 
    210                 215 


<210> 2023
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2023
Met His Gln Asn Ile Tyr Asp Tyr Ile His Val Asp 
1               5                   10          


<210> 2024
<211> 547
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<400> 2024
Met His Gln Asn Ile Tyr Asp Tyr Ile His Val Asp Asp Arg Gln Asp 
1               5                   10                  15      


Phe Cys Arg Gln Leu His Trp Ala Met Asp Pro Pro Gln Val Val Phe 
            20                  25                  30          


Gly Gln Pro Pro Pro Leu Glu Xaa Gly Asp Asp Ala Ile Leu Gly Arg 
        35                  40                  45              


Leu Leu Arg Ala Gln Glu Trp Gly Xaa Gly Xaa Pro Xaa Glu Tyr Ser 
    50                  55                  60                  


Ala Phe Leu Xaa Arg Cys Phe Ile Cys Arg Val Arg Cys Leu Leu Asp 
65                  70                  75                  80  


Ser Xaa Ser Gly Phe Leu Xaa Met Gln Phe Gln Gly Lys Leu Lys Phe 
                85                  90                  95      


Leu Phe Gly Gln Lys Lys Lys Ala Pro Ser Gly Ala Met Leu Pro Pro 
            100                 105                 110         


Arg Leu Ser Leu Phe Cys Ile Ala Ala Pro Val Leu Leu Pro Ser Ala 
        115                 120                 125             


Ala Glu Met Lys Met Arg Ser Ala Leu Leu Arg Ala Lys Pro Arg Ala 
    130                 135                 140                 


Asp Xaa Ala Ala Xaa Ala Asp Ala Lys Val Lys Ala Xaa Xaa Ser Leu 
145                 150                 155                 160 


Cys Glu Ser Glu Leu His Gly Lys Pro Asn Tyr Ser Ala Gly Arg Ser 
                165                 170                 175     


Ser Arg Glu Ser Gly Val Leu Val Leu Arg Glu Gln Xaa Asp Ala Gly 
            180                 185                 190         


Arg Trp Ala Gln Val Pro Ala Arg Ala Pro Cys Leu Cys Leu Arg Gly 
        195                 200                 205             


Gly Pro Asp Leu Val Leu Asp Pro Lys Gly Gly Ser Gly Asp Arg Glu 
    210                 215                 220                 


Glu Glu Gln His Arg Met Leu Ser Arg Ala Ser Gly Val Xaa Gly Arg 
225                 230                 235                 240 


Arg Glu Xaa Pro Gly Pro Xaa Lys Pro Leu Pro Trp Xaa Ala Gly Lys 
                245                 250                 255     


His Ser Glu Asp Gly Ala Arg Pro Arg Leu Gln Pro Ser Lys Asn Asp 
            260                 265                 270         


Pro Pro Ser Leu Arg Pro Met Pro Arg Gly Ser Cys Leu Pro Cys Pro 
        275                 280                 285             


Cys Val Gln Gly Xaa Phe Arg Asn Ser Pro Ile Ser His Pro Pro Ser 
    290                 295                 300                 


Pro Ser Pro Ser Ala Tyr Ser Ser Arg Xaa Ser Arg Pro Met Arg Asp 
305                 310                 315                 320 


Val Gly Glu Asp Gln Val His Pro Pro Leu Cys His Phe Pro Gln Arg 
                325                 330                 335     


Ser Leu Gln His Gln Leu Pro Gln Pro Gly Ala Gln Arg Phe Ala Xaa 
            340                 345                 350         


Arg Gly Tyr Pro Met Glu Asp Met Lys Leu Gln Gly Val Pro Met Pro 
        355                 360                 365             


Pro Gly Asp Leu Cys Gly Pro Xaa Leu Leu Leu Asp Val Ser Ile Lys 
    370                 375                 380                 


Met Glu Lys Asp Ser Gly Cys Glu Gly Ala Ala Asp Gly Cys Val Pro 
385                 390                 395                 400 


Ser Gln Val Trp Leu Gly Ala Ser Asp Arg Ser His Pro Ala Xaa Phe 
                405                 410                 415     


Pro Xaa Arg Met His Leu Lys Xaa Glu Pro Asp Ser Arg Gln Gln Val 
            420                 425                 430         


Tyr Ile Ser His Leu Gly His Gly Val Arg Gly Ala Gln Pro His Gly 
        435                 440                 445             


Arg Ala Xaa Ala Gly Arg Ser Arg Glu Leu Xaa Pro Phe His Pro Ala 
    450                 455                 460                 


His Cys Ala Cys Leu Glu Pro Xaa Asp Gly Leu Pro Gln Ser Glu Pro 
465                 470                 475                 480 


Pro His Gln Leu Cys Ala Arg Gly Arg Gly Glu Gln Ser Cys Xaa Cys 
                485                 490                 495     


Arg Ala Ala Glu Ala Ala Pro Val Val Lys Arg Glu Pro Leu Asp Ser 
            500                 505                 510         


Pro Gln Trp Ala Xaa His Ser Gln Gly Met Val Pro Gly Met Leu Pro 
        515                 520                 525             


Lys Ser Ala Leu Ala Xaa Leu Val Pro Pro Gln Ala Ser Gly Cys Xaa 
    530                 535                 540                 


Phe Leu Pro 
545         


<210> 2025
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<400> 2025
Met Ile Pro Pro Gly Glu Cys Xaa Tyr Ala Gly Arg Lys Arg Arg Arg 
1               5                   10                  15      


Pro Leu Gln Lys Gln Arg Pro Ala Val Gly Ala Glu Lys Ser Asn Pro 
            20                  25                  30          


Ser Lys Arg His Arg Asp Arg Leu Asn Ala Glu Leu Asp His Leu Ala 
        35                  40                  45              


Ser Leu Leu Pro Phe Pro Pro Asp Ile Ile Ser Lys Leu Asp Lys Leu 
    50                  55                  60                  


Ser Val Leu Arg Leu Ser Val Ser Tyr Leu Arg Val Lys Ser Phe Phe 
65                  70                  75                  80  


Gln 
    


<210> 2026
<211> 139
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 2026
Met Ile Pro Pro Gly Glu Cys Xaa Tyr Ala Gly Arg Lys Arg Arg Arg 
1               5                   10                  15      


Pro Leu Gln Lys Gln Arg Pro Ala Val Gly Ala Glu Lys Ser Asn Pro 
            20                  25                  30          


Ser Lys Arg His Arg Asp Arg Leu Asn Ala Glu Leu Asp His Leu Ala 
        35                  40                  45              


Ser Leu Leu Pro Phe Pro Pro Asp Ile Ile Ser Lys Leu Asp Lys Leu 
    50                  55                  60                  


Ser Val Leu Arg Leu Ser Val Ser Tyr Leu Arg Val Lys Ser Phe Phe 
65                  70                  75                  80  


Gln Gly Gln Gly Leu Ala Val Ala Asp Ala Glu Asp Val Asp Asp His 
                85                  90                  95      


Xaa Gly Glu Arg Arg Pro Met Ser Phe Arg Arg Pro Arg Ala Leu Asp 
            100                 105                 110         


Xaa Gln Ala Leu Arg Arg Xaa Gln Phe Gly Leu His Leu Leu Met Val 
        115                 120                 125             


Asn Ile Ala Gly Leu Ile Ala Xaa Asp Arg Leu 
    130                 135                 


<210> 2027
<211> 157
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 2027
Met Ile Pro Pro Gly Glu Cys Xaa Tyr Ala Gly Arg Lys Arg Arg Arg 
1               5                   10                  15      


Pro Leu Gln Lys Gln Arg Pro Ala Val Gly Ala Glu Lys Ser Asn Pro 
            20                  25                  30          


Ser Lys Arg His Arg Asp Arg Leu Asn Ala Glu Leu Asp His Leu Ala 
        35                  40                  45              


Ser Leu Leu Pro Phe Pro Pro Asp Ile Ile Ser Lys Leu Asp Lys Leu 
    50                  55                  60                  


Ser Val Leu Arg Leu Ser Val Ser Tyr Leu Arg Val Lys Ser Phe Phe 
65                  70                  75                  80  


Gln Val Val Gln Glu Gln Ser Ser Arg Gln Pro Ala Ala Gly Ala Pro 
                85                  90                  95      


Ser Pro Gly Asp Ser Cys Pro Leu Ala Gly Ser Ala Val Leu Glu Gly 
            100                 105                 110         


Arg Leu Leu Leu Glu Ser Leu Asn Gly Phe Ala Leu Val Val Ser Ala 
        115                 120                 125             


Glu Gly Xaa Ile Phe Tyr Ala Ser Ala Xaa Ile Val Asp Tyr Leu Gly 
    130                 135                 140                 


Phe His Gln Xaa Asp Val Met His Gln Asn Ile Tyr Asp 
145                 150                 155         


<210> 2028
<211> 719
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<400> 2028
Met Pro Arg Xaa Met Ile Pro Pro Gly Glu Cys Xaa Tyr Ala Gly Arg 
1               5                   10                  15      


Lys Arg Arg Arg Pro Leu Gln Lys Gln Arg Pro Ala Val Gly Ala Glu 
            20                  25                  30          


Lys Ser Asn Pro Ser Lys Arg His Arg Asp Arg Leu Asn Ala Glu Leu 
        35                  40                  45              


Asp His Leu Ala Ser Leu Leu Pro Phe Pro Pro Asp Ile Ile Ser Lys 
    50                  55                  60                  


Leu Asp Lys Leu Ser Val Leu Arg Leu Ser Val Ser Tyr Leu Arg Val 
65                  70                  75                  80  


Lys Ser Phe Phe Gln Val Val Gln Glu Gln Ser Ser Arg Gln Pro Ala 
                85                  90                  95      


Ala Gly Ala Pro Ser Pro Gly Asp Ser Cys Pro Leu Ala Gly Ser Ala 
            100                 105                 110         


Val Leu Glu Gly Arg Leu Leu Leu Glu Ser Leu Asn Gly Phe Ala Leu 
        115                 120                 125             


Val Val Ser Ala Glu Gly Xaa Ile Phe Tyr Ala Ser Ala Xaa Ile Val 
    130                 135                 140                 


Asp Tyr Leu Gly Phe His Gln Xaa Asp Val Met His Gln Asn Ile Tyr 
145                 150                 155                 160 


Asp Tyr Ile His Val Asp Asp Arg Gln Asp Phe Cys Arg Gln Leu His 
                165                 170                 175     


Trp Ala Met Asp Pro Pro Gln Val Val Phe Gly Gln Pro Pro Pro Leu 
            180                 185                 190         


Glu Xaa Gly Asp Asp Ala Ile Leu Gly Arg Leu Leu Arg Ala Gln Glu 
        195                 200                 205             


Trp Gly Xaa Gly Xaa Pro Xaa Glu Tyr Ser Ala Phe Leu Xaa Arg Cys 
    210                 215                 220                 


Phe Ile Cys Arg Val Arg Cys Leu Leu Asp Ser Xaa Ser Gly Phe Leu 
225                 230                 235                 240 


Ala Arg Gly Ser Gln Ala Trp Gln Leu Arg Leu Cys Cys Pro Glu Pro 
                245                 250                 255     


Leu Met Xaa Met Gln Phe Gln Gly Lys Leu Lys Phe Leu Phe Gly Gln 
            260                 265                 270         


Lys Lys Lys Ala Pro Ser Gly Ala Met Leu Pro Pro Arg Leu Ser Leu 
        275                 280                 285             


Phe Cys Ile Ala Ala Pro Val Leu Leu Pro Ser Ala Ala Glu Met Lys 
    290                 295                 300                 


Met Arg Ser Ala Leu Leu Arg Ala Lys Pro Arg Ala Asp Xaa Ala Ala 
305                 310                 315                 320 


Xaa Ala Asp Ala Lys Val Lys Ala Xaa Xaa Ser Leu Cys Glu Ser Glu 
                325                 330                 335     


Leu His Gly Lys Pro Asn Tyr Ser Ala Gly Arg Ser Ser Arg Glu Ser 
            340                 345                 350         


Gly Val Leu Val Leu Arg Glu Gln Xaa Asp Ala Gly Arg Trp Ala Gln 
        355                 360                 365             


Val Pro Ala Arg Ala Pro Cys Leu Cys Leu Arg Gly Gly Pro Asp Leu 
    370                 375                 380                 


Val Leu Asp Pro Lys Gly Gly Ser Gly Asp Arg Glu Glu Glu Gln His 
385                 390                 395                 400 


Arg Met Leu Ser Arg Ala Ser Gly Val Xaa Gly Arg Arg Glu Xaa Pro 
                405                 410                 415     


Gly Pro Xaa Lys Pro Leu Pro Trp Xaa Ala Gly Lys His Ser Glu Asp 
            420                 425                 430         


Gly Ala Arg Pro Arg Leu Gln Pro Ser Lys Asn Asp Pro Pro Ser Leu 
        435                 440                 445             


Arg Pro Met Pro Arg Gly Ser Cys Leu Pro Cys Pro Cys Val Gln Gly 
    450                 455                 460                 


Xaa Phe Arg Asn Ser Pro Ile Ser His Pro Pro Ser Pro Ser Pro Ser 
465                 470                 475                 480 


Ala Tyr Ser Ser Arg Xaa Ser Arg Pro Met Arg Asp Val Gly Glu Asp 
                485                 490                 495     


Gln Val His Pro Pro Leu Cys His Phe Pro Gln Arg Ser Leu Gln His 
            500                 505                 510         


Gln Leu Pro Gln Pro Gly Ala Gln Arg Phe Ala Xaa Arg Gly Tyr Pro 
        515                 520                 525             


Met Glu Asp Met Lys Leu Gln Gly Val Pro Met Pro Pro Gly Asp Leu 
    530                 535                 540                 


Cys Gly Pro Xaa Leu Leu Leu Asp Val Ser Ile Lys Met Glu Lys Asp 
545                 550                 555                 560 


Ser Gly Cys Glu Gly Ala Ala Asp Gly Cys Val Pro Ser Gln Val Trp 
                565                 570                 575     


Leu Gly Ala Ser Asp Arg Ser His Pro Ala Xaa Phe Pro Xaa Arg Met 
            580                 585                 590         


His Leu Lys Xaa Glu Pro Asp Ser Arg Gln Gln Val Tyr Ile Ser His 
        595                 600                 605             


Leu Gly His Gly Val Arg Gly Ala Gln Pro His Gly Arg Ala Xaa Ala 
    610                 615                 620                 


Gly Arg Ser Arg Glu Leu Xaa Pro Phe His Pro Ala His Cys Ala Cys 
625                 630                 635                 640 


Leu Glu Pro Xaa Asp Gly Leu Pro Gln Ser Glu Pro Pro His Gln Leu 
                645                 650                 655     


Cys Ala Arg Gly Arg Gly Glu Gln Ser Cys Xaa Cys Arg Ala Ala Glu 
            660                 665                 670         


Ala Ala Pro Val Val Lys Arg Glu Pro Leu Asp Ser Pro Gln Trp Ala 
        675                 680                 685             


Xaa His Ser Gln Gly Met Val Pro Gly Met Leu Pro Lys Ser Ala Leu 
    690                 695                 700                 


Ala Xaa Leu Val Pro Pro Gln Ala Ser Gly Cys Xaa Phe Leu Pro 
705                 710                 715                 


<210> 2029
<211> 701
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<400> 2029
Met Pro Arg Xaa Met Ile Pro Pro Gly Glu Cys Xaa Tyr Ala Gly Arg 
1               5                   10                  15      


Lys Arg Arg Arg Pro Leu Gln Lys Gln Arg Pro Ala Val Gly Ala Glu 
            20                  25                  30          


Lys Ser Asn Pro Ser Lys Arg His Arg Asp Arg Leu Asn Ala Glu Leu 
        35                  40                  45              


Asp His Leu Ala Ser Leu Leu Pro Phe Pro Pro Asp Ile Ile Ser Lys 
    50                  55                  60                  


Leu Asp Lys Leu Ser Val Leu Arg Leu Ser Val Ser Tyr Leu Arg Val 
65                  70                  75                  80  


Lys Ser Phe Phe Gln Val Val Gln Glu Gln Ser Ser Arg Gln Pro Ala 
                85                  90                  95      


Ala Gly Ala Pro Ser Pro Gly Asp Ser Cys Pro Leu Ala Gly Ser Ala 
            100                 105                 110         


Val Leu Glu Gly Arg Leu Leu Leu Glu Ser Leu Asn Gly Phe Ala Leu 
        115                 120                 125             


Val Val Ser Ala Glu Gly Xaa Ile Phe Tyr Ala Ser Ala Xaa Ile Val 
    130                 135                 140                 


Asp Tyr Leu Gly Phe His Gln Xaa Asp Val Met His Gln Asn Ile Tyr 
145                 150                 155                 160 


Asp Tyr Ile His Val Asp Asp Arg Gln Asp Phe Cys Arg Gln Leu His 
                165                 170                 175     


Trp Ala Met Asp Pro Pro Gln Val Val Phe Gly Gln Pro Pro Pro Leu 
            180                 185                 190         


Glu Xaa Gly Asp Asp Ala Ile Leu Gly Arg Leu Leu Arg Ala Gln Glu 
        195                 200                 205             


Trp Gly Xaa Gly Xaa Pro Xaa Glu Tyr Ser Ala Phe Leu Xaa Arg Cys 
    210                 215                 220                 


Phe Ile Cys Arg Val Arg Cys Leu Leu Asp Ser Xaa Ser Gly Phe Leu 
225                 230                 235                 240 


Xaa Met Gln Phe Gln Gly Lys Leu Lys Phe Leu Phe Gly Gln Lys Lys 
                245                 250                 255     


Lys Ala Pro Ser Gly Ala Met Leu Pro Pro Arg Leu Ser Leu Phe Cys 
            260                 265                 270         


Ile Ala Ala Pro Val Leu Leu Pro Ser Ala Ala Glu Met Lys Met Arg 
        275                 280                 285             


Ser Ala Leu Leu Arg Ala Lys Pro Arg Ala Asp Xaa Ala Ala Xaa Ala 
    290                 295                 300                 


Asp Ala Lys Val Lys Ala Xaa Xaa Ser Leu Cys Glu Ser Glu Leu His 
305                 310                 315                 320 


Gly Lys Pro Asn Tyr Ser Ala Gly Arg Ser Ser Arg Glu Ser Gly Val 
                325                 330                 335     


Leu Val Leu Arg Glu Gln Xaa Asp Ala Gly Arg Trp Ala Gln Val Pro 
            340                 345                 350         


Ala Arg Ala Pro Cys Leu Cys Leu Arg Gly Gly Pro Asp Leu Val Leu 
        355                 360                 365             


Asp Pro Lys Gly Gly Ser Gly Asp Arg Glu Glu Glu Gln His Arg Met 
    370                 375                 380                 


Leu Ser Arg Ala Ser Gly Val Xaa Gly Arg Arg Glu Xaa Pro Gly Pro 
385                 390                 395                 400 


Xaa Lys Pro Leu Pro Trp Xaa Ala Gly Lys His Ser Glu Asp Gly Ala 
                405                 410                 415     


Arg Pro Arg Leu Gln Pro Ser Lys Asn Asp Pro Pro Ser Leu Arg Pro 
            420                 425                 430         


Met Pro Arg Gly Ser Cys Leu Pro Cys Pro Cys Val Gln Gly Xaa Phe 
        435                 440                 445             


Arg Asn Ser Pro Ile Ser His Pro Pro Ser Pro Ser Pro Ser Ala Tyr 
    450                 455                 460                 


Ser Ser Arg Xaa Ser Arg Pro Met Arg Asp Val Gly Glu Asp Gln Val 
465                 470                 475                 480 


His Pro Pro Leu Cys His Phe Pro Gln Arg Ser Leu Gln His Gln Leu 
                485                 490                 495     


Pro Gln Pro Gly Ala Gln Arg Phe Ala Xaa Arg Gly Tyr Pro Met Glu 
            500                 505                 510         


Asp Met Lys Leu Gln Gly Val Pro Met Pro Pro Gly Asp Leu Cys Gly 
        515                 520                 525             


Pro Xaa Leu Leu Leu Asp Val Ser Ile Lys Met Glu Lys Asp Ser Gly 
    530                 535                 540                 


Cys Glu Gly Ala Ala Asp Gly Cys Val Pro Ser Gln Val Trp Leu Gly 
545                 550                 555                 560 


Ala Ser Asp Arg Ser His Pro Ala Xaa Phe Pro Xaa Arg Met His Leu 
                565                 570                 575     


Lys Xaa Glu Pro Asp Ser Arg Gln Gln Val Tyr Ile Ser His Leu Gly 
            580                 585                 590         


His Gly Val Arg Gly Ala Gln Pro His Gly Arg Ala Xaa Ala Gly Arg 
        595                 600                 605             


Ser Arg Glu Leu Xaa Pro Phe His Pro Ala His Cys Ala Cys Leu Glu 
    610                 615                 620                 


Pro Xaa Asp Gly Leu Pro Gln Ser Glu Pro Pro His Gln Leu Cys Ala 
625                 630                 635                 640 


Arg Gly Arg Gly Glu Gln Ser Cys Xaa Cys Arg Ala Ala Glu Ala Ala 
                645                 650                 655     


Pro Val Val Lys Arg Glu Pro Leu Asp Ser Pro Gln Trp Ala Xaa His 
            660                 665                 670         


Ser Gln Gly Met Val Pro Gly Met Leu Pro Lys Ser Ala Leu Ala Xaa 
        675                 680                 685             


Leu Val Pro Pro Gln Ala Ser Gly Cys Xaa Phe Leu Pro 
    690                 695                 700     


<210> 2030
<211> 557
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<400> 2030
Met Arg Gly Arg Gly Met Pro Xaa Asp Val Met His Gln Asn Ile Tyr 
1               5                   10                  15      


Asp Tyr Ile His Val Asp Asp Arg Gln Asp Phe Cys Arg Gln Leu His 
            20                  25                  30          


Trp Ala Met Asp Pro Pro Gln Val Val Phe Gly Gln Pro Pro Pro Leu 
        35                  40                  45              


Glu Xaa Gly Asp Asp Ala Ile Leu Gly Arg Leu Leu Arg Ala Gln Glu 
    50                  55                  60                  


Trp Gly Xaa Gly Xaa Pro Xaa Glu Tyr Ser Ala Phe Leu Xaa Arg Cys 
65                  70                  75                  80  


Phe Ile Cys Arg Val Arg Cys Leu Leu Asp Ser Xaa Ser Gly Phe Leu 
                85                  90                  95      


Xaa Met Gln Phe Gln Gly Lys Leu Lys Phe Leu Phe Gly Gln Lys Lys 
            100                 105                 110         


Lys Ala Pro Ser Gly Ala Met Leu Pro Pro Arg Leu Ser Leu Phe Cys 
        115                 120                 125             


Ile Ala Ala Pro Val Leu Leu Pro Ser Ala Ala Glu Met Lys Met Arg 
    130                 135                 140                 


Ser Ala Leu Leu Arg Ala Lys Pro Arg Ala Asp Xaa Ala Ala Xaa Ala 
145                 150                 155                 160 


Asp Ala Lys Val Lys Ala Xaa Xaa Ser Leu Cys Glu Ser Glu Leu His 
                165                 170                 175     


Gly Lys Pro Asn Tyr Ser Ala Gly Arg Ser Ser Arg Glu Ser Gly Val 
            180                 185                 190         


Leu Val Leu Arg Glu Gln Xaa Asp Ala Gly Arg Trp Ala Gln Val Pro 
        195                 200                 205             


Ala Arg Ala Pro Cys Leu Cys Leu Arg Gly Gly Pro Asp Leu Val Leu 
    210                 215                 220                 


Asp Pro Lys Gly Gly Ser Gly Asp Arg Glu Glu Glu Gln His Arg Met 
225                 230                 235                 240 


Leu Ser Arg Ala Ser Gly Val Xaa Gly Arg Arg Glu Xaa Pro Gly Pro 
                245                 250                 255     


Xaa Lys Pro Leu Pro Trp Xaa Ala Gly Lys His Ser Glu Asp Gly Ala 
            260                 265                 270         


Arg Pro Arg Leu Gln Pro Ser Lys Asn Asp Pro Pro Ser Leu Arg Pro 
        275                 280                 285             


Met Pro Arg Gly Ser Cys Leu Pro Cys Pro Cys Val Gln Gly Xaa Phe 
    290                 295                 300                 


Arg Asn Ser Pro Ile Ser His Pro Pro Ser Pro Ser Pro Ser Ala Tyr 
305                 310                 315                 320 


Ser Ser Arg Xaa Ser Arg Pro Met Arg Asp Val Gly Glu Asp Gln Val 
                325                 330                 335     


His Pro Pro Leu Cys His Phe Pro Gln Arg Ser Leu Gln His Gln Leu 
            340                 345                 350         


Pro Gln Pro Gly Ala Gln Arg Phe Ala Xaa Arg Gly Tyr Pro Met Glu 
        355                 360                 365             


Asp Met Lys Leu Gln Gly Val Pro Met Pro Pro Gly Asp Leu Cys Gly 
    370                 375                 380                 


Pro Xaa Leu Leu Leu Asp Val Ser Ile Lys Met Glu Lys Asp Ser Gly 
385                 390                 395                 400 


Cys Glu Gly Ala Ala Asp Gly Cys Val Pro Ser Gln Val Trp Leu Gly 
                405                 410                 415     


Ala Ser Asp Arg Ser His Pro Ala Xaa Phe Pro Xaa Arg Met His Leu 
            420                 425                 430         


Lys Xaa Glu Pro Asp Ser Arg Gln Gln Val Tyr Ile Ser His Leu Gly 
        435                 440                 445             


His Gly Val Arg Gly Ala Gln Pro His Gly Arg Ala Xaa Ala Gly Arg 
    450                 455                 460                 


Ser Arg Glu Leu Xaa Pro Phe His Pro Ala His Cys Ala Cys Leu Glu 
465                 470                 475                 480 


Pro Xaa Asp Gly Leu Pro Gln Ser Glu Pro Pro His Gln Leu Cys Ala 
                485                 490                 495     


Arg Gly Arg Gly Glu Gln Ser Cys Xaa Cys Arg Ala Ala Glu Ala Ala 
            500                 505                 510         


Pro Val Val Lys Arg Glu Pro Leu Asp Ser Pro Gln Trp Ala Xaa His 
        515                 520                 525             


Ser Gln Gly Met Val Pro Gly Met Leu Pro Lys Ser Ala Leu Ala Xaa 
    530                 535                 540                 


Leu Val Pro Pro Gln Ala Ser Gly Cys Xaa Phe Leu Pro 
545                 550                 555         


<210> 2031
<211> 368
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<400> 2031
Met Lys Ser Leu Val Leu Leu Leu Cys Leu Ala Gln Leu Trp Gly Cys 
1               5                   10                  15      


His Ser Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys 
            20                  25                  30          


Asp Asp Pro Glu Xaa Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile 
        35                  40                  45              


Asn Gln Asn Leu Pro Trp Gly Tyr Lys His Xaa Leu Asn Gln Ile Asp 
    50                  55                  60                  


Glu Val Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile 
65                  70                  75                  80  


Glu Ile Asp Xaa Leu Glu Xaa Xaa Cys His Val Leu Asp Pro Xaa Pro 
                85                  90                  95      


Val Ala Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly 
            100                 105                 110         


Asp Cys Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val 
        115                 120                 125             


Tyr Ala Lys Cys Asp Ser Ser Pro Ala Asp Ser Ala Glu Asp Val Arg 
    130                 135                 140                 


Lys Val Cys Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Xaa Arg 
145                 150                 155                 160 


Val Val His Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn 
                165                 170                 175     


Asn Gly Ser Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val 
            180                 185                 190         


Pro Leu Pro Pro Ser Xaa Tyr Val Glu Phe Xaa Val Ser Gly Xaa Asp 
        195                 200                 205             


Cys Val Ala Lys Glu Ala Xaa Glu Ala Ala Lys Cys Asn Leu Leu Ala 
    210                 215                 220                 


Glu Lys Gln Tyr Gly Phe Cys Lys Ala Xaa Leu Ser Glu Lys Leu Gly 
225                 230                 235                 240 


Gly Ala Glu Val Ala Val Xaa Cys Met Val Phe Gln Xaa Gln Pro Val 
                245                 250                 255     


Ser Ser Gln Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Xaa Pro 
            260                 265                 270         


Val Val Asp Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly 
        275                 280                 285             


Leu Pro Pro Ala Gly Ser Pro Pro Asp Ser His Val Leu Leu Ala Ala 
    290                 295                 300                 


Pro Pro Gly His Gln Leu His Arg Ala His Tyr Asp Leu Arg His Xaa 
305                 310                 315                 320 


Phe Met Gly Val Val Ser Leu Gly Ser Pro Ser Gly Glu Val Ser His 
                325                 330                 335     


Pro Arg Lys Xaa Arg Xaa Val Val Gln Pro Ser Val Gly Ala Ala Ala 
            340                 345                 350         


Gly Pro Val Val Pro Pro Cys Pro Gly Arg Ile Arg His Phe Lys Val 
        355                 360                 365             


<210> 2032
<211> 367
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<400> 2032
Met Lys Ser Leu Val Leu Leu Leu Cys Leu Ala Gln Leu Trp Gly Cys 
1               5                   10                  15      


His Ser Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys 
            20                  25                  30          


Asp Asp Pro Glu Xaa Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile 
        35                  40                  45              


Asn Gln Asn Leu Pro Trp Gly Tyr Lys His Xaa Leu Asn Gln Ile Asp 
    50                  55                  60                  


Glu Val Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile 
65                  70                  75                  80  


Glu Ile Asp Xaa Leu Glu Xaa Xaa Cys His Val Leu Asp Pro Xaa Pro 
                85                  90                  95      


Val Ala Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly 
            100                 105                 110         


Asp Cys Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val 
        115                 120                 125             


Tyr Ala Lys Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys 
    130                 135                 140                 


Val Cys Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Xaa Arg Val 
145                 150                 155                 160 


Val His Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn 
                165                 170                 175     


Gly Ser Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro 
            180                 185                 190         


Leu Pro Pro Ser Xaa Tyr Val Glu Phe Xaa Val Ser Gly Xaa Asp Cys 
        195                 200                 205             


Val Ala Lys Glu Ala Xaa Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu 
    210                 215                 220                 


Lys Gln Tyr Gly Phe Cys Lys Ala Xaa Leu Ser Glu Lys Leu Gly Gly 
225                 230                 235                 240 


Ala Glu Val Ala Val Xaa Cys Met Val Phe Gln Xaa Gln Pro Val Ser 
                245                 250                 255     


Ser Gln Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Xaa Pro Val 
            260                 265                 270         


Val Asp Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu 
        275                 280                 285             


Pro Pro Ala Gly Ser Pro Pro Asp Ser His Val Leu Leu Ala Ala Pro 
    290                 295                 300                 


Pro Gly His Gln Leu His Arg Ala His Tyr Asp Leu Arg His Xaa Phe 
305                 310                 315                 320 


Met Gly Val Val Ser Leu Gly Ser Pro Ser Gly Glu Val Ser His Pro 
                325                 330                 335     


Arg Lys Xaa Arg Xaa Val Val Gln Pro Ser Val Gly Ala Ala Ala Gly 
            340                 345                 350         


Pro Val Val Pro Pro Cys Pro Gly Arg Ile Arg His Phe Lys Val 
        355                 360                 365         


<210> 2033
<211> 161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<400> 2033
Gly Arg Lys Ala Ser Glu Lys Xaa Gly Gly Arg Glu Gly Glu Pro Ala 
1               5                   10                  15      


Asp Arg Gly Leu Gln Leu Gly Gly Lys Ala Phe Gly Leu Leu Lys Ala 
            20                  25                  30          


Gln Gln Glu Glu Arg Leu Asp Glu Ile Asn Lys Gln Phe Leu Asp Asp 
        35                  40                  45              


Pro Lys Tyr Ser Ser Asp Glu Asp Leu Pro Ser Lys Leu Glu Gly Phe 
    50                  55                  60                  


Lys Glu Lys Tyr Met Glu Phe Asp Leu Asn Gly Asn Gly Asp Ile Asp 
65                  70                  75                  80  


Ile Met Ser Leu Lys Arg Met Leu Glu Lys Leu Gly Val Pro Lys Xaa 
                85                  90                  95      


His Leu Glu Leu Lys Lys Leu Ile Gly Glu Val Ser Ser Gly Ser Gly 
            100                 105                 110         


Glu Xaa Phe Ser Tyr Pro Asp Phe Leu Arg Met Met Leu Gly Lys Arg 
        115                 120                 125             


Ser Ala Ile Leu Lys Met Ile Leu Met Tyr Glu Glu Lys Ala Arg Glu 
    130                 135                 140                 


Lys Glu Lys Pro Xaa Gly Pro Pro Ala Lys Lys Ala Ile Ser Glu Leu 
145                 150                 155                 160 


Pro 
    


<210> 2034
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 2034
Met Glu Phe Asp Leu Asn Gly Asn Gly Asp Ile Asp Ile Met Ser Leu 
1               5                   10                  15      


Lys Arg Met Leu Glu Lys Leu Gly Val Pro Lys Xaa His Leu Glu Leu 
            20                  25                  30          


Lys Lys Leu Ile Gly Glu Val Ser Ser Gly Ser Gly Glu Xaa Phe Ser 
        35                  40                  45              


Tyr Pro Asp Phe Leu Arg Met Met Leu Gly Lys Arg Ser Ala Ile Leu 
    50                  55                  60                  


Lys Met Ile Leu Met Tyr Glu Glu Lys Ala Arg Glu Lys Glu Lys Pro 
65                  70                  75                  80  


Xaa Gly Pro Pro Ala Lys Lys Ala Ile Ser Glu Leu Pro 
                85                  90              


<210> 2035
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<400> 2035
Met Ser Gln Xaa Arg Asp Leu Gln Gly Gly Lys Ala Phe Gly Leu Leu 
1               5                   10                  15      


Lys Ala Gln Gln Glu Glu Arg Leu Asp Glu Ile Asn Lys Gln Phe Leu 
            20                  25                  30          


Asp Asp Pro Lys Tyr Ser Ser Asp Glu Asp Leu Pro Ser Lys Leu Glu 
        35                  40                  45              


Gly Phe Lys Glu Lys Tyr Met Glu Phe Asp Leu Asn Gly Asn Gly Asp 
    50                  55                  60                  


Ile Asp Ile Met Ser Leu Lys Arg Met Leu Glu Lys Leu Gly Val Pro 
65                  70                  75                  80  


Lys Xaa His Leu Glu Leu Lys Lys Leu Ile Gly Glu Val Ser Ser Gly 
                85                  90                  95      


Ser Gly Glu Xaa Phe Ser Tyr Pro Asp Phe Leu Arg Met Met Leu Gly 
            100                 105                 110         


Lys Arg Ser Ala Ile Leu Lys Met Ile Leu Met Tyr Glu Glu Lys Ala 
        115                 120                 125             


Arg Glu Lys Glu Lys Pro Xaa Gly Pro Pro Ala Lys Lys Ala Ile Ser 
    130                 135                 140                 


Glu Leu Pro 
145         


<210> 2036
<211> 326
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<400> 2036
Met Phe Arg Cys Gly Gly Leu Ala Ala Gly Ala Leu Lys Gln Lys Leu 
1               5                   10                  15      


Val Pro Leu Val Arg Xaa Val Cys Val Arg Ser Pro Arg Gln Arg Asn 
            20                  25                  30          


Arg Leu Pro Ala Arg Ala Leu Gly Xaa Glu Val Ile Gln Leu Phe Pro 
        35                  40                  45              


Glu Lys Gly Asn Met Gly Lys Ile Leu Pro Glu Tyr Leu Ser Asn Trp 
    50                  55                  60                  


Xaa Met Glu Lys Val Arg Arg Glu Gly Val Lys Val Met Pro Asn Ala 
65                  70                  75                  80  


Ile Val Gln Ser Val Gly Val Ser Ser Gly Lys Leu Leu Ile Lys Leu 
                85                  90                  95      


Lys Asp Gly Arg Lys Val Glu Xaa Asp His Ile Val Ala Ala Val Gly 
            100                 105                 110         


Leu Glu Pro Asn Val Glu Leu Ala Lys Xaa Gly Gly Leu Glu Ile Asp 
        115                 120                 125             


Ser Asp Phe Gly Gly Phe Arg Val Asn Ala Glu Leu Gln Ala Arg Ser 
    130                 135                 140                 


Asn Ile Trp Val Ala Gly Asp Ala Ala Cys Phe Tyr Asp Ile Lys Leu 
145                 150                 155                 160 


Gly Arg Arg Arg Val Glu His His Asp His Ala Val Val Ser Gly Arg 
                165                 170                 175     


Leu Ala Gly Glu Asn Met Xaa Gly Ala Ala Lys Pro Tyr Trp His Gln 
            180                 185                 190         


Ser Met Phe Trp Ser Asp Leu Gly Pro Asp Val Gly Tyr Glu Ala Ile 
        195                 200                 205             


Gly Leu Val Asp Ser Ser Leu Pro Xaa Val Gly Val Phe Ala Lys Ala 
    210                 215                 220                 


Xaa Ala Gln Asp Asn Pro Lys Ser Ala Xaa Glu Gln Ser Gly Xaa Gly 
225                 230                 235                 240 


Ile Arg Ser Glu Ser Glu Xaa Glu Ser Glu Ala Ser Glu Ile Xaa Ile 
                245                 250                 255     


Pro Pro Ser Xaa Pro Ala Val Pro Gln Ala Pro Val Gln Gly Glu Asp 
            260                 265                 270         


Tyr Gly Lys Gly Val Ile Phe Tyr Leu Arg Asp Lys Val Val Val Gly 
        275                 280                 285             


Ile Val Leu Trp Asn Ile Phe Asn Arg Met Pro Ile Ala Arg Lys Ile 
    290                 295                 300                 


Ile Lys Asp Gly Glu Gln His Glu Asp Leu Asn Glu Val Ala Lys Leu 
305                 310                 315                 320 


Phe Asn Ile His Glu Asp 
                325     


<210> 2037
<211> 43
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<400> 2037
Met Phe Arg Cys Gly Gly Leu Ala Ala Gly Ala Leu Lys Gln Lys Leu 
1               5                   10                  15      


Val Pro Leu Val Arg Xaa Val Cys Val Arg Ser Pro Arg Gln Arg Asn 
            20                  25                  30          


Arg Leu Pro Gly Leu Gln Asp Tyr Glu Arg Gly 
        35                  40              


<210> 2038
<211> 324
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<400> 2038
Met Phe Arg Cys Gly Gly Leu Ala Ala Gly Ala Leu Lys Gln Lys Leu 
1               5                   10                  15      


Val Pro Leu Val Arg Xaa Val Cys Val Arg Ser Pro Arg Gln Arg Asn 
            20                  25                  30          


Arg Leu Pro Gly Asn Leu Phe Gln Arg Trp His Val Pro Leu Glu Leu 
        35                  40                  45              


Gln Met Xaa Arg Gln Met Ala Ser Ser Gly Ala Ser Gly Gly Lys Ile 
    50                  55                  60                  


Asp Asn Ser Val Leu Val Leu Ile Val Gly Leu Ser Xaa Val Gly Ala 
65                  70                  75                  80  


Gly Ala Tyr Ala Tyr Lys Xaa Met Lys Glu Asp Glu Lys Arg Tyr Asn 
                85                  90                  95      


Glu Arg Ile Ser Gly Leu Gly Leu Xaa Pro Glu Gln Lys Gln Lys Lys 
            100                 105                 110         


Ala Ala Leu Ser Ala Ser Glu Gly Glu Glu Val Pro Gln Asp Lys Ala 
        115                 120                 125             


Pro Ser His Val Pro Phe Leu Leu Ile Gly Gly Gly Xaa Ala Ala Phe 
    130                 135                 140                 


Ala Ala Ala Arg Ser Ile Arg Ala Arg Asp Pro Gly Ala Arg Val Leu 
145                 150                 155                 160 


Ile Val Ser Glu Asp Pro Glu Leu Pro Tyr Met Arg Pro Pro Leu Ser 
                165                 170                 175     


Lys Glu Leu Trp Phe Ser Asp Asp Pro Asn Val Xaa Lys Xaa Leu Arg 
            180                 185                 190         


Phe Lys Gln Trp Asn Gly Lys Glu Arg Ser Ile Tyr Phe Gln Pro Pro 
        195                 200                 205             


Ser Phe Tyr Val Ser Ala Gln Asp Leu Pro His Ile Glu Asn Gly Gly 
    210                 215                 220                 


Val Ala Val Leu Xaa Gly Lys Lys Val Val Gln Leu Asp Val Arg Asp 
225                 230                 235                 240 


Asn Met Val Lys Leu Asn Asp Gly Ser Gln Ile Xaa Tyr Glu Lys Cys 
                245                 250                 255     


Leu Ile Ala Xaa Gly Gly Xaa Pro Arg Ser Leu Ser Ala Ile Asp Arg 
            260                 265                 270         


Ala Gly Ala Glu Val Lys Ser Arg Xaa Xaa Leu Phe Arg Lys Ile Gly 
        275                 280                 285             


Asp Phe Arg Ser Leu Glu Lys Ile Ser Arg Glu Val Lys Ser Ile Xaa 
    290                 295                 300                 


Ile Ile Gly Gly Gly Phe Leu Gly Ser Glu Leu Ala Cys Ala Leu Gly 
305                 310                 315                 320 


Arg Lys Asp Ile 
                


<210> 2039
<211> 613
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<400> 2039
Met Phe Arg Cys Gly Gly Leu Ala Ala Gly Ala Leu Lys Gln Lys Leu 
1               5                   10                  15      


Val Pro Leu Val Arg Xaa Val Cys Val Arg Ser Pro Arg Gln Arg Asn 
            20                  25                  30          


Arg Leu Pro Gly Asn Leu Phe Gln Arg Trp His Val Pro Leu Glu Leu 
        35                  40                  45              


Gln Met Xaa Arg Gln Met Ala Ser Ser Gly Ala Ser Gly Gly Lys Ile 
    50                  55                  60                  


Asp Asn Ser Val Leu Val Leu Ile Val Gly Leu Ser Xaa Val Gly Ala 
65                  70                  75                  80  


Gly Ala Tyr Ala Tyr Lys Xaa Met Lys Glu Asp Glu Lys Arg Tyr Asn 
                85                  90                  95      


Glu Arg Ile Ser Gly Leu Gly Leu Xaa Pro Glu Gln Lys Gln Lys Lys 
            100                 105                 110         


Ala Ala Leu Ser Ala Ser Glu Gly Glu Glu Val Pro Gln Asp Lys Ala 
        115                 120                 125             


Pro Ser His Val Pro Phe Leu Leu Ile Gly Gly Gly Xaa Ala Ala Phe 
    130                 135                 140                 


Ala Ala Ala Arg Ser Ile Arg Ala Arg Asp Pro Gly Ala Arg Val Leu 
145                 150                 155                 160 


Ile Val Ser Glu Asp Pro Glu Leu Pro Tyr Met Arg Pro Pro Leu Ser 
                165                 170                 175     


Lys Glu Leu Trp Phe Ser Asp Asp Pro Asn Val Xaa Lys Xaa Leu Arg 
            180                 185                 190         


Phe Lys Gln Trp Asn Gly Lys Glu Arg Ser Ile Tyr Phe Gln Pro Pro 
        195                 200                 205             


Ser Phe Tyr Val Ser Ala Gln Asp Leu Pro His Ile Glu Asn Gly Gly 
    210                 215                 220                 


Val Ala Val Leu Xaa Gly Lys Lys Val Val Gln Leu Asp Val Arg Asp 
225                 230                 235                 240 


Asn Met Val Lys Leu Asn Asp Gly Ser Gln Ile Xaa Tyr Glu Lys Cys 
                245                 250                 255     


Leu Ile Ala Xaa Gly Gly Xaa Pro Arg Ser Leu Ser Ala Ile Asp Arg 
            260                 265                 270         


Ala Gly Ala Glu Val Lys Ser Arg Xaa Xaa Leu Phe Arg Lys Ile Gly 
        275                 280                 285             


Asp Phe Arg Ser Leu Glu Lys Ile Ser Arg Glu Val Lys Ser Ile Xaa 
    290                 295                 300                 


Ile Ile Gly Gly Gly Phe Leu Gly Ser Glu Leu Ala Cys Ala Leu Gly 
305                 310                 315                 320 


Arg Lys Ala Arg Ala Leu Gly Xaa Glu Val Ile Gln Leu Phe Pro Glu 
                325                 330                 335     


Lys Gly Asn Met Gly Lys Ile Leu Pro Glu Tyr Leu Ser Asn Trp Xaa 
            340                 345                 350         


Met Glu Lys Val Arg Arg Glu Gly Val Lys Val Met Pro Asn Ala Ile 
        355                 360                 365             


Val Gln Ser Val Gly Val Ser Ser Gly Lys Leu Leu Ile Lys Leu Lys 
    370                 375                 380                 


Asp Gly Arg Lys Val Glu Xaa Asp His Ile Val Ala Ala Val Gly Leu 
385                 390                 395                 400 


Glu Pro Asn Val Glu Leu Ala Lys Xaa Gly Gly Leu Glu Ile Asp Ser 
                405                 410                 415     


Asp Phe Gly Gly Phe Arg Val Asn Ala Glu Leu Gln Ala Arg Ser Asn 
            420                 425                 430         


Ile Trp Val Ala Gly Asp Ala Ala Cys Phe Tyr Asp Ile Lys Leu Gly 
        435                 440                 445             


Arg Arg Arg Val Glu His His Asp His Ala Val Val Ser Gly Arg Leu 
    450                 455                 460                 


Ala Gly Glu Asn Met Xaa Gly Ala Ala Lys Pro Tyr Trp His Gln Ser 
465                 470                 475                 480 


Met Phe Trp Ser Asp Leu Gly Pro Asp Val Gly Tyr Glu Ala Ile Gly 
                485                 490                 495     


Leu Val Asp Ser Ser Leu Pro Xaa Val Gly Val Phe Ala Lys Ala Xaa 
            500                 505                 510         


Ala Gln Asp Asn Pro Lys Ser Ala Xaa Glu Gln Ser Gly Xaa Gly Ile 
        515                 520                 525             


Arg Ser Glu Ser Glu Xaa Glu Ser Glu Ala Ser Glu Ile Xaa Ile Pro 
    530                 535                 540                 


Pro Ser Xaa Pro Ala Val Pro Gln Ala Pro Val Gln Gly Glu Asp Tyr 
545                 550                 555                 560 


Gly Lys Gly Val Ile Phe Tyr Leu Arg Asp Lys Val Val Val Gly Ile 
                565                 570                 575     


Val Leu Trp Asn Ile Phe Asn Arg Met Pro Ile Ala Arg Lys Ile Ile 
            580                 585                 590         


Lys Asp Gly Glu Gln His Glu Asp Leu Asn Glu Val Ala Lys Leu Phe 
        595                 600                 605             


Asn Ile His Glu Asp 
    610             


<210> 2040
<211> 89
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 2040
Met Phe Arg Cys Gly Gly Leu Ala Ala Gly Ala Leu Lys Gln Lys Leu 
1               5                   10                  15      


Val Pro Leu Val Arg Xaa Val Cys Val Arg Ser Pro Arg Gln Arg Asn 
            20                  25                  30          


Arg Leu Pro Gly Asn Leu Phe Gln Arg Trp His Val Pro Leu Glu Leu 
        35                  40                  45              


Gln Met Xaa Arg Gln Met Ala Ser Ser Gly Ala Ser Gly Gly Lys Ile 
    50                  55                  60                  


Asp Asn Ser Val Leu Val Leu Ile Val Gly Leu Ser Xaa Val Gly Ala 
65                  70                  75                  80  


Gly Ala Tyr Leu Cys Ser Leu Ile Xaa 
                85                  


<210> 2041
<211> 609
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<400> 2041
Met Phe Arg Cys Gly Gly Leu Ala Ala Gly Ala Leu Lys Gln Lys Leu 
1               5                   10                  15      


Val Pro Leu Val Arg Xaa Val Cys Val Arg Ser Pro Arg Gln Arg Asn 
            20                  25                  30          


Arg Leu Pro Val Val Gln Ser His His Leu Gly Ser Pro Ser Arg Ser 
        35                  40                  45              


Leu Ala Ser Xaa Gly Ala Ser Gly Lys Asp Gly Ser Asn Leu Val Tyr 
    50                  55                  60                  


Phe Leu Ile Val Gly Ala Xaa Val Xaa Gly Ala Gly Val Tyr Tyr Ala 
65                  70                  75                  80  


Tyr Lys Xaa Met Lys Glu Asp Glu Lys Arg Tyr Asn Glu Arg Ile Ser 
                85                  90                  95      


Gly Leu Gly Leu Xaa Pro Glu Gln Lys Gln Lys Lys Ala Ala Leu Ser 
            100                 105                 110         


Ala Ser Glu Gly Glu Glu Val Pro Gln Asp Lys Ala Pro Ser His Val 
        115                 120                 125             


Pro Phe Leu Leu Ile Gly Gly Gly Xaa Ala Ala Phe Ala Ala Ala Arg 
    130                 135                 140                 


Ser Ile Arg Ala Arg Asp Pro Gly Ala Arg Val Leu Ile Val Ser Glu 
145                 150                 155                 160 


Asp Pro Glu Leu Pro Tyr Met Arg Pro Pro Leu Ser Lys Glu Leu Trp 
                165                 170                 175     


Phe Ser Asp Asp Pro Asn Val Xaa Lys Xaa Leu Arg Phe Lys Gln Trp 
            180                 185                 190         


Asn Gly Lys Glu Arg Ser Ile Tyr Phe Gln Pro Pro Ser Phe Tyr Val 
        195                 200                 205             


Ser Ala Gln Asp Leu Pro His Ile Glu Asn Gly Gly Val Ala Val Leu 
    210                 215                 220                 


Xaa Gly Lys Lys Val Val Gln Leu Asp Val Arg Asp Asn Met Val Lys 
225                 230                 235                 240 


Leu Asn Asp Gly Ser Gln Ile Xaa Tyr Glu Lys Cys Leu Ile Ala Xaa 
                245                 250                 255     


Gly Gly Xaa Pro Arg Ser Leu Ser Ala Ile Asp Arg Ala Gly Ala Glu 
            260                 265                 270         


Val Lys Ser Arg Xaa Xaa Leu Phe Arg Lys Ile Gly Asp Phe Arg Ser 
        275                 280                 285             


Leu Glu Lys Ile Ser Arg Glu Val Lys Ser Ile Xaa Ile Ile Gly Gly 
    290                 295                 300                 


Gly Phe Leu Gly Ser Glu Leu Ala Cys Ala Leu Gly Arg Lys Ala Arg 
305                 310                 315                 320 


Ala Leu Gly Xaa Glu Val Ile Gln Leu Phe Pro Glu Lys Gly Asn Met 
                325                 330                 335     


Gly Lys Ile Leu Pro Glu Tyr Leu Ser Asn Trp Xaa Met Glu Lys Val 
            340                 345                 350         


Arg Arg Glu Gly Val Lys Val Met Pro Asn Ala Ile Val Gln Ser Val 
        355                 360                 365             


Gly Val Ser Ser Gly Lys Leu Leu Ile Lys Leu Lys Asp Gly Arg Lys 
    370                 375                 380                 


Val Glu Xaa Asp His Ile Val Ala Ala Val Gly Leu Glu Pro Asn Val 
385                 390                 395                 400 


Glu Leu Ala Lys Xaa Gly Gly Leu Glu Ile Asp Ser Asp Phe Gly Gly 
                405                 410                 415     


Phe Arg Val Asn Ala Glu Leu Gln Ala Arg Ser Asn Ile Trp Val Ala 
            420                 425                 430         


Gly Asp Ala Ala Cys Phe Tyr Asp Ile Lys Leu Gly Arg Arg Arg Val 
        435                 440                 445             


Glu His His Asp His Ala Val Val Ser Gly Arg Leu Ala Gly Glu Asn 
    450                 455                 460                 


Met Xaa Gly Ala Ala Lys Pro Tyr Trp His Gln Ser Met Phe Trp Ser 
465                 470                 475                 480 


Asp Leu Gly Pro Asp Val Gly Tyr Glu Ala Ile Gly Leu Val Asp Ser 
                485                 490                 495     


Ser Leu Pro Xaa Val Gly Val Phe Ala Lys Ala Xaa Ala Gln Asp Asn 
            500                 505                 510         


Pro Lys Ser Ala Xaa Glu Gln Ser Gly Xaa Gly Ile Arg Ser Glu Ser 
        515                 520                 525             


Glu Xaa Glu Ser Glu Ala Ser Glu Ile Xaa Ile Pro Pro Ser Xaa Pro 
    530                 535                 540                 


Ala Val Pro Gln Ala Pro Val Gln Gly Glu Asp Tyr Gly Lys Gly Val 
545                 550                 555                 560 


Ile Phe Tyr Leu Arg Asp Lys Val Val Val Gly Ile Val Leu Trp Asn 
                565                 570                 575     


Ile Phe Asn Arg Met Pro Ile Ala Arg Lys Ile Ile Lys Asp Gly Glu 
            580                 585                 590         


Gln His Glu Asp Leu Asn Glu Val Ala Lys Leu Phe Asn Ile His Glu 
        595                 600                 605             


Asp 
    


<210> 2042
<211> 274
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<400> 2042
Met Gly Lys Ile Leu Pro Glu Tyr Leu Ser Asn Trp Xaa Met Glu Lys 
1               5                   10                  15      


Val Arg Arg Glu Gly Val Lys Val Met Pro Asn Ala Ile Val Gln Ser 
            20                  25                  30          


Val Gly Val Ser Ser Gly Lys Leu Leu Ile Lys Leu Lys Asp Gly Arg 
        35                  40                  45              


Lys Val Glu Xaa Asp His Ile Val Ala Ala Val Gly Leu Glu Pro Asn 
    50                  55                  60                  


Val Glu Leu Ala Lys Xaa Gly Gly Leu Glu Ile Asp Ser Asp Phe Gly 
65                  70                  75                  80  


Gly Phe Arg Val Asn Ala Glu Leu Gln Ala Arg Ser Asn Ile Trp Val 
                85                  90                  95      


Ala Gly Asp Ala Ala Cys Phe Tyr Asp Ile Lys Leu Gly Arg Arg Arg 
            100                 105                 110         


Val Glu His His Asp His Ala Val Val Ser Gly Arg Leu Ala Gly Glu 
        115                 120                 125             


Asn Met Xaa Gly Ala Ala Lys Pro Tyr Trp His Gln Ser Met Phe Trp 
    130                 135                 140                 


Ser Asp Leu Gly Pro Asp Val Gly Tyr Glu Ala Ile Gly Leu Val Asp 
145                 150                 155                 160 


Ser Ser Leu Pro Xaa Val Gly Val Phe Ala Lys Ala Xaa Ala Gln Asp 
                165                 170                 175     


Asn Pro Lys Ser Ala Xaa Glu Gln Ser Gly Xaa Gly Ile Arg Ser Glu 
            180                 185                 190         


Ser Glu Xaa Glu Ser Glu Ala Ser Glu Ile Xaa Ile Pro Pro Ser Xaa 
        195                 200                 205             


Pro Ala Val Pro Gln Ala Pro Val Gln Gly Glu Asp Tyr Gly Lys Gly 
    210                 215                 220                 


Val Ile Phe Tyr Leu Arg Asp Lys Val Val Val Gly Ile Val Leu Trp 
225                 230                 235                 240 


Asn Ile Phe Asn Arg Met Pro Ile Ala Arg Lys Ile Ile Lys Asp Gly 
                245                 250                 255     


Glu Gln His Glu Asp Leu Asn Glu Val Ala Lys Leu Phe Asn Ile His 
            260                 265                 270         


Glu Asp 
        


<210> 2043
<211> 343
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<400> 2043
Met Glu Ser Lys Tyr Lys Glu Ile Leu Leu Leu Xaa Gly Leu Asp Asn 
1               5                   10                  15      


Ile Xaa Asp Glu Glu Leu Asp Arg Phe Lys Phe Phe Leu Ser Asp Glu 
            20                  25                  30          


Phe Asn Ile Ala Xaa Gly Lys Leu His Xaa Ala Asn Arg Ile Gln Val 
        35                  40                  45              


Ala Xaa Leu Met Ile Gln Asn Ala Gly Ala Val Ser Ala Val Met Lys 
    50                  55                  60                  


Xaa Ile Arg Ile Phe Gln Lys Leu Asn Tyr Met Leu Leu Ala Lys Arg 
65                  70                  75                  80  


Leu Gln Glu Glu Lys Glu Lys Val Asp Lys Gln Tyr Lys Ser Val Xaa 
                85                  90                  95      


Lys Pro Lys Pro Leu Ser Gln Ala Glu Met Ser Pro Ala Ala Ser Ala 
            100                 105                 110         


Ala Ile Arg Asn Asp Val Ala Lys Gln Arg Ala Ala Pro Lys Val Ser 
        115                 120                 125             


Pro His Val Lys Pro Glu Gln Lys Gln Met Val Ala Gln Gln Glu Ser 
    130                 135                 140                 


Ile Arg Glu Gly Phe Gln Lys Arg Cys Leu Pro Val Met Val Leu Lys 
145                 150                 155                 160 


Ala Lys Lys Pro Phe Xaa Phe Glu Xaa Gln Glu Gly Lys Gln Glu Met 
                165                 170                 175     


Phe His Ala Xaa Val Ala Xaa Glu Lys Glu Phe Phe Phe Val Lys Val 
            180                 185                 190         


Phe Asn Xaa Leu Leu Lys Asp Lys Phe Ile Pro Lys Arg Ile Ile Ile 
        195                 200                 205             


Ile Ala Arg Tyr Tyr Arg His Ser Gly Phe Leu Glu Val Asn Ser Ala 
    210                 215                 220                 


Ser Arg Val Leu Asp Ala Glu Ser Asp Gln Lys Val Asn Val Pro Leu 
225                 230                 235                 240 


Asn Ile Ile Arg Lys Ala Gly Glu Xaa Pro Lys Ile Asn Xaa Leu Gln 
                245                 250                 255     


Xaa Gln Pro Leu Gly Xaa Ile Val Asn Gly Leu Phe Val Val Gln Lys 
            260                 265                 270         


Val Xaa Glu Lys Lys Lys Asn Ile Leu Phe Asp Leu Ser Asp Asn Xaa 
        275                 280                 285             


Gly Lys Met Glu Val Leu Gly Val Arg Asn Glu Asp Xaa Met Lys Cys 
    290                 295                 300                 


Lys Glu Gly Asp Lys Val Arg Leu Xaa Phe Phe Xaa Leu Ser Lys Asn 
305                 310                 315                 320 


Gly Glu Lys Leu Gln Leu Xaa Ser Gly Val His Ser Xaa Ile Lys Val 
                325                 330                 335     


Ile Lys Ala Lys Lys Lys Xaa 
            340             


<210> 2044
<211> 167
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<400> 2044
Met Val Ala Gln Gln Glu Ser Ile Arg Glu Gly Phe Gln Lys Arg Cys 
1               5                   10                  15      


Leu Pro Val Met Val Leu Lys Ala Lys Lys Pro Phe Xaa Phe Glu Xaa 
            20                  25                  30          


Gln Glu Gly Lys Gln Glu Met Phe His Ala Xaa Val Ala Xaa Glu Lys 
        35                  40                  45              


Glu Phe Phe Phe Val Lys Val Phe Asn Xaa Leu Leu Lys Asp Lys Phe 
    50                  55                  60                  


Ile Pro Lys Arg Ile Ile Ile Ile Ala Arg Tyr Tyr Arg His Ser Gly 
65                  70                  75                  80  


Phe Leu Glu Val Asn Ser Ala Ser Arg Val Leu Asp Ala Glu Ser Asp 
                85                  90                  95      


Gln Lys Val Asn Val Pro Leu Asn Ile Ile Arg Lys Ala Gly Glu Xaa 
            100                 105                 110         


Pro Lys Ile Asn Xaa Leu Gln Xaa Gln Pro Leu Gly Xaa Ile Val Asn 
        115                 120                 125             


Gly Leu Phe Val Val Gln Lys Val Xaa Glu Lys Lys Lys Asn Ile Leu 
    130                 135                 140                 


Phe Asp Leu Ser Asp Asn Xaa Gly Lys Met Glu Val Leu Gly Val Arg 
145                 150                 155                 160 


Asn Glu Asp Xaa Met Lys Cys 
                165         


<210> 2045
<211> 150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 2045
Met Ala Asn Asn Asp Ala Val Leu Lys Arg Leu Glu Gln Lys Gly Ala 
1               5                   10                  15      


Glu Ala Asp Gln Ile Ile Glu Tyr Leu Lys Gln Gln Val Ser Leu Leu 
            20                  25                  30          


Lys Glu Lys Ala Ile Leu Gln Ala Xaa Leu Arg Glu Glu Lys Lys Leu 
        35                  40                  45              


Arg Val Glu Asn Ala Lys Leu Lys Lys Glu Ile Glu Glu Leu Lys Gln 
    50                  55                  60                  


Glu Leu Ile Gln Ala Glu Ile Gln Asn Gly Val Lys Gln Ile Pro Phe 
65                  70                  75                  80  


Pro Ser Gly Xaa Pro Leu His Ala Asn Ser Met Val Ser Glu Asn Val 
                85                  90                  95      


Ile Gln Ser Xaa Ala Val Xaa Xaa Val Ser Ser Gly Xaa Lys Glu Gln 
            100                 105                 110         


Ile Lys Gly Gly Xaa Gly Asp Glu Lys Lys Ala Lys Glu Lys Ile Glu 
        115                 120                 125             


Lys Lys Gly Glu Lys Lys Glu Lys Lys Gln Gln Ser Ile Ala Gly Ser 
    130                 135                 140                 


Ala Asp Ser Lys Pro Ile 
145                 150 


<210> 2046
<211> 312
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<400> 2046
Met Ala Asn Asn Asp Ala Val Leu Lys Arg Leu Glu Gln Lys Gly Ala 
1               5                   10                  15      


Glu Ala Asp Gln Ile Ile Glu Tyr Leu Lys Gln Gln Val Ser Leu Leu 
            20                  25                  30          


Lys Glu Lys Ala Ile Leu Gln Ala Xaa Leu Arg Glu Glu Lys Lys Leu 
        35                  40                  45              


Arg Val Glu Asn Ala Lys Leu Lys Lys Glu Ile Glu Glu Leu Lys Gln 
    50                  55                  60                  


Glu Leu Ile Gln Ala Glu Ile Gln Asn Gly Val Lys Gln Ile Pro Phe 
65                  70                  75                  80  


Pro Ser Gly Xaa Pro Leu His Ala Asn Ser Met Val Ser Glu Asn Val 
                85                  90                  95      


Ile Gln Ser Xaa Ala Val Xaa Xaa Val Ser Ser Gly Xaa Lys Glu Gln 
            100                 105                 110         


Ile Lys Gly Gly Xaa Gly Asp Glu Lys Lys Ala Lys Glu Lys Ile Glu 
        115                 120                 125             


Lys Lys Gly Glu Lys Lys Glu Lys Lys Gln Gln Ser Ile Ala Gly Ser 
    130                 135                 140                 


Ala Asp Ser Lys Pro Ile Asp Val Ser Arg Leu Asp Leu Arg Ile Gly 
145                 150                 155                 160 


Cys Ile Ile Xaa Ala Arg Lys His Pro Asp Ala Asp Ser Leu Tyr Val 
                165                 170                 175     


Glu Glu Val Asp Val Gly Glu Ile Ala Pro Arg Xaa Val Val Ser Gly 
            180                 185                 190         


Leu Val Asn His Val Pro Leu Glu Gln Met Gln Asn Arg Met Val Ile 
        195                 200                 205             


Leu Leu Cys Asn Leu Lys Pro Ala Lys Met Arg Gly Val Leu Ser Gln 
    210                 215                 220                 


Ala Met Val Met Cys Ala Ser Ser Pro Glu Lys Ile Glu Ile Leu Ala 
225                 230                 235                 240 


Pro Pro Asn Gly Ser Val Pro Gly Asp Arg Ile Xaa Phe Asp Ala Phe 
                245                 250                 255     


Pro Gly Glu Pro Asp Lys Glu Leu Asn Pro Lys Lys Lys Ile Trp Glu 
            260                 265                 270         


Gln Ile Gln Pro Asp Leu His Xaa Asn Asp Glu Cys Val Ala Xaa Tyr 
        275                 280                 285             


Lys Gly Val Pro Phe Glu Val Lys Gly Lys Gly Val Cys Arg Ala Gln 
    290                 295                 300                 


Xaa Met Ser Asn Ser Gly Ile Lys 
305                 310         


<210> 2047
<211> 336
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<400> 2047
Met Leu Pro Ala Val Ala Val Ser Glu Pro Val Val Leu Arg Phe Met 
1               5                   10                  15      


Ile Phe Cys Arg Leu Leu Ala Lys Met Ala Asn Asn Asp Ala Val Leu 
            20                  25                  30          


Lys Arg Leu Glu Gln Lys Gly Ala Glu Ala Asp Gln Ile Ile Glu Tyr 
        35                  40                  45              


Leu Lys Gln Gln Val Ser Leu Leu Lys Glu Lys Ala Ile Leu Gln Ala 
    50                  55                  60                  


Xaa Leu Arg Glu Glu Lys Lys Leu Arg Val Glu Asn Ala Lys Leu Lys 
65                  70                  75                  80  


Lys Glu Ile Glu Glu Leu Lys Gln Glu Leu Ile Gln Ala Glu Ile Gln 
                85                  90                  95      


Asn Gly Val Lys Gln Ile Pro Phe Pro Ser Gly Xaa Pro Leu His Ala 
            100                 105                 110         


Asn Ser Met Val Ser Glu Asn Val Ile Gln Ser Xaa Ala Val Xaa Xaa 
        115                 120                 125             


Val Ser Ser Gly Xaa Lys Glu Gln Ile Lys Gly Gly Xaa Gly Asp Glu 
    130                 135                 140                 


Lys Lys Ala Lys Glu Lys Ile Glu Lys Lys Gly Glu Lys Lys Glu Lys 
145                 150                 155                 160 


Lys Gln Gln Ser Ile Ala Gly Ser Ala Asp Ser Lys Pro Ile Asp Val 
                165                 170                 175     


Ser Arg Leu Asp Leu Arg Ile Gly Cys Ile Ile Xaa Ala Arg Lys His 
            180                 185                 190         


Pro Asp Ala Asp Ser Leu Tyr Val Glu Glu Val Asp Val Gly Glu Ile 
        195                 200                 205             


Ala Pro Arg Xaa Val Val Ser Gly Leu Val Asn His Val Pro Leu Glu 
    210                 215                 220                 


Gln Met Gln Asn Arg Met Val Ile Leu Leu Cys Asn Leu Lys Pro Ala 
225                 230                 235                 240 


Lys Met Arg Gly Val Leu Ser Gln Ala Met Val Met Cys Ala Ser Ser 
                245                 250                 255     


Pro Glu Lys Ile Glu Ile Leu Ala Pro Pro Asn Gly Ser Val Pro Gly 
            260                 265                 270         


Asp Arg Ile Xaa Phe Asp Ala Phe Pro Gly Glu Pro Asp Lys Glu Leu 
        275                 280                 285             


Asn Pro Lys Lys Lys Ile Trp Glu Gln Ile Gln Pro Asp Leu His Xaa 
    290                 295                 300                 


Asn Asp Glu Cys Val Ala Xaa Tyr Lys Gly Val Pro Phe Glu Val Lys 
305                 310                 315                 320 


Gly Lys Gly Val Cys Arg Ala Gln Xaa Met Ser Asn Ser Gly Ile Lys 
                325                 330                 335     


<210> 2048
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 2048
Gly Gln Arg His Cys Cys Gly Val Ala Gln Met Arg Glu His Ser Ser 
1               5                   10                  15      


Leu Gly His Ala Asp Leu Asp Ala Leu Gln Gln Asn Pro Gln Pro Leu 
            20                  25                  30          


Ile Phe His Met Glu Met Leu Lys Val Glu Ser Pro Gly Xaa Tyr Gln 
        35                  40                  45              


Gln Asp Pro Trp Ala Met Xaa Asp Glu Glu Lys Ala Lys Ala Val Pro 
    50                  55                  60                  


Leu Ile His Gln Glu Gly Asn Arg Leu Tyr Arg Glu Gly His Val Lys 
65                  70                  75                  80  


Glu Ala Ala Ala Lys Tyr Tyr Asp Ala Ile Ala Cys Leu Lys Asn Leu 
                85                  90                  95      


Gln Met Lys Glu Gln Pro Gly Ser Pro Glu Trp Ile Gln Leu Asp Gln 
            100                 105                 110         


Gln Ile Xaa Pro Leu Leu Leu Asn Tyr Cys Gln Cys Lys Leu Val Val 
        115                 120                 125             


Glu Glu Tyr Tyr Glu Val Leu Asp His Cys Ser Ser Ile Leu Asn Lys 
    130                 135                 140                 


Tyr Asp Gly Glu His Arg Ala Leu Gly Cys Arg Gly Leu Arg Val Val 
145                 150                 155                 160 


Arg Glu Trp Pro Phe Ser Cys His Cys Trp Gly Gln Asp Leu Ala Phe 
                165                 170                 175     


His Asn Pro His Ser Glu Leu Pro Arg Gly Pro Asp 
            180                 185             


<210> 2049
<211> 330
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<400> 2049
Met Ala Asp Ile Ile Ala Arg Leu Arg Glu Asp Gly Ile Gln Lys Arg 
1               5                   10                  15      


Val Ile Gln Glu Gly Arg Gly Glu Leu Pro Asp Phe Gln Asp Gly Xaa 
            20                  25                  30          


Lys Ala Xaa Phe His Tyr Arg Xaa Leu His Ser Asp Asp Glu Gly Xaa 
        35                  40                  45              


Val Leu Asp Asp Ser Arg Ala Arg Gly Lys Pro Met Glu Leu Ile Ile 
    50                  55                  60                  


Gly Lys Lys Phe Lys Leu Pro Val Trp Glu Xaa Ile Val Cys Xaa Met 
65                  70                  75                  80  


Arg Glu Gly Glu Ile Ala Gln Phe Leu Cys Asp Ile Lys His Val Val 
                85                  90                  95      


Leu Tyr Pro Leu Val Ala Lys Ser Leu Arg Asn Ile Ala Val Gly Lys 
            100                 105                 110         


Asp Pro Leu Glu Gly Gln Arg His Cys Cys Gly Val Ala Gln Met Arg 
        115                 120                 125             


Glu His Ser Ser Leu Gly His Ala Asp Leu Asp Ala Leu Gln Gln Asn 
    130                 135                 140                 


Pro Gln Pro Leu Ile Phe His Met Glu Met Leu Lys Val Glu Ser Pro 
145                 150                 155                 160 


Gly Xaa Tyr Gln Gln Asp Pro Trp Ala Met Xaa Asp Glu Glu Lys Ala 
                165                 170                 175     


Lys Ala Val Pro Leu Ile His Gln Glu Gly Asn Arg Leu Tyr Arg Glu 
            180                 185                 190         


Gly His Val Lys Glu Ala Ala Ala Lys Tyr Tyr Asp Ala Ile Ala Cys 
        195                 200                 205             


Leu Lys Asn Leu Gln Met Lys Glu Gln Pro Gly Ser Pro Glu Trp Ile 
    210                 215                 220                 


Gln Leu Asp Gln Gln Ile Xaa Pro Leu Leu Leu Asn Tyr Cys Gln Cys 
225                 230                 235                 240 


Lys Leu Val Val Glu Glu Tyr Tyr Glu Val Leu Asp His Cys Ser Ser 
                245                 250                 255     


Ile Leu Asn Lys Tyr Asp Asp Asn Val Lys Ala Tyr Phe Lys Arg Gly 
            260                 265                 270         


Lys Ala His Ala Ala Val Trp Asn Ala Gln Glu Ala Gln Ala Asp Phe 
        275                 280                 285             


Ala Lys Val Leu Glu Leu Asp Pro Ala Leu Ala Pro Val Val Ser Arg 
    290                 295                 300                 


Glu Leu Arg Ala Leu Glu Ala Arg Ile Arg Gln Lys Asp Glu Glu Asp 
305                 310                 315                 320 


Lys Ala Arg Phe Arg Gly Ile Phe Ser His 
                325                 330 


<210> 2050
<211> 232
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<400> 2050
Met Ala Asp Ile Ile Ala Arg Leu Arg Glu Asp Gly Ile Gln Lys Arg 
1               5                   10                  15      


Val Ile Gln Glu Gly Arg Gly Glu Leu Pro Asp Phe Gln Asp Gly Xaa 
            20                  25                  30          


Lys Ala Xaa Phe His Tyr Arg Xaa Leu His Ser Asp Asp Glu Gly Xaa 
        35                  40                  45              


Val Leu Asp Asp Ser Arg Ala Arg Gly Lys Pro Met Glu Leu Ile Ile 
    50                  55                  60                  


Gly Lys Lys Phe Lys Leu Pro Val Trp Glu Xaa Ile Val Cys Xaa Met 
65                  70                  75                  80  


Arg Glu Gly Glu Ile Ala Gln Phe Leu Cys Asp Ile Lys Val Glu Ser 
                85                  90                  95      


Pro Gly Xaa Tyr Gln Gln Asp Pro Trp Ala Met Xaa Asp Glu Glu Lys 
            100                 105                 110         


Ala Lys Ala Val Pro Leu Ile His Gln Glu Gly Asn Arg Leu Tyr Arg 
        115                 120                 125             


Glu Gly His Val Lys Glu Ala Ala Ala Lys Tyr Tyr Asp Ala Ile Ala 
    130                 135                 140                 


Cys Leu Lys Asn Leu Gln Met Lys Glu Gln Pro Gly Ser Pro Glu Trp 
145                 150                 155                 160 


Ile Gln Leu Asp Gln Gln Ile Xaa Pro Leu Leu Leu Asn Tyr Cys Gln 
                165                 170                 175     


Cys Lys Leu Val Val Glu Glu Tyr Tyr Glu Val Leu Asp His Cys Ser 
            180                 185                 190         


Ser Ile Leu Asn Lys Tyr Asp Asp Asn Val Lys Ala Tyr Phe Lys Arg 
        195                 200                 205             


Gly Lys Ala His Ala Ala Val Trp Asn Ala Gln Glu Ala Gln Ala Asp 
    210                 215                 220                 


Phe Ala Lys Val Leu Glu Leu Asp 
225                 230         


<210> 2051
<211> 545
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<400> 2051
Met Ala Xaa Asp Ala Ala Leu Arg Arg Leu Leu Arg Leu His Arg Xaa 
1               5                   10                  15      


Glu Ile Ala Val Ala Val Asp Ser Ala Phe Pro Leu Leu His Ala Leu 
            20                  25                  30          


Ala Asp His Asp Val Val Pro Glu Asp Lys Phe Gln Glu Xaa Leu His 
        35                  40                  45              


Leu Lys Glu Lys Glu Gly Cys Pro Gln Ala Phe His Ala Leu Leu Ser 
    50                  55                  60                  


Trp Leu Leu Xaa Gln Asp Ser Xaa Ala Ile Leu Asp Phe Trp Arg Val 
65                  70                  75                  80  


Leu Phe Lys Asp Tyr Asn Leu Glu Arg Tyr Gly Arg Leu Gln Pro Ile 
                85                  90                  95      


Leu Asp Ser Phe Pro Lys Asp Val Asp Leu Ser Gln Pro Arg Lys Gly 
            100                 105                 110         


Arg Lys Pro Pro Ala Val Pro Lys Ala Leu Val Pro Pro Pro Arg Leu 
        115                 120                 125             


Pro Xaa Lys Arg Lys Ala Ser Glu Glu Ala Arg Ala Ala Ala Pro Ala 
    130                 135                 140                 


Ala Leu Xaa Pro Arg Gly Xaa Ala Ser Pro Gly Ser Gln Leu Lys Ala 
145                 150                 155                 160 


Lys Pro Pro Lys Lys Pro Glu Ser Ser Ala Glu Gln Gln Arg Leu Pro 
                165                 170                 175     


Leu Gly Asn Gly Ile Gln Xaa Met Ser Ala Ser Val Gln Arg Ala Val 
            180                 185                 190         


Ala Met Ser Ser Gly Asp Val Pro Gly Ala Arg Gly Ala Val Glu Gly 
        195                 200                 205             


Ile Leu Ile Gln Gln Val Phe Glu Ser Gly Gly Ser Lys Lys Cys Ile 
    210                 215                 220                 


Gln Val Gly Gly Glu Phe Tyr Xaa Pro Ser Lys Phe Glu Asp Ser Gly 
225                 230                 235                 240 


Ser Gly Lys Asn Lys Ala Arg Ser Ser Ser Gly Pro Lys Pro Leu Val 
                245                 250                 255     


Arg Ala Lys Gly Ala Gln Gly Ala Ala Pro Gly Gly Gly Glu Ala Arg 
            260                 265                 270         


Leu Gly Gln Gln Gly Ser Val Pro Ala Pro Leu Ala Leu Pro Ser Asp 
        275                 280                 285             


Pro Gln Leu His Gln Lys Asn Glu Asp Glu Cys Ala Val Cys Arg Asp 
    290                 295                 300                 


Gly Gly Glu Leu Ile Cys Cys Asp Gly Cys Pro Arg Ala Phe His Leu 
305                 310                 315                 320 


Ala Cys Leu Ser Pro Pro Leu Arg Glu Ile Pro Ser Gly Xaa Trp Arg 
                325                 330                 335     


Cys Ser Ser Cys Leu Gln Ala Xaa Val Gln Glu Val Gln Pro Arg Ala 
            340                 345                 350         


Glu Glu Pro Arg Pro Gln Glu Pro Pro Val Glu Xaa Pro Leu Pro Pro 
        355                 360                 365             


Gly Leu Arg Ser Ala Gly Glu Glu Val Arg Gly Pro Pro Gly Glu Pro 
    370                 375                 380                 


Leu Ala Gly Met Asp Xaa Xaa Leu Val Tyr Lys His Leu Pro Ala Pro 
385                 390                 395                 400 


Pro Ser Ala Ala Pro Leu Pro Gly Leu Asp Ser Ser Ala Leu His Pro 
                405                 410                 415     


Leu Leu Cys Val Gly Pro Glu Gly Gln Gln Asn Leu Ala Pro Gly Ala 
            420                 425                 430         


Arg Cys Gly Val Cys Gly Asp Gly Xaa Asp Val Leu Arg Cys Xaa His 
        435                 440                 445             


Cys Ala Ala Ala Phe His Trp Arg Cys His Phe Pro Ala Gly Xaa Ser 
    450                 455                 460                 


Arg Pro Gly Xaa Gly Leu Arg Cys Arg Ser Cys Ser Gly Asp Val Xaa 
465                 470                 475                 480 


Pro Ala Pro Val Glu Gly Val Leu Ala Pro Ser Pro Ala Arg Leu Ala 
                485                 490                 495     


Pro Gly Pro Ala Lys Asp Asp Xaa Ala Ser His Glu Pro Ala Leu His 
            500                 505                 510         


Arg Asp Asp Leu Glu Ser Leu Leu Ser Glu His Xaa Phe Asp Gly Ile 
        515                 520                 525             


Leu Gln Trp Ala Ile Gln Ser Met Ala Arg Pro Ala Ala Pro Phe Pro 
    530                 535                 540                 


Ser 
545 


<210> 2052
<211> 538
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<400> 2052
Met Glu Arg Leu Gly Glu Lys Ala Ser Arg Leu Leu Glu Lys Phe Gly 
1               5                   10                  15      


Arg Arg Lys Gly Glu Ser Ser Arg Ser Gly Ser Asp Gly Xaa Pro Gly 
            20                  25                  30          


Pro Gly Lys Gly Arg Leu Ser Gly Leu Gly Gly Pro Arg Lys Ser Gly 
        35                  40                  45              


Pro Arg Gly Ala Xaa Gly Gly Pro Gly Asp Glu Pro Leu Glu Pro Ala 
    50                  55                  60                  


Arg Glu Gln Gly Ser Leu Asp Ala Glu Arg Asn Gln Arg Gly Ser Phe 
65                  70                  75                  80  


Glu Ala Pro Arg Tyr Glu Gly Ser Phe Pro Ala Gly Pro Pro Pro Xaa 
                85                  90                  95      


Arg Ala Leu Pro Leu Pro Gln Ser Leu Pro Pro Asp Phe Arg Leu Glu 
            100                 105                 110         


Pro Xaa Ala Pro Ala Leu Ser Pro Arg Ser Ser Phe Ala Ser Ser Ser 
        115                 120                 125             


Ala Ser Asp Ala Ser Lys Pro Ser Ser Pro Arg Gly Ser Leu Leu Leu 
    130                 135                 140                 


Asp Gly Ala Gly Ala Gly Gly Ala Gly Gly Ser Arg Pro Cys Ser Asn 
145                 150                 155                 160 


Arg Xaa Ser Gly Ile Ser Met Gly Tyr Asp Gln Arg His Gly Ser Pro 
                165                 170                 175     


Leu Pro Ala Gly Pro Cys Leu Phe Gly Pro Pro Leu Ala Gly Ala Pro 
            180                 185                 190         


Ala Gly Tyr Ser Pro Gly Gly Val Pro Ser Ala Tyr Pro Glu Leu His 
        195                 200                 205             


Ala Ala Leu Asp Arg Leu Tyr Ala Gln Arg Pro Ala Gly Phe Gly Cys 
    210                 215                 220                 


Gln Glu Ser Arg His Ser Tyr Pro Pro Ala Leu Gly Ser Pro Gly Ala 
225                 230                 235                 240 


Leu Ala Gly Ala Gly Val Gly Ala Ala Gly Pro Leu Glu Arg Arg Gly 
                245                 250                 255     


Ala Gln Pro Gly Arg His Ser Val Xaa Gly Tyr Gly Asp Cys Ala Val 
            260                 265                 270         


Gly Ala Arg Tyr Gln Asp Glu Leu Xaa Ala Leu Leu Arg Leu Xaa Val 
        275                 280                 285             


Gly Xaa Gly Gly Arg Glu Ala Gly Ala Arg Gly Glu Pro Ser Gly Ile 
    290                 295                 300                 


Glu Pro Ser Gly Leu Glu Glu Pro Pro Gly Pro Phe Val Pro Glu Ala 
305                 310                 315                 320 


Ala Arg Ala Arg Met Arg Glu Pro Glu Ala Arg Glu Asp Tyr Phe Gly 
                325                 330                 335     


Xaa Cys Ile Lys Cys Asn Lys Gly Ile Tyr Gly Gln Ser Asn Ala Cys 
            340                 345                 350         


Gln Ala Leu Asp Ser Leu Tyr His Xaa Gln Cys Phe Val Cys Cys Ser 
        355                 360                 365             


Cys Gly Arg Xaa Leu Arg Cys Lys Ala Phe Tyr Ser Val Asn Gly Ser 
    370                 375                 380                 


Val Tyr Cys Glu Glu Asp Tyr Leu Phe Ser Gly Phe Gln Glu Ala Ala 
385                 390                 395                 400 


Glu Lys Cys Cys Val Cys Gly His Leu Ile Leu Glu Lys Ile Leu Gln 
                405                 410                 415     


Ala Met Gly Lys Ser Tyr His Pro Gly Cys Phe Arg Cys Ile Val Cys 
            420                 425                 430         


Asn Lys Cys Leu Asp Gly Ile Pro Phe Xaa Val Asp Phe Ser Asn Gln 
        435                 440                 445             


Val Tyr Cys Val Xaa Asp Tyr His Lys Asn Tyr Ala Pro Lys Cys Ala 
    450                 455                 460                 


Ala Cys Gly Gln Pro Ile Leu Pro Ser Glu Gly Cys Glu Asp Ile Val 
465                 470                 475                 480 


Arg Val Ile Ser Met Asp Arg Asp Tyr His Phe Glu Cys Tyr His Cys 
                485                 490                 495     


Glu Asp Cys Arg Met Gln Leu Ser Asp Glu Glu Gly Cys Cys Cys Phe 
            500                 505                 510         


Pro Leu Asp Gly His Leu Leu Cys His Gly Cys His Met Gln Arg Leu 
        515                 520                 525             


Asn Ala Arg Gln Pro Pro Ala Asn Tyr Ile 
    530                 535             


<210> 2053
<211> 65
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<400> 2053
Met Gly Lys Ser Tyr His Pro Gly Cys Phe Arg Cys Ile Val Cys Asn 
1               5                   10                  15      


Lys Cys Leu Asp Gly Ile Pro Phe Xaa Val Asp Phe Ser Asn Gln Val 
            20                  25                  30          


Tyr Cys Val Xaa Asp Tyr His Lys Asn Tyr Ala Pro Lys Cys Ala Ala 
        35                  40                  45              


Cys Gly Gln Pro Ile Leu Pro Ser Glu Gly Cys Glu Asp Ile Val Arg 
    50                  55                  60                  


Val 
65  


<210> 2054
<211> 80
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<400> 2054
Met Gly Lys Ser Tyr His Pro Gly Cys Phe Arg Cys Ile Val Cys Asn 
1               5                   10                  15      


Lys Cys Leu Asp Gly Ile Pro Phe Xaa Val Asp Phe Ser Asn Gln Val 
            20                  25                  30          


Tyr Cys Val Xaa Asp Tyr His Lys Asn Tyr Ala Pro Lys Cys Ala Ala 
        35                  40                  45              


Cys Gly Gln Pro Ile Leu Pro Ser Glu Gly Cys Glu Asp Ile Val Arg 
    50                  55                  60                  


Val Ile Ser Met Asp Arg Asp Tyr His Phe Glu Cys Tyr His Cys Glu 
65                  70                  75                  80  


<210> 2055
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<400> 2055
Met Gly Lys Ser Tyr His Pro Gly Cys Phe Arg Cys Ile Val Cys Asn 
1               5                   10                  15      


Lys Cys Leu Asp Gly Ile Pro Phe Xaa Val Asp Phe Ser Asn Gln Val 
            20                  25                  30          


Tyr Cys Val Xaa Asp Tyr His Lys Asn Tyr Ala Pro Lys Cys Ala Ala 
        35                  40                  45              


Cys Gly Gln Pro Ile Leu Pro Ser Glu Gly Cys Glu Asp Ile Val Arg 
    50                  55                  60                  


Val Ile Ser Met Asp Arg Asp Tyr His Phe Glu Cys Tyr His Cys Glu 
65                  70                  75                  80  


Asp Cys Arg Met Gln Leu Ser Asp Glu Glu Gly Cys Cys Cys Phe Pro 
                85                  90                  95      


Leu Asp Gly His Leu Leu Cys His Gly Cys His Met Gln Arg Leu Asn 
            100                 105                 110         


Ala Arg Gln Pro Pro Ala Asn Tyr Ile 
        115                 120     


<210> 2056
<211> 143
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<400> 2056
Xaa Arg His Ser Tyr Pro Pro Ala Leu Gly Ser Pro Gly Ala Leu Ala 
1               5                   10                  15      


Gly Ala Gly Val Gly Ala Ala Gly Pro Leu Glu Arg Arg Gly Ala Gln 
            20                  25                  30          


Pro Gly Arg His Ser Val Xaa Gly Tyr Gly Asp Cys Ala Val Gly Ala 
        35                  40                  45              


Arg Tyr Gln Asp Glu Leu Xaa Ala Leu Leu Arg Leu Xaa Val Gly Xaa 
    50                  55                  60                  


Gly Gly Arg Glu Ala Gly Ala Arg Gly Glu Pro Ser Gly Ile Glu Pro 
65                  70                  75                  80  


Ser Gly Leu Glu Glu Pro Pro Gly Pro Phe Val Pro Glu Ala Ala Arg 
                85                  90                  95      


Ala Arg Met Arg Glu Pro Glu Ala Arg Glu Asp Tyr Phe Gly Ile Met 
            100                 105                 110         


Leu Xaa Trp Ser Pro Leu His Gly Ala Leu Cys Gln Ala Arg Ser Phe 
        115                 120                 125             


Ser Pro Ser Leu Glu Val Cys Ser Gly Glu Lys Ser Phe Tyr Asn 
    130                 135                 140             


<210> 2057
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<400> 2057
Met Ser Val Gln Tyr Pro Arg Arg Arg Ala Xaa Ala Gly Glu Lys Pro 
1               5                   10                  15      


Gly Asn Glu Pro Glu Glu Val Lys Leu Gln Asn Ala Ser Lys Gln Ile 
            20                  25                  30          


Val Gln Asn Ala Ile Leu Gln Ala Val Gln Gln Val Ser Gln Glu Ser 
        35                  40                  45              


Gln Arg Arg Glu Glu Arg Ile Ser Asp Asn Arg Asp His Ile Gln Leu 
    50                  55                  60                  


Gly Val Gly Glu Leu Xaa Lys Lys His Glu Lys Lys 
65                  70                  75      


<210> 2058
<211> 69
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<400> 2058
Met Val Phe Ala Pro Gly Glu Lys Pro Gly Asn Glu Pro Glu Glu Val 
1               5                   10                  15      


Lys Leu Gln Asn Ala Ser Lys Gln Ile Val Gln Asn Ala Ile Leu Gln 
            20                  25                  30          


Ala Val Gln Gln Val Ser Gln Glu Ser Gln Arg Arg Glu Glu Arg Ile 
        35                  40                  45              


Ser Asp Asn Arg Asp His Ile Gln Leu Gly Val Gly Glu Leu Xaa Lys 
    50                  55                  60                  


Lys His Glu Lys Lys 
65                  


<210> 2059
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 2059
Ala Glu Lys Arg Ser Ser Gly Glu Arg Ala Arg Glu Xaa Gly Gly Ala 
1               5                   10                  15      


Glu Gly Xaa Gly Asp Ala Val Leu Gly Glu Lys Val Leu Glu Glu Ala 
            20                  25                  30          


Leu Leu Ser Arg Glu His Val Leu Glu Leu Glu Asn Ser Lys Gly Pro 
        35                  40                  45              


Ser Leu Ala Ser Leu Glu Gly Glu Glu Asp Lys Gly Lys Ser Ser Ser 
    50                  55                  60                  


Ser Gln Val Val Gly Pro Val Gln Glu Glu Glu Tyr Val Ala Glu Lys 
65                  70                  75                  80  


Leu Pro Ser Arg Phe Ile Glu Ser Ala His Xaa Glu Leu Ala Lys Asp 
                85                  90                  95      


Asp Ala Ala Pro Ala Pro Pro Val Ala Asp Ala Lys Ala Gln Asp Arg 
            100                 105                 110         


Gly Val Glu Gly Glu Leu Gly Asn Glu Glu Ser Leu Asp Arg Asn Glu 
        115                 120                 125             


Glu Asp Leu Gly Ala Glu Asp Gly Trp Xaa Met Asp Ala Glu Ala Asp 
    130                 135                 140                 


His Ser Gly Gly Ser Asp Arg Asn Ser Met Asp Ser Val Asp Ser Cys 
145                 150                 155                 160 


Cys Ser Leu Lys Lys Xaa Glu Ser Phe Gln Asn Ala Gln Ala Gly Ser 
                165                 170                 175     


Asn Pro Lys Lys Val Asp Leu Ile Ile Trp Glu Ile Glu Val Pro Lys 
            180                 185                 190         


His Leu Val Gly Arg Leu Ile Gly Lys Gln Gly Arg 
        195                 200                 


<210> 2060
<211> 360
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<400> 2060
Leu Pro Leu Pro Gly Leu Pro Ala Glu Gly Ser Pro Pro Pro Lys Xaa 
1               5                   10                  15      


Tyr Val Ser Cys Leu Lys Ser Leu Leu Ser Ser Pro Xaa Lys Asp Ser 
            20                  25                  30          


Lys Pro Asn Ile Ser Ala His His Ile Ser Leu Ala Ser Cys Leu Ala 
        35                  40                  45              


Leu Xaa Xaa Pro Ser Glu Glu Leu Pro Asp Arg Ala Gly Ile Leu Val 
    50                  55                  60                  


Glu Asp Ala Xaa Cys Val Xaa Cys Met Ser Asp Ser Ser Gln Ser Val 
65                  70                  75                  80  


Pro Leu Val Ala Ser Pro Gly His Cys Ser Asp Ser Phe Ser Xaa Ser 
                85                  90                  95      


Gly Leu Glu Asp Ser Cys Xaa Glu Xaa Ser Ser Ser Pro Arg Asp Lys 
            100                 105                 110         


Ala Ile Xaa Pro Pro Leu Pro Glu Ser Xaa Val Pro Phe Ser Asn Gly 
        115                 120                 125             


Val Leu Lys Gly Glu Leu Ser Asp Leu Gly Ala Glu Asp Gly Trp Xaa 
    130                 135                 140                 


Met Asp Ala Glu Ala Asp His Ser Gly Gly Ser Asp Arg Asn Ser Met 
145                 150                 155                 160 


Asp Ser Val Asp Ser Cys Cys Ser Leu Lys Lys Xaa Glu Ser Phe Gln 
                165                 170                 175     


Asn Ala Gln Ala Gly Ser Asn Pro Lys Lys Val Asp Leu Ile Ile Trp 
            180                 185                 190         


Glu Ile Glu Val Pro Lys His Leu Val Gly Arg Leu Ile Gly Lys Gln 
        195                 200                 205             


Gly Arg Tyr Val Ser Phe Leu Lys Gln Xaa Ser Gly Ala Lys Ile Tyr 
    210                 215                 220                 


Ile Ser Xaa Leu Pro Tyr Xaa Gln Ser Val Gln Ile Cys His Ile Glu 
225                 230                 235                 240 


Gly Ser Gln His His Val Asp Lys Ala Leu Asn Leu Ile Gly Lys Lys 
                245                 250                 255     


Phe Lys Glu Leu Asn Leu Xaa Asn Ile Tyr Ala Pro Pro Leu Pro Ser 
            260                 265                 270         


Leu Ala Leu Pro Ser Leu Pro Met Xaa Ser Trp Leu Met Leu Pro Asp 
        275                 280                 285             


Gly Ile Xaa Val Glu Val Ile Val Val Asn Gln Val Asn Ala Gly His 
    290                 295                 300                 


Leu Phe Val Gln Gln His Xaa His Pro Xaa Phe His Ala Leu Arg Ser 
305                 310                 315                 320 


Leu Asp Gln Gln Met Tyr Leu Cys Tyr Ser Gln Pro Gly Ile Pro Xaa 
                325                 330                 335     


Leu Pro Xaa Pro Val Glu Ser Leu Xaa Leu Ser Pro Cys Arg Phe Arg 
            340                 345                 350         


Glu Gln Lys Ser Phe Trp Xaa Val 
        355                 360 


<210> 2061
<211> 7
<212> PRT
<213> Homo sapiens

<400> 2061
Met Ala Ile Gln Phe Arg Ser 
1               5           


<210> 2062
<211> 8
<212> PRT
<213> Homo sapiens

<400> 2062
Met Ala Ile Gln Phe Arg Ser Leu 
1               5               


<210> 2063
<211> 47
<212> PRT
<213> Homo sapiens

<400> 2063
Met Ala Ile Gln Phe Arg Ser Leu Phe Pro Leu Ala Leu Pro Gly Met 
1               5                   10                  15      


Leu Ala Leu Leu Gly Trp Trp Trp Phe Phe Ser Arg Lys Lys Gly His 
            20                  25                  30          


Val Ser Ser His Asp Glu Gln Gln Val Glu Ala Gly Ala Val Gln 
        35                  40                  45          


<210> 2064
<211> 83
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<400> 2064
Met Ala Ile Gln Phe Arg Ser Leu Phe Pro Leu Ala Leu Pro Gly Met 
1               5                   10                  15      


Leu Ala Leu Leu Gly Trp Trp Trp Phe Phe Ser Arg Lys Lys Gly His 
            20                  25                  30          


Val Ser Ser His Asp Glu Gln Gln Val Glu Ala Gly Ala Val Gln Leu 
        35                  40                  45              


Arg Ala Asp Pro Ala Ile Lys Glu Pro Leu Pro Val Glu Asp Val Cys 
    50                  55                  60                  


Pro Lys Val Val Ser Xaa Pro Pro Ser Val Xaa Glu Pro Pro Glu Lys 
65                  70                  75                  80  


Glu Leu Ser 
            


<210> 2065
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<400> 2065
Met Ala Ile Gln Phe Arg Ser Leu Phe Pro Leu Ala Leu Pro Gly Met 
1               5                   10                  15      


Leu Ala Leu Leu Gly Trp Trp Trp Phe Phe Ser Arg Lys Lys Gly His 
            20                  25                  30          


Val Ser Ser His Asp Glu Gln Gln Val Glu Ala Gly Ala Val Gln Leu 
        35                  40                  45              


Arg Ala Asp Pro Ala Ile Lys Glu Pro Leu Pro Val Glu Asp Val Cys 
    50                  55                  60                  


Pro Lys Val Val Ser Xaa Pro Pro Ser Val Xaa Glu Pro Pro Glu Lys 
65                  70                  75                  80  


Glu Leu Ser Xaa Val Ser Lys Leu Pro Ala Glu Pro Pro Ala Leu 
                85                  90                  95  


<210> 2066
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 2066
Met Ala Ile Gln Phe Arg Ser Leu Phe Pro Leu Ala Leu Pro Gly Met 
1               5                   10                  15      


Leu Ala Leu Leu Gly Trp Trp Trp Phe Phe Ser Arg Lys Lys Gly His 
            20                  25                  30          


Val Ser Ser His Asp Glu Gln Gln Val Glu Ala Gly Ala Val Gln Leu 
        35                  40                  45              


Arg Ala Asp Pro Ala Ile Lys Glu Pro Leu Pro Val Glu Asp Val Cys 
    50                  55                  60                  


Pro Lys Val Val Ser Xaa Pro Pro Ser Val Xaa Glu Pro Pro Glu Lys 
65                  70                  75                  80  


Glu Leu Ser Xaa Val Ser Lys Leu Pro Ala Glu Pro Pro Ala Leu Leu 
                85                  90                  95      


Gln Xaa His Pro Pro Cys Arg Arg Ser Glu Ser Ser Gly Ile Leu Pro 
            100                 105                 110         


Asn Xaa Xaa Asp Met Arg Leu Arg Pro Gly Xaa Arg Arg Asp Asp Ser 
        115                 120                 125             


Xaa Lys Leu Glu Leu Ala Leu Xaa Gly 
    130                 135         


<210> 2067
<211> 183
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 2067
Met Ala Ile Gln Phe Arg Ser Leu Phe Pro Leu Ala Leu Pro Gly Met 
1               5                   10                  15      


Leu Ala Leu Leu Gly Trp Trp Trp Phe Phe Ser Arg Lys Lys Gly His 
            20                  25                  30          


Val Ser Ser His Asp Glu Gln Gln Val Glu Ala Gly Ala Val Gln Leu 
        35                  40                  45              


Arg Ala Asp Pro Ala Ile Lys Glu Pro Leu Pro Val Glu Asp Val Cys 
    50                  55                  60                  


Pro Lys Val Val Ser Xaa Pro Pro Ser Val Xaa Glu Pro Pro Glu Lys 
65                  70                  75                  80  


Glu Leu Ser Xaa Val Ser Lys Leu Pro Ala Glu Pro Pro Ala Leu Leu 
                85                  90                  95      


Gln Xaa His Pro Pro Cys Arg Arg Ser Glu Ser Ser Gly Ile Leu Pro 
            100                 105                 110         


Asn Xaa Xaa Asp Met Arg Leu Arg Pro Gly Xaa Arg Arg Asp Asp Ser 
        115                 120                 125             


Xaa Lys Leu Glu Leu Ala Leu Xaa Gly Gly Glu Ala Lys Ser Ile Pro 
    130                 135                 140                 


Leu Glu Cys Pro Leu Ser Ser Pro Lys Gly Val Leu Phe Ser Ser Lys 
145                 150                 155                 160 


Ser Ala Glu Val Cys Lys Gln Asp Ser Pro Phe Ser Arg Val Pro Arg 
                165                 170                 175     


Lys Val Gln Pro Gly Tyr Pro 
            180             


<210> 2068
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 2068
Met Ala Ile Gln Phe Arg Ser Leu Phe Pro Leu Ala Leu Pro Gly Met 
1               5                   10                  15      


Leu Ala Leu Leu Gly Trp Trp Trp Phe Phe Ser Arg Lys Lys Gly His 
            20                  25                  30          


Val Ser Ser His Asp Glu Gln Gln Val Glu Ala Gly Ala Val Gln Leu 
        35                  40                  45              


Arg Ala Asp Pro Ala Ile Lys Glu Pro Leu Pro Val Glu Asp Val Cys 
    50                  55                  60                  


Pro Lys Val Val Ser Xaa Pro Pro Ser Val Xaa Glu Pro Pro Glu Lys 
65                  70                  75                  80  


Glu Leu Ser Xaa Val Ser Lys Leu Pro Ala Glu Pro Pro Ala Leu Leu 
                85                  90                  95      


Gln Xaa His Pro Pro Cys Arg Arg Ser Glu Ser Ser Gly Ile Leu Pro 
            100                 105                 110         


Asn Xaa Xaa Asp Met Arg Leu Arg Pro Gly Xaa Arg Arg Asp Asp Ser 
        115                 120                 125             


Xaa Lys Leu Glu Leu Ala Leu Xaa Gly Gly Glu Ala Lys Ser Ile Pro 
    130                 135                 140                 


Leu Glu Cys Pro Leu Ser Ser Pro Lys Gly Val Leu Phe Ser Ser Lys 
145                 150                 155                 160 


Ser Ala Glu Val Cys Lys Gln Asp Ser Pro Phe Ser Arg Val Pro Arg 
                165                 170                 175     


Lys Val Gln Pro Gly Tyr Pro Val Val Pro 
            180                 185     


<210> 2069
<211> 593
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<400> 2069
Met Ala Ile Gln Phe Arg Ser Leu Phe Pro Leu Ala Leu Pro Gly Met 
1               5                   10                  15      


Leu Ala Leu Leu Gly Trp Trp Trp Phe Phe Ser Arg Lys Lys Gly His 
            20                  25                  30          


Val Ser Ser His Asp Glu Gln Gln Val Glu Ala Gly Ala Val Gln Leu 
        35                  40                  45              


Arg Ala Asp Pro Ala Ile Lys Glu Pro Leu Pro Val Glu Asp Val Cys 
    50                  55                  60                  


Pro Lys Val Val Ser Xaa Pro Pro Ser Val Xaa Glu Pro Pro Glu Lys 
65                  70                  75                  80  


Glu Leu Ser Xaa Val Ser Lys Leu Pro Ala Glu Pro Pro Ala Leu Leu 
                85                  90                  95      


Gln Xaa His Pro Pro Cys Arg Arg Ser Glu Ser Ser Gly Ile Leu Pro 
            100                 105                 110         


Asn Xaa Xaa Asp Met Arg Leu Arg Pro Gly Xaa Arg Arg Asp Asp Ser 
        115                 120                 125             


Xaa Lys Leu Glu Leu Ala Leu Xaa Gly Gly Glu Ala Lys Ser Ile Pro 
    130                 135                 140                 


Leu Glu Cys Pro Leu Ser Ser Pro Lys Gly Val Leu Phe Ser Ser Lys 
145                 150                 155                 160 


Ser Ala Glu Val Cys Lys Gln Asp Ser Pro Phe Ser Arg Val Pro Arg 
                165                 170                 175     


Lys Val Gln Pro Gly Tyr Pro Val Val Pro Ala Glu Lys Arg Ser Ser 
            180                 185                 190         


Gly Glu Arg Ala Arg Glu Xaa Gly Gly Ala Glu Gly Xaa Gly Asp Ala 
        195                 200                 205             


Val Leu Gly Glu Lys Val Leu Glu Glu Ala Leu Leu Ser Arg Glu His 
    210                 215                 220                 


Val Leu Glu Leu Glu Asn Ser Lys Gly Pro Ser Leu Ala Ser Leu Glu 
225                 230                 235                 240 


Gly Glu Glu Asp Lys Gly Lys Ser Ser Ser Ser Gln Val Val Gly Pro 
                245                 250                 255     


Val Gln Glu Glu Glu Tyr Val Ala Glu Lys Leu Pro Ser Arg Phe Ile 
            260                 265                 270         


Glu Ser Ala His Xaa Glu Leu Ala Lys Asp Asp Ala Ala Pro Ala Pro 
        275                 280                 285             


Pro Val Ala Asp Ala Lys Ala Gln Asp Arg Gly Val Glu Gly Glu Leu 
    290                 295                 300                 


Gly Asn Glu Glu Ser Leu Asp Arg Asn Glu Glu Gly Leu Asp Arg Asn 
305                 310                 315                 320 


Glu Glu Gly Leu Asp Arg Asn Glu Glu Ser Leu Asp Arg Asn Glu Glu 
                325                 330                 335     


Gly Leu Asp Arg Asn Glu Glu Ile Lys Arg Ala Ala Phe Gln Ile Ile 
            340                 345                 350         


Ser Gln Val Ile Ser Glu Ala Xaa Glu Gln Val Leu Ala Xaa Xaa Val 
        355                 360                 365             


Gly Lys Val Ala Gly Arg Val Cys Gln Ala Ser Gln Leu Gln Gly Gln 
    370                 375                 380                 


Lys Glu Glu Ser Cys Val Pro Val His Gln Lys Xaa Val Leu Gly Pro 
385                 390                 395                 400 


Asp Xaa Ala Glu Pro Ala Xaa Ala Glu Ala Ala Val Ala Pro Pro Asp 
                405                 410                 415     


Ala Gly Leu Pro Leu Pro Gly Leu Pro Ala Glu Gly Ser Pro Pro Pro 
            420                 425                 430         


Lys Xaa Tyr Val Ser Cys Leu Lys Ser Leu Leu Ser Ser Pro Xaa Lys 
        435                 440                 445             


Asp Ser Lys Pro Asn Ile Ser Ala His His Ile Ser Leu Ala Ser Cys 
    450                 455                 460                 


Leu Ala Leu Xaa Xaa Pro Ser Glu Glu Leu Pro Asp Arg Ala Gly Ile 
465                 470                 475                 480 


Leu Val Glu Asp Ala Xaa Cys Val Xaa Cys Met Ser Asp Ser Ser Gln 
                485                 490                 495     


Ser Val Pro Leu Val Ala Ser Pro Gly His Cys Ser Asp Ser Phe Ser 
            500                 505                 510         


Xaa Ser Gly Leu Glu Asp Ser Cys Xaa Glu Xaa Ser Ser Ser Pro Arg 
        515                 520                 525             


Asp Lys Ala Ile Xaa Pro Pro Leu Pro Glu Ser Xaa Val Pro Phe Ser 
    530                 535                 540                 


Asn Gly Val Leu Lys Gly Glu Leu Ser Asp Leu Gly Ala Glu Asp Gly 
545                 550                 555                 560 


Trp Xaa Met Asp Ala Glu Ala Asp His Ser Gly Val Ala Ala Pro Pro 
                565                 570                 575     


Pro Gly Lys Arg Gly Xaa Leu Ile Xaa Arg Cys Pro Gly Phe Phe Glu 
            580                 585                 590         


Cys 
    


<210> 2070
<211> 903
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<400> 2070
Met Ala Ile Gln Phe Arg Ser Leu Phe Pro Leu Ala Leu Pro Gly Met 
1               5                   10                  15      


Leu Ala Leu Leu Gly Trp Trp Trp Phe Phe Ser Arg Lys Lys Gly His 
            20                  25                  30          


Val Ser Ser His Asp Glu Gln Gln Val Glu Ala Gly Ala Val Gln Leu 
        35                  40                  45              


Arg Ala Asp Pro Ala Ile Lys Glu Pro Leu Pro Val Glu Asp Val Cys 
    50                  55                  60                  


Pro Lys Val Val Ser Xaa Pro Pro Ser Val Xaa Glu Pro Pro Glu Lys 
65                  70                  75                  80  


Glu Leu Ser Xaa Val Ser Lys Leu Pro Ala Glu Pro Pro Ala Leu Leu 
                85                  90                  95      


Gln Xaa His Pro Pro Cys Arg Arg Ser Glu Ser Ser Gly Ile Leu Pro 
            100                 105                 110         


Asn Xaa Xaa Asp Met Arg Leu Arg Pro Gly Xaa Arg Arg Asp Asp Ser 
        115                 120                 125             


Xaa Lys Leu Glu Leu Ala Leu Xaa Gly Gly Glu Ala Lys Ser Ile Pro 
    130                 135                 140                 


Leu Glu Cys Pro Leu Ser Ser Pro Lys Gly Val Leu Phe Ser Ser Lys 
145                 150                 155                 160 


Ser Ala Glu Val Cys Lys Gln Asp Ser Pro Phe Ser Arg Val Pro Arg 
                165                 170                 175     


Lys Val Gln Pro Gly Tyr Pro Val Val Pro Ala Glu Lys Arg Ser Ser 
            180                 185                 190         


Gly Glu Arg Ala Arg Glu Xaa Gly Gly Ala Glu Gly Xaa Gly Asp Ala 
        195                 200                 205             


Val Leu Gly Glu Lys Val Leu Glu Glu Ala Leu Leu Ser Arg Glu His 
    210                 215                 220                 


Val Leu Glu Leu Glu Asn Ser Lys Gly Pro Ser Leu Ala Ser Leu Glu 
225                 230                 235                 240 


Gly Glu Glu Asp Lys Gly Lys Ser Ser Ser Ser Gln Val Val Gly Pro 
                245                 250                 255     


Val Gln Glu Glu Glu Tyr Val Ala Glu Lys Leu Pro Ser Arg Phe Ile 
            260                 265                 270         


Glu Ser Ala His Xaa Glu Leu Ala Lys Asp Asp Ala Ala Pro Ala Pro 
        275                 280                 285             


Pro Val Ala Asp Ala Lys Ala Gln Asp Arg Gly Val Glu Gly Glu Leu 
    290                 295                 300                 


Gly Asn Glu Glu Ser Leu Asp Arg Asn Glu Glu Gly Leu Asp Arg Asn 
305                 310                 315                 320 


Glu Glu Gly Leu Asp Arg Asn Glu Glu Ser Leu Asp Arg Asn Glu Glu 
                325                 330                 335     


Gly Leu Asp Arg Asn Glu Glu Ile Lys Arg Ala Ala Phe Gln Ile Ile 
            340                 345                 350         


Ser Gln Val Ile Ser Glu Ala Xaa Glu Gln Val Leu Ala Xaa Xaa Val 
        355                 360                 365             


Gly Lys Val Ala Gly Arg Val Cys Gln Ala Ser Gln Leu Gln Gly Gln 
    370                 375                 380                 


Lys Glu Glu Ser Cys Val Pro Val His Gln Lys Xaa Val Leu Gly Pro 
385                 390                 395                 400 


Asp Xaa Ala Glu Pro Ala Xaa Ala Glu Ala Ala Val Ala Pro Pro Asp 
                405                 410                 415     


Ala Gly Leu Pro Leu Pro Gly Leu Pro Ala Glu Gly Ser Pro Pro Pro 
            420                 425                 430         


Lys Xaa Tyr Val Ser Cys Leu Lys Ser Leu Leu Ser Ser Pro Xaa Lys 
        435                 440                 445             


Asp Ser Lys Pro Asn Ile Ser Ala His His Ile Ser Leu Ala Ser Cys 
    450                 455                 460                 


Leu Ala Leu Xaa Xaa Pro Ser Glu Glu Leu Pro Asp Arg Ala Gly Ile 
465                 470                 475                 480 


Leu Val Glu Asp Ala Xaa Cys Val Xaa Cys Met Ser Asp Ser Ser Gln 
                485                 490                 495     


Ser Val Pro Leu Val Ala Ser Pro Gly His Cys Ser Asp Ser Phe Ser 
            500                 505                 510         


Xaa Ser Gly Leu Glu Asp Ser Cys Xaa Glu Xaa Ser Ser Ser Pro Arg 
        515                 520                 525             


Asp Lys Ala Ile Xaa Pro Pro Leu Pro Glu Ser Xaa Val Pro Phe Ser 
    530                 535                 540                 


Asn Gly Val Leu Lys Gly Glu Leu Ser Asp Leu Gly Ala Glu Asp Gly 
545                 550                 555                 560 


Trp Xaa Met Asp Ala Glu Ala Asp His Ser Gly Gly Ser Asp Arg Asn 
                565                 570                 575     


Ser Met Asp Ser Val Asp Ser Cys Cys Ser Leu Lys Lys Xaa Glu Ser 
            580                 585                 590         


Phe Gln Asn Ala Gln Ala Gly Ser Asn Pro Lys Lys Val Asp Leu Ile 
        595                 600                 605             


Ile Trp Glu Ile Glu Val Pro Lys His Leu Val Gly Arg Leu Ile Gly 
    610                 615                 620                 


Lys Gln Gly Arg Tyr Val Ser Phe Leu Lys Gln Xaa Ser Gly Ala Lys 
625                 630                 635                 640 


Ile Tyr Ile Ser Xaa Leu Pro Tyr Xaa Gln Ser Val Gln Ile Cys His 
                645                 650                 655     


Ile Glu Gly Ser Gln His His Val Asp Lys Ala Leu Asn Leu Ile Gly 
            660                 665                 670         


Lys Lys Phe Lys Glu Leu Asn Leu Xaa Asn Ile Tyr Ala Pro Pro Leu 
        675                 680                 685             


Pro Ser Leu Ala Leu Pro Ser Leu Pro Met Xaa Ser Trp Leu Met Leu 
    690                 695                 700                 


Pro Asp Gly Ile Xaa Val Glu Val Ile Val Val Asn Gln Val Asn Ala 
705                 710                 715                 720 


Gly His Leu Phe Val Gln Gln His Xaa His Pro Xaa Phe His Ala Leu 
                725                 730                 735     


Arg Ser Leu Asp Gln Gln Met Tyr Leu Cys Tyr Ser Gln Pro Gly Ile 
            740                 745                 750         


Pro Xaa Leu Pro Xaa Pro Val Glu Ile Xaa Val Ile Cys Ala Ala Pro 
        755                 760                 765             


Gly Ala Asp Gly Ala Trp Trp Arg Ala Gln Val Val Ala Ser Tyr Glu 
    770                 775                 780                 


Glu Xaa Asn Glu Val Glu Ile Arg Tyr Val Asp Tyr Gly Gly Tyr Lys 
785                 790                 795                 800 


Arg Val Lys Val Asp Val Leu Arg Gln Ile Arg Ser Asp Phe Val Xaa 
                805                 810                 815     


Leu Pro Phe Gln Gly Ala Glu Val Leu Leu Asp Ser Val Met Pro Leu 
            820                 825                 830         


Ser Asp Asp Asp Gln Phe Ser Pro Glu Ala Asp Ala Ala Met Ser Glu 
        835                 840                 845             


Met Xaa Gly Asn Xaa Ala Leu Leu Ala Gln Val Xaa Ser Tyr Ser Pro 
    850                 855                 860                 


Xaa Gly Leu Pro Leu Ile Gln Leu Trp Ser Val Val Gly Asp Glu Val 
865                 870                 875                 880 


Val Leu Ile Asn Arg Ser Leu Val Glu Arg Gly Leu Ala Gln Trp Val 
                885                 890                 895     


Asp Ser Tyr Tyr Xaa Ser Leu 
            900             


<210> 2071
<211> 179
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 2071
Val Ile Val Val Asn Gln Val Asn Ala Gly His Leu Phe Val Gln Gln 
1               5                   10                  15      


His Xaa His Pro Xaa Phe His Ala Leu Arg Ser Leu Asp Gln Gln Met 
            20                  25                  30          


Tyr Leu Cys Tyr Ser Gln Pro Gly Ile Pro Xaa Leu Pro Xaa Pro Val 
        35                  40                  45              


Glu Ile Xaa Val Ile Cys Ala Ala Pro Gly Ala Asp Gly Ala Trp Trp 
    50                  55                  60                  


Arg Ala Gln Val Val Ala Ser Tyr Glu Glu Xaa Asn Glu Val Glu Ile 
65                  70                  75                  80  


Arg Tyr Val Asp Tyr Gly Gly Tyr Lys Arg Val Lys Val Asp Val Leu 
                85                  90                  95      


Arg Gln Ile Arg Ser Asp Phe Val Xaa Leu Pro Phe Gln Gly Ala Glu 
            100                 105                 110         


Val Leu Leu Asp Ser Val Met Pro Leu Ser Asp Asp Asp Gln Phe Ser 
        115                 120                 125             


Pro Glu Ala Asp Ala Ala Met Ser Glu Met Xaa Gly Asn Xaa Ala Leu 
    130                 135                 140                 


Leu Ala Gln Val Xaa Ser Tyr Ser Pro Xaa Gly Leu Pro Leu Ile Gln 
145                 150                 155                 160 


Leu Trp Ser Val Val Gly Asp Glu Xaa Gly Phe Ser Ile Val Gln Phe 
                165                 170                 175     


Lys Asn Lys 
            


<210> 2072
<211> 139
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 2072
Xaa Gly Ala Asp Gly Ala Trp Trp Arg Ala Gln Val Val Ala Ser Tyr 
1               5                   10                  15      


Glu Glu Xaa Asn Glu Val Glu Ile Arg Tyr Val Asp Tyr Gly Gly Tyr 
            20                  25                  30          


Lys Arg Val Lys Val Asp Val Leu Arg Gln Ile Arg Ser Asp Phe Val 
        35                  40                  45              


Xaa Leu Pro Phe Gln Gly Ala Glu Val Leu Leu Asp Ser Val Met Pro 
    50                  55                  60                  


Leu Ser Asp Asp Asp Gln Phe Ser Pro Glu Ala Asp Ala Ala Met Ser 
65                  70                  75                  80  


Glu Met Xaa Gly Asn Xaa Ala Leu Leu Ala Gln Val Xaa Ser Tyr Ser 
                85                  90                  95      


Pro Xaa Gly Leu Pro Leu Ile Gln Leu Trp Ser Val Val Gly Asp Glu 
            100                 105                 110         


Val Val Leu Ile Asn Arg Ser Leu Val Glu Arg Gly Leu Ala Gln Leu 
        115                 120                 125             


Ala Ser Ala Leu Cys Ser Leu Lys Ile Ser Lys 
    130                 135                 


<210> 2073
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 2073
Leu Ala Leu Leu Ala Leu Leu Met Ser Leu Xaa Gln Gly Val Leu Xaa 
1               5                   10                  15      


Ala Leu Arg Leu Arg Lys Met Xaa Phe Gly Arg Val Ser Asp Leu Gly 
            20                  25                  30          


Gln Phe Ile Arg Glu Ser Glu Pro Glu Pro Asp Val Arg Lys Ser Lys 
        35                  40                  45              


Gly Ser Met Phe Ser Gln Ala Met Lys Lys Trp Val Gln Gly Asn Xaa 
    50                  55                  60                  


Asp Glu Ala Gln Glu Glu Leu Ala Trp Lys Ile Ala Lys Met 
65                  70                  75              


<210> 2074
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 2074
Met Arg Gly Ala Gly Pro Ser Pro Arg Gln Ser Pro Arg Xaa Leu Arg 
1               5                   10                  15      


Pro Asp Pro Gly Pro Ala Met Ser Phe Phe Arg Arg Lys Val Lys Gly 
            20                  25                  30          


Lys Glu Gln Glu Lys Xaa Ser Asp Val Lys Ser Ile Lys Ala Leu Lys 
        35                  40                  45              


Ile Met Pro Cys Trp Arg Leu Gln Asp Gln Val Met Leu Gln Ser Met 
    50                  55                  60                  


Pro Phe Leu Pro Xaa Trp Xaa Pro Phe Gln Val Ala Gly Gln Pro His 
65                  70                  75                  80  


Leu Arg Ser Ser Gln Ala Xaa Trp Arg Pro Leu Ile Leu Val Xaa Trp 
                85                  90                  95      


Ala Asp Leu Val Trp Xaa Xaa Arg Leu Lys Arg Pro Asn Gln Ala Phe 
            100                 105                 110         


Leu Arg Pro Leu Asn Lys Ser Cys Xaa Xaa Leu Leu Ser Ser Leu Xaa 
        115                 120                 125             


Ser Phe Asn Ser Trp Asn Phe Gly Glu Trp 
    130                 135             


<210> 2075
<211> 150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<400> 2075
Met Arg Gly Ala Gly Pro Ser Pro Arg Gln Ser Pro Arg Xaa Leu Arg 
1               5                   10                  15      


Pro Asp Pro Gly Pro Ala Met Ser Phe Phe Arg Arg Lys Val Lys Gly 
            20                  25                  30          


Lys Glu Gln Glu Lys Xaa Ser Asp Val Lys Ser Ile Lys Ala Ser Ile 
        35                  40                  45              


Ser Val His Ser Pro Gln Lys Ser Xaa Lys Asn His Ala Leu Leu Glu 
    50                  55                  60                  


Ala Ala Gly Pro Ser His Val Ala Ile Asn Ala Ile Ser Ala Asn Met 
65                  70                  75                  80  


Asp Ser Phe Ser Ser Ser Arg Xaa Ala Xaa Leu Lys Lys Gln Pro Ser 
                85                  90                  95      


His Met Glu Ala Ala His Phe Gly Asp Leu Asp Leu Val Trp Xaa Xaa 
            100                 105                 110         


Arg Leu Lys Arg Pro Asn Gln Ala Phe Leu Arg Pro Leu Asn Lys Ser 
        115                 120                 125             


Cys Xaa Xaa Leu Leu Ser Ser Leu Xaa Ser Phe Asn Ser Trp Asn Phe 
    130                 135                 140                 


Gly Glu Trp Ser Ile Trp 
145                 150 


<210> 2076
<211> 604
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<400> 2076
Met Arg Gly Ala Gly Pro Ser Pro Arg Gln Ser Pro Arg Xaa Leu Arg 
1               5                   10                  15      


Pro Asp Pro Gly Pro Ala Met Ser Phe Phe Arg Arg Lys Val Lys Gly 
            20                  25                  30          


Lys Glu Gln Glu Lys Xaa Ser Asp Val Lys Ser Ile Lys Ala Ser Ile 
        35                  40                  45              


Ser Val His Ser Pro Gln Lys Ser Xaa Lys Asn His Ala Leu Leu Glu 
    50                  55                  60                  


Ala Ala Gly Pro Ser His Val Ala Ile Asn Ala Ile Ser Ala Asn Met 
65                  70                  75                  80  


Asp Ser Phe Ser Ser Ser Arg Xaa Ala Xaa Leu Lys Lys Gln Pro Ser 
                85                  90                  95      


His Met Glu Ala Ala His Phe Gly Asp Leu Gly Arg Ser Cys Leu Asp 
            100                 105                 110         


Tyr Gln Xaa Gln Glu Xaa Lys Ser Ser Leu Ser Lys Xaa Leu Glu Gln 
        115                 120                 125             


Val Leu His Asp Xaa Ile Val Leu Pro Tyr Phe Ile Gln Phe Met Glu 
    130                 135                 140                 


Leu Arg Arg Met Glu His Leu Val Lys Phe Trp Leu Glu Ala Glu Ser 
145                 150                 155                 160 


Phe His Ser Xaa Xaa Trp Ser Arg Ile Arg Ala His Ser Leu Asn Xaa 
                165                 170                 175     


Val Lys Gln Ser Ser Leu Ala Glu Pro Val Ser Pro Ser Lys Lys His 
            180                 185                 190         


Glu Xaa Xaa Ala Ser Phe Leu Xaa Asp Ser Leu Asp Lys Arg Leu Glu 
        195                 200                 205             


Asp Ser Gly Ser Ala Gln Leu Phe Met Xaa His Ser Glu Gly Ile Asp 
    210                 215                 220                 


Leu Asn Asn Arg Xaa Asn Ser Xaa Gln Asn His Leu Leu Leu Ser Gln 
225                 230                 235                 240 


Glu Cys Asp Ser Ala His Ser Leu Arg Leu Glu Met Ala Arg Ala Gly 
                245                 250                 255     


Xaa His Gln Val Ser Met Glu Xaa Gln Glu Ser Ser Ser Xaa Leu Xaa 
            260                 265                 270         


Val Ala Ser Arg Asn Ser Pro Ala Ser Pro Leu Lys Glu Leu Ser Gly 
        275                 280                 285             


Lys Leu Met Lys Ser Ile Glu Gln Asp Ala Val Asn Xaa Phe Xaa Lys 
    290                 295                 300                 


Tyr Ile Ser Pro Asp Ala Ala Lys Pro Ile Pro Ile Xaa Glu Ala Met 
305                 310                 315                 320 


Arg Asn Asp Ile Ile Ala Arg Ile Cys Gly Glu Asp Gly Gln Val Asp 
                325                 330                 335     


Pro Asn Cys Phe Val Leu Ala Gln Ser Ile Val Phe Ser Ala Met Glu 
            340                 345                 350         


Gln Glu His Phe Ser Glu Phe Leu Arg Ser His His Phe Cys Lys Tyr 
        355                 360                 365             


Gln Ile Glu Val Leu Xaa Ser Gly Xaa Val Tyr Leu Ala Asp Ile Leu 
    370                 375                 380                 


Phe Cys Glu Ser Ala Leu Phe Tyr Phe Ser Glu Tyr Met Glu Lys Glu 
385                 390                 395                 400 


Asp Ala Val Asn Ile Leu Gln Phe Trp Leu Ala Ala Asp Asn Phe Gln 
                405                 410                 415     


Ser Gln Leu Ala Ala Lys Lys Gly Gln Tyr Asp Gly Gln Glu Ala Gln 
            420                 425                 430         


Asn Asp Ala Met Ile Leu Tyr Asp Lys Tyr Phe Ser Leu Gln Ala Xaa 
        435                 440                 445             


His Pro Leu Gly Phe Asp Asp Val Val Arg Leu Glu Ile Glu Ser Asn 
    450                 455                 460                 


Ile Cys Arg Glu Gly Gly Pro Leu Pro Asn Cys Phe Xaa Xaa Pro Leu 
465                 470                 475                 480 


Arg Gln Ala Trp Xaa Xaa Met Glu Lys Ser Ser Val Lys Lys Ala Ser 
                485                 490                 495     


Ile Lys Ile Leu Lys Asn Phe Asp Glu Ala Ile Ile Val Asp Ala Ala 
            500                 505                 510         


Ser Leu Asp Pro Glu Ser Leu Tyr Gln Arg Xaa Tyr Ala Gly Lys Met 
        515                 520                 525             


Xaa Phe Gly Arg Val Ser Asp Leu Gly Gln Phe Ile Arg Glu Ser Glu 
    530                 535                 540                 


Pro Glu Pro Asp Val Arg Lys Ser Lys Gly Ser Met Phe Ser Gln Ala 
545                 550                 555                 560 


Met Lys Lys Trp Val Gln Gly Asn Xaa Asp Glu Ala Gln Glu Glu Leu 
                565                 570                 575     


Ala Trp Lys Ile Ala Lys Met Ile Val Ser Asp Ile Met Gln Gln Ala 
            580                 585                 590         


Gln Tyr Asp Gln Pro Leu Glu Lys Ser Xaa Lys Leu 
        595                 600                 


<210> 2077
<211> 662
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<400> 2077
Met Arg Gly Ala Gly Pro Ser Pro Arg Gln Ser Pro Arg Xaa Leu Arg 
1               5                   10                  15      


Pro Asp Pro Gly Pro Ala Met Ser Phe Phe Arg Arg Lys Val Lys Gly 
            20                  25                  30          


Lys Glu Gln Glu Lys Xaa Ser Asp Val Lys Ser Ile Lys Ala Ser Ile 
        35                  40                  45              


Ser Val His Ser Pro Gln Lys Ser Xaa Lys Asn His Ala Leu Leu Glu 
    50                  55                  60                  


Ala Ala Gly Pro Ser His Val Ala Ile Asn Ala Ile Ser Ala Asn Met 
65                  70                  75                  80  


Asp Ser Phe Ser Ser Ser Arg Xaa Ala Xaa Leu Lys Lys Gln Pro Ser 
                85                  90                  95      


His Met Glu Ala Ala His Phe Gly Asp Leu Gly Arg Ser Cys Leu Asp 
            100                 105                 110         


Tyr Gln Xaa Gln Glu Xaa Lys Ser Ser Leu Ser Lys Xaa Leu Glu Gln 
        115                 120                 125             


Val Leu His Asp Xaa Ile Val Leu Pro Tyr Phe Ile Gln Phe Met Glu 
    130                 135                 140                 


Leu Arg Arg Met Glu His Leu Val Lys Phe Trp Leu Glu Ala Glu Ser 
145                 150                 155                 160 


Phe His Ser Xaa Xaa Trp Ser Arg Ile Arg Ala His Ser Leu Asn Xaa 
                165                 170                 175     


Val Lys Gln Ser Ser Leu Ala Glu Pro Val Ser Pro Ser Lys Lys His 
            180                 185                 190         


Glu Xaa Xaa Ala Ser Phe Leu Xaa Asp Ser Leu Asp Lys Arg Leu Glu 
        195                 200                 205             


Asp Ser Gly Ser Ala Gln Leu Phe Met Xaa His Ser Glu Gly Ile Asp 
    210                 215                 220                 


Leu Asn Asn Arg Xaa Asn Ser Xaa Gln Asn His Leu Leu Leu Ser Gln 
225                 230                 235                 240 


Glu Cys Asp Ser Ala His Ser Leu Arg Leu Glu Met Ala Arg Ala Gly 
                245                 250                 255     


Xaa His Gln Val Ser Met Glu Xaa Gln Glu Ser Ser Ser Xaa Leu Xaa 
            260                 265                 270         


Val Ala Ser Arg Asn Ser Pro Ala Ser Pro Leu Lys Glu Leu Ser Gly 
        275                 280                 285             


Lys Leu Met Lys Ser Ile Glu Gln Asp Ala Val Asn Xaa Phe Xaa Lys 
    290                 295                 300                 


Tyr Ile Ser Pro Asp Ala Ala Lys Pro Ile Pro Ile Xaa Glu Ala Met 
305                 310                 315                 320 


Arg Asn Asp Ile Ile Ala Arg Ile Cys Gly Glu Asp Gly Gln Val Asp 
                325                 330                 335     


Pro Asn Cys Phe Val Leu Ala Gln Ser Ile Val Phe Ser Ala Met Glu 
            340                 345                 350         


Gln Glu His Phe Ser Glu Phe Leu Arg Ser His His Phe Cys Lys Tyr 
        355                 360                 365             


Gln Ile Glu Val Leu Xaa Ser Gly Xaa Val Tyr Leu Ala Asp Ile Leu 
    370                 375                 380                 


Phe Cys Glu Ser Ala Leu Phe Tyr Phe Ser Glu Tyr Met Glu Lys Glu 
385                 390                 395                 400 


Asp Ala Val Asn Ile Leu Gln Phe Trp Leu Ala Ala Asp Asn Phe Gln 
                405                 410                 415     


Ser Gln Leu Ala Ala Lys Lys Gly Gln Tyr Asp Gly Gln Glu Ala Gln 
            420                 425                 430         


Asn Asp Ala Met Ile Leu Tyr Asp Lys Tyr Phe Ser Leu Gln Ala Xaa 
        435                 440                 445             


His Pro Leu Gly Phe Asp Asp Val Val Arg Leu Glu Ile Glu Ser Asn 
    450                 455                 460                 


Ile Cys Arg Glu Gly Gly Pro Leu Pro Asn Cys Phe Xaa Xaa Pro Leu 
465                 470                 475                 480 


Arg Gln Ala Trp Xaa Xaa Met Glu Lys Val Phe Leu Pro Gly Phe Leu 
                485                 490                 495     


Ser Ser Asn Leu Tyr Tyr Lys Tyr Leu Asn Asp Leu Ile His Ser Val 
            500                 505                 510         


Arg Gly Asp Glu Phe Leu Gly Gly Asn Val Ser Leu Xaa Ala Pro Gly 
        515                 520                 525             


Ser Val Gly Pro Pro Asp Glu Ser His Pro Gly Ser Ser Asp Ser Ser 
    530                 535                 540                 


Ala Ser Gln Ser Ser Val Lys Lys Ala Ser Ile Lys Ile Leu Lys Asn 
545                 550                 555                 560 


Phe Asp Glu Ala Ile Ile Val Asp Ala Ala Ser Leu Asp Pro Glu Ser 
                565                 570                 575     


Leu Tyr Gln Arg Xaa Tyr Ala Gly Lys Met Xaa Phe Gly Arg Val Ser 
            580                 585                 590         


Asp Leu Gly Gln Phe Ile Arg Glu Ser Glu Pro Glu Pro Asp Val Arg 
        595                 600                 605             


Lys Ser Lys Gly Ser Met Phe Ser Gln Ala Met Lys Lys Trp Val Gln 
    610                 615                 620                 


Gly Asn Xaa Asp Glu Ala Gln Glu Glu Leu Ala Trp Lys Ile Ala Lys 
625                 630                 635                 640 


Met Ile Val Ser Asp Ile Met Gln Gln Ala Gln Tyr Asp Gln Pro Leu 
                645                 650                 655     


Glu Lys Ser Xaa Lys Leu 
            660         


<210> 2078
<211> 66
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<400> 2078
Met Arg Gly Ala Gly Pro Ser Pro Arg Gln Ser Pro Arg Xaa Leu Arg 
1               5                   10                  15      


Pro Asp Pro Gly Pro Ala Met Ser Phe Phe Arg Arg Lys Val Lys Gly 
            20                  25                  30          


Lys Glu Gln Glu Lys Xaa Ser Asp Val Lys Ser Ile Lys Gly Cys Arg 
        35                  40                  45              


Xaa Lys Ser Cys Cys Asn Gln Cys His Phe Cys Gln His Gly Leu Leu 
    50                  55                  60                  


Phe Lys 
65      


<210> 2079
<211> 63
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<400> 2079
Met Arg Gly Ala Gly Pro Ser Pro Arg Gln Ser Pro Arg Xaa Leu Arg 
1               5                   10                  15      


Pro Asp Pro Gly Pro Ala Met Ser Phe Phe Arg Arg Lys Val Lys Gly 
            20                  25                  30          


Lys Glu Gln Glu Lys Xaa Ser Asp Val Lys Ser Ile Lys Val Glu Xaa 
        35                  40                  45              


Glu Phe His His Val Ser Gln Tyr Gly Leu Asp Leu Leu Xaa Leu 
    50                  55                  60              


<210> 2080
<211> 59
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 2080
Xaa Lys Tyr Ile Ser Pro Asp Ala Ala Lys Pro Ile Pro Ile Xaa Glu 
1               5                   10                  15      


Ala Met Arg Asn Asp Ile Ile Ala Arg Ile Cys Gly Glu Asp Gly Gln 
            20                  25                  30          


Val Asp Pro Asn Cys Phe Val Leu Ala Gln Ser Ile Val Phe Ser Ala 
        35                  40                  45              


Met Glu Gln Asp Xaa Trp Lys Lys Arg Met Gln 
    50                  55                  


<210> 2081
<211> 31
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<400> 2081
Xaa Leu Xaa Ala Pro Gly Ser Val Gly Pro Pro Asp Glu Ser His Pro 
1               5                   10                  15      


Gly Ser Ser Asp Ser Ser Ala Ser Gln Cys Glu Lys Ser Gln Tyr 
            20                  25                  30      


<210> 2082
<211> 1901
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (996)..(996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1071)..(1071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1211)..(1211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1244)..(1244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1255)..(1255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1342)..(1342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1386)..(1387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1405)..(1405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1439)..(1439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1443)..(1443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1459)..(1459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1466)..(1466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1474)..(1474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1485)..(1485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1504)..(1504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1524)..(1524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1551)..(1551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1559)..(1559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1566)..(1567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1583)..(1583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1599)..(1599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1669)..(1669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1690)..(1690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1692)..(1692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1694)..(1694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1698)..(1698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1716)..(1716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1733)..(1733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1783)..(1783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1809)..(1809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1813)..(1813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1821)..(1821)
<223> Selenocysteine

<400> 2082
Met Ala Xaa Phe Arg Asn Asn His Met Lys Xaa Lys Ala Ser Val Arg 
1               5                   10                  15      


Lys Ser Phe Ser Glu Asp Val Phe Gln Ser Val Lys Ser Leu Leu Gln 
            20                  25                  30          


Ser Gln Lys Glu Leu Cys Ser Val Xaa Ala Glu Asp Cys Leu Gln Gln 
        35                  40                  45              


Asp Glu His Ala Asn Leu Xaa Glu Val Xaa Phe Leu Gly Phe Asn Glu 
    50                  55                  60                  


Glu Xaa Asp Ala Ala His Ile Gln Asp Leu Ala Ala Val Ser Leu Glu 
65                  70                  75                  80  


Leu Pro Asp Ile Leu Asn Ser Leu His Phe Cys Ser Leu Asn Glu Asn 
                85                  90                  95      


Glu Ile Ile Cys Met Lys Asn Ile Asn Lys Pro Leu Asp Ile Ser Ser 
            100                 105                 110         


Asp Pro Leu Asn Gln Ser His Pro Ser Gly Met Leu Cys Val Met Arg 
        115                 120                 125             


Val Ser Pro Xaa Ser Pro Arg Leu Arg Ile Asp Phe Ile Phe Ser Leu 
    130                 135                 140                 


Leu Ser Lys Tyr Ala Xaa Gly Ile Arg Tyr Xaa Leu Asp Xaa Phe Leu 
145                 150                 155                 160 


His Gln Lys His Gln Leu Glu Xaa Xaa Asp Glu Asp Asp Asp Asp Xaa 
                165                 170                 175     


Asn Gln Ser Val Ser Ser Ile Glu Asp Asp Phe Val Xaa Ala Phe Glu 
            180                 185                 190         


His Leu Glu Glu Glu Glu Xaa Ser Lys Pro Tyr Asn Asp Gly Met Asn 
        195                 200                 205             


Ile Xaa Val Leu Arg Ser Gln Cys Asp Ala Ala Ser Gln Xaa Val Xaa 
    210                 215                 220                 


Gly His His Leu Glu Xaa His Asp Leu Lys Ile Leu Ile Ser Ser Gly 
225                 230                 235                 240 


Gln Gln Lys Ser Leu Ala Lys Pro Ser Xaa Ser Ser Val Asn Val Leu 
                245                 250                 255     


Gly His Lys Glu Leu Pro Ser Val Lys Xaa Ser Val Xaa Xaa Ser Ile 
            260                 265                 270         


Ser Glu Pro Trp Xaa Gln Arg Ser Phe Tyr Arg Ser Ser Asn Ala Ser 
        275                 280                 285             


Asp Lys Asp Ser Asp Leu Gln Lys Xaa Phe Phe Ser Ser Ser Pro Ala 
    290                 295                 300                 


Tyr Ser Ser Glu Ser Glu Cys Ser Ser Pro Ser Pro Val Ile Phe Leu 
305                 310                 315                 320 


Asp Glu Glu Gly Tyr Gln Lys Ser Leu Lys Ala Lys Leu Glu Leu Pro 
                325                 330                 335     


Lys Ile Pro Val Met Lys Asp Asp Ile Glu Asp Ser Asp Ser Glu Val 
            340                 345                 350         


Ser Glu Phe Phe Asp Ser Phe Asp Gln Phe Asp Glu Leu Glu Gln Xaa 
        355                 360                 365             


Leu Glu Xaa Cys Leu Phe Asn Lys Asp Pro Val Ile Gly Lys Ser Ser 
    370                 375                 380                 


Gln Arg Lys Gly His Lys His Gly Lys Ser Cys Met Asn Pro Gln Lys 
385                 390                 395                 400 


Phe Lys Phe Asp Arg Pro Ala Leu Pro Ala Asn Val Arg Lys Pro Xaa 
                405                 410                 415     


Pro Arg Lys Pro Glu Ser Pro Tyr Gly Asn Leu Cys Asp Ala Pro Asp 
            420                 425                 430         


Ser Pro Arg Pro Val Lys Ala Ser Arg Glu Asp Ser Gly Leu Phe Ser 
        435                 440                 445             


Pro Ile Arg Ser Ser Ala Phe Ser Pro Leu Gly Gly Cys Xaa Pro Ala 
    450                 455                 460                 


Glu Cys Phe Cys Gln Xaa Asp Ile Gly Gly Asp Arg Ile His Glu Asn 
465                 470                 475                 480 


His Asp Ser Val Tyr Tyr Xaa Tyr Glu Asp Tyr Ala Lys Ser Ile Ser 
                485                 490                 495     


Cys Glu Val Leu Gly Ser Val Leu Arg Xaa His His Xaa Asn Xaa Leu 
            500                 505                 510         


Ser Asn Ile Asn Ser Ile Lys His Gly Glu Asn Lys Xaa Val Xaa Phe 
        515                 520                 525             


Lys His Gly Asn Leu Asp Gln Lys Asn Lys Ser Lys Asn Lys Ser Leu 
    530                 535                 540                 


Met Ile Lys Asp Ser Ile Gln Lys Phe Ala Ala Asp Leu Val Glu Lys 
545                 550                 555                 560 


Ser Phe Gly Ser Ala Phe Lys Asp Leu Gln Lys Gly Val Ser Ser Cys 
                565                 570                 575     


Xaa Asn Ala Leu Tyr His Leu Ala Ile Lys Leu Xaa Ser Ser Val Leu 
            580                 585                 590         


Gln Met Ala Phe Asp Glu Leu Arg Arg Gln Arg Ala Phe Ser Leu Lys 
        595                 600                 605             


Glu Arg Ala Ile Ser Gly Leu Ala Asn Phe Leu Val Ser Glu Ala Leu 
    610                 615                 620                 


Ser Asn Ala Leu Lys Asp Leu Gln Tyr Val Lys Lys Gln Ile Phe Xaa 
625                 630                 635                 640 


Asn Xaa Val Ala Arg Phe Ala Ala Asp Leu Ala Glu Glu Leu Val Phe 
                645                 650                 655     


Glu Gly Ile Met Glu Val Cys Gln Phe Ser Tyr Pro Gln Xaa Pro Ala 
            660                 665                 670         


Ser Pro Gln Cys Gly Ser Phe Asp Phe Glu Asp Lys Val Val Lys Leu 
        675                 680                 685             


Tyr Ala Lys Asp Leu Ser Glu Ser Val Ile Gln Glu Ala Phe Ile Glu 
    690                 695                 700                 


Leu Ser Gln Val Asp Val Xaa Phe Xaa Xaa Lys Ala Ala Val Ser Val 
705                 710                 715                 720 


Ser Xaa Asp Asn Ile Lys Tyr Val Ser Ala Glu Ser Val Val Pro Ser 
                725                 730                 735     


Xaa Gln Ala Val Xaa Phe Ser Pro Ser Phe His Asn Gln Ala Ile Met 
            740                 745                 750         


Val Xaa Lys Pro Val Gln Glu Tyr Lys Lys Glu Tyr Xaa Val Gln Gln 
        755                 760                 765             


Ala Leu Phe Cys Xaa Ser Gly Ile Val Xaa Ser Ile Pro Val Pro Leu 
    770                 775                 780                 


Ala Gly Ser Ala Leu Leu Pro Tyr His Ile Ser Ser Xaa Ala Cys Gln 
785                 790                 795                 800 


Ala Lys Ala His Leu Ser Ser Asp Asp Ser Asn Ser Asn Gly Asp Ser 
                805                 810                 815     


Ala Gln Val His Ile Ala Xaa Lys Asn Arg Glu Glu Lys Ala Ala Cys 
            820                 825                 830         


Leu Arg Asn Ile Cys Leu Pro Ser Glu His Asn Pro Gly Asn Gln Asn 
        835                 840                 845             


Asp Phe Lys Pro Xaa Asn Asp Asp Ile Glu Met Gln Ser Ser Ser Lys 
    850                 855                 860                 


Leu Pro Asn Asp Pro Ala Ile Ile Ser Asn Phe Ser Ala Ala Val Val 
865                 870                 875                 880 


His Xaa Ile Val Asn Glu Xaa Leu Glu Ser Met Xaa Ser Leu Glu Val 
                885                 890                 895     


Xaa Lys Met Val Asp Glu Arg Xaa Asp Tyr Leu Xaa Lys Ser Leu Lys 
            900                 905                 910         


Glu Lys Xaa Pro Pro Phe Ser His Cys Asp Gln Ala Val Leu Gln Cys 
        915                 920                 925             


Ser Glu Ala Ser Ser Asn Lys Asp Met Phe Ala Asp Arg Leu Ser Lys 
    930                 935                 940                 


Ser Ile Ile Lys His Ser Ile Asp Lys Ser Lys Ser Val Ile Pro Asn 
945                 950                 955                 960 


Ile Asp Lys Asn Ala Val Tyr Lys Glu Ser Leu Pro Val Ser Gly Glu 
                965                 970                 975     


Glu Ser Gln Leu Xaa Pro Glu Lys Ser Pro Lys Phe Pro Asp Ser Gln 
            980                 985                 990         


Asn Gln Leu Xaa His Cys Ser Leu  Ser Ala Ala Lys Asp  Cys Val Pro 
        995                 1000                 1005             


Glu Cys  Lys Val Ser Met Val  His Gly Ser Ser Leu  Glu Xaa Leu 
    1010                 1015                 1020             


Pro Ser  Cys Pro Ala Val Xaa  Gly Gln Lys Ser Asp  Leu Lys Glu 
    1025                 1030                 1035             


Ser Ala  Lys Asp Gln Pro Leu  Lys Lys His Asn Leu  Asn Ser Xaa 
    1040                 1045                 1050             


Ser Leu  Glu Ala Leu Ser Phe  Gly Gln Glu Asn Pro  Phe Pro His 
    1055                 1060                 1065             


Ser His  Xaa Phe Ser Ser Xaa  Ala Leu Xaa Cys Val  Asp Gly Leu 
    1070                 1075                 1080             


His Val  Glu Asp Lys Gln Lys  Val Arg Asp Arg Asn  Val Ile Pro 
    1085                 1090                 1095             


Asp Xaa  Pro Pro Ser Xaa Pro  Leu Val Pro Ser Arg  Ala Ser Ser 
    1100                 1105                 1110             


Glu Trp  Asp Ile Lys Lys Leu  Xaa Lys Lys Leu Lys  Gly Glu Leu 
    1115                 1120                 1125             


Ala Lys  Glu Phe Ala Pro Ala  Xaa Pro Pro Ser Xaa  Pro His Asn 
    1130                 1135                 1140             


Ser Ser  Val Gly Ser Leu Ser  Glu Asn Glu Gln Asn  Xaa Ile Glu 
    1145                 1150                 1155             


Lys Glu  Glu Phe Met Leu Lys  Leu Met Arg Ser Leu  Ser Glu Glu 
    1160                 1165                 1170             


Val Glu  Ser Ser Glu Ser Gly  Glu Leu Pro Glu Val  Asp Val Lys 
    1175                 1180                 1185             


Ser Glu  His Ser Gly Lys Lys  Val Gln Phe Ala Glu  Ala Leu Ala 
    1190                 1195                 1200             


Xaa His  Ile Leu Ser Leu Ala  Xaa Glu Met Ala Ala  Ser His Leu 
    1205                 1210                 1215             


Asp Asn  Lys Ile Ile Gln Glu  Pro Lys Val Lys Asn  Pro Cys Leu 
    1220                 1225                 1230             


Asn Val  Gln Ser Gln Arg Ser  Val Ser Pro Xaa Phe  Leu Asn Pro 
    1235                 1240                 1245             


Ser Asp  Glu Asn Leu Lys Xaa  Leu Cys Asn Phe Ala  Gly Asp Leu 
    1250                 1255                 1260             


Ala Ala  Glu Val Ile Xaa Glu  Ala Glu Lys Ile Ala  Lys Val Arg 
    1265                 1270                 1275             


Asn Cys  Met Leu Phe Lys Gln  Lys Lys Asn Ser Cys  Tyr Ala Asp 
    1280                 1285                 1290             


Gly Asp  Glu Asp Tyr Lys Val  Glu Glu Lys Leu Asp  Ile Glu Ala 
    1295                 1300                 1305             


Val Val  His Pro Arg Glu Val  Asp Pro Phe Ile Leu  Ser Leu Pro 
    1310                 1315                 1320             


Pro Ser  Ser Cys Met Ser Gly  Leu Met Tyr Lys Tyr  Pro Ser Cys 
    1325                 1330                 1335             


Glu Ser  Val Xaa Asp Glu Tyr  Ala Gly His Leu Ile  Gln Ile Leu 
    1340                 1345                 1350             


Lys Gln  Glu Gly Gly Asn Ser  Glu Leu Ile Met Asp  Gln Tyr Ala 
    1355                 1360                 1365             


Asn Arg  Leu Ala Tyr Arg Ser  Val Lys Ser Gly Leu  Gln Glu Ala 
    1370                 1375                 1380             


Ala Lys  Xaa Xaa Lys Val Gln  Cys Asn Ser Arg Met  Phe Pro Val 
    1385                 1390                 1395             


Pro Ser  Ser Gln Val Lys Xaa  Asn Lys Glu Leu Leu  Met Phe Ser 
    1400                 1405                 1410             


Asn Lys  Glu His His Gln Glu  Ala Asp Lys Lys Arg  Gln Ser Lys 
    1415                 1420                 1425             


Arg Asn  Glu Gly Tyr Phe Cys  Lys Asn Gln Xaa Cys  Glu Arg Xaa 
    1430                 1435                 1440             


Leu Asp  Pro Tyr Arg Asn Glu  Val Ser Gln Leu Tyr  Ser Phe Ser 
    1445                 1450                 1455             


Xaa Ser  Leu Val His Ser Ile  Xaa Lys Asp Ala Lys  Glu Glu Leu 
    1460                 1465                 1470             


Xaa Ala  Ser Leu Val Gly Leu  Pro Lys Ser Leu Xaa  Asp Ser Cys 
    1475                 1480                 1485             


Leu Phe  Glu Lys Ser Gly Tyr  Glu Glu Asp Asn Glu  Cys His Val 
    1490                 1495                 1500             


Xaa Pro  Glu Leu Pro Lys Ser  Leu Gln Pro Ser Ser  Gln Asn His 
    1505                 1510                 1515             


Arg Phe  Tyr His Ser Xaa Gly  Ser Leu Asn Gly Tyr  Gly Cys Gly 
    1520                 1525                 1530             


Asp Asn  Val Val Gln Ala Val  Glu Gln Tyr Ala Lys  Lys Val Val 
    1535                 1540                 1545             


Asp Asp  Xaa Leu Glu Leu Xaa  Leu Gly Ser Xaa Val  Phe Arg Val 
    1550                 1555                 1560             


Ser Glu  Xaa Xaa Lys Ser Ala  Asp Arg Val Xaa Tyr  Ala Glu Lys 
    1565                 1570                 1575             


Leu Ser  Pro Leu Xaa Gly Gln  Ala Cys Arg Tyr Cys  Asp Leu Lys 
    1580                 1585                 1590             


Glu Leu  His Asn Cys Xaa Gly  Asn Ser Ser Gln His  Phe Phe Arg 
    1595                 1600                 1605             


Gln Gly  Ser Leu Ala Ser Ser  Lys Pro Ala Ser Asn  Pro Lys Phe 
    1610                 1615                 1620             


Ser Ser  Arg Tyr Gln Lys Ser  Arg Ile Phe His Leu  Ser Val Pro 
    1625                 1630                 1635             


Gln Ile  His Val Asn Leu Asp  Lys Lys Ala Val Leu  Ala Glu Lys 
    1640                 1645                 1650             


Ile Val  Ala Glu Ala Ile Glu  Lys Ala Glu Arg Glu  Leu Ser Ser 
    1655                 1660                 1665             


Xaa Ser  Leu Ala Ala Asp Ser  Gly Ile Gly Gln Glu  Gly Ala Ser 
    1670                 1675                 1680             


Phe Ala  Glu Ser Leu Ala Xaa  Glu Xaa Met Xaa Ala  Ala Val Xaa 
    1685                 1690                 1695             


Asn Val  Gly His Ala Val Ser  Ser Ser Lys Glu Ile  Glu Asp Phe 
    1700                 1705                 1710             


Gln Ser  Xaa Glu Ser Val Ser  Ser Gln Gln Met Asn  Leu Ser Ile 
    1715                 1720                 1725             


Gly Asp  Asp Ser Xaa Gly Ser  Trp Ser Asn Leu Ser  Phe Glu Asp 
    1730                 1735                 1740             


Glu His  Gln Asp Glu Ser Ser  Ser Phe His His Leu  Ser Glu Ser 
    1745                 1750                 1755             


Asn Gly  Asn Ser Ser Ser Trp  Ser Ser Leu Gly Leu  Glu Gly Asp 
    1760                 1765                 1770             


Leu Tyr  Glu Asp Asn Leu Ser  Phe Pro Xaa Ser Asp  Ser Asp Gly 
    1775                 1780                 1785             


Pro Asp  Asp Lys Asp Glu Glu  His Glu Asp Glu Val  Glu Gly Leu 
    1790                 1795                 1800             


Gly Gln  Asp Gly Lys Xaa Leu  Leu Ile Xaa Asn Ile  Asp Met Glu 
    1805                 1810                 1815             


Pro Cys  Xaa Val Asp Pro Gln  Leu Arg Ile Ile Leu  Gln Trp Leu 
    1820                 1825                 1830             


Ile Ala  Ser Glu Ala Glu Val  Ala Glu Leu Tyr Phe  His Asp Ser 
    1835                 1840                 1845             


Ala Asn  Lys Glu Phe Met Leu  Leu Ser Lys Gln Leu  Gln Glu Lys 
    1850                 1855                 1860             


Gly Trp  Lys Val Gly Asp Leu  Leu Gln Ala Val Leu  Gln Tyr Tyr 
    1865                 1870                 1875             


Glu Val  Met Glu Lys Ala Ser  Ser Glu Glu Arg Cys  Lys Ser Leu 
    1880                 1885                 1890             


Phe Asp  Trp Leu Leu Glu Asn  Ala 
    1895                 1900     


<210> 2083
<211> 1782
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1103)..(1103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1107)..(1107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1246)..(1246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1293)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1300)..(1300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1346)..(1346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1365)..(1365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1377)..(1377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1422)..(1422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1440)..(1440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1443)..(1443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1475)..(1475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1484)..(1484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1491)..(1492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1505)..(1506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1544)..(1544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1556)..(1556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1564)..(1564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1567)..(1567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1569)..(1569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1578)..(1578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1612)..(1612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1641)..(1641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1643)..(1643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1650)..(1650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1672)..(1672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1717)..(1717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1724)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1730)..(1730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1780)..(1780)
<223> Selenocysteine

<400> 2083
Met Gly Ala Gly Ser Ser Xaa Glu Gln Arg Ser Pro Glu Gln Pro Pro 
1               5                   10                  15      


Glu Gly Ser Ser Xaa Pro Ala Glu Pro Glu Pro Ser Gly Gly Gly Pro 
            20                  25                  30          


Ser Ala Glu Ala Ala Pro Asp Xaa Xaa Ala Asp Pro Ala Ile Ala Ala 
        35                  40                  45              


Ser Asp Pro Ala Xaa Lys Leu Leu Gln Lys Asn Gly Gln Leu Ser Xaa 
    50                  55                  60                  


Ile Asn Gly Val Ala Glu Gln Asp Glu Leu Ser Leu Gln Glu Gly Asp 
65                  70                  75                  80  


Leu Asn Gly Gln Lys Gly Ala Leu Asn Gly Gln Gly Ala Leu Asn Ser 
                85                  90                  95      


Gln Glu Glu Glu Glu Val Ile Val Xaa Glu Val Gly Gln Arg Asp Ser 
            100                 105                 110         


Glu Asp Val Ser Lys Arg Asp Ser Asp Lys Glu Met Ala Xaa Lys Ser 
        115                 120                 125             


Ala Val Val His Asp Ile Xaa Asp Asp Gly Gln Glu Glu Xaa Pro Glu 
    130                 135                 140                 


Ile Ile Glu Gln Ile Pro Ser Ser Glu Ser Asn Leu Glu Glu Leu Xaa 
145                 150                 155                 160 


Gln Pro Xaa Glu Ser Gln Ala Asn Asp Ile Gly Phe Lys Lys Val Phe 
                165                 170                 175     


Lys Phe Val Gly Phe Lys Phe Xaa Val Lys Lys Asp Lys Xaa Glu Lys 
            180                 185                 190         


Pro Asp Xaa Val Gln Leu Leu Xaa Val Lys Lys Asp Glu Gly Glu Gly 
        195                 200                 205             


Ala Ala Gly Ala Gly Asp His Lys Asp Pro Ser Leu Gly Ala Gly Glu 
    210                 215                 220                 


Ala Ala Ser Lys Glu Ser Glu Pro Lys Gln Ser Xaa Glu Lys Pro Glu 
225                 230                 235                 240 


Glu Xaa Leu Lys Arg Glu Gln Ser His Ala Glu Ile Ser Pro Pro Ala 
                245                 250                 255     


Glu Ser Gly Gln Ala Val Glu Glu Cys Lys Glu Glu Gly Glu Glu Lys 
            260                 265                 270         


Gln Glu Lys Glu Pro Ser Lys Ser Ala Glu Ser Pro Xaa Ser Pro Val 
        275                 280                 285             


Xaa Ser Glu Xaa Gly Ser Xaa Phe Lys Lys Phe Phe Xaa Gln Gly Trp 
    290                 295                 300                 


Ala Gly Trp Arg Lys Lys Xaa Ser Phe Arg Lys Pro Lys Glu Asp Glu 
305                 310                 315                 320 


Val Glu Ala Ser Glu Lys Lys Lys Glu Gln Glu Pro Glu Lys Val Asp 
                325                 330                 335     


Xaa Glu Glu Asp Gly Lys Ala Glu Val Ala Ser Glu Lys Leu Xaa Ala 
            340                 345                 350         


Ser Glu Gln Ala His Pro Gln Glu Pro Ala Glu Ser Ala His Glu Pro 
        355                 360                 365             


Arg Leu Ser Ala Glu Tyr Glu Lys Val Glu Leu Pro Ser Glu Glu Gln 
    370                 375                 380                 


Val Ser Gly Ser Gln Gly Pro Ser Glu Glu Lys Pro Ala Pro Leu Ala 
385                 390                 395                 400 


Xaa Glu Val Phe Asp Glu Lys Ile Glu Val His Gln Glu Glu Val Val 
                405                 410                 415     


Ala Glu Val His Val Ser Xaa Val Glu Glu Arg Xaa Glu Glu Gln Lys 
            420                 425                 430         


Xaa Glu Val Glu Glu Xaa Ala Gly Ser Val Pro Ala Glu Glu Leu Val 
        435                 440                 445             


Glu Met Asp Ala Glu Pro Gln Glu Ala Glu Pro Ala Lys Glu Leu Val 
    450                 455                 460                 


Lys Leu Lys Glu Xaa Cys Val Ser Gly Glu Asp Pro Xaa Gln Gly Ala 
465                 470                 475                 480 


Asp Leu Ser Pro Asp Glu Lys Val Leu Ser Lys Pro Pro Glu Gly Val 
                485                 490                 495     


Val Ser Glu Val Glu Met Leu Ser Ser Gln Glu Arg Met Lys Val Gln 
            500                 505                 510         


Gly Ser Pro Leu Lys Lys Leu Phe Xaa Ser Xaa Gly Leu Lys Lys Leu 
        515                 520                 525             


Ser Gly Lys Lys Gln Lys Gly Lys Arg Gly Gly Gly Asp Glu Glu Ser 
    530                 535                 540                 


Gly Glu His Xaa Gln Val Pro Ala Asp Ser Pro Asp Ser Gln Glu Glu 
545                 550                 555                 560 


Gln Lys Gly Glu Ser Ser Ala Ser Ser Pro Glu Glu Pro Glu Glu Ile 
                565                 570                 575     


Xaa Cys Leu Glu Lys Gly Leu Ala Glu Val Gln Gln Asp Gly Glu Ala 
            580                 585                 590         


Glu Glu Gly Ala Xaa Ser Asp Gly Glu Lys Lys Arg Glu Gly Val Xaa 
        595                 600                 605             


Pro Trp Ala Ser Phe Lys Lys Met Val Xaa Pro Lys Lys Arg Val Arg 
    610                 615                 620                 


Arg Pro Ser Glu Ser Asp Lys Glu Asp Glu Leu Asp Lys Val Lys Ser 
625                 630                 635                 640 


Ala Xaa Leu Ser Ser Xaa Glu Ser Xaa Ala Ser Glu Met Gln Glu Glu 
                645                 650                 655     


Met Lys Gly Ser Val Glu Glu Pro Lys Pro Glu Glu Pro Lys Arg Lys 
            660                 665                 670         


Val Asp Xaa Ser Val Ser Trp Glu Ala Leu Ile Cys Val Gly Ser Ser 
        675                 680                 685             


Lys Lys Arg Ala Arg Arg Gly Ser Ser Ser Asp Glu Glu Gly Gly Pro 
    690                 695                 700                 


Lys Ala Met Gly Gly Asp His Gln Lys Ala Asp Glu Ala Gly Lys Asp 
705                 710                 715                 720 


Lys Glu Xaa Gly Xaa Asp Gly Ile Leu Ala Gly Ser Gln Glu His Asp 
                725                 730                 735     


Pro Gly Gln Gly Ser Ser Ser Pro Glu Gln Ala Gly Ser Pro Xaa Glu 
            740                 745                 750         


Gly Glu Gly Val Ser Xaa Trp Glu Ser Phe Lys Arg Leu Val Xaa Pro 
        755                 760                 765             


Arg Lys Lys Ser Lys Ser Lys Leu Glu Glu Lys Ser Glu Asp Ser Ile 
    770                 775                 780                 


Ala Gly Ser Gly Val Glu His Ser Xaa Pro Asp Xaa Glu Pro Gly Lys 
785                 790                 795                 800 


Glu Glu Ser Trp Val Ser Ile Lys Lys Phe Ile Pro Gly Arg Arg Lys 
                805                 810                 815     


Lys Arg Pro Asp Gly Lys Gln Glu Gln Ala Pro Val Glu Asp Ala Gly 
            820                 825                 830         


Pro Xaa Gly Ala Asn Glu Asp Asp Ser Asp Val Pro Ala Val Val Pro 
        835                 840                 845             


Leu Ser Glu Tyr Asp Ala Val Glu Arg Glu Lys Met Glu Ala Gln Gln 
    850                 855                 860                 


Ala Gln Lys Ser Ala Glu Gln Pro Glu Gln Lys Ala Ala Xaa Glu Val 
865                 870                 875                 880 


Ser Lys Glu Leu Ser Glu Ser Gln Val His Met Met Ala Ala Ala Val 
                885                 890                 895     


Ala Asp Gly Xaa Arg Ala Ala Xaa Ile Ile Glu Glu Arg Ser Pro Ser 
            900                 905                 910         


Trp Ile Ser Ala Ser Val Xaa Glu Pro Leu Glu Gln Val Glu Ala Glu 
        915                 920                 925             


Ala Ala Leu Leu Xaa Glu Glu Val Leu Glu Arg Glu Val Ile Ala Glu 
    930                 935                 940                 


Glu Glu Pro Pro Xaa Val Xaa Glu Pro Leu Pro Glu Asn Arg Glu Ala 
945                 950                 955                 960 


Arg Gly Asp Xaa Val Val Ser Glu Ala Glu Leu Xaa Pro Glu Ala Val 
                965                 970                 975     


Xaa Ala Ala Glu Xaa Ala Gly Pro Leu Gly Ala Glu Glu Gly Xaa Glu 
            980                 985                 990         


Ala Ser Ala Ala Glu Glu Xaa Xaa  Glu Met Val Ser Ala  Val Ser Gln 
        995                 1000                 1005             


Leu Xaa  Asp Ser Pro Asp Xaa  Xaa Glu Glu Ala Xaa  Pro Val Gln 
    1010                 1015                 1020             


Glu Val  Glu Gly Gly Val Pro  Asp Ile Glu Glu Gln  Glu Arg Arg 
    1025                 1030                 1035             


Xaa Gln  Glu Val Leu Gln Ala  Val Ala Glu Lys Val  Lys Glu Glu 
    1040                 1045                 1050             


Ser Gln  Leu Pro Gly Xaa Gly  Gly Pro Glu Asp Val  Leu Gln Pro 
    1055                 1060                 1065             


Val Gln  Arg Ala Glu Ala Glu  Arg Pro Glu Glu Gln  Ala Glu Ala 
    1070                 1075                 1080             


Ser Gly  Leu Lys Lys Glu Xaa  Asp Val Val Leu Lys  Val Asp Ala 
    1085                 1090                 1095             


Gln Glu  Ala Lys Xaa Glu Pro  Phe Xaa Gln Gly Lys  Val Val Gly 
    1100                 1105                 1110             


Gln Xaa  Xaa Pro Glu Ser Phe  Glu Lys Ala Pro Gln  Val Xaa Glu 
    1115                 1120                 1125             


Ser Ile  Glu Ser Ser Glu Leu  Val Xaa Xaa Cys Gln  Ala Glu Xaa 
    1130                 1135                 1140             


Leu Ala  Gly Val Lys Ser Gln  Glu Met Val Met Glu  Gln Ala Ile 
    1145                 1150                 1155             


Pro Pro  Asp Ser Val Glu Xaa  Pro Xaa Asp Ser Glu  Xaa Asp Gly 
    1160                 1165                 1170             


Ser Xaa  Pro Val Ala Asp Phe  Asp Ala Pro Gly Xaa  Xaa Gln Lys 
    1175                 1180                 1185             


Asp Glu  Ile Val Glu Ile His  Glu Glu Asn Glu Val  Ala Ser Gly 
    1190                 1195                 1200             


Xaa Gln  Ser Gly Gly Xaa Glu  Ala Glu Ala Val Pro  Ala Gln Lys 
    1205                 1210                 1215             


Glu Arg  Pro Pro Ala Pro Ser  Ser Phe Val Phe Gln  Glu Glu Xaa 
    1220                 1225                 1230             


Lys Glu  Gln Ser Lys Met Glu  Asp Xaa Leu Glu His  Xaa Asp Lys 
    1235                 1240                 1245             


Glu Val  Ser Val Glu Xaa Val  Ser Ile Leu Ser Lys  Xaa Glu Gly 
    1250                 1255                 1260             


Xaa Gln  Glu Ala Asp Gln Tyr  Ala Asp Glu Lys Xaa  Lys Asp Val 
    1265                 1270                 1275             


Pro Phe  Phe Glu Gly Leu Glu  Gly Ser Ile Asp Xaa  Gly Ile Xaa 
    1280                 1285                 1290             


Val Ser  Arg Glu Lys Val Xaa  Glu Val Ala Leu Lys  Gly Glu Gly 
    1295                 1300                 1305             


Xaa Glu  Glu Ala Glu Cys Lys  Lys Asp Asp Ala Leu  Glu Leu Gln 
    1310                 1315                 1320             


Ser His  Ala Lys Ser Pro Pro  Ser Pro Val Glu Arg  Glu Met Val 
    1325                 1330                 1335             


Val Gln  Val Glu Arg Glu Lys  Xaa Glu Ala Glu Pro  Xaa His Val 
    1340                 1345                 1350             


Asn Glu  Glu Lys Leu Glu His  Glu Xaa Ala Val Xaa  Val Ser Glu 
    1355                 1360                 1365             


Glu Val  Ser Lys Gln Leu Leu  Gln Xaa Val Asn Val  Pro Ile Ile 
    1370                 1375                 1380             


Asp Gly  Ala Lys Glu Val Ser  Ser Leu Glu Gly Ser  Pro Pro Pro 
    1385                 1390                 1395             


Cys Leu  Gly Gln Glu Glu Ala  Val Cys Xaa Lys Ile  Gln Val Gln 
    1400                 1405                 1410             


Ser Ser  Glu Ala Ser Phe Xaa  Leu Xaa Ala Ala Ala  Glu Glu Glu 
    1415                 1420                 1425             


Lys Val  Leu Gly Glu Xaa Ala  Asn Ile Leu Glu Xaa  Gly Glu Xaa 
    1430                 1435                 1440             


Leu Glu  Pro Ala Gly Ala His  Leu Val Leu Glu Glu  Lys Ser Ser 
    1445                 1450                 1455             


Glu Lys  Asn Glu Asp Phe Ala  Ala His Pro Gly Glu  Asp Ala Val 
    1460                 1465                 1470             


Pro Xaa  Gly Pro Asp Cys Gln  Ala Lys Ser Xaa Pro  Val Ile Val 
    1475                 1480                 1485             


Ser Ala  Xaa Xaa Lys Lys Gly  Leu Ser Ser Asp Leu  Glu Gly Glu 
    1490                 1495                 1500             


Lys Xaa  Xaa Ser Leu Lys Trp  Lys Ser Asp Glu Val  Asp Glu Gln 
    1505                 1510                 1515             


Val Ala  Cys Gln Glu Val Lys  Val Ser Val Ala Ile  Glu Asp Leu 
    1520                 1525                 1530             


Glu Pro  Glu Asn Gly Ile Leu  Glu Leu Glu Xaa Lys  Ser Ser Lys 
    1535                 1540                 1545             


Leu Val  Gln Asn Ile Ile Gln  Xaa Ala Val Asp Gln  Phe Val Arg 
    1550                 1555                 1560             


Xaa Glu  Glu Xaa Ala Xaa Glu  Met Leu Xaa Ser Glu  Leu Gln Xaa 
    1565                 1570                 1575             


Gln Ala  His Val Ile Lys Ala  Asp Ser Gln Asp Ala  Gly Gln Glu 
    1580                 1585                 1590             


Xaa Glu  Lys Glu Gly Glu Glu  Pro Gln Ala Ser Ala  Gln Asp Glu 
    1595                 1600                 1605             


Xaa Pro  Ile Xaa Ser Ala Lys  Glu Glu Ser Glu Ser  Xaa Ala Val 
    1610                 1615                 1620             


Gly Gln  Ala His Ser Asp Ile  Ser Lys Asp Met Ser  Glu Ala Ser 
    1625                 1630                 1635             


Glu Lys  Xaa Met Xaa Val Glu  Val Glu Gly Ser Xaa  Val Asn Asp 
    1640                 1645                 1650             


Gln Gln  Leu Glu Glu Val Val  Leu Pro Ser Glu Glu  Glu Gly Gly 
    1655                 1660                 1665             


Gly Ala  Gly Xaa Lys Ser Val  Pro Glu Asp Asp Gly  His Ala Leu 
    1670                 1675                 1680             


Leu Ala  Glu Arg Ile Glu Lys  Ser Leu Val Glu Pro  Lys Glu Asp 
    1685                 1690                 1695             


Glu Lys  Gly Asp Asp Val Asp  Asp Pro Glu Asn Gln  Asn Ser Ala 
    1700                 1705                 1710             


Leu Ala  Asp Xaa Asp Ala Ser  Gly Gly Leu Xaa Lys  Glu Ser Pro 
    1715                 1720                 1725             


Asp Xaa  Asn Gly Pro Lys Gln  Lys Glu Lys Glu Asp  Ala Gln Glu 
    1730                 1735                 1740             


Val Glu  Leu Gln Glu Gly Lys  Val His Ser Glu Ser  Asp Lys Ala 
    1745                 1750                 1755             


Ile Xaa  Pro Gln Ala Gln Glu  Glu Leu Gln Lys Gln  Glu Arg Glu 
    1760                 1765                 1770             


Ser Ala  Lys Ser Glu Leu Xaa  Glu Ser 
    1775                 1780         


<210> 2084
<211> 1684
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1017)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1106)..(1106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1195)..(1195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1211)..(1211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1248)..(1248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1253)..(1253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1267)..(1267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1322)..(1322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1324)..(1324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1342)..(1342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1377)..(1377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1386)..(1386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1393)..(1394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1466)..(1466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1469)..(1469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1471)..(1471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1475)..(1475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1480)..(1480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1496)..(1496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1511)..(1511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1514)..(1514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1523)..(1523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1543)..(1543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1552)..(1552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1619)..(1619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1626)..(1626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1632)..(1632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1662)..(1662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1682)..(1682)
<223> Selenocysteine

<400> 2084
Met Leu Gly Xaa Ile Xaa Ile Xaa Val Gly Gln Arg Asp Ser Glu Asp 
1               5                   10                  15      


Val Ser Lys Arg Asp Ser Asp Lys Glu Met Ala Xaa Lys Ser Ala Val 
            20                  25                  30          


Val His Asp Ile Xaa Asp Asp Gly Gln Glu Glu Xaa Pro Glu Ile Ile 
        35                  40                  45              


Glu Gln Ile Pro Ser Ser Glu Ser Asn Leu Glu Glu Leu Xaa Gln Pro 
    50                  55                  60                  


Xaa Glu Ser Gln Ala Asn Asp Ile Gly Phe Lys Lys Val Phe Lys Phe 
65                  70                  75                  80  


Val Gly Phe Lys Phe Xaa Val Lys Lys Asp Lys Xaa Glu Lys Pro Asp 
                85                  90                  95      


Xaa Val Gln Leu Leu Xaa Val Lys Lys Asp Glu Gly Glu Gly Ala Ala 
            100                 105                 110         


Gly Ala Gly Asp His Lys Asp Pro Ser Leu Gly Ala Gly Glu Ala Ala 
        115                 120                 125             


Ser Lys Glu Ser Glu Pro Lys Gln Ser Xaa Glu Lys Pro Glu Glu Xaa 
    130                 135                 140                 


Leu Lys Arg Glu Gln Ser His Ala Glu Ile Ser Pro Pro Ala Glu Ser 
145                 150                 155                 160 


Gly Gln Ala Val Glu Glu Cys Lys Glu Glu Gly Glu Glu Lys Gln Glu 
                165                 170                 175     


Lys Glu Pro Ser Lys Ser Ala Glu Ser Pro Xaa Ser Pro Val Xaa Ser 
            180                 185                 190         


Glu Xaa Gly Ser Xaa Phe Lys Lys Phe Phe Xaa Gln Gly Trp Ala Gly 
        195                 200                 205             


Trp Arg Lys Lys Xaa Ser Phe Arg Lys Pro Lys Glu Asp Glu Val Glu 
    210                 215                 220                 


Ala Ser Glu Lys Lys Lys Glu Gln Glu Pro Glu Lys Val Asp Xaa Glu 
225                 230                 235                 240 


Glu Asp Gly Lys Ala Glu Val Ala Ser Glu Lys Leu Xaa Ala Ser Glu 
                245                 250                 255     


Gln Ala His Pro Gln Glu Pro Ala Glu Ser Ala His Glu Pro Arg Leu 
            260                 265                 270         


Ser Ala Glu Tyr Glu Lys Val Glu Leu Pro Ser Glu Glu Gln Val Ser 
        275                 280                 285             


Gly Ser Gln Gly Pro Ser Glu Glu Lys Pro Ala Pro Leu Ala Xaa Glu 
    290                 295                 300                 


Val Phe Asp Glu Lys Ile Glu Val His Gln Glu Glu Val Val Ala Glu 
305                 310                 315                 320 


Val His Val Ser Xaa Val Glu Glu Arg Xaa Glu Glu Gln Lys Xaa Glu 
                325                 330                 335     


Val Glu Glu Xaa Ala Gly Ser Val Pro Ala Glu Glu Leu Val Glu Met 
            340                 345                 350         


Asp Ala Glu Pro Gln Glu Ala Glu Pro Ala Lys Glu Leu Val Lys Leu 
        355                 360                 365             


Lys Glu Xaa Cys Val Ser Gly Glu Asp Pro Xaa Gln Gly Ala Asp Leu 
    370                 375                 380                 


Ser Pro Asp Glu Lys Val Leu Ser Lys Pro Pro Glu Gly Val Val Ser 
385                 390                 395                 400 


Glu Val Glu Met Leu Ser Ser Gln Glu Arg Met Lys Val Gln Gly Ser 
                405                 410                 415     


Pro Leu Lys Lys Leu Phe Xaa Ser Xaa Gly Leu Lys Lys Leu Ser Gly 
            420                 425                 430         


Lys Lys Gln Lys Gly Lys Arg Gly Gly Gly Asp Glu Glu Ser Gly Glu 
        435                 440                 445             


His Xaa Gln Val Pro Ala Asp Ser Pro Asp Ser Gln Glu Glu Gln Lys 
    450                 455                 460                 


Gly Glu Ser Ser Ala Ser Ser Pro Glu Glu Pro Glu Glu Ile Xaa Cys 
465                 470                 475                 480 


Leu Glu Lys Gly Leu Ala Glu Val Gln Gln Asp Gly Glu Ala Glu Glu 
                485                 490                 495     


Gly Ala Xaa Ser Asp Gly Glu Lys Lys Arg Glu Gly Val Xaa Pro Trp 
            500                 505                 510         


Ala Ser Phe Lys Lys Met Val Xaa Pro Lys Lys Arg Val Arg Arg Pro 
        515                 520                 525             


Ser Glu Ser Asp Lys Glu Asp Glu Leu Asp Lys Val Lys Ser Ala Xaa 
    530                 535                 540                 


Leu Ser Ser Xaa Glu Ser Xaa Ala Ser Glu Met Gln Glu Glu Met Lys 
545                 550                 555                 560 


Gly Ser Val Glu Glu Pro Lys Pro Glu Glu Pro Lys Arg Lys Val Asp 
                565                 570                 575     


Xaa Ser Val Ser Trp Glu Ala Leu Ile Cys Val Gly Ser Ser Lys Lys 
            580                 585                 590         


Arg Ala Arg Arg Gly Ser Ser Ser Asp Glu Glu Gly Gly Pro Lys Ala 
        595                 600                 605             


Met Gly Gly Asp His Gln Lys Ala Asp Glu Ala Gly Lys Asp Lys Glu 
    610                 615                 620                 


Xaa Gly Xaa Asp Gly Ile Leu Ala Gly Ser Gln Glu His Asp Pro Gly 
625                 630                 635                 640 


Gln Gly Ser Ser Ser Pro Glu Gln Ala Gly Ser Pro Xaa Glu Gly Glu 
                645                 650                 655     


Gly Val Ser Xaa Trp Glu Ser Phe Lys Arg Leu Val Xaa Pro Arg Lys 
            660                 665                 670         


Lys Ser Lys Ser Lys Leu Glu Glu Lys Ser Glu Asp Ser Ile Ala Gly 
        675                 680                 685             


Ser Gly Val Glu His Ser Xaa Pro Asp Xaa Glu Pro Gly Lys Glu Glu 
    690                 695                 700                 


Ser Trp Val Ser Ile Lys Lys Phe Ile Pro Gly Arg Arg Lys Lys Arg 
705                 710                 715                 720 


Pro Asp Gly Lys Gln Glu Gln Ala Pro Val Glu Asp Ala Gly Pro Xaa 
                725                 730                 735     


Gly Ala Asn Glu Asp Asp Ser Asp Val Pro Ala Val Val Pro Leu Ser 
            740                 745                 750         


Glu Tyr Asp Ala Val Glu Arg Glu Lys Met Glu Ala Gln Gln Ala Gln 
        755                 760                 765             


Lys Ser Ala Glu Gln Pro Glu Gln Lys Ala Ala Xaa Glu Val Ser Lys 
    770                 775                 780                 


Glu Leu Ser Glu Ser Gln Val His Met Met Ala Ala Ala Val Ala Asp 
785                 790                 795                 800 


Gly Xaa Arg Ala Ala Xaa Ile Ile Glu Glu Arg Ser Pro Ser Trp Ile 
                805                 810                 815     


Ser Ala Ser Val Xaa Glu Pro Leu Glu Gln Val Glu Ala Glu Ala Ala 
            820                 825                 830         


Leu Leu Xaa Glu Glu Val Leu Glu Arg Glu Val Ile Ala Glu Glu Glu 
        835                 840                 845             


Pro Pro Xaa Val Xaa Glu Pro Leu Pro Glu Asn Arg Glu Ala Arg Gly 
    850                 855                 860                 


Asp Xaa Val Val Ser Glu Ala Glu Leu Xaa Pro Glu Ala Val Xaa Ala 
865                 870                 875                 880 


Ala Glu Xaa Ala Gly Pro Leu Gly Ala Glu Glu Gly Xaa Glu Ala Ser 
                885                 890                 895     


Ala Ala Glu Glu Xaa Xaa Glu Met Val Ser Ala Val Ser Gln Leu Xaa 
            900                 905                 910         


Asp Ser Pro Asp Xaa Xaa Glu Glu Ala Xaa Pro Val Gln Glu Val Glu 
        915                 920                 925             


Gly Gly Val Pro Asp Ile Glu Glu Gln Glu Arg Arg Xaa Gln Glu Val 
    930                 935                 940                 


Leu Gln Ala Val Ala Glu Lys Val Lys Glu Glu Ser Gln Leu Pro Gly 
945                 950                 955                 960 


Xaa Gly Gly Pro Glu Asp Val Leu Gln Pro Val Gln Arg Ala Glu Ala 
                965                 970                 975     


Glu Arg Pro Glu Glu Gln Ala Glu Ala Ser Gly Leu Lys Lys Glu Xaa 
            980                 985                 990         


Asp Val Val Leu Lys Val Asp Ala  Gln Glu Ala Lys Xaa  Glu Pro Phe 
        995                 1000                 1005             


Xaa Gln  Gly Lys Val Val Gly  Gln Xaa Xaa Pro Glu  Ser Phe Glu 
    1010                 1015                 1020             


Lys Ala  Pro Gln Val Xaa Glu  Ser Ile Glu Ser Ser  Glu Leu Val 
    1025                 1030                 1035             


Xaa Xaa  Cys Gln Ala Glu Xaa  Leu Ala Gly Val Lys  Ser Gln Glu 
    1040                 1045                 1050             


Met Val  Met Glu Gln Ala Ile  Pro Pro Asp Ser Val  Glu Xaa Pro 
    1055                 1060                 1065             


Xaa Asp  Ser Glu Xaa Asp Gly  Ser Xaa Pro Val Ala  Asp Phe Asp 
    1070                 1075                 1080             


Ala Pro  Gly Xaa Xaa Gln Lys  Asp Glu Ile Val Glu  Ile His Glu 
    1085                 1090                 1095             


Glu Asn  Glu Val Ala Ser Gly  Xaa Gln Ser Gly Gly  Xaa Glu Ala 
    1100                 1105                 1110             


Glu Ala  Val Pro Ala Gln Lys  Glu Arg Pro Pro Ala  Pro Ser Ser 
    1115                 1120                 1125             


Phe Val  Phe Gln Glu Glu Xaa  Lys Glu Gln Ser Lys  Met Glu Asp 
    1130                 1135                 1140             


Xaa Leu  Glu His Xaa Asp Lys  Glu Val Ser Val Glu  Xaa Val Ser 
    1145                 1150                 1155             


Ile Leu  Ser Lys Xaa Glu Gly  Xaa Gln Glu Ala Asp  Gln Tyr Ala 
    1160                 1165                 1170             


Asp Glu  Lys Xaa Lys Asp Val  Pro Phe Phe Glu Gly  Leu Glu Gly 
    1175                 1180                 1185             


Ser Ile  Asp Xaa Gly Ile Xaa  Val Ser Arg Glu Lys  Val Xaa Glu 
    1190                 1195                 1200             


Val Ala  Leu Lys Gly Glu Gly  Xaa Glu Glu Ala Glu  Cys Lys Lys 
    1205                 1210                 1215             


Asp Asp  Ala Leu Glu Leu Gln  Ser His Ala Lys Ser  Pro Pro Ser 
    1220                 1225                 1230             


Pro Val  Glu Arg Glu Met Val  Val Gln Val Glu Arg  Glu Lys Xaa 
    1235                 1240                 1245             


Glu Ala  Glu Pro Xaa His Val  Asn Glu Glu Lys Leu  Glu His Glu 
    1250                 1255                 1260             


Xaa Ala  Val Xaa Val Ser Glu  Glu Val Ser Lys Gln  Leu Leu Gln 
    1265                 1270                 1275             


Xaa Val  Asn Val Pro Ile Ile  Asp Gly Ala Lys Glu  Val Ser Ser 
    1280                 1285                 1290             


Leu Glu  Gly Ser Pro Pro Pro  Cys Leu Gly Gln Glu  Glu Ala Val 
    1295                 1300                 1305             


Cys Xaa  Lys Ile Gln Val Gln  Ser Ser Glu Ala Ser  Phe Xaa Leu 
    1310                 1315                 1320             


Xaa Ala  Ala Ala Glu Glu Glu  Lys Val Leu Gly Glu  Xaa Ala Asn 
    1325                 1330                 1335             


Ile Leu  Glu Xaa Gly Glu Xaa  Leu Glu Pro Ala Gly  Ala His Leu 
    1340                 1345                 1350             


Val Leu  Glu Glu Lys Ser Ser  Glu Lys Asn Glu Asp  Phe Ala Ala 
    1355                 1360                 1365             


His Pro  Gly Glu Asp Ala Val  Pro Xaa Gly Pro Asp  Cys Gln Ala 
    1370                 1375                 1380             


Lys Ser  Xaa Pro Val Ile Val  Ser Ala Xaa Xaa Lys  Lys Gly Leu 
    1385                 1390                 1395             


Ser Ser  Asp Leu Glu Gly Glu  Lys Xaa Xaa Ser Leu  Lys Trp Lys 
    1400                 1405                 1410             


Ser Asp  Glu Val Asp Glu Gln  Val Ala Cys Gln Glu  Val Lys Val 
    1415                 1420                 1425             


Ser Val  Ala Ile Glu Asp Leu  Glu Pro Glu Asn Gly  Ile Leu Glu 
    1430                 1435                 1440             


Leu Glu  Xaa Lys Ser Ser Lys  Leu Val Gln Asn Ile  Ile Gln Xaa 
    1445                 1450                 1455             


Ala Val  Asp Gln Phe Val Arg  Xaa Glu Glu Xaa Ala  Xaa Glu Met 
    1460                 1465                 1470             


Leu Xaa  Ser Glu Leu Gln Xaa  Gln Ala His Val Ile  Lys Ala Asp 
    1475                 1480                 1485             


Ser Gln  Asp Ala Gly Gln Glu  Xaa Glu Lys Glu Gly  Glu Glu Pro 
    1490                 1495                 1500             


Gln Ala  Ser Ala Gln Asp Glu  Xaa Pro Ile Xaa Ser  Ala Lys Glu 
    1505                 1510                 1515             


Glu Ser  Glu Ser Xaa Ala Val  Gly Gln Ala His Ser  Asp Ile Ser 
    1520                 1525                 1530             


Lys Asp  Met Ser Glu Ala Ser  Glu Lys Xaa Met Xaa  Val Glu Val 
    1535                 1540                 1545             


Glu Gly  Ser Xaa Val Asn Asp  Gln Gln Leu Glu Glu  Val Val Leu 
    1550                 1555                 1560             


Pro Ser  Glu Glu Glu Gly Gly  Gly Ala Gly Xaa Lys  Ser Val Pro 
    1565                 1570                 1575             


Glu Asp  Asp Gly His Ala Leu  Leu Ala Glu Arg Ile  Glu Lys Ser 
    1580                 1585                 1590             


Leu Val  Glu Pro Lys Glu Asp  Glu Lys Gly Asp Asp  Val Asp Asp 
    1595                 1600                 1605             


Pro Glu  Asn Gln Asn Ser Ala  Leu Ala Asp Xaa Asp  Ala Ser Gly 
    1610                 1615                 1620             


Gly Leu  Xaa Lys Glu Ser Pro  Asp Xaa Asn Gly Pro  Lys Gln Lys 
    1625                 1630                 1635             


Glu Lys  Glu Asp Ala Gln Glu  Val Glu Leu Gln Glu  Gly Lys Val 
    1640                 1645                 1650             


His Ser  Glu Ser Asp Lys Ala  Ile Xaa Pro Gln Ala  Gln Glu Glu 
    1655                 1660                 1665             


Leu Gln  Lys Gln Glu Arg Glu  Ser Ala Lys Ser Glu  Leu Xaa Glu 
    1670                 1675                 1680             


Ser 
    


<210> 2085
<211> 1677
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1066)..(1066)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1128)..(1128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1195)..(1195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1246)..(1246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1260)..(1260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1272)..(1272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1315)..(1315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1317)..(1317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1338)..(1338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1379)..(1379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1386)..(1387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1400)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1439)..(1439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1451)..(1451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1459)..(1459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1462)..(1462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1464)..(1464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1489)..(1489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1504)..(1504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1507)..(1507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1516)..(1516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1536)..(1536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1538)..(1538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1567)..(1567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1612)..(1612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1619)..(1619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1625)..(1625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1655)..(1655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1675)..(1675)
<223> Selenocysteine

<400> 2085
Met Val Gly Gln Arg Asp Ser Glu Asp Val Ser Lys Arg Asp Ser Asp 
1               5                   10                  15      


Lys Glu Met Ala Xaa Lys Ser Ala Val Val His Asp Ile Xaa Asp Asp 
            20                  25                  30          


Gly Gln Glu Glu Xaa Pro Glu Ile Ile Glu Gln Ile Pro Ser Ser Glu 
        35                  40                  45              


Ser Asn Leu Glu Glu Leu Xaa Gln Pro Xaa Glu Ser Gln Ala Asn Asp 
    50                  55                  60                  


Ile Gly Phe Lys Lys Val Phe Lys Phe Val Gly Phe Lys Phe Xaa Val 
65                  70                  75                  80  


Lys Lys Asp Lys Xaa Glu Lys Pro Asp Xaa Val Gln Leu Leu Xaa Val 
                85                  90                  95      


Lys Lys Asp Glu Gly Glu Gly Ala Ala Gly Ala Gly Asp His Lys Asp 
            100                 105                 110         


Pro Ser Leu Gly Ala Gly Glu Ala Ala Ser Lys Glu Ser Glu Pro Lys 
        115                 120                 125             


Gln Ser Xaa Glu Lys Pro Glu Glu Xaa Leu Lys Arg Glu Gln Ser His 
    130                 135                 140                 


Ala Glu Ile Ser Pro Pro Ala Glu Ser Gly Gln Ala Val Glu Glu Cys 
145                 150                 155                 160 


Lys Glu Glu Gly Glu Glu Lys Gln Glu Lys Glu Pro Ser Lys Ser Ala 
                165                 170                 175     


Glu Ser Pro Xaa Ser Pro Val Xaa Ser Glu Xaa Gly Ser Xaa Phe Lys 
            180                 185                 190         


Lys Phe Phe Xaa Gln Gly Trp Ala Gly Trp Arg Lys Lys Xaa Ser Phe 
        195                 200                 205             


Arg Lys Pro Lys Glu Asp Glu Val Glu Ala Ser Glu Lys Lys Lys Glu 
    210                 215                 220                 


Gln Glu Pro Glu Lys Val Asp Xaa Glu Glu Asp Gly Lys Ala Glu Val 
225                 230                 235                 240 


Ala Ser Glu Lys Leu Xaa Ala Ser Glu Gln Ala His Pro Gln Glu Pro 
                245                 250                 255     


Ala Glu Ser Ala His Glu Pro Arg Leu Ser Ala Glu Tyr Glu Lys Val 
            260                 265                 270         


Glu Leu Pro Ser Glu Glu Gln Val Ser Gly Ser Gln Gly Pro Ser Glu 
        275                 280                 285             


Glu Lys Pro Ala Pro Leu Ala Xaa Glu Val Phe Asp Glu Lys Ile Glu 
    290                 295                 300                 


Val His Gln Glu Glu Val Val Ala Glu Val His Val Ser Xaa Val Glu 
305                 310                 315                 320 


Glu Arg Xaa Glu Glu Gln Lys Xaa Glu Val Glu Glu Xaa Ala Gly Ser 
                325                 330                 335     


Val Pro Ala Glu Glu Leu Val Glu Met Asp Ala Glu Pro Gln Glu Ala 
            340                 345                 350         


Glu Pro Ala Lys Glu Leu Val Lys Leu Lys Glu Xaa Cys Val Ser Gly 
        355                 360                 365             


Glu Asp Pro Xaa Gln Gly Ala Asp Leu Ser Pro Asp Glu Lys Val Leu 
    370                 375                 380                 


Ser Lys Pro Pro Glu Gly Val Val Ser Glu Val Glu Met Leu Ser Ser 
385                 390                 395                 400 


Gln Glu Arg Met Lys Val Gln Gly Ser Pro Leu Lys Lys Leu Phe Xaa 
                405                 410                 415     


Ser Xaa Gly Leu Lys Lys Leu Ser Gly Lys Lys Gln Lys Gly Lys Arg 
            420                 425                 430         


Gly Gly Gly Asp Glu Glu Ser Gly Glu His Xaa Gln Val Pro Ala Asp 
        435                 440                 445             


Ser Pro Asp Ser Gln Glu Glu Gln Lys Gly Glu Ser Ser Ala Ser Ser 
    450                 455                 460                 


Pro Glu Glu Pro Glu Glu Ile Xaa Cys Leu Glu Lys Gly Leu Ala Glu 
465                 470                 475                 480 


Val Gln Gln Asp Gly Glu Ala Glu Glu Gly Ala Xaa Ser Asp Gly Glu 
                485                 490                 495     


Lys Lys Arg Glu Gly Val Xaa Pro Trp Ala Ser Phe Lys Lys Met Val 
            500                 505                 510         


Xaa Pro Lys Lys Arg Val Arg Arg Pro Ser Glu Ser Asp Lys Glu Asp 
        515                 520                 525             


Glu Leu Asp Lys Val Lys Ser Ala Xaa Leu Ser Ser Xaa Glu Ser Xaa 
    530                 535                 540                 


Ala Ser Glu Met Gln Glu Glu Met Lys Gly Ser Val Glu Glu Pro Lys 
545                 550                 555                 560 


Pro Glu Glu Pro Lys Arg Lys Val Asp Xaa Ser Val Ser Trp Glu Ala 
                565                 570                 575     


Leu Ile Cys Val Gly Ser Ser Lys Lys Arg Ala Arg Arg Gly Ser Ser 
            580                 585                 590         


Ser Asp Glu Glu Gly Gly Pro Lys Ala Met Gly Gly Asp His Gln Lys 
        595                 600                 605             


Ala Asp Glu Ala Gly Lys Asp Lys Glu Xaa Gly Xaa Asp Gly Ile Leu 
    610                 615                 620                 


Ala Gly Ser Gln Glu His Asp Pro Gly Gln Gly Ser Ser Ser Pro Glu 
625                 630                 635                 640 


Gln Ala Gly Ser Pro Xaa Glu Gly Glu Gly Val Ser Xaa Trp Glu Ser 
                645                 650                 655     


Phe Lys Arg Leu Val Xaa Pro Arg Lys Lys Ser Lys Ser Lys Leu Glu 
            660                 665                 670         


Glu Lys Ser Glu Asp Ser Ile Ala Gly Ser Gly Val Glu His Ser Xaa 
        675                 680                 685             


Pro Asp Xaa Glu Pro Gly Lys Glu Glu Ser Trp Val Ser Ile Lys Lys 
    690                 695                 700                 


Phe Ile Pro Gly Arg Arg Lys Lys Arg Pro Asp Gly Lys Gln Glu Gln 
705                 710                 715                 720 


Ala Pro Val Glu Asp Ala Gly Pro Xaa Gly Ala Asn Glu Asp Asp Ser 
                725                 730                 735     


Asp Val Pro Ala Val Val Pro Leu Ser Glu Tyr Asp Ala Val Glu Arg 
            740                 745                 750         


Glu Lys Met Glu Ala Gln Gln Ala Gln Lys Ser Ala Glu Gln Pro Glu 
        755                 760                 765             


Gln Lys Ala Ala Xaa Glu Val Ser Lys Glu Leu Ser Glu Ser Gln Val 
    770                 775                 780                 


His Met Met Ala Ala Ala Val Ala Asp Gly Xaa Arg Ala Ala Xaa Ile 
785                 790                 795                 800 


Ile Glu Glu Arg Ser Pro Ser Trp Ile Ser Ala Ser Val Xaa Glu Pro 
                805                 810                 815     


Leu Glu Gln Val Glu Ala Glu Ala Ala Leu Leu Xaa Glu Glu Val Leu 
            820                 825                 830         


Glu Arg Glu Val Ile Ala Glu Glu Glu Pro Pro Xaa Val Xaa Glu Pro 
        835                 840                 845             


Leu Pro Glu Asn Arg Glu Ala Arg Gly Asp Xaa Val Val Ser Glu Ala 
    850                 855                 860                 


Glu Leu Xaa Pro Glu Ala Val Xaa Ala Ala Glu Xaa Ala Gly Pro Leu 
865                 870                 875                 880 


Gly Ala Glu Glu Gly Xaa Glu Ala Ser Ala Ala Glu Glu Xaa Xaa Glu 
                885                 890                 895     


Met Val Ser Ala Val Ser Gln Leu Xaa Asp Ser Pro Asp Xaa Xaa Glu 
            900                 905                 910         


Glu Ala Xaa Pro Val Gln Glu Val Glu Gly Gly Val Pro Asp Ile Glu 
        915                 920                 925             


Glu Gln Glu Arg Arg Xaa Gln Glu Val Leu Gln Ala Val Ala Glu Lys 
    930                 935                 940                 


Val Lys Glu Glu Ser Gln Leu Pro Gly Xaa Gly Gly Pro Glu Asp Val 
945                 950                 955                 960 


Leu Gln Pro Val Gln Arg Ala Glu Ala Glu Arg Pro Glu Glu Gln Ala 
                965                 970                 975     


Glu Ala Ser Gly Leu Lys Lys Glu Xaa Asp Val Val Leu Lys Val Asp 
            980                 985                 990         


Ala Gln Glu Ala Lys Xaa Glu Pro  Phe Xaa Gln Gly Lys  Val Val Gly 
        995                 1000                 1005             


Gln Xaa  Xaa Pro Glu Ser Phe  Glu Lys Ala Pro Gln  Val Xaa Glu 
    1010                 1015                 1020             


Ser Ile  Glu Ser Ser Glu Leu  Val Xaa Xaa Cys Gln  Ala Glu Xaa 
    1025                 1030                 1035             


Leu Ala  Gly Val Lys Ser Gln  Glu Met Val Met Glu  Gln Ala Ile 
    1040                 1045                 1050             


Pro Pro  Asp Ser Val Glu Xaa  Pro Xaa Asp Ser Glu  Xaa Asp Gly 
    1055                 1060                 1065             


Ser Xaa  Pro Val Ala Asp Phe  Asp Ala Pro Gly Xaa  Xaa Gln Lys 
    1070                 1075                 1080             


Asp Glu  Ile Val Glu Ile His  Glu Glu Asn Glu Val  Ala Ser Gly 
    1085                 1090                 1095             


Xaa Gln  Ser Gly Gly Xaa Glu  Ala Glu Ala Val Pro  Ala Gln Lys 
    1100                 1105                 1110             


Glu Arg  Pro Pro Ala Pro Ser  Ser Phe Val Phe Gln  Glu Glu Xaa 
    1115                 1120                 1125             


Lys Glu  Gln Ser Lys Met Glu  Asp Xaa Leu Glu His  Xaa Asp Lys 
    1130                 1135                 1140             


Glu Val  Ser Val Glu Xaa Val  Ser Ile Leu Ser Lys  Xaa Glu Gly 
    1145                 1150                 1155             


Xaa Gln  Glu Ala Asp Gln Tyr  Ala Asp Glu Lys Xaa  Lys Asp Val 
    1160                 1165                 1170             


Pro Phe  Phe Glu Gly Leu Glu  Gly Ser Ile Asp Xaa  Gly Ile Xaa 
    1175                 1180                 1185             


Val Ser  Arg Glu Lys Val Xaa  Glu Val Ala Leu Lys  Gly Glu Gly 
    1190                 1195                 1200             


Xaa Glu  Glu Ala Glu Cys Lys  Lys Asp Asp Ala Leu  Glu Leu Gln 
    1205                 1210                 1215             


Ser His  Ala Lys Ser Pro Pro  Ser Pro Val Glu Arg  Glu Met Val 
    1220                 1225                 1230             


Val Gln  Val Glu Arg Glu Lys  Xaa Glu Ala Glu Pro  Xaa His Val 
    1235                 1240                 1245             


Asn Glu  Glu Lys Leu Glu His  Glu Xaa Ala Val Xaa  Val Ser Glu 
    1250                 1255                 1260             


Glu Val  Ser Lys Gln Leu Leu  Gln Xaa Val Asn Val  Pro Ile Ile 
    1265                 1270                 1275             


Asp Gly  Ala Lys Glu Val Ser  Ser Leu Glu Gly Ser  Pro Pro Pro 
    1280                 1285                 1290             


Cys Leu  Gly Gln Glu Glu Ala  Val Cys Xaa Lys Ile  Gln Val Gln 
    1295                 1300                 1305             


Ser Ser  Glu Ala Ser Phe Xaa  Leu Xaa Ala Ala Ala  Glu Glu Glu 
    1310                 1315                 1320             


Lys Val  Leu Gly Glu Xaa Ala  Asn Ile Leu Glu Xaa  Gly Glu Xaa 
    1325                 1330                 1335             


Leu Glu  Pro Ala Gly Ala His  Leu Val Leu Glu Glu  Lys Ser Ser 
    1340                 1345                 1350             


Glu Lys  Asn Glu Asp Phe Ala  Ala His Pro Gly Glu  Asp Ala Val 
    1355                 1360                 1365             


Pro Xaa  Gly Pro Asp Cys Gln  Ala Lys Ser Xaa Pro  Val Ile Val 
    1370                 1375                 1380             


Ser Ala  Xaa Xaa Lys Lys Gly  Leu Ser Ser Asp Leu  Glu Gly Glu 
    1385                 1390                 1395             


Lys Xaa  Xaa Ser Leu Lys Trp  Lys Ser Asp Glu Val  Asp Glu Gln 
    1400                 1405                 1410             


Val Ala  Cys Gln Glu Val Lys  Val Ser Val Ala Ile  Glu Asp Leu 
    1415                 1420                 1425             


Glu Pro  Glu Asn Gly Ile Leu  Glu Leu Glu Xaa Lys  Ser Ser Lys 
    1430                 1435                 1440             


Leu Val  Gln Asn Ile Ile Gln  Xaa Ala Val Asp Gln  Phe Val Arg 
    1445                 1450                 1455             


Xaa Glu  Glu Xaa Ala Xaa Glu  Met Leu Xaa Ser Glu  Leu Gln Xaa 
    1460                 1465                 1470             


Gln Ala  His Val Ile Lys Ala  Asp Ser Gln Asp Ala  Gly Gln Glu 
    1475                 1480                 1485             


Xaa Glu  Lys Glu Gly Glu Glu  Pro Gln Ala Ser Ala  Gln Asp Glu 
    1490                 1495                 1500             


Xaa Pro  Ile Xaa Ser Ala Lys  Glu Glu Ser Glu Ser  Xaa Ala Val 
    1505                 1510                 1515             


Gly Gln  Ala His Ser Asp Ile  Ser Lys Asp Met Ser  Glu Ala Ser 
    1520                 1525                 1530             


Glu Lys  Xaa Met Xaa Val Glu  Val Glu Gly Ser Xaa  Val Asn Asp 
    1535                 1540                 1545             


Gln Gln  Leu Glu Glu Val Val  Leu Pro Ser Glu Glu  Glu Gly Gly 
    1550                 1555                 1560             


Gly Ala  Gly Xaa Lys Ser Val  Pro Glu Asp Asp Gly  His Ala Leu 
    1565                 1570                 1575             


Leu Ala  Glu Arg Ile Glu Lys  Ser Leu Val Glu Pro  Lys Glu Asp 
    1580                 1585                 1590             


Glu Lys  Gly Asp Asp Val Asp  Asp Pro Glu Asn Gln  Asn Ser Ala 
    1595                 1600                 1605             


Leu Ala  Asp Xaa Asp Ala Ser  Gly Gly Leu Xaa Lys  Glu Ser Pro 
    1610                 1615                 1620             


Asp Xaa  Asn Gly Pro Lys Gln  Lys Glu Lys Glu Asp  Ala Gln Glu 
    1625                 1630                 1635             


Val Glu  Leu Gln Glu Gly Lys  Val His Ser Glu Ser  Asp Lys Ala 
    1640                 1645                 1650             


Ile Xaa  Pro Gln Ala Gln Glu  Glu Leu Gln Lys Gln  Glu Arg Glu 
    1655                 1660                 1665             


Ser Ala  Lys Ser Glu Leu Xaa  Glu Ser 
    1670                 1675         


<210> 2086
<211> 146
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<400> 2086
Met Gly Leu Arg Tyr Ser Gly Cys Leu Gly Ser His Val Glu Asn Ala 
1               5                   10                  15      


Gly Glu Pro Asp Ser Trp Ser Ser Leu Ser Tyr Glu Ile Pro Tyr Gly 
            20                  25                  30          


Asp Cys Ser Val Arg His His Arg Glu Leu Asp Ile Tyr Xaa Leu Xaa 
        35                  40                  45              


Ser Glu Ser Asp Ser His His Glu His Pro Phe Pro Gly Asp Gly Cys 
    50                  55                  60                  


Xaa Gly Pro Ile Phe Lys Leu Met Asn Ile Gln Gln Gln Leu Met Lys 
65                  70                  75                  80  


Xaa Asn Leu Lys Gln Met Asp Ser Leu Met Pro Leu Met Met Xaa Ala 
                85                  90                  95      


Gln Asp Pro Ser Ser Ala Pro Glu Xaa Asp Gly Gln Phe Leu Pro Cys 
            100                 105                 110         


Ala Pro Glu Pro Xaa Asp Pro Gln Arg Leu Ser Ser Ser Glu Glu Xaa 
        115                 120                 125             


Glu Ser Xaa Gln Cys Cys Pro Gly Ser Pro Val Ala Gln Xaa Glu Ser 
    130                 135                 140                 


Pro Cys 
145     


<210> 2087
<211> 38
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<400> 2087
Met Lys Leu Asn Pro Gln Gln Ala Pro Leu Tyr Gly Asp Cys Val Val 
1               5                   10                  15      


Xaa Val Leu Leu Ala Glu Glu Asp Lys Ala Glu Asp Asp Val Val Phe 
            20                  25                  30          


Tyr Leu Val Phe Leu Gly 
        35              


<210> 2088
<211> 1745
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1197)..(1197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1297)..(1297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1314)..(1314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1319)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1395)..(1395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1469)..(1469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1475)..(1475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1478)..(1478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1589)..(1589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1660)..(1660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1668)..(1668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1675)..(1675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1690)..(1690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1694)..(1694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1699)..(1699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1703)..(1703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1725)..(1725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1730)..(1730)
<223> Selenocysteine

<400> 2088
Met Lys Leu Asn Pro Gln Gln Ala Pro Leu Tyr Gly Asp Cys Val Val 
1               5                   10                  15      


Xaa Val Leu Leu Ala Glu Glu Asp Lys Ala Glu Asp Asp Val Val Phe 
            20                  25                  30          


Tyr Leu Val Phe Leu Gly Ser Xaa Leu Arg His Cys Xaa Ser Xaa Arg 
        35                  40                  45              


Lys Val Ser Ser Asp Xaa Leu Glu Xaa Ile Ala Pro Gly His Asp Cys 
    50                  55                  60                  


Cys Glu Xaa Val Lys Val Gln Leu Cys Ala Ser Lys Glu Gly Leu Pro 
65                  70                  75                  80  


Val Phe Val Val Ala Glu Glu Asp Phe His Phe Val Gln Asp Glu Ala 
                85                  90                  95      


Tyr Asp Ala Ala Gln Phe Leu Ala Xaa Ser Ala Gly Asn Gln Gln Ala 
            100                 105                 110         


Leu Asn Phe Xaa Arg Phe Leu Asp Gln Ser Gly Pro Pro Ser Gly Asp 
        115                 120                 125             


Val Asn Ser Leu Asp Lys Lys Leu Val Leu Ala Phe Arg His Leu Lys 
    130                 135                 140                 


Leu Pro Xaa Glu Trp Asn Val Leu Gly Xaa Asp Gln Ser Leu His Asp 
145                 150                 155                 160 


Ala Gly Pro Arg Glu Xaa Leu Met His Phe Ala Val Arg Leu Gly Leu 
                165                 170                 175     


Leu Arg Leu Xaa Trp Phe Leu Leu Gln Lys Pro Gly Gly Arg Gly Ala 
            180                 185                 190         


Leu Ser Ile His Asn Gln Glu Gly Ala Xaa Pro Val Ser Leu Ala Leu 
        195                 200                 205             


Glu Arg Gly Tyr His Lys Leu His Gln Leu Leu Xaa Glu Glu Asn Ala 
    210                 215                 220                 


Gly Glu Pro Asp Ser Trp Ser Ser Leu Ser Tyr Glu Ile Pro Tyr Gly 
225                 230                 235                 240 


Asp Cys Ser Val Arg His His Arg Glu Leu Asp Ile Tyr Xaa Leu Xaa 
                245                 250                 255     


Ser Glu Ser Asp Ser His His Glu His Pro Phe Pro Gly Asp Gly Cys 
            260                 265                 270         


Xaa Gly Pro Ile Phe Lys Leu Met Asn Ile Gln Gln Gln Leu Met Lys 
        275                 280                 285             


Xaa Asn Leu Lys Gln Met Asp Ser Leu Met Pro Leu Met Met Xaa Ala 
    290                 295                 300                 


Gln Asp Pro Ser Ser Ala Pro Glu Xaa Asp Gly Gln Phe Leu Pro Cys 
305                 310                 315                 320 


Ala Pro Glu Pro Xaa Asp Pro Gln Arg Leu Ser Ser Ser Glu Glu Xaa 
                325                 330                 335     


Glu Ser Xaa Gln Cys Cys Pro Gly Ser Pro Val Ala Gln Xaa Glu Ser 
            340                 345                 350         


Pro Cys Asp Leu Ser Ser Ile Val Glu Glu Glu Asn Xaa Asp Arg Ser 
        355                 360                 365             


Cys Arg Lys Lys Asn Lys Gly Val Glu Arg Lys Gly Glu Glu Val Glu 
    370                 375                 380                 


Pro Ala Pro Ile Val Asp Ser Gly Xaa Val Ser Asp Gln Asp Ser Cys 
385                 390                 395                 400 


Leu Gln Ser Leu Pro Asp Cys Gly Val Lys Gly Xaa Glu Gly Leu Ser 
                405                 410                 415     


Ser Cys Gly Asn Arg Asn Glu Glu Xaa Gly Xaa Lys Ser Ser Gly Met 
            420                 425                 430         


Pro Xaa Asp Gln Glu Ser Leu Ser Ser Gly Asp Ala Val Leu Gln Arg 
        435                 440                 445             


Asp Leu Val Met Glu Pro Gly Xaa Ala Gln Tyr Ser Ser Gly Gly Glu 
    450                 455                 460                 


Leu Gly Gly Ile Ser Xaa Xaa Asn Val Ser Xaa Pro Asp Xaa Ala Gly 
465                 470                 475                 480 


Glu Met Glu His Gly Leu Met Asn Pro Asp Ala Xaa Val Trp Lys Asn 
                485                 490                 495     


Val Leu Gln Gly Gly Glu Ser Xaa Lys Glu Arg Phe Glu Asn Ser Asn 
            500                 505                 510         


Ile Gly Xaa Ala Gly Ala Ser Asp Val His Val Xaa Ser Lys Pro Val 
        515                 520                 525             


Asp Lys Ile Ser Val Pro Asn Cys Ala Pro Ala Ala Ser Ser Leu Asp 
    530                 535                 540                 


Gly Asn Lys Pro Ala Glu Ser Ser Leu Ala Phe Ser Asn Glu Glu Xaa 
545                 550                 555                 560 


Ser Xaa Glu Lys Xaa Ala Glu Xaa Glu Xaa Ser Arg Ser Arg Glu Glu 
                565                 570                 575     


Ser Ala Asp Ala Pro Val Asp Gln Asn Ser Val Val Ile Pro Ala Ala 
            580                 585                 590         


Ala Lys Asp Lys Ile Ser Asp Gly Leu Glu Pro Tyr Xaa Leu Leu Ala 
        595                 600                 605             


Ala Gly Ile Gly Glu Ala Met Ser Pro Ser Asp Leu Ala Leu Leu Gly 
    610                 615                 620                 


Leu Glu Glu Asp Val Met Pro His Gln Asn Ser Glu Xaa Asn Ser Ser 
625                 630                 635                 640 


His Ala Gln Ser Gln Lys Gly Lys Ser Ser Pro Ile Cys Ser Xaa Xaa 
                645                 650                 655     


Gly Asp Asp Lys Leu Cys Ala Asp Ser Ala Cys Gln Gln Asn Xaa Val 
            660                 665                 670         


Xaa Ser Ser Gly Asp Leu Val Ala Lys Leu Cys Asp Asn Ile Val Ser 
        675                 680                 685             


Glu Ser Glu Ser Xaa Xaa Ala Arg Gln Pro Ser Ser Gln Asp Pro Pro 
    690                 695                 700                 


Asp Ala Ser His Cys Glu Asp Pro Gln Ala His Xaa Val Xaa Ser Asp 
705                 710                 715                 720 


Pro Val Arg Asp Xaa Gln Glu Arg Ala Asp Phe Cys Pro Phe Lys Val 
                725                 730                 735     


Val Asp Asn Lys Gly Gln Arg Lys Asp Val Lys Leu Asp Lys Pro Leu 
            740                 745                 750         


Xaa Asn Met Leu Glu Val Val Ser His Pro His Pro Val Val Pro Lys 
        755                 760                 765             


Met Glu Lys Glu Leu Val Pro Asp Gln Ala Val Ile Ser Asp Ser Xaa 
    770                 775                 780                 


Phe Ser Leu Ala Asn Ser Pro Gly Ser Glu Ser Val Xaa Lys Asp Asp 
785                 790                 795                 800 


Ala Leu Ser Phe Val Pro Ser Gln Lys Glu Lys Gly Xaa Ala Xaa Pro 
                805                 810                 815     


Glu Leu His Xaa Ala Xaa Asp Tyr Arg Asp Gly Pro Asp Gly Asn Ser 
            820                 825                 830         


Asn Glu Pro Asp Xaa Arg Pro Leu Glu Asp Arg Ala Val Gly Leu Ser 
        835                 840                 845             


Xaa Ser Ser Xaa Ala Ala Glu Leu Gln His Gly Met Gly Asn Xaa Ser 
    850                 855                 860                 


Leu Xaa Gly Leu Gly Gly Glu His Glu Gly Pro Ala Pro Pro Ala Ile 
865                 870                 875                 880 


Pro Glu Ala Leu Asn Ile Lys Gly Asn Xaa Asp Ser Ser Leu Gln Ser 
                885                 890                 895     


Val Gly Lys Ala Xaa Leu Ala Leu Asp Ser Val Leu Xaa Glu Glu Gly 
            900                 905                 910         


Lys Leu Leu Val Val Ser Glu Ser Ser Ala Ala Gln Glu Gln Asp Lys 
        915                 920                 925             


Asp Lys Ala Val Xaa Cys Ser Ser Ile Lys Glu Asn Ala Leu Ser Ser 
    930                 935                 940                 


Gly Xaa Leu Gln Glu Glu Gln Arg Xaa Pro Pro Pro Gly Gln Asp Xaa 
945                 950                 955                 960 


Gln Gln Phe His Glu Lys Ser Ile Ser Ala Asp Cys Ala Lys Asp Lys 
                965                 970                 975     


Ala Leu Gln Leu Ser Asn Ser Pro Gly Ala Ser Ser Ala Phe Leu Lys 
            980                 985                 990         


Ala Glu Xaa Glu His Asn Lys Glu  Val Ala Pro Gln Val  Ser Leu Leu 
        995                 1000                 1005             


Xaa Gln  Gly Gly Ala Ala Gln  Ser Leu Val Pro Pro  Gly Ala Ser 
    1010                 1015                 1020             


Leu Ala  Xaa Glu Ser Arg Gln  Glu Ala Leu Gly Ala  Glu His Asn 
    1025                 1030                 1035             


Ser Ser  Ala Leu Leu Pro Cys  Leu Leu Pro Asp Gly  Ser Asp Gly 
    1040                 1045                 1050             


Ser Asp  Ala Leu Asn Cys Ser  Gln Pro Ser Pro Leu  Asp Val Gly 
    1055                 1060                 1065             


Val Lys  Asn Xaa Gln Ser Gln  Gly Lys Xaa Ser Ala  Cys Glu Val 
    1070                 1075                 1080             


Ser Gly  Asp Val Xaa Val Asp  Val Xaa Gly Val Asn  Ala Leu Gln 
    1085                 1090                 1095             


Gly Met  Ala Glu Pro Arg Arg  Glu Asn Ile Ser His  Asn Xaa Gln 
    1100                 1105                 1110             


Asp Ile  Leu Ile Pro Asn Val  Leu Leu Ser Gln Glu  Lys Asn Ala 
    1115                 1120                 1125             


Val Leu  Gly Leu Pro Val Ala  Leu Gln Asp Lys Ala  Val Xaa Asp 
    1130                 1135                 1140             


Pro Gln  Gly Val Gly Xaa Pro  Glu Met Ile Pro Leu  Asp Trp Glu 
    1145                 1150                 1155             


Lys Gly  Lys Leu Glu Gly Ala  Asp His Ser Cys Xaa  Met Gly Asp 
    1160                 1165                 1170             


Ala Glu  Glu Ala Gln Ile Asp  Asp Glu Ala His Pro  Val Leu Leu 
    1175                 1180                 1185             


Gln Pro  Val Ala Lys Glu Leu  Pro Xaa Asp Met Glu  Leu Ser Ala 
    1190                 1195                 1200             


His Asp  Asp Gly Ala Pro Ala  Gly Val Arg Glu Val  Met Arg Ala 
    1205                 1210                 1215             


Pro Pro  Ser Gly Arg Glu Arg  Ser Xaa Pro Ser Leu  Pro Cys Met 
    1220                 1225                 1230             


Val Ser  Ala Gln Asp Ala Pro  Leu Pro Lys Gly Ala  Asp Leu Ile 
    1235                 1240                 1245             


Glu Glu  Ala Ala Ser Arg Ile  Val Asp Ala Val Ile  Glu Gln Val 
    1250                 1255                 1260             


Lys Ala  Ala Gly Ala Leu Leu  Xaa Glu Gly Glu Ala  Cys His Met 
    1265                 1270                 1275             


Ser Leu  Ser Ser Pro Glu Leu  Gly Pro Leu Xaa Lys  Gly Leu Glu 
    1280                 1285                 1290             


Ser Ala  Phe Xaa Glu Lys Val  Ser Xaa Phe Pro Pro  Gly Glu Ser 
    1295                 1300                 1305             


Leu Pro  Met Gly Ser Xaa Pro  Glu Glu Ala Xaa Gly  Ser Leu Ala 
    1310                 1315                 1320             


Gly Cys  Phe Ala Gly Arg Glu  Glu Pro Glu Lys Ile  Ile Leu Pro 
    1325                 1330                 1335             


Val Gln  Gly Pro Glu Pro Ala  Ala Glu Met Pro Asp  Val Lys Ala 
    1340                 1345                 1350             


Glu Asp  Glu Val Asp Phe Arg  Ala Ser Ser Ile Ser  Glu Glu Val 
    1355                 1360                 1365             


Ala Val  Gly Ser Ile Ala Ala  Xaa Leu Lys Met Lys  Gln Gly Pro 
    1370                 1375                 1380             


Met Xaa  Gln Ala Ile Asn Arg  Glu Asn Trp Cys Xaa  Ile Glu Pro 
    1385                 1390                 1395             


Cys Pro  Asp Ala Ala Ser Leu  Leu Ala Ser Lys Gln  Ser Pro Glu 
    1400                 1405                 1410             


Cys Glu  Asn Phe Leu Asp Val  Gly Leu Gly Arg Glu  Cys Xaa Ser 
    1415                 1420                 1425             


Lys Gln  Gly Val Leu Lys Arg  Glu Ser Gly Ser Asp  Ser Asp Leu 
    1430                 1435                 1440             


Phe His  Ser Pro Ser Asp Asp  Met Asp Ser Ile Ile  Phe Pro Lys 
    1445                 1450                 1455             


Pro Glu  Glu Glu His Leu Ala  Cys Asp Ile Xaa Gly  Ser Ser Ser 
    1460                 1465                 1470             


Ser Xaa  Asp Asp Xaa Ala Ser  Leu Asp Arg His Ser  Ser His Gly 
    1475                 1480                 1485             


Ser Asp  Val Ser Leu Ser Gln  Ile Leu Lys Pro Asn  Arg Ser Arg 
    1490                 1495                 1500             


Asp Arg  Gln Ser Leu Asp Gly  Phe Tyr Ser His Gly  Met Gly Ala 
    1505                 1510                 1515             


Glu Gly  Arg Glu Ser Glu Ser  Glu Pro Ala Asp Pro  Gly Asp Val 
    1520                 1525                 1530             


Glu Glu  Glu Glu Met Asp Ser  Ile Xaa Glu Val Pro  Ala Asn Cys 
    1535                 1540                 1545             


Ser Val  Leu Arg Ser Ser Met  Arg Ser Leu Ser Pro  Phe Arg Arg 
    1550                 1555                 1560             


His Ser  Trp Gly Pro Gly Lys  Asn Ala Ala Ser Asp  Ala Glu Met 
    1565                 1570                 1575             


Asn His  Arg Ser Phe Ser Leu  Glu Gly Leu Xaa Gly  Gly Ala Gly 
    1580                 1585                 1590             


Val Gly  Asn Lys Pro Ser Ser  Ser Leu Glu Val Ser  Ser Ala Asn 
    1595                 1600                 1605             


Ala Glu  Glu Leu Arg His Pro  Phe Ser Gly Glu Glu  Arg Val Asp 
    1610                 1615                 1620             


Ser Leu  Val Ser Leu Ser Glu  Glu Asp Leu Glu Ser  Asp Gln Arg 
    1625                 1630                 1635             


Glu His  Arg Met Phe Asp Gln  Gln Ile Cys His Arg  Ser Lys Gln 
    1640                 1645                 1650             


Gln Gly  Phe Asn Tyr Cys Xaa  Ser Ala Ile Ser Ser  Pro Leu Xaa 
    1655                 1660                 1665             


Lys Ser  Ile Ser Leu Met Xaa  Ile Ser His Pro Gly  Leu Asp Asn 
    1670                 1675                 1680             


Ser Arg  Pro Phe His Ser Xaa  Phe His Asn Xaa Ser  Ala Asn Leu 
    1685                 1690                 1695             


Xaa Glu  Ser Ile Xaa Glu Glu  Asn Tyr Asn Phe Leu  Pro His Ser 
    1700                 1705                 1710             


Pro Ser  Lys Lys Asp Ser Glu  Trp Lys Ser Gly Xaa  Lys Val Ser 
    1715                 1720                 1725             


Arg Xaa  Phe Ser Tyr Ile Lys  Asn Lys Met Ser Ser  Ser Lys Lys 
    1730                 1735                 1740             


Ser Lys  
    1745 


<210> 2089
<211> 2813
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1197)..(1197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1297)..(1297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1314)..(1314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1319)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1395)..(1395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1469)..(1469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1475)..(1475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1478)..(1478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1678)..(1678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1686)..(1686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1693)..(1693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1708)..(1708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1712)..(1712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1717)..(1717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1743)..(1743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1748)..(1748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1788)..(1788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1793)..(1793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1813)..(1813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1819)..(1819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1855)..(1855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1860)..(1860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1884)..(1884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1886)..(1887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1911)..(1911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1922)..(1922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1930)..(1930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1943)..(1943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1947)..(1947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1953)..(1953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2005)..(2005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2012)..(2012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2096)..(2096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2147)..(2147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2151)..(2151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2164)..(2164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2206)..(2206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2208)..(2208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2256)..(2256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2279)..(2279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2306)..(2306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2331)..(2331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2334)..(2334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2356)..(2356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2391)..(2391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2400)..(2400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2411)..(2411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2442)..(2442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2446)..(2446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2467)..(2467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2496)..(2496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2559)..(2559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2646)..(2646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2680)..(2680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2692)..(2692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2737)..(2737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2750)..(2750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2753)..(2753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2767)..(2767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2771)..(2771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2777)..(2777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2791)..(2791)
<223> Selenocysteine

<400> 2089
Met Lys Leu Asn Pro Gln Gln Ala Pro Leu Tyr Gly Asp Cys Val Val 
1               5                   10                  15      


Xaa Val Leu Leu Ala Glu Glu Asp Lys Ala Glu Asp Asp Val Val Phe 
            20                  25                  30          


Tyr Leu Val Phe Leu Gly Ser Xaa Leu Arg His Cys Xaa Ser Xaa Arg 
        35                  40                  45              


Lys Val Ser Ser Asp Xaa Leu Glu Xaa Ile Ala Pro Gly His Asp Cys 
    50                  55                  60                  


Cys Glu Xaa Val Lys Val Gln Leu Cys Ala Ser Lys Glu Gly Leu Pro 
65                  70                  75                  80  


Val Phe Val Val Ala Glu Glu Asp Phe His Phe Val Gln Asp Glu Ala 
                85                  90                  95      


Tyr Asp Ala Ala Gln Phe Leu Ala Xaa Ser Ala Gly Asn Gln Gln Ala 
            100                 105                 110         


Leu Asn Phe Xaa Arg Phe Leu Asp Gln Ser Gly Pro Pro Ser Gly Asp 
        115                 120                 125             


Val Asn Ser Leu Asp Lys Lys Leu Val Leu Ala Phe Arg His Leu Lys 
    130                 135                 140                 


Leu Pro Xaa Glu Trp Asn Val Leu Gly Xaa Asp Gln Ser Leu His Asp 
145                 150                 155                 160 


Ala Gly Pro Arg Glu Xaa Leu Met His Phe Ala Val Arg Leu Gly Leu 
                165                 170                 175     


Leu Arg Leu Xaa Trp Phe Leu Leu Gln Lys Pro Gly Gly Arg Gly Ala 
            180                 185                 190         


Leu Ser Ile His Asn Gln Glu Gly Ala Xaa Pro Val Ser Leu Ala Leu 
        195                 200                 205             


Glu Arg Gly Tyr His Lys Leu His Gln Leu Leu Xaa Glu Glu Asn Ala 
    210                 215                 220                 


Gly Glu Pro Asp Ser Trp Ser Ser Leu Ser Tyr Glu Ile Pro Tyr Gly 
225                 230                 235                 240 


Asp Cys Ser Val Arg His His Arg Glu Leu Asp Ile Tyr Xaa Leu Xaa 
                245                 250                 255     


Ser Glu Ser Asp Ser His His Glu His Pro Phe Pro Gly Asp Gly Cys 
            260                 265                 270         


Xaa Gly Pro Ile Phe Lys Leu Met Asn Ile Gln Gln Gln Leu Met Lys 
        275                 280                 285             


Xaa Asn Leu Lys Gln Met Asp Ser Leu Met Pro Leu Met Met Xaa Ala 
    290                 295                 300                 


Gln Asp Pro Ser Ser Ala Pro Glu Xaa Asp Gly Gln Phe Leu Pro Cys 
305                 310                 315                 320 


Ala Pro Glu Pro Xaa Asp Pro Gln Arg Leu Ser Ser Ser Glu Glu Xaa 
                325                 330                 335     


Glu Ser Xaa Gln Cys Cys Pro Gly Ser Pro Val Ala Gln Xaa Glu Ser 
            340                 345                 350         


Pro Cys Asp Leu Ser Ser Ile Val Glu Glu Glu Asn Xaa Asp Arg Ser 
        355                 360                 365             


Cys Arg Lys Lys Asn Lys Gly Val Glu Arg Lys Gly Glu Glu Val Glu 
    370                 375                 380                 


Pro Ala Pro Ile Val Asp Ser Gly Xaa Val Ser Asp Gln Asp Ser Cys 
385                 390                 395                 400 


Leu Gln Ser Leu Pro Asp Cys Gly Val Lys Gly Xaa Glu Gly Leu Ser 
                405                 410                 415     


Ser Cys Gly Asn Arg Asn Glu Glu Xaa Gly Xaa Lys Ser Ser Gly Met 
            420                 425                 430         


Pro Xaa Asp Gln Glu Ser Leu Ser Ser Gly Asp Ala Val Leu Gln Arg 
        435                 440                 445             


Asp Leu Val Met Glu Pro Gly Xaa Ala Gln Tyr Ser Ser Gly Gly Glu 
    450                 455                 460                 


Leu Gly Gly Ile Ser Xaa Xaa Asn Val Ser Xaa Pro Asp Xaa Ala Gly 
465                 470                 475                 480 


Glu Met Glu His Gly Leu Met Asn Pro Asp Ala Xaa Val Trp Lys Asn 
                485                 490                 495     


Val Leu Gln Gly Gly Glu Ser Xaa Lys Glu Arg Phe Glu Asn Ser Asn 
            500                 505                 510         


Ile Gly Xaa Ala Gly Ala Ser Asp Val His Val Xaa Ser Lys Pro Val 
        515                 520                 525             


Asp Lys Ile Ser Val Pro Asn Cys Ala Pro Ala Ala Ser Ser Leu Asp 
    530                 535                 540                 


Gly Asn Lys Pro Ala Glu Ser Ser Leu Ala Phe Ser Asn Glu Glu Xaa 
545                 550                 555                 560 


Ser Xaa Glu Lys Xaa Ala Glu Xaa Glu Xaa Ser Arg Ser Arg Glu Glu 
                565                 570                 575     


Ser Ala Asp Ala Pro Val Asp Gln Asn Ser Val Val Ile Pro Ala Ala 
            580                 585                 590         


Ala Lys Asp Lys Ile Ser Asp Gly Leu Glu Pro Tyr Xaa Leu Leu Ala 
        595                 600                 605             


Ala Gly Ile Gly Glu Ala Met Ser Pro Ser Asp Leu Ala Leu Leu Gly 
    610                 615                 620                 


Leu Glu Glu Asp Val Met Pro His Gln Asn Ser Glu Xaa Asn Ser Ser 
625                 630                 635                 640 


His Ala Gln Ser Gln Lys Gly Lys Ser Ser Pro Ile Cys Ser Xaa Xaa 
                645                 650                 655     


Gly Asp Asp Lys Leu Cys Ala Asp Ser Ala Cys Gln Gln Asn Xaa Val 
            660                 665                 670         


Xaa Ser Ser Gly Asp Leu Val Ala Lys Leu Cys Asp Asn Ile Val Ser 
        675                 680                 685             


Glu Ser Glu Ser Xaa Xaa Ala Arg Gln Pro Ser Ser Gln Asp Pro Pro 
    690                 695                 700                 


Asp Ala Ser His Cys Glu Asp Pro Gln Ala His Xaa Val Xaa Ser Asp 
705                 710                 715                 720 


Pro Val Arg Asp Xaa Gln Glu Arg Ala Asp Phe Cys Pro Phe Lys Val 
                725                 730                 735     


Val Asp Asn Lys Gly Gln Arg Lys Asp Val Lys Leu Asp Lys Pro Leu 
            740                 745                 750         


Xaa Asn Met Leu Glu Val Val Ser His Pro His Pro Val Val Pro Lys 
        755                 760                 765             


Met Glu Lys Glu Leu Val Pro Asp Gln Ala Val Ile Ser Asp Ser Xaa 
    770                 775                 780                 


Phe Ser Leu Ala Asn Ser Pro Gly Ser Glu Ser Val Xaa Lys Asp Asp 
785                 790                 795                 800 


Ala Leu Ser Phe Val Pro Ser Gln Lys Glu Lys Gly Xaa Ala Xaa Pro 
                805                 810                 815     


Glu Leu His Xaa Ala Xaa Asp Tyr Arg Asp Gly Pro Asp Gly Asn Ser 
            820                 825                 830         


Asn Glu Pro Asp Xaa Arg Pro Leu Glu Asp Arg Ala Val Gly Leu Ser 
        835                 840                 845             


Xaa Ser Ser Xaa Ala Ala Glu Leu Gln His Gly Met Gly Asn Xaa Ser 
    850                 855                 860                 


Leu Xaa Gly Leu Gly Gly Glu His Glu Gly Pro Ala Pro Pro Ala Ile 
865                 870                 875                 880 


Pro Glu Ala Leu Asn Ile Lys Gly Asn Xaa Asp Ser Ser Leu Gln Ser 
                885                 890                 895     


Val Gly Lys Ala Xaa Leu Ala Leu Asp Ser Val Leu Xaa Glu Glu Gly 
            900                 905                 910         


Lys Leu Leu Val Val Ser Glu Ser Ser Ala Ala Gln Glu Gln Asp Lys 
        915                 920                 925             


Asp Lys Ala Val Xaa Cys Ser Ser Ile Lys Glu Asn Ala Leu Ser Ser 
    930                 935                 940                 


Gly Xaa Leu Gln Glu Glu Gln Arg Xaa Pro Pro Pro Gly Gln Asp Xaa 
945                 950                 955                 960 


Gln Gln Phe His Glu Lys Ser Ile Ser Ala Asp Cys Ala Lys Asp Lys 
                965                 970                 975     


Ala Leu Gln Leu Ser Asn Ser Pro Gly Ala Ser Ser Ala Phe Leu Lys 
            980                 985                 990         


Ala Glu Xaa Glu His Asn Lys Glu  Val Ala Pro Gln Val  Ser Leu Leu 
        995                 1000                 1005             


Xaa Gln  Gly Gly Ala Ala Gln  Ser Leu Val Pro Pro  Gly Ala Ser 
    1010                 1015                 1020             


Leu Ala  Xaa Glu Ser Arg Gln  Glu Ala Leu Gly Ala  Glu His Asn 
    1025                 1030                 1035             


Ser Ser  Ala Leu Leu Pro Cys  Leu Leu Pro Asp Gly  Ser Asp Gly 
    1040                 1045                 1050             


Ser Asp  Ala Leu Asn Cys Ser  Gln Pro Ser Pro Leu  Asp Val Gly 
    1055                 1060                 1065             


Val Lys  Asn Xaa Gln Ser Gln  Gly Lys Xaa Ser Ala  Cys Glu Val 
    1070                 1075                 1080             


Ser Gly  Asp Val Xaa Val Asp  Val Xaa Gly Val Asn  Ala Leu Gln 
    1085                 1090                 1095             


Gly Met  Ala Glu Pro Arg Arg  Glu Asn Ile Ser His  Asn Xaa Gln 
    1100                 1105                 1110             


Asp Ile  Leu Ile Pro Asn Val  Leu Leu Ser Gln Glu  Lys Asn Ala 
    1115                 1120                 1125             


Val Leu  Gly Leu Pro Val Ala  Leu Gln Asp Lys Ala  Val Xaa Asp 
    1130                 1135                 1140             


Pro Gln  Gly Val Gly Xaa Pro  Glu Met Ile Pro Leu  Asp Trp Glu 
    1145                 1150                 1155             


Lys Gly  Lys Leu Glu Gly Ala  Asp His Ser Cys Xaa  Met Gly Asp 
    1160                 1165                 1170             


Ala Glu  Glu Ala Gln Ile Asp  Asp Glu Ala His Pro  Val Leu Leu 
    1175                 1180                 1185             


Gln Pro  Val Ala Lys Glu Leu  Pro Xaa Asp Met Glu  Leu Ser Ala 
    1190                 1195                 1200             


His Asp  Asp Gly Ala Pro Ala  Gly Val Arg Glu Val  Met Arg Ala 
    1205                 1210                 1215             


Pro Pro  Ser Gly Arg Glu Arg  Ser Xaa Pro Ser Leu  Pro Cys Met 
    1220                 1225                 1230             


Val Ser  Ala Gln Asp Ala Pro  Leu Pro Lys Gly Ala  Asp Leu Ile 
    1235                 1240                 1245             


Glu Glu  Ala Ala Ser Arg Ile  Val Asp Ala Val Ile  Glu Gln Val 
    1250                 1255                 1260             


Lys Ala  Ala Gly Ala Leu Leu  Xaa Glu Gly Glu Ala  Cys His Met 
    1265                 1270                 1275             


Ser Leu  Ser Ser Pro Glu Leu  Gly Pro Leu Xaa Lys  Gly Leu Glu 
    1280                 1285                 1290             


Ser Ala  Phe Xaa Glu Lys Val  Ser Xaa Phe Pro Pro  Gly Glu Ser 
    1295                 1300                 1305             


Leu Pro  Met Gly Ser Xaa Pro  Glu Glu Ala Xaa Gly  Ser Leu Ala 
    1310                 1315                 1320             


Gly Cys  Phe Ala Gly Arg Glu  Glu Pro Glu Lys Ile  Ile Leu Pro 
    1325                 1330                 1335             


Val Gln  Gly Pro Glu Pro Ala  Ala Glu Met Pro Asp  Val Lys Ala 
    1340                 1345                 1350             


Glu Asp  Glu Val Asp Phe Arg  Ala Ser Ser Ile Ser  Glu Glu Val 
    1355                 1360                 1365             


Ala Val  Gly Ser Ile Ala Ala  Xaa Leu Lys Met Lys  Gln Gly Pro 
    1370                 1375                 1380             


Met Xaa  Gln Ala Ile Asn Arg  Glu Asn Trp Cys Xaa  Ile Glu Pro 
    1385                 1390                 1395             


Cys Pro  Asp Ala Ala Ser Leu  Leu Ala Ser Lys Gln  Ser Pro Glu 
    1400                 1405                 1410             


Cys Glu  Asn Phe Leu Asp Val  Gly Leu Gly Arg Glu  Cys Xaa Ser 
    1415                 1420                 1425             


Lys Gln  Gly Val Leu Lys Arg  Glu Ser Gly Ser Asp  Ser Asp Leu 
    1430                 1435                 1440             


Phe His  Ser Pro Ser Asp Asp  Met Asp Ser Ile Ile  Phe Pro Lys 
    1445                 1450                 1455             


Pro Glu  Glu Glu His Leu Ala  Cys Asp Ile Xaa Gly  Ser Ser Ser 
    1460                 1465                 1470             


Ser Xaa  Asp Asp Xaa Ala Ser  Leu Asp Arg His Ser  Ser His Gly 
    1475                 1480                 1485             


Ser Asp  Val Ser Leu Ser Gln  Ile Leu Lys Pro Asn  Arg Ser Arg 
    1490                 1495                 1500             


Asp Arg  Gln Ser Leu Asp Gly  Phe Tyr Ser His Gly  Met Gly Ala 
    1505                 1510                 1515             


Glu Gly  Arg Glu Ser Glu Ser  Glu Pro Ala Asp Pro  Gly Asp Val 
    1520                 1525                 1530             


Glu Glu  Glu Glu Met Asp Ser  Ile Xaa Glu Val Pro  Ala Asn Cys 
    1535                 1540                 1545             


Ser Val  Leu Arg Ser Ser Met  Arg Ser Leu Ser Pro  Phe Arg Arg 
    1550                 1555                 1560             


His Ser  Trp Gly Pro Gly Lys  Asn Ala Ala Ser Asp  Ala Glu Met 
    1565                 1570                 1575             


Asn His  Arg Ser Ser Met Arg  Val Leu Gly Asp Val  Val Arg Arg 
    1580                 1585                 1590             


Pro Pro  Ile His Arg Arg Ser  Phe Ser Leu Glu Gly  Leu Xaa Gly 
    1595                 1600                 1605             


Gly Ala  Gly Val Gly Asn Lys  Pro Ser Ser Ser Leu  Glu Val Ser 
    1610                 1615                 1620             


Ser Ala  Asn Ala Glu Glu Leu  Arg His Pro Phe Ser  Gly Glu Glu 
    1625                 1630                 1635             


Arg Val  Asp Ser Leu Val Ser  Leu Ser Glu Glu Asp  Leu Glu Ser 
    1640                 1645                 1650             


Asp Gln  Arg Glu His Arg Met  Phe Asp Gln Gln Ile  Cys His Arg 
    1655                 1660                 1665             


Ser Lys  Gln Gln Gly Phe Asn  Tyr Cys Xaa Ser Ala  Ile Ser Ser 
    1670                 1675                 1680             


Pro Leu  Xaa Lys Ser Ile Ser  Leu Met Xaa Ile Ser  His Pro Gly 
    1685                 1690                 1695             


Leu Asp  Asn Ser Arg Pro Phe  His Ser Xaa Phe His  Asn Xaa Ser 
    1700                 1705                 1710             


Ala Asn  Leu Xaa Glu Ser Ile  Xaa Glu Glu Asn Tyr  Asn Phe Leu 
    1715                 1720                 1725             


Pro His  Ser Pro Ser Lys Lys  Asp Ser Glu Trp Lys  Ser Gly Xaa 
    1730                 1735                 1740             


Lys Val  Ser Arg Xaa Phe Ser  Tyr Ile Lys Asn Lys  Met Ser Ser 
    1745                 1750                 1755             


Ser Lys  Lys Ser Lys Glu Lys  Glu Lys Glu Lys Asp  Lys Ile Lys 
    1760                 1765                 1770             


Glu Lys  Glu Lys Asp Ser Lys  Asp Lys Glu Lys Asp  Lys Lys Xaa 
    1775                 1780                 1785             


Val Asn  Gly His Xaa Phe Ser  Ser Ile Pro Val Val  Gly Pro Ile 
    1790                 1795                 1800             


Ser Cys  Ser Gln Cys Met Lys  Pro Phe Xaa Asn Lys  Asp Ala Tyr 
    1805                 1810                 1815             


Xaa Cys  Ala Asn Cys Ser Ala  Phe Val His Lys Gly  Cys Arg Glu 
    1820                 1825                 1830             


Ser Leu  Ala Ser Cys Ala Lys  Val Lys Met Lys Gln  Pro Lys Gly 
    1835                 1840                 1845             


Ser Leu  Gln Ala His Asp Xaa  Ser Ser Leu Pro Xaa  Val Ile Met 
    1850                 1855                 1860             


Arg Asn  Lys Pro Ser Gln Pro  Lys Glu Arg Pro Arg  Ser Ala Val 
    1865                 1870                 1875             


Leu Leu  Val Asp Glu Xaa Ala  Xaa Xaa Pro Ile Phe  Ala Asn Arg 
    1880                 1885                 1890             


Arg Ser  Gln Gln Ser Val Ser  Leu Ser Lys Ser Val  Ser Ile Gln 
    1895                 1900                 1905             


Asn Ile  Xaa Gly Val Gly Asn  Asp Glu Asn Met Ser  Asn Xaa Trp 
    1910                 1915                 1920             


Lys Phe  Leu Ser His Ser Xaa  Asp Ser Leu Asn Lys  Ile Ser Lys 
    1925                 1930                 1935             


Val Asn  Glu Ser Xaa Glu Ser  Leu Xaa Asp Glu Gly  Val Gly Xaa 
    1940                 1945                 1950             


Asp Met  Asn Glu Gly Gln Leu  Leu Gly Asp Phe Glu  Ile Glu Ser 
    1955                 1960                 1965             


Lys Gln  Leu Glu Ala Glu Ser  Trp Ser Arg Ile Ile  Asp Ser Lys 
    1970                 1975                 1980             


Phe Leu  Lys Gln Gln Lys Lys  Asp Val Val Lys Arg  Gln Glu Val 
    1985                 1990                 1995             


Ile Tyr  Glu Leu Met Gln Xaa  Glu Phe His His Val  Arg Xaa Leu 
    2000                 2005                 2010             


Lys Ile  Met Ser Gly Val Tyr  Ser Gln Gly Met Met  Ala Asp Leu 
    2015                 2020                 2025             


Leu Phe  Glu Gln Gln Met Val  Glu Lys Leu Phe Pro  Cys Leu Asp 
    2030                 2035                 2040             


Glu Leu  Ile Ser Ile His Ser  Gln Phe Phe Gln Arg  Ile Leu Glu 
    2045                 2050                 2055             


Arg Lys  Lys Glu Ser Leu Val  Asp Lys Ser Glu Lys  Asn Phe Leu 
    2060                 2065                 2070             


Ile Lys  Arg Ile Gly Asp Val  Leu Val Asn Gln Phe  Ser Gly Glu 
    2075                 2080                 2085             


Asn Ala  Glu Arg Leu Lys Lys  Xaa Tyr Gly Lys Phe  Cys Gly Gln 
    2090                 2095                 2100             


His Asn  Gln Ser Val Asn Tyr  Phe Lys Asp Leu Tyr  Ala Lys Asp 
    2105                 2110                 2115             


Lys Arg  Phe Gln Ala Phe Val  Lys Lys Lys Met Ser  Ser Ser Val 
    2120                 2125                 2130             


Val Arg  Arg Leu Gly Ile Pro  Glu Cys Ile Leu Leu  Val Xaa Gln 
    2135                 2140                 2145             


Arg Ile  Xaa Lys Tyr Pro Val  Leu Phe Gln Arg Ile  Leu Gln Cys 
    2150                 2155                 2160             


Xaa Lys  Asp Asn Glu Val Glu  Gln Glu Asp Leu Ala  Gln Ser Leu 
    2165                 2170                 2175             


Ser Leu  Val Lys Asp Val Ile  Gly Ala Val Asp Ser  Lys Val Ala 
    2180                 2185                 2190             


Ser Tyr  Glu Lys Lys Val Arg  Leu Asn Glu Ile Tyr  Xaa Lys Xaa 
    2195                 2200                 2205             


Asp Ser  Lys Ser Ile Met Arg  Met Lys Ser Gly Gln  Met Phe Ala 
    2210                 2215                 2220             


Lys Glu  Asp Leu Lys Arg Lys  Lys Leu Val Arg Asp  Gly Ser Val 
    2225                 2230                 2235             


Phe Leu  Lys Asn Ala Ala Gly  Arg Leu Lys Glu Val  Gln Ala Val 
    2240                 2245                 2250             


Leu Leu  Xaa Asp Ile Leu Val  Phe Leu Gln Glu Lys  Asp Gln Lys 
    2255                 2260                 2265             


Tyr Ile  Phe Ala Ser Leu Asp  Gln Lys Ser Xaa Val  Ile Ser Leu 
    2270                 2275                 2280             


Lys Lys  Leu Ile Val Arg Glu  Val Ala His Glu Glu  Lys Gly Leu 
    2285                 2290                 2295             


Phe Leu  Ile Ser Met Gly Met  Xaa Asp Pro Glu Met  Val Glu Val 
    2300                 2305                 2310             


His Ala  Ser Ser Lys Glu Glu  Arg Asn Ser Trp Ile  Gln Ile Ile 
    2315                 2320                 2325             


Gln Asp  Xaa Ile Asn Xaa Leu  Asn Arg Asp Glu Asp  Glu Gly Ile 
    2330                 2335                 2340             


Pro Ser  Glu Asn Glu Glu Glu  Lys Lys Met Leu Asp  Xaa Arg Ala 
    2345                 2350                 2355             


Arg Glu  Leu Lys Glu Gln Leu  His Gln Lys Asp Gln  Lys Ile Leu 
    2360                 2365                 2370             


Leu Leu  Leu Glu Glu Lys Glu  Met Ile Phe Arg Asp  Met Ala Glu 
    2375                 2380                 2385             


Cys Ser  Xaa Pro Leu Pro Glu  Asp Cys Ser Pro Xaa  His Ser Pro 
    2390                 2395                 2400             


Arg Val  Leu Phe Arg Ser Asn  Xaa Glu Glu Ala Leu  Lys Gly Gly 
    2405                 2410                 2415             


Pro Leu  Met Lys Ser Ala Ile  Asn Glu Val Glu Ile  Leu Gln Gly 
    2420                 2425                 2430             


Leu Val  Ser Gly Asn Leu Gly  Gly Xaa Leu Gly Pro  Xaa Val Ser 
    2435                 2440                 2445             


Ser Pro  Ile Glu Gln Asp Val  Val Gly Pro Val Ser  Leu Pro Arg 
    2450                 2455                 2460             


Arg Ala  Glu Xaa Phe Gly Gly  Phe Asp Ser His Gln  Met Asn Ala 
    2465                 2470                 2475             


Ser Lys  Gly Gly Glu Lys Glu  Glu Gly Asp Asp Gly  Gln Asp Leu 
    2480                 2485                 2490             


Arg Arg  Xaa Glu Ser Asp Ser  Gly Leu Lys Lys Gly  Gly Asn Ala 
    2495                 2500                 2505             


Asn Leu  Val Phe Met Leu Lys  Arg Asn Ser Glu Gln  Val Val Gln 
    2510                 2515                 2520             


Ser Val  Val His Leu Tyr Glu  Leu Leu Ser Ala Leu  Gln Gly Val 
    2525                 2530                 2535             


Val Leu  Gln Gln Asp Ser Tyr  Ile Glu Asp Gln Lys  Leu Val Leu 
    2540                 2545                 2550             


Ser Glu  Arg Ala Leu Xaa Arg  Ser Leu Ser Arg Pro  Ser Ser Leu 
    2555                 2560                 2565             


Ile Glu  Gln Glu Lys Gln Arg  Ser Leu Glu Lys Gln  Arg Gln Asp 
    2570                 2575                 2580             


Leu Ala  Asn Leu Gln Lys Gln  Gln Ala Gln Tyr Leu  Glu Glu Lys 
    2585                 2590                 2595             


Arg Arg  Arg Glu Arg Glu Trp  Glu Ala Arg Glu Arg  Glu Leu Arg 
    2600                 2605                 2610             


Glu Arg  Glu Ala Leu Leu Ala  Gln Arg Glu Glu Glu  Val Gln Gln 
    2615                 2620                 2625             


Gly Gln  Gln Asp Leu Glu Lys  Glu Arg Glu Glu Leu  Gln Gln Lys 
    2630                 2635                 2640             


Lys Gly  Xaa Tyr Gln Tyr Asp  Leu Glu Arg Leu Arg  Ala Ala Gln 
    2645                 2650                 2655             


Lys Gln  Leu Glu Arg Glu Gln  Glu Gln Leu Arg Arg  Glu Ala Glu 
    2660                 2665                 2670             


Arg Leu  Ser Gln Arg Gln Xaa  Glu Arg Asp Leu Cys  Gln Val Ser 
    2675                 2680                 2685             


His Pro  His Xaa Lys Leu Met  Arg Ile Pro Ser Phe  Phe Pro Ser 
    2690                 2695                 2700             


Pro Glu  Glu Pro Pro Ser Pro  Ser Ala Pro Ser Ile  Ala Lys Ser 
    2705                 2710                 2715             


Gly Ser  Leu Asp Ser Glu Leu  Ser Val Ser Pro Lys  Arg Asn Ser 
    2720                 2725                 2730             


Ile Ser  Arg Xaa His Lys Asp  Lys Gly Pro Phe His  Ile Leu Ser 
    2735                 2740                 2745             


Ser Xaa  Ser Gln Xaa Asn Lys  Gly Pro Glu Gly Gln  Ser Gln Ala 
    2750                 2755                 2760             


Pro Ala  Ser Xaa Ser Ala Ser  Xaa Arg Leu Phe Gly  Leu Xaa Lys 
    2765                 2770                 2775             


Pro Lys  Glu Lys Lys Glu Lys  Lys Lys Lys Asn Lys  Xaa Ser Arg 
    2780                 2785                 2790             


Ser Gln  Pro Gly Asp Gly Pro  Ala Ser Glu Val Ser  Ala Glu Gly 
    2795                 2800                 2805             


Glu Glu  Ile Phe Cys 
    2810             


<210> 2090
<211> 2817
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1197)..(1197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1297)..(1297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1314)..(1314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1319)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1395)..(1395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1469)..(1469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1475)..(1475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1478)..(1478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1611)..(1611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1682)..(1682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1690)..(1690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1697)..(1697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1712)..(1712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1716)..(1716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1725)..(1725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1747)..(1747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1752)..(1752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1792)..(1792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1797)..(1797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1817)..(1817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1823)..(1823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1859)..(1859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1864)..(1864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1888)..(1888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1890)..(1891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1915)..(1915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1926)..(1926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1934)..(1934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1947)..(1947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1951)..(1951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1957)..(1957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2009)..(2009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2016)..(2016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2100)..(2100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2151)..(2151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2155)..(2155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2168)..(2168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2210)..(2210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2212)..(2212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2260)..(2260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2283)..(2283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2310)..(2310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2335)..(2335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2338)..(2338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2360)..(2360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2395)..(2395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2404)..(2404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2415)..(2415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2446)..(2446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2450)..(2450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2471)..(2471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2500)..(2500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2563)..(2563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2650)..(2650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2684)..(2684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2696)..(2696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2741)..(2741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2754)..(2754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2757)..(2757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2771)..(2771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2775)..(2775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2781)..(2781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2795)..(2795)
<223> Selenocysteine

<400> 2090
Met Lys Leu Asn Pro Gln Gln Ala Pro Leu Tyr Gly Asp Cys Val Val 
1               5                   10                  15      


Xaa Val Leu Leu Ala Glu Glu Asp Lys Ala Glu Asp Asp Val Val Phe 
            20                  25                  30          


Tyr Leu Val Phe Leu Gly Ser Xaa Leu Arg His Cys Xaa Ser Xaa Arg 
        35                  40                  45              


Lys Val Ser Ser Asp Xaa Leu Glu Xaa Ile Ala Pro Gly His Asp Cys 
    50                  55                  60                  


Cys Glu Xaa Val Lys Val Gln Leu Cys Ala Ser Lys Glu Gly Leu Pro 
65                  70                  75                  80  


Val Phe Val Val Ala Glu Glu Asp Phe His Phe Val Gln Asp Glu Ala 
                85                  90                  95      


Tyr Asp Ala Ala Gln Phe Leu Ala Xaa Ser Ala Gly Asn Gln Gln Ala 
            100                 105                 110         


Leu Asn Phe Xaa Arg Phe Leu Asp Gln Ser Gly Pro Pro Ser Gly Asp 
        115                 120                 125             


Val Asn Ser Leu Asp Lys Lys Leu Val Leu Ala Phe Arg His Leu Lys 
    130                 135                 140                 


Leu Pro Xaa Glu Trp Asn Val Leu Gly Xaa Asp Gln Ser Leu His Asp 
145                 150                 155                 160 


Ala Gly Pro Arg Glu Xaa Leu Met His Phe Ala Val Arg Leu Gly Leu 
                165                 170                 175     


Leu Arg Leu Xaa Trp Phe Leu Leu Gln Lys Pro Gly Gly Arg Gly Ala 
            180                 185                 190         


Leu Ser Ile His Asn Gln Glu Gly Ala Xaa Pro Val Ser Leu Ala Leu 
        195                 200                 205             


Glu Arg Gly Tyr His Lys Leu His Gln Leu Leu Xaa Glu Glu Asn Ala 
    210                 215                 220                 


Gly Glu Pro Asp Ser Trp Ser Ser Leu Ser Tyr Glu Ile Pro Tyr Gly 
225                 230                 235                 240 


Asp Cys Ser Val Arg His His Arg Glu Leu Asp Ile Tyr Xaa Leu Xaa 
                245                 250                 255     


Ser Glu Ser Asp Ser His His Glu His Pro Phe Pro Gly Asp Gly Cys 
            260                 265                 270         


Xaa Gly Pro Ile Phe Lys Leu Met Asn Ile Gln Gln Gln Leu Met Lys 
        275                 280                 285             


Xaa Asn Leu Lys Gln Met Asp Ser Leu Met Pro Leu Met Met Xaa Ala 
    290                 295                 300                 


Gln Asp Pro Ser Ser Ala Pro Glu Xaa Asp Gly Gln Phe Leu Pro Cys 
305                 310                 315                 320 


Ala Pro Glu Pro Xaa Asp Pro Gln Arg Leu Ser Ser Ser Glu Glu Xaa 
                325                 330                 335     


Glu Ser Xaa Gln Cys Cys Pro Gly Ser Pro Val Ala Gln Xaa Glu Ser 
            340                 345                 350         


Pro Cys Asp Leu Ser Ser Ile Val Glu Glu Glu Asn Xaa Asp Arg Ser 
        355                 360                 365             


Cys Arg Lys Lys Asn Lys Gly Val Glu Arg Lys Gly Glu Glu Val Glu 
    370                 375                 380                 


Pro Ala Pro Ile Val Asp Ser Gly Xaa Val Ser Asp Gln Asp Ser Cys 
385                 390                 395                 400 


Leu Gln Ser Leu Pro Asp Cys Gly Val Lys Gly Xaa Glu Gly Leu Ser 
                405                 410                 415     


Ser Cys Gly Asn Arg Asn Glu Glu Xaa Gly Xaa Lys Ser Ser Gly Met 
            420                 425                 430         


Pro Xaa Asp Gln Glu Ser Leu Ser Ser Gly Asp Ala Val Leu Gln Arg 
        435                 440                 445             


Asp Leu Val Met Glu Pro Gly Xaa Ala Gln Tyr Ser Ser Gly Gly Glu 
    450                 455                 460                 


Leu Gly Gly Ile Ser Xaa Xaa Asn Val Ser Xaa Pro Asp Xaa Ala Gly 
465                 470                 475                 480 


Glu Met Glu His Gly Leu Met Asn Pro Asp Ala Xaa Val Trp Lys Asn 
                485                 490                 495     


Val Leu Gln Gly Gly Glu Ser Xaa Lys Glu Arg Phe Glu Asn Ser Asn 
            500                 505                 510         


Ile Gly Xaa Ala Gly Ala Ser Asp Val His Val Xaa Ser Lys Pro Val 
        515                 520                 525             


Asp Lys Ile Ser Val Pro Asn Cys Ala Pro Ala Ala Ser Ser Leu Asp 
    530                 535                 540                 


Gly Asn Lys Pro Ala Glu Ser Ser Leu Ala Phe Ser Asn Glu Glu Xaa 
545                 550                 555                 560 


Ser Xaa Glu Lys Xaa Ala Glu Xaa Glu Xaa Ser Arg Ser Arg Glu Glu 
                565                 570                 575     


Ser Ala Asp Ala Pro Val Asp Gln Asn Ser Val Val Ile Pro Ala Ala 
            580                 585                 590         


Ala Lys Asp Lys Ile Ser Asp Gly Leu Glu Pro Tyr Xaa Leu Leu Ala 
        595                 600                 605             


Ala Gly Ile Gly Glu Ala Met Ser Pro Ser Asp Leu Ala Leu Leu Gly 
    610                 615                 620                 


Leu Glu Glu Asp Val Met Pro His Gln Asn Ser Glu Xaa Asn Ser Ser 
625                 630                 635                 640 


His Ala Gln Ser Gln Lys Gly Lys Ser Ser Pro Ile Cys Ser Xaa Xaa 
                645                 650                 655     


Gly Asp Asp Lys Leu Cys Ala Asp Ser Ala Cys Gln Gln Asn Xaa Val 
            660                 665                 670         


Xaa Ser Ser Gly Asp Leu Val Ala Lys Leu Cys Asp Asn Ile Val Ser 
        675                 680                 685             


Glu Ser Glu Ser Xaa Xaa Ala Arg Gln Pro Ser Ser Gln Asp Pro Pro 
    690                 695                 700                 


Asp Ala Ser His Cys Glu Asp Pro Gln Ala His Xaa Val Xaa Ser Asp 
705                 710                 715                 720 


Pro Val Arg Asp Xaa Gln Glu Arg Ala Asp Phe Cys Pro Phe Lys Val 
                725                 730                 735     


Val Asp Asn Lys Gly Gln Arg Lys Asp Val Lys Leu Asp Lys Pro Leu 
            740                 745                 750         


Xaa Asn Met Leu Glu Val Val Ser His Pro His Pro Val Val Pro Lys 
        755                 760                 765             


Met Glu Lys Glu Leu Val Pro Asp Gln Ala Val Ile Ser Asp Ser Xaa 
    770                 775                 780                 


Phe Ser Leu Ala Asn Ser Pro Gly Ser Glu Ser Val Xaa Lys Asp Asp 
785                 790                 795                 800 


Ala Leu Ser Phe Val Pro Ser Gln Lys Glu Lys Gly Xaa Ala Xaa Pro 
                805                 810                 815     


Glu Leu His Xaa Ala Xaa Asp Tyr Arg Asp Gly Pro Asp Gly Asn Ser 
            820                 825                 830         


Asn Glu Pro Asp Xaa Arg Pro Leu Glu Asp Arg Ala Val Gly Leu Ser 
        835                 840                 845             


Xaa Ser Ser Xaa Ala Ala Glu Leu Gln His Gly Met Gly Asn Xaa Ser 
    850                 855                 860                 


Leu Xaa Gly Leu Gly Gly Glu His Glu Gly Pro Ala Pro Pro Ala Ile 
865                 870                 875                 880 


Pro Glu Ala Leu Asn Ile Lys Gly Asn Xaa Asp Ser Ser Leu Gln Ser 
                885                 890                 895     


Val Gly Lys Ala Xaa Leu Ala Leu Asp Ser Val Leu Xaa Glu Glu Gly 
            900                 905                 910         


Lys Leu Leu Val Val Ser Glu Ser Ser Ala Ala Gln Glu Gln Asp Lys 
        915                 920                 925             


Asp Lys Ala Val Xaa Cys Ser Ser Ile Lys Glu Asn Ala Leu Ser Ser 
    930                 935                 940                 


Gly Xaa Leu Gln Glu Glu Gln Arg Xaa Pro Pro Pro Gly Gln Asp Xaa 
945                 950                 955                 960 


Gln Gln Phe His Glu Lys Ser Ile Ser Ala Asp Cys Ala Lys Asp Lys 
                965                 970                 975     


Ala Leu Gln Leu Ser Asn Ser Pro Gly Ala Ser Ser Ala Phe Leu Lys 
            980                 985                 990         


Ala Glu Xaa Glu His Asn Lys Glu  Val Ala Pro Gln Val  Ser Leu Leu 
        995                 1000                 1005             


Xaa Gln  Gly Gly Ala Ala Gln  Ser Leu Val Pro Pro  Gly Ala Ser 
    1010                 1015                 1020             


Leu Ala  Xaa Glu Ser Arg Gln  Glu Ala Leu Gly Ala  Glu His Asn 
    1025                 1030                 1035             


Ser Ser  Ala Leu Leu Pro Cys  Leu Leu Pro Asp Gly  Ser Asp Gly 
    1040                 1045                 1050             


Ser Asp  Ala Leu Asn Cys Ser  Gln Pro Ser Pro Leu  Asp Val Gly 
    1055                 1060                 1065             


Val Lys  Asn Xaa Gln Ser Gln  Gly Lys Xaa Ser Ala  Cys Glu Val 
    1070                 1075                 1080             


Ser Gly  Asp Val Xaa Val Asp  Val Xaa Gly Val Asn  Ala Leu Gln 
    1085                 1090                 1095             


Gly Met  Ala Glu Pro Arg Arg  Glu Asn Ile Ser His  Asn Xaa Gln 
    1100                 1105                 1110             


Asp Ile  Leu Ile Pro Asn Val  Leu Leu Ser Gln Glu  Lys Asn Ala 
    1115                 1120                 1125             


Val Leu  Gly Leu Pro Val Ala  Leu Gln Asp Lys Ala  Val Xaa Asp 
    1130                 1135                 1140             


Pro Gln  Gly Val Gly Xaa Pro  Glu Met Ile Pro Leu  Asp Trp Glu 
    1145                 1150                 1155             


Lys Gly  Lys Leu Glu Gly Ala  Asp His Ser Cys Xaa  Met Gly Asp 
    1160                 1165                 1170             


Ala Glu  Glu Ala Gln Ile Asp  Asp Glu Ala His Pro  Val Leu Leu 
    1175                 1180                 1185             


Gln Pro  Val Ala Lys Glu Leu  Pro Xaa Asp Met Glu  Leu Ser Ala 
    1190                 1195                 1200             


His Asp  Asp Gly Ala Pro Ala  Gly Val Arg Glu Val  Met Arg Ala 
    1205                 1210                 1215             


Pro Pro  Ser Gly Arg Glu Arg  Ser Xaa Pro Ser Leu  Pro Cys Met 
    1220                 1225                 1230             


Val Ser  Ala Gln Asp Ala Pro  Leu Pro Lys Gly Ala  Asp Leu Ile 
    1235                 1240                 1245             


Glu Glu  Ala Ala Ser Arg Ile  Val Asp Ala Val Ile  Glu Gln Val 
    1250                 1255                 1260             


Lys Ala  Ala Gly Ala Leu Leu  Xaa Glu Gly Glu Ala  Cys His Met 
    1265                 1270                 1275             


Ser Leu  Ser Ser Pro Glu Leu  Gly Pro Leu Xaa Lys  Gly Leu Glu 
    1280                 1285                 1290             


Ser Ala  Phe Xaa Glu Lys Val  Ser Xaa Phe Pro Pro  Gly Glu Ser 
    1295                 1300                 1305             


Leu Pro  Met Gly Ser Xaa Pro  Glu Glu Ala Xaa Gly  Ser Leu Ala 
    1310                 1315                 1320             


Gly Cys  Phe Ala Gly Arg Glu  Glu Pro Glu Lys Ile  Ile Leu Pro 
    1325                 1330                 1335             


Val Gln  Gly Pro Glu Pro Ala  Ala Glu Met Pro Asp  Val Lys Ala 
    1340                 1345                 1350             


Glu Asp  Glu Val Asp Phe Arg  Ala Ser Ser Ile Ser  Glu Glu Val 
    1355                 1360                 1365             


Ala Val  Gly Ser Ile Ala Ala  Xaa Leu Lys Met Lys  Gln Gly Pro 
    1370                 1375                 1380             


Met Xaa  Gln Ala Ile Asn Arg  Glu Asn Trp Cys Xaa  Ile Glu Pro 
    1385                 1390                 1395             


Cys Pro  Asp Ala Ala Ser Leu  Leu Ala Ser Lys Gln  Ser Pro Glu 
    1400                 1405                 1410             


Cys Glu  Asn Phe Leu Asp Val  Gly Leu Gly Arg Glu  Cys Xaa Ser 
    1415                 1420                 1425             


Lys Gln  Gly Val Leu Lys Arg  Glu Ser Gly Ser Asp  Ser Asp Leu 
    1430                 1435                 1440             


Phe His  Ser Pro Ser Asp Asp  Met Asp Ser Ile Ile  Phe Pro Lys 
    1445                 1450                 1455             


Pro Glu  Glu Glu His Leu Ala  Cys Asp Ile Xaa Gly  Ser Ser Ser 
    1460                 1465                 1470             


Ser Xaa  Asp Asp Xaa Ala Ser  Leu Asp Arg His Ser  Ser His Gly 
    1475                 1480                 1485             


Ser Asp  Val Ser Leu Ser Gln  Ile Leu Lys Pro Asn  Arg Ser Arg 
    1490                 1495                 1500             


Asp Arg  Gln Ser Leu Asp Gly  Phe Tyr Ser His Gly  Met Gly Ala 
    1505                 1510                 1515             


Glu Gly  Arg Glu Ser Glu Ser  Glu Pro Ala Asp Pro  Gly Asp Val 
    1520                 1525                 1530             


Glu Glu  Glu Glu Met Asp Ser  Ile Xaa Glu Val Pro  Ala Asn Cys 
    1535                 1540                 1545             


Ser Val  Leu Arg Ser Ser Met  Arg Ser Leu Ser Pro  Phe Arg Arg 
    1550                 1555                 1560             


His Ser  Trp Gly Pro Gly Lys  Asn Ala Ala Ser Asp  Ala Glu Met 
    1565                 1570                 1575             


Asn His  Arg Ser Met Ser Trp  Cys Pro Ser Gly Val  Gln Tyr Ser 
    1580                 1585                 1590             


Ala Gly  Leu Ser Ala Asp Phe  Asn Tyr Arg Ser Phe  Ser Leu Glu 
    1595                 1600                 1605             


Gly Leu  Xaa Gly Gly Ala Gly  Val Gly Asn Lys Pro  Ser Ser Ser 
    1610                 1615                 1620             


Leu Glu  Val Ser Ser Ala Asn  Ala Glu Glu Leu Arg  His Pro Phe 
    1625                 1630                 1635             


Ser Gly  Glu Glu Arg Val Asp  Ser Leu Val Ser Leu  Ser Glu Glu 
    1640                 1645                 1650             


Asp Leu  Glu Ser Asp Gln Arg  Glu His Arg Met Phe  Asp Gln Gln 
    1655                 1660                 1665             


Ile Cys  His Arg Ser Lys Gln  Gln Gly Phe Asn Tyr  Cys Xaa Ser 
    1670                 1675                 1680             


Ala Ile  Ser Ser Pro Leu Xaa  Lys Ser Ile Ser Leu  Met Xaa Ile 
    1685                 1690                 1695             


Ser His  Pro Gly Leu Asp Asn  Ser Arg Pro Phe His  Ser Xaa Phe 
    1700                 1705                 1710             


His Asn  Xaa Ser Ala Asn Leu  Xaa Glu Ser Ile Xaa  Glu Glu Asn 
    1715                 1720                 1725             


Tyr Asn  Phe Leu Pro His Ser  Pro Ser Lys Lys Asp  Ser Glu Trp 
    1730                 1735                 1740             


Lys Ser  Gly Xaa Lys Val Ser  Arg Xaa Phe Ser Tyr  Ile Lys Asn 
    1745                 1750                 1755             


Lys Met  Ser Ser Ser Lys Lys  Ser Lys Glu Lys Glu  Lys Glu Lys 
    1760                 1765                 1770             


Asp Lys  Ile Lys Glu Lys Glu  Lys Asp Ser Lys Asp  Lys Glu Lys 
    1775                 1780                 1785             


Asp Lys  Lys Xaa Val Asn Gly  His Xaa Phe Ser Ser  Ile Pro Val 
    1790                 1795                 1800             


Val Gly  Pro Ile Ser Cys Ser  Gln Cys Met Lys Pro  Phe Xaa Asn 
    1805                 1810                 1815             


Lys Asp  Ala Tyr Xaa Cys Ala  Asn Cys Ser Ala Phe  Val His Lys 
    1820                 1825                 1830             


Gly Cys  Arg Glu Ser Leu Ala  Ser Cys Ala Lys Val  Lys Met Lys 
    1835                 1840                 1845             


Gln Pro  Lys Gly Ser Leu Gln  Ala His Asp Xaa Ser  Ser Leu Pro 
    1850                 1855                 1860             


Xaa Val  Ile Met Arg Asn Lys  Pro Ser Gln Pro Lys  Glu Arg Pro 
    1865                 1870                 1875             


Arg Ser  Ala Val Leu Leu Val  Asp Glu Xaa Ala Xaa  Xaa Pro Ile 
    1880                 1885                 1890             


Phe Ala  Asn Arg Arg Ser Gln  Gln Ser Val Ser Leu  Ser Lys Ser 
    1895                 1900                 1905             


Val Ser  Ile Gln Asn Ile Xaa  Gly Val Gly Asn Asp  Glu Asn Met 
    1910                 1915                 1920             


Ser Asn  Xaa Trp Lys Phe Leu  Ser His Ser Xaa Asp  Ser Leu Asn 
    1925                 1930                 1935             


Lys Ile  Ser Lys Val Asn Glu  Ser Xaa Glu Ser Leu  Xaa Asp Glu 
    1940                 1945                 1950             


Gly Val  Gly Xaa Asp Met Asn  Glu Gly Gln Leu Leu  Gly Asp Phe 
    1955                 1960                 1965             


Glu Ile  Glu Ser Lys Gln Leu  Glu Ala Glu Ser Trp  Ser Arg Ile 
    1970                 1975                 1980             


Ile Asp  Ser Lys Phe Leu Lys  Gln Gln Lys Lys Asp  Val Val Lys 
    1985                 1990                 1995             


Arg Gln  Glu Val Ile Tyr Glu  Leu Met Gln Xaa Glu  Phe His His 
    2000                 2005                 2010             


Val Arg  Xaa Leu Lys Ile Met  Ser Gly Val Tyr Ser  Gln Gly Met 
    2015                 2020                 2025             


Met Ala  Asp Leu Leu Phe Glu  Gln Gln Met Val Glu  Lys Leu Phe 
    2030                 2035                 2040             


Pro Cys  Leu Asp Glu Leu Ile  Ser Ile His Ser Gln  Phe Phe Gln 
    2045                 2050                 2055             


Arg Ile  Leu Glu Arg Lys Lys  Glu Ser Leu Val Asp  Lys Ser Glu 
    2060                 2065                 2070             


Lys Asn  Phe Leu Ile Lys Arg  Ile Gly Asp Val Leu  Val Asn Gln 
    2075                 2080                 2085             


Phe Ser  Gly Glu Asn Ala Glu  Arg Leu Lys Lys Xaa  Tyr Gly Lys 
    2090                 2095                 2100             


Phe Cys  Gly Gln His Asn Gln  Ser Val Asn Tyr Phe  Lys Asp Leu 
    2105                 2110                 2115             


Tyr Ala  Lys Asp Lys Arg Phe  Gln Ala Phe Val Lys  Lys Lys Met 
    2120                 2125                 2130             


Ser Ser  Ser Val Val Arg Arg  Leu Gly Ile Pro Glu  Cys Ile Leu 
    2135                 2140                 2145             


Leu Val  Xaa Gln Arg Ile Xaa  Lys Tyr Pro Val Leu  Phe Gln Arg 
    2150                 2155                 2160             


Ile Leu  Gln Cys Xaa Lys Asp  Asn Glu Val Glu Gln  Glu Asp Leu 
    2165                 2170                 2175             


Ala Gln  Ser Leu Ser Leu Val  Lys Asp Val Ile Gly  Ala Val Asp 
    2180                 2185                 2190             


Ser Lys  Val Ala Ser Tyr Glu  Lys Lys Val Arg Leu  Asn Glu Ile 
    2195                 2200                 2205             


Tyr Xaa  Lys Xaa Asp Ser Lys  Ser Ile Met Arg Met  Lys Ser Gly 
    2210                 2215                 2220             


Gln Met  Phe Ala Lys Glu Asp  Leu Lys Arg Lys Lys  Leu Val Arg 
    2225                 2230                 2235             


Asp Gly  Ser Val Phe Leu Lys  Asn Ala Ala Gly Arg  Leu Lys Glu 
    2240                 2245                 2250             


Val Gln  Ala Val Leu Leu Xaa  Asp Ile Leu Val Phe  Leu Gln Glu 
    2255                 2260                 2265             


Lys Asp  Gln Lys Tyr Ile Phe  Ala Ser Leu Asp Gln  Lys Ser Xaa 
    2270                 2275                 2280             


Val Ile  Ser Leu Lys Lys Leu  Ile Val Arg Glu Val  Ala His Glu 
    2285                 2290                 2295             


Glu Lys  Gly Leu Phe Leu Ile  Ser Met Gly Met Xaa  Asp Pro Glu 
    2300                 2305                 2310             


Met Val  Glu Val His Ala Ser  Ser Lys Glu Glu Arg  Asn Ser Trp 
    2315                 2320                 2325             


Ile Gln  Ile Ile Gln Asp Xaa  Ile Asn Xaa Leu Asn  Arg Asp Glu 
    2330                 2335                 2340             


Asp Glu  Gly Ile Pro Ser Glu  Asn Glu Glu Glu Lys  Lys Met Leu 
    2345                 2350                 2355             


Asp Xaa  Arg Ala Arg Glu Leu  Lys Glu Gln Leu His  Gln Lys Asp 
    2360                 2365                 2370             


Gln Lys  Ile Leu Leu Leu Leu  Glu Glu Lys Glu Met  Ile Phe Arg 
    2375                 2380                 2385             


Asp Met  Ala Glu Cys Ser Xaa  Pro Leu Pro Glu Asp  Cys Ser Pro 
    2390                 2395                 2400             


Xaa His  Ser Pro Arg Val Leu  Phe Arg Ser Asn Xaa  Glu Glu Ala 
    2405                 2410                 2415             


Leu Lys  Gly Gly Pro Leu Met  Lys Ser Ala Ile Asn  Glu Val Glu 
    2420                 2425                 2430             


Ile Leu  Gln Gly Leu Val Ser  Gly Asn Leu Gly Gly  Xaa Leu Gly 
    2435                 2440                 2445             


Pro Xaa  Val Ser Ser Pro Ile  Glu Gln Asp Val Val  Gly Pro Val 
    2450                 2455                 2460             


Ser Leu  Pro Arg Arg Ala Glu  Xaa Phe Gly Gly Phe  Asp Ser His 
    2465                 2470                 2475             


Gln Met  Asn Ala Ser Lys Gly  Gly Glu Lys Glu Glu  Gly Asp Asp 
    2480                 2485                 2490             


Gly Gln  Asp Leu Arg Arg Xaa  Glu Ser Asp Ser Gly  Leu Lys Lys 
    2495                 2500                 2505             


Gly Gly  Asn Ala Asn Leu Val  Phe Met Leu Lys Arg  Asn Ser Glu 
    2510                 2515                 2520             


Gln Val  Val Gln Ser Val Val  His Leu Tyr Glu Leu  Leu Ser Ala 
    2525                 2530                 2535             


Leu Gln  Gly Val Val Leu Gln  Gln Asp Ser Tyr Ile  Glu Asp Gln 
    2540                 2545                 2550             


Lys Leu  Val Leu Ser Glu Arg  Ala Leu Xaa Arg Ser  Leu Ser Arg 
    2555                 2560                 2565             


Pro Ser  Ser Leu Ile Glu Gln  Glu Lys Gln Arg Ser  Leu Glu Lys 
    2570                 2575                 2580             


Gln Arg  Gln Asp Leu Ala Asn  Leu Gln Lys Gln Gln  Ala Gln Tyr 
    2585                 2590                 2595             


Leu Glu  Glu Lys Arg Arg Arg  Glu Arg Glu Trp Glu  Ala Arg Glu 
    2600                 2605                 2610             


Arg Glu  Leu Arg Glu Arg Glu  Ala Leu Leu Ala Gln  Arg Glu Glu 
    2615                 2620                 2625             


Glu Val  Gln Gln Gly Gln Gln  Asp Leu Glu Lys Glu  Arg Glu Glu 
    2630                 2635                 2640             


Leu Gln  Gln Lys Lys Gly Xaa  Tyr Gln Tyr Asp Leu  Glu Arg Leu 
    2645                 2650                 2655             


Arg Ala  Ala Gln Lys Gln Leu  Glu Arg Glu Gln Glu  Gln Leu Arg 
    2660                 2665                 2670             


Arg Glu  Ala Glu Arg Leu Ser  Gln Arg Gln Xaa Glu  Arg Asp Leu 
    2675                 2680                 2685             


Cys Gln  Val Ser His Pro His  Xaa Lys Leu Met Arg  Ile Pro Ser 
    2690                 2695                 2700             


Phe Phe  Pro Ser Pro Glu Glu  Pro Pro Ser Pro Ser  Ala Pro Ser 
    2705                 2710                 2715             


Ile Ala  Lys Ser Gly Ser Leu  Asp Ser Glu Leu Ser  Val Ser Pro 
    2720                 2725                 2730             


Lys Arg  Asn Ser Ile Ser Arg  Xaa His Lys Asp Lys  Gly Pro Phe 
    2735                 2740                 2745             


His Ile  Leu Ser Ser Xaa Ser  Gln Xaa Asn Lys Gly  Pro Glu Gly 
    2750                 2755                 2760             


Gln Ser  Gln Ala Pro Ala Ser  Xaa Ser Ala Ser Xaa  Arg Leu Phe 
    2765                 2770                 2775             


Gly Leu  Xaa Lys Pro Lys Glu  Lys Lys Glu Lys Lys  Lys Lys Asn 
    2780                 2785                 2790             


Lys Xaa  Ser Arg Ser Gln Pro  Gly Asp Gly Pro Ala  Ser Glu Val 
    2795                 2800                 2805             


Ser Ala  Glu Gly Glu Glu Ile  Phe Cys 
    2810                 2815         


<210> 2091
<211> 179
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<400> 2091
Met Lys Leu Asn Pro Gln Gln Ala Pro Leu Tyr Gly Asp Cys Val Val 
1               5                   10                  15      


Xaa Val Leu Leu Ala Glu Glu Asp Lys Ala Glu Asp Asp Val Val Phe 
            20                  25                  30          


Tyr Leu Val Phe Leu Gly Ser Xaa Leu Arg His Cys Xaa Ser Xaa Arg 
        35                  40                  45              


Lys Val Ser Ser Asp Xaa Leu Glu Xaa Ile Ala Pro Gly His Asp Cys 
    50                  55                  60                  


Cys Glu Xaa Val Lys Val Gln Leu Cys Ala Ser Lys Glu Gly Leu Pro 
65                  70                  75                  80  


Val Phe Val Val Ala Glu Glu Asp Phe His Phe Val Gln Asp Glu Ala 
                85                  90                  95      


Tyr Asp Ala Ala Gln Phe Leu Ala Xaa Ser Ala Gly Asn Gln Gln Ala 
            100                 105                 110         


Leu Asn Phe Xaa Arg Phe Leu Asp Gln Ser Gly Pro Pro Ser Gly Asp 
        115                 120                 125             


Val Asn Ser Leu Asp Lys Lys Leu Val Leu Ala Phe Arg His Leu Lys 
    130                 135                 140                 


Leu Pro Xaa Glu Trp Asn Val Leu Gly Xaa Asp Gln Ser Leu His Gly 
145                 150                 155                 160 


Glu Asn Leu Tyr Asp Leu Gln Xaa His Phe Lys Phe Val Ile Phe Leu 
                165                 170                 175     


Leu Phe Phe 
            


<210> 2092
<211> 1429
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1007)..(1007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1058)..(1058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1083)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1262)..(1262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1296)..(1296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1308)..(1308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1353)..(1353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1366)..(1366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1369)..(1369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1383)..(1383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1387)..(1387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1393)..(1393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1407)
<223> Selenocysteine

<400> 2092
Met Leu Tyr Ile Asn Arg Glu Asn Trp Cys Xaa Ile Glu Pro Cys Pro 
1               5                   10                  15      


Asp Ala Ala Ser Leu Leu Ala Ser Lys Gln Ser Pro Glu Cys Glu Asn 
            20                  25                  30          


Phe Leu Asp Val Gly Leu Gly Arg Glu Cys Xaa Ser Lys Gln Gly Val 
        35                  40                  45              


Leu Lys Arg Glu Ser Gly Ser Asp Ser Asp Leu Phe His Ser Pro Ser 
    50                  55                  60                  


Asp Asp Met Asp Ser Ile Ile Phe Pro Lys Pro Glu Glu Glu His Leu 
65                  70                  75                  80  


Ala Cys Asp Ile Xaa Gly Ser Ser Ser Ser Xaa Asp Asp Xaa Ala Ser 
                85                  90                  95      


Leu Asp Arg His Ser Ser His Gly Ser Asp Val Ser Leu Ser Gln Ile 
            100                 105                 110         


Leu Lys Pro Asn Arg Ser Arg Asp Arg Gln Ser Leu Asp Gly Phe Tyr 
        115                 120                 125             


Ser His Gly Met Gly Ala Glu Gly Arg Glu Ser Glu Ser Glu Pro Ala 
    130                 135                 140                 


Asp Pro Gly Asp Val Glu Glu Glu Glu Met Asp Ser Ile Xaa Glu Val 
145                 150                 155                 160 


Pro Ala Asn Cys Ser Val Leu Arg Ser Ser Met Arg Ser Leu Ser Pro 
                165                 170                 175     


Phe Arg Arg His Ser Trp Gly Pro Gly Lys Asn Ala Ala Ser Asp Ala 
            180                 185                 190         


Glu Met Asn His Arg Ser Ser Met Arg Val Leu Gly Asp Val Val Arg 
        195                 200                 205             


Arg Pro Pro Ile His Arg Arg Ser Phe Ser Leu Glu Gly Leu Xaa Gly 
    210                 215                 220                 


Gly Ala Gly Val Gly Asn Lys Pro Ser Ser Ser Leu Glu Val Ser Ser 
225                 230                 235                 240 


Ala Asn Ala Glu Glu Leu Arg His Pro Phe Ser Gly Glu Glu Arg Val 
                245                 250                 255     


Asp Ser Leu Val Ser Leu Ser Glu Glu Asp Leu Glu Ser Asp Gln Arg 
            260                 265                 270         


Glu His Arg Met Phe Asp Gln Gln Ile Cys His Arg Ser Lys Gln Gln 
        275                 280                 285             


Gly Phe Asn Tyr Cys Xaa Ser Ala Ile Ser Ser Pro Leu Xaa Lys Ser 
    290                 295                 300                 


Ile Ser Leu Met Xaa Ile Ser His Pro Gly Leu Asp Asn Ser Arg Pro 
305                 310                 315                 320 


Phe His Ser Xaa Phe His Asn Xaa Ser Ala Asn Leu Xaa Glu Ser Ile 
                325                 330                 335     


Xaa Glu Glu Asn Tyr Asn Phe Leu Pro His Ser Pro Ser Lys Lys Asp 
            340                 345                 350         


Ser Glu Trp Lys Ser Gly Xaa Lys Val Ser Arg Xaa Phe Ser Tyr Ile 
        355                 360                 365             


Lys Asn Lys Met Ser Ser Ser Lys Lys Ser Lys Glu Lys Glu Lys Glu 
    370                 375                 380                 


Lys Asp Lys Ile Lys Glu Lys Glu Lys Asp Ser Lys Asp Lys Glu Lys 
385                 390                 395                 400 


Asp Lys Lys Xaa Val Asn Gly His Xaa Phe Ser Ser Ile Pro Val Val 
                405                 410                 415     


Gly Pro Ile Ser Cys Ser Gln Cys Met Lys Pro Phe Xaa Asn Lys Asp 
            420                 425                 430         


Ala Tyr Xaa Cys Ala Asn Cys Ser Ala Phe Val His Lys Gly Cys Arg 
        435                 440                 445             


Glu Ser Leu Ala Ser Cys Ala Lys Val Lys Met Lys Gln Pro Lys Gly 
    450                 455                 460                 


Ser Leu Gln Ala His Asp Xaa Ser Ser Leu Pro Xaa Val Ile Met Arg 
465                 470                 475                 480 


Asn Lys Pro Ser Gln Pro Lys Glu Arg Pro Arg Ser Ala Val Leu Leu 
                485                 490                 495     


Val Asp Glu Xaa Ala Xaa Xaa Pro Ile Phe Ala Asn Arg Arg Ser Gln 
            500                 505                 510         


Gln Ser Val Ser Leu Ser Lys Ser Val Ser Ile Gln Asn Ile Xaa Gly 
        515                 520                 525             


Val Gly Asn Asp Glu Asn Met Ser Asn Xaa Trp Lys Phe Leu Ser His 
    530                 535                 540                 


Ser Xaa Asp Ser Leu Asn Lys Ile Ser Lys Val Asn Glu Ser Xaa Glu 
545                 550                 555                 560 


Ser Leu Xaa Asp Glu Gly Val Gly Xaa Asp Met Asn Glu Gly Gln Leu 
                565                 570                 575     


Leu Gly Asp Phe Glu Ile Glu Ser Lys Gln Leu Glu Ala Glu Ser Trp 
            580                 585                 590         


Ser Arg Ile Ile Asp Ser Lys Phe Leu Lys Gln Gln Lys Lys Asp Val 
        595                 600                 605             


Val Lys Arg Gln Glu Val Ile Tyr Glu Leu Met Gln Xaa Glu Phe His 
    610                 615                 620                 


His Val Arg Xaa Leu Lys Ile Met Ser Gly Val Tyr Ser Gln Gly Met 
625                 630                 635                 640 


Met Ala Asp Leu Leu Phe Glu Gln Gln Met Val Glu Lys Leu Phe Pro 
                645                 650                 655     


Cys Leu Asp Glu Leu Ile Ser Ile His Ser Gln Phe Phe Gln Arg Ile 
            660                 665                 670         


Leu Glu Arg Lys Lys Glu Ser Leu Val Asp Lys Ser Glu Lys Asn Phe 
        675                 680                 685             


Leu Ile Lys Arg Ile Gly Asp Val Leu Val Asn Gln Phe Ser Gly Glu 
    690                 695                 700                 


Asn Ala Glu Arg Leu Lys Lys Xaa Tyr Gly Lys Phe Cys Gly Gln His 
705                 710                 715                 720 


Asn Gln Ser Val Asn Tyr Phe Lys Asp Leu Tyr Ala Lys Asp Lys Arg 
                725                 730                 735     


Phe Gln Ala Phe Val Lys Lys Lys Met Ser Ser Ser Val Val Arg Arg 
            740                 745                 750         


Leu Gly Ile Pro Glu Cys Ile Leu Leu Val Xaa Gln Arg Ile Xaa Lys 
        755                 760                 765             


Tyr Pro Val Leu Phe Gln Arg Ile Leu Gln Cys Xaa Lys Asp Asn Glu 
    770                 775                 780                 


Val Glu Gln Glu Asp Leu Ala Gln Ser Leu Ser Leu Val Lys Asp Val 
785                 790                 795                 800 


Ile Gly Ala Val Asp Ser Lys Val Ala Ser Tyr Glu Lys Lys Val Arg 
                805                 810                 815     


Leu Asn Glu Ile Tyr Xaa Lys Xaa Asp Ser Lys Ser Ile Met Arg Met 
            820                 825                 830         


Lys Ser Gly Gln Met Phe Ala Lys Glu Asp Leu Lys Arg Lys Lys Leu 
        835                 840                 845             


Val Arg Asp Gly Ser Val Phe Leu Lys Asn Ala Ala Gly Arg Leu Lys 
    850                 855                 860                 


Glu Val Gln Ala Val Leu Leu Xaa Asp Ile Leu Val Phe Leu Gln Glu 
865                 870                 875                 880 


Lys Asp Gln Lys Tyr Ile Phe Ala Ser Leu Asp Gln Lys Ser Xaa Val 
                885                 890                 895     


Ile Ser Leu Lys Lys Leu Ile Val Arg Glu Val Ala His Glu Glu Lys 
            900                 905                 910         


Gly Leu Phe Leu Ile Ser Met Gly Met Xaa Asp Pro Glu Met Val Glu 
        915                 920                 925             


Val His Ala Ser Ser Lys Glu Glu Arg Asn Ser Trp Ile Gln Ile Ile 
    930                 935                 940                 


Gln Asp Xaa Ile Asn Xaa Leu Asn Arg Asp Glu Asp Glu Gly Ile Pro 
945                 950                 955                 960 


Ser Glu Asn Glu Glu Glu Lys Lys Met Leu Asp Xaa Arg Ala Arg Glu 
                965                 970                 975     


Leu Lys Glu Gln Leu His Gln Lys Asp Gln Lys Ile Leu Leu Leu Leu 
            980                 985                 990         


Glu Glu Lys Glu Met Ile Phe Arg  Asp Met Ala Glu Cys  Ser Xaa Pro 
        995                 1000                 1005             


Leu Pro  Glu Asp Cys Ser Pro  Xaa His Ser Pro Arg  Val Leu Phe 
    1010                 1015                 1020             


Arg Ser  Asn Xaa Glu Glu Ala  Leu Lys Gly Gly Pro  Leu Met Lys 
    1025                 1030                 1035             


Ser Ala  Ile Asn Glu Val Glu  Ile Leu Gln Gly Leu  Val Ser Gly 
    1040                 1045                 1050             


Asn Leu  Gly Gly Xaa Leu Gly  Pro Xaa Val Ser Ser  Pro Ile Glu 
    1055                 1060                 1065             


Gln Asp  Val Val Gly Pro Val  Ser Leu Pro Arg Arg  Ala Glu Xaa 
    1070                 1075                 1080             


Phe Gly  Gly Phe Asp Ser His  Gln Met Asn Ala Ser  Lys Gly Gly 
    1085                 1090                 1095             


Glu Lys  Glu Glu Gly Asp Asp  Gly Gln Asp Leu Arg  Arg Xaa Glu 
    1100                 1105                 1110             


Ser Asp  Ser Gly Leu Lys Lys  Gly Gly Asn Ala Asn  Leu Val Phe 
    1115                 1120                 1125             


Met Leu  Lys Arg Asn Ser Glu  Gln Val Val Gln Ser  Val Val His 
    1130                 1135                 1140             


Leu Tyr  Glu Leu Leu Ser Ala  Leu Gln Gly Val Val  Leu Gln Gln 
    1145                 1150                 1155             


Asp Ser  Tyr Ile Glu Asp Gln  Lys Leu Val Leu Ser  Glu Arg Ala 
    1160                 1165                 1170             


Leu Xaa  Arg Ser Leu Ser Arg  Pro Ser Ser Leu Ile  Glu Gln Glu 
    1175                 1180                 1185             


Lys Gln  Arg Ser Leu Glu Lys  Gln Arg Gln Asp Leu  Ala Asn Leu 
    1190                 1195                 1200             


Gln Lys  Gln Gln Ala Gln Tyr  Leu Glu Glu Lys Arg  Arg Arg Glu 
    1205                 1210                 1215             


Arg Glu  Trp Glu Ala Arg Glu  Arg Glu Leu Arg Glu  Arg Glu Ala 
    1220                 1225                 1230             


Leu Leu  Ala Gln Arg Glu Glu  Glu Val Gln Gln Gly  Gln Gln Asp 
    1235                 1240                 1245             


Leu Glu  Lys Glu Arg Glu Glu  Leu Gln Gln Lys Lys  Gly Xaa Tyr 
    1250                 1255                 1260             


Gln Tyr  Asp Leu Glu Arg Leu  Arg Ala Ala Gln Lys  Gln Leu Glu 
    1265                 1270                 1275             


Arg Glu  Gln Glu Gln Leu Arg  Arg Glu Ala Glu Arg  Leu Ser Gln 
    1280                 1285                 1290             


Arg Gln  Xaa Glu Arg Asp Leu  Cys Gln Val Ser His  Pro His Xaa 
    1295                 1300                 1305             


Lys Leu  Met Arg Ile Pro Ser  Phe Phe Pro Ser Pro  Glu Glu Pro 
    1310                 1315                 1320             


Pro Ser  Pro Ser Ala Pro Ser  Ile Ala Lys Ser Gly  Ser Leu Asp 
    1325                 1330                 1335             


Ser Glu  Leu Ser Val Ser Pro  Lys Arg Asn Ser Ile  Ser Arg Xaa 
    1340                 1345                 1350             


His Lys  Asp Lys Gly Pro Phe  His Ile Leu Ser Ser  Xaa Ser Gln 
    1355                 1360                 1365             


Xaa Asn  Lys Gly Pro Glu Gly  Gln Ser Gln Ala Pro  Ala Ser Xaa 
    1370                 1375                 1380             


Ser Ala  Ser Xaa Arg Leu Phe  Gly Leu Xaa Lys Pro  Lys Glu Lys 
    1385                 1390                 1395             


Lys Glu  Lys Lys Lys Lys Asn  Lys Xaa Ser Arg Ser  Gln Pro Gly 
    1400                 1405                 1410             


Asp Gly  Pro Ala Ser Glu Val  Ser Ala Glu Gly Glu  Glu Ile Phe 
    1415                 1420                 1425             


Cys 
    


<210> 2093
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 2093
Met Asn Ile Gln Gln Gln Leu Met Lys Xaa Asn Leu Lys Gln Met Asp 
1               5                   10                  15      


Ser Leu Met Pro Leu Met Met Xaa Ala Gln Asp Pro Ser Ser Ala Pro 
            20                  25                  30          


Glu Xaa Asp Gly Gln Phe Leu Pro Cys Ala Pro Glu Pro Xaa Asp Pro 
        35                  40                  45              


Gln Arg Leu Ser Ser Ser Glu Glu Xaa Glu Ser Xaa Gln Cys Cys Pro 
    50                  55                  60                  


Gly Ser Pro Val Ala Gln Xaa Glu Ser Pro Cys Asp Leu Ser Ser Ile 
65                  70                  75                  80  


Val Glu Glu Glu Asn Xaa Asp Arg Ser Cys Arg Lys Lys 
                85                  90              


<210> 2094
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 2094
Met Pro Asp Val Lys Ala Glu Asp Glu Val Asp Phe Arg Ala Ser Ser 
1               5                   10                  15      


Ile Ser Glu Glu Val Ala Val Gly Ser Ile Ala Ala Xaa Leu Lys Met 
            20                  25                  30          


Lys Gln Gly Pro Met Xaa Gln Ala Ile Asn Arg Glu Asn Trp Cys Xaa 
        35                  40                  45              


Ile Glu Pro Cys Pro Asp Ala Ala Ser Leu Leu Ala Ser Lys Gln Ser 
    50                  55                  60                  


Pro Glu Cys Glu Asn Phe Leu Asp Val Gly Leu Gly Arg Glu Cys Xaa 
65                  70                  75                  80  


Ser Lys Gln Gly Val Leu Lys Arg Glu Ser Gly Ser Asp Ser Asp Leu 
                85                  90                  95      


Phe His Ser 
            


<210> 2095
<211> 166
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<400> 2095
Met Ser Ile Lys Trp Ala Arg Phe His Glu Val Pro His Ile Xaa Val 
1               5                   10                  15      


Arg Phe Ile Gly Pro Lys His Gly Glu Glu Lys Glu Lys Glu Lys Asp 
            20                  25                  30          


Lys Ile Lys Glu Lys Glu Lys Asp Ser Lys Asp Lys Glu Lys Asp Lys 
        35                  40                  45              


Lys Xaa Val Asn Gly His Xaa Phe Ser Ser Ile Pro Val Val Gly Pro 
    50                  55                  60                  


Ile Ser Cys Ser Gln Cys Met Lys Pro Phe Xaa Asn Lys Asp Ala Tyr 
65                  70                  75                  80  


Xaa Cys Ala Asn Cys Ser Ala Phe Val His Lys Gly Cys Arg Glu Ser 
                85                  90                  95      


Leu Ala Ser Cys Ala Lys Val Lys Met Lys Gln Pro Lys Gly Ser Leu 
            100                 105                 110         


Gln Ala His Asp Xaa Ser Ser Leu Pro Xaa Val Ile Met Arg Asn Lys 
        115                 120                 125             


Pro Ser Gln Pro Lys Glu Arg Pro Arg Ser Ala Val Leu Leu Val Asp 
    130                 135                 140                 


Glu Xaa Ala Xaa Xaa Pro Ile Phe Ala Asn Arg Arg Ser Gln Gln Ser 
145                 150                 155                 160 


Val Ser Leu Ser Lys Ser 
                165     


<210> 2096
<211> 66
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 2096
Met Ser Ser Ser Lys Lys Ser Lys Glu Lys Glu Lys Glu Lys Asp Lys 
1               5                   10                  15      


Ile Lys Glu Lys Glu Lys Asp Ser Lys Asp Lys Glu Lys Asp Lys Lys 
            20                  25                  30          


Xaa Val Asn Gly His Xaa Phe Ser Ser Ile Pro Val Val Gly Pro Ile 
        35                  40                  45              


Ser Cys Ser Gln Cys Met Lys Pro Phe Xaa Asn Lys Asp Ala Tyr Xaa 
    50                  55                  60                  


Cys Ala 
65      


<210> 2097
<211> 967
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<400> 2097
Met Tyr Glu Arg His Lys Arg Arg Tyr Ser Leu Cys Asp Ile Ser Lys 
1               5                   10                  15      


Val Asp Arg Xaa Val Asp Val Val Leu Leu Lys Ile Asn Arg Glu Asn 
            20                  25                  30          


Trp Cys Xaa Ile Glu Pro Cys Pro Asp Ala Ala Ser Leu Leu Ala Ser 
        35                  40                  45              


Lys Gln Ser Pro Glu Cys Glu Asn Phe Leu Asp Val Gly Leu Gly Arg 
    50                  55                  60                  


Glu Cys Xaa Ser Lys Gln Gly Val Leu Lys Arg Glu Ser Gly Ser Asp 
65                  70                  75                  80  


Ser Asp Leu Phe His Ser Pro Ser Asp Asp Met Asp Ser Ile Ile Phe 
                85                  90                  95      


Pro Lys Pro Glu Glu Glu His Leu Ala Cys Asp Ile Xaa Gly Ser Ser 
            100                 105                 110         


Ser Ser Xaa Asp Asp Xaa Ala Ser Leu Asp Arg His Ser Ser His Gly 
        115                 120                 125             


Ser Asp Val Ser Leu Ser Gln Ile Leu Lys Pro Asn Arg Ser Arg Asp 
    130                 135                 140                 


Arg Gln Ser Leu Asp Gly Phe Tyr Ser His Gly Met Gly Ala Glu Gly 
145                 150                 155                 160 


Arg Glu Ser Glu Ser Glu Pro Ala Asp Pro Gly Asp Val Glu Glu Glu 
                165                 170                 175     


Glu Met Asp Ser Ile Xaa Glu Val Pro Ala Asn Cys Ser Val Leu Arg 
            180                 185                 190         


Ser Ser Met Arg Ser Leu Ser Pro Phe Arg Arg His Ser Trp Gly Pro 
        195                 200                 205             


Gly Lys Asn Ala Ala Ser Asp Ala Glu Met Asn His Arg Ser Phe Ser 
    210                 215                 220                 


Leu Glu Gly Leu Xaa Gly Gly Ala Gly Val Gly Asn Lys Pro Ser Ser 
225                 230                 235                 240 


Ser Leu Glu Val Ser Ser Ala Asn Ala Glu Glu Leu Arg His Pro Phe 
                245                 250                 255     


Ser Gly Glu Glu Arg Val Asp Ser Leu Val Ser Leu Ser Glu Glu Asp 
            260                 265                 270         


Leu Glu Ser Asp Gln Arg Glu His Arg Met Phe Asp Gln Gln Ile Cys 
        275                 280                 285             


His Arg Ser Lys Gln Gln Gly Phe Asn Tyr Cys Xaa Ser Ala Ile Ser 
    290                 295                 300                 


Ser Pro Leu Xaa Lys Ser Ile Ser Leu Met Xaa Ile Ser His Pro Gly 
305                 310                 315                 320 


Leu Asp Asn Ser Arg Pro Phe His Ser Xaa Phe His Asn Xaa Ser Ala 
                325                 330                 335     


Asn Leu Xaa Glu Ser Ile Xaa Glu Glu Asn Tyr Asn Phe Leu Pro His 
            340                 345                 350         


Ser Pro Ser Lys Lys Asp Ser Glu Trp Lys Ser Gly Xaa Lys Val Ser 
        355                 360                 365             


Arg Xaa Phe Ser Tyr Ile Lys Asn Lys Met Ser Ser Ser Lys Lys Ser 
    370                 375                 380                 


Lys Glu Lys Glu Lys Glu Lys Asp Lys Ile Lys Glu Lys Glu Lys Asp 
385                 390                 395                 400 


Ser Lys Asp Lys Glu Lys Asp Lys Lys Xaa Val Asn Gly His Xaa Phe 
                405                 410                 415     


Ser Ser Ile Pro Val Val Gly Pro Ile Ser Cys Ser Gln Cys Met Lys 
            420                 425                 430         


Pro Phe Xaa Asn Lys Asp Ala Tyr Xaa Cys Ala Asn Cys Ser Ala Phe 
        435                 440                 445             


Val His Lys Gly Cys Arg Glu Ser Leu Ala Ser Cys Ala Lys Val Lys 
    450                 455                 460                 


Met Lys Pro Lys Gly Ser Leu Gln Ala His Asp Xaa Ser Ser Leu Pro 
465                 470                 475                 480 


Xaa Val Ile Met Arg Asn Lys Pro Ser Gln Pro Lys Glu Arg Pro Arg 
                485                 490                 495     


Ser Ala Val Leu Leu Val Asp Glu Xaa Ala Xaa Xaa Pro Ile Phe Ala 
            500                 505                 510         


Asn Arg Arg Ser Gln Gln Ser Val Ser Leu Ser Lys Ser Val Ser Ile 
        515                 520                 525             


Gln Asn Ile Xaa Gly Val Gly Asn Asp Glu Asn Met Ser Asn Xaa Trp 
    530                 535                 540                 


Lys Phe Leu Ser His Ser Xaa Asp Ser Leu Asn Lys Ile Ser Lys Val 
545                 550                 555                 560 


Asn Glu Ser Xaa Glu Ser Leu Xaa Asp Glu Gly Val Gly Xaa Asp Met 
                565                 570                 575     


Asn Glu Gly Gln Leu Leu Gly Asp Phe Glu Ile Glu Ser Lys Gln Leu 
            580                 585                 590         


Glu Ala Glu Ser Trp Ser Arg Ile Ile Asp Ser Lys Phe Leu Lys Gln 
        595                 600                 605             


Gln Lys Lys Asp Val Val Lys Arg Gln Glu Val Ile Tyr Glu Leu Met 
    610                 615                 620                 


Gln Xaa Glu Phe His His Val Arg Xaa Leu Lys Ile Met Ser Gly Val 
625                 630                 635                 640 


Tyr Ser Gln Gly Met Met Ala Asp Leu Leu Phe Glu Gln Gln Met Val 
                645                 650                 655     


Glu Lys Leu Phe Pro Cys Leu Asp Glu Leu Ile Ser Ile His Ser Gln 
            660                 665                 670         


Phe Phe Gln Arg Ile Leu Glu Arg Lys Lys Glu Ser Leu Val Asp Lys 
        675                 680                 685             


Ser Glu Lys Asn Phe Leu Ile Lys Arg Ile Gly Asp Val Leu Val Asn 
    690                 695                 700                 


Gln Phe Ser Gly Glu Asn Ala Glu Arg Leu Lys Lys Xaa Tyr Gly Lys 
705                 710                 715                 720 


Phe Cys Gly Gln His Asn Gln Ser Val Asn Tyr Phe Lys Asp Leu Tyr 
                725                 730                 735     


Ala Lys Asp Lys Arg Phe Gln Ala Phe Val Lys Lys Lys Met Ser Ser 
            740                 745                 750         


Ser Val Val Arg Arg Leu Gly Ile Pro Glu Cys Ile Leu Leu Val Xaa 
        755                 760                 765             


Gln Arg Ile Xaa Lys Tyr Pro Val Leu Phe Gln Arg Ile Leu Gln Cys 
    770                 775                 780                 


Xaa Lys Asp Asn Glu Val Glu Gln Glu Asp Leu Ala Gln Ser Leu Ser 
785                 790                 795                 800 


Leu Val Lys Asp Val Ile Gly Ala Val Asp Ser Lys Val Ala Ser Tyr 
                805                 810                 815     


Glu Lys Lys Val Arg Leu Asn Glu Ile Tyr Xaa Lys Xaa Asp Ser Lys 
            820                 825                 830         


Ser Ile Met Arg Met Lys Ser Gly Gln Met Phe Ala Lys Glu Asp Leu 
        835                 840                 845             


Lys Arg Lys Lys Leu Val Arg Asp Gly Ser Val Phe Leu Lys Asn Ala 
    850                 855                 860                 


Ala Gly Arg Leu Lys Glu Val Gln Ala Val Leu Leu Xaa Asp Ile Leu 
865                 870                 875                 880 


Val Phe Leu Gln Glu Lys Asp Gln Lys Tyr Ile Phe Ala Ser Leu Asp 
                885                 890                 895     


Gln Lys Ser Xaa Val Ile Ser Leu Lys Lys Leu Ile Val Arg Glu Val 
            900                 905                 910         


Ala His Glu Glu Lys Gly Leu Phe Leu Ile Ser Met Gly Met Xaa Asp 
        915                 920                 925             


Pro Glu Met Val Glu Val His Ala Ser Ser Lys Glu Glu Arg Asn Ser 
    930                 935                 940                 


Trp Ile Gln Ile Ile Gln Asp Xaa Ile Asn Xaa Leu Asn Arg Asp Glu 
945                 950                 955                 960 


Asp Glu Gly Ile Pro Ser Glu 
                965         


<210> 2098
<211> 1434
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1117)..(1117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1267)..(1267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1313)..(1313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1374)..(1374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1388)..(1388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1392)..(1392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1398)..(1398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1412)..(1412)
<223> Selenocysteine

<400> 2098
Met Tyr Glu Arg His Lys Arg Arg Tyr Ser Leu Cys Asp Ile Ser Lys 
1               5                   10                  15      


Val Asp Arg Xaa Val Asp Val Val Leu Leu Lys Ile Asn Arg Glu Asn 
            20                  25                  30          


Trp Cys Xaa Ile Glu Pro Cys Pro Asp Ala Ala Ser Leu Leu Ala Ser 
        35                  40                  45              


Lys Gln Ser Pro Glu Cys Glu Asn Phe Leu Asp Val Gly Leu Gly Arg 
    50                  55                  60                  


Glu Cys Xaa Ser Lys Gln Gly Val Leu Lys Arg Glu Ser Gly Ser Asp 
65                  70                  75                  80  


Ser Asp Leu Phe His Ser Pro Ser Asp Asp Met Asp Ser Ile Ile Phe 
                85                  90                  95      


Pro Lys Pro Glu Glu Glu His Leu Ala Cys Asp Ile Xaa Gly Ser Ser 
            100                 105                 110         


Ser Ser Xaa Asp Asp Xaa Ala Ser Leu Asp Arg His Ser Ser His Gly 
        115                 120                 125             


Ser Asp Val Ser Leu Ser Gln Ile Leu Lys Pro Asn Arg Ser Arg Asp 
    130                 135                 140                 


Arg Gln Ser Leu Asp Gly Phe Tyr Ser His Gly Met Gly Ala Glu Gly 
145                 150                 155                 160 


Arg Glu Ser Glu Ser Glu Pro Ala Asp Pro Gly Asp Val Glu Glu Glu 
                165                 170                 175     


Glu Met Asp Ser Ile Xaa Glu Val Pro Ala Asn Cys Ser Val Leu Arg 
            180                 185                 190         


Ser Ser Met Arg Ser Leu Ser Pro Phe Arg Arg His Ser Trp Gly Pro 
        195                 200                 205             


Gly Lys Asn Ala Ala Ser Asp Ala Glu Met Asn His Arg Ser Phe Ser 
    210                 215                 220                 


Leu Glu Gly Leu Xaa Gly Gly Ala Gly Val Gly Asn Lys Pro Ser Ser 
225                 230                 235                 240 


Ser Leu Glu Val Ser Ser Ala Asn Ala Glu Glu Leu Arg His Pro Phe 
                245                 250                 255     


Ser Gly Glu Glu Arg Val Asp Ser Leu Val Ser Leu Ser Glu Glu Asp 
            260                 265                 270         


Leu Glu Ser Asp Gln Arg Glu His Arg Met Phe Asp Gln Gln Ile Cys 
        275                 280                 285             


His Arg Ser Lys Gln Gln Gly Phe Asn Tyr Cys Xaa Ser Ala Ile Ser 
    290                 295                 300                 


Ser Pro Leu Xaa Lys Ser Ile Ser Leu Met Xaa Ile Ser His Pro Gly 
305                 310                 315                 320 


Leu Asp Asn Ser Arg Pro Phe His Ser Xaa Phe His Asn Xaa Ser Ala 
                325                 330                 335     


Asn Leu Xaa Glu Ser Ile Xaa Glu Glu Asn Tyr Asn Phe Leu Pro His 
            340                 345                 350         


Ser Pro Ser Lys Lys Asp Ser Glu Trp Lys Ser Gly Xaa Lys Val Ser 
        355                 360                 365             


Arg Xaa Phe Ser Tyr Ile Lys Asn Lys Met Ser Ser Ser Lys Lys Ser 
    370                 375                 380                 


Lys Glu Lys Glu Lys Glu Lys Asp Lys Ile Lys Glu Lys Glu Lys Asp 
385                 390                 395                 400 


Ser Lys Asp Lys Glu Lys Asp Lys Lys Xaa Val Asn Gly His Xaa Phe 
                405                 410                 415     


Ser Ser Ile Pro Val Val Gly Pro Ile Ser Cys Ser Gln Cys Met Lys 
            420                 425                 430         


Pro Phe Xaa Asn Lys Asp Ala Tyr Xaa Cys Ala Asn Cys Ser Ala Phe 
        435                 440                 445             


Val His Lys Gly Cys Arg Glu Ser Leu Ala Ser Cys Ala Lys Val Lys 
    450                 455                 460                 


Met Lys Pro Lys Gly Ser Leu Gln Ala His Asp Xaa Ser Ser Leu Pro 
465                 470                 475                 480 


Xaa Val Ile Met Arg Asn Lys Pro Ser Gln Pro Lys Glu Arg Pro Arg 
                485                 490                 495     


Ser Ala Val Leu Leu Val Asp Glu Xaa Ala Xaa Xaa Pro Ile Phe Ala 
            500                 505                 510         


Asn Arg Arg Ser Gln Gln Ser Val Ser Leu Ser Lys Ser Val Ser Ile 
        515                 520                 525             


Gln Asn Ile Xaa Gly Val Gly Asn Asp Glu Asn Met Ser Asn Xaa Trp 
    530                 535                 540                 


Lys Phe Leu Ser His Ser Xaa Asp Ser Leu Asn Lys Ile Ser Lys Val 
545                 550                 555                 560 


Asn Glu Ser Xaa Glu Ser Leu Xaa Asp Glu Gly Val Gly Xaa Asp Met 
                565                 570                 575     


Asn Glu Gly Gln Leu Leu Gly Asp Phe Glu Ile Glu Ser Lys Gln Leu 
            580                 585                 590         


Glu Ala Glu Ser Trp Ser Arg Ile Ile Asp Ser Lys Phe Leu Lys Gln 
        595                 600                 605             


Gln Lys Lys Asp Val Val Lys Arg Gln Glu Val Ile Tyr Glu Leu Met 
    610                 615                 620                 


Gln Xaa Glu Phe His His Val Arg Xaa Leu Lys Ile Met Ser Gly Val 
625                 630                 635                 640 


Tyr Ser Gln Gly Met Met Ala Asp Leu Leu Phe Glu Gln Gln Met Val 
                645                 650                 655     


Glu Lys Leu Phe Pro Cys Leu Asp Glu Leu Ile Ser Ile His Ser Gln 
            660                 665                 670         


Phe Phe Gln Arg Ile Leu Glu Arg Lys Lys Glu Ser Leu Val Asp Lys 
        675                 680                 685             


Ser Glu Lys Asn Phe Leu Ile Lys Arg Ile Gly Asp Val Leu Val Asn 
    690                 695                 700                 


Gln Phe Ser Gly Glu Asn Ala Glu Arg Leu Lys Lys Xaa Tyr Gly Lys 
705                 710                 715                 720 


Phe Cys Gly Gln His Asn Gln Ser Val Asn Tyr Phe Lys Asp Leu Tyr 
                725                 730                 735     


Ala Lys Asp Lys Arg Phe Gln Ala Phe Val Lys Lys Lys Met Ser Ser 
            740                 745                 750         


Ser Val Val Arg Arg Leu Gly Ile Pro Glu Cys Ile Leu Leu Val Xaa 
        755                 760                 765             


Gln Arg Ile Xaa Lys Tyr Pro Val Leu Phe Gln Arg Ile Leu Gln Cys 
    770                 775                 780                 


Xaa Lys Asp Asn Glu Val Glu Gln Glu Asp Leu Ala Gln Ser Leu Ser 
785                 790                 795                 800 


Leu Val Lys Asp Val Ile Gly Ala Val Asp Ser Lys Val Ala Ser Tyr 
                805                 810                 815     


Glu Lys Lys Val Arg Leu Asn Glu Ile Tyr Xaa Lys Xaa Asp Ser Lys 
            820                 825                 830         


Ser Ile Met Arg Met Lys Ser Gly Gln Met Phe Ala Lys Glu Asp Leu 
        835                 840                 845             


Lys Arg Lys Lys Leu Val Arg Asp Gly Ser Val Phe Leu Lys Asn Ala 
    850                 855                 860                 


Ala Gly Arg Leu Lys Glu Val Gln Ala Val Leu Leu Xaa Asp Ile Leu 
865                 870                 875                 880 


Val Phe Leu Gln Glu Lys Asp Gln Lys Tyr Ile Phe Ala Ser Leu Asp 
                885                 890                 895     


Gln Lys Ser Xaa Val Ile Ser Leu Lys Lys Leu Ile Val Arg Glu Val 
            900                 905                 910         


Ala His Glu Glu Lys Gly Leu Phe Leu Ile Ser Met Gly Met Xaa Asp 
        915                 920                 925             


Pro Glu Met Val Glu Val His Ala Ser Ser Lys Glu Glu Arg Asn Ser 
    930                 935                 940                 


Trp Ile Gln Ile Ile Gln Asp Xaa Ile Asn Xaa Leu Asn Arg Asp Glu 
945                 950                 955                 960 


Asp Glu Gly Ile Pro Ser Glu Asn Glu Glu Glu Lys Lys Met Leu Asp 
                965                 970                 975     


Xaa Arg Ala Arg Glu Leu Lys Glu Gln Leu His Gln Lys Asp Gln Lys 
            980                 985                 990         


Ile Leu Leu Leu Leu Glu Glu Lys  Glu Met Ile Phe Arg  Asp Met Ala 
        995                 1000                 1005             


Glu Cys  Ser Xaa Pro Leu Pro  Glu Asp Cys Ser Pro  Xaa His Ser 
    1010                 1015                 1020             


Pro Arg  Val Leu Phe Arg Ser  Asn Xaa Glu Glu Ala  Leu Lys Gly 
    1025                 1030                 1035             


Gly Pro  Leu Met Lys Ser Ala  Ile Asn Glu Val Glu  Ile Leu Gln 
    1040                 1045                 1050             


Gly Leu  Val Ser Gly Asn Leu  Gly Gly Xaa Leu Gly  Pro Xaa Val 
    1055                 1060                 1065             


Ser Ser  Pro Ile Glu Gln Asp  Val Val Gly Pro Val  Ser Leu Pro 
    1070                 1075                 1080             


Arg Arg  Ala Glu Xaa Phe Gly  Gly Phe Asp Ser His  Gln Met Asn 
    1085                 1090                 1095             


Ala Ser  Lys Gly Gly Glu Lys  Glu Glu Gly Asp Asp  Gly Gln Asp 
    1100                 1105                 1110             


Leu Arg  Arg Xaa Glu Ser Asp  Ser Gly Leu Lys Lys  Gly Gly Asn 
    1115                 1120                 1125             


Ala Asn  Leu Val Phe Met Leu  Lys Arg Asn Ser Glu  Gln Val Val 
    1130                 1135                 1140             


Gln Ser  Val Val His Leu Tyr  Glu Leu Leu Ser Ala  Leu Gln Gly 
    1145                 1150                 1155             


Val Val  Leu Gln Gln Asp Ser  Tyr Ile Glu Asp Gln  Lys Leu Val 
    1160                 1165                 1170             


Leu Ser  Glu Arg Ala Leu Xaa  Arg Ser Leu Ser Arg  Pro Ser Ser 
    1175                 1180                 1185             


Leu Ile  Glu Gln Glu Lys Gln  Arg Ser Leu Glu Lys  Gln Arg Gln 
    1190                 1195                 1200             


Asp Leu  Ala Asn Leu Gln Lys  Gln Gln Ala Gln Tyr  Leu Glu Glu 
    1205                 1210                 1215             


Lys Arg  Arg Arg Glu Arg Glu  Trp Glu Ala Arg Glu  Arg Glu Leu 
    1220                 1225                 1230             


Arg Glu  Arg Glu Ala Leu Leu  Ala Gln Arg Glu Glu  Glu Val Gln 
    1235                 1240                 1245             


Gln Gly  Gln Gln Asp Leu Glu  Lys Glu Arg Glu Glu  Leu Gln Gln 
    1250                 1255                 1260             


Lys Lys  Gly Xaa Tyr Gln Tyr  Asp Leu Glu Arg Leu  Arg Ala Ala 
    1265                 1270                 1275             


Gln Lys  Gln Leu Glu Arg Glu  Gln Glu Gln Leu Arg  Arg Glu Ala 
    1280                 1285                 1290             


Glu Arg  Leu Ser Gln Arg Gln  Xaa Glu Arg Asp Leu  Cys Gln Val 
    1295                 1300                 1305             


Ser His  Pro His Xaa Lys Leu  Met Arg Ile Pro Ser  Phe Phe Pro 
    1310                 1315                 1320             


Ser Pro  Glu Glu Pro Pro Ser  Pro Ser Ala Pro Ser  Ile Ala Lys 
    1325                 1330                 1335             


Ser Gly  Ser Leu Asp Ser Glu  Leu Ser Val Ser Pro  Lys Arg Asn 
    1340                 1345                 1350             


Ser Ile  Ser Arg Xaa His Lys  Asp Lys Gly Pro Phe  His Ile Leu 
    1355                 1360                 1365             


Ser Ser  Xaa Ser Gln Xaa Asn  Lys Gly Pro Glu Gly  Gln Ser Gln 
    1370                 1375                 1380             


Ala Pro  Ala Ser Xaa Ser Ala  Ser Xaa Arg Leu Phe  Gly Leu Xaa 
    1385                 1390                 1395             


Lys Pro  Lys Glu Lys Lys Glu  Lys Lys Lys Lys Asn  Lys Xaa Ser 
    1400                 1405                 1410             


Arg Ser  Gln Pro Gly Asp Gly  Pro Ala Ser Glu Val  Ser Ala Glu 
    1415                 1420                 1425             


Gly Glu  Glu Ile Phe Cys 
    1430                 


<210> 2099
<211> 275
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<400> 2099
Pro Ser Asp Asp Met Asp Ser Ile Ile Phe Pro Lys Pro Glu Glu Glu 
1               5                   10                  15      


His Leu Ala Cys Asp Ile Xaa Gly Ser Ser Ser Ser Xaa Asp Asp Xaa 
            20                  25                  30          


Ala Ser Leu Asp Arg His Ser Ser His Gly Ser Asp Val Ser Leu Ser 
        35                  40                  45              


Gln Ile Leu Lys Pro Asn Arg Ser Arg Asp Arg Gln Ser Leu Asp Gly 
    50                  55                  60                  


Phe Tyr Ser His Gly Met Gly Ala Glu Gly Arg Glu Ser Glu Ser Glu 
65                  70                  75                  80  


Pro Ala Asp Pro Gly Asp Val Glu Glu Glu Glu Met Asp Ser Ile Xaa 
                85                  90                  95      


Glu Val Pro Ala Asn Cys Ser Val Leu Arg Ser Ser Met Arg Ser Leu 
            100                 105                 110         


Ser Pro Phe Arg Arg His Ser Trp Gly Pro Gly Lys Asn Ala Ala Ser 
        115                 120                 125             


Asp Ala Glu Met Asn His Arg Ser Ser Met Arg Val Leu Gly Asp Val 
    130                 135                 140                 


Val Arg Arg Pro Pro Ile His Arg Arg Ser Met Ser Trp Cys Pro Ser 
145                 150                 155                 160 


Gly Val Gln Tyr Ser Ala Gly Leu Ser Ala Asp Phe Asn Tyr Arg Ser 
                165                 170                 175     


Phe Ser Leu Glu Gly Leu Xaa Gly Gly Ala Gly Val Gly Asn Lys Pro 
            180                 185                 190         


Ser Ser Ser Leu Glu Val Ser Ser Ala Asn Ala Glu Glu Leu Arg His 
        195                 200                 205             


Pro Phe Ser Gly Glu Glu Arg Val Asp Ser Leu Val Ser Leu Ser Glu 
    210                 215                 220                 


Glu Asp Leu Glu Ser Asp Gln Arg Glu His Arg Met Phe Asp Gln Gln 
225                 230                 235                 240 


Ile Cys His Arg Ser Lys Gln Gln Gly Phe Asn Tyr Cys Xaa Ser Ala 
                245                 250                 255     


Ile Ser Ser Pro Leu Xaa Lys Ser Ile Ser Leu Met Xaa Ile Ser His 
            260                 265                 270         


Pro Gly Leu 
        275 


<210> 2100
<211> 385
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<400> 2100
Met Ala Ala Ala Xaa Ile Val His Asp Xaa Ser Glu Ala Val Glu Leu 
1               5                   10                  15      


Cys Pro Ala Tyr Gly Leu Tyr Leu Lys Pro Ile Xaa Lys Met Xaa Ile 
            20                  25                  30          


Ser Val Ala Leu Pro Gln Leu Lys Gln Pro Gly Lys Ser Ile Ser Asn 
        35                  40                  45              


Trp Glu Val Met Glu Arg Leu Lys Gly Met Val Gln Asn His Gln Phe 
    50                  55                  60                  


Ser Xaa Leu Arg Ile Ser Lys Ser Xaa Met Asp Phe Ile Arg Phe Glu 
65                  70                  75                  80  


Gly Glu Val Glu Asn Lys Ser Leu Val Lys Ser Phe Leu Ala Cys Leu 
                85                  90                  95      


Asp Gly Lys Xaa Ile Lys Leu Ser Gly Phe Ser Asp Ile Leu Lys Val 
            100                 105                 110         


Arg Ala Ala Glu Phe Lys Ile Asp Phe Pro Xaa Arg His Asp Trp Asp 
        115                 120                 125             


Ser Phe Phe Arg Asp Ala Lys Asp Met Asn Glu Xaa Leu Pro Gly Glu 
    130                 135                 140                 


Arg Pro Asp Xaa Ile His Leu Glu Gly Leu Pro Cys Lys Trp Phe Ala 
145                 150                 155                 160 


Leu Lys Glu Ser Gly Ser Glu Lys Pro Ser Glu Asp Val Leu Val Lys 
                165                 170                 175     


Val Phe Glu Lys Phe Gly Glu Ile Arg Asn Val Asp Ile Pro Met Leu 
            180                 185                 190         


Asp Pro Tyr Arg Glu Glu Met Xaa Gly Arg Asn Phe His Xaa Phe Ser 
        195                 200                 205             


Phe Gly Gly His Leu Asn Phe Glu Ala Tyr Val Gln Tyr Arg Glu Tyr 
    210                 215                 220                 


Met Gly Phe Ile Gln Ala Met Ser Ala Leu Arg Gly Met Lys Leu Met 
225                 230                 235                 240 


Tyr Lys Gly Glu Asp Gly Lys Ala Val Ala Cys Asn Ile Lys Val Ser 
                245                 250                 255     


Phe Asp Ser Xaa Lys His Leu Ser Asp Ala Ser Ile Lys Lys Arg Gln 
            260                 265                 270         


Leu Glu Arg Gln Lys Leu Gln Glu Leu Glu Gln Gln Arg Glu Glu Gln 
        275                 280                 285             


Lys Arg Arg Glu Lys Glu Ala Glu Glu Arg Gln Arg Ala Glu Glu Arg 
    290                 295                 300                 


Lys Gln Lys Glu Leu Glu Glu Leu Glu Arg Glu Arg Lys Arg Glu Glu 
305                 310                 315                 320 


Lys Leu Arg Lys Arg Glu Gln Lys Gln Arg Asp Arg Glu Leu Arg Arg 
                325                 330                 335     


Asn Gln Lys Lys Leu Glu Lys Leu Gln Ala Glu Glu Gln Lys Gln Leu 
            340                 345                 350         


Gln Glu Lys Ile Lys Leu Glu Glu Arg Lys Leu Leu Leu Ala Gln Arg 
        355                 360                 365             


Asn Leu Gln Ser Ile Arg Leu Ile Ala Glu Leu Leu Ser Arg Ala Lys 
    370                 375                 380                 


Leu 
385 


<210> 2101
<211> 446
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<400> 2101
Met Ala Ala Ala Xaa Ile Val His Asp Xaa Ser Glu Ala Val Glu Leu 
1               5                   10                  15      


Cys Pro Ala Tyr Gly Leu Tyr Leu Lys Pro Ile Xaa Lys Met Xaa Ile 
            20                  25                  30          


Ser Val Ala Leu Pro Gln Leu Lys Gln Pro Gly Lys Ser Ile Ser Asn 
        35                  40                  45              


Trp Glu Val Met Glu Arg Leu Lys Gly Met Val Gln Asn His Gln Phe 
    50                  55                  60                  


Ser Xaa Leu Arg Ile Ser Lys Ser Xaa Met Asp Phe Ile Arg Phe Glu 
65                  70                  75                  80  


Gly Glu Val Glu Asn Lys Ser Leu Val Lys Ser Phe Leu Ala Cys Leu 
                85                  90                  95      


Asp Gly Lys Xaa Ile Lys Leu Ser Gly Phe Ser Asp Ile Leu Lys Val 
            100                 105                 110         


Arg Ala Ala Glu Phe Lys Ile Asp Phe Pro Xaa Arg His Asp Trp Asp 
        115                 120                 125             


Ser Phe Phe Arg Asp Ala Lys Asp Met Asn Glu Xaa Leu Pro Gly Glu 
    130                 135                 140                 


Arg Pro Asp Xaa Ile His Leu Glu Gly Leu Pro Cys Lys Trp Phe Ala 
145                 150                 155                 160 


Leu Lys Glu Ser Gly Ser Glu Lys Pro Ser Glu Asp Val Leu Val Lys 
                165                 170                 175     


Val Phe Glu Lys Phe Gly Glu Ile Arg Asn Val Asp Ile Pro Met Leu 
            180                 185                 190         


Asp Pro Tyr Arg Glu Glu Met Xaa Gly Arg Asn Phe His Xaa Phe Ser 
        195                 200                 205             


Phe Gly Gly His Leu Asn Phe Glu Ala Tyr Val Gln Tyr Arg Glu Tyr 
    210                 215                 220                 


Met Gly Phe Ile Gln Ala Met Ser Ala Leu Arg Gly Met Lys Leu Met 
225                 230                 235                 240 


Tyr Lys Gly Glu Asp Gly Lys Ala Val Ala Cys Asn Ile Lys Val Ser 
                245                 250                 255     


Phe Asp Ser Xaa Lys His Leu Ser Asp Ala Ser Ile Lys Lys Arg Gln 
            260                 265                 270         


Leu Glu Arg Gln Lys Leu Gln Glu Leu Glu Gln Gln Arg Glu Glu Gln 
        275                 280                 285             


Lys Arg Arg Glu Lys Glu Ala Glu Glu Arg Gln Arg Ala Glu Glu Arg 
    290                 295                 300                 


Lys Gln Lys Glu Leu Glu Glu Leu Glu Arg Glu Arg Lys Arg Glu Glu 
305                 310                 315                 320 


Lys Leu Arg Lys Arg Glu Gln Lys Gln Arg Asp Arg Glu Leu Arg Arg 
                325                 330                 335     


Asn Gln Lys Lys Leu Glu Lys Leu Gln Ala Glu Glu Gln Lys Gln Leu 
            340                 345                 350         


Gln Glu Lys Ile Lys Leu Glu Glu Arg Lys Leu Leu Leu Ala Gln Arg 
        355                 360                 365             


Asn Leu Gln Ser Ile Arg Leu Ile Ala Glu Leu Leu Ser Arg Ala Lys 
    370                 375                 380                 


Val Pro Gly Gly Ser Leu Cys Ser Arg Gln Pro Arg Pro Gly Cys Pro 
385                 390                 395                 400 


Gln Cys Pro Pro Leu Lys Cys Gly Arg Arg His Gly Ala Val Ser Pro 
                405                 410                 415     


Pro Ala Ala Ala Val Ala Xaa Lys Pro Ala Leu Met Pro Arg Met Xaa 
            420                 425                 430         


Ala Pro Ser Arg Glu Gly Val Ala Leu Val Cys Arg Ser Arg 
        435                 440                 445     


<210> 2102
<211> 695
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<400> 2102
Met Ala Ala Ala Xaa Ile Val His Asp Xaa Ser Glu Ala Val Glu Leu 
1               5                   10                  15      


Cys Pro Ala Tyr Gly Leu Tyr Leu Lys Pro Ile Xaa Lys Met Xaa Ile 
            20                  25                  30          


Ser Val Ala Leu Pro Gln Leu Lys Gln Pro Gly Lys Ser Ile Ser Asn 
        35                  40                  45              


Trp Glu Val Met Glu Arg Leu Lys Gly Met Val Gln Asn His Gln Phe 
    50                  55                  60                  


Ser Xaa Leu Arg Ile Ser Lys Ser Xaa Met Asp Phe Ile Arg Phe Glu 
65                  70                  75                  80  


Gly Glu Val Glu Asn Lys Ser Leu Val Lys Ser Phe Leu Ala Cys Leu 
                85                  90                  95      


Asp Gly Lys Xaa Ile Lys Leu Ser Gly Phe Ser Asp Ile Leu Lys Val 
            100                 105                 110         


Arg Ala Ala Glu Phe Lys Ile Asp Phe Pro Xaa Arg His Asp Trp Asp 
        115                 120                 125             


Ser Phe Phe Arg Asp Ala Lys Asp Met Asn Glu Xaa Leu Pro Gly Glu 
    130                 135                 140                 


Arg Pro Asp Xaa Ile His Leu Glu Gly Leu Pro Cys Lys Trp Phe Ala 
145                 150                 155                 160 


Leu Lys Glu Ser Gly Ser Glu Lys Pro Ser Glu Asp Val Leu Val Lys 
                165                 170                 175     


Val Phe Glu Lys Phe Gly Glu Ile Arg Asn Val Asp Ile Pro Met Leu 
            180                 185                 190         


Asp Pro Tyr Arg Glu Glu Met Xaa Gly Arg Asn Phe His Xaa Phe Ser 
        195                 200                 205             


Phe Gly Gly His Leu Asn Phe Glu Ala Tyr Val Gln Tyr Arg Glu Tyr 
    210                 215                 220                 


Met Gly Phe Ile Gln Ala Met Ser Ala Leu Arg Gly Met Lys Leu Met 
225                 230                 235                 240 


Tyr Lys Gly Glu Asp Gly Lys Ala Val Ala Cys Asn Ile Lys Val Ser 
                245                 250                 255     


Phe Asp Ser Xaa Lys His Leu Ser Asp Ala Ser Ile Lys Lys Arg Gln 
            260                 265                 270         


Leu Glu Arg Gln Lys Leu Gln Glu Leu Glu Gln Gln Arg Glu Glu Gln 
        275                 280                 285             


Lys Arg Arg Glu Lys Glu Ala Glu Glu Arg Gln Arg Ala Glu Glu Arg 
    290                 295                 300                 


Lys Gln Lys Glu Leu Glu Glu Leu Glu Arg Glu Arg Lys Arg Glu Glu 
305                 310                 315                 320 


Lys Leu Arg Lys Arg Glu Gln Lys Gln Arg Asp Arg Glu Leu Arg Arg 
                325                 330                 335     


Asn Gln Lys Lys Leu Glu Lys Leu Gln Ala Glu Glu Gln Lys Gln Leu 
            340                 345                 350         


Gln Glu Lys Ile Lys Leu Glu Glu Arg Lys Leu Leu Leu Ala Gln Arg 
        355                 360                 365             


Asn Leu Gln Ser Ile Arg Leu Ile Ala Glu Leu Leu Ser Arg Ala Lys 
    370                 375                 380                 


Ala Val Lys Leu Arg Glu Gln Glu Gln Lys Glu Glu Lys Leu Arg Leu 
385                 390                 395                 400 


Gln Gln Gln Glu Glu Arg Arg Arg Leu Gln Glu Ala Glu Leu Arg Arg 
                405                 410                 415     


Val Glu Glu Glu Lys Glu Arg Ala Leu Gly Leu Gln Arg Lys Glu Arg 
            420                 425                 430         


Glu Leu Arg Glu Arg Leu Leu Ser Ile Leu Leu Ser Lys Lys Pro Asp 
        435                 440                 445             


Asp Ser His Xaa His Asp Glu Leu Gly Val Ala His Ala Asp Leu Leu 
    450                 455                 460                 


Gln Pro Val Leu Asp Ile Leu Gln Xaa Val Ser Ser Gly Cys Val Ser 
465                 470                 475                 480 


Ala Xaa Xaa Leu His Pro Leu Gly Gly Gln Pro Pro Ala Gly Ala Pro 
                485                 490                 495     


Lys Glu Ser Pro Ala His Pro Glu Ala Asp Gly Ala Pro Lys Ser Val 
            500                 505                 510         


Asn Gly Ser Val Ala Glu Glu Ala Pro Cys Lys Glu Val Gln Ser Ser 
        515                 520                 525             


Cys Arg Val Val Pro Glu Asp Gly Ser Pro Glu Lys Arg Cys Pro Gly 
    530                 535                 540                 


Gly Val Leu Ser Cys Ile Pro Asp Asn Asn Gln Gln Pro Lys Gly Ile 
545                 550                 555                 560 


Pro Ala Cys Glu Gln Asn Val Ser Arg Lys Asp Xaa Arg Ser Glu Gln 
                565                 570                 575     


Asp Lys Cys Asn Arg Glu Pro Ser Lys Gly Arg Gly Arg Ala Xaa Gly 
            580                 585                 590         


Asp Gly Leu Ala Asp Arg His Lys Arg Glu Arg Ser Arg Ala Arg Arg 
        595                 600                 605             


Ala Ser Ser Arg Glu Asp Gly Arg Pro Arg Lys Glu Arg Arg Pro His 
    610                 615                 620                 


Lys Lys His Ala Tyr Lys Asp Asp Ser Pro Arg Arg Arg Ser Xaa Ser 
625                 630                 635                 640 


Pro Asp His Xaa Arg Ser Arg Arg Ser His Ser Lys Asp Arg His Arg 
                645                 650                 655     


Arg Glu Arg Ser Arg Glu Arg Arg Gly Ser Ala Ser Arg Lys His Ser 
            660                 665                 670         


Arg His Arg Arg Arg Ser Glu Arg Ser Arg Ser Arg Ser Pro Ser Arg 
        675                 680                 685             


His Arg Ser Xaa Trp Asn Arg 
    690                 695 


<210> 2103
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<400> 2103
Met Ser Glu Lys Val Asp Trp Leu Gln Ser Gln Asn Gly Val Cys Lys 
1               5                   10                  15      


Val Asp Val Tyr Ser Pro Gly Asp Asn Gln Ala Gln Asp Trp Lys Met 
            20                  25                  30          


Asp Xaa Ser Xaa Asp Pro Val Arg Val Leu Ser Trp Leu Arg Arg Asp 
        35                  40                  45              


Leu Glu Lys Ser Xaa Ala Glu Phe Gln Asp Val Arg Phe Lys Pro Gly 
    50                  55                  60                  


Glu Ser Phe Gly Gly Glu Xaa Ser Asn Ser Gly Asp Pro His Lys Gly 
65                  70                  75                  80  


Phe Ser Val Asp Tyr Tyr Asn Xaa Xaa Xaa Lys Gly Xaa Pro Glu Arg 
                85                  90                  95      


<210> 2104
<211> 162
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<400> 2104
Met Ser Glu Lys Val Asp Trp Leu Gln Ser Gln Asn Gly Val Cys Lys 
1               5                   10                  15      


Val Asp Val Tyr Ser Pro Gly Asp Asn Gln Ala Gln Asp Trp Lys Met 
            20                  25                  30          


Asp Xaa Ser Xaa Asp Pro Val Arg Val Leu Ser Trp Leu Arg Arg Asp 
        35                  40                  45              


Leu Glu Lys Ser Xaa Ala Glu Phe Gln Asp Val Arg Phe Lys Pro Gly 
    50                  55                  60                  


Glu Ser Phe Gly Gly Glu Xaa Ser Asn Ser Gly Asp Pro His Lys Gly 
65                  70                  75                  80  


Phe Ser Val Asp Tyr Tyr Asn Xaa Xaa Xaa Lys Gly Xaa Pro Glu Arg 
                85                  90                  95      


Leu His Phe Glu Met Xaa His Lys Glu Ile Pro Cys Gln Gly Pro Arg 
            100                 105                 110         


Ala Gln Leu Gly Asn Gly Ser Ser Val Asp Glu Val Ser Phe Tyr Ala 
        115                 120                 125             


Asn Arg Leu Xaa Asn Leu Val Ile Ala Met Ala Arg Lys Glu Ile Asn 
    130                 135                 140                 


Glu Lys Ile Asp Gly Ser Glu Asn Lys Cys Val Tyr Gln Ser Leu Tyr 
145                 150                 155                 160 


Met Gly 
        


<210> 2105
<211> 853
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<400> 2105
Met Ser Glu Lys Val Asp Trp Leu Gln Ser Gln Asn Gly Val Cys Lys 
1               5                   10                  15      


Val Asp Val Tyr Ser Pro Gly Asp Asn Gln Ala Gln Asp Trp Lys Met 
            20                  25                  30          


Asp Xaa Ser Xaa Asp Pro Val Arg Val Leu Ser Trp Leu Arg Arg Asp 
        35                  40                  45              


Leu Glu Lys Ser Xaa Ala Glu Phe Gln Asp Val Arg Phe Lys Pro Gly 
    50                  55                  60                  


Glu Ser Phe Gly Gly Glu Xaa Ser Asn Ser Gly Asp Pro His Lys Gly 
65                  70                  75                  80  


Phe Ser Val Asp Tyr Tyr Asn Xaa Xaa Xaa Lys Gly Xaa Pro Glu Arg 
                85                  90                  95      


Leu His Phe Glu Met Xaa His Lys Glu Ile Pro Cys Gln Gly Pro Arg 
            100                 105                 110         


Ala Gln Leu Gly Asn Gly Ser Ser Val Asp Glu Val Ser Phe Tyr Ala 
        115                 120                 125             


Asn Arg Leu Xaa Asn Leu Val Ile Ala Met Ala Arg Lys Glu Ile Asn 
    130                 135                 140                 


Glu Lys Ile Asp Gly Ser Glu Asn Lys Cys Val Tyr Gln Ser Leu Tyr 
145                 150                 155                 160 


Met Gly Asn Glu Pro Xaa Pro Xaa Lys Ser Leu Ser Lys Ile Ala Ser 
                165                 170                 175     


Glu Leu Val Asn Glu Xaa Val Ser Ala Cys Ser Arg Asn Ala Ala Pro 
            180                 185                 190         


Asp Lys Ala Pro Gly Ser Gly Asp Arg Val Ser Gly Ser Ser Gln Ser 
        195                 200                 205             


Pro Pro Asn Leu Lys Tyr Lys Ser Xaa Leu Lys Ile Lys Glu Ser Xaa 
    210                 215                 220                 


Lys Glu Arg Gln Gly Pro Asp Asp Lys Pro Pro Ser Lys Lys Ser Phe 
225                 230                 235                 240 


Phe Tyr Lys Glu Val Phe Glu Ser Arg Asn Gly Asp Tyr Ala Arg Glu 
                245                 250                 255     


Gly Gly Arg Phe Phe Pro Arg Glu Arg Lys Arg Phe Arg Gly Gln Glu 
            260                 265                 270         


Arg Pro Asp Asp Phe Xaa Ala Ser Val Ser Glu Gly Ile Met Xaa Tyr 
        275                 280                 285             


Ala Asn Ser Val Val Ser Asp Met Met Val Ser Ile Met Lys Xaa Leu 
    290                 295                 300                 


Lys Ile Gln Val Lys Asp Xaa Xaa Ile Ala Xaa Ile Leu Leu Lys Lys 
305                 310                 315                 320 


Val Leu Leu Lys His Ala Lys Glu Val Val Ser Asp Leu Ile Asp Ser 
                325                 330                 335     


Phe Leu Arg Asn Leu His Ser Val Xaa Gly Xaa Leu Met Xaa Asp Xaa 
            340                 345                 350         


Gln Phe Val Ser Ala Val Lys Arg Xaa Val Phe Ser His Gly Ser Gln 
        355                 360                 365             


Lys Ala Xaa Asp Ile Met Asp Ala Met Leu Arg Lys Leu Tyr Asn Val 
    370                 375                 380                 


Met Phe Ala Lys Lys Val Pro Glu His Val Arg Lys Ala Gln Asp Lys 
385                 390                 395                 400 


Ala Glu Ser Tyr Ser Leu Ile Ser Met Lys Gly Met Gly Asp Pro Lys 
                405                 410                 415     


Asn Arg Asn Val Asn Phe Ala Met Lys Ser Glu Xaa Lys Leu Arg Glu 
            420                 425                 430         


Lys Met Tyr Ser Glu Pro Lys Ser Glu Glu Glu Xaa Cys Ala Lys Xaa 
        435                 440                 445             


Leu Gly Glu His Ile Ile Lys Glu Gly Leu Xaa Leu Trp His Lys Xaa 
    450                 455                 460                 


Gln Gln Lys Glu Cys Lys Ser Leu Gly Phe Gln His Ala Ala Phe Glu 
465                 470                 475                 480 


Ala Pro Asn Xaa Gln Arg Lys Pro Ala Ser Asp Ile Ser Phe Glu Tyr 
                485                 490                 495     


Pro Glu Asp Ile Gly Asn Leu Ser Leu Pro Pro Tyr Pro Pro Glu Lys 
            500                 505                 510         


Pro Glu Asn Phe Met Tyr Asp Ser Asp Ser Trp Ala Glu Asp Leu Ile 
        515                 520                 525             


Val Ser Ala Leu Leu Leu Ile Gln Tyr His Leu Ala Gln Gly Gly Arg 
    530                 535                 540                 


Arg Asp Ala Arg Ser Phe Val Glu Ala Ala Gly Xaa Xaa Asn Phe Pro 
545                 550                 555                 560 


Ala Asn Glu Pro Pro Val Ala Pro Asp Glu Ser Cys Leu Lys Ser Ala 
                565                 570                 575     


Pro Ile Val Gly Asp Gln Glu Gln Ala Glu Lys Lys Asp Leu Arg Ser 
            580                 585                 590         


Val Phe Phe Asn Phe Ile Arg Asn Leu Leu Ser Glu Xaa Ile Phe Lys 
        595                 600                 605             


Arg Asp Gln Ser Pro Glu Pro Lys Val Pro Glu Gln Pro Val Lys Glu 
    610                 615                 620                 


Asp Arg Lys Leu Cys Glu Arg Pro Leu Ala Ser Ser Pro Pro Arg Leu 
625                 630                 635                 640 


Tyr Glu Asp Asp Glu Xaa Pro Gly Ala Leu Ser Gly Leu Xaa Lys Met 
                645                 650                 655     


Ala Val Ser Gln Ile Asp Gly His Met Ser Gly Gln Met Val Glu His 
            660                 665                 670         


Leu Met Asn Ser Val Met Lys Leu Cys Val Ile Ile Ala Lys Ser Cys 
        675                 680                 685             


Asp Ala Ser Leu Ala Glu Leu Gly Asp Asp Lys Ser Gly Asp Ala Ser 
    690                 695                 700                 


Arg Leu Xaa Ser Ala Phe Pro Asp Ser Leu Tyr Glu Cys Leu Pro Ala 
705                 710                 715                 720 


Lys Gly Xaa Gly Ser Ala Glu Ala Val Leu Gln Asn Ala Tyr Gln Ala 
                725                 730                 735     


Ile His Asn Glu Met Arg Gly Xaa Ser Gly Gln Pro Pro Glu Gly Cys 
            740                 745                 750         


Ala Ala Pro Xaa Val Ile Val Ser Asn His Asn Leu Xaa Asp Xaa Val 
        755                 760                 765             


Gln Asn Lys Gln Leu Gln Ala Val Leu Gln Trp Val Ala Ala Ser Glu 
    770                 775                 780                 


Leu Asn Val Pro Ile Leu Tyr Phe Ala Gly Asp Asp Glu Gly Ile Gln 
785                 790                 795                 800 


Glu Lys Leu Leu Gln Leu Ser Ala Ala Ala Val Asp Lys Gly Cys Ser 
                805                 810                 815     


Val Gly Glu Val Leu Gln Ser Val Leu Arg Tyr Glu Lys Glu Arg Gln 
            820                 825                 830         


Leu Asn Glu Ala Val Gly Asn Val Xaa Pro Leu Gln Leu Leu Asp Trp 
        835                 840                 845             


Leu Met Val Asn Leu 
    850             


<210> 2106
<211> 854
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<400> 2106
Met Met Ala Tyr Ser Asp Xaa Xaa Met Met Ser Asp Asp Ile Asp Trp 
1               5                   10                  15      


Leu Arg Ser His Arg Gly Val Cys Lys Val Asp Leu Tyr Asn Pro Glu 
            20                  25                  30          


Gly Gln Gln Asp Gln Asp Arg Lys Val Ile Cys Phe Val Asp Val Ser 
        35                  40                  45              


Xaa Leu Asn Val Glu Asp Lys Asp Tyr Lys Asp Ala Ala Ser Ser Ser 
    50                  55                  60                  


Ser Glu Gly Asn Leu Asn Leu Gly Ser Leu Glu Glu Lys Glu Ile Ile 
65                  70                  75                  80  


Val Ile Lys Asp Xaa Glu Lys Lys Asp Gln Ser Lys Xaa Glu Gly Ser 
                85                  90                  95      


Val Cys Leu Phe Lys Gln Ala Pro Ser Asp Pro Val Ser Val Leu Asn 
            100                 105                 110         


Trp Leu Leu Ser Asp Leu Gln Lys Tyr Ala Leu Gly Phe Gln His Ala 
        115                 120                 125             


Leu Ser Pro Ser Xaa Ser Xaa Cys Lys His Lys Val Gly Asp Xaa Glu 
    130                 135                 140                 


Gly Glu Tyr His Arg Ala Ser Ser Glu Asn Cys Tyr Ser Val Tyr Ala 
145                 150                 155                 160 


Asp Gln Val Asn Ile Asp Tyr Leu Met Asn Arg Pro Gln Asn Leu Arg 
                165                 170                 175     


Leu Glu Met Xaa Ala Ala Lys Asn Xaa Asn Asn Asn Gln Ser Pro Ser 
            180                 185                 190         


Ala Pro Pro Ala Lys Pro Pro Ser Xaa Gln Arg Ala Val Ile Ser Pro 
        195                 200                 205             


Asp Gly Glu Cys Ser Ile Asp Asp Leu Ser Phe Tyr Val Asn Arg Leu 
    210                 215                 220                 


Ser Ser Leu Val Ile Gln Met Ala His Lys Glu Ile Lys Glu Lys Leu 
225                 230                 235                 240 


Glu Gly Lys Ser Lys Cys Leu His His Ser Ile Cys Pro Ser Pro Gly 
                245                 250                 255     


Asn Lys Glu Arg Ile Ser Pro Arg Xaa Pro Ala Ser Lys Ile Ala Ser 
            260                 265                 270         


Glu Met Ala Tyr Glu Ala Val Glu Leu Xaa Ala Ala Glu Met Arg Gly 
        275                 280                 285             


Xaa Gly Glu Glu Ser Arg Glu Gly Gly Gln Lys Ser Phe Leu Tyr Ser 
    290                 295                 300                 


Glu Leu Ser Asn Lys Ser Lys Ser Gly Asp Lys Gln Met Ser Gln Arg 
305                 310                 315                 320 


Glu Ser Lys Glu Phe Ala Asp Ser Ile Ser Lys Gly Leu Met Val Tyr 
                325                 330                 335     


Ala Asn Gln Val Ala Ser Asp Met Met Val Ser Leu Met Lys Xaa Leu 
            340                 345                 350         


Lys Val His Ser Ser Gly Lys Pro Ile Pro Ala Ser Val Val Leu Lys 
        355                 360                 365             


Arg Val Leu Leu Arg His Xaa Lys Glu Ile Val Ser Asp Leu Ile Asp 
    370                 375                 380                 


Ser Cys Met Lys Asn Leu His Asn Ile Xaa Gly Val Leu Met Xaa Asp 
385                 390                 395                 400 


Ser Asp Phe Val Ser Ala Val Lys Arg Asn Leu Phe Asn Gln Trp Lys 
                405                 410                 415     


Gln Asn Ala Xaa Asp Ile Met Glu Ala Met Leu Lys Arg Leu Val Ser 
            420                 425                 430         


Ala Leu Ile Gly Glu Glu Lys Glu Xaa Lys Ser Gln Ser Leu Ser Tyr 
        435                 440                 445             


Ala Ser Leu Lys Ala Gly Ser His Asp Pro Lys Cys Arg Asn Gln Ser 
    450                 455                 460                 


Leu Glu Phe Ser Xaa Met Lys Ala Glu Met Lys Glu Arg Asp Lys Gly 
465                 470                 475                 480 


Lys Met Lys Ser Asp Pro Cys Lys Ser Leu Xaa Ser Ala Glu Lys Val 
                485                 490                 495     


Gly Glu His Ile Leu Lys Glu Gly Leu Xaa Ile Trp Asn Gln Lys Gln 
            500                 505                 510         


Gly Asn Ser Cys Lys Val Ala Xaa Lys Ala Cys Ser Asn Lys Asp Glu 
        515                 520                 525             


Lys Gly Glu Lys Ile Asn Ala Ser Xaa Asp Ser Leu Ala Lys Asp Leu 
    530                 535                 540                 


Ile Val Ser Ala Leu Lys Leu Ile Gln Tyr His Leu Xaa Gln Gln Xaa 
545                 550                 555                 560 


Lys Gly Lys Asp Xaa Cys Glu Glu Asp Cys Pro Gly Ser Xaa Met Gly 
                565                 570                 575     


Tyr Met Ala Gln Ser Xaa Gln Tyr Glu Lys Cys Gly Gly Gly Gln Ser 
            580                 585                 590         


Ala Lys Ala Leu Ser Val Lys Gln Leu Glu Ser His Arg Ala Pro Gly 
        595                 600                 605             


Pro Ser Xaa Cys Gln Lys Glu Asn Gln His Leu Asp Ser Gln Lys Met 
    610                 615                 620                 


Asp Met Ser Asn Ile Val Leu Met Leu Ile Gln Lys Leu Leu Asn Glu 
625                 630                 635                 640 


Asn Pro Phe Lys Cys Glu Asp Pro Cys Glu Gly Glu Asn Lys Cys Ser 
                645                 650                 655     


Glu Pro Arg Ala Ser Lys Ala Ala Ser Met Ser Asn Arg Ser Asp Lys 
            660                 665                 670         


Ala Glu Glu Gln Cys Gln Glu His Gln Glu Leu Asp Cys Xaa Ser Gly 
        675                 680                 685             


Met Lys Gln Ala Asn Gly Gln Phe Ile Asp Lys Leu Val Glu Ser Val 
    690                 695                 700                 


Met Lys Leu Cys Leu Ile Met Ala Lys Tyr Ser Asn Asp Gly Ala Ala 
705                 710                 715                 720 


Leu Ala Glu Leu Glu Glu Gln Ala Ala Ser Ala Asn Lys Pro Asn Phe 
                725                 730                 735     


Arg Gly Xaa Arg Cys Ile His Ser Gly Ala Met Pro Gln Asn Tyr Gln 
            740                 745                 750         


Asp Ser Leu Gly His Glu Val Ile Val Asn Asn Gln Cys Ser Xaa Asn 
        755                 760                 765             


Ser Leu Gln Lys Gln Leu Gln Ala Val Leu Gln Trp Ile Ala Ala Ser 
    770                 775                 780                 


Gln Phe Asn Val Pro Met Leu Tyr Phe Met Gly Asp Lys Asp Gly Gln 
785                 790                 795                 800 


Leu Glu Lys Leu Pro Gln Val Ser Ala Lys Ala Ala Glu Lys Gly Tyr 
                805                 810                 815     


Ser Val Gly Gly Leu Leu Gln Glu Val Met Lys Phe Ala Lys Glu Arg 
            820                 825                 830         


Gln Pro Asp Glu Ala Val Gly Lys Val Ala Arg Lys Gln Leu Leu Asp 
        835                 840                 845             


Trp Leu Leu Ala Asn Leu 
    850                 


<210> 2107
<211> 213
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<400> 2107
Met Ser Asp Asp Ile Asp Trp Leu Arg Ser His Arg Gly Val Cys Lys 
1               5                   10                  15      


Val Asp Leu Tyr Asn Pro Glu Gly Gln Gln Asp Gln Asp Arg Lys Val 
            20                  25                  30          


Ile Cys Phe Val Asp Val Ser Xaa Leu Asn Val Glu Asp Lys Asp Tyr 
        35                  40                  45              


Lys Asp Ala Ala Ser Ser Ser Ser Glu Gly Asn Leu Asn Leu Gly Ser 
    50                  55                  60                  


Leu Glu Glu Lys Glu Ile Ile Val Ile Lys Asp Xaa Glu Lys Lys Asp 
65                  70                  75                  80  


Gln Ser Lys Xaa Glu Gly Ser Val Cys Leu Phe Lys Gln Ala Pro Ser 
                85                  90                  95      


Asp Pro Val Ser Val Leu Asn Trp Leu Leu Ser Asp Leu Gln Lys Tyr 
            100                 105                 110         


Ala Leu Gly Phe Gln His Ala Leu Ser Pro Ser Xaa Ser Xaa Cys Lys 
        115                 120                 125             


His Lys Val Gly Asp Xaa Glu Gly Glu Tyr His Arg Ala Ser Ser Glu 
    130                 135                 140                 


Asn Cys Tyr Ser Val Tyr Ala Asp Gln Val Asn Ile Asp Tyr Leu Met 
145                 150                 155                 160 


Asn Arg Pro Gln Asn Leu Arg Leu Glu Met Xaa Ala Ala Lys Asn Xaa 
                165                 170                 175     


Asn Asn Asn Gln Asn Xaa Cys Glu Glu Asp Cys Pro Gly Ser Xaa Met 
            180                 185                 190         


Gly Tyr Met Ala Gln Ser Xaa Gln Tyr Glu Lys Cys Gly Gly Gly Gln 
        195                 200                 205             


Ser Ala Lys Ala Leu 
    210             


<210> 2108
<211> 254
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<400> 2108
Met Ser Asp Asp Ile Asp Trp Leu Arg Ser His Arg Gly Val Cys Lys 
1               5                   10                  15      


Val Asp Leu Tyr Asn Pro Glu Gly Gln Gln Asp Gln Asp Arg Lys Val 
            20                  25                  30          


Ile Cys Phe Val Asp Val Ser Xaa Leu Asn Val Glu Asp Lys Asp Tyr 
        35                  40                  45              


Lys Asp Ala Ala Ser Ser Ser Ser Glu Gly Asn Leu Asn Leu Gly Ser 
    50                  55                  60                  


Leu Glu Glu Lys Glu Ile Ile Val Ile Lys Asp Xaa Glu Lys Lys Asp 
65                  70                  75                  80  


Gln Ser Lys Xaa Glu Gly Ser Val Cys Leu Phe Lys Gln Ala Pro Ser 
                85                  90                  95      


Asp Pro Val Ser Val Leu Asn Trp Leu Leu Ser Asp Leu Gln Lys Tyr 
            100                 105                 110         


Ala Leu Gly Phe Gln His Ala Leu Ser Pro Ser Xaa Ser Xaa Cys Lys 
        115                 120                 125             


His Lys Val Gly Asp Xaa Glu Gly Glu Tyr His Arg Ala Ser Ser Glu 
    130                 135                 140                 


Asn Cys Tyr Ser Val Tyr Ala Asp Gln Val Asn Ile Asp Tyr Leu Met 
145                 150                 155                 160 


Asn Arg Pro Gln Asn Leu Arg Leu Glu Met Xaa Ala Ala Lys Asn Xaa 
                165                 170                 175     


Asn Asn Asn Gln Ser Pro Ser Ala Pro Pro Ala Lys Pro Pro Ser Xaa 
            180                 185                 190         


Gln Arg Ala Val Ile Ser Pro Asp Gly Glu Cys Ser Ile Asp Asp Leu 
        195                 200                 205             


Ser Phe Tyr Val Asn Arg Leu Ser Ser Leu Val Ile Gln Met Ala His 
    210                 215                 220                 


Lys Glu Ile Lys Glu Lys Leu Glu Gly Lys Ser Lys Cys Leu His His 
225                 230                 235                 240 


Ser Ile Cys Pro Ser Pro Gly Asn Lys Glu Arg Ile Ser Pro 
                245                 250                 


<210> 2109
<211> 845
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<400> 2109
Met Ser Asp Asp Ile Asp Trp Leu Arg Ser His Arg Gly Val Cys Lys 
1               5                   10                  15      


Val Asp Leu Tyr Asn Pro Glu Gly Gln Gln Asp Gln Asp Arg Lys Val 
            20                  25                  30          


Ile Cys Phe Val Asp Val Ser Xaa Leu Asn Val Glu Asp Lys Asp Tyr 
        35                  40                  45              


Lys Asp Ala Ala Ser Ser Ser Ser Glu Gly Asn Leu Asn Leu Gly Ser 
    50                  55                  60                  


Leu Glu Glu Lys Glu Ile Ile Val Ile Lys Asp Xaa Glu Lys Lys Asp 
65                  70                  75                  80  


Gln Ser Lys Xaa Glu Gly Ser Val Cys Leu Phe Lys Gln Ala Pro Ser 
                85                  90                  95      


Asp Pro Val Ser Val Leu Asn Trp Leu Leu Ser Asp Leu Gln Lys Tyr 
            100                 105                 110         


Ala Leu Gly Phe Gln His Ala Leu Ser Pro Ser Xaa Ser Xaa Cys Lys 
        115                 120                 125             


His Lys Val Gly Asp Xaa Glu Gly Glu Tyr His Arg Ala Ser Ser Glu 
    130                 135                 140                 


Asn Cys Tyr Ser Val Tyr Ala Asp Gln Val Asn Ile Asp Tyr Leu Met 
145                 150                 155                 160 


Asn Arg Pro Gln Asn Leu Arg Leu Glu Met Xaa Ala Ala Lys Asn Xaa 
                165                 170                 175     


Asn Asn Asn Gln Ser Pro Ser Ala Pro Pro Ala Lys Pro Pro Ser Xaa 
            180                 185                 190         


Gln Arg Ala Val Ile Ser Pro Asp Gly Glu Cys Ser Ile Asp Asp Leu 
        195                 200                 205             


Ser Phe Tyr Val Asn Arg Leu Ser Ser Leu Val Ile Gln Met Ala His 
    210                 215                 220                 


Lys Glu Ile Lys Glu Lys Leu Glu Gly Lys Ser Lys Cys Leu His His 
225                 230                 235                 240 


Ser Ile Cys Pro Ser Pro Gly Asn Lys Glu Arg Ile Ser Pro Arg Xaa 
                245                 250                 255     


Pro Ala Ser Lys Ile Ala Ser Glu Met Ala Tyr Glu Ala Val Glu Leu 
            260                 265                 270         


Xaa Ala Ala Glu Met Arg Gly Xaa Gly Glu Glu Ser Arg Glu Gly Gly 
        275                 280                 285             


Gln Lys Ser Phe Leu Tyr Ser Glu Leu Ser Asn Lys Ser Lys Ser Gly 
    290                 295                 300                 


Asp Lys Gln Met Ser Gln Arg Glu Ser Lys Glu Phe Ala Asp Ser Ile 
305                 310                 315                 320 


Ser Lys Gly Leu Met Val Tyr Ala Asn Gln Val Ala Ser Asp Met Met 
                325                 330                 335     


Val Ser Leu Met Lys Xaa Leu Lys Val His Ser Ser Gly Lys Pro Ile 
            340                 345                 350         


Pro Ala Ser Val Val Leu Lys Arg Val Leu Leu Arg His Xaa Lys Glu 
        355                 360                 365             


Ile Val Ser Asp Leu Ile Asp Ser Cys Met Lys Asn Leu His Asn Ile 
    370                 375                 380                 


Xaa Gly Val Leu Met Xaa Asp Ser Asp Phe Val Ser Ala Val Lys Arg 
385                 390                 395                 400 


Asn Leu Phe Asn Gln Trp Lys Gln Asn Ala Xaa Asp Ile Met Glu Ala 
                405                 410                 415     


Met Leu Lys Arg Leu Val Ser Ala Leu Ile Gly Glu Glu Lys Glu Xaa 
            420                 425                 430         


Lys Ser Gln Ser Leu Ser Tyr Ala Ser Leu Lys Ala Gly Ser His Asp 
        435                 440                 445             


Pro Lys Cys Arg Asn Gln Ser Leu Glu Phe Ser Xaa Met Lys Ala Glu 
    450                 455                 460                 


Met Lys Glu Arg Asp Lys Gly Lys Met Lys Ser Asp Pro Cys Lys Ser 
465                 470                 475                 480 


Leu Xaa Ser Ala Glu Lys Val Gly Glu His Ile Leu Lys Glu Gly Leu 
                485                 490                 495     


Xaa Ile Trp Asn Gln Lys Gln Gly Asn Ser Cys Lys Val Ala Xaa Lys 
            500                 505                 510         


Ala Cys Ser Asn Lys Asp Glu Lys Gly Glu Lys Ile Asn Ala Ser Xaa 
        515                 520                 525             


Asp Ser Leu Ala Lys Asp Leu Ile Val Ser Ala Leu Lys Leu Ile Gln 
    530                 535                 540                 


Tyr His Leu Xaa Gln Gln Xaa Lys Gly Lys Asp Xaa Cys Glu Glu Asp 
545                 550                 555                 560 


Cys Pro Gly Ser Xaa Met Gly Tyr Met Ala Gln Ser Xaa Gln Tyr Glu 
                565                 570                 575     


Lys Cys Gly Gly Gly Gln Ser Ala Lys Ala Leu Ser Val Lys Gln Leu 
            580                 585                 590         


Glu Ser His Arg Ala Pro Gly Pro Ser Xaa Cys Gln Lys Glu Asn Gln 
        595                 600                 605             


His Leu Asp Ser Gln Lys Met Asp Met Ser Asn Ile Val Leu Met Leu 
    610                 615                 620                 


Ile Gln Lys Leu Leu Asn Glu Asn Pro Phe Lys Cys Glu Asp Pro Cys 
625                 630                 635                 640 


Glu Gly Glu Asn Lys Cys Ser Glu Pro Arg Ala Ser Lys Ala Ala Ser 
                645                 650                 655     


Met Ser Asn Arg Ser Asp Lys Ala Glu Glu Gln Cys Gln Glu His Gln 
            660                 665                 670         


Glu Leu Asp Cys Xaa Ser Gly Met Lys Gln Ala Asn Gly Gln Phe Ile 
        675                 680                 685             


Asp Lys Leu Val Glu Ser Val Met Lys Leu Cys Leu Ile Met Ala Lys 
    690                 695                 700                 


Tyr Ser Asn Asp Gly Ala Ala Leu Ala Glu Leu Glu Glu Gln Ala Ala 
705                 710                 715                 720 


Ser Ala Asn Lys Pro Asn Phe Arg Gly Xaa Arg Cys Ile His Ser Gly 
                725                 730                 735     


Ala Met Pro Gln Asn Tyr Gln Asp Ser Leu Gly His Glu Val Ile Val 
            740                 745                 750         


Asn Asn Gln Cys Ser Xaa Asn Ser Leu Gln Lys Gln Leu Gln Ala Val 
        755                 760                 765             


Leu Gln Trp Ile Ala Ala Ser Gln Phe Asn Val Pro Met Leu Tyr Phe 
    770                 775                 780                 


Met Gly Asp Lys Asp Gly Gln Leu Glu Lys Leu Pro Gln Val Ser Ala 
785                 790                 795                 800 


Lys Ala Ala Glu Lys Gly Tyr Ser Val Gly Gly Leu Leu Gln Glu Val 
                805                 810                 815     


Met Lys Phe Ala Lys Glu Arg Gln Pro Asp Glu Ala Val Gly Lys Val 
            820                 825                 830         


Ala Arg Lys Gln Leu Leu Asp Trp Leu Leu Ala Asn Leu 
        835                 840                 845 


<210> 2110
<211> 427
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<400> 2110
Met Glu Xaa Xaa Ile Ser Glu Ile His Val Glu Asn Lys Asp Glu Lys 
1               5                   10                  15      


Arg Ser Ala Glu Gly Ser Pro Gly Ala Glu Arg Gln Lys Glu Lys Ala 
            20                  25                  30          


Ser Met Leu Cys Phe Lys Arg Arg Lys Lys Ala Ala Lys Ala Leu Lys 
        35                  40                  45              


Pro Lys Ala Gly Ser Glu Ala Ala Asp Val Ala Arg Lys Cys Pro Gln 
    50                  55                  60                  


Glu Ala Gly Ala Ser Asp Gln Pro Glu Pro Xaa Arg Gly Ala Trp Ala 
65                  70                  75                  80  


Ser Leu Lys Arg Leu Val Xaa Arg Arg Lys Arg Ser Glu Ser Ser Lys 
                85                  90                  95      


Gln Gln Lys Pro Leu Glu Gly Glu Met Gln Pro Ala Ile Asn Ala Glu 
            100                 105                 110         


Asp Ala Asp Leu Ser Lys Lys Lys Ala Lys Ser Arg Leu Lys Ile Pro 
        115                 120                 125             


Cys Ile Lys Phe Pro Arg Gly Pro Lys Arg Ser Asn His Ser Lys Ile 
    130                 135                 140                 


Ile Glu Asp Ser Asp Cys Ser Ile Lys Val Gln Glu Glu Ala Glu Ile 
145                 150                 155                 160 


Leu Asp Ile Gln Xaa Gln Xaa Pro Leu Asn Asp Gln Ala Xaa Lys Ala 
                165                 170                 175     


Lys Ser Xaa Gln Asp Leu Ser Glu Gly Ile Ser Arg Lys Asp Gly Asp 
            180                 185                 190         


Glu Val Cys Glu Ser Asn Val Ser Asn Ser Xaa Xaa Ser Gly Glu Lys 
        195                 200                 205             


Val Ile Ser Val Glu Leu Gly Leu Asp Asn Gly His Ser Ala Ile Gln 
    210                 215                 220                 


Xaa Gly Xaa Leu Ile Leu Glu Glu Ile Glu Xaa Ile Lys Glu Lys Gln 
225                 230                 235                 240 


Asp Val Gln Pro Gln Gln Ala Ser Pro Leu Glu Xaa Ser Glu Xaa Asp 
                245                 250                 255     


His Gln Gln Pro Val Leu Ser Asp Val Pro Pro Leu Pro Ala Ile Pro 
            260                 265                 270         


Asp Gln Gln Ile Val Glu Glu Ala Ser Asn Ser Xaa Leu Glu Ser Ala 
        275                 280                 285             


Pro Asn Gly Lys Asp Tyr Glu Ser Xaa Glu Ile Val Ala Glu Glu Xaa 
    290                 295                 300                 


Lys Pro Lys Asp Xaa Glu Leu Ser Gln Glu Ser Asp Phe Lys Glu Asn 
305                 310                 315                 320 


Gly Ile Xaa Glu Glu Lys Ser Lys Ser Glu Glu Ser Lys Arg Met Glu 
                325                 330                 335     


Pro Ile Ala Ile Ile Ile Xaa Asp Xaa Glu Ile Ser Glu Phe Asp Val 
            340                 345                 350         


Xaa Lys Ser Lys Asn Val Pro Lys Gln Phe Leu Ile Ser Ala Glu Asn 
        355                 360                 365             


Glu Gln Val Gly Val Phe Ala Asn Asp Asn Gly Phe Glu Asp Arg Xaa 
    370                 375                 380                 


Ser Glu Gln Tyr Glu Xaa Leu Leu Ile Glu Xaa Ala Ser Ser Leu Val 
385                 390                 395                 400 


Lys Asn Ala Ile Gln Leu Ser Ile Glu Gln Leu Val Asn Glu Met Ala 
                405                 410                 415     


Ser Asp Asp Asn Lys Ile Asn Asn Leu Leu Gln 
            420                 425         


<210> 2111
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 2111
Met Leu Xaa Met Ser Val Xaa Leu Ser Pro Leu Arg Ser Gln Asp Leu 
1               5                   10                  15      


Asp Pro Met Ala Xaa Asp Ala Ser Pro Met Ala Ile Asn Met Xaa Pro 
            20                  25                  30          


Xaa Val Glu Gln Gly Glu Gly Glu Glu Ala Met Lys Asp Met Asp Ser 
        35                  40                  45              


Asp Gln Gln Tyr Glu Lys Pro Pro Pro Leu His Xaa Gly Ala Asp Trp 
    50                  55                  60                  


Lys Ile Val Leu His Leu Pro Glu Ile Glu Xaa Trp Leu Arg Met Xaa 
65                  70                  75                  80  


Ser Glu Arg Val Arg Asp Leu Xaa Tyr Ser Val Gln Gln Asp Ser Asp 
                85                  90                  95      


Ser Lys His Val Asp Val His Leu Val Gln Leu Lys 
            100                 105             


<210> 2112
<211> 1075
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<400> 2112
Met Leu Xaa Met Ser Val Xaa Leu Ser Pro Leu Arg Ser Gln Asp Leu 
1               5                   10                  15      


Asp Pro Met Ala Xaa Asp Ala Ser Pro Met Ala Ile Asn Met Xaa Pro 
            20                  25                  30          


Xaa Val Glu Gln Gly Glu Gly Glu Glu Ala Met Lys Asp Met Asp Ser 
        35                  40                  45              


Asp Gln Gln Tyr Glu Lys Pro Pro Pro Leu His Xaa Gly Ala Asp Trp 
    50                  55                  60                  


Lys Ile Val Leu His Leu Pro Glu Ile Glu Xaa Trp Leu Arg Met Xaa 
65                  70                  75                  80  


Ser Glu Arg Val Arg Asp Leu Xaa Tyr Ser Val Gln Gln Asp Ser Asp 
                85                  90                  95      


Ser Lys His Val Asp Val His Leu Val Gln Leu Lys Asp Ile Cys Glu 
            100                 105                 110         


Asp Ile Ser Asp His Val Glu Gln Ile His Ala Leu Leu Glu Xaa Glu 
        115                 120                 125             


Phe Ser Leu Lys Leu Leu Ser Tyr Ser Val Asn Val Ile Val Asp Ile 
    130                 135                 140                 


His Ala Val Gln Leu Leu Trp His Gln Leu Arg Val Ser Val Leu Val 
145                 150                 155                 160 


Leu Arg Glu Arg Ile Leu Gln Gly Leu Gln Asp Ala Asn Gly Asn Tyr 
                165                 170                 175     


Xaa Arg Gln Xaa Asp Ile Leu Gln Ala Phe Ser Glu Glu Xaa Lys Glu 
            180                 185                 190         


Gly Arg Leu Asp Ser Leu Xaa Glu Val Asp Asp Ser Gly Gln Leu Xaa 
        195                 200                 205             


Ile Lys Cys Ser Gln Asn Tyr Leu Ser Leu Asp Cys Gly Ile Xaa Ala 
    210                 215                 220                 


Phe Glu Leu Ser Asp Tyr Ser Pro Ser Glu Asp Leu Leu Ser Gly Leu 
225                 230                 235                 240 


Gly Asp Met Xaa Ser Ser Gln Val Lys Xaa Lys Pro Phe Asp Ser Trp 
                245                 250                 255     


Ser Tyr Ser Glu Met Glu Lys Glu Phe Pro Glu Leu Ile Arg Ser Val 
            260                 265                 270         


Gly Leu Leu Xaa Val Ala Ala Asp Ser Ile Ser Xaa Asn Gly Ser Glu 
        275                 280                 285             


Ala Val Xaa Glu Glu Val Ser Gln Val Ser Leu Ser Val Asp Asp Lys 
    290                 295                 300                 


Gly Gly Cys Glu Glu Asp Asn Ala Ser Ala Val Glu Glu Gln Pro Gly 
305                 310                 315                 320 


Leu Xaa Leu Gly Val Ser Ser Ser Ser Gly Glu Ala Leu Xaa Asn Ala 
                325                 330                 335     


Ala Gln Pro Ser Ser Glu Xaa Val Gln Gln Glu Ser Ser Ser Ser Ser 
            340                 345                 350         


His His Asp Ala Lys Asn Gln Gln Pro Val Pro Cys Glu Asn Ala Xaa 
        355                 360                 365             


Pro Lys Arg Xaa Ile Arg Asp Cys Phe Asn Tyr Asn Glu Asp Ser Pro 
    370                 375                 380                 


Xaa Gln Pro Xaa Leu Pro Lys Arg Gly Leu Phe Leu Lys Glu Glu Xaa 
385                 390                 395                 400 


Phe Lys Asn Asp Leu Lys Gly Asn Gly Gly Lys Arg Gln Met Val Asp 
                405                 410                 415     


Leu Lys Pro Glu Met Ser Arg Ser Xaa Pro Ser Leu Val Asp Pro Pro 
            420                 425                 430         


Asp Arg Ser Lys Leu Cys Leu Val Leu Gln Ser Ser Tyr Pro Asn Ser 
        435                 440                 445             


Pro Ser Ala Ala Ser Gln Ser Tyr Glu Cys Leu His Lys Val Gly Asn 
    450                 455                 460                 


Gly Asn Leu Glu Asn Xaa Val Lys Phe His Ile Lys Glu Ile Ser Ser 
465                 470                 475                 480 


Ser Leu Gly Arg Leu Asn Asp Cys Tyr Lys Glu Lys Ser Arg Leu Lys 
                485                 490                 495     


Lys Pro His Lys Xaa Ser Glu Glu Val Pro Pro Cys Arg Xaa Pro Lys 
            500                 505                 510         


Arg Gly Xaa Gly Ser Gly Lys Gln Ala Lys Asn Xaa Lys Ser Ser Ala 
        515                 520                 525             


Val Pro Asn Gly Glu Leu Ser Tyr Xaa Ser Lys Ala Ile Glu Gly Pro 
    530                 535                 540                 


Gln Xaa Asn Ser Ala Ser Xaa Ser Ser Leu Glu Pro Cys Asn Gln Arg 
545                 550                 555                 560 


Ser Trp Asn Ala Lys Leu Gln Leu Gln Ser Glu Xaa Ser Ser Ser Pro 
                565                 570                 575     


Ala Phe Xaa Gln Ser Ser Glu Ser Ser Val Gly Ser Asp Asn Ile Met 
            580                 585                 590         


Ser Pro Val Pro Leu Leu Ser Lys His Lys Ser Lys Lys Gly Gln Ala 
        595                 600                 605             


Ser Ser Pro Ser His Val Xaa Arg Asn Gly Glu Val Val Glu Ala Trp 
    610                 615                 620                 


Tyr Gly Ser Asp Glu Tyr Leu Ala Leu Pro Ser His Leu Lys Gln Xaa 
625                 630                 635                 640 


Glu Val Leu Ala Leu Lys Leu Glu Asn Leu Xaa Lys Leu Leu Pro Gln 
                645                 650                 655     


Lys Pro Arg Gly Glu Xaa Ile Gln Asn Ile Asp Asp Trp Glu Leu Ser 
            660                 665                 670         


Glu Met Asn Ser Asp Ser Glu Ile Tyr Pro Xaa Tyr His Val Lys Lys 
        675                 680                 685             


Lys His Xaa Arg Leu Gly Arg Val Ser Pro Ser Ser Ser Ser Asp Ile 
    690                 695                 700                 


Ala Ser Ser Leu Gly Glu Ser Ile Glu Ser Gly Pro Leu Ser Asp Ile 
705                 710                 715                 720 


Leu Ser Asp Glu Glu Ser Ser Met Pro Leu Ala Gly Met Lys Lys Tyr 
                725                 730                 735     


Ala Asp Glu Lys Ser Glu Arg Ala Ser Ser Ser Glu Lys Asn Glu Ser 
            740                 745                 750         


His Ser Ala Xaa Lys Ser Ala Leu Ile Gln Lys Leu Met Gln Asp Ile 
        755                 760                 765             


Gln His Gln Asp Asn Tyr Glu Ala Ile Trp Glu Lys Ile Glu Gly Phe 
    770                 775                 780                 


Val Asn Lys Leu Asp Glu Phe Ile Gln Trp Leu Asn Glu Ala Met Glu 
785                 790                 795                 800 


Xaa Xaa Glu Asn Trp Xaa Pro Pro Lys Ala Glu Met Asp Asp Leu Lys 
                805                 810                 815     


Leu Tyr Leu Glu Xaa His Leu Ser Phe Lys Leu Asn Val Asp Ser His 
            820                 825                 830         


Cys Ala Leu Lys Glu Ala Val Glu Glu Glu Gly His Gln Leu Leu Glu 
        835                 840                 845             


Leu Ile Ala Ser His Lys Ala Gly Leu Lys Asp Met Leu Arg Met Ile 
    850                 855                 860                 


Ala Ser Gln Trp Lys Glu Leu Gln Arg Gln Ile Lys Arg Gln His Ser 
865                 870                 875                 880 


Trp Ile Leu Arg Ala Leu Asp Xaa Ile Lys Ala Glu Ile Leu Ala Xaa 
                885                 890                 895     


Asp Val Ser Val Glu Asp Glu Glu Gly Xaa Gly Ser Pro Lys Ala Glu 
            900                 905                 910         


Val Gln Leu Cys Tyr Leu Glu Ala Gln Arg Asp Ala Val Glu Gln Met 
        915                 920                 925             


Ser Leu Lys Leu Tyr Ser Glu Gln Tyr Xaa Ser Ser Ser Lys Arg Lys 
    930                 935                 940                 


Glu Glu Phe Ala Asp Met Ser Lys Val His Ser Val Gly Ser Asn Gly 
945                 950                 955                 960 


Leu Leu Asp Phe Asp Ser Glu Tyr Gln Glu Leu Trp Asp Trp Leu Ile 
                965                 970                 975     


Asp Met Glu Ser Leu Val Met Asp Ser His Asp Leu Met Met Ser Glu 
            980                 985                 990         


Glu Gln Gln Gln His Leu Tyr Lys  Arg Tyr Ser Val Glu  Met Ser Ile 
        995                 1000                 1005             


Arg His  Leu Lys Lys Xaa Glu  Leu Leu Ser Lys Val  Glu Ala Leu 
    1010                 1015                 1020             


Lys Lys  Gly Gly Val Leu Leu  Pro Asn Asp Leu Leu  Glu Lys Val 
    1025                 1030                 1035             


Asp Ser  Ile Asn Glu Lys Trp  Glu Leu Leu Gly Val  Phe Ala Phe 
    1040                 1045                 1050             


Leu Leu  Leu Phe Val Gly Tyr  Val Tyr Ile Phe Cys  Val Val Lys 
    1055                 1060                 1065             


Tyr Ser  Val Arg Phe Leu Ile  
    1070                 1075 


<210> 2113
<211> 1245
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1226)..(1226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<400> 2113
Met Leu Xaa Met Ser Val Xaa Leu Ser Pro Leu Arg Ser Gln Asp Leu 
1               5                   10                  15      


Asp Pro Met Ala Xaa Asp Ala Ser Pro Met Ala Ile Asn Met Xaa Pro 
            20                  25                  30          


Xaa Val Glu Gln Gly Glu Gly Glu Glu Ala Met Lys Asp Met Asp Ser 
        35                  40                  45              


Asp Gln Gln Tyr Glu Lys Pro Pro Pro Leu His Xaa Gly Ala Asp Trp 
    50                  55                  60                  


Lys Ile Val Leu His Leu Pro Glu Ile Glu Xaa Trp Leu Arg Met Xaa 
65                  70                  75                  80  


Ser Glu Arg Val Arg Asp Leu Xaa Tyr Ser Val Gln Gln Asp Ser Asp 
                85                  90                  95      


Ser Lys His Val Asp Val His Leu Val Gln Leu Lys Asp Ile Cys Glu 
            100                 105                 110         


Asp Ile Ser Asp His Val Glu Gln Ile His Ala Leu Leu Glu Xaa Glu 
        115                 120                 125             


Phe Ser Leu Lys Leu Leu Ser Tyr Ser Val Asn Val Ile Val Asp Ile 
    130                 135                 140                 


His Ala Val Gln Leu Leu Trp His Gln Leu Arg Val Ser Val Leu Val 
145                 150                 155                 160 


Leu Arg Glu Arg Ile Leu Gln Gly Leu Gln Asp Ala Asn Gly Asn Tyr 
                165                 170                 175     


Xaa Arg Gln Xaa Asp Ile Leu Gln Ala Phe Ser Glu Glu Xaa Lys Glu 
            180                 185                 190         


Gly Arg Leu Asp Ser Leu Xaa Glu Val Asp Asp Ser Gly Gln Leu Xaa 
        195                 200                 205             


Ile Lys Cys Ser Gln Asn Tyr Leu Ser Leu Asp Cys Gly Ile Xaa Ala 
    210                 215                 220                 


Phe Glu Leu Ser Asp Tyr Ser Pro Ser Glu Asp Leu Leu Ser Gly Leu 
225                 230                 235                 240 


Gly Asp Met Xaa Ser Ser Gln Val Lys Xaa Lys Pro Phe Asp Ser Trp 
                245                 250                 255     


Ser Tyr Ser Glu Met Glu Lys Glu Phe Pro Glu Leu Ile Arg Ser Val 
            260                 265                 270         


Gly Leu Leu Xaa Val Ala Ala Asp Ser Ile Ser Xaa Asn Gly Ser Glu 
        275                 280                 285             


Ala Val Xaa Glu Glu Val Ser Gln Val Ser Leu Ser Val Asp Asp Lys 
    290                 295                 300                 


Gly Gly Cys Glu Glu Asp Asn Ala Ser Ala Val Glu Glu Gln Pro Gly 
305                 310                 315                 320 


Leu Xaa Leu Gly Val Ser Ser Ser Ser Gly Glu Ala Leu Xaa Asn Ala 
                325                 330                 335     


Ala Gln Pro Ser Ser Glu Xaa Val Gln Gln Glu Ser Ser Ser Ser Ser 
            340                 345                 350         


His His Asp Ala Lys Asn Gln Gln Pro Val Pro Cys Glu Asn Ala Xaa 
        355                 360                 365             


Pro Lys Arg Xaa Ile Arg Asp Cys Phe Asn Tyr Asn Glu Asp Ser Pro 
    370                 375                 380                 


Xaa Gln Pro Xaa Leu Pro Lys Arg Gly Leu Phe Leu Lys Glu Glu Xaa 
385                 390                 395                 400 


Phe Lys Asn Asp Leu Lys Gly Asn Gly Gly Lys Arg Gln Met Val Asp 
                405                 410                 415     


Leu Lys Pro Glu Met Ser Arg Ser Xaa Pro Ser Leu Val Asp Pro Pro 
            420                 425                 430         


Asp Arg Ser Lys Leu Cys Leu Val Leu Gln Ser Ser Tyr Pro Asn Ser 
        435                 440                 445             


Pro Ser Ala Ala Ser Gln Ser Tyr Glu Cys Leu His Lys Val Gly Asn 
    450                 455                 460                 


Gly Asn Leu Glu Asn Xaa Val Lys Phe His Ile Lys Glu Ile Ser Ser 
465                 470                 475                 480 


Ser Leu Gly Arg Leu Asn Asp Cys Tyr Lys Glu Lys Ser Arg Leu Lys 
                485                 490                 495     


Lys Pro His Lys Xaa Ser Glu Glu Val Pro Pro Cys Arg Xaa Pro Lys 
            500                 505                 510         


Arg Gly Xaa Gly Ser Gly Lys Gln Ala Lys Asn Xaa Lys Ser Ser Ala 
        515                 520                 525             


Val Pro Asn Gly Glu Leu Ser Tyr Xaa Ser Lys Ala Ile Glu Gly Pro 
    530                 535                 540                 


Gln Xaa Asn Ser Ala Ser Xaa Ser Ser Leu Glu Pro Cys Asn Gln Arg 
545                 550                 555                 560 


Ser Trp Asn Ala Lys Leu Gln Leu Gln Ser Glu Xaa Ser Ser Ser Pro 
                565                 570                 575     


Ala Phe Xaa Gln Ser Ser Glu Ser Ser Val Gly Ser Asp Asn Ile Met 
            580                 585                 590         


Ser Pro Val Pro Leu Leu Ser Lys His Lys Ser Lys Lys Gly Gln Ala 
        595                 600                 605             


Ser Ser Pro Ser His Val Xaa Arg Asn Gly Glu Val Val Glu Ala Trp 
    610                 615                 620                 


Tyr Gly Ser Asp Glu Tyr Leu Ala Leu Pro Ser His Leu Lys Gln Xaa 
625                 630                 635                 640 


Glu Val Leu Ala Leu Lys Leu Glu Asn Leu Xaa Lys Leu Leu Pro Gln 
                645                 650                 655     


Lys Pro Arg Gly Glu Xaa Ile Gln Asn Ile Asp Asp Trp Glu Leu Ser 
            660                 665                 670         


Glu Met Asn Ser Asp Ser Glu Ile Tyr Pro Xaa Tyr His Val Lys Lys 
        675                 680                 685             


Lys His Xaa Arg Leu Gly Arg Val Ser Pro Ser Ser Ser Ser Asp Ile 
    690                 695                 700                 


Ala Ser Ser Leu Gly Glu Ser Ile Glu Ser Gly Pro Leu Ser Asp Ile 
705                 710                 715                 720 


Leu Ser Asp Glu Glu Ser Ser Met Pro Leu Ala Gly Met Lys Lys Tyr 
                725                 730                 735     


Ala Asp Glu Lys Ser Glu Arg Ala Ser Ser Ser Glu Lys Asn Glu Ser 
            740                 745                 750         


His Ser Ala Xaa Lys Ser Ala Leu Ile Gln Lys Leu Met Gln Asp Ile 
        755                 760                 765             


Gln His Gln Asp Asn Tyr Glu Ala Ile Trp Glu Lys Ile Glu Gly Phe 
    770                 775                 780                 


Val Asn Lys Leu Asp Glu Phe Ile Gln Trp Leu Asn Glu Ala Met Glu 
785                 790                 795                 800 


Xaa Xaa Glu Asn Trp Xaa Pro Pro Lys Ala Glu Met Asp Asp Leu Lys 
                805                 810                 815     


Leu Tyr Leu Glu Xaa His Leu Ser Phe Lys Leu Asn Val Asp Ser His 
            820                 825                 830         


Cys Ala Leu Lys Glu Ala Val Glu Glu Glu Gly His Gln Leu Leu Glu 
        835                 840                 845             


Leu Ile Ala Ser His Lys Ala Gly Leu Lys Asp Met Leu Arg Met Ile 
    850                 855                 860                 


Ala Ser Gln Trp Lys Glu Leu Gln Arg Gln Ile Lys Arg Gln His Ser 
865                 870                 875                 880 


Trp Ile Leu Arg Ala Leu Asp Xaa Ile Lys Ala Glu Ile Leu Ala Xaa 
                885                 890                 895     


Asp Val Ser Val Glu Asp Glu Glu Gly Xaa Gly Ser Pro Lys Ala Glu 
            900                 905                 910         


Val Gln Leu Cys Tyr Leu Glu Ala Gln Arg Asp Ala Val Glu Gln Met 
        915                 920                 925             


Ser Leu Lys Leu Tyr Ser Glu Gln Tyr Xaa Ser Ser Ser Lys Arg Lys 
    930                 935                 940                 


Glu Glu Phe Ala Asp Met Ser Lys Val His Ser Val Gly Ser Asn Gly 
945                 950                 955                 960 


Leu Leu Asp Phe Asp Ser Glu Tyr Gln Glu Leu Trp Asp Trp Leu Ile 
                965                 970                 975     


Asp Met Glu Ser Leu Val Met Asp Ser His Asp Leu Met Met Ser Glu 
            980                 985                 990         


Glu Gln Gln Gln His Leu Tyr Lys  Arg Tyr Ser Val Glu  Met Ser Ile 
        995                 1000                 1005             


Arg His  Leu Lys Lys Xaa Glu  Leu Leu Ser Lys Val  Glu Ala Leu 
    1010                 1015                 1020             


Lys Lys  Gly Gly Val Leu Leu  Pro Asn Asp Leu Leu  Glu Lys Val 
    1025                 1030                 1035             


Asp Ser  Ile Asn Glu Lys Trp  Glu Leu Leu Gly Lys  Xaa Leu Gly 
    1040                 1045                 1050             


Glu Lys  Ile Gln Asp Xaa Met  Ala Gly His Ser Gly  Ser Ser Pro 
    1055                 1060                 1065             


Arg Asp  Leu Leu Ser Pro Glu  Ser Gly Ser Leu Val  Arg Gln Leu 
    1070                 1075                 1080             


Glu Val  Arg Ile Lys Glu Leu  Lys Gly Trp Leu Arg  Asp Xaa Glu 
    1085                 1090                 1095             


Leu Phe  Ile Phe Asn Ser Cys  Leu Arg Gln Glu Lys  Glu Gly Xaa 
    1100                 1105                 1110             


Met Asn  Xaa Glu Lys Gln Leu  Gln Tyr Phe Lys Ser  Leu Cys Arg 
    1115                 1120                 1125             


Glu Ile  Lys Gln Arg Arg Arg  Gly Val Ala Ser Ile  Leu Arg Leu 
    1130                 1135                 1140             


Cys Gln  His Leu Leu Asp Asp  Arg Glu Xaa Cys Asn  Leu Asn Ala 
    1145                 1150                 1155             


Asp His  Gln Pro Met Gln Leu  Ile Ile Val Asn Leu  Glu Arg Arg 
    1160                 1165                 1170             


Trp Glu  Ala Ile Val Met Gln  Ala Val Gln Trp Gln  Xaa Arg Leu 
    1175                 1180                 1185             


Gln Lys  Lys Met Gly Lys Glu  Ser Ile Arg Leu Ala  Ala Xaa Gln 
    1190                 1195                 1200             


Gly Trp  Pro His Pro Pro Ala  Leu Gly Trp Pro Leu  Val Pro Ser 
    1205                 1210                 1215             


Arg Leu  Ser Leu Pro Phe Ile  Xaa Leu Xaa Ser Pro  Lys Met Asn 
    1220                 1225                 1230             


Leu Pro  Ser Lys Cys Val Phe  Ser Xaa Gln Ala Leu  
    1235                 1240                 1245 


<210> 2114
<211> 2319
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1278)..(1278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1315)..(1315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1321)..(1321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1372)..(1372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1374)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1395)..(1395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1447)..(1447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1466)..(1466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1515)..(1516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1549)..(1549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1551)..(1551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1601)..(1601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1632)..(1632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1658)..(1658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1669)..(1669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1689)..(1689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1723)..(1723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1743)..(1743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1747)..(1747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1762)..(1762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1764)..(1764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1781)..(1781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1804)..(1804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1813)..(1813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1837)..(1837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1842)..(1842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1847)..(1847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1869)..(1869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1874)..(1874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1881)..(1881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1913)..(1913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1947)..(1947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1975)..(1975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1978)..(1978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1980)..(1980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1991)..(1991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2027)..(2027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2069)..(2069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2085)..(2085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2088)..(2088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2126)..(2126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2135)..(2135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2141)..(2142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2192)..(2192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2210)..(2210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2234)..(2234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2245)..(2245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2288)..(2288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2299)..(2299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2301)..(2301)
<223> Selenocysteine

<400> 2114
Met Leu Xaa Met Ser Val Xaa Leu Ser Pro Leu Arg Ser Gln Asp Leu 
1               5                   10                  15      


Asp Pro Met Ala Xaa Asp Ala Ser Pro Met Ala Ile Asn Met Xaa Pro 
            20                  25                  30          


Xaa Val Glu Gln Gly Glu Gly Glu Glu Ala Met Lys Asp Met Asp Ser 
        35                  40                  45              


Asp Gln Gln Tyr Glu Lys Pro Pro Pro Leu His Xaa Gly Ala Asp Trp 
    50                  55                  60                  


Lys Ile Val Leu His Leu Pro Glu Ile Glu Xaa Trp Leu Arg Met Xaa 
65                  70                  75                  80  


Ser Glu Arg Val Arg Asp Leu Xaa Tyr Ser Val Gln Gln Asp Ser Asp 
                85                  90                  95      


Ser Lys His Val Asp Val His Leu Val Gln Leu Lys Asp Ile Cys Glu 
            100                 105                 110         


Asp Ile Ser Asp His Val Glu Gln Ile His Ala Leu Leu Glu Xaa Glu 
        115                 120                 125             


Phe Ser Leu Lys Leu Leu Ser Tyr Ser Val Asn Val Ile Val Asp Ile 
    130                 135                 140                 


His Ala Val Gln Leu Leu Trp His Gln Leu Arg Val Ser Val Leu Val 
145                 150                 155                 160 


Leu Arg Glu Arg Ile Leu Gln Gly Leu Gln Asp Ala Asn Gly Asn Tyr 
                165                 170                 175     


Xaa Arg Gln Xaa Asp Ile Leu Gln Ala Phe Ser Glu Glu Xaa Lys Glu 
            180                 185                 190         


Gly Arg Leu Asp Ser Leu Xaa Glu Val Asp Asp Ser Gly Gln Leu Xaa 
        195                 200                 205             


Ile Lys Cys Ser Gln Asn Tyr Leu Ser Leu Asp Cys Gly Ile Xaa Ala 
    210                 215                 220                 


Phe Glu Leu Ser Asp Tyr Ser Pro Ser Glu Asp Leu Leu Ser Gly Leu 
225                 230                 235                 240 


Gly Asp Met Xaa Ser Ser Gln Val Lys Xaa Lys Pro Phe Asp Ser Trp 
                245                 250                 255     


Ser Tyr Ser Glu Met Glu Lys Glu Phe Pro Glu Leu Ile Arg Ser Val 
            260                 265                 270         


Gly Leu Leu Xaa Val Ala Ala Asp Ser Ile Ser Xaa Asn Gly Ser Glu 
        275                 280                 285             


Ala Val Xaa Glu Glu Val Ser Gln Val Ser Leu Ser Val Asp Asp Lys 
    290                 295                 300                 


Gly Gly Cys Glu Glu Asp Asn Ala Ser Ala Val Glu Glu Gln Pro Gly 
305                 310                 315                 320 


Leu Xaa Leu Gly Val Ser Ser Ser Ser Gly Glu Ala Leu Xaa Asn Ala 
                325                 330                 335     


Ala Gln Pro Ser Ser Glu Xaa Val Gln Gln Glu Ser Ser Ser Ser Ser 
            340                 345                 350         


His His Asp Ala Lys Asn Gln Gln Pro Val Pro Cys Glu Asn Ala Xaa 
        355                 360                 365             


Pro Lys Arg Xaa Ile Arg Asp Cys Phe Asn Tyr Asn Glu Asp Ser Pro 
    370                 375                 380                 


Xaa Gln Pro Xaa Leu Pro Lys Arg Gly Leu Phe Leu Lys Glu Glu Xaa 
385                 390                 395                 400 


Phe Lys Asn Asp Leu Lys Gly Asn Gly Gly Lys Arg Gln Met Val Asp 
                405                 410                 415     


Leu Lys Pro Glu Met Ser Arg Ser Xaa Pro Ser Leu Val Asp Pro Pro 
            420                 425                 430         


Asp Arg Ser Lys Leu Cys Leu Val Leu Gln Ser Ser Tyr Pro Asn Ser 
        435                 440                 445             


Pro Ser Ala Ala Ser Gln Ser Tyr Glu Cys Leu His Lys Val Gly Asn 
    450                 455                 460                 


Gly Asn Leu Glu Asn Xaa Val Lys Phe His Ile Lys Glu Ile Ser Ser 
465                 470                 475                 480 


Ser Leu Gly Arg Leu Asn Asp Cys Tyr Lys Glu Lys Ser Arg Leu Lys 
                485                 490                 495     


Lys Pro His Lys Xaa Ser Glu Glu Val Pro Pro Cys Arg Xaa Pro Lys 
            500                 505                 510         


Arg Gly Xaa Gly Ser Gly Lys Gln Ala Lys Asn Xaa Lys Ser Ser Ala 
        515                 520                 525             


Val Pro Asn Gly Glu Leu Ser Tyr Xaa Ser Lys Ala Ile Glu Gly Pro 
    530                 535                 540                 


Gln Xaa Asn Ser Ala Ser Xaa Ser Ser Leu Glu Pro Cys Asn Gln Arg 
545                 550                 555                 560 


Ser Trp Asn Ala Lys Leu Gln Leu Gln Ser Glu Xaa Ser Ser Ser Pro 
                565                 570                 575     


Ala Phe Xaa Gln Ser Ser Glu Ser Ser Val Gly Ser Asp Asn Ile Met 
            580                 585                 590         


Ser Pro Val Pro Leu Leu Ser Lys His Lys Ser Lys Lys Gly Gln Ala 
        595                 600                 605             


Ser Ser Pro Ser His Val Xaa Arg Asn Gly Glu Val Val Glu Ala Trp 
    610                 615                 620                 


Tyr Gly Ser Asp Glu Tyr Leu Ala Leu Pro Ser His Leu Lys Gln Xaa 
625                 630                 635                 640 


Glu Val Leu Ala Leu Lys Leu Glu Asn Leu Xaa Lys Leu Leu Pro Gln 
                645                 650                 655     


Lys Pro Arg Gly Glu Xaa Ile Gln Asn Ile Asp Asp Trp Glu Leu Ser 
            660                 665                 670         


Glu Met Asn Ser Asp Ser Glu Ile Tyr Pro Xaa Tyr His Val Lys Lys 
        675                 680                 685             


Lys His Xaa Arg Leu Gly Arg Val Ser Pro Ser Ser Ser Ser Asp Ile 
    690                 695                 700                 


Ala Ser Ser Leu Gly Glu Ser Ile Glu Ser Gly Pro Leu Ser Asp Ile 
705                 710                 715                 720 


Leu Ser Asp Glu Glu Ser Ser Met Pro Leu Ala Gly Met Lys Lys Tyr 
                725                 730                 735     


Ala Asp Glu Lys Ser Glu Arg Ala Ser Ser Ser Glu Lys Asn Glu Ser 
            740                 745                 750         


His Ser Ala Xaa Lys Ser Ala Leu Ile Gln Lys Leu Met Gln Asp Ile 
        755                 760                 765             


Gln His Gln Asp Asn Tyr Glu Ala Ile Trp Glu Lys Ile Glu Gly Phe 
    770                 775                 780                 


Val Asn Lys Leu Asp Glu Phe Ile Gln Trp Leu Asn Glu Ala Met Glu 
785                 790                 795                 800 


Xaa Xaa Glu Asn Trp Xaa Pro Pro Lys Ala Glu Met Asp Asp Leu Lys 
                805                 810                 815     


Leu Tyr Leu Glu Xaa His Leu Ser Phe Lys Leu Asn Val Asp Ser His 
            820                 825                 830         


Cys Ala Leu Lys Glu Ala Val Glu Glu Glu Gly His Gln Leu Leu Glu 
        835                 840                 845             


Leu Ile Ala Ser His Lys Ala Gly Leu Lys Asp Met Leu Arg Met Ile 
    850                 855                 860                 


Ala Ser Gln Trp Lys Glu Leu Gln Arg Gln Ile Lys Arg Gln His Ser 
865                 870                 875                 880 


Trp Ile Leu Arg Ala Leu Asp Xaa Ile Lys Ala Glu Ile Leu Ala Xaa 
                885                 890                 895     


Asp Val Ser Val Glu Asp Glu Glu Gly Xaa Gly Ser Pro Lys Ala Glu 
            900                 905                 910         


Val Gln Leu Cys Tyr Leu Glu Ala Gln Arg Asp Ala Val Glu Gln Met 
        915                 920                 925             


Ser Leu Lys Leu Tyr Ser Glu Gln Tyr Xaa Ser Ser Ser Lys Arg Lys 
    930                 935                 940                 


Glu Glu Phe Ala Asp Met Ser Lys Val His Ser Val Gly Ser Asn Gly 
945                 950                 955                 960 


Leu Leu Asp Phe Asp Ser Glu Tyr Gln Glu Leu Trp Asp Trp Leu Ile 
                965                 970                 975     


Asp Met Glu Ser Leu Val Met Asp Ser His Asp Leu Met Met Ser Glu 
            980                 985                 990         


Glu Gln Gln Gln His Leu Tyr Lys  Arg Tyr Ser Val Glu  Met Ser Ile 
        995                 1000                 1005             


Arg His  Leu Lys Lys Xaa Glu  Leu Leu Ser Lys Val  Glu Ala Leu 
    1010                 1015                 1020             


Lys Lys  Gly Gly Val Leu Leu  Pro Asn Asp Leu Leu  Glu Lys Val 
    1025                 1030                 1035             


Asp Ser  Ile Asn Glu Lys Trp  Glu Leu Leu Gly Lys  Xaa Leu Gly 
    1040                 1045                 1050             


Glu Lys  Ile Gln Asp Xaa Met  Ala Gly His Ser Gly  Ser Ser Pro 
    1055                 1060                 1065             


Arg Asp  Leu Leu Ser Pro Glu  Ser Gly Ser Leu Val  Arg Gln Leu 
    1070                 1075                 1080             


Glu Val  Arg Ile Lys Glu Leu  Lys Gly Trp Leu Arg  Asp Xaa Glu 
    1085                 1090                 1095             


Leu Phe  Ile Phe Asn Ser Cys  Leu Arg Gln Glu Lys  Glu Gly Xaa 
    1100                 1105                 1110             


Met Asn  Xaa Glu Lys Gln Leu  Gln Tyr Phe Lys Ser  Leu Cys Arg 
    1115                 1120                 1125             


Glu Ile  Lys Gln Arg Arg Arg  Gly Val Ala Ser Ile  Leu Arg Leu 
    1130                 1135                 1140             


Cys Gln  His Leu Leu Asp Asp  Arg Glu Xaa Cys Asn  Leu Asn Ala 
    1145                 1150                 1155             


Asp His  Gln Pro Met Gln Leu  Ile Ile Val Asn Leu  Glu Arg Arg 
    1160                 1165                 1170             


Trp Glu  Ala Ile Val Met Gln  Ala Val Gln Trp Gln  Xaa Arg Leu 
    1175                 1180                 1185             


Gln Lys  Lys Met Gly Lys Glu  Ser Glu Xaa Leu Asn  Val Ile Asp 
    1190                 1195                 1200             


Pro Gly  Leu Met Asp Leu Asn  Gly Met Ser Glu Asp  Ala Leu Glu 
    1205                 1210                 1215             


Trp Asp  Glu Met Asp Ile Ser  Asn Lys Leu Ile Ser  Leu Asn Glu 
    1220                 1225                 1230             


Glu Ser  Asn Asp Leu Asp Gln  Glu Leu Gln Pro Val  Ile Pro Ser 
    1235                 1240                 1245             


Leu Lys  Leu Gly Glu Xaa Ser  Asn Glu Asp Pro Gly  Tyr Asp Glu 
    1250                 1255                 1260             


Glu Ala  Asp Asn His Gly Gly  Ser Gln Tyr Ala Ser  Asn Ile Xaa 
    1265                 1270                 1275             


Ala Pro  Ser Ser Pro His Ile  Tyr Gln Val Tyr Ser  Leu His Asn 
    1280                 1285                 1290             


Val Glu  Leu Tyr Glu Asp Asn  His Met Pro Phe Leu  Lys Asn Asn 
    1295                 1300                 1305             


Pro Lys  Val Xaa Gly Met Xaa  Gln Pro Asn Val Leu  Xaa Lys Ser 
    1310                 1315                 1320             


Leu Ser  Lys Asp Ser Ser Phe  Ser Ser Xaa Lys Ser  Leu Pro Asp 
    1325                 1330                 1335             


Leu Leu  Gly Gly Ser Asn Leu  Val Lys Pro Cys Ala  Cys His Gly 
    1340                 1345                 1350             


Gly Asp  Met Ser Gln Asn Ser  Gly Ser Glu Ser Gly  Ile Val Ser 
    1355                 1360                 1365             


Glu Gly  Asp Xaa Glu Xaa Xaa  Xaa Asn Ser Glu Met  Cys Leu Leu 
    1370                 1375                 1380             


Asn Ala  Val Asp Gly Ser Pro  Ser Asn Leu Glu Xaa  Glu His Leu 
    1385                 1390                 1395             


Asp Pro  Gln Met Gly Asp Ala  Val Asn Val Leu Lys  Gln Lys Phe 
    1400                 1405                 1410             


Xaa Asp  Glu Gly Glu Ser Ile  Lys Leu Pro Asn Ser  Ser Gln Ser 
    1415                 1420                 1425             


Ser Ile  Ser Pro Val Gly Cys  Val Asn Gly Lys Val  Gly Asp Leu 
    1430                 1435                 1440             


Asn Ser  Ile Xaa Lys His Xaa  Pro Asp Cys Leu Gly  Glu Glu Leu 
    1445                 1450                 1455             


Gln Gly  Lys His Asp Val Phe  Xaa Phe Tyr Asp Tyr  Ser Tyr Leu 
    1460                 1465                 1470             


Gln Gly  Ser Lys Leu Lys Leu  Pro Met Ile Met Lys  Gln Ser Gln 
    1475                 1480                 1485             


Ser Glu  Lys Ala His Val Glu  Asp Pro Leu Leu Arg  Gly Phe Tyr 
    1490                 1495                 1500             


Phe Asp  Lys Lys Ser Cys Lys  Ser Lys His Gln Xaa  Xaa Glu Leu 
    1505                 1510                 1515             


Gln Pro  Asp Val Pro Pro His  Glu Arg Ile Leu Ala  Ser Ala Ser 
    1520                 1525                 1530             


His Glu  Met Asp Arg Ile Ser  Tyr Lys Ser Gly Asn  Ile Glu Lys 
    1535                 1540                 1545             


Xaa Phe  Xaa Gly Met Gln Asn  Ala Lys Gln Leu Ser  Leu Leu Ser 
    1550                 1555                 1560             


His Ser  Ser Ser Ile Glu Ser  Leu Ser Pro Gly Gly  Asp Leu Phe 
    1565                 1570                 1575             


Gly Leu  Gly Ile Phe Lys Asn  Gly Ser Asp Ser Leu  Gln Arg Ser 
    1580                 1585                 1590             


Xaa Ser  Leu Glu Ser Trp Leu  Xaa Ser Tyr Lys Ser  Asn Glu Asp 
    1595                 1600                 1605             


Leu Phe  Ser Cys His Ser Ser  Gly Asp Ile Ser Val  Ser Ser Gly 
    1610                 1615                 1620             


Ser Val  Gly Glu Leu Ser Lys  Arg Xaa Leu Asp Leu  Leu Asn Arg 
    1625                 1630                 1635             


Leu Glu  Asn Ile Gln Ser Pro  Ser Glu Gln Lys Ile  Lys Arg Ser 
    1640                 1645                 1650             


Val Ser  Asp Ile Xaa Leu Gln  Ser Ser Ser Gln Lys  Met Ser Phe 
    1655                 1660                 1665             


Xaa Gly  Gln Met Ser Leu Asp  Ile Ala Ser Ser Ile  Asn Glu Asp 
    1670                 1675                 1680             


Ser Ala  Ala Ser Leu Xaa Glu  Leu Ser Ser Ser Asp  Glu Leu Ser 
    1685                 1690                 1695             


Leu Cys  Ser Glu Asp Ile Val  Leu His Lys Asn Lys  Ile Pro Glu 
    1700                 1705                 1710             


Ser Asn  Ala Ser Phe Arg Lys  Arg Leu Xaa Arg Ser  Val Ala Asp 
    1715                 1720                 1725             


Glu Ser  Asp Val Asn Val Ser  Met Ile Val Asn Val  Ser Cys Xaa 
    1730                 1735                 1740             


Ser Ala  Cys Xaa Asp Asp Glu  Asp Asp Ser Asp Leu  Leu Ser Ser 
    1745                 1750                 1755             


Ser Xaa  Leu Xaa Leu Xaa Glu  Glu Glu Leu Cys Ile  Lys Asp Glu 
    1760                 1765                 1770             


Asp Asp  Asp Ser Ser Ile Ala  Xaa Asp Asp Glu Ile  Tyr Glu Asp 
    1775                 1780                 1785             


Cys Xaa  Leu Met Ser Gly Leu  Asp Tyr Ile Lys Asn  Glu Leu Gln 
    1790                 1795                 1800             


Xaa Trp  Ile Arg Pro Lys Leu  Ser Leu Xaa Arg Asp  Lys Lys Arg 
    1805                 1810                 1815             


Cys Asn  Val Ser Asp Glu Met  Lys Gly Ser Lys Asp  Ile Ser Ser 
    1820                 1825                 1830             


Ser Glu  Met Xaa Asn Pro Ser  Asp Xaa Leu Asn Ile  Glu Xaa Leu 
    1835                 1840                 1845             


Leu Asn  Gly Ser Val Lys Arg  Val Ser Glu Asn Asn  Gly Asn Gly 
    1850                 1855                 1860             


Lys Asn  Ser Ser His Xaa His  Glu Leu Gly Xaa Lys  Arg Glu Asn 
    1865                 1870                 1875             


Lys Lys  Xaa Ile Phe Lys Val  Asn Lys Asp Pro Tyr  Val Ala Asp 
    1880                 1885                 1890             


Met Glu  Asn Gly Asn Ile Glu  Gly Ile Pro Glu Arg  Gln Lys Gly 
    1895                 1900                 1905             


Lys Pro  Asn Val Xaa Ser Lys  Val Ser Glu Asn Leu  Gly Ser His 
    1910                 1915                 1920             


Gly Lys  Glu Ile Ser Glu Ser  Glu His Cys Lys Cys  Lys Ala Leu 
    1925                 1930                 1935             


Met Asp  Ser Leu Asp Asp Ser  Asn Xaa Ala Gly Lys  Glu Phe Val 
    1940                 1945                 1950             


Ser Gln  Asp Val Arg His Leu  Pro Lys Lys Cys Pro  Asn His His 
    1955                 1960                 1965             


His Phe  Glu Asn Gln Ser Xaa  Ala Ser Xaa Pro Xaa  Glu Lys Ser 
    1970                 1975                 1980             


Phe Ser  Glu Leu Ala Leu Glu  Xaa Arg Phe Asn Asn  Arg Gln Asp 
    1985                 1990                 1995             


Ser Asp  Ala Leu Lys Ser Ser  Asp Asp Ala Pro Ser  Met Ala Gly 
    2000                 2005                 2010             


Lys Ser  Ala Gly Cys Cys Leu  Ala Leu Glu Gln Asn  Gly Xaa Glu 
    2015                 2020                 2025             


Glu Asn  Ala Ser Ile Ser Asn  Ile Ser Cys Cys Asn  Cys Glu Pro 
    2030                 2035                 2040             


Asp Val  Phe His Gln Lys Asp  Ala Glu Asp Cys Ser  Val His Asn 
    2045                 2050                 2055             


Phe Val  Lys Glu Ile Ile Asp  Met Ala Ser Xaa Ala  Leu Lys Ser 
    2060                 2065                 2070             


Lys Ser  Gln Pro Glu Asn Glu  Val Ala Ala Pro Xaa  Ser Leu Xaa 
    2075                 2080                 2085             


Gln Ile  Lys Glu Lys Val Leu  Glu His Ser His Arg  Pro Ile Gln 
    2090                 2095                 2100             


Leu Arg  Lys Gly Asp Phe Tyr  Ser Tyr Leu Ser Leu  Ser Ser His 
    2105                 2110                 2115             


Asp Ser  Asp Cys Gly Glu Val  Xaa Asn Tyr Ile Glu  Glu Lys Ser 
    2120                 2125                 2130             


Ser Xaa  Pro Leu Pro Leu Asp  Xaa Xaa Asp Ser Gly  Leu Asp Asp 
    2135                 2140                 2145             


Lys Glu  Asp Ile Glu Cys Phe  Phe Glu Ala Cys Val  Glu Gly Asp 
    2150                 2155                 2160             


Ser Asp  Gly Glu Glu Pro Cys  Phe Ser Ser Ala Pro  Pro Asn Glu 
    2165                 2170                 2175             


Ser Ala  Val Pro Ser Glu Ala  Ala Met Pro Leu Gln  Ala Xaa Ala 
    2180                 2185                 2190             


Cys Ser  Ser Glu Phe Ser Asp  Ser Ser Leu Ser Ala  Asp Asp Ala 
    2195                 2200                 2205             


Asp Xaa  Val Ala Leu Ser Ser  Pro Ser Ser Gln Glu  Arg Ala Glu 
    2210                 2215                 2220             


Val Gly  Lys Glu Val Asn Gly  Leu Pro Gln Xaa Ser  Ser Gly Cys 
    2225                 2230                 2235             


Ala Glu  Asn Leu Glu Phe Xaa  Pro Ser Lys Leu Asp  Ser Glu Lys 
    2240                 2245                 2250             


Glu Ser  Ser Gly Lys Pro Gly  Glu Ser Gly Met Pro  Glu Glu His 
    2255                 2260                 2265             


Asn Ala  Ala Ser Ala Lys Ser  Lys Val Gln Asp Leu  Ser Leu Lys 
    2270                 2275                 2280             


Ala Asn  Gln Pro Xaa Asp Lys  Ala Ala Leu His Pro  Ser Pro Lys 
    2285                 2290                 2295             


Xaa Leu  Xaa Cys Glu Glu Asn  Leu Leu Asn Leu His  Glu Lys Arg 
    2300                 2305                 2310             


His Arg  Asn Met His Arg 
    2315                 


<210> 2115
<211> 25
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<400> 2115
Met Xaa Ser Ser Gln Val Lys Xaa Lys Pro Phe Asp Ser Trp Ser Tyr 
1               5                   10                  15      


Ser Glu Met Glu Lys Glu Phe Pro Glu 
            20                  25  


<210> 2116
<211> 47
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<400> 2116
Met Xaa Ser Ser Gln Val Lys Xaa Lys Pro Phe Asp Ser Trp Ser Tyr 
1               5                   10                  15      


Ser Glu Met Glu Lys Glu Phe Pro Glu Leu Ile Arg Ser Val Gly Leu 
            20                  25                  30          


Leu Xaa Val Ala Ala Asp Ser Ile Ser Xaa Asn Gly Ser Glu Ala 
        35                  40                  45          


<210> 2117
<211> 357
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<400> 2117
Met Xaa Ser Ser Gln Val Lys Xaa Lys Pro Phe Asp Ser Trp Ser Tyr 
1               5                   10                  15      


Ser Glu Met Glu Lys Glu Phe Pro Glu Leu Ile Arg Ser Val Gly Leu 
            20                  25                  30          


Leu Xaa Val Ala Ala Asp Ser Ile Ser Xaa Asn Gly Ser Glu Ala Val 
        35                  40                  45              


Xaa Glu Glu Val Ser Gln Val Ser Leu Ser Val Asp Asp Lys Gly Gly 
    50                  55                  60                  


Cys Glu Glu Asp Asn Ala Ser Ala Val Glu Glu Gln Pro Gly Leu Xaa 
65                  70                  75                  80  


Leu Gly Val Ser Ser Ser Ser Gly Glu Ala Leu Xaa Asn Ala Ala Gln 
                85                  90                  95      


Pro Ser Ser Glu Xaa Val Gln Gln Glu Ser Ser Ser Ser Ser His His 
            100                 105                 110         


Asp Ala Lys Asn Gln Gln Pro Val Pro Cys Glu Asn Ala Xaa Pro Lys 
        115                 120                 125             


Arg Xaa Ile Arg Asp Cys Phe Asn Tyr Asn Glu Asp Ser Pro Xaa Gln 
    130                 135                 140                 


Pro Xaa Leu Pro Lys Arg Gly Leu Phe Leu Lys Glu Glu Xaa Phe Lys 
145                 150                 155                 160 


Asn Asp Leu Lys Gly Asn Gly Gly Lys Arg Gln Met Val Asp Leu Lys 
                165                 170                 175     


Pro Glu Met Ser Arg Ser Xaa Pro Ser Leu Val Asp Pro Pro Asp Arg 
            180                 185                 190         


Ser Lys Leu Cys Leu Val Leu Gln Ser Ser Tyr Pro Asn Ser Pro Ser 
        195                 200                 205             


Ala Ala Ser Gln Ser Tyr Glu Cys Leu His Lys Val Gly Asn Gly Asn 
    210                 215                 220                 


Leu Glu Asn Xaa Val Lys Phe His Ile Lys Glu Ile Ser Ser Ser Leu 
225                 230                 235                 240 


Gly Arg Leu Asn Asp Cys Tyr Lys Glu Lys Ser Arg Leu Lys Lys Pro 
                245                 250                 255     


His Lys Xaa Ser Glu Glu Val Pro Pro Cys Arg Xaa Pro Lys Arg Gly 
            260                 265                 270         


Xaa Gly Ser Gly Lys Gln Ala Lys Asn Xaa Lys Ser Ser Ala Val Pro 
        275                 280                 285             


Asn Gly Glu Leu Ser Tyr Xaa Ser Lys Ala Ile Glu Gly Pro Gln Xaa 
    290                 295                 300                 


Asn Ser Ala Ser Xaa Ser Ser Leu Glu Pro Cys Asn Gln Arg Ser Trp 
305                 310                 315                 320 


Asn Ala Lys Leu Gln Leu Gln Ser Glu Xaa Ser Ser Ser Pro Ala Phe 
                325                 330                 335     


Xaa Gln Ser Ser Glu Ser Ser Val Gly Ser Asp Asn Ile Met Ser Pro 
            340                 345                 350         


Val Pro Leu Leu Ser 
        355         


<210> 2118
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 2118
Xaa Asn Xaa Glu Lys Gln Leu Gln Tyr Phe Lys Ser Leu Cys Arg Glu 
1               5                   10                  15      


Ile Lys Gln Arg Arg Arg Gly Val Ala Ser Ile Leu Arg Leu Cys Gln 
            20                  25                  30          


His Leu Leu Asp Asp Arg Glu Xaa Cys Asn Leu Asn Ala Asp His Gln 
        35                  40                  45              


Pro Met Gln Leu Ile Ile Val Asn Leu Glu Arg Arg Trp Glu Ala Ile 
    50                  55                  60                  


Val Met Gln Ala Val Gln Trp Gln Xaa Arg Leu Gln Lys Lys Met Gly 
65                  70                  75                  80  


Lys Glu Ser Val Ser Asp Ala Phe Phe Lys His Asn Cys Leu Ser Phe 
                85                  90                  95      


Ser Gln Xaa Lys Asn Asn Ser Phe Arg Leu Gly Asn Gly Val His Leu 
            100                 105                 110         


Ile Asn Gly Phe Xaa Asn 
        115             


<210> 2119
<211> 348
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<400> 2119
Met Glu Arg Pro Glu Ala Gly Gly Ile Asn Ser Asn Glu Cys Glu Asn 
1               5                   10                  15      


Val Ser Arg Lys Lys Lys Met Ser Glu Glu Phe Glu Ala Asn Xaa Met 
            20                  25                  30          


Asp Ser Leu Val Asp Met Pro Phe Ala Xaa Val Asp Ile Gln Asp Asp 
        35                  40                  45              


Cys Gly Ile Xaa Asp Glu Pro Gln Ile Asn Leu Lys Arg Ser Gln Glu 
    50                  55                  60                  


Asn Glu Trp Val Lys Ser Asp Gln Val Lys Lys Arg Lys Lys Lys Arg 
65                  70                  75                  80  


Lys Asp Tyr Gln Pro Asn Tyr Phe Leu Ser Ile Pro Ile Xaa Asn Lys 
                85                  90                  95      


Glu Ile Ile Lys Gly Ile Lys Ile Leu Gln Asn Ala Ile Ile Gln Gln 
            100                 105                 110         


Asp Glu Arg Leu Ala Lys Ala Met Val Ser Asp Gly Ser Phe His Ile 
        115                 120                 125             


Xaa Leu Leu Val Met Gln Leu Leu Asn Glu Asp Glu Val Asn Ile Gly 
    130                 135                 140                 


Ile Asp Ala Leu Leu Glu Leu Lys Pro Phe Ile Glu Glu Leu Leu Gln 
145                 150                 155                 160 


Gly Lys His Leu Xaa Leu Pro Phe Gln Gly Ile Gly Xaa Phe Gly Asn 
                165                 170                 175     


Gln Val Gly Phe Val Lys Leu Ala Glu Gly Asp His Val Asn Ser Leu 
            180                 185                 190         


Leu Glu Ile Ala Glu Xaa Ala Asn Arg Xaa Phe Gln Glu Lys Gly Ile 
        195                 200                 205             


Leu Val Gly Glu Ser Arg Ser Phe Lys Pro His Leu Xaa Phe Met Lys 
    210                 215                 220                 


Leu Ser Lys Ser Pro Trp Leu Arg Lys Asn Gly Val Lys Lys Ile Asp 
225                 230                 235                 240 


Pro Asp Leu Tyr Glu Lys Phe Ile Ser His Arg Phe Gly Glu Glu Ile 
                245                 250                 255     


Leu Tyr Arg Ile Asp Leu Cys Ser Met Leu Lys Lys Lys Gln Ser Asn 
            260                 265                 270         


Gly Tyr Tyr His Cys Glu Ser Ser Ile Val Ile Gly Glu Lys Asn Gly 
        275                 280                 285             


Gly Glu Pro Asp Asp Ala Glu Leu Val Arg Leu Ser Lys Arg Leu Val 
    290                 295                 300                 


Glu Asn Ala Val Leu Lys Ala Val Gln Gln Tyr Leu Glu Glu Xaa Gln 
305                 310                 315                 320 


Asn Lys Asn Lys Pro Gly Glu Gly Ser Ser Val Lys Xaa Glu Ala Ala 
                325                 330                 335     


Asp Gln Asn Gly Asn Asp Asn Glu Asn Asn Arg Lys 
            340                 345             


<210> 2120
<211> 350
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<400> 2120
Met Glu Arg Pro Glu Ala Gly Ile Asn Ser Asn Glu Cys Glu Asn Val 
1               5                   10                  15      


Ser Arg Lys Lys Lys Met Ser Glu Glu Phe Glu Ala Asn Xaa Met Asp 
            20                  25                  30          


Ser Leu Val Asp Met Pro Phe Ala Xaa Val Asp Ile Gln Asp Asp Cys 
        35                  40                  45              


Gly Ile Xaa Asp Glu Pro Gln Ile Asn Leu Lys Arg Ser Gln Glu Asn 
    50                  55                  60                  


Glu Trp Val Lys Ser Asp Gln Val Lys Lys Arg Lys Lys Lys Arg Lys 
65                  70                  75                  80  


Asp Tyr Gln Pro Asn Tyr Phe Leu Ser Ile Pro Ile Xaa Asn Lys Glu 
                85                  90                  95      


Ile Ile Lys Gly Ile Lys Ile Leu Gln Asn Ala Ile Ile Gln Gln Asp 
            100                 105                 110         


Glu Arg Leu Ala Lys Ala Met Val Ser Asp Gly Ser Phe His Ile Xaa 
        115                 120                 125             


Leu Leu Val Met Gln Leu Leu Asn Glu Asp Glu Val Asn Ile Gly Ile 
    130                 135                 140                 


Asp Ala Leu Leu Glu Leu Lys Pro Phe Ile Glu Glu Leu Leu Gln Gly 
145                 150                 155                 160 


Lys His Leu Xaa Leu Pro Phe Gln Gly Ile Gly Xaa Phe Gly Asn Gln 
                165                 170                 175     


Val Gly Phe Val Lys Leu Ala Glu Gly Asp His Val Asn Ser Leu Leu 
            180                 185                 190         


Glu Ile Ala Glu Xaa Ala Asn Arg Xaa Phe Gln Glu Lys Gly Ile Leu 
        195                 200                 205             


Val Gly Glu Ser Arg Ser Phe Lys Pro His Leu Xaa Phe Met Lys Leu 
    210                 215                 220                 


Ser Lys Ser Pro Trp Leu Arg Lys Asn Gly Val Lys Lys Ile Asp Pro 
225                 230                 235                 240 


Asp Leu Tyr Glu Lys Phe Ile Ser His Arg Phe Gly Glu Glu Ile Leu 
                245                 250                 255     


Tyr Arg Ile Asp Leu Cys Ser Met Leu Lys Lys Lys Gln Ser Asn Gly 
            260                 265                 270         


Tyr Tyr His Cys Glu Ser Ser Ile Val Ile Gly Lys Lys Pro Ile Gly 
        275                 280                 285             


Ile Arg Asp Leu Ile Asn Glu Ala Leu His Arg Glu Xaa Met Gly Leu 
    290                 295                 300                 


Lys Ser Lys Val Lys Gln Ile Lys Glu Leu Leu Leu Lys Pro Glu Xaa 
305                 310                 315                 320 


Gln Ala Arg Ile Arg Arg Glu Leu Phe Glu Gly Arg Leu Ile Asn Asn 
                325                 330                 335     


Ser Asn Ser Ala Asn Asp Val Asp Phe Ser Xaa Xaa Leu Xaa 
            340                 345                 350 


<210> 2121
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 2121
Met Gly Gln Leu Cys Cys Phe Pro Phe Ser Arg Asp Glu Gly Lys Ile 
1               5                   10                  15      


Ser Glu Lys Asn Gly Gly Glu Pro Asp Asp Ala Glu Leu Val Arg Leu 
            20                  25                  30          


Ser Lys Arg Leu Val Glu Asn Ala Val Leu Lys Ala Val Gln Gln Tyr 
        35                  40                  45              


Leu Glu Glu Xaa Gln Asn Lys Asn Lys Pro Gly Glu Gly Ser Ser Val 
    50                  55                  60                  


Lys Xaa Glu Ala Ala Asp Gln Asn Gly Asn Asp Asn Glu Asn Asn Arg 
65                  70                  75                  80  


Lys 
    


<210> 2122
<211> 104
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 2122
Met Gly Gln Leu Cys Cys Phe Pro Phe Ser Arg Asp Glu Gly Lys Ile 
1               5                   10                  15      


Ser Glu Leu Glu Ser Ser Ser Ser Ala Val Leu Gln Arg Tyr Ser Lys 
            20                  25                  30          


Asp Ile Pro Ser Trp Ser Ser Gly Glu Lys Asn Gly Gly Glu Pro Asp 
        35                  40                  45              


Asp Ala Glu Leu Val Arg Leu Ser Lys Arg Leu Val Glu Asn Ala Val 
    50                  55                  60                  


Leu Lys Ala Val Gln Gln Tyr Leu Glu Glu Xaa Gln Asn Lys Asn Lys 
65                  70                  75                  80  


Pro Gly Glu Gly Ser Ser Val Lys Xaa Glu Ala Ala Asp Gln Asn Gly 
                85                  90                  95      


Asn Asp Asn Glu Asn Asn Arg Lys 
            100                 


<210> 2123
<211> 84
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<400> 2123
Met Leu Lys Lys Lys Gln Ser Asn Gly Tyr Tyr His Cys Glu Ser Ser 
1               5                   10                  15      


Ile Val Ile Gly Glu Lys Asn Gly Gly Glu Pro Asp Asp Ala Glu Leu 
            20                  25                  30          


Val Arg Leu Ser Lys Arg Leu Val Glu Asn Ala Val Leu Lys Ala Val 
        35                  40                  45              


Gln Gln Tyr Leu Glu Glu Xaa Gln Asn Lys Asn Lys Pro Gly Glu Gly 
    50                  55                  60                  


Ser Ser Val Lys Xaa Glu Ala Ala Asp Gln Asn Gly Asn Asp Asn Glu 
65                  70                  75                  80  


Asn Asn Arg Lys 
                


<210> 2124
<211> 87
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<400> 2124
Met Leu Lys Lys Lys Gln Ser Asn Gly Tyr Tyr His Cys Glu Ser Ser 
1               5                   10                  15      


Ile Val Ile Gly Lys Lys Pro Ile Gly Ile Arg Asp Leu Ile Asn Glu 
            20                  25                  30          


Ala Leu His Arg Glu Xaa Met Gly Leu Lys Ser Lys Val Lys Gln Ile 
        35                  40                  45              


Lys Glu Leu Leu Leu Lys Pro Glu Xaa Gln Ala Arg Ile Arg Arg Glu 
    50                  55                  60                  


Leu Phe Glu Gly Arg Leu Ile Asn Asn Ser Asn Ser Ala Asn Asp Val 
65                  70                  75                  80  


Asp Phe Ser Xaa Xaa Leu Xaa 
                85          


<210> 2125
<211> 51
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<400> 2125
Xaa Xaa Asp Glu Pro Gln Ile Asn Leu Lys Arg Ser Gln Glu Asn Glu 
1               5                   10                  15      


Trp Val Lys Ser Asp Gln Val Lys Lys Arg Lys Lys Lys Arg Lys Asp 
            20                  25                  30          


Tyr Gln Pro Asn Tyr Phe Leu Ser Ile Pro Ile Xaa Asn Lys Glu Arg 
        35                  40                  45              


Ser Arg Cys 
    50      


<210> 2126
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<400> 2126
Met Asp Gln Gly Tyr Gly Gly Tyr Gly Ala Trp Ser Ala Gly Pro Ala 
1               5                   10                  15      


Asn Xaa Gln Gly Ala Tyr Gly Xaa Gly Val Ala Ser Trp Gln Ala Pro 
            20                  25                  30          


Ser Ala Ser Ser Arg Ser Ser Pro Met Xaa Pro Gly Pro Ala Cys Arg 
        35                  40                  45              


Ser Xaa Xaa Pro Xaa Ala Pro Ala Xaa Ala Xaa Xaa Met Ser Ser Xaa 
    50                  55                  60                  


Trp Gly Pro Xaa Ala Met Ala Ala Leu Gly Gly Ser Xaa Val Asn Ala 
65                  70                  75                  80  


Glu Xaa Gln Pro Gly Ser Gly Ala Pro Leu Met Ala Ser Cys Gly Ala 
                85                  90                  95      


Gly Ala Arg Ala Ala Ser Arg Xaa Gly Ala Xaa Leu Ala Pro Ser Cys 
            100                 105                 110         


Ala Ala Xaa Pro Ser Cys Pro Pro Leu Arg Pro Leu Ser Pro Cys Pro 
        115                 120                 125             


Arg Pro Gly Xaa Ser 
    130             


<210> 2127
<211> 692
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<400> 2127
Met Asp Gln Gly Tyr Gly Gly Tyr Gly Ala Trp Ser Ala Gly Pro Ala 
1               5                   10                  15      


Asn Xaa Gln Gly Ala Tyr Gly Xaa Gly Val Ala Ser Trp Gln Gly Tyr 
            20                  25                  30          


Glu Asn Tyr Asn Tyr Tyr Gly Ala Gln Asn Xaa Ser Val Xaa Xaa Gly 
        35                  40                  45              


Ala Xaa Tyr Ser Tyr Gly Pro Ala Ser Trp Glu Ala Ala Lys Ala Asn 
    50                  55                  60                  


Asp Gly Gly Leu Ala Ala Gly Ala Pro Ala Met His Met Ala Ser Tyr 
65                  70                  75                  80  


Gly Pro Glu Pro Cys Xaa Asp Asn Ser Asp Ser Leu Ile Ala Lys Ile 
                85                  90                  95      


Asn Gln Arg Leu Asp Met Met Ser Lys Glu Gly Gly Arg Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Glu Gly Ile Gln Asp Arg Glu Ser Ser Phe Arg Phe 
        115                 120                 125             


Gln Pro Phe Glu Ser Tyr Asp Ser Arg Pro Cys Leu Pro Glu His Asn 
    130                 135                 140                 


Pro Tyr Arg Pro Ser Tyr Ser Tyr Asp Tyr Glu Phe Asp Leu Gly Ser 
145                 150                 155                 160 


Asp Arg Asn Gly Ser Phe Gly Gly Gln Tyr Ser Glu Cys Arg Asp Pro 
                165                 170                 175     


Ala Arg Glu Arg Gly Ser Leu Asp Gly Phe Met Arg Gly Arg Gly Gln 
            180                 185                 190         


Gly Arg Phe Gln Asp Arg Ser Asn Pro Gly Xaa Phe Met Arg Ser Asp 
        195                 200                 205             


Pro Phe Val Pro Pro Ala Ala Ser Ser Glu Pro Leu Ser Xaa Pro Trp 
    210                 215                 220                 


Asn Glu Leu Asn Tyr Val Gly Gly Arg Gly Leu Gly Gly Pro Ser Pro 
225                 230                 235                 240 


Ser Arg Pro Pro Pro Ser Leu Phe Ser Gln Ser Met Ala Pro Asp Tyr 
                245                 250                 255     


Gly Val Met Gly Met Gln Gly Ala Gly Gly Tyr Asp Ser Xaa Met Pro 
            260                 265                 270         


Tyr Gly Cys Gly Arg Ser Gln Pro Arg Met Arg Asp Arg Asp Arg Pro 
        275                 280                 285             


Lys Arg Arg Gly Phe Asp Arg Phe Gly Pro Asp Gly Xaa Gly Arg Lys 
    290                 295                 300                 


Arg Lys Gln Phe Gln Leu Tyr Glu Glu Pro Asp Xaa Lys Leu Ala Arg 
305                 310                 315                 320 


Val Asp Ser Glu Gly Asp Phe Ser Glu Asn Asp Asp Ala Ala Gly Asp 
                325                 330                 335     


Phe Arg Ser Gly Asp Glu Glu Phe Lys Gly Glu Asp Glu Leu Cys Asp 
            340                 345                 350         


Ser Gly Arg Gln Arg Gly Glu Lys Glu Asp Glu Asp Glu Asp Val Lys 
        355                 360                 365             


Lys Arg Arg Glu Lys Gln Arg Arg Arg Asp Arg Xaa Arg Asp Arg Ala 
    370                 375                 380                 


Ala Asp Arg Ile Gln Phe Ala Cys Ser Val Cys Lys Phe Arg Ser Phe 
385                 390                 395                 400 


Asp Asp Glu Glu Ile Gln Lys His Leu Gln Ser Lys Phe His Lys Glu 
                405                 410                 415     


Xaa Leu Arg Phe Ile Ser Xaa Lys Leu Pro Asp Lys Xaa Val Glu Phe 
            420                 425                 430         


Leu Gln Glu Tyr Ile Val Asn Arg Asn Lys Lys Ile Glu Lys Arg Arg 
        435                 440                 445             


Gln Glu Leu Met Glu Lys Glu Xaa Ala Lys Pro Lys Pro Asp Pro Phe 
    450                 455                 460                 


Lys Gly Ile Gly Gln Glu His Phe Phe Lys Lys Ile Glu Ala Ala His 
465                 470                 475                 480 


Cys Leu Ala Cys Asp Met Leu Ile Pro Ala Gln Pro Gln Leu Leu Gln 
                485                 490                 495     


Arg His Leu His Ser Val Asp His Asn His Asn Arg Arg Leu Ala Ala 
            500                 505                 510         


Glu Gln Phe Lys Lys Xaa Ser Leu His Val Ala Lys Ser Val Leu Asn 
        515                 520                 525             


Asn Arg His Ile Val Lys Met Leu Glu Lys Tyr Leu Lys Gly Glu Asp 
    530                 535                 540                 


Pro Phe Xaa Ser Glu Xaa Val Asp Pro Glu Met Glu Gly Asp Asp Asn 
545                 550                 555                 560 


Leu Gly Gly Glu Asp Lys Lys Glu Xaa Pro Glu Glu Val Ala Ala Asp 
                565                 570                 575     


Val Leu Ala Glu Val Ile Xaa Ala Ala Val Arg Ala Val Asp Gly Glu 
            580                 585                 590         


Gly Ala Pro Ala Pro Glu Ser Ser Gly Glu Pro Ala Glu Asp Glu Gly 
        595                 600                 605             


Pro Xaa Asp Xaa Ala Glu Ala Gly Ser Asp Pro Gln Ala Glu Gln Leu 
    610                 615                 620                 


Leu Glu Glu Gln Val Pro Cys Gly Xaa Ala His Glu Lys Gly Val Pro 
625                 630                 635                 640 


Lys Ala Arg Ser Glu Ala Ala Glu Ala Gly Asn Gly Ala Glu Xaa Met 
                645                 650                 655     


Ala Ala Glu Ala Glu Ser Ala Gln Xaa Arg Val Ala Pro Ala Pro Ala 
            660                 665                 670         


Ala Ala Asp Ala Glu Val Glu Gln Xaa Asp Ala Glu Ser Lys Asp Ala 
        675                 680                 685             


Val Pro Xaa Glu 
    690         


<210> 2128
<211> 178
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<400> 2128
Xaa Arg Gly Arg Gly Gln Gly Arg Phe Gln Asp Arg Ser Asn Pro Gly 
1               5                   10                  15      


Xaa Phe Met Arg Ser Asp Pro Phe Val Pro Pro Ala Ala Ser Ser Glu 
            20                  25                  30          


Pro Leu Ser Xaa Pro Trp Asn Glu Leu Asn Tyr Val Gly Gly Arg Gly 
        35                  40                  45              


Leu Gly Gly Pro Ser Pro Ser Arg Pro Pro Pro Ser Leu Phe Ser Gln 
    50                  55                  60                  


Ser Met Ala Pro Asp Tyr Gly Val Met Gly Met Gln Gly Ala Gly Gly 
65                  70                  75                  80  


Tyr Asp Ser Xaa Met Pro Tyr Gly Cys Gly Arg Ser Gln Pro Arg Met 
                85                  90                  95      


Arg Asp Arg Asp Arg Pro Lys Arg Arg Gly Phe Asp Arg Phe Gly Pro 
            100                 105                 110         


Asp Gly Xaa Gly Arg Lys Arg Lys Gln Phe Gln Leu Tyr Glu Glu Pro 
        115                 120                 125             


Asp Xaa Lys Leu Ala Arg Val Asp Ser Glu Gly Asp Phe Ser Glu Asn 
    130                 135                 140                 


Asp Asp Ala Ala Gly Asp Phe Arg Ser Gly Asp Glu Glu Phe Lys Gly 
145                 150                 155                 160 


Glu Asp Glu Leu Cys Asp Ser Gly Arg Gln Arg Gly Pro Ala Xaa Tyr 
                165                 170                 175     


Pro Gly 
        


<210> 2129
<211> 1769
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1017)..(1017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1161)..(1161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1222)..(1222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1245)..(1245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1314)..(1315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1319)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1323)..(1323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1387)..(1387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1411)..(1411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1425)..(1425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1431)..(1431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1442)..(1442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1449)..(1449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1507)..(1507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1534)..(1534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1543)..(1543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1602)..(1602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1635)..(1635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1656)..(1656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1675)..(1676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1699)..(1699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1723)..(1723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1727)..(1727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1738)..(1738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1747)..(1748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1758)..(1758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1768)..(1768)
<223> Selenocysteine

<400> 2129
Glu Lys Leu Glu Phe Arg Val Arg Glu Leu Glu Gln Ala Leu Leu Val 
1               5                   10                  15      


Glu Asp Arg Lys His Phe Gly Ala Val Glu Ala Lys Pro Glu Leu Ser 
            20                  25                  30          


Leu Glu Val Gln Leu Gln Ala Glu Arg Asp Ala Ile Asp Arg Lys Glu 
        35                  40                  45              


Lys Glu Ile Xaa Asn Leu Glu Glu Gln Leu Glu Gln Phe Arg Glu Glu 
    50                  55                  60                  


Leu Glu Asn Lys Asn Glu Glu Val Gln Gln Leu His Met Gln Leu Glu 
65                  70                  75                  80  


Ile Gln Lys Lys Glu Ser Xaa Xaa Arg Leu Gln Glu Leu Glu Gln Glu 
                85                  90                  95      


Asn Lys Leu Phe Lys Asp Asp Met Glu Lys Leu Gly Leu Ala Ile Lys 
            100                 105                 110         


Glu Ser Asp Ala Met Ser Xaa Gln Asp Gln His Val Leu Phe Gly Lys 
        115                 120                 125             


Phe Ala Gln Ile Ile Gln Glu Lys Glu Val Glu Ile Asp Gln Leu Asn 
    130                 135                 140                 


Glu Gln Val Xaa Lys Leu Gln Gln Gln Leu Lys Ile Xaa Xaa Asp Asn 
145                 150                 155                 160 


Lys Val Ile Glu Glu Lys Asn Glu Leu Ile Arg Asp Leu Glu Xaa Gln 
                165                 170                 175     


Ile Glu Cys Leu Met Ser Asp Gln Glu Cys Val Lys Arg Asn Arg Glu 
            180                 185                 190         


Glu Glu Ile Glu Gln Leu Asn Glu Val Ile Glu Lys Leu Gln Gln Glu 
        195                 200                 205             


Leu Ala Asn Ile Gly Gln Lys Xaa Ser Met Asn Ala His Ser Leu Ser 
    210                 215                 220                 


Glu Glu Ala Asp Ser Leu Lys His Gln Leu Asp Val Val Ile Ala Glu 
225                 230                 235                 240 


Lys Leu Ala Leu Glu Gln Gln Val Glu Xaa Ala Asn Glu Glu Met Xaa 
                245                 250                 255     


Phe Met Lys Asn Val Leu Lys Glu Xaa Asn Phe Lys Met Asn Gln Leu 
            260                 265                 270         


Xaa Gln Glu Leu Phe Ser Leu Lys Arg Glu Arg Glu Ser Val Glu Lys 
        275                 280                 285             


Ile Gln Ser Ile Pro Glu Asn Ser Val Asn Val Ala Ile Asp His Leu 
    290                 295                 300                 


Ser Lys Asp Lys Pro Glu Leu Glu Val Val Leu Xaa Glu Asp Ala Leu 
305                 310                 315                 320 


Lys Ser Leu Glu Asn Gln Xaa Tyr Phe Lys Ser Phe Glu Glu Asn Gly 
                325                 330                 335     


Lys Gly Ser Ile Ile Asn Leu Glu Xaa Arg Leu Leu Gln Leu Glu Ser 
            340                 345                 350         


Xaa Val Ser Ala Lys Asp Leu Glu Leu Xaa Gln Cys Tyr Lys Gln Ile 
        355                 360                 365             


Lys Asp Met Gln Glu Gln Gly Gln Phe Glu Xaa Glu Met Leu Gln Lys 
    370                 375                 380                 


Lys Ile Val Asn Leu Gln Lys Ile Val Glu Glu Lys Val Ala Ala Ala 
385                 390                 395                 400 


Leu Val Ser Gln Ile Gln Leu Glu Ala Val Gln Glu Tyr Ala Lys Phe 
                405                 410                 415     


Cys Gln Asp Asn Gln Xaa Ile Ser Ser Glu Pro Glu Arg Xaa Asn Ile 
            420                 425                 430         


Gln Asn Leu Asn Gln Leu Arg Glu Asp Glu Leu Gly Ser Asp Ile Ser 
        435                 440                 445             


Ala Leu Xaa Leu Arg Ile Ser Glu Leu Glu Ser Gln Val Val Glu Met 
    450                 455                 460                 


His Xaa Ser Leu Ile Leu Glu Lys Glu Gln Val Glu Ile Ala Glu Lys 
465                 470                 475                 480 


Asn Val Leu Glu Lys Glu Lys Lys Leu Leu Glu Leu Gln Lys Leu Leu 
                485                 490                 495     


Glu Gly Asn Glu Lys Lys Gln Arg Glu Lys Glu Lys Lys Arg Ser Pro 
            500                 505                 510         


Gln Asp Val Glu Val Leu Lys Xaa Xaa Xaa Glu Leu Phe His Ser Asn 
        515                 520                 525             


Glu Glu Ser Gly Phe Phe Asn Glu Leu Glu Ala Leu Arg Ala Glu Ser 
    530                 535                 540                 


Val Ala Xaa Lys Ala Glu Leu Ala Ser Tyr Lys Glu Lys Ala Glu Lys 
545                 550                 555                 560 


Leu Gln Glu Glu Leu Leu Val Lys Glu Xaa Asn Met Xaa Ser Leu Gln 
                565                 570                 575     


Lys Asp Leu Ser Gln Val Arg Asp His Leu Ala Glu Ala Lys Glu Lys 
            580                 585                 590         


Leu Ser Ile Leu Glu Lys Glu Asp Glu Xaa Glu Val Gln Glu Ser Lys 
        595                 600                 605             


Lys Ala Cys Met Phe Glu Pro Leu Pro Ile Lys Leu Ser Lys Ser Ile 
    610                 615                 620                 


Ala Ser Gln Xaa Asp Gly Xaa Leu Lys Ile Ser Ser Ser Asn Gln Xaa 
625                 630                 635                 640 


Pro Gln Ile Leu Val Lys Asn Ala Gly Ile Gln Ile Asn Leu Gln Ser 
                645                 650                 655     


Glu Cys Ser Ser Glu Glu Val Xaa Glu Ile Ile Ser Gln Phe Xaa Glu 
            660                 665                 670         


Lys Ile Glu Lys Met Gln Glu Leu His Ala Ala Glu Ile Leu Asp Met 
        675                 680                 685             


Glu Ser Arg His Ile Ser Glu Xaa Glu Xaa Leu Lys Arg Glu His Tyr 
    690                 695                 700                 


Val Ala Val Gln Leu Leu Lys Glu Glu Cys Gly Xaa Leu Lys Ala Val 
705                 710                 715                 720 


Ile Gln Cys Leu Arg Ser Lys Glu Gly Ser Ser Ile Pro Glu Leu Ala 
                725                 730                 735     


His Ser Asp Ala Tyr Gln Xaa Arg Glu Ile Cys Ser Ser Asp Ser Gly 
            740                 745                 750         


Ser Asp Trp Gly Gln Gly Ile Tyr Leu Xaa His Ser Gln Gly Phe Asp 
        755                 760                 765             


Ile Ala Ser Glu Gly Arg Gly Glu Glu Ser Glu Ser Ala Xaa Asp Ser 
    770                 775                 780                 


Phe Pro Lys Lys Ile Lys Gly Leu Leu Arg Ala Val His Asn Glu Gly 
785                 790                 795                 800 


Met Gln Val Leu Ser Leu Xaa Glu Ser Pro Tyr Ser Asp Gly Glu Asp 
                805                 810                 815     


His Ser Ile Gln Gln Val Ser Glu Pro Trp Leu Glu Glu Arg Lys Ala 
            820                 825                 830         


Tyr Ile Asn Xaa Ile Ser Ser Leu Lys Asp Leu Ile Xaa Lys Met Gln 
        835                 840                 845             


Leu Gln Arg Glu Ala Glu Val Tyr Asp Ser Ser Gln Ser His Glu Ser 
    850                 855                 860                 


Phe Ser Asp Trp Arg Gly Glu Leu Leu Leu Ala Leu Gln Gln Val Phe 
865                 870                 875                 880 


Leu Glu Glu Arg Ser Val Leu Leu Ala Ala Phe Arg Xaa Glu Leu Xaa 
                885                 890                 895     


Ala Leu Gly Xaa Xaa Asp Ala Val Gly Leu Leu Asn Cys Leu Glu Gln 
            900                 905                 910         


Arg Ile Gln Glu Gln Gly Val Glu Tyr Gln Ala Ala Met Glu Cys Leu 
        915                 920                 925             


Gln Lys Ala Asp Arg Arg Ser Leu Leu Ser Glu Ile Gln Ala Leu His 
    930                 935                 940                 


Ala Gln Met Asn Gly Arg Lys Ile Xaa Leu Lys Arg Glu Gln Glu Ser 
945                 950                 955                 960 


Glu Lys Pro Ser Gln Glu Leu Leu Glu Tyr Asn Ile Gln Gln Lys Gln 
                965                 970                 975     


Ser Gln Met Leu Glu Met Gln Val Glu Leu Ser Ser Met Lys Asp Arg 
            980                 985                 990         


Ala Xaa Glu Leu Gln Glu Gln Leu  Ser Ser Glu Lys Met  Val Val Ala 
        995                 1000                 1005             


Glu Leu  Lys Ser Glu Leu Ala  Gln Xaa Lys Leu Glu  Leu Glu Xaa 
    1010                 1015                 1020             


Xaa Leu  Lys Ala Gln His Lys  His Leu Lys Glu Leu  Glu Ala Phe 
    1025                 1030                 1035             


Arg Leu  Glu Val Lys Asp Lys  Xaa Asp Glu Val His  Leu Leu Asn 
    1040                 1045                 1050             


Asp Xaa  Leu Ala Ser Glu Gln  Lys Lys Ser Arg Glu  Leu Gln Trp 
    1055                 1060                 1065             


Ala Leu  Glu Lys Glu Lys Ala  Lys Leu Gly Arg Ser  Glu Glu Arg 
    1070                 1075                 1080             


Asp Lys  Glu Glu Leu Glu Asp  Leu Lys Phe Ser Leu  Glu Ser Gln 
    1085                 1090                 1095             


Lys Gln  Arg Asn Leu Gln Leu  Asn Leu Leu Leu Glu  Gln Gln Lys 
    1100                 1105                 1110             


Gln Leu  Leu Asn Glu Ser Gln  Gln Lys Ile Glu Ser  Gln Arg Met 
    1115                 1120                 1125             


Leu Tyr  Asp Ala Gln Leu Ser  Glu Glu Gln Gly Arg  Asn Leu Glu 
    1130                 1135                 1140             


Leu Gln  Val Leu Leu Glu Ser  Glu Lys Val Arg Ile  Arg Glu Met 
    1145                 1150                 1155             


Ser Ser  Xaa Leu Asp Arg Glu  Arg Glu Leu His Ala  Gln Leu Gln 
    1160                 1165                 1170             


Ser Ser  Asp Gly Xaa Gly Gln  Ser Arg Pro Pro Leu  Pro Ser Glu 
    1175                 1180                 1185             


Asp Leu  Leu Lys Glu Leu Gln  Lys Gln Leu Glu Glu  Lys His Ser 
    1190                 1195                 1200             


Arg Ile  Val Glu Leu Leu Asn  Glu Xaa Glu Lys Tyr  Lys Leu Asp 
    1205                 1210                 1215             


Ser Leu  Gln Xaa Arg Gln Gln  Met Glu Lys Asp Arg  Gln Val His 
    1220                 1225                 1230             


Arg Lys  Xaa Leu Gln Xaa Glu  Gln Glu Ala Asn Xaa  Glu Gly Gln 
    1235                 1240                 1245             


Lys Lys  Met His Glu Leu Gln  Ser Lys Val Glu Asp  Leu Gln Arg 
    1250                 1255                 1260             


Gln Leu  Glu Glu Lys Arg Gln  Gln Val Tyr Lys Leu  Asp Leu Glu 
    1265                 1270                 1275             


Gly Gln  Arg Leu Gln Gly Ile  Met Gln Glu Phe Gln  Lys Gln Glu 
    1280                 1285                 1290             


Leu Glu  Arg Glu Glu Lys Arg  Glu Ser Arg Arg Ile  Leu Tyr Gln 
    1295                 1300                 1305             


Asn Leu  Asn Glu Pro Xaa Xaa  Trp Ser Leu Xaa Ser  Asp Arg Xaa 
    1310                 1315                 1320             


Arg Asn  Trp Val Leu Gln Gln  Lys Ile Glu Gly Glu  Xaa Lys Glu 
    1325                 1330                 1335             


Ser Asn  Tyr Ala Lys Leu Ile  Glu Met Asn Gly Gly  Gly Xaa Gly 
    1340                 1345                 1350             


Cys Asn  His Glu Leu Glu Met  Ile Arg Gln Lys Leu  Gln Cys Val 
    1355                 1360                 1365             


Ala Ser  Lys Leu Gln Val Leu  Pro Gln Lys Ala Ser  Glu Arg Leu 
    1370                 1375                 1380             


Gln Phe  Glu Xaa Ala Asp Asp  Glu Asp Phe Ile Trp  Val Gln Glu 
    1385                 1390                 1395             


Asn Ile  Asp Glu Ile Ile Leu  Gln Leu Gln Lys Leu  Xaa Gly Gln 
    1400                 1405                 1410             


Gln Gly  Glu Glu Pro Ser Leu  Val Ser Pro Ser Xaa  Ser Cys Gly 
    1415                 1420                 1425             


Ser Leu  Xaa Glu Arg Leu Leu  Arg Gln Asn Ala Glu  Leu Xaa Gly 
    1430                 1435                 1440             


His Ile  Ser Gln Leu Xaa Glu  Glu Lys Asn Asp Leu  Arg Asn Met 
    1445                 1450                 1455             


Val Met  Lys Leu Glu Glu Gln  Ile Arg Trp Tyr Arg  Gln Xaa Gly 
    1460                 1465                 1470             


Ala Gly  Arg Asp Asn Ser Ser  Arg Phe Ser Leu Asn  Gly Gly Ala 
    1475                 1480                 1485             


Asn Ile  Glu Ala Ile Ile Ala  Ser Glu Lys Glu Val  Trp Asn Arg 
    1490                 1495                 1500             


Glu Lys  Leu Xaa Leu Gln Lys  Ser Leu Lys Arg Ala  Glu Ala Glu 
    1505                 1510                 1515             


Val Tyr  Lys Leu Lys Ala Glu  Leu Arg Asn Asp Ser  Leu Leu Gln 
    1520                 1525                 1530             


Xaa Leu  Ser Pro Asp Ser Glu  His Val Xaa Leu Lys  Arg Ile Tyr 
    1535                 1540                 1545             


Gly Lys  Tyr Leu Arg Ala Glu  Ser Phe Arg Lys Ala  Leu Ile Tyr 
    1550                 1555                 1560             


Gln Lys  Lys Tyr Leu Leu Leu  Leu Leu Gly Gly Phe  Gln Glu Cys 
    1565                 1570                 1575             


Glu Asp  Ala Xaa Leu Ala Leu  Leu Ala Arg Met Gly  Gly Gln Pro 
    1580                 1585                 1590             


Ala Phe  Xaa Asp Leu Glu Val  Ile Xaa Asn Arg Pro  Lys Gly Phe 
    1595                 1600                 1605             


Xaa Arg  Phe Arg Ser Ala Val  Arg Val Ser Ile Ala  Ile Ser Arg 
    1610                 1615                 1620             


Met Lys  Phe Leu Val Arg Arg  Trp His Arg Val Xaa  Gly Ser Val 
    1625                 1630                 1635             


Ser Ile  Asn Ile Asn Arg Asp  Gly Phe Gly Leu Asn  Gln Gly Ala 
    1640                 1645                 1650             


Glu Lys  Xaa Asp Ser Phe Tyr  His Ser Ser Gly Gly  Leu Glu Leu 
    1655                 1660                 1665             


Tyr Gly  Glu Pro Arg His Xaa  Xaa Tyr Arg Ser Arg  Ser Asp Leu 
    1670                 1675                 1680             


Asp Tyr  Ile Arg Ser Pro Leu  Pro Phe Gln Asn Arg  Tyr Pro Gly 
    1685                 1690                 1695             


Xaa Pro  Ala Asp Phe Asn Pro  Gly Ser Leu Ala Cys  Ser Gln Leu 
    1700                 1705                 1710             


Gln Asn  Tyr Asp Pro Asp Arg  Ala Leu Xaa Asp Tyr  Ile Xaa Arg 
    1715                 1720                 1725             


Leu Glu  Ala Leu Gln Arg Arg  Leu Gly Xaa Ile Gln  Ser Gly Ala 
    1730                 1735                 1740             


Leu Ser  Leu Xaa Xaa Ser Trp  Gln His His Ser Ala  Arg Pro Xaa 
    1745                 1750                 1755             


Ala Pro  Leu Ser Leu Lys Phe  Phe His Xaa His 
    1760                 1765                 


<210> 2130
<211> 314
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<400> 2130
Met Glu Asp Glu Glu Arg Gln Lys Lys Leu Glu Ala Gly Lys Ala Lys 
1               5                   10                  15      


Leu Ala Gln Phe Arg Gln Arg Lys Ala Gln Ser Asp Gly Gln Ser Pro 
            20                  25                  30          


Ser Lys Lys Gln Lys Lys Lys Arg Lys Xaa Ser Ser Ser Lys His Asp 
        35                  40                  45              


Val Ser Ala His His Asp Leu Asn Ile Asp Gln Ser Gln Cys Asn Glu 
    50                  55                  60                  


Met Tyr Ile Asn Ser Ser Gln Arg Val Glu Ser Xaa Val Ile Pro Glu 
65                  70                  75                  80  


Ser Xaa Ile Met Arg Xaa Leu His Ser Gly Glu Ile Xaa Ser His Glu 
                85                  90                  95      


Gln Gly Phe Ser Val Glu Leu Glu Ser Glu Ile Ser Xaa Xaa Ala Asp 
            100                 105                 110         


Asp Cys Ser Ser Glu Val Asn Gly Cys Ser Phe Val Met Arg Xaa Gly 
        115                 120                 125             


Lys Pro Xaa Asn Leu Leu Arg Glu Glu Glu Phe Gly Val Asp Asp Ser 
    130                 135                 140                 


Tyr Ser Glu Gln Gly Ala Gln Asp Ser Pro Xaa His Leu Glu Met Met 
145                 150                 155                 160 


Glu Ser Glu Leu Ala Gly Lys Gln His Glu Ile Glu Glu Leu Asn Arg 
                165                 170                 175     


Glu Leu Glu Glu Met Arg Val Xaa Tyr Gly Xaa Glu Gly Leu Gln Gln 
            180                 185                 190         


Leu Gln Glu Phe Glu Ala Ala Ile Lys Gln Arg Asp Gly Ile Ile Xaa 
        195                 200                 205             


Gln Leu Xaa Ala Asn Leu Gln Gln Ala Arg Arg Glu Lys Asp Glu Xaa 
    210                 215                 220                 


Met Arg Glu Phe Leu Glu Leu Xaa Glu Gln Ser Gln Lys Leu Gln Ile 
225                 230                 235                 240 


Gln Phe Gln Gln Leu Gln Ala Ser Glu Xaa Leu Arg Asn Ser Xaa His 
                245                 250                 255     


Ser Ser Xaa Ala Ala Asp Leu Leu Gln Ala Lys Gln Gln Ile Leu Xaa 
            260                 265                 270         


His Gln Gln Gln Leu Glu Glu Gln Asp His Leu Leu Glu Asp Tyr Gln 
        275                 280                 285             


Lys Lys Lys Glu Asp Phe Xaa Met Gln Ile Ser Phe Leu Gln Glu Lys 
    290                 295                 300                 


Ile Lys Val Tyr Glu Met Val Cys Leu Phe 
305                 310                 


<210> 2131
<211> 3126
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1357)..(1357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1379)..(1379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1392)..(1392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1399)..(1399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1413)..(1413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1426)..(1426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1459)..(1459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1471)..(1471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1502)..(1502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1505)..(1505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1558)..(1558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1605)..(1605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1652)..(1652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1694)..(1695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1701)..(1701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1741)..(1741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1744)..(1744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1768)..(1768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1772)..(1772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1786)..(1786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1817)..(1817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1827)..(1827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1829)..(1829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1843)..(1843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1885)..(1885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1895)..(1895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1951)..(1951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1999)..(1999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2061)..(2061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2075)..(2075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2119)..(2119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2159)..(2159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2194)..(2195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2226)..(2226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2255)..(2255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2264)..(2265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2282)..(2282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2323)..(2323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2357)..(2357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2363)..(2363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2372)..(2372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2380)..(2380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2423)..(2423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2434)..(2434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2452)..(2452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2460)..(2460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2469)..(2469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2486)..(2486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2529)..(2529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2537)..(2537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2558)..(2558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2573)..(2573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2627)..(2629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2654)..(2654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2677)..(2677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2680)..(2680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2709)..(2709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2735)..(2735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2738)..(2738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2747)..(2747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2771)..(2771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2778)..(2778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2803)..(2803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2805)..(2805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2823)..(2823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2850)..(2850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2869)..(2869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2889)..(2889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2914)..(2914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2943)..(2943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2952)..(2952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3000)..(3000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3003)..(3003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3007)..(3008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3060)..(3060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3107)..(3107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3118)..(3118)
<223> Selenocysteine

<400> 2131
Met Glu Asp Glu Glu Arg Gln Lys Lys Leu Glu Ala Gly Lys Ala Lys 
1               5                   10                  15      


Leu Ala Gln Phe Arg Gln Arg Lys Ala Gln Ser Asp Gly Gln Ser Pro 
            20                  25                  30          


Ser Lys Lys Gln Lys Lys Lys Arg Lys Xaa Ser Ser Ser Lys His Asp 
        35                  40                  45              


Val Ser Ala His His Asp Leu Asn Ile Asp Gln Ser Gln Cys Asn Glu 
    50                  55                  60                  


Met Tyr Ile Asn Ser Ser Gln Arg Val Glu Ser Xaa Val Ile Pro Glu 
65                  70                  75                  80  


Ser Xaa Ile Met Arg Xaa Leu His Ser Gly Glu Ile Xaa Ser His Glu 
                85                  90                  95      


Gln Gly Phe Ser Val Glu Leu Glu Ser Glu Ile Ser Xaa Xaa Ala Asp 
            100                 105                 110         


Asp Cys Ser Ser Glu Val Asn Gly Cys Ser Phe Val Met Arg Xaa Gly 
        115                 120                 125             


Lys Pro Xaa Asn Leu Leu Arg Glu Glu Glu Phe Gly Val Asp Asp Ser 
    130                 135                 140                 


Tyr Ser Glu Gln Gly Ala Gln Asp Ser Pro Xaa His Leu Glu Met Met 
145                 150                 155                 160 


Glu Ser Glu Leu Ala Gly Lys Gln His Glu Ile Glu Glu Leu Asn Arg 
                165                 170                 175     


Glu Leu Glu Glu Met Arg Val Xaa Tyr Gly Xaa Glu Gly Leu Gln Gln 
            180                 185                 190         


Leu Gln Glu Phe Glu Ala Ala Ile Lys Gln Arg Asp Gly Ile Ile Xaa 
        195                 200                 205             


Gln Leu Xaa Ala Asn Leu Gln Gln Ala Arg Arg Glu Lys Asp Glu Xaa 
    210                 215                 220                 


Met Arg Glu Phe Leu Glu Leu Xaa Glu Gln Ser Gln Lys Leu Gln Ile 
225                 230                 235                 240 


Gln Phe Gln Gln Leu Gln Ala Ser Glu Xaa Leu Arg Asn Ser Xaa His 
                245                 250                 255     


Ser Ser Xaa Ala Ala Asp Leu Leu Gln Ala Lys Gln Gln Ile Leu Xaa 
            260                 265                 270         


His Gln Gln Gln Leu Glu Glu Gln Asp His Leu Leu Glu Asp Tyr Gln 
        275                 280                 285             


Lys Lys Lys Glu Asp Phe Xaa Met Gln Ile Ser Phe Leu Gln Glu Lys 
    290                 295                 300                 


Ile Lys Val Tyr Glu Met Glu Gln Asp Lys Lys Val Glu Asn Ser Asn 
305                 310                 315                 320 


Lys Glu Glu Ile Gln Glu Lys Glu Xaa Ile Ile Glu Glu Leu Asn Xaa 
                325                 330                 335     


Lys Ile Ile Glu Glu Glu Lys Lys Xaa Leu Glu Leu Lys Asp Lys Leu 
            340                 345                 350         


Xaa Xaa Ala Asp Lys Leu Leu Gly Glu Leu Gln Glu Gln Ile Val Gln 
        355                 360                 365             


Lys Asn Gln Glu Ile Lys Asn Met Lys Leu Glu Leu Xaa Asn Ser Lys 
    370                 375                 380                 


Gln Lys Glu Arg Gln Ser Ser Glu Glu Ile Lys Gln Leu Met Gly Xaa 
385                 390                 395                 400 


Val Glu Glu Leu Gln Lys Arg Asn His Lys Asp Ser Gln Phe Glu Xaa 
                405                 410                 415     


Asp Ile Val Gln Arg Met Glu Gln Glu Xaa Gln Arg Lys Leu Glu Gln 
            420                 425                 430         


Leu Arg Ala Glu Leu Asp Glu Met Tyr Gly Gln Gln Ile Val Gln Met 
        435                 440                 445             


Lys Gln Glu Leu Ile Arg Gln His Met Ala Gln Met Glu Glu Met Lys 
    450                 455                 460                 


Xaa Arg His Lys Gly Glu Met Glu Asn Ala Leu Arg Ser Tyr Ser Asn 
465                 470                 475                 480 


Ile Xaa Val Asn Glu Asp Gln Ile Lys Leu Met Asn Val Ala Ile Asn 
                485                 490                 495     


Glu Leu Asn Ile Lys Leu Gln Asp Xaa Asn Ser Gln Lys Glu Lys Leu 
            500                 505                 510         


Lys Glu Glu Leu Gly Leu Ile Leu Glu Glu Lys Cys Ala Leu Gln Arg 
        515                 520                 525             


Gln Leu Glu Asp Leu Val Glu Glu Leu Ser Phe Ser Arg Glu Gln Ile 
    530                 535                 540                 


Gln Arg Ala Arg Gln Xaa Ile Ala Glu Gln Glu Ser Lys Leu Asn Glu 
545                 550                 555                 560 


Ala His Lys Ser Leu Ser Xaa Val Glu Asp Leu Lys Ala Glu Ile Val 
                565                 570                 575     


Ser Ala Ser Glu Ser Arg Lys Glu Leu Glu Leu Lys His Glu Ala Glu 
            580                 585                 590         


Val Xaa Asn Tyr Lys Ile Lys Leu Glu Met Leu Glu Lys Glu Lys Asn 
        595                 600                 605             


Ala Val Leu Asp Arg Met Ala Glu Ser Gln Glu Ala Glu Leu Glu Arg 
    610                 615                 620                 


Leu Arg Xaa Gln Leu Leu Phe Ser His Glu Glu Glu Leu Ser Lys Leu 
625                 630                 635                 640 


Lys Glu Asp Leu Glu Ile Glu His Arg Ile Asn Ile Glu Lys Leu Lys 
                645                 650                 655     


Asp Asn Leu Gly Ile His Tyr Lys Gln Gln Ile Asp Gly Leu Gln Asn 
            660                 665                 670         


Glu Met Ser Gln Lys Ile Glu Xaa Met Gln Phe Glu Lys Asp Asn Leu 
        675                 680                 685             


Ile Xaa Lys Gln Asn Gln Leu Ile Leu Glu Ile Ser Lys Leu Lys Asp 
    690                 695                 700                 


Leu Gln Gln Ser Leu Val Asn Ser Lys Ser Glu Glu Met Xaa Leu Gln 
705                 710                 715                 720 


Ile Asn Glu Leu Gln Lys Glu Ile Glu Ile Leu Arg Gln Glu Glu Lys 
                725                 730                 735     


Glu Lys Gly Xaa Leu Glu Gln Glu Val Gln Glu Leu Gln Leu Lys Xaa 
            740                 745                 750         


Glu Leu Leu Glu Lys Gln Met Lys Glu Lys Glu Asn Asp Leu Gln Glu 
        755                 760                 765             


Lys Phe Ala Gln Leu Glu Ala Glu Asn Ser Ile Leu Lys Asp Glu Lys 
    770                 775                 780                 


Lys Xaa Leu Glu Asp Met Leu Lys Ile His Xaa Pro Val Ser Gln Glu 
785                 790                 795                 800 


Glu Arg Leu Ile Phe Leu Asp Ser Ile Lys Ser Lys Ser Lys Asp Ser 
                805                 810                 815     


Val Trp Glu Lys Glu Ile Glu Ile Leu Ile Glu Glu Asn Glu Asp Leu 
            820                 825                 830         


Lys Gln Gln Cys Ile Gln Leu Asn Glu Glu Ile Glu Lys Gln Arg Asn 
        835                 840                 845             


Xaa Phe Ser Phe Ala Glu Lys Asn Phe Glu Val Asn Tyr Gln Glu Leu 
    850                 855                 860                 


Gln Glu Glu Tyr Ala Cys Leu Leu Lys Val Lys Asp Asp Leu Glu Asp 
865                 870                 875                 880 


Ser Lys Asn Lys Gln Glu Leu Glu Tyr Lys Ser Lys Leu Lys Ala Leu 
                885                 890                 895     


Asn Glu Glu Leu His Leu Gln Arg Ile Asn Pro Xaa Xaa Val Lys Met 
            900                 905                 910         


Lys Ser Ser Val Phe Asp Glu Asp Lys Xaa Phe Val Ala Glu Xaa Leu 
        915                 920                 925             


Glu Met Gly Glu Val Val Glu Lys Asp Xaa Xaa Glu Leu Met Glu Lys 
    930                 935                 940                 


Leu Glu Val Xaa Lys Arg Glu Lys Leu Glu Leu Ser Gln Arg Leu Ser 
945                 950                 955                 960 


Asp Leu Ser Glu Gln Leu Lys Gln Lys His Gly Glu Ile Ser Phe Leu 
                965                 970                 975     


Asn Glu Glu Val Lys Ser Leu Lys Gln Glu Lys Glu Gln Val Ser Leu 
            980                 985                 990         


Arg Cys Arg Glu Leu Glu Ile Ile  Ile Asn His Asn Arg  Ala Glu Asn 
        995                 1000                 1005             


Val Gln  Ser Cys Asp Xaa Gln  Val Ser Ser Leu Leu  Asp Gly Val 
    1010                 1015                 1020             


Val Xaa  Met Xaa Ser Arg Gly  Ala Glu Gly Ser Val  Ser Lys Val 
    1025                 1030                 1035             


Asn Lys  Ser Phe Gly Glu Glu  Ser Lys Ile Met Val  Glu Asp Lys 
    1040                 1045                 1050             


Val Ser  Phe Glu Asn Met Xaa  Val Gly Glu Glu Ser  Lys Gln Glu 
    1055                 1060                 1065             


Gln Leu  Ile Leu Asp His Leu  Pro Ser Val Xaa Lys  Glu Ser Ser 
    1070                 1075                 1080             


Leu Arg  Ala Xaa Gln Pro Ser  Glu Asn Asp Lys Leu  Gln Lys Glu 
    1085                 1090                 1095             


Leu Asn  Val Leu Lys Ser Glu  Gln Asn Asp Leu Arg  Leu Gln Met 
    1100                 1105                 1110             


Glu Ala  Gln Arg Ile Cys Leu  Ser Leu Val Tyr Ser  Xaa His Val 
    1115                 1120                 1125             


Asp Gln  Val Arg Glu Tyr Met  Glu Asn Glu Lys Asp  Lys Ala Leu 
    1130                 1135                 1140             


Cys Ser  Leu Lys Glu Glu Leu  Ile Phe Ala Gln Glu  Glu Lys Ile 
    1145                 1150                 1155             


Lys Glu  Leu Gln Lys Ile His  Gln Leu Glu Leu Gln  Xaa Met Lys 
    1160                 1165                 1170             


Xaa Gln  Glu Xaa Gly Asp Glu  Gly Lys Pro Leu His  Leu Leu Ile 
    1175                 1180                 1185             


Gly Lys  Leu Gln Lys Ala Val  Ser Glu Glu Cys Ser  Tyr Phe Leu 
    1190                 1195                 1200             


Gln Xaa  Leu Cys Ser Val Leu  Gly Glu Tyr Tyr Xaa  Pro Ala Leu 
    1205                 1210                 1215             


Lys Cys  Glu Val Asn Ala Glu  Asp Lys Glu Asn Ser  Gly Asp Tyr 
    1220                 1225                 1230             


Ile Ser  Glu Asn Glu Asp Pro  Glu Leu Gln Asp Tyr  Arg Tyr Glu 
    1235                 1240                 1245             


Val Gln  Asp Phe Gln Glu Asn  Met His Xaa Leu Leu  Asn Lys Val 
    1250                 1255                 1260             


Xaa Glu  Glu Tyr Asn Lys Leu  Leu Val Leu Gln Xaa  Arg Leu Ser 
    1265                 1270                 1275             


Lys Ile  Trp Gly Gln Gln Xaa  Asp Gly Met Lys Leu  Glu Phe Gly 
    1280                 1285                 1290             


Glu Glu  Asn Leu Pro Lys Glu  Glu Xaa Glu Phe Leu  Ser Ile His 
    1295                 1300                 1305             


Ser Gln  Met Xaa Asn Leu Glu  Asp Ile Asp Val Asn  His Lys Ser 
    1310                 1315                 1320             


Lys Leu  Ser Ser Leu Gln Asp  Leu Glu Lys Xaa Lys  Leu Glu Glu 
    1325                 1330                 1335             


Gln Val  Gln Glu Leu Glu Ser  Leu Ile Ser Ser Leu  Gln Gln Gln 
    1340                 1345                 1350             


Leu Lys  Glu Xaa Glu Gln Asn  Tyr Glu Ala Glu Ile  His Cys Leu 
    1355                 1360                 1365             


Gln Lys  Arg Leu Gln Ala Val  Ser Glu Ser Xaa Val  Pro Pro Ser 
    1370                 1375                 1380             


Leu Pro  Val Asp Ser Val Val  Ile Xaa Glu Ser Asp  Ala Gln Arg 
    1385                 1390                 1395             


Xaa Met  Tyr Pro Gly Ser Cys  Val Lys Lys Asn Ile  Asp Gly Xaa 
    1400                 1405                 1410             


Ile Glu  Phe Ser Gly Glu Phe  Gly Val Lys Glu Glu  Xaa Asn Ile 
    1415                 1420                 1425             


Val Lys  Leu Leu Glu Lys Gln  Tyr Gln Glu Gln Leu  Glu Glu Glu 
    1430                 1435                 1440             


Val Ala  Lys Val Ile Val Ser  Met Ser Ile Ala Phe  Ala Gln Gln 
    1445                 1450                 1455             


Xaa Glu  Leu Ser Arg Ile Ser  Gly Gly Lys Glu Asn  Xaa Ala Ser 
    1460                 1465                 1470             


Ser Lys  Gln Ala His Ala Val  Cys Gln Gln Glu Gln  His Tyr Phe 
    1475                 1480                 1485             


Asn Glu  Met Lys Leu Ser Gln  Asp Gln Ile Gly Phe  Gln Xaa Phe 
    1490                 1495                 1500             


Glu Xaa  Val Asp Val Lys Phe  Lys Glu Glu Phe Lys  Pro Leu Ser 
    1505                 1510                 1515             


Lys Glu  Leu Gly Glu His Gly  Lys Glu Ile Leu Leu  Ser Asn Ser 
    1520                 1525                 1530             


Asp Pro  His Asp Ile Pro Glu  Ser Lys Asp Cys Val  Leu Xaa Ile 
    1535                 1540                 1545             


Ser Glu  Glu Met Phe Ser Lys  Asp Lys Xaa Phe Ile  Val Arg Gln 
    1550                 1555                 1560             


Ser Ile  His Asp Glu Ile Ser  Val Ser Ser Met Asp  Ala Ser Arg 
    1565                 1570                 1575             


Gln Leu  Met Leu Asn Glu Glu  Gln Leu Glu Asp Met  Arg Gln Glu 
    1580                 1585                 1590             


Leu Val  Arg Gln Tyr Gln Glu  His Gln Gln Ala Xaa  Glu Leu Leu 
    1595                 1600                 1605             


Arg Gln  Ala His Met Arg Gln  Met Glu Arg Gln Arg  Glu Asp Gln 
    1610                 1615                 1620             


Glu Gln  Leu Gln Glu Glu Ile  Lys Arg Leu Asn Arg  Gln Leu Ala 
    1625                 1630                 1635             


Gln Asn  Gly Asn Glu Asn Gln  Gly Glu Val Glu Glu  Gln Xaa Phe 
    1640                 1645                 1650             


Lys Glu  Lys Glu Leu Asp Arg  Lys Pro Glu Asp Val  Pro Pro Glu 
    1655                 1660                 1665             


Ile Leu  Ser Asn Glu Arg Tyr  Ala Leu Gln Lys Ala  Asn Asn Arg 
    1670                 1675                 1680             


Leu Leu  Lys Ile Leu Leu Glu  Val Val Lys Xaa Xaa  Ala Ala Val 
    1685                 1690                 1695             


Glu Glu  Xaa Ile Gly Arg His  Val Leu Gly Ile Leu  Asp Arg Ser 
    1700                 1705                 1710             


Ser Lys  Ser Gln Ser Ser Ala  Ser Leu Ile Trp Arg  Ser Glu Ala 
    1715                 1720                 1725             


Glu Ala  Ser Val Lys Ser Cys  Val His Glu Glu His  Xaa Arg Val 
    1730                 1735                 1740             


Xaa Asp  Glu Ser Ile Pro Ser  Tyr Ser Gly Ser Asp  Met Pro Arg 
    1745                 1750                 1755             


Asn Asp  Ile Asn Met Trp Ser  Lys Val Xaa Glu Glu  Gly Xaa Glu 
    1760                 1765                 1770             


Leu Ser  Gln Arg Leu Val Arg  Ser Gly Phe Ala Gly  Xaa Glu Ile 
    1775                 1780                 1785             


Asp Pro  Glu Asn Glu Glu Leu  Met Leu Asn Ile Ser  Ser Arg Leu 
    1790                 1795                 1800             


Gln Ala  Ala Val Glu Lys Leu  Leu Glu Ala Ile Ser  Glu Xaa Ser 
    1805                 1810                 1815             


Ser Gln  Leu Glu His Ala Lys  Val Xaa Gln Xaa Glu  Leu Met Arg 
    1820                 1825                 1830             


Glu Ser  Phe Arg Gln Lys Gln  Glu Ala Xaa Glu Ser  Leu Lys Cys 
    1835                 1840                 1845             


Gln Glu  Glu Leu Arg Glu Arg  Leu His Glu Glu Ser  Arg Ala Arg 
    1850                 1855                 1860             


Glu Gln  Leu Ala Val Glu Leu  Ser Lys Ala Glu Gly  Val Ile Asp 
    1865                 1870                 1875             


Gly Tyr  Ala Asp Glu Lys Xaa  Leu Phe Glu Arg Gln  Ile Gln Glu 
    1880                 1885                 1890             


Lys Xaa  Asp Ile Ile Asp Arg  Leu Glu Gln Glu Leu  Leu Cys Ala 
    1895                 1900                 1905             


Ser Asn  Arg Leu Gln Glu Leu  Glu Ala Glu Gln Gln  Gln Ile Gln 
    1910                 1915                 1920             


Glu Glu  Arg Glu Leu Leu Ser  Arg Gln Lys Glu Ala  Met Lys Ala 
    1925                 1930                 1935             


Glu Ala  Gly Pro Val Glu Gln  Gln Leu Leu Gln Glu  Xaa Glu Lys 
    1940                 1945                 1950             


Leu Met  Lys Glu Lys Leu Glu  Val Gln Cys Gln Ala  Glu Lys Val 
    1955                 1960                 1965             


Arg Asp  Asp Leu Gln Lys Gln  Val Lys Ala Leu Glu  Ile Asp Val 
    1970                 1975                 1980             


Glu Glu  Gln Val Ser Arg Phe  Ile Glu Leu Glu Gln  Glu Lys Asn 
    1985                 1990                 1995             


Xaa Glu  Leu Met Asp Leu Arg  Gln Gln Asn Gln Ala  Leu Glu Lys 
    2000                 2005                 2010             


Gln Leu  Glu Lys Met Arg Lys  Phe Leu Asp Glu Gln  Ala Ile Asp 
    2015                 2020                 2025             


Arg Glu  His Glu Arg Asp Val  Phe Gln Gln Glu Ile  Gln Lys Leu 
    2030                 2035                 2040             


Glu Gln  Gln Leu Lys Val Val  Pro Arg Phe Gln Pro  Ile Ser Glu 
    2045                 2050                 2055             


His Gln  Xaa Arg Glu Val Glu  Gln Leu Ala Asn His  Leu Lys Glu 
    2060                 2065                 2070             


Lys Xaa  Asp Lys Cys Ser Glu  Leu Leu Leu Ser Lys  Glu Gln Leu 
    2075                 2080                 2085             


Gln Arg  Asp Ile Gln Glu Arg  Asn Glu Glu Ile Glu  Lys Leu Glu 
    2090                 2095                 2100             


Phe Arg  Val Arg Glu Leu Glu  Gln Ala Leu Leu Val  Ser Ala Asp 
    2105                 2110                 2115             


Xaa Phe  Gln Lys Val Glu Asp  Arg Lys His Phe Gly  Ala Val Glu 
    2120                 2125                 2130             


Ala Lys  Pro Glu Leu Ser Leu  Glu Val Gln Leu Gln  Ala Glu Arg 
    2135                 2140                 2145             


Asp Ala  Ile Asp Arg Lys Glu  Lys Glu Ile Xaa Asn  Leu Glu Glu 
    2150                 2155                 2160             


Gln Leu  Glu Gln Phe Arg Glu  Glu Leu Glu Asn Lys  Asn Glu Glu 
    2165                 2170                 2175             


Val Gln  Gln Leu His Met Gln  Leu Glu Ile Gln Lys  Lys Glu Ser 
    2180                 2185                 2190             


Xaa Xaa  Arg Leu Gln Glu Leu  Glu Gln Glu Asn Lys  Leu Phe Lys 
    2195                 2200                 2205             


Asp Asp  Met Glu Lys Leu Gly  Leu Ala Ile Lys Glu  Ser Asp Ala 
    2210                 2215                 2220             


Met Ser  Xaa Gln Asp Gln His  Val Leu Phe Gly Lys  Phe Ala Gln 
    2225                 2230                 2235             


Ile Ile  Gln Glu Lys Glu Val  Glu Ile Asp Gln Leu  Asn Glu Gln 
    2240                 2245                 2250             


Val Xaa  Lys Leu Gln Gln Gln  Leu Lys Ile Xaa Xaa  Asp Asn Lys 
    2255                 2260                 2265             


Val Ile  Glu Glu Lys Asn Glu  Leu Ile Arg Asp Leu  Glu Xaa Gln 
    2270                 2275                 2280             


Ile Glu  Cys Leu Met Ser Asp  Gln Glu Cys Val Lys  Arg Asn Arg 
    2285                 2290                 2295             


Glu Glu  Glu Ile Glu Gln Leu  Asn Glu Val Ile Glu  Lys Leu Gln 
    2300                 2305                 2310             


Gln Glu  Leu Ala Asn Ile Gly  Gln Lys Xaa Ser Met  Asn Ala His 
    2315                 2320                 2325             


Ser Leu  Ser Glu Glu Ala Asp  Ser Leu Lys His Gln  Leu Asp Val 
    2330                 2335                 2340             


Val Ile  Ala Glu Lys Leu Ala  Leu Glu Gln Gln Val  Glu Xaa Ala 
    2345                 2350                 2355             


Asn Glu  Glu Met Xaa Phe Met  Lys Asn Val Leu Lys  Glu Xaa Asn 
    2360                 2365                 2370             


Phe Lys  Met Asn Gln Leu Xaa  Gln Glu Leu Phe Ser  Leu Lys Arg 
    2375                 2380                 2385             


Glu Arg  Glu Ser Val Glu Lys  Ile Gln Ser Ile Pro  Glu Asn Ser 
    2390                 2395                 2400             


Val Asn  Val Ala Ile Asp His  Leu Ser Lys Asp Lys  Pro Glu Leu 
    2405                 2410                 2415             


Glu Val  Val Leu Xaa Glu Asp  Ala Leu Lys Ser Leu  Glu Asn Gln 
    2420                 2425                 2430             


Xaa Tyr  Phe Lys Ser Phe Glu  Glu Asn Gly Lys Gly  Ser Ile Ile 
    2435                 2440                 2445             


Asn Leu  Glu Xaa Arg Leu Leu  Gln Leu Glu Ser Xaa  Val Ser Ala 
    2450                 2455                 2460             


Lys Asp  Leu Glu Leu Xaa Gln  Cys Tyr Lys Gln Ile  Lys Asp Met 
    2465                 2470                 2475             


Gln Glu  Gln Gly Gln Phe Glu  Xaa Glu Met Leu Gln  Lys Lys Ile 
    2480                 2485                 2490             


Val Asn  Leu Gln Lys Ile Val  Glu Glu Lys Val Ala  Ala Ala Leu 
    2495                 2500                 2505             


Val Ser  Gln Ile Gln Leu Glu  Ala Val Gln Glu Tyr  Ala Lys Phe 
    2510                 2515                 2520             


Cys Gln  Asp Asn Gln Xaa Ile  Ser Ser Glu Pro Glu  Arg Xaa Asn 
    2525                 2530                 2535             


Ile Gln  Asn Leu Asn Gln Leu  Arg Glu Asp Glu Leu  Gly Ser Asp 
    2540                 2545                 2550             


Ile Ser  Ala Leu Xaa Leu Arg  Ile Ser Glu Leu Glu  Ser Gln Val 
    2555                 2560                 2565             


Val Glu  Met His Xaa Ser Leu  Ile Leu Glu Lys Glu  Gln Val Glu 
    2570                 2575                 2580             


Ile Ala  Glu Lys Asn Val Leu  Glu Lys Glu Lys Lys  Leu Leu Glu 
    2585                 2590                 2595             


Leu Gln  Lys Leu Leu Glu Gly  Asn Glu Lys Lys Gln  Arg Glu Lys 
    2600                 2605                 2610             


Glu Lys  Lys Arg Ser Pro Gln  Asp Val Glu Val Leu  Lys Xaa Xaa 
    2615                 2620                 2625             


Xaa Glu  Leu Phe His Ser Asn  Glu Glu Ser Gly Phe  Phe Asn Glu 
    2630                 2635                 2640             


Leu Glu  Ala Leu Arg Ala Glu  Ser Val Ala Xaa Lys  Ala Glu Leu 
    2645                 2650                 2655             


Ala Ser  Tyr Lys Glu Lys Ala  Glu Lys Leu Gln Glu  Glu Leu Leu 
    2660                 2665                 2670             


Val Lys  Glu Xaa Asn Met Xaa  Ser Leu Gln Lys Asp  Leu Ser Gln 
    2675                 2680                 2685             


Val Arg  Asp His Leu Ala Glu  Ala Lys Glu Lys Leu  Ser Ile Leu 
    2690                 2695                 2700             


Glu Lys  Glu Asp Glu Xaa Glu  Val Gln Glu Ser Lys  Lys Ala Cys 
    2705                 2710                 2715             


Met Phe  Glu Pro Leu Pro Ile  Lys Leu Ser Lys Ser  Ile Ala Ser 
    2720                 2725                 2730             


Gln Xaa  Asp Gly Xaa Leu Lys  Ile Ser Ser Ser Asn  Gln Xaa Pro 
    2735                 2740                 2745             


Gln Ile  Leu Val Lys Asn Ala  Gly Ile Gln Ile Asn  Leu Gln Ser 
    2750                 2755                 2760             


Glu Cys  Ser Ser Glu Glu Val  Xaa Glu Ile Ile Ser  Gln Phe Xaa 
    2765                 2770                 2775             


Glu Lys  Ile Glu Lys Met Gln  Glu Leu His Ala Ala  Glu Ile Leu 
    2780                 2785                 2790             


Asp Met  Glu Ser Arg His Ile  Ser Glu Xaa Glu Xaa  Leu Lys Arg 
    2795                 2800                 2805             


Glu His  Tyr Val Ala Val Gln  Leu Leu Lys Glu Glu  Cys Gly Xaa 
    2810                 2815                 2820             


Leu Lys  Ala Val Ile Gln Cys  Leu Arg Ser Lys Glu  Gly Ser Ser 
    2825                 2830                 2835             


Ile Pro  Glu Leu Ala His Ser  Asp Ala Tyr Gln Xaa  Arg Glu Ile 
    2840                 2845                 2850             


Cys Ser  Ser Asp Ser Gly Ser  Asp Trp Gly Gln Gly  Ile Tyr Leu 
    2855                 2860                 2865             


Xaa His  Ser Gln Gly Phe Asp  Ile Ala Ser Glu Gly  Arg Gly Glu 
    2870                 2875                 2880             


Glu Ser  Glu Ser Ala Xaa Asp  Ser Phe Pro Lys Lys  Ile Lys Gly 
    2885                 2890                 2895             


Leu Leu  Arg Ala Val His Asn  Glu Gly Met Gln Val  Leu Ser Leu 
    2900                 2905                 2910             


Xaa Glu  Ser Pro Tyr Ser Asp  Gly Glu Asp His Ser  Ile Gln Gln 
    2915                 2920                 2925             


Val Ser  Glu Pro Trp Leu Glu  Glu Arg Lys Ala Tyr  Ile Asn Xaa 
    2930                 2935                 2940             


Ile Ser  Ser Leu Lys Asp Leu  Ile Xaa Lys Met Gln  Leu Gln Arg 
    2945                 2950                 2955             


Glu Ala  Glu Val Tyr Asp Ser  Ser Gln Ser His Glu  Ser Phe Ser 
    2960                 2965                 2970             


Asp Trp  Arg Gly Glu Leu Leu  Leu Ala Leu Gln Gln  Val Phe Leu 
    2975                 2980                 2985             


Glu Glu  Arg Ser Val Leu Leu  Ala Ala Phe Arg Xaa  Glu Leu Xaa 
    2990                 2995                 3000             


Ala Leu  Gly Xaa Xaa Asp Ala  Val Gly Leu Leu Asn  Cys Leu Glu 
    3005                 3010                 3015             


Gln Arg  Ile Gln Glu Gln Gly  Val Glu Tyr Gln Ala  Ala Met Glu 
    3020                 3025                 3030             


Cys Leu  Gln Lys Ala Asp Arg  Arg Ser Leu Leu Ser  Glu Ile Gln 
    3035                 3040                 3045             


Ala Leu  His Ala Gln Met Asn  Gly Arg Lys Ile Xaa  Leu Lys Arg 
    3050                 3055                 3060             


Glu Gln  Glu Ser Glu Lys Pro  Ser Gln Gly Met Leu  Tyr Asp Lys 
    3065                 3070                 3075             


Leu Ile  Trp Leu His Lys Gln  Val Lys Arg Phe His  Phe Val Phe 
    3080                 3085                 3090             


Phe Leu  Ile Ile Ile Lys Leu  Lys His Ile Phe Leu  Val Xaa Phe 
    3095                 3100                 3105             


Ser Ser  His Ser His Asn Val  Lys Asp Xaa Ile Tyr  Ile Asn Tyr 
    3110                 3115                 3120             


Ser Arg  Gly 
    3125     


<210> 2132
<211> 3907
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1357)..(1357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1379)..(1379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1392)..(1392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1399)..(1399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1413)..(1413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1426)..(1426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1459)..(1459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1471)..(1471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1502)..(1502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1505)..(1505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1558)..(1558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1605)..(1605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1683)..(1683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1685)..(1685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1699)..(1699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1741)..(1742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1748)..(1748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1788)..(1788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1791)..(1791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1815)..(1815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1819)..(1819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1833)..(1833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1864)..(1864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1874)..(1874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1876)..(1876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1890)..(1890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1932)..(1932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1942)..(1942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1998)..(1998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2046)..(2046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2108)..(2108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2122)..(2122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2166)..(2166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2206)..(2206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2241)..(2242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2273)..(2273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2302)..(2302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2311)..(2312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2329)..(2329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2370)..(2370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2404)..(2404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2410)..(2410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2419)..(2419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2427)..(2427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2470)..(2470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2481)..(2481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2499)..(2499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2507)..(2507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2516)..(2516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2533)..(2533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2576)..(2576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2584)..(2584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2605)..(2605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2620)..(2620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2674)..(2676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2701)..(2701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2724)..(2724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2727)..(2727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2756)..(2756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2782)..(2782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2785)..(2785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2794)..(2794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2818)..(2818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2825)..(2825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2850)..(2850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2852)..(2852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2870)..(2870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2897)..(2897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2916)..(2916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2936)..(2936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2961)..(2961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2990)..(2990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2999)..(2999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3047)..(3047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3050)..(3050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3054)..(3055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3107)..(3107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3148)..(3148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3171)..(3171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3177)..(3178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3200)..(3200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3209)..(3209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3315)..(3315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3332)..(3332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3366)..(3366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3376)..(3376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3390)..(3390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3393)..(3393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3399)..(3399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3468)..(3469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3473)..(3473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3477)..(3477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3490)..(3490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3506)..(3506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3541)..(3541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3565)..(3565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3579)..(3579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3585)..(3585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3596)..(3596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3603)..(3603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3626)..(3626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3661)..(3661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3688)..(3688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3697)..(3697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3736)..(3736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3750)..(3750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3756)..(3756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3763)..(3763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3789)..(3789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3810)..(3810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3829)..(3830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3853)..(3853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3877)..(3877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3881)..(3881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3892)..(3892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3898)..(3899)
<223> Selenocysteine

<400> 2132
Met Glu Asp Glu Glu Arg Gln Lys Lys Leu Glu Ala Gly Lys Ala Lys 
1               5                   10                  15      


Leu Ala Gln Phe Arg Gln Arg Lys Ala Gln Ser Asp Gly Gln Ser Pro 
            20                  25                  30          


Ser Lys Lys Gln Lys Lys Lys Arg Lys Xaa Ser Ser Ser Lys His Asp 
        35                  40                  45              


Val Ser Ala His His Asp Leu Asn Ile Asp Gln Ser Gln Cys Asn Glu 
    50                  55                  60                  


Met Tyr Ile Asn Ser Ser Gln Arg Val Glu Ser Xaa Val Ile Pro Glu 
65                  70                  75                  80  


Ser Xaa Ile Met Arg Xaa Leu His Ser Gly Glu Ile Xaa Ser His Glu 
                85                  90                  95      


Gln Gly Phe Ser Val Glu Leu Glu Ser Glu Ile Ser Xaa Xaa Ala Asp 
            100                 105                 110         


Asp Cys Ser Ser Glu Val Asn Gly Cys Ser Phe Val Met Arg Xaa Gly 
        115                 120                 125             


Lys Pro Xaa Asn Leu Leu Arg Glu Glu Glu Phe Gly Val Asp Asp Ser 
    130                 135                 140                 


Tyr Ser Glu Gln Gly Ala Gln Asp Ser Pro Xaa His Leu Glu Met Met 
145                 150                 155                 160 


Glu Ser Glu Leu Ala Gly Lys Gln His Glu Ile Glu Glu Leu Asn Arg 
                165                 170                 175     


Glu Leu Glu Glu Met Arg Val Xaa Tyr Gly Xaa Glu Gly Leu Gln Gln 
            180                 185                 190         


Leu Gln Glu Phe Glu Ala Ala Ile Lys Gln Arg Asp Gly Ile Ile Xaa 
        195                 200                 205             


Gln Leu Xaa Ala Asn Leu Gln Gln Ala Arg Arg Glu Lys Asp Glu Xaa 
    210                 215                 220                 


Met Arg Glu Phe Leu Glu Leu Xaa Glu Gln Ser Gln Lys Leu Gln Ile 
225                 230                 235                 240 


Gln Phe Gln Gln Leu Gln Ala Ser Glu Xaa Leu Arg Asn Ser Xaa His 
                245                 250                 255     


Ser Ser Xaa Ala Ala Asp Leu Leu Gln Ala Lys Gln Gln Ile Leu Xaa 
            260                 265                 270         


His Gln Gln Gln Leu Glu Glu Gln Asp His Leu Leu Glu Asp Tyr Gln 
        275                 280                 285             


Lys Lys Lys Glu Asp Phe Xaa Met Gln Ile Ser Phe Leu Gln Glu Lys 
    290                 295                 300                 


Ile Lys Val Tyr Glu Met Glu Gln Asp Lys Lys Val Glu Asn Ser Asn 
305                 310                 315                 320 


Lys Glu Glu Ile Gln Glu Lys Glu Xaa Ile Ile Glu Glu Leu Asn Xaa 
                325                 330                 335     


Lys Ile Ile Glu Glu Glu Lys Lys Xaa Leu Glu Leu Lys Asp Lys Leu 
            340                 345                 350         


Xaa Xaa Ala Asp Lys Leu Leu Gly Glu Leu Gln Glu Gln Ile Val Gln 
        355                 360                 365             


Lys Asn Gln Glu Ile Lys Asn Met Lys Leu Glu Leu Xaa Asn Ser Lys 
    370                 375                 380                 


Gln Lys Glu Arg Gln Ser Ser Glu Glu Ile Lys Gln Leu Met Gly Xaa 
385                 390                 395                 400 


Val Glu Glu Leu Gln Lys Arg Asn His Lys Asp Ser Gln Phe Glu Xaa 
                405                 410                 415     


Asp Ile Val Gln Arg Met Glu Gln Glu Xaa Gln Arg Lys Leu Glu Gln 
            420                 425                 430         


Leu Arg Ala Glu Leu Asp Glu Met Tyr Gly Gln Gln Ile Val Gln Met 
        435                 440                 445             


Lys Gln Glu Leu Ile Arg Gln His Met Ala Gln Met Glu Glu Met Lys 
    450                 455                 460                 


Xaa Arg His Lys Gly Glu Met Glu Asn Ala Leu Arg Ser Tyr Ser Asn 
465                 470                 475                 480 


Ile Xaa Val Asn Glu Asp Gln Ile Lys Leu Met Asn Val Ala Ile Asn 
                485                 490                 495     


Glu Leu Asn Ile Lys Leu Gln Asp Xaa Asn Ser Gln Lys Glu Lys Leu 
            500                 505                 510         


Lys Glu Glu Leu Gly Leu Ile Leu Glu Glu Lys Cys Ala Leu Gln Arg 
        515                 520                 525             


Gln Leu Glu Asp Leu Val Glu Glu Leu Ser Phe Ser Arg Glu Gln Ile 
    530                 535                 540                 


Gln Arg Ala Arg Gln Xaa Ile Ala Glu Gln Glu Ser Lys Leu Asn Glu 
545                 550                 555                 560 


Ala His Lys Ser Leu Ser Xaa Val Glu Asp Leu Lys Ala Glu Ile Val 
                565                 570                 575     


Ser Ala Ser Glu Ser Arg Lys Glu Leu Glu Leu Lys His Glu Ala Glu 
            580                 585                 590         


Val Xaa Asn Tyr Lys Ile Lys Leu Glu Met Leu Glu Lys Glu Lys Asn 
        595                 600                 605             


Ala Val Leu Asp Arg Met Ala Glu Ser Gln Glu Ala Glu Leu Glu Arg 
    610                 615                 620                 


Leu Arg Xaa Gln Leu Leu Phe Ser His Glu Glu Glu Leu Ser Lys Leu 
625                 630                 635                 640 


Lys Glu Asp Leu Glu Ile Glu His Arg Ile Asn Ile Glu Lys Leu Lys 
                645                 650                 655     


Asp Asn Leu Gly Ile His Tyr Lys Gln Gln Ile Asp Gly Leu Gln Asn 
            660                 665                 670         


Glu Met Ser Gln Lys Ile Glu Xaa Met Gln Phe Glu Lys Asp Asn Leu 
        675                 680                 685             


Ile Xaa Lys Gln Asn Gln Leu Ile Leu Glu Ile Ser Lys Leu Lys Asp 
    690                 695                 700                 


Leu Gln Gln Ser Leu Val Asn Ser Lys Ser Glu Glu Met Xaa Leu Gln 
705                 710                 715                 720 


Ile Asn Glu Leu Gln Lys Glu Ile Glu Ile Leu Arg Gln Glu Glu Lys 
                725                 730                 735     


Glu Lys Gly Xaa Leu Glu Gln Glu Val Gln Glu Leu Gln Leu Lys Xaa 
            740                 745                 750         


Glu Leu Leu Glu Lys Gln Met Lys Glu Lys Glu Asn Asp Leu Gln Glu 
        755                 760                 765             


Lys Phe Ala Gln Leu Glu Ala Glu Asn Ser Ile Leu Lys Asp Glu Lys 
    770                 775                 780                 


Lys Xaa Leu Glu Asp Met Leu Lys Ile His Xaa Pro Val Ser Gln Glu 
785                 790                 795                 800 


Glu Arg Leu Ile Phe Leu Asp Ser Ile Lys Ser Lys Ser Lys Asp Ser 
                805                 810                 815     


Val Trp Glu Lys Glu Ile Glu Ile Leu Ile Glu Glu Asn Glu Asp Leu 
            820                 825                 830         


Lys Gln Gln Cys Ile Gln Leu Asn Glu Glu Ile Glu Lys Gln Arg Asn 
        835                 840                 845             


Xaa Phe Ser Phe Ala Glu Lys Asn Phe Glu Val Asn Tyr Gln Glu Leu 
    850                 855                 860                 


Gln Glu Glu Tyr Ala Cys Leu Leu Lys Val Lys Asp Asp Leu Glu Asp 
865                 870                 875                 880 


Ser Lys Asn Lys Gln Glu Leu Glu Tyr Lys Ser Lys Leu Lys Ala Leu 
                885                 890                 895     


Asn Glu Glu Leu His Leu Gln Arg Ile Asn Pro Xaa Xaa Val Lys Met 
            900                 905                 910         


Lys Ser Ser Val Phe Asp Glu Asp Lys Xaa Phe Val Ala Glu Xaa Leu 
        915                 920                 925             


Glu Met Gly Glu Val Val Glu Lys Asp Xaa Xaa Glu Leu Met Glu Lys 
    930                 935                 940                 


Leu Glu Val Xaa Lys Arg Glu Lys Leu Glu Leu Ser Gln Arg Leu Ser 
945                 950                 955                 960 


Asp Leu Ser Glu Gln Leu Lys Gln Lys His Gly Glu Ile Ser Phe Leu 
                965                 970                 975     


Asn Glu Glu Val Lys Ser Leu Lys Gln Glu Lys Glu Gln Val Ser Leu 
            980                 985                 990         


Arg Cys Arg Glu Leu Glu Ile Ile  Ile Asn His Asn Arg  Ala Glu Asn 
        995                 1000                 1005             


Val Gln  Ser Cys Asp Xaa Gln  Val Ser Ser Leu Leu  Asp Gly Val 
    1010                 1015                 1020             


Val Xaa  Met Xaa Ser Arg Gly  Ala Glu Gly Ser Val  Ser Lys Val 
    1025                 1030                 1035             


Asn Lys  Ser Phe Gly Glu Glu  Ser Lys Ile Met Val  Glu Asp Lys 
    1040                 1045                 1050             


Val Ser  Phe Glu Asn Met Xaa  Val Gly Glu Glu Ser  Lys Gln Glu 
    1055                 1060                 1065             


Gln Leu  Ile Leu Asp His Leu  Pro Ser Val Xaa Lys  Glu Ser Ser 
    1070                 1075                 1080             


Leu Arg  Ala Xaa Gln Pro Ser  Glu Asn Asp Lys Leu  Gln Lys Glu 
    1085                 1090                 1095             


Leu Asn  Val Leu Lys Ser Glu  Gln Asn Asp Leu Arg  Leu Gln Met 
    1100                 1105                 1110             


Glu Ala  Gln Arg Ile Cys Leu  Ser Leu Val Tyr Ser  Xaa His Val 
    1115                 1120                 1125             


Asp Gln  Val Arg Glu Tyr Met  Glu Asn Glu Lys Asp  Lys Ala Leu 
    1130                 1135                 1140             


Cys Ser  Leu Lys Glu Glu Leu  Ile Phe Ala Gln Glu  Glu Lys Ile 
    1145                 1150                 1155             


Lys Glu  Leu Gln Lys Ile His  Gln Leu Glu Leu Gln  Xaa Met Lys 
    1160                 1165                 1170             


Xaa Gln  Glu Xaa Gly Asp Glu  Gly Lys Pro Leu His  Leu Leu Ile 
    1175                 1180                 1185             


Gly Lys  Leu Gln Lys Ala Val  Ser Glu Glu Cys Ser  Tyr Phe Leu 
    1190                 1195                 1200             


Gln Xaa  Leu Cys Ser Val Leu  Gly Glu Tyr Tyr Xaa  Pro Ala Leu 
    1205                 1210                 1215             


Lys Cys  Glu Val Asn Ala Glu  Asp Lys Glu Asn Ser  Gly Asp Tyr 
    1220                 1225                 1230             


Ile Ser  Glu Asn Glu Asp Pro  Glu Leu Gln Asp Tyr  Arg Tyr Glu 
    1235                 1240                 1245             


Val Gln  Asp Phe Gln Glu Asn  Met His Xaa Leu Leu  Asn Lys Val 
    1250                 1255                 1260             


Xaa Glu  Glu Tyr Asn Lys Leu  Leu Val Leu Gln Xaa  Arg Leu Ser 
    1265                 1270                 1275             


Lys Ile  Trp Gly Gln Gln Xaa  Asp Gly Met Lys Leu  Glu Phe Gly 
    1280                 1285                 1290             


Glu Glu  Asn Leu Pro Lys Glu  Glu Xaa Glu Phe Leu  Ser Ile His 
    1295                 1300                 1305             


Ser Gln  Met Xaa Asn Leu Glu  Asp Ile Asp Val Asn  His Lys Ser 
    1310                 1315                 1320             


Lys Leu  Ser Ser Leu Gln Asp  Leu Glu Lys Xaa Lys  Leu Glu Glu 
    1325                 1330                 1335             


Gln Val  Gln Glu Leu Glu Ser  Leu Ile Ser Ser Leu  Gln Gln Gln 
    1340                 1345                 1350             


Leu Lys  Glu Xaa Glu Gln Asn  Tyr Glu Ala Glu Ile  His Cys Leu 
    1355                 1360                 1365             


Gln Lys  Arg Leu Gln Ala Val  Ser Glu Ser Xaa Val  Pro Pro Ser 
    1370                 1375                 1380             


Leu Pro  Val Asp Ser Val Val  Ile Xaa Glu Ser Asp  Ala Gln Arg 
    1385                 1390                 1395             


Xaa Met  Tyr Pro Gly Ser Cys  Val Lys Lys Asn Ile  Asp Gly Xaa 
    1400                 1405                 1410             


Ile Glu  Phe Ser Gly Glu Phe  Gly Val Lys Glu Glu  Xaa Asn Ile 
    1415                 1420                 1425             


Val Lys  Leu Leu Glu Lys Gln  Tyr Gln Glu Gln Leu  Glu Glu Glu 
    1430                 1435                 1440             


Val Ala  Lys Val Ile Val Ser  Met Ser Ile Ala Phe  Ala Gln Gln 
    1445                 1450                 1455             


Xaa Glu  Leu Ser Arg Ile Ser  Gly Gly Lys Glu Asn  Xaa Ala Ser 
    1460                 1465                 1470             


Ser Lys  Gln Ala His Ala Val  Cys Gln Gln Glu Gln  His Tyr Phe 
    1475                 1480                 1485             


Asn Glu  Met Lys Leu Ser Gln  Asp Gln Ile Gly Phe  Gln Xaa Phe 
    1490                 1495                 1500             


Glu Xaa  Val Asp Val Lys Phe  Lys Glu Glu Phe Lys  Pro Leu Ser 
    1505                 1510                 1515             


Lys Glu  Leu Gly Glu His Gly  Lys Glu Ile Leu Leu  Ser Asn Ser 
    1520                 1525                 1530             


Asp Pro  His Asp Ile Pro Glu  Ser Lys Asp Cys Val  Leu Xaa Ile 
    1535                 1540                 1545             


Ser Glu  Glu Met Phe Ser Lys  Asp Lys Xaa Phe Ile  Val Arg Gln 
    1550                 1555                 1560             


Ser Ile  His Asp Glu Ile Ser  Val Ser Ser Met Asp  Ala Ser Arg 
    1565                 1570                 1575             


Gln Leu  Met Leu Asn Glu Glu  Gln Leu Glu Asp Met  Arg Gln Glu 
    1580                 1585                 1590             


Leu Val  Arg Gln Tyr Gln Glu  His Gln Gln Ala Xaa  Glu Leu Leu 
    1595                 1600                 1605             


Arg Gln  Ala His Met Arg Gln  Met Glu Arg Gln Arg  Glu Asp Gln 
    1610                 1615                 1620             


Glu Gln  Leu Gln Glu Glu Ile  Lys Arg Leu Asn Arg  Gln Leu Ala 
    1625                 1630                 1635             


Gln Arg  Ser Ser Ile Asp Asn  Glu Asn Leu Val Ser  Glu Arg Glu 
    1640                 1645                 1650             


Arg Val  Leu Leu Glu Glu Leu  Glu Ala Leu Lys Gln  Leu Ser Leu 
    1655                 1660                 1665             


Ala Gly  Arg Glu Lys Leu Cys  Cys Glu Leu Arg Asn  Ser Ser Xaa 
    1670                 1675                 1680             


Gln Xaa  Gln Asn Gly Asn Glu  Asn Gln Gly Glu Val  Glu Glu Gln 
    1685                 1690                 1695             


Xaa Phe  Lys Glu Lys Glu Leu  Asp Arg Lys Pro Glu  Asp Val Pro 
    1700                 1705                 1710             


Pro Glu  Ile Leu Ser Asn Glu  Arg Tyr Ala Leu Gln  Lys Ala Asn 
    1715                 1720                 1725             


Asn Arg  Leu Leu Lys Ile Leu  Leu Glu Val Val Lys  Xaa Xaa Ala 
    1730                 1735                 1740             


Ala Val  Glu Glu Xaa Ile Gly  Arg His Val Leu Gly  Ile Leu Asp 
    1745                 1750                 1755             


Arg Ser  Ser Lys Ser Gln Ser  Ser Ala Ser Leu Ile  Trp Arg Ser 
    1760                 1765                 1770             


Glu Ala  Glu Ala Ser Val Lys  Ser Cys Val His Glu  Glu His Xaa 
    1775                 1780                 1785             


Arg Val  Xaa Asp Glu Ser Ile  Pro Ser Tyr Ser Gly  Ser Asp Met 
    1790                 1795                 1800             


Pro Arg  Asn Asp Ile Asn Met  Trp Ser Lys Val Xaa  Glu Glu Gly 
    1805                 1810                 1815             


Xaa Glu  Leu Ser Gln Arg Leu  Val Arg Ser Gly Phe  Ala Gly Xaa 
    1820                 1825                 1830             


Glu Ile  Asp Pro Glu Asn Glu  Glu Leu Met Leu Asn  Ile Ser Ser 
    1835                 1840                 1845             


Arg Leu  Gln Ala Ala Val Glu  Lys Leu Leu Glu Ala  Ile Ser Glu 
    1850                 1855                 1860             


Xaa Ser  Ser Gln Leu Glu His  Ala Lys Val Xaa Gln  Xaa Glu Leu 
    1865                 1870                 1875             


Met Arg  Glu Ser Phe Arg Gln  Lys Gln Glu Ala Xaa  Glu Ser Leu 
    1880                 1885                 1890             


Lys Cys  Gln Glu Glu Leu Arg  Glu Arg Leu His Glu  Glu Ser Arg 
    1895                 1900                 1905             


Ala Arg  Glu Gln Leu Ala Val  Glu Leu Ser Lys Ala  Glu Gly Val 
    1910                 1915                 1920             


Ile Asp  Gly Tyr Ala Asp Glu  Lys Xaa Leu Phe Glu  Arg Gln Ile 
    1925                 1930                 1935             


Gln Glu  Lys Xaa Asp Ile Ile  Asp Arg Leu Glu Gln  Glu Leu Leu 
    1940                 1945                 1950             


Cys Ala  Ser Asn Arg Leu Gln  Glu Leu Glu Ala Glu  Gln Gln Gln 
    1955                 1960                 1965             


Ile Gln  Glu Glu Arg Glu Leu  Leu Ser Arg Gln Lys  Glu Ala Met 
    1970                 1975                 1980             


Lys Ala  Glu Ala Gly Pro Val  Glu Gln Gln Leu Leu  Gln Glu Xaa 
    1985                 1990                 1995             


Glu Lys  Leu Met Lys Glu Lys  Leu Glu Val Gln Cys  Gln Ala Glu 
    2000                 2005                 2010             


Lys Val  Arg Asp Asp Leu Gln  Lys Gln Val Lys Ala  Leu Glu Ile 
    2015                 2020                 2025             


Asp Val  Glu Glu Gln Val Ser  Arg Phe Ile Glu Leu  Glu Gln Glu 
    2030                 2035                 2040             


Lys Asn  Xaa Glu Leu Met Asp  Leu Arg Gln Gln Asn  Gln Ala Leu 
    2045                 2050                 2055             


Glu Lys  Gln Leu Glu Lys Met  Arg Lys Phe Leu Asp  Glu Gln Ala 
    2060                 2065                 2070             


Ile Asp  Arg Glu His Glu Arg  Asp Val Phe Gln Gln  Glu Ile Gln 
    2075                 2080                 2085             


Lys Leu  Glu Gln Gln Leu Lys  Val Val Pro Arg Phe  Gln Pro Ile 
    2090                 2095                 2100             


Ser Glu  His Gln Xaa Arg Glu  Val Glu Gln Leu Ala  Asn His Leu 
    2105                 2110                 2115             


Lys Glu  Lys Xaa Asp Lys Cys  Ser Glu Leu Leu Leu  Ser Lys Glu 
    2120                 2125                 2130             


Gln Leu  Gln Arg Asp Ile Gln  Glu Arg Asn Glu Glu  Ile Glu Lys 
    2135                 2140                 2145             


Leu Glu  Phe Arg Val Arg Glu  Leu Glu Gln Ala Leu  Leu Val Ser 
    2150                 2155                 2160             


Ala Asp  Xaa Phe Gln Lys Val  Glu Asp Arg Lys His  Phe Gly Ala 
    2165                 2170                 2175             


Val Glu  Ala Lys Pro Glu Leu  Ser Leu Glu Val Gln  Leu Gln Ala 
    2180                 2185                 2190             


Glu Arg  Asp Ala Ile Asp Arg  Lys Glu Lys Glu Ile  Xaa Asn Leu 
    2195                 2200                 2205             


Glu Glu  Gln Leu Glu Gln Phe  Arg Glu Glu Leu Glu  Asn Lys Asn 
    2210                 2215                 2220             


Glu Glu  Val Gln Gln Leu His  Met Gln Leu Glu Ile  Gln Lys Lys 
    2225                 2230                 2235             


Glu Ser  Xaa Xaa Arg Leu Gln  Glu Leu Glu Gln Glu  Asn Lys Leu 
    2240                 2245                 2250             


Phe Lys  Asp Asp Met Glu Lys  Leu Gly Leu Ala Ile  Lys Glu Ser 
    2255                 2260                 2265             


Asp Ala  Met Ser Xaa Gln Asp  Gln His Val Leu Phe  Gly Lys Phe 
    2270                 2275                 2280             


Ala Gln  Ile Ile Gln Glu Lys  Glu Val Glu Ile Asp  Gln Leu Asn 
    2285                 2290                 2295             


Glu Gln  Val Xaa Lys Leu Gln  Gln Gln Leu Lys Ile  Xaa Xaa Asp 
    2300                 2305                 2310             


Asn Lys  Val Ile Glu Glu Lys  Asn Glu Leu Ile Arg  Asp Leu Glu 
    2315                 2320                 2325             


Xaa Gln  Ile Glu Cys Leu Met  Ser Asp Gln Glu Cys  Val Lys Arg 
    2330                 2335                 2340             


Asn Arg  Glu Glu Glu Ile Glu  Gln Leu Asn Glu Val  Ile Glu Lys 
    2345                 2350                 2355             


Leu Gln  Gln Glu Leu Ala Asn  Ile Gly Gln Lys Xaa  Ser Met Asn 
    2360                 2365                 2370             


Ala His  Ser Leu Ser Glu Glu  Ala Asp Ser Leu Lys  His Gln Leu 
    2375                 2380                 2385             


Asp Val  Val Ile Ala Glu Lys  Leu Ala Leu Glu Gln  Gln Val Glu 
    2390                 2395                 2400             


Xaa Ala  Asn Glu Glu Met Xaa  Phe Met Lys Asn Val  Leu Lys Glu 
    2405                 2410                 2415             


Xaa Asn  Phe Lys Met Asn Gln  Leu Xaa Gln Glu Leu  Phe Ser Leu 
    2420                 2425                 2430             


Lys Arg  Glu Arg Glu Ser Val  Glu Lys Ile Gln Ser  Ile Pro Glu 
    2435                 2440                 2445             


Asn Ser  Val Asn Val Ala Ile  Asp His Leu Ser Lys  Asp Lys Pro 
    2450                 2455                 2460             


Glu Leu  Glu Val Val Leu Xaa  Glu Asp Ala Leu Lys  Ser Leu Glu 
    2465                 2470                 2475             


Asn Gln  Xaa Tyr Phe Lys Ser  Phe Glu Glu Asn Gly  Lys Gly Ser 
    2480                 2485                 2490             


Ile Ile  Asn Leu Glu Xaa Arg  Leu Leu Gln Leu Glu  Ser Xaa Val 
    2495                 2500                 2505             


Ser Ala  Lys Asp Leu Glu Leu  Xaa Gln Cys Tyr Lys  Gln Ile Lys 
    2510                 2515                 2520             


Asp Met  Gln Glu Gln Gly Gln  Phe Glu Xaa Glu Met  Leu Gln Lys 
    2525                 2530                 2535             


Lys Ile  Val Asn Leu Gln Lys  Ile Val Glu Glu Lys  Val Ala Ala 
    2540                 2545                 2550             


Ala Leu  Val Ser Gln Ile Gln  Leu Glu Ala Val Gln  Glu Tyr Ala 
    2555                 2560                 2565             


Lys Phe  Cys Gln Asp Asn Gln  Xaa Ile Ser Ser Glu  Pro Glu Arg 
    2570                 2575                 2580             


Xaa Asn  Ile Gln Asn Leu Asn  Gln Leu Arg Glu Asp  Glu Leu Gly 
    2585                 2590                 2595             


Ser Asp  Ile Ser Ala Leu Xaa  Leu Arg Ile Ser Glu  Leu Glu Ser 
    2600                 2605                 2610             


Gln Val  Val Glu Met His Xaa  Ser Leu Ile Leu Glu  Lys Glu Gln 
    2615                 2620                 2625             


Val Glu  Ile Ala Glu Lys Asn  Val Leu Glu Lys Glu  Lys Lys Leu 
    2630                 2635                 2640             


Leu Glu  Leu Gln Lys Leu Leu  Glu Gly Asn Glu Lys  Lys Gln Arg 
    2645                 2650                 2655             


Glu Lys  Glu Lys Lys Arg Ser  Pro Gln Asp Val Glu  Val Leu Lys 
    2660                 2665                 2670             


Xaa Xaa  Xaa Glu Leu Phe His  Ser Asn Glu Glu Ser  Gly Phe Phe 
    2675                 2680                 2685             


Asn Glu  Leu Glu Ala Leu Arg  Ala Glu Ser Val Ala  Xaa Lys Ala 
    2690                 2695                 2700             


Glu Leu  Ala Ser Tyr Lys Glu  Lys Ala Glu Lys Leu  Gln Glu Glu 
    2705                 2710                 2715             


Leu Leu  Val Lys Glu Xaa Asn  Met Xaa Ser Leu Gln  Lys Asp Leu 
    2720                 2725                 2730             


Ser Gln  Val Arg Asp His Leu  Ala Glu Ala Lys Glu  Lys Leu Ser 
    2735                 2740                 2745             


Ile Leu  Glu Lys Glu Asp Glu  Xaa Glu Val Gln Glu  Ser Lys Lys 
    2750                 2755                 2760             


Ala Cys  Met Phe Glu Pro Leu  Pro Ile Lys Leu Ser  Lys Ser Ile 
    2765                 2770                 2775             


Ala Ser  Gln Xaa Asp Gly Xaa  Leu Lys Ile Ser Ser  Ser Asn Gln 
    2780                 2785                 2790             


Xaa Pro  Gln Ile Leu Val Lys  Asn Ala Gly Ile Gln  Ile Asn Leu 
    2795                 2800                 2805             


Gln Ser  Glu Cys Ser Ser Glu  Glu Val Xaa Glu Ile  Ile Ser Gln 
    2810                 2815                 2820             


Phe Xaa  Glu Lys Ile Glu Lys  Met Gln Glu Leu His  Ala Ala Glu 
    2825                 2830                 2835             


Ile Leu  Asp Met Glu Ser Arg  His Ile Ser Glu Xaa  Glu Xaa Leu 
    2840                 2845                 2850             


Lys Arg  Glu His Tyr Val Ala  Val Gln Leu Leu Lys  Glu Glu Cys 
    2855                 2860                 2865             


Gly Xaa  Leu Lys Ala Val Ile  Gln Cys Leu Arg Ser  Lys Glu Gly 
    2870                 2875                 2880             


Ser Ser  Ile Pro Glu Leu Ala  His Ser Asp Ala Tyr  Gln Xaa Arg 
    2885                 2890                 2895             


Glu Ile  Cys Ser Ser Asp Ser  Gly Ser Asp Trp Gly  Gln Gly Ile 
    2900                 2905                 2910             


Tyr Leu  Xaa His Ser Gln Gly  Phe Asp Ile Ala Ser  Glu Gly Arg 
    2915                 2920                 2925             


Gly Glu  Glu Ser Glu Ser Ala  Xaa Asp Ser Phe Pro  Lys Lys Ile 
    2930                 2935                 2940             


Lys Gly  Leu Leu Arg Ala Val  His Asn Glu Gly Met  Gln Val Leu 
    2945                 2950                 2955             


Ser Leu  Xaa Glu Ser Pro Tyr  Ser Asp Gly Glu Asp  His Ser Ile 
    2960                 2965                 2970             


Gln Gln  Val Ser Glu Pro Trp  Leu Glu Glu Arg Lys  Ala Tyr Ile 
    2975                 2980                 2985             


Asn Xaa  Ile Ser Ser Leu Lys  Asp Leu Ile Xaa Lys  Met Gln Leu 
    2990                 2995                 3000             


Gln Arg  Glu Ala Glu Val Tyr  Asp Ser Ser Gln Ser  His Glu Ser 
    3005                 3010                 3015             


Phe Ser  Asp Trp Arg Gly Glu  Leu Leu Leu Ala Leu  Gln Gln Val 
    3020                 3025                 3030             


Phe Leu  Glu Glu Arg Ser Val  Leu Leu Ala Ala Phe  Arg Xaa Glu 
    3035                 3040                 3045             


Leu Xaa  Ala Leu Gly Xaa Xaa  Asp Ala Val Gly Leu  Leu Asn Cys 
    3050                 3055                 3060             


Leu Glu  Gln Arg Ile Gln Glu  Gln Gly Val Glu Tyr  Gln Ala Ala 
    3065                 3070                 3075             


Met Glu  Cys Leu Gln Lys Ala  Asp Arg Arg Ser Leu  Leu Ser Glu 
    3080                 3085                 3090             


Ile Gln  Ala Leu His Ala Gln  Met Asn Gly Arg Lys  Ile Xaa Leu 
    3095                 3100                 3105             


Lys Arg  Glu Gln Glu Ser Glu  Lys Pro Ser Gln Glu  Leu Leu Glu 
    3110                 3115                 3120             


Tyr Asn  Ile Gln Gln Lys Gln  Ser Gln Met Leu Glu  Met Gln Val 
    3125                 3130                 3135             


Glu Leu  Ser Ser Met Lys Asp  Arg Ala Xaa Glu Leu  Gln Glu Gln 
    3140                 3145                 3150             


Leu Ser  Ser Glu Lys Met Val  Val Ala Glu Leu Lys  Ser Glu Leu 
    3155                 3160                 3165             


Ala Gln  Xaa Lys Leu Glu Leu  Glu Xaa Xaa Leu Lys  Ala Gln His 
    3170                 3175                 3180             


Lys His  Leu Lys Glu Leu Glu  Ala Phe Arg Leu Glu  Val Lys Asp 
    3185                 3190                 3195             


Lys Xaa  Asp Glu Val His Leu  Leu Asn Asp Xaa Leu  Ala Ser Glu 
    3200                 3205                 3210             


Gln Lys  Lys Ser Arg Glu Leu  Gln Trp Ala Leu Glu  Lys Glu Lys 
    3215                 3220                 3225             


Ala Lys  Leu Gly Arg Ser Glu  Glu Arg Asp Lys Glu  Glu Leu Glu 
    3230                 3235                 3240             


Asp Leu  Lys Phe Ser Leu Glu  Ser Gln Lys Gln Arg  Asn Leu Gln 
    3245                 3250                 3255             


Leu Asn  Leu Leu Leu Glu Gln  Gln Lys Gln Leu Leu  Asn Glu Ser 
    3260                 3265                 3270             


Gln Gln  Lys Ile Glu Ser Gln  Arg Met Leu Tyr Asp  Ala Gln Leu 
    3275                 3280                 3285             


Ser Glu  Glu Gln Gly Arg Asn  Leu Glu Leu Gln Val  Leu Leu Glu 
    3290                 3295                 3300             


Ser Glu  Lys Val Arg Ile Arg  Glu Met Ser Ser Xaa  Leu Asp Arg 
    3305                 3310                 3315             


Glu Arg  Glu Leu His Ala Gln  Leu Gln Ser Ser Asp  Gly Xaa Gly 
    3320                 3325                 3330             


Gln Ser  Arg Pro Pro Leu Pro  Ser Glu Asp Leu Leu  Lys Glu Leu 
    3335                 3340                 3345             


Gln Lys  Gln Leu Glu Glu Lys  His Ser Arg Ile Val  Glu Leu Leu 
    3350                 3355                 3360             


Asn Glu  Xaa Glu Lys Tyr Lys  Leu Asp Ser Leu Gln  Xaa Arg Gln 
    3365                 3370                 3375             


Gln Met  Glu Lys Asp Arg Gln  Val His Arg Lys Xaa  Leu Gln Xaa 
    3380                 3385                 3390             


Glu Gln  Glu Ala Asn Xaa Glu  Gly Gln Lys Lys Met  His Glu Leu 
    3395                 3400                 3405             


Gln Ser  Lys Val Glu Asp Leu  Gln Arg Gln Leu Glu  Glu Lys Arg 
    3410                 3415                 3420             


Gln Gln  Val Tyr Lys Leu Asp  Leu Glu Gly Gln Arg  Leu Gln Gly 
    3425                 3430                 3435             


Ile Met  Gln Glu Phe Gln Lys  Gln Glu Leu Glu Arg  Glu Glu Lys 
    3440                 3445                 3450             


Arg Glu  Ser Arg Arg Ile Leu  Tyr Gln Asn Leu Asn  Glu Pro Xaa 
    3455                 3460                 3465             


Xaa Trp  Ser Leu Xaa Ser Asp  Arg Xaa Arg Asn Trp  Val Leu Gln 
    3470                 3475                 3480             


Gln Lys  Ile Glu Gly Glu Xaa  Lys Glu Ser Asn Tyr  Ala Lys Leu 
    3485                 3490                 3495             


Ile Glu  Met Asn Gly Gly Gly  Xaa Gly Cys Asn His  Glu Leu Glu 
    3500                 3505                 3510             


Met Ile  Arg Gln Lys Leu Gln  Cys Val Ala Ser Lys  Leu Gln Val 
    3515                 3520                 3525             


Leu Pro  Gln Lys Ala Ser Glu  Arg Leu Gln Phe Glu  Xaa Ala Asp 
    3530                 3535                 3540             


Asp Glu  Asp Phe Ile Trp Val  Gln Glu Asn Ile Asp  Glu Ile Ile 
    3545                 3550                 3555             


Leu Gln  Leu Gln Lys Leu Xaa  Gly Gln Gln Gly Glu  Glu Pro Ser 
    3560                 3565                 3570             


Leu Val  Ser Pro Ser Xaa Ser  Cys Gly Ser Leu Xaa  Glu Arg Leu 
    3575                 3580                 3585             


Leu Arg  Gln Asn Ala Glu Leu  Xaa Gly His Ile Ser  Gln Leu Xaa 
    3590                 3595                 3600             


Glu Glu  Lys Asn Asp Leu Arg  Asn Met Val Met Lys  Leu Glu Glu 
    3605                 3610                 3615             


Gln Ile  Arg Trp Tyr Arg Gln  Xaa Gly Ala Gly Arg  Asp Asn Ser 
    3620                 3625                 3630             


Ser Arg  Phe Ser Leu Asn Gly  Gly Ala Asn Ile Glu  Ala Ile Ile 
    3635                 3640                 3645             


Ala Ser  Glu Lys Glu Val Trp  Asn Arg Glu Lys Leu  Xaa Leu Gln 
    3650                 3655                 3660             


Lys Ser  Leu Lys Arg Ala Glu  Ala Glu Val Tyr Lys  Leu Lys Ala 
    3665                 3670                 3675             


Glu Leu  Arg Asn Asp Ser Leu  Leu Gln Xaa Leu Ser  Pro Asp Ser 
    3680                 3685                 3690             


Glu His  Val Xaa Leu Lys Arg  Ile Tyr Gly Lys Tyr  Leu Arg Ala 
    3695                 3700                 3705             


Glu Ser  Phe Arg Lys Ala Leu  Ile Tyr Gln Lys Lys  Tyr Leu Leu 
    3710                 3715                 3720             


Leu Leu  Leu Gly Gly Phe Gln  Glu Cys Glu Asp Ala  Xaa Leu Ala 
    3725                 3730                 3735             


Leu Leu  Ala Arg Met Gly Gly  Gln Pro Ala Phe Xaa  Asp Leu Glu 
    3740                 3745                 3750             


Val Ile  Xaa Asn Arg Pro Lys  Gly Phe Xaa Arg Phe  Arg Ser Ala 
    3755                 3760                 3765             


Val Arg  Val Ser Ile Ala Ile  Ser Arg Met Lys Phe  Leu Val Arg 
    3770                 3775                 3780             


Arg Trp  His Arg Val Xaa Gly  Ser Val Ser Ile Asn  Ile Asn Arg 
    3785                 3790                 3795             


Asp Gly  Phe Gly Leu Asn Gln  Gly Ala Glu Lys Xaa  Asp Ser Phe 
    3800                 3805                 3810             


Tyr His  Ser Ser Gly Gly Leu  Glu Leu Tyr Gly Glu  Pro Arg His 
    3815                 3820                 3825             


Xaa Xaa  Tyr Arg Ser Arg Ser  Asp Leu Asp Tyr Ile  Arg Ser Pro 
    3830                 3835                 3840             


Leu Pro  Phe Gln Asn Arg Tyr  Pro Gly Xaa Pro Ala  Asp Phe Asn 
    3845                 3850                 3855             


Pro Gly  Ser Leu Ala Cys Ser  Gln Leu Gln Asn Tyr  Asp Pro Asp 
    3860                 3865                 3870             


Arg Ala  Leu Xaa Asp Tyr Ile  Xaa Arg Leu Glu Ala  Leu Gln Arg 
    3875                 3880                 3885             


Arg Leu  Gly Xaa Ile Gln Ser  Gly Ser Xaa Xaa Gln  Phe His Ala 
    3890                 3895                 3900             


Gly Met  Arg Arg 
    3905         


<210> 2133
<211> 1637
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1179)..(1179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1213)..(1213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1272)..(1272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1293)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1320)..(1320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1342)..(1342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1365)..(1365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1387)..(1387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1400)..(1400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1421)..(1421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1467)..(1467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1479)..(1479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1510)..(1510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1566)..(1566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1613)..(1613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1634)..(1634)
<223> Selenocysteine

<400> 2133
Met Glu Asp Glu Glu Arg Gln Lys Lys Leu Glu Ala Gly Lys Ala Lys 
1               5                   10                  15      


Val Gly Glu Leu Ile Phe Phe Phe Leu Ala Gln Phe Arg Gln Arg Lys 
            20                  25                  30          


Ala Gln Ser Asp Gly Gln Ser Pro Ser Lys Lys Gln Lys Lys Lys Arg 
        35                  40                  45              


Lys Xaa Ser Ser Ser Lys His Asp Val Ser Ala His His Asp Leu Asn 
    50                  55                  60                  


Ile Asp Gln Ser Gln Cys Asn Glu Met Tyr Ile Asn Ser Ser Gln Arg 
65                  70                  75                  80  


Val Glu Ser Xaa Val Ile Pro Glu Ser Xaa Ile Met Arg Xaa Leu His 
                85                  90                  95      


Ser Gly Glu Ile Xaa Ser His Glu Gln Gly Phe Ser Val Glu Leu Glu 
            100                 105                 110         


Ser Glu Ile Ser Xaa Xaa Ala Asp Asp Cys Ser Ser Glu Val Asn Gly 
        115                 120                 125             


Cys Ser Phe Val Met Arg Xaa Gly Lys Pro Xaa Asn Leu Leu Arg Glu 
    130                 135                 140                 


Glu Glu Phe Gly Val Asp Asp Ser Tyr Ser Glu Gln Gly Ala Gln Asp 
145                 150                 155                 160 


Ser Pro Xaa His Leu Glu Met Met Glu Ser Glu Leu Ala Gly Lys Gln 
                165                 170                 175     


His Glu Ile Glu Glu Leu Asn Arg Glu Leu Glu Glu Met Arg Val Xaa 
            180                 185                 190         


Tyr Gly Xaa Glu Gly Leu Gln Gln Leu Gln Glu Phe Glu Ala Ala Ile 
        195                 200                 205             


Lys Gln Arg Asp Gly Ile Ile Xaa Gln Leu Xaa Ala Asn Leu Gln Gln 
    210                 215                 220                 


Ala Arg Arg Glu Lys Asp Glu Xaa Met Arg Glu Phe Leu Glu Leu Xaa 
225                 230                 235                 240 


Glu Gln Ser Gln Lys Leu Gln Ile Gln Phe Gln Gln Leu Gln Ala Ser 
                245                 250                 255     


Glu Xaa Leu Arg Asn Ser Xaa His Ser Ser Xaa Ala Ala Asp Leu Leu 
            260                 265                 270         


Gln Ala Lys Gln Gln Ile Leu Xaa His Gln Gln Gln Leu Glu Glu Gln 
        275                 280                 285             


Asp His Leu Leu Glu Asp Tyr Gln Lys Lys Lys Glu Asp Phe Xaa Met 
    290                 295                 300                 


Gln Ile Ser Phe Leu Gln Glu Lys Ile Lys Val Tyr Glu Met Glu Gln 
305                 310                 315                 320 


Asp Lys Lys Val Glu Asn Ser Asn Lys Glu Glu Ile Gln Glu Lys Glu 
                325                 330                 335     


Xaa Ile Ile Glu Glu Leu Asn Xaa Lys Ile Ile Glu Glu Glu Lys Lys 
            340                 345                 350         


Xaa Leu Glu Leu Lys Asp Lys Leu Xaa Xaa Ala Asp Lys Leu Leu Gly 
        355                 360                 365             


Glu Leu Gln Glu Gln Ile Val Gln Lys Asn Gln Glu Ile Lys Asn Met 
    370                 375                 380                 


Lys Leu Glu Leu Xaa Asn Ser Lys Gln Lys Glu Arg Gln Ser Ser Glu 
385                 390                 395                 400 


Glu Ile Lys Gln Leu Met Gly Xaa Val Glu Glu Leu Gln Lys Arg Asn 
                405                 410                 415     


His Lys Asp Ser Gln Phe Glu Xaa Asp Ile Val Gln Arg Met Glu Gln 
            420                 425                 430         


Glu Xaa Gln Arg Lys Leu Glu Gln Leu Arg Ala Glu Leu Asp Glu Met 
        435                 440                 445             


Tyr Gly Gln Gln Ile Val Gln Met Lys Gln Glu Leu Ile Arg Gln His 
    450                 455                 460                 


Met Ala Gln Met Glu Glu Met Lys Xaa Arg His Lys Gly Glu Met Glu 
465                 470                 475                 480 


Asn Ala Leu Arg Ser Tyr Ser Asn Ile Xaa Val Asn Glu Asp Gln Ile 
                485                 490                 495     


Lys Leu Met Asn Val Ala Ile Asn Glu Leu Asn Ile Lys Leu Gln Asp 
            500                 505                 510         


Xaa Asn Ser Gln Lys Glu Lys Leu Lys Glu Glu Leu Gly Leu Ile Leu 
        515                 520                 525             


Glu Glu Lys Cys Ala Leu Gln Arg Gln Leu Glu Asp Leu Val Glu Glu 
    530                 535                 540                 


Leu Ser Phe Ser Arg Glu Gln Ile Gln Arg Ala Arg Gln Xaa Ile Ala 
545                 550                 555                 560 


Glu Gln Glu Ser Lys Leu Asn Glu Ala His Lys Ser Leu Ser Xaa Val 
                565                 570                 575     


Glu Asp Leu Lys Ala Glu Ile Val Ser Ala Ser Glu Ser Arg Lys Glu 
            580                 585                 590         


Leu Glu Leu Lys His Glu Ala Glu Val Xaa Asn Tyr Lys Ile Lys Leu 
        595                 600                 605             


Glu Met Leu Glu Lys Glu Lys Asn Ala Val Leu Asp Arg Met Ala Glu 
    610                 615                 620                 


Ser Gln Glu Ala Glu Leu Glu Arg Leu Arg Xaa Gln Leu Leu Phe Ser 
625                 630                 635                 640 


His Glu Glu Glu Leu Ser Lys Leu Lys Glu Asp Leu Glu Ile Glu His 
                645                 650                 655     


Arg Ile Asn Ile Glu Lys Leu Lys Asp Asn Leu Gly Ile His Tyr Lys 
            660                 665                 670         


Gln Gln Ile Asp Gly Leu Gln Asn Glu Met Ser Gln Lys Ile Glu Xaa 
        675                 680                 685             


Met Gln Phe Glu Lys Asp Asn Leu Ile Xaa Lys Gln Asn Gln Leu Ile 
    690                 695                 700                 


Leu Glu Ile Ser Lys Leu Lys Asp Leu Gln Gln Ser Leu Val Asn Ser 
705                 710                 715                 720 


Lys Ser Glu Glu Met Xaa Leu Gln Ile Asn Glu Leu Gln Lys Glu Ile 
                725                 730                 735     


Glu Ile Leu Arg Gln Glu Glu Lys Glu Lys Gly Xaa Leu Glu Gln Glu 
            740                 745                 750         


Val Gln Glu Leu Gln Leu Lys Xaa Glu Leu Leu Glu Lys Gln Met Lys 
        755                 760                 765             


Glu Lys Glu Asn Asp Leu Gln Glu Lys Phe Ala Gln Leu Glu Ala Glu 
    770                 775                 780                 


Asn Ser Ile Leu Lys Asp Glu Lys Lys Xaa Leu Glu Asp Met Leu Lys 
785                 790                 795                 800 


Ile His Xaa Pro Val Ser Gln Glu Glu Arg Leu Ile Phe Leu Asp Ser 
                805                 810                 815     


Ile Lys Ser Lys Ser Lys Asp Ser Val Trp Glu Lys Glu Ile Glu Ile 
            820                 825                 830         


Leu Ile Glu Glu Asn Glu Asp Leu Lys Gln Gln Cys Ile Gln Leu Asn 
        835                 840                 845             


Glu Glu Ile Glu Lys Gln Arg Asn Xaa Phe Ser Phe Ala Glu Lys Asn 
    850                 855                 860                 


Phe Glu Val Asn Tyr Gln Glu Leu Gln Glu Glu Tyr Ala Cys Leu Leu 
865                 870                 875                 880 


Lys Val Lys Asp Asp Leu Glu Asp Ser Lys Asn Lys Gln Glu Leu Glu 
                885                 890                 895     


Tyr Lys Ser Lys Leu Lys Ala Leu Asn Glu Glu Leu His Leu Gln Arg 
            900                 905                 910         


Ile Asn Pro Xaa Xaa Val Lys Met Lys Ser Ser Val Phe Asp Glu Asp 
        915                 920                 925             


Lys Xaa Phe Val Ala Glu Xaa Leu Glu Met Gly Glu Val Val Glu Lys 
    930                 935                 940                 


Asp Xaa Xaa Glu Leu Met Glu Lys Leu Glu Val Xaa Lys Arg Glu Lys 
945                 950                 955                 960 


Leu Glu Leu Ser Gln Arg Leu Ser Asp Leu Ser Glu Gln Leu Lys Gln 
                965                 970                 975     


Lys His Gly Glu Ile Ser Phe Leu Asn Glu Glu Val Lys Ser Leu Lys 
            980                 985                 990         


Gln Glu Lys Glu Gln Val Ser Leu  Arg Cys Arg Glu Leu  Glu Ile Ile 
        995                 1000                 1005             


Ile Asn  His Asn Arg Ala Glu  Asn Val Gln Ser Cys  Asp Xaa Gln 
    1010                 1015                 1020             


Val Ser  Ser Leu Leu Asp Gly  Val Val Xaa Met Xaa  Ser Arg Gly 
    1025                 1030                 1035             


Ala Glu  Gly Ser Val Ser Lys  Val Asn Lys Ser Phe  Gly Glu Glu 
    1040                 1045                 1050             


Ser Lys  Ile Met Val Glu Asp  Lys Val Ser Phe Glu  Asn Met Xaa 
    1055                 1060                 1065             


Val Gly  Glu Glu Ser Lys Gln  Glu Gln Leu Ile Leu  Asp His Leu 
    1070                 1075                 1080             


Pro Ser  Val Xaa Lys Glu Ser  Ser Leu Arg Ala Xaa  Gln Pro Ser 
    1085                 1090                 1095             


Glu Asn  Asp Lys Leu Gln Lys  Glu Leu Asn Val Leu  Lys Ser Glu 
    1100                 1105                 1110             


Gln Asn  Asp Leu Arg Leu Gln  Met Glu Ala Gln Arg  Ile Cys Leu 
    1115                 1120                 1125             


Ser Leu  Val Tyr Ser Xaa His  Val Asp Gln Val Arg  Glu Tyr Met 
    1130                 1135                 1140             


Glu Asn  Glu Lys Asp Lys Ala  Leu Cys Ser Leu Lys  Glu Glu Leu 
    1145                 1150                 1155             


Ile Phe  Ala Gln Glu Glu Lys  Ile Lys Glu Leu Gln  Lys Ile His 
    1160                 1165                 1170             


Gln Leu  Glu Leu Gln Xaa Met  Lys Xaa Gln Glu Xaa  Gly Asp Glu 
    1175                 1180                 1185             


Gly Lys  Pro Leu His Leu Leu  Ile Gly Lys Leu Gln  Lys Ala Val 
    1190                 1195                 1200             


Ser Glu  Glu Cys Ser Tyr Phe  Leu Gln Xaa Leu Cys  Ser Val Leu 
    1205                 1210                 1215             


Gly Glu  Tyr Tyr Xaa Pro Ala  Leu Lys Cys Glu Val  Asn Ala Glu 
    1220                 1225                 1230             


Asp Lys  Glu Asn Ser Gly Asp  Tyr Ile Ser Glu Asn  Glu Asp Pro 
    1235                 1240                 1245             


Glu Leu  Gln Asp Tyr Arg Tyr  Glu Val Gln Asp Phe  Gln Glu Asn 
    1250                 1255                 1260             


Met His  Xaa Leu Leu Asn Lys  Val Xaa Glu Glu Tyr  Asn Lys Leu 
    1265                 1270                 1275             


Leu Val  Leu Gln Xaa Arg Leu  Ser Lys Ile Trp Gly  Gln Gln Xaa 
    1280                 1285                 1290             


Asp Gly  Met Lys Leu Glu Phe  Gly Glu Glu Asn Leu  Pro Lys Glu 
    1295                 1300                 1305             


Glu Xaa  Glu Phe Leu Ser Ile  His Ser Gln Met Xaa  Asn Leu Glu 
    1310                 1315                 1320             


Asp Ile  Asp Val Asn His Lys  Ser Lys Leu Ser Ser  Leu Gln Asp 
    1325                 1330                 1335             


Leu Glu  Lys Xaa Lys Leu Glu  Glu Gln Val Gln Glu  Leu Glu Ser 
    1340                 1345                 1350             


Leu Ile  Ser Ser Leu Gln Gln  Gln Leu Lys Glu Xaa  Glu Gln Asn 
    1355                 1360                 1365             


Tyr Glu  Ala Glu Ile His Cys  Leu Gln Lys Arg Leu  Gln Ala Val 
    1370                 1375                 1380             


Ser Glu  Ser Xaa Val Pro Pro  Ser Leu Pro Val Asp  Ser Val Val 
    1385                 1390                 1395             


Ile Xaa  Glu Ser Asp Ala Gln  Arg Xaa Met Tyr Pro  Gly Ser Cys 
    1400                 1405                 1410             


Val Lys  Lys Asn Ile Asp Gly  Xaa Ile Glu Phe Ser  Gly Glu Phe 
    1415                 1420                 1425             


Gly Val  Lys Glu Glu Xaa Asn  Ile Val Lys Leu Leu  Glu Lys Gln 
    1430                 1435                 1440             


Tyr Gln  Glu Gln Leu Glu Glu  Glu Val Ala Lys Val  Ile Val Ser 
    1445                 1450                 1455             


Met Ser  Ile Ala Phe Ala Gln  Gln Xaa Glu Leu Ser  Arg Ile Ser 
    1460                 1465                 1470             


Gly Gly  Lys Glu Asn Xaa Ala  Ser Ser Lys Gln Ala  His Ala Val 
    1475                 1480                 1485             


Cys Gln  Gln Glu Gln His Tyr  Phe Asn Glu Met Lys  Leu Ser Gln 
    1490                 1495                 1500             


Asp Gln  Ile Gly Phe Gln Xaa  Phe Glu Xaa Val Asp  Val Lys Phe 
    1505                 1510                 1515             


Lys Glu  Glu Phe Lys Pro Leu  Ser Lys Glu Leu Gly  Glu His Gly 
    1520                 1525                 1530             


Lys Glu  Ile Leu Leu Ser Asn  Ser Asp Pro His Asp  Ile Pro Glu 
    1535                 1540                 1545             


Ser Lys  Asp Cys Val Leu Xaa  Ile Ser Glu Glu Met  Phe Ser Lys 
    1550                 1555                 1560             


Asp Lys  Xaa Phe Ile Val Arg  Gln Ser Ile His Asp  Glu Ile Ser 
    1565                 1570                 1575             


Val Ser  Ser Met Asp Ala Ser  Arg Gln Leu Met Leu  Asn Glu Glu 
    1580                 1585                 1590             


Gln Leu  Glu Asp Met Arg Gln  Glu Leu Val Arg Gln  Tyr Gln Glu 
    1595                 1600                 1605             


His Gln  Gln Ala Xaa Glu Leu  Leu Arg Gln Ala His  Met Arg Gln 
    1610                 1615                 1620             


Met Glu  Arg Gln Arg Glu Asp  Gln Glu Gln Xaa Arg  Arg Asp 
    1625                 1630                 1635         


<210> 2134
<211> 3910
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1071)..(1071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1226)..(1226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1296)..(1296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1313)..(1313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1323)..(1323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1368)..(1368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1403)..(1403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1410)..(1410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1424)..(1424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1437)..(1437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1470)..(1470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1482)..(1482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1516)..(1516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1558)..(1558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1569)..(1569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1616)..(1616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1694)..(1694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1696)..(1696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1710)..(1710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1752)..(1753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1759)..(1759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1799)..(1799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1802)..(1802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1826)..(1826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1830)..(1830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1844)..(1844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1875)..(1875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1885)..(1885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1887)..(1887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1901)..(1901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1943)..(1943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1953)..(1953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2009)..(2009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2057)..(2057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2119)..(2119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2133)..(2133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2177)..(2177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2217)..(2217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2252)..(2253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2284)..(2284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2313)..(2313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2322)..(2323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2340)..(2340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2381)..(2381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2415)..(2415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2421)..(2421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2430)..(2430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2438)..(2438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2481)..(2481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2492)..(2492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2510)..(2510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2518)..(2518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2527)..(2527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2544)..(2544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2587)..(2587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2595)..(2595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2616)..(2616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2631)..(2631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2685)..(2687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2712)..(2712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2735)..(2735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2738)..(2738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2767)..(2767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2793)..(2793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2796)..(2796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2805)..(2805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2829)..(2829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2836)..(2836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2861)..(2861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2863)..(2863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2881)..(2881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2904)..(2904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2919)..(2919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2939)..(2939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2964)..(2964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2993)..(2993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3002)..(3002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3050)..(3050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3053)..(3053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3057)..(3058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3110)..(3110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3151)..(3151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3174)..(3174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3180)..(3181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3203)..(3203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3212)..(3212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3318)..(3318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3335)..(3335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3369)..(3369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3379)..(3379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3393)..(3393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3396)..(3396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3402)..(3402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3471)..(3472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3476)..(3476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3480)..(3480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3493)..(3493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3509)..(3509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3544)..(3544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3568)..(3568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3582)..(3582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3588)..(3588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3599)..(3599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3606)..(3606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3629)..(3629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3664)..(3664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3691)..(3691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3700)..(3700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3739)..(3739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3753)..(3753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3759)..(3759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3766)..(3766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3792)..(3792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3813)..(3813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3832)..(3833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3856)..(3856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3880)..(3880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3884)..(3884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3895)..(3895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3901)..(3902)
<223> Selenocysteine

<400> 2134
Met Glu Asp Glu Glu Arg Gln Lys Lys Leu Glu Ala Gly Lys Ala Lys 
1               5                   10                  15      


Val Gly Glu Pro Glu Gly Tyr Phe Leu Phe Ser Leu Ala Gln Phe Arg 
            20                  25                  30          


Gln Arg Lys Ala Gln Ser Asp Gly Gln Ser Pro Ser Lys Lys Gln Lys 
        35                  40                  45              


Lys Lys Arg Lys Xaa Ser Ser Ser Lys His Asp Val Ser Ala His His 
    50                  55                  60                  


Asp Leu Asn Ile Asp Gln Ser Gln Cys Asn Glu Met Tyr Ile Asn Ser 
65                  70                  75                  80  


Ser Gln Arg Val Glu Ser Xaa Val Ile Pro Glu Ser Xaa Ile Met Arg 
                85                  90                  95      


Xaa Leu His Ser Gly Glu Ile Xaa Ser His Glu Gln Gly Phe Ser Val 
            100                 105                 110         


Glu Leu Glu Ser Glu Ile Ser Xaa Xaa Ala Asp Asp Cys Ser Ser Glu 
        115                 120                 125             


Val Asn Gly Cys Ser Phe Val Met Arg Xaa Gly Lys Pro Xaa Asn Leu 
    130                 135                 140                 


Leu Arg Glu Glu Glu Phe Gly Val Asp Asp Ser Tyr Ser Glu Gln Gly 
145                 150                 155                 160 


Ala Gln Asp Ser Pro Xaa His Leu Glu Met Met Glu Ser Glu Leu Ala 
                165                 170                 175     


Gly Lys Gln His Glu Ile Glu Glu Leu Asn Arg Glu Leu Glu Glu Met 
            180                 185                 190         


Arg Val Xaa Tyr Gly Xaa Glu Gly Leu Gln Gln Leu Gln Glu Phe Glu 
        195                 200                 205             


Ala Ala Ile Lys Gln Arg Asp Gly Ile Ile Xaa Gln Leu Xaa Ala Asn 
    210                 215                 220                 


Leu Gln Gln Ala Arg Arg Glu Lys Asp Glu Xaa Met Arg Glu Phe Leu 
225                 230                 235                 240 


Glu Leu Xaa Glu Gln Ser Gln Lys Leu Gln Ile Gln Phe Gln Gln Leu 
                245                 250                 255     


Gln Ala Ser Glu Xaa Leu Arg Asn Ser Xaa His Ser Ser Xaa Ala Ala 
            260                 265                 270         


Asp Leu Leu Gln Ala Lys Gln Gln Ile Leu Xaa His Gln Gln Gln Leu 
        275                 280                 285             


Glu Glu Gln Asp His Leu Leu Glu Asp Tyr Gln Lys Lys Lys Glu Asp 
    290                 295                 300                 


Phe Xaa Met Gln Ile Ser Phe Leu Gln Glu Lys Ile Lys Val Tyr Glu 
305                 310                 315                 320 


Met Glu Gln Asp Lys Lys Val Glu Asn Ser Asn Lys Glu Glu Ile Gln 
                325                 330                 335     


Glu Lys Glu Xaa Ile Ile Glu Glu Leu Asn Xaa Lys Ile Ile Glu Glu 
            340                 345                 350         


Glu Lys Lys Xaa Leu Glu Leu Lys Asp Lys Leu Xaa Xaa Ala Asp Lys 
        355                 360                 365             


Leu Leu Gly Glu Leu Gln Glu Gln Ile Val Gln Lys Asn Gln Glu Ile 
    370                 375                 380                 


Lys Asn Met Lys Leu Glu Leu Xaa Asn Ser Lys Gln Lys Glu Arg Gln 
385                 390                 395                 400 


Ser Ser Glu Glu Ile Lys Gln Leu Met Gly Xaa Val Glu Glu Leu Gln 
                405                 410                 415     


Lys Arg Asn His Lys Asp Ser Gln Phe Glu Xaa Asp Ile Val Gln Arg 
            420                 425                 430         


Met Glu Gln Glu Xaa Gln Arg Lys Leu Glu Gln Leu Arg Ala Glu Leu 
        435                 440                 445             


Asp Glu Met Tyr Gly Gln Gln Ile Val Gln Met Lys Gln Glu Leu Ile 
    450                 455                 460                 


Arg Gln His Met Ala Gln Met Glu Glu Met Lys Xaa Arg His Lys Gly 
465                 470                 475                 480 


Glu Met Glu Asn Ala Leu Arg Ser Tyr Ser Asn Ile Xaa Val Asn Glu 
                485                 490                 495     


Asp Gln Ile Lys Leu Met Asn Val Ala Ile Asn Glu Leu Asn Ile Lys 
            500                 505                 510         


Leu Gln Asp Xaa Asn Ser Gln Lys Glu Lys Leu Lys Glu Glu Leu Gly 
        515                 520                 525             


Leu Ile Leu Glu Glu Lys Cys Ala Leu Gln Arg Gln Leu Glu Asp Leu 
    530                 535                 540                 


Val Glu Glu Leu Ser Phe Ser Arg Glu Gln Ile Gln Arg Ala Arg Gln 
545                 550                 555                 560 


Xaa Ile Ala Glu Gln Glu Ser Lys Leu Asn Glu Ala His Lys Ser Leu 
                565                 570                 575     


Ser Xaa Val Glu Asp Leu Lys Ala Glu Ile Val Ser Ala Ser Glu Ser 
            580                 585                 590         


Arg Lys Glu Leu Glu Leu Lys His Glu Ala Glu Val Xaa Asn Tyr Lys 
        595                 600                 605             


Ile Lys Leu Glu Met Leu Glu Lys Glu Lys Asn Ala Val Leu Asp Arg 
    610                 615                 620                 


Met Ala Glu Ser Gln Glu Ala Glu Leu Glu Arg Leu Arg Xaa Gln Leu 
625                 630                 635                 640 


Leu Phe Ser His Glu Glu Glu Leu Ser Lys Leu Lys Glu Asp Leu Glu 
                645                 650                 655     


Ile Glu His Arg Ile Asn Ile Glu Lys Leu Lys Asp Asn Leu Gly Ile 
            660                 665                 670         


His Tyr Lys Gln Gln Ile Asp Gly Leu Gln Asn Glu Met Ser Gln Lys 
        675                 680                 685             


Ile Glu Xaa Met Gln Phe Glu Lys Asp Asn Leu Ile Xaa Lys Gln Asn 
    690                 695                 700                 


Gln Leu Ile Leu Glu Ile Ser Lys Leu Lys Asp Leu Gln Gln Ser Leu 
705                 710                 715                 720 


Val Asn Ser Lys Ser Glu Glu Met Xaa Leu Gln Ile Asn Glu Leu Gln 
                725                 730                 735     


Lys Glu Ile Glu Ile Leu Arg Gln Glu Glu Lys Glu Lys Gly Xaa Leu 
            740                 745                 750         


Glu Gln Glu Val Gln Glu Leu Gln Leu Lys Xaa Glu Leu Leu Glu Lys 
        755                 760                 765             


Gln Met Lys Glu Lys Glu Asn Asp Leu Gln Glu Lys Phe Ala Gln Leu 
    770                 775                 780                 


Glu Ala Glu Asn Ser Ile Leu Lys Asp Glu Lys Lys Xaa Leu Glu Asp 
785                 790                 795                 800 


Met Leu Lys Ile His Xaa Pro Val Ser Gln Glu Glu Arg Leu Ile Phe 
                805                 810                 815     


Leu Asp Ser Ile Lys Ser Lys Ser Lys Asp Ser Val Trp Glu Lys Glu 
            820                 825                 830         


Ile Glu Ile Leu Ile Glu Glu Asn Glu Asp Leu Lys Gln Gln Cys Ile 
        835                 840                 845             


Gln Leu Asn Glu Glu Ile Glu Lys Gln Arg Asn Xaa Phe Ser Phe Ala 
    850                 855                 860                 


Glu Lys Asn Phe Glu Val Asn Tyr Gln Glu Leu Gln Glu Glu Tyr Ala 
865                 870                 875                 880 


Cys Leu Leu Lys Val Lys Asp Asp Leu Glu Asp Ser Lys Asn Lys Gln 
                885                 890                 895     


Glu Leu Glu Tyr Lys Ser Lys Leu Lys Ala Leu Asn Glu Glu Leu His 
            900                 905                 910         


Leu Gln Arg Ile Asn Pro Xaa Xaa Val Lys Met Lys Ser Ser Val Phe 
        915                 920                 925             


Asp Glu Asp Lys Xaa Phe Val Ala Glu Xaa Leu Glu Met Gly Glu Val 
    930                 935                 940                 


Val Glu Lys Asp Xaa Xaa Glu Leu Met Glu Lys Leu Glu Val Xaa Lys 
945                 950                 955                 960 


Arg Glu Lys Leu Glu Leu Ser Gln Arg Leu Ser Asp Leu Ser Glu Gln 
                965                 970                 975     


Leu Lys Gln Lys His Gly Glu Ile Ser Phe Leu Asn Glu Glu Val Lys 
            980                 985                 990         


Ser Leu Lys Gln Glu Lys Glu Gln  Val Ser Leu Arg Cys  Arg Glu Leu 
        995                 1000                 1005             


Glu Ile  Ile Ile Asn His Asn  Arg Ala Glu Asn Val  Gln Ser Cys 
    1010                 1015                 1020             


Asp Xaa  Gln Val Ser Ser Leu  Leu Asp Gly Val Val  Xaa Met Xaa 
    1025                 1030                 1035             


Ser Arg  Gly Ala Glu Gly Ser  Val Ser Lys Val Asn  Lys Ser Phe 
    1040                 1045                 1050             


Gly Glu  Glu Ser Lys Ile Met  Val Glu Asp Lys Val  Ser Phe Glu 
    1055                 1060                 1065             


Asn Met  Xaa Val Gly Glu Glu  Ser Lys Gln Glu Gln  Leu Ile Leu 
    1070                 1075                 1080             


Asp His  Leu Pro Ser Val Xaa  Lys Glu Ser Ser Leu  Arg Ala Xaa 
    1085                 1090                 1095             


Gln Pro  Ser Glu Asn Asp Lys  Leu Gln Lys Glu Leu  Asn Val Leu 
    1100                 1105                 1110             


Lys Ser  Glu Gln Asn Asp Leu  Arg Leu Gln Met Glu  Ala Gln Arg 
    1115                 1120                 1125             


Ile Cys  Leu Ser Leu Val Tyr  Ser Xaa His Val Asp  Gln Val Arg 
    1130                 1135                 1140             


Glu Tyr  Met Glu Asn Glu Lys  Asp Lys Ala Leu Cys  Ser Leu Lys 
    1145                 1150                 1155             


Glu Glu  Leu Ile Phe Ala Gln  Glu Glu Lys Ile Lys  Glu Leu Gln 
    1160                 1165                 1170             


Lys Ile  His Gln Leu Glu Leu  Gln Xaa Met Lys Xaa  Gln Glu Xaa 
    1175                 1180                 1185             


Gly Asp  Glu Gly Lys Pro Leu  His Leu Leu Ile Gly  Lys Leu Gln 
    1190                 1195                 1200             


Lys Ala  Val Ser Glu Glu Cys  Ser Tyr Phe Leu Gln  Xaa Leu Cys 
    1205                 1210                 1215             


Ser Val  Leu Gly Glu Tyr Tyr  Xaa Pro Ala Leu Lys  Cys Glu Val 
    1220                 1225                 1230             


Asn Ala  Glu Asp Lys Glu Asn  Ser Gly Asp Tyr Ile  Ser Glu Asn 
    1235                 1240                 1245             


Glu Asp  Pro Glu Leu Gln Asp  Tyr Arg Tyr Glu Val  Gln Asp Phe 
    1250                 1255                 1260             


Gln Glu  Asn Met His Xaa Leu  Leu Asn Lys Val Xaa  Glu Glu Tyr 
    1265                 1270                 1275             


Asn Lys  Leu Leu Val Leu Gln  Xaa Arg Leu Ser Lys  Ile Trp Gly 
    1280                 1285                 1290             


Gln Gln  Xaa Asp Gly Met Lys  Leu Glu Phe Gly Glu  Glu Asn Leu 
    1295                 1300                 1305             


Pro Lys  Glu Glu Xaa Glu Phe  Leu Ser Ile His Ser  Gln Met Xaa 
    1310                 1315                 1320             


Asn Leu  Glu Asp Ile Asp Val  Asn His Lys Ser Lys  Leu Ser Ser 
    1325                 1330                 1335             


Leu Gln  Asp Leu Glu Lys Xaa  Lys Leu Glu Glu Gln  Val Gln Glu 
    1340                 1345                 1350             


Leu Glu  Ser Leu Ile Ser Ser  Leu Gln Gln Gln Leu  Lys Glu Xaa 
    1355                 1360                 1365             


Glu Gln  Asn Tyr Glu Ala Glu  Ile His Cys Leu Gln  Lys Arg Leu 
    1370                 1375                 1380             


Gln Ala  Val Ser Glu Ser Xaa  Val Pro Pro Ser Leu  Pro Val Asp 
    1385                 1390                 1395             


Ser Val  Val Ile Xaa Glu Ser  Asp Ala Gln Arg Xaa  Met Tyr Pro 
    1400                 1405                 1410             


Gly Ser  Cys Val Lys Lys Asn  Ile Asp Gly Xaa Ile  Glu Phe Ser 
    1415                 1420                 1425             


Gly Glu  Phe Gly Val Lys Glu  Glu Xaa Asn Ile Val  Lys Leu Leu 
    1430                 1435                 1440             


Glu Lys  Gln Tyr Gln Glu Gln  Leu Glu Glu Glu Val  Ala Lys Val 
    1445                 1450                 1455             


Ile Val  Ser Met Ser Ile Ala  Phe Ala Gln Gln Xaa  Glu Leu Ser 
    1460                 1465                 1470             


Arg Ile  Ser Gly Gly Lys Glu  Asn Xaa Ala Ser Ser  Lys Gln Ala 
    1475                 1480                 1485             


His Ala  Val Cys Gln Gln Glu  Gln His Tyr Phe Asn  Glu Met Lys 
    1490                 1495                 1500             


Leu Ser  Gln Asp Gln Ile Gly  Phe Gln Xaa Phe Glu  Xaa Val Asp 
    1505                 1510                 1515             


Val Lys  Phe Lys Glu Glu Phe  Lys Pro Leu Ser Lys  Glu Leu Gly 
    1520                 1525                 1530             


Glu His  Gly Lys Glu Ile Leu  Leu Ser Asn Ser Asp  Pro His Asp 
    1535                 1540                 1545             


Ile Pro  Glu Ser Lys Asp Cys  Val Leu Xaa Ile Ser  Glu Glu Met 
    1550                 1555                 1560             


Phe Ser  Lys Asp Lys Xaa Phe  Ile Val Arg Gln Ser  Ile His Asp 
    1565                 1570                 1575             


Glu Ile  Ser Val Ser Ser Met  Asp Ala Ser Arg Gln  Leu Met Leu 
    1580                 1585                 1590             


Asn Glu  Glu Gln Leu Glu Asp  Met Arg Gln Glu Leu  Val Arg Gln 
    1595                 1600                 1605             


Tyr Gln  Glu His Gln Gln Ala  Xaa Glu Leu Leu Arg  Gln Ala His 
    1610                 1615                 1620             


Met Arg  Gln Met Glu Arg Gln  Arg Glu Asp Gln Glu  Gln Leu Gln 
    1625                 1630                 1635             


Glu Glu  Ile Lys Arg Leu Asn  Arg Gln Leu Ala Gln  Arg Ser Ser 
    1640                 1645                 1650             


Ile Asp  Asn Glu Asn Leu Val  Ser Glu Arg Glu Arg  Val Leu Leu 
    1655                 1660                 1665             


Glu Glu  Leu Glu Ala Leu Lys  Gln Leu Ser Leu Ala  Gly Arg Glu 
    1670                 1675                 1680             


Lys Leu  Cys Cys Glu Leu Arg  Asn Ser Ser Xaa Gln  Xaa Gln Asn 
    1685                 1690                 1695             


Gly Asn  Glu Asn Gln Gly Glu  Val Glu Glu Gln Xaa  Phe Lys Glu 
    1700                 1705                 1710             


Lys Glu  Leu Asp Arg Lys Pro  Glu Asp Val Pro Pro  Glu Ile Leu 
    1715                 1720                 1725             


Ser Asn  Glu Arg Tyr Ala Leu  Gln Lys Ala Asn Asn  Arg Leu Leu 
    1730                 1735                 1740             


Lys Ile  Leu Leu Glu Val Val  Lys Xaa Xaa Ala Ala  Val Glu Glu 
    1745                 1750                 1755             


Xaa Ile  Gly Arg His Val Leu  Gly Ile Leu Asp Arg  Ser Ser Lys 
    1760                 1765                 1770             


Ser Gln  Ser Ser Ala Ser Leu  Ile Trp Arg Ser Glu  Ala Glu Ala 
    1775                 1780                 1785             


Ser Val  Lys Ser Cys Val His  Glu Glu His Xaa Arg  Val Xaa Asp 
    1790                 1795                 1800             


Glu Ser  Ile Pro Ser Tyr Ser  Gly Ser Asp Met Pro  Arg Asn Asp 
    1805                 1810                 1815             


Ile Asn  Met Trp Ser Lys Val  Xaa Glu Glu Gly Xaa  Glu Leu Ser 
    1820                 1825                 1830             


Gln Arg  Leu Val Arg Ser Gly  Phe Ala Gly Xaa Glu  Ile Asp Pro 
    1835                 1840                 1845             


Glu Asn  Glu Glu Leu Met Leu  Asn Ile Ser Ser Arg  Leu Gln Ala 
    1850                 1855                 1860             


Ala Val  Glu Lys Leu Leu Glu  Ala Ile Ser Glu Xaa  Ser Ser Gln 
    1865                 1870                 1875             


Leu Glu  His Ala Lys Val Xaa  Gln Xaa Glu Leu Met  Arg Glu Ser 
    1880                 1885                 1890             


Phe Arg  Gln Lys Gln Glu Ala  Xaa Glu Ser Leu Lys  Cys Gln Glu 
    1895                 1900                 1905             


Glu Leu  Arg Glu Arg Leu His  Glu Glu Ser Arg Ala  Arg Glu Gln 
    1910                 1915                 1920             


Leu Ala  Val Glu Leu Ser Lys  Ala Glu Gly Val Ile  Asp Gly Tyr 
    1925                 1930                 1935             


Ala Asp  Glu Lys Xaa Leu Phe  Glu Arg Gln Ile Gln  Glu Lys Xaa 
    1940                 1945                 1950             


Asp Ile  Ile Asp Arg Leu Glu  Gln Glu Leu Leu Cys  Ala Ser Asn 
    1955                 1960                 1965             


Arg Leu  Gln Glu Leu Glu Ala  Glu Gln Gln Gln Ile  Gln Glu Glu 
    1970                 1975                 1980             


Arg Glu  Leu Leu Ser Arg Gln  Lys Glu Ala Met Lys  Ala Glu Ala 
    1985                 1990                 1995             


Gly Pro  Val Glu Gln Gln Leu  Leu Gln Glu Xaa Glu  Lys Leu Met 
    2000                 2005                 2010             


Lys Glu  Lys Leu Glu Val Gln  Cys Gln Ala Glu Lys  Val Arg Asp 
    2015                 2020                 2025             


Asp Leu  Gln Lys Gln Val Lys  Ala Leu Glu Ile Asp  Val Glu Glu 
    2030                 2035                 2040             


Gln Val  Ser Arg Phe Ile Glu  Leu Glu Gln Glu Lys  Asn Xaa Glu 
    2045                 2050                 2055             


Leu Met  Asp Leu Arg Gln Gln  Asn Gln Ala Leu Glu  Lys Gln Leu 
    2060                 2065                 2070             


Glu Lys  Met Arg Lys Phe Leu  Asp Glu Gln Ala Ile  Asp Arg Glu 
    2075                 2080                 2085             


His Glu  Arg Asp Val Phe Gln  Gln Glu Ile Gln Lys  Leu Glu Gln 
    2090                 2095                 2100             


Gln Leu  Lys Val Val Pro Arg  Phe Gln Pro Ile Ser  Glu His Gln 
    2105                 2110                 2115             


Xaa Arg  Glu Val Glu Gln Leu  Ala Asn His Leu Lys  Glu Lys Xaa 
    2120                 2125                 2130             


Asp Lys  Cys Ser Glu Leu Leu  Leu Ser Lys Glu Gln  Leu Gln Arg 
    2135                 2140                 2145             


Asp Ile  Gln Glu Arg Asn Glu  Glu Ile Glu Lys Leu  Glu Phe Arg 
    2150                 2155                 2160             


Val Arg  Glu Leu Glu Gln Ala  Leu Leu Val Ser Ala  Asp Xaa Phe 
    2165                 2170                 2175             


Gln Lys  Val Glu Asp Arg Lys  His Phe Gly Ala Val  Glu Ala Lys 
    2180                 2185                 2190             


Pro Glu  Leu Ser Leu Glu Val  Gln Leu Gln Ala Glu  Arg Asp Ala 
    2195                 2200                 2205             


Ile Asp  Arg Lys Glu Lys Glu  Ile Xaa Asn Leu Glu  Glu Gln Leu 
    2210                 2215                 2220             


Glu Gln  Phe Arg Glu Glu Leu  Glu Asn Lys Asn Glu  Glu Val Gln 
    2225                 2230                 2235             


Gln Leu  His Met Gln Leu Glu  Ile Gln Lys Lys Glu  Ser Xaa Xaa 
    2240                 2245                 2250             


Arg Leu  Gln Glu Leu Glu Gln  Glu Asn Lys Leu Phe  Lys Asp Asp 
    2255                 2260                 2265             


Met Glu  Lys Leu Gly Leu Ala  Ile Lys Glu Ser Asp  Ala Met Ser 
    2270                 2275                 2280             


Xaa Gln  Asp Gln His Val Leu  Phe Gly Lys Phe Ala  Gln Ile Ile 
    2285                 2290                 2295             


Gln Glu  Lys Glu Val Glu Ile  Asp Gln Leu Asn Glu  Gln Val Xaa 
    2300                 2305                 2310             


Lys Leu  Gln Gln Gln Leu Lys  Ile Xaa Xaa Asp Asn  Lys Val Ile 
    2315                 2320                 2325             


Glu Glu  Lys Asn Glu Leu Ile  Arg Asp Leu Glu Xaa  Gln Ile Glu 
    2330                 2335                 2340             


Cys Leu  Met Ser Asp Gln Glu  Cys Val Lys Arg Asn  Arg Glu Glu 
    2345                 2350                 2355             


Glu Ile  Glu Gln Leu Asn Glu  Val Ile Glu Lys Leu  Gln Gln Glu 
    2360                 2365                 2370             


Leu Ala  Asn Ile Gly Gln Lys  Xaa Ser Met Asn Ala  His Ser Leu 
    2375                 2380                 2385             


Ser Glu  Glu Ala Asp Ser Leu  Lys His Gln Leu Asp  Val Val Ile 
    2390                 2395                 2400             


Ala Glu  Lys Leu Ala Leu Glu  Gln Gln Val Glu Xaa  Ala Asn Glu 
    2405                 2410                 2415             


Glu Met  Xaa Phe Met Lys Asn  Val Leu Lys Glu Xaa  Asn Phe Lys 
    2420                 2425                 2430             


Met Asn  Gln Leu Xaa Gln Glu  Leu Phe Ser Leu Lys  Arg Glu Arg 
    2435                 2440                 2445             


Glu Ser  Val Glu Lys Ile Gln  Ser Ile Pro Glu Asn  Ser Val Asn 
    2450                 2455                 2460             


Val Ala  Ile Asp His Leu Ser  Lys Asp Lys Pro Glu  Leu Glu Val 
    2465                 2470                 2475             


Val Leu  Xaa Glu Asp Ala Leu  Lys Ser Leu Glu Asn  Gln Xaa Tyr 
    2480                 2485                 2490             


Phe Lys  Ser Phe Glu Glu Asn  Gly Lys Gly Ser Ile  Ile Asn Leu 
    2495                 2500                 2505             


Glu Xaa  Arg Leu Leu Gln Leu  Glu Ser Xaa Val Ser  Ala Lys Asp 
    2510                 2515                 2520             


Leu Glu  Leu Xaa Gln Cys Tyr  Lys Gln Ile Lys Asp  Met Gln Glu 
    2525                 2530                 2535             


Gln Gly  Gln Phe Glu Xaa Glu  Met Leu Gln Lys Lys  Ile Val Asn 
    2540                 2545                 2550             


Leu Gln  Lys Ile Val Glu Glu  Lys Val Ala Ala Ala  Leu Val Ser 
    2555                 2560                 2565             


Gln Ile  Gln Leu Glu Ala Val  Gln Glu Tyr Ala Lys  Phe Cys Gln 
    2570                 2575                 2580             


Asp Asn  Gln Xaa Ile Ser Ser  Glu Pro Glu Arg Xaa  Asn Ile Gln 
    2585                 2590                 2595             


Asn Leu  Asn Gln Leu Arg Glu  Asp Glu Leu Gly Ser  Asp Ile Ser 
    2600                 2605                 2610             


Ala Leu  Xaa Leu Arg Ile Ser  Glu Leu Glu Ser Gln  Val Val Glu 
    2615                 2620                 2625             


Met His  Xaa Ser Leu Ile Leu  Glu Lys Glu Gln Val  Glu Ile Ala 
    2630                 2635                 2640             


Glu Lys  Asn Val Leu Glu Lys  Glu Lys Lys Leu Leu  Glu Leu Gln 
    2645                 2650                 2655             


Lys Leu  Leu Glu Gly Asn Glu  Lys Lys Gln Arg Glu  Lys Glu Lys 
    2660                 2665                 2670             


Lys Arg  Ser Pro Gln Asp Val  Glu Val Leu Lys Xaa  Xaa Xaa Glu 
    2675                 2680                 2685             


Leu Phe  His Ser Asn Glu Glu  Ser Gly Phe Phe Asn  Glu Leu Glu 
    2690                 2695                 2700             


Ala Leu  Arg Ala Glu Ser Val  Ala Xaa Lys Ala Glu  Leu Ala Ser 
    2705                 2710                 2715             


Tyr Lys  Glu Lys Ala Glu Lys  Leu Gln Glu Glu Leu  Leu Val Lys 
    2720                 2725                 2730             


Glu Xaa  Asn Met Xaa Ser Leu  Gln Lys Asp Leu Ser  Gln Val Arg 
    2735                 2740                 2745             


Asp His  Leu Ala Glu Ala Lys  Glu Lys Leu Ser Ile  Leu Glu Lys 
    2750                 2755                 2760             


Glu Asp  Glu Xaa Glu Val Gln  Glu Ser Lys Lys Ala  Cys Met Phe 
    2765                 2770                 2775             


Glu Pro  Leu Pro Ile Lys Leu  Ser Lys Ser Ile Ala  Ser Gln Xaa 
    2780                 2785                 2790             


Asp Gly  Xaa Leu Lys Ile Ser  Ser Ser Asn Gln Xaa  Pro Gln Ile 
    2795                 2800                 2805             


Leu Val  Lys Asn Ala Gly Ile  Gln Ile Asn Leu Gln  Ser Glu Cys 
    2810                 2815                 2820             


Ser Ser  Glu Glu Val Xaa Glu  Ile Ile Ser Gln Phe  Xaa Glu Lys 
    2825                 2830                 2835             


Ile Glu  Lys Met Gln Glu Leu  His Ala Ala Glu Ile  Leu Asp Met 
    2840                 2845                 2850             


Glu Ser  Arg His Ile Ser Glu  Xaa Glu Xaa Leu Lys  Arg Glu His 
    2855                 2860                 2865             


Tyr Val  Ala Val Gln Leu Leu  Lys Glu Glu Cys Gly  Xaa Leu Lys 
    2870                 2875                 2880             


Ala Val  Ile Gln Cys Leu Arg  Ser Lys Glu Val Phe  Gly Phe Tyr 
    2885                 2890                 2895             


Asn Met  Cys Phe Ser Xaa Leu  Cys Asp Ser Gly Ser  Asp Trp Gly 
    2900                 2905                 2910             


Gln Gly  Ile Tyr Leu Xaa His  Ser Gln Gly Phe Asp  Ile Ala Ser 
    2915                 2920                 2925             


Glu Gly  Arg Gly Glu Glu Ser  Glu Ser Ala Xaa Asp  Ser Phe Pro 
    2930                 2935                 2940             


Lys Lys  Ile Lys Gly Leu Leu  Arg Ala Val His Asn  Glu Gly Met 
    2945                 2950                 2955             


Gln Val  Leu Ser Leu Xaa Glu  Ser Pro Tyr Ser Asp  Gly Glu Asp 
    2960                 2965                 2970             


His Ser  Ile Gln Gln Val Ser  Glu Pro Trp Leu Glu  Glu Arg Lys 
    2975                 2980                 2985             


Ala Tyr  Ile Asn Xaa Ile Ser  Ser Leu Lys Asp Leu  Ile Xaa Lys 
    2990                 2995                 3000             


Met Gln  Leu Gln Arg Glu Ala  Glu Val Tyr Asp Ser  Ser Gln Ser 
    3005                 3010                 3015             


His Glu  Ser Phe Ser Asp Trp  Arg Gly Glu Leu Leu  Leu Ala Leu 
    3020                 3025                 3030             


Gln Gln  Val Phe Leu Glu Glu  Arg Ser Val Leu Leu  Ala Ala Phe 
    3035                 3040                 3045             


Arg Xaa  Glu Leu Xaa Ala Leu  Gly Xaa Xaa Asp Ala  Val Gly Leu 
    3050                 3055                 3060             


Leu Asn  Cys Leu Glu Gln Arg  Ile Gln Glu Gln Gly  Val Glu Tyr 
    3065                 3070                 3075             


Gln Ala  Ala Met Glu Cys Leu  Gln Lys Ala Asp Arg  Arg Ser Leu 
    3080                 3085                 3090             


Leu Ser  Glu Ile Gln Ala Leu  His Ala Gln Met Asn  Gly Arg Lys 
    3095                 3100                 3105             


Ile Xaa  Leu Lys Arg Glu Gln  Glu Ser Glu Lys Pro  Ser Gln Glu 
    3110                 3115                 3120             


Leu Leu  Glu Tyr Asn Ile Gln  Gln Lys Gln Ser Gln  Met Leu Glu 
    3125                 3130                 3135             


Met Gln  Val Glu Leu Ser Ser  Met Lys Asp Arg Ala  Xaa Glu Leu 
    3140                 3145                 3150             


Gln Glu  Gln Leu Ser Ser Glu  Lys Met Val Val Ala  Glu Leu Lys 
    3155                 3160                 3165             


Ser Glu  Leu Ala Gln Xaa Lys  Leu Glu Leu Glu Xaa  Xaa Leu Lys 
    3170                 3175                 3180             


Ala Gln  His Lys His Leu Lys  Glu Leu Glu Ala Phe  Arg Leu Glu 
    3185                 3190                 3195             


Val Lys  Asp Lys Xaa Asp Glu  Val His Leu Leu Asn  Asp Xaa Leu 
    3200                 3205                 3210             


Ala Ser  Glu Gln Lys Lys Ser  Arg Glu Leu Gln Trp  Ala Leu Glu 
    3215                 3220                 3225             


Lys Glu  Lys Ala Lys Leu Gly  Arg Ser Glu Glu Arg  Asp Lys Glu 
    3230                 3235                 3240             


Glu Leu  Glu Asp Leu Lys Phe  Ser Leu Glu Ser Gln  Lys Gln Arg 
    3245                 3250                 3255             


Asn Leu  Gln Leu Asn Leu Leu  Leu Glu Gln Gln Lys  Gln Leu Leu 
    3260                 3265                 3270             


Asn Glu  Ser Gln Gln Lys Ile  Glu Ser Gln Arg Met  Leu Tyr Asp 
    3275                 3280                 3285             


Ala Gln  Leu Ser Glu Glu Gln  Gly Arg Asn Leu Glu  Leu Gln Val 
    3290                 3295                 3300             


Leu Leu  Glu Ser Glu Lys Val  Arg Ile Arg Glu Met  Ser Ser Xaa 
    3305                 3310                 3315             


Leu Asp  Arg Glu Arg Glu Leu  His Ala Gln Leu Gln  Ser Ser Asp 
    3320                 3325                 3330             


Gly Xaa  Gly Gln Ser Arg Pro  Pro Leu Pro Ser Glu  Asp Leu Leu 
    3335                 3340                 3345             


Lys Glu  Leu Gln Lys Gln Leu  Glu Glu Lys His Ser  Arg Ile Val 
    3350                 3355                 3360             


Glu Leu  Leu Asn Glu Xaa Glu  Lys Tyr Lys Leu Asp  Ser Leu Gln 
    3365                 3370                 3375             


Xaa Arg  Gln Gln Met Glu Lys  Asp Arg Gln Val His  Arg Lys Xaa 
    3380                 3385                 3390             


Leu Gln  Xaa Glu Gln Glu Ala  Asn Xaa Glu Gly Gln  Lys Lys Met 
    3395                 3400                 3405             


His Glu  Leu Gln Ser Lys Val  Glu Asp Leu Gln Arg  Gln Leu Glu 
    3410                 3415                 3420             


Glu Lys  Arg Gln Gln Val Tyr  Lys Leu Asp Leu Glu  Gly Gln Arg 
    3425                 3430                 3435             


Leu Gln  Gly Ile Met Gln Glu  Phe Gln Lys Gln Glu  Leu Glu Arg 
    3440                 3445                 3450             


Glu Glu  Lys Arg Glu Ser Arg  Arg Ile Leu Tyr Gln  Asn Leu Asn 
    3455                 3460                 3465             


Glu Pro  Xaa Xaa Trp Ser Leu  Xaa Ser Asp Arg Xaa  Arg Asn Trp 
    3470                 3475                 3480             


Val Leu  Gln Gln Lys Ile Glu  Gly Glu Xaa Lys Glu  Ser Asn Tyr 
    3485                 3490                 3495             


Ala Lys  Leu Ile Glu Met Asn  Gly Gly Gly Xaa Gly  Cys Asn His 
    3500                 3505                 3510             


Glu Leu  Glu Met Ile Arg Gln  Lys Leu Gln Cys Val  Ala Ser Lys 
    3515                 3520                 3525             


Leu Gln  Val Leu Pro Gln Lys  Ala Ser Glu Arg Leu  Gln Phe Glu 
    3530                 3535                 3540             


Xaa Ala  Asp Asp Glu Asp Phe  Ile Trp Val Gln Glu  Asn Ile Asp 
    3545                 3550                 3555             


Glu Ile  Ile Leu Gln Leu Gln  Lys Leu Xaa Gly Gln  Gln Gly Glu 
    3560                 3565                 3570             


Glu Pro  Ser Leu Val Ser Pro  Ser Xaa Ser Cys Gly  Ser Leu Xaa 
    3575                 3580                 3585             


Glu Arg  Leu Leu Arg Gln Asn  Ala Glu Leu Xaa Gly  His Ile Ser 
    3590                 3595                 3600             


Gln Leu  Xaa Glu Glu Lys Asn  Asp Leu Arg Asn Met  Val Met Lys 
    3605                 3610                 3615             


Leu Glu  Glu Gln Ile Arg Trp  Tyr Arg Gln Xaa Gly  Ala Gly Arg 
    3620                 3625                 3630             


Asp Asn  Ser Ser Arg Phe Ser  Leu Asn Gly Gly Ala  Asn Ile Glu 
    3635                 3640                 3645             


Ala Ile  Ile Ala Ser Glu Lys  Glu Val Trp Asn Arg  Glu Lys Leu 
    3650                 3655                 3660             


Xaa Leu  Gln Lys Ser Leu Lys  Arg Ala Glu Ala Glu  Val Tyr Lys 
    3665                 3670                 3675             


Leu Lys  Ala Glu Leu Arg Asn  Asp Ser Leu Leu Gln  Xaa Leu Ser 
    3680                 3685                 3690             


Pro Asp  Ser Glu His Val Xaa  Leu Lys Arg Ile Tyr  Gly Lys Tyr 
    3695                 3700                 3705             


Leu Arg  Ala Glu Ser Phe Arg  Lys Ala Leu Ile Tyr  Gln Lys Lys 
    3710                 3715                 3720             


Tyr Leu  Leu Leu Leu Leu Gly  Gly Phe Gln Glu Cys  Glu Asp Ala 
    3725                 3730                 3735             


Xaa Leu  Ala Leu Leu Ala Arg  Met Gly Gly Gln Pro  Ala Phe Xaa 
    3740                 3745                 3750             


Asp Leu  Glu Val Ile Xaa Asn  Arg Pro Lys Gly Phe  Xaa Arg Phe 
    3755                 3760                 3765             


Arg Ser  Ala Val Arg Val Ser  Ile Ala Ile Ser Arg  Met Lys Phe 
    3770                 3775                 3780             


Leu Val  Arg Arg Trp His Arg  Val Xaa Gly Ser Val  Ser Ile Asn 
    3785                 3790                 3795             


Ile Asn  Arg Asp Gly Phe Gly  Leu Asn Gln Gly Ala  Glu Lys Xaa 
    3800                 3805                 3810             


Asp Ser  Phe Tyr His Ser Ser  Gly Gly Leu Glu Leu  Tyr Gly Glu 
    3815                 3820                 3825             


Pro Arg  His Xaa Xaa Tyr Arg  Ser Arg Ser Asp Leu  Asp Tyr Ile 
    3830                 3835                 3840             


Arg Ser  Pro Leu Pro Phe Gln  Asn Arg Tyr Pro Gly  Xaa Pro Ala 
    3845                 3850                 3855             


Asp Phe  Asn Pro Gly Ser Leu  Ala Cys Ser Gln Leu  Gln Asn Tyr 
    3860                 3865                 3870             


Asp Pro  Asp Arg Ala Leu Xaa  Asp Tyr Ile Xaa Arg  Leu Glu Ala 
    3875                 3880                 3885             


Leu Gln  Arg Arg Leu Gly Xaa  Ile Gln Ser Gly Ser  Xaa Xaa Gln 
    3890                 3895                 3900             


Phe His  Ala Gly Met Arg Arg  
    3905                 3910 


<210> 2135
<211> 232
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<400> 2135
Pro Ser Lys Lys Gln Lys Lys Lys Arg Lys Xaa Ser Ser Ser Lys His 
1               5                   10                  15      


Asp Val Ser Ala His His Asp Leu Asn Ile Asp Gln Ser Gln Cys Asn 
            20                  25                  30          


Glu Met Tyr Ile Asn Ser Ser Gln Arg Val Glu Ser Xaa Val Ile Pro 
        35                  40                  45              


Glu Ser Xaa Ile Met Arg Xaa Leu His Ser Gly Glu Ile Xaa Ser His 
    50                  55                  60                  


Glu Gln Gly Phe Ser Val Glu Leu Glu Ser Glu Ile Ser Xaa Xaa Ala 
65                  70                  75                  80  


Asp Asp Cys Ser Ser Glu Glu Glu Glu Phe Gly Val Asp Asp Ser Tyr 
                85                  90                  95      


Ser Glu Gln Gly Ala Gln Asp Ser Pro Xaa His Leu Glu Met Met Glu 
            100                 105                 110         


Ser Glu Leu Ala Gly Lys Gln His Glu Ile Glu Glu Leu Asn Arg Glu 
        115                 120                 125             


Leu Glu Glu Met Arg Val Xaa Tyr Gly Xaa Glu Gly Leu Gln Gln Leu 
    130                 135                 140                 


Gln Glu Phe Glu Ala Ala Ile Lys Gln Arg Asp Gly Ile Ile Xaa Gln 
145                 150                 155                 160 


Leu Xaa Ala Asn Leu Gln Gln Ala Arg Arg Glu Lys Asp Glu Xaa Met 
                165                 170                 175     


Arg Glu Phe Leu Glu Leu Xaa Glu Gln Ser Gln Lys Leu Gln Ile Gln 
            180                 185                 190         


Phe Gln Gln Leu Gln Ala Ser Glu Xaa Leu Arg Asn Ser Xaa His Ser 
        195                 200                 205             


Ser Xaa Ala Ala Asp Leu Leu Gln Ala Lys Gln Gln Ile Leu Xaa His 
    210                 215                 220                 


Gln Gln Gln Leu Glu Glu Gln Asp 
225                 230         


<210> 2136
<211> 318
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<400> 2136
Xaa His Tyr Val Ala Val Gln Leu Leu Lys Glu Glu Cys Gly Xaa Leu 
1               5                   10                  15      


Lys Ala Val Ile Gln Cys Leu Arg Ser Lys Glu Gly Ser Ser Ile Pro 
            20                  25                  30          


Glu Leu Ala His Ser Asp Ala Tyr Gln Xaa Arg Glu Ile Cys Ser Ser 
        35                  40                  45              


Asp Ser Gly Ser Asp Trp Gly Gln Gly Ile Tyr Leu Xaa His Ser Gln 
    50                  55                  60                  


Gly Phe Asp Ile Ala Ser Glu Gly Arg Gly Glu Glu Ser Glu Ser Ala 
65                  70                  75                  80  


Xaa Asp Ser Phe Pro Lys Lys Ile Lys Gly Leu Leu Arg Ala Val His 
                85                  90                  95      


Asn Glu Gly Met Gln Val Leu Ser Leu Xaa Glu Ser Pro Tyr Ser Asp 
            100                 105                 110         


Gly Glu Asp His Ser Ile Gln Gln Val Ser Glu Pro Trp Leu Glu Glu 
        115                 120                 125             


Arg Lys Ala Tyr Ile Asn Xaa Ile Ser Ser Leu Lys Asp Leu Ile Xaa 
    130                 135                 140                 


Lys Met Gln Leu Gln Arg Glu Ala Glu Val Tyr Asp Ser Ser Gln Ser 
145                 150                 155                 160 


His Glu Ser Phe Ser Asp Trp Arg Gly Glu Leu Leu Leu Ala Leu Gln 
                165                 170                 175     


Gln Val Phe Leu Glu Glu Arg Ser Val Leu Leu Ala Ala Phe Arg Xaa 
            180                 185                 190         


Glu Leu Xaa Ala Leu Gly Xaa Xaa Asp Ala Val Gly Leu Leu Asn Cys 
        195                 200                 205             


Leu Glu Gln Arg Ile Gln Glu Gln Gly Val Glu Tyr Gln Ala Ala Met 
    210                 215                 220                 


Glu Cys Leu Gln Lys Ala Asp Arg Arg Ser Leu Leu Ser Glu Ile Gln 
225                 230                 235                 240 


Ala Leu His Ala Gln Met Asn Gly Arg Lys Ile Xaa Leu Lys Arg Glu 
                245                 250                 255     


Gln Glu Ser Glu Lys Pro Ser Gln Gly Met Leu Tyr Asp Lys Leu Ile 
            260                 265                 270         


Trp Leu His Lys Gln Val Lys Arg Phe His Phe Val Phe Phe Leu Ile 
        275                 280                 285             


Ile Ile Lys Leu Lys His Ile Phe Leu Val Xaa Phe Ser Ser His Ser 
    290                 295                 300                 


His Asn Val Lys Asp Xaa Ile Tyr Ile Asn Tyr Ser Arg Gly 
305                 310                 315             


<210> 2137
<211> 151
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<400> 2137
Ala Ala Ala Ala Leu Asn Gly Val Asp Arg Arg Ser Leu Gln Arg Ser 
1               5                   10                  15      


Ala Arg Leu Ala Leu Glu Val Leu Glu Arg Ala Lys Arg Arg Ala Val 
            20                  25                  30          


Asp Trp His Ala Leu Glu Arg Pro Lys Gly Cys Met Gly Val Leu Ala 
        35                  40                  45              


Arg Glu Ala Pro His Leu Glu Lys Gln Pro Ala Ala Gly Pro Gln Arg 
    50                  55                  60                  


Val Leu Pro Gly Glu Lys Tyr Tyr Ser Ser Val Pro Glu Glu Gly Gly 
65                  70                  75                  80  


Ala Xaa His Val Tyr Arg Tyr His Arg Gly Glu Ser Lys Leu His Met 
                85                  90                  95      


Cys Leu Asp Ile Gly Asn Gly Gln Ala Glu Asn Ile Ser Lys Asp Leu 
            100                 105                 110         


Tyr Ile Glu Val Tyr Pro Gly Xaa Tyr Ser Val Xaa Val Gly Ser Asn 
        115                 120                 125             


Asp Leu Xaa Lys Lys Xaa His Val Val Ala Val Asp Ser Gly Gln Ser 
    130                 135                 140                 


Val Asp Leu Val Phe Pro Val 
145                 150     


<210> 2138
<211> 101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 2138
Met Ala Glu Phe Met Asp Tyr Xaa Ser Ser Gln Cys Gly Lys Tyr Tyr 
1               5                   10                  15      


Ser Ser Val Pro Glu Glu Gly Gly Ala Xaa His Val Tyr Arg Tyr His 
            20                  25                  30          


Arg Gly Glu Ser Lys Leu His Met Cys Leu Asp Ile Gly Asn Gly Gln 
        35                  40                  45              


Arg Lys Asp Arg Lys Lys Xaa Ser Leu Gly Pro Gly Gly Ser Tyr Gln 
    50                  55                  60                  


Ile Ser Glu His Ala Pro Glu Ala Ser Gln Pro Ala Glu Asn Ile Ser 
65                  70                  75                  80  


Lys Asp Leu Tyr Ile Glu Val Tyr Pro Gly Xaa Tyr Ser Val Xaa Val 
                85                  90                  95      


Gly Ser Asn Asp Leu 
            100     


<210> 2139
<211> 183
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 2139
Met Asp Asn Cys Leu Ala Ala Ala Ala Leu Asn Gly Val Asp Arg Arg 
1               5                   10                  15      


Ser Leu Gln Arg Ser Ala Arg Leu Ala Leu Glu Val Leu Glu Arg Ala 
            20                  25                  30          


Lys Arg Arg Ala Val Asp Trp His Ala Leu Glu Arg Pro Lys Gly Cys 
        35                  40                  45              


Met Gly Val Leu Ala Arg Glu Ala Pro His Leu Glu Lys Gln Pro Ala 
    50                  55                  60                  


Ala Gly Pro Gln Arg Val Leu Pro Gly Glu Lys Tyr Tyr Ser Ser Val 
65                  70                  75                  80  


Pro Glu Glu Gly Gly Ala Xaa His Val Tyr Arg Tyr His Arg Gly Glu 
                85                  90                  95      


Ser Lys Leu His Met Cys Leu Asp Ile Gly Asn Gly Gln Arg Lys Asp 
            100                 105                 110         


Arg Lys Lys Xaa Ser Leu Gly Pro Gly Gly Ser Tyr Gln Ile Ser Glu 
        115                 120                 125             


His Ala Pro Glu Ala Ser Gln Pro Ala Glu Asn Ile Ser Lys Asp Leu 
    130                 135                 140                 


Tyr Ile Glu Val Tyr Pro Gly Xaa Tyr Ser Val Xaa Val Gly Ser Asn 
145                 150                 155                 160 


Asp Leu Xaa Lys Lys Xaa His Val Val Ala Val Asp Ser Gly Gln Ser 
                165                 170                 175     


Val Asp Leu Val Phe Pro Val 
            180             


<210> 2140
<211> 168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<400> 2140
Met Asp Asn Cys Leu Ala Ala Ala Ala Leu Asn Gly Val Asp Arg Arg 
1               5                   10                  15      


Ser Leu Gln Arg Ser Ala Arg Leu Ala Leu Glu Val Leu Glu Arg Ala 
            20                  25                  30          


Lys Arg Arg Ala Val Asp Trp His Ala Leu Glu Arg Pro Lys Gly Cys 
        35                  40                  45              


Met Gly Val Leu Ala Arg Glu Ala Pro His Leu Glu Lys Gln Pro Ala 
    50                  55                  60                  


Ala Gly Pro Gln Arg Val Leu Pro Gly Glu Lys Tyr Tyr Ser Ser Val 
65                  70                  75                  80  


Pro Glu Glu Gly Gly Ala Xaa His Val Tyr Arg Tyr His Arg Gly Glu 
                85                  90                  95      


Ser Lys Leu His Met Cys Leu Asp Ile Gly Asn Gly Gln Arg Lys Asp 
            100                 105                 110         


Arg Lys Lys Xaa Ser Leu Gly Pro Gly Gly Ser Tyr Gln Ile Ser Glu 
        115                 120                 125             


His Ala Pro Glu Ala Ser Gln Pro Val Ser Xaa Glu Leu Leu Xaa His 
    130                 135                 140                 


Trp Val Ser Pro Pro Leu Gln Leu His Glu Pro Val Asp Met Val Leu 
145                 150                 155                 160 


Arg Gly Leu Phe Glu Leu Ser Leu 
                165             


<210> 2141
<211> 183
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 2141
Met Asp Asn Cys Leu Ala Ala Ala Ala Leu Asn Gly Val Asp Arg Arg 
1               5                   10                  15      


Ser Leu Gln Arg Ser Ala Arg Leu Ala Leu Glu Val Leu Glu Arg Ala 
            20                  25                  30          


Lys Arg Arg Ala Val Asp Trp His Ala Leu Glu Arg Pro Lys Gly Cys 
        35                  40                  45              


Met Gly Val Leu Ala Arg Glu Ala Pro His Leu Glu Lys Gln Pro Ala 
    50                  55                  60                  


Ala Gly Pro Gln Arg Val Leu Pro Gly Glu Arg Glu Glu Arg Pro Pro 
65                  70                  75                  80  


Xaa Leu Ser Ala Ser Phe Arg Xaa Met Ala Glu Phe Met Asp Tyr Xaa 
                85                  90                  95      


Ser Ser Gln Cys Gly Lys Tyr Tyr Ser Ser Val Pro Glu Glu Gly Gly 
            100                 105                 110         


Ala Xaa His Val Tyr Arg Tyr His Arg Gly Glu Ser Lys Leu His Met 
        115                 120                 125             


Cys Leu Asp Ile Gly Asn Gly Gln Ala Glu Asn Ile Ser Lys Asp Leu 
    130                 135                 140                 


Tyr Ile Glu Val Tyr Pro Gly Xaa Tyr Ser Val Xaa Val Gly Ser Asn 
145                 150                 155                 160 


Asp Leu Xaa Lys Lys Xaa His Val Val Ala Val Asp Ser Gly Gln Ser 
                165                 170                 175     


Val Asp Leu Val Phe Pro Val 
            180             


<210> 2142
<211> 210
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<400> 2142
Met Asp Asn Cys Leu Ala Ala Ala Ala Leu Asn Gly Val Asp Arg Arg 
1               5                   10                  15      


Ser Leu Gln Arg Ser Ala Arg Leu Ala Leu Glu Val Leu Glu Arg Ala 
            20                  25                  30          


Lys Arg Arg Ala Val Asp Trp His Ala Leu Glu Arg Pro Lys Gly Cys 
        35                  40                  45              


Met Gly Val Leu Ala Arg Glu Ala Pro His Leu Glu Lys Gln Pro Ala 
    50                  55                  60                  


Ala Gly Pro Gln Arg Val Leu Pro Gly Glu Arg Glu Glu Arg Pro Pro 
65                  70                  75                  80  


Xaa Leu Ser Ala Ser Phe Arg Xaa Met Ala Glu Phe Met Asp Tyr Xaa 
                85                  90                  95      


Ser Ser Gln Cys Gly Lys Tyr Tyr Ser Ser Val Pro Glu Glu Gly Gly 
            100                 105                 110         


Ala Xaa His Val Tyr Arg Tyr His Arg Gly Glu Ser Lys Leu His Met 
        115                 120                 125             


Cys Leu Asp Ile Gly Asn Gly Gln Arg Lys Asp Arg Lys Lys Xaa Ser 
    130                 135                 140                 


Leu Gly Pro Gly Gly Ser Tyr Gln Ile Ser Glu His Ala Pro Glu Ala 
145                 150                 155                 160 


Ser Gln Pro Ala Glu Asn Ile Ser Lys Asp Leu Tyr Ile Glu Val Tyr 
                165                 170                 175     


Pro Gly Xaa Tyr Ser Val Xaa Val Gly Ser Asn Asp Leu Xaa Lys Lys 
            180                 185                 190         


Xaa His Val Val Ala Val Asp Ser Gly Gln Ser Val Asp Leu Val Phe 
        195                 200                 205             


Pro Val 
    210 


<210> 2143
<211> 179
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<400> 2143
Met Asp Asn Cys Leu Ala Ala Ala Ala Leu Asn Gly Val Asp Arg Arg 
1               5                   10                  15      


Ser Leu Gln Arg Ser Ala Arg Leu Ala Leu Glu Val Leu Glu Arg Ala 
            20                  25                  30          


Lys Arg Arg Ala Val Asp Trp His Ala Leu Glu Arg Pro Lys Gly Cys 
        35                  40                  45              


Met Gly Val Leu Ala Arg Glu Ala Pro His Leu Glu Lys Gln Pro Ala 
    50                  55                  60                  


Ala Gly Pro Gln Arg Val Leu Pro Gly Glu Arg Glu Glu Arg Pro Pro 
65                  70                  75                  80  


Xaa Leu Ser Ala Ser Phe Arg Xaa Met Ala Glu Phe Met Asp Tyr Xaa 
                85                  90                  95      


Ser Ser Gln Cys Gly Lys Tyr Tyr Ser Ser Val Pro Glu Glu Gly Gly 
            100                 105                 110         


Ala Xaa His Val Tyr Arg Tyr His Arg Gly Glu Ser Lys Leu His Met 
        115                 120                 125             


Cys Leu Asp Ile Gly Asn Gly Gln Arg Lys Asp Arg Lys Lys Xaa Ser 
    130                 135                 140                 


Leu Gly Pro Gly Gly Ser Tyr Gln Ile Ser Glu His Ala Pro Glu Ala 
145                 150                 155                 160 


Ser Gln Pro Val Ser Xaa Glu Leu Leu Xaa His Trp Val Ser Pro Pro 
                165                 170                 175     


Leu Gln Leu 
            


<210> 2144
<211> 195
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<400> 2144
Met Asp Asn Cys Leu Ala Ala Ala Ala Leu Asn Gly Val Asp Arg Arg 
1               5                   10                  15      


Ser Leu Gln Arg Ser Ala Arg Leu Ala Leu Glu Val Leu Glu Arg Ala 
            20                  25                  30          


Lys Arg Arg Ala Val Asp Trp His Ala Leu Glu Arg Pro Lys Gly Cys 
        35                  40                  45              


Met Gly Val Leu Ala Arg Glu Ala Pro His Leu Glu Lys Gln Pro Ala 
    50                  55                  60                  


Ala Gly Pro Gln Arg Val Leu Pro Gly Glu Arg Glu Glu Arg Pro Pro 
65                  70                  75                  80  


Xaa Leu Ser Ala Ser Phe Arg Xaa Met Ala Glu Phe Met Asp Tyr Xaa 
                85                  90                  95      


Ser Ser Gln Cys Gly Lys Tyr Tyr Ser Ser Val Pro Glu Glu Gly Gly 
            100                 105                 110         


Ala Xaa His Val Tyr Arg Tyr His Arg Gly Glu Ser Lys Leu His Met 
        115                 120                 125             


Cys Leu Asp Ile Gly Asn Gly Gln Arg Lys Asp Arg Lys Lys Xaa Ser 
    130                 135                 140                 


Leu Gly Pro Gly Gly Ser Tyr Gln Ile Ser Glu His Ala Pro Glu Ala 
145                 150                 155                 160 


Ser Gln Pro Val Ser Xaa Glu Leu Leu Xaa His Trp Val Ser Pro Pro 
                165                 170                 175     


Leu Gln Leu His Glu Pro Val Asp Met Val Leu Arg Gly Leu Phe Glu 
            180                 185                 190         


Leu Ser Leu 
        195 


<210> 2145
<211> 316
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<400> 2145
Met Ala Ser Arg Leu Leu Leu Asn Asn Gly Ala Lys Met Pro Ile Leu 
1               5                   10                  15      


Gly Leu Gly Xaa Trp Lys Ser Pro Pro Gly Gln Val Xaa Glu Ala Val 
            20                  25                  30          


Lys Val Ala Ile Asp Val Gly Tyr Arg His Ile Asp Cys Ala His Val 
        35                  40                  45              


Tyr Gln Asn Glu Asn Glu Val Gly Val Ala Ile Gln Glu Lys Leu Arg 
    50                  55                  60                  


Glu Gln Val Val Lys Arg Glu Glu Leu Phe Ile Val Ser Lys Leu Trp 
65                  70                  75                  80  


Cys Xaa Tyr His Glu Lys Gly Leu Val Lys Gly Ala Cys Gln Lys Xaa 
                85                  90                  95      


Leu Ser Asp Leu Lys Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp 
            100                 105                 110         


Pro Xaa Gly Phe Lys Pro Gly Lys Glu Phe Phe Pro Leu Asp Glu Ser 
        115                 120                 125             


Gly Asn Val Val Pro Ser Asp Xaa Asn Ile Leu Asp Xaa Trp Ala Ala 
    130                 135                 140                 


Met Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Ile Ser 
145                 150                 155                 160 


Asn Phe Asn His Leu Gln Val Glu Met Ile Leu Asn Lys Pro Gly Leu 
                165                 170                 175     


Lys Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Xaa 
            180                 185                 190         


Gln Glu Lys Leu Ile Gln Tyr Cys Gln Ser Lys Gly Ile Val Val Xaa 
        195                 200                 205             


Ala Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu 
    210                 215                 220                 


Asp Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Ala Ile Ala Ala Lys 
225                 230                 235                 240 


His Asn Lys Xaa Xaa Ala Gln Val Leu Ile Arg Phe Pro Met Gln Arg 
                245                 250                 255     


Asn Leu Val Val Ile Pro Lys Ser Val Xaa Pro Glu Arg Ile Ala Glu 
            260                 265                 270         


Asn Phe Lys Val Phe Asp Phe Glu Leu Ser Ser Gln Asp Met Xaa Xaa 
        275                 280                 285             


Leu Leu Ser Tyr Asn Arg Asn Trp Arg Val Cys Ala Leu Leu Ser Cys 
    290                 295                 300                 


Xaa Ser His Lys Asp Tyr Pro Phe His Glu Glu Phe 
305                 310                 315     


<210> 2146
<211> 263
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<400> 2146
Met Ala Ser Arg Leu Leu Leu Asn Asn Gly Ala Lys Met Pro Ile Leu 
1               5                   10                  15      


Gly Leu Gly Xaa Trp Lys Ser Pro Pro Gly Gln Val Xaa Glu Ala Val 
            20                  25                  30          


Lys Val Ala Ile Asp Val Gly Tyr Arg His Ile Asp Cys Ala His Val 
        35                  40                  45              


Tyr Gln Asn Glu Asn Glu Val Gly Val Ala Ile Gln Glu Lys Leu Arg 
    50                  55                  60                  


Glu Gln Val Val Lys Arg Glu Glu Leu Phe Ile Val Ser Lys Leu Trp 
65                  70                  75                  80  


Cys Xaa Tyr His Glu Lys Gly Leu Val Lys Gly Ala Cys Gln Lys Xaa 
                85                  90                  95      


Leu Ser Asp Leu Lys Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp 
            100                 105                 110         


Pro Xaa Gly Phe Lys Pro Gly Lys Glu Phe Phe Pro Leu Asp Glu Ser 
        115                 120                 125             


Gly Asn Val Val Pro Ser Asp Xaa Asn Ile Leu Asp Xaa Trp Ala Ala 
    130                 135                 140                 


Met Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Ile Ser 
145                 150                 155                 160 


Asn Phe Asn His Leu Gln Val Glu Met Ile Leu Asn Lys Pro Gly Leu 
                165                 170                 175     


Lys Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Xaa 
            180                 185                 190         


Gln Glu Lys Leu Ile Gln Tyr Cys Gln Ser Lys Gly Ile Val Val Xaa 
        195                 200                 205             


Ala Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu 
    210                 215                 220                 


Asp Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Ala Ile Ala Ala Lys 
225                 230                 235                 240 


His Asn Lys Xaa Xaa Ala Gln Val Gln Pro Leu Gln Val Leu Leu Xaa 
                245                 250                 255     


Val His Asn Cys Leu His Ser 
            260             


<210> 2147
<211> 102
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<400> 2147
Met Ala Ser Arg Leu Leu Leu Asn Asn Gly Ala Lys Met Pro Ile Leu 
1               5                   10                  15      


Gly Leu Gly Xaa Trp Lys Ser Pro Pro Gly Gln Val Xaa Glu Ala Val 
            20                  25                  30          


Lys Val Ala Ile Asp Val Gly Tyr Arg His Ile Asp Cys Ala His Val 
        35                  40                  45              


Tyr Gln Asn Glu Asn Glu Val Gly Val Ala Ile Gln Glu Lys Leu Arg 
    50                  55                  60                  


Glu Gln Val Val Lys Arg Glu Glu Leu Phe Ile Val Ser Lys Pro Gly 
65                  70                  75                  80  


Ser Cys Leu Val Ala Gly Asn Asp Asp Met Cys Pro Leu Ala Gly Leu 
                85                  90                  95      


Ala Val Val His Val Pro 
            100         


<210> 2148
<211> 297
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<400> 2148
Met Asp Ser Lys Tyr Gln Cys Val Lys Leu Asn Asp Gly His Phe Met 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Xaa Tyr Ala Pro Ala Glu Val Pro Lys Ser 
            20                  25                  30          


Lys Ala Leu Glu Ala Val Lys Leu Ala Ile Glu Ala Gly Phe His His 
        35                  40                  45              


Ile Asp Ser Ala His Val Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Xaa Ser Lys Leu Trp Ser Asn Ser His Arg Pro Glu Leu Val Arg 
                85                  90                  95      


Pro Ala Leu Glu Arg Ser Leu Lys Asn Leu Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Leu Ile His Phe Pro Val Ser Val Lys Ala Met Glu Lys Cys 
        115                 120                 125             


Lys Asp Ala Gly Leu Ala Lys Ser Ile Gly Val Ser Asn Phe Asn His 
    130                 135                 140                 


Arg Leu Leu Glu Met Ile Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro 
145                 150                 155                 160 


Val Cys Asn Gln Val Glu Cys His Pro Tyr Phe Asn Gln Arg Lys Leu 
                165                 170                 175     


Leu Asp Phe Cys Lys Ser Lys Asp Ile Val Leu Val Ala Tyr Ser Ala 
            180                 185                 190         


Leu Gly Ser His Arg Glu Glu Pro Trp Val Asp Pro Asn Ser Pro Val 
        195                 200                 205             


Leu Leu Glu Asp Pro Val Leu Cys Ala Leu Ala Lys Lys His Lys Arg 
    210                 215                 220                 


Xaa Pro Ala Leu Ile Ala Leu Arg Tyr Gln Leu Gln Arg Gly Val Val 
225                 230                 235                 240 


Val Leu Ala Lys Ser Tyr Asn Glu Gln Arg Ile Arg Gln Asn Val Gln 
                245                 250                 255     


Val Phe Glu Phe Gln Leu Xaa Ser Glu Glu Met Lys Ala Ile Asp Gly 
            260                 265                 270         


Leu Asn Arg Asn Val Arg Tyr Leu Xaa Leu Asp Ile Phe Ala Gly Pro 
        275                 280                 285             


Pro Asn Tyr Pro Phe Ser Asp Glu Tyr 
    290                 295         


<210> 2149
<211> 139
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 2149
Met Asp Ser Lys Tyr Gln Cys Val Lys Leu Asn Asp Gly His Phe Met 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Xaa Tyr Ala Pro Ala Glu Val Pro Lys Ser 
            20                  25                  30          


Lys Ala Leu Glu Ala Val Lys Leu Ala Ile Glu Ala Gly Phe His His 
        35                  40                  45              


Ile Asp Ser Ala His Val Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Xaa Ser Lys Leu Trp Ser Asn Ser His Arg Pro Glu Leu Val Arg 
                85                  90                  95      


Pro Ala Leu Glu Arg Ser Leu Lys Asn Leu Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Leu Ile His Phe Pro Val Ser Val Lys Glu Asp Ile Gly Ile 
        115                 120                 125             


Leu Xaa Trp Lys Lys Ser Pro Lys His Asn Ser 
    130                 135                 


<210> 2150
<211> 200
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<400> 2150
Met Asp Ser Lys Tyr Gln Cys Val Lys Leu Asn Asp Gly His Phe Met 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Xaa Tyr Ala Pro Ala Glu Val Pro Lys Ser 
            20                  25                  30          


Lys Ala Leu Glu Ala Val Lys Leu Ala Ile Glu Ala Gly Phe His His 
        35                  40                  45              


Ile Asp Ser Ala His Val Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Xaa Ser Lys Leu Trp Ser Asn Ser His Arg Pro Glu Leu Val Arg 
                85                  90                  95      


Pro Ala Leu Glu Arg Ser Leu Lys Asn Leu Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Leu Ile His Phe Pro Val Ser Val Lys Pro Gly Glu Glu Val 
        115                 120                 125             


Ile Pro Lys Asp Glu Asn Gly Lys Ile Leu Phe Asp Xaa Val Asp Leu 
    130                 135                 140                 


Cys Ala Xaa Trp Glu Ala Met Glu Lys Cys Lys Asp Ala Gly Leu Ala 
145                 150                 155                 160 


Lys Ser Ile Gly Val Ser Asn Phe Asn His Arg Leu Leu Glu Met Ile 
                165                 170                 175     


Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
            180                 185                 190         


Cys His Pro Tyr Phe Asn Gln Arg 
        195                 200 


<210> 2151
<211> 323
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<400> 2151
Met Asp Ser Lys Tyr Gln Cys Val Lys Leu Asn Asp Gly His Phe Met 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Xaa Tyr Ala Pro Ala Glu Val Pro Lys Ser 
            20                  25                  30          


Lys Ala Leu Glu Ala Val Lys Leu Ala Ile Glu Ala Gly Phe His His 
        35                  40                  45              


Ile Asp Ser Ala His Val Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Xaa Ser Lys Leu Trp Ser Asn Ser His Arg Pro Glu Leu Val Arg 
                85                  90                  95      


Pro Ala Leu Glu Arg Ser Leu Lys Asn Leu Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Leu Ile His Phe Pro Val Ser Val Lys Pro Gly Glu Glu Val 
        115                 120                 125             


Ile Pro Lys Asp Glu Asn Gly Lys Ile Leu Phe Asp Xaa Val Asp Leu 
    130                 135                 140                 


Cys Ala Xaa Trp Glu Ala Met Glu Lys Cys Lys Asp Ala Gly Leu Ala 
145                 150                 155                 160 


Lys Ser Ile Gly Val Ser Asn Phe Asn His Arg Leu Leu Glu Met Ile 
                165                 170                 175     


Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
            180                 185                 190         


Cys His Pro Tyr Phe Asn Gln Arg Lys Leu Leu Asp Phe Cys Lys Ser 
        195                 200                 205             


Lys Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser His Arg Glu 
    210                 215                 220                 


Glu Pro Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val 
225                 230                 235                 240 


Leu Cys Ala Leu Ala Lys Lys His Lys Arg Xaa Pro Ala Leu Ile Ala 
                245                 250                 255     


Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr 
            260                 265                 270         


Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu 
        275                 280                 285             


Xaa Ser Glu Glu Met Lys Ala Ile Asp Gly Leu Asn Arg Asn Val Arg 
    290                 295                 300                 


Tyr Leu Xaa Leu Asp Ile Phe Ala Gly Pro Pro Asn Tyr Pro Phe Ser 
305                 310                 315                 320 


Asp Glu Tyr 
            


<210> 2152
<211> 323
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<400> 2152
Met Asp Ser Lys His Gln Cys Leu Lys Leu Asn Asp Gly His Phe Met 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Xaa Tyr Ala Pro Pro Glu Val Pro Arg Ser 
            20                  25                  30          


Lys Ala Leu Glu Val Xaa Lys Leu Ala Ile Glu Ala Gly Phe Arg His 
        35                  40                  45              


Ile Asp Ser Ala His Leu Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Xaa Ser Lys Leu Trp Ser Xaa Phe His Arg Pro Glu Leu Val Arg 
                85                  90                  95      


Pro Ala Leu Glu Asn Ser Leu Lys Lys Ala Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Leu Ile His Ser Pro Met Ser Leu Lys Pro Gly Glu Glu Leu 
        115                 120                 125             


Ser Pro Xaa Asp Glu Asn Gly Lys Val Ile Phe Asp Ile Val Asp Leu 
    130                 135                 140                 


Cys Xaa Xaa Trp Glu Ala Met Glu Lys Cys Lys Asp Ala Gly Leu Ala 
145                 150                 155                 160 


Lys Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu Met Ile 
                165                 170                 175     


Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
            180                 185                 190         


Cys His Pro Tyr Phe Asn Arg Ser Lys Leu Leu Asp Phe Cys Lys Ser 
        195                 200                 205             


Lys Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser Gln Arg Asp 
    210                 215                 220                 


Lys Arg Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val 
225                 230                 235                 240 


Leu Cys Ala Leu Ala Lys Lys His Lys Arg Xaa Pro Ala Leu Ile Ala 
                245                 250                 255     


Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr 
            260                 265                 270         


Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu 
        275                 280                 285             


Xaa Ala Glu Asp Met Lys Ala Ile Asp Gly Leu Asp Arg Asn Leu His 
    290                 295                 300                 


Tyr Phe Asn Ser Asp Ser Phe Ala Ser His Pro Asn Tyr Pro Tyr Ser 
305                 310                 315                 320 


Asp Glu Tyr 
            


<210> 2153
<211> 323
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<400> 2153
Met Asp Ser Lys His Gln Cys Val Lys Leu Asn Asp Gly His Phe Met 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Xaa Tyr Ala Pro Pro Glu Val Pro Arg Ser 
            20                  25                  30          


Lys Ala Leu Glu Val Xaa Lys Leu Ala Ile Glu Ala Gly Phe Arg His 
        35                  40                  45              


Ile Asp Ser Ala His Leu Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Xaa Ser Lys Leu Trp Ser Xaa Phe His Arg Pro Glu Leu Val Arg 
                85                  90                  95      


Pro Ala Leu Glu Asn Ser Leu Lys Lys Ala Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Leu Ile His Ser Pro Met Ser Leu Lys Pro Gly Glu Glu Leu 
        115                 120                 125             


Ser Pro Xaa Asp Glu Asn Gly Lys Val Ile Phe Asp Ile Val Asp Leu 
    130                 135                 140                 


Cys Xaa Xaa Trp Glu Ala Met Glu Lys Cys Lys Asp Ala Gly Leu Ala 
145                 150                 155                 160 


Lys Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu Met Ile 
                165                 170                 175     


Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
            180                 185                 190         


Cys His Pro Tyr Phe Asn Arg Ser Lys Leu Leu Asp Phe Cys Lys Ser 
        195                 200                 205             


Lys Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser Gln Arg Asp 
    210                 215                 220                 


Lys Arg Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val 
225                 230                 235                 240 


Leu Cys Ala Leu Ala Lys Lys His Lys Arg Xaa Pro Ala Leu Ile Ala 
                245                 250                 255     


Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr 
            260                 265                 270         


Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu 
        275                 280                 285             


Xaa Ala Glu Asp Met Lys Ala Ile Asp Gly Leu Asp Arg Asn Leu His 
    290                 295                 300                 


Tyr Phe Asn Ser Asp Ser Phe Ala Ser His Pro Asn Tyr Pro Tyr Ser 
305                 310                 315                 320 


Asp Glu Tyr 
            


<210> 2154
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(124)
<223> Selenocysteine

<400> 2154
Met Gln Ile Ser Gln Val Pro Arg Ser Lys Ala Leu Glu Val Xaa Lys 
1               5                   10                  15      


Leu Ala Ile Glu Ala Gly Phe Arg His Ile Asp Ser Ala His Leu Tyr 
            20                  25                  30          


Asn Asn Glu Glu Gln Val Gly Leu Ala Ile Arg Ser Lys Ile Ala Asp 
        35                  40                  45              


Gly Ser Val Lys Arg Glu Asp Ile Phe Tyr Xaa Ser Lys Leu Trp Ser 
    50                  55                  60                  


Xaa Phe His Arg Pro Glu Leu Val Arg Pro Ala Leu Glu Asn Ser Leu 
65                  70                  75                  80  


Lys Lys Ala Gln Leu Asp Tyr Val Asp Leu Tyr Leu Ile His Ser Pro 
                85                  90                  95      


Met Ser Leu Lys Pro Gly Glu Glu Leu Ser Pro Xaa Asp Glu Asn Gly 
            100                 105                 110         


Lys Val Ile Phe Asp Ile Val Asp Leu Cys Xaa Xaa Trp Glu Ala Met 
        115                 120                 125             


Glu Lys Cys Lys Asp Ala Gly Leu Ala Lys Ser Ile Gly Val Ser Asn 
    130                 135                 140                 


Phe Asn Arg Arg Gln Leu Glu Met Ile Leu Asn 
145                 150                 155 


<210> 2155
<211> 300
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<400> 2155
Met Gln Ile Ser Gln Val Pro Arg Ser Lys Ala Leu Glu Val Xaa Lys 
1               5                   10                  15      


Leu Ala Ile Glu Ala Gly Phe Arg His Ile Asp Ser Ala His Leu Tyr 
            20                  25                  30          


Asn Asn Glu Glu Gln Val Gly Leu Ala Ile Arg Ser Lys Ile Ala Asp 
        35                  40                  45              


Gly Ser Val Lys Arg Glu Asp Ile Phe Tyr Xaa Ser Lys Leu Trp Ser 
    50                  55                  60                  


Xaa Phe His Arg Pro Glu Leu Val Arg Pro Ala Leu Glu Asn Ser Leu 
65                  70                  75                  80  


Lys Lys Ala Gln Leu Asp Tyr Val Asp Leu Tyr Leu Ile His Ser Pro 
                85                  90                  95      


Met Ser Leu Lys Pro Gly Glu Glu Leu Ser Pro Xaa Asp Glu Asn Gly 
            100                 105                 110         


Lys Val Ile Phe Asp Ile Val Asp Leu Cys Xaa Xaa Trp Glu Ala Met 
        115                 120                 125             


Glu Lys Cys Lys Asp Ala Gly Leu Ala Lys Ser Ile Gly Val Ser Asn 
    130                 135                 140                 


Phe Asn Arg Arg Gln Leu Glu Met Ile Leu Asn Lys Pro Gly Leu Lys 
145                 150                 155                 160 


Tyr Lys Pro Val Cys Asn Gln Val Glu Cys His Pro Tyr Phe Asn Arg 
                165                 170                 175     


Ser Lys Leu Leu Asp Phe Cys Lys Ser Lys Asp Ile Val Leu Val Ala 
            180                 185                 190         


Tyr Ser Ala Leu Gly Ser Gln Arg Asp Lys Arg Trp Val Asp Pro Asn 
        195                 200                 205             


Ser Pro Val Leu Leu Glu Asp Pro Val Leu Cys Ala Leu Ala Lys Lys 
    210                 215                 220                 


His Lys Arg Xaa Pro Ala Leu Ile Ala Leu Arg Tyr Gln Leu Gln Arg 
225                 230                 235                 240 


Gly Val Val Val Leu Ala Lys Ser Tyr Asn Glu Gln Arg Ile Arg Gln 
                245                 250                 255     


Asn Val Gln Val Phe Glu Phe Gln Leu Xaa Ala Glu Asp Met Lys Ala 
            260                 265                 270         


Ile Asp Gly Leu Asp Arg Asn Leu His Tyr Phe Asn Ser Asp Ser Phe 
        275                 280                 285             


Ala Ser His Pro Asn Tyr Pro Tyr Ser Asp Glu Tyr 
    290                 295                 300 


<210> 2156
<211> 146
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 2156
Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile Lys Ile Xaa Asp 
1               5                   10                  15      


Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala Xaa Met Lys Xaa 
            20                  25                  30          


Phe Cys Gly Xaa Pro Glu Tyr Leu Ala Pro Glu Val Leu Glu Asp Asn 
        35                  40                  45              


Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly Val Val Met Tyr 
    50                  55                  60                  


Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln Asp His Glu Lys 
65                  70                  75                  80  


Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe Pro Arg Xaa Leu 
                85                  90                  95      


Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu Lys Lys Asp Pro 
            100                 105                 110         


Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys Glu Ile Met Gln 
        115                 120                 125             


His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val Tyr Glu Lys Lys 
    130                 135                 140                 


Gly Pro 
145     


<210> 2157
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 2157
Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Xaa Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30          


Gly Xaa Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45              


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60                  


Xaa Glu Arg Pro Arg Pro Asn Xaa Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Xaa Xaa Val Ile Glu Arg Xaa Phe His Val Glu Xaa 
                85                  90          


<210> 2158
<211> 480
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<400> 2158
Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Xaa Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30          


Gly Xaa Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45              


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60                  


Xaa Glu Arg Pro Arg Pro Asn Xaa Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Xaa Xaa Val Ile Glu Arg Xaa Phe His Val Glu Xaa Pro Glu Glu Arg 
                85                  90                  95      


Glu Glu Trp Xaa Xaa Ala Ile Gln Xaa Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110         


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125             


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140                 


Val Xaa Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Xaa 
145                 150                 155                 160 


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Xaa Gly Arg Tyr Tyr 
                165                 170                 175     


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190         


Ala His Xaa Leu Xaa Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205             


Phe Leu Xaa Ala Leu Lys Tyr Ser Phe Gln Xaa His Asp Arg Leu Cys 
    210                 215                 220                 


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240 


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255     


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270         


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285             


Lys Ile Xaa Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300                 


Xaa Met Lys Xaa Phe Cys Gly Xaa Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320 


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335     


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350         


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365             


Pro Arg Xaa Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380                 


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400 


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415     


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Xaa Ser Glu 
            420                 425                 430         


Xaa Asp Xaa Arg Tyr Phe Asp Glu Glu Phe Xaa Ala Gln Met Ile Xaa 
        435                 440                 445             


Ile Xaa Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460                 


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Xaa Ala 
465                 470                 475                 480 


<210> 2159
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<400> 2159
Xaa Gly Ile Lys Asp Gly Ala Xaa Met Lys Xaa Phe Cys Gly Xaa Pro 
1               5                   10                  15      


Glu Tyr Leu Ala Pro Glu Val Leu Glu Asp Asn Asp Tyr Gly Arg Ala 
            20                  25                  30          


Val Asp Trp Trp Gly Leu Gly Val Val Met Tyr Glu Met Met Cys Gly 
        35                  40                  45              


Arg Leu Pro Phe Tyr Asn Gln Asp His Glu Lys Leu Phe Glu Leu Ile 
    50                  55                  60                  


Leu Met Glu Glu Ile Arg Phe Pro Arg Xaa Leu Gly Pro Glu Ala Lys 
65                  70                  75                  80  


Ser Leu Leu Ser Gly Leu Leu Lys Lys Asp Pro Lys Gln Arg Leu Gly 
                85                  90                  95      


Gly Gly Ser Glu Asp Ala Lys Glu Ile Met Gln His Arg Phe Phe Ala 
            100                 105                 110         


Gly Ile Val Trp Gln His Val Tyr Glu Lys Lys Leu Ser Pro Pro Phe 
        115                 120                 125             


Lys Pro Gln Val Xaa Ser Glu Xaa Asp Xaa Arg Tyr Phe Asp Glu Glu 
    130                 135                 140                 


Phe Xaa Ala Gln Met Ile Xaa Ile Xaa Pro Pro Asp Gln Val Leu Gly 
145                 150                 155                 160 


Asp Cys Pro Xaa Gly Ser Leu Pro Leu Arg 
                165                 170 


<210> 2160
<211> 184
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<400> 2160
Xaa His Ser Glu Lys Asn Val Val Tyr Arg Asp Leu Lys Leu Glu Asn 
1               5                   10                  15      


Leu Met Leu Asp Lys Asp Gly His Ile Lys Ile Xaa Asp Phe Gly Leu 
            20                  25                  30          


Cys Lys Glu Gly Ile Lys Asp Gly Ala Xaa Met Lys Xaa Phe Cys Gly 
        35                  40                  45              


Xaa Pro Glu Tyr Leu Ala Pro Glu Asp His Glu Lys Leu Phe Glu Leu 
    50                  55                  60                  


Ile Leu Met Glu Glu Ile Arg Phe Pro Arg Xaa Leu Gly Pro Glu Ala 
65                  70                  75                  80  


Lys Ser Leu Leu Ser Gly Leu Leu Lys Lys Asp Pro Lys Gln Arg Leu 
                85                  90                  95      


Gly Gly Gly Ser Glu Asp Ala Lys Glu Ile Met Gln His Arg Phe Phe 
            100                 105                 110         


Ala Gly Ile Val Trp Gln His Val Tyr Glu Lys Lys Leu Ser Pro Pro 
        115                 120                 125             


Phe Lys Pro Gln Val Xaa Ser Glu Xaa Asp Xaa Arg Tyr Phe Asp Glu 
    130                 135                 140                 


Glu Phe Xaa Ala Gln Met Ile Xaa Ile Xaa Pro Pro Asp Gln Asp Asp 
145                 150                 155                 160 


Ser Met Glu Cys Val Asp Ser Glu Arg Arg Pro His Phe Pro Gln Phe 
                165                 170                 175     


Ser Tyr Ser Ala Ser Gly Xaa Ala 
            180                 


<210> 2161
<211> 33
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<400> 2161
Met Ala Ser Gly Arg Pro Glu Glu Leu Trp Glu Ala Val Val Gly Ala 
1               5                   10                  15      


Ala Glu Arg Phe Arg Ala Arg Xaa Gly Xaa Glu Leu Val Leu Leu Xaa 
            20                  25                  30          


Ala 
    


<210> 2162
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<400> 2162
Met Ala Ser Gly Arg Pro Glu Glu Leu Trp Glu Ala Val Val Gly Ala 
1               5                   10                  15      


Ala Glu Arg Phe Arg Ala Arg Xaa Gly Xaa Glu Leu Val Leu Leu Xaa 
            20                  25                  30          


Ala Ala Pro Pro Pro Pro Pro Arg Pro Gly Pro Cys Ala Tyr Ala Ala 
        35                  40                  45              


His Gly Arg Gly Ala Leu Ala Glu Ala Ala Arg Arg Cys Leu His Asp 
    50                  55                  60                  


Ile Ala Leu Ala His Arg Ala Ala Xaa Ala Ala Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Gln Pro Pro Ser Pro Xaa Pro Ser Pro Pro Arg Pro 
                85                  90                  95      


Xaa Leu Ala Arg Glu Asp Asn Glu Glu Asp Glu Asp 
            100                 105             


<210> 2163
<211> 256
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<400> 2163
Met Ala Ser Gly Arg Pro Glu Glu Leu Trp Glu Ala Val Val Gly Ala 
1               5                   10                  15      


Ala Glu Arg Phe Arg Ala Arg Xaa Gly Xaa Glu Leu Val Leu Leu Xaa 
            20                  25                  30          


Ala Ala Pro Pro Pro Pro Pro Arg Pro Gly Pro Cys Ala Tyr Ala Ala 
        35                  40                  45              


His Gly Arg Gly Ala Leu Ala Glu Ala Ala Arg Arg Cys Leu His Asp 
    50                  55                  60                  


Ile Ala Leu Ala His Arg Ala Ala Xaa Ala Ala Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Gln Pro Pro Ser Pro Xaa Pro Ser Pro Pro Arg Pro 
                85                  90                  95      


Xaa Leu Ala Arg Glu Asp Asn Glu Glu Asp Glu Asp Glu Pro Xaa Glu 
            100                 105                 110         


Xaa Glu Xaa Ser Gly Glu Gln Leu Gly Ile Ser Asp Asn Gly Gly Leu 
        115                 120                 125             


Phe Val Met Asp Glu Asp Ala Xaa Leu Gln Asp Leu Pro Pro Phe Cys 
    130                 135                 140                 


Glu Ser Asp Pro Glu Ser Xaa Asp Asp Gly Ser Leu Ser Glu Glu Xaa 
145                 150                 155                 160 


Pro Ala Gly Pro Pro Xaa Cys Ser Val Pro Pro Ala Ser Ala Leu Pro 
                165                 170                 175     


Xaa Gln Gln Tyr Ala Lys Ser Leu Pro Val Ser Val Pro Val Trp Gly 
            180                 185                 190         


Phe Lys Glu Lys Arg Xaa Glu Ala Arg Ser Ser Asp Glu Glu Asn Gly 
        195                 200                 205             


Pro Pro Ser Ser Pro Asp Leu Asp Arg Ile Ala Ala Ser Met Arg Ala 
    210                 215                 220                 


Leu Val Leu Arg Glu Ala Glu Asp Xaa Gln Val Phe Gly Asp Leu Pro 
225                 230                 235                 240 


Arg Pro Arg Leu Asn Xaa Ser Asp Phe Gln Lys Leu Lys Arg Lys Tyr 
                245                 250                 255     


<210> 2164
<211> 276
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<400> 2164
Met Ser Phe Glu Gly Gly Asp Gly Ala Gly Pro Ala Met Leu Ala Xaa 
1               5                   10                  15      


Gly Xaa Ala Arg Met Ala Ser Gly Arg Pro Glu Glu Leu Trp Glu Ala 
            20                  25                  30          


Val Val Gly Ala Ala Glu Arg Phe Arg Ala Arg Xaa Gly Xaa Glu Leu 
        35                  40                  45              


Val Leu Leu Xaa Ala Ala Pro Pro Pro Pro Pro Arg Pro Gly Pro Cys 
    50                  55                  60                  


Ala Tyr Ala Ala His Gly Arg Gly Ala Leu Ala Glu Ala Ala Arg Arg 
65                  70                  75                  80  


Cys Leu His Asp Ile Ala Leu Ala His Arg Ala Ala Xaa Ala Ala Arg 
                85                  90                  95      


Pro Pro Ala Pro Pro Pro Ala Pro Gln Pro Pro Ser Pro Xaa Pro Ser 
            100                 105                 110         


Pro Pro Arg Pro Xaa Leu Ala Arg Glu Asp Asn Glu Glu Asp Glu Asp 
        115                 120                 125             


Glu Pro Xaa Glu Xaa Glu Xaa Ser Gly Glu Gln Leu Gly Ile Ser Asp 
    130                 135                 140                 


Asn Gly Gly Leu Phe Val Met Asp Glu Asp Ala Xaa Leu Gln Asp Leu 
145                 150                 155                 160 


Pro Pro Phe Cys Glu Ser Asp Pro Glu Ser Xaa Asp Asp Gly Ser Leu 
                165                 170                 175     


Ser Glu Glu Xaa Pro Ala Gly Pro Pro Xaa Cys Ser Val Pro Pro Ala 
            180                 185                 190         


Ser Ala Leu Pro Xaa Gln Gln Tyr Ala Lys Ser Leu Pro Val Ser Val 
        195                 200                 205             


Pro Val Trp Gly Phe Lys Glu Lys Arg Xaa Glu Ala Arg Ser Ser Asp 
    210                 215                 220                 


Glu Glu Asn Gly Pro Pro Ser Ser Pro Asp Leu Asp Arg Ile Ala Ala 
225                 230                 235                 240 


Ser Met Arg Ala Leu Val Leu Arg Glu Ala Glu Asp Xaa Gln Val Phe 
                245                 250                 255     


Gly Asp Leu Pro Arg Pro Arg Leu Asn Xaa Ser Asp Phe Gln Lys Leu 
            260                 265                 270         


Lys Arg Lys Tyr 
        275     


<210> 2165
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<400> 2165
Asp Trp Trp Gly Leu Gly Val Val Met Tyr Glu Met Met Cys Gly Arg 
1               5                   10                  15      


Leu Pro Phe Tyr Asn Gln Asp His Glu Arg Leu Phe Glu Leu Ile Leu 
            20                  25                  30          


Met Glu Glu Ile Arg Phe Pro Arg Xaa Leu Ser Pro Glu Ala Lys Ser 
        35                  40                  45              


Leu Leu Ala Gly Leu Leu Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly 
    50                  55                  60                  


Gly Pro Ser Asp Ala Lys Glu Val Met Glu His Arg Phe Phe Leu Ser 
65                  70                  75                  80  


Ile Asn Trp Gln Asp Val Val Gln Lys Lys Leu Leu Pro Pro Phe Lys 
                85                  90                  95      


Pro Gln Val Xaa Ser Glu Val Asp Xaa Arg 
            100                 105     


<210> 2166
<211> 292
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<400> 2166
Lys Cys Gly Ser Pro Ser Asp Ser Ser Xaa Xaa Glu Glu Met Glu Val 
1               5                   10                  15      


Ala Val Ser Lys Ala Arg Ala Lys Val Xaa Met Asn Asp Phe Asp Tyr 
            20                  25                  30          


Leu Lys Leu Leu Gly Lys Gly Xaa Phe Gly Lys Val Ile Leu Val Arg 
        35                  40                  45              


Glu Lys Ala Xaa Gly Arg Tyr Tyr Ala Met Lys Ile Leu Arg Lys Glu 
    50                  55                  60                  


Val Ile Ile Ala Lys Ala Leu Lys Tyr Ala Phe Gln Xaa His Asp Arg 
65                  70                  75                  80  


Leu Cys Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His 
                85                  90                  95      


Leu Ser Arg Glu Arg Val Phe Xaa Glu Glu Arg Ala Arg Phe Tyr Gly 
            100                 105                 110         


Ala Glu Ile Val Ser Ala Leu Glu Tyr Leu His Ser Arg Asp Val Val 
        115                 120                 125             


Tyr Arg Asp Ile Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His 
    130                 135                 140                 


Ile Lys Ile Xaa Asp Phe Gly Leu Cys Lys Glu Gly Ile Ser Asp Gly 
145                 150                 155                 160 


Ala Xaa Met Lys Xaa Phe Cys Gly Xaa Pro Glu Tyr Leu Ala Pro Glu 
                165                 170                 175     


Val Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu 
            180                 185                 190         


Gly Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn 
        195                 200                 205             


Gln Asp His Glu Arg Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg 
    210                 215                 220                 


Phe Pro Arg Xaa Leu Ser Pro Glu Ala Lys Ser Leu Leu Ala Gly Leu 
225                 230                 235                 240 


Leu Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Pro Ser Asp Ala 
                245                 250                 255     


Lys Glu Val Met Glu His Arg Phe Phe Leu Ser Ile Asn Trp Gln Asp 
            260                 265                 270         


Val Val Gln Lys Lys Leu Leu Pro Pro Phe Lys Pro Gln Val Xaa Ser 
        275                 280                 285             


Glu Val Asp Xaa 
    290         


<210> 2167
<211> 450
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<400> 2167
Met Lys Xaa Glu Arg Pro Arg Pro Asn Xaa Phe Val Ile Arg Cys Leu 
1               5                   10                  15      


Gln Trp Xaa Xaa Val Ile Glu Arg Xaa Phe His Val Asp Ser Pro Asp 
            20                  25                  30          


Glu Arg Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu 
        35                  40                  45              


Lys Gln Arg Ala Pro Gly Glu Asp Pro Met Asp Tyr Lys Cys Gly Ser 
    50                  55                  60                  


Pro Ser Asp Ser Ser Xaa Xaa Glu Glu Met Glu Val Ala Val Ser Lys 
65                  70                  75                  80  


Ala Arg Ala Lys Val Xaa Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu 
                85                  90                  95      


Gly Lys Gly Xaa Phe Gly Lys Val Ile Leu Val Arg Glu Lys Ala Xaa 
            100                 105                 110         


Gly Arg Tyr Tyr Ala Met Lys Ile Leu Arg Lys Glu Val Ile Ile Ala 
        115                 120                 125             


Lys Asp Glu Val Ala His Xaa Val Xaa Glu Ser Arg Val Leu Gln Asn 
    130                 135                 140                 


Xaa Arg His Pro Phe Leu Xaa Ala Leu Lys Tyr Ala Phe Gln Xaa His 
145                 150                 155                 160 


Asp Arg Leu Cys Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe 
                165                 170                 175     


Phe His Leu Ser Arg Glu Arg Val Phe Xaa Glu Glu Arg Ala Arg Phe 
            180                 185                 190         


Tyr Gly Ala Glu Ile Val Ser Ala Leu Glu Tyr Leu His Ser Arg Asp 
        195                 200                 205             


Val Val Tyr Arg Asp Ile Lys Leu Glu Asn Leu Met Leu Asp Lys Asp 
    210                 215                 220                 


Gly His Ile Lys Ile Xaa Asp Phe Gly Leu Cys Lys Glu Gly Ile Ser 
225                 230                 235                 240 


Asp Gly Ala Xaa Met Lys Xaa Phe Cys Gly Xaa Pro Glu Tyr Leu Ala 
                245                 250                 255     


Pro Glu Val Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp 
            260                 265                 270         


Gly Leu Gly Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe 
        275                 280                 285             


Tyr Asn Gln Asp His Glu Arg Leu Phe Glu Leu Ile Leu Met Glu Glu 
    290                 295                 300                 


Ile Arg Phe Pro Arg Xaa Leu Ser Pro Glu Ala Lys Ser Leu Leu Ala 
305                 310                 315                 320 


Gly Leu Leu Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Pro Ser 
                325                 330                 335     


Asp Ala Lys Glu Val Met Glu His Arg Phe Phe Leu Ser Ile Asn Trp 
            340                 345                 350         


Gln Asp Val Val Gln Lys Lys Leu Leu Pro Pro Phe Lys Pro Gln Val 
        355                 360                 365             


Xaa Ser Glu Val Asp Xaa Arg Tyr Phe Asp Asp Glu Phe Xaa Ala Gln 
    370                 375                 380                 


Ser Ile Xaa Ile Xaa Pro Pro Asp Arg Cys Glu Cys Leu Gly Pro Pro 
385                 390                 395                 400 


Arg Trp Cys Ala Cys Pro Arg Gly Gly Gly Met Gly Ser Ala Leu Asn 
                405                 410                 415     


Ser Leu Leu Lys Glu Gly Pro Arg Arg Pro Pro Leu His Val Trp Glu 
            420                 425                 430         


Ile Ser Pro Ser Leu Leu Ser Gly Pro Phe Ala Val Gly Pro Leu Trp 
        435                 440                 445             


Xaa Trp 
    450 


<210> 2168
<211> 126
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<400> 2168
Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Xaa Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Xaa 
        35                  40                  45              


Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Ala Pro Cys Cys Leu Phe 
    50                  55                  60                  


Pro Leu Pro Ala Glu Cys Gln Leu Met Lys Xaa Glu Arg Pro Arg Pro 
65                  70                  75                  80  


Asn Xaa Phe Val Ile Arg Cys Leu Gln Trp Xaa Xaa Val Ile Glu Arg 
                85                  90                  95      


Xaa Phe His Val Asp Ser Pro Asp Glu Arg Glu Glu Trp Met Arg Ala 
            100                 105                 110         


Ile Gln Met Val Ala Asn Ser Leu Lys Gln Arg Ala Pro Gly 
        115                 120                 125     


<210> 2169
<211> 67
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<400> 2169
Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Xaa Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Xaa 
        35                  40                  45              


Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 
    50                  55                  60                  


Xaa Glu Arg 
65          


<210> 2170
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<400> 2170
Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Xaa Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Xaa 
        35                  40                  45              


Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 
    50                  55                  60                  


Xaa Glu Arg Pro Arg Pro Asn Xaa Phe Val Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Xaa Xaa Val Ile Glu Arg Xaa Phe His Val Asp Ser Pro Asp Glu 
                85                  90                  95  


<210> 2171
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<400> 2171
Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Xaa Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Xaa 
        35                  40                  45              


Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 
    50                  55                  60                  


Xaa Glu Arg Pro Arg Pro Asn Xaa Phe Val Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Xaa Xaa Val Ile Glu Arg Xaa Phe His Val Asp Ser Pro Asp Glu Arg 
                85                  90                  95      


Glu Glu Trp 
            


<210> 2172
<211> 107
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<400> 2172
Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Xaa Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Xaa 
        35                  40                  45              


Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 
    50                  55                  60                  


Xaa Glu Arg Pro Arg Pro Asn Xaa Phe Val Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Xaa Xaa Val Ile Glu Arg Xaa Phe His Val Asp Ser Pro Asp Glu Arg 
                85                  90                  95      


Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala 
            100                 105         


<210> 2173
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<400> 2173
Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Xaa Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Xaa 
        35                  40                  45              


Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 
    50                  55                  60                  


Xaa Glu Arg Pro Arg Pro Asn Xaa Phe Val Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Xaa Xaa Val Ile Glu Arg Xaa Phe His Val Asp Ser Pro Asp Glu Arg 
                85                  90                  95      


Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu Lys Gln 
            100                 105                 110         


Arg Ala Pro Gly Glu Asp Pro 
        115                 


<210> 2174
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<400> 2174
Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Xaa Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Xaa 
        35                  40                  45              


Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 
    50                  55                  60                  


Xaa Glu Arg Pro Arg Pro Asn Xaa Phe Val Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Xaa Xaa Val Ile Glu Arg Xaa Phe His Val Asp Ser Pro Asp Glu Arg 
                85                  90                  95      


Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu Lys Gln 
            100                 105                 110         


Arg Ala Pro Gly Glu Asp Pro Met Asp Tyr Lys Cys Gly Ser Pro Ser 
        115                 120                 125             


Asp Ser 
    130 


<210> 2175
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(133)
<223> Selenocysteine

<400> 2175
Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Xaa Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Xaa 
        35                  40                  45              


Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 
    50                  55                  60                  


Xaa Glu Arg Pro Arg Pro Asn Xaa Phe Val Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Xaa Xaa Val Ile Glu Arg Xaa Phe His Val Asp Ser Pro Asp Glu Arg 
                85                  90                  95      


Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu Lys Gln 
            100                 105                 110         


Arg Ala Pro Gly Glu Asp Pro Met Asp Tyr Lys Cys Gly Ser Pro Ser 
        115                 120                 125             


Asp Ser Ser Xaa Xaa 
    130             


<210> 2176
<211> 134
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(133)
<223> Selenocysteine

<400> 2176
Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Xaa Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Xaa 
        35                  40                  45              


Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 
    50                  55                  60                  


Xaa Glu Arg Pro Arg Pro Asn Xaa Phe Val Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Xaa Xaa Val Ile Glu Arg Xaa Phe His Val Asp Ser Pro Asp Glu Arg 
                85                  90                  95      


Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu Lys Gln 
            100                 105                 110         


Arg Ala Pro Gly Glu Asp Pro Met Asp Tyr Lys Cys Gly Ser Pro Ser 
        115                 120                 125             


Asp Ser Ser Xaa Xaa Glu 
    130                 


<210> 2177
<211> 151
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 2177
Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Xaa Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Xaa 
        35                  40                  45              


Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 
    50                  55                  60                  


Xaa Glu Arg Pro Arg Pro Asn Xaa Phe Val Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Xaa Xaa Val Ile Glu Arg Xaa Phe His Val Asp Ser Pro Asp Glu Arg 
                85                  90                  95      


Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu Lys Gln 
            100                 105                 110         


Arg Ala Pro Gly Glu Asp Pro Met Asp Tyr Lys Cys Gly Ser Pro Ser 
        115                 120                 125             


Asp Ser Ser Xaa Xaa Glu Glu Met Glu Val Ala Val Ser Lys Ala Arg 
    130                 135                 140                 


Ala Lys Val Xaa Met Asn Asp 
145                 150     


<210> 2178
<211> 157
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 2178
Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Xaa Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Xaa 
        35                  40                  45              


Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 
    50                  55                  60                  


Xaa Glu Arg Pro Arg Pro Asn Xaa Phe Val Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Xaa Xaa Val Ile Glu Arg Xaa Phe His Val Asp Ser Pro Asp Glu Arg 
                85                  90                  95      


Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu Lys Gln 
            100                 105                 110         


Arg Ala Pro Gly Glu Asp Pro Met Asp Tyr Lys Cys Gly Ser Pro Ser 
        115                 120                 125             


Asp Ser Ser Xaa Xaa Glu Glu Met Glu Val Ala Val Ser Lys Ala Arg 
    130                 135                 140                 


Ala Lys Val Xaa Met Asn Asp Phe Asp Tyr Leu Lys Leu 
145                 150                 155         


<210> 2179
<211> 184
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<400> 2179
Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Xaa Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Xaa 
        35                  40                  45              


Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 
    50                  55                  60                  


Xaa Glu Arg Pro Arg Pro Asn Xaa Phe Val Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Xaa Xaa Val Ile Glu Arg Xaa Phe His Val Asp Ser Pro Asp Glu Arg 
                85                  90                  95      


Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu Lys Gln 
            100                 105                 110         


Arg Ala Pro Gly Glu Asp Pro Met Asp Tyr Lys Cys Gly Ser Pro Ser 
        115                 120                 125             


Asp Ser Ser Xaa Xaa Glu Glu Met Glu Val Ala Val Ser Lys Ala Arg 
    130                 135                 140                 


Ala Lys Val Xaa Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys 
145                 150                 155                 160 


Gly Xaa Phe Gly Lys Val Ile Leu Val Arg Glu Lys Ala Xaa Gly Arg 
                165                 170                 175     


Tyr Tyr Ala Met Lys Ile Leu Arg 
            180                 


<210> 2180
<211> 438
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<400> 2180
Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Xaa Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Xaa 
        35                  40                  45              


Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 
    50                  55                  60                  


Xaa Glu Arg Pro Arg Pro Asn Xaa Phe Val Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Xaa Xaa Val Ile Glu Arg Xaa Phe His Val Asp Ser Pro Asp Glu Arg 
                85                  90                  95      


Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu Lys Gln 
            100                 105                 110         


Arg Ala Pro Gly Glu Asp Pro Met Asp Tyr Lys Cys Gly Ser Pro Ser 
        115                 120                 125             


Asp Ser Ser Xaa Xaa Glu Glu Met Glu Val Ala Val Ser Lys Ala Arg 
    130                 135                 140                 


Ala Lys Val Xaa Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys 
145                 150                 155                 160 


Gly Xaa Phe Gly Lys Val Ile Leu Val Arg Glu Lys Ala Xaa Gly Arg 
                165                 170                 175     


Tyr Tyr Ala Met Lys Ile Leu Arg Lys Glu Val Ile Ile Ala Lys Asp 
            180                 185                 190         


Glu Val Ala His Xaa Val Xaa Glu Ser Arg Val Leu Gln Asn Xaa Arg 
        195                 200                 205             


His Pro Phe Leu Xaa Ala Leu Lys Tyr Ala Phe Gln Xaa His Asp Arg 
    210                 215                 220                 


Leu Cys Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His 
225                 230                 235                 240 


Leu Ser Arg Glu Arg Val Phe Xaa Glu Glu Arg Ala Arg Phe Tyr Gly 
                245                 250                 255     


Ala Glu Ile Val Ser Ala Leu Glu Tyr Leu His Ser Arg Asp Val Val 
            260                 265                 270         


Tyr Arg Asp Ile Lys Val Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val 
        275                 280                 285             


Asp Trp Trp Gly Leu Gly Val Val Met Tyr Glu Met Met Cys Gly Arg 
    290                 295                 300                 


Leu Pro Phe Tyr Asn Gln Asp His Glu Arg Leu Phe Glu Leu Ile Leu 
305                 310                 315                 320 


Met Glu Glu Ile Arg Phe Pro Arg Xaa Leu Ser Pro Glu Ala Lys Ser 
                325                 330                 335     


Leu Leu Ala Gly Leu Leu Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly 
            340                 345                 350         


Gly Pro Ser Asp Ala Lys Glu Val Met Glu His Arg Phe Phe Leu Ser 
        355                 360                 365             


Ile Asn Trp Gln Asp Val Val Gln Lys Lys Leu Leu Pro Pro Phe Lys 
    370                 375                 380                 


Pro Gln Val Xaa Ser Glu Val Asp Xaa Arg Tyr Phe Asp Asp Glu Phe 
385                 390                 395                 400 


Xaa Ala Gln Ser Ile Xaa Ile Xaa Pro Pro Asp Arg Tyr Asp Ser Leu 
                405                 410                 415     


Gly Leu Leu Glu Leu Asp Gln Arg Xaa His Phe Pro Gln Phe Ser Tyr 
            420                 425                 430         


Ser Ala Ser Ile Arg Glu 
        435             


<210> 2181
<211> 481
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<400> 2181
Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Xaa Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Xaa 
        35                  40                  45              


Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys 
    50                  55                  60                  


Xaa Glu Arg Pro Arg Pro Asn Xaa Phe Val Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Xaa Xaa Val Ile Glu Arg Xaa Phe His Val Asp Ser Pro Asp Glu Arg 
                85                  90                  95      


Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu Lys Gln 
            100                 105                 110         


Arg Ala Pro Gly Glu Asp Pro Met Asp Tyr Lys Cys Gly Ser Pro Ser 
        115                 120                 125             


Asp Ser Ser Xaa Xaa Glu Glu Met Glu Val Ala Val Ser Lys Ala Arg 
    130                 135                 140                 


Ala Lys Val Xaa Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys 
145                 150                 155                 160 


Gly Xaa Phe Gly Lys Val Ile Leu Val Arg Glu Lys Ala Xaa Gly Arg 
                165                 170                 175     


Tyr Tyr Ala Met Lys Ile Leu Arg Lys Glu Val Ile Ile Ala Lys Asp 
            180                 185                 190         


Glu Val Ala His Xaa Val Xaa Glu Ser Arg Val Leu Gln Asn Xaa Arg 
        195                 200                 205             


His Pro Phe Leu Xaa Ala Leu Lys Tyr Ala Phe Gln Xaa His Asp Arg 
    210                 215                 220                 


Leu Cys Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His 
225                 230                 235                 240 


Leu Ser Arg Glu Arg Val Phe Xaa Glu Glu Arg Ala Arg Phe Tyr Gly 
                245                 250                 255     


Ala Glu Ile Val Ser Ala Leu Glu Tyr Leu His Ser Arg Asp Val Val 
            260                 265                 270         


Tyr Arg Asp Ile Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His 
        275                 280                 285             


Ile Lys Ile Xaa Asp Phe Gly Leu Cys Lys Glu Gly Ile Ser Asp Gly 
    290                 295                 300                 


Ala Xaa Met Lys Xaa Phe Cys Gly Xaa Pro Glu Tyr Leu Ala Pro Glu 
305                 310                 315                 320 


Val Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu 
                325                 330                 335     


Gly Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn 
            340                 345                 350         


Gln Asp His Glu Arg Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg 
        355                 360                 365             


Phe Pro Arg Xaa Leu Ser Pro Glu Ala Lys Ser Leu Leu Ala Gly Leu 
    370                 375                 380                 


Leu Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Pro Ser Asp Ala 
385                 390                 395                 400 


Lys Glu Val Met Glu His Arg Phe Phe Leu Ser Ile Asn Trp Gln Asp 
                405                 410                 415     


Val Val Gln Lys Lys Leu Leu Pro Pro Phe Lys Pro Gln Val Xaa Ser 
            420                 425                 430         


Glu Val Asp Xaa Arg Tyr Phe Asp Asp Glu Phe Xaa Ala Gln Ser Ile 
        435                 440                 445             


Xaa Ile Xaa Pro Pro Asp Arg Tyr Asp Ser Leu Gly Leu Leu Glu Leu 
    450                 455                 460                 


Asp Gln Arg Xaa His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Ile Arg 
465                 470                 475                 480 


Glu 
    


<210> 2182
<211> 69
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<400> 2182
Met Pro Ala Asp Glu Asp Arg Glu Ala Ala Xaa Gln His Leu Cys His 
1               5                   10                  15      


Xaa Leu Pro Ala Val Asp His Ser His Arg Glu Asp Leu Pro Arg Gly 
            20                  25                  30          


Phe Ser Arg Arg Glu Gly Gly Val Asp Ala Gly His Pro Asp Gly Arg 
        35                  40                  45              


Gln Gln Pro Gln Ala Ala Gly Pro Arg Arg Gly Pro His Gly Leu Gln 
    50                  55                  60                  


Val Trp Leu Pro Gln 
65                  


<210> 2183
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<400> 2183
Val Asp Ser Pro Asp Glu Arg Glu Glu Trp Met Arg Ala Ile Gln Met 
1               5                   10                  15      


Val Ala Asn Ser Leu Lys Gln Arg Ala Pro Gly Glu Asp Pro Met Asp 
            20                  25                  30          


Tyr Lys Cys Gly Ser Pro Ser Asp Ser Ser Xaa Xaa Glu Glu Met Glu 
        35                  40                  45              


Val Ala Val Ser Lys Ala Arg Ala Lys Val Xaa Met Asn Asp Phe Asp 
    50                  55                  60                  


Tyr Leu Lys Leu Leu Gly Lys Gly Xaa Phe Gly Lys Val Ile Leu Val 
65                  70                  75                  80  


Arg Glu Lys Ala Xaa Gly Arg Tyr Tyr Ala Met Lys Ile Leu Arg Lys 
                85                  90                  95      


Glu Val Ile Ile Ala Lys Ser Val Cys Arg Met Lys Ser Leu Xaa Gln 
            100                 105                 110         


Ser Pro Arg Ala Gly Ser Ser Arg Xaa Pro Gly Xaa Arg Ser Ser Leu 
        115                 120                 125             


Arg 
    


<210> 2184
<211> 56
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<400> 2184
Xaa Gly Arg Leu Pro Phe Tyr Asn Gln Asp His Glu Arg Leu Phe Glu 
1               5                   10                  15      


Leu Ile Leu Met Glu Glu Ile Arg Phe Pro Arg Xaa Leu Ser Pro Glu 
            20                  25                  30          


Ala Lys Ser Leu Leu Ala Gly Leu Leu Lys Lys Asp Pro Lys Gln Ser 
        35                  40                  45              


Gly Leu Trp Ser Arg Gln Asn His 
    50                  55      


<210> 2185
<211> 53
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<400> 2185
Xaa Leu Val Arg Glu Lys Ala Xaa Gly Arg Tyr Tyr Ala Met Lys Ile 
1               5                   10                  15      


Leu Arg Lys Glu Val Ile Ile Ala Lys Leu Glu Asn Leu Met Leu Asp 
            20                  25                  30          


Lys Asp Gly His Ile Lys Ile Xaa Asp Phe Gly Leu Cys Lys Glu Gly 
        35                  40                  45              


Ile Ser Asp Gly Ala 
    50              


<210> 2186
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<400> 2186
Xaa Pro Arg Xaa Leu Ser Pro Glu Ala Lys Ser Leu Leu Ala Gly Leu 
1               5                   10                  15      


Leu Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Pro Ser Asp Ala 
            20                  25                  30          


Lys Glu Val Met Glu His Arg Phe Phe Leu Ser Ile Asn Trp Gln Asp 
        35                  40                  45              


Val Val Gln Lys Lys Leu Leu Pro Pro Phe Lys Pro Gln Val Xaa Ser 
    50                  55                  60                  


Glu Val Asp Xaa Arg Tyr Phe Asp Asp Glu Phe Xaa Ala Gln Ser Ile 
65                  70                  75                  80  


Xaa Ile Xaa Pro Pro Asp Arg Phe Arg Glu Gly Phe Leu Glu Glu Glu 
                85                  90                  95      


Ala Asn Val Ser Ala Gly Arg Arg Asn Asp Val Trp Asp Ala Ser Asn 
            100                 105                 110         


Gly Arg Ser Met Ala 
        115         


<210> 2187
<211> 51
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<400> 2187
Xaa Gln Xaa Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln 
1               5                   10                  15      


Leu Met Lys Xaa Glu Arg Pro Arg Pro Asn Xaa Phe Val Ile Arg Cys 
            20                  25                  30          


Leu Gln Trp Xaa Xaa Val Ile Glu Arg Xaa Phe His Val Asp Ser Pro 
        35                  40                  45              


Asp Glu Ser 
    50      


<210> 2188
<211> 139
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(138)
<223> Selenocysteine

<400> 2188
Met Ser Asp Val Xaa Ile Val Lys Glu Gly Trp Val Gln Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Asn Trp Arg Pro Arg Tyr Phe Leu Leu Lys Xaa Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Lys Pro Gln Asp Val Asp Leu Pro 
        35                  40                  45              


Tyr Pro Leu Asn Asn Phe Ser Val Ala Lys Cys Gln Leu Met Lys Xaa 
    50                  55                  60                  


Glu Arg Pro Lys Pro Asn Xaa Phe Ile Ile Arg Cys Leu Gln Trp Xaa 
65                  70                  75                  80  


Xaa Val Ile Glu Arg Xaa Phe His Val Asp Xaa Pro Glu Glu Arg Glu 
                85                  90                  95      


Glu Trp Xaa Glu Ala Ile Gln Ala Val Ala Asp Arg Leu Gln Arg Gln 
            100                 105                 110         


Glu Glu Glu Arg Met Asn Cys Ser Pro Xaa Ser Gln Ile Asp Asn Ile 
        115                 120                 125             


Gly Glu Glu Glu Met Asp Ala Ser Xaa Xaa His 
    130                 135                 


<210> 2189
<211> 465
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<400> 2189
Met Ser Asp Val Xaa Ile Val Lys Glu Gly Trp Val Gln Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Asn Trp Arg Pro Arg Tyr Phe Leu Leu Lys Xaa Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Lys Pro Gln Asp Val Asp Leu Pro 
        35                  40                  45              


Tyr Pro Leu Asn Asn Phe Ser Val Ala Lys Cys Gln Leu Met Lys Xaa 
    50                  55                  60                  


Glu Arg Pro Lys Pro Asn Xaa Phe Ile Ile Arg Cys Leu Gln Trp Xaa 
65                  70                  75                  80  


Xaa Val Ile Glu Arg Xaa Phe His Val Asp Xaa Pro Glu Glu Arg Glu 
                85                  90                  95      


Glu Trp Xaa Glu Ala Ile Gln Ala Val Ala Asp Arg Leu Gln Arg Gln 
            100                 105                 110         


Glu Glu Glu Arg Met Asn Cys Ser Pro Xaa Ser Gln Ile Asp Asn Ile 
        115                 120                 125             


Gly Glu Glu Glu Met Asp Ala Ser Xaa Xaa His His Lys Arg Lys Xaa 
    130                 135                 140                 


Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys Gly Xaa Phe Gly 
145                 150                 155                 160 


Lys Val Ile Leu Val Arg Glu Lys Ala Ser Gly Lys Tyr Tyr Ala Met 
                165                 170                 175     


Lys Ile Leu Lys Lys Glu Val Ile Ile Ala Lys Asp Glu Val Ala His 
            180                 185                 190         


Xaa Leu Xaa Glu Ser Arg Val Leu Lys Asn Xaa Arg His Pro Phe Leu 
        195                 200                 205             


Xaa Ser Leu Lys Tyr Ser Phe Gln Xaa Lys Asp Arg Leu Cys Phe Val 
    210                 215                 220                 


Met Glu Tyr Val Asn Gly Gly Glu Leu Phe Phe His Leu Ser Arg Glu 
225                 230                 235                 240 


Arg Val Phe Ser Glu Asp Arg Xaa Arg Phe Tyr Gly Ala Glu Ile Val 
                245                 250                 255     


Ser Ala Leu Asp Tyr Leu His Ser Gly Lys Ile Val Tyr Arg Asp Leu 
            260                 265                 270         


Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile Lys Ile Xaa 
        275                 280                 285             


Asp Phe Gly Leu Cys Lys Glu Gly Ile Xaa Asp Ala Ala Xaa Met Lys 
    290                 295                 300                 


Xaa Phe Cys Gly Xaa Pro Glu Tyr Leu Ala Pro Glu Val Leu Glu Asp 
305                 310                 315                 320 


Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly Val Val Met 
                325                 330                 335     


Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln Asp His Glu 
            340                 345                 350         


Lys Leu Phe Glu Leu Ile Leu Met Glu Asp Ile Lys Phe Pro Arg Xaa 
        355                 360                 365             


Leu Ser Ser Asp Ala Lys Ser Leu Leu Ser Gly Leu Leu Ile Lys Asp 
    370                 375                 380                 


Pro Asn Lys Arg Leu Gly Gly Gly Pro Asp Asp Ala Lys Glu Ile Met 
385                 390                 395                 400 


Arg His Ser Phe Phe Ser Gly Val Asn Trp Gln Asp Val Tyr Asp Lys 
                405                 410                 415     


Lys Leu Val Pro Pro Phe Lys Pro Gln Val Xaa Ser Glu Xaa Asp Xaa 
            420                 425                 430         


Arg Tyr Phe Asp Glu Glu Phe Xaa Ala Gln Xaa Ile Xaa Ile Xaa Pro 
        435                 440                 445             


Pro Glu Lys Cys Gln Gln Ser Asp Cys Gly Met Leu Gly Asn Trp Lys 
    450                 455                 460                 


Lys 
465 


<210> 2190
<211> 479
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<400> 2190
Met Ser Asp Val Xaa Ile Val Lys Glu Gly Trp Val Gln Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Asn Trp Arg Pro Arg Tyr Phe Leu Leu Lys Xaa Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Lys Pro Gln Asp Val Asp Leu Pro 
        35                  40                  45              


Tyr Pro Leu Asn Asn Phe Ser Val Ala Lys Cys Gln Leu Met Lys Xaa 
    50                  55                  60                  


Glu Arg Pro Lys Pro Asn Xaa Phe Ile Ile Arg Cys Leu Gln Trp Xaa 
65                  70                  75                  80  


Xaa Val Ile Glu Arg Xaa Phe His Val Asp Xaa Pro Glu Glu Arg Glu 
                85                  90                  95      


Glu Trp Xaa Glu Ala Ile Gln Ala Val Ala Asp Arg Leu Gln Arg Gln 
            100                 105                 110         


Glu Glu Glu Arg Met Asn Cys Ser Pro Xaa Ser Gln Ile Asp Asn Ile 
        115                 120                 125             


Gly Glu Glu Glu Met Asp Ala Ser Xaa Xaa His His Lys Arg Lys Xaa 
    130                 135                 140                 


Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys Gly Xaa Phe Gly 
145                 150                 155                 160 


Lys Val Ile Leu Val Arg Glu Lys Ala Ser Gly Lys Tyr Tyr Ala Met 
                165                 170                 175     


Lys Ile Leu Lys Lys Glu Val Ile Ile Ala Lys Asp Glu Val Ala His 
            180                 185                 190         


Xaa Leu Xaa Glu Ser Arg Val Leu Lys Asn Xaa Arg His Pro Phe Leu 
        195                 200                 205             


Xaa Ser Leu Lys Tyr Ser Phe Gln Xaa Lys Asp Arg Leu Cys Phe Val 
    210                 215                 220                 


Met Glu Tyr Val Asn Gly Gly Glu Leu Phe Phe His Leu Ser Arg Glu 
225                 230                 235                 240 


Arg Val Phe Ser Glu Asp Arg Xaa Arg Phe Tyr Gly Ala Glu Ile Val 
                245                 250                 255     


Ser Ala Leu Asp Tyr Leu His Ser Gly Lys Ile Val Tyr Arg Asp Leu 
            260                 265                 270         


Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile Lys Ile Xaa 
        275                 280                 285             


Asp Phe Gly Leu Cys Lys Glu Gly Ile Xaa Asp Ala Ala Xaa Met Lys 
    290                 295                 300                 


Xaa Phe Cys Gly Xaa Pro Glu Tyr Leu Ala Pro Glu Val Leu Glu Asp 
305                 310                 315                 320 


Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly Val Val Met 
                325                 330                 335     


Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln Asp His Glu 
            340                 345                 350         


Lys Leu Phe Glu Leu Ile Leu Met Glu Asp Ile Lys Phe Pro Arg Xaa 
        355                 360                 365             


Leu Ser Ser Asp Ala Lys Ser Leu Leu Ser Gly Leu Leu Ile Lys Asp 
    370                 375                 380                 


Pro Asn Lys Arg Leu Gly Gly Gly Pro Asp Asp Ala Lys Glu Ile Met 
385                 390                 395                 400 


Arg His Ser Phe Phe Ser Gly Val Asn Trp Gln Asp Val Tyr Asp Lys 
                405                 410                 415     


Lys Leu Val Pro Pro Phe Lys Pro Gln Val Xaa Ser Glu Xaa Asp Xaa 
            420                 425                 430         


Arg Tyr Phe Asp Glu Glu Phe Xaa Ala Gln Xaa Ile Xaa Ile Xaa Pro 
        435                 440                 445             


Pro Glu Lys Tyr Asp Glu Asp Gly Met Asp Cys Met Asp Asn Glu Arg 
    450                 455                 460                 


Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Arg Glu 
465                 470                 475                 


<210> 2191
<211> 570
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<400> 2191
Met Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu 
1               5                   10                  15      


Ile Ser Ala Xaa Val Phe Arg Pro Gly Leu Gly Trp Tyr Xaa Val Asn 
            20                  25                  30          


Ser Ala Tyr Gly Asp Xaa Ile Ile Ile Pro Cys Arg Leu Asp Val Pro 
        35                  40                  45              


Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser 
    50                  55                  60                  


Pro Val Phe Ile Ala Phe Arg Ser Ser Xaa Lys Lys Ser Val Gln Tyr 
65                  70                  75                  80  


Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr 
                85                  90                  95      


Xaa Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val 
            100                 105                 110         


Cys Met Leu Val Xaa Glu Asp Asn Val Phe Glu Ala Pro Xaa Ile Val 
        115                 120                 125             


Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu 
    130                 135                 140                 


Phe Leu Glu Xaa Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu 
145                 150                 155                 160 


Asp Ser Tyr Pro Asp Gly Asn Ile Xaa Trp Tyr Arg Asn Gly Lys Val 
                165                 170                 175     


Leu His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met 
            180                 185                 190         


Asp Pro Val Xaa Gln Leu Tyr Xaa Met Xaa Ser Xaa Leu Glu Tyr Lys 
        195                 200                 205             


Xaa Xaa Lys Ala Asp Ile Gln Met Pro Phe Xaa Cys Ser Val Xaa Tyr 
    210                 215                 220                 


Tyr Gly Pro Ser Gly Gln Lys Xaa Ile His Ser Glu Gln Ala Val Phe 
225                 230                 235                 240 


Asp Ile Tyr Tyr Pro Xaa Glu Gln Val Xaa Ile Gln Val Leu Pro Pro 
                245                 250                 255     


Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Xaa Leu Lys Cys Leu Gly 
            260                 265                 270         


Asn Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln 
        275                 280                 285             


Pro Glu Gly Ile Arg Ser Ser Asn Xaa Tyr Xaa Leu Xaa Asp Val Arg 
    290                 295                 300                 


Arg Asn Ala Xaa Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser 
305                 310                 315                 320 


Met Ile Ala Ser Xaa Ala Ile Xaa Val His Tyr Leu Asp Leu Ser Leu 
                325                 330                 335     


Asn Pro Ser Gly Glu Val Xaa Arg Gln Ile Gly Asp Ala Leu Pro Val 
            340                 345                 350         


Ser Cys Xaa Ile Ser Ala Ser Arg Asn Ala Xaa Val Val Trp Met Lys 
        355                 360                 365             


Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr 
    370                 375                 380                 


Gln Asp Ala Gly Asn Tyr Val Cys Glu Xaa Ala Leu Gln Glu Val Glu 
385                 390                 395                 400 


Gly Leu Lys Lys Arg Glu Ser Leu Xaa Leu Ile Val Glu Gly Lys Pro 
                405                 410                 415     


Gln Ile Lys Met Xaa Lys Lys Xaa Asp Pro Ser Gly Leu Ser Lys Xaa 
            420                 425                 430         


Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Xaa 
        435                 440                 445             


Ile Xaa Gly Ser Gly Ser Val Ile Asn Gln Xaa Glu Glu Ser Pro Tyr 
    450                 455                 460                 


Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn 
465                 470                 475                 480 


Val Xaa Leu Xaa Cys Xaa Ala Glu Asn Gln Leu Glu Arg Xaa Val Asn 
                485                 490                 495     


Ser Leu Asn Val Ser Ala Asn Glu Asn Arg Glu Lys Val Asn Asp Gln 
            500                 505                 510         


Ala Lys Leu Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu 
        515                 520                 525             


Val Ala Gly Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Xaa Ala 
    530                 535                 540                 


Ser Lys His Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys 
545                 550                 555                 560 


Leu Glu Glu Asn Asn His Lys Xaa Glu Ala 
                565                 570 


<210> 2192
<211> 583
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<400> 2192
Met Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu 
1               5                   10                  15      


Ile Ser Ala Xaa Val Phe Arg Pro Gly Leu Gly Trp Tyr Xaa Val Asn 
            20                  25                  30          


Ser Ala Tyr Gly Asp Xaa Ile Ile Ile Pro Cys Arg Leu Asp Val Pro 
        35                  40                  45              


Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser 
    50                  55                  60                  


Pro Val Phe Ile Ala Phe Arg Ser Ser Xaa Lys Lys Ser Val Gln Tyr 
65                  70                  75                  80  


Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr 
                85                  90                  95      


Xaa Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val 
            100                 105                 110         


Cys Met Leu Val Xaa Glu Asp Asn Val Phe Glu Ala Pro Xaa Ile Val 
        115                 120                 125             


Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu 
    130                 135                 140                 


Phe Leu Glu Xaa Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu 
145                 150                 155                 160 


Asp Ser Tyr Pro Asp Gly Asn Ile Xaa Trp Tyr Arg Asn Gly Lys Val 
                165                 170                 175     


Leu His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met 
            180                 185                 190         


Asp Pro Val Xaa Gln Leu Tyr Xaa Met Xaa Ser Xaa Leu Glu Tyr Lys 
        195                 200                 205             


Xaa Xaa Lys Ala Asp Ile Gln Met Pro Phe Xaa Cys Ser Val Xaa Tyr 
    210                 215                 220                 


Tyr Gly Pro Ser Gly Gln Lys Xaa Ile His Ser Glu Gln Ala Val Phe 
225                 230                 235                 240 


Asp Ile Tyr Tyr Pro Xaa Glu Gln Val Xaa Ile Gln Val Leu Pro Pro 
                245                 250                 255     


Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Xaa Leu Lys Cys Leu Gly 
            260                 265                 270         


Asn Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln 
        275                 280                 285             


Pro Glu Gly Ile Arg Ser Ser Asn Xaa Tyr Xaa Leu Xaa Asp Val Arg 
    290                 295                 300                 


Arg Asn Ala Xaa Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser 
305                 310                 315                 320 


Met Ile Ala Ser Xaa Ala Ile Xaa Val His Tyr Leu Asp Leu Ser Leu 
                325                 330                 335     


Asn Pro Ser Gly Glu Val Xaa Arg Gln Ile Gly Asp Ala Leu Pro Val 
            340                 345                 350         


Ser Cys Xaa Ile Ser Ala Ser Arg Asn Ala Xaa Val Val Trp Met Lys 
        355                 360                 365             


Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr 
    370                 375                 380                 


Gln Asp Ala Gly Asn Tyr Val Cys Glu Xaa Ala Leu Gln Glu Val Glu 
385                 390                 395                 400 


Gly Leu Lys Lys Arg Glu Ser Leu Xaa Leu Ile Val Glu Gly Lys Pro 
                405                 410                 415     


Gln Ile Lys Met Xaa Lys Lys Xaa Asp Pro Ser Gly Leu Ser Lys Xaa 
            420                 425                 430         


Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Xaa 
        435                 440                 445             


Ile Xaa Gly Ser Gly Ser Val Ile Asn Gln Xaa Glu Glu Ser Pro Tyr 
    450                 455                 460                 


Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn 
465                 470                 475                 480 


Val Xaa Leu Xaa Cys Xaa Ala Glu Asn Gln Leu Glu Arg Xaa Val Asn 
                485                 490                 495     


Ser Leu Asn Val Ser Ala Ile Ser Ile Pro Glu His Asp Glu Ala Asp 
            500                 505                 510         


Glu Ile Ser Asp Glu Asn Arg Glu Lys Val Asn Asp Gln Ala Lys Leu 
        515                 520                 525             


Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu Val Ala Gly 
    530                 535                 540                 


Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Xaa Ala Ser Lys His 
545                 550                 555                 560 


Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys Leu Glu Glu 
                565                 570                 575     


Asn Asn His Lys Xaa Glu Ala 
            580             


<210> 2193
<211> 532
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<400> 2193
Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser Pro Val Phe 
1               5                   10                  15      


Ile Ala Phe Arg Ser Ser Xaa Lys Lys Ser Val Gln Tyr Asp Asp Val 
            20                  25                  30          


Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr Xaa Leu Ser 
        35                  40                  45              


Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val Cys Met Leu 
    50                  55                  60                  


Val Xaa Glu Asp Asn Val Phe Glu Ala Pro Xaa Ile Val Lys Val Phe 
65                  70                  75                  80  


Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu Phe Leu Glu 
                85                  90                  95      


Xaa Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu Asp Ser Tyr 
            100                 105                 110         


Pro Asp Gly Asn Ile Xaa Trp Tyr Arg Asn Gly Lys Val Leu His Pro 
        115                 120                 125             


Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met Asp Pro Val 
    130                 135                 140                 


Xaa Gln Leu Tyr Xaa Met Xaa Ser Xaa Leu Glu Tyr Lys Xaa Xaa Lys 
145                 150                 155                 160 


Ala Asp Ile Gln Met Pro Phe Xaa Cys Ser Val Xaa Tyr Tyr Gly Pro 
                165                 170                 175     


Ser Gly Gln Lys Xaa Ile His Ser Glu Gln Ala Val Phe Asp Ile Tyr 
            180                 185                 190         


Tyr Pro Xaa Glu Gln Val Xaa Ile Gln Val Leu Pro Pro Lys Asn Ala 
        195                 200                 205             


Ile Lys Glu Gly Asp Asn Ile Xaa Leu Lys Cys Leu Gly Asn Gly Asn 
    210                 215                 220                 


Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln Pro Glu Gly 
225                 230                 235                 240 


Ile Arg Ser Ser Asn Xaa Tyr Xaa Leu Xaa Asp Val Arg Arg Asn Ala 
                245                 250                 255     


Xaa Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser Met Ile Ala 
            260                 265                 270         


Ser Xaa Ala Ile Xaa Val His Tyr Leu Asp Leu Ser Leu Asn Pro Ser 
        275                 280                 285             


Gly Glu Val Xaa Arg Gln Ile Gly Asp Ala Leu Pro Val Ser Cys Xaa 
    290                 295                 300                 


Ile Ser Ala Ser Arg Asn Ala Xaa Val Val Trp Met Lys Asp Asn Ile 
305                 310                 315                 320 


Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr Gln Asp Ala 
                325                 330                 335     


Gly Asn Tyr Val Cys Glu Xaa Ala Leu Gln Glu Val Glu Gly Leu Lys 
            340                 345                 350         


Lys Arg Glu Ser Leu Xaa Leu Ile Val Glu Gly Lys Pro Gln Ile Lys 
        355                 360                 365             


Met Xaa Lys Lys Xaa Asp Pro Ser Gly Leu Ser Lys Xaa Ile Ile Cys 
    370                 375                 380                 


His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Xaa Ile Xaa Gly 
385                 390                 395                 400 


Ser Gly Ser Val Ile Asn Gln Xaa Glu Glu Ser Pro Tyr Ile Asn Gly 
                405                 410                 415     


Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn Val Xaa Leu 
            420                 425                 430         


Xaa Cys Xaa Ala Glu Asn Gln Leu Glu Arg Xaa Val Asn Ser Leu Asn 
        435                 440                 445             


Val Ser Ala Ile Ser Ile Pro Glu His Asp Glu Ala Asp Glu Ile Ser 
    450                 455                 460                 


Asp Glu Asn Arg Glu Lys Val Asn Asp Gln Ala Lys Leu Ile Val Gly 
465                 470                 475                 480 


Ile Val Val Gly Leu Leu Leu Ala Ala Leu Val Ala Gly Val Val Tyr 
                485                 490                 495     


Trp Leu Tyr Met Lys Lys Ser Lys Xaa Ala Ser Lys His Val Asn Lys 
            500                 505                 510         


Asp Leu Gly Asn Met Glu Glu Asn Lys Lys Leu Glu Glu Asn Asn His 
        515                 520                 525             


Lys Xaa Glu Ala 
    530         


<210> 2194
<211> 344
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<400> 2194
Xaa Leu Gly Asp Cys Ile Ser Glu Asp Ser Tyr Pro Asp Gly Asn Ile 
1               5                   10                  15      


Xaa Trp Tyr Arg Asn Gly Lys Val Leu His Pro Leu Glu Gly Ala Val 
            20                  25                  30          


Val Ile Ile Phe Lys Lys Glu Met Asp Pro Val Xaa Gln Leu Tyr Xaa 
        35                  40                  45              


Met Xaa Ser Xaa Leu Glu Tyr Lys Xaa Xaa Lys Ala Asp Ile Gln Met 
    50                  55                  60                  


Pro Phe Xaa Cys Ser Val Xaa Tyr Tyr Gly Pro Ser Gly Gln Lys Xaa 
65                  70                  75                  80  


Ile His Ser Glu Gln Ala Val Phe Asp Ile Tyr Tyr Leu Asp Leu Ser 
                85                  90                  95      


Leu Asn Pro Ser Gly Glu Val Xaa Arg Gln Ile Gly Asp Ala Leu Pro 
            100                 105                 110         


Val Ser Cys Xaa Ile Ser Ala Ser Arg Asn Ala Xaa Val Val Trp Met 
        115                 120                 125             


Lys Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His 
    130                 135                 140                 


Tyr Gln Asp Ala Gly Asn Tyr Val Cys Glu Xaa Ala Leu Gln Glu Val 
145                 150                 155                 160 


Glu Gly Leu Lys Lys Arg Glu Ser Leu Xaa Leu Ile Val Glu Gly Lys 
                165                 170                 175     


Pro Gln Ile Lys Met Xaa Lys Lys Xaa Asp Pro Ser Gly Leu Ser Lys 
            180                 185                 190         


Xaa Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp 
        195                 200                 205             


Xaa Ile Xaa Gly Ser Gly Ser Val Ile Asn Gln Xaa Glu Glu Ser Pro 
    210                 215                 220                 


Tyr Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu 
225                 230                 235                 240 


Asn Val Xaa Leu Xaa Cys Xaa Ala Glu Asn Gln Leu Glu Arg Xaa Val 
                245                 250                 255     


Asn Ser Leu Asn Val Ser Ala Ile Ser Ile Pro Glu His Asp Glu Ala 
            260                 265                 270         


Asp Glu Ile Ser Asp Glu Asn Arg Glu Lys Val Asn Asp Gln Ala Lys 
        275                 280                 285             


Leu Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu Val Ala 
    290                 295                 300                 


Gly Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Xaa Ala Ser Lys 
305                 310                 315                 320 


His Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys Leu Glu 
                325                 330                 335     


Glu Asn Asn His Lys Xaa Glu Ala 
            340                 


<210> 2195
<211> 9
<212> PRT
<213> Homo sapiens

<400> 2195
Met Asp Ala Ser Glu Arg Gly Arg Leu 
1               5                   


<210> 2196
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2196
Met Asp Ala Ser Glu Arg Gly Arg Leu Leu Asp Lys Leu Ala Asp Leu 
1               5                   10                  15      


Val Glu Arg Asp Arg Ala Val Leu Ala 
            20                  25  


<210> 2197
<211> 85
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<400> 2197
Met Asp Ala Ser Glu Arg Gly Arg Leu Leu Asp Lys Leu Ala Asp Leu 
1               5                   10                  15      


Val Glu Arg Asp Arg Ala Val Leu Ala Xaa Met Glu Ser Leu Asn Gly 
            20                  25                  30          


Gly Lys Pro Phe Leu Gln Ala Phe Tyr Val Asp Leu Gln Gly Val Ile 
        35                  40                  45              


Lys Xaa Phe Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Ile His Gly Met 
    50                  55                  60                  


Xaa Ile Pro Val Asp Gly Asp Tyr Phe Xaa Phe Xaa Arg His Glu Pro 
65                  70                  75                  80  


Ile Gly Val Cys Gly 
                85  


<210> 2198
<211> 422
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<400> 2198
Met Asp Ala Ser Glu Arg Gly Arg Leu Leu Asp Lys Leu Ala Asp Leu 
1               5                   10                  15      


Val Glu Arg Asp Arg Ala Val Leu Ala Xaa Met Glu Ser Leu Asn Gly 
            20                  25                  30          


Gly Lys Pro Phe Leu Gln Ala Phe Tyr Val Asp Leu Gln Gly Val Ile 
        35                  40                  45              


Lys Xaa Phe Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Ile His Gly Met 
    50                  55                  60                  


Xaa Ile Pro Val Asp Gly Asp Tyr Phe Xaa Phe Xaa Arg His Glu Pro 
65                  70                  75                  80  


Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met 
                85                  90                  95      


Phe Ala Trp Lys Ile Ala Pro Ala Leu Cys Cys Gly Asn Xaa Val Val 
            100                 105                 110         


Ile Lys Pro Ala Glu Gln Xaa Pro Leu Ser Ala Leu Tyr Met Gly Ala 
        115                 120                 125             


Leu Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Ile Asn Ile Leu Pro 
    130                 135                 140                 


Gly Tyr Gly Pro Xaa Ala Gly Ala Ala Ile Ala Ser His Ile Gly Ile 
145                 150                 155                 160 


Asp Lys Ile Ala Phe Xaa Gly Ser Xaa Glu Val Gly Lys Leu Ile Gln 
                165                 170                 175     


Glu Ala Ala Gly Arg Ser Asn Leu Lys Arg Val Xaa Leu Glu Leu Gly 
            180                 185                 190         


Gly Lys Ser Pro Asn Ile Ile Phe Ala Asp Ala Asp Leu Asp Tyr Ala 
        195                 200                 205             


Val Glu Gln Ala His Gln Gly Val Phe Phe Asn Gln Gly Gln Cys Cys 
    210                 215                 220                 


Xaa Ala Gly Ser Arg Ile Phe Val Glu Glu Ser Ile Tyr Glu Glu Phe 
225                 230                 235                 240 


Val Arg Arg Ser Val Glu Arg Ala Lys Arg Arg Val Val Gly Ser Pro 
                245                 250                 255     


Phe Asp Pro Xaa Xaa Glu Gln Gly Pro Gln Ile Asp Lys Lys Gln Tyr 
            260                 265                 270         


Asn Lys Ile Leu Glu Leu Ile Gln Ser Gly Val Ala Glu Gly Ala Lys 
        275                 280                 285             


Leu Glu Cys Gly Gly Lys Gly Leu Gly Arg Lys Gly Phe Phe Ile Glu 
    290                 295                 300                 


Pro Xaa Val Phe Ser Asn Val Xaa Asp Asp Met Arg Ile Ala Lys Glu 
305                 310                 315                 320 


Glu Ile Phe Gly Pro Val Gln Glu Ile Leu Arg Phe Lys Xaa Met Asp 
                325                 330                 335     


Glu Val Ile Glu Arg Ala Asn Asn Ser Asp Phe Gly Leu Val Ala Ala 
            340                 345                 350         


Val Phe Xaa Asn Asp Ile Asn Lys Ala Leu Xaa Val Ser Ser Ala Met 
        355                 360                 365             


Gln Ala Gly Xaa Val Trp Ile Asn Cys Tyr Asn Ala Leu Asn Ala Gln 
    370                 375                 380                 


Ser Pro Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg Glu Met Gly 
385                 390                 395                 400 


Glu Phe Gly Leu Arg Glu Tyr Ser Glu Val Lys Xaa Val Xaa Val Lys 
                405                 410                 415     


Ile Pro Gln Lys Asn Ser 
            420         


<210> 2199
<211> 489
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<400> 2199
Met Lys Gly Arg Asn Trp Lys Xaa Xaa Lys Ile Phe Ile Asn Asn Glu 
1               5                   10                  15      


Trp Gln Asn Ser Glu Ser Gly Arg Val Phe Pro Val Tyr Asn Pro Ala 
            20                  25                  30          


Xaa Gly Glu Gln Val Cys Glu Val Gln Glu Ala Asp Lys Ala Asp Ile 
        35                  40                  45              


Asp Lys Ala Val Gln Ala Ala Arg Leu Ala Phe Ser Leu Gly Ser Val 
    50                  55                  60                  


Trp Arg Arg Met Asp Ala Ser Glu Arg Gly Arg Leu Leu Asp Lys Leu 
65                  70                  75                  80  


Ala Asp Leu Val Glu Arg Asp Arg Ala Val Leu Ala Xaa Met Glu Ser 
                85                  90                  95      


Leu Asn Gly Gly Lys Pro Phe Leu Gln Ala Phe Tyr Val Asp Leu Gln 
            100                 105                 110         


Gly Val Ile Lys Xaa Phe Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Ile 
        115                 120                 125             


His Gly Met Xaa Ile Pro Val Asp Gly Asp Tyr Phe Xaa Phe Xaa Arg 
    130                 135                 140                 


His Glu Pro Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro 
145                 150                 155                 160 


Leu Leu Met Phe Ala Trp Lys Ile Ala Pro Ala Leu Cys Cys Gly Asn 
                165                 170                 175     


Xaa Val Val Ile Lys Pro Ala Glu Gln Xaa Pro Leu Ser Ala Leu Tyr 
            180                 185                 190         


Met Gly Ala Leu Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Ile Asn 
        195                 200                 205             


Ile Leu Pro Gly Tyr Gly Pro Xaa Ala Gly Ala Ala Ile Ala Ser His 
    210                 215                 220                 


Ile Gly Ile Asp Lys Ile Ala Phe Xaa Gly Ser Xaa Glu Val Gly Lys 
225                 230                 235                 240 


Leu Ile Gln Glu Ala Ala Gly Arg Ser Asn Leu Lys Arg Val Xaa Leu 
                245                 250                 255     


Glu Leu Gly Gly Lys Ser Pro Asn Ile Ile Phe Ala Asp Ala Asp Leu 
            260                 265                 270         


Asp Tyr Ala Val Glu Gln Ala His Gln Gly Val Phe Phe Asn Gln Gly 
        275                 280                 285             


Gln Cys Cys Xaa Ala Gly Ser Arg Ile Phe Val Glu Glu Ser Ile Tyr 
    290                 295                 300                 


Glu Glu Phe Val Arg Arg Ser Val Glu Arg Ala Lys Arg Arg Val Val 
305                 310                 315                 320 


Gly Ser Pro Phe Asp Pro Xaa Xaa Glu Gln Gly Pro Gln Ile Asp Lys 
                325                 330                 335     


Lys Gln Tyr Asn Lys Ile Leu Glu Leu Ile Gln Ser Gly Val Ala Glu 
            340                 345                 350         


Gly Ala Lys Leu Glu Cys Gly Gly Lys Gly Leu Gly Arg Lys Gly Phe 
        355                 360                 365             


Phe Ile Glu Pro Xaa Val Phe Ser Asn Val Xaa Asp Asp Met Arg Ile 
    370                 375                 380                 


Ala Lys Glu Glu Ile Phe Gly Pro Val Gln Glu Ile Leu Arg Phe Lys 
385                 390                 395                 400 


Xaa Met Asp Glu Val Ile Glu Arg Ala Asn Asn Ser Asp Phe Gly Leu 
                405                 410                 415     


Val Ala Ala Val Phe Xaa Asn Asp Ile Asn Lys Ala Leu Xaa Val Ser 
            420                 425                 430         


Ser Ala Met Gln Ala Gly Xaa Val Trp Ile Asn Cys Tyr Asn Ala Leu 
        435                 440                 445             


Asn Ala Gln Ser Pro Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg 
    450                 455                 460                 


Glu Met Gly Glu Phe Gly Leu Arg Glu Tyr Ser Glu Val Lys Xaa Val 
465                 470                 475                 480 


Xaa Val Lys Ile Pro Gln Lys Asn Ser 
                485                 


<210> 2200
<211> 497
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<400> 2200
Met Lys Asn Gln Cys Glu Xaa Val Trp Leu Lys Ser Pro Ile Lys Leu 
1               5                   10                  15      


Lys Leu Ile Phe Ile Asn Asn Glu Trp Gln Asn Ser Glu Ser Gly Arg 
            20                  25                  30          


Val Phe Pro Val Tyr Asn Pro Ala Xaa Gly Glu Gln Val Cys Glu Val 
        35                  40                  45              


Gln Glu Ala Asp Lys Ala Asp Ile Asp Lys Ala Val Gln Ala Ala Arg 
    50                  55                  60                  


Leu Ala Phe Ser Leu Gly Ser Val Trp Arg Arg Met Asp Ala Ser Glu 
65                  70                  75                  80  


Arg Gly Arg Leu Leu Asp Lys Leu Ala Asp Leu Val Glu Arg Asp Arg 
                85                  90                  95      


Ala Val Leu Ala Xaa Met Glu Ser Leu Asn Gly Gly Lys Pro Phe Leu 
            100                 105                 110         


Gln Ala Phe Tyr Val Asp Leu Gln Gly Val Ile Lys Xaa Phe Arg Tyr 
        115                 120                 125             


Tyr Ala Gly Trp Ala Asp Lys Ile His Gly Met Xaa Ile Pro Val Asp 
    130                 135                 140                 


Gly Asp Tyr Phe Xaa Phe Xaa Arg His Glu Pro Ile Gly Val Cys Gly 
145                 150                 155                 160 


Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met Phe Ala Trp Lys Ile 
                165                 170                 175     


Ala Pro Ala Leu Cys Cys Gly Asn Xaa Val Val Ile Lys Pro Ala Glu 
            180                 185                 190         


Gln Xaa Pro Leu Ser Ala Leu Tyr Met Gly Ala Leu Ile Lys Glu Ala 
        195                 200                 205             


Gly Phe Pro Pro Gly Val Ile Asn Ile Leu Pro Gly Tyr Gly Pro Xaa 
    210                 215                 220                 


Ala Gly Ala Ala Ile Ala Ser His Ile Gly Ile Asp Lys Ile Ala Phe 
225                 230                 235                 240 


Xaa Gly Ser Xaa Glu Val Gly Lys Leu Ile Gln Glu Ala Ala Gly Arg 
                245                 250                 255     


Ser Asn Leu Lys Arg Val Xaa Leu Glu Leu Gly Gly Lys Ser Pro Asn 
            260                 265                 270         


Ile Ile Phe Ala Asp Ala Asp Leu Asp Tyr Ala Val Glu Gln Ala His 
        275                 280                 285             


Gln Gly Val Phe Phe Asn Gln Gly Gln Cys Cys Xaa Ala Gly Ser Arg 
    290                 295                 300                 


Ile Phe Val Glu Glu Ser Ile Tyr Glu Glu Phe Val Arg Arg Ser Val 
305                 310                 315                 320 


Glu Arg Ala Lys Arg Arg Val Val Gly Ser Pro Phe Asp Pro Xaa Xaa 
                325                 330                 335     


Glu Gln Gly Pro Gln Ile Asp Lys Lys Gln Tyr Asn Lys Ile Leu Glu 
            340                 345                 350         


Leu Ile Gln Ser Gly Val Ala Glu Gly Ala Lys Leu Glu Cys Gly Gly 
        355                 360                 365             


Lys Gly Leu Gly Arg Lys Gly Phe Phe Ile Glu Pro Xaa Val Phe Ser 
    370                 375                 380                 


Asn Val Xaa Asp Asp Met Arg Ile Ala Lys Glu Glu Ile Phe Gly Pro 
385                 390                 395                 400 


Val Gln Glu Ile Leu Arg Phe Lys Xaa Met Asp Glu Val Ile Glu Arg 
                405                 410                 415     


Ala Asn Asn Ser Asp Phe Gly Leu Val Ala Ala Val Phe Xaa Asn Asp 
            420                 425                 430         


Ile Asn Lys Ala Leu Xaa Val Ser Ser Ala Met Gln Ala Gly Xaa Val 
        435                 440                 445             


Trp Ile Asn Cys Tyr Asn Ala Leu Asn Ala Gln Ser Pro Phe Gly Gly 
    450                 455                 460                 


Phe Lys Met Ser Gly Asn Gly Arg Glu Met Gly Glu Phe Gly Leu Arg 
465                 470                 475                 480 


Glu Tyr Ser Glu Val Lys Xaa Val Xaa Val Lys Ile Pro Gln Lys Asn 
                485                 490                 495     


Ser 
    


<210> 2201
<211> 518
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<400> 2201
Met Xaa Ser Ser Lys Ile Glu Met Pro Gly Glu Val Lys Ala Asp Pro 
1               5                   10                  15      


Ala Ala Leu Met Ala Ser Leu His Leu Leu Pro Ser Pro Xaa Pro Asn 
            20                  25                  30          


Leu Glu Ile Lys Tyr Xaa Lys Ile Phe Ile Asn Asn Glu Trp Gln Asn 
        35                  40                  45              


Ser Glu Ser Gly Arg Val Phe Pro Val Tyr Asn Pro Ala Xaa Gly Glu 
    50                  55                  60                  


Gln Val Cys Glu Val Gln Glu Ala Asp Lys Ala Asp Ile Asp Lys Ala 
65                  70                  75                  80  


Val Gln Ala Ala Arg Leu Ala Phe Ser Leu Gly Ser Val Trp Arg Arg 
                85                  90                  95      


Met Asp Ala Ser Glu Arg Gly Arg Leu Leu Asp Lys Leu Ala Asp Leu 
            100                 105                 110         


Val Glu Arg Asp Arg Ala Val Leu Ala Xaa Met Glu Ser Leu Asn Gly 
        115                 120                 125             


Gly Lys Pro Phe Leu Gln Ala Phe Tyr Val Asp Leu Gln Gly Val Ile 
    130                 135                 140                 


Lys Xaa Phe Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Ile His Gly Met 
145                 150                 155                 160 


Xaa Ile Pro Val Asp Gly Asp Tyr Phe Xaa Phe Xaa Arg His Glu Pro 
                165                 170                 175     


Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met 
            180                 185                 190         


Phe Ala Trp Lys Ile Ala Pro Ala Leu Cys Cys Gly Asn Xaa Val Val 
        195                 200                 205             


Ile Lys Pro Ala Glu Gln Xaa Pro Leu Ser Ala Leu Tyr Met Gly Ala 
    210                 215                 220                 


Leu Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Ile Asn Ile Leu Pro 
225                 230                 235                 240 


Gly Tyr Gly Pro Xaa Ala Gly Ala Ala Ile Ala Ser His Ile Gly Ile 
                245                 250                 255     


Asp Lys Ile Ala Phe Xaa Gly Ser Xaa Glu Val Gly Lys Leu Ile Gln 
            260                 265                 270         


Glu Ala Ala Gly Arg Ser Asn Leu Lys Arg Val Xaa Leu Glu Leu Gly 
        275                 280                 285             


Gly Lys Ser Pro Asn Ile Ile Phe Ala Asp Ala Asp Leu Asp Tyr Ala 
    290                 295                 300                 


Val Glu Gln Ala His Gln Gly Val Phe Phe Asn Gln Gly Gln Cys Cys 
305                 310                 315                 320 


Xaa Ala Gly Ser Arg Ile Phe Val Glu Glu Ser Ile Tyr Glu Glu Phe 
                325                 330                 335     


Val Arg Arg Ser Val Glu Arg Ala Lys Arg Arg Val Val Gly Ser Pro 
            340                 345                 350         


Phe Asp Pro Xaa Xaa Glu Gln Gly Pro Gln Ile Asp Lys Lys Gln Tyr 
        355                 360                 365             


Asn Lys Ile Leu Glu Leu Ile Gln Ser Gly Val Ala Glu Gly Ala Lys 
    370                 375                 380                 


Leu Glu Cys Gly Gly Lys Gly Leu Gly Arg Lys Gly Phe Phe Ile Glu 
385                 390                 395                 400 


Pro Xaa Val Phe Ser Asn Val Xaa Asp Asp Met Arg Ile Ala Lys Glu 
                405                 410                 415     


Glu Ile Phe Gly Pro Val Gln Glu Ile Leu Arg Phe Lys Xaa Met Asp 
            420                 425                 430         


Glu Val Ile Glu Arg Ala Asn Asn Ser Asp Phe Gly Leu Val Ala Ala 
        435                 440                 445             


Val Phe Xaa Asn Asp Ile Asn Lys Ala Leu Xaa Val Ser Ser Ala Met 
    450                 455                 460                 


Gln Ala Gly Xaa Val Trp Ile Asn Cys Tyr Asn Ala Leu Asn Ala Gln 
465                 470                 475                 480 


Ser Pro Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg Glu Met Gly 
                485                 490                 495     


Glu Phe Gly Leu Arg Glu Tyr Ser Glu Val Lys Xaa Val Xaa Val Lys 
            500                 505                 510         


Ile Pro Gln Lys Asn Ser 
        515             


<210> 2202
<211> 480
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<400> 2202
Met Xaa Ser Ser Lys Ile Glu Met Pro Gly Glu Val Lys Ala Asp Pro 
1               5                   10                  15      


Ala Ala Leu Met Ala Ser Leu His Leu Leu Pro Ser Pro Xaa Pro Asn 
            20                  25                  30          


Leu Glu Ile Lys Tyr Xaa Lys Ile Phe Ile Asn Asn Glu Trp Gln Asn 
        35                  40                  45              


Ser Glu Ser Gly Arg Val Phe Pro Val Tyr Asn Pro Ala Xaa Gly Glu 
    50                  55                  60                  


Gln Val Cys Glu Val Gln Glu Ala Asp Lys Ala Asp Ile Asp Lys Ala 
65                  70                  75                  80  


Val Gln Ala Ala Arg Leu Ala Phe Ser Leu Gly Ser Val Trp Arg Arg 
                85                  90                  95      


Met Asp Ala Ser Glu Arg Gly Arg Leu Leu Asp Lys Leu Ala Asp Leu 
            100                 105                 110         


Val Glu Arg Asp Arg Ala Val Leu Ala Xaa Met Glu Ser Leu Asn Gly 
        115                 120                 125             


Gly Lys Pro Phe Leu Gln Ala Phe Tyr Val Asp Leu Gln Gly Val Ile 
    130                 135                 140                 


Lys Xaa Phe Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Ile His Gly Met 
145                 150                 155                 160 


Xaa Ile Pro Val Asp Gly Asp Tyr Phe Xaa Phe Xaa Arg His Glu Pro 
                165                 170                 175     


Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met 
            180                 185                 190         


Phe Ala Trp Lys Ile Ala Pro Ala Leu Cys Cys Gly Asn Xaa Val Val 
        195                 200                 205             


Ile Lys Pro Ala Glu Gln Xaa Pro Leu Ser Ala Leu Tyr Met Gly Ala 
    210                 215                 220                 


Leu Ile Lys Glu Val Gly Lys Leu Ile Gln Glu Ala Ala Gly Arg Ser 
225                 230                 235                 240 


Asn Leu Lys Arg Val Xaa Leu Glu Leu Gly Gly Lys Ser Pro Asn Ile 
                245                 250                 255     


Ile Phe Ala Asp Ala Asp Leu Asp Tyr Ala Val Glu Gln Ala His Gln 
            260                 265                 270         


Gly Val Phe Phe Asn Gln Gly Gln Cys Cys Xaa Ala Gly Ser Arg Ile 
        275                 280                 285             


Phe Val Glu Glu Ser Ile Tyr Glu Glu Phe Val Arg Arg Ser Val Glu 
    290                 295                 300                 


Arg Ala Lys Arg Arg Val Val Gly Ser Pro Phe Asp Pro Xaa Xaa Glu 
305                 310                 315                 320 


Gln Gly Pro Gln Ile Asp Lys Lys Gln Tyr Asn Lys Ile Leu Glu Leu 
                325                 330                 335     


Ile Gln Ser Gly Val Ala Glu Gly Ala Lys Leu Glu Cys Gly Gly Lys 
            340                 345                 350         


Gly Leu Gly Arg Lys Gly Phe Phe Ile Glu Pro Xaa Val Phe Ser Asn 
        355                 360                 365             


Val Xaa Asp Asp Met Arg Ile Ala Lys Glu Glu Ile Phe Gly Pro Val 
    370                 375                 380                 


Gln Glu Ile Leu Arg Phe Lys Xaa Met Asp Glu Val Ile Glu Arg Ala 
385                 390                 395                 400 


Asn Asn Ser Asp Phe Gly Leu Val Ala Ala Val Phe Xaa Asn Asp Ile 
                405                 410                 415     


Asn Lys Ala Leu Xaa Val Ser Ser Ala Met Gln Ala Gly Xaa Val Trp 
            420                 425                 430         


Ile Asn Cys Tyr Asn Ala Leu Asn Ala Gln Ser Pro Phe Gly Gly Phe 
        435                 440                 445             


Lys Met Ser Gly Asn Gly Arg Glu Met Gly Glu Phe Gly Leu Arg Glu 
    450                 455                 460                 


Tyr Ser Glu Val Lys Xaa Val Xaa Val Lys Ile Pro Gln Lys Asn Ser 
465                 470                 475                 480 


<210> 2203
<211> 40
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<400> 2203
Met Xaa Ser Ser Lys Ile Glu Met Pro Gly Glu Val Lys Ala Asp Pro 
1               5                   10                  15      


Ala Ala Leu Met Ala Ser Leu His Leu Leu Pro Ser Pro Xaa Pro Asn 
            20                  25                  30          


Leu Glu Ile Lys Tyr Xaa Lys Val 
        35                  40  


<210> 2204
<211> 24
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<400> 2204
Xaa Gly Glu Phe Gly Leu Arg Glu Tyr Ser Glu Val Lys Xaa Val Xaa 
1               5                   10                  15      


Val Lys Ile Pro Gln Lys Asn Ser 
            20                  


<210> 2205
<211> 1620
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1117)..(1117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1211)..(1211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1343)..(1343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1363)..(1363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1387)..(1387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1395)..(1395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1500)..(1500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1512)..(1512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1516)..(1516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1540)..(1540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1563)..(1563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1597)..(1597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<400> 2205
Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Xaa 
1               5                   10                  15      


Ala Ala Val Gly Ser Gly Met Gly Xaa Gly Gln Arg Ala Gly Ser Pro 
            20                  25                  30          


Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg 
        35                  40                  45              


Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala 
                85                  90                  95      


Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Xaa Ala 
            100                 105                 110         


Gly Ser Pro Ala Pro Ala Glu Ala Arg Xaa Leu Ser Arg Val Leu Lys 
        115                 120                 125             


Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu 
    130                 135                 140                 


Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu 
145                 150                 155                 160 


Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp 
                165                 170                 175     


Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu 
            180                 185                 190         


Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile 
        195                 200                 205             


Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Xaa Gly His 
    210                 215                 220                 


Ser Ser Leu Glu Ser Pro Xaa Asn Met Pro Ser Pro Ser Pro Asp Tyr 
225                 230                 235                 240 


Phe Xaa Trp Asn Leu Xaa Trp Ile Met Lys Asp Ser Phe Pro Phe Leu 
                245                 250                 255     


Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys 
            260                 265                 270         


Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp 
        275                 280                 285             


Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu 
    290                 295                 300                 


Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe 
305                 310                 315                 320 


Leu Leu Leu Asn Xaa Ser Ala Asp Ser Lys His Xaa Ile Leu Ser Pro 
                325                 330                 335     


Trp Met Arg Ser Ser Ser Glu His Cys Xaa Leu Ala Val Ser Val His 
            340                 345                 350         


Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His 
        355                 360                 365             


Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Xaa Pro Gly Lys His 
    370                 375                 380                 


Gly Trp Xaa Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe 
385                 390                 395                 400 


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala 
                405                 410                 415     


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Xaa Ser Pro Gly 
            420                 425                 430         


Ser Lys Met Ala Leu Gln Ser Ser Phe Xaa Cys Trp Asn Gly Xaa Val 
        435                 440                 445             


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly 
    450                 455                 460                 


Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys 
465                 470                 475                 480 


Asn Phe Glu Asp Gly Phe Cys Gly Trp Xaa Gln Gly Xaa Leu Ser Pro 
                485                 490                 495     


His Xaa Pro Gln Trp Gln Val Arg Xaa Leu Lys Asp Ala Arg Phe Gln 
            500                 505                 510         


Asp His Gln Asp His Ala Leu Leu Leu Ser Xaa Xaa Asp Val Pro Ala 
        515                 520                 525             


Ser Glu Ser Ala Xaa Val Xaa Ser Ala Xaa Phe Pro Ala Pro Ile Lys 
    530                 535                 540                 


Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu 
545                 550                 555                 560 


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Xaa Gly Lys Glu 
                565                 570                 575     


Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu 
            580                 585                 590         


Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp 
        595                 600                 605             


Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala 
    610                 615                 620                 


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Xaa Ile Ser Gly 
625                 630                 635                 640 


Glu Asp Lys Ile Leu Gln Asn Xaa Ala Pro Lys Ser Arg Asn Leu Phe 
                645                 650                 655     


Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg 
            660                 665                 670         


Gln Xaa Pro Ile Phe Asp Pro Xaa Val His Trp Leu Phe Xaa Xaa Cys 
        675                 680                 685             


Gly Ala Ser Gly Pro His Gly Pro Xaa Gln Ala Gln Cys Asn Asn Ala 
    690                 695                 700                 


Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu 
705                 710                 715                 720 


Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Xaa Asp Xaa Tyr Ser Ile 
                725                 730                 735     


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Xaa Met Met 
            740                 745                 750         


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp 
        755                 760                 765             


Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro 
    770                 775                 780                 


Ser Xaa Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val 
785                 790                 795                 800 


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly 
                805                 810                 815     


Gly Gly Gly Gly Gly Gly Gly Ala Xaa Tyr Val Phe Lys Met Lys Asp 
            820                 825                 830         


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala 
        835                 840                 845             


Tyr Gly Ala Lys Xaa Asp Xaa Phe His Pro Glu Arg Leu Glu Asn Asn 
    850                 855                 860                 


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly 
865                 870                 875                 880 


Gly Gly Trp Asn Asp Asn Xaa Ser Leu Leu Trp Ala Gly Lys Ser Leu 
                885                 890                 895     


Gln Glu Gly Ala Xaa Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys 
            900                 905                 910         


Trp Gly Trp Glu Xaa Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys 
        915                 920                 925             


Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser 
    930                 935                 940                 


Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser 
945                 950                 955                 960 


Pro Leu Gly Ile Leu Tyr Xaa Pro Ala Leu Lys Val Met Glu Gly His 
                965                 970                 975     


Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val 
            980                 985                 990         


Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys Phe Cys 
        995                 1000                 1005             


Asp His  Gly Xaa Val Leu Ala  Glu Asp Gly Val Ser  Cys Ile Val 
    1010                 1015                 1020             


Ser Pro  Xaa Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile Leu Ser 
    1025                 1030                 1035             


Val Val  Xaa Ser Ala Leu Val  Ala Ala Leu Val Leu  Ala Phe Ser 
    1040                 1045                 1050             


Gly Ile  Met Ile Val Tyr Arg  Arg Lys His Gln Glu  Leu Gln Ala 
    1055                 1060                 1065             


Met Gln  Met Glu Leu Gln Ser  Pro Glu Tyr Lys Leu  Ser Lys Leu 
    1070                 1075                 1080             


Arg Xaa  Ser Xaa Ile Met Xaa  Asp Tyr Asn Pro Asn  Tyr Cys Phe 
    1085                 1090                 1095             


Ala Gly  Lys Xaa Ser Ser Ile  Ser Asp Leu Lys Glu  Val Pro Arg 
    1100                 1105                 1110             


Lys Asn  Ile Xaa Leu Ile Arg  Gly Leu Gly His Gly  Ala Phe Gly 
    1115                 1120                 1125             


Glu Val  Tyr Glu Gly Gln Val  Ser Gly Met Pro Asn  Asp Pro Ser 
    1130                 1135                 1140             


Pro Leu  Gln Val Ala Val Lys  Xaa Leu Pro Glu Val  Cys Ser Glu 
    1145                 1150                 1155             


Gln Asp  Glu Leu Asp Phe Leu  Met Glu Ala Leu Ile  Ile Ser Lys 
    1160                 1165                 1170             


Phe Asn  His Gln Asn Ile Val  Arg Cys Ile Gly Val  Ser Leu Gln 
    1175                 1180                 1185             


Ser Leu  Pro Arg Phe Ile Leu  Leu Glu Leu Met Ala  Gly Gly Asp 
    1190                 1195                 1200             


Leu Lys  Ser Phe Leu Arg Glu  Xaa Arg Pro Arg Pro  Ser Gln Pro 
    1205                 1210                 1215             


Ser Ser  Leu Ala Met Leu Asp  Leu Leu His Val Ala  Arg Asp Ile 
    1220                 1225                 1230             


Ala Cys  Gly Cys Gln Tyr Leu  Glu Glu Asn His Phe  Ile His Arg 
    1235                 1240                 1245             


Asp Ile  Ala Ala Arg Asn Cys  Leu Leu Xaa Cys Pro  Gly Pro Gly 
    1250                 1255                 1260             


Arg Val  Ala Lys Ile Gly Asp  Phe Gly Met Ala Arg  Asp Ile Tyr 
    1265                 1270                 1275             


Arg Ala  Ser Tyr Tyr Arg Lys  Gly Gly Cys Ala Met  Leu Pro Val 
    1280                 1285                 1290             


Lys Trp  Met Pro Pro Glu Ala  Phe Met Glu Gly Ile  Phe Xaa Ser 
    1295                 1300                 1305             


Lys Xaa  Asp Xaa Trp Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe 
    1310                 1315                 1320             


Ser Leu  Gly Tyr Met Pro Tyr  Pro Ser Lys Ser Asn  Gln Glu Val 
    1325                 1330                 1335             


Leu Glu  Phe Val Xaa Ser Gly  Gly Arg Met Asp Pro  Pro Lys Asn 
    1340                 1345                 1350             


Cys Pro  Gly Pro Val Tyr Arg  Ile Met Xaa Gln Cys  Trp Gln His 
    1355                 1360                 1365             


Gln Pro  Glu Asp Arg Pro Asn  Phe Ala Ile Ile Leu  Glu Arg Ile 
    1370                 1375                 1380             


Glu Tyr  Cys Xaa Gln Asp Pro  Asp Val Ile Asn Xaa  Ala Leu Pro 
    1385                 1390                 1395             


Ile Glu  Tyr Gly Pro Leu Val  Glu Glu Glu Glu Lys  Val Pro Val 
    1400                 1405                 1410             


Arg Pro  Lys Asp Pro Glu Gly  Val Pro Pro Leu Leu  Val Ser Gln 
    1415                 1420                 1425             


Gln Ala  Lys Arg Glu Glu Glu  Arg Ser Pro Ala Ala  Pro Pro Pro 
    1430                 1435                 1440             


Leu Pro  Xaa Xaa Ser Ser Gly  Lys Ala Ala Lys Lys  Pro Xaa Ala 
    1445                 1450                 1455             


Ala Glu  Ile Ser Val Arg Val  Pro Arg Gly Pro Ala  Val Glu Gly 
    1460                 1465                 1470             


Gly His  Val Asn Met Ala Phe  Ser Gln Ser Asn Pro  Pro Ser Glu 
    1475                 1480                 1485             


Leu His  Lys Val His Gly Ser  Arg Asn Lys Pro Xaa  Ser Leu Trp 
    1490                 1495                 1500             


Asn Pro  Xaa Tyr Gly Ser Trp  Phe Xaa Glu Lys Pro  Xaa Lys Lys 
    1505                 1510                 1515             


Asn Asn  Pro Ile Ala Lys Lys  Glu Pro His Asp Arg  Gly Asn Leu 
    1520                 1525                 1530             


Gly Leu  Glu Gly Ser Cys Xaa  Val Pro Pro Asn Val  Ala Xaa Gly 
    1535                 1540                 1545             


Arg Leu  Pro Gly Ala Ser Leu  Leu Leu Glu Pro Ser  Ser Leu Xaa 
    1550                 1555                 1560             


Ala Asn  Met Lys Glu Val Pro  Leu Phe Arg Leu Arg  His Phe Pro 
    1565                 1570                 1575             


Cys Gly  Asn Val Asn Tyr Gly  Tyr Gln Gln Gln Gly  Leu Pro Leu 
    1580                 1585                 1590             


Glu Ala  Ala Xaa Ala Pro Gly  Ala Gly His Tyr Glu  Asp Xaa Ile 
    1595                 1600                 1605             


Leu Lys  Ser Lys Asn Ser Met  Asn Gln Pro Gly Pro  
    1610                 1615                 1620 


<210> 2206
<211> 1243
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1123)..(1123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<400> 2206
Met Pro Xaa Pro Gly Lys His Gly Trp Xaa Val Leu Gln Gly Arg Ile 
1               5                   10                  15      


Gly Arg Pro Asp Asn Pro Phe Arg Val Ala Leu Glu Tyr Ile Ser Ser 
            20                  25                  30          


Gly Asn Arg Ser Leu Ser Ala Val Asp Phe Phe Ala Leu Lys Asn Cys 
        35                  40                  45              


Ser Glu Gly Xaa Ser Pro Gly Ser Lys Met Ala Leu Gln Ser Ser Phe 
    50                  55                  60                  


Xaa Cys Trp Asn Gly Xaa Val Leu Gln Leu Gly Gln Ala Cys Asp Phe 
65                  70                  75                  80  


His Gln Asp Cys Ala Gln Gly Glu Asp Glu Ser Gln Met Cys Arg Lys 
                85                  90                  95      


Leu Pro Val Gly Phe Tyr Cys Asn Phe Glu Asp Gly Phe Cys Gly Trp 
            100                 105                 110         


Xaa Gln Gly Xaa Leu Ser Pro His Xaa Pro Gln Trp Gln Val Arg Xaa 
        115                 120                 125             


Leu Lys Asp Ala Arg Phe Gln Asp His Gln Asp His Ala Leu Leu Leu 
    130                 135                 140                 


Ser Xaa Xaa Asp Val Pro Ala Ser Glu Ser Ala Xaa Val Xaa Ser Ala 
145                 150                 155                 160 


Xaa Phe Pro Ala Pro Ile Lys Ser Ser Pro Cys Glu Leu Arg Met Ser 
                165                 170                 175     


Trp Leu Ile Arg Gly Val Leu Arg Gly Asn Val Ser Leu Val Leu Val 
            180                 185                 190         


Glu Asn Lys Xaa Gly Lys Glu Gln Gly Arg Met Val Trp His Val Ala 
        195                 200                 205             


Ala Tyr Glu Gly Leu Ser Leu Trp Gln Trp Met Val Leu Pro Leu Leu 
    210                 215                 220                 


Asp Val Ser Asp Arg Phe Trp Leu Gln Met Val Ala Trp Trp Gly Gln 
225                 230                 235                 240 


Gly Ser Arg Ala Ile Val Ala Phe Asp Asn Ile Ser Ile Ser Leu Asp 
                245                 250                 255     


Cys Tyr Leu Xaa Ile Ser Gly Glu Asp Lys Ile Leu Gln Asn Xaa Ala 
            260                 265                 270         


Pro Lys Ser Arg Asn Leu Phe Glu Arg Asn Pro Asn Lys Glu Leu Lys 
        275                 280                 285             


Pro Gly Glu Asn Ser Pro Arg Gln Xaa Pro Ile Phe Asp Pro Xaa Val 
    290                 295                 300                 


His Trp Leu Phe Xaa Xaa Cys Gly Ala Ser Gly Pro His Gly Pro Xaa 
305                 310                 315                 320 


Gln Ala Gln Cys Asn Asn Ala Tyr Gln Asn Ser Asn Leu Ser Val Glu 
                325                 330                 335     


Val Gly Ser Glu Gly Pro Leu Lys Gly Ile Gln Ile Trp Lys Val Pro 
            340                 345                 350         


Ala Xaa Asp Xaa Tyr Ser Ile Ser Gly Tyr Gly Ala Ala Gly Gly Lys 
        355                 360                 365             


Gly Gly Lys Asn Xaa Met Met Arg Ser His Gly Val Ser Val Leu Gly 
    370                 375                 380                 


Ile Phe Asn Leu Glu Lys Asp Asp Met Leu Tyr Ile Leu Val Gly Gln 
385                 390                 395                 400 


Gln Gly Glu Asp Ala Cys Pro Ser Xaa Asn Gln Leu Ile Gln Lys Val 
                405                 410                 415     


Cys Ile Gly Glu Asn Asn Val Ile Glu Glu Glu Ile Arg Val Asn Arg 
            420                 425                 430         


Ser Val His Glu Trp Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala Xaa 
        435                 440                 445             


Tyr Val Phe Lys Met Lys Asp Gly Val Pro Val Pro Leu Ile Ile Ala 
    450                 455                 460                 


Ala Gly Gly Gly Gly Arg Ala Tyr Gly Ala Lys Xaa Asp Xaa Phe His 
465                 470                 475                 480 


Pro Glu Arg Leu Glu Asn Asn Ser Ser Val Leu Gly Leu Asn Gly Asn 
                485                 490                 495     


Ser Gly Ala Ala Gly Gly Gly Gly Gly Trp Asn Asp Asn Xaa Ser Leu 
            500                 505                 510         


Leu Trp Ala Gly Lys Ser Leu Gln Glu Gly Ala Xaa Gly Gly His Ser 
        515                 520                 525             


Cys Pro Gln Ala Met Lys Lys Trp Gly Trp Glu Xaa Arg Gly Gly Phe 
    530                 535                 540                 


Gly Gly Gly Gly Gly Gly Cys Ser Ser Gly Gly Gly Gly Gly Gly Tyr 
545                 550                 555                 560 


Ile Gly Gly Asn Ala Ala Ser Asn Asn Asp Pro Glu Met Asp Gly Glu 
                565                 570                 575     


Asp Gly Val Ser Phe Ile Ser Pro Leu Gly Ile Leu Tyr Xaa Pro Ala 
            580                 585                 590         


Leu Lys Val Met Glu Gly His Gly Glu Val Asn Ile Lys His Tyr Leu 
        595                 600                 605             


Asn Cys Ser His Cys Glu Val Asp Glu Cys His Met Asp Pro Glu Ser 
    610                 615                 620                 


His Lys Val Ile Cys Phe Cys Asp His Gly Xaa Val Leu Ala Glu Asp 
625                 630                 635                 640 


Gly Val Ser Cys Ile Val Ser Pro Xaa Pro Glu Pro His Leu Pro Leu 
                645                 650                 655     


Ser Leu Ile Leu Ser Val Val Xaa Ser Ala Leu Val Ala Ala Leu Val 
            660                 665                 670         


Leu Ala Phe Ser Gly Ile Met Ile Val Tyr Arg Arg Lys His Gln Glu 
        675                 680                 685             


Leu Gln Ala Met Gln Met Glu Leu Gln Ser Pro Glu Tyr Lys Leu Ser 
    690                 695                 700                 


Lys Leu Arg Xaa Ser Xaa Ile Met Xaa Asp Tyr Asn Pro Asn Tyr Cys 
705                 710                 715                 720 


Phe Ala Gly Lys Xaa Ser Ser Ile Ser Asp Leu Lys Glu Val Pro Arg 
                725                 730                 735     


Lys Asn Ile Xaa Leu Ile Arg Gly Leu Gly His Gly Ala Phe Gly Glu 
            740                 745                 750         


Val Tyr Glu Gly Gln Val Ser Gly Met Pro Asn Asp Pro Ser Pro Leu 
        755                 760                 765             


Gln Val Ala Val Lys Xaa Leu Pro Glu Val Cys Ser Glu Gln Asp Glu 
    770                 775                 780                 


Leu Asp Phe Leu Met Glu Ala Leu Ile Ile Ser Lys Phe Asn His Gln 
785                 790                 795                 800 


Asn Ile Val Arg Cys Ile Gly Val Ser Leu Gln Ser Leu Pro Arg Phe 
                805                 810                 815     


Ile Leu Leu Glu Leu Met Ala Gly Gly Asp Leu Lys Ser Phe Leu Arg 
            820                 825                 830         


Glu Xaa Arg Pro Arg Pro Ser Gln Pro Ser Ser Leu Ala Met Leu Asp 
        835                 840                 845             


Leu Leu His Val Ala Arg Asp Ile Ala Cys Gly Cys Gln Tyr Leu Glu 
    850                 855                 860                 


Glu Asn His Phe Ile His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu 
865                 870                 875                 880 


Xaa Cys Pro Gly Pro Gly Arg Val Ala Lys Ile Gly Asp Phe Gly Met 
                885                 890                 895     


Ala Arg Asp Ile Tyr Arg Ala Ser Tyr Tyr Arg Lys Gly Gly Cys Ala 
            900                 905                 910         


Met Leu Pro Val Lys Trp Met Pro Pro Glu Ala Phe Met Glu Gly Ile 
        915                 920                 925             


Phe Xaa Ser Lys Xaa Asp Xaa Trp Ser Phe Gly Val Leu Leu Trp Glu 
    930                 935                 940                 


Ile Phe Ser Leu Gly Tyr Met Pro Tyr Pro Ser Lys Ser Asn Gln Glu 
945                 950                 955                 960 


Val Leu Glu Phe Val Xaa Ser Gly Gly Arg Met Asp Pro Pro Lys Asn 
                965                 970                 975     


Cys Pro Gly Pro Val Tyr Arg Ile Met Xaa Gln Cys Trp Gln His Gln 
            980                 985                 990         


Pro Glu Asp Arg Pro Asn Phe Ala  Ile Ile Leu Glu Arg  Ile Glu Tyr 
        995                 1000                 1005             


Cys Xaa  Gln Asp Pro Asp Val  Ile Asn Xaa Ala Leu  Pro Ile Glu 
    1010                 1015                 1020             


Tyr Gly  Pro Leu Val Glu Glu  Glu Glu Lys Val Pro  Val Arg Pro 
    1025                 1030                 1035             


Lys Asp  Pro Glu Gly Val Pro  Pro Leu Leu Val Ser  Gln Gln Ala 
    1040                 1045                 1050             


Lys Arg  Glu Glu Glu Arg Ser  Pro Ala Ala Pro Pro  Pro Leu Pro 
    1055                 1060                 1065             


Xaa Xaa  Ser Ser Gly Lys Ala  Ala Lys Lys Pro Xaa  Ala Ala Glu 
    1070                 1075                 1080             


Ile Ser  Val Arg Val Pro Arg  Gly Pro Ala Val Glu  Gly Gly His 
    1085                 1090                 1095             


Val Asn  Met Ala Phe Ser Gln  Ser Asn Pro Pro Ser  Glu Leu His 
    1100                 1105                 1110             


Lys Val  His Gly Ser Arg Asn  Lys Pro Xaa Ser Leu  Trp Asn Pro 
    1115                 1120                 1125             


Xaa Tyr  Gly Ser Trp Phe Xaa  Glu Lys Pro Xaa Lys  Lys Asn Asn 
    1130                 1135                 1140             


Pro Ile  Ala Lys Lys Glu Pro  His Asp Arg Gly Asn  Leu Gly Leu 
    1145                 1150                 1155             


Glu Gly  Ser Cys Xaa Val Pro  Pro Asn Val Ala Xaa  Gly Arg Leu 
    1160                 1165                 1170             


Pro Gly  Ala Ser Leu Leu Leu  Glu Pro Ser Ser Leu  Xaa Ala Asn 
    1175                 1180                 1185             


Met Lys  Glu Val Pro Leu Phe  Arg Leu Arg His Phe  Pro Cys Gly 
    1190                 1195                 1200             


Asn Val  Asn Tyr Gly Tyr Gln  Gln Gln Gly Leu Pro  Leu Glu Ala 
    1205                 1210                 1215             


Ala Xaa  Ala Pro Gly Ala Gly  His Tyr Glu Asp Xaa  Ile Leu Lys 
    1220                 1225                 1230             


Ser Lys  Asn Ser Met Asn Gln  Pro Gly Pro 
    1235                 1240             


<210> 2207
<211> 580
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<400> 2207
Met Val Xaa Xaa Cys Ser Ala Ile Tyr Xaa Phe Gln Phe Ile Arg Ser 
1               5                   10                  15      


Ser Val Tyr Arg Arg Lys His Gln Glu Leu Gln Ala Met Gln Met Glu 
            20                  25                  30          


Leu Gln Ser Pro Glu Tyr Lys Leu Ser Lys Leu Arg Xaa Ser Xaa Ile 
        35                  40                  45              


Met Xaa Asp Tyr Asn Pro Asn Tyr Cys Phe Ala Gly Lys Xaa Ser Ser 
    50                  55                  60                  


Ile Ser Asp Leu Lys Glu Val Pro Arg Lys Asn Ile Xaa Leu Ile Arg 
65                  70                  75                  80  


Gly Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu Gly Gln Val Ser 
                85                  90                  95      


Gly Met Pro Asn Asp Pro Ser Pro Leu Gln Val Ala Val Lys Xaa Leu 
            100                 105                 110         


Pro Glu Val Cys Ser Glu Gln Asp Glu Leu Asp Phe Leu Met Glu Ala 
        115                 120                 125             


Leu Ile Ile Ser Lys Phe Asn His Gln Asn Ile Val Arg Cys Ile Gly 
    130                 135                 140                 


Val Ser Leu Gln Ser Leu Pro Arg Phe Ile Leu Leu Glu Leu Met Ala 
145                 150                 155                 160 


Gly Gly Asp Leu Lys Ser Phe Leu Arg Glu Xaa Arg Pro Arg Pro Ser 
                165                 170                 175     


Gln Pro Ser Ser Leu Ala Met Leu Asp Leu Leu His Val Ala Arg Asp 
            180                 185                 190         


Ile Ala Cys Gly Cys Gln Tyr Leu Glu Glu Asn His Phe Ile His Arg 
        195                 200                 205             


Asp Ile Ala Ala Arg Asn Cys Leu Leu Xaa Cys Pro Gly Pro Gly Arg 
    210                 215                 220                 


Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp Ile Tyr Arg Ala 
225                 230                 235                 240 


Ser Tyr Tyr Arg Lys Gly Gly Cys Ala Met Leu Pro Val Lys Trp Met 
                245                 250                 255     


Pro Pro Glu Ala Phe Met Glu Gly Ile Phe Xaa Ser Lys Xaa Asp Xaa 
            260                 265                 270         


Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly Tyr Met 
        275                 280                 285             


Pro Tyr Pro Ser Lys Ser Asn Gln Glu Val Leu Glu Phe Val Xaa Ser 
    290                 295                 300                 


Gly Gly Arg Met Asp Pro Pro Lys Asn Cys Pro Gly Pro Val Tyr Arg 
305                 310                 315                 320 


Ile Met Xaa Gln Cys Trp Gln His Gln Pro Glu Asp Arg Pro Asn Phe 
                325                 330                 335     


Ala Ile Ile Leu Glu Arg Ile Glu Tyr Cys Xaa Gln Asp Pro Asp Val 
            340                 345                 350         


Ile Asn Xaa Ala Leu Pro Ile Glu Tyr Gly Pro Leu Val Glu Glu Glu 
        355                 360                 365             


Glu Lys Val Pro Val Arg Pro Lys Asp Pro Glu Gly Val Pro Pro Leu 
    370                 375                 380                 


Leu Val Ser Gln Gln Ala Lys Arg Glu Glu Glu Arg Ser Pro Ala Ala 
385                 390                 395                 400 


Pro Pro Pro Leu Pro Xaa Xaa Ser Ser Gly Lys Ala Ala Lys Lys Pro 
                405                 410                 415     


Xaa Ala Ala Glu Ile Ser Val Arg Val Pro Arg Gly Pro Ala Val Glu 
            420                 425                 430         


Gly Gly His Val Asn Met Ala Phe Ser Gln Ser Asn Pro Pro Ser Glu 
        435                 440                 445             


Leu His Lys Val His Gly Ser Arg Asn Lys Pro Xaa Ser Leu Trp Asn 
    450                 455                 460                 


Pro Xaa Tyr Gly Ser Trp Phe Xaa Glu Lys Pro Xaa Lys Lys Asn Asn 
465                 470                 475                 480 


Pro Ile Ala Lys Lys Glu Pro His Asp Arg Gly Asn Leu Gly Leu Glu 
                485                 490                 495     


Gly Ser Cys Xaa Val Pro Pro Asn Val Ala Xaa Gly Arg Leu Pro Gly 
            500                 505                 510         


Ala Ser Leu Leu Leu Glu Pro Ser Ser Leu Xaa Ala Asn Met Lys Glu 
        515                 520                 525             


Val Pro Leu Phe Arg Leu Arg His Phe Pro Cys Gly Asn Val Asn Tyr 
    530                 535                 540                 


Gly Tyr Gln Gln Gln Gly Leu Pro Leu Glu Ala Ala Xaa Ala Pro Gly 
545                 550                 555                 560 


Ala Gly His Tyr Glu Asp Xaa Ile Leu Lys Ser Lys Asn Ser Met Asn 
                565                 570                 575     


Gln Pro Gly Pro 
            580 


<210> 2208
<211> 152
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<400> 2208
Ser Ser Ile Ser Asp Leu Lys Glu Val Pro Arg Lys Asn Ile Xaa Leu 
1               5                   10                  15      


Ile Arg Gly Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu Gly Gln 
            20                  25                  30          


Val Ser Gly Met Pro Asn Asp Pro Ser Pro Leu Gln Val Ala Val Lys 
        35                  40                  45              


Xaa Leu Pro Glu Val Cys Ser Glu Gln Asp Glu Leu Asp Phe Leu Met 
    50                  55                  60                  


Glu Ala Leu Ile Ile Ser Leu Ser Trp Lys Gln Leu Phe Cys Phe Xaa 
65                  70                  75                  80  


Phe Cys Leu Arg Pro Ser Trp Glu Lys Ser Xaa Met Asn Ser Ser Xaa 
                85                  90                  95      


Gln Ser Xaa His Gln Tyr Leu Arg Lys Xaa Leu Ser Cys Pro Leu Arg 
            100                 105                 110         


His Phe Leu Xaa Gln Val Pro Glu Gln His Pro His Ser Ser Ser His 
        115                 120                 125             


Ser Pro Ala Asn Gly Xaa Pro Val Glu Pro Ala Val Val Leu Pro Xaa 
    130                 135                 140                 


Cys Ser Pro Ala Arg Phe Trp Val 
145                 150         


<210> 2209
<211> 3859
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1138)..(1138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1190)..(1190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1235)..(1235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1278)..(1278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1282)..(1282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1324)..(1324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1354)..(1354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1375)..(1375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1377)..(1377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1379)..(1379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1402)..(1402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1419)..(1419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1432)..(1432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1465)..(1465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1470)..(1470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1512)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1517)..(1517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1560)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1565)..(1565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1567)..(1567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1569)..(1569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1604)..(1604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1608)..(1608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1626)..(1626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1655)..(1655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1663)..(1663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1678)..(1678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1702)..(1702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1704)..(1704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1732)..(1732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1749)..(1749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1753)..(1753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1755)..(1755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1762)..(1762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1779)..(1779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1796)..(1796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1800)..(1800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1802)..(1802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1804)..(1804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1824)..(1824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1841)..(1841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1869)..(1869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1872)..(1872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1886)..(1886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1914)..(1914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1931)..(1931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1935)..(1935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1961)..(1961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1978)..(1978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2000)..(2000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2009)..(2009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2015)..(2015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2029)..(2029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2038)..(2038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2042)..(2042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2051)..(2051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2081)..(2081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2085)..(2085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2115)..(2115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2123)..(2123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2132)..(2132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2136)..(2136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2162)..(2162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2179)..(2179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2183)..(2183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2188)..(2188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2258)..(2258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2264)..(2264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2309)..(2309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2323)..(2323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2338)..(2338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2340)..(2340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2357)..(2358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2377)..(2377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2398)..(2398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2409)..(2409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2454)..(2454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2457)..(2457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2553)..(2554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2589)..(2589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2591)..(2591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2613)..(2613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2712)..(2713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2716)..(2716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2737)..(2737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2743)..(2743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2755)..(2755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2768)..(2768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2786)..(2786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2818)..(2818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2826)..(2826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2843)..(2843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2853)..(2853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2871)..(2871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2873)..(2873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3018)..(3018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3029)..(3029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3036)..(3036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3050)..(3050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3055)..(3055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3063)..(3063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3089)..(3089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3098)..(3098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3103)..(3103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3137)..(3137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3139)..(3139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3144)..(3144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3154)..(3154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3174)..(3174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3187)..(3187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3202)..(3202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3205)..(3206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3212)..(3212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3254)..(3254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3259)..(3259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3274)..(3274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3295)..(3296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3319)..(3319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3327)..(3327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3343)..(3343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3368)..(3368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3384)..(3384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3388)..(3388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3403)..(3403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3429)..(3429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3433)..(3433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3443)..(3443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3472)..(3473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3538)..(3538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3540)..(3540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3543)..(3543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3562)..(3563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3587)..(3587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3591)..(3592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3595)..(3595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3641)..(3641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3650)..(3650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3689)..(3689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3733)..(3733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3747)..(3747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3749)..(3751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3757)..(3758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3760)..(3760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3767)..(3767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3769)..(3769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3784)..(3784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3787)..(3787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3813)..(3813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3833)..(3833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3839)..(3839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3843)..(3843)
<223> Selenocysteine

<400> 2209
Met Glu Pro Glu Asp Leu Pro Trp Pro Gly Glu Leu Glu Glu Glu Glu 
1               5                   10                  15      


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Asn Val Asp Asp Val Val Val Val Glu Glu Val Glu Glu 
        35                  40                  45              


Glu Ala Gly Arg Glu Leu Asp Ser Asp Ser His Tyr Gly Pro Gln His 
    50                  55                  60                  


Leu Glu Ser Ile Asp Asp Glu Glu Asp Glu Glu Ala Lys Ala Trp Leu 
65                  70                  75                  80  


Gln Ala His Pro Gly Arg Ile Leu Pro Pro Leu Ser Pro Pro Gln His 
                85                  90                  95      


Arg Tyr Ser Glu Gly Glu Arg Xaa Ser Leu Glu Lys Ile Val Pro Leu 
            100                 105                 110         


Xaa Cys His Val Trp Gln Gln Ile Val Tyr Gln Gly Asn Ser Arg Xaa 
        115                 120                 125             


Gln Ile Ser Asp Xaa Asn Val Val Cys Leu Glu Xaa Xaa Ala Gln Arg 
    130                 135                 140                 


Gly Ser Gly Asp Asp Gln Lys Xaa Glu Ser Trp His Cys Leu Pro Gln 
145                 150                 155                 160 


Glu Met Asp Ser Ser Gln Xaa Leu Asp Xaa Ser Gln Xaa Arg Phe Asn 
                165                 170                 175     


Val Arg Xaa Glu Asp Xaa Glu Val Xaa Asp Phe Pro Ser Leu Glu Glu 
            180                 185                 190         


Gly Ile Leu Xaa Gln Ser Glu Asn Gln Val Lys Glu Pro Asn Arg Asp 
        195                 200                 205             


Leu Phe Cys Ser Pro Leu Leu Val Ile Gln Asp Ser Phe Ala Ser Pro 
    210                 215                 220                 


Asp Leu Pro Leu Leu Xaa Cys Leu Xaa Gln Asp Gln Glu Phe Ala Pro 
225                 230                 235                 240 


Asp Ser Leu Phe His Gln Ser Glu Leu Ser Phe Ala Pro Leu Arg Gly 
                245                 250                 255     


Ile Pro Asp Lys Ser Glu Asp Xaa Glu Trp Ser Ser Arg Pro Ser Glu 
            260                 265                 270         


Val Ser Glu Ala Leu Phe Gln Ala Xaa Ala Glu Val Ala Ser Asp Leu 
        275                 280                 285             


Ala Ser Ser Arg Phe Ser Val Ser Gln His Pro Leu Ile Gly Ser Xaa 
    290                 295                 300                 


Ala Val Gly Ser Gln Cys Pro Phe Leu Pro Ser Glu Gln Gly Asn Asn 
305                 310                 315                 320 


Glu Glu Xaa Ile Ser Ser Val Asp Glu Leu Lys Ile Pro Lys Asp Cys 
                325                 330                 335     


Asp Arg Tyr Asp Asp Leu Cys Ser Tyr Met Ser Trp Lys Xaa Arg Lys 
            340                 345                 350         


Asp Xaa Gln Trp Pro Glu Asn Asn Leu Ala Asp Lys Asp Gln Val Ser 
        355                 360                 365             


Val Ala Xaa Ser Phe Asp Ile Xaa Asp Glu Asn Ile Ala Xaa Lys Arg 
    370                 375                 380                 


Ser Asp His Phe Asp Ala Ala Arg Ser Tyr Gly Gln Tyr Trp Xaa Gln 
385                 390                 395                 400 


Glu Asp Ser Ser Lys Gln Ala Glu Xaa Tyr Leu Xaa Lys Gly Leu Gln 
                405                 410                 415     


Gly Lys Val Glu Ser Asp Val Ile Xaa Leu Asp Gly Leu Asn Glu Asn 
            420                 425                 430         


Ala Val Val Cys Ser Glu Arg Val Ala Glu Leu Gln Arg Lys Pro Xaa 
        435                 440                 445             


Arg Glu Ser Glu Tyr His Ser Ser Asp Leu Arg Met Leu Arg Met Ser 
    450                 455                 460                 


Pro Asp Xaa Val Pro Lys Ala Pro Lys His Leu Lys Ala Gly Asp Xaa 
465                 470                 475                 480 


Ser Lys Gly Gly Ile Ala Lys Val Xaa Gln Ser Asn Leu Lys Ser Gly 
                485                 490                 495     


Ile Xaa Xaa Xaa Pro Val Asp Ser Asp Ile Gly Ser His Leu Ser Leu 
            500                 505                 510         


Ser Leu Glu Asp Leu Ser Gln Leu Ala Val Ser Ser Pro Leu Glu Xaa 
        515                 520                 525             


Xaa Xaa Gly Gln His Xaa Asp Xaa Leu Asn Gln Lys Xaa Leu Ala Asp 
    530                 535                 540                 


Xaa His Leu Xaa Glu Glu Xaa Leu Lys Val Xaa Ala Ile Pro Glu Pro 
545                 550                 555                 560 


Ala Asp Gln Lys Xaa Ala Xaa Pro Xaa Val Leu Ser Ser Ser His Ser 
                565                 570                 575     


His Arg Gly Lys Pro Ser Ile Phe Tyr Gln Gln Gly Leu Pro Asp Ser 
            580                 585                 590         


His Leu Xaa Glu Glu Ala Leu Lys Val Ser Ala Ala Pro Gly Leu Ala 
        595                 600                 605             


Asp Gln Xaa Xaa Gly Met Ser Xaa Leu Xaa Ser Xaa Ser Tyr Ser His 
    610                 615                 620                 


Arg Glu Lys Pro Gly Xaa Phe Tyr Gln Gln Glu Leu Pro Glu Ser Asn 
625                 630                 635                 640 


Leu Xaa Glu Glu Pro Leu Glu Val Ser Ala Ala Pro Gly Pro Val Glu 
                645                 650                 655     


Gln Lys Xaa Gly Ile Pro Xaa Val Ser Ser Xaa Ser His Ser His Val 
            660                 665                 670         


Glu Asp Leu Leu Phe Phe Tyr Arg Gln Xaa Leu Pro Asp Gly His Leu 
        675                 680                 685             


Xaa Asp Gln Ala Leu Lys Val Ser Ala Val Ser Gly Pro Ala Asp Gln 
    690                 695                 700                 


Lys Xaa Gly Xaa Ala Xaa Val Leu Ser Xaa Pro His Ser His Arg Glu 
705                 710                 715                 720 


Lys Pro Gly Ile Phe Tyr Gln Gln Glu Phe Ala Asp Ser His Gln Xaa 
                725                 730                 735     


Glu Glu Xaa Leu Xaa Lys Val Ser Ala Xaa Pro Gly Pro Ala Asp Gln 
            740                 745                 750         


Lys Xaa Glu Ile Pro Ala Val Gln Ser Ser Ser Tyr Ser Gln Arg Glu 
        755                 760                 765             


Lys Pro Ser Ile Leu Tyr Pro Gln Asp Leu Ala Asp Ser His Leu Pro 
    770                 775                 780                 


Glu Glu Gly Leu Lys Val Ser Ala Val Ala Gly Pro Ala Asp Gln Lys 
785                 790                 795                 800 


Xaa Gly Leu Pro Xaa Val Pro Ser Ser Ala Tyr Ser His Arg Glu Lys 
                805                 810                 815     


Leu Leu Val Phe Tyr Gln Gln Ala Leu Leu Asp Ser His Leu Pro Glu 
            820                 825                 830         


Glu Ala Leu Lys Val Ser Ala Val Ser Gly Pro Ala Asp Gly Lys Xaa 
        835                 840                 845             


Gly Xaa Pro Ala Val Xaa Ser Xaa Ser Ser Ala Ser Ser Ser Leu Gly 
    850                 855                 860                 


Glu Lys Pro Ser Ala Phe Tyr Gln Gln Xaa Leu Pro Asn Ser His Leu 
865                 870                 875                 880 


Xaa Glu Glu Ala Leu Lys Val Ser Ile Val Pro Gly Pro Gly Asp Gln 
                885                 890                 895     


Lys Xaa Gly Ile Pro Ser Ala Pro Ser Ser Phe Tyr Ser His Arg Glu 
            900                 905                 910         


Lys Pro Ile Ile Phe Ser Gln Gln Xaa Leu Pro Asp Phe Leu Phe Pro 
        915                 920                 925             


Glu Glu Ala Leu Lys Val Ser Ala Val Ser Val Leu Ala Ala Gln Lys 
    930                 935                 940                 


Xaa Gly Xaa Pro Xaa Val Ser Ser Asn Ser His Ser His Ser Glu Lys 
945                 950                 955                 960 


Ser Ser Val Phe Tyr Gln Gln Glu Leu Pro Asp Ser Asp Leu Pro Arg 
                965                 970                 975     


Glu Ser Leu Lys Met Ser Ala Ile Pro Gly Leu Xaa Asp Gln Lys Xaa 
            980                 985                 990         


Val Pro Xaa Pro Xaa Val Pro Ser  Gly Ser Phe Ser His  Arg Glu Lys 
        995                 1000                 1005             


Pro Ser  Ile Phe Tyr Gln Gln  Glu Trp Pro Asp Ser  Tyr Ala Xaa 
    1010                 1015                 1020             


Glu Lys  Ala Leu Lys Val Ser  Xaa Gly Pro Gly Pro  Ala Asp Gln 
    1025                 1030                 1035             


Lys Xaa  Glu Ile Pro Ala Val  Gln Ser Ser Ser Tyr  Pro Gln Arg 
    1040                 1045                 1050             


Glu Lys  Pro Ser Val Leu Tyr  Pro Gln Val Leu Ser  Asp Ser His 
    1055                 1060                 1065             


Leu Pro  Glu Glu Ser Leu Lys  Val Ser Ala Phe Pro  Gly Pro Ala 
    1070                 1075                 1080             


Asp Gln  Met Xaa Asp Xaa Pro  Ala Val Pro Ser Xaa  Phe Tyr Ser 
    1085                 1090                 1095             


Gln Arg  Glu Lys Pro Gly Ile  Phe Tyr Gln Gln Xaa  Leu Pro Glu 
    1100                 1105                 1110             


Ser His  Leu Pro Lys Glu Ala  Leu Lys Ile Ser Val  Ala Pro Gly 
    1115                 1120                 1125             


Leu Ala  Asp Gln Lys Xaa Gly  Xaa Pro Xaa Val Xaa  Ser Xaa Ser 
    1130                 1135                 1140             


Tyr Ser  Gln His Arg Glu Lys  Pro Ser Ile Phe His  Gln Gln Ala 
    1145                 1150                 1155             


Leu Pro  Gly Xaa His Ile Pro  Glu Glu Ala Gln Lys  Val Ser Ala 
    1160                 1165                 1170             


Val Xaa  Gly Pro Gly Asn Gln  Lys Xaa Trp Ile Pro  Arg Val Leu 
    1175                 1180                 1185             


Ser Xaa  Phe Tyr Ser Gln Arg  Glu Lys Pro Gly Ile  Phe Tyr Gln 
    1190                 1195                 1200             


Gln Xaa  Leu Pro Gly Ser His  Ile Pro Glu Glu Ala  Gln Lys Val 
    1205                 1210                 1215             


Ser Pro  Val Leu Gly Pro Ala  Asp Gln Lys Xaa Gly  Xaa Pro Xaa 
    1220                 1225                 1230             


Pro Xaa  Ser Ala Ser Tyr Ser  His Xaa Glu Lys Pro  Gly Ile Phe 
    1235                 1240                 1245             


Tyr Gln  Gln Val Leu Pro Asp  Asn His Pro Xaa Glu  Glu Ala Leu 
    1250                 1255                 1260             


Lys Ile  Ser Val Ala Ser Glu  Pro Val Asp Gln Xaa  Xaa Gly Xaa 
    1265                 1270                 1275             


Pro Ala  Val Xaa Ser Xaa Ser  Tyr Ser Gln Tyr Arg  Glu Lys Pro 
    1280                 1285                 1290             


Ser Ile  Phe Tyr Gln Gln Ser  Leu Pro Ser Ser His  Leu Xaa Glu 
    1295                 1300                 1305             


Glu Ala  Lys Asn Val Ser Ala  Val Pro Gly Pro Ala  Asp Gln Lys 
    1310                 1315                 1320             


Xaa Val  Ile Pro Ile Leu Pro  Ser Xaa Phe Tyr Ser  His Xaa Glu 
    1325                 1330                 1335             


Lys Pro  Gly Val Phe Tyr Gln  Gln Val Leu Pro His  Ser His Pro 
    1340                 1345                 1350             


Xaa Glu  Glu Ala Leu Lys Ile  Ser Val Ala Ser Glu  Pro Val Asp 
    1355                 1360                 1365             


Gln Xaa  Xaa Gly Xaa Pro Xaa  Val Xaa Ser Xaa Ser  Tyr Ser Gln 
    1370                 1375                 1380             


His Xaa  Glu Lys Pro Ser Ile  Phe Tyr Gln Gln Ser  Leu Pro Gly 
    1385                 1390                 1395             


Ser His  Leu Xaa Glu Glu Ala  Lys Asn Val Ser Ala  Val Pro Gly 
    1400                 1405                 1410             


Pro Gly  Asp Arg Lys Xaa Gly  Ile Pro Xaa Leu Pro  Ser Xaa Phe 
    1415                 1420                 1425             


Tyr Ser  His Xaa Glu Lys Pro  Gly Ser Phe Tyr Gln  Gln Val Leu 
    1430                 1435                 1440             


Pro His  Ser His Leu Pro Glu  Glu Ala Leu Glu Val  Ser Val Ala 
    1445                 1450                 1455             


Pro Gly  Pro Val Asp Gln Xaa  Ile Gly Xaa Pro Xaa  Val Xaa Ser 
    1460                 1465                 1470             


Pro Ser  Ser Ser Phe Gly Glu  Lys Pro Ile Val Ile  Tyr Lys Gln 
    1475                 1480                 1485             


Ala Phe  Pro Glu Gly His Leu  Pro Glu Glu Ser Leu  Lys Val Ser 
    1490                 1495                 1500             


Val Ala  Pro Gly Pro Val Gly  Gln Xaa Xaa Gly Ala  Pro Xaa Ile 
    1505                 1510                 1515             


Xaa Ser  Pro Ser Tyr Ser Gln  His Arg Ala Lys Ser  Gly Ser Phe 
    1520                 1525                 1530             


Tyr Gln  Leu Ala Leu Leu Gly  Ser Gln Ile Pro Glu  Glu Ala Leu 
    1535                 1540                 1545             


Arg Val  Ser Ser Ala Pro Gly  Pro Ala Asp Gln Xaa  Xaa Gly Ile 
    1550                 1555                 1560             


Pro Xaa  Ile Xaa Ser Xaa Ser  Tyr Ser Phe Gly Glu  Lys Pro Ile 
    1565                 1570                 1575             


Val Asn  Tyr Lys Gln Ala Phe  Pro Asp Gly His Leu  Pro Glu Glu 
    1580                 1585                 1590             


Ala Leu  Lys Val Ser Ile Val  Ser Gly Pro Xaa Glu  Lys Lys Xaa 
    1595                 1600                 1605             


Asp Ile  Pro Ala Gly Pro Leu  Gly Ser Ser Ala Leu  Gly Glu Lys 
    1610                 1615                 1620             


Pro Ile  Xaa Phe Tyr Arg Gln  Ala Leu Leu Asp Ser  Pro Leu Asn 
    1625                 1630                 1635             


Lys Glu  Val Val Lys Val Ser  Ala Ala Pro Gly Pro  Ala Asp Gln 
    1640                 1645                 1650             


Lys Xaa  Glu Xaa Leu Pro Val  His Ser Xaa Ser Tyr  Ser Asn Arg 
    1655                 1660                 1665             


Gly Lys  Pro Val Ile Phe Tyr  Gln Gln Xaa Leu Ser  Asp Ser His 
    1670                 1675                 1680             


Leu Pro  Glu Glu Ala Leu Lys  Val Pro Pro Val Pro  Gly Pro Asp 
    1685                 1690                 1695             


Ala Gln  Lys Xaa Glu Xaa Pro  Ser Val Ser Ser Ser  Leu Tyr Ser 
    1700                 1705                 1710             


Tyr Arg  Glu Lys Pro Ile Val  Phe Tyr Gln Gln Ala  Leu Pro Asp 
    1715                 1720                 1725             


Ser Glu  Leu Xaa Gln Glu Ala  Leu Lys Val Ser Ala  Val Pro Gln 
    1730                 1735                 1740             


Pro Ala  Asp Gln Lys Xaa Gly  Leu Ser Xaa Val Xaa  Ser Ser Phe 
    1745                 1750                 1755             


Tyr Ser  His Xaa Glu Lys Pro  Asn Ile Ser Tyr Gln  Gln Glu Leu 
    1760                 1765                 1770             


Pro Asp  Ser His Leu Xaa Glu  Glu Ala Leu Lys Val  Ser Asn Val 
    1775                 1780                 1785             


Pro Gly  Pro Ala Asp Gln Lys  Xaa Gly Val Ser Xaa  Val Xaa Ser 
    1790                 1795                 1800             


Xaa Ser  Tyr Ser His Arg Glu  Lys Pro Ile Val Ser  Tyr Gln Arg 
    1805                 1810                 1815             


Glu Leu  Pro His Phe Xaa Glu  Ala Gly Leu Lys Ile  Leu Arg Val 
    1820                 1825                 1830             


Pro Gly  Pro Ala Asp Gln Lys  Xaa Gly Ile Asn Ile  Leu Pro Ser 
    1835                 1840                 1845             


Asn Ser  Tyr Pro Gln Arg Glu  His Ser Val Ile Ser  Tyr Glu Gln 
    1850                 1855                 1860             


Glu Leu  Pro Asp Leu Xaa Glu  Val Xaa Leu Lys Ala  Ile Gly Val 
    1865                 1870                 1875             


Pro Gly  Pro Ala Asp Gln Lys  Xaa Gly Ile Gln Ile  Ala Ser Ser 
    1880                 1885                 1890             


Ser Ser  Tyr Ser Asn Arg Glu  Lys Ala Ser Ile Phe  His Gln Gln 
    1895                 1900                 1905             


Glu Leu  Pro Asp Val Xaa Glu  Glu Ala Leu Asn Val  Phe Val Val 
    1910                 1915                 1920             


Pro Gly  Gln Gly Asp Arg Lys  Xaa Glu Ile Pro Xaa  Val Pro Leu 
    1925                 1930                 1935             


Ser Tyr  Tyr Ser Arg Arg Glu  Lys Pro Ser Val Ile  Ser Gln Gln 
    1940                 1945                 1950             


Glu Leu  Pro Asp Ser His Leu  Xaa Glu Glu Ala Leu  Lys Val Ser 
    1955                 1960                 1965             


Pro Val  Ser Ile Pro Ala Glu  Gln Lys Xaa Gly Ile  Pro Ile Gly 
    1970                 1975                 1980             


Leu Ser  Ser Ser Tyr Ser His  Ser His Lys Glu Lys  Leu Lys Ile 
    1985                 1990                 1995             


Ser Xaa  Val His Ile Pro Asp  Asp Gln Lys Xaa Glu  Phe Pro Ala 
    2000                 2005                 2010             


Ala Xaa  Leu Ser Ser Tyr Ser  Gln Ile Glu Lys Pro  Lys Ile Ser 
    2015                 2020                 2025             


Xaa Val  Ile Gly Pro Asn Asp  Gln Lys Xaa Pro Ser  Gln Xaa Ala 
    2030                 2035                 2040             


Phe His  Ser Ser Tyr Ser Gln  Xaa Val Lys Pro Asn  Ile Leu Phe 
    2045                 2050                 2055             


Gln Gln  Gln Leu Pro Asp Arg  Asp Gln Ser Lys Gly  Ile Leu Lys 
    2060                 2065                 2070             


Ile Ser  Ala Val Pro Glu Leu  Xaa Asp Val Asn Xaa  Gly Lys Pro 
    2075                 2080                 2085             


Val Ser  Leu Ser Ser Ser Tyr  Phe His Arg Glu Lys  Ser Asn Ile 
    2090                 2095                 2100             


Phe Ser  Pro Gln Glu Leu Pro  Gly Ser His Val Xaa  Glu Asp Val 
    2105                 2110                 2115             


Leu Lys  Val Ser Xaa Ile Pro  Gly Pro Ala Gly Gln  Lys Xaa Val 
    2120                 2125                 2130             


Leu Pro  Xaa Ala Leu Pro Ser  Ser Phe Ser His Arg  Glu Lys Pro 
    2135                 2140                 2145             


Asp Ile  Phe Tyr Gln Lys Asp  Leu Pro Asp Arg His  Leu Xaa Glu 
    2150                 2155                 2160             


Asp Ala  Leu Lys Ile Ser Ser  Ala Leu Gly Gln Ala  Asp Gln Ile 
    2165                 2170                 2175             


Xaa Gly  Leu Gln Xaa Val Pro  Ser Gly Xaa Tyr Ser  His Gly Glu 
    2180                 2185                 2190             


Asn His  Lys Leu Val Ser Glu  His Val Gln Arg Leu  Ile Asp Asn 
    2195                 2200                 2205             


Leu Asn  Ser Ser Asp Ser Ser  Val Ser Ser Asn Asn  Val Leu Leu 
    2210                 2215                 2220             


Asn Ser  Gln Ala Asp Asp Arg  Val Val Ile Asn Lys  Pro Glu Ser 
    2225                 2230                 2235             


Ala Gly  Phe Arg Asp Val Gly  Ser Glu Glu Ile Gln  Asp Ala Glu 
    2240                 2245                 2250             


Asn Ser  Ala Lys Xaa Leu Lys  Glu Ile Arg Xaa Leu  Leu Met Glu 
    2255                 2260                 2265             


Ala Glu  Asn Met Ala Leu Lys  Arg Cys Asn Phe Pro  Ala Pro Leu 
    2270                 2275                 2280             


Ala Arg  Phe Arg Asp Ile Ser  Asp Ile Ser Phe Ile  Gln Ser Lys 
    2285                 2290                 2295             


Lys Val  Val Cys Phe Lys Glu  Pro Ser Ser Xaa Gly  Val Ser Asn 
    2300                 2305                 2310             


Gly Asp  Leu Leu His Arg Gln  Pro Phe Xaa Glu Glu  Ser Pro Ser 
    2315                 2320                 2325             


Ser Arg  Cys Ile Gln Lys Asp  Ile Gly Xaa Gln Xaa  Asn Leu Lys 
    2330                 2335                 2340             


Cys Arg  Arg Gly Ile Glu Asn  Trp Glu Phe Ile Ser  Ser Xaa Xaa 
    2345                 2350                 2355             


Val Arg  Ser Pro Leu Gln Glu  Ala Glu Ser Lys Val  Ser Met Ala 
    2360                 2365                 2370             


Leu Glu  Glu Xaa Leu Arg Gln  Tyr Gln Ala Ala Lys  Ser Val Met 
    2375                 2380                 2385             


Arg Ser  Glu Pro Glu Gly Cys  Ser Gly Xaa Ile Gly  Asn Lys Ile 
    2390                 2395                 2400             


Ile Ile  Pro Met Met Xaa Val  Ile Lys Ser Asp Ser  Ser Ser Asp 
    2405                 2410                 2415             


Ala Ser  Asp Gly Asn Gly Ser  Cys Ser Trp Asp Ser  Asn Leu Pro 
    2420                 2425                 2430             


Glu Ser  Leu Glu Ser Val Ser  Asp Val Leu Leu Asn  Phe Phe Pro 
    2435                 2440                 2445             


Tyr Val  Ser Pro Lys Xaa Ser  Ile Xaa Asp Ser Arg  Glu Glu Glu 
    2450                 2455                 2460             


Gly Val  Ser Glu Ser Glu Asp  Gly Gly Gly Ser Ser  Val Asp Ser 
    2465                 2470                 2475             


Leu Ala  Ala His Val Lys Asn  Leu Leu Gln Cys Glu  Ser Ser Leu 
    2480                 2485                 2490             


Asn His  Ala Lys Glu Ile Leu  Arg Asn Ala Glu Glu  Glu Glu Ser 
    2495                 2500                 2505             


Arg Val  Arg Ala His Ala Trp  Asn Met Lys Phe Asn  Leu Ala His 
    2510                 2515                 2520             


Asp Cys  Gly Tyr Ser Ile Ser  Glu Leu Asn Glu Asp  Asp Arg Arg 
    2525                 2530                 2535             


Lys Val  Glu Glu Ile Lys Ala  Glu Leu Phe Gly His  Gly Arg Xaa 
    2540                 2545                 2550             


Xaa Asp  Leu Ser Lys Gly Leu  Gln Ser Pro Arg Gly  Met Gly Cys 
    2555                 2560                 2565             


Lys Pro  Glu Ala Val Cys Ser  His Ile Ile Ile Glu  Ser His Glu 
    2570                 2575                 2580             


Lys Gly  Cys Phe Arg Xaa Leu  Xaa Ser Glu His Pro  Gln Leu Asp 
    2585                 2590                 2595             


Arg His  Pro Cys Ala Phe Arg  Ser Ala Gly Pro Ser  Glu Met Xaa 
    2600                 2605                 2610             


Arg Gly  Arg Gln Asn Pro Ser  Ser Cys Arg Ala Lys  His Val Asn 
    2615                 2620                 2625             


Leu Ser  Ala Ser Leu Asp Gln  Asn Asn Ser His Phe  Lys Val Trp 
    2630                 2635                 2640             


Asn Ser  Leu Gln Leu Lys Ser  His Ser Pro Phe Gln  Asn Phe Ile 
    2645                 2650                 2655             


Pro Asp  Glu Phe Lys Ile Ser  Lys Gly Leu Arg Met  Pro Phe Asp 
    2660                 2665                 2670             


Glu Lys  Met Asp Pro Trp Leu  Ser Glu Leu Val Glu  Pro Ala Phe 
    2675                 2680                 2685             


Val Pro  Pro Lys Glu Val Asp  Phe His Ser Ser Ser  Gln Met Pro 
    2690                 2695                 2700             


Ser Pro  Glu Pro Met Lys Lys  Phe Xaa Xaa Ser Ile  Xaa Phe Ser 
    2705                 2710                 2715             


Ser His  Arg His Ser Lys Cys  Ile Ser Asn Ser Ser  Val Val Lys 
    2720                 2725                 2730             


Val Gly  Val Xaa Glu Gly Ser  Gln Cys Xaa Gly Ala  Ser Val Gly 
    2735                 2740                 2745             


Val Phe  Asn Ser His Phe Xaa  Glu Glu Gln Asn Pro  Pro Arg Asp 
    2750                 2755                 2760             


Leu Lys  Gln Lys Xaa Ser Ser  Pro Ser Ser Phe Lys  Met His Ser 
    2765                 2770                 2775             


Asn Ser  Gln Asp Lys Glu Val  Xaa Ile Leu Ala Glu  Gly Arg Arg 
    2780                 2785                 2790             


Gln Ser  Gln Lys Leu Pro Val  Asp Phe Glu Arg Ser  Phe Gln Glu 
    2795                 2800                 2805             


Glu Lys  Pro Leu Glu Arg Ser  Asp Phe Xaa Gly Ser  His Ser Glu 
    2810                 2815                 2820             


Pro Ser  Xaa Arg Ala Asn Cys  Ser Asn Phe Lys Glu  Ile Gln Ile 
    2825                 2830                 2835             


Ser Asp  Asn His Xaa Leu Ile  Ser Met Gly Arg Pro  Ser Ser Xaa 
    2840                 2845                 2850             


Leu Gly  Val Asn Arg Ser Ser  Ser Arg Leu Gly Val  Lys Glu Lys 
    2855                 2860                 2865             


Asn Val  Xaa Ile Xaa Pro Asp  Leu Pro Ser Cys Ile  Phe Leu Glu 
    2870                 2875                 2880             


Gln Arg  Glu Leu Phe Glu Gln  Ser Lys Ala Pro Arg  Ala Asp Asp 
    2885                 2890                 2895             


His Val  Arg Lys His His Ser  Pro Ser Pro Gln His  Gln Asp Tyr 
    2900                 2905                 2910             


Val Ala  Pro Asp Leu Pro Ser  Cys Ile Phe Leu Glu  Gln Arg Glu 
    2915                 2920                 2925             


Leu Phe  Glu Gln Cys Lys Ala  Pro Tyr Val Asp His  Gln Met Arg 
    2930                 2935                 2940             


Glu Asn  His Ser Pro Leu Pro  Gln Gly Gln Asp Ser  Ile Ala Ser 
    2945                 2950                 2955             


Asp Leu  Pro Ser Pro Ile Ser  Leu Glu Gln Cys Gln  Ser Lys Ala 
    2960                 2965                 2970             


Pro Gly  Val Asp Asp Gln Met  Asn Lys His His Phe  Pro Leu Pro 
    2975                 2980                 2985             


Gln Gly  Gln Asp Cys Val Val  Glu Lys Asn Asn Gln  His Lys Pro 
    2990                 2995                 3000             


Lys Ser  His Ile Ser Asn Ile  Asn Val Glu Ala Lys  Phe Asn Xaa 
    3005                 3010                 3015             


Val Val  Ser Gln Ser Ala Pro  Asn His Cys Xaa Leu  Ala Ala Ser 
    3020                 3025                 3030             


Ala Ser  Xaa Pro Pro Ser Asn  Arg Lys Ala Leu Ser  Cys Val His 
    3035                 3040                 3045             


Ile Xaa  Leu Cys Pro Lys Xaa  Ser Ser Lys Leu Asp  Ser Gly Xaa 
    3050                 3055                 3060             


Leu Asp  Glu Arg Phe His Ser  Leu Asp Ala Ala Ser  Lys Ala Arg 
    3065                 3070                 3075             


Met Asn  Ser Glu Phe Asn Phe  Asp Leu His Xaa Val  Ser Ser Arg 
    3080                 3085                 3090             


Ser Leu  Glu Pro Xaa Ser Lys  Leu Leu Xaa Ser Lys  Pro Val Ala 
    3095                 3100                 3105             


Gln Asp  Gln Glu Ser Leu Gly  Phe Leu Gly Pro Lys  Ser Ser Leu 
    3110                 3115                 3120             


Asp Phe  Gln Val Val Gln Pro  Ser Leu Pro Asp Ser  Asn Xaa Ile 
    3125                 3130                 3135             


Xaa Gln  Asp Leu Lys Xaa Ile  Pro Ser Gln Asn Ser  Gln Ile Val 
    3140                 3145                 3150             


Xaa Ser  Arg Gln Ile Gln Val  Asn Ile Ser Asp Phe  Glu Gly His 
    3155                 3160                 3165             


Ser Asn  Pro Glu Gly Xaa Pro  Val Phe Ala Asp Arg  Leu Pro Glu 
    3170                 3175                 3180             


Lys Met  Lys Xaa Pro Leu Ser  Ala Phe Ser Glu Lys  Leu Ser Ser 
    3185                 3190                 3195             


Asp Ala  Val Xaa Gln Ile Xaa  Xaa Glu Ser Pro Glu  Lys Xaa Leu 
    3200                 3205                 3210             


Phe Ser  Ser Glu Ile Phe Ile  Asn Ala Glu Asp Arg  Gly His Glu 
    3215                 3220                 3225             


Ile Ile  Glu Pro Gly Asn Gln  Lys Leu Arg Lys Ala  Pro Val Lys 
    3230                 3235                 3240             


Phe Ala  Ser Ser Ser Ser Val  Gln Gln Val Xaa Phe  Ser Arg Gly 
    3245                 3250                 3255             


Xaa Asp  Gly Gln Pro Leu Leu  Leu Pro Tyr Lys Pro  Ser Gly Ser 
    3260                 3265                 3270             


Xaa Lys  Met Tyr Tyr Val Pro  Gln Leu Arg Gln Ile  Pro Pro Ser 
    3275                 3280                 3285             


Pro Asp  Ser Lys Ser Asp Xaa  Xaa Val Glu Ser Ser  His Ser Gly 
    3290                 3295                 3300             


Ser Asn  Asp Ala Ile Ala Pro  Asp Phe Pro Ala Gln  Val Leu Gly 
    3305                 3310                 3315             


Xaa Arg  Asp Asp Asp Leu Ser  Ala Xaa Val Asn Ile  Lys His Lys 
    3320                 3325                 3330             


Glu Gly  Ile Tyr Ser Lys Arg  Val Val Xaa Lys Ala  Ser Leu Pro 
    3335                 3340                 3345             


Val Gly  Glu Lys Pro Leu Gln  Asn Glu Asn Ala Asp  Ala Ser Val 
    3350                 3355                 3360             


Gln Val  Leu Ile Xaa Gly Asp  Glu Asn Leu Ser Asp  Lys Lys Gln 
    3365                 3370                 3375             


Gln Glu  Ile His Ser Xaa Arg  Ala Val Xaa Glu Ala  Ala Gln Ala 
    3380                 3385                 3390             


Lys Glu  Lys Glu Ser Leu Gln  Lys Asp Xaa Ala Asp  Ser Ser Ala 
    3395                 3400                 3405             


Ala Ala  Ala Ala Glu His Ser  Ala Gln Val Gly Asp  Pro Glu Met 
    3410                 3415                 3420             


Lys Asn  Leu Pro Asp Xaa Lys  Ala Ile Xaa Gln Lys  Glu Glu Ile 
    3425                 3430                 3435             


His Arg  Lys Lys Xaa Val Pro  Glu Glu Ala Trp Pro  Asn Asn Lys 
    3440                 3445                 3450             


Glu Ser  Leu Gln Ile Asn Ile  Glu Glu Ser Glu Cys  His Ser Glu 
    3455                 3460                 3465             


Phe Glu  Asn Xaa Xaa Arg Ser  Val Phe Arg Ser Ala  Lys Phe Tyr 
    3470                 3475                 3480             


Ile His  His Pro Val His Leu  Pro Ser Asp Gln Asp  Ile Cys His 
    3485                 3490                 3495             


Glu Ser  Leu Gly Lys Ser Val  Phe Met Arg His Ser  Trp Lys Asp 
    3500                 3505                 3510             


Phe Phe  Gln His His Pro Asp  Lys His Arg Glu His  Met Cys Leu 
    3515                 3520                 3525             


Pro Leu  Pro Tyr Gln Asn Met  Asp Lys Xaa Lys Xaa  Asp Tyr Xaa 
    3530                 3535                 3540             


Arg Ile  Lys Ser Leu Ser Ile  Asn Val Asn Leu Gly  Asn Lys Glu 
    3545                 3550                 3555             


Val Met  Asp Xaa Xaa Lys Ser  Gln Val Arg Asp Tyr  Pro Lys His 
    3560                 3565                 3570             


Asn Gly  Gln Ile Ser Asp Pro  Gln Arg Asp Gln Lys  Val Xaa Pro 
    3575                 3580                 3585             


Glu Gln  Xaa Xaa Gln His Xaa  Val Ser Leu Asn Glu  Leu Trp Asn 
    3590                 3595                 3600             


Lys Tyr  Arg Glu Arg Gln Arg  Gln Gln Arg Gln Pro  Glu Leu Gly 
    3605                 3610                 3615             


Asp Arg  Lys Glu Leu Ser Leu  Val Asp Arg Leu Asp  Arg Leu Ala 
    3620                 3625                 3630             


Lys Ile  Leu Gln Asn Pro Ile  Xaa His Ser Leu Gln  Val Ser Glu 
    3635                 3640                 3645             


Ser Xaa  His Asp Asp Ser Arg  Gly Glu Arg Ser Val  Lys Glu Trp 
    3650                 3655                 3660             


Ser Gly  Arg Gln Gln Gln Arg  Asn Lys Leu Gln Lys  Lys Lys Arg 
    3665                 3670                 3675             


Phe Lys  Ser Leu Glu Lys Ser  His Lys Asn Xaa Gly  Glu Leu Lys 
    3680                 3685                 3690             


Lys Ser  Lys Val Leu Ser His  His Arg Ala Gly Arg  Ser Asn Gln 
    3695                 3700                 3705             


Ile Lys  Ile Glu Gln Ile Lys  Phe Asp Lys Tyr Ile  Leu Ser Lys 
    3710                 3715                 3720             


Gln Pro  Gly Phe Asn Tyr Ile  Ser Asn Xaa Ser Ser  Asp Cys Arg 
    3725                 3730                 3735             


Pro Ser  Glu Glu Ser Glu Leu  Leu Xaa Asp Xaa Xaa  Xaa Asn Ile 
    3740                 3745                 3750             


Leu Ser  Gly Xaa Xaa Ser Xaa  Val Glu Ser Asp Ile  Leu Xaa Gln 
    3755                 3760                 3765             


Xaa Asp  Arg Glu Val Ala Leu  His Glu Arg Ser Ser  Ser Val Ser 
    3770                 3775                 3780             


Xaa Ile  Asp Xaa Ala Arg Leu  Ile Gln Ala Phe Gly  His Glu Arg 
    3785                 3790                 3795             


Val Cys  Leu Ser Pro Arg Arg  Ile Lys Leu Tyr Ser  Ser Ile Xaa 
    3800                 3805                 3810             


Asn Gln  Gln Arg Arg Tyr Leu  Glu Lys Arg Ser Lys  His Ser Lys 
    3815                 3820                 3825             


Lys Val  Leu Asn Xaa Gly His  Pro Leu Val Xaa Ser  Glu His Xaa 
    3830                 3835                 3840             


Arg Arg  Arg His Ile Gln Val  His Gly Tyr Arg Phe  His Leu Ala 
    3845                 3850                 3855             


Met 
    


<210> 2210
<211> 4168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1138)..(1138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1190)..(1190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1235)..(1235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1278)..(1278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1282)..(1282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1324)..(1324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1354)..(1354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1375)..(1375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1377)..(1377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1379)..(1379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1402)..(1402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1419)..(1419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1432)..(1432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1465)..(1465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1470)..(1470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1512)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1517)..(1517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1560)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1565)..(1565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1567)..(1567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1569)..(1569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1604)..(1604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1608)..(1608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1626)..(1626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1655)..(1655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1663)..(1663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1678)..(1678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1702)..(1702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1704)..(1704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1732)..(1732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1749)..(1749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1753)..(1753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1755)..(1755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1762)..(1762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1779)..(1779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1796)..(1796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1800)..(1800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1802)..(1802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1804)..(1804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1824)..(1824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1841)..(1841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1869)..(1869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1872)..(1872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1886)..(1886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1914)..(1914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1931)..(1931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1935)..(1935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1961)..(1961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1978)..(1978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2000)..(2000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2009)..(2009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2015)..(2015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2029)..(2029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2038)..(2038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2042)..(2042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2051)..(2051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2081)..(2081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2085)..(2085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2115)..(2115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2123)..(2123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2132)..(2132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2136)..(2136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2162)..(2162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2179)..(2179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2183)..(2183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2188)..(2188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2258)..(2258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2264)..(2264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2309)..(2309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2323)..(2323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2338)..(2338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2340)..(2340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2357)..(2358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2377)..(2377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2398)..(2398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2409)..(2409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2454)..(2454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2457)..(2457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2553)..(2554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2589)..(2589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2591)..(2591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2613)..(2613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2712)..(2713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2716)..(2716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2737)..(2737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2743)..(2743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2755)..(2755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2768)..(2768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2786)..(2786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2818)..(2818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2826)..(2826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2843)..(2843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2853)..(2853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2871)..(2871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2873)..(2873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3018)..(3018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3029)..(3029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3036)..(3036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3050)..(3050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3055)..(3055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3063)..(3063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3089)..(3089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3098)..(3098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3103)..(3103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3137)..(3137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3139)..(3139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3144)..(3144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3154)..(3154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3174)..(3174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3187)..(3187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3202)..(3202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3205)..(3206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3212)..(3212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3254)..(3254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3259)..(3259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3274)..(3274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3295)..(3296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3319)..(3319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3327)..(3327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3343)..(3343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3368)..(3368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3384)..(3384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3388)..(3388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3403)..(3403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3429)..(3429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3433)..(3433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3443)..(3443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3472)..(3473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3538)..(3538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3540)..(3540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3543)..(3543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3562)..(3563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3587)..(3587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3591)..(3592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3595)..(3595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3641)..(3641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3650)..(3650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3689)..(3689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3733)..(3733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3747)..(3747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3749)..(3751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3757)..(3758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3760)..(3760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3767)..(3767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3769)..(3769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3784)..(3784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3787)..(3787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3813)..(3813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3833)..(3833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3839)..(3839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3843)..(3843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3873)..(3873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3902)..(3902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3908)..(3908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3911)..(3911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3926)..(3926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3940)..(3940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3980)..(3980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3992)..(3992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3994)..(3994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4036)..(4036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4074)..(4074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4157)..(4157)
<223> Selenocysteine

<400> 2210
Met Glu Pro Glu Asp Leu Pro Trp Pro Gly Glu Leu Glu Glu Glu Glu 
1               5                   10                  15      


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Asn Val Asp Asp Val Val Val Val Glu Glu Val Glu Glu 
        35                  40                  45              


Glu Ala Gly Arg Glu Leu Asp Ser Asp Ser His Tyr Gly Pro Gln His 
    50                  55                  60                  


Leu Glu Ser Ile Asp Asp Glu Glu Asp Glu Glu Ala Lys Ala Trp Leu 
65                  70                  75                  80  


Gln Ala His Pro Gly Arg Ile Leu Pro Pro Leu Ser Pro Pro Gln His 
                85                  90                  95      


Arg Tyr Ser Glu Gly Glu Arg Xaa Ser Leu Glu Lys Ile Val Pro Leu 
            100                 105                 110         


Xaa Cys His Val Trp Gln Gln Ile Val Tyr Gln Gly Asn Ser Arg Xaa 
        115                 120                 125             


Gln Ile Ser Asp Xaa Asn Val Val Cys Leu Glu Xaa Xaa Ala Gln Arg 
    130                 135                 140                 


Gly Ser Gly Asp Asp Gln Lys Xaa Glu Ser Trp His Cys Leu Pro Gln 
145                 150                 155                 160 


Glu Met Asp Ser Ser Gln Xaa Leu Asp Xaa Ser Gln Xaa Arg Phe Asn 
                165                 170                 175     


Val Arg Xaa Glu Asp Xaa Glu Val Xaa Asp Phe Pro Ser Leu Glu Glu 
            180                 185                 190         


Gly Ile Leu Xaa Gln Ser Glu Asn Gln Val Lys Glu Pro Asn Arg Asp 
        195                 200                 205             


Leu Phe Cys Ser Pro Leu Leu Val Ile Gln Asp Ser Phe Ala Ser Pro 
    210                 215                 220                 


Asp Leu Pro Leu Leu Xaa Cys Leu Xaa Gln Asp Gln Glu Phe Ala Pro 
225                 230                 235                 240 


Asp Ser Leu Phe His Gln Ser Glu Leu Ser Phe Ala Pro Leu Arg Gly 
                245                 250                 255     


Ile Pro Asp Lys Ser Glu Asp Xaa Glu Trp Ser Ser Arg Pro Ser Glu 
            260                 265                 270         


Val Ser Glu Ala Leu Phe Gln Ala Xaa Ala Glu Val Ala Ser Asp Leu 
        275                 280                 285             


Ala Ser Ser Arg Phe Ser Val Ser Gln His Pro Leu Ile Gly Ser Xaa 
    290                 295                 300                 


Ala Val Gly Ser Gln Cys Pro Phe Leu Pro Ser Glu Gln Gly Asn Asn 
305                 310                 315                 320 


Glu Glu Xaa Ile Ser Ser Val Asp Glu Leu Lys Ile Pro Lys Asp Cys 
                325                 330                 335     


Asp Arg Tyr Asp Asp Leu Cys Ser Tyr Met Ser Trp Lys Xaa Arg Lys 
            340                 345                 350         


Asp Xaa Gln Trp Pro Glu Asn Asn Leu Ala Asp Lys Asp Gln Val Ser 
        355                 360                 365             


Val Ala Xaa Ser Phe Asp Ile Xaa Asp Glu Asn Ile Ala Xaa Lys Arg 
    370                 375                 380                 


Ser Asp His Phe Asp Ala Ala Arg Ser Tyr Gly Gln Tyr Trp Xaa Gln 
385                 390                 395                 400 


Glu Asp Ser Ser Lys Gln Ala Glu Xaa Tyr Leu Xaa Lys Gly Leu Gln 
                405                 410                 415     


Gly Lys Val Glu Ser Asp Val Ile Xaa Leu Asp Gly Leu Asn Glu Asn 
            420                 425                 430         


Ala Val Val Cys Ser Glu Arg Val Ala Glu Leu Gln Arg Lys Pro Xaa 
        435                 440                 445             


Arg Glu Ser Glu Tyr His Ser Ser Asp Leu Arg Met Leu Arg Met Ser 
    450                 455                 460                 


Pro Asp Xaa Val Pro Lys Ala Pro Lys His Leu Lys Ala Gly Asp Xaa 
465                 470                 475                 480 


Ser Lys Gly Gly Ile Ala Lys Val Xaa Gln Ser Asn Leu Lys Ser Gly 
                485                 490                 495     


Ile Xaa Xaa Xaa Pro Val Asp Ser Asp Ile Gly Ser His Leu Ser Leu 
            500                 505                 510         


Ser Leu Glu Asp Leu Ser Gln Leu Ala Val Ser Ser Pro Leu Glu Xaa 
        515                 520                 525             


Xaa Xaa Gly Gln His Xaa Asp Xaa Leu Asn Gln Lys Xaa Leu Ala Asp 
    530                 535                 540                 


Xaa His Leu Xaa Glu Glu Xaa Leu Lys Val Xaa Ala Ile Pro Glu Pro 
545                 550                 555                 560 


Ala Asp Gln Lys Xaa Ala Xaa Pro Xaa Val Leu Ser Ser Ser His Ser 
                565                 570                 575     


His Arg Gly Lys Pro Ser Ile Phe Tyr Gln Gln Gly Leu Pro Asp Ser 
            580                 585                 590         


His Leu Xaa Glu Glu Ala Leu Lys Val Ser Ala Ala Pro Gly Leu Ala 
        595                 600                 605             


Asp Gln Xaa Xaa Gly Met Ser Xaa Leu Xaa Ser Xaa Ser Tyr Ser His 
    610                 615                 620                 


Arg Glu Lys Pro Gly Xaa Phe Tyr Gln Gln Glu Leu Pro Glu Ser Asn 
625                 630                 635                 640 


Leu Xaa Glu Glu Pro Leu Glu Val Ser Ala Ala Pro Gly Pro Val Glu 
                645                 650                 655     


Gln Lys Xaa Gly Ile Pro Xaa Val Ser Ser Xaa Ser His Ser His Val 
            660                 665                 670         


Glu Asp Leu Leu Phe Phe Tyr Arg Gln Xaa Leu Pro Asp Gly His Leu 
        675                 680                 685             


Xaa Asp Gln Ala Leu Lys Val Ser Ala Val Ser Gly Pro Ala Asp Gln 
    690                 695                 700                 


Lys Xaa Gly Xaa Ala Xaa Val Leu Ser Xaa Pro His Ser His Arg Glu 
705                 710                 715                 720 


Lys Pro Gly Ile Phe Tyr Gln Gln Glu Phe Ala Asp Ser His Gln Xaa 
                725                 730                 735     


Glu Glu Xaa Leu Xaa Lys Val Ser Ala Xaa Pro Gly Pro Ala Asp Gln 
            740                 745                 750         


Lys Xaa Glu Ile Pro Ala Val Gln Ser Ser Ser Tyr Ser Gln Arg Glu 
        755                 760                 765             


Lys Pro Ser Ile Leu Tyr Pro Gln Asp Leu Ala Asp Ser His Leu Pro 
    770                 775                 780                 


Glu Glu Gly Leu Lys Val Ser Ala Val Ala Gly Pro Ala Asp Gln Lys 
785                 790                 795                 800 


Xaa Gly Leu Pro Xaa Val Pro Ser Ser Ala Tyr Ser His Arg Glu Lys 
                805                 810                 815     


Leu Leu Val Phe Tyr Gln Gln Ala Leu Leu Asp Ser His Leu Pro Glu 
            820                 825                 830         


Glu Ala Leu Lys Val Ser Ala Val Ser Gly Pro Ala Asp Gly Lys Xaa 
        835                 840                 845             


Gly Xaa Pro Ala Val Xaa Ser Xaa Ser Ser Ala Ser Ser Ser Leu Gly 
    850                 855                 860                 


Glu Lys Pro Ser Ala Phe Tyr Gln Gln Xaa Leu Pro Asn Ser His Leu 
865                 870                 875                 880 


Xaa Glu Glu Ala Leu Lys Val Ser Ile Val Pro Gly Pro Gly Asp Gln 
                885                 890                 895     


Lys Xaa Gly Ile Pro Ser Ala Pro Ser Ser Phe Tyr Ser His Arg Glu 
            900                 905                 910         


Lys Pro Ile Ile Phe Ser Gln Gln Xaa Leu Pro Asp Phe Leu Phe Pro 
        915                 920                 925             


Glu Glu Ala Leu Lys Val Ser Ala Val Ser Val Leu Ala Ala Gln Lys 
    930                 935                 940                 


Xaa Gly Xaa Pro Xaa Val Ser Ser Asn Ser His Ser His Ser Glu Lys 
945                 950                 955                 960 


Ser Ser Val Phe Tyr Gln Gln Glu Leu Pro Asp Ser Asp Leu Pro Arg 
                965                 970                 975     


Glu Ser Leu Lys Met Ser Ala Ile Pro Gly Leu Xaa Asp Gln Lys Xaa 
            980                 985                 990         


Val Pro Xaa Pro Xaa Val Pro Ser  Gly Ser Phe Ser His  Arg Glu Lys 
        995                 1000                 1005             


Pro Ser  Ile Phe Tyr Gln Gln  Glu Trp Pro Asp Ser  Tyr Ala Xaa 
    1010                 1015                 1020             


Glu Lys  Ala Leu Lys Val Ser  Xaa Gly Pro Gly Pro  Ala Asp Gln 
    1025                 1030                 1035             


Lys Xaa  Glu Ile Pro Ala Val  Gln Ser Ser Ser Tyr  Pro Gln Arg 
    1040                 1045                 1050             


Glu Lys  Pro Ser Val Leu Tyr  Pro Gln Val Leu Ser  Asp Ser His 
    1055                 1060                 1065             


Leu Pro  Glu Glu Ser Leu Lys  Val Ser Ala Phe Pro  Gly Pro Ala 
    1070                 1075                 1080             


Asp Gln  Met Xaa Asp Xaa Pro  Ala Val Pro Ser Xaa  Phe Tyr Ser 
    1085                 1090                 1095             


Gln Arg  Glu Lys Pro Gly Ile  Phe Tyr Gln Gln Xaa  Leu Pro Glu 
    1100                 1105                 1110             


Ser His  Leu Pro Lys Glu Ala  Leu Lys Ile Ser Val  Ala Pro Gly 
    1115                 1120                 1125             


Leu Ala  Asp Gln Lys Xaa Gly  Xaa Pro Xaa Val Xaa  Ser Xaa Ser 
    1130                 1135                 1140             


Tyr Ser  Gln His Arg Glu Lys  Pro Ser Ile Phe His  Gln Gln Ala 
    1145                 1150                 1155             


Leu Pro  Gly Xaa His Ile Pro  Glu Glu Ala Gln Lys  Val Ser Ala 
    1160                 1165                 1170             


Val Xaa  Gly Pro Gly Asn Gln  Lys Xaa Trp Ile Pro  Arg Val Leu 
    1175                 1180                 1185             


Ser Xaa  Phe Tyr Ser Gln Arg  Glu Lys Pro Gly Ile  Phe Tyr Gln 
    1190                 1195                 1200             


Gln Xaa  Leu Pro Gly Ser His  Ile Pro Glu Glu Ala  Gln Lys Val 
    1205                 1210                 1215             


Ser Pro  Val Leu Gly Pro Ala  Asp Gln Lys Xaa Gly  Xaa Pro Xaa 
    1220                 1225                 1230             


Pro Xaa  Ser Ala Ser Tyr Ser  His Xaa Glu Lys Pro  Gly Ile Phe 
    1235                 1240                 1245             


Tyr Gln  Gln Val Leu Pro Asp  Asn His Pro Xaa Glu  Glu Ala Leu 
    1250                 1255                 1260             


Lys Ile  Ser Val Ala Ser Glu  Pro Val Asp Gln Xaa  Xaa Gly Xaa 
    1265                 1270                 1275             


Pro Ala  Val Xaa Ser Xaa Ser  Tyr Ser Gln Tyr Arg  Glu Lys Pro 
    1280                 1285                 1290             


Ser Ile  Phe Tyr Gln Gln Ser  Leu Pro Ser Ser His  Leu Xaa Glu 
    1295                 1300                 1305             


Glu Ala  Lys Asn Val Ser Ala  Val Pro Gly Pro Ala  Asp Gln Lys 
    1310                 1315                 1320             


Xaa Val  Ile Pro Ile Leu Pro  Ser Xaa Phe Tyr Ser  His Xaa Glu 
    1325                 1330                 1335             


Lys Pro  Gly Val Phe Tyr Gln  Gln Val Leu Pro His  Ser His Pro 
    1340                 1345                 1350             


Xaa Glu  Glu Ala Leu Lys Ile  Ser Val Ala Ser Glu  Pro Val Asp 
    1355                 1360                 1365             


Gln Xaa  Xaa Gly Xaa Pro Xaa  Val Xaa Ser Xaa Ser  Tyr Ser Gln 
    1370                 1375                 1380             


His Xaa  Glu Lys Pro Ser Ile  Phe Tyr Gln Gln Ser  Leu Pro Gly 
    1385                 1390                 1395             


Ser His  Leu Xaa Glu Glu Ala  Lys Asn Val Ser Ala  Val Pro Gly 
    1400                 1405                 1410             


Pro Gly  Asp Arg Lys Xaa Gly  Ile Pro Xaa Leu Pro  Ser Xaa Phe 
    1415                 1420                 1425             


Tyr Ser  His Xaa Glu Lys Pro  Gly Ser Phe Tyr Gln  Gln Val Leu 
    1430                 1435                 1440             


Pro His  Ser His Leu Pro Glu  Glu Ala Leu Glu Val  Ser Val Ala 
    1445                 1450                 1455             


Pro Gly  Pro Val Asp Gln Xaa  Ile Gly Xaa Pro Xaa  Val Xaa Ser 
    1460                 1465                 1470             


Pro Ser  Ser Ser Phe Gly Glu  Lys Pro Ile Val Ile  Tyr Lys Gln 
    1475                 1480                 1485             


Ala Phe  Pro Glu Gly His Leu  Pro Glu Glu Ser Leu  Lys Val Ser 
    1490                 1495                 1500             


Val Ala  Pro Gly Pro Val Gly  Gln Xaa Xaa Gly Ala  Pro Xaa Ile 
    1505                 1510                 1515             


Xaa Ser  Pro Ser Tyr Ser Gln  His Arg Ala Lys Ser  Gly Ser Phe 
    1520                 1525                 1530             


Tyr Gln  Leu Ala Leu Leu Gly  Ser Gln Ile Pro Glu  Glu Ala Leu 
    1535                 1540                 1545             


Arg Val  Ser Ser Ala Pro Gly  Pro Ala Asp Gln Xaa  Xaa Gly Ile 
    1550                 1555                 1560             


Pro Xaa  Ile Xaa Ser Xaa Ser  Tyr Ser Phe Gly Glu  Lys Pro Ile 
    1565                 1570                 1575             


Val Asn  Tyr Lys Gln Ala Phe  Pro Asp Gly His Leu  Pro Glu Glu 
    1580                 1585                 1590             


Ala Leu  Lys Val Ser Ile Val  Ser Gly Pro Xaa Glu  Lys Lys Xaa 
    1595                 1600                 1605             


Asp Ile  Pro Ala Gly Pro Leu  Gly Ser Ser Ala Leu  Gly Glu Lys 
    1610                 1615                 1620             


Pro Ile  Xaa Phe Tyr Arg Gln  Ala Leu Leu Asp Ser  Pro Leu Asn 
    1625                 1630                 1635             


Lys Glu  Val Val Lys Val Ser  Ala Ala Pro Gly Pro  Ala Asp Gln 
    1640                 1645                 1650             


Lys Xaa  Glu Xaa Leu Pro Val  His Ser Xaa Ser Tyr  Ser Asn Arg 
    1655                 1660                 1665             


Gly Lys  Pro Val Ile Phe Tyr  Gln Gln Xaa Leu Ser  Asp Ser His 
    1670                 1675                 1680             


Leu Pro  Glu Glu Ala Leu Lys  Val Pro Pro Val Pro  Gly Pro Asp 
    1685                 1690                 1695             


Ala Gln  Lys Xaa Glu Xaa Pro  Ser Val Ser Ser Ser  Leu Tyr Ser 
    1700                 1705                 1710             


Tyr Arg  Glu Lys Pro Ile Val  Phe Tyr Gln Gln Ala  Leu Pro Asp 
    1715                 1720                 1725             


Ser Glu  Leu Xaa Gln Glu Ala  Leu Lys Val Ser Ala  Val Pro Gln 
    1730                 1735                 1740             


Pro Ala  Asp Gln Lys Xaa Gly  Leu Ser Xaa Val Xaa  Ser Ser Phe 
    1745                 1750                 1755             


Tyr Ser  His Xaa Glu Lys Pro  Asn Ile Ser Tyr Gln  Gln Glu Leu 
    1760                 1765                 1770             


Pro Asp  Ser His Leu Xaa Glu  Glu Ala Leu Lys Val  Ser Asn Val 
    1775                 1780                 1785             


Pro Gly  Pro Ala Asp Gln Lys  Xaa Gly Val Ser Xaa  Val Xaa Ser 
    1790                 1795                 1800             


Xaa Ser  Tyr Ser His Arg Glu  Lys Pro Ile Val Ser  Tyr Gln Arg 
    1805                 1810                 1815             


Glu Leu  Pro His Phe Xaa Glu  Ala Gly Leu Lys Ile  Leu Arg Val 
    1820                 1825                 1830             


Pro Gly  Pro Ala Asp Gln Lys  Xaa Gly Ile Asn Ile  Leu Pro Ser 
    1835                 1840                 1845             


Asn Ser  Tyr Pro Gln Arg Glu  His Ser Val Ile Ser  Tyr Glu Gln 
    1850                 1855                 1860             


Glu Leu  Pro Asp Leu Xaa Glu  Val Xaa Leu Lys Ala  Ile Gly Val 
    1865                 1870                 1875             


Pro Gly  Pro Ala Asp Gln Lys  Xaa Gly Ile Gln Ile  Ala Ser Ser 
    1880                 1885                 1890             


Ser Ser  Tyr Ser Asn Arg Glu  Lys Ala Ser Ile Phe  His Gln Gln 
    1895                 1900                 1905             


Glu Leu  Pro Asp Val Xaa Glu  Glu Ala Leu Asn Val  Phe Val Val 
    1910                 1915                 1920             


Pro Gly  Gln Gly Asp Arg Lys  Xaa Glu Ile Pro Xaa  Val Pro Leu 
    1925                 1930                 1935             


Ser Tyr  Tyr Ser Arg Arg Glu  Lys Pro Ser Val Ile  Ser Gln Gln 
    1940                 1945                 1950             


Glu Leu  Pro Asp Ser His Leu  Xaa Glu Glu Ala Leu  Lys Val Ser 
    1955                 1960                 1965             


Pro Val  Ser Ile Pro Ala Glu  Gln Lys Xaa Gly Ile  Pro Ile Gly 
    1970                 1975                 1980             


Leu Ser  Ser Ser Tyr Ser His  Ser His Lys Glu Lys  Leu Lys Ile 
    1985                 1990                 1995             


Ser Xaa  Val His Ile Pro Asp  Asp Gln Lys Xaa Glu  Phe Pro Ala 
    2000                 2005                 2010             


Ala Xaa  Leu Ser Ser Tyr Ser  Gln Ile Glu Lys Pro  Lys Ile Ser 
    2015                 2020                 2025             


Xaa Val  Ile Gly Pro Asn Asp  Gln Lys Xaa Pro Ser  Gln Xaa Ala 
    2030                 2035                 2040             


Phe His  Ser Ser Tyr Ser Gln  Xaa Val Lys Pro Asn  Ile Leu Phe 
    2045                 2050                 2055             


Gln Gln  Gln Leu Pro Asp Arg  Asp Gln Ser Lys Gly  Ile Leu Lys 
    2060                 2065                 2070             


Ile Ser  Ala Val Pro Glu Leu  Xaa Asp Val Asn Xaa  Gly Lys Pro 
    2075                 2080                 2085             


Val Ser  Leu Ser Ser Ser Tyr  Phe His Arg Glu Lys  Ser Asn Ile 
    2090                 2095                 2100             


Phe Ser  Pro Gln Glu Leu Pro  Gly Ser His Val Xaa  Glu Asp Val 
    2105                 2110                 2115             


Leu Lys  Val Ser Xaa Ile Pro  Gly Pro Ala Gly Gln  Lys Xaa Val 
    2120                 2125                 2130             


Leu Pro  Xaa Ala Leu Pro Ser  Ser Phe Ser His Arg  Glu Lys Pro 
    2135                 2140                 2145             


Asp Ile  Phe Tyr Gln Lys Asp  Leu Pro Asp Arg His  Leu Xaa Glu 
    2150                 2155                 2160             


Asp Ala  Leu Lys Ile Ser Ser  Ala Leu Gly Gln Ala  Asp Gln Ile 
    2165                 2170                 2175             


Xaa Gly  Leu Gln Xaa Val Pro  Ser Gly Xaa Tyr Ser  His Gly Glu 
    2180                 2185                 2190             


Asn His  Lys Leu Val Ser Glu  His Val Gln Arg Leu  Ile Asp Asn 
    2195                 2200                 2205             


Leu Asn  Ser Ser Asp Ser Ser  Val Ser Ser Asn Asn  Val Leu Leu 
    2210                 2215                 2220             


Asn Ser  Gln Ala Asp Asp Arg  Val Val Ile Asn Lys  Pro Glu Ser 
    2225                 2230                 2235             


Ala Gly  Phe Arg Asp Val Gly  Ser Glu Glu Ile Gln  Asp Ala Glu 
    2240                 2245                 2250             


Asn Ser  Ala Lys Xaa Leu Lys  Glu Ile Arg Xaa Leu  Leu Met Glu 
    2255                 2260                 2265             


Ala Glu  Asn Met Ala Leu Lys  Arg Cys Asn Phe Pro  Ala Pro Leu 
    2270                 2275                 2280             


Ala Arg  Phe Arg Asp Ile Ser  Asp Ile Ser Phe Ile  Gln Ser Lys 
    2285                 2290                 2295             


Lys Val  Val Cys Phe Lys Glu  Pro Ser Ser Xaa Gly  Val Ser Asn 
    2300                 2305                 2310             


Gly Asp  Leu Leu His Arg Gln  Pro Phe Xaa Glu Glu  Ser Pro Ser 
    2315                 2320                 2325             


Ser Arg  Cys Ile Gln Lys Asp  Ile Gly Xaa Gln Xaa  Asn Leu Lys 
    2330                 2335                 2340             


Cys Arg  Arg Gly Ile Glu Asn  Trp Glu Phe Ile Ser  Ser Xaa Xaa 
    2345                 2350                 2355             


Val Arg  Ser Pro Leu Gln Glu  Ala Glu Ser Lys Val  Ser Met Ala 
    2360                 2365                 2370             


Leu Glu  Glu Xaa Leu Arg Gln  Tyr Gln Ala Ala Lys  Ser Val Met 
    2375                 2380                 2385             


Arg Ser  Glu Pro Glu Gly Cys  Ser Gly Xaa Ile Gly  Asn Lys Ile 
    2390                 2395                 2400             


Ile Ile  Pro Met Met Xaa Val  Ile Lys Ser Asp Ser  Ser Ser Asp 
    2405                 2410                 2415             


Ala Ser  Asp Gly Asn Gly Ser  Cys Ser Trp Asp Ser  Asn Leu Pro 
    2420                 2425                 2430             


Glu Ser  Leu Glu Ser Val Ser  Asp Val Leu Leu Asn  Phe Phe Pro 
    2435                 2440                 2445             


Tyr Val  Ser Pro Lys Xaa Ser  Ile Xaa Asp Ser Arg  Glu Glu Glu 
    2450                 2455                 2460             


Gly Val  Ser Glu Ser Glu Asp  Gly Gly Gly Ser Ser  Val Asp Ser 
    2465                 2470                 2475             


Leu Ala  Ala His Val Lys Asn  Leu Leu Gln Cys Glu  Ser Ser Leu 
    2480                 2485                 2490             


Asn His  Ala Lys Glu Ile Leu  Arg Asn Ala Glu Glu  Glu Glu Ser 
    2495                 2500                 2505             


Arg Val  Arg Ala His Ala Trp  Asn Met Lys Phe Asn  Leu Ala His 
    2510                 2515                 2520             


Asp Cys  Gly Tyr Ser Ile Ser  Glu Leu Asn Glu Asp  Asp Arg Arg 
    2525                 2530                 2535             


Lys Val  Glu Glu Ile Lys Ala  Glu Leu Phe Gly His  Gly Arg Xaa 
    2540                 2545                 2550             


Xaa Asp  Leu Ser Lys Gly Leu  Gln Ser Pro Arg Gly  Met Gly Cys 
    2555                 2560                 2565             


Lys Pro  Glu Ala Val Cys Ser  His Ile Ile Ile Glu  Ser His Glu 
    2570                 2575                 2580             


Lys Gly  Cys Phe Arg Xaa Leu  Xaa Ser Glu His Pro  Gln Leu Asp 
    2585                 2590                 2595             


Arg His  Pro Cys Ala Phe Arg  Ser Ala Gly Pro Ser  Glu Met Xaa 
    2600                 2605                 2610             


Arg Gly  Arg Gln Asn Pro Ser  Ser Cys Arg Ala Lys  His Val Asn 
    2615                 2620                 2625             


Leu Ser  Ala Ser Leu Asp Gln  Asn Asn Ser His Phe  Lys Val Trp 
    2630                 2635                 2640             


Asn Ser  Leu Gln Leu Lys Ser  His Ser Pro Phe Gln  Asn Phe Ile 
    2645                 2650                 2655             


Pro Asp  Glu Phe Lys Ile Ser  Lys Gly Leu Arg Met  Pro Phe Asp 
    2660                 2665                 2670             


Glu Lys  Met Asp Pro Trp Leu  Ser Glu Leu Val Glu  Pro Ala Phe 
    2675                 2680                 2685             


Val Pro  Pro Lys Glu Val Asp  Phe His Ser Ser Ser  Gln Met Pro 
    2690                 2695                 2700             


Ser Pro  Glu Pro Met Lys Lys  Phe Xaa Xaa Ser Ile  Xaa Phe Ser 
    2705                 2710                 2715             


Ser His  Arg His Ser Lys Cys  Ile Ser Asn Ser Ser  Val Val Lys 
    2720                 2725                 2730             


Val Gly  Val Xaa Glu Gly Ser  Gln Cys Xaa Gly Ala  Ser Val Gly 
    2735                 2740                 2745             


Val Phe  Asn Ser His Phe Xaa  Glu Glu Gln Asn Pro  Pro Arg Asp 
    2750                 2755                 2760             


Leu Lys  Gln Lys Xaa Ser Ser  Pro Ser Ser Phe Lys  Met His Ser 
    2765                 2770                 2775             


Asn Ser  Gln Asp Lys Glu Val  Xaa Ile Leu Ala Glu  Gly Arg Arg 
    2780                 2785                 2790             


Gln Ser  Gln Lys Leu Pro Val  Asp Phe Glu Arg Ser  Phe Gln Glu 
    2795                 2800                 2805             


Glu Lys  Pro Leu Glu Arg Ser  Asp Phe Xaa Gly Ser  His Ser Glu 
    2810                 2815                 2820             


Pro Ser  Xaa Arg Ala Asn Cys  Ser Asn Phe Lys Glu  Ile Gln Ile 
    2825                 2830                 2835             


Ser Asp  Asn His Xaa Leu Ile  Ser Met Gly Arg Pro  Ser Ser Xaa 
    2840                 2845                 2850             


Leu Gly  Val Asn Arg Ser Ser  Ser Arg Leu Gly Val  Lys Glu Lys 
    2855                 2860                 2865             


Asn Val  Xaa Ile Xaa Pro Asp  Leu Pro Ser Cys Ile  Phe Leu Glu 
    2870                 2875                 2880             


Gln Arg  Glu Leu Phe Glu Gln  Ser Lys Ala Pro Arg  Ala Asp Asp 
    2885                 2890                 2895             


His Val  Arg Lys His His Ser  Pro Ser Pro Gln His  Gln Asp Tyr 
    2900                 2905                 2910             


Val Ala  Pro Asp Leu Pro Ser  Cys Ile Phe Leu Glu  Gln Arg Glu 
    2915                 2920                 2925             


Leu Phe  Glu Gln Cys Lys Ala  Pro Tyr Val Asp His  Gln Met Arg 
    2930                 2935                 2940             


Glu Asn  His Ser Pro Leu Pro  Gln Gly Gln Asp Ser  Ile Ala Ser 
    2945                 2950                 2955             


Asp Leu  Pro Ser Pro Ile Ser  Leu Glu Gln Cys Gln  Ser Lys Ala 
    2960                 2965                 2970             


Pro Gly  Val Asp Asp Gln Met  Asn Lys His His Phe  Pro Leu Pro 
    2975                 2980                 2985             


Gln Gly  Gln Asp Cys Val Val  Glu Lys Asn Asn Gln  His Lys Pro 
    2990                 2995                 3000             


Lys Ser  His Ile Ser Asn Ile  Asn Val Glu Ala Lys  Phe Asn Xaa 
    3005                 3010                 3015             


Val Val  Ser Gln Ser Ala Pro  Asn His Cys Xaa Leu  Ala Ala Ser 
    3020                 3025                 3030             


Ala Ser  Xaa Pro Pro Ser Asn  Arg Lys Ala Leu Ser  Cys Val His 
    3035                 3040                 3045             


Ile Xaa  Leu Cys Pro Lys Xaa  Ser Ser Lys Leu Asp  Ser Gly Xaa 
    3050                 3055                 3060             


Leu Asp  Glu Arg Phe His Ser  Leu Asp Ala Ala Ser  Lys Ala Arg 
    3065                 3070                 3075             


Met Asn  Ser Glu Phe Asn Phe  Asp Leu His Xaa Val  Ser Ser Arg 
    3080                 3085                 3090             


Ser Leu  Glu Pro Xaa Ser Lys  Leu Leu Xaa Ser Lys  Pro Val Ala 
    3095                 3100                 3105             


Gln Asp  Gln Glu Ser Leu Gly  Phe Leu Gly Pro Lys  Ser Ser Leu 
    3110                 3115                 3120             


Asp Phe  Gln Val Val Gln Pro  Ser Leu Pro Asp Ser  Asn Xaa Ile 
    3125                 3130                 3135             


Xaa Gln  Asp Leu Lys Xaa Ile  Pro Ser Gln Asn Ser  Gln Ile Val 
    3140                 3145                 3150             


Xaa Ser  Arg Gln Ile Gln Val  Asn Ile Ser Asp Phe  Glu Gly His 
    3155                 3160                 3165             


Ser Asn  Pro Glu Gly Xaa Pro  Val Phe Ala Asp Arg  Leu Pro Glu 
    3170                 3175                 3180             


Lys Met  Lys Xaa Pro Leu Ser  Ala Phe Ser Glu Lys  Leu Ser Ser 
    3185                 3190                 3195             


Asp Ala  Val Xaa Gln Ile Xaa  Xaa Glu Ser Pro Glu  Lys Xaa Leu 
    3200                 3205                 3210             


Phe Ser  Ser Glu Ile Phe Ile  Asn Ala Glu Asp Arg  Gly His Glu 
    3215                 3220                 3225             


Ile Ile  Glu Pro Gly Asn Gln  Lys Leu Arg Lys Ala  Pro Val Lys 
    3230                 3235                 3240             


Phe Ala  Ser Ser Ser Ser Val  Gln Gln Val Xaa Phe  Ser Arg Gly 
    3245                 3250                 3255             


Xaa Asp  Gly Gln Pro Leu Leu  Leu Pro Tyr Lys Pro  Ser Gly Ser 
    3260                 3265                 3270             


Xaa Lys  Met Tyr Tyr Val Pro  Gln Leu Arg Gln Ile  Pro Pro Ser 
    3275                 3280                 3285             


Pro Asp  Ser Lys Ser Asp Xaa  Xaa Val Glu Ser Ser  His Ser Gly 
    3290                 3295                 3300             


Ser Asn  Asp Ala Ile Ala Pro  Asp Phe Pro Ala Gln  Val Leu Gly 
    3305                 3310                 3315             


Xaa Arg  Asp Asp Asp Leu Ser  Ala Xaa Val Asn Ile  Lys His Lys 
    3320                 3325                 3330             


Glu Gly  Ile Tyr Ser Lys Arg  Val Val Xaa Lys Ala  Ser Leu Pro 
    3335                 3340                 3345             


Val Gly  Glu Lys Pro Leu Gln  Asn Glu Asn Ala Asp  Ala Ser Val 
    3350                 3355                 3360             


Gln Val  Leu Ile Xaa Gly Asp  Glu Asn Leu Ser Asp  Lys Lys Gln 
    3365                 3370                 3375             


Gln Glu  Ile His Ser Xaa Arg  Ala Val Xaa Glu Ala  Ala Gln Ala 
    3380                 3385                 3390             


Lys Glu  Lys Glu Ser Leu Gln  Lys Asp Xaa Ala Asp  Ser Ser Ala 
    3395                 3400                 3405             


Ala Ala  Ala Ala Glu His Ser  Ala Gln Val Gly Asp  Pro Glu Met 
    3410                 3415                 3420             


Lys Asn  Leu Pro Asp Xaa Lys  Ala Ile Xaa Gln Lys  Glu Glu Ile 
    3425                 3430                 3435             


His Arg  Lys Lys Xaa Val Pro  Glu Glu Ala Trp Pro  Asn Asn Lys 
    3440                 3445                 3450             


Glu Ser  Leu Gln Ile Asn Ile  Glu Glu Ser Glu Cys  His Ser Glu 
    3455                 3460                 3465             


Phe Glu  Asn Xaa Xaa Arg Ser  Val Phe Arg Ser Ala  Lys Phe Tyr 
    3470                 3475                 3480             


Ile His  His Pro Val His Leu  Pro Ser Asp Gln Asp  Ile Cys His 
    3485                 3490                 3495             


Glu Ser  Leu Gly Lys Ser Val  Phe Met Arg His Ser  Trp Lys Asp 
    3500                 3505                 3510             


Phe Phe  Gln His His Pro Asp  Lys His Arg Glu His  Met Cys Leu 
    3515                 3520                 3525             


Pro Leu  Pro Tyr Gln Asn Met  Asp Lys Xaa Lys Xaa  Asp Tyr Xaa 
    3530                 3535                 3540             


Arg Ile  Lys Ser Leu Ser Ile  Asn Val Asn Leu Gly  Asn Lys Glu 
    3545                 3550                 3555             


Val Met  Asp Xaa Xaa Lys Ser  Gln Val Arg Asp Tyr  Pro Lys His 
    3560                 3565                 3570             


Asn Gly  Gln Ile Ser Asp Pro  Gln Arg Asp Gln Lys  Val Xaa Pro 
    3575                 3580                 3585             


Glu Gln  Xaa Xaa Gln His Xaa  Val Ser Leu Asn Glu  Leu Trp Asn 
    3590                 3595                 3600             


Lys Tyr  Arg Glu Arg Gln Arg  Gln Gln Arg Gln Pro  Glu Leu Gly 
    3605                 3610                 3615             


Asp Arg  Lys Glu Leu Ser Leu  Val Asp Arg Leu Asp  Arg Leu Ala 
    3620                 3625                 3630             


Lys Ile  Leu Gln Asn Pro Ile  Xaa His Ser Leu Gln  Val Ser Glu 
    3635                 3640                 3645             


Ser Xaa  His Asp Asp Ser Arg  Gly Glu Arg Ser Val  Lys Glu Trp 
    3650                 3655                 3660             


Ser Gly  Arg Gln Gln Gln Arg  Asn Lys Leu Gln Lys  Lys Lys Arg 
    3665                 3670                 3675             


Phe Lys  Ser Leu Glu Lys Ser  His Lys Asn Xaa Gly  Glu Leu Lys 
    3680                 3685                 3690             


Lys Ser  Lys Val Leu Ser His  His Arg Ala Gly Arg  Ser Asn Gln 
    3695                 3700                 3705             


Ile Lys  Ile Glu Gln Ile Lys  Phe Asp Lys Tyr Ile  Leu Ser Lys 
    3710                 3715                 3720             


Gln Pro  Gly Phe Asn Tyr Ile  Ser Asn Xaa Ser Ser  Asp Cys Arg 
    3725                 3730                 3735             


Pro Ser  Glu Glu Ser Glu Leu  Leu Xaa Asp Xaa Xaa  Xaa Asn Ile 
    3740                 3745                 3750             


Leu Ser  Gly Xaa Xaa Ser Xaa  Val Glu Ser Asp Ile  Leu Xaa Gln 
    3755                 3760                 3765             


Xaa Asp  Arg Glu Val Ala Leu  His Glu Arg Ser Ser  Ser Val Ser 
    3770                 3775                 3780             


Xaa Ile  Asp Xaa Ala Arg Leu  Ile Gln Ala Phe Gly  His Glu Arg 
    3785                 3790                 3795             


Val Cys  Leu Ser Pro Arg Arg  Ile Lys Leu Tyr Ser  Ser Ile Xaa 
    3800                 3805                 3810             


Asn Gln  Gln Arg Arg Tyr Leu  Glu Lys Arg Ser Lys  His Ser Lys 
    3815                 3820                 3825             


Lys Val  Leu Asn Xaa Gly His  Pro Leu Val Xaa Ser  Glu His Xaa 
    3830                 3835                 3840             


Arg Arg  Arg His Ile Gln Val  Ala Asn His Val Ile  Ser Ser Asp 
    3845                 3850                 3855             


Ser Ile  Ser Ser Ser Ala Ser  Ser Phe Leu Ser Ser  Asn Ser Xaa 
    3860                 3865                 3870             


Phe Cys  Asn Lys Gln Asn Val  His Met Leu Asn Lys  Gly Ile Gln 
    3875                 3880                 3885             


Ala Gly  Asn Leu Glu Ile Val  Asn Gly Ala Lys Lys  His Xaa Arg 
    3890                 3895                 3900             


Asp Val  Gly Ile Xaa Phe Pro  Xaa Pro Ser Ser Ser  Glu Ala Lys 
    3905                 3910                 3915             


Leu Glu  Glu Asn Ser Asp Val  Xaa Ser Trp Ser Glu  Glu Lys Arg 
    3920                 3925                 3930             


Glu Glu  Lys Met Leu Phe Xaa  Gly Tyr Pro Glu Asp  Arg Lys Leu 
    3935                 3940                 3945             


Lys Lys  Asn Lys Lys Asn Ser  His Glu Gly Val Ser  Trp Phe Val 
    3950                 3955                 3960             


Pro Val  Glu Asn Val Glu Ser  Arg Ser Lys Lys Glu  Asn Val Pro 
    3965                 3970                 3975             


Asn Xaa  Cys Gly Pro Gly Ile  Ser Trp Phe Glu Pro  Ile Xaa Lys 
    3980                 3985                 3990             


Xaa Arg  Pro Trp Arg Glu Pro  Leu Arg Glu Gln Asn  Cys Gln Gly 
    3995                 4000                 4005             


Gln His  Leu Asp Gly Arg Gly  Tyr Leu Ala Gly Pro  Gly Arg Glu 
    4010                 4015                 4020             


Ala Gly  Arg Asp Leu Leu Arg  Pro Phe Val Arg Ala  Xaa Leu Gln 
    4025                 4030                 4035             


Glu Ser  Leu Gln Phe His Arg  Pro Asp Phe Ile Ser  Arg Ser Gly 
    4040                 4045                 4050             


Glu Arg  Ile Lys Arg Leu Lys  Leu Ile Val Gln Glu  Arg Lys Leu 
    4055                 4060                 4065             


Gln Ser  Met Leu Gln Xaa Glu  Arg Asp Ala Leu Phe  Asn Ile Asp 
    4070                 4075                 4080             


Arg Glu  Arg Gln Gly His Gln  Asn Arg Met Cys Pro  Leu Pro Lys 
    4085                 4090                 4095             


Arg Val  Phe Leu Ala Ile Gln  Lys Asn Lys Pro Ile  Ser Lys Lys 
    4100                 4105                 4110             


Glu Met  Ile Gln Arg Ser Lys  Arg Ile Tyr Glu Gln  Leu Pro Glu 
    4115                 4120                 4125             


Val Gln  Lys Lys Arg Glu Glu  Glu Lys Arg Lys Ser  Glu Tyr Lys 
    4130                 4135                 4140             


Ser Tyr  Arg Leu Arg Ala Gln  Leu Tyr Lys Lys Arg  Val Xaa Asn 
    4145                 4150                 4155             


Gln Leu  Leu Gly Arg Lys Val  Pro Trp Asp 
    4160                 4165             


<210> 2211
<211> 4126
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1120)..(1120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1187)..(1187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1189)..(1189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1191)..(1191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1193)..(1193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1200)..(1200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1240)..(1240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1282)..(1282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1328)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1343)..(1343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1360)..(1360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1377)..(1377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1426)..(1426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1428)..(1428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1430)..(1430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1470)..(1471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1475)..(1475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1477)..(1477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1518)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1523)..(1523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1525)..(1525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1527)..(1527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1562)..(1562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1566)..(1566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1584)..(1584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1613)..(1613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1615)..(1615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1636)..(1636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1660)..(1660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1662)..(1662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1690)..(1690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1707)..(1707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1711)..(1711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1713)..(1713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1720)..(1720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1737)..(1737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1758)..(1758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1762)..(1762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1782)..(1782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1799)..(1799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1827)..(1827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1830)..(1830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1844)..(1844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1872)..(1872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1889)..(1889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1893)..(1893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1919)..(1919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1936)..(1936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1958)..(1958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1967)..(1967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1973)..(1973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1987)..(1987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1996)..(1996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2000)..(2000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2009)..(2009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2039)..(2039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2043)..(2043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2073)..(2073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2081)..(2081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2090)..(2090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2094)..(2094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2120)..(2120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2137)..(2137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2141)..(2141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2146)..(2146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2216)..(2216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2222)..(2222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2267)..(2267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2281)..(2281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2296)..(2296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2298)..(2298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2315)..(2316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2335)..(2335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2356)..(2356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2367)..(2367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2412)..(2412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2415)..(2415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2511)..(2512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2547)..(2547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2549)..(2549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2571)..(2571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2670)..(2671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2674)..(2674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2695)..(2695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2701)..(2701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2713)..(2713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2726)..(2726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2744)..(2744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2776)..(2776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2784)..(2784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2801)..(2801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2811)..(2811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2829)..(2829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2831)..(2831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2976)..(2976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2987)..(2987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2994)..(2994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3008)..(3008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3013)..(3013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3021)..(3021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3047)..(3047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3056)..(3056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3061)..(3061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3095)..(3095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3097)..(3097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3102)..(3102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3112)..(3112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3132)..(3132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3145)..(3145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3160)..(3160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3163)..(3164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3170)..(3170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3212)..(3212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3217)..(3217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3232)..(3232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3253)..(3254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3277)..(3277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3285)..(3285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3301)..(3301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3326)..(3326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3342)..(3342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3346)..(3346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3361)..(3361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3387)..(3387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3391)..(3391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3401)..(3401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3430)..(3431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3496)..(3496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3498)..(3498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3501)..(3501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3520)..(3521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3545)..(3545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3549)..(3550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3553)..(3553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3599)..(3599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3608)..(3608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3647)..(3647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3691)..(3691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3705)..(3705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3707)..(3709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3715)..(3716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3718)..(3718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3725)..(3725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3727)..(3727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3742)..(3742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3745)..(3745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3771)..(3771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3791)..(3791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3797)..(3797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3801)..(3801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3831)..(3831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3860)..(3860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3866)..(3866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3869)..(3869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3884)..(3884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3898)..(3898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3938)..(3938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3950)..(3950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3952)..(3952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3994)..(3994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4032)..(4032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4115)..(4115)
<223> Selenocysteine

<400> 2211
Met Glu Pro Glu Asp Leu Pro Trp Pro Gly Glu Leu Glu Glu Glu Glu 
1               5                   10                  15      


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Asn Val Asp Asp Val Val Val Val Glu Glu Val Glu Glu 
        35                  40                  45              


Glu Ala Gly Arg Glu Leu Asp Ser Asp Ser His Tyr Gly Pro Gln His 
    50                  55                  60                  


Leu Glu Ser Ile Asp Asp Glu Glu Asp Glu Glu Ala Lys Ala Trp Leu 
65                  70                  75                  80  


Gln Ala His Pro Gly Arg Ile Leu Pro Pro Leu Ser Pro Pro Gln His 
                85                  90                  95      


Arg Tyr Ser Glu Gly Glu Arg Xaa Ser Leu Glu Lys Lys Xaa Glu Ser 
            100                 105                 110         


Trp His Cys Leu Pro Gln Glu Met Asp Ser Ser Gln Xaa Leu Asp Xaa 
        115                 120                 125             


Ser Gln Xaa Arg Phe Asn Val Arg Xaa Glu Asp Xaa Glu Val Xaa Asp 
    130                 135                 140                 


Phe Pro Ser Leu Glu Glu Gly Ile Leu Xaa Gln Ser Glu Asn Gln Val 
145                 150                 155                 160 


Lys Glu Pro Asn Arg Asp Leu Phe Cys Ser Pro Leu Leu Val Ile Gln 
                165                 170                 175     


Asp Ser Phe Ala Ser Pro Asp Leu Pro Leu Leu Xaa Cys Leu Xaa Gln 
            180                 185                 190         


Asp Gln Glu Phe Ala Pro Asp Ser Leu Phe His Gln Ser Glu Leu Ser 
        195                 200                 205             


Phe Ala Pro Leu Arg Gly Ile Pro Asp Lys Ser Glu Asp Xaa Glu Trp 
    210                 215                 220                 


Ser Ser Arg Pro Ser Glu Val Ser Glu Ala Leu Phe Gln Ala Xaa Ala 
225                 230                 235                 240 


Glu Val Ala Ser Asp Leu Ala Ser Ser Arg Phe Ser Val Ser Gln His 
                245                 250                 255     


Pro Leu Ile Gly Ser Xaa Ala Val Gly Ser Gln Cys Pro Phe Leu Pro 
            260                 265                 270         


Ser Glu Gln Gly Asn Asn Glu Glu Xaa Ile Ser Ser Val Asp Glu Leu 
        275                 280                 285             


Lys Ile Pro Lys Asp Cys Asp Arg Tyr Asp Asp Leu Cys Ser Tyr Met 
    290                 295                 300                 


Ser Trp Lys Xaa Arg Lys Asp Xaa Gln Trp Pro Glu Asn Asn Leu Ala 
305                 310                 315                 320 


Asp Lys Asp Gln Val Ser Val Ala Xaa Ser Phe Asp Ile Xaa Asp Glu 
                325                 330                 335     


Asn Ile Ala Xaa Lys Arg Ser Asp His Phe Asp Ala Ala Arg Ser Tyr 
            340                 345                 350         


Gly Gln Tyr Trp Xaa Gln Glu Asp Ser Ser Lys Gln Ala Glu Xaa Tyr 
        355                 360                 365             


Leu Xaa Lys Gly Leu Gln Gly Lys Val Glu Ser Asp Val Ile Xaa Leu 
    370                 375                 380                 


Asp Gly Leu Asn Glu Asn Ala Val Val Cys Ser Glu Arg Val Ala Glu 
385                 390                 395                 400 


Leu Gln Arg Lys Pro Xaa Arg Glu Ser Glu Tyr His Ser Ser Asp Leu 
                405                 410                 415     


Arg Met Leu Arg Met Ser Pro Asp Xaa Val Pro Lys Ala Pro Lys His 
            420                 425                 430         


Leu Lys Ala Gly Asp Xaa Ser Lys Gly Gly Ile Ala Lys Val Xaa Gln 
        435                 440                 445             


Ser Asn Leu Lys Ser Gly Ile Xaa Xaa Xaa Pro Val Asp Ser Asp Ile 
    450                 455                 460                 


Gly Ser His Leu Ser Leu Ser Leu Glu Asp Leu Ser Gln Leu Ala Val 
465                 470                 475                 480 


Ser Ser Pro Leu Glu Xaa Xaa Xaa Gly Gln His Xaa Asp Xaa Leu Asn 
                485                 490                 495     


Gln Lys Xaa Leu Ala Asp Xaa His Leu Xaa Glu Glu Xaa Leu Lys Val 
            500                 505                 510         


Xaa Ala Ile Pro Glu Pro Ala Asp Gln Lys Xaa Ala Xaa Pro Xaa Val 
        515                 520                 525             


Leu Ser Ser Ser His Ser His Arg Gly Lys Pro Ser Ile Phe Tyr Gln 
    530                 535                 540                 


Gln Gly Leu Pro Asp Ser His Leu Xaa Glu Glu Ala Leu Lys Val Ser 
545                 550                 555                 560 


Ala Ala Pro Gly Leu Ala Asp Gln Xaa Xaa Gly Met Ser Xaa Leu Xaa 
                565                 570                 575     


Ser Xaa Ser Tyr Ser His Arg Glu Lys Pro Gly Xaa Phe Tyr Gln Gln 
            580                 585                 590         


Glu Leu Pro Glu Ser Asn Leu Xaa Glu Glu Pro Leu Glu Val Ser Ala 
        595                 600                 605             


Ala Pro Gly Pro Val Glu Gln Lys Xaa Gly Ile Pro Xaa Val Ser Ser 
    610                 615                 620                 


Xaa Ser His Ser His Val Glu Asp Leu Leu Phe Phe Tyr Arg Gln Xaa 
625                 630                 635                 640 


Leu Pro Asp Gly His Leu Xaa Asp Gln Ala Leu Lys Val Ser Ala Val 
                645                 650                 655     


Ser Gly Pro Ala Asp Gln Lys Xaa Gly Xaa Ala Xaa Val Leu Ser Xaa 
            660                 665                 670         


Pro His Ser His Arg Glu Lys Pro Gly Ile Phe Tyr Gln Gln Glu Phe 
        675                 680                 685             


Ala Asp Ser His Gln Xaa Glu Glu Xaa Leu Xaa Lys Val Ser Ala Xaa 
    690                 695                 700                 


Pro Gly Pro Ala Asp Gln Lys Xaa Glu Ile Pro Ala Val Gln Ser Ser 
705                 710                 715                 720 


Ser Tyr Ser Gln Arg Glu Lys Pro Ser Ile Leu Tyr Pro Gln Asp Leu 
                725                 730                 735     


Ala Asp Ser His Leu Pro Glu Glu Gly Leu Lys Val Ser Ala Val Ala 
            740                 745                 750         


Gly Pro Ala Asp Gln Lys Xaa Gly Leu Pro Xaa Val Pro Ser Ser Ala 
        755                 760                 765             


Tyr Ser His Arg Glu Lys Leu Leu Val Phe Tyr Gln Gln Ala Leu Leu 
    770                 775                 780                 


Asp Ser His Leu Pro Glu Glu Ala Leu Lys Val Ser Ala Val Ser Gly 
785                 790                 795                 800 


Pro Ala Asp Gly Lys Xaa Gly Xaa Pro Ala Val Xaa Ser Xaa Ser Ser 
                805                 810                 815     


Ala Ser Ser Ser Leu Gly Glu Lys Pro Ser Ala Phe Tyr Gln Gln Xaa 
            820                 825                 830         


Leu Pro Asn Ser His Leu Xaa Glu Glu Ala Leu Lys Val Ser Ile Val 
        835                 840                 845             


Pro Gly Pro Gly Asp Gln Lys Xaa Gly Ile Pro Ser Ala Pro Ser Ser 
    850                 855                 860                 


Phe Tyr Ser His Arg Glu Lys Pro Ile Ile Phe Ser Gln Gln Xaa Leu 
865                 870                 875                 880 


Pro Asp Phe Leu Phe Pro Glu Glu Ala Leu Lys Val Ser Ala Val Ser 
                885                 890                 895     


Val Leu Ala Ala Gln Lys Xaa Gly Xaa Pro Xaa Val Ser Ser Asn Ser 
            900                 905                 910         


His Ser His Ser Glu Lys Ser Ser Val Phe Tyr Gln Gln Glu Leu Pro 
        915                 920                 925             


Asp Ser Asp Leu Pro Arg Glu Ser Leu Lys Met Ser Ala Ile Pro Gly 
    930                 935                 940                 


Leu Xaa Asp Gln Lys Xaa Val Pro Xaa Pro Xaa Val Pro Ser Gly Ser 
945                 950                 955                 960 


Phe Ser His Arg Glu Lys Pro Ser Ile Phe Tyr Gln Gln Glu Trp Pro 
                965                 970                 975     


Asp Ser Tyr Ala Xaa Glu Lys Ala Leu Lys Val Ser Xaa Gly Pro Gly 
            980                 985                 990         


Pro Ala Asp Gln Lys Xaa Glu Ile  Pro Ala Val Gln Ser  Ser Ser Tyr 
        995                 1000                 1005             


Pro Gln  Arg Glu Lys Pro Ser  Val Leu Tyr Pro Gln  Val Leu Ser 
    1010                 1015                 1020             


Asp Ser  His Leu Pro Glu Glu  Ser Leu Lys Val Ser  Ala Phe Pro 
    1025                 1030                 1035             


Gly Pro  Ala Asp Gln Met Xaa  Asp Xaa Pro Ala Val  Pro Ser Xaa 
    1040                 1045                 1050             


Phe Tyr  Ser Gln Arg Glu Lys  Pro Gly Ile Phe Tyr  Gln Gln Xaa 
    1055                 1060                 1065             


Leu Pro  Glu Ser His Leu Pro  Lys Glu Ala Leu Lys  Ile Ser Val 
    1070                 1075                 1080             


Ala Pro  Gly Leu Ala Asp Gln  Lys Xaa Gly Xaa Pro  Xaa Val Xaa 
    1085                 1090                 1095             


Ser Xaa  Ser Tyr Ser Gln His  Arg Glu Lys Pro Ser  Ile Phe His 
    1100                 1105                 1110             


Gln Gln  Ala Leu Pro Gly Xaa  His Ile Pro Glu Glu  Ala Gln Lys 
    1115                 1120                 1125             


Val Ser  Ala Val Xaa Gly Pro  Gly Asn Gln Lys Xaa  Trp Ile Pro 
    1130                 1135                 1140             


Arg Val  Leu Ser Xaa Phe Tyr  Ser Gln Arg Glu Lys  Pro Gly Ile 
    1145                 1150                 1155             


Phe Tyr  Gln Gln Xaa Leu Pro  Gly Ser His Ile Pro  Glu Glu Ala 
    1160                 1165                 1170             


Gln Lys  Val Ser Pro Val Leu  Gly Pro Ala Asp Gln  Lys Xaa Gly 
    1175                 1180                 1185             


Xaa Pro  Xaa Pro Xaa Ser Ala  Ser Tyr Ser His Xaa  Glu Lys Pro 
    1190                 1195                 1200             


Gly Ile  Phe Tyr Gln Gln Val  Leu Pro Asp Asn His  Pro Xaa Glu 
    1205                 1210                 1215             


Glu Ala  Leu Lys Ile Ser Val  Ala Ser Glu Pro Val  Asp Gln Xaa 
    1220                 1225                 1230             


Xaa Gly  Xaa Pro Ala Val Xaa  Ser Xaa Ser Tyr Ser  Gln Tyr Arg 
    1235                 1240                 1245             


Glu Lys  Pro Ser Ile Phe Tyr  Gln Gln Ser Leu Pro  Ser Ser His 
    1250                 1255                 1260             


Leu Xaa  Glu Glu Ala Lys Asn  Val Ser Ala Val Pro  Gly Pro Ala 
    1265                 1270                 1275             


Asp Gln  Lys Xaa Val Ile Pro  Ile Leu Pro Ser Xaa  Phe Tyr Ser 
    1280                 1285                 1290             


His Xaa  Glu Lys Pro Gly Val  Phe Tyr Gln Gln Val  Leu Pro His 
    1295                 1300                 1305             


Ser His  Pro Xaa Glu Glu Ala  Leu Lys Ile Ser Val  Ala Ser Glu 
    1310                 1315                 1320             


Pro Val  Asp Gln Xaa Xaa Gly  Xaa Pro Xaa Val Xaa  Ser Xaa Ser 
    1325                 1330                 1335             


Tyr Ser  Gln His Xaa Glu Lys  Pro Ser Ile Phe Tyr  Gln Gln Ser 
    1340                 1345                 1350             


Leu Pro  Gly Ser His Leu Xaa  Glu Glu Ala Lys Asn  Val Ser Ala 
    1355                 1360                 1365             


Val Pro  Gly Pro Gly Asp Arg  Lys Xaa Gly Ile Pro  Xaa Leu Pro 
    1370                 1375                 1380             


Ser Xaa  Phe Tyr Ser His Xaa  Glu Lys Pro Gly Ser  Phe Tyr Gln 
    1385                 1390                 1395             


Gln Val  Leu Pro His Ser His  Leu Pro Glu Glu Ala  Leu Glu Val 
    1400                 1405                 1410             


Ser Val  Ala Pro Gly Pro Val  Asp Gln Xaa Ile Gly  Xaa Pro Xaa 
    1415                 1420                 1425             


Val Xaa  Ser Pro Ser Ser Ser  Phe Gly Glu Lys Pro  Ile Val Ile 
    1430                 1435                 1440             


Tyr Lys  Gln Ala Phe Pro Glu  Gly His Leu Pro Glu  Glu Ser Leu 
    1445                 1450                 1455             


Lys Val  Ser Val Ala Pro Gly  Pro Val Gly Gln Xaa  Xaa Gly Ala 
    1460                 1465                 1470             


Pro Xaa  Ile Xaa Ser Pro Ser  Tyr Ser Gln His Arg  Ala Lys Ser 
    1475                 1480                 1485             


Gly Ser  Phe Tyr Gln Leu Ala  Leu Leu Gly Ser Gln  Ile Pro Glu 
    1490                 1495                 1500             


Glu Ala  Leu Arg Val Ser Ser  Ala Pro Gly Pro Ala  Asp Gln Xaa 
    1505                 1510                 1515             


Xaa Gly  Ile Pro Xaa Ile Xaa  Ser Xaa Ser Tyr Ser  Phe Gly Glu 
    1520                 1525                 1530             


Lys Pro  Ile Val Asn Tyr Lys  Gln Ala Phe Pro Asp  Gly His Leu 
    1535                 1540                 1545             


Pro Glu  Glu Ala Leu Lys Val  Ser Ile Val Ser Gly  Pro Xaa Glu 
    1550                 1555                 1560             


Lys Lys  Xaa Asp Ile Pro Ala  Gly Pro Leu Gly Ser  Ser Ala Leu 
    1565                 1570                 1575             


Gly Glu  Lys Pro Ile Xaa Phe  Tyr Arg Gln Ala Leu  Leu Asp Ser 
    1580                 1585                 1590             


Pro Leu  Asn Lys Glu Val Val  Lys Val Ser Ala Ala  Pro Gly Pro 
    1595                 1600                 1605             


Ala Asp  Gln Lys Xaa Glu Xaa  Leu Pro Val His Ser  Xaa Ser Tyr 
    1610                 1615                 1620             


Ser Asn  Arg Gly Lys Pro Val  Ile Phe Tyr Gln Gln  Xaa Leu Ser 
    1625                 1630                 1635             


Asp Ser  His Leu Pro Glu Glu  Ala Leu Lys Val Pro  Pro Val Pro 
    1640                 1645                 1650             


Gly Pro  Asp Ala Gln Lys Xaa  Glu Xaa Pro Ser Val  Ser Ser Ser 
    1655                 1660                 1665             


Leu Tyr  Ser Tyr Arg Glu Lys  Pro Ile Val Phe Tyr  Gln Gln Ala 
    1670                 1675                 1680             


Leu Pro  Asp Ser Glu Leu Xaa  Gln Glu Ala Leu Lys  Val Ser Ala 
    1685                 1690                 1695             


Val Pro  Gln Pro Ala Asp Gln  Lys Xaa Gly Leu Ser  Xaa Val Xaa 
    1700                 1705                 1710             


Ser Ser  Phe Tyr Ser His Xaa  Glu Lys Pro Asn Ile  Ser Tyr Gln 
    1715                 1720                 1725             


Gln Glu  Leu Pro Asp Ser His  Leu Xaa Glu Glu Ala  Leu Lys Val 
    1730                 1735                 1740             


Ser Asn  Val Pro Gly Pro Ala  Asp Gln Lys Xaa Gly  Val Ser Xaa 
    1745                 1750                 1755             


Val Xaa  Ser Xaa Ser Tyr Ser  His Arg Glu Lys Pro  Ile Val Ser 
    1760                 1765                 1770             


Tyr Gln  Arg Glu Leu Pro His  Phe Xaa Glu Ala Gly  Leu Lys Ile 
    1775                 1780                 1785             


Leu Arg  Val Pro Gly Pro Ala  Asp Gln Lys Xaa Gly  Ile Asn Ile 
    1790                 1795                 1800             


Leu Pro  Ser Asn Ser Tyr Pro  Gln Arg Glu His Ser  Val Ile Ser 
    1805                 1810                 1815             


Tyr Glu  Gln Glu Leu Pro Asp  Leu Xaa Glu Val Xaa  Leu Lys Ala 
    1820                 1825                 1830             


Ile Gly  Val Pro Gly Pro Ala  Asp Gln Lys Xaa Gly  Ile Gln Ile 
    1835                 1840                 1845             


Ala Ser  Ser Ser Ser Tyr Ser  Asn Arg Glu Lys Ala  Ser Ile Phe 
    1850                 1855                 1860             


His Gln  Gln Glu Leu Pro Asp  Val Xaa Glu Glu Ala  Leu Asn Val 
    1865                 1870                 1875             


Phe Val  Val Pro Gly Gln Gly  Asp Arg Lys Xaa Glu  Ile Pro Xaa 
    1880                 1885                 1890             


Val Pro  Leu Ser Tyr Tyr Ser  Arg Arg Glu Lys Pro  Ser Val Ile 
    1895                 1900                 1905             


Ser Gln  Gln Glu Leu Pro Asp  Ser His Leu Xaa Glu  Glu Ala Leu 
    1910                 1915                 1920             


Lys Val  Ser Pro Val Ser Ile  Pro Ala Glu Gln Lys  Xaa Gly Ile 
    1925                 1930                 1935             


Pro Ile  Gly Leu Ser Ser Ser  Tyr Ser His Ser His  Lys Glu Lys 
    1940                 1945                 1950             


Leu Lys  Ile Ser Xaa Val His  Ile Pro Asp Asp Gln  Lys Xaa Glu 
    1955                 1960                 1965             


Phe Pro  Ala Ala Xaa Leu Ser  Ser Tyr Ser Gln Ile  Glu Lys Pro 
    1970                 1975                 1980             


Lys Ile  Ser Xaa Val Ile Gly  Pro Asn Asp Gln Lys  Xaa Pro Ser 
    1985                 1990                 1995             


Gln Xaa  Ala Phe His Ser Ser  Tyr Ser Gln Xaa Val  Lys Pro Asn 
    2000                 2005                 2010             


Ile Leu  Phe Gln Gln Gln Leu  Pro Asp Arg Asp Gln  Ser Lys Gly 
    2015                 2020                 2025             


Ile Leu  Lys Ile Ser Ala Val  Pro Glu Leu Xaa Asp  Val Asn Xaa 
    2030                 2035                 2040             


Gly Lys  Pro Val Ser Leu Ser  Ser Ser Tyr Phe His  Arg Glu Lys 
    2045                 2050                 2055             


Ser Asn  Ile Phe Ser Pro Gln  Glu Leu Pro Gly Ser  His Val Xaa 
    2060                 2065                 2070             


Glu Asp  Val Leu Lys Val Ser  Xaa Ile Pro Gly Pro  Ala Gly Gln 
    2075                 2080                 2085             


Lys Xaa  Val Leu Pro Xaa Ala  Leu Pro Ser Ser Phe  Ser His Arg 
    2090                 2095                 2100             


Glu Lys  Pro Asp Ile Phe Tyr  Gln Lys Asp Leu Pro  Asp Arg His 
    2105                 2110                 2115             


Leu Xaa  Glu Asp Ala Leu Lys  Ile Ser Ser Ala Leu  Gly Gln Ala 
    2120                 2125                 2130             


Asp Gln  Ile Xaa Gly Leu Gln  Xaa Val Pro Ser Gly  Xaa Tyr Ser 
    2135                 2140                 2145             


His Gly  Glu Asn His Lys Leu  Val Ser Glu His Val  Gln Arg Leu 
    2150                 2155                 2160             


Ile Asp  Asn Leu Asn Ser Ser  Asp Ser Ser Val Ser  Ser Asn Asn 
    2165                 2170                 2175             


Val Leu  Leu Asn Ser Gln Ala  Asp Asp Arg Val Val  Ile Asn Lys 
    2180                 2185                 2190             


Pro Glu  Ser Ala Gly Phe Arg  Asp Val Gly Ser Glu  Glu Ile Gln 
    2195                 2200                 2205             


Asp Ala  Glu Asn Ser Ala Lys  Xaa Leu Lys Glu Ile  Arg Xaa Leu 
    2210                 2215                 2220             


Leu Met  Glu Ala Glu Asn Met  Ala Leu Lys Arg Cys  Asn Phe Pro 
    2225                 2230                 2235             


Ala Pro  Leu Ala Arg Phe Arg  Asp Ile Ser Asp Ile  Ser Phe Ile 
    2240                 2245                 2250             


Gln Ser  Lys Lys Val Val Cys  Phe Lys Glu Pro Ser  Ser Xaa Gly 
    2255                 2260                 2265             


Val Ser  Asn Gly Asp Leu Leu  His Arg Gln Pro Phe  Xaa Glu Glu 
    2270                 2275                 2280             


Ser Pro  Ser Ser Arg Cys Ile  Gln Lys Asp Ile Gly  Xaa Gln Xaa 
    2285                 2290                 2295             


Asn Leu  Lys Cys Arg Arg Gly  Ile Glu Asn Trp Glu  Phe Ile Ser 
    2300                 2305                 2310             


Ser Xaa  Xaa Val Arg Ser Pro  Leu Gln Glu Ala Glu  Ser Lys Val 
    2315                 2320                 2325             


Ser Met  Ala Leu Glu Glu Xaa  Leu Arg Gln Tyr Gln  Ala Ala Lys 
    2330                 2335                 2340             


Ser Val  Met Arg Ser Glu Pro  Glu Gly Cys Ser Gly  Xaa Ile Gly 
    2345                 2350                 2355             


Asn Lys  Ile Ile Ile Pro Met  Met Xaa Val Ile Lys  Ser Asp Ser 
    2360                 2365                 2370             


Ser Ser  Asp Ala Ser Asp Gly  Asn Gly Ser Cys Ser  Trp Asp Ser 
    2375                 2380                 2385             


Asn Leu  Pro Glu Ser Leu Glu  Ser Val Ser Asp Val  Leu Leu Asn 
    2390                 2395                 2400             


Phe Phe  Pro Tyr Val Ser Pro  Lys Xaa Ser Ile Xaa  Asp Ser Arg 
    2405                 2410                 2415             


Glu Glu  Glu Gly Val Ser Glu  Ser Glu Asp Gly Gly  Gly Ser Ser 
    2420                 2425                 2430             


Val Asp  Ser Leu Ala Ala His  Val Lys Asn Leu Leu  Gln Cys Glu 
    2435                 2440                 2445             


Ser Ser  Leu Asn His Ala Lys  Glu Ile Leu Arg Asn  Ala Glu Glu 
    2450                 2455                 2460             


Glu Glu  Ser Arg Val Arg Ala  His Ala Trp Asn Met  Lys Phe Asn 
    2465                 2470                 2475             


Leu Ala  His Asp Cys Gly Tyr  Ser Ile Ser Glu Leu  Asn Glu Asp 
    2480                 2485                 2490             


Asp Arg  Arg Lys Val Glu Glu  Ile Lys Ala Glu Leu  Phe Gly His 
    2495                 2500                 2505             


Gly Arg  Xaa Xaa Asp Leu Ser  Lys Gly Leu Gln Ser  Pro Arg Gly 
    2510                 2515                 2520             


Met Gly  Cys Lys Pro Glu Ala  Val Cys Ser His Ile  Ile Ile Glu 
    2525                 2530                 2535             


Ser His  Glu Lys Gly Cys Phe  Arg Xaa Leu Xaa Ser  Glu His Pro 
    2540                 2545                 2550             


Gln Leu  Asp Arg His Pro Cys  Ala Phe Arg Ser Ala  Gly Pro Ser 
    2555                 2560                 2565             


Glu Met  Xaa Arg Gly Arg Gln  Asn Pro Ser Ser Cys  Arg Ala Lys 
    2570                 2575                 2580             


His Val  Asn Leu Ser Ala Ser  Leu Asp Gln Asn Asn  Ser His Phe 
    2585                 2590                 2595             


Lys Val  Trp Asn Ser Leu Gln  Leu Lys Ser His Ser  Pro Phe Gln 
    2600                 2605                 2610             


Asn Phe  Ile Pro Asp Glu Phe  Lys Ile Ser Lys Gly  Leu Arg Met 
    2615                 2620                 2625             


Pro Phe  Asp Glu Lys Met Asp  Pro Trp Leu Ser Glu  Leu Val Glu 
    2630                 2635                 2640             


Pro Ala  Phe Val Pro Pro Lys  Glu Val Asp Phe His  Ser Ser Ser 
    2645                 2650                 2655             


Gln Met  Pro Ser Pro Glu Pro  Met Lys Lys Phe Xaa  Xaa Ser Ile 
    2660                 2665                 2670             


Xaa Phe  Ser Ser His Arg His  Ser Lys Cys Ile Ser  Asn Ser Ser 
    2675                 2680                 2685             


Val Val  Lys Val Gly Val Xaa  Glu Gly Ser Gln Cys  Xaa Gly Ala 
    2690                 2695                 2700             


Ser Val  Gly Val Phe Asn Ser  His Phe Xaa Glu Glu  Gln Asn Pro 
    2705                 2710                 2715             


Pro Arg  Asp Leu Lys Gln Lys  Xaa Ser Ser Pro Ser  Ser Phe Lys 
    2720                 2725                 2730             


Met His  Ser Asn Ser Gln Asp  Lys Glu Val Xaa Ile  Leu Ala Glu 
    2735                 2740                 2745             


Gly Arg  Arg Gln Ser Gln Lys  Leu Pro Val Asp Phe  Glu Arg Ser 
    2750                 2755                 2760             


Phe Gln  Glu Glu Lys Pro Leu  Glu Arg Ser Asp Phe  Xaa Gly Ser 
    2765                 2770                 2775             


His Ser  Glu Pro Ser Xaa Arg  Ala Asn Cys Ser Asn  Phe Lys Glu 
    2780                 2785                 2790             


Ile Gln  Ile Ser Asp Asn His  Xaa Leu Ile Ser Met  Gly Arg Pro 
    2795                 2800                 2805             


Ser Ser  Xaa Leu Gly Val Asn  Arg Ser Ser Ser Arg  Leu Gly Val 
    2810                 2815                 2820             


Lys Glu  Lys Asn Val Xaa Ile  Xaa Pro Asp Leu Pro  Ser Cys Ile 
    2825                 2830                 2835             


Phe Leu  Glu Gln Arg Glu Leu  Phe Glu Gln Ser Lys  Ala Pro Arg 
    2840                 2845                 2850             


Ala Asp  Asp His Val Arg Lys  His His Ser Pro Ser  Pro Gln His 
    2855                 2860                 2865             


Gln Asp  Tyr Val Ala Pro Asp  Leu Pro Ser Cys Ile  Phe Leu Glu 
    2870                 2875                 2880             


Gln Arg  Glu Leu Phe Glu Gln  Cys Lys Ala Pro Tyr  Val Asp His 
    2885                 2890                 2895             


Gln Met  Arg Glu Asn His Ser  Pro Leu Pro Gln Gly  Gln Asp Ser 
    2900                 2905                 2910             


Ile Ala  Ser Asp Leu Pro Ser  Pro Ile Ser Leu Glu  Gln Cys Gln 
    2915                 2920                 2925             


Ser Lys  Ala Pro Gly Val Asp  Asp Gln Met Asn Lys  His His Phe 
    2930                 2935                 2940             


Pro Leu  Pro Gln Gly Gln Asp  Cys Val Val Glu Lys  Asn Asn Gln 
    2945                 2950                 2955             


His Lys  Pro Lys Ser His Ile  Ser Asn Ile Asn Val  Glu Ala Lys 
    2960                 2965                 2970             


Phe Asn  Xaa Val Val Ser Gln  Ser Ala Pro Asn His  Cys Xaa Leu 
    2975                 2980                 2985             


Ala Ala  Ser Ala Ser Xaa Pro  Pro Ser Asn Arg Lys  Ala Leu Ser 
    2990                 2995                 3000             


Cys Val  His Ile Xaa Leu Cys  Pro Lys Xaa Ser Ser  Lys Leu Asp 
    3005                 3010                 3015             


Ser Gly  Xaa Leu Asp Glu Arg  Phe His Ser Leu Asp  Ala Ala Ser 
    3020                 3025                 3030             


Lys Ala  Arg Met Asn Ser Glu  Phe Asn Phe Asp Leu  His Xaa Val 
    3035                 3040                 3045             


Ser Ser  Arg Ser Leu Glu Pro  Xaa Ser Lys Leu Leu  Xaa Ser Lys 
    3050                 3055                 3060             


Pro Val  Ala Gln Asp Gln Glu  Ser Leu Gly Phe Leu  Gly Pro Lys 
    3065                 3070                 3075             


Ser Ser  Leu Asp Phe Gln Val  Val Gln Pro Ser Leu  Pro Asp Ser 
    3080                 3085                 3090             


Asn Xaa  Ile Xaa Gln Asp Leu  Lys Xaa Ile Pro Ser  Gln Asn Ser 
    3095                 3100                 3105             


Gln Ile  Val Xaa Ser Arg Gln  Ile Gln Val Asn Ile  Ser Asp Phe 
    3110                 3115                 3120             


Glu Gly  His Ser Asn Pro Glu  Gly Xaa Pro Val Phe  Ala Asp Arg 
    3125                 3130                 3135             


Leu Pro  Glu Lys Met Lys Xaa  Pro Leu Ser Ala Phe  Ser Glu Lys 
    3140                 3145                 3150             


Leu Ser  Ser Asp Ala Val Xaa  Gln Ile Xaa Xaa Glu  Ser Pro Glu 
    3155                 3160                 3165             


Lys Xaa  Leu Phe Ser Ser Glu  Ile Phe Ile Asn Ala  Glu Asp Arg 
    3170                 3175                 3180             


Gly His  Glu Ile Ile Glu Pro  Gly Asn Gln Lys Leu  Arg Lys Ala 
    3185                 3190                 3195             


Pro Val  Lys Phe Ala Ser Ser  Ser Ser Val Gln Gln  Val Xaa Phe 
    3200                 3205                 3210             


Ser Arg  Gly Xaa Asp Gly Gln  Pro Leu Leu Leu Pro  Tyr Lys Pro 
    3215                 3220                 3225             


Ser Gly  Ser Xaa Lys Met Tyr  Tyr Val Pro Gln Leu  Arg Gln Ile 
    3230                 3235                 3240             


Pro Pro  Ser Pro Asp Ser Lys  Ser Asp Xaa Xaa Val  Glu Ser Ser 
    3245                 3250                 3255             


His Ser  Gly Ser Asn Asp Ala  Ile Ala Pro Asp Phe  Pro Ala Gln 
    3260                 3265                 3270             


Val Leu  Gly Xaa Arg Asp Asp  Asp Leu Ser Ala Xaa  Val Asn Ile 
    3275                 3280                 3285             


Lys His  Lys Glu Gly Ile Tyr  Ser Lys Arg Val Val  Xaa Lys Ala 
    3290                 3295                 3300             


Ser Leu  Pro Val Gly Glu Lys  Pro Leu Gln Asn Glu  Asn Ala Asp 
    3305                 3310                 3315             


Ala Ser  Val Gln Val Leu Ile  Xaa Gly Asp Glu Asn  Leu Ser Asp 
    3320                 3325                 3330             


Lys Lys  Gln Gln Glu Ile His  Ser Xaa Arg Ala Val  Xaa Glu Ala 
    3335                 3340                 3345             


Ala Gln  Ala Lys Glu Lys Glu  Ser Leu Gln Lys Asp  Xaa Ala Asp 
    3350                 3355                 3360             


Ser Ser  Ala Ala Ala Ala Ala  Glu His Ser Ala Gln  Val Gly Asp 
    3365                 3370                 3375             


Pro Glu  Met Lys Asn Leu Pro  Asp Xaa Lys Ala Ile  Xaa Gln Lys 
    3380                 3385                 3390             


Glu Glu  Ile His Arg Lys Lys  Xaa Val Pro Glu Glu  Ala Trp Pro 
    3395                 3400                 3405             


Asn Asn  Lys Glu Ser Leu Gln  Ile Asn Ile Glu Glu  Ser Glu Cys 
    3410                 3415                 3420             


His Ser  Glu Phe Glu Asn Xaa  Xaa Arg Ser Val Phe  Arg Ser Ala 
    3425                 3430                 3435             


Lys Phe  Tyr Ile His His Pro  Val His Leu Pro Ser  Asp Gln Asp 
    3440                 3445                 3450             


Ile Cys  His Glu Ser Leu Gly  Lys Ser Val Phe Met  Arg His Ser 
    3455                 3460                 3465             


Trp Lys  Asp Phe Phe Gln His  His Pro Asp Lys His  Arg Glu His 
    3470                 3475                 3480             


Met Cys  Leu Pro Leu Pro Tyr  Gln Asn Met Asp Lys  Xaa Lys Xaa 
    3485                 3490                 3495             


Asp Tyr  Xaa Arg Ile Lys Ser  Leu Ser Ile Asn Val  Asn Leu Gly 
    3500                 3505                 3510             


Asn Lys  Glu Val Met Asp Xaa  Xaa Lys Ser Gln Val  Arg Asp Tyr 
    3515                 3520                 3525             


Pro Lys  His Asn Gly Gln Ile  Ser Asp Pro Gln Arg  Asp Gln Lys 
    3530                 3535                 3540             


Val Xaa  Pro Glu Gln Xaa Xaa  Gln His Xaa Val Ser  Leu Asn Glu 
    3545                 3550                 3555             


Leu Trp  Asn Lys Tyr Arg Glu  Arg Gln Arg Gln Gln  Arg Gln Pro 
    3560                 3565                 3570             


Glu Leu  Gly Asp Arg Lys Glu  Leu Ser Leu Val Asp  Arg Leu Asp 
    3575                 3580                 3585             


Arg Leu  Ala Lys Ile Leu Gln  Asn Pro Ile Xaa His  Ser Leu Gln 
    3590                 3595                 3600             


Val Ser  Glu Ser Xaa His Asp  Asp Ser Arg Gly Glu  Arg Ser Val 
    3605                 3610                 3615             


Lys Glu  Trp Ser Gly Arg Gln  Gln Gln Arg Asn Lys  Leu Gln Lys 
    3620                 3625                 3630             


Lys Lys  Arg Phe Lys Ser Leu  Glu Lys Ser His Lys  Asn Xaa Gly 
    3635                 3640                 3645             


Glu Leu  Lys Lys Ser Lys Val  Leu Ser His His Arg  Ala Gly Arg 
    3650                 3655                 3660             


Ser Asn  Gln Ile Lys Ile Glu  Gln Ile Lys Phe Asp  Lys Tyr Ile 
    3665                 3670                 3675             


Leu Ser  Lys Gln Pro Gly Phe  Asn Tyr Ile Ser Asn  Xaa Ser Ser 
    3680                 3685                 3690             


Asp Cys  Arg Pro Ser Glu Glu  Ser Glu Leu Leu Xaa  Asp Xaa Xaa 
    3695                 3700                 3705             


Xaa Asn  Ile Leu Ser Gly Xaa  Xaa Ser Xaa Val Glu  Ser Asp Ile 
    3710                 3715                 3720             


Leu Xaa  Gln Xaa Asp Arg Glu  Val Ala Leu His Glu  Arg Ser Ser 
    3725                 3730                 3735             


Ser Val  Ser Xaa Ile Asp Xaa  Ala Arg Leu Ile Gln  Ala Phe Gly 
    3740                 3745                 3750             


His Glu  Arg Val Cys Leu Ser  Pro Arg Arg Ile Lys  Leu Tyr Ser 
    3755                 3760                 3765             


Ser Ile  Xaa Asn Gln Gln Arg  Arg Tyr Leu Glu Lys  Arg Ser Lys 
    3770                 3775                 3780             


His Ser  Lys Lys Val Leu Asn  Xaa Gly His Pro Leu  Val Xaa Ser 
    3785                 3790                 3795             


Glu His  Xaa Arg Arg Arg His  Ile Gln Val Ala Asn  His Val Ile 
    3800                 3805                 3810             


Ser Ser  Asp Ser Ile Ser Ser  Ser Ala Ser Ser Phe  Leu Ser Ser 
    3815                 3820                 3825             


Asn Ser  Xaa Phe Cys Asn Lys  Gln Asn Val His Met  Leu Asn Lys 
    3830                 3835                 3840             


Gly Ile  Gln Ala Gly Asn Leu  Glu Ile Val Asn Gly  Ala Lys Lys 
    3845                 3850                 3855             


His Xaa  Arg Asp Val Gly Ile  Xaa Phe Pro Xaa Pro  Ser Ser Ser 
    3860                 3865                 3870             


Glu Ala  Lys Leu Glu Glu Asn  Ser Asp Val Xaa Ser  Trp Ser Glu 
    3875                 3880                 3885             


Glu Lys  Arg Glu Glu Lys Met  Leu Phe Xaa Gly Tyr  Pro Glu Asp 
    3890                 3895                 3900             


Arg Lys  Leu Lys Lys Asn Lys  Lys Asn Ser His Glu  Gly Val Ser 
    3905                 3910                 3915             


Trp Phe  Val Pro Val Glu Asn  Val Glu Ser Arg Ser  Lys Lys Glu 
    3920                 3925                 3930             


Asn Val  Pro Asn Xaa Cys Gly  Pro Gly Ile Ser Trp  Phe Glu Pro 
    3935                 3940                 3945             


Ile Xaa  Lys Xaa Arg Pro Trp  Arg Glu Pro Leu Arg  Glu Gln Asn 
    3950                 3955                 3960             


Cys Gln  Gly Gln His Leu Asp  Gly Arg Gly Tyr Leu  Ala Gly Pro 
    3965                 3970                 3975             


Gly Arg  Glu Ala Gly Arg Asp  Leu Leu Arg Pro Phe  Val Arg Ala 
    3980                 3985                 3990             


Xaa Leu  Gln Glu Ser Leu Gln  Phe His Arg Pro Asp  Phe Ile Ser 
    3995                 4000                 4005             


Arg Ser  Gly Glu Arg Ile Lys  Arg Leu Lys Leu Ile  Val Gln Glu 
    4010                 4015                 4020             


Arg Lys  Leu Gln Ser Met Leu  Gln Xaa Glu Arg Asp  Ala Leu Phe 
    4025                 4030                 4035             


Asn Ile  Asp Arg Glu Arg Gln  Gly His Gln Asn Arg  Met Cys Pro 
    4040                 4045                 4050             


Leu Pro  Lys Arg Val Phe Leu  Ala Ile Gln Lys Asn  Lys Pro Ile 
    4055                 4060                 4065             


Ser Lys  Lys Glu Met Ile Gln  Arg Ser Lys Arg Ile  Tyr Glu Gln 
    4070                 4075                 4080             


Leu Pro  Glu Val Gln Lys Lys  Arg Glu Glu Glu Lys  Arg Lys Ser 
    4085                 4090                 4095             


Glu Tyr  Lys Ser Tyr Arg Leu  Arg Ala Gln Leu Tyr  Lys Lys Arg 
    4100                 4105                 4110             


Val Xaa  Asn Gln Leu Leu Gly  Arg Lys Val Pro Trp  Asp 
    4115                 4120                 4125     


<210> 2212
<211> 1023
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<400> 2212
Gln Ala Leu Pro Asp Ser Glu Leu Xaa Gln Glu Ala Leu Lys Val Ser 
1               5                   10                  15      


Ala Val Pro Gln Pro Ala Asp Gln Lys Xaa Gly Leu Ser Xaa Val Xaa 
            20                  25                  30          


Ser Ser Phe Tyr Ser His Xaa Glu Lys Pro Asn Ile Ser Tyr Gln Gln 
        35                  40                  45              


Glu Leu Pro Asp Ser His Leu Xaa Glu Glu Ala Leu Lys Val Ser Asn 
    50                  55                  60                  


Val Pro Gly Pro Ala Asp Gln Lys Xaa Gly Val Ser Xaa Val Xaa Ser 
65                  70                  75                  80  


Xaa Ser Tyr Ser His Arg Glu Lys Pro Ile Val Ser Tyr Gln Arg Glu 
                85                  90                  95      


Leu Pro His Phe Xaa Glu Ala Gly Leu Lys Ile Leu Arg Val Pro Gly 
            100                 105                 110         


Pro Ala Asp Gln Lys Xaa Gly Ile Asn Ile Leu Pro Ser Asn Ser Tyr 
        115                 120                 125             


Pro Gln Arg Glu His Ser Val Ile Ser Tyr Glu Gln Glu Leu Pro Asp 
    130                 135                 140                 


Leu Xaa Glu Val Xaa Leu Lys Ala Ile Gly Val Pro Gly Pro Ala Asp 
145                 150                 155                 160 


Gln Lys Xaa Gly Ile Gln Ile Ala Ser Ser Ser Ser Tyr Ser Asn Arg 
                165                 170                 175     


Glu Lys Ala Ser Ile Phe His Gln Gln Glu Leu Pro Asp Val Xaa Glu 
            180                 185                 190         


Glu Ala Leu Asn Val Phe Val Val Pro Gly Gln Gly Asp Arg Lys Xaa 
        195                 200                 205             


Glu Ile Pro Xaa Val Pro Leu Ser Tyr Tyr Ser Arg Arg Glu Lys Pro 
    210                 215                 220                 


Ser Val Ile Ser Gln Gln Glu Leu Pro Asp Ser His Leu Xaa Glu Glu 
225                 230                 235                 240 


Ala Leu Lys Val Ser Pro Val Ser Ile Pro Ala Glu Gln Lys Xaa Gly 
                245                 250                 255     


Ile Pro Ile Gly Leu Ser Ser Ser Tyr Ser His Ser His Lys Glu Lys 
            260                 265                 270         


Leu Lys Ile Ser Xaa Val His Ile Pro Asp Asp Gln Lys Xaa Glu Phe 
        275                 280                 285             


Pro Ala Ala Xaa Leu Ser Ser Tyr Ser Gln Ile Glu Lys Pro Lys Ile 
    290                 295                 300                 


Ser Xaa Val Ile Gly Pro Asn Asp Gln Lys Xaa Pro Ser Gln Xaa Ala 
305                 310                 315                 320 


Phe His Ser Ser Tyr Ser Gln Xaa Val Lys Pro Asn Ile Leu Phe Gln 
                325                 330                 335     


Gln Gln Leu Pro Asp Arg Asp Gln Ser Lys Gly Ile Leu Lys Ile Ser 
            340                 345                 350         


Ala Val Pro Glu Leu Xaa Asp Val Asn Xaa Gly Lys Pro Val Ser Leu 
        355                 360                 365             


Ser Ser Ser Tyr Phe His Arg Glu Lys Ser Asn Ile Phe Ser Pro Gln 
    370                 375                 380                 


Glu Leu Pro Gly Ser His Val Xaa Glu Asp Val Leu Lys Val Ser Xaa 
385                 390                 395                 400 


Ile Pro Gly Pro Ala Gly Gln Lys Xaa Val Leu Pro Xaa Ala Leu Pro 
                405                 410                 415     


Ser Ser Phe Ser His Arg Glu Lys Pro Asp Ile Phe Tyr Gln Lys Asp 
            420                 425                 430         


Leu Pro Asp Arg His Leu Xaa Glu Asp Ala Leu Lys Ile Ser Ser Ala 
        435                 440                 445             


Leu Gly Gln Ala Asp Gln Ile Xaa Gly Leu Gln Xaa Val Pro Ser Gly 
    450                 455                 460                 


Xaa Tyr Ser His Gly Glu Asn His Lys Leu Val Ser Glu His Val Gln 
465                 470                 475                 480 


Arg Leu Ile Asp Asn Leu Asn Ser Ser Asp Ser Ser Val Ser Ser Asn 
                485                 490                 495     


Asn Val Leu Leu Asn Ser Gln Ala Asp Asp Arg Val Val Ile Asn Lys 
            500                 505                 510         


Pro Glu Ser Ala Gly Phe Arg Asp Val Gly Ser Glu Glu Ile Gln Asp 
        515                 520                 525             


Ala Glu Asn Ser Ala Lys Xaa Leu Lys Glu Ile Arg Xaa Leu Leu Met 
    530                 535                 540                 


Glu Ala Glu Asn Met Ala Leu Lys Arg Cys Asn Phe Pro Ala Pro Leu 
545                 550                 555                 560 


Ala Arg Phe Arg Asp Ile Ser Asp Ile Ser Phe Ile Gln Ser Lys Lys 
                565                 570                 575     


Val Val Cys Phe Lys Glu Pro Ser Ser Xaa Gly Val Ser Asn Gly Asp 
            580                 585                 590         


Leu Leu His Arg Gln Pro Phe Xaa Glu Glu Ser Pro Ser Ser Arg Cys 
        595                 600                 605             


Ile Gln Lys Asp Ile Gly Xaa Gln Xaa Asn Leu Lys Cys Arg Arg Gly 
    610                 615                 620                 


Ile Glu Asn Trp Glu Phe Ile Ser Ser Xaa Xaa Val Arg Ser Pro Leu 
625                 630                 635                 640 


Gln Glu Ala Glu Ser Lys Val Ser Met Ala Leu Glu Glu Xaa Leu Arg 
                645                 650                 655     


Gln Tyr Gln Ala Ala Lys Ser Val Met Arg Ser Glu Pro Glu Gly Cys 
            660                 665                 670         


Ser Gly Xaa Ile Gly Asn Lys Ile Ile Ile Pro Met Met Xaa Val Ile 
        675                 680                 685             


Lys Ser Asp Ser Ser Ser Asp Ala Ser Asp Gly Asn Gly Ser Cys Ser 
    690                 695                 700                 


Trp Asp Ser Asn Leu Pro Glu Ser Leu Glu Ser Val Ser Asp Val Leu 
705                 710                 715                 720 


Leu Asn Phe Phe Pro Tyr Val Ser Pro Lys Xaa Ser Ile Xaa Asp Ser 
                725                 730                 735     


Arg Glu Glu Glu Gly Val Ser Glu Ser Glu Asp Gly Gly Gly Ser Ser 
            740                 745                 750         


Val Asp Ser Leu Ala Ala His Val Lys Asn Leu Leu Gln Cys Glu Ser 
        755                 760                 765             


Ser Leu Asn His Ala Lys Glu Ile Leu Arg Asn Ala Glu Glu Glu Glu 
    770                 775                 780                 


Ser Arg Val Arg Ala His Ala Trp Asn Met Lys Phe Asn Leu Ala His 
785                 790                 795                 800 


Asp Cys Gly Tyr Ser Ile Ser Glu Leu Asn Glu Asp Asp Arg Arg Lys 
                805                 810                 815     


Val Glu Glu Ile Lys Ala Glu Leu Phe Gly His Gly Arg Xaa Xaa Asp 
            820                 825                 830         


Leu Ser Lys Gly Leu Gln Ser Pro Arg Gly Met Gly Cys Lys Pro Glu 
        835                 840                 845             


Ala Val Cys Ser His Ile Ile Ile Glu Ser His Glu Lys Gly Cys Phe 
    850                 855                 860                 


Arg Xaa Leu Xaa Ser Glu His Pro Gln Leu Asp Arg His Pro Cys Ala 
865                 870                 875                 880 


Phe Arg Ser Ala Gly Pro Ser Glu Met Xaa Arg Gly Arg Gln Asn Pro 
                885                 890                 895     


Ser Ser Cys Arg Ala Lys His Val Asn Leu Ser Ala Ser Leu Asp Gln 
            900                 905                 910         


Asn Asn Ser His Phe Lys Val Trp Asn Ser Leu Gln Leu Lys Ser His 
        915                 920                 925             


Ser Pro Phe Gln Asn Phe Ile Pro Asp Glu Phe Lys Ile Ser Lys Gly 
    930                 935                 940                 


Leu Arg Met Pro Phe Asp Glu Lys Met Asp Pro Trp Leu Ser Glu Leu 
945                 950                 955                 960 


Val Glu Pro Ala Phe Val Pro Pro Lys Glu Val Asp Phe His Ser Ser 
                965                 970                 975     


Ser Gln Met Pro Ser Pro Glu Pro Met Lys Lys Phe Xaa Xaa Ser Ile 
            980                 985                 990         


Xaa Phe Ser Ser His Arg His Ser  Lys Cys Ile Ser Asn  Ser Ser Val 
        995                 1000                 1005             


Val Lys  Ile Xaa Arg Glu Asp  Glu Asp Pro Xaa Phe  Cys Phe Leu 
    1010                 1015                 1020             


<210> 2213
<211> 109
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<400> 2213
Met Gly Leu Tyr Arg Ile Arg Val Ser Xaa Gly Ala Ser Leu Tyr Ala 
1               5                   10                  15      


Gly Ser Asn Asn Gln Val Gln Leu Trp Leu Val Gly Gln His Gly Glu 
            20                  25                  30          


Ala Ala Leu Gly Lys Arg Leu Trp Pro Ala Arg Gly Lys Glu Xaa Glu 
        35                  40                  45              


Leu Lys Val Glu Val Pro Glu Tyr Leu Gly Pro Leu Leu Phe Val Lys 
    50                  55                  60                  


Leu Arg Lys Arg His Leu Leu Lys Asp Asp Ala Trp Phe Cys Asn Trp 
65                  70                  75                  80  


Ile Ser Val Gln Gly Pro Gly Ala Gly Asp Glu Val Arg Phe Pro Cys 
                85                  90                  95      


Tyr Arg Trp Val Glu Gly Asn Gly Val Leu Ser Leu Pro 
            100                 105                 


<210> 2214
<211> 662
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<400> 2214
Met Gly Leu Tyr Arg Ile Arg Val Ser Xaa Gly Ala Ser Leu Tyr Ala 
1               5                   10                  15      


Gly Ser Asn Asn Gln Val Gln Leu Trp Leu Val Gly Gln His Gly Glu 
            20                  25                  30          


Ala Ala Leu Gly Lys Arg Leu Trp Pro Ala Arg Gly Lys Glu Xaa Glu 
        35                  40                  45              


Leu Lys Val Glu Val Pro Glu Tyr Leu Gly Pro Leu Leu Phe Val Lys 
    50                  55                  60                  


Leu Arg Lys Arg His Leu Leu Lys Asp Asp Ala Trp Phe Cys Asn Trp 
65                  70                  75                  80  


Ile Ser Val Gln Gly Pro Gly Ala Gly Asp Glu Val Arg Phe Pro Cys 
                85                  90                  95      


Tyr Arg Trp Val Glu Gly Asn Gly Val Leu Ser Leu Pro Glu Gly Xaa 
            100                 105                 110         


Gly Arg Xaa Val Gly Glu Asp Pro Gln Gly Leu Phe Gln Lys His Arg 
        115                 120                 125             


Glu Glu Glu Leu Glu Glu Arg Arg Lys Leu Tyr Arg Trp Gly Asn Trp 
    130                 135                 140                 


Lys Asp Gly Leu Ile Leu Asn Met Ala Gly Ala Lys Leu Tyr Asp Leu 
145                 150                 155                 160 


Pro Val Asp Glu Arg Phe Leu Glu Asp Lys Arg Val Asp Phe Glu Val 
                165                 170                 175     


Ser Leu Ala Lys Gly Leu Ala Asp Leu Ala Ile Lys Asp Ser Leu Asn 
            180                 185                 190         


Val Leu Xaa Cys Trp Lys Asp Leu Asp Asp Phe Asn Arg Ile Phe Trp 
        195                 200                 205             


Cys Gly Gln Ser Lys Leu Ala Glu Arg Val Arg Asp Ser Trp Lys Glu 
    210                 215                 220                 


Asp Ala Leu Phe Gly Tyr Gln Phe Leu Asn Gly Ala Asn Pro Val Val 
225                 230                 235                 240 


Leu Arg Arg Ser Ala His Leu Pro Ala Arg Leu Val Phe Pro Pro Gly 
                245                 250                 255     


Met Glu Glu Leu Gln Ala Gln Leu Glu Lys Glu Leu Glu Gly Gly Xaa 
            260                 265                 270         


Leu Phe Glu Ala Asp Phe Ser Leu Leu Asp Gly Ile Lys Ala Asn Val 
        275                 280                 285             


Ile Leu Cys Ser Gln Gln His Leu Ala Ala Pro Leu Val Met Leu Lys 
    290                 295                 300                 


Leu Gln Pro Asp Gly Lys Leu Leu Pro Met Val Ile Gln Leu Gln Leu 
305                 310                 315                 320 


Pro Arg Xaa Gly Ser Pro Pro Pro Pro Leu Phe Leu Pro Xaa Asp Pro 
                325                 330                 335     


Pro Met Ala Trp Leu Leu Ala Lys Cys Trp Val Arg Ser Ser Asp Phe 
            340                 345                 350         


Gln Leu His Glu Leu Gln Ser His Leu Leu Arg Gly His Leu Met Ala 
        355                 360                 365             


Glu Val Ile Val Val Ala Xaa Met Arg Cys Leu Pro Ser Ile His Pro 
    370                 375                 380                 


Ile Phe Lys Leu Ile Ile Pro His Leu Arg Tyr Xaa Leu Glu Ile Asn 
385                 390                 395                 400 


Val Arg Ala Arg Xaa Gly Leu Val Ser Asp Met Gly Ile Phe Asp Gln 
                405                 410                 415     


Ile Met Ser Xaa Gly Gly Gly Gly His Val Gln Leu Leu Lys Gln Ala 
            420                 425                 430         


Gly Ala Phe Leu Xaa Tyr Ser Ser Phe Cys Pro Pro Asp Asp Leu Ala 
        435                 440                 445             


Asp Arg Gly Leu Leu Gly Val Lys Ser Ser Phe Tyr Ala Gln Asp Ala 
    450                 455                 460                 


Leu Arg Leu Trp Glu Ile Ile Tyr Arg Tyr Val Glu Gly Ile Val Ser 
465                 470                 475                 480 


Leu His Tyr Lys Xaa Asp Val Ala Val Lys Asp Asp Pro Glu Leu Gln 
                485                 490                 495     


Xaa Trp Cys Arg Glu Ile Xaa Glu Ile Gly Leu Gln Gly Ala Gln Asp 
            500                 505                 510         


Arg Gly Phe Pro Val Ser Leu Gln Ala Arg Asp Gln Val Cys His Phe 
        515                 520                 525             


Val Xaa Met Cys Ile Phe Xaa Cys Xaa Gly Gln His Ala Ser Val His 
    530                 535                 540                 


Leu Gly Gln Leu Asp Trp Tyr Ser Trp Val Pro Asn Ala Pro Cys Xaa 
545                 550                 555                 560 


Met Arg Leu Pro Pro Pro Xaa Xaa Lys Asp Ala Xaa Leu Glu Xaa Val 
                565                 570                 575     


Met Ala Xaa Leu Pro Asn Phe His Gln Ala Ser Leu Gln Met Ser Ile 
            580                 585                 590         


Xaa Trp Gln Leu Gly Arg Arg Gln Pro Val Met Val Ala Val Gly Gln 
        595                 600                 605             


His Glu Glu Glu Tyr Phe Ser Gly Pro Glu Pro Lys Ala Val Leu Lys 
    610                 615                 620                 


Lys Phe Arg Glu Glu Leu Ala Ala Leu Asp Lys Glu Ile Glu Ile Arg 
625                 630                 635                 640 


Asn Ala Lys Leu Asp Met Pro Tyr Glu Tyr Leu Arg Pro Ser Val Val 
                645                 650                 655     


Glu Asn Ser Val Ala Ile 
            660         


<210> 2215
<211> 623
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<400> 2215
Met Gly Leu Tyr Arg Ile Arg Val Ser Xaa Gly Ala Ser Leu Tyr Ala 
1               5                   10                  15      


Gly Ser Asn Asn Gln Val Gln Leu Trp Leu Val Gly Gln His Gly Glu 
            20                  25                  30          


Ala Ala Leu Gly Lys Arg Leu Trp Pro Ala Arg Gly Lys Gly Pro Gly 
        35                  40                  45              


Ala Gly Asp Glu Val Arg Phe Pro Cys Tyr Arg Trp Val Glu Gly Asn 
    50                  55                  60                  


Gly Val Leu Ser Leu Pro Glu Gly Xaa Gly Arg Xaa Val Gly Glu Asp 
65                  70                  75                  80  


Pro Gln Gly Leu Phe Gln Lys His Arg Glu Glu Glu Leu Glu Glu Arg 
                85                  90                  95      


Arg Lys Leu Tyr Arg Trp Gly Asn Trp Lys Asp Gly Leu Ile Leu Asn 
            100                 105                 110         


Met Ala Gly Ala Lys Leu Tyr Asp Leu Pro Val Asp Glu Arg Phe Leu 
        115                 120                 125             


Glu Asp Lys Arg Val Asp Phe Glu Val Ser Leu Ala Lys Gly Leu Ala 
    130                 135                 140                 


Asp Leu Ala Ile Lys Asp Ser Leu Asn Val Leu Xaa Cys Trp Lys Asp 
145                 150                 155                 160 


Leu Asp Asp Phe Asn Arg Ile Phe Trp Cys Gly Gln Ser Lys Leu Ala 
                165                 170                 175     


Glu Arg Val Arg Asp Ser Trp Lys Glu Asp Ala Leu Phe Gly Tyr Gln 
            180                 185                 190         


Phe Leu Asn Gly Ala Asn Pro Val Val Leu Arg Arg Ser Ala His Leu 
        195                 200                 205             


Pro Ala Arg Leu Val Phe Pro Pro Gly Met Glu Glu Leu Gln Ala Gln 
    210                 215                 220                 


Leu Glu Lys Glu Leu Glu Gly Gly Xaa Leu Phe Glu Ala Asp Phe Ser 
225                 230                 235                 240 


Leu Leu Asp Gly Ile Lys Ala Asn Val Ile Leu Cys Ser Gln Gln His 
                245                 250                 255     


Leu Ala Ala Pro Leu Val Met Leu Lys Leu Gln Pro Asp Gly Lys Leu 
            260                 265                 270         


Leu Pro Met Val Ile Gln Leu Gln Leu Pro Arg Xaa Gly Ser Pro Pro 
        275                 280                 285             


Pro Pro Leu Phe Leu Pro Xaa Asp Pro Pro Met Ala Trp Leu Leu Ala 
    290                 295                 300                 


Lys Cys Trp Val Arg Ser Ser Asp Phe Gln Leu His Glu Leu Gln Ser 
305                 310                 315                 320 


His Leu Leu Arg Gly His Leu Met Ala Glu Val Ile Val Val Ala Xaa 
                325                 330                 335     


Met Arg Cys Leu Pro Ser Ile His Pro Ile Phe Lys Leu Ile Ile Pro 
            340                 345                 350         


His Leu Arg Tyr Xaa Leu Glu Ile Asn Val Arg Ala Arg Xaa Gly Leu 
        355                 360                 365             


Val Ser Asp Met Gly Ile Phe Asp Gln Ile Met Ser Xaa Gly Gly Gly 
    370                 375                 380                 


Gly His Val Gln Leu Leu Lys Gln Ala Gly Ala Phe Leu Xaa Tyr Ser 
385                 390                 395                 400 


Ser Phe Cys Pro Pro Asp Asp Leu Ala Asp Arg Gly Leu Leu Gly Val 
                405                 410                 415     


Lys Ser Ser Phe Tyr Ala Gln Asp Ala Leu Arg Leu Trp Glu Ile Ile 
            420                 425                 430         


Tyr Arg Tyr Val Glu Gly Ile Val Ser Leu His Tyr Lys Xaa Asp Val 
        435                 440                 445             


Ala Val Lys Asp Asp Pro Glu Leu Gln Xaa Trp Cys Arg Glu Ile Xaa 
    450                 455                 460                 


Glu Ile Gly Leu Gln Gly Ala Gln Asp Arg Gly Phe Pro Val Ser Leu 
465                 470                 475                 480 


Gln Ala Arg Asp Gln Val Cys His Phe Val Xaa Met Cys Ile Phe Xaa 
                485                 490                 495     


Cys Xaa Gly Gln His Ala Ser Val His Leu Gly Gln Leu Asp Trp Tyr 
            500                 505                 510         


Ser Trp Val Pro Asn Ala Pro Cys Xaa Met Arg Leu Pro Pro Pro Xaa 
        515                 520                 525             


Xaa Lys Asp Ala Xaa Leu Glu Xaa Val Met Ala Xaa Leu Pro Asn Phe 
    530                 535                 540                 


His Gln Ala Ser Leu Gln Met Ser Ile Xaa Trp Gln Leu Gly Arg Arg 
545                 550                 555                 560 


Gln Pro Val Met Val Ala Val Gly Gln His Glu Glu Glu Tyr Phe Ser 
                565                 570                 575     


Gly Pro Glu Pro Lys Ala Val Leu Lys Lys Phe Arg Glu Glu Leu Ala 
            580                 585                 590         


Ala Leu Asp Lys Glu Ile Glu Ile Arg Asn Ala Lys Leu Asp Met Pro 
        595                 600                 605             


Tyr Glu Tyr Leu Arg Pro Ser Val Val Glu Asn Ser Val Ala Ile 
    610                 615                 620             


<210> 2216
<211> 602
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<400> 2216
Met Ala Glu Phe Arg Val Arg Val Ser Xaa Gly Glu Ala Phe Gly Ala 
1               5                   10                  15      


Gly Xaa Trp Asp Lys Val Ser Val Ser Ile Val Gly Xaa Arg Gly Glu 
            20                  25                  30          


Ser Pro Pro Leu Pro Leu Asp Asn Leu Gly Lys Glu Phe Xaa Ala Gly 
        35                  40                  45              


Ala Glu Glu Asp Phe Gln Val Xaa Leu Pro Glu Asp Val Gly Arg Val 
    50                  55                  60                  


Leu Leu Leu Arg Val His Lys Ala Pro Pro Val Leu Pro Leu Leu Gly 
65                  70                  75                  80  


Pro Leu Ala Pro Asp Ala Trp Phe Cys Arg Trp Phe Gln Leu Xaa Pro 
                85                  90                  95      


Pro Arg Gly Gly His Leu Leu Phe Pro Cys Tyr Gln Trp Leu Glu Gly 
            100                 105                 110         


Ala Gly Xaa Leu Val Leu Gln Glu Gly Xaa Ala Lys Val Ser Trp Ala 
        115                 120                 125             


Asp His His Pro Val Leu Gln Gln Gln Arg Gln Glu Glu Leu Gln Ala 
    130                 135                 140                 


Arg Gln Glu Met Tyr Gln Trp Lys Ala Tyr Asn Pro Gly Trp Pro His 
145                 150                 155                 160 


Cys Leu Asp Glu Lys Xaa Val Glu Asp Leu Glu Leu Asn Ile Lys Tyr 
                165                 170                 175     


Ser Xaa Ala Lys Asn Ala Asn Phe Tyr Leu Gln Ala Gly Ser Ala Phe 
            180                 185                 190         


Ala Glu Met Lys Ile Lys Gly Leu Leu Asp Arg Lys Gly Leu Trp Arg 
        195                 200                 205             


Ser Leu Asn Glu Met Lys Arg Ile Phe Asn Phe Arg Arg Xaa Pro Ala 
    210                 215                 220                 


Ala Glu His Ala Phe Glu His Trp Gln Glu Asp Ala Phe Phe Ala Ser 
225                 230                 235                 240 


Gln Phe Leu Asn Gly Leu Asn Pro Val Leu Ile Arg Arg Cys His Tyr 
                245                 250                 255     


Leu Pro Lys Asn Phe Pro Val Xaa Asp Ala Met Val Ala Ser Val Leu 
            260                 265                 270         


Gly Pro Gly Xaa Ser Leu Gln Ala Glu Leu Glu Lys Gly Ser Leu Phe 
        275                 280                 285             


Leu Val Asp His Gly Ile Leu Ser Gly Ile Gln Xaa Asn Val Ile Asn 
    290                 295                 300                 


Gly Lys Pro Gln Phe Ser Ala Ala Pro Met Xaa Leu Leu Tyr Gln Ser 
305                 310                 315                 320 


Pro Gly Cys Gly Pro Leu Leu Pro Leu Ala Ile Gln Leu Ser Gln Xaa 
                325                 330                 335     


Pro Gly Pro Asn Ser Pro Ile Phe Leu Pro Xaa Asp Asp Lys Trp Asp 
            340                 345                 350         


Trp Leu Leu Ala Lys Xaa Trp Val Arg Asn Ala Glu Phe Ser Phe His 
        355                 360                 365             


Glu Ala Leu Xaa His Leu Leu His Ser His Leu Leu Pro Glu Val Phe 
    370                 375                 380                 


Xaa Leu Ala Xaa Leu Arg Gln Leu Pro His Cys His Pro Leu Phe Lys 
385                 390                 395                 400 


Ser Xaa Gly Ile Gly Ile Glu Gly Phe Ser Glu Leu Ile Gln Arg Asn 
                405                 410                 415     


Met Lys Gln Leu Asn Tyr Ser Leu Leu Cys Leu Pro Glu Asp Ile Arg 
            420                 425                 430         


Xaa Arg Gly Val Glu Asp Ile Pro Gly Tyr Tyr Tyr Arg Asp Asp Gly 
        435                 440                 445             


Met Gln Ile Trp Gly Ile Pro Ser Ser Leu Glu Xaa Arg Glu Ala Leu 
    450                 455                 460                 


Val Gln Tyr Val Xaa Met Val Ile Phe Xaa Cys Ser Ala Lys His Ala 
465                 470                 475                 480 


Ala Val Ser Ala Gly Gln Phe Asp Ser Cys Ala Trp Met Pro Asn Leu 
                485                 490                 495     


Pro Pro Ser Met Gln Leu Pro Pro Pro Xaa Ser Lys Gly Leu Ala Xaa 
            500                 505                 510         


Cys Glu Gly Phe Ile Ala Xaa Leu Pro Pro Val Asn Ala Xaa Cys Asp 
        515                 520                 525             


Val Ile Leu Ala Leu Trp Leu Leu Ser Lys Glu Pro Gly Asp Gln Arg 
    530                 535                 540                 


Pro Leu Gly Xaa Tyr Pro Asp Glu His Phe Xaa Glu Glu Ala Pro Arg 
545                 550                 555                 560 


Arg Ser Ile Ala Xaa Phe Gln Ser Arg Leu Ala Gln Ile Ser Arg Gly 
                565                 570                 575     


Ile Gln Glu Arg Asn Gln Gly Leu Val Leu Pro Tyr Xaa Tyr Leu Asp 
            580                 585                 590         


Pro Pro Leu Ile Glu Asn Ser Val Ser Ile 
        595                 600         


<210> 2217
<211> 647
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<400> 2217
Met Ala Glu Phe Arg Val Arg Val Ser Xaa Gly Glu Ala Phe Gly Ala 
1               5                   10                  15      


Gly Xaa Trp Asp Lys Val Ser Val Ser Ile Val Gly Xaa Arg Gly Glu 
            20                  25                  30          


Ser Pro Pro Leu Pro Leu Asp Asn Leu Gly Lys Glu Phe Xaa Ala Gly 
        35                  40                  45              


Ala Glu Glu Asp Phe Gln Val Xaa Leu Pro Glu Asp Val Gly Arg Val 
    50                  55                  60                  


Leu Leu Leu Arg Val His Lys Ala Pro Pro Val Leu Pro Leu Leu Gly 
65                  70                  75                  80  


Pro Leu Ala Pro Asp Ala Trp Phe Cys Arg Trp Phe Gln Leu Xaa Pro 
                85                  90                  95      


Pro Arg Gly Gly His Leu Leu Phe Pro Cys Tyr Gln Trp Leu Glu Gly 
            100                 105                 110         


Ala Gly Xaa Leu Val Leu Gln Glu Gly Xaa Ala Lys Val Ser Trp Ala 
        115                 120                 125             


Asp His His Pro Val Leu Gln Gln Gln Arg Gln Glu Glu Leu Gln Ala 
    130                 135                 140                 


Arg Gln Glu Met Tyr Gln Trp Lys Ala Tyr Asn Pro Gly Trp Pro His 
145                 150                 155                 160 


Cys Leu Asp Glu Lys Xaa Val Glu Asp Leu Glu Leu Asn Ile Lys Tyr 
                165                 170                 175     


Ser Xaa Ala Lys Asn Ala Asn Phe Tyr Leu Gln Ala Gly Ser Ala Phe 
            180                 185                 190         


Ala Glu Met Lys Ile Lys Gly Leu Leu Asp Arg Lys Gly Leu Trp Arg 
        195                 200                 205             


Ser Leu Asn Glu Met Lys Arg Ile Phe Asn Phe Arg Arg Xaa Pro Ala 
    210                 215                 220                 


Ala Glu His Ala Phe Glu His Trp Gln Glu Asp Ala Phe Phe Ala Ser 
225                 230                 235                 240 


Gln Phe Leu Asn Gly Leu Asn Pro Val Leu Ile Arg Arg Cys His Tyr 
                245                 250                 255     


Leu Pro Lys Asn Phe Pro Val Xaa Asp Ala Met Val Ala Ser Val Leu 
            260                 265                 270         


Gly Pro Gly Xaa Ser Leu Gln Ala Glu Leu Glu Lys Gly Ser Leu Phe 
        275                 280                 285             


Leu Val Asp His Gly Ile Leu Ser Gly Ile Gln Xaa Asn Val Ile Asn 
    290                 295                 300                 


Gly Lys Pro Gln Phe Ser Ala Ala Pro Met Xaa Leu Leu Tyr Gln Ser 
305                 310                 315                 320 


Pro Gly Cys Gly Pro Leu Leu Pro Leu Ala Ile Gln Leu Ser Gln Xaa 
                325                 330                 335     


Pro Gly Pro Asn Ser Pro Ile Phe Leu Pro Xaa Asp Asp Lys Trp Asp 
            340                 345                 350         


Trp Leu Leu Ala Lys Xaa Trp Val Arg Asn Ala Glu Phe Ser Phe His 
        355                 360                 365             


Glu Ala Leu Xaa His Leu Leu His Ser His Leu Leu Pro Glu Val Phe 
    370                 375                 380                 


Xaa Leu Ala Xaa Leu Arg Gln Leu Pro His Cys His Pro Leu Phe Lys 
385                 390                 395                 400 


Ser Xaa Gly Ile Gly Ile Glu Gly Phe Ser Glu Leu Ile Gln Arg Asn 
                405                 410                 415     


Met Lys Gln Leu Asn Tyr Ser Leu Leu Cys Leu Pro Glu Asp Ile Arg 
            420                 425                 430         


Xaa Arg Gly Val Glu Asp Ile Pro Gly Tyr Tyr Tyr Arg Asp Asp Gly 
        435                 440                 445             


Met Gln Ile Trp Gly Ala Val Glu Arg Phe Val Ser Glu Ile Ile Gly 
    450                 455                 460                 


Ile Tyr Tyr Pro Ser Asp Glu Ser Val Gln Asp Asp Arg Glu Leu Gln 
465                 470                 475                 480 


Ala Trp Val Arg Glu Ile Phe Ser Lys Gly Phe Leu Asn Gln Glu Ser 
                485                 490                 495     


Ser Gly Ile Pro Ser Ser Leu Glu Xaa Arg Glu Ala Leu Val Gln Tyr 
            500                 505                 510         


Val Xaa Met Val Ile Phe Xaa Cys Ser Ala Lys His Ala Ala Val Ser 
        515                 520                 525             


Ala Gly Gln Phe Asp Ser Cys Ala Trp Met Pro Asn Leu Pro Pro Ser 
    530                 535                 540                 


Met Gln Leu Pro Pro Pro Xaa Ser Lys Gly Leu Ala Xaa Cys Glu Gly 
545                 550                 555                 560 


Phe Ile Ala Xaa Leu Pro Pro Val Asn Ala Xaa Cys Asp Val Ile Leu 
                565                 570                 575     


Ala Leu Trp Leu Leu Ser Lys Glu Pro Gly Asp Gln Arg Pro Leu Gly 
            580                 585                 590         


Xaa Tyr Pro Asp Glu His Phe Xaa Glu Glu Ala Pro Arg Arg Ser Ile 
        595                 600                 605             


Ala Xaa Phe Gln Ser Arg Leu Ala Gln Ile Ser Arg Gly Ile Gln Glu 
    610                 615                 620                 


Arg Asn Gln Gly Leu Val Leu Pro Tyr Xaa Tyr Leu Asp Pro Pro Leu 
625                 630                 635                 640 


Ile Glu Asn Ser Val Ser Ile 
                645         


<210> 2218
<211> 664
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<400> 2218
Met Ala Glu Phe Arg Val Arg Val Ser Xaa Gly Glu Ala Phe Gly Ala 
1               5                   10                  15      


Gly Xaa Trp Asp Lys Val Ser Val Ser Ile Val Gly Xaa Arg Gly Glu 
            20                  25                  30          


Ser Pro Pro Leu Pro Leu Asp Asn Leu Gly Lys Glu Phe Xaa Ala Gly 
        35                  40                  45              


Ala Glu Glu Asp Phe Gln Val Xaa Leu Pro Glu Asp Val Gly Arg Val 
    50                  55                  60                  


Leu Leu Leu Arg Val His Lys Ala Pro Pro Val Leu Pro Leu Leu Gly 
65                  70                  75                  80  


Pro Leu Ala Pro Asp Ala Trp Phe Cys Arg Trp Phe Gln Leu Xaa Pro 
                85                  90                  95      


Pro Arg Gly Gly His Leu Leu Phe Pro Cys Tyr Gln Trp Leu Glu Gly 
            100                 105                 110         


Ala Gly Xaa Leu Val Leu Gln Glu Gly Xaa Ala Lys Val Ser Trp Ala 
        115                 120                 125             


Asp His His Pro Val Leu Gln Gln Gln Arg Gln Glu Glu Leu Gln Ala 
    130                 135                 140                 


Arg Gln Glu Met Tyr Gln Trp Lys Ala Tyr Asn Pro Gly Trp Pro His 
145                 150                 155                 160 


Cys Leu Asp Glu Lys Xaa Val Glu Asp Leu Glu Leu Asn Ile Lys Tyr 
                165                 170                 175     


Ser Xaa Ala Lys Asn Ala Asn Phe Tyr Leu Gln Ala Gly Ser Ala Phe 
            180                 185                 190         


Ala Glu Met Lys Ile Lys Gly Leu Leu Asp Arg Lys Gly Leu Trp Arg 
        195                 200                 205             


Ser Leu Asn Glu Met Lys Arg Ile Phe Asn Phe Arg Arg Xaa Pro Ala 
    210                 215                 220                 


Ala Glu His Ala Phe Glu His Trp Gln Glu Asp Ala Phe Phe Ala Ser 
225                 230                 235                 240 


Gln Phe Leu Asn Gly Leu Asn Pro Val Leu Ile Arg Arg Cys His Tyr 
                245                 250                 255     


Leu Pro Lys Asn Phe Pro Val Xaa Asp Ala Met Val Ala Ser Val Leu 
            260                 265                 270         


Gly Pro Gly Xaa Ser Leu Gln Ala Glu Leu Glu Lys Gly Ser Leu Phe 
        275                 280                 285             


Leu Val Asp His Gly Ile Leu Ser Gly Ile Gln Xaa Asn Val Ile Asn 
    290                 295                 300                 


Gly Lys Pro Gln Phe Ser Ala Ala Pro Met Xaa Leu Leu Tyr Gln Ser 
305                 310                 315                 320 


Pro Gly Cys Gly Pro Leu Leu Pro Leu Ala Ile Gln Leu Ser Gln Xaa 
                325                 330                 335     


Pro Gly Pro Asn Ser Pro Ile Phe Leu Pro Xaa Asp Asp Lys Trp Asp 
            340                 345                 350         


Trp Leu Leu Ala Lys Xaa Trp Val Arg Asn Ala Glu Phe Ser Phe His 
        355                 360                 365             


Glu Ala Leu Xaa His Leu Leu His Ser His Leu Leu Pro Glu Val Phe 
    370                 375                 380                 


Xaa Leu Ala Xaa Leu Arg Gln Leu Pro His Cys His Pro Leu Phe Lys 
385                 390                 395                 400 


Leu Leu Ile Pro His Xaa Arg Tyr Xaa Leu His Ile Asn Xaa Leu Ala 
                405                 410                 415     


Arg Glu Leu Leu Ile Val Pro Gly Gln Val Val Asp Arg Ser Xaa Gly 
            420                 425                 430         


Ile Gly Ile Glu Gly Phe Ser Glu Leu Ile Gln Arg Asn Met Lys Gln 
        435                 440                 445             


Leu Asn Tyr Ser Leu Leu Cys Leu Pro Glu Asp Ile Arg Xaa Arg Gly 
    450                 455                 460                 


Val Glu Asp Ile Pro Gly Tyr Tyr Tyr Arg Asp Asp Gly Met Gln Ile 
465                 470                 475                 480 


Trp Gly Ala Val Glu Arg Asp Glu Ser Val Gln Asp Asp Arg Glu Leu 
                485                 490                 495     


Gln Ala Trp Val Arg Glu Ile Phe Ser Lys Gly Phe Leu Asn Gln Glu 
            500                 505                 510         


Ser Ser Gly Ile Pro Ser Ser Leu Glu Xaa Arg Glu Ala Leu Val Gln 
        515                 520                 525             


Tyr Val Xaa Met Val Ile Phe Xaa Cys Ser Ala Lys His Ala Ala Val 
    530                 535                 540                 


Ser Ala Gly Gln Phe Asp Ser Cys Ala Trp Met Pro Asn Leu Pro Pro 
545                 550                 555                 560 


Ser Met Gln Leu Pro Pro Pro Xaa Ser Lys Gly Leu Ala Xaa Cys Glu 
                565                 570                 575     


Gly Phe Ile Ala Xaa Leu Pro Pro Val Asn Ala Xaa Cys Asp Val Ile 
            580                 585                 590         


Leu Ala Leu Trp Leu Leu Ser Lys Glu Pro Gly Asp Gln Arg Pro Leu 
        595                 600                 605             


Gly Xaa Tyr Pro Asp Glu His Phe Xaa Glu Glu Ala Pro Arg Arg Ser 
    610                 615                 620                 


Ile Ala Xaa Phe Gln Ser Arg Leu Ala Gln Ile Ser Arg Gly Ile Gln 
625                 630                 635                 640 


Glu Arg Asn Gln Gly Leu Val Leu Pro Tyr Xaa Tyr Leu Asp Pro Pro 
                645                 650                 655     


Leu Ile Glu Asn Ser Val Ser Ile 
            660                 


<210> 2219
<211> 676
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<400> 2219
Met Ala Glu Phe Arg Val Arg Val Ser Xaa Gly Glu Ala Phe Gly Ala 
1               5                   10                  15      


Gly Xaa Trp Asp Lys Val Ser Val Ser Ile Val Gly Xaa Arg Gly Glu 
            20                  25                  30          


Ser Pro Pro Leu Pro Leu Asp Asn Leu Gly Lys Glu Phe Xaa Ala Gly 
        35                  40                  45              


Ala Glu Glu Asp Phe Gln Val Xaa Leu Pro Glu Asp Val Gly Arg Val 
    50                  55                  60                  


Leu Leu Leu Arg Val His Lys Ala Pro Pro Val Leu Pro Leu Leu Gly 
65                  70                  75                  80  


Pro Leu Ala Pro Asp Ala Trp Phe Cys Arg Trp Phe Gln Leu Xaa Pro 
                85                  90                  95      


Pro Arg Gly Gly His Leu Leu Phe Pro Cys Tyr Gln Trp Leu Glu Gly 
            100                 105                 110         


Ala Gly Xaa Leu Val Leu Gln Glu Gly Xaa Ala Lys Val Ser Trp Ala 
        115                 120                 125             


Asp His His Pro Val Leu Gln Gln Gln Arg Gln Glu Glu Leu Gln Ala 
    130                 135                 140                 


Arg Gln Glu Met Tyr Gln Trp Lys Ala Tyr Asn Pro Gly Trp Pro His 
145                 150                 155                 160 


Cys Leu Asp Glu Lys Xaa Val Glu Asp Leu Glu Leu Asn Ile Lys Tyr 
                165                 170                 175     


Ser Xaa Ala Lys Asn Ala Asn Phe Tyr Leu Gln Ala Gly Ser Ala Phe 
            180                 185                 190         


Ala Glu Met Lys Ile Lys Gly Leu Leu Asp Arg Lys Gly Leu Trp Arg 
        195                 200                 205             


Ser Leu Asn Glu Met Lys Arg Ile Phe Asn Phe Arg Arg Xaa Pro Ala 
    210                 215                 220                 


Ala Glu His Ala Phe Glu His Trp Gln Glu Asp Ala Phe Phe Ala Ser 
225                 230                 235                 240 


Gln Phe Leu Asn Gly Leu Asn Pro Val Leu Ile Arg Arg Cys His Tyr 
                245                 250                 255     


Leu Pro Lys Asn Phe Pro Val Xaa Asp Ala Met Val Ala Ser Val Leu 
            260                 265                 270         


Gly Pro Gly Xaa Ser Leu Gln Ala Glu Leu Glu Lys Gly Ser Leu Phe 
        275                 280                 285             


Leu Val Asp His Gly Ile Leu Ser Gly Ile Gln Xaa Asn Val Ile Asn 
    290                 295                 300                 


Gly Lys Pro Gln Phe Ser Ala Ala Pro Met Xaa Leu Leu Tyr Gln Ser 
305                 310                 315                 320 


Pro Gly Cys Gly Pro Leu Leu Pro Leu Ala Ile Gln Leu Ser Gln Xaa 
                325                 330                 335     


Pro Gly Pro Asn Ser Pro Ile Phe Leu Pro Xaa Asp Asp Lys Trp Asp 
            340                 345                 350         


Trp Leu Leu Ala Lys Xaa Trp Val Arg Asn Ala Glu Phe Ser Phe His 
        355                 360                 365             


Glu Ala Leu Xaa His Leu Leu His Ser His Leu Leu Pro Glu Val Phe 
    370                 375                 380                 


Xaa Leu Ala Xaa Leu Arg Gln Leu Pro His Cys His Pro Leu Phe Lys 
385                 390                 395                 400 


Leu Leu Ile Pro His Xaa Arg Tyr Xaa Leu His Ile Asn Xaa Leu Ala 
                405                 410                 415     


Arg Glu Leu Leu Ile Val Pro Gly Gln Val Val Asp Arg Ser Xaa Gly 
            420                 425                 430         


Ile Gly Ile Glu Gly Phe Ser Glu Leu Ile Gln Arg Asn Met Lys Gln 
        435                 440                 445             


Leu Asn Tyr Ser Leu Leu Cys Leu Pro Glu Asp Ile Arg Xaa Arg Gly 
    450                 455                 460                 


Val Glu Asp Ile Pro Gly Tyr Tyr Tyr Arg Asp Asp Gly Met Gln Ile 
465                 470                 475                 480 


Trp Gly Ala Val Glu Arg Phe Val Ser Glu Ile Ile Gly Ile Tyr Tyr 
                485                 490                 495     


Pro Ser Asp Glu Ser Val Gln Asp Asp Arg Glu Leu Gln Ala Trp Val 
            500                 505                 510         


Arg Glu Ile Phe Ser Lys Gly Phe Leu Asn Gln Glu Ser Ser Gly Ile 
        515                 520                 525             


Pro Ser Ser Leu Glu Xaa Arg Glu Ala Leu Val Gln Tyr Val Xaa Met 
    530                 535                 540                 


Val Ile Phe Xaa Cys Ser Ala Lys His Ala Ala Val Ser Ala Gly Gln 
545                 550                 555                 560 


Phe Asp Ser Cys Ala Trp Met Pro Asn Leu Pro Pro Ser Met Gln Leu 
                565                 570                 575     


Pro Pro Pro Xaa Ser Lys Gly Leu Ala Xaa Cys Glu Gly Phe Ile Ala 
            580                 585                 590         


Xaa Leu Pro Pro Val Asn Ala Xaa Cys Asp Val Ile Leu Ala Leu Trp 
        595                 600                 605             


Leu Leu Ser Lys Glu Pro Gly Asp Gln Arg Pro Leu Gly Xaa Tyr Pro 
    610                 615                 620                 


Asp Glu His Phe Xaa Glu Glu Ala Pro Arg Arg Ser Ile Ala Xaa Phe 
625                 630                 635                 640 


Gln Ser Arg Leu Ala Gln Ile Ser Arg Gly Ile Gln Glu Arg Asn Gln 
                645                 650                 655     


Gly Leu Val Leu Pro Tyr Xaa Tyr Leu Asp Pro Pro Leu Ile Glu Asn 
            660                 665                 670         


Ser Val Ser Ile 
        675     


<210> 2220
<211> 711
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<400> 2220
Met Ala Val Tyr Arg Leu Cys Val Xaa Xaa Gly Pro Tyr Leu Arg Ala 
1               5                   10                  15      


Gly Xaa Leu Asp Asn Ile Ser Val Xaa Leu Val Gly Xaa Cys Gly Glu 
            20                  25                  30          


Ser Pro Lys Gln Arg Leu Asp Arg Met Gly Arg Asp Phe Ala Pro Gly 
        35                  40                  45              


Ser Val Gln Lys Tyr Lys Val Arg Cys Xaa Ala Glu Leu Gly Glu Leu 
    50                  55                  60                  


Leu Leu Leu Arg Val His Lys Glu Arg Tyr Ala Phe Phe Arg Lys Asp 
65                  70                  75                  80  


Ser Trp Tyr Cys Ser Arg Ile Cys Val Xaa Glu Pro Asp Gly Ser Val 
                85                  90                  95      


Ser His Phe Pro Cys Tyr Gln Trp Ile Glu Gly Tyr Cys Xaa Val Glu 
            100                 105                 110         


Leu Arg Pro Gly Xaa Ala Arg Xaa Ile Cys Gln Asp Ser Leu Pro Leu 
        115                 120                 125             


Leu Leu Asp His Arg Xaa Arg Glu Leu Arg Ala Arg Gln Glu Cys Tyr 
    130                 135                 140                 


Arg Trp Lys Ile Tyr Ala Pro Gly Phe Pro Cys Met Val Asp Val Asn 
145                 150                 155                 160 


Ser Phe Gln Glu Met Glu Ser Asp Lys Lys Phe Ala Leu Xaa Lys Xaa 
                165                 170                 175     


Xaa Xaa Cys Val Asp Gln Gly Asp Ser Ser Gly Asn Arg Tyr Leu Pro 
            180                 185                 190         


Gly Phe Pro Met Lys Ile Asp Ile Pro Ser Leu Met Tyr Met Glu Pro 
        195                 200                 205             


Asn Val Arg Tyr Ser Ala Xaa Lys Xaa Ile Ser Leu Leu Phe Asn Ala 
    210                 215                 220                 


Ile Pro Ala Ser Leu Gly Met Lys Leu Arg Gly Leu Leu Asp Arg Lys 
225                 230                 235                 240 


Gly Ser Trp Lys Lys Leu Asp Asp Met Gln Asn Ile Phe Trp Cys His 
                245                 250                 255     


Lys Xaa Phe Xaa Xaa Lys Tyr Val Xaa Glu His Trp Cys Glu Asp His 
            260                 265                 270         


Phe Phe Gly Tyr Gln Tyr Leu Asn Gly Val Asn Pro Val Met Leu His 
        275                 280                 285             


Cys Ile Ser Ser Leu Pro Ser Lys Leu Pro Val Xaa Asn Asp Met Val 
    290                 295                 300                 


Ala Pro Leu Leu Gly Gln Asp Xaa Cys Leu Gln Xaa Glu Leu Glu Arg 
305                 310                 315                 320 


Gly Asn Ile Phe Leu Ala Asp Tyr Trp Ile Leu Ala Glu Ala Pro Xaa 
                325                 330                 335     


His Cys Leu Asn Gly Arg Gln Gln Tyr Val Ala Ala Pro Leu Cys Leu 
            340                 345                 350         


Leu Trp Leu Ser Pro Gln Gly Ala Leu Val Pro Leu Ala Ile Gln Leu 
        355                 360                 365             


Ser Gln Xaa Pro Gly Pro Asp Ser Pro Ile Phe Leu Pro Xaa Asp Ser 
    370                 375                 380                 


Glu Trp Asp Trp Leu Leu Ala Lys Xaa Trp Val Arg Asn Ser Glu Phe 
385                 390                 395                 400 


Leu Val His Glu Asn Asn Xaa His Phe Leu Cys Xaa His Leu Leu Cys 
                405                 410                 415     


Glu Ala Phe Ala Met Ala Xaa Leu Arg Gln Leu Pro Leu Cys His Pro 
            420                 425                 430         


Ile Tyr Lys Leu Leu Leu Pro His Xaa Arg Tyr Xaa Leu Gln Val Asn 
        435                 440                 445             


Xaa Ile Ala Arg Ala Xaa Leu Leu Asn Pro Glu Gly Leu Val Asp Gln 
    450                 455                 460                 


Val Xaa Ser Ile Gly Arg Gln Gly Leu Ile Tyr Leu Met Ser Xaa Gly 
465                 470                 475                 480 


Leu Ala His Phe Xaa Tyr Xaa Asn Phe Cys Leu Pro Asp Ser Leu Arg 
                485                 490                 495     


Ala Arg Gly Val Leu Ala Ile Pro Asn Tyr His Tyr Arg Asp Asp Gly 
            500                 505                 510         


Leu Lys Ile Trp Ala Ala Ile Glu Ser Phe Val Ser Glu Ile Val Gly 
        515                 520                 525             


Tyr Tyr Tyr Pro Ser Asp Ala Ser Val Gln Gln Asp Ser Glu Leu Gln 
    530                 535                 540                 


Ala Trp Xaa Gly Glu Ile Phe Ala Gln Ala Phe Leu Gly Arg Glu Ser 
545                 550                 555                 560 


Ser Gly Phe Pro Ser Arg Leu Cys Xaa Pro Gly Glu Met Val Lys Phe 
                565                 570                 575     


Leu Xaa Ala Ile Ile Phe Asn Cys Ser Ala Gln His Ala Ala Val Asn 
            580                 585                 590         


Ser Gly Gln His Asp Phe Gly Ala Trp Met Pro Asn Ala Pro Ser Ser 
        595                 600                 605             


Met Arg Gln Pro Pro Pro Gln Xaa Lys Gly Xaa Xaa Xaa Leu Lys Xaa 
    610                 615                 620                 


Tyr Leu Asp Xaa Leu Pro Glu Val Asn Ile Ser Cys Asn Asn Leu Leu 
625                 630                 635                 640 


Leu Phe Trp Leu Val Ser Gln Glu Pro Lys Asp Gln Arg Pro Leu Gly 
                645                 650                 655     


Xaa Tyr Pro Asp Glu His Phe Xaa Glu Glu Ala Pro Arg Arg Ser Ile 
            660                 665                 670         


Ala Ala Phe Gln Ser Arg Leu Ala Gln Ile Ser Arg Asp Ile Gln Glu 
        675                 680                 685             


Arg Asn Gln Gly Leu Ala Leu Pro Tyr Xaa Tyr Leu Asp Pro Pro Leu 
    690                 695                 700                 


Ile Glu Asn Ser Val Ser Ile 
705                 710     


<210> 2221
<211> 867
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<400> 2221
Met Gly Arg Asn Arg Ser Trp Gly Xaa Leu Gly Ser Gly Arg Xaa Ser 
1               5                   10                  15      


Xaa Pro Gly His Gln Ser Gly Pro Leu Xaa Arg Arg Arg Ala Val Ser 
            20                  25                  30          


Gln Leu Tyr Arg Arg Tyr Leu Leu Phe Ser Ile Ser Ala Ser Asp Pro 
        35                  40                  45              


Ser Leu Arg Ser Gly Xaa Gln Ala Pro Asp Ile His Leu Gly Glu Pro 
    50                  55                  60                  


Ala Arg Gly Xaa Gly Cys Val Arg Gly Lys Gln Xaa Ser Ile Arg Val 
65                  70                  75                  80  


Gln Asp Cys Gly Arg Arg Glu Glu Ala Arg Ala Ala Ser Arg Glu Leu 
                85                  90                  95      


Arg Arg Glu Lys Ala Gln Glu His Pro Arg Glu Ser Trp Ala His Pro 
            100                 105                 110         


Gln Pro Tyr Pro Ala Pro Gln Pro Leu Ala Leu Arg Pro Glu Xaa Gln 
        115                 120                 125             


Pro Cys Pro Ala Cys Arg Ser Ser Pro Pro Gly Arg Leu Leu Leu Arg 
    130                 135                 140                 


Pro Ala Leu Pro Gly His Pro Phe Leu Leu Pro Ile Met Ala Val Tyr 
145                 150                 155                 160 


Arg Leu Cys Val Xaa Xaa Gly Pro Tyr Leu Arg Ala Gly Xaa Leu Asp 
                165                 170                 175     


Asn Ile Ser Val Xaa Leu Val Gly Xaa Cys Gly Glu Ser Pro Lys Gln 
            180                 185                 190         


Arg Leu Asp Arg Met Gly Arg Asp Phe Ala Pro Gly Ser Val Gln Lys 
        195                 200                 205             


Tyr Lys Val Arg Cys Xaa Ala Glu Leu Gly Glu Leu Leu Leu Leu Arg 
    210                 215                 220                 


Val His Lys Glu Arg Tyr Ala Phe Phe Arg Lys Asp Ser Trp Tyr Cys 
225                 230                 235                 240 


Ser Arg Ile Cys Val Xaa Glu Pro Asp Gly Ser Val Ser His Phe Pro 
                245                 250                 255     


Cys Tyr Gln Trp Ile Glu Gly Tyr Cys Xaa Val Glu Leu Arg Pro Gly 
            260                 265                 270         


Xaa Ala Arg Xaa Ile Cys Gln Asp Ser Leu Pro Leu Leu Leu Asp His 
        275                 280                 285             


Arg Xaa Arg Glu Leu Arg Ala Arg Gln Glu Cys Tyr Arg Trp Lys Ile 
    290                 295                 300                 


Tyr Ala Pro Gly Phe Pro Cys Met Val Asp Val Asn Ser Phe Gln Glu 
305                 310                 315                 320 


Met Glu Ser Asp Lys Lys Phe Ala Leu Xaa Lys Xaa Xaa Xaa Cys Val 
                325                 330                 335     


Asp Gln Gly Asp Ser Ser Gly Asn Arg Tyr Leu Pro Gly Phe Pro Met 
            340                 345                 350         


Lys Ile Asp Ile Pro Ser Leu Met Tyr Met Glu Pro Asn Val Arg Tyr 
        355                 360                 365             


Ser Ala Xaa Lys Xaa Ile Ser Leu Leu Phe Asn Ala Ile Pro Ala Ser 
    370                 375                 380                 


Leu Gly Met Lys Leu Arg Gly Leu Leu Asp Arg Lys Gly Ser Trp Lys 
385                 390                 395                 400 


Lys Leu Asp Asp Met Gln Asn Ile Phe Trp Cys His Lys Xaa Phe Xaa 
                405                 410                 415     


Xaa Lys Tyr Val Xaa Glu His Trp Cys Glu Asp His Phe Phe Gly Tyr 
            420                 425                 430         


Gln Tyr Leu Asn Gly Val Asn Pro Val Met Leu His Cys Ile Ser Ser 
        435                 440                 445             


Leu Pro Ser Lys Leu Pro Val Xaa Asn Asp Met Val Ala Pro Leu Leu 
    450                 455                 460                 


Gly Gln Asp Xaa Cys Leu Gln Xaa Glu Leu Glu Arg Gly Asn Ile Phe 
465                 470                 475                 480 


Leu Ala Asp Tyr Trp Ile Leu Ala Glu Ala Pro Xaa His Cys Leu Asn 
                485                 490                 495     


Gly Arg Gln Gln Tyr Val Ala Ala Pro Leu Cys Leu Leu Trp Leu Ser 
            500                 505                 510         


Pro Gln Gly Ala Leu Val Pro Leu Ala Ile Gln Leu Ser Gln Xaa Pro 
        515                 520                 525             


Gly Pro Asp Ser Pro Ile Phe Leu Pro Xaa Asp Ser Glu Trp Asp Trp 
    530                 535                 540                 


Leu Leu Ala Lys Xaa Trp Val Arg Asn Ser Glu Phe Leu Val His Glu 
545                 550                 555                 560 


Asn Asn Xaa His Phe Leu Cys Xaa His Leu Leu Cys Glu Ala Phe Ala 
                565                 570                 575     


Met Ala Xaa Leu Arg Gln Leu Pro Leu Cys His Pro Ile Tyr Lys Leu 
            580                 585                 590         


Leu Leu Pro His Xaa Arg Tyr Xaa Leu Gln Val Asn Xaa Ile Ala Arg 
        595                 600                 605             


Ala Xaa Leu Leu Asn Pro Glu Gly Leu Val Asp Gln Val Xaa Ser Ile 
    610                 615                 620                 


Gly Arg Gln Gly Leu Ile Tyr Leu Met Ser Xaa Gly Leu Ala His Phe 
625                 630                 635                 640 


Xaa Tyr Xaa Asn Phe Cys Leu Pro Asp Ser Leu Arg Ala Arg Gly Val 
                645                 650                 655     


Leu Ala Ile Pro Asn Tyr His Tyr Arg Asp Asp Gly Leu Lys Ile Trp 
            660                 665                 670         


Ala Ala Ile Glu Ser Phe Val Ser Glu Ile Val Gly Tyr Tyr Tyr Pro 
        675                 680                 685             


Ser Asp Ala Ser Val Gln Gln Asp Ser Glu Leu Gln Ala Trp Xaa Gly 
    690                 695                 700                 


Glu Ile Phe Ala Gln Ala Phe Leu Gly Arg Glu Ser Ser Gly Phe Pro 
705                 710                 715                 720 


Ser Arg Leu Cys Xaa Pro Gly Glu Met Val Lys Phe Leu Xaa Ala Ile 
                725                 730                 735     


Ile Phe Asn Cys Ser Ala Gln His Ala Ala Val Asn Ser Gly Gln His 
            740                 745                 750         


Asp Phe Gly Ala Trp Met Pro Asn Ala Pro Ser Ser Met Arg Gln Pro 
        755                 760                 765             


Pro Pro Gln Xaa Lys Gly Xaa Xaa Xaa Leu Lys Xaa Tyr Leu Asp Xaa 
    770                 775                 780                 


Leu Pro Glu Val Asn Ile Ser Cys Asn Asn Leu Leu Leu Phe Trp Leu 
785                 790                 795                 800 


Val Ser Gln Glu Pro Lys Asp Gln Arg Pro Leu Gly Xaa Tyr Pro Asp 
                805                 810                 815     


Glu His Phe Xaa Glu Glu Ala Pro Arg Arg Ser Ile Ala Ala Phe Gln 
            820                 825                 830         


Ser Arg Leu Ala Gln Ile Ser Arg Asp Ile Gln Glu Arg Asn Gln Gly 
        835                 840                 845             


Leu Ala Leu Pro Tyr Xaa Tyr Leu Asp Pro Pro Leu Ile Glu Asn Ser 
    850                 855                 860                 


Val Ser Ile 
865         


<210> 2222
<211> 843
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<400> 2222
Met Pro Arg Gly Ala Phe Arg Pro Cys Leu Pro Ala Leu Tyr Phe Ala 
1               5                   10                  15      


Phe Leu Xaa Cys Pro Xaa Pro Glu Gln Arg Met Ser Gly Xaa Gln Ala 
            20                  25                  30          


Pro Asp Ile His Leu Gly Glu Pro Ala Arg Gly Xaa Gly Cys Val Arg 
        35                  40                  45              


Gly Lys Gln Xaa Ser Ile Arg Val Gln Asp Cys Gly Arg Arg Glu Glu 
    50                  55                  60                  


Ala Arg Ala Ala Ser Arg Glu Leu Arg Arg Glu Lys Ala Gln Glu His 
65                  70                  75                  80  


Pro Arg Glu Ser Trp Ala His Pro Gln Pro Tyr Pro Ala Pro Gln Pro 
                85                  90                  95      


Leu Ala Leu Arg Pro Glu Xaa Gln Pro Cys Pro Ala Cys Arg Ser Ser 
            100                 105                 110         


Pro Pro Gly Arg Leu Leu Leu Arg Pro Ala Leu Pro Gly His Pro Phe 
        115                 120                 125             


Leu Leu Pro Ile Met Ala Val Tyr Arg Leu Cys Val Xaa Xaa Gly Pro 
    130                 135                 140                 


Tyr Leu Arg Ala Gly Xaa Leu Asp Asn Ile Ser Val Xaa Leu Val Gly 
145                 150                 155                 160 


Xaa Cys Gly Glu Ser Pro Lys Gln Arg Leu Asp Arg Met Gly Arg Asp 
                165                 170                 175     


Phe Ala Pro Gly Ser Val Gln Lys Tyr Lys Val Arg Cys Xaa Ala Glu 
            180                 185                 190         


Leu Gly Glu Leu Leu Leu Leu Arg Val His Lys Glu Arg Tyr Ala Phe 
        195                 200                 205             


Phe Arg Lys Asp Ser Trp Tyr Cys Ser Arg Ile Cys Val Xaa Glu Pro 
    210                 215                 220                 


Asp Gly Ser Val Ser His Phe Pro Cys Tyr Gln Trp Ile Glu Gly Tyr 
225                 230                 235                 240 


Cys Xaa Val Glu Leu Arg Pro Gly Xaa Ala Arg Xaa Ile Cys Gln Asp 
                245                 250                 255     


Ser Leu Pro Leu Leu Leu Asp His Arg Xaa Arg Glu Leu Arg Ala Arg 
            260                 265                 270         


Gln Glu Cys Tyr Arg Trp Lys Ile Tyr Ala Pro Gly Phe Pro Cys Met 
        275                 280                 285             


Val Asp Val Asn Ser Phe Gln Glu Met Glu Ser Asp Lys Lys Phe Ala 
    290                 295                 300                 


Leu Xaa Lys Xaa Xaa Xaa Cys Val Asp Gln Gly Asp Ser Ser Gly Asn 
305                 310                 315                 320 


Arg Tyr Leu Pro Gly Phe Pro Met Lys Ile Asp Ile Pro Ser Leu Met 
                325                 330                 335     


Tyr Met Glu Pro Asn Val Arg Tyr Ser Ala Xaa Lys Xaa Ile Ser Leu 
            340                 345                 350         


Leu Phe Asn Ala Ile Pro Ala Ser Leu Gly Met Lys Leu Arg Gly Leu 
        355                 360                 365             


Leu Asp Arg Lys Gly Ser Trp Lys Lys Leu Asp Asp Met Gln Asn Ile 
    370                 375                 380                 


Phe Trp Cys His Lys Xaa Phe Xaa Xaa Lys Tyr Val Xaa Glu His Trp 
385                 390                 395                 400 


Cys Glu Asp His Phe Phe Gly Tyr Gln Tyr Leu Asn Gly Val Asn Pro 
                405                 410                 415     


Val Met Leu His Cys Ile Ser Ser Leu Pro Ser Lys Leu Pro Val Xaa 
            420                 425                 430         


Asn Asp Met Val Ala Pro Leu Leu Gly Gln Asp Xaa Cys Leu Gln Xaa 
        435                 440                 445             


Glu Leu Glu Arg Gly Asn Ile Phe Leu Ala Asp Tyr Trp Ile Leu Ala 
    450                 455                 460                 


Glu Ala Pro Xaa His Cys Leu Asn Gly Arg Gln Gln Tyr Val Ala Ala 
465                 470                 475                 480 


Pro Leu Cys Leu Leu Trp Leu Ser Pro Gln Gly Ala Leu Val Pro Leu 
                485                 490                 495     


Ala Ile Gln Leu Ser Gln Xaa Pro Gly Pro Asp Ser Pro Ile Phe Leu 
            500                 505                 510         


Pro Xaa Asp Ser Glu Trp Asp Trp Leu Leu Ala Lys Xaa Trp Val Arg 
        515                 520                 525             


Asn Ser Glu Phe Leu Val His Glu Asn Asn Xaa His Phe Leu Cys Xaa 
    530                 535                 540                 


His Leu Leu Cys Glu Ala Phe Ala Met Ala Xaa Leu Arg Gln Leu Pro 
545                 550                 555                 560 


Leu Cys His Pro Ile Tyr Lys Leu Leu Leu Pro His Xaa Arg Tyr Xaa 
                565                 570                 575     


Leu Gln Val Asn Xaa Ile Ala Arg Ala Xaa Leu Leu Asn Pro Glu Gly 
            580                 585                 590         


Leu Val Asp Gln Val Xaa Ser Ile Gly Arg Gln Gly Leu Ile Tyr Leu 
        595                 600                 605             


Met Ser Xaa Gly Leu Ala His Phe Xaa Tyr Xaa Asn Phe Cys Leu Pro 
    610                 615                 620                 


Asp Ser Leu Arg Ala Arg Gly Val Leu Ala Ile Pro Asn Tyr His Tyr 
625                 630                 635                 640 


Arg Asp Asp Gly Leu Lys Ile Trp Ala Ala Ile Glu Ser Phe Val Ser 
                645                 650                 655     


Glu Ile Val Gly Tyr Tyr Tyr Pro Ser Asp Ala Ser Val Gln Gln Asp 
            660                 665                 670         


Ser Glu Leu Gln Ala Trp Xaa Gly Glu Ile Phe Ala Gln Ala Phe Leu 
        675                 680                 685             


Gly Arg Glu Ser Ser Gly Phe Pro Ser Arg Leu Cys Xaa Pro Gly Glu 
    690                 695                 700                 


Met Val Lys Phe Leu Xaa Ala Ile Ile Phe Asn Cys Ser Ala Gln His 
705                 710                 715                 720 


Ala Ala Val Asn Ser Gly Gln His Asp Phe Gly Ala Trp Met Pro Asn 
                725                 730                 735     


Ala Pro Ser Ser Met Arg Gln Pro Pro Pro Gln Xaa Lys Gly Xaa Xaa 
            740                 745                 750         


Xaa Leu Lys Xaa Tyr Leu Asp Xaa Leu Pro Glu Val Asn Ile Ser Cys 
        755                 760                 765             


Asn Asn Leu Leu Leu Phe Trp Leu Val Ser Gln Glu Pro Lys Asp Gln 
    770                 775                 780                 


Arg Pro Leu Gly Xaa Tyr Pro Asp Glu His Phe Xaa Glu Glu Ala Pro 
785                 790                 795                 800 


Arg Arg Ser Ile Ala Ala Phe Gln Ser Arg Leu Ala Gln Ile Ser Arg 
                805                 810                 815     


Asp Ile Gln Glu Arg Asn Gln Gly Leu Ala Leu Pro Tyr Xaa Tyr Leu 
            820                 825                 830         


Asp Pro Pro Leu Ile Glu Asn Ser Val Ser Ile 
        835                 840             


<210> 2223
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 2223
Met Asp Ser Lys Lys Arg Ser Ser Xaa Glu Ala Glu Gly Ser Lys Glu 
1               5                   10                  15      


Arg Gly Leu Val His Ile Trp Gln Ala Gly Ser Phe Pro Ile Xaa Pro 
            20                  25                  30          


Glu Arg Leu Pro Gly Trp Gly Gly Lys Xaa Val Leu Gln Ala Ala Leu 
        35                  40                  45              


Gly Val Lys His Gly Val Leu Leu Xaa Glu Asp Gly Glu Val Tyr Ser 
    50                  55                  60                  


Phe Gly Xaa Leu Pro Trp Arg Ser Gly Pro Val Glu Ile Cys Pro Ser 
65                  70                  75                  80  


Ser Pro Ile Leu Glu Asn Ala Leu Val Gly Gln Tyr Val Ile Xaa Val 
                85                  90                  95      


Ala Xaa Gly Ser Phe His Ser Gly Ala Val 
            100                 105     


<210> 2224
<211> 139
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<400> 2224
Met Asp Ser Lys Lys Arg Ser Ser Xaa Glu Ala Glu Gly Ser Lys Glu 
1               5                   10                  15      


Arg Gly Leu Val His Ile Trp Gln Ala Gly Ser Phe Pro Ile Xaa Pro 
            20                  25                  30          


Glu Arg Leu Pro Gly Trp Gly Gly Lys Xaa Val Leu Gln Ala Ala Leu 
        35                  40                  45              


Gly Val Lys His Gly Val Leu Leu Xaa Glu Asp Gly Glu Val Tyr Ser 
    50                  55                  60                  


Phe Gly Xaa Leu Pro Trp Arg Ser Gly Pro Val Glu Ile Cys Pro Ser 
65                  70                  75                  80  


Ser Pro Ile Leu Glu Asn Ala Leu Val Gly Gln Tyr Val Ile Xaa Val 
                85                  90                  95      


Ala Xaa Gly Ser Phe His Ser Gly Ala Val Xaa Asp Asn Gly Val Ala 
            100                 105                 110         


Tyr Met Trp Gly Glu Asn Ser Ala Gly Gln Cys Ala Val Ala Asn Gln 
        115                 120                 125             


Gln Tyr Val Pro Glu Pro Asn Pro Val Ser Ile 
    130                 135                 


<210> 2225
<211> 396
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<400> 2225
Met Asp Ser Lys Lys Arg Ser Ser Xaa Glu Ala Glu Gly Ser Lys Glu 
1               5                   10                  15      


Arg Gly Leu Val His Ile Trp Gln Ala Gly Ser Phe Pro Ile Xaa Pro 
            20                  25                  30          


Glu Arg Leu Pro Gly Trp Gly Gly Lys Xaa Val Leu Gln Ala Ala Leu 
        35                  40                  45              


Gly Val Lys His Gly Val Leu Leu Xaa Glu Asp Gly Glu Val Tyr Ser 
    50                  55                  60                  


Phe Gly Xaa Leu Pro Trp Arg Ser Gly Pro Val Glu Ile Cys Pro Ser 
65                  70                  75                  80  


Ser Pro Ile Leu Glu Asn Ala Leu Val Gly Gln Tyr Val Ile Xaa Val 
                85                  90                  95      


Ala Xaa Gly Ser Phe His Ser Gly Ala Val Xaa Asp Asn Gly Val Ala 
            100                 105                 110         


Tyr Met Trp Gly Glu Asn Ser Ala Gly Gln Cys Ala Val Ala Asn Gln 
        115                 120                 125             


Gln Tyr Val Pro Glu Pro Asn Pro Val Ser Ile Ala Asp Ser Glu Ala 
    130                 135                 140                 


Ser Pro Leu Leu Ala Val Arg Ile Leu Gln Leu Ala Cys Gly Glu Glu 
145                 150                 155                 160 


His Xaa Leu Ala Leu Ser Ile Ser Arg Glu Ile Trp Ala Trp Gly Xaa 
                165                 170                 175     


Gly Cys Gln Leu Gly Leu Ile Xaa Xaa Ala Phe Pro Val Xaa Lys Pro 
            180                 185                 190         


Gln Lys Val Glu His Leu Ala Gly Arg Val Val Leu Gln Val Ala Cys 
        195                 200                 205             


Gly Ala Phe His Ser Leu Ala Leu Val Gln Cys Leu Pro Ser Gln Asp 
    210                 215                 220                 


Leu Lys Pro Val Pro Glu Arg Cys Asn Gln Cys Ser Gln Leu Leu Ile 
225                 230                 235                 240 


Xaa Met Xaa Asp Lys Glu Asp His Val Ile Ile Ser Asp Ser His Cys 
                245                 250                 255     


Cys Pro Leu Gly Val Xaa Leu Xaa Glu Ser Gln Ala Glu Asn His Ala 
            260                 265                 270         


Ser Xaa Ala Leu Ser Pro Ser Xaa Glu Xaa Leu Asp Arg Gln Glu Glu 
        275                 280                 285             


Val Phe Glu Asn Xaa Leu Val Ala Asn Asp Gln Ser Val Ala Xaa Glu 
    290                 295                 300                 


Leu Asn Ala Val Ser Ala Gln Ile Xaa Ser Ser Asp Ala Met Ser Ser 
305                 310                 315                 320 


Gln Gln Asn Val Met Gly Xaa Xaa Glu Ile Ser Ser Ala Arg Asn Ile 
                325                 330                 335     


Pro Ser Tyr Pro Asp Xaa Gln Ala Val Asn Glu Tyr Leu Arg Lys Leu 
            340                 345                 350         


Ser Asp His Ser Val Arg Glu Asp Ser Glu His Gly Glu Lys Pro Val 
        355                 360                 365             


Pro Ser Gln Val Pro Ala Gln Phe Tyr Lys Ile Lys Val Cys Leu Glu 
    370                 375                 380                 


Leu Asn Cys Met Gly Phe Ser Leu Glu Xaa Leu Lys 
385                 390                 395     


<210> 2226
<211> 1657
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1238)..(1238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1260)..(1260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1262)..(1262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1344)..(1344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1346)..(1346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1378)..(1378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1397)..(1397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1439)..(1439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1448)..(1448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1533)..(1533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1546)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1564)..(1565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1567)..(1567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1578)..(1578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1642)..(1643)
<223> Selenocysteine

<400> 2226
Met Asp Ser Lys Lys Arg Ser Ser Xaa Glu Ala Glu Gly Ser Lys Glu 
1               5                   10                  15      


Arg Gly Leu Val His Ile Trp Gln Ala Gly Ser Phe Pro Ile Xaa Pro 
            20                  25                  30          


Glu Arg Leu Pro Gly Trp Gly Gly Lys Xaa Val Leu Gln Ala Ala Leu 
        35                  40                  45              


Gly Val Lys His Gly Val Leu Leu Xaa Glu Asp Gly Glu Val Tyr Ser 
    50                  55                  60                  


Phe Gly Xaa Leu Pro Trp Arg Ser Gly Pro Val Glu Ile Cys Pro Ser 
65                  70                  75                  80  


Ser Pro Ile Leu Glu Asn Ala Leu Val Gly Gln Tyr Val Ile Xaa Val 
                85                  90                  95      


Ala Xaa Gly Ser Phe His Ser Gly Ala Val Xaa Asp Asn Gly Val Ala 
            100                 105                 110         


Tyr Met Trp Gly Glu Asn Ser Ala Gly Gln Cys Ala Val Ala Asn Gln 
        115                 120                 125             


Gln Tyr Val Pro Glu Pro Asn Pro Val Ser Ile Ala Asp Ser Glu Ala 
    130                 135                 140                 


Ser Pro Leu Leu Ala Val Arg Ile Leu Gln Leu Ala Cys Gly Glu Glu 
145                 150                 155                 160 


His Xaa Leu Ala Leu Ser Ile Ser Arg Glu Ile Trp Ala Trp Gly Xaa 
                165                 170                 175     


Gly Cys Gln Leu Gly Leu Ile Xaa Xaa Ala Phe Pro Val Xaa Lys Pro 
            180                 185                 190         


Gln Lys Val Glu His Leu Ala Gly Arg Val Val Leu Gln Val Ala Cys 
        195                 200                 205             


Gly Ala Phe His Ser Leu Ala Leu Val Gln Cys Leu Pro Ser Gln Asp 
    210                 215                 220                 


Leu Lys Pro Val Pro Glu Arg Cys Asn Gln Cys Ser Gln Leu Leu Ile 
225                 230                 235                 240 


Xaa Met Xaa Asp Lys Glu Asp His Val Ile Ile Ser Asp Ser His Cys 
                245                 250                 255     


Cys Pro Leu Gly Val Xaa Leu Xaa Glu Ser Gln Ala Glu Asn His Ala 
            260                 265                 270         


Ser Xaa Ala Leu Ser Pro Ser Xaa Glu Xaa Leu Asp Arg Gln Glu Glu 
        275                 280                 285             


Val Phe Glu Asn Xaa Leu Val Ala Asn Asp Gln Ser Val Ala Xaa Glu 
    290                 295                 300                 


Leu Asn Ala Val Ser Ala Gln Ile Xaa Ser Ser Asp Ala Met Ser Ser 
305                 310                 315                 320 


Gln Gln Asn Val Met Gly Xaa Xaa Glu Ile Ser Ser Ala Arg Asn Ile 
                325                 330                 335     


Pro Ser Tyr Pro Asp Xaa Gln Ala Val Asn Glu Tyr Leu Arg Lys Leu 
            340                 345                 350         


Ser Asp His Ser Val Arg Glu Asp Ser Glu His Gly Glu Lys Pro Val 
        355                 360                 365             


Pro Ser Gln Pro Leu Leu Glu Glu Ala Ile Pro Asn Leu His Ser Pro 
    370                 375                 380                 


Pro Xaa Xaa Ser Xaa Ser Ala Leu Asn Ser Leu Val Val Ser Cys Ala 
385                 390                 395                 400 


Ser Ala Val Gly Val Arg Val Ala Ala Xaa Tyr Glu Ala Gly Ala Leu 
                405                 410                 415     


Ser Leu Lys Lys Val Met Asn Phe Tyr Ser Xaa Xaa Pro Cys Glu Xaa 
            420                 425                 430         


Gly Ala Gln Ala Gly Ser Ser Ala Ile Gly Pro Glu Gly Leu Lys Asp 
        435                 440                 445             


Ser Arg Glu Glu Gln Val Lys Gln Glu Ser Met Gln Gly Lys Lys Ser 
    450                 455                 460                 


Ser Ser Leu Val Asp Ile Arg Glu Glu Glu Xaa Glu Gly Gly Ser Arg 
465                 470                 475                 480 


Arg Leu Ser Leu Pro Gly Leu Leu Ser Gln Val Ser Pro Arg Leu Leu 
                485                 490                 495     


Arg Lys Ala Ala Arg Val Lys Xaa Arg Xaa Val Val Leu Xaa Pro Xaa 
            500                 505                 510         


Tyr Ser Gly Glu Ala Asp Ala Leu Leu Pro Ser Leu Arg Xaa Glu Val 
        515                 520                 525             


Trp Xaa Trp Gly Lys Gly Lys Glu Gly Gln Leu Gly His Gly Asp Val 
    530                 535                 540                 


Leu Pro Arg Leu Gln Pro Leu Cys Val Lys Cys Leu Asp Gly Lys Glu 
545                 550                 555                 560 


Val Ile His Leu Glu Ala Gly Gly Tyr His Ser Leu Ala Leu Xaa Ala 
                565                 570                 575     


Lys Ser Gln Val Tyr Ser Trp Gly Ser Asn Xaa Phe Gly Gln Leu Gly 
            580                 585                 590         


His Ser Asp Phe Pro Xaa Xaa Val Pro Arg Leu Ala Lys Ile Ser Ser 
        595                 600                 605             


Glu Asn Gly Val Trp Ser Ile Ala Ala Gly Arg Asp Tyr Ser Leu Phe 
    610                 615                 620                 


Leu Val Asp Xaa Glu Asp Phe Gln Pro Gly Leu Tyr Tyr Ser Gly Arg 
625                 630                 635                 640 


Gln Asp Pro Xaa Glu Gly Asp Asn Leu Pro Glu Asn His Ser Gly Ser 
                645                 650                 655     


Lys Xaa Pro Val Leu Leu Ser Cys Ser Lys Leu Gly Tyr Ile Ser Arg 
            660                 665                 670         


Val Xaa Ala Gly Lys Asp Ser Tyr Leu Ala Leu Val Asp Lys Asn Ile 
        675                 680                 685             


Met Gly Tyr Ile Ala Ser Leu His Glu Leu Ala Xaa Xaa Glu Arg Arg 
    690                 695                 700                 


Phe Tyr Ser Lys Leu Ser Asp Ile Lys Ser Gln Ile Leu Arg Pro Leu 
705                 710                 715                 720 


Leu Ser Leu Glu Asn Leu Gly Xaa Xaa Xaa Xaa Val Gln Leu Leu Gln 
                725                 730                 735     


Glu Val Ala Ser Arg Phe Ser Lys Leu Cys Tyr Leu Ile Gly Gln His 
            740                 745                 750         


Gly Ala Ser Leu Ser Ser Phe Leu His Gly Val Lys Glu Ala Arg Ser 
        755                 760                 765             


Leu Val Ile Leu Lys His Ser Ser Leu Phe Leu Asp Ser Tyr Xaa Glu 
    770                 775                 780                 


Tyr Cys Xaa Ser Ile Xaa Asn Phe Leu Val Met Gly Gly Phe Gln Leu 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Ile Asp Phe Leu Asn Lys Asn Gln Glu Leu Leu 
                805                 810                 815     


Gln Asp Leu Ser Glu Val Asn Asp Glu Asn Xaa Gln Leu Met Glu Ile 
            820                 825                 830         


Leu Asn Xaa Leu Phe Phe Leu Pro Ile Arg Arg Leu His Asn Tyr Ala 
        835                 840                 845             


Lys Val Leu Leu Lys Leu Ala Xaa Cys Phe Glu Val Ala Ser Pro Glu 
    850                 855                 860                 


Tyr Gln Lys Leu Gln Asp Ser Ser Ser Cys Tyr Glu Cys Leu Ala Leu 
865                 870                 875                 880 


His Leu Gly Arg Lys Arg Lys Glu Ala Glu Tyr Xaa Leu Gly Phe Trp 
                885                 890                 895     


Lys Xaa Phe Pro Gly Lys Met Xaa Asp Ser Leu Arg Lys Pro Glu Arg 
            900                 905                 910         


Arg Leu Leu Cys Glu Ser Ser Asn Arg Ala Leu Ser Leu Gln His Ala 
        915                 920                 925             


Gly Arg Phe Ser Val Asn Trp Phe Ile Leu Phe Asn Asp Ala Leu Val 
    930                 935                 940                 


His Ala Gln Phe Ser Xaa His His Val Phe Pro Leu Ala Xaa Leu Trp 
945                 950                 955                 960 


Ala Glu Pro Leu Ser Glu Glu Ala Gly Gly Val Asn Gly Leu Lys Ile 
                965                 970                 975     


Xaa Xaa Pro Glu Glu Gln Phe Xaa Leu Ile Ser Ser Xaa Pro Gln Glu 
            980                 985                 990         


Lys Xaa Lys Trp Leu Arg Ala Ile  Ser Gln Ala Val Asp  Gln Ala Leu 
        995                 1000                 1005             


Arg Gly  Met Ser Asp Leu Pro  Pro Tyr Gly Ser Gly  Ser Ser Val 
    1010                 1015                 1020             


Gln Arg  Gln Glu Pro Pro Ile  Ser Arg Ser Ala Lys  Tyr Xaa Phe 
    1025                 1030                 1035             


Tyr Lys  Asp Pro Arg Leu Lys  Asp Ala Xaa Tyr Asp  Gly Arg Trp 
    1040                 1045                 1050             


Leu Ser  Gly Lys Pro His Gly  Arg Gly Val Leu Lys  Trp Pro Asp 
    1055                 1060                 1065             


Gly Lys  Met Tyr Ser Gly Met  Phe Arg Asn Gly Leu  Glu Asp Gly 
    1070                 1075                 1080             


Tyr Gly  Glu Tyr Arg Ile Pro  Asn Lys Ala Met Asn  Lys Glu Asp 
    1085                 1090                 1095             


His Tyr  Val Gly His Trp Lys  Glu Gly Lys Met Cys  Gly Gln Gly 
    1100                 1105                 1110             


Val Tyr  Ser Tyr Ala Ser Gly  Glu Val Phe Glu Gly  Cys Phe Gln 
    1115                 1120                 1125             


Asp Asn  Met Arg His Gly His  Gly Leu Leu Arg Ser  Gly Lys Leu 
    1130                 1135                 1140             


Xaa Ser  Ser Ser Pro Ser Met  Phe Ile Gly Gln Trp  Val Met Asp 
    1145                 1150                 1155             


Lys Lys  Ala Gly Tyr Gly Val  Phe Asp Asp Ile Xaa  Arg Gly Glu 
    1160                 1165                 1170             


Lys Tyr  Met Gly Met Trp Gln  Asp Asp Val Cys Gln  Gly Asn Gly 
    1175                 1180                 1185             


Val Val  Val Xaa Gln Phe Gly  Leu Tyr Tyr Glu Gly  Asn Phe His 
    1190                 1195                 1200             


Leu Asn  Lys Met Met Gly Asn  Gly Val Leu Leu Ser  Glu Asp Asp 
    1205                 1210                 1215             


Xaa Ile  Tyr Glu Gly Glu Phe  Ser Asp Asp Trp Xaa  Leu Ser Gly 
    1220                 1225                 1230             


Lys Gly  Xaa Leu Xaa Met Pro  Asn Gly Asp Tyr Ile  Glu Gly Tyr 
    1235                 1240                 1245             


Phe Ser  Gly Glu Trp Gly Ser  Gly Ile Lys Ile Xaa  Gly Xaa Tyr 
    1250                 1255                 1260             


Phe Lys  Pro Ser Leu Tyr Glu  Ser Asp Lys Asp Arg  Pro Lys Val 
    1265                 1270                 1275             


Phe Arg  Lys Leu Gly Asn Leu  Ala Val Pro Ala Asp  Glu Lys Trp 
    1280                 1285                 1290             


Lys Ala  Val Phe Asp Glu Cys  Trp Arg Gln Leu Gly  Cys Glu Gly 
    1295                 1300                 1305             


Pro Gly  Gln Gly Glu Val Trp  Lys Ala Trp Asp Asn  Ile Ala Val 
    1310                 1315                 1320             


Ala Leu  Xaa Xaa Ser Arg Arg  Gln His Arg Asp Ser  Pro Glu Ile 
    1325                 1330                 1335             


Leu Ser  Arg Ser Gln Xaa Gln  Xaa Leu Glu Ser Leu  Glu Phe Ile 
    1340                 1345                 1350             


Pro Gln  His Val Gly Ala Phe  Ser Val Glu Lys Tyr  Asp Asp Ile 
    1355                 1360                 1365             


Arg Lys  Tyr Leu Ile Lys Ala  Cys Asp Xaa Pro Leu  His Pro Leu 
    1370                 1375                 1380             


Gly Arg  Leu Val Glu Xaa Leu  Val Ala Val Tyr Arg  Met Xaa Tyr 
    1385                 1390                 1395             


Val Gly  Val Gly Ala Asn Arg  Arg Leu Leu Gln Glu  Ala Val Lys 
    1400                 1405                 1410             


Glu Ile  Lys Ser Tyr Leu Lys  Arg Ile Phe Gln Leu  Val Arg Phe 
    1415                 1420                 1425             


Leu Phe  Pro Glu Leu Pro Glu  Glu Gly Ser Xaa Ile  Pro Leu Ser 
    1430                 1435                 1440             


Ala Pro  Leu Pro Xaa Glu Arg  Lys Ser Phe Cys Xaa  Gly Lys Ser 
    1445                 1450                 1455             


Asp Ser  Arg Ser Glu Ser Pro  Glu Pro Gly Tyr Val  Val Xaa Ser 
    1460                 1465                 1470             


Ser Gly  Leu Leu Leu Pro Val  Leu Leu Pro Arg Leu  Tyr Pro Pro 
    1475                 1480                 1485             


Leu Phe  Met Leu Tyr Ala Leu  Asp Asn Asp Arg Glu  Glu Asp Ile 
    1490                 1495                 1500             


Tyr Trp  Glu Cys Val Leu Arg  Leu Asn Lys Gln Pro  Asp Ile Ala 
    1505                 1510                 1515             


Leu Leu  Gly Phe Leu Gly Val  Gln Arg Lys Phe Trp  Pro Ala Xaa 
    1520                 1525                 1530             


Leu Ser  Ile Leu Gly Glu Ser  Lys Lys Val Leu Pro  Xaa Xaa Lys 
    1535                 1540                 1545             


Asp Ala  Cys Phe Ala Ser Ala  Val Glu Cys Leu Gln  Gln Ile Ser 
    1550                 1555                 1560             


Xaa Xaa  Phe Xaa Pro Ser Asp  Lys Leu Lys Val Ile  Gln Gln Xaa 
    1565                 1570                 1575             


Phe Glu  Glu Ile Ser Gln Ser  Val Leu Ala Ser Leu  His Glu Asp 
    1580                 1585                 1590             


Phe Leu  Trp Ser Met Asp Asp  Leu Phe Pro Val Phe  Leu Tyr Val 
    1595                 1600                 1605             


Val Leu  Arg Ala Arg Ile Arg  Asn Leu Gly Ser Glu  Val His Leu 
    1610                 1615                 1620             


Ile Glu  Asp Leu Met Asp Pro  Tyr Leu Gln His Gly  Glu Gln Gly 
    1625                 1630                 1635             


Ile Met  Phe Xaa Xaa Leu Lys  Ala Cys Tyr Tyr Gln  Ile Gln Arg 
    1640                 1645                 1650             


Glu Lys  Leu Asn 
    1655         


<210> 2227
<211> 585
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<400> 2227
Xaa Leu Ala Leu Val Asp Lys Asn Ile Met Gly Tyr Ile Ala Ser Leu 
1               5                   10                  15      


His Glu Leu Ala Xaa Xaa Glu Arg Arg Phe Tyr Ser Lys Leu Ser Asp 
            20                  25                  30          


Ile Lys Ser Gln Ile Leu Arg Pro Leu Leu Ser Leu Glu Asn Leu Gly 
        35                  40                  45              


Xaa Xaa Xaa Xaa Val Gln Leu Leu Gln Glu Val Ala Ser Arg Phe Ser 
    50                  55                  60                  


Lys Leu Cys Tyr Leu Ile Gly Gln His Gly Ala Ser Leu Ser Ser Phe 
65                  70                  75                  80  


Leu His Gly Val Lys Glu Ala Arg Ser Leu Val Ile Leu Lys His Ser 
                85                  90                  95      


Ser Leu Phe Leu Asp Ser Tyr Xaa Glu Tyr Cys Xaa Ser Ile Xaa Asn 
            100                 105                 110         


Phe Leu Val Met Gly Gly Phe Gln Leu Leu Ala Lys Pro Ala Ile Asp 
        115                 120                 125             


Phe Leu Asn Lys Asn Gln Glu Leu Leu Gln Asp Leu Ser Glu Val Asn 
    130                 135                 140                 


Asp Glu Asn Xaa Gln Leu Met Glu Ile Leu Asn Xaa Leu Phe Phe Leu 
145                 150                 155                 160 


Pro Ile Arg Arg Leu His Asn Tyr Ala Lys Val Leu Leu Lys Leu Ala 
                165                 170                 175     


Xaa Cys Phe Glu Val Ala Ser Pro Glu Tyr Gln Lys Leu Gln Asp Ser 
            180                 185                 190         


Ser Ser Cys Tyr Glu Cys Leu Ala Leu His Leu Gly Arg Lys Arg Lys 
        195                 200                 205             


Glu Ala Glu Tyr Xaa Leu Gly Phe Trp Lys Xaa Phe Pro Gly Lys Met 
    210                 215                 220                 


Xaa Asp Ser Leu Arg Lys Pro Glu Arg Arg Leu Leu Cys Glu Ser Ser 
225                 230                 235                 240 


Asn Arg Ala Leu Ser Leu Gln His Ala Gly Arg Phe Ser Val Asn Trp 
                245                 250                 255     


Phe Ile Leu Phe Asn Asp Ala Leu Val His Ala Gln Phe Ser Xaa His 
            260                 265                 270         


His Val Phe Pro Leu Ala Xaa Leu Trp Ala Glu Pro Leu Ser Glu Glu 
        275                 280                 285             


Ala Gly Gly Val Asn Gly Leu Lys Ile Xaa Xaa Pro Glu Glu Gln Phe 
    290                 295                 300                 


Xaa Leu Ile Ser Ser Xaa Pro Gln Glu Lys Xaa Lys Trp Leu Arg Ala 
305                 310                 315                 320 


Ile Ser Gln Ala Val Asp Gln Ala Leu Arg Gly Met Ser Asp Leu Pro 
                325                 330                 335     


Pro Tyr Gly Ser Gly Ser Ser Val Gln Arg Gln Glu Pro Pro Ile Ser 
            340                 345                 350         


Arg Ser Ala Lys Tyr Xaa Phe Tyr Lys Asp Pro Arg Leu Lys Asp Ala 
        355                 360                 365             


Xaa Tyr Asp Gly Arg Trp Leu Ser Gly Lys Pro His Gly Arg Gly Val 
    370                 375                 380                 


Leu Lys Trp Pro Asp Gly Lys Met Tyr Ser Gly Met Phe Arg Asn Gly 
385                 390                 395                 400 


Leu Glu Asp Gly Tyr Gly Glu Tyr Arg Ile Pro Asn Lys Ala Met Asn 
                405                 410                 415     


Lys Glu Asp His Tyr Val Gly His Trp Lys Glu Gly Lys Met Cys Gly 
            420                 425                 430         


Gln Gly Val Tyr Ser Tyr Ala Ser Gly Glu Val Phe Glu Gly Cys Phe 
        435                 440                 445             


Gln Asp Asn Met Arg His Gly His Gly Leu Leu Arg Ser Gly Lys Leu 
    450                 455                 460                 


Xaa Ser Ser Ser Pro Ser Met Phe Ile Gly Gln Trp Val Met Asp Lys 
465                 470                 475                 480 


Lys Ala Gly Tyr Gly Val Phe Asp Asp Ile Xaa Arg Gly Glu Lys Tyr 
                485                 490                 495     


Met Gly Met Trp Gln Asp Asp Val Cys Gln Gly Asn Gly Val Val Val 
            500                 505                 510         


Xaa Gln Phe Gly Leu Tyr Tyr Glu Gly Asn Phe His Leu Asn Lys Met 
        515                 520                 525             


Met Gly Asn Gly Val Leu Leu Ser Glu Asp Asp Xaa Ile Tyr Glu Gly 
    530                 535                 540                 


Glu Phe Ser Asp Asp Trp Xaa Leu Ser Gly Lys Asp Asn Ser Gly Leu 
545                 550                 555                 560 


Ile Glu Gln Val Gly Lys Cys Ser Leu Leu Pro Tyr Phe Leu Lys Val 
                565                 570                 575     


Cys Glu Ala Leu Val Leu Phe Leu Leu 
            580                 585 


<210> 2228
<211> 535
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<400> 2228
Met Cys Asn Pro Glu Glu Ala Ala Leu Leu Arg Leu Glu Glu Val Phe 
1               5                   10                  15      


Ser Ala Xaa Leu Ala His Val Asn Ser Leu Val Leu Gln Pro Leu Leu 
            20                  25                  30          


Pro Ala Ala Pro Asp Pro Ser Asp Pro Trp Gly Arg Glu Cys Leu Arg 
        35                  40                  45              


Leu Leu Gln Gln Leu His Lys Ser Ser Gln Gln Leu Trp Glu Val Xaa 
    50                  55                  60                  


Glu Glu Ser Leu His Ser Leu Gln Glu Arg Leu Arg Tyr Pro Asp Ser 
65                  70                  75                  80  


Xaa Gly Leu Glu Ser Leu Leu Leu Leu Arg Gly Ala Asp Arg Val Leu 
                85                  90                  95      


Gln Ala His Ile Glu Tyr Ile Glu Ser Tyr Xaa Ser Cys Met Val Val 
            100                 105                 110         


Gln Ala Phe Gln Lys Ala Ala Lys Arg Arg Ser Glu Tyr Trp Arg Gly 
        115                 120                 125             


Gln Arg Lys Ala Leu Arg Gln Leu Leu Ser Gly Val Ser Ser Glu Gly 
    130                 135                 140                 


Ser Val Gly Ala Ser Leu Gly Gln Ala Leu His Gln Pro Leu Ala His 
145                 150                 155                 160 


His Val Gln Gln Tyr Val Leu Leu Leu Leu Ser Leu Gly Asp Xaa Ile 
                165                 170                 175     


Gly Glu His His Pro Xaa Arg Glu Leu Val Val Asn Ala Val Xaa Leu 
            180                 185                 190         


Phe Gly Asn Leu Gln Ser Phe Met Lys Gln Glu Leu Asp Gln Ala Val 
        195                 200                 205             


Ala Xaa Gln Ala Leu Trp His Xaa Leu Arg Gly Arg Leu Arg Asp Val 
    210                 215                 220                 


Leu Cys Xaa Pro Ala His Arg Leu Leu Gln Asp Ser Gln Asp Val Pro 
225                 230                 235                 240 


Val Xaa Val Ala Pro Leu Arg Ala Glu Arg Val Leu Leu Phe Asp Asp 
                245                 250                 255     


Ala Leu Val Leu Leu Gln Gly His Asn Val His Xaa Phe Asp Leu Lys 
            260                 265                 270         


Leu Val Trp Val Asp Pro Gly Gln Asp Gly Cys Xaa Phe His Leu Leu 
        275                 280                 285             


Xaa Pro Glu Glu Glu Phe Ser Phe Cys Ala Lys Asp Ser Gln Gly Gln 
    290                 295                 300                 


Ala Val Trp Gln Trp Lys Val Xaa Trp Ala Val His Gln Ala Leu His 
305                 310                 315                 320 


Gly Lys Lys Asp Phe Pro Val Leu Gly Ala Gly Leu Glu Pro Ser Gln 
                325                 330                 335     


Pro Pro Asp Cys Arg Cys Ala Glu Tyr Xaa Phe Gln Ala Glu Gly Arg 
            340                 345                 350         


Leu Cys Gln Ala Xaa Tyr Glu Gly Glu Trp Cys Arg Gly Arg Pro His 
        355                 360                 365             


Gly Lys Gly Xaa Leu Lys Trp Pro Asp Gly Arg Asn His Val Gly Asn 
    370                 375                 380                 


Phe Cys Gln Gly Leu Glu His Gly Phe Gly Ile Arg Leu Leu Pro Gln 
385                 390                 395                 400 


Ala Ser Glu Asp Lys Phe Asp Cys Tyr Lys Cys His Trp Arg Glu Gly 
                405                 410                 415     


Ser Met Cys Gly Tyr Gly Ile Cys Xaa Ala Pro Xaa Arg Cys Xaa Arg 
            420                 425                 430         


Ala Xaa Ser Arg Arg Ala Cys Gly Xaa Asp Leu Gly Ser Leu Arg Val 
        435                 440                 445             


Val Arg Arg Pro Pro Ser Pro Ser Gly Xaa Arg Ala Xaa Gly Arg Gly 
    450                 455                 460                 


Ala Arg Gly Ala Ala Met Ala Leu Arg Arg Met Val Xaa Glu Val Ser 
465                 470                 475                 480 


Ala Xaa Leu Ala Cys Gly Arg Leu Val Ser Ala Xaa Ala Gln Gly Ser 
                485                 490                 495     


Trp Ser Pro Arg Gln Val Ser Ala Xaa Arg Ala Pro Ser Arg Arg Xaa 
            500                 505                 510         


Arg Arg Trp Ala Arg Ala Ser Ser Ser Leu Lys Xaa Xaa Pro Cys Met 
        515                 520                 525             


Arg Ala Pro Ser Pro Gly Xaa 
    530                 535 


<210> 2229
<211> 953
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<400> 2229
Met Cys Asn Pro Glu Glu Ala Ala Leu Leu Arg Leu Glu Glu Val Phe 
1               5                   10                  15      


Ser Ala Xaa Leu Ala His Val Asn Ser Leu Val Leu Gln Pro Leu Leu 
            20                  25                  30          


Pro Ala Ala Pro Asp Pro Ser Asp Pro Trp Gly Arg Glu Cys Leu Arg 
        35                  40                  45              


Leu Leu Gln Gln Leu His Lys Ser Ser Gln Gln Leu Trp Glu Val Xaa 
    50                  55                  60                  


Glu Glu Ser Leu His Ser Leu Gln Glu Arg Leu Arg Tyr Pro Asp Ser 
65                  70                  75                  80  


Xaa Gly Leu Glu Ser Leu Leu Leu Leu Arg Gly Ala Asp Arg Val Leu 
                85                  90                  95      


Gln Ala His Ile Glu Tyr Ile Glu Ser Tyr Xaa Ser Cys Met Val Val 
            100                 105                 110         


Gln Ala Phe Gln Lys Ala Ala Lys Arg Arg Ser Glu Tyr Trp Arg Gly 
        115                 120                 125             


Gln Arg Lys Ala Leu Arg Gln Leu Leu Ser Gly Val Ser Ser Glu Gly 
    130                 135                 140                 


Ser Val Gly Ala Ser Leu Gly Gln Ala Leu His Gln Pro Leu Ala His 
145                 150                 155                 160 


His Val Gln Gln Tyr Val Leu Leu Leu Leu Ser Leu Gly Asp Xaa Ile 
                165                 170                 175     


Gly Glu His His Pro Xaa Arg Glu Leu Val Val Asn Ala Val Xaa Leu 
            180                 185                 190         


Phe Gly Asn Leu Gln Ser Phe Met Lys Gln Glu Leu Asp Gln Ala Val 
        195                 200                 205             


Ala Xaa Gln Ala Leu Trp His Xaa Leu Arg Gly Arg Leu Arg Asp Val 
    210                 215                 220                 


Leu Cys Xaa Pro Ala His Arg Leu Leu Gln Asp Ser Gln Asp Val Pro 
225                 230                 235                 240 


Val Xaa Val Ala Pro Leu Arg Ala Glu Arg Val Leu Leu Phe Asp Asp 
                245                 250                 255     


Ala Leu Val Leu Leu Gln Gly His Asn Val His Xaa Phe Asp Leu Lys 
            260                 265                 270         


Leu Val Trp Val Asp Pro Gly Gln Asp Gly Cys Xaa Phe His Leu Leu 
        275                 280                 285             


Xaa Pro Glu Glu Glu Phe Ser Phe Cys Ala Lys Asp Ser Gln Gly Gln 
    290                 295                 300                 


Ala Val Trp Gln Trp Lys Val Xaa Trp Ala Val His Gln Ala Leu His 
305                 310                 315                 320 


Gly Lys Lys Asp Phe Pro Val Leu Gly Ala Gly Leu Glu Pro Ser Gln 
                325                 330                 335     


Pro Pro Asp Cys Arg Cys Ala Glu Tyr Xaa Phe Gln Ala Glu Gly Arg 
            340                 345                 350         


Leu Cys Gln Ala Xaa Tyr Glu Gly Glu Trp Cys Arg Gly Arg Pro His 
        355                 360                 365             


Gly Lys Gly Xaa Leu Lys Trp Pro Asp Gly Arg Asn His Val Gly Asn 
    370                 375                 380                 


Phe Cys Gln Gly Leu Glu His Gly Phe Gly Ile Arg Leu Leu Pro Gln 
385                 390                 395                 400 


Ala Ser Glu Asp Lys Phe Asp Cys Tyr Lys Cys His Trp Arg Glu Gly 
                405                 410                 415     


Ser Met Cys Gly Tyr Gly Ile Cys Glu Tyr Ser Xaa Asp Glu Val Tyr 
            420                 425                 430         


Lys Gly Tyr Phe Gln Glu Gly Leu Arg His Gly Phe Gly Val Leu Glu 
        435                 440                 445             


Ser Gly Pro Gln Ala Pro Gln Pro Phe Arg Tyr Xaa Gly His Trp Glu 
    450                 455                 460                 


Arg Gly Gln Arg Ser Gly Tyr Gly Ile Glu Glu Asp Gly Asp Arg Gly 
465                 470                 475                 480 


Glu Arg Tyr Ile Gly Met Trp Gln Ala Gly Gln Arg His Gly Pro Gly 
                485                 490                 495     


Val Met Val Xaa Gln Ala Gly Val Cys Tyr Gln Gly Xaa Phe Gln Ala 
            500                 505                 510         


Asp Lys Xaa Val Gly Pro Gly Ile Leu Leu Ser Glu Asp Asp Ser Leu 
        515                 520                 525             


Tyr Glu Gly Xaa Phe Xaa Arg Asp Leu Xaa Leu Met Gly Lys Gly Lys 
    530                 535                 540                 


Val Xaa Phe Pro Asn Gly Phe Xaa Leu Glu Gly Ser Phe Gly Ser Gly 
545                 550                 555                 560 


Ala Gly Arg Gly Leu His Xaa Gln Gly Val Leu Asp Xaa Ala Ala Leu 
                565                 570                 575     


Pro Pro Asp Pro Ser Ser Xaa Cys Lys Arg Gln Leu Gly Val Gly Ala 
            580                 585                 590         


Phe Pro Val Glu Ser Arg Trp Gln Gly Val Tyr Ser Pro Phe Arg Asp 
        595                 600                 605             


Phe Val Cys Ala Gly Cys Pro Arg Asp Leu Gln Glu Ala Leu Leu Gly 
    610                 615                 620                 


Phe Asp Val Gln Ser Ser Arg Glu Leu Arg Arg Ser Gln Asp Tyr Leu 
625                 630                 635                 640 


Ser Cys Glu Arg Xaa His Pro Glu Asp Ser Val Gly Ser Met Glu Asp 
                645                 650                 655     


Ile Leu Glu Glu Leu Leu Gln His Arg Glu Pro Lys Ala Leu Gln Leu 
            660                 665                 670         


Tyr Leu Arg Lys Ala Leu Ser Asn Ser Leu His Pro Leu Gly Lys Leu 
        675                 680                 685             


Leu Arg Xaa Leu Met Leu Xaa Phe Gln Ala Xaa Tyr Ala Gly Val Gly 
    690                 695                 700                 


Ala Asn Lys His Leu Gln Glu Leu Ala Gln Glu Glu Val Lys Gln His 
705                 710                 715                 720 


Ala Gln Glu Leu Trp Ala Ala Tyr Arg Gly Leu Leu Arg Val Ala Leu 
                725                 730                 735     


Glu Arg Lys Gly Gln Ala Leu Glu Glu Asp Glu Asp Xaa Glu Xaa Arg 
            740                 745                 750         


Asp Leu Gln Val His Gly Leu Val Leu Pro Leu Met Leu Pro Ser Phe 
        755                 760                 765             


Tyr Ser Glu Leu Phe Xaa Leu Tyr Leu Leu Leu His Glu Arg Glu Asp 
    770                 775                 780                 


Ser Phe Tyr Ser Gln Gly Ile Ala Asn Leu Ser Leu Phe Pro Asp Xaa 
785                 790                 795                 800 


Gln Leu Leu Glu Phe Leu Asp Val Gln Lys His Leu Trp Pro Leu Lys 
                805                 810                 815     


Asp Leu Xaa Leu Xaa Ser Asn Gln Arg Tyr Ser Leu Val Arg Asp Lys 
            820                 825                 830         


Cys Phe Leu Ser Ala Xaa Glu Cys Leu Gln Lys Ile Met Xaa Xaa Val 
        835                 840                 845             


Asp Pro Arg Glu Lys Leu Glu Val Leu Glu Arg Xaa Tyr Gly Glu Ile 
    850                 855                 860                 


Glu Gly Xaa Val Ser Arg Val Leu Gly Arg Glu Tyr Lys Leu Pro Met 
865                 870                 875                 880 


Asp Asp Leu Leu Pro Leu Leu Ile Tyr Val Val Ser Arg Ala Arg Ile 
                885                 890                 895     


Gln His Leu Gly Ala Glu Ile His Leu Ile Arg Asp Met Met Asp Pro 
            900                 905                 910         


Asn His Xaa Gly Gly Leu Tyr Asp Phe Leu Leu Xaa Ala Leu Glu Ser 
        915                 920                 925             


Cys Tyr Glu His Ile Gln Lys Glu Asp Met Arg Leu His Arg Leu Pro 
    930                 935                 940                 


Gly His Trp His Ser Arg Glu Leu Trp 
945                 950             


<210> 2230
<211> 300
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<400> 2230
Met Glu Asp Ile Leu Glu Glu Leu Leu Gln His Arg Glu Pro Lys Ala 
1               5                   10                  15      


Leu Gln Leu Tyr Leu Arg Lys Ala Leu Ser Asn Ser Leu His Pro Leu 
            20                  25                  30          


Gly Lys Leu Leu Arg Xaa Leu Met Leu Xaa Phe Gln Ala Xaa Tyr Ala 
        35                  40                  45              


Gly Val Gly Ala Asn Lys His Leu Gln Glu Leu Ala Gln Glu Glu Val 
    50                  55                  60                  


Lys Gln His Ala Gln Glu Leu Trp Ala Ala Tyr Arg Gly Leu Leu Arg 
65                  70                  75                  80  


Val Ala Leu Glu Arg Lys Gly Gln Ala Leu Glu Glu Asp Glu Asp Xaa 
                85                  90                  95      


Glu Xaa Arg Asp Leu Gln Val His Gly Leu Val Leu Pro Leu Met Leu 
            100                 105                 110         


Pro Ser Phe Tyr Ser Glu Leu Phe Xaa Leu Tyr Leu Leu Leu His Glu 
        115                 120                 125             


Arg Glu Asp Ser Phe Tyr Ser Gln Gly Ile Ala Asn Leu Ser Leu Phe 
    130                 135                 140                 


Pro Asp Xaa Gln Leu Leu Glu Phe Leu Asp Val Gln Lys His Leu Trp 
145                 150                 155                 160 


Pro Leu Lys Asp Leu Xaa Leu Xaa Ser Asn Gln Arg Tyr Ser Leu Val 
                165                 170                 175     


Arg Asp Lys Cys Phe Leu Ser Ala Xaa Glu Cys Leu Gln Lys Ile Met 
            180                 185                 190         


Xaa Xaa Val Asp Pro Arg Glu Lys Leu Glu Val Leu Glu Arg Xaa Tyr 
        195                 200                 205             


Gly Glu Ile Glu Gly Xaa Val Ser Arg Val Leu Gly Arg Glu Tyr Lys 
    210                 215                 220                 


Leu Pro Met Asp Asp Leu Leu Pro Leu Leu Ile Tyr Val Val Ser Arg 
225                 230                 235                 240 


Ala Arg Ile Gln His Leu Gly Ala Glu Ile His Leu Ile Arg Asp Met 
                245                 250                 255     


Met Asp Pro Asn His Xaa Gly Gly Leu Tyr Asp Phe Leu Leu Xaa Ala 
            260                 265                 270         


Leu Glu Ser Cys Tyr Glu His Ile Gln Lys Glu Asp Met Arg Leu His 
        275                 280                 285             


Arg Leu Pro Gly His Trp His Ser Arg Glu Leu Trp 
    290                 295                 300 


<210> 2231
<211> 302
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<400> 2231
Xaa Leu Gln Glu Arg Leu Arg Tyr Pro Asp Ser Xaa Gly Leu Glu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Arg Gly Ala Asp Arg Val Leu Gln Ala His Ile Glu 
            20                  25                  30          


Tyr Ile Glu Ser Tyr Xaa Ser Cys Met Val Val Gln Ala Phe Gln Lys 
        35                  40                  45              


Ala Ala Lys Arg Arg Ser Glu Tyr Trp Arg Gly Gln Arg Lys Ala Leu 
    50                  55                  60                  


Arg Gln Leu Leu Ser Gly Val Ser Ser Glu Gly Ser Val Gly Ala Ser 
65                  70                  75                  80  


Leu Gly Gln Ala Leu His Gln Pro Leu Ala His His Val Gln Gln Tyr 
                85                  90                  95      


Val Leu Leu Leu Leu Ser Leu Gly Asp Xaa Ile Gly Glu His His Pro 
            100                 105                 110         


Xaa Arg Glu Leu Val Val Asn Ala Val Xaa Leu Phe Gly Asn Leu Gln 
        115                 120                 125             


Ser Phe Met Lys Gln Glu Leu Asp Gln Ala Val Ala Xaa Gln Ala Leu 
    130                 135                 140                 


Trp His Xaa Leu Arg Gly Arg Leu Arg Asp Val Leu Cys Xaa Pro Ala 
145                 150                 155                 160 


His Arg Leu Leu Gln Asp Ser Gln Asp Val Pro Val Xaa Val Ala Pro 
                165                 170                 175     


Leu Arg Ala Glu Arg Val Leu Leu Phe Asp Asp Ala Leu Val Leu Leu 
            180                 185                 190         


Gln Gly His Asn Val His Xaa Phe Asp Leu Lys Leu Val Trp Val Asp 
        195                 200                 205             


Pro Gly Gln Asp Gly Cys Xaa Phe His Leu Leu Xaa Pro Glu Glu Glu 
    210                 215                 220                 


Phe Ser Phe Cys Ala Lys Asp Ser Gln Gly Gln Ala Val Trp Gln Trp 
225                 230                 235                 240 


Lys Val Xaa Trp Ala Val His Gln Ala Leu His Gly Lys Lys Asp Phe 
                245                 250                 255     


Pro Val Leu Gly Ala Gly Leu Glu Pro Ser Gln Pro Pro Asp Cys Arg 
            260                 265                 270         


Cys Ala Glu Tyr Xaa Phe Gln Ala Glu Gly Arg Leu Cys Gln Ala Xaa 
        275                 280                 285             


Tyr Glu Gly Glu Trp Cys Arg Gly Arg Pro His Gly Glu Pro 
    290                 295                 300         


<210> 2232
<211> 326
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<400> 2232
Met Glu Phe Leu Ser Glu Lys Phe Ala Leu Lys Ser Pro Pro Ser Lys 
1               5                   10                  15      


Asn Ser Asp Phe Tyr Met Gly Ala Gly Gly Pro Leu Glu His Val Met 
            20                  25                  30          


Glu Xaa Leu Asp Asn Glu Ser Phe Tyr Ser Lys Ala Ser Ala Gly Lys 
        35                  40                  45              


Cys Val Gln Ala Phe Gly Pro Leu Pro Arg Ala Glu His His Val Arg 
    50                  55                  60                  


Leu Glu Arg Xaa Ser Pro Cys Gln Asp Ser Ser Val Asn Tyr Gly Ile 
65                  70                  75                  80  


Xaa Lys Val Glu Gly Gln Pro Leu His Xaa Glu Leu Asn Arg Ala Met 
                85                  90                  95      


Asp Asn Cys Asn Ser Leu Arg Met Ser Pro Val Lys Gly Met Gln Glu 
            100                 105                 110         


Lys Gly Glu Leu Asp Glu Leu Gly Asp Lys Cys Asp Ser Asn Val Ser 
        115                 120                 125             


Ser Ser Lys Lys Arg Arg His Arg Xaa Xaa Phe Xaa Ser Leu Gln Leu 
    130                 135                 140                 


Glu Glu Leu Glu Lys Val Phe Gln Lys Xaa His Tyr Pro Asp Val Tyr 
145                 150                 155                 160 


Val Arg Glu Gln Leu Ala Leu Arg Xaa Glu Leu Xaa Glu Ala Arg Val 
                165                 170                 175     


Gln Val Trp Phe Gln Asn Arg Arg Ala Lys Trp Arg Lys Arg Glu Arg 
            180                 185                 190         


Tyr Gly Gln Ile Gln Gln Ala Lys Ser His Phe Ala Ala Xaa Tyr Asp 
        195                 200                 205             


Ile Ser Val Leu Pro Arg Xaa Asp Ser Tyr Pro Gln Ile Gln Asn Asn 
    210                 215                 220                 


Leu Trp Ala Gly Asn Ala Ser Gly Gly Ser Val Val Xaa Ser Cys Met 
225                 230                 235                 240 


Leu Pro Arg Asp Xaa Ser Ser Cys Met Xaa Pro Tyr Ser His Ser Pro 
                245                 250                 255     


Arg Xaa Asp Ser Ser Tyr Xaa Gly Phe Ser Asn His Gln Asn Gln Phe 
            260                 265                 270         


Ser His Val Pro Leu Asn Asn Phe Phe Xaa Asp Ser Leu Leu Xaa Gly 
        275                 280                 285             


Ala Xaa Asn Gly His Ala Phe Glu Xaa Lys Pro Glu Phe Glu Arg Arg 
    290                 295                 300                 


Ser Ser Ser Ile Ala Val Leu Arg Met Lys Ala Lys Glu His Xaa Ala 
305                 310                 315                 320 


Asn Ile Ser Trp Ala Met 
                325     


<210> 2233
<211> 343
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(343)
<223> Selenocysteine

<400> 2233
Met Asp Pro Glu His Cys Ala Pro Phe Arg Val Gly Pro Ala Pro Gly 
1               5                   10                  15      


Pro Tyr Val Ala Ser Gly Asp Glu Pro Pro Gly Pro Gln Gly Xaa Pro 
            20                  25                  30          


Ala Ala Ala Pro His Leu His Pro Ala Pro Pro Arg Gly Pro Arg Leu 
        35                  40                  45              


Xaa Arg Phe Pro Ala Cys Gly Pro Leu Glu Pro Tyr Leu Pro Glu Pro 
    50                  55                  60                  


Ala Lys Pro Pro Ala Lys Tyr Leu Gln Asp Leu Gly Pro Gly Pro Ala 
65                  70                  75                  80  


Leu Asn Gly Gly His Phe Tyr Glu Gly Pro Ala Glu Ala Glu Glu Lys 
                85                  90                  95      


Xaa Ser Lys Ala Ala Ser Phe Pro Gln Leu Pro Leu Asp Cys Arg Gly 
            100                 105                 110         


Gly Pro Arg Asp Gly Pro Ser Asn Leu Gln Gly Ser Pro Gly Pro Cys 
        115                 120                 125             


Leu Ala Ser Leu His Leu Pro Leu Ser Pro Gly Leu Pro Asp Ser Met 
    130                 135                 140                 


Glu Leu Ala Lys Asn Lys Ser Lys Lys Arg Arg Asn Arg Xaa Xaa Phe 
145                 150                 155                 160 


Ser Xaa Phe Gln Leu Glu Glu Leu Glu Lys Val Phe Gln Lys Xaa His 
                165                 170                 175     


Tyr Pro Asp Val Tyr Ala Arg Glu Gln Leu Ala Leu Arg Xaa Asp Leu 
            180                 185                 190         


Xaa Glu Ala Arg Val Gln Val Trp Phe Gln Asn Arg Arg Ala Lys Trp 
        195                 200                 205             


Arg Lys Arg Glu Arg Tyr Gly Lys Ile Gln Glu Gly Arg Asn Pro Phe 
    210                 215                 220                 


Xaa Ala Ala Tyr Asp Ile Ser Val Leu Pro Arg Xaa Asp Ser His Pro 
225                 230                 235                 240 


Gln Leu Gln Asn Ser Leu Trp Ala Ser Pro Gly Ser Gly Ser Pro Gly 
                245                 250                 255     


Gly Pro Cys Leu Val Ser Pro Glu Gly Ile Pro Ser Pro Cys Met Ser 
            260                 265                 270         


Pro Tyr Ser His Pro His Gly Ser Val Ala Gly Phe Met Gly Val Pro 
        275                 280                 285             


Ala Pro Ser Ala Ala His Pro Gly Ile Tyr Ser Ile His Gly Phe Pro 
    290                 295                 300                 


Pro Xaa Leu Gly Gly His Ser Phe Glu Pro Ser Ser Asp Gly Asp Tyr 
305                 310                 315                 320 


Lys Ser Pro Ser Leu Val Ser Leu Arg Val Lys Pro Lys Glu Pro Pro 
                325                 330                 335     


Gly Leu Leu Asn Trp Xaa Xaa 
            340             


<210> 2234
<211> 411
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<400> 2234
Met Asn Ala Glu Xaa Cys Val Ser Tyr Cys Glu Ser Pro Ala Ala Ala 
1               5                   10                  15      


Met Asp Ala Tyr Tyr Ser Pro Val Ser Gln Ser Arg Glu Gly Ser Ser 
            20                  25                  30          


Pro Phe Arg Ala Phe Pro Gly Gly Asp Lys Phe Gly Xaa Xaa Phe Leu 
        35                  40                  45              


Ser Ala Ala Ala Lys Ala Gln Gly Phe Gly Asp Ala Lys Ser Arg Ala 
    50                  55                  60                  


Arg Tyr Gly Ala Gly Gln Gln Asp Leu Ala Xaa Pro Leu Glu Ser Gly 
65                  70                  75                  80  


Ala Gly Ala Arg Gly Ser Phe Asn Lys Phe Gln Pro Gln Pro Ser Xaa 
                85                  90                  95      


Pro Gln Pro Gln Pro Pro Pro Gln Pro Gln Pro Gln Gln Gln Gln Pro 
            100                 105                 110         


Gln Pro Gln Pro Pro Ala Gln Pro His Leu Tyr Leu Gln Arg Gly Ala 
        115                 120                 125             


Cys Lys Xaa Pro Pro Asp Gly Ser Leu Lys Leu Gln Glu Gly Ser Ser 
    130                 135                 140                 


Gly His Ser Ala Ala Leu Gln Val Pro Cys Tyr Ala Lys Glu Ser Ser 
145                 150                 155                 160 


Leu Gly Glu Pro Glu Leu Pro Pro Asp Ser Asp Xaa Val Gly Met Asp 
                165                 170                 175     


Ser Ser Tyr Leu Ser Val Lys Glu Ala Gly Val Lys Gly Pro Gln Asp 
            180                 185                 190         


Arg Ala Ser Ser Asp Leu Pro Ser Pro Leu Glu Lys Ala Asp Ser Glu 
        195                 200                 205             


Ser Asn Lys Gly Lys Lys Arg Arg Asn Arg Xaa Xaa Phe Xaa Ser Tyr 
    210                 215                 220                 


Gln Leu Glu Glu Leu Glu Lys Val Phe Gln Lys Xaa His Tyr Pro Asp 
225                 230                 235                 240 


Val Tyr Ala Arg Glu Gln Leu Ala Met Arg Xaa Asp Leu Xaa Glu Ala 
                245                 250                 255     


Arg Val Gln Val Trp Phe Gln Asn Arg Arg Ala Lys Trp Arg Lys Arg 
            260                 265                 270         


Glu Arg Phe Gly Gln Met Gln Gln Val Arg Xaa His Phe Ser Xaa Ala 
        275                 280                 285             


Tyr Glu Leu Pro Leu Leu Xaa Arg Ala Glu Asn Tyr Ala Gln Ile Gln 
    290                 295                 300                 


Asn Pro Ser Trp Leu Gly Asn Asn Gly Ala Ala Ser Pro Val Pro Ala 
305                 310                 315                 320 


Cys Val Val Pro Cys Asp Pro Val Pro Ala Cys Met Ser Pro His Ala 
                325                 330                 335     


His Pro Pro Gly Ser Gly Ala Ser Ser Val Xaa Asp Phe Leu Ser Val 
            340                 345                 350         


Ser Gly Ala Gly Ser His Val Gly Gln Xaa His Met Gly Ser Leu Phe 
        355                 360                 365             


Gly Ala Ala Ser Leu Ser Pro Gly Leu Asn Gly Tyr Glu Leu Asn Gly 
    370                 375                 380                 


Glu Pro Asp Arg Lys Xaa Ser Ser Ile Ala Ala Leu Arg Met Lys Ala 
385                 390                 395                 400 


Lys Glu His Ser Ala Ala Ile Ser Trp Ala Xaa 
                405                 410     


<210> 2235
<211> 205
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<400> 2235
Met Gly Xaa Trp Ile Leu Phe Ala Cys Leu Leu Gly Ala Ala Phe Ala 
1               5                   10                  15      


Met Pro Leu Pro Pro His Pro Gly His Pro Gly Tyr Ile Asn Phe Ser 
            20                  25                  30          


Tyr Glu Asn Ser His Ser Gln Ala Ile Asn Val Asp Arg Xaa Ala Leu 
        35                  40                  45              


Val Leu Xaa Pro Leu Lys Trp Tyr Gln Ser Ile Arg Pro Pro Tyr Pro 
    50                  55                  60                  


Ser Tyr Gly Tyr Glu Pro Met Gly Gly Trp Leu His His Gln Ile Ile 
65                  70                  75                  80  


Pro Val Leu Ser Gln Gln His Pro Pro Xaa His Xaa Leu Gln Pro His 
                85                  90                  95      


His His Ile Pro Val Val Pro Ala Gln Gln Pro Val Ile Pro Gln Gln 
            100                 105                 110         


Pro Met Met Pro Val Pro Gly Gln His Ser Met Xaa Pro Ile Gln His 
        115                 120                 125             


His Gln Pro Asn Leu Pro Pro Pro Ala Gln Gln Pro Tyr Gln Pro Gln 
    130                 135                 140                 


Pro Val Gln Pro Gln Pro His Gln Pro Met Gln Pro Gln Pro Pro Val 
145                 150                 155                 160 


His Pro Met Gln Pro Leu Pro Pro Gln Pro Pro Leu Pro Pro Met Phe 
                165                 170                 175     


Pro Met Gln Pro Leu Pro Pro Met Leu Pro Asp Leu Xaa Leu Glu Ala 
            180                 185                 190         


Trp Pro Ser Xaa Asp Lys Xaa Lys Arg Glu Glu Val Asp 
        195                 200                 205 


<210> 2236
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<400> 2236
Met Gly Xaa Trp Ile Leu Phe Ala Cys Leu Leu Gly Ala Ala Phe Ala 
1               5                   10                  15      


Met Pro Leu Pro Pro His Pro Gly His Pro Gly Tyr Ile Asn Phe Ser 
            20                  25                  30          


Tyr Glu Val Leu Xaa Pro Leu Lys Trp Tyr Gln Ser Ile Arg Pro Pro 
        35                  40                  45              


Tyr Pro Ser Tyr Gly Tyr Glu Pro Met Gly Gly Trp Leu His His Gln 
    50                  55                  60                  


Ile Ile Pro Val Leu Ser Gln Gln His Pro Pro Xaa His Xaa Leu Gln 
65                  70                  75                  80  


Pro His His His Ile Pro Val Val Pro Ala Gln Gln Pro Val Ile Pro 
                85                  90                  95      


Gln Gln Pro Met Met Pro Val Pro Gly Gln His Ser Met Xaa Pro Ile 
            100                 105                 110         


Gln His His Gln Pro Asn Leu Pro Pro Pro Ala Gln Gln Pro Tyr Gln 
        115                 120                 125             


Pro Gln Pro Val Gln Pro Gln Pro His Gln Pro Met Gln Pro Gln Pro 
    130                 135                 140                 


Pro Val His Pro Met Gln Pro Leu Pro Pro Gln Pro Pro Leu Pro Pro 
145                 150                 155                 160 


Met Phe Pro Met Gln Pro Leu Pro Pro Met Leu Pro Asp Leu Xaa Leu 
                165                 170                 175     


Glu Ala Trp Pro Ser Xaa Asp Lys Xaa Lys Arg Glu Glu Val Asp 
            180                 185                 190     


<210> 2237
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 2237
Met Gly Xaa Trp Ile Leu Phe Ala Cys Leu Leu Gly Ala Ala Phe Ala 
1               5                   10                  15      


Met Pro Val Leu Xaa Pro Leu Lys Trp Tyr Gln Ser Ile Arg Pro Pro 
            20                  25                  30          


Tyr Pro Ser Tyr Gly Tyr Glu Pro Met Gly Gly Trp Leu His His Gln 
        35                  40                  45              


Ile Ile Pro Val Leu Ser Gln Gln His Pro Pro Xaa His Xaa Leu Gln 
    50                  55                  60                  


Pro His His His Ile Pro Val Val Pro Ala Gln Gln Pro Val Ile Pro 
65                  70                  75                  80  


Gln Gln Pro Met Met Pro Val Pro Gly Gln His Ser Met Xaa Pro Ile 
                85                  90                  95      


Gln His His Gln Pro Asn Leu Pro Pro Pro Ala Gln Gln Pro Tyr Gln 
            100                 105                 110         


Pro Gln Pro Val Gln Pro Gln Pro His Gln Pro Met Gln Pro Gln Pro 
        115                 120                 125             


Pro Val His Pro Met Gln Pro Leu Pro Pro Gln Pro Pro Leu Pro Pro 
    130                 135                 140                 


Met Phe Pro Met Gln Pro Leu Pro Pro Met Leu Pro Asp Leu Xaa Leu 
145                 150                 155                 160 


Glu Ala Trp Pro Ser Xaa Asp Lys Xaa Lys Arg Glu Glu Val Asp 
                165                 170                 175 


<210> 2238
<211> 804
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<400> 2238
Met Glu Xaa Gln Lys Asp Glu Ala Ala Gln Ala Lys Gly Ala Ala Ala 
1               5                   10                  15      


Ser Gly Ser Xaa Arg Glu Gln Xaa Ala Glu Lys Gly Ala Lys Asn Lys 
            20                  25                  30          


Ala Ala Glu Ala Xaa Glu Gly Pro Xaa Ser Glu Pro Ser Ser Ser Gly 
        35                  40                  45              


Pro Gly Arg Leu Lys Lys Xaa Ala Met Lys Leu Phe Gly Gly Lys Lys 
    50                  55                  60                  


Gly Ile Cys Xaa Leu Pro Ser Phe Phe Gly Gly Gly Arg Ser Lys Gly 
65                  70                  75                  80  


Ser Gly Lys Gly Ser Ser Lys Lys Gly Leu Ser Lys Ser Lys Xaa His 
                85                  90                  95      


Asp Gly Leu Ser Glu Ala Ala His Gly Pro Glu Asp Val Val Ser Glu 
            100                 105                 110         


Gly Xaa Gly Phe Ser Leu Pro Leu Pro Glu Leu Pro Cys Gln Phe Pro 
        115                 120                 125             


Ser Ser Gln Ser Ala His Gly Ala Leu Glu Xaa Gly Ser Arg Cys Lys 
    130                 135                 140                 


Xaa Ser Val Ala Gly Ala Xaa Glu Lys Ala Val Ala Glu Lys Phe Pro 
145                 150                 155                 160 


Ser Met Pro Lys Pro Lys Lys Gly Leu Lys Gly Phe Phe Ser Ser Ile 
                165                 170                 175     


Arg Arg His Arg Lys Ser Lys Val Xaa Gly Ala Glu Gln Ser Glu Pro 
            180                 185                 190         


Gly Ala Lys Gly Pro Glu Arg Val Arg Ala Arg Pro His Glu His Val 
        195                 200                 205             


Ser Ser Ala Pro Gln Val Pro Cys Phe Glu Glu Xaa Phe Gln Ala Pro 
    210                 215                 220                 


Arg Lys Glu Asn Ala Asn Pro Gln Asp Ala Pro Gly Pro Lys Val Ser 
225                 230                 235                 240 


Pro Xaa Pro Glu Pro Ser Pro Pro Ala Xaa Glu Lys Met Ala Cys Lys 
                245                 250                 255     


Asp Pro Glu Lys Pro Met Glu Ala Cys Ala Ser Ala His Val Gln Pro 
            260                 265                 270         


Lys Pro Ala Pro Glu Ala Ser Ser Leu Glu Glu Pro His Ser Pro Glu 
        275                 280                 285             


Xaa Gly Glu Lys Val Val Ala Gly Glu Val Asn Pro Pro Asn Gly Pro 
    290                 295                 300                 


Val Gly Asp Pro Leu Ser Leu Leu Phe Gly Asp Val Xaa Ser Leu Lys 
305                 310                 315                 320 


Ser Phe Asp Ser Leu Xaa Gly Cys Gly Asp Ile Ile Ala Glu Gln Asp 
                325                 330                 335     


Met Asp Ser Met Xaa Asp Ser Met Ala Ser Gly Gly Gln Arg Ala Asn 
            340                 345                 350         


Arg Asp Gly Xaa Lys Arg Ser Ser Cys Leu Val Xaa Tyr Gln Gly Gly 
        355                 360                 365             


Gly Glu Glu Met Ala Leu Pro Asp Asp Asp Asp Glu Glu Glu Glu Glu 
    370                 375                 380                 


Glu Glu Glu Val Glu Leu Glu Glu Glu Glu Glu Glu Val Lys Glu Glu 
385                 390                 395                 400 


Glu Glu Asp Asp Asp Leu Glu Tyr Leu Trp Glu Xaa Ala Gln Met Tyr 
                405                 410                 415     


Pro Arg Pro Asn Met Asn Leu Gly Tyr His Pro Xaa Xaa Ser Pro Gly 
            420                 425                 430         


His His Gly Tyr Met Leu Leu Asp Pro Val Arg Ser Tyr Pro Gly Leu 
        435                 440                 445             


Ala Pro Gly Glu Leu Leu Xaa Pro Gln Ser Asp Gln Gln Glu Ser Ala 
    450                 455                 460                 


Pro Asn Ser Asp Glu Gly Tyr Tyr Asp Ser Xaa Xaa Pro Gly Phe Glu 
465                 470                 475                 480 


Asp Asp Ser Gly Glu Ala Leu Gly Leu Val Arg Arg Asp Cys Leu Pro 
                485                 490                 495     


Arg Asp Ser Tyr Ser Gly Asp Ala Leu Tyr Glu Phe Tyr Glu Pro Asp 
            500                 505                 510         


Asp Ser Leu Glu Asn Ser Pro Pro Gly Asp Asp Cys Leu Tyr Asp Leu 
        515                 520                 525             


His Gly Arg Ser Ser Glu Met Phe Asp Pro Phe Leu Asn Phe Glu Pro 
    530                 535                 540                 


Phe Leu Ser Ser Arg Pro Pro Gly Ala Met Glu Xaa Glu Glu Glu Arg 
545                 550                 555                 560 


Leu Val Xaa Ile Gln Lys Gln Leu Leu Tyr Trp Glu Leu Arg Arg Glu 
                565                 570                 575     


Gln Leu Glu Ala Gln Glu Ala Arg Ala Arg Glu Ala His Ala Arg Glu 
            580                 585                 590         


Ala His Ala Arg Glu Ala Tyr Xaa Arg Glu Ala Tyr Gly Arg Glu Ala 
        595                 600                 605             


Tyr Ala Arg Glu Ala His Xaa Trp Glu Ala His Gly Arg Glu Ala Arg 
    610                 615                 620                 


Xaa Arg Glu Ala Gln Ala Arg Glu Val Arg Cys Arg Glu Xaa Gln Val 
625                 630                 635                 640 


Arg Glu Xaa Gln Ala Arg Gln Glu Lys Pro Val Leu Glu Tyr Gln Met 
                645                 650                 655     


Arg Pro Leu Gly Pro Ser Val Met Gly Leu Ala Ala Gly Val Ser Gly 
            660                 665                 670         


Xaa Ser Gln Ile Ser His Arg Gly Ile Xaa Ser Ala Phe Pro Xaa Xaa 
        675                 680                 685             


Ala Ser Ser Glu Pro Asp Trp Arg Asp Phe Arg Pro Leu Glu Lys Arg 
    690                 695                 700                 


Tyr Glu Gly Xaa Cys Ser Lys Lys Asp Gln Ser Xaa Cys Leu Met Gln 
705                 710                 715                 720 


Leu Phe Gln Ser Asp Ala Met Phe Glu Pro Asp Met Gln Glu Ala Asn 
                725                 730                 735     


Phe Gly Gly Ser Pro Arg Arg Ala Tyr Pro Xaa Tyr Ser Pro Pro Glu 
            740                 745                 750         


Asp Pro Glu Glu Glu Glu Val Glu Lys Glu Gly Asn Ala Xaa Val Ser 
        755                 760                 765             


Phe Ser Gln Ala Leu Val Glu Phe Xaa Ser Asn Gly Asn Leu Phe Ser 
    770                 775                 780                 


Ser Ile Arg Cys Pro Gly Xaa Glu Asp Lys Arg Gln Val Xaa Gln Ala 
785                 790                 795                 800 


Cys Gly Xaa Trp 
                


<210> 2239
<211> 1135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<400> 2239
Met Glu Xaa Gln Lys Asp Glu Ala Ala Gln Ala Lys Gly Ala Ala Ala 
1               5                   10                  15      


Ser Gly Ser Xaa Arg Glu Gln Xaa Ala Glu Lys Gly Ala Lys Asn Lys 
            20                  25                  30          


Ala Ala Glu Ala Xaa Glu Gly Pro Xaa Ser Glu Pro Ser Ser Ser Gly 
        35                  40                  45              


Pro Gly Arg Leu Lys Lys Xaa Ala Met Lys Leu Phe Gly Gly Lys Lys 
    50                  55                  60                  


Gly Ile Cys Xaa Leu Pro Ser Phe Phe Gly Gly Gly Arg Ser Lys Gly 
65                  70                  75                  80  


Ser Gly Lys Gly Ser Ser Lys Lys Gly Leu Ser Lys Ser Lys Xaa His 
                85                  90                  95      


Asp Gly Leu Ser Glu Ala Ala His Gly Pro Glu Asp Val Val Ser Glu 
            100                 105                 110         


Gly Xaa Gly Phe Ser Leu Pro Leu Pro Glu Leu Pro Cys Gln Phe Pro 
        115                 120                 125             


Ser Ser Gln Ser Ala His Gly Ala Leu Glu Xaa Gly Ser Arg Cys Lys 
    130                 135                 140                 


Xaa Ser Val Ala Gly Ala Xaa Glu Lys Ala Val Ala Glu Lys Phe Pro 
145                 150                 155                 160 


Ser Met Pro Lys Pro Lys Lys Gly Leu Lys Gly Phe Phe Ser Ser Ile 
                165                 170                 175     


Arg Arg His Arg Lys Ser Lys Val Xaa Gly Ala Glu Gln Ser Glu Pro 
            180                 185                 190         


Gly Ala Lys Gly Pro Glu Arg Val Arg Ala Arg Pro His Glu His Val 
        195                 200                 205             


Ser Ser Ala Pro Gln Val Pro Cys Phe Glu Glu Xaa Phe Gln Ala Pro 
    210                 215                 220                 


Arg Lys Glu Asn Ala Asn Pro Gln Asp Ala Pro Gly Pro Lys Val Ser 
225                 230                 235                 240 


Pro Xaa Pro Glu Pro Ser Pro Pro Ala Xaa Glu Lys Met Ala Cys Lys 
                245                 250                 255     


Asp Pro Glu Lys Pro Met Glu Ala Cys Ala Ser Ala His Val Gln Pro 
            260                 265                 270         


Lys Pro Ala Pro Glu Ala Ser Ser Leu Glu Glu Pro His Ser Pro Glu 
        275                 280                 285             


Xaa Gly Glu Lys Val Val Ala Gly Glu Val Asn Pro Pro Asn Gly Pro 
    290                 295                 300                 


Val Gly Asp Pro Leu Ser Leu Leu Phe Gly Asp Val Xaa Ser Leu Lys 
305                 310                 315                 320 


Ser Phe Asp Ser Leu Xaa Gly Cys Gly Asp Ile Ile Ala Glu Gln Asp 
                325                 330                 335     


Met Asp Ser Met Xaa Asp Ser Met Ala Ser Gly Gly Gln Arg Ala Asn 
            340                 345                 350         


Arg Asp Gly Xaa Lys Arg Ser Ser Cys Leu Val Xaa Tyr Gln Gly Gly 
        355                 360                 365             


Gly Glu Glu Met Ala Leu Pro Asp Asp Asp Asp Glu Glu Glu Glu Glu 
    370                 375                 380                 


Glu Glu Glu Val Glu Leu Glu Glu Glu Glu Glu Glu Val Lys Glu Glu 
385                 390                 395                 400 


Glu Glu Asp Asp Asp Leu Glu Tyr Leu Trp Glu Xaa Ala Gln Met Tyr 
                405                 410                 415     


Pro Arg Pro Asn Met Asn Leu Gly Tyr His Pro Xaa Xaa Ser Pro Gly 
            420                 425                 430         


His His Gly Tyr Met Leu Leu Asp Pro Val Arg Ser Tyr Pro Gly Leu 
        435                 440                 445             


Ala Pro Gly Glu Leu Leu Xaa Pro Gln Ser Asp Gln Gln Glu Ser Ala 
    450                 455                 460                 


Pro Asn Ser Asp Glu Gly Tyr Tyr Asp Ser Xaa Xaa Pro Gly Phe Glu 
465                 470                 475                 480 


Asp Asp Ser Gly Glu Ala Leu Gly Leu Val Arg Arg Asp Cys Leu Pro 
                485                 490                 495     


Arg Asp Ser Tyr Ser Gly Asp Ala Leu Tyr Glu Phe Tyr Glu Pro Asp 
            500                 505                 510         


Asp Ser Leu Glu Asn Ser Pro Pro Gly Asp Asp Cys Leu Tyr Asp Leu 
        515                 520                 525             


His Gly Arg Ser Ser Glu Met Phe Asp Pro Phe Leu Asn Phe Glu Pro 
    530                 535                 540                 


Phe Leu Ser Ser Arg Pro Pro Gly Ala Met Glu Xaa Glu Glu Glu Arg 
545                 550                 555                 560 


Leu Val Xaa Ile Gln Lys Gln Leu Leu Tyr Trp Glu Leu Arg Arg Glu 
                565                 570                 575     


Gln Leu Glu Ala Gln Glu Ala Arg Ala Arg Glu Ala His Ala Arg Glu 
            580                 585                 590         


Ala His Ala Arg Glu Ala Tyr Xaa Arg Glu Ala Tyr Gly Arg Glu Ala 
        595                 600                 605             


Tyr Ala Arg Glu Ala His Xaa Trp Glu Ala His Gly Arg Glu Ala Arg 
    610                 615                 620                 


Xaa Arg Glu Ala Gln Ala Arg Glu Val Arg Cys Arg Glu Xaa Gln Val 
625                 630                 635                 640 


Arg Glu Xaa Gln Ala Arg Gln Glu Lys Pro Val Leu Glu Tyr Gln Met 
                645                 650                 655     


Arg Pro Leu Gly Pro Ser Val Met Gly Leu Ala Ala Gly Val Ser Gly 
            660                 665                 670         


Xaa Ser Gln Ile Ser His Arg Gly Ile Xaa Ser Ala Phe Pro Xaa Xaa 
        675                 680                 685             


Ala Ser Ser Glu Pro Asp Trp Arg Asp Phe Arg Pro Leu Glu Lys Arg 
    690                 695                 700                 


Tyr Glu Gly Xaa Cys Ser Lys Lys Asp Gln Ser Xaa Cys Leu Met Gln 
705                 710                 715                 720 


Leu Phe Gln Ser Asp Ala Met Phe Glu Pro Asp Met Gln Glu Ala Asn 
                725                 730                 735     


Phe Gly Gly Ser Pro Arg Arg Ala Tyr Pro Xaa Tyr Ser Pro Pro Glu 
            740                 745                 750         


Asp Pro Glu Glu Glu Glu Val Glu Lys Glu Gly Asn Ala Xaa Val Ser 
        755                 760                 765             


Phe Ser Gln Ala Leu Val Glu Phe Xaa Ser Asn Gly Asn Leu Phe Ser 
    770                 775                 780                 


Ser Met Ser Cys Ser Ser Asp Ser Asp Ser Ser Phe Xaa Gln Asn Leu 
785                 790                 795                 800 


Pro Glu Leu Pro Pro Met Val Xaa Phe Asp Ile Ala Asp Val Glu Arg 
                805                 810                 815     


Asp Gly Glu Gly Lys Cys Glu Glu Asn Pro Glu Phe His Asn Asp Glu 
            820                 825                 830         


Asp Leu Ala Ala Ser Leu Glu Ala Phe Glu Leu Gly Tyr Tyr His Lys 
        835                 840                 845             


His Ala Phe Asn Asn Tyr His Ser Arg Phe Tyr Gln Gly Leu Pro Trp 
    850                 855                 860                 


Gly Val Ser Ser Leu Pro Arg Tyr Leu Gly Leu Pro Gly Leu His Pro 
865                 870                 875                 880 


Arg Pro Pro Pro Ala Ala Met Ala Leu Asn Arg Arg Ser Arg Ser Leu 
                885                 890                 895     


Asp Xaa Ala Glu Xaa Leu Glu Met Glu Leu Ser Asn Ser His Leu Val 
            900                 905                 910         


Gln Gly Tyr Leu Glu Ser Asp Glu Leu Gln Ala Gln Gln Glu Asp Ser 
        915                 920                 925             


Asp Glu Glu Asp Glu Glu Glu Glu Glu Gly Glu Trp Ser Arg Asp Ser 
    930                 935                 940                 


Pro Leu Ser Leu Tyr Xaa Glu Pro Pro Gly Ala Tyr Asp Trp Pro Ala 
945                 950                 955                 960 


Trp Ala Pro Cys Pro Leu Pro Val Gly Pro Gly Pro Ala Trp Ile Ser 
                965                 970                 975     


Pro Asn Gln Leu Asp Arg Pro Ser Ser Gln Ser Pro Tyr Arg Gln Ala 
            980                 985                 990         


Xaa Cys Cys Ile Pro Pro Met Xaa  Met Ser Ile Ser Leu  Ser Val Pro 
        995                 1000                 1005             


Glu Ser  Arg Ala Pro Gly Glu  Ser Gly Pro Gln Leu  Ala Arg Pro 
    1010                 1015                 1020             


Ser His  Leu His Leu Pro Met  Gly Pro Cys Tyr Asn  Leu Gln Pro 
    1025                 1030                 1035             


Gln Ala  Ser Gln Ser Met Arg  Ala Arg Pro Arg Asp  Val Leu Leu 
    1040                 1045                 1050             


Pro Val  Asp Glu Pro Ser Cys  Ser Ser Ser Ser Gly  Gly Phe Ser 
    1055                 1060                 1065             


Pro Ser  Pro Leu Pro Gln Ala  Lys Pro Val Gly Ile  Xaa His Gly 
    1070                 1075                 1080             


Ile Pro  Gln Leu Pro Arg Val  Arg Pro Glu His Pro  Gln Pro Gln 
    1085                 1090                 1095             


Pro Xaa  His Tyr Gly Pro Ser  Ser Leu Asp Leu Ser  Lys Glu Arg 
    1100                 1105                 1110             


Ala Glu  Gln Gly Ala Ser Leu  Ala Xaa Ser Tyr Ser  Ser Xaa Ala 
    1115                 1120                 1125             


Met Asn  Gly Asn Leu Ala Lys  
    1130                 1135 


<210> 2240
<211> 552
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<400> 2240
Met Glu Xaa Ser Arg Ser Arg Gly Gly Gly Gly Ala Val Ser Glu Arg 
1               5                   10                  15      


Gly Gly Ala Gly Ala Ser Val Gly Val Cys Arg Arg Lys Ala Glu Ala 
            20                  25                  30          


Gly Ala Gly Xaa Gly Xaa Leu Ala Ala Asp Met Asp Leu His Cys Asp 
        35                  40                  45              


Cys Ala Ala Glu Xaa Pro Ala Ala Glu Pro Pro Ser Gly Lys Ile Asn 
    50                  55                  60                  


Lys Ala Ala Phe Lys Leu Phe Lys Lys Arg Lys Ser Gly Gly Xaa Met 
65                  70                  75                  80  


Pro Ser Ile Phe Gly Val Lys Asn Lys Gly Asp Gly Lys Ser Ser Gly 
                85                  90                  95      


Pro Xaa Gly Leu Val Arg Ser Arg Xaa His Asp Gly Leu Ala Glu Val 
            100                 105                 110         


Leu Val Leu Glu Ser Gly Arg Lys Glu Glu Pro Arg Gly Gly Gly Asp 
        115                 120                 125             


Ser Gly Gly Gly Gly Gly Gly Arg Pro Asn Pro Gly Pro Pro Arg Ala 
    130                 135                 140                 


Ala Gly Pro Gly Gly Gly Ser Leu Ala Ser Ser Ser Val Ala Lys Ser 
145                 150                 155                 160 


His Ser Phe Phe Ser Leu Leu Lys Lys Asn Gly Arg Ser Glu Asn Gly 
                165                 170                 175     


Lys Gly Glu Pro Val Asp Ala Ser Lys Ala Gly Gly Lys Gln Lys Arg 
            180                 185                 190         


Gly Leu Arg Gly Leu Phe Ser Gly Met Arg Trp His Arg Lys Asp Lys 
        195                 200                 205             


Arg Ala Lys Ala Glu Ala Ala Glu Gly Arg Ala Pro Gly Gly Gly Leu 
    210                 215                 220                 


Ile Leu Pro Gly Ser Leu Xaa Ala Ser Leu Glu Cys Val Lys Glu Glu 
225                 230                 235                 240 


Xaa Pro Arg Ala Ala Arg Glu Pro Glu Glu Pro Ser Gln Asp Ala Pro 
                245                 250                 255     


Arg Asp Pro Ala Gly Cys Gly Asp Ile Ile Ala Asp Gln Glu Glu Glu 
            260                 265                 270         


Ala Gly Pro Ser Cys Asp Lys His Val Pro Gly Pro Gly Lys Pro Ala 
        275                 280                 285             


Leu Ser Lys Lys Asn Pro Gly Val Val Ala Tyr Gln Gly Gly Gly Glu 
    290                 295                 300                 


Glu Met Ala Ser Pro Asp Glu Val Asp Asp Xaa Tyr Leu Gln Glu Phe 
305                 310                 315                 320 


Trp Asp Met Leu Ser Gln Xaa Glu Glu Gln Gly Pro Glu Pro Gln Glu 
                325                 330                 335     


Gly Ala Ala Lys Val Ala Ala Ala Leu Glu Xaa Lys Val Val Pro Glu 
            340                 345                 350         


Xaa Pro Lys Asp Xaa Arg Cys Val Glu Ala Ala Lys Asp Ala Ser Ser 
        355                 360                 365             


Val Lys Arg Arg Arg Leu Asn Arg Ile Pro Ile Glu Pro His Pro Lys 
    370                 375                 380                 


Glu Glu Pro Lys His Pro Glu Lys Glu Gln Gln Glu Gly Val Pro Asn 
385                 390                 395                 400 


Ser Asp Glu Gly Tyr Trp Asp Ser Xaa Xaa Pro Gly Pro Glu Glu Asp 
                405                 410                 415     


Ser Ser Ser Ser Gly Lys Lys Ala Gly Ile Pro Arg Asp Ser Tyr Ser 
            420                 425                 430         


Gly Asp Ala Leu Tyr Asp Leu Tyr Ala Asp Pro Asp Gly Ser Pro Ala 
        435                 440                 445             


Xaa Leu Pro Gly Gly Lys Asp Asn Glu Glu Xaa Ser Ser Leu Ser Arg 
    450                 455                 460                 


Leu Lys Pro Val Ser Pro Gly Xaa Ile Xaa Cys Pro Leu Arg Xaa Pro 
465                 470                 475                 480 


Gly Ser Leu Leu Lys Asp Ser Lys Ile Pro Ile Ser Ile Lys His Leu 
                485                 490                 495     


Xaa Asn Leu Pro Ser Ser His Pro Val Val His Gln Gln Pro Ser Arg 
            500                 505                 510         


Ser Glu Met Pro Arg Xaa Lys Ile Pro Val Ser Lys Val Leu Val Arg 
        515                 520                 525             


Arg Val Ser Asn Arg Gly Leu Ala Gly Xaa Xaa Ile Arg Ala Xaa Ala 
    530                 535                 540                 


Cys His Asp Ser Ala Lys Lys Leu 
545                 550         


<210> 2241
<211> 671
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<400> 2241
Met Glu Xaa Ser Arg Ser Arg Gly Gly Gly Gly Ala Val Ser Glu Arg 
1               5                   10                  15      


Gly Gly Ala Gly Ala Ser Val Gly Val Cys Arg Arg Lys Ala Glu Ala 
            20                  25                  30          


Gly Ala Gly Xaa Gly Xaa Leu Ala Ala Asp Met Asp Leu His Cys Asp 
        35                  40                  45              


Cys Ala Ala Glu Xaa Pro Ala Ala Glu Pro Pro Ser Gly Lys Ile Asn 
    50                  55                  60                  


Lys Ala Ala Phe Lys Leu Phe Lys Lys Arg Lys Ser Gly Gly Xaa Met 
65                  70                  75                  80  


Pro Ser Ile Phe Gly Val Lys Asn Lys Gly Asp Gly Lys Ser Ser Gly 
                85                  90                  95      


Pro Xaa Gly Leu Val Arg Ser Arg Xaa His Asp Gly Leu Ala Glu Val 
            100                 105                 110         


Leu Val Leu Glu Ser Gly Arg Lys Glu Glu Pro Arg Gly Gly Gly Asp 
        115                 120                 125             


Ser Gly Gly Gly Gly Gly Gly Arg Pro Asn Pro Gly Pro Pro Arg Ala 
    130                 135                 140                 


Ala Gly Pro Gly Gly Gly Ser Leu Ala Ser Ser Ser Val Ala Lys Ser 
145                 150                 155                 160 


His Ser Phe Phe Ser Leu Leu Lys Lys Asn Gly Arg Ser Glu Asn Gly 
                165                 170                 175     


Lys Gly Glu Pro Val Asp Ala Ser Lys Ala Gly Gly Lys Gln Lys Arg 
            180                 185                 190         


Gly Leu Arg Gly Leu Phe Ser Gly Met Arg Trp His Arg Lys Asp Lys 
        195                 200                 205             


Arg Ala Lys Ala Glu Ala Ala Glu Gly Arg Ala Pro Gly Gly Gly Leu 
    210                 215                 220                 


Ile Leu Pro Gly Ser Leu Xaa Ala Ser Leu Glu Cys Val Lys Glu Glu 
225                 230                 235                 240 


Xaa Pro Arg Ala Ala Arg Glu Pro Glu Glu Pro Ser Gln Asp Ala Pro 
                245                 250                 255     


Arg Asp Pro Ala Gly Glu Pro Ala Gly Gly Glu Glu Val Pro Ala Pro 
            260                 265                 270         


Ala Asp Arg Ala Pro Ala Arg Ser Cys Arg Glu Ala Glu Gly Leu Ala 
        275                 280                 285             


His Pro Gly Asp Xaa Gly Ala Arg Gly Glu Asp Ala Ala Gly His Arg 
    290                 295                 300                 


Arg Ala Glu Pro Gly Pro Gly Glu Val Arg Xaa Ala Glu Asp Ala Ser 
305                 310                 315                 320 


Arg Xaa Gly Ala Val Pro Val Lys Xaa Val Pro Leu Val Asp Ser Glu 
                325                 330                 335     


Gly Gly Ser Gly Arg Ala Pro Ala Ala Pro Asp Pro Ala Ser Val Asp 
            340                 345                 350         


Pro Pro Ser Asp Pro Ser Ala Asp Arg Ile Cys Leu Met Phe Ser Asp 
        355                 360                 365             


Val Xaa Ser Leu Lys Ser Phe Asp Ser Leu Xaa Gly Cys Gly Asp Ile 
    370                 375                 380                 


Ile Ala Asp Gln Glu Glu Glu Ala Gly Pro Ser Cys Asp Lys His Val 
385                 390                 395                 400 


Pro Gly Pro Gly Lys Pro Ala Leu Ser Lys Lys Asn Pro Gly Val Val 
                405                 410                 415     


Ala Tyr Gln Gly Gly Gly Glu Glu Met Ala Ser Pro Asp Glu Val Asp 
            420                 425                 430         


Asp Xaa Tyr Leu Gln Glu Phe Trp Asp Met Leu Ser Gln Xaa Glu Glu 
        435                 440                 445             


Gln Gly Pro Glu Pro Gln Glu Gly Ala Ala Lys Val Ala Ala Ala Leu 
    450                 455                 460                 


Glu Xaa Lys Val Val Pro Glu Xaa Pro Lys Asp Xaa Arg Cys Val Glu 
465                 470                 475                 480 


Ala Ala Lys Asp Ala Ser Ser Val Lys Arg Arg Arg Leu Asn Arg Ile 
                485                 490                 495     


Pro Ile Glu Pro His Pro Lys Glu Glu Pro Lys His Pro Glu Lys Glu 
            500                 505                 510         


Gln Gln Glu Gly Val Pro Asn Ser Asp Glu Gly Tyr Trp Asp Ser Xaa 
        515                 520                 525             


Xaa Pro Gly Pro Glu Glu Asp Ser Ser Ser Ser Gly Lys Lys Ala Gly 
    530                 535                 540                 


Ile Pro Arg Asp Ser Tyr Ser Gly Asp Ala Leu Tyr Asp Leu Tyr Ala 
545                 550                 555                 560 


Asp Pro Asp Gly Ser Pro Ala Xaa Leu Pro Gly Gly Lys Asp Asn Glu 
                565                 570                 575     


Glu Xaa Ser Ser Leu Ser Arg Leu Lys Pro Val Ser Pro Gly Xaa Ile 
            580                 585                 590         


Xaa Cys Pro Leu Arg Xaa Pro Gly Ser Leu Leu Lys Asp Ser Lys Ile 
        595                 600                 605             


Pro Ile Ser Ile Lys His Leu Xaa Asn Leu Pro Ser Ser His Pro Val 
    610                 615                 620                 


Val His Gln Gln Pro Ser Arg Ser Glu Met Pro Arg Xaa Lys Ile Pro 
625                 630                 635                 640 


Val Ser Lys Val Leu Val Arg Arg Val Ser Asn Arg Gly Leu Ala Gly 
                645                 650                 655     


Xaa Xaa Ile Arg Ala Xaa Ala Cys His Asp Ser Ala Lys Lys Leu 
            660                 665                 670     


<210> 2242
<211> 142
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<400> 2242
Met Glu Leu Lys Arg Gly Lys Xaa Phe Ile Lys Ser Ser Leu Gln Val 
1               5                   10                  15      


Ser His Glu Lys Pro Pro Asp Pro Ala Ala Val Ala Ala Ala Arg Glu 
            20                  25                  30          


Gly Xaa Gly Pro Trp Ser Val Leu Pro Gly Gly Gln Gln Arg Pro His 
        35                  40                  45              


Ser Glu Lys Gly Pro Gln Ala Ser Pro Ser Ala Gln Glu Tyr Asp Arg 
    50                  55                  60                  


Cys Pro Asn Lys Gly Ala Gln Leu Asp Pro Lys Gly Gly Pro Ala Ala 
65                  70                  75                  80  


Leu Cys Gly Ala Xaa Phe Lys Pro Val Arg Lys Cys Lys Xaa His Asp 
                85                  90                  95      


Ser Met Ser Gly Ala Gly Arg Ala Xaa Ala Ala Xaa Gly Gln Leu Val 
            100                 105                 110         


Gly Ser Ala Ser Phe Pro Gly Ser Pro Gly Ser Arg Arg Met Ile Asp 
        115                 120                 125             


Tyr Arg His Phe Val Pro Gln Met Pro Phe Val Pro Ala Val 
    130                 135                 140         


<210> 2243
<211> 180
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<400> 2243
Met Glu Leu Lys Arg Gly Lys Xaa Phe Ile Lys Ser Ser Leu Gln Val 
1               5                   10                  15      


Ser His Glu Lys Pro Pro Asp Pro Ala Ala Val Ala Ala Ala Arg Glu 
            20                  25                  30          


Gly Xaa Gly Pro Trp Ser Val Leu Pro Gly Gly Gln Gln Arg Pro His 
        35                  40                  45              


Ser Glu Lys Gly Pro Gln Ala Ser Pro Ser Ala Gln Glu Tyr Asp Arg 
    50                  55                  60                  


Cys Pro Asn Lys Gly Ala Gln Leu Asp Pro Lys Gly Gly Pro Ala Ala 
65                  70                  75                  80  


Leu Cys Gly Ala Xaa Phe Lys Pro Val Arg Lys Cys Lys Xaa His Asp 
                85                  90                  95      


Ser Met Ser Gly Ala Gly Arg Ala Xaa Ala Ala Xaa Gly Gln Leu Val 
            100                 105                 110         


Gly Ser Ala Ser Phe Pro Gly Ser Pro Gly Ser Arg Arg Met Ile Asp 
        115                 120                 125             


Tyr Arg His Phe Val Pro Gln Met Pro Phe Val Pro Ala Val Ala Lys 
    130                 135                 140                 


Ser Ile Pro Arg Lys Arg Ile Ser Leu Lys Arg Pro Lys Lys Cys Phe 
145                 150                 155                 160 


Arg Asn Leu Phe His Ile Arg Arg Asn Lys Xaa Glu Asp Leu Ala Ser 
                165                 170                 175     


Leu Ala Ala Glu 
            180 


<210> 2244
<211> 861
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<400> 2244
Met Glu Leu Lys Arg Gly Lys Xaa Phe Ile Lys Ser Ser Leu Gln Val 
1               5                   10                  15      


Ser His Glu Lys Pro Pro Asp Pro Ala Ala Val Ala Ala Ala Arg Glu 
            20                  25                  30          


Gly Xaa Gly Pro Trp Ser Val Leu Pro Gly Gly Gln Gln Arg Pro His 
        35                  40                  45              


Ser Glu Lys Gly Pro Gln Ala Ser Pro Ser Ala Gln Glu Tyr Asp Arg 
    50                  55                  60                  


Cys Pro Asn Lys Gly Ala Gln Leu Asp Pro Lys Gly Gly Pro Ala Ala 
65                  70                  75                  80  


Leu Cys Gly Ala Xaa Phe Lys Pro Val Arg Lys Cys Lys Xaa His Asp 
                85                  90                  95      


Ser Met Ser Gly Ala Gly Arg Ala Xaa Ala Ala Xaa Gly Gln Leu Val 
            100                 105                 110         


Gly Ser Ala Ser Phe Pro Gly Ser Pro Gly Ser Arg Arg Met Ile Asp 
        115                 120                 125             


Tyr Arg His Phe Val Pro Gln Met Pro Phe Val Pro Ala Val Ala Lys 
    130                 135                 140                 


Ser Ile Pro Arg Lys Arg Ile Ser Leu Lys Arg Pro Lys Lys Cys Phe 
145                 150                 155                 160 


Arg Asn Leu Phe His Ile Arg Arg Asn Lys Xaa Glu Asp Leu Ala Ser 
                165                 170                 175     


Leu Ala Ala Glu Gly Lys Ser Leu Pro Ser Pro Gly Asp Pro Ser Asp 
            180                 185                 190         


Pro Gly Gly Arg Arg Ser Lys Ala Phe Leu Pro Pro Gly Glu Gly Pro 
        195                 200                 205             


Gly Leu Asp Gly Leu Cys Gln Asp Leu Leu Asp Ser Glu Leu Leu Ala 
    210                 215                 220                 


Asp Ala Ser Phe Gly Leu Cys Arg Ala Leu Cys Glu Asp Val Ala Ser 
225                 230                 235                 240 


Leu Gln Ser Phe Asp Ser Leu Xaa Gly Cys Gly Glu Val Phe Ala Asp 
                245                 250                 255     


Glu Ser Ser Val Pro Ser Leu Glu Leu Asn Glu Gly Pro Glu Ser Pro 
            260                 265                 270         


Xaa Gln Ala Ala Gln Gly Leu Glu Ser Lys Val Pro Arg Gly Pro Leu 
        275                 280                 285             


Gln Gly Ser Val Glu Gln Leu Ala Ser Pro Ala Gln Asn Glu Ala Ser 
    290                 295                 300                 


Asp Phe Xaa Arg Phe Trp Asp Ser Val Asn Arg Ser Val Arg Gln Gln 
305                 310                 315                 320 


Gln Arg Ala Leu Leu Gly Pro Trp Leu Ser Gly Pro Gln Gly Xaa Asp 
                325                 330                 335     


Arg Asp Gln Ser Arg Leu Asp Xaa Ala Gly Leu Ala Glu Leu Pro Leu 
            340                 345                 350         


Cys Pro Cys Arg Asp Pro Arg Ser Gly Ser Lys Ala Ser Ser Ile Asp 
        355                 360                 365             


Xaa Gly Xaa Pro Lys Ser Glu Gln Pro Glu Ser Val Ser Xaa Ser Asp 
    370                 375                 380                 


Glu Gly Tyr Tyr Asp Ser Phe Ser Pro Gly Leu Glu Glu Asp Lys Lys 
385                 390                 395                 400 


Glu Ala Glu Ser Pro Gly Xaa Pro Ala Ala Xaa Phe Pro Arg Asp Ser 
                405                 410                 415     


Tyr Ser Gly Asp Ala Leu Tyr Glu Leu Phe His Asp Pro Ser Glu Gly 
            420                 425                 430         


Pro Leu Gly Pro Ser Pro Asp Asp Asp Leu Cys Val Ser Glu Ser Leu 
        435                 440                 445             


Ser Gly Pro Ala Leu Gly Xaa Pro Leu Ser Ile Cys Ser Phe Arg Val 
    450                 455                 460                 


Gly Ala Glu Glu Asn Leu Ala Pro Ala Pro Gly Pro Asp Leu Leu Ser 
465                 470                 475                 480 


Gln Gly Phe Leu Gln Ser Ser Trp Lys Gly Lys Glu Cys Leu Leu Lys 
                485                 490                 495     


Leu Cys Asp Xaa Glu Leu Ala Ile Xaa Met Gly Ile Val Ser Trp Leu 
            500                 505                 510         


Arg Arg Gly Pro Xaa Pro Arg Ala Pro Pro Xaa Pro Gly Gln Pro Ala 
        515                 520                 525             


Ala Pro Pro Gly Ser Gln Gly Ala Pro Arg Ala Pro Xaa Glu Lys Leu 
    530                 535                 540                 


Gly Gly Arg Glu Gly Leu Ala Ser Asp Ala Gly Gly Ala Xaa Val Cys 
545                 550                 555                 560 


Ser Ala Pro Ser Arg Gln Glu Leu Trp Ala His Pro Gly Xaa Xaa Gly 
                565                 570                 575     


Leu Leu Ala Gly Glu Ser Lys Ala Leu Gly Gly Ala Xaa Gln Gly Xaa 
            580                 585                 590         


Gly Xaa Leu Ser Arg Asp Ala Ser Arg Glu Glu Glu Xaa Arg Gly His 
        595                 600                 605             


Ser Glu Gly Leu Phe Ser Ser Met Glu Ser Ala Ala Xaa Ser Xaa Xaa 
    610                 615                 620                 


Asp Xaa Ser Gly Lys Asn Lys Ala Pro Val Pro Ser Xaa Trp Pro Cys 
625                 630                 635                 640 


Ser Gln Lys Glu Pro Gly Pro Pro Gly Val Leu Gly Cys Phe Arg Gly 
                645                 650                 655     


Pro Trp Arg Pro Gly His Gly Gly Asp Xaa Leu Asp Ala Glu Pro Met 
            660                 665                 670         


Leu Ala Gly Cys Val Ala Arg Val Ala Ala Leu Lys Ile Ser Ser Asn 
        675                 680                 685             


Glu Gln Pro Pro Ala Ala Trp Pro Pro Arg Gln Asp Met Gly Ser Gly 
    690                 695                 700                 


Leu Phe Gly Gln Arg Trp Ala Arg Gly Pro Asp Met Leu Glu Gln Lys 
705                 710                 715                 720 


Gln Ser Ser Ser Ser Pro Ser Met Xaa Xaa Ile His Gly Leu Pro Tyr 
                725                 730                 735     


Ser Ala Ser Xaa Gln Asp Gln Arg Cys Arg Asp Arg Val Gln Asp Leu 
            740                 745                 750         


Ser Trp Leu Arg Val Glu Pro Xaa Gly Leu Gly Val Gln Ala Trp Ala 
        755                 760                 765             


Ser Val Glu Asp Gln Pro Leu Gln Leu Ser Xaa Glu Ala Val Glu Gln 
    770                 775                 780                 


Val Ala His Gly Ser Gln Leu Asp Ser Glu Pro Arg Ser Ala Pro Ala 
785                 790                 795                 800 


Ala Arg Trp Ser Ser Gln Gly His His Pro Glu Ser Leu Gly Leu Xaa 
                805                 810                 815     


Leu Asn Ser Gln Gln Glu Gly Gly Val Ser Ala Ser Ala Pro Glu Cys 
            820                 825                 830         


Arg Cys Ser Leu Leu Ala Arg Glu Gly Leu Leu Cys Gly Gln Pro Glu 
        835                 840                 845             


Val Gly Ala Ser Gly Pro Ala Met Ala Glu Pro His Leu 
    850                 855                 860     


<210> 2245
<211> 165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 2245
Met Leu Val Ala Lys Leu Ile Gln Cys Ile Val Phe Gly Pro Leu Arg 
1               5                   10                  15      


Val Ser Glu Arg Gln His Leu Lys Asp Lys Phe Trp Asn Phe Ile Phe 
            20                  25                  30          


Tyr Lys Phe Ile Phe Ile Phe Gly Val Leu Asn Val Gln Xaa Val Glu 
        35                  40                  45              


Glu Val Val Met Trp Cys Leu Trp Phe Ala Gly Leu Val Phe Leu His 
    50                  55                  60                  


Leu Met Val Gln Leu Cys Lys Asp Arg Phe Glu Tyr Leu Ser Phe Ser 
65                  70                  75                  80  


Pro Xaa Xaa Pro Met Ser Ser His Gly Arg Val Leu Ser Leu Leu Val 
                85                  90                  95      


Ala Met Leu Leu Ser Cys Cys Gly Leu Ala Ala Val Cys Ser Ile Xaa 
            100                 105                 110         


Gly Tyr Xaa His Gly Met His Xaa Leu Ala Phe Met Ala Ala Glu Ser 
        115                 120                 125             


Leu Leu Val Xaa Val Arg Xaa Ala His Val Ile Leu Arg Tyr Val Ile 
    130                 135                 140                 


His Leu Trp Asp Leu Asn His Glu Gly Xaa Trp Glu Gly Lys Gly Xaa 
145                 150                 155                 160 


Tyr Val Tyr Tyr Xaa 
                165 


<210> 2246
<211> 229
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<400> 2246
Met Leu Val Ala Lys Leu Ile Gln Cys Ile Val Phe Gly Pro Leu Arg 
1               5                   10                  15      


Val Ser Glu Arg Gln His Leu Lys Asp Lys Phe Trp Asn Phe Ile Phe 
            20                  25                  30          


Tyr Lys Phe Ile Phe Ile Phe Gly Val Leu Asn Val Gln Xaa Val Glu 
        35                  40                  45              


Glu Val Val Met Trp Cys Leu Trp Phe Ala Gly Leu Val Phe Leu His 
    50                  55                  60                  


Leu Met Val Gln Leu Cys Lys Asp Arg Phe Glu Tyr Leu Ser Phe Ser 
65                  70                  75                  80  


Pro Xaa Xaa Pro Met Ser Ser His Gly Arg Val Leu Ser Leu Leu Val 
                85                  90                  95      


Ala Met Leu Leu Ser Cys Cys Gly Leu Ala Ala Val Cys Ser Ile Xaa 
            100                 105                 110         


Gly Tyr Xaa His Gly Met His Xaa Leu Ala Phe Met Ala Ala Glu Ser 
        115                 120                 125             


Leu Leu Val Xaa Val Arg Xaa Ala His Val Ile Leu Arg Tyr Val Ile 
    130                 135                 140                 


His Leu Trp Asp Leu Asn His Glu Gly Xaa Trp Glu Gly Lys Gly Xaa 
145                 150                 155                 160 


Tyr Val Tyr Tyr Xaa Asp Phe Val Met Glu Leu Xaa Leu Leu Ser Leu 
                165                 170                 175     


Asp Leu Met His His Ile His Met Leu Leu Phe Gly Asn Ile Trp Leu 
            180                 185                 190         


Ser Met Ala Ser Leu Val Ile Phe Met Gln Leu Arg Tyr Leu Phe His 
        195                 200                 205             


Glu Val Gln Arg Arg Ile Arg Arg His Lys Asn Tyr Leu Arg Val Val 
    210                 215                 220                 


Gly Asn Met Glu Ala 
225                 


<210> 2247
<211> 643
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<400> 2247
Met Pro Leu Leu Phe Leu Glu Arg Phe Pro Trp Pro Ser Leu Arg Xaa 
1               5                   10                  15      


Tyr Xaa Gly Leu Ser Gly Leu Ala Leu Leu Gly Xaa Ile Ile Ser Ala 
            20                  25                  30          


Tyr Arg Ala Leu Ser Gln Pro Glu Ala Gly Pro Gly Glu Pro Asp Gln 
        35                  40                  45              


Leu Xaa Ala Ser Leu Gln Pro Glu Pro Pro Ala Pro Ala Arg Pro Ser 
    50                  55                  60                  


Ala Gly Gly Pro Arg Ala Arg Asp Val Ala Gln Tyr Leu Leu Ser Asp 
65                  70                  75                  80  


Ser Leu Phe Val Trp Val Leu Val Asn Xaa Ala Cys Cys Val Leu Met 
                85                  90                  95      


Leu Val Ala Lys Leu Ile Gln Cys Ile Val Phe Gly Pro Leu Arg Val 
            100                 105                 110         


Ser Glu Arg Gln His Leu Lys Asp Lys Phe Trp Asn Phe Ile Phe Tyr 
        115                 120                 125             


Lys Phe Ile Phe Ile Phe Gly Val Leu Asn Val Gln Xaa Val Glu Glu 
    130                 135                 140                 


Val Val Met Trp Cys Leu Trp Phe Ala Gly Leu Val Phe Leu His Leu 
145                 150                 155                 160 


Met Val Gln Leu Cys Lys Asp Arg Phe Glu Tyr Leu Ser Phe Ser Pro 
                165                 170                 175     


Xaa Xaa Pro Met Ser Ser His Gly Arg Val Leu Ser Leu Leu Val Ala 
            180                 185                 190         


Met Leu Leu Ser Cys Cys Gly Leu Ala Ala Val Cys Ser Ile Xaa Gly 
        195                 200                 205             


Tyr Xaa His Gly Met His Xaa Leu Ala Phe Met Ala Ala Glu Ser Leu 
    210                 215                 220                 


Leu Val Xaa Val Arg Xaa Ala His Val Ile Leu Arg Tyr Val Ile His 
225                 230                 235                 240 


Leu Trp Asp Leu Asn His Glu Gly Xaa Trp Glu Gly Lys Gly Xaa Tyr 
                245                 250                 255     


Val Tyr Tyr Xaa Asp Phe Val Met Glu Leu Xaa Leu Leu Ser Leu Asp 
            260                 265                 270         


Leu Met His His Ile His Met Leu Leu Phe Gly Asn Ile Trp Leu Ser 
        275                 280                 285             


Met Ala Ser Leu Val Ile Phe Met Gln Leu Arg Tyr Leu Phe His Glu 
    290                 295                 300                 


Val Gln Arg Arg Ile Arg Arg His Lys Asn Tyr Leu Arg Val Val Gly 
305                 310                 315                 320 


Asn Met Glu Ala Arg Phe Ala Val Ala Xaa Pro Glu Glu Leu Ala Val 
                325                 330                 335     


Asn Asn Asp Asp Cys Ala Ile Cys Trp Asp Ser Met Gln Ala Ala Arg 
            340                 345                 350         


Lys Leu Pro Cys Gly His Leu Phe His Asn Ser Cys Leu Arg Ser Trp 
        355                 360                 365             


Leu Glu Gln Asp Xaa Ser Cys Pro Xaa Cys Arg Met Ser Leu Asn Ile 
    370                 375                 380                 


Ala Asp Asn Asn Arg Val Arg Glu Glu His Gln Gly Glu Asn Leu Asp 
385                 390                 395                 400 


Glu Asn Leu Val Pro Val Ala Ala Ala Glu Gly Arg Pro Arg Leu Asn 
                405                 410                 415     


Gln His Asn His Phe Phe His Phe Asp Gly Ser Arg Ile Ala Ser Trp 
            420                 425                 430         


Leu Pro Ser Phe Ser Val Glu Val Met His Xaa Xaa Asn Ile Leu Gly 
        435                 440                 445             


Ile Xaa Gln Ala Ser Asn Ser Gln Leu Asn Ala Met Ala His Gln Ile 
    450                 455                 460                 


Gln Glu Met Phe Pro Gln Val Pro Tyr His Leu Val Leu Gln Asp Leu 
465                 470                 475                 480 


Gln Leu Xaa Arg Ser Val Glu Ile Xaa Xaa Asp Asn Ile Leu Glu Gly 
                485                 490                 495     


Arg Ile Gln Val Pro Phe Pro Xaa Gln Arg Ser Asp Ser Ile Arg Pro 
            500                 505                 510         


Ala Leu Asn Ser Pro Val Glu Arg Pro Ser Ser Asp Gln Glu Glu Gly 
        515                 520                 525             


Glu Xaa Ser Ala Gln Xaa Glu Arg Val Pro Leu Asp Leu Ser Pro Arg 
    530                 535                 540                 


Leu Glu Glu Xaa Leu Asp Phe Gly Glu Val Glu Val Glu Pro Ser Glu 
545                 550                 555                 560 


Val Glu Asp Phe Glu Ala Arg Gly Ser Arg Phe Ser Lys Ser Ala Asp 
                565                 570                 575     


Glu Arg Gln Arg Met Leu Val Gln Arg Lys Asp Glu Leu Leu Gln Gln 
            580                 585                 590         


Ala Arg Lys Arg Phe Leu Asn Lys Ser Ser Glu Asp Asp Ala Ala Ser 
        595                 600                 605             


Glu Ser Phe Leu Pro Ser Glu Gly Ala Ser Ser Asp Pro Val Xaa Leu 
    610                 615                 620                 


Arg Arg Arg Met Leu Ala Ala Ala Ala Glu Arg Arg Leu Gln Lys Gln 
625                 630                 635                 640 


Gln Xaa Ser 
            


<210> 2248
<211> 288
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<400> 2248
Trp Leu Ser Met Ala Ser Leu Val Ile Phe Met Gln Leu Arg Tyr Leu 
1               5                   10                  15      


Phe His Glu Val Gln Arg Arg Ile Arg Arg His Lys Asn Tyr Leu Arg 
            20                  25                  30          


Val Val Gly Asn Met Glu Ala Arg Phe Ala Val Ala Xaa Pro Glu Glu 
        35                  40                  45              


Leu Ala Val Asn Asn Asp Asp Cys Ala Ile Cys Trp Asp Ser Met Gln 
    50                  55                  60                  


Ala Ala Arg Lys Leu Pro Cys Gly His Leu Phe His Asn Ser Cys Leu 
65                  70                  75                  80  


Arg Ser Trp Leu Glu Gln Asp Xaa Ser Cys Pro Xaa Cys Arg Met Ser 
                85                  90                  95      


Leu Asn Ile Ala Asp Asn Asn Arg Val Arg Glu Glu His Gln Gly Glu 
            100                 105                 110         


Asn Leu Asp Glu Asn Leu Val Pro Val Ala Ala Ala Glu Gly Arg Pro 
        115                 120                 125             


Arg Leu Asn Gln His Asn His Phe Phe His Phe Asp Gly Asp Asp Ser 
    130                 135                 140                 


Ser Met Arg Val Xaa Ala Pro Glu Asp Val Pro Val Gly Gln Glu Val 
145                 150                 155                 160 


Glu Val Val Asp Ser Asp Xaa Asp Ala Pro Asp Leu Trp Ser Arg Ile 
                165                 170                 175     


Ala Ser Trp Leu Pro Ser Phe Ser Val Glu Val Met His Xaa Xaa Asn 
            180                 185                 190         


Ile Leu Gly Ile Xaa Gln Ala Ser Asn Ser Gln Leu Asn Ala Met Ala 
        195                 200                 205             


His Gln Ile Gln Glu Met Phe Pro Gln Val Pro Tyr His Leu Val Leu 
    210                 215                 220                 


Gln Asp Leu Gln Leu Xaa Arg Ser Val Glu Ile Xaa Xaa Asp Asn Ile 
225                 230                 235                 240 


Leu Glu Gly Arg Ile Gln Val Pro Phe Pro Xaa Gln Arg Ser Asp Ser 
                245                 250                 255     


Ile Arg Pro Ala Leu Asn Ser Pro Val Glu Arg Pro Ser Ser Asp Gln 
            260                 265                 270         


Glu Glu Gly Glu Xaa Ser Ala Gln Xaa Glu Arg Val Pro Leu Asp Leu 
        275                 280                 285             


<210> 2249
<211> 299
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<400> 2249
Tyr Leu Ala Xaa Ser Gly Tyr Pro Trp Pro Ala Trp Ser Ser Leu Cys 
1               5                   10                  15      


Ser Cys Val Xaa Cys Phe Met Arg Cys Asn Val Glu Phe Val Gly Xaa 
            20                  25                  30          


Arg Xaa Ile Tyr Val Trp Leu Glu Xaa Trp Arg Pro Gly Leu Gln Leu 
        35                  40                  45              


Gln Leu Gln Arg Ser Trp Leu Ser Xaa Met Xaa Xaa Val Pro Ser Val 
    50                  55                  60                  


Gly Xaa Pro Cys Arg Leu Arg Gly Asn Cys Pro Val Asp Ile Phe Ser 
65                  70                  75                  80  


Xaa Arg Ser Arg Ile Ala Ser Trp Leu Pro Ser Phe Ser Val Glu Val 
                85                  90                  95      


Met His Xaa Xaa Asn Ile Leu Gly Ile Xaa Gln Ala Ser Asn Ser Gln 
            100                 105                 110         


Leu Asn Ala Met Ala His Gln Ile Gln Glu Met Phe Pro Gln Val Pro 
        115                 120                 125             


Tyr His Leu Val Leu Gln Asp Leu Gln Leu Xaa Arg Ser Val Glu Ile 
    130                 135                 140                 


Xaa Xaa Asp Asn Ile Leu Glu Gly Arg Ile Gln Val Pro Phe Pro Xaa 
145                 150                 155                 160 


Gln Arg Ser Asp Ser Ile Arg Pro Ala Leu Asn Ser Pro Val Glu Arg 
                165                 170                 175     


Pro Ser Ser Asp Gln Glu Glu Gly Glu Xaa Ser Ala Gln Xaa Glu Arg 
            180                 185                 190         


Val Pro Leu Asp Leu Ser Pro Arg Leu Glu Glu Xaa Leu Asp Phe Gly 
        195                 200                 205             


Glu Val Glu Val Glu Pro Ser Glu Val Glu Asp Phe Glu Ala Arg Gly 
    210                 215                 220                 


Ser Arg Phe Ser Lys Ser Ala Asp Glu Arg Gln Arg Met Leu Val Gln 
225                 230                 235                 240 


Arg Lys Asp Glu Leu Leu Gln Gln Ala Arg Lys Arg Phe Leu Asn Lys 
                245                 250                 255     


Ser Ser Glu Asp Asp Ala Ala Ser Glu Ser Phe Leu Pro Ser Glu Gly 
            260                 265                 270         


Ala Ser Ser Asp Pro Val Xaa Leu Arg Arg Arg Met Leu Ala Ala Ala 
        275                 280                 285             


Ala Glu Arg Arg Leu Gln Lys Gln Gln Xaa Ser 
    290                 295                 


<210> 2250
<211> 560
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<400> 2250
Met Arg Asp Leu Pro Leu Xaa Ser Leu Ala Leu Val Leu Ser Ala Leu 
1               5                   10                  15      


Gly Ala Leu Leu Gly Xaa Glu Ala Leu Arg Ala Glu Glu Pro Ala Val 
            20                  25                  30          


Gly Xaa Ser Gly Leu Ile Phe Arg Glu Asp Leu Asp Trp Pro Pro Gly 
        35                  40                  45              


Ser Pro Gln Glu Pro Leu Cys Leu Val Ala Leu Gly Gly Asp Ser Asn 
    50                  55                  60                  


Gly Ser Ser Ser Pro Leu Arg Val Val Gly Ala Leu Ser Ala Tyr Glu 
65                  70                  75                  80  


Gln Ala Phe Leu Gly Ala Val Gln Arg Ala Arg Trp Gly Pro Arg Asp 
                85                  90                  95      


Leu Ala Xaa Phe Gly Val Cys Asn Xaa Gly Asp Arg Gln Ala Ala Leu 
            100                 105                 110         


Pro Ser Leu Arg Arg Leu Gly Ala Trp Leu Arg Asp Pro Gly Gly Gln 
        115                 120                 125             


Arg Leu Val Val Leu His Leu Glu Glu Val Xaa Trp Glu Pro Xaa Pro 
    130                 135                 140                 


Ser Leu Arg Phe Gln Glu Pro Pro Pro Gly Gly Ala Gly Pro Pro Glu 
145                 150                 155                 160 


Leu Ala Leu Leu Val Leu Tyr Pro Gly Pro Gly Pro Glu Val Xaa Val 
                165                 170                 175     


Xaa Arg Ala Gly Leu Pro Gly Ala Gln Ser Leu Cys Pro Ser Arg Asp 
            180                 185                 190         


Xaa Arg Tyr Leu Val Leu Ala Val Asp Arg Pro Ala Gly Ala Trp Arg 
        195                 200                 205             


Gly Ser Gly Leu Ala Leu Xaa Leu Gln Pro Arg Gly Glu Asp Ser Arg 
    210                 215                 220                 


Leu Ser Xaa Ala Arg Leu Gln Ala Leu Leu Phe Gly Asp Asp His Arg 
225                 230                 235                 240 


Cys Phe Xaa Arg Met Xaa Pro Ala Leu Leu Leu Leu Pro Arg Ser Glu 
                245                 250                 255     


Pro Ala Pro Leu Pro Ala His Gly Gln Leu Asp Xaa Val Pro Phe Pro 
            260                 265                 270         


Pro Pro Arg Pro Ser Ala Glu Leu Glu Glu Ser Pro Pro Ser Ala Asp 
        275                 280                 285             


Pro Phe Leu Glu Xaa Leu Xaa Arg Leu Val Arg Ala Leu Arg Val Pro 
    290                 295                 300                 


Pro Ala Arg Ala Ser Ala Pro Arg Leu Ala Leu Asp Pro Asp Ala Leu 
305                 310                 315                 320 


Ala Gly Phe Pro Gln Gly Leu Val Asn Leu Ser Asp Pro Ala Ala Leu 
                325                 330                 335     


Glu Arg Leu Leu Asp Gly Glu Glu Pro Leu Leu Leu Leu Leu Arg Pro 
            340                 345                 350         


Xaa Ala Ala Xaa Xaa Gly Asp Pro Ala Pro Leu His Asp Pro Xaa Ser 
        355                 360                 365             


Ala Pro Trp Ala Xaa Ala Leu Ala Arg Arg Val Ala Ala Glu Leu Gln 
    370                 375                 380                 


Ala Ala Ala Ala Glu Leu Arg Ser Leu Pro Gly Leu Pro Pro Ala Xaa 
385                 390                 395                 400 


Ala Pro Leu Leu Ala Arg Leu Leu Ala Leu Cys Pro Gly Gly Pro Gly 
                405                 410                 415     


Gly Leu Gly Asp Pro Leu Arg Ala Leu Leu Leu Leu Lys Ala Leu Gln 
            420                 425                 430         


Gly Leu Arg Val Glu Trp Arg Gly Arg Asp Pro Arg Gly Pro Gly Arg 
        435                 440                 445             


Ala Gln Arg Ser Ala Gly Ala Xaa Ala Ala Asp Gly Pro Cys Ala Leu 
    450                 455                 460                 


Arg Glu Leu Ser Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro 
465                 470                 475                 480 


Glu Xaa Tyr Gln Ala Asn Asn Cys Gln Gly Val Cys Gly Trp Pro Gln 
                485                 490                 495     


Ser Asp Arg Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys 
            500                 505                 510         


Met Gln Val Arg Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro 
        515                 520                 525             


Xaa Ala Tyr Ala Gly Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile 
    530                 535                 540                 


Ser Ala His His Val Pro Asn Met Val Ala Xaa Glu Cys Gly Cys Arg 
545                 550                 555                 560 


<210> 2251
<211> 172
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<400> 2251
Met Ala Leu Ser Leu Ala Gln Gly Leu Ala Phe Leu His Glu Glu Arg 
1               5                   10                  15      


Trp Gln Asn Gly Gln Tyr Lys Pro Gly Ile Ala His Arg Asp Leu Ser 
            20                  25                  30          


Ser Gln Asn Val Leu Ile Arg Glu Asp Gly Ser Cys Ala Ile Gly Asp 
        35                  40                  45              


Leu Gly Leu Ala Leu Val Leu Pro Gly Leu Xaa Gln Pro Pro Ala Trp 
    50                  55                  60                  


Xaa Pro Xaa Gln Pro Gln Gly Pro Ala Ala Ile Met Glu Ala Gly Xaa 
65                  70                  75                  80  


Gln Arg Tyr Met Ala Pro Glu Leu Leu Asp Lys Xaa Leu Asp Leu Gln 
                85                  90                  95      


Asp Trp Gly Met Ala Leu Arg Arg Ala Asp Ile Tyr Ser Leu Ala Leu 
            100                 105                 110         


Leu Leu Trp Glu Ile Leu Ser Arg Cys Pro Asp Leu Arg Pro Asp Ser 
        115                 120                 125             


Ser Pro Pro Pro Phe Gln Leu Ala Tyr Glu Ala Glu Leu Gly Asn Xaa 
    130                 135                 140                 


Pro Xaa Ser Asp Glu Leu Trp Ala Leu Ala Val Gln Glu Arg Arg Arg 
145                 150                 155                 160 


Pro Tyr Ile Pro Ser Xaa Trp Arg Cys Phe Ala Xaa 
                165                 170         


<210> 2252
<211> 478
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<400> 2252
Met Leu Gly Ser Leu Gly Leu Trp Ala Leu Leu Pro Xaa Ala Val Glu 
1               5                   10                  15      


Ala Pro Pro Asn Arg Arg Xaa Cys Val Phe Phe Glu Ala Pro Gly Val 
            20                  25                  30          


Arg Gly Ser Xaa Lys Xaa Leu Gly Glu Leu Leu Asp Xaa Gly Xaa Glu 
        35                  40                  45              


Leu Pro Arg Ala Ile Arg Cys Leu Tyr Ser Arg Cys Cys Phe Gly Ile 
    50                  55                  60                  


Trp Asn Leu Xaa Gln Asp Arg Ala Gln Val Glu Met Gln Gly Cys Arg 
65                  70                  75                  80  


Asp Ser Asp Glu Pro Gly Cys Glu Ser Leu His Cys Asp Pro Ser Pro 
                85                  90                  95      


Arg Ala His Pro Ser Pro Gly Ser Xaa Leu Phe Xaa Cys Ser Cys Gly 
            100                 105                 110         


Xaa Asp Phe Cys Asn Ala Asn Tyr Ser His Leu Pro Pro Pro Gly Ser 
        115                 120                 125             


Pro Gly Xaa Pro Gly Ser Gln Gly Pro Gln Ala Ala Pro Gly Glu Ser 
    130                 135                 140                 


Ile Trp Met Ala Leu Val Leu Leu Gly Leu Phe Leu Leu Leu Leu Leu 
145                 150                 155                 160 


Leu Leu Gly Ser Ile Ile Leu Ala Leu Leu Gln Arg Lys Asn Tyr Arg 
                165                 170                 175     


Val Arg Gly Glu Pro Val Pro Glu Pro Arg Pro Asp Ser Gly Arg Asp 
            180                 185                 190         


Trp Ser Val Glu Leu Gln Glu Leu Pro Glu Leu Cys Phe Ser Gln Val 
        195                 200                 205             


Ile Arg Glu Gly Gly His Ala Val Val Trp Ala Gly Gln Leu Gln Gly 
    210                 215                 220                 


Lys Leu Val Ala Ile Lys Ala Phe Pro Pro Arg Ser Val Ala Gln Phe 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Leu Tyr Glu Leu Pro Gly Leu Gln His Asp His 
                245                 250                 255     


Ile Val Arg Phe Ile Xaa Ala Ser Arg Gly Gly Pro Gly Arg Leu Leu 
            260                 265                 270         


Ser Gly Pro Leu Leu Val Leu Glu Leu His Pro Lys Gly Ser Leu Cys 
        275                 280                 285             


His Tyr Leu Xaa Gln Tyr Xaa Ser Asp Trp Gly Ser Ser Leu Arg Met 
    290                 295                 300                 


Ala Leu Ser Leu Ala Gln Gly Leu Ala Phe Leu His Glu Glu Arg Trp 
305                 310                 315                 320 


Gln Asn Gly Gln Tyr Lys Pro Gly Ile Ala His Arg Asp Leu Ser Ser 
                325                 330                 335     


Gln Asn Val Leu Ile Arg Glu Asp Gly Ser Cys Ala Ile Gly Asp Leu 
            340                 345                 350         


Gly Leu Ala Leu Val Leu Pro Gly Leu Xaa Gln Pro Pro Ala Trp Xaa 
        355                 360                 365             


Pro Xaa Gln Pro Gln Gly Pro Ala Ala Ile Met Glu Asp Pro Asp Gly 
    370                 375                 380                 


Leu Arg Glu Leu Leu Glu Asp Cys Trp Asp Ala Asp Pro Glu Ala Arg 
385                 390                 395                 400 


Leu Xaa Ala Glu Cys Val Gln Gln Arg Leu Ala Ala Leu Ala His Pro 
                405                 410                 415     


Gln Glu Ser His Pro Phe Pro Glu Ser Cys Pro Arg Gly Cys Pro Pro 
            420                 425                 430         


Leu Cys Pro Glu Asp Cys Xaa Ser Ile Pro Ala Pro Xaa Ile Leu Pro 
        435                 440                 445             


Cys Arg Pro Gln Arg Ser Ala Cys His Phe Ser Val Gln Gln Gly Pro 
    450                 455                 460                 


Cys Ser Arg Asn Pro Gln Pro Ala Cys Xaa Leu Ser Pro Val 
465                 470                 475             


<210> 2253
<211> 478
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<400> 2253
Met Leu Gly Ser Leu Gly Leu Trp Ala Leu Leu Pro Xaa Ala Val Glu 
1               5                   10                  15      


Ala Pro Pro Asn Arg Arg Xaa Cys Val Phe Phe Glu Ala Pro Gly Val 
            20                  25                  30          


Arg Gly Ser Xaa Lys Xaa Leu Gly Glu Leu Leu Asp Xaa Gly Xaa Glu 
        35                  40                  45              


Leu Pro Arg Ala Ile Arg Cys Leu Tyr Ser Arg Cys Cys Phe Gly Ile 
    50                  55                  60                  


Trp Asn Leu Xaa Gln Asp Arg Ala Gln Val Glu Met Gln Gly Cys Arg 
65                  70                  75                  80  


Asp Ser Asp Glu Pro Gly Cys Glu Ser Leu His Cys Asp Pro Ser Pro 
                85                  90                  95      


Arg Ala His Pro Ser Pro Gly Ser Xaa Leu Phe Xaa Cys Ser Cys Gly 
            100                 105                 110         


Xaa Asp Phe Cys Asn Ala Asn Tyr Ser His Leu Pro Pro Pro Gly Ser 
        115                 120                 125             


Pro Gly Xaa Pro Gly Ser Gln Gly Pro Gln Ala Ala Pro Gly Glu Ser 
    130                 135                 140                 


Ile Trp Met Ala Leu Val Leu Leu Gly Leu Phe Leu Leu Leu Leu Leu 
145                 150                 155                 160 


Leu Leu Gly Ser Ile Ile Leu Ala Leu Leu Gln Arg Lys Asn Tyr Arg 
                165                 170                 175     


Val Arg Gly Glu Pro Val Pro Glu Pro Arg Pro Asp Ser Gly Arg Asp 
            180                 185                 190         


Trp Ser Val Glu Leu Gln Glu Leu Pro Glu Leu Cys Phe Ser Gln Val 
        195                 200                 205             


Ile Arg Glu Gly Gly His Ala Val Val Trp Ala Gly Gln Leu Gln Gly 
    210                 215                 220                 


Lys Leu Val Ala Ile Lys Ala Phe Pro Pro Arg Ser Val Ala Gln Phe 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Leu Tyr Glu Leu Pro Gly Leu Gln His Asp His 
                245                 250                 255     


Ile Val Arg Phe Ile Xaa Ala Ser Arg Gly Gly Pro Gly Arg Leu Leu 
            260                 265                 270         


Ser Gly Pro Leu Leu Val Leu Glu Leu His Pro Lys Gly Ser Leu Cys 
        275                 280                 285             


His Tyr Leu Xaa Gln Tyr Xaa Ser Asp Trp Gly Ser Ser Leu Arg Met 
    290                 295                 300                 


Ala Leu Ser Leu Ala Gln Gly Leu Ala Phe Leu His Glu Glu Arg Trp 
305                 310                 315                 320 


Gln Asn Gly Gln Tyr Lys Pro Gly Ile Ala His Arg Asp Leu Ser Ser 
                325                 330                 335     


Gln Asn Val Leu Ile Arg Glu Asp Gly Ser Cys Ala Ile Gly Asp Leu 
            340                 345                 350         


Gly Leu Ala Leu Val Leu Pro Gly Leu Xaa Gln Pro Pro Ala Trp Xaa 
        355                 360                 365             


Pro Xaa Gln Pro Gln Gly Pro Ala Ala Ile Met Glu Ala Gly Xaa Gln 
    370                 375                 380                 


Arg Tyr Met Ala Pro Glu Leu Leu Asp Lys Xaa Leu Asp Leu Gln Asp 
385                 390                 395                 400 


Trp Gly Met Ala Leu Arg Arg Ala Asp Ile Tyr Ser Leu Ala Leu Leu 
                405                 410                 415     


Leu Trp Glu Ile Leu Ser Arg Cys Pro Asp Leu Arg Pro Ala Val His 
            420                 425                 430         


His Pro Ser Asn Trp Pro Met Arg Gln Asn Trp Ala Ile Pro Leu Pro 
        435                 440                 445             


Leu Met Ser Tyr Gly Pro Trp Gln Cys Arg Arg Gly Gly Val Pro Xaa 
    450                 455                 460                 


Ser His Pro Pro Gly Ala Ala Leu Pro Gln Xaa Leu Met Gly 
465                 470                 475             


<210> 2254
<211> 573
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<400> 2254
Met Leu Gly Ser Leu Gly Leu Trp Ala Leu Leu Pro Xaa Ala Val Glu 
1               5                   10                  15      


Ala Pro Pro Asn Arg Arg Xaa Cys Val Phe Phe Glu Ala Pro Gly Val 
            20                  25                  30          


Arg Gly Ser Xaa Lys Xaa Leu Gly Glu Leu Leu Asp Xaa Gly Xaa Glu 
        35                  40                  45              


Leu Pro Arg Ala Ile Arg Cys Leu Tyr Ser Arg Cys Cys Phe Gly Ile 
    50                  55                  60                  


Trp Asn Leu Xaa Gln Asp Arg Ala Gln Val Glu Met Gln Gly Cys Arg 
65                  70                  75                  80  


Asp Ser Asp Glu Pro Gly Cys Glu Ser Leu His Cys Asp Pro Ser Pro 
                85                  90                  95      


Arg Ala His Pro Ser Pro Gly Ser Xaa Leu Phe Xaa Cys Ser Cys Gly 
            100                 105                 110         


Xaa Asp Phe Cys Asn Ala Asn Tyr Ser His Leu Pro Pro Pro Gly Ser 
        115                 120                 125             


Pro Gly Xaa Pro Gly Ser Gln Gly Pro Gln Ala Ala Pro Gly Glu Ser 
    130                 135                 140                 


Ile Trp Met Ala Leu Val Leu Leu Gly Leu Phe Leu Leu Leu Leu Leu 
145                 150                 155                 160 


Leu Leu Gly Ser Ile Ile Leu Ala Leu Leu Gln Arg Lys Asn Tyr Arg 
                165                 170                 175     


Val Arg Gly Glu Pro Val Pro Glu Pro Arg Pro Asp Ser Gly Arg Asp 
            180                 185                 190         


Trp Ser Val Glu Leu Gln Glu Leu Pro Glu Leu Cys Phe Ser Gln Val 
        195                 200                 205             


Ile Arg Glu Gly Gly His Ala Val Val Trp Ala Gly Gln Leu Gln Gly 
    210                 215                 220                 


Lys Leu Val Ala Ile Lys Ala Phe Pro Pro Arg Ser Val Ala Gln Phe 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Leu Tyr Glu Leu Pro Gly Leu Gln His Asp His 
                245                 250                 255     


Ile Val Arg Phe Ile Xaa Ala Ser Arg Gly Gly Pro Gly Arg Leu Leu 
            260                 265                 270         


Ser Gly Pro Leu Leu Val Leu Glu Leu His Pro Lys Gly Ser Leu Cys 
        275                 280                 285             


His Tyr Leu Xaa Gln Tyr Xaa Ser Asp Trp Gly Ser Ser Leu Arg Met 
    290                 295                 300                 


Ala Leu Ser Leu Ala Gln Gly Leu Ala Phe Leu His Glu Glu Arg Trp 
305                 310                 315                 320 


Gln Asn Gly Gln Tyr Lys Pro Gly Ile Ala His Arg Asp Leu Ser Ser 
                325                 330                 335     


Gln Asn Val Leu Ile Arg Glu Asp Gly Ser Cys Ala Ile Gly Asp Leu 
            340                 345                 350         


Gly Leu Ala Leu Val Leu Pro Gly Leu Xaa Gln Pro Pro Ala Trp Xaa 
        355                 360                 365             


Pro Xaa Gln Pro Gln Gly Pro Ala Ala Ile Met Glu Ala Gly Xaa Gln 
    370                 375                 380                 


Arg Tyr Met Ala Pro Glu Leu Leu Asp Lys Xaa Leu Asp Leu Gln Asp 
385                 390                 395                 400 


Trp Gly Met Ala Leu Arg Arg Ala Asp Ile Tyr Ser Leu Ala Leu Leu 
                405                 410                 415     


Leu Trp Glu Ile Leu Ser Arg Cys Pro Asp Leu Arg Pro Asp Ser Ser 
            420                 425                 430         


Pro Pro Pro Phe Gln Leu Ala Tyr Glu Ala Glu Leu Gly Asn Xaa Pro 
        435                 440                 445             


Xaa Ser Asp Glu Leu Trp Ala Leu Ala Val Gln Glu Arg Arg Arg Pro 
    450                 455                 460                 


Tyr Ile Pro Ser Xaa Trp Arg Cys Phe Ala Xaa Asp Pro Asp Gly Leu 
465                 470                 475                 480 


Arg Glu Leu Leu Glu Asp Cys Trp Asp Ala Asp Pro Glu Ala Arg Leu 
                485                 490                 495     


Xaa Ala Glu Cys Val Gln Gln Arg Leu Ala Ala Leu Ala His Pro Gln 
            500                 505                 510         


Glu Ser His Pro Phe Pro Glu Ser Cys Pro Arg Gly Cys Pro Pro Leu 
        515                 520                 525             


Cys Pro Glu Asp Cys Xaa Ser Ile Pro Ala Pro Xaa Ile Leu Pro Cys 
    530                 535                 540                 


Arg Pro Gln Arg Ser Ala Cys His Phe Ser Val Gln Gln Gly Pro Cys 
545                 550                 555                 560 


Ser Arg Asn Pro Gln Pro Ala Cys Xaa Leu Ser Pro Val 
                565                 570             


<210> 2255
<211> 597
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<400> 2255
Met Glu His Arg Gly Pro Pro Pro Glu Tyr Pro Phe Lys Gly Met Pro 
1               5                   10                  15      


Pro Gln Ser Val Val Cys Lys Pro Gln Glu Pro Gly His Phe Tyr Ser 
            20                  25                  30          


Glu His Arg Leu Asn Gln Pro Gly Arg Xaa Glu Gly Gln Leu Met Arg 
        35                  40                  45              


Tyr Gln His Pro Pro Glu Tyr Gly Ala Ala Arg Pro Ala Gln Asp Ile 
    50                  55                  60                  


Ser Leu Pro Leu Ser Ala Arg Asn Ser Gln Pro His Ser Pro Xaa Ser 
65                  70                  75                  80  


Ser Leu Xaa Ser Gly Gly Ser Leu Pro Leu Leu Gln Ser Pro Pro Ser 
                85                  90                  95      


Xaa Arg Leu Ser Pro Ala Arg His Pro Leu Val Pro Asn Gln Gly Asp 
            100                 105                 110         


His Ser Ala His Leu Pro Arg Pro Gln Gln His Phe Leu Pro Asn Gln 
        115                 120                 125             


Ala His Gln Gly Asp His Tyr Arg Leu Ser Gln Pro Gly Leu Ser Gln 
    130                 135                 140                 


Gln Gln Gln Gln Gln Gln Gln Gln His His His His His His His Gln 
145                 150                 155                 160 


Gln Gln Gln Gln Gln Gln Pro Gln Gln Gln Pro Gly Glu Ala Tyr Ser 
                165                 170                 175     


Ala Met Pro Arg Ala Gln Pro Ser Ser Ala Ser Tyr Gln Pro Val Pro 
            180                 185                 190         


Ala Asp Pro Phe Ala Ile Val Ser Arg Ala Gln Gln Met Val Glu Ile 
        195                 200                 205             


Leu Ser Asp Glu Asn Arg Asn Leu Arg Gln Glu Leu Glu Gly Cys Tyr 
    210                 215                 220                 


Glu Lys Val Ala Arg Leu Gln Lys Val Glu Xaa Glu Ile Gln Arg Val 
225                 230                 235                 240 


Ser Glu Ala Tyr Glu Asn Leu Val Lys Ser Ser Ser Lys Arg Glu Ala 
                245                 250                 255     


Leu Glu Lys Ala Met Arg Asn Lys Leu Glu Gly Glu Ile Arg Arg Met 
            260                 265                 270         


His Asp Phe Asn Arg Asp Leu Arg Glu Arg Leu Glu Xaa Ala Asn Lys 
        275                 280                 285             


Gln Leu Ala Glu Lys Glu Tyr Glu Gly Ser Glu Asp Xaa Arg Lys Xaa 
    290                 295                 300                 


Ile Ser Gln Leu Phe Ala Lys Asn Lys Glu Ser Gln Arg Glu Lys Glu 
305                 310                 315                 320 


Lys Leu Glu Ala Glu Leu Ala Xaa Ala Arg Ser Xaa Asn Glu Asp Gln 
                325                 330                 335     


Arg Arg His Ile Glu Ile Arg Asp Gln Ala Leu Ser Asn Ala Gln Ala 
            340                 345                 350         


Lys Val Val Lys Leu Glu Glu Glu Leu Lys Lys Lys Gln Val Tyr Val 
        355                 360                 365             


Asp Lys Val Glu Lys Met Gln Gln Ala Leu Val Gln Leu Gln Ala Ala 
    370                 375                 380                 


Cys Glu Lys Arg Glu Gln Leu Glu His Arg Leu Arg Xaa Arg Leu Glu 
385                 390                 395                 400 


Arg Glu Leu Glu Ser Leu Arg Ile Gln Gln Arg Gln Gly Asn Cys Gln 
                405                 410                 415     


Pro Xaa Asn Val Ser Glu Tyr Asn Ala Ala Ala Leu Met Glu Leu Leu 
            420                 425                 430         


Arg Glu Lys Glu Glu Arg Ile Leu Ala Leu Glu Ala Asp Met Xaa Lys 
        435                 440                 445             


Trp Glu Gln Lys Tyr Leu Glu Glu Asn Val Met Arg His Phe Ala Leu 
    450                 455                 460                 


Asp Ala Ala Ala Xaa Val Ala Ala Gln Arg Asp Xaa Xaa Val Ile Ser 
465                 470                 475                 480 


His Ser Pro Asn Xaa Ser Tyr Asp Xaa Ala Leu Glu Ala Arg Ile Gln 
                485                 490                 495     


Lys Glu Glu Glu Glu Ile Leu Met Ala Asn Lys Arg Cys Leu Asp Met 
            500                 505                 510         


Glu Gly Arg Ile Lys Xaa Leu His Ala Gln Ile Ile Glu Lys Asp Ala 
        515                 520                 525             


Met Ile Lys Val Leu Gln Gln Arg Ser Arg Lys Glu Pro Ser Lys Xaa 
    530                 535                 540                 


Glu Gln Leu Ser Cys Met Arg Pro Ala Lys Ser Leu Met Ser Ile Ser 
545                 550                 555                 560 


Asn Ala Gly Ser Gly Leu Leu Ser His Ser Ser Xaa Leu Xaa Gly Ser 
                565                 570                 575     


Pro Ile Met Glu Glu Lys Arg Asp Asp Lys Ser Trp Lys Gly Ser Leu 
            580                 585                 590         


Gly Asn Asp Ser Lys 
        595         


<210> 2256
<211> 852
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<400> 2256
Met Glu His Arg Gly Pro Pro Pro Glu Tyr Pro Phe Lys Gly Met Pro 
1               5                   10                  15      


Pro Gln Ser Val Val Cys Lys Pro Gln Glu Pro Gly His Phe Tyr Ser 
            20                  25                  30          


Glu His Arg Leu Asn Gln Pro Gly Arg Xaa Glu Gly Gln Leu Met Arg 
        35                  40                  45              


Tyr Gln His Pro Pro Glu Tyr Gly Ala Ala Arg Pro Ala Gln Asp Ile 
    50                  55                  60                  


Ser Leu Pro Leu Ser Ala Arg Asn Ser Gln Pro His Ser Pro Xaa Ser 
65                  70                  75                  80  


Ser Leu Xaa Ser Gly Gly Ser Leu Pro Leu Leu Gln Ser Pro Pro Ser 
                85                  90                  95      


Xaa Arg Leu Ser Pro Ala Arg His Pro Leu Val Pro Asn Gln Gly Asp 
            100                 105                 110         


His Ser Ala His Leu Pro Arg Pro Gln Gln His Phe Leu Pro Asn Gln 
        115                 120                 125             


Ala His Gln Gly Asp His Tyr Arg Leu Ser Gln Pro Gly Leu Ser Gln 
    130                 135                 140                 


Gln Gln Gln Gln Gln Gln Gln Gln His His His His His His His Gln 
145                 150                 155                 160 


Gln Gln Gln Gln Gln Gln Pro Gln Gln Gln Pro Gly Glu Ala Tyr Ser 
                165                 170                 175     


Ala Met Pro Arg Ala Gln Pro Ser Ser Ala Ser Tyr Gln Pro Val Pro 
            180                 185                 190         


Ala Asp Pro Phe Ala Ile Val Ser Arg Ala Gln Gln Met Val Glu Ile 
        195                 200                 205             


Leu Ser Asp Glu Asn Arg Asn Leu Arg Gln Glu Leu Glu Gly Cys Tyr 
    210                 215                 220                 


Glu Lys Val Ala Arg Leu Gln Lys Val Glu Xaa Glu Ile Gln Arg Val 
225                 230                 235                 240 


Ser Glu Ala Tyr Glu Asn Leu Val Lys Ser Ser Ser Lys Arg Glu Ala 
                245                 250                 255     


Leu Glu Lys Ala Met Arg Asn Lys Leu Glu Gly Glu Ile Arg Arg Met 
            260                 265                 270         


His Asp Phe Asn Arg Asp Leu Arg Glu Arg Leu Glu Xaa Ala Asn Lys 
        275                 280                 285             


Gln Leu Ala Glu Lys Glu Tyr Glu Gly Ser Glu Asp Xaa Arg Lys Xaa 
    290                 295                 300                 


Ile Ser Gln Leu Phe Ala Lys Asn Lys Glu Ser Gln Arg Glu Lys Glu 
305                 310                 315                 320 


Lys Leu Glu Ala Glu Leu Ala Xaa Ala Arg Ser Xaa Asn Glu Asp Gln 
                325                 330                 335     


Arg Arg His Ile Glu Ile Arg Asp Gln Ala Leu Ser Asn Ala Gln Ala 
            340                 345                 350         


Lys Val Val Lys Leu Glu Glu Glu Leu Lys Lys Lys Gln Val Tyr Val 
        355                 360                 365             


Asp Lys Val Glu Lys Met Gln Gln Ala Leu Val Gln Leu Gln Ala Ala 
    370                 375                 380                 


Cys Glu Lys Arg Glu Gln Leu Glu His Arg Leu Arg Xaa Arg Leu Glu 
385                 390                 395                 400 


Arg Glu Leu Glu Ser Leu Arg Ile Gln Gln Arg Gln Gly Asn Cys Gln 
                405                 410                 415     


Pro Xaa Asn Val Ser Glu Tyr Asn Ala Ala Ala Leu Met Glu Leu Leu 
            420                 425                 430         


Arg Glu Lys Glu Glu Arg Ile Leu Ala Leu Glu Ala Asp Met Xaa Lys 
        435                 440                 445             


Trp Glu Gln Lys Tyr Leu Glu Glu Asn Val Met Arg His Phe Ala Leu 
    450                 455                 460                 


Asp Ala Ala Ala Xaa Val Ala Ala Gln Arg Asp Xaa Xaa Val Ile Ser 
465                 470                 475                 480 


His Ser Pro Asn Xaa Ser Tyr Asp Xaa Ala Leu Glu Ala Arg Ile Gln 
                485                 490                 495     


Lys Glu Glu Glu Glu Ile Leu Met Ala Asn Lys Arg Cys Leu Asp Met 
            500                 505                 510         


Glu Gly Arg Ile Lys Xaa Leu His Ala Gln Ile Ile Glu Lys Asp Ala 
        515                 520                 525             


Met Ile Lys Val Leu Gln Gln Arg Ser Arg Lys Glu Pro Ser Lys Xaa 
    530                 535                 540                 


Glu Gln Leu Ser Cys Met Arg Pro Ala Lys Ser Leu Met Ser Ile Ser 
545                 550                 555                 560 


Asn Ala Gly Ser Gly Leu Leu Ser His Ser Ser Xaa Leu Xaa Gly Ser 
                565                 570                 575     


Pro Ile Met Glu Glu Lys Arg Asp Asp Lys Ser Trp Lys Gly Ser Leu 
            580                 585                 590         


Gly Ile Leu Leu Gly Gly Asp Tyr Arg Ala Glu Tyr Val Pro Ser Xaa 
        595                 600                 605             


Pro Ser Pro Val Pro Pro Ser Xaa Pro Leu Leu Ser Ala His Ser Lys 
    610                 615                 620                 


Xaa Gly Ser Arg Asp Cys Ser Xaa Gln Xaa Glu Arg Gly Xaa Glu Ser 
625                 630                 635                 640 


Asn Lys Xaa Ala Ala Val Ala Pro Ile Ser Val Pro Ala Pro Val Ala 
                645                 650                 655     


Ala Ala Ala Xaa Ala Ala Ala Ile Xaa Ala Xaa Ala Ala Xaa Ile Xaa 
            660                 665                 670         


Xaa Xaa Met Val Ala Ala Ala Pro Val Ala Val Ala Ala Ala Ala Ala 
        675                 680                 685             


Pro Ala Ala Ala Ala Ala Pro Ser Pro Ala Xaa Ala Ala Ala Xaa Ala 
    690                 695                 700                 


Ala Ala Val Ser Pro Ala Ala Ala Gly Gln Ile Pro Ala Ala Ala Ser 
705                 710                 715                 720 


Val Ala Ser Ala Ala Ala Val Ala Pro Ser Ala Ala Ala Ala Ala Ala 
                725                 730                 735     


Val Gln Val Ala Pro Ala Ala Pro Ala Pro Val Pro Ala Pro Ala Leu 
            740                 745                 750         


Val Pro Val Pro Ala Pro Ala Ala Ala Gln Ala Ser Ala Pro Ala Gln 
        755                 760                 765             


Xaa Gln Ala Pro Xaa Ser Ala Pro Ala Val Ala Pro Xaa Pro Ala Pro 
    770                 775                 780                 


Xaa Pro Xaa Pro Ala Val Ala Gln Ala Glu Val Pro Ala Ser Pro Ala 
785                 790                 795                 800 


Xaa Gly Pro Gly Pro His Arg Leu Ser Ile Pro Ser Leu Xaa Cys Asn 
                805                 810                 815     


Pro Asp Lys Xaa Asp Gly Pro Val Phe His Ser Asn Xaa Leu Glu Arg 
            820                 825                 830         


Lys Xaa Pro Ile Gln Ile Leu Gly Gln Glu Pro Asp Ala Glu Met Val 
        835                 840                 845             


Glu Tyr Leu Ile 
    850         


<210> 2257
<211> 675
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<400> 2257
Met Pro Arg Ala Gln Pro Ser Ser Ala Ser Tyr Gln Pro Val Pro Ala 
1               5                   10                  15      


Asp Pro Phe Ala Ile Val Ser Arg Ala Gln Gln Met Val Glu Ile Leu 
            20                  25                  30          


Ser Asp Glu Asn Arg Asn Leu Arg Gln Glu Leu Glu Gly Cys Tyr Glu 
        35                  40                  45              


Lys Val Ala Arg Leu Gln Lys Val Glu Xaa Glu Ile Gln Arg Val Ser 
    50                  55                  60                  


Glu Ala Tyr Glu Asn Leu Val Lys Ser Ser Ser Lys Arg Glu Ala Leu 
65                  70                  75                  80  


Glu Lys Ala Met Arg Asn Lys Leu Glu Gly Glu Ile Arg Arg Met His 
                85                  90                  95      


Asp Phe Asn Arg Asp Leu Arg Glu Arg Leu Glu Xaa Ala Asn Lys Gln 
            100                 105                 110         


Leu Ala Glu Lys Glu Tyr Glu Gly Ser Glu Asp Xaa Arg Lys Xaa Ile 
        115                 120                 125             


Ser Gln Leu Phe Ala Lys Asn Lys Glu Ser Gln Arg Glu Lys Glu Lys 
    130                 135                 140                 


Leu Glu Ala Glu Leu Ala Xaa Ala Arg Ser Xaa Asn Glu Asp Gln Arg 
145                 150                 155                 160 


Arg His Ile Glu Ile Arg Asp Gln Ala Leu Ser Asn Ala Gln Ala Lys 
                165                 170                 175     


Val Val Lys Leu Glu Glu Glu Leu Lys Lys Lys Gln Val Tyr Val Asp 
            180                 185                 190         


Lys Val Glu Lys Met Gln Gln Ala Leu Val Gln Leu Gln Ala Ala Cys 
        195                 200                 205             


Glu Lys Arg Glu Gln Leu Glu His Arg Leu Arg Xaa Arg Leu Glu Arg 
    210                 215                 220                 


Glu Leu Glu Ser Leu Arg Ile Gln Gln Arg Gln Gly Asn Cys Gln Pro 
225                 230                 235                 240 


Xaa Asn Val Ser Glu Tyr Asn Ala Ala Ala Leu Met Glu Leu Leu Arg 
                245                 250                 255     


Glu Lys Glu Glu Arg Ile Leu Ala Leu Glu Ala Asp Met Xaa Lys Trp 
            260                 265                 270         


Glu Gln Lys Tyr Leu Glu Glu Asn Val Met Arg His Phe Ala Leu Asp 
        275                 280                 285             


Ala Ala Ala Xaa Val Ala Ala Gln Arg Asp Xaa Xaa Val Ile Ser His 
    290                 295                 300                 


Ser Pro Asn Xaa Ser Tyr Asp Xaa Ala Leu Glu Ala Arg Ile Gln Lys 
305                 310                 315                 320 


Glu Glu Glu Glu Ile Leu Met Ala Asn Lys Arg Cys Leu Asp Met Glu 
                325                 330                 335     


Gly Arg Ile Lys Xaa Leu His Ala Gln Ile Ile Glu Lys Asp Ala Met 
            340                 345                 350         


Ile Lys Val Leu Gln Gln Arg Ser Arg Lys Glu Pro Ser Lys Xaa Glu 
        355                 360                 365             


Gln Leu Ser Cys Met Arg Pro Ala Lys Ser Leu Met Ser Ile Ser Asn 
    370                 375                 380                 


Ala Gly Ser Gly Leu Leu Ser His Ser Ser Xaa Leu Xaa Gly Ser Pro 
385                 390                 395                 400 


Ile Met Glu Glu Lys Arg Asp Asp Lys Ser Trp Lys Gly Ser Leu Gly 
                405                 410                 415     


Ile Leu Leu Gly Gly Asp Tyr Arg Ala Glu Tyr Val Pro Ser Xaa Pro 
            420                 425                 430         


Ser Pro Val Pro Pro Ser Xaa Pro Leu Leu Ser Ala His Ser Lys Xaa 
        435                 440                 445             


Gly Ser Arg Asp Cys Ser Xaa Gln Xaa Glu Arg Gly Xaa Glu Ser Asn 
    450                 455                 460                 


Lys Xaa Ala Ala Val Ala Pro Ile Ser Val Pro Ala Pro Val Ala Ala 
465                 470                 475                 480 


Ala Ala Xaa Ala Ala Ala Ile Xaa Ala Xaa Ala Ala Xaa Ile Xaa Xaa 
                485                 490                 495     


Xaa Met Val Ala Ala Ala Pro Val Ala Val Ala Ala Ala Ala Ala Pro 
            500                 505                 510         


Ala Ala Ala Ala Ala Pro Ser Pro Ala Xaa Ala Ala Ala Xaa Ala Ala 
        515                 520                 525             


Ala Val Ser Pro Ala Ala Ala Gly Gln Ile Pro Ala Ala Ala Ser Val 
    530                 535                 540                 


Ala Ser Ala Ala Ala Val Ala Pro Ser Ala Ala Ala Ala Ala Ala Val 
545                 550                 555                 560 


Gln Val Ala Pro Ala Ala Pro Ala Pro Val Pro Ala Pro Ala Leu Val 
                565                 570                 575     


Pro Val Pro Ala Pro Ala Ala Ala Gln Ala Ser Ala Pro Ala Gln Xaa 
            580                 585                 590         


Gln Ala Pro Xaa Ser Ala Pro Ala Val Ala Pro Xaa Pro Ala Pro Xaa 
        595                 600                 605             


Pro Xaa Pro Ala Val Ala Gln Ala Glu Val Pro Ala Ser Pro Ala Xaa 
    610                 615                 620                 


Gly Pro Gly Pro His Arg Leu Ser Ile Pro Ser Leu Xaa Cys Asn Pro 
625                 630                 635                 640 


Asp Lys Xaa Asp Gly Pro Val Phe His Ser Asn Xaa Leu Glu Arg Lys 
                645                 650                 655     


Xaa Pro Ile Gln Ile Leu Gly Gln Glu Pro Asp Ala Glu Met Val Glu 
            660                 665                 670         


Tyr Leu Ile 
        675 


<210> 2258
<211> 1084
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1017)..(1017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1066)..(1066)
<223> Selenocysteine

<400> 2258
Met Arg Asn Ser Glu Glu Gln Pro Ser Gly Gly Xaa Xaa Val Leu Gln 
1               5                   10                  15      


Arg Leu Leu Gln Glu Gln Leu Arg Tyr Gly Asn Pro Ser Glu Asn Arg 
            20                  25                  30          


Ser Leu Leu Ala Ile His Gln Gln Ala Xaa Gly Asn Gly Pro Pro Phe 
        35                  40                  45              


Pro Ser Gly Ser Gly Asn Pro Gly Pro Gln Ser Asp Val Leu Ser Pro 
    50                  55                  60                  


Gln Asp His His Gln Gln Leu Val Ala His Ala Ala Arg Gln Glu Pro 
65                  70                  75                  80  


Gln Gly Gln Glu Ile Gln Ser Glu Asn Leu Ile Met Glu Lys Gln Leu 
                85                  90                  95      


Ser Pro Arg Met Gln Asn Asn Glu Glu Leu Pro Xaa Tyr Glu Glu Ala 
            100                 105                 110         


Lys Val Gln Ser Gln Tyr Phe Arg Gly Gln Gln His Ala Ser Val Gly 
        115                 120                 125             


Ala Ala Phe Tyr Val Xaa Gly Val Xaa Asn Gln Lys Met Arg Xaa Glu 
    130                 135                 140                 


Gly Arg Pro Ser Val Gln Arg Leu Asn Pro Gly Lys Met His Gln Asp 
145                 150                 155                 160 


Glu Gly Leu Arg Asp Leu Lys Gln Gly His Val Arg Ser Leu Ser Glu 
                165                 170                 175     


Arg Leu Met Gln Met Ser Leu Ala Xaa Ser Gly Val Lys Ala His Pro 
            180                 185                 190         


Pro Val Xaa Ser Ala Pro Leu Ser Pro Pro Gln Pro Asn Asp Leu Tyr 
        195                 200                 205             


Lys Asn Pro Xaa Ser Ser Ser Glu Phe Tyr Lys Ala Gln Gly Pro Leu 
    210                 215                 220                 


Pro Asn Gln His Ser Leu Lys Gly Met Glu His Arg Gly Pro Pro Pro 
225                 230                 235                 240 


Glu Tyr Pro Phe Lys Gly Met Pro Pro Gln Ser Val Val Cys Lys Pro 
                245                 250                 255     


Gln Glu Pro Gly His Phe Tyr Ser Glu His Arg Leu Asn Gln Pro Gly 
            260                 265                 270         


Arg Xaa Glu Gly Gln Leu Met Arg Tyr Gln His Pro Pro Glu Tyr Gly 
        275                 280                 285             


Ala Ala Arg Pro Ala Gln Asp Ile Ser Leu Pro Leu Ser Ala Arg Asn 
    290                 295                 300                 


Ser Gln Pro His Ser Pro Xaa Ser Ser Leu Xaa Ser Gly Gly Ser Leu 
305                 310                 315                 320 


Pro Leu Leu Gln Ser Pro Pro Ser Xaa Arg Leu Ser Pro Ala Arg His 
                325                 330                 335     


Pro Leu Val Pro Asn Gln Gly Asp His Ser Ala His Leu Pro Arg Pro 
            340                 345                 350         


Gln Gln His Phe Leu Pro Asn Gln Ala His Gln Gly Asp His Tyr Arg 
        355                 360                 365             


Leu Ser Gln Pro Gly Leu Ser Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    370                 375                 380                 


His His His His His His His Gln Gln Gln Gln Gln Gln Gln Pro Gln 
385                 390                 395                 400 


Gln Gln Pro Gly Glu Ala Tyr Ser Ala Met Pro Arg Ala Gln Pro Ser 
                405                 410                 415     


Ser Ala Ser Tyr Gln Pro Val Pro Ala Asp Pro Phe Ala Ile Val Ser 
            420                 425                 430         


Arg Ala Gln Gln Met Val Glu Ile Leu Ser Asp Glu Asn Arg Asn Leu 
        435                 440                 445             


Arg Gln Glu Leu Glu Gly Cys Tyr Glu Lys Val Ala Arg Leu Gln Lys 
    450                 455                 460                 


Val Glu Xaa Glu Ile Gln Arg Val Ser Glu Ala Tyr Glu Asn Leu Val 
465                 470                 475                 480 


Lys Ser Ser Ser Lys Arg Glu Ala Leu Glu Lys Ala Met Arg Asn Lys 
                485                 490                 495     


Leu Glu Gly Glu Ile Arg Arg Met His Asp Phe Asn Arg Asp Leu Arg 
            500                 505                 510         


Glu Arg Leu Glu Xaa Ala Asn Lys Gln Leu Ala Glu Lys Glu Tyr Glu 
        515                 520                 525             


Gly Ser Glu Asp Xaa Arg Lys Xaa Ile Ser Gln Leu Phe Ala Lys Asn 
    530                 535                 540                 


Lys Glu Ser Gln Arg Glu Lys Glu Lys Leu Glu Ala Glu Leu Ala Xaa 
545                 550                 555                 560 


Ala Arg Ser Xaa Asn Glu Asp Gln Arg Arg His Ile Glu Ile Arg Asp 
                565                 570                 575     


Gln Ala Leu Ser Asn Ala Gln Ala Lys Val Val Lys Leu Glu Glu Glu 
            580                 585                 590         


Leu Lys Lys Lys Gln Val Tyr Val Asp Lys Val Glu Lys Met Gln Gln 
        595                 600                 605             


Ala Leu Val Gln Leu Gln Ala Ala Cys Glu Lys Arg Glu Gln Leu Glu 
    610                 615                 620                 


His Arg Leu Arg Xaa Arg Leu Glu Arg Glu Leu Glu Ser Leu Arg Ile 
625                 630                 635                 640 


Gln Gln Arg Gln Gly Asn Cys Gln Pro Xaa Asn Val Ser Glu Tyr Asn 
                645                 650                 655     


Ala Ala Ala Leu Met Glu Leu Leu Arg Glu Lys Glu Glu Arg Ile Leu 
            660                 665                 670         


Ala Leu Glu Ala Asp Met Xaa Lys Trp Glu Gln Lys Tyr Leu Glu Glu 
        675                 680                 685             


Asn Val Met Arg His Phe Ala Leu Asp Ala Ala Ala Xaa Val Ala Ala 
    690                 695                 700                 


Gln Arg Asp Xaa Xaa Val Ile Ser His Ser Pro Asn Xaa Ser Tyr Asp 
705                 710                 715                 720 


Xaa Ala Leu Glu Ala Arg Ile Gln Lys Glu Glu Glu Glu Ile Leu Met 
                725                 730                 735     


Ala Asn Lys Arg Cys Leu Asp Met Glu Gly Arg Ile Lys Xaa Leu His 
            740                 745                 750         


Ala Gln Ile Ile Glu Lys Asp Ala Met Ile Lys Val Leu Gln Gln Arg 
        755                 760                 765             


Ser Arg Lys Glu Pro Ser Lys Xaa Glu Gln Leu Ser Cys Met Arg Pro 
    770                 775                 780                 


Ala Lys Ser Leu Met Ser Ile Ser Asn Ala Gly Ser Gly Leu Leu Ser 
785                 790                 795                 800 


His Ser Ser Xaa Leu Xaa Gly Ser Pro Ile Met Glu Glu Lys Arg Asp 
                805                 810                 815     


Asp Lys Ser Trp Lys Gly Ser Leu Gly Ile Leu Leu Gly Gly Asp Tyr 
            820                 825                 830         


Arg Ala Glu Tyr Val Pro Ser Xaa Pro Ser Pro Val Pro Pro Ser Xaa 
        835                 840                 845             


Pro Leu Leu Ser Ala His Ser Lys Xaa Gly Ser Arg Asp Cys Ser Xaa 
    850                 855                 860                 


Gln Xaa Glu Arg Gly Xaa Glu Ser Asn Lys Xaa Ala Ala Val Ala Pro 
865                 870                 875                 880 


Ile Ser Val Pro Ala Pro Val Ala Ala Ala Ala Xaa Ala Ala Ala Ile 
                885                 890                 895     


Xaa Ala Xaa Ala Ala Xaa Ile Xaa Xaa Xaa Met Val Ala Ala Ala Pro 
            900                 905                 910         


Val Ala Val Ala Ala Ala Ala Ala Pro Ala Ala Ala Ala Ala Pro Ser 
        915                 920                 925             


Pro Ala Xaa Ala Ala Ala Xaa Ala Ala Ala Val Ser Pro Ala Ala Ala 
    930                 935                 940                 


Gly Gln Ile Pro Ala Ala Ala Ser Val Ala Ser Ala Ala Ala Val Ala 
945                 950                 955                 960 


Pro Ser Ala Ala Ala Ala Ala Ala Val Gln Val Ala Pro Ala Ala Pro 
                965                 970                 975     


Ala Pro Val Pro Ala Pro Ala Leu Val Pro Val Pro Ala Pro Ala Ala 
            980                 985                 990         


Ala Gln Ala Ser Ala Pro Ala Gln  Xaa Gln Ala Pro Xaa  Ser Ala Pro 
        995                 1000                 1005             


Ala Val  Ala Pro Xaa Pro Ala  Pro Xaa Pro Xaa Pro  Ala Val Ala 
    1010                 1015                 1020             


Gln Ala  Glu Val Pro Ala Ser  Pro Ala Xaa Gly Pro  Gly Pro His 
    1025                 1030                 1035             


Arg Leu  Ser Ile Pro Ser Leu  Xaa Cys Asn Pro Asp  Lys Xaa Asp 
    1040                 1045                 1050             


Gly Pro  Val Phe His Ser Asn  Xaa Leu Glu Arg Lys  Xaa Pro Ile 
    1055                 1060                 1065             


Gln Ile  Leu Gly Gln Glu Pro  Asp Ala Glu Met Val  Glu Tyr Leu 
    1070                 1075                 1080             


Ile 
    


<210> 2259
<211> 145
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<400> 2259
Met Asp Leu Ser Glu Lys Trp Xaa Leu Glu Glu Gly Ala Trp Leu Ser 
1               5                   10                  15      


His Ala Gly Ile His His Phe Ala Ser Xaa Arg Ala Asp Ser Glu Phe 
            20                  25                  30          


Val Glu Ala Ser Pro Ala Ser Tyr Ser Pro Asp Glu Leu Gly Ser Pro 
        35                  40                  45              


Ser Ala Cys Tyr Ser Pro Ser Ser Pro Val Gln Val Leu Glu Asp Ser 
    50                  55                  60                  


Xaa Tyr Phe Ser Pro Asp Phe Gln Leu Tyr Ser Gly Arg His Glu Xaa 
65                  70                  75                  80  


Ser Ala Leu Xaa Val Glu Ala Xaa Ser Ser Ile Arg Glu Lys Val Val 
                85                  90                  95      


Glu Asp Pro Leu Cys Asn Phe His Ser Pro Asn Phe Leu Arg Ile Ser 
            100                 105                 110         


Glu Val Glu Met Arg Gly Ser Glu Asp Ala Ala Ala Gly Xaa Val Leu 
        115                 120                 125             


Gln Arg Leu Ile Gln Glu Gln Leu Arg Tyr Gly Xaa Pro Xaa Glu Asn 
    130                 135                 140                 


Met 
145 


<210> 2260
<211> 956
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<400> 2260
Met Trp Arg Ala Lys Leu Arg Arg Gly Xaa Cys Glu Pro Ala Val Lys 
1               5                   10                  15      


Gly Ser Pro Ser Ala Cys Tyr Ser Pro Ser Ser Pro Val Gln Val Leu 
            20                  25                  30          


Glu Asp Ser Xaa Tyr Phe Ser Pro Asp Phe Gln Leu Tyr Ser Gly Arg 
        35                  40                  45              


His Glu Xaa Ser Ala Leu Xaa Val Glu Ala Xaa Ser Ser Ile Arg Glu 
    50                  55                  60                  


Lys Val Val Glu Asp Pro Leu Cys Asn Phe His Ser Pro Asn Phe Leu 
65                  70                  75                  80  


Arg Ile Ser Glu Val Glu Met Arg Gly Ser Glu Asp Ala Ala Ala Gly 
                85                  90                  95      


Xaa Val Leu Gln Arg Leu Ile Gln Glu Gln Leu Arg Tyr Gly Xaa Pro 
            100                 105                 110         


Xaa Glu Asn Met Asn Leu Leu Ala Ile Gln His Gln Ala Xaa Gly Ser 
        115                 120                 125             


Ala Gly Pro Ala His Pro Xaa Asn Asn Phe Ser Ser Xaa Glu Asn Leu 
    130                 135                 140                 


Xaa Gln Glu Asp Pro Gln Met Val Tyr Gln Ser Ala Arg Gln Glu Pro 
145                 150                 155                 160 


Gln Gly Gln Glu His Gln Val Asp Asn Xaa Val Met Glu Lys Gln Val 
                165                 170                 175     


Arg Ser Xaa Gln Pro Gln Gln Asn Asn Glu Glu Leu Pro Xaa Tyr Glu 
            180                 185                 190         


Glu Ala Lys Ala Gln Ser Gln Phe Phe Arg Gly Gln Gln Gln Gln Gln 
        195                 200                 205             


Gln Gln Gln Gly Ala Val Gly His Gly Tyr Tyr Met Ala Gly Gly Xaa 
    210                 215                 220                 


Ser Gln Lys Ser Arg Xaa Glu Gly Arg Pro Xaa Val Asn Arg Ala Asn 
225                 230                 235                 240 


Ser Gly Gln Ala His Lys Asp Glu Ala Leu Lys Glu Leu Lys Gln Gly 
                245                 250                 255     


His Val Arg Ser Leu Ser Glu Arg Ile Met Gln Leu Ser Leu Glu Arg 
            260                 265                 270         


Asn Gly Ala Lys Gln His Leu Pro Gly Ser Gly Asn Gly Lys Gly Phe 
        275                 280                 285             


Lys Val Gly Gly Gly Pro Ser Pro Ala Gln Pro Ala Gly Lys Val Leu 
    290                 295                 300                 


Asp Pro Arg Gly Pro Pro Pro Glu Tyr Pro Phe Lys Xaa Lys Gln Met 
305                 310                 315                 320 


Met Ser Pro Val Ser Lys Xaa Gln Glu His Gly Leu Phe Tyr Gly Asp 
                325                 330                 335     


Gln His Pro Gly Met Leu His Glu Met Val Lys Pro Tyr Pro Ala Pro 
            340                 345                 350         


Gln Pro Val Arg Xaa Asp Val Ala Val Leu Arg Tyr Gln Pro Pro Pro 
        355                 360                 365             


Glu Tyr Gly Val Xaa Ser Arg Pro Cys Gln Leu Pro Phe Pro Ser Xaa 
    370                 375                 380                 


Met Gln Gln His Ser Pro Met Ser Ser Gln Xaa Ser Ser Ala Ser Gly 
385                 390                 395                 400 


Pro Leu His Ser Val Ser Leu Pro Leu Pro Leu Pro Met Ala Leu Gly 
                405                 410                 415     


Ala Pro Gln Pro Pro Pro Ala Ala Ser Pro Ser Gln Gln Leu Gly Pro 
            420                 425                 430         


Asp Ala Phe Ala Ile Val Glu Arg Ala Gln Gln Met Val Glu Ile Leu 
        435                 440                 445             


Xaa Glu Glu Asn Arg Val Leu His Gln Glu Leu Gln Gly Tyr Tyr Asp 
    450                 455                 460                 


Asn Ala Asp Lys Leu His Lys Phe Glu Lys Glu Leu Gln Arg Ile Ser 
465                 470                 475                 480 


Glu Ala Tyr Glu Ser Leu Val Lys Ser Xaa Xaa Lys Arg Glu Ser Leu 
                485                 490                 495     


Asp Lys Ala Met Arg Asn Lys Leu Glu Gly Glu Ile Arg Arg Leu His 
            500                 505                 510         


Asp Phe Asn Arg Asp Leu Arg Asp Arg Leu Glu Xaa Ala Asn Arg Gln 
        515                 520                 525             


Leu Ser Ser Arg Glu Tyr Glu Gly His Glu Asp Lys Ala Ala Glu Gly 
    530                 535                 540                 


His Tyr Ala Ser Gln Asn Lys Glu Phe Leu Lys Glu Lys Glu Lys Leu 
545                 550                 555                 560 


Glu Met Glu Leu Ala Ala Val Arg Xaa Ala Ser Glu Asp His Arg Arg 
                565                 570                 575     


His Ile Glu Ile Leu Asp Gln Ala Leu Ser Asn Ala Gln Ala Arg Val 
            580                 585                 590         


Ile Lys Leu Glu Glu Glu Leu Arg Glu Lys Gln Ala Tyr Val Glu Lys 
        595                 600                 605             


Val Glu Lys Leu Gln Gln Ala Leu Xaa Gln Leu Gln Ser Ala Cys Glu 
    610                 615                 620                 


Lys Arg Glu Gln Met Glu Arg Arg Leu Arg Xaa Trp Leu Glu Arg Glu 
625                 630                 635                 640 


Leu Asp Ala Leu Arg Xaa Gln Gln Lys His Gly Asn Gly Gln Pro Ala 
                645                 650                 655     


Asn Met Pro Glu Tyr Asn Ala Pro Ala Leu Leu Glu Leu Val Arg Glu 
            660                 665                 670         


Lys Glu Glu Arg Ile Leu Ala Leu Glu Ala Asp Met Xaa Lys Trp Glu 
        675                 680                 685             


Gln Lys Tyr Leu Glu Glu Ser Xaa Ile Arg His Phe Ala Met Asn Ala 
    690                 695                 700                 


Ala Ala Xaa Ala Ala Ala Glu Arg Asp Xaa Xaa Ile Ile Asn His Ser 
705                 710                 715                 720 


Arg Asn Gly Ser Tyr Gly Glu Ser Ser Leu Glu Ala His Ile Trp Gln 
                725                 730                 735     


Glu Glu Glu Glu Val Val Gln Ala Asn Arg Arg Cys Gln Asp Met Glu 
            740                 745                 750         


Tyr Xaa Ile Lys Asn Leu His Ala Lys Ile Ile Glu Lys Asp Ala Met 
        755                 760                 765             


Ile Lys Val Leu Gln Gln Arg Ser Arg Lys Asp Ala Gly Lys Xaa Asp 
    770                 775                 780                 


Ser Ser Ser Leu Arg Pro Ala Arg Ser Val Pro Ser Ile Ala Ala Ala 
785                 790                 795                 800 


Xaa Gly Xaa His Ser Arg Gln Xaa Ser Leu Xaa Ser Ser Gln Leu Ala 
                805                 810                 815     


Glu Glu Lys Lys Glu Glu Lys Xaa Trp Lys Gly Ser Ile Gly Leu Leu 
            820                 825                 830         


Leu Gly Lys Glu His His Glu His Ala Ser Ala Pro Leu Leu Pro Pro 
        835                 840                 845             


Pro Pro Xaa Ser Ala Leu Ser Ser Ile Ala Ser Xaa Xaa Ala Ala Ser 
    850                 855                 860                 


Ser Ala His Ala Lys Xaa Gly Ser Lys Asp Ser Ser Xaa Gln Xaa Asp 
865                 870                 875                 880 


Lys Ser Ala Glu Leu Phe Trp Pro Ser Met Ala Ser Leu Pro Ser Arg 
                885                 890                 895     


Gly Arg Leu Ser Xaa Xaa Pro Ala His Ser Pro Val Leu Lys His Pro 
            900                 905                 910         


Ala Ala Lys Gly Xaa Ala Glu Lys Leu Glu Asn Ser Pro Gly His Gly 
        915                 920                 925             


Lys Ser Pro Asp His Arg Gly Arg Val Ser Ser Leu Leu His Lys Pro 
    930                 935                 940                 


Glu Phe Pro Asp Gly Glu Met Met Glu Val Leu Ile 
945                 950                 955     


<210> 2261
<211> 906
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<400> 2261
Met Trp Arg Ala Lys Leu Arg Arg Gly Xaa Cys Glu Pro Ala Val Lys 
1               5                   10                  15      


Val Glu Asp Pro Leu Cys Asn Phe His Ser Pro Asn Phe Leu Arg Ile 
            20                  25                  30          


Ser Glu Val Glu Met Arg Gly Ser Glu Asp Ala Ala Ala Gly Xaa Val 
        35                  40                  45              


Leu Gln Arg Leu Ile Gln Glu Gln Leu Arg Tyr Gly Xaa Pro Xaa Glu 
    50                  55                  60                  


Asn Met Asn Leu Leu Ala Ile Gln His Gln Ala Xaa Gly Ser Ala Gly 
65                  70                  75                  80  


Pro Ala His Pro Xaa Asn Asn Phe Ser Ser Xaa Glu Asn Leu Xaa Gln 
                85                  90                  95      


Glu Asp Pro Gln Met Val Tyr Gln Ser Ala Arg Gln Glu Pro Gln Gly 
            100                 105                 110         


Gln Glu His Gln Val Asp Asn Xaa Val Met Glu Lys Gln Val Arg Ser 
        115                 120                 125             


Xaa Gln Pro Gln Gln Asn Asn Glu Glu Leu Pro Xaa Tyr Glu Glu Ala 
    130                 135                 140                 


Lys Ala Gln Ser Gln Phe Phe Arg Gly Gln Gln Gln Gln Gln Gln Gln 
145                 150                 155                 160 


Gln Gly Ala Val Gly His Gly Tyr Tyr Met Ala Gly Gly Xaa Ser Gln 
                165                 170                 175     


Lys Ser Arg Xaa Glu Gly Arg Pro Xaa Val Asn Arg Ala Asn Ser Gly 
            180                 185                 190         


Gln Ala His Lys Asp Glu Ala Leu Lys Glu Leu Lys Gln Gly His Val 
        195                 200                 205             


Arg Ser Leu Ser Glu Arg Ile Met Gln Leu Ser Leu Glu Arg Asn Gly 
    210                 215                 220                 


Ala Lys Gln His Leu Pro Gly Ser Gly Asn Gly Lys Gly Phe Lys Val 
225                 230                 235                 240 


Gly Gly Gly Pro Ser Pro Ala Gln Pro Ala Gly Lys Val Leu Asp Pro 
                245                 250                 255     


Arg Gly Pro Pro Pro Glu Tyr Pro Phe Lys Xaa Lys Gln Met Met Ser 
            260                 265                 270         


Pro Val Ser Lys Xaa Gln Glu His Gly Leu Phe Tyr Gly Asp Gln His 
        275                 280                 285             


Pro Gly Met Leu His Glu Met Val Lys Pro Tyr Pro Ala Pro Gln Pro 
    290                 295                 300                 


Val Arg Xaa Asp Val Ala Val Leu Arg Tyr Gln Pro Pro Pro Glu Tyr 
305                 310                 315                 320 


Gly Val Xaa Ser Arg Pro Cys Gln Leu Pro Phe Pro Ser Xaa Met Gln 
                325                 330                 335     


Gln His Ser Pro Met Ser Ser Gln Xaa Ser Ser Ala Ser Gly Pro Leu 
            340                 345                 350         


His Ser Val Ser Leu Pro Leu Pro Leu Pro Met Ala Leu Gly Ala Pro 
        355                 360                 365             


Gln Pro Pro Pro Ala Ala Ser Pro Ser Gln Gln Leu Gly Pro Asp Ala 
    370                 375                 380                 


Phe Ala Ile Val Glu Arg Ala Gln Gln Met Val Glu Ile Leu Xaa Glu 
385                 390                 395                 400 


Glu Asn Arg Val Leu His Gln Glu Leu Gln Gly Tyr Tyr Asp Asn Ala 
                405                 410                 415     


Asp Lys Leu His Lys Phe Glu Lys Glu Leu Gln Arg Ile Ser Glu Ala 
            420                 425                 430         


Tyr Glu Ser Leu Val Lys Ser Xaa Xaa Lys Arg Glu Ser Leu Asp Lys 
        435                 440                 445             


Ala Met Arg Asn Lys Leu Glu Gly Glu Ile Arg Arg Leu His Asp Phe 
    450                 455                 460                 


Asn Arg Asp Leu Arg Asp Arg Leu Glu Xaa Ala Asn Arg Gln Leu Ser 
465                 470                 475                 480 


Ser Arg Glu Tyr Glu Gly His Glu Asp Lys Ala Ala Glu Gly His Tyr 
                485                 490                 495     


Ala Ser Gln Asn Lys Glu Phe Leu Lys Glu Lys Glu Lys Leu Glu Met 
            500                 505                 510         


Glu Leu Ala Ala Val Arg Xaa Ala Ser Glu Asp His Arg Arg His Ile 
        515                 520                 525             


Glu Ile Leu Asp Gln Ala Leu Ser Asn Ala Gln Ala Arg Val Ile Lys 
    530                 535                 540                 


Leu Glu Glu Glu Leu Arg Glu Lys Gln Ala Tyr Val Glu Lys Val Glu 
545                 550                 555                 560 


Lys Leu Gln Gln Ala Leu Xaa Gln Leu Gln Ser Ala Cys Glu Lys Arg 
                565                 570                 575     


Glu Gln Met Glu Arg Arg Leu Arg Xaa Trp Leu Glu Arg Glu Leu Asp 
            580                 585                 590         


Ala Leu Arg Xaa Gln Gln Lys His Gly Asn Gly Gln Pro Ala Asn Met 
        595                 600                 605             


Pro Glu Tyr Asn Ala Pro Ala Leu Leu Glu Leu Val Arg Glu Lys Glu 
    610                 615                 620                 


Glu Arg Ile Leu Ala Leu Glu Ala Asp Met Xaa Lys Trp Glu Gln Lys 
625                 630                 635                 640 


Tyr Leu Glu Glu Ser Xaa Ile Arg His Phe Ala Met Asn Ala Ala Ala 
                645                 650                 655     


Xaa Ala Ala Ala Glu Arg Asp Xaa Xaa Ile Ile Asn His Ser Arg Asn 
            660                 665                 670         


Gly Ser Tyr Gly Glu Ser Ser Leu Glu Ala His Ile Trp Gln Glu Glu 
        675                 680                 685             


Glu Glu Val Val Gln Ala Asn Arg Arg Cys Gln Asp Met Glu Tyr Xaa 
    690                 695                 700                 


Ile Lys Asn Leu His Ala Lys Ile Ile Glu Lys Asp Ala Met Ile Lys 
705                 710                 715                 720 


Val Leu Gln Gln Arg Ser Arg Lys Asp Ala Gly Lys Xaa Asp Ser Ser 
                725                 730                 735     


Ser Leu Arg Pro Ala Arg Ser Val Pro Ser Ile Ala Ala Ala Xaa Gly 
            740                 745                 750         


Xaa His Ser Arg Gln Xaa Ser Leu Xaa Ser Ser Gln Leu Ala Glu Glu 
        755                 760                 765             


Lys Lys Glu Glu Lys Xaa Trp Lys Gly Ser Ile Gly Leu Leu Leu Gly 
    770                 775                 780                 


Lys Glu His His Glu His Ala Ser Ala Pro Leu Leu Pro Pro Pro Pro 
785                 790                 795                 800 


Xaa Ser Ala Leu Ser Ser Ile Ala Ser Xaa Xaa Ala Ala Ser Ser Ala 
                805                 810                 815     


His Ala Lys Xaa Gly Ser Lys Asp Ser Ser Xaa Gln Xaa Asp Lys Ser 
            820                 825                 830         


Ala Glu Leu Phe Trp Pro Ser Met Ala Ser Leu Pro Ser Arg Gly Arg 
        835                 840                 845             


Leu Ser Xaa Xaa Pro Ala His Ser Pro Val Leu Lys His Pro Ala Ala 
    850                 855                 860                 


Lys Gly Xaa Ala Glu Lys Leu Glu Asn Ser Pro Gly His Gly Lys Ser 
865                 870                 875                 880 


Pro Asp His Arg Gly Arg Val Ser Ser Leu Leu His Lys Pro Glu Phe 
                885                 890                 895     


Pro Asp Gly Glu Met Met Glu Val Leu Ile 
            900                 905     


<210> 2262
<211> 33
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<400> 2262
Met Arg Xaa Leu Glu Asp Ser Ser Gly Xaa Val Leu His Arg Leu Ile 
1               5                   10                  15      


Gln Glu Gln Leu Arg Tyr Gly Asn Leu Xaa Glu Xaa Arg Xaa Leu Leu 
            20                  25                  30          


Ala 
    


<210> 2263
<211> 123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<400> 2263
Met Arg Xaa Leu Glu Asp Ser Ser Gly Xaa Val Leu His Arg Leu Ile 
1               5                   10                  15      


Gln Glu Gln Leu Arg Tyr Gly Asn Leu Xaa Glu Xaa Arg Xaa Leu Leu 
            20                  25                  30          


Ala Ile Gln Gln Gln Ala Leu Arg Gly Gly Ala Gly Xaa Gly Gly Xaa 
        35                  40                  45              


Gly Ser Pro Gln Ala Ser Leu Glu Ile Leu Ala Pro Glu Asp Ser Gln 
    50                  55                  60                  


Val Leu Gln Gln Ala Xaa Arg Gln Glu Pro Gln Gly Gln Glu His Gln 
65                  70                  75                  80  


Gly Gly Glu Asn His Leu Ala Glu Asn Xaa Leu Tyr Arg Leu Cys Pro 
                85                  90                  95      


Gln Pro Ser Lys Gly Glu Glu Leu Pro Xaa Tyr Glu Glu Ala Lys Ala 
            100                 105                 110         


His Ser Gln Tyr Tyr Ala Ala Gln Gln Ala Gly 
        115                 120             


<210> 2264
<211> 127
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<400> 2264
Met Arg Xaa Leu Glu Asp Ser Ser Gly Xaa Val Leu His Arg Leu Ile 
1               5                   10                  15      


Gln Glu Gln Leu Arg Tyr Gly Asn Leu Xaa Glu Xaa Arg Xaa Leu Leu 
            20                  25                  30          


Ala Ile Gln Gln Gln Ala Leu Arg Gly Gly Ala Gly Xaa Gly Gly Xaa 
        35                  40                  45              


Gly Ser Pro Gln Ala Ser Leu Glu Ile Leu Ala Pro Glu Asp Ser Gln 
    50                  55                  60                  


Val Leu Gln Gln Ala Xaa Arg Gln Glu Pro Gln Gly Gln Glu His Gln 
65                  70                  75                  80  


Gly Gly Glu Asn His Leu Ala Glu Asn Xaa Leu Tyr Arg Leu Cys Pro 
                85                  90                  95      


Gln Pro Ser Lys Gly Glu Glu Leu Pro Xaa Tyr Glu Glu Ala Lys Ala 
            100                 105                 110         


His Ser Gln Tyr Tyr Ala Ala Gln Gln Ala Gly Xaa Arg Pro His 
        115                 120                 125         


<210> 2265
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<400> 2265
Met Arg Xaa Leu Glu Asp Ser Ser Gly Xaa Val Leu His Arg Leu Ile 
1               5                   10                  15      


Gln Glu Gln Leu Arg Tyr Gly Asn Leu Xaa Glu Xaa Arg Xaa Leu Leu 
            20                  25                  30          


Ala Ile Gln Gln Gln Ala Leu Arg Gly Gly Ala Gly Xaa Gly Gly Xaa 
        35                  40                  45              


Gly Ser Pro Gln Ala Ser Leu Glu Ile Leu Ala Pro Glu Asp Ser Gln 
    50                  55                  60                  


Val Leu Gln Gln Ala Xaa Arg Gln Glu Pro Gln Gly Gln Glu His Gln 
65                  70                  75                  80  


Gly Gly Glu Asn His Leu Ala Glu Asn Xaa Leu Tyr Arg Leu Cys Pro 
                85                  90                  95      


Gln Pro Ser Lys Gly Glu Glu Leu Pro Xaa Tyr Glu Glu Ala Lys Ala 
            100                 105                 110         


His Ser Gln Tyr Tyr Ala Ala Gln Gln Ala Gly Xaa Arg Pro His Ala 
        115                 120                 125             


Gly Asp Arg Asp Pro Arg Gly Ala Pro Gly Gly Ser Arg Arg Gln Asp 
    130                 135                 140                 


<210> 2266
<211> 151
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<400> 2266
Met Arg Xaa Leu Glu Asp Ser Ser Gly Xaa Val Leu His Arg Leu Ile 
1               5                   10                  15      


Gln Glu Gln Leu Arg Tyr Gly Asn Leu Xaa Glu Xaa Arg Xaa Leu Leu 
            20                  25                  30          


Ala Ile Gln Gln Gln Ala Leu Arg Gly Gly Ala Gly Xaa Gly Gly Xaa 
        35                  40                  45              


Gly Ser Pro Gln Ala Ser Leu Glu Ile Leu Ala Pro Glu Asp Ser Gln 
    50                  55                  60                  


Val Leu Gln Gln Ala Xaa Arg Gln Glu Pro Gln Gly Gln Glu His Gln 
65                  70                  75                  80  


Gly Gly Glu Asn His Leu Ala Glu Asn Xaa Leu Tyr Arg Leu Cys Pro 
                85                  90                  95      


Gln Pro Ser Lys Gly Glu Glu Leu Pro Xaa Tyr Glu Glu Ala Lys Ala 
            100                 105                 110         


His Ser Gln Tyr Tyr Ala Ala Gln Gln Ala Gly Xaa Arg Pro His Ala 
        115                 120                 125             


Gly Asp Arg Asp Pro Arg Gly Ala Pro Gly Gly Ser Arg Arg Gln Asp 
    130                 135                 140                 


Glu Ala Leu Arg Glu Leu Arg 
145                 150     


<210> 2267
<211> 198
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<400> 2267
Met Arg Xaa Leu Glu Asp Ser Ser Gly Xaa Val Leu His Arg Leu Ile 
1               5                   10                  15      


Gln Glu Gln Leu Arg Tyr Gly Asn Leu Xaa Glu Xaa Arg Xaa Leu Leu 
            20                  25                  30          


Ala Ile Gln Gln Gln Ala Leu Arg Gly Gly Ala Gly Xaa Gly Gly Xaa 
        35                  40                  45              


Gly Ser Pro Gln Ala Ser Leu Glu Ile Leu Ala Pro Glu Asp Ser Gln 
    50                  55                  60                  


Val Leu Gln Gln Ala Xaa Arg Gln Glu Pro Gln Gly Gln Glu His Gln 
65                  70                  75                  80  


Gly Gly Glu Asn His Leu Ala Glu Asn Xaa Leu Tyr Arg Leu Cys Pro 
                85                  90                  95      


Gln Pro Ser Lys Gly Glu Glu Leu Pro Xaa Tyr Glu Glu Ala Lys Ala 
            100                 105                 110         


His Ser Gln Tyr Tyr Ala Ala Gln Gln Ala Gly Xaa Arg Pro His Ala 
        115                 120                 125             


Gly Asp Arg Asp Pro Arg Gly Ala Pro Gly Gly Ser Arg Arg Gln Asp 
    130                 135                 140                 


Glu Ala Leu Arg Glu Leu Arg His Gly His Val Arg Ser Leu Ser Glu 
145                 150                 155                 160 


Arg Leu Leu Gln Leu Ser Leu Glu Arg Asn Gly Ala Arg Ala Pro Ser 
                165                 170                 175     


His Met Ser Ser Ser His Ser Phe Pro Gln Leu Ala Arg Asn Gln Gln 
            180                 185                 190         


Gly Pro Pro Leu Arg Gly 
        195             


<210> 2268
<211> 777
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<400> 2268
Met Arg Xaa Leu Glu Asp Ser Ser Gly Xaa Val Leu His Arg Leu Ile 
1               5                   10                  15      


Gln Glu Gln Leu Arg Tyr Gly Asn Leu Xaa Glu Xaa Arg Xaa Leu Leu 
            20                  25                  30          


Ala Ile Gln Gln Gln Ala Leu Arg Gly Gly Ala Gly Xaa Gly Gly Xaa 
        35                  40                  45              


Gly Ser Pro Gln Ala Ser Leu Glu Ile Leu Ala Pro Glu Asp Ser Gln 
    50                  55                  60                  


Val Leu Gln Gln Ala Xaa Arg Gln Glu Pro Gln Gly Gln Glu His Gln 
65                  70                  75                  80  


Gly Gly Glu Asn His Leu Ala Glu Asn Xaa Leu Tyr Arg Leu Cys Pro 
                85                  90                  95      


Gln Pro Ser Lys Gly Glu Glu Leu Pro Xaa Tyr Glu Glu Ala Lys Ala 
            100                 105                 110         


His Ser Gln Tyr Tyr Ala Ala Gln Gln Ala Gly Xaa Arg Pro His Ala 
        115                 120                 125             


Gly Asp Arg Asp Pro Arg Gly Ala Pro Gly Gly Ser Arg Arg Gln Asp 
    130                 135                 140                 


Glu Ala Leu Arg Glu Leu Arg His Gly His Val Arg Ser Leu Ser Glu 
145                 150                 155                 160 


Arg Leu Leu Gln Leu Ser Leu Glu Arg Asn Gly Ala Arg Ala Pro Ser 
                165                 170                 175     


His Met Ser Ser Ser His Ser Phe Pro Gln Leu Ala Arg Asn Gln Gln 
            180                 185                 190         


Gly Pro Pro Leu Arg Gly Pro Pro Ala Glu Gly Pro Glu Ser Arg Gly 
        195                 200                 205             


Pro Pro Pro Gln Tyr Pro His Val Val Leu Ala His Glu Xaa Xaa Xaa 
    210                 215                 220                 


Ala Val Xaa Asp Pro Arg Tyr Arg Ala Arg Gly Ser Pro His Phe Gln 
225                 230                 235                 240 


His Ala Glu Val Arg Ile Leu Gln Ala Gln Val Pro Pro Val Phe Leu 
                245                 250                 255     


Gln Gln Gln Gln Gln Tyr Gln Tyr Leu Gln Gln Ser Gln Glu His Pro 
            260                 265                 270         


Pro Pro Pro His Pro Ala Ala Leu Gly His Gly Pro Leu Ser Ser Leu 
        275                 280                 285             


Ser Pro Pro Ala Val Glu Gly Pro Val Ser Ala Gln Ala Ser Ser Ala 
    290                 295                 300                 


Xaa Ser Gly Ser Ala His Leu Ala Gln Met Glu Ala Val Leu Arg Glu 
305                 310                 315                 320 


Asn Ala Arg Leu Gln Arg Asp Asn Glu Arg Leu Gln Arg Glu Leu Glu 
                325                 330                 335     


Ser Ser Ala Glu Lys Ala Gly Arg Ile Glu Lys Leu Glu Ser Glu Ile 
            340                 345                 350         


Gln Arg Leu Ser Glu Ala His Glu Ser Leu Xaa Arg Ala Ser Ser Lys 
        355                 360                 365             


Arg Glu Ala Leu Glu Lys Xaa Met Arg Asn Lys Met Asp Ser Glu Met 
    370                 375                 380                 


Arg Arg Leu Gln Asp Phe Asn Arg Asp Leu Arg Glu Arg Leu Glu Ser 
385                 390                 395                 400 


Ala Asn Arg Arg Leu Ala Ser Lys Xaa Gln Glu Ala Gln Ala Gly Ser 
                405                 410                 415     


Gln Asp Met Val Ala Lys Leu Leu Ala Gln Ser Tyr Glu Gln Gln Gln 
            420                 425                 430         


Glu Gln Glu Lys Leu Glu Arg Glu Met Ala Leu Leu Arg Gly Ala Ile 
        435                 440                 445             


Glu Asp Gln Arg Arg Arg Ala Glu Leu Leu Glu Gln Ala Leu Gly Asn 
    450                 455                 460                 


Ala Gln Gly Arg Ala Ala Arg Ala Glu Glu Glu Leu Arg Lys Lys Gln 
465                 470                 475                 480 


Ala Tyr Val Glu Lys Val Glu Arg Leu Gln Gln Ala Leu Gly Gln Leu 
                485                 490                 495     


Gln Ala Ala Cys Glu Lys Arg Glu Gln Leu Glu Leu Arg Leu Arg Xaa 
            500                 505                 510         


Arg Leu Glu Gln Glu Leu Lys Ala Leu Arg Ala Gln Gln Ala Gly Ala 
        515                 520                 525             


Pro Gly Gly Ser Ser Gly Ser Gly Gly Ser Pro Glu Leu Ser Ala Leu 
    530                 535                 540                 


Arg Leu Ser Glu Gln Leu Arg Glu Lys Glu Glu Gln Ile Leu Ala Leu 
545                 550                 555                 560 


Glu Ala Asp Met Xaa Lys Trp Glu Gln Lys Tyr Leu Glu Glu Arg Ala 
                565                 570                 575     


Met Arg Gln Phe Ala Met Asp Ala Ala Ala Xaa Ala Ala Ala Gln Arg 
            580                 585                 590         


Asp Xaa Xaa Leu Ile Arg His Ser Pro Gln Pro Ser Pro Ser Ser Ser 
        595                 600                 605             


Phe Asn Glu Gly Leu Leu Xaa Gly Gly His Arg His Gln Glu Met Glu 
    610                 615                 620                 


Ser Arg Leu Lys Val Leu His Ala Gln Ile Leu Glu Lys Asp Ala Val 
625                 630                 635                 640 


Ile Lys Val Leu Gln Gln Arg Ser Arg Arg Asp Pro Gly Lys Ala Ile 
                645                 650                 655     


Gln Gly Ser Leu Arg Pro Ala Lys Ser Val Pro Ser Val Phe Ala Ala 
            660                 665                 670         


Ala Ala Ala Gly Xaa Gln Gly Trp Gln Gly Leu Ser Ser Ser Glu Arg 
        675                 680                 685             


Gln Xaa Ala Asp Ala Pro Ala Arg Leu Xaa Xaa Asp Arg Ala Pro Xaa 
    690                 695                 700                 


Glu Glu Pro Val Val Xaa Ala Pro Pro Ala Ala His Ala Lys His Gly 
705                 710                 715                 720 


Ser Arg Asp Gly Ser Xaa Gln Xaa Glu Gly Pro Pro Asp Ser Xaa Ser 
                725                 730                 735     


Xaa Cys Leu Pro Pro Glu Pro Asp Ser Leu Leu Gly Cys Ser Ser Ser 
            740                 745                 750         


Gln Arg Ala Ala Ser Leu Asp Ser Val Ala Xaa Ser Arg Val Gln Asp 
        755                 760                 765             


Leu Ser Asp Met Val Glu Ile Leu Ile 
    770                 775         


<210> 2269
<211> 779
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<400> 2269
Met Arg Xaa Leu Glu Asp Ser Ser Gly Xaa Val Leu His Arg Leu Ile 
1               5                   10                  15      


Gln Glu Gln Leu Arg Tyr Gly Asn Leu Xaa Glu Xaa Arg Xaa Leu Leu 
            20                  25                  30          


Ala Ile Gln Gln Gln Ala Leu Arg Gly Gly Ala Gly Xaa Gly Gly Xaa 
        35                  40                  45              


Gly Ser Pro Gln Ala Ser Leu Glu Ile Leu Ala Pro Glu Asp Ser Gln 
    50                  55                  60                  


Val Leu Gln Gln Ala Xaa Arg Gln Glu Pro Gln Gly Gln Glu His Gln 
65                  70                  75                  80  


Gly Gly Glu Asn His Leu Ala Glu Asn Xaa Leu Tyr Arg Leu Cys Pro 
                85                  90                  95      


Gln Pro Ser Lys Gly Glu Glu Leu Pro Xaa Tyr Glu Glu Ala Lys Ala 
            100                 105                 110         


His Ser Gln Tyr Tyr Ala Ala Gln Gln Ala Gly Xaa Arg Pro His Ala 
        115                 120                 125             


Gly Asp Arg Asp Pro Arg Gly Ala Pro Gly Gly Ser Arg Arg Gln Asp 
    130                 135                 140                 


Glu Ala Leu Arg Glu Leu Arg His Gly His Val Arg Ser Leu Ser Glu 
145                 150                 155                 160 


Arg Leu Leu Gln Leu Ser Leu Glu Arg Asn Gly Ala Arg Ala Pro Ser 
                165                 170                 175     


His Met Ser Ser Ser His Ser Phe Pro Gln Leu Ala Arg Asn Gln Gln 
            180                 185                 190         


Gly Pro Pro Leu Arg Gly Pro Pro Ala Glu Gly Pro Glu Ser Arg Gly 
        195                 200                 205             


Pro Pro Pro Gln Tyr Pro His Val Val Leu Ala His Glu Xaa Xaa Xaa 
    210                 215                 220                 


Ala Val Xaa Asp Pro Arg Tyr Arg Ala Arg Gly Ser Pro His Phe Gln 
225                 230                 235                 240 


His Ala Glu Val Arg Ile Leu Gln Ala Gln Val Pro Pro Val Phe Leu 
                245                 250                 255     


Gln Gln Gln Gln Gln Tyr Gln Tyr Leu Gln Gln Ser Gln Glu His Pro 
            260                 265                 270         


Pro Pro Pro His Pro Ala Ala Leu Gly His Gly Pro Leu Ser Ser Leu 
        275                 280                 285             


Ser Pro Pro Ala Val Glu Gly Pro Val Ser Ala Gln Ala Ser Ser Ala 
    290                 295                 300                 


Xaa Ser Gly Ser Ala His Leu Ala Gln Met Glu Ala Val Leu Arg Glu 
305                 310                 315                 320 


Asn Ala Arg Leu Gln Arg Asp Asn Glu Arg Leu Gln Arg Glu Leu Glu 
                325                 330                 335     


Ser Ser Ala Glu Lys Ala Gly Arg Ile Glu Lys Leu Glu Ser Glu Ile 
            340                 345                 350         


Gln Arg Leu Ser Glu Ala His Glu Ser Leu Xaa Arg Ala Ser Ser Lys 
        355                 360                 365             


Arg Glu Ala Leu Glu Lys Xaa Met Arg Asn Lys Met Asp Ser Glu Met 
    370                 375                 380                 


Arg Arg Leu Gln Asp Phe Asn Arg Asp Leu Arg Glu Arg Leu Glu Ser 
385                 390                 395                 400 


Ala Asn Arg Arg Leu Ala Ser Lys Xaa Gln Glu Ala Gln Ala Gly Ser 
                405                 410                 415     


Gln Asp Met Val Ala Lys Leu Leu Ala Gln Ser Tyr Glu Gln Gln Gln 
            420                 425                 430         


Glu Gln Glu Lys Leu Glu Arg Glu Met Ala Leu Leu Arg Gly Ala Ile 
        435                 440                 445             


Glu Asp Gln Arg Arg Arg Ala Glu Leu Leu Glu Gln Ala Leu Gly Asn 
    450                 455                 460                 


Ala Gln Gly Arg Ala Ala Arg Ala Glu Glu Glu Leu Arg Lys Lys Gln 
465                 470                 475                 480 


Ala Tyr Val Glu Lys Val Glu Arg Leu Gln Gln Ala Leu Gly Gln Leu 
                485                 490                 495     


Gln Ala Ala Cys Glu Lys Arg Glu Gln Leu Glu Leu Arg Leu Arg Xaa 
            500                 505                 510         


Arg Leu Glu Gln Glu Leu Lys Ala Leu Arg Ala Gln Gln Arg Gln Ala 
        515                 520                 525             


Gly Ala Pro Gly Gly Ser Ser Gly Ser Gly Gly Ser Pro Glu Leu Ser 
    530                 535                 540                 


Ala Leu Arg Leu Ser Glu Gln Leu Arg Glu Lys Glu Glu Gln Ile Leu 
545                 550                 555                 560 


Ala Leu Glu Ala Asp Met Xaa Lys Trp Glu Gln Lys Tyr Leu Glu Glu 
                565                 570                 575     


Arg Ala Met Arg Gln Phe Ala Met Asp Ala Ala Ala Xaa Ala Ala Ala 
            580                 585                 590         


Gln Arg Asp Xaa Xaa Leu Ile Arg His Ser Pro Gln Pro Ser Pro Ser 
        595                 600                 605             


Ser Ser Phe Asn Glu Gly Leu Leu Xaa Gly Gly His Arg His Gln Glu 
    610                 615                 620                 


Met Glu Ser Arg Leu Lys Val Leu His Ala Gln Ile Leu Glu Lys Asp 
625                 630                 635                 640 


Ala Val Ile Lys Val Leu Gln Gln Arg Ser Arg Arg Asp Pro Gly Lys 
                645                 650                 655     


Ala Ile Gln Gly Ser Leu Arg Pro Ala Lys Ser Val Pro Ser Val Phe 
            660                 665                 670         


Ala Ala Ala Ala Ala Gly Xaa Gln Gly Trp Gln Gly Leu Ser Ser Ser 
        675                 680                 685             


Glu Arg Gln Xaa Ala Asp Ala Pro Ala Arg Leu Xaa Xaa Asp Arg Ala 
    690                 695                 700                 


Pro Xaa Glu Glu Pro Val Val Xaa Ala Pro Pro Ala Ala His Ala Lys 
705                 710                 715                 720 


His Gly Ser Arg Asp Gly Ser Xaa Gln Xaa Glu Gly Pro Pro Asp Ser 
                725                 730                 735     


Xaa Ser Xaa Cys Leu Pro Pro Glu Pro Asp Ser Leu Leu Gly Cys Ser 
            740                 745                 750         


Ser Ser Gln Arg Ala Ala Ser Leu Asp Ser Val Ala Xaa Ser Arg Val 
        755                 760                 765             


Gln Asp Leu Ser Asp Met Val Glu Ile Leu Ile 
    770                 775                 


<210> 2270
<211> 780
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<400> 2270
Met Arg Xaa Leu Glu Asp Ser Ser Gly Xaa Val Leu His Arg Leu Ile 
1               5                   10                  15      


Gln Glu Gln Leu Arg Tyr Gly Asn Leu Xaa Glu Xaa Arg Xaa Leu Leu 
            20                  25                  30          


Ala Ile Gln Gln Gln Ala Leu Arg Gly Gly Ala Gly Xaa Gly Gly Xaa 
        35                  40                  45              


Gly Ser Pro Gln Ala Ser Leu Glu Ile Leu Ala Pro Glu Asp Ser Gln 
    50                  55                  60                  


Val Leu Gln Gln Ala Xaa Arg Gln Glu Pro Gln Gly Gln Glu His Gln 
65                  70                  75                  80  


Gly Gly Glu Asn His Leu Ala Glu Asn Xaa Leu Tyr Arg Leu Cys Pro 
                85                  90                  95      


Gln Pro Ser Lys Gly Glu Glu Leu Pro Xaa Tyr Glu Glu Ala Lys Ala 
            100                 105                 110         


His Ser Gln Tyr Tyr Ala Ala Gln Gln Ala Gly Xaa Arg Pro His Ala 
        115                 120                 125             


Gly Asp Arg Asp Pro Arg Gly Ala Pro Gly Gly Ser Arg Arg Gln Asp 
    130                 135                 140                 


Glu Ala Leu Arg Glu Leu Arg His Gly His Val Arg Ser Leu Ser Glu 
145                 150                 155                 160 


Arg Leu Leu Gln Leu Ser Leu Glu Arg Asn Gly Ala Arg Ala Pro Ser 
                165                 170                 175     


His Met Ser Ser Ser His Ser Phe Pro Gln Leu Ala Arg Asn Gln Gln 
            180                 185                 190         


Gly Pro Pro Leu Arg Gly Pro Pro Ala Glu Gly Pro Glu Ser Arg Gly 
        195                 200                 205             


Pro Pro Pro Gln Tyr Pro His Val Val Leu Ala His Glu Xaa Xaa Xaa 
    210                 215                 220                 


Ala Val Xaa Asp Pro Arg Tyr Arg Ala Arg Gly Ser Pro His Phe Gln 
225                 230                 235                 240 


His Ala Glu Val Arg Ile Leu Gln Ala Gln Val Pro Pro Val Phe Leu 
                245                 250                 255     


Gln Gln Gln Gln Gln Tyr Gln Tyr Leu Gln Gln Ser Gln Glu His Pro 
            260                 265                 270         


Pro Pro Pro His Pro Ala Ala Leu Gly His Gly Pro Leu Ser Ser Leu 
        275                 280                 285             


Ser Pro Pro Ala Val Glu Gly Pro Val Ser Ala Gln Ala Ser Ser Ala 
    290                 295                 300                 


Xaa Ser Gly Ser Ala His Leu Ala Gln Met Glu Ala Val Leu Arg Glu 
305                 310                 315                 320 


Asn Ala Arg Leu Gln Arg Asp Asn Glu Arg Leu Gln Arg Glu Leu Glu 
                325                 330                 335     


Ser Ser Ala Glu Lys Ala Gly Arg Ile Glu Lys Leu Glu Ser Glu Ile 
            340                 345                 350         


Gln Arg Leu Ser Glu Ala His Glu Ser Leu Xaa Arg Ala Ser Ser Lys 
        355                 360                 365             


Arg Glu Ala Leu Glu Lys Xaa Met Arg Asn Lys Met Asp Ser Glu Met 
    370                 375                 380                 


Arg Arg Leu Gln Asp Phe Asn Arg Asp Leu Arg Glu Arg Leu Glu Ser 
385                 390                 395                 400 


Ala Asn Arg Arg Leu Ala Ser Lys Xaa Gln Glu Ala Gln Ala Gly Ser 
                405                 410                 415     


Gln Asp Met Val Ala Lys Leu Leu Ala Gln Ser Tyr Glu Gln Gln Gln 
            420                 425                 430         


Glu Gln Glu Lys Leu Glu Arg Glu Met Ala Leu Leu Arg Gly Ala Ile 
        435                 440                 445             


Glu Asp Gln Arg Arg Arg Ala Glu Leu Leu Glu Gln Ala Leu Gly Asn 
    450                 455                 460                 


Ala Gln Gly Arg Ala Ala Arg Ala Glu Glu Glu Leu Arg Lys Lys Gln 
465                 470                 475                 480 


Ala Tyr Val Glu Lys Val Glu Arg Leu Gln Gln Ala Leu Gly Gln Leu 
                485                 490                 495     


Gln Ala Ala Cys Glu Lys Arg Glu Gln Leu Glu Leu Arg Leu Arg Xaa 
            500                 505                 510         


Arg Leu Glu Gln Glu Leu Lys Ala Leu Arg Ala Gln Gln Arg Gln Ala 
        515                 520                 525             


Gly Ala Pro Gly Gly Ser Ser Gly Ser Gly Gly Ser Pro Glu Leu Ser 
    530                 535                 540                 


Ala Leu Arg Leu Ser Glu Gln Leu Arg Glu Lys Glu Glu Gln Ile Leu 
545                 550                 555                 560 


Ala Leu Glu Ala Asp Met Xaa Lys Trp Glu Gln Lys Tyr Leu Glu Glu 
                565                 570                 575     


Arg Ala Met Arg Gln Phe Ala Met Asp Ala Ala Ala Xaa Ala Ala Ala 
            580                 585                 590         


Gln Arg Asp Xaa Xaa Leu Ile Arg His Ser Pro Gln Pro Ser Pro Ser 
        595                 600                 605             


Ser Ser Phe Asn Glu Gly Leu Leu Xaa Gly Gly His Arg His Gln Glu 
    610                 615                 620                 


Met Glu Ser Arg Leu Lys Val Leu His Ala Gln Ile Leu Glu Lys Asp 
625                 630                 635                 640 


Ala Val Ile Lys Val Leu Gln Gln Arg Ser Arg Arg Asp Pro Gly Lys 
                645                 650                 655     


Ala Ile Gln Gly Ser Leu Arg Pro Ala Lys Ser Val Pro Ser Val Phe 
            660                 665                 670         


Ala Ala Ala Ala Ala Gly Xaa Gln Gly Trp Gln Gly Leu Ser Ser Ser 
        675                 680                 685             


Glu Arg Gln Xaa Ala Asp Ala Pro Ala Arg Leu Xaa Xaa Ala Asp Arg 
    690                 695                 700                 


Ala Pro Xaa Glu Glu Pro Val Val Xaa Ala Pro Pro Ala Ala His Ala 
705                 710                 715                 720 


Lys His Gly Ser Arg Asp Gly Ser Xaa Gln Xaa Glu Gly Pro Pro Asp 
                725                 730                 735     


Ser Xaa Ser Xaa Cys Leu Pro Pro Glu Pro Asp Ser Leu Leu Gly Cys 
            740                 745                 750         


Ser Ser Ser Gln Arg Ala Ala Ser Leu Asp Ser Val Ala Xaa Ser Arg 
        755                 760                 765             


Val Gln Asp Leu Ser Asp Met Val Glu Ile Leu Ile 
    770                 775                 780 


<210> 2271
<211> 837
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<400> 2271
Met Xaa Gly Arg Lys Ala Ser Gly Gly Xaa Pro Cys Xaa Leu Arg Lys 
1               5                   10                  15      


Gly Ala Pro Ile Ile Xaa Leu Gly Lys Asn Trp Xaa Glu Arg Leu Ala 
            20                  25                  30          


Ala Gly Asp Ser Val Gly Cys Ser Gly Ala Arg Cys His Arg Pro Leu 
        35                  40                  45              


Ser Arg Gln Leu Cys Ala Ser Gln Arg Ser Met Arg Xaa Leu Glu Asp 
    50                  55                  60                  


Ser Ser Gly Xaa Val Leu His Arg Leu Ile Gln Glu Gln Leu Arg Tyr 
65                  70                  75                  80  


Gly Asn Leu Xaa Glu Xaa Arg Xaa Leu Leu Ala Ile Gln Gln Gln Ala 
                85                  90                  95      


Leu Arg Gly Gly Ala Gly Xaa Gly Gly Xaa Gly Ser Pro Gln Ala Ser 
            100                 105                 110         


Leu Glu Ile Leu Ala Pro Glu Asp Ser Gln Val Leu Gln Gln Ala Xaa 
        115                 120                 125             


Arg Gln Glu Pro Gln Gly Gln Glu His Gln Gly Gly Glu Asn His Leu 
    130                 135                 140                 


Ala Glu Asn Xaa Leu Tyr Arg Leu Cys Pro Gln Pro Ser Lys Gly Glu 
145                 150                 155                 160 


Glu Leu Pro Xaa Tyr Glu Glu Ala Lys Ala His Ser Gln Tyr Tyr Ala 
                165                 170                 175     


Ala Gln Gln Ala Gly Xaa Arg Pro His Ala Gly Asp Arg Asp Pro Arg 
            180                 185                 190         


Gly Ala Pro Gly Gly Ser Arg Arg Gln Asp Glu Ala Leu Arg Glu Leu 
        195                 200                 205             


Arg His Gly His Val Arg Ser Leu Ser Glu Arg Leu Leu Gln Leu Ser 
    210                 215                 220                 


Leu Glu Arg Asn Gly Ala Arg Ala Pro Ser His Met Ser Ser Ser His 
225                 230                 235                 240 


Ser Phe Pro Gln Leu Ala Arg Asn Gln Gln Gly Pro Pro Leu Arg Gly 
                245                 250                 255     


Pro Pro Ala Glu Gly Pro Glu Ser Arg Gly Pro Pro Pro Gln Tyr Pro 
            260                 265                 270         


His Val Val Leu Ala His Glu Xaa Xaa Xaa Ala Val Xaa Asp Pro Arg 
        275                 280                 285             


Tyr Arg Ala Arg Gly Ser Pro His Phe Gln His Ala Glu Val Arg Ile 
    290                 295                 300                 


Leu Gln Ala Gln Val Pro Pro Val Phe Leu Gln Gln Gln Gln Gln Tyr 
305                 310                 315                 320 


Gln Tyr Leu Gln Gln Ser Gln Glu His Pro Pro Pro Pro His Pro Ala 
                325                 330                 335     


Ala Leu Gly His Gly Pro Leu Ser Ser Leu Ser Pro Pro Ala Val Glu 
            340                 345                 350         


Gly Pro Val Ser Ala Gln Ala Ser Ser Ala Xaa Ser Gly Ser Ala His 
        355                 360                 365             


Leu Ala Gln Met Glu Ala Val Leu Arg Glu Asn Ala Arg Leu Gln Arg 
    370                 375                 380                 


Asp Asn Glu Arg Leu Gln Arg Glu Leu Glu Ser Ser Ala Glu Lys Ala 
385                 390                 395                 400 


Gly Arg Ile Glu Lys Leu Glu Ser Glu Ile Gln Arg Leu Ser Glu Ala 
                405                 410                 415     


His Glu Ser Leu Xaa Arg Ala Ser Ser Lys Arg Glu Ala Leu Glu Lys 
            420                 425                 430         


Xaa Met Arg Asn Lys Met Asp Ser Glu Met Arg Arg Leu Gln Asp Phe 
        435                 440                 445             


Asn Arg Asp Leu Arg Glu Arg Leu Glu Ser Ala Asn Arg Arg Leu Ala 
    450                 455                 460                 


Ser Lys Xaa Gln Glu Ala Gln Ala Gly Ser Gln Asp Met Val Ala Lys 
465                 470                 475                 480 


Leu Leu Ala Gln Ser Tyr Glu Gln Gln Gln Glu Gln Glu Lys Leu Glu 
                485                 490                 495     


Arg Glu Met Ala Leu Leu Arg Gly Ala Ile Glu Asp Gln Arg Arg Arg 
            500                 505                 510         


Ala Glu Leu Leu Glu Gln Ala Leu Gly Asn Ala Gln Gly Arg Ala Ala 
        515                 520                 525             


Arg Ala Glu Glu Glu Leu Arg Lys Lys Gln Ala Tyr Val Glu Lys Val 
    530                 535                 540                 


Glu Arg Leu Gln Gln Ala Leu Gly Gln Leu Gln Ala Ala Cys Glu Lys 
545                 550                 555                 560 


Arg Glu Gln Leu Glu Leu Arg Leu Arg Xaa Arg Leu Glu Gln Glu Leu 
                565                 570                 575     


Lys Ala Leu Arg Ala Gln Gln Arg Gln Ala Gly Ala Pro Gly Gly Ser 
            580                 585                 590         


Ser Gly Ser Gly Gly Ser Pro Glu Leu Ser Ala Leu Arg Leu Ser Glu 
        595                 600                 605             


Gln Leu Arg Glu Lys Glu Glu Gln Ile Leu Ala Leu Glu Ala Asp Met 
    610                 615                 620                 


Xaa Lys Trp Glu Gln Lys Tyr Leu Glu Glu Arg Ala Met Arg Gln Phe 
625                 630                 635                 640 


Ala Met Asp Ala Ala Ala Xaa Ala Ala Ala Gln Arg Asp Xaa Xaa Leu 
                645                 650                 655     


Ile Arg His Ser Pro Gln Pro Ser Pro Ser Ser Ser Phe Asn Glu Gly 
            660                 665                 670         


Leu Leu Xaa Gly Gly His Arg His Gln Glu Met Glu Ser Arg Leu Lys 
        675                 680                 685             


Val Leu His Ala Gln Ile Leu Glu Lys Asp Ala Val Ile Lys Val Leu 
    690                 695                 700                 


Gln Gln Arg Ser Arg Arg Asp Pro Gly Lys Ala Ile Gln Gly Ser Leu 
705                 710                 715                 720 


Arg Pro Ala Lys Ser Val Pro Ser Val Phe Ala Ala Ala Ala Ala Gly 
                725                 730                 735     


Xaa Gln Gly Trp Gln Gly Leu Ser Ser Ser Glu Arg Gln Xaa Ala Asp 
            740                 745                 750         


Ala Pro Ala Arg Leu Xaa Xaa Asp Arg Ala Pro Xaa Glu Glu Pro Val 
        755                 760                 765             


Val Xaa Ala Pro Pro Ala Ala His Ala Lys His Gly Ser Arg Asp Gly 
    770                 775                 780                 


Ser Xaa Gln Xaa Glu Gly Pro Pro Asp Ser Xaa Ser Xaa Cys Leu Pro 
785                 790                 795                 800 


Pro Glu Pro Asp Ser Leu Leu Gly Cys Ser Ser Ser Gln Arg Ala Ala 
                805                 810                 815     


Ser Leu Asp Ser Val Ala Xaa Ser Arg Val Gln Asp Leu Ser Asp Met 
            820                 825                 830         


Val Glu Ile Leu Ile 
        835         


<210> 2272
<211> 298
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(290)
<223> Selenocysteine

<400> 2272
Met Glu Gly Lys His Lys Glu Glu Leu Asp Xaa Leu Lys Glu Glu Lys 
1               5                   10                  15      


Glu Asn Leu Gln Gly Leu Val Xaa Arg Gln Xaa Tyr Ile Ile Gln Glu 
            20                  25                  30          


Leu Glu Lys Gln Leu Asn Arg Ala Xaa Xaa Asn Asn Ser Val Leu Gln 
        35                  40                  45              


Lys Gln Gln Leu Glu Leu Met Asp Xaa Val His Asn Leu Val Asn Leu 
    50                  55                  60                  


Cys Xaa Lys Glu Gly Val Leu Leu Lys Gly Gly Lys Arg Glu Glu Glu 
65                  70                  75                  80  


Lys Pro Phe Arg Asp Cys Ala Asp Val Tyr Gln Ala Gly Phe Asn Lys 
                85                  90                  95      


Ser Gly Ile Tyr Xaa Ile Tyr Ile Asn Asn Met Pro Glu Pro Lys Lys 
            100                 105                 110         


Val Phe Cys Asn Met Asp Val Asn Gly Gly Gly Trp Xaa Val Ile Gln 
        115                 120                 125             


His Arg Glu Asp Gly Ser Leu Asp Phe Gln Arg Gly Trp Lys Glu Tyr 
    130                 135                 140                 


Lys Met Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu 
145                 150                 155                 160 


Phe Ile Phe Ala Ile Xaa Ser Gln Arg Gln Tyr Met Leu Arg Ile Glu 
                165                 170                 175     


Leu Met Asp Trp Glu Gly Asn Arg Ala Tyr Ser Gln Tyr Asp Arg Phe 
            180                 185                 190         


His Ile Gly Asn Glu Lys Gln Asn Tyr Arg Leu Tyr Leu Lys Gly His 
        195                 200                 205             


Xaa Gly Xaa Ala Gly Lys Gln Ser Ser Leu Ile Leu His Gly Ala Asp 
    210                 215                 220                 


Phe Ser Xaa Lys Asp Ala Asp Asn Asp Asn Cys Met Cys Lys Cys Ala 
225                 230                 235                 240 


Leu Met Leu Xaa Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn 
                245                 250                 255     


Leu Asn Gly Met Phe Tyr Xaa Ala Gly Gln Asn His Gly Lys Leu Asn 
            260                 265                 270         


Gly Ile Lys Trp His Tyr Phe Lys Gly Pro Ser Tyr Ser Leu Arg Ser 
        275                 280                 285             


Xaa Xaa Met Met Ile Arg Pro Leu Asp Phe 
    290                 295             


<210> 2273
<211> 297
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(289)
<223> Selenocysteine

<400> 2273
Met Glu Gly Lys His Lys Glu Glu Leu Asp Xaa Leu Lys Glu Glu Lys 
1               5                   10                  15      


Glu Asn Leu Gln Gly Leu Val Xaa Arg Gln Xaa Tyr Ile Ile Gln Glu 
            20                  25                  30          


Leu Glu Lys Gln Leu Asn Arg Ala Xaa Xaa Asn Asn Ser Val Leu Gln 
        35                  40                  45              


Lys Gln Gln Leu Glu Leu Met Asp Xaa Val His Asn Leu Val Asn Leu 
    50                  55                  60                  


Cys Xaa Lys Glu Val Leu Leu Lys Gly Gly Lys Arg Glu Glu Glu Lys 
65                  70                  75                  80  


Pro Phe Arg Asp Cys Ala Asp Val Tyr Gln Ala Gly Phe Asn Lys Ser 
                85                  90                  95      


Gly Ile Tyr Xaa Ile Tyr Ile Asn Asn Met Pro Glu Pro Lys Lys Val 
            100                 105                 110         


Phe Cys Asn Met Asp Val Asn Gly Gly Gly Trp Xaa Val Ile Gln His 
        115                 120                 125             


Arg Glu Asp Gly Ser Leu Asp Phe Gln Arg Gly Trp Lys Glu Tyr Lys 
    130                 135                 140                 


Met Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe 
145                 150                 155                 160 


Ile Phe Ala Ile Xaa Ser Gln Arg Gln Tyr Met Leu Arg Ile Glu Leu 
                165                 170                 175     


Met Asp Trp Glu Gly Asn Arg Ala Tyr Ser Gln Tyr Asp Arg Phe His 
            180                 185                 190         


Ile Gly Asn Glu Lys Gln Asn Tyr Arg Leu Tyr Leu Lys Gly His Xaa 
        195                 200                 205             


Gly Xaa Ala Gly Lys Gln Ser Ser Leu Ile Leu His Gly Ala Asp Phe 
    210                 215                 220                 


Ser Xaa Lys Asp Ala Asp Asn Asp Asn Cys Met Cys Lys Cys Ala Leu 
225                 230                 235                 240 


Met Leu Xaa Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                245                 250                 255     


Asn Gly Met Phe Tyr Xaa Ala Gly Gln Asn His Gly Lys Leu Asn Gly 
            260                 265                 270         


Ile Lys Trp His Tyr Phe Lys Gly Pro Ser Tyr Ser Leu Arg Ser Xaa 
        275                 280                 285             


Xaa Met Met Ile Arg Pro Leu Asp Phe 
    290                 295         


<210> 2274
<211> 30
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<400> 2274
Met Lys Ser Glu Met Ala Gln Ile Gln Gln Asn Ala Val Gln Asn His 
1               5                   10                  15      


Xaa Ala Xaa Met Leu Glu Ile Gly Xaa Ser Leu Leu Ser Gln 
            20                  25                  30  


<210> 2275
<211> 497
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(489)
<223> Selenocysteine

<400> 2275
Met Xaa Val Phe Leu Ser Phe Ala Phe Leu Ala Ala Ile Leu Xaa His 
1               5                   10                  15      


Ile Gly Cys Ser Asn Gln Arg Arg Ser Pro Glu Asn Ser Gly Arg Arg 
            20                  25                  30          


Tyr Asn Arg Ile Gln His Gly Gln Cys Ala Tyr Xaa Phe Ile Leu Pro 
        35                  40                  45              


Glu His Asp Gly Asn Cys Arg Glu Ser Xaa Xaa Asp Gln Tyr Asn Xaa 
    50                  55                  60                  


Asn Ala Leu Gln Arg Asp Ala Pro His Val Glu Pro Asp Phe Ser Ser 
65                  70                  75                  80  


Gln Lys Leu Gln His Leu Glu His Val Met Glu Asn Tyr Xaa Gln Trp 
                85                  90                  95      


Leu Gln Lys Leu Glu Asn Tyr Ile Val Glu Asn Met Lys Ser Glu Met 
            100                 105                 110         


Ala Gln Ile Gln Gln Asn Ala Val Gln Asn His Xaa Ala Xaa Met Leu 
        115                 120                 125             


Glu Ile Gly Xaa Ser Leu Leu Ser Gln Xaa Ala Glu Gln Xaa Arg Lys 
    130                 135                 140                 


Leu Xaa Asp Val Glu Xaa Gln Val Leu Asn Gln Xaa Ser Arg Leu Glu 
145                 150                 155                 160 


Ile Gln Leu Leu Glu Asn Ser Leu Ser Xaa Tyr Lys Leu Glu Lys Gln 
                165                 170                 175     


Leu Leu Gln Gln Xaa Asn Glu Ile Leu Lys Ile His Glu Lys Asn Ser 
            180                 185                 190         


Leu Leu Glu His Lys Ile Leu Glu Met Glu Gly Lys His Lys Glu Glu 
        195                 200                 205             


Leu Asp Xaa Leu Lys Glu Glu Lys Glu Asn Leu Gln Gly Leu Val Xaa 
    210                 215                 220                 


Arg Gln Xaa Tyr Ile Ile Gln Glu Leu Glu Lys Gln Leu Asn Arg Ala 
225                 230                 235                 240 


Xaa Xaa Asn Asn Ser Val Leu Gln Lys Gln Gln Leu Glu Leu Met Asp 
                245                 250                 255     


Xaa Val His Asn Leu Val Asn Leu Cys Xaa Lys Glu Val Leu Leu Lys 
            260                 265                 270         


Gly Gly Lys Arg Glu Glu Glu Lys Pro Phe Arg Asp Cys Ala Asp Val 
        275                 280                 285             


Tyr Gln Ala Gly Phe Asn Lys Ser Gly Ile Tyr Xaa Ile Tyr Ile Asn 
    290                 295                 300                 


Asn Met Pro Glu Pro Lys Lys Val Phe Cys Asn Met Asp Val Asn Gly 
305                 310                 315                 320 


Gly Gly Trp Xaa Val Ile Gln His Arg Glu Asp Gly Ser Leu Asp Phe 
                325                 330                 335     


Gln Arg Gly Trp Lys Glu Tyr Lys Met Gly Phe Gly Asn Pro Ser Gly 
            340                 345                 350         


Glu Tyr Trp Leu Gly Asn Glu Phe Ile Phe Ala Ile Xaa Ser Gln Arg 
        355                 360                 365             


Gln Tyr Met Leu Arg Ile Glu Leu Met Asp Trp Glu Gly Asn Arg Ala 
    370                 375                 380                 


Tyr Ser Gln Tyr Asp Arg Phe His Ile Gly Asn Glu Lys Gln Asn Tyr 
385                 390                 395                 400 


Arg Leu Tyr Leu Lys Gly His Xaa Gly Xaa Ala Gly Lys Gln Ser Ser 
                405                 410                 415     


Leu Ile Leu His Gly Ala Asp Phe Ser Xaa Lys Asp Ala Asp Asn Asp 
            420                 425                 430         


Asn Cys Met Cys Lys Cys Ala Leu Met Leu Xaa Gly Gly Trp Trp Phe 
        435                 440                 445             


Asp Ala Cys Gly Pro Ser Asn Leu Asn Gly Met Phe Tyr Xaa Ala Gly 
    450                 455                 460                 


Gln Asn His Gly Lys Leu Asn Gly Ile Lys Trp His Tyr Phe Lys Gly 
465                 470                 475                 480 


Pro Ser Tyr Ser Leu Arg Ser Xaa Xaa Met Met Ile Arg Pro Leu Asp 
                485                 490                 495     


Phe 
    


<210> 2276
<211> 498
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(490)
<223> Selenocysteine

<400> 2276
Met Xaa Val Phe Leu Ser Phe Ala Phe Leu Ala Ala Ile Leu Xaa His 
1               5                   10                  15      


Ile Gly Cys Ser Asn Gln Arg Arg Ser Pro Glu Asn Ser Gly Arg Arg 
            20                  25                  30          


Tyr Asn Arg Ile Gln His Gly Gln Cys Ala Tyr Xaa Phe Ile Leu Pro 
        35                  40                  45              


Glu His Asp Gly Asn Cys Arg Glu Ser Xaa Xaa Asp Gln Tyr Asn Xaa 
    50                  55                  60                  


Asn Ala Leu Gln Arg Asp Ala Pro His Val Glu Pro Asp Phe Ser Ser 
65                  70                  75                  80  


Gln Lys Leu Gln His Leu Glu His Val Met Glu Asn Tyr Xaa Gln Trp 
                85                  90                  95      


Leu Gln Lys Leu Glu Asn Tyr Ile Val Glu Asn Met Lys Ser Glu Met 
            100                 105                 110         


Ala Gln Ile Gln Gln Asn Ala Val Gln Asn His Xaa Ala Xaa Met Leu 
        115                 120                 125             


Glu Ile Gly Xaa Ser Leu Leu Ser Gln Xaa Ala Glu Gln Xaa Arg Lys 
    130                 135                 140                 


Leu Xaa Asp Val Glu Xaa Gln Val Leu Asn Gln Xaa Ser Arg Leu Glu 
145                 150                 155                 160 


Ile Gln Leu Leu Glu Asn Ser Leu Ser Xaa Tyr Lys Leu Glu Lys Gln 
                165                 170                 175     


Leu Leu Gln Gln Xaa Asn Glu Ile Leu Lys Ile His Glu Lys Asn Ser 
            180                 185                 190         


Leu Leu Glu His Lys Ile Leu Glu Met Glu Gly Lys His Lys Glu Glu 
        195                 200                 205             


Leu Asp Xaa Leu Lys Glu Glu Lys Glu Asn Leu Gln Gly Leu Val Xaa 
    210                 215                 220                 


Arg Gln Xaa Tyr Ile Ile Gln Glu Leu Glu Lys Gln Leu Asn Arg Ala 
225                 230                 235                 240 


Xaa Xaa Asn Asn Ser Val Leu Gln Lys Gln Gln Leu Glu Leu Met Asp 
                245                 250                 255     


Xaa Val His Asn Leu Val Asn Leu Cys Xaa Lys Glu Gly Val Leu Leu 
            260                 265                 270         


Lys Gly Gly Lys Arg Glu Glu Glu Lys Pro Phe Arg Asp Cys Ala Asp 
        275                 280                 285             


Val Tyr Gln Ala Gly Phe Asn Lys Ser Gly Ile Tyr Xaa Ile Tyr Ile 
    290                 295                 300                 


Asn Asn Met Pro Glu Pro Lys Lys Val Phe Cys Asn Met Asp Val Asn 
305                 310                 315                 320 


Gly Gly Gly Trp Xaa Val Ile Gln His Arg Glu Asp Gly Ser Leu Asp 
                325                 330                 335     


Phe Gln Arg Gly Trp Lys Glu Tyr Lys Met Gly Phe Gly Asn Pro Ser 
            340                 345                 350         


Gly Glu Tyr Trp Leu Gly Asn Glu Phe Ile Phe Ala Ile Xaa Ser Gln 
        355                 360                 365             


Arg Gln Tyr Met Leu Arg Ile Glu Leu Met Asp Trp Glu Gly Asn Arg 
    370                 375                 380                 


Ala Tyr Ser Gln Tyr Asp Arg Phe His Ile Gly Asn Glu Lys Gln Asn 
385                 390                 395                 400 


Tyr Arg Leu Tyr Leu Lys Gly His Xaa Gly Xaa Ala Gly Lys Gln Ser 
                405                 410                 415     


Ser Leu Ile Leu His Gly Ala Asp Phe Ser Xaa Lys Asp Ala Asp Asn 
            420                 425                 430         


Asp Asn Cys Met Cys Lys Cys Ala Leu Met Leu Xaa Gly Gly Trp Trp 
        435                 440                 445             


Phe Asp Ala Cys Gly Pro Ser Asn Leu Asn Gly Met Phe Tyr Xaa Ala 
    450                 455                 460                 


Gly Gln Asn His Gly Lys Leu Asn Gly Ile Lys Trp His Tyr Phe Lys 
465                 470                 475                 480 


Gly Pro Ser Tyr Ser Leu Arg Ser Xaa Xaa Met Met Ile Arg Pro Leu 
                485                 490                 495     


Asp Phe 
        


<210> 2277
<211> 459
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<400> 2277
Met Trp Gln Ile Val Phe Phe Xaa Leu Ser Cys Asp Leu Val Leu Ala 
1               5                   10                  15      


Ala Ala Tyr Asn Asn Phe Arg Lys Ser Met Asp Ser Ile Gly Lys Lys 
            20                  25                  30          


Gln Tyr Gln Val Gln His Gly Ser Cys Ser Tyr Xaa Phe Leu Leu Pro 
        35                  40                  45              


Glu Met Asp Asn Cys Arg Ser Ser Ser Ser Pro Tyr Val Ser Asn Ala 
    50                  55                  60                  


Val Gln Arg Asp Ala Pro Leu Glu Tyr Asp Asp Ser Val Gln Arg Leu 
65                  70                  75                  80  


Gln Val Leu Glu Asn Ile Met Glu Asn Asn Xaa Gln Trp Leu Met Lys 
                85                  90                  95      


Leu Glu Asn Tyr Ile Gln Asp Asn Met Lys Lys Glu Met Val Glu Ile 
            100                 105                 110         


Gln Gln Asn Ala Val Gln Asn Gln Xaa Ala Val Met Ile Glu Ile Gly 
        115                 120                 125             


Xaa Asn Leu Leu Asn Gln Xaa Ala Glu Gln Xaa Arg Lys Leu Xaa Asp 
    130                 135                 140                 


Val Glu Ala Gln Val Leu Asn Gln Xaa Xaa Arg Leu Glu Leu Gln Leu 
145                 150                 155                 160 


Leu Glu His Ser Leu Ser Xaa Asn Lys Leu Glu Lys Gln Ile Leu Asp 
                165                 170                 175     


Gln Xaa Ser Glu Ile Asn Lys Leu Gln Asp Lys Asn Ser Phe Leu Glu 
            180                 185                 190         


Lys Lys Val Leu Ala Met Glu Asp Lys His Ile Ile Gln Leu Gln Ser 
        195                 200                 205             


Ile Lys Glu Glu Lys Asp Gln Leu Gln Val Leu Val Ser Lys Gln Asn 
    210                 215                 220                 


Ser Ile Ile Glu Glu Leu Glu Lys Lys Ile Val Xaa Ala Xaa Val Asn 
225                 230                 235                 240 


Asn Ser Val Leu Gln Lys Gln Gln His Asp Leu Met Glu Xaa Val Asn 
                245                 250                 255     


Asn Leu Leu Xaa Met Met Ser Xaa Ser Asn Ser Lys Asp Pro Xaa Val 
            260                 265                 270         


Ala Lys Glu Glu Gln Ile Ser Phe Arg Asp Cys Ala Glu Val Phe Lys 
        275                 280                 285             


Ser Gly His Xaa Xaa Asn Gly Ile Tyr Xaa Leu Xaa Phe Pro Asn Ser 
    290                 295                 300                 


Xaa Glu Glu Ile Lys Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly 
305                 310                 315                 320 


Trp Xaa Ile Ile Gln Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg 
                325                 330                 335     


Xaa Trp Lys Glu Tyr Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr 
            340                 345                 350         


Trp Leu Gly Asn Glu Phe Val Ser Gln Leu Xaa Asn Gln Gln Arg Tyr 
        355                 360                 365             


Val Leu Lys Ile His Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser 
    370                 375                 380                 


Leu Tyr Glu His Phe Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile 
385                 390                 395                 400 


His Leu Lys Gly Leu Xaa Gly Xaa Ala Gly Lys Ile Ser Ser Ile Ser 
                405                 410                 415     


Gln Pro Gly Asn Asp Phe Ser Xaa Lys Asp Gly Asp Asn Asp Lys Cys 
            420                 425                 430         


Ile Cys Lys Cys Ser Gln Met Leu Xaa Gly Gly Arg Asp Asp Phe Leu 
        435                 440                 445             


Ser Ser Tyr Leu Tyr Trp Gln Gly Met Ile Ser 
    450                 455                 


<210> 2278
<211> 495
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(487)
<223> Selenocysteine

<400> 2278
Met Trp Gln Ile Val Phe Phe Xaa Leu Ser Cys Asp Leu Val Leu Ala 
1               5                   10                  15      


Ala Ala Tyr Asn Asn Phe Arg Lys Ser Met Asp Ser Ile Gly Lys Lys 
            20                  25                  30          


Gln Tyr Gln Val Gln His Gly Ser Cys Ser Tyr Xaa Phe Leu Leu Pro 
        35                  40                  45              


Glu Met Asp Asn Cys Arg Ser Ser Ser Ser Pro Tyr Val Ser Asn Ala 
    50                  55                  60                  


Val Gln Arg Asp Ala Pro Leu Glu Tyr Asp Asp Ser Val Gln Arg Leu 
65                  70                  75                  80  


Gln Val Leu Glu Asn Ile Met Glu Asn Asn Xaa Gln Trp Leu Met Lys 
                85                  90                  95      


Leu Glu Asn Tyr Ile Gln Asp Asn Met Lys Lys Glu Met Val Glu Ile 
            100                 105                 110         


Gln Gln Asn Ala Val Gln Asn Gln Xaa Ala Val Met Ile Glu Ile Gly 
        115                 120                 125             


Xaa Asn Leu Leu Asn Gln Xaa Ala Glu Gln Xaa Arg Lys Leu Xaa Asp 
    130                 135                 140                 


Val Glu Ala Gln Val Leu Asn Gln Xaa Xaa Arg Leu Glu Leu Gln Leu 
145                 150                 155                 160 


Leu Glu His Ser Leu Ser Xaa Asn Lys Leu Glu Lys Gln Ile Leu Asp 
                165                 170                 175     


Gln Xaa Ser Glu Ile Asn Lys Leu Gln Asp Lys Asn Ser Phe Leu Glu 
            180                 185                 190         


Lys Lys Val Leu Ala Met Glu Asp Lys His Ile Ile Gln Leu Gln Ser 
        195                 200                 205             


Ile Lys Glu Glu Lys Asp Gln Leu Gln Val Leu Val Ser Lys Gln Asn 
    210                 215                 220                 


Ser Ile Ile Glu Glu Leu Glu Lys Lys Ile Val Xaa Ala Xaa Val Asn 
225                 230                 235                 240 


Asn Ser Val Leu Gln Lys Gln Gln His Asp Leu Met Glu Xaa Val Asn 
                245                 250                 255     


Asn Leu Leu Xaa Met Met Ser Xaa Ser Asn Ser Lys Asp Pro Xaa Val 
            260                 265                 270         


Ala Lys Glu Glu Gln Ile Ser Phe Arg Asp Cys Ala Glu Val Phe Lys 
        275                 280                 285             


Ser Gly His Xaa Xaa Asn Gly Ile Tyr Xaa Leu Xaa Phe Pro Asn Ser 
    290                 295                 300                 


Xaa Glu Glu Ile Lys Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly 
305                 310                 315                 320 


Trp Xaa Ile Ile Gln Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg 
                325                 330                 335     


Xaa Trp Lys Glu Tyr Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr 
            340                 345                 350         


Trp Leu Gly Asn Glu Phe Val Ser Gln Leu Xaa Asn Gln Gln Arg Tyr 
        355                 360                 365             


Val Leu Lys Ile His Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser 
    370                 375                 380                 


Leu Tyr Glu His Phe Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile 
385                 390                 395                 400 


His Leu Lys Gly Leu Xaa Gly Xaa Ala Gly Lys Ile Ser Ser Ile Ser 
                405                 410                 415     


Gln Pro Gly Asn Asp Phe Ser Xaa Lys Asp Gly Asp Asn Asp Lys Cys 
            420                 425                 430         


Ile Cys Lys Cys Ser Gln Met Leu Xaa Gly Gly Trp Trp Phe Asp Ala 
        435                 440                 445             


Cys Gly Pro Ser Asn Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn 
    450                 455                 460                 


Xaa Asn Lys Phe Asn Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly 
465                 470                 475                 480 


Tyr Ser Leu Lys Ala Xaa Xaa Met Met Ile Arg Pro Ala Asp Phe 
                485                 490                 495 


<210> 2279
<211> 496
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(488)
<223> Selenocysteine

<400> 2279
Met Trp Gln Ile Val Phe Phe Xaa Leu Ser Cys Asp Leu Val Leu Ala 
1               5                   10                  15      


Ala Ala Tyr Asn Asn Phe Arg Lys Ser Met Asp Ser Ile Gly Lys Lys 
            20                  25                  30          


Gln Tyr Gln Val Gln His Gly Ser Cys Ser Tyr Xaa Phe Leu Leu Pro 
        35                  40                  45              


Glu Met Asp Asn Cys Arg Ser Ser Ser Ser Pro Tyr Val Ser Asn Ala 
    50                  55                  60                  


Val Gln Arg Asp Ala Pro Leu Glu Tyr Asp Asp Ser Val Gln Arg Leu 
65                  70                  75                  80  


Gln Val Leu Glu Asn Ile Met Glu Asn Asn Xaa Gln Trp Leu Met Lys 
                85                  90                  95      


Leu Glu Asn Tyr Ile Gln Asp Asn Met Lys Lys Glu Met Val Glu Ile 
            100                 105                 110         


Gln Gln Asn Ala Val Gln Asn Gln Xaa Ala Val Met Ile Glu Ile Gly 
        115                 120                 125             


Xaa Asn Leu Leu Asn Gln Xaa Ala Glu Gln Xaa Arg Lys Leu Xaa Asp 
    130                 135                 140                 


Val Glu Ala Gln Val Leu Asn Gln Xaa Xaa Arg Leu Glu Leu Gln Leu 
145                 150                 155                 160 


Leu Glu His Ser Leu Ser Xaa Asn Lys Leu Glu Lys Gln Ile Leu Asp 
                165                 170                 175     


Gln Xaa Ser Glu Ile Asn Lys Leu Gln Asp Lys Asn Ser Phe Leu Glu 
            180                 185                 190         


Lys Lys Val Leu Ala Met Glu Asp Lys His Ile Ile Gln Leu Gln Ser 
        195                 200                 205             


Ile Lys Glu Glu Lys Asp Gln Leu Gln Val Leu Val Ser Lys Gln Asn 
    210                 215                 220                 


Ser Ile Ile Glu Glu Leu Glu Lys Lys Ile Val Xaa Ala Xaa Val Asn 
225                 230                 235                 240 


Asn Ser Val Leu Gln Lys Gln Gln His Asp Leu Met Glu Xaa Val Asn 
                245                 250                 255     


Asn Leu Leu Xaa Met Met Ser Xaa Ser Asn Ser Ala Lys Asp Pro Xaa 
            260                 265                 270         


Val Ala Lys Glu Glu Gln Ile Ser Phe Arg Asp Cys Ala Glu Val Phe 
        275                 280                 285             


Lys Ser Gly His Xaa Xaa Asn Gly Ile Tyr Xaa Leu Xaa Phe Pro Asn 
    290                 295                 300                 


Ser Xaa Glu Glu Ile Lys Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly 
305                 310                 315                 320 


Gly Trp Xaa Ile Ile Gln Arg Arg Glu Asp Gly Ser Val Asp Phe Gln 
                325                 330                 335     


Arg Xaa Trp Lys Glu Tyr Lys Val Gly Phe Gly Asn Pro Ser Gly Glu 
            340                 345                 350         


Tyr Trp Leu Gly Asn Glu Phe Val Ser Gln Leu Xaa Asn Gln Gln Arg 
        355                 360                 365             


Tyr Val Leu Lys Ile His Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr 
    370                 375                 380                 


Ser Leu Tyr Glu His Phe Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg 
385                 390                 395                 400 


Ile His Leu Lys Gly Leu Xaa Gly Xaa Ala Gly Lys Ile Ser Ser Ile 
                405                 410                 415     


Ser Gln Pro Gly Asn Asp Phe Ser Xaa Lys Asp Gly Asp Asn Asp Lys 
            420                 425                 430         


Cys Ile Cys Lys Cys Ser Gln Met Leu Xaa Gly Gly Trp Trp Phe Asp 
        435                 440                 445             


Ala Cys Gly Pro Ser Asn Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln 
    450                 455                 460                 


Asn Xaa Asn Lys Phe Asn Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser 
465                 470                 475                 480 


Gly Tyr Ser Leu Lys Ala Xaa Xaa Met Met Ile Arg Pro Ala Asp Phe 
                485                 490                 495     


<210> 2280
<211> 444
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(436)
<223> Selenocysteine

<400> 2280
Met Trp Gln Ile Val Phe Phe Xaa Leu Ser Cys Asp Leu Val Leu Ala 
1               5                   10                  15      


Ala Ala Tyr Asn Asn Phe Arg Lys Ser Met Asp Ser Ile Gly Lys Lys 
            20                  25                  30          


Gln Tyr Gln Val Gln His Gly Ser Cys Ser Tyr Xaa Phe Leu Leu Pro 
        35                  40                  45              


Glu Met Asp Asn Cys Arg Ser Ser Ser Ser Pro Tyr Val Ser Asn Ala 
    50                  55                  60                  


Val Gln Arg Asp Ala Pro Leu Glu Tyr Asp Asp Ser Val Gln Arg Leu 
65                  70                  75                  80  


Gln Val Leu Glu Asn Ile Met Glu Asn Asn Xaa Gln Trp Leu Met Lys 
                85                  90                  95      


Val Leu Asn Gln Xaa Xaa Arg Leu Glu Leu Gln Leu Leu Glu His Ser 
            100                 105                 110         


Leu Ser Xaa Asn Lys Leu Glu Lys Gln Ile Leu Asp Gln Xaa Ser Glu 
        115                 120                 125             


Ile Asn Lys Leu Gln Asp Lys Asn Ser Phe Leu Glu Lys Lys Val Leu 
    130                 135                 140                 


Ala Met Glu Asp Lys His Ile Ile Gln Leu Gln Ser Ile Lys Glu Glu 
145                 150                 155                 160 


Lys Asp Gln Leu Gln Val Leu Val Ser Lys Gln Asn Ser Ile Ile Glu 
                165                 170                 175     


Glu Leu Glu Lys Lys Ile Val Xaa Ala Xaa Val Asn Asn Ser Val Leu 
            180                 185                 190         


Gln Lys Gln Gln His Asp Leu Met Glu Xaa Val Asn Asn Leu Leu Xaa 
        195                 200                 205             


Met Met Ser Xaa Ser Asn Ser Ala Lys Asp Pro Xaa Val Ala Lys Glu 
    210                 215                 220                 


Glu Gln Ile Ser Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His 
225                 230                 235                 240 


Xaa Xaa Asn Gly Ile Tyr Xaa Leu Xaa Phe Pro Asn Ser Xaa Glu Glu 
                245                 250                 255     


Ile Lys Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Xaa Ile 
            260                 265                 270         


Ile Gln Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Xaa Trp Lys 
        275                 280                 285             


Glu Tyr Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly 
    290                 295                 300                 


Asn Glu Phe Val Ser Gln Leu Xaa Asn Gln Gln Arg Tyr Val Leu Lys 
305                 310                 315                 320 


Ile His Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu 
                325                 330                 335     


His Phe Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys 
            340                 345                 350         


Gly Leu Xaa Gly Xaa Ala Gly Lys Ile Ser Ser Ile Ser Gln Pro Gly 
        355                 360                 365             


Asn Asp Phe Ser Xaa Lys Asp Gly Asp Asn Asp Lys Cys Ile Cys Lys 
    370                 375                 380                 


Cys Ser Gln Met Leu Xaa Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro 
385                 390                 395                 400 


Ser Asn Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Xaa Asn Lys 
                405                 410                 415     


Phe Asn Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu 
            420                 425                 430         


Lys Ala Xaa Xaa Met Met Ile Arg Pro Ala Asp Phe 
        435                 440                 


<210> 2281
<211> 503
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<400> 2281
Met Leu Ser Gln Leu Ala Met Leu Gln Gly Ser Leu Leu Leu Val Val 
1               5                   10                  15      


Ala Xaa Met Ser Val Ala Gln Gln Xaa Arg Gln Glu Ala Asp Arg Gly 
            20                  25                  30          


Cys Glu Xaa Leu Val Val Gln His Gly His Cys Ser Tyr Xaa Phe Leu 
        35                  40                  45              


Leu Pro Lys Ser Glu Pro Cys Pro Pro Gly Pro Glu Val Ser Arg Asp 
    50                  55                  60                  


Ser Asn Xaa Leu Gln Arg Glu Ser Leu Ala Asn Pro Leu His Leu Gly 
65                  70                  75                  80  


Lys Leu Pro Xaa Gln Gln Val Lys Gln Leu Glu Gln Ala Leu Gln Asn 
                85                  90                  95      


Asn Xaa Gln Trp Leu Lys Lys Leu Glu Arg Ala Ile Lys Xaa Ile Leu 
            100                 105                 110         


Arg Ser Lys Leu Glu Gln Val Gln Gln Gln Met Ala Gln Asn Gln Xaa 
        115                 120                 125             


Ala Pro Met Leu Glu Leu Gly Xaa Ser Leu Leu Asn Gln Xaa Xaa Ala 
    130                 135                 140                 


Gln Ile Arg Lys Leu Xaa Asp Met Glu Ala Gln Leu Leu Asn Gln Xaa 
145                 150                 155                 160 


Ser Arg Met Asp Ala Gln Met Pro Glu Xaa Phe Leu Ser Xaa Asn Lys 
                165                 170                 175     


Leu Glu Asn Gln Leu Leu Leu Gln Arg Gln Lys Leu Gln Gln Leu Gln 
            180                 185                 190         


Gly Gln Asn Ser Ala Leu Glu Lys Arg Leu Gln Ala Leu Glu Xaa Lys 
        195                 200                 205             


Gln Gln Glu Glu Leu Ala Ser Ile Leu Ser Lys Lys Ala Lys Leu Leu 
    210                 215                 220                 


Asn Xaa Leu Ser Arg Gln Ser Ala Ala Leu Xaa Asn Ile Glu Arg Gly 
225                 230                 235                 240 


Leu Arg Gly Val Arg His Asn Ser Ser Leu Leu Gln Asp Gln Gln His 
                245                 250                 255     


Ser Leu Arg Gln Leu Leu Val Leu Leu Arg His Leu Val Gln Glu Arg 
            260                 265                 270         


Ala Asn Ala Ser Ala Pro Ala Phe Ile Met Ala Gly Glu Gln Val Phe 
        275                 280                 285             


Gln Asp Cys Ala Glu Ile Gln Arg Ser Gly Ala Ser Ala Ser Gly Val 
    290                 295                 300                 


Tyr Xaa Ile Gln Val Ser Asn Ala Xaa Lys Pro Arg Lys Val Phe Cys 
305                 310                 315                 320 


Asp Leu Gln Ser Ser Gly Gly Arg Trp Xaa Leu Ile Gln Arg Arg Glu 
                325                 330                 335     


Asn Gly Xaa Val Asn Phe Gln Arg Asn Trp Lys Asp Tyr Lys Gln Gly 
            340                 345                 350         


Phe Gly Asp Pro Ala Gly Glu His Trp Leu Gly Asn Glu Val Val His 
        355                 360                 365             


Gln Leu Xaa Arg Arg Ala Ala Tyr Ser Leu Arg Val Glu Leu Gln Asp 
    370                 375                 380                 


Trp Glu Gly His Glu Ala Tyr Ala Gln Tyr Glu His Phe His Leu Gly 
385                 390                 395                 400 


Ser Glu Asn Gln Leu Tyr Arg Leu Ser Val Val Gly Tyr Ser Gly Ser 
                405                 410                 415     


Ala Gly Arg Gln Ser Ser Leu Val Leu Gln Asn Xaa Ser Phe Ser Xaa 
            420                 425                 430         


Leu Asp Ser Asp Asn Asp His Cys Leu Cys Lys Cys Ala Gln Val Met 
        435                 440                 445             


Ser Gly Gly Trp Trp Phe Asp Ala Cys Gly Leu Ser Asn Leu Asn Gly 
    450                 455                 460                 


Val Tyr Tyr His Ala Pro Asp Asn Lys Tyr Lys Met Asp Gly Ile Arg 
465                 470                 475                 480 


Trp His Tyr Phe Lys Gly Pro Ser Tyr Ser Leu Arg Ala Ser Arg Met 
                485                 490                 495     


Met Ile Arg Pro Leu Asp Ile 
            500             


<210> 2282
<211> 114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 2282
Met Lys Xaa Phe Xaa Trp Xaa Leu Gly Val Leu Phe Phe Leu Leu Val 
1               5                   10                  15      


Asp Xaa Gly His Cys Arg Gly Gly Gln Phe Lys Ile Lys Lys Ile Asn 
            20                  25                  30          


Gln Arg Arg Tyr Pro Arg Ala Xaa Asp Gly Lys Glu Glu Ala Lys Lys 
        35                  40                  45              


Cys Ala Tyr Xaa Phe Leu Val Pro Glu Gln Arg Ile Xaa Gly Pro Ile 
    50                  55                  60                  


Cys Val Asn Xaa Lys Gly Gln Asp Ala Ser Xaa Ile Lys Asp Met Ile 
65                  70                  75                  80  


Xaa Arg Met Asp Leu Glu Asn Leu Lys Asp Val Leu Ser Arg Gln Lys 
                85                  90                  95      


Arg Glu Ile Asp Val Leu Gln Leu Val Val Asp Val Asp Gly Asn Ile 
            100                 105                 110         


Val Asn 
        


<210> 2283
<211> 491
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(420)
<223> Selenocysteine

<400> 2283
Met Lys Xaa Phe Xaa Trp Xaa Leu Gly Val Leu Phe Phe Leu Leu Val 
1               5                   10                  15      


Asp Xaa Gly His Cys Arg Gly Gly Gln Phe Lys Ile Lys Lys Ile Asn 
            20                  25                  30          


Gln Arg Arg Tyr Pro Arg Ala Xaa Asp Gly Lys Glu Glu Ala Lys Lys 
        35                  40                  45              


Cys Ala Tyr Xaa Phe Leu Val Pro Glu Gln Arg Ile Xaa Gly Pro Ile 
    50                  55                  60                  


Cys Val Asn Xaa Lys Gly Gln Asp Ala Ser Xaa Ile Lys Asp Met Ile 
65                  70                  75                  80  


Xaa Arg Met Asp Leu Glu Asn Leu Lys Asp Val Leu Ser Arg Gln Lys 
                85                  90                  95      


Arg Glu Ile Asp Val Leu Gln Leu Val Val Asp Val Asp Gly Asn Ile 
            100                 105                 110         


Val Asn Glu Val Lys Leu Leu Arg Lys Glu Ser Arg Asn Met Asn Ser 
        115                 120                 125             


Arg Val Xaa Gln Leu Tyr Met Gln Leu Leu His Glu Ile Ile Arg Lys 
    130                 135                 140                 


Arg Asp Asn Ser Leu Glu Leu Ser Gln Leu Glu Asn Lys Ile Leu Asn 
145                 150                 155                 160 


Val Xaa Xaa Glu Met Leu Lys Met Ala Xaa Arg Tyr Arg Glu Leu Glu 
                165                 170                 175     


Val Lys Tyr Ala Ser Leu Xaa Asp Leu Val Asn Asn Gln Ser Val Met 
            180                 185                 190         


Ile Xaa Leu Leu Glu Glu Gln Cys Leu Arg Ile Phe Ser Arg Gln Asp 
        195                 200                 205             


Xaa His Val Ser Pro Pro Leu Val Gln Val Val Pro Gln His Ile Pro 
    210                 215                 220                 


Asn Ser Gln Gln Tyr Xaa Pro Gly Leu Leu Gly Gly Asn Glu Ile Gln 
225                 230                 235                 240 


Arg Asp Pro Gly Tyr Pro Arg Asp Leu Met Pro Pro Pro Asp Leu Ala 
                245                 250                 255     


Xaa Ser Pro Xaa Lys Ser Pro Phe Lys Ile Pro Pro Val Xaa Phe Ile 
            260                 265                 270         


Asn Glu Gly Pro Phe Lys Asp Cys Gln Gln Ala Lys Glu Ala Gly His 
        275                 280                 285             


Ser Val Ser Gly Ile Tyr Met Ile Lys Pro Glu Asn Ser Asn Gly Pro 
    290                 295                 300                 


Met Gln Leu Trp Cys Glu Asn Ser Leu Asp Pro Gly Gly Trp Xaa Val 
305                 310                 315                 320 


Ile Gln Lys Arg Xaa Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu 
                325                 330                 335     


Asn Tyr Lys Lys Gly Phe Gly Asn Ile Asp Gly Glu Tyr Trp Leu Gly 
            340                 345                 350         


Leu Glu Asn Ile Tyr Met Leu Ser Asn Gln Asp Asn Tyr Lys Leu Leu 
        355                 360                 365             


Ile Glu Leu Glu Asp Trp Ser Asp Lys Lys Val Tyr Ala Glu Tyr Ser 
    370                 375                 380                 


Ser Phe Arg Leu Glu Pro Glu Ser Glu Phe Tyr Arg Leu Arg Leu Gly 
385                 390                 395                 400 


Xaa Tyr Gln Gly Asn Ala Gly Asp Ser Met Met Trp His Asn Gly Lys 
                405                 410                 415     


Gln Phe Xaa Xaa Leu Asp Arg Asp Lys Asp Met Tyr Ala Gly Asn Cys 
            420                 425                 430         


Ala His Phe His Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser 
        435                 440                 445             


Asn Leu Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Lys His 
    450                 455                 460                 


Gln Asp Gly Ile Phe Trp Ala Glu Tyr Arg Gly Gly Ser Tyr Ser Leu 
465                 470                 475                 480 


Arg Ala Val Gln Met Met Ile Lys Pro Ile Asp 
                485                 490     


<210> 2284
<211> 460
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<400> 2284
Met Phe Xaa Ile Lys Leu Leu Leu Phe Ile Val Pro Leu Val Ile Ser 
1               5                   10                  15      


Ser Arg Ile Asp Gln Asp Asn Ser Ser Phe Asp Ser Leu Ser Pro Glu 
            20                  25                  30          


Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn 
        35                  40                  45              


Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Xaa 
    50                  55                  60                  


Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile Phe Asp Gln 
65                  70                  75                  80  


Ser Phe Tyr Asp Leu Ser Leu Gln Xaa Ser Glu Ile Lys Glu Glu Glu 
                85                  90                  95      


Lys Glu Leu Arg Arg Xaa Xaa Tyr Lys Leu Gln Val Lys Asn Glu Glu 
            100                 105                 110         


Val Lys Asn Met Ser Leu Glu Leu Asn Ser Lys Leu Glu Ser Leu Leu 
        115                 120                 125             


Glu Glu Lys Ile Leu Leu Gln Gln Lys Val Lys Tyr Leu Glu Glu Gln 
    130                 135                 140                 


Leu Xaa Asn Leu Ile Gln Asn Gln Pro Glu Xaa Pro Glu His Pro Glu 
145                 150                 155                 160 


Val Xaa Ser Leu Lys Xaa Phe Val Glu Lys Gln Asp Asn Ser Ile Lys 
                165                 170                 175     


Asp Leu Leu Gln Xaa Val Glu Asp Gln Tyr Lys Gln Leu Asn Gln Gln 
            180                 185                 190         


His Ser Gln Ile Lys Glu Ile Glu Asn Gln Leu Arg Arg Xaa Ser Ile 
        195                 200                 205             


Gln Glu Pro Xaa Glu Ile Ser Leu Ser Ser Lys Pro Arg Ala Pro Arg 
    210                 215                 220                 


Xaa Xaa Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp 
225                 230                 235                 240 


Gly Ile Pro Ala Glu Cys Xaa Xaa Ile Tyr Asn Arg Gly Glu His Xaa 
                245                 250                 255     


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
            260                 265                 270         


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Xaa Leu Ile Gln His Arg 
        275                 280                 285             


Ile Asp Gly Ser Gln Asn Phe Asn Glu Xaa Trp Glu Asn Tyr Lys Tyr 
    290                 295                 300                 


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
305                 310                 315                 320 


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
                325                 330                 335     


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
            340                 345                 350         


Asn His Glu Xaa Asn Tyr Xaa Leu His Leu Val Ala Ile Xaa Gly Asn 
        355                 360                 365             


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Xaa Trp 
    370                 375                 380                 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
385                 390                 395                 400 


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
                405                 410                 415     


Tyr Asn Lys Pro Arg Ala Lys Ser Lys Pro Glu Arg Arg Arg Gly Leu 
            420                 425                 430         


Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Xaa Lys 
        435                 440                 445             


Met Leu Ile His Pro Xaa Asp Ser Glu Ser Phe Glu 
    450                 455                 460 


<210> 2285
<211> 379
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<400> 2285
Met Gln Ser Phe Leu Xaa Leu Leu Lys Glu His Glu Asp Xaa Cys Ala 
1               5                   10                  15      


Pro Pro Ala Glu Leu Val Xaa Leu Ala Gly Arg Leu Cys Arg Asp Phe 
            20                  25                  30          


Gln Asp Asp Leu Ala Gln Leu Gln Pro Leu Val Xaa Ala Ile Leu Asp 
        35                  40                  45              


Ser Gln Leu Arg Leu His Leu Leu Asp Asn Ala Asp Val Ala Leu Ala 
    50                  55                  60                  


Cys Ala Arg Val Leu Asp Gln Gln Glu Gln Gln Gln Ala Ala Cys Arg 
65                  70                  75                  80  


Leu Leu Glu Gly Cys Gln Val Pro Gly Gly Ser Gln Glu Leu Val Gln 
                85                  90                  95      


Leu Trp Asn Asp Ile His Tyr Arg Leu Val Met Arg Arg Leu Gly Val 
            100                 105                 110         


Ala Ala Leu Xaa Pro Val Gln Lys Phe Arg Cys Arg Lys Arg Asn Pro 
        115                 120                 125             


Pro Pro Pro Ser Leu Cys Pro Glu Gly Leu Lys Ser Arg Asn Phe Pro 
    130                 135                 140                 


Arg Glu Val Arg Glu Lys Leu His Asn Phe Ala Val Gly Val Asn Xaa 
145                 150                 155                 160 


Asn Pro Ser Lys Ala Glu Arg Glu Asn Leu Ala Leu Glu Xaa Ser Leu 
                165                 170                 175     


Xaa Pro Glu Gln Val Tyr Asn Trp Phe Ala Asn Tyr Arg Arg Arg Gln 
            180                 185                 190         


Arg Ala Leu Pro Gln His Met Lys Pro Ala Gln Gln Ala Xaa Ala Glu 
        195                 200                 205             


Asp Pro Gly Ala Arg Glu Arg Gly Pro Asp Leu Leu Gln Pro Ser Gly 
    210                 215                 220                 


Asn Pro Arg Val Asp Ser Gly Phe Val Asp Arg Pro Gln Trp Ser Glu 
225                 230                 235                 240 


Glu Arg Glu Glu Lys Gly Pro Pro Gln Ser Pro Gln Xaa Xaa Gln Gly 
                245                 250                 255     


Pro Trp Glu Pro Leu Ala Leu Ala Pro Asp Phe Pro Ala Asp Glu Xaa 
            260                 265                 270         


Val Ser Lys Pro Leu Asp Val Ser Gly His Pro Gln Ser Val Gln Leu 
        275                 280                 285             


Glu Glu Gly Leu Gly Xaa Ser Ser Gly Arg Xaa Glu Leu Arg Val Gly 
    290                 295                 300                 


Ser Phe Leu Val Xaa Gln Pro Pro Leu Gln Ala Pro Glu Phe Ile Leu 
305                 310                 315                 320 


Xaa Gln Ser Pro Pro Glu Leu Ala Pro Ala Pro Ser Ala Phe Pro Gly 
                325                 330                 335     


Pro Val Ser Ala Met Glu Leu Ser Gln Ala Leu Pro Ser Ser Gln Val 
            340                 345                 350         


Gln Cys Ser Asp Ser Gln Ala Ser Gly Asp Ala Phe Trp Gly Ala Arg 
        355                 360                 365             


Met Leu Leu Glu Phe Ser Gly Ser Ser Leu Gly 
    370                 375                 


<210> 2286
<211> 1897
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (983)..(983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1197)..(1197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1208)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1221)..(1221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1245)..(1246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1260)..(1260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1268)..(1268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1393)..(1393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1403)..(1403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1419)..(1419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1421)..(1421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1510)..(1510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1541)..(1541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1600)..(1600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1615)..(1615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1620)..(1620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1637)..(1637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1666)..(1666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1672)..(1672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1701)..(1701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1725)..(1725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1729)..(1729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1734)..(1734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1767)..(1767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1776)..(1776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1778)..(1778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1780)..(1780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1802)..(1802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1804)..(1804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1833)..(1833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1835)..(1835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1852)..(1852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1857)..(1857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1865)..(1865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1892)..(1892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1894)..(1894)
<223> Selenocysteine

<400> 2286
Met Ala Gln Ala Ala Lys Gln Leu Lys Lys Ile Lys Asp Ile Glu Ala 
1               5                   10                  15      


Gln Ala Leu Gln Glu Gln Lys Glu Lys Glu Glu Ser Asn Arg Lys Arg 
            20                  25                  30          


Arg Asn Arg Ser Arg Asp Arg Lys Lys Lys Ala Asp Ala Ala Xaa Ser 
        35                  40                  45              


Phe Leu Arg Ala Ala Arg Ser Gly Asn Leu Asp Lys Ala Leu Asp His 
    50                  55                  60                  


Leu Arg Asn Gly Val Asp Ile Asn Xaa Cys Asn Gln Asn Gly Leu Asn 
65                  70                  75                  80  


Gly Leu His Leu Ala Ser Lys Glu Gly His Val Lys Met Val Val Glu 
                85                  90                  95      


Leu Leu His Lys Glu Ile Ile Leu Glu Xaa Xaa Xaa Lys Lys Gly Asn 
            100                 105                 110         


Xaa Ala Leu His Ile Ala Ala Leu Ala Gly Gln Asp Glu Val Val Arg 
        115                 120                 125             


Glu Leu Val Asn Tyr Gly Ala Asn Val Asn Ala Gln Ser Gln Lys Gly 
    130                 135                 140                 


Phe Xaa Pro Leu Tyr Met Ala Ala Gln Glu Asn His Leu Glu Val Val 
145                 150                 155                 160 


Lys Phe Leu Leu Glu Asn Gly Ala Asn Gln Asn Val Ala Xaa Glu Asp 
                165                 170                 175     


Gly Phe Xaa Pro Leu Ala Val Ala Leu Gln Gln Gly His Glu Asn Val 
            180                 185                 190         


Val Ala His Leu Ile Asn Tyr Gly Xaa Lys Gly Lys Val Arg Leu Pro 
        195                 200                 205             


Ala Leu His Ile Ala Ala Arg Asn Asp Asp Xaa Arg Xaa Ala Ala Val 
    210                 215                 220                 


Leu Leu Gln Asn Asp Pro Asn Pro Asp Val Leu Ser Lys Xaa Gly Phe 
225                 230                 235                 240 


Xaa Pro Leu His Ile Ala Ala His Tyr Glu Asn Leu Asn Val Ala Gln 
                245                 250                 255     


Leu Leu Leu Asn Arg Gly Ala Ser Val Asn Phe Xaa Pro Gln Asn Gly 
            260                 265                 270         


Ile Xaa Pro Leu His Ile Ala Ser Arg Arg Gly Asn Val Ile Met Val 
        275                 280                 285             


Arg Leu Leu Leu Asp Arg Gly Ala Gln Ile Glu Xaa Lys Xaa Lys Asp 
    290                 295                 300                 


Glu Leu Xaa Pro Leu His Cys Ala Ala Arg Asn Gly His Val Arg Ile 
305                 310                 315                 320 


Ser Glu Ile Leu Leu Asp His Gly Ala Pro Ile Gln Ala Lys Xaa Lys 
                325                 330                 335     


Asn Gly Leu Ser Pro Ile His Met Ala Ala Gln Gly Asp His Leu Asp 
            340                 345                 350         


Cys Val Arg Leu Leu Leu Gln Tyr Asp Ala Glu Ile Asp Asp Ile Xaa 
        355                 360                 365             


Leu Asp His Leu Xaa Pro Leu His Val Ala Ala His Cys Gly His His 
    370                 375                 380                 


Arg Val Ala Lys Val Leu Leu Asp Lys Gly Ala Lys Pro Asn Ser Arg 
385                 390                 395                 400 


Ala Leu Asn Gly Phe Xaa Pro Leu His Ile Ala Cys Lys Lys Asn His 
                405                 410                 415     


Val Arg Val Met Glu Leu Leu Leu Lys Xaa Gly Ala Ser Ile Asp Ala 
            420                 425                 430         


Val Xaa Glu Ser Gly Leu Xaa Pro Leu His Val Ala Ser Phe Met Gly 
        435                 440                 445             


His Leu Pro Ile Val Lys Asn Leu Leu Gln Arg Gly Ala Ser Pro Asn 
    450                 455                 460                 


Val Ser Asn Val Lys Val Glu Xaa Pro Leu His Met Ala Ala Arg Ala 
465                 470                 475                 480 


Gly His Xaa Glu Val Ala Lys Tyr Leu Leu Gln Asn Lys Ala Lys Val 
                485                 490                 495     


Asn Ala Lys Ala Lys Asp Asp Gln Xaa Pro Leu His Cys Ala Ala Arg 
            500                 505                 510         


Ile Gly His Xaa Asn Met Val Lys Leu Leu Leu Glu Asn Asn Ala Asn 
        515                 520                 525             


Pro Asn Leu Ala Xaa Xaa Ala Gly His Xaa Pro Leu His Ile Ala Ala 
    530                 535                 540                 


Arg Glu Gly His Val Glu Xaa Val Leu Ala Leu Leu Glu Lys Glu Ala 
545                 550                 555                 560 


Ser Gln Ala Cys Met Xaa Lys Lys Gly Phe Xaa Pro Leu His Val Ala 
                565                 570                 575     


Ala Lys Tyr Gly Lys Val Arg Val Ala Glu Leu Leu Leu Glu Arg Asp 
            580                 585                 590         


Ala His Pro Asn Ala Ala Gly Lys Asn Gly Leu Xaa Pro Leu His Val 
        595                 600                 605             


Ala Val His His Asn Asn Leu Asp Ile Val Lys Leu Leu Leu Pro Arg 
    610                 615                 620                 


Gly Gly Ser Pro His Ser Pro Ala Trp Asn Gly Tyr Xaa Pro Leu His 
625                 630                 635                 640 


Ile Ala Ala Lys Gln Asn Gln Val Glu Val Ala Arg Ser Leu Leu Gln 
                645                 650                 655     


Tyr Gly Gly Ser Ala Asn Ala Glu Ser Val Gln Gly Val Xaa Pro Leu 
            660                 665                 670         


His Leu Ala Ala Gln Glu Gly His Ala Glu Met Val Ala Leu Leu Leu 
        675                 680                 685             


Ser Lys Gln Ala Asn Gly Asn Leu Gly Asn Lys Ser Gly Leu Xaa Pro 
    690                 695                 700                 


Leu His Leu Val Ala Gln Glu Gly His Val Pro Val Ala Asp Val Leu 
705                 710                 715                 720 


Ile Lys His Gly Val Met Val Asp Ala Xaa Xaa Arg Met Gly Tyr Xaa 
                725                 730                 735     


Pro Leu His Val Ala Ser His Tyr Gly Asn Ile Lys Leu Val Lys Phe 
            740                 745                 750         


Leu Leu Gln His Gln Ala Asp Val Asn Ala Lys Xaa Lys Leu Gly Tyr 
        755                 760                 765             


Ser Pro Leu His Gln Ala Ala Gln Gln Gly His Xaa Asp Ile Val Xaa 
    770                 775                 780                 


Leu Leu Leu Lys Asn Gly Ala Ser Pro Asn Glu Val Ser Ser Asp Gly 
785                 790                 795                 800 


Xaa Xaa Pro Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile Ser Val Xaa 
                805                 810                 815     


Asp Val Leu Lys Val Val Xaa Asp Glu Xaa Ser Phe Val Leu Val Ser 
            820                 825                 830         


Asp Lys His Arg Met Ser Phe Pro Glu Xaa Val Asp Glu Ile Leu Asp 
        835                 840                 845             


Val Ser Glu Asp Glu Gly Xaa Ala His Ile Xaa Ile Met Gly Glu Glu 
    850                 855                 860                 


Leu Ile Ser Phe Lys Ala Glu Arg Arg Asp Ser Arg Asp Val Asp Glu 
865                 870                 875                 880 


Glu Lys Glu Leu Leu Asp Phe Val Pro Lys Leu Asp Gln Val Val Glu 
                885                 890                 895     


Ser Pro Ala Ile Pro Arg Ile Pro Cys Ala Met Pro Glu Xaa Val Val 
            900                 905                 910         


Ile Arg Ser Glu Glu Gln Glu Gln Ala Ser Lys Glu Tyr Asp Glu Asp 
        915                 920                 925             


Ser Leu Ile Pro Ser Ser Pro Ala Xaa Glu Xaa Ser Asp Asn Ile Ser 
    930                 935                 940                 


Pro Val Ala Ser Pro Val His Xaa Gly Phe Leu Val Ser Phe Met Val 
945                 950                 955                 960 


Asp Ala Arg Gly Gly Ser Met Arg Gly Ser Arg His Asn Gly Leu Arg 
                965                 970                 975     


Val Val Ile Pro Pro Arg Xaa Cys Ala Ala Pro Xaa Arg Ile Xaa Cys 
            980                 985                 990         


Arg Leu Val Lys Pro Gln Lys Leu  Ser Xaa Pro Pro Pro  Leu Ala Glu 
        995                 1000                 1005             


Glu Glu  Gly Leu Ala Ser Arg  Ile Ile Ala Leu Gly  Pro Xaa Gly 
    1010                 1015                 1020             


Ala Gln  Phe Leu Ser Pro Val  Ile Val Glu Ile Pro  His Phe Ala 
    1025                 1030                 1035             


Ser His  Gly Arg Gly Asp Arg  Glu Leu Val Val Leu  Arg Ser Glu 
    1040                 1045                 1050             


Asn Gly  Ser Val Trp Lys Glu  His Arg Ser Arg Tyr  Gly Glu Ser 
    1055                 1060                 1065             


Tyr Leu  Asp Gln Ile Leu Asn  Gly Met Asp Glu Glu  Leu Gly Ser 
    1070                 1075                 1080             


Leu Glu  Glu Leu Glu Lys Lys  Arg Val Cys Arg Ile  Ile Xaa Xaa 
    1085                 1090                 1095             


Asp Phe  Pro Leu Tyr Phe Val  Ile Met Ser Arg Leu  Cys Gln Asp 
    1100                 1105                 1110             


Tyr Asp  Xaa Ile Gly Pro Glu  Gly Gly Ser Leu Lys  Ser Lys Leu 
    1115                 1120                 1125             


Val Pro  Leu Val Gln Ala Xaa  Phe Pro Glu Asn Ala  Val Xaa Lys 
    1130                 1135                 1140             


Arg Val  Lys Leu Ala Leu Gln  Ala Gln Pro Val Pro  Asp Glu Leu 
    1145                 1150                 1155             


Val Xaa  Lys Leu Leu Gly Asn  Gln Ala Xaa Phe Ser  Pro Ile Val 
    1160                 1165                 1170             


Xaa Val  Glu Pro Arg Arg Arg  Lys Phe His Arg Pro  Ile Gly Leu 
    1175                 1180                 1185             


Arg Ile  Pro Leu Pro Pro Ser  Trp Xaa Asp Asn Pro  Arg Asp Ser 
    1190                 1195                 1200             


Gly Glu  Gly Asp Xaa Xaa Ser  Leu Arg Leu Leu Cys  Ser Val Ile 
    1205                 1210                 1215             


Gly Gly  Xaa Asp Gln Ala Gln  Trp Glu Asp Ile Xaa  Gly Xaa Xaa 
    1220                 1225                 1230             


Lys Leu  Val Tyr Ala Asn Glu  Cys Ala Asn Phe Xaa  Xaa Asn Val 
    1235                 1240                 1245             


Ser Ala  Arg Phe Trp Leu Ser  Asp Cys Pro Arg Xaa  Ala Glu Ala 
    1250                 1255                 1260             


Val Asn  Phe Ala Xaa Leu Leu  Tyr Lys Glu Leu Xaa  Ala Val Pro 
    1265                 1270                 1275             


Tyr Met  Ala Lys Phe Val Ile  Phe Ala Lys Met Asn  Asp Pro Arg 
    1280                 1285                 1290             


Glu Gly  Arg Leu Arg Cys Tyr  Cys Met Xaa Asp Asp  Lys Val Asp 
    1295                 1300                 1305             


Lys Xaa  Leu Glu Gln His Glu  Asn Phe Val Glu Val  Ala Arg Ser 
    1310                 1315                 1320             


Arg Asp  Ile Glu Val Leu Glu  Gly Met Ser Leu Phe  Ala Glu Leu 
    1325                 1330                 1335             


Ser Gly  Asn Leu Val Pro Val  Lys Lys Ala Ala Gln  Gln Arg Ser 
    1340                 1345                 1350             


Phe His  Phe Gln Ser Phe Arg  Glu Asn Arg Leu Ala  Met Pro Val 
    1355                 1360                 1365             


Lys Val  Arg Asp Ser Ser Arg  Glu Pro Gly Gly Ser  Leu Ser Phe 
    1370                 1375                 1380             


Leu Arg  Lys Ala Met Lys Tyr  Glu Asp Xaa Gln His  Ile Leu Cys 
    1385                 1390                 1395             


His Leu  Asn Ile Xaa Met Pro  Pro Cys Ala Lys Gly  Ser Gly Ala 
    1400                 1405                 1410             


Glu Asp  Arg Arg Arg Xaa Pro  Xaa Pro Leu Ala Leu  Arg Tyr Ser 
    1415                 1420                 1425             


Ile Leu  Ser Glu Ser Xaa Pro  Gly Ser Leu Ser Gly  Xaa Glu Gln 
    1430                 1435                 1440             


Ala Glu  Met Lys Met Ala Val  Ile Ser Glu His Leu  Gly Leu Ser 
    1445                 1450                 1455             


Trp Ala  Glu Leu Ala Arg Glu  Leu Gln Phe Ser Val  Glu Asp Ile 
    1460                 1465                 1470             


Asn Arg  Ile Arg Val Glu Asn  Pro Asn Ser Leu Leu  Glu Gln Ser 
    1475                 1480                 1485             


Val Ala  Leu Leu Asn Leu Trp  Val Ile Arg Glu Gly  Gln Asn Ala 
    1490                 1495                 1500             


Asn Met  Glu Asn Leu Tyr Xaa  Ala Leu Gln Ser Ile  Asp Arg Gly 
    1505                 1510                 1515             


Glu Ile  Val Asn Met Leu Glu  Gly Ser Gly Arg Gln  Ser Arg Asn 
    1520                 1525                 1530             


Leu Lys  Pro Asp Arg Arg His  Xaa Asp Arg Asp Tyr  Ser Leu Ser 
    1535                 1540                 1545             


Pro Ser  Gln Met Asn Gly Tyr  Ser Ser Leu Gln Asp  Glu Leu Leu 
    1550                 1555                 1560             


Ser Pro  Ala Ser Leu Gly Cys  Ala Leu Ser Ser Pro  Leu Arg Ala 
    1565                 1570                 1575             


Asp Gln  Tyr Trp Asn Glu Val  Ala Val Leu Asp Ala  Ile Pro Leu 
    1580                 1585                 1590             


Ala Ala  Xaa Glu His Asp Xaa  Met Leu Glu Met Ser  Asp Met Gln 
    1595                 1600                 1605             


Val Trp  Ser Ala Gly Leu Xaa  Pro Ser Leu Val Xaa  Ala Glu Asp 
    1610                 1615                 1620             


Ser Ser  Leu Glu Cys Ser Lys  Ala Glu Asp Ser Asp  Ala Xaa Gly 
    1625                 1630                 1635             


His Glu  Trp Lys Leu Glu Gly  Ala Leu Ser Glu Glu  Pro Arg Gly 
    1640                 1645                 1650             


Pro Glu  Leu Gly Ser Leu Glu  Leu Val Glu Asp Asp  Xaa Val Asp 
    1655                 1660                 1665             


Ser Asp  Ala Xaa Asn Gly Leu  Ile Asp Leu Leu Glu  Gln Glu Glu 
    1670                 1675                 1680             


Gly Gln  Arg Ser Glu Glu Lys  Leu Pro Gly Ser Lys  Arg Gln Asp 
    1685                 1690                 1695             


Asp Ala  Xaa Gly Ala Gly Gln  Asp Ser Glu Asn Glu  Val Ser Leu 
    1700                 1705                 1710             


Val Ser  Gly His Gln Arg Gly  Gln Ala Arg Ile Xaa  His Ser Pro 
    1715                 1720                 1725             


Xaa Val  Ser Gln Val Xaa Glu  Arg Ser Gln Asp Arg  Leu Gln Asp 
    1730                 1735                 1740             


Trp Asp  Ala Asp Gly Ser Ile  Val Ser Tyr Leu Gln  Asp Ala Ala 
    1745                 1750                 1755             


Gln Gly  Ser Trp Gln Glu Glu  Val Xaa Gln Gly Pro  His Ser Phe 
    1760                 1765                 1770             


Gln Gly  Xaa Ser Xaa Met Xaa  Glu Gly Leu Glu Pro  Gly Gly Ser 
    1775                 1780                 1785             


Gln Glu  Tyr Glu Lys Val Leu  Val Ser Val Ser Glu  His Xaa Trp 
    1790                 1795                 1800             


Xaa Glu  Gln Pro Glu Ala Glu  Ser Ser Gln Ala Asp  Arg Asp Arg 
    1805                 1810                 1815             


Arg Gln  Gln Gly Gln Glu Glu  Gln Val Gln Glu Ala  Lys Asn Xaa 
    1820                 1825                 1830             


Phe Xaa  Gln Val Val Gln Gly  Asn Glu Phe Gln Asn  Ile Pro Gly 
    1835                 1840                 1845             


Glu Gln  Val Xaa Glu Glu Gln  Phe Xaa Asp Glu Gln  Gly Asn Ile 
    1850                 1855                 1860             


Val Xaa  Lys Lys Ile Ile Arg  Lys Val Val Arg Gln  Ile Asp Leu 
    1865                 1870                 1875             


Ser Ser  Ala Asp Ala Ala Gln  Glu His Glu Glu Asp  His Xaa Ser 
    1880                 1885                 1890             


Xaa Pro  Asn Pro 
    1895         


<210> 2287
<211> 1880
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1189)..(1189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1191)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1234)..(1234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1262)..(1262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1378)..(1378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1380)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1393)..(1393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1400)..(1400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1469)..(1469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1500)..(1500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1559)..(1559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1579)..(1579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1625)..(1625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1631)..(1631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1660)..(1660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1684)..(1684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1688)..(1688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1693)..(1693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1726)..(1726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1735)..(1735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1737)..(1737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1739)..(1739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1763)..(1763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1792)..(1792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1794)..(1794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1811)..(1811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1816)..(1816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1824)..(1824)
<223> Selenocysteine

<400> 2287
Met Pro Tyr Ser Val Gly Phe Arg Glu Ala Asp Ala Ala Xaa Ser Phe 
1               5                   10                  15      


Leu Arg Ala Ala Arg Ser Gly Asn Leu Asp Lys Ala Leu Asp His Leu 
            20                  25                  30          


Arg Asn Gly Val Asp Ile Asn Xaa Cys Asn Gln Asn Gly Leu Asn Gly 
        35                  40                  45              


Leu His Leu Ala Ser Lys Glu Gly His Val Lys Met Val Val Glu Leu 
    50                  55                  60                  


Leu His Lys Glu Ile Ile Leu Glu Xaa Xaa Xaa Lys Lys Gly Asn Xaa 
65                  70                  75                  80  


Ala Leu His Ile Ala Ala Leu Ala Gly Gln Asp Glu Val Val Arg Glu 
                85                  90                  95      


Leu Val Asn Tyr Gly Ala Asn Val Asn Ala Gln Ser Gln Lys Gly Phe 
            100                 105                 110         


Xaa Pro Leu Tyr Met Ala Ala Gln Glu Asn His Leu Glu Val Val Lys 
        115                 120                 125             


Phe Leu Leu Glu Asn Gly Ala Asn Gln Asn Val Ala Xaa Glu Asp Gly 
    130                 135                 140                 


Phe Xaa Pro Leu Ala Val Ala Leu Gln Gln Gly His Glu Asn Val Val 
145                 150                 155                 160 


Ala His Leu Ile Asn Tyr Gly Xaa Lys Gly Lys Val Arg Leu Pro Ala 
                165                 170                 175     


Leu His Ile Ala Ala Arg Asn Asp Asp Xaa Arg Xaa Ala Ala Val Leu 
            180                 185                 190         


Leu Gln Asn Asp Pro Asn Pro Asp Val Leu Ser Lys Xaa Gly Phe Xaa 
        195                 200                 205             


Pro Leu His Ile Ala Ala His Tyr Glu Asn Leu Asn Val Ala Gln Leu 
    210                 215                 220                 


Leu Leu Asn Arg Gly Ala Ser Val Asn Phe Xaa Pro Gln Asn Gly Ile 
225                 230                 235                 240 


Xaa Pro Leu His Ile Ala Ser Arg Arg Gly Asn Val Ile Met Val Arg 
                245                 250                 255     


Leu Leu Leu Asp Arg Gly Ala Gln Ile Glu Xaa Lys Xaa Lys Asp Glu 
            260                 265                 270         


Leu Xaa Pro Leu His Cys Ala Ala Arg Asn Gly His Val Arg Ile Ser 
        275                 280                 285             


Glu Ile Leu Leu Asp His Gly Ala Pro Ile Gln Ala Lys Xaa Lys Asn 
    290                 295                 300                 


Gly Leu Ser Pro Ile His Met Ala Ala Gln Gly Asp His Leu Asp Cys 
305                 310                 315                 320 


Val Arg Leu Leu Leu Gln Tyr Asp Ala Glu Ile Asp Asp Ile Xaa Leu 
                325                 330                 335     


Asp His Leu Xaa Pro Leu His Val Ala Ala His Cys Gly His His Arg 
            340                 345                 350         


Val Ala Lys Val Leu Leu Asp Lys Gly Ala Lys Pro Asn Ser Arg Ala 
        355                 360                 365             


Leu Asn Gly Phe Xaa Pro Leu His Ile Ala Cys Lys Lys Asn His Val 
    370                 375                 380                 


Arg Val Met Glu Leu Leu Leu Lys Xaa Gly Ala Ser Ile Asp Ala Val 
385                 390                 395                 400 


Xaa Glu Ser Gly Leu Xaa Pro Leu His Val Ala Ser Phe Met Gly His 
                405                 410                 415     


Leu Pro Ile Val Lys Asn Leu Leu Gln Arg Gly Ala Ser Pro Asn Val 
            420                 425                 430         


Ser Asn Val Lys Val Glu Xaa Pro Leu His Met Ala Ala Arg Ala Gly 
        435                 440                 445             


His Xaa Glu Val Ala Lys Tyr Leu Leu Gln Asn Lys Ala Lys Val Asn 
    450                 455                 460                 


Ala Lys Ala Lys Asp Asp Gln Xaa Pro Leu His Cys Ala Ala Arg Ile 
465                 470                 475                 480 


Gly His Xaa Asn Met Val Lys Leu Leu Leu Glu Asn Asn Ala Asn Pro 
                485                 490                 495     


Asn Leu Ala Xaa Xaa Ala Gly His Xaa Pro Leu His Ile Ala Ala Arg 
            500                 505                 510         


Glu Gly His Val Glu Xaa Val Leu Ala Leu Leu Glu Lys Glu Ala Ser 
        515                 520                 525             


Gln Ala Cys Met Xaa Lys Lys Gly Phe Xaa Pro Leu His Val Ala Ala 
    530                 535                 540                 


Lys Tyr Gly Lys Val Arg Val Ala Glu Leu Leu Leu Glu Arg Asp Ala 
545                 550                 555                 560 


His Pro Asn Ala Ala Gly Lys Asn Gly Leu Xaa Pro Leu His Val Ala 
                565                 570                 575     


Val His His Asn Asn Leu Asp Ile Val Lys Leu Leu Leu Pro Arg Gly 
            580                 585                 590         


Gly Ser Pro His Ser Pro Ala Trp Asn Gly Tyr Xaa Pro Leu His Ile 
        595                 600                 605             


Ala Ala Lys Gln Asn Gln Val Glu Val Ala Arg Ser Leu Leu Gln Tyr 
    610                 615                 620                 


Gly Gly Ser Ala Asn Ala Glu Ser Val Gln Gly Val Xaa Pro Leu His 
625                 630                 635                 640 


Leu Ala Ala Gln Glu Gly His Ala Glu Met Val Ala Leu Leu Leu Ser 
                645                 650                 655     


Lys Gln Ala Asn Gly Asn Leu Gly Asn Lys Ser Gly Leu Xaa Pro Leu 
            660                 665                 670         


His Leu Val Ala Gln Glu Gly His Val Pro Val Ala Asp Val Leu Ile 
        675                 680                 685             


Lys His Gly Val Met Val Asp Ala Xaa Xaa Arg Met Gly Tyr Xaa Pro 
    690                 695                 700                 


Leu His Val Ala Ser His Tyr Gly Asn Ile Lys Leu Val Lys Phe Leu 
705                 710                 715                 720 


Leu Gln His Gln Ala Asp Val Asn Ala Lys Xaa Lys Leu Gly Tyr Ser 
                725                 730                 735     


Pro Leu His Gln Ala Ala Gln Gln Gly His Xaa Asp Ile Val Xaa Leu 
            740                 745                 750         


Leu Leu Lys Asn Gly Ala Ser Pro Asn Glu Val Ser Ser Asp Gly Xaa 
        755                 760                 765             


Xaa Pro Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile Ser Val Xaa Asp 
    770                 775                 780                 


Val Leu Lys Val Val Xaa Asp Glu Xaa Ser Phe Val Leu Val Ser Asp 
785                 790                 795                 800 


Lys His Arg Met Ser Phe Pro Glu Xaa Val Asp Glu Ile Leu Asp Val 
                805                 810                 815     


Ser Glu Asp Glu Gly Glu Glu Leu Ile Ser Phe Lys Ala Glu Arg Arg 
            820                 825                 830         


Asp Ser Arg Asp Val Asp Glu Glu Lys Glu Leu Leu Asp Phe Val Pro 
        835                 840                 845             


Lys Leu Asp Gln Val Val Glu Ser Pro Ala Ile Pro Arg Ile Pro Cys 
    850                 855                 860                 


Ala Met Pro Glu Xaa Val Val Ile Arg Ser Glu Glu Gln Glu Gln Ala 
865                 870                 875                 880 


Ser Lys Glu Tyr Asp Glu Asp Ser Leu Ile Pro Ser Ser Pro Ala Xaa 
                885                 890                 895     


Glu Xaa Ser Asp Asn Ile Ser Pro Val Ala Ser Pro Val His Xaa Gly 
            900                 905                 910         


Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg Gly 
        915                 920                 925             


Ser Arg His Asn Gly Leu Arg Val Val Ile Pro Pro Arg Xaa Cys Ala 
    930                 935                 940                 


Ala Pro Xaa Arg Ile Xaa Cys Arg Leu Val Lys Pro Gln Lys Leu Ser 
945                 950                 955                 960 


Xaa Pro Pro Pro Leu Ala Glu Glu Glu Gly Leu Ala Ser Arg Ile Ile 
                965                 970                 975     


Ala Leu Gly Pro Xaa Gly Ala Gln Phe Leu Ser Pro Val Ile Val Glu 
            980                 985                 990         


Ile Pro His Phe Ala Ser His Gly  Arg Gly Asp Arg Glu  Leu Val Val 
        995                 1000                 1005             


Leu Arg  Ser Glu Asn Gly Ser  Val Trp Lys Glu His  Arg Ser Arg 
    1010                 1015                 1020             


Tyr Gly  Glu Ser Tyr Leu Asp  Gln Ile Leu Asn Gly  Met Asp Glu 
    1025                 1030                 1035             


Glu Leu  Gly Ser Leu Glu Glu  Leu Glu Lys Lys Arg  Val Cys Arg 
    1040                 1045                 1050             


Ile Ile  Xaa Xaa Asp Phe Pro  Leu Tyr Phe Val Ile  Met Ser Arg 
    1055                 1060                 1065             


Leu Cys  Gln Asp Tyr Asp Xaa  Ile Gly Pro Glu Gly  Gly Ser Leu 
    1070                 1075                 1080             


Lys Ser  Lys Leu Val Pro Leu  Val Gln Ala Xaa Phe  Pro Glu Asn 
    1085                 1090                 1095             


Ala Val  Xaa Lys Arg Val Lys  Leu Ala Leu Gln Ala  Gln Pro Val 
    1100                 1105                 1110             


Pro Asp  Glu Leu Val Xaa Lys  Leu Leu Gly Asn Gln  Ala Xaa Phe 
    1115                 1120                 1125             


Ser Pro  Ile Val Xaa Val Glu  Pro Arg Arg Arg Lys  Phe His Arg 
    1130                 1135                 1140             


Pro Ile  Gly Leu Arg Ile Pro  Leu Pro Pro Ser Trp  Xaa Asp Asn 
    1145                 1150                 1155             


Pro Arg  Asp Ser Gly Glu Gly  Asp Xaa Xaa Ser Leu  Arg Leu Leu 
    1160                 1165                 1170             


Cys Ser  Val Ile Gly Gly Xaa  Asp Gln Ala Gln Trp  Glu Asp Ile 
    1175                 1180                 1185             


Xaa Gly  Xaa Xaa Lys Leu Val  Tyr Ala Asn Glu Cys  Ala Asn Phe 
    1190                 1195                 1200             


Xaa Xaa  Asn Val Ser Ala Arg  Phe Trp Leu Ser Asp  Cys Pro Arg 
    1205                 1210                 1215             


Xaa Ala  Glu Ala Val Asn Phe  Ala Xaa Leu Leu Tyr  Lys Glu Leu 
    1220                 1225                 1230             


Xaa Ala  Val Pro Tyr Met Ala  Lys Phe Val Ile Phe  Ala Lys Met 
    1235                 1240                 1245             


Asn Asp  Pro Arg Glu Gly Arg  Leu Arg Cys Tyr Cys  Met Xaa Asp 
    1250                 1255                 1260             


Asp Lys  Val Asp Lys Xaa Leu  Glu Gln His Glu Asn  Phe Val Glu 
    1265                 1270                 1275             


Val Ala  Arg Ser Arg Asp Ile  Glu Val Leu Glu Gly  Met Ser Leu 
    1280                 1285                 1290             


Phe Ala  Glu Leu Ser Gly Asn  Leu Val Pro Val Lys  Lys Ala Ala 
    1295                 1300                 1305             


Gln Gln  Arg Ser Phe His Phe  Gln Ser Phe Arg Glu  Asn Arg Leu 
    1310                 1315                 1320             


Ala Met  Pro Val Lys Val Arg  Asp Ser Ser Arg Glu  Pro Gly Gly 
    1325                 1330                 1335             


Ser Leu  Ser Phe Leu Arg Lys  Ala Met Lys Tyr Glu  Asp Xaa Gln 
    1340                 1345                 1350             


His Ile  Leu Cys His Leu Asn  Ile Xaa Met Pro Pro  Cys Ala Lys 
    1355                 1360                 1365             


Gly Ser  Gly Ala Glu Asp Arg  Arg Arg Xaa Pro Xaa  Pro Leu Ala 
    1370                 1375                 1380             


Leu Arg  Tyr Ser Ile Leu Ser  Glu Ser Xaa Pro Gly  Ser Leu Ser 
    1385                 1390                 1395             


Gly Xaa  Glu Gln Ala Glu Met  Lys Met Ala Val Ile  Ser Glu His 
    1400                 1405                 1410             


Leu Gly  Leu Ser Trp Ala Glu  Leu Ala Arg Glu Leu  Gln Phe Ser 
    1415                 1420                 1425             


Val Glu  Asp Ile Asn Arg Ile  Arg Val Glu Asn Pro  Asn Ser Leu 
    1430                 1435                 1440             


Leu Glu  Gln Ser Val Ala Leu  Leu Asn Leu Trp Val  Ile Arg Glu 
    1445                 1450                 1455             


Gly Gln  Asn Ala Asn Met Glu  Asn Leu Tyr Xaa Ala  Leu Gln Ser 
    1460                 1465                 1470             


Ile Asp  Arg Gly Glu Ile Val  Asn Met Leu Glu Gly  Ser Gly Arg 
    1475                 1480                 1485             


Gln Ser  Arg Asn Leu Lys Pro  Asp Arg Arg His Xaa  Asp Arg Asp 
    1490                 1495                 1500             


Tyr Ser  Leu Ser Pro Ser Gln  Met Asn Gly Tyr Ser  Ser Leu Gln 
    1505                 1510                 1515             


Asp Glu  Leu Leu Ser Pro Ala  Ser Leu Gly Cys Ala  Leu Ser Ser 
    1520                 1525                 1530             


Pro Leu  Arg Ala Asp Gln Tyr  Trp Asn Glu Val Ala  Val Leu Asp 
    1535                 1540                 1545             


Ala Ile  Pro Leu Ala Ala Xaa  Glu His Asp Xaa Met  Leu Glu Met 
    1550                 1555                 1560             


Ser Asp  Met Gln Val Trp Ser  Ala Gly Leu Xaa Pro  Ser Leu Val 
    1565                 1570                 1575             


Xaa Ala  Glu Asp Ser Ser Leu  Glu Cys Ser Lys Ala  Glu Asp Ser 
    1580                 1585                 1590             


Asp Ala  Xaa Gly His Glu Trp  Lys Leu Glu Gly Ala  Leu Ser Glu 
    1595                 1600                 1605             


Glu Pro  Arg Gly Pro Glu Leu  Gly Ser Leu Glu Leu  Val Glu Asp 
    1610                 1615                 1620             


Asp Xaa  Val Asp Ser Asp Ala  Xaa Asn Gly Leu Ile  Asp Leu Leu 
    1625                 1630                 1635             


Glu Gln  Glu Glu Gly Gln Arg  Ser Glu Glu Lys Leu  Pro Gly Ser 
    1640                 1645                 1650             


Lys Arg  Gln Asp Asp Ala Xaa  Gly Ala Gly Gln Asp  Ser Glu Asn 
    1655                 1660                 1665             


Glu Val  Ser Leu Val Ser Gly  His Gln Arg Gly Gln  Ala Arg Ile 
    1670                 1675                 1680             


Xaa His  Ser Pro Xaa Val Ser  Gln Val Xaa Glu Arg  Ser Gln Asp 
    1685                 1690                 1695             


Arg Leu  Gln Asp Trp Asp Ala  Asp Gly Ser Ile Val  Ser Tyr Leu 
    1700                 1705                 1710             


Gln Asp  Ala Ala Gln Gly Ser  Trp Gln Glu Glu Val  Xaa Gln Gly 
    1715                 1720                 1725             


Pro His  Ser Phe Gln Gly Xaa  Ser Xaa Met Xaa Glu  Gly Leu Glu 
    1730                 1735                 1740             


Pro Gly  Gly Ser Gln Glu Tyr  Glu Lys Val Leu Val  Ser Val Ser 
    1745                 1750                 1755             


Glu His  Xaa Trp Xaa Glu Gln  Pro Glu Ala Glu Ser  Ser Gln Ala 
    1760                 1765                 1770             


Asp Arg  Asp Arg Arg Gln Gln  Gly Gln Glu Glu Gln  Val Gln Glu 
    1775                 1780                 1785             


Ala Lys  Asn Xaa Phe Xaa Gln  Val Val Gln Gly Asn  Glu Phe Gln 
    1790                 1795                 1800             


Asn Ile  Pro Gly Glu Gln Val  Xaa Glu Glu Gln Phe  Xaa Asp Glu 
    1805                 1810                 1815             


Gln Gly  Asn Ile Val Xaa Lys  Lys Ile Ile Arg Lys  Val Val Arg 
    1820                 1825                 1830             


Gln Ile  Asp Leu Ser Ser Ala  Asp Ala Ala Gln Glu  His Glu Glu 
    1835                 1840                 1845             


Val Glu  Leu Arg Gly Ser Gly  Leu Gln Pro Asp Leu  Ile Glu Gly 
    1850                 1855                 1860             


Arg Lys  Gly Ala Gln Ile Val  Lys Arg Ala Ser Leu  Lys Arg Gly 
    1865                 1870                 1875             


Lys Gln  
    1880 


<210> 2288
<211> 1881
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1189)..(1189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1191)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1234)..(1234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1262)..(1262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1378)..(1378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1380)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1393)..(1393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1400)..(1400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1469)..(1469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1500)..(1500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1559)..(1559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1579)..(1579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1625)..(1625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1631)..(1631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1660)..(1660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1684)..(1684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1688)..(1688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1693)..(1693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1726)..(1726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1735)..(1735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1737)..(1737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1739)..(1739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1763)..(1763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1792)..(1792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1794)..(1794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1811)..(1811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1816)..(1816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1824)..(1824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1850)..(1850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1876)..(1876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1878)..(1878)
<223> Selenocysteine

<400> 2288
Met Pro Tyr Ser Val Gly Phe Arg Glu Ala Asp Ala Ala Xaa Ser Phe 
1               5                   10                  15      


Leu Arg Ala Ala Arg Ser Gly Asn Leu Asp Lys Ala Leu Asp His Leu 
            20                  25                  30          


Arg Asn Gly Val Asp Ile Asn Xaa Cys Asn Gln Asn Gly Leu Asn Gly 
        35                  40                  45              


Leu His Leu Ala Ser Lys Glu Gly His Val Lys Met Val Val Glu Leu 
    50                  55                  60                  


Leu His Lys Glu Ile Ile Leu Glu Xaa Xaa Xaa Lys Lys Gly Asn Xaa 
65                  70                  75                  80  


Ala Leu His Ile Ala Ala Leu Ala Gly Gln Asp Glu Val Val Arg Glu 
                85                  90                  95      


Leu Val Asn Tyr Gly Ala Asn Val Asn Ala Gln Ser Gln Lys Gly Phe 
            100                 105                 110         


Xaa Pro Leu Tyr Met Ala Ala Gln Glu Asn His Leu Glu Val Val Lys 
        115                 120                 125             


Phe Leu Leu Glu Asn Gly Ala Asn Gln Asn Val Ala Xaa Glu Asp Gly 
    130                 135                 140                 


Phe Xaa Pro Leu Ala Val Ala Leu Gln Gln Gly His Glu Asn Val Val 
145                 150                 155                 160 


Ala His Leu Ile Asn Tyr Gly Xaa Lys Gly Lys Val Arg Leu Pro Ala 
                165                 170                 175     


Leu His Ile Ala Ala Arg Asn Asp Asp Xaa Arg Xaa Ala Ala Val Leu 
            180                 185                 190         


Leu Gln Asn Asp Pro Asn Pro Asp Val Leu Ser Lys Xaa Gly Phe Xaa 
        195                 200                 205             


Pro Leu His Ile Ala Ala His Tyr Glu Asn Leu Asn Val Ala Gln Leu 
    210                 215                 220                 


Leu Leu Asn Arg Gly Ala Ser Val Asn Phe Xaa Pro Gln Asn Gly Ile 
225                 230                 235                 240 


Xaa Pro Leu His Ile Ala Ser Arg Arg Gly Asn Val Ile Met Val Arg 
                245                 250                 255     


Leu Leu Leu Asp Arg Gly Ala Gln Ile Glu Xaa Lys Xaa Lys Asp Glu 
            260                 265                 270         


Leu Xaa Pro Leu His Cys Ala Ala Arg Asn Gly His Val Arg Ile Ser 
        275                 280                 285             


Glu Ile Leu Leu Asp His Gly Ala Pro Ile Gln Ala Lys Xaa Lys Asn 
    290                 295                 300                 


Gly Leu Ser Pro Ile His Met Ala Ala Gln Gly Asp His Leu Asp Cys 
305                 310                 315                 320 


Val Arg Leu Leu Leu Gln Tyr Asp Ala Glu Ile Asp Asp Ile Xaa Leu 
                325                 330                 335     


Asp His Leu Xaa Pro Leu His Val Ala Ala His Cys Gly His His Arg 
            340                 345                 350         


Val Ala Lys Val Leu Leu Asp Lys Gly Ala Lys Pro Asn Ser Arg Ala 
        355                 360                 365             


Leu Asn Gly Phe Xaa Pro Leu His Ile Ala Cys Lys Lys Asn His Val 
    370                 375                 380                 


Arg Val Met Glu Leu Leu Leu Lys Xaa Gly Ala Ser Ile Asp Ala Val 
385                 390                 395                 400 


Xaa Glu Ser Gly Leu Xaa Pro Leu His Val Ala Ser Phe Met Gly His 
                405                 410                 415     


Leu Pro Ile Val Lys Asn Leu Leu Gln Arg Gly Ala Ser Pro Asn Val 
            420                 425                 430         


Ser Asn Val Lys Val Glu Xaa Pro Leu His Met Ala Ala Arg Ala Gly 
        435                 440                 445             


His Xaa Glu Val Ala Lys Tyr Leu Leu Gln Asn Lys Ala Lys Val Asn 
    450                 455                 460                 


Ala Lys Ala Lys Asp Asp Gln Xaa Pro Leu His Cys Ala Ala Arg Ile 
465                 470                 475                 480 


Gly His Xaa Asn Met Val Lys Leu Leu Leu Glu Asn Asn Ala Asn Pro 
                485                 490                 495     


Asn Leu Ala Xaa Xaa Ala Gly His Xaa Pro Leu His Ile Ala Ala Arg 
            500                 505                 510         


Glu Gly His Val Glu Xaa Val Leu Ala Leu Leu Glu Lys Glu Ala Ser 
        515                 520                 525             


Gln Ala Cys Met Xaa Lys Lys Gly Phe Xaa Pro Leu His Val Ala Ala 
    530                 535                 540                 


Lys Tyr Gly Lys Val Arg Val Ala Glu Leu Leu Leu Glu Arg Asp Ala 
545                 550                 555                 560 


His Pro Asn Ala Ala Gly Lys Asn Gly Leu Xaa Pro Leu His Val Ala 
                565                 570                 575     


Val His His Asn Asn Leu Asp Ile Val Lys Leu Leu Leu Pro Arg Gly 
            580                 585                 590         


Gly Ser Pro His Ser Pro Ala Trp Asn Gly Tyr Xaa Pro Leu His Ile 
        595                 600                 605             


Ala Ala Lys Gln Asn Gln Val Glu Val Ala Arg Ser Leu Leu Gln Tyr 
    610                 615                 620                 


Gly Gly Ser Ala Asn Ala Glu Ser Val Gln Gly Val Xaa Pro Leu His 
625                 630                 635                 640 


Leu Ala Ala Gln Glu Gly His Ala Glu Met Val Ala Leu Leu Leu Ser 
                645                 650                 655     


Lys Gln Ala Asn Gly Asn Leu Gly Asn Lys Ser Gly Leu Xaa Pro Leu 
            660                 665                 670         


His Leu Val Ala Gln Glu Gly His Val Pro Val Ala Asp Val Leu Ile 
        675                 680                 685             


Lys His Gly Val Met Val Asp Ala Xaa Xaa Arg Met Gly Tyr Xaa Pro 
    690                 695                 700                 


Leu His Val Ala Ser His Tyr Gly Asn Ile Lys Leu Val Lys Phe Leu 
705                 710                 715                 720 


Leu Gln His Gln Ala Asp Val Asn Ala Lys Xaa Lys Leu Gly Tyr Ser 
                725                 730                 735     


Pro Leu His Gln Ala Ala Gln Gln Gly His Xaa Asp Ile Val Xaa Leu 
            740                 745                 750         


Leu Leu Lys Asn Gly Ala Ser Pro Asn Glu Val Ser Ser Asp Gly Xaa 
        755                 760                 765             


Xaa Pro Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile Ser Val Xaa Asp 
    770                 775                 780                 


Val Leu Lys Val Val Xaa Asp Glu Xaa Ser Phe Val Leu Val Ser Asp 
785                 790                 795                 800 


Lys His Arg Met Ser Phe Pro Glu Xaa Val Asp Glu Ile Leu Asp Val 
                805                 810                 815     


Ser Glu Asp Glu Gly Glu Glu Leu Ile Ser Phe Lys Ala Glu Arg Arg 
            820                 825                 830         


Asp Ser Arg Asp Val Asp Glu Glu Lys Glu Leu Leu Asp Phe Val Pro 
        835                 840                 845             


Lys Leu Asp Gln Val Val Glu Ser Pro Ala Ile Pro Arg Ile Pro Cys 
    850                 855                 860                 


Ala Met Pro Glu Xaa Val Val Ile Arg Ser Glu Glu Gln Glu Gln Ala 
865                 870                 875                 880 


Ser Lys Glu Tyr Asp Glu Asp Ser Leu Ile Pro Ser Ser Pro Ala Xaa 
                885                 890                 895     


Glu Xaa Ser Asp Asn Ile Ser Pro Val Ala Ser Pro Val His Xaa Gly 
            900                 905                 910         


Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg Gly 
        915                 920                 925             


Ser Arg His Asn Gly Leu Arg Val Val Ile Pro Pro Arg Xaa Cys Ala 
    930                 935                 940                 


Ala Pro Xaa Arg Ile Xaa Cys Arg Leu Val Lys Pro Gln Lys Leu Ser 
945                 950                 955                 960 


Xaa Pro Pro Pro Leu Ala Glu Glu Glu Gly Leu Ala Ser Arg Ile Ile 
                965                 970                 975     


Ala Leu Gly Pro Xaa Gly Ala Gln Phe Leu Ser Pro Val Ile Val Glu 
            980                 985                 990         


Ile Pro His Phe Ala Ser His Gly  Arg Gly Asp Arg Glu  Leu Val Val 
        995                 1000                 1005             


Leu Arg  Ser Glu Asn Gly Ser  Val Trp Lys Glu His  Arg Ser Arg 
    1010                 1015                 1020             


Tyr Gly  Glu Ser Tyr Leu Asp  Gln Ile Leu Asn Gly  Met Asp Glu 
    1025                 1030                 1035             


Glu Leu  Gly Ser Leu Glu Glu  Leu Glu Lys Lys Arg  Val Cys Arg 
    1040                 1045                 1050             


Ile Ile  Xaa Xaa Asp Phe Pro  Leu Tyr Phe Val Ile  Met Ser Arg 
    1055                 1060                 1065             


Leu Cys  Gln Asp Tyr Asp Xaa  Ile Gly Pro Glu Gly  Gly Ser Leu 
    1070                 1075                 1080             


Lys Ser  Lys Leu Val Pro Leu  Val Gln Ala Xaa Phe  Pro Glu Asn 
    1085                 1090                 1095             


Ala Val  Xaa Lys Arg Val Lys  Leu Ala Leu Gln Ala  Gln Pro Val 
    1100                 1105                 1110             


Pro Asp  Glu Leu Val Xaa Lys  Leu Leu Gly Asn Gln  Ala Xaa Phe 
    1115                 1120                 1125             


Ser Pro  Ile Val Xaa Val Glu  Pro Arg Arg Arg Lys  Phe His Arg 
    1130                 1135                 1140             


Pro Ile  Gly Leu Arg Ile Pro  Leu Pro Pro Ser Trp  Xaa Asp Asn 
    1145                 1150                 1155             


Pro Arg  Asp Ser Gly Glu Gly  Asp Xaa Xaa Ser Leu  Arg Leu Leu 
    1160                 1165                 1170             


Cys Ser  Val Ile Gly Gly Xaa  Asp Gln Ala Gln Trp  Glu Asp Ile 
    1175                 1180                 1185             


Xaa Gly  Xaa Xaa Lys Leu Val  Tyr Ala Asn Glu Cys  Ala Asn Phe 
    1190                 1195                 1200             


Xaa Xaa  Asn Val Ser Ala Arg  Phe Trp Leu Ser Asp  Cys Pro Arg 
    1205                 1210                 1215             


Xaa Ala  Glu Ala Val Asn Phe  Ala Xaa Leu Leu Tyr  Lys Glu Leu 
    1220                 1225                 1230             


Xaa Ala  Val Pro Tyr Met Ala  Lys Phe Val Ile Phe  Ala Lys Met 
    1235                 1240                 1245             


Asn Asp  Pro Arg Glu Gly Arg  Leu Arg Cys Tyr Cys  Met Xaa Asp 
    1250                 1255                 1260             


Asp Lys  Val Asp Lys Xaa Leu  Glu Gln His Glu Asn  Phe Val Glu 
    1265                 1270                 1275             


Val Ala  Arg Ser Arg Asp Ile  Glu Val Leu Glu Gly  Met Ser Leu 
    1280                 1285                 1290             


Phe Ala  Glu Leu Ser Gly Asn  Leu Val Pro Val Lys  Lys Ala Ala 
    1295                 1300                 1305             


Gln Gln  Arg Ser Phe His Phe  Gln Ser Phe Arg Glu  Asn Arg Leu 
    1310                 1315                 1320             


Ala Met  Pro Val Lys Val Arg  Asp Ser Ser Arg Glu  Pro Gly Gly 
    1325                 1330                 1335             


Ser Leu  Ser Phe Leu Arg Lys  Ala Met Lys Tyr Glu  Asp Xaa Gln 
    1340                 1345                 1350             


His Ile  Leu Cys His Leu Asn  Ile Xaa Met Pro Pro  Cys Ala Lys 
    1355                 1360                 1365             


Gly Ser  Gly Ala Glu Asp Arg  Arg Arg Xaa Pro Xaa  Pro Leu Ala 
    1370                 1375                 1380             


Leu Arg  Tyr Ser Ile Leu Ser  Glu Ser Xaa Pro Gly  Ser Leu Ser 
    1385                 1390                 1395             


Gly Xaa  Glu Gln Ala Glu Met  Lys Met Ala Val Ile  Ser Glu His 
    1400                 1405                 1410             


Leu Gly  Leu Ser Trp Ala Glu  Leu Ala Arg Glu Leu  Gln Phe Ser 
    1415                 1420                 1425             


Val Glu  Asp Ile Asn Arg Ile  Arg Val Glu Asn Pro  Asn Ser Leu 
    1430                 1435                 1440             


Leu Glu  Gln Ser Val Ala Leu  Leu Asn Leu Trp Val  Ile Arg Glu 
    1445                 1450                 1455             


Gly Gln  Asn Ala Asn Met Glu  Asn Leu Tyr Xaa Ala  Leu Gln Ser 
    1460                 1465                 1470             


Ile Asp  Arg Gly Glu Ile Val  Asn Met Leu Glu Gly  Ser Gly Arg 
    1475                 1480                 1485             


Gln Ser  Arg Asn Leu Lys Pro  Asp Arg Arg His Xaa  Asp Arg Asp 
    1490                 1495                 1500             


Tyr Ser  Leu Ser Pro Ser Gln  Met Asn Gly Tyr Ser  Ser Leu Gln 
    1505                 1510                 1515             


Asp Glu  Leu Leu Ser Pro Ala  Ser Leu Gly Cys Ala  Leu Ser Ser 
    1520                 1525                 1530             


Pro Leu  Arg Ala Asp Gln Tyr  Trp Asn Glu Val Ala  Val Leu Asp 
    1535                 1540                 1545             


Ala Ile  Pro Leu Ala Ala Xaa  Glu His Asp Xaa Met  Leu Glu Met 
    1550                 1555                 1560             


Ser Asp  Met Gln Val Trp Ser  Ala Gly Leu Xaa Pro  Ser Leu Val 
    1565                 1570                 1575             


Xaa Ala  Glu Asp Ser Ser Leu  Glu Cys Ser Lys Ala  Glu Asp Ser 
    1580                 1585                 1590             


Asp Ala  Xaa Gly His Glu Trp  Lys Leu Glu Gly Ala  Leu Ser Glu 
    1595                 1600                 1605             


Glu Pro  Arg Gly Pro Glu Leu  Gly Ser Leu Glu Leu  Val Glu Asp 
    1610                 1615                 1620             


Asp Xaa  Val Asp Ser Asp Ala  Xaa Asn Gly Leu Ile  Asp Leu Leu 
    1625                 1630                 1635             


Glu Gln  Glu Glu Gly Gln Arg  Ser Glu Glu Lys Leu  Pro Gly Ser 
    1640                 1645                 1650             


Lys Arg  Gln Asp Asp Ala Xaa  Gly Ala Gly Gln Asp  Ser Glu Asn 
    1655                 1660                 1665             


Glu Val  Ser Leu Val Ser Gly  His Gln Arg Gly Gln  Ala Arg Ile 
    1670                 1675                 1680             


Xaa His  Ser Pro Xaa Val Ser  Gln Val Xaa Glu Arg  Ser Gln Asp 
    1685                 1690                 1695             


Arg Leu  Gln Asp Trp Asp Ala  Asp Gly Ser Ile Val  Ser Tyr Leu 
    1700                 1705                 1710             


Gln Asp  Ala Ala Gln Gly Ser  Trp Gln Glu Glu Val  Xaa Gln Gly 
    1715                 1720                 1725             


Pro His  Ser Phe Gln Gly Xaa  Ser Xaa Met Xaa Glu  Gly Leu Glu 
    1730                 1735                 1740             


Pro Gly  Gly Ser Gln Glu Tyr  Glu Lys Val Leu Val  Ser Val Ser 
    1745                 1750                 1755             


Glu His  Xaa Trp Xaa Glu Gln  Pro Glu Ala Glu Ser  Ser Gln Ala 
    1760                 1765                 1770             


Asp Arg  Asp Arg Arg Gln Gln  Gly Gln Glu Glu Gln  Val Gln Glu 
    1775                 1780                 1785             


Ala Lys  Asn Xaa Phe Xaa Gln  Val Val Gln Gly Asn  Glu Phe Gln 
    1790                 1795                 1800             


Asn Ile  Pro Gly Glu Gln Val  Xaa Glu Glu Gln Phe  Xaa Asp Glu 
    1805                 1810                 1815             


Gln Gly  Asn Ile Val Xaa Lys  Lys Ile Ile Arg Lys  Val Val Arg 
    1820                 1825                 1830             


Gln Ile  Asp Leu Ser Ser Ala  Asp Ala Ala Gln Glu  His Glu Glu 
    1835                 1840                 1845             


Val Xaa  Val Glu Gly Pro Leu  Glu Asp Pro Ser Glu  Leu Glu Val 
    1850                 1855                 1860             


Asp Ile  Asp Tyr Phe Met Lys  His Ser Lys Asp His  Xaa Ser Xaa 
    1865                 1870                 1875             


Pro Asn  Pro 
    1880     


<210> 2289
<211> 109
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<400> 2289
Met Trp Xaa Phe Val Xaa Gln Leu Leu Val Xaa Leu Val Leu Leu Ser 
1               5                   10                  15      


Phe Phe Leu Val Ser Cys Gln Asn Val Met His Ile Val Arg Gly Ser 
            20                  25                  30          


Leu Cys Phe Val Leu Lys His Ile His Gln Glu Leu Asp Lys Glu Leu 
        35                  40                  45              


Gly Glu Ser Glu Gly Leu Ser Asp Asp Glu Glu Xaa Ile Ser Xaa Arg 
    50                  55                  60                  


Val Val Arg Arg Arg Val Phe Leu Lys Gly Asn Glu Phe Gln Asn Ile 
65                  70                  75                  80  


Pro Gly Glu Gln Val Xaa Glu Glu Gln Phe Xaa Asp Glu Gln Gly Asn 
                85                  90                  95      


Ile Val Xaa Lys Lys Asp His Xaa Ser Xaa Pro Asn Pro 
            100                 105                 


<210> 2290
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 2290
Met Trp Xaa Phe Val Xaa Gln Leu Leu Val Xaa Leu Val Leu Leu Ser 
1               5                   10                  15      


Phe Phe Leu Val Ser Cys Gln Asn Val Met His Ile Val Arg Gly Ser 
            20                  25                  30          


Leu Cys Phe Val Leu Lys His Ile His Gln Glu Leu Asp Lys Glu Leu 
        35                  40                  45              


Gly Glu Ser Glu Gly Leu Ser Asp Asp Glu Glu Xaa Ile Ser Xaa Arg 
    50                  55                  60                  


Val Val Arg Arg Arg Val Phe Leu Lys Gly Asn Glu Phe Gln Asn Ile 
65                  70                  75                  80  


Pro Gly Glu Gln Val Xaa Glu Glu Gln Phe Xaa Asp Glu Gln Gly Asn 
                85                  90                  95      


Ile Val Xaa Lys Lys Ile Ile Arg Lys Val Val Arg Gln Ile Asp Leu 
            100                 105                 110         


Ser Ser Ala Asp Ala Ala Gln Glu His Glu Glu Asp His Xaa Ser Xaa 
        115                 120                 125             


Pro Asn Pro 
    130     


<210> 2291
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<400> 2291
Met Trp Xaa Phe Val Xaa Gln Leu Leu Val Xaa Leu Val Leu Leu Ser 
1               5                   10                  15      


Phe Phe Leu Val Ser Cys Gln Asn Val Met His Ile Val Arg Gly Ser 
            20                  25                  30          


Leu Cys Phe Val Leu Lys His Ile His Gln Glu Leu Asp Lys Glu Leu 
        35                  40                  45              


Gly Glu Ser Glu Gly Leu Ser Asp Asp Glu Glu Xaa Ile Ser Xaa Arg 
    50                  55                  60                  


Val Val Arg Arg Arg Val Phe Leu Lys Gly Asn Glu Phe Gln Asn Ile 
65                  70                  75                  80  


Pro Gly Glu Gln Val Xaa Glu Glu Gln Phe Xaa Asp Glu Gln Gly Asn 
                85                  90                  95      


Ile Val Xaa Lys Lys Ile Ile Arg Lys Val Val Arg Gln Ile Asp Leu 
            100                 105                 110         


Ser Ser Ala Asp Ala Ala Gln Glu His Glu Glu Val Glu Leu Arg Gly 
        115                 120                 125             


Ser Gly Leu Gln Pro Asp Leu Ile Glu Gly Arg Lys Gly Ala Gln Ile 
    130                 135                 140                 


Val Lys Arg Ala Ser Leu Lys Arg Gly Lys Gln 
145                 150                 155 


<210> 2292
<211> 156
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<400> 2292
Met Trp Xaa Phe Val Xaa Gln Leu Leu Val Xaa Leu Val Leu Leu Ser 
1               5                   10                  15      


Phe Phe Leu Val Ser Cys Gln Asn Val Met His Ile Val Arg Gly Ser 
            20                  25                  30          


Leu Cys Phe Val Leu Lys His Ile His Gln Glu Leu Asp Lys Glu Leu 
        35                  40                  45              


Gly Glu Ser Glu Gly Leu Ser Asp Asp Glu Glu Xaa Ile Ser Xaa Arg 
    50                  55                  60                  


Val Val Arg Arg Arg Val Phe Leu Lys Gly Asn Glu Phe Gln Asn Ile 
65                  70                  75                  80  


Pro Gly Glu Gln Val Xaa Glu Glu Gln Phe Xaa Asp Glu Gln Gly Asn 
                85                  90                  95      


Ile Val Xaa Lys Lys Ile Ile Arg Lys Val Val Arg Gln Ile Asp Leu 
            100                 105                 110         


Ser Ser Ala Asp Ala Ala Gln Glu His Glu Glu Val Xaa Val Glu Gly 
        115                 120                 125             


Pro Leu Glu Asp Pro Ser Glu Leu Glu Val Asp Ile Asp Tyr Phe Met 
    130                 135                 140                 


Lys His Ser Lys Asp His Xaa Ser Xaa Pro Asn Pro 
145                 150                 155     


<210> 2293
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<400> 2293
Met Trp Xaa Phe Val Xaa Gln Leu Leu Val Xaa Leu Val Leu Leu Ser 
1               5                   10                  15      


Phe Phe Leu Val Ser Cys Gln Asn Val Met His Ile Val Arg Gly Ser 
            20                  25                  30          


Leu Cys Phe Val Leu Lys His Ile His Gln Glu Leu Asp Lys Glu Leu 
        35                  40                  45              


Gly Glu Ser Glu Gly Leu Ser Asp Asp Glu Glu Xaa Ile Ser Xaa Arg 
    50                  55                  60                  


Val Val Arg Arg Arg Val Phe Leu Lys Gly Asn Glu Phe Gln Asn Ile 
65                  70                  75                  80  


Pro Gly Glu Gln Val Xaa Glu Glu Gln Phe Xaa Asp Glu Gln Gly Asn 
                85                  90                  95      


Ile Val Xaa Lys Lys Val Glu Leu Arg Gly Ser Gly Leu Gln Pro Asp 
            100                 105                 110         


Leu 
    


<210> 2294
<211> 177
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<400> 2294
Xaa Glu Asp Xaa Gln His Ile Leu Cys His Leu Asn Ile Xaa Met Pro 
1               5                   10                  15      


Pro Cys Ala Lys Gly Ser Gly Ala Glu Asp Arg Arg Arg Xaa Pro Xaa 
            20                  25                  30          


Pro Leu Ala Leu Arg Tyr Ser Ile Leu Ser Glu Ser Xaa Pro Gly Ser 
        35                  40                  45              


Leu Ser Gly Xaa Glu Gln Ala Glu Met Lys Met Ala Val Ile Ser Glu 
    50                  55                  60                  


His Leu Gly Leu Ser Trp Ala Glu Leu Ala Arg Glu Leu Gln Phe Ser 
65                  70                  75                  80  


Val Glu Asp Ile Asn Arg Ile Arg Val Glu Asn Pro Asn Ser Leu Leu 
                85                  90                  95      


Glu Gln Ser Val Ala Leu Leu Asn Leu Trp Val Ile Arg Glu Gly Gln 
            100                 105                 110         


Asn Ala Asn Met Glu Asn Leu Tyr Xaa Ala Leu Gln Ser Ile Asp Arg 
        115                 120                 125             


Gly Glu Ile Val Asn Met Leu Glu Gly Ser Gly Arg Gln Ser Arg Asn 
    130                 135                 140                 


Leu Lys Pro Asp Arg Arg His Xaa Asp Arg Asp Tyr Ser Leu Ser Pro 
145                 150                 155                 160 


Ser Gln Met Asn Gly Gly Arg Ser Glu Val Arg Arg Glu Ala Ala Arg 
                165                 170                 175     


Phe 
    


<210> 2295
<211> 1040
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<400> 2295
Xaa Ile Lys His Gly Val Met Val Asp Ala Xaa Xaa Arg Met Gly Tyr 
1               5                   10                  15      


Xaa Pro Leu His Val Ala Ser His Tyr Gly Asn Ile Lys Leu Val Lys 
            20                  25                  30          


Phe Leu Leu Gln His Gln Ala Asp Val Asn Ala Lys Xaa Lys Leu Gly 
        35                  40                  45              


Tyr Ser Pro Leu His Gln Ala Ala Gln Gln Gly His Xaa Asp Ile Val 
    50                  55                  60                  


Xaa Leu Leu Leu Lys Asn Gly Ala Ser Pro Asn Glu Val Ser Ser Asp 
65                  70                  75                  80  


Gly Xaa Xaa Pro Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile Ser Val 
                85                  90                  95      


Xaa Asp Val Leu Lys Val Val Xaa Asp Glu Xaa Ser Phe Val Leu Val 
            100                 105                 110         


Ser Asp Lys His Arg Met Ser Phe Pro Glu Xaa Val Asp Glu Ile Leu 
        115                 120                 125             


Asp Val Ser Glu Asp Glu Gly Xaa Ala His Ile Xaa Ile Met Gly Glu 
    130                 135                 140                 


Glu Leu Ile Ser Phe Lys Ala Glu Arg Arg Asp Ser Arg Asp Val Asp 
145                 150                 155                 160 


Glu Glu Lys Glu Leu Leu Asp Phe Val Pro Lys Leu Asp Gln Val Val 
                165                 170                 175     


Glu Ser Pro Ala Ile Pro Arg Ile Pro Cys Ala Met Pro Glu Xaa Val 
            180                 185                 190         


Val Ile Arg Ser Glu Glu Gln Glu Gln Ala Ser Lys Glu Tyr Asp Glu 
        195                 200                 205             


Asp Ser Leu Ile Pro Ser Ser Pro Ala Xaa Glu Xaa Ser Asp Asn Ile 
    210                 215                 220                 


Ser Pro Val Ala Ser Pro Val His Xaa Gly Phe Leu Val Ser Phe Met 
225                 230                 235                 240 


Val Asp Ala Arg Gly Gly Ser Met Arg Gly Ser Arg His Asn Gly Leu 
                245                 250                 255     


Arg Val Val Ile Pro Pro Arg Xaa Cys Ala Ala Pro Xaa Arg Ile Xaa 
            260                 265                 270         


Cys Arg Leu Val Lys Pro Gln Lys Leu Ser Xaa Pro Pro Pro Leu Ala 
        275                 280                 285             


Glu Glu Glu Gly Leu Ala Ser Arg Ile Ile Ala Leu Gly Pro Xaa Gly 
    290                 295                 300                 


Ala Gln Phe Leu Ser Pro Val Ile Val Glu Ile Pro His Phe Ala Ser 
305                 310                 315                 320 


His Gly Arg Gly Asp Arg Glu Leu Val Val Leu Arg Ser Glu Asn Gly 
                325                 330                 335     


Ser Val Trp Lys Glu His Arg Ser Arg Tyr Gly Glu Ser Tyr Leu Asp 
            340                 345                 350         


Gln Ile Leu Asn Gly Met Asp Glu Glu Leu Gly Ser Leu Glu Glu Leu 
        355                 360                 365             


Glu Lys Lys Arg Val Cys Arg Ile Ile Xaa Xaa Asp Phe Pro Leu Tyr 
    370                 375                 380                 


Phe Val Ile Met Ser Arg Leu Cys Gln Asp Tyr Asp Xaa Ile Gly Pro 
385                 390                 395                 400 


Glu Gly Gly Ser Leu Lys Ser Lys Leu Val Pro Leu Val Gln Ala Xaa 
                405                 410                 415     


Phe Pro Glu Asn Ala Val Xaa Lys Arg Val Lys Leu Ala Leu Gln Ala 
            420                 425                 430         


Gln Pro Val Pro Asp Glu Leu Val Xaa Lys Leu Leu Gly Asn Gln Ala 
        435                 440                 445             


Xaa Phe Ser Pro Ile Val Xaa Val Glu Pro Arg Arg Arg Lys Phe His 
    450                 455                 460                 


Arg Pro Ile Gly Leu Arg Ile Pro Leu Pro Pro Ser Trp Xaa Asp Asn 
465                 470                 475                 480 


Pro Arg Asp Ser Gly Glu Gly Asp Xaa Xaa Ser Leu Arg Leu Leu Cys 
                485                 490                 495     


Ser Val Ile Gly Gly Xaa Asp Gln Ala Gln Trp Glu Asp Ile Xaa Gly 
            500                 505                 510         


Xaa Xaa Lys Leu Val Tyr Ala Asn Glu Cys Ala Asn Phe Xaa Xaa Asn 
        515                 520                 525             


Val Ser Ala Arg Phe Trp Leu Ser Asp Cys Pro Arg Xaa Ala Glu Ala 
    530                 535                 540                 


Val Asn Phe Ala Xaa Leu Leu Tyr Lys Glu Leu Xaa Ala Val Pro Tyr 
545                 550                 555                 560 


Met Ala Lys Phe Val Ile Phe Ala Lys Met Asn Asp Pro Arg Glu Gly 
                565                 570                 575     


Arg Leu Arg Cys Tyr Cys Met Xaa Asp Asp Lys Val Asp Lys Xaa Leu 
            580                 585                 590         


Glu Gln His Glu Asn Phe Val Glu Val Ala Arg Ser Arg Asp Ile Glu 
        595                 600                 605             


Val Leu Glu Gly Met Ser Leu Phe Ala Glu Leu Ser Gly Asn Leu Val 
    610                 615                 620                 


Pro Val Lys Lys Ala Ala Gln Gln Arg Ser Phe His Phe Gln Ser Phe 
625                 630                 635                 640 


Arg Glu Asn Arg Leu Ala Met Pro Val Lys Val Arg Asp Ser Ser Arg 
                645                 650                 655     


Glu Pro Gly Gly Ser Leu Ser Phe Leu Arg Lys Ala Met Lys Tyr Glu 
            660                 665                 670         


Asp Xaa Gln His Ile Leu Cys His Leu Asn Ile Xaa Met Pro Pro Cys 
        675                 680                 685             


Ala Lys Gly Ser Gly Ala Glu Asp Arg Arg Arg Xaa Pro Xaa Pro Leu 
    690                 695                 700                 


Ala Leu Arg Tyr Ser Ile Leu Ser Glu Ser Xaa Pro Gly Ser Leu Ser 
705                 710                 715                 720 


Gly Xaa Glu Gln Ala Glu Met Lys Met Ala Val Ile Ser Glu His Leu 
                725                 730                 735     


Gly Leu Ser Trp Ala Glu Leu Ala Arg Glu Leu Gln Phe Ser Val Glu 
            740                 745                 750         


Asp Ile Asn Arg Ile Arg Val Glu Asn Pro Asn Ser Leu Leu Glu Gln 
        755                 760                 765             


Ser Val Ala Leu Leu Asn Leu Trp Val Ile Arg Glu Gly Gln Asn Ala 
    770                 775                 780                 


Asn Met Glu Asn Leu Tyr Xaa Ala Leu Gln Ser Ile Asp Arg Gly Glu 
785                 790                 795                 800 


Ile Val Asn Met Leu Glu Gly Ser Gly Arg Gln Ser Arg Asn Leu Lys 
                805                 810                 815     


Pro Asp Arg Arg His Xaa Asp Arg Asp Tyr Ser Leu Ser Pro Ser Gln 
            820                 825                 830         


Met Asn Gly His Gln Arg Gly Gln Ala Arg Ile Xaa His Ser Pro Xaa 
        835                 840                 845             


Val Ser Gln Val Xaa Glu Arg Ser Gln Asp Arg Leu Gln Asp Trp Asp 
    850                 855                 860                 


Ala Asp Gly Ser Ile Val Ser Tyr Leu Gln Asp Ala Ala Gln Gly Ser 
865                 870                 875                 880 


Trp Gln Glu Glu Val Xaa Gln Gly Pro His Ser Phe Gln Gly Xaa Ser 
                885                 890                 895     


Xaa Met Xaa Glu Gly Leu Glu Pro Gly Gly Ser Gln Glu Tyr Glu Lys 
            900                 905                 910         


Val Leu Val Ser Val Ser Glu His Xaa Trp Xaa Glu Gln Pro Glu Ala 
        915                 920                 925             


Glu Ser Ser Gln Ala Asp Arg Asp Arg Arg Gln Gln Gly Gln Glu Glu 
    930                 935                 940                 


Gln Val Gln Glu Ala Lys Asn Xaa Phe Xaa Gln Val Val Gln Gly Asn 
945                 950                 955                 960 


Glu Phe Gln Asn Ile Pro Gly Glu Gln Val Xaa Glu Glu Gln Phe Xaa 
                965                 970                 975     


Asp Glu Gln Gly Asn Ile Val Xaa Lys Lys Ile Ile Arg Lys Val Val 
            980                 985                 990         


Arg Gln Ile Asp Leu Ser Ser Ala  Asp Ala Ala Gln Glu  His Glu Glu 
        995                 1000                 1005             


Val Glu  Leu Arg Gly Ser Gly  Leu Gln Pro Asp Leu  Ile Glu Gly 
    1010                 1015                 1020             


Arg Lys  Gly Ala Gln Ile Val  Lys Arg Ala Ser Leu  Lys Arg Gly 
    1025                 1030                 1035             


Lys Gln  
    1040 


<210> 2296
<211> 65
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 2296
Met Ala Ala Gln Glu Asn His Ile Asp Val Val Lys Tyr Leu Leu Glu 
1               5                   10                  15      


Asn Gly Ala Asn Gln Ser Xaa Ala Xaa Glu Asp Gly Phe Xaa Pro Leu 
            20                  25                  30          


Ala Val Ala Leu Gln Gln Gly His Asn Gln Ala Val Ala Ile Leu Leu 
        35                  40                  45              


Glu Asn Asp Xaa Lys Gly Lys Val Arg Leu Pro Ala Leu His Ile Ala 
    50                  55                  60                  


Ala 
65  


<210> 2297
<211> 177
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<400> 2297
Met Ala His Ala Ala Ala Ser Ile Lys Lys Val Arg Glu Ala Asp Leu 
1               5                   10                  15      


Asp Glu Lys Glu Lys Asn Leu Glu Arg Asp Arg Lys Lys Gln Arg Lys 
            20                  25                  30          


Ile Pro Arg Glu Arg Met Glu Arg Lys Arg Lys Ser Asp Ser Asn Ala 
        35                  40                  45              


Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val Glu 
    50                  55                  60                  


Tyr Leu Lys Gly Gly Ile Asp Ile Asn Xaa Cys Asn Gln Asn Gly Leu 
65                  70                  75                  80  


Asn Ala Leu His Leu Ala Ala Lys Glu Gly His Val Gly Leu Val Gln 
                85                  90                  95      


Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser Ala Xaa Lys Lys Gly 
            100                 105                 110         


Asn Xaa Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val Val 
        115                 120                 125             


Lys Val Leu Val Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln Asn 
    130                 135                 140                 


Gly Phe Xaa Pro Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp Val 
145                 150                 155                 160 


Val Lys Tyr Leu Leu Glu Asn Gly Ala Asn Gln Ser Xaa Ala Xaa Glu 
                165                 170                 175     


Asp 
    


<210> 2298
<211> 180
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<400> 2298
Met Asp Ser Asn Ser Ser Pro Glu Glu Val Gln Phe Gln Pro Val Val 
1               5                   10                  15      


Ser Lys Gln Tyr Xaa Phe Lys Met Asn Glu Asp Xaa Gln Glu Glu Pro 
            20                  25                  30          


Gly Lys Ser Glu Glu Glu Lys Asp Ser Glu Ser His Leu Ala Glu Asp 
        35                  40                  45              


Arg His Ala Val Ser Xaa Glu Ala Glu Asp Arg Ser Tyr Asp Lys Leu 
    50                  55                  60                  


Asn Arg Asp Xaa Asp Gln Pro Lys Ile Cys Asp Gly His Gly Cys Glu 
65                  70                  75                  80  


Ala Met Ser Pro Ser Ser Ser Ala Ala Pro Val Ser Ser Gly Leu Gln 
                85                  90                  95      


Ser Pro Xaa Gly Asp Asp Val Asp Glu Gln Pro Val Ile Tyr Lys Glu 
            100                 105                 110         


Ser Leu Ala Leu Gln Gly Xaa His Glu Lys Asp Xaa Glu Gly Glu Glu 
        115                 120                 125             


Leu Asp Val Ser Arg Ala Glu Ser Pro Gln Ala Asp Cys Pro Ser Glu 
    130                 135                 140                 


Ser Phe Ser Ser Ser Ser Ser Leu Pro His Cys Leu Val Ser Glu Gly 
145                 150                 155                 160 


Lys Glu Leu Asp Glu Asp Ile Ser Ala Xaa Ser Ser Ile Gln Lys Xaa 
                165                 170                 175     


Gly His Lys Asn 
            180 


<210> 2299
<211> 112
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 2299
Met Gly Asn Ala Ala Leu Cys Ser Ser Cys His Ala Asp Lys Ser Ile 
1               5                   10                  15      


Arg Ala Gln Gly Asn Met Gln Glu Leu Asp Lys Xaa Pro Asp Tyr Tyr 
            20                  25                  30          


Gly Cys Asn Ser Glu Asp Val Lys Glu Pro Gly Val Trp Ser Asp Ser 
        35                  40                  45              


Asn Ala Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu Asp Lys Val 
    50                  55                  60                  


Val Glu Tyr Leu Lys Gly Gly Ile Asp Ile Asn Xaa Cys Asn Gln Asn 
65                  70                  75                  80  


Gly Leu Asn Ala Leu His Leu Ala Ala Lys Glu Gly His Val Gly Leu 
                85                  90                  95      


Val Gln Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser Ala Xaa Lys 
            100                 105                 110         


<210> 2300
<211> 1872
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1071)..(1071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1189)..(1189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1221)..(1221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1234)..(1234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1268)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1277)..(1277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1357)..(1357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1393)..(1393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1437)..(1437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1451)..(1451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1456)..(1456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1500)..(1500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1509)..(1509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1544)..(1544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1546)..(1546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1553)..(1553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1566)..(1566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1585)..(1585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1587)..(1587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1603)..(1603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1620)..(1620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1638)..(1638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1653)..(1653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1659)..(1659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1690)..(1691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1694)..(1694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1696)..(1696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1699)..(1699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1712)..(1712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1718)..(1718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1729)..(1729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1731)..(1731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1759)..(1759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1796)..(1796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1798)..(1798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1809)..(1809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1815)..(1815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1828)..(1828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1864)..(1864)
<223> Selenocysteine

<400> 2300
Met Met Asn Glu Asp Ala Ala Gln Lys Ser Asp Ser Gly Glu Lys Phe 
1               5                   10                  15      


Asn Gly Ser Ser Gln Arg Arg Lys Arg Pro Lys Lys Ser Asp Ser Asn 
            20                  25                  30          


Ala Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val 
        35                  40                  45              


Glu Tyr Leu Lys Gly Gly Ile Asp Ile Asn Xaa Cys Asn Gln Asn Gly 
    50                  55                  60                  


Leu Asn Ala Leu His Leu Ala Ala Lys Glu Gly His Val Gly Leu Val 
65                  70                  75                  80  


Gln Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser Ala Xaa Lys Lys 
                85                  90                  95      


Gly Asn Xaa Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val 
            100                 105                 110         


Val Lys Val Leu Val Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln 
        115                 120                 125             


Asn Gly Phe Xaa Pro Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp 
    130                 135                 140                 


Val Val Lys Tyr Leu Leu Glu Asn Gly Ala Asn Gln Ser Xaa Ala Xaa 
145                 150                 155                 160 


Glu Asp Gly Phe Xaa Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn 
                165                 170                 175     


Gln Ala Val Ala Ile Leu Leu Glu Asn Asp Xaa Lys Gly Lys Val Arg 
            180                 185                 190         


Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp Xaa Lys Ser Ala 
        195                 200                 205             


Ala Leu Leu Leu Gln Asn Asp His Asn Ala Asp Val Gln Ser Lys Met 
    210                 215                 220                 


Met Val Asn Arg Xaa Xaa Glu Ser Gly Phe Xaa Pro Leu His Ile Ala 
225                 230                 235                 240 


Ala His Tyr Gly Asn Val Asn Val Ala Xaa Leu Leu Leu Asn Arg Gly 
                245                 250                 255     


Ala Ala Val Asp Phe Xaa Ala Arg Asn Gly Ile Xaa Pro Leu His Val 
            260                 265                 270         


Ala Ser Lys Arg Gly Asn Xaa Asn Met Val Lys Leu Leu Leu Asp Arg 
        275                 280                 285             


Gly Gly Gln Ile Asp Ala Lys Xaa Arg Asp Gly Leu Xaa Pro Leu His 
    290                 295                 300                 


Cys Ala Ala Arg Ser Gly His Asp Gln Val Val Glu Leu Leu Leu Glu 
305                 310                 315                 320 


Arg Gly Ala Pro Leu Leu Ala Arg Xaa Lys Asn Gly Leu Ser Pro Leu 
                325                 330                 335     


His Met Ala Ala Gln Gly Asp His Val Glu Cys Val Lys His Leu Leu 
            340                 345                 350         


Gln His Lys Ala Pro Val Asp Asp Val Xaa Leu Asp Tyr Leu Xaa Ala 
        355                 360                 365             


Leu His Val Ala Ala His Cys Gly His Tyr Arg Val Xaa Lys Leu Leu 
    370                 375                 380                 


Leu Asp Lys Arg Ala Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Xaa 
385                 390                 395                 400 


Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu 
                405                 410                 415     


Leu Val Lys Tyr Gly Ala Ser Ile Gln Ala Ile Xaa Glu Ser Gly Leu 
            420                 425                 430         


Xaa Pro Ile His Val Ala Ala Phe Met Gly His Leu Asn Ile Val Leu 
        435                 440                 445             


Leu Leu Leu Gln Asn Gly Ala Ser Pro Asp Val Xaa Asn Ile Arg Gly 
    450                 455                 460                 


Glu Xaa Ala Leu His Met Ala Ala Arg Ala Gly Gln Val Glu Val Val 
465                 470                 475                 480 


Arg Cys Leu Leu Arg Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu 
                485                 490                 495     


Glu Gln Xaa Pro Leu His Ile Ala Ser Arg Leu Gly Lys Xaa Glu Ile 
            500                 505                 510         


Val Gln Leu Leu Leu Gln His Met Ala His Pro Asp Ala Ala Xaa Xaa 
        515                 520                 525             


Asn Gly Tyr Xaa Pro Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp 
    530                 535                 540                 


Val Ala Ser Val Leu Leu Glu Ala Gly Ala Ala His Ser Leu Ala Xaa 
545                 550                 555                 560 


Lys Lys Gly Phe Xaa Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu 
                565                 570                 575     


Asp Val Ala Lys Leu Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala 
            580                 585                 590         


Gly Lys Asn Gly Leu Xaa Pro Leu His Val Ala Ala His Tyr Asp Asn 
        595                 600                 605             


Gln Lys Val Ala Leu Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala 
    610                 615                 620                 


Xaa Ala Lys Asn Gly Tyr Xaa Pro Leu His Ile Ala Ala Lys Lys Asn 
625                 630                 635                 640 


Gln Met Gln Ile Ala Ser Xaa Leu Leu Asn Tyr Gly Ala Glu Xaa Asn 
                645                 650                 655     


Ile Val Xaa Lys Gln Gly Val Xaa Pro Leu His Leu Ala Ser Gln Glu 
            660                 665                 670         


Gly His Xaa Asp Met Val Xaa Leu Leu Leu Asp Lys Gly Ala Asn Ile 
        675                 680                 685             


His Met Ser Xaa Lys Ser Gly Leu Xaa Ser Leu His Leu Ala Ala Gln 
    690                 695                 700                 


Glu Asp Lys Val Asn Val Ala Asp Ile Leu Xaa Lys His Gly Ala Asp 
705                 710                 715                 720 


Gln Asp Ala His Xaa Lys Leu Gly Tyr Xaa Pro Leu Ile Val Ala Cys 
                725                 730                 735     


His Tyr Gly Asn Val Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala 
            740                 745                 750         


Asn Val Asn Ala Lys Xaa Lys Asn Gly Tyr Xaa Pro Leu His Gln Ala 
        755                 760                 765             


Ala Gln Gln Gly His Xaa His Ile Ile Asn Val Leu Leu Gln His Gly 
    770                 775                 780                 


Ala Lys Pro Asn Ala Xaa Xaa Ala Asn Gly Asn Xaa Ala Leu Ala Ile 
785                 790                 795                 800 


Ala Lys Arg Leu Gly Tyr Ile Ser Val Val Asp Xaa Leu Lys Val Val 
                805                 810                 815     


Xaa Glu Glu Val Xaa Xaa Xaa Xaa Xaa Xaa Ile Xaa Glu Lys His Lys 
            820                 825                 830         


Leu Asn Val Pro Glu Xaa Met Xaa Glu Val Leu Asp Val Ser Asp Glu 
        835                 840                 845             


Glu Gly Asp Asp Xaa Met Xaa Gly Asp Gly Gly Glu Tyr Leu Arg Pro 
    850                 855                 860                 


Glu Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe 
865                 870                 875                 880 


Leu Asp Gly Met Asn Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser 
                885                 890                 895     


Asp Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser His Xaa Leu Ser His 
            900                 905                 910         


Ala Ser Tyr Leu Arg Asp Ser Ala Val Met Asp Asp Ser Val Val Ile 
        915                 920                 925             


Pro Ser His Gln Val Ser Xaa Leu Ala Lys Glu Ala Glu Arg Asn Ser 
    930                 935                 940                 


Tyr Arg Leu Ser Trp Gly Xaa Glu Asn Leu Asp Asn Val Ala Leu Ser 
945                 950                 955                 960 


Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala 
                965                 970                 975     


Arg Gly Gly Ala Met Arg Gly Cys Arg His Asn Gly Leu Arg Ile Ile 
            980                 985                 990         


Ile Pro Pro Arg Lys Cys Xaa Ala  Pro Xaa Arg Val Xaa  Cys Arg Leu 
        995                 1000                 1005             


Val Lys  Arg His Arg Leu Ala  Xaa Met Pro Pro Met  Val Glu Gly 
    1010                 1015                 1020             


Glu Gly  Leu Ala Ser Arg Leu  Ile Glu Val Gly Pro  Ser Gly Ala 
    1025                 1030                 1035             


Gln Phe  Leu Gly Lys Leu His  Leu Pro Xaa Ala Pro  Pro Pro Leu 
    1040                 1045                 1050             


Asn Glu  Gly Glu Ser Leu Val  Ser Arg Ile Leu Gln  Leu Gly Pro 
    1055                 1060                 1065             


Pro Gly  Xaa Lys Phe Leu Gly  Pro Val Ile Val Glu  Ile Pro His 
    1070                 1075                 1080             


Phe Ala  Ala Leu Arg Gly Lys  Glu Arg Glu Leu Val  Val Leu Arg 
    1085                 1090                 1095             


Ser Glu  Asn Gly Asp Ser Trp  Lys Glu His Phe Cys  Asp Tyr Xaa 
    1100                 1105                 1110             


Glu Asp  Glu Leu Asn Glu Ile  Leu Asn Gly Met Asp  Glu Val Leu 
    1115                 1120                 1125             


Asp Ser  Pro Glu Asp Leu Glu  Lys Lys Arg Ile Cys  Arg Ile Ile 
    1130                 1135                 1140             


Xaa Arg  Asp Phe Pro Gln Tyr  Phe Ala Val Val Ser  Arg Ile Lys 
    1145                 1150                 1155             


Gln Asp  Ser Asn Leu Ile Gly  Pro Glu Gly Gly Val  Leu Ser Ser 
    1160                 1165                 1170             


Xaa Val  Val Pro Gln Val Gln  Ala Val Phe Pro Glu  Gly Ala Leu 
    1175                 1180                 1185             


Xaa Lys  Arg Ile Arg Val Gly  Leu Gln Ala Gln Pro  Met His Ser 
    1190                 1195                 1200             


Glu Leu  Val Lys Lys Ile Leu  Gly Asn Lys Ala Xaa  Phe Ser Pro 
    1205                 1210                 1215             


Ile Val  Xaa Leu Glu Pro Arg  Arg Arg Lys Phe His  Lys Pro Ile 
    1220                 1225                 1230             


Xaa Met  Xaa Ile Pro Val Pro  Lys Ala Ser Ser Asp  Val Met Leu 
    1235                 1240                 1245             


Asn Gly  Phe Gly Gly Asp Ala  Pro Xaa Leu Arg Leu  Leu Cys Ser 
    1250                 1255                 1260             


Ile Xaa  Gly Gly Xaa Xaa Pro  Ala Gln Trp Glu Asp  Ile Xaa Gly 
    1265                 1270                 1275             


Xaa Xaa  Pro Leu Xaa Phe Val  Asn Glu Cys Val Ser  Phe Xaa Xaa 
    1280                 1285                 1290             


Asn Val  Ser Ala Arg Phe Trp  Leu Ile Asp Cys Arg  Gln Ile Gln 
    1295                 1300                 1305             


Glu Ser  Val Xaa Phe Ala Ser  Gln Val Tyr Arg Glu  Ile Ile Cys 
    1310                 1315                 1320             


Val Pro  Tyr Met Ala Lys Phe  Val Val Phe Ala Lys  Ser His Asp 
    1325                 1330                 1335             


Pro Ile  Glu Ala Arg Leu Arg  Cys Phe Cys Met Xaa  Asp Asp Lys 
    1340                 1345                 1350             


Val Asp  Lys Xaa Leu Glu Gln  Gln Glu Asn Phe Ala  Glu Val Ala 
    1355                 1360                 1365             


Arg Ser  Arg Asp Val Glu Val  Leu Glu Gly Lys Pro  Ile Tyr Val 
    1370                 1375                 1380             


Asp Cys  Phe Gly Asn Leu Val  Pro Leu Xaa Lys Ser  Gly Gln His 
    1385                 1390                 1395             


His Ile  Phe Ser Phe Phe Ala  Phe Lys Glu Asn Arg  Leu Pro Leu 
    1400                 1405                 1410             


Phe Val  Lys Val Arg Asp Xaa  Xaa Gln Glu Pro Cys  Gly Arg Leu 
    1415                 1420                 1425             


Ser Phe  Met Lys Glu Pro Lys  Ser Xaa Arg Gly Leu  Val His Gln 
    1430                 1435                 1440             


Ala Ile  Cys Asn Leu Asn Ile  Xaa Leu Pro Ile Tyr  Xaa Lys Glu 
    1445                 1450                 1455             


Ser Glu  Ser Asp Gln Glu Gln  Glu Glu Glu Ile Asp  Met Xaa Ser 
    1460                 1465                 1470             


Glu Lys  Asn Pro Gln Asp Glu  Gln Glu Arg Ile Glu  Glu Arg Leu 
    1475                 1480                 1485             


Ala Tyr  Ile Ala Asp His Leu  Gly Phe Ser Trp Xaa  Glu Leu Ala 
    1490                 1495                 1500             


Arg Glu  Leu Asp Phe Xaa Glu  Glu Gln Ile His Gln  Ile Arg Ile 
    1505                 1510                 1515             


Glu Asn  Pro Asn Ser Leu Gln  Asp Gln Ser His Ala  Leu Leu Lys 
    1520                 1525                 1530             


Tyr Trp  Leu Glu Arg Asp Gly  Lys His Ala Xaa Asp  Xaa Asn Leu 
    1535                 1540                 1545             


Val Glu  Cys Leu Xaa Lys Ile  Asn Arg Met Asp Ile  Val His Leu 
    1550                 1555                 1560             


Met Glu  Xaa Asn Xaa Glu Pro  Leu Gln Glu Arg Ile  Ser His Ser 
    1565                 1570                 1575             


Tyr Ala  Glu Ile Glu Gln Xaa  Ile Xaa Leu Asp His  Ser Glu Gly 
    1580                 1585                 1590             


Phe Ser  Val Leu Gln Glu Glu  Leu Cys Xaa Ala Gln  His Lys Gln 
    1595                 1600                 1605             


Lys Glu  Glu Gln Ala Val Ser  Lys Glu Ser Glu Xaa  Cys Asp His 
    1610                 1615                 1620             


Pro Pro  Ile Val Ser Glu Glu  Asp Ile Ser Val Gly  Tyr Ser Xaa 
    1625                 1630                 1635             


Phe Gln  Asp Gly Val Pro Lys  Xaa Glu Gly Asp Ser  Ser Ala Xaa 
    1640                 1645                 1650             


Ala Leu  Phe Pro Gln Xaa His  Lys Glu Gln Val Gln  Gln Asp Phe 
    1655                 1660                 1665             


Ser Gly  Lys Met Gln Asp Leu  Pro Glu Glu Ser Ser  Leu Glu Tyr 
    1670                 1675                 1680             


Gln Gln  Glu Tyr Phe Val Xaa  Xaa Pro Gly Xaa Glu  Xaa Ser Glu 
    1685                 1690                 1695             


Xaa Gln  Lys Ala Met Ile Val  Pro Ser Ser Pro Ser  Lys Xaa Pro 
    1700                 1705                 1710             


Glu Glu  Val Ser Xaa Pro Ala  Glu Glu Glu Lys Leu  Tyr Leu Gln 
    1715                 1720                 1725             


Xaa Pro  Xaa Ser Ser Glu Arg  Gly Gly Ser Pro Ile  Ile Gln Glu 
    1730                 1735                 1740             


Pro Glu  Glu Pro Ser Glu His  Arg Glu Glu Ser Ser  Pro Arg Lys 
    1745                 1750                 1755             


Xaa Ser  Leu Val Ile Val Glu  Ser Ala Asp Asn Gln  Pro Glu Xaa 
    1760                 1765                 1770             


Cys Glu  Arg Leu Asp Glu Asp  Ala Ala Phe Glu Lys  Gly Asp Asp 
    1775                 1780                 1785             


Met Pro  Glu Ile Pro Pro Glu  Xaa Val Xaa Glu Glu  Glu Tyr Ile 
    1790                 1795                 1800             


Asp Glu  His Gly His Xaa Val  Val Lys Lys Val Xaa  Arg Lys Ile 
    1805                 1810                 1815             


Ile Arg  Arg Tyr Val Ser Ser  Glu Gly Xaa Glu Lys  Glu Glu Ile 
    1820                 1825                 1830             


Met Val  Gln Gly Met Pro Gln  Glu Pro Val Asn Ile  Glu Glu Gly 
    1835                 1840                 1845             


Asp Gly  Tyr Ser Lys Val Ile  Lys Arg Val Val Leu  Lys Ser Asp 
    1850                 1855                 1860             


Xaa Glu  Gln Ser Glu Asp Asn  Asn Glu 
    1865                 1870         


<210> 2301
<211> 3924
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1224)..(1224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1235)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1244)..(1244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1246)..(1247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1317)..(1317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1324)..(1324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1360)..(1360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1387)..(1388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1418)..(1418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1439)..(1439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1449)..(1449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1451)..(1451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1485)..(1485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1489)..(1490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1537)..(1537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1539)..(1539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1579)..(1579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1601)..(1601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1608)..(1608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1613)..(1613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1624)..(1624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1654)..(1654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1717)..(1717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1728)..(1728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1768)..(1769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1794)..(1794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1799)..(1799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1806)..(1806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1818)..(1818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1830)..(1830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1842)..(1842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1852)..(1852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1854)..(1854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1863)..(1863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1865)..(1865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1877)..(1877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1889)..(1889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1900)..(1900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1912)..(1912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1920)..(1920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1924)..(1924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1936)..(1936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1945)..(1945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1948)..(1948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1954)..(1954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1975)..(1975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2005)..(2005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2012)..(2012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2016)..(2016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2026)..(2026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2028)..(2028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2099)..(2099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2101)..(2101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2126)..(2126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2138)..(2138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2143)..(2144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2189)..(2189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2206)..(2206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2209)..(2209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2225)..(2225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2228)..(2228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2232)..(2232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2234)..(2234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2236)..(2238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2248)..(2249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2253)..(2253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2262)..(2262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2264)..(2264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2269)..(2269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2271)..(2271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2279)..(2279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2286)..(2286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2295)..(2295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2306)..(2306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2308)..(2308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2311)..(2311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2322)..(2322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2330)..(2330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2332)..(2332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2340)..(2340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2342)..(2342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2346)..(2346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2358)..(2358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2360)..(2360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2362)..(2362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2418)..(2418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2463)..(2463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2467)..(2467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2492)..(2492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2507)..(2507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2518)..(2518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2521)..(2522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2526)..(2526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2550)..(2550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2560)..(2560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2607)..(2607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2621)..(2621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2686)..(2686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2693)..(2693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2719)..(2719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2733)..(2733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2764)..(2764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2784)..(2784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2789)..(2789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2835)..(2835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2841)..(2841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2844)..(2844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2846)..(2846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2849)..(2849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2865)..(2866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2868)..(2868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2892)..(2892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2911)..(2911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2913)..(2913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2918)..(2919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2930)..(2930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2932)..(2932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2947)..(2947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2969)..(2969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2985)..(2985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2989)..(2991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3003)..(3003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3005)..(3005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3045)..(3046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3049)..(3050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3054)..(3054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3056)..(3056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3060)..(3060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3062)..(3062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3079)..(3079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3087)..(3087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3109)..(3109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3119)..(3119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3128)..(3128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3141)..(3141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3177)..(3177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3179)..(3179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3181)..(3181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3189)..(3189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3194)..(3194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3197)..(3197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3227)..(3227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3229)..(3229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3256)..(3256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3265)..(3265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3275)..(3275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3278)..(3278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3280)..(3280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3333)..(3333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3338)..(3338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3368)..(3368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3374)..(3374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3378)..(3378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3380)..(3380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3382)..(3382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3400)..(3400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3406)..(3406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3416)..(3417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3424)..(3424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3427)..(3427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3460)..(3460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3491)..(3491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3502)..(3502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3512)..(3512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3552)..(3552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3561)..(3561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3596)..(3596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3598)..(3598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3605)..(3605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3618)..(3618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3620)..(3620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3637)..(3637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3639)..(3639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3655)..(3655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3672)..(3672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3690)..(3690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3698)..(3698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3705)..(3705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3711)..(3711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3742)..(3743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3746)..(3746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3748)..(3748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3751)..(3751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3764)..(3764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3770)..(3770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3781)..(3781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3783)..(3783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3811)..(3811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3825)..(3825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3848)..(3848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3850)..(3850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3861)..(3861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3867)..(3867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3880)..(3880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3916)..(3916)
<223> Selenocysteine

<400> 2301
Met Met Asn Glu Asp Ala Ala Gln Lys Ser Asp Ser Gly Glu Lys Phe 
1               5                   10                  15      


Asn Gly Ser Ser Gln Arg Arg Lys Arg Pro Lys Lys Ser Asp Ser Asn 
            20                  25                  30          


Ala Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val 
        35                  40                  45              


Glu Tyr Leu Lys Gly Gly Ile Asp Ile Asn Xaa Cys Asn Gln Asn Gly 
    50                  55                  60                  


Leu Asn Ala Leu His Leu Ala Ala Lys Glu Gly His Val Gly Leu Val 
65                  70                  75                  80  


Gln Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser Ala Xaa Lys Lys 
                85                  90                  95      


Gly Asn Xaa Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val 
            100                 105                 110         


Val Lys Val Leu Val Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln 
        115                 120                 125             


Asn Gly Phe Xaa Pro Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp 
    130                 135                 140                 


Val Val Lys Tyr Leu Leu Glu Asn Gly Ala Asn Gln Ser Xaa Ala Xaa 
145                 150                 155                 160 


Glu Asp Gly Phe Xaa Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn 
                165                 170                 175     


Gln Ala Val Ala Ile Leu Leu Glu Asn Asp Xaa Lys Gly Lys Val Arg 
            180                 185                 190         


Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp Xaa Lys Ser Ala 
        195                 200                 205             


Ala Leu Leu Leu Gln Asn Asp His Asn Ala Asp Val Gln Ser Lys Met 
    210                 215                 220                 


Met Val Asn Arg Xaa Xaa Glu Ser Gly Phe Xaa Pro Leu His Ile Ala 
225                 230                 235                 240 


Ala His Tyr Gly Asn Val Asn Val Ala Xaa Leu Leu Leu Asn Arg Gly 
                245                 250                 255     


Ala Ala Val Asp Phe Xaa Ala Arg Asn Gly Ile Xaa Pro Leu His Val 
            260                 265                 270         


Ala Ser Lys Arg Gly Asn Xaa Asn Met Val Lys Leu Leu Leu Asp Arg 
        275                 280                 285             


Gly Gly Gln Ile Asp Ala Lys Xaa Arg Asp Gly Leu Xaa Pro Leu His 
    290                 295                 300                 


Cys Ala Ala Arg Ser Gly His Asp Gln Val Val Glu Leu Leu Leu Glu 
305                 310                 315                 320 


Arg Gly Ala Pro Leu Leu Ala Arg Xaa Lys Asn Gly Leu Ser Pro Leu 
                325                 330                 335     


His Met Ala Ala Gln Gly Asp His Val Glu Cys Val Lys His Leu Leu 
            340                 345                 350         


Gln His Lys Ala Pro Val Asp Asp Val Xaa Leu Asp Tyr Leu Xaa Ala 
        355                 360                 365             


Leu His Val Ala Ala His Cys Gly His Tyr Arg Val Xaa Lys Leu Leu 
    370                 375                 380                 


Leu Asp Lys Arg Ala Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Xaa 
385                 390                 395                 400 


Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu 
                405                 410                 415     


Leu Val Lys Tyr Gly Ala Ser Ile Gln Ala Ile Xaa Glu Ser Gly Leu 
            420                 425                 430         


Xaa Pro Ile His Val Ala Ala Phe Met Gly His Leu Asn Ile Val Leu 
        435                 440                 445             


Leu Leu Leu Gln Asn Gly Ala Ser Pro Asp Val Xaa Asn Ile Arg Gly 
    450                 455                 460                 


Glu Xaa Ala Leu His Met Ala Ala Arg Ala Gly Gln Val Glu Val Val 
465                 470                 475                 480 


Arg Cys Leu Leu Arg Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu 
                485                 490                 495     


Glu Gln Xaa Pro Leu His Ile Ala Ser Arg Leu Gly Lys Xaa Glu Ile 
            500                 505                 510         


Val Gln Leu Leu Leu Gln His Met Ala His Pro Asp Ala Ala Xaa Xaa 
        515                 520                 525             


Asn Gly Tyr Xaa Pro Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp 
    530                 535                 540                 


Val Ala Ser Val Leu Leu Glu Ala Gly Ala Ala His Ser Leu Ala Xaa 
545                 550                 555                 560 


Lys Lys Gly Phe Xaa Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu 
                565                 570                 575     


Asp Val Ala Lys Leu Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala 
            580                 585                 590         


Gly Lys Asn Gly Leu Xaa Pro Leu His Val Ala Ala His Tyr Asp Asn 
        595                 600                 605             


Gln Lys Val Ala Leu Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala 
    610                 615                 620                 


Xaa Ala Lys Asn Gly Tyr Xaa Pro Leu His Ile Ala Ala Lys Lys Asn 
625                 630                 635                 640 


Gln Met Gln Ile Ala Ser Xaa Leu Leu Asn Tyr Gly Ala Glu Xaa Asn 
                645                 650                 655     


Ile Val Xaa Lys Gln Gly Val Xaa Pro Leu His Leu Ala Ser Gln Glu 
            660                 665                 670         


Gly His Xaa Asp Met Val Xaa Leu Leu Leu Asp Lys Gly Ala Asn Ile 
        675                 680                 685             


His Met Ser Xaa Lys Ser Gly Leu Xaa Ser Leu His Leu Ala Ala Gln 
    690                 695                 700                 


Glu Asp Lys Val Asn Val Ala Asp Ile Leu Xaa Lys His Gly Ala Asp 
705                 710                 715                 720 


Gln Asp Ala His Xaa Lys Leu Gly Tyr Xaa Pro Leu Ile Val Ala Cys 
                725                 730                 735     


His Tyr Gly Asn Val Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala 
            740                 745                 750         


Asn Val Asn Ala Lys Xaa Lys Asn Gly Tyr Xaa Pro Leu His Gln Ala 
        755                 760                 765             


Ala Gln Gln Gly His Xaa His Ile Ile Asn Val Leu Leu Gln His Gly 
    770                 775                 780                 


Ala Lys Pro Asn Ala Xaa Xaa Ala Asn Gly Asn Xaa Ala Leu Ala Ile 
785                 790                 795                 800 


Ala Lys Arg Leu Gly Tyr Ile Ser Val Val Asp Xaa Leu Lys Val Val 
                805                 810                 815     


Xaa Glu Glu Val Xaa Xaa Xaa Xaa Xaa Xaa Ile Xaa Glu Lys His Lys 
            820                 825                 830         


Leu Asn Val Pro Glu Xaa Met Xaa Glu Val Leu Asp Val Ser Asp Glu 
        835                 840                 845             


Glu Gly Asp Asp Xaa Met Xaa Gly Asp Gly Gly Glu Tyr Leu Arg Pro 
    850                 855                 860                 


Glu Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe 
865                 870                 875                 880 


Leu Asp Gly Met Asn Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser 
                885                 890                 895     


Asp Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser His Xaa Leu Ser His 
            900                 905                 910         


Ala Ser Tyr Leu Arg Asp Ser Ala Val Met Asp Asp Ser Val Val Ile 
        915                 920                 925             


Pro Ser His Gln Val Ser Xaa Leu Ala Lys Glu Ala Glu Arg Asn Ser 
    930                 935                 940                 


Tyr Arg Leu Ser Trp Gly Xaa Glu Asn Leu Asp Asn Val Ala Leu Ser 
945                 950                 955                 960 


Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala 
                965                 970                 975     


Arg Gly Gly Ala Met Arg Gly Cys Arg His Asn Gly Leu Arg Ile Ile 
            980                 985                 990         


Ile Pro Pro Arg Lys Cys Xaa Ala  Pro Xaa Arg Val Xaa  Cys Arg Leu 
        995                 1000                 1005             


Val Lys  Arg His Arg Leu Ala  Xaa Met Pro Pro Met  Val Glu Gly 
    1010                 1015                 1020             


Glu Gly  Leu Ala Ser Arg Leu  Ile Glu Val Gly Pro  Ser Gly Ala 
    1025                 1030                 1035             


Gln Phe  Leu Gly Pro Val Ile  Val Glu Ile Pro His  Phe Ala Ala 
    1040                 1045                 1050             


Leu Arg  Gly Lys Glu Arg Glu  Leu Val Val Leu Arg  Ser Glu Asn 
    1055                 1060                 1065             


Gly Asp  Ser Trp Lys Glu His  Phe Cys Asp Tyr Xaa  Glu Asp Glu 
    1070                 1075                 1080             


Leu Asn  Glu Ile Leu Asn Gly  Met Asp Glu Val Leu  Asp Ser Pro 
    1085                 1090                 1095             


Glu Asp  Leu Glu Lys Lys Arg  Ile Cys Arg Ile Ile  Xaa Arg Asp 
    1100                 1105                 1110             


Phe Pro  Gln Tyr Phe Ala Val  Val Ser Arg Ile Lys  Gln Asp Ser 
    1115                 1120                 1125             


Asn Leu  Ile Gly Pro Glu Gly  Gly Val Leu Ser Ser  Xaa Val Val 
    1130                 1135                 1140             


Pro Gln  Val Gln Ala Val Phe  Pro Glu Gly Ala Leu  Xaa Lys Arg 
    1145                 1150                 1155             


Ile Arg  Val Gly Leu Gln Ala  Gln Pro Met His Ser  Glu Leu Val 
    1160                 1165                 1170             


Lys Lys  Ile Leu Gly Asn Lys  Ala Xaa Phe Ser Pro  Ile Val Xaa 
    1175                 1180                 1185             


Leu Glu  Pro Arg Arg Arg Lys  Phe His Lys Pro Ile  Xaa Met Xaa 
    1190                 1195                 1200             


Ile Pro  Val Pro Lys Ala Ser  Ser Asp Val Met Leu  Asn Gly Phe 
    1205                 1210                 1215             


Gly Gly  Asp Ala Pro Xaa Leu  Arg Leu Leu Cys Ser  Ile Xaa Gly 
    1220                 1225                 1230             


Gly Xaa  Xaa Pro Ala Gln Trp  Glu Asp Ile Xaa Gly  Xaa Xaa Pro 
    1235                 1240                 1245             


Leu Xaa  Phe Val Asn Glu Cys  Val Ser Phe Xaa Xaa  Asn Val Ser 
    1250                 1255                 1260             


Ala Arg  Phe Trp Leu Ile Asp  Cys Arg Gln Ile Gln  Glu Ser Val 
    1265                 1270                 1275             


Xaa Phe  Ala Ser Gln Val Tyr  Arg Glu Ile Ile Cys  Val Pro Tyr 
    1280                 1285                 1290             


Met Ala  Lys Phe Val Val Phe  Ala Lys Ser His Asp  Pro Ile Glu 
    1295                 1300                 1305             


Ala Arg  Leu Arg Cys Phe Cys  Met Xaa Asp Asp Lys  Val Asp Lys 
    1310                 1315                 1320             


Xaa Leu  Glu Gln Gln Glu Asn  Phe Ala Glu Val Ala  Arg Ser Arg 
    1325                 1330                 1335             


Asp Val  Glu Val Leu Glu Gly  Lys Pro Ile Tyr Val  Asp Cys Phe 
    1340                 1345                 1350             


Gly Asn  Leu Val Pro Leu Xaa  Lys Ser Gly Gln His  His Ile Phe 
    1355                 1360                 1365             


Ser Phe  Phe Ala Phe Lys Glu  Asn Arg Leu Pro Leu  Phe Val Lys 
    1370                 1375                 1380             


Val Arg  Asp Xaa Xaa Gln Glu  Pro Cys Gly Arg Leu  Ser Phe Met 
    1385                 1390                 1395             


Lys Glu  Pro Lys Ser Xaa Arg  Gly Leu Val His Gln  Ala Ile Cys 
    1400                 1405                 1410             


Asn Leu  Asn Ile Xaa Leu Pro  Ile Tyr Xaa Lys Glu  Ser Glu Ser 
    1415                 1420                 1425             


Asp Gln  Glu Gln Glu Glu Glu  Ile Asp Met Xaa Ser  Glu Lys Asn 
    1430                 1435                 1440             


Asp Glu  Xaa Glu Ser Xaa Glu  Xaa Ser Val Leu Lys  Ser His Leu 
    1445                 1450                 1455             


Val Asn  Glu Val Pro Val Leu  Ala Ser Pro Asp Leu  Leu Ser Glu 
    1460                 1465                 1470             


Val Ser  Glu Met Lys Gln Asp  Leu Ile Lys Met Xaa  Ala Ile Leu 
    1475                 1480                 1485             


Xaa Xaa  Asp Val Ser Asp Lys  Ala Gly Ser Ile Lys  Val Lys Glu 
    1490                 1495                 1500             


Leu Val  Lys Ala Ala Glu Glu  Glu Pro Gly Glu Pro  Phe Glu Ile 
    1505                 1510                 1515             


Val Glu  Arg Val Lys Glu Asp  Leu Glu Lys Val Asn  Glu Ile Leu 
    1520                 1525                 1530             


Arg Ser  Gly Xaa Cys Xaa Arg  Asp Glu Ser Ser Val  Gln Ser Ser 
    1535                 1540                 1545             


Arg Ser  Glu Arg Gly Leu Val  Glu Glu Glu Trp Val  Ile Val Ser 
    1550                 1555                 1560             


Asp Glu  Glu Ile Glu Glu Ala  Arg Gln Lys Ala Pro  Leu Glu Ile 
    1565                 1570                 1575             


Xaa Glu  Tyr Pro Cys Val Glu  Val Arg Ile Asp Lys  Glu Ile Lys 
    1580                 1585                 1590             


Gly Lys  Val Glu Lys Asp Ser  Xaa Gly Leu Val Asn  Tyr Leu Xaa 
    1595                 1600                 1605             


Asp Asp  Leu Asn Xaa Cys Val  Pro Leu Pro Lys Glu  Gln Leu Gln 
    1610                 1615                 1620             


Xaa Val  Gln Asp Lys Ala Gly  Lys Lys Cys Glu Ala  Leu Ala Val 
    1625                 1630                 1635             


Gly Arg  Ser Ser Glu Lys Glu  Gly Lys Asp Ile Pro  Pro Asp Glu 
    1640                 1645                 1650             


Xaa Gln  Ser Xaa Gln Lys Gln  His Lys Pro Ser Leu  Gly Ile Lys 
    1655                 1660                 1665             


Lys Pro  Val Arg Arg Lys Leu  Lys Glu Lys Gln Lys  Gln Lys Glu 
    1670                 1675                 1680             


Glu Gly  Leu Gln Ala Ser Ala  Glu Lys Ala Glu Leu  Lys Lys Gly 
    1685                 1690                 1695             


Ser Ser  Glu Glu Ser Leu Gly  Glu Asp Pro Gly Leu  Ala Pro Glu 
    1700                 1705                 1710             


Pro Leu  Pro Xaa Val Lys Ala  Xaa Ser Pro Leu Ile  Glu Glu Xaa 
    1715                 1720                 1725             


Pro Ile  Gly Ser Ile Lys Asp  Lys Val Lys Ala Leu  Gln Lys Arg 
    1730                 1735                 1740             


Val Glu  Asp Glu Gln Lys Gly  Arg Ser Lys Leu Pro  Ile Arg Val 
    1745                 1750                 1755             


Lys Gly  Lys Glu Asp Val Pro  Lys Lys Xaa Xaa His  Arg Pro His 
    1760                 1765                 1770             


Pro Ala  Ala Ser Pro Ser Leu  Lys Ser Glu Arg His  Ala Pro Gly 
    1775                 1780                 1785             


Ser Pro  Ser Pro Lys Xaa Glu  Arg His Ser Xaa Leu  Ser Ser Ser 
    1790                 1795                 1800             


Ala Lys  Xaa Glu Arg His Pro  Pro Val Ser Pro Ser  Ser Lys Xaa 
    1805                 1810                 1815             


Glu Lys  His Ser Pro Val Ser  Pro Ser Ala Lys Xaa  Glu Arg His 
    1820                 1825                 1830             


Ser Pro  Ala Ser Ser Ser Ser  Lys Xaa Glu Lys His  Ser Pro Val 
    1835                 1840                 1845             


Ser Pro  Ser Xaa Lys Xaa Glu  Arg His Ser Pro Val  Ser Ser Xaa 
    1850                 1855                 1860             


Lys Xaa  Glu Arg His Pro Pro  Val Ser Pro Ser Gly  Lys Xaa Asp 
    1865                 1870                 1875             


Lys Arg  Pro Pro Val Ser Pro  Ser Gly Arg Xaa Glu  Lys His Pro 
    1880                 1885                 1890             


Pro Val  Ser Pro Gly Arg Xaa  Glu Lys Arg Leu Pro  Val Ser Pro 
    1895                 1900                 1905             


Ser Gly  Arg Xaa Asp Lys His  Gln Pro Val Ser Xaa  Ala Gly Lys 
    1910                 1915                 1920             


Xaa Glu  Lys His Leu Pro Val  Ser Pro Ser Gly Lys  Xaa Glu Lys 
    1925                 1930                 1935             


Gln Pro  Pro Val Ser Pro Xaa  Ser Lys Xaa Glu Arg  Ile Glu Glu 
    1940                 1945                 1950             


Xaa Met  Ser Val Arg Glu Leu  Met Lys Ala Phe Gln  Ser Gly Gln 
    1955                 1960                 1965             


Asp Pro  Ser Lys His Lys Xaa  Gly Leu Phe Glu His  Lys Ser Ala 
    1970                 1975                 1980             


Lys Gln  Lys Gln Pro Gln Glu  Lys Gly Lys Val Arg  Val Glu Lys 
    1985                 1990                 1995             


Glu Lys  Gly Pro Ile Leu Xaa  Gln Arg Glu Ala Gln  Lys Xaa Glu 
    2000                 2005                 2010             


Asn Gln  Xaa Ile Lys Arg Gly  Gln Arg Leu Pro Val  Xaa Gly Xaa 
    2015                 2020                 2025             


Ala Glu  Ser Lys Arg Gly Val  Arg Val Ser Ser Ile  Gly Val Lys 
    2030                 2035                 2040             


Lys Glu  Asp Ala Ala Gly Gly  Lys Glu Lys Val Leu  Ser His Lys 
    2045                 2050                 2055             


Ile Pro  Glu Pro Val Gln Ser  Val Pro Glu Glu Glu  Ser His Arg 
    2060                 2065                 2070             


Glu Ser  Glu Val Pro Lys Glu  Lys Met Ala Asp Glu  Gln Gly Asp 
    2075                 2080                 2085             


Met Asp  Leu Gln Ile Ser Pro  Asp Arg Lys Xaa Ser  Xaa Asp Phe 
    2090                 2095                 2100             


Ser Glu  Val Ile Lys Gln Glu  Leu Glu Asp Asn Asp  Lys Tyr Gln 
    2105                 2110                 2115             


Gln Phe  Arg Leu Ser Glu Glu  Xaa Glu Lys Ala Gln  Leu His Leu 
    2120                 2125                 2130             


Asp Gln  Val Leu Xaa Ser Pro  Phe Asn Xaa Xaa Phe  Pro Leu Asp 
    2135                 2140                 2145             


Tyr Met  Lys Asp Glu Phe Leu  Pro Ala Leu Ser Leu  Gln Ser Gly 
    2150                 2155                 2160             


Ala Leu  Asp Gly Ser Ser Glu  Ser Leu Lys Asn Glu  Gly Val Ala 
    2165                 2170                 2175             


Gly Ser  Pro Cys Gly Ser Leu  Met Glu Gly Xaa Pro  Gln Ile Ser 
    2180                 2185                 2190             


Ser Glu  Glu Ser Tyr Lys His  Glu Gly Leu Ala Glu  Xaa Pro Glu 
    2195                 2200                 2205             


Xaa Ser  Pro Glu Ser Leu Ser  Phe Ser Pro Lys Lys  Ser Glu Glu 
    2210                 2215                 2220             


Gln Xaa  Gly Glu Xaa Lys Glu  Ser Xaa Lys Xaa Glu  Xaa Xaa Xaa 
    2225                 2230                 2235             


Glu Ile  Arg Ser Glu Lys Glu  His Pro Xaa Xaa Lys  Asp Ile Xaa 
    2240                 2245                 2250             


Gly Gly  Ser Glu Glu Arg Gly  Ala Xaa Val Xaa Glu  Asp Ser Glu 
    2255                 2260                 2265             


Xaa Ser  Xaa Glu Ser Phe Gln  Lys Glu Ala Xaa Leu  Gly Ser Pro 
    2270                 2275                 2280             


Lys Asp  Xaa Ser Pro Lys Arg  Gln Asp Asp Cys Xaa  Gly Ser Cys 
    2285                 2290                 2295             


Ser Val  Ala Leu Ala Lys Glu  Xaa Pro Xaa Gly Leu  Xaa Glu Glu 
    2300                 2305                 2310             


Ala Ala  Cys Asp Glu Gly Gln  Arg Xaa Phe Gly Ser  Ser Ala His 
    2315                 2320                 2325             


Lys Xaa  Gln Xaa Asp Ser Glu  Val Gln Glu Ser Xaa  Ala Xaa Ser 
    2330                 2335                 2340             


Asp Glu  Xaa Lys Ala Leu Pro  Leu Pro Glu Ala Ser  Val Lys Xaa 
    2345                 2350                 2355             


Asp Xaa  Gly Xaa Glu Ser Lys  Pro Gln Gly Val Ile  Arg Ser Pro 
    2360                 2365                 2370             


Gln Gly  Leu Glu Leu Ala Leu  Pro Ser Arg Asp Ser  Glu Val Leu 
    2375                 2380                 2385             


Ser Ala  Val Ala Asp Asp Ser  Leu Ala Val Ser His  Lys Asp Ser 
    2390                 2395                 2400             


Leu Glu  Ala Ser Pro Val Leu  Glu Asp Asn Ser Ser  His Lys Xaa 
    2405                 2410                 2415             


Pro Asp  Ser Leu Glu Pro Ser  Pro Leu Lys Glu Ser  Pro Cys Arg 
    2420                 2425                 2430             


Asp Ser  Leu Glu Ser Ser Pro  Val Glu Pro Lys Met  Lys Ala Gly 
    2435                 2440                 2445             


Ile Phe  Pro Ser His Phe Pro  Leu Pro Ala Ala Val  Ala Lys Xaa 
    2450                 2455                 2460             


Glu Leu  Leu Xaa Glu Val Ala  Ser Val Arg Ser Arg  Leu Leu Arg 
    2465                 2470                 2475             


Asp Pro  Asp Gly Ser Ala Glu  Asp Asp Ser Leu Glu  Gln Xaa Ser 
    2480                 2485                 2490             


Leu Met  Glu Ser Ser Gly Lys  Ser Pro Leu Ser Pro  Asp Xaa Pro 
    2495                 2500                 2505             


Ser Ser  Glu Glu Val Ser Tyr  Glu Val Xaa Pro Lys  Xaa Xaa Asp 
    2510                 2515                 2520             


Val Ser  Xaa Pro Lys Pro Ala  Val Ile His Glu Cys  Ala Glu Glu 
    2525                 2530                 2535             


Asp Asp  Ser Glu Asn Gly Glu  Lys Lys Arg Phe Xaa  Pro Glu Glu 
    2540                 2545                 2550             


Glu Met  Phe Lys Met Val Xaa  Lys Ile Lys Met Phe  Asp Glu Leu 
    2555                 2560                 2565             


Glu Gln  Glu Ala Lys Gln Lys  Arg Asp Tyr Lys Lys  Glu Pro Lys 
    2570                 2575                 2580             


Gln Glu  Glu Ser Ser Ser Ser  Ser Asp Pro Asp Ala  Asp Cys Ser 
    2585                 2590                 2595             


Val Asp  Val Asp Glu Pro Lys  His Xaa Gly Ser Gly  Glu Asp Glu 
    2600                 2605                 2610             


Ser Gly  Val Pro Val Leu Val  Xaa Ser Glu Ser Arg  Lys Val Ser 
    2615                 2620                 2625             


Ser Ser  Ser Glu Ser Glu Pro  Glu Leu Ala Gln Leu  Lys Lys Gly 
    2630                 2635                 2640             


Ala Asp  Ser Gly Leu Leu Pro  Glu Pro Val Ile Arg  Val Gln Pro 
    2645                 2650                 2655             


Pro Ser  Pro Leu Pro Ser Ser  Met Asp Ser Asn Ser  Ser Pro Glu 
    2660                 2665                 2670             


Glu Val  Gln Phe Gln Pro Val  Val Ser Lys Gln Tyr  Xaa Phe Lys 
    2675                 2680                 2685             


Met Asn  Glu Asp Xaa Gln Glu  Glu Pro Gly Lys Ser  Glu Glu Glu 
    2690                 2695                 2700             


Lys Asp  Ser Glu Ser His Leu  Ala Glu Asp Arg His  Ala Val Ser 
    2705                 2710                 2715             


Xaa Glu  Ala Glu Asp Arg Ser  Tyr Asp Lys Leu Asn  Arg Asp Xaa 
    2720                 2725                 2730             


Asp Gln  Pro Lys Ile Cys Asp  Gly His Gly Cys Glu  Ala Met Ser 
    2735                 2740                 2745             


Pro Ser  Ser Ser Ala Ala Pro  Val Ser Ser Gly Leu  Gln Ser Pro 
    2750                 2755                 2760             


Xaa Gly  Asp Asp Val Asp Glu  Gln Pro Val Ile Tyr  Lys Glu Ser 
    2765                 2770                 2775             


Leu Ala  Leu Gln Gly Xaa His  Glu Lys Asp Xaa Glu  Gly Glu Glu 
    2780                 2785                 2790             


Leu Asp  Val Ser Arg Ala Glu  Ser Pro Gln Ala Asp  Cys Pro Ser 
    2795                 2800                 2805             


Glu Ser  Phe Ser Ser Ser Ser  Ser Leu Pro His Cys  Leu Val Ser 
    2810                 2815                 2820             


Glu Gly  Lys Glu Leu Asp Glu  Asp Ile Ser Ala Xaa  Ser Ser Ile 
    2825                 2830                 2835             


Gln Lys  Xaa Glu Val Xaa Lys  Xaa Asp Glu Xaa Phe  Glu Asn Leu 
    2840                 2845                 2850             


Pro Lys  Asp Cys Pro Ser Gln  Asp Ser Ser Ile Xaa  Xaa Gln Xaa 
    2855                 2860                 2865             


Asp Arg  Phe Ser Met Asp Val  Pro Val Ser Asp Leu  Ala Glu Asn 
    2870                 2875                 2880             


Asp Glu  Ile Tyr Asp Pro Gln  Ile Xaa Ser Pro Tyr  Glu Asn Val 
    2885                 2890                 2895             


Pro Ser  Gln Ser Phe Phe Ser  Ser Glu Glu Ser Lys  Xaa Gln Xaa 
    2900                 2905                 2910             


Asp Ala  Asn His Xaa Xaa Ser  Phe His Ser Ser Glu  Val Tyr Ser 
    2915                 2920                 2925             


Val Xaa  Ile Xaa Ser Pro Val  Glu Asp Val Val Val  Ala Ser Ser 
    2930                 2935                 2940             


Ser Ser  Gly Xaa Val Leu Ser  Lys Glu Ser Asn Phe  Glu Gly Gln 
    2945                 2950                 2955             


Asp Ile  Lys Met Glu Ser Gln  Gln Glu Ser Xaa Leu  Trp Glu Met 
    2960                 2965                 2970             


Gln Ser  Asp Ser Val Ser Ser  Ser Phe Glu Pro Xaa  Met Ser Ala 
    2975                 2980                 2985             


Xaa Xaa  Xaa Val Val Gly Glu  Gln Ile Ser Lys Val  Ile Ile Xaa 
    2990                 2995                 3000             


Lys Xaa  Asp Val Asp Ser Asp  Ser Trp Ser Glu Ile  Arg Glu Asp 
    3005                 3010                 3015             


Asp Glu  Ala Phe Glu Ala Arg  Val Lys Glu Glu Glu  Gln Lys Ile 
    3020                 3025                 3030             


Phe Gly  Leu Met Val Asp Arg  Gln Ser Gln Gly Xaa  Xaa Pro Asp 
    3035                 3040                 3045             


Xaa Xaa  Pro Ala Arg Xaa Pro  Xaa Glu Glu Gly Xaa  Pro Xaa Ser 
    3050                 3055                 3060             


Glu Gln  Asn Pro Phe Leu Phe  Gln Glu Gly Lys Leu  Phe Glu Met 
    3065                 3070                 3075             


Xaa Arg  Ser Gly Ala Ile Asp  Met Xaa Lys Arg Ser  Tyr Ala Asp 
    3080                 3085                 3090             


Glu Ser  Phe His Phe Phe Gln  Ile Gly Gln Glu Ser  Arg Glu Glu 
    3095                 3100                 3105             


Xaa Leu  Ser Glu Asp Val Lys  Glu Gly Ala Xaa Gly  Ala Asp Pro 
    3110                 3115                 3120             


Leu Pro  Leu Glu Xaa Ser Ala  Glu Ser Leu Ala Leu  Ser Glu Ser 
    3125                 3130                 3135             


Lys Glu  Xaa Val Asp Asp Glu  Ala Asp Leu Leu Pro  Asp Asp Val 
    3140                 3145                 3150             


Ser Glu  Glu Val Glu Glu Ile  Pro Ala Ser Asp Ala  Gln Leu Asn 
    3155                 3160                 3165             


Ser Gln  Met Gly Ile Ser Ala  Ser Xaa Glu Xaa Pro  Xaa Lys Glu 
    3170                 3175                 3180             


Ala Val  Ser Val Gly Xaa Lys  Asp Leu Pro Xaa Val  Gln Xaa Gly 
    3185                 3190                 3195             


Asp Ile  Pro Pro Leu Ser Gly  Val Lys Gln Ile Ser  Cys Pro Asp 
    3200                 3205                 3210             


Ser Ser  Glu Pro Ala Val Gln  Val Gln Leu Asp Phe  Ser Xaa Leu 
    3215                 3220                 3225             


Xaa Arg  Ser Val Tyr Ser Asp  Arg Gly Asp Asp Ser  Pro Asp Ser 
    3230                 3235                 3240             


Ser Pro  Glu Glu Gln Lys Ser  Val Ile Glu Ile Pro  Xaa Ala Pro 
    3245                 3250                 3255             


Met Glu  Asn Val Pro Phe Xaa  Glu Ser Lys Ser Lys  Ile Pro Val 
    3260                 3265                 3270             


Arg Xaa  Met Pro Xaa Ser Xaa  Pro Ala Pro Pro Ser  Ala Glu Tyr 
    3275                 3280                 3285             


Glu Ser  Ser Val Ser Glu Asp  Phe Leu Ser Ser Val  Asp Glu Glu 
    3290                 3295                 3300             


Asn Lys  Ala Asp Glu Ala Lys  Pro Lys Ser Lys Leu  Pro Val Lys 
    3305                 3310                 3315             


Val Pro  Leu Gln Arg Val Glu  Gln Gln Leu Ser Asp  Leu Asp Xaa 
    3320                 3325                 3330             


Ser Val  Gln Lys Xaa Val Ala  Pro Gln Gly Gln Asp  Met Ala Ser 
    3335                 3340                 3345             


Ile Ala  Pro Asp Asn Arg Ser  Lys Ser Glu Ser Asp  Ala Ser Ser 
    3350                 3355                 3360             


Leu Asp  Ser Lys Xaa Lys Cys  Pro Val Lys Xaa Arg  Ser Tyr Xaa 
    3365                 3370                 3375             


Glu Xaa  Glu Xaa Glu Ser Arg  Glu Arg Ala Glu Glu  Leu Glu Leu 
    3380                 3385                 3390             


Glu Ser  Glu Glu Gly Ala Xaa  Arg Pro Lys Ile Leu  Xaa Ser Arg 
    3395                 3400                 3405             


Leu Pro  Val Lys Ser Arg Ser  Xaa Xaa Ser Ser Cys  Arg Gly Gly 
    3410                 3415                 3420             


Xaa Ser  Pro Xaa Lys Glu Ser  Lys Glu His Phe Phe  Asp Leu Tyr 
    3425                 3430                 3435             


Arg Asn  Ser Ile Glu Phe Phe  Glu Glu Ile Ser Asp  Glu Ala Ser 
    3440                 3445                 3450             


Lys Leu  Val Asp Arg Leu Xaa  Gln Ser Glu Arg Glu  Gln Glu Ile 
    3455                 3460                 3465             


Val Ser  Asp Asp Glu Ser Ser  Ser Ala Leu Glu Val  Ser Val Ile 
    3470                 3475                 3480             


Glu Asn  Leu Pro Pro Val Glu  Xaa Glu His Ser Val  Pro Glu Asp 
    3485                 3490                 3495             


Ile Phe  Asp Xaa Arg Pro Ile  Trp Asp Glu Ser Ile  Glu Xaa Leu 
    3500                 3505                 3510             


Ile Glu  Arg Ile Pro Asp Glu  Asn Gly His Asp His  Ala Glu Asp 
    3515                 3520                 3525             


Pro Gln  Asp Glu Gln Glu Arg  Ile Glu Glu Arg Leu  Ala Tyr Ile 
    3530                 3535                 3540             


Ala Asp  His Leu Gly Phe Ser  Trp Xaa Glu Leu Ala  Arg Glu Leu 
    3545                 3550                 3555             


Asp Phe  Xaa Glu Glu Gln Ile  His Gln Ile Arg Ile  Glu Asn Pro 
    3560                 3565                 3570             


Asn Ser  Leu Gln Asp Gln Ser  His Ala Leu Leu Lys  Tyr Trp Leu 
    3575                 3580                 3585             


Glu Arg  Asp Gly Lys His Ala  Xaa Asp Xaa Asn Leu  Val Glu Cys 
    3590                 3595                 3600             


Leu Xaa  Lys Ile Asn Arg Met  Asp Ile Val His Leu  Met Glu Xaa 
    3605                 3610                 3615             


Asn Xaa  Glu Pro Leu Gln Glu  Arg Ile Ser His Ser  Tyr Ala Glu 
    3620                 3625                 3630             


Ile Glu  Gln Xaa Ile Xaa Leu  Asp His Ser Glu Gly  Phe Ser Val 
    3635                 3640                 3645             


Leu Gln  Glu Glu Leu Cys Xaa  Ala Gln His Lys Gln  Lys Glu Glu 
    3650                 3655                 3660             


Gln Ala  Val Ser Lys Glu Ser  Glu Xaa Cys Asp His  Pro Pro Ile 
    3665                 3670                 3675             


Val Ser  Glu Glu Asp Ile Ser  Val Gly Tyr Ser Xaa  Phe Gln Asp 
    3680                 3685                 3690             


Gly Val  Pro Lys Xaa Glu Gly  Asp Ser Ser Ala Xaa  Ala Leu Phe 
    3695                 3700                 3705             


Pro Gln  Xaa His Lys Glu Gln  Val Gln Gln Asp Phe  Ser Gly Lys 
    3710                 3715                 3720             


Met Gln  Asp Leu Pro Glu Glu  Ser Ser Leu Glu Tyr  Gln Gln Glu 
    3725                 3730                 3735             


Tyr Phe  Val Xaa Xaa Pro Gly  Xaa Glu Xaa Ser Glu  Xaa Gln Lys 
    3740                 3745                 3750             


Ala Met  Ile Val Pro Ser Ser  Pro Ser Lys Xaa Pro  Glu Glu Val 
    3755                 3760                 3765             


Ser Xaa  Pro Ala Glu Glu Glu  Lys Leu Tyr Leu Gln  Xaa Pro Xaa 
    3770                 3775                 3780             


Ser Ser  Glu Arg Gly Gly Ser  Pro Ile Ile Gln Glu  Pro Glu Glu 
    3785                 3790                 3795             


Pro Ser  Glu His Arg Glu Glu  Ser Ser Pro Arg Lys  Xaa Ser Leu 
    3800                 3805                 3810             


Val Ile  Val Glu Ser Ala Asp  Asn Gln Pro Glu Xaa  Cys Glu Arg 
    3815                 3820                 3825             


Leu Asp  Glu Asp Ala Ala Phe  Glu Lys Gly Asp Asp  Met Pro Glu 
    3830                 3835                 3840             


Ile Pro  Pro Glu Xaa Val Xaa  Glu Glu Glu Tyr Ile  Asp Glu His 
    3845                 3850                 3855             


Gly His  Xaa Val Val Lys Lys  Val Xaa Arg Lys Ile  Ile Arg Arg 
    3860                 3865                 3870             


Tyr Val  Ser Ser Glu Gly Xaa  Glu Lys Glu Glu Ile  Met Val Gln 
    3875                 3880                 3885             


Gly Met  Pro Gln Glu Pro Val  Asn Ile Glu Glu Gly  Asp Gly Tyr 
    3890                 3895                 3900             


Ser Lys  Val Ile Lys Arg Val  Val Leu Lys Ser Asp  Xaa Glu Gln 
    3905                 3910                 3915             


Ser Glu  Asp Asn Asn Glu 
    3920                 


<210> 2302
<211> 3957
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1071)..(1071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1189)..(1189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1221)..(1221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1234)..(1234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1268)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1277)..(1277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1357)..(1357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1393)..(1393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1437)..(1437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1451)..(1451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1456)..(1456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1479)..(1479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1482)..(1482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1484)..(1484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1518)..(1518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1522)..(1523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1570)..(1570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1572)..(1572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1612)..(1612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1634)..(1634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1641)..(1641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1687)..(1687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1690)..(1690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1750)..(1750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1801)..(1802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1827)..(1827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1832)..(1832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1839)..(1839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1851)..(1851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1863)..(1863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1875)..(1875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1885)..(1885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1887)..(1887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1896)..(1896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1898)..(1898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1910)..(1910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1922)..(1922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1933)..(1933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1945)..(1945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1953)..(1953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1957)..(1957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1969)..(1969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1978)..(1978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1981)..(1981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1987)..(1987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2008)..(2008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2038)..(2038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2045)..(2045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2049)..(2049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2059)..(2059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2061)..(2061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2132)..(2132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2134)..(2134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2159)..(2159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2171)..(2171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2176)..(2177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2222)..(2222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2239)..(2239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2242)..(2242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2258)..(2258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2261)..(2261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2265)..(2265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2267)..(2267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2269)..(2271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2281)..(2282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2286)..(2286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2295)..(2295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2297)..(2297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2302)..(2302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2304)..(2304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2312)..(2312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2319)..(2319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2328)..(2328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2339)..(2339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2341)..(2341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2344)..(2344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2355)..(2355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2363)..(2363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2365)..(2365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2373)..(2373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2375)..(2375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2379)..(2379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2391)..(2391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2393)..(2393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2395)..(2395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2451)..(2451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2496)..(2496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2500)..(2500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2525)..(2525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2540)..(2540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2551)..(2551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2554)..(2555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2559)..(2559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2583)..(2583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2593)..(2593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2640)..(2640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2654)..(2654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2719)..(2719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2726)..(2726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2752)..(2752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2766)..(2766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2797)..(2797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2817)..(2817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2822)..(2822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2868)..(2868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2874)..(2874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2877)..(2877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2879)..(2879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2882)..(2882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2898)..(2899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2901)..(2901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2925)..(2925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2944)..(2944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2946)..(2946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2951)..(2952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2963)..(2963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2965)..(2965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2980)..(2980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3002)..(3002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3018)..(3018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3022)..(3024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3036)..(3036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3038)..(3038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3078)..(3079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3082)..(3083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3087)..(3087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3089)..(3089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3093)..(3093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3095)..(3095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3112)..(3112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3120)..(3120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3142)..(3142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3152)..(3152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3161)..(3161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3174)..(3174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3210)..(3210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3212)..(3212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3214)..(3214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3222)..(3222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3227)..(3227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3230)..(3230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3260)..(3260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3262)..(3262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3289)..(3289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3298)..(3298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3308)..(3308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3311)..(3311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3313)..(3313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3366)..(3366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3371)..(3371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3401)..(3401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3407)..(3407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3411)..(3411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3413)..(3413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3415)..(3415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3433)..(3433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3439)..(3439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3449)..(3450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3457)..(3457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3460)..(3460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3493)..(3493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3524)..(3524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3535)..(3535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3545)..(3545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3585)..(3585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3594)..(3594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3629)..(3629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3631)..(3631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3638)..(3638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3651)..(3651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3653)..(3653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3670)..(3670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3672)..(3672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3688)..(3688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3705)..(3705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3723)..(3723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3731)..(3731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3738)..(3738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3744)..(3744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3775)..(3776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3779)..(3779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3781)..(3781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3784)..(3784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3797)..(3797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3803)..(3803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3814)..(3814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3816)..(3816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3844)..(3844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3858)..(3858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3881)..(3881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3883)..(3883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3894)..(3894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3900)..(3900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3913)..(3913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3949)..(3949)
<223> Selenocysteine

<400> 2302
Met Met Asn Glu Asp Ala Ala Gln Lys Ser Asp Ser Gly Glu Lys Phe 
1               5                   10                  15      


Asn Gly Ser Ser Gln Arg Arg Lys Arg Pro Lys Lys Ser Asp Ser Asn 
            20                  25                  30          


Ala Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val 
        35                  40                  45              


Glu Tyr Leu Lys Gly Gly Ile Asp Ile Asn Xaa Cys Asn Gln Asn Gly 
    50                  55                  60                  


Leu Asn Ala Leu His Leu Ala Ala Lys Glu Gly His Val Gly Leu Val 
65                  70                  75                  80  


Gln Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser Ala Xaa Lys Lys 
                85                  90                  95      


Gly Asn Xaa Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val 
            100                 105                 110         


Val Lys Val Leu Val Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln 
        115                 120                 125             


Asn Gly Phe Xaa Pro Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp 
    130                 135                 140                 


Val Val Lys Tyr Leu Leu Glu Asn Gly Ala Asn Gln Ser Xaa Ala Xaa 
145                 150                 155                 160 


Glu Asp Gly Phe Xaa Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn 
                165                 170                 175     


Gln Ala Val Ala Ile Leu Leu Glu Asn Asp Xaa Lys Gly Lys Val Arg 
            180                 185                 190         


Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp Xaa Lys Ser Ala 
        195                 200                 205             


Ala Leu Leu Leu Gln Asn Asp His Asn Ala Asp Val Gln Ser Lys Met 
    210                 215                 220                 


Met Val Asn Arg Xaa Xaa Glu Ser Gly Phe Xaa Pro Leu His Ile Ala 
225                 230                 235                 240 


Ala His Tyr Gly Asn Val Asn Val Ala Xaa Leu Leu Leu Asn Arg Gly 
                245                 250                 255     


Ala Ala Val Asp Phe Xaa Ala Arg Asn Gly Ile Xaa Pro Leu His Val 
            260                 265                 270         


Ala Ser Lys Arg Gly Asn Xaa Asn Met Val Lys Leu Leu Leu Asp Arg 
        275                 280                 285             


Gly Gly Gln Ile Asp Ala Lys Xaa Arg Asp Gly Leu Xaa Pro Leu His 
    290                 295                 300                 


Cys Ala Ala Arg Ser Gly His Asp Gln Val Val Glu Leu Leu Leu Glu 
305                 310                 315                 320 


Arg Gly Ala Pro Leu Leu Ala Arg Xaa Lys Asn Gly Leu Ser Pro Leu 
                325                 330                 335     


His Met Ala Ala Gln Gly Asp His Val Glu Cys Val Lys His Leu Leu 
            340                 345                 350         


Gln His Lys Ala Pro Val Asp Asp Val Xaa Leu Asp Tyr Leu Xaa Ala 
        355                 360                 365             


Leu His Val Ala Ala His Cys Gly His Tyr Arg Val Xaa Lys Leu Leu 
    370                 375                 380                 


Leu Asp Lys Arg Ala Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Xaa 
385                 390                 395                 400 


Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu 
                405                 410                 415     


Leu Val Lys Tyr Gly Ala Ser Ile Gln Ala Ile Xaa Glu Ser Gly Leu 
            420                 425                 430         


Xaa Pro Ile His Val Ala Ala Phe Met Gly His Leu Asn Ile Val Leu 
        435                 440                 445             


Leu Leu Leu Gln Asn Gly Ala Ser Pro Asp Val Xaa Asn Ile Arg Gly 
    450                 455                 460                 


Glu Xaa Ala Leu His Met Ala Ala Arg Ala Gly Gln Val Glu Val Val 
465                 470                 475                 480 


Arg Cys Leu Leu Arg Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu 
                485                 490                 495     


Glu Gln Xaa Pro Leu His Ile Ala Ser Arg Leu Gly Lys Xaa Glu Ile 
            500                 505                 510         


Val Gln Leu Leu Leu Gln His Met Ala His Pro Asp Ala Ala Xaa Xaa 
        515                 520                 525             


Asn Gly Tyr Xaa Pro Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp 
    530                 535                 540                 


Val Ala Ser Val Leu Leu Glu Ala Gly Ala Ala His Ser Leu Ala Xaa 
545                 550                 555                 560 


Lys Lys Gly Phe Xaa Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu 
                565                 570                 575     


Asp Val Ala Lys Leu Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala 
            580                 585                 590         


Gly Lys Asn Gly Leu Xaa Pro Leu His Val Ala Ala His Tyr Asp Asn 
        595                 600                 605             


Gln Lys Val Ala Leu Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala 
    610                 615                 620                 


Xaa Ala Lys Asn Gly Tyr Xaa Pro Leu His Ile Ala Ala Lys Lys Asn 
625                 630                 635                 640 


Gln Met Gln Ile Ala Ser Xaa Leu Leu Asn Tyr Gly Ala Glu Xaa Asn 
                645                 650                 655     


Ile Val Xaa Lys Gln Gly Val Xaa Pro Leu His Leu Ala Ser Gln Glu 
            660                 665                 670         


Gly His Xaa Asp Met Val Xaa Leu Leu Leu Asp Lys Gly Ala Asn Ile 
        675                 680                 685             


His Met Ser Xaa Lys Ser Gly Leu Xaa Ser Leu His Leu Ala Ala Gln 
    690                 695                 700                 


Glu Asp Lys Val Asn Val Ala Asp Ile Leu Xaa Lys His Gly Ala Asp 
705                 710                 715                 720 


Gln Asp Ala His Xaa Lys Leu Gly Tyr Xaa Pro Leu Ile Val Ala Cys 
                725                 730                 735     


His Tyr Gly Asn Val Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala 
            740                 745                 750         


Asn Val Asn Ala Lys Xaa Lys Asn Gly Tyr Xaa Pro Leu His Gln Ala 
        755                 760                 765             


Ala Gln Gln Gly His Xaa His Ile Ile Asn Val Leu Leu Gln His Gly 
    770                 775                 780                 


Ala Lys Pro Asn Ala Xaa Xaa Ala Asn Gly Asn Xaa Ala Leu Ala Ile 
785                 790                 795                 800 


Ala Lys Arg Leu Gly Tyr Ile Ser Val Val Asp Xaa Leu Lys Val Val 
                805                 810                 815     


Xaa Glu Glu Val Xaa Xaa Xaa Xaa Xaa Xaa Ile Xaa Glu Lys His Lys 
            820                 825                 830         


Leu Asn Val Pro Glu Xaa Met Xaa Glu Val Leu Asp Val Ser Asp Glu 
        835                 840                 845             


Glu Gly Asp Asp Xaa Met Xaa Gly Asp Gly Gly Glu Tyr Leu Arg Pro 
    850                 855                 860                 


Glu Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe 
865                 870                 875                 880 


Leu Asp Gly Met Asn Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser 
                885                 890                 895     


Asp Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser His Xaa Leu Ser His 
            900                 905                 910         


Ala Ser Tyr Leu Arg Asp Ser Ala Val Met Asp Asp Ser Val Val Ile 
        915                 920                 925             


Pro Ser His Gln Val Ser Xaa Leu Ala Lys Glu Ala Glu Arg Asn Ser 
    930                 935                 940                 


Tyr Arg Leu Ser Trp Gly Xaa Glu Asn Leu Asp Asn Val Ala Leu Ser 
945                 950                 955                 960 


Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala 
                965                 970                 975     


Arg Gly Gly Ala Met Arg Gly Cys Arg His Asn Gly Leu Arg Ile Ile 
            980                 985                 990         


Ile Pro Pro Arg Lys Cys Xaa Ala  Pro Xaa Arg Val Xaa  Cys Arg Leu 
        995                 1000                 1005             


Val Lys  Arg His Arg Leu Ala  Xaa Met Pro Pro Met  Val Glu Gly 
    1010                 1015                 1020             


Glu Gly  Leu Ala Ser Arg Leu  Ile Glu Val Gly Pro  Ser Gly Ala 
    1025                 1030                 1035             


Gln Phe  Leu Gly Lys Leu His  Leu Pro Xaa Ala Pro  Pro Pro Leu 
    1040                 1045                 1050             


Asn Glu  Gly Glu Ser Leu Val  Ser Arg Ile Leu Gln  Leu Gly Pro 
    1055                 1060                 1065             


Pro Gly  Xaa Lys Phe Leu Gly  Pro Val Ile Val Glu  Ile Pro His 
    1070                 1075                 1080             


Phe Ala  Ala Leu Arg Gly Lys  Glu Arg Glu Leu Val  Val Leu Arg 
    1085                 1090                 1095             


Ser Glu  Asn Gly Asp Ser Trp  Lys Glu His Phe Cys  Asp Tyr Xaa 
    1100                 1105                 1110             


Glu Asp  Glu Leu Asn Glu Ile  Leu Asn Gly Met Asp  Glu Val Leu 
    1115                 1120                 1125             


Asp Ser  Pro Glu Asp Leu Glu  Lys Lys Arg Ile Cys  Arg Ile Ile 
    1130                 1135                 1140             


Xaa Arg  Asp Phe Pro Gln Tyr  Phe Ala Val Val Ser  Arg Ile Lys 
    1145                 1150                 1155             


Gln Asp  Ser Asn Leu Ile Gly  Pro Glu Gly Gly Val  Leu Ser Ser 
    1160                 1165                 1170             


Xaa Val  Val Pro Gln Val Gln  Ala Val Phe Pro Glu  Gly Ala Leu 
    1175                 1180                 1185             


Xaa Lys  Arg Ile Arg Val Gly  Leu Gln Ala Gln Pro  Met His Ser 
    1190                 1195                 1200             


Glu Leu  Val Lys Lys Ile Leu  Gly Asn Lys Ala Xaa  Phe Ser Pro 
    1205                 1210                 1215             


Ile Val  Xaa Leu Glu Pro Arg  Arg Arg Lys Phe His  Lys Pro Ile 
    1220                 1225                 1230             


Xaa Met  Xaa Ile Pro Val Pro  Lys Ala Ser Ser Asp  Val Met Leu 
    1235                 1240                 1245             


Asn Gly  Phe Gly Gly Asp Ala  Pro Xaa Leu Arg Leu  Leu Cys Ser 
    1250                 1255                 1260             


Ile Xaa  Gly Gly Xaa Xaa Pro  Ala Gln Trp Glu Asp  Ile Xaa Gly 
    1265                 1270                 1275             


Xaa Xaa  Pro Leu Xaa Phe Val  Asn Glu Cys Val Ser  Phe Xaa Xaa 
    1280                 1285                 1290             


Asn Val  Ser Ala Arg Phe Trp  Leu Ile Asp Cys Arg  Gln Ile Gln 
    1295                 1300                 1305             


Glu Ser  Val Xaa Phe Ala Ser  Gln Val Tyr Arg Glu  Ile Ile Cys 
    1310                 1315                 1320             


Val Pro  Tyr Met Ala Lys Phe  Val Val Phe Ala Lys  Ser His Asp 
    1325                 1330                 1335             


Pro Ile  Glu Ala Arg Leu Arg  Cys Phe Cys Met Xaa  Asp Asp Lys 
    1340                 1345                 1350             


Val Asp  Lys Xaa Leu Glu Gln  Gln Glu Asn Phe Ala  Glu Val Ala 
    1355                 1360                 1365             


Arg Ser  Arg Asp Val Glu Val  Leu Glu Gly Lys Pro  Ile Tyr Val 
    1370                 1375                 1380             


Asp Cys  Phe Gly Asn Leu Val  Pro Leu Xaa Lys Ser  Gly Gln His 
    1385                 1390                 1395             


His Ile  Phe Ser Phe Phe Ala  Phe Lys Glu Asn Arg  Leu Pro Leu 
    1400                 1405                 1410             


Phe Val  Lys Val Arg Asp Xaa  Xaa Gln Glu Pro Cys  Gly Arg Leu 
    1415                 1420                 1425             


Ser Phe  Met Lys Glu Pro Lys  Ser Xaa Arg Gly Leu  Val His Gln 
    1430                 1435                 1440             


Ala Ile  Cys Asn Leu Asn Ile  Xaa Leu Pro Ile Tyr  Xaa Lys Glu 
    1445                 1450                 1455             


Ser Glu  Ser Asp Gln Glu Gln  Glu Glu Glu Ile Asp  Met Xaa Ser 
    1460                 1465                 1470             


Glu Lys  Asn Asp Glu Xaa Glu  Ser Xaa Glu Xaa Ser  Val Leu Lys 
    1475                 1480                 1485             


Ser His  Leu Val Asn Glu Val  Pro Val Leu Ala Ser  Pro Asp Leu 
    1490                 1495                 1500             


Leu Ser  Glu Val Ser Glu Met  Lys Gln Asp Leu Ile  Lys Met Xaa 
    1505                 1510                 1515             


Ala Ile  Leu Xaa Xaa Asp Val  Ser Asp Lys Ala Gly  Ser Ile Lys 
    1520                 1525                 1530             


Val Lys  Glu Leu Val Lys Ala  Ala Glu Glu Glu Pro  Gly Glu Pro 
    1535                 1540                 1545             


Phe Glu  Ile Val Glu Arg Val  Lys Glu Asp Leu Glu  Lys Val Asn 
    1550                 1555                 1560             


Glu Ile  Leu Arg Ser Gly Xaa  Cys Xaa Arg Asp Glu  Ser Ser Val 
    1565                 1570                 1575             


Gln Ser  Ser Arg Ser Glu Arg  Gly Leu Val Glu Glu  Glu Trp Val 
    1580                 1585                 1590             


Ile Val  Ser Asp Glu Glu Ile  Glu Glu Ala Arg Gln  Lys Ala Pro 
    1595                 1600                 1605             


Leu Glu  Ile Xaa Glu Tyr Pro  Cys Val Glu Val Arg  Ile Asp Lys 
    1610                 1615                 1620             


Glu Ile  Lys Gly Lys Val Glu  Lys Asp Ser Xaa Gly  Leu Val Asn 
    1625                 1630                 1635             


Tyr Leu  Xaa Asp Asp Leu Asn  Xaa Cys Val Pro Leu  Pro Lys Glu 
    1640                 1645                 1650             


Gln Leu  Gln Xaa Val Gln Asp  Lys Ala Gly Lys Lys  Cys Glu Ala 
    1655                 1660                 1665             


Leu Ala  Val Gly Arg Ser Ser  Glu Lys Glu Gly Lys  Asp Ile Pro 
    1670                 1675                 1680             


Pro Asp  Glu Xaa Gln Ser Xaa  Gln Lys Gln His Lys  Pro Ser Leu 
    1685                 1690                 1695             


Gly Ile  Lys Lys Pro Val Arg  Arg Lys Leu Lys Glu  Lys Gln Lys 
    1700                 1705                 1710             


Gln Lys  Glu Glu Gly Leu Gln  Ala Ser Ala Glu Lys  Ala Glu Leu 
    1715                 1720                 1725             


Lys Lys  Gly Ser Ser Glu Glu  Ser Leu Gly Glu Asp  Pro Gly Leu 
    1730                 1735                 1740             


Ala Pro  Glu Pro Leu Pro Xaa  Val Lys Ala Xaa Ser  Pro Leu Ile 
    1745                 1750                 1755             


Glu Glu  Xaa Pro Ile Gly Ser  Ile Lys Asp Lys Val  Lys Ala Leu 
    1760                 1765                 1770             


Gln Lys  Arg Val Glu Asp Glu  Gln Lys Gly Arg Ser  Lys Leu Pro 
    1775                 1780                 1785             


Ile Arg  Val Lys Gly Lys Glu  Asp Val Pro Lys Lys  Xaa Xaa His 
    1790                 1795                 1800             


Arg Pro  His Pro Ala Ala Ser  Pro Ser Leu Lys Ser  Glu Arg His 
    1805                 1810                 1815             


Ala Pro  Gly Ser Pro Ser Pro  Lys Xaa Glu Arg His  Ser Xaa Leu 
    1820                 1825                 1830             


Ser Ser  Ser Ala Lys Xaa Glu  Arg His Pro Pro Val  Ser Pro Ser 
    1835                 1840                 1845             


Ser Lys  Xaa Glu Lys His Ser  Pro Val Ser Pro Ser  Ala Lys Xaa 
    1850                 1855                 1860             


Glu Arg  His Ser Pro Ala Ser  Ser Ser Ser Lys Xaa  Glu Lys His 
    1865                 1870                 1875             


Ser Pro  Val Ser Pro Ser Xaa  Lys Xaa Glu Arg His  Ser Pro Val 
    1880                 1885                 1890             


Ser Ser  Xaa Lys Xaa Glu Arg  His Pro Pro Val Ser  Pro Ser Gly 
    1895                 1900                 1905             


Lys Xaa  Asp Lys Arg Pro Pro  Val Ser Pro Ser Gly  Arg Xaa Glu 
    1910                 1915                 1920             


Lys His  Pro Pro Val Ser Pro  Gly Arg Xaa Glu Lys  Arg Leu Pro 
    1925                 1930                 1935             


Val Ser  Pro Ser Gly Arg Xaa  Asp Lys His Gln Pro  Val Ser Xaa 
    1940                 1945                 1950             


Ala Gly  Lys Xaa Glu Lys His  Leu Pro Val Ser Pro  Ser Gly Lys 
    1955                 1960                 1965             


Xaa Glu  Lys Gln Pro Pro Val  Ser Pro Xaa Ser Lys  Xaa Glu Arg 
    1970                 1975                 1980             


Ile Glu  Glu Xaa Met Ser Val  Arg Glu Leu Met Lys  Ala Phe Gln 
    1985                 1990                 1995             


Ser Gly  Gln Asp Pro Ser Lys  His Lys Xaa Gly Leu  Phe Glu His 
    2000                 2005                 2010             


Lys Ser  Ala Lys Gln Lys Gln  Pro Gln Glu Lys Gly  Lys Val Arg 
    2015                 2020                 2025             


Val Glu  Lys Glu Lys Gly Pro  Ile Leu Xaa Gln Arg  Glu Ala Gln 
    2030                 2035                 2040             


Lys Xaa  Glu Asn Gln Xaa Ile  Lys Arg Gly Gln Arg  Leu Pro Val 
    2045                 2050                 2055             


Xaa Gly  Xaa Ala Glu Ser Lys  Arg Gly Val Arg Val  Ser Ser Ile 
    2060                 2065                 2070             


Gly Val  Lys Lys Glu Asp Ala  Ala Gly Gly Lys Glu  Lys Val Leu 
    2075                 2080                 2085             


Ser His  Lys Ile Pro Glu Pro  Val Gln Ser Val Pro  Glu Glu Glu 
    2090                 2095                 2100             


Ser His  Arg Glu Ser Glu Val  Pro Lys Glu Lys Met  Ala Asp Glu 
    2105                 2110                 2115             


Gln Gly  Asp Met Asp Leu Gln  Ile Ser Pro Asp Arg  Lys Xaa Ser 
    2120                 2125                 2130             


Xaa Asp  Phe Ser Glu Val Ile  Lys Gln Glu Leu Glu  Asp Asn Asp 
    2135                 2140                 2145             


Lys Tyr  Gln Gln Phe Arg Leu  Ser Glu Glu Xaa Glu  Lys Ala Gln 
    2150                 2155                 2160             


Leu His  Leu Asp Gln Val Leu  Xaa Ser Pro Phe Asn  Xaa Xaa Phe 
    2165                 2170                 2175             


Pro Leu  Asp Tyr Met Lys Asp  Glu Phe Leu Pro Ala  Leu Ser Leu 
    2180                 2185                 2190             


Gln Ser  Gly Ala Leu Asp Gly  Ser Ser Glu Ser Leu  Lys Asn Glu 
    2195                 2200                 2205             


Gly Val  Ala Gly Ser Pro Cys  Gly Ser Leu Met Glu  Gly Xaa Pro 
    2210                 2215                 2220             


Gln Ile  Ser Ser Glu Glu Ser  Tyr Lys His Glu Gly  Leu Ala Glu 
    2225                 2230                 2235             


Xaa Pro  Glu Xaa Ser Pro Glu  Ser Leu Ser Phe Ser  Pro Lys Lys 
    2240                 2245                 2250             


Ser Glu  Glu Gln Xaa Gly Glu  Xaa Lys Glu Ser Xaa  Lys Xaa Glu 
    2255                 2260                 2265             


Xaa Xaa  Xaa Glu Ile Arg Ser  Glu Lys Glu His Pro  Xaa Xaa Lys 
    2270                 2275                 2280             


Asp Ile  Xaa Gly Gly Ser Glu  Glu Arg Gly Ala Xaa  Val Xaa Glu 
    2285                 2290                 2295             


Asp Ser  Glu Xaa Ser Xaa Glu  Ser Phe Gln Lys Glu  Ala Xaa Leu 
    2300                 2305                 2310             


Gly Ser  Pro Lys Asp Xaa Ser  Pro Lys Arg Gln Asp  Asp Cys Xaa 
    2315                 2320                 2325             


Gly Ser  Cys Ser Val Ala Leu  Ala Lys Glu Xaa Pro  Xaa Gly Leu 
    2330                 2335                 2340             


Xaa Glu  Glu Ala Ala Cys Asp  Glu Gly Gln Arg Xaa  Phe Gly Ser 
    2345                 2350                 2355             


Ser Ala  His Lys Xaa Gln Xaa  Asp Ser Glu Val Gln  Glu Ser Xaa 
    2360                 2365                 2370             


Ala Xaa  Ser Asp Glu Xaa Lys  Ala Leu Pro Leu Pro  Glu Ala Ser 
    2375                 2380                 2385             


Val Lys  Xaa Asp Xaa Gly Xaa  Glu Ser Lys Pro Gln  Gly Val Ile 
    2390                 2395                 2400             


Arg Ser  Pro Gln Gly Leu Glu  Leu Ala Leu Pro Ser  Arg Asp Ser 
    2405                 2410                 2415             


Glu Val  Leu Ser Ala Val Ala  Asp Asp Ser Leu Ala  Val Ser His 
    2420                 2425                 2430             


Lys Asp  Ser Leu Glu Ala Ser  Pro Val Leu Glu Asp  Asn Ser Ser 
    2435                 2440                 2445             


His Lys  Xaa Pro Asp Ser Leu  Glu Pro Ser Pro Leu  Lys Glu Ser 
    2450                 2455                 2460             


Pro Cys  Arg Asp Ser Leu Glu  Ser Ser Pro Val Glu  Pro Lys Met 
    2465                 2470                 2475             


Lys Ala  Gly Ile Phe Pro Ser  His Phe Pro Leu Pro  Ala Ala Val 
    2480                 2485                 2490             


Ala Lys  Xaa Glu Leu Leu Xaa  Glu Val Ala Ser Val  Arg Ser Arg 
    2495                 2500                 2505             


Leu Leu  Arg Asp Pro Asp Gly  Ser Ala Glu Asp Asp  Ser Leu Glu 
    2510                 2515                 2520             


Gln Xaa  Ser Leu Met Glu Ser  Ser Gly Lys Ser Pro  Leu Ser Pro 
    2525                 2530                 2535             


Asp Xaa  Pro Ser Ser Glu Glu  Val Ser Tyr Glu Val  Xaa Pro Lys 
    2540                 2545                 2550             


Xaa Xaa  Asp Val Ser Xaa Pro  Lys Pro Ala Val Ile  His Glu Cys 
    2555                 2560                 2565             


Ala Glu  Glu Asp Asp Ser Glu  Asn Gly Glu Lys Lys  Arg Phe Xaa 
    2570                 2575                 2580             


Pro Glu  Glu Glu Met Phe Lys  Met Val Xaa Lys Ile  Lys Met Phe 
    2585                 2590                 2595             


Asp Glu  Leu Glu Gln Glu Ala  Lys Gln Lys Arg Asp  Tyr Lys Lys 
    2600                 2605                 2610             


Glu Pro  Lys Gln Glu Glu Ser  Ser Ser Ser Ser Asp  Pro Asp Ala 
    2615                 2620                 2625             


Asp Cys  Ser Val Asp Val Asp  Glu Pro Lys His Xaa  Gly Ser Gly 
    2630                 2635                 2640             


Glu Asp  Glu Ser Gly Val Pro  Val Leu Val Xaa Ser  Glu Ser Arg 
    2645                 2650                 2655             


Lys Val  Ser Ser Ser Ser Glu  Ser Glu Pro Glu Leu  Ala Gln Leu 
    2660                 2665                 2670             


Lys Lys  Gly Ala Asp Ser Gly  Leu Leu Pro Glu Pro  Val Ile Arg 
    2675                 2680                 2685             


Val Gln  Pro Pro Ser Pro Leu  Pro Ser Ser Met Asp  Ser Asn Ser 
    2690                 2695                 2700             


Ser Pro  Glu Glu Val Gln Phe  Gln Pro Val Val Ser  Lys Gln Tyr 
    2705                 2710                 2715             


Xaa Phe  Lys Met Asn Glu Asp  Xaa Gln Glu Glu Pro  Gly Lys Ser 
    2720                 2725                 2730             


Glu Glu  Glu Lys Asp Ser Glu  Ser His Leu Ala Glu  Asp Arg His 
    2735                 2740                 2745             


Ala Val  Ser Xaa Glu Ala Glu  Asp Arg Ser Tyr Asp  Lys Leu Asn 
    2750                 2755                 2760             


Arg Asp  Xaa Asp Gln Pro Lys  Ile Cys Asp Gly His  Gly Cys Glu 
    2765                 2770                 2775             


Ala Met  Ser Pro Ser Ser Ser  Ala Ala Pro Val Ser  Ser Gly Leu 
    2780                 2785                 2790             


Gln Ser  Pro Xaa Gly Asp Asp  Val Asp Glu Gln Pro  Val Ile Tyr 
    2795                 2800                 2805             


Lys Glu  Ser Leu Ala Leu Gln  Gly Xaa His Glu Lys  Asp Xaa Glu 
    2810                 2815                 2820             


Gly Glu  Glu Leu Asp Val Ser  Arg Ala Glu Ser Pro  Gln Ala Asp 
    2825                 2830                 2835             


Cys Pro  Ser Glu Ser Phe Ser  Ser Ser Ser Ser Leu  Pro His Cys 
    2840                 2845                 2850             


Leu Val  Ser Glu Gly Lys Glu  Leu Asp Glu Asp Ile  Ser Ala Xaa 
    2855                 2860                 2865             


Ser Ser  Ile Gln Lys Xaa Glu  Val Xaa Lys Xaa Asp  Glu Xaa Phe 
    2870                 2875                 2880             


Glu Asn  Leu Pro Lys Asp Cys  Pro Ser Gln Asp Ser  Ser Ile Xaa 
    2885                 2890                 2895             


Xaa Gln  Xaa Asp Arg Phe Ser  Met Asp Val Pro Val  Ser Asp Leu 
    2900                 2905                 2910             


Ala Glu  Asn Asp Glu Ile Tyr  Asp Pro Gln Ile Xaa  Ser Pro Tyr 
    2915                 2920                 2925             


Glu Asn  Val Pro Ser Gln Ser  Phe Phe Ser Ser Glu  Glu Ser Lys 
    2930                 2935                 2940             


Xaa Gln  Xaa Asp Ala Asn His  Xaa Xaa Ser Phe His  Ser Ser Glu 
    2945                 2950                 2955             


Val Tyr  Ser Val Xaa Ile Xaa  Ser Pro Val Glu Asp  Val Val Val 
    2960                 2965                 2970             


Ala Ser  Ser Ser Ser Gly Xaa  Val Leu Ser Lys Glu  Ser Asn Phe 
    2975                 2980                 2985             


Glu Gly  Gln Asp Ile Lys Met  Glu Ser Gln Gln Glu  Ser Xaa Leu 
    2990                 2995                 3000             


Trp Glu  Met Gln Ser Asp Ser  Val Ser Ser Ser Phe  Glu Pro Xaa 
    3005                 3010                 3015             


Met Ser  Ala Xaa Xaa Xaa Val  Val Gly Glu Gln Ile  Ser Lys Val 
    3020                 3025                 3030             


Ile Ile  Xaa Lys Xaa Asp Val  Asp Ser Asp Ser Trp  Ser Glu Ile 
    3035                 3040                 3045             


Arg Glu  Asp Asp Glu Ala Phe  Glu Ala Arg Val Lys  Glu Glu Glu 
    3050                 3055                 3060             


Gln Lys  Ile Phe Gly Leu Met  Val Asp Arg Gln Ser  Gln Gly Xaa 
    3065                 3070                 3075             


Xaa Pro  Asp Xaa Xaa Pro Ala  Arg Xaa Pro Xaa Glu  Glu Gly Xaa 
    3080                 3085                 3090             


Pro Xaa  Ser Glu Gln Asn Pro  Phe Leu Phe Gln Glu  Gly Lys Leu 
    3095                 3100                 3105             


Phe Glu  Met Xaa Arg Ser Gly  Ala Ile Asp Met Xaa  Lys Arg Ser 
    3110                 3115                 3120             


Tyr Ala  Asp Glu Ser Phe His  Phe Phe Gln Ile Gly  Gln Glu Ser 
    3125                 3130                 3135             


Arg Glu  Glu Xaa Leu Ser Glu  Asp Val Lys Glu Gly  Ala Xaa Gly 
    3140                 3145                 3150             


Ala Asp  Pro Leu Pro Leu Glu  Xaa Ser Ala Glu Ser  Leu Ala Leu 
    3155                 3160                 3165             


Ser Glu  Ser Lys Glu Xaa Val  Asp Asp Glu Ala Asp  Leu Leu Pro 
    3170                 3175                 3180             


Asp Asp  Val Ser Glu Glu Val  Glu Glu Ile Pro Ala  Ser Asp Ala 
    3185                 3190                 3195             


Gln Leu  Asn Ser Gln Met Gly  Ile Ser Ala Ser Xaa  Glu Xaa Pro 
    3200                 3205                 3210             


Xaa Lys  Glu Ala Val Ser Val  Gly Xaa Lys Asp Leu  Pro Xaa Val 
    3215                 3220                 3225             


Gln Xaa  Gly Asp Ile Pro Pro  Leu Ser Gly Val Lys  Gln Ile Ser 
    3230                 3235                 3240             


Cys Pro  Asp Ser Ser Glu Pro  Ala Val Gln Val Gln  Leu Asp Phe 
    3245                 3250                 3255             


Ser Xaa  Leu Xaa Arg Ser Val  Tyr Ser Asp Arg Gly  Asp Asp Ser 
    3260                 3265                 3270             


Pro Asp  Ser Ser Pro Glu Glu  Gln Lys Ser Val Ile  Glu Ile Pro 
    3275                 3280                 3285             


Xaa Ala  Pro Met Glu Asn Val  Pro Phe Xaa Glu Ser  Lys Ser Lys 
    3290                 3295                 3300             


Ile Pro  Val Arg Xaa Met Pro  Xaa Ser Xaa Pro Ala  Pro Pro Ser 
    3305                 3310                 3315             


Ala Glu  Tyr Glu Ser Ser Val  Ser Glu Asp Phe Leu  Ser Ser Val 
    3320                 3325                 3330             


Asp Glu  Glu Asn Lys Ala Asp  Glu Ala Lys Pro Lys  Ser Lys Leu 
    3335                 3340                 3345             


Pro Val  Lys Val Pro Leu Gln  Arg Val Glu Gln Gln  Leu Ser Asp 
    3350                 3355                 3360             


Leu Asp  Xaa Ser Val Gln Lys  Xaa Val Ala Pro Gln  Gly Gln Asp 
    3365                 3370                 3375             


Met Ala  Ser Ile Ala Pro Asp  Asn Arg Ser Lys Ser  Glu Ser Asp 
    3380                 3385                 3390             


Ala Ser  Ser Leu Asp Ser Lys  Xaa Lys Cys Pro Val  Lys Xaa Arg 
    3395                 3400                 3405             


Ser Tyr  Xaa Glu Xaa Glu Xaa  Glu Ser Arg Glu Arg  Ala Glu Glu 
    3410                 3415                 3420             


Leu Glu  Leu Glu Ser Glu Glu  Gly Ala Xaa Arg Pro  Lys Ile Leu 
    3425                 3430                 3435             


Xaa Ser  Arg Leu Pro Val Lys  Ser Arg Ser Xaa Xaa  Ser Ser Cys 
    3440                 3445                 3450             


Arg Gly  Gly Xaa Ser Pro Xaa  Lys Glu Ser Lys Glu  His Phe Phe 
    3455                 3460                 3465             


Asp Leu  Tyr Arg Asn Ser Ile  Glu Phe Phe Glu Glu  Ile Ser Asp 
    3470                 3475                 3480             


Glu Ala  Ser Lys Leu Val Asp  Arg Leu Xaa Gln Ser  Glu Arg Glu 
    3485                 3490                 3495             


Gln Glu  Ile Val Ser Asp Asp  Glu Ser Ser Ser Ala  Leu Glu Val 
    3500                 3505                 3510             


Ser Val  Ile Glu Asn Leu Pro  Pro Val Glu Xaa Glu  His Ser Val 
    3515                 3520                 3525             


Pro Glu  Asp Ile Phe Asp Xaa  Arg Pro Ile Trp Asp  Glu Ser Ile 
    3530                 3535                 3540             


Glu Xaa  Leu Ile Glu Arg Ile  Pro Asp Glu Asn Gly  His Asp His 
    3545                 3550                 3555             


Ala Glu  Asp Pro Gln Asp Glu  Gln Glu Arg Ile Glu  Glu Arg Leu 
    3560                 3565                 3570             


Ala Tyr  Ile Ala Asp His Leu  Gly Phe Ser Trp Xaa  Glu Leu Ala 
    3575                 3580                 3585             


Arg Glu  Leu Asp Phe Xaa Glu  Glu Gln Ile His Gln  Ile Arg Ile 
    3590                 3595                 3600             


Glu Asn  Pro Asn Ser Leu Gln  Asp Gln Ser His Ala  Leu Leu Lys 
    3605                 3610                 3615             


Tyr Trp  Leu Glu Arg Asp Gly  Lys His Ala Xaa Asp  Xaa Asn Leu 
    3620                 3625                 3630             


Val Glu  Cys Leu Xaa Lys Ile  Asn Arg Met Asp Ile  Val His Leu 
    3635                 3640                 3645             


Met Glu  Xaa Asn Xaa Glu Pro  Leu Gln Glu Arg Ile  Ser His Ser 
    3650                 3655                 3660             


Tyr Ala  Glu Ile Glu Gln Xaa  Ile Xaa Leu Asp His  Ser Glu Gly 
    3665                 3670                 3675             


Phe Ser  Val Leu Gln Glu Glu  Leu Cys Xaa Ala Gln  His Lys Gln 
    3680                 3685                 3690             


Lys Glu  Glu Gln Ala Val Ser  Lys Glu Ser Glu Xaa  Cys Asp His 
    3695                 3700                 3705             


Pro Pro  Ile Val Ser Glu Glu  Asp Ile Ser Val Gly  Tyr Ser Xaa 
    3710                 3715                 3720             


Phe Gln  Asp Gly Val Pro Lys  Xaa Glu Gly Asp Ser  Ser Ala Xaa 
    3725                 3730                 3735             


Ala Leu  Phe Pro Gln Xaa His  Lys Glu Gln Val Gln  Gln Asp Phe 
    3740                 3745                 3750             


Ser Gly  Lys Met Gln Asp Leu  Pro Glu Glu Ser Ser  Leu Glu Tyr 
    3755                 3760                 3765             


Gln Gln  Glu Tyr Phe Val Xaa  Xaa Pro Gly Xaa Glu  Xaa Ser Glu 
    3770                 3775                 3780             


Xaa Gln  Lys Ala Met Ile Val  Pro Ser Ser Pro Ser  Lys Xaa Pro 
    3785                 3790                 3795             


Glu Glu  Val Ser Xaa Pro Ala  Glu Glu Glu Lys Leu  Tyr Leu Gln 
    3800                 3805                 3810             


Xaa Pro  Xaa Ser Ser Glu Arg  Gly Gly Ser Pro Ile  Ile Gln Glu 
    3815                 3820                 3825             


Pro Glu  Glu Pro Ser Glu His  Arg Glu Glu Ser Ser  Pro Arg Lys 
    3830                 3835                 3840             


Xaa Ser  Leu Val Ile Val Glu  Ser Ala Asp Asn Gln  Pro Glu Xaa 
    3845                 3850                 3855             


Cys Glu  Arg Leu Asp Glu Asp  Ala Ala Phe Glu Lys  Gly Asp Asp 
    3860                 3865                 3870             


Met Pro  Glu Ile Pro Pro Glu  Xaa Val Xaa Glu Glu  Glu Tyr Ile 
    3875                 3880                 3885             


Asp Glu  His Gly His Xaa Val  Val Lys Lys Val Xaa  Arg Lys Ile 
    3890                 3895                 3900             


Ile Arg  Arg Tyr Val Ser Ser  Glu Gly Xaa Glu Lys  Glu Glu Ile 
    3905                 3910                 3915             


Met Val  Gln Gly Met Pro Gln  Glu Pro Val Asn Ile  Glu Glu Gly 
    3920                 3925                 3930             


Asp Gly  Tyr Ser Lys Val Ile  Lys Arg Val Val Leu  Lys Ser Asp 
    3935                 3940                 3945             


Xaa Glu  Gln Ser Glu Asp Asn  Asn Glu 
    3950                 3955         


<210> 2303
<211> 1730
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1017)..(1017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1128)..(1128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1189)..(1189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1272)..(1272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1280)..(1280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1294)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1298)..(1298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1327)..(1327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1365)..(1365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1372)..(1372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1435)..(1436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1452)..(1452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1466)..(1466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1471)..(1471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1487)..(1487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1494)..(1494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1497)..(1497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1499)..(1499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1533)..(1533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1537)..(1538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1585)..(1585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1587)..(1587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1627)..(1627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1649)..(1649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1656)..(1656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1661)..(1661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1672)..(1672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1702)..(1702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1705)..(1705)
<223> Selenocysteine

<400> 2303
Met Met Asn Glu Asp Ala Ala Gln Lys Ser Asp Ser Gly Glu Lys Phe 
1               5                   10                  15      


Asn Gly Ser Ser Gln Arg Arg Lys Arg Pro Lys Lys Val Xaa Cys Pro 
            20                  25                  30          


Gln Met Lys Pro Glu Ala Ala Asn Ile Glu Lys Ser Asp Ser Asn Ala 
        35                  40                  45              


Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val Glu 
    50                  55                  60                  


Tyr Leu Lys Gly Gly Ile Asp Ile Asn Xaa Cys Asn Gln Asn Gly Leu 
65                  70                  75                  80  


Asn Ala Leu His Leu Ala Ala Lys Glu Gly His Val Gly Leu Val Gln 
                85                  90                  95      


Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser Ala Xaa Lys Lys Gly 
            100                 105                 110         


Asn Xaa Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val Val 
        115                 120                 125             


Lys Val Leu Val Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln Asn 
    130                 135                 140                 


Gly Phe Xaa Pro Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp Val 
145                 150                 155                 160 


Val Lys Tyr Leu Leu Glu Asn Gly Ala Asn Gln Ser Xaa Ala Xaa Glu 
                165                 170                 175     


Asp Gly Phe Xaa Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn Gln 
            180                 185                 190         


Ala Val Ala Ile Leu Leu Glu Asn Asp Xaa Lys Gly Lys Val Arg Leu 
        195                 200                 205             


Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp Xaa Lys Ser Ala Ala 
    210                 215                 220                 


Leu Leu Leu Gln Asn Asp His Asn Ala Asp Val Gln Ser Lys Met Met 
225                 230                 235                 240 


Val Asn Arg Xaa Xaa Glu Ser Gly Phe Xaa Pro Leu His Ile Ala Ala 
                245                 250                 255     


His Tyr Gly Asn Val Asn Val Ala Xaa Leu Leu Leu Asn Arg Gly Ala 
            260                 265                 270         


Ala Val Asp Phe Xaa Ala Arg Asn Gly Ile Xaa Pro Leu His Val Ala 
        275                 280                 285             


Ser Lys Arg Gly Asn Xaa Asn Met Val Lys Leu Leu Leu Asp Arg Gly 
    290                 295                 300                 


Gly Gln Ile Asp Ala Lys Xaa Arg Asp Gly Leu Xaa Pro Leu His Cys 
305                 310                 315                 320 


Ala Ala Arg Ser Gly His Asp Gln Val Val Glu Leu Leu Leu Glu Arg 
                325                 330                 335     


Gly Ala Pro Leu Leu Ala Arg Xaa Lys Asn Gly Leu Ser Pro Leu His 
            340                 345                 350         


Met Ala Ala Gln Gly Asp His Val Glu Cys Val Lys His Leu Leu Gln 
        355                 360                 365             


His Lys Ala Pro Val Asp Asp Val Xaa Leu Asp Tyr Leu Xaa Ala Leu 
    370                 375                 380                 


His Val Ala Ala His Cys Gly His Tyr Arg Val Xaa Lys Leu Leu Leu 
385                 390                 395                 400 


Asp Lys Arg Ala Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Xaa Pro 
                405                 410                 415     


Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu Leu 
            420                 425                 430         


Val Lys Tyr Gly Ala Ser Ile Gln Ala Ile Xaa Glu Ser Gly Leu Xaa 
        435                 440                 445             


Pro Ile His Val Ala Ala Phe Met Gly His Leu Asn Ile Val Leu Leu 
    450                 455                 460                 


Leu Leu Gln Asn Gly Ala Ser Pro Asp Val Xaa Asn Ile Arg Gly Glu 
465                 470                 475                 480 


Xaa Ala Leu His Met Ala Ala Arg Ala Gly Gln Val Glu Val Val Arg 
                485                 490                 495     


Cys Leu Leu Arg Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu Glu 
            500                 505                 510         


Gln Xaa Pro Leu His Ile Ala Ser Arg Leu Gly Lys Xaa Glu Ile Val 
        515                 520                 525             


Gln Leu Leu Leu Gln His Met Ala His Pro Asp Ala Ala Xaa Xaa Asn 
    530                 535                 540                 


Gly Tyr Xaa Pro Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp Val 
545                 550                 555                 560 


Ala Ser Val Leu Leu Glu Ala Gly Ala Ala His Ser Leu Ala Xaa Lys 
                565                 570                 575     


Lys Gly Phe Xaa Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu Asp 
            580                 585                 590         


Val Ala Lys Leu Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala Gly 
        595                 600                 605             


Lys Asn Gly Leu Xaa Pro Leu His Val Ala Ala His Tyr Asp Asn Gln 
    610                 615                 620                 


Lys Val Ala Leu Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala Xaa 
625                 630                 635                 640 


Ala Lys Asn Gly Tyr Xaa Pro Leu His Ile Ala Ala Lys Lys Asn Gln 
                645                 650                 655     


Met Gln Ile Ala Ser Xaa Leu Leu Asn Tyr Gly Ala Glu Xaa Asn Ile 
            660                 665                 670         


Val Xaa Lys Gln Gly Val Xaa Pro Leu His Leu Ala Ser Gln Glu Gly 
        675                 680                 685             


His Xaa Asp Met Val Xaa Leu Leu Leu Asp Lys Gly Ala Asn Ile His 
    690                 695                 700                 


Met Ser Xaa Lys Ser Gly Leu Xaa Ser Leu His Leu Ala Ala Gln Glu 
705                 710                 715                 720 


Asp Lys Val Asn Val Ala Asp Ile Leu Xaa Lys His Gly Ala Asp Gln 
                725                 730                 735     


Asp Ala His Xaa Lys Leu Gly Tyr Xaa Pro Leu Ile Val Ala Cys His 
            740                 745                 750         


Tyr Gly Asn Val Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala Asn 
        755                 760                 765             


Val Asn Ala Lys Xaa Lys Asn Gly Tyr Xaa Pro Leu His Gln Ala Ala 
    770                 775                 780                 


Gln Gln Gly His Xaa His Ile Ile Asn Val Leu Leu Gln His Gly Ala 
785                 790                 795                 800 


Lys Pro Asn Ala Xaa Xaa Ala Asn Gly Asn Xaa Ala Leu Ala Ile Ala 
                805                 810                 815     


Lys Arg Leu Gly Tyr Ile Ser Val Val Asp Xaa Leu Lys Val Val Xaa 
            820                 825                 830         


Glu Glu Val Xaa Xaa Xaa Xaa Xaa Xaa Ile Xaa Glu Lys His Lys Leu 
        835                 840                 845             


Asn Val Pro Glu Xaa Met Xaa Glu Val Leu Asp Val Ser Asp Glu Glu 
    850                 855                 860                 


Gly Asp Asp Xaa Met Xaa Gly Asp Gly Gly Glu Tyr Leu Arg Pro Glu 
865                 870                 875                 880 


Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe Leu 
                885                 890                 895     


Asp Gly Met Asn Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser Asp 
            900                 905                 910         


Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser His Xaa Leu Ser His Ala 
        915                 920                 925             


Ser Tyr Leu Arg Asp Ser Ala Val Met Asp Asp Ser Val Val Ile Pro 
    930                 935                 940                 


Ser His Gln Val Ser Xaa Leu Ala Lys Glu Ala Glu Arg Asn Ser Tyr 
945                 950                 955                 960 


Arg Leu Ser Trp Gly Xaa Glu Asn Leu Asp Asn Val Ala Leu Ser Ser 
                965                 970                 975     


Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala Arg 
            980                 985                 990         


Gly Gly Ala Met Arg Gly Cys Arg  His Asn Gly Leu Arg  Ile Ile Ile 
        995                 1000                 1005             


Pro Pro  Arg Lys Cys Xaa Ala  Pro Xaa Arg Val Xaa  Cys Arg Leu 
    1010                 1015                 1020             


Val Lys  Arg His Arg Leu Ala  Xaa Met Pro Pro Met  Val Glu Gly 
    1025                 1030                 1035             


Glu Gly  Leu Ala Ser Arg Leu  Ile Glu Val Gly Pro  Ser Gly Ala 
    1040                 1045                 1050             


Gln Phe  Leu Gly Lys Leu His  Leu Pro Xaa Ala Pro  Pro Pro Leu 
    1055                 1060                 1065             


Asn Glu  Gly Glu Ser Leu Val  Ser Arg Ile Leu Gln  Leu Gly Pro 
    1070                 1075                 1080             


Pro Gly  Xaa Lys Phe Leu Gly  Pro Val Ile Val Glu  Ile Pro His 
    1085                 1090                 1095             


Phe Ala  Ala Leu Arg Gly Lys  Glu Arg Glu Leu Val  Val Leu Arg 
    1100                 1105                 1110             


Ser Glu  Asn Gly Asp Ser Trp  Lys Glu His Phe Cys  Asp Tyr Xaa 
    1115                 1120                 1125             


Glu Asp  Glu Leu Asn Glu Ile  Leu Asn Gly Met Asp  Glu Val Leu 
    1130                 1135                 1140             


Asp Ser  Pro Glu Asp Leu Glu  Lys Lys Arg Ile Cys  Arg Ile Ile 
    1145                 1150                 1155             


Xaa Arg  Asp Phe Pro Gln Tyr  Phe Ala Val Val Ser  Arg Ile Lys 
    1160                 1165                 1170             


Gln Asp  Ser Asn Leu Ile Gly  Pro Glu Gly Gly Val  Leu Ser Ser 
    1175                 1180                 1185             


Xaa Val  Val Pro Gln Val Gln  Ala Val Phe Pro Glu  Gly Ala Leu 
    1190                 1195                 1200             


Xaa Lys  Arg Ile Arg Val Gly  Leu Gln Ala Gln Pro  Met His Ser 
    1205                 1210                 1215             


Glu Leu  Val Lys Lys Ile Leu  Gly Asn Lys Ala Xaa  Phe Ser Pro 
    1220                 1225                 1230             


Ile Val  Xaa Leu Glu Pro Arg  Arg Arg Lys Phe His  Lys Pro Ile 
    1235                 1240                 1245             


Xaa Met  Xaa Ile Pro Val Pro  Lys Ala Ser Ser Asp  Val Met Leu 
    1250                 1255                 1260             


Asn Gly  Phe Gly Gly Asp Ala  Pro Xaa Leu Arg Leu  Leu Cys Ser 
    1265                 1270                 1275             


Ile Xaa  Gly Gly Xaa Xaa Pro  Ala Gln Trp Glu Asp  Ile Xaa Gly 
    1280                 1285                 1290             


Xaa Xaa  Pro Leu Xaa Phe Val  Asn Glu Cys Val Ser  Phe Xaa Xaa 
    1295                 1300                 1305             


Asn Val  Ser Ala Arg Phe Trp  Leu Ile Asp Cys Arg  Gln Ile Gln 
    1310                 1315                 1320             


Glu Ser  Val Xaa Phe Ala Ser  Gln Val Tyr Arg Glu  Ile Ile Cys 
    1325                 1330                 1335             


Val Pro  Tyr Met Ala Lys Phe  Val Val Phe Ala Lys  Ser His Asp 
    1340                 1345                 1350             


Pro Ile  Glu Ala Arg Leu Arg  Cys Phe Cys Met Xaa  Asp Asp Lys 
    1355                 1360                 1365             


Val Asp  Lys Xaa Leu Glu Gln  Gln Glu Asn Phe Ala  Glu Val Ala 
    1370                 1375                 1380             


Arg Ser  Arg Asp Val Glu Val  Leu Glu Gly Lys Pro  Ile Tyr Val 
    1385                 1390                 1395             


Asp Cys  Phe Gly Asn Leu Val  Pro Leu Xaa Lys Ser  Gly Gln His 
    1400                 1405                 1410             


His Ile  Phe Ser Phe Phe Ala  Phe Lys Glu Asn Arg  Leu Pro Leu 
    1415                 1420                 1425             


Phe Val  Lys Val Arg Asp Xaa  Xaa Gln Glu Pro Cys  Gly Arg Leu 
    1430                 1435                 1440             


Ser Phe  Met Lys Glu Pro Lys  Ser Xaa Arg Gly Leu  Val His Gln 
    1445                 1450                 1455             


Ala Ile  Cys Asn Leu Asn Ile  Xaa Leu Pro Ile Tyr  Xaa Lys Glu 
    1460                 1465                 1470             


Ser Glu  Ser Asp Gln Glu Gln  Glu Glu Glu Ile Asp  Met Xaa Ser 
    1475                 1480                 1485             


Glu Lys  Asn Asp Glu Xaa Glu  Ser Xaa Glu Xaa Ser  Val Leu Lys 
    1490                 1495                 1500             


Ser His  Leu Val Asn Glu Val  Pro Val Leu Ala Ser  Pro Asp Leu 
    1505                 1510                 1515             


Leu Ser  Glu Val Ser Glu Met  Lys Gln Asp Leu Ile  Lys Met Xaa 
    1520                 1525                 1530             


Ala Ile  Leu Xaa Xaa Asp Val  Ser Asp Lys Ala Gly  Ser Ile Lys 
    1535                 1540                 1545             


Val Lys  Glu Leu Val Lys Ala  Ala Glu Glu Glu Pro  Gly Glu Pro 
    1550                 1555                 1560             


Phe Glu  Ile Val Glu Arg Val  Lys Glu Asp Leu Glu  Lys Val Asn 
    1565                 1570                 1575             


Glu Ile  Leu Arg Ser Gly Xaa  Cys Xaa Arg Asp Glu  Ser Ser Val 
    1580                 1585                 1590             


Gln Ser  Ser Arg Ser Glu Arg  Gly Leu Val Glu Glu  Glu Trp Val 
    1595                 1600                 1605             


Ile Val  Ser Asp Glu Glu Ile  Glu Glu Ala Arg Gln  Lys Ala Pro 
    1610                 1615                 1620             


Leu Glu  Ile Xaa Glu Tyr Pro  Cys Val Glu Val Arg  Ile Asp Lys 
    1625                 1630                 1635             


Glu Ile  Lys Gly Lys Val Glu  Lys Asp Ser Xaa Gly  Leu Val Asn 
    1640                 1645                 1650             


Tyr Leu  Xaa Asp Asp Leu Asn  Xaa Cys Val Pro Leu  Pro Lys Glu 
    1655                 1660                 1665             


Gln Leu  Gln Xaa Val Gln Asp  Lys Ala Gly Lys Lys  Cys Glu Ala 
    1670                 1675                 1680             


Leu Ala  Val Gly Arg Ser Ser  Glu Lys Glu Gly Lys  Asp Ile Pro 
    1685                 1690                 1695             


Pro Asp  Glu Xaa Gln Ser Xaa  Gln Lys Gln His Lys  Pro Ser Leu 
    1700                 1705                 1710             


Gly Ile  Lys Lys Pro Val Arg  Arg Lys Leu Lys Glu  Lys Gln Lys 
    1715                 1720                 1725             


Gln Lys  
    1730 


<210> 2304
<211> 1048
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<400> 2304
Met Asn Gly Asn Xaa Ala Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile 
1               5                   10                  15      


Ser Val Val Asp Xaa Leu Lys Val Val Xaa Glu Glu Val Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Ile Xaa Glu Lys His Lys Leu Asn Val Pro Glu Xaa Met 
        35                  40                  45              


Xaa Glu Val Leu Asp Val Ser Asp Glu Glu Gly Asp Asp Xaa Met Xaa 
    50                  55                  60                  


Gly Asp Gly Gly Glu Tyr Leu Arg Pro Glu Asp Leu Lys Glu Leu Gly 
65                  70                  75                  80  


Asp Asp Ser Leu Pro Ser Ser Gln Phe Leu Asp Gly Met Asn Tyr Leu 
                85                  90                  95      


Arg Tyr Ser Leu Glu Gly Gly Arg Ser Asp Ser Leu Arg Ser Phe Ser 
            100                 105                 110         


Ser Asp Arg Ser His Xaa Leu Ser His Ala Ser Tyr Leu Arg Asp Ser 
        115                 120                 125             


Ala Val Met Asp Asp Ser Val Val Ile Pro Ser His Gln Val Ser Xaa 
    130                 135                 140                 


Leu Ala Lys Glu Ala Glu Arg Asn Ser Tyr Arg Leu Ser Trp Gly Xaa 
145                 150                 155                 160 


Glu Asn Leu Asp Asn Val Ala Leu Ser Ser Ser Pro Ile His Ser Gly 
                165                 170                 175     


Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ala Met Arg Gly 
            180                 185                 190         


Cys Arg His Asn Gly Leu Arg Ile Ile Ile Pro Pro Arg Lys Cys Xaa 
        195                 200                 205             


Ala Pro Xaa Arg Val Xaa Cys Arg Leu Val Lys Arg His Arg Leu Ala 
    210                 215                 220                 


Xaa Met Pro Pro Met Val Glu Gly Glu Gly Leu Ala Ser Arg Leu Ile 
225                 230                 235                 240 


Glu Val Gly Pro Ser Gly Ala Gln Phe Leu Gly Pro Val Ile Val Glu 
                245                 250                 255     


Ile Pro His Phe Ala Ala Leu Arg Gly Lys Glu Arg Glu Leu Val Val 
            260                 265                 270         


Leu Arg Ser Glu Asn Gly Asp Ser Trp Lys Glu His Phe Cys Asp Tyr 
        275                 280                 285             


Xaa Glu Asp Glu Leu Asn Glu Ile Leu Asn Gly Met Asp Glu Val Leu 
    290                 295                 300                 


Asp Ser Pro Glu Asp Leu Glu Lys Lys Arg Ile Cys Arg Ile Ile Xaa 
305                 310                 315                 320 


Arg Asp Phe Pro Gln Tyr Phe Ala Val Val Ser Arg Ile Lys Gln Asp 
                325                 330                 335     


Ser Asn Leu Ile Gly Pro Glu Gly Gly Val Leu Ser Ser Xaa Val Val 
            340                 345                 350         


Pro Gln Val Gln Ala Val Phe Pro Glu Gly Ala Leu Xaa Lys Arg Ile 
        355                 360                 365             


Arg Val Gly Leu Gln Ala Gln Pro Met His Ser Glu Leu Val Lys Lys 
    370                 375                 380                 


Ile Leu Gly Asn Lys Ala Xaa Phe Ser Pro Ile Val Xaa Leu Glu Pro 
385                 390                 395                 400 


Arg Arg Arg Lys Phe His Lys Pro Ile Xaa Met Xaa Ile Pro Val Pro 
                405                 410                 415     


Lys Ala Ser Ser Asp Val Met Leu Asn Gly Phe Gly Gly Asp Ala Pro 
            420                 425                 430         


Xaa Leu Arg Leu Leu Cys Ser Ile Xaa Gly Gly Xaa Xaa Pro Ala Gln 
        435                 440                 445             


Trp Glu Asp Ile Xaa Gly Xaa Xaa Pro Leu Xaa Phe Val Asn Glu Cys 
    450                 455                 460                 


Val Ser Phe Xaa Xaa Asn Val Ser Ala Arg Phe Trp Leu Ile Asp Cys 
465                 470                 475                 480 


Arg Gln Ile Gln Glu Ser Val Xaa Phe Ala Ser Gln Val Tyr Arg Glu 
                485                 490                 495     


Ile Ile Cys Val Pro Tyr Met Ala Lys Phe Val Val Phe Ala Lys Ser 
            500                 505                 510         


His Asp Pro Ile Glu Ala Arg Leu Arg Cys Phe Cys Met Xaa Asp Asp 
        515                 520                 525             


Lys Val Asp Lys Xaa Leu Glu Gln Gln Glu Asn Phe Ala Glu Val Ala 
    530                 535                 540                 


Arg Ser Arg Asp Val Glu Val Leu Glu Gly Lys Pro Ile Tyr Val Asp 
545                 550                 555                 560 


Cys Phe Gly Asn Leu Val Pro Leu Xaa Lys Ser Gly Gln His His Ile 
                565                 570                 575     


Phe Ser Phe Phe Ala Phe Lys Glu Asn Arg Leu Pro Leu Phe Val Lys 
            580                 585                 590         


Val Arg Asp Xaa Xaa Gln Glu Pro Cys Gly Arg Leu Ser Phe Met Lys 
        595                 600                 605             


Glu Pro Lys Ser Xaa Arg Gly Leu Val His Gln Ala Ile Cys Asn Leu 
    610                 615                 620                 


Asn Ile Xaa Leu Pro Ile Tyr Xaa Lys Glu Ser Glu Ser Asp Gln Glu 
625                 630                 635                 640 


Gln Glu Glu Glu Ile Asp Met Xaa Ser Glu Lys Asn Pro Gln Asp Glu 
                645                 650                 655     


Gln Glu Arg Ile Glu Glu Arg Leu Ala Tyr Ile Ala Asp His Leu Gly 
            660                 665                 670         


Phe Ser Trp Xaa Glu Leu Ala Arg Glu Leu Asp Phe Xaa Glu Glu Gln 
        675                 680                 685             


Ile His Gln Ile Arg Ile Glu Asn Pro Asn Ser Leu Gln Asp Gln Ser 
    690                 695                 700                 


His Ala Leu Leu Lys Tyr Trp Leu Glu Arg Asp Gly Lys His Ala Xaa 
705                 710                 715                 720 


Asp Xaa Asn Leu Val Glu Cys Leu Xaa Lys Ile Asn Arg Met Asp Ile 
                725                 730                 735     


Val His Leu Met Glu Xaa Asn Xaa Glu Pro Leu Gln Glu Arg Ile Ser 
            740                 745                 750         


His Ser Tyr Ala Glu Ile Glu Gln Xaa Ile Xaa Leu Asp His Ser Glu 
        755                 760                 765             


Gly Phe Ser Val Leu Gln Glu Glu Leu Cys Xaa Ala Gln His Lys Gln 
    770                 775                 780                 


Lys Glu Glu Gln Ala Val Ser Lys Glu Ser Glu Xaa Cys Asp His Pro 
785                 790                 795                 800 


Pro Ile Val Ser Glu Glu Asp Ile Ser Val Gly Tyr Ser Xaa Phe Gln 
                805                 810                 815     


Asp Gly Val Pro Lys Xaa Glu Gly Asp Ser Ser Ala Xaa Ala Leu Phe 
            820                 825                 830         


Pro Gln Xaa His Lys Glu Gln Val Gln Gln Asp Phe Ser Gly Lys Met 
        835                 840                 845             


Gln Asp Leu Pro Glu Glu Ser Ser Leu Glu Tyr Gln Gln Glu Tyr Phe 
    850                 855                 860                 


Val Xaa Xaa Pro Gly Xaa Glu Xaa Ser Glu Xaa Gln Lys Ala Met Ile 
865                 870                 875                 880 


Val Pro Ser Ser Pro Ser Lys Xaa Pro Glu Glu Val Ser Xaa Pro Ala 
                885                 890                 895     


Glu Glu Glu Lys Leu Tyr Leu Gln Xaa Pro Xaa Ser Ser Glu Arg Gly 
            900                 905                 910         


Gly Ser Pro Ile Ile Gln Glu Pro Glu Glu Pro Ser Glu His Arg Glu 
        915                 920                 925             


Glu Ser Ser Pro Arg Lys Xaa Ser Leu Val Ile Val Glu Ser Ala Asp 
    930                 935                 940                 


Asn Gln Pro Glu Xaa Cys Glu Arg Leu Asp Glu Asp Ala Ala Phe Glu 
945                 950                 955                 960 


Lys Gly Asp Asp Met Pro Glu Ile Pro Pro Glu Xaa Val Xaa Glu Glu 
                965                 970                 975     


Glu Tyr Ile Asp Glu His Gly His Xaa Val Val Lys Lys Val Xaa Arg 
            980                 985                 990         


Lys Ile Ile Arg Arg Tyr Val Ser  Ser Glu Gly Xaa Glu  Lys Glu Glu 
        995                 1000                 1005             


Ile Met  Val Gln Gly Met Pro  Gln Glu Pro Val Asn  Ile Glu Glu 
    1010                 1015                 1020             


Gly Asp  Gly Tyr Ser Lys Val  Ile Lys Arg Val Val  Leu Lys Ser 
    1025                 1030                 1035             


Asp Xaa  Glu Gln Ser Glu Asp  Asn Asn Glu 
    1040                 1045             


<210> 2305
<211> 555
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<400> 2305
Met Xaa Asp Asp Lys Val Asp Lys Xaa Leu Glu Gln Gln Glu Asn Phe 
1               5                   10                  15      


Ala Glu Val Ala Arg Ser Arg Asp Val Glu Val Leu Glu Gly Lys Pro 
            20                  25                  30          


Ile Tyr Val Asp Cys Phe Gly Asn Leu Val Pro Leu Xaa Lys Ser Gly 
        35                  40                  45              


Gln His His Ile Phe Ser Phe Phe Ala Phe Lys Glu Asn Arg Leu Pro 
    50                  55                  60                  


Leu Phe Val Lys Val Arg Asp Xaa Xaa Gln Glu Pro Cys Gly Arg Leu 
65                  70                  75                  80  


Ser Phe Met Lys Glu Pro Lys Ser Xaa Arg Gly Leu Val His Gln Ala 
                85                  90                  95      


Ile Cys Asn Leu Asn Ile Xaa Leu Pro Ile Tyr Xaa Lys Glu Ser Glu 
            100                 105                 110         


Ser Asp Gln Glu Gln Glu Glu Glu Ile Asp Met Xaa Ser Glu Lys Asn 
        115                 120                 125             


Pro Gln Asp Glu Gln Glu Arg Ile Glu Glu Arg Leu Ala Tyr Ile Ala 
    130                 135                 140                 


Asp His Leu Gly Phe Ser Trp Xaa Glu Leu Ala Arg Glu Leu Asp Phe 
145                 150                 155                 160 


Xaa Glu Glu Gln Ile His Gln Ile Arg Ile Glu Asn Pro Asn Ser Leu 
                165                 170                 175     


Gln Asp Gln Ser His Ala Leu Leu Lys Tyr Trp Leu Glu Arg Asp Gly 
            180                 185                 190         


Lys His Ala Xaa Asp Xaa Asn Leu Val Glu Cys Leu Xaa Lys Ile Asn 
        195                 200                 205             


Arg Met Asp Ile Val His Leu Met Glu Xaa Asn Xaa Glu Pro Leu Gln 
    210                 215                 220                 


Glu Arg Ile Ser His Ser Tyr Ala Glu Ile Glu Gln Xaa Ile Xaa Leu 
225                 230                 235                 240 


Asp His Ser Glu Gly Phe Ser Val Leu Gln Glu Glu Leu Cys Xaa Ala 
                245                 250                 255     


Gln His Lys Gln Lys Glu Glu Gln Ala Val Ser Lys Glu Ser Glu Xaa 
            260                 265                 270         


Cys Asp His Pro Pro Ile Val Ser Glu Glu Asp Ile Ser Val Gly Tyr 
        275                 280                 285             


Ser Xaa Phe Gln Asp Gly Val Pro Lys Xaa Glu Gly Asp Ser Ser Ala 
    290                 295                 300                 


Xaa Ala Leu Phe Pro Gln Xaa His Lys Glu Gln Val Gln Gln Asp Phe 
305                 310                 315                 320 


Ser Gly Lys Met Gln Asp Leu Pro Glu Glu Ser Ser Leu Glu Tyr Gln 
                325                 330                 335     


Gln Glu Tyr Phe Val Xaa Xaa Pro Gly Xaa Glu Xaa Ser Glu Xaa Gln 
            340                 345                 350         


Lys Ala Met Ile Val Pro Ser Ser Pro Ser Lys Xaa Pro Glu Glu Val 
        355                 360                 365             


Ser Xaa Pro Ala Glu Glu Glu Lys Leu Tyr Leu Gln Xaa Pro Xaa Ser 
    370                 375                 380                 


Ser Glu Arg Gly Gly Ser Pro Ile Ile Gln Glu Pro Glu Glu Pro Ser 
385                 390                 395                 400 


Glu His Arg Glu Glu Ser Ser Pro Arg Lys Xaa Ser Leu Val Ile Val 
                405                 410                 415     


Glu Ser Ala Asp Asn Gln Pro Glu Xaa Cys Glu Arg Leu Asp Glu Asp 
            420                 425                 430         


Ala Ala Phe Glu Lys Glu Leu Xaa Glu Glu Leu Gly Glu Leu Glu Ala 
        435                 440                 445             


Ser Ser Asp Glu Glu Ala Met Val Xaa Xaa Arg Val Val Arg Arg Arg 
    450                 455                 460                 


Val Ile Ile Gln Gly Asp Asp Met Pro Glu Ile Pro Pro Glu Xaa Val 
465                 470                 475                 480 


Xaa Glu Glu Glu Tyr Ile Asp Glu His Gly His Xaa Val Val Lys Lys 
                485                 490                 495     


Val Xaa Arg Lys Ile Ile Arg Arg Tyr Val Ser Ser Glu Gly Xaa Glu 
            500                 505                 510         


Lys Glu Glu Ile Met Val Gln Gly Met Pro Gln Glu Pro Val Asn Ile 
        515                 520                 525             


Glu Glu Gly Asp Gly Tyr Ser Lys Val Ile Lys Arg Val Val Leu Lys 
    530                 535                 540                 


Ser Asp Xaa Glu Gln Ser Glu Asp Asn Asn Glu 
545                 550                 555 


<210> 2306
<211> 1114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<400> 2306
Met Xaa Xaa Met Leu Gln Lys Ser Asp Ser Asn Ala Ser Phe Leu Arg 
1               5                   10                  15      


Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val Glu Tyr Leu Lys Gly 
            20                  25                  30          


Gly Ile Asp Ile Asn Xaa Cys Asn Gln Asn Gly Leu Asn Ala Leu His 
        35                  40                  45              


Leu Ala Ala Lys Glu Gly His Val Gly Leu Val Gln Glu Leu Leu Gly 
    50                  55                  60                  


Arg Gly Ser Ser Val Asp Ser Ala Xaa Lys Lys Gly Asn Xaa Ala Leu 
65                  70                  75                  80  


His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val Val Lys Val Leu Val 
                85                  90                  95      


Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln Asn Gly Phe Xaa Pro 
            100                 105                 110         


Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp Val Val Lys Tyr Leu 
        115                 120                 125             


Leu Glu Asn Gly Ala Asn Gln Ser Xaa Ala Xaa Glu Asp Gly Phe Xaa 
    130                 135                 140                 


Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn Gln Ala Val Ala Ile 
145                 150                 155                 160 


Leu Leu Glu Asn Asp Xaa Lys Gly Lys Val Arg Leu Pro Ala Leu His 
                165                 170                 175     


Ile Ala Ala Arg Lys Asp Asp Xaa Lys Ser Ala Ala Leu Leu Leu Gln 
            180                 185                 190         


Asn Asp His Asn Ala Asp Val Gln Ser Lys Met Met Val Asn Arg Xaa 
        195                 200                 205             


Xaa Glu Ser Gly Phe Xaa Pro Leu His Ile Ala Ala His Tyr Gly Asn 
    210                 215                 220                 


Val Asn Val Ala Xaa Leu Leu Leu Asn Arg Gly Ala Ala Val Asp Phe 
225                 230                 235                 240 


Xaa Ala Arg Asn Gly Ile Xaa Pro Leu His Val Ala Ser Lys Arg Gly 
                245                 250                 255     


Asn Xaa Asn Met Val Lys Leu Leu Leu Asp Arg Gly Gly Gln Ile Asp 
            260                 265                 270         


Ala Lys Xaa Arg Asp Gly Leu Xaa Pro Leu His Cys Ala Ala Arg Ser 
        275                 280                 285             


Gly His Asp Gln Val Val Glu Leu Leu Leu Glu Arg Gly Ala Pro Leu 
    290                 295                 300                 


Leu Ala Arg Xaa Lys Asn Gly Leu Ser Pro Leu His Met Ala Ala Gln 
305                 310                 315                 320 


Gly Asp His Val Glu Cys Val Lys His Leu Leu Gln His Lys Ala Pro 
                325                 330                 335     


Val Asp Asp Val Xaa Leu Asp Tyr Leu Xaa Ala Leu His Val Ala Ala 
            340                 345                 350         


His Cys Gly His Tyr Arg Val Xaa Lys Leu Leu Leu Asp Lys Arg Ala 
        355                 360                 365             


Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Xaa Pro Leu His Ile Ala 
    370                 375                 380                 


Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu Leu Val Lys Tyr Gly 
385                 390                 395                 400 


Ala Ser Ile Gln Ala Ile Xaa Glu Ser Gly Leu Xaa Pro Ile His Val 
                405                 410                 415     


Ala Ala Phe Met Gly His Leu Asn Ile Val Leu Leu Leu Leu Gln Asn 
            420                 425                 430         


Gly Ala Ser Pro Asp Val Xaa Asn Ile Arg Gly Glu Xaa Ala Leu His 
        435                 440                 445             


Met Ala Ala Arg Ala Gly Gln Val Glu Val Val Arg Cys Leu Leu Arg 
    450                 455                 460                 


Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu Glu Gln Xaa Pro Leu 
465                 470                 475                 480 


His Ile Ala Ser Arg Leu Gly Lys Xaa Glu Ile Val Gln Leu Leu Leu 
                485                 490                 495     


Gln His Met Ala His Pro Asp Ala Ala Xaa Xaa Asn Gly Tyr Xaa Pro 
            500                 505                 510         


Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp Val Ala Ser Val Leu 
        515                 520                 525             


Leu Glu Ala Gly Ala Ala His Ser Leu Ala Xaa Lys Lys Gly Phe Xaa 
    530                 535                 540                 


Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu Asp Val Ala Lys Leu 
545                 550                 555                 560 


Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala Gly Lys Asn Gly Leu 
                565                 570                 575     


Xaa Pro Leu His Val Ala Ala His Tyr Asp Asn Gln Lys Val Ala Leu 
            580                 585                 590         


Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala Xaa Ala Lys Asn Gly 
        595                 600                 605             


Tyr Xaa Pro Leu His Ile Ala Ala Lys Lys Asn Gln Met Gln Ile Ala 
    610                 615                 620                 


Ser Xaa Leu Leu Asn Tyr Gly Ala Glu Xaa Asn Ile Val Xaa Lys Gln 
625                 630                 635                 640 


Gly Val Xaa Pro Leu His Leu Ala Ser Gln Glu Gly His Xaa Asp Met 
                645                 650                 655     


Val Xaa Leu Leu Leu Asp Lys Gly Ala Asn Ile His Met Ser Xaa Lys 
            660                 665                 670         


Ser Gly Leu Xaa Ser Leu His Leu Ala Ala Gln Glu Asp Lys Val Asn 
        675                 680                 685             


Val Ala Asp Ile Leu Xaa Lys His Gly Ala Asp Gln Asp Ala His Xaa 
    690                 695                 700                 


Lys Leu Gly Tyr Xaa Pro Leu Ile Val Ala Cys His Tyr Gly Asn Val 
705                 710                 715                 720 


Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala Asn Val Asn Ala Lys 
                725                 730                 735     


Xaa Lys Asn Gly Tyr Xaa Pro Leu His Gln Ala Ala Gln Gln Gly His 
            740                 745                 750         


Xaa His Ile Ile Asn Val Leu Leu Gln His Gly Ala Lys Pro Asn Ala 
        755                 760                 765             


Xaa Xaa Ala Asn Gly Asn Xaa Ala Leu Ala Ile Ala Lys Arg Leu Gly 
    770                 775                 780                 


Tyr Ile Ser Val Val Asp Xaa Leu Lys Val Val Xaa Glu Glu Val Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Ile Xaa Glu Lys His Lys Leu Asn Val Pro Glu 
                805                 810                 815     


Xaa Met Xaa Glu Val Leu Asp Val Ser Asp Glu Glu Gly Asp Asp Xaa 
            820                 825                 830         


Met Xaa Gly Asp Gly Gly Glu Tyr Leu Arg Pro Glu Asp Leu Lys Glu 
        835                 840                 845             


Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe Leu Asp Gly Met Asn 
    850                 855                 860                 


Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser Asp Ser Leu Arg Ser 
865                 870                 875                 880 


Phe Ser Ser Asp Arg Ser His Xaa Leu Ser His Ala Ser Tyr Leu Arg 
                885                 890                 895     


Asp Ser Ala Val Met Asp Asp Ser Val Val Ile Pro Ser His Gln Val 
            900                 905                 910         


Ser Xaa Leu Ala Lys Glu Ala Glu Arg Asn Ser Tyr Arg Leu Ser Trp 
        915                 920                 925             


Gly Xaa Glu Asn Leu Asp Asn Val Ala Leu Ser Ser Ser Pro Ile His 
    930                 935                 940                 


Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ala Met 
945                 950                 955                 960 


Arg Gly Cys Arg His Asn Gly Leu Arg Ile Ile Ile Pro Pro Arg Lys 
                965                 970                 975     


Cys Xaa Ala Pro Xaa Arg Val Xaa Cys Arg Leu Val Lys Arg His Arg 
            980                 985                 990         


Leu Ala Xaa Met Pro Pro Met Val  Glu Gly Glu Gly Leu  Ala Ser Arg 
        995                 1000                 1005             


Leu Ile  Glu Val Gly Pro Ser  Gly Ala Gln Phe Leu  Gly Lys Leu 
    1010                 1015                 1020             


His Leu  Pro Xaa Ala Pro Pro  Pro Leu Asn Glu Gly  Glu Ser Leu 
    1025                 1030                 1035             


Val Ser  Arg Ile Leu Gln Leu  Gly Pro Pro Gly Xaa  Lys Phe Leu 
    1040                 1045                 1050             


Gly Pro  Val Ile Val Glu Ile  Pro His Phe Ala Ala  Leu Arg Gly 
    1055                 1060                 1065             


Lys Glu  Arg Glu Leu Val Val  Leu Arg Ser Glu Asn  Gly Asp Ser 
    1070                 1075                 1080             


Trp Lys  Glu His Phe Cys Asp  Tyr Xaa Glu Asp Glu  Leu Asn Glu 
    1085                 1090                 1095             


Ile Leu  Asn Gly Met Asp Glu  Val Leu Asp Ser Pro  Glu Asp Leu 
    1100                 1105                 1110             


Glu 
    


<210> 2307
<211> 1611
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1128)..(1128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1190)..(1190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1270)..(1270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1306)..(1306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1364)..(1364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1369)..(1369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1392)..(1392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1395)..(1395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1397)..(1397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1431)..(1431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1435)..(1436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1485)..(1485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1525)..(1525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1554)..(1554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1559)..(1559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1570)..(1570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1600)..(1600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1603)..(1603)
<223> Selenocysteine

<400> 2307
Met Xaa Xaa Met Leu Gln Lys Ser Asp Ser Asn Ala Ser Phe Leu Arg 
1               5                   10                  15      


Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val Glu Tyr Leu Lys Gly 
            20                  25                  30          


Gly Ile Asp Ile Asn Xaa Cys Asn Gln Asn Gly Leu Asn Ala Leu His 
        35                  40                  45              


Leu Ala Ala Lys Glu Gly His Val Gly Leu Val Gln Glu Leu Leu Gly 
    50                  55                  60                  


Arg Gly Ser Ser Val Asp Ser Ala Xaa Lys Lys Gly Asn Xaa Ala Leu 
65                  70                  75                  80  


His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val Val Lys Val Leu Val 
                85                  90                  95      


Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln Asn Gly Phe Xaa Pro 
            100                 105                 110         


Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp Val Val Lys Tyr Leu 
        115                 120                 125             


Leu Glu Asn Gly Ala Asn Gln Ser Xaa Ala Xaa Glu Asp Gly Phe Xaa 
    130                 135                 140                 


Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn Gln Ala Val Ala Ile 
145                 150                 155                 160 


Leu Leu Glu Asn Asp Xaa Lys Gly Lys Val Arg Leu Pro Ala Leu His 
                165                 170                 175     


Ile Ala Ala Arg Lys Asp Asp Xaa Lys Ser Ala Ala Leu Leu Leu Gln 
            180                 185                 190         


Asn Asp His Asn Ala Asp Val Gln Ser Lys Met Met Val Asn Arg Xaa 
        195                 200                 205             


Xaa Glu Ser Gly Phe Xaa Pro Leu His Ile Ala Ala His Tyr Gly Asn 
    210                 215                 220                 


Val Asn Val Ala Xaa Leu Leu Leu Asn Arg Gly Ala Ala Val Asp Phe 
225                 230                 235                 240 


Xaa Ala Arg Asn Gly Ile Xaa Pro Leu His Val Ala Ser Lys Arg Gly 
                245                 250                 255     


Asn Xaa Asn Met Val Lys Leu Leu Leu Asp Arg Gly Gly Gln Ile Asp 
            260                 265                 270         


Ala Lys Xaa Arg Asp Gly Leu Xaa Pro Leu His Cys Ala Ala Arg Ser 
        275                 280                 285             


Gly His Asp Gln Val Val Glu Leu Leu Leu Glu Arg Gly Ala Pro Leu 
    290                 295                 300                 


Leu Ala Arg Xaa Lys Asn Gly Leu Ser Pro Leu His Met Ala Ala Gln 
305                 310                 315                 320 


Gly Asp His Val Glu Cys Val Lys His Leu Leu Gln His Lys Ala Pro 
                325                 330                 335     


Val Asp Asp Val Xaa Leu Asp Tyr Leu Xaa Ala Leu His Val Ala Ala 
            340                 345                 350         


His Cys Gly His Tyr Arg Val Xaa Lys Leu Leu Leu Asp Lys Arg Ala 
        355                 360                 365             


Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Xaa Pro Leu His Ile Ala 
    370                 375                 380                 


Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu Leu Val Lys Tyr Gly 
385                 390                 395                 400 


Ala Ser Ile Gln Ala Ile Xaa Glu Ser Gly Leu Xaa Pro Ile His Val 
                405                 410                 415     


Ala Ala Phe Met Gly His Leu Asn Ile Val Leu Leu Leu Leu Gln Asn 
            420                 425                 430         


Gly Ala Ser Pro Asp Val Xaa Asn Ile Arg Gly Glu Xaa Ala Leu His 
        435                 440                 445             


Met Ala Ala Arg Ala Gly Gln Val Glu Val Val Arg Cys Leu Leu Arg 
    450                 455                 460                 


Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu Glu Gln Xaa Pro Leu 
465                 470                 475                 480 


His Ile Ala Ser Arg Leu Gly Lys Xaa Glu Ile Val Gln Leu Leu Leu 
                485                 490                 495     


Gln His Met Ala His Pro Asp Ala Ala Xaa Xaa Asn Gly Tyr Xaa Pro 
            500                 505                 510         


Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp Val Ala Ser Val Leu 
        515                 520                 525             


Leu Glu Ala Gly Ala Ala His Ser Leu Ala Xaa Lys Lys Gly Phe Xaa 
    530                 535                 540                 


Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu Asp Val Ala Lys Leu 
545                 550                 555                 560 


Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala Gly Lys Asn Gly Tyr 
                565                 570                 575     


Xaa Pro Leu His Ile Ala Ala Lys Lys Asn Gln Met Gln Ile Ala Ser 
            580                 585                 590         


Xaa Leu Leu Asn Tyr Gly Ala Glu Xaa Asn Ile Val Xaa Lys Gln Gly 
        595                 600                 605             


Val Xaa Pro Leu His Leu Ala Ser Gln Glu Gly His Xaa Asp Met Val 
    610                 615                 620                 


Xaa Leu Leu Leu Asp Lys Gly Ala Asn Ile His Met Ser Xaa Lys Ser 
625                 630                 635                 640 


Gly Leu Xaa Ser Leu His Leu Ala Ala Gln Glu Asp Lys Val Asn Val 
                645                 650                 655     


Ala Asp Ile Leu Xaa Lys His Gly Ala Asp Gln Asp Ala His Xaa Lys 
            660                 665                 670         


Leu Gly Tyr Xaa Pro Leu Ile Val Ala Cys His Tyr Gly Asn Val Lys 
        675                 680                 685             


Met Val Asn Phe Leu Leu Lys Gln Gly Ala Asn Val Asn Ala Lys Xaa 
    690                 695                 700                 


Lys Asn Gly Tyr Xaa Pro Leu His Gln Ala Ala Gln Gln Gly His Xaa 
705                 710                 715                 720 


His Ile Ile Asn Val Leu Leu Gln His Gly Ala Lys Pro Asn Ala Xaa 
                725                 730                 735     


Xaa Ala Asn Gly Asn Xaa Ala Leu Ala Ile Ala Lys Arg Leu Gly Tyr 
            740                 745                 750         


Ile Ser Val Val Asp Xaa Leu Lys Val Val Xaa Glu Glu Val Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Ile Xaa Glu Lys His Lys Leu Asn Val Pro Glu Xaa 
    770                 775                 780                 


Met Xaa Glu Val Leu Asp Val Ser Asp Glu Glu Gly Asp Asp Xaa Met 
785                 790                 795                 800 


Xaa Gly Asp Gly Gly Glu Tyr Leu Arg Pro Glu Asp Leu Lys Glu Leu 
                805                 810                 815     


Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe Leu Asp Gly Met Asn Tyr 
            820                 825                 830         


Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser Asp Ser Leu Arg Ser Phe 
        835                 840                 845             


Ser Ser Asp Arg Ser His Xaa Leu Ser His Ala Ser Tyr Leu Arg Asp 
    850                 855                 860                 


Ser Ala Val Met Asp Asp Ser Val Val Ile Pro Ser His Gln Val Ser 
865                 870                 875                 880 


Xaa Leu Ala Lys Glu Ala Glu Arg Asn Ser Tyr Arg Leu Ser Trp Gly 
                885                 890                 895     


Xaa Glu Asn Leu Asp Asn Val Ala Leu Ser Ser Ser Pro Ile His Ser 
            900                 905                 910         


Gly Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ala Met Arg 
        915                 920                 925             


Gly Cys Arg His Asn Gly Leu Arg Ile Ile Ile Pro Pro Arg Lys Cys 
    930                 935                 940                 


Xaa Ala Pro Xaa Arg Val Xaa Cys Arg Leu Val Lys Arg His Arg Leu 
945                 950                 955                 960 


Ala Xaa Met Pro Pro Met Val Glu Gly Glu Gly Leu Ala Ser Arg Leu 
                965                 970                 975     


Ile Glu Val Gly Pro Ser Gly Ala Gln Phe Leu Gly Pro Val Ile Val 
            980                 985                 990         


Glu Ile Pro His Phe Ala Ala Leu  Arg Gly Lys Glu Arg  Glu Leu Val 
        995                 1000                 1005             


Val Leu  Arg Ser Glu Asn Gly  Asp Ser Trp Lys Glu  His Phe Cys 
    1010                 1015                 1020             


Asp Tyr  Xaa Glu Asp Glu Leu  Asn Glu Ile Leu Asn  Gly Met Asp 
    1025                 1030                 1035             


Glu Val  Leu Asp Ser Pro Glu  Asp Leu Glu Lys Lys  Arg Ile Cys 
    1040                 1045                 1050             


Arg Ile  Ile Xaa Arg Asp Phe  Pro Gln Tyr Phe Ala  Val Val Ser 
    1055                 1060                 1065             


Arg Ile  Lys Gln Asp Ser Asn  Leu Ile Gly Pro Glu  Gly Gly Val 
    1070                 1075                 1080             


Leu Ser  Ser Xaa Val Val Pro  Gln Val Gln Ala Val  Phe Pro Glu 
    1085                 1090                 1095             


Gly Ala  Leu Xaa Lys Arg Ile  Arg Val Gly Leu Gln  Ala Gln Pro 
    1100                 1105                 1110             


Met His  Ser Glu Leu Val Lys  Lys Ile Leu Gly Asn  Lys Ala Xaa 
    1115                 1120                 1125             


Phe Ser  Pro Ile Val Xaa Leu  Glu Pro Arg Arg Arg  Lys Phe His 
    1130                 1135                 1140             


Lys Pro  Ile Xaa Met Xaa Ile  Pro Val Pro Lys Ala  Ser Ser Asp 
    1145                 1150                 1155             


Val Met  Leu Asn Gly Phe Gly  Gly Asp Ala Pro Xaa  Leu Arg Leu 
    1160                 1165                 1170             


Leu Cys  Ser Ile Xaa Gly Gly  Xaa Xaa Pro Ala Gln  Trp Glu Asp 
    1175                 1180                 1185             


Ile Xaa  Gly Xaa Xaa Pro Leu  Xaa Phe Val Asn Glu  Cys Val Ser 
    1190                 1195                 1200             


Phe Xaa  Xaa Asn Val Ser Ala  Arg Phe Trp Leu Ile  Asp Cys Arg 
    1205                 1210                 1215             


Gln Ile  Gln Glu Ser Val Xaa  Phe Ala Ser Gln Val  Tyr Arg Glu 
    1220                 1225                 1230             


Ile Ile  Cys Val Pro Tyr Met  Ala Lys Phe Val Val  Phe Ala Lys 
    1235                 1240                 1245             


Ser His  Asp Pro Ile Glu Ala  Arg Leu Arg Cys Phe  Cys Met Xaa 
    1250                 1255                 1260             


Asp Asp  Lys Val Asp Lys Xaa  Leu Glu Gln Gln Glu  Asn Phe Ala 
    1265                 1270                 1275             


Glu Val  Ala Arg Ser Arg Asp  Val Glu Val Leu Glu  Gly Lys Pro 
    1280                 1285                 1290             


Ile Tyr  Val Asp Cys Phe Gly  Asn Leu Val Pro Leu  Xaa Lys Ser 
    1295                 1300                 1305             


Gly Gln  His His Ile Phe Ser  Phe Phe Ala Phe Lys  Glu Asn Arg 
    1310                 1315                 1320             


Leu Pro  Leu Phe Val Lys Val  Arg Asp Xaa Xaa Gln  Glu Pro Cys 
    1325                 1330                 1335             


Gly Arg  Leu Ser Phe Met Lys  Glu Pro Lys Ser Xaa  Arg Gly Leu 
    1340                 1345                 1350             


Val His  Gln Ala Ile Cys Asn  Leu Asn Ile Xaa Leu  Pro Ile Tyr 
    1355                 1360                 1365             


Xaa Lys  Glu Ser Glu Ser Asp  Gln Glu Gln Glu Glu  Glu Ile Asp 
    1370                 1375                 1380             


Met Xaa  Ser Glu Lys Asn Asp  Glu Xaa Glu Ser Xaa  Glu Xaa Ser 
    1385                 1390                 1395             


Val Leu  Lys Ser His Leu Val  Asn Glu Val Pro Val  Leu Ala Ser 
    1400                 1405                 1410             


Pro Asp  Leu Leu Ser Glu Val  Ser Glu Met Lys Gln  Asp Leu Ile 
    1415                 1420                 1425             


Lys Met  Xaa Ala Ile Leu Xaa  Xaa Asp Val Ser Asp  Lys Ala Gly 
    1430                 1435                 1440             


Ser Ile  Lys Val Lys Glu Leu  Val Lys Ala Ala Glu  Glu Glu Pro 
    1445                 1450                 1455             


Gly Glu  Pro Phe Glu Ile Val  Glu Arg Val Lys Glu  Asp Leu Glu 
    1460                 1465                 1470             


Lys Val  Asn Glu Ile Leu Arg  Ser Gly Xaa Cys Xaa  Arg Asp Glu 
    1475                 1480                 1485             


Ser Ser  Val Gln Ser Ser Arg  Ser Glu Arg Gly Leu  Val Glu Glu 
    1490                 1495                 1500             


Glu Trp  Val Ile Val Ser Asp  Glu Glu Ile Glu Glu  Ala Arg Gln 
    1505                 1510                 1515             


Lys Ala  Pro Leu Glu Ile Xaa  Glu Tyr Pro Cys Val  Glu Val Arg 
    1520                 1525                 1530             


Ile Asp  Lys Glu Ile Lys Gly  Lys Val Glu Lys Asp  Ser Xaa Gly 
    1535                 1540                 1545             


Leu Val  Asn Tyr Leu Xaa Asp  Asp Leu Asn Xaa Cys  Val Pro Leu 
    1550                 1555                 1560             


Pro Lys  Glu Gln Leu Gln Xaa  Val Gln Asp Lys Ala  Gly Lys Lys 
    1565                 1570                 1575             


Cys Glu  Ala Leu Ala Val Gly  Arg Ser Ser Glu Lys  Glu Gly Lys 
    1580                 1585                 1590             


Asp Ile  Pro Pro Asp Glu Xaa  Gln Ser Xaa Gln Lys  Gln His Lys 
    1595                 1600                 1605             


Pro Ser  Leu 
    1610     


<210> 2308
<211> 1863
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (996)..(996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1007)..(1007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1206)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1248)..(1248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1268)..(1268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1270)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1384)..(1384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1411)..(1412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1428)..(1428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1442)..(1442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1447)..(1447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1463)..(1463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1491)..(1491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1500)..(1500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1535)..(1535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1537)..(1537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1544)..(1544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1557)..(1557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1559)..(1559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1576)..(1576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1578)..(1578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1611)..(1611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1629)..(1629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1637)..(1637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1644)..(1644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1650)..(1650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1681)..(1682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1685)..(1685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1687)..(1687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1690)..(1690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1703)..(1703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1709)..(1709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1720)..(1720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1722)..(1722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1750)..(1750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1764)..(1764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1789)..(1789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1800)..(1800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1806)..(1806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1819)..(1819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1855)..(1855)
<223> Selenocysteine

<400> 2308
Met Xaa Xaa Met Leu Gln Lys Ser Asp Ser Asn Ala Ser Phe Leu Arg 
1               5                   10                  15      


Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val Glu Tyr Leu Lys Gly 
            20                  25                  30          


Gly Ile Asp Ile Asn Xaa Cys Asn Gln Asn Gly Leu Asn Ala Leu His 
        35                  40                  45              


Leu Ala Ala Lys Glu Gly His Val Gly Leu Val Gln Glu Leu Leu Gly 
    50                  55                  60                  


Arg Gly Ser Ser Val Asp Ser Ala Xaa Lys Lys Gly Asn Xaa Ala Leu 
65                  70                  75                  80  


His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val Val Lys Val Leu Val 
                85                  90                  95      


Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln Asn Gly Phe Xaa Pro 
            100                 105                 110         


Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp Val Val Lys Tyr Leu 
        115                 120                 125             


Leu Glu Asn Gly Ala Asn Gln Ser Xaa Ala Xaa Glu Asp Gly Phe Xaa 
    130                 135                 140                 


Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn Gln Ala Val Ala Ile 
145                 150                 155                 160 


Leu Leu Glu Asn Asp Xaa Lys Gly Lys Val Arg Leu Pro Ala Leu His 
                165                 170                 175     


Ile Ala Ala Arg Lys Asp Asp Xaa Lys Ser Ala Ala Leu Leu Leu Gln 
            180                 185                 190         


Asn Asp His Asn Ala Asp Val Gln Ser Lys Met Met Val Asn Arg Xaa 
        195                 200                 205             


Xaa Glu Ser Gly Phe Xaa Pro Leu His Ile Ala Ala His Tyr Gly Asn 
    210                 215                 220                 


Val Asn Val Ala Xaa Leu Leu Leu Asn Arg Gly Ala Ala Val Asp Phe 
225                 230                 235                 240 


Xaa Ala Arg Asn Gly Ile Xaa Pro Leu His Val Ala Ser Lys Arg Gly 
                245                 250                 255     


Asn Xaa Asn Met Val Lys Leu Leu Leu Asp Arg Gly Gly Gln Ile Asp 
            260                 265                 270         


Ala Lys Xaa Arg Asp Gly Leu Xaa Pro Leu His Cys Ala Ala Arg Ser 
        275                 280                 285             


Gly His Asp Gln Val Val Glu Leu Leu Leu Glu Arg Gly Ala Pro Leu 
    290                 295                 300                 


Leu Ala Arg Xaa Lys Asn Gly Leu Ser Pro Leu His Met Ala Ala Gln 
305                 310                 315                 320 


Gly Asp His Val Glu Cys Val Lys His Leu Leu Gln His Lys Ala Pro 
                325                 330                 335     


Val Asp Asp Val Xaa Leu Asp Tyr Leu Xaa Ala Leu His Val Ala Ala 
            340                 345                 350         


His Cys Gly His Tyr Arg Val Xaa Lys Leu Leu Leu Asp Lys Arg Ala 
        355                 360                 365             


Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Xaa Pro Leu His Ile Ala 
    370                 375                 380                 


Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu Leu Val Lys Tyr Gly 
385                 390                 395                 400 


Ala Ser Ile Gln Ala Ile Xaa Glu Ser Gly Leu Xaa Pro Ile His Val 
                405                 410                 415     


Ala Ala Phe Met Gly His Leu Asn Ile Val Leu Leu Leu Leu Gln Asn 
            420                 425                 430         


Gly Ala Ser Pro Asp Val Xaa Asn Ile Arg Gly Glu Xaa Ala Leu His 
        435                 440                 445             


Met Ala Ala Arg Ala Gly Gln Val Glu Val Val Arg Cys Leu Leu Arg 
    450                 455                 460                 


Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu Glu Gln Xaa Pro Leu 
465                 470                 475                 480 


His Ile Ala Ser Arg Leu Gly Lys Xaa Glu Ile Val Gln Leu Leu Leu 
                485                 490                 495     


Gln His Met Ala His Pro Asp Ala Ala Xaa Xaa Asn Gly Tyr Xaa Pro 
            500                 505                 510         


Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp Val Ala Ser Val Leu 
        515                 520                 525             


Leu Glu Ala Gly Ala Ala His Ser Leu Ala Xaa Lys Lys Gly Phe Xaa 
    530                 535                 540                 


Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu Asp Val Ala Lys Leu 
545                 550                 555                 560 


Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala Gly Lys Asn Gly Leu 
                565                 570                 575     


Xaa Pro Leu His Val Ala Ala His Tyr Asp Asn Gln Lys Val Ala Leu 
            580                 585                 590         


Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala Xaa Ala Lys Asn Gly 
        595                 600                 605             


Tyr Xaa Pro Leu His Ile Ala Ala Lys Lys Asn Gln Met Gln Ile Ala 
    610                 615                 620                 


Ser Xaa Leu Leu Asn Tyr Gly Ala Glu Xaa Asn Ile Val Xaa Lys Gln 
625                 630                 635                 640 


Gly Val Xaa Pro Leu His Leu Ala Ser Gln Glu Gly His Xaa Asp Met 
                645                 650                 655     


Val Xaa Leu Leu Leu Asp Lys Gly Ala Asn Ile His Met Ser Xaa Lys 
            660                 665                 670         


Ser Gly Leu Xaa Ser Leu His Leu Ala Ala Gln Glu Asp Lys Val Asn 
        675                 680                 685             


Val Ala Asp Ile Leu Xaa Lys His Gly Ala Asp Gln Asp Ala His Xaa 
    690                 695                 700                 


Lys Leu Gly Tyr Xaa Pro Leu Ile Val Ala Cys His Tyr Gly Asn Val 
705                 710                 715                 720 


Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala Asn Val Asn Ala Lys 
                725                 730                 735     


Xaa Lys Asn Gly Tyr Xaa Pro Leu His Gln Ala Ala Gln Gln Gly His 
            740                 745                 750         


Xaa His Ile Ile Asn Val Leu Leu Gln His Gly Ala Lys Pro Asn Ala 
        755                 760                 765             


Xaa Xaa Ala Asn Gly Asn Xaa Ala Leu Ala Ile Ala Lys Arg Leu Gly 
    770                 775                 780                 


Tyr Ile Ser Val Val Asp Xaa Leu Lys Val Val Xaa Glu Glu Val Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Ile Xaa Glu Lys His Lys Leu Asn Val Pro Glu 
                805                 810                 815     


Xaa Met Xaa Glu Val Leu Asp Val Ser Asp Glu Glu Gly Asp Asp Xaa 
            820                 825                 830         


Met Xaa Gly Asp Gly Gly Glu Tyr Leu Arg Pro Glu Asp Leu Lys Glu 
        835                 840                 845             


Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe Leu Asp Gly Met Asn 
    850                 855                 860                 


Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser Asp Ser Leu Arg Ser 
865                 870                 875                 880 


Phe Ser Ser Asp Arg Ser His Xaa Leu Ser His Ala Ser Tyr Leu Arg 
                885                 890                 895     


Asp Ser Ala Val Met Asp Asp Ser Val Val Ile Pro Ser His Gln Val 
            900                 905                 910         


Ser Xaa Leu Ala Lys Glu Ala Glu Arg Asn Ser Tyr Arg Leu Ser Trp 
        915                 920                 925             


Gly Xaa Glu Asn Leu Asp Asn Val Ala Leu Ser Ser Ser Pro Ile His 
    930                 935                 940                 


Ser Gly Arg Ala Ser Pro Cys Leu Glu Arg Asp Asn Ser Ser Phe Leu 
945                 950                 955                 960 


Val Ser Phe Met Val Asp Ala Arg Gly Gly Ala Met Arg Gly Cys Arg 
                965                 970                 975     


His Asn Gly Leu Arg Ile Ile Ile Pro Pro Arg Lys Cys Xaa Ala Pro 
            980                 985                 990         


Xaa Arg Val Xaa Cys Arg Leu Val  Lys Arg His Arg Leu  Ala Xaa Met 
        995                 1000                 1005             


Pro Pro  Met Val Glu Gly Glu  Gly Leu Ala Ser Arg  Leu Ile Glu 
    1010                 1015                 1020             


Val Gly  Pro Ser Gly Ala Gln  Phe Leu Gly Lys Leu  His Leu Pro 
    1025                 1030                 1035             


Xaa Ala  Pro Pro Pro Leu Asn  Glu Gly Glu Ser Leu  Val Ser Arg 
    1040                 1045                 1050             


Ile Leu  Gln Leu Gly Pro Pro  Gly Xaa Lys Phe Leu  Gly Pro Val 
    1055                 1060                 1065             


Ile Val  Glu Ile Pro His Phe  Ala Ala Leu Arg Gly  Lys Glu Arg 
    1070                 1075                 1080             


Glu Leu  Val Val Leu Arg Ser  Glu Asn Gly Asp Ser  Trp Lys Glu 
    1085                 1090                 1095             


His Phe  Cys Asp Tyr Xaa Glu  Asp Glu Leu Asn Glu  Ile Leu Asn 
    1100                 1105                 1110             


Gly Met  Asp Glu Val Leu Asp  Ser Pro Glu Asp Leu  Glu Lys Lys 
    1115                 1120                 1125             


Arg Ile  Cys Arg Ile Ile Xaa  Arg Asp Phe Pro Gln  Tyr Phe Ala 
    1130                 1135                 1140             


Val Val  Ser Arg Ile Lys Gln  Asp Ser Asn Leu Ile  Gly Pro Glu 
    1145                 1150                 1155             


Gly Gly  Val Leu Ser Ser Xaa  Val Val Pro Gln Val  Gln Ala Val 
    1160                 1165                 1170             


Phe Pro  Glu Gly Ala Leu Xaa  Lys Arg Ile Arg Val  Gly Leu Gln 
    1175                 1180                 1185             


Ala Gln  Pro Met His Ser Glu  Leu Val Lys Lys Ile  Leu Gly Asn 
    1190                 1195                 1200             


Lys Ala  Xaa Phe Ser Pro Ile  Val Xaa Leu Glu Pro  Arg Arg Arg 
    1205                 1210                 1215             


Lys Phe  His Lys Pro Ile Xaa  Met Xaa Ile Pro Val  Pro Lys Ala 
    1220                 1225                 1230             


Ser Ser  Asp Val Met Leu Asn  Gly Phe Gly Gly Asp  Ala Pro Xaa 
    1235                 1240                 1245             


Leu Arg  Leu Leu Cys Ser Ile  Xaa Gly Gly Xaa Xaa  Pro Ala Gln 
    1250                 1255                 1260             


Trp Glu  Asp Ile Xaa Gly Xaa  Xaa Pro Leu Xaa Phe  Val Asn Glu 
    1265                 1270                 1275             


Cys Val  Ser Phe Xaa Xaa Asn  Val Ser Ala Arg Phe  Trp Leu Ile 
    1280                 1285                 1290             


Asp Cys  Arg Gln Ile Gln Glu  Ser Val Xaa Phe Ala  Ser Gln Val 
    1295                 1300                 1305             


Tyr Arg  Glu Ile Ile Cys Val  Pro Tyr Met Ala Lys  Phe Val Val 
    1310                 1315                 1320             


Phe Ala  Lys Ser His Asp Pro  Ile Glu Ala Arg Leu  Arg Cys Phe 
    1325                 1330                 1335             


Cys Met  Xaa Asp Asp Lys Val  Asp Lys Xaa Leu Glu  Gln Gln Glu 
    1340                 1345                 1350             


Asn Phe  Ala Glu Val Ala Arg  Ser Arg Asp Val Glu  Val Leu Glu 
    1355                 1360                 1365             


Gly Lys  Pro Ile Tyr Val Asp  Cys Phe Gly Asn Leu  Val Pro Leu 
    1370                 1375                 1380             


Xaa Lys  Ser Gly Gln His His  Ile Phe Ser Phe Phe  Ala Phe Lys 
    1385                 1390                 1395             


Glu Asn  Arg Leu Pro Leu Phe  Val Lys Val Arg Asp  Xaa Xaa Gln 
    1400                 1405                 1410             


Glu Pro  Cys Gly Arg Leu Ser  Phe Met Lys Glu Pro  Lys Ser Xaa 
    1415                 1420                 1425             


Arg Gly  Leu Val His Gln Ala  Ile Cys Asn Leu Asn  Ile Xaa Leu 
    1430                 1435                 1440             


Pro Ile  Tyr Xaa Lys Glu Ser  Glu Ser Asp Gln Glu  Gln Glu Glu 
    1445                 1450                 1455             


Glu Ile  Asp Met Xaa Ser Glu  Lys Asn Pro Gln Asp  Glu Gln Glu 
    1460                 1465                 1470             


Arg Ile  Glu Glu Arg Leu Ala  Tyr Ile Ala Asp His  Leu Gly Phe 
    1475                 1480                 1485             


Ser Trp  Xaa Glu Leu Ala Arg  Glu Leu Asp Phe Xaa  Glu Glu Gln 
    1490                 1495                 1500             


Ile His  Gln Ile Arg Ile Glu  Asn Pro Asn Ser Leu  Gln Asp Gln 
    1505                 1510                 1515             


Ser His  Ala Leu Leu Lys Tyr  Trp Leu Glu Arg Asp  Gly Lys His 
    1520                 1525                 1530             


Ala Xaa  Asp Xaa Asn Leu Val  Glu Cys Leu Xaa Lys  Ile Asn Arg 
    1535                 1540                 1545             


Met Asp  Ile Val His Leu Met  Glu Xaa Asn Xaa Glu  Pro Leu Gln 
    1550                 1555                 1560             


Glu Arg  Ile Ser His Ser Tyr  Ala Glu Ile Glu Gln  Xaa Ile Xaa 
    1565                 1570                 1575             


Leu Asp  His Ser Glu Gly Phe  Ser Val Leu Gln Glu  Glu Leu Cys 
    1580                 1585                 1590             


Xaa Ala  Gln His Lys Gln Lys  Glu Glu Gln Ala Val  Ser Lys Glu 
    1595                 1600                 1605             


Ser Glu  Xaa Cys Asp His Pro  Pro Ile Val Ser Glu  Glu Asp Ile 
    1610                 1615                 1620             


Ser Val  Gly Tyr Ser Xaa Phe  Gln Asp Gly Val Pro  Lys Xaa Glu 
    1625                 1630                 1635             


Gly Asp  Ser Ser Ala Xaa Ala  Leu Phe Pro Gln Xaa  His Lys Glu 
    1640                 1645                 1650             


Gln Val  Gln Gln Asp Phe Ser  Gly Lys Met Gln Asp  Leu Pro Glu 
    1655                 1660                 1665             


Glu Ser  Ser Leu Glu Tyr Gln  Gln Glu Tyr Phe Val  Xaa Xaa Pro 
    1670                 1675                 1680             


Gly Xaa  Glu Xaa Ser Glu Xaa  Gln Lys Ala Met Ile  Val Pro Ser 
    1685                 1690                 1695             


Ser Pro  Ser Lys Xaa Pro Glu  Glu Val Ser Xaa Pro  Ala Glu Glu 
    1700                 1705                 1710             


Glu Lys  Leu Tyr Leu Gln Xaa  Pro Xaa Ser Ser Glu  Arg Gly Gly 
    1715                 1720                 1725             


Ser Pro  Ile Ile Gln Glu Pro  Glu Glu Pro Ser Glu  His Arg Glu 
    1730                 1735                 1740             


Glu Ser  Ser Pro Arg Lys Xaa  Ser Leu Val Ile Val  Glu Ser Ala 
    1745                 1750                 1755             


Asp Asn  Gln Pro Glu Xaa Cys  Glu Arg Leu Asp Glu  Asp Ala Ala 
    1760                 1765                 1770             


Phe Glu  Lys Gly Asp Asp Met  Pro Glu Ile Pro Pro  Glu Xaa Val 
    1775                 1780                 1785             


Xaa Glu  Glu Glu Tyr Ile Asp  Glu His Gly His Xaa  Val Val Lys 
    1790                 1795                 1800             


Lys Val  Xaa Arg Lys Ile Ile  Arg Arg Tyr Val Ser  Ser Glu Gly 
    1805                 1810                 1815             


Xaa Glu  Lys Glu Glu Ile Met  Val Gln Gly Met Pro  Gln Glu Pro 
    1820                 1825                 1830             


Val Asn  Ile Glu Glu Gly Asp  Gly Tyr Ser Lys Val  Ile Lys Arg 
    1835                 1840                 1845             


Val Val  Leu Lys Ser Asp Xaa  Glu Gln Ser Glu Asp  Asn Asn Glu 
    1850                 1855                 1860             


<210> 2309
<211> 1028
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<400> 2309
Gln Asp Ile Lys Met Glu Ser Gln Gln Glu Ser Xaa Leu Trp Glu Met 
1               5                   10                  15      


Gln Ser Asp Ser Val Ser Ser Ser Phe Glu Pro Xaa Met Ser Ala Xaa 
            20                  25                  30          


Xaa Xaa Val Val Gly Glu Gln Ile Ser Lys Val Ile Ile Xaa Lys Xaa 
        35                  40                  45              


Asp Val Asp Ser Asp Ser Trp Ser Glu Ile Arg Glu Asp Asp Glu Ala 
    50                  55                  60                  


Phe Glu Ala Arg Val Lys Glu Glu Glu Gln Lys Ile Phe Gly Leu Met 
65                  70                  75                  80  


Val Asp Arg Gln Ser Gln Gly Xaa Xaa Pro Asp Xaa Xaa Pro Ala Arg 
                85                  90                  95      


Xaa Pro Xaa Glu Glu Gly Xaa Pro Xaa Ser Glu Gln Asn Pro Phe Leu 
            100                 105                 110         


Phe Gln Glu Gly Lys Leu Phe Glu Met Xaa Arg Ser Gly Ala Ile Asp 
        115                 120                 125             


Met Xaa Lys Arg Ser Tyr Ala Asp Glu Ser Phe His Phe Phe Gln Ile 
    130                 135                 140                 


Gly Gln Glu Ser Arg Glu Glu Xaa Leu Ser Glu Asp Val Lys Glu Gly 
145                 150                 155                 160 


Ala Xaa Gly Ala Asp Pro Leu Pro Leu Glu Xaa Ser Ala Glu Ser Leu 
                165                 170                 175     


Ala Leu Ser Glu Ser Lys Glu Xaa Val Asp Asp Glu Ala Asp Leu Leu 
            180                 185                 190         


Pro Asp Asp Val Ser Glu Glu Val Glu Glu Ile Pro Ala Ser Asp Ala 
        195                 200                 205             


Gln Leu Asn Ser Gln Met Gly Ile Ser Ala Ser Xaa Glu Xaa Pro Xaa 
    210                 215                 220                 


Lys Glu Ala Val Ser Val Gly Xaa Lys Asp Leu Pro Xaa Val Gln Xaa 
225                 230                 235                 240 


Gly Asp Ile Pro Pro Leu Ser Gly Val Lys Gln Ile Ser Cys Pro Asp 
                245                 250                 255     


Ser Ser Glu Pro Ala Val Gln Val Gln Leu Asp Phe Ser Xaa Leu Xaa 
            260                 265                 270         


Arg Ser Val Tyr Ser Asp Arg Gly Asp Asp Ser Pro Asp Ser Ser Pro 
        275                 280                 285             


Glu Glu Gln Lys Ser Val Ile Glu Ile Pro Xaa Ala Pro Met Glu Asn 
    290                 295                 300                 


Val Pro Phe Xaa Glu Ser Lys Ser Lys Ile Pro Val Arg Xaa Met Pro 
305                 310                 315                 320 


Xaa Ser Xaa Pro Ala Pro Pro Ser Ala Glu Tyr Glu Ser Ser Val Ser 
                325                 330                 335     


Glu Asp Phe Leu Ser Ser Val Asp Glu Glu Asn Lys Ala Asp Glu Ala 
            340                 345                 350         


Lys Pro Lys Ser Lys Leu Pro Val Lys Val Pro Leu Gln Arg Val Glu 
        355                 360                 365             


Gln Gln Leu Ser Asp Leu Asp Xaa Ser Val Gln Lys Xaa Val Ala Pro 
    370                 375                 380                 


Gln Gly Gln Asp Met Ala Ser Ile Ala Pro Asp Asn Arg Ser Lys Ser 
385                 390                 395                 400 


Glu Ser Asp Ala Ser Ser Leu Asp Ser Lys Xaa Lys Cys Pro Val Lys 
                405                 410                 415     


Xaa Arg Ser Tyr Xaa Glu Xaa Glu Xaa Glu Ser Arg Glu Arg Ala Glu 
            420                 425                 430         


Glu Leu Glu Leu Glu Ser Glu Glu Gly Ala Xaa Arg Pro Lys Ile Leu 
        435                 440                 445             


Xaa Ser Arg Leu Pro Val Lys Ser Arg Ser Xaa Xaa Ser Ser Cys Arg 
    450                 455                 460                 


Gly Gly Xaa Ser Pro Xaa Lys Glu Ser Lys Glu His Phe Phe Asp Leu 
465                 470                 475                 480 


Tyr Arg Asn Ser Ile Glu Phe Phe Glu Glu Ile Ser Asp Glu Ala Ser 
                485                 490                 495     


Lys Leu Val Asp Arg Leu Xaa Gln Ser Glu Arg Glu Gln Glu Ile Val 
            500                 505                 510         


Ser Asp Asp Glu Ser Ser Ser Ala Leu Glu Val Ser Val Ile Glu Asn 
        515                 520                 525             


Leu Pro Pro Val Glu Xaa Glu His Ser Val Pro Glu Asp Ile Phe Asp 
    530                 535                 540                 


Xaa Arg Pro Ile Trp Asp Glu Ser Ile Glu Xaa Leu Ile Glu Arg Ile 
545                 550                 555                 560 


Pro Asp Glu Asn Gly His Asp His Ala Glu Asp Pro Gln Asp Glu Gln 
                565                 570                 575     


Glu Arg Ile Glu Glu Arg Leu Ala Tyr Ile Ala Asp His Leu Gly Phe 
            580                 585                 590         


Ser Trp Xaa Glu Leu Ala Arg Glu Leu Asp Phe Xaa Glu Glu Gln Ile 
        595                 600                 605             


His Gln Ile Arg Ile Glu Asn Pro Asn Ser Leu Gln Asp Gln Ser His 
    610                 615                 620                 


Ala Leu Leu Lys Tyr Trp Leu Glu Arg Asp Gly Lys His Ala Xaa Asp 
625                 630                 635                 640 


Xaa Asn Leu Val Glu Cys Leu Xaa Lys Ile Asn Arg Met Asp Ile Val 
                645                 650                 655     


His Leu Met Glu Xaa Asn Xaa Glu Pro Leu Gln Glu Arg Ile Ser His 
            660                 665                 670         


Ser Tyr Ala Glu Ile Glu Gln Xaa Ile Xaa Leu Asp His Ser Glu Gly 
        675                 680                 685             


Phe Ser Val Leu Gln Glu Glu Leu Cys Xaa Ala Gln His Lys Gln Lys 
    690                 695                 700                 


Glu Glu Gln Ala Val Ser Lys Glu Ser Glu Xaa Cys Asp His Pro Pro 
705                 710                 715                 720 


Ile Val Ser Glu Glu Asp Ile Ser Val Gly Tyr Ser Xaa Phe Gln Asp 
                725                 730                 735     


Gly Val Pro Lys Xaa Glu Gly Asp Ser Ser Ala Xaa Ala Leu Phe Pro 
            740                 745                 750         


Gln Xaa His Lys Glu Gln Val Gln Gln Asp Phe Ser Gly Lys Met Gln 
        755                 760                 765             


Asp Leu Pro Glu Glu Ser Ser Leu Glu Tyr Gln Gln Glu Tyr Phe Val 
    770                 775                 780                 


Xaa Xaa Pro Gly Xaa Glu Xaa Ser Glu Xaa Gln Lys Ala Met Ile Val 
785                 790                 795                 800 


Pro Ser Ser Pro Ser Lys Xaa Pro Glu Glu Val Ser Xaa Pro Ala Glu 
                805                 810                 815     


Glu Glu Lys Leu Tyr Leu Gln Xaa Pro Xaa Ser Ser Glu Arg Gly Gly 
            820                 825                 830         


Ser Pro Ile Ile Gln Glu Pro Glu Glu Pro Ser Glu His Arg Glu Glu 
        835                 840                 845             


Ser Ser Pro Arg Lys Xaa Ser Leu Val Ile Val Glu Ser Ala Asp Asn 
    850                 855                 860                 


Gln Pro Glu Xaa Cys Glu Arg Leu Asp Glu Asp Ala Ala Phe Glu Lys 
865                 870                 875                 880 


Gly Asp Asp Met Pro Glu Ile Pro Pro Glu Xaa Val Xaa Glu Glu Glu 
                885                 890                 895     


Tyr Ile Asp Glu His Gly His Xaa Val Val Lys Lys Val Xaa Arg Lys 
            900                 905                 910         


Ile Ile Arg Arg Tyr Val Ser Ser Glu Gly Xaa Glu Lys Glu Glu Ile 
        915                 920                 925             


Met Val Gln Gly Met Pro Gln Glu Pro Val Asn Ile Glu Glu Gly Asp 
    930                 935                 940                 


Gly Tyr Ser Lys Val Ile Lys Arg Val Val Leu Lys Ser Asp Xaa Glu 
945                 950                 955                 960 


Gln Ser Glu Val Xaa Leu Cys Glu Pro Ser Ile Leu Ser Ser Xaa Ser 
                965                 970                 975     


Gln Phe Gln Ala Glu Pro Val Glu Gly Arg Arg Val Ser Lys Val Val 
            980                 985                 990         


Lys Xaa Xaa Val Val Leu Gly Glu  Arg Met Glu Lys His  Leu Gly Asp 
        995                 1000                 1005             


Ser Ser  Leu Ala Xaa Asp Leu  Pro Ser Ala Lys Asp  Asp Phe Glu 
    1010                 1015                 1020             


Glu Asp  Asn Asn Glu 
    1025             


<210> 2310
<211> 1195
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1145)..(1145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<400> 2310
Ser Asp Ser Asn Ala Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu 
1               5                   10                  15      


Asp Lys Val Val Glu Tyr Leu Lys Gly Gly Ile Asp Ile Asn Xaa Cys 
            20                  25                  30          


Asn Gln Asn Gly Leu Asn Ala Leu His Leu Ala Ala Lys Glu Gly His 
        35                  40                  45              


Val Gly Leu Val Gln Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser 
    50                  55                  60                  


Ala Xaa Lys Lys Gly Asn Xaa Ala Leu His Ile Ala Ser Leu Ala Gly 
65                  70                  75                  80  


Gln Ala Glu Val Val Lys Val Leu Val Lys Glu Gly Ala Asn Ile Asn 
                85                  90                  95      


Ala Gln Ser Gln Asn Gly Phe Xaa Pro Leu Tyr Met Ala Ala Gln Glu 
            100                 105                 110         


Asn His Ile Asp Val Val Lys Tyr Leu Leu Glu Asn Gly Ala Asn Gln 
        115                 120                 125             


Ser Xaa Ala Xaa Glu Asp Gly Phe Xaa Pro Leu Ala Val Ala Leu Gln 
    130                 135                 140                 


Gln Gly His Asn Gln Ala Val Ala Ile Leu Leu Glu Asn Asp Xaa Lys 
145                 150                 155                 160 


Gly Lys Val Arg Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp 
                165                 170                 175     


Xaa Lys Ser Ala Ala Leu Leu Leu Gln Asn Asp His Asn Ala Asp Val 
            180                 185                 190         


Gln Ser Lys Met Met Val Asn Arg Xaa Xaa Glu Ser Gly Phe Xaa Pro 
        195                 200                 205             


Leu His Ile Ala Ala His Tyr Gly Asn Val Asn Val Ala Xaa Leu Leu 
    210                 215                 220                 


Leu Asn Arg Gly Ala Ala Val Asp Phe Xaa Ala Arg Asn Gly Ile Xaa 
225                 230                 235                 240 


Pro Leu His Val Ala Ser Lys Arg Gly Asn Xaa Asn Met Val Lys Leu 
                245                 250                 255     


Leu Leu Asp Arg Gly Gly Gln Ile Asp Ala Lys Xaa Arg Asp Gly Leu 
            260                 265                 270         


Xaa Pro Leu His Cys Ala Ala Arg Ser Gly His Asp Gln Val Val Glu 
        275                 280                 285             


Leu Leu Leu Glu Arg Gly Ala Pro Leu Leu Ala Arg Xaa Lys Asn Gly 
    290                 295                 300                 


Leu Ser Pro Leu His Met Ala Ala Gln Gly Asp His Val Glu Cys Val 
305                 310                 315                 320 


Lys His Leu Leu Gln His Lys Ala Pro Val Asp Asp Val Xaa Leu Asp 
                325                 330                 335     


Tyr Leu Xaa Ala Leu His Val Ala Ala His Cys Gly His Tyr Arg Val 
            340                 345                 350         


Xaa Lys Leu Leu Leu Asp Lys Arg Ala Asn Pro Asn Ala Arg Ala Leu 
        355                 360                 365             


Asn Gly Phe Xaa Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys 
    370                 375                 380                 


Val Met Glu Leu Leu Val Lys Tyr Gly Ala Ser Ile Gln Ala Ile Xaa 
385                 390                 395                 400 


Glu Ser Gly Leu Xaa Pro Ile His Val Ala Ala Phe Met Gly His Leu 
                405                 410                 415     


Asn Ile Val Leu Leu Leu Leu Gln Asn Gly Ala Ser Pro Asp Val Xaa 
            420                 425                 430         


Asn Ile Arg Gly Glu Xaa Ala Leu His Met Ala Ala Arg Ala Gly Gln 
        435                 440                 445             


Val Glu Val Val Arg Cys Leu Leu Arg Asn Gly Ala Leu Val Asp Ala 
    450                 455                 460                 


Arg Ala Arg Glu Glu Gln Xaa Pro Leu His Ile Ala Ser Arg Leu Gly 
465                 470                 475                 480 


Lys Xaa Glu Ile Val Gln Leu Leu Leu Gln His Met Ala His Pro Asp 
                485                 490                 495     


Ala Ala Xaa Xaa Asn Gly Tyr Xaa Pro Leu His Ile Ser Ala Arg Glu 
            500                 505                 510         


Gly Gln Val Asp Val Ala Ser Val Leu Leu Glu Ala Gly Ala Ala His 
        515                 520                 525             


Ser Leu Ala Xaa Lys Lys Gly Phe Xaa Pro Leu His Val Ala Ala Lys 
    530                 535                 540                 


Tyr Gly Ser Leu Asp Val Ala Lys Leu Leu Leu Gln Arg Arg Ala Ala 
545                 550                 555                 560 


Ala Asp Ser Ala Gly Lys Asn Gly Leu Xaa Pro Leu His Val Ala Ala 
                565                 570                 575     


His Tyr Asp Asn Gln Lys Val Ala Leu Leu Leu Leu Glu Lys Gly Ala 
            580                 585                 590         


Ser Pro His Ala Xaa Ala Lys Asn Gly Tyr Xaa Pro Leu His Ile Ala 
        595                 600                 605             


Ala Lys Lys Asn Gln Met Gln Ile Ala Ser Xaa Leu Leu Asn Tyr Gly 
    610                 615                 620                 


Ala Glu Xaa Asn Ile Val Xaa Lys Gln Gly Val Xaa Pro Leu His Leu 
625                 630                 635                 640 


Ala Ser Gln Glu Gly His Xaa Asp Met Val Xaa Leu Leu Leu Asp Lys 
                645                 650                 655     


Gly Ala Asn Ile His Met Ser Xaa Lys Ser Gly Leu Xaa Ser Leu His 
            660                 665                 670         


Leu Ala Ala Gln Glu Asp Lys Val Asn Val Ala Asp Ile Leu Xaa Lys 
        675                 680                 685             


His Gly Ala Asp Gln Asp Ala His Xaa Lys Leu Gly Tyr Xaa Pro Leu 
    690                 695                 700                 


Ile Val Ala Cys His Tyr Gly Asn Val Lys Met Val Asn Phe Leu Leu 
705                 710                 715                 720 


Lys Gln Gly Ala Asn Val Asn Ala Lys Xaa Lys Asn Gly Tyr Xaa Pro 
                725                 730                 735     


Leu His Gln Ala Ala Gln Gln Gly His Xaa His Ile Ile Asn Val Leu 
            740                 745                 750         


Leu Gln His Gly Ala Lys Pro Asn Ala Xaa Xaa Ala Asn Gly Asn Xaa 
        755                 760                 765             


Ala Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile Ser Val Val Asp Xaa 
    770                 775                 780                 


Leu Lys Val Val Xaa Glu Glu Val Xaa Xaa Xaa Xaa Xaa Xaa Ile Xaa 
785                 790                 795                 800 


Glu Lys His Lys Leu Asn Val Pro Glu Xaa Met Xaa Glu Val Leu Asp 
                805                 810                 815     


Val Ser Asp Glu Glu Gly Asp Asp Xaa Met Xaa Gly Asp Gly Gly Glu 
            820                 825                 830         


Tyr Leu Arg Pro Glu Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro 
        835                 840                 845             


Ser Ser Gln Phe Leu Asp Gly Met Asn Tyr Leu Arg Tyr Ser Leu Glu 
    850                 855                 860                 


Gly Gly Arg Ser Asp Ser Xaa Met Pro Ser Ser Asp Arg Ser His Xaa 
865                 870                 875                 880 


Leu Ser His Ala Ser Tyr Leu Arg Asp Ser Ala Val Met Asp Asp Ser 
                885                 890                 895     


Val Val Ile Pro Ser His Gln Val Ser Xaa Leu Ala Lys Glu Ala Glu 
            900                 905                 910         


Arg Asn Ser Tyr Arg Leu Ser Trp Gly Xaa Glu Asn Leu Asp Asn Val 
        915                 920                 925             


Ala Leu Ser Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met 
    930                 935                 940                 


Val Asp Ala Arg Gly Gly Ala Met Arg Gly Cys Arg His Asn Gly Leu 
945                 950                 955                 960 


Arg Ile Ile Ile Pro Pro Arg Lys Cys Xaa Ala Pro Xaa Arg Val Xaa 
                965                 970                 975     


Cys Arg Leu Val Lys Arg His Arg Leu Ala Xaa Met Pro Pro Met Val 
            980                 985                 990         


Glu Gly Glu Gly Leu Ala Ser Arg  Leu Ile Glu Val Gly  Pro Ser Gly 
        995                 1000                 1005             


Ala Gln  Phe Leu Gly Lys Leu  His Leu Pro Xaa Ala  Pro Pro Pro 
    1010                 1015                 1020             


Leu Asn  Glu Gly Glu Ser Leu  Val Ser Arg Ile Leu  Gln Leu Gly 
    1025                 1030                 1035             


Pro Pro  Gly Xaa Lys Phe Leu  Gly Pro Val Ile Val  Glu Ile Pro 
    1040                 1045                 1050             


His Phe  Ala Ala Leu Arg Gly  Lys Glu Arg Glu Leu  Val Val Leu 
    1055                 1060                 1065             


Arg Ser  Glu Asn Gly Asp Ser  Trp Lys Glu His Phe  Cys Asp Tyr 
    1070                 1075                 1080             


Xaa Glu  Asp Glu Leu Asn Glu  Ile Leu Asn Gly Met  Asp Glu Val 
    1085                 1090                 1095             


Leu Asp  Ser Pro Glu Asp Leu  Glu Lys Lys Arg Ile  Cys Arg Ile 
    1100                 1105                 1110             


Ile Xaa  Arg Asp Phe Pro Gln  Tyr Phe Ala Val Val  Ser Arg Ile 
    1115                 1120                 1125             


Lys Gln  Asp Ser Asn Leu Ile  Gly Pro Glu Gly Gly  Val Leu Ser 
    1130                 1135                 1140             


Ser Xaa  Val Val Pro Gln Val  Gln Ala Val Phe Pro  Glu Gly Ala 
    1145                 1150                 1155             


Leu Xaa  Lys Arg Ile Arg Val  Gly Leu Gln Ala Gln  Pro Met His 
    1160                 1165                 1170             


Ser Glu  Leu Val Lys Lys Ile  Leu Gly Asn Lys Ala  Xaa Phe Ser 
    1175                 1180                 1185             


Pro Ile  Val Xaa Leu Glu Pro  
    1190                 1195 


<210> 2311
<211> 187
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 2311
Xaa Ile Gln Glu Ser Val Xaa Phe Ala Ser Gln Val Tyr Arg Glu Ile 
1               5                   10                  15      


Ile Cys Val Pro Tyr Met Ala Lys Phe Val Val Phe Ala Lys Ser His 
            20                  25                  30          


Asp Pro Ile Glu Ala Arg Leu Arg Cys Phe Cys Met Xaa Asp Asp Lys 
        35                  40                  45              


Val Asp Lys Xaa Leu Glu Gln Gln Glu Asn Phe Ala Glu Val Ala Arg 
    50                  55                  60                  


Ser Arg Asp Val Glu Val Arg Asp Xaa Xaa Gln Glu Pro Cys Gly Arg 
65                  70                  75                  80  


Leu Ser Phe Met Lys Glu Pro Lys Ser Xaa Arg Gly Leu Val His Gln 
                85                  90                  95      


Ala Ile Cys Asn Leu Asn Ile Xaa Leu Pro Ile Tyr Xaa Lys Glu Ser 
            100                 105                 110         


Glu Ser Asp Gln Glu Gln Glu Glu Glu Ile Asp Met Xaa Ser Glu Lys 
        115                 120                 125             


Asn Pro Gln Asp Glu Gln Glu Arg Ile Glu Glu Arg Leu Ala Tyr Ile 
    130                 135                 140                 


Ala Asp His Leu Gly Phe Ser Trp Xaa Glu Leu Ala Arg Glu Leu Asp 
145                 150                 155                 160 


Phe Xaa Glu Glu Gln Ile His Gln Ile Arg Ile Glu Asn Pro Asn Ser 
                165                 170                 175     


Leu Gln Asp Gln Ser His Ala Leu Leu Lys Tyr 
            180                 185         


<210> 2312
<211> 966
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<400> 2312
Xaa Asn Val Ala Leu Ser Ser Ser Pro Ile His Ser Gly Phe Leu Val 
1               5                   10                  15      


Ser Phe Met Val Asp Ala Arg Gly Gly Ala Met Arg Gly Cys Arg His 
            20                  25                  30          


Asn Gly Leu Arg Ile Ile Ile Pro Pro Arg Lys Cys Xaa Ala Pro Xaa 
        35                  40                  45              


Arg Val Xaa Cys Arg Leu Val Lys Arg His Arg Leu Ala Xaa Met Pro 
    50                  55                  60                  


Pro Met Val Glu Gly Glu Gly Leu Ala Ser Arg Leu Ile Glu Val Gly 
65                  70                  75                  80  


Pro Ser Gly Ala Gln Phe Leu Gly Pro Val Ile Val Glu Ile Pro His 
                85                  90                  95      


Phe Ala Ala Leu Arg Gly Lys Glu Arg Glu Leu Val Val Leu Arg Ser 
            100                 105                 110         


Glu Asn Gly Asp Ser Trp Lys Glu His Phe Cys Asp Tyr Xaa Glu Asp 
        115                 120                 125             


Glu Leu Asn Glu Ile Leu Asn Gly Met Asp Glu Val Leu Asp Ser Pro 
    130                 135                 140                 


Glu Asp Leu Glu Lys Lys Arg Ile Cys Arg Ile Ile Xaa Arg Asp Phe 
145                 150                 155                 160 


Pro Gln Tyr Phe Ala Val Val Ser Arg Ile Lys Gln Asp Ser Asn Leu 
                165                 170                 175     


Ile Gly Pro Glu Gly Gly Val Leu Ser Ser Xaa Val Val Pro Gln Val 
            180                 185                 190         


Gln Ala Val Phe Pro Glu Gly Ala Leu Xaa Lys Arg Ile Arg Val Gly 
        195                 200                 205             


Leu Gln Ala Gln Pro Met His Ser Glu Leu Val Lys Lys Ile Leu Gly 
    210                 215                 220                 


Asn Lys Ala Xaa Phe Ser Pro Ile Val Xaa Leu Glu Pro Arg Arg Arg 
225                 230                 235                 240 


Lys Phe His Lys Pro Ile Xaa Met Xaa Ile Pro Val Pro Lys Ala Ser 
                245                 250                 255     


Ser Asp Val Met Leu Asn Gly Phe Gly Gly Asp Ala Pro Xaa Leu Arg 
            260                 265                 270         


Leu Leu Cys Ser Ile Xaa Gly Gly Xaa Xaa Pro Ala Gln Trp Glu Asp 
        275                 280                 285             


Ile Xaa Gly Xaa Xaa Pro Leu Xaa Phe Val Asn Glu Cys Val Ser Phe 
    290                 295                 300                 


Xaa Xaa Asn Val Ser Ala Arg Phe Trp Leu Ile Asp Cys Arg Gln Ile 
305                 310                 315                 320 


Gln Glu Ser Val Xaa Phe Ala Ser Gln Val Tyr Arg Glu Ile Ile Cys 
                325                 330                 335     


Val Pro Tyr Met Ala Lys Phe Val Val Phe Ala Lys Ser His Asp Pro 
            340                 345                 350         


Ile Glu Ala Arg Leu Arg Cys Phe Cys Met Xaa Asp Asp Lys Val Asp 
        355                 360                 365             


Lys Xaa Leu Glu Gln Gln Glu Asn Phe Ala Glu Val Ala Arg Ser Arg 
    370                 375                 380                 


Asp Val Glu Val Leu Glu Gly Lys Pro Ile Tyr Val Asp Cys Phe Gly 
385                 390                 395                 400 


Asn Leu Val Pro Leu Xaa Lys Ser Gly Gln His His Ile Phe Ser Phe 
                405                 410                 415     


Phe Ala Phe Lys Glu Asn Arg Leu Pro Leu Phe Val Lys Val Arg Asp 
            420                 425                 430         


Xaa Xaa Gln Glu Pro Cys Gly Arg Leu Ser Phe Met Lys Glu Pro Lys 
        435                 440                 445             


Ser Xaa Arg Gly Leu Val His Gln Ala Ile Cys Asn Leu Asn Ile Xaa 
    450                 455                 460                 


Leu Pro Ile Tyr Xaa Lys Ile Asp Met Xaa Ser Glu Lys Asn Pro Gln 
465                 470                 475                 480 


Asp Glu Gln Glu Arg Ile Glu Glu Arg Leu Ala Tyr Ile Ala Asp His 
                485                 490                 495     


Leu Gly Phe Ser Trp Xaa Glu Leu Ala Arg Glu Leu Asp Phe Xaa Glu 
            500                 505                 510         


Glu Gln Ile His Gln Ile Arg Ile Glu Asn Pro Asn Ser Leu Gln Asp 
        515                 520                 525             


Gln Ser His Ala Leu Leu Lys Tyr Trp Leu Glu Arg Asp Gly Lys His 
    530                 535                 540                 


Ala Xaa Asp Xaa Asn Leu Val Glu Cys Leu Xaa Lys Ile Asn Arg Met 
545                 550                 555                 560 


Asp Ile Val His Leu Met Glu Xaa Asn Xaa Glu Pro Leu Gln Glu Arg 
                565                 570                 575     


Ile Ser His Ser Tyr Ala Glu Ile Glu Gln Xaa Ile Xaa Leu Asp His 
            580                 585                 590         


Ser Glu Gly Phe Ser Val Leu Gln Glu Glu Leu Cys Xaa Ala Gln His 
        595                 600                 605             


Lys Gln Lys Glu Glu Gln Ala Val Ser Lys Glu Ser Glu Xaa Cys Asp 
    610                 615                 620                 


His Pro Pro Ile Val Ser Glu Glu Asp Ile Ser Val Gly Tyr Ser Xaa 
625                 630                 635                 640 


Phe Gln Asp Gly Val Pro Lys Xaa Glu Gly Asp Ser Ser Ala Xaa Ala 
                645                 650                 655     


Leu Phe Pro Gln Xaa His Lys Glu Gln Val Gln Gln Asp Phe Ser Gly 
            660                 665                 670         


Lys Met Gln Asp Leu Pro Glu Glu Ser Ser Leu Glu Tyr Gln Gln Glu 
        675                 680                 685             


Tyr Phe Val Xaa Xaa Pro Gly Xaa Glu Xaa Ser Glu Xaa Gln Lys Ala 
    690                 695                 700                 


Met Ile Val Pro Ser Ser Pro Ser Lys Xaa Pro Glu Glu Val Ser Xaa 
705                 710                 715                 720 


Pro Ala Glu Glu Glu Lys Leu Tyr Leu Gln Xaa Pro Xaa Ser Ser Glu 
                725                 730                 735     


Arg Gly Gly Ser Pro Ile Ile Gln Glu Pro Glu Glu Pro Ser Glu His 
            740                 745                 750         


Arg Glu Glu Ser Ser Pro Arg Lys Xaa Ser Leu Val Ile Val Glu Ser 
        755                 760                 765             


Ala Asp Asn Gln Pro Glu Xaa Cys Glu Arg Leu Asp Glu Asp Ala Ala 
    770                 775                 780                 


Phe Glu Lys Glu Leu Xaa Glu Glu Leu Gly Glu Leu Glu Ala Ser Ser 
785                 790                 795                 800 


Asp Glu Glu Ala Met Val Xaa Xaa Arg Val Val Arg Arg Arg Val Ile 
                805                 810                 815     


Ile Gln Gly Asp Asp Met Pro Glu Ile Pro Pro Glu Xaa Val Xaa Glu 
            820                 825                 830         


Glu Glu Tyr Ile Asp Glu His Gly His Xaa Val Val Lys Lys Val Xaa 
        835                 840                 845             


Arg Lys Ile Ile Arg Arg Tyr Val Ser Ser Glu Gly Xaa Glu Lys Glu 
    850                 855                 860                 


Glu Ile Met Val Gln Gly Met Pro Gln Glu Pro Val Asn Ile Glu Glu 
865                 870                 875                 880 


Gly Asp Gly Tyr Ser Lys Val Ile Lys Arg Val Val Leu Lys Ser Asp 
                885                 890                 895     


Xaa Glu Gln Ser Glu Val Xaa Leu Cys Glu Pro Ser Ile Leu Ser Ser 
            900                 905                 910         


Xaa Ser Gln Phe Gln Ala Glu Pro Val Glu Gly Arg Arg Val Ser Lys 
        915                 920                 925             


Val Val Lys Xaa Xaa Val Val Leu Gly Glu Arg Met Glu Lys His Leu 
    930                 935                 940                 


Gly Asp Ser Ser Leu Ala Xaa Asp Leu Pro Ser Ala Lys Asp Asp Phe 
945                 950                 955                 960 


Glu Glu Asp Asn Asn Glu 
                965     


<210> 2313
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<400> 2313
Xaa Pro Gln Glu Pro Val Asn Ile Glu Glu Gly Asp Gly Tyr Ser Lys 
1               5                   10                  15      


Val Ile Lys Arg Val Val Leu Lys Ser Asp Xaa Glu Gln Ser Glu Ala 
            20                  25                  30          


Leu Ser Tyr Xaa Gly Ser His Met Lys Val His Leu Pro Ser Leu Val 
        35                  40                  45              


Glu Asn Glu Ile Leu Lys Glu Asp Gly Ser Ile Ile Lys Arg Xaa Xaa 
    50                  55                  60                  


Met Ser Lys Ala Ile Xaa Gln Lys Arg Ala Val Val Lys Asp Gln His 
65                  70                  75                  80  


Gly 
    


<210> 2314
<211> 197
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<400> 2314
Xaa Ser Glu Gly Xaa Glu Lys Glu Glu Ile Met Val Gln Gly Met Pro 
1               5                   10                  15      


Gln Glu Pro Val Asn Ile Glu Glu Gly Asp Gly Tyr Ser Lys Val Ile 
            20                  25                  30          


Lys Arg Val Val Leu Lys Ser Asp Xaa Glu Gln Ser Glu Val Xaa Leu 
        35                  40                  45              


Cys Glu Pro Ser Ile Leu Ser Ser Xaa Ser Gln Phe Gln Ala Glu Pro 
    50                  55                  60                  


Val Glu Gly Arg Arg Val Ser Lys Val Val Lys Xaa Xaa Val Val Leu 
65                  70                  75                  80  


Gly Glu Arg Met Glu Lys His Leu Gly Asp Ser Ser Leu Ala Xaa Asp 
                85                  90                  95      


Leu Pro Ser Ala Lys Asp Asp Phe Glu Glu Ala Leu Ser Tyr Xaa Gly 
            100                 105                 110         


Ser His Met Lys Val His Leu Pro Ser Leu Val Glu Asn Glu Ile Leu 
        115                 120                 125             


Lys Glu Asp Gly Ser Ile Ile Lys Arg Xaa Xaa Met Ser Lys Ala Ile 
    130                 135                 140                 


Xaa Gln Lys Arg Ala Val Val Lys Asp Gln His Gly Lys Arg Ile Asp 
145                 150                 155                 160 


Leu Glu His Leu Glu Asp Val Pro Glu Ala Leu Asp Gln Asp Asp Leu 
                165                 170                 175     


Gln Arg Asp Leu Gln Gln Leu Leu Arg His Phe Cys Lys Glu Asp Leu 
            180                 185                 190         


Lys Gln Glu Ala Lys 
        195         


<210> 2315
<211> 4377
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1238)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1252)..(1252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1267)..(1267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1276)..(1277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1294)..(1294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1299)..(1299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1377)..(1377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1435)..(1435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1443)..(1443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1454)..(1454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1482)..(1482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1485)..(1485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1490)..(1491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1500)..(1500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1507)..(1508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1512)..(1512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1522)..(1522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1531)..(1531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1552)..(1552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1557)..(1558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1576)..(1576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1583)..(1583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1598)..(1598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1619)..(1619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1624)..(1624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1628)..(1629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1642)..(1642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1665)..(1665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1695)..(1695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1730)..(1730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1738)..(1738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1749)..(1749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1762)..(1762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1769)..(1771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1794)..(1794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1802)..(1802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1811)..(1812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1816)..(1816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1821)..(1821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1846)..(1846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1858)..(1858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1860)..(1861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1863)..(1863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1872)..(1872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1891)..(1891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1916)..(1916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1921)..(1921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2031)..(2031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2038)..(2038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2047)..(2047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2088)..(2088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2090)..(2090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2105)..(2105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2107)..(2107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2132)..(2132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2137)..(2137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2147)..(2147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2163)..(2163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2165)..(2165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2167)..(2167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2186)..(2186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2199)..(2199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2208)..(2209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2244)..(2244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2247)..(2250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2270)..(2270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2311)..(2311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2343)..(2343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2350)..(2350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2398)..(2398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2414)..(2414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2437)..(2437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2480)..(2480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2485)..(2485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2508)..(2508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2540)..(2540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2560)..(2560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2580)..(2580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2589)..(2589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2599)..(2599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2627)..(2627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2637)..(2637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2682)..(2682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2688)..(2688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2726)..(2726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2789)..(2789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2814)..(2814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2838)..(2838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2843)..(2843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2854)..(2854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2861)..(2861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2901)..(2901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2909)..(2909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2920)..(2920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3003)..(3003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3006)..(3006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3018)..(3018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3041)..(3041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3043)..(3043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3046)..(3046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3083)..(3083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3091)..(3091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3124)..(3124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3128)..(3128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3131)..(3131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3134)..(3135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3152)..(3152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3168)..(3168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3171)..(3171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3182)..(3182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3185)..(3185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3216)..(3216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3221)..(3222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3226)..(3226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3333)..(3333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3393)..(3393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3399)..(3400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3407)..(3407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3410)..(3410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3428)..(3428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3448)..(3448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3490)..(3490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3494)..(3494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3504)..(3504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3518)..(3518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3530)..(3530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3534)..(3534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3537)..(3537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3564)..(3564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3578)..(3579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3582)..(3583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3587)..(3587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3589)..(3589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3593)..(3593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3595)..(3595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3612)..(3612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3638)..(3638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3655)..(3655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3657)..(3657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3665)..(3666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3669)..(3669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3677)..(3677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3679)..(3679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3688)..(3688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3696)..(3696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3709)..(3709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3711)..(3711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3720)..(3720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3730)..(3730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3732)..(3732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3742)..(3742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3750)..(3750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3759)..(3759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3761)..(3761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3766)..(3766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3796)..(3796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3799)..(3799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3809)..(3809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3815)..(3815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3817)..(3818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3832)..(3832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3853)..(3853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3870)..(3870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3875)..(3875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3884)..(3884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3898)..(3898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3902)..(3903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3918)..(3918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3932)..(3932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3957)..(3957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3960)..(3965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3967)..(3978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3981)..(3981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4007)..(4007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4032)..(4032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4036)..(4036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4041)..(4041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4050)..(4051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4059)..(4059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4081)..(4081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4090)..(4090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4106)..(4106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4143)..(4143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4150)..(4151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4155)..(4155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4159)..(4159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4168)..(4168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4183)..(4183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4204)..(4204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4219)..(4219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4238)..(4238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4255)..(4255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4258)..(4258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4263)..(4263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4279)..(4279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4282)..(4282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4310)..(4310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4318)..(4318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4332)..(4332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4364)..(4364)
<223> Selenocysteine

<400> 2315
Met Ala His Ala Ala Ser Gln Leu Lys Lys Asn Arg Asp Leu Glu Ile 
1               5                   10                  15      


Asn Ala Glu Glu Glu Pro Glu Lys Lys Arg Lys His Arg Lys Arg Ser 
            20                  25                  30          


Arg Asp Arg Lys Lys Lys Ser Asp Ala Asn Ala Ser Tyr Leu Arg Ala 
        35                  40                  45              


Ala Arg Ala Gly His Leu Glu Lys Ala Leu Asp Tyr Ile Lys Asn Gly 
    50                  55                  60                  


Val Asp Ile Asn Ile Cys Asn Gln Asn Gly Leu Asn Ala Leu His Leu 
65                  70                  75                  80  


Ala Ser Lys Glu Gly His Val Glu Val Val Ser Glu Leu Leu Gln Arg 
                85                  90                  95      


Glu Ala Asn Val Asp Ala Ala Xaa Lys Lys Gly Asn Xaa Ala Leu His 
            100                 105                 110         


Ile Ala Ser Leu Ala Gly Gln Ala Glu Val Val Lys Val Leu Val Xaa 
        115                 120                 125             


Asn Gly Ala Asn Val Asn Ala Gln Ser Gln Asn Gly Phe Xaa Pro Leu 
    130                 135                 140                 


Tyr Met Ala Ala Gln Glu Asn His Leu Glu Val Val Lys Phe Leu Leu 
145                 150                 155                 160 


Asp Asn Gly Ala Ser Gln Ser Leu Ala Xaa Glu Asp Gly Phe Xaa Pro 
                165                 170                 175     


Leu Ala Val Ala Leu Gln Gln Gly His Asp Gln Val Val Ser Leu Leu 
            180                 185                 190         


Leu Glu Asn Asp Xaa Lys Gly Lys Val Arg Leu Pro Ala Leu His Ile 
        195                 200                 205             


Ala Ala Arg Lys Asp Asp Xaa Lys Ala Ala Ala Leu Leu Leu Gln Asn 
    210                 215                 220                 


Asp Asn Asn Ala Asp Val Glu Ser Lys Ser Gly Phe Xaa Pro Leu His 
225                 230                 235                 240 


Ile Ala Ala His Tyr Gly Asn Ile Asn Val Ala Xaa Leu Leu Leu Asn 
                245                 250                 255     


Arg Ala Ala Ala Val Asp Phe Xaa Ala Arg Asn Asp Ile Xaa Pro Leu 
            260                 265                 270         


His Val Ala Ser Lys Arg Gly Asn Ala Asn Met Val Lys Leu Leu Leu 
        275                 280                 285             


Asp Arg Gly Ala Lys Ile Asp Ala Lys Xaa Arg Asp Gly Leu Xaa Pro 
    290                 295                 300                 


Leu His Cys Gly Ala Arg Ser Gly His Glu Gln Val Val Glu Met Leu 
305                 310                 315                 320 


Leu Asp Arg Ala Ala Pro Ile Leu Ser Lys Xaa Lys Asn Gly Leu Ser 
                325                 330                 335     


Pro Leu His Met Ala Xaa Gln Gly Asp His Leu Asn Cys Val Gln Leu 
            340                 345                 350         


Leu Leu Gln His Asn Val Pro Val Asp Asp Val Xaa Asn Asp Tyr Leu 
        355                 360                 365             


Xaa Ala Leu His Val Ala Ala His Cys Gly His Tyr Lys Val Ala Lys 
    370                 375                 380                 


Val Leu Leu Asp Lys Lys Ala Asn Pro Asn Ala Lys Ala Leu Asn Gly 
385                 390                 395                 400 


Phe Xaa Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met 
                405                 410                 415     


Glu Leu Leu Leu Lys His Gly Ala Ser Ile Gln Ala Val Xaa Glu Ser 
            420                 425                 430         


Gly Leu Xaa Pro Ile His Val Ala Ala Phe Met Gly His Val Asn Ile 
        435                 440                 445             


Val Ser Gln Leu Met His His Gly Ala Ser Pro Asn Xaa Xaa Asn Val 
    450                 455                 460                 


Arg Gly Glu Xaa Ala Leu His Met Ala Ala Arg Ser Gly Gln Ala Glu 
465                 470                 475                 480 


Val Val Arg Tyr Leu Val Gln Asp Gly Ala Gln Val Glu Ala Lys Ala 
                485                 490                 495     


Lys Asp Asp Gln Xaa Pro Leu His Ile Ser Ala Arg Leu Gly Lys Ala 
            500                 505                 510         


Asp Ile Val Gln Gln Leu Leu Gln Gln Gly Ala Ser Pro Asn Ala Ala 
        515                 520                 525             


Xaa Xaa Ser Gly Tyr Xaa Pro Leu His Leu Ser Ala Arg Glu Gly His 
    530                 535                 540                 


Glu Asp Val Ala Ala Phe Leu Leu Asp His Gly Ala Ser Leu Ser Ile 
545                 550                 555                 560 


Xaa Xaa Lys Lys Gly Phe Xaa Pro Leu His Val Ala Ala Lys Tyr Gly 
                565                 570                 575     


Lys Leu Glu Val Ala Asn Leu Leu Leu Gln Lys Ser Ala Ser Pro Asp 
            580                 585                 590         


Ala Ala Gly Lys Ser Gly Leu Xaa Pro Leu His Val Ala Ala His Tyr 
        595                 600                 605             


Asp Asn Gln Lys Val Ala Leu Leu Leu Leu Asp Gln Gly Ala Ser Pro 
    610                 615                 620                 


His Ala Ala Ala Lys Asn Gly Tyr Xaa Pro Leu His Ile Ala Ala Lys 
625                 630                 635                 640 


Lys Asn Gln Met Asp Ile Ala Xaa Xaa Leu Leu Glu Tyr Gly Ala Asp 
                645                 650                 655     


Ala Asn Ala Val Xaa Arg Gln Gly Ile Ala Ser Val His Leu Ala Ala 
            660                 665                 670         


Gln Glu Gly His Val Asp Met Val Ser Leu Leu Leu Gly Arg Asn Ala 
        675                 680                 685             


Asn Val Asn Leu Ser Asn Lys Ser Gly Leu Xaa Pro Leu His Leu Ala 
    690                 695                 700                 


Ala Gln Glu Asp Arg Val Asn Val Ala Glu Val Leu Val Asn Gln Gly 
705                 710                 715                 720 


Ala His Val Asp Ala Gln Xaa Lys Met Gly Tyr Xaa Pro Leu His Val 
                725                 730                 735     


Gly Cys His Tyr Gly Asn Ile Lys Ile Val Asn Phe Leu Leu Gln His 
            740                 745                 750         


Ser Ala Lys Val Asn Ala Lys Xaa Lys Asn Gly Tyr Xaa Pro Leu His 
        755                 760                 765             


Gln Ala Ala Gln Gln Gly His Xaa His Ile Ile Asn Val Leu Leu Gln 
    770                 775                 780                 


Asn Asn Ala Ser Pro Asn Glu Leu Xaa Val Asn Gly Asn Xaa Ala Leu 
785                 790                 795                 800 


Gly Ile Ala Arg Arg Leu Gly Tyr Ile Ser Val Val Asp Xaa Leu Lys 
                805                 810                 815     


Ile Val Xaa Glu Glu Xaa Met Xaa Xaa Xaa Xaa Val Xaa Glu Lys His 
            820                 825                 830         


Lys Met Asn Val Pro Glu Xaa Met Asn Glu Val Leu Asp Met Ser Asp 
        835                 840                 845             


Asp Glu Val Arg Lys Ala Asn Ala Pro Glu Met Leu Ser Asp Gly Glu 
    850                 855                 860                 


Tyr Ile Ser Asp Val Glu Glu Gly Glu Asp Ala Met Xaa Gly Asp Xaa 
865                 870                 875                 880 


Asp Lys Tyr Leu Gly Pro Gln Asp Leu Lys Glu Leu Gly Asp Asp Ser 
                885                 890                 895     


Leu Pro Ala Glu Gly Tyr Met Gly Phe Ser Leu Gly Ala Arg Ser Ala 
            900                 905                 910         


Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser Tyr Xaa Leu Asn Arg Ser 
        915                 920                 925             


Ser Tyr Ala Arg Asp Ser Met Met Ile Glu Glu Leu Leu Val Pro Ser 
    930                 935                 940                 


Lys Glu Gln His Leu Xaa Phe Xaa Arg Glu Phe Asp Ser Asp Ser Leu 
945                 950                 955                 960 


Arg His Tyr Ser Trp Ala Ala Asp Xaa Leu Asp Asn Val Asn Leu Val 
                965                 970                 975     


Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala 
            980                 985                 990         


Arg Gly Gly Ser Met Arg Gly Ser  Arg His His Gly Met  Arg Ile Ile 
        995                 1000                 1005             


Ile Pro  Pro Arg Lys Cys Xaa  Ala Pro Xaa Arg Ile  Xaa Cys Arg 
    1010                 1015                 1020             


Leu Val  Lys Arg His Lys Leu  Ala Asn Pro Pro Pro  Met Val Glu 
    1025                 1030                 1035             


Gly Glu  Gly Leu Ala Ser Arg  Leu Val Glu Met Gly  Pro Ala Gly 
    1040                 1045                 1050             


Ala Gln  Phe Leu Gly Pro Val  Ile Val Glu Ile Pro  His Phe Gly 
    1055                 1060                 1065             


Ser Met  Arg Gly Lys Glu Arg  Glu Leu Ile Val Leu  Arg Ser Glu 
    1070                 1075                 1080             


Asn Gly  Glu Xaa Trp Lys Glu  His Gln Phe Asp Ser  Lys Asn Glu 
    1085                 1090                 1095             


Asp Leu  Xaa Glu Leu Leu Asn  Gly Met Asp Glu Glu  Leu Asp Ser 
    1100                 1105                 1110             


Pro Glu  Glu Leu Gly Lys Lys  Arg Ile Cys Arg Ile  Ile Xaa Lys 
    1115                 1120                 1125             


Asp Phe  Pro Gln Tyr Phe Ala  Val Val Ser Arg Ile  Lys Gln Glu 
    1130                 1135                 1140             


Ser Asn  Gln Ile Gly Pro Glu  Gly Gly Ile Leu Ser  Ser Xaa Xaa 
    1145                 1150                 1155             


Val Pro  Leu Val Gln Ala Ser  Phe Pro Glu Gly Ala  Leu Xaa Lys 
    1160                 1165                 1170             


Arg Ile  Arg Val Gly Leu Gln  Ala Gln Pro Val Pro  Asp Glu Ile 
    1175                 1180                 1185             


Val Lys  Lys Ile Leu Gly Asn  Lys Ala Xaa Phe Ser  Pro Ile Val 
    1190                 1195                 1200             


Xaa Val  Glu Pro Arg Arg Arg  Lys Phe His Lys Pro  Ile Xaa Met 
    1205                 1210                 1215             


Xaa Ile  Pro Val Pro Pro Pro  Ser Gly Glu Gly Val  Ser Asn Gly 
    1220                 1225                 1230             


Tyr Lys  Gly Asp Xaa Xaa Pro  Asn Leu Arg Leu Leu  Cys Ser Ile 
    1235                 1240                 1245             


Xaa Gly  Gly Xaa Ser Pro Ala  Gln Trp Glu Asp Ile  Xaa Gly Xaa 
    1250                 1255                 1260             


Xaa Pro  Leu Xaa Phe Ile Lys  Asp Cys Val Ser Phe  Xaa Xaa Asn 
    1265                 1270                 1275             


Val Ser  Ala Arg Phe Trp Leu  Ala Asp Cys His Gln  Val Leu Glu 
    1280                 1285                 1290             


Xaa Val  Gly Leu Ala Xaa Gln  Leu Tyr Arg Glu Leu  Ile Cys Val 
    1295                 1300                 1305             


Pro Tyr  Met Ala Lys Phe Val  Val Phe Ala Lys Met  Asn Asp Pro 
    1310                 1315                 1320             


Val Glu  Ser Ser Leu Arg Cys  Phe Cys Met Xaa Asp  Asp Lys Val 
    1325                 1330                 1335             


Asp Lys  Xaa Leu Glu Gln Gln  Glu Asn Phe Glu Glu  Val Ala Arg 
    1340                 1345                 1350             


Ser Lys  Asp Ile Glu Val Leu  Glu Gly Lys Pro Ile  Tyr Val Asp 
    1355                 1360                 1365             


Cys Tyr  Gly Asn Leu Ala Pro  Leu Xaa Lys Gly Gly  Gln Gln Leu 
    1370                 1375                 1380             


Val Phe  Asn Phe Tyr Ser Phe  Lys Glu Asn Arg Leu  Pro Phe Ser 
    1385                 1390                 1395             


Ile Lys  Ile Arg Asp Xaa Ser  Gln Glu Pro Cys Gly  Arg Leu Ser 
    1400                 1405                 1410             


Phe Leu  Lys Glu Pro Lys Xaa  Xaa Lys Gly Leu Pro  Gln Xaa Ala 
    1415                 1420                 1425             


Val Cys  Asn Leu Asn Ile Xaa  Leu Pro Ala His Lys  Lys Glu Xaa 
    1430                 1435                 1440             


Glu Ser  Asp Gln Asp Asp Glu  Ile Glu Lys Xaa Asp  Arg Arg Gln 
    1445                 1450                 1455             


Ser Phe  Ala Ser Leu Ala Leu  Arg Lys Arg Tyr Ser  Tyr Leu Xaa 
    1460                 1465                 1470             


Glu Pro  Gly Met Ile Glu Arg  Ser Xaa Gly Ala Xaa  Arg Ser Leu 
    1475                 1480                 1485             


Pro Xaa  Xaa Tyr Ser Tyr Lys  Pro Phe Phe Ser Xaa  Arg Pro Tyr 
    1490                 1495                 1500             


Gln Ser  Trp Xaa Xaa Ala Pro  Ile Xaa Val Pro Gly  Pro Ala Lys 
    1505                 1510                 1515             


Ser Gly  Phe Xaa Ser Leu Ser  Ser Ser Ser Ser Asn  Xaa Pro Ser 
    1520                 1525                 1530             


Ala Ser  Pro Leu Lys Ser Ile  Trp Ser Val Ser Xaa  Pro Ser Pro 
    1535                 1540                 1545             


Ile Lys  Ser Xaa Leu Gly Ala  Ser Xaa Xaa Ser Ser  Val Lys Ser 
    1550                 1555                 1560             


Ile Ser  Asp Val Ala Ser Pro  Ile Arg Ser Phe Arg  Xaa Met Ser 
    1565                 1570                 1575             


Ser Pro  Ile Lys Xaa Val Val  Ser Gln Ser Pro Tyr  Asn Ile Gln 
    1580                 1585                 1590             


Val Ser  Ser Gly Xaa Leu Ala  Arg Ala Pro Ala Val  Xaa Glu Ala 
    1595                 1600                 1605             


Xaa Pro  Leu Lys Gly Leu Ala  Ser Asn Ser Xaa Phe  Ser Ser Arg 
    1610                 1615                 1620             


Xaa Ser  Pro Val Xaa Xaa Ala  Gly Ser Leu Leu Glu  Arg Ser Ser 
    1625                 1630                 1635             


Ile Xaa  Met Xaa Pro Pro Ala  Ser Pro Lys Ser Asn  Ile Asn Met 
    1640                 1645                 1650             


Tyr Ser  Ser Ser Leu Pro Phe  Lys Ser Ile Ile Xaa  Ser Ala Ala 
    1655                 1660                 1665             


Pro Leu  Ile Ser Ser Pro Leu  Lys Ser Val Val Ser  Pro Val Lys 
    1670                 1675                 1680             


Ser Ala  Val Asp Val Ile Ser  Ser Ala Lys Ile Xaa  Met Ala Ser 
    1685                 1690                 1695             


Ser Leu  Ser Ser Pro Val Lys  Gln Met Pro Gly His  Ala Glu Val 
    1700                 1705                 1710             


Ala Leu  Val Asn Gly Ser Ile  Ser Pro Leu Lys Tyr  Pro Ser Ser 
    1715                 1720                 1725             


Ser Xaa  Leu Ile Asn Gly Cys  Lys Ala Xaa Ala Xaa  Leu Gln Glu 
    1730                 1735                 1740             


Lys Ile  Ser Ser Ala Xaa Asn  Ser Val Ser Ser Val  Val Ser Ala 
    1745                 1750                 1755             


Ala Xaa  Asp Xaa Val Glu Lys  Val Phe Ser Xaa Xaa  Xaa Ala Met 
    1760                 1765                 1770             


Pro Phe  Ser Pro Leu Arg Ser  Tyr Val Ser Ala Ala  Pro Ser Ala 
    1775                 1780                 1785             


Phe Gln  Ser Leu Arg Xaa Pro  Ser Ala Ser Ala Leu  Tyr Xaa Ser 
    1790                 1795                 1800             


Leu Gly  Ser Ser Ile Ser Ala  Xaa Xaa Ser Ser Val  Xaa Ser Ser 
    1805                 1810                 1815             


Ile Ile  Xaa Val Pro Val Tyr  Ser Val Val Asn Val  Leu Pro Glu 
    1820                 1825                 1830             


Pro Ala  Leu Lys Lys Leu Pro  Asp Ser Asn Ser Phe  Xaa Lys Ser 
    1835                 1840                 1845             


Ala Ala  Ala Leu Leu Ser Pro  Ile Lys Xaa Leu Xaa  Xaa Glu Xaa 
    1850                 1855                 1860             


His Pro  Gln Pro His Phe Ser  Arg Xaa Ser Ser Pro  Val Lys Ser 
    1865                 1870                 1875             


Ser Leu  Phe Leu Ala Pro Ser  Ala Leu Lys Leu Ser  Xaa Pro Ser 
    1880                 1885                 1890             


Ser Leu  Ser Ser Ser Gln Glu  Ile Leu Lys Asp Val  Ala Glu Met 
    1895                 1900                 1905             


Lys Glu  Asp Leu Met Arg Met  Xaa Ala Ile Leu Gln  Xaa Asp Val 
    1910                 1915                 1920             


Pro Glu  Glu Lys Pro Phe Gln  Pro Glu Leu Pro Lys  Glu Gly Arg 
    1925                 1930                 1935             


Ile Asp  Asp Glu Glu Pro Phe  Lys Ile Val Glu Lys  Val Lys Glu 
    1940                 1945                 1950             


Asp Leu  Val Lys Val Ser Glu  Ile Leu Lys Lys Asp  Val Cys Val 
    1955                 1960                 1965             


Asp Asn  Lys Gly Ser Pro Lys  Ser Pro Lys Ser Asp  Lys Gly His 
    1970                 1975                 1980             


Ser Pro  Glu Asp Asp Trp Ile  Glu Phe Ser Ser Glu  Glu Ile Arg 
    1985                 1990                 1995             


Glu Ala  Arg Gln Gln Ala Ala  Ala Ser Gln Ser Pro  Ser Leu Pro 
    2000                 2005                 2010             


Glu Arg  Val Gln Val Lys Ala  Lys Ala Ala Ser Glu  Lys Asp Tyr 
    2015                 2020                 2025             


Asn Leu  Xaa Lys Val Ile Asp  Tyr Leu Xaa Asn Asp  Ile Gly Ser 
    2030                 2035                 2040             


Ser Ser  Leu Xaa Asn Leu Lys  Tyr Lys Phe Glu Asp  Ala Lys Lys 
    2045                 2050                 2055             


Asp Gly  Glu Glu Arg Gln Lys  Arg Val Leu Lys Pro  Ala Ile Ala 
    2060                 2065                 2070             


Leu Gln  Glu His Lys Leu Lys  Met Pro Pro Ala Ser  Met Arg Xaa 
    2075                 2080                 2085             


Ser Xaa  Ser Glu Lys Glu Leu  Cys Lys Met Ala Asp  Ser Phe Phe 
    2090                 2095                 2100             


Gly Xaa  Asp Xaa Ile Leu Glu  Ser Pro Asp Asp Phe  Ser Gln His 
    2105                 2110                 2115             


Asp Gln  Asp Lys Ser Pro Leu  Ser Asp Ser Gly Phe  Glu Xaa Arg 
    2120                 2125                 2130             


Ser Glu  Lys Xaa Pro Ser Ala  Pro Gln Ser Ala Glu  Ser Xaa Gly 
    2135                 2140                 2145             


Pro Lys  Pro Leu Phe His Glu  Val Pro Ile Pro Pro  Val Ile Xaa 
    2150                 2155                 2160             


Glu Xaa  Arg Xaa Glu Val Val  His Val Ile Arg Ser  Tyr Asp Pro 
    2165                 2170                 2175             


Ser Ala  Gly Asp Val Pro Gln  Xaa Gln Pro Glu Glu  Pro Val Ser 
    2180                 2185                 2190             


Pro Lys  Pro Ser Pro Xaa Phe  Met Glu Leu Glu Pro  Lys Pro Xaa 
    2195                 2200                 2205             


Xaa Ser  Ser Ile Lys Glu Lys  Val Lys Ala Phe Gln  Met Lys Ala 
    2210                 2215                 2220             


Ser Ser  Glu Glu Asp Asp His  Asn Arg Val Leu Ser  Lys Gly Met 
    2225                 2230                 2235             


Arg Val  Lys Glu Glu Xaa His  Ile Xaa Xaa Xaa Xaa  Arg Met Val 
    2240                 2245                 2250             


Tyr His  Ser Pro Pro Gly Gly  Glu Gly Ala Ser Glu  Arg Ile Glu 
    2255                 2260                 2265             


Glu Xaa  Met Ser Val His Asp  Ile Met Lys Ala Phe  Gln Ser Gly 
    2270                 2275                 2280             


Arg Asp  Pro Ser Lys Glu Leu  Ala Gly Leu Phe Glu  His Lys Ser 
    2285                 2290                 2295             


Ala Val  Ser Pro Asp Val His  Lys Ser Ala Ala Glu  Xaa Ser Ala 
    2300                 2305                 2310             


Gln His  Ala Glu Lys Asp Asn  Gln Met Lys Pro Lys  Leu Glu Arg 
    2315                 2320                 2325             


Ile Ile  Glu Val His Ile Glu  Lys Gly Asn Gln Ala  Glu Pro Xaa 
    2330                 2335                 2340             


Glu Val  Ile Ile Arg Glu Xaa  Lys Lys His Pro Glu  Lys Glu Met 
    2345                 2350                 2355             


Tyr Val  Tyr Gln Lys Asp Leu  Ser Arg Gly Asp Ile  Asn Leu Lys 
    2360                 2365                 2370             


Asp Phe  Leu Pro Glu Lys His  Asp Ala Phe Pro Cys  Ser Glu Glu 
    2375                 2380                 2385             


Gln Gly  Gln Gln Glu Glu Glu  Glu Leu Xaa Ala Glu  Glu Ser Leu 
    2390                 2395                 2400             


Pro Ser  Tyr Leu Glu Ser Ser  Arg Val Asn Xaa Pro  Val Ser Gln 
    2405                 2410                 2415             


Glu Glu  Asp Ser Arg Pro Ser  Ser Ala Gln Leu Ile  Ser Asp Asp 
    2420                 2425                 2430             


Ser Tyr  Lys Xaa Leu Lys Leu  Leu Ser Gln His Ser  Ile Glu Tyr 
    2435                 2440                 2445             


His Asp  Asp Glu Leu Ser Glu  Leu Arg Gly Glu Ser  Tyr Arg Phe 
    2450                 2455                 2460             


Ala Glu  Lys Met Leu Leu Ser  Glu Lys Leu Asp Val  Ser His Ser 
    2465                 2470                 2475             


Asp Xaa  Glu Glu Ser Val Xaa  Asp His Ala Gly Pro  Pro Ser Ser 
    2480                 2485                 2490             


Glu Leu  Gln Gly Ser Asp Lys  Arg Ser Arg Glu Lys  Ile Ala Xaa 
    2495                 2500                 2505             


Ala Pro  Lys Lys Glu Ile Leu  Ser Lys Ile Tyr Lys  Asp Val Ser 
    2510                 2515                 2520             


Glu Asn  Gly Val Gly Lys Val  Ser Lys Asp Glu His  Phe Asp Lys 
    2525                 2530                 2535             


Val Xaa  Val Leu His Tyr Ser  Gly Asn Val Ser Ser  Pro Lys His 
    2540                 2545                 2550             


Ala Met  Trp Met Arg Phe Xaa  Glu Asp Arg Leu Asp  Arg Gly Arg 
    2555                 2560                 2565             


Glu Lys  Leu Ile Tyr Glu Asp  Arg Val Asp Arg Xaa  Val Lys Glu 
    2570                 2575                 2580             


Ala Glu  Glu Lys Leu Xaa Glu  Val Ser Gln Phe Phe  Arg Asp Lys 
    2585                 2590                 2595             


Xaa Glu  Lys Leu Asn Asp Glu  Leu Gln Ser Pro Glu  Lys Lys Ala 
    2600                 2605                 2610             


Arg Pro  Lys Asn Gly Lys Glu  Tyr Ser Ser Gln Ser  Pro Xaa Ser 
    2615                 2620                 2625             


Ser Ser  Pro Glu Lys Val Leu  Leu Xaa Glu Leu Leu  Ala Ser Asn 
    2630                 2635                 2640             


Asp Glu  Trp Val Lys Ala Arg  Gln His Gly Pro Asp  Gly Gln Gly 
    2645                 2650                 2655             


Phe Pro  Lys Ala Glu Glu Lys  Ala Pro Ser Leu Pro  Ser Ser Pro 
    2660                 2665                 2670             


Glu Lys  Met Val Leu Ser Gln  Gln Xaa Glu Asp Ser  Lys Ser Xaa 
    2675                 2680                 2685             


Val Glu  Ala Lys Gly Ser Ile  Ser Gln Ser Lys Ala  Pro Asp Gly 
    2690                 2695                 2700             


Pro Gln  Ser Gly Phe Gln Leu  Lys Gln Ser Lys Leu  Ser Ser Ile 
    2705                 2710                 2715             


Arg Leu  Lys Phe Glu Gln Gly  Xaa His Ala Lys Ser  Lys Asp Met 
    2720                 2725                 2730             


Ser Gln  Glu Asp Arg Lys Ser  Asp Gly Gln Ser Arg  Ile Pro Val 
    2735                 2740                 2745             


Lys Lys  Ile Gln Glu Ser Lys  Leu Pro Val Tyr Gln  Val Phe Ala 
    2750                 2755                 2760             


Arg Glu  Lys Gln Gln Lys Ala  Ile Asp Leu Pro Asp  Glu Ser Val 
    2765                 2770                 2775             


Ser Val  Gln Lys Asp Phe Met  Val Leu Lys Xaa Lys  Asp Glu His 
    2780                 2785                 2790             


Ala Gln  Ser Asn Glu Ile Val  Val Asn Asp Ser Gly  Ser Asp Asn 
    2795                 2800                 2805             


Val Lys  Lys Gln Arg Xaa Glu  Met Ser Ser Lys Ala  Met Pro Asp 
    2810                 2815                 2820             


Ser Phe  Ser Glu Gln Gln Ala  Lys Asp Leu Ala Cys  His Ile Xaa 
    2825                 2830                 2835             


Ser Asp  Leu Ala Xaa Arg Gly  Pro Trp Asp Lys Lys  Val Phe Arg 
    2840                 2845                 2850             


Xaa Trp  Glu Ser Ser Gly Ala  Xaa Asn Asn Lys Ser  Gln Lys Glu 
    2855                 2860                 2865             


Lys Leu  Ser His Val Leu Val  His Asp Val Arg Glu  Asn His Ile 
    2870                 2875                 2880             


Gly His  Pro Glu Ser Lys Ser  Val Asp Gln Lys Asn  Glu Phe Met 
    2885                 2890                 2895             


Ser Val  Xaa Glu Arg Glu Arg  Lys Leu Leu Xaa Asn  Gly Ser Leu 
    2900                 2905                 2910             


Ser Glu  Ile Lys Glu Met Xaa  Val Lys Ser Pro Ser  Lys Lys Val 
    2915                 2920                 2925             


Leu Tyr  Arg Glu Tyr Val Val  Lys Glu Gly Asp His  Pro Gly Gly 
    2930                 2935                 2940             


Leu Leu  Asp Gln Pro Ser Arg  Arg Ser Glu Ser Ser  Ala Val Ser 
    2945                 2950                 2955             


His Ile  Pro Val Arg Val Ala  Asp Glu Arg Arg Met  Leu Ser Ser 
    2960                 2965                 2970             


Asn Ile  Pro Asp Gly Phe Cys  Glu Gln Ser Ala Phe  Pro Lys His 
    2975                 2980                 2985             


Glu Leu  Ser Gln Lys Leu Ser  Gln Ser Ser Met Ser  Lys Glu Xaa 
    2990                 2995                 3000             


Val Glu  Xaa Gln His Phe Asn  Ser Ile Glu Asp Glu  Lys Val Xaa 
    3005                 3010                 3015             


Tyr Ser  Glu Ile Ser Lys Val  Ser Lys His Gln Ser  Tyr Val Gly 
    3020                 3025                 3030             


Leu Cys  Pro Pro Leu Glu Glu  Xaa Glu Xaa Ser Pro  Xaa Lys Ser 
    3035                 3040                 3045             


Pro Asp  Ser Leu Glu Phe Ser  Pro Gly Lys Glu Ser  Pro Ser Ser 
    3050                 3055                 3060             


Asp Val  Phe Asp His Ser Pro  Ile Asp Gly Leu Glu  Lys Leu Ala 
    3065                 3070                 3075             


Pro Leu  Ala Gln Xaa Glu Gly  Gly Lys Glu Ile Lys  Xaa Leu Pro 
    3080                 3085                 3090             


Val Tyr  Val Ser Phe Val Gln  Val Gly Lys Gln Tyr  Glu Lys Glu 
    3095                 3100                 3105             


Ile Gln  Gln Gly Gly Val Lys  Lys Ile Ile Ser Gln  Glu Cys Lys 
    3110                 3115                 3120             


Xaa Val  Gln Glu Xaa Arg Gly  Xaa Phe Tyr Xaa Xaa  Arg Gln Gln 
    3125                 3130                 3135             


Lys Gln  Pro Pro Ser Pro Gln  Gly Ser Pro Glu Asp  Asp Xaa Leu 
    3140                 3145                 3150             


Glu Gln  Val Ser Phe Leu Asp  Ser Ser Gly Lys Ser  Pro Leu Xaa 
    3155                 3160                 3165             


Pro Glu  Xaa Pro Ser Ser Glu  Glu Val Ser Tyr Glu  Phe Xaa Ser 
    3170                 3175                 3180             


Lys Xaa  Pro Asp Ser Leu Ile  Ala Tyr Ile Pro Gly  Lys Pro Ser 
    3185                 3190                 3195             


Pro Ile  Pro Glu Val Ser Glu  Glu Ser Glu Glu Glu  Glu Gln Ala 
    3200                 3205                 3210             


Lys Ser  Xaa Ser Leu Lys Gln  Xaa Xaa Val Glu Glu  Xaa Ala Val 
    3215                 3220                 3225             


Glu Arg  Glu Met Pro Asn Asp  Val Ser Lys Asp Ser  Asn Gln Arg 
    3230                 3235                 3240             


Pro Lys  Asn Asn Arg Val Ala  Tyr Ile Glu Phe Pro  Pro Pro Pro 
    3245                 3250                 3255             


Pro Leu  Asp Ala Asp Gln Ile  Glu Ser Asp Lys Lys  His His Tyr 
    3260                 3265                 3270             


Leu Pro  Glu Lys Glu Val Asp  Met Ile Glu Val Asn  Leu Gln Asp 
    3275                 3280                 3285             


Glu His  Asp Lys Tyr Gln Leu  Ala Glu Pro Val Ile  Arg Val Gln 
    3290                 3295                 3300             


Pro Pro  Ser Pro Val Pro Pro  Gly Ala Asp Val Ser  Asp Ser Ser 
    3305                 3310                 3315             


Asp Asp  Glu Ser Ile Tyr Gln  Pro Val Pro Val Lys  Lys Tyr Xaa 
    3320                 3325                 3330             


Phe Lys  Leu Lys Glu Val Asp  Asp Glu Gln Lys Glu  Lys Pro Lys 
    3335                 3340                 3345             


Ala Ser  Ala Glu Lys Ala Ser  Asn Gln Lys Glu Leu  Glu Ser Asn 
    3350                 3355                 3360             


Gly Ser  Gly Lys Asp Asn Glu  Phe Gly Leu Gly Leu  Asp Ser Pro 
    3365                 3370                 3375             


Gln Asn  Glu Ile Ala Gln Asn  Gly Asn Asn Asp Gln  Ser Ile Xaa 
    3380                 3385                 3390             


Glu Cys  Ser Ile Ala Xaa Xaa  Ala Glu Phe Ser His  Asp Xaa Asp 
    3395                 3400                 3405             


Ala Xaa  Glu Ile Asp Ser Leu  Asp Gly Tyr Asp Leu  Gln Asp Glu 
    3410                 3415                 3420             


Asp Asp  Gly Leu Xaa Glu Ser  Asp Ser Lys Leu Pro  Ile Gln Ala 
    3425                 3430                 3435             


Met Glu  Ile Lys Lys Asp Ile  Trp Asn Xaa Glu Gly  Ile Leu Lys 
    3440                 3445                 3450             


Pro Ala  Asp Arg Ser Phe Ser  Gln Ser Lys Leu Glu  Val Ile Glu 
    3455                 3460                 3465             


Glu Glu  Gly Lys Val Gly Pro  Asp Glu Asp Lys Pro  Pro Ser Lys 
    3470                 3475                 3480             


Ser Ser  Ser Ser Glu Lys Xaa  Pro Asp Lys Xaa Asp  Gln Lys Ser 
    3485                 3490                 3495             


Gly Ala  Gln Phe Phe Xaa Leu  Glu Gly Arg His Pro  Asp Arg Ser 
    3500                 3505                 3510             


Val Phe  Pro Asp Xaa Tyr Phe  Ser Tyr Lys Val Asp  Glu Glu Phe 
    3515                 3520                 3525             


Ala Xaa  Pro Phe Lys Xaa Val  Ala Xaa Lys Gly Leu  Asp Phe Asp 
    3530                 3535                 3540             


Pro Trp  Ser Asn Asn Arg Gly  Asp Asp Glu Val Phe  Asp Ser Lys 
    3545                 3550                 3555             


Ser Arg  Glu Asp Glu Xaa Lys  Pro Phe Gly Leu Ala  Val Glu Asp 
    3560                 3565                 3570             


Arg Ser  Pro Ala Xaa Xaa Pro  Asp Xaa Xaa Pro Ala  Arg Xaa Pro 
    3575                 3580                 3585             


Xaa Asp  Glu Ser Xaa Pro Xaa  Ser Glu Pro Asn Pro  Phe Pro Phe 
    3590                 3595                 3600             


His Glu  Gly Lys Met Phe Glu  Met Xaa Arg Ser Gly  Ala Ile Asp 
    3605                 3610                 3615             


Met Ser  Lys Arg Asp Phe Val  Glu Glu Arg Leu Gln  Phe Phe Gln 
    3620                 3625                 3630             


Ile Gly  Glu His Xaa Ser Glu  Gly Lys Ser Gly Asp  Gln Gly Glu 
    3635                 3640                 3645             


Gly Asp  Lys Ser Met Val Xaa  Ala Xaa Pro Gln Pro  Gln Ser Gly 
    3650                 3655                 3660             


Asp Xaa  Xaa Val Glu Xaa Asn  Leu Glu Arg Asn Val  Glu Xaa Pro 
    3665                 3670                 3675             


Xaa Val  Glu Pro Asn Pro Ser  Ile Pro Xaa Ser Gly  Glu Cys Gln 
    3680                 3685                 3690             


Glu Gly  Xaa Ser Ser Ser Gly  Ser Leu Glu Lys Ser  Ala Ala Ala 
    3695                 3700                 3705             


Xaa Asn  Xaa Ser Lys Val Asp  Pro Lys Leu Arg Xaa  Pro Ile Lys 
    3710                 3715                 3720             


Met Gly  Ile Ser Ala Ser Xaa  Met Xaa Met Lys Lys  Glu Gly Pro 
    3725                 3730                 3735             


Gly Glu  Ile Xaa Asp Lys Ile  Glu Ala Val Met Xaa  Ser Cys Gln 
    3740                 3745                 3750             


Gly Leu  Glu Asn Glu Xaa Ile  Xaa Met Ile Ser Asn  Xaa Ala Asn 
    3755                 3760                 3765             


Ser Gln  Met Gly Val Arg Pro  His Glu Lys His Asp  Phe Gln Lys 
    3770                 3775                 3780             


Asp Asn  Phe Asn Asn Asn Asn  Asn Leu Asp Ser Ser  Xaa Ile Gln 
    3785                 3790                 3795             


Xaa Asp  Asn Ile Met Ser Asn  Ile Val Leu Xaa Glu  His Ser Ala 
    3800                 3805                 3810             


Pro Xaa  Cys Xaa Xaa Glu Lys  Asp Asn Pro Val Lys  Val Ser Ser 
    3815                 3820                 3825             


Gly Lys  Lys Xaa Gly Val Leu  Gln Gly His Cys Val  Arg Asp Lys 
    3830                 3835                 3840             


Gln Lys  Val Leu Gly Glu Gln  Gln Lys Xaa Lys Glu  Leu Ile Gly 
    3845                 3850                 3855             


Ile Arg  Gln Lys Ser Lys Leu  Pro Ile Lys Ala Xaa  Ser Pro Lys 
    3860                 3865                 3870             


Asp Xaa  Phe Pro Pro Asn His  Met Ser Asn Xaa Lys  Ala Ser Lys 
    3875                 3880                 3885             


Met Lys  Gln Val Ser Gln Ser  Glu Lys Xaa Lys Ala  Leu Xaa Xaa 
    3890                 3895                 3900             


Ser Ser  Cys Val Asp Val Lys  Ser Arg Ile Pro Val  Lys Asn Xaa 
    3905                 3910                 3915             


His Arg  Asp Asn Ile Ile Ala  Val Arg Lys Ala Cys  Ala Xaa Gln 
    3920                 3925                 3930             


Lys Gln  Gly Gln Pro Glu Lys  Gly Lys Ala Lys Gln  Leu Pro Ser 
    3935                 3940                 3945             


Lys Leu  Pro Val Lys Val Arg  Ser Xaa Cys Val Xaa  Xaa Xaa Xaa 
    3950                 3955                 3960             


Xaa Xaa  Ala Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    3965                 3970                 3975             


Ser Cys  Xaa Val Lys Val Arg  Lys Ser Gln Leu Lys  Glu Val Cys 
    3980                 3985                 3990             


Lys His  Ser Ile Glu Tyr Phe  Lys Gly Ile Ser Gly  Glu Xaa Leu 
    3995                 4000                 4005             


Lys Leu  Val Asp Arg Leu Ser  Glu Glu Glu Lys Lys  Met Gln Ser 
    4010                 4015                 4020             


Glu Leu  Ser Asp Glu Glu Glu  Ser Xaa Ser Arg Asn  Xaa Ser Leu 
    4025                 4030                 4035             


Ser Glu  Xaa Ser Arg Gly Gly  Gln Pro Ser Val Xaa  Xaa Lys Ser 
    4040                 4045                 4050             


Ala Arg  Asp Lys Lys Xaa Glu  Ala Ala Pro Leu Lys  Ser Lys Ser 
    4055                 4060                 4065             


Glu Lys  Ala Gly Ser Glu Lys  Arg Ser Ser Arg Arg  Xaa Gly Pro 
    4070                 4075                 4080             


Gln Ser  Pro Cys Glu Arg Xaa  Asp Ile Arg Met Ala  Ile Val Ala 
    4085                 4090                 4095             


Asp His  Leu Gly Leu Ser Trp  Xaa Glu Leu Ala Arg  Glu Leu Asn 
    4100                 4105                 4110             


Phe Ser  Val Asp Glu Ile Asn  Gln Ile Arg Val Glu  Asn Pro Asn 
    4115                 4120                 4125             


Ser Leu  Ile Ser Gln Ser Phe  Met Leu Leu Lys Lys  Trp Val Xaa 
    4130                 4135                 4140             


Arg Asp  Gly Lys Asn Ala Xaa  Xaa Asp Ala Leu Xaa  Ser Val Leu 
    4145                 4150                 4155             


Xaa Lys  Ile Asn Arg Ile Asp  Ile Val Xaa Leu Leu  Glu Gly Pro 
    4160                 4165                 4170             


Ile Phe  Asp Tyr Gly Asn Ile  Ser Gly Xaa Arg Ser  Phe Ala Asp 
    4175                 4180                 4185             


Glu Asn  Asn Val Phe His Asp  Pro Val Asp Gly Trp  Gln Asn Glu 
    4190                 4195                 4200             


Xaa Ser  Ser Gly Asn Leu Glu  Ser Cys Ala Gln Ala  Arg Arg Val 
    4205                 4210                 4215             


Xaa Gly  Gly Leu Leu Asp Arg  Leu Asp Asp Ser Pro  Asp Gln Cys 
    4220                 4225                 4230             


Arg Asp  Ser Ile Xaa Ser Tyr  Leu Lys Gly Glu Ala  Gly Lys Phe 
    4235                 4240                 4245             


Glu Ala  Asn Gly Ser His Xaa  Glu Ile Xaa Pro Glu  Ala Lys Xaa 
    4250                 4255                 4260             


Lys Ser  Tyr Phe Pro Glu Ser  Gln Asn Asp Val Gly  Lys Gln Ser 
    4265                 4270                 4275             


Xaa Lys  Glu Xaa Leu Lys Pro  Lys Ile His Gly Ser  Gly His Val 
    4280                 4285                 4290             


Glu Glu  Pro Ala Ser Pro Leu  Ala Ala Tyr Gln Lys  Ser Leu Glu 
    4295                 4300                 4305             


Glu Xaa  Ser Lys Leu Ile Ile  Glu Glu Xaa Lys Pro  Cys Val Pro 
    4310                 4315                 4320             


Val Ser  Met Lys Lys Met Ser  Arg Xaa Ser Pro Ala  Asp Gly Lys 
    4325                 4330                 4335             


Pro Arg  Leu Ser Leu His Glu  Glu Glu Gly Ser Ser  Gly Ser Glu 
    4340                 4345                 4350             


Gln Lys  Gln Gly Glu Gly Phe  Lys Val Lys Xaa Lys  Lys Glu Ile 
    4355                 4360                 4365             


Arg His  Val Glu Lys Lys Ser  His Ser 
    4370                 4375         


<210> 2316
<211> 1001
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<400> 2316
Met Ala Leu Pro Gln Ser Glu Asp Ala Met Xaa Gly Asp Xaa Asp Lys 
1               5                   10                  15      


Tyr Leu Gly Pro Gln Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro 
            20                  25                  30          


Ala Glu Gly Tyr Met Gly Phe Ser Leu Gly Ala Arg Ser Ala Ser Leu 
        35                  40                  45              


Arg Ser Phe Ser Ser Asp Arg Ser Tyr Xaa Leu Asn Arg Ser Ser Tyr 
    50                  55                  60                  


Ala Arg Asp Ser Met Met Ile Glu Glu Leu Leu Val Pro Ser Lys Glu 
65                  70                  75                  80  


Gln His Leu Xaa Phe Xaa Arg Glu Phe Asp Ser Asp Ser Leu Arg His 
                85                  90                  95      


Tyr Ser Trp Ala Ala Asp Xaa Leu Asp Asn Val Asn Leu Val Ser Ser 
            100                 105                 110         


Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly 
        115                 120                 125             


Gly Ser Met Arg Gly Ser Arg His His Gly Met Arg Ile Ile Ile Pro 
    130                 135                 140                 


Pro Arg Lys Cys Xaa Ala Pro Xaa Arg Ile Xaa Cys Arg Leu Val Lys 
145                 150                 155                 160 


Arg His Lys Leu Ala Asn Pro Pro Pro Met Val Glu Gly Glu Gly Leu 
                165                 170                 175     


Ala Ser Arg Leu Val Glu Met Gly Pro Ala Gly Ala Gln Phe Leu Gly 
            180                 185                 190         


Pro Val Ile Val Glu Ile Pro His Phe Gly Ser Met Arg Gly Lys Glu 
        195                 200                 205             


Arg Glu Leu Ile Val Leu Arg Ser Glu Asn Gly Glu Xaa Trp Lys Glu 
    210                 215                 220                 


His Gln Phe Asp Ser Lys Asn Glu Asp Leu Xaa Glu Leu Leu Asn Gly 
225                 230                 235                 240 


Met Asp Glu Glu Leu Asp Ser Pro Glu Glu Leu Gly Lys Lys Arg Ile 
                245                 250                 255     


Cys Arg Ile Ile Xaa Lys Asp Phe Pro Gln Tyr Phe Ala Val Val Ser 
            260                 265                 270         


Arg Ile Lys Gln Glu Ser Asn Gln Ile Gly Pro Glu Gly Gly Ile Leu 
        275                 280                 285             


Ser Ser Xaa Xaa Val Pro Leu Val Gln Ala Ser Phe Pro Glu Gly Ala 
    290                 295                 300                 


Leu Xaa Lys Arg Ile Arg Val Gly Leu Gln Ala Gln Pro Val Pro Asp 
305                 310                 315                 320 


Glu Ile Val Lys Lys Ile Leu Gly Asn Lys Ala Xaa Phe Ser Pro Ile 
                325                 330                 335     


Val Xaa Val Glu Pro Arg Arg Arg Lys Phe His Lys Pro Ile Xaa Met 
            340                 345                 350         


Xaa Ile Pro Val Pro Pro Pro Ser Gly Glu Gly Val Ser Asn Gly Tyr 
        355                 360                 365             


Lys Gly Asp Xaa Xaa Pro Asn Leu Arg Leu Leu Cys Ser Ile Xaa Gly 
    370                 375                 380                 


Gly Xaa Ser Pro Ala Gln Trp Glu Asp Ile Xaa Gly Xaa Xaa Pro Leu 
385                 390                 395                 400 


Xaa Phe Ile Lys Asp Cys Val Ser Phe Xaa Xaa Asn Val Ser Ala Arg 
                405                 410                 415     


Phe Trp Leu Ala Asp Cys His Gln Val Leu Glu Xaa Val Gly Leu Ala 
            420                 425                 430         


Xaa Gln Leu Tyr Arg Glu Leu Ile Cys Val Pro Tyr Met Ala Lys Phe 
        435                 440                 445             


Val Val Phe Ala Lys Met Asn Asp Pro Val Glu Ser Ser Leu Arg Cys 
    450                 455                 460                 


Phe Cys Met Xaa Asp Asp Lys Val Asp Lys Xaa Leu Glu Gln Gln Glu 
465                 470                 475                 480 


Asn Phe Glu Glu Val Ala Arg Ser Lys Asp Ile Glu Val Leu Glu Gly 
                485                 490                 495     


Lys Pro Ile Tyr Val Asp Cys Tyr Gly Asn Leu Ala Pro Leu Xaa Lys 
            500                 505                 510         


Gly Gly Gln Gln Leu Val Phe Asn Phe Tyr Ser Phe Lys Glu Asn Arg 
        515                 520                 525             


Leu Pro Phe Ser Ile Lys Ile Arg Asp Xaa Ser Gln Glu Pro Cys Gly 
    530                 535                 540                 


Arg Leu Ser Phe Leu Lys Glu Pro Lys Xaa Xaa Lys Gly Leu Pro Gln 
545                 550                 555                 560 


Xaa Ala Val Cys Asn Leu Asn Ile Xaa Leu Pro Ala His Lys Lys Ile 
                565                 570                 575     


Glu Lys Xaa Asp Arg Arg Gln Ser Phe Ala Ser Leu Ala Leu Arg Lys 
            580                 585                 590         


Arg Tyr Ser Tyr Leu Xaa Glu Pro Gly Met Ser Pro Gln Ser Pro Cys 
        595                 600                 605             


Glu Arg Xaa Asp Ile Arg Met Ala Ile Val Ala Asp His Leu Gly Leu 
    610                 615                 620                 


Ser Trp Xaa Glu Leu Ala Arg Glu Leu Asn Phe Ser Val Asp Glu Ile 
625                 630                 635                 640 


Asn Gln Ile Arg Val Glu Asn Pro Asn Ser Leu Ile Ser Gln Ser Phe 
                645                 650                 655     


Met Leu Leu Lys Lys Trp Val Xaa Arg Asp Gly Lys Asn Ala Xaa Xaa 
            660                 665                 670         


Asp Ala Leu Xaa Ser Val Leu Xaa Lys Ile Asn Arg Ile Asp Ile Val 
        675                 680                 685             


Xaa Leu Leu Glu Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser Gly Xaa 
    690                 695                 700                 


Arg Ser Phe Ala Asp Glu Asn Asn Val Phe His Asp Pro Val Asp Gly 
705                 710                 715                 720 


Tyr Pro Ser Leu Gln Val Glu Leu Glu Xaa Pro Xaa Gly Leu His Tyr 
                725                 730                 735     


Xaa Pro Pro Xaa Pro Phe Gln Gln Asp Asp Tyr Phe Ser Asp Ile Ser 
            740                 745                 750         


Ser Ile Glu Ser Pro Leu Arg Xaa Pro Ser Arg Leu Ser Asp Gly Leu 
        755                 760                 765             


Val Pro Ser Gln Gly Asn Ile Glu His Ser Ala Asp Gly Pro Pro Val 
    770                 775                 780                 


Val Xaa Ala Glu Asp Ala Ser Leu Glu Asp Ser Lys Leu Glu Asp Ser 
785                 790                 795                 800 


Val Pro Leu Xaa Glu Met Pro Glu Ala Val Asp Val Asp Glu Ser Gln 
                805                 810                 815     


Leu Glu Asn Val Cys Leu Ser Trp Gln Asn Glu Xaa Ser Ser Gly Asn 
            820                 825                 830         


Leu Glu Ser Cys Ala Gln Ala Arg Arg Val Xaa Gly Gly Leu Leu Asp 
        835                 840                 845             


Arg Leu Asp Asp Ser Pro Asp Gln Cys Arg Asp Ser Ile Xaa Ser Tyr 
    850                 855                 860                 


Leu Lys Gly Glu Ala Gly Lys Phe Glu Ala Asn Gly Ser His Xaa Glu 
865                 870                 875                 880 


Ile Xaa Pro Glu Ala Lys Xaa Lys Ser Tyr Phe Pro Glu Ser Gln Asn 
                885                 890                 895     


Asp Val Gly Lys Gln Ser Xaa Lys Glu Xaa Leu Lys Pro Lys Ile His 
            900                 905                 910         


Gly Ser Gly His Val Glu Glu Pro Ala Ser Pro Leu Ala Ala Tyr Gln 
        915                 920                 925             


Lys Ser Leu Glu Glu Xaa Ser Lys Leu Ile Ile Glu Glu Xaa Lys Pro 
    930                 935                 940                 


Cys Val Pro Val Ser Met Lys Lys Met Ser Arg Xaa Ser Pro Ala Asp 
945                 950                 955                 960 


Gly Lys Pro Arg Leu Ser Leu His Glu Glu Glu Gly Ser Ser Gly Ser 
                965                 970                 975     


Glu Gln Lys Gln Gly Glu Gly Phe Lys Val Lys Xaa Lys Lys Glu Ile 
            980                 985                 990         


Arg His Val Glu Lys Lys Ser His  Ser 
        995                 1000     


<210> 2317
<211> 1861
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1211)..(1211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1213)..(1213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1243)..(1243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1246)..(1246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1255)..(1255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1270)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1293)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1328)..(1328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1398)..(1398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1421)..(1421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1429)..(1429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1439)..(1439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1471)..(1471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1487)..(1487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1524)..(1524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1531)..(1532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1536)..(1536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1540)..(1540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1549)..(1549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1564)..(1564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1590)..(1590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1592)..(1592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1597)..(1597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1600)..(1600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1620)..(1620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1664)..(1664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1688)..(1688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1703)..(1703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1722)..(1722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1739)..(1739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1742)..(1742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1747)..(1747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1763)..(1763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1766)..(1766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1794)..(1794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1802)..(1802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1816)..(1816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1848)..(1848)
<223> Selenocysteine

<400> 2317
Met Ala Ser Ser Ala Ser Ser Ser Pro Ala Gly Xaa Glu Asp Ser Ala 
1               5                   10                  15      


Pro Ala Gln Gly Gly Phe Gly Ser Asp Tyr Ser Arg Ser Ser Arg Lys 
            20                  25                  30          


Ser Asp Ala Asn Ala Ser Tyr Leu Arg Ala Ala Arg Ala Gly His Leu 
        35                  40                  45              


Glu Lys Ala Leu Asp Tyr Ile Lys Asn Gly Val Asp Ile Asn Ile Cys 
    50                  55                  60                  


Asn Gln Asn Gly Leu Asn Ala Leu His Leu Ala Ser Lys Glu Gly His 
65                  70                  75                  80  


Val Glu Val Val Ser Glu Leu Leu Gln Arg Glu Ala Asn Val Asp Ala 
                85                  90                  95      


Ala Xaa Lys Lys Gly Asn Xaa Ala Leu His Ile Ala Ser Leu Ala Gly 
            100                 105                 110         


Gln Ala Glu Val Val Lys Val Leu Val Xaa Asn Gly Ala Asn Val Asn 
        115                 120                 125             


Ala Gln Ser Gln Asn Gly Phe Xaa Pro Leu Tyr Met Ala Ala Gln Glu 
    130                 135                 140                 


Asn His Leu Glu Val Val Lys Phe Leu Leu Asp Asn Gly Ala Ser Gln 
145                 150                 155                 160 


Ser Leu Ala Xaa Glu Asp Gly Phe Xaa Pro Leu Ala Val Ala Leu Gln 
                165                 170                 175     


Gln Gly His Asp Gln Val Val Ser Leu Leu Leu Glu Asn Asp Xaa Lys 
            180                 185                 190         


Gly Lys Val Arg Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp 
        195                 200                 205             


Xaa Lys Ala Ala Ala Leu Leu Leu Gln Asn Asp Asn Asn Ala Asp Val 
    210                 215                 220                 


Glu Ser Lys Ser Gly Phe Xaa Pro Leu His Ile Ala Ala His Tyr Gly 
225                 230                 235                 240 


Asn Ile Asn Val Ala Xaa Leu Leu Leu Asn Arg Ala Ala Ala Val Asp 
                245                 250                 255     


Phe Xaa Ala Arg Asn Asp Ile Xaa Pro Leu His Val Ala Ser Lys Arg 
            260                 265                 270         


Gly Asn Ala Asn Met Val Lys Leu Leu Leu Asp Arg Gly Ala Lys Ile 
        275                 280                 285             


Asp Ala Lys Xaa Arg Asp Gly Leu Xaa Pro Leu His Cys Gly Ala Arg 
    290                 295                 300                 


Ser Gly His Glu Gln Val Val Glu Met Leu Leu Asp Arg Ala Ala Pro 
305                 310                 315                 320 


Ile Leu Ser Lys Xaa Lys Asn Gly Leu Ser Pro Leu His Met Ala Xaa 
                325                 330                 335     


Gln Gly Asp His Leu Asn Cys Val Gln Leu Leu Leu Gln His Asn Val 
            340                 345                 350         


Pro Val Asp Asp Val Xaa Asn Asp Tyr Leu Xaa Ala Leu His Val Ala 
        355                 360                 365             


Ala His Cys Gly His Tyr Lys Val Ala Lys Val Leu Leu Asp Lys Lys 
    370                 375                 380                 


Ala Asn Pro Asn Ala Lys Ala Leu Asn Gly Phe Xaa Pro Leu His Ile 
385                 390                 395                 400 


Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu Leu Leu Lys His 
                405                 410                 415     


Gly Ala Ser Ile Gln Ala Val Xaa Glu Ser Gly Leu Xaa Pro Ile His 
            420                 425                 430         


Val Ala Ala Phe Met Gly His Val Asn Ile Val Ser Gln Leu Met His 
        435                 440                 445             


His Gly Ala Ser Pro Asn Xaa Xaa Asn Val Arg Gly Glu Xaa Ala Leu 
    450                 455                 460                 


His Met Ala Ala Arg Ser Gly Gln Ala Glu Val Val Arg Tyr Leu Val 
465                 470                 475                 480 


Gln Asp Gly Ala Gln Val Glu Ala Lys Ala Lys Asp Asp Gln Xaa Pro 
                485                 490                 495     


Leu His Ile Ser Ala Arg Leu Gly Lys Ala Asp Ile Val Gln Gln Leu 
            500                 505                 510         


Leu Gln Gln Gly Ala Ser Pro Asn Ala Ala Xaa Xaa Ser Gly Tyr Xaa 
        515                 520                 525             


Pro Leu His Leu Ser Ala Arg Glu Gly His Glu Asp Val Ala Ala Phe 
    530                 535                 540                 


Leu Leu Asp His Gly Ala Ser Leu Ser Ile Xaa Xaa Lys Lys Gly Phe 
545                 550                 555                 560 


Xaa Pro Leu His Val Ala Ala Lys Tyr Gly Lys Leu Glu Val Ala Asn 
                565                 570                 575     


Leu Leu Leu Gln Lys Ser Ala Ser Pro Asp Ala Ala Gly Lys Ser Gly 
            580                 585                 590         


Leu Xaa Pro Leu His Val Ala Ala His Tyr Asp Asn Gln Lys Val Ala 
        595                 600                 605             


Leu Leu Leu Leu Asp Gln Gly Ala Ser Pro His Ala Ala Ala Lys Asn 
    610                 615                 620                 


Gly Tyr Xaa Pro Leu His Ile Ala Ala Lys Lys Asn Gln Met Asp Ile 
625                 630                 635                 640 


Ala Xaa Xaa Leu Leu Glu Tyr Gly Ala Asp Ala Asn Ala Val Xaa Arg 
                645                 650                 655     


Gln Gly Ile Ala Ser Val His Leu Ala Ala Gln Glu Gly His Val Asp 
            660                 665                 670         


Met Val Ser Leu Leu Leu Gly Arg Asn Ala Asn Val Asn Leu Ser Asn 
        675                 680                 685             


Lys Ser Gly Leu Xaa Pro Leu His Leu Ala Ala Gln Glu Asp Arg Val 
    690                 695                 700                 


Asn Val Ala Glu Val Leu Val Asn Gln Gly Ala His Val Asp Ala Gln 
705                 710                 715                 720 


Xaa Lys Met Gly Tyr Xaa Pro Leu His Val Gly Cys His Tyr Gly Asn 
                725                 730                 735     


Ile Lys Ile Val Asn Phe Leu Leu Gln His Ser Ala Lys Val Asn Ala 
            740                 745                 750         


Lys Xaa Lys Asn Gly Tyr Xaa Pro Leu His Gln Ala Ala Gln Gln Gly 
        755                 760                 765             


His Xaa His Ile Ile Asn Val Leu Leu Gln Asn Asn Ala Ser Pro Asn 
    770                 775                 780                 


Glu Leu Xaa Val Asn Gly Asn Xaa Ala Leu Gly Ile Ala Arg Arg Leu 
785                 790                 795                 800 


Gly Tyr Ile Ser Val Val Asp Xaa Leu Lys Ile Val Xaa Glu Glu Xaa 
                805                 810                 815     


Met Xaa Xaa Xaa Xaa Val Xaa Glu Lys His Lys Met Asn Val Pro Glu 
            820                 825                 830         


Xaa Met Asn Glu Val Leu Asp Met Ser Asp Asp Glu Val Arg Lys Ala 
        835                 840                 845             


Asn Ala Pro Glu Met Leu Ser Asp Gly Glu Tyr Ile Ser Asp Val Glu 
    850                 855                 860                 


Glu Gly Glu Asp Ala Met Xaa Gly Asp Xaa Asp Lys Tyr Leu Gly Pro 
865                 870                 875                 880 


Gln Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ala Glu Gly Tyr 
                885                 890                 895     


Met Gly Phe Ser Leu Gly Ala Arg Ser Ala Ser Leu Arg Ser Phe Ser 
            900                 905                 910         


Ser Asp Arg Ser Tyr Xaa Leu Asn Arg Ser Ser Tyr Ala Arg Asp Ser 
        915                 920                 925             


Met Met Ile Glu Glu Leu Leu Val Pro Ser Lys Glu Gln His Leu Xaa 
    930                 935                 940                 


Phe Xaa Arg Glu Phe Asp Ser Asp Ser Leu Arg His Tyr Ser Trp Ala 
945                 950                 955                 960 


Ala Asp Xaa Leu Asp Asn Val Asn Leu Val Ser Ser Pro Ile His Ser 
                965                 970                 975     


Gly Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg 
            980                 985                 990         


Gly Ser Arg His His Gly Met Arg  Ile Ile Ile Pro Pro  Arg Lys Cys 
        995                 1000                 1005             


Xaa Ala  Pro Xaa Arg Ile Xaa  Cys Arg Leu Val Lys  Arg His Lys 
    1010                 1015                 1020             


Leu Ala  Asn Pro Pro Pro Met  Val Glu Gly Glu Gly  Leu Ala Ser 
    1025                 1030                 1035             


Arg Leu  Val Glu Met Gly Pro  Ala Gly Ala Gln Phe  Leu Gly Pro 
    1040                 1045                 1050             


Val Ile  Val Glu Ile Pro His  Phe Gly Ser Met Arg  Gly Lys Glu 
    1055                 1060                 1065             


Arg Glu  Leu Ile Val Leu Arg  Ser Glu Asn Gly Glu  Xaa Trp Lys 
    1070                 1075                 1080             


Glu His  Gln Phe Asp Ser Lys  Asn Glu Asp Leu Xaa  Glu Leu Leu 
    1085                 1090                 1095             


Asn Gly  Met Asp Glu Glu Leu  Asp Ser Pro Glu Glu  Leu Gly Lys 
    1100                 1105                 1110             


Lys Arg  Ile Cys Arg Ile Ile  Xaa Lys Asp Phe Pro  Gln Tyr Phe 
    1115                 1120                 1125             


Ala Val  Val Ser Arg Ile Lys  Gln Glu Ser Asn Gln  Ile Gly Pro 
    1130                 1135                 1140             


Glu Gly  Gly Ile Leu Ser Ser  Xaa Xaa Val Pro Leu  Val Gln Ala 
    1145                 1150                 1155             


Ser Phe  Pro Glu Gly Ala Leu  Xaa Lys Arg Ile Arg  Val Gly Leu 
    1160                 1165                 1170             


Gln Ala  Gln Pro Val Pro Asp  Glu Ile Val Lys Lys  Ile Leu Gly 
    1175                 1180                 1185             


Asn Lys  Ala Xaa Phe Ser Pro  Ile Val Xaa Val Glu  Pro Arg Arg 
    1190                 1195                 1200             


Arg Lys  Phe His Lys Pro Ile  Xaa Met Xaa Ile Pro  Val Pro Pro 
    1205                 1210                 1215             


Pro Ser  Gly Glu Gly Val Ser  Asn Gly Tyr Lys Gly  Asp Xaa Xaa 
    1220                 1225                 1230             


Pro Asn  Leu Arg Leu Leu Cys  Ser Ile Xaa Gly Gly  Xaa Ser Pro 
    1235                 1240                 1245             


Ala Gln  Trp Glu Asp Ile Xaa  Gly Xaa Xaa Pro Leu  Xaa Phe Ile 
    1250                 1255                 1260             


Lys Asp  Cys Val Ser Phe Xaa  Xaa Asn Val Ser Ala  Arg Phe Trp 
    1265                 1270                 1275             


Leu Ala  Asp Cys His Gln Val  Leu Glu Xaa Val Gly  Leu Ala Xaa 
    1280                 1285                 1290             


Gln Leu  Tyr Arg Glu Leu Ile  Cys Val Pro Tyr Met  Ala Lys Phe 
    1295                 1300                 1305             


Val Val  Phe Ala Lys Met Asn  Asp Pro Val Glu Ser  Ser Leu Arg 
    1310                 1315                 1320             


Cys Phe  Cys Met Xaa Asp Asp  Lys Val Asp Lys Xaa  Leu Glu Gln 
    1325                 1330                 1335             


Gln Glu  Asn Phe Glu Glu Val  Ala Arg Ser Lys Asp  Ile Glu Val 
    1340                 1345                 1350             


Leu Glu  Gly Lys Pro Ile Tyr  Val Asp Cys Tyr Gly  Asn Leu Ala 
    1355                 1360                 1365             


Pro Leu  Xaa Lys Gly Gly Gln  Gln Leu Val Phe Asn  Phe Tyr Ser 
    1370                 1375                 1380             


Phe Lys  Glu Asn Arg Leu Pro  Phe Ser Ile Lys Ile  Arg Asp Xaa 
    1385                 1390                 1395             


Ser Gln  Glu Pro Cys Gly Arg  Leu Ser Phe Leu Lys  Glu Pro Lys 
    1400                 1405                 1410             


Xaa Xaa  Lys Gly Leu Pro Gln  Xaa Ala Val Cys Asn  Leu Asn Ile 
    1415                 1420                 1425             


Xaa Leu  Pro Ala His Lys Lys  Ile Glu Lys Xaa Asp  Arg Arg Gln 
    1430                 1435                 1440             


Ser Phe  Ala Ser Leu Ala Leu  Arg Lys Arg Tyr Ser  Tyr Leu Xaa 
    1445                 1450                 1455             


Glu Pro  Gly Met Ser Pro Gln  Ser Pro Cys Glu Arg  Xaa Asp Ile 
    1460                 1465                 1470             


Arg Met  Ala Ile Val Ala Asp  His Leu Gly Leu Ser  Trp Xaa Glu 
    1475                 1480                 1485             


Leu Ala  Arg Glu Leu Asn Phe  Ser Val Asp Glu Ile  Asn Gln Ile 
    1490                 1495                 1500             


Arg Val  Glu Asn Pro Asn Ser  Leu Ile Ser Gln Ser  Phe Met Leu 
    1505                 1510                 1515             


Leu Lys  Lys Trp Val Xaa Arg  Asp Gly Lys Asn Ala  Xaa Xaa Asp 
    1520                 1525                 1530             


Ala Leu  Xaa Ser Val Leu Xaa  Lys Ile Asn Arg Ile  Asp Ile Val 
    1535                 1540                 1545             


Xaa Leu  Leu Glu Gly Pro Ile  Phe Asp Tyr Gly Asn  Ile Ser Gly 
    1550                 1555                 1560             


Xaa Arg  Ser Phe Ala Asp Glu  Asn Asn Val Phe His  Asp Pro Val 
    1565                 1570                 1575             


Asp Gly  Tyr Pro Ser Leu Gln  Val Glu Leu Glu Xaa  Pro Xaa Gly 
    1580                 1585                 1590             


Leu His  Tyr Xaa Pro Pro Xaa  Pro Phe Gln Gln Asp  Asp Tyr Phe 
    1595                 1600                 1605             


Ser Asp  Ile Ser Ser Ile Glu  Ser Pro Leu Arg Xaa  Pro Ser Arg 
    1610                 1615                 1620             


Leu Ser  Asp Gly Leu Val Pro  Ser Gln Gly Asn Ile  Glu His Ser 
    1625                 1630                 1635             


Ala Asp  Gly Pro Pro Val Val  Xaa Ala Glu Asp Ala  Ser Leu Glu 
    1640                 1645                 1650             


Asp Ser  Lys Leu Glu Asp Ser  Val Pro Leu Xaa Glu  Met Pro Glu 
    1655                 1660                 1665             


Ala Val  Asp Val Asp Glu Ser  Gln Leu Glu Asn Val  Cys Leu Ser 
    1670                 1675                 1680             


Trp Gln  Asn Glu Xaa Ser Ser  Gly Asn Leu Glu Ser  Cys Ala Gln 
    1685                 1690                 1695             


Ala Arg  Arg Val Xaa Gly Gly  Leu Leu Asp Arg Leu  Asp Asp Ser 
    1700                 1705                 1710             


Pro Asp  Gln Cys Arg Asp Ser  Ile Xaa Ser Tyr Leu  Lys Gly Glu 
    1715                 1720                 1725             


Ala Gly  Lys Phe Glu Ala Asn  Gly Ser His Xaa Glu  Ile Xaa Pro 
    1730                 1735                 1740             


Glu Ala  Lys Xaa Lys Ser Tyr  Phe Pro Glu Ser Gln  Asn Asp Val 
    1745                 1750                 1755             


Gly Lys  Gln Ser Xaa Lys Glu  Xaa Leu Lys Pro Lys  Ile His Gly 
    1760                 1765                 1770             


Ser Gly  His Val Glu Glu Pro  Ala Ser Pro Leu Ala  Ala Tyr Gln 
    1775                 1780                 1785             


Lys Ser  Leu Glu Glu Xaa Ser  Lys Leu Ile Ile Glu  Glu Xaa Lys 
    1790                 1795                 1800             


Pro Cys  Val Pro Val Ser Met  Lys Lys Met Ser Arg  Xaa Ser Pro 
    1805                 1810                 1815             


Ala Asp  Gly Lys Pro Arg Leu  Ser Leu His Glu Glu  Glu Gly Ser 
    1820                 1825                 1830             


Ser Gly  Ser Glu Gln Lys Gln  Gly Glu Gly Phe Lys  Val Lys Xaa 
    1835                 1840                 1845             


Lys Lys  Glu Ile Arg His Val  Glu Lys Lys Ser His  Ser 
    1850                 1855                 1860     


<210> 2318
<211> 273
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<400> 2318
Met Ala Val Glu Glu Gly Glu Ser Phe Pro Glu Gln Ser Asp Ala Asn 
1               5                   10                  15      


Ala Ser Tyr Leu Arg Ala Ala Arg Ala Gly His Leu Glu Lys Ala Leu 
            20                  25                  30          


Asp Tyr Ile Lys Asn Gly Val Asp Ile Asn Ile Cys Asn Gln Asn Gly 
        35                  40                  45              


Leu Asn Ala Leu His Leu Ala Ser Lys Glu Gly His Val Glu Val Val 
    50                  55                  60                  


Ser Glu Leu Leu Gln Arg Glu Ala Asn Val Asp Ala Ala Xaa Lys Lys 
65                  70                  75                  80  


Gly Asn Xaa Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val 
                85                  90                  95      


Val Lys Val Leu Val Xaa Asn Gly Ala Asn Val Asn Ala Gln Ser Gln 
            100                 105                 110         


Asn Gly Phe Xaa Pro Leu Tyr Met Ala Ala Gln Glu Asn His Leu Glu 
        115                 120                 125             


Val Val Lys Phe Leu Leu Asp Asn Gly Ala Ser Gln Ser Leu Ala Xaa 
    130                 135                 140                 


Glu Asp Gly Phe Xaa Pro Leu Ala Val Ala Leu Gln Gln Gly His Asp 
145                 150                 155                 160 


Gln Val Val Ser Leu Leu Leu Glu Asn Asp Xaa Lys Gly Lys Val Arg 
                165                 170                 175     


Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp Xaa Lys Ala Ala 
            180                 185                 190         


Ala Leu Leu Leu Gln Asn Asp Asn Asn Ala Asp Val Glu Ser Lys Ser 
        195                 200                 205             


Gly Phe Xaa Pro Leu His Ile Ala Ala His Tyr Gly Asn Ile Asn Val 
    210                 215                 220                 


Ala Xaa Leu Leu Leu Asn Arg Ala Ala Ala Val Asp Phe Xaa Ala Arg 
225                 230                 235                 240 


Asn Asp Ile Xaa Pro Leu His Val Ala Ser Lys Arg Gly Asn Ala Asn 
                245                 250                 255     


Met Val Lys Leu Leu Leu Asp Arg Gly Ala Lys Ile Asp Ala Lys Xaa 
            260                 265                 270         


Arg 
    


<210> 2319
<211> 86
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<400> 2319
Met Asn Val Pro Glu Xaa Met Asn Glu Val Leu Asp Met Ser Asp Asp 
1               5                   10                  15      


Glu Gly Asn Arg Cys Xaa Trp Tyr Lys Ile Pro Lys Val Gln Glu Phe 
            20                  25                  30          


Xaa Val Lys Ser Glu Asp Ala Met Xaa Gly Asp Xaa Asp Lys Tyr Leu 
        35                  40                  45              


Gly Pro Gln Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ala Glu 
    50                  55                  60                  


Gly Tyr Met Gly Phe Ser Leu Gly Ala Arg Ser Ala Arg Tyr Phe Val 
65                  70                  75                  80  


Val Ala Val Phe His Ser 
                85      


<210> 2320
<211> 450
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(445)
<223> Selenocysteine

<400> 2320
Met Ser Glu Glu Pro Lys Glu Lys Asn Ala Lys Pro Ala His Arg Lys 
1               5                   10                  15      


Arg Lys Gly Lys Lys Ser Asp Ala Asn Ala Ser Tyr Leu Arg Ala Ala 
            20                  25                  30          


Arg Ala Gly His Leu Glu Lys Ala Leu Asp Tyr Ile Lys Asn Gly Val 
        35                  40                  45              


Asp Ile Asn Ile Cys Asn Gln Asn Gly Leu Asn Ala Leu His Leu Ala 
    50                  55                  60                  


Ser Lys Glu Gly His Val Glu Val Val Ser Glu Leu Leu Gln Arg Glu 
65                  70                  75                  80  


Ala Asn Val Asp Ala Ala Xaa Lys Lys Gly Asn Xaa Ala Leu His Ile 
                85                  90                  95      


Ala Ser Leu Ala Gly Gln Ala Glu Val Val Lys Val Leu Val Xaa Asn 
            100                 105                 110         


Gly Ala Asn Val Asn Ala Gln Ser Gln Asn Gly Phe Xaa Pro Leu Tyr 
        115                 120                 125             


Met Ala Ala Gln Glu Asn His Leu Glu Val Val Lys Phe Leu Leu Asp 
    130                 135                 140                 


Asn Gly Ala Ser Gln Ser Leu Ala Xaa Glu Asp Gly Phe Xaa Pro Leu 
145                 150                 155                 160 


Ala Val Ala Leu Gln Gln Gly His Asp Gln Val Val Ser Leu Leu Leu 
                165                 170                 175     


Glu Asn Asp Xaa Lys Gly Lys Val Arg Leu Pro Ala Leu His Ile Ala 
            180                 185                 190         


Ala Arg Lys Asp Asp Xaa Lys Ala Ala Ala Leu Leu Leu Gln Asn Asp 
        195                 200                 205             


Asn Asn Ala Asp Val Glu Ser Lys Ser Gly Phe Xaa Pro Leu His Ile 
    210                 215                 220                 


Ala Ala His Tyr Gly Asn Ile Asn Val Ala Xaa Leu Leu Leu Asn Arg 
225                 230                 235                 240 


Ala Ala Ala Val Asp Phe Xaa Ala Arg Asn Asp Ile Xaa Pro Leu His 
                245                 250                 255     


Val Ala Ser Lys Arg Gly Asn Ala Asn Met Val Lys Leu Leu Leu Asp 
            260                 265                 270         


Arg Gly Ala Lys Ile Asp Ala Lys Xaa Arg Asp Gly Leu Xaa Pro Leu 
        275                 280                 285             


His Cys Gly Ala Arg Ser Gly His Glu Gln Val Val Glu Met Leu Leu 
    290                 295                 300                 


Asp Arg Ala Ala Pro Ile Leu Ser Lys Xaa Lys Asn Gly Leu Ser Pro 
305                 310                 315                 320 


Leu His Met Ala Xaa Gln Gly Asp His Leu Asn Cys Val Gln Leu Leu 
                325                 330                 335     


Leu Gln His Asn Val Pro Val Asp Asp Val Xaa Asn Asp Tyr Leu Xaa 
            340                 345                 350         


Ala Leu His Val Ala Ala His Cys Gly His Tyr Lys Val Ala Lys Val 
        355                 360                 365             


Leu Leu Asp Lys Lys Ala Asn Pro Asn Ala Lys Ala Leu Asn Gly Phe 
    370                 375                 380                 


Xaa Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu 
385                 390                 395                 400 


Leu Leu Leu Lys His Gly Ala Ser Ile Gln Ala Val Xaa Glu Ser Gly 
                405                 410                 415     


Leu Xaa Pro Ile His Val Ala Ala Phe Met Gly His Val Asn Ile Val 
            420                 425                 430         


Ser Gln Leu Met His His Gly Ala Ser Pro Asn Xaa Xaa Asn Val Ser 
        435                 440                 445             


Cys Ser 
    450 


<210> 2321
<211> 1868
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1128)..(1128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1173)..(1173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1218)..(1218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1253)..(1253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1262)..(1262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1268)..(1268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1277)..(1278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1300)..(1300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1342)..(1342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1378)..(1378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1405)..(1405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1421)..(1422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1428)..(1428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1436)..(1436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1465)..(1465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1478)..(1478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1494)..(1494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1531)..(1531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1538)..(1539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1543)..(1543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1556)..(1556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1571)..(1571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1597)..(1597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1599)..(1599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1604)..(1604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1627)..(1627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1653)..(1653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1671)..(1671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1695)..(1695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1710)..(1710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1729)..(1729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1746)..(1746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1749)..(1749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1770)..(1770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1801)..(1801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1809)..(1809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1823)..(1823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1855)..(1855)
<223> Selenocysteine

<400> 2321
Met Ser Glu Glu Pro Lys Glu Lys Asn Ala Lys Pro Ala His Arg Lys 
1               5                   10                  15      


Arg Lys Gly Lys Lys Ser Asp Ala Asn Ala Ser Tyr Leu Arg Ala Ala 
            20                  25                  30          


Arg Ala Gly His Leu Glu Lys Ala Leu Asp Tyr Ile Lys Asn Gly Val 
        35                  40                  45              


Asp Ile Asn Ile Cys Asn Gln Asn Gly Leu Asn Ala Leu His Leu Ala 
    50                  55                  60                  


Ser Lys Glu Gly His Val Glu Val Val Ser Glu Leu Leu Gln Arg Glu 
65                  70                  75                  80  


Ala Asn Val Asp Ala Ala Xaa Lys Lys Gly Asn Xaa Ala Leu His Ile 
                85                  90                  95      


Ala Ser Leu Ala Gly Gln Ala Glu Val Val Lys Val Leu Val Xaa Asn 
            100                 105                 110         


Gly Ala Asn Val Asn Ala Gln Ser Gln Asn Gly Phe Xaa Pro Leu Tyr 
        115                 120                 125             


Met Ala Ala Gln Glu Asn His Leu Glu Val Val Lys Phe Leu Leu Asp 
    130                 135                 140                 


Asn Gly Ala Ser Gln Ser Leu Ala Xaa Glu Asp Gly Phe Xaa Pro Leu 
145                 150                 155                 160 


Ala Val Ala Leu Gln Gln Gly His Asp Gln Val Val Ser Leu Leu Leu 
                165                 170                 175     


Glu Asn Asp Xaa Lys Gly Lys Val Arg Leu Pro Ala Leu His Ile Ala 
            180                 185                 190         


Ala Arg Lys Asp Asp Xaa Lys Ala Ala Ala Leu Leu Leu Gln Asn Asp 
        195                 200                 205             


Asn Asn Ala Asp Val Glu Ser Lys Ser Gly Phe Xaa Pro Leu His Ile 
    210                 215                 220                 


Ala Ala His Tyr Gly Asn Ile Asn Val Ala Xaa Leu Leu Leu Asn Arg 
225                 230                 235                 240 


Ala Ala Ala Val Asp Phe Xaa Ala Arg Asn Asp Ile Xaa Pro Leu His 
                245                 250                 255     


Val Ala Ser Lys Arg Gly Asn Ala Asn Met Val Lys Leu Leu Leu Asp 
            260                 265                 270         


Arg Gly Ala Lys Ile Asp Ala Lys Xaa Arg Asp Gly Leu Xaa Pro Leu 
        275                 280                 285             


His Cys Gly Ala Arg Ser Gly His Glu Gln Val Val Glu Met Leu Leu 
    290                 295                 300                 


Asp Arg Ala Ala Pro Ile Leu Ser Lys Xaa Lys Asn Gly Leu Ser Pro 
305                 310                 315                 320 


Leu His Met Ala Xaa Gln Gly Asp His Leu Asn Cys Val Gln Leu Leu 
                325                 330                 335     


Leu Gln His Asn Val Pro Val Asp Asp Val Xaa Asn Asp Tyr Leu Xaa 
            340                 345                 350         


Ala Leu His Val Ala Ala His Cys Gly His Tyr Lys Val Ala Lys Val 
        355                 360                 365             


Leu Leu Asp Lys Lys Ala Asn Pro Asn Ala Lys Ala Leu Asn Gly Phe 
    370                 375                 380                 


Xaa Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu 
385                 390                 395                 400 


Leu Leu Leu Lys His Gly Ala Ser Ile Gln Ala Val Xaa Glu Ser Gly 
                405                 410                 415     


Leu Xaa Pro Ile His Val Ala Ala Phe Met Gly His Val Asn Ile Val 
            420                 425                 430         


Ser Gln Leu Met His His Gly Ala Ser Pro Asn Xaa Xaa Asn Val Arg 
        435                 440                 445             


Gly Glu Xaa Ala Leu His Met Ala Ala Arg Ser Gly Gln Ala Glu Val 
    450                 455                 460                 


Val Arg Tyr Leu Val Gln Asp Gly Ala Gln Val Glu Ala Lys Ala Lys 
465                 470                 475                 480 


Asp Asp Gln Xaa Pro Leu His Ile Ser Ala Arg Leu Gly Lys Ala Asp 
                485                 490                 495     


Ile Val Gln Gln Leu Leu Gln Gln Gly Ala Ser Pro Asn Ala Ala Xaa 
            500                 505                 510         


Xaa Ser Gly Tyr Xaa Pro Leu His Leu Ser Ala Arg Glu Gly His Glu 
        515                 520                 525             


Asp Val Ala Ala Phe Leu Leu Asp His Gly Ala Ser Leu Ser Ile Xaa 
    530                 535                 540                 


Xaa Lys Lys Gly Phe Xaa Pro Leu His Val Ala Ala Lys Tyr Gly Lys 
545                 550                 555                 560 


Leu Glu Val Ala Asn Leu Leu Leu Gln Lys Ser Ala Ser Pro Asp Ala 
                565                 570                 575     


Ala Gly Lys Ser Gly Leu Xaa Pro Leu His Val Ala Ala His Tyr Asp 
            580                 585                 590         


Asn Gln Lys Val Ala Leu Leu Leu Leu Asp Gln Gly Ala Ser Pro His 
        595                 600                 605             


Ala Ala Ala Lys Asn Gly Tyr Xaa Pro Leu His Ile Ala Ala Lys Lys 
    610                 615                 620                 


Asn Gln Met Asp Ile Ala Xaa Xaa Leu Leu Glu Tyr Gly Ala Asp Ala 
625                 630                 635                 640 


Asn Ala Val Xaa Arg Gln Gly Ile Ala Ser Val His Leu Ala Ala Gln 
                645                 650                 655     


Glu Gly His Val Asp Met Val Ser Leu Leu Leu Gly Arg Asn Ala Asn 
            660                 665                 670         


Val Asn Leu Ser Asn Lys Ser Gly Leu Xaa Pro Leu His Leu Ala Ala 
        675                 680                 685             


Gln Glu Asp Arg Val Asn Val Ala Glu Val Leu Val Asn Gln Gly Ala 
    690                 695                 700                 


His Val Asp Ala Gln Xaa Lys Met Gly Tyr Xaa Pro Leu His Val Gly 
705                 710                 715                 720 


Cys His Tyr Gly Asn Ile Lys Ile Val Asn Phe Leu Leu Gln His Ser 
                725                 730                 735     


Ala Lys Val Asn Ala Lys Xaa Lys Asn Gly Tyr Xaa Pro Leu His Gln 
            740                 745                 750         


Ala Ala Gln Gln Gly His Xaa His Ile Ile Asn Val Leu Leu Gln Asn 
        755                 760                 765             


Asn Ala Ser Pro Asn Glu Leu Xaa Val Asn Gly Asn Xaa Ala Leu Gly 
    770                 775                 780                 


Ile Ala Arg Arg Leu Gly Tyr Ile Ser Val Val Asp Xaa Leu Lys Ile 
785                 790                 795                 800 


Val Xaa Glu Glu Xaa Met Xaa Xaa Xaa Xaa Val Xaa Glu Lys His Lys 
                805                 810                 815     


Met Asn Val Pro Glu Xaa Met Asn Glu Val Leu Asp Met Ser Asp Asp 
            820                 825                 830         


Glu Val Arg Lys Ala Asn Ala Pro Glu Met Leu Ser Asp Gly Glu Tyr 
        835                 840                 845             


Ile Ser Asp Val Glu Glu Gly Asn Arg Cys Xaa Trp Tyr Lys Ile Pro 
    850                 855                 860                 


Lys Val Gln Glu Phe Xaa Val Lys Ser Glu Asp Ala Met Xaa Gly Asp 
865                 870                 875                 880 


Xaa Asp Lys Tyr Leu Gly Pro Gln Asp Leu Lys Glu Leu Gly Asp Asp 
                885                 890                 895     


Ser Leu Pro Ala Glu Gly Tyr Met Gly Phe Ser Leu Gly Ala Arg Ser 
            900                 905                 910         


Ala Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser Tyr Xaa Leu Asn Arg 
        915                 920                 925             


Ser Ser Tyr Ala Arg Asp Ser Met Met Ile Glu Glu Leu Leu Val Pro 
    930                 935                 940                 


Ser Lys Glu Gln His Leu Xaa Phe Xaa Arg Glu Phe Asp Ser Asp Ser 
945                 950                 955                 960 


Leu Arg His Tyr Ser Trp Ala Ala Asp Xaa Leu Asp Asn Val Asn Leu 
                965                 970                 975     


Val Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp 
            980                 985                 990         


Ala Arg Gly Gly Ser Met Arg Gly  Ser Arg His His Gly  Met Arg Ile 
        995                 1000                 1005             


Ile Ile  Pro Pro Arg Lys Cys  Xaa Ala Pro Xaa Arg  Ile Xaa Cys 
    1010                 1015                 1020             


Arg Leu  Val Lys Arg His Lys  Leu Ala Asn Pro Pro  Pro Met Val 
    1025                 1030                 1035             


Glu Gly  Glu Gly Leu Ala Ser  Arg Leu Val Glu Met  Gly Pro Ala 
    1040                 1045                 1050             


Gly Ala  Gln Phe Leu Gly Pro  Val Ile Val Glu Ile  Pro His Phe 
    1055                 1060                 1065             


Gly Ser  Met Arg Gly Lys Glu  Arg Glu Leu Ile Val  Leu Arg Ser 
    1070                 1075                 1080             


Glu Asn  Gly Glu Xaa Trp Lys  Glu His Gln Phe Asp  Ser Lys Asn 
    1085                 1090                 1095             


Glu Asp  Leu Xaa Glu Leu Leu  Asn Gly Met Asp Glu  Glu Leu Asp 
    1100                 1105                 1110             


Ser Pro  Glu Glu Leu Gly Lys  Lys Arg Ile Cys Arg  Ile Ile Xaa 
    1115                 1120                 1125             


Lys Asp  Phe Pro Gln Tyr Phe  Ala Val Val Ser Arg  Ile Lys Gln 
    1130                 1135                 1140             


Glu Ser  Asn Gln Ile Gly Pro  Glu Gly Gly Ile Leu  Ser Ser Xaa 
    1145                 1150                 1155             


Xaa Val  Pro Leu Val Gln Ala  Ser Phe Pro Glu Gly  Ala Leu Xaa 
    1160                 1165                 1170             


Lys Arg  Ile Arg Val Gly Leu  Gln Ala Gln Pro Val  Pro Asp Glu 
    1175                 1180                 1185             


Ile Val  Lys Lys Ile Leu Gly  Asn Lys Ala Xaa Phe  Ser Pro Ile 
    1190                 1195                 1200             


Val Xaa  Val Glu Pro Arg Arg  Arg Lys Phe His Lys  Pro Ile Xaa 
    1205                 1210                 1215             


Met Xaa  Ile Pro Val Pro Pro  Pro Ser Gly Glu Gly  Val Ser Asn 
    1220                 1225                 1230             


Gly Tyr  Lys Gly Asp Xaa Xaa  Pro Asn Leu Arg Leu  Leu Cys Ser 
    1235                 1240                 1245             


Ile Xaa  Gly Gly Xaa Ser Pro  Ala Gln Trp Glu Asp  Ile Xaa Gly 
    1250                 1255                 1260             


Xaa Xaa  Pro Leu Xaa Phe Ile  Lys Asp Cys Val Ser  Phe Xaa Xaa 
    1265                 1270                 1275             


Asn Val  Ser Ala Arg Phe Trp  Leu Ala Asp Cys His  Gln Val Leu 
    1280                 1285                 1290             


Glu Xaa  Val Gly Leu Ala Xaa  Gln Leu Tyr Arg Glu  Leu Ile Cys 
    1295                 1300                 1305             


Val Pro  Tyr Met Ala Lys Phe  Val Val Phe Ala Lys  Met Asn Asp 
    1310                 1315                 1320             


Pro Val  Glu Ser Ser Leu Arg  Cys Phe Cys Met Xaa  Asp Asp Lys 
    1325                 1330                 1335             


Val Asp  Lys Xaa Leu Glu Gln  Gln Glu Asn Phe Glu  Glu Val Ala 
    1340                 1345                 1350             


Arg Ser  Lys Asp Ile Glu Val  Leu Glu Gly Lys Pro  Ile Tyr Val 
    1355                 1360                 1365             


Asp Cys  Tyr Gly Asn Leu Ala  Pro Leu Xaa Lys Gly  Gly Gln Gln 
    1370                 1375                 1380             


Leu Val  Phe Asn Phe Tyr Ser  Phe Lys Glu Asn Arg  Leu Pro Phe 
    1385                 1390                 1395             


Ser Ile  Lys Ile Arg Asp Xaa  Ser Gln Glu Pro Cys  Gly Arg Leu 
    1400                 1405                 1410             


Ser Phe  Leu Lys Glu Pro Lys  Xaa Xaa Lys Gly Leu  Pro Gln Xaa 
    1415                 1420                 1425             


Ala Val  Cys Asn Leu Asn Ile  Xaa Leu Pro Ala His  Lys Lys Ile 
    1430                 1435                 1440             


Glu Lys  Xaa Asp Arg Arg Gln  Ser Phe Ala Ser Leu  Ala Leu Arg 
    1445                 1450                 1455             


Lys Arg  Tyr Ser Tyr Leu Xaa  Glu Pro Gly Met Ser  Pro Gln Ser 
    1460                 1465                 1470             


Pro Cys  Glu Arg Xaa Asp Ile  Arg Met Ala Ile Val  Ala Asp His 
    1475                 1480                 1485             


Leu Gly  Leu Ser Trp Xaa Glu  Leu Ala Arg Glu Leu  Asn Phe Ser 
    1490                 1495                 1500             


Val Asp  Glu Ile Asn Gln Ile  Arg Val Glu Asn Pro  Asn Ser Leu 
    1505                 1510                 1515             


Ile Ser  Gln Ser Phe Met Leu  Leu Lys Lys Trp Val  Xaa Arg Asp 
    1520                 1525                 1530             


Gly Lys  Asn Ala Xaa Xaa Asp  Ala Leu Xaa Ser Val  Leu Xaa Lys 
    1535                 1540                 1545             


Ile Asn  Arg Ile Asp Ile Val  Xaa Leu Leu Glu Gly  Pro Ile Phe 
    1550                 1555                 1560             


Asp Tyr  Gly Asn Ile Ser Gly  Xaa Arg Ser Phe Ala  Asp Glu Asn 
    1565                 1570                 1575             


Asn Val  Phe His Asp Pro Val  Asp Gly Tyr Pro Ser  Leu Gln Val 
    1580                 1585                 1590             


Glu Leu  Glu Xaa Pro Xaa Gly  Leu His Tyr Xaa Pro  Pro Xaa Pro 
    1595                 1600                 1605             


Phe Gln  Gln Asp Asp Tyr Phe  Ser Asp Ile Ser Ser  Ile Glu Ser 
    1610                 1615                 1620             


Pro Leu  Arg Xaa Pro Ser Arg  Leu Ser Asp Gly Leu  Val Pro Ser 
    1625                 1630                 1635             


Gln Gly  Asn Ile Glu His Ser  Ala Asp Gly Pro Pro  Val Val Xaa 
    1640                 1645                 1650             


Ala Glu  Asp Ala Ser Leu Glu  Asp Ser Lys Leu Glu  Asp Ser Val 
    1655                 1660                 1665             


Pro Leu  Xaa Glu Met Pro Glu  Ala Val Asp Val Asp  Glu Ser Gln 
    1670                 1675                 1680             


Leu Glu  Asn Val Cys Leu Ser  Trp Gln Asn Glu Xaa  Ser Ser Gly 
    1685                 1690                 1695             


Asn Leu  Glu Ser Cys Ala Gln  Ala Arg Arg Val Xaa  Gly Gly Leu 
    1700                 1705                 1710             


Leu Asp  Arg Leu Asp Asp Ser  Pro Asp Gln Cys Arg  Asp Ser Ile 
    1715                 1720                 1725             


Xaa Ser  Tyr Leu Lys Gly Glu  Ala Gly Lys Phe Glu  Ala Asn Gly 
    1730                 1735                 1740             


Ser His  Xaa Glu Ile Xaa Pro  Glu Ala Lys Xaa Lys  Ser Tyr Phe 
    1745                 1750                 1755             


Pro Glu  Ser Gln Asn Asp Val  Gly Lys Gln Ser Xaa  Lys Glu Xaa 
    1760                 1765                 1770             


Leu Lys  Pro Lys Ile His Gly  Ser Gly His Val Glu  Glu Pro Ala 
    1775                 1780                 1785             


Ser Pro  Leu Ala Ala Tyr Gln  Lys Ser Leu Glu Glu  Xaa Ser Lys 
    1790                 1795                 1800             


Leu Ile  Ile Glu Glu Xaa Lys  Pro Cys Val Pro Val  Ser Met Lys 
    1805                 1810                 1815             


Lys Met  Ser Arg Xaa Ser Pro  Ala Asp Gly Lys Pro  Arg Leu Ser 
    1820                 1825                 1830             


Leu His  Glu Glu Glu Gly Ser  Ser Gly Ser Glu Gln  Lys Gln Gly 
    1835                 1840                 1845             


Glu Gly  Phe Lys Val Lys Xaa  Lys Lys Glu Ile Arg  His Val Glu 
    1850                 1855                 1860             


Lys Lys  Ser His Ser 
    1865             


<210> 2322
<211> 63
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<400> 2322
Met Xaa Gly Asp Xaa Asp Lys Tyr Leu Gly Pro Gln Asp Leu Lys Glu 
1               5                   10                  15      


Leu Gly Asp Asp Ser Leu Pro Ala Glu Gly Tyr Met Gly Phe Ser Leu 
            20                  25                  30          


Gly Ala Arg Ser Ala Ser His Ala Ala Ser Xaa Val Ala Lys Glu Leu 
        35                  40                  45              


Xaa Asp Lys Xaa Gly Arg Xaa Asn Leu Ser His Ile Phe Gln Asn 
    50                  55                  60              


<210> 2323
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<400> 2323
Met Xaa Gly Asp Xaa Asp Lys Tyr Leu Gly Pro Gln Asp Leu Lys Glu 
1               5                   10                  15      


Leu Gly Asp Asp Ser Leu Pro Ala Glu Gly Tyr Met Gly Phe Ser Leu 
            20                  25                  30          


Gly Ala Arg Ser Ala Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser Tyr 
        35                  40                  45              


Xaa Leu Asn Arg Ser Ser Tyr Ala Arg Asp Ser Met Met Ile Glu Glu 
    50                  55                  60                  


Leu Leu Val Pro Ser Lys Glu Gln 
65                  70          


<210> 2324
<211> 159
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<400> 2324
Met Xaa Gly Asp Xaa Asp Lys Tyr Leu Gly Pro Gln Asp Leu Lys Glu 
1               5                   10                  15      


Leu Gly Asp Asp Ser Leu Pro Ala Glu Gly Tyr Met Gly Phe Ser Leu 
            20                  25                  30          


Gly Ala Arg Ser Ala Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser Tyr 
        35                  40                  45              


Xaa Leu Asn Arg Ser Ser Tyr Ala Arg Asp Ser Met Met Ile Glu Glu 
    50                  55                  60                  


Leu Leu Val Pro Ser Lys Glu Gln His Leu Xaa Phe Xaa Arg Glu Phe 
65                  70                  75                  80  


Asp Ser Asp Ser Leu Arg His Tyr Ser Trp Ala Ala Asp Xaa Leu Asp 
                85                  90                  95      


Asn Val Asn Leu Val Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser 
            100                 105                 110         


Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg Gly Ser Arg His His 
        115                 120                 125             


Gly Met Arg Ile Ile Ile Pro Pro Arg Lys Cys Xaa Ala Pro Xaa Arg 
    130                 135                 140                 


Ile Xaa Cys Arg Leu Val Lys Arg His Lys Leu Ala Asn Pro Pro 
145                 150                 155                 


<210> 2325
<211> 195
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<400> 2325
Met Xaa Gly Asp Xaa Asp Lys Tyr Leu Gly Pro Gln Asp Leu Lys Glu 
1               5                   10                  15      


Leu Gly Asp Asp Ser Leu Pro Ala Glu Gly Tyr Met Gly Phe Ser Leu 
            20                  25                  30          


Gly Ala Arg Ser Ala Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser Tyr 
        35                  40                  45              


Xaa Leu Asn Arg Ser Ser Tyr Ala Arg Asp Ser Met Met Ile Glu Glu 
    50                  55                  60                  


Leu Leu Val Pro Ser Lys Glu Gln His Leu Xaa Phe Xaa Arg Glu Phe 
65                  70                  75                  80  


Asp Ser Asp Ser Leu Arg His Tyr Ser Trp Ala Ala Asp Xaa Leu Asp 
                85                  90                  95      


Asn Val Asn Leu Val Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser 
            100                 105                 110         


Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg Gly Ser Arg His His 
        115                 120                 125             


Gly Met Arg Ile Ile Ile Pro Pro Arg Lys Cys Xaa Ala Pro Xaa Arg 
    130                 135                 140                 


Ile Xaa Cys Arg Leu Val Lys Arg His Lys Leu Ala Asn Pro Pro Pro 
145                 150                 155                 160 


Met Val Glu Gly Glu Gly Leu Ala Ser Arg Leu Val Glu Met Gly Pro 
                165                 170                 175     


Ala Gly Ala Gln Phe Leu Gly Pro Val Ile Val Glu Ile Pro His Phe 
            180                 185                 190         


Gly Ser Met 
        195 


<210> 2326
<211> 459
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<400> 2326
Pro Lys Xaa Xaa Lys Gly Leu Pro Gln Xaa Ala Val Cys Asn Leu Asn 
1               5                   10                  15      


Ile Xaa Leu Pro Ala His Lys Lys Glu Xaa Glu Ser Asp Gln Asp Asp 
            20                  25                  30          


Glu Ile Glu Lys Xaa Asp Arg Arg Gln Ser Phe Ala Ser Leu Ala Leu 
        35                  40                  45              


Arg Lys Arg Tyr Ser Tyr Leu Xaa Glu Pro Gly Met Ser Pro Gln Ser 
    50                  55                  60                  


Pro Cys Glu Arg Xaa Asp Ile Arg Met Ala Ile Val Ala Asp His Leu 
65                  70                  75                  80  


Gly Leu Ser Trp Xaa Glu Leu Ala Arg Glu Leu Asn Phe Ser Val Asp 
                85                  90                  95      


Glu Ile Asn Gln Ile Arg Val Glu Asn Pro Asn Ser Leu Ile Ser Gln 
            100                 105                 110         


Ser Phe Met Leu Leu Lys Lys Trp Val Xaa Arg Asp Gly Lys Asn Ala 
        115                 120                 125             


Xaa Xaa Asp Ala Leu Xaa Ser Val Leu Xaa Lys Ile Asn Arg Ile Asp 
    130                 135                 140                 


Ile Val Xaa Leu Leu Glu Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser 
145                 150                 155                 160 


Gly Xaa Arg Ser Phe Ala Asp Glu Asn Asn Val Phe His Asp Pro Val 
                165                 170                 175     


Asp Gly Tyr Pro Ser Leu Gln Val Glu Leu Glu Xaa Pro Xaa Gly Leu 
            180                 185                 190         


His Tyr Xaa Pro Pro Xaa Pro Phe Gln Gln Asp Asp Tyr Phe Ser Asp 
        195                 200                 205             


Ile Ser Ser Ile Glu Ser Pro Leu Arg Xaa Pro Ser Arg Leu Ser Asp 
    210                 215                 220                 


Gly Leu Val Pro Ser Gln Gly Asn Ile Glu His Ser Ala Asp Gly Pro 
225                 230                 235                 240 


Pro Val Val Xaa Ala Glu Asp Ala Ser Leu Glu Asp Ser Lys Leu Glu 
                245                 250                 255     


Asp Ser Val Pro Leu Xaa Glu Met Pro Glu Ala Val Asp Val Asp Glu 
            260                 265                 270         


Ser Gln Leu Glu Asn Val Cys Leu Ser Trp Gln Asn Glu Xaa Ser Ser 
        275                 280                 285             


Gly Asn Leu Glu Ser Cys Ala Gln Ala Arg Arg Val Xaa Gly Gly Leu 
    290                 295                 300                 


Leu Asp Arg Leu Asp Asp Ser Pro Asp Gln Cys Arg Asp Ser Ile Xaa 
305                 310                 315                 320 


Ser Tyr Leu Lys Gly Glu Ala Gly Lys Phe Glu Ala Asn Gly Ser His 
                325                 330                 335     


Xaa Glu Ile Xaa Pro Glu Ala Lys Xaa Lys Ser Tyr Phe Pro Glu Ser 
            340                 345                 350         


Gln Asn Asp Val Gly Lys Gln Ser Xaa Lys Glu Xaa Leu Lys Pro Lys 
        355                 360                 365             


Ile His Gly Ser Gly His Val Glu Glu Pro Ala Ser Pro Leu Ala Ala 
    370                 375                 380                 


Tyr Gln Lys Ser Leu Glu Glu Xaa Ser Lys Leu Ile Ile Glu Glu Xaa 
385                 390                 395                 400 


Lys Pro Cys Val Pro Val Ser Met Lys Lys Met Ser Arg Xaa Ser Pro 
                405                 410                 415     


Ala Asp Gly Lys Pro Arg Leu Ser Leu His Glu Glu Glu Gly Ser Ser 
            420                 425                 430         


Gly Ser Glu Gln Lys Gln Gly Glu Gly Phe Lys Val Lys Xaa Lys Lys 
        435                 440                 445             


Glu Ile Arg His Val Glu Lys Lys Ser His Ser 
    450                 455                 


<210> 2327
<211> 166
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<400> 2327
Ser Pro Asp Gln Cys Arg Asp Ser Ile Xaa Ser Tyr Leu Lys Gly Glu 
1               5                   10                  15      


Ala Gly Lys Phe Glu Ala Asn Gly Ser His Xaa Glu Ile Xaa Pro Glu 
            20                  25                  30          


Ala Lys Xaa Lys Ser Tyr Phe Pro Glu Ser Gln Asn Asp Val Gly Lys 
        35                  40                  45              


Gln Ser Xaa Lys Glu Xaa Leu Lys Pro Lys Ile His Gly Ser Gly His 
    50                  55                  60                  


Val Glu Glu Pro Ala Ser Pro Leu Ala Ala Tyr Gln Lys Ser Leu Glu 
65                  70                  75                  80  


Glu Xaa Ser Lys Leu Ile Ile Glu Glu Xaa Lys Pro Cys Val Pro Val 
                85                  90                  95      


Ser Met Lys Lys Met Ser Arg Xaa Ser Pro Ala Asp Gly Lys Pro Arg 
            100                 105                 110         


Leu Ser Leu His Glu Glu Glu Gly Ser Ser Gly Ser Glu Gln Lys Val 
        115                 120                 125             


Lys Ser Pro Gly Ala Ala Pro Xaa Arg Met Xaa Ala Cys Cys Tyr Lys 
    130                 135                 140                 


Gln Gly Glu Gly Phe Lys Val Lys Xaa Lys Lys Glu Ile Arg His Val 
145                 150                 155                 160 


Glu Lys Lys Ser His Ser 
                165     


<210> 2328
<211> 114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<400> 2328
Xaa Val Xaa Glu Lys His Lys Met Asn Val Pro Glu Xaa Met Asn Glu 
1               5                   10                  15      


Val Leu Asp Met Ser Asp Asp Glu Val Arg Lys Ala Asn Ala Pro Glu 
            20                  25                  30          


Met Leu Ser Asp Gly Glu Tyr Ile Ser Asp Val Glu Glu Gly Asn Arg 
        35                  40                  45              


Cys Xaa Trp Tyr Lys Ile Pro Lys Val Gln Glu Phe Xaa Val Lys Ser 
    50                  55                  60                  


Glu Asp Ala Met Xaa Gly Asp Xaa Asp Lys Tyr Leu Gly Pro Gln Asp 
65                  70                  75                  80  


Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ala Glu Gly Tyr Met Gly 
                85                  90                  95      


Phe Ser Leu Gly Ala Arg Ser Ala Arg Tyr Phe Val Val Ala Val Phe 
            100                 105                 110         


His Ser 
        


<210> 2329
<211> 868
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<400> 2329
Xaa Asp Leu Pro Asp Glu Ser Val Ser Val Gln Lys Asp Phe Met Val 
1               5                   10                  15      


Leu Lys Xaa Lys Asp Glu His Ala Gln Ser Asn Glu Ile Val Val Asn 
            20                  25                  30          


Asp Ser Gly Ser Asp Asn Val Lys Lys Gln Arg Xaa Glu Met Ser Ser 
        35                  40                  45              


Lys Ala Met Pro Asp Ser Phe Ser Glu Gln Gln Ala Lys Asp Leu Ala 
    50                  55                  60                  


Cys His Ile Xaa Ser Asp Leu Ala Xaa Arg Gly Pro Trp Asp Lys Lys 
65                  70                  75                  80  


Val Phe Arg Xaa Trp Glu Ser Ser Gly Ala Xaa Asn Asn Lys Ser Gln 
                85                  90                  95      


Lys Glu Lys Leu Ser His Val Leu Val His Asp Val Arg Glu Asn His 
            100                 105                 110         


Ile Gly His Pro Glu Ser Lys Ser Val Asp Gln Lys Asn Glu Phe Met 
        115                 120                 125             


Ser Val Xaa Glu Arg Glu Arg Lys Leu Leu Xaa Asn Gly Ser Leu Ser 
    130                 135                 140                 


Glu Ile Lys Glu Met Xaa Val Lys Ser Pro Ser Lys Lys Val Leu Tyr 
145                 150                 155                 160 


Arg Glu Tyr Val Val Lys Glu Gly Asp His Pro Gly Gly Leu Leu Asp 
                165                 170                 175     


Gln Pro Ser Arg Arg Ser Glu Ser Ser Ala Val Ser His Ile Pro Val 
            180                 185                 190         


Arg Val Ala Asp Glu Arg Arg Met Leu Ser Ser Asn Ile Pro Asp Gly 
        195                 200                 205             


Phe Cys Glu Gln Ser Ala Phe Pro Lys His Glu Leu Ser Gln Lys Leu 
    210                 215                 220                 


Ser Gln Ser Ser Met Ser Lys Glu Xaa Val Glu Xaa Gln His Phe Asn 
225                 230                 235                 240 


Ser Ile Glu Asp Glu Lys Val Xaa Tyr Ser Glu Ile Ser Lys Val Ser 
                245                 250                 255     


Lys His Gln Ser Tyr Val Gly Leu Cys Pro Pro Leu Glu Glu Xaa Glu 
            260                 265                 270         


Xaa Ser Pro Xaa Lys Ser Pro Asp Ser Leu Glu Phe Ser Pro Gly Lys 
        275                 280                 285             


Glu Ser Pro Ser Ser Asp Val Phe Asp His Ser Pro Ile Asp Gly Leu 
    290                 295                 300                 


Glu Lys Leu Ala Pro Leu Ala Gln Xaa Glu Gly Gly Lys Glu Ile Lys 
305                 310                 315                 320 


Xaa Leu Pro Val Tyr Val Ser Phe Val Gln Val Gly Lys Gln Tyr Glu 
                325                 330                 335     


Lys Glu Ile Gln Gln Gly Gly Val Lys Lys Ile Ile Ser Gln Glu Cys 
            340                 345                 350         


Lys Xaa Val Gln Glu Xaa Arg Gly Xaa Phe Tyr Xaa Xaa Arg Gln Gln 
        355                 360                 365             


Lys Gln Pro Pro Ser Pro Gln Gly Ser Pro Glu Asp Asp Xaa Leu Glu 
    370                 375                 380                 


Gln Val Ser Phe Leu Asp Ser Ser Gly Lys Ser Pro Leu Xaa Pro Glu 
385                 390                 395                 400 


Xaa Pro Ser Ser Glu Glu Val Ser Tyr Glu Phe Xaa Ser Lys Xaa Pro 
                405                 410                 415     


Asp Ser Leu Ile Ala Tyr Ile Pro Gly Lys Pro Ser Pro Ile Pro Glu 
            420                 425                 430         


Val Ser Glu Glu Ser Glu Glu Glu Glu Gln Ala Lys Ser Xaa Ser Leu 
        435                 440                 445             


Lys Gln Xaa Xaa Val Glu Glu Xaa Ala Val Glu Arg Glu Met Pro Asn 
    450                 455                 460                 


Asp Val Ser Lys Asp Ser Asn Gln Arg Pro Lys Asn Asn Arg Val Ala 
465                 470                 475                 480 


Tyr Ile Glu Phe Pro Pro Pro Pro Pro Leu Asp Ala Asp Gln Ile Glu 
                485                 490                 495     


Ser Asp Lys Lys His His Tyr Leu Pro Glu Lys Glu Val Asp Met Ile 
            500                 505                 510         


Glu Val Asn Leu Gln Asp Glu His Asp Lys Tyr Gln Leu Ala Glu Pro 
        515                 520                 525             


Val Ile Arg Val Gln Pro Pro Ser Pro Val Pro Pro Gly Ala Asp Val 
    530                 535                 540                 


Ser Asp Ser Ser Asp Asp Glu Ser Ile Tyr Gln Pro Val Pro Val Lys 
545                 550                 555                 560 


Lys Tyr Xaa Phe Lys Leu Lys Glu Val Asp Asp Glu Gln Lys Glu Lys 
                565                 570                 575     


Pro Lys Ala Ser Ala Glu Lys Ala Ser Asn Gln Lys Glu Leu Glu Ser 
            580                 585                 590         


Asn Gly Ser Gly Lys Asp Asn Glu Phe Gly Leu Gly Leu Asp Ser Pro 
        595                 600                 605             


Gln Asn Glu Ile Ala Gln Asn Gly Asn Asn Asp Gln Ser Ile Xaa Glu 
    610                 615                 620                 


Cys Ser Ile Ala Xaa Xaa Ala Glu Phe Ser His Asp Xaa Asp Ala Xaa 
625                 630                 635                 640 


Glu Ile Asp Ser Leu Asp Gly Tyr Asp Leu Gln Asp Glu Asp Asp Gly 
                645                 650                 655     


Leu Xaa Glu Ser Asp Ser Lys Leu Pro Ile Gln Ala Met Glu Ile Lys 
            660                 665                 670         


Lys Asp Ile Trp Asn Xaa Glu Gly Ile Leu Lys Pro Ala Asp Arg Ser 
        675                 680                 685             


Phe Ser Gln Ser Lys Leu Glu Val Ile Glu Glu Glu Gly Lys Val Gly 
    690                 695                 700                 


Pro Asp Glu Asp Lys Pro Pro Ser Lys Ser Ser Ser Ser Glu Lys Xaa 
705                 710                 715                 720 


Pro Asp Lys Xaa Asp Gln Lys Ser Gly Ala Gln Phe Phe Xaa Leu Glu 
                725                 730                 735     


Gly Arg His Pro Asp Arg Ser Val Phe Pro Asp Xaa Tyr Phe Ser Tyr 
            740                 745                 750         


Lys Val Asp Glu Glu Phe Ala Xaa Pro Phe Lys Xaa Val Ala Xaa Lys 
        755                 760                 765             


Gly Leu Asp Phe Asp Pro Trp Ser Asn Asn Arg Gly Asp Asp Glu Val 
    770                 775                 780                 


Phe Asp Ser Lys Ser Arg Glu Asp Glu Xaa Lys Pro Phe Gly Leu Ala 
785                 790                 795                 800 


Val Glu Asp Arg Ser Pro Ala Xaa Xaa Pro Asp Xaa Xaa Pro Ala Arg 
                805                 810                 815     


Xaa Pro Xaa Asp Glu Ser Xaa Pro Xaa Ser Glu Pro Asn Pro Phe Pro 
            820                 825                 830         


Phe His Glu Gly Lys Met Phe Glu Met Xaa Arg Ser Gly Ala Ile Asp 
        835                 840                 845             


Met Ser Lys Arg Asp Phe Val Glu Glu Arg Leu Gln Phe Phe Gln Ile 
    850                 855                 860                 


Val Val Arg Pro 
865             


<210> 2330
<211> 202
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 2330
Xaa Glu Asp Ala Met Xaa Gly Asp Xaa Asp Lys Tyr Leu Gly Pro Gln 
1               5                   10                  15      


Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ala Glu Gly Tyr Met 
            20                  25                  30          


Gly Phe Ser Leu Gly Ala Arg Ser Ala Ser Pro Lys Ile Ser Leu Arg 
        35                  40                  45              


Ser Phe Ser Ser Asp Arg Ser Tyr Xaa Leu Asn Arg Ser Ser Tyr Ala 
    50                  55                  60                  


Arg Asp Ser Met Met Ile Glu Glu Leu Leu Val Pro Ser Lys Glu Gln 
65                  70                  75                  80  


His Leu Xaa Phe Xaa Arg Glu Phe Asp Ser Asp Ser Leu Arg His Tyr 
                85                  90                  95      


Ser Trp Ala Ala Asp Xaa Leu Asp Asn Val Asn Leu Val Ser Ser Pro 
            100                 105                 110         


Ile His Ser Gly Tyr Ser Ser Pro Leu Pro Gln Tyr Asp Ser Arg Phe 
        115                 120                 125             


Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg Gly Ser 
    130                 135                 140                 


Arg His His Gly Met Arg Ile Ile Ile Pro Pro Arg Lys Cys Xaa Ala 
145                 150                 155                 160 


Pro Xaa Arg Ile Xaa Cys Arg Leu Val Lys Arg His Lys Leu Ala Asn 
                165                 170                 175     


Pro Pro Pro Met Val Glu Gly Glu Gly Leu Ala Ser Arg Leu Val Glu 
            180                 185                 190         


Met Gly Pro Ala Gly Ala Gln Phe Leu Gly 
        195                 200         


<210> 2331
<211> 1643
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1058)..(1058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1176)..(1176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1197)..(1197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1255)..(1255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1281)..(1281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1322)..(1322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1356)..(1356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1372)..(1372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1409)..(1409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1416)..(1417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1421)..(1421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1425)..(1425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1449)..(1449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1470)..(1470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1485)..(1485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1504)..(1504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1521)..(1521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1524)..(1524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1529)..(1529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1548)..(1548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1576)..(1576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1584)..(1584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1598)..(1598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1630)..(1630)
<223> Selenocysteine

<400> 2331
Xaa Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg 
1               5                   10                  15      


Gly Ser Arg His His Gly Met Arg Ile Ile Ile Pro Pro Arg Lys Cys 
            20                  25                  30          


Xaa Ala Pro Xaa Arg Ile Xaa Cys Arg Leu Val Lys Arg His Lys Leu 
        35                  40                  45              


Ala Asn Pro Pro Pro Met Val Glu Gly Glu Gly Leu Ala Ser Arg Leu 
    50                  55                  60                  


Val Glu Met Gly Pro Ala Gly Ala Gln Phe Leu Gly Pro Val Ile Val 
65                  70                  75                  80  


Glu Ile Pro His Phe Gly Ser Met Arg Gly Lys Glu Arg Glu Leu Ile 
                85                  90                  95      


Val Leu Arg Ser Glu Asn Gly Glu Xaa Trp Lys Glu His Gln Phe Asp 
            100                 105                 110         


Ser Lys Asn Glu Asp Leu Xaa Glu Leu Leu Asn Gly Met Asp Glu Glu 
        115                 120                 125             


Leu Asp Ser Pro Glu Glu Leu Gly Lys Lys Arg Ile Cys Arg Ile Ile 
    130                 135                 140                 


Xaa Lys Asp Phe Pro Gln Tyr Phe Ala Val Val Ser Arg Ile Lys Gln 
145                 150                 155                 160 


Glu Ser Asn Gln Ile Gly Pro Glu Gly Gly Ile Leu Ser Ser Xaa Xaa 
                165                 170                 175     


Val Pro Leu Val Gln Ala Ser Phe Pro Glu Gly Ala Leu Xaa Lys Arg 
            180                 185                 190         


Ile Arg Val Gly Leu Gln Ala Gln Pro Val Pro Asp Glu Ile Val Lys 
        195                 200                 205             


Lys Ile Leu Gly Asn Lys Ala Xaa Phe Ser Pro Ile Val Xaa Val Glu 
    210                 215                 220                 


Pro Arg Arg Arg Lys Phe His Lys Pro Ile Xaa Met Xaa Ile Pro Val 
225                 230                 235                 240 


Pro Pro Pro Ser Gly Glu Gly Val Ser Asn Gly Tyr Lys Gly Asp Xaa 
                245                 250                 255     


Xaa Pro Asn Leu Arg Leu Leu Cys Ser Ile Xaa Gly Gly Xaa Ser Pro 
            260                 265                 270         


Ala Gln Trp Glu Asp Ile Xaa Gly Xaa Xaa Pro Leu Xaa Phe Ile Lys 
        275                 280                 285             


Asp Cys Val Ser Phe Xaa Xaa Asn Val Ser Ala Arg Phe Trp Leu Ala 
    290                 295                 300                 


Asp Cys His Gln Val Leu Glu Xaa Val Gly Leu Ala Xaa Gln Leu Tyr 
305                 310                 315                 320 


Arg Glu Leu Ile Cys Val Pro Tyr Met Ala Lys Phe Val Val Phe Ala 
                325                 330                 335     


Lys Met Asn Asp Pro Val Glu Ser Ser Leu Arg Cys Phe Cys Met Xaa 
            340                 345                 350         


Asp Asp Lys Val Asp Lys Xaa Leu Glu Gln Gln Glu Asn Phe Glu Glu 
        355                 360                 365             


Val Ala Arg Ser Lys Asp Ile Glu Val Leu Glu Gly Lys Pro Ile Tyr 
    370                 375                 380                 


Val Asp Cys Tyr Gly Asn Leu Ala Pro Leu Xaa Lys Gly Gly Gln Gln 
385                 390                 395                 400 


Leu Val Phe Asn Phe Tyr Ser Phe Lys Glu Asn Arg Leu Pro Phe Ser 
                405                 410                 415     


Ile Lys Ile Arg Asp Xaa Ser Gln Glu Pro Cys Gly Arg Leu Ser Phe 
            420                 425                 430         


Leu Lys Glu Pro Lys Xaa Xaa Lys Gly Leu Pro Gln Xaa Ala Val Cys 
        435                 440                 445             


Asn Leu Asn Ile Xaa Leu Pro Ala His Lys Lys Ile Glu Lys Xaa Asp 
    450                 455                 460                 


Arg Arg Gln Ser Phe Ala Ser Leu Ala Leu Arg Lys Arg Tyr Ser Tyr 
465                 470                 475                 480 


Leu Xaa Glu Pro Gly Met Lys Xaa Val Glu Arg Ser Xaa Gly Ala Xaa 
                485                 490                 495     


Arg Ser Leu Pro Xaa Xaa Tyr Ser Tyr Lys Pro Phe Phe Ser Xaa Arg 
            500                 505                 510         


Pro Tyr Gln Ser Trp Xaa Xaa Ala Pro Ile Xaa Val Pro Gly Pro Ala 
        515                 520                 525             


Lys Ser Gly Phe Xaa Ser Leu Ser Ser Ser Ser Ser Asn Xaa Pro Ser 
    530                 535                 540                 


Ala Ser Pro Leu Lys Ser Ile Trp Ser Val Ser Xaa Pro Ser Pro Ile 
545                 550                 555                 560 


Lys Ser Xaa Leu Gly Ala Ser Xaa Xaa Ser Ser Val Lys Ser Ile Ser 
                565                 570                 575     


Asp Val Ala Ser Pro Ile Arg Ser Phe Arg Xaa Met Ser Ser Pro Ile 
            580                 585                 590         


Lys Xaa Val Val Ser Gln Ser Pro Tyr Asn Ile Gln Val Ser Ser Gly 
        595                 600                 605             


Xaa Leu Ala Arg Ala Pro Ala Val Xaa Glu Ala Xaa Pro Leu Lys Gly 
    610                 615                 620                 


Leu Ala Ser Asn Ser Xaa Phe Ser Ser Arg Xaa Ser Pro Val Xaa Xaa 
625                 630                 635                 640 


Ala Gly Ser Leu Leu Glu Arg Ser Ser Ile Xaa Met Xaa Pro Pro Ala 
                645                 650                 655     


Ser Pro Lys Ser Asn Ile Asn Met Tyr Ser Ser Ser Leu Pro Phe Lys 
            660                 665                 670         


Ser Ile Ile Xaa Ser Ala Ala Pro Leu Ile Ser Ser Pro Leu Lys Ser 
        675                 680                 685             


Val Val Ser Pro Val Lys Ser Ala Val Asp Val Ile Ser Ser Ala Lys 
    690                 695                 700                 


Ile Xaa Met Ala Ser Ser Leu Ser Ser Pro Val Lys Gln Met Pro Gly 
705                 710                 715                 720 


His Ala Glu Val Ala Leu Val Asn Gly Ser Ile Ser Pro Leu Lys Tyr 
                725                 730                 735     


Pro Ser Ser Ser Xaa Leu Ile Asn Gly Cys Lys Ala Xaa Ala Xaa Leu 
            740                 745                 750         


Gln Glu Lys Ile Ser Ser Ala Xaa Asn Ser Val Ser Ser Val Val Ser 
        755                 760                 765             


Ala Ala Xaa Asp Xaa Val Glu Lys Val Phe Ser Xaa Xaa Xaa Ala Met 
    770                 775                 780                 


Pro Phe Ser Pro Leu Arg Ser Tyr Val Ser Ala Ala Pro Ser Ala Phe 
785                 790                 795                 800 


Gln Ser Leu Arg Xaa Pro Ser Ala Ser Ala Leu Tyr Xaa Ser Leu Gly 
                805                 810                 815     


Ser Ser Ile Ser Ala Xaa Xaa Ser Ser Val Xaa Ser Ser Ile Ile Xaa 
            820                 825                 830         


Val Pro Val Tyr Ser Val Val Asn Val Leu Pro Glu Pro Ala Leu Lys 
        835                 840                 845             


Lys Leu Pro Asp Ser Asn Ser Phe Xaa Lys Ser Ala Ala Ala Leu Leu 
    850                 855                 860                 


Ser Pro Ile Lys Xaa Leu Xaa Xaa Glu Xaa His Pro Gln Pro His Phe 
865                 870                 875                 880 


Ser Arg Xaa Ser Ser Pro Val Lys Ser Ser Leu Phe Leu Ala Pro Ser 
                885                 890                 895     


Ala Leu Lys Leu Ser Xaa Pro Ser Ser Leu Ser Ser Ser Gln Glu Ile 
            900                 905                 910         


Leu Lys Asp Val Ala Glu Met Lys Glu Asp Leu Met Arg Met Xaa Ala 
        915                 920                 925             


Ile Leu Gln Xaa Asp Val Pro Glu Glu Lys Pro Phe Gln Pro Glu Leu 
    930                 935                 940                 


Pro Lys Glu Gly Arg Ile Asp Asp Glu Glu Pro Phe Lys Ile Val Glu 
945                 950                 955                 960 


Lys Val Lys Glu Asp Leu Val Lys Val Ser Glu Ile Leu Lys Lys Asp 
                965                 970                 975     


Val Cys Val Asp Asn Lys Gly Ser Pro Lys Ser Pro Lys Ser Asp Lys 
            980                 985                 990         


Gly His Ser Pro Glu Asp Asp Trp  Ile Glu Phe Ser Ser  Glu Glu Ile 
        995                 1000                 1005             


Arg Glu  Ala Arg Gln Gln Ala  Ala Ala Ser Gln Ser  Pro Ser Leu 
    1010                 1015                 1020             


Pro Glu  Arg Val Gln Val Lys  Ala Lys Ala Ala Ser  Glu Lys Asp 
    1025                 1030                 1035             


Tyr Asn  Leu Xaa Lys Val Ile  Asp Tyr Leu Xaa Asn  Asp Ile Gly 
    1040                 1045                 1050             


Ser Ser  Ser Leu Xaa Asn Leu  Lys Tyr Lys Phe Glu  Asp Ala Lys 
    1055                 1060                 1065             


Lys Asp  Gly Glu Glu Arg Gln  Lys Arg Val Leu Lys  Pro Ala Ile 
    1070                 1075                 1080             


Ala Leu  Gln Glu His Lys Leu  Lys Met Pro Pro Ala  Ser Met Arg 
    1085                 1090                 1095             


Xaa Ser  Xaa Ser Glu Lys Glu  Leu Cys Lys Met Ala  Asp Ser Phe 
    1100                 1105                 1110             


Phe Gly  Xaa Asp Xaa Ile Leu  Glu Ser Pro Asp Asp  Phe Ser Gln 
    1115                 1120                 1125             


His Asp  Gln Asp Lys Ser Pro  Leu Ser Asp Ser Gly  Phe Glu Xaa 
    1130                 1135                 1140             


Arg Ser  Glu Lys Xaa Pro Ser  Ala Pro Gln Ser Ala  Glu Ser Xaa 
    1145                 1150                 1155             


Gly Pro  Lys Pro Leu Phe His  Glu Val Pro Ile Pro  Pro Val Ile 
    1160                 1165                 1170             


Xaa Glu  Xaa Arg Xaa Glu Val  Val His Val Ile Arg  Ser Tyr Asp 
    1175                 1180                 1185             


Pro Ser  Ala Gly Asp Val Pro  Gln Xaa Gln Pro Glu  Glu Pro Val 
    1190                 1195                 1200             


Ser Pro  Lys Pro Ser Pro Xaa  Phe Met Glu Leu Glu  Pro Lys Pro 
    1205                 1210                 1215             


Xaa Xaa  Ser Ser Ile Lys Glu  Lys Val Lys Ala Phe  Gln Met Lys 
    1220                 1225                 1230             


Ala Ser  Ser Glu Glu Asp Asp  His Asn Arg Val Leu  Ser Lys Gly 
    1235                 1240                 1245             


Met Arg  Val Lys Glu Glu Xaa  His Ile Xaa Xaa Xaa  Xaa Arg Met 
    1250                 1255                 1260             


Val Tyr  His Ser Pro Pro Gly  Gly Glu Gly Ala Ser  Glu Arg Ile 
    1265                 1270                 1275             


Glu Glu  Xaa Met Ser Val His  Asp Ile Met Lys Ala  Phe Gln Ser 
    1280                 1285                 1290             


Gly Arg  Asp Pro Ser Lys Glu  Leu Ala Gly Leu Phe  Glu His Lys 
    1295                 1300                 1305             


Ser Ala  Val Ser Pro Asp Val  His Lys Ser Ala Ala  Glu Xaa Ser 
    1310                 1315                 1320             


Ala Gln  His Ala Glu Lys Asp  Asn Gln Met Lys Pro  Lys Leu Glu 
    1325                 1330                 1335             


Arg Ile  Ile Glu Val His Ile  Glu Lys Gly Pro Gln  Ser Pro Cys 
    1340                 1345                 1350             


Glu Arg  Xaa Asp Ile Arg Met  Ala Ile Val Ala Asp  His Leu Gly 
    1355                 1360                 1365             


Leu Ser  Trp Xaa Glu Leu Ala  Arg Glu Leu Asn Phe  Ser Val Asp 
    1370                 1375                 1380             


Glu Ile  Asn Gln Ile Arg Val  Glu Asn Pro Asn Ser  Leu Ile Ser 
    1385                 1390                 1395             


Gln Ser  Phe Met Leu Leu Lys  Lys Trp Val Xaa Arg  Asp Gly Lys 
    1400                 1405                 1410             


Asn Ala  Xaa Xaa Asp Ala Leu  Xaa Ser Val Leu Xaa  Lys Ile Asn 
    1415                 1420                 1425             


Arg Ile  Asp Ile Val Xaa Leu  Leu Glu Gly Pro Ile  Phe Asp Tyr 
    1430                 1435                 1440             


Gly Asn  Ile Ser Gly Xaa Arg  Ser Phe Ala Asp Glu  Asn Asn Val 
    1445                 1450                 1455             


Phe His  Asp Pro Val Asp Gly  Trp Gln Asn Glu Xaa  Ser Ser Gly 
    1460                 1465                 1470             


Asn Leu  Glu Ser Cys Ala Gln  Ala Arg Arg Val Xaa  Gly Gly Leu 
    1475                 1480                 1485             


Leu Asp  Arg Leu Asp Asp Ser  Pro Asp Gln Cys Arg  Asp Ser Ile 
    1490                 1495                 1500             


Xaa Ser  Tyr Leu Lys Gly Glu  Ala Gly Lys Phe Glu  Ala Asn Gly 
    1505                 1510                 1515             


Ser His  Xaa Glu Ile Xaa Pro  Glu Ala Lys Xaa Lys  Ser Tyr Phe 
    1520                 1525                 1530             


Pro Glu  Ser Gln Asn Asp Val  Gly Lys Gln Ser Xaa  Lys Glu Xaa 
    1535                 1540                 1545             


Leu Lys  Pro Lys Ile His Gly  Ser Gly His Val Glu  Glu Pro Ala 
    1550                 1555                 1560             


Ser Pro  Leu Ala Ala Tyr Gln  Lys Ser Leu Glu Glu  Xaa Ser Lys 
    1565                 1570                 1575             


Leu Ile  Ile Glu Glu Xaa Lys  Pro Cys Val Pro Val  Ser Met Lys 
    1580                 1585                 1590             


Lys Met  Ser Arg Xaa Ser Pro  Ala Asp Gly Lys Pro  Arg Leu Ser 
    1595                 1600                 1605             


Leu His  Glu Glu Glu Gly Ser  Ser Gly Ser Glu Gln  Lys Gln Gly 
    1610                 1615                 1620             


Glu Gly  Phe Lys Val Lys Xaa  Lys Lys Glu Ile Arg  His Val Glu 
    1625                 1630                 1635             


Lys Lys  Ser His Ser 
    1640             


<210> 2332
<211> 322
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<400> 2332
Xaa Gly Pro Asp Glu Asp Lys Pro Pro Ser Lys Ser Ser Ser Ser Glu 
1               5                   10                  15      


Lys Xaa Pro Asp Lys Xaa Asp Gln Lys Ser Gly Ala Gln Phe Phe Xaa 
            20                  25                  30          


Leu Glu Gly Arg His Pro Asp Arg Ser Val Phe Pro Asp Xaa Tyr Phe 
        35                  40                  45              


Ser Tyr Lys Val Asp Glu Glu Phe Ala Xaa Pro Phe Lys Xaa Val Ala 
    50                  55                  60                  


Xaa Lys Gly Leu Asp Phe Asp Pro Trp Ser Asn Asn Arg Gly Asp Asp 
65                  70                  75                  80  


Glu Val Phe Asp Ser Lys Ser Arg Glu Asp Glu Xaa Lys Pro Phe Gly 
                85                  90                  95      


Leu Ala Val Glu Asp Arg Ser Pro Ala Xaa Xaa Pro Asp Xaa Xaa Pro 
            100                 105                 110         


Ala Arg Xaa Pro Xaa Asp Glu Ser Xaa Pro Xaa Ser Glu Pro Asn Pro 
        115                 120                 125             


Phe Pro Phe His Glu Gly Lys Met Phe Glu Met Xaa Arg Ser Gly Ala 
    130                 135                 140                 


Ile Asp Met Ser Lys Arg Asp Phe Val Glu Glu Arg Leu Gln Phe Phe 
145                 150                 155                 160 


Gln Ile Gly Pro Gln Ser Pro Cys Glu Arg Xaa Asp Ile Arg Met Ala 
                165                 170                 175     


Ile Val Ala Asp His Leu Gly Leu Ser Trp Xaa Glu Leu Ala Arg Glu 
            180                 185                 190         


Leu Asn Phe Ser Val Asp Glu Ile Asn Gln Ile Arg Val Glu Asn Pro 
        195                 200                 205             


Asn Ser Leu Ile Ser Gln Ser Phe Met Leu Leu Lys Lys Trp Val Xaa 
    210                 215                 220                 


Arg Asp Gly Lys Asn Ala Xaa Xaa Asp Ala Leu Xaa Ser Val Leu Xaa 
225                 230                 235                 240 


Lys Ile Asn Arg Ile Asp Ile Val Xaa Leu Leu Glu Gly Pro Ile Phe 
                245                 250                 255     


Asp Tyr Gly Asn Ile Ser Gly Xaa Arg Ser Phe Ala Asp Glu Asn Asn 
            260                 265                 270         


Val Phe His Asp Pro Val Asp Gly Trp Gln Asn Glu Xaa Ser Ser Gly 
        275                 280                 285             


Asn Leu Glu Ser Cys Ala Gln Ala Arg Arg Val Xaa Gly Gly Leu Leu 
    290                 295                 300                 


Asp Arg Leu Asp Asp Ser Pro Asp Gln Cys Arg Asp Ser Ile Xaa Ser 
305                 310                 315                 320 


Tyr Leu 
        


<210> 2333
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<400> 2333
Xaa Ile Glu Lys Xaa Asp Arg Arg Gln Ser Phe Ala Ser Leu Ala Leu 
1               5                   10                  15      


Arg Lys Arg Tyr Ser Tyr Leu Xaa Glu Pro Gly Met Ser Pro Gln Ser 
            20                  25                  30          


Pro Cys Glu Arg Xaa Asp Ile Arg Met Ala Ile Val Ala Asp His Leu 
        35                  40                  45              


Gly Leu Ser Trp Xaa Glu Leu Ala Arg Glu Leu Asn Phe Ser Val Asp 
    50                  55                  60                  


Glu Ile Asn Gln Ile Arg Val Glu Asn Pro Asn Ser Leu Ile Ser Gln 
65                  70                  75                  80  


Ser Phe Met Leu Leu Lys Lys Trp Val Xaa Arg Asp Gly Lys Asn Ala 
                85                  90                  95      


Xaa Xaa Asp Ala Leu Xaa Ser Val Leu Xaa Lys Ile Asn Arg Ile Asp 
            100                 105                 110         


Ile Val Xaa Leu Leu Glu Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser 
        115                 120                 125             


Gly Xaa Arg Ser Phe Ala Asp Glu Asn Asn Val Phe His Asp Pro Val 
    130                 135                 140                 


Asp Asp Gly Pro Pro Val Val Xaa Ala Glu Asp Ala Ser Leu Glu Asp 
145                 150                 155                 160 


Ser Lys Leu Glu Asp Ser Val Pro Leu Xaa Glu Met Pro Glu Ala Val 
                165                 170                 175     


Asp Val Asp Glu Ser Gln Leu Glu Asn Val Cys Leu 
            180                 185             


<210> 2334
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<400> 2334
Xaa Leu Ala Arg Glu Leu Asn Phe Ser Val Asp Glu Ile Asn Gln Ile 
1               5                   10                  15      


Arg Val Glu Asn Pro Asn Ser Leu Ile Ser Gln Ser Phe Met Leu Leu 
            20                  25                  30          


Lys Lys Trp Val Xaa Arg Asp Gly Lys Asn Ala Xaa Xaa Asp Ala Leu 
        35                  40                  45              


Xaa Ser Val Leu Xaa Lys Ile Asn Arg Ile Asp Ile Val Xaa Leu Leu 
    50                  55                  60                  


Glu Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser Gly Xaa Arg Ser Phe 
65                  70                  75                  80  


Ala Asp Glu Asn Asn Val Phe His Asp Pro Val Asp Gly Asn Arg Ile 
                85                  90                  95      


<210> 2335
<211> 217
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<400> 2335
Xaa Leu Ala Arg Glu Leu Asn Phe Ser Val Asp Glu Ile Asn Gln Ile 
1               5                   10                  15      


Arg Val Glu Asn Pro Asn Ser Leu Ile Ser Gln Ser Phe Met Leu Leu 
            20                  25                  30          


Lys Lys Trp Val Xaa Arg Asp Gly Lys Asn Ala Xaa Xaa Asp Ala Leu 
        35                  40                  45              


Xaa Ser Val Leu Xaa Lys Ile Asn Arg Ile Asp Ile Val Xaa Leu Leu 
    50                  55                  60                  


Glu Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser Gly Xaa Arg Ser Phe 
65                  70                  75                  80  


Ala Asp Glu Asn Asn Val Phe His Asp Pro Val Asp Val Ser Pro Asn 
                85                  90                  95      


Val Leu Ser Ser Ile Gly Tyr Pro Ser Leu Gln Val Glu Leu Glu Xaa 
            100                 105                 110         


Pro Xaa Gly Leu His Tyr Xaa Pro Pro Xaa Pro Phe Gln Gln Asp Asp 
        115                 120                 125             


Tyr Phe Ser Asp Ile Ser Ser Ile Glu Ser Pro Leu Arg Xaa Pro Ser 
    130                 135                 140                 


Arg Leu Ser Asp Gly Leu Val Pro Ser Gln Gly Asn Ile Glu His Ser 
145                 150                 155                 160 


Ala Asp Gly Pro Pro Val Val Xaa Ala Glu Asp Ala Ser Leu Glu Asp 
                165                 170                 175     


Ser Lys Leu Glu Asp Ser Val Pro Leu Xaa Glu Met Pro Glu Ala Val 
            180                 185                 190         


Asp Val Asp Glu Ser Gln Leu Glu Asn Val Cys Leu Ser Trp Gln Asn 
        195                 200                 205             


Glu Xaa Ser Ser Gly Asn Leu Glu Ser 
    210                 215         


<210> 2336
<211> 973
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<400> 2336
Xaa Pro Val Ile Val Glu Ile Pro His Phe Gly Ser Met Arg Gly Lys 
1               5                   10                  15      


Glu Arg Glu Leu Ile Val Leu Arg Ser Glu Asn Gly Glu Xaa Trp Lys 
            20                  25                  30          


Glu His Gln Phe Asp Ser Lys Asn Glu Asp Leu Xaa Glu Leu Leu Asn 
        35                  40                  45              


Gly Met Asp Glu Glu Leu Asp Ser Pro Glu Glu Leu Gly Lys Lys Arg 
    50                  55                  60                  


Ile Cys Arg Ile Ile Xaa Lys Asp Phe Pro Gln Tyr Phe Ala Val Val 
65                  70                  75                  80  


Ser Arg Ile Lys Gln Glu Ser Asn Gln Ile Gly Pro Glu Gly Gly Ile 
                85                  90                  95      


Leu Ser Ser Xaa Xaa Val Pro Leu Val Gln Ala Ser Phe Pro Glu Gly 
            100                 105                 110         


Ala Leu Xaa Lys Arg Ile Arg Val Gly Leu Gln Ala Gln Pro Val Pro 
        115                 120                 125             


Asp Glu Ile Val Lys Lys Ile Leu Gly Asn Lys Ala Xaa Phe Ser Pro 
    130                 135                 140                 


Ile Val Xaa Val Glu Pro Arg Arg Arg Lys Phe His Lys Pro Ile Xaa 
145                 150                 155                 160 


Met Xaa Ile Pro Val Pro Pro Pro Ser Gly Glu Gly Val Ser Asn Gly 
                165                 170                 175     


Tyr Lys Gly Asp Xaa Xaa Pro Asn Leu Arg Leu Leu Cys Ser Ile Xaa 
            180                 185                 190         


Gly Gly Xaa Ser Pro Ala Gln Trp Glu Asp Ile Xaa Gly Xaa Xaa Pro 
        195                 200                 205             


Leu Xaa Phe Ile Lys Asp Cys Val Ser Phe Xaa Xaa Asn Val Ser Ala 
    210                 215                 220                 


Arg Phe Trp Leu Ala Asp Cys His Gln Val Leu Glu Xaa Val Gly Leu 
225                 230                 235                 240 


Ala Xaa Gln Leu Tyr Arg Glu Leu Ile Cys Val Pro Tyr Met Ala Lys 
                245                 250                 255     


Phe Val Val Phe Ala Lys Met Asn Asp Pro Val Glu Ser Ser Leu Arg 
            260                 265                 270         


Cys Phe Cys Met Xaa Asp Asp Lys Val Asp Lys Xaa Leu Glu Gln Gln 
        275                 280                 285             


Glu Asn Phe Glu Glu Val Ala Arg Ser Lys Asp Ile Glu Val Leu Glu 
    290                 295                 300                 


Gly Lys Pro Ile Tyr Val Asp Cys Tyr Gly Asn Leu Ala Pro Leu Xaa 
305                 310                 315                 320 


Lys Gly Gly Gln Gln Leu Val Phe Asn Phe Tyr Ser Phe Lys Glu Asn 
                325                 330                 335     


Arg Leu Pro Phe Ser Ile Lys Ile Arg Asp Xaa Ser Gln Glu Pro Cys 
            340                 345                 350         


Gly Arg Leu Ser Phe Leu Lys Glu Pro Lys Xaa Xaa Lys Gly Leu Pro 
        355                 360                 365             


Gln Xaa Ala Val Cys Asn Leu Asn Ile Xaa Leu Pro Ala His Lys Lys 
    370                 375                 380                 


Glu Xaa Glu Ser Asp Gln Asp Asp Glu Ile Glu Lys Xaa Asp Arg Arg 
385                 390                 395                 400 


Gln Ser Phe Ala Ser Leu Ala Leu Arg Pro Gln Ser Pro Cys Glu Arg 
                405                 410                 415     


Xaa Asp Ile Arg Met Ala Ile Val Ala Asp His Leu Gly Leu Ser Trp 
            420                 425                 430         


Xaa Glu Leu Ala Arg Glu Leu Asn Phe Ser Val Asp Glu Ile Asn Gln 
        435                 440                 445             


Ile Arg Val Glu Asn Pro Asn Ser Leu Ile Ser Gln Ser Phe Met Leu 
    450                 455                 460                 


Leu Lys Lys Trp Val Xaa Arg Asp Gly Lys Asn Ala Xaa Xaa Asp Ala 
465                 470                 475                 480 


Leu Xaa Ser Val Leu Xaa Lys Ile Asn Arg Ile Asp Ile Val Xaa Leu 
                485                 490                 495     


Leu Glu Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser Gly Xaa Arg Ser 
            500                 505                 510         


Phe Ala Asp Glu Asn Asn Val Phe His Asp Pro Val Asp Gly Tyr Pro 
        515                 520                 525             


Ser Leu Gln Val Glu Leu Glu Xaa Pro Xaa Gly Leu His Tyr Xaa Pro 
    530                 535                 540                 


Pro Xaa Pro Phe Gln Gln Asp Asp Tyr Phe Ser Asp Ile Ser Ser Ile 
545                 550                 555                 560 


Glu Ser Pro Leu Arg Xaa Pro Ser Arg Leu Ser Asp Gly Leu Val Pro 
                565                 570                 575     


Ser Gln Gly Asn Ile Glu His Ser Ala Asp Gly Pro Pro Val Val Xaa 
            580                 585                 590         


Ala Glu Asp Ala Ser Leu Glu Asp Ser Lys Leu Glu Asp Ser Val Pro 
        595                 600                 605             


Leu Xaa Glu Met Pro Glu Ala Val Asp Val Asp Glu Ser Gln Leu Glu 
    610                 615                 620                 


Asn Val Cys Leu Ser Glu Tyr Pro Gln Tyr Leu Gly Asn Leu Ala Gly 
625                 630                 635                 640 


Ser Pro Lys Asp Val Lys Pro Ala Glu Pro Arg Lys Leu Gly Val Ser 
                645                 650                 655     


Ser Glu Gln Gln Glu Lys Gly Lys Ser Gly Pro Asp Glu Glu Met Met 
            660                 665                 670         


Glu Glu Lys Leu Lys Ser Leu Phe Glu Asp Ile Gln Leu Glu Glu Gly 
        675                 680                 685             


Val Glu Ser Glu Glu Met Xaa Glu Glu Lys Val Gln Ala Ile Leu Lys 
    690                 695                 700                 


Arg Val Gln Gln Ala Glu Leu Glu Met Ser Ser Ile Xaa Gly Trp Gln 
705                 710                 715                 720 


Asn Glu Xaa Ser Ser Gly Asn Leu Glu Ser Cys Ala Gln Ala Arg Arg 
                725                 730                 735     


Val Xaa Gly Gly Leu Leu Asp Arg Leu Asp Asp Ser Pro Asp Gln Cys 
            740                 745                 750         


Arg Asp Ser Ile Xaa Ser Tyr Leu Lys Gly Glu Ala Gly Lys Phe Glu 
        755                 760                 765             


Ala Asn Gly Ser His Xaa Glu Ile Xaa Pro Glu Ala Lys Xaa Lys Ser 
    770                 775                 780                 


Tyr Phe Pro Glu Ser Gln Asn Asp Val Gly Lys Gln Ser Xaa Lys Glu 
785                 790                 795                 800 


Xaa Leu Lys Pro Lys Ile His Gly Ser Gly His Val Glu Glu Pro Ala 
                805                 810                 815     


Ser Pro Leu Ala Ala Tyr Gln Lys Ser Leu Glu Glu Xaa Ser Lys Leu 
            820                 825                 830         


Ile Ile Glu Glu Xaa Lys Pro Cys Val Pro Val Ser Met Lys Lys Met 
        835                 840                 845             


Ser Arg Xaa Ser Pro Ala Asp Gly Lys Pro Arg Leu Ser Leu His Glu 
    850                 855                 860                 


Glu Glu Gly Ser Ser Gly Ser Glu Gln Lys Asp Leu Lys Asp Ser Glu 
865                 870                 875                 880 


Ser Asp Ser Ser Ser Glu Glu Glu Arg Arg Val Xaa Xaa Arg Val Ile 
                885                 890                 895     


Arg Arg Arg Leu Ile Ile Lys Gly Glu Glu Ala Lys Asn Ile Pro Gly 
            900                 905                 910         


Glu Ser Val Xaa Glu Glu Gln Phe Xaa Asp Glu Glu Gly Asn Leu Ile 
        915                 920                 925             


Xaa Arg Lys Ile Xaa Arg Lys Val Leu Arg Arg Ile Val Ile Pro Gln 
    930                 935                 940                 


Glu Arg Lys Arg Asp Asp Val Gln Gly Glu Gly Phe Lys Val Lys Xaa 
945                 950                 955                 960 


Lys Lys Glu Ile Arg His Val Glu Lys Lys Ser His Ser 
                965                 970             


<210> 2337
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 2337
Xaa Ser Pro Leu Ala Ala Tyr Gln Lys Ser Leu Glu Glu Xaa Ser Lys 
1               5                   10                  15      


Leu Ile Ile Glu Glu Xaa Lys Pro Cys Val Pro Val Ser Met Lys Lys 
            20                  25                  30          


Met Ser Arg Xaa Ser Pro Ala Asp Gly Lys Pro Arg Leu Ser Leu His 
        35                  40                  45              


Glu Glu Glu Gly Ser Ser Gly Ser Glu Gln Lys Val Lys Ser Pro Gly 
    50                  55                  60                  


Ala Ala Pro Xaa Arg Met Xaa Ala Cys Cys Tyr Lys Asp Leu Lys Asp 
65                  70                  75                  80  


Ser Glu Ser Asp Ser Ser Ser Glu Glu Glu Arg Arg Val Xaa Xaa Arg 
                85                  90                  95      


Val Ile Arg Arg Arg Leu Ile Ile Lys Gly Glu Glu Ala Lys Asn Ile 
            100                 105                 110         


Pro Gly Glu Ser Val Xaa Glu Glu Gln Phe Xaa Asp Glu Glu Gly Asn 
        115                 120                 125             


Leu Ile Xaa Arg Lys Ile Xaa Arg Lys Val Leu Arg Arg Ile Val Ile 
    130                 135                 140                 


Pro Gln Glu Arg Lys Arg Asp Asp Val Gln Gly Glu Gly Phe Lys Val 
145                 150                 155                 160 


Lys Xaa Lys Lys Glu Ile Arg His Val Glu Lys Lys Ser His Ser 
                165                 170                 175 


<210> 2338
<211> 196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<400> 2338
Xaa Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp 
1               5                   10                  15      


Ala Arg Gly Gly Ser Met Arg Gly Ser Arg His His Gly Met Arg Ile 
            20                  25                  30          


Ile Ile Pro Pro Arg Lys Cys Xaa Ala Pro Xaa Arg Ile Xaa Cys Arg 
        35                  40                  45              


Leu Val Lys Arg His Lys Leu Ala Asn Pro Pro Pro Met Val Glu Gly 
    50                  55                  60                  


Glu Gly Leu Ala Ser Arg Leu Val Glu Met Gly Pro Ala Gly Ala Gln 
65                  70                  75                  80  


Phe Leu Gly Lys Leu His Leu Pro Xaa Asn Pro Pro Pro Val Asn Glu 
                85                  90                  95      


Gly Glu Ser Leu Val Ser Arg Ile Leu Gln Leu Gly Pro Gln Gly Xaa 
            100                 105                 110         


Lys Phe Ile Gly Pro Val Ile Val Glu Ile Pro His Phe Gly Ser Met 
        115                 120                 125             


Arg Gly Lys Glu Arg Glu Leu Ile Val Leu Arg Ser Glu Asn Gly Glu 
    130                 135                 140                 


Xaa Trp Lys Glu His Gln Phe Asp Ser Lys Asn Glu Asp Leu Xaa Glu 
145                 150                 155                 160 


Leu Leu Asn Gly Met Asp Glu Glu Leu Asp Ser Pro Glu Glu Leu Gly 
                165                 170                 175     


Lys Lys Arg Ile Cys Arg Ile Ile Xaa Lys Asp Phe Pro Gln Tyr Phe 
            180                 185                 190         


Ala Val Val Ser 
        195     


<210> 2339
<211> 241
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<400> 2339
Xaa Xaa Val Ala Xaa Lys Gly Leu Asp Phe Asp Pro Trp Ser Asn Asn 
1               5                   10                  15      


Arg Gly Asp Asp Glu Val Phe Asp Ser Lys Ser Arg Glu Asp Glu Xaa 
            20                  25                  30          


Lys Pro Phe Gly Leu Ala Val Glu Asp Arg Ser Pro Ala Xaa Xaa Pro 
        35                  40                  45              


Asp Xaa Xaa Pro Ala Arg Xaa Pro Xaa Asp Glu Ser Xaa Pro Xaa Ser 
    50                  55                  60                  


Glu Pro Asn Pro Phe Pro Phe His Glu Gly Lys Met Phe Glu Met Xaa 
65                  70                  75                  80  


Arg Ser Gly Ala Ile Asp Met Ser Lys Arg Asp Phe Val Glu Glu Arg 
                85                  90                  95      


Leu Gln Phe Phe Gln Ile Gly Pro Gln Ser Pro Cys Glu Arg Xaa Asp 
            100                 105                 110         


Ile Arg Met Ala Ile Val Ala Asp His Leu Gly Leu Ser Trp Xaa Glu 
        115                 120                 125             


Leu Ala Arg Glu Leu Asn Phe Ser Val Asp Glu Ile Asn Gln Ile Arg 
    130                 135                 140                 


Val Glu Asn Pro Asn Ser Leu Ile Ser Gln Ser Phe Met Leu Leu Lys 
145                 150                 155                 160 


Lys Trp Val Xaa Arg Asp Gly Lys Asn Ala Xaa Xaa Asp Ala Leu Xaa 
                165                 170                 175     


Ser Val Leu Xaa Lys Ile Asn Arg Ile Asp Ile Val Xaa Leu Leu Glu 
            180                 185                 190         


Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser Gly Xaa Arg Ser Phe Ala 
        195                 200                 205             


Asp Glu Asn Asn Val Phe His Asp Pro Val Asp Gly Tyr Pro Ser Leu 
    210                 215                 220                 


Gln Val Glu Leu Glu Xaa Pro Xaa Gly Leu His Tyr Xaa Pro Pro Xaa 
225                 230                 235                 240 


Pro 
    


<210> 2340
<211> 178
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 2340
Xaa Trp Gln Asn Glu Xaa Ser Ser Gly Asn Leu Glu Ser Cys Ala Gln 
1               5                   10                  15      


Ala Arg Arg Val Xaa Gly Gly Leu Leu Asp Arg Leu Asp Asp Ser Pro 
            20                  25                  30          


Asp Gln Cys Arg Asp Ser Ile Xaa Ser Tyr Leu Lys Gly Glu Ala Gly 
        35                  40                  45              


Lys Phe Glu Ala Asn Gly Ser His Xaa Glu Ile Xaa Pro Glu Ala Lys 
    50                  55                  60                  


Xaa Lys Ser Tyr Phe Pro Glu Ser Gln Asn Asp Val Gly Lys Gln Ser 
65                  70                  75                  80  


Xaa Lys Glu Xaa Leu Lys Pro Lys Ile His Gly Ser Gly His Val Glu 
                85                  90                  95      


Glu Pro Ala Ser Pro Leu Ala Ala Tyr Gln Lys Ser Leu Glu Glu Xaa 
            100                 105                 110         


Ser Lys Leu Ile Ile Glu Glu Xaa Lys Pro Cys Val Pro Val Ser Met 
        115                 120                 125             


Lys Lys Met Ser Arg Xaa Ser Pro Ala Asp Gly Lys Pro Arg Leu Ser 
    130                 135                 140                 


Leu His Glu Glu Glu Gly Ser Ser Gly Ser Glu Gln Lys Gly Glu Gly 
145                 150                 155                 160 


Phe Lys Val Lys Xaa Lys Lys Glu Ile Arg His Val Glu Lys Lys Ser 
                165                 170                 175     


His Ser 
        


<210> 2341
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 2341
Ile Gly Arg Arg Val Asn Xaa Arg Ala Arg Asn His Val Gly Arg Val 
1               5                   10                  15      


Ala Leu His Trp Ala Ala Gly Ala Gly His Glu Gln Ala Val Arg Leu 
            20                  25                  30          


Leu Leu Glu His Glu Ala Ala Val Asp Glu Glu Asp Ala Val Gly Ala 
        35                  40                  45              


Leu Xaa Glu Glu Gly Asn Xaa Ala Leu His Leu Ala Ala Gly Arg Gly 
    50                  55                  60                  


His Met Ala Val Leu Gln Arg Leu Val Asp Ile Gly Leu Asp Leu Glu 
65                  70                  75                  80  


Glu Gln Asn Ala Glu Gly Leu Xaa Ala Leu His Ser Ala Ala Gly Gly 
                85                  90                  95      


Ser His Pro Asp Cys Val Gln Leu Leu Leu Arg Ala Gly Ser Xaa Val 
            100                 105                 110         


Asn Ala Leu Xaa Gln Val Ala Arg Pro Ser Gln Asp Cys Gly Arg Leu 
        115                 120                 125             


Leu Ala Ala Glu Pro 
    130             


<210> 2342
<211> 399
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<400> 2342
Met Asn Ala Leu Leu Leu Ser Ala Trp Phe Gly His Leu Arg Ile Leu 
1               5                   10                  15      


Gln Ile Leu Val Asn Ser Gly Ala Lys Ile His Cys Glu Ser Lys Asp 
            20                  25                  30          


Gly Leu Xaa Leu Leu His Cys Ala Ala Gln Lys Gly His Val Pro Val 
        35                  40                  45              


Leu Ala Phe Ile Met Glu Asp Leu Glu Asp Val Ala Leu Asp His Val 
    50                  55                  60                  


Asp Lys Leu Gly Arg Xaa Ala Phe His Arg Ala Ala Glu His Gly Gln 
65                  70                  75                  80  


Leu Asp Ala Leu Asp Phe Leu Val Gly Ser Gly Cys Asp His Asn Val 
                85                  90                  95      


Lys Asp Lys Glu Gly Asn Xaa Ala Leu His Leu Ala Ala Gly Arg Gly 
            100                 105                 110         


His Met Ala Val Leu Gln Arg Leu Val Asp Ile Gly Leu Asp Leu Glu 
        115                 120                 125             


Glu Gln Asn Ala Glu Gly Leu Xaa Ala Leu His Ser Ala Ala Gly Gly 
    130                 135                 140                 


Ser His Pro Asp Cys Val Gln Leu Leu Leu Arg Ala Gly Ser Xaa Val 
145                 150                 155                 160 


Asn Ala Leu Xaa Gln Lys Asn Leu Ser Cys Leu His Tyr Ala Ala Leu 
                165                 170                 175     


Ser Gly Ser Glu Asp Val Ser Arg Val Leu Ile His Ala Gly Gly Cys 
            180                 185                 190         


Ala Asn Val Val Asp His Gln Gly Ala Ser Pro Leu His Leu Ala Val 
        195                 200                 205             


Arg His Asn Phe Pro Ala Leu Val Arg Leu Leu Ile Asn Ser Asp Ser 
    210                 215                 220                 


Asp Val Asn Ala Val Asp Asn Arg Gln Gln Xaa Pro Leu His Leu Ala 
225                 230                 235                 240 


Ala Glu His Ala Trp Gln Asp Ile Ala Asp Met Leu Leu Ile Ala Gly 
                245                 250                 255     


Val Asp Leu Asn Leu Arg Asp Lys Asp His Pro Ser Asp Pro Ser Gly 
            260                 265                 270         


Lys Ser Leu Ser Phe Lys Gln Asp His Arg Gln Glu Xaa Gln Gln Leu 
        275                 280                 285             


Arg Ser Val Leu Trp Arg Leu Ala Ser Arg Tyr Leu Gln Pro Arg Glu 
    290                 295                 300                 


Trp Lys Lys Leu Ala Tyr Ser Trp Glu Phe Xaa Glu Ala His Val Asp 
305                 310                 315                 320 


Ala Ile Glu Gln Gln Trp Xaa Gly Xaa Arg Ser Tyr Gln Glu His Gly 
                325                 330                 335     


His Arg Met Leu Leu Ile Trp Leu His Gly Val Ala Xaa Ala Gly Glu 
            340                 345                 350         


Asn Pro Ser Lys Ala Leu Phe Glu Gly Leu Val Ala Ile Gly Arg Arg 
        355                 360                 365             


Asp Leu Ala Gly Trp Ser Xaa Met Ala Arg Ser Gln Leu Xaa Ala Xaa 
    370                 375                 380                 


Ser Ala Ser Arg Val Gln Met Ile Leu Val Pro Gln Pro Pro Glu 
385                 390                 395                 


<210> 2343
<211> 423
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<400> 2343
Met Asn Ala Leu Leu Leu Ser Ala Trp Phe Gly His Leu Arg Ile Leu 
1               5                   10                  15      


Gln Ile Leu Val Asn Ser Gly Ala Lys Ile His Cys Glu Ser Lys Asp 
            20                  25                  30          


Gly Leu Xaa Leu Leu His Cys Ala Ala Gln Lys Gly His Val Pro Val 
        35                  40                  45              


Leu Ala Phe Ile Met Glu Asp Leu Glu Asp Val Ala Leu Asp His Val 
    50                  55                  60                  


Asp Lys Leu Gly Arg Xaa Ala Phe His Arg Ala Ala Glu His Gly Gln 
65                  70                  75                  80  


Leu Asp Ala Leu Asp Phe Leu Val Gly Ser Gly Cys Asp His Asn Val 
                85                  90                  95      


Lys Asp Lys Glu Gly Asn Xaa Ala Leu His Leu Ala Ala Gly Arg Gly 
            100                 105                 110         


His Met Ala Val Leu Gln Arg Leu Val Asp Ile Gly Leu Asp Leu Glu 
        115                 120                 125             


Glu Gln Asn Ala Glu Gly Leu Xaa Ala Leu His Ser Ala Ala Gly Gly 
    130                 135                 140                 


Ser His Pro Asp Cys Val Gln Leu Leu Leu Arg Ala Gly Ser Xaa Val 
145                 150                 155                 160 


Asn Ala Leu Xaa Gln Lys Asn Leu Ser Cys Leu His Tyr Ala Ala Leu 
                165                 170                 175     


Ser Gly Ser Glu Asp Val Ser Arg Val Leu Ile His Ala Gly Gly Cys 
            180                 185                 190         


Ala Asn Val Val Asp His Gln Gly Ala Ser Pro Leu His Leu Ala Val 
        195                 200                 205             


Arg His Asn Phe Pro Ala Leu Val Arg Leu Leu Ile Asn Ser Asp Ser 
    210                 215                 220                 


Asp Val Asn Ala Val Asp Asn Arg Gln Gln Xaa Pro Leu His Leu Ala 
225                 230                 235                 240 


Ala Glu His Ala Trp Gln Asp Ile Ala Asp Met Leu Leu Ile Ala Gly 
                245                 250                 255     


Val Asp Leu Asn Leu Arg Asp Lys Gln Gly Lys Xaa Ala Leu Ala Val 
            260                 265                 270         


Ala Val Arg Ser Asn His Val Ser Leu Val Asp Met Ile Ile Lys Ala 
        275                 280                 285             


Asp Arg Phe Tyr Arg Trp Glu Lys Asp His Pro Ser Asp Pro Ser Gly 
    290                 295                 300                 


Lys Ser Leu Ser Phe Lys Gln Asp His Arg Gln Glu Xaa Gln Gln Leu 
305                 310                 315                 320 


Arg Ser Val Leu Trp Arg Leu Ala Ser Arg Tyr Leu Gln Pro Arg Glu 
                325                 330                 335     


Trp Lys Lys Leu Ala Tyr Ser Trp Glu Phe Xaa Glu Ala His Val Asp 
            340                 345                 350         


Ala Ile Glu Gln Gln Trp Xaa Gly Xaa Arg Ser Tyr Gln Glu His Gly 
        355                 360                 365             


His Arg Met Leu Leu Ile Trp Leu His Gly Val Ala Xaa Ala Gly Glu 
    370                 375                 380                 


Asn Pro Ser Lys Ala Leu Phe Glu Gly Leu Val Ala Ile Gly Arg Arg 
385                 390                 395                 400 


Asp Leu Ala Glu Asn Ile Arg Lys Lys Ala Asn Ala Ala Pro Ser Ala 
                405                 410                 415     


Pro Arg Arg Cys Xaa Ala Met 
            420             


<210> 2344
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<400> 2344
Met Asn Ala Leu Leu Leu Ser Ala Trp Phe Gly His Leu Arg Ile Leu 
1               5                   10                  15      


Gln Ile Leu Val Asn Ser Gly Ala Lys Ile His Cys Glu Ser Lys Asp 
            20                  25                  30          


Gly Leu Xaa Leu Leu His Cys Ala Ala Gln Lys Gly His Val Pro Val 
        35                  40                  45              


Leu Ala Phe Ile Met Glu Asp Leu Glu Asp Val Ala Leu Asp His Val 
    50                  55                  60                  


Asp Lys Leu Gly Arg Xaa Ala Phe His Arg Ala Ala Glu His Gly Gln 
65                  70                  75                  80  


Leu Asp Ala Leu Asp Phe Leu Val Gly Ser Gly Cys Asp His Asn Val 
                85                  90                  95      


Lys Asp Lys Glu Gly Asn Xaa Ala Leu His Leu Ala Ala Gly Arg Gly 
            100                 105                 110         


His Met Ala Val Leu Gln Arg Leu Val Asp Ile Gly Leu Asp Leu Glu 
        115                 120                 125             


Glu Gln Asn Ala Glu Gly Leu Xaa Ala Leu His Ser Ala Ala Gly Gly 
    130                 135                 140                 


Ser His Pro Asp Cys Val Gln Leu Leu Leu Arg Ala Gly Ser Xaa Val 
145                 150                 155                 160 


Asn Ala Leu Xaa Gln Val Ala Arg Pro Ser Gln Asp Cys Gly Arg Leu 
                165                 170                 175     


Leu Ala Ala Glu Pro 
            180     


<210> 2345
<211> 123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<400> 2345
Met Gln Glu Glu Leu Ala Trp Glu Xaa Asp Gly Leu Leu Pro Leu Glu 
1               5                   10                  15      


Arg Gln Leu His Glu Ala Ala Arg Gln Asn Asn Val Gly Arg Met Gln 
            20                  25                  30          


Glu Leu Ile Gly Arg Arg Val Asn Xaa Arg Ala Arg Asn His Val Gly 
        35                  40                  45              


Arg Val Ala Leu His Trp Ala Ala Gly Ala Gly His Glu Gln Ala Val 
    50                  55                  60                  


Arg Leu Leu Leu Glu His Glu Ala Ala Val Asp Glu Glu Asp Ala Phe 
65                  70                  75                  80  


Gly Met Asn Ala Leu Leu Leu Ser Ala Trp Phe Gly His Leu Arg Ile 
                85                  90                  95      


Leu Gln Ile Leu Val Asn Ser Gly Ala Lys Ile His Cys Glu Ser Lys 
            100                 105                 110         


Pro Lys Lys Ala Met Cys Leu Cys Trp Arg Ser 
        115                 120             


<210> 2346
<211> 522
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<400> 2346
Met Gln Glu Glu Leu Ala Trp Glu Xaa Asp Gly Leu Leu Pro Leu Glu 
1               5                   10                  15      


Arg Gln Leu His Glu Ala Ala Arg Gln Asn Asn Val Gly Arg Met Gln 
            20                  25                  30          


Glu Leu Ile Gly Arg Arg Val Asn Xaa Arg Ala Arg Asn His Val Gly 
        35                  40                  45              


Arg Val Ala Leu His Trp Ala Ala Gly Ala Gly His Glu Gln Ala Val 
    50                  55                  60                  


Arg Leu Leu Leu Glu His Glu Ala Ala Val Asp Glu Glu Asp Ala Val 
65                  70                  75                  80  


Gly Ala Leu Xaa Glu Ala Arg Leu Cys Phe Gly Met Asn Ala Leu Leu 
                85                  90                  95      


Leu Ser Ala Trp Phe Gly His Leu Arg Ile Leu Gln Ile Leu Val Asn 
            100                 105                 110         


Ser Gly Ala Lys Ile His Cys Glu Ser Lys Asp Gly Leu Xaa Leu Leu 
        115                 120                 125             


His Cys Ala Ala Gln Lys Gly His Val Pro Val Leu Ala Phe Ile Met 
    130                 135                 140                 


Glu Asp Leu Glu Asp Val Ala Leu Asp His Val Asp Lys Leu Gly Arg 
145                 150                 155                 160 


Xaa Ala Phe His Arg Ala Ala Glu His Gly Gln Leu Asp Ala Leu Asp 
                165                 170                 175     


Phe Leu Val Gly Ser Gly Cys Asp His Asn Val Lys Asp Lys Glu Gly 
            180                 185                 190         


Asn Xaa Ala Leu His Leu Ala Ala Gly Arg Gly His Met Ala Val Leu 
        195                 200                 205             


Gln Arg Leu Val Asp Ile Gly Leu Asp Leu Glu Glu Gln Asn Ala Glu 
    210                 215                 220                 


Gly Leu Xaa Ala Leu His Ser Ala Ala Gly Gly Ser His Pro Asp Cys 
225                 230                 235                 240 


Val Gln Leu Leu Leu Arg Ala Gly Ser Xaa Val Asn Ala Leu Xaa Gln 
                245                 250                 255     


Lys Asn Leu Ser Cys Leu His Tyr Ala Ala Leu Ser Gly Ser Glu Asp 
            260                 265                 270         


Val Ser Arg Val Leu Ile His Ala Gly Gly Cys Ala Asn Val Val Asp 
        275                 280                 285             


His Gln Gly Ala Ser Pro Leu His Leu Ala Val Arg His Asn Phe Pro 
    290                 295                 300                 


Ala Leu Val Arg Leu Leu Ile Asn Ser Asp Ser Asp Val Asn Ala Val 
305                 310                 315                 320 


Asp Asn Arg Gln Gln Xaa Pro Leu His Leu Ala Ala Glu His Ala Trp 
                325                 330                 335     


Gln Asp Ile Ala Asp Met Leu Leu Ile Ala Gly Val Asp Leu Asn Leu 
            340                 345                 350         


Arg Asp Lys Gln Gly Lys Xaa Ala Leu Ala Val Ala Val Arg Ser Asn 
        355                 360                 365             


His Val Ser Leu Val Asp Met Ile Ile Lys Ala Asp Arg Phe Tyr Arg 
    370                 375                 380                 


Trp Glu Lys Asp His Pro Ser Asp Pro Ser Gly Lys Ser Leu Ser Phe 
385                 390                 395                 400 


Lys Gln Asp His Arg Gln Glu Xaa Gln Gln Leu Arg Ser Val Leu Trp 
                405                 410                 415     


Arg Leu Ala Ser Arg Tyr Leu Gln Pro Arg Glu Trp Lys Lys Leu Ala 
            420                 425                 430         


Tyr Ser Trp Glu Phe Xaa Glu Ala His Val Asp Ala Ile Glu Gln Gln 
        435                 440                 445             


Trp Xaa Gly Xaa Arg Ser Tyr Gln Glu His Gly His Arg Met Leu Leu 
    450                 455                 460                 


Ile Trp Leu His Gly Val Ala Xaa Ala Gly Glu Asn Pro Ser Lys Ala 
465                 470                 475                 480 


Leu Phe Glu Gly Leu Val Ala Ile Gly Arg Arg Asp Leu Ala Gly Trp 
                485                 490                 495     


Ser Xaa Met Ala Arg Ser Gln Leu Xaa Ala Xaa Ser Ala Ser Arg Val 
            500                 505                 510         


Gln Met Ile Leu Val Pro Gln Pro Pro Glu 
        515                 520         


<210> 2347
<211> 528
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<400> 2347
Met Asp Pro Ala Gly Arg Ala Arg Gly Gln Gly Ala Xaa Ala Gly Gly 
1               5                   10                  15      


Leu Leu Leu Arg Ala Ala Ala Ala Ala Lys Gly Leu Arg Glu Asp Leu 
            20                  25                  30          


Trp Gly Ala Ala Ala Leu Pro Trp Arg Ser Leu Ser Arg Ile Pro Lys 
        35                  40                  45              


Arg Glu Gly Leu Gly Glu Glu Asp Xaa Ala Val Ala Gly His Glu Leu 
    50                  55                  60                  


Leu Leu Pro Asn Glu Arg Ser Phe Gln Asn Ala Ala Lys Ser Asn Asn 
65                  70                  75                  80  


Leu Asp Leu Met Glu Lys Leu Phe Glu Lys Lys Val Asn Ile Asn Val 
                85                  90                  95      


Val Asn Asn Met Asn Arg Xaa Ala Leu His Phe Ala Val Gly Arg Asn 
            100                 105                 110         


His Leu Ser Ala Val Asp Phe Leu Leu Lys His Lys Ala Arg Val Asp 
        115                 120                 125             


Val Ala Asp Lys His Gly Leu Xaa Val Ile His Leu Ala Ala Trp Ser 
    130                 135                 140                 


Gly Ser Leu Glu Val Met Leu Met Leu Val Lys Ala Gly Ala Asp Gln 
145                 150                 155                 160 


Arg Ala Lys Asn Gln Asp Gly Met Ser Ala Leu His Phe Ala Xaa Gln 
                165                 170                 175     


Ser Asn His Val Arg Ile Val Glu Tyr Leu Ile Gln Asp Leu His Leu 
            180                 185                 190         


Lys Asp Leu Asn Gln Pro Asp Glu Lys Gly Arg Lys Pro Phe Leu Leu 
        195                 200                 205             


Ala Ala Glu Arg Gly His Val Glu Met Ile Glu Lys Leu Xaa Phe Leu 
    210                 215                 220                 


Asn Leu His Xaa Ser Glu Lys Asp Lys Gly Gly Asn Xaa Ala Leu His 
225                 230                 235                 240 


Leu Ala Ala Lys His Gly His Ser Pro Ala Val Gln Val Leu Leu Ala 
                245                 250                 255     


Gln Trp Gln Asp Ile Asn Glu Met Asn Glu Leu Asn Ile Ser Ser Leu 
            260                 265                 270         


Gln Ile Ala Xaa Arg Asn Gly His Ala Ser Leu Val Asn Phe Leu Leu 
        275                 280                 285             


Ser Glu Asn Val Asp Leu His Gln Lys Val Glu Pro Lys Glu Ser Pro 
    290                 295                 300                 


Leu His Leu Val Val Ile Asn Asn His Ile Xaa Val Val Asn Ser Leu 
305                 310                 315                 320 


Leu Ser Ala Gln His Asp Ile Asp Ile Leu Asn Gln Lys Gln Gln Xaa 
                325                 330                 335     


Pro Leu His Val Ala Ala Asp Arg Gly Asn Val Glu Leu Val Glu Xaa 
            340                 345                 350         


Leu Leu Lys Ala Gly Cys Asp Leu Lys Ala Val Asp Lys Gln Gly Lys 
        355                 360                 365             


Xaa Ala Leu Ala Val Ala Ser Arg Ser Asn His Ser Leu Val Val Gly 
    370                 375                 380                 


Met Leu Ile Lys Ala Glu Arg Tyr Tyr Ala Trp Arg Glu Glu His His 
385                 390                 395                 400 


Glu Ser Ile Arg Asp Pro Ser Xaa Gly Phe Xaa Leu Xaa Phe Lys Gln 
                405                 410                 415     


Asp His Ser Leu Glu Xaa Arg His Ile Arg Xaa Leu Leu Trp Asp Leu 
            420                 425                 430         


Ala Tyr His Gln Leu Lys Ala Asn Glu Trp Gln Arg Leu Ala Arg Ser 
        435                 440                 445             


Trp Asn Phe Xaa Asp Asp Gln Ile Arg Ala Ile Glu Glu Gln Trp Ser 
    450                 455                 460                 


Gly Asn Glu Ser Phe Arg Glu His Gly His Arg Ala Leu Leu Ile Trp 
465                 470                 475                 480 


Leu His Gly Xaa Leu Met Xaa Gln Gly Asp Pro Ala Lys Gln Leu Tyr 
                485                 490                 495     


Glu Glu Leu Val His Ala Gly Phe Pro Lys Leu Ala Glu Lys Xaa Arg 
            500                 505                 510         


His Phe Lys Ser Lys Xaa Asp Ser Asn Ser Lys Lys Cys Val Val Ser 
        515                 520                 525             


<210> 2348
<211> 341
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(322)
<223> Selenocysteine

<400> 2348
Met Val His Ile Lys Lys Gly Glu Leu Xaa Gln Glu Glu Lys Glu Leu 
1               5                   10                  15      


Leu Glu Val Ile Gly Lys Gly Xaa Val Gln Glu Ala Gly Xaa Leu Leu 
            20                  25                  30          


Ser Ser Lys Asn Val Arg Val Asn Cys Leu Asp Glu Asn Gly Met Xaa 
        35                  40                  45              


Pro Leu Met His Ala Ala Tyr Lys Gly Lys Leu Asp Met Cys Lys Leu 
    50                  55                  60                  


Leu Leu Arg His Gly Ala Asp Val Asn Cys His Gln His Glu His Gly 
65                  70                  75                  80  


Tyr Xaa Ala Leu Met Phe Ala Ala Leu Ser Gly Asn Lys Asp Ile Xaa 
                85                  90                  95      


Trp Val Met Leu Glu Ala Gly Ala Glu Xaa Asp Val Val Asn Ser Val 
            100                 105                 110         


Gly Arg Xaa Ala Ala Gln Met Ala Ala Phe Val Gly Gln His Asp Cys 
        115                 120                 125             


Val Xaa Ile Ile Asn Asn Phe Phe Pro Arg Glu Arg Leu Asp Tyr Tyr 
    130                 135                 140                 


Xaa Lys Pro Gln Gly Leu Asp Lys Glu Pro Lys Leu Pro Pro Lys Leu 
145                 150                 155                 160 


Ala Gly Pro Leu His Lys Ile Ile Xaa Xaa Xaa Asn Leu His Pro Val 
                165                 170                 175     


Lys Ile Val Met Leu Val Asn Glu Asn Pro Leu Leu Xaa Glu Glu Ala 
            180                 185                 190         


Ala Leu Asn Lys Cys Tyr Arg Val Met Asp Leu Ile Cys Glu Lys Cys 
        195                 200                 205             


Met Lys Gln Arg Asp Met Asn Glu Val Leu Ala Met Lys Met His Tyr 
    210                 215                 220                 


Ile Ser Cys Ile Phe Gln Lys Cys Ile Asn Phe Leu Lys Asp Gly Glu 
225                 230                 235                 240 


Asn Lys Leu Asp Xaa Leu Ile Lys Ser Leu Leu Lys Gly Arg Ala Ser 
                245                 250                 255     


Asp Gly Phe Pro Val Tyr Gln Glu Lys Ile Ile Arg Glu Ser Ile Arg 
            260                 265                 270         


Lys Phe Pro Tyr Cys Glu Ala Xaa Leu Leu Gln Gln Leu Val Arg Ser 
        275                 280                 285             


Ile Ala Pro Val Glu Ile Gly Ser Asp Pro Xaa Ala Phe Ser Val Leu 
    290                 295                 300                 


Xaa Gln Ala Ile Xaa Gly Gln Val Gly Phe Val Asp Val Glu Phe Cys 
305                 310                 315                 320 


Xaa Xaa Cys Gly Glu Lys Gly Ala Ser Lys Arg Cys Ser Val Cys Lys 
                325                 330                 335     


Met Cys Arg Glu Leu 
            340     


<210> 2349
<211> 441
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<400> 2349
Met Val His Ile Lys Lys Gly Glu Leu Xaa Gln Glu Glu Lys Glu Leu 
1               5                   10                  15      


Leu Glu Val Ile Gly Lys Gly Xaa Val Gln Glu Ala Gly Xaa Leu Leu 
            20                  25                  30          


Ser Ser Lys Asn Val Arg Val Asn Cys Leu Asp Glu Asn Gly Met Xaa 
        35                  40                  45              


Pro Leu Met His Ala Ala Tyr Lys Gly Lys Leu Asp Met Cys Lys Leu 
    50                  55                  60                  


Leu Leu Arg His Gly Ala Asp Val Asn Cys His Gln His Glu His Gly 
65                  70                  75                  80  


Tyr Xaa Ala Leu Met Phe Ala Ala Leu Ser Gly Asn Lys Asp Ile Xaa 
                85                  90                  95      


Trp Val Met Leu Glu Ala Gly Ala Glu Xaa Asp Val Val Asn Ser Val 
            100                 105                 110         


Gly Arg Xaa Ala Ala Gln Met Ala Ala Phe Val Gly Gln His Asp Cys 
        115                 120                 125             


Val Xaa Ile Ile Asn Asn Phe Phe Pro Arg Glu Arg Leu Asp Tyr Tyr 
    130                 135                 140                 


Xaa Lys Pro Gln Gly Leu Asp Lys Glu Pro Lys Leu Pro Pro Lys Leu 
145                 150                 155                 160 


Ala Gly Pro Leu His Lys Ile Ile Xaa Xaa Xaa Asn Leu His Pro Val 
                165                 170                 175     


Lys Ile Val Met Leu Val Asn Glu Asn Pro Leu Leu Xaa Glu Glu Ala 
            180                 185                 190         


Ala Leu Asn Lys Cys Tyr Arg Val Met Asp Leu Ile Cys Glu Lys Cys 
        195                 200                 205             


Met Lys Gln Arg Asp Met Asn Glu Val Leu Ala Met Lys Met His Tyr 
    210                 215                 220                 


Ile Ser Cys Ile Phe Gln Lys Cys Ile Asn Phe Leu Lys Asp Gly Glu 
225                 230                 235                 240 


Asn Lys Leu Asp Xaa Leu Ile Lys Ser Leu Leu Lys Gly Arg Ala Ser 
                245                 250                 255     


Asp Gly Phe Pro Val Tyr Gln Glu Lys Ile Ile Arg Glu Ser Ile Arg 
            260                 265                 270         


Lys Phe Pro Tyr Cys Glu Ala Xaa Leu Leu Gln Gln Leu Val Arg Ser 
        275                 280                 285             


Ile Ala Pro Val Glu Ile Gly Ser Asp Pro Xaa Ala Phe Ser Val Leu 
    290                 295                 300                 


Xaa Gln Ala Ile Xaa Gly Gln Val Gly Phe Val Asp Val Glu Phe Cys 
305                 310                 315                 320 


Xaa Xaa Cys Gly Glu Lys Gly Ala Ser Lys Arg Cys Ser Val Cys Lys 
                325                 330                 335     


Met Val Ile Tyr Cys Asp Gln Xaa Cys Gln Lys Xaa His Trp Phe Xaa 
            340                 345                 350         


His Lys Lys Ile Cys Lys Asn Leu Lys Asp Ile Tyr Glu Lys Gln Gln 
        355                 360                 365             


Leu Glu Ala Ala Lys Glu Lys Arg Gln Glu Glu Asn His Gly Lys Leu 
    370                 375                 380                 


Asp Val Asn Ser Asn Cys Val Asn Glu Glu Gln Pro Glu Ala Glu Val 
385                 390                 395                 400 


Gly Ile Ser Gln Lys Asp Ser Asn Pro Glu Asp Ser Gly Glu Gly Lys 
                405                 410                 415     


Lys Glu Ser Leu Glu Ser Glu Ala Glu Leu Glu Gly Leu Gln Asp Ala 
            420                 425                 430         


Pro Ala Gly Pro Gln Val Ser Glu Glu 
        435                 440     


<210> 2350
<211> 69
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<400> 2350
Met Val His Ile Lys Lys Gly Glu Leu Xaa Gln Glu Glu Lys Glu Leu 
1               5                   10                  15      


Leu Glu Val Ile Gly Lys Gly Val Pro His Phe Arg Ser Ala Glu Ser 
            20                  25                  30          


Gln Arg Gly Ala Pro Arg Xaa Ser Gln Lys Pro Tyr Phe Pro Gly Val 
        35                  40                  45              


Pro Glu Trp Xaa Ser Gln Arg Ser Ser Leu Pro Ser Pro Val Xaa Trp 
    50                  55                  60                  


Gln Val Xaa Ser Ala 
65                  


<210> 2351
<211> 319
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<400> 2351
Met Met Val Leu Lys Val Glu Glu Leu Val Xaa Gly Lys Lys Asn Gly 
1               5                   10                  15      


Asn Gly Glu Ala Gly Glu Phe Leu Pro Glu Asp Phe Arg Asp Gly Glu 
            20                  25                  30          


Tyr Glu Ala Ala Val Xaa Leu Glu Lys Gln Glu Asp Leu Lys Xaa Leu 
        35                  40                  45              


Leu Ala His Pro Val Xaa Leu Gly Glu Gln Gln Trp Lys Ser Glu Lys 
    50                  55                  60                  


Gln Arg Glu Ala Glu Leu Lys Lys Lys Lys Leu Glu Gln Arg Ser Lys 
65                  70                  75                  80  


Leu Glu Asn Leu Glu Asp Leu Glu Ile Ile Ile Gln Leu Lys Lys Arg 
                85                  90                  95      


Lys Lys Tyr Arg Lys Xaa Lys Val Pro Val Val Lys Glu Pro Glu Pro 
            100                 105                 110         


Glu Ile Ile Xaa Glu Pro Val Asp Val Pro Xaa Phe Leu Lys Ala Ala 
        115                 120                 125             


Leu Glu Asn Lys Leu Pro Val Val Glu Lys Phe Leu Ser Asp Lys Asn 
    130                 135                 140                 


Asn Pro Asp Val Cys Asp Glu Tyr Lys Arg Xaa Ala Leu His Arg Ala 
145                 150                 155                 160 


Cys Leu Glu Gly His Leu Ala Ile Val Glu Lys Leu Met Glu Ala Gly 
                165                 170                 175     


Ala Gln Ile Glu Phe Arg Asp Met Leu Glu Ser Xaa Ala Ile His Trp 
            180                 185                 190         


Ala Ser Arg Gly Gly Asn Leu Asp Val Leu Lys Leu Leu Leu Asn Lys 
        195                 200                 205             


Gly Ala Lys Ile Ser Ala Arg Asp Lys Leu Leu Ser Xaa Ala Leu His 
    210                 215                 220                 


Val Ala Val Arg Xaa Gly His Tyr Glu Cys Ala Glu His Leu Ile Ala 
225                 230                 235                 240 


Cys Glu Ala Asp Leu Asn Ala Lys Asp Arg Glu Gly Asp Xaa Pro Leu 
                245                 250                 255     


His Asp Ala Val Arg Leu Asn Arg Tyr Lys Met Ile Arg Leu Leu Ile 
            260                 265                 270         


Met Tyr Gly Ala Asp Leu Asn Ile Lys Asn Cys Ala Gly Lys Xaa Pro 
        275                 280                 285             


Met Asp Leu Val Leu His Trp Gln Asn Gly Xaa Lys Ala Ile Phe Asp 
    290                 295                 300                 


Ser Leu Arg Glu Asn Ser Tyr Lys Xaa Ser Arg Ile Ala Xaa Phe 
305                 310                 315                 


<210> 2352
<211> 420
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<400> 2352
Met Ser Ala Ala Gly Ala Gly Ala Gly Val Glu Ala Gly Phe Ser Ser 
1               5                   10                  15      


Glu Glu Leu Leu Ser Leu Arg Phe Pro Leu His Arg Ala Cys Arg Asp 
            20                  25                  30          


Gly Asp Leu Ala Xaa Leu Cys Ser Leu Leu Gln Gln Xaa Pro His Ala 
        35                  40                  45              


His Leu Ala Ser Glu Asp Ser Phe Tyr Gly Trp Xaa Pro Val His Trp 
    50                  55                  60                  


Ala Ala His Phe Gly Lys Leu Glu Cys Leu Val Gln Leu Val Arg Ala 
65                  70                  75                  80  


Gly Ala Xaa Leu Asn Val Ser Xaa Xaa Arg Tyr Ala Gln Xaa Pro Ala 
                85                  90                  95      


His Ile Ala Ala Phe Gly Gly His Pro Gln Cys Leu Val Trp Leu Ile 
            100                 105                 110         


Gln Ala Gly Ala Asn Ile Asn Lys Pro Asp Cys Glu Gly Glu Xaa Pro 
        115                 120                 125             


Ile His Lys Ala Ala Arg Ser Gly Ser Leu Glu Cys Ile Ser Ala Leu 
    130                 135                 140                 


Val Ala Asn Gly Ala His Val Asp Leu Arg Asn Ala Ser Gly Leu Xaa 
145                 150                 155                 160 


Ala Ala Asp Ile Ala Gln Xaa Gln Gly Phe Gln Glu Cys Ala Gln Phe 
                165                 170                 175     


Leu Leu Asn Leu Gln Asn Cys His Leu Asn His Phe Tyr Asn Asn Gly 
            180                 185                 190         


Ile Leu Asn Gly Gly His Gln Asn Val Phe Pro Asn His Ile Ser Val 
        195                 200                 205             


Gly Xaa Asn Arg Lys Arg Cys Leu Glu Asp Ser Glu Asp Phe Gly Val 
    210                 215                 220                 


Lys Lys Ala Arg Xaa Glu Ala Gln Ser Leu Asp Ser Ala Val Pro Leu 
225                 230                 235                 240 


Xaa Asn Gly Asp Xaa Glu Asp Asp Ala Asp Lys Met His Val Asp Arg 
                245                 250                 255     


Glu Phe Ala Val Val Xaa Asp Met Lys Asn Ser Ser Ser Val Ser Asn 
            260                 265                 270         


Xaa Leu Xaa Asn Gly Cys Val Ile Asn Gly His Leu Asp Phe Pro Ser 
        275                 280                 285             


Xaa Xaa Pro Leu Ser Gly Met Glu Ser Arg Asn Gly Gln Cys Leu Xaa 
    290                 295                 300                 


Gly Xaa Asn Gly Ile Ser Ser Gly Leu Ala Pro Gly Gln Pro Phe Pro 
305                 310                 315                 320 


Ser Ser Gln Gly Ser Leu Cys Ile Ser Gly Xaa Glu Glu Pro Glu Lys 
                325                 330                 335     


Xaa Leu Arg Ala Asn Pro Glu Leu Cys Gly Ser Leu His Leu Asn Gly 
            340                 345                 350         


Ser Pro Ser Ser Cys Ile Ala Ser Arg Pro Ser Trp Val Glu Asp Ile 
        355                 360                 365             


Gly Asp Asn Leu Tyr Tyr Gly His Tyr His Gly Phe Gly Asp Xaa Ala 
    370                 375                 380                 


Glu Ser Ile Pro Glu Leu Asn Ser Val Val Glu His Ser Lys Ser Val 
385                 390                 395                 400 


Lys Val Gln Glu Arg Tyr Asp Ser Ala Val Leu Gly Xaa Met His Leu 
                405                 410                 415     


His His Gly Ser 
            420 


<210> 2353
<211> 161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 2353
Met Ser Ala Ala Gly Ala Gly Ala Gly Val Glu Ala Gly Phe Ser Ser 
1               5                   10                  15      


Glu Glu Leu Leu Ser Leu Arg Phe Pro Leu His Arg Ala Cys Arg Asp 
            20                  25                  30          


Gly Asp Leu Ala Xaa Leu Cys Ser Leu Leu Gln Gln Xaa Pro His Ala 
        35                  40                  45              


His Leu Ala Ser Glu Asp Ser Phe Tyr Gly Trp Xaa Pro Val His Trp 
    50                  55                  60                  


Ala Ala His Phe Gly Lys Leu Glu Cys Leu Val Gln Leu Val Arg Ala 
65                  70                  75                  80  


Gly Ala Xaa Leu Asn Val Ser Xaa Xaa Arg Tyr Ala Gln Xaa Pro Ala 
                85                  90                  95      


His Ile Ala Ala Phe Gly Gly His Pro Gln Cys Leu Val Trp Leu Ile 
            100                 105                 110         


Gln Ala Gly Ala Asn Ile Asn Lys Pro Asp Cys Glu Gly Glu Xaa Pro 
        115                 120                 125             


Ile His Lys Ala Ala Arg Ser Gly Ser Leu Glu Cys Ile Ser Ala Leu 
    130                 135                 140                 


Val Ala Asn Gly Ala His Val Asp Asn Pro Arg Lys Gly Glu His Ser 
145                 150                 155                 160 


Ile 
    


<210> 2354
<211> 220
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<400> 2354
Met Ser Ala Ala Gly Ala Gly Ala Gly Val Glu Ala Gly Phe Ser Ser 
1               5                   10                  15      


Glu Glu Leu Leu Ser Leu Arg Phe Pro Leu His Arg Ala Cys Arg Asp 
            20                  25                  30          


Gly Asp Leu Ala Xaa Leu Cys Ser Leu Leu Gln Gln Xaa Pro His Ala 
        35                  40                  45              


His Leu Ala Ser Glu Asp Ser Phe Tyr Gly Trp Xaa Pro Val His Trp 
    50                  55                  60                  


Ala Ala His Phe Gly Lys Leu Glu Cys Leu Val Gln Leu Val Arg Ala 
65                  70                  75                  80  


Gly Ala Xaa Leu Asn Val Ser Xaa Xaa Arg Tyr Ala Gln Xaa Pro Ala 
                85                  90                  95      


His Ile Ala Ala Phe Gly Gly His Pro Gln Cys Leu Val Trp Leu Ile 
            100                 105                 110         


Gln Ala Gly Ala Asn Ile Asn Lys Pro Asp Cys Glu Gly Glu Xaa Pro 
        115                 120                 125             


Ile His Lys Ala Ala Arg Ser Gly Ser Leu Glu Cys Ile Ser Ala Leu 
    130                 135                 140                 


Val Ala Asn Gly Ala His Val Glu Phe Ile Ser Gln Ser Ser Val His 
145                 150                 155                 160 


Ser Cys Leu Pro Gly Glu Leu Gln His Gly Val Xaa Phe Asp Pro Ser 
                165                 170                 175     


Val Leu Ile Gln Cys Leu Lys Pro Glu Lys Cys Gln Trp Pro Asp Ser 
            180                 185                 190         


Ser Arg His Cys Xaa Asn Pro Gly Phe Pro Arg Val Cys Pro Val Ser 
        195                 200                 205             


Leu Glu Pro Pro Glu Leu Ser Ser Glu Pro Phe Leu 
    210                 215                 220 


<210> 2355
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<400> 2355
Xaa Gly His Gln Asn Val Phe Pro Asn His Ile Ser Val Gly Xaa Asn 
1               5                   10                  15      


Arg Lys Arg Cys Leu Glu Asp Ser Glu Asp Phe Gly Val Lys Lys Ala 
            20                  25                  30          


Arg Xaa Glu Ala Gln Ser Leu Asp Ser Ala Val Pro Leu Xaa Asn Gly 
        35                  40                  45              


Asp Xaa Glu Asp Asp Ala Asp Lys Met His Val Asp Arg Glu Phe Ala 
    50                  55                  60                  


Val Val Xaa Gly Gly Ser Gly Gln Phe Pro Val Ser Cys Asn Asn Asn 
65                  70                  75                  80  


Pro Met Val Glu Asp Xaa Lys Gln Gln Glu Ser Gly Ser Val Gly Pro 
                85                  90                  95      


Lys Glu Ile Glu Ile Tyr Xaa Val Ser Ala Met Gln Xaa Pro Cys Arg 
            100                 105                 110         


Cys Arg Asn Gln Tyr Ala Tyr Tyr Phe 
        115                 120     


<210> 2356
<211> 862
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<400> 2356
Met Glu Lys Ala Xaa Val Pro Val Ala Ala Ala Xaa Ala Ala Glu Gly 
1               5                   10                  15      


Glu Gly Ser Pro Pro Ala Val Ala Ala Val Ala Gly Pro Pro Ala Ala 
            20                  25                  30          


Ala Glu Val Gly Gly Gly Val Gly Gly Ser Ser Arg Ala Arg Ser Ala 
        35                  40                  45              


Ser Ser Pro Arg Gly Met Val Arg Val Cys Asp Leu Leu Leu Lys Lys 
    50                  55                  60                  


Lys Pro Pro Gln Gln Gln His His Lys Ala Lys Arg Asn Arg Xaa Cys 
65                  70                  75                  80  


Arg Pro Pro Ser Ser Ser Glu Ser Ser Ser Asp Ser Asp Asn Ser Gly 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Xaa Ser 
            100                 105                 110         


Ser Asn Asn Ser Glu Glu Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu 
        115                 120                 125             


Pro Asp Lys Pro Pro Ala Asn Val Ala Xaa Xaa Leu Pro Ile Arg Asn 
    130                 135                 140                 


Lys Ala Ala Ser Lys Gln Lys Ser Ser Ser His Leu Pro Ala Asn Ser 
145                 150                 155                 160 


Gln Asp Val Gln Gly Tyr Ile Xaa Asn Gln Ser Pro Glu Ser Ile Val 
                165                 170                 175     


Glu Glu Ala Gln Gly Lys Leu Xaa Glu Leu Glu Gln Arg Ile Lys Glu 
            180                 185                 190         


Ala Ile Glu Lys Asn Ala Gln Leu Gln Ser Leu Glu Leu Ala His Ala 
        195                 200                 205             


Asp Gln Leu Xaa Lys Glu Lys Ile Glu Glu Leu Asn Lys Xaa Arg Glu 
    210                 215                 220                 


Glu Gln Ile Gln Lys Lys Gln Lys Ile Leu Glu Glu Leu Gln Lys Val 
225                 230                 235                 240 


Glu Arg Glu Leu Gln Leu Lys Xaa Gln Gln Gln Leu Lys Lys Gln Tyr 
                245                 250                 255     


Leu Glu Val Lys Ala Gln Arg Ile Gln Leu Gln Gln Gln Gln Gln Gln 
            260                 265                 270         


Ser Cys Gln His Leu Gly Leu Leu Xaa Pro Val Gly Val Gly Glu Gln 
        275                 280                 285             


Leu Ser Glu Gly Asp Tyr Ala Arg Leu Gln Gln Val Asp Pro Val Leu 
    290                 295                 300                 


Leu Lys Asp Glu Pro Gln Gln Xaa Ala Ala Gln Met Gly Phe Ala Pro 
305                 310                 315                 320 


Ile Gln Pro Leu Ala Met Pro Gln Ala Leu Pro Leu Ala Ala Gly Pro 
                325                 330                 335     


Leu Pro Pro Gly Ser Ile Ala Asn Leu Xaa Glu Leu Gln Gly Val Ile 
            340                 345                 350         


Val Gly Gln Pro Val Leu Gly Gln Ala Gln Leu Ala Gly Leu Gly Gln 
        355                 360                 365             


Gly Ile Leu Xaa Glu Xaa Gln Gln Gly Leu Met Val Ala Ser Pro Ala 
    370                 375                 380                 


Gln Xaa Leu Asn Asp Xaa Leu Asp Asp Ile Met Ala Val Ser Gly Arg 
385                 390                 395                 400 


Ala Ser Ala Met Ser Asn Xaa Pro Xaa His Ser Ile Ala Ala Ser Ile 
                405                 410                 415     


Ser Gln Pro Gln Xaa Pro Xaa Pro Ser Pro Ile Ile Ser Pro Ser Ala 
            420                 425                 430         


Met Leu Pro Ile Tyr Pro Ala Ile Asp Ile Asp Ala Gln Xaa Glu Ser 
        435                 440                 445             


Asn His Asp Xaa Ala Leu Xaa Leu Ala Cys Ala Gly Gly His Glu Glu 
    450                 455                 460                 


Leu Val Gln Xaa Leu Leu Glu Arg Gly Ala Ser Ile Glu His Arg Asp 
465                 470                 475                 480 


Lys Lys Gly Phe Xaa Pro Leu Ile Leu Ala Ala Xaa Ala Gly His Val 
                485                 490                 495     


Gly Val Val Glu Ile Leu Leu Asp Asn Gly Ala Asp Ile Glu Ala Gln 
            500                 505                 510         


Ser Glu Arg Xaa Lys Asp Xaa Pro Leu Ser Leu Ala Cys Ser Gly Gly 
        515                 520                 525             


Arg Gln Glu Val Val Glu Leu Leu Leu Ala Arg Gly Ala Asn Lys Glu 
    530                 535                 540                 


His Arg Asn Val Ser Asp Tyr Xaa Pro Leu Ser Leu Ala Ala Ser Gly 
545                 550                 555                 560 


Gly Tyr Val Asn Ile Ile Lys Ile Leu Leu Asn Ala Gly Ala Glu Ile 
                565                 570                 575     


Asn Ser Arg Xaa Gly Ser Lys Leu Gly Ile Ser Pro Leu Met Leu Ala 
            580                 585                 590         


Ala Met Asn Gly His Xaa Ala Ala Val Lys Leu Leu Leu Asp Met Gly 
        595                 600                 605             


Ser Asp Ile Asn Ala Gln Ile Glu Xaa Asn Arg Asn Xaa Ala Leu Xaa 
    610                 615                 620                 


Leu Ala Cys Phe Gln Gly Arg Xaa Glu Val Val Ser Leu Leu Leu Asp 
625                 630                 635                 640 


Arg Lys Ala Asn Val Glu His Arg Ala Lys Xaa Gly Leu Xaa Pro Leu 
                645                 650                 655     


Met Glu Ala Ala Ser Gly Gly Tyr Ala Glu Val Gly Arg Val Leu Leu 
            660                 665                 670         


Asp Lys Gly Ala Asp Val Asn Ala Pro Pro Val Pro Ser Ser Arg Asp 
        675                 680                 685             


Xaa Ala Leu Xaa Ile Ala Ala Asp Lys Gly His Tyr Lys Phe Cys Glu 
    690                 695                 700                 


Leu Leu Ile Gly Arg Gly Ala His Ile Asp Val Arg Asn Lys Lys Gly 
705                 710                 715                 720 


Asn Xaa Pro Leu Trp Leu Ala Ala Asn Gly Gly His Leu Asp Val Val 
                725                 730                 735     


Gln Leu Leu Val Gln Ala Gly Ala Asp Val Asp Ala Ala Asp Asn Arg 
            740                 745                 750         


Lys Ile Xaa Pro Leu Met Ala Ala Phe Arg Lys Gly His Val Lys Val 
        755                 760                 765             


Val Arg Tyr Leu Val Lys Glu Val Asn Gln Phe Pro Ser Asp Ser Glu 
    770                 775                 780                 


Cys Met Arg Tyr Ile Ala Xaa Ile Xaa Asp Lys Glu Met Leu Lys Lys 
785                 790                 795                 800 


Cys His Leu Cys Met Glu Ser Ile Val Gln Ala Lys Asp Arg Gln Ala 
                805                 810                 815     


Ala Glu Ala Asn Lys Asn Ala Ser Ile Leu Leu Glu Glu Leu Asp Leu 
            820                 825                 830         


Glu Lys Leu Arg Glu Glu Ser Arg Arg Leu Ala Leu Ala Ala Lys Arg 
        835                 840                 845             


Glu Lys Arg Lys Glu Lys Arg Arg Lys Lys Lys Glu Glu Gln 
    850                 855                 860         


<210> 2357
<211> 2352
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1071)..(1071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1173)..(1173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1280)..(1280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1296)..(1296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1298)..(1299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1357)..(1357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1393)..(1395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1432)..(1432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1438)..(1438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1440)..(1440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1484)..(1484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1504)..(1504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1517)..(1517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1523)..(1523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1528)..(1528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1531)..(1531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1535)..(1535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1579)..(1579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1587)..(1588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1597)..(1597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1599)..(1599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1602)..(1602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1611)..(1611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1614)..(1614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1648)..(1648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1660)..(1660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1665)..(1665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1672)..(1672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1687)..(1687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1715)..(1715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1719)..(1722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1728)..(1728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1732)..(1732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1734)..(1734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1750)..(1750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1758)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1763)..(1765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1771)..(1771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1774)..(1774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1777)..(1777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1782)..(1782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1836)..(1837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1839)..(1839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1885)..(1885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1891)..(1891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1901)..(1901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1905)..(1905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1911)..(1911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1919)..(1919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1924)..(1924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1934)..(1935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1972)..(1972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1975)..(1975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2005)..(2005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2012)..(2012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2028)..(2028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2051)..(2051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2082)..(2082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2086)..(2086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2128)..(2128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2178)..(2178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2187)..(2187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2189)..(2189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2201)..(2201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2254)..(2254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2258)..(2258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2262)..(2262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2326)..(2326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2333)..(2333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2336)..(2336)
<223> Selenocysteine

<400> 2357
Met Glu Lys Ala Xaa Val Pro Val Ala Ala Ala Xaa Ala Ala Glu Gly 
1               5                   10                  15      


Glu Gly Ser Pro Pro Ala Val Ala Ala Val Ala Gly Pro Pro Ala Ala 
            20                  25                  30          


Ala Glu Val Gly Gly Gly Val Gly Gly Ser Ser Arg Ala Arg Ser Ala 
        35                  40                  45              


Ser Ser Pro Arg Gly Met Val Arg Val Cys Asp Leu Leu Leu Lys Lys 
    50                  55                  60                  


Lys Pro Pro Gln Gln Gln His His Lys Ala Lys Arg Asn Arg Xaa Cys 
65                  70                  75                  80  


Arg Pro Pro Ser Ser Ser Glu Ser Ser Ser Asp Ser Asp Asn Ser Gly 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Xaa Ser 
            100                 105                 110         


Ser Asn Asn Ser Glu Glu Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu 
        115                 120                 125             


Val Ser Glu Val Glu Ser Phe Ile Leu Asp Gln Asp Asp Leu Glu Asn 
    130                 135                 140                 


Pro Met Leu Glu Xaa Ala Ser Lys Leu Leu Leu Ser Gly Xaa Ala Asp 
145                 150                 155                 160 


Gly Ala Asp Leu Arg Xaa Val Asp Pro Glu Xaa Gln Ala Arg Leu Glu 
                165                 170                 175     


Ala Leu Leu Glu Ala Ala Gly Ile Gly Lys Leu Ser Xaa Ala Asp Gly 
            180                 185                 190         


Lys Ala Phe Ala Asp Pro Glu Val Leu Arg Arg Leu Xaa Ser Ser Val 
        195                 200                 205             


Ser Cys Ala Leu Asp Glu Ala Ala Ala Ala Leu Xaa Arg Met Arg Ala 
    210                 215                 220                 


Glu Ser Xaa Ala Asn Ala Gly Gln Ser Asp Asn Arg Ser Leu Ala Glu 
225                 230                 235                 240 


Ala Cys Ser Glu Gly Asp Val Asn Ala Val Arg Lys Leu Leu Ile Glu 
                245                 250                 255     


Gly Arg Ser Val Asn Glu His Xaa Glu Glu Gly Glu Ser Leu Leu Cys 
            260                 265                 270         


Leu Ala Cys Ser Ala Gly Tyr Tyr Glu Leu Ala Gln Val Leu Leu Ala 
        275                 280                 285             


Met His Ala Asn Val Glu Asp Arg Gly Ile Lys Gly Asp Ile Xaa Pro 
    290                 295                 300                 


Leu Met Ala Ala Ala Asn Gly Gly His Val Lys Ile Val Lys Leu Leu 
305                 310                 315                 320 


Leu Ala His Lys Ala Asp Val Asn Ala Gln Ser Ser Xaa Gly Asn Xaa 
                325                 330                 335     


Ala Leu Xaa Tyr Ala Cys Ala Gly Gly Tyr Val Asp Val Val Lys Val 
            340                 345                 350         


Leu Leu Glu Ser Gly Ala Ser Ile Glu Asp His Asn Glu Asn Gly His 
        355                 360                 365             


Xaa Pro Leu Met Glu Ala Gly Ser Ala Gly His Val Glu Val Ala Arg 
    370                 375                 380                 


Leu Leu Leu Glu Asn Gly Ala Gly Ile Asn Xaa His Ser Asn Glu Phe 
385                 390                 395                 400 


Lys Glu Ser Ala Leu Xaa Leu Ala Cys Tyr Lys Gly His Leu Glu Met 
                405                 410                 415     


Val Arg Phe Leu Leu Glu Ala Gly Ala Asp Gln Glu His Lys Xaa Asp 
            420                 425                 430         


Glu Met His Xaa Ala Leu Met Glu Ala Cys Met Asp Gly His Val Glu 
        435                 440                 445             


Val Ala Arg Leu Leu Leu Asp Ser Gly Ala Gln Val Asn Met Pro Ala 
    450                 455                 460                 


Asp Ser Phe Glu Ser Pro Leu Xaa Leu Ala Ala Cys Gly Gly His Val 
465                 470                 475                 480 


Glu Leu Ala Ala Leu Leu Ile Glu Arg Gly Ala Ser Leu Glu Glu Val 
                485                 490                 495     


Asn Asp Glu Gly Tyr Xaa Pro Leu Met Glu Ala Ala Arg Glu Gly His 
            500                 505                 510         


Glu Glu Met Val Ala Leu Leu Leu Gly Gln Gly Ala Asn Ile Asn Ala 
        515                 520                 525             


Gln Xaa Glu Glu Xaa Gln Glu Xaa Ala Leu Xaa Leu Ala Cys Cys Gly 
    530                 535                 540                 


Gly Phe Leu Glu Val Ala Asp Phe Leu Ile Lys Ala Gly Ala Asp Ile 
545                 550                 555                 560 


Glu Leu Gly Cys Ser Xaa Pro Leu Met Glu Ala Ala Gln Glu Gly His 
                565                 570                 575     


Leu Glu Leu Val Lys Tyr Leu Leu Ala Ala Gly Ala Asn Val His Ala 
            580                 585                 590         


Xaa Xaa Ala Xaa Gly Asp Xaa Ala Leu Xaa Tyr Ala Cys Glu Asn Gly 
        595                 600                 605             


His Xaa Asp Val Ala Asp Val Leu Leu Gln Ala Gly Ala Asp Leu Glu 
    610                 615                 620                 


His Glu Ser Glu Gly Gly Arg Xaa Pro Leu Met Lys Ala Ala Arg Ala 
625                 630                 635                 640 


Gly His Val Cys Xaa Val Gln Phe Leu Ile Ser Lys Gly Ala Asn Val 
                645                 650                 655     


Asn Arg Xaa Xaa Ala Asn Asn Asp His Xaa Val Leu Ser Leu Ala Cys 
            660                 665                 670         


Ala Gly Gly His Leu Ala Val Val Glu Leu Leu Leu Ala His Gly Ala 
        675                 680                 685             


Asp Pro Xaa His Arg Leu Lys Asp Gly Ser Xaa Met Leu Ile Glu Ala 
    690                 695                 700                 


Ala Lys Gly Gly His Xaa Ser Val Val Cys Tyr Leu Leu Asp Tyr Pro 
705                 710                 715                 720 


Asn Asn Leu Leu Ser Ala Pro Pro Pro Asp Val Xaa Gln Leu Xaa Pro 
                725                 730                 735     


Pro Ser His Asp Leu Asn Arg Ala Pro Arg Val Pro Val Gln Ala Leu 
            740                 745                 750         


Pro Met Val Val Pro Pro Gln Glu Pro Asp Lys Pro Pro Ala Asn Val 
        755                 760                 765             


Ala Xaa Xaa Leu Pro Ile Arg Asn Lys Ala Val Ser Gly Arg Ala Ser 
    770                 775                 780                 


Ala Met Ser Asn Xaa Pro Xaa His Ser Ile Ala Ala Ser Ile Ser Gln 
785                 790                 795                 800 


Pro Gln Xaa Pro Xaa Pro Ser Pro Ile Ile Ser Pro Ser Ala Met Leu 
                805                 810                 815     


Pro Ile Tyr Pro Ala Ile Asp Ile Asp Ala Gln Xaa Glu Ser Asn His 
            820                 825                 830         


Asp Xaa Ala Leu Xaa Leu Ala Cys Ala Gly Gly His Glu Glu Leu Val 
        835                 840                 845             


Gln Xaa Leu Leu Glu Arg Gly Ala Ser Ile Glu His Arg Asp Lys Lys 
    850                 855                 860                 


Gly Phe Xaa Pro Leu Ile Leu Ala Ala Xaa Ala Gly His Val Gly Val 
865                 870                 875                 880 


Val Glu Ile Leu Leu Asp Asn Gly Ala Asp Ile Glu Ala Gln Ser Glu 
                885                 890                 895     


Arg Xaa Lys Asp Xaa Pro Leu Ser Leu Ala Cys Ser Gly Gly Arg Gln 
            900                 905                 910         


Glu Val Val Glu Leu Leu Leu Ala Arg Gly Ala Asn Lys Glu His Arg 
        915                 920                 925             


Asn Val Ser Asp Tyr Xaa Pro Leu Ser Leu Ala Ala Ser Gly Gly Tyr 
    930                 935                 940                 


Val Asn Ile Ile Lys Ile Leu Leu Asn Ala Gly Ala Glu Ile Asn Ser 
945                 950                 955                 960 


Arg Xaa Gly Ser Lys Leu Gly Ile Ser Pro Leu Met Leu Ala Ala Met 
                965                 970                 975     


Asn Gly His Xaa Ala Ala Val Lys Leu Leu Leu Asp Met Gly Ser Asp 
            980                 985                 990         


Ile Asn Ala Gln Ile Glu Xaa Asn  Arg Asn Xaa Ala Leu  Xaa Leu Ala 
        995                 1000                 1005             


Cys Phe  Gln Gly Arg Xaa Glu  Val Val Ser Leu Leu  Leu Asp Arg 
    1010                 1015                 1020             


Lys Ala  Asn Val Glu His Arg  Ala Lys Xaa Gly Leu  Xaa Pro Leu 
    1025                 1030                 1035             


Met Glu  Ala Ala Ser Gly Gly  Tyr Ala Glu Val Gly  Arg Val Leu 
    1040                 1045                 1050             


Leu Asp  Lys Gly Ala Asp Val  Asn Ala Pro Pro Val  Pro Ser Ser 
    1055                 1060                 1065             


Arg Asp  Xaa Ala Leu Xaa Ile  Ala Ala Asp Lys Gly  His Tyr Lys 
    1070                 1075                 1080             


Phe Cys  Glu Leu Leu Ile Gly  Arg Gly Ala His Ile  Asp Val Arg 
    1085                 1090                 1095             


Asn Lys  Lys Gly Asn Xaa Pro  Leu Trp Leu Ala Ala  Asn Gly Gly 
    1100                 1105                 1110             


His Leu  Asp Val Val Gln Leu  Leu Val Gln Ala Gly  Ala Asp Val 
    1115                 1120                 1125             


Asp Ala  Ala Asp Asn Arg Lys  Ile Xaa Pro Leu Met  Ala Ala Phe 
    1130                 1135                 1140             


Arg Lys  Gly His Val Lys Val  Val Arg Tyr Leu Val  Lys Glu Val 
    1145                 1150                 1155             


Asn Gln  Phe Pro Ser Asp Ser  Glu Cys Met Arg Tyr  Ile Ala Xaa 
    1160                 1165                 1170             


Ile Xaa  Asp Lys Glu Met Leu  Lys Lys Cys His Leu  Cys Met Glu 
    1175                 1180                 1185             


Ser Ile  Val Gln Ala Lys Asp  Arg Gln Ala Ala Glu  Ala Asn Lys 
    1190                 1195                 1200             


Asn Ala  Ser Ile Leu Leu Glu  Glu Leu Asp Leu Glu  Lys Leu Arg 
    1205                 1210                 1215             


Glu Glu  Ser Arg Arg Leu Ala  Leu Ala Ala Lys Arg  Glu Lys Arg 
    1220                 1225                 1230             


Lys Glu  Lys Arg Arg Lys Lys  Lys Glu Glu Gln Arg  Arg Lys Leu 
    1235                 1240                 1245             


Glu Glu  Ile Glu Ala Lys Asn  Lys Glu Asn Phe Glu  Leu Gln Ala 
    1250                 1255                 1260             


Ala Gln  Glu Lys Glu Lys Leu  Lys Val Glu Asp Glu  Pro Glu Val 
    1265                 1270                 1275             


Leu Xaa  Glu Pro Pro Ser Ala  Xaa Xaa Xaa Xaa Xaa  Ile Gly Ile 
    1280                 1285                 1290             


Ser Ala  Xaa Trp Xaa Xaa Leu  Ala Gly Ser His Gly  Lys Arg Asn 
    1295                 1300                 1305             


Asn Xaa  Ile Xaa Xaa Xaa Ser  Ser Lys Arg Lys Asn  Arg Lys Asn 
    1310                 1315                 1320             


Lys Ile  Xaa Pro Glu Asn Val  Gln Ile Ile Phe Asp  Asp Pro Leu 
    1325                 1330                 1335             


Pro Ile  Ser Tyr Ser Gln Pro  Glu Lys Val Asn Gly  Glu Ser Lys 
    1340                 1345                 1350             


Ser Ser  Ser Xaa Ser Glu Ser  Gly Asp Ser Asp Asn  Met Arg Ile 
    1355                 1360                 1365             


Ser Ser  Cys Ser Asp Glu Ser  Ser Asn Ser Asn Ser  Ser Arg Lys 
    1370                 1375                 1380             


Ser Asp  Asn His Ser Pro Ala  Val Val Xaa Xaa Xaa  Val Ser Ser 
    1385                 1390                 1395             


Lys Lys  Gln Pro Ser Val Leu  Val Xaa Phe Pro Lys  Glu Glu Arg 
    1400                 1405                 1410             


Lys Ser  Val Ser Gly Lys Ala  Ser Ile Lys Leu Ser  Glu Xaa Ile 
    1415                 1420                 1425             


Ser Glu  Gly Xaa Ser Asn Ser  Leu Ser Xaa Cys Xaa  Lys Ser Gly 
    1430                 1435                 1440             


Pro Ser  Pro Leu Ser Ser Pro  Asn Gly Lys Leu Xaa  Val Ala Ser 
    1445                 1450                 1455             


Pro Lys  Arg Gly Gln Lys Arg  Glu Glu Gly Trp Lys  Glu Val Val 
    1460                 1465                 1470             


Arg Arg  Ser Lys Lys Val Ser  Val Pro Ser Xaa Val  Ile Ser Arg 
    1475                 1480                 1485             


Val Ile  Gly Arg Gly Gly Cys  Asn Ile Asn Ala Ile  Arg Glu Phe 
    1490                 1495                 1500             


Xaa Gly  Ala His Ile Asp Ile  Asp Lys Gln Lys Asp  Lys Xaa Gly 
    1505                 1510                 1515             


Asp Arg  Ile Ile Xaa Ile Arg  Gly Gly Xaa Glu Ser  Xaa Arg Gln 
    1520                 1525                 1530             


Ala Xaa  Gln Leu Ile Asn Ala  Leu Ile Lys Asp Pro  Asp Lys Glu 
    1535                 1540                 1545             


Ile Asp  Glu Leu Ile Pro Lys  Asn Arg Leu Lys Ser  Ser Ser Ala 
    1550                 1555                 1560             


Asn Ser  Lys Ile Gly Ser Ser  Ala Pro Xaa Xaa Xaa  Ala Ala Asn 
    1565                 1570                 1575             


Xaa Ser  Leu Met Gly Ile Lys  Met Xaa Xaa Val Ala  Leu Ser Ser 
    1580                 1585                 1590             


Xaa Ser  Gln Xaa Ala Xaa Ala  Leu Xaa Val Pro Ala  Ile Ser Ser 
    1595                 1600                 1605             


Ala Ser  Xaa His Lys Xaa Ile  Lys Asn Pro Val Asn  Asn Val Arg 
    1610                 1615                 1620             


Pro Gly  Phe Pro Val Ser Leu  Pro Leu Ala Tyr Pro  Pro Pro Gln 
    1625                 1630                 1635             


Phe Ala  His Ala Leu Leu Ala  Ala Gln Xaa Phe Gln  Gln Ile Arg 
    1640                 1645                 1650             


Pro Pro  Arg Leu Pro Met Xaa  His Phe Gly Gly Xaa  Phe Pro Pro 
    1655                 1660                 1665             


Ala Gln  Ser Xaa Trp Gly Pro  Phe Pro Val Arg Pro  Leu Ser Pro 
    1670                 1675                 1680             


Ala Arg  Ala Xaa Asn Ser Pro  Lys Pro His Met Val  Pro Arg His 
    1685                 1690                 1695             


Ser Asn  Gln Asn Ser Ser Gly  Ser Gln Val Asn Ser  Ala Gly Ser 
    1700                 1705                 1710             


Leu Xaa  Ser Ser Pro Xaa Xaa  Xaa Xaa Ser Ser Ser  Ala Ser Xaa 
    1715                 1720                 1725             


Val Pro  Gly Xaa Ser Xaa Asn  Gly Ser Pro Ser Ser  Pro Ser Val 
    1730                 1735                 1740             


Arg Arg  Gln Leu Phe Val Xaa  Val Val Lys Xaa Ser  Asn Ala Xaa 
    1745                 1750                 1755             


Xaa Xaa  Xaa Val Xaa Xaa Xaa  Ala Ser Asn Asn Asn  Xaa Ala Pro 
    1760                 1765                 1770             


Xaa Asn  Ala Xaa Tyr Pro Met  Pro Xaa Ala Lys Glu  His Tyr Pro 
    1775                 1780                 1785             


Val Ser  Ser Pro Ser Ser Pro  Ser Pro Pro Ala Gln  Pro Gly Gly 
    1790                 1795                 1800             


Val Ser  Arg Asn Ser Pro Leu  Asp Cys Gly Ser Ala  Ser Pro Asn 
    1805                 1810                 1815             


Lys Val  Ala Ser Ser Ser Glu  Gln Glu Ala Gly Ser  Pro Pro Val 
    1820                 1825                 1830             


Val Glu  Xaa Xaa Asn Xaa Arg  Pro Pro Asn Ser Ser  Ser Ser Ser 
    1835                 1840                 1845             


Gly Ser  Ser Ser Ala His Ser  Asn Gln Gln Gln Pro  Pro Gly Ser 
    1850                 1855                 1860             


Val Ser  Gln Glu Pro Arg Pro  Pro Leu Gln Gln Ser  Gln Val Pro 
    1865                 1870                 1875             


Pro Pro  Glu Val Arg Met Xaa  Val Pro Pro Leu Ala  Xaa Ser Ser 
    1880                 1885                 1890             


Ala Pro  Val Ala Val Pro Ser  Xaa Ala Pro Val Xaa  Tyr Pro Met 
    1895                 1900                 1905             


Pro Gln  Xaa Pro Met Gly Cys  Pro Gln Pro Xaa Pro  Lys Met Glu 
    1910                 1915                 1920             


Xaa Pro  Ala Ile Arg Pro Pro  Pro His Gly Xaa Xaa  Ala Pro His 
    1925                 1930                 1935             


Lys Asn  Ser Ala Ser Val Gln  Asn Ser Ser Val Ala  Val Leu Ser 
    1940                 1945                 1950             


Val Asn  His Ile Lys Arg Pro  His Ser Val Pro Ser  Ser Val Gln 
    1955                 1960                 1965             


Leu Pro  Ser Xaa Leu Ser Xaa  Gln Ser Ala Cys Gln  Asn Ser Val 
    1970                 1975                 1980             


His Pro  Ala Asn Lys Pro Ile  Ala Pro Asn Phe Ser  Ala Pro Leu 
    1985                 1990                 1995             


Pro Phe  Gly Pro Phe Ser Xaa  Leu Phe Glu Asn Ser  Pro Xaa Ser 
    2000                 2005                 2010             


Ala His  Ala Phe Trp Gly Gly  Ser Val Val Ser Ser  Gln Ser Xaa 
    2015                 2020                 2025             


Pro Glu  Ser Met Leu Ser Gly  Lys Ser Ser Tyr Leu  Pro Asn Ser 
    2030                 2035                 2040             


Asp Pro  Leu His Gln Ser Asp  Xaa Ser Lys Ala Pro  Gly Phe Arg 
    2045                 2050                 2055             


Pro Pro  Leu Gln Arg Pro Ala  Pro Ser Pro Ser Gly  Ile Val Asn 
    2060                 2065                 2070             


Met Asp  Ser Pro Tyr Gly Ser  Val Xaa Pro Ser Ser  Xaa His Leu 
    2075                 2080                 2085             


Gly Asn  Phe Ala Ser Asn Ile  Ser Gly Gly Gln Met  Tyr Gly Pro 
    2090                 2095                 2100             


Gly Ala  Pro Leu Gly Gly Ala  Pro Ala Ala Ala Asn  Phe Asn Arg 
    2105                 2110                 2115             


Gln His  Phe Ser Pro Leu Ser  Leu Leu Xaa Pro Cys  Ser Ser Ala 
    2120                 2125                 2130             


Ser Asn  Asp Ser Ser Ala Gln  Ser Val Ser Ser Gly  Val Arg Ala 
    2135                 2140                 2145             


Pro Ser  Pro Ala Pro Ser Ser  Val Pro Leu Gly Ser  Glu Lys Pro 
    2150                 2155                 2160             


Ser Asn  Val Ser Gln Asp Arg  Lys Val Pro Val Pro  Ile Gly Xaa 
    2165                 2170                 2175             


Glu Arg  Ser Ala Arg Ile Arg  Gln Xaa Gly Xaa Ser  Ala Pro Ser 
    2180                 2185                 2190             


Val Ile  Gly Ser Asn Leu Ser  Xaa Ser Val Gly His  Ser Gly Ile 
    2195                 2200                 2205             


Trp Ser  Phe Glu Gly Ile Gly  Gly Asn Gln Asp Lys  Val Asp Trp 
    2210                 2215                 2220             


Cys Asn  Pro Gly Met Gly Asn  Pro Met Ile His Arg  Pro Met Ser 
    2225                 2230                 2235             


Asp Pro  Gly Val Phe Ser Gln  His Gln Ala Met Glu  Arg Asp Ser 
    2240                 2245                 2250             


Xaa Gly  Ile Val Xaa Pro Ser  Gly Xaa Phe His Gln  His Val Pro 
    2255                 2260                 2265             


Ala Gly  Tyr Met Asp Phe Pro  Lys Val Gly Gly Met  Pro Phe Ser 
    2270                 2275                 2280             


Val Tyr  Gly Asn Ala Met Ile  Pro Pro Val Ala Pro  Ile Pro Asp 
    2285                 2290                 2295             


Gly Ala  Gly Gly Pro Ile Phe  Asn Gly Pro His Ala  Ala Asp Pro 
    2300                 2305                 2310             


Ser Trp  Asn Ser Leu Ile Lys  Met Val Ser Ser Ser  Xaa Glu Asn 
    2315                 2320                 2325             


Asn Gly  Pro Gln Xaa Val Trp  Xaa Gly Pro Trp Ala  Pro His Met 
    2330                 2335                 2340             


Asn Ser  Val His Met Asn Gln  Leu Gly 
    2345                 2350         


<210> 2358
<211> 2603
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1152)..(1152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1213)..(1213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1287)..(1287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1322)..(1322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1325)..(1325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1355)..(1355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1388)..(1388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1424)..(1424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1426)..(1426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1531)..(1531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1537)..(1541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1549)..(1550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1561)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1563)..(1565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1577)..(1577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1608)..(1608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1644)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1658)..(1658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1678)..(1678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1683)..(1683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1689)..(1689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1691)..(1691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1706)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1735)..(1735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1755)..(1755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1768)..(1768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1774)..(1774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1779)..(1779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1782)..(1782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1786)..(1786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1824)..(1826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1830)..(1830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1838)..(1839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1845)..(1845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1848)..(1848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1850)..(1850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1853)..(1853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1862)..(1862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1865)..(1865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1899)..(1899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1911)..(1911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1916)..(1916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1923)..(1923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1938)..(1938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1966)..(1966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1970)..(1973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1979)..(1979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1983)..(1983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1985)..(1985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2001)..(2001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2005)..(2005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2009)..(2012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2014)..(2016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2022)..(2022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2025)..(2025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2028)..(2028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2033)..(2033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2087)..(2088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2090)..(2090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2136)..(2136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2142)..(2142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2152)..(2152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2156)..(2156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2162)..(2162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2170)..(2170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2175)..(2175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2185)..(2186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2223)..(2223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2226)..(2226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2256)..(2256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2263)..(2263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2279)..(2279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2302)..(2302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2333)..(2333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2337)..(2337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2379)..(2379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2429)..(2429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2438)..(2438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2440)..(2440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2452)..(2452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2505)..(2505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2509)..(2509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2513)..(2513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2577)..(2577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2584)..(2584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2587)..(2587)
<223> Selenocysteine

<400> 2358
Met Glu Lys Ala Xaa Val Pro Val Ala Ala Ala Xaa Ala Ala Glu Gly 
1               5                   10                  15      


Glu Gly Ser Pro Pro Ala Val Ala Ala Val Ala Gly Pro Pro Ala Ala 
            20                  25                  30          


Ala Glu Val Gly Gly Gly Val Gly Gly Ser Ser Arg Ala Arg Ser Ala 
        35                  40                  45              


Ser Ser Pro Arg Gly Met Val Arg Val Cys Asp Leu Leu Leu Lys Lys 
    50                  55                  60                  


Lys Pro Pro Gln Gln Gln His His Lys Ala Lys Arg Asn Arg Xaa Cys 
65                  70                  75                  80  


Arg Pro Pro Ser Ser Ser Glu Ser Ser Ser Asp Ser Asp Asn Ser Gly 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Xaa Ser 
            100                 105                 110         


Ser Asn Asn Ser Glu Glu Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu 
        115                 120                 125             


Val Ser Glu Val Glu Ser Phe Ile Leu Asp Gln Asp Asp Leu Glu Asn 
    130                 135                 140                 


Pro Met Leu Glu Xaa Ala Ser Lys Leu Leu Leu Ser Gly Xaa Ala Asp 
145                 150                 155                 160 


Gly Ala Asp Leu Arg Xaa Val Asp Pro Glu Xaa Gln Ala Arg Leu Glu 
                165                 170                 175     


Ala Leu Leu Glu Ala Ala Gly Ile Gly Lys Leu Ser Xaa Ala Asp Gly 
            180                 185                 190         


Lys Ala Phe Ala Asp Pro Glu Val Leu Arg Arg Leu Xaa Ser Ser Val 
        195                 200                 205             


Ser Cys Ala Leu Asp Glu Ala Ala Ala Ala Leu Xaa Arg Met Arg Ala 
    210                 215                 220                 


Glu Ser Xaa Ala Asn Ala Gly Gln Ser Asp Asn Arg Ser Leu Ala Glu 
225                 230                 235                 240 


Ala Cys Ser Glu Gly Asp Val Asn Ala Val Arg Lys Leu Leu Ile Glu 
                245                 250                 255     


Gly Arg Ser Val Asn Glu His Xaa Glu Glu Gly Glu Ser Leu Leu Cys 
            260                 265                 270         


Leu Ala Cys Ser Ala Gly Tyr Tyr Glu Leu Ala Gln Val Leu Leu Ala 
        275                 280                 285             


Met His Ala Asn Val Glu Asp Arg Gly Ile Lys Gly Asp Ile Xaa Pro 
    290                 295                 300                 


Leu Met Ala Ala Ala Asn Gly Gly His Val Lys Ile Val Lys Leu Leu 
305                 310                 315                 320 


Leu Ala His Lys Ala Asp Val Asn Ala Gln Ser Ser Xaa Gly Asn Xaa 
                325                 330                 335     


Ala Leu Xaa Tyr Ala Cys Ala Gly Gly Tyr Val Asp Val Val Lys Val 
            340                 345                 350         


Leu Leu Glu Ser Gly Ala Ser Ile Glu Asp His Asn Glu Asn Gly His 
        355                 360                 365             


Xaa Pro Leu Met Glu Ala Gly Ser Ala Gly His Val Glu Val Ala Arg 
    370                 375                 380                 


Leu Leu Leu Glu Asn Gly Ala Gly Ile Asn Xaa His Ser Asn Glu Phe 
385                 390                 395                 400 


Lys Glu Ser Ala Leu Xaa Leu Ala Cys Tyr Lys Gly His Leu Glu Met 
                405                 410                 415     


Val Arg Phe Leu Leu Glu Ala Gly Ala Asp Gln Glu His Lys Xaa Asp 
            420                 425                 430         


Glu Met His Xaa Ala Leu Met Glu Ala Cys Met Asp Gly His Val Glu 
        435                 440                 445             


Val Ala Arg Leu Leu Leu Asp Ser Gly Ala Gln Val Asn Met Pro Ala 
    450                 455                 460                 


Asp Ser Phe Glu Ser Pro Leu Xaa Leu Ala Ala Cys Gly Gly His Val 
465                 470                 475                 480 


Glu Leu Ala Ala Leu Leu Ile Glu Arg Gly Ala Ser Leu Glu Glu Val 
                485                 490                 495     


Asn Asp Glu Gly Tyr Xaa Pro Leu Met Glu Ala Ala Arg Glu Gly His 
            500                 505                 510         


Glu Glu Met Val Ala Leu Leu Leu Gly Gln Gly Ala Asn Ile Asn Ala 
        515                 520                 525             


Gln Xaa Glu Glu Xaa Gln Glu Xaa Ala Leu Xaa Leu Ala Cys Cys Gly 
    530                 535                 540                 


Gly Phe Leu Glu Val Ala Asp Phe Leu Ile Lys Ala Gly Ala Asp Ile 
545                 550                 555                 560 


Glu Leu Gly Cys Ser Xaa Pro Leu Met Glu Ala Ala Gln Glu Gly His 
                565                 570                 575     


Leu Glu Leu Val Lys Tyr Leu Leu Ala Ala Gly Ala Asn Val His Ala 
            580                 585                 590         


Xaa Xaa Ala Xaa Gly Asp Xaa Ala Leu Xaa Tyr Ala Cys Glu Asn Gly 
        595                 600                 605             


His Xaa Asp Val Ala Asp Val Leu Leu Gln Ala Gly Ala Asp Leu Glu 
    610                 615                 620                 


His Glu Ser Glu Gly Gly Arg Xaa Pro Leu Met Lys Ala Ala Arg Ala 
625                 630                 635                 640 


Gly His Val Cys Xaa Val Gln Phe Leu Ile Ser Lys Gly Ala Asn Val 
                645                 650                 655     


Asn Arg Xaa Xaa Ala Asn Asn Asp His Xaa Val Leu Ser Leu Ala Cys 
            660                 665                 670         


Ala Gly Gly His Leu Ala Val Val Glu Leu Leu Leu Ala His Gly Ala 
        675                 680                 685             


Asp Pro Xaa His Arg Leu Lys Asp Gly Ser Xaa Met Leu Ile Glu Ala 
    690                 695                 700                 


Ala Lys Gly Gly His Xaa Ser Val Val Cys Tyr Leu Leu Asp Tyr Pro 
705                 710                 715                 720 


Asn Asn Leu Leu Ser Ala Pro Pro Pro Asp Val Xaa Gln Leu Xaa Pro 
                725                 730                 735     


Pro Ser His Asp Leu Asn Arg Ala Pro Arg Val Pro Val Gln Ala Leu 
            740                 745                 750         


Pro Met Val Val Pro Pro Gln Glu Pro Asp Lys Pro Pro Ala Asn Val 
        755                 760                 765             


Ala Xaa Xaa Leu Pro Ile Arg Asn Lys Ala Ala Ser Lys Gln Lys Ser 
    770                 775                 780                 


Ser Ser His Leu Pro Ala Asn Ser Gln Asp Val Gln Gly Tyr Ile Xaa 
785                 790                 795                 800 


Asn Gln Ser Pro Glu Ser Ile Val Glu Glu Ala Gln Gly Lys Leu Xaa 
                805                 810                 815     


Glu Leu Glu Gln Arg Ile Lys Glu Ala Ile Glu Lys Asn Ala Gln Leu 
            820                 825                 830         


Gln Ser Leu Glu Leu Ala His Ala Asp Gln Leu Xaa Lys Glu Lys Ile 
        835                 840                 845             


Glu Glu Leu Asn Lys Xaa Arg Glu Glu Gln Ile Gln Lys Lys Gln Lys 
    850                 855                 860                 


Ile Leu Glu Glu Leu Gln Lys Val Glu Arg Glu Leu Gln Leu Lys Xaa 
865                 870                 875                 880 


Gln Gln Gln Leu Lys Lys Gln Tyr Leu Glu Val Lys Ala Gln Arg Ile 
                885                 890                 895     


Gln Leu Gln Gln Gln Gln Gln Gln Ser Cys Gln His Leu Gly Leu Leu 
            900                 905                 910         


Xaa Pro Val Gly Val Gly Glu Gln Leu Ser Glu Gly Asp Tyr Ala Arg 
        915                 920                 925             


Leu Gln Gln Val Asp Pro Val Leu Leu Lys Asp Glu Pro Gln Gln Xaa 
    930                 935                 940                 


Ala Ala Gln Met Gly Phe Ala Pro Ile Gln Pro Leu Ala Met Pro Gln 
945                 950                 955                 960 


Ala Leu Pro Leu Ala Ala Gly Pro Leu Pro Pro Gly Ser Ile Ala Asn 
                965                 970                 975     


Leu Xaa Glu Leu Gln Gly Val Ile Val Gly Gln Pro Val Leu Gly Gln 
            980                 985                 990         


Ala Gln Leu Ala Gly Leu Gly Gln  Gly Ile Leu Xaa Glu  Xaa Gln Gln 
        995                 1000                 1005             


Gly Leu  Met Val Ala Ser Pro  Ala Gln Xaa Leu Asn  Asp Xaa Leu 
    1010                 1015                 1020             


Asp Asp  Ile Met Ala Ala Val  Ser Gly Arg Ala Ser  Ala Met Ser 
    1025                 1030                 1035             


Asn Xaa  Pro Xaa His Ser Ile  Ala Ala Ser Ile Ser  Gln Pro Gln 
    1040                 1045                 1050             


Xaa Pro  Xaa Pro Ser Pro Ile  Ile Ser Pro Ser Ala  Met Leu Pro 
    1055                 1060                 1065             


Ile Tyr  Pro Ala Ile Asp Ile  Asp Ala Gln Xaa Glu  Ser Asn His 
    1070                 1075                 1080             


Asp Xaa  Ala Leu Xaa Leu Ala  Cys Ala Gly Gly His  Glu Glu Leu 
    1085                 1090                 1095             


Val Gln  Xaa Leu Leu Glu Arg  Gly Ala Ser Ile Glu  His Arg Asp 
    1100                 1105                 1110             


Lys Lys  Gly Phe Xaa Pro Leu  Ile Leu Ala Ala Xaa  Ala Gly His 
    1115                 1120                 1125             


Val Gly  Val Val Glu Ile Leu  Leu Asp Asn Gly Ala  Asp Ile Glu 
    1130                 1135                 1140             


Ala Gln  Ser Glu Arg Xaa Lys  Asp Xaa Pro Leu Ser  Leu Ala Cys 
    1145                 1150                 1155             


Ser Gly  Gly Arg Gln Glu Val  Val Glu Leu Leu Leu  Ala Arg Gly 
    1160                 1165                 1170             


Ala Asn  Lys Glu His Arg Asn  Val Ser Asp Tyr Xaa  Pro Leu Ser 
    1175                 1180                 1185             


Leu Ala  Ala Ser Gly Gly Tyr  Val Asn Ile Ile Lys  Ile Leu Leu 
    1190                 1195                 1200             


Asn Ala  Gly Ala Glu Ile Asn  Ser Arg Xaa Gly Ser  Lys Leu Gly 
    1205                 1210                 1215             


Ile Ser  Pro Leu Met Leu Ala  Ala Met Asn Gly His  Xaa Ala Ala 
    1220                 1225                 1230             


Val Lys  Leu Leu Leu Asp Met  Gly Ser Asp Ile Asn  Ala Gln Ile 
    1235                 1240                 1245             


Glu Xaa  Asn Arg Asn Xaa Ala  Leu Xaa Leu Ala Cys  Phe Gln Gly 
    1250                 1255                 1260             


Arg Xaa  Glu Val Val Ser Leu  Leu Leu Asp Arg Lys  Ala Asn Val 
    1265                 1270                 1275             


Glu His  Arg Ala Lys Xaa Gly  Leu Xaa Pro Leu Met  Glu Ala Ala 
    1280                 1285                 1290             


Ser Gly  Gly Tyr Ala Glu Val  Gly Arg Val Leu Leu  Asp Lys Gly 
    1295                 1300                 1305             


Ala Asp  Val Asn Ala Pro Pro  Val Pro Ser Ser Arg  Asp Xaa Ala 
    1310                 1315                 1320             


Leu Xaa  Ile Ala Ala Asp Lys  Gly His Tyr Lys Phe  Cys Glu Leu 
    1325                 1330                 1335             


Leu Ile  Gly Arg Gly Ala His  Ile Asp Val Arg Asn  Lys Lys Gly 
    1340                 1345                 1350             


Asn Xaa  Pro Leu Trp Leu Ala  Ala Asn Gly Gly His  Leu Asp Val 
    1355                 1360                 1365             


Val Gln  Leu Leu Val Gln Ala  Gly Ala Asp Val Asp  Ala Ala Asp 
    1370                 1375                 1380             


Asn Arg  Lys Ile Xaa Pro Leu  Met Ala Ala Phe Arg  Lys Gly His 
    1385                 1390                 1395             


Val Lys  Val Val Arg Tyr Leu  Val Lys Glu Val Asn  Gln Phe Pro 
    1400                 1405                 1410             


Ser Asp  Ser Glu Cys Met Arg  Tyr Ile Ala Xaa Ile  Xaa Asp Lys 
    1415                 1420                 1425             


Glu Met  Leu Lys Lys Cys His  Leu Cys Met Glu Ser  Ile Val Gln 
    1430                 1435                 1440             


Ala Lys  Asp Arg Gln Ala Ala  Glu Ala Asn Lys Asn  Ala Ser Ile 
    1445                 1450                 1455             


Leu Leu  Glu Glu Leu Asp Leu  Glu Lys Leu Arg Glu  Glu Ser Arg 
    1460                 1465                 1470             


Arg Leu  Ala Leu Ala Ala Lys  Arg Glu Lys Arg Lys  Glu Lys Arg 
    1475                 1480                 1485             


Arg Lys  Lys Lys Glu Glu Gln  Arg Arg Lys Leu Glu  Glu Ile Glu 
    1490                 1495                 1500             


Ala Lys  Asn Lys Glu Asn Phe  Glu Leu Gln Ala Ala  Gln Glu Lys 
    1505                 1510                 1515             


Glu Lys  Leu Lys Val Glu Asp  Glu Pro Glu Val Leu  Xaa Glu Pro 
    1520                 1525                 1530             


Pro Ser  Ala Xaa Xaa Xaa Xaa  Xaa Ile Gly Ile Ser  Ala Xaa Trp 
    1535                 1540                 1545             


Xaa Xaa  Leu Ala Gly Ser His  Gly Lys Arg Asn Asn  Xaa Ile Xaa 
    1550                 1555                 1560             


Xaa Xaa  Ser Ser Lys Arg Lys  Asn Arg Lys Asn Lys  Ile Xaa Pro 
    1565                 1570                 1575             


Glu Asn  Val Gln Ile Ile Phe  Asp Asp Pro Leu Pro  Ile Ser Tyr 
    1580                 1585                 1590             


Ser Gln  Pro Glu Lys Val Asn  Gly Glu Ser Lys Ser  Ser Ser Xaa 
    1595                 1600                 1605             


Ser Glu  Ser Gly Asp Ser Asp  Asn Met Arg Ile Ser  Ser Cys Ser 
    1610                 1615                 1620             


Asp Glu  Ser Ser Asn Ser Asn  Ser Ser Arg Lys Ser  Asp Asn His 
    1625                 1630                 1635             


Ser Pro  Ala Val Val Xaa Xaa  Xaa Val Ser Ser Lys  Lys Gln Pro 
    1640                 1645                 1650             


Ser Val  Leu Val Xaa Phe Pro  Lys Glu Glu Arg Lys  Ser Val Ser 
    1655                 1660                 1665             


Gly Lys  Ala Ser Ile Lys Leu  Ser Glu Xaa Ile Ser  Glu Gly Xaa 
    1670                 1675                 1680             


Ser Asn  Ser Leu Ser Xaa Cys  Xaa Lys Ser Gly Pro  Ser Pro Leu 
    1685                 1690                 1695             


Ser Ser  Pro Asn Gly Lys Leu  Xaa Val Ala Ser Pro  Lys Arg Gly 
    1700                 1705                 1710             


Gln Lys  Arg Glu Glu Gly Trp  Lys Glu Val Val Arg  Arg Ser Lys 
    1715                 1720                 1725             


Lys Val  Ser Val Pro Ser Xaa  Val Ile Ser Arg Val  Ile Gly Arg 
    1730                 1735                 1740             


Gly Gly  Cys Asn Ile Asn Ala  Ile Arg Glu Phe Xaa  Gly Ala His 
    1745                 1750                 1755             


Ile Asp  Ile Asp Lys Gln Lys  Asp Lys Xaa Gly Asp  Arg Ile Ile 
    1760                 1765                 1770             


Xaa Ile  Arg Gly Gly Xaa Glu  Ser Xaa Arg Gln Ala  Xaa Gln Leu 
    1775                 1780                 1785             


Ile Asn  Ala Leu Ile Lys Asp  Pro Asp Lys Glu Ile  Asp Glu Leu 
    1790                 1795                 1800             


Ile Pro  Lys Asn Arg Leu Lys  Ser Ser Ser Ala Asn  Ser Lys Ile 
    1805                 1810                 1815             


Gly Ser  Ser Ala Pro Xaa Xaa  Xaa Ala Ala Asn Xaa  Ser Leu Met 
    1820                 1825                 1830             


Gly Ile  Lys Met Xaa Xaa Val  Ala Leu Ser Ser Xaa  Ser Gln Xaa 
    1835                 1840                 1845             


Ala Xaa  Ala Leu Xaa Val Pro  Ala Ile Ser Ser Ala  Ser Xaa His 
    1850                 1855                 1860             


Lys Xaa  Ile Lys Asn Pro Val  Asn Asn Val Arg Pro  Gly Phe Pro 
    1865                 1870                 1875             


Val Ser  Leu Pro Leu Ala Tyr  Pro Pro Pro Gln Phe  Ala His Ala 
    1880                 1885                 1890             


Leu Leu  Ala Ala Gln Xaa Phe  Gln Gln Ile Arg Pro  Pro Arg Leu 
    1895                 1900                 1905             


Pro Met  Xaa His Phe Gly Gly  Xaa Phe Pro Pro Ala  Gln Ser Xaa 
    1910                 1915                 1920             


Trp Gly  Pro Phe Pro Val Arg  Pro Leu Ser Pro Ala  Arg Ala Xaa 
    1925                 1930                 1935             


Asn Ser  Pro Lys Pro His Met  Val Pro Arg His Ser  Asn Gln Asn 
    1940                 1945                 1950             


Ser Ser  Gly Ser Gln Val Asn  Ser Ala Gly Ser Leu  Xaa Ser Ser 
    1955                 1960                 1965             


Pro Xaa  Xaa Xaa Xaa Ser Ser  Ser Ala Ser Xaa Val  Pro Gly Xaa 
    1970                 1975                 1980             


Ser Xaa  Asn Gly Ser Pro Ser  Ser Pro Ser Val Arg  Arg Gln Leu 
    1985                 1990                 1995             


Phe Val  Xaa Val Val Lys Xaa  Ser Asn Ala Xaa Xaa  Xaa Xaa Val 
    2000                 2005                 2010             


Xaa Xaa  Xaa Ala Ser Asn Asn  Asn Xaa Ala Pro Xaa  Asn Ala Xaa 
    2015                 2020                 2025             


Tyr Pro  Met Pro Xaa Ala Lys  Glu His Tyr Pro Val  Ser Ser Pro 
    2030                 2035                 2040             


Ser Ser  Pro Ser Pro Pro Ala  Gln Pro Gly Gly Val  Ser Arg Asn 
    2045                 2050                 2055             


Ser Pro  Leu Asp Cys Gly Ser  Ala Ser Pro Asn Lys  Val Ala Ser 
    2060                 2065                 2070             


Ser Ser  Glu Gln Glu Ala Gly  Ser Pro Pro Val Val  Glu Xaa Xaa 
    2075                 2080                 2085             


Asn Xaa  Arg Pro Pro Asn Ser  Ser Ser Ser Ser Gly  Ser Ser Ser 
    2090                 2095                 2100             


Ala His  Ser Asn Gln Gln Gln  Pro Pro Gly Ser Val  Ser Gln Glu 
    2105                 2110                 2115             


Pro Arg  Pro Pro Leu Gln Gln  Ser Gln Val Pro Pro  Pro Glu Val 
    2120                 2125                 2130             


Arg Met  Xaa Val Pro Pro Leu  Ala Xaa Ser Ser Ala  Pro Val Ala 
    2135                 2140                 2145             


Val Pro  Ser Xaa Ala Pro Val  Xaa Tyr Pro Met Pro  Gln Xaa Pro 
    2150                 2155                 2160             


Met Gly  Cys Pro Gln Pro Xaa  Pro Lys Met Glu Xaa  Pro Ala Ile 
    2165                 2170                 2175             


Arg Pro  Pro Pro His Gly Xaa  Xaa Ala Pro His Lys  Asn Ser Ala 
    2180                 2185                 2190             


Ser Val  Gln Asn Ser Ser Val  Ala Val Leu Ser Val  Asn His Ile 
    2195                 2200                 2205             


Lys Arg  Pro His Ser Val Pro  Ser Ser Val Gln Leu  Pro Ser Xaa 
    2210                 2215                 2220             


Leu Ser  Xaa Gln Ser Ala Cys  Gln Asn Ser Val His  Pro Ala Asn 
    2225                 2230                 2235             


Lys Pro  Ile Ala Pro Asn Phe  Ser Ala Pro Leu Pro  Phe Gly Pro 
    2240                 2245                 2250             


Phe Ser  Xaa Leu Phe Glu Asn  Ser Pro Xaa Ser Ala  His Ala Phe 
    2255                 2260                 2265             


Trp Gly  Gly Ser Val Val Ser  Ser Gln Ser Xaa Pro  Glu Ser Met 
    2270                 2275                 2280             


Leu Ser  Gly Lys Ser Ser Tyr  Leu Pro Asn Ser Asp  Pro Leu His 
    2285                 2290                 2295             


Gln Ser  Asp Xaa Ser Lys Ala  Pro Gly Phe Arg Pro  Pro Leu Gln 
    2300                 2305                 2310             


Arg Pro  Ala Pro Ser Pro Ser  Gly Ile Val Asn Met  Asp Ser Pro 
    2315                 2320                 2325             


Tyr Gly  Ser Val Xaa Pro Ser  Ser Xaa His Leu Gly  Asn Phe Ala 
    2330                 2335                 2340             


Ser Asn  Ile Ser Gly Gly Gln  Met Tyr Gly Pro Gly  Ala Pro Leu 
    2345                 2350                 2355             


Gly Gly  Ala Pro Ala Ala Ala  Asn Phe Asn Arg Gln  His Phe Ser 
    2360                 2365                 2370             


Pro Leu  Ser Leu Leu Xaa Pro  Cys Ser Ser Ala Ser  Asn Asp Ser 
    2375                 2380                 2385             


Ser Ala  Gln Ser Val Ser Ser  Gly Val Arg Ala Pro  Ser Pro Ala 
    2390                 2395                 2400             


Pro Ser  Ser Val Pro Leu Gly  Ser Glu Lys Pro Ser  Asn Val Ser 
    2405                 2410                 2415             


Gln Asp  Arg Lys Val Pro Val  Pro Ile Gly Xaa Glu  Arg Ser Ala 
    2420                 2425                 2430             


Arg Ile  Arg Gln Xaa Gly Xaa  Ser Ala Pro Ser Val  Ile Gly Ser 
    2435                 2440                 2445             


Asn Leu  Ser Xaa Ser Val Gly  His Ser Gly Ile Trp  Ser Phe Glu 
    2450                 2455                 2460             


Gly Ile  Gly Gly Asn Gln Asp  Lys Val Asp Trp Cys  Asn Pro Gly 
    2465                 2470                 2475             


Met Gly  Asn Pro Met Ile His  Arg Pro Met Ser Asp  Pro Gly Val 
    2480                 2485                 2490             


Phe Ser  Gln His Gln Ala Met  Glu Arg Asp Ser Xaa  Gly Ile Val 
    2495                 2500                 2505             


Xaa Pro  Ser Gly Xaa Phe His  Gln His Val Pro Ala  Gly Tyr Met 
    2510                 2515                 2520             


Asp Phe  Pro Lys Val Gly Gly  Met Pro Phe Ser Val  Tyr Gly Asn 
    2525                 2530                 2535             


Ala Met  Ile Pro Pro Val Ala  Pro Ile Pro Asp Gly  Ala Gly Gly 
    2540                 2545                 2550             


Pro Ile  Phe Asn Gly Pro His  Ala Ala Asp Pro Ser  Trp Asn Ser 
    2555                 2560                 2565             


Leu Ile  Lys Met Val Ser Ser  Ser Xaa Glu Asn Asn  Gly Pro Gln 
    2570                 2575                 2580             


Xaa Val  Trp Xaa Gly Pro Trp  Ala Pro His Met Asn  Ser Val His 
    2585                 2590                 2595             


Met Asn  Gln Leu Gly 
    2600             


<210> 2359
<211> 2490
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1152)..(1152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1313)..(1313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1418)..(1418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1424)..(1428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1436)..(1437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1448)..(1448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1464)..(1464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1495)..(1495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1531)..(1533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1565)..(1565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1570)..(1570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1576)..(1576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1578)..(1578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1593)..(1593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1622)..(1622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1642)..(1642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1655)..(1655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1661)..(1661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1666)..(1666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1669)..(1669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1673)..(1673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1711)..(1713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1717)..(1717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1725)..(1726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1732)..(1732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1735)..(1735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1737)..(1737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1749)..(1749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1752)..(1752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1786)..(1786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1798)..(1798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1803)..(1803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1810)..(1810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1825)..(1825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1853)..(1853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1857)..(1860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1866)..(1866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1870)..(1870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1872)..(1872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1888)..(1888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1892)..(1892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1896)..(1899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1901)..(1903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1909)..(1909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1912)..(1912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1915)..(1915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1920)..(1920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1974)..(1975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1977)..(1977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2023)..(2023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2029)..(2029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2039)..(2039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2043)..(2043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2049)..(2049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2057)..(2057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2062)..(2062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2072)..(2073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2110)..(2110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2113)..(2113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2143)..(2143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2150)..(2150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2166)..(2166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2189)..(2189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2220)..(2220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2224)..(2224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2266)..(2266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2316)..(2316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2325)..(2325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2327)..(2327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2339)..(2339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2392)..(2392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2396)..(2396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2400)..(2400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2464)..(2464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2471)..(2471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2474)..(2474)
<223> Selenocysteine

<400> 2359
Met Val Glu Xaa Ala Ala Glu Met Glu Ala Tyr Val Leu Glu Asp Ile 
1               5                   10                  15      


Leu Glu Val Glu Ser Phe Ile Leu Asp Gln Asp Asp Leu Glu Asn Pro 
            20                  25                  30          


Met Leu Glu Xaa Ala Ser Lys Leu Leu Leu Ser Gly Xaa Ala Asp Gly 
        35                  40                  45              


Ala Asp Leu Arg Xaa Val Asp Pro Glu Xaa Gln Ala Arg Leu Glu Ala 
    50                  55                  60                  


Leu Leu Glu Ala Ala Gly Ile Gly Lys Leu Ser Xaa Ala Asp Gly Lys 
65                  70                  75                  80  


Ala Phe Ala Asp Pro Glu Val Leu Arg Arg Leu Xaa Ser Ser Val Ser 
                85                  90                  95      


Cys Ala Leu Asp Glu Ala Ala Ala Ala Leu Xaa Arg Met Arg Ala Glu 
            100                 105                 110         


Ser Xaa Ala Asn Ala Gly Gln Ser Asp Asn Arg Ser Leu Ala Glu Ala 
        115                 120                 125             


Cys Ser Glu Gly Asp Val Asn Ala Val Arg Lys Leu Leu Ile Glu Gly 
    130                 135                 140                 


Arg Ser Val Asn Glu His Xaa Glu Glu Gly Glu Ser Leu Leu Cys Leu 
145                 150                 155                 160 


Ala Cys Ser Ala Gly Tyr Tyr Glu Leu Ala Gln Val Leu Leu Ala Met 
                165                 170                 175     


His Ala Asn Val Glu Asp Arg Gly Ile Lys Gly Asp Ile Xaa Pro Leu 
            180                 185                 190         


Met Ala Ala Ala Asn Gly Gly His Val Lys Ile Val Lys Leu Leu Leu 
        195                 200                 205             


Ala His Lys Ala Asp Val Asn Ala Gln Ser Ser Xaa Gly Asn Xaa Ala 
    210                 215                 220                 


Leu Xaa Tyr Ala Cys Ala Gly Gly Tyr Val Asp Val Val Lys Val Leu 
225                 230                 235                 240 


Leu Glu Ser Gly Ala Ser Ile Glu Asp His Asn Glu Asn Gly His Xaa 
                245                 250                 255     


Pro Leu Met Glu Ala Gly Ser Ala Gly His Val Glu Val Ala Arg Leu 
            260                 265                 270         


Leu Leu Glu Asn Gly Ala Gly Ile Asn Xaa His Ser Asn Glu Phe Lys 
        275                 280                 285             


Glu Ser Ala Leu Xaa Leu Ala Cys Tyr Lys Gly His Leu Glu Met Val 
    290                 295                 300                 


Arg Phe Leu Leu Glu Ala Gly Ala Asp Gln Glu His Lys Xaa Asp Glu 
305                 310                 315                 320 


Met His Xaa Ala Leu Met Glu Ala Cys Met Asp Gly His Val Glu Val 
                325                 330                 335     


Ala Arg Leu Leu Leu Asp Ser Gly Ala Gln Val Asn Met Pro Ala Asp 
            340                 345                 350         


Ser Phe Glu Ser Pro Leu Xaa Leu Ala Ala Cys Gly Gly His Val Glu 
        355                 360                 365             


Leu Ala Ala Leu Leu Ile Glu Arg Gly Ala Ser Leu Glu Glu Val Asn 
    370                 375                 380                 


Asp Glu Gly Tyr Xaa Pro Leu Met Glu Ala Ala Arg Glu Gly His Glu 
385                 390                 395                 400 


Glu Met Val Ala Leu Leu Leu Gly Gln Gly Ala Asn Ile Asn Ala Gln 
                405                 410                 415     


Xaa Glu Glu Xaa Gln Glu Xaa Ala Leu Xaa Leu Ala Cys Cys Gly Gly 
            420                 425                 430         


Phe Leu Glu Val Ala Asp Phe Leu Ile Lys Ala Gly Ala Asp Ile Glu 
        435                 440                 445             


Leu Gly Cys Ser Xaa Pro Leu Met Glu Ala Ala Gln Glu Gly His Leu 
    450                 455                 460                 


Glu Leu Val Lys Tyr Leu Leu Ala Ala Gly Ala Asn Val His Ala Xaa 
465                 470                 475                 480 


Xaa Ala Xaa Gly Asp Xaa Ala Leu Xaa Tyr Ala Cys Glu Asn Gly His 
                485                 490                 495     


Xaa Asp Val Ala Asp Val Leu Leu Gln Ala Gly Ala Asp Leu Glu His 
            500                 505                 510         


Glu Ser Glu Gly Gly Arg Xaa Pro Leu Met Lys Ala Ala Arg Ala Gly 
        515                 520                 525             


His Val Cys Xaa Val Gln Phe Leu Ile Ser Lys Gly Ala Asn Val Asn 
    530                 535                 540                 


Arg Xaa Xaa Ala Asn Asn Asp His Xaa Val Leu Ser Leu Ala Cys Ala 
545                 550                 555                 560 


Gly Gly His Leu Ala Val Val Glu Leu Leu Leu Ala His Gly Ala Asp 
                565                 570                 575     


Pro Xaa His Arg Leu Lys Asp Gly Ser Xaa Met Leu Ile Glu Ala Ala 
            580                 585                 590         


Lys Gly Gly His Xaa Ser Val Val Cys Tyr Leu Leu Asp Tyr Pro Asn 
        595                 600                 605             


Asn Leu Leu Ser Ala Pro Pro Pro Asp Val Xaa Gln Leu Xaa Pro Pro 
    610                 615                 620                 


Ser His Asp Leu Asn Arg Ala Pro Arg Val Pro Val Gln Ala Leu Pro 
625                 630                 635                 640 


Met Val Val Pro Pro Gln Glu Pro Asp Lys Pro Pro Ala Asn Val Ala 
                645                 650                 655     


Xaa Xaa Leu Pro Ile Arg Asn Lys Ala Ala Ser Lys Gln Lys Ser Ser 
            660                 665                 670         


Ser His Leu Pro Ala Asn Ser Gln Asp Val Gln Gly Tyr Ile Xaa Asn 
        675                 680                 685             


Gln Ser Pro Glu Ser Ile Val Glu Glu Ala Gln Gly Lys Leu Xaa Glu 
    690                 695                 700                 


Leu Glu Gln Arg Ile Lys Glu Ala Ile Glu Lys Asn Ala Gln Leu Gln 
705                 710                 715                 720 


Ser Leu Glu Leu Ala His Ala Asp Gln Leu Xaa Lys Glu Lys Ile Glu 
                725                 730                 735     


Glu Leu Asn Lys Xaa Arg Glu Glu Gln Ile Gln Lys Lys Gln Lys Ile 
            740                 745                 750         


Leu Glu Glu Leu Gln Lys Val Glu Arg Glu Leu Gln Leu Lys Xaa Gln 
        755                 760                 765             


Gln Gln Leu Lys Lys Gln Tyr Leu Glu Val Lys Ala Gln Arg Ile Gln 
    770                 775                 780                 


Leu Gln Gln Gln Gln Gln Gln Ser Cys Gln His Leu Gly Leu Leu Xaa 
785                 790                 795                 800 


Pro Val Gly Val Gly Glu Gln Leu Ser Glu Gly Asp Tyr Ala Arg Leu 
                805                 810                 815     


Gln Gln Val Asp Pro Val Leu Leu Lys Asp Glu Pro Gln Gln Xaa Ala 
            820                 825                 830         


Ala Gln Met Gly Phe Ala Pro Ile Gln Pro Leu Ala Met Pro Gln Ala 
        835                 840                 845             


Leu Pro Leu Ala Ala Gly Pro Leu Pro Pro Gly Ser Ile Ala Asn Leu 
    850                 855                 860                 


Xaa Glu Leu Gln Gly Val Ile Val Gly Gln Pro Val Leu Gly Gln Ala 
865                 870                 875                 880 


Gln Leu Ala Gly Leu Gly Gln Gly Ile Leu Xaa Glu Xaa Gln Gln Gly 
                885                 890                 895     


Leu Met Val Ala Ser Pro Ala Gln Xaa Leu Asn Asp Xaa Leu Asp Asp 
            900                 905                 910         


Ile Met Ala Ala Val Ser Gly Arg Ala Ser Ala Met Ser Asn Xaa Pro 
        915                 920                 925             


Xaa His Ser Ile Ala Ala Ser Ile Ser Gln Pro Gln Xaa Pro Xaa Pro 
    930                 935                 940                 


Ser Pro Ile Ile Ser Pro Ser Ala Met Leu Pro Ile Tyr Pro Ala Ile 
945                 950                 955                 960 


Asp Ile Asp Ala Gln Xaa Glu Ser Asn His Asp Xaa Ala Leu Xaa Leu 
                965                 970                 975     


Ala Cys Ala Gly Gly His Glu Glu Leu Val Gln Xaa Leu Leu Glu Arg 
            980                 985                 990         


Gly Ala Ser Ile Glu His Arg Asp  Lys Lys Gly Phe Xaa  Pro Leu Ile 
        995                 1000                 1005             


Leu Ala  Ala Xaa Ala Gly His  Val Gly Val Val Glu  Ile Leu Leu 
    1010                 1015                 1020             


Asp Asn  Gly Ala Asp Ile Glu  Ala Gln Ser Glu Arg  Xaa Lys Asp 
    1025                 1030                 1035             


Xaa Pro  Leu Ser Leu Ala Cys  Ser Gly Gly Arg Gln  Glu Val Val 
    1040                 1045                 1050             


Glu Leu  Leu Leu Ala Arg Gly  Ala Asn Lys Glu His  Arg Asn Val 
    1055                 1060                 1065             


Ser Asp  Tyr Xaa Pro Leu Ser  Leu Ala Ala Ser Gly  Gly Tyr Val 
    1070                 1075                 1080             


Asn Ile  Ile Lys Ile Leu Leu  Asn Ala Gly Ala Glu  Ile Asn Ser 
    1085                 1090                 1095             


Arg Xaa  Gly Ser Lys Leu Gly  Ile Ser Pro Leu Met  Leu Ala Ala 
    1100                 1105                 1110             


Met Asn  Gly His Xaa Ala Ala  Val Lys Leu Leu Leu  Asp Met Gly 
    1115                 1120                 1125             


Ser Asp  Ile Asn Ala Gln Ile  Glu Xaa Asn Arg Asn  Xaa Ala Leu 
    1130                 1135                 1140             


Xaa Leu  Ala Cys Phe Gln Gly  Arg Xaa Glu Val Val  Ser Leu Leu 
    1145                 1150                 1155             


Leu Asp  Arg Lys Ala Asn Val  Glu His Arg Ala Lys  Xaa Gly Leu 
    1160                 1165                 1170             


Xaa Pro  Leu Met Glu Ala Ala  Ser Gly Gly Tyr Ala  Glu Val Gly 
    1175                 1180                 1185             


Arg Val  Leu Leu Asp Lys Gly  Ala Asp Val Asn Ala  Pro Pro Val 
    1190                 1195                 1200             


Pro Ser  Ser Arg Asp Xaa Ala  Leu Xaa Ile Ala Ala  Asp Lys Gly 
    1205                 1210                 1215             


His Tyr  Lys Phe Cys Glu Leu  Leu Ile Gly Arg Gly  Ala His Ile 
    1220                 1225                 1230             


Asp Val  Arg Asn Lys Lys Gly  Asn Xaa Pro Leu Trp  Leu Ala Ala 
    1235                 1240                 1245             


Asn Gly  Gly His Leu Asp Val  Val Gln Leu Leu Val  Gln Ala Gly 
    1250                 1255                 1260             


Ala Asp  Val Asp Ala Ala Asp  Asn Arg Lys Ile Xaa  Pro Leu Met 
    1265                 1270                 1275             


Ala Ala  Phe Arg Lys Gly His  Val Lys Val Val Arg  Tyr Leu Val 
    1280                 1285                 1290             


Lys Glu  Val Asn Gln Phe Pro  Ser Asp Ser Glu Cys  Met Arg Tyr 
    1295                 1300                 1305             


Ile Ala  Xaa Ile Xaa Asp Lys  Glu Met Leu Lys Lys  Cys His Leu 
    1310                 1315                 1320             


Cys Met  Glu Ser Ile Val Gln  Ala Lys Asp Arg Gln  Ala Ala Glu 
    1325                 1330                 1335             


Ala Asn  Lys Asn Ala Ser Ile  Leu Leu Glu Glu Leu  Asp Leu Glu 
    1340                 1345                 1350             


Lys Leu  Arg Glu Glu Ser Arg  Arg Leu Ala Leu Ala  Ala Lys Arg 
    1355                 1360                 1365             


Glu Lys  Arg Lys Glu Lys Arg  Arg Lys Lys Lys Glu  Glu Gln Arg 
    1370                 1375                 1380             


Arg Lys  Leu Glu Glu Ile Glu  Ala Lys Asn Lys Glu  Asn Phe Glu 
    1385                 1390                 1395             


Leu Gln  Ala Ala Gln Glu Lys  Glu Lys Leu Lys Val  Glu Asp Glu 
    1400                 1405                 1410             


Pro Glu  Val Leu Xaa Glu Pro  Pro Ser Ala Xaa Xaa  Xaa Xaa Xaa 
    1415                 1420                 1425             


Ile Gly  Ile Ser Ala Xaa Trp  Xaa Xaa Leu Ala Gly  Ser His Gly 
    1430                 1435                 1440             


Lys Arg  Asn Asn Xaa Ile Xaa  Xaa Xaa Ser Ser Lys  Arg Lys Asn 
    1445                 1450                 1455             


Arg Lys  Asn Lys Ile Xaa Pro  Glu Asn Val Gln Ile  Ile Phe Asp 
    1460                 1465                 1470             


Asp Pro  Leu Pro Ile Ser Tyr  Ser Gln Pro Glu Lys  Val Asn Gly 
    1475                 1480                 1485             


Glu Ser  Lys Ser Ser Ser Xaa  Ser Glu Ser Gly Asp  Ser Asp Asn 
    1490                 1495                 1500             


Met Arg  Ile Ser Ser Cys Ser  Asp Glu Ser Ser Asn  Ser Asn Ser 
    1505                 1510                 1515             


Ser Arg  Lys Ser Asp Asn His  Ser Pro Ala Val Val  Xaa Xaa Xaa 
    1520                 1525                 1530             


Val Ser  Ser Lys Lys Gln Pro  Ser Val Leu Val Xaa  Phe Pro Lys 
    1535                 1540                 1545             


Glu Glu  Arg Lys Ser Val Ser  Gly Lys Ala Ser Ile  Lys Leu Ser 
    1550                 1555                 1560             


Glu Xaa  Ile Ser Glu Gly Xaa  Ser Asn Ser Leu Ser  Xaa Cys Xaa 
    1565                 1570                 1575             


Lys Ser  Gly Pro Ser Pro Leu  Ser Ser Pro Asn Gly  Lys Leu Xaa 
    1580                 1585                 1590             


Val Ala  Ser Pro Lys Arg Gly  Gln Lys Arg Glu Glu  Gly Trp Lys 
    1595                 1600                 1605             


Glu Val  Val Arg Arg Ser Lys  Lys Val Ser Val Pro  Ser Xaa Val 
    1610                 1615                 1620             


Ile Ser  Arg Val Ile Gly Arg  Gly Gly Cys Asn Ile  Asn Ala Ile 
    1625                 1630                 1635             


Arg Glu  Phe Xaa Gly Ala His  Ile Asp Ile Asp Lys  Gln Lys Asp 
    1640                 1645                 1650             


Lys Xaa  Gly Asp Arg Ile Ile  Xaa Ile Arg Gly Gly  Xaa Glu Ser 
    1655                 1660                 1665             


Xaa Arg  Gln Ala Xaa Gln Leu  Ile Asn Ala Leu Ile  Lys Asp Pro 
    1670                 1675                 1680             


Asp Lys  Glu Ile Asp Glu Leu  Ile Pro Lys Asn Arg  Leu Lys Ser 
    1685                 1690                 1695             


Ser Ser  Ala Asn Ser Lys Ile  Gly Ser Ser Ala Pro  Xaa Xaa Xaa 
    1700                 1705                 1710             


Ala Ala  Asn Xaa Ser Leu Met  Gly Ile Lys Met Xaa  Xaa Val Ala 
    1715                 1720                 1725             


Leu Ser  Ser Xaa Ser Gln Xaa  Ala Xaa Ala Leu Xaa  Val Pro Ala 
    1730                 1735                 1740             


Ile Ser  Ser Ala Ser Xaa His  Lys Xaa Ile Lys Asn  Pro Val Asn 
    1745                 1750                 1755             


Asn Val  Arg Pro Gly Phe Pro  Val Ser Leu Pro Leu  Ala Tyr Pro 
    1760                 1765                 1770             


Pro Pro  Gln Phe Ala His Ala  Leu Leu Ala Ala Gln  Xaa Phe Gln 
    1775                 1780                 1785             


Gln Ile  Arg Pro Pro Arg Leu  Pro Met Xaa His Phe  Gly Gly Xaa 
    1790                 1795                 1800             


Phe Pro  Pro Ala Gln Ser Xaa  Trp Gly Pro Phe Pro  Val Arg Pro 
    1805                 1810                 1815             


Leu Ser  Pro Ala Arg Ala Xaa  Asn Ser Pro Lys Pro  His Met Val 
    1820                 1825                 1830             


Pro Arg  His Ser Asn Gln Asn  Ser Ser Gly Ser Gln  Val Asn Ser 
    1835                 1840                 1845             


Ala Gly  Ser Leu Xaa Ser Ser  Pro Xaa Xaa Xaa Xaa  Ser Ser Ser 
    1850                 1855                 1860             


Ala Ser  Xaa Val Pro Gly Xaa  Ser Xaa Asn Gly Ser  Pro Ser Ser 
    1865                 1870                 1875             


Pro Ser  Val Arg Arg Gln Leu  Phe Val Xaa Val Val  Lys Xaa Ser 
    1880                 1885                 1890             


Asn Ala  Xaa Xaa Xaa Xaa Val  Xaa Xaa Xaa Ala Ser  Asn Asn Asn 
    1895                 1900                 1905             


Xaa Ala  Pro Xaa Asn Ala Xaa  Tyr Pro Met Pro Xaa  Ala Lys Glu 
    1910                 1915                 1920             


His Tyr  Pro Val Ser Ser Pro  Ser Ser Pro Ser Pro  Pro Ala Gln 
    1925                 1930                 1935             


Pro Gly  Gly Val Ser Arg Asn  Ser Pro Leu Asp Cys  Gly Ser Ala 
    1940                 1945                 1950             


Ser Pro  Asn Lys Val Ala Ser  Ser Ser Glu Gln Glu  Ala Gly Ser 
    1955                 1960                 1965             


Pro Pro  Val Val Glu Xaa Xaa  Asn Xaa Arg Pro Pro  Asn Ser Ser 
    1970                 1975                 1980             


Ser Ser  Ser Gly Ser Ser Ser  Ala His Ser Asn Gln  Gln Gln Pro 
    1985                 1990                 1995             


Pro Gly  Ser Val Ser Gln Glu  Pro Arg Pro Pro Leu  Gln Gln Ser 
    2000                 2005                 2010             


Gln Val  Pro Pro Pro Glu Val  Arg Met Xaa Val Pro  Pro Leu Ala 
    2015                 2020                 2025             


Xaa Ser  Ser Ala Pro Val Ala  Val Pro Ser Xaa Ala  Pro Val Xaa 
    2030                 2035                 2040             


Tyr Pro  Met Pro Gln Xaa Pro  Met Gly Cys Pro Gln  Pro Xaa Pro 
    2045                 2050                 2055             


Lys Met  Glu Xaa Pro Ala Ile  Arg Pro Pro Pro His  Gly Xaa Xaa 
    2060                 2065                 2070             


Ala Pro  His Lys Asn Ser Ala  Ser Val Gln Asn Ser  Ser Val Ala 
    2075                 2080                 2085             


Val Leu  Ser Val Asn His Ile  Lys Arg Pro His Ser  Val Pro Ser 
    2090                 2095                 2100             


Ser Val  Gln Leu Pro Ser Xaa  Leu Ser Xaa Gln Ser  Ala Cys Gln 
    2105                 2110                 2115             


Asn Ser  Val His Pro Ala Asn  Lys Pro Ile Ala Pro  Asn Phe Ser 
    2120                 2125                 2130             


Ala Pro  Leu Pro Phe Gly Pro  Phe Ser Xaa Leu Phe  Glu Asn Ser 
    2135                 2140                 2145             


Pro Xaa  Ser Ala His Ala Phe  Trp Gly Gly Ser Val  Val Ser Ser 
    2150                 2155                 2160             


Gln Ser  Xaa Pro Glu Ser Met  Leu Ser Gly Lys Ser  Ser Tyr Leu 
    2165                 2170                 2175             


Pro Asn  Ser Asp Pro Leu His  Gln Ser Asp Xaa Ser  Lys Ala Pro 
    2180                 2185                 2190             


Gly Phe  Arg Pro Pro Leu Gln  Arg Pro Ala Pro Ser  Pro Ser Gly 
    2195                 2200                 2205             


Ile Val  Asn Met Asp Ser Pro  Tyr Gly Ser Val Xaa  Pro Ser Ser 
    2210                 2215                 2220             


Xaa His  Leu Gly Asn Phe Ala  Ser Asn Ile Ser Gly  Gly Gln Met 
    2225                 2230                 2235             


Tyr Gly  Pro Gly Ala Pro Leu  Gly Gly Ala Pro Ala  Ala Ala Asn 
    2240                 2245                 2250             


Phe Asn  Arg Gln His Phe Ser  Pro Leu Ser Leu Leu  Xaa Pro Cys 
    2255                 2260                 2265             


Ser Ser  Ala Ser Asn Asp Ser  Ser Ala Gln Ser Val  Ser Ser Gly 
    2270                 2275                 2280             


Val Arg  Ala Pro Ser Pro Ala  Pro Ser Ser Val Pro  Leu Gly Ser 
    2285                 2290                 2295             


Glu Lys  Pro Ser Asn Val Ser  Gln Asp Arg Lys Val  Pro Val Pro 
    2300                 2305                 2310             


Ile Gly  Xaa Glu Arg Ser Ala  Arg Ile Arg Gln Xaa  Gly Xaa Ser 
    2315                 2320                 2325             


Ala Pro  Ser Val Ile Gly Ser  Asn Leu Ser Xaa Ser  Val Gly His 
    2330                 2335                 2340             


Ser Gly  Ile Trp Ser Phe Glu  Gly Ile Gly Gly Asn  Gln Asp Lys 
    2345                 2350                 2355             


Val Asp  Trp Cys Asn Pro Gly  Met Gly Asn Pro Met  Ile His Arg 
    2360                 2365                 2370             


Pro Met  Ser Asp Pro Gly Val  Phe Ser Gln His Gln  Ala Met Glu 
    2375                 2380                 2385             


Arg Asp  Ser Xaa Gly Ile Val  Xaa Pro Ser Gly Xaa  Phe His Gln 
    2390                 2395                 2400             


His Val  Pro Ala Gly Tyr Met  Asp Phe Pro Lys Val  Gly Gly Met 
    2405                 2410                 2415             


Pro Phe  Ser Val Tyr Gly Asn  Ala Met Ile Pro Pro  Val Ala Pro 
    2420                 2425                 2430             


Ile Pro  Asp Gly Ala Gly Gly  Pro Ile Phe Asn Gly  Pro His Ala 
    2435                 2440                 2445             


Ala Asp  Pro Ser Trp Asn Ser  Leu Ile Lys Met Val  Ser Ser Ser 
    2450                 2455                 2460             


Xaa Glu  Asn Asn Gly Pro Gln  Xaa Val Trp Xaa Gly  Pro Trp Ala 
    2465                 2470                 2475             


Pro His  Met Asn Ser Val His  Met Asn Gln Leu Gly  
    2480                 2485                 2490 


<210> 2360
<211> 2487
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1138)..(1138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1206)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1272)..(1272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1308)..(1308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1415)..(1415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1421)..(1425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1431)..(1431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1433)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1447)..(1449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1461)..(1461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1492)..(1492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1528)..(1530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1562)..(1562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1567)..(1567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1575)..(1575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1590)..(1590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1619)..(1619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1639)..(1639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1652)..(1652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1658)..(1658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1663)..(1663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1666)..(1666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1670)..(1670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1708)..(1710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1714)..(1714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1722)..(1723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1729)..(1729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1732)..(1732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1734)..(1734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1737)..(1737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1746)..(1746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1749)..(1749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1783)..(1783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1795)..(1795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1800)..(1800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1807)..(1807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1822)..(1822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1850)..(1850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1854)..(1857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1863)..(1863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1867)..(1867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1869)..(1869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1885)..(1885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1889)..(1889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1893)..(1896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1898)..(1900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1906)..(1906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1909)..(1909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1912)..(1912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1917)..(1917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1971)..(1972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1974)..(1974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2020)..(2020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2026)..(2026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2036)..(2036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2040)..(2040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2046)..(2046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2054)..(2054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2059)..(2059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2069)..(2070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2107)..(2107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2110)..(2110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2140)..(2140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2147)..(2147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2163)..(2163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2186)..(2186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2217)..(2217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2221)..(2221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2263)..(2263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2313)..(2313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2322)..(2322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2324)..(2324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2336)..(2336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2389)..(2389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2393)..(2393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2397)..(2397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2461)..(2461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2468)..(2468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2471)..(2471)
<223> Selenocysteine

<400> 2360
Xaa Glu Glu Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu Val Ser Glu 
1               5                   10                  15      


Val Glu Ser Phe Ile Leu Asp Gln Asp Asp Leu Glu Asn Pro Met Leu 
            20                  25                  30          


Glu Xaa Ala Ser Lys Leu Leu Leu Ser Gly Xaa Ala Asp Gly Ala Asp 
        35                  40                  45              


Leu Arg Xaa Val Asp Pro Glu Xaa Gln Ala Arg Leu Glu Ala Leu Leu 
    50                  55                  60                  


Glu Ala Ala Gly Ile Gly Lys Leu Ser Xaa Ala Asp Gly Lys Ala Phe 
65                  70                  75                  80  


Ala Asp Pro Glu Val Leu Arg Arg Leu Xaa Ser Ser Val Ser Cys Ala 
                85                  90                  95      


Leu Asp Glu Ala Ala Ala Ala Leu Xaa Arg Met Arg Ala Glu Ser Xaa 
            100                 105                 110         


Ala Asn Ala Gly Gln Ser Asp Asn Arg Ser Leu Ala Glu Ala Cys Ser 
        115                 120                 125             


Glu Gly Asp Val Asn Ala Val Arg Lys Leu Leu Ile Glu Gly Arg Ser 
    130                 135                 140                 


Val Asn Glu His Xaa Glu Glu Gly Glu Ser Leu Leu Cys Leu Ala Cys 
145                 150                 155                 160 


Ser Ala Gly Tyr Tyr Glu Leu Ala Gln Val Leu Leu Ala Met His Ala 
                165                 170                 175     


Asn Val Glu Asp Arg Gly Ile Lys Gly Asp Ile Xaa Pro Leu Met Ala 
            180                 185                 190         


Ala Ala Asn Gly Gly His Val Lys Ile Val Lys Leu Leu Leu Ala His 
        195                 200                 205             


Lys Ala Asp Val Asn Ala Gln Ser Ser Xaa Gly Asn Xaa Ala Leu Xaa 
    210                 215                 220                 


Tyr Ala Cys Ala Gly Gly Tyr Val Asp Val Val Lys Val Leu Leu Glu 
225                 230                 235                 240 


Ser Gly Ala Ser Ile Glu Asp His Asn Glu Asn Gly His Xaa Pro Leu 
                245                 250                 255     


Met Glu Ala Gly Ser Ala Gly His Val Glu Val Ala Arg Leu Leu Leu 
            260                 265                 270         


Glu Asn Gly Ala Gly Ile Asn Xaa His Ser Asn Glu Phe Lys Glu Ser 
        275                 280                 285             


Ala Leu Xaa Leu Ala Cys Tyr Lys Gly His Leu Glu Met Val Arg Phe 
    290                 295                 300                 


Leu Leu Glu Ala Gly Ala Asp Gln Glu His Lys Xaa Asp Glu Met His 
305                 310                 315                 320 


Xaa Ala Leu Met Glu Ala Cys Met Asp Gly His Val Glu Val Ala Arg 
                325                 330                 335     


Leu Leu Leu Asp Ser Gly Ala Gln Val Asn Met Pro Ala Asp Ser Phe 
            340                 345                 350         


Glu Ser Pro Leu Xaa Leu Ala Ala Cys Gly Gly His Val Glu Leu Ala 
        355                 360                 365             


Ala Leu Leu Ile Glu Arg Gly Ala Ser Leu Glu Glu Val Asn Asp Glu 
    370                 375                 380                 


Gly Tyr Xaa Pro Leu Met Glu Ala Ala Arg Glu Gly His Glu Glu Met 
385                 390                 395                 400 


Val Ala Leu Leu Leu Gly Gln Gly Ala Asn Ile Asn Ala Gln Xaa Glu 
                405                 410                 415     


Glu Xaa Gln Glu Xaa Ala Leu Xaa Leu Ala Cys Cys Gly Gly Phe Leu 
            420                 425                 430         


Glu Val Ala Asp Phe Leu Ile Lys Ala Gly Ala Asp Ile Glu Leu Gly 
        435                 440                 445             


Cys Ser Xaa Pro Leu Met Glu Ala Ala Gln Glu Gly His Leu Glu Leu 
    450                 455                 460                 


Val Lys Tyr Leu Leu Ala Ala Gly Ala Asn Val His Ala Xaa Xaa Ala 
465                 470                 475                 480 


Xaa Gly Asp Xaa Ala Leu Xaa Tyr Ala Cys Glu Asn Gly His Xaa Asp 
                485                 490                 495     


Val Ala Asp Val Leu Leu Gln Ala Gly Ala Asp Leu Glu His Glu Ser 
            500                 505                 510         


Glu Gly Gly Arg Xaa Pro Leu Met Lys Ala Ala Arg Ala Gly His Val 
        515                 520                 525             


Cys Xaa Val Gln Phe Leu Ile Ser Lys Gly Ala Asn Val Asn Arg Xaa 
    530                 535                 540                 


Xaa Ala Asn Asn Asp His Xaa Val Leu Ser Leu Ala Cys Ala Gly Gly 
545                 550                 555                 560 


His Leu Ala Val Val Glu Leu Leu Leu Ala His Gly Ala Asp Pro Xaa 
                565                 570                 575     


His Arg Leu Lys Asp Gly Ser Xaa Met Leu Ile Glu Ala Ala Lys Gly 
            580                 585                 590         


Gly His Xaa Ser Val Val Cys Tyr Leu Leu Asp Tyr Pro Asn Asn Leu 
        595                 600                 605             


Leu Ser Ala Pro Pro Pro Asp Val Xaa Gln Leu Xaa Pro Pro Ser His 
    610                 615                 620                 


Asp Leu Asn Arg Ala Pro Arg Val Pro Val Gln Ala Leu Pro Met Val 
625                 630                 635                 640 


Val Pro Pro Gln Glu Pro Asp Lys Pro Pro Ala Asn Val Ala Xaa Xaa 
                645                 650                 655     


Leu Pro Ile Arg Asn Lys Ala Ala Ser Lys Gln Lys Ser Ser Ser His 
            660                 665                 670         


Leu Pro Ala Asn Ser Gln Asp Val Gln Gly Tyr Ile Xaa Asn Gln Ser 
        675                 680                 685             


Pro Glu Ser Ile Val Glu Glu Ala Gln Gly Lys Leu Xaa Glu Leu Glu 
    690                 695                 700                 


Gln Arg Ile Lys Glu Ala Ile Glu Lys Asn Ala Gln Leu Gln Ser Leu 
705                 710                 715                 720 


Glu Leu Ala His Ala Asp Gln Leu Xaa Lys Glu Lys Ile Glu Glu Leu 
                725                 730                 735     


Asn Lys Xaa Arg Glu Glu Gln Ile Gln Lys Lys Gln Lys Ile Leu Glu 
            740                 745                 750         


Glu Leu Gln Lys Val Glu Arg Glu Leu Gln Leu Lys Xaa Gln Gln Gln 
        755                 760                 765             


Leu Lys Lys Gln Tyr Leu Glu Val Lys Ala Gln Arg Ile Gln Leu Gln 
    770                 775                 780                 


Gln Gln Gln Gln Gln Ser Cys Gln His Leu Gly Leu Leu Xaa Pro Val 
785                 790                 795                 800 


Gly Val Gly Glu Gln Leu Ser Glu Gly Asp Tyr Ala Arg Leu Gln Gln 
                805                 810                 815     


Val Asp Pro Val Leu Leu Lys Asp Glu Pro Gln Gln Xaa Ala Ala Gln 
            820                 825                 830         


Met Gly Phe Ala Pro Ile Gln Pro Leu Ala Met Pro Gln Ala Leu Pro 
        835                 840                 845             


Leu Ala Ala Gly Pro Leu Pro Pro Gly Ser Ile Ala Asn Leu Xaa Glu 
    850                 855                 860                 


Leu Gln Gly Val Ile Val Gly Gln Pro Val Leu Gly Gln Ala Gln Leu 
865                 870                 875                 880 


Ala Gly Leu Gly Gln Gly Ile Leu Xaa Glu Xaa Gln Gln Gly Leu Met 
                885                 890                 895     


Val Ala Ser Pro Ala Gln Xaa Leu Asn Asp Xaa Leu Asp Asp Ile Met 
            900                 905                 910         


Ala Val Ser Gly Arg Ala Ser Ala Met Ser Asn Xaa Pro Xaa His Ser 
        915                 920                 925             


Ile Ala Ala Ser Ile Ser Gln Pro Gln Xaa Pro Xaa Pro Ser Pro Ile 
    930                 935                 940                 


Ile Ser Pro Ser Ala Met Leu Pro Ile Tyr Pro Ala Ile Asp Ile Asp 
945                 950                 955                 960 


Ala Gln Xaa Glu Ser Asn His Asp Xaa Ala Leu Xaa Leu Ala Cys Ala 
                965                 970                 975     


Gly Gly His Glu Glu Leu Val Gln Xaa Leu Leu Glu Arg Gly Ala Ser 
            980                 985                 990         


Ile Glu His Arg Asp Lys Lys Gly  Phe Xaa Pro Leu Ile  Leu Ala Ala 
        995                 1000                 1005             


Xaa Ala  Gly His Val Gly Val  Val Glu Ile Leu Leu  Asp Asn Gly 
    1010                 1015                 1020             


Ala Asp  Ile Glu Ala Gln Ser  Glu Arg Xaa Lys Asp  Xaa Pro Leu 
    1025                 1030                 1035             


Ser Leu  Ala Cys Ser Gly Gly  Arg Gln Glu Val Val  Glu Leu Leu 
    1040                 1045                 1050             


Leu Ala  Arg Gly Ala Asn Lys  Glu His Arg Asn Val  Ser Asp Tyr 
    1055                 1060                 1065             


Xaa Pro  Leu Ser Leu Ala Ala  Ser Gly Gly Tyr Val  Asn Ile Ile 
    1070                 1075                 1080             


Lys Ile  Leu Leu Asn Ala Gly  Ala Glu Ile Asn Ser  Arg Xaa Gly 
    1085                 1090                 1095             


Ser Lys  Leu Gly Ile Ser Pro  Leu Met Leu Ala Ala  Met Asn Gly 
    1100                 1105                 1110             


His Xaa  Ala Ala Val Lys Leu  Leu Leu Asp Met Gly  Ser Asp Ile 
    1115                 1120                 1125             


Asn Ala  Gln Ile Glu Xaa Asn  Arg Asn Xaa Ala Leu  Xaa Leu Ala 
    1130                 1135                 1140             


Cys Phe  Gln Gly Arg Xaa Glu  Val Val Ser Leu Leu  Leu Asp Arg 
    1145                 1150                 1155             


Lys Ala  Asn Val Glu His Arg  Ala Lys Xaa Gly Leu  Xaa Pro Leu 
    1160                 1165                 1170             


Met Glu  Ala Ala Ser Gly Gly  Tyr Ala Glu Val Gly  Arg Val Leu 
    1175                 1180                 1185             


Leu Asp  Lys Gly Ala Asp Val  Asn Ala Pro Pro Val  Pro Ser Ser 
    1190                 1195                 1200             


Arg Asp  Xaa Ala Leu Xaa Ile  Ala Ala Asp Lys Gly  His Tyr Lys 
    1205                 1210                 1215             


Phe Cys  Glu Leu Leu Ile Gly  Arg Gly Ala His Ile  Asp Val Arg 
    1220                 1225                 1230             


Asn Lys  Lys Gly Asn Xaa Pro  Leu Trp Leu Ala Ala  Asn Gly Gly 
    1235                 1240                 1245             


His Leu  Asp Val Val Gln Leu  Leu Val Gln Ala Gly  Ala Asp Val 
    1250                 1255                 1260             


Asp Ala  Ala Asp Asn Arg Lys  Ile Xaa Pro Leu Met  Ala Ala Phe 
    1265                 1270                 1275             


Arg Lys  Gly His Val Lys Val  Val Arg Tyr Leu Val  Lys Glu Val 
    1280                 1285                 1290             


Asn Gln  Phe Pro Ser Asp Ser  Glu Cys Met Arg Tyr  Ile Ala Xaa 
    1295                 1300                 1305             


Ile Xaa  Asp Lys Glu Met Leu  Lys Lys Cys His Leu  Cys Met Glu 
    1310                 1315                 1320             


Ser Ile  Val Gln Ala Lys Asp  Arg Gln Ala Ala Glu  Ala Asn Lys 
    1325                 1330                 1335             


Asn Ala  Ser Ile Leu Leu Glu  Glu Leu Asp Leu Glu  Lys Leu Arg 
    1340                 1345                 1350             


Glu Glu  Ser Arg Arg Leu Ala  Leu Ala Ala Lys Arg  Glu Lys Arg 
    1355                 1360                 1365             


Lys Glu  Lys Arg Arg Lys Lys  Lys Glu Glu Gln Arg  Arg Lys Leu 
    1370                 1375                 1380             


Glu Glu  Ile Glu Ala Lys Asn  Lys Glu Asn Phe Glu  Leu Gln Ala 
    1385                 1390                 1395             


Ala Gln  Glu Lys Glu Lys Leu  Lys Val Glu Asp Glu  Pro Glu Val 
    1400                 1405                 1410             


Leu Xaa  Glu Pro Pro Ser Ala  Xaa Xaa Xaa Xaa Xaa  Ile Gly Ile 
    1415                 1420                 1425             


Ser Ala  Xaa Trp Xaa Xaa Leu  Ala Gly Ser His Gly  Lys Arg Asn 
    1430                 1435                 1440             


Asn Xaa  Ile Xaa Xaa Xaa Ser  Ser Lys Arg Lys Asn  Arg Lys Asn 
    1445                 1450                 1455             


Lys Ile  Xaa Pro Glu Asn Val  Gln Ile Ile Phe Asp  Asp Pro Leu 
    1460                 1465                 1470             


Pro Ile  Ser Tyr Ser Gln Pro  Glu Lys Val Asn Gly  Glu Ser Lys 
    1475                 1480                 1485             


Ser Ser  Ser Xaa Ser Glu Ser  Gly Asp Ser Asp Asn  Met Arg Ile 
    1490                 1495                 1500             


Ser Ser  Cys Ser Asp Glu Ser  Ser Asn Ser Asn Ser  Ser Arg Lys 
    1505                 1510                 1515             


Ser Asp  Asn His Ser Pro Ala  Val Val Xaa Xaa Xaa  Val Ser Ser 
    1520                 1525                 1530             


Lys Lys  Gln Pro Ser Val Leu  Val Xaa Phe Pro Lys  Glu Glu Arg 
    1535                 1540                 1545             


Lys Ser  Val Ser Gly Lys Ala  Ser Ile Lys Leu Ser  Glu Xaa Ile 
    1550                 1555                 1560             


Ser Glu  Gly Xaa Ser Asn Ser  Leu Ser Xaa Cys Xaa  Lys Ser Gly 
    1565                 1570                 1575             


Pro Ser  Pro Leu Ser Ser Pro  Asn Gly Lys Leu Xaa  Val Ala Ser 
    1580                 1585                 1590             


Pro Lys  Arg Gly Gln Lys Arg  Glu Glu Gly Trp Lys  Glu Val Val 
    1595                 1600                 1605             


Arg Arg  Ser Lys Lys Val Ser  Val Pro Ser Xaa Val  Ile Ser Arg 
    1610                 1615                 1620             


Val Ile  Gly Arg Gly Gly Cys  Asn Ile Asn Ala Ile  Arg Glu Phe 
    1625                 1630                 1635             


Xaa Gly  Ala His Ile Asp Ile  Asp Lys Gln Lys Asp  Lys Xaa Gly 
    1640                 1645                 1650             


Asp Arg  Ile Ile Xaa Ile Arg  Gly Gly Xaa Glu Ser  Xaa Arg Gln 
    1655                 1660                 1665             


Ala Xaa  Gln Leu Ile Asn Ala  Leu Ile Lys Asp Pro  Asp Lys Glu 
    1670                 1675                 1680             


Ile Asp  Glu Leu Ile Pro Lys  Asn Arg Leu Lys Ser  Ser Ser Ala 
    1685                 1690                 1695             


Asn Ser  Lys Ile Gly Ser Ser  Ala Pro Xaa Xaa Xaa  Ala Ala Asn 
    1700                 1705                 1710             


Xaa Ser  Leu Met Gly Ile Lys  Met Xaa Xaa Val Ala  Leu Ser Ser 
    1715                 1720                 1725             


Xaa Ser  Gln Xaa Ala Xaa Ala  Leu Xaa Val Pro Ala  Ile Ser Ser 
    1730                 1735                 1740             


Ala Ser  Xaa His Lys Xaa Ile  Lys Asn Pro Val Asn  Asn Val Arg 
    1745                 1750                 1755             


Pro Gly  Phe Pro Val Ser Leu  Pro Leu Ala Tyr Pro  Pro Pro Gln 
    1760                 1765                 1770             


Phe Ala  His Ala Leu Leu Ala  Ala Gln Xaa Phe Gln  Gln Ile Arg 
    1775                 1780                 1785             


Pro Pro  Arg Leu Pro Met Xaa  His Phe Gly Gly Xaa  Phe Pro Pro 
    1790                 1795                 1800             


Ala Gln  Ser Xaa Trp Gly Pro  Phe Pro Val Arg Pro  Leu Ser Pro 
    1805                 1810                 1815             


Ala Arg  Ala Xaa Asn Ser Pro  Lys Pro His Met Val  Pro Arg His 
    1820                 1825                 1830             


Ser Asn  Gln Asn Ser Ser Gly  Ser Gln Val Asn Ser  Ala Gly Ser 
    1835                 1840                 1845             


Leu Xaa  Ser Ser Pro Xaa Xaa  Xaa Xaa Ser Ser Ser  Ala Ser Xaa 
    1850                 1855                 1860             


Val Pro  Gly Xaa Ser Xaa Asn  Gly Ser Pro Ser Ser  Pro Ser Val 
    1865                 1870                 1875             


Arg Arg  Gln Leu Phe Val Xaa  Val Val Lys Xaa Ser  Asn Ala Xaa 
    1880                 1885                 1890             


Xaa Xaa  Xaa Val Xaa Xaa Xaa  Ala Ser Asn Asn Asn  Xaa Ala Pro 
    1895                 1900                 1905             


Xaa Asn  Ala Xaa Tyr Pro Met  Pro Xaa Ala Lys Glu  His Tyr Pro 
    1910                 1915                 1920             


Val Ser  Ser Pro Ser Ser Pro  Ser Pro Pro Ala Gln  Pro Gly Gly 
    1925                 1930                 1935             


Val Ser  Arg Asn Ser Pro Leu  Asp Cys Gly Ser Ala  Ser Pro Asn 
    1940                 1945                 1950             


Lys Val  Ala Ser Ser Ser Glu  Gln Glu Ala Gly Ser  Pro Pro Val 
    1955                 1960                 1965             


Val Glu  Xaa Xaa Asn Xaa Arg  Pro Pro Asn Ser Ser  Ser Ser Ser 
    1970                 1975                 1980             


Gly Ser  Ser Ser Ala His Ser  Asn Gln Gln Gln Pro  Pro Gly Ser 
    1985                 1990                 1995             


Val Ser  Gln Glu Pro Arg Pro  Pro Leu Gln Gln Ser  Gln Val Pro 
    2000                 2005                 2010             


Pro Pro  Glu Val Arg Met Xaa  Val Pro Pro Leu Ala  Xaa Ser Ser 
    2015                 2020                 2025             


Ala Pro  Val Ala Val Pro Ser  Xaa Ala Pro Val Xaa  Tyr Pro Met 
    2030                 2035                 2040             


Pro Gln  Xaa Pro Met Gly Cys  Pro Gln Pro Xaa Pro  Lys Met Glu 
    2045                 2050                 2055             


Xaa Pro  Ala Ile Arg Pro Pro  Pro His Gly Xaa Xaa  Ala Pro His 
    2060                 2065                 2070             


Lys Asn  Ser Ala Ser Val Gln  Asn Ser Ser Val Ala  Val Leu Ser 
    2075                 2080                 2085             


Val Asn  His Ile Lys Arg Pro  His Ser Val Pro Ser  Ser Val Gln 
    2090                 2095                 2100             


Leu Pro  Ser Xaa Leu Ser Xaa  Gln Ser Ala Cys Gln  Asn Ser Val 
    2105                 2110                 2115             


His Pro  Ala Asn Lys Pro Ile  Ala Pro Asn Phe Ser  Ala Pro Leu 
    2120                 2125                 2130             


Pro Phe  Gly Pro Phe Ser Xaa  Leu Phe Glu Asn Ser  Pro Xaa Ser 
    2135                 2140                 2145             


Ala His  Ala Phe Trp Gly Gly  Ser Val Val Ser Ser  Gln Ser Xaa 
    2150                 2155                 2160             


Pro Glu  Ser Met Leu Ser Gly  Lys Ser Ser Tyr Leu  Pro Asn Ser 
    2165                 2170                 2175             


Asp Pro  Leu His Gln Ser Asp  Xaa Ser Lys Ala Pro  Gly Phe Arg 
    2180                 2185                 2190             


Pro Pro  Leu Gln Arg Pro Ala  Pro Ser Pro Ser Gly  Ile Val Asn 
    2195                 2200                 2205             


Met Asp  Ser Pro Tyr Gly Ser  Val Xaa Pro Ser Ser  Xaa His Leu 
    2210                 2215                 2220             


Gly Asn  Phe Ala Ser Asn Ile  Ser Gly Gly Gln Met  Tyr Gly Pro 
    2225                 2230                 2235             


Gly Ala  Pro Leu Gly Gly Ala  Pro Ala Ala Ala Asn  Phe Asn Arg 
    2240                 2245                 2250             


Gln His  Phe Ser Pro Leu Ser  Leu Leu Xaa Pro Cys  Ser Ser Ala 
    2255                 2260                 2265             


Ser Asn  Asp Ser Ser Ala Gln  Ser Val Ser Ser Gly  Val Arg Ala 
    2270                 2275                 2280             


Pro Ser  Pro Ala Pro Ser Ser  Val Pro Leu Gly Ser  Glu Lys Pro 
    2285                 2290                 2295             


Ser Asn  Val Ser Gln Asp Arg  Lys Val Pro Val Pro  Ile Gly Xaa 
    2300                 2305                 2310             


Glu Arg  Ser Ala Arg Ile Arg  Gln Xaa Gly Xaa Ser  Ala Pro Ser 
    2315                 2320                 2325             


Val Ile  Gly Ser Asn Leu Ser  Xaa Ser Val Gly His  Ser Gly Ile 
    2330                 2335                 2340             


Trp Ser  Phe Glu Gly Ile Gly  Gly Asn Gln Asp Lys  Val Asp Trp 
    2345                 2350                 2355             


Cys Asn  Pro Gly Met Gly Asn  Pro Met Ile His Arg  Pro Met Ser 
    2360                 2365                 2370             


Asp Pro  Gly Val Phe Ser Gln  His Gln Ala Met Glu  Arg Asp Ser 
    2375                 2380                 2385             


Xaa Gly  Ile Val Xaa Pro Ser  Gly Xaa Phe His Gln  His Val Pro 
    2390                 2395                 2400             


Ala Gly  Tyr Met Asp Phe Pro  Lys Val Gly Gly Met  Pro Phe Ser 
    2405                 2410                 2415             


Val Tyr  Gly Asn Ala Met Ile  Pro Pro Val Ala Pro  Ile Pro Asp 
    2420                 2425                 2430             


Gly Ala  Gly Gly Pro Ile Phe  Asn Gly Pro His Ala  Ala Asp Pro 
    2435                 2440                 2445             


Ser Trp  Asn Ser Leu Ile Lys  Met Val Ser Ser Ser  Xaa Glu Asn 
    2450                 2455                 2460             


Asn Gly  Pro Gln Xaa Val Trp  Xaa Gly Pro Trp Ala  Pro His Met 
    2465                 2470                 2475             


Asn Ser  Val His Met Asn Gln  Leu Gly 
    2480                 2485         


<210> 2361
<211> 327
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<400> 2361
Met Ala Lys Ala Pro Ser Trp Ala Gly Val Gly Ala Leu Ala Tyr Lys 
1               5                   10                  15      


Ala Pro Glu Ala Leu Trp Pro Ala Glu Ala Val Met Asp Gly Xaa Met 
            20                  25                  30          


Glu Asp Ser Glu Ala Val Gln Arg Ala Xaa Ala Leu Ile Glu Gln Arg 
        35                  40                  45              


Leu Ala Gln Glu Glu Glu Asn Glu Lys Leu Arg Gly Asp Ala Arg Gln 
    50                  55                  60                  


Lys Leu Pro Met Asp Leu Leu Val Leu Glu Asp Glu Lys His His Gly 
65                  70                  75                  80  


Ala Gln Ser Ala Ala Leu Gln Lys Val Lys Gly Gln Glu Arg Val Arg 
                85                  90                  95      


Lys Xaa Ser Leu Asp Leu Arg Arg Glu Ile Ile Asp Val Gly Gly Ile 
            100                 105                 110         


Gln Asn Leu Ile Glu Leu Arg Lys Lys Arg Lys Gln Lys Lys Arg Asp 
        115                 120                 125             


Ala Leu Ala Ala Ser His Glu Pro Pro Pro Glu Pro Glu Glu Ile Xaa 
    130                 135                 140                 


Gly Pro Val Asp Glu Glu Xaa Phe Leu Lys Ala Ala Val Glu Gly Lys 
145                 150                 155                 160 


Met Lys Val Ile Glu Lys Phe Leu Ala Asp Gly Gly Ser Ala Asp Xaa 
                165                 170                 175     


Cys Asp Gln Phe Arg Arg Xaa Ala Leu His Arg Ala Ser Leu Glu Gly 
            180                 185                 190         


His Met Glu Ile Leu Glu Lys Leu Leu Asp Asn Gly Ala Xaa Val Asp 
        195                 200                 205             


Phe Gln Asp Arg Leu Asp Cys Xaa Ala Met His Trp Ala Cys Arg Gly 
    210                 215                 220                 


Gly His Leu Glu Val Val Lys Leu Leu Gln Ser His Gly Ala Asp Xaa 
225                 230                 235                 240 


Asn Val Arg Asp Lys Glu Gly Asp Xaa Ala Leu His Asp Ala Val Arg 
                245                 250                 255     


Leu Asn Arg Tyr Lys Ile Ile Lys Leu Leu Leu Leu His Gly Ala Asp 
            260                 265                 270         


Met Met Xaa Lys Asn Leu Ala Gly Lys Xaa Pro Xaa Asp Leu Val Gln 
        275                 280                 285             


Leu Trp Gln Ala Asp Xaa Arg His Ala Leu Glu His Pro Glu Pro Gly 
    290                 295                 300                 


Ala Glu His Asn Gly Leu Glu Gly Pro Asn Asp Ser Gly Arg Glu Xaa 
305                 310                 315                 320 


Pro Gln Pro Val Pro Ala Gln 
                325         


<210> 2362
<211> 360
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<400> 2362
Met Ala Lys Ala Pro Ser Trp Ala Gly Val Gly Ala Leu Ala Tyr Lys 
1               5                   10                  15      


Ala Pro Glu Ala Leu Trp Pro Ala Glu Ala Val Met Asp Gly Xaa Met 
            20                  25                  30          


Glu Asp Ser Glu Ala Val Gln Arg Ala Xaa Ala Leu Ile Glu Gln Arg 
        35                  40                  45              


Leu Ala Gln Glu Glu Glu Asn Glu Lys Leu Arg Gly Asp Ala Arg Gln 
    50                  55                  60                  


Lys Leu Pro Met Asp Leu Leu Val Leu Glu Asp Glu Lys His His Gly 
65                  70                  75                  80  


Ala Gln Ser Ala Ala Leu Gln Lys Val Lys Gly Gln Glu Arg Val Arg 
                85                  90                  95      


Lys Xaa Ser Leu Asp Leu Arg Arg Glu Ile Ile Asp Val Gly Gly Ile 
            100                 105                 110         


Gln Asn Leu Ile Glu Leu Arg Lys Lys Arg Lys Gln Lys Lys Arg Asp 
        115                 120                 125             


Ala Leu Ala Ala Ser His Glu Pro Pro Pro Glu Pro Glu Glu Ile Xaa 
    130                 135                 140                 


Gly Pro Val Asp Glu Glu Xaa Phe Leu Lys Ala Ala Val Glu Gly Lys 
145                 150                 155                 160 


Met Lys Val Ile Glu Lys Phe Leu Ala Asp Gly Gly Ser Ala Asp Xaa 
                165                 170                 175     


Cys Asp Gln Phe Arg Arg Xaa Ala Leu His Arg Ala Ser Leu Glu Gly 
            180                 185                 190         


His Met Glu Ile Leu Glu Lys Leu Leu Asp Asn Gly Ala Xaa Val Asp 
        195                 200                 205             


Phe Gln Asp Arg Leu Asp Cys Xaa Ala Met His Trp Ala Cys Arg Gly 
    210                 215                 220                 


Gly His Leu Glu Val Val Lys Leu Leu Gln Ser His Gly Ala Asp Xaa 
225                 230                 235                 240 


Asn Val Arg Asp Lys Leu Leu Ser Xaa Pro Leu His Val Ala Val Arg 
                245                 250                 255     


Xaa Gly Gln Val Glu Ile Val Glu His Phe Leu Ser Leu Gly Leu Glu 
            260                 265                 270         


Ile Asn Ala Arg Asp Arg Glu Gly Asp Xaa Ala Leu His Asp Ala Val 
        275                 280                 285             


Arg Leu Asn Arg Tyr Lys Ile Ile Lys Leu Leu Leu Leu His Gly Ala 
    290                 295                 300                 


Asp Met Met Xaa Lys Asn Leu Ala Gly Lys Xaa Pro Xaa Asp Leu Val 
305                 310                 315                 320 


Gln Leu Trp Gln Ala Asp Xaa Arg His Ala Leu Glu His Pro Glu Pro 
                325                 330                 335     


Gly Ala Glu His Asn Gly Leu Glu Gly Pro Asn Asp Ser Gly Arg Glu 
            340                 345                 350         


Xaa Pro Gln Pro Val Pro Ala Gln 
        355                 360 


<210> 2363
<211> 300
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<400> 2363
Met Asp Gly Xaa Met Glu Asp Ser Glu Ala Val Gln Arg Ala Xaa Ala 
1               5                   10                  15      


Leu Ile Glu Gln Arg Leu Ala Gln Glu Glu Glu Asn Glu Lys Leu Arg 
            20                  25                  30          


Gly Asp Ala Arg Gln Lys Leu Pro Met Asp Leu Leu Val Leu Glu Asp 
        35                  40                  45              


Glu Lys His His Gly Ala Gln Ser Ala Ala Leu Gln Lys Val Lys Gly 
    50                  55                  60                  


Gln Glu Arg Val Arg Lys Xaa Ser Leu Asp Leu Arg Arg Glu Ile Ile 
65                  70                  75                  80  


Asp Val Gly Gly Ile Gln Asn Leu Ile Glu Leu Arg Lys Lys Arg Lys 
                85                  90                  95      


Gln Lys Lys Arg Asp Ala Leu Ala Ala Ser His Glu Pro Pro Pro Glu 
            100                 105                 110         


Pro Glu Glu Ile Xaa Gly Pro Val Asp Glu Glu Xaa Phe Leu Lys Ala 
        115                 120                 125             


Ala Val Glu Gly Lys Met Lys Val Ile Glu Lys Phe Leu Ala Asp Gly 
    130                 135                 140                 


Gly Ser Ala Asp Xaa Cys Asp Gln Phe Arg Arg Xaa Ala Leu His Arg 
145                 150                 155                 160 


Ala Ser Leu Glu Gly His Met Glu Ile Leu Glu Lys Leu Leu Asp Asn 
                165                 170                 175     


Gly Ala Xaa Val Asp Phe Gln Asp Arg Leu Asp Cys Xaa Ala Met His 
            180                 185                 190         


Trp Ala Cys Arg Gly Gly His Leu Glu Val Val Lys Leu Leu Gln Ser 
        195                 200                 205             


His Gly Ala Asp Xaa Asn Val Arg Asp Lys Glu Gly Asp Xaa Ala Leu 
    210                 215                 220                 


His Asp Ala Val Arg Leu Asn Arg Tyr Lys Ile Ile Lys Leu Leu Leu 
225                 230                 235                 240 


Leu His Gly Ala Asp Met Met Xaa Lys Asn Leu Ala Gly Lys Xaa Pro 
                245                 250                 255     


Xaa Asp Leu Val Gln Leu Trp Gln Ala Asp Xaa Arg His Ala Leu Glu 
            260                 265                 270         


His Pro Glu Pro Gly Ala Glu His Asn Gly Leu Glu Gly Pro Asn Asp 
        275                 280                 285             


Ser Gly Arg Glu Xaa Pro Gln Pro Val Pro Ala Gln 
    290                 295                 300 


<210> 2364
<211> 333
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<400> 2364
Met Asp Gly Xaa Met Glu Asp Ser Glu Ala Val Gln Arg Ala Xaa Ala 
1               5                   10                  15      


Leu Ile Glu Gln Arg Leu Ala Gln Glu Glu Glu Asn Glu Lys Leu Arg 
            20                  25                  30          


Gly Asp Ala Arg Gln Lys Leu Pro Met Asp Leu Leu Val Leu Glu Asp 
        35                  40                  45              


Glu Lys His His Gly Ala Gln Ser Ala Ala Leu Gln Lys Val Lys Gly 
    50                  55                  60                  


Gln Glu Arg Val Arg Lys Xaa Ser Leu Asp Leu Arg Arg Glu Ile Ile 
65                  70                  75                  80  


Asp Val Gly Gly Ile Gln Asn Leu Ile Glu Leu Arg Lys Lys Arg Lys 
                85                  90                  95      


Gln Lys Lys Arg Asp Ala Leu Ala Ala Ser His Glu Pro Pro Pro Glu 
            100                 105                 110         


Pro Glu Glu Ile Xaa Gly Pro Val Asp Glu Glu Xaa Phe Leu Lys Ala 
        115                 120                 125             


Ala Val Glu Gly Lys Met Lys Val Ile Glu Lys Phe Leu Ala Asp Gly 
    130                 135                 140                 


Gly Ser Ala Asp Xaa Cys Asp Gln Phe Arg Arg Xaa Ala Leu His Arg 
145                 150                 155                 160 


Ala Ser Leu Glu Gly His Met Glu Ile Leu Glu Lys Leu Leu Asp Asn 
                165                 170                 175     


Gly Ala Xaa Val Asp Phe Gln Asp Arg Leu Asp Cys Xaa Ala Met His 
            180                 185                 190         


Trp Ala Cys Arg Gly Gly His Leu Glu Val Val Lys Leu Leu Gln Ser 
        195                 200                 205             


His Gly Ala Asp Xaa Asn Val Arg Asp Lys Leu Leu Ser Xaa Pro Leu 
    210                 215                 220                 


His Val Ala Val Arg Xaa Gly Gln Val Glu Ile Val Glu His Phe Leu 
225                 230                 235                 240 


Ser Leu Gly Leu Glu Ile Asn Ala Arg Asp Arg Glu Gly Asp Xaa Ala 
                245                 250                 255     


Leu His Asp Ala Val Arg Leu Asn Arg Tyr Lys Ile Ile Lys Leu Leu 
            260                 265                 270         


Leu Leu His Gly Ala Asp Met Met Xaa Lys Asn Leu Ala Gly Lys Xaa 
        275                 280                 285             


Pro Xaa Asp Leu Val Gln Leu Trp Gln Ala Asp Xaa Arg His Ala Leu 
    290                 295                 300                 


Glu His Pro Glu Pro Gly Ala Glu His Asn Gly Leu Glu Gly Pro Asn 
305                 310                 315                 320 


Asp Ser Gly Arg Glu Xaa Pro Gln Pro Val Pro Ala Gln 
                325                 330             


<210> 2365
<211> 1397
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1093)..(1093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1120)..(1120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1176)..(1176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1179)..(1179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1214)..(1214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1278)..(1278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1291)..(1291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1313)..(1313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1394)..(1394)
<223> Selenocysteine

<400> 2365
Met Glu Glu Ile Ser Ala Ala Ala Val Lys Val Val Pro Gly Pro Glu 
1               5                   10                  15      


Arg Pro Ser Pro Phe Ser Gln Leu Val Tyr Xaa Ser Asn Asp Ser Tyr 
            20                  25                  30          


Ile Val His Ser Gly Asp Leu Arg Lys Ile His Lys Ala Ala Ser Arg 
        35                  40                  45              


Gly Gln Val Arg Lys Leu Glu Lys Met Xaa Lys Arg Lys Lys Xaa Ile 
    50                  55                  60                  


Asn Leu Asn Ile Gln Asp Ala Gln Lys Arg Xaa Ala Leu His Trp Ala 
65                  70                  75                  80  


Cys Val Asn Gly His Glu Glu Val Val Xaa Phe Leu Val Asp Arg Lys 
                85                  90                  95      


Cys Gln Leu Asp Val Leu Asp Gly Glu His Arg Xaa Pro Leu Met Lys 
            100                 105                 110         


Ala Leu Gln Cys His Gln Glu Ala Cys Ala Asn Ile Leu Ile Asp Ser 
        115                 120                 125             


Gly Ala Asp Ile Asn Leu Val Asp Val Tyr Gly Asn Xaa Ala Leu His 
    130                 135                 140                 


Tyr Ala Val Tyr Ser Glu Ile Leu Ser Val Val Ala Lys Leu Leu Ser 
145                 150                 155                 160 


His Gly Ala Val Ile Glu Val His Asn Lys Ala Ser Leu Xaa Pro Leu 
                165                 170                 175     


Leu Leu Ser Ile Xaa Lys Arg Ser Glu Gln Ile Val Glu Phe Leu Leu 
            180                 185                 190         


Ile Lys Asn Ala Asn Ala Asn Ala Val Asn Lys Tyr Lys Cys Xaa Ala 
        195                 200                 205             


Leu Met Leu Ala Val Cys His Gly Ser Ser Glu Ile Val Gly Met Leu 
    210                 215                 220                 


Leu Gln Gln Asn Val Asp Val Phe Ala Ala Asp Ile Cys Gly Val Xaa 
225                 230                 235                 240 


Ala Glu His Tyr Ala Val Xaa Cys Gly Phe His His Ile His Glu Gln 
                245                 250                 255     


Ile Met Glu Tyr Ile Arg Lys Leu Ser Lys Asn His Gln Asn Xaa Asn 
            260                 265                 270         


Pro Glu Gly Xaa Ser Ala Gly Xaa Pro Asp Glu Ala Ala Pro Leu Ala 
        275                 280                 285             


Glu Arg Xaa Pro Asp Xaa Ala Glu Ser Leu Val Glu Lys Xaa Pro Asp 
    290                 295                 300                 


Glu Ala Ala Pro Leu Val Glu Arg Xaa Pro Asp Xaa Ala Glu Ser Leu 
305                 310                 315                 320 


Val Glu Lys Xaa Pro Asp Glu Ala Ala Ser Leu Val Glu Gly Xaa Ser 
                325                 330                 335     


Asp Lys Ile Gln Cys Leu Glu Lys Ala Xaa Ser Gly Lys Phe Glu Gln 
            340                 345                 350         


Ser Ala Glu Glu Xaa Pro Arg Glu Ile Xaa Ser Pro Ala Lys Glu Xaa 
        355                 360                 365             


Ser Glu Lys Phe Xaa Trp Pro Ala Lys Gly Arg Pro Arg Lys Ile Ala 
    370                 375                 380                 


Trp Glu Lys Lys Glu Asp Xaa Pro Arg Glu Ile Met Ser Pro Ala Lys 
385                 390                 395                 400 


Glu Xaa Ser Glu Lys Phe Xaa Trp Ala Ala Lys Gly Arg Pro Arg Lys 
                405                 410                 415     


Ile Ala Trp Glu Lys Lys Glu Xaa Pro Val Lys Xaa Gly Cys Val Ala 
            420                 425                 430         


Arg Val Xaa Ser Asn Lys Xaa Lys Val Leu Glu Lys Gly Arg Ser Lys 
        435                 440                 445             


Met Ile Ala Cys Pro Xaa Lys Glu Ser Ser Xaa Lys Ala Ser Ala Asn 
    450                 455                 460                 


Asp Gln Arg Phe Pro Ser Glu Ser Lys Gln Glu Glu Asp Glu Glu Tyr 
465                 470                 475                 480 


Ser Cys Asp Ser Arg Ser Leu Phe Glu Ser Ser Ala Lys Ile Gln Val 
                485                 490                 495     


Cys Ile Pro Glu Ser Ile Tyr Gln Lys Val Met Glu Ile Asn Arg Glu 
            500                 505                 510         


Val Glu Glu Pro Pro Lys Lys Pro Ser Ala Phe Lys Pro Ala Ile Glu 
        515                 520                 525             


Met Gln Asn Ser Val Pro Asn Lys Ala Phe Glu Leu Lys Asn Glu Gln 
    530                 535                 540                 


Xaa Leu Arg Ala Asp Pro Met Phe Pro Pro Glu Ser Lys Gln Lys Asp 
545                 550                 555                 560 


Tyr Glu Glu Asn Ser Trp Asp Ser Glu Ser Leu Cys Glu Xaa Val Ser 
                565                 570                 575     


Gln Lys Asp Val Cys Leu Pro Lys Ala Xaa His Gln Lys Glu Ile Asp 
            580                 585                 590         


Lys Ile Asn Gly Lys Leu Glu Glu Ser Pro Asn Lys Asp Gly Leu Leu 
        595                 600                 605             


Lys Ala Xaa Cys Gly Met Lys Val Ser Ile Pro Xaa Lys Ala Leu Glu 
    610                 615                 620                 


Leu Lys Asp Met Gln Xaa Phe Lys Ala Glu Pro Pro Gly Lys Pro Ser 
625                 630                 635                 640 


Ala Phe Glu Pro Ala Xaa Glu Met Gln Lys Ser Val Pro Asn Lys Ala 
                645                 650                 655     


Leu Glu Leu Lys Asn Glu Gln Xaa Leu Arg Ala Asp Glu Ile Leu Pro 
            660                 665                 670         


Ser Glu Ser Lys Gln Lys Asp Tyr Glu Glu Asn Ser Trp Asp Xaa Glu 
        675                 680                 685             


Ser Leu Cys Glu Xaa Val Ser Gln Lys Asp Val Cys Leu Pro Lys Ala 
    690                 695                 700                 


Ala His Gln Lys Glu Ile Asp Lys Ile Asn Gly Lys Leu Glu Gly Ser 
705                 710                 715                 720 


Pro Val Lys Asp Gly Leu Leu Lys Ala Asn Cys Gly Met Lys Val Ser 
                725                 730                 735     


Ile Pro Xaa Lys Ala Leu Glu Leu Met Asp Met Gln Xaa Phe Lys Ala 
            740                 745                 750         


Glu Pro Pro Glu Lys Pro Ser Ala Phe Glu Pro Ala Ile Glu Met Gln 
        755                 760                 765             


Lys Ser Val Pro Asn Lys Ala Leu Glu Leu Lys Asn Glu Gln Xaa Leu 
    770                 775                 780                 


Arg Ala Asp Glu Ile Leu Pro Ser Glu Ser Lys Gln Lys Asp Tyr Glu 
785                 790                 795                 800 


Glu Ser Ser Trp Asp Ser Glu Ser Leu Cys Glu Xaa Val Ser Gln Lys 
                805                 810                 815     


Asp Val Cys Leu Pro Lys Ala Xaa His Gln Lys Glu Ile Asp Lys Ile 
            820                 825                 830         


Asn Gly Lys Leu Glu Glu Ser Pro Asp Asn Asp Gly Phe Leu Lys Ala 
        835                 840                 845             


Pro Cys Arg Met Lys Val Ser Ile Pro Xaa Lys Ala Leu Glu Leu Met 
    850                 855                 860                 


Asp Met Gln Xaa Phe Lys Ala Glu Pro Pro Glu Lys Pro Ser Ala Phe 
865                 870                 875                 880 


Glu Pro Ala Ile Glu Met Gln Lys Ser Val Pro Asn Lys Ala Leu Glu 
                885                 890                 895     


Leu Lys Asn Glu Gln Xaa Leu Arg Ala Asp Gln Met Phe Pro Ser Glu 
            900                 905                 910         


Ser Lys Gln Lys Lys Val Glu Glu Asn Ser Trp Asp Ser Glu Ser Leu 
        915                 920                 925             


Arg Glu Xaa Val Ser Gln Lys Asp Val Cys Val Pro Lys Ala Xaa His 
    930                 935                 940                 


Gln Lys Glu Met Asp Lys Ile Ser Gly Lys Leu Glu Asp Ser Xaa Ser 
945                 950                 955                 960 


Leu Ser Lys Ile Leu Asp Xaa Val His Ser Cys Glu Arg Ala Arg Glu 
                965                 970                 975     


Leu Gln Lys Asp His Cys Glu Gln Arg Xaa Gly Lys Met Glu Gln Met 
            980                 985                 990         


Lys Lys Lys Phe Cys Val Leu Lys  Lys Lys Leu Ser Glu  Ala Lys Glu 
        995                 1000                 1005             


Ile Lys  Ser Gln Leu Glu Asn  Gln Lys Val Lys Trp  Glu Gln Glu 
    1010                 1015                 1020             


Leu Cys  Ser Val Arg Leu Xaa  Leu Asn Gln Glu Glu  Glu Lys Arg 
    1025                 1030                 1035             


Arg Asn  Ala Asp Ile Leu Asn  Glu Lys Ile Arg Glu  Glu Leu Gly 
    1040                 1045                 1050             


Arg Ile  Glu Glu Gln His Arg  Lys Glu Leu Glu Val  Lys Gln Gln 
    1055                 1060                 1065             


Leu Glu  Gln Ala Leu Arg Ile  Gln Asp Ile Glu Leu  Lys Ser Val 
    1070                 1075                 1080             


Glu Ser  Asn Leu Asn Gln Val  Ser His Xaa His Glu  Asn Glu Asn 
    1085                 1090                 1095             


Tyr Leu  Leu His Glu Asn Cys  Met Leu Lys Lys Glu  Ile Ala Met 
    1100                 1105                 1110             


Leu Lys  Leu Glu Ile Ala Xaa  Leu Lys His Gln Tyr  Gln Glu Lys 
    1115                 1120                 1125             


Glu Asn  Lys Tyr Phe Glu Asp  Ile Lys Ile Leu Lys  Glu Lys Asn 
    1130                 1135                 1140             


Ala Glu  Leu Gln Met Xaa Leu  Lys Leu Lys Glu Glu  Ser Leu Xaa 
    1145                 1150                 1155             


Lys Arg  Ala Ser Gln Tyr Ser  Gly Gln Leu Lys Val  Leu Ile Ala 
    1160                 1165                 1170             


Glu Asn  Xaa Met Leu Xaa Ser  Lys Leu Lys Glu Lys  Gln Asp Lys 
    1175                 1180                 1185             


Glu Ile  Leu Glu Ala Glu Ile  Glu Ser His His Pro  Arg Leu Ala 
    1190                 1195                 1200             


Ser Ala  Val Gln Asp His Asp  Gln Ile Val Xaa Ser  Arg Lys Ser 
    1205                 1210                 1215             


Gln Glu  Pro Ala Phe His Ile  Ala Gly Asp Ala Cys  Leu Gln Arg 
    1220                 1225                 1230             


Lys Met  Asn Val Asp Val Ser  Ser Xaa Ile Tyr Asn  Asn Glu Val 
    1235                 1240                 1245             


Leu His  Gln Pro Leu Ser Glu  Ala Gln Arg Lys Ser  Lys Ser Leu 
    1250                 1255                 1260             


Lys Ile  Asn Leu Asn Tyr Ala  Gly Asp Ala Leu Arg  Glu Asn Xaa 
    1265                 1270                 1275             


Leu Val  Ser Glu His Ala Gln  Arg Asp Gln Arg Glu  Xaa Gln Cys 
    1280                 1285                 1290             


Gln Met  Lys Glu Ala Glu His  Met Tyr Gln Asn Glu  Gln Asp Asn 
    1295                 1300                 1305             


Val Asn  Lys His Xaa Glu Gln  Gln Glu Ser Leu Asp  Gln Lys Leu 
    1310                 1315                 1320             


Phe Gln  Leu Gln Ser Lys Asn  Met Trp Leu Gln Gln  Gln Leu Val 
    1325                 1330                 1335             


His Ala  His Lys Lys Ala Asp  Asn Lys Ser Lys Ile  Xaa Ile Asp 
    1340                 1345                 1350             


Ile His  Phe Leu Glu Arg Lys  Met Gln His His Leu  Leu Lys Glu 
    1355                 1360                 1365             


Lys Asn  Glu Glu Ile Phe Asn  Tyr Asn Asn His Leu  Lys Asn Arg 
    1370                 1375                 1380             


Ile Tyr  Gln Tyr Glu Lys Glu  Lys Ala Glu Xaa Glu  Asn Ser 
    1385                 1390                 1395         


<210> 2366
<211> 1341
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1093)..(1093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1120)..(1120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1123)..(1123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1222)..(1222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1235)..(1235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1338)..(1338)
<223> Selenocysteine

<400> 2366
Met Xaa Lys Arg Lys Lys Xaa Ile Asn Leu Asn Ile Gln Asp Ala Gln 
1               5                   10                  15      


Lys Arg Xaa Ala Leu His Trp Ala Cys Val Asn Gly His Glu Glu Val 
            20                  25                  30          


Val Xaa Phe Leu Val Asp Arg Lys Cys Gln Leu Asp Val Leu Asp Gly 
        35                  40                  45              


Glu His Arg Xaa Pro Leu Met Lys Ala Leu Gln Cys His Gln Glu Ala 
    50                  55                  60                  


Cys Ala Asn Ile Leu Ile Asp Ser Gly Ala Asp Ile Asn Leu Val Asp 
65                  70                  75                  80  


Val Tyr Gly Asn Xaa Ala Leu His Tyr Ala Val Tyr Ser Glu Ile Leu 
                85                  90                  95      


Ser Val Val Ala Lys Leu Leu Ser His Gly Ala Val Ile Glu Val His 
            100                 105                 110         


Asn Lys Ala Ser Leu Xaa Pro Leu Leu Leu Ser Ile Xaa Lys Arg Ser 
        115                 120                 125             


Glu Gln Ile Val Glu Phe Leu Leu Ile Lys Asn Ala Asn Ala Asn Ala 
    130                 135                 140                 


Val Asn Lys Tyr Lys Cys Xaa Ala Leu Met Leu Ala Val Cys His Gly 
145                 150                 155                 160 


Ser Ser Glu Ile Val Gly Met Leu Leu Gln Gln Asn Val Asp Val Phe 
                165                 170                 175     


Ala Ala Asp Ile Cys Gly Val Xaa Ala Glu His Tyr Ala Val Xaa Cys 
            180                 185                 190         


Gly Phe His His Ile His Glu Gln Ile Met Glu Tyr Ile Arg Lys Leu 
        195                 200                 205             


Ser Lys Asn His Gln Asn Xaa Asn Pro Glu Gly Xaa Ser Ala Gly Xaa 
    210                 215                 220                 


Pro Asp Glu Ala Ala Pro Leu Ala Glu Arg Xaa Pro Asp Xaa Ala Glu 
225                 230                 235                 240 


Ser Leu Val Glu Lys Xaa Pro Asp Glu Ala Ala Pro Leu Val Glu Arg 
                245                 250                 255     


Xaa Pro Asp Xaa Ala Glu Ser Leu Val Glu Lys Xaa Pro Asp Glu Ala 
            260                 265                 270         


Ala Ser Leu Val Glu Gly Xaa Ser Asp Lys Ile Gln Cys Leu Glu Lys 
        275                 280                 285             


Ala Xaa Ser Gly Lys Phe Glu Gln Ser Ala Glu Glu Xaa Pro Arg Glu 
    290                 295                 300                 


Ile Xaa Ser Pro Ala Lys Glu Xaa Ser Glu Lys Phe Xaa Trp Pro Ala 
305                 310                 315                 320 


Lys Gly Arg Pro Arg Lys Ile Ala Trp Glu Lys Lys Glu Asp Xaa Pro 
                325                 330                 335     


Arg Glu Ile Met Ser Pro Ala Lys Glu Xaa Ser Glu Lys Phe Xaa Trp 
            340                 345                 350         


Ala Ala Lys Gly Arg Pro Arg Lys Ile Ala Trp Glu Lys Lys Glu Xaa 
        355                 360                 365             


Pro Val Lys Xaa Gly Cys Val Ala Arg Val Xaa Ser Asn Lys Xaa Lys 
    370                 375                 380                 


Val Leu Glu Lys Gly Arg Ser Lys Met Ile Ala Cys Pro Xaa Lys Glu 
385                 390                 395                 400 


Ser Ser Xaa Lys Ala Ser Ala Asn Asp Gln Arg Phe Pro Ser Glu Ser 
                405                 410                 415     


Lys Gln Glu Glu Asp Glu Glu Tyr Ser Cys Asp Ser Arg Ser Leu Phe 
            420                 425                 430         


Glu Ser Ser Ala Lys Ile Gln Val Cys Ile Pro Glu Ser Ile Tyr Gln 
        435                 440                 445             


Lys Val Met Glu Ile Asn Arg Glu Val Glu Glu Pro Pro Lys Lys Pro 
    450                 455                 460                 


Ser Ala Phe Lys Pro Ala Ile Glu Met Gln Asn Ser Val Pro Asn Lys 
465                 470                 475                 480 


Ala Phe Glu Leu Lys Asn Glu Gln Xaa Leu Arg Ala Asp Pro Met Phe 
                485                 490                 495     


Pro Pro Glu Ser Lys Gln Lys Asp Tyr Glu Glu Asn Ser Trp Asp Ser 
            500                 505                 510         


Glu Ser Leu Cys Glu Xaa Val Ser Gln Lys Asp Val Cys Leu Pro Lys 
        515                 520                 525             


Ala Xaa His Gln Lys Glu Ile Asp Lys Ile Asn Gly Lys Leu Glu Glu 
    530                 535                 540                 


Ser Pro Asn Lys Asp Gly Leu Leu Lys Ala Xaa Cys Gly Met Lys Val 
545                 550                 555                 560 


Ser Ile Pro Xaa Lys Ala Leu Glu Leu Lys Asp Met Gln Xaa Phe Lys 
                565                 570                 575     


Ala Glu Pro Pro Gly Lys Pro Ser Ala Phe Glu Pro Ala Xaa Glu Met 
            580                 585                 590         


Gln Lys Ser Val Pro Asn Lys Ala Leu Glu Leu Lys Asn Glu Gln Xaa 
        595                 600                 605             


Leu Arg Ala Asp Glu Ile Leu Pro Ser Glu Ser Lys Gln Lys Asp Tyr 
    610                 615                 620                 


Glu Glu Asn Ser Trp Asp Xaa Glu Ser Leu Cys Glu Xaa Val Ser Gln 
625                 630                 635                 640 


Lys Asp Val Cys Leu Pro Lys Ala Ala His Gln Lys Glu Ile Asp Lys 
                645                 650                 655     


Ile Asn Gly Lys Leu Glu Gly Ser Pro Val Lys Asp Gly Leu Leu Lys 
            660                 665                 670         


Ala Asn Cys Gly Met Lys Val Ser Ile Pro Xaa Lys Ala Leu Glu Leu 
        675                 680                 685             


Met Asp Met Gln Xaa Phe Lys Ala Glu Pro Pro Glu Lys Pro Ser Ala 
    690                 695                 700                 


Phe Glu Pro Ala Ile Glu Met Gln Lys Ser Val Pro Asn Lys Ala Leu 
705                 710                 715                 720 


Glu Leu Lys Asn Glu Gln Xaa Leu Arg Ala Asp Glu Ile Leu Pro Ser 
                725                 730                 735     


Glu Ser Lys Gln Lys Asp Tyr Glu Glu Ser Ser Trp Asp Ser Glu Ser 
            740                 745                 750         


Leu Cys Glu Xaa Val Ser Gln Lys Asp Val Cys Leu Pro Lys Ala Xaa 
        755                 760                 765             


His Gln Lys Glu Ile Asp Lys Ile Asn Gly Lys Leu Glu Glu Ser Pro 
    770                 775                 780                 


Asp Asn Asp Gly Phe Leu Lys Ala Pro Cys Arg Met Lys Val Ser Ile 
785                 790                 795                 800 


Pro Xaa Lys Ala Leu Glu Leu Met Asp Met Gln Xaa Phe Lys Ala Glu 
                805                 810                 815     


Pro Pro Glu Lys Pro Ser Ala Phe Glu Pro Ala Ile Glu Met Gln Lys 
            820                 825                 830         


Ser Val Pro Asn Lys Ala Leu Glu Leu Lys Asn Glu Gln Xaa Leu Arg 
        835                 840                 845             


Ala Asp Gln Met Phe Pro Ser Glu Ser Lys Gln Lys Lys Val Glu Glu 
    850                 855                 860                 


Asn Ser Trp Asp Ser Glu Ser Leu Arg Glu Xaa Val Ser Gln Lys Asp 
865                 870                 875                 880 


Val Cys Val Pro Lys Ala Xaa His Gln Lys Glu Met Asp Lys Ile Ser 
                885                 890                 895     


Gly Lys Leu Glu Asp Ser Xaa Ser Leu Ser Lys Ile Leu Asp Xaa Val 
            900                 905                 910         


His Ser Cys Glu Arg Ala Arg Glu Leu Gln Lys Asp His Cys Glu Gln 
        915                 920                 925             


Arg Xaa Gly Lys Met Glu Gln Met Lys Lys Lys Phe Cys Val Leu Lys 
    930                 935                 940                 


Lys Lys Leu Ser Glu Ala Lys Glu Ile Lys Ser Gln Leu Glu Asn Gln 
945                 950                 955                 960 


Lys Val Lys Trp Glu Gln Glu Leu Cys Ser Val Arg Leu Xaa Leu Asn 
                965                 970                 975     


Gln Glu Glu Glu Lys Arg Arg Asn Ala Asp Ile Leu Asn Glu Lys Ile 
            980                 985                 990         


Arg Glu Glu Leu Gly Arg Ile Glu  Glu Gln His Arg Lys  Glu Leu Glu 
        995                 1000                 1005             


Val Lys  Gln Gln Leu Glu Gln  Ala Leu Arg Ile Gln  Asp Ile Glu 
    1010                 1015                 1020             


Leu Lys  Ser Val Glu Ser Asn  Leu Asn Gln Val Ser  His Xaa His 
    1025                 1030                 1035             


Glu Asn  Glu Asn Tyr Leu Leu  His Glu Asn Cys Met  Leu Lys Lys 
    1040                 1045                 1050             


Glu Ile  Ala Met Leu Lys Leu  Glu Ile Ala Xaa Leu  Lys His Gln 
    1055                 1060                 1065             


Tyr Gln  Glu Lys Glu Asn Lys  Tyr Phe Glu Asp Ile  Lys Ile Leu 
    1070                 1075                 1080             


Lys Glu  Lys Asn Ala Glu Leu  Gln Met Xaa Leu Lys  Leu Lys Glu 
    1085                 1090                 1095             


Glu Ser  Leu Xaa Lys Arg Ala  Ser Gln Tyr Ser Gly  Gln Leu Lys 
    1100                 1105                 1110             


Val Leu  Ile Ala Glu Asn Xaa  Met Leu Xaa Ser Lys  Leu Lys Glu 
    1115                 1120                 1125             


Lys Gln  Asp Lys Glu Ile Leu  Glu Ala Glu Ile Glu  Ser His His 
    1130                 1135                 1140             


Pro Arg  Leu Ala Ser Ala Val  Gln Asp His Asp Gln  Ile Val Xaa 
    1145                 1150                 1155             


Ser Arg  Lys Ser Gln Glu Pro  Ala Phe His Ile Ala  Gly Asp Ala 
    1160                 1165                 1170             


Cys Leu  Gln Arg Lys Met Asn  Val Asp Val Ser Ser  Xaa Ile Tyr 
    1175                 1180                 1185             


Asn Asn  Glu Val Leu His Gln  Pro Leu Ser Glu Ala  Gln Arg Lys 
    1190                 1195                 1200             


Ser Lys  Ser Leu Lys Ile Asn  Leu Asn Tyr Ala Gly  Asp Ala Leu 
    1205                 1210                 1215             


Arg Glu  Asn Xaa Leu Val Ser  Glu His Ala Gln Arg  Asp Gln Arg 
    1220                 1225                 1230             


Glu Xaa  Gln Cys Gln Met Lys  Glu Ala Glu His Met  Tyr Gln Asn 
    1235                 1240                 1245             


Glu Gln  Asp Asn Val Asn Lys  His Xaa Glu Gln Gln  Glu Ser Leu 
    1250                 1255                 1260             


Asp Gln  Lys Leu Phe Gln Leu  Gln Ser Lys Asn Met  Trp Leu Gln 
    1265                 1270                 1275             


Gln Gln  Leu Val His Ala His  Lys Lys Ala Asp Asn  Lys Ser Lys 
    1280                 1285                 1290             


Ile Xaa  Ile Asp Ile His Phe  Leu Glu Arg Lys Met  Gln His His 
    1295                 1300                 1305             


Leu Leu  Lys Glu Lys Asn Glu  Glu Ile Phe Asn Tyr  Asn Asn His 
    1310                 1315                 1320             


Leu Lys  Asn Arg Ile Tyr Gln  Tyr Glu Lys Glu Lys  Ala Glu Xaa 
    1325                 1330                 1335             


Glu Asn  Ser 
    1340     


<210> 2367
<211> 1460
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1093)..(1093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1221)..(1221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1277)..(1277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1354)..(1354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1457)
<223> Selenocysteine

<400> 2367
Met Xaa Lys Arg Lys Lys Xaa Ile Asn Leu Asn Ile Gln Asp Ala Gln 
1               5                   10                  15      


Lys Arg Xaa Ala Leu His Trp Ala Cys Val Asn Gly His Glu Glu Val 
            20                  25                  30          


Val Xaa Phe Leu Val Asp Arg Lys Cys Gln Leu Asp Val Leu Asp Gly 
        35                  40                  45              


Glu His Arg Xaa Pro Leu Met Lys Ala Leu Gln Cys His Gln Glu Ala 
    50                  55                  60                  


Cys Ala Asn Ile Leu Ile Asp Ser Gly Ala Asp Ile Asn Leu Val Asp 
65                  70                  75                  80  


Val Tyr Gly Asn Xaa Ala Leu His Tyr Ala Val Tyr Ser Glu Ile Leu 
                85                  90                  95      


Ser Val Val Ala Lys Leu Leu Ser His Gly Ala Val Ile Glu Val His 
            100                 105                 110         


Asn Lys Ala Ser Leu Xaa Pro Leu Leu Leu Ser Ile Xaa Lys Arg Ser 
        115                 120                 125             


Glu Gln Ile Val Glu Phe Leu Leu Ile Lys Asn Ala Asn Ala Asn Ala 
    130                 135                 140                 


Val Asn Lys Tyr Lys Cys Xaa Ala Leu Met Leu Ala Val Cys His Gly 
145                 150                 155                 160 


Ser Ser Glu Ile Val Gly Met Leu Leu Gln Gln Asn Val Asp Val Phe 
                165                 170                 175     


Ala Ala Asp Ile Cys Gly Val Xaa Ala Glu His Tyr Ala Val Xaa Cys 
            180                 185                 190         


Gly Phe His His Ile His Glu Gln Ile Met Glu Tyr Ile Arg Lys Leu 
        195                 200                 205             


Ser Lys Asn His Gln Asn Xaa Asn Pro Glu Gly Xaa Ser Ala Gly Xaa 
    210                 215                 220                 


Pro Asp Glu Ala Ala Pro Leu Ala Glu Arg Xaa Pro Asp Xaa Ala Glu 
225                 230                 235                 240 


Ser Leu Val Glu Lys Xaa Pro Asp Glu Ala Ala Pro Leu Val Glu Arg 
                245                 250                 255     


Xaa Pro Asp Xaa Ala Glu Ser Leu Val Glu Lys Xaa Pro Asp Glu Ala 
            260                 265                 270         


Ala Ser Leu Val Glu Gly Xaa Ser Asp Lys Ile Gln Cys Leu Glu Lys 
        275                 280                 285             


Ala Xaa Ser Gly Lys Phe Glu Gln Ser Ala Glu Glu Xaa Pro Arg Glu 
    290                 295                 300                 


Ile Xaa Ser Pro Ala Lys Glu Xaa Ser Glu Lys Phe Xaa Trp Pro Ala 
305                 310                 315                 320 


Lys Gly Arg Pro Arg Lys Ile Ala Trp Glu Lys Lys Glu Asp Xaa Pro 
                325                 330                 335     


Arg Glu Ile Met Ser Pro Ala Lys Glu Xaa Ser Glu Lys Phe Xaa Trp 
            340                 345                 350         


Ala Ala Lys Gly Arg Pro Arg Lys Ile Ala Trp Glu Lys Lys Glu Xaa 
        355                 360                 365             


Pro Val Lys Xaa Gly Cys Val Ala Arg Val Xaa Ser Asn Lys Xaa Lys 
    370                 375                 380                 


Val Leu Glu Lys Gly Arg Ser Lys Met Ile Ala Cys Pro Xaa Lys Glu 
385                 390                 395                 400 


Ser Ser Xaa Lys Ala Ser Ala Asn Asp Gln Arg Phe Pro Ser Glu Ser 
                405                 410                 415     


Lys Gln Glu Glu Asp Glu Glu Tyr Ser Cys Asp Ser Arg Ser Leu Phe 
            420                 425                 430         


Glu Ser Ser Ala Lys Ile Gln Val Cys Ile Pro Glu Ser Ile Tyr Gln 
        435                 440                 445             


Lys Val Met Glu Ile Asn Arg Glu Val Glu Glu Pro Pro Lys Lys Pro 
    450                 455                 460                 


Ser Ala Phe Lys Pro Ala Ile Glu Met Gln Asn Ser Val Pro Asn Lys 
465                 470                 475                 480 


Ala Phe Glu Leu Lys Asn Glu Gln Xaa Leu Arg Ala Asp Pro Met Phe 
                485                 490                 495     


Pro Pro Glu Ser Lys Gln Lys Asp Tyr Glu Glu Asn Ser Trp Asp Ser 
            500                 505                 510         


Glu Ser Leu Cys Glu Xaa Val Ser Gln Lys Asp Val Cys Leu Pro Lys 
        515                 520                 525             


Ala Xaa His Gln Lys Glu Ile Asp Lys Ile Asn Gly Lys Leu Glu Glu 
    530                 535                 540                 


Ser Pro Asn Lys Asp Gly Leu Leu Lys Ala Xaa Cys Gly Met Lys Val 
545                 550                 555                 560 


Ser Ile Pro Xaa Lys Ala Leu Glu Leu Lys Asp Met Gln Xaa Phe Lys 
                565                 570                 575     


Ala Glu Pro Pro Gly Lys Pro Ser Ala Phe Glu Pro Ala Xaa Glu Met 
            580                 585                 590         


Gln Lys Ser Val Pro Asn Lys Ala Leu Glu Leu Lys Asn Glu Gln Xaa 
        595                 600                 605             


Leu Arg Ala Asp Glu Ile Leu Pro Ser Glu Ser Lys Gln Lys Asp Tyr 
    610                 615                 620                 


Glu Glu Asn Ser Trp Asp Xaa Glu Ser Leu Cys Glu Xaa Val Ser Gln 
625                 630                 635                 640 


Lys Asp Val Cys Leu Pro Lys Ala Ala His Gln Lys Glu Ile Asp Lys 
                645                 650                 655     


Ile Asn Gly Lys Leu Glu Gly Ser Pro Val Lys Asp Gly Leu Leu Lys 
            660                 665                 670         


Ala Asn Cys Gly Met Lys Val Ser Ile Pro Xaa Lys Ala Leu Glu Leu 
        675                 680                 685             


Met Asp Met Gln Xaa Phe Lys Ala Glu Pro Pro Glu Lys Pro Ser Ala 
    690                 695                 700                 


Phe Glu Pro Ala Ile Glu Met Gln Lys Ser Val Pro Asn Lys Ala Leu 
705                 710                 715                 720 


Glu Leu Lys Asn Glu Gln Xaa Leu Arg Ala Asp Glu Ile Leu Pro Ser 
                725                 730                 735     


Glu Ser Lys Gln Lys Asp Tyr Glu Glu Ser Ser Trp Asp Ser Glu Ser 
            740                 745                 750         


Leu Cys Glu Xaa Val Ser Gln Lys Asp Val Cys Leu Pro Lys Ala Ala 
        755                 760                 765             


His Gln Lys Glu Ile Asp Lys Ile Asn Gly Lys Leu Glu Gly Ser Pro 
    770                 775                 780                 


Val Lys Asp Gly Leu Leu Lys Ala Asn Cys Gly Met Lys Val Ser Ile 
785                 790                 795                 800 


Pro Xaa Lys Ala Leu Glu Leu Met Asp Met Gln Xaa Phe Lys Ala Glu 
                805                 810                 815     


Pro Pro Glu Lys Pro Ser Ala Phe Glu Pro Ala Ile Glu Met Gln Lys 
            820                 825                 830         


Ser Val Pro Asn Lys Ala Leu Glu Leu Lys Asn Glu Gln Xaa Leu Arg 
        835                 840                 845             


Ala Asp Glu Ile Leu Pro Ser Glu Ser Lys Gln Lys Asp Tyr Glu Glu 
    850                 855                 860                 


Ser Ser Trp Asp Ser Glu Ser Leu Cys Glu Xaa Val Ser Gln Lys Asp 
865                 870                 875                 880 


Val Cys Leu Pro Lys Ala Xaa His Gln Lys Glu Ile Asp Lys Ile Asn 
                885                 890                 895     


Gly Lys Leu Glu Glu Ser Pro Asp Asn Asp Gly Phe Leu Lys Ala Pro 
            900                 905                 910         


Cys Arg Met Lys Val Ser Ile Pro Xaa Lys Ala Leu Glu Leu Met Asp 
        915                 920                 925             


Met Gln Xaa Phe Lys Ala Glu Pro Pro Glu Lys Pro Ser Ala Phe Glu 
    930                 935                 940                 


Pro Ala Ile Glu Met Gln Lys Ser Val Pro Asn Lys Ala Leu Glu Leu 
945                 950                 955                 960 


Lys Asn Glu Gln Xaa Leu Arg Ala Asp Gln Met Phe Pro Ser Glu Ser 
                965                 970                 975     


Lys Gln Lys Lys Val Glu Glu Asn Ser Trp Asp Ser Glu Ser Leu Arg 
            980                 985                 990         


Glu Xaa Val Ser Gln Lys Asp Val  Cys Val Pro Lys Ala  Xaa His Gln 
        995                 1000                 1005             


Lys Glu  Met Asp Lys Ile Ser  Gly Lys Leu Glu Asp  Ser Xaa Ser 
    1010                 1015                 1020             


Leu Ser  Lys Ile Leu Asp Xaa  Val His Ser Cys Glu  Arg Ala Arg 
    1025                 1030                 1035             


Glu Leu  Gln Lys Asp His Cys  Glu Gln Arg Xaa Gly  Lys Met Glu 
    1040                 1045                 1050             


Gln Met  Lys Lys Lys Phe Cys  Val Leu Lys Lys Lys  Leu Ser Glu 
    1055                 1060                 1065             


Ala Lys  Glu Ile Lys Ser Gln  Leu Glu Asn Gln Lys  Val Lys Trp 
    1070                 1075                 1080             


Glu Gln  Glu Leu Cys Ser Val  Arg Leu Xaa Leu Asn  Gln Glu Glu 
    1085                 1090                 1095             


Glu Lys  Arg Arg Asn Ala Asp  Ile Leu Asn Glu Lys  Ile Arg Glu 
    1100                 1105                 1110             


Glu Leu  Gly Arg Ile Glu Glu  Gln His Arg Lys Glu  Leu Glu Val 
    1115                 1120                 1125             


Lys Gln  Gln Leu Glu Gln Ala  Leu Arg Ile Gln Asp  Ile Glu Leu 
    1130                 1135                 1140             


Lys Ser  Val Glu Ser Asn Leu  Asn Gln Val Ser His  Xaa His Glu 
    1145                 1150                 1155             


Asn Glu  Asn Tyr Leu Leu His  Glu Asn Cys Met Leu  Lys Lys Glu 
    1160                 1165                 1170             


Ile Ala  Met Leu Lys Leu Glu  Ile Ala Xaa Leu Lys  His Gln Tyr 
    1175                 1180                 1185             


Gln Glu  Lys Glu Asn Lys Tyr  Phe Glu Asp Ile Lys  Ile Leu Lys 
    1190                 1195                 1200             


Glu Lys  Asn Ala Glu Leu Gln  Met Xaa Leu Lys Leu  Lys Glu Glu 
    1205                 1210                 1215             


Ser Leu  Xaa Lys Arg Ala Ser  Gln Tyr Ser Gly Gln  Leu Lys Val 
    1220                 1225                 1230             


Leu Ile  Ala Glu Asn Xaa Met  Leu Xaa Ser Lys Leu  Lys Glu Lys 
    1235                 1240                 1245             


Gln Asp  Lys Glu Ile Leu Glu  Ala Glu Ile Glu Ser  His His Pro 
    1250                 1255                 1260             


Arg Leu  Ala Ser Ala Val Gln  Asp His Asp Gln Ile  Val Xaa Ser 
    1265                 1270                 1275             


Arg Lys  Ser Gln Glu Pro Ala  Phe His Ile Ala Gly  Asp Ala Cys 
    1280                 1285                 1290             


Leu Gln  Arg Lys Met Asn Val  Asp Val Ser Ser Xaa  Ile Tyr Asn 
    1295                 1300                 1305             


Asn Glu  Val Leu His Gln Pro  Leu Ser Glu Ala Gln  Arg Lys Ser 
    1310                 1315                 1320             


Lys Ser  Leu Lys Ile Asn Leu  Asn Tyr Ala Gly Asp  Ala Leu Arg 
    1325                 1330                 1335             


Glu Asn  Xaa Leu Val Ser Glu  His Ala Gln Arg Asp  Gln Arg Glu 
    1340                 1345                 1350             


Xaa Gln  Cys Gln Met Lys Glu  Ala Glu His Met Tyr  Gln Asn Glu 
    1355                 1360                 1365             


Gln Asp  Asn Val Asn Lys His  Xaa Glu Gln Gln Glu  Ser Leu Asp 
    1370                 1375                 1380             


Gln Lys  Leu Phe Gln Leu Gln  Ser Lys Asn Met Trp  Leu Gln Gln 
    1385                 1390                 1395             


Gln Leu  Val His Ala His Lys  Lys Ala Asp Asn Lys  Ser Lys Ile 
    1400                 1405                 1410             


Xaa Ile  Asp Ile His Phe Leu  Glu Arg Lys Met Gln  His His Leu 
    1415                 1420                 1425             


Leu Lys  Glu Lys Asn Glu Glu  Ile Phe Asn Tyr Asn  Asn His Leu 
    1430                 1435                 1440             


Lys Asn  Arg Ile Tyr Gln Tyr  Glu Lys Glu Lys Ala  Glu Xaa Glu 
    1445                 1450                 1455             


Asn Ser  
    1460 


<210> 2368
<211> 217
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<400> 2368
Met Ala Ala Ala Ala Gly Asp Ala Asp Asp Glu Pro Arg Ser Gly His 
1               5                   10                  15      


Ser Ser Ser Glu Gly Glu Cys Ala Val Ala Pro Glu Pro Leu Xaa Asp 
            20                  25                  30          


Ala Glu Gly Leu Phe Ser Phe Ala Asp Phe Gly Ser Ala Leu Gly Gly 
        35                  40                  45              


Gly Gly Ala Gly Leu Ser Gly Arg Ala Ser Gly Gly Ala Gln Ser Pro 
    50                  55                  60                  


Leu Arg Tyr Leu His Val Leu Trp Gln Gln Asp Ala Glu Pro Arg Asp 
65                  70                  75                  80  


Glu Leu Arg Cys Lys Ile Pro Ala Gly Arg Leu Arg Arg Ala Ala Arg 
                85                  90                  95      


Pro His Arg Arg Leu Gly Pro Xaa Gly Lys Glu Val His Ala Leu Lys 
            100                 105                 110         


Arg Leu Arg Asp Ser Ala Asn Ala Asn Asp Val Glu Xaa Val Gln Gln 
        115                 120                 125             


Leu Leu Glu Asp Gly Ala Asp Pro Cys Ala Ala Asp Asp Lys Gly Arg 
    130                 135                 140                 


Xaa Ala Leu His Phe Ala Ser Cys Asn Gly Asn Asp Gln Ile Val Gln 
145                 150                 155                 160 


Leu Leu Leu Asp His Gly Ala Asp Pro Asn Gln Arg Asp Gly Leu Gly 
                165                 170                 175     


Asn Xaa Pro Leu His Leu Ala Ala Cys Xaa Asn His Val Pro Val Ile 
            180                 185                 190         


Xaa Xaa Leu Leu Arg Gly Ala Gly Xaa Cys Arg Gly Pro Cys Arg Cys 
        195                 200                 205             


Pro Gly Pro Ser Trp Ser His Xaa Pro 
    210                 215         


<210> 2369
<211> 300
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<400> 2369
Met Ala Ala Ala Ala Gly Asp Ala Asp Asp Glu Pro Arg Ser Gly His 
1               5                   10                  15      


Ser Ser Ser Glu Gly Glu Cys Ala Val Ala Pro Glu Pro Leu Xaa Asp 
            20                  25                  30          


Ala Glu Gly Leu Phe Ser Phe Ala Asp Phe Gly Ser Ala Leu Gly Gly 
        35                  40                  45              


Gly Gly Ala Gly Leu Ser Gly Arg Ala Ser Gly Gly Ala Gln Ser Pro 
    50                  55                  60                  


Leu Arg Tyr Leu His Val Leu Trp Gln Gln Asp Ala Glu Pro Arg Asp 
65                  70                  75                  80  


Glu Leu Arg Cys Lys Ile Pro Ala Gly Arg Leu Arg Arg Ala Ala Arg 
                85                  90                  95      


Pro His Arg Arg Leu Gly Pro Xaa Gly Lys Glu Val His Ala Leu Lys 
            100                 105                 110         


Arg Leu Arg Asp Ser Ala Asn Ala Asn Asp Val Glu Xaa Val Gln Gln 
        115                 120                 125             


Leu Leu Glu Asp Gly Ala Asp Pro Cys Ala Ala Asp Asp Lys Gly Arg 
    130                 135                 140                 


Xaa Ala Leu His Phe Ala Ser Cys Asn Gly Asn Asp Gln Ile Val Gln 
145                 150                 155                 160 


Leu Leu Leu Asp His Gly Ala Asp Pro Asn Gln Arg Asp Gly Leu Gly 
                165                 170                 175     


Asn Xaa Pro Leu His Leu Ala Ala Cys Xaa Asn His Val Pro Val Ile 
            180                 185                 190         


Xaa Xaa Leu Leu Arg Gly Gly Ala Arg Val Asp Ala Leu Asp Arg Ala 
        195                 200                 205             


Gly Arg Xaa Pro Leu His Leu Ala Lys Ser Lys Leu Asn Ile Leu Gln 
    210                 215                 220                 


Glu Gly His Ala Gln Cys Leu Glu Ala Val Arg Leu Glu Val Lys Gln 
225                 230                 235                 240 


Ile Ile His Met Leu Arg Glu Tyr Leu Glu Arg Leu Gly Gln His Glu 
                245                 250                 255     


Gln Arg Glu Arg Leu Asp Asp Leu Cys Xaa Arg Leu Gln Met Xaa Ser 
            260                 265                 270         


Xaa Lys Glu Gln Val Asp Glu Val Xaa Asp Leu Leu Ala Ser Phe Xaa 
        275                 280                 285             


Ser Leu Ser Leu Gln Met Gln Ser Met Glu Lys Arg 
    290                 295                 300 


<210> 2370
<211> 284
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<400> 2370
Met Ala Ala Ala Ala Gly Asp Ala Asp Asp Glu Pro Arg Ser Gly His 
1               5                   10                  15      


Ser Ser Ser Glu Gly Glu Cys Ala Val Ala Pro Glu Pro Leu Xaa Asp 
            20                  25                  30          


Ala Glu Gly Leu Phe Ser Phe Ala Asp Phe Gly Ser Ala Leu Gly Gly 
        35                  40                  45              


Gly Gly Ala Gly Leu Ser Gly Arg Ala Ser Gly Gly Ala Gln Ser Pro 
    50                  55                  60                  


Leu Arg Tyr Leu His Val Leu Trp Gln Gln Asp Ala Glu Pro Arg Asp 
65                  70                  75                  80  


Glu Leu Arg Cys Lys Ile Pro Ala Gly Arg Leu Arg Arg Ala Ala Arg 
                85                  90                  95      


Pro His Arg Arg Leu Gly Pro Xaa Gly Lys Glu Val His Val Gln Gln 
            100                 105                 110         


Leu Leu Glu Asp Gly Ala Asp Pro Cys Ala Ala Asp Asp Lys Gly Arg 
        115                 120                 125             


Xaa Ala Leu His Phe Ala Ser Cys Asn Gly Asn Asp Gln Ile Val Gln 
    130                 135                 140                 


Leu Leu Leu Asp His Gly Ala Asp Pro Asn Gln Arg Asp Gly Leu Gly 
145                 150                 155                 160 


Asn Xaa Pro Leu His Leu Ala Ala Cys Xaa Asn His Val Pro Val Ile 
                165                 170                 175     


Xaa Xaa Leu Leu Arg Gly Gly Ala Arg Val Asp Ala Leu Asp Arg Ala 
            180                 185                 190         


Gly Arg Xaa Pro Leu His Leu Ala Lys Ser Lys Leu Asn Ile Leu Gln 
        195                 200                 205             


Glu Gly His Ala Gln Cys Leu Glu Ala Val Arg Leu Glu Val Lys Gln 
    210                 215                 220                 


Ile Ile His Met Leu Arg Glu Tyr Leu Glu Arg Leu Gly Gln His Glu 
225                 230                 235                 240 


Gln Arg Glu Arg Leu Asp Asp Leu Cys Xaa Arg Leu Gln Met Xaa Ser 
                245                 250                 255     


Xaa Lys Glu Gln Val Asp Glu Val Xaa Asp Leu Leu Ala Ser Phe Xaa 
            260                 265                 270         


Ser Leu Ser Leu Gln Met Gln Ser Met Glu Lys Arg 
        275                 280                 


<210> 2371
<211> 90
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 2371
Met Ala Arg Ile Pro Val Gln Leu Met Xaa Arg Ala Ala Gln Leu Tyr 
1               5                   10                  15      


Xaa Leu Pro His Ala Met Ala Met Xaa Arg Leu Leu Leu Leu Asp His 
            20                  25                  30          


Gly Ala Asp Pro Asn Gln Arg Asp Gly Leu Gly Asn Xaa Pro Leu His 
        35                  40                  45              


Leu Ala Ala Cys Xaa Asn His Val Pro Val Ile Xaa Xaa Leu Leu Arg 
    50                  55                  60                  


Gly Gly Ala Arg Val Asp Ala Leu Asp Arg Ala Gly Arg Xaa Pro Leu 
65                  70                  75                  80  


His Leu Ala Lys Ser Lys Leu Asn Ile Leu 
                85                  90  


<210> 2372
<211> 156
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<400> 2372
Met Ala Arg Ile Pro Val Gln Leu Met Xaa Arg Ala Ala Gln Leu Tyr 
1               5                   10                  15      


Xaa Leu Pro His Ala Met Ala Met Xaa Arg Leu Leu Leu Leu Asp His 
            20                  25                  30          


Gly Ala Asp Pro Asn Gln Arg Asp Gly Leu Gly Asn Xaa Pro Leu His 
        35                  40                  45              


Leu Ala Ala Cys Xaa Asn His Val Pro Val Ile Xaa Xaa Leu Leu Arg 
    50                  55                  60                  


Gly Gly Ala Arg Val Asp Ala Leu Asp Arg Ala Gly Arg Xaa Pro Leu 
65                  70                  75                  80  


His Leu Ala Lys Ser Lys Leu Asn Ile Leu Gln Glu Gly His Ala Gln 
                85                  90                  95      


Cys Leu Glu Ala Val Arg Leu Glu Val Lys Gln Ile Ile His Met Leu 
            100                 105                 110         


Arg Glu Tyr Leu Glu Arg Leu Gly Gln His Glu Gln Arg Glu Arg Leu 
        115                 120                 125             


Asp Asp Leu Cys Xaa Arg Leu Gln Met Xaa Ser Xaa Lys Glu Gln Val 
    130                 135                 140                 


Asp Glu Val Xaa Asp Leu Leu Ala Ser Phe Xaa Ser 
145                 150                 155     


<210> 2373
<211> 107
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 2373
Met Pro Met Met Trp Lys Gln Cys Ser Cys Ser Trp Xaa Met Val Leu 
1               5                   10                  15      


Ile Leu Xaa Ser Glu Met Gly Trp Gly Xaa Arg His Cys Xaa Trp Arg 
            20                  25                  30          


Pro Ala Pro Xaa Xaa Phe Leu Ser Ser Pro His Cys Tyr Glu Glu Ile 
        35                  40                  45              


Ile His Met Leu Arg Glu Tyr Leu Glu Arg Leu Gly Gln His Glu Gln 
    50                  55                  60                  


Arg Glu Arg Leu Asp Asp Leu Cys Xaa Arg Leu Gln Met Xaa Ser Xaa 
65                  70                  75                  80  


Lys Glu Gln Val Asp Glu Val Xaa Asp Leu Leu Ala Ser Phe Xaa Ser 
                85                  90                  95      


Leu Ser Leu Gln Met Gln Ser Met Glu Lys Arg 
            100                 105         


<210> 2374
<211> 180
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<400> 2374
Met Pro Met Met Trp Lys Gln Gln Leu Leu Glu Asp Gly Ala Asp Pro 
1               5                   10                  15      


Cys Ala Ala Asp Asp Lys Gly Arg Xaa Ala Leu His Phe Ala Ser Cys 
            20                  25                  30          


Asn Gly Asn Asp Gln Ile Val Gln Leu Leu Leu Asp His Gly Ala Asp 
        35                  40                  45              


Pro Asn Gln Arg Asp Gly Leu Gly Asn Xaa Pro Leu His Leu Ala Ala 
    50                  55                  60                  


Cys Xaa Asn His Val Pro Val Ile Xaa Xaa Leu Leu Arg Gly Gly Ala 
65                  70                  75                  80  


Arg Val Asp Ala Leu Asp Arg Ala Gly Arg Xaa Pro Leu His Leu Ala 
                85                  90                  95      


Lys Ser Lys Leu Asn Ile Leu Gln Glu Gly His Ala Gln Cys Leu Glu 
            100                 105                 110         


Ala Val Arg Leu Glu Val Lys Gln Ile Ile His Met Leu Arg Glu Tyr 
        115                 120                 125             


Leu Glu Arg Leu Gly Gln His Glu Gln Arg Glu Arg Leu Asp Asp Leu 
    130                 135                 140                 


Cys Xaa Arg Leu Gln Met Xaa Ser Xaa Lys Glu Gln Val Asp Glu Val 
145                 150                 155                 160 


Xaa Asp Leu Leu Ala Ser Phe Xaa Ser Leu Ser Leu Gln Met Gln Ser 
                165                 170                 175     


Met Glu Lys Arg 
            180 


<210> 2375
<211> 208
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<400> 2375
Xaa Arg Asp Glu Leu Arg Cys Lys Ile Pro Ala Gly Arg Leu Arg Arg 
1               5                   10                  15      


Ala Ala Arg Pro His Arg Arg Leu Gly Pro Xaa Gly Lys Glu Val His 
            20                  25                  30          


Ala Leu Lys Arg Leu Arg Asp Ser Ala Asn Ala Asn Asp Val Glu Xaa 
        35                  40                  45              


Val Gln Gln Leu Leu Glu Asp Gly Ala Asp Pro Cys Ala Ala Asp Asp 
    50                  55                  60                  


Lys Gly Arg Xaa Ala Leu His Phe Ala Ser Cys Asn Gly Asn Asp Gln 
65                  70                  75                  80  


Ile Val Gln Leu Leu Leu Asp His Gly Ala Asp Pro Asn Gln Arg Asp 
                85                  90                  95      


Gly Leu Gly Asn Xaa Pro Leu His Leu Glu Cys Ser Pro Gln Leu Val 
            100                 105                 110         


Pro Ala Gly Ala Arg Val Asp Ala Leu Asp Arg Ala Gly Arg Xaa Pro 
        115                 120                 125             


Leu His Leu Ala Lys Ser Lys Leu Asn Ile Leu Gln Glu Gly His Ala 
    130                 135                 140                 


Gln Cys Leu Glu Ala Val Arg Leu Glu Val Lys Gln Ile Ile His Met 
145                 150                 155                 160 


Leu Arg Glu Tyr Leu Glu Arg Leu Gly Gln His Glu Gln Arg Glu Arg 
                165                 170                 175     


Leu Asp Asp Leu Cys Xaa Arg Leu Gln Met Xaa Ser Xaa Lys Glu Gln 
            180                 185                 190         


Val Asp Glu Val Xaa Asp Leu Leu Ala Ser Phe Xaa Ser Leu Ser Leu 
        195                 200                 205             


<210> 2376
<211> 178
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<400> 2376
Xaa Arg Leu Arg Arg Pro Gly Pro Arg Gly Ala Val Ala Met Ala Ala 
1               5                   10                  15      


Ala Ala Gly Asp Ala Asp Asp Glu Pro Arg Ser Gly His Ser Ser Ser 
            20                  25                  30          


Glu Gly Glu Cys Ala Val Ala Pro Glu Pro Leu Xaa Asp Ala Glu Gly 
        35                  40                  45              


Leu Phe Ser Phe Ala Asp Phe Gly Ser Ala Leu Gly Gly Gly Gly Ala 
    50                  55                  60                  


Gly Leu Ser Gly Arg Ala Ser Gly Gly Ala Gln Ser Pro Leu Arg Tyr 
65                  70                  75                  80  


Leu His Val Leu Trp Gln Gln Asp Ala Glu Pro Arg Asp Glu Leu Arg 
                85                  90                  95      


Cys Lys Ile Pro Ala Gly Arg Leu Arg Arg Ala Ala Arg Pro His Arg 
            100                 105                 110         


Arg Leu Gly Pro Xaa Gly Lys Glu Val His Ala Leu Lys Arg Leu Arg 
        115                 120                 125             


Asp Ser Ala Asn Ala Asn Asp Val Glu Xaa Val Gln Gln Leu Leu Glu 
    130                 135                 140                 


Asp Gly Ala Asp Pro Cys Ala Ala Asp Asp Lys Gly Arg Xaa Ala Leu 
145                 150                 155                 160 


His Phe Ala Ser Cys Asn Gly Asn Asp Gln Ile Ala Ala Pro Gly Pro 
                165                 170                 175     


Trp Cys 
        


<210> 2377
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 2377
Lys Leu Gly Gln Met Glu Asn Lys Xaa Gln His Gln Met Arg Val Leu 
1               5                   10                  15      


Asp Lys Leu Met Val Glu Arg Leu Ser Ala Glu Arg Xaa Glu Cys Leu 
            20                  25                  30          


Asn Arg Leu Gln Gln His Ser Asp Xaa Glu Lys His Glu Gly Glu Lys 
        35                  40                  45              


Arg Gln Ile Ser Leu Val Asp Glu Leu Lys Xaa Trp Cys Met Leu Lys 
    50                  55                  60                  


Ile Gln Asn Leu Glu Gln Lys Leu Ser Gly Asp Ser Arg Ala Cys Arg 
65                  70                  75                  80  


Ala Lys Ser Xaa Pro Ser Xaa Cys Glu Ser Ser Xaa Gly Asn Pro His 
                85                  90                  95      


Xaa Glu Ser Pro Phe Val Gln Lys Glu His Asp Gln Gln Leu Leu Tyr 
            100                 105                 110         


Ser Pro Ala Leu Lys Gly Ser Xaa Tyr Ala Arg Ala Val Gly Asn Xaa 
        115                 120                 125             


Gly Trp 
    130 


<210> 2378
<211> 54
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 2378
Met Ser Gln Gln Asp Ala Val Ala Ala Leu Ser Glu Arg Leu Leu Val 
1               5                   10                  15      


Ala Ala Tyr Lys Gly Gln Xaa Glu Asn Val Val Gln Leu Ile Asn Lys 
            20                  25                  30          


Gly Ala Arg Val Ala Val Xaa Lys Gly Asp Gln Xaa Ala Leu His Arg 
        35                  40                  45              


Ala Xaa Val Val Gly Asn 
    50                  


<210> 2379
<211> 230
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<400> 2379
Met Ser Gln Gln Asp Ala Val Ala Ala Leu Ser Glu Arg Leu Leu Val 
1               5                   10                  15      


Ala Ala Tyr Lys Gly Gln Xaa Glu Asn Val Val Gln Leu Ile Asn Lys 
            20                  25                  30          


Gly Ala Arg Val Ala Val Xaa Lys Gly Ser Val Ser Ala Gly Asp Xaa 
        35                  40                  45              


Pro Ser Ser Glu Gln Ala Val Ala Arg Lys Glu Glu Ala Arg Glu Glu 
    50                  55                  60                  


Phe Leu Ser Ala Ser Pro Glu Pro Arg Ala Lys Asp Asp Arg Arg Arg 
65                  70                  75                  80  


Lys Ser Arg Pro Lys Val Ser Ala Phe Ser Asp Pro Xaa Pro Pro Ala 
                85                  90                  95      


Asp Gln Gln Pro Gly His Gln Lys Asn Leu His Ala His Asn His Pro 
            100                 105                 110         


Lys Lys Arg Asn Arg His Arg Cys Ser Ser Pro Pro Pro Pro His Glu 
        115                 120                 125             


Phe Arg Ala Tyr Gln Leu Tyr Xaa Leu Tyr Arg Gly Lys Asp Gly Lys 
    130                 135                 140                 


Val Met Gln Ala Pro Ile Asn Gly Cys Arg Cys Glu Pro Leu Ile Asn 
145                 150                 155                 160 


Lys Leu Glu Asn Gln Leu Glu Ala Xaa Val Glu Glu Ile Lys Ala Glu 
                165                 170                 175     


Leu Gly Ser Val Gln Asp Lys Met Asn Xaa Lys Leu Gly Gln Met Glu 
            180                 185                 190         


Asn Lys Xaa Gln His Gln Met Arg Val Leu Asp Lys Leu Met Val Glu 
        195                 200                 205             


Arg Leu Ser Ala Glu Arg Xaa Glu Cys Leu Asn Arg Leu Gln Gln His 
    210                 215                 220                 


Ser Asp Xaa Glu Lys His 
225                 230 


<210> 2380
<211> 80
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<400> 2380
Met Ser Gln Gln Asp Ala Val Ala Ala Leu Ser Glu Arg Leu Leu Val 
1               5                   10                  15      


Ala Ala Tyr Lys Gly Gln Xaa Glu Asn Val Val Gln Leu Ile Asn Lys 
            20                  25                  30          


Gly Ala Arg Val Ala Val Xaa Lys His Gly Arg Xaa Pro Leu His Leu 
        35                  40                  45              


Ala Ala Asn Lys Gly His Leu Pro Val Val Gln Ile Leu Leu Lys Ala 
    50                  55                  60                  


Gly Cys Asp Leu Asp Val Gln Asp Asp Gly Asp Gln Xaa Ala Leu His 
65                  70                  75                  80  


<210> 2381
<211> 102
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 2381
Met Ser Gln Gln Asp Ala Val Ala Ala Leu Ser Glu Arg Leu Leu Val 
1               5                   10                  15      


Ala Ala Tyr Lys Gly Gln Xaa Glu Asn Val Val Gln Leu Ile Asn Lys 
            20                  25                  30          


Gly Ala Arg Val Ala Val Xaa Lys His Gly Arg Xaa Pro Leu His Leu 
        35                  40                  45              


Ala Ala Asn Lys Gly His Leu Pro Val Val Gln Ile Leu Leu Lys Ala 
    50                  55                  60                  


Gly Cys Asp Leu Asp Val Gln Asp Asp Gly Asp Gln Xaa Ala Leu His 
65                  70                  75                  80  


Arg Ala Xaa Val Val Gly Asn Xaa Glu Ile Ile Ala Ala Leu Ile His 
                85                  90                  95      


Glu Gly Cys Ala Leu Asp 
            100         


<210> 2382
<211> 663
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<400> 2382
Met Ser Gln Gln Asp Ala Val Ala Ala Leu Ser Glu Arg Leu Leu Val 
1               5                   10                  15      


Ala Ala Tyr Lys Gly Gln Xaa Glu Asn Val Val Gln Leu Ile Asn Lys 
            20                  25                  30          


Gly Ala Arg Val Ala Val Xaa Lys His Gly Arg Xaa Pro Leu His Leu 
        35                  40                  45              


Ala Ala Asn Lys Gly His Leu Pro Val Val Gln Ile Leu Leu Lys Ala 
    50                  55                  60                  


Gly Cys Asp Leu Asp Val Gln Asp Asp Gly Asp Gln Xaa Ala Leu His 
65                  70                  75                  80  


Arg Ala Xaa Val Val Gly Asn Xaa Glu Ile Ile Ala Ala Leu Ile His 
                85                  90                  95      


Glu Gly Cys Ala Leu Asp Arg Gln Asp Lys Ala Gly Asn Xaa Ala Leu 
            100                 105                 110         


His Leu Ala Cys Gln Asn Ser His Ser Gln Ser Xaa Arg Val Leu Leu 
        115                 120                 125             


Leu Ala Gly Ser Arg Ala Asp Leu Lys Asn Asn Ala Gly Asp Xaa Cys 
    130                 135                 140                 


Leu His Val Ala Ala Arg Tyr Asn His Leu Ser Ile Ile Arg Leu Leu 
145                 150                 155                 160 


Leu Xaa Ala Phe Cys Ser Val His Glu Lys Asn Gln Ala Gly Asp Xaa 
                165                 170                 175     


Ala Leu His Val Ala Ala Ala Leu Asn His Lys Lys Val Ala Lys Ile 
            180                 185                 190         


Leu Leu Glu Ala Gly Ala Asp Xaa Xaa Ile Val Asn Asn Val Leu Arg 
        195                 200                 205             


Phe Ser Arg Gly Arg Ser Leu Arg Lys Lys Arg Glu Arg Leu Lys Glu 
    210                 215                 220                 


Glu Arg Arg Ala Gln Ser Val Pro Arg Asp Glu Val Ala Gln Ser Lys 
225                 230                 235                 240 


Gly Ser Val Ser Ala Gly Asp Xaa Pro Ser Ser Glu Gln Ala Val Ala 
                245                 250                 255     


Arg Lys Glu Glu Ala Arg Glu Glu Phe Leu Ser Ala Ser Pro Glu Pro 
            260                 265                 270         


Arg Ala Lys Asp Asp Arg Arg Arg Lys Ser Arg Pro Lys Val Ser Ala 
        275                 280                 285             


Phe Ser Asp Pro Xaa Pro Pro Ala Asp Gln Gln Pro Gly His Gln Lys 
    290                 295                 300                 


Asn Leu His Ala His Asn His Pro Lys Lys Arg Asn Arg His Arg Cys 
305                 310                 315                 320 


Ser Ser Pro Pro Pro Pro His Glu Phe Arg Ala Tyr Gln Leu Tyr Xaa 
                325                 330                 335     


Leu Tyr Arg Gly Lys Asp Gly Lys Val Met Gln Ala Pro Ile Asn Gly 
            340                 345                 350         


Cys Arg Cys Glu Pro Leu Ile Asn Lys Leu Glu Asn Gln Leu Glu Ala 
        355                 360                 365             


Xaa Val Glu Glu Ile Lys Ala Glu Leu Gly Ser Val Gln Asp Lys Met 
    370                 375                 380                 


Asn Xaa Lys Leu Gly Gln Met Glu Asn Lys Xaa Gln His Gln Met Arg 
385                 390                 395                 400 


Val Leu Asp Lys Leu Met Val Glu Arg Leu Ser Ala Glu Arg Xaa Glu 
                405                 410                 415     


Cys Leu Asn Arg Leu Gln Gln His Ser Asp Xaa Glu Lys His Glu Gly 
            420                 425                 430         


Glu Lys Arg Gln Ile Ser Leu Val Asp Glu Leu Lys Xaa Trp Cys Met 
        435                 440                 445             


Leu Lys Ile Gln Asn Leu Glu Gln Lys Leu Ser Gly Asp Ser Arg Ala 
    450                 455                 460                 


Cys Arg Ala Lys Ser Xaa Pro Ser Xaa Cys Val Asp Gln Leu Val Val 
465                 470                 475                 480 


Xaa Ala Gly Pro Ala Ala Ala Ser Asp Ser Ser Pro Pro Val Val Arg 
                485                 490                 495     


Pro Lys Glu Lys Ala Leu Asn Ser Xaa Ala Xaa Gln Arg Leu Gln Gln 
            500                 505                 510         


Glu Leu Ser Ser Ser Asp Cys Xaa Gly Ser Arg Leu Arg Asn Val Lys 
        515                 520                 525             


Val Gln Xaa Ala Leu Leu Pro Met Asn Glu Ala Ala Arg Ser Asp Gln 
    530                 535                 540                 


Gln Ala Gly Pro Cys Val Asn Arg Gly Xaa Gln Xaa Lys Lys Ser Gly 
545                 550                 555                 560 


Lys Ser Gly Pro Xaa Arg His Arg Ala Gln Gln Pro Ala Ala Ser Ser 
                565                 570                 575     


Xaa Cys Gly Gln Pro Pro Pro Ala Xaa Gly Ser Glu Gln Xaa Gly Pro 
            580                 585                 590         


His Ile Arg Asp Xaa Ser Gln Ala Leu Glu Leu Xaa Gln Tyr Phe Phe 
        595                 600                 605             


Glu Ala Val Ser Xaa Gln Met Glu Lys Trp Tyr Glu Arg Lys Ile Glu 
    610                 615                 620                 


Glu Ala Arg Ser Gln Ala Asn Gln Lys Ala Gln Gln Asp Lys Ala Xaa 
625                 630                 635                 640 


Leu Lys Glu His Ile Lys Ser Leu Glu Glu Glu Leu Ala Lys Leu Arg 
                645                 650                 655     


Xaa Arg Val Gln Lys Glu Asn 
            660             


<210> 2383
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 2383
Met Ser Gln Gln Asp Ala Val Ala Ala Leu Ser Glu Arg Leu Leu Val 
1               5                   10                  15      


Ala Ala Tyr Lys Gly Gln Xaa Glu Asn Val Val Gln Leu Ile Asn Lys 
            20                  25                  30          


Gly Ala Arg Val Ala Val Xaa Lys His Gly Arg Xaa Pro Leu His Leu 
        35                  40                  45              


Ala Ala Asn Lys Gly His Leu Pro Val Val Gln Ile Leu Leu Lys Ala 
    50                  55                  60                  


Gly Cys Asp Leu Asp Val Gln Asp Asp Gly Asp Gln Xaa Ala Leu His 
65                  70                  75                  80  


Arg Ala Xaa Val Val Gly Asn Xaa Glu Ile Ile Ala Ala Leu Ile His 
                85                  90                  95      


Glu Gly Cys Ala Leu Asp Arg Gln Asp Lys Asp Gly Asn Xaa Ala Leu 
            100                 105                 110         


His Glu Ala Ser Trp His 
        115             


<210> 2384
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<400> 2384
Met Ser Gln Gln Asp Ala Val Ala Ala Leu Ser Glu Arg Leu Leu Val 
1               5                   10                  15      


Ala Ala Tyr Lys Gly Gln Xaa Glu Asn Val Val Gln Leu Ile Asn Lys 
            20                  25                  30          


Gly Ala Arg Val Ala Val Xaa Lys His Gly Arg Xaa Pro Leu His Leu 
        35                  40                  45              


Ala Ala Asn Lys Gly His Leu Pro Val Val Gln Ile Leu Leu Lys Ala 
    50                  55                  60                  


Gly Cys Asp Leu Asp Val Gln Asp Asp Gly Asp Gln Xaa Ala Leu His 
65                  70                  75                  80  


Arg Ala Xaa Val Val Gly Asn Xaa Glu Ile Ile Ala Ala Leu Ile His 
                85                  90                  95      


Glu Gly Cys Ala Leu Asp Arg Gln Asp Lys Asp Gly Asn Xaa Ala Leu 
            100                 105                 110         


His Glu Ala Ser Trp His Gly Phe Ser Gln Ser Ala Lys Leu Leu Ile 
        115                 120                 125             


Lys Ala Gly Ala Asn Val Leu Ala Lys Asn Lys Ala Gly Asn Xaa Ala 
    130                 135                 140                 


Leu His Leu Ala Cys Gln Asn Ser His Ser Gln Ser Xaa Arg Val Leu 
145                 150                 155                 160 


Leu Leu Ala Gly Ser Arg Ala Asp Leu Lys Asn Asn Ala Gly Asp 
                165                 170                 175 


<210> 2385
<211> 307
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<400> 2385
Met Ser Gln Gln Asp Ala Val Ala Ala Leu Ser Glu Arg Leu Leu Val 
1               5                   10                  15      


Ala Ala Tyr Lys Gly Gln Xaa Glu Asn Val Val Gln Leu Ile Asn Lys 
            20                  25                  30          


Gly Ala Arg Val Ala Val Xaa Lys His Gly Arg Xaa Pro Leu His Leu 
        35                  40                  45              


Ala Ala Asn Lys Gly His Leu Pro Val Val Gln Ile Leu Leu Lys Ala 
    50                  55                  60                  


Gly Cys Asp Leu Asp Val Gln Asp Asp Gly Asp Gln Xaa Ala Leu His 
65                  70                  75                  80  


Arg Ala Xaa Val Val Gly Asn Xaa Glu Ile Ile Ala Ala Leu Ile His 
                85                  90                  95      


Glu Gly Cys Ala Leu Asp Arg Gln Asp Lys Asp Gly Asn Xaa Ala Leu 
            100                 105                 110         


His Glu Ala Ser Trp His Gly Phe Ser Gln Ser Ala Lys Leu Leu Ile 
        115                 120                 125             


Lys Ala Gly Ala Asn Val Leu Ala Lys Asn Lys Ala Gly Asn Xaa Ala 
    130                 135                 140                 


Leu His Leu Ala Cys Gln Asn Ser His Ser Gln Ser Xaa Arg Val Leu 
145                 150                 155                 160 


Leu Leu Ala Gly Ser Arg Ala Asp Leu Lys Asn Asn Ala Gly Asp Xaa 
                165                 170                 175     


Cys Leu His Val Ala Ala Arg Tyr Asn His Leu Ser Ile Ile Arg Leu 
            180                 185                 190         


Leu Leu Xaa Ala Phe Cys Ser Val His Glu Lys Asn Gln Ala Gly Asp 
        195                 200                 205             


Xaa Ala Leu His Val Ala Ala Ala Leu Asn His Lys Lys Val Ala Lys 
    210                 215                 220                 


Ile Leu Leu Glu Ala Gly Ala Asp Xaa Xaa Ile Val Asn Asn Ala Gly 
225                 230                 235                 240 


Gln Xaa Pro Leu Glu Xaa Ala Arg Tyr His Asn Asn Pro Glu Val Ala 
                245                 250                 255     


Leu Leu Leu Xaa Lys Ala Pro Gln Val Gly Phe Xaa Ala Leu Ser Met 
            260                 265                 270         


Val Leu Ile Met Arg Asp Tyr Lys Val Val Gly Xaa Pro Gly Cys Asn 
        275                 280                 285             


Leu Leu Lys Pro Leu Gln Xaa Asn Leu Asn Met Glu Cys Asn Gln Ala 
    290                 295                 300                 


Val Glu Val 
305         


<210> 2386
<211> 692
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<400> 2386
Met Ser Gln Gln Asp Ala Val Ala Ala Leu Ser Glu Arg Leu Leu Val 
1               5                   10                  15      


Ala Ala Tyr Lys Gly Gln Xaa Glu Asn Val Val Gln Leu Ile Asn Lys 
            20                  25                  30          


Gly Ala Arg Val Ala Val Xaa Lys His Gly Arg Xaa Pro Leu His Leu 
        35                  40                  45              


Ala Ala Asn Lys Gly His Leu Pro Val Val Gln Ile Leu Leu Lys Ala 
    50                  55                  60                  


Gly Cys Asp Leu Asp Val Gln Asp Asp Gly Asp Gln Xaa Ala Leu His 
65                  70                  75                  80  


Arg Ala Xaa Val Val Gly Asn Xaa Glu Ile Ile Ala Ala Leu Ile His 
                85                  90                  95      


Glu Gly Cys Ala Leu Asp Arg Gln Asp Lys Asp Gly Asn Xaa Ala Leu 
            100                 105                 110         


His Glu Ala Ser Trp His Gly Phe Ser Gln Ser Ala Lys Leu Leu Ile 
        115                 120                 125             


Lys Ala Gly Ala Asn Val Leu Ala Lys Asn Lys Ala Gly Asn Xaa Ala 
    130                 135                 140                 


Leu His Leu Ala Cys Gln Asn Ser His Ser Gln Ser Xaa Arg Val Leu 
145                 150                 155                 160 


Leu Leu Ala Gly Ser Arg Ala Asp Leu Lys Asn Asn Ala Gly Asp Xaa 
                165                 170                 175     


Cys Leu His Val Ala Ala Arg Tyr Asn His Leu Ser Ile Ile Arg Leu 
            180                 185                 190         


Leu Leu Xaa Ala Phe Cys Ser Val His Glu Lys Asn Gln Ala Gly Asp 
        195                 200                 205             


Xaa Ala Leu His Val Ala Ala Ala Leu Asn His Lys Lys Val Ala Lys 
    210                 215                 220                 


Ile Leu Leu Glu Ala Gly Ala Asp Xaa Xaa Ile Val Asn Asn Ala Gly 
225                 230                 235                 240 


Gln Xaa Pro Leu Glu Xaa Ala Arg Tyr His Asn Asn Pro Glu Val Ala 
                245                 250                 255     


Leu Leu Leu Xaa Lys Ala Pro Gln Gly Ser Val Ser Ala Gly Asp Xaa 
            260                 265                 270         


Pro Ser Ser Glu Gln Ala Val Ala Arg Lys Glu Glu Ala Arg Glu Glu 
        275                 280                 285             


Phe Leu Ser Ala Ser Pro Glu Pro Arg Ala Lys Asp Asp Arg Arg Arg 
    290                 295                 300                 


Lys Ser Arg Pro Lys Val Ser Ala Phe Ser Asp Pro Xaa Pro Pro Ala 
305                 310                 315                 320 


Asp Gln Gln Pro Gly His Gln Lys Asn Leu His Ala His Asn His Pro 
                325                 330                 335     


Lys Lys Arg Asn Arg His Arg Cys Ser Ser Pro Pro Pro Pro His Glu 
            340                 345                 350         


Phe Arg Ala Tyr Gln Leu Tyr Xaa Leu Tyr Arg Gly Lys Asp Gly Lys 
        355                 360                 365             


Val Met Gln Ala Pro Ile Asn Gly Cys Arg Cys Glu Pro Leu Ile Asn 
    370                 375                 380                 


Lys Leu Glu Asn Gln Leu Glu Ala Xaa Val Glu Glu Ile Lys Ala Glu 
385                 390                 395                 400 


Leu Gly Ser Val Gln Asp Lys Met Asn Xaa Lys Leu Gly Gln Met Glu 
                405                 410                 415     


Asn Lys Xaa Gln His Gln Met Arg Val Leu Asp Lys Leu Met Val Glu 
            420                 425                 430         


Arg Leu Ser Ala Glu Arg Xaa Glu Cys Leu Asn Arg Leu Gln Gln His 
        435                 440                 445             


Ser Asp Xaa Glu Lys His Glu Gly Glu Lys Arg Gln Ile Ser Leu Val 
    450                 455                 460                 


Asp Glu Leu Lys Xaa Trp Cys Met Leu Lys Ile Gln Asn Leu Glu Gln 
465                 470                 475                 480 


Lys Leu Ser Gly Asp Ser Arg Ala Cys Arg Ala Lys Ser Xaa Pro Ser 
                485                 490                 495     


Xaa Cys Glu Ser Ser Xaa Gly Val Asp Gln Leu Val Val Xaa Ala Gly 
            500                 505                 510         


Pro Ala Ala Ala Ser Asp Ser Ser Pro Pro Val Val Arg Pro Lys Glu 
        515                 520                 525             


Lys Ala Leu Asn Ser Xaa Ala Xaa Gln Arg Leu Gln Gln Glu Leu Ser 
    530                 535                 540                 


Ser Ser Asp Cys Xaa Gly Ser Arg Leu Arg Asn Val Lys Val Gln Xaa 
545                 550                 555                 560 


Ala Leu Leu Pro Met Asn Glu Ala Ala Arg Ser Asp Gln Gln Ala Gly 
                565                 570                 575     


Pro Cys Val Asn Arg Gly Xaa Gln Xaa Lys Lys Ser Gly Lys Ser Gly 
            580                 585                 590         


Pro Xaa Arg His Arg Ala Gln Gln Pro Ala Ala Ser Ser Xaa Cys Gly 
        595                 600                 605             


Gln Pro Pro Pro Ala Xaa Gly Ser Glu Gln Xaa Gly Pro His Ile Arg 
    610                 615                 620                 


Asp Xaa Ser Gln Ala Leu Glu Leu Xaa Gln Tyr Phe Phe Glu Ala Val 
625                 630                 635                 640 


Ser Xaa Gln Met Glu Lys Trp Tyr Glu Arg Lys Ile Glu Glu Ala Arg 
                645                 650                 655     


Ser Gln Ala Asn Gln Lys Ala Gln Gln Asp Lys Ala Xaa Leu Lys Glu 
            660                 665                 670         


His Ile Lys Ser Leu Glu Glu Glu Leu Ala Lys Leu Arg Xaa Arg Val 
        675                 680                 685             


Gln Lys Glu Asn 
    690         


<210> 2387
<211> 722
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<400> 2387
Met Ser Gln Gln Asp Ala Val Ala Ala Leu Ser Glu Arg Leu Leu Val 
1               5                   10                  15      


Ala Ala Tyr Lys Gly Gln Xaa Glu Asn Val Val Gln Leu Ile Asn Lys 
            20                  25                  30          


Gly Ala Arg Val Ala Val Xaa Lys His Gly Arg Xaa Pro Leu His Leu 
        35                  40                  45              


Ala Ala Asn Lys Gly His Leu Pro Val Val Gln Ile Leu Leu Lys Ala 
    50                  55                  60                  


Gly Cys Asp Leu Asp Val Gln Asp Asp Gly Asp Gln Xaa Ala Leu His 
65                  70                  75                  80  


Arg Ala Xaa Val Val Gly Asn Xaa Glu Ile Ile Ala Ala Leu Ile His 
                85                  90                  95      


Glu Gly Cys Ala Leu Asp Arg Gln Asp Lys Asp Gly Asn Xaa Ala Leu 
            100                 105                 110         


His Glu Ala Ser Trp His Gly Phe Ser Gln Ser Ala Lys Leu Leu Ile 
        115                 120                 125             


Lys Ala Gly Ala Asn Val Leu Ala Lys Asn Lys Ala Gly Asn Xaa Ala 
    130                 135                 140                 


Leu His Leu Ala Cys Gln Asn Ser His Ser Gln Ser Xaa Arg Val Leu 
145                 150                 155                 160 


Leu Leu Ala Gly Ser Arg Ala Asp Leu Lys Asn Asn Ala Gly Asp Xaa 
                165                 170                 175     


Cys Leu His Val Ala Ala Arg Tyr Asn His Leu Ser Ile Ile Arg Leu 
            180                 185                 190         


Leu Leu Xaa Ala Phe Cys Ser Val His Glu Lys Asn Gln Ala Gly Asp 
        195                 200                 205             


Xaa Ala Leu His Val Ala Ala Ala Leu Asn His Lys Lys Val Ala Lys 
    210                 215                 220                 


Ile Leu Leu Glu Ala Gly Ala Asp Xaa Xaa Ile Val Asn Asn Ala Gly 
225                 230                 235                 240 


Gln Xaa Pro Leu Glu Xaa Ala Arg Tyr His Asn Asn Pro Glu Val Ala 
                245                 250                 255     


Leu Leu Leu Xaa Lys Ala Pro Gln Val Leu Arg Phe Ser Arg Gly Arg 
            260                 265                 270         


Ser Leu Arg Lys Lys Arg Glu Arg Leu Lys Glu Glu Arg Arg Ala Gln 
        275                 280                 285             


Ser Val Pro Arg Asp Glu Val Ala Gln Ser Lys Gly Ser Val Ser Ala 
    290                 295                 300                 


Gly Asp Xaa Pro Ser Ser Glu Gln Ala Val Ala Arg Lys Glu Glu Ala 
305                 310                 315                 320 


Arg Glu Glu Phe Leu Ser Ala Ser Pro Glu Pro Arg Ala Lys Asp Asp 
                325                 330                 335     


Arg Arg Arg Lys Ser Arg Pro Lys Val Ser Ala Phe Ser Asp Pro Xaa 
            340                 345                 350         


Pro Pro Ala Asp Gln Gln Pro Gly His Gln Lys Asn Leu His Ala His 
        355                 360                 365             


Asn His Pro Lys Lys Arg Asn Arg His Arg Cys Ser Ser Pro Pro Pro 
    370                 375                 380                 


Pro His Glu Phe Arg Ala Tyr Gln Leu Tyr Xaa Leu Tyr Arg Gly Lys 
385                 390                 395                 400 


Asp Gly Lys Val Met Gln Ala Pro Ile Asn Gly Cys Arg Cys Glu Pro 
                405                 410                 415     


Leu Ile Asn Lys Leu Glu Asn Gln Leu Glu Ala Xaa Val Glu Glu Ile 
            420                 425                 430         


Lys Ala Glu Leu Gly Ser Val Gln Asp Lys Met Asn Xaa Lys Leu Gly 
        435                 440                 445             


Gln Met Glu Asn Lys Xaa Gln His Gln Met Arg Val Leu Asp Lys Leu 
    450                 455                 460                 


Met Val Glu Arg Leu Ser Ala Glu Arg Xaa Glu Cys Leu Asn Arg Leu 
465                 470                 475                 480 


Gln Gln His Ser Asp Xaa Glu Lys His Glu Gly Glu Lys Arg Gln Ile 
                485                 490                 495     


Ser Leu Val Asp Glu Leu Lys Xaa Trp Cys Met Leu Lys Ile Gln Asn 
            500                 505                 510         


Leu Glu Gln Lys Leu Ser Gly Asp Ser Arg Ala Cys Arg Ala Lys Ser 
        515                 520                 525             


Xaa Pro Ser Xaa Cys Val Asp Gln Leu Val Val Xaa Ala Gly Pro Ala 
    530                 535                 540                 


Ala Ala Ser Asp Ser Ser Pro Pro Val Val Arg Pro Lys Glu Lys Ala 
545                 550                 555                 560 


Leu Asn Ser Xaa Ala Xaa Gln Arg Leu Gln Gln Glu Leu Ser Ser Ser 
                565                 570                 575     


Asp Cys Xaa Gly Ser Arg Leu Arg Asn Val Lys Val Gln Xaa Ala Leu 
            580                 585                 590         


Leu Pro Met Asn Glu Ala Ala Arg Ser Asp Gln Gln Ala Gly Pro Cys 
        595                 600                 605             


Val Asn Arg Gly Xaa Gln Xaa Lys Lys Ser Gly Lys Ser Gly Pro Xaa 
    610                 615                 620                 


Arg His Arg Ala Gln Gln Pro Ala Ala Ser Ser Xaa Cys Gly Gln Pro 
625                 630                 635                 640 


Pro Pro Ala Xaa Gly Ser Glu Gln Xaa Gly Pro His Ile Arg Asp Xaa 
                645                 650                 655     


Ser Gln Ala Leu Glu Leu Xaa Gln Tyr Phe Phe Glu Ala Val Ser Xaa 
            660                 665                 670         


Gln Met Glu Lys Trp Tyr Glu Arg Lys Ile Glu Glu Ala Arg Ser Gln 
        675                 680                 685             


Ala Asn Gln Lys Ala Gln Gln Asp Lys Ala Xaa Leu Lys Glu His Ile 
    690                 695                 700                 


Lys Ser Leu Glu Glu Glu Leu Ala Lys Leu Arg Xaa Arg Val Gln Lys 
705                 710                 715                 720 


Glu Asn 
        


<210> 2388
<211> 727
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<400> 2388
Met Ser Gln Gln Asp Ala Val Ala Ala Leu Ser Glu Arg Leu Leu Val 
1               5                   10                  15      


Ala Ala Tyr Lys Gly Gln Xaa Glu Asn Val Val Gln Leu Ile Asn Lys 
            20                  25                  30          


Gly Ala Arg Val Ala Val Xaa Lys His Gly Arg Xaa Pro Leu His Leu 
        35                  40                  45              


Ala Ala Asn Lys Gly His Leu Pro Val Val Gln Ile Leu Leu Lys Ala 
    50                  55                  60                  


Gly Cys Asp Leu Asp Val Gln Asp Asp Gly Asp Gln Xaa Ala Leu His 
65                  70                  75                  80  


Arg Ala Xaa Val Val Gly Asn Xaa Glu Ile Ile Ala Ala Leu Ile His 
                85                  90                  95      


Glu Gly Cys Ala Leu Asp Arg Gln Asp Lys Asp Gly Asn Xaa Ala Leu 
            100                 105                 110         


His Glu Ala Ser Trp His Gly Phe Ser Gln Ser Ala Lys Leu Leu Ile 
        115                 120                 125             


Lys Ala Gly Ala Asn Val Leu Ala Lys Asn Lys Ala Gly Asn Xaa Ala 
    130                 135                 140                 


Leu His Leu Ala Cys Gln Asn Ser His Ser Gln Ser Xaa Arg Val Leu 
145                 150                 155                 160 


Leu Leu Ala Gly Ser Arg Ala Asp Leu Lys Asn Asn Ala Gly Asp Xaa 
                165                 170                 175     


Cys Leu His Val Ala Ala Arg Tyr Asn His Leu Ser Ile Ile Arg Leu 
            180                 185                 190         


Leu Leu Xaa Ala Phe Cys Ser Val His Glu Lys Asn Gln Ala Gly Asp 
        195                 200                 205             


Xaa Ala Leu His Val Ala Ala Ala Leu Asn His Lys Lys Val Ala Lys 
    210                 215                 220                 


Ile Leu Leu Glu Ala Gly Ala Asp Xaa Xaa Ile Val Asn Asn Ala Gly 
225                 230                 235                 240 


Gln Xaa Pro Leu Glu Xaa Ala Arg Tyr His Asn Asn Pro Glu Val Ala 
                245                 250                 255     


Leu Leu Leu Xaa Lys Ala Pro Gln Val Leu Arg Phe Ser Arg Gly Arg 
            260                 265                 270         


Ser Leu Arg Lys Lys Arg Glu Arg Leu Lys Glu Glu Arg Arg Ala Gln 
        275                 280                 285             


Ser Val Pro Arg Asp Glu Val Ala Gln Ser Lys Gly Ser Val Ser Ala 
    290                 295                 300                 


Gly Asp Xaa Pro Ser Ser Glu Gln Ala Val Ala Arg Lys Glu Glu Ala 
305                 310                 315                 320 


Arg Glu Glu Phe Leu Ser Ala Ser Pro Glu Pro Arg Ala Lys Asp Asp 
                325                 330                 335     


Arg Arg Arg Lys Ser Arg Pro Lys Val Ser Ala Phe Ser Asp Pro Xaa 
            340                 345                 350         


Pro Pro Ala Asp Gln Gln Pro Gly His Gln Lys Asn Leu His Ala His 
        355                 360                 365             


Asn His Pro Lys Lys Arg Asn Arg His Arg Cys Ser Ser Pro Pro Pro 
    370                 375                 380                 


Pro His Glu Phe Arg Ala Tyr Gln Leu Tyr Xaa Leu Tyr Arg Gly Lys 
385                 390                 395                 400 


Asp Gly Lys Val Met Gln Ala Pro Ile Asn Gly Cys Arg Cys Glu Pro 
                405                 410                 415     


Leu Ile Asn Lys Leu Glu Asn Gln Leu Glu Ala Xaa Val Glu Glu Ile 
            420                 425                 430         


Lys Ala Glu Leu Gly Ser Val Gln Asp Lys Met Asn Xaa Lys Leu Gly 
        435                 440                 445             


Gln Met Glu Asn Lys Xaa Gln His Gln Met Arg Val Leu Asp Lys Leu 
    450                 455                 460                 


Met Val Glu Arg Leu Ser Ala Glu Arg Xaa Glu Cys Leu Asn Arg Leu 
465                 470                 475                 480 


Gln Gln His Ser Asp Xaa Glu Lys His Glu Gly Glu Lys Arg Gln Ile 
                485                 490                 495     


Ser Leu Val Asp Glu Leu Lys Xaa Trp Cys Met Leu Lys Ile Gln Asn 
            500                 505                 510         


Leu Glu Gln Lys Leu Ser Gly Asp Ser Arg Ala Cys Arg Ala Lys Ser 
        515                 520                 525             


Xaa Pro Ser Xaa Cys Glu Ser Ser Xaa Gly Val Asp Gln Leu Val Val 
    530                 535                 540                 


Xaa Ala Gly Pro Ala Ala Ala Ser Asp Ser Ser Pro Pro Val Val Arg 
545                 550                 555                 560 


Pro Lys Glu Lys Ala Leu Asn Ser Xaa Ala Xaa Gln Arg Leu Gln Gln 
                565                 570                 575     


Glu Leu Ser Ser Ser Asp Cys Xaa Gly Ser Arg Leu Arg Asn Val Lys 
            580                 585                 590         


Val Gln Xaa Ala Leu Leu Pro Met Asn Glu Ala Ala Arg Ser Asp Gln 
        595                 600                 605             


Gln Ala Gly Pro Cys Val Asn Arg Gly Xaa Gln Xaa Lys Lys Ser Gly 
    610                 615                 620                 


Lys Ser Gly Pro Xaa Arg His Arg Ala Gln Gln Pro Ala Ala Ser Ser 
625                 630                 635                 640 


Xaa Cys Gly Gln Pro Pro Pro Ala Xaa Gly Ser Glu Gln Xaa Gly Pro 
                645                 650                 655     


His Ile Arg Asp Xaa Ser Gln Ala Leu Glu Leu Xaa Gln Tyr Phe Phe 
            660                 665                 670         


Glu Ala Val Ser Xaa Gln Met Glu Lys Trp Tyr Glu Arg Lys Ile Glu 
        675                 680                 685             


Glu Ala Arg Ser Gln Ala Asn Gln Lys Ala Gln Gln Asp Lys Ala Xaa 
    690                 695                 700                 


Leu Lys Glu His Ile Lys Ser Leu Glu Glu Glu Leu Ala Lys Leu Arg 
705                 710                 715                 720 


Xaa Arg Val Gln Lys Glu Asn 
                725         


<210> 2389
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(62)
<223> Selenocysteine

<400> 2389
Xaa Gly Asp Xaa Cys Leu His Val Ala Ala Arg Tyr Asn His Leu Ser 
1               5                   10                  15      


Ile Ile Arg Leu Leu Leu Xaa Ala Phe Cys Ser Val His Glu Lys Asn 
            20                  25                  30          


Gln Ala Gly Asp Xaa Ala Leu His Val Ala Ala Ala Leu Asn His Lys 
        35                  40                  45              


Lys Val Ala Lys Ile Leu Leu Glu Ala Gly Ala Asp Xaa Xaa Ile Val 
    50                  55                  60                  


Asn Asn Leu Pro Asp Cys Ser Glu His Asn Leu Ala 
65                  70                  75      


<210> 2390
<211> 152
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<400> 2390
Xaa His Arg Cys Ser Ser Pro Pro Pro Pro His Glu Phe Arg Ala Tyr 
1               5                   10                  15      


Gln Leu Tyr Xaa Leu Tyr Arg Gly Lys Asp Gly Lys Val Met Gln Met 
            20                  25                  30          


Arg Val Leu Asp Lys Leu Met Val Glu Arg Leu Ser Ala Glu Arg Xaa 
        35                  40                  45              


Glu Cys Leu Asn Arg Leu Gln Gln His Ser Asp Xaa Glu Lys His Glu 
    50                  55                  60                  


Gly Glu Lys Arg Gln Ile Ser Leu Val Asp Glu Leu Lys Xaa Trp Cys 
65                  70                  75                  80  


Met Leu Lys Ile Gln Asn Leu Glu Gln Lys Leu Ser Gly Asp Ser Arg 
                85                  90                  95      


Ala Cys Arg Ala Lys Ser Xaa Pro Ser Xaa Cys Glu Ser Ser Xaa Gly 
            100                 105                 110         


Val Asp Gln Leu Val Val Xaa Ala Gly Pro Ala Ala Ala Ser Asp Ser 
        115                 120                 125             


Ser Pro Pro Val Val Arg Pro Lys Glu Lys Ala Leu Asn Ser Xaa Ala 
    130                 135                 140                 


Xaa Gln Arg Leu Gln Gln Glu Leu 
145                 150         


<210> 2391
<211> 1134
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<400> 2391
Met Gly Lys Glu Gln Glu Leu Leu Glu Ala Ala Arg Xaa Gly His Leu 
1               5                   10                  15      


Pro Ala Val Glu Lys Leu Leu Ser Gly Lys Arg Leu Ser Ser Gly Phe 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Leu Gly Ser Ser Ser His Pro Leu Ser Ser Leu 
    50                  55                  60                  


Leu Ser Met Trp Arg Gly Pro Asn Val Asn Cys Val Asp Ser Xaa Gly 
65                  70                  75                  80  


Tyr Xaa Pro Leu His His Ala Ala Leu Asn Gly His Lys Asp Val Val 
                85                  90                  95      


Glu Val Leu Leu Arg Asn Asp Ala Leu Xaa Asn Val Ala Asp Ser Lys 
            100                 105                 110         


Gly Cys Tyr Pro Leu His Leu Ala Ala Trp Lys Gly Asp Ala Gln Ile 
        115                 120                 125             


Val Arg Leu Leu Ile His Gln Gly Pro Ser His Xaa Arg Val Asn Glu 
    130                 135                 140                 


Gln Asn Asn Asp Asn Glu Xaa Ala Leu His Cys Ala Ala Gln Tyr Gly 
145                 150                 155                 160 


His Xaa Glu Val Val Lys Val Leu Leu Glu Glu Leu Xaa Asp Pro Xaa 
                165                 170                 175     


Met Arg Asn Asn Lys Phe Glu Xaa Pro Leu Asp Leu Ala Ala Leu Tyr 
            180                 185                 190         


Gly Arg Leu Glu Val Val Lys Met Leu Leu Asn Ala His Pro Asn Leu 
        195                 200                 205             


Leu Ser Cys Asn Xaa Lys Lys His Xaa Pro Leu His Leu Ala Ala Arg 
    210                 215                 220                 


Asn Gly His Lys Ala Val Val Gln Val Leu Leu Asp Ala Gly Met Asp 
225                 230                 235                 240 


Ser Asn Tyr Gln Xaa Glu Met Gly Ser Ala Leu His Glu Ala Ala Leu 
                245                 250                 255     


Phe Gly Lys Xaa Asp Val Val Gln Ile Leu Leu Ala Ala Gly Xaa Asp 
            260                 265                 270         


Val Asn Ile Lys Asp Asn His Gly Leu Xaa Ala Leu Asp Xaa Val Arg 
        275                 280                 285             


Glu Leu Pro Ser Gln Lys Ser Gln Gln Ile Ala Ala Leu Ile Glu Asp 
    290                 295                 300                 


His Met Xaa Gly Lys Arg Ser Xaa Lys Glu Val Asp Lys Xaa Pro Pro 
305                 310                 315                 320 


Pro Gln Pro Pro Leu Ile Ser Ser Met Asp Ser Ile Ser Gln Lys Ser 
                325                 330                 335     


Gln Gly Asp Val Glu Lys Ala Val Xaa Glu Leu Ile Ile Asp Phe Asp 
            340                 345                 350         


Ala Asn Ala Glu Glu Glu Gly Pro Tyr Glu Ala Leu Tyr Asn Ala Ile 
        355                 360                 365             


Ser Cys His Ser Leu Asp Ser Met Ala Ser Gly Arg Ser Ser Asp Gln 
    370                 375                 380                 


Asp Ser Xaa Asn Lys Glu Ala Glu Ala Ala Gly Val Lys Pro Ala Gly 
385                 390                 395                 400 


Val Arg Pro Arg Glu Arg Pro Pro Pro Pro Ala Lys Pro Pro Pro Asp 
                405                 410                 415     


Glu Glu Glu Glu Asp His Ile Asp Lys Lys Tyr Phe Pro Leu Xaa Ala 
            420                 425                 430         


Ser Glu Val Leu Ser Met Arg Pro Arg Ile His Gly Ser Ala Ala Arg 
        435                 440                 445             


Glu Glu Asp Glu His Pro Tyr Glu Leu Leu Leu Xaa Ala Glu Xaa Lys 
    450                 455                 460                 


Lys Val Val Leu Val Asp Gly Lys Xaa Lys Asp His Arg Arg Ser Ser 
465                 470                 475                 480 


Ser Ser Arg Ser Gln Asp Ser Ala Glu Gly Gln Asp Gly Gln Val Pro 
                485                 490                 495     


Glu Gln Phe Ser Gly Leu Leu His Gly Ser Ser Pro Val Cys Glu Val 
            500                 505                 510         


Gly Gln Asp Pro Phe Gln Leu Leu Cys Xaa Ala Gly Gln Ser His Pro 
        515                 520                 525             


Asp Gly Ser Pro Gln Gln Gly Ala Cys His Lys Ala Ser Met Gln Leu 
    530                 535                 540                 


Glu Glu Xaa Gly Val His Ala Pro Gly Ala Ser Gln Pro Ser Ala Leu 
545                 550                 555                 560 


Asp Gln Ser Lys Arg Val Gly Tyr Leu Xaa Gly Leu Pro Xaa Xaa Asn 
                565                 570                 575     


Ser Arg Ser His Pro Glu Xaa Leu Xaa His Xaa Ala Ser Pro His Pro 
            580                 585                 590         


Gly Gly Ala Glu Glu Gly Asp Arg Ser Gly Ala Arg Ser Arg Ala Pro 
        595                 600                 605             


Pro Xaa Ser Lys Pro Lys Ala Glu Leu Lys Leu Ser Arg Ser Leu Ser 
    610                 615                 620                 


Lys Ser Asp Ser Asp Leu Leu Xaa Cys Ser Pro Xaa Glu Asp Ala Xaa 
625                 630                 635                 640 


Met Gly Ser Arg Ser Glu Ser Leu Ser Asn Cys Ser Ile Gly Lys Lys 
                645                 650                 655     


Arg Leu Glu Lys Ser Pro Ser Phe Ala Ser Glu Trp Asp Glu Ile Glu 
            660                 665                 670         


Lys Ile Met Ser Ser Ile Gly Glu Gly Ile Asp Phe Ser Gln Glu Arg 
        675                 680                 685             


Gln Lys Ile Ser Gly Leu Arg Xaa Leu Glu Gln Ser Val Gly Glu Trp 
    690                 695                 700                 


Leu Glu Ser Ile Gly Leu Gln Gln Tyr Glu Ser Lys Leu Leu Leu Asn 
705                 710                 715                 720 


Gly Phe Asp Asp Val His Phe Leu Gly Ser Asn Val Met Glu Glu Gln 
                725                 730                 735     


Asp Leu Arg Asp Ile Gly Ile Ser Asp Pro Gln His Arg Arg Lys Leu 
            740                 745                 750         


Leu Gln Ala Ala Arg Ser Leu Pro Lys Val Lys Ala Leu Gly Tyr Asp 
        755                 760                 765             


Gly Asn Ser Pro Pro Ser Val Pro Ser Trp Leu Asp Ser Leu Gly Leu 
    770                 775                 780                 


Gln Asp Tyr Val His Ser Phe Leu Ser Ser Gly Tyr Ser Ser Ile Asp 
785                 790                 795                 800 


Xaa Val Lys Asn Leu Trp Glu Leu Glu Leu Val Asn Val Leu Lys Val 
                805                 810                 815     


Gln Leu Leu Gly His Arg Lys Arg Ile Ile Ala Ser Leu Ala Asp Arg 
            820                 825                 830         


Pro Tyr Glu Glu Pro Pro Gln Lys Pro Pro Arg Phe Ser Gln Leu Arg 
        835                 840                 845             


Cys Gln Asp Leu Leu Ser Gln Xaa Ser Ser Pro Leu Ser Gln Asn Asp 
    850                 855                 860                 


Ser Cys Xaa Gly Arg Ser Ala Asp Leu Leu Leu Pro Pro Gly Asp Xaa 
865                 870                 875                 880 


Gly Arg Arg Arg His Asp Ser Leu His Asp Pro Ala Ala Pro Ser Arg 
                885                 890                 895     


Ala Glu Arg Phe Arg Ile Gln Glu Glu His Arg Glu Ala Lys Leu Xaa 
            900                 905                 910         


Leu Arg Pro Pro Ser Leu Ala Ala Pro Tyr Ala Pro Val Gln Ser Trp 
        915                 920                 925             


Gln His Gln Pro Glu Lys Leu Ile Phe Glu Ser Cys Gly Tyr Glu Ala 
    930                 935                 940                 


Asn Tyr Leu Gly Ser Met Leu Ile Lys Asp Leu Arg Gly Xaa Glu Ser 
945                 950                 955                 960 


Xaa Gln Asp Ala Cys Ala Lys Met Arg Lys Ser Xaa Glu His Met Lys 
                965                 970                 975     


Lys Ile Pro Xaa Ile Ile Leu Ser Ile Xaa Tyr Lys Gly Val Lys Phe 
            980                 985                 990         


Ile Asp Ala Ser Asn Lys Asn Val  Ile Ala Glu His Glu  Ile Arg Asn 
        995                 1000                 1005             


Ile Ser  Cys Ala Ala Gln Asp  Pro Glu Asp Leu Cys  Xaa Phe Ala 
    1010                 1015                 1020             


Tyr Ile  Xaa Lys Asp Leu Gln  Xaa Ser His His Tyr  Cys His Val 
    1025                 1030                 1035             


Phe Ser  Xaa Val Asp Val Asn  Leu Xaa Tyr Glu Ile  Ile Leu Xaa 
    1040                 1045                 1050             


Leu Gly  Gln Ala Phe Glu Val  Ala Tyr Gln Leu Ala  Leu Gln Ala 
    1055                 1060                 1065             


Gln Lys  Ser Arg Ala Xaa Gly  Ala Ser Ala Ala Glu  Met Ile Glu 
    1070                 1075                 1080             


Xaa Lys  Ser Ser Lys Pro Val  Pro Lys Pro Arg Val  Gly Val Arg 
    1085                 1090                 1095             


Lys Ser  Ala Leu Glu Pro Pro  Asp Met Asp Gln Asp  Ala Gln Ser 
    1100                 1105                 1110             


His Ala  Ser Val Ser Trp Val  Val Asp Pro Lys Pro  Asp Ser Lys 
    1115                 1120                 1125             


Arg Ser  Leu Ser Xaa Asn 
    1130                 


<210> 2392
<211> 840
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<400> 2392
Met Asp Tyr His Glu Asp Asp Lys Arg Phe Arg Arg Glu Glu Tyr Glu 
1               5                   10                  15      


Gly Asn Leu Leu Glu Ala Gly Leu Glu Leu Glu Arg Asp Glu Asp Xaa 
            20                  25                  30          


Lys Ile His Gly Val Gly Phe Val Lys Ile His Ala Pro Trp Asn Val 
        35                  40                  45              


Leu Cys Arg Glu Ala Glu Phe Leu Lys Leu Lys Met Pro Xaa Lys Lys 
    50                  55                  60                  


Met Tyr His Ile Asn Glu Xaa Arg Gly Leu Leu Lys Lys Ile Asn Ser 
65                  70                  75                  80  


Val Leu Gln Lys Ile Xaa Asp Pro Ile Gln Pro Lys Val Ala Glu His 
                85                  90                  95      


Arg Pro Gln Xaa Met Lys Arg Leu Ser Tyr Pro Phe Ser Arg Glu Lys 
            100                 105                 110         


Gln His Leu Phe Asp Leu Ser Asp Lys Asp Ser Phe Phe Asp Ser Lys 
        115                 120                 125             


Xaa Arg Ser Xaa Ile Val Tyr Glu Ile Leu Lys Arg Xaa Xaa Cys Xaa 
    130                 135                 140                 


Lys Ala Lys Tyr Ser Met Gly Ile Xaa Ser Leu Leu Ala Asn Gly Val 
145                 150                 155                 160 


Tyr Ala Ala Ala Tyr Pro Leu His Asp Gly Asp Tyr Asn Gly Glu Asn 
                165                 170                 175     


Val Glu Phe Asn Asp Arg Lys Leu Leu Tyr Glu Glu Trp Ala Arg Tyr 
            180                 185                 190         


Gly Val Phe Tyr Lys Tyr Gln Pro Ile Asp Leu Val Arg Lys Tyr Phe 
        195                 200                 205             


Gly Glu Lys Ile Gly Leu Tyr Phe Ala Trp Leu Gly Val Tyr Xaa Gln 
    210                 215                 220                 


Met Leu Ile Pro Ala Ser Ile Val Gly Ile Ile Val Phe Leu Tyr Gly 
225                 230                 235                 240 


Cys Ala Xaa Met Asp Glu Asn Ile Pro Ser Met Glu Met Cys Asp Gln 
                245                 250                 255     


Arg His Asn Ile Xaa Met Cys Pro Leu Cys Asp Lys Xaa Cys Ser Tyr 
            260                 265                 270         


Trp Lys Met Ser Ser Ala Cys Ala Xaa Ala Arg Ala Ser His Leu Phe 
        275                 280                 285             


Asp Asn Pro Ala Xaa Val Phe Phe Ser Val Phe Met Ala Leu Trp Ala 
    290                 295                 300                 


Ala Xaa Phe Met Glu His Trp Lys Arg Lys Gln Met Arg Leu Asn Tyr 
305                 310                 315                 320 


Arg Trp Asp Leu Xaa Gly Phe Glu Glu Glu Glu Asp His Pro Arg Ala 
                325                 330                 335     


Glu Tyr Glu Ala Arg Val Leu Glu Lys Ser Leu Lys Lys Glu Ser Arg 
            340                 345                 350         


Asn Lys Glu Xaa Asp Lys Val Lys Leu Xaa Trp Arg Asp Arg Phe Pro 
        355                 360                 365             


Ala Tyr Leu Xaa Asn Leu Val Ser Ile Ile Phe Met Ile Ala Val Xaa 
    370                 375                 380                 


Phe Ala Ile Val Leu Gly Val Ile Ile Tyr Arg Ile Ser Met Ala Ala 
385                 390                 395                 400 


Ala Leu Ala Met Asn Ser Ser Pro Ser Val Arg Ser Asn Ile Arg Val 
                405                 410                 415     


Xaa Val Xaa Ala Xaa Ala Val Ile Ile Asn Leu Val Val Ile Ile Leu 
            420                 425                 430         


Leu Asp Glu Val Tyr Gly Cys Ile Ala Arg Trp Leu Xaa Lys Ile Glu 
        435                 440                 445             


Val Pro Lys Xaa Glu Lys Ser Phe Glu Glu Arg Leu Ile Phe Lys Ala 
    450                 455                 460                 


Phe Leu Leu Lys Phe Val Asn Ser Tyr Xaa Pro Ile Phe Tyr Val Ala 
465                 470                 475                 480 


Phe Phe Lys Gly Arg Phe Val Gly Arg Pro Gly Asp Tyr Val Tyr Ile 
                485                 490                 495     


Phe Arg Ser Phe Arg Met Glu Glu Cys Ala Pro Gly Gly Cys Leu Met 
            500                 505                 510         


Glu Leu Cys Ile Gln Leu Ser Ile Ile Met Leu Gly Lys Gln Leu Ile 
        515                 520                 525             


Gln Asn Asn Leu Phe Glu Ile Gly Ile Pro Lys Met Lys Lys Leu Ile 
    530                 535                 540                 


Arg Tyr Leu Lys Leu Lys Gln Gln Ser Pro Pro Asp His Glu Glu Cys 
545                 550                 555                 560 


Val Lys Arg Lys Gln Arg Tyr Glu Val Asp Tyr Asn Leu Glu Pro Phe 
                565                 570                 575     


Ala Gly Leu Xaa Pro Glu Tyr Met Glu Met Ile Ile Gln Phe Gly Phe 
            580                 585                 590         


Val Xaa Leu Phe Val Ala Ser Phe Pro Leu Ala Pro Leu Phe Ala Leu 
        595                 600                 605             


Leu Asn Asn Ile Ile Glu Ile Arg Leu Asp Ala Lys Lys Phe Val Xaa 
    610                 615                 620                 


Glu Leu Arg Arg Pro Val Ala Val Arg Ala Lys Asp Ile Gly Ile Trp 
625                 630                 635                 640 


Tyr Asn Ile Leu Arg Gly Ile Gly Lys Leu Ala Val Ile Ile Asn Ala 
                645                 650                 655     


Phe Val Ile Ser Phe Xaa Ser Asp Phe Ile Pro Arg Leu Val Tyr Leu 
            660                 665                 670         


Tyr Met Tyr Ser Lys Asn Gly Xaa Met His Gly Phe Val Asn His Xaa 
        675                 680                 685             


Leu Ser Ser Phe Asn Val Ser Asp Phe Gln Asn Gly Xaa Ala Pro Asn 
    690                 695                 700                 


Asp Pro Leu Asp Leu Gly Tyr Glu Val Gln Ile Cys Arg Tyr Lys Asp 
705                 710                 715                 720 


Tyr Arg Glu Pro Pro Trp Ser Glu Asn Lys Tyr Asp Ile Ser Lys Asp 
                725                 730                 735     


Phe Trp Ala Val Leu Ala Ala Arg Leu Ala Phe Val Ile Val Phe Gln 
            740                 745                 750         


Asn Leu Val Met Phe Met Ser Asp Phe Val Asp Trp Val Ile Pro Asp 
        755                 760                 765             


Ile Pro Lys Asp Ile Ser Gln Gln Ile His Lys Glu Lys Val Leu Met 
    770                 775                 780                 


Val Glu Leu Phe Met Arg Glu Glu Gln Asp Lys Gln Gln Leu Leu Glu 
785                 790                 795                 800 


Xaa Trp Met Glu Lys Glu Arg Gln Lys Asp Glu Pro Pro Cys Asn His 
                805                 810                 815     


His Asn Xaa Lys Ala Cys Pro Asp Ser Leu Gly Ser Pro Ala Pro Ser 
            820                 825                 830         


His Ala Tyr His Gly Gly Val Leu 
        835                 840 


<210> 2393
<211> 151
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<400> 2393
Met Glu His Trp Lys Arg Lys Gln Met Arg Leu Asn Tyr Arg Trp Asp 
1               5                   10                  15      


Leu Xaa Gly Phe Glu Glu Glu Glu Glu Ala Val Lys Asp His Pro Arg 
            20                  25                  30          


Ala Glu Tyr Glu Ala Arg Val Leu Glu Lys Ser Leu Lys Lys Glu Ser 
        35                  40                  45              


Arg Asn Lys Glu Xaa Asp Lys Val Lys Leu Xaa Trp Arg Asp Arg Phe 
    50                  55                  60                  


Pro Ala Tyr Leu Xaa Asn Leu Val Ser Ile Ile Phe Met Ile Ala Val 
65                  70                  75                  80  


Xaa Phe Ala Ile Val Leu Gly Val Ile Ile Tyr Arg Ile Ser Met Ala 
                85                  90                  95      


Ala Ala Leu Ala Met Asn Ser Ser Pro Ser Val Arg Ser Asn Ile Arg 
            100                 105                 110         


Val Xaa Val Xaa Ala Xaa Ala Val Ile Ile Asn Leu Val Val Ile Ile 
        115                 120                 125             


Leu Leu Asp Glu Val Tyr Gly Cys Ile Ala Arg Trp Leu Xaa Lys Ile 
    130                 135                 140                 


Glu Val Pro Lys Xaa Glu Lys 
145                 150     


<210> 2394
<211> 695
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<400> 2394
Met Gly Ile Xaa Ser Leu Leu Ala Asn Gly Val Tyr Ala Ala Ala Tyr 
1               5                   10                  15      


Pro Leu His Asp Gly Asp Tyr Asn Gly Glu Asn Val Glu Phe Asn Asp 
            20                  25                  30          


Arg Lys Leu Leu Tyr Glu Glu Trp Ala Arg Tyr Gly Val Phe Tyr Lys 
        35                  40                  45              


Tyr Gln Pro Ile Asp Leu Val Arg Lys Tyr Phe Gly Glu Lys Ile Gly 
    50                  55                  60                  


Leu Tyr Phe Ala Trp Leu Gly Val Tyr Xaa Gln Met Leu Ile Pro Ala 
65                  70                  75                  80  


Ser Ile Val Gly Ile Ile Val Phe Leu Tyr Gly Cys Ala Xaa Met Asp 
                85                  90                  95      


Glu Asn Ile Pro Ser Met Glu Met Cys Asp Gln Arg His Asn Ile Xaa 
            100                 105                 110         


Met Cys Pro Leu Cys Asp Lys Xaa Cys Ser Tyr Trp Lys Met Ser Ser 
        115                 120                 125             


Ala Cys Ala Xaa Ala Arg Ala Ser His Leu Phe Asp Asn Pro Ala Xaa 
    130                 135                 140                 


Val Phe Phe Ser Val Phe Met Ala Leu Trp Ala Ala Xaa Phe Met Glu 
145                 150                 155                 160 


His Trp Lys Arg Lys Gln Met Arg Leu Asn Tyr Arg Trp Asp Leu Xaa 
                165                 170                 175     


Gly Phe Glu Glu Glu Glu Glu Ala Val Lys Asp His Pro Arg Ala Glu 
            180                 185                 190         


Tyr Glu Ala Arg Val Leu Glu Lys Ser Leu Lys Lys Glu Ser Arg Asn 
        195                 200                 205             


Lys Glu Xaa Asp Lys Val Lys Leu Xaa Trp Arg Asp Arg Phe Pro Ala 
    210                 215                 220                 


Tyr Leu Xaa Asn Leu Val Ser Ile Ile Phe Met Ile Ala Val Xaa Phe 
225                 230                 235                 240 


Ala Ile Val Leu Gly Val Ile Ile Tyr Arg Ile Ser Met Ala Ala Ala 
                245                 250                 255     


Leu Ala Met Asn Ser Ser Pro Ser Val Arg Ser Asn Ile Arg Val Xaa 
            260                 265                 270         


Val Xaa Ala Xaa Ala Val Ile Ile Asn Leu Val Val Ile Ile Leu Leu 
        275                 280                 285             


Asp Glu Val Tyr Gly Cys Ile Ala Arg Trp Leu Xaa Lys Ile Glu Val 
    290                 295                 300                 


Pro Lys Xaa Glu Lys Ser Phe Glu Glu Arg Leu Ile Phe Lys Ala Phe 
305                 310                 315                 320 


Leu Leu Lys Phe Val Asn Ser Tyr Xaa Pro Ile Phe Tyr Val Ala Phe 
                325                 330                 335     


Phe Lys Gly Arg Phe Val Gly Arg Pro Gly Asp Tyr Val Tyr Ile Phe 
            340                 345                 350         


Arg Ser Phe Arg Met Glu Glu Cys Ala Pro Gly Gly Cys Leu Met Glu 
        355                 360                 365             


Leu Cys Ile Gln Leu Ser Ile Ile Met Leu Gly Lys Gln Leu Ile Gln 
    370                 375                 380                 


Asn Asn Leu Phe Glu Ile Gly Ile Pro Lys Met Lys Lys Leu Ile Arg 
385                 390                 395                 400 


Tyr Leu Lys Leu Lys Gln Gln Ser Pro Pro Asp His Glu Glu Cys Val 
                405                 410                 415     


Lys Arg Lys Gln Arg Tyr Glu Val Asp Tyr Asn Leu Glu Pro Phe Ala 
            420                 425                 430         


Gly Leu Xaa Pro Glu Tyr Met Glu Met Ile Ile Gln Phe Gly Phe Val 
        435                 440                 445             


Xaa Leu Phe Val Ala Ser Phe Pro Leu Ala Pro Leu Phe Ala Leu Leu 
    450                 455                 460                 


Asn Asn Ile Ile Glu Ile Arg Leu Asp Ala Lys Lys Phe Val Xaa Glu 
465                 470                 475                 480 


Leu Arg Arg Pro Val Ala Val Arg Ala Lys Asp Ile Gly Ile Trp Tyr 
                485                 490                 495     


Asn Ile Leu Arg Gly Ile Gly Lys Leu Ala Val Ile Ile Asn Ala Phe 
            500                 505                 510         


Val Ile Ser Phe Xaa Ser Asp Phe Ile Pro Arg Leu Val Tyr Leu Tyr 
        515                 520                 525             


Met Tyr Ser Lys Asn Gly Xaa Met His Gly Phe Val Asn His Xaa Leu 
    530                 535                 540                 


Ser Ser Phe Asn Val Ser Asp Phe Gln Asn Gly Xaa Ala Pro Asn Asp 
545                 550                 555                 560 


Pro Leu Asp Leu Gly Tyr Glu Val Gln Ile Cys Arg Tyr Lys Asp Tyr 
                565                 570                 575     


Arg Glu Pro Pro Trp Ser Glu Asn Lys Tyr Asp Ile Ser Lys Asp Phe 
            580                 585                 590         


Trp Ala Val Leu Ala Ala Arg Leu Ala Phe Val Ile Val Phe Gln Asn 
        595                 600                 605             


Leu Val Met Phe Met Ser Asp Phe Val Asp Trp Val Ile Pro Asp Ile 
    610                 615                 620                 


Pro Lys Asp Ile Ser Gln Gln Ile His Lys Glu Lys Val Leu Met Val 
625                 630                 635                 640 


Glu Leu Phe Met Arg Glu Glu Gln Asp Lys Gln Gln Leu Leu Glu Xaa 
                645                 650                 655     


Trp Met Glu Lys Glu Arg Gln Lys Asp Glu Pro Pro Cys Asn His His 
            660                 665                 670         


Asn Xaa Lys Ala Cys Pro Asp Ser Leu Gly Ser Pro Ala Pro Ser His 
        675                 680                 685             


Ala Tyr His Gly Gly Val Leu 
    690                 695 


<210> 2395
<211> 642
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<400> 2395
Met Leu Xaa Arg Pro Ser Gln Val Leu Leu Asn Ser Leu Ser Val Asp 
1               5                   10                  15      


Pro Asp Ala Glu Cys Lys Tyr Gly Leu Tyr Phe Arg Asp Gly Arg Arg 
            20                  25                  30          


Lys Val Asp Tyr Ile Leu Val Tyr His His Lys Arg Pro Ser Gly Asn 
        35                  40                  45              


Arg Xaa Leu Val Arg Arg Val Gln His Ser Asp Xaa Pro Ser Gly Ala 
    50                  55                  60                  


Arg Ser Val Lys Gln Asp His Pro Leu Pro Gly Lys Gly Ala Ser Leu 
65                  70                  75                  80  


Asp Ala Gly Ser Gly Glu Pro Pro Met Asp Tyr His Glu Asp Asp Lys 
                85                  90                  95      


Arg Phe Arg Arg Glu Glu Tyr Glu Gly Asn Leu Leu Glu Ala Gly Leu 
            100                 105                 110         


Glu Leu Glu Arg Asp Glu Asp Xaa Lys Ile His Gly Val Gly Phe Val 
        115                 120                 125             


Lys Ile His Ala Pro Trp Asn Val Leu Cys Arg Glu Ala Glu Phe Leu 
    130                 135                 140                 


Lys Leu Lys Met Pro Xaa Lys Lys Met Tyr His Ile Asn Glu Xaa Arg 
145                 150                 155                 160 


Gly Leu Leu Lys Lys Ile Asn Ser Val Leu Gln Lys Ile Xaa Asp Pro 
                165                 170                 175     


Ile Gln Pro Lys Val Ala Glu His Arg Pro Gln Xaa Met Lys Arg Leu 
            180                 185                 190         


Ser Tyr Pro Phe Ser Arg Glu Lys Gln His Leu Phe Asp Leu Ser Asp 
        195                 200                 205             


Lys Asp Ser Phe Phe Asp Ser Lys Xaa Arg Ser Xaa Ile Val Tyr Glu 
    210                 215                 220                 


Ile Leu Lys Arg Xaa Xaa Cys Xaa Lys Ala Lys Tyr Ser Met Gly Ile 
225                 230                 235                 240 


Xaa Ser Leu Leu Ala Asn Gly Val Tyr Ala Ala Ala Tyr Pro Leu His 
                245                 250                 255     


Asp Gly Asp Tyr Asn Gly Glu Asn Val Glu Phe Asn Asp Arg Lys Leu 
            260                 265                 270         


Leu Tyr Glu Glu Trp Ala Arg Tyr Gly Val Phe Tyr Lys Tyr Gln Pro 
        275                 280                 285             


Ile Asp Leu Val Arg Lys Tyr Phe Gly Glu Lys Ile Gly Leu Tyr Phe 
    290                 295                 300                 


Ala Trp Leu Gly Val Tyr Xaa Gln Met Leu Ile Pro Ala Ser Ile Val 
305                 310                 315                 320 


Gly Ile Ile Val Phe Leu Tyr Gly Cys Ala Xaa Met Asp Glu Asn Ile 
                325                 330                 335     


Pro Ser Met Glu Met Cys Asp Gln Arg His Asn Ile Xaa Met Cys Pro 
            340                 345                 350         


Leu Cys Asp Lys Xaa Cys Ser Tyr Trp Lys Met Ser Ser Ala Cys Ala 
        355                 360                 365             


Xaa Ala Arg Ala Ser His Leu Phe Asp Asn Pro Ala Xaa Val Phe Phe 
    370                 375                 380                 


Ser Val Phe Met Ala Leu Trp Ala Ala Xaa Phe Met Glu His Trp Lys 
385                 390                 395                 400 


Arg Lys Gln Met Arg Leu Asn Tyr Arg Trp Asp Leu Xaa Gly Phe Glu 
                405                 410                 415     


Glu Glu Glu Asp His Pro Arg Ala Glu Tyr Glu Ala Arg Val Leu Glu 
            420                 425                 430         


Lys Ser Leu Lys Lys Glu Ser Arg Asn Lys Glu Xaa Asp Lys Val Lys 
        435                 440                 445             


Leu Xaa Trp Arg Asp Arg Phe Pro Ala Tyr Leu Xaa Asn Leu Val Ser 
    450                 455                 460                 


Ile Ile Phe Met Ile Ala Val Xaa Phe Ala Ile Val Leu Gly Val Ile 
465                 470                 475                 480 


Ile Tyr Arg Ile Ser Met Ala Ala Ala Leu Ala Met Asn Ser Ser Pro 
                485                 490                 495     


Ser Val Arg Ser Asn Ile Arg Val Xaa Val Xaa Ala Xaa Ala Val Ile 
            500                 505                 510         


Ile Asn Leu Val Val Ile Ile Leu Leu Asp Glu Val Tyr Gly Cys Ile 
        515                 520                 525             


Ala Arg Trp Leu Xaa Lys Ile Glu Val Pro Lys Xaa Glu Lys Ser Phe 
    530                 535                 540                 


Glu Glu Arg Leu Ile Phe Lys Ala Phe Leu Leu Lys Phe Val Asn Ser 
545                 550                 555                 560 


Tyr Xaa Pro Ile Phe Tyr Val Ala Phe Phe Lys Gly Arg Phe Val Gly 
                565                 570                 575     


Arg Pro Gly Asp Tyr Val Tyr Ile Phe Arg Ser Phe Arg Met Glu Glu 
            580                 585                 590         


Val Xaa Glu Ile Leu Phe Ile Ser Gly Ser Pro Phe Cys Leu Ala Tyr 
        595                 600                 605             


Asp Leu Ser Xaa Pro Cys Xaa Trp Glu Lys Gln Leu Gln His Ile Cys 
    610                 615                 620                 


Ser Ala Lys Ser Ser Arg Phe Leu Ser Phe Leu Leu Glu Xaa Phe Leu 
625                 630                 635                 640 


Phe Pro 
        


<210> 2396
<211> 251
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<400> 2396
Met Arg Val Asn Glu Lys Tyr Ser Xaa Leu Pro Ala Glu Asp Arg Ser 
1               5                   10                  15      


Val His Ile Ile Asn Ile Cys Ala Ile Glu Asp Ile Gly Tyr Leu Pro 
            20                  25                  30          


Ser Glu Gly Xaa Leu Leu Asn Ser Leu Ser Val Asp Pro Asp Ala Glu 
        35                  40                  45              


Cys Lys Tyr Gly Leu Tyr Phe Arg Asp Gly Arg Arg Lys Val Asp Tyr 
    50                  55                  60                  


Ile Leu Val Tyr His His Lys Arg Pro Ser Gly Asn Arg Xaa Leu Val 
65                  70                  75                  80  


Arg Arg Val Gln His Ser Asp Xaa Pro Ser Gly Ala Arg Ser Val Lys 
                85                  90                  95      


Gln Asp His Pro Leu Pro Gly Lys Gly Ala Ser Leu Asp Ala Gly Ser 
            100                 105                 110         


Gly Glu Pro Pro Met Asp Tyr His Glu Asp Asp Lys Arg Phe Arg Arg 
        115                 120                 125             


Glu Glu Tyr Glu Gly Asn Leu Leu Glu Ala Gly Leu Glu Leu Glu Arg 
    130                 135                 140                 


Asp Glu Asp Met Tyr His Ile Asn Glu Xaa Arg Gly Leu Leu Lys Lys 
145                 150                 155                 160 


Ile Asn Ser Val Leu Gln Lys Ile Xaa Asp Pro Ile Gln Pro Lys Val 
                165                 170                 175     


Ala Glu His Arg Pro Gln Xaa Met Lys Arg Leu Ser Tyr Pro Phe Ser 
            180                 185                 190         


Arg Glu Lys Gln His Leu Phe Asp Leu Ser Asp Lys Asp Ser Phe Phe 
        195                 200                 205             


Asp Ser Lys Xaa Arg Ser Xaa Ile Val Tyr Glu Ile Leu Lys Arg Xaa 
    210                 215                 220                 


Xaa Cys Xaa Lys Ala Lys Tyr Ser Met Gly Ile Xaa Ser Leu Leu Ala 
225                 230                 235                 240 


Asn Gly Val Tyr Ala Ala Ala Tyr Pro Leu His 
                245                 250     


<210> 2397
<211> 986
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<400> 2397
Met Arg Val Asn Glu Lys Tyr Ser Xaa Leu Pro Ala Glu Asp Arg Ser 
1               5                   10                  15      


Val His Ile Ile Asn Ile Cys Ala Ile Glu Asp Ile Gly Tyr Leu Pro 
            20                  25                  30          


Ser Glu Gly Xaa Leu Leu Asn Ser Leu Ser Val Asp Pro Asp Ala Glu 
        35                  40                  45              


Cys Lys Tyr Gly Leu Tyr Phe Arg Asp Gly Arg Arg Lys Val Asp Tyr 
    50                  55                  60                  


Ile Leu Val Tyr His His Lys Arg Pro Ser Gly Asn Arg Xaa Leu Val 
65                  70                  75                  80  


Arg Arg Val Gln His Ser Asp Xaa Pro Ser Gly Ala Arg Ser Val Lys 
                85                  90                  95      


Gln Asp His Pro Leu Pro Gly Lys Gly Ala Ser Leu Asp Ala Gly Ser 
            100                 105                 110         


Gly Glu Pro Pro Met Asp Tyr His Glu Asp Asp Lys Arg Phe Arg Arg 
        115                 120                 125             


Glu Glu Tyr Glu Gly Asn Leu Leu Glu Ala Gly Leu Glu Leu Glu Arg 
    130                 135                 140                 


Asp Glu Asp Xaa Lys Ile His Gly Val Gly Phe Val Lys Ile His Ala 
145                 150                 155                 160 


Pro Trp Asn Val Leu Cys Arg Glu Ala Glu Phe Leu Lys Leu Lys Met 
                165                 170                 175     


Pro Xaa Lys Lys Met Tyr His Ile Asn Glu Xaa Arg Gly Leu Leu Lys 
            180                 185                 190         


Lys Ile Asn Ser Val Leu Gln Lys Ile Xaa Asp Pro Ile Gln Pro Lys 
        195                 200                 205             


Val Ala Glu His Arg Pro Gln Xaa Met Lys Arg Leu Ser Tyr Pro Phe 
    210                 215                 220                 


Ser Arg Glu Lys Gln His Leu Phe Asp Leu Ser Asp Lys Asp Ser Phe 
225                 230                 235                 240 


Phe Asp Ser Lys Xaa Arg Ser Xaa Ile Val Tyr Glu Ile Leu Lys Arg 
                245                 250                 255     


Xaa Xaa Cys Xaa Lys Ala Lys Tyr Ser Met Gly Ile Xaa Ser Leu Leu 
            260                 265                 270         


Ala Asn Gly Val Tyr Ala Ala Ala Tyr Pro Leu His Asp Gly Asp Tyr 
        275                 280                 285             


Asn Gly Glu Asn Val Glu Phe Asn Asp Arg Lys Leu Leu Tyr Glu Glu 
    290                 295                 300                 


Trp Ala Arg Tyr Gly Val Phe Tyr Lys Tyr Gln Pro Ile Asp Leu Val 
305                 310                 315                 320 


Arg Lys Tyr Phe Gly Glu Lys Ile Gly Leu Tyr Phe Ala Trp Leu Gly 
                325                 330                 335     


Val Tyr Xaa Gln Met Leu Ile Pro Ala Ser Ile Val Gly Ile Ile Val 
            340                 345                 350         


Phe Leu Tyr Gly Cys Ala Xaa Met Asp Glu Asn Ile Pro Ser Met Glu 
        355                 360                 365             


Met Cys Asp Gln Arg His Asn Ile Xaa Met Cys Pro Leu Cys Asp Lys 
    370                 375                 380                 


Xaa Cys Ser Tyr Trp Lys Met Ser Ser Ala Cys Ala Xaa Ala Arg Ala 
385                 390                 395                 400 


Ser His Leu Phe Asp Asn Pro Ala Xaa Val Phe Phe Ser Val Phe Met 
                405                 410                 415     


Ala Leu Trp Ala Ala Xaa Phe Met Glu His Trp Lys Arg Lys Gln Met 
            420                 425                 430         


Arg Leu Asn Tyr Arg Trp Asp Leu Xaa Gly Phe Glu Glu Glu Glu Glu 
        435                 440                 445             


Ala Val Lys Asp His Pro Arg Ala Glu Tyr Glu Ala Arg Val Leu Glu 
    450                 455                 460                 


Lys Ser Leu Lys Lys Glu Ser Arg Asn Lys Glu Lys Arg Arg His Ile 
465                 470                 475                 480 


Pro Glu Glu Ser Xaa Asn Lys Trp Lys Gln Arg Val Lys Xaa Ala Met 
                485                 490                 495     


Ala Gly Val Lys Leu Xaa Asp Lys Val Lys Leu Xaa Trp Arg Asp Arg 
            500                 505                 510         


Phe Pro Ala Tyr Leu Xaa Asn Leu Val Ser Ile Ile Phe Met Ile Ala 
        515                 520                 525             


Val Xaa Phe Ala Ile Val Leu Gly Val Ile Ile Tyr Arg Ile Ser Met 
    530                 535                 540                 


Ala Ala Ala Leu Ala Met Asn Ser Ser Pro Ser Val Arg Ser Asn Ile 
545                 550                 555                 560 


Arg Val Xaa Val Xaa Ala Xaa Ala Val Ile Ile Asn Leu Val Val Ile 
                565                 570                 575     


Ile Leu Leu Asp Glu Val Tyr Gly Cys Ile Ala Arg Trp Leu Xaa Lys 
            580                 585                 590         


Ile Glu Val Pro Lys Xaa Glu Lys Ser Phe Glu Glu Arg Leu Ile Phe 
        595                 600                 605             


Lys Ala Phe Leu Leu Lys Phe Val Asn Ser Tyr Xaa Pro Ile Phe Tyr 
    610                 615                 620                 


Val Ala Phe Phe Lys Gly Arg Phe Val Gly Arg Pro Gly Asp Tyr Val 
625                 630                 635                 640 


Tyr Ile Phe Arg Ser Phe Arg Met Glu Glu Cys Ala Pro Gly Gly Cys 
                645                 650                 655     


Leu Met Glu Leu Cys Ile Gln Leu Ser Ile Ile Met Leu Gly Lys Gln 
            660                 665                 670         


Leu Ile Gln Asn Asn Leu Phe Glu Ile Gly Ile Pro Lys Met Lys Lys 
        675                 680                 685             


Leu Ile Arg Tyr Leu Lys Leu Lys Gln Gln Ser Pro Pro Asp His Glu 
    690                 695                 700                 


Glu Cys Val Lys Arg Lys Gln Arg Tyr Glu Val Asp Tyr Asn Leu Glu 
705                 710                 715                 720 


Pro Phe Ala Gly Leu Xaa Pro Glu Tyr Met Glu Met Ile Ile Gln Phe 
                725                 730                 735     


Gly Phe Val Xaa Leu Phe Val Ala Ser Phe Pro Leu Ala Pro Leu Phe 
            740                 745                 750         


Ala Leu Leu Asn Asn Ile Ile Glu Ile Arg Leu Asp Ala Lys Lys Phe 
        755                 760                 765             


Val Xaa Glu Leu Arg Arg Pro Val Ala Val Arg Ala Lys Asp Ile Gly 
    770                 775                 780                 


Ile Trp Tyr Asn Ile Leu Arg Gly Ile Gly Lys Leu Ala Val Ile Ile 
785                 790                 795                 800 


Asn Ala Phe Val Ile Ser Phe Xaa Ser Asp Phe Ile Pro Arg Leu Val 
                805                 810                 815     


Tyr Leu Tyr Met Tyr Ser Lys Asn Gly Xaa Met His Gly Phe Val Asn 
            820                 825                 830         


His Xaa Leu Ser Ser Phe Asn Val Ser Asp Phe Gln Asn Gly Xaa Ala 
        835                 840                 845             


Pro Asn Asp Pro Leu Asp Leu Gly Tyr Glu Val Gln Ile Cys Arg Tyr 
    850                 855                 860                 


Lys Asp Tyr Arg Glu Pro Pro Trp Ser Glu Asn Lys Tyr Asp Ile Ser 
865                 870                 875                 880 


Lys Asp Phe Trp Ala Val Leu Ala Ala Arg Leu Ala Phe Val Ile Val 
                885                 890                 895     


Phe Gln Asn Leu Val Met Phe Met Ser Asp Phe Val Asp Trp Val Ile 
            900                 905                 910         


Pro Asp Ile Pro Lys Asp Ile Ser Gln Gln Ile His Lys Glu Lys Val 
        915                 920                 925             


Leu Met Val Glu Leu Phe Met Arg Glu Glu Gln Asp Lys Gln Gln Leu 
    930                 935                 940                 


Leu Glu Xaa Trp Met Glu Lys Glu Arg Gln Lys Asp Glu Pro Pro Cys 
945                 950                 955                 960 


Asn His His Asn Xaa Lys Ala Cys Pro Asp Ser Leu Gly Ser Pro Ala 
                965                 970                 975     


Pro Ser His Ala Tyr His Gly Gly Val Leu 
            980                 985     


<210> 2398
<211> 269
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<400> 2398
Xaa His Ala Pro Trp Asn Val Leu Cys Arg Glu Ala Glu Phe Leu Lys 
1               5                   10                  15      


Leu Lys Met Pro Xaa Lys Lys Met Tyr His Ile Asn Glu Xaa Arg Gly 
            20                  25                  30          


Leu Leu Lys Lys Ile Asn Ser Val Leu Gln Lys Ile Xaa Asp Pro Ile 
        35                  40                  45              


Gln Pro Lys Val Ala Glu His Arg Pro Gln Xaa Met Lys Arg Leu Ser 
    50                  55                  60                  


Tyr Pro Phe Ser Arg Glu Lys Gln His Leu Phe Asp Leu Ser Asp Lys 
65                  70                  75                  80  


Asp Ser Phe Phe Asp Ser Lys Xaa Arg Ser Xaa Ile Val Tyr Glu Ile 
                85                  90                  95      


Leu Lys Arg Xaa Xaa Cys Xaa Lys Ala Lys Tyr Ser Met Gly Gln Gly 
            100                 105                 110         


Glu Gly Arg Lys Lys Asp Ser Ala Leu Leu Ser Lys Arg Arg Lys Cys 
        115                 120                 125             


Gly Lys Tyr Gly Ile Xaa Ser Leu Leu Ala Asn Gly Val Tyr Ala Ala 
    130                 135                 140                 


Ala Tyr Pro Leu His Asp Gly Asp Tyr Asn Gly Glu Asn Val Glu Phe 
145                 150                 155                 160 


Asn Asp Arg Lys Leu Leu Tyr Glu Glu Trp Ala Arg Tyr Gly Val Phe 
                165                 170                 175     


Tyr Lys Tyr Gln Pro Ile Asp Leu Val Arg Lys Tyr Phe Gly Glu Lys 
            180                 185                 190         


Ile Gly Leu Tyr Phe Ala Trp Leu Gly Val Tyr Xaa Gln Met Leu Ile 
        195                 200                 205             


Pro Ala Ser Ile Val Gly Ile Ile Val Phe Leu Tyr Gly Cys Ala Xaa 
    210                 215                 220                 


Met Asp Glu Asn Ile Pro Ser Met Glu Met Cys Asp Gln Arg His Asn 
225                 230                 235                 240 


Ile Xaa Met Cys Pro Leu Cys Asp Lys Xaa Cys Ser Tyr Trp Lys Met 
                245                 250                 255     


Ser Ser Ala Cys Ala Xaa Ala Arg Ala Ser His Leu Phe 
            260                 265                 


<210> 2399
<211> 892
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<400> 2399
Met Phe Cys Ala Ala Val Leu Glu Asn Leu Gly Gln Xaa Ile Val Pro 
1               5                   10                  15      


Asp Leu Gly Ser Leu Glu Ser Gln His Asp Phe Arg Xaa Pro Glu Phe 
            20                  25                  30          


Glu Glu Phe Asn Gly Lys Pro Asp Ser Leu Phe Phe Asn Asp Gly Gln 
        35                  40                  45              


Arg Arg Ile Asp Phe Val Leu Val Tyr Glu Asp Glu Ser Arg Lys Glu 
    50                  55                  60                  


Xaa Asn Lys Lys Gly Xaa Asn Glu Lys Gln Arg Arg Lys Arg Gln Ala 
65                  70                  75                  80  


Tyr Glu Ser Asn Leu Ile Cys His Gly Leu Gln Leu Glu Ala Xaa Arg 
                85                  90                  95      


Ser Val Leu Asp Asp Lys Leu Val Phe Val Lys Val His Ala Pro Trp 
            100                 105                 110         


Glu Val Leu Cys Xaa Tyr Ala Glu Ile Met His Ile Lys Leu Pro Leu 
        115                 120                 125             


Lys Pro Asn Asp Leu Lys Asn Arg Ser Ser Ala Phe Gly Xaa Leu Asn 
    130                 135                 140                 


Trp Phe Xaa Lys Val Leu Ser Val Asp Glu Ser Ile Ile Lys Pro Glu 
145                 150                 155                 160 


Gln Glu Phe Phe Xaa Ala Pro Phe Glu Lys Asn Arg Met Asn Asp Phe 
                165                 170                 175     


Tyr Ile Val Asp Arg Asp Ala Phe Phe Asn Pro Ala Xaa Arg Ser Arg 
            180                 185                 190         


Ile Val Tyr Phe Ile Leu Ser Arg Val Lys Tyr Gln Val Ile Asn Asn 
        195                 200                 205             


Val Ser Lys Phe Gly Ile Asn Arg Leu Val Asn Ser Gly Ile Tyr Lys 
    210                 215                 220                 


Ala Ala Phe Pro Leu His Asp Cys Lys Phe Arg Arg Gln Ser Glu Asp 
225                 230                 235                 240 


Pro Ser Cys Pro Asn Glu Arg Tyr Leu Leu Tyr Arg Glu Trp Ala His 
                245                 250                 255     


Pro Arg Ser Ile Tyr Lys Lys Gln Pro Leu Asp Leu Ile Arg Lys Tyr 
            260                 265                 270         


Tyr Gly Glu Lys Ile Gly Ile Tyr Phe Ala Trp Leu Gly Tyr Tyr Xaa 
        275                 280                 285             


Gln Met Leu Leu Leu Ala Ala Val Val Gly Val Ala Cys Phe Leu Tyr 
    290                 295                 300                 


Gly Tyr Leu Asn Gln Asp Asn Cys Xaa Trp Ser Lys Glu Val Cys His 
305                 310                 315                 320 


Pro Asp Ile Gly Gly Lys Ile Ile Met Cys Pro Gln Cys Asp Arg Leu 
                325                 330                 335     


Cys Pro Phe Trp Lys Leu Asn Ile Xaa Cys Glu Ser Ser Lys Lys Leu 
            340                 345                 350         


Cys Ile Phe Asp Ser Phe Gly Xaa Leu Val Phe Ala Val Phe Met Gly 
        355                 360                 365             


Val Trp Val Xaa Leu Phe Leu Glu Phe Trp Lys Arg Arg Gln Ala Glu 
    370                 375                 380                 


Leu Glu Tyr Glu Trp Asp Xaa Val Glu Leu Gln Gln Glu Glu Gln Ala 
385                 390                 395                 400 


Arg Pro Glu Tyr Glu Ala Arg Cys Xaa His Val Val Ile Asn Glu Ile 
                405                 410                 415     


Xaa Gln Glu Glu Glu Arg Ile Pro Phe Xaa Ala Trp Gly Lys Cys Ile 
            420                 425                 430         


Arg Ile Xaa Leu Cys Ala Ser Ala Val Phe Phe Trp Ile Leu Leu Ile 
        435                 440                 445             


Ile Ala Ser Val Ile Gly Ile Ile Val Tyr Arg Leu Ser Val Phe Ile 
    450                 455                 460                 


Val Phe Ser Ala Lys Leu Pro Lys Asn Ile Asn Gly Xaa Asp Pro Ile 
465                 470                 475                 480 


Gln Lys Tyr Leu Xaa Pro Gln Xaa Ala Xaa Ser Ile Xaa Ala Ser Ile 
                485                 490                 495     


Ile Ser Phe Ile Ile Ile Met Ile Leu Asn Xaa Ile Tyr Glu Lys Val 
            500                 505                 510         


Ala Ile Met Ile Xaa Asn Phe Glu Leu Pro Arg Xaa Gln Xaa Asp Tyr 
        515                 520                 525             


Glu Asn Ser Leu Xaa Met Lys Met Phe Leu Phe Gln Phe Val Asn Tyr 
    530                 535                 540                 


Tyr Ser Ser Cys Phe Tyr Ile Ala Phe Phe Lys Gly Lys Phe Val Gly 
545                 550                 555                 560 


Tyr Pro Gly Asp Pro Val Tyr Trp Leu Gly Lys Tyr Arg Asn Glu Glu 
                565                 570                 575     


Cys Asp Pro Gly Gly Cys Leu Leu Glu Leu Xaa Xaa Gln Leu Xaa Ile 
            580                 585                 590         


Ile Met Gly Gly Lys Ala Ile Trp Asn Asn Ile Gln Glu Val Leu Leu 
        595                 600                 605             


Pro Trp Ile Met Asn Leu Ile Gly Arg Phe His Arg Val Ser Gly Ser 
    610                 615                 620                 


Glu Lys Ile Xaa Pro Arg Trp Glu Gln Asp Tyr His Leu Gln Pro Met 
625                 630                 635                 640 


Gly Lys Leu Gly Leu Phe Tyr Glu Tyr Leu Glu Met Ile Ile Gln Phe 
                645                 650                 655     


Gly Phe Val Xaa Leu Phe Val Ala Ser Phe Pro Leu Ala Pro Leu Leu 
            660                 665                 670         


Ala Leu Val Asn Asn Ile Leu Glu Ile Arg Val Asp Ala Trp Lys Leu 
        675                 680                 685             


Xaa Xaa Gln Phe Arg Arg Leu Val Pro Glu Lys Ala Gln Asp Ile Gly 
    690                 695                 700                 


Ala Trp Gln Pro Ile Met Gln Gly Ile Ala Ile Leu Ala Val Val Xaa 
705                 710                 715                 720 


Asn Ala Met Ile Ile Ala Phe Xaa Ser Asp Met Ile Pro Arg Leu Val 
                725                 730                 735     


Tyr Tyr Trp Ser Phe Ser Val Pro Pro Tyr Gly Asp His Xaa Ser Tyr 
            740                 745                 750         


Xaa Met Glu Gly Tyr Ile Asn Asn Xaa Leu Ser Ile Phe Lys Val Ala 
        755                 760                 765             


Asp Phe Lys Asn Lys Ser Lys Gly Asn Pro Tyr Ser Asp Leu Gly Asn 
    770                 775                 780                 


His Xaa Xaa Cys Arg Tyr Arg Asp Phe Arg Tyr Pro Pro Gly His Pro 
785                 790                 795                 800 


Gln Glu Tyr Lys His Asn Ile Tyr Tyr Trp His Val Ile Ala Ala Lys 
                805                 810                 815     


Leu Ala Phe Ile Ile Val Met Glu His Val Ile Tyr Ser Val Lys Phe 
            820                 825                 830         


Phe Ile Ser Tyr Ala Ile Pro Asp Val Ser Lys Arg Xaa Lys Ser Lys 
        835                 840                 845             


Ile Gln Arg Glu Lys Tyr Leu Xaa Gln Lys Leu Leu His Glu Asn His 
    850                 855                 860                 


Leu Lys Asp Met Xaa Lys Asn Met Gly Val Ile Ala Glu Arg Met Ile 
865                 870                 875                 880 


Glu Ala Val Asp Asn Asn Leu Arg Pro Lys Ser Glu 
                885                 890         


<210> 2400
<211> 931
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<400> 2400
Met Lys Lys Met Ser Arg Asn Val Leu Leu Gln Met Glu Glu Glu Glu 
1               5                   10                  15      


Asp Asp Asp Asp Gly Asp Ile Gly Asp Val Pro Ala Ser Arg Arg Pro 
            20                  25                  30          


Phe Leu Xaa Pro His Xaa His Leu Pro Ser Ser Leu Val Leu Glu Asn 
        35                  40                  45              


Leu Gly Gln Xaa Ile Val Pro Asp Leu Gly Ser Leu Glu Ser Gln His 
    50                  55                  60                  


Asp Phe Arg Xaa Pro Glu Phe Glu Glu Phe Asn Gly Lys Pro Asp Ser 
65                  70                  75                  80  


Leu Phe Phe Asn Asp Gly Gln Arg Arg Ile Asp Phe Val Leu Val Tyr 
                85                  90                  95      


Glu Asp Glu Ser Arg Lys Glu Xaa Asn Lys Lys Gly Xaa Asn Glu Lys 
            100                 105                 110         


Gln Arg Arg Lys Arg Gln Ala Tyr Glu Ser Asn Leu Ile Cys His Gly 
        115                 120                 125             


Leu Gln Leu Glu Ala Xaa Arg Ser Val Leu Asp Asp Lys Leu Val Phe 
    130                 135                 140                 


Val Lys Val His Ala Pro Trp Glu Val Leu Cys Xaa Tyr Ala Glu Ile 
145                 150                 155                 160 


Met His Ile Lys Leu Pro Leu Lys Pro Asn Asp Leu Lys Asn Arg Ser 
                165                 170                 175     


Ser Ala Phe Gly Xaa Leu Asn Trp Phe Xaa Lys Val Leu Ser Val Asp 
            180                 185                 190         


Glu Ser Ile Ile Lys Pro Glu Gln Glu Phe Phe Xaa Ala Pro Phe Glu 
        195                 200                 205             


Lys Asn Arg Met Asn Asp Phe Tyr Ile Val Asp Arg Asp Ala Phe Phe 
    210                 215                 220                 


Asn Pro Ala Xaa Arg Ser Arg Ile Val Tyr Phe Ile Leu Ser Arg Val 
225                 230                 235                 240 


Lys Tyr Gln Val Ile Asn Asn Val Ser Lys Phe Gly Ile Asn Arg Leu 
                245                 250                 255     


Val Asn Ser Gly Ile Tyr Lys Ala Ala Phe Pro Leu His Asp Cys Lys 
            260                 265                 270         


Phe Arg Arg Gln Ser Glu Asp Pro Ser Cys Pro Asn Glu Arg Tyr Leu 
        275                 280                 285             


Leu Tyr Arg Glu Trp Ala His Pro Arg Ser Ile Tyr Lys Lys Gln Pro 
    290                 295                 300                 


Leu Asp Leu Ile Arg Lys Tyr Tyr Gly Glu Lys Ile Gly Ile Tyr Phe 
305                 310                 315                 320 


Ala Trp Leu Gly Tyr Tyr Xaa Gln Met Leu Leu Leu Ala Ala Val Val 
                325                 330                 335     


Gly Val Ala Cys Phe Leu Tyr Gly Tyr Leu Asn Gln Asp Asn Cys Xaa 
            340                 345                 350         


Trp Ser Lys Glu Val Cys His Pro Asp Ile Gly Gly Lys Ile Ile Met 
        355                 360                 365             


Cys Pro Gln Cys Asp Arg Leu Cys Pro Phe Trp Lys Leu Asn Ile Xaa 
    370                 375                 380                 


Cys Glu Ser Ser Lys Lys Leu Cys Ile Phe Asp Ser Phe Gly Xaa Leu 
385                 390                 395                 400 


Val Phe Ala Val Phe Met Gly Val Trp Val Xaa Leu Phe Leu Glu Phe 
                405                 410                 415     


Trp Lys Arg Arg Gln Ala Glu Leu Glu Tyr Glu Trp Asp Xaa Val Glu 
            420                 425                 430         


Leu Gln Gln Glu Glu Gln Ala Arg Pro Glu Tyr Glu Ala Arg Cys Xaa 
        435                 440                 445             


His Val Val Ile Asn Glu Ile Xaa Gln Glu Glu Glu Arg Ile Pro Phe 
    450                 455                 460                 


Xaa Ala Trp Gly Lys Cys Ile Arg Ile Xaa Leu Cys Ala Ser Ala Val 
465                 470                 475                 480 


Phe Phe Trp Ile Leu Leu Ile Ile Ala Ser Val Ile Gly Ile Ile Val 
                485                 490                 495     


Tyr Arg Leu Ser Val Phe Ile Val Phe Ser Ala Lys Leu Pro Lys Asn 
            500                 505                 510         


Ile Asn Gly Xaa Asp Pro Ile Gln Lys Tyr Leu Xaa Pro Gln Xaa Ala 
        515                 520                 525             


Xaa Ser Ile Xaa Ala Ser Ile Ile Ser Phe Ile Ile Ile Met Ile Leu 
    530                 535                 540                 


Asn Xaa Ile Tyr Glu Lys Val Ala Ile Met Ile Xaa Asn Phe Glu Leu 
545                 550                 555                 560 


Pro Arg Xaa Gln Xaa Asp Tyr Glu Asn Ser Leu Xaa Met Lys Met Phe 
                565                 570                 575     


Leu Phe Gln Phe Val Asn Tyr Tyr Ser Ser Cys Phe Tyr Ile Ala Phe 
            580                 585                 590         


Phe Lys Gly Lys Phe Val Gly Tyr Pro Gly Asp Pro Val Tyr Trp Leu 
        595                 600                 605             


Gly Lys Tyr Arg Asn Glu Glu Cys Asp Pro Gly Gly Cys Leu Leu Glu 
    610                 615                 620                 


Leu Xaa Xaa Gln Leu Xaa Ile Ile Met Gly Gly Lys Ala Ile Trp Asn 
625                 630                 635                 640 


Asn Ile Gln Glu Val Leu Leu Pro Trp Ile Met Asn Leu Ile Gly Arg 
                645                 650                 655     


Phe His Arg Val Ser Gly Ser Glu Lys Ile Xaa Pro Arg Trp Glu Gln 
            660                 665                 670         


Asp Tyr His Leu Gln Pro Met Gly Lys Leu Gly Leu Phe Tyr Glu Tyr 
        675                 680                 685             


Leu Glu Met Ile Ile Gln Phe Gly Phe Val Xaa Leu Phe Val Ala Ser 
    690                 695                 700                 


Phe Pro Leu Ala Pro Leu Leu Ala Leu Val Asn Asn Ile Leu Glu Ile 
705                 710                 715                 720 


Arg Val Asp Ala Trp Lys Leu Xaa Xaa Gln Phe Arg Arg Leu Val Pro 
                725                 730                 735     


Glu Lys Ala Gln Asp Ile Gly Ala Trp Gln Pro Ile Met Gln Gly Ile 
            740                 745                 750         


Ala Ile Leu Ala Val Val Xaa Asn Ala Met Ile Ile Ala Phe Xaa Ser 
        755                 760                 765             


Asp Met Ile Pro Arg Leu Val Tyr Tyr Trp Ser Phe Ser Val Pro Pro 
    770                 775                 780                 


Tyr Gly Asp His Xaa Ser Tyr Xaa Met Glu Gly Tyr Ile Asn Asn Xaa 
785                 790                 795                 800 


Leu Ser Ile Phe Lys Val Ala Asp Phe Lys Asn Lys Ser Lys Gly Asn 
                805                 810                 815     


Pro Tyr Ser Asp Leu Gly Asn His Xaa Xaa Cys Arg Tyr Arg Asp Phe 
            820                 825                 830         


Arg Tyr Pro Pro Gly His Pro Gln Glu Tyr Lys His Asn Ile Tyr Tyr 
        835                 840                 845             


Trp His Val Ile Ala Ala Lys Leu Ala Phe Ile Ile Val Met Glu His 
    850                 855                 860                 


Val Ile Tyr Ser Val Lys Phe Phe Ile Ser Tyr Ala Ile Pro Asp Val 
865                 870                 875                 880 


Ser Lys Arg Xaa Lys Ser Lys Ile Gln Arg Glu Lys Tyr Leu Xaa Gln 
                885                 890                 895     


Lys Leu Leu His Glu Asn His Leu Lys Asp Met Xaa Lys Asn Met Gly 
            900                 905                 910         


Val Ile Ala Glu Arg Met Ile Glu Ala Val Asp Asn Asn Leu Arg Pro 
        915                 920                 925             


Lys Ser Glu 
    930     


<210> 2401
<211> 45
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<400> 2401
Met Lys Lys Met Ser Arg Asn Val Leu Leu Gln Met Glu Glu Glu Glu 
1               5                   10                  15      


Asp Asp Asp Asp Gly Asp Ile Gly Leu Lys Cys Ser Ser Gly Val Ala 
            20                  25                  30          


Gln Ser Trp Leu Xaa Val Ala Leu Xaa Pro Arg Leu Asn 
        35                  40                  45  


<210> 2402
<211> 910
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<400> 2402
Met Lys Lys Met Ser Arg Asn Val Leu Leu Gln Met Glu Glu Glu Glu 
1               5                   10                  15      


Asp Asp Asp Asp Gly Asp Ile Val Leu Glu Asn Leu Gly Gln Xaa Ile 
            20                  25                  30          


Val Pro Asp Leu Gly Ser Leu Glu Ser Gln His Asp Phe Arg Xaa Pro 
        35                  40                  45              


Glu Phe Glu Glu Phe Asn Gly Lys Pro Asp Ser Leu Phe Phe Asn Asp 
    50                  55                  60                  


Gly Gln Arg Arg Ile Asp Phe Val Leu Val Tyr Glu Asp Glu Ser Arg 
65                  70                  75                  80  


Lys Glu Xaa Asn Lys Lys Gly Xaa Asn Glu Lys Gln Arg Arg Lys Arg 
                85                  90                  95      


Gln Ala Tyr Glu Ser Asn Leu Ile Cys His Gly Leu Gln Leu Glu Ala 
            100                 105                 110         


Xaa Arg Ser Val Leu Asp Asp Lys Leu Val Phe Val Lys Val His Ala 
        115                 120                 125             


Pro Trp Glu Val Leu Cys Xaa Tyr Ala Glu Ile Met His Ile Lys Leu 
    130                 135                 140                 


Pro Leu Lys Pro Asn Asp Leu Lys Asn Arg Ser Ser Ala Phe Gly Xaa 
145                 150                 155                 160 


Leu Asn Trp Phe Xaa Lys Val Leu Ser Val Asp Glu Ser Ile Ile Lys 
                165                 170                 175     


Pro Glu Gln Glu Phe Phe Xaa Ala Pro Phe Glu Lys Asn Arg Met Asn 
            180                 185                 190         


Asp Phe Tyr Ile Val Asp Arg Asp Ala Phe Phe Asn Pro Ala Xaa Arg 
        195                 200                 205             


Ser Arg Ile Val Tyr Phe Ile Leu Ser Arg Val Lys Tyr Gln Val Ile 
    210                 215                 220                 


Asn Asn Val Ser Lys Phe Gly Ile Asn Arg Leu Val Asn Ser Gly Ile 
225                 230                 235                 240 


Tyr Lys Ala Ala Phe Pro Leu His Asp Cys Lys Phe Arg Arg Gln Ser 
                245                 250                 255     


Glu Asp Pro Ser Cys Pro Asn Glu Arg Tyr Leu Leu Tyr Arg Glu Trp 
            260                 265                 270         


Ala His Pro Arg Ser Ile Tyr Lys Lys Gln Pro Leu Asp Leu Ile Arg 
        275                 280                 285             


Lys Tyr Tyr Gly Glu Lys Ile Gly Ile Tyr Phe Ala Trp Leu Gly Tyr 
    290                 295                 300                 


Tyr Xaa Gln Met Leu Leu Leu Ala Ala Val Val Gly Val Ala Cys Phe 
305                 310                 315                 320 


Leu Tyr Gly Tyr Leu Asn Gln Asp Asn Cys Xaa Trp Ser Lys Glu Val 
                325                 330                 335     


Cys His Pro Asp Ile Gly Gly Lys Ile Ile Met Cys Pro Gln Cys Asp 
            340                 345                 350         


Arg Leu Cys Pro Phe Trp Lys Leu Asn Ile Xaa Cys Glu Ser Ser Lys 
        355                 360                 365             


Lys Leu Cys Ile Phe Asp Ser Phe Gly Xaa Leu Val Phe Ala Val Phe 
    370                 375                 380                 


Met Gly Val Trp Val Xaa Leu Phe Leu Glu Phe Trp Lys Arg Arg Gln 
385                 390                 395                 400 


Ala Glu Leu Glu Tyr Glu Trp Asp Xaa Val Glu Leu Gln Gln Glu Glu 
                405                 410                 415     


Gln Ala Arg Pro Glu Tyr Glu Ala Arg Cys Xaa His Val Val Ile Asn 
            420                 425                 430         


Glu Ile Xaa Gln Glu Glu Glu Arg Ile Pro Phe Xaa Ala Trp Gly Lys 
        435                 440                 445             


Cys Ile Arg Ile Xaa Leu Cys Ala Ser Ala Val Phe Phe Trp Ile Leu 
    450                 455                 460                 


Leu Ile Ile Ala Ser Val Ile Gly Ile Ile Val Tyr Arg Leu Ser Val 
465                 470                 475                 480 


Phe Ile Val Phe Ser Ala Lys Leu Pro Lys Asn Ile Asn Gly Xaa Asp 
                485                 490                 495     


Pro Ile Gln Lys Tyr Leu Xaa Pro Gln Xaa Ala Xaa Ser Ile Xaa Ala 
            500                 505                 510         


Ser Ile Ile Ser Phe Ile Ile Ile Met Ile Leu Asn Xaa Ile Tyr Glu 
        515                 520                 525             


Lys Val Ala Ile Met Ile Xaa Asn Phe Glu Leu Pro Arg Xaa Gln Xaa 
    530                 535                 540                 


Asp Tyr Glu Asn Ser Leu Xaa Met Lys Met Phe Leu Phe Gln Phe Val 
545                 550                 555                 560 


Asn Tyr Tyr Ser Ser Cys Phe Tyr Ile Ala Phe Phe Lys Gly Lys Phe 
                565                 570                 575     


Val Gly Tyr Pro Gly Asp Pro Val Tyr Trp Leu Gly Lys Tyr Arg Asn 
            580                 585                 590         


Glu Glu Cys Asp Pro Gly Gly Cys Leu Leu Glu Leu Xaa Xaa Gln Leu 
        595                 600                 605             


Xaa Ile Ile Met Gly Gly Lys Ala Ile Trp Asn Asn Ile Gln Glu Val 
    610                 615                 620                 


Leu Leu Pro Trp Ile Met Asn Leu Ile Gly Arg Phe His Arg Val Ser 
625                 630                 635                 640 


Gly Ser Glu Lys Ile Xaa Pro Arg Trp Glu Gln Asp Tyr His Leu Gln 
                645                 650                 655     


Pro Met Gly Lys Leu Gly Leu Phe Tyr Glu Tyr Leu Glu Met Ile Ile 
            660                 665                 670         


Gln Phe Gly Phe Val Xaa Leu Phe Val Ala Ser Phe Pro Leu Ala Pro 
        675                 680                 685             


Leu Leu Ala Leu Val Asn Asn Ile Leu Glu Ile Arg Val Asp Ala Trp 
    690                 695                 700                 


Lys Leu Xaa Xaa Gln Phe Arg Arg Leu Val Pro Glu Lys Ala Gln Asp 
705                 710                 715                 720 


Ile Gly Ala Trp Gln Pro Ile Met Gln Gly Ile Ala Ile Leu Ala Val 
                725                 730                 735     


Val Xaa Asn Ala Met Ile Ile Ala Phe Xaa Ser Asp Met Ile Pro Arg 
            740                 745                 750         


Leu Val Tyr Tyr Trp Ser Phe Ser Val Pro Pro Tyr Gly Asp His Xaa 
        755                 760                 765             


Ser Tyr Xaa Met Glu Gly Tyr Ile Asn Asn Xaa Leu Ser Ile Phe Lys 
    770                 775                 780                 


Val Ala Asp Phe Lys Asn Lys Ser Lys Gly Asn Pro Tyr Ser Asp Leu 
785                 790                 795                 800 


Gly Asn His Xaa Xaa Cys Arg Tyr Arg Asp Phe Arg Tyr Pro Pro Gly 
                805                 810                 815     


His Pro Gln Glu Tyr Lys His Asn Ile Tyr Tyr Trp His Val Ile Ala 
            820                 825                 830         


Ala Lys Leu Ala Phe Ile Ile Val Met Glu His Val Ile Tyr Ser Val 
        835                 840                 845             


Lys Phe Phe Ile Ser Tyr Ala Ile Pro Asp Val Ser Lys Arg Xaa Lys 
    850                 855                 860                 


Ser Lys Ile Gln Arg Glu Lys Tyr Leu Xaa Gln Lys Leu Leu His Glu 
865                 870                 875                 880 


Asn His Leu Lys Asp Met Xaa Lys Asn Met Gly Val Ile Ala Glu Arg 
                885                 890                 895     


Met Ile Glu Ala Val Asp Asn Asn Leu Arg Pro Lys Ser Glu 
            900                 905                 910 


<210> 2403
<211> 929
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<400> 2403
Met Lys Lys Met Ser Arg Asn Val Leu Leu Gln Met Glu Glu Glu Glu 
1               5                   10                  15      


Asp Asp Asp Asp Gly Asp Ile Val Leu Glu Asn Leu Gly Gln Xaa Ile 
            20                  25                  30          


Val Pro Asp Leu Gly Ser Leu Glu Ser Gln His Asp Phe Arg Xaa Pro 
        35                  40                  45              


Glu Phe Glu Glu Phe Asn Gly Lys Pro Asp Ser Leu Phe Phe Asn Asp 
    50                  55                  60                  


Gly Gln Arg Arg Ile Asp Phe Val Leu Val Tyr Glu Asp Glu Ser Arg 
65                  70                  75                  80  


Lys Glu Xaa Asn Lys Lys Gly Xaa Asn Glu Lys Gln Arg Arg Lys Arg 
                85                  90                  95      


Gln Ala Tyr Glu Ser Asn Leu Ile Cys His Gly Leu Gln Leu Glu Ala 
            100                 105                 110         


Xaa Arg Ser Val Leu Asp Asp Lys Leu Val Phe Val Lys Val His Ala 
        115                 120                 125             


Pro Trp Glu Val Leu Cys Xaa Tyr Ala Glu Ile Met His Ile Lys Leu 
    130                 135                 140                 


Pro Leu Lys Pro Asn Asp Leu Lys Asn Arg Ser Ser Ala Phe Gly Xaa 
145                 150                 155                 160 


Leu Asn Trp Phe Xaa Lys Val Leu Ser Val Asp Glu Ser Ile Ile Lys 
                165                 170                 175     


Pro Glu Gln Glu Phe Phe Xaa Ala Pro Phe Glu Lys Asn Arg Met Asn 
            180                 185                 190         


Asp Phe Tyr Ile Val Asp Arg Asp Ala Phe Phe Asn Pro Ala Xaa Arg 
        195                 200                 205             


Ser Arg Ile Val Tyr Phe Ile Leu Ser Arg Val Lys Tyr Gln Val Ile 
    210                 215                 220                 


Asn Asn Val Ser Lys Phe Gly Ile Asn Arg Leu Val Asn Ser Gly Ile 
225                 230                 235                 240 


Tyr Lys Ala Ala Phe Pro Leu His Asp Cys Lys Phe Arg Arg Gln Ser 
                245                 250                 255     


Glu Asp Pro Ser Cys Pro Asn Glu Arg Tyr Leu Leu Tyr Arg Glu Trp 
            260                 265                 270         


Ala His Pro Arg Ser Ile Tyr Lys Lys Gln Pro Leu Asp Leu Ile Arg 
        275                 280                 285             


Lys Tyr Tyr Gly Glu Lys Ile Gly Ile Tyr Phe Ala Trp Leu Gly Tyr 
    290                 295                 300                 


Tyr Xaa Gln Met Leu Leu Leu Ala Ala Val Val Gly Val Ala Cys Phe 
305                 310                 315                 320 


Leu Tyr Gly Tyr Leu Asn Gln Asp Asn Cys Xaa Trp Ser Lys Glu Val 
                325                 330                 335     


Cys His Pro Asp Ile Gly Gly Lys Ile Ile Met Cys Pro Gln Cys Asp 
            340                 345                 350         


Arg Leu Cys Pro Phe Trp Lys Leu Asn Ile Xaa Cys Glu Ser Ser Lys 
        355                 360                 365             


Lys Leu Cys Ile Phe Asp Ser Phe Gly Xaa Leu Val Phe Ala Val Phe 
    370                 375                 380                 


Met Gly Val Trp Val Xaa Leu Phe Leu Glu Phe Trp Lys Arg Arg Gln 
385                 390                 395                 400 


Ala Glu Leu Glu Tyr Glu Trp Asp Xaa Val Glu Leu Gln Gln Glu Glu 
                405                 410                 415     


Gln Ala Arg Pro Glu Tyr Glu Ala Arg Cys Xaa His Val Val Ile Asn 
            420                 425                 430         


Glu Ile Xaa Gln Glu Glu Glu Arg Ile Pro Phe Xaa Ala Trp Gly Lys 
        435                 440                 445             


Cys Ile Arg Ile Xaa Leu Cys Ala Ser Ala Val Phe Phe Trp Ile Leu 
    450                 455                 460                 


Leu Ile Ile Ala Ser Val Ile Gly Ile Ile Val Tyr Arg Leu Ser Val 
465                 470                 475                 480 


Phe Ile Val Phe Ser Ala Lys Leu Pro Lys Asn Ile Asn Gly Xaa Asp 
                485                 490                 495     


Pro Ile Gln Lys Tyr Leu Xaa Pro Gln Xaa Ala Xaa Ser Ile Xaa Ala 
            500                 505                 510         


Ser Ile Ile Ser Phe Ile Ile Ile Met Ile Leu Asn Xaa Ile Tyr Glu 
        515                 520                 525             


Lys Val Ala Ile Met Ile Xaa Asn Phe Glu Leu Pro Arg Xaa Gln Xaa 
    530                 535                 540                 


Asp Tyr Glu Asn Ser Leu Xaa Met Lys Met Phe Leu Phe Gln Phe Val 
545                 550                 555                 560 


Asn Tyr Tyr Ser Ser Cys Phe Tyr Ile Ala Phe Phe Lys Gly Lys Phe 
                565                 570                 575     


Val Gly Tyr Pro Gly Asp Pro Val Tyr Trp Leu Gly Lys Tyr Arg Asn 
            580                 585                 590         


Glu Glu Cys Asp Pro Gly Gly Cys Leu Leu Glu Leu Xaa Xaa Gln Leu 
        595                 600                 605             


Xaa Ile Ile Met Gly Gly Lys Ala Ile Trp Asn Asn Ile Gln Glu Val 
    610                 615                 620                 


Leu Leu Pro Trp Ile Met Asn Leu Ile Gly Arg Phe His Arg Val Ser 
625                 630                 635                 640 


Gly Ser Glu Lys Ile Xaa Pro Arg Trp Glu Gln Asp Tyr His Leu Gln 
                645                 650                 655     


Pro Met Gly Lys Leu Gly Leu Phe Tyr Glu Tyr Leu Glu Met Ile Ile 
            660                 665                 670         


Gln Phe Gly Phe Val Xaa Leu Phe Val Ala Ser Phe Pro Leu Ala Pro 
        675                 680                 685             


Leu Leu Ala Leu Val Asn Asn Ile Leu Glu Ile Arg Val Asp Ala Trp 
    690                 695                 700                 


Lys Leu Xaa Xaa Gln Phe Arg Arg Leu Val Pro Glu Lys Ala Gln Asp 
705                 710                 715                 720 


Ile Gly Ala Trp Gln Pro Ile Met Gln Gly Ile Ala Ile Leu Ala Val 
                725                 730                 735     


Val Xaa Asn Ala Met Ile Ile Ala Phe Xaa Ser Asp Met Ile Pro Arg 
            740                 745                 750         


Leu Val Tyr Tyr Trp Ser Phe Ser Val Pro Pro Tyr Gly Asp His Xaa 
        755                 760                 765             


Ser Tyr Xaa Met Glu Gly Tyr Ile Asn Asn Xaa Leu Ser Ile Phe Lys 
    770                 775                 780                 


Val Ala Asp Phe Lys Asn Lys Ser Lys Gly Asn Pro Tyr Ser Asp Leu 
785                 790                 795                 800 


Gly Asn His Xaa Xaa Cys Arg Tyr Arg Asp Phe Arg Tyr Pro Pro Gly 
                805                 810                 815     


His Pro Gln Glu Tyr Lys His Asn Ile Tyr Tyr Trp His Val Ile Ala 
            820                 825                 830         


Ala Lys Leu Ala Phe Ile Ile Val Met Glu Tyr Leu Ala Leu Leu Pro 
        835                 840                 845             


Arg Leu Gly His Ser Gly Met Ile Leu Ala His Cys Asn Leu Arg Leu 
    850                 855                 860                 


Pro Val Asp Cys Cys Met Cys Tyr Arg Phe Val Asp Glu Ile Arg Leu 
865                 870                 875                 880 


Leu Glu Gln Leu Xaa Ser Asp Phe Ile Asp Ser Leu Tyr Tyr Ile Phe 
                885                 890                 895     


Ser Ile Ser Ile Ile Ser Ile Phe Phe Ser Val Xaa Phe Phe Phe Leu 
            900                 905                 910         


Leu Leu Ser Leu Gly Pro Xaa Pro Cys Phe Ser Val Ser Asn Phe Leu 
        915                 920                 925             


Ser 
    


<210> 2404
<211> 680
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<400> 2404
Met Val Pro Gly Val Pro Gly Ala Val Leu Xaa Leu Cys Leu Trp Leu 
1               5                   10                  15      


Ala Ala Ser Ser Gly Cys Leu Ala Ala Gly Pro Gly Ala Ala Ala Ala 
            20                  25                  30          


Arg Arg Leu Asp Glu Ser Leu Ser Ala Gly Ser Val Gln Arg Ala Arg 
        35                  40                  45              


Cys Ala Ser Arg Cys Leu Ser Leu Gln Ile Xaa Arg Ile Ser Ala Phe 
    50                  55                  60                  


Phe Gln His Phe Gln Asn Asn Gly Ser Leu Val Trp Cys Gln Asn His 
65                  70                  75                  80  


Lys Gln Cys Ser Lys Cys Leu Glu Pro Cys Lys Glu Ser Gly Asp Leu 
                85                  90                  95      


Arg Lys His Gln Cys Gln Ser Phe Cys Glu Pro Leu Phe Pro Lys Lys 
            100                 105                 110         


Ser Tyr Glu Cys Leu Xaa Ser Cys Glu Phe Leu Lys Tyr Ile Leu Leu 
        115                 120                 125             


Val Lys Gln Gly Asp Cys Pro Ala Pro Glu Lys Ala Ser Gly Phe Ala 
    130                 135                 140                 


Ala Ala Cys Val Glu Ser Cys Glu Val Asp Asn Glu Cys Ser Gly Val 
145                 150                 155                 160 


Lys Lys Cys Cys Ser Asn Gly Cys Gly His Xaa Cys Gln Val Pro Lys 
                165                 170                 175     


Xaa Leu Tyr Lys Gly Val Pro Leu Lys Pro Arg Lys Glu Leu Arg Phe 
            180                 185                 190         


Xaa Glu Leu Gln Ser Gly Gln Leu Glu Val Lys Trp Ser Ser Lys Phe 
        195                 200                 205             


Asn Ile Ser Ile Glu Pro Val Ile Tyr Val Val Gln Arg Arg Trp Asn 
    210                 215                 220                 


Tyr Gly Ile His Pro Ser Glu Asp Asp Ala Xaa His Trp Gln Xaa Val 
225                 230                 235                 240 


Ala Gln Xaa Xaa Asp Glu Arg Val Gln Leu Xaa Asp Ile Arg Pro Ser 
                245                 250                 255     


Arg Trp Tyr Gln Phe Arg Val Ala Ala Val Asn Val His Gly Xaa Arg 
            260                 265                 270         


Gly Phe Xaa Ala Pro Ser Lys His Phe Arg Ser Ser Lys Asp Pro Ser 
        275                 280                 285             


Ala Pro Pro Ala Pro Ala Asn Leu Arg Leu Ala Asn Ser Xaa Val Asn 
    290                 295                 300                 


Ser Asp Gly Ser Val Xaa Val Xaa Ile Val Trp Asp Leu Pro Glu Glu 
305                 310                 315                 320 


Pro Asp Ile Pro Val His His Tyr Lys Val Phe Trp Ser Trp Met Val 
                325                 330                 335     


Ser Ser Lys Ser Leu Val Pro Xaa Lys Lys Lys Arg Arg Lys Xaa Xaa 
            340                 345                 350         


Asp Gly Phe Gln Asn Ser Val Ile Leu Glu Lys Leu Gln Pro Asp Cys 
        355                 360                 365             


Asp Tyr Val Val Glu Leu Gln Ala Ile Xaa Tyr Trp Gly Gln Xaa Arg 
    370                 375                 380                 


Leu Lys Ser Ala Lys Val Ser Leu His Phe Xaa Ser Xaa His Ala Xaa 
385                 390                 395                 400 


Asn Asn Lys Glu Gln Leu Val Lys Xaa Arg Lys Gly Gly Ile Gln Xaa 
                405                 410                 415     


Gln Leu Pro Phe Gln Arg Arg Arg Pro Xaa Arg Pro Leu Glu Val Gly 
            420                 425                 430         


Ala Pro Phe Tyr Gln Asp Gly Gln Leu Gln Val Lys Val Tyr Trp Lys 
        435                 440                 445             


Lys Xaa Glu Asp Pro Xaa Val Asn Arg Tyr His Val Arg Trp Phe Pro 
    450                 455                 460                 


Glu Ala Cys Ala His Asn Arg Xaa Xaa Gly Ser Glu Ala Ser Ser Gly 
465                 470                 475                 480 


Met Xaa His Glu Asn Tyr Ile Ile Leu Gln Asp Leu Ser Phe Ser Cys 
                485                 490                 495     


Lys Tyr Lys Val Xaa Val Gln Pro Ile Arg Pro Lys Ser His Ser Lys 
            500                 505                 510         


Ala Glu Ala Val Phe Phe Xaa Xaa Pro Pro Cys Ser Ala Leu Lys Gly 
        515                 520                 525             


Lys Ser His Lys Pro Val Gly Cys Leu Gly Glu Ala Gly His Val Leu 
    530                 535                 540                 


Ser Lys Val Leu Ala Lys Pro Glu Asn Leu Ser Ala Ser Phe Ile Val 
545                 550                 555                 560 


Gln Asp Val Asn Ile Xaa Gly His Phe Ser Trp Lys Met Ala Lys Ala 
                565                 570                 575     


Asn Leu Tyr Gln Pro Met Xaa Gly Phe Gln Val Xaa Trp Ala Glu Val 
            580                 585                 590         


Xaa Xaa Glu Ser Arg Gln Asn Ser Leu Pro Asn Ser Ile Ile Ser Gln 
        595                 600                 605             


Ser Gln Ile Leu Pro Ser Asp His Tyr Val Leu Xaa Val Pro Asn Leu 
    610                 615                 620                 


Arg Pro Ser Xaa Leu Tyr Arg Leu Glu Val Gln Val Leu Xaa Pro Gly 
625                 630                 635                 640 


Gly Glu Gly Pro Ala Xaa Ile Lys Xaa Phe Arg Xaa Pro Glu Leu Pro 
                645                 650                 655     


Pro Ser Ser Ala His Arg Ser His Leu Lys His Arg His Pro His His 
            660                 665                 670         


Tyr Lys Pro Ser Pro Glu Arg Tyr 
        675                 680 


<210> 2405
<211> 249
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<400> 2405
Met Glu Met Gly Arg Arg Ile His Leu Glu Leu Arg Asn Arg Xaa Pro 
1               5                   10                  15      


Ser Asp Val Lys Glu Leu Val Leu Asp Asn Ser Arg Ser Asn Glu Gly 
            20                  25                  30          


Lys Leu Glu Gly Leu Xaa Asp Glu Phe Glu Glu Leu Glu Phe Leu Ser 
        35                  40                  45              


Xaa Ile Asn Val Gly Leu Xaa Ser Ile Ala Asn Leu Pro Lys Leu Asn 
    50                  55                  60                  


Lys Leu Lys Lys Leu Glu Leu Ser Asp Asn Arg Val Ser Gly Gly Leu 
65                  70                  75                  80  


Glu Val Leu Ala Glu Lys Cys Pro Asn Leu Xaa His Leu Asn Leu Ser 
                85                  90                  95      


Gly Asn Lys Ile Lys Asp Leu Ser Xaa Ile Glu Pro Leu Lys Lys Leu 
            100                 105                 110         


Glu Asn Leu Lys Ser Leu Asp Leu Phe Asn Cys Glu Val Xaa Asn Leu 
        115                 120                 125             


Asn Asp Tyr Arg Glu Asn Val Phe Lys Leu Leu Pro Gln Leu Xaa Tyr 
    130                 135                 140                 


Leu Asp Gly Tyr Asp Arg Asp Asp Lys Glu Ala Pro Asp Ser Asp Ala 
145                 150                 155                 160 


Glu Gly Tyr Val Glu Gly Leu Asp Asp Glu Glu Glu Asp Glu Asp Glu 
                165                 170                 175     


Glu Glu Tyr Asp Glu Asp Ala Gln Val Val Glu Asp Glu Glu Asp Glu 
            180                 185                 190         


Asp Glu Glu Glu Glu Gly Glu Glu Glu Asp Val Ser Gly Glu Glu Glu 
        195                 200                 205             


Glu Asp Glu Glu Gly Tyr Asn Asp Gly Glu Val Asp Asp Glu Glu Asp 
    210                 215                 220                 


Glu Glu Glu Leu Gly Glu Glu Glu Arg Gly Gln Lys Arg Lys Arg Glu 
225                 230                 235                 240 


Pro Glu Asp Glu Gly Glu Asp Asp Asp 
                245                 


<210> 2406
<211> 177
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<400> 2406
Met Glu Met Gly Arg Arg Ile His Leu Glu Leu Arg Asn Arg Xaa Pro 
1               5                   10                  15      


Ser Asp Val Lys Glu Leu Val Leu Asp Asn Ser Arg Ser Asn Glu Gly 
            20                  25                  30          


Lys Leu Glu Gly Leu Xaa Asp Glu Phe Glu Glu Leu Glu Phe Leu Ser 
        35                  40                  45              


Xaa Ile Asn Val Gly Leu Xaa Ser Ile Ala Asn Leu Pro Lys Leu Asn 
    50                  55                  60                  


Lys Leu Lys Lys Leu Glu Leu Ser Asp Asn Arg Val Ser Gly Gly Leu 
65                  70                  75                  80  


Glu Val Leu Ala Glu Lys Cys Pro Asn Leu Xaa His Leu Asn Leu Ser 
                85                  90                  95      


Gly Asn Lys Ile Lys Asp Leu Ser Xaa Ile Glu Pro Leu Lys Lys Leu 
            100                 105                 110         


Glu Asn Leu Lys Ser Leu Asp Leu Phe Asn Cys Glu Val Xaa Asn Leu 
        115                 120                 125             


Asn Asp Tyr Arg Glu Asn Val Phe Lys Leu Leu Pro Gln Leu Xaa Tyr 
    130                 135                 140                 


Leu Asp Gly Tyr Asp Arg Asp Asp Lys Glu Ala Pro Asp Ser Asp Ala 
145                 150                 155                 160 


Glu Gly Tyr Val Glu Gly Leu Asp Asp Glu Glu Glu Asp Glu Asp Gly 
                165                 170                 175     


Gly 
    


<210> 2407
<211> 79
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<400> 2407
Met Glu Met Gly Arg Arg Ile His Leu Glu Leu Arg Asn Arg Xaa Pro 
1               5                   10                  15      


Ser Asp Val Lys Glu Leu Val Leu Asp Asn Ser Arg Ser Asn Glu Gly 
            20                  25                  30          


Lys Leu Glu Gly Leu Xaa Asp Glu Phe Glu Glu Leu Glu Phe Leu Ser 
        35                  40                  45              


Xaa Ile Asn Val Gly Leu Xaa Ser Ile Ala Asn Leu Pro Lys Leu Asn 
    50                  55                  60                  


Lys Leu Lys Lys Tyr Trp Gln Lys Ser Val Arg Xaa Ser Arg Ile 
65                  70                  75                  


<210> 2408
<211> 333
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(328)
<223> Selenocysteine

<400> 2408
Met Ala Xaa Ala Glu Arg Arg Ala Leu Gly Ile Gly Phe Gln Trp Leu 
1               5                   10                  15      


Ser Leu Ala Xaa Leu Val Leu Ile Cys Ala Gly Gln Gly Gly Arg Arg 
            20                  25                  30          


Glu Asp Gly Gly Pro Ala Cys Tyr Gly Gly Phe Asp Leu Tyr Phe Ile 
        35                  40                  45              


Leu Asp Lys Ser Gly Ser Val Leu His His Trp Asn Glu Ile Tyr Tyr 
    50                  55                  60                  


Phe Val Glu Gln Leu Ala His Lys Phe Ile Ser Pro Gln Leu Arg Met 
65                  70                  75                  80  


Ser Phe Ile Val Phe Ser Xaa Arg Gly Xaa Xaa Leu Met Lys Leu Xaa 
                85                  90                  95      


Glu Asp Arg Glu Gln Ile Arg Gln Gly Leu Glu Glu Leu Gln Lys Val 
            100                 105                 110         


Leu Pro Gly Gly Asp Xaa Tyr Met His Glu Gly Phe Glu Arg Ala Ser 
        115                 120                 125             


Glu Gln Ile Tyr Tyr Glu Asn Arg Gln Gly Tyr Arg Xaa Ala Ser Val 
    130                 135                 140                 


Ile Ile Ala Leu Xaa Asp Gly Glu Leu His Glu Asp Leu Phe Phe Tyr 
145                 150                 155                 160 


Ser Glu Arg Glu Ala Asn Arg Ser Arg Asp Leu Gly Ala Ile Val Tyr 
                165                 170                 175     


Cys Val Gly Val Lys Asp Phe Asn Glu Xaa Gln Leu Ala Arg Ile Ala 
            180                 185                 190         


Asp Ser Lys Asp His Val Phe Pro Val Asn Asp Gly Phe Gln Ala Leu 
        195                 200                 205             


Gln Gly Ile Ile His Ser Ile Leu Lys Lys Ser Cys Ile Glu Ile Leu 
    210                 215                 220                 


Ala Ala Glu Pro Ser Xaa Ile Cys Ala Gly Glu Ser Phe Gln Val Val 
225                 230                 235                 240 


Val Arg Gly Asn Gly Phe Arg His Ala Arg Asn Val Asp Arg Val Leu 
                245                 250                 255     


Cys Ser Phe Lys Ile Asn Asp Ser Val Xaa Leu Asn Glu Lys Pro Phe 
            260                 265                 270         


Ser Val Glu Asp Xaa Tyr Leu Leu Cys Pro Ala Pro Ile Leu Lys Glu 
        275                 280                 285             


Val Gly Met Lys Ala Ala Leu Gln Val Ser Met Asn Asp Gly Leu Ser 
    290                 295                 300                 


Phe Ile Ser Ser Ser Val Ile Ile Xaa Xaa Xaa His Cys Ser Leu His 
305                 310                 315                 320 


Lys Ile Ala Ser Gly Pro Xaa Xaa Ala Ala Cys Met Glu 
                325                 330             


<210> 2409
<211> 368
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<400> 2409
Met Ala Xaa Ala Glu Arg Arg Ala Leu Gly Ile Gly Phe Gln Trp Leu 
1               5                   10                  15      


Ser Leu Ala Xaa Leu Val Leu Ile Cys Ala Gly Gln Gly Gly Arg Arg 
            20                  25                  30          


Glu Asp Gly Gly Pro Ala Cys Tyr Gly Gly Phe Asp Leu Tyr Phe Ile 
        35                  40                  45              


Leu Asp Lys Ser Gly Ser Val Leu His His Trp Asn Glu Ile Tyr Tyr 
    50                  55                  60                  


Phe Val Glu Gln Leu Ala His Lys Phe Ile Ser Pro Gln Leu Arg Met 
65                  70                  75                  80  


Ser Phe Ile Val Phe Ser Xaa Arg Gly Xaa Xaa Leu Met Lys Leu Xaa 
                85                  90                  95      


Glu Asp Arg Glu Gln Ile Arg Gln Gly Leu Glu Glu Leu Gln Lys Val 
            100                 105                 110         


Leu Pro Gly Gly Asp Xaa Tyr Met His Glu Gly Phe Glu Arg Ala Ser 
        115                 120                 125             


Glu Gln Ile Tyr Tyr Glu Asn Arg Gln Gly Tyr Arg Xaa Ala Ser Val 
    130                 135                 140                 


Ile Ile Ala Leu Xaa Asp Gly Glu Leu His Glu Asp Leu Phe Phe Tyr 
145                 150                 155                 160 


Ser Glu Arg Glu Ala Asn Arg Ser Arg Asp Leu Gly Ala Ile Val Tyr 
                165                 170                 175     


Cys Val Gly Val Lys Asp Phe Asn Glu Xaa Gln Leu Ala Arg Ile Ala 
            180                 185                 190         


Asp Ser Lys Asp His Val Phe Pro Val Asn Asp Gly Phe Gln Ala Leu 
        195                 200                 205             


Gln Gly Ile Ile His Ser Ile Leu Lys Lys Ser Cys Ile Glu Ile Leu 
    210                 215                 220                 


Ala Ala Glu Pro Ser Xaa Ile Cys Ala Gly Glu Ser Phe Gln Val Val 
225                 230                 235                 240 


Val Arg Gly Asn Gly Phe Arg His Ala Arg Asn Val Asp Arg Val Leu 
                245                 250                 255     


Cys Ser Phe Lys Ile Asn Asp Ser Val Xaa Leu Asn Glu Lys Pro Phe 
            260                 265                 270         


Ser Val Glu Asp Xaa Tyr Leu Leu Cys Pro Ala Pro Ile Leu Lys Glu 
        275                 280                 285             


Val Gly Met Lys Ala Ala Leu Gln Val Ser Met Asn Asp Gly Leu Ser 
    290                 295                 300                 


Phe Ile Ser Ser Ser Val Ile Ile Xaa Xaa Xaa His Cys Ser Asp Gly 
305                 310                 315                 320 


Ser Ile Leu Ala Ile Ala Leu Leu Ile Leu Phe Leu Leu Leu Ala Leu 
                325                 330                 335     


Ala Leu Leu Trp Trp Phe Trp Pro Leu Cys Cys Xaa Val Ile Ile Lys 
            340                 345                 350         


Glu Val Pro Pro Pro Pro Ala Glu Glu Ser Glu Glu Asn Lys Ile Lys 
        355                 360                 365             


<210> 2410
<211> 564
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<400> 2410
Met Ala Xaa Ala Glu Arg Arg Ala Leu Gly Ile Gly Phe Gln Trp Leu 
1               5                   10                  15      


Ser Leu Ala Xaa Leu Val Leu Ile Cys Ala Gly Gln Gly Gly Arg Arg 
            20                  25                  30          


Glu Asp Gly Gly Pro Ala Cys Tyr Gly Gly Phe Asp Leu Tyr Phe Ile 
        35                  40                  45              


Leu Asp Lys Ser Gly Ser Val Leu His His Trp Asn Glu Ile Tyr Tyr 
    50                  55                  60                  


Phe Val Glu Gln Leu Ala His Lys Phe Ile Ser Pro Gln Leu Arg Met 
65                  70                  75                  80  


Ser Phe Ile Val Phe Ser Xaa Arg Gly Xaa Xaa Leu Met Lys Leu Xaa 
                85                  90                  95      


Glu Asp Arg Glu Gln Ile Arg Gln Gly Leu Glu Glu Leu Gln Lys Val 
            100                 105                 110         


Leu Pro Gly Gly Asp Xaa Tyr Met His Glu Gly Phe Glu Arg Ala Ser 
        115                 120                 125             


Glu Gln Ile Tyr Tyr Glu Asn Arg Gln Gly Tyr Arg Xaa Ala Ser Val 
    130                 135                 140                 


Ile Ile Ala Leu Xaa Asp Gly Glu Leu His Glu Asp Leu Phe Phe Tyr 
145                 150                 155                 160 


Ser Glu Arg Glu Ala Asn Arg Ser Arg Asp Leu Gly Ala Ile Val Tyr 
                165                 170                 175     


Cys Val Gly Val Lys Asp Phe Asn Glu Xaa Gln Leu Ala Arg Ile Ala 
            180                 185                 190         


Asp Ser Lys Asp His Val Phe Pro Val Asn Asp Gly Phe Gln Ala Leu 
        195                 200                 205             


Gln Gly Ile Ile His Ser Ile Leu Lys Lys Ser Cys Ile Glu Ile Leu 
    210                 215                 220                 


Ala Ala Glu Pro Ser Xaa Ile Cys Ala Gly Glu Ser Phe Gln Val Val 
225                 230                 235                 240 


Val Arg Gly Asn Gly Phe Arg His Ala Arg Asn Val Asp Arg Val Leu 
                245                 250                 255     


Cys Ser Phe Lys Ile Asn Asp Ser Val Xaa Leu Asn Glu Lys Pro Phe 
            260                 265                 270         


Ser Val Glu Asp Xaa Tyr Leu Leu Cys Pro Ala Pro Ile Leu Lys Glu 
        275                 280                 285             


Val Gly Met Lys Ala Ala Leu Gln Val Ser Met Asn Asp Gly Leu Ser 
    290                 295                 300                 


Phe Ile Ser Ser Ser Val Ile Ile Xaa Xaa Xaa His Cys Ser Asp Gly 
305                 310                 315                 320 


Ser Ile Leu Ala Ile Ala Leu Leu Ile Leu Phe Leu Leu Leu Ala Leu 
                325                 330                 335     


Ala Leu Leu Trp Trp Phe Trp Pro Leu Cys Cys Xaa Val Ile Ile Lys 
            340                 345                 350         


Glu Val Pro Pro Pro Pro Ala Glu Glu Ser Glu Glu Glu Asp Asp Asp 
        355                 360                 365             


Gly Leu Pro Lys Lys Lys Trp Pro Xaa Val Asp Ala Ser Tyr Tyr Gly 
    370                 375                 380                 


Gly Arg Gly Val Gly Gly Ile Lys Arg Met Glu Val Arg Trp Gly Glu 
385                 390                 395                 400 


Lys Gly Ser Xaa Glu Glu Gly Ala Lys Leu Glu Lys Ala Lys Asn Ala 
                405                 410                 415     


Arg Val Lys Met Pro Glu Gln Glu Tyr Glu Phe Pro Glu Pro Arg Asn 
            420                 425                 430         


Leu Asn Asn Asn Met Arg Arg Pro Ser Ser Pro Arg Lys Trp Tyr Ser 
        435                 440                 445             


Pro Ile Lys Gly Lys Leu Asp Ala Leu Trp Val Leu Leu Arg Lys Gly 
    450                 455                 460                 


Tyr Asp Arg Val Ser Val Met Arg Pro Gln Pro Gly Asp Xaa Gly Arg 
465                 470                 475                 480 


Cys Ile Asn Phe Xaa Arg Val Lys Asn Asn Gln Pro Ala Lys Tyr Pro 
                485                 490                 495     


Leu Asn Asn Ala Tyr His Xaa Ser Ser Pro Pro Pro Ala Pro Ile Tyr 
            500                 505                 510         


Xaa Pro Pro Pro Pro Ala Pro His Cys Pro Pro Pro Pro Pro Ser Ala 
        515                 520                 525             


Pro Xaa Pro Pro Ile Pro Ser Pro Pro Ser Xaa Leu Pro Pro Pro Pro 
    530                 535                 540                 


Gln Ala Pro Pro Pro Asn Arg Ala Pro Pro Pro Ser Arg Pro Pro Pro 
545                 550                 555                 560 


Arg Pro Ser Val 
                


<210> 2411
<211> 179
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<400> 2411
Xaa Asp Leu Gly Ala Ile Val Tyr Cys Val Gly Val Lys Asp Phe Asn 
1               5                   10                  15      


Glu Xaa Gln Leu Ala Arg Ile Ala Asp Ser Lys Asp His Val Phe Pro 
            20                  25                  30          


Val Asn Asp Gly Phe Gln Ala Leu Gln Gly Ile Ile His Ser Ile Leu 
        35                  40                  45              


Lys Lys Ser Cys Ile Glu Ile Leu Ala Ala Glu Pro Ser Xaa Ile Cys 
    50                  55                  60                  


Ala Gly Glu Ser Phe Gln Val Val Val Arg Gly Asn Gly Phe Arg His 
65                  70                  75                  80  


Ala Arg Asn Val Asp Arg Val Leu Cys Ser Phe Lys Ile Asn Asp Ser 
                85                  90                  95      


Val Xaa Leu Asn Glu Lys Pro Phe Ser Val Glu Asp Xaa Tyr Leu Leu 
            100                 105                 110         


Cys Pro Ala Pro Ile Leu Lys Glu Val Gly Met Lys Ala Ala Leu Gln 
        115                 120                 125             


Val Ser Met Asn Asp Gly Leu Ser Phe Ile Ser Ser Ser Val Ile Ile 
    130                 135                 140                 


Xaa Xaa Xaa His Cys Asp Gly Leu Trp Phe Tyr Ile Gln Ser Leu Glu 
145                 150                 155                 160 


Xaa Val Lys Asp His Arg Asn Ile Arg Val Arg Asn Ser Asp Leu Lys 
                165                 170                 175     


Tyr Cys Leu 
            


<210> 2412
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<400> 2412
Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Xaa Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Xaa Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Xaa 
    50                  55                  60                  


Ile Ile Asp Ile Leu Xaa Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Xaa Gly Lys Pro Leu Asp Glu Xaa Leu 
                85                  90                  95      


Lys Lys Ala Leu Xaa Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Xaa Pro 
        115 


<210> 2413
<211> 346
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<400> 2413
Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Xaa Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Xaa Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Xaa 
    50                  55                  60                  


Ile Ile Asp Ile Leu Xaa Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Xaa Gly Lys Pro Leu Asp Glu Xaa Leu 
                85                  90                  95      


Lys Lys Ala Leu Xaa Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Xaa Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Xaa Asp Glu Asp Xaa Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Xaa Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Xaa Ser Asp Xaa Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Xaa Asp Val Asn Val Phe Asn Xaa Ile 
    210                 215                 220                 


Leu Xaa Xaa Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Xaa Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Xaa Ala Ile Val Lys Cys Ala Xaa 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Xaa Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Xaa Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210> 2414
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<400> 2414
Met Asn Leu Ile Leu Arg Tyr Xaa Phe Ser Lys Met Ala Met Val Ser 
1               5                   10                  15      


Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn Glu Glu Gln Glu Tyr 
            20                  25                  30          


Val Gln Xaa Val Lys Ser Ser Lys Gly Gly Pro Gly Ser Ala Val Ser 
        35                  40                  45              


Pro Tyr Pro Xaa Phe Asn Pro Ser Ser Asp Val Ala Ala Leu His Lys 
    50                  55                  60                  


Ala Ile Met Val Lys Gly Val Asp Glu Ala Xaa Ile Ile Asp Ile Leu 
65                  70                  75                  80  


Xaa Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile Lys Ala Ala Tyr Leu 
                85                  90                  95      


Gln Glu Xaa Gly Lys Pro Leu Asp Glu Xaa Leu Lys Lys Ala Leu Xaa 
            100                 105                 110         


Gly His Leu Glu Glu Val Val Leu Ala Leu Leu Lys Xaa Pro Ala Gln 
        115                 120                 125             


Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys Gly Leu Gly Xaa Asp 
    130                 135                 140                 


Glu Asp Xaa Leu Ile Glu Ile Leu Ala Ser Arg Xaa Asn Lys Glu Ile 
145                 150                 155                 160 


Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu Lys Arg Asp Leu Ala 
                165                 170                 175     


Lys Asp Ile Xaa Ser Asp Xaa Ser Gly Asp Phe Arg Asn Ala Leu Leu 
            180                 185                 190         


Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe Gly 
        195                 200                 


<210> 2415
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<400> 2415
Met Ala Ser Ile Trp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu 
1               5                   10                  15      


His Leu Ala Lys Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn 
            20                  25                  30          


Arg Trp Gly Xaa Asp Glu Asp Lys Phe Xaa Glu Ile Leu Cys Leu Arg 
        35                  40                  45              


Ser Phe Pro Gln Leu Lys Leu 
    50                  55  


<210> 2416
<211> 104
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 2416
Met Ala Ser Ile Trp Val Gly His Arg Gly Xaa Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Xaa Asp Glu Lys Met Leu Ile Ser Ile Leu Xaa Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Xaa Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys 
            100                 


<210> 2417
<211> 134
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<400> 2417
Met Ala Ser Ile Trp Val Gly His Arg Gly Xaa Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Xaa Asp Glu Lys Met Leu Ile Ser Ile Leu Xaa Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Xaa Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Xaa Asn Glu Asp Ala 
            100                 105                 110         


Leu Ile Glu Ile Leu Xaa Xaa Arg Xaa Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125             


Ser Gln Ala Tyr Tyr Xaa 
    130                 


<210> 2418
<211> 154
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 2418
Met Ala Ser Ile Trp Val Gly His Arg Gly Xaa Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Xaa Asp Glu Lys Met Leu Ile Ser Ile Leu Xaa Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Xaa Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Xaa Asn Glu Asp Ala 
            100                 105                 110         


Leu Ile Glu Ile Leu Xaa Xaa Arg Xaa Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125             


Ser Gln Ala Tyr Tyr Xaa Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140                 


Ser Ser Glu Xaa Ser Gly Asp Phe Arg Lys 
145                 150                 


<210> 2419
<211> 323
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<400> 2419
Met Ala Ser Ile Trp Val Gly His Arg Gly Xaa Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Xaa Asp Glu Lys Met Leu Ile Ser Ile Leu Xaa Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Xaa Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Xaa Asn Glu Asp Ala 
            100                 105                 110         


Leu Ile Glu Ile Leu Xaa Xaa Arg Xaa Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125             


Ser Gln Ala Tyr Tyr Xaa Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140                 


Ser Ser Glu Xaa Ser Gly Asp Phe Arg Lys Ala Leu Leu Xaa Leu Ala 
145                 150                 155                 160 


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175     


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Xaa 
            180                 185                 190         


Asp Glu Asp Lys Phe Xaa Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205             


Leu Lys Leu Xaa Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220                 


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240 


Leu Ala Ile Val Asn Cys Val Arg Asn Xaa Pro Ala Phe Leu Ala Glu 
                245                 250                 255     


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Xaa Asp Glu Phe Xaa Leu 
            260                 265                 270         


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285             


Xaa Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300                 


Ser Asp Xaa Ser Gly Asp Tyr Glu Ile Xaa Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320 


Gly Asp Asp 
            


<210> 2420
<211> 284
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<400> 2420
Met Leu Ile Ser Ile Leu Xaa Glu Arg Ser Asn Ala Gln Arg Gln Leu 
1               5                   10                  15      


Ile Val Lys Glu Tyr Gln Ala Ala Tyr Gly Lys Glu Leu Lys Asp Asp 
            20                  25                  30          


Leu Lys Gly Asp Leu Ser Gly His Phe Glu His Leu Met Val Ala Leu 
        35                  40                  45              


Val Xaa Pro Pro Ala Val Phe Asp Ala Lys Gln Leu Lys Lys Ser Met 
    50                  55                  60                  


Lys Gly Ala Gly Xaa Asn Glu Asp Ala Leu Ile Glu Ile Leu Xaa Xaa 
65                  70                  75                  80  


Arg Xaa Ser Arg Gln Met Lys Asp Ile Ser Gln Ala Tyr Tyr Xaa Val 
                85                  90                  95      


Tyr Lys Lys Ser Leu Gly Asp Asp Ile Ser Ser Glu Xaa Ser Gly Asp 
            100                 105                 110         


Phe Arg Lys Ala Leu Leu Xaa Leu Ala Asp Gly Arg Arg Asp Glu Ser 
        115                 120                 125             


Leu Lys Val Asp Glu His Leu Ala Lys Gln Asp Ala Gln Ile Leu Tyr 
    130                 135                 140                 


Lys Ala Gly Glu Asn Arg Trp Gly Xaa Asp Glu Asp Lys Phe Xaa Glu 
145                 150                 155                 160 


Ile Leu Cys Leu Arg Ser Phe Pro Gln Leu Lys Leu Xaa Phe Asp Glu 
                165                 170                 175     


Tyr Arg Asn Ile Ser Gln Lys Asp Ile Val Asp Ser Ile Lys Gly Glu 
            180                 185                 190         


Leu Ser Gly His Phe Glu Asp Leu Leu Leu Ala Ile Val Asn Cys Val 
        195                 200                 205             


Arg Asn Xaa Pro Ala Phe Leu Ala Glu Arg Leu His Arg Ala Leu Lys 
    210                 215                 220                 


Gly Ile Gly Xaa Asp Glu Phe Xaa Leu Asn Arg Ile Met Val Ser Arg 
225                 230                 235                 240 


Ser Glu Ile Asp Leu Leu Asp Ile Arg Xaa Glu Phe Lys Lys His Tyr 
                245                 250                 255     


Gly Tyr Ser Leu Tyr Ser Ala Ile Lys Ser Asp Xaa Ser Gly Asp Tyr 
            260                 265                 270         


Glu Ile Xaa Leu Leu Lys Ile Cys Gly Gly Asp Asp 
        275                 280                 


<210> 2421
<211> 299
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<400> 2421
Met Ala Met Ala Xaa Lys Gly Gly Xaa Val Lys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Asn Ala Met Glu Asp Ala Gln Xaa Leu Arg Lys Ala Met Lys Gly Leu 
            20                  25                  30          


Gly Xaa Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Xaa 
        35                  40                  45              


Ala Gln Arg Gln Glu Ile Arg Xaa Ala Tyr Lys Ser Xaa Ile Gly Arg 
    50                  55                  60                  


Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln 
65                  70                  75                  80  


Gly Ala Gly Xaa Asp Glu Gly Cys Leu Ile Glu Ile Leu Ala Ser Arg 
                85                  90                  95      


Xaa Pro Glu Glu Ile Arg Arg Ile Ser Gln Xaa Tyr Gln Gln Gln Tyr 
            100                 105                 110         


Gly Arg Ser Leu Glu Asp Asp Ile Arg Ser Asp Xaa Ser Phe Met Phe 
        115                 120                 125             


Gln Arg Val Leu Val Ser Leu Ser Ala Gly Gly Arg Asp Glu Gly Asn 
    130                 135                 140                 


Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp Ala Gln Asp Leu Tyr Glu 
145                 150                 155                 160 


Ala Gly Glu Lys Lys Trp Gly Xaa Asp Glu Val Lys Phe Leu Xaa Val 
                165                 170                 175     


Leu Cys Ser Arg Asn Arg Asn His Leu Leu His Val Phe Asp Glu Tyr 
            180                 185                 190         


Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln Ser Ile Lys Ser Glu Xaa 
        195                 200                 205             


Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala Ile Val Lys Cys Met Arg 
    210                 215                 220                 


Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu Tyr Lys Ser Met Lys Gly 
225                 230                 235                 240 


Leu Gly Xaa Asp Asp Asn Xaa Leu Ile Arg Val Met Val Ser Arg Ala 
                245                 250                 255     


Glu Ile Asp Met Leu Asp Ile Arg Ala His Phe Lys Arg Leu Tyr Gly 
            260                 265                 270         


Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp Xaa Ser Gly Asp Tyr Arg 
        275                 280                 285             


Lys Val Leu Leu Val Leu Cys Gly Gly Asp Asp 
    290                 295                 


<210> 2422
<211> 142
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<400> 2422
Met Ala Met Ala Xaa Lys Gly Gly Xaa Val Lys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Asn Ala Met Glu Asp Ala Gln Xaa Leu Arg Lys Ala Met Lys Gly Leu 
            20                  25                  30          


Gly Xaa Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Xaa 
        35                  40                  45              


Ala Gln Arg Gln Glu Ile Arg Xaa Ala Tyr Lys Ser Xaa Ile Gly Arg 
    50                  55                  60                  


Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln 
65                  70                  75                  80  


Gly Ala Gly Xaa Asp Glu Gly Cys Leu Ile Glu Ile Leu Ala Ser Arg 
                85                  90                  95      


Xaa Pro Glu Glu Ile Arg Arg Ile Ser Gln Xaa Tyr Gln Gln Gln Tyr 
            100                 105                 110         


Gly Arg Ser Leu Glu Asp Asp Ile Arg Ser Asp Xaa Ser Phe Met Phe 
        115                 120                 125             


Gln Arg Val Leu Val Ser Leu Ser Ala Val Ser Asp Cys Phe 
    130                 135                 140         


<210> 2423
<211> 321
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<400> 2423
Met Ala Met Ala Xaa Lys Gly Gly Xaa Val Lys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Asn Ala Met Glu Asp Ala Gln Xaa Leu Arg Lys Ala Met Lys Gly Leu 
            20                  25                  30          


Gly Xaa Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Xaa 
        35                  40                  45              


Ala Gln Arg Gln Glu Ile Arg Xaa Ala Tyr Lys Ser Xaa Ile Gly Arg 
    50                  55                  60                  


Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln 
65                  70                  75                  80  


Val Ile Val Gly Met Met Xaa Pro Xaa Val Leu Tyr Asp Val Gln Glu 
                85                  90                  95      


Leu Arg Arg Ala Met Lys Gly Ala Gly Xaa Asp Glu Gly Cys Leu Ile 
            100                 105                 110         


Glu Ile Leu Ala Ser Arg Xaa Pro Glu Glu Ile Arg Arg Ile Ser Gln 
        115                 120                 125             


Xaa Tyr Gln Gln Gln Tyr Gly Arg Ser Leu Glu Asp Asp Ile Arg Ser 
    130                 135                 140                 


Asp Xaa Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly 
145                 150                 155                 160 


Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp 
                165                 170                 175     


Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Xaa Asp Glu 
            180                 185                 190         


Val Lys Phe Leu Xaa Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu 
        195                 200                 205             


His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln 
    210                 215                 220                 


Ser Ile Lys Ser Glu Xaa Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala 
225                 230                 235                 240 


Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu 
                245                 250                 255     


Tyr Lys Ser Met Lys Gly Leu Gly Xaa Asp Asp Asn Xaa Leu Ile Arg 
            260                 265                 270         


Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala His 
        275                 280                 285             


Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp 
    290                 295                 300                 


Xaa Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly Asp 
305                 310                 315                 320 


Asp 
    


<210> 2424
<211> 8
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<400> 2424
Ser Gln Xaa Tyr Gln Gln Arg Xaa 
1               5               


<210> 2425
<211> 7
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<400> 2425
Xaa Xaa Tyr Gln Gln Arg Xaa 
1               5           


<210> 2426
<211> 260
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<400> 2426
Met Ala Gln Asp Leu Leu Asp Asp Leu Lys Ser Glu Leu Xaa Gly Lys 
1               5                   10                  15      


Phe Glu Lys Leu Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp 
            20                  25                  30          


Ala Tyr Glu Leu Lys His Ala Leu Lys Gly Ala Gly Xaa Asn Glu Lys 
        35                  40                  45              


Val Leu Xaa Glu Ile Ile Ala Ser Arg Xaa Pro Glu Glu Leu Arg Ala 
    50                  55                  60                  


Ile Lys Gln Val Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp 
65                  70                  75                  80  


Val Val Gly Asp Xaa Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu 
                85                  90                  95      


Leu Gln Ala Asn Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val 
            100                 105                 110         


Glu Gln Asp Ala Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly 
        115                 120                 125             


Xaa Asp Glu Glu Lys Phe Ile Xaa Ile Phe Gly Xaa Arg Ser Val Ser 
    130                 135                 140                 


His Leu Arg Lys Val Phe Asp Lys Tyr Met Xaa Ile Ser Gly Phe Gln 
145                 150                 155                 160 


Ile Glu Glu Xaa Ile Asp Arg Glu Xaa Ser Gly Asn Leu Glu Gln Leu 
                165                 170                 175     


Leu Leu Ala Val Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala 
            180                 185                 190         


Glu Xaa Leu Tyr Tyr Ala Met Lys Gly Ala Gly Xaa Asp Asp His Xaa 
        195                 200                 205             


Leu Ile Arg Val Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile 
    210                 215                 220                 


Arg Lys Glu Phe Arg Lys Asn Phe Ala Xaa Ser Leu Tyr Ser Met Ile 
225                 230                 235                 240 


Lys Gly Asp Xaa Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys 
                245                 250                 255     


Gly Glu Asp Asp 
            260 


<210> 2427
<211> 220
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<400> 2427
Met Ala Gln Val Leu Arg Gly Xaa Val Xaa Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Xaa Leu Arg Lys Ala Met Lys Gly Leu Glu 
            20                  25                  30          


Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp Xaa Ser Gly Tyr 
        35                  40                  45              


Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn Arg Asp Pro Asp 
    50                  55                  60                  


Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala Gln Ala Leu Phe 
65                  70                  75                  80  


Gln Ala Gly Glu Leu Lys Trp Gly Xaa Asp Glu Glu Lys Phe Ile Xaa 
                85                  90                  95      


Ile Phe Gly Xaa Arg Ser Val Ser His Leu Arg Lys Val Phe Asp Lys 
            100                 105                 110         


Tyr Met Xaa Ile Ser Gly Phe Gln Ile Glu Glu Xaa Ile Asp Arg Glu 
        115                 120                 125             


Xaa Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val Val Lys Ser Ile 
    130                 135                 140                 


Arg Ser Ile Pro Ala Tyr Leu Ala Glu Xaa Leu Tyr Tyr Ala Met Lys 
145                 150                 155                 160 


Gly Ala Gly Xaa Asp Asp His Xaa Leu Ile Arg Val Met Val Ser Arg 
                165                 170                 175     


Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe Arg Lys Asn Phe 
            180                 185                 190         


Ala Xaa Ser Leu Tyr Ser Met Ile Lys Gly Asp Xaa Ser Gly Asp Tyr 
        195                 200                 205             


Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
    210                 215                 220 


<210> 2428
<211> 35
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<400> 2428
Met Ala Gln Val Leu Arg Gly Xaa Val Xaa Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Xaa Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Ser Ser Gly 
        35  


<210> 2429
<211> 320
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<400> 2429
Met Ala Gln Val Leu Arg Gly Xaa Val Xaa Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Xaa Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Xaa Asp Glu Glu Ser Ile Leu Xaa Leu Leu Xaa Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Xaa Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Xaa Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Xaa Asn Glu Lys Val Leu Xaa Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Xaa Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Xaa Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Xaa Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Xaa Ile Phe Gly Xaa Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Xaa Ile Ser Gly Phe Gln Ile Glu Glu Xaa 
    210                 215                 220                 


Ile Asp Arg Glu Xaa Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Xaa Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Xaa Asp Asp His Xaa Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Xaa Ser Leu Tyr Ser Met Ile Lys Gly Asp Xaa 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


<210> 2430
<211> 163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<400> 2430
Met Ala Gln Val Leu Arg Gly Xaa Val Xaa Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Xaa Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Xaa Asp Glu Glu Ser Ile Leu Xaa Leu Leu Xaa Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Xaa Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Xaa Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Xaa Asn Glu Lys Val Leu Xaa Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Xaa Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Xaa Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Val Leu 
145                 150                 155                 160 


Arg Gly Asp 
            


<210> 2431
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 2431
Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Xaa Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Xaa 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Xaa Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Gly Leu Ser Asp Val Gly Xaa 
                85                  90                  95  


<210> 2432
<211> 156
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 2432
Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Xaa Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Xaa 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Xaa Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ala Gly Xaa Asp Glu 
            100                 105                 110         


Lys Xaa Leu Xaa Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu 
        115                 120                 125             


Asn Ile Arg Arg Glu Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln 
    130                 135                 140                 


Ala Ile Glu Gly Asp Xaa Ser Gly Asp Phe Leu Lys 
145                 150                 155     


<210> 2433
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 2433
Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Xaa Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Xaa 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Xaa Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Xaa 
            100                 105                 110 


<210> 2434
<211> 673
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<400> 2434
Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Xaa Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Xaa 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Xaa Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Xaa Asp Glu 
            100                 105                 110         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Xaa Asn Glu Gln Met His 
        115                 120                 125             


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
    130                 135                 140                 


Asp Ile Ile Gly Asp Xaa Ser Gly His Phe Gln Lys Met Leu Val Val 
145                 150                 155                 160 


Leu Leu Gln Gly Xaa Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
                165                 170                 175     


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
            180                 185                 190         


Gly Xaa Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
        195                 200                 205             


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Xaa Xaa Gly Lys 
    210                 215                 220                 


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
225                 230                 235                 240 


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Xaa Pro Glu Tyr Phe 
                245                 250                 255     


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Xaa Arg Asp Asn 
            260                 265                 270         


Xaa Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
        275                 280                 285             


Ile Arg Glu Ile Phe Arg Xaa Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
    290                 295                 300                 


Ile Lys Asn Asp Xaa Ser Gly Glu Tyr Lys Lys Xaa Leu Leu Lys Leu 
305                 310                 315                 320 


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
                325                 330                 335     


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
            340                 345                 350         


Leu Lys Gly Xaa Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
        355                 360                 365             


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Xaa Asp Glu Asp 
    370                 375                 380                 


Xaa Ile Ile Asp Ile Ile Xaa His Arg Ser Asn Val Gln Arg Gln Gln 
385                 390                 395                 400 


Ile Arg Gln Xaa Phe Lys Ser His Phe Gly Arg Asp Leu Met Xaa Asp 
                405                 410                 415     


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
            420                 425                 430         


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
        435                 440                 445             


Glu Gly Ala Gly Xaa Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Xaa 
    450                 455                 460                 


Arg Xaa Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
465                 470                 475                 480 


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Xaa Ser Gly His 
                485                 490                 495     


Phe Arg Arg Ile Leu Ile Ser Leu Ala Xaa Gly His Arg Glu Glu Gly 
            500                 505                 510         


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu 
        515                 520                 525             


Ile Leu Glu Ile Ala Asp Xaa Pro Ser Gly Asp Lys Xaa Ser Leu Glu 
    530                 535                 540                 


Xaa Arg Phe Met Xaa Ile Leu Cys Xaa Arg Ser Tyr Pro His Leu Arg 
545                 550                 555                 560 


Arg Val Phe Gln Glu Phe Ile Lys Met Xaa Asn Tyr Asp Val Glu His 
                565                 570                 575     


Xaa Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala 
            580                 585                 590         


Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu 
        595                 600                 605             


Tyr Lys Ser Met Lys Gly Ala Gly Xaa Asp Glu Lys Xaa Leu Xaa Arg 
    610                 615                 620                 


Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp 
                645                 650                 655     


Xaa Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu 
            660                 665                 670         


Asp 
    


<210> 2435
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<400> 2435
Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Xaa Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Xaa 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Xaa Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Xaa Asp Glu 
            100                 105                 110         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Xaa Tyr Xaa Arg Gln Gly 
        115                 120                 125             


Asn 
    


<210> 2436
<211> 460
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<400> 2436
Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Xaa Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Xaa 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Asn Glu Leu Asp Met Leu 
65                  70                  75                  80  


Asp Ile Arg Glu Ile Phe Arg Xaa Lys Tyr Glu Lys Ser Leu Tyr Ser 
                85                  90                  95      


Met Ile Lys Asn Asp Xaa Ser Gly Glu Tyr Lys Lys Xaa Leu Leu Lys 
            100                 105                 110         


Leu Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala 
        115                 120                 125             


Ala Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val 
    130                 135                 140                 


Glu Leu Lys Gly Xaa Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala 
145                 150                 155                 160 


Asp Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Xaa Asp Glu 
                165                 170                 175     


Asp Xaa Ile Ile Asp Ile Ile Xaa His Arg Ser Asn Val Gln Arg Gln 
            180                 185                 190         


Gln Ile Arg Gln Xaa Phe Lys Ser His Phe Gly Arg Asp Leu Met Xaa 
        195                 200                 205             


Asp Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly 
    210                 215                 220                 


Leu Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala 
225                 230                 235                 240 


Met Glu Gly Ala Gly Xaa Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala 
                245                 250                 255     


Xaa Arg Xaa Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu 
            260                 265                 270         


Asp Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Xaa Ser Gly 
        275                 280                 285             


His Phe Arg Arg Ile Leu Ile Ser Leu Ala Xaa Gly His Arg Glu Glu 
    290                 295                 300                 


Gly Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Glu Ile Ala 
305                 310                 315                 320 


Asp Xaa Pro Ser Gly Asp Lys Xaa Ser Leu Glu Xaa Arg Phe Met Xaa 
                325                 330                 335     


Ile Leu Cys Xaa Arg Ser Tyr Pro His Leu Arg Arg Val Phe Gln Glu 
            340                 345                 350         


Phe Ile Lys Met Xaa Asn Tyr Asp Val Glu His Xaa Ile Lys Lys Glu 
        355                 360                 365             


Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala Ile Val Gln Ser Val 
    370                 375                 380                 


Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu Tyr Lys Ser Met Lys 
385                 390                 395                 400 


Gly Ala Gly Xaa Asp Glu Lys Xaa Leu Xaa Arg Ile Met Val Ser Arg 
                405                 410                 415     


Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu Phe Ile Glu Lys Tyr 
            420                 425                 430         


Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp Xaa Ser Gly Asp Phe 
        435                 440                 445             


Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu Asp 
    450                 455                 460 


<210> 2437
<211> 330
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<400> 2437
Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Xaa Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Xaa 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Met Xaa Asp Leu Lys Ser Glu Ile Ser Gly 
65                  70                  75                  80  


Asp Leu Ala Arg Leu Ile Leu Gly Leu Met Met Pro Pro Ala His Tyr 
                85                  90                  95      


Asp Ala Lys Gln Leu Lys Lys Ala Met Glu Gly Ala Gly Xaa Asp Glu 
            100                 105                 110         


Lys Ala Leu Ile Glu Ile Leu Ala Xaa Arg Xaa Asn Ala Glu Ile Arg 
        115                 120                 125             


Ala Ile Asn Glu Ala Tyr Lys Glu Asp Tyr His Lys Ser Leu Glu Asp 
    130                 135                 140                 


Ala Leu Ser Ser Asp Xaa Ser Gly His Phe Arg Arg Ile Leu Ile Ser 
145                 150                 155                 160 


Leu Ala Xaa Gly His Arg Glu Glu Gly Gly Glu Asn Leu Asp Gln Ala 
                165                 170                 175     


Arg Glu Asp Ala Gln Val Ala Ala Glu Ile Leu Glu Ile Ala Asp Xaa 
            180                 185                 190         


Pro Ser Gly Asp Lys Xaa Ser Leu Glu Xaa Arg Phe Met Xaa Ile Leu 
        195                 200                 205             


Cys Xaa Arg Ser Tyr Pro His Leu Arg Arg Val Phe Gln Glu Phe Ile 
    210                 215                 220                 


Lys Met Xaa Asn Tyr Asp Val Glu His Xaa Ile Lys Lys Glu Met Ser 
225                 230                 235                 240 


Gly Asp Val Arg Asp Ala Phe Val Ala Ile Val Gln Ser Val Lys Asn 
                245                 250                 255     


Lys Pro Leu Phe Phe Ala Asp Lys Leu Tyr Lys Ser Met Lys Gly Ala 
            260                 265                 270         


Gly Xaa Asp Glu Lys Xaa Leu Xaa Arg Ile Met Val Ser Arg Ser Glu 
        275                 280                 285             


Ile Asp Leu Leu Asn Ile Arg Arg Glu Phe Ile Glu Lys Tyr Asp Lys 
    290                 295                 300                 


Ser Leu His Gln Ala Ile Glu Gly Asp Xaa Ser Gly Asp Phe Leu Lys 
305                 310                 315                 320 


Ala Leu Leu Ala Leu Cys Gly Gly Glu Asp 
                325                 330 


<210> 2438
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<400> 2438
Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Xaa 
1               5                   10                  15      


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
            20                  25                  30          


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Xaa Gly 
        35                  40                  45              


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
    50                  55                  60                  


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Xaa Asp Glu 
65                  70                  75                  80  


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Xaa Asn Glu Gln Met His 
                85                  90                  95      


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
            100                 105                 110         


Asp Ile Ile Gly Asp Xaa Ser Gly His Phe Gln Lys Met Leu Val Val 
        115                 120                 125             


Leu Leu 
    130 


<210> 2439
<211> 150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<400> 2439
Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Xaa 
1               5                   10                  15      


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
            20                  25                  30          


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Xaa Gly 
        35                  40                  45              


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
    50                  55                  60                  


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Xaa Asp Glu 
65                  70                  75                  80  


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Xaa Asn Glu Gln Met His 
                85                  90                  95      


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
            100                 105                 110         


Asp Ile Ile Gly Asp Xaa Ser Gly His Phe Gln Lys Met Leu Val Val 
        115                 120                 125             


Leu Leu Gln Gly Xaa Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
    130                 135                 140                 


Val Gln Gln Asp Val Gln 
145                 150 


<210> 2440
<211> 641
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<400> 2440
Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Xaa 
1               5                   10                  15      


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
            20                  25                  30          


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Xaa Gly 
        35                  40                  45              


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
    50                  55                  60                  


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Xaa Asp Glu 
65                  70                  75                  80  


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Xaa Asn Glu Gln Met His 
                85                  90                  95      


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
            100                 105                 110         


Asp Ile Ile Gly Asp Xaa Ser Gly His Phe Gln Lys Met Leu Val Val 
        115                 120                 125             


Leu Leu Gln Gly Xaa Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
    130                 135                 140                 


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
145                 150                 155                 160 


Gly Xaa Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
                165                 170                 175     


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Xaa Xaa Gly Lys 
            180                 185                 190         


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
        195                 200                 205             


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Xaa Pro Glu Tyr Phe 
    210                 215                 220                 


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Xaa Arg Asp Asn 
225                 230                 235                 240 


Xaa Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
                245                 250                 255     


Ile Arg Glu Ile Phe Arg Xaa Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
            260                 265                 270         


Ile Lys Asn Asp Xaa Ser Gly Glu Tyr Lys Lys Xaa Leu Leu Lys Leu 
        275                 280                 285             


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
    290                 295                 300                 


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
305                 310                 315                 320 


Leu Lys Gly Xaa Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
                325                 330                 335     


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Xaa Asp Glu Asp 
            340                 345                 350         


Xaa Ile Ile Asp Ile Ile Xaa His Arg Ser Asn Val Gln Arg Gln Gln 
        355                 360                 365             


Ile Arg Gln Xaa Phe Lys Ser His Phe Gly Arg Asp Leu Met Xaa Asp 
    370                 375                 380                 


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
385                 390                 395                 400 


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
                405                 410                 415     


Glu Gly Ala Gly Xaa Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Xaa 
            420                 425                 430         


Arg Xaa Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
        435                 440                 445             


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Xaa Ser Gly His 
    450                 455                 460                 


Phe Arg Arg Ile Leu Ile Ser Leu Ala Xaa Gly His Arg Glu Glu Gly 
465                 470                 475                 480 


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu 
                485                 490                 495     


Ile Leu Glu Ile Ala Asp Xaa Pro Ser Gly Asp Lys Xaa Ser Leu Glu 
            500                 505                 510         


Xaa Arg Phe Met Xaa Ile Leu Cys Xaa Arg Ser Tyr Pro His Leu Arg 
        515                 520                 525             


Arg Val Phe Gln Glu Phe Ile Lys Met Xaa Asn Tyr Asp Val Glu His 
    530                 535                 540                 


Xaa Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala 
545                 550                 555                 560 


Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu 
                565                 570                 575     


Tyr Lys Ser Met Lys Gly Ala Gly Xaa Asp Glu Lys Xaa Leu Xaa Arg 
            580                 585                 590         


Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu 
        595                 600                 605             


Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp 
    610                 615                 620                 


Xaa Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu 
625                 630                 635                 640 


Asp 
    


<210> 2441
<211> 91
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 2441
Xaa Ala Asp Lys Leu Tyr Lys Ser Met Lys Gly Ala Gly Xaa Asp Glu 
1               5                   10                  15      


Lys Xaa Leu Xaa Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu 
            20                  25                  30          


Asn Ile Arg Arg Glu Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln 
        35                  40                  45              


Ala Ile Glu Gly Asp Xaa Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala 
    50                  55                  60                  


Leu Cys Gly Gly Arg Ala Arg Val Leu Asp Gln Glu Phe Gly Cys Leu 
65                  70                  75                  80  


Gly Ser Asn Leu His Leu Pro Cys Xaa Cys Phe 
                85                  90      


<210> 2442
<211> 345
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<400> 2442
Met Ser Val Xaa Gly Gly Lys Met Ala Pro Ser Leu Xaa Gln Glu Ile 
1               5                   10                  15      


Leu Ser His Leu Gly Leu Ala Ser Lys Xaa Ala Ala Trp Gly Xaa Leu 
            20                  25                  30          


Gly Xaa Leu Arg Xaa Phe Leu Asn Phe Ser Val Asp Lys Asp Ala Gln 
        35                  40                  45              


Arg Leu Leu Arg Ala Ile Xaa Gly Gln Gly Val Asp Arg Ser Ala Ile 
    50                  55                  60                  


Val Asp Val Leu Xaa Asn Arg Ser Arg Glu Gln Arg Gln Leu Ile Ser 
65                  70                  75                  80  


Arg Asn Phe Gln Glu Arg Xaa Gln Gln Asp Leu Met Lys Ser Leu Gln 
                85                  90                  95      


Ala Ala Leu Ser Gly Asn Leu Glu Arg Ile Val Met Ala Leu Leu Gln 
            100                 105                 110         


Pro Xaa Ala Gln Phe Asp Ala Gln Glu Leu Arg Xaa Ala Leu Lys Ala 
        115                 120                 125             


Ser Asp Ser Ala Val Asp Val Ala Ile Glu Ile Leu Ala Xaa Arg Xaa 
    130                 135                 140                 


Pro Pro Gln Leu Gln Glu Cys Leu Ala Val Tyr Lys His Asn Phe Gln 
145                 150                 155                 160 


Val Glu Ala Val Asp Asp Ile Xaa Ser Glu Xaa Ser Gly Ile Leu Gln 
                165                 170                 175     


Asp Leu Leu Leu Ala Leu Ala Lys Gly Gly Arg Asp Ser Tyr Ser Gly 
            180                 185                 190         


Ile Ile Asp Tyr Asn Leu Ala Glu Gln Asp Val Gln Ala Leu Gln Arg 
        195                 200                 205             


Ala Glu Gly Pro Ser Arg Glu Glu Xaa Trp Val Pro Val Phe Xaa Gln 
    210                 215                 220                 


Arg Asn Pro Glu His Leu Ile Arg Val Phe Asp Gln Tyr Gln Arg Ser 
225                 230                 235                 240 


Xaa Gly Gln Glu Leu Glu Glu Ala Val Gln Asn Arg Phe His Gly Asp 
                245                 250                 255     


Ala Gln Val Ala Leu Leu Gly Leu Ala Ser Val Ile Lys Asn Xaa Pro 
            260                 265                 270         


Leu Tyr Phe Ala Asp Lys Leu His Gln Ala Leu Gln Glu Xaa Glu Pro 
        275                 280                 285             


Asn Tyr Gln Val Leu Ile Arg Ile Leu Ile Ser Arg Cys Glu Xaa Asp 
    290                 295                 300                 


Leu Leu Ser Ile Arg Ala Glu Phe Arg Lys Lys Phe Gly Lys Ser Leu 
305                 310                 315                 320 


Tyr Ser Ser Leu Gln Asp Ala Val Lys Gly Asp Cys Gln Ser Ala Leu 
                325                 330                 335     


Leu Ala Leu Cys Arg Ala Glu Asp Met 
            340                 345 


<210> 2443
<211> 955
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<400> 2443
Met Pro Ala Val Ser Lys Gly Asp Gly Met Arg Gly Leu Ala Val Phe 
1               5                   10                  15      


Ile Ser Asp Ile Arg Asn Cys Lys Ser Lys Glu Ala Glu Ile Lys Arg 
            20                  25                  30          


Ile Asn Lys Glu Leu Ala Asn Ile Arg Ser Lys Phe Lys Gly Asp Lys 
        35                  40                  45              


Ala Leu Asp Gly Tyr Ser Lys Lys Lys Tyr Val Cys Lys Leu Leu Phe 
    50                  55                  60                  


Ile Phe Leu Leu Gly His Asp Ile Asp Phe Gly His Met Glu Ala Val 
65                  70                  75                  80  


Asn Leu Leu Ser Ser Asn Lys Tyr Xaa Glu Lys Gln Ile Gly Tyr Leu 
                85                  90                  95      


Phe Ile Ser Val Leu Val Asn Ser Asn Ser Glu Leu Ile Arg Leu Ile 
            100                 105                 110         


Asn Asn Ala Ile Lys Asn Asp Leu Ala Ser Arg Asn Pro Xaa Phe Met 
        115                 120                 125             


Cys Leu Ala Leu His Cys Ile Ala Asn Val Gly Ser Arg Glu Met Gly 
    130                 135                 140                 


Glu Ala Phe Ala Ala Asp Ile Pro Arg Ile Leu Val Ala Gly Asp Ser 
145                 150                 155                 160 


Met Asp Ser Val Lys Gln Ser Ala Ala Leu Cys Leu Leu Arg Leu Tyr 
                165                 170                 175     


Lys Ala Ser Pro Asp Leu Val Pro Met Gly Glu Trp Xaa Ala Arg Val 
            180                 185                 190         


Val His Leu Leu Asn Asp Gln His Met Gly Val Val Xaa Ala Ala Val 
        195                 200                 205             


Ser Leu Ile Xaa Cys Leu Cys Lys Lys Asn Pro Asp Asp Phe Lys Xaa 
    210                 215                 220                 


Cys Val Ser Leu Ala Val Ser Arg Leu Ser Arg Ile Val Ser Ser Ala 
225                 230                 235                 240 


Ser Xaa Asp Leu Gln Asp Tyr Xaa Tyr Tyr Phe Val Pro Ala Pro Trp 
                245                 250                 255     


Leu Ser Val Lys Leu Leu Arg Leu Leu Gln Cys Tyr Pro Pro Pro Glu 
            260                 265                 270         


Asp Ala Ala Val Lys Gly Arg Leu Val Glu Cys Leu Glu Xaa Val Leu 
        275                 280                 285             


Asn Lys Ala Gln Glu Pro Pro Lys Ser Lys Lys Val Gln His Ser Asn 
    290                 295                 300                 


Ala Lys Asn Ala Ile Leu Phe Glu Xaa Ile Ser Leu Ile Ile His Tyr 
305                 310                 315                 320 


Asp Ser Glu Pro Asn Leu Leu Val Arg Ala Cys Asn Gln Leu Gly Gln 
                325                 330                 335     


Phe Leu Gln His Arg Glu Xaa Asn Leu Arg Tyr Leu Ala Leu Glu Ser 
            340                 345                 350         


Met Cys Xaa Leu Ala Ser Ser Glu Phe Ser His Glu Ala Val Lys Xaa 
        355                 360                 365             


His Ile Asp Xaa Val Ile Asn Ala Leu Lys Xaa Glu Arg Asp Val Ser 
    370                 375                 380                 


Val Arg Gln Arg Ala Ala Asp Leu Leu Tyr Ala Met Cys Asp Arg Ser 
385                 390                 395                 400 


Asn Ala Lys Gln Ile Val Ser Glu Met Leu Arg Tyr Leu Glu Xaa Ala 
                405                 410                 415     


Asp Tyr Ala Ile Arg Glu Glu Ile Val Leu Lys Val Ala Ile Leu Ala 
            420                 425                 430         


Glu Lys Tyr Ala Val Asp Tyr Ser Trp Tyr Val Asp Xaa Ile Leu Asn 
        435                 440                 445             


Leu Ile Arg Ile Ala Gly Asp Tyr Val Ser Glu Glu Val Trp Tyr Arg 
    450                 455                 460                 


Val Leu Gln Ile Val Xaa Asn Arg Asp Asp Val Gln Gly Tyr Ala Ala 
465                 470                 475                 480 


Lys Xaa Val Phe Glu Ala Leu Gln Ala Pro Ala Cys His Glu Asn Met 
                485                 490                 495     


Val Lys Val Gly Gly Tyr Ile Leu Gly Glu Phe Gly Asn Leu Ile Ala 
            500                 505                 510         


Gly Asp Pro Arg Ser Ser Pro Pro Val Gln Phe Ser Leu Leu His Ser 
        515                 520                 525             


Lys Phe His Leu Cys Ser Val Ala Xaa Arg Ala Leu Leu Leu Ser Xaa 
    530                 535                 540                 


Tyr Ile Lys Phe Ile Asn Leu Phe Pro Glu Xaa Lys Ala Xaa Ile Gln 
545                 550                 555                 560 


Gly Val Leu Arg Ala Gly Ser Gln Leu Arg Asn Ala Asp Val Glu Leu 
                565                 570                 575     


Gln Gln Arg Ala Val Glu Tyr Leu Xaa Leu Ser Ser Val Ala Ser Xaa 
            580                 585                 590         


Asp Val Leu Ala Xaa Val Leu Glu Glu Met Pro Pro Phe Pro Glu Arg 
        595                 600                 605             


Glu Ser Ser Ile Leu Ala Lys Leu Lys Arg Lys Lys Gly Pro Gly Ala 
    610                 615                 620                 


Gly Ser Ala Leu Asp Asp Gly Arg Arg Asp Pro Ser Ser Asn Asp Ile 
625                 630                 635                 640 


Asn Gly Gly Met Glu Pro Xaa Pro Ser Xaa Val Ser Xaa Pro Ser Pro 
                645                 650                 655     


Ser Ala Asp Leu Leu Gly Leu Arg Ala Ala Pro Pro Pro Ala Ala Pro 
            660                 665                 670         


Pro Ala Ser Ala Gly Ala Gly Asn Leu Leu Val Asp Val Phe Asp Gly 
        675                 680                 685             


Pro Ala Ala Gln Pro Ser Leu Gly Pro Xaa Pro Glu Glu Ala Phe Leu 
    690                 695                 700                 


Ser Pro Gly Pro Glu Asp Ile Gly Pro Pro Ile Pro Glu Ala Asp Glu 
705                 710                 715                 720 


Leu Leu Asn Lys Phe Val Cys Lys Asn Asn Gly Val Leu Phe Glu Asn 
                725                 730                 735     


Gln Leu Leu Gln Ile Gly Val Lys Ser Glu Phe Arg Gln Asn Leu Gly 
            740                 745                 750         


Arg Met Tyr Leu Phe Tyr Gly Asn Lys Xaa Ser Val Gln Phe Gln Asn 
        755                 760                 765             


Phe Ser Pro Xaa Val Val His Pro Gly Asp Leu Gln Xaa Gln Leu Ala 
    770                 775                 780                 


Val Gln Xaa Lys Arg Val Ala Ala Gln Val Asp Gly Gly Ala Gln Val 
785                 790                 795                 800 


Gln Gln Val Leu Asn Ile Glu Cys Leu Arg Asp Phe Leu Xaa Pro Pro 
                805                 810                 815     


Leu Leu Ser Val Arg Phe Arg Tyr Gly Gly Ala Pro Gln Ala Leu Xaa 
            820                 825                 830         


Leu Lys Leu Pro Val Xaa Ile Asn Lys Phe Phe Gln Pro Xaa Glu Met 
        835                 840                 845             


Ala Ala Gln Asp Phe Phe Gln Arg Trp Lys Gln Leu Ser Leu Pro Gln 
    850                 855                 860                 


Gln Glu Ala Gln Lys Ile Phe Lys Ala Asn His Pro Met Asp Ala Glu 
865                 870                 875                 880 


Val Xaa Lys Ala Lys Leu Leu Gly Phe Gly Ser Ala Leu Leu Asp Asn 
                885                 890                 895     


Val Asp Pro Asn Pro Glu Asn Phe Val Gly Ala Gly Ile Ile Gln Xaa 
            900                 905                 910         


Lys Ala Leu Gln Val Gly Cys Leu Leu Arg Leu Glu Pro Asn Ala Gln 
        915                 920                 925             


Ala Gln Met Tyr Arg Leu Xaa Leu Arg Xaa Ser Lys Glu Pro Val Ser 
    930                 935                 940                 


Arg His Leu Cys Glu Leu Leu Ala Gln Gln Phe 
945                 950                 955 


<210> 2444
<211> 977
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<400> 2444
Met Pro Ala Val Ser Lys Gly Asp Gly Met Arg Gly Leu Ala Val Phe 
1               5                   10                  15      


Ile Ser Asp Ile Arg Asn Cys Lys Ser Lys Glu Ala Glu Ile Lys Arg 
            20                  25                  30          


Ile Asn Lys Glu Leu Ala Asn Ile Arg Ser Lys Phe Lys Gly Asp Lys 
        35                  40                  45              


Ala Leu Asp Gly Tyr Ser Lys Lys Lys Tyr Val Cys Lys Leu Leu Phe 
    50                  55                  60                  


Ile Phe Leu Leu Gly His Asp Ile Asp Phe Gly His Met Glu Ala Val 
65                  70                  75                  80  


Asn Leu Leu Ser Ser Asn Lys Tyr Xaa Glu Lys Gln Ile Gly Tyr Leu 
                85                  90                  95      


Phe Ile Ser Val Leu Val Asn Ser Asn Ser Glu Leu Ile Arg Leu Ile 
            100                 105                 110         


Asn Asn Ala Ile Lys Asn Asp Leu Ala Ser Arg Asn Pro Xaa Phe Met 
        115                 120                 125             


Cys Leu Ala Leu His Cys Ile Ala Asn Val Gly Ser Arg Glu Met Gly 
    130                 135                 140                 


Glu Ala Phe Ala Ala Asp Ile Pro Arg Ile Leu Val Ala Gly Asp Ser 
145                 150                 155                 160 


Met Asp Ser Val Lys Gln Ser Ala Ala Leu Cys Leu Leu Arg Leu Tyr 
                165                 170                 175     


Lys Ala Ser Pro Asp Leu Val Pro Met Gly Glu Trp Xaa Ala Arg Val 
            180                 185                 190         


Val His Leu Leu Asn Asp Gln His Met Gly Val Val Xaa Ala Ala Val 
        195                 200                 205             


Ser Leu Ile Xaa Cys Leu Cys Lys Lys Asn Pro Asp Asp Phe Lys Xaa 
    210                 215                 220                 


Cys Val Ser Leu Ala Val Ser Arg Leu Ser Arg Ile Val Ser Ser Ala 
225                 230                 235                 240 


Ser Xaa Asp Leu Gln Asp Tyr Xaa Tyr Tyr Phe Val Pro Ala Pro Trp 
                245                 250                 255     


Leu Ser Val Lys Leu Leu Arg Leu Leu Gln Cys Tyr Pro Pro Pro Glu 
            260                 265                 270         


Asp Ala Ala Val Lys Gly Arg Leu Val Glu Cys Leu Glu Xaa Val Leu 
        275                 280                 285             


Asn Lys Ala Gln Glu Pro Pro Lys Ser Lys Lys Val Gln His Ser Asn 
    290                 295                 300                 


Ala Lys Asn Ala Ile Leu Phe Glu Xaa Ile Ser Leu Ile Ile His Tyr 
305                 310                 315                 320 


Asp Ser Glu Pro Asn Leu Leu Val Arg Ala Cys Asn Gln Leu Gly Gln 
                325                 330                 335     


Phe Leu Gln His Arg Glu Xaa Asn Leu Arg Tyr Leu Ala Leu Glu Ser 
            340                 345                 350         


Met Cys Xaa Leu Ala Ser Ser Glu Phe Ser His Glu Ala Val Lys Xaa 
        355                 360                 365             


His Ile Asp Xaa Val Ile Asn Ala Leu Lys Xaa Glu Arg Asp Val Ser 
    370                 375                 380                 


Val Arg Gln Arg Ala Ala Asp Leu Leu Tyr Ala Met Cys Asp Arg Ser 
385                 390                 395                 400 


Asn Ala Lys Gln Ile Val Ser Glu Met Leu Arg Tyr Leu Glu Xaa Ala 
                405                 410                 415     


Asp Tyr Ala Ile Arg Glu Glu Ile Val Leu Lys Val Ala Ile Leu Ala 
            420                 425                 430         


Glu Lys Tyr Ala Val Asp Tyr Ser Trp Tyr Val Asp Xaa Ile Leu Asn 
        435                 440                 445             


Leu Ile Arg Ile Ala Gly Asp Tyr Val Ser Glu Glu Val Trp Tyr Arg 
    450                 455                 460                 


Val Leu Gln Ile Val Xaa Asn Arg Asp Asp Val Gln Gly Tyr Ala Ala 
465                 470                 475                 480 


Lys Xaa Val Phe Glu Ala Leu Gln Ala Pro Ala Cys His Glu Asn Met 
                485                 490                 495     


Val Lys Val Gly Gly Tyr Ile Leu Gly Glu Phe Gly Asn Leu Ile Ala 
            500                 505                 510         


Gly Asp Pro Arg Ser Ser Pro Pro Val Gln Phe Ser Leu Leu His Ser 
        515                 520                 525             


Lys Phe His Leu Cys Ser Val Ala Xaa Arg Ala Leu Leu Leu Ser Xaa 
    530                 535                 540                 


Tyr Ile Lys Phe Ile Asn Leu Phe Pro Glu Xaa Lys Ala Xaa Ile Gln 
545                 550                 555                 560 


Gly Val Leu Arg Ala Gly Ser Gln Leu Arg Asn Ala Asp Val Glu Leu 
                565                 570                 575     


Gln Gln Arg Ala Val Glu Tyr Leu Xaa Leu Ser Ser Val Ala Ser Xaa 
            580                 585                 590         


Asp Val Leu Ala Xaa Val Leu Glu Glu Met Pro Pro Phe Pro Glu Arg 
        595                 600                 605             


Glu Ser Ser Ile Leu Ala Lys Leu Lys Arg Lys Lys Gly Pro Gly Ala 
    610                 615                 620                 


Gly Ser Ala Leu Asp Asp Gly Arg Arg Asp Pro Ser Ser Asn Asp Ile 
625                 630                 635                 640 


Asn Gly Gly Met Glu Pro Xaa Pro Ser Xaa Val Ser Xaa Pro Ser Pro 
                645                 650                 655     


Ser Ala Asp Leu Leu Gly Leu Arg Ala Ala Pro Pro Pro Ala Ala Pro 
            660                 665                 670         


Pro Ala Ser Ala Gly Ala Gly Asn Leu Leu Val Asp Val Phe Asp Gly 
        675                 680                 685             


Pro Ala Ala Gln Pro Ser Leu Gly Pro Xaa Pro Glu Glu Ala Phe Leu 
    690                 695                 700                 


Ser Glu Leu Glu Pro Pro Ala Pro Glu Ser Pro Met Ala Leu Leu Ala 
705                 710                 715                 720 


Asp Pro Ala Pro Ala Ala Asp Pro Gly Pro Glu Asp Ile Gly Pro Pro 
                725                 730                 735     


Ile Pro Glu Ala Asp Glu Leu Leu Asn Lys Phe Val Cys Lys Asn Asn 
            740                 745                 750         


Gly Val Leu Phe Glu Asn Gln Leu Leu Gln Ile Gly Val Lys Ser Glu 
        755                 760                 765             


Phe Arg Gln Asn Leu Gly Arg Met Tyr Leu Phe Tyr Gly Asn Lys Xaa 
    770                 775                 780                 


Ser Val Gln Phe Gln Asn Phe Ser Pro Xaa Val Val His Pro Gly Asp 
785                 790                 795                 800 


Leu Gln Xaa Gln Leu Ala Val Gln Xaa Lys Arg Val Ala Ala Gln Val 
                805                 810                 815     


Asp Gly Gly Ala Gln Val Gln Gln Val Leu Asn Ile Glu Cys Leu Arg 
            820                 825                 830         


Asp Phe Leu Xaa Pro Pro Leu Leu Ser Val Arg Phe Arg Tyr Gly Gly 
        835                 840                 845             


Ala Pro Gln Ala Leu Xaa Leu Lys Leu Pro Val Xaa Ile Asn Lys Phe 
    850                 855                 860                 


Phe Gln Pro Xaa Glu Met Ala Ala Gln Asp Phe Phe Gln Arg Trp Lys 
865                 870                 875                 880 


Gln Leu Ser Leu Pro Gln Gln Glu Ala Gln Lys Ile Phe Lys Ala Asn 
                885                 890                 895     


His Pro Met Asp Ala Glu Val Xaa Lys Ala Lys Leu Leu Gly Phe Gly 
            900                 905                 910         


Ser Ala Leu Leu Asp Asn Val Asp Pro Asn Pro Glu Asn Phe Val Gly 
        915                 920                 925             


Ala Gly Ile Ile Gln Xaa Lys Ala Leu Gln Val Gly Cys Leu Leu Arg 
    930                 935                 940                 


Leu Glu Pro Asn Ala Gln Ala Gln Met Tyr Arg Leu Xaa Leu Arg Xaa 
945                 950                 955                 960 


Ser Lys Glu Pro Val Ser Arg His Leu Cys Glu Leu Leu Ala Gln Gln 
                965                 970                 975     


Phe 
    


<210> 2445
<211> 57
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 2445
Xaa Pro Ala Val Ser Lys Gly Asp Gly Met Arg Gly Leu Ala Val Phe 
1               5                   10                  15      


Ile Ser Asp Ile Arg Asn Cys Lys Ser Lys Glu Ala Glu Ile Lys Arg 
            20                  25                  30          


Ile Asn Lys Glu Leu Ala Asn Ile Arg Ser Lys Phe Lys Gly Asp Lys 
        35                  40                  45              


Ala Leu Asp Gly Tyr Lys Glu Pro Arg 
    50                  55          


<210> 2446
<211> 185
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<400> 2446
Glu Phe Phe Leu Pro Arg Leu Val Val Xaa Ala Ser Gly Xaa Pro Trp 
1               5                   10                  15      


Phe Ser Ser Gln Cys Phe Pro Ser Gly Ser Ser Glu Gly Lys Ser Lys 
            20                  25                  30          


Glu Ala Glu Ile Lys Arg Ile Asn Lys Glu Leu Ala Asn Ile Arg Ser 
        35                  40                  45              


Lys Phe Lys Gly Asp Lys Ala Leu Asp Gly Tyr Ser Lys Lys Lys Tyr 
    50                  55                  60                  


Val Cys Lys Leu Leu Phe Ile Phe Leu Leu Gly His Asp Ile Asp Phe 
65                  70                  75                  80  


Gly His Met Glu Ala Val Asn Leu Leu Ser Ser Asn Arg Tyr Xaa Glu 
                85                  90                  95      


Lys Gln Ile Gly Tyr Leu Phe Ile Ser Val Leu Val Asn Ser Asn Ser 
            100                 105                 110         


Glu Leu Ile Arg Leu Ile Asn Asn Ala Ile Lys Asn Asp Leu Ala Ser 
        115                 120                 125             


Arg Asn Pro Xaa Phe Met Gly Leu Ala Leu His Cys Ile Ala Ser Val 
    130                 135                 140                 


Gly Ser Arg Glu Met Ala Glu Ala Phe Ala Gly Glu Ile Pro Lys Val 
145                 150                 155                 160 


Leu Val Ala Gly Asp Xaa Met Asp Ser Val Lys Gln Ser Ala Ala Leu 
                165                 170                 175     


Cys Leu Leu Arg Leu Tyr Arg Xaa Ser 
            180                 185 


<210> 2447
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<400> 2447
Met Asp Ser Val Lys Gln Ser Ala Ala Leu Cys Leu Leu Arg Leu Tyr 
1               5                   10                  15      


Arg Xaa Ser Pro Asp Leu Val Pro Met Gly Asp Trp Xaa Ser Arg Val 
            20                  25                  30          


Val His Leu Leu Asn Asp Gln His Leu Gly Val Val Xaa Ala Ala Xaa 
        35                  40                  45              


Ser Leu Ile Xaa Xaa Leu Ala Gln Lys Asn Pro Glu Glu Phe Lys Xaa 
    50                  55                  60                  


Ser Val Ser Leu Ala Val Ser Arg Leu Ser Arg Ile Val Xaa Ser Ala 
65                  70                  75                  80  


Ser Xaa Asp Leu Gln Asp Tyr Xaa Tyr Tyr Phe Val Pro Ala Pro Trp 
                85                  90                  95      


Leu Ser Val Lys Leu Leu Arg Leu Leu Gln Cys Tyr Pro Pro Pro Asp 
            100                 105                 110         


Pro Ala Val Arg Gly Arg Leu Xaa Glu Cys Leu Glu Xaa 
        115                 120                 125 


<210> 2448
<211> 60
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 2448
Met Glu Ala Val Asn Leu Leu Ser Ser Asn Arg Tyr Xaa Glu Lys Gln 
1               5                   10                  15      


Ile Gly Tyr Leu Phe Ile Ser Val Leu Val Asn Ser Asn Ser Glu Leu 
            20                  25                  30          


Ile Arg Leu Ile Asn Asn Ala Ile Lys Asn Asp Leu Ala Ser Arg Asn 
        35                  40                  45              


Pro Xaa Phe Met Gly Leu Ala Leu His Cys Ile Ala 
    50                  55                  60  


<210> 2449
<211> 62
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 2449
Met Glu Ala Val Asn Leu Leu Ser Ser Asn Arg Tyr Xaa Glu Lys Gln 
1               5                   10                  15      


Ile Gly Tyr Leu Phe Ile Ser Val Leu Val Asn Ser Asn Ser Glu Leu 
            20                  25                  30          


Ile Arg Leu Ile Asn Asn Ala Ile Lys Asn Asp Leu Ala Ser Arg Asn 
        35                  40                  45              


Pro Xaa Phe Met Gly Leu Ala Leu His Cys Ile Ala Ser Val 
    50                  55                  60          


<210> 2450
<211> 90
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<400> 2450
Met Glu Ala Val Asn Leu Leu Ser Ser Asn Arg Tyr Xaa Glu Lys Gln 
1               5                   10                  15      


Ile Gly Tyr Leu Phe Ile Ser Val Leu Val Asn Ser Asn Ser Glu Leu 
            20                  25                  30          


Ile Arg Leu Ile Asn Asn Ala Ile Lys Asn Asp Leu Ala Ser Arg Asn 
        35                  40                  45              


Pro Xaa Phe Met Gly Leu Ala Leu His Cys Ile Ala Ser Val Gly Ser 
    50                  55                  60                  


Arg Glu Met Ala Glu Ala Phe Ala Gly Glu Ile Pro Lys Val Leu Val 
65                  70                  75                  80  


Ala Gly Asp Xaa Met Asp Ser Val Lys Gln 
                85                  90  


<210> 2451
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<400> 2451
Met Leu Val Gln Phe Phe Gln Arg Xaa Leu Asp Ser Leu Leu Leu Leu 
1               5                   10                  15      


Gly Lys Ser Lys Glu Ala Glu Ile Lys Arg Ile Asn Lys Glu Leu Ala 
            20                  25                  30          


Asn Ile Arg Ser Lys Phe Lys Gly Asp Lys Ala Leu Asp Gly Tyr Ser 
        35                  40                  45              


Lys Lys Lys Tyr Val Cys Lys Leu Leu Phe Ile Phe Leu Leu Gly His 
    50                  55                  60                  


Asp Ile Asp Phe Gly His Met Glu Ala Val Asn Leu Leu Ser Ser Asn 
65                  70                  75                  80  


Arg Tyr Xaa Glu Lys Gln Ile Gly Tyr Leu Phe Ile Ser Val Leu Val 
                85                  90                  95      


Asn Ser Asn Ser Glu Leu Ile Arg Leu Ile Asn Asn Ala Ile Lys Asn 
            100                 105                 110         


Asp Leu Ala Ser Arg Asn Pro Xaa Phe Met Gly Leu Ala Leu His Cys 
        115                 120                 125             


Ile Ala Ser Val Gly Ser Arg Glu Met Ala 
    130                 135             


<210> 2452
<211> 378
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<400> 2452
Met Pro Ala Val Ser Lys Gly Asp Gly Met Arg Gly Leu Ala Val Phe 
1               5                   10                  15      


Ile Ser Asp Ile Arg Asn Cys Lys Ser Lys Glu Ala Glu Ile Lys Arg 
            20                  25                  30          


Ile Asn Lys Glu Leu Ala Asn Ile Arg Ser Lys Phe Lys Gly Asp Lys 
        35                  40                  45              


Ala Leu Asp Gly Tyr Ser Lys Lys Lys Tyr Val Cys Lys Leu Leu Phe 
    50                  55                  60                  


Ile Phe Leu Leu Gly His Asp Ile Asp Phe Gly His Met Glu Ala Val 
65                  70                  75                  80  


Asn Leu Leu Ser Ser Asn Arg Tyr Xaa Glu Lys Gln Ile Gly Tyr Leu 
                85                  90                  95      


Phe Ile Ser Val Leu Val Asn Ser Asn Ser Glu Leu Ile Arg Leu Ile 
            100                 105                 110         


Asn Asn Ala Ile Lys Asn Asp Leu Ala Ser Arg Asn Pro Xaa Phe Met 
        115                 120                 125             


Gly Leu Ala Leu His Cys Ile Ala Ser Val Gly Ser Arg Glu Met Ala 
    130                 135                 140                 


Glu Ala Phe Ala Gly Glu Ile Pro Lys Val Leu Val Ala Gly Asp Xaa 
145                 150                 155                 160 


Met Asp Ser Val Lys Gln Ser Ala Ala Leu Cys Leu Leu Arg Leu Tyr 
                165                 170                 175     


Arg Xaa Ser Pro Asp Leu Val Pro Met Gly Asp Trp Xaa Ser Arg Val 
            180                 185                 190         


Val His Leu Leu Asn Asp Gln His Leu Gly Val Val Xaa Ala Ala Xaa 
        195                 200                 205             


Ser Leu Ile Xaa Xaa Leu Ala Gln Lys Asn Pro Glu Glu Phe Lys Xaa 
    210                 215                 220                 


Ser Val Ser Leu Ala Val Ser Arg Leu Ser Arg Ile Val Xaa Ser Ala 
225                 230                 235                 240 


Ser Xaa Asp Leu Gln Asp Tyr Xaa Tyr Tyr Phe Val Pro Ala Pro Trp 
                245                 250                 255     


Leu Ser Val Lys Leu Leu Arg Leu Leu Gln Cys Tyr Pro Pro Pro Asp 
            260                 265                 270         


Pro Ala Val Arg Gly Arg Leu Xaa Glu Cys Leu Glu Xaa Ile Leu Asn 
        275                 280                 285             


Lys Ala Gln Glu Pro Pro Lys Ser Lys Lys Val Gln His Ser Asn Ala 
    290                 295                 300                 


Lys Asn Ala Val Leu Phe Glu Ala Ile Ser Leu Ile Ile His His Asp 
305                 310                 315                 320 


Arg Cys Val Gly Cys Leu Cys Xaa Gly Ser Arg Cys Ala Gln Val Arg 
                325                 330                 335     


Lys Pro Phe Leu Arg Asp Tyr Val Asn Cys Ser Gln Arg Ser Phe Ser 
            340                 345                 350         


Pro Glu Asp Gly Arg Pro Gly Ser Cys Val Leu Cys Cys Leu Arg Leu 
        355                 360                 365             


Cys Arg Leu Ser Ser Trp Pro Ser Cys Arg 
    370                 375             


<210> 2453
<211> 656
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<400> 2453
Met Pro Ala Val Ser Lys Gly Asp Gly Met Arg Gly Leu Ala Val Phe 
1               5                   10                  15      


Ile Ser Asp Ile Arg Asn Cys Lys Ser Lys Glu Ala Glu Ile Lys Arg 
            20                  25                  30          


Ile Asn Lys Glu Leu Ala Asn Ile Arg Ser Lys Phe Lys Gly Asp Lys 
        35                  40                  45              


Ala Leu Asp Gly Tyr Ser Lys Lys Lys Tyr Val Cys Lys Leu Leu Phe 
    50                  55                  60                  


Ile Phe Leu Leu Gly His Asp Ile Asp Phe Gly His Met Glu Ala Val 
65                  70                  75                  80  


Asn Leu Leu Ser Ser Asn Arg Tyr Xaa Glu Lys Gln Ile Gly Tyr Leu 
                85                  90                  95      


Phe Ile Ser Val Leu Val Asn Ser Asn Ser Glu Leu Ile Arg Leu Ile 
            100                 105                 110         


Asn Asn Ala Ile Lys Asn Asp Leu Ala Ser Arg Asn Pro Xaa Phe Met 
        115                 120                 125             


Gly Leu Ala Leu His Cys Ile Ala Ser Val Gly Ser Arg Glu Met Ala 
    130                 135                 140                 


Glu Ala Phe Ala Gly Glu Ile Pro Lys Val Leu Val Ala Gly Asp Xaa 
145                 150                 155                 160 


Met Asp Ser Val Lys Gln Ser Ala Ala Leu Cys Leu Leu Arg Leu Tyr 
                165                 170                 175     


Arg Xaa Ser Pro Asp Leu Val Pro Met Gly Asp Trp Xaa Ser Arg Val 
            180                 185                 190         


Val His Leu Leu Asn Asp Gln His Leu Gly Val Val Xaa Ala Ala Xaa 
        195                 200                 205             


Ser Leu Ile Xaa Xaa Leu Ala Gln Lys Asn Pro Glu Glu Phe Lys Xaa 
    210                 215                 220                 


Ser Val Ser Leu Ala Val Ser Arg Leu Ser Arg Ile Val Xaa Ser Ala 
225                 230                 235                 240 


Ser Xaa Asp Leu Gln Asp Tyr Xaa Tyr Tyr Phe Val Pro Ala Pro Trp 
                245                 250                 255     


Leu Ser Val Lys Leu Leu Arg Leu Leu Gln Cys Tyr Pro Pro Pro Glu 
            260                 265                 270         


Asp Pro Ala Val Arg Gly Arg Leu Xaa Glu Cys Leu Glu Xaa Ile Leu 
        275                 280                 285             


Asn Lys Ala Gln Glu Pro Pro Lys Ser Lys Lys Val Gln His Ser Asn 
    290                 295                 300                 


Ala Lys Asn Ala Val Leu Phe Glu Ala Ile Ser Leu Ile Ile His His 
305                 310                 315                 320 


Asp Ser Glu Pro Asn Leu Leu Val Arg Ala Cys Asn Gln Leu Gly Gln 
                325                 330                 335     


Phe Leu Gln His Arg Glu Xaa Asn Leu Arg Tyr Leu Ala Leu Glu Ser 
            340                 345                 350         


Met Cys Xaa Leu Ala Ser Ser Glu Phe Ser His Glu Ala Val Lys Xaa 
        355                 360                 365             


His Ile Glu Xaa Val Ile Asn Ala Leu Lys Xaa Glu Arg Asp Val Ser 
    370                 375                 380                 


Val Arg Gln Arg Ala Val Asp Leu Leu Tyr Ala Met Cys Asp Arg Ser 
385                 390                 395                 400 


Asn Ala Pro Gln Ile Val Ala Glu Met Leu Ser Tyr Leu Glu Xaa Ala 
                405                 410                 415     


Asp Tyr Ser Ile Arg Glu Glu Ile Val Leu Lys Val Ala Ile Leu Ala 
            420                 425                 430         


Glu Lys Tyr Ala Val Asp Tyr Xaa Trp Tyr Val Asp Xaa Ile Leu Asn 
        435                 440                 445             


Leu Ile Arg Ile Ala Gly Asp Tyr Val Ser Glu Glu Val Trp Tyr Arg 
    450                 455                 460                 


Val Ile Gln Ile Val Ile Asn Arg Asp Asp Val Gln Gly Tyr Ala Ala 
465                 470                 475                 480 


Lys Xaa Val Phe Glu Ala Leu Gln Ala Pro Ala Cys His Glu Asn Leu 
                485                 490                 495     


Val Lys Val Gly Gly Tyr Ile Leu Gly Glu Phe Gly Asn Leu Ile Ala 
            500                 505                 510         


Gly Asp Pro Arg Ser Ser Pro Leu Ile Gln Phe His Leu Leu His Ser 
        515                 520                 525             


Lys Phe His Leu Cys Ser Val Pro Xaa Arg Ala Leu Leu Leu Ser Xaa 
    530                 535                 540                 


Tyr Ile Lys Phe Val Asn Leu Phe Pro Glu Val Lys Pro Xaa Ile Gln 
545                 550                 555                 560 


Asp Val Leu Arg Ser Asp Ser Gln Leu Arg Asn Ala Asp Val Glu Leu 
                565                 570                 575     


Gln Gln Arg Ala Val Glu Tyr Leu Arg Leu Ser Xaa Val Ala Ser Xaa 
            580                 585                 590         


Asp Ile Leu Ala Xaa Val Leu Glu Glu Met Pro Pro Phe Pro Glu Arg 
        595                 600                 605             


Glu Ser Ser Ile Leu Ala Lys Leu Lys Lys Lys Lys Gly Pro Ser Xaa 
    610                 615                 620                 


Val Xaa Asp Leu Glu Asp Xaa Lys Arg Asp Arg Ser Val Asp Val Asn 
625                 630                 635                 640 


Gly Gly Pro Glu Pro Ala Pro Ala Ser Xaa Ser Ala Val Val Cys Leu 
                645                 650                 655     


<210> 2454
<211> 939
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<400> 2454
Met Pro Ala Val Ser Lys Gly Asp Gly Met Arg Gly Leu Ala Val Phe 
1               5                   10                  15      


Ile Ser Asp Ile Arg Asn Cys Lys Ser Lys Glu Ala Glu Ile Lys Arg 
            20                  25                  30          


Ile Asn Lys Glu Leu Ala Asn Ile Arg Ser Lys Phe Lys Gly Asp Lys 
        35                  40                  45              


Ala Leu Asp Gly Tyr Ser Lys Lys Lys Tyr Val Cys Lys Leu Leu Phe 
    50                  55                  60                  


Ile Phe Leu Leu Gly His Asp Ile Asp Phe Gly His Met Glu Ala Val 
65                  70                  75                  80  


Asn Leu Leu Ser Ser Asn Arg Tyr Xaa Glu Lys Gln Ile Gly Tyr Leu 
                85                  90                  95      


Phe Ile Ser Val Leu Val Asn Ser Asn Ser Glu Leu Ile Arg Leu Ile 
            100                 105                 110         


Asn Asn Ala Ile Lys Asn Asp Leu Ala Ser Arg Asn Pro Xaa Phe Met 
        115                 120                 125             


Gly Leu Ala Leu His Cys Ile Ala Ser Val Gly Ser Arg Glu Met Ala 
    130                 135                 140                 


Glu Ala Phe Ala Gly Glu Ile Pro Lys Val Leu Val Ala Gly Asp Xaa 
145                 150                 155                 160 


Met Asp Ser Val Lys Gln Ser Ala Ala Leu Cys Leu Leu Arg Leu Tyr 
                165                 170                 175     


Arg Xaa Ser Pro Asp Leu Val Pro Met Gly Asp Trp Xaa Ser Arg Val 
            180                 185                 190         


Val His Leu Leu Asn Asp Gln His Leu Gly Val Val Xaa Ala Ala Xaa 
        195                 200                 205             


Ser Leu Ile Xaa Xaa Leu Ala Gln Lys Asn Pro Glu Glu Phe Lys Xaa 
    210                 215                 220                 


Ser Val Ser Leu Ala Val Ser Arg Leu Ser Arg Ile Val Xaa Ser Ala 
225                 230                 235                 240 


Ser Xaa Asp Leu Gln Asp Tyr Xaa Tyr Tyr Phe Val Pro Ala Pro Trp 
                245                 250                 255     


Leu Ser Val Lys Leu Leu Arg Leu Leu Gln Cys Tyr Pro Pro Pro Asp 
            260                 265                 270         


Pro Ala Val Arg Gly Arg Leu Xaa Glu Cys Leu Glu Xaa Ile Leu Asn 
        275                 280                 285             


Lys Ala Gln Glu Pro Pro Lys Ser Lys Lys Val Gln His Ser Asn Ala 
    290                 295                 300                 


Lys Asn Ala Val Leu Phe Glu Ala Ile Ser Leu Ile Ile His His Asp 
305                 310                 315                 320 


Ser Glu Pro Asn Leu Leu Val Arg Ala Cys Asn Gln Leu Gly Gln Phe 
                325                 330                 335     


Leu Gln His Arg Glu Xaa Asn Leu Arg Tyr Leu Ala Leu Glu Ser Met 
            340                 345                 350         


Cys Xaa Leu Ala Ser Ser Glu Phe Ser His Glu Ala Val Lys Xaa His 
        355                 360                 365             


Ile Glu Xaa Val Ile Asn Ala Leu Lys Xaa Glu Arg Asp Val Ser Val 
    370                 375                 380                 


Arg Gln Arg Ala Val Asp Leu Leu Tyr Ala Met Cys Asp Arg Ser Asn 
385                 390                 395                 400 


Ala Pro Gln Ile Val Ala Glu Met Leu Ser Tyr Leu Glu Xaa Ala Asp 
                405                 410                 415     


Tyr Ser Ile Arg Glu Glu Ile Val Leu Lys Val Ala Ile Leu Ala Glu 
            420                 425                 430         


Lys Tyr Ala Val Asp Tyr Xaa Trp Tyr Val Asp Xaa Ile Leu Asn Leu 
        435                 440                 445             


Ile Arg Ile Ala Gly Asp Tyr Val Ser Glu Glu Val Trp Tyr Arg Val 
    450                 455                 460                 


Ile Gln Ile Val Ile Asn Arg Asp Asp Val Gln Gly Tyr Ala Ala Lys 
465                 470                 475                 480 


Xaa Val Phe Glu Ala Leu Gln Ala Pro Ala Cys His Glu Asn Leu Val 
                485                 490                 495     


Lys Val Gly Gly Tyr Ile Leu Gly Glu Phe Gly Asn Leu Ile Ala Gly 
            500                 505                 510         


Asp Pro Arg Ser Ser Pro Leu Ile Gln Phe His Leu Leu His Ser Lys 
        515                 520                 525             


Phe His Leu Cys Ser Val Pro Xaa Arg Ala Leu Leu Leu Ser Xaa Tyr 
    530                 535                 540                 


Ile Lys Phe Val Asn Leu Phe Pro Glu Val Lys Pro Xaa Ile Gln Asp 
545                 550                 555                 560 


Val Leu Arg Ser Asp Ser Gln Leu Arg Asn Ala Asp Val Glu Leu Gln 
                565                 570                 575     


Gln Arg Ala Val Glu Tyr Leu Arg Leu Ser Xaa Val Ala Ser Xaa Asp 
            580                 585                 590         


Ile Leu Ala Xaa Val Leu Glu Glu Met Pro Pro Phe Pro Glu Arg Glu 
        595                 600                 605             


Ser Ser Ile Leu Ala Lys Leu Lys Lys Lys Lys Gly Pro Ser Xaa Val 
    610                 615                 620                 


Xaa Asp Leu Glu Asp Xaa Lys Arg Asp Arg Ser Val Asp Val Asn Gly 
625                 630                 635                 640 


Gly Pro Glu Pro Ala Pro Ala Ser Xaa Ser Ala Val Ser Xaa Pro Ser 
                645                 650                 655     


Pro Ser Ala Asp Leu Leu Gly Leu Gly Ala Ala Pro Pro Ala Pro Ala 
            660                 665                 670         


Gly Pro Pro Pro Ser Ser Gly Gly Ser Gly Leu Leu Val Asp Val Phe 
        675                 680                 685             


Ser Asp Ser Ala Ser Val Val Ala Pro Leu Ala Pro Gly Ser Glu Asp 
    690                 695                 700                 


Asn Phe Ala Arg Phe Val Cys Lys Asn Asn Gly Val Leu Phe Glu Asn 
705                 710                 715                 720 


Gln Leu Leu Gln Ile Gly Leu Lys Ser Glu Phe Arg Gln Asn Leu Gly 
                725                 730                 735     


Arg Met Phe Ile Phe Tyr Gly Asn Lys Xaa Ser Xaa Gln Phe Leu Asn 
            740                 745                 750         


Phe Xaa Pro Xaa Leu Ile Cys Ser Asp Asp Leu Gln Pro Asn Leu Asn 
        755                 760                 765             


Leu Gln Xaa Lys Pro Val Asp Pro Xaa Val Glu Gly Gly Ala Gln Val 
    770                 775                 780                 


Gln Gln Val Val Asn Ile Glu Cys Val Ser Asp Phe Xaa Glu Ala Pro 
785                 790                 795                 800 


Val Leu Asn Ile Gln Phe Arg Tyr Gly Gly Xaa Phe Gln Asn Val Ser 
                805                 810                 815     


Val Gln Leu Pro Ile Xaa Leu Asn Lys Phe Phe Gln Pro Xaa Glu Met 
            820                 825                 830         


Ala Ser Gln Asp Phe Phe Gln Arg Trp Lys Gln Leu Ser Asn Pro Gln 
        835                 840                 845             


Gln Glu Val Gln Asn Ile Phe Lys Ala Lys His Pro Met Asp Xaa Glu 
    850                 855                 860                 


Val Xaa Lys Ala Lys Ile Ile Gly Phe Gly Ser Ala Leu Leu Glu Glu 
865                 870                 875                 880 


Val Asp Pro Asn Pro Ala Asn Phe Val Gly Ala Gly Ile Ile His Xaa 
                885                 890                 895     


Lys Xaa Xaa Gln Ile Gly Cys Leu Leu Arg Leu Glu Pro Asn Leu Gln 
            900                 905                 910         


Ala Gln Met Tyr Arg Leu Xaa Leu Arg Xaa Ser Lys Glu Ala Val Ser 
        915                 920                 925             


Gln Arg Leu Cys Glu Leu Leu Ser Ala Gln Phe 
    930                 935                 


<210> 2455
<211> 940
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<400> 2455
Met Pro Ala Val Ser Lys Gly Asp Gly Met Arg Gly Leu Ala Val Phe 
1               5                   10                  15      


Ile Ser Asp Ile Arg Asn Cys Lys Ser Lys Glu Ala Glu Ile Lys Arg 
            20                  25                  30          


Ile Asn Lys Glu Leu Ala Asn Ile Arg Ser Lys Phe Lys Gly Asp Lys 
        35                  40                  45              


Ala Leu Asp Gly Tyr Ser Lys Lys Lys Tyr Val Cys Lys Leu Leu Phe 
    50                  55                  60                  


Ile Phe Leu Leu Gly His Asp Ile Asp Phe Gly His Met Glu Ala Val 
65                  70                  75                  80  


Asn Leu Leu Ser Ser Asn Arg Tyr Xaa Glu Lys Gln Ile Gly Tyr Leu 
                85                  90                  95      


Phe Ile Ser Val Leu Val Asn Ser Asn Ser Glu Leu Ile Arg Leu Ile 
            100                 105                 110         


Asn Asn Ala Ile Lys Asn Asp Leu Ala Ser Arg Asn Pro Xaa Phe Met 
        115                 120                 125             


Gly Leu Ala Leu His Cys Ile Ala Ser Val Gly Ser Arg Glu Met Ala 
    130                 135                 140                 


Glu Ala Phe Ala Gly Glu Ile Pro Lys Val Leu Val Ala Gly Asp Xaa 
145                 150                 155                 160 


Met Asp Ser Val Lys Gln Ser Ala Ala Leu Cys Leu Leu Arg Leu Tyr 
                165                 170                 175     


Arg Xaa Ser Pro Asp Leu Val Pro Met Gly Asp Trp Xaa Ser Arg Val 
            180                 185                 190         


Val His Leu Leu Asn Asp Gln His Leu Gly Val Val Xaa Ala Ala Xaa 
        195                 200                 205             


Ser Leu Ile Xaa Xaa Leu Ala Gln Lys Asn Pro Glu Glu Phe Lys Xaa 
    210                 215                 220                 


Ser Val Ser Leu Ala Val Ser Arg Leu Ser Arg Ile Val Xaa Ser Ala 
225                 230                 235                 240 


Ser Xaa Asp Leu Gln Asp Tyr Xaa Tyr Tyr Phe Val Pro Ala Pro Trp 
                245                 250                 255     


Leu Ser Val Lys Leu Leu Arg Leu Leu Gln Cys Tyr Pro Pro Pro Glu 
            260                 265                 270         


Asp Pro Ala Val Arg Gly Arg Leu Xaa Glu Cys Leu Glu Xaa Ile Leu 
        275                 280                 285             


Asn Lys Ala Gln Glu Pro Pro Lys Ser Lys Lys Val Gln His Ser Asn 
    290                 295                 300                 


Ala Lys Asn Ala Val Leu Phe Glu Ala Ile Ser Leu Ile Ile His His 
305                 310                 315                 320 


Asp Ser Glu Pro Asn Leu Leu Val Arg Ala Cys Asn Gln Leu Gly Gln 
                325                 330                 335     


Phe Leu Gln His Arg Glu Xaa Asn Leu Arg Tyr Leu Ala Leu Glu Ser 
            340                 345                 350         


Met Cys Xaa Leu Ala Ser Ser Glu Phe Ser His Glu Ala Val Lys Xaa 
        355                 360                 365             


His Ile Glu Xaa Val Ile Asn Ala Leu Lys Xaa Glu Arg Asp Val Ser 
    370                 375                 380                 


Val Arg Gln Arg Ala Val Asp Leu Leu Tyr Ala Met Cys Asp Arg Ser 
385                 390                 395                 400 


Asn Ala Pro Gln Ile Val Ala Glu Met Leu Ser Tyr Leu Glu Xaa Ala 
                405                 410                 415     


Asp Tyr Ser Ile Arg Glu Glu Ile Val Leu Lys Val Ala Ile Leu Ala 
            420                 425                 430         


Glu Lys Tyr Ala Val Asp Tyr Xaa Trp Tyr Val Asp Xaa Ile Leu Asn 
        435                 440                 445             


Leu Ile Arg Ile Ala Gly Asp Tyr Val Ser Glu Glu Val Trp Tyr Arg 
    450                 455                 460                 


Val Ile Gln Ile Val Ile Asn Arg Asp Asp Val Gln Gly Tyr Ala Ala 
465                 470                 475                 480 


Lys Xaa Val Phe Glu Ala Leu Gln Ala Pro Ala Cys His Glu Asn Leu 
                485                 490                 495     


Val Lys Val Gly Gly Tyr Ile Leu Gly Glu Phe Gly Asn Leu Ile Ala 
            500                 505                 510         


Gly Asp Pro Arg Ser Ser Pro Leu Ile Gln Phe His Leu Leu His Ser 
        515                 520                 525             


Lys Phe His Leu Cys Ser Val Pro Xaa Arg Ala Leu Leu Leu Ser Xaa 
    530                 535                 540                 


Tyr Ile Lys Phe Val Asn Leu Phe Pro Glu Val Lys Pro Xaa Ile Gln 
545                 550                 555                 560 


Asp Val Leu Arg Ser Asp Ser Gln Leu Arg Asn Ala Asp Val Glu Leu 
                565                 570                 575     


Gln Gln Arg Ala Val Glu Tyr Leu Arg Leu Ser Xaa Val Ala Ser Xaa 
            580                 585                 590         


Asp Ile Leu Ala Xaa Val Leu Glu Glu Met Pro Pro Phe Pro Glu Arg 
        595                 600                 605             


Glu Ser Ser Ile Leu Ala Lys Leu Lys Lys Lys Lys Gly Pro Ser Xaa 
    610                 615                 620                 


Val Xaa Asp Leu Glu Asp Xaa Lys Arg Asp Arg Ser Val Asp Val Asn 
625                 630                 635                 640 


Gly Gly Pro Glu Pro Ala Pro Ala Ser Xaa Ser Ala Val Ser Xaa Pro 
                645                 650                 655     


Ser Pro Ser Ala Asp Leu Leu Gly Leu Gly Ala Ala Pro Pro Ala Pro 
            660                 665                 670         


Ala Gly Pro Pro Pro Ser Ser Gly Gly Ser Gly Leu Leu Val Asp Val 
        675                 680                 685             


Phe Ser Asp Ser Ala Ser Val Val Ala Pro Leu Ala Pro Gly Ser Glu 
    690                 695                 700                 


Asp Asn Phe Ala Arg Phe Val Cys Lys Asn Asn Gly Val Leu Phe Glu 
705                 710                 715                 720 


Asn Gln Leu Leu Gln Ile Gly Leu Lys Ser Glu Phe Arg Gln Asn Leu 
                725                 730                 735     


Gly Arg Met Phe Ile Phe Tyr Gly Asn Lys Xaa Ser Xaa Gln Phe Leu 
            740                 745                 750         


Asn Phe Xaa Pro Xaa Leu Ile Cys Ser Asp Asp Leu Gln Pro Asn Leu 
        755                 760                 765             


Asn Leu Gln Xaa Lys Pro Val Asp Pro Xaa Val Glu Gly Gly Ala Gln 
    770                 775                 780                 


Val Gln Gln Val Val Asn Ile Glu Cys Val Ser Asp Phe Xaa Glu Ala 
785                 790                 795                 800 


Pro Val Leu Asn Ile Gln Phe Arg Tyr Gly Gly Xaa Phe Gln Asn Val 
                805                 810                 815     


Ser Val Gln Leu Pro Ile Xaa Leu Asn Lys Phe Phe Gln Pro Xaa Glu 
            820                 825                 830         


Met Ala Ser Gln Asp Phe Phe Gln Arg Trp Lys Gln Leu Ser Asn Pro 
        835                 840                 845             


Gln Gln Glu Val Gln Asn Ile Phe Lys Ala Lys His Pro Met Asp Xaa 
    850                 855                 860                 


Glu Val Xaa Lys Ala Lys Ile Ile Gly Phe Gly Ser Ala Leu Leu Glu 
865                 870                 875                 880 


Glu Val Asp Pro Asn Pro Ala Asn Phe Val Gly Ala Gly Ile Ile His 
                885                 890                 895     


Xaa Lys Xaa Xaa Gln Ile Gly Cys Leu Leu Arg Leu Glu Pro Asn Leu 
            900                 905                 910         


Gln Ala Gln Met Tyr Arg Leu Xaa Leu Arg Xaa Ser Lys Glu Ala Val 
        915                 920                 925             


Ser Gln Arg Leu Cys Glu Leu Leu Ser Ala Gln Phe 
    930                 935                 940 


<210> 2456
<211> 185
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<400> 2456
Val Arg Val Trp Pro Arg Arg Ile Glu Glu Ile Ala Cys Lys Ser Lys 
1               5                   10                  15      


Glu Ala Glu Ile Lys Arg Ile Asn Lys Glu Leu Ala Asn Ile Arg Ser 
            20                  25                  30          


Lys Phe Lys Gly Asp Lys Ala Leu Asp Gly Tyr Ser Lys Lys Lys Tyr 
        35                  40                  45              


Val Cys Lys Leu Leu Phe Ile Phe Leu Leu Gly His Asp Ile Asp Phe 
    50                  55                  60                  


Gly His Met Glu Ala Val Asn Leu Leu Ser Ser Asn Arg Tyr Xaa Glu 
65                  70                  75                  80  


Lys Gln Ile Gly Tyr Leu Phe Ile Ser Val Leu Val Asn Ser Asn Ser 
                85                  90                  95      


Glu Leu Ile Arg Leu Ile Asn Asn Ala Ile Lys Asn Asp Leu Ala Ser 
            100                 105                 110         


Arg Asn Pro Xaa Phe Met Gly Leu Ala Leu His Cys Ile Ala Ser Val 
        115                 120                 125             


Gly Ser Arg Glu Met Ala Glu Ala Phe Ala Gly Glu Ile Pro Lys Val 
    130                 135                 140                 


Leu Val Ala Gly Asp Xaa Met Asp Ser Val Lys Gln Ser Ala Ala Leu 
145                 150                 155                 160 


Cys Leu Leu Arg Leu Tyr Arg Xaa Ser Pro Asp Leu Val Pro Met Gly 
                165                 170                 175     


Asp Trp Xaa Ser Arg Val Val His Leu 
            180                 185 


<210> 2457
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 2457
Asp Leu Ile Glu Pro Xaa Leu Leu Asp Glu Leu Ile Cys His Ile Gly 
1               5                   10                  15      


Ser Leu Ala Ser Val Tyr His Lys Pro Pro Asn Ala Phe Val Glu Gly 
            20                  25                  30          


Ser His Gly Ile His Arg Lys His Leu Pro Ile His His Gly Ser Xaa 
        35                  40                  45              


Asp Ala Gly Asp Ser Pro Val Gly Xaa Xaa Xaa Ala Xaa Asn Leu Glu 
    50                  55                  60                  


Gln Pro Gln Val Ile Pro Ser Gln Gly Asp Leu Leu Gly Asp Leu Leu 
65                  70                  75                  80  


Asn Leu Asp Leu Gly Pro Pro Val Asn Val Pro Gln Val Ser Ser Met 
                85                  90                  95      


Gln Met Gly Ala Val Asp Leu Leu Gly Gly Gly Leu Asp Ser Leu Pro 
            100                 105                 110         


Gln Lys Leu Phe Xaa Val Gln Phe Ser Ser Ala Tyr Ser Glu Ile Glu 
        115                 120                 125             


Arg Tyr Pro Arg Asn Gln Asp Glu Lys Lys Leu Lys Pro Leu Phe Leu 
    130                 135                 140                 


Leu Trp Ile Arg Met Trp Leu Asn Ile Tyr Ser Leu Arg Glu Ser Arg 
145                 150                 155                 160 


Phe Leu Phe Arg Glu His His Lys Glu Asp Leu Asn Leu Pro Val Trp 
                165                 170                 175     


Lys Lys Met Ser Phe 
            180     


<210> 2458
<211> 63
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<400> 2458
Met Xaa Asp Ser Lys Tyr Phe Xaa Xaa Asn Lys Lys Gly Glu Ile Phe 
1               5                   10                  15      


Glu Leu Lys Ala Glu Leu Asn Asn Glu Lys Lys Glu Lys Arg Lys Glu 
            20                  25                  30          


Ala Val Lys Lys Val Ile Ala Ala Met Xaa Val Gly Lys Asp Val Arg 
        35                  40                  45              


Cys Cys Ser Ser Glu Val Asn Phe Cys Tyr Phe Ser Phe Val Cys 
    50                  55                  60              


<210> 2459
<211> 80
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<400> 2459
Met Xaa Asp Ser Lys Tyr Phe Xaa Xaa Asn Lys Lys Gly Glu Ile Phe 
1               5                   10                  15      


Glu Leu Lys Ala Glu Leu Asn Asn Glu Lys Lys Glu Lys Arg Lys Glu 
            20                  25                  30          


Ala Val Lys Lys Val Ile Ala Ala Met Xaa Val Gly Lys Asp Val Ser 
        35                  40                  45              


Ser Leu Phe Pro Asp Val Val Asn Cys Met Gln Xaa Asp Asn Leu Glu 
    50                  55                  60                  


Leu Lys Lys Leu Val Tyr Leu Tyr Leu Met Asn Tyr Ala Lys Ser Gln 
65                  70                  75                  80  


<210> 2460
<211> 132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<400> 2460
Met Xaa Asp Ser Lys Tyr Phe Xaa Xaa Asn Lys Lys Gly Glu Ile Phe 
1               5                   10                  15      


Glu Leu Lys Ala Glu Leu Asn Asn Glu Lys Lys Glu Lys Arg Lys Glu 
            20                  25                  30          


Ala Val Lys Lys Val Ile Ala Ala Met Xaa Val Gly Lys Asp Val Ser 
        35                  40                  45              


Ser Leu Phe Pro Asp Val Val Asn Cys Met Gln Xaa Asp Asn Leu Glu 
    50                  55                  60                  


Leu Lys Lys Leu Val Tyr Leu Tyr Leu Met Asn Tyr Ala Lys Ser Gln 
65                  70                  75                  80  


Pro Asp Met Ala Ile Met Ala Val Asn Ser Phe Val Lys Asp Cys Glu 
                85                  90                  95      


Asp Pro Asn Pro Leu Ile Arg Ala Leu Ala Val Arg Xaa Met Gly Cys 
            100                 105                 110         


Ile Arg Val Asp Lys Ile Xaa Glu Tyr Leu Cys Glu Pro Leu Arg Lys 
        115                 120                 125             


Cys Leu Lys Asp 
    130         


<210> 2461
<211> 151
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<400> 2461
Met Xaa Asp Ser Lys Tyr Phe Xaa Xaa Asn Lys Lys Gly Glu Ile Phe 
1               5                   10                  15      


Glu Leu Lys Ala Glu Leu Asn Asn Glu Lys Lys Glu Lys Arg Lys Glu 
            20                  25                  30          


Ala Val Lys Lys Val Ile Ala Ala Met Xaa Val Gly Lys Asp Val Ser 
        35                  40                  45              


Ser Leu Phe Pro Asp Val Val Asn Cys Met Gln Xaa Asp Asn Leu Glu 
    50                  55                  60                  


Leu Lys Lys Leu Val Tyr Leu Tyr Leu Met Asn Tyr Ala Lys Ser Gln 
65                  70                  75                  80  


Pro Asp Met Ala Ile Met Ala Val Asn Ser Phe Val Lys Asp Cys Glu 
                85                  90                  95      


Asp Pro Asn Pro Leu Ile Arg Ala Leu Ala Val Arg Xaa Met Gly Cys 
            100                 105                 110         


Ile Arg Val Asp Lys Ile Xaa Glu Tyr Leu Cys Glu Pro Leu Arg Lys 
        115                 120                 125             


Cys Leu Lys Asp Glu Asp Pro Tyr Val Arg Lys Xaa Ala Ala Val Cys 
    130                 135                 140                 


Val Ala Lys Leu His Asp Ile 
145                 150     


<210> 2462
<211> 663
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<400> 2462
Met Xaa Asp Ser Lys Tyr Phe Xaa Xaa Asn Lys Lys Gly Glu Ile Phe 
1               5                   10                  15      


Glu Leu Lys Ala Glu Leu Asn Asn Glu Lys Lys Glu Lys Arg Lys Glu 
            20                  25                  30          


Ala Val Lys Lys Val Ile Ala Ala Met Xaa Val Gly Lys Asp Val Ser 
        35                  40                  45              


Ser Leu Phe Pro Asp Val Val Asn Cys Met Gln Xaa Asp Asn Leu Glu 
    50                  55                  60                  


Leu Lys Lys Leu Val Tyr Leu Tyr Leu Met Asn Tyr Ala Lys Ser Gln 
65                  70                  75                  80  


Pro Asp Met Ala Ile Met Ala Val Asn Ser Phe Val Lys Asp Cys Glu 
                85                  90                  95      


Asp Pro Asn Pro Leu Ile Arg Ala Leu Ala Val Arg Xaa Met Gly Cys 
            100                 105                 110         


Ile Arg Val Asp Lys Ile Xaa Glu Tyr Leu Cys Glu Pro Leu Arg Lys 
        115                 120                 125             


Cys Leu Lys Asp Glu Asp Pro Tyr Val Arg Lys Xaa Ala Ala Val Cys 
    130                 135                 140                 


Val Ala Lys Leu His Asp Ile Asn Ala Gln Met Val Glu Asp Gln Gly 
145                 150                 155                 160 


Phe Leu Asp Ser Leu Arg Asp Leu Ile Ala Asp Ser Asn Pro Met Val 
                165                 170                 175     


Val Ala Asn Ala Val Ala Ala Leu Ser Glu Ile Ser Glu Ser His Pro 
            180                 185                 190         


Asn Ser Asn Leu Leu Asp Leu Asn Pro Gln Asn Ile Asn Lys Leu Leu 
        195                 200                 205             


Xaa Ala Leu Asn Glu Cys Xaa Glu Trp Gly Gln Ile Phe Ile Leu Asp 
    210                 215                 220                 


Cys Leu Ser Asn Tyr Asn Pro Lys Asp Asp Arg Glu Ala Gln Ser Ile 
225                 230                 235                 240 


Cys Glu Arg Val Xaa Pro Arg Leu Ser His Ala Asn Ser Ala Val Val 
                245                 250                 255     


Leu Ser Ala Val Lys Val Leu Met Lys Phe Leu Glu Leu Leu Pro Lys 
            260                 265                 270         


Asp Ser Asp Tyr Tyr Asn Met Leu Leu Lys Lys Leu Ala Pro Pro Leu 
        275                 280                 285             


Val Xaa Leu Leu Ser Gly Glu Pro Glu Val Gln Tyr Val Ala Leu Arg 
    290                 295                 300                 


Asn Ile Asn Leu Ile Val Gln Lys Arg Pro Glu Ile Leu Lys Gln Glu 
305                 310                 315                 320 


Ile Lys Val Phe Phe Val Lys Tyr Asn Asp Pro Ile Tyr Val Lys Leu 
                325                 330                 335     


Glu Lys Leu Asp Ile Met Ile Arg Leu Ala Ser Gln Ala Asn Ile Ala 
            340                 345                 350         


Gln Val Leu Ala Glu Leu Lys Glu Tyr Ala Xaa Glu Val Asp Val Asp 
        355                 360                 365             


Phe Val Arg Lys Ala Val Arg Ala Ile Gly Arg Cys Ala Ile Lys Val 
    370                 375                 380                 


Glu Gln Ser Ala Glu Arg Cys Val Ser Xaa Leu Leu Asp Leu Ile Gln 
385                 390                 395                 400 


Xaa Lys Val Asn Tyr Val Val Gln Glu Ala Ile Val Val Ile Arg Asp 
                405                 410                 415     


Ile Phe Arg Lys Tyr Pro Asn Lys Tyr Glu Ser Ile Ile Ala Xaa Leu 
            420                 425                 430         


Cys Glu Asn Leu Asp Ser Leu Asp Glu Pro Asp Ala Arg Ala Ala Met 
        435                 440                 445             


Ile Trp Ile Val Gly Glu Tyr Ala Glu Arg Ile Asp Asn Ala Asp Glu 
    450                 455                 460                 


Leu Leu Glu Ser Phe Leu Glu Gly Phe His Asp Glu Ser Xaa Gln Val 
465                 470                 475                 480 


Gln Leu Xaa Leu Leu Xaa Ala Ile Val Lys Leu Phe Leu Lys Lys Pro 
                485                 490                 495     


Ser Glu Xaa Gln Glu Leu Val Gln Gln Val Leu Ser Leu Ala Xaa Gln 
            500                 505                 510         


Asp Ser Asp Asn Pro Asp Leu Arg Asp Arg Gly Tyr Ile Tyr Trp Arg 
        515                 520                 525             


Leu Leu Ser Xaa Asp Pro Val Xaa Ala Lys Glu Val Val Leu Ser Glu 
    530                 535                 540                 


Lys Pro Leu Ile Ser Glu Glu Xaa Asp Leu Ile Glu Pro Xaa Leu Leu 
545                 550                 555                 560 


Asp Glu Leu Ile Cys His Ile Gly Ser Leu Ala Ser Val Tyr His Lys 
                565                 570                 575     


Pro Pro Asn Ala Phe Val Glu Gly Ser His Gly Ile His Arg Lys His 
            580                 585                 590         


Leu Pro Ile His His Gly Ser Xaa Asp Ala Gly Asp Ser Pro Val Gly 
        595                 600                 605             


Xaa Xaa Xaa Ala Xaa Asn Leu Glu Gln Pro Gln Val Ile Pro Ser Gln 
    610                 615                 620                 


Gly Asp Leu Leu Gly Asp Leu Leu Asn Leu Asp Leu Gly Pro Pro Val 
625                 630                 635                 640 


Asn Val Pro Gln Val Ser Ser Met Gln Met Gly Ala Val Asp Leu Leu 
                645                 650                 655     


Gly Gly Gly Leu Asp Ser Leu 
            660             


<210> 2463
<211> 677
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<400> 2463
Met Xaa Asp Ser Lys Tyr Phe Xaa Xaa Asn Lys Lys Gly Glu Ile Phe 
1               5                   10                  15      


Glu Leu Lys Ala Glu Leu Asn Asn Glu Lys Lys Glu Lys Arg Lys Glu 
            20                  25                  30          


Ala Val Lys Lys Val Ile Ala Ala Met Xaa Val Gly Lys Asp Val Ser 
        35                  40                  45              


Ser Leu Phe Pro Asp Val Val Asn Cys Met Gln Xaa Asp Asn Leu Glu 
    50                  55                  60                  


Leu Lys Lys Leu Val Tyr Leu Tyr Leu Met Asn Tyr Ala Lys Ser Gln 
65                  70                  75                  80  


Pro Asp Met Ala Ile Met Ala Val Asn Ser Phe Val Lys Asp Cys Glu 
                85                  90                  95      


Asp Pro Asn Pro Leu Ile Arg Ala Leu Ala Val Arg Xaa Met Gly Cys 
            100                 105                 110         


Ile Arg Val Asp Lys Ile Xaa Glu Tyr Leu Cys Glu Pro Leu Arg Lys 
        115                 120                 125             


Cys Leu Lys Asp Glu Asp Pro Tyr Val Arg Lys Xaa Ala Ala Val Cys 
    130                 135                 140                 


Val Ala Lys Leu His Asp Ile Asn Ala Gln Met Val Glu Asp Gln Gly 
145                 150                 155                 160 


Phe Leu Asp Ser Leu Arg Asp Leu Ile Ala Asp Ser Asn Pro Met Val 
                165                 170                 175     


Val Ala Asn Ala Val Ala Ala Leu Ser Glu Ile Ser Glu Ser His Pro 
            180                 185                 190         


Asn Ser Asn Leu Leu Asp Leu Asn Pro Gln Asn Ile Asn Lys Leu Leu 
        195                 200                 205             


Xaa Ala Leu Asn Glu Cys Xaa Glu Trp Gly Gln Ile Phe Ile Leu Asp 
    210                 215                 220                 


Cys Leu Ser Asn Tyr Asn Pro Lys Asp Asp Arg Glu Ala Gln Ser Ile 
225                 230                 235                 240 


Cys Glu Arg Val Xaa Pro Arg Leu Ser His Ala Asn Ser Ala Val Val 
                245                 250                 255     


Leu Ser Ala Val Lys Val Leu Met Lys Phe Leu Glu Leu Leu Pro Lys 
            260                 265                 270         


Asp Ser Asp Tyr Tyr Asn Met Leu Leu Lys Lys Leu Ala Pro Pro Leu 
        275                 280                 285             


Val Xaa Leu Leu Ser Gly Glu Pro Glu Val Gln Tyr Val Ala Leu Arg 
    290                 295                 300                 


Asn Ile Asn Leu Ile Val Gln Lys Arg Pro Glu Ile Leu Lys Gln Glu 
305                 310                 315                 320 


Ile Lys Val Phe Phe Val Lys Tyr Asn Asp Pro Ile Tyr Val Lys Leu 
                325                 330                 335     


Glu Lys Leu Asp Ile Met Ile Arg Leu Ala Ser Gln Ala Asn Ile Ala 
            340                 345                 350         


Gln Val Leu Ala Glu Leu Lys Glu Tyr Ala Xaa Glu Val Asp Val Asp 
        355                 360                 365             


Phe Val Arg Lys Ala Val Arg Ala Ile Gly Arg Cys Ala Ile Lys Val 
    370                 375                 380                 


Glu Gln Ser Ala Glu Arg Cys Val Ser Xaa Leu Leu Asp Leu Ile Gln 
385                 390                 395                 400 


Xaa Lys Val Asn Tyr Val Val Gln Glu Ala Ile Val Val Ile Arg Asp 
                405                 410                 415     


Ile Phe Arg Lys Tyr Pro Asn Lys Tyr Glu Ser Ile Ile Ala Xaa Leu 
            420                 425                 430         


Cys Glu Asn Leu Asp Ser Leu Asp Glu Pro Asp Ala Arg Ala Ala Met 
        435                 440                 445             


Ile Trp Ile Val Gly Glu Tyr Ala Glu Arg Ile Asp Asn Ala Asp Glu 
    450                 455                 460                 


Leu Leu Glu Ser Phe Leu Glu Gly Phe His Asp Glu Ser Xaa Gln Val 
465                 470                 475                 480 


Gln Leu Xaa Leu Leu Xaa Ala Ile Val Lys Leu Phe Leu Lys Lys Pro 
                485                 490                 495     


Ser Glu Xaa Gln Glu Leu Val Gln Gln Val Leu Ser Leu Ala Xaa Gln 
            500                 505                 510         


Asp Ser Asp Asn Pro Asp Leu Arg Asp Arg Gly Tyr Ile Tyr Trp Arg 
        515                 520                 525             


Leu Leu Ser Xaa Asp Pro Val Xaa Ala Lys Glu Val Val Leu Ser Glu 
    530                 535                 540                 


Lys Pro Leu Ile Ser Glu Glu Xaa Asp Leu Ile Glu Pro Xaa Leu Leu 
545                 550                 555                 560 


Asp Glu Leu Ile Cys His Ile Gly Ser Leu Ala Ser Val Tyr His Lys 
                565                 570                 575     


Pro Pro Asn Ala Phe Val Glu Gly Ser His Gly Ile His Arg Lys His 
            580                 585                 590         


Leu Pro Ile His His Gly Ser Xaa Asp Ala Gly Asp Ser Pro Val Gly 
        595                 600                 605             


Xaa Xaa Xaa Ala Xaa Asn Leu Glu Gln Pro Gln Val Ile Pro Ser Gln 
    610                 615                 620                 


Gly Asp Leu Leu Gly Asp Leu Leu Asn Leu Asp Leu Gly Pro Pro Val 
625                 630                 635                 640 


Asn Val Pro Gln Val Ser Ser Met Gln Met Gly Ala Val Asp Leu Leu 
                645                 650                 655     


Gly Gly Gly Leu Asp Ser Leu Leu Gly Ser Asp Leu Gly Gly Gly Ile 
            660                 665                 670         


Gly Gly Ser Pro Ala 
        675         


<210> 2464
<211> 937
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<400> 2464
Met Xaa Asp Ser Lys Tyr Phe Xaa Xaa Asn Lys Lys Gly Glu Ile Phe 
1               5                   10                  15      


Glu Leu Lys Ala Glu Leu Asn Asn Glu Lys Lys Glu Lys Arg Lys Glu 
            20                  25                  30          


Ala Val Lys Lys Val Ile Ala Ala Met Xaa Val Gly Lys Asp Val Ser 
        35                  40                  45              


Ser Leu Phe Pro Asp Val Val Asn Cys Met Gln Xaa Asp Asn Leu Glu 
    50                  55                  60                  


Leu Lys Lys Leu Val Tyr Leu Tyr Leu Met Asn Tyr Ala Lys Ser Gln 
65                  70                  75                  80  


Pro Asp Met Ala Ile Met Ala Val Asn Ser Phe Val Lys Asp Cys Glu 
                85                  90                  95      


Asp Pro Asn Pro Leu Ile Arg Ala Leu Ala Val Arg Xaa Met Gly Cys 
            100                 105                 110         


Ile Arg Val Asp Lys Ile Xaa Glu Tyr Leu Cys Glu Pro Leu Arg Lys 
        115                 120                 125             


Cys Leu Lys Asp Glu Asp Pro Tyr Val Arg Lys Xaa Ala Ala Val Cys 
    130                 135                 140                 


Val Ala Lys Leu His Asp Ile Asn Ala Gln Met Val Glu Asp Gln Gly 
145                 150                 155                 160 


Phe Leu Asp Ser Leu Arg Asp Leu Ile Ala Asp Ser Asn Pro Met Val 
                165                 170                 175     


Val Ala Asn Ala Val Ala Ala Leu Ser Glu Ile Ser Glu Ser His Pro 
            180                 185                 190         


Asn Ser Asn Leu Leu Asp Leu Asn Pro Gln Asn Ile Asn Lys Leu Leu 
        195                 200                 205             


Xaa Ala Leu Asn Glu Cys Xaa Glu Trp Gly Gln Ile Phe Ile Leu Asp 
    210                 215                 220                 


Cys Leu Ser Asn Tyr Asn Pro Lys Asp Asp Arg Glu Ala Gln Ser Ile 
225                 230                 235                 240 


Cys Glu Arg Val Xaa Pro Arg Leu Ser His Ala Asn Ser Ala Val Val 
                245                 250                 255     


Leu Ser Ala Val Lys Val Leu Met Lys Phe Leu Glu Leu Leu Pro Lys 
            260                 265                 270         


Asp Ser Asp Tyr Tyr Asn Met Leu Leu Lys Lys Leu Ala Pro Pro Leu 
        275                 280                 285             


Val Xaa Leu Leu Ser Gly Glu Pro Glu Val Gln Tyr Val Ala Leu Arg 
    290                 295                 300                 


Asn Ile Asn Leu Ile Val Gln Lys Arg Pro Glu Ile Leu Lys Gln Glu 
305                 310                 315                 320 


Ile Lys Val Phe Phe Val Lys Tyr Asn Asp Pro Ile Tyr Val Lys Leu 
                325                 330                 335     


Glu Lys Leu Asp Ile Met Ile Arg Leu Ala Ser Gln Ala Asn Ile Ala 
            340                 345                 350         


Gln Val Leu Ala Glu Leu Lys Glu Tyr Ala Xaa Glu Val Asp Val Asp 
        355                 360                 365             


Phe Val Arg Lys Ala Val Arg Ala Ile Gly Arg Cys Ala Ile Lys Val 
    370                 375                 380                 


Glu Gln Ser Ala Glu Arg Cys Val Ser Xaa Leu Leu Asp Leu Ile Gln 
385                 390                 395                 400 


Xaa Lys Val Asn Tyr Val Val Gln Glu Ala Ile Val Val Ile Arg Asp 
                405                 410                 415     


Ile Phe Arg Lys Tyr Pro Asn Lys Tyr Glu Ser Ile Ile Ala Xaa Leu 
            420                 425                 430         


Cys Glu Asn Leu Asp Ser Leu Asp Glu Pro Asp Ala Arg Ala Ala Met 
        435                 440                 445             


Ile Trp Ile Val Gly Glu Tyr Ala Glu Arg Ile Asp Asn Ala Asp Glu 
    450                 455                 460                 


Leu Leu Glu Ser Phe Leu Glu Gly Phe His Asp Glu Ser Xaa Gln Val 
465                 470                 475                 480 


Gln Leu Xaa Leu Leu Xaa Ala Ile Val Lys Leu Phe Leu Lys Lys Pro 
                485                 490                 495     


Ser Glu Xaa Gln Glu Leu Val Gln Gln Val Leu Ser Leu Ala Xaa Gln 
            500                 505                 510         


Asp Ser Asp Asn Pro Asp Leu Arg Asp Arg Gly Tyr Ile Tyr Trp Arg 
        515                 520                 525             


Leu Leu Ser Xaa Asp Pro Val Xaa Ala Lys Glu Val Val Leu Ser Glu 
    530                 535                 540                 


Lys Pro Leu Ile Ser Glu Glu Xaa Asp Leu Ile Glu Pro Xaa Leu Leu 
545                 550                 555                 560 


Asp Glu Leu Ile Cys His Ile Gly Ser Leu Ala Ser Val Tyr His Lys 
                565                 570                 575     


Pro Pro Asn Ala Phe Val Glu Gly Ser His Gly Ile His Arg Lys His 
            580                 585                 590         


Leu Pro Ile His His Gly Ser Xaa Asp Ala Gly Asp Ser Pro Val Gly 
        595                 600                 605             


Xaa Xaa Xaa Ala Xaa Asn Leu Glu Gln Pro Gln Val Ile Pro Ser Gln 
    610                 615                 620                 


Gly Asp Leu Leu Gly Asp Leu Leu Asn Leu Asp Leu Gly Pro Pro Val 
625                 630                 635                 640 


Asn Val Pro Gln Val Ser Ser Met Gln Met Gly Ala Val Asp Leu Leu 
                645                 650                 655     


Gly Gly Gly Leu Asp Ser Leu Val Gly Gln Ser Phe Ile Pro Ser Ser 
            660                 665                 670         


Val Pro Ala Xaa Phe Ala Pro Ser Pro Xaa Pro Ala Val Val Ser Ser 
        675                 680                 685             


Gly Leu Asn Asp Leu Phe Glu Leu Ser Xaa Gly Ile Gly Met Ala Pro 
    690                 695                 700                 


Gly Gly Tyr Val Ala Pro Lys Ala Val Trp Leu Pro Ala Val Lys Ala 
705                 710                 715                 720 


Lys Gly Leu Glu Ile Ser Gly Xaa Phe Xaa His Arg Gln Gly His Ile 
                725                 730                 735     


Tyr Met Glu Met Asn Phe Xaa Asn Lys Ala Leu Gln His Met Xaa Asp 
            740                 745                 750         


Phe Ala Ile Gln Phe Asn Lys Asn Ser Phe Gly Val Ile Pro Ser Xaa 
        755                 760                 765             


Pro Leu Ala Ile His Xaa Pro Leu Met Pro Asn Gln Ser Ile Asp Val 
    770                 775                 780                 


Ser Leu Pro Leu Asn Xaa Leu Gly Pro Val Met Lys Met Glu Pro Leu 
785                 790                 795                 800 


Asn Asn Leu Gln Val Ala Val Lys Asn Asn Ile Asp Val Phe Tyr Phe 
                805                 810                 815     


Ser Cys Leu Ile Pro Leu Asn Val Leu Phe Val Glu Asp Gly Lys Met 
            820                 825                 830         


Glu Arg Gln Val Phe Leu Ala Xaa Trp Lys Asp Ile Pro Asn Glu Asn 
        835                 840                 845             


Glu Leu Gln Phe Gln Ile Lys Glu Cys His Leu Asn Ala Asp Xaa Val 
    850                 855                 860                 


Ser Ser Lys Leu Gln Asn Asn Asn Val Tyr Xaa Ile Ala Lys Arg Asn 
865                 870                 875                 880 


Val Glu Gly Gln Asp Met Leu Tyr Gln Ser Leu Lys Leu Xaa Asn Gly 
                885                 890                 895     


Ile Trp Ile Leu Ala Glu Leu Arg Ile Gln Pro Gly Asn Pro Asn Tyr 
            900                 905                 910         


Xaa Leu Ser Leu Lys Cys Arg Ala Pro Glu Val Ser Gln Tyr Ile Tyr 
        915                 920                 925             


Gln Val Tyr Asp Ser Ile Leu Lys Asn 
    930                 935         


<210> 2465
<211> 951
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<400> 2465
Met Xaa Asp Ser Lys Tyr Phe Xaa Xaa Asn Lys Lys Gly Glu Ile Phe 
1               5                   10                  15      


Glu Leu Lys Ala Glu Leu Asn Asn Glu Lys Lys Glu Lys Arg Lys Glu 
            20                  25                  30          


Ala Val Lys Lys Val Ile Ala Ala Met Xaa Val Gly Lys Asp Val Ser 
        35                  40                  45              


Ser Leu Phe Pro Asp Val Val Asn Cys Met Gln Xaa Asp Asn Leu Glu 
    50                  55                  60                  


Leu Lys Lys Leu Val Tyr Leu Tyr Leu Met Asn Tyr Ala Lys Ser Gln 
65                  70                  75                  80  


Pro Asp Met Ala Ile Met Ala Val Asn Ser Phe Val Lys Asp Cys Glu 
                85                  90                  95      


Asp Pro Asn Pro Leu Ile Arg Ala Leu Ala Val Arg Xaa Met Gly Cys 
            100                 105                 110         


Ile Arg Val Asp Lys Ile Xaa Glu Tyr Leu Cys Glu Pro Leu Arg Lys 
        115                 120                 125             


Cys Leu Lys Asp Glu Asp Pro Tyr Val Arg Lys Xaa Ala Ala Val Cys 
    130                 135                 140                 


Val Ala Lys Leu His Asp Ile Asn Ala Gln Met Val Glu Asp Gln Gly 
145                 150                 155                 160 


Phe Leu Asp Ser Leu Arg Asp Leu Ile Ala Asp Ser Asn Pro Met Val 
                165                 170                 175     


Val Ala Asn Ala Val Ala Ala Leu Ser Glu Ile Ser Glu Ser His Pro 
            180                 185                 190         


Asn Ser Asn Leu Leu Asp Leu Asn Pro Gln Asn Ile Asn Lys Leu Leu 
        195                 200                 205             


Xaa Ala Leu Asn Glu Cys Xaa Glu Trp Gly Gln Ile Phe Ile Leu Asp 
    210                 215                 220                 


Cys Leu Ser Asn Tyr Asn Pro Lys Asp Asp Arg Glu Ala Gln Ser Ile 
225                 230                 235                 240 


Cys Glu Arg Val Xaa Pro Arg Leu Ser His Ala Asn Ser Ala Val Val 
                245                 250                 255     


Leu Ser Ala Val Lys Val Leu Met Lys Phe Leu Glu Leu Leu Pro Lys 
            260                 265                 270         


Asp Ser Asp Tyr Tyr Asn Met Leu Leu Lys Lys Leu Ala Pro Pro Leu 
        275                 280                 285             


Val Xaa Leu Leu Ser Gly Glu Pro Glu Val Gln Tyr Val Ala Leu Arg 
    290                 295                 300                 


Asn Ile Asn Leu Ile Val Gln Lys Arg Pro Glu Ile Leu Lys Gln Glu 
305                 310                 315                 320 


Ile Lys Val Phe Phe Val Lys Tyr Asn Asp Pro Ile Tyr Val Lys Leu 
                325                 330                 335     


Glu Lys Leu Asp Ile Met Ile Arg Leu Ala Ser Gln Ala Asn Ile Ala 
            340                 345                 350         


Gln Val Leu Ala Glu Leu Lys Glu Tyr Ala Xaa Glu Val Asp Val Asp 
        355                 360                 365             


Phe Val Arg Lys Ala Val Arg Ala Ile Gly Arg Cys Ala Ile Lys Val 
    370                 375                 380                 


Glu Gln Ser Ala Glu Arg Cys Val Ser Xaa Leu Leu Asp Leu Ile Gln 
385                 390                 395                 400 


Xaa Lys Val Asn Tyr Val Val Gln Glu Ala Ile Val Val Ile Arg Asp 
                405                 410                 415     


Ile Phe Arg Lys Tyr Pro Asn Lys Tyr Glu Ser Ile Ile Ala Xaa Leu 
            420                 425                 430         


Cys Glu Asn Leu Asp Ser Leu Asp Glu Pro Asp Ala Arg Ala Ala Met 
        435                 440                 445             


Ile Trp Ile Val Gly Glu Tyr Ala Glu Arg Ile Asp Asn Ala Asp Glu 
    450                 455                 460                 


Leu Leu Glu Ser Phe Leu Glu Gly Phe His Asp Glu Ser Xaa Gln Val 
465                 470                 475                 480 


Gln Leu Xaa Leu Leu Xaa Ala Ile Val Lys Leu Phe Leu Lys Lys Pro 
                485                 490                 495     


Ser Glu Xaa Gln Glu Leu Val Gln Gln Val Leu Ser Leu Ala Xaa Gln 
            500                 505                 510         


Asp Ser Asp Asn Pro Asp Leu Arg Asp Arg Gly Tyr Ile Tyr Trp Arg 
        515                 520                 525             


Leu Leu Ser Xaa Asp Pro Val Xaa Ala Lys Glu Val Val Leu Ser Glu 
    530                 535                 540                 


Lys Pro Leu Ile Ser Glu Glu Xaa Asp Leu Ile Glu Pro Xaa Leu Leu 
545                 550                 555                 560 


Asp Glu Leu Ile Cys His Ile Gly Ser Leu Ala Ser Val Tyr His Lys 
                565                 570                 575     


Pro Pro Asn Ala Phe Val Glu Gly Ser His Gly Ile His Arg Lys His 
            580                 585                 590         


Leu Pro Ile His His Gly Ser Xaa Asp Ala Gly Asp Ser Pro Val Gly 
        595                 600                 605             


Xaa Xaa Xaa Ala Xaa Asn Leu Glu Gln Pro Gln Val Ile Pro Ser Gln 
    610                 615                 620                 


Gly Asp Leu Leu Gly Asp Leu Leu Asn Leu Asp Leu Gly Pro Pro Val 
625                 630                 635                 640 


Asn Val Pro Gln Val Ser Ser Met Gln Met Gly Ala Val Asp Leu Leu 
                645                 650                 655     


Gly Gly Gly Leu Asp Ser Leu Leu Gly Ser Asp Leu Gly Gly Gly Ile 
            660                 665                 670         


Gly Gly Ser Pro Ala Val Gly Gln Ser Phe Ile Pro Ser Ser Val Pro 
        675                 680                 685             


Ala Xaa Phe Ala Pro Ser Pro Xaa Pro Ala Val Val Ser Ser Gly Leu 
    690                 695                 700                 


Asn Asp Leu Phe Glu Leu Ser Xaa Gly Ile Gly Met Ala Pro Gly Gly 
705                 710                 715                 720 


Tyr Val Ala Pro Lys Ala Val Trp Leu Pro Ala Val Lys Ala Lys Gly 
                725                 730                 735     


Leu Glu Ile Ser Gly Xaa Phe Xaa His Arg Gln Gly His Ile Tyr Met 
            740                 745                 750         


Glu Met Asn Phe Xaa Asn Lys Ala Leu Gln His Met Xaa Asp Phe Ala 
        755                 760                 765             


Ile Gln Phe Asn Lys Asn Ser Phe Gly Val Ile Pro Ser Xaa Pro Leu 
    770                 775                 780                 


Ala Ile His Xaa Pro Leu Met Pro Asn Gln Ser Ile Asp Val Ser Leu 
785                 790                 795                 800 


Pro Leu Asn Xaa Leu Gly Pro Val Met Lys Met Glu Pro Leu Asn Asn 
                805                 810                 815     


Leu Gln Val Ala Val Lys Asn Asn Ile Asp Val Phe Tyr Phe Ser Cys 
            820                 825                 830         


Leu Ile Pro Leu Asn Val Leu Phe Val Glu Asp Gly Lys Met Glu Arg 
        835                 840                 845             


Gln Val Phe Leu Ala Xaa Trp Lys Asp Ile Pro Asn Glu Asn Glu Leu 
    850                 855                 860                 


Gln Phe Gln Ile Lys Glu Cys His Leu Asn Ala Asp Xaa Val Ser Ser 
865                 870                 875                 880 


Lys Leu Gln Asn Asn Asn Val Tyr Xaa Ile Ala Lys Arg Asn Val Glu 
                885                 890                 895     


Gly Gln Asp Met Leu Tyr Gln Ser Leu Lys Leu Xaa Asn Gly Ile Trp 
            900                 905                 910         


Ile Leu Ala Glu Leu Arg Ile Gln Pro Gly Asn Pro Asn Tyr Xaa Leu 
        915                 920                 925             


Ser Leu Lys Cys Arg Ala Pro Glu Val Ser Gln Tyr Ile Tyr Gln Val 
    930                 935                 940                 


Tyr Asp Ser Ile Leu Lys Asn 
945                 950     


<210> 2466
<211> 639
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<400> 2466
Met Xaa Asp Ser Lys Tyr Phe Xaa Xaa Asn Lys Lys Gly Glu Ile Phe 
1               5                   10                  15      


Glu Leu Lys Ala Glu Leu Asn Asn Glu Lys Lys Glu Lys Arg Lys Glu 
            20                  25                  30          


Ala Val Lys Lys Val Ile Ala Ala Met Xaa Val Gly Lys Asp Val Ser 
        35                  40                  45              


Ser Leu Phe Pro Asp Val Val Asn Cys Met Gln Xaa Asp Asn Leu Glu 
    50                  55                  60                  


Leu Lys Lys Leu Val Tyr Leu Tyr Leu Met Asn Tyr Ala Lys Ser Gln 
65                  70                  75                  80  


Pro Asp Met Ala Ile Met Ala Val Asn Ser Phe Val Lys Asp Glu Asp 
                85                  90                  95      


Pro Tyr Val Arg Lys Xaa Ala Ala Val Cys Val Ala Lys Leu His Asp 
            100                 105                 110         


Ile Asn Ala Gln Met Val Glu Asp Gln Gly Phe Leu Asp Ser Leu Arg 
        115                 120                 125             


Asp Leu Ile Ala Asp Ser Asn Pro Met Val Val Ala Asn Ala Val Ala 
    130                 135                 140                 


Ala Leu Ser Glu Ile Ser Glu Ser His Pro Asn Ser Asn Leu Leu Asp 
145                 150                 155                 160 


Leu Asn Pro Gln Asn Ile Asn Lys Leu Leu Xaa Ala Leu Asn Glu Cys 
                165                 170                 175     


Xaa Glu Trp Gly Gln Ile Phe Ile Leu Asp Cys Leu Ser Asn Tyr Asn 
            180                 185                 190         


Pro Lys Asp Asp Arg Glu Ala Gln Ser Ile Cys Glu Arg Val Xaa Pro 
        195                 200                 205             


Arg Leu Ser His Ala Asn Ser Ala Val Val Leu Ser Ala Val Lys Val 
    210                 215                 220                 


Leu Met Lys Phe Leu Glu Leu Leu Pro Lys Asp Ser Asp Tyr Tyr Asn 
225                 230                 235                 240 


Met Leu Leu Lys Lys Leu Ala Pro Pro Leu Val Xaa Leu Leu Ser Gly 
                245                 250                 255     


Glu Pro Glu Val Gln Tyr Val Ala Leu Arg Asn Ile Asn Leu Ile Val 
            260                 265                 270         


Gln Lys Arg Pro Glu Ile Leu Lys Gln Glu Ile Lys Val Phe Phe Val 
        275                 280                 285             


Lys Tyr Asn Asp Pro Ile Tyr Val Lys Leu Glu Lys Leu Asp Ile Met 
    290                 295                 300                 


Ile Arg Leu Ala Ser Gln Ala Asn Ile Ala Gln Val Leu Ala Glu Leu 
305                 310                 315                 320 


Lys Glu Tyr Ala Xaa Glu Val Asp Val Asp Phe Val Arg Lys Ala Val 
                325                 330                 335     


Arg Ala Ile Gly Arg Cys Ala Ile Lys Val Glu Gln Ser Ala Glu Arg 
            340                 345                 350         


Cys Val Ser Xaa Leu Leu Asp Leu Ile Gln Xaa Lys Val Asn Tyr Val 
        355                 360                 365             


Val Gln Glu Ala Ile Val Val Ile Arg Asp Ile Phe Arg Lys Tyr Pro 
    370                 375                 380                 


Asn Lys Tyr Glu Ser Ile Ile Ala Xaa Leu Cys Glu Asn Leu Asp Ser 
385                 390                 395                 400 


Leu Asp Glu Pro Asp Ala Arg Ala Ala Met Ile Trp Ile Val Gly Glu 
                405                 410                 415     


Tyr Ala Glu Arg Ile Asp Asn Ala Asp Glu Leu Leu Glu Ser Phe Leu 
            420                 425                 430         


Glu Gly Phe His Asp Glu Ser Xaa Gln Val Gln Leu Xaa Leu Leu Xaa 
        435                 440                 445             


Ala Ile Val Lys Leu Phe Leu Lys Lys Pro Ser Glu Xaa Gln Glu Leu 
    450                 455                 460                 


Val Gln Gln Val Leu Ser Leu Ala Xaa Gln Asp Ser Asp Asn Pro Asp 
465                 470                 475                 480 


Leu Arg Asp Arg Gly Tyr Ile Tyr Trp Arg Leu Leu Ser Xaa Asp Pro 
                485                 490                 495     


Val Xaa Ala Lys Glu Val Val Leu Ser Glu Lys Pro Leu Ile Ser Glu 
            500                 505                 510         


Glu Xaa Asp Leu Ile Glu Pro Xaa Leu Leu Asp Glu Leu Ile Cys His 
        515                 520                 525             


Ile Gly Ser Leu Ala Ser Val Tyr His Lys Pro Pro Asn Ala Phe Val 
    530                 535                 540                 


Glu Gly Ser His Gly Ile His Arg Lys His Leu Pro Ile His His Gly 
545                 550                 555                 560 


Ser Xaa Asp Ala Gly Asp Ser Pro Val Gly Xaa Xaa Xaa Ala Xaa Asn 
                565                 570                 575     


Leu Glu Gln Pro Gln Val Ile Pro Ser Gln Gly Asp Leu Leu Gly Asp 
            580                 585                 590         


Leu Leu Asn Leu Asp Leu Gly Pro Pro Val Asn Val Pro Gln Val Ser 
        595                 600                 605             


Ser Met Gln Met Gly Ala Val Asp Leu Leu Gly Gly Gly Leu Asp Ser 
    610                 615                 620                 


Leu Leu Gly Ser Asp Leu Gly Gly Gly Ile Gly Gly Ser Pro Ala 
625                 630                 635                 


<210> 2467
<211> 913
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<400> 2467
Met Xaa Asp Ser Lys Tyr Phe Xaa Xaa Asn Lys Lys Gly Glu Ile Phe 
1               5                   10                  15      


Glu Leu Lys Ala Glu Leu Asn Asn Glu Lys Lys Glu Lys Arg Lys Glu 
            20                  25                  30          


Ala Val Lys Lys Val Ile Ala Ala Met Xaa Val Gly Lys Asp Val Ser 
        35                  40                  45              


Ser Leu Phe Pro Asp Val Val Asn Cys Met Gln Xaa Asp Asn Leu Glu 
    50                  55                  60                  


Leu Lys Lys Leu Val Tyr Leu Tyr Leu Met Asn Tyr Ala Lys Ser Gln 
65                  70                  75                  80  


Pro Asp Met Ala Ile Met Ala Val Asn Ser Phe Val Lys Asp Glu Asp 
                85                  90                  95      


Pro Tyr Val Arg Lys Xaa Ala Ala Val Cys Val Ala Lys Leu His Asp 
            100                 105                 110         


Ile Asn Ala Gln Met Val Glu Asp Gln Gly Phe Leu Asp Ser Leu Arg 
        115                 120                 125             


Asp Leu Ile Ala Asp Ser Asn Pro Met Val Val Ala Asn Ala Val Ala 
    130                 135                 140                 


Ala Leu Ser Glu Ile Ser Glu Ser His Pro Asn Ser Asn Leu Leu Asp 
145                 150                 155                 160 


Leu Asn Pro Gln Asn Ile Asn Lys Leu Leu Xaa Ala Leu Asn Glu Cys 
                165                 170                 175     


Xaa Glu Trp Gly Gln Ile Phe Ile Leu Asp Cys Leu Ser Asn Tyr Asn 
            180                 185                 190         


Pro Lys Asp Asp Arg Glu Ala Gln Ser Ile Cys Glu Arg Val Xaa Pro 
        195                 200                 205             


Arg Leu Ser His Ala Asn Ser Ala Val Val Leu Ser Ala Val Lys Val 
    210                 215                 220                 


Leu Met Lys Phe Leu Glu Leu Leu Pro Lys Asp Ser Asp Tyr Tyr Asn 
225                 230                 235                 240 


Met Leu Leu Lys Lys Leu Ala Pro Pro Leu Val Xaa Leu Leu Ser Gly 
                245                 250                 255     


Glu Pro Glu Val Gln Tyr Val Ala Leu Arg Asn Ile Asn Leu Ile Val 
            260                 265                 270         


Gln Lys Arg Pro Glu Ile Leu Lys Gln Glu Ile Lys Val Phe Phe Val 
        275                 280                 285             


Lys Tyr Asn Asp Pro Ile Tyr Val Lys Leu Glu Lys Leu Asp Ile Met 
    290                 295                 300                 


Ile Arg Leu Ala Ser Gln Ala Asn Ile Ala Gln Val Leu Ala Glu Leu 
305                 310                 315                 320 


Lys Glu Tyr Ala Xaa Glu Val Asp Val Asp Phe Val Arg Lys Ala Val 
                325                 330                 335     


Arg Ala Ile Gly Arg Cys Ala Ile Lys Val Glu Gln Ser Ala Glu Arg 
            340                 345                 350         


Cys Val Ser Xaa Leu Leu Asp Leu Ile Gln Xaa Lys Val Asn Tyr Val 
        355                 360                 365             


Val Gln Glu Ala Ile Val Val Ile Arg Asp Ile Phe Arg Lys Tyr Pro 
    370                 375                 380                 


Asn Lys Tyr Glu Ser Ile Ile Ala Xaa Leu Cys Glu Asn Leu Asp Ser 
385                 390                 395                 400 


Leu Asp Glu Pro Asp Ala Arg Ala Ala Met Ile Trp Ile Val Gly Glu 
                405                 410                 415     


Tyr Ala Glu Arg Ile Asp Asn Ala Asp Glu Leu Leu Glu Ser Phe Leu 
            420                 425                 430         


Glu Gly Phe His Asp Glu Ser Xaa Gln Val Gln Leu Xaa Leu Leu Xaa 
        435                 440                 445             


Ala Ile Val Lys Leu Phe Leu Lys Lys Pro Ser Glu Xaa Gln Glu Leu 
    450                 455                 460                 


Val Gln Gln Val Leu Ser Leu Ala Xaa Gln Asp Ser Asp Asn Pro Asp 
465                 470                 475                 480 


Leu Arg Asp Arg Gly Tyr Ile Tyr Trp Arg Leu Leu Ser Xaa Asp Pro 
                485                 490                 495     


Val Xaa Ala Lys Glu Val Val Leu Ser Glu Lys Pro Leu Ile Ser Glu 
            500                 505                 510         


Glu Xaa Asp Leu Ile Glu Pro Xaa Leu Leu Asp Glu Leu Ile Cys His 
        515                 520                 525             


Ile Gly Ser Leu Ala Ser Val Tyr His Lys Pro Pro Asn Ala Phe Val 
    530                 535                 540                 


Glu Gly Ser His Gly Ile His Arg Lys His Leu Pro Ile His His Gly 
545                 550                 555                 560 


Ser Xaa Asp Ala Gly Asp Ser Pro Val Gly Xaa Xaa Xaa Ala Xaa Asn 
                565                 570                 575     


Leu Glu Gln Pro Gln Val Ile Pro Ser Gln Gly Asp Leu Leu Gly Asp 
            580                 585                 590         


Leu Leu Asn Leu Asp Leu Gly Pro Pro Val Asn Val Pro Gln Val Ser 
        595                 600                 605             


Ser Met Gln Met Gly Ala Val Asp Leu Leu Gly Gly Gly Leu Asp Ser 
    610                 615                 620                 


Leu Leu Gly Ser Asp Leu Gly Gly Gly Ile Gly Gly Ser Pro Ala Val 
625                 630                 635                 640 


Gly Gln Ser Phe Ile Pro Ser Ser Val Pro Ala Xaa Phe Ala Pro Ser 
                645                 650                 655     


Pro Xaa Pro Ala Val Val Ser Ser Gly Leu Asn Asp Leu Phe Glu Leu 
            660                 665                 670         


Ser Xaa Gly Ile Gly Met Ala Pro Gly Gly Tyr Val Ala Pro Lys Ala 
        675                 680                 685             


Val Trp Leu Pro Ala Val Lys Ala Lys Gly Leu Glu Ile Ser Gly Xaa 
    690                 695                 700                 


Phe Xaa His Arg Gln Gly His Ile Tyr Met Glu Met Asn Phe Xaa Asn 
705                 710                 715                 720 


Lys Ala Leu Gln His Met Xaa Asp Phe Ala Ile Gln Phe Asn Lys Asn 
                725                 730                 735     


Ser Phe Gly Val Ile Pro Ser Xaa Pro Leu Ala Ile His Xaa Pro Leu 
            740                 745                 750         


Met Pro Asn Gln Ser Ile Asp Val Ser Leu Pro Leu Asn Xaa Leu Gly 
        755                 760                 765             


Pro Val Met Lys Met Glu Pro Leu Asn Asn Leu Gln Val Ala Val Lys 
    770                 775                 780                 


Asn Asn Ile Asp Val Phe Tyr Phe Ser Cys Leu Ile Pro Leu Asn Val 
785                 790                 795                 800 


Leu Phe Val Glu Asp Gly Lys Met Glu Arg Gln Val Phe Leu Ala Xaa 
                805                 810                 815     


Trp Lys Asp Ile Pro Asn Glu Asn Glu Leu Gln Phe Gln Ile Lys Glu 
            820                 825                 830         


Cys His Leu Asn Ala Asp Xaa Val Ser Ser Lys Leu Gln Asn Asn Asn 
        835                 840                 845             


Val Tyr Xaa Ile Ala Lys Arg Asn Val Glu Gly Gln Asp Met Leu Tyr 
    850                 855                 860                 


Gln Ser Leu Lys Leu Xaa Asn Gly Ile Trp Ile Leu Ala Glu Leu Arg 
865                 870                 875                 880 


Ile Gln Pro Gly Asn Pro Asn Tyr Xaa Leu Ser Leu Lys Cys Arg Ala 
                885                 890                 895     


Pro Glu Val Ser Gln Tyr Ile Tyr Gln Val Tyr Asp Ser Ile Leu Lys 
            900                 905                 910         


Asn 
    


<210> 2468
<211> 49
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<400> 2468
Met Xaa Asp Ser Lys Tyr Phe Xaa Xaa Asn Lys Lys Gly Glu Ile Phe 
1               5                   10                  15      


Glu Leu Lys Ala Glu Leu Asn Asn Glu Lys Lys Glu Lys Arg Lys Glu 
            20                  25                  30          


Ala Val Lys Lys Val Ile Ala Ala Met Xaa Val Gly Lys Asp Val Ser 
        35                  40                  45              


Xaa 
    


<210> 2469
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<400> 2469
Ser Glu Val Leu Ala Glu Leu Lys Glu Tyr Ala Xaa Glu Val Asp Val 
1               5                   10                  15      


Asp Phe Val Arg Lys Ala Val Arg Ala Ile Gly Arg Cys Ala Ile Lys 
            20                  25                  30          


Val Glu Gln Ser Ala Glu Arg Cys Val Ser Xaa Leu Leu Asp Leu Ile 
        35                  40                  45              


Gln Xaa Lys Val Asn Tyr Val Val Gln Glu Ala Ile Val Val Ile Arg 
    50                  55                  60                  


Asp Ile Phe Arg Lys Tyr Pro Asn Lys Tyr Glu Ser Ile Ile Ala Xaa 
65                  70                  75                  80  


Leu Cys Glu Asn Leu Asp Ser Leu Asp Glu Pro Asp Ala Arg Ala Ala 
                85                  90                  95      


Met Ile Trp Ile Val Gly Glu Tyr Ala Glu Arg Ile Asp Asn Ala Asp 
            100                 105                 110         


Glu Leu Leu Glu Ser Phe Leu Glu Gly Phe His Asp Glu Ser Xaa Gln 
        115                 120                 125             


Val Gln Leu Xaa Leu Leu Xaa Ala Ile Val Lys Leu Phe Leu Lys Lys 
    130                 135                 140                 


Pro Ser Glu Xaa Gln Glu Leu Val Gln Gln Val Leu Ser Leu Ala Xaa 
145                 150                 155                 160 


Gln Leu Lys Lys 
                


<210> 2470
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<400> 2470
Phe Lys Pro Ser Leu Leu Ala Gln Lys Ile Glu Val Arg Ile Pro Xaa 
1               5                   10                  15      


Pro Leu Asn Xaa Ser Gly Val Gln Val Ile Cys Met Lys Gly Lys Ala 
            20                  25                  30          


Lys Tyr Lys Ala Ser Glu Asn Ala Ile Val Trp Lys Ile Lys Arg Met 
        35                  40                  45              


Ala Gly Met Lys Glu Ser Gln Ile Ser Ala Glu Ile Glu Leu Leu Pro 
    50                  55                  60                  


Xaa Asn Asp Lys Lys Lys Trp Ala Arg Pro Pro Ile Ser Met Asn Phe 
65                  70                  75                  80  


Glu Val Trp Gln Arg Arg Gly Leu Glu Ser Cys Gln Gly Met Leu Glu 
                85                  90                  95      


Asp Leu Leu Glu Ile Ile Pro Ile Asn Cys Cys Xaa Leu Glu Val Arg 
            100                 105                 110         


Lys Leu Arg Pro Arg Lys Lys Asn Trp Leu 
        115                 120         


<210> 2471
<211> 160
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<400> 2471
Met Ile Gly Gly Leu Phe Ile Tyr Asn His Lys Gly Glu Val Leu Ile 
1               5                   10                  15      


Ser Arg Val Tyr Arg Asp Asp Ile Gly Asn Arg Arg Asn Ala Val Asp 
            20                  25                  30          


Ala Phe Arg Val Asn Val Ile His Ala Arg Gln Gln Val Arg Ser Pro 
        35                  40                  45              


Val Xaa Asn Ile Ala Arg Xaa Ser Phe Phe His Val Lys Arg Ser Asn 
    50                  55                  60                  


Ile Trp Leu Ala Ala Val Xaa Lys Gln Asn Val Asn Ala Ala Met Val 
65                  70                  75                  80  


Phe Glu Phe Leu Tyr Lys Met Cys Asp Val Met Ala Ala Tyr Phe Gly 
                85                  90                  95      


Lys Ile Ser Glu Glu Asn Ile Lys Asn Asn Phe Val Leu Ile Tyr Glu 
            100                 105                 110         


Leu Leu Asp Glu Ile Leu Asp Phe Gly Tyr Pro Gln Asn Ser Glu Xaa 
        115                 120                 125             


Gly Ala Leu Lys Xaa Phe Ile Xaa Gln Gln Gly Ile Lys Ser Gln His 
    130                 135                 140                 


Gln Xaa Lys Glu Glu Gln Ser Gln Ile Xaa Ser Gln Val Xaa Gly Gln 
145                 150                 155                 160 


<210> 2472
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<400> 2472
Met Ile Gly Gly Leu Phe Ile Tyr Asn His Lys Gly Glu Val Leu Ile 
1               5                   10                  15      


Ser Arg Val Tyr Arg Asp Asp Ile Gly Arg Asn Ala Val Asp Ala Phe 
            20                  25                  30          


Arg Val Asn Val Ile His Ala Arg Gln Gln Val Arg Ser Pro Val Xaa 
        35                  40                  45              


Asn Ile Ala Arg Xaa Ser Phe Phe His Val Lys Arg Ser Asn Ile Trp 
    50                  55                  60                  


Leu Ala Ala Val Xaa Lys Gln Asn Val Asn Ala Ala Met Val Phe Glu 
65                  70                  75                  80  


Phe Leu Tyr Lys Met Cys Asp Val Met Ala Ala Tyr Phe Gly Lys Ile 
                85                  90                  95      


Ser Glu Glu Asn Ile Lys Asn Asn Phe Val Leu Ile Tyr Glu Leu Leu 
            100                 105                 110         


Asp 
    


<210> 2473
<211> 252
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<400> 2473
Met Ile Gly Gly Leu Phe Ile Tyr Asn His Lys Gly Glu Val Leu Ile 
1               5                   10                  15      


Ser Arg Val Tyr Arg Asp Asp Ile Gly Arg Asn Ala Val Asp Ala Phe 
            20                  25                  30          


Arg Val Asn Val Ile His Ala Arg Gln Gln Val Arg Ser Pro Val Xaa 
        35                  40                  45              


Asn Ile Ala Arg Xaa Ser Phe Phe His Val Lys Arg Ser Asn Ile Trp 
    50                  55                  60                  


Leu Ala Ala Val Xaa Lys Gln Asn Val Asn Ala Ala Met Val Phe Glu 
65                  70                  75                  80  


Phe Leu Tyr Lys Met Cys Asp Val Met Ala Ala Tyr Phe Gly Lys Ile 
                85                  90                  95      


Ser Glu Glu Asn Ile Lys Asn Asn Phe Val Leu Ile Tyr Glu Leu Leu 
            100                 105                 110         


Asp Glu Ile Leu Asp Phe Gly Tyr Pro Gln Asn Ser Glu Xaa Gly Ala 
        115                 120                 125             


Leu Lys Xaa Phe Ile Xaa Gln Gln Gly Ile Lys Ser Gln His Gln Xaa 
    130                 135                 140                 


Lys Glu Glu Gln Ser Gln Ile Xaa Ser Gln Gly Lys Gly Xaa Ala Asp 
145                 150                 155                 160 


Glu Xaa Ser Lys Ser Gly Lys Gln Ser Ile Ala Ile Asp Asp Cys Xaa 
                165                 170                 175     


Phe His Gln Cys Val Arg Leu Ser Lys Phe Asp Ser Glu Arg Ser Ile 
            180                 185                 190         


Ser Phe Ile Pro Pro Asp Gly Glu Phe Glu Leu Met Arg Tyr Arg Xaa 
        195                 200                 205             


Xaa Lys Asp Ile Ile Leu Pro Phe Arg Val Ile Pro Leu Val Arg Glu 
    210                 215                 220                 


Val Gly Arg Xaa Lys Leu Glu Val Lys Val Val Ile Lys Ser Asn Phe 
225                 230                 235                 240 


Lys Pro Ser Leu Leu Ala Gln Lys Ile Glu Val Arg 
                245                 250         


<210> 2474
<211> 435
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<400> 2474
Met Ile Gly Gly Leu Phe Ile Tyr Asn His Lys Gly Glu Val Leu Ile 
1               5                   10                  15      


Ser Arg Val Tyr Arg Asp Asp Ile Gly Arg Asn Ala Val Asp Ala Phe 
            20                  25                  30          


Arg Val Asn Val Ile His Ala Arg Gln Gln Val Arg Ser Pro Val Xaa 
        35                  40                  45              


Asn Ile Ala Arg Xaa Ser Phe Phe His Val Lys Arg Ser Asn Ile Trp 
    50                  55                  60                  


Leu Ala Ala Val Xaa Lys Gln Asn Val Asn Ala Ala Met Val Phe Glu 
65                  70                  75                  80  


Phe Leu Tyr Lys Met Cys Asp Val Met Ala Ala Tyr Phe Gly Lys Ile 
                85                  90                  95      


Ser Glu Glu Asn Ile Lys Asn Asn Phe Val Leu Ile Tyr Glu Leu Leu 
            100                 105                 110         


Asp Glu Ile Leu Asp Phe Gly Tyr Pro Gln Asn Ser Glu Xaa Gly Ala 
        115                 120                 125             


Leu Lys Xaa Phe Ile Xaa Gln Gln Gly Ile Lys Ser Gln His Gln Xaa 
    130                 135                 140                 


Lys Glu Glu Gln Ser Gln Ile Xaa Ser Gln Val Xaa Gly Gln Ile Gly 
145                 150                 155                 160 


Trp Arg Arg Glu Gly Ile Lys Tyr Arg Arg Asn Glu Leu Phe Leu Asp 
                165                 170                 175     


Val Leu Glu Ser Val Asn Leu Leu Met Ser Pro Gln Gly Gln Val Leu 
            180                 185                 190         


Ser Ala His Val Ser Gly Arg Val Val Met Lys Ser Tyr Leu Ser Gly 
        195                 200                 205             


Met Pro Glu Cys Lys Phe Gly Met Asn Asp Lys Ile Val Ile Glu Lys 
    210                 215                 220                 


Gln Gly Lys Gly Xaa Ala Asp Glu Xaa Ser Lys Ser Gly Lys Gln Ser 
225                 230                 235                 240 


Ile Ala Ile Asp Asp Cys Xaa Phe His Gln Cys Val Arg Leu Ser Lys 
                245                 250                 255     


Phe Asp Ser Glu Arg Ser Ile Ser Phe Ile Pro Pro Asp Gly Glu Phe 
            260                 265                 270         


Glu Leu Met Arg Tyr Arg Xaa Xaa Lys Asp Ile Ile Leu Pro Phe Arg 
        275                 280                 285             


Val Ile Pro Leu Val Arg Glu Val Gly Arg Xaa Lys Leu Glu Val Lys 
    290                 295                 300                 


Val Val Ile Lys Ser Asn Phe Lys Pro Ser Leu Leu Ala Gln Lys Ile 
305                 310                 315                 320 


Glu Val Arg Ile Pro Xaa Pro Leu Asn Xaa Ser Gly Val Gln Val Ile 
                325                 330                 335     


Cys Met Lys Gly Lys Ala Lys Tyr Lys Ala Ser Glu Asn Ala Ile Val 
            340                 345                 350         


Trp Lys Ile Lys Arg Met Ala Gly Met Lys Glu Ser Gln Ile Ser Ala 
        355                 360                 365             


Glu Ile Glu Leu Leu Pro Xaa Asn Asp Lys Lys Lys Trp Ala Arg Pro 
    370                 375                 380                 


Pro Ile Ser Met Asn Phe Glu Val Pro Phe Ala Pro Ser Gly Leu Lys 
385                 390                 395                 400 


Val Arg Tyr Leu Lys Val Phe Glu Pro Lys Leu Asn Tyr Ser Asp His 
                405                 410                 415     


Asp Val Ile Lys Trp Val Arg Tyr Ile Gly Arg Ser Gly Ile Tyr Glu 
            420                 425                 430         


Xaa Arg Cys 
        435 


<210> 2475
<211> 195
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<400> 2475
Met Ile Gly Gly Leu Phe Ile Tyr Asn His Lys Gly Glu Val Leu Ile 
1               5                   10                  15      


Ser Arg Val Tyr Arg Asp Asp Ile Gly Arg Asn Ala Val Asp Ala Phe 
            20                  25                  30          


Arg Val Asn Val Ile His Ala Arg Gln Gln Val Arg Ser Pro Val Xaa 
        35                  40                  45              


Asn Ile Ala Arg Xaa Ser Phe Phe His Val Lys Arg Ser Asn Ile Trp 
    50                  55                  60                  


Leu Ala Ala Val Xaa Lys Gln Asn Val Asn Ala Ala Met Val Phe Glu 
65                  70                  75                  80  


Phe Leu Tyr Lys Met Cys Asp Val Met Ala Ala Tyr Phe Gly Lys Ile 
                85                  90                  95      


Ser Glu Glu Asn Ile Lys Asn Asn Phe Val Leu Ile Tyr Glu Leu Leu 
            100                 105                 110         


Asp Glu Ile Leu Asp Phe Gly Tyr Pro Gln Asn Ser Glu Xaa Gly Ala 
        115                 120                 125             


Leu Lys Xaa Phe Ile Xaa Gln Gln Gly Ile Lys Ser Gln His Gln Val 
    130                 135                 140                 


Ser Ser Ser Leu Ser Phe His Pro Cys Ser Phe Ala Leu Phe Leu Gln 
145                 150                 155                 160 


Ala Leu Pro Phe Gly Ala Tyr Arg Gly Lys Trp Ile Xaa Asp Lys Arg 
                165                 170                 175     


Arg Ala Val Xaa Asp His Gln Pro Gly Asn Trp Ala Asp Trp Leu Ala 
            180                 185                 190         


Ala Arg Gly 
        195 


<210> 2476
<211> 434
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<400> 2476
Met Ile Gly Gly Leu Phe Ile Tyr Asn His Lys Gly Glu Val Leu Ile 
1               5                   10                  15      


Ser Arg Val Tyr Arg Asp Asp Ile Gly Arg Asn Ala Val Asp Ala Phe 
            20                  25                  30          


Arg Val Asn Val Ile His Ala Arg Gln Gln Val Arg Ser Pro Val Xaa 
        35                  40                  45              


Asn Ile Ala Arg Xaa Ser Phe Phe His Val Lys Arg Ser Asn Ile Trp 
    50                  55                  60                  


Leu Ala Ala Val Xaa Lys Gln Asn Val Asn Ala Ala Met Val Phe Glu 
65                  70                  75                  80  


Phe Leu Tyr Lys Met Cys Asp Val Met Ala Ala Tyr Phe Gly Lys Ile 
                85                  90                  95      


Ser Glu Glu Asn Ile Lys Asn Asn Phe Val Leu Ile Tyr Glu Leu Leu 
            100                 105                 110         


Asp Glu Ile Leu Asp Phe Gly Tyr Pro Gln Asn Ser Glu Xaa Gly Ala 
        115                 120                 125             


Leu Lys Xaa Phe Ile Xaa Gln Gln Gly Ile Lys Ser Gln His Xaa Lys 
    130                 135                 140                 


Glu Glu Gln Ser Gln Ile Xaa Ser Gln Val Xaa Gly Gln Ile Gly Trp 
145                 150                 155                 160 


Arg Arg Glu Gly Ile Lys Tyr Arg Arg Asn Glu Leu Phe Leu Asp Val 
                165                 170                 175     


Leu Glu Ser Val Asn Leu Leu Met Ser Pro Gln Gly Gln Val Leu Ser 
            180                 185                 190         


Ala His Val Ser Gly Arg Val Val Met Lys Ser Tyr Leu Ser Gly Met 
        195                 200                 205             


Pro Glu Cys Lys Phe Gly Met Asn Asp Lys Ile Val Ile Glu Lys Gln 
    210                 215                 220                 


Gly Lys Gly Xaa Ala Asp Glu Xaa Ser Lys Ser Gly Lys Gln Ser Ile 
225                 230                 235                 240 


Ala Ile Asp Asp Cys Xaa Phe His Gln Cys Val Arg Leu Ser Lys Phe 
                245                 250                 255     


Asp Ser Glu Arg Ser Ile Ser Phe Ile Pro Pro Asp Gly Glu Phe Glu 
            260                 265                 270         


Leu Met Arg Tyr Arg Xaa Xaa Lys Asp Ile Ile Leu Pro Phe Arg Val 
        275                 280                 285             


Ile Pro Leu Val Arg Glu Val Gly Arg Xaa Lys Leu Glu Val Lys Val 
    290                 295                 300                 


Val Ile Lys Ser Asn Phe Lys Pro Ser Leu Leu Ala Gln Lys Ile Glu 
305                 310                 315                 320 


Val Arg Ile Pro Xaa Pro Leu Asn Xaa Ser Gly Val Gln Val Ile Cys 
                325                 330                 335     


Met Lys Gly Lys Ala Lys Tyr Lys Ala Ser Glu Asn Ala Ile Val Trp 
            340                 345                 350         


Lys Ile Lys Arg Met Ala Gly Met Lys Glu Ser Gln Ile Ser Ala Glu 
        355                 360                 365             


Ile Glu Leu Leu Pro Xaa Asn Asp Lys Lys Lys Trp Ala Arg Pro Pro 
    370                 375                 380                 


Ile Ser Met Asn Phe Glu Val Pro Phe Ala Pro Ser Gly Leu Lys Val 
385                 390                 395                 400 


Arg Tyr Leu Lys Val Phe Glu Pro Lys Leu Asn Tyr Ser Asp His Asp 
                405                 410                 415     


Val Ile Lys Trp Val Arg Tyr Ile Gly Arg Ser Gly Ile Tyr Glu Xaa 
            420                 425                 430         


Arg Cys 
        


<210> 2477
<211> 433
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<400> 2477
Met Ile Gly Gly Leu Phe Ile Tyr Asn His Lys Gly Glu Val Leu Ile 
1               5                   10                  15      


Ser Arg Val Tyr Arg Asp Asp Ile Gly Arg Asn Ala Val Asp Ala Phe 
            20                  25                  30          


Arg Val Asn Val Ile His Ala Arg Gln Gln Val Arg Ser Pro Val Xaa 
        35                  40                  45              


Asn Ile Ala Arg Xaa Ser Phe Phe His Val Lys Arg Ser Asn Ile Trp 
    50                  55                  60                  


Leu Ala Ala Val Xaa Lys Gln Asn Val Asn Ala Ala Met Val Phe Glu 
65                  70                  75                  80  


Phe Leu Tyr Lys Met Cys Asp Val Met Ala Ala Tyr Phe Gly Lys Ile 
                85                  90                  95      


Ser Glu Glu Asn Ile Lys Asn Asn Phe Val Leu Ile Tyr Glu Leu Leu 
            100                 105                 110         


Asp Glu Ile Leu Asp Phe Gly Tyr Pro Gln Asn Ser Glu Xaa Gly Ala 
        115                 120                 125             


Leu Lys Xaa Phe Ile Xaa Gln Gln Gly Ile Lys Ser Gln Xaa Lys Glu 
    130                 135                 140                 


Glu Gln Ser Gln Ile Xaa Ser Gln Val Xaa Gly Gln Ile Gly Trp Arg 
145                 150                 155                 160 


Arg Glu Gly Ile Lys Tyr Arg Arg Asn Glu Leu Phe Leu Asp Val Leu 
                165                 170                 175     


Glu Ser Val Asn Leu Leu Met Ser Pro Gln Gly Gln Val Leu Ser Ala 
            180                 185                 190         


His Val Ser Gly Arg Val Val Met Lys Ser Tyr Leu Ser Gly Met Pro 
        195                 200                 205             


Glu Cys Lys Phe Gly Met Asn Asp Lys Ile Val Ile Glu Lys Gln Gly 
    210                 215                 220                 


Lys Gly Xaa Ala Asp Glu Xaa Ser Lys Ser Gly Lys Gln Ser Ile Ala 
225                 230                 235                 240 


Ile Asp Asp Cys Xaa Phe His Gln Cys Val Arg Leu Ser Lys Phe Asp 
                245                 250                 255     


Ser Glu Arg Ser Ile Ser Phe Ile Pro Pro Asp Gly Glu Phe Glu Leu 
            260                 265                 270         


Met Arg Tyr Arg Xaa Xaa Lys Asp Ile Ile Leu Pro Phe Arg Val Ile 
        275                 280                 285             


Pro Leu Val Arg Glu Val Gly Arg Xaa Lys Leu Glu Val Lys Val Val 
    290                 295                 300                 


Ile Lys Ser Asn Phe Lys Pro Ser Leu Leu Ala Gln Lys Ile Glu Val 
305                 310                 315                 320 


Arg Ile Pro Xaa Pro Leu Asn Xaa Ser Gly Val Gln Val Ile Cys Met 
                325                 330                 335     


Lys Gly Lys Ala Lys Tyr Lys Ala Ser Glu Asn Ala Ile Val Trp Lys 
            340                 345                 350         


Ile Lys Arg Met Ala Gly Met Lys Glu Ser Gln Ile Ser Ala Glu Ile 
        355                 360                 365             


Glu Leu Leu Pro Xaa Asn Asp Lys Lys Lys Trp Ala Arg Pro Pro Ile 
    370                 375                 380                 


Ser Met Asn Phe Glu Val Pro Phe Ala Pro Ser Gly Leu Lys Val Arg 
385                 390                 395                 400 


Tyr Leu Lys Val Phe Glu Pro Lys Leu Asn Tyr Ser Asp His Asp Val 
                405                 410                 415     


Ile Lys Trp Val Arg Tyr Ile Gly Arg Ser Gly Ile Tyr Glu Xaa Arg 
            420                 425                 430         


Cys 
    


<210> 2478
<211> 460
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<400> 2478
Met Ile Gly Gly Leu Phe Ile Tyr Asn His Lys Gly Glu Val Leu Ile 
1               5                   10                  15      


Ser Arg Val Tyr Arg Asp Asp Ile Gly Ser Arg Gln Ala Ala Asp Ser 
            20                  25                  30          


Ala Val Phe Ser Ser Ser Gly Pro Phe Pro Gly Glu Trp Leu Glu Ala 
        35                  40                  45              


Asn Arg Arg Asn Ala Val Asp Ala Phe Arg Val Asn Val Ile His Ala 
    50                  55                  60                  


Arg Gln Gln Val Arg Ser Pro Val Xaa Asn Ile Ala Arg Xaa Ser Phe 
65                  70                  75                  80  


Phe His Val Lys Arg Ser Asn Ile Trp Leu Ala Ala Val Xaa Lys Gln 
                85                  90                  95      


Asn Val Asn Ala Ala Met Val Phe Glu Phe Leu Tyr Lys Met Cys Asp 
            100                 105                 110         


Val Met Ala Ala Tyr Phe Gly Lys Ile Ser Glu Glu Asn Ile Lys Asn 
        115                 120                 125             


Asn Phe Val Leu Ile Tyr Glu Leu Leu Asp Glu Ile Leu Asp Phe Gly 
    130                 135                 140                 


Tyr Pro Gln Asn Ser Glu Xaa Gly Ala Leu Lys Xaa Phe Ile Xaa Gln 
145                 150                 155                 160 


Gln Gly Ile Lys Ser Gln His Gln Xaa Lys Glu Glu Gln Ser Gln Ile 
                165                 170                 175     


Xaa Ser Gln Val Xaa Gly Gln Ile Gly Trp Arg Arg Glu Gly Ile Lys 
            180                 185                 190         


Tyr Arg Arg Asn Glu Leu Phe Leu Asp Val Leu Glu Ser Val Asn Leu 
        195                 200                 205             


Leu Met Ser Pro Gln Gly Gln Val Leu Ser Ala His Val Ser Gly Arg 
    210                 215                 220                 


Val Val Met Lys Ser Tyr Leu Ser Gly Met Pro Glu Cys Lys Phe Gly 
225                 230                 235                 240 


Met Asn Asp Lys Ile Val Ile Glu Lys Gln Gly Lys Gly Xaa Ala Asp 
                245                 250                 255     


Glu Xaa Ser Lys Ser Gly Lys Gln Ser Ile Ala Ile Asp Asp Cys Xaa 
            260                 265                 270         


Phe His Gln Cys Val Arg Leu Ser Lys Phe Asp Ser Glu Arg Ser Ile 
        275                 280                 285             


Ser Phe Ile Pro Pro Asp Gly Glu Phe Glu Leu Met Arg Tyr Arg Xaa 
    290                 295                 300                 


Xaa Lys Asp Ile Ile Leu Pro Phe Arg Val Ile Pro Leu Val Arg Glu 
305                 310                 315                 320 


Val Gly Arg Xaa Lys Leu Glu Val Lys Val Val Ile Lys Ser Asn Phe 
                325                 330                 335     


Lys Pro Ser Leu Leu Ala Gln Lys Ile Glu Val Arg Ile Pro Xaa Pro 
            340                 345                 350         


Leu Asn Xaa Ser Gly Val Gln Val Ile Cys Met Lys Gly Lys Ala Lys 
        355                 360                 365             


Tyr Lys Ala Ser Glu Asn Ala Ile Val Trp Lys Ile Lys Arg Met Ala 
    370                 375                 380                 


Gly Met Lys Glu Ser Gln Ile Ser Ala Glu Ile Glu Leu Leu Pro Xaa 
385                 390                 395                 400 


Asn Asp Lys Lys Lys Trp Ala Arg Pro Pro Ile Ser Met Asn Phe Glu 
                405                 410                 415     


Val Pro Phe Ala Pro Ser Gly Leu Lys Val Arg Tyr Leu Lys Val Phe 
            420                 425                 430         


Glu Pro Lys Leu Asn Tyr Ser Asp His Asp Val Ile Lys Trp Val Arg 
        435                 440                 445             


Tyr Ile Gly Arg Ser Gly Ile Tyr Glu Xaa Arg Cys 
    450                 455                 460 


<210> 2479
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 2479
Met Ile Gly Gly Leu Phe Ile Tyr Asn His Lys Gly Glu Val Leu Ile 
1               5                   10                  15      


Ser Arg Val Tyr Arg Asp Asp Ile Gly Ser Arg Gln Ala Ala Asp Ser 
            20                  25                  30          


Ala Val Phe Ser Ser Ser Gly Pro Phe Pro Gly Glu Trp Leu Glu Ala 
        35                  40                  45              


Arg Asn Ala Val Asp Ala Phe Arg Val Asn Val Ile His Ala Arg Gln 
    50                  55                  60                  


Gln Val Arg Ser Pro Val Xaa Asn Ile Ala Arg Xaa Ser Phe Phe His 
65                  70                  75                  80  


Val Lys Arg Ser Asn Ile Trp Leu Ala Ala Val Xaa Lys Gln Asn Val 
                85                  90                  95      


Asn Ala Ala Met Val Phe Glu Phe Leu Tyr Lys Met Cys Asp Val Met 
            100                 105                 110         


Ala Ala Tyr Phe Gly Lys Ile Ser Glu Glu Asn Ile Lys Asn Asn Phe 
        115                 120                 125             


Val Leu Ile Tyr Glu Leu Leu Asp 
    130                 135     


<210> 2480
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<400> 2480
Met Phe Arg Asn Phe Lys Ile Ile Tyr Arg Arg Tyr Ala Gly Leu Tyr 
1               5                   10                  15      


Phe Cys Ile Cys Val Asp Val Asn Asp Asn Asn Leu Ala Tyr Leu Glu 
            20                  25                  30          


Ala Ile His Asn Phe Val Glu Val Leu Asn Glu Tyr Phe His Asn Val 
        35                  40                  45              


Cys Glu Leu Asp Leu Val Phe Asn Phe Tyr Lys Val Tyr Xaa Val Val 
    50                  55                  60                  


Asp Glu Met Phe Leu Ala Gly Glu Ile Arg Glu Xaa Ser Gln Xaa Lys 
65                  70                  75                  80  


Val Leu Lys Gln Leu Leu Met Leu Gln Ser Leu Glu 
                85                  90          


<210> 2481
<211> 142
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 2481
Met Ile Arg Phe Ile Leu Ile Gln Asn Arg Ala Gly Lys Xaa Arg Leu 
1               5                   10                  15      


Ala Lys Trp Tyr Met Gln Phe Asp Asp Asp Glu Lys Gln Lys Leu Ile 
            20                  25                  30          


Glu Glu Val His Ala Val Val Xaa Val Arg Asp Ala Lys His Xaa Asn 
        35                  40                  45              


Phe Val Glu Phe Arg Asn Phe Lys Ile Ile Tyr Arg Arg Tyr Ala Gly 
    50                  55                  60                  


Leu Tyr Phe Cys Ile Cys Val Asp Val Asn Asp Asn Asn Leu Ala Tyr 
65                  70                  75                  80  


Leu Glu Ala Ile His Asn Phe Val Glu Val Leu Asn Glu Tyr Phe His 
                85                  90                  95      


Asn Val Cys Glu Leu Asp Leu Val Phe Asn Phe Tyr Lys Val Tyr Xaa 
            100                 105                 110         


Val Val Asp Glu Met Phe Leu Ala Gly Glu Ile Arg Glu Xaa Ser Gln 
        115                 120                 125             


Xaa Lys Val Leu Lys Gln Leu Leu Met Leu Gln Ser Leu Glu 
    130                 135                 140         


<210> 2482
<211> 156
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<400> 2482
Met Ile Arg Phe Ile Leu Ile Gln Asn Arg Ala Gly Lys Xaa Arg Leu 
1               5                   10                  15      


Ala Lys Trp Tyr Met Gln Phe Asp Asp Asp Glu Lys Gln Lys Leu Ile 
            20                  25                  30          


Glu Glu Val His Ala Val Val Xaa Val Arg Asp Ala Lys His Xaa Asn 
        35                  40                  45              


Phe Val Glu Val Leu Ala Ile Ser Val Ala Asp Ser Leu Ser Val Leu 
    50                  55                  60                  


Gln Phe Arg Asn Phe Lys Ile Ile Tyr Arg Arg Tyr Ala Gly Leu Tyr 
65                  70                  75                  80  


Phe Cys Ile Cys Val Asp Val Asn Asp Asn Asn Leu Ala Tyr Leu Glu 
                85                  90                  95      


Ala Ile His Asn Phe Val Glu Val Leu Asn Glu Tyr Phe His Asn Val 
            100                 105                 110         


Cys Glu Leu Asp Leu Val Phe Asn Phe Tyr Lys Val Tyr Xaa Val Val 
        115                 120                 125             


Asp Glu Met Phe Leu Ala Gly Glu Ile Arg Glu Xaa Ser Gln Xaa Lys 
    130                 135                 140                 


Val Leu Lys Gln Leu Leu Met Leu Gln Ser Leu Glu 
145                 150                 155     


<210> 2483
<211> 104
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<400> 2483
Met Ile Arg Phe Ile Leu Ile Gln Asn Arg Ala Gly Lys Xaa Arg Leu 
1               5                   10                  15      


Ala Lys Trp Tyr Met Gln Phe Asp Asp Asp Glu Lys Gln Lys Leu Ile 
            20                  25                  30          


Glu Glu Val His Ala Val Val Xaa Val Arg Asp Ala Lys His Xaa Asn 
        35                  40                  45              


Phe Val Glu Val Leu Asn Glu Tyr Phe His Asn Val Cys Glu Leu Asp 
    50                  55                  60                  


Leu Val Phe Asn Phe Tyr Lys Val Tyr Xaa Val Val Asp Glu Met Phe 
65                  70                  75                  80  


Leu Ala Gly Glu Ile Arg Glu Xaa Ser Gln Xaa Lys Val Leu Lys Gln 
                85                  90                  95      


Leu Leu Met Leu Gln Ser Leu Glu 
            100                 


<210> 2484
<211> 158
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<400> 2484
Met Lys Leu Lys Gly Leu Gly Lys Arg Cys Lys Arg Arg Glu Asp Leu 
1               5                   10                  15      


Glu Ile Arg Phe Ile Leu Ile Gln Asn Arg Ala Gly Lys Xaa Arg Leu 
            20                  25                  30          


Ala Lys Trp Tyr Met Gln Phe Asp Asp Asp Glu Lys Gln Lys Leu Ile 
        35                  40                  45              


Glu Glu Val His Ala Val Val Xaa Val Arg Asp Ala Lys His Xaa Asn 
    50                  55                  60                  


Phe Val Glu Phe Arg Asn Phe Lys Ile Ile Tyr Arg Arg Tyr Ala Gly 
65                  70                  75                  80  


Leu Tyr Phe Cys Ile Cys Val Asp Val Asn Asp Asn Asn Leu Ala Tyr 
                85                  90                  95      


Leu Glu Ala Ile His Asn Phe Val Glu Val Leu Asn Glu Tyr Phe His 
            100                 105                 110         


Asn Val Cys Glu Leu Asp Leu Val Phe Asn Phe Tyr Lys Val Tyr Xaa 
        115                 120                 125             


Val Val Asp Glu Met Phe Leu Ala Gly Glu Ile Arg Glu Xaa Ser Gln 
    130                 135                 140                 


Xaa Lys Val Leu Lys Gln Leu Leu Met Leu Gln Ser Leu Glu 
145                 150                 155             


<210> 2485
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<400> 2485
Met Gln Phe Asp Asp Asp Glu Lys Gln Lys Leu Ile Glu Glu Val His 
1               5                   10                  15      


Ala Val Val Xaa Val Arg Asp Ala Lys His Xaa Asn Phe Val Glu Phe 
            20                  25                  30          


Arg Asn Phe Lys Ile Ile Tyr Arg Arg Tyr Ala Gly Leu Tyr Phe Cys 
        35                  40                  45              


Ile Cys Val Asp Val Asn Asp Asn Asn Leu Ala Tyr Leu Glu Ala Ile 
    50                  55                  60                  


His Asn Phe Val Glu Val Leu Asn Glu Tyr Phe His Asn Val Cys Glu 
65                  70                  75                  80  


Leu Asp Leu Val Phe Asn Phe Tyr Lys Val Tyr Xaa Val Val Asp Glu 
                85                  90                  95      


Met Phe Leu Ala Gly Glu Ile Arg Glu Xaa Ser Gln Xaa Lys Val Leu 
            100                 105                 110         


Lys Gln Leu Leu Met Leu Gln Ser Leu Glu 
        115                 120         


<210> 2486
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<400> 2486
Met Val Trp Ile Arg Phe Ile Leu Ile Gln Asn Arg Ala Gly Lys Xaa 
1               5                   10                  15      


Arg Leu Ala Lys Trp Tyr Met Gln Phe Asp Asp Asp Glu Lys Gln Lys 
            20                  25                  30          


Leu Ile Glu Glu Val His Ala Val Val Xaa Val Arg Asp Ala Lys His 
        35                  40                  45              


Xaa Asn Phe Val Glu Phe Arg Asn Phe Lys Ile Ile Tyr Arg Arg Tyr 
    50                  55                  60                  


Ala Gly Leu Tyr Phe Cys Ile Cys Val Asp Val Asn Asp Asn Asn Leu 
65                  70                  75                  80  


Ala Tyr Leu Glu Ala Ile His Asn Phe Val Glu Val Leu Asn Glu Tyr 
                85                  90                  95      


Phe His Asn Val Cys Glu Leu Asp Leu Val Phe Asn Phe Tyr Lys Val 
            100                 105                 110         


Tyr Xaa Val Val Asp Glu Met Phe Leu Ala Gly Glu Ile Arg Glu Xaa 
        115                 120                 125             


Ser Gln Xaa Lys Val Leu Lys Gln Leu Leu Met Leu Gln Ser Leu Glu 
    130                 135                 140                 


<210> 2487
<211> 193
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<400> 2487
Met Ile Lys Ala Ile Leu Ile Phe Asn Asn His Gly Lys Pro Arg Leu 
1               5                   10                  15      


Ser Lys Phe Tyr Gln Pro Tyr Ser Glu Asp Xaa Gln Gln Gln Ile Ile 
            20                  25                  30          


Arg Glu Xaa Phe His Leu Val Ser Lys Arg Asp Glu Asn Val Cys Asn 
        35                  40                  45              


Phe Leu Glu Gly Gly Leu Leu Ile Gly Gly Ser Asp Asn Lys Leu Ile 
    50                  55                  60                  


Tyr Arg His Tyr Ala Xaa Leu Tyr Phe Val Phe Cys Val Asp Ser Ser 
65                  70                  75                  80  


Glu Ser Glu Leu Gly Ile Leu Asp Leu Ile Gln Val Phe Val Glu Xaa 
                85                  90                  95      


Leu Asp Lys Cys Phe Glu Asn Val Cys Glu Leu Asp Leu Ile Phe His 
            100                 105                 110         


Val Asp Lys Val His Asn Ile Leu Ala Glu Met Val Met Gly Gly Met 
        115                 120                 125             


Val Leu Glu Xaa Asn Met Asn Glu Ile Val Xaa Gln Ile Asp Ala Gln 
    130                 135                 140                 


Asn Lys Leu Glu Lys Ser Glu Ala Gly Leu Ala Gly Ala Pro Ala Arg 
145                 150                 155                 160 


Ala Val Ser Ala Val Lys Asn Met Asn Leu Pro Glu Ile Pro Arg Asn 
                165                 170                 175     


Ile Asn Ile Gly Asp Ile Ser Ile Lys Val Pro Asn Leu Pro Ser Phe 
            180                 185                 190         


Lys 
    


<210> 2488
<211> 162
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<400> 2488
Met Ile Lys Ala Ile Leu Ile Phe Asn Asn His Gly Lys Pro Arg Leu 
1               5                   10                  15      


Ser Lys Phe Tyr Gln Pro Tyr Ser Glu Asp Xaa Gln Gln Gln Ile Ile 
            20                  25                  30          


Arg Glu Xaa Phe His Leu Val Ser Lys Arg Asp Glu Asn Val Cys Asn 
        35                  40                  45              


Phe Leu Glu Gly Gly Leu Leu Ile Gly Gly Ser Asp Asn Lys Leu Ile 
    50                  55                  60                  


Tyr Arg His Tyr Ala Xaa Leu Tyr Phe Val Phe Cys Val Asp Ser Ser 
65                  70                  75                  80  


Glu Ser Glu Leu Gly Ile Leu Asp Leu Ile Gln Val Phe Val Glu Xaa 
                85                  90                  95      


Leu Asp Lys Cys Phe Glu Asn Val Cys Glu Leu Asp Leu Ile Phe His 
            100                 105                 110         


Val Asp Lys Val His Asn Ile Leu Ala Glu Met Val Met Gly Gly Met 
        115                 120                 125             


Val Leu Glu Xaa Asn Met Asn Glu Ile Val Xaa Gln Ile Asp Ala Gln 
    130                 135                 140                 


Asn Lys Leu Glu Lys Ser Glu Xaa Phe Ile Phe Gln Ser Pro Arg Gln 
145                 150                 155                 160 


Asp Arg 
        


<210> 2489
<211> 807
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<400> 2489
Met Phe Ser Ala Gly Ala Glu Ser Leu Leu His Gln Ala Arg Glu Ile 
1               5                   10                  15      


Gln Asp Glu Glu Leu Lys Lys Phe Cys Ser Arg Ile Cys Lys Leu Leu 
            20                  25                  30          


Gln Ala Glu Asp Leu Gly Pro Asp Xaa Leu Asp Ser Leu Gln Arg Leu 
        35                  40                  45              


Phe Leu Ile Ile Ser Ala Xaa Lys Tyr Ser Arg Arg Leu Glu Lys Xaa 
    50                  55                  60                  


Cys Val Asp Leu Leu Gln Ala Xaa Leu Gly Leu Pro Ala Cys Pro Glu 
65                  70                  75                  80  


Gln Leu Gln Val Leu Cys Ala Ala Ile Leu Arg Glu Met Ser Pro Ser 
                85                  90                  95      


Asp Ser Leu Ser Leu Ala Trp Asp His Xaa Gln Asn Ser Arg Gln Leu 
            100                 105                 110         


Ser Leu Val Ala Ser Val Leu Leu Ala Gln Gly Asp Arg Asn Glu Glu 
        115                 120                 125             


Val Arg Ala Val Gly Gln Gly Val Leu Arg Ala Leu Glu Ser Arg Gln 
    130                 135                 140                 


Pro Glu Gly Pro Ser Leu Arg His Leu Leu Pro Val Met Ala Lys Val 
145                 150                 155                 160 


Val Val Leu Ser Pro Gly Xaa Leu Gln Glu Asp Gln Ala Xaa Leu Leu 
                165                 170                 175     


Ser Lys Arg Leu Val Asp Trp Leu Arg Tyr Ala Ser Leu Gln Gln Gly 
            180                 185                 190         


Leu Pro His Ser Gly Gly Phe Phe Ser Xaa Pro Arg Ala Arg Gln Pro 
        195                 200                 205             


Gly Pro Val Xaa Glu Val Asp Gly Ala Val Ala Xaa Asp Phe Phe Xaa 
    210                 215                 220                 


Val Leu Ser Ser Gly His Arg Phe Xaa Asp Asp Gln Trp Leu Asn Val 
225                 230                 235                 240 


Gln Ala Phe Ser Met Leu Arg Ala Trp Leu Leu His Ser Gly Pro Glu 
                245                 250                 255     


Gly Pro Gly Xaa Leu Asp Xaa Asp Asp Arg Ser Glu Gln Glu Gly Ser 
            260                 265                 270         


Xaa Leu Ser Val Ile Ser Ala Xaa Ser Ser Ala Gly Arg Leu Leu Pro 
        275                 280                 285             


Pro Arg Glu Arg Leu Arg Glu Val Ala Phe Glu Tyr Cys Gln Arg Leu 
    290                 295                 300                 


Ile Glu Gln Ser Asn Arg Arg Ala Leu Arg Lys Gly Asp Ser Asp Leu 
305                 310                 315                 320 


Gln Lys Ala Cys Leu Val Glu Ala Val Leu Val Leu Asp Val Leu Cys 
                325                 330                 335     


Arg Gln Asp Pro Ser Phe Leu Tyr Arg Ser Leu Ser Cys Leu Lys Ala 
            340                 345                 350         


Leu His Gly Arg Val Arg Gly Asp Pro Ala Ser Val Arg Val Leu Leu 
        355                 360                 365             


Pro Leu Ala His Phe Phe Leu Ser His Gly Glu Ala Ala Ala Val Asp 
    370                 375                 380                 


Ser Glu Ala Val Tyr Gln His Leu Phe Xaa Arg Ile Pro Val Glu Gln 
385                 390                 395                 400 


Phe His Ser Pro Met Leu Ala Phe Glu Phe Ile Gln Phe Cys Arg Asp 
                405                 410                 415     


Asn Leu His Leu Phe Ser Gly His Leu Ser Xaa Leu Arg Leu Ser Phe 
            420                 425                 430         


Pro Asn Leu Phe Lys Phe Leu Ala Trp Asn Ser Pro Pro Leu Xaa Ser 
        435                 440                 445             


Glu Phe Val Ala Leu Leu Pro Ala Leu Val Asp Ala Gly Xaa Ala Leu 
    450                 455                 460                 


Glu Met Leu His Ala Leu Leu Asp Leu Pro Cys Leu Xaa Ala Val Leu 
465                 470                 475                 480 


Asp Leu Gln Leu Arg Ser Ala Pro Ala Ala Ser Glu Arg Pro Leu Trp 
                485                 490                 495     


Asp Xaa Ser Leu Arg Ala Pro Ser Cys Leu Glu Ala Phe Arg Asp Pro 
            500                 505                 510         


Gln Phe Gln Gly Leu Phe Gln Tyr Leu Leu Arg Pro Lys Ala Ser Gly 
        515                 520                 525             


Ala Xaa Glu Arg Leu Ala Pro Leu His Gln Leu Leu Gln Pro Met Ala 
    530                 535                 540                 


Gly Cys Ala Arg Val Ala Gln Cys Ala Gln Ala Val Pro Xaa Leu Leu 
545                 550                 555                 560 


Gln Ala Phe Phe Ser Ala Val Xaa Gln Val Ala Asp Gly Ser Leu Ile 
                565                 570                 575     


Asn Gln Leu Ala Leu Leu Leu Leu Gly Arg Ser Asp Ser Leu Tyr Pro 
            580                 585                 590         


Ala Pro Gly Tyr Ala Ala Gly Val His Ser Val Leu Ser Ser Gln Phe 
        595                 600                 605             


Leu Ala Leu Cys Xaa Leu Lys Pro Ser Leu Val Val Glu Leu Ala Arg 
    610                 615                 620                 


Asp Leu Leu Glu Phe Leu Gly Ser Val Asn Gly Leu Cys Ser Arg Ala 
625                 630                 635                 640 


Ser Leu Val Xaa Ser Val Val Trp Ala Ile Gly Glu Tyr Leu Ser Val 
                645                 650                 655     


Xaa Tyr Asp Arg Arg Cys Xaa Val Glu Gln Ile Asn Lys Phe Phe Glu 
            660                 665                 670         


Ala Leu Glu Ala Leu Leu Phe Glu Val Xaa Gln Cys Arg Pro Ser Ala 
        675                 680                 685             


Ala Leu Pro Arg Cys Pro Pro Gln Val Val Xaa Val Leu Met Xaa Xaa 
    690                 695                 700                 


Leu Xaa Lys Leu Ala Ser Arg Ser Gln Asp Leu Ile Pro Arg Ala Ser 
705                 710                 715                 720 


Leu Leu Leu Ser Lys Met Arg Xaa Leu Ala His Ser Pro Ala Xaa Ser 
                725                 730                 735     


Ser Xaa His Ser Glu Glu Gly Ala Glu Ala Ile Arg Xaa Arg Ala Xaa 
            740                 745                 750         


Glu Leu Leu Xaa Leu Leu Lys Met Pro Ser Val Ala Gln Phe Val Leu 
        755                 760                 765             


Xaa Pro Ser Xaa Glu Val Cys Ser Pro Arg Tyr His Arg Asp Ala Asn 
    770                 775                 780                 


Xaa Ala Leu Pro Leu Ala Leu Arg Xaa Val Ser Arg Leu Val Glu Arg 
785                 790                 795                 800 


Glu Ala Gly Leu Met Pro Gly 
                805         


<210> 2490
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<400> 2490
Met Asp Ala Lys Ala Arg Asn Cys Leu Leu Gln His Arg Glu Ala Leu 
1               5                   10                  15      


Glu Lys Asp Ile Lys Xaa Ser Tyr Ile Met Asp His Met Ile Ser Asp 
            20                  25                  30          


Gly Phe Leu Xaa Ile Ser Glu Glu Glu Lys Val Arg Asn Glu Pro Xaa 
        35                  40                  45              


Gln Gln Gln Arg Ala Ala Met Leu Ile Lys Met Ile Leu Lys Lys Asp 
    50                  55                  60                  


Asn Asp Ser Tyr Val Ser Phe Tyr Asn Ala Leu Leu His Glu Gly Tyr 
65                  70                  75                  80  


Lys Asp Leu Ala Ala Leu Leu His Asp Gly Ile Pro Val Val Ser Ser 
                85                  90                  95      


Ser Ser Gly Lys Asp Ser Val Ser Gly Ile Xaa Ser Tyr Gly Leu Tyr 
            100                 105                 110         


Pro Leu Tyr Leu Leu Ser Leu Cys Tyr Gln Asn Cys Phe Gly Phe Val 
        115                 120                 125             


Leu Leu 
    130 


<210> 2491
<211> 338
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<400> 2491
Met Asp Ala Lys Ala Arg Asn Cys Leu Leu Gln His Arg Glu Ala Leu 
1               5                   10                  15      


Glu Lys Asp Ile Lys Xaa Ser Tyr Ile Met Asp His Met Ile Ser Asp 
            20                  25                  30          


Gly Phe Leu Xaa Ile Ser Glu Glu Glu Lys Val Arg Asn Glu Pro Xaa 
        35                  40                  45              


Gln Gln Gln Arg Ala Ala Met Leu Ile Lys Met Ile Leu Lys Lys Asp 
    50                  55                  60                  


Asn Asp Ser Tyr Val Ser Phe Tyr Asn Ala Leu Leu His Glu Gly Tyr 
65                  70                  75                  80  


Lys Asp Leu Ala Ala Leu Leu His Asp Gly Ile Pro Val Val Ser Ser 
                85                  90                  95      


Ser Ser Gly Lys Asp Ser Val Ser Gly Ile Xaa Ser Tyr Val Arg Xaa 
            100                 105                 110         


Val Leu Cys Glu Gly Gly Val Pro Gln Arg Pro Val Val Phe Val Xaa 
        115                 120                 125             


Arg Lys Lys Leu Val Asn Ala Ile Gln Gln Lys Leu Ser Lys Leu Lys 
    130                 135                 140                 


Gly Glu Pro Gly Trp Val Xaa Ile His Gly Met Ala Gly Cys Gly Lys 
145                 150                 155                 160 


Ser Val Leu Ala Ala Glu Ala Val Arg Asp His Ser Leu Leu Glu Gly 
                165                 170                 175     


Cys Phe Pro Gly Gly Val His Trp Val Ser Val Gly Lys Gln Asp Lys 
            180                 185                 190         


Ser Gly Leu Leu Met Lys Leu Gln Asn Leu Cys Xaa Arg Leu Asp Gln 
        195                 200                 205             


Asp Glu Ser Phe Ser Gln Arg Leu Pro Leu Asn Ile Glu Glu Ala Lys 
    210                 215                 220                 


Asp Arg Leu Arg Ile Leu Met Leu Arg Lys His Pro Arg Ser Leu Leu 
225                 230                 235                 240 


Ile Leu Asp Asp Val Trp Asp Ser Trp Val Leu Lys Ala Phe Asp Ser 
                245                 250                 255     


Gln Cys Gln Ile Leu Leu Xaa Xaa Arg Asp Lys Ser Val Xaa Asp Ser 
            260                 265                 270         


Val Met Gly Pro Lys Tyr Val Val Pro Val Glu Ser Ser Leu Gly Lys 
        275                 280                 285             


Glu Lys Gly Leu Glu Ile Leu Ser Leu Phe Val Asn Met Lys Lys Ala 
    290                 295                 300                 


Asp Leu Pro Glu Gln Ala His Ser Ile Ile Lys Glu Cys Lys Val Val 
305                 310                 315                 320 


Glu Arg Cys His Trp Gly Ile Leu Xaa Asp Leu Leu His Lys Trp Asn 
                325                 330                 335     


Gln Ser 
        


<210> 2492
<211> 1163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1161)..(1161)
<223> Selenocysteine

<400> 2492
Met Asp Ala Lys Ala Arg Asn Cys Leu Leu Gln His Arg Glu Ala Leu 
1               5                   10                  15      


Glu Lys Asp Ile Lys Xaa Ser Tyr Ile Met Asp His Met Ile Ser Asp 
            20                  25                  30          


Gly Phe Leu Xaa Ile Ser Glu Glu Glu Lys Val Arg Asn Glu Pro Xaa 
        35                  40                  45              


Gln Gln Gln Arg Ala Ala Met Leu Ile Lys Met Ile Leu Lys Lys Asp 
    50                  55                  60                  


Asn Asp Ser Tyr Val Ser Phe Tyr Asn Ala Leu Leu His Glu Gly Tyr 
65                  70                  75                  80  


Lys Asp Leu Ala Ala Leu Leu His Asp Gly Ile Pro Val Val Ser Ser 
                85                  90                  95      


Ser Ser Gly Lys Asp Ser Val Ser Gly Ile Xaa Ser Tyr Val Arg Xaa 
            100                 105                 110         


Val Leu Cys Glu Gly Gly Val Pro Gln Arg Pro Val Val Phe Val Xaa 
        115                 120                 125             


Arg Lys Lys Leu Val Asn Ala Ile Gln Gln Lys Leu Ser Lys Leu Lys 
    130                 135                 140                 


Gly Glu Pro Gly Trp Val Xaa Ile His Gly Met Ala Gly Cys Gly Lys 
145                 150                 155                 160 


Ser Val Leu Ala Ala Glu Ala Val Arg Asp His Ser Leu Leu Glu Gly 
                165                 170                 175     


Cys Phe Pro Gly Gly Val His Trp Val Ser Val Gly Lys Gln Asp Lys 
            180                 185                 190         


Ser Gly Leu Leu Met Lys Leu Gln Asn Leu Cys Xaa Arg Leu Asp Gln 
        195                 200                 205             


Asp Glu Ser Phe Ser Gln Arg Leu Pro Leu Asn Ile Glu Glu Ala Lys 
    210                 215                 220                 


Asp Arg Leu Arg Ile Leu Met Leu Arg Lys His Pro Arg Ser Leu Leu 
225                 230                 235                 240 


Ile Leu Asp Asp Val Trp Asp Ser Trp Val Leu Lys Ala Phe Asp Ser 
                245                 250                 255     


Gln Cys Gln Ile Leu Leu Xaa Xaa Arg Asp Lys Ser Val Xaa Asp Ser 
            260                 265                 270         


Val Met Gly Pro Lys Tyr Val Val Pro Val Glu Ser Ser Leu Gly Lys 
        275                 280                 285             


Glu Lys Gly Leu Glu Ile Leu Ser Leu Phe Val Asn Met Lys Lys Ala 
    290                 295                 300                 


Asp Leu Pro Glu Gln Ala His Ser Ile Ile Lys Glu Cys Lys Gly Ser 
305                 310                 315                 320 


Pro Leu Val Val Ser Leu Ile Gly Ala Leu Leu Arg Asp Phe Pro Asn 
                325                 330                 335     


Arg Trp Glu Tyr Tyr Leu Lys Gln Leu Gln Asn Lys Gln Phe Lys Arg 
            340                 345                 350         


Ile Arg Lys Ser Ser Ser Tyr Asp Tyr Glu Ala Leu Asp Glu Ala Met 
        355                 360                 365             


Ser Ile Ser Val Glu Met Leu Arg Glu Asp Ile Lys Asp Tyr Tyr Xaa 
    370                 375                 380                 


Asp Leu Ser Ile Leu Gln Lys Asp Val Lys Val Pro Xaa Lys Val Leu 
385                 390                 395                 400 


Cys Ile Leu Trp Asp Met Glu Xaa Glu Glu Val Glu Asp Ile Leu Gln 
                405                 410                 415     


Glu Phe Val Asn Lys Ser Leu Leu Phe Cys Asp Arg Asn Gly Lys Ser 
            420                 425                 430         


Phe Arg Tyr Tyr Leu His Asp Leu Gln Val Asp Phe Leu Xaa Glu Lys 
        435                 440                 445             


Asn Cys Ser Gln Leu Gln Asp Leu His Lys Lys Ile Ile Xaa Gln Phe 
    450                 455                 460                 


Gln Arg Tyr His Gln Pro His Xaa Leu Ser Pro Asp Gln Glu Asp Cys 
465                 470                 475                 480 


Met Tyr Trp Tyr Asn Phe Leu Ala Tyr His Met Ala Ser Ala Lys Met 
                485                 490                 495     


His Lys Glu Leu Cys Ala Leu Met Phe Ser Leu Asp Trp Ile Lys Ala 
            500                 505                 510         


Lys Xaa Glu Leu Val Gly Pro Ala His Leu Ile His Glu Phe Val Glu 
        515                 520                 525             


Tyr Arg His Ile Leu Asp Glu Lys Asp Cys Ala Val Ser Glu Asn Phe 
    530                 535                 540                 


Gln Glu Phe Leu Ser Leu Asn Gly His Leu Leu Gly Arg Gln Pro Phe 
545                 550                 555                 560 


Pro Asn Ile Val Gln Leu Gly Leu Cys Glu Pro Glu Xaa Ser Glu Val 
                565                 570                 575     


Tyr Gln Gln Ala Lys Leu Gln Ala Lys Gln Glu Val Asp Asn Gly Met 
            580                 585                 590         


Leu Tyr Leu Glu Trp Ile Asn Lys Lys Asn Ile Xaa Asn Leu Ser Arg 
        595                 600                 605             


Leu Val Val Arg Pro His Xaa Asp Ala Val Tyr His Ala Cys Phe Ser 
    610                 615                 620                 


Glu Asp Gly Gln Arg Ile Ala Ser Cys Gly Ala Asp Lys Xaa Leu Gln 
625                 630                 635                 640 


Val Phe Lys Ala Glu Xaa Gly Glu Lys Leu Leu Glu Ile Lys Ala His 
                645                 650                 655     


Glu Asp Glu Val Leu Cys Cys Ala Phe Ser Xaa Asp Asp Arg Phe Ile 
            660                 665                 670         


Ala Xaa Cys Ser Val Asp Lys Lys Val Lys Ile Trp Asn Ser Met Xaa 
        675                 680                 685             


Gly Glu Leu Val His Xaa Tyr Asp Glu His Ser Glu Gln Val Asn Cys 
    690                 695                 700                 


Cys His Phe Xaa Asn Ser Ser His His Leu Leu Leu Ala Xaa Gly Ser 
705                 710                 715                 720 


Ser Asp Cys Phe Leu Lys Leu Trp Asp Leu Asn Gln Lys Glu Cys Arg 
                725                 730                 735     


Asn Xaa Met Phe Gly His Xaa Asn Ser Val Asn His Cys Arg Phe Ser 
            740                 745                 750         


Pro Asp Asp Lys Leu Leu Ala Ser Cys Ser Ala Asp Gly Xaa Leu Lys 
        755                 760                 765             


Leu Trp Asp Ala Xaa Ser Ala Asn Glu Arg Lys Ser Ile Asn Val Lys 
    770                 775                 780                 


Gln Phe Phe Leu Asn Leu Glu Asp Pro Gln Glu Asp Met Glu Val Ile 
785                 790                 795                 800 


Val Lys Cys Cys Ser Trp Ser Ala Asp Gly Ala Arg Ile Met Val Ala 
                805                 810                 815     


Ala Lys Asn Lys Ile Phe Leu Trp Asn Xaa Asp Ser Arg Ser Lys Val 
            820                 825                 830         


Ala Asp Cys Arg Gly His Leu Ser Trp Val His Gly Val Met Phe Ser 
        835                 840                 845             


Pro Asp Gly Ser Ser Phe Leu Xaa Ser Ser Asp Asp Gln Xaa Ile Arg 
    850                 855                 860                 


Leu Trp Glu Xaa Lys Lys Val Cys Lys Asn Ser Ala Val Met Leu Lys 
865                 870                 875                 880 


Gln Glu Val Asp Val Val Phe Gln Glu Asn Glu Val Met Val Leu Ala 
                885                 890                 895     


Val Asp His Ile Arg Arg Leu Gln Leu Ile Asn Gly Arg Xaa Gly Gln 
            900                 905                 910         


Ile Asp Tyr Leu Xaa Glu Ala Gln Val Ser Cys Cys Cys Leu Ser Pro 
        915                 920                 925             


His Leu Gln Tyr Ile Ala Phe Gly Asp Glu Asn Gly Ala Ile Glu Ile 
    930                 935                 940                 


Leu Glu Leu Val Asn Asn Arg Ile Phe Gln Ser Arg Phe Gln His Lys 
945                 950                 955                 960 


Lys Xaa Val Trp His Ile Gln Phe Xaa Ala Asp Glu Lys Xaa Leu Ile 
                965                 970                 975     


Ser Ser Ser Asp Asp Ala Glu Ile Gln Val Trp Asn Trp Gln Leu Asp 
            980                 985                 990         


Lys Cys Ile Phe Leu Arg Gly His  Gln Glu Xaa Val Lys  Asp Phe Arg 
        995                 1000                 1005             


Leu Leu  Lys Asn Ser Arg Leu  Leu Ser Trp Ser Phe  Asp Gly Xaa 
    1010                 1015                 1020             


Val Lys  Val Trp Asn Ile Ile  Xaa Gly Asn Lys Glu  Lys Asp Phe 
    1025                 1030                 1035             


Val Cys  His Gln Gly Xaa Val  Leu Ser Cys Asp Ile  Ser His Asp 
    1040                 1045                 1050             


Ala Xaa  Lys Phe Ser Ser Xaa  Ser Ala Asp Lys Xaa  Ala Lys Ile 
    1055                 1060                 1065             


Trp Asn  Val Ser Asn Gly Glu  Leu Leu His Leu Cys  Ala Pro Leu 
    1070                 1075                 1080             


Ser Glu  Glu Gly Ala Ala Xaa  His Gly Gly Trp Val  Xaa Asp Leu 
    1085                 1090                 1095             


Cys Phe  Ser Pro Asp Gly Lys  Met Leu Ile Ser Ala  Gly Gly Tyr 
    1100                 1105                 1110             


Ile Lys  Trp Trp Asn Val Val  Xaa Gly Glu Ser Ser  Gln Xaa Phe 
    1115                 1120                 1125             


Tyr Xaa  Asn Gly Xaa Asn Leu  Lys Lys Ile His Val  Ser Pro Asp 
    1130                 1135                 1140             


Phe Lys  Xaa Tyr Val Xaa Val  Asp Asn Leu Gly Ile  Leu Tyr Ile 
    1145                 1150                 1155             


Leu Gln  Xaa Leu Glu 
    1160             


<210> 2493
<211> 1205
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1138)..(1138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1191)..(1191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<400> 2493
Met Asp Ala Lys Ala Arg Asn Cys Leu Leu Gln His Arg Glu Ala Leu 
1               5                   10                  15      


Glu Lys Asp Ile Lys Xaa Ser Tyr Ile Met Asp His Met Ile Ser Asp 
            20                  25                  30          


Gly Phe Leu Xaa Ile Ser Glu Glu Glu Lys Val Arg Asn Glu Pro Xaa 
        35                  40                  45              


Gln Gln Gln Arg Ala Ala Met Leu Ile Lys Met Ile Leu Lys Lys Asp 
    50                  55                  60                  


Asn Asp Ser Tyr Val Ser Phe Tyr Asn Ala Leu Leu His Glu Gly Tyr 
65                  70                  75                  80  


Lys Asp Leu Ala Ala Leu Leu His Asp Gly Ile Pro Val Val Ser Ser 
                85                  90                  95      


Ser Ser Gly Lys Asp Ser Val Ser Gly Ile Xaa Ser Tyr Val Arg Xaa 
            100                 105                 110         


Val Leu Cys Glu Gly Gly Val Pro Gln Arg Pro Val Val Phe Val Xaa 
        115                 120                 125             


Arg Lys Lys Leu Val Asn Ala Ile Gln Gln Lys Leu Ser Lys Leu Lys 
    130                 135                 140                 


Gly Glu Pro Gly Trp Val Xaa Ile His Gly Met Ala Gly Cys Gly Lys 
145                 150                 155                 160 


Ser Val Leu Ala Ala Glu Ala Val Arg Asp His Ser Leu Leu Glu Gly 
                165                 170                 175     


Cys Phe Pro Gly Gly Val His Trp Val Ser Val Gly Lys Gln Asp Lys 
            180                 185                 190         


Ser Gly Leu Leu Met Lys Leu Gln Asn Leu Cys Xaa Arg Leu Asp Gln 
        195                 200                 205             


Asp Glu Ser Phe Ser Gln Arg Leu Pro Leu Asn Ile Glu Glu Ala Lys 
    210                 215                 220                 


Asp Arg Leu Arg Ile Leu Met Leu Arg Lys His Pro Arg Ser Leu Leu 
225                 230                 235                 240 


Ile Leu Asp Asp Val Trp Asp Ser Trp Val Leu Lys Ala Phe Asp Ser 
                245                 250                 255     


Gln Cys Gln Ile Leu Leu Xaa Xaa Arg Asp Lys Ser Val Xaa Asp Ser 
            260                 265                 270         


Val Met Gly Pro Lys Tyr Val Val Pro Val Glu Ser Ser Leu Gly Lys 
        275                 280                 285             


Glu Lys Gly Leu Glu Ile Leu Ser Leu Phe Val Asn Met Lys Lys Ala 
    290                 295                 300                 


Asp Leu Pro Glu Gln Ala His Ser Ile Ile Lys Glu Cys Lys Gly Ser 
305                 310                 315                 320 


Pro Leu Val Val Ser Leu Ile Gly Ala Leu Leu Arg Asp Phe Pro Asn 
                325                 330                 335     


Arg Trp Glu Tyr Tyr Leu Lys Gln Leu Gln Asn Lys Gln Phe Lys Arg 
            340                 345                 350         


Ile Arg Lys Ser Ser Ser Tyr Asp Tyr Glu Ala Leu Asp Glu Ala Met 
        355                 360                 365             


Ser Ile Ser Val Glu Met Leu Arg Glu Asp Ile Lys Asp Tyr Tyr Xaa 
    370                 375                 380                 


Asp Leu Ser Ile Leu Gln Lys Asp Val Lys Val Pro Xaa Lys Val Leu 
385                 390                 395                 400 


Cys Ile Leu Trp Asp Met Glu Xaa Glu Glu Val Glu Asp Ile Leu Gln 
                405                 410                 415     


Glu Phe Val Asn Lys Ser Leu Leu Phe Cys Asp Arg Asn Gly Lys Ser 
            420                 425                 430         


Phe Arg Tyr Tyr Leu His Asp Leu Gln Val Asp Phe Leu Xaa Glu Lys 
        435                 440                 445             


Asn Cys Ser Gln Leu Gln Asp Leu His Lys Lys Ile Ile Xaa Gln Phe 
    450                 455                 460                 


Gln Arg Tyr His Gln Pro His Xaa Leu Ser Pro Asp Gln Glu Asp Cys 
465                 470                 475                 480 


Met Tyr Trp Tyr Asn Phe Leu Ala Tyr His Met Ala Ser Ala Lys Met 
                485                 490                 495     


His Lys Glu Leu Cys Ala Leu Met Phe Ser Leu Asp Trp Ile Lys Ala 
            500                 505                 510         


Lys Xaa Glu Leu Val Gly Pro Ala His Leu Ile His Glu Phe Val Glu 
        515                 520                 525             


Tyr Arg His Ile Leu Asp Glu Lys Asp Cys Ala Val Ser Glu Asn Phe 
    530                 535                 540                 


Gln Glu Phe Leu Ser Leu Asn Gly His Leu Leu Gly Arg Gln Pro Phe 
545                 550                 555                 560 


Pro Asn Ile Val Gln Leu Gly Leu Cys Glu Pro Glu Xaa Ser Glu Val 
                565                 570                 575     


Tyr Gln Gln Ala Lys Leu Gln Ala Lys Gln Glu Val Asp Asn Gly Met 
            580                 585                 590         


Leu Tyr Leu Glu Trp Ile Asn Lys Lys Asn Ile Xaa Asn Leu Ser Arg 
        595                 600                 605             


Leu Val Val Arg Pro His Xaa Asp Ala Val Tyr His Ala Cys Phe Ser 
    610                 615                 620                 


Glu Asp Gly Gln Arg Ile Ala Ser Cys Gly Ala Asp Lys Xaa Leu Gln 
625                 630                 635                 640 


Val Phe Lys Ala Glu Xaa Gly Glu Lys Leu Leu Glu Ile Lys Ala His 
                645                 650                 655     


Glu Asp Glu Val Leu Cys Cys Ala Phe Ser Xaa Asp Asp Arg Phe Ile 
            660                 665                 670         


Ala Xaa Cys Ser Val Asp Lys Lys Val Lys Ile Trp Asn Ser Met Xaa 
        675                 680                 685             


Gly Glu Leu Val His Xaa Tyr Asp Glu His Ser Glu Gln Val Asn Cys 
    690                 695                 700                 


Cys His Phe Xaa Asn Ser Ser His His Leu Leu Leu Ala Xaa Gly Ser 
705                 710                 715                 720 


Ser Asp Cys Phe Leu Lys Leu Trp Asp Leu Asn Gln Lys Glu Cys Arg 
                725                 730                 735     


Asn Xaa Met Phe Gly His Xaa Asn Ser Val Asn His Cys Arg Phe Ser 
            740                 745                 750         


Pro Asp Asp Lys Leu Leu Ala Ser Cys Ser Ala Asp Gly Xaa Leu Lys 
        755                 760                 765             


Leu Trp Asp Ala Xaa Ser Ala Asn Glu Arg Lys Ser Ile Asn Val Lys 
    770                 775                 780                 


Gln Phe Phe Leu Asn Leu Glu Asp Pro Gln Glu Asp Met Glu Val Ile 
785                 790                 795                 800 


Val Lys Cys Cys Ser Trp Ser Ala Asp Gly Ala Arg Ile Met Val Ala 
                805                 810                 815     


Ala Lys Asn Lys Ile Phe Leu Trp Asn Xaa Asp Ser Arg Ser Lys Val 
            820                 825                 830         


Ala Asp Cys Arg Gly His Leu Ser Trp Val His Gly Val Met Phe Ser 
        835                 840                 845             


Pro Asp Gly Ser Ser Phe Leu Xaa Ser Ser Asp Asp Gln Xaa Ile Arg 
    850                 855                 860                 


Leu Trp Glu Xaa Lys Lys Val Cys Lys Asn Ser Ala Val Met Leu Lys 
865                 870                 875                 880 


Gln Glu Val Asp Val Val Phe Gln Glu Asn Glu Val Met Val Leu Ala 
                885                 890                 895     


Val Asp His Ile Arg Arg Leu Gln Leu Ile Asn Gly Arg Xaa Gly Gln 
            900                 905                 910         


Ile Asp Tyr Leu Xaa Glu Ala Gln Val Ser Cys Cys Cys Leu Ser Pro 
        915                 920                 925             


His Leu Gln Tyr Ile Ala Phe Gly Asp Glu Asn Gly Ala Ile Glu Ile 
    930                 935                 940                 


Leu Glu Leu Val Asn Asn Arg Ile Phe Gln Ser Arg Phe Gln His Lys 
945                 950                 955                 960 


Lys Xaa Val Trp His Ile Gln Phe Xaa Ala Asp Glu Lys Xaa Leu Ile 
                965                 970                 975     


Ser Ser Ser Asp Asp Ala Glu Ile Gln Val Trp Asn Trp Gln Leu Asp 
            980                 985                 990         


Lys Cys Ile Phe Leu Arg Gly His  Gln Glu Xaa Val Lys  Asp Phe Arg 
        995                 1000                 1005             


Leu Leu  Lys Asn Ser Arg Leu  Leu Ser Trp Ser Phe  Asp Gly Xaa 
    1010                 1015                 1020             


Val Lys  Val Trp Asn Ile Ile  Xaa Gly Asn Lys Glu  Lys Asp Phe 
    1025                 1030                 1035             


Val Cys  His Gln Gly Xaa Val  Leu Ser Cys Asp Ile  Ser His Asp 
    1040                 1045                 1050             


Ala Xaa  Lys Phe Ser Ser Xaa  Ser Ala Asp Lys Xaa  Ala Lys Ile 
    1055                 1060                 1065             


Trp Ser  Phe Asp Leu Leu Leu  Pro Leu His Glu Leu  Arg Gly His 
    1070                 1075                 1080             


Asn Gly  Cys Val Arg Cys Ser  Ala Phe Ser Val Asp  Ser Xaa Leu 
    1085                 1090                 1095             


Leu Ala  Xaa Gly Asp Asp Asn  Gly Glu Ile Arg Ile  Trp Asn Val 
    1100                 1105                 1110             


Ser Asn  Gly Glu Leu Leu His  Leu Cys Ala Pro Leu  Ser Glu Glu 
    1115                 1120                 1125             


Gly Ala  Ala Xaa His Gly Gly  Trp Val Xaa Asp Leu  Cys Phe Ser 
    1130                 1135                 1140             


Pro Asp  Gly Lys Met Leu Ile  Ser Ala Gly Gly Tyr  Ile Lys Trp 
    1145                 1150                 1155             


Trp Asn  Val Val Xaa Gly Glu  Ser Ser Gln Xaa Phe  Tyr Xaa Asn 
    1160                 1165                 1170             


Gly Xaa  Asn Leu Lys Lys Ile  His Val Ser Pro Asp  Phe Lys Xaa 
    1175                 1180                 1185             


Tyr Val  Xaa Val Asp Asn Leu  Gly Ile Leu Tyr Ile  Leu Gln Xaa 
    1190                 1195                 1200             


Leu Glu  
    1205 


<210> 2494
<211> 1248
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1017)..(1017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1066)..(1066)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1103)..(1103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1108)..(1108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1206)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1218)..(1218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1234)..(1234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1246)..(1246)
<223> Selenocysteine

<400> 2494
Met Asp Ala Lys Ala Arg Asn Cys Leu Leu Gln His Arg Glu Ala Leu 
1               5                   10                  15      


Glu Lys Asp Ile Lys Xaa Ser Tyr Ile Met Asp His Met Ile Ser Asp 
            20                  25                  30          


Gly Phe Leu Xaa Ile Ser Glu Glu Glu Lys Val Arg Asn Glu Pro Xaa 
        35                  40                  45              


Gln Gln Gln Arg Ala Ala Met Leu Ile Lys Met Ile Leu Lys Lys Asp 
    50                  55                  60                  


Asn Asp Ser Tyr Val Ser Phe Tyr Asn Ala Leu Leu His Glu Gly Tyr 
65                  70                  75                  80  


Lys Asp Leu Ala Ala Leu Leu His Asp Gly Ile Pro Val Val Ser Ser 
                85                  90                  95      


Ser Ser Gly Lys Asp Ser Val Ser Gly Ile Xaa Ser Tyr Val Arg Xaa 
            100                 105                 110         


Val Leu Cys Glu Gly Gly Val Pro Gln Arg Pro Val Val Phe Val Xaa 
        115                 120                 125             


Arg Lys Lys Leu Val Asn Ala Ile Gln Gln Lys Leu Ser Lys Leu Lys 
    130                 135                 140                 


Gly Glu Pro Gly Trp Val Xaa Ile His Gly Met Ala Gly Cys Gly Lys 
145                 150                 155                 160 


Ser Val Leu Ala Ala Glu Ala Val Arg Asp His Ser Leu Leu Glu Gly 
                165                 170                 175     


Cys Phe Pro Gly Gly Val His Trp Val Ser Val Gly Lys Gln Asp Lys 
            180                 185                 190         


Ser Gly Leu Leu Met Lys Leu Gln Asn Leu Cys Xaa Arg Leu Asp Gln 
        195                 200                 205             


Asp Glu Ser Phe Ser Gln Arg Leu Pro Leu Asn Ile Glu Glu Ala Lys 
    210                 215                 220                 


Asp Arg Leu Arg Ile Leu Met Leu Arg Lys His Pro Arg Ser Leu Leu 
225                 230                 235                 240 


Ile Leu Asp Asp Val Trp Asp Ser Trp Val Leu Lys Ala Phe Asp Ser 
                245                 250                 255     


Gln Cys Gln Ile Leu Leu Xaa Xaa Arg Asp Lys Ser Val Xaa Asp Ser 
            260                 265                 270         


Val Met Gly Pro Lys Tyr Val Val Pro Val Glu Ser Ser Leu Gly Lys 
        275                 280                 285             


Glu Lys Gly Leu Glu Ile Leu Ser Leu Phe Val Asn Met Lys Lys Ala 
    290                 295                 300                 


Asp Leu Pro Glu Gln Ala His Ser Ile Ile Lys Glu Cys Lys Gly Ser 
305                 310                 315                 320 


Pro Leu Val Val Ser Leu Ile Gly Ala Leu Leu Arg Asp Phe Pro Asn 
                325                 330                 335     


Arg Trp Glu Tyr Tyr Leu Lys Gln Leu Gln Asn Lys Gln Phe Lys Arg 
            340                 345                 350         


Ile Arg Lys Ser Ser Ser Tyr Asp Tyr Glu Ala Leu Asp Glu Ala Met 
        355                 360                 365             


Ser Ile Ser Val Glu Met Leu Arg Glu Asp Ile Lys Asp Tyr Tyr Xaa 
    370                 375                 380                 


Asp Leu Ser Ile Leu Gln Lys Asp Val Lys Val Pro Xaa Lys Val Leu 
385                 390                 395                 400 


Cys Ile Leu Trp Asp Met Glu Xaa Glu Glu Val Glu Asp Ile Leu Gln 
                405                 410                 415     


Glu Phe Val Asn Lys Ser Leu Leu Phe Cys Asp Arg Asn Gly Lys Ser 
            420                 425                 430         


Phe Arg Tyr Tyr Leu His Asp Leu Gln Val Asp Phe Leu Xaa Glu Lys 
        435                 440                 445             


Asn Cys Ser Gln Leu Gln Asp Leu His Lys Lys Ile Ile Xaa Gln Phe 
    450                 455                 460                 


Gln Arg Tyr His Gln Pro His Xaa Leu Ser Pro Asp Gln Glu Asp Cys 
465                 470                 475                 480 


Met Tyr Trp Tyr Asn Phe Leu Ala Tyr His Met Ala Ser Ala Lys Met 
                485                 490                 495     


His Lys Glu Leu Cys Ala Leu Met Phe Ser Leu Asp Trp Ile Lys Ala 
            500                 505                 510         


Lys Xaa Glu Leu Val Gly Pro Ala His Leu Ile His Glu Phe Val Glu 
        515                 520                 525             


Tyr Arg His Ile Leu Asp Glu Lys Asp Cys Ala Val Ser Glu Asn Phe 
    530                 535                 540                 


Gln Glu Phe Leu Ser Leu Asn Gly His Leu Leu Gly Arg Gln Pro Phe 
545                 550                 555                 560 


Pro Asn Ile Val Gln Leu Gly Leu Cys Glu Pro Glu Xaa Ser Glu Val 
                565                 570                 575     


Tyr Gln Gln Ala Lys Leu Gln Ala Lys Gln Glu Val Asp Asn Gly Met 
            580                 585                 590         


Leu Tyr Leu Glu Trp Ile Asn Lys Lys Asn Ile Xaa Asn Leu Ser Arg 
        595                 600                 605             


Leu Val Val Arg Pro His Xaa Asp Ala Val Tyr His Ala Cys Phe Ser 
    610                 615                 620                 


Glu Asp Gly Gln Arg Ile Ala Ser Cys Gly Ala Asp Lys Xaa Leu Gln 
625                 630                 635                 640 


Val Phe Lys Ala Glu Xaa Gly Glu Lys Leu Leu Glu Ile Lys Ala His 
                645                 650                 655     


Glu Asp Glu Val Leu Cys Cys Ala Phe Ser Xaa Asp Asp Arg Phe Ile 
            660                 665                 670         


Ala Xaa Cys Ser Val Asp Lys Lys Val Lys Ile Trp Asn Ser Met Xaa 
        675                 680                 685             


Gly Glu Leu Val His Xaa Tyr Asp Glu His Ser Glu Gln Val Asn Cys 
    690                 695                 700                 


Cys His Phe Xaa Asn Ser Ser His His Leu Leu Leu Ala Xaa Gly Ser 
705                 710                 715                 720 


Ser Asp Cys Phe Leu Lys Leu Trp Asp Leu Asn Gln Lys Glu Cys Arg 
                725                 730                 735     


Asn Xaa Met Phe Gly His Xaa Asn Ser Val Asn His Cys Arg Phe Ser 
            740                 745                 750         


Pro Asp Asp Lys Leu Leu Ala Ser Cys Ser Ala Asp Gly Xaa Leu Lys 
        755                 760                 765             


Leu Trp Asp Ala Xaa Ser Ala Asn Glu Arg Lys Ser Ile Asn Val Lys 
    770                 775                 780                 


Gln Phe Phe Leu Asn Leu Glu Asp Pro Gln Glu Asp Met Glu Val Ile 
785                 790                 795                 800 


Val Lys Cys Cys Ser Trp Ser Ala Asp Gly Ala Arg Ile Met Val Ala 
                805                 810                 815     


Ala Lys Asn Lys Ile Phe Leu Phe Asp Ile His Xaa Ser Gly Leu Leu 
            820                 825                 830         


Gly Glu Ile His Xaa Gly His His Ser Xaa Ile Gln Tyr Cys Asp Phe 
        835                 840                 845             


Ser Pro Gln Asn His Leu Ala Val Val Ala Leu Ser Gln Tyr Cys Val 
    850                 855                 860                 


Glu Leu Trp Asn Xaa Asp Ser Arg Ser Lys Val Ala Asp Cys Arg Gly 
865                 870                 875                 880 


His Leu Ser Trp Val His Gly Val Met Phe Ser Pro Asp Gly Ser Ser 
                885                 890                 895     


Phe Leu Xaa Ser Ser Asp Asp Gln Xaa Ile Arg Leu Trp Glu Xaa Lys 
            900                 905                 910         


Lys Val Cys Lys Asn Ser Ala Val Met Leu Lys Gln Glu Val Asp Val 
        915                 920                 925             


Val Phe Gln Glu Asn Glu Val Met Val Leu Ala Val Asp His Ile Arg 
    930                 935                 940                 


Arg Leu Gln Leu Ile Asn Gly Arg Xaa Gly Gln Ile Asp Tyr Leu Xaa 
945                 950                 955                 960 


Glu Ala Gln Val Ser Cys Cys Cys Leu Ser Pro His Leu Gln Tyr Ile 
                965                 970                 975     


Ala Phe Gly Asp Glu Asn Gly Ala Ile Glu Ile Leu Glu Leu Val Asn 
            980                 985                 990         


Asn Arg Ile Phe Gln Ser Arg Phe  Gln His Lys Lys Xaa  Val Trp His 
        995                 1000                 1005             


Ile Gln  Phe Xaa Ala Asp Glu  Lys Xaa Leu Ile Ser  Ser Ser Asp 
    1010                 1015                 1020             


Asp Ala  Glu Ile Gln Val Trp  Asn Trp Gln Leu Asp  Lys Cys Ile 
    1025                 1030                 1035             


Phe Leu  Arg Gly His Gln Glu  Xaa Val Lys Asp Phe  Arg Leu Leu 
    1040                 1045                 1050             


Lys Asn  Ser Arg Leu Leu Ser  Trp Ser Phe Asp Gly  Xaa Val Lys 
    1055                 1060                 1065             


Val Trp  Asn Ile Ile Xaa Gly  Asn Lys Glu Lys Asp  Phe Val Cys 
    1070                 1075                 1080             


His Gln  Gly Xaa Val Leu Ser  Cys Asp Ile Ser His  Asp Ala Xaa 
    1085                 1090                 1095             


Lys Phe  Ser Ser Xaa Ser Ala  Asp Lys Xaa Ala Lys  Ile Trp Ser 
    1100                 1105                 1110             


Phe Asp  Leu Leu Leu Pro Leu  His Glu Leu Arg Gly  His Asn Gly 
    1115                 1120                 1125             


Cys Val  Arg Cys Ser Ala Phe  Ser Val Asp Ser Xaa  Leu Leu Ala 
    1130                 1135                 1140             


Xaa Gly  Asp Asp Asn Gly Glu  Ile Arg Ile Trp Asn  Val Ser Asn 
    1145                 1150                 1155             


Gly Glu  Leu Leu His Leu Cys  Ala Pro Leu Ser Glu  Glu Gly Ala 
    1160                 1165                 1170             


Ala Xaa  His Gly Gly Trp Val  Xaa Asp Leu Cys Phe  Ser Pro Asp 
    1175                 1180                 1185             


Gly Lys  Met Leu Ile Ser Ala  Gly Gly Tyr Ile Lys  Trp Trp Asn 
    1190                 1195                 1200             


Val Val  Xaa Gly Glu Ser Ser  Gln Xaa Phe Tyr Xaa  Asn Gly Xaa 
    1205                 1210                 1215             


Asn Leu  Lys Lys Ile His Val  Ser Pro Asp Phe Lys  Xaa Tyr Val 
    1220                 1225                 1230             


Xaa Val  Asp Asn Leu Gly Ile  Leu Tyr Ile Leu Gln  Xaa Leu Glu 
    1235                 1240                 1245             


<210> 2495
<211> 1194
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1152)..(1152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1161)..(1161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<400> 2495
Met Asp Ala Lys Ala Arg Asn Cys Leu Leu Gln His Arg Glu Ala Leu 
1               5                   10                  15      


Glu Lys Asp Ile Lys Xaa Ser Tyr Ile Met Asp His Met Ile Ser Asp 
            20                  25                  30          


Gly Phe Leu Xaa Ile Ser Glu Glu Glu Lys Val Arg Asn Glu Pro Xaa 
        35                  40                  45              


Gln Gln Gln Arg Ala Ala Met Leu Ile Lys Met Ile Leu Lys Lys Asp 
    50                  55                  60                  


Asn Asp Ser Tyr Val Ser Phe Tyr Asn Ala Leu Leu His Glu Gly Tyr 
65                  70                  75                  80  


Lys Asp Leu Ala Ala Leu Leu His Asp Gly Ile Pro Val Val Ser Ser 
                85                  90                  95      


Ser Ser Val Arg Xaa Val Leu Cys Glu Gly Gly Val Pro Gln Arg Pro 
            100                 105                 110         


Val Val Phe Val Xaa Arg Lys Lys Leu Val Asn Ala Ile Gln Gln Lys 
        115                 120                 125             


Leu Ser Lys Leu Lys Gly Glu Pro Gly Trp Val Xaa Ile His Gly Met 
    130                 135                 140                 


Ala Gly Cys Gly Lys Ser Val Leu Ala Ala Glu Ala Val Arg Asp His 
145                 150                 155                 160 


Ser Leu Leu Glu Gly Cys Phe Pro Gly Gly Val His Trp Val Ser Val 
                165                 170                 175     


Gly Lys Gln Asp Lys Ser Gly Leu Leu Met Lys Leu Gln Asn Leu Cys 
            180                 185                 190         


Xaa Arg Leu Asp Gln Asp Glu Ser Phe Ser Gln Arg Leu Pro Leu Asn 
        195                 200                 205             


Ile Glu Glu Ala Lys Asp Arg Leu Arg Ile Leu Met Leu Arg Lys His 
    210                 215                 220                 


Pro Arg Ser Leu Leu Ile Leu Asp Asp Val Trp Asp Ser Trp Val Leu 
225                 230                 235                 240 


Lys Ala Phe Asp Ser Gln Cys Gln Ile Leu Leu Xaa Xaa Arg Asp Lys 
                245                 250                 255     


Ser Val Xaa Asp Ser Val Met Gly Pro Lys Tyr Val Val Pro Val Glu 
            260                 265                 270         


Ser Ser Leu Gly Lys Glu Lys Gly Leu Glu Ile Leu Ser Leu Phe Val 
        275                 280                 285             


Asn Met Lys Lys Ala Asp Leu Pro Glu Gln Ala His Ser Ile Ile Lys 
    290                 295                 300                 


Glu Cys Lys Gly Ser Pro Leu Val Val Ser Leu Ile Gly Ala Leu Leu 
305                 310                 315                 320 


Arg Asp Phe Pro Asn Arg Trp Glu Tyr Tyr Leu Lys Gln Leu Gln Asn 
                325                 330                 335     


Lys Gln Phe Lys Arg Ile Arg Lys Ser Ser Ser Tyr Asp Tyr Glu Ala 
            340                 345                 350         


Leu Asp Glu Ala Met Ser Ile Ser Val Glu Met Leu Arg Glu Asp Ile 
        355                 360                 365             


Lys Asp Tyr Tyr Xaa Asp Leu Ser Ile Leu Gln Lys Asp Val Lys Val 
    370                 375                 380                 


Pro Xaa Lys Val Leu Cys Ile Leu Trp Asp Met Glu Xaa Glu Glu Val 
385                 390                 395                 400 


Glu Asp Ile Leu Gln Glu Phe Val Asn Lys Ser Leu Leu Phe Cys Asp 
                405                 410                 415     


Arg Asn Gly Lys Ser Phe Arg Tyr Tyr Leu His Asp Leu Gln Val Asp 
            420                 425                 430         


Phe Leu Xaa Glu Lys Asn Cys Ser Gln Leu Gln Asp Leu His Lys Lys 
        435                 440                 445             


Ile Ile Xaa Gln Phe Gln Arg Tyr His Gln Pro His Xaa Leu Ser Pro 
    450                 455                 460                 


Asp Gln Glu Asp Cys Met Tyr Trp Tyr Asn Phe Leu Ala Tyr His Met 
465                 470                 475                 480 


Ala Ser Ala Lys Met His Lys Glu Leu Cys Ala Leu Met Phe Ser Leu 
                485                 490                 495     


Asp Trp Ile Lys Ala Lys Xaa Glu Leu Val Gly Pro Ala His Leu Ile 
            500                 505                 510         


His Glu Phe Val Glu Tyr Arg His Ile Leu Asp Glu Lys Asp Cys Ala 
        515                 520                 525             


Val Ser Glu Asn Phe Gln Glu Phe Leu Ser Leu Asn Gly His Leu Leu 
    530                 535                 540                 


Gly Arg Gln Pro Phe Pro Asn Ile Val Gln Leu Gly Leu Cys Glu Pro 
545                 550                 555                 560 


Glu Xaa Ser Glu Val Tyr Gln Gln Ala Lys Leu Gln Ala Lys Gln Glu 
                565                 570                 575     


Val Asp Asn Gly Met Leu Tyr Leu Glu Trp Ile Asn Lys Lys Asn Ile 
            580                 585                 590         


Xaa Asn Leu Ser Arg Leu Val Val Arg Pro His Xaa Asp Ala Val Tyr 
        595                 600                 605             


His Ala Cys Phe Ser Glu Asp Gly Gln Arg Ile Ala Ser Cys Gly Ala 
    610                 615                 620                 


Asp Lys Xaa Leu Gln Val Phe Lys Ala Glu Xaa Gly Glu Lys Leu Leu 
625                 630                 635                 640 


Glu Ile Lys Ala His Glu Asp Glu Val Leu Cys Cys Ala Phe Ser Xaa 
                645                 650                 655     


Asp Asp Arg Phe Ile Ala Xaa Cys Ser Val Asp Lys Lys Val Lys Ile 
            660                 665                 670         


Trp Asn Ser Met Xaa Gly Glu Leu Val His Xaa Tyr Asp Glu His Ser 
        675                 680                 685             


Glu Gln Val Asn Cys Cys His Phe Xaa Asn Ser Ser His His Leu Leu 
    690                 695                 700                 


Leu Ala Xaa Gly Ser Ser Asp Cys Phe Leu Lys Leu Trp Asp Leu Asn 
705                 710                 715                 720 


Gln Lys Glu Cys Arg Asn Xaa Met Phe Gly His Xaa Asn Ser Val Asn 
                725                 730                 735     


His Cys Arg Phe Ser Pro Asp Asp Lys Leu Leu Ala Ser Cys Ser Ala 
            740                 745                 750         


Asp Gly Xaa Leu Lys Leu Trp Asp Ala Xaa Ser Ala Asn Glu Arg Lys 
        755                 760                 765             


Ser Ile Asn Val Lys Gln Phe Phe Leu Asn Leu Glu Asp Pro Gln Glu 
    770                 775                 780                 


Asp Met Glu Val Ile Val Lys Cys Cys Ser Trp Ser Ala Asp Gly Ala 
785                 790                 795                 800 


Arg Ile Met Val Ala Ala Lys Asn Lys Ile Phe Leu Trp Asn Xaa Asp 
                805                 810                 815     


Ser Arg Ser Lys Val Ala Asp Cys Arg Gly His Leu Ser Trp Val His 
            820                 825                 830         


Gly Val Met Phe Ser Pro Asp Gly Ser Ser Phe Leu Xaa Ser Ser Asp 
        835                 840                 845             


Asp Gln Xaa Ile Arg Leu Trp Glu Xaa Lys Lys Val Cys Lys Asn Ser 
    850                 855                 860                 


Ala Val Met Leu Lys Gln Glu Val Asp Val Val Phe Gln Glu Asn Glu 
865                 870                 875                 880 


Val Met Val Leu Ala Val Asp His Ile Arg Arg Leu Gln Leu Ile Asn 
                885                 890                 895     


Gly Arg Xaa Gly Gln Ile Asp Tyr Leu Xaa Glu Ala Gln Val Ser Cys 
            900                 905                 910         


Cys Cys Leu Ser Pro His Leu Gln Tyr Ile Ala Phe Gly Asp Glu Asn 
        915                 920                 925             


Gly Ala Ile Glu Ile Leu Glu Leu Val Asn Asn Arg Ile Phe Gln Ser 
    930                 935                 940                 


Arg Phe Gln His Lys Lys Xaa Val Trp His Ile Gln Phe Xaa Ala Asp 
945                 950                 955                 960 


Glu Lys Xaa Leu Ile Ser Ser Ser Asp Asp Ala Glu Ile Gln Val Trp 
                965                 970                 975     


Asn Trp Gln Leu Asp Lys Cys Ile Phe Leu Arg Gly His Gln Glu Xaa 
            980                 985                 990         


Val Lys Asp Phe Arg Leu Leu Lys  Asn Ser Arg Leu Leu  Ser Trp Ser 
        995                 1000                 1005             


Phe Asp  Gly Xaa Val Lys Val  Trp Asn Ile Ile Xaa  Gly Asn Lys 
    1010                 1015                 1020             


Glu Lys  Asp Phe Val Cys His  Gln Gly Xaa Val Leu  Ser Cys Asp 
    1025                 1030                 1035             


Ile Ser  His Asp Ala Xaa Lys  Phe Ser Ser Xaa Ser  Ala Asp Lys 
    1040                 1045                 1050             


Xaa Ala  Lys Ile Trp Ser Phe  Asp Leu Leu Leu Pro  Leu His Glu 
    1055                 1060                 1065             


Leu Arg  Gly His Asn Gly Cys  Val Arg Cys Ser Ala  Phe Ser Val 
    1070                 1075                 1080             


Asp Ser  Xaa Leu Leu Ala Xaa  Gly Asp Asp Asn Gly  Glu Ile Arg 
    1085                 1090                 1095             


Ile Trp  Asn Val Ser Asn Gly  Glu Leu Leu His Leu  Cys Ala Pro 
    1100                 1105                 1110             


Leu Ser  Glu Glu Gly Ala Ala  Xaa His Gly Gly Trp  Val Xaa Asp 
    1115                 1120                 1125             


Leu Cys  Phe Ser Pro Asp Gly  Lys Met Leu Ile Ser  Ala Gly Gly 
    1130                 1135                 1140             


Tyr Ile  Lys Trp Trp Asn Val  Val Xaa Gly Glu Ser  Ser Gln Xaa 
    1145                 1150                 1155             


Phe Tyr  Xaa Asn Gly Xaa Asn  Leu Lys Lys Ile His  Val Ser Pro 
    1160                 1165                 1170             


Asp Phe  Lys Xaa Tyr Val Xaa  Val Asp Asn Leu Gly  Ile Leu Tyr 
    1175                 1180                 1185             


Ile Leu  Gln Xaa Leu Glu 
    1190                 


<210> 2496
<211> 1237
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1195)..(1195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1235)..(1235)
<223> Selenocysteine

<400> 2496
Met Asp Ala Lys Ala Arg Asn Cys Leu Leu Gln His Arg Glu Ala Leu 
1               5                   10                  15      


Glu Lys Asp Ile Lys Xaa Ser Tyr Ile Met Asp His Met Ile Ser Asp 
            20                  25                  30          


Gly Phe Leu Xaa Ile Ser Glu Glu Glu Lys Val Arg Asn Glu Pro Xaa 
        35                  40                  45              


Gln Gln Gln Arg Ala Ala Met Leu Ile Lys Met Ile Leu Lys Lys Asp 
    50                  55                  60                  


Asn Asp Ser Tyr Val Ser Phe Tyr Asn Ala Leu Leu His Glu Gly Tyr 
65                  70                  75                  80  


Lys Asp Leu Ala Ala Leu Leu His Asp Gly Ile Pro Val Val Ser Ser 
                85                  90                  95      


Ser Ser Val Arg Xaa Val Leu Cys Glu Gly Gly Val Pro Gln Arg Pro 
            100                 105                 110         


Val Val Phe Val Xaa Arg Lys Lys Leu Val Asn Ala Ile Gln Gln Lys 
        115                 120                 125             


Leu Ser Lys Leu Lys Gly Glu Pro Gly Trp Val Xaa Ile His Gly Met 
    130                 135                 140                 


Ala Gly Cys Gly Lys Ser Val Leu Ala Ala Glu Ala Val Arg Asp His 
145                 150                 155                 160 


Ser Leu Leu Glu Gly Cys Phe Pro Gly Gly Val His Trp Val Ser Val 
                165                 170                 175     


Gly Lys Gln Asp Lys Ser Gly Leu Leu Met Lys Leu Gln Asn Leu Cys 
            180                 185                 190         


Xaa Arg Leu Asp Gln Asp Glu Ser Phe Ser Gln Arg Leu Pro Leu Asn 
        195                 200                 205             


Ile Glu Glu Ala Lys Asp Arg Leu Arg Ile Leu Met Leu Arg Lys His 
    210                 215                 220                 


Pro Arg Ser Leu Leu Ile Leu Asp Asp Val Trp Asp Ser Trp Val Leu 
225                 230                 235                 240 


Lys Ala Phe Asp Ser Gln Cys Gln Ile Leu Leu Xaa Xaa Arg Asp Lys 
                245                 250                 255     


Ser Val Xaa Asp Ser Val Met Gly Pro Lys Tyr Val Val Pro Val Glu 
            260                 265                 270         


Ser Ser Leu Gly Lys Glu Lys Gly Leu Glu Ile Leu Ser Leu Phe Val 
        275                 280                 285             


Asn Met Lys Lys Ala Asp Leu Pro Glu Gln Ala His Ser Ile Ile Lys 
    290                 295                 300                 


Glu Cys Lys Gly Ser Pro Leu Val Val Ser Leu Ile Gly Ala Leu Leu 
305                 310                 315                 320 


Arg Asp Phe Pro Asn Arg Trp Glu Tyr Tyr Leu Lys Gln Leu Gln Asn 
                325                 330                 335     


Lys Gln Phe Lys Arg Ile Arg Lys Ser Ser Ser Tyr Asp Tyr Glu Ala 
            340                 345                 350         


Leu Asp Glu Ala Met Ser Ile Ser Val Glu Met Leu Arg Glu Asp Ile 
        355                 360                 365             


Lys Asp Tyr Tyr Xaa Asp Leu Ser Ile Leu Gln Lys Asp Val Lys Val 
    370                 375                 380                 


Pro Xaa Lys Val Leu Cys Ile Leu Trp Asp Met Glu Xaa Glu Glu Val 
385                 390                 395                 400 


Glu Asp Ile Leu Gln Glu Phe Val Asn Lys Ser Leu Leu Phe Cys Asp 
                405                 410                 415     


Arg Asn Gly Lys Ser Phe Arg Tyr Tyr Leu His Asp Leu Gln Val Asp 
            420                 425                 430         


Phe Leu Xaa Glu Lys Asn Cys Ser Gln Leu Gln Asp Leu His Lys Lys 
        435                 440                 445             


Ile Ile Xaa Gln Phe Gln Arg Tyr His Gln Pro His Xaa Leu Ser Pro 
    450                 455                 460                 


Asp Gln Glu Asp Cys Met Tyr Trp Tyr Asn Phe Leu Ala Tyr His Met 
465                 470                 475                 480 


Ala Ser Ala Lys Met His Lys Glu Leu Cys Ala Leu Met Phe Ser Leu 
                485                 490                 495     


Asp Trp Ile Lys Ala Lys Xaa Glu Leu Val Gly Pro Ala His Leu Ile 
            500                 505                 510         


His Glu Phe Val Glu Tyr Arg His Ile Leu Asp Glu Lys Asp Cys Ala 
        515                 520                 525             


Val Ser Glu Asn Phe Gln Glu Phe Leu Ser Leu Asn Gly His Leu Leu 
    530                 535                 540                 


Gly Arg Gln Pro Phe Pro Asn Ile Val Gln Leu Gly Leu Cys Glu Pro 
545                 550                 555                 560 


Glu Xaa Ser Glu Val Tyr Gln Gln Ala Lys Leu Gln Ala Lys Gln Glu 
                565                 570                 575     


Val Asp Asn Gly Met Leu Tyr Leu Glu Trp Ile Asn Lys Lys Asn Ile 
            580                 585                 590         


Xaa Asn Leu Ser Arg Leu Val Val Arg Pro His Xaa Asp Ala Val Tyr 
        595                 600                 605             


His Ala Cys Phe Ser Glu Asp Gly Gln Arg Ile Ala Ser Cys Gly Ala 
    610                 615                 620                 


Asp Lys Xaa Leu Gln Val Phe Lys Ala Glu Xaa Gly Glu Lys Leu Leu 
625                 630                 635                 640 


Glu Ile Lys Ala His Glu Asp Glu Val Leu Cys Cys Ala Phe Ser Xaa 
                645                 650                 655     


Asp Asp Arg Phe Ile Ala Xaa Cys Ser Val Asp Lys Lys Val Lys Ile 
            660                 665                 670         


Trp Asn Ser Met Xaa Gly Glu Leu Val His Xaa Tyr Asp Glu His Ser 
        675                 680                 685             


Glu Gln Val Asn Cys Cys His Phe Xaa Asn Ser Ser His His Leu Leu 
    690                 695                 700                 


Leu Ala Xaa Gly Ser Ser Asp Cys Phe Leu Lys Leu Trp Asp Leu Asn 
705                 710                 715                 720 


Gln Lys Glu Cys Arg Asn Xaa Met Phe Gly His Xaa Asn Ser Val Asn 
                725                 730                 735     


His Cys Arg Phe Ser Pro Asp Asp Lys Leu Leu Ala Ser Cys Ser Ala 
            740                 745                 750         


Asp Gly Xaa Leu Lys Leu Trp Asp Ala Xaa Ser Ala Asn Glu Arg Lys 
        755                 760                 765             


Ser Ile Asn Val Lys Gln Phe Phe Leu Asn Leu Glu Asp Pro Gln Glu 
    770                 775                 780                 


Asp Met Glu Val Ile Val Lys Cys Cys Ser Trp Ser Ala Asp Gly Ala 
785                 790                 795                 800 


Arg Ile Met Val Ala Ala Lys Asn Lys Ile Phe Leu Phe Asp Ile His 
                805                 810                 815     


Xaa Ser Gly Leu Leu Gly Glu Ile His Xaa Gly His His Ser Xaa Ile 
            820                 825                 830         


Gln Tyr Cys Asp Phe Ser Pro Gln Asn His Leu Ala Val Val Ala Leu 
        835                 840                 845             


Ser Gln Tyr Cys Val Glu Leu Trp Asn Xaa Asp Ser Arg Ser Lys Val 
    850                 855                 860                 


Ala Asp Cys Arg Gly His Leu Ser Trp Val His Gly Val Met Phe Ser 
865                 870                 875                 880 


Pro Asp Gly Ser Ser Phe Leu Xaa Ser Ser Asp Asp Gln Xaa Ile Arg 
                885                 890                 895     


Leu Trp Glu Xaa Lys Lys Val Cys Lys Asn Ser Ala Val Met Leu Lys 
            900                 905                 910         


Gln Glu Val Asp Val Val Phe Gln Glu Asn Glu Val Met Val Leu Ala 
        915                 920                 925             


Val Asp His Ile Arg Arg Leu Gln Leu Ile Asn Gly Arg Xaa Gly Gln 
    930                 935                 940                 


Ile Asp Tyr Leu Xaa Glu Ala Gln Val Ser Cys Cys Cys Leu Ser Pro 
945                 950                 955                 960 


His Leu Gln Tyr Ile Ala Phe Gly Asp Glu Asn Gly Ala Ile Glu Ile 
                965                 970                 975     


Leu Glu Leu Val Asn Asn Arg Ile Phe Gln Ser Arg Phe Gln His Lys 
            980                 985                 990         


Lys Xaa Val Trp His Ile Gln Phe  Xaa Ala Asp Glu Lys  Xaa Leu Ile 
        995                 1000                 1005             


Ser Ser  Ser Asp Asp Ala Glu  Ile Gln Val Trp Asn  Trp Gln Leu 
    1010                 1015                 1020             


Asp Lys  Cys Ile Phe Leu Arg  Gly His Gln Glu Xaa  Val Lys Asp 
    1025                 1030                 1035             


Phe Arg  Leu Leu Lys Asn Ser  Arg Leu Leu Ser Trp  Ser Phe Asp 
    1040                 1045                 1050             


Gly Xaa  Val Lys Val Trp Asn  Ile Ile Xaa Gly Asn  Lys Glu Lys 
    1055                 1060                 1065             


Asp Phe  Val Cys His Gln Gly  Xaa Val Leu Ser Cys  Asp Ile Ser 
    1070                 1075                 1080             


His Asp  Ala Xaa Lys Phe Ser  Ser Xaa Ser Ala Asp  Lys Xaa Ala 
    1085                 1090                 1095             


Lys Ile  Trp Ser Phe Asp Leu  Leu Leu Pro Leu His  Glu Leu Arg 
    1100                 1105                 1110             


Gly His  Asn Gly Cys Val Arg  Cys Ser Ala Phe Ser  Val Asp Ser 
    1115                 1120                 1125             


Xaa Leu  Leu Ala Xaa Gly Asp  Asp Asn Gly Glu Ile  Arg Ile Trp 
    1130                 1135                 1140             


Asn Val  Ser Asn Gly Glu Leu  Leu His Leu Cys Ala  Pro Leu Ser 
    1145                 1150                 1155             


Glu Glu  Gly Ala Ala Xaa His  Gly Gly Trp Val Xaa  Asp Leu Cys 
    1160                 1165                 1170             


Phe Ser  Pro Asp Gly Lys Met  Leu Ile Ser Ala Gly  Gly Tyr Ile 
    1175                 1180                 1185             


Lys Trp  Trp Asn Val Val Xaa  Gly Glu Ser Ser Gln  Xaa Phe Tyr 
    1190                 1195                 1200             


Xaa Asn  Gly Xaa Asn Leu Lys  Lys Ile His Val Ser  Pro Asp Phe 
    1205                 1210                 1215             


Lys Xaa  Tyr Val Xaa Val Asp  Asn Leu Gly Ile Leu  Tyr Ile Leu 
    1220                 1225                 1230             


Gln Xaa  Leu Glu 
    1235         


<210> 2497
<211> 235
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<400> 2497
Met Leu Lys Cys His Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile 
1               5                   10                  15      


Ala Xaa Ser Leu His Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg 
            20                  25                  30          


Asn Ala Arg Cys Leu Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu 
        35                  40                  45              


Val Asp Val Pro Phe Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu 
    50                  55                  60                  


Val Gln Lys Phe Gln Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys 
65                  70                  75                  80  


Pro Val Gly Val Asp Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser 
                85                  90                  95      


Ser Ser Ser Arg Glu Gln Trp Xaa Pro Ser His Val Ser Val Ala Pro 
            100                 105                 110         


Ala Xaa Leu Xaa Ile Leu His Gln Gln Xaa Glu Ala Val Leu Gly Glu 
        115                 120                 125             


Cys Arg Val Arg Phe Leu Ser Phe Leu Ala Val Gly Arg Asp Val His 
    130                 135                 140                 


Xaa Phe Ala Phe Ile Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His 
145                 150                 155                 160 


Met Phe Trp Cys Glu Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln 
                165                 170                 175     


Ala Ala Cys Met Leu Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln 
            180                 185                 190         


Ala Ser Xaa Ser Cys Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg 
        195                 200                 205             


Arg Val Gly Trp Xaa Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser 
    210                 215                 220                 


Leu Lys Pro Lys Arg Leu Gly Ala His Xaa Pro 
225                 230                 235 


<210> 2498
<211> 87
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 2498
Met Arg Val Gln Asp Xaa Ser Gly Xaa Tyr Tyr Trp His Ile Pro Xaa 
1               5                   10                  15      


Gly Xaa Xaa Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro Ser Gln Gly 
            20                  25                  30          


Ser Ser Pro Gln Glu Glu Ser Gln Leu Xaa Trp Xaa Gly Phe Ala His 
        35                  40                  45              


Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu Pro Ser Asp 
    50                  55                  60                  


Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu Gly Xaa Leu 
65                  70                  75                  80  


Xaa Phe Pro Ala Gln Ser Leu 
                85          


<210> 2499
<211> 262
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<400> 2499
Met Arg Val Gln Asp Xaa Ser Gly Xaa Tyr Tyr Trp His Ile Pro Xaa 
1               5                   10                  15      


Gly Xaa Xaa Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro Ser Gln Gly 
            20                  25                  30          


Ser Ser Pro Gln Glu Glu Ser Gln Leu Xaa Trp Xaa Gly Phe Ala His 
        35                  40                  45              


Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu Pro Ser Asp 
    50                  55                  60                  


Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu Gly Xaa Leu 
65                  70                  75                  80  


Xaa Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro Gln Glu Glu 
                85                  90                  95      


Glu Lys Leu Pro Pro Arg Asn Xaa Asn Pro Gly Ile Lys Cys Phe Ala 
            100                 105                 110         


Val Arg Ser Leu Gly Trp Val Glu Met Xaa Glu Glu Glu Leu Ala Pro 
        115                 120                 125             


Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln Leu Ser Tyr 
    130                 135                 140                 


His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp Gly Glu Gly 
145                 150                 155                 160 


Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Xaa Leu Lys Leu Val Glu 
                165                 170                 175     


Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile Ser Ile Arg 
            180                 185                 190         


Val Trp Gly Val Gly Arg Asp Ser Gly Arg Asp Phe Ala Tyr Val Ala 
        195                 200                 205             


Arg Asp Lys Leu Xaa Gln Met Leu Lys Cys His Val Phe Arg Cys Glu 
    210                 215                 220                 


Ala Pro Ala Lys Asn Ile Ala Xaa Ser Leu His Glu Ile Cys Ser Lys 
225                 230                 235                 240 


Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu Val Asn Gly Leu Ser 
                245                 250                 255     


Leu Asp His Ser Lys Leu 
            260         


<210> 2500
<211> 451
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<400> 2500
Met Arg Val Gln Asp Xaa Ser Gly Xaa Tyr Tyr Trp His Ile Pro Xaa 
1               5                   10                  15      


Gly Xaa Xaa Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro Ser Gln Gly 
            20                  25                  30          


Ser Ser Pro Gln Glu Glu Ser Gln Leu Xaa Trp Xaa Gly Phe Ala His 
        35                  40                  45              


Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu Pro Ser Asp 
    50                  55                  60                  


Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu Gly Xaa Leu 
65                  70                  75                  80  


Xaa Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro Gln Glu Glu 
                85                  90                  95      


Glu Lys Leu Pro Pro Arg Asn Xaa Asn Pro Gly Ile Lys Cys Phe Ala 
            100                 105                 110         


Val Arg Ser Leu Gly Trp Val Glu Met Xaa Glu Glu Glu Leu Ala Pro 
        115                 120                 125             


Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln Leu Ser Tyr 
    130                 135                 140                 


His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp Gly Glu Gly 
145                 150                 155                 160 


Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Xaa Leu Lys Leu Val Glu 
                165                 170                 175     


Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile Ser Ile Arg 
            180                 185                 190         


Val Trp Gly Val Gly Arg Asp Ser Gly Arg Glu Arg Asp Phe Ala Tyr 
        195                 200                 205             


Val Ala Arg Asp Lys Leu Xaa Gln Met Leu Lys Cys His Val Phe Arg 
    210                 215                 220                 


Cys Glu Ala Pro Ala Lys Asn Ile Ala Xaa Ser Leu His Glu Ile Cys 
225                 230                 235                 240 


Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu Val Asn Gly 
                245                 250                 255     


Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe Gln Val Glu 
            260                 265                 270         


Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln Val Tyr Tyr 
        275                 280                 285             


Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp Val Ile Asn 
    290                 295                 300                 


Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu Gln Trp Xaa 
305                 310                 315                 320 


Pro Ser His Val Ser Val Ala Pro Ala Xaa Leu Xaa Ile Leu His Gln 
                325                 330                 335     


Gln Xaa Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe Leu Ser Phe 
            340                 345                 350         


Leu Ala Val Gly Arg Asp Val His Xaa Phe Ala Phe Ile Met Ala Ala 
        355                 360                 365             


Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu Pro Asn Ala 
    370                 375                 380                 


Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu Arg Tyr Gln 
385                 390                 395                 400 


Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Xaa Ser Cys Leu Pro Ala 
                405                 410                 415     


Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Xaa Val Arg Arg 
            420                 425                 430         


Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg Leu Gly Ala 
        435                 440                 445             


His Xaa Pro 
    450     


<210> 2501
<211> 451
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<400> 2501
Met Arg Val Gln Asp Xaa Ser Gly Xaa Tyr Tyr Trp His Ile Pro Xaa 
1               5                   10                  15      


Gly Xaa Xaa Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro Ser Gln Gly 
            20                  25                  30          


Ser Ser Pro Gln Glu Glu Ser Gln Leu Xaa Trp Xaa Gly Phe Ala His 
        35                  40                  45              


Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu Pro Ser Asp 
    50                  55                  60                  


Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu Gly Xaa Leu 
65                  70                  75                  80  


Xaa Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro Gln Glu Glu 
                85                  90                  95      


Glu Lys Leu Pro Pro Arg Asn Xaa Asn Pro Gly Ile Lys Cys Phe Ala 
            100                 105                 110         


Val Arg Ser Leu Gly Trp Val Glu Met Xaa Glu Glu Glu Leu Ala Pro 
        115                 120                 125             


Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln Leu Ser Tyr 
    130                 135                 140                 


His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp Gly Glu Gly 
145                 150                 155                 160 


Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Xaa Leu Lys Leu Val Glu 
                165                 170                 175     


Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile Ser Ile Arg 
            180                 185                 190         


Val Trp Gly Val Gly Arg Asp Ser Gly Ser Asn Arg Asp Phe Ala Tyr 
        195                 200                 205             


Val Ala Arg Asp Lys Leu Xaa Gln Met Leu Lys Cys His Val Phe Arg 
    210                 215                 220                 


Cys Glu Ala Pro Ala Lys Asn Ile Ala Xaa Ser Leu His Glu Ile Cys 
225                 230                 235                 240 


Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu Val Asn Gly 
                245                 250                 255     


Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe Gln Val Glu 
            260                 265                 270         


Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln Val Tyr Tyr 
        275                 280                 285             


Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp Val Ile Asn 
    290                 295                 300                 


Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu Gln Trp Xaa 
305                 310                 315                 320 


Pro Ser His Val Ser Val Ala Pro Ala Xaa Leu Xaa Ile Leu His Gln 
                325                 330                 335     


Gln Xaa Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe Leu Ser Phe 
            340                 345                 350         


Leu Ala Val Gly Arg Asp Val His Xaa Phe Ala Phe Ile Met Ala Ala 
        355                 360                 365             


Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu Pro Asn Ala 
    370                 375                 380                 


Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu Arg Tyr Gln 
385                 390                 395                 400 


Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Xaa Ser Cys Leu Pro Ala 
                405                 410                 415     


Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Xaa Val Arg Arg 
            420                 425                 430         


Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg Leu Gly Ala 
        435                 440                 445             


His Xaa Pro 
    450     


<210> 2502
<211> 488
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<400> 2502
Met Ser Ala Met Phe Ser Gln Asp Phe Phe Leu Ala Ile Ile Leu Gln 
1               5                   10                  15      


Asp Ser Ser Ala Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Xaa Asp 
            20                  25                  30          


Ser Asp Leu Pro Ala Gly Trp Met Arg Val Gln Asp Xaa Ser Gly Xaa 
        35                  40                  45              


Tyr Tyr Trp His Ile Pro Xaa Gly Xaa Xaa Gln Trp Glu Pro Pro Gly 
    50                  55                  60                  


Arg Ala Ser Pro Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu 
65                  70                  75                  80  


Xaa Trp Xaa Gly Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe 
                85                  90                  95      


Trp Lys Asp Glu Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys 
            100                 105                 110         


Glu Pro Glu Glu Gly Xaa Leu Xaa Phe Pro Ala Gln Ser Leu Ser Pro 
        115                 120                 125             


Glu Pro Leu Pro Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Xaa Asn 
    130                 135                 140                 


Pro Gly Ile Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met 
145                 150                 155                 160 


Xaa Glu Glu Glu Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn 
                165                 170                 175     


Cys Ile Arg Gln Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met 
            180                 185                 190         


Ser Gly Gly Trp Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp 
        195                 200                 205             


Glu Xaa Leu Lys Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala 
    210                 215                 220                 


Gln Pro Ile Ile Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly 
225                 230                 235                 240 


Arg Asp Phe Ala Tyr Val Ala Arg Asp Lys Leu Xaa Gln Met Leu Lys 
                245                 250                 255     


Cys His Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Xaa Ser 
            260                 265                 270         


Leu His Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg 
        275                 280                 285             


Cys Leu Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val 
    290                 295                 300                 


Pro Phe Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys 
305                 310                 315                 320 


Phe Gln Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly 
                325                 330                 335     


Val Asp Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser 
            340                 345                 350         


Arg Glu Gln Trp Xaa Pro Ser His Val Ser Val Ala Pro Ala Xaa Leu 
        355                 360                 365             


Xaa Ile Leu His Gln Gln Xaa Glu Ala Val Leu Gly Glu Cys Arg Val 
    370                 375                 380                 


Arg Phe Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Xaa Phe Ala 
385                 390                 395                 400 


Phe Ile Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp 
                405                 410                 415     


Cys Glu Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys 
            420                 425                 430         


Met Leu Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Xaa 
        435                 440                 445             


Ser Cys Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly 
    450                 455                 460                 


Trp Xaa Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro 
465                 470                 475                 480 


Lys Arg Leu Gly Ala His Xaa Pro 
                485             


<210> 2503
<211> 490
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<400> 2503
Met Ser Ala Met Phe Ser Gln Asp Phe Phe Leu Ala Ile Ile Leu Gln 
1               5                   10                  15      


Asp Ser Ser Ala Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Xaa Asp 
            20                  25                  30          


Ser Asp Leu Pro Ala Gly Trp Met Arg Val Gln Asp Xaa Ser Gly Xaa 
        35                  40                  45              


Tyr Tyr Trp His Ile Pro Xaa Gly Xaa Xaa Gln Trp Glu Pro Pro Gly 
    50                  55                  60                  


Arg Ala Ser Pro Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu 
65                  70                  75                  80  


Xaa Trp Xaa Gly Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe 
                85                  90                  95      


Trp Lys Asp Glu Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys 
            100                 105                 110         


Glu Pro Glu Glu Gly Xaa Leu Xaa Phe Pro Ala Gln Ser Leu Ser Pro 
        115                 120                 125             


Glu Pro Leu Pro Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Xaa Asn 
    130                 135                 140                 


Pro Gly Ile Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met 
145                 150                 155                 160 


Xaa Glu Glu Glu Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn 
                165                 170                 175     


Cys Ile Arg Gln Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met 
            180                 185                 190         


Ser Gly Gly Trp Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp 
        195                 200                 205             


Glu Xaa Leu Lys Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala 
    210                 215                 220                 


Gln Pro Ile Ile Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly 
225                 230                 235                 240 


Arg Glu Arg Asp Phe Ala Tyr Val Ala Arg Asp Lys Leu Xaa Gln Met 
                245                 250                 255     


Leu Lys Cys His Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala 
            260                 265                 270         


Xaa Ser Leu His Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg Asn 
        275                 280                 285             


Ala Arg Cys Leu Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val 
    290                 295                 300                 


Asp Val Pro Phe Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val 
305                 310                 315                 320 


Gln Lys Phe Gln Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro 
                325                 330                 335     


Val Gly Val Asp Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser 
            340                 345                 350         


Ser Ser Arg Glu Gln Trp Xaa Pro Ser His Val Ser Val Ala Pro Ala 
        355                 360                 365             


Xaa Leu Xaa Ile Leu His Gln Gln Xaa Glu Ala Val Leu Gly Glu Cys 
    370                 375                 380                 


Arg Val Arg Phe Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Xaa 
385                 390                 395                 400 


Phe Ala Phe Ile Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met 
                405                 410                 415     


Phe Trp Cys Glu Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala 
            420                 425                 430         


Ala Cys Met Leu Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln Ala 
        435                 440                 445             


Ser Xaa Ser Cys Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg Arg 
    450                 455                 460                 


Val Gly Trp Xaa Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser Leu 
465                 470                 475                 480 


Lys Pro Lys Arg Leu Gly Ala His Xaa Pro 
                485                 490 


<210> 2504
<211> 707
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<400> 2504
Met Ser Val Pro Ser Ser Leu Ser Gln Ser Ala Ile Asn Ala Asn Ser 
1               5                   10                  15      


His Gly Gly Pro Ala Leu Ser Leu Pro Leu Pro Leu His Ala Ala His 
            20                  25                  30          


Asn Gln Leu Leu Asn Ala Lys Leu Gln Ala Xaa Ala Val Gly Pro Lys 
        35                  40                  45              


Asp Leu Arg Ser Ala Met Gly Glu Gly Gly Gly Pro Glu Pro Gly Pro 
    50                  55                  60                  


Ala Asn Ala Lys Trp Leu Lys Glu Gly Gln Asn Gln Leu Arg Arg Ala 
65                  70                  75                  80  


Ala Xaa Ala His Arg Asp Gln Asn Arg Asn Val Xaa Leu Xaa Leu Ala 
                85                  90                  95      


Glu Glu Ala Ser Gln Glu Pro Glu Met Ala Pro Leu Gly Pro Lys Gly 
            100                 105                 110         


Leu Ile His Leu Tyr Ser Glu Leu Glu Leu Ser Ala His Asn Ala Ala 
        115                 120                 125             


Asn Arg Gly Leu Arg Gly Pro Gly Leu Ile Ile Ser Xaa Gln Glu Gln 
    130                 135                 140                 


Gly Pro Asp Glu Gly Glu Glu Lys Ala Ala Gly Glu Ala Glu Glu Glu 
145                 150                 155                 160 


Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu Glu Asp Leu Ser Ser Pro 
                165                 170                 175     


Pro Gly Leu Pro Glu Pro Leu Glu Ser Val Glu Ala Pro Pro Arg Pro 
            180                 185                 190         


Gln Ala Leu Xaa Asp Gly Pro Arg Glu His Ser Lys Ser Ala Ser Leu 
        195                 200                 205             


Leu Phe Gly Met Arg Asn Ser Ala Ala Ser Asp Glu Asp Ser Ser Trp 
    210                 215                 220                 


Ala Xaa Leu Ser Gln Gly Ser Pro Ser Tyr Gly Ser Pro Glu Asp Xaa 
225                 230                 235                 240 


Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Xaa Asp Ser Asp Leu Pro 
                245                 250                 255     


Ala Gly Trp Met Arg Val Gln Asp Xaa Ser Gly Xaa Tyr Tyr Trp His 
            260                 265                 270         


Ile Pro Xaa Gly Xaa Xaa Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro 
        275                 280                 285             


Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu Xaa Trp Xaa Gly 
    290                 295                 300                 


Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu 
305                 310                 315                 320 


Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu 
                325                 330                 335     


Gly Xaa Leu Xaa Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro 
            340                 345                 350         


Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Xaa Asn Pro Gly Ile Lys 
        355                 360                 365             


Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Xaa Glu Glu Glu 
    370                 375                 380                 


Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln 
385                 390                 395                 400 


Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp 
                405                 410                 415     


Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Xaa Leu Lys 
            420                 425                 430         


Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile 
        435                 440                 445             


Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly Arg Glu Arg Asp 
    450                 455                 460                 


Phe Ala Tyr Val Ala Arg Asp Lys Leu Xaa Gln Met Leu Lys Cys His 
465                 470                 475                 480 


Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Xaa Ser Leu His 
                485                 490                 495     


Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu 
            500                 505                 510         


Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe 
        515                 520                 525             


Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln 
    530                 535                 540                 


Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp 
545                 550                 555                 560 


Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu 
                565                 570                 575     


Gln Trp Xaa Pro Ser His Val Ser Val Ala Pro Ala Xaa Leu Xaa Ile 
            580                 585                 590         


Leu His Gln Gln Xaa Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe 
        595                 600                 605             


Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Xaa Phe Ala Phe Ile 
    610                 615                 620                 


Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu 
625                 630                 635                 640 


Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Val 
                645                 650                 655     


Glu Gln Glu Glu Leu Val Gln Ala Arg Pro His Pro Pro Gly Pro Ser 
            660                 665                 670         


Arg Gly Arg Arg Arg Lys Gly Leu Val Gln Ala Trp Val Pro Ser Pro 
        675                 680                 685             


Cys Ser Met Gly Xaa Ser Ala Val Leu Ile Ser Leu Ile Lys Ser Val 
    690                 695                 700                 


Cys Xaa Ala 
705         


<210> 2505
<211> 708
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<400> 2505
Met Ser Val Pro Ser Ser Leu Ser Gln Ser Ala Ile Asn Ala Asn Ser 
1               5                   10                  15      


His Gly Gly Pro Ala Leu Ser Leu Pro Leu Pro Leu His Ala Ala His 
            20                  25                  30          


Asn Gln Leu Leu Asn Ala Lys Leu Gln Ala Xaa Ala Val Gly Pro Lys 
        35                  40                  45              


Asp Leu Arg Ser Ala Met Gly Glu Gly Gly Gly Pro Glu Pro Gly Pro 
    50                  55                  60                  


Ala Asn Ala Lys Trp Leu Lys Glu Gly Gln Asn Gln Leu Arg Arg Ala 
65                  70                  75                  80  


Ala Xaa Ala His Arg Asp Gln Asn Arg Asn Val Xaa Leu Xaa Leu Ala 
                85                  90                  95      


Glu Glu Ala Ser Gln Glu Pro Glu Met Ala Pro Leu Gly Pro Lys Gly 
            100                 105                 110         


Leu Ile His Leu Tyr Ser Glu Leu Glu Leu Ser Ala His Asn Ala Ala 
        115                 120                 125             


Asn Arg Gly Leu Arg Gly Pro Gly Leu Ile Ile Ser Xaa Gln Glu Gln 
    130                 135                 140                 


Gly Pro Asp Glu Gly Glu Glu Lys Ala Ala Gly Glu Ala Glu Glu Glu 
145                 150                 155                 160 


Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu Glu Asp Leu Ser Ser Pro 
                165                 170                 175     


Pro Gly Leu Pro Glu Pro Leu Glu Ser Val Glu Ala Pro Pro Arg Pro 
            180                 185                 190         


Gln Ala Leu Xaa Asp Gly Pro Arg Glu His Ser Lys Ser Ala Ser Leu 
        195                 200                 205             


Leu Phe Gly Met Arg Asn Ser Ala Ala Ser Asp Glu Asp Ser Ser Trp 
    210                 215                 220                 


Ala Xaa Leu Ser Gln Gly Ser Pro Ser Tyr Gly Ser Pro Glu Asp Xaa 
225                 230                 235                 240 


Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Xaa Asp Ser Asp Leu Pro 
                245                 250                 255     


Ala Gly Trp Met Arg Val Gln Asp Xaa Ser Gly Xaa Tyr Tyr Trp His 
            260                 265                 270         


Ile Pro Xaa Gly Xaa Xaa Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro 
        275                 280                 285             


Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu Xaa Trp Xaa Gly 
    290                 295                 300                 


Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu 
305                 310                 315                 320 


Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu 
                325                 330                 335     


Gly Xaa Leu Xaa Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro 
            340                 345                 350         


Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Xaa Asn Pro Gly Ile Lys 
        355                 360                 365             


Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Xaa Glu Glu Glu 
    370                 375                 380                 


Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln 
385                 390                 395                 400 


Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp 
                405                 410                 415     


Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Xaa Leu Lys 
            420                 425                 430         


Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile 
        435                 440                 445             


Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly Arg Asp Phe Ala 
    450                 455                 460                 


Tyr Val Ala Arg Asp Lys Leu Xaa Gln Met Leu Lys Cys His Val Phe 
465                 470                 475                 480 


Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Xaa Ser Leu His Glu Ile 
                485                 490                 495     


Cys Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu Val Asn 
            500                 505                 510         


Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe Gln Val 
        515                 520                 525             


Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln Val Tyr 
    530                 535                 540                 


Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp Val Ile 
545                 550                 555                 560 


Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu Gln Trp 
                565                 570                 575     


Xaa Pro Ser His Val Ser Val Ala Pro Ala Xaa Leu Xaa Ile Leu His 
            580                 585                 590         


Gln Gln Xaa Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe Leu Ser 
        595                 600                 605             


Phe Leu Ala Val Gly Arg Asp Val His Xaa Phe Ala Phe Ile Met Ala 
    610                 615                 620                 


Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu Pro Asn 
625                 630                 635                 640 


Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu Arg Tyr 
                645                 650                 655     


Gln Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Xaa Ser Cys Leu Pro 
            660                 665                 670         


Ala Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Xaa Val Arg 
        675                 680                 685             


Arg Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg Leu Gly 
    690                 695                 700                 


Ala His Xaa Pro 
705             


<210> 2506
<211> 710
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<400> 2506
Met Ser Val Pro Ser Ser Leu Ser Gln Ser Ala Ile Asn Ala Asn Ser 
1               5                   10                  15      


His Gly Gly Pro Ala Leu Ser Leu Pro Leu Pro Leu His Ala Ala His 
            20                  25                  30          


Asn Gln Leu Leu Asn Ala Lys Leu Gln Ala Xaa Ala Val Gly Pro Lys 
        35                  40                  45              


Asp Leu Arg Ser Ala Met Gly Glu Gly Gly Gly Pro Glu Pro Gly Pro 
    50                  55                  60                  


Ala Asn Ala Lys Trp Leu Lys Glu Gly Gln Asn Gln Leu Arg Arg Ala 
65                  70                  75                  80  


Ala Xaa Ala His Arg Asp Gln Asn Arg Asn Val Xaa Leu Xaa Leu Ala 
                85                  90                  95      


Glu Glu Ala Ser Gln Glu Pro Glu Met Ala Pro Leu Gly Pro Lys Gly 
            100                 105                 110         


Leu Ile His Leu Tyr Ser Glu Leu Glu Leu Ser Ala His Asn Ala Ala 
        115                 120                 125             


Asn Arg Gly Leu Arg Gly Pro Gly Leu Ile Ile Ser Xaa Gln Glu Gln 
    130                 135                 140                 


Gly Pro Asp Glu Gly Glu Glu Lys Ala Ala Gly Glu Ala Glu Glu Glu 
145                 150                 155                 160 


Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu Glu Asp Leu Ser Ser Pro 
                165                 170                 175     


Pro Gly Leu Pro Glu Pro Leu Glu Ser Val Glu Ala Pro Pro Arg Pro 
            180                 185                 190         


Gln Ala Leu Xaa Asp Gly Pro Arg Glu His Ser Lys Ser Ala Ser Leu 
        195                 200                 205             


Leu Phe Gly Met Arg Asn Ser Ala Ala Ser Asp Glu Asp Ser Ser Trp 
    210                 215                 220                 


Ala Xaa Leu Ser Gln Gly Ser Pro Ser Tyr Gly Ser Pro Glu Asp Xaa 
225                 230                 235                 240 


Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Xaa Asp Ser Asp Leu Pro 
                245                 250                 255     


Ala Gly Trp Met Arg Val Gln Asp Xaa Ser Gly Xaa Tyr Tyr Trp His 
            260                 265                 270         


Ile Pro Xaa Gly Xaa Xaa Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro 
        275                 280                 285             


Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu Xaa Trp Xaa Gly 
    290                 295                 300                 


Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu 
305                 310                 315                 320 


Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu 
                325                 330                 335     


Gly Xaa Leu Xaa Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro 
            340                 345                 350         


Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Xaa Asn Pro Gly Ile Lys 
        355                 360                 365             


Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Xaa Glu Glu Glu 
    370                 375                 380                 


Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln 
385                 390                 395                 400 


Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp 
                405                 410                 415     


Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Xaa Leu Lys 
            420                 425                 430         


Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile 
        435                 440                 445             


Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly Ser Asn Arg Asp 
    450                 455                 460                 


Phe Ala Tyr Val Ala Arg Asp Lys Leu Xaa Gln Met Leu Lys Cys His 
465                 470                 475                 480 


Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Xaa Ser Leu His 
                485                 490                 495     


Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu 
            500                 505                 510         


Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe 
        515                 520                 525             


Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln 
    530                 535                 540                 


Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp 
545                 550                 555                 560 


Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu 
                565                 570                 575     


Gln Trp Xaa Pro Ser His Val Ser Val Ala Pro Ala Xaa Leu Xaa Ile 
            580                 585                 590         


Leu His Gln Gln Xaa Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe 
        595                 600                 605             


Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Xaa Phe Ala Phe Ile 
    610                 615                 620                 


Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu 
625                 630                 635                 640 


Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu 
                645                 650                 655     


Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Xaa Ser Cys 
            660                 665                 670         


Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Xaa 
        675                 680                 685             


Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg 
    690                 695                 700                 


Leu Gly Ala His Xaa Pro 
705                 710 


<210> 2507
<211> 710
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<400> 2507
Met Ser Val Pro Ser Ser Leu Ser Gln Ser Ala Ile Asn Ala Asn Ser 
1               5                   10                  15      


His Gly Gly Pro Ala Leu Ser Leu Pro Leu Pro Leu His Ala Ala His 
            20                  25                  30          


Asn Gln Leu Leu Asn Ala Lys Leu Gln Ala Xaa Ala Val Gly Pro Lys 
        35                  40                  45              


Asp Leu Arg Ser Ala Met Gly Glu Gly Gly Gly Pro Glu Pro Gly Pro 
    50                  55                  60                  


Ala Asn Ala Lys Trp Leu Lys Glu Gly Gln Asn Gln Leu Arg Arg Ala 
65                  70                  75                  80  


Ala Xaa Ala His Arg Asp Gln Asn Arg Asn Val Xaa Leu Xaa Leu Ala 
                85                  90                  95      


Glu Glu Ala Ser Gln Glu Pro Glu Met Ala Pro Leu Gly Pro Lys Gly 
            100                 105                 110         


Leu Ile His Leu Tyr Ser Glu Leu Glu Leu Ser Ala His Asn Ala Ala 
        115                 120                 125             


Asn Arg Gly Leu Arg Gly Pro Gly Leu Ile Ile Ser Xaa Gln Glu Gln 
    130                 135                 140                 


Gly Pro Asp Glu Gly Glu Glu Lys Ala Ala Gly Glu Ala Glu Glu Glu 
145                 150                 155                 160 


Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu Glu Asp Leu Ser Ser Pro 
                165                 170                 175     


Pro Gly Leu Pro Glu Pro Leu Glu Ser Val Glu Ala Pro Pro Arg Pro 
            180                 185                 190         


Gln Ala Leu Xaa Asp Gly Pro Arg Glu His Ser Lys Ser Ala Ser Leu 
        195                 200                 205             


Leu Phe Gly Met Arg Asn Ser Ala Ala Ser Asp Glu Asp Ser Ser Trp 
    210                 215                 220                 


Ala Xaa Leu Ser Gln Gly Ser Pro Ser Tyr Gly Ser Pro Glu Asp Xaa 
225                 230                 235                 240 


Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Xaa Asp Ser Asp Leu Pro 
                245                 250                 255     


Ala Gly Trp Met Arg Val Gln Asp Xaa Ser Gly Xaa Tyr Tyr Trp His 
            260                 265                 270         


Ile Pro Xaa Gly Xaa Xaa Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro 
        275                 280                 285             


Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu Xaa Trp Xaa Gly 
    290                 295                 300                 


Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu 
305                 310                 315                 320 


Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu 
                325                 330                 335     


Gly Xaa Leu Xaa Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro 
            340                 345                 350         


Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Xaa Asn Pro Gly Ile Lys 
        355                 360                 365             


Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Xaa Glu Glu Glu 
    370                 375                 380                 


Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln 
385                 390                 395                 400 


Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp 
                405                 410                 415     


Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Xaa Leu Lys 
            420                 425                 430         


Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile 
        435                 440                 445             


Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly Arg Glu Arg Asp 
    450                 455                 460                 


Phe Ala Tyr Val Ala Arg Asp Lys Leu Xaa Gln Met Leu Lys Cys His 
465                 470                 475                 480 


Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Xaa Ser Leu His 
                485                 490                 495     


Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu 
            500                 505                 510         


Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe 
        515                 520                 525             


Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln 
    530                 535                 540                 


Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp 
545                 550                 555                 560 


Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu 
                565                 570                 575     


Gln Trp Xaa Pro Ser His Val Ser Val Ala Pro Ala Xaa Leu Xaa Ile 
            580                 585                 590         


Leu His Gln Gln Xaa Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe 
        595                 600                 605             


Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Xaa Phe Ala Phe Ile 
    610                 615                 620                 


Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu 
625                 630                 635                 640 


Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu 
                645                 650                 655     


Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Xaa Ser Cys 
            660                 665                 670         


Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Xaa 
        675                 680                 685             


Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg 
    690                 695                 700                 


Leu Gly Ala His Xaa Pro 
705                 710 


<210> 2508
<211> 475
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<400> 2508
Met Xaa Gln Met Arg Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Xaa 
1               5                   10                  15      


Asp Ser Asp Leu Pro Ala Gly Trp Met Arg Val Gln Asp Xaa Ser Gly 
            20                  25                  30          


Xaa Tyr Tyr Trp His Ile Pro Xaa Gly Xaa Xaa Gln Trp Glu Pro Pro 
        35                  40                  45              


Gly Arg Ala Ser Pro Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln 
    50                  55                  60                  


Leu Xaa Trp Xaa Gly Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu 
65                  70                  75                  80  


Phe Trp Lys Asp Glu Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu 
                85                  90                  95      


Lys Glu Pro Glu Glu Gly Xaa Leu Xaa Phe Pro Ala Gln Ser Leu Ser 
            100                 105                 110         


Pro Glu Pro Leu Pro Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Xaa 
        115                 120                 125             


Asn Pro Gly Ile Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu 
    130                 135                 140                 


Met Xaa Glu Glu Glu Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn 
145                 150                 155                 160 


Asn Cys Ile Arg Gln Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro 
                165                 170                 175     


Met Ser Gly Gly Trp Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu 
            180                 185                 190         


Asp Glu Xaa Leu Lys Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His 
        195                 200                 205             


Ala Gln Pro Ile Ile Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser 
    210                 215                 220                 


Gly Arg Glu Arg Asp Phe Ala Tyr Val Ala Arg Asp Lys Leu Xaa Gln 
225                 230                 235                 240 


Met Leu Lys Cys His Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile 
                245                 250                 255     


Ala Xaa Ser Leu His Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg 
            260                 265                 270         


Asn Ala Arg Cys Leu Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu 
        275                 280                 285             


Val Asp Val Pro Phe Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu 
    290                 295                 300                 


Val Gln Lys Phe Gln Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys 
305                 310                 315                 320 


Pro Val Gly Val Asp Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser 
                325                 330                 335     


Ser Ser Ser Arg Glu Gln Trp Xaa Pro Ser His Val Ser Val Ala Pro 
            340                 345                 350         


Ala Xaa Leu Xaa Ile Leu His Gln Gln Xaa Glu Ala Val Leu Gly Glu 
        355                 360                 365             


Cys Arg Val Arg Phe Leu Ser Phe Leu Ala Val Gly Arg Asp Val His 
    370                 375                 380                 


Xaa Phe Ala Phe Ile Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His 
385                 390                 395                 400 


Met Phe Trp Cys Glu Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln 
                405                 410                 415     


Ala Ala Cys Met Leu Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln 
            420                 425                 430         


Ala Ser Xaa Ser Cys Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg 
        435                 440                 445             


Arg Val Gly Trp Xaa Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser 
    450                 455                 460                 


Leu Lys Pro Lys Arg Leu Gly Ala His Xaa Pro 
465                 470                 475 


<210> 2509
<211> 475
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<400> 2509
Met Xaa Gln Met Arg Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Xaa 
1               5                   10                  15      


Asp Ser Asp Leu Pro Ala Gly Trp Met Arg Val Gln Asp Xaa Ser Gly 
            20                  25                  30          


Xaa Tyr Tyr Trp His Ile Pro Xaa Gly Xaa Xaa Gln Trp Glu Pro Pro 
        35                  40                  45              


Gly Arg Ala Ser Pro Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln 
    50                  55                  60                  


Leu Xaa Trp Xaa Gly Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu 
65                  70                  75                  80  


Phe Trp Lys Asp Glu Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu 
                85                  90                  95      


Lys Glu Pro Glu Glu Gly Xaa Leu Xaa Phe Pro Ala Gln Ser Leu Ser 
            100                 105                 110         


Pro Glu Pro Leu Pro Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Xaa 
        115                 120                 125             


Asn Pro Gly Ile Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu 
    130                 135                 140                 


Met Xaa Glu Glu Glu Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn 
145                 150                 155                 160 


Asn Cys Ile Arg Gln Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro 
                165                 170                 175     


Met Ser Gly Gly Trp Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu 
            180                 185                 190         


Asp Glu Xaa Leu Lys Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His 
        195                 200                 205             


Ala Gln Pro Ile Ile Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser 
    210                 215                 220                 


Gly Ser Asn Arg Asp Phe Ala Tyr Val Ala Arg Asp Lys Leu Xaa Gln 
225                 230                 235                 240 


Met Leu Lys Cys His Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile 
                245                 250                 255     


Ala Xaa Ser Leu His Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg 
            260                 265                 270         


Asn Ala Arg Cys Leu Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu 
        275                 280                 285             


Val Asp Val Pro Phe Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu 
    290                 295                 300                 


Val Gln Lys Phe Gln Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys 
305                 310                 315                 320 


Pro Val Gly Val Asp Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser 
                325                 330                 335     


Ser Ser Ser Arg Glu Gln Trp Xaa Pro Ser His Val Ser Val Ala Pro 
            340                 345                 350         


Ala Xaa Leu Xaa Ile Leu His Gln Gln Xaa Glu Ala Val Leu Gly Glu 
        355                 360                 365             


Cys Arg Val Arg Phe Leu Ser Phe Leu Ala Val Gly Arg Asp Val His 
    370                 375                 380                 


Xaa Phe Ala Phe Ile Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His 
385                 390                 395                 400 


Met Phe Trp Cys Glu Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln 
                405                 410                 415     


Ala Ala Cys Met Leu Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln 
            420                 425                 430         


Ala Ser Xaa Ser Cys Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg 
        435                 440                 445             


Arg Val Gly Trp Xaa Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser 
    450                 455                 460                 


Leu Lys Pro Lys Arg Leu Gly Ala His Xaa Pro 
465                 470                 475 


<210> 2510
<211> 666
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<400> 2510
Met Gly Glu Ser Ser Glu Asp Ile Asp Gln Met Phe Ser Xaa Leu Leu 
1               5                   10                  15      


Gly Glu Met Asp Leu Leu Xaa Gln Ser Leu Gly Val Asp Xaa Leu Pro 
            20                  25                  30          


Pro Pro Asp Pro Asn Pro Pro Arg Ala Glu Phe Asn Tyr Ser Val Gly 
        35                  40                  45              


Phe Lys Asp Leu Asn Glu Ser Leu Asn Ala Leu Glu Asp Gln Asp Leu 
    50                  55                  60                  


Asp Ala Leu Met Ala Asp Leu Val Ala Asp Ile Ser Glu Ala Glu Gln 
65                  70                  75                  80  


Arg Xaa Ile Gln Ala Gln Lys Glu Ser Leu Gln Asn Gln His His Ser 
                85                  90                  95      


Ala Ser Leu Gln Ala Ser Ile Phe Ser Gly Ala Ala Ser Leu Gly Tyr 
            100                 105                 110         


Gly Xaa Asn Val Ala Ala Xaa Gly Ile Ser Gln Tyr Glu Asp Asp Leu 
        115                 120                 125             


Pro Pro Pro Pro Ala Asp Pro Val Leu Asp Leu Pro Leu Pro Pro Pro 
    130                 135                 140                 


Pro Pro Glu Pro Leu Ser Gln Glu Glu Glu Glu Ala Gln Ala Lys Ala 
145                 150                 155                 160 


Asp Lys Ile Lys Leu Ala Leu Glu Lys Leu Lys Glu Ala Lys Val Lys 
                165                 170                 175     


Lys Leu Val Val Lys Val His Met Asn Asp Asn Ser Xaa Lys Ser Leu 
            180                 185                 190         


Met Val Asp Glu Arg Gln Leu Ala Arg Asp Val Leu Asp Asn Leu Phe 
        195                 200                 205             


Glu Lys Xaa His Cys Asp Cys Asn Val Asp Trp Cys Leu Tyr Glu Ile 
    210                 215                 220                 


Tyr Pro Glu Leu Gln Ile Glu Arg Phe Phe Glu Asp His Glu Asn Val 
225                 230                 235                 240 


Val Glu Val Leu Ser Asp Trp Xaa Arg Asp Xaa Glu Asn Lys Ile Leu 
                245                 250                 255     


Phe Leu Glu Lys Glu Glu Lys Tyr Ala Val Phe Lys Asn Pro Gln Asn 
            260                 265                 270         


Phe Tyr Leu Asp Asn Arg Gly Lys Lys Glu Ser Lys Glu Xaa Asn Glu 
        275                 280                 285             


Lys Met Asn Ala Lys Asn Lys Glu Ser Leu Leu Glu Glu Ser Phe Cys 
    290                 295                 300                 


Gly Xaa Ser Ile Ile Val Pro Glu Leu Glu Gly Ala Leu Tyr Leu Lys 
305                 310                 315                 320 


Glu Asp Gly Lys Lys Ser Trp Lys Arg Arg Tyr Phe Leu Leu Arg Ala 
                325                 330                 335     


Ser Gly Ile Tyr Tyr Val Pro Lys Gly Lys Xaa Lys Xaa Ser Arg Asp 
            340                 345                 350         


Leu Ala Cys Phe Ile Gln Phe Glu Asn Val Asn Ile Tyr Tyr Gly Xaa 
        355                 360                 365             


Gln His Lys Met Lys Tyr Lys Ala Pro Xaa Asp Tyr Cys Phe Val Leu 
    370                 375                 380                 


Lys His Pro Gln Ile Gln Lys Glu Ser Gln Tyr Ile Lys Tyr Leu Cys 
385                 390                 395                 400 


Cys Asp Asp Xaa Arg Xaa Leu Asn Gln Trp Val Met Gly Ile Arg Ile 
                405                 410                 415     


Ala Lys Tyr Gly Lys Xaa Leu Tyr Asp Asn Tyr Gln Arg Ala Val Ala 
            420                 425                 430         


Lys Ala Gly Leu Ala Ser Arg Trp Xaa Asn Leu Gly Xaa Val Asn Ala 
        435                 440                 445             


Ala Ala Pro Ala Gln Pro Ser Xaa Gly Pro Lys Xaa Gly Xaa Xaa Gln 
    450                 455                 460                 


Pro Asn Gly Gln Ile Pro Gln Ala Xaa His Ser Val Ser Ala Val Leu 
465                 470                 475                 480 


Gln Glu Ala Gln Arg His Ala Glu Xaa Ser Lys Asp Lys Lys Pro Ala 
                485                 490                 495     


Leu Gly Asn His His Asp Pro Ala Val Pro Arg Ala Pro His Ala Pro 
            500                 505                 510         


Lys Ser Ser Leu Pro Pro Pro Pro Pro Val Arg Arg Ser Ser Asp Xaa 
        515                 520                 525             


Ser Gly Ser Pro Ala Xaa Pro Leu Lys Ala Lys Gly Xaa Gly Gly Gly 
    530                 535                 540                 


Gly Leu Pro Ala Pro Pro Asp Asp Phe Leu Pro Pro Pro Pro Pro Pro 
545                 550                 555                 560 


Pro Pro Leu Asp Asp Pro Glu Leu Pro Pro Pro Pro Pro Asp Phe Met 
                565                 570                 575     


Glu Pro Pro Pro Asp Phe Val Pro Pro Pro Pro Pro Ser Tyr Ala Gly 
            580                 585                 590         


Ile Ala Gly Ser Glu Leu Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro 
        595                 600                 605             


Ala Pro Ala Pro Val Pro Asp Ser Ala Arg Pro Pro Pro Ala Val Ala 
    610                 615                 620                 


Lys Arg Pro Pro Val Pro Pro Lys Arg Gln Glu Asn Pro Gly His Pro 
625                 630                 635                 640 


Gly Gly Ala Gly Gly Gly Glu Gln Asp Phe Met Ser Asp Leu Met Lys 
                645                 650                 655     


Ala Leu Gln Lys Lys Arg Gly Asn Val Ser 
            660                 665     


<210> 2511
<211> 172
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 2511
Met Gly Glu Ser Ser Glu Asp Ile Asp Gln Met Phe Ser Xaa Leu Leu 
1               5                   10                  15      


Gly Glu Met Asp Leu Leu Xaa Gln Ser Leu Gly Val Asp Xaa Leu Pro 
            20                  25                  30          


Pro Pro Asp Pro Asn Pro Pro Arg Ala Glu Phe Asn Tyr Ser Val Gly 
        35                  40                  45              


Phe Lys Asp Leu Asn Glu Ser Leu Asn Ala Leu Glu Asp Gln Asp Leu 
    50                  55                  60                  


Asp Ala Leu Met Ala Asp Leu Val Ala Asp Ile Ser Glu Ala Glu Gln 
65                  70                  75                  80  


Arg Xaa Ile Gln Ala Gln Lys Glu Ser Leu Gln Asn Gln His His Ser 
                85                  90                  95      


Ala Ser Leu Gln Ala Ser Ile Phe Ser Gly Ala Ala Ser Leu Gly Tyr 
            100                 105                 110         


Gly Xaa Asn Val Ala Ala Xaa Gly Ile Ser Gln Tyr Glu Asp Asp Leu 
        115                 120                 125             


Pro Pro Pro Pro Ala Asp Pro Val Leu Asp Leu Pro Leu Pro Pro Pro 
    130                 135                 140                 


Pro Pro Glu Pro Leu Ser Gln Val Ser Met Trp Asp Gln Arg Trp Gln 
145                 150                 155                 160 


Asp His Gln Pro Leu Leu Pro Ile Xaa Asp Val Pro 
                165                 170         


<210> 2512
<211> 87
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<400> 2512
Met Ala Glu Arg Lys Asn Ala Lys Ala Leu Ala Cys Ser Ser Leu Gln 
1               5                   10                  15      


Glu Arg Ala Asn Val Asn Leu Asp Val Pro Leu Gln Val Asp Phe Pro 
            20                  25                  30          


Xaa Pro Lys Xaa Glu Leu Val Gln Lys Phe His Val Gln Tyr Leu Gly 
        35                  40                  45              


Met Leu Pro Val Asp Lys Pro Val Gly Met Asp Ile Leu Asn Ser Ala 
    50                  55                  60                  


Ile Glu Asn Leu Met Xaa Ser Ser Asn Lys Glu Asp Trp Leu Ser Val 
65                  70                  75                  80  


Asn Met Asn Val Ala Asp Ala 
                85          


<210> 2513
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<400> 2513
Met Ala Glu Arg Lys Asn Ala Lys Ala Leu Ala Cys Ser Ser Leu Gln 
1               5                   10                  15      


Glu Arg Ala Asn Val Asn Leu Asp Val Pro Leu Gln Val Asp Phe Pro 
            20                  25                  30          


Xaa Pro Lys Xaa Glu Leu Val Gln Lys Phe His Val Gln Tyr Leu Gly 
        35                  40                  45              


Met Leu Pro Val Asp Lys Pro Val Gly Met Asp Ile Leu Asn Ser Ala 
    50                  55                  60                  


Ile Glu Asn Leu Met Xaa Ser Ser Asn Lys Glu Asp Trp Leu Ser Val 
65                  70                  75                  80  


Asn Met Asn Val Ala Asp Ala Xaa Val Xaa Val Ile Ser Glu Lys 
                85                  90                  95  


<210> 2514
<211> 102
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<400> 2514
Met Ala Glu Arg Lys Asn Ala Lys Ala Leu Ala Cys Ser Ser Leu Gln 
1               5                   10                  15      


Glu Arg Ala Asn Val Asn Leu Asp Val Pro Leu Gln Val Asp Phe Pro 
            20                  25                  30          


Xaa Pro Lys Xaa Glu Leu Val Gln Lys Phe His Val Gln Tyr Leu Gly 
        35                  40                  45              


Met Leu Pro Val Asp Lys Pro Val Gly Met Asp Ile Leu Asn Ser Ala 
    50                  55                  60                  


Ile Glu Asn Leu Met Xaa Ser Ser Asn Lys Glu Asp Trp Leu Ser Val 
65                  70                  75                  80  


Asn Met Asn Val Ala Asp Ala Xaa Val Xaa Val Ile Ser Glu Lys Asn 
                85                  90                  95      


Glu Glu Glu Val Leu Val 
            100         


<210> 2515
<211> 210
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<400> 2515
Met Ala Glu Arg Lys Asn Ala Lys Ala Leu Ala Cys Ser Ser Leu Gln 
1               5                   10                  15      


Glu Arg Ala Asn Val Asn Leu Asp Val Pro Leu Gln Val Asp Phe Pro 
            20                  25                  30          


Xaa Pro Lys Xaa Glu Leu Val Gln Lys Phe His Val Gln Tyr Leu Gly 
        35                  40                  45              


Met Leu Pro Val Asp Lys Pro Val Gly Met Asp Ile Leu Asn Ser Ala 
    50                  55                  60                  


Ile Glu Asn Leu Met Xaa Ser Ser Asn Lys Glu Asp Trp Leu Ser Val 
65                  70                  75                  80  


Asn Met Asn Val Ala Asp Ala Xaa Val Xaa Val Ile Ser Glu Lys Asn 
                85                  90                  95      


Glu Glu Glu Val Leu Val Glu Cys Arg Val Arg Phe Leu Ser Phe Met 
            100                 105                 110         


Gly Val Gly Lys Asp Val His Xaa Phe Ala Phe Ile Met Asp Xaa Gly 
        115                 120                 125             


Asn Gln Arg Phe Glu Cys His Val Phe Trp Cys Glu Pro Asn Ala Gly 
    130                 135                 140                 


Asn Val Ser Glu Ala Val Gln Ala Ala Cys Met Leu Arg Tyr Gln Lys 
145                 150                 155                 160 


Cys Leu Val Ala Arg Pro Pro Ser Gln Lys Val Arg Pro Pro Pro Pro 
                165                 170                 175     


Pro Ala Asp Ser Val Xaa Arg Arg Val Xaa Xaa Asn Val Lys Arg Gly 
            180                 185                 190         


Val Leu Ser Leu Ile Asp Xaa Leu Lys Gln Lys Arg Pro Val Xaa Glu 
        195                 200                 205             


Met Pro 
    210 


<210> 2516
<211> 26
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<400> 2516
Met Ala Ser Ser Gly Xaa Xaa Asp Val Xaa Asn Arg Asn Ser Pro Ala 
1               5                   10                  15      


Xaa Pro Pro Asn Xaa Leu Asn Leu Arg Ser 
            20                  25      


<210> 2517
<211> 140
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<400> 2517
Met Ala Ser Ser Gly Xaa Xaa Asp Val Xaa Asn Arg Asn Ser Pro Ala 
1               5                   10                  15      


Xaa Pro Pro Asn Xaa Leu Asn Leu Arg Ser Ser His Asn Glu Leu Leu 
            20                  25                  30          


Asn Ala Glu Ile Lys His Xaa Glu Xaa Lys Asn Ser Xaa Pro Pro Lys 
        35                  40                  45              


Cys Arg Lys Lys Tyr Ala Leu Xaa Asn Ile Gln Ala Ala Met Gly Leu 
    50                  55                  60                  


Ser Asp Pro Ala Ala Gln Pro Leu Leu Gly Asn Gly Ser Ala Asn Ile 
65                  70                  75                  80  


Lys Leu Val Lys Asn Gly Glu Asn Gln Leu Arg Lys Ala Ala Glu Gln 
                85                  90                  95      


Gly Gln Gln Asp Pro Asn Lys Asn Leu Ser Pro Xaa Ala Val Ile Asn 
            100                 105                 110         


Ile Xaa Ser Glu Lys Leu Glu Gly Lys Glu Pro His Pro Gln Asp Ser 
        115                 120                 125             


Ser Ser Cys Glu Ile Leu Pro Ser Gln Pro Arg Arg 
    130                 135                 140 


<210> 2518
<211> 10
<212> PRT
<213> Homo sapiens

<400> 2518
Met Ser Glu Val Leu Pro Ala Asp Ser Gly 
1               5                   10  


<210> 2519
<211> 27
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 2519
Met Ser Glu Val Leu Pro Ala Asp Ser Gly Val Asp Xaa Leu Ala Val 
1               5                   10                  15      


Phe Met Ala Ser Ser Gly Xaa Xaa Asp Val Xaa 
            20                  25          


<210> 2520
<211> 68
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<400> 2520
Met Ser Glu Val Leu Pro Ala Asp Ser Gly Val Asp Xaa Leu Ala Val 
1               5                   10                  15      


Phe Met Ala Ser Ser Gly Xaa Xaa Asp Val Xaa Asn Arg Asn Ser Pro 
            20                  25                  30          


Ala Xaa Pro Pro Asn Xaa Leu Asn Leu Arg Ser Ser His Asn Glu Leu 
        35                  40                  45              


Leu Asn Ala Glu Ile Lys His Xaa Glu Xaa Lys Asn Ser Xaa Pro Pro 
    50                  55                  60                  


Lys Cys Arg Lys 
65              


<210> 2521
<211> 736
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<400> 2521
Met Ser Glu Val Leu Pro Ala Asp Ser Gly Val Asp Xaa Leu Ala Val 
1               5                   10                  15      


Phe Met Ala Ser Ser Gly Xaa Xaa Asp Val Xaa Asn Arg Asn Ser Pro 
            20                  25                  30          


Ala Xaa Pro Pro Asn Xaa Leu Asn Leu Arg Ser Ser His Asn Glu Leu 
        35                  40                  45              


Leu Asn Ala Glu Ile Lys His Xaa Glu Xaa Lys Asn Ser Xaa Pro Pro 
    50                  55                  60                  


Lys Cys Arg Lys Lys Tyr Ala Leu Xaa Asn Ile Gln Ala Ala Met Gly 
65                  70                  75                  80  


Leu Ser Asp Pro Ala Ala Gln Pro Leu Leu Gly Asn Gly Ser Ala Asn 
                85                  90                  95      


Ile Lys Leu Val Lys Asn Gly Glu Asn Gln Leu Arg Lys Ala Ala Glu 
            100                 105                 110         


Gln Gly Gln Gln Asp Pro Asn Lys Asn Leu Ser Pro Xaa Ala Val Ile 
        115                 120                 125             


Asn Ile Xaa Ser Glu Lys Leu Glu Gly Lys Glu Pro His Pro Gln Asp 
    130                 135                 140                 


Ser Ser Ser Cys Glu Ile Leu Pro Ser Gln Pro Arg Arg Xaa Lys Ser 
145                 150                 155                 160 


Phe Leu Asn Tyr Tyr Ala Asp Leu Glu Xaa Ser Ala Arg Glu Leu Glu 
                165                 170                 175     


Gln Asn Arg Gly Asn His His Gly Xaa Ala Glu Glu Lys Ser Gln Pro 
            180                 185                 190         


Val Gln Gly Gln Ala Ser Xaa Ile Ile Gly Asn Gly Asp Leu Leu Leu 
        195                 200                 205             


Gln Lys Pro Asn Arg Pro Gln Ser Ser Pro Glu Asp Gly Gln Val Ala 
    210                 215                 220                 


Xaa Val Ser Ser Ser Pro Glu Xaa Lys Lys Asp His Pro Lys Xaa Gly 
225                 230                 235                 240 


Ala Lys Xaa Asp Cys Ala Leu His Arg Ile Gln Asn Leu Ala Pro Ser 
                245                 250                 255     


Asp Glu Glu Ser Ser Trp Xaa Xaa Leu Ser Gln Asp Ser Ala Ser Pro 
            260                 265                 270         


Ser Ser Pro Asp Glu Xaa Asp Ile Trp Ser Asp His Ser Phe Gln Xaa 
        275                 280                 285             


Asp Pro Asp Leu Pro Pro Gly Trp Lys Arg Val Ser Asp Ile Ala Gly 
    290                 295                 300                 


Xaa Tyr Tyr Trp His Ile Pro Xaa Gly Xaa Xaa Gln Trp Glu Arg Pro 
305                 310                 315                 320 


Val Ser Ile Pro Ala Asp Leu Gln Gly Ser Arg Lys Gly Ser Leu Ser 
                325                 330                 335     


Ser Val Xaa Pro Ser Pro Xaa Pro Glu Asn Glu Asp Leu His Ala Ala 
            340                 345                 350         


Xaa Val Asn Pro Asp Pro Ser Leu Lys Glu Phe Glu Gly Ala Xaa Leu 
        355                 360                 365             


Arg Tyr Ala Ser Leu Lys Leu Arg Asn Ala Pro His Pro Asp Asp Asp 
    370                 375                 380                 


Asp Ser Cys Ser Ile Asn Ser Asp Pro Glu Ala Lys Cys Phe Ala Val 
385                 390                 395                 400 


Arg Ser Leu Gly Trp Val Glu Met Ala Glu Glu Asp Leu Ala Pro Gly 
                405                 410                 415     


Lys Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln Leu Ser Tyr Cys 
            420                 425                 430         


Lys Asn Asp Ile Arg Asp Xaa Val Gly Ile Trp Gly Glu Gly Lys Asp 
        435                 440                 445             


Met Tyr Leu Ile Leu Glu Asn Asp Met Leu Ser Leu Val Asp Pro Met 
    450                 455                 460                 


Asp Arg Ser Val Leu His Ser Gln Pro Ile Val Ser Ile Arg Val Trp 
465                 470                 475                 480 


Gly Val Gly Arg Asp Asn Gly Arg Asp Phe Ala Tyr Val Ala Arg Asp 
                485                 490                 495     


Lys Asp Xaa Arg Ile Leu Lys Cys His Val Phe Arg Cys Asp Xaa Pro 
            500                 505                 510         


Ala Lys Ala Ile Ala Xaa Ser Leu His Glu Ile Cys Ser Lys Ile Met 
        515                 520                 525             


Ala Glu Arg Lys Asn Ala Lys Ala Leu Ala Cys Ser Ser Leu Gln Glu 
    530                 535                 540                 


Arg Ala Asn Val Asn Leu Asp Val Pro Leu Gln Asp Phe Pro Xaa Pro 
545                 550                 555                 560 


Lys Xaa Glu Leu Val Gln Lys Phe His Val Gln Tyr Leu Gly Met Leu 
                565                 570                 575     


Pro Val Asp Lys Pro Val Gly Met Asp Ile Leu Asn Ser Ala Ile Glu 
            580                 585                 590         


Asn Leu Met Xaa Ser Ser Asn Lys Glu Asp Trp Leu Ser Val Asn Met 
        595                 600                 605             


Asn Val Ala Asp Ala Xaa Val Xaa Val Ile Ser Glu Lys Asn Glu Glu 
    610                 615                 620                 


Glu Val Leu Val Glu Cys Arg Val Arg Phe Leu Ser Phe Met Gly Val 
625                 630                 635                 640 


Gly Lys Asp Val His Xaa Phe Ala Phe Ile Met Asp Xaa Gly Asn Gln 
                645                 650                 655     


Arg Phe Glu Cys His Val Phe Trp Cys Glu Pro Asn Ala Gly Asn Val 
            660                 665                 670         


Ser Glu Ala Val Gln Ala Ala Cys Met Leu Arg Tyr Gln Lys Cys Leu 
        675                 680                 685             


Val Ala Arg Pro Pro Ser Gln Lys Val Arg Pro Pro Pro Pro Pro Ala 
    690                 695                 700                 


Asp Ser Val Xaa Arg Arg Val Xaa Xaa Asn Val Lys Arg Gly Val Leu 
705                 710                 715                 720 


Ser Leu Ile Asp Xaa Leu Lys Gln Lys Arg Pro Val Xaa Glu Met Pro 
                725                 730                 735     


<210> 2522
<211> 737
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<400> 2522
Met Ser Glu Val Leu Pro Ala Asp Ser Gly Val Asp Xaa Leu Ala Val 
1               5                   10                  15      


Phe Met Ala Ser Ser Gly Xaa Xaa Asp Val Xaa Asn Arg Asn Ser Pro 
            20                  25                  30          


Ala Xaa Pro Pro Asn Xaa Leu Asn Leu Arg Ser Ser His Asn Glu Leu 
        35                  40                  45              


Leu Asn Ala Glu Ile Lys His Xaa Glu Xaa Lys Asn Ser Xaa Pro Pro 
    50                  55                  60                  


Lys Cys Arg Lys Lys Tyr Ala Leu Xaa Asn Ile Gln Ala Ala Met Gly 
65                  70                  75                  80  


Leu Ser Asp Pro Ala Ala Gln Pro Leu Leu Gly Asn Gly Ser Ala Asn 
                85                  90                  95      


Ile Lys Leu Val Lys Asn Gly Glu Asn Gln Leu Arg Lys Ala Ala Glu 
            100                 105                 110         


Gln Gly Gln Gln Asp Pro Asn Lys Asn Leu Ser Pro Xaa Ala Val Ile 
        115                 120                 125             


Asn Ile Xaa Ser Glu Lys Leu Glu Gly Lys Glu Pro His Pro Gln Asp 
    130                 135                 140                 


Ser Ser Ser Cys Glu Ile Leu Pro Ser Gln Pro Arg Arg Xaa Lys Ser 
145                 150                 155                 160 


Phe Leu Asn Tyr Tyr Ala Asp Leu Glu Xaa Ser Ala Arg Glu Leu Glu 
                165                 170                 175     


Gln Asn Arg Gly Asn His His Gly Xaa Ala Glu Glu Lys Ser Gln Pro 
            180                 185                 190         


Val Gln Gly Gln Ala Ser Xaa Ile Ile Gly Asn Gly Asp Leu Leu Leu 
        195                 200                 205             


Gln Lys Pro Asn Arg Pro Gln Ser Ser Pro Glu Asp Gly Gln Val Ala 
    210                 215                 220                 


Xaa Val Ser Ser Ser Pro Glu Xaa Lys Lys Asp His Pro Lys Xaa Gly 
225                 230                 235                 240 


Ala Lys Xaa Asp Cys Ala Leu His Arg Ile Gln Asn Leu Ala Pro Ser 
                245                 250                 255     


Asp Glu Glu Ser Ser Trp Xaa Xaa Leu Ser Gln Asp Ser Ala Ser Pro 
            260                 265                 270         


Ser Ser Pro Asp Glu Xaa Asp Ile Trp Ser Asp His Ser Phe Gln Xaa 
        275                 280                 285             


Asp Pro Asp Leu Pro Pro Gly Trp Lys Arg Val Ser Asp Ile Ala Gly 
    290                 295                 300                 


Xaa Tyr Tyr Trp His Ile Pro Xaa Gly Xaa Xaa Gln Trp Glu Arg Pro 
305                 310                 315                 320 


Val Ser Ile Pro Ala Asp Leu Gln Gly Ser Arg Lys Gly Ser Leu Ser 
                325                 330                 335     


Ser Val Xaa Pro Ser Pro Xaa Pro Glu Asn Glu Asp Leu His Ala Ala 
            340                 345                 350         


Xaa Val Asn Pro Asp Pro Ser Leu Lys Glu Phe Glu Gly Ala Xaa Leu 
        355                 360                 365             


Arg Tyr Ala Ser Leu Lys Leu Arg Asn Ala Pro His Pro Asp Asp Asp 
    370                 375                 380                 


Asp Ser Cys Ser Ile Asn Ser Asp Pro Glu Ala Lys Cys Phe Ala Val 
385                 390                 395                 400 


Arg Ser Leu Gly Trp Val Glu Met Ala Glu Glu Asp Leu Ala Pro Gly 
                405                 410                 415     


Lys Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln Leu Ser Tyr Cys 
            420                 425                 430         


Lys Asn Asp Ile Arg Asp Xaa Val Gly Ile Trp Gly Glu Gly Lys Asp 
        435                 440                 445             


Met Tyr Leu Ile Leu Glu Asn Asp Met Leu Ser Leu Val Asp Pro Met 
    450                 455                 460                 


Asp Arg Ser Val Leu His Ser Gln Pro Ile Val Ser Ile Arg Val Trp 
465                 470                 475                 480 


Gly Val Gly Arg Asp Asn Gly Arg Asp Phe Ala Tyr Val Ala Arg Asp 
                485                 490                 495     


Lys Asp Xaa Arg Ile Leu Lys Cys His Val Phe Arg Cys Asp Xaa Pro 
            500                 505                 510         


Ala Lys Ala Ile Ala Xaa Ser Leu His Glu Ile Cys Ser Lys Ile Met 
        515                 520                 525             


Ala Glu Arg Lys Asn Ala Lys Ala Leu Ala Cys Ser Ser Leu Gln Glu 
    530                 535                 540                 


Arg Ala Asn Val Asn Leu Asp Val Pro Leu Gln Val Asp Phe Pro Xaa 
545                 550                 555                 560 


Pro Lys Xaa Glu Leu Val Gln Lys Phe His Val Gln Tyr Leu Gly Met 
                565                 570                 575     


Leu Pro Val Asp Lys Pro Val Gly Met Asp Ile Leu Asn Ser Ala Ile 
            580                 585                 590         


Glu Asn Leu Met Xaa Ser Ser Asn Lys Glu Asp Trp Leu Ser Val Asn 
        595                 600                 605             


Met Asn Val Ala Asp Ala Xaa Val Xaa Val Ile Ser Glu Lys Asn Glu 
    610                 615                 620                 


Glu Glu Val Leu Val Glu Cys Arg Val Arg Phe Leu Ser Phe Met Gly 
625                 630                 635                 640 


Val Gly Lys Asp Val His Xaa Phe Ala Phe Ile Met Asp Xaa Gly Asn 
                645                 650                 655     


Gln Arg Phe Glu Cys His Val Phe Trp Cys Glu Pro Asn Ala Gly Asn 
            660                 665                 670         


Val Ser Glu Ala Val Gln Ala Ala Cys Met Leu Arg Tyr Gln Lys Cys 
        675                 680                 685             


Leu Val Ala Arg Pro Pro Ser Gln Lys Val Arg Pro Pro Pro Pro Pro 
    690                 695                 700                 


Ala Asp Ser Val Xaa Arg Arg Val Xaa Xaa Asn Val Lys Arg Gly Val 
705                 710                 715                 720 


Leu Ser Leu Ile Asp Xaa Leu Lys Gln Lys Arg Pro Val Xaa Glu Met 
                725                 730                 735     


Pro 
    


<210> 2523
<211> 758
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<400> 2523
Met Ser Glu Val Leu Pro Ala Asp Ser Gly Val Asp Xaa Leu Ala Val 
1               5                   10                  15      


Phe Met Ala Ser Ser Gly Xaa Xaa Asp Val Xaa Asn Arg Asn Ser Pro 
            20                  25                  30          


Ala Xaa Pro Pro Asn Xaa Leu Asn Leu Arg Ser Ser His Asn Glu Leu 
        35                  40                  45              


Leu Asn Ala Glu Ile Lys His Xaa Glu Xaa Lys Asn Ser Xaa Pro Pro 
    50                  55                  60                  


Lys Cys Arg Lys Lys Tyr Ala Leu Xaa Asn Ile Gln Ala Ala Met Gly 
65                  70                  75                  80  


Leu Ser Asp Pro Ala Ala Gln Pro Leu Leu Gly Asn Gly Ser Ala Asn 
                85                  90                  95      


Ile Lys Leu Val Lys Asn Gly Glu Asn Gln Leu Arg Lys Ala Ala Glu 
            100                 105                 110         


Gln Gly Gln Gln Asp Pro Asn Lys Asn Leu Ser Pro Xaa Ala Val Ile 
        115                 120                 125             


Asn Ile Xaa Ser Glu Lys Leu Glu Gly Lys Glu Pro His Pro Gln Asp 
    130                 135                 140                 


Ser Ser Ser Cys Glu Ile Leu Pro Ser Gln Pro Arg Arg Xaa Lys Ser 
145                 150                 155                 160 


Phe Leu Asn Tyr Tyr Ala Asp Leu Glu Xaa Ser Ala Arg Glu Leu Glu 
                165                 170                 175     


Gln Asn Arg Gly Asn His His Gly Xaa Ala Glu Glu Lys Ser Gln Pro 
            180                 185                 190         


Val Gln Gly Gln Ala Ser Xaa Ile Ile Gly Asn Gly Asp Leu Leu Leu 
        195                 200                 205             


Gln Lys Pro Asn Arg Pro Gln Ser Ser Pro Glu Asp Gly Gln Val Ala 
    210                 215                 220                 


Xaa Val Ser Ser Ser Pro Glu Xaa Lys Lys Asp His Pro Lys Xaa Gly 
225                 230                 235                 240 


Ala Lys Xaa Asp Cys Ala Leu His Arg Ile Gln Asn Leu Ala Pro Ser 
                245                 250                 255     


Asp Glu Glu Ser Ser Trp Xaa Xaa Leu Ser Gln Asp Ser Ala Ser Pro 
            260                 265                 270         


Ser Ser Pro Asp Glu Xaa Asp Ile Trp Ser Asp His Ser Phe Gln Xaa 
        275                 280                 285             


Asp Pro Asp Leu Pro Pro Gly Trp Lys Arg Val Ser Asp Ile Ala Gly 
    290                 295                 300                 


Xaa Tyr Tyr Trp His Ile Pro Xaa Gly Xaa Xaa Gln Trp Glu Arg Pro 
305                 310                 315                 320 


Val Ser Ile Pro Ala Asp Leu Gln Gly Ser Arg Lys Gly Ser Leu Ser 
                325                 330                 335     


Ser Val Xaa Pro Ser Pro Xaa Pro Glu Asn Glu Lys Gln Pro Trp Ser 
            340                 345                 350         


Asp Phe Ala Val Leu Asn Gly Gly Lys Ile Asn Ser Asp Ile Trp Lys 
        355                 360                 365             


Asp Leu His Ala Ala Xaa Val Asn Pro Asp Pro Ser Leu Lys Glu Phe 
    370                 375                 380                 


Glu Gly Ala Xaa Leu Arg Tyr Ala Ser Leu Lys Leu Arg Asn Ala Pro 
385                 390                 395                 400 


His Pro Asp Asp Asp Asp Ser Cys Ser Ile Asn Ser Asp Pro Glu Ala 
                405                 410                 415     


Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Ala Glu Glu 
            420                 425                 430         


Asp Leu Ala Pro Gly Lys Ser Ser Val Ala Val Asn Asn Cys Ile Arg 
        435                 440                 445             


Gln Leu Ser Tyr Cys Lys Asn Asp Ile Arg Asp Xaa Val Gly Ile Trp 
    450                 455                 460                 


Gly Glu Gly Lys Asp Met Tyr Leu Ile Leu Glu Asn Asp Met Leu Ser 
465                 470                 475                 480 


Leu Val Asp Pro Met Asp Arg Ser Val Leu His Ser Gln Pro Ile Val 
                485                 490                 495     


Ser Ile Arg Val Trp Gly Val Gly Arg Asp Asn Gly Arg Asp Phe Ala 
            500                 505                 510         


Tyr Val Ala Arg Asp Lys Asp Xaa Arg Ile Leu Lys Cys His Val Phe 
        515                 520                 525             


Arg Cys Asp Xaa Pro Ala Lys Ala Ile Ala Xaa Ser Leu His Glu Ile 
    530                 535                 540                 


Cys Ser Lys Ile Met Ala Glu Arg Lys Asn Ala Lys Ala Leu Ala Cys 
545                 550                 555                 560 


Ser Ser Leu Gln Glu Arg Ala Asn Val Asn Leu Asp Val Pro Leu Gln 
                565                 570                 575     


Val Asp Phe Pro Xaa Pro Lys Xaa Glu Leu Val Gln Lys Phe His Val 
            580                 585                 590         


Gln Tyr Leu Gly Met Leu Pro Val Asp Lys Pro Val Gly Met Asp Ile 
        595                 600                 605             


Leu Asn Ser Ala Ile Glu Asn Leu Met Xaa Ser Ser Asn Lys Glu Asp 
    610                 615                 620                 


Trp Leu Ser Val Asn Met Asn Val Ala Asp Ala Xaa Val Xaa Val Ile 
625                 630                 635                 640 


Ser Glu Lys Asn Glu Glu Glu Val Leu Val Glu Cys Arg Val Arg Phe 
                645                 650                 655     


Leu Ser Phe Met Gly Val Gly Lys Asp Val His Xaa Phe Ala Phe Ile 
            660                 665                 670         


Met Asp Xaa Gly Asn Gln Arg Phe Glu Cys His Val Phe Trp Cys Glu 
        675                 680                 685             


Pro Asn Ala Gly Asn Val Ser Glu Ala Val Gln Ala Ala Cys Met Leu 
    690                 695                 700                 


Arg Tyr Gln Lys Cys Leu Val Ala Arg Pro Pro Ser Gln Lys Val Arg 
705                 710                 715                 720 


Pro Pro Pro Pro Pro Ala Asp Ser Val Xaa Arg Arg Val Xaa Xaa Asn 
                725                 730                 735     


Val Lys Arg Gly Val Leu Ser Leu Ile Asp Xaa Leu Lys Gln Lys Arg 
            740                 745                 750         


Pro Val Xaa Glu Met Pro 
        755             


<210> 2524
<211> 759
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<400> 2524
Met Ser Glu Val Leu Pro Ala Asp Ser Gly Val Asp Xaa Leu Ala Val 
1               5                   10                  15      


Phe Met Ala Ser Ser Gly Xaa Xaa Asp Val Xaa Asn Arg Asn Ser Pro 
            20                  25                  30          


Ala Xaa Pro Pro Asn Xaa Leu Asn Leu Arg Ser Ser His Asn Glu Leu 
        35                  40                  45              


Leu Asn Ala Glu Ile Lys His Xaa Glu Xaa Lys Asn Ser Xaa Pro Pro 
    50                  55                  60                  


Lys Cys Arg Lys Lys Tyr Ala Leu Xaa Asn Ile Gln Ala Ala Met Gly 
65                  70                  75                  80  


Leu Ser Asp Pro Ala Ala Gln Pro Leu Leu Gly Asn Gly Ser Ala Asn 
                85                  90                  95      


Ile Lys Leu Val Lys Asn Gly Glu Asn Gln Leu Arg Lys Ala Ala Glu 
            100                 105                 110         


Gln Gly Gln Gln Asp Pro Asn Lys Asn Leu Ser Pro Xaa Ala Val Ile 
        115                 120                 125             


Asn Ile Xaa Ser Glu Lys Leu Glu Gly Lys Glu Pro His Pro Gln Asp 
    130                 135                 140                 


Ser Ser Ser Cys Glu Ile Leu Pro Ser Gln Pro Arg Arg Xaa Lys Ser 
145                 150                 155                 160 


Phe Leu Asn Tyr Tyr Ala Asp Leu Glu Xaa Ser Ala Arg Glu Leu Glu 
                165                 170                 175     


Gln Asn Arg Gly Asn His His Gly Xaa Ala Glu Glu Lys Ser Gln Pro 
            180                 185                 190         


Val Gln Gly Gln Ala Ser Xaa Ile Ile Gly Asn Gly Asp Leu Leu Leu 
        195                 200                 205             


Gln Lys Pro Asn Arg Pro Gln Ser Ser Pro Glu Asp Gly Gln Val Ala 
    210                 215                 220                 


Xaa Val Ser Ser Ser Pro Glu Xaa Lys Lys Asp His Pro Lys Xaa Gly 
225                 230                 235                 240 


Ala Lys Xaa Asp Cys Ala Leu His Arg Ile Gln Asn Leu Ala Pro Ser 
                245                 250                 255     


Asp Glu Glu Ser Ser Trp Xaa Xaa Leu Ser Gln Asp Ser Ala Ser Pro 
            260                 265                 270         


Ser Ser Pro Asp Glu Xaa Ala Asp Ile Trp Ser Asp His Ser Phe Gln 
        275                 280                 285             


Xaa Asp Pro Asp Leu Pro Pro Gly Trp Lys Arg Val Ser Asp Ile Ala 
    290                 295                 300                 


Gly Xaa Tyr Tyr Trp His Ile Pro Xaa Gly Xaa Xaa Gln Trp Glu Arg 
305                 310                 315                 320 


Pro Val Ser Ile Pro Ala Asp Leu Gln Gly Ser Arg Lys Gly Ser Leu 
                325                 330                 335     


Ser Ser Val Xaa Pro Ser Pro Xaa Pro Glu Asn Glu Lys Gln Pro Trp 
            340                 345                 350         


Ser Asp Phe Ala Val Leu Asn Gly Gly Lys Ile Asn Ser Asp Ile Trp 
        355                 360                 365             


Lys Asp Leu His Ala Ala Xaa Val Asn Pro Asp Pro Ser Leu Lys Glu 
    370                 375                 380                 


Phe Glu Gly Ala Xaa Leu Arg Tyr Ala Ser Leu Lys Leu Arg Asn Ala 
385                 390                 395                 400 


Pro His Pro Asp Asp Asp Asp Ser Cys Ser Ile Asn Ser Asp Pro Glu 
                405                 410                 415     


Ala Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Ala Glu 
            420                 425                 430         


Glu Asp Leu Ala Pro Gly Lys Ser Ser Val Ala Val Asn Asn Cys Ile 
        435                 440                 445             


Arg Gln Leu Ser Tyr Cys Lys Asn Asp Ile Arg Asp Xaa Val Gly Ile 
    450                 455                 460                 


Trp Gly Glu Gly Lys Asp Met Tyr Leu Ile Leu Glu Asn Asp Met Leu 
465                 470                 475                 480 


Ser Leu Val Asp Pro Met Asp Arg Ser Val Leu His Ser Gln Pro Ile 
                485                 490                 495     


Val Ser Ile Arg Val Trp Gly Val Gly Arg Asp Asn Gly Arg Asp Phe 
            500                 505                 510         


Ala Tyr Val Ala Arg Asp Lys Asp Xaa Arg Ile Leu Lys Cys His Val 
        515                 520                 525             


Phe Arg Cys Asp Xaa Pro Ala Lys Ala Ile Ala Xaa Ser Leu His Glu 
    530                 535                 540                 


Ile Cys Ser Lys Ile Met Ala Glu Arg Lys Asn Ala Lys Ala Leu Ala 
545                 550                 555                 560 


Cys Ser Ser Leu Gln Glu Arg Ala Asn Val Asn Leu Asp Val Pro Leu 
                565                 570                 575     


Gln Val Asp Phe Pro Xaa Pro Lys Xaa Glu Leu Val Gln Lys Phe His 
            580                 585                 590         


Val Gln Tyr Leu Gly Met Leu Pro Val Asp Lys Pro Val Gly Met Asp 
        595                 600                 605             


Ile Leu Asn Ser Ala Ile Glu Asn Leu Met Xaa Ser Ser Asn Lys Glu 
    610                 615                 620                 


Asp Trp Leu Ser Val Asn Met Asn Val Ala Asp Ala Xaa Val Xaa Val 
625                 630                 635                 640 


Ile Ser Glu Lys Asn Glu Glu Glu Val Leu Val Glu Cys Arg Val Arg 
                645                 650                 655     


Phe Leu Ser Phe Met Gly Val Gly Lys Asp Val His Xaa Phe Ala Phe 
            660                 665                 670         


Ile Met Asp Xaa Gly Asn Gln Arg Phe Glu Cys His Val Phe Trp Cys 
        675                 680                 685             


Glu Pro Asn Ala Gly Asn Val Ser Glu Ala Val Gln Ala Ala Cys Met 
    690                 695                 700                 


Leu Arg Tyr Gln Lys Cys Leu Val Ala Arg Pro Pro Ser Gln Lys Val 
705                 710                 715                 720 


Arg Pro Pro Pro Pro Pro Ala Asp Ser Val Xaa Arg Arg Val Xaa Xaa 
                725                 730                 735     


Asn Val Lys Arg Gly Val Leu Ser Leu Ile Asp Xaa Leu Lys Gln Lys 
            740                 745                 750         


Arg Pro Val Xaa Glu Met Pro 
        755                 


<210> 2525
<211> 180
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<400> 2525
Val Leu His Ser Gln Pro Ile Val Ser Ile Arg Val Trp Gly Val Gly 
1               5                   10                  15      


Arg Asp Asn Gly Arg Glu Arg Asp Phe Ala Tyr Val Ala Arg Asp Lys 
            20                  25                  30          


Asp Xaa Arg Ile Leu Lys Cys His Val Phe Arg Cys Asp Xaa Pro Ala 
        35                  40                  45              


Lys Ala Ile Ala Xaa Ser Leu His Glu Ile Cys Ser Lys Ile Met Ala 
    50                  55                  60                  


Glu Arg Lys Asn Ala Lys Ala Leu Ala Cys Ser Ser Leu Gln Glu Arg 
65                  70                  75                  80  


Ala Asn Val Asn Leu Asp Val Pro Leu Gln Val Asp Phe Pro Xaa Pro 
                85                  90                  95      


Lys Xaa Glu Leu Val Gln Lys Phe His Val Gln Tyr Leu Gly Met Leu 
            100                 105                 110         


Pro Val Asp Lys Pro Val Gly Met Asp Ile Leu Asn Ser Ala Ile Glu 
        115                 120                 125             


Asn Leu Met Xaa Ser Ser Asn Lys Glu Asp Trp Leu Ser Val Asn Met 
    130                 135                 140                 


Asn Val Ala Asp Ala Xaa Val Xaa Val Ile Ser Glu Lys Asn Glu Glu 
145                 150                 155                 160 


Glu Val Leu Val Glu Cys Arg Val Arg Phe Leu Ser Phe Met Gly Val 
                165                 170                 175     


Gly Lys Asp Val 
            180 


<210> 2526
<211> 728
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<400> 2526
Xaa Asp Xaa Leu Ala Val Phe Met Ala Ser Ser Gly Xaa Xaa Asp Val 
1               5                   10                  15      


Xaa Asn Arg Asn Ser Pro Ala Xaa Pro Pro Asn Xaa Leu Asn Leu Arg 
            20                  25                  30          


Ser Ser His Asn Glu Leu Leu Asn Ala Glu Ile Lys His Xaa Glu Xaa 
        35                  40                  45              


Lys Asn Ser Xaa Pro Pro Lys Cys Arg Lys Lys Tyr Ala Leu Xaa Asn 
    50                  55                  60                  


Ile Gln Ala Ala Met Gly Leu Ser Asp Pro Ala Ala Gln Pro Leu Leu 
65                  70                  75                  80  


Gly Asn Gly Ser Ala Asn Ile Lys Leu Val Lys Asn Gly Glu Asn Gln 
                85                  90                  95      


Leu Arg Lys Ala Ala Glu Gln Gly Gln Gln Asp Pro Asn Lys Asn Leu 
            100                 105                 110         


Ser Pro Xaa Ala Val Ile Asn Ile Xaa Ser Glu Lys Leu Glu Gly Lys 
        115                 120                 125             


Glu Pro His Pro Gln Asp Ser Ser Ser Cys Glu Ile Leu Pro Ser Gln 
    130                 135                 140                 


Pro Arg Arg Xaa Lys Ser Phe Leu Asn Tyr Tyr Ala Asp Leu Glu Xaa 
145                 150                 155                 160 


Ser Ala Arg Glu Leu Glu Gln Asn Arg Gly Asn His His Gly Xaa Ala 
                165                 170                 175     


Glu Glu Lys Ser Gln Pro Val Gln Gly Gln Ala Ser Xaa Ile Ile Gly 
            180                 185                 190         


Asn Gly Asp Leu Leu Leu Gln Lys Pro Asn Arg Pro Gln Ser Ser Pro 
        195                 200                 205             


Glu Asp Gly Gln Val Ala Xaa Val Ser Ser Ser Pro Glu Xaa Lys Lys 
    210                 215                 220                 


Asp His Pro Lys Xaa Gly Ala Lys Xaa Asp Cys Ala Leu His Arg Ile 
225                 230                 235                 240 


Gln Asn Leu Ala Pro Ser Asp Glu Glu Ser Ser Trp Xaa Xaa Leu Ser 
                245                 250                 255     


Gln Asp Ser Ala Ser Pro Ser Ser Pro Asp Glu Xaa Ala Asp Ile Trp 
            260                 265                 270         


Ser Asp His Ser Phe Gln Xaa Asp Pro Asp Leu Pro Pro Gly Trp Lys 
        275                 280                 285             


Arg Val Ser Asp Ile Ala Gly Xaa Tyr Tyr Trp His Ile Pro Xaa Gly 
    290                 295                 300                 


Xaa Xaa Gln Trp Glu Arg Pro Val Ser Ile Pro Ala Asp Leu Gln Gly 
305                 310                 315                 320 


Ser Arg Lys Gly Ser Leu Ser Ser Val Xaa Pro Ser Pro Xaa Pro Glu 
                325                 330                 335     


Asn Glu Asp Leu His Ala Ala Xaa Val Asn Pro Asp Pro Ser Leu Lys 
            340                 345                 350         


Glu Phe Glu Gly Ala Xaa Leu Arg Tyr Ala Ser Leu Lys Leu Arg Asn 
        355                 360                 365             


Ala Pro His Pro Asp Asp Asp Asp Ser Cys Ser Ile Asn Ser Asp Pro 
    370                 375                 380                 


Glu Ala Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Ala 
385                 390                 395                 400 


Glu Glu Asp Leu Ala Pro Gly Lys Ser Ser Val Ala Val Asn Asn Cys 
                405                 410                 415     


Ile Arg Gln Leu Ser Tyr Cys Lys Asn Asp Ile Arg Asp Xaa Val Gly 
            420                 425                 430         


Ile Trp Gly Glu Gly Lys Asp Met Tyr Leu Ile Leu Glu Asn Asp Met 
        435                 440                 445             


Leu Ser Leu Val Asp Pro Met Asp Arg Ser Val Leu His Ser Gln Pro 
    450                 455                 460                 


Ile Val Ser Ile Arg Val Trp Gly Val Gly Arg Asp Asn Gly Arg Asp 
465                 470                 475                 480 


Phe Ala Tyr Val Ala Arg Asp Lys Asp Xaa Arg Ile Leu Lys Cys His 
                485                 490                 495     


Val Phe Arg Cys Asp Xaa Pro Ala Lys Ala Ile Ala Xaa Ser Leu His 
            500                 505                 510         


Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Lys Asn Ala Lys Ala Leu 
        515                 520                 525             


Ala Cys Ser Ser Leu Gln Glu Arg Ala Asn Val Asn Leu Asp Val Pro 
    530                 535                 540                 


Leu Gln Val Asp Phe Pro Xaa Pro Lys Xaa Glu Leu Val Gln Lys Phe 
545                 550                 555                 560 


His Val Gln Tyr Leu Gly Met Leu Pro Val Asp Lys Pro Val Gly Met 
                565                 570                 575     


Asp Ile Leu Asn Ser Ala Ile Glu Asn Leu Met Xaa Ser Ser Asn Lys 
            580                 585                 590         


Glu Asp Trp Leu Ser Val Asn Met Asn Val Ala Asp Ala Xaa Val Xaa 
        595                 600                 605             


Val Ile Ser Glu Lys Asn Glu Glu Glu Val Leu Val Glu Cys Arg Val 
    610                 615                 620                 


Arg Phe Leu Ser Phe Met Gly Val Gly Lys Asp Val His Xaa Phe Ala 
625                 630                 635                 640 


Phe Ile Met Asp Xaa Gly Asn Gln Arg Phe Glu Cys His Val Phe Trp 
                645                 650                 655     


Cys Glu Pro Asn Ala Gly Asn Val Ser Glu Ala Val Gln Ala Ala Cys 
            660                 665                 670         


Met Leu Arg Tyr Gln Lys Cys Leu Val Ala Arg Pro Pro Ser Gln Lys 
        675                 680                 685             


Val Arg Pro Pro Pro Pro Pro Ala Asp Ser Val Xaa Arg Arg Val Xaa 
    690                 695                 700                 


Xaa Asn Val Lys Arg Gly Val Leu Ser Leu Ile Asp Xaa Leu Lys Gln 
705                 710                 715                 720 


Lys Arg Pro Val Xaa Glu Met Pro 
                725             


<210> 2527
<211> 41
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<400> 2527
Xaa Asp Xaa Pro Ala Lys Ala Ile Ala Xaa Ser Leu His Glu Ile Cys 
1               5                   10                  15      


Ser Lys Val Arg Leu Trp Leu Asn Gly Arg Met Pro Lys Arg Trp Pro 
            20                  25                  30          


Ala Ala Pro Tyr Arg Lys Gly Pro Met 
        35                  40      


<210> 2528
<211> 142
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<400> 2528
Xaa Gly Glu Gly Lys Asp Met Tyr Leu Ile Leu Glu Asn Asp Met Leu 
1               5                   10                  15      


Ser Leu Val Asp Pro Met Asp Arg Ser Val Leu His Ser Gln Pro Ile 
            20                  25                  30          


Val Ser Ile Arg Val Trp Gly Val Gly Arg Asp Asn Gly Arg Glu Arg 
        35                  40                  45              


Asp Phe Ala Tyr Val Ala Arg Asp Lys Asp Xaa Arg Ile Leu Lys Cys 
    50                  55                  60                  


His Val Phe Arg Cys Asp Xaa Pro Ala Lys Ala Ile Ala Xaa Ser Leu 
65                  70                  75                  80  


His Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Lys Asn Ala Lys Ala 
                85                  90                  95      


Leu Ala Cys Ser Ser Leu Gln Glu Arg Ala Asn Val Asn Leu Asp Val 
            100                 105                 110         


Pro Leu Gln Asp Phe Pro Xaa Pro Lys Xaa Glu Leu Val Gln Lys Phe 
        115                 120                 125             


His Val Gln Tyr Leu Gly Met Leu Pro Val Asp Lys Pro Val 
    130                 135                 140         


<210> 2529
<211> 272
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<400> 2529
Leu Ser Phe Asp Glu Glu His Arg His Ala Met Asn Glu Leu Gly Arg 
1               5                   10                  15      


Lys Ala Xaa Arg Gly Ile Ser Ser Gln Glu Leu Gly Gln Gly Leu Ser 
            20                  25                  30          


Gly Gly Leu Gln Ala Ile Ala Glu Leu Leu Gln Val Asp Cys Glu Met 
        35                  40                  45              


Tyr Gly Leu Xaa Asn Asp His Tyr Ser Ile Xaa Leu Arg Arg Tyr Ala 
    50                  55                  60                  


Gly Met Ala Leu Xaa Asn Leu Xaa Phe Gly Asp Val Ala Asn Lys Ala 
65                  70                  75                  80  


Xaa Leu Cys Ser Met Lys Gly Cys Met Arg Ala Leu Val Ala Gln Leu 
                85                  90                  95      


Lys Ser Glu Ser Glu Asp Leu Gln Gln Val Ile Ala Ser Val Leu Arg 
            100                 105                 110         


Asn Leu Ser Trp Arg Ala Asp Val Asn Ser Lys Lys Xaa Leu Arg Glu 
        115                 120                 125             


Val Gly Ser Val Lys Ala Leu Met Glu Cys Ala Leu Glu Val Lys Lys 
    130                 135                 140                 


Glu Ser Xaa Leu Lys Ser Val Leu Ser Ala Leu Trp Asn Leu Ser Ala 
145                 150                 155                 160 


His Cys Xaa Glu Asn Lys Ala Asp Ile Cys Ala Val Asp Gly Ala Leu 
                165                 170                 175     


Ala Phe Leu Val Gly Xaa Leu Xaa Tyr Arg Ser Gln Xaa Asn Xaa Leu 
            180                 185                 190         


Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg Asn Val Ser Ser Leu 
        195                 200                 205             


Ile Ala Xaa Asn Glu Asp His Arg Gln Ile Leu Arg Glu Asn Asn Cys 
    210                 215                 220                 


Leu Gln Xaa Leu Leu Gln His Leu Lys Ser His Ser Leu Xaa Ile Val 
225                 230                 235                 240 


Ser Asn Ala Cys Gly Xaa Leu Trp Asn Leu Ser Ala Arg Asn Pro Lys 
                245                 250                 255     


Asp Gln Glu Ala Leu Trp Asp Met Gly Ala Val Ser Met Leu Lys Asn 
            260                 265                 270         


<210> 2530
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<400> 2530
Met Ala Ala Ala Ser Tyr Asp Gln Leu Leu Lys Gln Val Glu Ala Leu 
1               5                   10                  15      


Lys Met Glu Asn Ser Asn Leu Arg Gln Glu Leu Glu Asp Asn Ser Asn 
            20                  25                  30          


His Leu Xaa Lys Leu Glu Xaa Glu Ala Ser Asn Met Lys Glu Val Leu 
        35                  40                  45              


Lys Gln Leu Gln Gly Ser Ile Glu Asp Glu Ala Met Ala Ser Ser Gly 
    50                  55                  60                  


Gln Ile Asp Leu Leu Glu Arg Leu Lys Glu Leu Asn Leu Asp Ser Ser 
65                  70                  75                  80  


Asn Phe Pro Gly Val Lys Leu Arg Ser Lys Met Ser Leu Arg Ser Tyr 
                85                  90                  95      


Gly Ser Arg Glu Gly Ser Val Ser Ser Arg Ser Gly Glu Cys Ser Pro 
            100                 105                 110         


Val Pro Met Gly Ser Phe 
        115             


<210> 2531
<211> 287
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<400> 2531
Met Ala Ala Ala Ser Tyr Asp Gln Leu Leu Lys Gln Val Glu Ala Leu 
1               5                   10                  15      


Lys Met Glu Asn Ser Asn Leu Arg Gln Glu Leu Glu Asp Asn Ser Asn 
            20                  25                  30          


His Leu Xaa Lys Leu Glu Xaa Glu Ala Ser Asn Met Lys Glu Val Leu 
        35                  40                  45              


Lys Gln Leu Gln Gly Ser Ile Glu Asp Glu Ala Met Ala Ser Ser Gly 
    50                  55                  60                  


Gln Ile Asp Leu Leu Glu Arg Leu Lys Glu Leu Asn Leu Asp Ser Ser 
65                  70                  75                  80  


Asn Phe Pro Gly Val Lys Leu Arg Ser Lys Met Ser Leu Arg Ser Tyr 
                85                  90                  95      


Gly Ser Arg Glu Gly Ser Val Ser Ser Arg Ser Gly Glu Cys Ser Pro 
            100                 105                 110         


Val Pro Met Gly Ser Phe Pro Arg Arg Gly Phe Val Asn Gly Ser Arg 
        115                 120                 125             


Glu Ser Xaa Gly Tyr Leu Glu Glu Leu Glu Lys Glu Arg Ser Leu Leu 
    130                 135                 140                 


Leu Ala Asp Leu Asp Lys Glu Glu Lys Glu Lys Asp Trp Tyr Tyr Ala 
145                 150                 155                 160 


Gln Leu Gln Asn Leu Xaa Lys Arg Ile Asp Ser Leu Pro Leu Xaa Glu 
                165                 170                 175     


Asn Phe Ser Leu Gln Xaa Asp Met Xaa Arg Arg Gln Leu Glu Tyr Glu 
            180                 185                 190         


Ala Arg Gln Ile Arg Val Ala Met Glu Glu Gln Leu Gly Xaa Cys Gln 
        195                 200                 205             


Asp Met Glu Lys Arg Ala Gln Arg Arg Ile Ala Arg Ile Gln Gln Ile 
    210                 215                 220                 


Glu Lys Asp Ile Leu Arg Ile Arg Gln Leu Leu Gln Ser Gln Ala Xaa 
225                 230                 235                 240 


Glu Ala Glu Arg Ser Ser Gln Asn Lys His Glu Xaa Gly Ser His Asp 
                245                 250                 255     


Ala Glu Arg Gln Asn Glu Gly Gln Gly Val Gly Glu Ile Asn Met Ala 
            260                 265                 270         


Xaa Ser Gly Asn Gly Gln Ile Glu Lys Met Arg Met Phe Glu Cys 
        275                 280                 285         


<210> 2532
<211> 1305
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1208)..(1208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1218)..(1218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1248)..(1248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1267)..(1267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<400> 2532
Met Ala Ala Ala Ser Tyr Asp Gln Leu Leu Lys Gln Val Glu Ala Leu 
1               5                   10                  15      


Lys Met Glu Asn Ser Asn Leu Arg Gln Glu Leu Glu Asp Asn Ser Asn 
            20                  25                  30          


His Leu Xaa Lys Leu Glu Xaa Glu Ala Ser Asn Met Lys Glu Val Leu 
        35                  40                  45              


Lys Gln Leu Gln Gly Ser Ile Glu Asp Glu Ala Met Ala Ser Ser Gly 
    50                  55                  60                  


Gln Ile Asp Leu Leu Glu Arg Leu Lys Glu Leu Asn Leu Asp Ser Ser 
65                  70                  75                  80  


Asn Phe Pro Gly Val Lys Leu Arg Ser Lys Met Ser Leu Arg Ser Tyr 
                85                  90                  95      


Gly Ser Arg Glu Gly Ser Val Ser Ser Arg Ser Gly Glu Cys Ser Pro 
            100                 105                 110         


Val Pro Met Gly Ser Phe Pro Arg Arg Gly Phe Val Asn Gly Ser Arg 
        115                 120                 125             


Glu Ser Xaa Gly Tyr Leu Glu Glu Leu Glu Lys Glu Arg Ser Leu Leu 
    130                 135                 140                 


Leu Ala Asp Leu Asp Lys Glu Glu Lys Glu Lys Asp Trp Tyr Tyr Ala 
145                 150                 155                 160 


Gln Leu Gln Asn Leu Xaa Lys Arg Ile Asp Ser Leu Pro Leu Xaa Glu 
                165                 170                 175     


Asn Phe Ser Leu Gln Xaa Asp Met Xaa Arg Arg Gln Leu Glu Tyr Glu 
            180                 185                 190         


Ala Arg Gln Ile Arg Val Ala Met Glu Glu Gln Leu Gly Xaa Cys Gln 
        195                 200                 205             


Asp Met Glu Lys Arg Ala Gln Arg Arg Ile Ala Arg Ile Gln Gln Ile 
    210                 215                 220                 


Glu Lys Asp Ile Leu Arg Ile Arg Gln Leu Leu Gln Ser Gln Ala Xaa 
225                 230                 235                 240 


Glu Ala Glu Arg Ser Ser Gln Asn Lys His Glu Xaa Gly Ser His Asp 
                245                 250                 255     


Ala Glu Arg Gln Asn Glu Gly Gln Gly Val Gly Glu Ile Asn Met Ala 
            260                 265                 270         


Xaa Ser Gly Asn Gly Gln Gly Ser Xaa Xaa Arg Met Asp His Glu Xaa 
        275                 280                 285             


Ala Ser Val Leu Ser Ser Ser Ser Xaa His Ser Ala Pro Arg Arg Leu 
    290                 295                 300                 


Xaa Ser His Leu Gly Xaa Lys Val Glu Met Val Tyr Ser Leu Leu Ser 
305                 310                 315                 320 


Met Leu Gly Xaa His Asp Lys Asp Asp Met Ser Arg Xaa Leu Leu Ala 
                325                 330                 335     


Met Ser Ser Ser Gln Asp Ser Cys Ile Ser Met Arg Gln Ser Gly Cys 
            340                 345                 350         


Leu Pro Leu Leu Ile Gln Leu Leu His Gly Asn Asp Lys Asp Ser Val 
        355                 360                 365             


Leu Leu Gly Asn Ser Arg Gly Ser Lys Glu Ala Arg Ala Arg Ala Ser 
    370                 375                 380                 


Ala Ala Leu His Asn Ile Ile His Ser Gln Pro Asp Asp Lys Arg Gly 
385                 390                 395                 400 


Arg Arg Glu Ile Arg Val Leu His Leu Leu Glu Gln Ile Arg Ala Tyr 
                405                 410                 415     


Cys Glu Xaa Cys Trp Glu Trp Gln Glu Ala His Glu Pro Gly Met Asp 
            420                 425                 430         


Gln Asp Lys Asn Pro Met Pro Ala Pro Val Glu His Gln Ile Cys Pro 
        435                 440                 445             


Ala Val Cys Val Leu Met Lys Leu Ser Phe Asp Glu Glu His Arg His 
    450                 455                 460                 


Ala Met Asn Glu Leu Gly Gly Leu Gln Ala Ile Ala Glu Leu Leu Gln 
465                 470                 475                 480 


Val Asp Cys Glu Met Tyr Gly Leu Xaa Asn Asp His Tyr Ser Ile Xaa 
                485                 490                 495     


Leu Arg Arg Tyr Ala Gly Met Ala Leu Xaa Asn Leu Xaa Phe Gly Asp 
            500                 505                 510         


Val Ala Asn Lys Ala Xaa Leu Cys Ser Met Lys Gly Cys Met Arg Ala 
        515                 520                 525             


Leu Val Ala Gln Leu Lys Ser Glu Ser Glu Asp Leu Gln Gln Val Ile 
    530                 535                 540                 


Ala Ser Val Leu Arg Asn Leu Ser Trp Arg Ala Asp Val Asn Ser Lys 
545                 550                 555                 560 


Lys Xaa Leu Arg Glu Val Gly Ser Val Lys Ala Leu Met Glu Cys Ala 
                565                 570                 575     


Leu Glu Val Lys Lys Glu Ser Xaa Leu Lys Ser Val Leu Ser Ala Leu 
            580                 585                 590         


Trp Asn Leu Ser Ala His Cys Xaa Glu Asn Lys Ala Asp Ile Cys Ala 
        595                 600                 605             


Val Asp Gly Ala Leu Ala Phe Leu Val Gly Xaa Leu Xaa Tyr Arg Ser 
    610                 615                 620                 


Gln Xaa Asn Xaa Leu Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg 
625                 630                 635                 640 


Asn Val Ser Ser Leu Ile Ala Xaa Asn Glu Asp His Arg Gln Ile Leu 
                645                 650                 655     


Arg Glu Asn Asn Cys Leu Gln Xaa Leu Leu Gln His Leu Lys Ser His 
            660                 665                 670         


Ser Leu Xaa Ile Val Ser Asn Ala Cys Gly Xaa Leu Trp Asn Leu Ser 
        675                 680                 685             


Ala Arg Asn Pro Lys Asp Gln Glu Ala Leu Trp Asp Met Gly Ala Val 
    690                 695                 700                 


Ser Met Leu Lys Asn Leu Ile His Ser Lys His Lys Met Ile Ala Met 
705                 710                 715                 720 


Gly Ser Ala Ala Ala Leu Arg Asn Leu Met Ala Asn Arg Pro Ala Lys 
                725                 730                 735     


Tyr Lys Asp Ala Asn Ile Met Ser Pro Gly Ser Ser Leu Pro Ser Leu 
            740                 745                 750         


His Val Arg Lys Gln Lys Ala Leu Glu Ala Glu Leu Asp Ala Gln His 
        755                 760                 765             


Leu Ser Glu Xaa Phe Asp Asn Ile Asp Asn Leu Ser Pro Lys Ala Ser 
    770                 775                 780                 


His Arg Ser Lys Gln Arg His Lys Gln Ser Leu Tyr Gly Asp Tyr Val 
785                 790                 795                 800 


Phe Asp Xaa Asn Arg His Asp Asp Asn Arg Ser Asp Asn Phe Asn Xaa 
                805                 810                 815     


Gly Asn Met Xaa Val Leu Ser Pro Tyr Leu Asn Xaa Xaa Val Leu Pro 
            820                 825                 830         


Ser Ser Ser Ser Ser Arg Gly Ser Leu Asp Ser Ser Arg Ser Glu Lys 
        835                 840                 845             


Asp Arg Ser Leu Glu Arg Glu Arg Gly Ile Gly Leu Gly Asn Tyr His 
    850                 855                 860                 


Pro Ala Xaa Glu Asn Pro Gly Xaa Ser Ser Lys Arg Gly Leu Gln Ile 
865                 870                 875                 880 


Ser Xaa Xaa Ala Ala Gln Ile Ala Lys Val Met Glu Glu Val Ser Ala 
                885                 890                 895     


Ile His Xaa Ser Gln Glu Asp Arg Ser Ser Gly Ser Xaa Xaa Glu Leu 
            900                 905                 910         


His Cys Val Xaa Asp Glu Arg Asn Ala Leu Arg Arg Ser Ser Ala Ala 
        915                 920                 925             


His Xaa His Ser Asn Xaa Tyr Asn Phe Xaa Lys Ser Glu Asn Ser Asn 
    930                 935                 940                 


Arg Xaa Cys Ser Met Pro Tyr Ala Lys Leu Glu Tyr Lys Arg Ser Ser 
945                 950                 955                 960 


Asn Asp Ser Leu Asn Ser Val Ser Ser Ser Asp Gly Tyr Gly Lys Arg 
                965                 970                 975     


Gly Gln Met Lys Pro Ser Ile Glu Ser Tyr Ser Glu Asp Asp Glu Ser 
            980                 985                 990         


Lys Phe Cys Ser Tyr Gly Gln Tyr  Pro Ala Asp Leu Ala  His Lys Ile 
        995                 1000                 1005             


His Ser  Ala Asn His Met Asp  Asp Asn Asp Gly Glu  Leu Asp Xaa 
    1010                 1015                 1020             


Pro Ile  Asn Tyr Ser Leu Lys  Tyr Ser Asp Glu Gln  Leu Asn Ser 
    1025                 1030                 1035             


Gly Arg  Gln Ser Pro Ser Gln  Asn Glu Arg Trp Ala  Arg Pro Lys 
    1040                 1045                 1050             


His Ile  Ile Glu Asp Glu Ile  Lys Gln Ser Glu Gln  Arg Gln Ser 
    1055                 1060                 1065             


Arg Asn  Gln Ser Xaa Xaa Tyr  Pro Val Tyr Xaa Glu  Ser Xaa Asp 
    1070                 1075                 1080             


Asp Lys  His Leu Lys Phe Gln  Pro His Phe Gly Gln  Gln Glu Cys 
    1085                 1090                 1095             


Val Ser  Pro Tyr Arg Ser Arg  Gly Ala Asn Gly Ser  Glu Xaa Asn 
    1100                 1105                 1110             


Arg Val  Gly Ser Asn His Gly  Ile Asn Gln Asn Val  Ser Gln Ser 
    1115                 1120                 1125             


Leu Cys  Gln Glu Asp Asp Tyr  Glu Asp Asp Lys Pro  Xaa Asn Tyr 
    1130                 1135                 1140             


Ser Glu  Arg Tyr Ser Glu Glu  Glu Gln His Glu Glu  Glu Glu Arg 
    1145                 1150                 1155             


Pro Xaa  Asn Tyr Ser Ile Lys  Tyr Asn Glu Glu Lys  Arg His Val 
    1160                 1165                 1170             


Asp Gln  Pro Ile Asp Tyr Ser  Leu Lys Tyr Ala Xaa  Asp Ile Pro 
    1175                 1180                 1185             


Ser Ser  Gln Lys Gln Ser Phe  Ser Phe Ser Lys Ser  Ser Ser Gly 
    1190                 1195                 1200             


Gln Ser  Ser Lys Xaa Glu His  Met Ser Ser Ser Ser  Glu Asn Xaa 
    1205                 1210                 1215             


Ser Xaa  Pro Ser Ser Asn Ala  Lys Arg Gln Asn Gln  Leu His Pro 
    1220                 1225                 1230             


Ser Ser  Ala Gln Ser Arg Ser  Gly Gln Pro Gln Lys  Ala Ala Xaa 
    1235                 1240                 1245             


Cys Lys  Val Ser Ser Ile Asn  Gln Glu Xaa Ile Gln  Xaa Tyr Cys 
    1250                 1255                 1260             


Val Glu  Asp Xaa Pro Ile Cys  Phe Ser Arg Cys Ser  Ser Leu Ser 
    1265                 1270                 1275             


Ser Leu  Ser Ser Ala Glu Asp  Glu Ile Gly Cys Asn  Gln Xaa Xaa 
    1280                 1285                 1290             


Gln Glu  Ala Asp Ser Ala Asn  Xaa Leu Gln Ile Ala  
    1295                 1300                 1305 


<210> 2533
<211> 2843
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1208)..(1208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1218)..(1218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1248)..(1248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1267)..(1267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1313)..(1313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1368)..(1368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1380)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1388)..(1388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1430)..(1430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1438)..(1438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1448)..(1448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1459)..(1459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1487)..(1487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1493)..(1493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1496)..(1496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1537)..(1537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1556)..(1556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1585)..(1585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1597)..(1597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1647)..(1647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1653)..(1653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1655)..(1655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1661)..(1661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1689)..(1689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1692)..(1692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1697)..(1697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1705)..(1705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1709)..(1709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1783)..(1783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1847)..(1847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1852)..(1852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1895)..(1895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1898)..(1898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1901)..(1901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1910)..(1910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1932)..(1932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1947)..(1947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1959)..(1959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1990)..(1990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2017)..(2017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2077)..(2077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2151)..(2151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2160)..(2160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2175)..(2175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2178)..(2178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2200)..(2200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2229)..(2229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2243)..(2243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2255)..(2255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2266)..(2266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2268)..(2269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2289)..(2289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2308)..(2308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2348)..(2348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2353)..(2353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2356)..(2356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2367)..(2367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2379)..(2379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2382)..(2382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2422)..(2422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2442)..(2442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2451)..(2451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2475)..(2475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2481)..(2481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2495)..(2495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2514)..(2514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2546)..(2546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2563)..(2563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2567)..(2567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2598)..(2598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2611)..(2611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2623)..(2623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2626)..(2626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2629)..(2629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2635)..(2635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2642)..(2642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2654)..(2654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2676)..(2676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2679)..(2679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2715)..(2715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2736)..(2736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2751)..(2751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2760)..(2760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2776)..(2776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2782)..(2782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2798)..(2798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2807)..(2807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2813)..(2813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2820)..(2820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2823)..(2823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2828)..(2828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2841)..(2841)
<223> Selenocysteine

<400> 2533
Met Ala Ala Ala Ser Tyr Asp Gln Leu Leu Lys Gln Val Glu Ala Leu 
1               5                   10                  15      


Lys Met Glu Asn Ser Asn Leu Arg Gln Glu Leu Glu Asp Asn Ser Asn 
            20                  25                  30          


His Leu Xaa Lys Leu Glu Xaa Glu Ala Ser Asn Met Lys Glu Val Leu 
        35                  40                  45              


Lys Gln Leu Gln Gly Ser Ile Glu Asp Glu Ala Met Ala Ser Ser Gly 
    50                  55                  60                  


Gln Ile Asp Leu Leu Glu Arg Leu Lys Glu Leu Asn Leu Asp Ser Ser 
65                  70                  75                  80  


Asn Phe Pro Gly Val Lys Leu Arg Ser Lys Met Ser Leu Arg Ser Tyr 
                85                  90                  95      


Gly Ser Arg Glu Gly Ser Val Ser Ser Arg Ser Gly Glu Cys Ser Pro 
            100                 105                 110         


Val Pro Met Gly Ser Phe Pro Arg Arg Gly Phe Val Asn Gly Ser Arg 
        115                 120                 125             


Glu Ser Xaa Gly Tyr Leu Glu Glu Leu Glu Lys Glu Arg Ser Leu Leu 
    130                 135                 140                 


Leu Ala Asp Leu Asp Lys Glu Glu Lys Glu Lys Asp Trp Tyr Tyr Ala 
145                 150                 155                 160 


Gln Leu Gln Asn Leu Xaa Lys Arg Ile Asp Ser Leu Pro Leu Xaa Glu 
                165                 170                 175     


Asn Phe Ser Leu Gln Xaa Asp Met Xaa Arg Arg Gln Leu Glu Tyr Glu 
            180                 185                 190         


Ala Arg Gln Ile Arg Val Ala Met Glu Glu Gln Leu Gly Xaa Cys Gln 
        195                 200                 205             


Asp Met Glu Lys Arg Ala Gln Arg Arg Ile Ala Arg Ile Gln Gln Ile 
    210                 215                 220                 


Glu Lys Asp Ile Leu Arg Ile Arg Gln Leu Leu Gln Ser Gln Ala Xaa 
225                 230                 235                 240 


Glu Ala Glu Arg Ser Ser Gln Asn Lys His Glu Xaa Gly Ser His Asp 
                245                 250                 255     


Ala Glu Arg Gln Asn Glu Gly Gln Gly Val Gly Glu Ile Asn Met Ala 
            260                 265                 270         


Xaa Ser Gly Asn Gly Gln Gly Ser Xaa Xaa Arg Met Asp His Glu Xaa 
        275                 280                 285             


Ala Ser Val Leu Ser Ser Ser Ser Xaa His Ser Ala Pro Arg Arg Leu 
    290                 295                 300                 


Xaa Ser His Leu Gly Xaa Lys Val Glu Met Val Tyr Ser Leu Leu Ser 
305                 310                 315                 320 


Met Leu Gly Xaa His Asp Lys Asp Asp Met Ser Arg Xaa Leu Leu Ala 
                325                 330                 335     


Met Ser Ser Ser Gln Asp Ser Cys Ile Ser Met Arg Gln Ser Gly Cys 
            340                 345                 350         


Leu Pro Leu Leu Ile Gln Leu Leu His Gly Asn Asp Lys Asp Ser Val 
        355                 360                 365             


Leu Leu Gly Asn Ser Arg Gly Ser Lys Glu Ala Arg Ala Arg Ala Ser 
    370                 375                 380                 


Ala Ala Leu His Asn Ile Ile His Ser Gln Pro Asp Asp Lys Arg Gly 
385                 390                 395                 400 


Arg Arg Glu Ile Arg Val Leu His Leu Leu Glu Gln Ile Arg Ala Tyr 
                405                 410                 415     


Cys Glu Xaa Cys Trp Glu Trp Gln Glu Ala His Glu Pro Gly Met Asp 
            420                 425                 430         


Gln Asp Lys Asn Pro Met Pro Ala Pro Val Glu His Gln Ile Cys Pro 
        435                 440                 445             


Ala Val Cys Val Leu Met Lys Leu Ser Phe Asp Glu Glu His Arg His 
    450                 455                 460                 


Ala Met Asn Glu Leu Gly Gly Leu Gln Ala Ile Ala Glu Leu Leu Gln 
465                 470                 475                 480 


Val Asp Cys Glu Met Tyr Gly Leu Xaa Asn Asp His Tyr Ser Ile Xaa 
                485                 490                 495     


Leu Arg Arg Tyr Ala Gly Met Ala Leu Xaa Asn Leu Xaa Phe Gly Asp 
            500                 505                 510         


Val Ala Asn Lys Ala Xaa Leu Cys Ser Met Lys Gly Cys Met Arg Ala 
        515                 520                 525             


Leu Val Ala Gln Leu Lys Ser Glu Ser Glu Asp Leu Gln Gln Val Ile 
    530                 535                 540                 


Ala Ser Val Leu Arg Asn Leu Ser Trp Arg Ala Asp Val Asn Ser Lys 
545                 550                 555                 560 


Lys Xaa Leu Arg Glu Val Gly Ser Val Lys Ala Leu Met Glu Cys Ala 
                565                 570                 575     


Leu Glu Val Lys Lys Glu Ser Xaa Leu Lys Ser Val Leu Ser Ala Leu 
            580                 585                 590         


Trp Asn Leu Ser Ala His Cys Xaa Glu Asn Lys Ala Asp Ile Cys Ala 
        595                 600                 605             


Val Asp Gly Ala Leu Ala Phe Leu Val Gly Xaa Leu Xaa Tyr Arg Ser 
    610                 615                 620                 


Gln Xaa Asn Xaa Leu Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg 
625                 630                 635                 640 


Asn Val Ser Ser Leu Ile Ala Xaa Asn Glu Asp His Arg Gln Ile Leu 
                645                 650                 655     


Arg Glu Asn Asn Cys Leu Gln Xaa Leu Leu Gln His Leu Lys Ser His 
            660                 665                 670         


Ser Leu Xaa Ile Val Ser Asn Ala Cys Gly Xaa Leu Trp Asn Leu Ser 
        675                 680                 685             


Ala Arg Asn Pro Lys Asp Gln Glu Ala Leu Trp Asp Met Gly Ala Val 
    690                 695                 700                 


Ser Met Leu Lys Asn Leu Ile His Ser Lys His Lys Met Ile Ala Met 
705                 710                 715                 720 


Gly Ser Ala Ala Ala Leu Arg Asn Leu Met Ala Asn Arg Pro Ala Lys 
                725                 730                 735     


Tyr Lys Asp Ala Asn Ile Met Ser Pro Gly Ser Ser Leu Pro Ser Leu 
            740                 745                 750         


His Val Arg Lys Gln Lys Ala Leu Glu Ala Glu Leu Asp Ala Gln His 
        755                 760                 765             


Leu Ser Glu Xaa Phe Asp Asn Ile Asp Asn Leu Ser Pro Lys Ala Ser 
    770                 775                 780                 


His Arg Ser Lys Gln Arg His Lys Gln Ser Leu Tyr Gly Asp Tyr Val 
785                 790                 795                 800 


Phe Asp Xaa Asn Arg His Asp Asp Asn Arg Ser Asp Asn Phe Asn Xaa 
                805                 810                 815     


Gly Asn Met Xaa Val Leu Ser Pro Tyr Leu Asn Xaa Xaa Val Leu Pro 
            820                 825                 830         


Ser Ser Ser Ser Ser Arg Gly Ser Leu Asp Ser Ser Arg Ser Glu Lys 
        835                 840                 845             


Asp Arg Ser Leu Glu Arg Glu Arg Gly Ile Gly Leu Gly Asn Tyr His 
    850                 855                 860                 


Pro Ala Xaa Glu Asn Pro Gly Xaa Ser Ser Lys Arg Gly Leu Gln Ile 
865                 870                 875                 880 


Ser Xaa Xaa Ala Ala Gln Ile Ala Lys Val Met Glu Glu Val Ser Ala 
                885                 890                 895     


Ile His Xaa Ser Gln Glu Asp Arg Ser Ser Gly Ser Xaa Xaa Glu Leu 
            900                 905                 910         


His Cys Val Xaa Asp Glu Arg Asn Ala Leu Arg Arg Ser Ser Ala Ala 
        915                 920                 925             


His Xaa His Ser Asn Xaa Tyr Asn Phe Xaa Lys Ser Glu Asn Ser Asn 
    930                 935                 940                 


Arg Xaa Cys Ser Met Pro Tyr Ala Lys Leu Glu Tyr Lys Arg Ser Ser 
945                 950                 955                 960 


Asn Asp Ser Leu Asn Ser Val Ser Ser Ser Asp Gly Tyr Gly Lys Arg 
                965                 970                 975     


Gly Gln Met Lys Pro Ser Ile Glu Ser Tyr Ser Glu Asp Asp Glu Ser 
            980                 985                 990         


Lys Phe Cys Ser Tyr Gly Gln Tyr  Pro Ala Asp Leu Ala  His Lys Ile 
        995                 1000                 1005             


His Ser  Ala Asn His Met Asp  Asp Asn Asp Gly Glu  Leu Asp Xaa 
    1010                 1015                 1020             


Pro Ile  Asn Tyr Ser Leu Lys  Tyr Ser Asp Glu Gln  Leu Asn Ser 
    1025                 1030                 1035             


Gly Arg  Gln Ser Pro Ser Gln  Asn Glu Arg Trp Ala  Arg Pro Lys 
    1040                 1045                 1050             


His Ile  Ile Glu Asp Glu Ile  Lys Gln Ser Glu Gln  Arg Gln Ser 
    1055                 1060                 1065             


Arg Asn  Gln Ser Xaa Xaa Tyr  Pro Val Tyr Xaa Glu  Ser Xaa Asp 
    1070                 1075                 1080             


Asp Lys  His Leu Lys Phe Gln  Pro His Phe Gly Gln  Gln Glu Cys 
    1085                 1090                 1095             


Val Ser  Pro Tyr Arg Ser Arg  Gly Ala Asn Gly Ser  Glu Xaa Asn 
    1100                 1105                 1110             


Arg Val  Gly Ser Asn His Gly  Ile Asn Gln Asn Val  Ser Gln Ser 
    1115                 1120                 1125             


Leu Cys  Gln Glu Asp Asp Tyr  Glu Asp Asp Lys Pro  Xaa Asn Tyr 
    1130                 1135                 1140             


Ser Glu  Arg Tyr Ser Glu Glu  Glu Gln His Glu Glu  Glu Glu Arg 
    1145                 1150                 1155             


Pro Xaa  Asn Tyr Ser Ile Lys  Tyr Asn Glu Glu Lys  Arg His Val 
    1160                 1165                 1170             


Asp Gln  Pro Ile Asp Tyr Ser  Leu Lys Tyr Ala Xaa  Asp Ile Pro 
    1175                 1180                 1185             


Ser Ser  Gln Lys Gln Ser Phe  Ser Phe Ser Lys Ser  Ser Ser Gly 
    1190                 1195                 1200             


Gln Ser  Ser Lys Xaa Glu His  Met Ser Ser Ser Ser  Glu Asn Xaa 
    1205                 1210                 1215             


Ser Xaa  Pro Ser Ser Asn Ala  Lys Arg Gln Asn Gln  Leu His Pro 
    1220                 1225                 1230             


Ser Ser  Ala Gln Ser Arg Ser  Gly Gln Pro Gln Lys  Ala Ala Xaa 
    1235                 1240                 1245             


Cys Lys  Val Ser Ser Ile Asn  Gln Glu Xaa Ile Gln  Xaa Tyr Cys 
    1250                 1255                 1260             


Val Glu  Asp Xaa Pro Ile Cys  Phe Ser Arg Cys Ser  Ser Leu Ser 
    1265                 1270                 1275             


Ser Leu  Ser Ser Ala Glu Asp  Glu Ile Gly Cys Asn  Gln Xaa Xaa 
    1280                 1285                 1290             


Gln Glu  Ala Asp Ser Ala Asn  Xaa Leu Gln Ile Ala  Glu Ile Lys 
    1295                 1300                 1305             


Glu Lys  Ile Gly Xaa Arg Ser  Ala Glu Asp Pro Val  Ser Glu Val 
    1310                 1315                 1320             


Pro Ala  Val Ser Gln His Pro  Arg Xaa Lys Ser Ser  Arg Leu Gln 
    1325                 1330                 1335             


Gly Ser  Ser Leu Ser Ser Glu  Ser Ala Arg His Lys  Ala Val Glu 
    1340                 1345                 1350             


Phe Ser  Ser Gly Ala Lys Ser  Pro Ser Lys Ser Gly  Ala Gln Xaa 
    1355                 1360                 1365             


Pro Lys  Ser Pro Pro Glu His  Tyr Val Gln Glu Xaa  Pro Leu Met 
    1370                 1375                 1380             


Phe Ser  Arg Cys Xaa Ser Val  Ser Ser Leu Asp Ser  Phe Glu Ser 
    1385                 1390                 1395             


Arg Ser  Ile Ala Ser Ser Val  Gln Ser Glu Pro Cys  Ser Gly Met 
    1400                 1405                 1410             


Val Ser  Gly Ile Ile Ser Pro  Ser Asp Leu Pro Asp  Ser Pro Gly 
    1415                 1420                 1425             


Gln Xaa  Met Pro Pro Ser Arg  Ser Lys Xaa Pro Pro  Pro Pro Pro 
    1430                 1435                 1440             


Gln Xaa  Ala Gln Xaa Lys Arg  Glu Val Pro Lys Asn  Lys Ala Pro 
    1445                 1450                 1455             


Xaa Ala  Glu Lys Arg Glu Ser  Gly Pro Lys Gln Ala  Ala Val Asn 
    1460                 1465                 1470             


Ala Ala  Val Gln Arg Val Gln  Val Leu Pro Asp Ala  Asp Xaa Leu 
    1475                 1480                 1485             


Leu His  Phe Ala Xaa Glu Ser  Xaa Pro Asp Gly Phe  Ser Cys Ser 
    1490                 1495                 1500             


Ser Ser  Leu Ser Ala Leu Ser  Leu Asp Glu Pro Phe  Ile Gln Lys 
    1505                 1510                 1515             


Asp Val  Glu Leu Arg Ile Met  Pro Pro Val Gln Glu  Asn Asp Asn 
    1520                 1525                 1530             


Gly Asn  Glu Xaa Glu Ser Glu  Gln Pro Lys Glu Ser  Asn Glu Asn 
    1535                 1540                 1545             


Gln Glu  Lys Glu Ala Glu Lys  Xaa Ile Asp Ser Glu  Lys Asp Leu 
    1550                 1555                 1560             


Leu Asp  Asp Ser Asp Asp Asp  Asp Ile Glu Ile Leu  Glu Glu Cys 
    1565                 1570                 1575             


Ile Ile  Ser Ala Met Pro Xaa  Lys Ser Ser Arg Lys  Ala Lys Lys 
    1580                 1585                 1590             


Pro Ala  Gln Xaa Ala Ser Lys  Leu Pro Pro Pro Val  Ala Arg Lys 
    1595                 1600                 1605             


Pro Ser  Gln Leu Pro Val Tyr  Lys Leu Leu Pro Ser  Gln Asn Arg 
    1610                 1615                 1620             


Leu Gln  Pro Gln Lys His Val  Ser Phe Xaa Pro Gly  Asp Asp Met 
    1625                 1630                 1635             


Pro Arg  Val Tyr Cys Val Glu  Gly Xaa Pro Ile Asn  Phe Ser Xaa 
    1640                 1645                 1650             


Ala Xaa  Ser Leu Ser Asp Leu  Xaa Ile Glu Ser Pro  Pro Asn Glu 
    1655                 1660                 1665             


Leu Ala  Ala Gly Glu Gly Val  Arg Gly Gly Ala Gln  Ser Gly Glu 
    1670                 1675                 1680             


Phe Glu  Lys Arg Asp Xaa Ile  Pro Xaa Glu Gly Arg  Ser Xaa Asp 
    1685                 1690                 1695             


Glu Ala  Gln Gly Gly Lys Xaa  Ser Ser Val Xaa Ile  Pro Glu Leu 
    1700                 1705                 1710             


Asp Asp  Asn Lys Ala Glu Glu  Gly Asp Ile Leu Ala  Glu Cys Ile 
    1715                 1720                 1725             


Asn Ser  Ala Met Pro Lys Gly  Lys Ser His Lys Pro  Phe Arg Val 
    1730                 1735                 1740             


Lys Lys  Ile Met Asp Gln Val  Gln Gln Ala Ser Ala  Ser Ser Ser 
    1745                 1750                 1755             


Ala Pro  Asn Lys Asn Gln Leu  Asp Gly Lys Lys Lys  Lys Pro Xaa 
    1760                 1765                 1770             


Ser Pro  Val Lys Pro Ile Pro  Gln Asn Xaa Glu Tyr  Arg Xaa Arg 
    1775                 1780                 1785             


Val Arg  Lys Asn Ala Asp Ser  Lys Asn Asn Leu Asn  Ala Glu Arg 
    1790                 1795                 1800             


Val Phe  Ser Asp Asn Lys Asp  Ser Lys Lys Gln Asn  Leu Lys Asn 
    1805                 1810                 1815             


Asn Ser  Lys Val Phe Asn Asp  Lys Leu Pro Asn Asn  Glu Asp Arg 
    1820                 1825                 1830             


Val Arg  Gly Ser Phe Ala Phe  Asp Ser Pro His His  Tyr Xaa Pro 
    1835                 1840                 1845             


Ile Glu  Gly Xaa Pro Tyr Cys  Phe Ser Arg Asn Asp  Ser Leu Ser 
    1850                 1855                 1860             


Ser Leu  Asp Phe Asp Asp Asp  Asp Val Asp Leu Ser  Arg Glu Lys 
    1865                 1870                 1875             


Ala Glu  Leu Arg Lys Ala Lys  Glu Asn Lys Glu Ser  Glu Ala Lys 
    1880                 1885                 1890             


Val Xaa  Ser His Xaa Glu Leu  Xaa Ser Asn Gln Gln  Ser Ala Asn 
    1895                 1900                 1905             


Lys Xaa  Gln Ala Ile Ala Lys  Gln Pro Ile Asn Arg  Gly Gln Pro 
    1910                 1915                 1920             


Lys Pro  Ile Leu Gln Lys Gln  Ser Xaa Phe Pro Gln  Ser Ser Lys 
    1925                 1930                 1935             


Asp Ile  Pro Asp Arg Gly Ala  Ala Xaa Asp Glu Lys  Leu Gln Asn 
    1940                 1945                 1950             


Phe Ala  Ile Glu Asn Xaa Pro  Val Cys Phe Ser His  Asn Ser Ser 
    1955                 1960                 1965             


Leu Ser  Ser Leu Ser Asp Ile  Asp Gln Glu Asn Asn  Asn Lys Glu 
    1970                 1975                 1980             


Asn Glu  Pro Ile Lys Glu Xaa  Glu Pro Pro Asp Ser  Gln Gly Glu 
    1985                 1990                 1995             


Pro Ser  Lys Pro Gln Ala Ser  Gly Tyr Ala Pro Lys  Ser Phe His 
    2000                 2005                 2010             


Val Glu  Asp Xaa Pro Val Cys  Phe Ser Arg Asn Ser  Ser Leu Ser 
    2015                 2020                 2025             


Ser Leu  Ser Ile Asp Ser Glu  Asp Asp Leu Leu Gln  Glu Cys Ile 
    2030                 2035                 2040             


Ser Ser  Ala Met Pro Lys Lys  Lys Lys Pro Ser Arg  Leu Lys Gly 
    2045                 2050                 2055             


Asp Asn  Glu Lys His Ser Pro  Arg Asn Met Gly Gly  Ile Leu Gly 
    2060                 2065                 2070             


Glu Asp  Leu Xaa Leu Asp Leu  Lys Asp Ile Gln Arg  Pro Asp Ser 
    2075                 2080                 2085             


Glu His  Gly Leu Ser Pro Asp  Ser Glu Asn Phe Asp  Trp Lys Ala 
    2090                 2095                 2100             


Ile Gln  Glu Gly Ala Asn Ser  Ile Val Ser Ser Leu  His Gln Ala 
    2105                 2110                 2115             


Ala Ala  Ala Ala Cys Leu Ser  Arg Gln Ala Ser Ser  Asp Ser Asp 
    2120                 2125                 2130             


Ser Ile  Leu Ser Leu Lys Ser  Gly Ile Ser Leu Gly  Ser Pro Phe 
    2135                 2140                 2145             


His Leu  Xaa Pro Asp Gln Glu  Glu Lys Pro Phe Xaa  Ser Asn Lys 
    2150                 2155                 2160             


Gly Pro  Arg Ile Leu Lys Pro  Gly Glu Lys Ser Xaa  Leu Glu Xaa 
    2165                 2170                 2175             


Lys Lys  Ile Glu Ser Glu Ser  Lys Gly Ile Lys Gly  Gly Lys Lys 
    2180                 2185                 2190             


Val Tyr  Lys Ser Leu Ile Xaa  Gly Lys Val Arg Ser  Asn Ser Glu 
    2195                 2200                 2205             


Ile Ser  Gly Gln Met Lys Gln  Pro Leu Gln Ala Asn  Met Pro Ser 
    2210                 2215                 2220             


Ile Ser  Arg Gly Arg Xaa Met  Ile His Ile Pro Gly  Val Arg Asn 
    2225                 2230                 2235             


Ser Ser  Ser Ser Xaa Ser Pro  Val Ser Lys Lys Gly  Pro Pro Leu 
    2240                 2245                 2250             


Lys Xaa  Pro Ala Ser Lys Ser  Pro Ser Glu Gly Gln  Xaa Ala Xaa 
    2255                 2260                 2265             


Xaa Ser  Pro Arg Gly Ala Lys  Pro Ser Val Lys Ser  Glu Leu Ser 
    2270                 2275                 2280             


Pro Val  Ala Arg Gln Xaa Ser  Gln Ile Gly Gly Ser  Ser Lys Ala 
    2285                 2290                 2295             


Pro Ser  Arg Ser Gly Ser Arg  Asp Ser Xaa Pro Ser  Arg Pro Ala 
    2300                 2305                 2310             


Gln Gln  Pro Leu Ser Arg Pro  Ile Gln Ser Pro Gly  Arg Asn Ser 
    2315                 2320                 2325             


Ile Ser  Pro Gly Arg Asn Gly  Ile Ser Pro Pro Asn  Lys Leu Ser 
    2330                 2335                 2340             


Gln Leu  Pro Arg Xaa Ser Ser  Pro Ser Xaa Ala Ser  Xaa Lys Ser 
    2345                 2350                 2355             


Ser Gly  Ser Gly Lys Met Ser  Tyr Xaa Ser Pro Gly  Arg Gln Met 
    2360                 2365                 2370             


Ser Gln  Gln Asn Leu Xaa Lys  Gln Xaa Gly Leu Ser  Lys Asn Ala 
    2375                 2380                 2385             


Ser Ser  Ile Pro Arg Ser Glu  Ser Ala Ser Lys Gly  Leu Asn Gln 
    2390                 2395                 2400             


Met Asn  Asn Gly Asn Gly Ala  Asn Lys Lys Val Glu  Leu Ser Arg 
    2405                 2410                 2415             


Met Ser  Ser Xaa Lys Ser Ser  Gly Ser Glu Ser Asp  Arg Ser Glu 
    2420                 2425                 2430             


Arg Pro  Val Leu Val Arg Gln  Ser Xaa Phe Ile Lys  Glu Ala Pro 
    2435                 2440                 2445             


Ser Pro  Xaa Leu Arg Arg Lys  Leu Glu Glu Ser Ala  Ser Phe Glu 
    2450                 2455                 2460             


Ser Leu  Ser Pro Ser Ser Arg  Pro Ala Ser Pro Xaa  Arg Ser Gln 
    2465                 2470                 2475             


Ala Gln  Xaa Pro Val Leu Ser  Pro Ser Leu Pro Asp  Met Ser Leu 
    2480                 2485                 2490             


Ser Xaa  His Ser Ser Val Gln  Ala Gly Gly Trp Arg  Lys Leu Pro 
    2495                 2500                 2505             


Pro Asn  Leu Ser Pro Xaa Ile  Glu Tyr Asn Asp Gly  Arg Pro Ala 
    2510                 2515                 2520             


Lys Arg  His Asp Ile Ala Arg  Ser His Ser Glu Ser  Pro Ser Arg 
    2525                 2530                 2535             


Leu Pro  Ile Asn Arg Ser Gly  Xaa Trp Lys Arg Glu  His Ser Lys 
    2540                 2545                 2550             


His Ser  Ser Ser Leu Pro Arg  Val Ser Xaa Trp Arg  Arg Xaa Gly 
    2555                 2560                 2565             


Ser Ser  Ser Ser Ile Leu Ser  Ala Ser Ser Glu Ser  Ser Glu Lys 
    2570                 2575                 2580             


Ala Lys  Ser Glu Asp Glu Lys  His Val Asn Ser Ile  Ser Gly Xaa 
    2585                 2590                 2595             


Lys Gln  Ser Lys Glu Asn Gln  Val Ser Ala Lys Gly  Xaa Trp Arg 
    2600                 2605                 2610             


Lys Ile  Lys Glu Asn Glu Phe  Ser Pro Xaa Asn Ser  Xaa Ser Gln 
    2615                 2620                 2625             


Xaa Val  Ser Ser Gly Ala Xaa  Asn Gly Ala Glu Ser  Lys Xaa Leu 
    2630                 2635                 2640             


Ile Tyr  Gln Met Ala Pro Ala  Val Ser Lys Xaa Glu  Asp Val Trp 
    2645                 2650                 2655             


Val Arg  Ile Glu Asp Cys Pro  Ile Asn Asn Pro Arg  Ser Gly Arg 
    2660                 2665                 2670             


Ser Pro  Xaa Gly Asn Xaa Pro  Pro Val Ile Asp Ser  Val Ser Glu 
    2675                 2680                 2685             


Lys Ala  Asn Pro Asn Ile Lys  Asp Ser Lys Asp Asn  Gln Ala Lys 
    2690                 2695                 2700             


Gln Asn  Val Gly Asn Gly Ser  Val Pro Met Arg Xaa  Val Gly Leu 
    2705                 2710                 2715             


Glu Asn  Arg Leu Asn Ser Phe  Ile Gln Val Asp Ala  Pro Asp Gln 
    2720                 2725                 2730             


Lys Gly  Xaa Glu Ile Lys Pro  Gly Gln Asn Asn Pro  Val Pro Val 
    2735                 2740                 2745             


Ser Glu  Xaa Asn Glu Ser Ser  Ile Val Glu Arg Xaa  Pro Phe Ser 
    2750                 2755                 2760             


Ser Ser  Ser Ser Ser Lys His  Ser Ser Pro Ser Gly  Xaa Val Ala 
    2765                 2770                 2775             


Ala Arg  Val Xaa Pro Phe Asn  Tyr Asn Pro Ser Pro  Arg Lys Ser 
    2780                 2785                 2790             


Ser Ala  Asp Ser Xaa Ser Ala  Arg Pro Ser Gln Ile  Pro Xaa Pro 
    2795                 2800                 2805             


Val Asn  Asn Asn Xaa Lys Lys  Arg Asp Ser Lys Xaa  Asp Ser Xaa 
    2810                 2815                 2820             


Glu Ser  Ser Gly Xaa Gln Ser  Pro Lys Arg His Ser  Gly Ser Tyr 
    2825                 2830                 2835             


Leu Val  Xaa Ser Val 
    2840             


<210> 2534
<211> 1135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1123)..(1123)
<223> Selenocysteine

<400> 2534
Met Tyr Ala Ser Leu Gly Ser Gly Pro Val Ala Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Pro Pro Ser Val Leu Gly Ser Trp Ser Xaa Gly Gly Ser Arg Ser 
            20                  25                  30          


Cys Val Arg Gln Glu Xaa Lys Ser Pro Gly Gly Ala Arg Xaa Ser Gly 
        35                  40                  45              


His Trp Ala Ser Val Trp Gln Glu Val Leu Lys Gln Leu Gln Gly Ser 
    50                  55                  60                  


Ile Glu Asp Glu Ala Met Ala Ser Ser Gly Gln Ile Asp Leu Leu Glu 
65                  70                  75                  80  


Arg Leu Lys Glu Leu Asn Leu Asp Ser Ser Asn Phe Pro Gly Val Lys 
                85                  90                  95      


Leu Arg Ser Lys Met Ser Leu Arg Ser Tyr Gly Ser Arg Glu Gly Ser 
            100                 105                 110         


Val Ser Ser Arg Ser Gly Glu Cys Ser Pro Val Pro Met Gly Ser Phe 
        115                 120                 125             


Pro Arg Arg Gly Phe Val Asn Gly Ser Arg Glu Ser Xaa Gly Tyr Leu 
    130                 135                 140                 


Glu Glu Leu Glu Lys Glu Arg Ser Leu Leu Leu Ala Asp Leu Asp Lys 
145                 150                 155                 160 


Glu Glu Lys Glu Lys Asp Trp Tyr Tyr Ala Gln Leu Gln Asn Leu Xaa 
                165                 170                 175     


Lys Arg Ile Asp Ser Leu Pro Leu Xaa Glu Asn Phe Ser Leu Gln Xaa 
            180                 185                 190         


Asp Met Xaa Arg Arg Gln Leu Glu Tyr Glu Ala Arg Gln Ile Arg Val 
        195                 200                 205             


Ala Met Glu Glu Gln Leu Gly Xaa Cys Gln Asp Met Glu Lys Arg Ala 
    210                 215                 220                 


Gln Arg Ser Ser Gln Asn Lys His Glu Xaa Gly Ser His Asp Ala Glu 
225                 230                 235                 240 


Arg Gln Asn Glu Gly Gln Gly Val Gly Glu Ile Asn Met Ala Xaa Ser 
                245                 250                 255     


Gly Asn Gly Gln Gly Ser Xaa Xaa Arg Met Asp His Glu Xaa Ala Ser 
            260                 265                 270         


Val Leu Ser Ser Ser Ser Xaa His Ser Ala Pro Arg Arg Leu Xaa Ser 
        275                 280                 285             


His Leu Gly Xaa Lys Val Glu Met Val Tyr Ser Leu Leu Ser Met Leu 
    290                 295                 300                 


Gly Xaa His Asp Lys Asp Asp Met Ser Arg Xaa Leu Leu Ala Met Ser 
305                 310                 315                 320 


Ser Ser Gln Asp Ser Cys Ile Ser Met Arg Gln Ser Gly Cys Leu Pro 
                325                 330                 335     


Leu Leu Ile Gln Leu Leu His Gly Asn Asp Lys Asp Ser Val Leu Leu 
            340                 345                 350         


Gly Asn Ser Arg Gly Ser Lys Glu Ala Arg Ala Arg Ala Ser Ala Ala 
        355                 360                 365             


Leu His Asn Ile Ile His Ser Gln Pro Asp Asp Lys Arg Gly Arg Arg 
    370                 375                 380                 


Glu Ile Arg Val Leu His Leu Leu Glu Gln Ile Arg Ala Tyr Cys Glu 
385                 390                 395                 400 


Xaa Cys Trp Glu Trp Gln Glu Ala His Glu Pro Gly Met Asp Gln Asp 
                405                 410                 415     


Lys Asn Pro Met Pro Ala Pro Val Glu His Gln Ile Cys Pro Ala Val 
            420                 425                 430         


Cys Val Leu Met Lys Leu Ser Phe Asp Glu Glu His Arg His Ala Met 
        435                 440                 445             


Asn Glu Leu Gly Gly Leu Gln Ala Ile Ala Glu Leu Leu Gln Val Asp 
    450                 455                 460                 


Cys Glu Met Tyr Gly Leu Xaa Asn Asp His Tyr Ser Ile Xaa Leu Arg 
465                 470                 475                 480 


Arg Tyr Ala Gly Met Ala Leu Xaa Asn Leu Xaa Phe Gly Asp Val Ala 
                485                 490                 495     


Asn Lys Ala Xaa Leu Cys Ser Met Lys Gly Cys Met Arg Ala Leu Val 
            500                 505                 510         


Ala Gln Leu Lys Ser Glu Ser Glu Asp Leu Gln Gln Val Ile Ala Ser 
        515                 520                 525             


Val Leu Arg Asn Leu Ser Trp Arg Ala Asp Val Asn Ser Lys Lys Xaa 
    530                 535                 540                 


Leu Arg Glu Val Gly Ser Val Lys Ala Leu Met Glu Cys Ala Leu Glu 
545                 550                 555                 560 


Val Lys Lys Glu Ser Xaa Leu Lys Ser Val Leu Ser Ala Leu Trp Asn 
                565                 570                 575     


Leu Ser Ala His Cys Xaa Glu Asn Lys Ala Asp Ile Cys Ala Val Asp 
            580                 585                 590         


Gly Ala Leu Ala Phe Leu Val Gly Xaa Leu Xaa Tyr Arg Ser Gln Xaa 
        595                 600                 605             


Asn Xaa Leu Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg Asn Val 
    610                 615                 620                 


Ser Ser Leu Ile Ala Xaa Asn Glu Asp His Arg Gln Ile Leu Arg Glu 
625                 630                 635                 640 


Asn Asn Cys Leu Gln Xaa Leu Leu Gln His Leu Lys Ser His Ser Leu 
                645                 650                 655     


Xaa Ile Val Ser Asn Ala Cys Gly Xaa Leu Trp Asn Leu Ser Ala Arg 
            660                 665                 670         


Asn Pro Lys Asp Gln Glu Ala Leu Trp Asp Met Gly Ala Val Ser Met 
        675                 680                 685             


Leu Lys Asn Leu Ile His Ser Lys His Lys Met Ile Ala Met Gly Ser 
    690                 695                 700                 


Ala Ala Ala Leu Arg Asn Leu Met Ala Asn Arg Pro Ala Lys Tyr Lys 
705                 710                 715                 720 


Asp Ala Asn Ile Met Ser Pro Gly Ser Ser Leu Pro Ser Leu His Val 
                725                 730                 735     


Arg Lys Gln Lys Ala Leu Glu Ala Glu Leu Asp Ala Gln His Leu Ser 
            740                 745                 750         


Glu Xaa Phe Asp Asn Ile Asp Asn Leu Ser Pro Lys Ala Ser His Arg 
        755                 760                 765             


Ser Lys Gln Arg His Lys Gln Ser Leu Tyr Gly Asp Tyr Val Phe Asp 
    770                 775                 780                 


Xaa Asn Arg His Asp Asp Asn Arg Ser Asp Asn Phe Asn Xaa Gly Asn 
785                 790                 795                 800 


Met Xaa Val Leu Ser Pro Tyr Leu Asn Xaa Xaa Val Leu Pro Ser Ser 
                805                 810                 815     


Ser Ser Ser Arg Gly Ser Leu Asp Ser Ser Arg Ser Glu Lys Asp Arg 
            820                 825                 830         


Ser Leu Glu Arg Glu Arg Gly Ile Gly Leu Gly Asn Tyr His Pro Ala 
        835                 840                 845             


Xaa Glu Asn Pro Gly Xaa Ser Ser Lys Arg Gly Leu Gln Ile Ser Xaa 
    850                 855                 860                 


Xaa Ala Ala Gln Ile Ala Lys Val Met Glu Glu Val Ser Ala Ile His 
865                 870                 875                 880 


Xaa Ser Gln Glu Asp Arg Ser Ser Gly Ser Xaa Xaa Glu Leu His Cys 
                885                 890                 895     


Val Xaa Asp Glu Arg Asn Ala Leu Arg Arg Ser Ser Ala Ala His Xaa 
            900                 905                 910         


His Ser Asn Xaa Tyr Asn Phe Xaa Lys Ser Glu Asn Ser Asn Arg Xaa 
        915                 920                 925             


Cys Ser Met Pro Tyr Ala Lys Leu Glu Tyr Lys Arg Ser Ser Asn Asp 
    930                 935                 940                 


Ser Leu Asn Ser Val Ser Ser Ser Asp Gly Tyr Gly Lys Arg Gly Gln 
945                 950                 955                 960 


Met Lys Pro Ser Ile Glu Ser Tyr Ser Glu Asp Asp Glu Ser Lys Phe 
                965                 970                 975     


Cys Ser Tyr Gly Gln Tyr Pro Ala Asp Leu Ala His Lys Ile His Ser 
            980                 985                 990         


Ala Asn His Met Asp Asp Asn Asp  Gly Glu Leu Asp Xaa  Pro Ile Asn 
        995                 1000                 1005             


Tyr Ser  Leu Lys Tyr Ser Asp  Glu Gln Leu Asn Ser  Gly Arg Gln 
    1010                 1015                 1020             


Ser Pro  Ser Gln Asn Glu Arg  Trp Ala Arg Pro Lys  His Ile Ile 
    1025                 1030                 1035             


Glu Asp  Glu Ile Lys Gln Ser  Glu Gln Arg Gln Ser  Arg Asn Gln 
    1040                 1045                 1050             


Ser Xaa  Xaa Tyr Pro Val Tyr  Xaa Glu Ser Xaa Asp  Asp Lys His 
    1055                 1060                 1065             


Leu Lys  Phe Gln Pro His Phe  Gly Gln Gln Glu Cys  Val Ser Pro 
    1070                 1075                 1080             


Tyr Arg  Ser Arg Gly Ala Asn  Gly Ser Glu Xaa Asn  Arg Val Gly 
    1085                 1090                 1095             


Ser Asn  His Gly Ile Asn Gln  Asn Val Ser Gln Ser  Leu Cys Gln 
    1100                 1105                 1110             


Glu Asp  Asp Tyr Glu Asp Asp  Lys Pro Xaa Asn Tyr  Ser Glu Arg 
    1115                 1120                 1125             


Tyr Ser  Glu Glu Glu Gln His  
    1130                 1135 


<210> 2535
<211> 58
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<400> 2535
Met Tyr Ala Ser Leu Gly Ser Gly Pro Val Ala Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Pro Pro Ser Val Leu Gly Ser Trp Ser Xaa Gly Gly Ser Arg Ser 
            20                  25                  30          


Cys Val Arg Gln Glu Xaa Lys Ser Pro Gly Gly Ala Arg Xaa Ser Gly 
        35                  40                  45              


His Trp Ala Ser Val Trp Gln Val Gln Gly 
    50                  55              


<210> 2536
<211> 51
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<400> 2536
Xaa Pro Ala Pro Val Glu His Gln Ile Cys Pro Ala Val Cys Val Leu 
1               5                   10                  15      


Met Lys Leu Ser Phe Asp Glu Glu His Arg His Ala Met Asn Glu Leu 
            20                  25                  30          


Gly Ile Asn Pro Gln Lys Arg Ile Glu Cys Leu Met Glu Phe Val Ser 
        35                  40                  45              


Xaa Leu His 
    50      


<210> 2537
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 2537
Met Ala Ser Ser Val Ala Pro Tyr Glu Gln Leu Val Arg Gln Val Glu 
1               5                   10                  15      


Ala Leu Lys Ala Glu Asn Ser His Leu Arg Gln Glu Leu Arg Asp Asn 
            20                  25                  30          


Ser Ser His Leu Ser Lys Leu Glu Xaa Glu Xaa Ser Gly Met Lys Glu 
        35                  40                  45              


Val Leu Lys His Leu Gln Gly Lys Leu Glu Gln Glu Ala Arg Val Leu 
    50                  55                  60                  


Val Ser Ser Gly Gln Xaa Glu Val Leu Glu Gln Leu Lys Ala Leu Gln 
65                  70                  75                  80  


Met Asp Ile Xaa Ser Leu Tyr Asn Leu Lys Phe Gln Pro Pro Xaa Leu 
                85                  90                  95      


Gly Pro Glu Pro Ala Ala Arg Xaa Pro Glu Gly Ser Pro Val His Gly 
            100                 105                 110         


Ser Gly Pro Ser Lys Asp Ser Phe Gly Glu Leu Ser Arg Ala Xaa Ile 
        115                 120                 125             


Arg Leu Leu Glu Glu Leu Asp Arg Glu Arg 
    130                 135             


<210> 2538
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 2538
Met Ala Ser Ser Val Ala Pro Tyr Glu Gln Leu Val Arg Gln Val Glu 
1               5                   10                  15      


Ala Leu Lys Ala Glu Asn Ser His Leu Arg Gln Glu Leu Arg Asp Asn 
            20                  25                  30          


Ser Ser His Leu Ser Lys Leu Glu Xaa Glu Xaa Ser Gly Met Lys Glu 
        35                  40                  45              


Val Leu Lys His Leu Gln Gly Lys Leu Glu Gln Glu Ala Arg Val Leu 
    50                  55                  60                  


Val Ser Ser Gly Gln Xaa Glu Val Leu Glu Gln Leu Lys Ala Leu Gln 
65                  70                  75                  80  


Met Asp Ile Xaa Ser Leu Tyr Asn Leu Lys Phe Gln Pro Pro Xaa Leu 
                85                  90                  95      


Gly Pro Glu Pro Ala Ala Arg Xaa Pro Glu Gly Ser Pro Val His Gly 
            100                 105                 110         


Ser Gly Pro Ser Lys Asp Ser Phe Gly Glu Leu Ser Arg Ala Xaa Ile 
        115                 120                 125             


Arg Leu Leu Glu Glu Leu Asp Arg Glu Arg Cys Phe Leu Leu Asn Glu 
    130                 135                 140                 


Ile Glu Lys Glu Glu Lys Glu Lys Leu Trp Tyr Tyr Ser Gln Leu Gln 
145                 150                 155                 160 


Gly Leu Ser Lys Arg Leu Asp Glu Leu Pro 
                165                 170 


<210> 2539
<211> 194
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<400> 2539
Met Ala Ser Ser Val Ala Pro Tyr Glu Gln Leu Val Arg Gln Val Glu 
1               5                   10                  15      


Ala Leu Lys Ala Glu Asn Ser His Leu Arg Gln Glu Leu Arg Asp Asn 
            20                  25                  30          


Ser Ser His Leu Ser Lys Leu Glu Xaa Glu Xaa Ser Gly Met Lys Glu 
        35                  40                  45              


Val Leu Lys His Leu Gln Gly Lys Leu Glu Gln Glu Ala Arg Val Leu 
    50                  55                  60                  


Val Ser Ser Gly Gln Xaa Glu Val Leu Glu Gln Leu Lys Ala Leu Gln 
65                  70                  75                  80  


Met Asp Ile Xaa Ser Leu Tyr Asn Leu Lys Phe Gln Pro Pro Xaa Leu 
                85                  90                  95      


Gly Pro Glu Pro Ala Ala Arg Xaa Pro Glu Gly Ser Pro Val His Gly 
            100                 105                 110         


Ser Gly Pro Ser Lys Asp Ser Phe Gly Glu Leu Ser Arg Ala Xaa Ile 
        115                 120                 125             


Arg Leu Leu Glu Glu Leu Asp Arg Glu Arg Cys Phe Leu Leu Asn Glu 
    130                 135                 140                 


Ile Glu Lys Glu Glu Lys Glu Lys Leu Trp Tyr Tyr Ser Gln Leu Gln 
145                 150                 155                 160 


Gly Leu Ser Lys Arg Leu Asp Glu Leu Pro His Val Glu Xaa Phe Ser 
                165                 170                 175     


Met Gln Met Asp Leu Ile Arg Gln Gln Leu Glu Phe Glu Ala Gln His 
            180                 185                 190         


Ile Arg 
        


<210> 2540
<211> 731
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<400> 2540
Met Ala Ser Ser Val Ala Pro Tyr Glu Gln Leu Val Arg Gln Val Glu 
1               5                   10                  15      


Ala Leu Lys Ala Glu Asn Ser His Leu Arg Gln Glu Leu Arg Asp Asn 
            20                  25                  30          


Ser Ser His Leu Ser Lys Leu Glu Xaa Glu Xaa Ser Gly Met Lys Glu 
        35                  40                  45              


Val Leu Lys His Leu Gln Gly Lys Leu Glu Gln Glu Ala Arg Val Leu 
    50                  55                  60                  


Val Ser Ser Gly Gln Xaa Glu Val Leu Glu Gln Leu Lys Ala Leu Gln 
65                  70                  75                  80  


Met Asp Ile Xaa Ser Leu Tyr Asn Leu Lys Phe Gln Pro Pro Xaa Leu 
                85                  90                  95      


Gly Pro Glu Pro Ala Ala Arg Xaa Pro Glu Gly Ser Pro Val His Gly 
            100                 105                 110         


Ser Gly Pro Ser Lys Asp Ser Phe Gly Glu Leu Ser Arg Ala Xaa Ile 
        115                 120                 125             


Arg Leu Leu Glu Glu Leu Asp Arg Glu Arg Cys Phe Leu Leu Asn Glu 
    130                 135                 140                 


Ile Glu Lys Glu Glu Lys Glu Lys Leu Trp Tyr Tyr Ser Gln Leu Gln 
145                 150                 155                 160 


Gly Leu Ser Lys Arg Leu Asp Glu Leu Pro His Val Glu Xaa Phe Ser 
                165                 170                 175     


Met Gln Met Asp Leu Ile Arg Gln Gln Leu Glu Phe Glu Ala Gln His 
            180                 185                 190         


Ile Arg Ser Leu Met Glu Glu Arg Phe Gly Xaa Ser Asp Glu Met Val 
        195                 200                 205             


Gln Arg Ala Gln Ile Arg Ala Ser Arg Leu Glu Gln Ile Asp Lys Glu 
    210                 215                 220                 


Leu Leu Glu Ala Gln Asp Arg Val Gln Gln Xaa Glu Pro Gln Ala Leu 
225                 230                 235                 240 


Leu Ala Val Lys Ser Val Pro Val Asp Glu Asp Pro Glu Xaa Glu Val 
                245                 250                 255     


Pro Xaa His Pro Glu Asp Gly Xaa Pro Gln Pro Gly Asn Ser Lys Val 
            260                 265                 270         


Glu Val Val Phe Trp Leu Leu Ser Met Leu Ala Xaa Arg Asp Gln Glu 
        275                 280                 285             


Asp Xaa Ala Arg Xaa Leu Leu Ala Met Ser Ser Ser Pro Glu Ser Cys 
    290                 295                 300                 


Val Ala Met Arg Arg Ser Gly Cys Leu Pro Leu Leu Leu Gln Ile Leu 
305                 310                 315                 320 


His Gly Xaa Glu Ala Ala Ala Gly Gly Arg Ala Gly Ala Pro Gly Ala 
                325                 330                 335     


Pro Gly Ala Lys Asp Ala Arg Met Arg Ala Asn Ala Ala Leu His Asn 
            340                 345                 350         


Ile Val Phe Ser Gln Pro Asp Gln Gly Leu Ala Arg Lys Glu Met Arg 
        355                 360                 365             


Val Leu His Val Leu Glu Gln Ile Arg Ala Tyr Cys Glu Xaa Cys Trp 
    370                 375                 380                 


Asp Trp Leu Gln Ala Arg Asp Gly Gly Pro Glu Gly Gly Gly Ala Gly 
385                 390                 395                 400 


Ser Ala Pro Ile Pro Ile Glu Pro Gln Ile Cys Gln Ala Xaa Cys Ala 
                405                 410                 415     


Val Met Lys Leu Ser Phe Asp Glu Glu Tyr Arg Arg Ala Met Asn Glu 
            420                 425                 430         


Leu Gly Gly Leu Gln Ala Val Ala Glu Leu Leu Gln Val Asp Tyr Glu 
        435                 440                 445             


Met His Lys Met Xaa Arg Asp Pro Leu Asn Leu Ala Leu Arg Arg Tyr 
    450                 455                 460                 


Ala Gly Met Xaa Leu Xaa Asn Leu Xaa Phe Gly Asp Val Ala Asn Lys 
465                 470                 475                 480 


Ala Xaa Leu Cys Ala Arg Arg Gly Cys Met Glu Ala Ile Val Ala Gln 
                485                 490                 495     


Leu Ala Ser Asp Ser Glu Glu Leu His Gln Val Val Ser Ser Ile Leu 
            500                 505                 510         


Arg Asn Leu Ser Trp Arg Ala Asp Ile Asn Ser Lys Lys Val Leu Arg 
        515                 520                 525             


Glu Ala Gly Ser Val Xaa Ala Leu Val Gln Cys Val Leu Arg Ala Xaa 
    530                 535                 540                 


Lys Glu Ser Xaa Leu Lys Ser Val Leu Ser Ala Leu Trp Asn Leu Ser 
545                 550                 555                 560 


Ala His Ser Xaa Glu Asn Lys Ala Ala Ile Cys Gln Val Asp Gly Ala 
                565                 570                 575     


Leu Gly Phe Leu Val Ser Xaa Leu Xaa Tyr Lys Cys Gln Ser Asn Ser 
            580                 585                 590         


Leu Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg Asn Val Ser Ser 
        595                 600                 605             


Leu Val Ala Xaa Arg Glu Asp Tyr Arg Gln Val Leu Arg Asp His Asn 
    610                 615                 620                 


Cys Leu Gln Xaa Leu Leu Gln His Leu Xaa Ser His Ser Leu Xaa Ile 
625                 630                 635                 640 


Val Ser Asn Ala Cys Gly Xaa Leu Trp Asn Leu Ser Ala Arg Ser Ala 
                645                 650                 655     


Arg Asp Gln Glu Leu Leu Trp Asp Leu Gly Ala Val Gly Met Leu Arg 
            660                 665                 670         


Asn Leu Val His Ser Lys His Lys Met Ile Ala Met Gly Ser Ala Ala 
        675                 680                 685             


Ala Leu Arg Asn Leu Leu Ala His Arg Pro Ala Lys His Gln Ala Ala 
    690                 695                 700                 


Ala Xaa Ala Val Ser Pro Gly Ser Cys Val Pro Ser Leu Tyr Val Arg 
705                 710                 715                 720 


Lys Gln Arg Ala Leu Glu Ala Glu Leu Asp Ala 
                725                 730     


<210> 2541
<211> 702
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<400> 2541
Met Ala Ser Ser Val Ala Pro Tyr Glu Gln Leu Val Arg Gln Val Glu 
1               5                   10                  15      


Ala Leu Lys Ala Glu Asn Ser His Leu Arg Gln Glu Leu Arg Asp Asn 
            20                  25                  30          


Ser Ser His Leu Ser Lys Leu Glu Xaa Glu Xaa Ser Gly Met Lys Glu 
        35                  40                  45              


Val Leu Lys His Leu Gln Gly Lys Leu Glu Gln Glu Ala Arg Val Leu 
    50                  55                  60                  


Val Ser Ser Gly Gln Xaa Glu Val Leu Glu Gln Leu Lys Ala Leu Gln 
65                  70                  75                  80  


Met Asp Ile Xaa Ser Leu Tyr Asn Leu Lys Phe Gln Pro Pro Xaa Leu 
                85                  90                  95      


Gly Pro Glu Pro Ala Ala Arg Xaa Pro Glu Gly Ser Pro Val His Gly 
            100                 105                 110         


Ser Gly Pro Ser Lys Asp Ser Phe Gly Glu Leu Ser Arg Ala Xaa Ile 
        115                 120                 125             


Arg Leu Leu Glu Glu Leu Asp Arg Glu Arg Cys Phe Leu Leu Asn Glu 
    130                 135                 140                 


Ile Glu Lys Glu Glu Lys Glu Lys Leu Trp Tyr Tyr Ser Gln Leu Gln 
145                 150                 155                 160 


Gly Leu Ser Lys Arg Leu Asp Glu Leu Pro His Val Glu Xaa Gln Phe 
                165                 170                 175     


Ser Met Gln Met Asp Leu Ile Arg Gln Gln Leu Glu Phe Glu Ala Gln 
            180                 185                 190         


His Ile Arg Ser Leu Met Glu Glu Arg Phe Gly Xaa Ser Asp Glu Met 
        195                 200                 205             


Val Gln Arg Ala Gln Ile Arg Ala Ser Arg Leu Glu Gln Ile Asp Lys 
    210                 215                 220                 


Glu Leu Leu Glu Ala Gln Asp Arg Val Gln Gln Xaa Glu Pro Gln Ala 
225                 230                 235                 240 


Leu Leu Ala Val Lys Ser Val Pro Val Asp Glu Asp Pro Glu Xaa Glu 
                245                 250                 255     


Val Pro Xaa His Pro Glu Asp Gly Xaa Pro Gln Pro Gly Asn Ser Lys 
            260                 265                 270         


Val Glu Val Val Phe Trp Leu Leu Ser Met Leu Ala Xaa Arg Asp Gln 
        275                 280                 285             


Glu Asp Xaa Ala Arg Xaa Leu Leu Ala Met Ser Ser Ser Pro Glu Ser 
    290                 295                 300                 


Cys Val Ala Met Arg Arg Ser Gly Cys Leu Pro Leu Leu Leu Gln Ile 
305                 310                 315                 320 


Leu His Gly Xaa Glu Ala Ala Ala Gly Gly Arg Ala Gly Ala Pro Gly 
                325                 330                 335     


Ala Pro Gly Ala Lys Asp Ala Arg Met Arg Ala Asn Ala Ala Leu His 
            340                 345                 350         


Asn Ile Val Phe Ser Gln Pro Asp Gln Gly Leu Ala Arg Lys Glu Met 
        355                 360                 365             


Arg Val Leu His Val Leu Glu Gln Ile Arg Ala Tyr Cys Glu Xaa Cys 
    370                 375                 380                 


Trp Asp Trp Leu Gln Ala Arg Asp Gly Gly Pro Glu Gly Gly Gly Ala 
385                 390                 395                 400 


Gly Ser Ala Pro Ile Pro Ile Glu Pro Gln Ile Cys Gln Ala Xaa Cys 
                405                 410                 415     


Ala Val Met Lys Leu Ser Phe Asp Glu Glu Tyr Arg Arg Ala Met Asn 
            420                 425                 430         


Glu Leu Gly Gly Leu Gln Ala Val Ala Glu Leu Leu Gln Val Asp Tyr 
        435                 440                 445             


Glu Met His Lys Met Xaa Arg Asp Pro Leu Asn Leu Ala Leu Arg Arg 
    450                 455                 460                 


Tyr Ala Gly Met Xaa Leu Xaa Asn Leu Xaa Phe Gly Asp Val Ala Asn 
465                 470                 475                 480 


Lys Ala Xaa Leu Cys Ala Arg Arg Gly Cys Met Glu Ala Ile Val Ala 
                485                 490                 495     


Gln Leu Ala Ser Asp Ser Glu Glu Leu His Gln Val Val Ser Ser Ile 
            500                 505                 510         


Leu Arg Asn Leu Ser Trp Arg Ala Asp Ile Asn Ser Lys Lys Val Leu 
        515                 520                 525             


Arg Glu Ala Gly Ser Val Xaa Ala Leu Val Gln Cys Val Leu Arg Ala 
    530                 535                 540                 


Xaa Lys Glu Ser Xaa Leu Lys Ser Val Leu Ser Ala Leu Trp Asn Leu 
545                 550                 555                 560 


Ser Ala His Ser Xaa Glu Asn Lys Ala Ala Ile Cys Gln Val Asp Gly 
                565                 570                 575     


Ala Leu Gly Phe Leu Val Ser Xaa Leu Xaa Tyr Lys Cys Gln Ser Asn 
            580                 585                 590         


Ser Leu Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg Asn Val Ser 
        595                 600                 605             


Ser Leu Val Ala Xaa Arg Glu Asp Tyr Arg Gln Val Leu Arg Asp His 
    610                 615                 620                 


Asn Cys Leu Gln Xaa Leu Leu Gln His Leu Xaa Ser His Ser Leu Xaa 
625                 630                 635                 640 


Ile Val Ser Asn Ala Cys Gly Xaa Leu Trp Asn Leu Ser Ala Arg Ser 
                645                 650                 655     


Ala Arg Asp Gln Glu Leu Leu Trp Asp Leu Gly Ala Val Gly Met Leu 
            660                 665                 670         


Arg Asn Leu Val His Ser Lys His Lys Met Ile Ala Met Gly Ser Ala 
        675                 680                 685             


Ala Ala Leu Arg Asn Leu Leu Ala His Arg Pro Ala Lys His 
    690                 695                 700         


<210> 2542
<211> 2303
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1120)..(1120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1213)..(1213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1328)..(1328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1396)..(1396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1410)..(1410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1429)..(1429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1433)..(1433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1487)..(1487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1499)..(1500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1502)..(1502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1524)..(1524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1526)..(1526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1530)..(1530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1538)..(1538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1564)..(1564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1655)..(1655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1698)..(1698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1707)..(1707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1729)..(1729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1777)..(1777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1780)..(1781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1792)..(1792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1808)..(1808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1814)..(1814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1849)..(1849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1854)..(1854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1863)..(1863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1871)..(1871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1879)..(1879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1894)..(1894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1911)..(1911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1915)..(1915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1923)..(1923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1959)..(1959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1996)..(1996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2076)..(2077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2095)..(2095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2144)..(2145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2161)..(2161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2165)..(2165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2173)..(2173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2186)..(2186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2193)..(2193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2201)..(2201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2205)..(2205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2211)..(2211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2285)..(2286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2296)..(2296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2300)..(2300)
<223> Selenocysteine

<400> 2542
Met Ala Ser Ser Val Ala Pro Tyr Glu Gln Leu Val Arg Gln Val Glu 
1               5                   10                  15      


Ala Leu Lys Ala Glu Asn Ser His Leu Arg Gln Glu Leu Arg Asp Asn 
            20                  25                  30          


Ser Ser His Leu Ser Lys Leu Glu Xaa Glu Xaa Ser Gly Met Lys Glu 
        35                  40                  45              


Val Leu Lys His Leu Gln Gly Lys Leu Glu Gln Glu Ala Arg Val Leu 
    50                  55                  60                  


Val Ser Ser Gly Gln Xaa Glu Val Leu Glu Gln Leu Lys Ala Leu Gln 
65                  70                  75                  80  


Met Asp Ile Xaa Ser Leu Tyr Asn Leu Lys Phe Gln Pro Pro Xaa Leu 
                85                  90                  95      


Gly Pro Glu Pro Ala Ala Arg Xaa Pro Glu Gly Ser Pro Val His Gly 
            100                 105                 110         


Ser Gly Pro Ser Lys Asp Ser Phe Gly Glu Leu Ser Arg Ala Xaa Ile 
        115                 120                 125             


Arg Leu Leu Glu Glu Leu Asp Arg Glu Arg Cys Phe Leu Leu Asn Glu 
    130                 135                 140                 


Ile Glu Lys Glu Glu Lys Glu Lys Leu Trp Tyr Tyr Ser Gln Leu Gln 
145                 150                 155                 160 


Gly Leu Ser Lys Arg Leu Asp Glu Leu Pro His Val Glu Xaa Gln Phe 
                165                 170                 175     


Ser Met Gln Met Asp Leu Ile Arg Gln Gln Leu Glu Phe Glu Ala Gln 
            180                 185                 190         


His Ile Arg Ser Leu Met Glu Glu Arg Phe Gly Xaa Ser Asp Glu Met 
        195                 200                 205             


Val Gln Arg Ala Gln Ile Arg Ala Ser Arg Leu Glu Gln Ile Asp Lys 
    210                 215                 220                 


Glu Leu Leu Glu Ala Gln Asp Arg Val Gln Gln Xaa Glu Pro Gln Ala 
225                 230                 235                 240 


Leu Leu Ala Val Lys Ser Val Pro Val Asp Glu Asp Pro Glu Xaa Glu 
                245                 250                 255     


Val Pro Xaa His Pro Glu Asp Gly Xaa Pro Gln Pro Gly Asn Ser Lys 
            260                 265                 270         


Val Glu Val Val Phe Trp Leu Leu Ser Met Leu Ala Xaa Arg Asp Gln 
        275                 280                 285             


Glu Asp Xaa Ala Arg Xaa Leu Leu Ala Met Ser Ser Ser Pro Glu Ser 
    290                 295                 300                 


Cys Val Ala Met Arg Arg Ser Gly Cys Leu Pro Leu Leu Leu Gln Ile 
305                 310                 315                 320 


Leu His Gly Xaa Glu Ala Ala Ala Gly Gly Arg Ala Gly Ala Pro Gly 
                325                 330                 335     


Ala Pro Gly Ala Lys Asp Ala Arg Met Arg Ala Asn Ala Ala Leu His 
            340                 345                 350         


Asn Ile Val Phe Ser Gln Pro Asp Gln Gly Leu Ala Arg Lys Glu Met 
        355                 360                 365             


Arg Val Leu His Val Leu Glu Gln Ile Arg Ala Tyr Cys Glu Xaa Cys 
    370                 375                 380                 


Trp Asp Trp Leu Gln Ala Arg Asp Gly Gly Pro Glu Gly Gly Gly Ala 
385                 390                 395                 400 


Gly Ser Ala Pro Ile Pro Ile Glu Pro Gln Ile Cys Gln Ala Xaa Cys 
                405                 410                 415     


Ala Val Met Lys Leu Ser Phe Asp Glu Glu Tyr Arg Arg Ala Met Asn 
            420                 425                 430         


Glu Leu Gly Gly Leu Gln Ala Val Ala Glu Leu Leu Gln Val Asp Tyr 
        435                 440                 445             


Glu Met His Lys Met Xaa Arg Asp Pro Leu Asn Leu Ala Leu Arg Arg 
    450                 455                 460                 


Tyr Ala Gly Met Xaa Leu Xaa Asn Leu Xaa Phe Gly Asp Val Ala Asn 
465                 470                 475                 480 


Lys Ala Xaa Leu Cys Ala Arg Arg Gly Cys Met Glu Ala Ile Val Ala 
                485                 490                 495     


Gln Leu Ala Ser Asp Ser Glu Glu Leu His Gln Val Val Ser Ser Ile 
            500                 505                 510         


Leu Arg Asn Leu Ser Trp Arg Ala Asp Ile Asn Ser Lys Lys Val Leu 
        515                 520                 525             


Arg Glu Ala Gly Ser Val Xaa Ala Leu Val Gln Cys Val Leu Arg Ala 
    530                 535                 540                 


Xaa Lys Glu Ser Xaa Leu Lys Ser Val Leu Ser Ala Leu Trp Asn Leu 
545                 550                 555                 560 


Ser Ala His Ser Xaa Glu Asn Lys Ala Ala Ile Cys Gln Val Asp Gly 
                565                 570                 575     


Ala Leu Gly Phe Leu Val Ser Xaa Leu Xaa Tyr Lys Cys Gln Ser Asn 
            580                 585                 590         


Ser Leu Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg Asn Val Ser 
        595                 600                 605             


Ser Leu Val Ala Xaa Arg Glu Asp Tyr Arg Gln Val Leu Arg Asp His 
    610                 615                 620                 


Asn Cys Leu Gln Xaa Leu Leu Gln His Leu Xaa Ser His Ser Leu Xaa 
625                 630                 635                 640 


Ile Val Ser Asn Ala Cys Gly Xaa Leu Trp Asn Leu Ser Ala Arg Ser 
                645                 650                 655     


Ala Arg Asp Gln Glu Leu Leu Trp Asp Leu Gly Ala Val Gly Met Leu 
            660                 665                 670         


Arg Asn Leu Val His Ser Lys His Lys Met Ile Ala Met Gly Ser Ala 
        675                 680                 685             


Ala Ala Leu Arg Asn Leu Leu Ala His Arg Pro Ala Lys His Gln Ala 
    690                 695                 700                 


Ala Ala Xaa Ala Val Ser Pro Gly Ser Cys Val Pro Ser Leu Tyr Val 
705                 710                 715                 720 


Arg Lys Gln Arg Ala Leu Glu Ala Glu Leu Asp Ala Arg His Leu Ala 
                725                 730                 735     


Gln Ala Leu Glu His Leu Glu Lys Gln Gly Pro Pro Ala Ala Glu Ala 
            740                 745                 750         


Ala Xaa Lys Lys Pro Leu Pro Pro Leu Arg His Leu Asp Gly Leu Ala 
        755                 760                 765             


Gln Asp Tyr Ala Ser Asp Ser Gly Cys Phe Asp Asp Asp Asp Ala Pro 
    770                 775                 780                 


Ser Ser Leu Ala Ala Ala Ala Ala Xaa Gly Glu Pro Ala Ser Pro Ala 
785                 790                 795                 800 


Ala Leu Ser Leu Phe Leu Gly Ser Pro Phe Leu Gln Gly Gln Ala Leu 
                805                 810                 815     


Ala Arg Xaa Pro Pro Xaa Arg Arg Gly Gly Lys Glu Ala Glu Lys Asp 
            820                 825                 830         


Xaa Ser Gly Glu Ala Ala Val Ala Ala Lys Ala Lys Ala Lys Leu Ala 
        835                 840                 845             


Leu Ala Val Ala Arg Ile Asp Gln Leu Val Glu Asp Ile Ser Ala Leu 
    850                 855                 860                 


His Xaa Ser Ser Asp Asp Ser Phe Ser Leu Ser Ser Gly Asp Pro Gly 
865                 870                 875                 880 


Gln Glu Ala Pro Arg Glu Gly Arg Ala Gln Ser Cys Ser Pro Cys Arg 
                885                 890                 895     


Gly Pro Glu Gly Gly Arg Arg Glu Ala Gly Ser Arg Ala His Pro Leu 
            900                 905                 910         


Leu Arg Leu Lys Ala Ala His Ala Ser Leu Ser Asn Asp Ser Leu Asn 
        915                 920                 925             


Ser Gly Ser Ala Ser Asp Gly Tyr Cys Pro Arg Glu His Met Leu Pro 
    930                 935                 940                 


Cys Pro Leu Ala Ala Leu Ala Ser Arg Arg Glu Asp Pro Arg Cys Gly 
945                 950                 955                 960 


Gln Pro Arg Pro Ser Arg Leu Asp Leu Asp Leu Pro Gly Cys Gln Ala 
                965                 970                 975     


Glu Pro Pro Ala Arg Glu Ala Xaa Ser Ala Asp Ala Arg Val Arg Xaa 
            980                 985                 990         


Ile Lys Leu Ser Pro Xaa Tyr Gln  His Val Pro Leu Leu  Glu Gly Ala 
        995                 1000                 1005             


Ser Arg  Ala Gly Ala Glu Pro  Leu Ala Gly Pro Gly  Ile Ser Pro 
    1010                 1015                 1020             


Gly Ala  Arg Lys Gln Ala Trp  Leu Pro Ala Asp His  Leu Ser Lys 
    1025                 1030                 1035             


Val Pro  Glu Lys Leu Ala Ala  Ala Pro Leu Ser Val  Ala Ser Lys 
    1040                 1045                 1050             


Ala Leu  Gln Lys Leu Ala Ala  Gln Glu Gly Pro Leu  Ser Leu Ser 
    1055                 1060                 1065             


Arg Cys  Ser Ser Leu Ser Ser  Leu Ser Ser Ala Gly  Arg Pro Gly 
    1070                 1075                 1080             


Pro Ser  Glu Gly Gly Asp Leu  Asp Asp Ser Asp Ser  Ser Leu Glu 
    1085                 1090                 1095             


Gly Leu  Glu Glu Ala Gly Pro  Ser Glu Ala Glu Leu  Asp Ser Xaa 
    1100                 1105                 1110             


Trp Arg  Ala Pro Gly Ala Xaa  Ser Leu Pro Val Ala  Ile Pro Ala 
    1115                 1120                 1125             


Pro Arg  Arg Asn Arg Gly Arg  Gly Leu Gly Val Glu  Asp Ala Xaa 
    1130                 1135                 1140             


Pro Ser  Ser Ser Ser Glu Asn  Tyr Val Gln Glu Xaa  Pro Leu Val 
    1145                 1150                 1155             


Leu Ser  Arg Cys Ser Ser Val  Ser Ser Leu Gly Ser  Phe Glu Ser 
    1160                 1165                 1170             


Pro Ser  Ile Ala Ser Ser Ile  Pro Ser Glu Pro Cys  Ser Gly Gln 
    1175                 1180                 1185             


Gly Ser  Gly Xaa Ile Ser Pro  Ser Glu Leu Pro Asp  Ser Pro Gly 
    1190                 1195                 1200             


Gln Xaa  Met Pro Pro Ser Arg  Ser Lys Xaa Pro Pro  Leu Ala Pro 
    1205                 1210                 1215             


Ala Pro  Gln Gly Pro Pro Glu  Ala Xaa Gln Phe Ser  Leu Gln Trp 
    1220                 1225                 1230             


Glu Ser  Tyr Val Lys Arg Phe  Leu Asp Ile Ala Asp  Cys Arg Glu 
    1235                 1240                 1245             


Arg Cys  Arg Leu Pro Ser Glu  Leu Asp Ala Gly Ser  Val Arg Phe 
    1250                 1255                 1260             


Xaa Val  Glu Lys Pro Asp Glu  Asn Phe Ser Cys Ala  Ser Ser Leu 
    1265                 1270                 1275             


Ser Ala  Leu Ala Leu His Glu  His Tyr Val Gln Gln  Asp Val Glu 
    1280                 1285                 1290             


Leu Arg  Leu Leu Pro Ser Ala  Cys Pro Glu Arg Gly  Gly Gly Ala 
    1295                 1300                 1305             


Gly Gly  Ala Gly Leu His Phe  Ala Gly His Arg Arg  Arg Glu Glu 
    1310                 1315                 1320             


Gly Pro  Ala Pro Xaa Gly Ser  Arg Pro Arg Gly Ala  Ala Asp Gln 
    1325                 1330                 1335             


Glu Leu  Glu Leu Leu Arg Glu  Cys Leu Gly Ala Ala  Val Pro Ala 
    1340                 1345                 1350             


Arg Leu  Arg Lys Val Ala Ser  Ala Leu Val Pro Gly  Arg Arg Ala 
    1355                 1360                 1365             


Leu Pro  Val Pro Val Tyr Met  Leu Val Pro Ala Pro  Ala Pro Ala 
    1370                 1375                 1380             


Gln Glu  Asp Asp Ser Cys Xaa  Asp Ser Ala Glu Gly  Xaa Pro Val 
    1385                 1390                 1395             


Asn Phe  Ser Ser Ala Ala Ser  Leu Ser Asp Glu Xaa  Leu Gln Gly 
    1400                 1405                 1410             


Pro Pro  Arg Asp Gln Pro Gly  Gly Pro Ala Gly Arg  Gln Arg Pro 
    1415                 1420                 1425             


Xaa Gly  Arg Pro Xaa Ser Ala  Arg Gln Ala Met Gly  His Arg His 
    1430                 1435                 1440             


Lys Ala  Gly Gly Ala Gly Arg  Ser Ala Glu Gln Ser  Arg Gly Ala 
    1445                 1450                 1455             


Gly Lys  Asn Arg Ala Gly Leu  Glu Leu Pro Leu Gly  Arg Pro Pro 
    1460                 1465                 1470             


Ser Ala  Pro Ala Asp Lys Asp  Gly Ser Lys Pro Gly  Arg Xaa Arg 
    1475                 1480                 1485             


Gly Asp  Gly Ala Leu Gln Ser  Leu Cys Leu Xaa Xaa  Pro Xaa Glu 
    1490                 1495                 1500             


Glu Ala  Val Tyr Cys Phe Tyr  Gly Asn Asp Ser Asp  Glu Glu Pro 
    1505                 1510                 1515             


Pro Ala  Ala Ala Pro Xaa Pro  Xaa His Arg Arg Xaa  Ser Ala Ile 
    1520                 1525                 1530             


Pro Arg  Ala Phe Xaa Arg Glu  Arg Pro Gln Gly Arg  Lys Glu Ala 
    1535                 1540                 1545             


Pro Ala  Pro Ser Lys Ala Ala  Pro Ala Ala Pro Pro  Pro Ala Arg 
    1550                 1555                 1560             


Xaa Gln  Pro Ser Leu Ile Ala  Asp Glu Xaa Pro Pro  Cys Tyr Ser 
    1565                 1570                 1575             


Leu Ser  Ser Ser Ala Ser Ser  Leu Ser Glu Pro Glu  Pro Ser Glu 
    1580                 1585                 1590             


Pro Pro  Ala Val His Pro Arg  Gly Arg Glu Pro Ala  Val Xaa Lys 
    1595                 1600                 1605             


Asp Pro  Gly Pro Gly Gly Gly  Arg Asp Ser Ser Pro  Ser Pro Arg 
    1610                 1615                 1620             


Ala Ala  Glu Glu Leu Leu Gln  Arg Cys Ile Ser Ser  Ala Leu Pro 
    1625                 1630                 1635             


Arg Arg  Arg Pro Pro Val Ser  Gly Leu Arg Arg Arg  Lys Pro Arg 
    1640                 1645                 1650             


Ala Xaa  Arg Leu Asp Glu Arg  Pro Ala Glu Gly Ser  Arg Glu Arg 
    1655                 1660                 1665             


Gly Glu  Glu Ala Ala Gly Ser  Asp Arg Ala Ser Asp  Leu Asp Ser 
    1670                 1675                 1680             


Val Glu  Trp Arg Ala Ile Gln  Glu Gly Ala Asn Ser  Ile Val Xaa 
    1685                 1690                 1695             


Trp Leu  His Gln Ala Ala Ala  Ala Xaa Arg Glu Ala  Ser Ser Glu 
    1700                 1705                 1710             


Ser Asp  Ser Ile Leu Ser Phe  Val Ser Gly Leu Ser  Val Gly Ser 
    1715                 1720                 1725             


Xaa Leu  Gln Pro Pro Lys His  Arg Lys Gly Arg Gln  Ala Glu Gly 
    1730                 1735                 1740             


Glu Met  Gly Ser Ala Arg Arg  Pro Glu Lys Arg Gly  Ala Ala Ser 
    1745                 1750                 1755             


Val Lys  Xaa Ser Gly Ser Pro  Arg Ser Pro Ala Gly  Pro Glu Lys 
    1760                 1765                 1770             


Pro Arg  Gly Xaa Gln Lys Xaa  Xaa Pro Gly Val Pro  Ala Val Leu 
    1775                 1780                 1785             


Arg Gly  Arg Xaa Val Ile Tyr  Val Pro Ser Pro Ala  Pro Arg Ala 
    1790                 1795                 1800             


Gln Pro  Lys Gly Xaa Pro Gly  Pro Arg Ala Xaa Pro  Arg Lys Val 
    1805                 1810                 1815             


Ala Pro  Pro Cys Leu Ala Gln  Pro Ala Ala Pro Ala  Lys Val Pro 
    1820                 1825                 1830             


Ser Pro  Gly Gln Gln Arg Ser  Arg Ser Leu His Arg  Pro Ala Lys 
    1835                 1840                 1845             


Xaa Ser  Glu Leu Ala Xaa Leu  Ser Gln Pro Pro Arg  Ser Ala Xaa 
    1850                 1855                 1860             


Pro Pro  Ala Arg Leu Ala Lys  Xaa Pro Ser Ser Ser  Ser Ser Gln 
    1865                 1870                 1875             


Xaa Ser  Pro Ala Ser Gln Pro  Leu Pro Arg Lys Arg  Pro Pro Val 
    1880                 1885                 1890             


Xaa Gln  Ala Ala Gly Ala Leu  Pro Gly Pro Gly Ala  Ser Pro Val 
    1895                 1900                 1905             


Pro Lys  Xaa Pro Ala Arg Xaa  Leu Leu Ala Lys Gln  His Lys Xaa 
    1910                 1915                 1920             


Gln Arg  Ser Pro Val Arg Ile  Pro Phe Met Gln Arg  Pro Ala Arg 
    1925                 1930                 1935             


Arg Gly  Pro Pro Pro Leu Ala  Arg Ala Val Pro Glu  Pro Gly Pro 
    1940                 1945                 1950             


Arg Gly  Arg Ala Gly Xaa Glu  Ala Gly Pro Gly Ala  Arg Gly Gly 
    1955                 1960                 1965             


Arg Leu  Gly Leu Val Arg Val  Ala Ser Ala Leu Ser  Ser Gly Ser 
    1970                 1975                 1980             


Glu Ser  Ser Asp Arg Ser Gly  Phe Arg Arg Gln Leu  Xaa Phe Ile 
    1985                 1990                 1995             


Lys Glu  Ser Pro Gly Leu Arg  Arg Arg Arg Ser Glu  Leu Ser Ser 
    2000                 2005                 2010             


Ala Glu  Ser Ala Ala Ser Ala  Pro Gln Gly Ala Ser  Pro Arg Arg 
    2015                 2020                 2025             


Gly Arg  Pro Ala Leu Pro Ala  Val Phe Leu Cys Ser  Ser Arg Cys 
    2030                 2035                 2040             


Glu Glu  Leu Arg Ala Ala Pro  Arg Gln Gly Pro Ala  Pro Ala Arg 
    2045                 2050                 2055             


Gln Arg  Pro Pro Ala Ala Arg  Pro Ser Pro Gly Glu  Arg Pro Ala 
    2060                 2065                 2070             


Arg Arg  Xaa Xaa Ser Glu Ser  Pro Ser Arg Leu Pro  Val Arg Ala 
    2075                 2080                 2085             


Pro Ala  Ala Arg Pro Glu Xaa  Val Lys Arg Tyr Ala  Ser Leu Pro 
    2090                 2095                 2100             


His Ile  Ser Val Ala Arg Arg  Pro Asp Gly Ala Val  Pro Ala Ala 
    2105                 2110                 2115             


Pro Ala  Ser Ala Asp Ala Ala  Arg Arg Ser Ser Asp  Gly Glu Pro 
    2120                 2125                 2130             


Arg Pro  Leu Pro Arg Val Ala  Ala Pro Gly Xaa Xaa  Trp Arg Arg 
    2135                 2140                 2145             


Ile Arg  Asp Glu Asp Val Pro  His Ile Leu Arg Ser  Xaa Leu Pro 
    2150                 2155                 2160             


Ala Xaa  Ala Leu Pro Leu Arg  Gly Ser Xaa Pro Glu  Asp Ala Pro 
    2165                 2170                 2175             


Ala Gly  Pro Pro Pro Arg Lys  Xaa Ser Asp Ala Val  Val Gln Xaa 
    2180                 2185                 2190             


Glu Glu  Val Ala Ala Pro Lys  Xaa Asn Ser Ser Xaa  Ser Pro Ser 
    2195                 2200                 2205             


Leu Glu  Xaa Arg Glu Pro Pro  Gly Ala Pro Ala Gly  Gly Gln Leu 
    2210                 2215                 2220             


Ser Leu  Leu Gly Ser Asp Val  Asp Gly Pro Ser Leu  Ala Lys Ala 
    2225                 2230                 2235             


Pro Ile  Ser Ala Pro Phe Val  His Glu Gly Leu Gly  Val Ala Val 
    2240                 2245                 2250             


Gly Gly  Phe Pro Ala Ser Arg  His Gly Ser Pro Ser  Arg Ser Ala 
    2255                 2260                 2265             


Arg Val  Pro Pro Phe Asn Tyr  Val Pro Ser Pro Met  Val Val Ala 
    2270                 2275                 2280             


Ala Xaa  Xaa Asp Ser Ala Ala  Glu Lys Ala Pro Ala  Xaa Ala Ser 
    2285                 2290                 2295             


Ala Xaa  Leu Leu Glu 
    2300             


<210> 2543
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2543
Met Ser Trp Pro Arg Arg Leu Leu Leu Arg Tyr Leu Phe Pro Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Val Lys 
            20          


<210> 2544
<211> 61
<212> PRT
<213> Homo sapiens

<400> 2544
Met Ser Trp Pro Arg Arg Leu Leu Leu Arg Tyr Leu Phe Pro Ala Leu 
1               5                   10                  15      


Leu Leu His Glu Pro Arg Pro Cys Leu His Arg Leu Ser Asp His Leu 
            20                  25                  30          


Ser Val Arg Arg Ala Pro Pro Ser His Pro Ala Pro Lys Gly Arg Pro 
        35                  40                  45              


Asp His Arg Pro Ala Arg Gly Val Gly Glu Pro Ala Leu 
    50                  55                  60      


<210> 2545
<211> 184
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<400> 2545
Met Ser Trp Pro Arg Arg Leu Leu Leu Arg Tyr Leu Phe Pro Ala Leu 
1               5                   10                  15      


Leu Leu His Gly Leu Gly Glu Gly Ser Ala Leu Leu His Pro Asp Ser 
            20                  25                  30          


Arg Ser His Pro Arg Ser Leu Glu Lys Ser Ala Trp Arg Ala Phe Lys 
        35                  40                  45              


Glu Ser Gln Cys His His Met Leu Lys His Leu His Asn Gly Ala Arg 
    50                  55                  60                  


Ile Xaa Val Gln Met Pro Pro Xaa Ile Glu Gly His Trp Val Ser Xaa 
65                  70                  75                  80  


Gly Cys Glu Val Arg Ser Gly Pro Glu Phe Ile Xaa Arg Ser Tyr Arg 
                85                  90                  95      


Phe Tyr His Asn Asn Xaa Phe Lys Ala Tyr Gln Phe Tyr Tyr Gly Ser 
            100                 105                 110         


Asn Arg Cys Xaa Asn Pro Xaa Tyr Xaa Leu Ile Ile Arg Gly Lys Ile 
        115                 120                 125             


Arg Leu Arg Gln Ala Ser Trp Ile Ile Arg Gly Gly Xaa Glu Ala Asp 
    130                 135                 140                 


Tyr Gln Leu His Asn Val Gln Gly His Gly Arg His Arg Val Arg Val 
145                 150                 155                 160 


Gln Ser Glu Ser His Glu Gly His Pro His Gly Cys Gly His Ser Leu 
                165                 170                 175     


Xaa Ala Gln Arg Leu Gln Arg Glu 
            180                 


<210> 2546
<211> 514
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<400> 2546
Met Ser Trp Pro Arg Arg Leu Leu Leu Arg Tyr Leu Phe Pro Ala Leu 
1               5                   10                  15      


Leu Leu His Gly Leu Gly Glu Gly Ser Ala Leu Leu His Pro Asp Ser 
            20                  25                  30          


Arg Ser His Pro Arg Ser Leu Glu Lys Ser Ala Trp Arg Ala Phe Lys 
        35                  40                  45              


Glu Ser Gln Cys His His Met Leu Lys His Leu His Asn Gly Ala Arg 
    50                  55                  60                  


Ile Xaa Val Gln Met Pro Pro Xaa Ile Glu Gly His Trp Val Ser Xaa 
65                  70                  75                  80  


Gly Cys Glu Val Arg Ser Gly Pro Glu Phe Ile Xaa Arg Ser Tyr Arg 
                85                  90                  95      


Phe Tyr His Asn Asn Xaa Phe Lys Ala Tyr Gln Phe Tyr Tyr Gly Ser 
            100                 105                 110         


Asn Arg Cys Xaa Asn Pro Xaa Tyr Xaa Leu Ile Ile Arg Gly Lys Ile 
        115                 120                 125             


Arg Leu Arg Gln Ala Ser Trp Ile Ile Arg Gly Gly Xaa Glu Ala Asp 
    130                 135                 140                 


Tyr Gln Leu His Asn Val Gln Val Ile Cys His Xaa Glu Ala Val Ala 
145                 150                 155                 160 


Glu Lys Leu Gly Gln Gln Val Asn Arg Xaa Cys Pro Gly Phe Leu Ala 
                165                 170                 175     


Asp Gly Gly Pro Trp Val Gln Asp Val Ala Tyr Asp Leu Trp Arg Glu 
            180                 185                 190         


Glu Asn Gly Cys Glu Cys Xaa Lys Ala Val Asn Phe Ala Met His Glu 
        195                 200                 205             


Leu Gln Leu Ile Arg Val Glu Lys Gln Tyr Leu His His Asn Leu Asp 
    210                 215                 220                 


His Leu Val Glu Glu Leu Phe Leu Gly Asp Ile His Xaa Asp Ala Xaa 
225                 230                 235                 240 


Gln Arg Met Phe Tyr Arg Pro Ser Ser Tyr Gln Pro Pro Leu Gln Asn 
                245                 250                 255     


Ala Lys Asn His Asp His Ala Cys Ile Ala Cys Arg Ile Ile Tyr Arg 
            260                 265                 270         


Ser Asp Glu His His Pro Pro Ile Leu Pro Pro Lys Ala Asp Leu Xaa 
        275                 280                 285             


Ile Gly Leu His Gly Glu Trp Val Ser Gln Arg Cys Glu Val Arg Pro 
    290                 295                 300                 


Glu Val Leu Phe Leu Xaa Arg His Phe Ile Phe His Asp Asn Asn Asn 
305                 310                 315                 320 


Xaa Trp Glu Gly His Tyr Tyr His Tyr Ser Asp Pro Val Cys Lys His 
                325                 330                 335     


Pro Xaa Phe Ser Ile Tyr Ala Arg Gly Arg Tyr Ser Arg Gly Val Leu 
            340                 345                 350         


Ser Ser Arg Val Met Gly Gly Xaa Glu Phe Val Phe Lys Val Asn His 
        355                 360                 365             


Met Lys Val Xaa Pro Met Asp Ala Ala Xaa Ala Ser Leu Leu Asn Val 
    370                 375                 380                 


Phe Asn Gly Asn Glu Cys Gly Ala Glu Gly Ser Trp Gln Val Gly Ile 
385                 390                 395                 400 


Gln Gln Asp Val Xaa His Xaa Asn Gly Cys Val Ala Leu Gly Ile Lys 
                405                 410                 415     


Leu Pro His Xaa Glu Tyr Glu Ile Phe Lys Met Glu Gln Asp Ala Arg 
            420                 425                 430         


Gly Arg Tyr Leu Leu Phe Asn Gly Gln Arg Pro Ser Asp Gly Ser Ser 
        435                 440                 445             


Pro Asp Arg Pro Glu Lys Arg Ala Xaa Ser Tyr Gln Met Pro Leu Val 
    450                 455                 460                 


Gln Cys Ala Ser Ser Ser Pro Arg Ala Glu Asp Leu Ala Glu Asp Ser 
465                 470                 475                 480 


Gly Ser Ser Leu Tyr Gly Arg Ala Pro Gly Arg His Xaa Trp Ser Leu 
                485                 490                 495     


Leu Leu Ala Ala Leu Ala Cys Leu Val Pro Leu Leu His Trp Asn Ile 
            500                 505                 510         


Arg Arg 
        


<210> 2547
<211> 94
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<400> 2547
Pro Glu Asp Val Leu Pro Ala Leu Gln Leu Pro Ala Pro Ser Ala Glu 
1               5                   10                  15      


Cys Gln Val Glu Met Gly Phe His His Val Gly Gln Asp Gly Leu Gln 
            20                  25                  30          


Leu Pro Xaa Ser Ser Asp Pro Pro Ala Leu Ala Ser Gln Ser Ala Gly 
        35                  40                  45              


Ile Xaa Gly Val Ser His Arg Pro Pro Gly Arg His Leu Ser Asn Asp 
    50                  55                  60                  


Leu Arg Xaa Xaa Xaa Met Pro Ala Ser Pro Val Gly Ser Ser Ile Gly 
65                  70                  75                  80  


Gln Xaa Ser Xaa Xaa Leu Pro Ser Cys Pro Gln Arg Gln Xaa 
                85                  90                  


<210> 2548
<211> 227
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<400> 2548
Xaa Asp Val Ala Tyr Asp Leu Trp Arg Glu Glu Asn Gly Cys Glu Cys 
1               5                   10                  15      


Xaa Lys Ala Val Asn Phe Ala Met His Glu Leu Gln Leu Ile Arg Val 
            20                  25                  30          


Glu Lys Gln Tyr Leu His His Asn Leu Asp His Leu Val Glu Glu Leu 
        35                  40                  45              


Phe Leu Gly Asp Ile His Xaa Asp Ala Xaa Gln Arg Met Phe Tyr Arg 
    50                  55                  60                  


Pro Ser Ser Tyr Gln Pro Pro Leu Gln Asn Ala Lys Cys Ala Ala Glu 
65                  70                  75                  80  


Ser Ser Gly Ser Phe Gln Ile Leu Pro Gln Asp Ser Ser Glu Lys Glu 
                85                  90                  95      


Gln Asn Gly Leu Ser His Trp Cys Leu Ser Arg Pro Gly His Gln Lys 
            100                 105                 110         


Asp Trp Ala Leu Cys Ala His Ala Gly Pro Ala Xaa Ala Gly Cys Pro 
        115                 120                 125             


Ser Cys Leu Trp Pro Pro Ala Glu Xaa Gly Arg Lys Ala Gly Arg Xaa 
    130                 135                 140                 


Ser Ser Lys Xaa Val His Ala Cys Pro Gly Glu Ala Gly Xaa Ser Ser 
145                 150                 155                 160 


Phe Glu Leu Phe Tyr Phe Pro Asn Cys Trp Ser Ile Glu Xaa Lys Leu 
                165                 170                 175     


Lys Ile Ser Leu Asn Ala Lys Leu Ser Phe Lys Pro Arg Ala Ser Ala 
            180                 185                 190         


Pro Leu Glu Xaa Gly His Arg Val Lys Ile Glu Xaa Leu Ser Gln Leu 
        195                 200                 205             


Val Phe Leu Ser Phe Ile Gln Leu Cys Cys Glu Val Gln Ser Pro Leu 
    210                 215                 220                 


Ala Asn Lys 
225         


<210> 2549
<211> 54
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<400> 2549
Met Arg Phe Gln Gln Phe Leu Phe Ala Phe Phe Ile Phe Ile Met Ser 
1               5                   10                  15      


Leu Leu Leu Ile Ser Gly Gln Arg Pro Val Asn Leu Xaa Met Arg Arg 
            20                  25                  30          


Lys Leu Arg Lys His Asn Cys Leu Gln Arg Arg Cys Met Pro Leu His 
        35                  40                  45              


Ser Arg Val Pro Phe Pro 
    50                  


<210> 2550
<211> 518
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<400> 2550
Met Leu Arg Val Val Ser Trp Asn Ile Asn Gly Ile Arg Arg Pro Leu 
1               5                   10                  15      


Gln Gly Val Ala Asn Gln Glu Pro Ser Asn Cys Ala Ala Val Ala Val 
            20                  25                  30          


Gly Arg Ile Leu Asp Glu Leu Asp Ala Asp Ile Val Cys Leu Gln Glu 
        35                  40                  45              


Xaa Lys Val Xaa Arg Asp Ala Leu Xaa Glu Pro Leu Ala Ile Val Glu 
    50                  55                  60                  


Gly Tyr Asn Ser Tyr Phe Ser Phe Ser Arg Asn Arg Ser Gly Tyr Ser 
65                  70                  75                  80  


Gly Val Ala Xaa Phe Cys Lys Asp Asn Ala Xaa Pro Val Ala Ala Glu 
                85                  90                  95      


Glu Gly Leu Ser Gly Leu Phe Ala Xaa Gln Asn Gly Asp Val Gly Cys 
            100                 105                 110         


Tyr Gly Asn Met Asp Glu Phe Xaa Gln Glu Glu Leu Arg Ala Leu Asp 
        115                 120                 125             


Ser Glu Gly Arg Ala Leu Leu Xaa Gln His Lys Ile Arg Xaa Trp Glu 
    130                 135                 140                 


Gly Lys Glu Lys Xaa Leu Xaa Leu Ile Asn Val Tyr Cys Pro His Ala 
145                 150                 155                 160 


Asp Pro Gly Arg Pro Glu Arg Leu Val Phe Lys Met Arg Phe Tyr Arg 
                165                 170                 175     


Leu Leu Gln Ile Arg Ala Glu Ala Leu Leu Ala Ala Gly Ser His Val 
            180                 185                 190         


Ile Ile Leu Gly Asp Leu Asn Xaa Ala His Arg Pro Ile Asp His Trp 
        195                 200                 205             


Asp Ala Val Asn Leu Glu Cys Phe Glu Glu Asp Pro Gly Arg Lys Trp 
    210                 215                 220                 


Met Asp Ser Leu Leu Ser Asn Leu Gly Cys Gln Ser Ala Ser His Val 
225                 230                 235                 240 


Gly Pro Phe Ile Asp Ser Tyr Arg Cys Phe Gln Pro Lys Gln Glu Gly 
                245                 250                 255     


Ala Phe Xaa Cys Trp Ser Ala Val Xaa Gly Ala Arg His Leu Asn Tyr 
            260                 265                 270         


Gly Ser Arg Leu Asp Tyr Val Leu Gly Asp Arg Xaa Leu Val Ile Asp 
        275                 280                 285             


Xaa Phe Gln Ala Ser Phe Leu Leu Pro Glu Val Met Gly Ser Asp His 
    290                 295                 300                 


Cys Pro Val Gly Ala Val Leu Ser Val Ser Ser Val Pro Ala Lys Gln 
305                 310                 315                 320 


Cys Pro Pro Leu Cys Xaa Arg Phe Leu Pro Glu Phe Ala Gly Xaa Gln 
                325                 330                 335     


Leu Lys Ile Leu Arg Phe Leu Val Pro Leu Glu Gln Ser Pro Val Leu 
            340                 345                 350         


Glu Gln Ser Xaa Leu Gln His Asn Asn Gln Xaa Arg Val Gln Xaa Cys 
        355                 360                 365             


Gln Asn Lys Ala Gln Val Arg Ser Xaa Arg Pro Gln Pro Ser Gln Val 
    370                 375                 380                 


Gly Ser Ser Arg Gly Gln Lys Asn Leu Lys Ser Tyr Phe Gln Pro Ser 
385                 390                 395                 400 


Pro Ser Cys Pro Gln Ala Ser Pro Asp Ile Glu Leu Pro Ser Leu Pro 
                405                 410                 415     


Leu Met Ser Ala Leu Met Xaa Pro Lys Xaa Pro Glu Glu Lys Ala Val 
            420                 425                 430         


Ala Lys Val Val Lys Gly Gln Ala Lys Xaa Ser Glu Ala Lys Asp Glu 
        435                 440                 445             


Lys Glu Leu Arg Xaa Ser Phe Trp Lys Ser Val Leu Ala Gly Pro Leu 
    450                 455                 460                 


Arg Xaa Pro Leu Cys Gly Gly His Arg Glu Pro Cys Val Met Arg Xaa 
465                 470                 475                 480 


Val Lys Lys Pro Gly Pro Asn Leu Gly Arg Arg Phe Tyr Met Cys Ala 
                485                 490                 495     


Arg Pro Arg Gly Pro Pro Xaa Asp Pro Ser Ser Arg Cys Asn Phe Phe 
            500                 505                 510         


Leu Trp Ser Arg Pro Ser 
        515             


<210> 2551
<211> 247
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<400> 2551
Met Gly Ala Ala Val Phe Phe Gly Cys Xaa Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Xaa Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 
        35                  40                  45              


Ala Ser Val Val Trp Phe Ile Leu Val His Val Xaa Asp Arg Ser Asp 
    50                  55                  60                  


Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Asp Glu Gly Leu Ala Ser Leu Ser Glu Asp Gly Arg Ser Pro Ile 
            100                 105                 110         


Ser Ile Arg Gln Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile 
        115                 120                 125             


Ser Gly Val Phe Ser Val Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro 
    130                 135                 140                 


Gly Val Val Gly Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Xaa Ser 
145                 150                 155                 160 


Ala Phe Leu Xaa Ala Ala Ile Ile Leu Leu His Xaa Phe Trp Gly Val 
                165                 170                 175     


Val Phe Phe Asp Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu 
            180                 185                 190         


Val Val Gly Ser His Leu Leu Xaa Ser Gly Leu Xaa Phe Leu Asn Pro 
        195                 200                 205             


Trp Tyr Glu Ala Ser Leu Leu Pro Ile Tyr Ala Val Xaa Val Ser Met 
    210                 215                 220                 


Gly Leu Trp Ala Phe Ile Xaa Ala Gly Gly Ser Leu Arg Ser Ile Gln 
225                 230                 235                 240 


Arg Ser Leu Leu Cys Lys Asp 
                245         


<210> 2552
<211> 265
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<400> 2552
Met Gly Ala Ala Val Phe Phe Gly Cys Xaa Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Xaa Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 
        35                  40                  45              


Ala Ser Val Val Trp Phe Ile Leu Val His Val Xaa Asp Arg Ser Asp 
    50                  55                  60                  


Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Asp Glu Gly Leu Ala Ser Leu Ser Glu Asp Gly Arg Ser Pro Ile 
            100                 105                 110         


Ser Ile Arg Gln Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile 
        115                 120                 125             


Ser Gly Val Phe Ser Val Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro 
    130                 135                 140                 


Gly Val Val Gly Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Xaa Ser 
145                 150                 155                 160 


Ala Phe Leu Xaa Ala Ala Ile Ile Leu Leu His Xaa Phe Trp Gly Val 
                165                 170                 175     


Val Phe Phe Asp Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu 
            180                 185                 190         


Val Val Gly Ser His Leu Leu Xaa Ser Gly Leu Xaa Phe Leu Asn Pro 
        195                 200                 205             


Trp Tyr Glu Ala Ser Leu Leu Pro Ile Tyr Ala Val Xaa Val Ser Met 
    210                 215                 220                 


Gly Leu Trp Ala Phe Ile Xaa Ala Gly Gly Ser Leu Arg Ser Ile Gln 
225                 230                 235                 240 


Arg Ser Leu Leu Cys Arg Arg Gln Glu Asp Ser Arg Val Met Val Tyr 
                245                 250                 255     


Ser Ala Leu Arg Ile Pro Pro Glu Asp 
            260                 265 


<210> 2553
<211> 150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<400> 2553
Met Gly Ala Ala Val Phe Phe Gly Cys Xaa Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Xaa Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Lys Ala Asp Glu Gly Leu Ala Ser Leu Ser 
        35                  40                  45              


Glu Asp Gly Arg Ser Pro Ile Ser Ile Arg Gln Met Ala Tyr Val Ser 
    50                  55                  60                  


Gly Leu Ser Phe Gly Ile Ile Ser Gly Val Phe Ser Val Ile Asn Ile 
65                  70                  75                  80  


Leu Ala Asp Ala Leu Gly Pro Gly Val Val Gly Ile His Gly Asp Ser 
                85                  90                  95      


Pro Tyr Tyr Phe Leu Xaa Ser Ala Phe Leu Xaa Ala Ala Ile Ile Leu 
            100                 105                 110         


Leu His Xaa Phe Trp Gly Val Val Phe Phe Asp Ala Cys Glu Arg Arg 
        115                 120                 125             


Arg Tyr Trp Ala Leu Gly Leu Val Val Gly Ser His Leu Leu Xaa Ser 
    130                 135                 140                 


Gly Leu Xaa Phe Leu Asn 
145                 150 


<210> 2554
<211> 195
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<400> 2554
Met Gly Ala Ala Val Phe Phe Gly Cys Xaa Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Xaa Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Arg Cys Ser Ala Leu Pro Xaa Xaa Ser Cys 
        35                  40                  45              


Leu Ile Ser Gly Leu Ser Phe Gly Ile Ile Ser Gly Val Phe Ser Val 
    50                  55                  60                  


Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro Gly Val Val Gly Ile His 
65                  70                  75                  80  


Gly Asp Ser Pro Tyr Tyr Phe Leu Xaa Ser Ala Phe Leu Xaa Ala Ala 
                85                  90                  95      


Ile Ile Leu Leu His Xaa Phe Trp Gly Val Val Phe Phe Asp Ala Cys 
            100                 105                 110         


Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu Val Val Gly Ser His Leu 
        115                 120                 125             


Leu Xaa Ser Gly Leu Xaa Phe Leu Asn Pro Trp Tyr Glu Ala Ser Leu 
    130                 135                 140                 


Leu Pro Ile Tyr Ala Val Xaa Val Ser Met Gly Leu Trp Ala Phe Ile 
145                 150                 155                 160 


Xaa Ala Gly Gly Ser Leu Arg Ser Ile Gln Arg Ser Leu Leu Cys Arg 
                165                 170                 175     


Arg Gln Glu Asp Ser Arg Val Met Val Tyr Ser Ala Leu Arg Ile Pro 
            180                 185                 190         


Pro Glu Asp 
        195 


<210> 2555
<211> 19
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<400> 2555
Leu Tyr Val Phe Xaa Ile Ala Xaa Glu Pro Leu Arg Ile Ile Phe Leu 
1               5                   10                  15      


Ile Ala Gly 
            


<210> 2556
<211> 189
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<400> 2556
Met Ala Arg Val Ile Ile Asp Asn Lys Asp Gly Pro Xaa Gln Lys Tyr 
1               5                   10                  15      


Leu Leu Ile Phe Gly Ala Phe Val Ser Val Tyr Ile Gln Glu Met Phe 
            20                  25                  30          


Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys Ala Ser Glu Gly Leu Lys 
        35                  40                  45              


Ser Ile Asn Pro Gly Glu Xaa Ala Pro Ser Met Arg Leu Leu Ala Tyr 
    50                  55                  60                  


Val Ser Gly Leu Gly Phe Gly Ile Met Ser Gly Val Phe Ser Phe Val 
65                  70                  75                  80  


Asn Xaa Leu Ser Asp Ser Leu Gly Pro Gly Xaa Val Gly Ile His Gly 
                85                  90                  95      


Asp Ser Pro Gln Phe Phe Leu Tyr Ser Ala Phe Met Xaa Leu Val Ile 
            100                 105                 110         


Ile Leu Leu His Val Phe Trp Gly Ile Val Phe Phe Asp Gly Cys Glu 
        115                 120                 125             


Lys Lys Lys Trp Gly Ile Leu Leu Ile Val Leu Leu Xaa His Leu Leu 
    130                 135                 140                 


Val Ser Ala Gln Xaa Phe Ile Ser Ser Tyr Tyr Gly Ile Asn Leu Ala 
145                 150                 155                 160 


Ser Ala Phe Ile Ile Leu Val Leu Met Gly Xaa Trp Ala Phe Leu Ala 
                165                 170                 175     


Ala Gly Gly Ser Cys Arg Ser Leu Lys Leu Cys Leu Leu 
            180                 185                 


<210> 2557
<211> 216
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<400> 2557
Met Xaa Ala Ala Val Phe Phe Gly Cys Ala Phe Ile Ala Phe Gly Pro 
1               5                   10                  15      


Ala Leu Ala Leu Tyr Val Phe Xaa Ile Ala Xaa Glu Pro Leu Arg Ile 
            20                  25                  30          


Ile Phe Leu Ile Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Ile 
        35                  40                  45              


Ser Ser Leu Val Trp Phe Met Ala Arg Val Ile Ile Asp Asn Lys Asp 
    50                  55                  60                  


Gly Pro Xaa Gln Lys Tyr Leu Leu Ile Phe Gly Ala Phe Val Ser Val 
65                  70                  75                  80  


Tyr Ile Gln Glu Met Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Ser Glu Gly Leu Lys Ser Ile Asn Pro Gly Glu Xaa Ala Pro Ser 
            100                 105                 110         


Met Arg Leu Leu Ala Tyr Ala Phe Met Xaa Leu Val Ile Ile Leu Leu 
        115                 120                 125             


His Val Phe Trp Gly Ile Val Phe Phe Asp Gly Cys Glu Lys Lys Lys 
    130                 135                 140                 


Trp Gly Ile Leu Leu Ile Val Leu Leu Xaa His Leu Leu Val Ser Ala 
145                 150                 155                 160 


Gln Xaa Phe Ile Ser Ser Tyr Tyr Gly Ile Asn Leu Ala Ser Ala Phe 
                165                 170                 175     


Ile Ile Leu Val Leu Met Gly Xaa Trp Ala Phe Leu Ala Ala Gly Gly 
            180                 185                 190         


Ser Cys Arg Ser Leu Lys Leu Cys Leu Leu Cys Gln Asp Lys Asn Phe 
        195                 200                 205             


Leu Leu Tyr Asn Gln Arg Ser Arg 
    210                 215     


<210> 2558
<211> 257
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<400> 2558
Met Xaa Ala Ala Val Phe Phe Gly Cys Ala Phe Ile Ala Phe Gly Pro 
1               5                   10                  15      


Ala Leu Ala Leu Tyr Val Phe Xaa Ile Ala Xaa Glu Pro Leu Arg Ile 
            20                  25                  30          


Ile Phe Leu Ile Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Ile 
        35                  40                  45              


Ser Ser Leu Val Trp Phe Met Ala Arg Val Ile Ile Asp Asn Lys Asp 
    50                  55                  60                  


Gly Pro Xaa Gln Lys Tyr Leu Leu Ile Phe Gly Ala Phe Val Ser Val 
65                  70                  75                  80  


Tyr Ile Gln Glu Met Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Ser Glu Gly Leu Lys Ser Ile Asn Pro Gly Glu Xaa Ala Pro Ser 
            100                 105                 110         


Met Arg Leu Leu Ala Tyr Val Ser Gly Leu Gly Phe Gly Ile Met Ser 
        115                 120                 125             


Gly Val Phe Ser Phe Val Asn Xaa Leu Ser Asp Ser Leu Gly Pro Gly 
    130                 135                 140                 


Xaa Val Gly Ile His Gly Asp Ser Pro Gln Phe Phe Leu Tyr Ser Ala 
145                 150                 155                 160 


Phe Met Xaa Leu Val Ile Ile Leu Leu His Val Phe Trp Gly Ile Val 
                165                 170                 175     


Phe Phe Asp Gly Cys Glu Lys Lys Lys Trp Gly Ile Leu Leu Ile Val 
            180                 185                 190         


Leu Leu Xaa His Leu Leu Val Ser Ala Gln Xaa Phe Ile Ser Ser Tyr 
        195                 200                 205             


Tyr Gly Ile Asn Leu Ala Ser Ala Phe Ile Ile Leu Val Leu Met Gly 
    210                 215                 220                 


Xaa Trp Ala Phe Leu Ala Ala Gly Gly Ser Cys Arg Ser Leu Lys Leu 
225                 230                 235                 240 


Cys Leu Leu Cys Gln Asp Lys Asn Phe Leu Leu Tyr Asn Gln Arg Ser 
                245                 250                 255     


Arg 
    


<210> 2559
<211> 222
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<400> 2559
Met Xaa Ala Ala Val Phe Phe Gly Cys Ala Phe Ile Ala Phe Gly Pro 
1               5                   10                  15      


Ala Leu Ala Leu Tyr Val Phe Xaa Ile Ala Xaa Glu Pro Leu Arg Ile 
            20                  25                  30          


Ile Phe Leu Ile Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Ile 
        35                  40                  45              


Ser Ser Leu Val Trp Phe Met Ala Arg Val Ile Ile Asp Asn Lys Asp 
    50                  55                  60                  


Gly Pro Xaa Gln Lys Tyr Leu Leu Ile Phe Gly Ala Phe Val Ser Val 
65                  70                  75                  80  


Tyr Ile Gln Glu Met Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Ser Glu Gly Leu Lys Ser Ile Asn Pro Gly Glu Xaa Ala Pro Ser 
            100                 105                 110         


Met Arg Leu Leu Ala Tyr Val Ser Gly Leu Gly Phe Gly Ile Met Ser 
        115                 120                 125             


Gly Val Phe Ser Phe Val Asn Xaa Leu Ser Asp Ser Leu Gly Pro Gly 
    130                 135                 140                 


Xaa Val Gly Ile His Gly Asp Ser Pro Gln Phe Phe Leu Tyr Ser Asp 
145                 150                 155                 160 


Leu His Lys Phe Leu Leu Trp Asn Lys Pro Gly Val Ser Ile Tyr Asn 
                165                 170                 175     


Pro Gly Ala His Gly His Leu Gly Ile Leu Ser Cys Gly Arg Gln Leu 
            180                 185                 190         


Pro Lys Pro Glu Xaa Leu Pro Ala Leu Pro Arg Gln Glu Leu Ser Ser 
        195                 200                 205             


Leu Gln Pro Ala Leu Gln Ile Xaa Ser Gly Asn Gln His Phe 
    210                 215                 220         


<210> 2560
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<400> 2560
Met Xaa Ala Ala Val Phe Phe Gly Cys Ala Phe Ile Ala Phe Gly Pro 
1               5                   10                  15      


Ala Leu Ala Leu Tyr Val Phe Xaa Ile Ala Xaa Glu Pro Leu Arg Ile 
            20                  25                  30          


Ile Phe Leu Ile Ala Gly Arg Arg Val Glu Xaa Cys Lys Asn Xaa Glu 
        35                  40                  45              


Ala Pro Asp Cys Ala Ser Pro Ser Gly Ser Leu Ser Phe Leu Leu Val 
    50                  55                  60                  


Gly Val Ser Xaa Asp Phe Val Pro Cys Leu Val His Gly Lys Ser His 
65                  70                  75                  80  


Tyr 
    


<210> 2561
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<400> 2561
Met Asn Leu Arg Leu Cys Val Gln Ala Leu Leu Leu Leu Trp Leu Ser 
1               5                   10                  15      


Leu Xaa Ala Val Cys Gly Gly Ser Leu Met Pro Leu Pro Asp Gly Asn 
            20                  25                  30          


Gly Leu Glu Asp Gly Asn Val Arg His Leu Val Gln Pro Arg Gly Ser 
        35                  40                  45              


Arg Asn Gly Pro Gly Pro Trp Gln Gly Gly Arg Arg Lys Phe Arg Arg 
    50                  55                  60                  


Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
65                  70                  75          


<210> 2562
<211> 380
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<400> 2562
Met Glu Glu Gly Gly Asp Phe Asp Asn Tyr Tyr Gly Ala Asp Asn Gln 
1               5                   10                  15      


Ser Glu Cys Glu Tyr Xaa Asp Trp Lys Ser Ser Gly Ala Leu Ile Pro 
            20                  25                  30          


Ala Ile Tyr Met Leu Val Phe Leu Leu Gly Xaa Xaa Gly Asn Gly Leu 
        35                  40                  45              


Val Leu Trp Xaa Val Phe Arg Ser Ser Arg Glu Lys Arg Arg Ser Ala 
    50                  55                  60                  


Asp Ile Phe Ile Ala Ser Leu Ala Val Ala Asp Leu Xaa Phe Val Val 
65                  70                  75                  80  


Xaa Leu Pro Leu Trp Ala Xaa Tyr Xaa Tyr Arg Asp Tyr Asp Trp Pro 
                85                  90                  95      


Phe Gly Xaa Phe Phe Cys Lys Leu Ser Ser Tyr Leu Ile Phe Val Asn 
            100                 105                 110         


Met Tyr Ala Ser Val Phe Cys Leu Xaa Gly Leu Ser Phe Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Arg Pro Val Ala Asn Ala Arg Leu Arg Leu Arg Val 
    130                 135                 140                 


Ser Gly Ala Val Ala Xaa Ala Val Leu Trp Val Leu Ala Ala Leu Leu 
145                 150                 155                 160 


Ala Met Pro Val Met Val Leu Arg Xaa Xaa Gly Asp Leu Glu Asn Xaa 
                165                 170                 175     


Xaa Lys Val Gln Cys Tyr Met Asp Tyr Ser Met Val Ala Xaa Val Ser 
            180                 185                 190         


Ser Glu Trp Ala Trp Glu Val Gly Leu Gly Val Ser Ser Xaa Xaa Val 
        195                 200                 205             


Gly Phe Val Val Pro Phe Xaa Ile Met Leu Xaa Cys Tyr Phe Phe Ile 
    210                 215                 220                 


Ala Gln Xaa Ile Ala Gly His Phe Arg Lys Glu Arg Ile Glu Gly Leu 
225                 230                 235                 240 


Arg Lys Arg Arg Arg Leu Leu Ser Ile Ile Val Val Leu Val Val Xaa 
                245                 250                 255     


Phe Ala Leu Cys Trp Met Pro Tyr His Leu Val Lys Xaa Leu Tyr Met 
            260                 265                 270         


Leu Gly Ser Leu Leu His Trp Pro Cys Asp Phe Asp Leu Phe Leu Met 
        275                 280                 285             


Asn Ile Phe Pro Tyr Cys Xaa Cys Ile Ser Tyr Val Asn Ser Cys Leu 
    290                 295                 300                 


Asn Pro Phe Leu Tyr Ala Phe Phe Asp Pro Arg Phe Arg Gln Ala Cys 
305                 310                 315                 320 


Xaa Ser Met Leu Cys Cys Gly Gln Ser Arg Cys Ala Gly Xaa Ser His 
                325                 330                 335     


Ser Ser Ser Gly Glu Lys Ser Ala Ser Tyr Ser Ser Gly His Ser Gln 
            340                 345                 350         


Gly Pro Gly Pro Asn Met Gly Lys Gly Gly Glu Gln Met His Glu Lys 
        355                 360                 365             


Ser Ile Pro Tyr Ser Gln Glu Xaa Leu Val Val Asp 
    370                 375                 380 


<210> 2563
<211> 644
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<400> 2563
Met Glu Ala Val Cys Gly Ala Trp Gly Arg Gly Leu Val Leu Gly Val 
1               5                   10                  15      


Ser Val Leu Gly Ser Lys Glu Pro Gly Asp Pro His Ala Asn Ala Pro 
            20                  25                  30          


Arg Ala Leu Xaa Val Leu Ser Xaa Ser Ile Gln Ala Pro Gly Ser Ala 
        35                  40                  45              


Gln Val Ala Gly Leu Cys Gly Arg Leu Xaa Leu His Arg Asp Leu Arg 
    50                  55                  60                  


Xaa Gly Arg Trp Glu Pro Asp Pro Gln Arg Ser Arg Arg Cys Leu Arg 
65                  70                  75                  80  


Asp Pro Gln Arg Val Leu Glu Tyr Cys Arg Gln Met Tyr Pro Glu Leu 
                85                  90                  95      


Gln Ile Ala Arg Val Glu Gln Ala Xaa Gln Ala Ile Pro Met Glu Arg 
            100                 105                 110         


Trp Cys Gly Gly Ser Arg Ser Gly Ser Cys Ala His Pro His His Gln 
        115                 120                 125             


Val Val Pro Phe Arg Cys Leu Pro Gly Glu Phe Val Ser Glu Ala Leu 
    130                 135                 140                 


Leu Val Pro Glu Gly Cys Arg Phe Leu His Gln Glu Arg Met Asp Gln 
145                 150                 155                 160 


Cys Glu Ser Ser Xaa Arg Arg His Gln Glu Ala Gln Glu Ala Cys Ser 
                165                 170                 175     


Ser Gln Gly Leu Ile Leu His Gly Ser Gly Met Leu Leu Pro Cys Gly 
            180                 185                 190         


Ser Asp Arg Phe Arg Gly Val Glu Tyr Val Cys Cys Pro Pro Pro Gly 
        195                 200                 205             


Xaa Pro Asp Pro Ser Gly Xaa Ala Val Gly Asp Pro Ser Xaa Arg Ser 
    210                 215                 220                 


Trp Pro Pro Gly Ser Arg Val Glu Gly Ala Glu Asp Glu Glu Glu Glu 
225                 230                 235                 240 


Glu Ser Phe Pro Gln Pro Val Asp Asp Tyr Phe Val Glu Pro Pro Gln 
                245                 250                 255     


Ala Glu Glu Glu Glu Glu Xaa Val Pro Pro Pro Ser Ser His Xaa Leu 
            260                 265                 270         


Ala Val Val Gly Lys Val Xaa Pro Xaa Pro Arg Pro Xaa Asp Gly Val 
        275                 280                 285             


Asp Ile Tyr Phe Gly Met Pro Gly Glu Ile Ser Glu His Glu Gly Phe 
    290                 295                 300                 


Leu Arg Ala Lys Met Asp Leu Glu Glu Arg Arg Met Arg Gln Ile Asn 
305                 310                 315                 320 


Glu Val Met Arg Glu Trp Ala Met Ala Asp Asn Gln Ser Lys Asn Leu 
                325                 330                 335     


Pro Lys Ala Asp Arg Gln Ala Leu Asn Glu His Phe Gln Ser Ile Leu 
            340                 345                 350         


Gln Xaa Leu Glu Glu Gln Val Ser Gly Glu Arg Gln Arg Leu Val Glu 
        355                 360                 365             


Xaa His Ala Xaa Arg Val Ile Ala Leu Ile Asn Asp Gln Arg Arg Ala 
    370                 375                 380                 


Ala Leu Glu Gly Phe Leu Ala Ala Leu Gln Ala Asp Pro Pro Gln Ala 
385                 390                 395                 400 


Glu Arg Val Leu Leu Ala Leu Arg Arg Tyr Leu Arg Ala Glu Gln Lys 
                405                 410                 415     


Glu Gln Arg His Xaa Leu Arg His Tyr Gln His Val Ala Ala Val Asp 
            420                 425                 430         


Pro Glu Lys Ala Gln Gln Met Arg Phe Gln Val His Xaa His Leu Gln 
        435                 440                 445             


Val Ile Glu Glu Arg Val Asn Gln Ser Leu Gly Leu Leu Asp Gln Asn 
    450                 455                 460                 


Pro His Leu Ala Gln Glu Leu Arg Pro Gln Ile Gln Glu Leu Leu His 
465                 470                 475                 480 


Ser Glu His Leu Gly Pro Ser Glu Leu Glu Ala Pro Ala Pro Gly Gly 
                485                 490                 495     


Ser Ser Glu Asp Lys Gly Gly Leu Gln Pro Pro Asp Ser Lys Asp Asp 
            500                 505                 510         


Xaa Pro Met Xaa Leu Pro Lys Gly Ser Xaa Glu Gln Asp Ala Ala Ser 
        515                 520                 525             


Pro Glu Lys Glu Lys Met Asn Pro Leu Glu Gln Tyr Glu Arg Lys Val 
    530                 535                 540                 


Asn Ala Ser Val Pro Arg Gly Phe Pro Phe His Ser Ser Glu Ile Gln 
545                 550                 555                 560 


Arg Asp Glu Leu Ala Pro Ala Gly Xaa Gly Val Ser Arg Glu Ala Val 
                565                 570                 575     


Ser Gly Leu Leu Ile Met Gly Ala Gly Gly Gly Ser Leu Ile Val Leu 
            580                 585                 590         


Ser Met Leu Leu Leu Arg Arg Lys Lys Pro Tyr Gly Ala Ile Ser His 
        595                 600                 605             


Gly Val Val Glu Val Asp Pro Met Leu Xaa Leu Glu Glu Gln Gln Leu 
    610                 615                 620                 


Arg Glu Leu Gln Arg His Gly Tyr Glu Asn Pro Xaa Tyr Arg Phe Leu 
625                 630                 635                 640 


Glu Glu Arg Pro 
                


<210> 2564
<211> 651
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<400> 2564
Met Gly Pro Ala Ser Pro Ala Ala Arg Gly Leu Ser Arg Arg Pro Gly 
1               5                   10                  15      


Gln Pro Pro Leu Pro Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Arg 
            20                  25                  30          


Ala Gln Pro Ala Ile Gly Ser Leu Ala Gly Gly Ser Pro Gly Ala Ala 
        35                  40                  45              


Glu Ala Pro Gly Ser Ala Gln Val Ala Gly Leu Cys Gly Arg Leu Xaa 
    50                  55                  60                  


Leu His Arg Asp Leu Arg Xaa Gly Arg Trp Glu Pro Asp Pro Gln Arg 
65                  70                  75                  80  


Ser Arg Arg Cys Leu Arg Asp Pro Gln Arg Val Leu Glu Tyr Cys Arg 
                85                  90                  95      


Gln Met Tyr Pro Glu Leu Gln Ile Ala Arg Val Glu Gln Ala Xaa Gln 
            100                 105                 110         


Ala Ile Pro Met Glu Arg Trp Cys Gly Gly Ser Arg Ser Gly Ser Cys 
        115                 120                 125             


Ala His Pro His His Gln Val Val Pro Phe Arg Cys Leu Pro Gly Glu 
    130                 135                 140                 


Phe Val Ser Glu Ala Leu Leu Val Pro Glu Gly Cys Arg Phe Leu His 
145                 150                 155                 160 


Gln Glu Arg Met Asp Gln Cys Glu Ser Ser Xaa Arg Arg His Gln Glu 
                165                 170                 175     


Ala Gln Glu Ala Cys Ser Ser Gln Gly Leu Ile Leu His Gly Ser Gly 
            180                 185                 190         


Met Leu Leu Pro Cys Gly Ser Asp Arg Phe Arg Gly Val Glu Tyr Val 
        195                 200                 205             


Cys Cys Pro Pro Pro Gly Xaa Pro Asp Pro Ser Gly Xaa Ala Val Gly 
    210                 215                 220                 


Asp Pro Ser Xaa Arg Ser Trp Pro Pro Gly Ser Arg Val Glu Gly Ala 
225                 230                 235                 240 


Glu Asp Glu Glu Glu Glu Glu Ser Phe Pro Gln Pro Val Asp Asp Tyr 
                245                 250                 255     


Phe Val Glu Pro Pro Gln Ala Glu Glu Glu Glu Glu Xaa Val Pro Pro 
            260                 265                 270         


Pro Ser Ser His Xaa Leu Ala Val Val Gly Lys Val Xaa Pro Xaa Pro 
        275                 280                 285             


Arg Pro Xaa Asp Gly Val Asp Ile Tyr Phe Gly Met Pro Gly Glu Ile 
    290                 295                 300                 


Ser Glu His Glu Gly Phe Leu Arg Ala Lys Met Asp Leu Glu Glu Arg 
305                 310                 315                 320 


Arg Met Arg Gln Ile Asn Glu Val Met Arg Glu Trp Ala Met Ala Asp 
                325                 330                 335     


Asn Gln Ser Lys Asn Leu Pro Lys Ala Asp Arg Gln Ala Leu Asn Glu 
            340                 345                 350         


His Phe Gln Ser Ile Leu Gln Xaa Leu Glu Glu Gln Val Ser Gly Glu 
        355                 360                 365             


Arg Gln Arg Leu Val Glu Xaa His Ala Xaa Arg Val Ile Ala Leu Ile 
    370                 375                 380                 


Asn Asp Gln Arg Arg Ala Ala Leu Glu Gly Phe Leu Ala Ala Leu Gln 
385                 390                 395                 400 


Ala Asp Pro Pro Gln Ala Glu Arg Val Leu Leu Ala Leu Arg Arg Tyr 
                405                 410                 415     


Leu Arg Ala Glu Gln Lys Glu Gln Arg His Xaa Leu Arg His Tyr Gln 
            420                 425                 430         


His Val Ala Ala Val Asp Pro Glu Lys Ala Gln Gln Met Arg Phe Gln 
        435                 440                 445             


Val His Xaa His Leu Gln Val Ile Glu Glu Arg Val Asn Gln Ser Leu 
    450                 455                 460                 


Gly Leu Leu Asp Gln Asn Pro His Leu Ala Gln Glu Leu Arg Pro Gln 
465                 470                 475                 480 


Ile Gln Glu Leu Leu His Ser Glu His Leu Gly Pro Ser Glu Leu Glu 
                485                 490                 495     


Ala Pro Ala Pro Gly Gly Ser Ser Glu Asp Lys Gly Gly Leu Gln Pro 
            500                 505                 510         


Pro Asp Ser Lys Asp Ala Asp Xaa Pro Met Xaa Leu Pro Lys Gly Ser 
        515                 520                 525             


Xaa Glu Gln Asp Ala Ala Ser Pro Glu Lys Glu Lys Met Asn Pro Leu 
    530                 535                 540                 


Glu Gln Tyr Glu Arg Lys Val Asn Ala Ser Val Pro Arg Gly Phe Pro 
545                 550                 555                 560 


Phe His Ser Ser Glu Ile Gln Arg Asp Glu Leu Ala Pro Ala Gly Xaa 
                565                 570                 575     


Gly Val Ser Arg Glu Ala Val Ser Gly Leu Leu Ile Met Gly Ala Gly 
            580                 585                 590         


Gly Gly Ser Leu Ile Val Leu Ser Met Leu Leu Leu Arg Arg Lys Lys 
        595                 600                 605             


Pro Tyr Gly Ala Ile Ser His Gly Val Val Glu Val Asp Pro Met Leu 
    610                 615                 620                 


Xaa Leu Glu Glu Gln Gln Leu Arg Glu Leu Gln Arg His Gly Tyr Glu 
625                 630                 635                 640 


Asn Pro Xaa Tyr Arg Phe Leu Glu Glu Arg Pro 
                645                 650     


<210> 2565
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(106)
<223> Selenocysteine

<400> 2565
Met Gly Pro Ala Ser Pro Ala Ala Arg Gly Leu Ser Arg Arg Pro Gly 
1               5                   10                  15      


Gln Pro Pro Leu Pro Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Arg 
            20                  25                  30          


Ala Gln Pro Ala Ile Gly Ser Leu Ala Gly Gly Ser Pro Gly Ala Ala 
        35                  40                  45              


Glu Xaa His Ser Ala Leu Asp Ala Val Ser Gly Xaa Arg Ser Ala Cys 
    50                  55                  60                  


Trp Ser Xaa Ala Asp Arg Cys Xaa Arg Ser Cys Arg Leu His Val Trp 
65                  70                  75                  80  


Ser Arg Leu Arg Arg Pro Ser Pro Trp Ser Ala Gly Ala Gly Val Pro 
                85                  90                  95      


Gly Ala Ala Ala Ala Pro Xaa Pro Xaa Xaa Arg Leu Cys Pro Ser Ala 
            100                 105                 110         


Ala Cys Leu Val Asn Leu 
        115             


<210> 2566
<211> 611
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<400> 2566
Met Leu Ala Ser Leu Glu Lys Asp Lys Xaa Ala Pro Gly Ser Ala Gln 
1               5                   10                  15      


Val Ala Gly Leu Cys Gly Arg Leu Xaa Leu His Arg Asp Leu Arg Xaa 
            20                  25                  30          


Gly Arg Trp Glu Pro Asp Pro Gln Arg Ser Arg Arg Cys Leu Arg Asp 
        35                  40                  45              


Pro Gln Arg Val Leu Glu Tyr Cys Arg Gln Met Tyr Pro Glu Leu Gln 
    50                  55                  60                  


Ile Ala Arg Val Glu Gln Ala Xaa Gln Ala Ile Pro Met Glu Arg Trp 
65                  70                  75                  80  


Cys Gly Gly Ser Arg Ser Gly Ser Cys Ala His Pro His His Gln Val 
                85                  90                  95      


Val Pro Phe Arg Cys Leu Pro Gly Glu Phe Val Ser Glu Ala Leu Leu 
            100                 105                 110         


Val Pro Glu Gly Cys Arg Phe Leu His Gln Glu Arg Met Asp Gln Cys 
        115                 120                 125             


Glu Ser Ser Xaa Arg Arg His Gln Glu Ala Gln Glu Ala Cys Ser Ser 
    130                 135                 140                 


Gln Gly Leu Ile Leu His Gly Ser Gly Met Leu Leu Pro Cys Gly Ser 
145                 150                 155                 160 


Asp Arg Phe Arg Gly Val Glu Tyr Val Cys Cys Pro Pro Pro Gly Xaa 
                165                 170                 175     


Pro Asp Pro Ser Gly Xaa Ala Val Gly Asp Pro Ser Xaa Arg Ser Trp 
            180                 185                 190         


Pro Pro Gly Ser Arg Val Glu Gly Ala Glu Asp Glu Glu Glu Glu Glu 
        195                 200                 205             


Ser Phe Pro Gln Pro Val Asp Asp Tyr Phe Val Glu Pro Pro Gln Ala 
    210                 215                 220                 


Glu Glu Glu Glu Glu Xaa Val Pro Pro Pro Ser Ser His Xaa Leu Ala 
225                 230                 235                 240 


Val Val Gly Lys Val Xaa Pro Xaa Pro Arg Pro Xaa Asp Gly Val Asp 
                245                 250                 255     


Ile Tyr Phe Gly Met Pro Gly Glu Ile Ser Glu His Glu Gly Phe Leu 
            260                 265                 270         


Arg Ala Lys Met Asp Leu Glu Glu Arg Arg Met Arg Gln Ile Asn Glu 
        275                 280                 285             


Val Met Arg Glu Trp Ala Met Ala Asp Asn Gln Ser Lys Asn Leu Pro 
    290                 295                 300                 


Lys Ala Asp Arg Gln Ala Leu Asn Glu His Phe Gln Ser Ile Leu Gln 
305                 310                 315                 320 


Xaa Leu Glu Glu Gln Val Ser Gly Glu Arg Gln Arg Leu Val Glu Xaa 
                325                 330                 335     


His Ala Xaa Arg Val Ile Ala Leu Ile Asn Asp Gln Arg Arg Ala Ala 
            340                 345                 350         


Leu Glu Gly Phe Leu Ala Ala Leu Gln Ala Asp Pro Pro Gln Ala Glu 
        355                 360                 365             


Arg Val Leu Leu Ala Leu Arg Arg Tyr Leu Arg Ala Glu Gln Lys Glu 
    370                 375                 380                 


Gln Arg His Xaa Leu Arg His Tyr Gln His Val Ala Ala Val Asp Pro 
385                 390                 395                 400 


Glu Lys Ala Gln Gln Met Arg Phe Gln Val His Xaa His Leu Gln Val 
                405                 410                 415     


Ile Glu Glu Arg Val Asn Gln Ser Leu Gly Leu Leu Asp Gln Asn Pro 
            420                 425                 430         


His Leu Ala Gln Glu Leu Arg Pro Gln Ile Gln Glu Leu Leu His Ser 
        435                 440                 445             


Glu His Leu Gly Pro Ser Glu Leu Glu Ala Pro Ala Pro Gly Gly Ser 
    450                 455                 460                 


Ser Glu Asp Lys Gly Gly Leu Gln Pro Pro Asp Ser Lys Asp Asp Xaa 
465                 470                 475                 480 


Pro Met Xaa Leu Pro Lys Gly Ser Xaa Glu Gln Asp Ala Ala Ser Pro 
                485                 490                 495     


Glu Lys Glu Lys Met Asn Pro Leu Glu Gln Tyr Glu Arg Lys Val Asn 
            500                 505                 510         


Ala Ser Val Pro Arg Gly Phe Pro Phe His Ser Ser Glu Ile Gln Arg 
        515                 520                 525             


Asp Glu Leu Ala Pro Ala Gly Xaa Gly Val Ser Arg Glu Ala Val Ser 
    530                 535                 540                 


Gly Leu Leu Ile Met Gly Ala Gly Gly Gly Ser Leu Ile Val Leu Ser 
545                 550                 555                 560 


Met Leu Leu Leu Arg Arg Lys Lys Pro Tyr Gly Ala Ile Ser His Gly 
                565                 570                 575     


Val Val Glu Val Asp Pro Met Leu Xaa Leu Glu Glu Gln Gln Leu Arg 
            580                 585                 590         


Glu Leu Gln Arg His Gly Tyr Glu Asn Pro Xaa Tyr Arg Phe Leu Glu 
        595                 600                 605             


Glu Arg Pro 
    610     


<210> 2567
<211> 173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<400> 2567
Met Tyr Pro Glu Leu Gln Ile Ala Arg Val Glu Gln Ala Xaa Gln Ala 
1               5                   10                  15      


Ile Pro Met Glu Arg Trp Cys Gly Gly Ser Arg Ser Gly Ser Cys Ala 
            20                  25                  30          


His Pro His His Gln Val Val Pro Phe Arg Cys Leu Pro Gly Glu Phe 
        35                  40                  45              


Val Ser Glu Ala Leu Leu Val Pro Glu Gly Cys Arg Phe Leu His Gln 
    50                  55                  60                  


Glu Arg Met Asp Gln Cys Glu Ser Ser Xaa Arg Arg His Gln Glu Ala 
65                  70                  75                  80  


Gln Glu Ala Cys Ser Ser Gln Gly Leu Ile Leu His Gly Ser Gly Met 
                85                  90                  95      


Leu Leu Pro Cys Gly Ser Asp Arg Phe Arg Gly Val Glu Tyr Val Cys 
            100                 105                 110         


Cys Pro Pro Pro Gly Xaa Pro Asp Pro Ser Gly Xaa Ala Val Gly Asp 
        115                 120                 125             


Pro Ser Xaa Arg Ser Trp Pro Pro Gly Ser Arg Val Glu Gly Ala Glu 
    130                 135                 140                 


Asp Glu Glu Glu Glu Glu Ser Phe Pro Gln Pro Val Asp Asp Tyr Phe 
145                 150                 155                 160 


Val Glu Pro Pro Gln Ala Glu Glu Glu Glu Glu Xaa Val 
                165                 170             


<210> 2568
<211> 294
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<400> 2568
Met Tyr Pro Glu Leu Gln Ile Ala Arg Val Glu Gln Ala Xaa Gln Ala 
1               5                   10                  15      


Ile Pro Met Glu Arg Trp Cys Gly Gly Ser Arg Ser Gly Ser Cys Ala 
            20                  25                  30          


His Pro His His Gln Val Val Pro Phe Arg Cys Leu Pro Gly Glu Phe 
        35                  40                  45              


Val Ser Glu Ala Leu Leu Val Pro Glu Gly Cys Arg Phe Leu His Gln 
    50                  55                  60                  


Glu Arg Met Asp Gln Cys Glu Ser Ser Xaa Arg Arg His Gln Glu Ala 
65                  70                  75                  80  


Gln Glu Ala Cys Ser Ser Gln Gly Leu Ile Leu His Gly Ser Gly Met 
                85                  90                  95      


Leu Leu Pro Cys Gly Ser Asp Arg Phe Arg Gly Val Glu Tyr Val Cys 
            100                 105                 110         


Cys Pro Pro Pro Gly Xaa Pro Asp Pro Ser Gly Xaa Ala Val Gly Asp 
        115                 120                 125             


Pro Ser Xaa Arg Ser Trp Pro Pro Gly Ser Arg Val Glu Gly Ala Glu 
    130                 135                 140                 


Asp Glu Glu Glu Glu Glu Ser Phe Pro Gln Pro Val Asp Asp Tyr Phe 
145                 150                 155                 160 


Val Glu Pro Pro Gln Ala Glu Glu Glu Glu Glu Xaa Val Pro Pro Pro 
                165                 170                 175     


Ser Ser His Xaa Leu Ala Val Val Gly Lys Val Xaa Pro Xaa Pro Arg 
            180                 185                 190         


Pro Xaa Asp Gly Val Asp Ile Tyr Phe Gly Met Pro Gly Glu Ile Ser 
        195                 200                 205             


Glu His Glu Gly Phe Leu Arg Ala Lys Met Asp Leu Glu Glu Arg Arg 
    210                 215                 220                 


Met Arg Gln Ile Asn Glu Val Met Arg Glu Trp Ala Met Ala Asp Asn 
225                 230                 235                 240 


Gln Ser Lys Asn Leu Pro Lys Ala Asp Arg Gln Ala Leu Asn Glu His 
                245                 250                 255     


Phe Gln Ser Ile Leu Gln Xaa Leu Glu Glu Gln Val Ser Gly Glu Arg 
            260                 265                 270         


Gln Arg Leu Val Glu Xaa His Ala Xaa Arg Val Ile Ala Leu Ile Asn 
        275                 280                 285             


Asp Gln Arg Arg Ala Ala 
    290                 


<210> 2569
<211> 222
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<400> 2569
Xaa Glu Trp Ala Met Ala Asp Asn Gln Ser Lys Asn Leu Pro Lys Ala 
1               5                   10                  15      


Asp Arg Gln Ala Leu Asn Glu Ala Glu Arg Val Leu Leu Ala Leu Arg 
            20                  25                  30          


Arg Tyr Leu Arg Ala Glu Gln Lys Glu Gln Arg His Xaa Leu Arg His 
        35                  40                  45              


Tyr Gln His Val Ala Ala Val Asp Pro Glu Lys Ala Gln Gln Met Arg 
    50                  55                  60                  


Phe Gln Val His Xaa His Leu Gln Val Ile Glu Glu Arg Val Asn Gln 
65                  70                  75                  80  


Ser Leu Gly Leu Leu Asp Gln Asn Pro His Leu Ala Gln Glu Leu Arg 
                85                  90                  95      


Pro Gln Ile Gln Glu Leu Leu His Ser Glu His Leu Gly Pro Ser Glu 
            100                 105                 110         


Leu Glu Ala Pro Ala Pro Gly Gly Ser Ser Glu Asp Lys Gly Gly Leu 
        115                 120                 125             


Gln Pro Pro Asp Ser Lys Asp Asp Xaa Pro Met Xaa Leu Pro Lys Gly 
    130                 135                 140                 


Ser Xaa Glu Gln Asp Ala Ala Ser Pro Glu Lys Glu Lys Met Asn Pro 
145                 150                 155                 160 


Leu Glu Gln Tyr Glu Arg Lys Val Asn Ala Ser Val Pro Arg Gly Phe 
                165                 170                 175     


Pro Phe His Ser Ser Glu Ile Gln Arg Asp Glu Leu Ala Pro Ala Gly 
            180                 185                 190         


Xaa Gly Val Ser Arg Glu Ala Val Ser Gly Leu Leu Ile Met Gly Ala 
        195                 200                 205             


Gly Gly Gly Ser Leu Ile Val Leu Ser Met Leu Leu Leu Arg 
    210                 215                 220         


<210> 2570
<211> 289
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<400> 2570
Xaa Gln Ser Ile Leu Gln Xaa Leu Glu Glu Gln Val Ser Gly Glu Arg 
1               5                   10                  15      


Gln Arg Leu Val Glu Xaa His Ala Xaa Arg Val Ile Ala Leu Ile Asn 
            20                  25                  30          


Asp Gln Arg Arg Ala Ala Leu Glu Gly Phe Leu Ala Ala Leu Gln Ala 
        35                  40                  45              


Asp Pro Pro Gln Ala Glu Arg Val Leu Leu Ala Leu Arg Arg Tyr Leu 
    50                  55                  60                  


Arg Ala Glu Gln Lys Glu Gln Arg His Xaa Leu Arg His Tyr Gln His 
65                  70                  75                  80  


Val Ala Ala Val Asp Pro Glu Lys Ala Gln Gln Met Arg Phe Gln Val 
                85                  90                  95      


His Xaa His Leu Gln Val Ile Glu Glu Arg Val Asn Gln Ser Leu Gly 
            100                 105                 110         


Leu Leu Asp Gln Asn Pro His Leu Ala Gln Glu Leu Arg Pro Gln Ile 
        115                 120                 125             


Gln Glu Leu Leu His Ser Glu His Leu Gly Pro Ser Glu Leu Glu Ala 
    130                 135                 140                 


Pro Ala Pro Gly Gly Ser Ser Glu Asp Lys Gly Gly Leu Gln Pro Pro 
145                 150                 155                 160 


Asp Ser Lys Asp Gly Ser Xaa Glu Gln Asp Ala Ala Ser Pro Glu Lys 
                165                 170                 175     


Glu Lys Met Asn Pro Leu Glu Gln Tyr Glu Arg Lys Val Asn Ala Ser 
            180                 185                 190         


Val Pro Arg Gly Phe Pro Phe His Ser Ser Glu Ile Gln Arg Asp Glu 
        195                 200                 205             


Leu Ala Pro Ala Gly Xaa Gly Val Ser Arg Glu Ala Val Ser Gly Leu 
    210                 215                 220                 


Leu Ile Met Gly Ala Gly Gly Gly Ser Leu Ile Val Leu Ser Met Leu 
225                 230                 235                 240 


Leu Leu Arg Arg Lys Lys Pro Tyr Gly Ala Ile Ser His Gly Val Val 
                245                 250                 255     


Glu Val Asp Pro Met Leu Xaa Leu Glu Glu Gln Gln Leu Arg Glu Leu 
            260                 265                 270         


Gln Arg His Gly Tyr Glu Asn Pro Xaa Tyr Arg Phe Leu Glu Glu Arg 
        275                 280                 285             


Pro 
    


<210> 2571
<211> 158
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<400> 2571
Met Ala Ala Xaa Gly Xaa Ala Ala Ala Ala Ala Xaa Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Leu Ala Ala Asn Ala Gly Xaa Gly Phe Ala Val 
            20                  25                  30          


Ala Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val 
        35                  40                  45              


Asn Ile Gln Xaa Gly Lys Trp Glu Pro Asp Pro Xaa Gly Xaa Lys Ser 
    50                  55                  60                  


Cys Phe Glu Xaa Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr 
65                  70                  75                  80  


Pro Glu Leu Gln Ile Xaa Asn Val Met Glu Ala Asn Gln Arg Val Ser 
                85                  90                  95      


Ile Asp Asn Trp Cys Arg Arg Asp Lys Lys Gln Cys Lys Ser Arg Phe 
            100                 105                 110         


Val Xaa Pro Phe Lys Cys Leu Val Gly Glu Phe Val Ser Asp Val Leu 
        115                 120                 125             


Leu Val Pro Glu Lys Cys Gln Phe Phe His Lys Glu Arg Met Glu Val 
    130                 135                 140                 


Cys Glu Asn His Gln His Trp His Xaa Val Val Lys Glu Val 
145                 150                 155             


<210> 2572
<211> 35
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<400> 2572
Met Ala Ala Xaa Gly Xaa Ala Ala Ala Ala Ala Xaa Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Xaa Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu 
        35  


<210> 2573
<211> 116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 2573
Met Ala Ala Xaa Gly Xaa Ala Ala Ala Ala Ala Xaa Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Xaa Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Xaa Gly Phe Ala Val Ala 
        35                  40                  45              


Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
    50                  55                  60                  


Ile Gln Xaa Gly Lys Trp Glu Pro Asp Pro Xaa Gly Xaa Lys Ser Cys 
65                  70                  75                  80  


Phe Glu Xaa Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro 
                85                  90                  95      


Glu Leu Gln Ile Xaa Asn Ser Gly Trp Arg Cys Val Arg Ile Xaa Ser 
            100                 105                 110         


Xaa Gly Xaa Arg 
        115     


<210> 2574
<211> 695
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<400> 2574
Met Ala Ala Xaa Gly Xaa Ala Ala Ala Ala Ala Xaa Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Xaa Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Xaa Gly Phe Ala Val Ala 
        35                  40                  45              


Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
    50                  55                  60                  


Ile Gln Xaa Gly Lys Trp Glu Pro Asp Pro Xaa Gly Xaa Lys Ser Cys 
65                  70                  75                  80  


Phe Glu Xaa Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro 
                85                  90                  95      


Glu Leu Gln Ile Xaa Asn Val Met Glu Ala Asn Gln Arg Val Ser Ile 
            100                 105                 110         


Asp Asn Trp Cys Arg Arg Asp Lys Lys Gln Cys Lys Ser Arg Phe Val 
        115                 120                 125             


Xaa Pro Phe Lys Cys Leu Val Gly Glu Phe Val Ser Asp Val Leu Leu 
    130                 135                 140                 


Val Pro Glu Lys Cys Gln Phe Phe His Lys Glu Arg Met Glu Val Cys 
145                 150                 155                 160 


Glu Asn His Gln His Trp His Xaa Val Val Lys Glu Ala Cys Leu Xaa 
                165                 170                 175     


Gln Gly Met Xaa Leu Tyr Ser Tyr Gly Met Leu Leu Pro Cys Gly Val 
            180                 185                 190         


Asp Gln Phe His Gly Xaa Glu Tyr Val Cys Cys Pro Gln Xaa Lys Ile 
        195                 200                 205             


Ile Gly Ser Val Ser Lys Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu Glu Asp Glu Glu Glu Asp Tyr Asp Val Tyr Lys Ser Glu Phe 
225                 230                 235                 240 


Pro Xaa Glu Ala Asp Leu Glu Asp Phe Xaa Glu Ala Ala Val Asp Glu 
                245                 250                 255     


Asp Asp Glu Asp Glu Glu Glu Gly Glu Glu Val Val Glu Asp Arg Asp 
            260                 265                 270         


Tyr Tyr Tyr Asp Xaa Phe Lys Gly Asp Asp Tyr Asn Glu Glu Asn Pro 
        275                 280                 285             


Xaa Glu Pro Gly Ser Asp Gly Xaa Met Ser Asp Lys Glu Ile Xaa His 
    290                 295                 300                 


Asp Val Lys Val Pro Pro Xaa Pro Leu Pro Xaa Asn Asp Val Asp Val 
305                 310                 315                 320 


Tyr Phe Glu Xaa Ser Ala Asp Asp Asn Glu His Ala Arg Phe Gln Lys 
                325                 330                 335     


Ala Lys Glu Gln Leu Glu Ile Arg His Arg Asn Arg Met Asp Arg Val 
            340                 345                 350         


Lys Lys Glu Trp Glu Glu Ala Glu Leu Gln Ala Lys Asn Leu Pro Lys 
        355                 360                 365             


Ala Glu Arg Gln Xaa Leu Ile Gln His Phe Gln Ala Met Val Lys Ala 
    370                 375                 380                 


Leu Glu Lys Glu Ala Ala Ser Glu Lys Gln Gln Leu Val Glu Xaa His 
385                 390                 395                 400 


Leu Ala Arg Val Glu Ala Met Leu Asn Asp Arg Arg Arg Met Ala Leu 
                405                 410                 415     


Glu Asn Tyr Leu Ala Ala Leu Gln Ser Asp Pro Pro Arg Pro His Arg 
            420                 425                 430         


Ile Leu Gln Ala Leu Arg Arg Tyr Val Arg Ala Glu Asn Lys Asp Arg 
        435                 440                 445             


Leu His Xaa Ile Arg His Tyr Gln His Val Leu Ala Val Asp Pro Glu 
    450                 455                 460                 


Lys Ala Ala Gln Met Lys Ser Gln Val Met Xaa His Leu His Val Ile 
465                 470                 475                 480 


Glu Glu Arg Arg Asn Gln Ser Leu Ser Leu Leu Tyr Lys Val Pro Tyr 
                485                 490                 495     


Val Ala Gln Glu Ile Gln Glu Glu Ile Asp Glu Leu Leu Gln Glu Gln 
            500                 505                 510         


Arg Ala Asp Met Asp Gln Phe Xaa Ala Ser Ile Ser Glu Xaa Pro Val 
        515                 520                 525             


Asp Val Arg Val Ser Ser Glu Glu Ser Glu Glu Ile Pro Pro Phe His 
    530                 535                 540                 


Pro Phe His Pro Phe Pro Ala Leu Pro Glu Asn Glu Gly Ser Gly Val 
545                 550                 555                 560 


Gly Glu Gln Asp Gly Gly Leu Ile Gly Ala Glu Glu Lys Val Ile Asn 
                565                 570                 575     


Ser Lys Asn Lys Val Asp Glu Asn Met Val Ile Asp Glu Xaa Leu Asp 
            580                 585                 590         


Val Lys Glu Met Ile Phe Asn Ala Glu Arg Val Gly Gly Leu Glu Glu 
        595                 600                 605             


Glu Arg Glu Ser Val Gly Pro Leu Arg Glu Asp Phe Ser Leu Ser Ser 
    610                 615                 620                 


Ser Ala Leu Ile Gly Leu Leu Val Ile Ala Val Ala Ile Ala Xaa Val 
625                 630                 635                 640 


Ile Val Ile Ser Leu Val Met Leu Arg Lys Arg Gln Tyr Gly Xaa Ile 
                645                 650                 655     


Ser His Gly Ile Val Glu Val Asp Pro Met Leu Xaa Pro Glu Glu Arg 
            660                 665                 670         


His Leu Asn Lys Met Gln Asn His Gly Tyr Glu Asn Pro Xaa Tyr Lys 
        675                 680                 685             


Tyr Leu Glu Gln Met Gln Ile 
    690                 695 


<210> 2575
<211> 751
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<400> 2575
Met Ala Ala Xaa Gly Xaa Ala Ala Ala Ala Ala Xaa Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Xaa Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Xaa Gly Phe Ala Val Ala 
        35                  40                  45              


Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
    50                  55                  60                  


Ile Gln Xaa Gly Lys Trp Glu Pro Asp Pro Xaa Gly Xaa Lys Ser Cys 
65                  70                  75                  80  


Phe Glu Xaa Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro 
                85                  90                  95      


Glu Leu Gln Ile Xaa Asn Val Met Glu Ala Asn Gln Arg Val Ser Ile 
            100                 105                 110         


Asp Asn Trp Cys Arg Arg Asp Lys Lys Gln Cys Lys Ser Arg Phe Val 
        115                 120                 125             


Xaa Pro Phe Lys Cys Leu Val Gly Glu Phe Val Ser Asp Val Leu Leu 
    130                 135                 140                 


Val Pro Glu Lys Cys Gln Phe Phe His Lys Glu Arg Met Glu Val Cys 
145                 150                 155                 160 


Glu Asn His Gln His Trp His Xaa Val Val Lys Glu Ala Cys Leu Xaa 
                165                 170                 175     


Gln Gly Met Xaa Leu Tyr Ser Tyr Gly Met Leu Leu Pro Cys Gly Val 
            180                 185                 190         


Asp Gln Phe His Gly Xaa Glu Tyr Val Cys Cys Pro Gln Xaa Lys Ile 
        195                 200                 205             


Ile Gly Ser Val Ser Lys Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu Glu Asp Glu Glu Glu Asp Tyr Asp Val Tyr Lys Ser Glu Phe 
225                 230                 235                 240 


Pro Xaa Glu Ala Asp Leu Glu Asp Phe Xaa Glu Ala Ala Val Asp Glu 
                245                 250                 255     


Asp Asp Glu Asp Glu Glu Glu Gly Glu Glu Val Val Glu Asp Arg Asp 
            260                 265                 270         


Tyr Tyr Tyr Asp Xaa Phe Lys Gly Asp Asp Tyr Asn Glu Glu Asn Pro 
        275                 280                 285             


Xaa Glu Pro Gly Ser Asp Gly Xaa Met Ser Asp Lys Glu Ile Xaa His 
    290                 295                 300                 


Asp Val Lys Ala Val Cys Ser Gln Glu Ala Met Xaa Gly Pro Cys Arg 
305                 310                 315                 320 


Ala Val Met Pro Arg Trp Tyr Phe Asp Leu Ser Lys Gly Lys Cys Val 
                325                 330                 335     


Arg Phe Ile Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Glu Ser 
            340                 345                 350         


Glu Asp Tyr Cys Met Ala Val Cys Lys Ala Met Ile Pro Pro Xaa Pro 
        355                 360                 365             


Leu Pro Xaa Asn Asp Val Asp Val Tyr Phe Glu Xaa Ser Ala Asp Asp 
    370                 375                 380                 


Asn Glu His Ala Arg Phe Gln Lys Ala Lys Glu Gln Leu Glu Ile Arg 
385                 390                 395                 400 


His Arg Asn Arg Met Asp Arg Val Lys Lys Glu Trp Glu Glu Ala Glu 
                405                 410                 415     


Leu Gln Ala Lys Asn Leu Pro Lys Ala Glu Arg Gln Xaa Leu Ile Gln 
            420                 425                 430         


His Phe Gln Ala Met Val Lys Ala Leu Glu Lys Glu Ala Ala Ser Glu 
        435                 440                 445             


Lys Gln Gln Leu Val Glu Xaa His Leu Ala Arg Val Glu Ala Met Leu 
    450                 455                 460                 


Asn Asp Arg Arg Arg Met Ala Leu Glu Asn Tyr Leu Ala Ala Leu Gln 
465                 470                 475                 480 


Ser Asp Pro Pro Arg Pro His Arg Ile Leu Gln Ala Leu Arg Arg Tyr 
                485                 490                 495     


Val Arg Ala Glu Asn Lys Asp Arg Leu His Xaa Ile Arg His Tyr Gln 
            500                 505                 510         


His Val Leu Ala Val Asp Pro Glu Lys Ala Ala Gln Met Lys Ser Gln 
        515                 520                 525             


Val Met Xaa His Leu His Val Ile Glu Glu Arg Arg Asn Gln Ser Leu 
    530                 535                 540                 


Ser Leu Leu Tyr Lys Val Pro Tyr Val Ala Gln Glu Ile Gln Glu Glu 
545                 550                 555                 560 


Ile Asp Glu Leu Leu Gln Glu Gln Arg Ala Asp Met Asp Gln Phe Xaa 
                565                 570                 575     


Ala Ser Ile Ser Glu Xaa Pro Val Asp Val Arg Val Ser Ser Glu Glu 
            580                 585                 590         


Ser Glu Glu Ile Pro Pro Phe His Pro Phe His Pro Phe Pro Ala Leu 
        595                 600                 605             


Pro Glu Asn Glu Gly Ser Gly Val Gly Glu Gln Asp Gly Gly Leu Ile 
    610                 615                 620                 


Gly Ala Glu Glu Lys Val Ile Asn Ser Lys Asn Lys Val Asp Glu Asn 
625                 630                 635                 640 


Met Val Ile Asp Glu Xaa Leu Asp Val Lys Glu Met Ile Phe Asn Ala 
                645                 650                 655     


Glu Arg Val Gly Gly Leu Glu Glu Glu Arg Glu Ser Val Gly Pro Leu 
            660                 665                 670         


Arg Glu Asp Phe Ser Leu Ser Ser Ser Ala Leu Ile Gly Leu Leu Val 
        675                 680                 685             


Ile Ala Val Ala Ile Ala Xaa Val Ile Val Ile Ser Leu Val Met Leu 
    690                 695                 700                 


Arg Lys Arg Gln Tyr Gly Xaa Ile Ser His Gly Ile Val Glu Val Asp 
705                 710                 715                 720 


Pro Met Leu Xaa Pro Glu Glu Arg His Leu Asn Lys Met Gln Asn His 
                725                 730                 735     


Gly Tyr Glu Asn Pro Xaa Tyr Lys Tyr Leu Glu Gln Met Gln Ile 
            740                 745                 750     


<210> 2576
<211> 763
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<400> 2576
Met Ala Ala Xaa Gly Xaa Ala Ala Ala Ala Ala Xaa Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Xaa Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Xaa Gly Phe Ala Val Ala 
        35                  40                  45              


Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
    50                  55                  60                  


Ile Gln Xaa Gly Lys Trp Glu Pro Asp Pro Xaa Gly Xaa Lys Ser Cys 
65                  70                  75                  80  


Phe Glu Xaa Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro 
                85                  90                  95      


Glu Leu Gln Ile Xaa Asn Val Met Glu Ala Asn Gln Arg Val Ser Ile 
            100                 105                 110         


Asp Asn Trp Cys Arg Arg Asp Lys Lys Gln Cys Lys Ser Arg Phe Val 
        115                 120                 125             


Xaa Pro Phe Lys Cys Leu Val Gly Glu Phe Val Ser Asp Val Leu Leu 
    130                 135                 140                 


Val Pro Glu Lys Cys Gln Phe Phe His Lys Glu Arg Met Glu Val Cys 
145                 150                 155                 160 


Glu Asn His Gln His Trp His Xaa Val Val Lys Glu Ala Cys Leu Xaa 
                165                 170                 175     


Gln Gly Met Xaa Leu Tyr Ser Tyr Gly Met Leu Leu Pro Cys Gly Val 
            180                 185                 190         


Asp Gln Phe His Gly Xaa Glu Tyr Val Cys Cys Pro Gln Xaa Lys Ile 
        195                 200                 205             


Ile Gly Ser Val Ser Lys Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu Glu Asp Glu Glu Glu Asp Tyr Asp Val Tyr Lys Ser Glu Phe 
225                 230                 235                 240 


Pro Xaa Glu Ala Asp Leu Glu Asp Phe Xaa Glu Ala Ala Val Asp Glu 
                245                 250                 255     


Asp Asp Glu Asp Glu Glu Glu Gly Glu Glu Val Val Glu Asp Arg Asp 
            260                 265                 270         


Tyr Tyr Tyr Asp Xaa Phe Lys Gly Asp Asp Tyr Asn Glu Glu Asn Pro 
        275                 280                 285             


Xaa Glu Pro Gly Ser Asp Gly Xaa Met Ser Asp Lys Glu Ile Xaa His 
    290                 295                 300                 


Asp Val Lys Ala Val Cys Ser Gln Glu Ala Met Xaa Gly Pro Cys Arg 
305                 310                 315                 320 


Ala Val Met Pro Arg Trp Tyr Phe Asp Leu Ser Lys Gly Lys Cys Val 
                325                 330                 335     


Arg Phe Ile Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Glu Ser 
            340                 345                 350         


Glu Asp Tyr Cys Met Ala Val Cys Lys Ala Met Ile Pro Pro Xaa Pro 
        355                 360                 365             


Leu Pro Xaa Asn Asp Val Asp Val Tyr Phe Glu Xaa Ser Ala Asp Asp 
    370                 375                 380                 


Asn Glu His Ala Arg Phe Gln Lys Ala Lys Glu Gln Leu Glu Ile Arg 
385                 390                 395                 400 


His Arg Asn Arg Met Asp Arg Val Lys Lys Glu Trp Glu Glu Ala Glu 
                405                 410                 415     


Leu Gln Ala Lys Asn Leu Pro Lys Ala Glu Arg Gln Xaa Leu Ile Gln 
            420                 425                 430         


His Phe Gln Ala Met Val Lys Ala Leu Glu Lys Glu Ala Ala Ser Glu 
        435                 440                 445             


Lys Gln Gln Leu Val Glu Xaa His Leu Ala Arg Val Glu Ala Met Leu 
    450                 455                 460                 


Asn Asp Arg Arg Arg Met Ala Leu Glu Asn Tyr Leu Ala Ala Leu Gln 
465                 470                 475                 480 


Ser Asp Pro Pro Arg Pro His Arg Ile Leu Gln Ala Leu Arg Arg Tyr 
                485                 490                 495     


Val Arg Ala Glu Asn Lys Asp Arg Leu His Xaa Ile Arg His Tyr Gln 
            500                 505                 510         


His Val Leu Ala Val Asp Pro Glu Lys Ala Ala Gln Met Lys Ser Gln 
        515                 520                 525             


Val Met Xaa His Leu His Val Ile Glu Glu Arg Arg Asn Gln Ser Leu 
    530                 535                 540                 


Ser Leu Leu Tyr Lys Val Pro Tyr Val Ala Gln Glu Ile Gln Glu Glu 
545                 550                 555                 560 


Ile Asp Glu Leu Leu Gln Glu Gln Arg Ala Asp Met Asp Gln Phe Xaa 
                565                 570                 575     


Ala Ser Ile Ser Glu Xaa Pro Val Asp Val Arg Val Ser Ser Glu Glu 
            580                 585                 590         


Ser Glu Glu Ile Pro Pro Phe His Pro Phe His Pro Phe Pro Ala Leu 
        595                 600                 605             


Pro Glu Asn Glu Asp Xaa Gln Pro Glu Leu Tyr His Pro Met Lys Lys 
    610                 615                 620                 


Gly Ser Gly Val Gly Glu Gln Asp Gly Gly Leu Ile Gly Ala Glu Glu 
625                 630                 635                 640 


Lys Val Ile Asn Ser Lys Asn Lys Val Asp Glu Asn Met Val Ile Asp 
                645                 650                 655     


Glu Xaa Leu Asp Val Lys Glu Met Ile Phe Asn Ala Glu Arg Val Gly 
            660                 665                 670         


Gly Leu Glu Glu Glu Arg Glu Ser Val Gly Pro Leu Arg Glu Asp Phe 
        675                 680                 685             


Ser Leu Ser Ser Ser Ala Leu Ile Gly Leu Leu Val Ile Ala Val Ala 
    690                 695                 700                 


Ile Ala Xaa Val Ile Val Ile Ser Leu Val Met Leu Arg Lys Arg Gln 
705                 710                 715                 720 


Tyr Gly Xaa Ile Ser His Gly Ile Val Glu Val Asp Pro Met Leu Xaa 
                725                 730                 735     


Pro Glu Glu Arg His Leu Asn Lys Met Gln Asn His Gly Tyr Glu Asn 
            740                 745                 750         


Pro Xaa Tyr Lys Tyr Leu Glu Gln Met Gln Ile 
        755                 760             


<210> 2577
<211> 522
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<400> 2577
Met Ala Ala Xaa Gly Xaa Ala Ala Ala Ala Ala Xaa Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Xaa Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Xaa Gly Phe Ala Val Ala 
        35                  40                  45              


Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
    50                  55                  60                  


Ile Gln Xaa Gly Lys Trp Glu Pro Asp Pro Xaa Gly Xaa Lys Ser Cys 
65                  70                  75                  80  


Phe Glu Xaa Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro 
                85                  90                  95      


Glu Leu Gln Ile Xaa Asn Val Met Glu Ala Asn Gln Arg Val Ser Ile 
            100                 105                 110         


Asp Asn Trp Cys Arg Arg Asp Lys Lys Gln Cys Lys Ser Arg Phe Val 
        115                 120                 125             


Xaa Pro Phe Lys Cys Leu Val Pro Pro Xaa Pro Leu Pro Xaa Asn Asp 
    130                 135                 140                 


Val Asp Val Tyr Phe Glu Xaa Ser Ala Asp Asp Asn Glu His Ala Arg 
145                 150                 155                 160 


Phe Gln Lys Ala Lys Glu Gln Leu Glu Ile Arg His Arg Asn Arg Met 
                165                 170                 175     


Asp Arg Val Lys Lys Glu Trp Glu Glu Ala Glu Leu Gln Ala Lys Asn 
            180                 185                 190         


Leu Pro Lys Ala Glu Arg Gln Xaa Leu Ile Gln His Phe Gln Ala Met 
        195                 200                 205             


Val Lys Ala Leu Glu Lys Glu Ala Ala Ser Glu Lys Gln Gln Leu Val 
    210                 215                 220                 


Glu Xaa His Leu Ala Arg Val Glu Ala Met Leu Asn Asp Arg Arg Arg 
225                 230                 235                 240 


Met Ala Leu Glu Asn Tyr Leu Ala Ala Leu Gln Ser Asp Pro Pro Arg 
                245                 250                 255     


Pro His Arg Ile Leu Gln Ala Leu Arg Arg Tyr Val Arg Ala Glu Asn 
            260                 265                 270         


Lys Asp Arg Leu His Xaa Ile Arg His Tyr Gln His Val Leu Ala Val 
        275                 280                 285             


Asp Pro Glu Lys Ala Ala Gln Met Lys Ser Gln Val Met Xaa His Leu 
    290                 295                 300                 


His Val Ile Glu Glu Arg Arg Asn Gln Ser Leu Ser Leu Leu Tyr Lys 
305                 310                 315                 320 


Val Pro Tyr Val Ala Gln Glu Ile Gln Glu Glu Ile Asp Glu Leu Leu 
                325                 330                 335     


Gln Glu Gln Arg Ala Asp Met Asp Gln Phe Xaa Ala Ser Ile Ser Glu 
            340                 345                 350         


Xaa Pro Val Asp Val Arg Val Ser Ser Glu Glu Ser Glu Glu Ile Pro 
        355                 360                 365             


Pro Phe His Pro Phe His Pro Phe Pro Ala Leu Pro Glu Asn Glu Gly 
    370                 375                 380                 


Ser Gly Val Gly Glu Gln Asp Gly Gly Leu Ile Gly Ala Glu Glu Lys 
385                 390                 395                 400 


Val Ile Asn Ser Lys Asn Lys Val Asp Glu Asn Met Val Ile Asp Glu 
                405                 410                 415     


Xaa Leu Asp Val Lys Glu Met Ile Phe Asn Ala Glu Arg Val Gly Gly 
            420                 425                 430         


Leu Glu Glu Glu Arg Glu Ser Val Gly Pro Leu Arg Glu Asp Phe Ser 
        435                 440                 445             


Leu Ser Ser Ser Ala Leu Ile Gly Leu Leu Val Ile Ala Val Ala Ile 
    450                 455                 460                 


Ala Xaa Val Ile Val Ile Ser Leu Val Met Leu Arg Lys Arg Gln Tyr 
465                 470                 475                 480 


Gly Xaa Ile Ser His Gly Ile Val Glu Val Asp Pro Met Leu Xaa Pro 
                485                 490                 495     


Glu Glu Arg His Leu Asn Lys Met Gln Asn His Gly Tyr Glu Asn Pro 
            500                 505                 510         


Xaa Tyr Lys Tyr Leu Glu Gln Met Gln Ile 
        515                 520         


<210> 2578
<211> 159
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<400> 2578
Met Ala Ala Xaa Gly Xaa Ala Ala Ala Ala Ala Xaa Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Xaa Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Ser Ser Gln Ile Cys Cys Ser Pro Arg Ser Phe Leu Ile 
        35                  40                  45              


Ser Xaa Leu Lys Cys Leu Ile Val Asp Glu Ile Asn Ala Leu Ala Ala 
    50                  55                  60                  


Asn Ala Gly Xaa Gly Phe Ala Val Ala Glu Pro Gln Ile Ala Met Phe 
65                  70                  75                  80  


Cys Gly Lys Leu Asn Met His Val Asn Ile Gln Xaa Gly Lys Trp Glu 
                85                  90                  95      


Pro Asp Pro Xaa Gly Xaa Lys Ser Cys Phe Glu Xaa Lys Glu Glu Val 
            100                 105                 110         


Leu Gln Tyr Cys Gln Glu Met Tyr Pro Glu Leu Gln Ile Xaa Asn Val 
        115                 120                 125             


Met Glu Ala Asn Gln Arg Val Ser Ile Asp Asn Trp Cys Arg Arg Asp 
    130                 135                 140                 


Lys Lys Gln Cys Lys Ser Arg Phe Val Xaa Pro Phe Lys Cys Leu 
145                 150                 155                 


<210> 2579
<211> 39
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<400> 2579
Met Ala Ala Xaa Gly Xaa Ala Ala Ala Ala Ala Xaa Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Xaa Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Trp Val Asn Leu 
        35                  


<210> 2580
<211> 761
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<400> 2580
Met Leu Arg Ala Pro Gly Glu Leu Pro Arg Gln Ala Ala Arg Cys Ser 
1               5                   10                  15      


Leu Cys Arg Leu Gly Pro Gly Arg Gly Arg Ala Phe Phe Lys Trp Arg 
            20                  25                  30          


Cys Leu Pro Ala Ser Val Asp Arg Gly Asn Pro Leu Trp Ala Leu Ala 
        35                  40                  45              


Ala Asn Ala Gly Xaa Gly Phe Ala Val Ala Glu Pro Gln Ile Ala Met 
    50                  55                  60                  


Phe Cys Gly Lys Leu Asn Met His Val Asn Ile Gln Xaa Gly Lys Trp 
65                  70                  75                  80  


Glu Pro Asp Pro Xaa Gly Xaa Lys Ser Cys Phe Glu Xaa Lys Glu Glu 
                85                  90                  95      


Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro Glu Leu Gln Ile Xaa Asn 
            100                 105                 110         


Val Met Glu Ala Asn Gln Arg Val Ser Ile Asp Asn Trp Cys Arg Arg 
        115                 120                 125             


Asp Lys Lys Gln Cys Lys Ser Arg Phe Val Xaa Pro Phe Lys Cys Leu 
    130                 135                 140                 


Val Gly Glu Phe Val Ser Asp Val Leu Leu Val Pro Glu Lys Cys Gln 
145                 150                 155                 160 


Phe Phe His Lys Glu Arg Met Glu Val Cys Glu Asn His Gln His Trp 
                165                 170                 175     


His Xaa Val Val Lys Glu Ala Cys Leu Xaa Gln Gly Met Xaa Leu Tyr 
            180                 185                 190         


Ser Tyr Gly Met Leu Leu Pro Cys Gly Val Asp Gln Phe His Gly Xaa 
        195                 200                 205             


Glu Tyr Val Cys Cys Pro Gln Xaa Lys Ile Ile Gly Ser Val Ser Lys 
    210                 215                 220                 


Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu 
225                 230                 235                 240 


Glu Asp Tyr Asp Val Tyr Lys Ser Glu Phe Pro Xaa Glu Ala Asp Leu 
                245                 250                 255     


Glu Asp Phe Xaa Glu Ala Ala Val Asp Glu Asp Asp Glu Asp Glu Glu 
            260                 265                 270         


Glu Gly Glu Glu Val Val Glu Asp Arg Asp Tyr Tyr Tyr Asp Xaa Phe 
        275                 280                 285             


Lys Gly Asp Asp Tyr Asn Glu Glu Asn Pro Xaa Glu Pro Gly Ser Asp 
    290                 295                 300                 


Gly Xaa Met Ser Asp Lys Glu Ile Xaa His Asp Val Lys Ala Val Cys 
305                 310                 315                 320 


Ser Gln Glu Ala Met Xaa Gly Pro Cys Arg Ala Val Met Pro Arg Trp 
                325                 330                 335     


Tyr Phe Asp Leu Ser Lys Gly Lys Cys Val Arg Phe Ile Tyr Gly Gly 
            340                 345                 350         


Cys Gly Gly Asn Arg Asn Asn Phe Glu Ser Glu Asp Tyr Cys Met Ala 
        355                 360                 365             


Val Cys Lys Ala Met Ile Pro Pro Xaa Pro Leu Pro Xaa Asn Asp Val 
    370                 375                 380                 


Asp Val Tyr Phe Glu Xaa Ser Ala Asp Asp Asn Glu His Ala Arg Phe 
385                 390                 395                 400 


Gln Lys Ala Lys Glu Gln Leu Glu Ile Arg His Arg Asn Arg Met Asp 
                405                 410                 415     


Arg Val Lys Lys Glu Trp Glu Glu Ala Glu Leu Gln Ala Lys Asn Leu 
            420                 425                 430         


Pro Lys Ala Glu Arg Gln Xaa Leu Ile Gln His Phe Gln Ala Met Val 
        435                 440                 445             


Lys Ala Leu Glu Lys Glu Ala Ala Ser Glu Lys Gln Gln Leu Val Glu 
    450                 455                 460                 


Xaa His Leu Ala Arg Val Glu Ala Met Leu Asn Asp Arg Arg Arg Met 
465                 470                 475                 480 


Ala Leu Glu Asn Tyr Leu Ala Ala Leu Gln Ser Asp Pro Pro Arg Pro 
                485                 490                 495     


His Arg Ile Leu Gln Ala Leu Arg Arg Tyr Val Arg Ala Glu Asn Lys 
            500                 505                 510         


Asp Arg Leu His Xaa Ile Arg His Tyr Gln His Val Leu Ala Val Asp 
        515                 520                 525             


Pro Glu Lys Ala Ala Gln Met Lys Ser Gln Val Met Xaa His Leu His 
    530                 535                 540                 


Val Ile Glu Glu Arg Arg Asn Gln Ser Leu Ser Leu Leu Tyr Lys Val 
545                 550                 555                 560 


Pro Tyr Val Ala Gln Glu Ile Gln Glu Glu Ile Asp Glu Leu Leu Gln 
                565                 570                 575     


Glu Gln Arg Ala Asp Met Asp Gln Phe Xaa Ala Ser Ile Ser Glu Xaa 
            580                 585                 590         


Pro Val Asp Val Arg Val Ser Ser Glu Glu Ser Glu Glu Ile Pro Pro 
        595                 600                 605             


Phe His Pro Phe His Pro Phe Pro Ala Leu Pro Glu Asn Glu Gly Ser 
    610                 615                 620                 


Gly Val Gly Glu Gln Asp Gly Gly Leu Ile Gly Ala Glu Glu Lys Val 
625                 630                 635                 640 


Ile Asn Ser Lys Asn Lys Val Asp Glu Asn Met Val Ile Asp Glu Xaa 
                645                 650                 655     


Leu Asp Val Lys Glu Met Ile Phe Asn Ala Glu Arg Val Gly Gly Leu 
            660                 665                 670         


Glu Glu Glu Arg Glu Ser Val Gly Pro Leu Arg Glu Asp Phe Ser Leu 
        675                 680                 685             


Ser Ser Ser Ala Leu Ile Gly Leu Leu Val Ile Ala Val Ala Ile Ala 
    690                 695                 700                 


Xaa Val Ile Val Ile Ser Leu Val Met Leu Arg Lys Arg Gln Tyr Gly 
705                 710                 715                 720 


Xaa Ile Ser His Gly Ile Val Glu Val Asp Pro Met Leu Xaa Pro Glu 
                725                 730                 735     


Glu Arg His Leu Asn Lys Met Gln Asn His Gly Tyr Glu Asn Pro Xaa 
            740                 745                 750         


Tyr Lys Tyr Leu Glu Gln Met Gln Ile 
        755                 760     


<210> 2581
<211> 267
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<400> 2581
Met Lys Ala Ala Val Leu Xaa Leu Ala Val Leu Phe Leu Xaa Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Xaa Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Xaa Ser Xaa 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Xaa Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Xaa Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Xaa His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Xaa Glu His Leu 
    210                 215                 220                 


Ser Xaa Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Xaa Lys Lys Leu Asn Xaa Gln 
            260                 265         


<210> 2582
<211> 245
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<400> 2582
Met Ser Gly Gly Ala Arg Gly Phe Cys Met Leu Lys Ala Pro His Ser 
1               5                   10                  15      


Ala Arg Pro Phe Phe Ser Ser Arg Ser Pro Xaa Ala Leu Gln Asp Glu 
            20                  25                  30          


Ser Cys Gly Ala Asp Leu Gly Arg Ala Leu Pro Asp Gly Leu Lys Leu 
        35                  40                  45              


Leu Asp Asn Trp Asp Ser Val Xaa Ser Xaa Phe Ser Lys Leu Arg Glu 
    50                  55                  60                  


Gln Leu Gly Pro Val Xaa Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu 
65                  70                  75                  80  


Xaa Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys 
                85                  90                  95      


Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu 
            100                 105                 110         


Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu 
        115                 120                 125             


Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser 
    130                 135                 140                 


Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala 
145                 150                 155                 160 


Leu Arg Xaa His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu 
                165                 170                 175     


Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala 
            180                 185                 190         


Glu Tyr His Ala Lys Ala Xaa Glu His Leu Ser Xaa Leu Ser Glu Lys 
        195                 200                 205             


Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu 
    210                 215                 220                 


Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Xaa Lys 
225                 230                 235                 240 


Lys Leu Asn Xaa Gln 
                245 


<210> 2583
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<400> 2583
Met Gly Xaa Trp Gly Ala Pro His Arg Xaa Leu Pro Cys Arg Asn Arg 
1               5                   10                  15      


Gly Ala Met Gln Pro Arg Val Leu Leu Val Val Ala Leu Leu Ala Leu 
            20                  25                  30          


Leu Ala Ser Ala Arg Ala Ser Glu Ala Glu Asp Ala Ser Leu Leu Ser 
        35                  40                  45              


Phe Met Gln Gly Tyr Met Lys His Ala Xaa Lys Xaa Ala Lys Asp Ala 
    50                  55                  60                  


Leu Ser Ser Val Gln Glu Ser Gln Val Ala Gln Gln Ala Arg Gly Trp 
65                  70                  75                  80  


Val Xaa Asp Gly Phe Ser Ser Leu Lys Asp Tyr Trp Ser Xaa Val Lys 
                85                  90                  95      


Asp Lys Phe Ser Glu Phe Trp Asp Leu Asp Pro Glu Val Arg Pro Xaa 
            100                 105                 110         


Ser Ala Val Ala Ala 
        115         


<210> 2584
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<400> 2584
Met Gln Pro Arg Val Leu Leu Val Val Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ser Ala Arg Ala Ser Glu Ala Glu Asp Ala Ser Leu Leu Ser Phe Met 
            20                  25                  30          


Gln Gly Tyr Met Lys His Ala Xaa Lys Xaa Ala Lys Asp Ala Leu Ser 
        35                  40                  45              


Ser Val Gln Glu Ser Gln Val 
    50                  55  


<210> 2585
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<400> 2585
Met Gln Pro Arg Val Leu Leu Val Val Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ser Ala Arg Ala Ser Glu Ala Glu Asp Ala Ser Leu Leu Ser Phe Met 
            20                  25                  30          


Gln Gly Tyr Met Lys His Ala Xaa Lys Xaa Ala Lys Asp Ala Leu Ser 
        35                  40                  45              


Ser Val Gln Glu Ser Gln Val Ala Gln Gln Ala Arg Gly Trp Val Xaa 
    50                  55                  60                  


Asp Gly Phe Ser Ser Leu Lys Asp Tyr Trp Ser Xaa Val Lys Asp Lys 
65                  70                  75                  80  


Phe Ser Glu Phe Trp Asp Leu Asp Pro Glu Val Arg Pro Xaa Ser Ala 
                85                  90                  95      


Val Ala Ala 
            


<210> 2586
<211> 215
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (82)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<400> 2586
Met Phe Lys Gln Leu Ser Cys Ile Ser Leu Pro Ser Ser Cys Asp Tyr 
1               5                   10                  15      


Ser Ser Arg Ser Leu Leu Gln Pro Pro Ser Pro Lys Met Val Met Leu 
            20                  25                  30          


Leu Leu Leu Leu Ser Ala Leu Ala Gly Leu Phe Gly Ala Ala Glu Gly 
        35                  40                  45              


Gln Ala Phe His Leu Gly Lys Cys Pro Asn Pro Pro Val Gln Glu Asn 
    50                  55                  60                  


Phe Asp Val Asn Lys Tyr Leu Gly Arg Trp Tyr Glu Ile Glu Lys Ile 
65                  70                  75                  80  


Pro Xaa Xaa Phe Glu Asn Gly Arg Cys Ile Gln Ala Asn Tyr Ser Leu 
                85                  90                  95      


Met Glu Asn Gly Lys Ile Lys Val Leu Asn Gln Glu Leu Arg Ala Asp 
            100                 105                 110         


Gly Xaa Val Asn Gln Ile Glu Gly Glu Ala Xaa Pro Val Asn Leu Xaa 
        115                 120                 125             


Glu Pro Ala Lys Leu Glu Val Lys Phe Ser Trp Phe Met Pro Ser Ala 
    130                 135                 140                 


Pro Tyr Trp Ile Leu Ala Xaa Asp Tyr Glu Asn Tyr Ala Leu Val Tyr 
145                 150                 155                 160 


Ser Cys Xaa Cys Ile Ile Gln Leu Phe His Val Asp Phe Ala Trp Ile 
                165                 170                 175     


Leu Ala Arg Asn Pro Asn Leu Pro Pro Glu Xaa Val Asp Ser Leu Lys 
            180                 185                 190         


Asn Ile Leu Xaa Ser Asn Asn Ile Asp Val Lys Lys Met Xaa Val Xaa 
        195                 200                 205             


Asp Gln Val Asn Cys Pro Lys 
    210                 215 


<210> 2587
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(107)
<223> Selenocysteine

<400> 2587
Met Val Met Leu Leu Leu Leu Leu Ser Ala Leu Ala Gly Leu Phe Gly 
1               5                   10                  15      


Ala Ala Glu Gly Gln Ala Phe His Leu Gly Lys Cys Pro Asn Pro Pro 
            20                  25                  30          


Val Gln Glu Asn Phe Asp Val Asn Lys Xaa Glu Ser His Phe Val Xaa 
        35                  40                  45              


Gln Gly Gly Val Gln His His His Leu Gly Ser Leu Gln Pro Pro Pro 
    50                  55                  60                  


Pro Gly Phe Lys Gln Phe Ser Cys Leu Ser Leu Pro Ser Ser Trp Asp 
65                  70                  75                  80  


Tyr Ser Ile Ser Glu Asp Gly Xaa Lys Leu Arg Arg Ser Gln Gln Pro 
                85                  90                  95      


Leu Arg Met Asp Ala Ala Ser Arg Pro Xaa Xaa His 
            100                 105             


<210> 2588
<211> 149
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<400> 2588
Met Val Met Leu Leu Leu Leu Leu Ser Ala Leu Ala Gly Leu Phe Gly 
1               5                   10                  15      


Ala Ala Glu Gly Gln Ala Phe His Leu Gly Lys Cys Pro Asn Pro Pro 
            20                  25                  30          


Val Gln Glu Asn Phe Asp Val Asn Lys Tyr Leu Gly Arg Trp Tyr Glu 
        35                  40                  45              


Ile Glu Lys Ile Pro Xaa Xaa Phe Glu Asn Gly Arg Cys Ile Gln Ala 
    50                  55                  60                  


Asn Tyr Ser Leu Met Glu Asn Gly Lys Ile Lys Val Leu Asn Gln Glu 
65                  70                  75                  80  


Leu Arg Ala Asp Gly Xaa Val Asn Gln Ile Glu Gly Glu Ala Xaa Pro 
                85                  90                  95      


Val Asn Leu Xaa Glu Pro Ala Lys Leu Glu Val Lys Phe Ser Trp Phe 
            100                 105                 110         


Met Pro Ser Ala Pro Tyr Trp Ile Leu Ala Xaa Asp Tyr Glu Asn Tyr 
        115                 120                 125             


Ala Leu Val Tyr Ser Cys Xaa Cys Ile Ile Gln Leu Phe His Val Asp 
    130                 135                 140                 


Phe Ala Trp Ile Leu 
145                 


<210> 2589
<211> 189
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<400> 2589
Met Val Met Leu Leu Leu Leu Leu Ser Ala Leu Ala Gly Leu Phe Gly 
1               5                   10                  15      


Ala Ala Glu Gly Gln Ala Phe His Leu Gly Lys Cys Pro Asn Pro Pro 
            20                  25                  30          


Val Gln Glu Asn Phe Asp Val Asn Lys Tyr Leu Gly Arg Trp Tyr Glu 
        35                  40                  45              


Ile Glu Lys Ile Pro Xaa Xaa Phe Glu Asn Gly Arg Cys Ile Gln Ala 
    50                  55                  60                  


Asn Tyr Ser Leu Met Glu Asn Gly Lys Ile Lys Val Leu Asn Gln Glu 
65                  70                  75                  80  


Leu Arg Ala Asp Gly Xaa Val Asn Gln Ile Glu Gly Glu Ala Xaa Pro 
                85                  90                  95      


Val Asn Leu Xaa Glu Pro Ala Lys Leu Glu Val Lys Phe Ser Trp Phe 
            100                 105                 110         


Met Pro Ser Ala Pro Tyr Trp Ile Leu Ala Xaa Asp Tyr Glu Asn Tyr 
        115                 120                 125             


Ala Leu Val Tyr Ser Cys Xaa Cys Ile Ile Gln Leu Phe His Val Asp 
    130                 135                 140                 


Phe Ala Trp Ile Leu Ala Arg Asn Pro Asn Leu Pro Pro Glu Xaa Val 
145                 150                 155                 160 


Asp Ser Leu Lys Asn Ile Leu Xaa Ser Asn Asn Ile Asp Val Lys Lys 
                165                 170                 175     


Met Xaa Val Xaa Asp Gln Val Asn Cys Pro Lys Leu Ser 
            180                 185                 


<210> 2590
<211> 216
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<400> 2590
Met Lys Val Leu Trp Ala Ala Leu Leu Val Xaa Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala Lys Val Glu Gln Ala Val Glu Xaa Glu Pro Glu Pro Glu Leu 
            20                  25                  30          


Arg Gln Gln Xaa Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
        35                  40                  45              


Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Xaa Leu Ser Glu Gln 
    50                  55                  60                  


Val Gln Glu Glu Leu Leu Ser Ser Gln Val Xaa Gln Glu Leu Arg Ala 
65                  70                  75                  80  


Leu Met Asp Glu Xaa Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                85                  90                  95      


Glu Glu Gln Leu Xaa Pro Val Ala Glu Glu Xaa Arg Ala Arg Leu Ser 
            100                 105                 110         


Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
        115                 120                 125             


Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 
    130                 135                 140                 


Gly Gln Ser Xaa Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 
                165                 170                 175     


Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 
            180                 185                 190         


Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 
        195                 200                 205             


Arg Ala Ala Xaa Val Gly Ser Leu 
    210                 215     


<210> 2591
<211> 219
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<400> 2591
Met Lys Val Leu Trp Ala Ala Leu Leu Val Xaa Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala Lys Val Glu Gln Ala Val Glu Xaa Glu Pro Glu Pro Glu Leu 
            20                  25                  30          


Arg Gln Gln Xaa Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
        35                  40                  45              


Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Xaa Leu Ser Glu Gln 
    50                  55                  60                  


Val Gln Glu Glu Leu Leu Ser Ser Gln Val Xaa Gln Glu Leu Arg Ala 
65                  70                  75                  80  


Leu Met Asp Glu Xaa Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                85                  90                  95      


Glu Glu Gln Leu Xaa Pro Val Ala Glu Glu Xaa Arg Ala Arg Leu Ser 
            100                 105                 110         


Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
        115                 120                 125             


Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 
    130                 135                 140                 


Gly Gln Ser Xaa Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 
                165                 170                 175     


Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 
            180                 185                 190         


Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 
        195                 200                 205             


Arg Ala Ala Xaa Val Gly Ser Leu Ala Gly Gln 
    210                 215                 


<210> 2592
<211> 317
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<400> 2592
Met Lys Val Leu Trp Ala Ala Leu Leu Val Xaa Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala Lys Val Glu Gln Ala Val Glu Xaa Glu Pro Glu Pro Glu Leu 
            20                  25                  30          


Arg Gln Gln Xaa Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
        35                  40                  45              


Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Xaa Leu Ser Glu Gln 
    50                  55                  60                  


Val Gln Glu Glu Leu Leu Ser Ser Gln Val Xaa Gln Glu Leu Arg Ala 
65                  70                  75                  80  


Leu Met Asp Glu Xaa Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                85                  90                  95      


Glu Glu Gln Leu Xaa Pro Val Ala Glu Glu Xaa Arg Ala Arg Leu Ser 
            100                 105                 110         


Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
        115                 120                 125             


Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 
    130                 135                 140                 


Gly Gln Ser Xaa Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 
                165                 170                 175     


Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 
            180                 185                 190         


Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 
        195                 200                 205             


Arg Ala Ala Xaa Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg 
    210                 215                 220                 


Ala Gln Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly 
225                 230                 235                 240 


Ser Arg Xaa Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu 
                245                 250                 255     


Val Arg Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala 
            260                 265                 270         


Glu Ala Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu 
        275                 280                 285             


Asp Met Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala 
    290                 295                 300                 


Val Gly Xaa Ser Ala Ala Pro Val Pro Ser Asp Asn His 
305                 310                 315         


<210> 2593
<211> 269
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<400> 2593
Met Ser Ser Gly Ala Ser Arg Lys Ser Trp Asp Pro Gly Asn Pro Trp 
1               5                   10                  15      


Pro Pro Asp Trp Pro Ile Xaa Gly Arg Lys Met Lys Val Leu Trp Ala 
            20                  25                  30          


Ala Leu Leu Val Xaa Phe Leu Ala Gly Cys Gln Ala Lys Val Glu Gln 
        35                  40                  45              


Ala Val Glu Xaa Glu Pro Glu Pro Glu Leu Arg Gln Gln Xaa Glu Trp 
    50                  55                  60                  


Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Trp Asp Tyr 
65                  70                  75                  80  


Leu Arg Trp Val Gln Xaa Leu Ser Glu Gln Val Gln Glu Glu Leu Leu 
                85                  90                  95      


Ser Ser Gln Val Xaa Gln Glu Leu Arg Ala Leu Met Asp Glu Xaa Met 
            100                 105                 110         


Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Xaa Pro 
        115                 120                 125             


Val Ala Glu Glu Xaa Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala 
    130                 135                 140                 


Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Cys Gly Arg Leu Val 
145                 150                 155                 160 


Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Xaa Glu Glu 
                165                 170                 175     


Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu Arg Lys Arg Leu 
            180                 185                 190         


Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala 
        195                 200                 205             


Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu Ser Ala Ile Arg Glu Arg 
    210                 215                 220                 


Leu Gly Pro Leu Val Glu Gln Gly Arg Val Arg Ala Ala Xaa Val Gly 
225                 230                 235                 240 


Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg Ala Gln Ala Trp Gly Glu 
                245                 250                 255     


Arg Leu Arg Ala Arg Met Glu Glu Met Gly Ser Arg Xaa 
            260                 265                 


<210> 2594
<211> 449
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<400> 2594
Met His Ser Trp Xaa Trp Asp Pro His Ser Ser Glu Gln Leu Asp Leu 
1               5                   10                  15      


Ala Gln Ser Leu Ser Glu Glu Asp Pro Leu Ser Ser Leu Arg Gly Ser 
            20                  25                  30          


Ile Gln Pro Gln Pro Pro Ala Glu Ala Pro Asp Lys Gly Gly Ser Gln 
        35                  40                  45              


Ala Asn Asn Asp Pro Gly Gly Trp Asp Pro Gly Cys Ser Ser Ser Gln 
    50                  55                  60                  


Val Leu Gly Arg Xaa Arg Gly Pro Cys Leu Gly Val Arg Val Arg Glu 
65                  70                  75                  80  


Glu Glu Ala Gly Xaa Arg Val Lys Glu Asn Leu Pro Val Trp Xaa Val 
                85                  90                  95      


Xaa Gly Glu Leu Gln Gly Lys Pro Leu Gly Asn Pro Ala Ala Gly Xaa 
            100                 105                 110         


Met Asn Pro Glu Ser Ser Ile Phe Ile Glu Asp Tyr Leu Lys Tyr Phe 
        115                 120                 125             


Gln Asp Gln Val Ser Arg Glu Asn Leu Leu Gln Leu Leu Xaa Asp Asp 
    130                 135                 140                 


Glu Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asp Glu 
145                 150                 155                 160 


Ala Asp Glu Leu Arg Lys Ala Leu Asn Lys Leu Ala Ser His Met Val 
                165                 170                 175     


Met Lys Asp Lys Asn Arg His Asp Lys Asp Gln Gln His Arg Gln Trp 
            180                 185                 190         


Phe Leu Lys Glu Phe Pro Arg Leu Lys Arg Glu Leu Glu Asp His Ile 
        195                 200                 205             


Arg Lys Leu Arg Ala Leu Ala Glu Glu Val Glu Gln Val His Arg Gly 
    210                 215                 220                 


Xaa Xaa Ile Ala Asn Val Val Ser Asn Ser Val Gly Xaa Xaa Ser Gly 
225                 230                 235                 240 


Ile Leu Xaa Leu Leu Gly Leu Gly Leu Ala Pro Phe Xaa Glu Gly Ile 
                245                 250                 255     


Ser Phe Val Leu Leu Asp Xaa Gly Met Gly Leu Gly Ala Ala Ala Ala 
            260                 265                 270         


Val Ala Gly Ile Xaa Cys Ser Val Val Glu Leu Val Asn Lys Leu Arg 
        275                 280                 285             


Ala Arg Ala Gln Ala Arg Asn Leu Asp Gln Ser Gly Xaa Asn Val Ala 
    290                 295                 300                 


Lys Val Met Lys Glu Phe Val Gly Gly Asn Xaa Pro Asn Val Leu Xaa 
305                 310                 315                 320 


Leu Val Asp Asn Trp Tyr Gln Val Xaa Gln Gly Ile Gly Arg Asn Ile 
                325                 330                 335     


Arg Ala Ile Arg Arg Ala Arg Ala Asn Pro Gln Leu Gly Ala Tyr Ala 
            340                 345                 350         


Pro Pro Pro His Val Ile Gly Arg Ile Ser Ala Glu Gly Gly Glu Gln 
        355                 360                 365             


Val Glu Arg Val Val Glu Gly Pro Ala Gln Ala Met Ser Arg Gly Xaa 
    370                 375                 380                 


Met Ile Val Gly Ala Ala Xaa Gly Gly Ile Leu Leu Leu Leu Asp Val 
385                 390                 395                 400 


Val Ser Leu Ala Tyr Glu Ser Lys His Leu Leu Glu Gly Ala Lys Ser 
                405                 410                 415     


Glu Ser Ala Glu Glu Leu Lys Lys Arg Ala Gln Glu Leu Glu Gly Lys 
            420                 425                 430         


Leu Asn Phe Leu Xaa Lys Ile His Glu Met Leu Gln Pro Gly Gln Asp 
        435                 440                 445             


Gln 
    


<210> 2595
<211> 74
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<400> 2595
Met Asn Pro Glu Ser Ser Ile Phe Ile Glu Asp Tyr Leu Lys Tyr Phe 
1               5                   10                  15      


Gln Asp Gln Val Ser Arg Glu Asn Leu Leu Gln Leu Leu Xaa Asp Asp 
            20                  25                  30          


Glu Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asp Glu 
        35                  40                  45              


Ala Asp Glu Leu Arg Lys Ala Leu Asn Lys Leu Ala Ser His Met Val 
    50                  55                  60                  


Met Lys Asp Lys Asn Arg His Asp Lys Asp 
65                  70                  


<210> 2596
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(126)
<223> Selenocysteine

<400> 2596
Met Asn Pro Glu Ser Ser Ile Phe Ile Glu Asp Tyr Leu Lys Tyr Phe 
1               5                   10                  15      


Gln Asp Gln Val Ser Arg Glu Asn Leu Leu Gln Leu Leu Xaa Asp Asp 
            20                  25                  30          


Glu Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asp Glu 
        35                  40                  45              


Ala Asp Glu Leu Arg Lys Ala Leu Asn Lys Leu Ala Ser His Met Val 
    50                  55                  60                  


Met Lys Asp Lys Asn Arg His Asp Lys Asp Gln Gln His Arg Gln Trp 
65                  70                  75                  80  


Phe Leu Lys Glu Phe Pro Arg Leu Lys Arg Glu Leu Glu Asp His Ile 
                85                  90                  95      


Arg Lys Leu Arg Ala Leu Ala Glu Glu Val Glu Gln Val His Arg Gly 
            100                 105                 110         


Xaa Xaa Ile Ala Asn Val Val Ser Asn Ser Val Gly Xaa Xaa Ser Gly 
        115                 120                 125             


<210> 2597
<211> 337
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<400> 2597
Met Asn Pro Glu Ser Ser Ile Phe Ile Glu Asp Tyr Leu Lys Tyr Phe 
1               5                   10                  15      


Gln Asp Gln Val Ser Arg Glu Asn Leu Leu Gln Leu Leu Xaa Asp Asp 
            20                  25                  30          


Glu Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asp Glu 
        35                  40                  45              


Ala Asp Glu Leu Arg Lys Ala Leu Asn Lys Leu Ala Ser His Met Val 
    50                  55                  60                  


Met Lys Asp Lys Asn Arg His Asp Lys Asp Gln Gln His Arg Gln Trp 
65                  70                  75                  80  


Phe Leu Lys Glu Phe Pro Arg Leu Lys Arg Glu Leu Glu Asp His Ile 
                85                  90                  95      


Arg Lys Leu Arg Ala Leu Ala Glu Glu Val Glu Gln Val His Arg Gly 
            100                 105                 110         


Xaa Xaa Ile Ala Asn Val Val Ser Asn Ser Val Gly Xaa Xaa Ser Gly 
        115                 120                 125             


Ile Leu Xaa Leu Leu Gly Leu Gly Leu Ala Pro Phe Xaa Glu Gly Ile 
    130                 135                 140                 


Ser Phe Val Leu Leu Asp Xaa Gly Met Gly Leu Gly Ala Ala Ala Ala 
145                 150                 155                 160 


Val Ala Gly Ile Xaa Cys Ser Val Val Glu Leu Val Asn Lys Leu Arg 
                165                 170                 175     


Ala Arg Ala Gln Ala Arg Asn Leu Asp Gln Ser Gly Xaa Asn Val Ala 
            180                 185                 190         


Lys Val Met Lys Glu Phe Val Gly Gly Asn Xaa Pro Asn Val Leu Xaa 
        195                 200                 205             


Leu Val Asp Asn Trp Tyr Gln Val Xaa Gln Gly Ile Gly Arg Asn Ile 
    210                 215                 220                 


Arg Ala Ile Arg Arg Ala Arg Ala Asn Pro Gln Leu Gly Ala Tyr Ala 
225                 230                 235                 240 


Pro Pro Pro His Val Ile Gly Arg Ile Ser Ala Glu Gly Gly Glu Gln 
                245                 250                 255     


Val Glu Arg Val Val Glu Gly Pro Ala Gln Ala Met Ser Arg Gly Xaa 
            260                 265                 270         


Met Ile Val Gly Ala Ala Xaa Gly Gly Ile Leu Leu Leu Leu Asp Val 
        275                 280                 285             


Val Ser Leu Ala Tyr Glu Ser Lys His Leu Leu Glu Gly Ala Lys Ser 
    290                 295                 300                 


Glu Ser Ala Glu Glu Leu Lys Lys Arg Ala Gln Glu Leu Glu Gly Lys 
305                 310                 315                 320 


Leu Asn Phe Leu Xaa Lys Ile His Glu Met Leu Gln Pro Gly Gln Asp 
                325                 330                 335     


Gln 
    


<210> 2598
<211> 331
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<400> 2598
Met Asp Ser Glu Lys Lys Arg Phe Xaa Glu Glu Ala Xaa Lys Tyr Phe 
1               5                   10                  15      


Arg Glu Arg Val Ser Pro Val His Leu Gln Ile Leu Leu Xaa Asn Asn 
            20                  25                  30          


Glu Ala Trp Lys Arg Phe Val Xaa Ala Ala Glu Leu Pro Arg Asp Glu 
        35                  40                  45              


Ala Asp Ala Leu Tyr Glu Ala Leu Lys Lys Leu Arg Xaa Tyr Ala Ala 
    50                  55                  60                  


Ile Glu Asp Glu Tyr Val Gln Gln Lys Asp Glu Gln Phe Arg Glu Trp 
65                  70                  75                  80  


Phe Leu Lys Glu Phe Pro Gln Val Lys Arg Lys Ile Gln Glu Ser Ile 
                85                  90                  95      


Glu Lys Leu Arg Ala Leu Ala Asn Gly Ile Glu Glu Val His Arg Gly 
            100                 105                 110         


Cys Xaa Ile Ser Asn Val Val Ser Ser Ser Xaa Gly Ala Ala Ser Gly 
        115                 120                 125             


Ile Met Ser Leu Ala Gly Leu Val Leu Ala Pro Phe Xaa Ala Gly Xaa 
    130                 135                 140                 


Ser Leu Ala Leu Xaa Ala Ala Gly Val Gly Leu Gly Ala Ala Ser Ala 
145                 150                 155                 160 


Val Xaa Gly Ile Xaa Xaa Ser Ile Val Glu His Ser Tyr Xaa Ser Ser 
                165                 170                 175     


Ala Glu Ala Glu Ala Ser Arg Leu Xaa Ala Xaa Ser Ile Asp Arg Leu 
            180                 185                 190         


Lys Val Phe Lys Glu Val Met Arg Asp Ile Xaa Pro Asn Leu Leu Ser 
        195                 200                 205             


Leu Leu Asn Asn Tyr Tyr Glu Ala Xaa Gln Xaa Ile Gly Ser Glu Ile 
    210                 215                 220                 


Arg Ala Ile Arg Gln Ala Arg Ala Arg Ala Arg Leu Pro Val Xaa Xaa 
225                 230                 235                 240 


Trp Arg Ile Ser Ala Gly Ser Gly Gly Gln Ala Glu Arg Xaa Ile Ala 
                245                 250                 255     


Gly Xaa Xaa Arg Ala Val Ser Arg Gly Ala Arg Ile Leu Ser Ala Xaa 
            260                 265                 270         


Xaa Ser Gly Ile Phe Leu Ala Leu Asp Val Val Asn Leu Val Tyr Glu 
        275                 280                 285             


Ser Lys His Leu His Glu Gly Ala Lys Ser Ala Ser Ala Glu Glu Leu 
    290                 295                 300                 


Arg Arg Gln Ala Gln Glu Leu Glu Glu Asn Leu Met Glu Leu Xaa Gln 
305                 310                 315                 320 


Ile Tyr Gln Arg Leu Asn Pro Cys His Xaa His 
                325                 330     


<210> 2599
<211> 402
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<400> 2599
Met Gly Leu Gly Gln Gly Trp Gly Trp Glu Ala Ser Cys Phe Ala Cys 
1               5                   10                  15      


Leu Ile Arg Ser Cys Cys Gln Val Val Xaa Phe Xaa Phe Pro Phe Gly 
            20                  25                  30          


Phe Gln Gly Ile Ser Gln Ser Leu Glu Asn Val Ser Gly Tyr Tyr Ala 
        35                  40                  45              


Asp Ala Arg Leu Glu Val Gly Ser Xaa Gln Leu Arg Xaa Ala Gly Ser 
    50                  55                  60                  


Cys Ser His Ser Phe Lys Arg Ser Phe Leu Glu Lys Lys Arg Phe Xaa 
65                  70                  75                  80  


Glu Glu Ala Xaa Lys Tyr Phe Arg Glu Arg Val Ser Pro Val His Leu 
                85                  90                  95      


Gln Ile Leu Leu Xaa Asn Asn Glu Ala Trp Lys Arg Phe Val Xaa Ala 
            100                 105                 110         


Ala Glu Leu Pro Arg Asp Glu Ala Asp Ala Leu Tyr Glu Ala Leu Lys 
        115                 120                 125             


Lys Leu Arg Xaa Tyr Ala Ala Ile Glu Asp Glu Tyr Val Gln Gln Lys 
    130                 135                 140                 


Asp Glu Gln Phe Arg Glu Trp Phe Leu Lys Glu Phe Pro Gln Val Lys 
145                 150                 155                 160 


Arg Lys Ile Gln Glu Ser Ile Glu Lys Leu Arg Ala Leu Ala Asn Gly 
                165                 170                 175     


Ile Glu Glu Val His Arg Gly Cys Xaa Ile Ser Asn Val Val Ser Ser 
            180                 185                 190         


Ser Xaa Gly Ala Ala Ser Gly Ile Met Ser Leu Ala Gly Leu Val Leu 
        195                 200                 205             


Ala Pro Phe Xaa Ala Gly Xaa Ser Leu Ala Leu Xaa Ala Ala Gly Val 
    210                 215                 220                 


Gly Leu Gly Ala Ala Ser Ala Val Xaa Gly Ile Xaa Xaa Ser Ile Val 
225                 230                 235                 240 


Glu His Ser Tyr Xaa Ser Ser Ala Glu Ala Glu Ala Ser Arg Leu Xaa 
                245                 250                 255     


Ala Xaa Ser Ile Asp Arg Leu Lys Val Phe Lys Glu Val Met Arg Asp 
            260                 265                 270         


Ile Xaa Pro Asn Leu Leu Ser Leu Leu Asn Asn Tyr Tyr Glu Ala Xaa 
        275                 280                 285             


Gln Xaa Ile Gly Ser Glu Ile Arg Ala Ile Arg Gln Ala Arg Ala Arg 
    290                 295                 300                 


Ala Arg Leu Pro Val Xaa Xaa Trp Arg Ile Ser Ala Gly Ser Gly Gly 
305                 310                 315                 320 


Gln Ala Glu Arg Xaa Ile Ala Gly Xaa Xaa Arg Ala Val Ser Arg Gly 
                325                 330                 335     


Ala Arg Ile Leu Ser Ala Xaa Xaa Ser Gly Ile Phe Leu Ala Leu Asp 
            340                 345                 350         


Val Val Asn Leu Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys 
        355                 360                 365             


Ser Ala Ser Ala Glu Glu Leu Arg Arg Gln Ala Gln Glu Leu Glu Glu 
    370                 375                 380                 


Asn Leu Met Glu Leu Xaa Gln Ile Tyr Gln Arg Leu Asn Pro Cys His 
385                 390                 395                 400 


Xaa His 
        


<210> 2600
<211> 97
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 2600
Met Gly Leu Gly Gln Gly Trp Gly Trp Glu Ala Ser Cys Phe Ala Cys 
1               5                   10                  15      


Leu Ile Arg Ser Cys Cys Gln Val Val Xaa Phe Xaa Phe Pro Phe Gly 
            20                  25                  30          


Phe Gln Gly Ile Ser Gln Ser Leu Glu Asn Val Ser Gly Tyr Tyr Ala 
        35                  40                  45              


Asp Ala Arg Leu Glu Val Gly Ser Xaa Gln Leu Arg Xaa Ala Gly Ser 
    50                  55                  60                  


Cys Ser His Ser Phe Lys Arg Ser Phe Leu Gly Leu Arg Lys Lys Xaa 
65                  70                  75                  80  


Asn Pro Ser Ser Gln Val Ser Asp Trp Arg Ala Pro Trp Lys Val Ser 
                85                  90                  95      


Gln 
    


<210> 2601
<211> 82
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<400> 2601
Met Gly Leu Gly Gln Gly Trp Gly Trp Glu Ala Ser Cys Phe Ala Cys 
1               5                   10                  15      


Leu Ile Arg Ser Cys Cys Gln Val Val Xaa Phe Xaa Phe Pro Phe Gly 
            20                  25                  30          


Phe Gln Gly Ile Ser Gln Ser Leu Glu Asn Val Ser Gly Tyr Tyr Ala 
        35                  40                  45              


Asp Ala Arg Leu Glu Val Gly Ser Xaa Gln Leu Arg Xaa Ala Gly Ser 
    50                  55                  60                  


Cys Ser His Ser Phe Lys Arg Ser Phe Leu Gly Gln Lys Asp Pro Ala 
65                  70                  75                  80  


Leu Val 
        


<210> 2602
<211> 202
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<400> 2602
Met Ser Leu Ala Gly Leu Val Leu Ala Pro Phe Xaa Ala Gly Xaa Ser 
1               5                   10                  15      


Leu Ala Leu Xaa Ala Ala Gly Val Gly Leu Gly Ala Ala Ser Ala Val 
            20                  25                  30          


Xaa Gly Ile Xaa Xaa Ser Ile Val Glu His Ser Tyr Xaa Ser Ser Ala 
        35                  40                  45              


Glu Ala Glu Ala Ser Arg Leu Xaa Ala Xaa Ser Ile Asp Arg Leu Lys 
    50                  55                  60                  


Val Phe Lys Glu Val Met Arg Asp Ile Xaa Pro Asn Leu Leu Ser Leu 
65                  70                  75                  80  


Leu Asn Asn Tyr Tyr Glu Ala Xaa Gln Xaa Ile Gly Ser Glu Ile Arg 
                85                  90                  95      


Ala Ile Arg Gln Ala Arg Ala Arg Ala Arg Leu Pro Val Xaa Xaa Trp 
            100                 105                 110         


Arg Ile Ser Ala Gly Ser Gly Gly Gln Ala Glu Arg Xaa Ile Ala Gly 
        115                 120                 125             


Xaa Xaa Arg Ala Val Ser Arg Gly Ala Arg Ile Leu Ser Ala Xaa Xaa 
    130                 135                 140                 


Ser Gly Ile Phe Leu Ala Leu Asp Val Val Asn Leu Val Tyr Glu Ser 
145                 150                 155                 160 


Lys His Leu His Glu Gly Ala Lys Ser Ala Ser Ala Glu Glu Leu Arg 
                165                 170                 175     


Arg Gln Ala Gln Glu Leu Glu Glu Asn Leu Met Glu Leu Xaa Gln Ile 
            180                 185                 190         


Tyr Gln Arg Leu Asn Pro Cys His Xaa His 
        195                 200         


<210> 2603
<211> 40
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<400> 2603
Ser Gln Ser Leu Glu Asn Val Ser Gly Tyr Tyr Ala Asp Ala Arg Leu 
1               5                   10                  15      


Glu Val Gly Ser Xaa Gln Leu Arg Xaa Ala Gly Ser Cys Ser His Ser 
            20                  25                  30          


Phe Lys Arg Ser Phe Leu Gly Glu 
        35                  40  


<210> 2604
<211> 39
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<400> 2604
Xaa Tyr Ala Asp Ala Arg Leu Glu Val Gly Ser Xaa Gln Leu Arg Xaa 
1               5                   10                  15      


Ala Gly Ser Cys Ser His Ser Phe Lys Arg Ser Phe Leu Ala Trp Leu 
            20                  25                  30          


Pro Gln Pro Pro Arg Phe Leu 
        35                  


<210> 2605
<211> 86
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<400> 2605
Xaa Tyr Ala Asp Ala Arg Leu Glu Val Gly Ser Xaa Gln Leu Arg Xaa 
1               5                   10                  15      


Ala Gly Ser Cys Ser His Ser Phe Lys Arg Ser Phe Leu Ala Trp Trp 
            20                  25                  30          


Tyr Val Pro Val Gly Xaa Xaa Xaa Trp Glu Val Glu Ala Glu Ala Ser 
        35                  40                  45              


Leu Ala Ala Arg Xaa Tyr Arg Gln Lys Gln Gly Gly Gln Arg Val Ser 
    50                  55                  60                  


Ser Xaa Ala Pro Val Asn Ser Pro Arg Gln Xaa Leu Gly His Arg Val 
65                  70                  75                  80  


Gln Asp Xaa Asp Leu Glu 
                85      


<210> 2606
<211> 33
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<400> 2606
Xaa Tyr Ala Asp Ala Arg Leu Glu Val Gly Ser Xaa Gln Leu Arg Xaa 
1               5                   10                  15      


Ala Gly Ser Cys Ser His Ser Phe Lys Arg Ser Phe Leu Glu Met Ser 
            20                  25                  30          


Ile 
    


<210> 2607
<211> 52
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<400> 2607
Xaa Tyr Ala Asp Ala Arg Leu Glu Val Gly Ser Xaa Gln Leu Arg Xaa 
1               5                   10                  15      


Ala Gly Ser Cys Ser His Ser Phe Lys Arg Ser Phe Leu Gly Leu Arg 
            20                  25                  30          


Lys Lys Xaa Asn Pro Ser Ser Gln Val Ser Asp Trp Arg Ala Pro Trp 
        35                  40                  45              


Lys Val Ser Gln 
    50          


<210> 2608
<211> 37
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<400> 2608
Xaa Tyr Ala Asp Ala Arg Leu Glu Val Gly Ser Xaa Gln Leu Arg Xaa 
1               5                   10                  15      


Ala Gly Ser Cys Ser His Ser Phe Lys Arg Ser Phe Leu Gly Gln Lys 
            20                  25                  30          


Asp Pro Ala Leu Val 
        35          


<210> 2609
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<400> 2609
Ala Ala Val Arg Arg Gly Ser Gln Gly Ala Trp Gly His Gly Gly Leu 
1               5                   10                  15      


Ala Gly Gly Glu Glu Asp Leu Ser Pro Pro Ser Leu Pro Arg Leu Arg 
            20                  25                  30          


Leu Pro Arg Leu Ser Xaa Arg Ser Gly Ala Arg Arg Arg Ala Gln Gly 
        35                  40                  45              


Tyr Gly Ala Gln Arg Gly Gln Lys Ala Xaa Leu Asn Ala Glu Glu Met 
    50                  55                  60                  


Ala Asp Phe Tyr Lys Glu Phe Leu Ser Lys Asn Phe Gln Lys His Met 
65                  70                  75                  80  


Tyr Tyr Asn Arg Asp Trp Tyr Lys Arg Asn Phe Ala Ile Xaa Phe Phe 
                85                  90                  95      


Met Gly Lys Val Ala Leu Glu Arg Ile Trp Asn Lys Leu Lys Gln Lys 
            100                 105                 110         


Gln Lys Lys Arg Ser Asn 
        115             


<210> 2610
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 2610
Ala Phe Ala Cys Arg Gly Cys Gln Leu Ala Pro Glu Arg Gly Ala Glu 
1               5                   10                  15      


Arg Arg Asp Xaa Ala Pro Ser Gly Pro Pro Gln Ala Phe Val Gln Val 
            20                  25                  30          


Leu Ser Arg Pro Ile Pro Asn Ser Pro Ala Ala Pro Arg Leu Pro His 
        35                  40                  45              


Gln Arg Pro Gln Ser Asp Gly Xaa Glu Gly Ala Ala Ala Xaa Xaa Pro 
    50                  55                  60                  


Gly Xaa Val Asp Ser Gln Asn Leu 
65                  70          


<210> 2611
<211> 132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<400> 2611
Gly Pro Pro Asp Lys Tyr Ser Asn Leu Arg Pro Val His Phe Tyr Ile 
1               5                   10                  15      


Pro Glu Asn Glu Ser Pro Leu Glu Gln Lys Leu Arg Lys Leu Arg Gln 
            20                  25                  30          


Glu Xaa Gln Glu Trp Asn Gln Gln Phe Trp Ala Asn Gln Asn Leu Xaa 
        35                  40                  45              


Phe Ser Lys Glu Lys Glu Glu Phe Ile His Ser Arg Leu Lys Xaa Lys 
    50                  55                  60                  


Gly Leu Gly Leu Arg Xaa Glu Ser Asp Gly Val Ser Leu Cys His Pro 
65                  70                  75                  80  


Gly Trp Ser Ala Val Ala Arg Ser Arg Leu Xaa Ala Asn Ser Ala Ser 
                85                  90                  95      


Trp Phe Lys Arg Phe Ser Cys Leu Ser Leu Leu Ser Ser Trp Asp Tyr 
            100                 105                 110         


Arg Ser Glu Ser Asn Ile Glu Cys Arg Arg Asn Gly Gly Leu Leu Gln 
        115                 120                 125             


Gly Ile Phe Lys 
    130         


<210> 2612
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<400> 2612
Leu Ala Pro Glu Arg Gly Ala Glu Arg Arg Asp Xaa Ala Pro Ser Gly 
1               5                   10                  15      


Val Ser Arg Phe Cys Pro Pro Arg Lys Ser Cys His Asp Trp Ile Gly 
            20                  25                  30          


Pro Pro Asp Lys Tyr Ser Asn Leu Arg Pro Val His Phe Tyr Ile Pro 
        35                  40                  45              


Glu Asn Glu Ser Pro Leu Glu Gln Lys Leu Arg Lys Leu Arg Gln Glu 
    50                  55                  60                  


Xaa Gln Glu Trp Asn Gln Gln Phe Trp Ala Asn Gln Asn Leu Xaa Phe 
65                  70                  75                  80  


Ser Lys Glu Lys Glu Glu Phe Ile His Ser Arg Leu Lys Xaa Lys Gly 
                85                  90                  95      


Leu Gly Leu Arg Xaa Glu Ser Gly Gly Tyr Asp Gly 
            100                 105             


<210> 2613
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<400> 2613
Met Ala Asp Phe Tyr Lys Glu Phe Leu Ser Lys Asn Phe Gln Lys His 
1               5                   10                  15      


Met Tyr Tyr Asn Arg Asp Trp Tyr Lys Arg Asn Phe Ala Ile Xaa Phe 
            20                  25                  30          


Phe Met Gly Lys Val Ala Leu Glu Arg Ile Trp Asn Lys Leu Lys Gln 
        35                  40                  45              


Lys Gln Lys Lys Arg Ser Asn 
    50                  55  


<210> 2614
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<400> 2614
Met Ala Asp Phe Tyr Lys Glu Phe Leu Ser Lys Asn Phe Gln Lys His 
1               5                   10                  15      


Met Tyr Tyr Asn Arg Leu Asp Xaa Val Ala Arg Xaa Trp Asn Pro Met 
            20                  25                  30          


Xaa Leu Gly Gly Gln Glu Ile Gly Xaa Ser Ala Ile Leu Pro Ser Pro 
        35                  40                  45              


Ser Ser Trp Glu Lys Trp Pro Trp Lys Gly Phe Gly Xaa Ser Leu Asn 
    50                  55                  60                  


Arg Asn Lys Arg Arg Gly Ala Xaa Arg Ser Pro Leu 
65                  70                  75      


<210> 2615
<211> 206
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<400> 2615
Met Leu Pro Cys Ala Ala Gly Ala Arg Gly Arg Gly Ala Met Val Val 
1               5                   10                  15      


Leu Arg Ala Gly Lys Lys Xaa Phe Leu Pro Pro Leu Cys Arg Ala Phe 
            20                  25                  30          


Ala Cys Arg Gly Cys Gln Leu Ala Pro Glu Arg Gly Ala Glu Arg Arg 
        35                  40                  45              


Asp Xaa Ala Pro Ser Gly Val Ser Arg Phe Cys Pro Pro Arg Lys Ser 
    50                  55                  60                  


Cys His Asp Trp Ile Gly Pro Pro Asp Lys Tyr Ser Asn Leu Arg Pro 
65                  70                  75                  80  


Val His Phe Tyr Ile Pro Glu Asn Glu Ser Pro Leu Glu Gln Lys Leu 
                85                  90                  95      


Arg Lys Leu Arg Gln Glu Xaa Gln Glu Trp Asn Gln Gln Phe Trp Ala 
            100                 105                 110         


Asn Gln Asn Leu Xaa Phe Ser Lys Glu Lys Glu Glu Phe Ile His Ser 
        115                 120                 125             


Arg Leu Lys Xaa Lys Gly Leu Gly Leu Arg Xaa Glu Ser Gly Gln Lys 
    130                 135                 140                 


Ala Xaa Leu Asn Ala Glu Glu Met Ala Asp Phe Tyr Lys Glu Phe Leu 
145                 150                 155                 160 


Ser Lys Asn Phe Gln Lys His Met Tyr Tyr Asn Arg Asp Trp Tyr Lys 
                165                 170                 175     


Arg Asn Phe Ala Ile Xaa Phe Phe Met Gly Lys Val Ala Leu Glu Arg 
            180                 185                 190         


Ile Trp Asn Lys Leu Lys Gln Lys Gln Lys Lys Arg Ser Asn 
        195                 200                 205     


<210> 2616
<211> 177
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<400> 2616
Met Val Val Leu Arg Ala Gly Lys Lys Xaa Phe Leu Pro Pro Leu Cys 
1               5                   10                  15      


Arg Ala Phe Ala Cys Arg Gly Cys Gln Leu Ala Pro Glu Arg Gly Ala 
            20                  25                  30          


Glu Arg Arg Asp Xaa Ala Pro Ser Gly Val Ser Arg Phe Cys Pro Pro 
        35                  40                  45              


Arg Lys Ser Cys His Asp Trp Ile Gly Pro Pro Asp Lys Tyr Ser Asn 
    50                  55                  60                  


Leu Arg Pro Val His Phe Tyr Ile Pro Glu Asn Glu Ser Pro Leu Glu 
65                  70                  75                  80  


Gln Lys Leu Arg Lys Leu Arg Gln Glu Xaa Gln Glu Trp Asn Gln Gln 
                85                  90                  95      


Phe Trp Ala Asn Gln Asn Leu Xaa Phe Ser Lys Glu Lys Glu Glu Phe 
            100                 105                 110         


Ile His Ser Arg Leu Lys Xaa Lys Gly Leu Gly Leu Arg Xaa Glu Ser 
        115                 120                 125             


Asp Pro Xaa Leu Pro Arg Val Xaa Glu Xaa Met Glu Arg Lys Xaa Met 
    130                 135                 140                 


Asp Gly Gly Asp Ser Cys Ala Ala Ala Ile Ser Leu Xaa Gln Ser Glu 
145                 150                 155                 160 


Ser Asn Ile Glu Cys Arg Arg Asn Gly Gly Leu Leu Gln Gly Ile Phe 
                165                 170                 175     


Lys 
    


<210> 2617
<211> 120
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<400> 2617
Xaa Gly Ala Arg Gly Arg Gly Ala Met Val Val Leu Arg Ala Gly Lys 
1               5                   10                  15      


Lys Xaa Phe Leu Pro Pro Leu Cys Arg Ala Phe Ala Cys Arg Gly Cys 
            20                  25                  30          


Gln Leu Ala Pro Glu Arg Gly Ala Glu Arg Arg Asp Xaa Ala Pro Ser 
        35                  40                  45              


Gly Val Ser Arg Phe Cys Pro Pro Arg Lys Ser Cys His Asp Trp Ile 
    50                  55                  60                  


Gly Pro Pro Asp Lys Tyr Ser Asn Leu Arg Pro Val His Phe Tyr Ile 
65                  70                  75                  80  


Pro Glu Asn Glu Ser Pro Leu Glu Gln Lys Leu Arg Lys Leu Arg Gln 
                85                  90                  95      


Glu Xaa Gln Glu Trp Asn Gln Gln Phe Trp Ala Asn Gln Asn Leu Xaa 
            100                 105                 110         


Phe Ser Lys Val Arg Lys Gln His 
        115                 120 


<210> 2618
<211> 57
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<400> 2618
Xaa Leu Arg Gln Glu Xaa Gln Glu Trp Asn Gln Gln Phe Trp Ala Asn 
1               5                   10                  15      


Gln Asn Leu Xaa Phe Ser Lys Met Glu Ser His Ser Val Xaa Gln Ala 
            20                  25                  30          


Gly Val Gln Trp His Asp Leu Gly Ser Leu Gln Xaa Leu Pro Pro Gly 
        35                  40                  45              


Ser Ser Asp Ser Pro Ala Ser Ala Phe 
    50                  55          


<210> 2619
<211> 746
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<400> 2619
Met Asp Gln Leu Glu Asp Leu Leu Val Leu Phe Ile Asn Tyr Val Pro 
1               5                   10                  15      


Xaa Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro Gln Ile Ala Met Phe 
            20                  25                  30          


Cys Gly Arg Leu Asn Met His Met Asn Val Gln Asn Gly Lys Trp Asp 
        35                  40                  45              


Ser Asp Pro Ser Gly Xaa Lys Xaa Cys Ile Asp Xaa Lys Glu Gly Ile 
    50                  55                  60                  


Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu Gln Ile Xaa Asn Val 
65                  70                  75                  80  


Val Glu Ala Asn Gln Pro Val Xaa Ile Gln Asn Trp Cys Lys Arg Gly 
                85                  90                  95      


Arg Lys Gln Cys Lys Xaa His Pro His Phe Val Ile Pro Tyr Arg Cys 
            100                 105                 110         


Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu Val Pro Asp Lys Cys 
        115                 120                 125             


Lys Phe Leu His Gln Glu Arg Met Asp Val Cys Glu Xaa His Leu His 
    130                 135                 140                 


Trp His Xaa Val Ala Lys Glu Xaa Cys Ser Glu Lys Ser Xaa Asn Leu 
145                 150                 155                 160 


His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile Asp Lys Phe Arg Gly 
                165                 170                 175     


Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu Ser Asp Asn Val Asp 
            180                 185                 190         


Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val Trp Trp Gly Gly Ala 
        195                 200                 205             


Asp Xaa Asp Tyr Ala Asp Gly Ser Glu Asp Lys Val Val Glu Val Ala 
    210                 215                 220                 


Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu Glu Ala Asp Asp Asp 
225                 230                 235                 240 


Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu Glu Ala Glu Glu Pro 
                245                 250                 255     


Tyr Glu Glu Ala Xaa Glu Arg Xaa Xaa Ser Ile Ala Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Glu Ser Val Glu Glu Val Val Arg Glu Val Cys Ser Glu 
        275                 280                 285             


Gln Ala Glu Xaa Gly Pro Cys Arg Ala Met Ile Ser Arg Trp Tyr Phe 
    290                 295                 300                 


Asp Val Xaa Glu Gly Lys Cys Ala Pro Phe Phe Tyr Gly Gly Cys Gly 
305                 310                 315                 320 


Gly Asn Arg Asn Asn Phe Asp Xaa Glu Glu Tyr Cys Met Ala Val Cys 
                325                 330                 335     


Gly Ser Ala Ile Pro Xaa Xaa Ala Ala Ser Xaa Pro Asp Ala Val Asp 
            340                 345                 350         


Lys Tyr Leu Glu Xaa Pro Gly Asp Glu Asn Glu His Ala His Phe Gln 
        355                 360                 365             


Lys Ala Lys Glu Arg Leu Glu Ala Lys His Arg Glu Arg Met Ser Gln 
    370                 375                 380                 


Val Met Arg Glu Trp Glu Glu Ala Glu Arg Gln Ala Lys Asn Leu Pro 
385                 390                 395                 400 


Lys Ala Asp Lys Lys Ala Val Ile Gln His Phe Gln Glu Lys Val Glu 
                405                 410                 415     


Ser Leu Glu Gln Glu Ala Ala Asn Glu Arg Gln Gln Leu Val Glu Xaa 
            420                 425                 430         


His Met Ala Arg Val Glu Ala Met Leu Asn Asp Arg Arg Arg Leu Ala 
        435                 440                 445             


Leu Glu Asn Tyr Ile Xaa Ala Leu Gln Ala Val Pro Pro Arg Pro Arg 
    450                 455                 460                 


His Val Phe Asn Met Leu Lys Lys Tyr Val Arg Ala Glu Gln Lys Asp 
465                 470                 475                 480 


Arg Gln His Xaa Leu Lys His Phe Glu His Val Arg Met Val Asp Pro 
                485                 490                 495     


Lys Lys Ala Ala Gln Ile Arg Ser Gln Val Met Xaa His Leu Arg Val 
            500                 505                 510         


Ile Tyr Glu Arg Met Asn Gln Ser Leu Ser Leu Leu Tyr Asn Val Pro 
        515                 520                 525             


Ala Val Ala Glu Glu Ile Gln Asp Glu Val Asp Glu Leu Leu Gln Lys 
    530                 535                 540                 


Glu Gln Asn Tyr Ser Asp Asp Val Leu Ala Asn Met Ile Ser Glu Pro 
545                 550                 555                 560 


Arg Ile Ser Tyr Gly Asn Asp Ala Leu Met Pro Ser Leu Xaa Glu Xaa 
                565                 570                 575     


Lys Xaa Xaa Val Glu Leu Leu Pro Val Asn Gly Glu Phe Ser Leu Asp 
            580                 585                 590         


Asp Leu Gln Pro Trp His Ser Phe Gly Ala Asp Ser Val Pro Ala Asn 
        595                 600                 605             


Xaa Glu Asn Glu Val Glu Pro Val Asp Ala Arg Pro Ala Ala Asp Arg 
    610                 615                 620                 


Gly Leu Xaa Xaa Arg Pro Gly Ser Gly Leu Xaa Asn Ile Lys Xaa Glu 
625                 630                 635                 640 


Glu Ile Ser Glu Val Lys Met Asp Ala Glu Phe Arg His Asp Ser Gly 
                645                 650                 655     


Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly 
            660                 665                 670         


Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile 
        675                 680                 685             


Ala Xaa Val Ile Val Ile Xaa Leu Val Met Leu Lys Lys Lys Gln Tyr 
    690                 695                 700                 


Xaa Ser Ile His His Gly Val Val Glu Val Asp Ala Ala Val Xaa Pro 
705                 710                 715                 720 


Glu Glu Arg His Leu Ser Lys Met Gln Gln Asn Gly Tyr Glu Asn Pro 
                725                 730                 735     


Xaa Tyr Lys Phe Phe Glu Gln Met Gln Asn 
            740                 745     


<210> 2620
<211> 660
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<400> 2620
Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln Asn Gly Lys 
1               5                   10                  15      


Trp Asp Ser Asp Pro Ser Gly Xaa Lys Xaa Cys Ile Asp Xaa Lys Glu 
            20                  25                  30          


Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu Gln Ile Xaa 
        35                  40                  45              


Asn Val Val Glu Ala Asn Gln Pro Val Xaa Ile Gln Asn Trp Cys Lys 
    50                  55                  60                  


Arg Gly Arg Lys Gln Cys Lys Xaa His Pro His Phe Val Ile Pro Tyr 
65                  70                  75                  80  


Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu Val Pro Asp 
                85                  90                  95      


Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys Glu Xaa His 
            100                 105                 110         


Leu His Trp His Xaa Val Ala Lys Glu Xaa Cys Ser Glu Lys Ser Xaa 
        115                 120                 125             


Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile Asp Lys Phe 
    130                 135                 140                 


Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu Ser Asp Asn 
145                 150                 155                 160 


Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val Trp Trp Gly 
                165                 170                 175     


Gly Ala Asp Xaa Asp Tyr Ala Asp Gly Ser Glu Asp Lys Val Val Glu 
            180                 185                 190         


Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu Glu Ala Asp 
        195                 200                 205             


Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu Glu Ala Glu 
    210                 215                 220                 


Glu Pro Tyr Glu Glu Ala Xaa Glu Arg Xaa Xaa Ser Ile Ala Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Glu Ser Val Glu Glu Val Val Arg Val Pro Xaa 
                245                 250                 255     


Xaa Ala Ala Ser Xaa Pro Asp Ala Val Asp Lys Tyr Leu Glu Xaa Pro 
            260                 265                 270         


Gly Asp Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu 
        275                 280                 285             


Glu Ala Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu 
    290                 295                 300                 


Glu Ala Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala 
305                 310                 315                 320 


Val Ile Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala 
                325                 330                 335     


Ala Asn Glu Arg Gln Gln Leu Val Glu Xaa His Met Ala Arg Val Glu 
            340                 345                 350         


Ala Met Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Xaa 
        355                 360                 365             


Ala Leu Gln Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu 
    370                 375                 380                 


Lys Lys Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Xaa Leu Lys 
385                 390                 395                 400 


His Phe Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile 
                405                 410                 415     


Arg Ser Gln Val Met Xaa His Leu Arg Val Ile Tyr Glu Arg Met Asn 
            420                 425                 430         


Gln Ser Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile 
        435                 440                 445             


Gln Asp Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp 
    450                 455                 460                 


Asp Val Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn 
465                 470                 475                 480 


Asp Ala Leu Met Pro Ser Leu Xaa Glu Xaa Lys Xaa Xaa Val Glu Leu 
                485                 490                 495     


Leu Pro Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His 
            500                 505                 510         


Ser Phe Gly Ala Asp Ser Val Pro Ala Asn Xaa Glu Asn Glu Val Glu 
        515                 520                 525             


Pro Val Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Xaa Xaa Arg Pro 
    530                 535                 540                 


Gly Ser Gly Leu Xaa Asn Ile Lys Xaa Glu Glu Ile Ser Glu Val Lys 
545                 550                 555                 560 


Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln 
                565                 570                 575     


Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile 
            580                 585                 590         


Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Xaa Val Ile Val Ile 
        595                 600                 605             


Xaa Leu Val Met Leu Lys Lys Lys Gln Tyr Xaa Ser Ile His His Gly 
    610                 615                 620                 


Val Val Glu Val Asp Ala Ala Val Xaa Pro Glu Glu Arg His Leu Ser 
625                 630                 635                 640 


Lys Met Gln Gln Asn Gly Tyr Glu Asn Pro Xaa Tyr Lys Phe Phe Glu 
                645                 650                 655     


Gln Met Gln Asn 
            660 


<210> 2621
<211> 695
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<400> 2621
Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Xaa Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Xaa Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Xaa Lys Xaa Cys Ile Asp 
    50                  55                  60                  


Xaa Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Xaa Asn Val Val Glu Ala Asn Gln Pro Val Xaa Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Xaa His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Xaa His Leu His Trp His Xaa Val Ala Lys Glu Xaa Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Xaa Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Xaa Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Xaa Glu Arg Xaa Xaa Ser Ile 
            260                 265                 270         


Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Val Pro Xaa Xaa Ala Ala Ser Xaa Pro Asp Ala Val Asp Lys Tyr Leu 
    290                 295                 300                 


Glu Xaa Pro Gly Asp Glu Asn Glu His Ala His Phe Gln Lys Ala Lys 
305                 310                 315                 320 


Glu Arg Leu Glu Ala Lys His Arg Glu Arg Met Ser Gln Val Met Arg 
                325                 330                 335     


Glu Trp Glu Glu Ala Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp 
            340                 345                 350         


Lys Lys Ala Val Ile Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu 
        355                 360                 365             


Gln Glu Ala Ala Asn Glu Arg Gln Gln Leu Val Glu Xaa His Met Ala 
    370                 375                 380                 


Arg Val Glu Ala Met Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn 
385                 390                 395                 400 


Tyr Ile Xaa Ala Leu Gln Ala Val Pro Pro Arg Pro Arg His Val Phe 
                405                 410                 415     


Asn Met Leu Lys Lys Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His 
            420                 425                 430         


Xaa Leu Lys His Phe Glu His Val Arg Met Val Asp Pro Lys Lys Ala 
        435                 440                 445             


Ala Gln Ile Arg Ser Gln Val Met Xaa His Leu Arg Val Ile Tyr Glu 
    450                 455                 460                 


Arg Met Asn Gln Ser Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala 
465                 470                 475                 480 


Glu Glu Ile Gln Asp Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn 
                485                 490                 495     


Tyr Ser Asp Asp Val Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser 
            500                 505                 510         


Tyr Gly Asn Asp Ala Leu Met Pro Ser Leu Xaa Glu Xaa Lys Xaa Xaa 
        515                 520                 525             


Val Glu Leu Leu Pro Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln 
    530                 535                 540                 


Pro Trp His Ser Phe Gly Ala Asp Ser Val Pro Ala Asn Xaa Glu Asn 
545                 550                 555                 560 


Glu Val Glu Pro Val Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Xaa 
                565                 570                 575     


Xaa Arg Pro Gly Ser Gly Leu Xaa Asn Ile Lys Xaa Glu Glu Ile Ser 
            580                 585                 590         


Glu Val Lys Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val 
        595                 600                 605             


His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys 
    610                 615                 620                 


Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Xaa Val 
625                 630                 635                 640 


Ile Val Ile Xaa Leu Val Met Leu Lys Lys Lys Gln Tyr Xaa Ser Ile 
                645                 650                 655     


His His Gly Val Val Glu Val Asp Ala Ala Val Xaa Pro Glu Glu Arg 
            660                 665                 670         


His Leu Ser Lys Met Gln Gln Asn Gly Tyr Glu Asn Pro Xaa Tyr Lys 
        675                 680                 685             


Phe Phe Glu Gln Met Gln Asn 
    690                 695 


<210> 2622
<211> 751
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<400> 2622
Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Xaa Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Xaa Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Xaa Lys Xaa Cys Ile Asp 
    50                  55                  60                  


Xaa Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Xaa Asn Val Val Glu Ala Asn Gln Pro Val Xaa Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Xaa His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Xaa His Leu His Trp His Xaa Val Ala Lys Glu Xaa Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Xaa Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Xaa Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Xaa Glu Arg Xaa Xaa Ser Ile 
            260                 265                 270         


Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Xaa Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Xaa Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Xaa Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Ile Pro Xaa Xaa Ala Ala Ser Xaa 
            340                 345                 350         


Pro Asp Ala Val Asp Lys Tyr Leu Glu Xaa Pro Gly Asp Glu Asn Glu 
        355                 360                 365             


His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala Lys His Arg 
    370                 375                 380                 


Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala Glu Arg Gln 
385                 390                 395                 400 


Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile Gln His Phe 
                405                 410                 415     


Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn Glu Arg Gln 
            420                 425                 430         


Gln Leu Val Glu Xaa His Met Ala Arg Val Glu Ala Met Leu Asn Asp 
        435                 440                 445             


Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Xaa Ala Leu Gln Ala Val 
    450                 455                 460                 


Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys Tyr Val Arg 
465                 470                 475                 480 


Ala Glu Gln Lys Asp Arg Gln His Xaa Leu Lys His Phe Glu His Val 
                485                 490                 495     


Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser Gln Val Met 
            500                 505                 510         


Xaa His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser Leu Ser Leu 
        515                 520                 525             


Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp Glu Val Asp 
    530                 535                 540                 


Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val Leu Ala Asn 
545                 550                 555                 560 


Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala Leu Met Pro 
                565                 570                 575     


Ser Leu Xaa Glu Xaa Lys Xaa Xaa Val Glu Leu Leu Pro Val Asn Gly 
            580                 585                 590         


Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe Gly Ala Asp 
        595                 600                 605             


Ser Val Pro Ala Asn Xaa Glu Asn Glu Val Glu Pro Val Asp Ala Arg 
    610                 615                 620                 


Pro Ala Ala Asp Arg Gly Leu Xaa Xaa Arg Pro Gly Ser Gly Leu Xaa 
625                 630                 635                 640 


Asn Ile Lys Xaa Glu Glu Ile Ser Glu Val Lys Met Asp Ala Glu Phe 
                645                 650                 655     


Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe 
            660                 665                 670         


Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val 
        675                 680                 685             


Gly Gly Val Val Ile Ala Xaa Val Ile Val Ile Xaa Leu Val Met Leu 
    690                 695                 700                 


Lys Lys Lys Gln Tyr Xaa Ser Ile His His Gly Val Val Glu Val Asp 
705                 710                 715                 720 


Ala Ala Val Xaa Pro Glu Glu Arg His Leu Ser Lys Met Gln Gln Asn 
                725                 730                 735     


Gly Tyr Glu Asn Pro Xaa Tyr Lys Phe Phe Glu Gln Met Gln Asn 
            740                 745                 750     


<210> 2623
<211> 752
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<400> 2623
Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Xaa Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Xaa Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Xaa Lys Xaa Cys Ile Asp 
    50                  55                  60                  


Xaa Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Xaa Asn Val Val Glu Ala Asn Gln Pro Val Xaa Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Xaa His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Xaa His Leu His Trp His Xaa Val Ala Lys Glu Xaa Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Xaa Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Xaa Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Xaa Glu Arg Xaa Xaa Ser Ile 
            260                 265                 270         


Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Xaa Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Xaa Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Xaa Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Xaa 
            340                 345                 350         


Xaa Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Xaa Xaa Ala 
        355                 360                 365             


Ala Ser Xaa Pro Asp Ala Val Asp Lys Tyr Leu Glu Xaa Pro Gly Asp 
    370                 375                 380                 


Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala 
385                 390                 395                 400 


Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala 
                405                 410                 415     


Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile 
            420                 425                 430         


Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn 
        435                 440                 445             


Glu Arg Gln Gln Leu Val Glu Xaa His Met Ala Arg Val Glu Ala Met 
    450                 455                 460                 


Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Xaa Ala Leu 
465                 470                 475                 480 


Gln Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys 
                485                 490                 495     


Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Xaa Leu Lys His Phe 
            500                 505                 510         


Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser 
        515                 520                 525             


Gln Val Met Xaa His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser 
    530                 535                 540                 


Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp 
545                 550                 555                 560 


Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val 
                565                 570                 575     


Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala 
            580                 585                 590         


Leu Met Pro Ser Leu Xaa Glu Xaa Lys Xaa Xaa Val Glu Leu Leu Pro 
        595                 600                 605             


Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe 
    610                 615                 620                 


Gly Ala Asp Ser Val Pro Ala Asn Xaa Glu Asn Glu Gly Ser Gly Leu 
625                 630                 635                 640 


Xaa Asn Ile Lys Xaa Glu Glu Ile Ser Glu Val Lys Met Asp Ala Glu 
                645                 650                 655     


Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe 
            660                 665                 670         


Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met 
        675                 680                 685             


Val Gly Gly Val Val Ile Ala Xaa Val Ile Val Ile Xaa Leu Val Met 
    690                 695                 700                 


Leu Lys Lys Lys Gln Tyr Xaa Ser Ile His His Gly Val Val Glu Val 
705                 710                 715                 720 


Asp Ala Ala Val Xaa Pro Glu Glu Arg His Leu Ser Lys Met Gln Gln 
                725                 730                 735     


Asn Gly Tyr Glu Asn Pro Xaa Tyr Lys Phe Phe Glu Gln Met Gln Asn 
            740                 745                 750         


<210> 2624
<211> 770
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<400> 2624
Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Xaa Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Xaa Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Xaa Lys Xaa Cys Ile Asp 
    50                  55                  60                  


Xaa Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Xaa Asn Val Val Glu Ala Asn Gln Pro Val Xaa Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Xaa His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Xaa His Leu His Trp His Xaa Val Ala Lys Glu Xaa Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Xaa Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Xaa Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Xaa Glu Arg Xaa Xaa Ser Ile 
            260                 265                 270         


Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Xaa Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Xaa Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Xaa Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Xaa 
            340                 345                 350         


Xaa Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Xaa Xaa Ala 
        355                 360                 365             


Ala Ser Xaa Pro Asp Ala Val Asp Lys Tyr Leu Glu Xaa Pro Gly Asp 
    370                 375                 380                 


Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala 
385                 390                 395                 400 


Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala 
                405                 410                 415     


Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile 
            420                 425                 430         


Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn 
        435                 440                 445             


Glu Arg Gln Gln Leu Val Glu Xaa His Met Ala Arg Val Glu Ala Met 
    450                 455                 460                 


Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Xaa Ala Leu 
465                 470                 475                 480 


Gln Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys 
                485                 490                 495     


Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Xaa Leu Lys His Phe 
            500                 505                 510         


Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser 
        515                 520                 525             


Gln Val Met Xaa His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser 
    530                 535                 540                 


Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp 
545                 550                 555                 560 


Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val 
                565                 570                 575     


Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala 
            580                 585                 590         


Leu Met Pro Ser Leu Xaa Glu Xaa Lys Xaa Xaa Val Glu Leu Leu Pro 
        595                 600                 605             


Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe 
    610                 615                 620                 


Gly Ala Asp Ser Val Pro Ala Asn Xaa Glu Asn Glu Val Glu Pro Val 
625                 630                 635                 640 


Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Xaa Xaa Arg Pro Gly Ser 
                645                 650                 655     


Gly Leu Xaa Asn Ile Lys Xaa Glu Glu Ile Ser Glu Val Lys Met Asp 
            660                 665                 670         


Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu 
        675                 680                 685             


Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly 
    690                 695                 700                 


Leu Met Val Gly Gly Val Val Ile Ala Xaa Val Ile Val Ile Xaa Leu 
705                 710                 715                 720 


Val Met Leu Lys Lys Lys Gln Tyr Xaa Ser Ile His His Gly Val Val 
                725                 730                 735     


Glu Val Asp Ala Ala Val Xaa Pro Glu Glu Arg His Leu Ser Lys Met 
            740                 745                 750         


Gln Gln Asn Gly Tyr Glu Asn Pro Xaa Tyr Lys Phe Phe Glu Gln Met 
        755                 760                 765             


Gln Asn 
    770 


<210> 2625
<211> 714
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<400> 2625
Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Xaa Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Tyr Pro Glu Leu Gln Ile Xaa Asn Val Val Glu Ala 
            20                  25                  30          


Asn Gln Pro Val Xaa Ile Gln Asn Trp Cys Lys Arg Gly Arg Lys Gln 
        35                  40                  45              


Cys Lys Xaa His Pro His Phe Val Ile Pro Tyr Arg Cys Leu Val Gly 
    50                  55                  60                  


Glu Phe Val Ser Asp Ala Leu Leu Val Pro Asp Lys Cys Lys Phe Leu 
65                  70                  75                  80  


His Gln Glu Arg Met Asp Val Cys Glu Xaa His Leu His Trp His Xaa 
                85                  90                  95      


Val Ala Lys Glu Xaa Cys Ser Glu Lys Ser Xaa Asn Leu His Asp Tyr 
            100                 105                 110         


Gly Met Leu Leu Pro Cys Gly Ile Asp Lys Phe Arg Gly Val Glu Phe 
        115                 120                 125             


Val Cys Cys Pro Leu Ala Glu Glu Ser Asp Asn Val Asp Ser Ala Asp 
    130                 135                 140                 


Ala Glu Glu Asp Asp Ser Asp Val Trp Trp Gly Gly Ala Asp Xaa Asp 
145                 150                 155                 160 


Tyr Ala Asp Gly Ser Glu Asp Lys Val Val Glu Val Ala Glu Glu Glu 
                165                 170                 175     


Glu Val Ala Glu Val Glu Glu Glu Glu Ala Asp Asp Asp Glu Asp Asp 
            180                 185                 190         


Glu Asp Gly Asp Glu Val Glu Glu Glu Ala Glu Glu Pro Tyr Glu Glu 
        195                 200                 205             


Ala Xaa Glu Arg Xaa Xaa Ser Ile Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Glu Ser Val Glu Glu Val Val Arg Glu Val Cys Ser Glu Gln Ala Glu 
225                 230                 235                 240 


Xaa Gly Pro Cys Arg Ala Met Ile Ser Arg Trp Tyr Phe Asp Val Xaa 
                245                 250                 255     


Glu Gly Lys Cys Ala Pro Phe Phe Tyr Gly Gly Cys Gly Gly Asn Arg 
            260                 265                 270         


Asn Asn Phe Asp Xaa Glu Glu Tyr Cys Met Ala Val Cys Gly Ser Ala 
        275                 280                 285             


Met Ser Gln Ser Leu Leu Lys Xaa Xaa Gln Glu Pro Leu Ala Arg Asp 
    290                 295                 300                 


Pro Val Lys Leu Pro Xaa Xaa Ala Ala Ser Xaa Pro Asp Ala Val Asp 
305                 310                 315                 320 


Lys Tyr Leu Glu Xaa Pro Gly Asp Glu Asn Glu His Ala His Phe Gln 
                325                 330                 335     


Lys Ala Lys Glu Arg Leu Glu Ala Lys His Arg Glu Arg Met Ser Gln 
            340                 345                 350         


Val Met Arg Glu Trp Glu Glu Ala Glu Arg Gln Ala Lys Asn Leu Pro 
        355                 360                 365             


Lys Ala Asp Lys Lys Ala Val Ile Gln His Phe Gln Glu Lys Val Glu 
    370                 375                 380                 


Ser Leu Glu Gln Glu Ala Ala Asn Glu Arg Gln Gln Leu Val Glu Xaa 
385                 390                 395                 400 


His Met Ala Arg Val Glu Ala Met Leu Asn Asp Arg Arg Arg Leu Ala 
                405                 410                 415     


Leu Glu Asn Tyr Ile Xaa Ala Leu Gln Ala Val Pro Pro Arg Pro Arg 
            420                 425                 430         


His Val Phe Asn Met Leu Lys Lys Tyr Val Arg Ala Glu Gln Lys Asp 
        435                 440                 445             


Arg Gln His Xaa Leu Lys His Phe Glu His Val Arg Met Val Asp Pro 
    450                 455                 460                 


Lys Lys Ala Ala Gln Ile Arg Ser Gln Val Met Xaa His Leu Arg Val 
465                 470                 475                 480 


Ile Tyr Glu Arg Met Asn Gln Ser Leu Ser Leu Leu Tyr Asn Val Pro 
                485                 490                 495     


Ala Val Ala Glu Glu Ile Gln Asp Glu Val Asp Glu Leu Leu Gln Lys 
            500                 505                 510         


Glu Gln Asn Tyr Ser Asp Asp Val Leu Ala Asn Met Ile Ser Glu Pro 
        515                 520                 525             


Arg Ile Ser Tyr Gly Asn Asp Ala Leu Met Pro Ser Leu Xaa Glu Xaa 
    530                 535                 540                 


Lys Xaa Xaa Val Glu Leu Leu Pro Val Asn Gly Glu Phe Ser Leu Asp 
545                 550                 555                 560 


Asp Leu Gln Pro Trp His Ser Phe Gly Ala Asp Ser Val Pro Ala Asn 
                565                 570                 575     


Xaa Glu Asn Glu Val Glu Pro Val Asp Ala Arg Pro Ala Ala Asp Arg 
            580                 585                 590         


Gly Leu Xaa Xaa Arg Pro Gly Ser Gly Leu Xaa Asn Ile Lys Xaa Glu 
        595                 600                 605             


Glu Ile Ser Glu Val Lys Met Asp Ala Glu Phe Arg His Asp Ser Gly 
    610                 615                 620                 


Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly 
625                 630                 635                 640 


Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile 
                645                 650                 655     


Ala Xaa Val Ile Val Ile Xaa Leu Val Met Leu Lys Lys Lys Gln Tyr 
            660                 665                 670         


Xaa Ser Ile His His Gly Val Val Glu Val Asp Ala Ala Val Xaa Pro 
        675                 680                 685             


Glu Glu Arg His Leu Ser Lys Met Gln Gln Asn Gly Tyr Glu Asn Pro 
    690                 695                 700                 


Xaa Tyr Lys Phe Phe Glu Gln Met Gln Asn 
705                 710                 


<210> 2626
<211> 639
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<400> 2626
Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Xaa Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Tyr Pro Glu Leu Gln Ile Xaa Asn Val Val Glu Ala 
            20                  25                  30          


Asn Gln Pro Val Xaa Ile Gln Asn Trp Cys Lys Arg Gly Arg Lys Gln 
        35                  40                  45              


Cys Lys Xaa His Pro His Phe Val Ile Pro Tyr Arg Cys Leu Val Gly 
    50                  55                  60                  


Glu Phe Val Ser Asp Ala Leu Leu Val Pro Asp Lys Cys Lys Phe Leu 
65                  70                  75                  80  


His Gln Glu Arg Met Asp Val Cys Glu Xaa His Leu His Trp His Xaa 
                85                  90                  95      


Val Ala Lys Glu Xaa Cys Ser Glu Lys Ser Xaa Asn Leu His Asp Tyr 
            100                 105                 110         


Gly Met Leu Leu Pro Cys Gly Ile Asp Lys Phe Arg Gly Val Glu Phe 
        115                 120                 125             


Val Cys Cys Pro Leu Ala Glu Glu Ser Asp Asn Val Asp Ser Ala Asp 
    130                 135                 140                 


Ala Glu Glu Asp Asp Ser Asp Val Trp Trp Gly Gly Ala Asp Xaa Asp 
145                 150                 155                 160 


Tyr Ala Asp Gly Ser Glu Asp Lys Val Val Glu Val Ala Glu Glu Glu 
                165                 170                 175     


Glu Val Ala Glu Val Glu Glu Glu Glu Ala Asp Asp Asp Glu Asp Asp 
            180                 185                 190         


Glu Asp Gly Asp Glu Val Glu Glu Glu Ala Glu Glu Pro Tyr Glu Glu 
        195                 200                 205             


Ala Xaa Glu Arg Xaa Xaa Ser Ile Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Glu Ser Val Glu Glu Val Val Arg Val Pro Xaa Xaa Ala Ala Ser Xaa 
225                 230                 235                 240 


Pro Asp Ala Val Asp Lys Tyr Leu Glu Xaa Pro Gly Asp Glu Asn Glu 
                245                 250                 255     


His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala Lys His Arg 
            260                 265                 270         


Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala Glu Arg Gln 
        275                 280                 285             


Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile Gln His Phe 
    290                 295                 300                 


Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn Glu Arg Gln 
305                 310                 315                 320 


Gln Leu Val Glu Xaa His Met Ala Arg Val Glu Ala Met Leu Asn Asp 
                325                 330                 335     


Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Xaa Ala Leu Gln Ala Val 
            340                 345                 350         


Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys Tyr Val Arg 
        355                 360                 365             


Ala Glu Gln Lys Asp Arg Gln His Xaa Leu Lys His Phe Glu His Val 
    370                 375                 380                 


Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser Gln Val Met 
385                 390                 395                 400 


Xaa His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser Leu Ser Leu 
                405                 410                 415     


Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp Glu Val Asp 
            420                 425                 430         


Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val Leu Ala Asn 
        435                 440                 445             


Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala Leu Met Pro 
    450                 455                 460                 


Ser Leu Xaa Glu Xaa Lys Xaa Xaa Val Glu Leu Leu Pro Val Asn Gly 
465                 470                 475                 480 


Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe Gly Ala Asp 
                485                 490                 495     


Ser Val Pro Ala Asn Xaa Glu Asn Glu Val Glu Pro Val Asp Ala Arg 
            500                 505                 510         


Pro Ala Ala Asp Arg Gly Leu Xaa Xaa Arg Pro Gly Ser Gly Leu Xaa 
        515                 520                 525             


Asn Ile Lys Xaa Glu Glu Ile Ser Glu Val Lys Met Asp Ala Glu Phe 
    530                 535                 540                 


Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe 
545                 550                 555                 560 


Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val 
                565                 570                 575     


Gly Gly Val Val Ile Ala Xaa Val Ile Val Ile Xaa Leu Val Met Leu 
            580                 585                 590         


Lys Lys Lys Gln Tyr Xaa Ser Ile His His Gly Val Val Glu Val Asp 
        595                 600                 605             


Ala Ala Val Xaa Pro Glu Glu Arg His Leu Ser Lys Met Gln Gln Asn 
    610                 615                 620                 


Gly Tyr Glu Asn Pro Xaa Tyr Lys Phe Phe Glu Gln Met Gln Asn 
625                 630                 635                 


<210> 2627
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 2627
Xaa Gly Gly Ala Asp Xaa Asp Tyr Ala Asp Gly Ser Glu Asp Lys Val 
1               5                   10                  15      


Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu Glu 
            20                  25                  30          


Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu Glu 
        35                  40                  45              


Ala Glu Glu Pro Tyr Glu Glu Ala Xaa Glu Arg Xaa Xaa Ser Ile Ala 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Ser Val Glu Glu Val Val Arg Val 
65                  70                  75                  80  


Ser Gln Ser Leu Leu Lys Xaa Xaa Gln Glu Pro Leu Ala Arg Asp Pro 
                85                  90                  95      


Val Lys Leu Pro Xaa Xaa Ala Ala Ser Xaa Pro Asp Ala Val Asp Lys 
            100                 105                 110         


Tyr Leu Glu Xaa Pro Gly Asp Glu Asn Glu His Ala His Phe Gln Lys 
        115                 120                 125             


Ala Lys Glu Arg Leu Glu Ala Lys His Arg Glu Arg Met Ser Gln Val 
    130                 135                 140                 


Met Arg Glu Trp Glu Glu Ala Glu Arg Gln Ala Lys Asn Leu Pro Lys 
145                 150                 155                 160 


Ala Asp Lys Lys Ala Val Ile Gln His Phe Gln Glu Lys Val Glu Ser 
                165                 170                 175     


Leu Glu Gln Glu Ala 
            180     


<210> 2628
<211> 485
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<400> 2628
Xaa Leu Gln Ile Xaa Asn Val Val Glu Ala Asn Gln Pro Val Xaa Ile 
1               5                   10                  15      


Gln Asn Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Xaa His Pro His 
            20                  25                  30          


Phe Val Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala 
        35                  40                  45              


Leu Leu Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp 
    50                  55                  60                  


Val Cys Glu Xaa His Leu His Trp His Xaa Val Ala Lys Glu Xaa Cys 
65                  70                  75                  80  


Ser Glu Lys Ser Xaa Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys 
                85                  90                  95      


Gly Ile Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala 
            100                 105                 110         


Glu Glu Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser 
        115                 120                 125             


Asp Val Trp Trp Gly Gly Ala Asp Xaa Asp Tyr Ala Asp Gly Ser Glu 
    130                 135                 140                 


Asp Lys Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu 
145                 150                 155                 160 


Glu Glu Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val 
                165                 170                 175     


Glu Glu Glu Ala Glu Glu Pro Tyr Glu Glu Ala Xaa Glu Arg Xaa Xaa 
            180                 185                 190         


Ser Ile Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Ser Val Glu Glu Val 
        195                 200                 205             


Val Arg Glu Val Cys Ser Glu Gln Ala Glu Xaa Gly Pro Cys Arg Ala 
    210                 215                 220                 


Met Ile Ser Arg Trp Tyr Phe Asp Val Xaa Glu Gly Lys Cys Ala Pro 
225                 230                 235                 240 


Phe Phe Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Xaa Glu 
                245                 250                 255     


Glu Tyr Cys Met Ala Val Cys Gly Ser Ala Ile Pro Xaa Xaa Ala Ala 
            260                 265                 270         


Ser Xaa Pro Asp Ala Val Asp Lys Tyr Leu Glu Xaa Pro Gly Asp Glu 
        275                 280                 285             


Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala Lys 
    290                 295                 300                 


His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala Glu 
305                 310                 315                 320 


Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile Gln 
                325                 330                 335     


His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn Glu 
            340                 345                 350         


Arg Gln Gln Leu Val Glu Xaa His Met Ala Arg Val Glu Ala Met Leu 
        355                 360                 365             


Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Xaa Ala Leu Gln 
    370                 375                 380                 


Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys Tyr 
385                 390                 395                 400 


Val Arg Ala Glu Gln Lys Asp Arg Gln His Xaa Leu Lys His Phe Glu 
                405                 410                 415     


His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser Gln 
            420                 425                 430         


Val Met Xaa His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser Leu 
        435                 440                 445             


Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp Glu 
    450                 455                 460                 


Val Gly Ala Val Ala His Ala Cys Asn Ser Ser Ile Leu Gly Gly Gln 
465                 470                 475                 480 


Gly Gly Gln Met Xaa 
                485 


<210> 2629
<211> 114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<400> 2629
Met Pro Gly Ile Asp Lys Leu Pro Ile Glu Glu Xaa Leu Glu Asp Ser 
1               5                   10                  15      


Pro Gln Xaa Arg Ser Leu Leu Gly Val Phe Glu Glu Asp Ala Xaa Ala 
            20                  25                  30          


Ile Ser Asn Tyr Met Asn Gln Leu Tyr Gln Ala Met His Arg Ile Tyr 
        35                  40                  45              


Asp Ala Gln Asn Glu Leu Ser Ala Ala Xaa His Leu Xaa Ser Lys Leu 
    50                  55                  60                  


Leu Lys Glu Tyr Glu Lys Gln Leu Ser Ser Cys His Ala Val Leu Ser 
65                  70                  75                  80  


Xaa Gln Leu Ala Asp Ala Met Met Phe Pro Ile Xaa Gln Phe Lys Glu 
                85                  90                  95      


Arg Asp Leu Lys Glu Ile Leu Xaa Leu Lys Glu Val Phe Gln Ile Ala 
            100                 105                 110         


Ser Asn 
        


<210> 2630
<211> 709
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<400> 2630
Met Pro Gly Ile Asp Lys Leu Pro Ile Glu Glu Xaa Leu Glu Asp Ser 
1               5                   10                  15      


Pro Gln Xaa Arg Ser Leu Leu Gly Val Phe Glu Glu Asp Ala Xaa Ala 
            20                  25                  30          


Ile Ser Asn Tyr Met Asn Gln Leu Tyr Gln Ala Met His Arg Ile Tyr 
        35                  40                  45              


Asp Ala Gln Asn Glu Leu Ser Ala Ala Xaa His Leu Xaa Ser Lys Leu 
    50                  55                  60                  


Leu Lys Glu Tyr Glu Lys Gln Arg Phe Pro Leu Gly Gly Asp Asp Glu 
65                  70                  75                  80  


Val Met Ser Ser Xaa Leu Gln Gln Phe Ser Lys Val Ile Asp Glu Leu 
                85                  90                  95      


Ser Ser Cys His Ala Val Leu Ser Xaa Gln Leu Ala Asp Ala Met Met 
            100                 105                 110         


Phe Pro Ile Xaa Gln Phe Lys Glu Arg Asp Leu Lys Glu Ile Leu Xaa 
        115                 120                 125             


Leu Lys Glu Val Phe Gln Ile Ala Ser Asn Asp His Asp Ala Ala Ile 
    130                 135                 140                 


Asn Arg Tyr Ser Arg Leu Ser Lys Lys Arg Glu Asn Asp Lys Val Lys 
145                 150                 155                 160 


Tyr Glu Val Xaa Glu Asp Val Tyr Xaa Ser Arg Lys Lys Gln His Gln 
                165                 170                 175     


Xaa Met Met His Tyr Phe Cys Ala Leu Asn Xaa Leu Gln Tyr Lys Lys 
            180                 185                 190         


Lys Ile Ala Leu Leu Glu Pro Leu Leu Gly Tyr Met Gln Ala Gln Ile 
        195                 200                 205             


Ser Phe Phe Lys Met Gly Ser Glu Asn Leu Asn Glu Gln Leu Glu Glu 
    210                 215                 220                 


Phe Leu Ala Asn Ile Gly Xaa Ser Val Gln Asn Val Arg Arg Glu Met 
225                 230                 235                 240 


Asp Ser Asp Ile Glu Xaa Met Gln Gln Xaa Ile Glu Asp Leu Glu Val 
                245                 250                 255     


Ala Ser Asp Pro Leu Tyr Val Pro Asp Pro Asp Pro Xaa Lys Phe Pro 
            260                 265                 270         


Val Asn Arg Asn Leu Xaa Arg Lys Ala Gly Tyr Leu Asn Ala Arg Asn 
        275                 280                 285             


Lys Xaa Gly Leu Val Ser Ser Xaa Trp Asp Arg Gln Phe Tyr Phe Xaa 
    290                 295                 300                 


Gln Gly Gly Asn Leu Met Ser Gln Ala Arg Gly Asp Val Ala Gly Gly 
305                 310                 315                 320 


Leu Ala Met Asp Ile Asp Asn Cys Ser Val Met Ala Val Asp Cys Glu 
                325                 330                 335     


Asp Arg Arg Tyr Cys Phe Gln Ile Xaa Ser Phe Asp Gly Lys Lys Ser 
            340                 345                 350         


Ser Ile Leu Gln Ala Glu Ser Lys Lys Asp His Glu Glu Trp Ile Cys 
        355                 360                 365             


Xaa Ile Asn Asn Ile Ser Lys Gln Ile Tyr Leu Ser Glu Asn Pro Glu 
    370                 375                 380                 


Glu Xaa Ala Ala Arg Val Asn Gln Ser Ala Leu Glu Ala Val Xaa Pro 
385                 390                 395                 400 


Ser Pro Ser Phe Gln Gln Arg His Glu Ser Leu Arg Pro Ala Ala Gly 
                405                 410                 415     


Gln Ser Arg Pro Pro Xaa Ala Arg Xaa Ser Ser Ser Gly Ser Leu Gly 
            420                 425                 430         


Ser Glu Ser Xaa Asn Leu Ala Ala Leu Ser Leu Asp Ser Leu Val Ala 
        435                 440                 445             


Pro Asp Xaa Pro Ile Gln Phe Asp Ile Ile Ser Pro Val Cys Glu Asp 
    450                 455                 460                 


Gln Pro Gly Gln Ala Lys Ala Phe Gly Gln Gly Gly Arg Arg Xaa Asn 
465                 470                 475                 480 


Pro Phe Gly Glu Ser Gly Gly Ser Xaa Lys Ser Glu Xaa Glu Asp Ser 
                485                 490                 495     


Ile Leu His Gln Leu Phe Ile Val Arg Phe Leu Gly Ser Met Glu Val 
            500                 505                 510         


Lys Ser Asp Asp His Pro Asp Val Val Tyr Glu Xaa Met Arg Gln Ile 
        515                 520                 525             


Leu Ala Ala Arg Ala Ile His Asn Ile Phe Arg Met Xaa Glu Ser His 
    530                 535                 540                 


Leu Leu Val Xaa Cys Asp Cys Leu Lys Leu Ile Asp Pro Gln Xaa Gln 
545                 550                 555                 560 


Val Xaa Arg Leu Xaa Phe Pro Leu Pro Cys Val Val Leu Tyr Ala Xaa 
                565                 570                 575     


His Gln Glu Asn Lys Arg Leu Phe Gly Phe Val Leu Arg Xaa Ser Ser 
            580                 585                 590         


Gly Arg Ser Glu Ser Asn Leu Ser Ser Val Cys Tyr Ile Phe Glu Ser 
        595                 600                 605             


Asn Asn Glu Gly Glu Lys Ile Cys Asp Ser Val Gly Leu Ala Lys Gln 
    610                 615                 620                 


Ile Ala Leu His Ala Glu Leu Asp Arg Arg Ala Ser Glu Lys Gln Lys 
625                 630                 635                 640 


Glu Ile Glu Arg Val Lys Glu Lys Gln Gln Lys Glu Leu Asn Lys Gln 
                645                 650                 655     


Lys Gln Ile Glu Lys Asp Leu Glu Glu Gln Ser Arg Leu Ile Ala Ala 
            660                 665                 670         


Ser Ser Arg Pro Asn Gln Ala Ser Ser Glu Gly Gln Phe Val Val Leu 
        675                 680                 685             


Ser Ser Ser Gln Ser Glu Glu Ser Asp Leu Gly Glu Gly Gly Lys Lys 
    690                 695                 700                 


Arg Glu Ser Glu Ala 
705                 


<210> 2631
<211> 134
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 2631
Met Xaa Arg Ser Leu Leu Gly Val Phe Glu Glu Asp Ala Xaa Ala Ile 
1               5                   10                  15      


Ser Asn Tyr Met Asn Gln Leu Tyr Gln Ala Met His Arg Ile Tyr Asp 
            20                  25                  30          


Ala Gln Asn Glu Leu Ser Ala Ala Xaa His Leu Xaa Ser Lys Leu Leu 
        35                  40                  45              


Lys Glu Tyr Glu Lys Gln Arg Phe Pro Leu Gly Gly Asp Asp Glu Val 
    50                  55                  60                  


Met Ser Ser Xaa Leu Gln Gln Phe Ser Lys Val Ile Asp Glu Leu Ser 
65                  70                  75                  80  


Ser Cys His Ala Val Leu Ser Xaa Gln Leu Ala Asp Ala Met Met Phe 
                85                  90                  95      


Pro Ile Xaa Gln Phe Lys Glu Arg Asp Leu Lys Glu Ile Leu Xaa Leu 
            100                 105                 110         


Lys Glu Val Phe Gln Ile Ala Ser Asn Asp His Asp Ala Ala Ile Asn 
        115                 120                 125             


Arg Tyr Ser Arg Leu Ser 
    130                 


<210> 2632
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 2632
Asp Ile Val Leu Pro Ala Xaa Glu Phe Leu Asp Gln Asn Arg Gly Ser 
1               5                   10                  15      


Arg Arg Xaa Asn Pro Phe Gly Glu Xaa Glu Asp Glu Ser Phe Pro Glu 
            20                  25                  30          


Ala Glu Val Lys Xaa Asp Ser Xaa Xaa Glu Val Ile Tyr Glu Ala Met 
        35                  40                  45              


Arg Gln Val Leu Ala Ala Arg Ala Ile His Asn Ile Phe Arg Met Xaa 
    50                  55                  60                  


Glu Ser His Leu Met Val Xaa Ser Gln Ser Leu Arg Leu Ile Asp Pro 
65                  70                  75                  80  


Gln Xaa Gln Val Ser Arg Ala Asn Phe Glu Leu Xaa Ser Val Xaa Gln 
                85                  90                  95      


Phe Ala Ala His Gln Glu Asn Lys Arg Leu Val Gly Phe Val Ile Arg 
            100                 105                 110         


Val Pro Glu Ser Xaa Gly Glu Glu Ser Leu Ser Xaa Tyr Ile Phe Glu 
        115                 120                 125             


Ser Asn Ser Glu Gly Glu Lys Ile Cys Tyr Ala Ile Asn Leu Gly Lys 
    130                 135                 140                 


Glu Ile Ile Glu Val Gln Lys Asp Pro Glu Ala Leu Ala Gln Leu Met 
145                 150                 155                 160 


Leu Ser Ile Pro Leu Xaa Asn Asp Gly Lys Tyr Val Leu Leu Asn Asp 
                165                 170                 175     


Gln Pro Asp Asp Asp Asp Gly Asn Pro Asn Glu His 
            180                 185             


<210> 2633
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 2633
Met Pro Ala Val Asp Lys Leu Leu Leu Glu Glu Ala Leu Gln Asp Ser 
1               5                   10                  15      


Pro Gln Asn Glu Met Cys Leu Ala Xaa Gln Gln Leu Ser Lys Gln Leu 
            20                  25                  30          


Leu Ala Tyr Glu Lys Gln Asn Phe Ala Leu Gly Lys Gly Asp Glu Glu 
        35                  40                  45              


Val Ile Ser Xaa Leu His Tyr Phe Ser Lys Val Val Asp Glu Leu Asn 
    50                  55                  60                  


Leu Leu His Xaa Glu Leu Ala Lys Gln Leu Ala Asp Xaa Met Val Leu 
65                  70                  75                  80  


Pro Ile Ile Gln Phe Arg Glu Lys Asp Leu Xaa Glu Val Ser Xaa Leu 
                85                  90                  95      


Lys Asp Leu Phe Gly Leu Ala Ser Asn Glu His Asp Leu Ser Met Ala 
            100                 105                 110         


Lys Tyr Ser Arg Leu Pro Lys Lys Lys Glu Asn Glu Lys Val Lys Xaa 
        115                 120                 125             


Glu Val Gly Lys Glu Val Ala Ala Ala Arg Arg Lys Gln His Leu Ser 
    130                 135                 140                 


<210> 2634
<211> 670
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<400> 2634
Met Pro Ala Val Asp Lys Leu Leu Leu Glu Glu Ala Leu Gln Asp Ser 
1               5                   10                  15      


Pro Gln Xaa Arg Ser Leu Leu Ser Val Phe Glu Glu Asp Ala Gly Xaa 
            20                  25                  30          


Leu Xaa Asp Tyr Xaa Asn Gln Leu Leu Gln Ala Met Gln Arg Val Tyr 
        35                  40                  45              


Gly Ala Gln Asn Glu Met Cys Leu Ala Xaa Gln Gln Leu Ser Lys Gln 
    50                  55                  60                  


Leu Leu Ala Tyr Glu Lys Gln Asn Phe Ala Leu Gly Lys Gly Asp Glu 
65                  70                  75                  80  


Glu Val Ile Ser Xaa Leu His Tyr Phe Ser Lys Val Val Asp Glu Leu 
                85                  90                  95      


Asn Leu Leu His Xaa Glu Leu Ala Lys Gln Leu Ala Asp Xaa Met Val 
            100                 105                 110         


Leu Pro Ile Ile Gln Phe Arg Glu Lys Asp Leu Xaa Glu Val Ser Xaa 
        115                 120                 125             


Leu Lys Asp Leu Phe Gly Leu Ala Ser Asn Asp Val Cys Leu Phe Leu 
    130                 135                 140                 


Glu His Asp Leu Ser Met Ala Lys Tyr Ser Arg Leu Pro Lys Lys Lys 
145                 150                 155                 160 


Glu Asn Glu Lys Val Lys Xaa Glu Val Gly Lys Glu Val Ala Ala Ala 
                165                 170                 175     


Arg Arg Lys Gln His Leu Ser Ser Leu Gln Tyr Tyr Cys Ala Leu Asn 
            180                 185                 190         


Ala Leu Gln Tyr Arg Lys Gln Met Ala Met Met Glu Pro Met Ile Gly 
        195                 200                 205             


Phe Ala His Gly Gln Ile Asn Phe Phe Lys Lys Gly Ala Glu Met Phe 
    210                 215                 220                 


Ser Lys Arg Met Asp Ser Phe Leu Ser Ser Val Ala Asp Met Val Gln 
225                 230                 235                 240 


Ser Ile Gln Val Glu Leu Glu Ala Glu Ala Glu Lys Met Arg Val Ser 
                245                 250                 255     


Gln Gln Glu Leu Leu Ser Val Asp Glu Ser Val Tyr Xaa Pro Asp Ser 
            260                 265                 270         


Asp Val Ala Ala Pro Gln Ile Asn Arg Asn Leu Ile Gln Lys Ala Gly 
        275                 280                 285             


Tyr Leu Asn Leu Arg Asn Lys Xaa Gly Leu Val Xaa Xaa Xaa Trp Glu 
    290                 295                 300                 


Arg Leu Tyr Phe Phe Xaa Gln Gly Gly Asn Leu Met Cys Gln Pro Arg 
305                 310                 315                 320 


Gly Ala Val Ala Gly Gly Leu Ile Gln Asp Leu Asp Asn Cys Ser Val 
                325                 330                 335     


Met Ala Val Asp Cys Glu Asp Arg Arg Tyr Cys Phe Gln Ile Xaa Xaa 
            340                 345                 350         


Pro Asn Gly Lys Ser Gly Ile Ile Leu Gln Ala Glu Ser Arg Lys Glu 
        355                 360                 365             


Asn Glu Glu Trp Ile Cys Ala Ile Asn Asn Ile Ser Arg Gln Ile Tyr 
    370                 375                 380                 


Leu Xaa Asp Asn Pro Glu Ala Val Ala Ile Lys Leu Asn Gln Xaa Ala 
385                 390                 395                 400 


Leu Gln Ala Val Xaa Pro Ile Xaa Ser Phe Gly Lys Lys Gln Glu Ser 
                405                 410                 415     


Ser Cys Pro Ser Gln Asn Leu Lys Asn Ser Glu Met Glu Asn Glu Asn 
            420                 425                 430         


Asp Lys Ile Val Pro Lys Ala Xaa Ala Ser Leu Pro Glu Ala Glu Glu 
        435                 440                 445             


Leu Ile Ala Pro Gly Xaa Pro Ile Gln Phe Asp Ile Val Leu Pro Ala 
    450                 455                 460                 


Xaa Glu Phe Leu Asp Gln Asn Arg Gly Ser Arg Arg Xaa Asn Pro Phe 
465                 470                 475                 480 


Gly Glu Xaa Glu Asp Glu Ser Phe Pro Glu Ala Glu Asp Ser Leu Leu 
                485                 490                 495     


Gln Gln Met Phe Ile Val Arg Phe Leu Gly Ser Met Ala Val Lys Xaa 
            500                 505                 510         


Asp Ser Xaa Xaa Glu Val Ile Tyr Glu Ala Met Arg Gln Val Leu Ala 
        515                 520                 525             


Ala Arg Ala Ile His Asn Ile Phe Arg Met Xaa Glu Ser His Leu Met 
    530                 535                 540                 


Val Xaa Ser Gln Ser Leu Arg Leu Ile Asp Pro Gln Xaa Gln Val Ser 
545                 550                 555                 560 


Arg Ala Asn Phe Glu Leu Xaa Ser Val Xaa Gln Phe Ala Ala His Gln 
                565                 570                 575     


Glu Asn Lys Arg Leu Val Gly Phe Val Ile Arg Val Pro Glu Ser Xaa 
            580                 585                 590         


Gly Glu Glu Ser Leu Ser Xaa Tyr Ile Phe Glu Ser Asn Ser Glu Gly 
        595                 600                 605             


Glu Lys Ile Cys Tyr Ala Ile Asn Leu Gly Lys Glu Ile Ile Glu Val 
    610                 615                 620                 


Gln Lys Asp Pro Glu Ala Leu Ala Gln Leu Met Leu Ser Ile Pro Leu 
625                 630                 635                 640 


Xaa Asn Asp Gly Lys Tyr Val Leu Leu Asn Asp Gln Pro Asp Asp Asp 
                645                 650                 655     


Asp Gly Asn Pro Asn Glu His Arg Gly Ala Glu Ser Glu Ala 
            660                 665                 670 


<210> 2635
<211> 235
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<400> 2635
Met Pro Ala Val Asp Lys Leu Leu Leu Glu Glu Ala Leu Gln Asp Ser 
1               5                   10                  15      


Pro Gln Xaa Arg Ser Leu Leu Ser Val Phe Glu Glu Asp Ala Gly Xaa 
            20                  25                  30          


Leu Xaa Asp Tyr Xaa Asn Gln Leu Leu Gln Ala Met Gln Arg Val Tyr 
        35                  40                  45              


Gly Ala Gln Asn Glu Met Cys Leu Ala Xaa Gln Gln Leu Ser Lys Gln 
    50                  55                  60                  


Leu Leu Ala Tyr Glu Lys Gln Asn Phe Ala Leu Gly Lys Gly Asp Glu 
65                  70                  75                  80  


Glu Val Ile Ser Xaa Leu His Tyr Phe Ser Lys Val Val Asp Glu Leu 
                85                  90                  95      


Asn Leu Leu His Xaa Glu Leu Ala Lys Gln Leu Ala Asp Xaa Met Val 
            100                 105                 110         


Leu Pro Ile Ile Gln Phe Arg Glu Lys Asp Leu Xaa Glu Val Ser Xaa 
        115                 120                 125             


Leu Lys Asp Leu Phe Gly Leu Ala Ser Asn Glu His Asp Leu Ser Met 
    130                 135                 140                 


Ala Lys Tyr Ser Arg Leu Pro Lys Lys Lys Glu Asn Glu Lys Val Lys 
145                 150                 155                 160 


Xaa Glu Val Gly Lys Glu Val Ala Ala Ala Arg Arg Lys Gln His Leu 
                165                 170                 175     


Ser Ser Leu Gln Tyr Tyr Cys Ala Leu Asn Ala Leu Gln Tyr Arg Lys 
            180                 185                 190         


Gln Met Ala Met Met Glu Pro Met Ile Gly Phe Ala His Gly Gln Ile 
        195                 200                 205             


Asn Phe Phe Lys Lys Gly Ala Glu Met Phe Ser Lys Arg Met Asp Ser 
    210                 215                 220                 


Phe Leu Ser Ser Val Ala Asp Met Val Gln Arg 
225                 230                 235 


<210> 2636
<211> 664
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<400> 2636
Met Pro Ala Val Asp Lys Leu Leu Leu Glu Glu Ala Leu Gln Asp Ser 
1               5                   10                  15      


Pro Gln Xaa Arg Ser Leu Leu Ser Val Phe Glu Glu Asp Ala Gly Xaa 
            20                  25                  30          


Leu Xaa Asp Tyr Xaa Asn Gln Leu Leu Gln Ala Met Gln Arg Val Tyr 
        35                  40                  45              


Gly Ala Gln Asn Glu Met Cys Leu Ala Xaa Gln Gln Leu Ser Lys Gln 
    50                  55                  60                  


Leu Leu Ala Tyr Glu Lys Gln Asn Phe Ala Leu Gly Lys Gly Asp Glu 
65                  70                  75                  80  


Glu Val Ile Ser Xaa Leu His Tyr Phe Ser Lys Val Val Asp Glu Leu 
                85                  90                  95      


Asn Leu Leu His Xaa Glu Leu Ala Lys Gln Leu Ala Asp Xaa Met Val 
            100                 105                 110         


Leu Pro Ile Ile Gln Phe Arg Glu Lys Asp Leu Xaa Glu Val Ser Xaa 
        115                 120                 125             


Leu Lys Asp Leu Phe Gly Leu Ala Ser Asn Glu His Asp Leu Ser Met 
    130                 135                 140                 


Ala Lys Tyr Ser Arg Leu Pro Lys Lys Lys Glu Asn Glu Lys Val Lys 
145                 150                 155                 160 


Xaa Glu Val Gly Lys Glu Val Ala Ala Ala Arg Arg Lys Gln His Leu 
                165                 170                 175     


Ser Ser Leu Gln Tyr Tyr Cys Ala Leu Asn Ala Leu Gln Tyr Arg Lys 
            180                 185                 190         


Gln Met Ala Met Met Glu Pro Met Ile Gly Phe Ala His Gly Gln Ile 
        195                 200                 205             


Asn Phe Phe Lys Lys Gly Ala Glu Met Phe Ser Lys Arg Met Asp Ser 
    210                 215                 220                 


Phe Leu Ser Ser Val Ala Asp Met Val Gln Ser Ile Gln Val Glu Leu 
225                 230                 235                 240 


Glu Ala Glu Ala Glu Lys Met Arg Val Ser Gln Gln Glu Leu Leu Ser 
                245                 250                 255     


Val Asp Glu Ser Val Tyr Xaa Pro Asp Ser Asp Val Ala Ala Pro Gln 
            260                 265                 270         


Ile Asn Arg Asn Leu Ile Gln Lys Ala Gly Tyr Leu Asn Leu Arg Asn 
        275                 280                 285             


Lys Xaa Gly Leu Val Xaa Xaa Xaa Trp Glu Arg Leu Tyr Phe Phe Xaa 
    290                 295                 300                 


Gln Gly Gly Asn Leu Met Cys Gln Pro Arg Gly Ala Val Ala Gly Gly 
305                 310                 315                 320 


Leu Ile Gln Asp Leu Asp Asn Cys Ser Val Met Ala Val Asp Cys Glu 
                325                 330                 335     


Asp Arg Arg Tyr Cys Phe Gln Ile Xaa Xaa Pro Asn Gly Lys Ser Gly 
            340                 345                 350         


Ile Ile Leu Gln Ala Glu Ser Arg Lys Glu Asn Glu Glu Trp Ile Cys 
        355                 360                 365             


Ala Ile Asn Asn Ile Ser Arg Gln Ile Tyr Leu Xaa Asp Asn Pro Glu 
    370                 375                 380                 


Ala Val Ala Ile Lys Leu Asn Gln Xaa Ala Leu Gln Ala Val Xaa Pro 
385                 390                 395                 400 


Ile Xaa Ser Phe Gly Lys Lys Gln Glu Ser Ser Cys Pro Ser Gln Asn 
                405                 410                 415     


Leu Lys Asn Ser Glu Met Glu Asn Glu Asn Asp Lys Ile Val Pro Lys 
            420                 425                 430         


Ala Xaa Ala Ser Leu Pro Glu Ala Glu Glu Leu Ile Ala Pro Gly Xaa 
        435                 440                 445             


Pro Ile Gln Phe Asp Ile Val Leu Pro Ala Xaa Glu Phe Leu Asp Gln 
    450                 455                 460                 


Asn Arg Gly Ser Arg Arg Xaa Asn Pro Phe Gly Glu Xaa Glu Asp Glu 
465                 470                 475                 480 


Ser Phe Pro Glu Ala Glu Asp Ser Leu Leu Gln Gln Met Phe Ile Val 
                485                 490                 495     


Arg Phe Leu Gly Ser Met Ala Val Lys Xaa Asp Ser Xaa Xaa Glu Val 
            500                 505                 510         


Ile Tyr Glu Ala Met Arg Gln Val Leu Ala Ala Arg Ala Ile His Asn 
        515                 520                 525             


Ile Phe Arg Met Xaa Glu Ser His Leu Met Val Xaa Ser Gln Ser Leu 
    530                 535                 540                 


Arg Leu Ile Asp Pro Gln Xaa Gln Val Ser Arg Ala Asn Phe Glu Leu 
545                 550                 555                 560 


Xaa Ser Val Xaa Gln Phe Ala Ala His Gln Glu Asn Lys Arg Leu Val 
                565                 570                 575     


Gly Phe Val Ile Arg Val Pro Glu Ser Xaa Gly Glu Glu Ser Leu Ser 
            580                 585                 590         


Xaa Tyr Ile Phe Glu Ser Asn Ser Glu Gly Glu Lys Ile Cys Tyr Ala 
        595                 600                 605             


Ile Asn Leu Gly Lys Glu Ile Ile Glu Val Gln Lys Asp Pro Glu Ala 
    610                 615                 620                 


Leu Ala Gln Leu Met Leu Ser Ile Pro Leu Xaa Asn Asp Gly Lys Tyr 
625                 630                 635                 640 


Val Leu Leu Asn Asp Gln Pro Asp Asp Asp Asp Gly Asn Pro Asn Glu 
                645                 650                 655     


His Arg Gly Ala Glu Ser Glu Ala 
            660                 


<210> 2637
<211> 61
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<400> 2637
Met Gln Arg Val Tyr Gly Ala Gln Asn Glu Met Cys Leu Ala Xaa Gln 
1               5                   10                  15      


Gln Leu Ser Lys Gln Leu Leu Ala Tyr Glu Lys Gln Asn Phe Ala Leu 
            20                  25                  30          


Gly Lys Gly Asp Glu Glu Val Ile Ser Xaa Leu His Tyr Phe Ser Lys 
        35                  40                  45              


Val Val Asp Glu Leu Asn Leu Leu His Xaa Glu Leu Ala 
    50                  55                  60      


<210> 2638
<211> 621
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<400> 2638
Met Gln Arg Val Tyr Gly Ala Gln Asn Glu Met Cys Leu Ala Xaa Gln 
1               5                   10                  15      


Gln Leu Ser Lys Gln Leu Leu Ala Tyr Glu Lys Gln Asn Phe Ala Leu 
            20                  25                  30          


Gly Lys Gly Asp Glu Glu Val Ile Ser Xaa Leu His Tyr Phe Ser Lys 
        35                  40                  45              


Val Val Asp Glu Leu Asn Leu Leu His Xaa Glu Leu Ala Lys Gln Leu 
    50                  55                  60                  


Ala Asp Xaa Met Val Leu Pro Ile Ile Gln Phe Arg Glu Lys Asp Leu 
65                  70                  75                  80  


Xaa Glu Val Ser Xaa Leu Lys Asp Leu Phe Gly Leu Ala Ser Asn Glu 
                85                  90                  95      


His Asp Leu Ser Met Ala Lys Tyr Ser Arg Leu Pro Lys Lys Lys Glu 
            100                 105                 110         


Asn Glu Lys Val Lys Xaa Glu Val Gly Lys Glu Val Ala Ala Ala Arg 
        115                 120                 125             


Arg Lys Gln His Leu Ser Ser Leu Gln Tyr Tyr Cys Ala Leu Asn Ala 
    130                 135                 140                 


Leu Gln Tyr Arg Lys Gln Met Ala Met Met Glu Pro Met Ile Gly Phe 
145                 150                 155                 160 


Ala His Gly Gln Ile Asn Phe Phe Lys Lys Gly Ala Glu Met Phe Ser 
                165                 170                 175     


Lys Arg Met Asp Ser Phe Leu Ser Ser Val Ala Asp Met Val Gln Ser 
            180                 185                 190         


Ile Gln Val Glu Leu Glu Ala Glu Ala Glu Lys Met Arg Val Ser Gln 
        195                 200                 205             


Gln Glu Leu Leu Ser Val Asp Glu Ser Val Tyr Xaa Pro Asp Ser Asp 
    210                 215                 220                 


Val Ala Ala Pro Gln Ile Asn Arg Asn Leu Ile Gln Lys Ala Gly Tyr 
225                 230                 235                 240 


Leu Asn Leu Arg Asn Lys Xaa Gly Leu Val Xaa Xaa Xaa Trp Glu Arg 
                245                 250                 255     


Leu Tyr Phe Phe Xaa Gln Gly Gly Asn Leu Met Cys Gln Pro Arg Gly 
            260                 265                 270         


Ala Val Ala Gly Gly Leu Ile Gln Asp Leu Asp Asn Cys Ser Val Met 
        275                 280                 285             


Ala Val Asp Cys Glu Asp Arg Arg Tyr Cys Phe Gln Ile Xaa Xaa Pro 
    290                 295                 300                 


Asn Gly Lys Ser Gly Ile Ile Leu Gln Ala Glu Ser Arg Lys Glu Asn 
305                 310                 315                 320 


Glu Glu Trp Ile Cys Ala Ile Asn Asn Ile Ser Arg Gln Ile Tyr Leu 
                325                 330                 335     


Xaa Asp Asn Pro Glu Ala Val Ala Ile Lys Leu Asn Gln Xaa Ala Leu 
            340                 345                 350         


Gln Ala Val Xaa Pro Ile Xaa Ser Phe Gly Lys Lys Gln Glu Ser Ser 
        355                 360                 365             


Cys Pro Ser Gln Asn Leu Lys Asn Ser Glu Met Glu Asn Glu Asn Asp 
    370                 375                 380                 


Lys Ile Val Pro Lys Ala Xaa Ala Ser Leu Pro Glu Ala Glu Glu Leu 
385                 390                 395                 400 


Ile Ala Pro Gly Xaa Pro Ile Gln Phe Asp Ile Val Leu Pro Ala Xaa 
                405                 410                 415     


Glu Phe Leu Asp Gln Asn Arg Gly Ser Arg Arg Xaa Asn Pro Phe Gly 
            420                 425                 430         


Glu Xaa Glu Asp Glu Ser Phe Pro Glu Ala Glu Asp Ser Leu Leu Gln 
        435                 440                 445             


Gln Met Phe Ile Val Arg Phe Leu Gly Ser Met Ala Val Lys Xaa Asp 
    450                 455                 460                 


Ser Xaa Xaa Glu Val Ile Tyr Glu Ala Met Arg Gln Val Leu Ala Ala 
465                 470                 475                 480 


Arg Ala Ile His Asn Ile Phe Arg Met Xaa Glu Ser His Leu Met Val 
                485                 490                 495     


Xaa Ser Gln Ser Leu Arg Leu Ile Asp Pro Gln Xaa Gln Val Ser Arg 
            500                 505                 510         


Ala Asn Phe Glu Leu Xaa Ser Val Xaa Gln Phe Ala Ala His Gln Glu 
        515                 520                 525             


Asn Lys Arg Leu Val Gly Phe Val Ile Arg Val Pro Glu Ser Xaa Gly 
    530                 535                 540                 


Glu Glu Ser Leu Ser Xaa Tyr Ile Phe Glu Ser Asn Ser Glu Gly Glu 
545                 550                 555                 560 


Lys Ile Cys Tyr Ala Ile Asn Leu Gly Lys Glu Ile Ile Glu Val Gln 
                565                 570                 575     


Lys Asp Pro Glu Ala Leu Ala Gln Leu Met Leu Ser Ile Pro Leu Xaa 
            580                 585                 590         


Asn Asp Gly Lys Tyr Val Leu Leu Asn Asp Gln Pro Asp Asp Asp Asp 
        595                 600                 605             


Gly Asn Pro Asn Glu His Arg Gly Ala Glu Ser Glu Ala 
    610                 615                 620     


<210> 2639
<211> 107
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 2639
Met Ser Leu Leu Gln Pro Gly Pro Val Phe Pro Ser Gly Asn Ser Glu 
1               5                   10                  15      


Asn Ser Asp Leu Xaa Val Leu Pro Asn His Ile Cys Ser Lys Ile Leu 
            20                  25                  30          


Ser Phe Ser Xaa Phe Ala Asn His Tyr Phe Ser Cys Leu Leu Gln Ile 
        35                  40                  45              


Cys Tyr Ala Ile Asn Leu Gly Lys Glu Ile Ile Glu Val Gln Lys Asp 
    50                  55                  60                  


Pro Glu Ala Leu Ala Gln Leu Met Leu Ser Ile Pro Leu Xaa Asn Asp 
65                  70                  75                  80  


Gly Lys Tyr Val Leu Leu Asn Asp Gln Pro Asp Asp Asp Asp Gly Asn 
                85                  90                  95      


Pro Asn Glu His Arg Gly Ala Glu Ser Glu Ala 
            100                 105         


<210> 2640
<211> 39
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<400> 2640
Met Val Leu Pro Ile Ile Gln Phe Arg Glu Lys Asp Leu Xaa Glu Val 
1               5                   10                  15      


Ser Xaa Leu Lys Asp Leu Phe Gly Leu Ala Ser Asn Ala Gly Cys Leu 
            20                  25                  30          


Arg Lys Arg Arg Met Arg Arg 
        35                  


<210> 2641
<211> 572
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<400> 2641
Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Xaa Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Xaa Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Xaa Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Xaa Leu Ser Leu Leu Gly Pro Xaa Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Xaa Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Xaa Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Xaa Ser Xaa Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Xaa Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Xaa Glu 
    290                 295                 300                 


Asp Xaa Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Xaa Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Xaa Leu Glu Leu Pro Ser Xaa Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Xaa Leu Phe Xaa Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Xaa Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Xaa Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Xaa Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Asn Xaa Arg Arg Lys 
    530                 535                 540                 


Arg Leu Trp Lys Leu Ile Ile Arg Ser Ile Asn Ser Cys Ile Cys Ser 
545                 550                 555                 560 


Pro Arg Glu Xaa Glu Val Pro Val Arg Gln Gln Lys 
                565                 570         


<210> 2642
<211> 600
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<400> 2642
Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Xaa Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Xaa Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Xaa Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Xaa Leu Ser Leu Leu Gly Pro Xaa Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Xaa Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Xaa Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Xaa Ser Xaa Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Xaa Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Xaa Glu 
    290                 295                 300                 


Asp Xaa Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Xaa Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Xaa Leu Glu Leu Pro Ser Xaa Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Xaa Leu Phe Xaa Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Xaa Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Xaa Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Xaa Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Xaa Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Xaa Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Xaa 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Phe Phe 
            580                 585                 590         


Arg Met Asn Lys Leu Lys Glu Ser 
        595                 600 


<210> 2643
<211> 642
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<400> 2643
Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Xaa Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Xaa Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Xaa Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Xaa Leu Ser Leu Leu Gly Pro Xaa Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Xaa Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Xaa Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Xaa Ser Xaa Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Xaa Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Xaa Glu 
    290                 295                 300                 


Asp Xaa Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Xaa Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Xaa Leu Glu Leu Pro Ser Xaa Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Xaa Leu Phe Xaa Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Xaa Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Xaa Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Xaa Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Xaa Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Xaa Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Xaa 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Phe Phe 
            580                 585                 590         


Arg Met Asn Lys Leu Lys Glu Ser Ser Asp Xaa Asn Pro Lys Pro Tyr 
        595                 600                 605             


Cys Met Ala Ala Pro Met Gly Leu Xaa Glu Asn Asn Arg Asn Arg Lys 
    610                 615                 620                 


Lys Ser Tyr Arg Glu Xaa Asn Leu Lys Ala Val Ser Trp Pro Leu Asn 
625                 630                 635                 640 


His Xaa 
        


<210> 2644
<211> 644
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<400> 2644
Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Xaa Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Xaa Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Xaa Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Xaa Leu Ser Leu Leu Gly Pro Xaa Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Xaa Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Xaa Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Xaa Ser Xaa Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Xaa Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Xaa Glu 
    290                 295                 300                 


Asp Xaa Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Xaa Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Xaa Leu Glu Leu Pro Ser Xaa Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Xaa Leu Phe Xaa Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Xaa Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Xaa Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Xaa Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Xaa Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Xaa Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Xaa 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln 
            580                 585                 590         


Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Xaa Ile Asp Lys Phe Arg 
        595                 600                 605             


Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly 
    610                 615                 620                 


Met Xaa Leu Gly Glu Lys Phe Arg Val Gly Asn Cys Lys His Leu Lys 
625                 630                 635                 640 


Met Xaa Arg Pro 
                


<210> 2645
<211> 734
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<400> 2645
Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Xaa Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Xaa Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Xaa Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Xaa Leu Ser Leu Leu Gly Pro Xaa Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Xaa Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Xaa Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Xaa Ser Xaa Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Xaa Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Xaa Glu 
    290                 295                 300                 


Asp Xaa Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Xaa Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Xaa Leu Glu Leu Pro Ser Xaa Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Xaa Leu Phe Xaa Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Xaa Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Xaa Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Xaa Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Xaa Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Xaa Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Xaa 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln 
            580                 585                 590         


Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Xaa Ile Asp Lys Phe Arg 
        595                 600                 605             


Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly 
    610                 615                 620                 


Met Xaa Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu 
625                 630                 635                 640 


Gln Glu Glu Gly Glu Ala Ser Ser Xaa Xaa Ser Pro Xaa Glu Glu Xaa 
                645                 650                 655     


Xaa Gln Lys Leu Xaa Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro 
            660                 665                 670         


Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala 
        675                 680                 685             


Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser 
    690                 695                 700                 


Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala 
705                 710                 715                 720 


Lys Ala Leu Pro Asp Cys Glu Arg Ala Ala Ser Val His Phe 
                725                 730                 


<210> 2646
<211> 920
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<400> 2646
Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Xaa Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Xaa Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Xaa Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Xaa Leu Ser Leu Leu Gly Pro Xaa Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Xaa Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Xaa Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Xaa Ser Xaa Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Xaa Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Xaa Glu 
    290                 295                 300                 


Asp Xaa Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Xaa Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Xaa Leu Glu Leu Pro Ser Xaa Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Xaa Leu Phe Xaa Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Xaa Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Xaa Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Xaa Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Xaa Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Xaa Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Xaa 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln 
            580                 585                 590         


Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Xaa Ile Asp Lys Phe Arg 
        595                 600                 605             


Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly 
    610                 615                 620                 


Met Xaa Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu 
625                 630                 635                 640 


Gln Glu Glu Gly Glu Ala Ser Ser Xaa Xaa Ser Pro Xaa Glu Glu Xaa 
                645                 650                 655     


Xaa Gln Lys Leu Xaa Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro 
            660                 665                 670         


Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala 
        675                 680                 685             


Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser 
    690                 695                 700                 


Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala 
705                 710                 715                 720 


Lys Ala Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala 
                725                 730                 735     


Val Ile Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp 
            740                 745                 750         


Arg Ser Phe Xaa Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp 
        755                 760                 765             


Leu Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln 
    770                 775                 780                 


Cys Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile 
785                 790                 795                 800 


Xaa Pro Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile 
                805                 810                 815     


Ile Pro Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg 
            820                 825                 830         


Met Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys 
        835                 840                 845             


Asn Pro Xaa Ser Cys Ser Arg Arg Phe Tyr Gln Leu Xaa Lys Leu Leu 
    850                 855                 860                 


Asp Ser Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Xaa Phe Asp 
865                 870                 875                 880 


Leu Leu Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met 
                885                 890                 895     


Ala Glu Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val 
            900                 905                 910         


Lys Pro Ile Tyr Phe His Xaa Gln 
        915                 920 


<210> 2647
<211> 388
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<400> 2647
Met Ile Leu Trp Leu His Ser Leu Glu Xaa Ala Arg Asp His Val Leu 
1               5                   10                  15      


Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Xaa Cys Leu Ile Cys Gly 
            20                  25                  30          


Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Xaa Cys Gly Ser Cys 
        35                  40                  45              


Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln Lys Tyr Leu Cys 
    50                  55                  60                  


Ala Ser Arg Asn Asp Cys Xaa Ile Asp Lys Phe Arg Arg Lys Asn Cys 
65                  70                  75                  80  


Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly Met Xaa Leu Gly 
                85                  90                  95      


Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu Gln Glu Glu Gly 
            100                 105                 110         


Glu Ala Ser Ser Xaa Xaa Ser Pro Xaa Glu Glu Xaa Xaa Gln Lys Leu 
        115                 120                 125             


Xaa Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro Ile Phe Leu Asn 
    130                 135                 140                 


Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala Gly His Asp Asn 
145                 150                 155                 160 


Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu Asn Glu Leu 
                165                 170                 175     


Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys Ala Leu Pro 
            180                 185                 190         


Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val Ile Gln Tyr 
        195                 200                 205             


Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg Ser Phe Xaa 
    210                 215                 220                 


Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu Val Phe Asn 
225                 230                 235                 240 


Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys Val Arg Met 
                245                 250                 255     


Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Xaa Pro Gln Glu 
            260                 265                 270         


Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile Pro Val Asp 
        275                 280                 285             


Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met Asn Tyr Ile 
    290                 295                 300                 


Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro Xaa Ser 
305                 310                 315                 320 


Cys Ser Arg Arg Phe Tyr Gln Leu Xaa Lys Leu Leu Asp Ser Val Gln 
                325                 330                 335     


Pro Ile Ala Arg Glu Leu His Gln Phe Xaa Phe Asp Leu Leu Ile Lys 
            340                 345                 350         


Ser His Met Val Ser Val Asp Phe Pro Glu Met Met Ala Glu Ile Ile 
        355                 360                 365             


Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys Pro Ile Tyr 
    370                 375                 380                 


Phe His Xaa Gln 
385             


<210> 2648
<211> 737
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<400> 2648
Met Gln Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser 
1               5                   10                  15      


Ser Ser Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Xaa Ser Ser Lys 
            20                  25                  30          


Asp Asn Tyr Leu Gly Gly Xaa Ser Xaa Ile Ser Asp Asn Ala Lys Glu 
        35                  40                  45              


Leu Cys Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu 
    50                  55                  60                  


Glu His Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala 
65                  70                  75                  80  


Pro Leu Leu Gly Val Pro Pro Ala Val Arg Pro Xaa Pro Cys Ala Pro 
                85                  90                  95      


Leu Ala Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser 
            100                 105                 110         


Xaa Glu Asp Xaa Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Xaa Lys 
        115                 120                 125             


Gly Leu Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly 
    130                 135                 140                 


Ser Ser Gly Xaa Leu Glu Leu Pro Ser Xaa Leu Ser Leu Tyr Lys Ser 
145                 150                 155                 160 


Gly Ala Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn 
                165                 170                 175     


Phe Pro Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His 
            180                 185                 190         


Pro His Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala 
        195                 200                 205             


Trp Ala Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu 
    210                 215                 220                 


His Gly Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala 
225                 230                 235                 240 


Ala Ser Ser Ser Trp His Xaa Leu Phe Xaa Ala Glu Glu Gly Gln Leu 
                245                 250                 255     


Tyr Gly Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            260                 265                 270         


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val 
        275                 280                 285             


Ala Pro Tyr Gly Tyr Xaa Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu 
    290                 295                 300                 


Ser Asp Phe Xaa Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser 
305                 310                 315                 320 


Arg Val Pro Tyr Pro Ser Pro Xaa Cys Val Lys Ser Glu Met Gly Pro 
                325                 330                 335     


Trp Met Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Xaa 
            340                 345                 350         


Ala Arg Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys 
        355                 360                 365             


Xaa Cys Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala 
    370                 375                 380                 


Leu Xaa Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly 
385                 390                 395                 400 


Lys Gln Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Xaa Ile Asp Lys 
                405                 410                 415     


Phe Arg Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu 
            420                 425                 430         


Ala Gly Met Xaa Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu 
        435                 440                 445             


Lys Leu Gln Glu Glu Gly Glu Ala Ser Ser Xaa Xaa Ser Pro Xaa Glu 
    450                 455                 460                 


Glu Xaa Xaa Gln Lys Leu Xaa Val Ser His Ile Glu Gly Tyr Glu Cys 
465                 470                 475                 480 


Gln Pro Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val 
                485                 490                 495     


Cys Ala Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu 
            500                 505                 510         


Ser Ser Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys 
        515                 520                 525             


Trp Ala Lys Ala Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln 
    530                 535                 540                 


Met Ala Val Ile Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met 
545                 550                 555                 560 


Gly Trp Arg Ser Phe Xaa Asn Val Asn Ser Arg Met Leu Tyr Phe Ala 
                565                 570                 575     


Pro Asp Leu Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr 
            580                 585                 590         


Ser Gln Cys Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu 
        595                 600                 605             


Gln Ile Xaa Pro Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe 
    610                 615                 620                 


Ser Ile Lys Ala Asn Leu Phe Ala Arg Ile Pro Val Asp Gly Leu Lys 
625                 630                 635                 640 


Asn Gln Lys Phe Phe Asp Glu Leu Arg Met Asn Tyr Ile Lys Glu Leu 
                645                 650                 655     


Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro Xaa Ser Cys Ser Arg 
            660                 665                 670         


Arg Phe Tyr Gln Leu Xaa Lys Leu Leu Asp Ser Val Gln Pro Ile Ala 
        675                 680                 685             


Arg Glu Leu His Gln Phe Xaa Phe Asp Leu Leu Ile Lys Ser His Met 
    690                 695                 700                 


Val Ser Val Asp Phe Pro Glu Met Met Ala Glu Ile Ile Ser Val Gln 
705                 710                 715                 720 


Val Pro Lys Ile Leu Ser Gly Lys Val Lys Pro Ile Tyr Phe His Xaa 
                725                 730                 735     


Gln 
    


<210> 2649
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<400> 2649
Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg 
1               5                   10                  15      


Ala Val Gly Xaa Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Xaa Val 
            20                  25                  30          


Val Xaa Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala 
        35                  40                  45              


Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu 
    50                  55                  60                  


Ile Lys Gly Arg Lys Xaa Val Xaa Ala Trp Asp Xaa Ala Ile Ala Pro 
65                  70                  75                  80  


Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu 
                85                  90                  95      


Xaa Met His Asn Phe Val Arg Lys Xaa Phe Phe Ser Leu Ala Phe Cys 
            100                 105                 110         


Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Xaa Cys 
        115                 120                 125             


Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Xaa Val Cys 
    130                 135                 140                 


Val Asp Met Ser Xaa Asn Arg Gln Gln Phe Tyr His Ser Val Gln Asp 
145                 150                 155                 160 


Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn Arg Pro Leu 
                165                 170                 175     


Asn Glu Leu Leu Xaa Pro Gln Gly Pro Arg 
            180                 185     


<210> 2650
<211> 606
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<400> 2650
Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg 
1               5                   10                  15      


Ala Val Gly Xaa Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Xaa Val 
            20                  25                  30          


Val Xaa Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala 
        35                  40                  45              


Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu 
    50                  55                  60                  


Ile Lys Gly Arg Lys Xaa Val Xaa Ala Trp Asp Xaa Ala Ile Ala Pro 
65                  70                  75                  80  


Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu 
                85                  90                  95      


Xaa Met His Asn Phe Val Arg Lys Xaa Phe Phe Ser Leu Ala Phe Cys 
            100                 105                 110         


Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Xaa Cys 
        115                 120                 125             


Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Xaa Val Cys 
    130                 135                 140                 


Val Asp Met Ser Xaa Asn Arg Gln Gln Phe Tyr His Ser Val Gln Asp 
145                 150                 155                 160 


Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn Arg Pro Leu 
                165                 170                 175     


Asn Glu Leu Leu Xaa Pro Gln Gly Pro Ser Pro Arg Xaa Gln His Cys 
            180                 185                 190         


Asp Pro Glu His Phe Pro Phe Pro Ala Pro Ala Asn Ala Pro Leu Gln 
        195                 200                 205             


Arg Ile Arg Ser Xaa Ser Xaa Pro Asn Val His Met Val Ser Xaa Xaa 
    210                 215                 220                 


Ala Pro Met Asp Ser Asn Leu Ile Gln Leu Xaa Gly Gln Ser Phe Ser 
225                 230                 235                 240 


Xaa Asp Ala Ala Gly Ser Arg Gly Gly Ser Asp Gly Xaa Pro Arg Gly 
                245                 250                 255     


Ser Pro Ser Pro Ala Ser Val Ser Ser Gly Arg Lys Ser Pro His Ser 
            260                 265                 270         


Lys Ser Pro Ala Glu Gln Arg Glu Arg Lys Ser Leu Ala Asp Asp Lys 
        275                 280                 285             


Lys Lys Val Lys Asn Leu Gly Tyr Arg Asp Ser Gly Tyr Tyr Trp Glu 
    290                 295                 300                 


Val Pro Pro Ser Glu Val Gln Leu Leu Lys Arg Ile Gly Xaa Gly Ser 
305                 310                 315                 320 


Phe Gly Xaa Val Phe Arg Gly Arg Trp His Gly Asp Val Ala Val Lys 
                325                 330                 335     


Val Leu Lys Val Ser Gln Pro Xaa Ala Glu Gln Ala Gln Ala Phe Lys 
            340                 345                 350         


Asn Glu Met Gln Val Leu Arg Lys Xaa Arg His Val Asn Ile Leu Leu 
        355                 360                 365             


Phe Met Gly Phe Met Xaa Arg Pro Gly Phe Ala Ile Ile Xaa Gln Trp 
    370                 375                 380                 


Cys Glu Gly Ser Ser Leu Tyr His His Leu His Val Ala Asp Xaa Arg 
385                 390                 395                 400 


Phe Asp Met Val Gln Leu Ile Asp Val Ala Arg Gln Xaa Ala Gln Gly 
                405                 410                 415     


Met Asp Tyr Leu His Ala Lys Asn Ile Ile His Arg Asp Leu Lys Ser 
            420                 425                 430         


Asn Asn Ile Phe Leu His Glu Gly Leu Xaa Val Lys Ile Gly Asp Phe 
        435                 440                 445             


Gly Leu Ala Xaa Val Lys Xaa Arg Trp Ser Gly Ala Gln Pro Leu Glu 
    450                 455                 460                 


Gln Pro Ser Gly Ser Val Leu Trp Met Ala Ala Glu Val Ile Arg Met 
465                 470                 475                 480 


Gln Asp Pro Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Tyr Gly 
                485                 490                 495     


Val Val Leu Tyr Glu Leu Met Xaa Gly Ser Leu Pro Tyr Ser His Ile 
            500                 505                 510         


Gly Cys Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser 
        515                 520                 525             


Pro Asp Leu Ser Lys Ile Ser Ser Asn Cys Pro Lys Ala Met Arg Arg 
    530                 535                 540                 


Leu Leu Ser Asp Cys Leu Lys Phe Gln Arg Glu Glu Arg Pro Leu Phe 
545                 550                 555                 560 


Pro Gln Ile Leu Ala Xaa Ile Glu Leu Leu Gln Arg Ser Leu Pro Lys 
                565                 570                 575     


Ile Glu Arg Ser Ala Ser Glu Pro Ser Leu His Arg Xaa Gln Ala Asp 
            580                 585                 590         


Glu Leu Pro Ala Cys Leu Leu Ser Ala Ala Arg Leu Val Pro 
        595                 600                 605     


<210> 2651
<211> 609
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<400> 2651
Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg 
1               5                   10                  15      


Ala Val Gly Xaa Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Xaa Val 
            20                  25                  30          


Val Xaa Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala 
        35                  40                  45              


Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu 
    50                  55                  60                  


Ile Lys Gly Arg Lys Xaa Val Xaa Ala Trp Asp Xaa Ala Ile Ala Pro 
65                  70                  75                  80  


Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu 
                85                  90                  95      


Xaa Met His Asn Phe Val Arg Lys Xaa Phe Phe Ser Leu Ala Phe Cys 
            100                 105                 110         


Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Xaa Cys 
        115                 120                 125             


Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Xaa Val Cys 
    130                 135                 140                 


Val Asp Met Ser Xaa Asn Arg Gln Gln Pro Ser Arg Phe Tyr His Ser 
145                 150                 155                 160 


Val Gln Asp Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn 
                165                 170                 175     


Arg Pro Leu Asn Glu Leu Leu Xaa Pro Gln Gly Pro Ser Pro Arg Xaa 
            180                 185                 190         


Gln His Cys Asp Pro Glu His Phe Pro Phe Pro Ala Pro Ala Asn Ala 
        195                 200                 205             


Pro Leu Gln Arg Ile Arg Ser Xaa Ser Xaa Pro Asn Val His Met Val 
    210                 215                 220                 


Ser Xaa Xaa Ala Pro Met Asp Ser Asn Leu Ile Gln Leu Xaa Gly Gln 
225                 230                 235                 240 


Ser Phe Ser Xaa Asp Ala Ala Gly Ser Arg Gly Gly Ser Asp Gly Xaa 
                245                 250                 255     


Pro Arg Gly Ser Pro Ser Pro Ala Ser Val Ser Ser Gly Arg Lys Ser 
            260                 265                 270         


Pro His Ser Lys Ser Pro Ala Glu Gln Arg Glu Arg Lys Ser Leu Ala 
        275                 280                 285             


Asp Asp Lys Lys Lys Val Lys Asn Leu Gly Tyr Arg Asp Ser Gly Tyr 
    290                 295                 300                 


Tyr Trp Glu Val Pro Pro Ser Glu Val Gln Leu Leu Lys Arg Ile Gly 
305                 310                 315                 320 


Xaa Gly Ser Phe Gly Xaa Val Phe Arg Gly Arg Trp His Gly Asp Val 
                325                 330                 335     


Ala Val Lys Val Leu Lys Val Ser Gln Pro Xaa Ala Glu Gln Ala Gln 
            340                 345                 350         


Ala Phe Lys Asn Glu Met Gln Val Leu Arg Lys Xaa Arg His Val Asn 
        355                 360                 365             


Ile Leu Leu Phe Met Gly Phe Met Xaa Arg Pro Gly Phe Ala Ile Ile 
    370                 375                 380                 


Xaa Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Val Ala 
385                 390                 395                 400 


Asp Xaa Arg Phe Asp Met Val Gln Leu Ile Asp Val Ala Arg Gln Xaa 
                405                 410                 415     


Ala Gln Gly Met Asp Tyr Leu His Ala Lys Asn Ile Ile His Arg Asp 
            420                 425                 430         


Leu Lys Ser Asn Asn Ile Phe Leu His Glu Gly Leu Xaa Val Lys Ile 
        435                 440                 445             


Gly Asp Phe Gly Leu Ala Xaa Val Lys Xaa Arg Trp Ser Gly Ala Gln 
    450                 455                 460                 


Pro Leu Glu Gln Pro Ser Gly Ser Val Leu Trp Met Ala Ala Glu Val 
465                 470                 475                 480 


Ile Arg Met Gln Asp Pro Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr 
                485                 490                 495     


Ala Tyr Gly Val Val Leu Tyr Glu Leu Met Xaa Gly Ser Leu Pro Tyr 
            500                 505                 510         


Ser His Ile Gly Cys Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly 
        515                 520                 525             


Tyr Leu Ser Pro Asp Leu Ser Lys Ile Ser Ser Asn Cys Pro Lys Ala 
    530                 535                 540                 


Met Arg Arg Leu Leu Ser Asp Cys Leu Lys Phe Gln Arg Glu Glu Arg 
545                 550                 555                 560 


Pro Leu Phe Pro Gln Ile Leu Ala Xaa Ile Glu Leu Leu Gln Arg Ser 
                565                 570                 575     


Leu Pro Lys Ile Glu Arg Ser Ala Ser Glu Pro Ser Leu His Arg Xaa 
            580                 585                 590         


Gln Ala Asp Glu Leu Pro Ala Cys Leu Leu Ser Ala Ala Arg Leu Val 
        595                 600                 605             


Pro 
    


<210> 2652
<211> 679
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<400> 2652
Ile Asp Ala Ser Gly Lys Gly Glu Phe Ser Arg Arg Trp Cys Val Leu 
1               5                   10                  15      


Gly Asp Gly Val Leu Ser Tyr Phe Glu Asn Glu Arg Ala Val Xaa Pro 
            20                  25                  30          


Asn Gly Glu Ile Arg Ala Ser Glu Ile Val Cys Leu Ala Val Pro Pro 
        35                  40                  45              


Pro Asp Xaa His Gly Phe Glu His Xaa Phe Glu Val Tyr Xaa Glu Gly 
    50                  55                  60                  


Glu Arg Leu Tyr Leu Phe Gly Leu Glu Ser Ala Glu Gln Ala His Glu 
65                  70                  75                  80  


Trp Val Lys Cys Ile Ala Lys Ala Phe Val Pro Pro Leu Ala Glu Asp 
                85                  90                  95      


Leu Leu Ala Arg Asp Phe Glu Arg Leu Gly Arg Leu Pro Tyr Lys Ala 
            100                 105                 110         


Gly Leu Ser Leu Gln Arg Ala Gln Glu Gly Trp Phe Ser Leu Ser Gly 
        115                 120                 125             


Ser Glu Leu Arg Ala Val Phe Pro Glu Gly Pro Cys Glu Glu Pro Leu 
    130                 135                 140                 


Gln Leu Arg Lys Leu Gln Glu Leu Ser Ile Gln Gly Asp Ser Glu Asn 
145                 150                 155                 160 


Gln Val Leu Val Leu Val Glu Arg Arg Arg Xaa Leu Tyr Ile Gln Gly 
                165                 170                 175     


Glu Arg Arg Leu Asp Phe Met Gly Trp Leu Gly Ala Ile Gln Lys Ala 
            180                 185                 190         


Ala Ala Ser Met Gly Asp Xaa Leu Ser Glu Gln Gln Leu Gly Asp Ser 
        195                 200                 205             


Asp Ile Pro Val Ile Val Tyr Arg Cys Val Asp Tyr Ile Xaa Gln Cys 
    210                 215                 220                 


Gly Leu Xaa Ser Glu Gly Ile Tyr Arg Lys Cys Gly Gln Xaa Ser Lys 
225                 230                 235                 240 


Xaa Gln Arg Leu Leu Glu Ser Leu Arg Gln Asp Ala Arg Ser Val His 
                245                 250                 255     


Leu Lys Glu Gly Glu Gln His Val Asp Asp Val Ser Ser Ala Leu Lys 
            260                 265                 270         


Arg Phe Leu Arg Asp Leu Pro Asp Gly Leu Phe Xaa Arg Ala Gln Arg 
        275                 280                 285             


Leu Xaa Trp Leu Glu Ala Ser Glu Ile Glu Asp Glu Glu Glu Lys Val 
    290                 295                 300                 


Ser Arg Tyr Arg Glu Leu Leu Val Arg Leu Pro Pro Val Asn Arg Ala 
305                 310                 315                 320 


Xaa Val Lys Ala Leu Ile Ser His Leu Tyr Cys Val Gln Cys Phe Ser 
                325                 330                 335     


Asp Xaa Asn Gln Met Asn Val His Asn Leu Ala Ile Val Phe Gly Pro 
            340                 345                 350         


Xaa Leu Phe Gln Xaa Asp Gly Gln Asp Tyr Lys Ala Gly Arg Val Val 
        355                 360                 365             


Glu Asp Leu Ile Asn His Tyr Val Val Val Phe Ser Val Asp Glu Glu 
    370                 375                 380                 


Glu Leu Arg Lys Gln Arg Glu Glu Ile Xaa Ala Ile Val Lys Met Arg 
385                 390                 395                 400 


Val Ala Gly Xaa Ala Ser Gly Xaa Gln His Ala Gly Asp Phe Ile Cys 
                405                 410                 415     


Xaa Val Tyr Leu Glu Glu Lys Lys Ala Glu Xaa Glu Gln His Ile Lys 
            420                 425                 430         


Val Pro Ala Ser Met Xaa Ala Glu Glu Leu Xaa Leu Glu Ile Leu Asp 
        435                 440                 445             


Arg Arg Asn Val Gly Ile Arg Glu Lys Asp Tyr Trp Xaa Cys Phe Glu 
    450                 455                 460                 


Val Asn Glu Arg Glu Glu Ala Glu Arg Pro Leu His Phe Ala Glu Lys 
465                 470                 475                 480 


Val Leu Pro Ile Leu His Gly Leu Gly Xaa Asp Ser His Leu Val Val 
                485                 490                 495     


Lys Lys His Gln Ala Met Glu Ala Met Leu Leu Tyr Leu Ala Ser Arg 
            500                 505                 510         


Val Gly Asp Xaa Lys His Gly Met Met Lys Phe Arg Glu Asp Arg Ser 
        515                 520                 525             


Leu Leu Gly Leu Gly Leu Pro Ser Gly Gly Phe His Asp Arg Tyr Phe 
    530                 535                 540                 


Ile Leu Asn Ser Ser Cys Leu Arg Leu Tyr Lys Glu Val Arg Ser His 
545                 550                 555                 560 


Arg Pro Glu Lys Glu Trp Pro Ile Lys Ser Leu Lys Val Tyr Leu Gly 
                565                 570                 575     


Val Lys Lys Lys Leu Arg Pro Pro Xaa Cys Trp Gly Phe Xaa Val Val 
            580                 585                 590         


His Glu Xaa Glu Lys His Glu Lys Gln Gln Trp Tyr Leu Cys Cys Asp 
        595                 600                 605             


Xaa Gln Met Glu Leu Arg Glu Trp Phe Ala Xaa Phe Leu Phe Val Gln 
    610                 615                 620                 


His Asp Gly Leu Val Trp Pro Ser Glu Pro Ser Arg Val Ser Arg Ala 
625                 630                 635                 640 


Val Pro Glu Val Arg Leu Gly Ser Val Ser Leu Ile Pro Leu Arg Gly 
                645                 650                 655     


Ser Glu Asn Glu Met Arg Arg Ser Val Ala Ala Phe Xaa Ala Asp Pro 
            660                 665                 670         


Leu Ser Leu Leu Arg Asn Val 
        675                 


<210> 2653
<211> 1439
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1117)..(1117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1187)..(1187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1221)..(1221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1276)..(1276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1355)..(1355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1369)..(1369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1379)..(1379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1429)..(1429)
<223> Selenocysteine

<400> 2653
Met Ala Glu Ala Gly Asp Ala Ala Leu Ser Val Ala Glu Trp Leu Arg 
1               5                   10                  15      


Ala Leu His Leu Glu Gln Tyr Xaa Gly Leu Phe Glu Gln His Gly Leu 
            20                  25                  30          


Val Trp Ala Xaa Glu Cys Gln Gly Leu Ser Asp Xaa Arg Leu Met Asp 
        35                  40                  45              


Met Gly Met Leu Leu Pro Gly His Arg Arg Arg Ile Leu Ala Gly Leu 
    50                  55                  60                  


Leu Arg Ala His Xaa Ser Pro Ala Pro Ala Pro Arg Pro Xaa Pro Arg 
65                  70                  75                  80  


Pro Val Pro Met Lys Arg His Ile Phe Arg Ser Pro Pro Val Pro Ala 
                85                  90                  95      


Xaa Pro Pro Glu Pro Leu Pro Xaa Xaa Xaa Glu Asp Glu Gly Leu Pro 
            100                 105                 110         


Ala Ala Pro Pro Ile Pro Pro Arg Arg Ser Cys Leu Pro Pro Xaa Cys 
        115                 120                 125             


Phe Xaa Xaa Pro Ser Xaa Ala Ala Pro Asp Pro Val Leu Pro Pro Leu 
    130                 135                 140                 


Pro Ala Lys Arg His Leu Ala Glu Leu Ser Val Pro Pro Val Pro Pro 
145                 150                 155                 160 


Arg Xaa Gly Pro Pro Arg Leu Leu Val Ser Leu Pro Xaa Lys Glu Glu 
                165                 170                 175     


Glu Ser Leu Leu Pro Ser Leu Ser Ser Pro Pro Gln Pro Gln Ser Glu 
            180                 185                 190         


Glu Pro Leu Ser Xaa Leu Pro Gln Gly Pro Pro Gln Pro Pro Ser Pro 
        195                 200                 205             


Pro Pro Cys Pro Pro Glu Ile Pro Pro Lys Pro Val Arg Leu Phe Pro 
    210                 215                 220                 


Glu Phe Asp Asp Ser Asp Tyr Asp Glu Val Pro Glu Glu Gly Pro Gly 
225                 230                 235                 240 


Ala Pro Ala Arg Val Met Xaa Lys Lys Glu Glu Pro Pro Pro Ser Arg 
                245                 250                 255     


Val Pro Arg Ala Val Arg Val Ala Ser Leu Leu Ser Glu Gly Glu Glu 
            260                 265                 270         


Leu Ser Gly Asp Asp Gln Gly Asp Glu Glu Glu Asp Asp His Ala Tyr 
        275                 280                 285             


Glu Gly Val Pro Asn Gly Gly Trp His Xaa Ser Ser Leu Ser Leu Ser 
    290                 295                 300                 


Leu Pro Ser Xaa Ile Ala Ala Pro His Pro Met Asp Gly Pro Pro Gly 
305                 310                 315                 320 


Gly Ser Xaa Pro Val Xaa Pro Val Ile Lys Ala Gly Trp Leu Asp Lys 
                325                 330                 335     


Asn Pro Pro Gln Gly Ser Tyr Ile Tyr Gln Lys Arg Trp Val Arg Leu 
            340                 345                 350         


Asp Xaa Asp His Leu Arg Tyr Phe Asp Ser Asn Lys Asp Ala Tyr Ser 
        355                 360                 365             


Lys Arg Phe Ile Ser Val Ala Cys Ile Ser His Val Ala Ala Ile Gly 
    370                 375                 380                 


Asp Gln Lys Phe Glu Val Ile Xaa Asn Asn Arg Xaa Phe Ala Phe Arg 
385                 390                 395                 400 


Ala Glu Ser Asp Val Glu Arg Lys Glu Trp Met Gln Ala Leu Gln Gln 
                405                 410                 415     


Ala Met Ala Glu Gln Arg Ala Arg Ala Arg Leu Ser Ser Ala Tyr Leu 
            420                 425                 430         


Leu Gly Val Pro Gly Ser Glu Gln Pro Asp Arg Ala Gly Ser Leu Glu 
        435                 440                 445             


Leu Arg Gly Phe Lys Asn Lys Leu Tyr Val Ala Val Val Gly Asp Lys 
    450                 455                 460                 


Val Gln Leu Tyr Lys Asn Leu Glu Glu Tyr His Leu Gly Ile Gly Ile 
465                 470                 475                 480 


Xaa Phe Ile Asp Met Ser Val Gly Asn Val Lys Glu Val Asp Arg Arg 
                485                 490                 495     


Ser Phe Asp Leu Xaa Xaa Pro Tyr Arg Ile Phe Ser Phe Ser Ala Asp 
            500                 505                 510         


Ser Glu Leu Glu Lys Glu Gln Trp Leu Glu Ala Met Gln Gly Ala Ile 
        515                 520                 525             


Ala Glu Ala Leu Ser Xaa Ser Glu Val Ala Glu Arg Ile Trp Ala Ala 
    530                 535                 540                 


Ala Pro Asn Arg Phe Cys Ala Asp Cys Gly Ala Pro Gln Pro Asp Trp 
545                 550                 555                 560 


Ala Ser Ile Asn Leu Cys Val Val Ile Cys Lys Arg Cys Ala Gly Glu 
                565                 570                 575     


His Arg Gly Leu Gly Ala Gly Val Ser Lys Val Arg Ser Leu Lys Met 
            580                 585                 590         


Asp Arg Lys Val Trp Xaa Glu Xaa Leu Ile Glu Leu Phe Leu Gln Leu 
        595                 600                 605             


Gly Asn Gly Ala Gly Asn Arg Phe Trp Ala Ala Asn Val Pro Pro Ser 
    610                 615                 620                 


Glu Ala Leu Gln Pro Ser Ser Ser Pro Ser Xaa Arg Arg Cys His Leu 
625                 630                 635                 640 


Glu Ala Lys Tyr Arg Glu Gly Lys Tyr Arg Arg Tyr His Pro Leu Phe 
                645                 650                 655     


Gly Asn Gln Glu Glu Leu Asp Lys Ala Leu Cys Ala Ala Val Xaa Xaa 
            660                 665                 670         


Xaa Asp Leu Ala Glu Xaa Gln Ala Leu Leu Gly Cys Gly Ala Gly Ile 
        675                 680                 685             


Asn Cys Phe Ser Gly Asp Pro Glu Ala Pro Xaa Pro Leu Ala Leu Ala 
    690                 695                 700                 


Glu Gln Ala Gly Gln Xaa Leu Gln Met Glu Phe Leu Arg Asn Asn Arg 
705                 710                 715                 720 


Xaa Xaa Glu Val Pro Arg Leu Asp Ser Met Lys Pro Leu Glu Lys His 
                725                 730                 735     


Tyr Ser Val Val Leu Pro Xaa Val Ser His Ser Gly Phe Leu Tyr Lys 
            740                 745                 750         


Xaa Ala Ser Ala Gly Lys Leu Leu Gln Asp Arg Arg Ala Arg Glu Glu 
        755                 760                 765             


Phe Ser Arg Arg Trp Cys Val Leu Gly Asp Gly Val Leu Ser Tyr Phe 
    770                 775                 780                 


Glu Asn Glu Arg Ala Val Xaa Pro Asn Gly Glu Ile Arg Ala Ser Glu 
785                 790                 795                 800 


Ile Val Cys Leu Ala Val Pro Pro Pro Asp Xaa His Gly Phe Glu His 
                805                 810                 815     


Xaa Phe Glu Val Tyr Xaa Glu Gly Glu Arg Leu Tyr Leu Phe Gly Leu 
            820                 825                 830         


Glu Ser Ala Glu Gln Ala His Glu Trp Val Lys Cys Ile Ala Lys Ala 
        835                 840                 845             


Phe Val Pro Pro Leu Ala Glu Asp Leu Leu Ala Arg Asp Phe Glu Arg 
    850                 855                 860                 


Leu Gly Arg Leu Pro Tyr Lys Ala Gly Leu Ser Leu Gln Arg Ala Gln 
865                 870                 875                 880 


Glu Gly Trp Phe Ser Leu Ser Gly Ser Glu Leu Arg Ala Val Phe Pro 
                885                 890                 895     


Glu Gly Pro Cys Glu Glu Pro Leu Gln Leu Arg Lys Leu Gln Glu Leu 
            900                 905                 910         


Ser Ile Gln Gly Asp Ser Glu Asn Gln Val Leu Val Leu Val Glu Arg 
        915                 920                 925             


Arg Arg Xaa Leu Tyr Ile Gln Gly Glu Arg Arg Leu Asp Phe Met Gly 
    930                 935                 940                 


Trp Leu Gly Ala Ile Gln Lys Ala Ala Ala Ser Met Gly Asp Xaa Leu 
945                 950                 955                 960 


Ser Glu Gln Gln Leu Gly Asp Ser Asp Ile Pro Val Ile Val Tyr Arg 
                965                 970                 975     


Cys Val Asp Tyr Ile Xaa Gln Cys Gly Leu Xaa Ser Glu Gly Ile Tyr 
            980                 985                 990         


Arg Lys Cys Gly Gln Xaa Ser Lys  Xaa Gln Arg Leu Leu  Glu Ser Leu 
        995                 1000                 1005             


Arg Gln  Asp Ala Arg Ser Val  His Leu Lys Glu Gly  Glu Gln His 
    1010                 1015                 1020             


Val Asp  Asp Val Ser Ser Ala  Leu Lys Arg Phe Leu  Arg Asp Leu 
    1025                 1030                 1035             


Pro Asp  Gly Leu Phe Xaa Arg  Ala Gln Arg Leu Xaa  Trp Leu Glu 
    1040                 1045                 1050             


Ala Ser  Glu Ile Glu Asp Glu  Glu Glu Lys Val Ser  Arg Tyr Arg 
    1055                 1060                 1065             


Glu Leu  Leu Val Arg Leu Pro  Pro Val Asn Arg Ala  Xaa Val Lys 
    1070                 1075                 1080             


Ala Leu  Ile Ser His Leu Tyr  Cys Val Gln Cys Phe  Ser Asp Xaa 
    1085                 1090                 1095             


Asn Gln  Met Asn Val His Asn  Leu Ala Ile Val Phe  Gly Pro Xaa 
    1100                 1105                 1110             


Leu Phe  Gln Xaa Asp Gly Gln  Asp Tyr Lys Ala Gly  Arg Val Val 
    1115                 1120                 1125             


Glu Asp  Leu Ile Asn His Tyr  Val Val Val Phe Ser  Val Asp Glu 
    1130                 1135                 1140             


Glu Glu  Leu Arg Lys Gln Arg  Glu Glu Ile Xaa Ala  Ile Val Lys 
    1145                 1150                 1155             


Met Arg  Val Ala Gly Xaa Ala  Ser Gly Xaa Gln His  Ala Gly Asp 
    1160                 1165                 1170             


Phe Ile  Cys Xaa Val Tyr Leu  Glu Glu Lys Lys Ala  Glu Xaa Glu 
    1175                 1180                 1185             


Gln His  Ile Lys Val Pro Ala  Ser Met Xaa Ala Glu  Glu Leu Xaa 
    1190                 1195                 1200             


Leu Glu  Ile Leu Asp Arg Arg  Asn Val Gly Ile Arg  Glu Lys Asp 
    1205                 1210                 1215             


Tyr Trp  Xaa Cys Phe Glu Val  Asn Glu Arg Glu Glu  Ala Glu Arg 
    1220                 1225                 1230             


Pro Leu  His Phe Ala Glu Lys  Val Leu Pro Ile Leu  His Gly Leu 
    1235                 1240                 1245             


Gly Xaa  Asp Ser His Leu Val  Val Lys Lys His Gln  Ala Met Glu 
    1250                 1255                 1260             


Ala Met  Leu Leu Tyr Leu Ala  Ser Arg Val Gly Asp  Xaa Lys His 
    1265                 1270                 1275             


Gly Met  Met Lys Phe Arg Glu  Asp Arg Ser Leu Leu  Gly Leu Gly 
    1280                 1285                 1290             


Leu Pro  Ser Gly Gly Phe His  Asp Arg Tyr Phe Ile  Leu Asn Ser 
    1295                 1300                 1305             


Ser Cys  Leu Arg Leu Tyr Lys  Glu Val Arg Ser His  Arg Pro Glu 
    1310                 1315                 1320             


Lys Glu  Trp Pro Ile Lys Ser  Leu Lys Val Tyr Leu  Gly Val Lys 
    1325                 1330                 1335             


Lys Lys  Leu Arg Pro Pro Xaa  Cys Trp Gly Phe Xaa  Val Val His 
    1340                 1345                 1350             


Glu Xaa  Glu Lys His Glu Lys  Gln Gln Trp Tyr Leu  Cys Cys Asp 
    1355                 1360                 1365             


Xaa Gln  Met Glu Leu Arg Glu  Trp Phe Ala Xaa Phe  Leu Phe Val 
    1370                 1375                 1380             


Gln His  Asp Gly Leu Val Trp  Pro Ser Glu Pro Ser  Arg Val Ser 
    1385                 1390                 1395             


Arg Ala  Val Pro Glu Val Arg  Leu Gly Ser Val Ser  Leu Ile Pro 
    1400                 1405                 1410             


Leu Arg  Gly Ser Glu Asn Glu  Met Arg Arg Ser Val  Ala Ala Phe 
    1415                 1420                 1425             


Xaa Ala  Asp Pro Leu Ser Leu  Leu Arg Asn Val 
    1430                 1435                 


<210> 2654
<211> 1450
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1117)..(1117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1187)..(1187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1221)..(1221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1276)..(1276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1356)..(1356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1361)..(1361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1366)..(1366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1380)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1440)..(1440)
<223> Selenocysteine

<400> 2654
Met Ala Glu Ala Gly Asp Ala Ala Leu Ser Val Ala Glu Trp Leu Arg 
1               5                   10                  15      


Ala Leu His Leu Glu Gln Tyr Xaa Gly Leu Phe Glu Gln His Gly Leu 
            20                  25                  30          


Val Trp Ala Xaa Glu Cys Gln Gly Leu Ser Asp Xaa Arg Leu Met Asp 
        35                  40                  45              


Met Gly Met Leu Leu Pro Gly His Arg Arg Arg Ile Leu Ala Gly Leu 
    50                  55                  60                  


Leu Arg Ala His Xaa Ser Pro Ala Pro Ala Pro Arg Pro Xaa Pro Arg 
65                  70                  75                  80  


Pro Val Pro Met Lys Arg His Ile Phe Arg Ser Pro Pro Val Pro Ala 
                85                  90                  95      


Xaa Pro Pro Glu Pro Leu Pro Xaa Xaa Xaa Glu Asp Glu Gly Leu Pro 
            100                 105                 110         


Ala Ala Pro Pro Ile Pro Pro Arg Arg Ser Cys Leu Pro Pro Xaa Cys 
        115                 120                 125             


Phe Xaa Xaa Pro Ser Xaa Ala Ala Pro Asp Pro Val Leu Pro Pro Leu 
    130                 135                 140                 


Pro Ala Lys Arg His Leu Ala Glu Leu Ser Val Pro Pro Val Pro Pro 
145                 150                 155                 160 


Arg Xaa Gly Pro Pro Arg Leu Leu Val Ser Leu Pro Xaa Lys Glu Glu 
                165                 170                 175     


Glu Ser Leu Leu Pro Ser Leu Ser Ser Pro Pro Gln Pro Gln Ser Glu 
            180                 185                 190         


Glu Pro Leu Ser Xaa Leu Pro Gln Gly Pro Pro Gln Pro Pro Ser Pro 
        195                 200                 205             


Pro Pro Cys Pro Pro Glu Ile Pro Pro Lys Pro Val Arg Leu Phe Pro 
    210                 215                 220                 


Glu Phe Asp Asp Ser Asp Tyr Asp Glu Val Pro Glu Glu Gly Pro Gly 
225                 230                 235                 240 


Ala Pro Ala Arg Val Met Xaa Lys Lys Glu Glu Pro Pro Pro Ser Arg 
                245                 250                 255     


Val Pro Arg Ala Val Arg Val Ala Ser Leu Leu Ser Glu Gly Glu Glu 
            260                 265                 270         


Leu Ser Gly Asp Asp Gln Gly Asp Glu Glu Glu Asp Asp His Ala Tyr 
        275                 280                 285             


Glu Gly Val Pro Asn Gly Gly Trp His Xaa Ser Ser Leu Ser Leu Ser 
    290                 295                 300                 


Leu Pro Ser Xaa Ile Ala Ala Pro His Pro Met Asp Gly Pro Pro Gly 
305                 310                 315                 320 


Gly Ser Xaa Pro Val Xaa Pro Val Ile Lys Ala Gly Trp Leu Asp Lys 
                325                 330                 335     


Asn Pro Pro Gln Gly Ser Tyr Ile Tyr Gln Lys Arg Trp Val Arg Leu 
            340                 345                 350         


Asp Xaa Asp His Leu Arg Tyr Phe Asp Ser Asn Lys Asp Ala Tyr Ser 
        355                 360                 365             


Lys Arg Phe Ile Ser Val Ala Cys Ile Ser His Val Ala Ala Ile Gly 
    370                 375                 380                 


Asp Gln Lys Phe Glu Val Ile Xaa Asn Asn Arg Xaa Phe Ala Phe Arg 
385                 390                 395                 400 


Ala Glu Ser Asp Val Glu Arg Lys Glu Trp Met Gln Ala Leu Gln Gln 
                405                 410                 415     


Ala Met Ala Glu Gln Arg Ala Arg Ala Arg Leu Ser Ser Ala Tyr Leu 
            420                 425                 430         


Leu Gly Val Pro Gly Ser Glu Gln Pro Asp Arg Ala Gly Ser Leu Glu 
        435                 440                 445             


Leu Arg Gly Phe Lys Asn Lys Leu Tyr Val Ala Val Val Gly Asp Lys 
    450                 455                 460                 


Val Gln Leu Tyr Lys Asn Leu Glu Glu Tyr His Leu Gly Ile Gly Ile 
465                 470                 475                 480 


Xaa Phe Ile Asp Met Ser Val Gly Asn Val Lys Glu Val Asp Arg Arg 
                485                 490                 495     


Ser Phe Asp Leu Xaa Xaa Pro Tyr Arg Ile Phe Ser Phe Ser Ala Asp 
            500                 505                 510         


Ser Glu Leu Glu Lys Glu Gln Trp Leu Glu Ala Met Gln Gly Ala Ile 
        515                 520                 525             


Ala Glu Ala Leu Ser Xaa Ser Glu Val Ala Glu Arg Ile Trp Ala Ala 
    530                 535                 540                 


Ala Pro Asn Arg Phe Cys Ala Asp Cys Gly Ala Pro Gln Pro Asp Trp 
545                 550                 555                 560 


Ala Ser Ile Asn Leu Cys Val Val Ile Cys Lys Arg Cys Ala Gly Glu 
                565                 570                 575     


His Arg Gly Leu Gly Ala Gly Val Ser Lys Val Arg Ser Leu Lys Met 
            580                 585                 590         


Asp Arg Lys Val Trp Xaa Glu Xaa Leu Ile Glu Leu Phe Leu Gln Leu 
        595                 600                 605             


Gly Asn Gly Ala Gly Asn Arg Phe Trp Ala Ala Asn Val Pro Pro Ser 
    610                 615                 620                 


Glu Ala Leu Gln Pro Ser Ser Ser Pro Ser Xaa Arg Arg Cys His Leu 
625                 630                 635                 640 


Glu Ala Lys Tyr Arg Glu Gly Lys Tyr Arg Arg Tyr His Pro Leu Phe 
                645                 650                 655     


Gly Asn Gln Glu Glu Leu Asp Lys Ala Leu Cys Ala Ala Val Xaa Xaa 
            660                 665                 670         


Xaa Asp Leu Ala Glu Xaa Gln Ala Leu Leu Gly Cys Gly Ala Gly Ile 
        675                 680                 685             


Asn Cys Phe Ser Gly Asp Pro Glu Ala Pro Xaa Pro Leu Ala Leu Ala 
    690                 695                 700                 


Glu Gln Ala Gly Gln Xaa Leu Gln Met Glu Phe Leu Arg Asn Asn Arg 
705                 710                 715                 720 


Xaa Xaa Glu Val Pro Arg Leu Asp Ser Met Lys Pro Leu Glu Lys His 
                725                 730                 735     


Tyr Ser Val Val Leu Pro Xaa Val Ser His Ser Gly Phe Leu Tyr Lys 
            740                 745                 750         


Xaa Ala Ser Ala Gly Lys Leu Leu Gln Asp Arg Arg Ala Arg Glu Glu 
        755                 760                 765             


Phe Ser Arg Arg Trp Cys Val Leu Gly Asp Gly Val Leu Ser Tyr Phe 
    770                 775                 780                 


Glu Asn Glu Arg Ala Val Xaa Pro Asn Gly Glu Ile Arg Ala Ser Glu 
785                 790                 795                 800 


Ile Val Cys Leu Ala Val Pro Pro Pro Asp Xaa His Gly Phe Glu His 
                805                 810                 815     


Xaa Phe Glu Val Tyr Xaa Glu Gly Glu Arg Leu Tyr Leu Phe Gly Leu 
            820                 825                 830         


Glu Ser Ala Glu Gln Ala His Glu Trp Val Lys Cys Ile Ala Lys Ala 
        835                 840                 845             


Phe Val Pro Pro Leu Ala Glu Asp Leu Leu Ala Arg Asp Phe Glu Arg 
    850                 855                 860                 


Leu Gly Arg Leu Pro Tyr Lys Ala Gly Leu Ser Leu Gln Arg Ala Gln 
865                 870                 875                 880 


Glu Gly Trp Phe Ser Leu Ser Gly Ser Glu Leu Arg Ala Val Phe Pro 
                885                 890                 895     


Glu Gly Pro Cys Glu Glu Pro Leu Gln Leu Arg Lys Leu Gln Glu Leu 
            900                 905                 910         


Ser Ile Gln Gly Asp Ser Glu Asn Gln Val Leu Val Leu Val Glu Arg 
        915                 920                 925             


Arg Arg Xaa Leu Tyr Ile Gln Gly Glu Arg Arg Leu Asp Phe Met Gly 
    930                 935                 940                 


Trp Leu Gly Ala Ile Gln Lys Ala Ala Ala Ser Met Gly Asp Xaa Leu 
945                 950                 955                 960 


Ser Glu Gln Gln Leu Gly Asp Ser Asp Ile Pro Val Ile Val Tyr Arg 
                965                 970                 975     


Cys Val Asp Tyr Ile Xaa Gln Cys Gly Leu Xaa Ser Glu Gly Ile Tyr 
            980                 985                 990         


Arg Lys Cys Gly Gln Xaa Ser Lys  Xaa Gln Arg Leu Leu  Glu Ser Leu 
        995                 1000                 1005             


Arg Gln  Asp Ala Arg Ser Val  His Leu Lys Glu Gly  Glu Gln His 
    1010                 1015                 1020             


Val Asp  Asp Val Ser Ser Ala  Leu Lys Arg Phe Leu  Arg Asp Leu 
    1025                 1030                 1035             


Pro Asp  Gly Leu Phe Xaa Arg  Ala Gln Arg Leu Xaa  Trp Leu Glu 
    1040                 1045                 1050             


Ala Ser  Glu Ile Glu Asp Glu  Glu Glu Lys Val Ser  Arg Tyr Arg 
    1055                 1060                 1065             


Glu Leu  Leu Val Arg Leu Pro  Pro Val Asn Arg Ala  Xaa Val Lys 
    1070                 1075                 1080             


Ala Leu  Ile Ser His Leu Tyr  Cys Val Gln Cys Phe  Ser Asp Xaa 
    1085                 1090                 1095             


Asn Gln  Met Asn Val His Asn  Leu Ala Ile Val Phe  Gly Pro Xaa 
    1100                 1105                 1110             


Leu Phe  Gln Xaa Asp Gly Gln  Asp Tyr Lys Ala Gly  Arg Val Val 
    1115                 1120                 1125             


Glu Asp  Leu Ile Asn His Tyr  Val Val Val Phe Ser  Val Asp Glu 
    1130                 1135                 1140             


Glu Glu  Leu Arg Lys Gln Arg  Glu Glu Ile Xaa Ala  Ile Val Lys 
    1145                 1150                 1155             


Met Arg  Val Ala Gly Xaa Ala  Ser Gly Xaa Gln His  Ala Gly Asp 
    1160                 1165                 1170             


Phe Ile  Cys Xaa Val Tyr Leu  Glu Glu Lys Lys Ala  Glu Xaa Glu 
    1175                 1180                 1185             


Gln His  Ile Lys Val Pro Ala  Ser Met Xaa Ala Glu  Glu Leu Xaa 
    1190                 1195                 1200             


Leu Glu  Ile Leu Asp Arg Arg  Asn Val Gly Ile Arg  Glu Lys Asp 
    1205                 1210                 1215             


Tyr Trp  Xaa Cys Phe Glu Val  Asn Glu Arg Glu Glu  Ala Glu Arg 
    1220                 1225                 1230             


Pro Leu  His Phe Ala Glu Lys  Val Leu Pro Ile Leu  His Gly Leu 
    1235                 1240                 1245             


Gly Xaa  Asp Ser His Leu Val  Val Lys Lys His Gln  Ala Met Glu 
    1250                 1255                 1260             


Ala Met  Leu Leu Tyr Leu Ala  Ser Arg Val Gly Asp  Xaa Lys His 
    1265                 1270                 1275             


Gly Met  Met Lys Phe Arg Glu  Asp Arg Ser Leu Leu  Gly Leu Gly 
    1280                 1285                 1290             


Leu Pro  Ser Gly Gly Phe His  Asp Arg Tyr Phe Ile  Leu Asn Ser 
    1295                 1300                 1305             


Ser Cys  Leu Arg Leu Tyr Lys  Glu Val Arg Ser Gln  Arg Pro Trp 
    1310                 1315                 1320             


Ser Gly  Ala Pro Glu Xaa Ser  His Arg Pro Glu Lys  Glu Trp Pro 
    1325                 1330                 1335             


Ile Lys  Ser Leu Lys Val Tyr  Leu Gly Val Lys Lys  Lys Leu Arg 
    1340                 1345                 1350             


Pro Pro  Xaa Cys Trp Gly Phe  Xaa Val Val His Glu  Xaa Glu Lys 
    1355                 1360                 1365             


His Glu  Lys Gln Gln Trp Tyr  Leu Cys Cys Asp Xaa  Gln Met Glu 
    1370                 1375                 1380             


Leu Arg  Glu Trp Phe Ala Xaa  Phe Leu Phe Val Gln  His Asp Gly 
    1385                 1390                 1395             


Leu Val  Trp Pro Ser Glu Pro  Ser Arg Val Ser Arg  Ala Val Pro 
    1400                 1405                 1410             


Glu Val  Arg Leu Gly Ser Val  Ser Leu Ile Pro Leu  Arg Gly Ser 
    1415                 1420                 1425             


Glu Asn  Glu Met Arg Arg Ser  Val Ala Ala Phe Xaa  Ala Asp Pro 
    1430                 1435                 1440             


Leu Ser  Leu Leu Arg Asn Val  
    1445                 1450 


<210> 2655
<211> 254
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<400> 2655
Met Glu Phe Leu Arg Asn Asn Arg Xaa Xaa Glu Val Pro Arg Leu Asp 
1               5                   10                  15      


Ser Met Lys Pro Leu Glu Lys His Tyr Ser Val Val Leu Pro Xaa Val 
            20                  25                  30          


Ser His Ser Gly Phe Leu Tyr Lys Xaa Ala Ser Ala Gly Lys Leu Leu 
        35                  40                  45              


Gln Asp Arg Arg Ala Arg Glu Glu Phe Ser Arg Arg Trp Cys Val Leu 
    50                  55                  60                  


Gly Asp Gly Val Leu Ser Tyr Phe Glu Asn Glu Arg Ala Val Xaa Pro 
65                  70                  75                  80  


Asn Gly Glu Ile Arg Ala Ser Glu Ile Val Cys Leu Ala Val Pro Pro 
                85                  90                  95      


Pro Asp Xaa His Gly Phe Glu His Xaa Phe Glu Val Tyr Xaa Glu Gly 
            100                 105                 110         


Glu Arg Leu Tyr Leu Phe Gly Leu Glu Ser Ala Glu Gln Ala His Glu 
        115                 120                 125             


Trp Val Lys Cys Ile Ala Lys Ala Phe Val Pro Pro Leu Ala Glu Asp 
    130                 135                 140                 


Leu Leu Ala Arg Asp Phe Glu Arg Leu Gly Arg Leu Pro Tyr Lys Ala 
145                 150                 155                 160 


Gly Leu Ser Leu Gln Arg Ala Gln Glu Gly Trp Phe Ser Leu Ser Gly 
                165                 170                 175     


Ser Glu Leu Arg Ala Val Phe Pro Glu Gly Pro Cys Glu Glu Pro Leu 
            180                 185                 190         


Gln Leu Arg Lys Leu Gln Glu Leu Ser Ile Gln Gly Asp Ser Glu Asn 
        195                 200                 205             


Gln Val Leu Val Leu Val Glu Arg Arg Arg Xaa Leu Tyr Ile Gln Gly 
    210                 215                 220                 


Glu Arg Arg Leu Asp Phe Met Gly Trp Leu Gly Ala Ile Gln Lys Ala 
225                 230                 235                 240 


Ala Ala Ser Met Gly Asp Xaa Leu Ser Glu Gln Gln Leu Gly 
                245                 250                 


<210> 2656
<211> 307
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<400> 2656
Met Glu Phe Leu Arg Asn Asn Arg Xaa Xaa Glu Val Pro Arg Leu Asp 
1               5                   10                  15      


Ser Met Lys Pro Leu Glu Lys His Tyr Ser Val Val Leu Pro Xaa Val 
            20                  25                  30          


Ser His Ser Gly Phe Leu Tyr Lys Xaa Ala Ser Ala Gly Lys Leu Leu 
        35                  40                  45              


Gln Asp Arg Arg Ala Arg Glu Glu Phe Ser Arg Arg Trp Cys Val Leu 
    50                  55                  60                  


Gly Asp Gly Val Leu Ser Tyr Phe Glu Asn Glu Arg Ala Val Xaa Pro 
65                  70                  75                  80  


Asn Gly Glu Ile Arg Ala Ser Glu Ile Val Cys Leu Ala Val Pro Pro 
                85                  90                  95      


Pro Asp Xaa His Gly Phe Glu His Xaa Phe Glu Val Tyr Xaa Glu Gly 
            100                 105                 110         


Glu Arg Leu Tyr Leu Phe Gly Leu Glu Ser Ala Glu Gln Ala His Glu 
        115                 120                 125             


Trp Val Lys Cys Ile Ala Lys Ala Phe Val Pro Pro Leu Ala Glu Asp 
    130                 135                 140                 


Leu Leu Ala Arg Asp Phe Glu Arg Leu Gly Arg Leu Pro Tyr Lys Ala 
145                 150                 155                 160 


Gly Leu Ser Leu Gln Arg Ala Gln Glu Gly Trp Phe Ser Leu Ser Gly 
                165                 170                 175     


Ser Glu Leu Arg Ala Val Phe Pro Glu Gly Pro Cys Glu Glu Pro Leu 
            180                 185                 190         


Gln Leu Arg Lys Leu Gln Glu Leu Ser Ile Gln Gly Asp Ser Glu Asn 
        195                 200                 205             


Gln Val Leu Val Leu Val Glu Arg Arg Arg Xaa Leu Tyr Ile Gln Gly 
    210                 215                 220                 


Glu Arg Arg Leu Asp Phe Met Gly Trp Leu Gly Ala Ile Gln Lys Ala 
225                 230                 235                 240 


Ala Ala Ser Met Gly Asp Xaa Leu Ser Glu Gln Gln Leu Gly Asp Ser 
                245                 250                 255     


Asp Ile Pro Val Ile Val Tyr Arg Cys Val Asp Tyr Ile Xaa Gln Cys 
            260                 265                 270         


Gly Leu Xaa Ser Glu Gly Ile Tyr Arg Lys Cys Gly Gln Xaa Ser Lys 
        275                 280                 285             


Xaa Gln Arg Leu Leu Glu Ser Leu Arg Gln Asp Ala Arg Ser Val His 
    290                 295                 300                 


Leu Lys Glu 
305         


<210> 2657
<211> 233
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<400> 2657
Met Xaa Ala Glu Glu Leu Xaa Leu Glu Ile Leu Asp Arg Arg Asn Val 
1               5                   10                  15      


Gly Ile Arg Glu Lys Asp Tyr Trp Xaa Cys Phe Glu Val Asn Glu Arg 
            20                  25                  30          


Glu Glu Ala Glu Arg Pro Leu His Phe Ala Glu Lys Val Leu Pro Ile 
        35                  40                  45              


Leu His Gly Leu Gly Xaa Asp Ser His Leu Val Val Lys Lys His Gln 
    50                  55                  60                  


Ala Met Glu Ala Met Leu Leu Tyr Leu Ala Ser Arg Val Gly Asp Xaa 
65                  70                  75                  80  


Lys His Gly Met Met Lys Phe Arg Glu Asp Arg Ser Leu Leu Gly Leu 
                85                  90                  95      


Gly Leu Pro Ser Gly Gly Phe His Asp Arg Tyr Phe Ile Leu Asn Ser 
            100                 105                 110         


Ser Cys Leu Arg Leu Tyr Lys Glu Val Arg Ser His Arg Pro Glu Lys 
        115                 120                 125             


Glu Trp Pro Ile Lys Ser Leu Lys Val Tyr Leu Gly Val Lys Lys Lys 
    130                 135                 140                 


Leu Arg Pro Pro Xaa Cys Trp Gly Phe Xaa Val Val His Glu Xaa Glu 
145                 150                 155                 160 


Lys His Glu Lys Gln Gln Trp Tyr Leu Cys Cys Asp Xaa Gln Met Glu 
                165                 170                 175     


Leu Arg Glu Trp Phe Ala Xaa Phe Leu Phe Val Gln His Asp Gly Leu 
            180                 185                 190         


Val Trp Pro Ser Glu Pro Ser Arg Val Ser Arg Ala Val Pro Glu Val 
        195                 200                 205             


Arg Leu Gly Ser Val Ser Leu Ile Pro Leu Arg Gly Xaa Ser Ala Gln 
    210                 215                 220                 


Arg Leu Ser Xaa Gly Ala His Pro Trp 
225                 230             


<210> 2658
<211> 1133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1123)..(1123)
<223> Selenocysteine

<400> 2658
Met Xaa Lys Lys Glu Glu Pro Pro Pro Ser Arg Val Pro Arg Ala Val 
1               5                   10                  15      


Arg Val Ala Ser Leu Leu Ser Glu Gly Glu Glu Leu Ser Gly Asp Asp 
            20                  25                  30          


Gln Gly Asp Glu Glu Glu Asp Asp His Ala Tyr Glu Gly Val Pro Asn 
        35                  40                  45              


Gly Gly Trp His Xaa Ser Ser Leu Ser Leu Ser Leu Pro Ser Xaa Ile 
    50                  55                  60                  


Ala Ala Pro His Pro Met Asp Gly Pro Pro Gly Gly Ser Xaa Pro Val 
65                  70                  75                  80  


Xaa Pro Val Ile Lys Ala Gly Trp Leu Asp Lys Asn Pro Pro Gln Gly 
                85                  90                  95      


Ser Tyr Ile Tyr Gln Lys Arg Trp Val Arg Leu Asp Xaa Asp His Leu 
            100                 105                 110         


Arg Tyr Phe Asp Ser Asn Lys Asp Ala Tyr Ser Lys Arg Phe Ile Ser 
        115                 120                 125             


Val Ala Cys Ile Ser His Val Ala Ala Ile Gly Asp Gln Lys Phe Glu 
    130                 135                 140                 


Val Ile Xaa Asn Asn Arg Xaa Phe Ala Phe Arg Ala Glu Ser Asp Val 
145                 150                 155                 160 


Glu Arg Lys Glu Trp Met Gln Ala Leu Gln Gln Ala Met Ala Glu Gln 
                165                 170                 175     


Arg Ala Arg Ala Arg Leu Ser Ser Ala Tyr Leu Leu Gly Val Pro Gly 
            180                 185                 190         


Ser Glu Gln Pro Asp Arg Ala Gly Ser Leu Glu Leu Arg Gly Phe Lys 
        195                 200                 205             


Asn Lys Leu Tyr Val Ala Val Val Gly Asp Lys Val Gln Leu Tyr Lys 
    210                 215                 220                 


Asn Leu Glu Glu Tyr His Leu Gly Ile Gly Ile Xaa Phe Ile Asp Met 
225                 230                 235                 240 


Ser Val Gly Asn Val Lys Glu Val Asp Arg Arg Ser Phe Asp Leu Xaa 
                245                 250                 255     


Xaa Pro Tyr Arg Ile Phe Ser Phe Ser Ala Asp Ser Glu Leu Glu Lys 
            260                 265                 270         


Glu Gln Trp Leu Glu Ala Met Gln Gly Ala Ile Ala Glu Ala Leu Ser 
        275                 280                 285             


Xaa Ser Glu Val Ala Glu Arg Ile Trp Ala Ala Ala Pro Asn Arg Phe 
    290                 295                 300                 


Cys Ala Asp Cys Gly Ala Pro Gln Pro Asp Trp Ala Ser Ile Asn Leu 
305                 310                 315                 320 


Cys Val Val Ile Cys Lys Arg Cys Ala Gly Glu His Arg Gly Leu Gly 
                325                 330                 335     


Ala Gly Val Ser Lys Val Arg Ser Leu Lys Met Asp Arg Lys Val Trp 
            340                 345                 350         


Xaa Glu Xaa Leu Ile Glu Ala Leu Cys Ala Ala Val Xaa Xaa Xaa Asp 
        355                 360                 365             


Leu Ala Glu Xaa Gln Ala Leu Leu Gly Cys Gly Ala Gly Ile Asn Cys 
    370                 375                 380                 


Phe Ser Gly Asp Pro Glu Ala Pro Xaa Pro Leu Ala Leu Ala Glu Gln 
385                 390                 395                 400 


Ala Gly Gln Xaa Leu Gln Met Glu Phe Leu Arg Asn Asn Arg Xaa Xaa 
                405                 410                 415     


Glu Val Pro Arg Leu Asp Ser Met Lys Pro Leu Glu Lys His Tyr Ser 
            420                 425                 430         


Val Val Leu Pro Xaa Val Ser His Ser Gly Phe Leu Tyr Lys Xaa Ala 
        435                 440                 445             


Ser Ala Gly Lys Leu Leu Gln Asp Arg Arg Ala Arg Glu Glu Phe Ser 
    450                 455                 460                 


Arg Arg Trp Cys Val Leu Gly Asp Gly Val Leu Ser Tyr Phe Glu Asn 
465                 470                 475                 480 


Glu Arg Ala Val Xaa Pro Asn Gly Glu Ile Arg Ala Ser Glu Ile Val 
                485                 490                 495     


Cys Leu Ala Val Pro Pro Pro Asp Xaa His Gly Phe Glu His Xaa Phe 
            500                 505                 510         


Glu Val Tyr Xaa Glu Gly Glu Arg Leu Tyr Leu Phe Gly Leu Glu Ser 
        515                 520                 525             


Ala Glu Gln Ala His Glu Trp Val Lys Cys Ile Ala Lys Ala Phe Val 
    530                 535                 540                 


Pro Pro Leu Ala Glu Asp Leu Leu Ala Arg Asp Phe Glu Arg Leu Gly 
545                 550                 555                 560 


Arg Leu Pro Tyr Lys Ala Gly Leu Ser Leu Gln Arg Ala Gln Glu Gly 
                565                 570                 575     


Trp Phe Ser Leu Ser Gly Ser Glu Leu Arg Ala Val Phe Pro Glu Gly 
            580                 585                 590         


Pro Cys Glu Glu Pro Leu Gln Leu Arg Lys Leu Gln Glu Leu Ser Ile 
        595                 600                 605             


Gln Gly Asp Ser Glu Asn Gln Val Leu Val Leu Val Glu Arg Arg Arg 
    610                 615                 620                 


Xaa Leu Tyr Ile Gln Gly Glu Arg Arg Leu Asp Phe Met Gly Trp Leu 
625                 630                 635                 640 


Gly Ala Ile Gln Lys Ala Ala Ala Ser Met Gly Asp Xaa Leu Ser Glu 
                645                 650                 655     


Gln Gln Leu Gly Asp Ser Asp Ile Pro Val Ile Val Tyr Arg Cys Val 
            660                 665                 670         


Asp Tyr Ile Xaa Gln Cys Gly Leu Xaa Ser Glu Gly Ile Tyr Arg Lys 
        675                 680                 685             


Cys Gly Gln Xaa Ser Lys Xaa Gln Arg Leu Leu Glu Ser Leu Arg Gln 
    690                 695                 700                 


Asp Ala Arg Ser Val His Leu Lys Glu Gly Glu Gln His Val Asp Asp 
705                 710                 715                 720 


Val Ser Ser Ala Leu Lys Arg Phe Leu Arg Asp Leu Pro Asp Gly Leu 
                725                 730                 735     


Phe Xaa Arg Ala Gln Arg Leu Xaa Trp Leu Glu Ala Ser Glu Ile Glu 
            740                 745                 750         


Asp Glu Glu Glu Lys Val Ser Arg Tyr Arg Glu Leu Leu Val Arg Leu 
        755                 760                 765             


Pro Pro Val Asn Arg Ala Xaa Val Lys Ala Leu Ile Ser His Leu Tyr 
    770                 775                 780                 


Cys Val Gln Cys Phe Ser Asp Xaa Asn Gln Met Asn Val His Asn Leu 
785                 790                 795                 800 


Ala Ile Val Phe Gly Pro Xaa Leu Phe Gln Xaa Asp Gly Gln Asp Tyr 
                805                 810                 815     


Lys Ala Gly Arg Val Val Glu Asp Leu Ile Asn His Tyr Val Val Val 
            820                 825                 830         


Phe Ser Val Asp Glu Glu Glu Leu Arg Lys Gln Arg Glu Glu Ile Xaa 
        835                 840                 845             


Ala Ile Val Lys Met Arg Val Ala Gly Xaa Ala Ser Gly Xaa Gln His 
    850                 855                 860                 


Ala Gly Asp Phe Ile Cys Xaa Val Tyr Leu Glu Glu Lys Lys Ala Glu 
865                 870                 875                 880 


Xaa Glu Gln His Ile Lys Val Pro Ala Ser Met Xaa Ala Glu Glu Leu 
                885                 890                 895     


Xaa Leu Glu Ile Leu Asp Arg Arg Asn Val Gly Ile Arg Glu Lys Asp 
            900                 905                 910         


Tyr Trp Xaa Cys Phe Glu Val Asn Glu Arg Glu Glu Ala Glu Arg Pro 
        915                 920                 925             


Leu His Phe Ala Glu Lys Val Leu Pro Ile Leu His Gly Leu Gly Xaa 
    930                 935                 940                 


Asp Ser His Leu Val Val Lys Lys His Gln Ala Met Glu Ala Met Leu 
945                 950                 955                 960 


Leu Tyr Leu Ala Ser Arg Val Gly Asp Xaa Lys His Gly Met Met Lys 
                965                 970                 975     


Phe Arg Glu Asp Arg Ser Leu Leu Gly Leu Gly Leu Pro Ser Gly Gly 
            980                 985                 990         


Phe His Asp Arg Tyr Phe Ile Leu  Asn Ser Ser Cys Leu  Arg Leu Tyr 
        995                 1000                 1005             


Lys Glu  Val Arg Ser His Arg  Pro Glu Lys Glu Trp  Pro Ile Lys 
    1010                 1015                 1020             


Ser Leu  Lys Val Tyr Leu Gly  Val Lys Lys Lys Leu  Arg Pro Pro 
    1025                 1030                 1035             


Xaa Cys  Trp Gly Phe Xaa Val  Val His Glu Xaa Glu  Lys His Glu 
    1040                 1045                 1050             


Lys Gln  Gln Trp Tyr Leu Cys  Cys Asp Xaa Gln Met  Glu Leu Arg 
    1055                 1060                 1065             


Glu Trp  Phe Ala Xaa Phe Leu  Phe Val Gln His Asp  Gly Leu Val 
    1070                 1075                 1080             


Trp Pro  Ser Glu Pro Ser Arg  Val Ser Arg Ala Val  Pro Glu Val 
    1085                 1090                 1095             


Arg Leu  Gly Ser Val Ser Leu  Ile Pro Leu Arg Gly  Ser Glu Asn 
    1100                 1105                 1110             


Glu Met  Arg Arg Ser Val Ala  Ala Phe Xaa Ala Asp  Pro Leu Ser 
    1115                 1120                 1125             


Leu Leu  Arg Asn Val 
    1130             


<210> 2659
<211> 1194
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1105)..(1105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1184)..(1184)
<223> Selenocysteine

<400> 2659
Met Xaa Lys Lys Glu Glu Pro Pro Pro Ser Arg Val Pro Arg Ala Val 
1               5                   10                  15      


Arg Val Ala Ser Leu Leu Ser Glu Gly Glu Glu Leu Ser Gly Asp Asp 
            20                  25                  30          


Gln Gly Asp Glu Glu Glu Asp Asp His Ala Tyr Glu Gly Val Pro Asn 
        35                  40                  45              


Gly Gly Trp His Xaa Ser Ser Leu Ser Leu Ser Leu Pro Ser Xaa Ile 
    50                  55                  60                  


Ala Ala Pro His Pro Met Asp Gly Pro Pro Gly Gly Ser Xaa Pro Val 
65                  70                  75                  80  


Xaa Pro Val Ile Lys Ala Gly Trp Leu Asp Lys Asn Pro Pro Gln Gly 
                85                  90                  95      


Ser Tyr Ile Tyr Gln Lys Arg Trp Val Arg Leu Asp Xaa Asp His Leu 
            100                 105                 110         


Arg Tyr Phe Asp Ser Asn Lys Asp Ala Tyr Ser Lys Arg Phe Ile Ser 
        115                 120                 125             


Val Ala Cys Ile Ser His Val Ala Ala Ile Gly Asp Gln Lys Phe Glu 
    130                 135                 140                 


Val Ile Xaa Asn Asn Arg Xaa Phe Ala Phe Arg Ala Glu Ser Asp Val 
145                 150                 155                 160 


Glu Arg Lys Glu Trp Met Gln Ala Leu Gln Gln Ala Met Ala Glu Gln 
                165                 170                 175     


Arg Ala Arg Ala Arg Leu Ser Ser Ala Tyr Leu Leu Gly Val Pro Gly 
            180                 185                 190         


Ser Glu Gln Pro Asp Arg Ala Gly Ser Leu Glu Leu Arg Gly Phe Lys 
        195                 200                 205             


Asn Lys Leu Tyr Val Ala Val Val Gly Asp Lys Val Gln Leu Tyr Lys 
    210                 215                 220                 


Asn Leu Glu Glu Tyr His Leu Gly Ile Gly Ile Xaa Phe Ile Asp Met 
225                 230                 235                 240 


Ser Val Gly Asn Val Lys Glu Val Asp Arg Arg Ser Phe Asp Leu Xaa 
                245                 250                 255     


Xaa Pro Tyr Arg Ile Phe Ser Phe Ser Ala Asp Ser Glu Leu Glu Lys 
            260                 265                 270         


Glu Gln Trp Leu Glu Ala Met Gln Gly Ala Ile Ala Glu Ala Leu Ser 
        275                 280                 285             


Xaa Ser Glu Val Ala Glu Arg Ile Trp Ala Ala Ala Pro Asn Arg Phe 
    290                 295                 300                 


Cys Ala Asp Cys Gly Ala Pro Gln Pro Asp Trp Ala Ser Ile Asn Leu 
305                 310                 315                 320 


Cys Val Val Ile Cys Lys Arg Cys Ala Gly Glu His Arg Gly Leu Gly 
                325                 330                 335     


Ala Gly Val Ser Lys Val Arg Ser Leu Lys Met Asp Arg Lys Val Trp 
            340                 345                 350         


Xaa Glu Xaa Leu Ile Glu Leu Phe Leu Gln Leu Gly Asn Gly Ala Gly 
        355                 360                 365             


Asn Arg Phe Trp Ala Ala Asn Val Pro Pro Ser Glu Ala Leu Gln Pro 
    370                 375                 380                 


Ser Ser Ser Pro Ser Xaa Arg Arg Cys His Leu Glu Ala Lys Tyr Arg 
385                 390                 395                 400 


Glu Gly Lys Tyr Arg Arg Tyr His Pro Leu Phe Gly Asn Gln Glu Glu 
                405                 410                 415     


Leu Asp Lys Ala Leu Cys Ala Ala Val Xaa Xaa Xaa Asp Leu Ala Glu 
            420                 425                 430         


Xaa Gln Ala Leu Leu Gly Cys Gly Ala Gly Ile Asn Cys Phe Ser Gly 
        435                 440                 445             


Asp Pro Glu Ala Pro Xaa Pro Leu Ala Leu Ala Glu Gln Ala Gly Gln 
    450                 455                 460                 


Xaa Leu Gln Met Glu Phe Leu Arg Asn Asn Arg Xaa Xaa Glu Val Pro 
465                 470                 475                 480 


Arg Leu Asp Ser Met Lys Pro Leu Glu Lys His Tyr Ser Val Val Leu 
                485                 490                 495     


Pro Xaa Val Ser His Ser Gly Phe Leu Tyr Lys Xaa Ala Ser Ala Gly 
            500                 505                 510         


Lys Leu Leu Gln Asp Arg Arg Ala Arg Glu Glu Phe Ser Arg Arg Trp 
        515                 520                 525             


Cys Val Leu Gly Asp Gly Val Leu Ser Tyr Phe Glu Asn Glu Arg Ala 
    530                 535                 540                 


Val Xaa Pro Asn Gly Glu Ile Arg Ala Ser Glu Ile Val Cys Leu Ala 
545                 550                 555                 560 


Val Pro Pro Pro Asp Xaa His Gly Phe Glu His Xaa Phe Glu Val Tyr 
                565                 570                 575     


Xaa Glu Gly Glu Arg Leu Tyr Leu Phe Gly Leu Glu Ser Ala Glu Gln 
            580                 585                 590         


Ala His Glu Trp Val Lys Cys Ile Ala Lys Ala Phe Val Pro Pro Leu 
        595                 600                 605             


Ala Glu Asp Leu Leu Ala Arg Asp Phe Glu Arg Leu Gly Arg Leu Pro 
    610                 615                 620                 


Tyr Lys Ala Gly Leu Ser Leu Gln Arg Ala Gln Glu Gly Trp Phe Ser 
625                 630                 635                 640 


Leu Ser Gly Ser Glu Leu Arg Ala Val Phe Pro Glu Gly Pro Cys Glu 
                645                 650                 655     


Glu Pro Leu Gln Leu Arg Lys Leu Gln Glu Leu Ser Ile Gln Gly Asp 
            660                 665                 670         


Ser Glu Asn Gln Val Leu Val Leu Val Glu Arg Arg Arg Xaa Leu Tyr 
        675                 680                 685             


Ile Gln Gly Glu Arg Arg Leu Asp Phe Met Gly Trp Leu Gly Ala Ile 
    690                 695                 700                 


Gln Lys Ala Ala Ala Ser Met Gly Asp Xaa Leu Ser Glu Gln Gln Leu 
705                 710                 715                 720 


Gly Asp Ser Asp Ile Pro Val Ile Val Tyr Arg Cys Val Asp Tyr Ile 
                725                 730                 735     


Xaa Gln Cys Gly Leu Xaa Ser Glu Gly Ile Tyr Arg Lys Cys Gly Gln 
            740                 745                 750         


Xaa Ser Lys Xaa Gln Arg Leu Leu Glu Ser Leu Arg Gln Asp Ala Arg 
        755                 760                 765             


Ser Val His Leu Lys Glu Gly Glu Gln His Val Asp Asp Val Ser Ser 
    770                 775                 780                 


Ala Leu Lys Arg Phe Leu Arg Asp Leu Pro Asp Gly Leu Phe Xaa Arg 
785                 790                 795                 800 


Ala Gln Arg Leu Xaa Trp Leu Glu Ala Ser Glu Ile Glu Asp Glu Glu 
                805                 810                 815     


Glu Lys Val Ser Arg Tyr Arg Glu Leu Leu Val Arg Leu Pro Pro Val 
            820                 825                 830         


Asn Arg Ala Xaa Val Lys Ala Leu Ile Ser His Leu Tyr Cys Val Gln 
        835                 840                 845             


Cys Phe Ser Asp Xaa Asn Gln Met Asn Val His Asn Leu Ala Ile Val 
    850                 855                 860                 


Phe Gly Pro Xaa Leu Phe Gln Xaa Asp Gly Gln Asp Tyr Lys Ala Gly 
865                 870                 875                 880 


Arg Val Val Glu Asp Leu Ile Asn His Tyr Val Val Val Phe Ser Val 
                885                 890                 895     


Asp Glu Glu Glu Leu Arg Lys Gln Arg Glu Glu Ile Xaa Ala Ile Val 
            900                 905                 910         


Lys Met Arg Val Ala Gly Xaa Ala Ser Gly Xaa Gln His Ala Gly Asp 
        915                 920                 925             


Phe Ile Cys Xaa Val Tyr Leu Glu Glu Lys Lys Ala Glu Xaa Glu Gln 
    930                 935                 940                 


His Ile Lys Val Pro Ala Ser Met Xaa Ala Glu Glu Leu Xaa Leu Glu 
945                 950                 955                 960 


Ile Leu Asp Arg Arg Asn Val Gly Ile Arg Glu Lys Asp Tyr Trp Xaa 
                965                 970                 975     


Cys Phe Glu Val Asn Glu Arg Glu Glu Ala Glu Arg Pro Leu His Phe 
            980                 985                 990         


Ala Glu Lys Val Leu Pro Ile Leu  His Gly Leu Gly Xaa  Asp Ser His 
        995                 1000                 1005             


Leu Val  Val Lys Lys His Gln  Ala Met Glu Ala Met  Leu Leu Tyr 
    1010                 1015                 1020             


Leu Ala  Ser Arg Val Gly Asp  Xaa Lys His Gly Met  Met Lys Phe 
    1025                 1030                 1035             


Arg Glu  Asp Arg Ser Leu Leu  Gly Leu Gly Leu Pro  Ser Gly Gly 
    1040                 1045                 1050             


Phe His  Asp Arg Tyr Phe Ile  Leu Asn Ser Ser Cys  Leu Arg Leu 
    1055                 1060                 1065             


Tyr Lys  Glu Val Arg Ser His  Arg Pro Glu Lys Glu  Trp Pro Ile 
    1070                 1075                 1080             


Lys Ser  Leu Lys Val Tyr Leu  Gly Val Lys Lys Lys  Leu Arg Pro 
    1085                 1090                 1095             


Pro Xaa  Cys Trp Gly Phe Xaa  Val Val His Glu Xaa  Glu Lys His 
    1100                 1105                 1110             


Glu Lys  Gln Gln Trp Tyr Leu  Cys Cys Asp Xaa Gln  Met Glu Leu 
    1115                 1120                 1125             


Arg Glu  Trp Phe Ala Xaa Phe  Leu Phe Val Gln His  Asp Gly Leu 
    1130                 1135                 1140             


Val Trp  Pro Ser Glu Pro Ser  Arg Val Ser Arg Ala  Val Pro Glu 
    1145                 1150                 1155             


Val Arg  Leu Gly Ser Val Ser  Leu Ile Pro Leu Arg  Gly Ser Glu 
    1160                 1165                 1170             


Asn Glu  Met Arg Arg Ser Val  Ala Ala Phe Xaa Ala  Asp Pro Leu 
    1175                 1180                 1185             


Ser Leu  Leu Arg Asn Val 
    1190                 


<210> 2660
<211> 1205
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1145)..(1145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1195)..(1195)
<223> Selenocysteine

<400> 2660
Met Xaa Lys Lys Glu Glu Pro Pro Pro Ser Arg Val Pro Arg Ala Val 
1               5                   10                  15      


Arg Val Ala Ser Leu Leu Ser Glu Gly Glu Glu Leu Ser Gly Asp Asp 
            20                  25                  30          


Gln Gly Asp Glu Glu Glu Asp Asp His Ala Tyr Glu Gly Val Pro Asn 
        35                  40                  45              


Gly Gly Trp His Xaa Ser Ser Leu Ser Leu Ser Leu Pro Ser Xaa Ile 
    50                  55                  60                  


Ala Ala Pro His Pro Met Asp Gly Pro Pro Gly Gly Ser Xaa Pro Val 
65                  70                  75                  80  


Xaa Pro Val Ile Lys Ala Gly Trp Leu Asp Lys Asn Pro Pro Gln Gly 
                85                  90                  95      


Ser Tyr Ile Tyr Gln Lys Arg Trp Val Arg Leu Asp Xaa Asp His Leu 
            100                 105                 110         


Arg Tyr Phe Asp Ser Asn Lys Asp Ala Tyr Ser Lys Arg Phe Ile Ser 
        115                 120                 125             


Val Ala Cys Ile Ser His Val Ala Ala Ile Gly Asp Gln Lys Phe Glu 
    130                 135                 140                 


Val Ile Xaa Asn Asn Arg Xaa Phe Ala Phe Arg Ala Glu Ser Asp Val 
145                 150                 155                 160 


Glu Arg Lys Glu Trp Met Gln Ala Leu Gln Gln Ala Met Ala Glu Gln 
                165                 170                 175     


Arg Ala Arg Ala Arg Leu Ser Ser Ala Tyr Leu Leu Gly Val Pro Gly 
            180                 185                 190         


Ser Glu Gln Pro Asp Arg Ala Gly Ser Leu Glu Leu Arg Gly Phe Lys 
        195                 200                 205             


Asn Lys Leu Tyr Val Ala Val Val Gly Asp Lys Val Gln Leu Tyr Lys 
    210                 215                 220                 


Asn Leu Glu Glu Tyr His Leu Gly Ile Gly Ile Xaa Phe Ile Asp Met 
225                 230                 235                 240 


Ser Val Gly Asn Val Lys Glu Val Asp Arg Arg Ser Phe Asp Leu Xaa 
                245                 250                 255     


Xaa Pro Tyr Arg Ile Phe Ser Phe Ser Ala Asp Ser Glu Leu Glu Lys 
            260                 265                 270         


Glu Gln Trp Leu Glu Ala Met Gln Gly Ala Ile Ala Glu Ala Leu Ser 
        275                 280                 285             


Xaa Ser Glu Val Ala Glu Arg Ile Trp Ala Ala Ala Pro Asn Arg Phe 
    290                 295                 300                 


Cys Ala Asp Cys Gly Ala Pro Gln Pro Asp Trp Ala Ser Ile Asn Leu 
305                 310                 315                 320 


Cys Val Val Ile Cys Lys Arg Cys Ala Gly Glu His Arg Gly Leu Gly 
                325                 330                 335     


Ala Gly Val Ser Lys Val Arg Ser Leu Lys Met Asp Arg Lys Val Trp 
            340                 345                 350         


Xaa Glu Xaa Leu Ile Glu Leu Phe Leu Gln Leu Gly Asn Gly Ala Gly 
        355                 360                 365             


Asn Arg Phe Trp Ala Ala Asn Val Pro Pro Ser Glu Ala Leu Gln Pro 
    370                 375                 380                 


Ser Ser Ser Pro Ser Xaa Arg Arg Cys His Leu Glu Ala Lys Tyr Arg 
385                 390                 395                 400 


Glu Gly Lys Tyr Arg Arg Tyr His Pro Leu Phe Gly Asn Gln Glu Glu 
                405                 410                 415     


Leu Asp Lys Ala Leu Cys Ala Ala Val Xaa Xaa Xaa Asp Leu Ala Glu 
            420                 425                 430         


Xaa Gln Ala Leu Leu Gly Cys Gly Ala Gly Ile Asn Cys Phe Ser Gly 
        435                 440                 445             


Asp Pro Glu Ala Pro Xaa Pro Leu Ala Leu Ala Glu Gln Ala Gly Gln 
    450                 455                 460                 


Xaa Leu Gln Met Glu Phe Leu Arg Asn Asn Arg Xaa Xaa Glu Val Pro 
465                 470                 475                 480 


Arg Leu Asp Ser Met Lys Pro Leu Glu Lys His Tyr Ser Val Val Leu 
                485                 490                 495     


Pro Xaa Val Ser His Ser Gly Phe Leu Tyr Lys Xaa Ala Ser Ala Gly 
            500                 505                 510         


Lys Leu Leu Gln Asp Arg Arg Ala Arg Glu Glu Phe Ser Arg Arg Trp 
        515                 520                 525             


Cys Val Leu Gly Asp Gly Val Leu Ser Tyr Phe Glu Asn Glu Arg Ala 
    530                 535                 540                 


Val Xaa Pro Asn Gly Glu Ile Arg Ala Ser Glu Ile Val Cys Leu Ala 
545                 550                 555                 560 


Val Pro Pro Pro Asp Xaa His Gly Phe Glu His Xaa Phe Glu Val Tyr 
                565                 570                 575     


Xaa Glu Gly Glu Arg Leu Tyr Leu Phe Gly Leu Glu Ser Ala Glu Gln 
            580                 585                 590         


Ala His Glu Trp Val Lys Cys Ile Ala Lys Ala Phe Val Pro Pro Leu 
        595                 600                 605             


Ala Glu Asp Leu Leu Ala Arg Asp Phe Glu Arg Leu Gly Arg Leu Pro 
    610                 615                 620                 


Tyr Lys Ala Gly Leu Ser Leu Gln Arg Ala Gln Glu Gly Trp Phe Ser 
625                 630                 635                 640 


Leu Ser Gly Ser Glu Leu Arg Ala Val Phe Pro Glu Gly Pro Cys Glu 
                645                 650                 655     


Glu Pro Leu Gln Leu Arg Lys Leu Gln Glu Leu Ser Ile Gln Gly Asp 
            660                 665                 670         


Ser Glu Asn Gln Val Leu Val Leu Val Glu Arg Arg Arg Xaa Leu Tyr 
        675                 680                 685             


Ile Gln Gly Glu Arg Arg Leu Asp Phe Met Gly Trp Leu Gly Ala Ile 
    690                 695                 700                 


Gln Lys Ala Ala Ala Ser Met Gly Asp Xaa Leu Ser Glu Gln Gln Leu 
705                 710                 715                 720 


Gly Asp Ser Asp Ile Pro Val Ile Val Tyr Arg Cys Val Asp Tyr Ile 
                725                 730                 735     


Xaa Gln Cys Gly Leu Xaa Ser Glu Gly Ile Tyr Arg Lys Cys Gly Gln 
            740                 745                 750         


Xaa Ser Lys Xaa Gln Arg Leu Leu Glu Ser Leu Arg Gln Asp Ala Arg 
        755                 760                 765             


Ser Val His Leu Lys Glu Gly Glu Gln His Val Asp Asp Val Ser Ser 
    770                 775                 780                 


Ala Leu Lys Arg Phe Leu Arg Asp Leu Pro Asp Gly Leu Phe Xaa Arg 
785                 790                 795                 800 


Ala Gln Arg Leu Xaa Trp Leu Glu Ala Ser Glu Ile Glu Asp Glu Glu 
                805                 810                 815     


Glu Lys Val Ser Arg Tyr Arg Glu Leu Leu Val Arg Leu Pro Pro Val 
            820                 825                 830         


Asn Arg Ala Xaa Val Lys Ala Leu Ile Ser His Leu Tyr Cys Val Gln 
        835                 840                 845             


Cys Phe Ser Asp Xaa Asn Gln Met Asn Val His Asn Leu Ala Ile Val 
    850                 855                 860                 


Phe Gly Pro Xaa Leu Phe Gln Xaa Asp Gly Gln Asp Tyr Lys Ala Gly 
865                 870                 875                 880 


Arg Val Val Glu Asp Leu Ile Asn His Tyr Val Val Val Phe Ser Val 
                885                 890                 895     


Asp Glu Glu Glu Leu Arg Lys Gln Arg Glu Glu Ile Xaa Ala Ile Val 
            900                 905                 910         


Lys Met Arg Val Ala Gly Xaa Ala Ser Gly Xaa Gln His Ala Gly Asp 
        915                 920                 925             


Phe Ile Cys Xaa Val Tyr Leu Glu Glu Lys Lys Ala Glu Xaa Glu Gln 
    930                 935                 940                 


His Ile Lys Val Pro Ala Ser Met Xaa Ala Glu Glu Leu Xaa Leu Glu 
945                 950                 955                 960 


Ile Leu Asp Arg Arg Asn Val Gly Ile Arg Glu Lys Asp Tyr Trp Xaa 
                965                 970                 975     


Cys Phe Glu Val Asn Glu Arg Glu Glu Ala Glu Arg Pro Leu His Phe 
            980                 985                 990         


Ala Glu Lys Val Leu Pro Ile Leu  His Gly Leu Gly Xaa  Asp Ser His 
        995                 1000                 1005             


Leu Val  Val Lys Lys His Gln  Ala Met Glu Ala Met  Leu Leu Tyr 
    1010                 1015                 1020             


Leu Ala  Ser Arg Val Gly Asp  Xaa Lys His Gly Met  Met Lys Phe 
    1025                 1030                 1035             


Arg Glu  Asp Arg Ser Leu Leu  Gly Leu Gly Leu Pro  Ser Gly Gly 
    1040                 1045                 1050             


Phe His  Asp Arg Tyr Phe Ile  Leu Asn Ser Ser Cys  Leu Arg Leu 
    1055                 1060                 1065             


Tyr Lys  Glu Val Arg Ser Gln  Arg Pro Trp Ser Gly  Ala Pro Glu 
    1070                 1075                 1080             


Xaa Ser  His Arg Pro Glu Lys  Glu Trp Pro Ile Lys  Ser Leu Lys 
    1085                 1090                 1095             


Val Tyr  Leu Gly Val Lys Lys  Lys Leu Arg Pro Pro  Xaa Cys Trp 
    1100                 1105                 1110             


Gly Phe  Xaa Val Val His Glu  Xaa Glu Lys His Glu  Lys Gln Gln 
    1115                 1120                 1125             


Trp Tyr  Leu Cys Cys Asp Xaa  Gln Met Glu Leu Arg  Glu Trp Phe 
    1130                 1135                 1140             


Ala Xaa  Phe Leu Phe Val Gln  His Asp Gly Leu Val  Trp Pro Ser 
    1145                 1150                 1155             


Glu Pro  Ser Arg Val Ser Arg  Ala Val Pro Glu Val  Arg Leu Gly 
    1160                 1165                 1170             


Ser Val  Ser Leu Ile Pro Leu  Arg Gly Ser Glu Asn  Glu Met Arg 
    1175                 1180                 1185             


Arg Ser  Val Ala Ala Phe Xaa  Ala Asp Pro Leu Ser  Leu Leu Arg 
    1190                 1195                 1200             


Asn Val  
    1205 


<210> 2661
<211> 1210
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (873)..(873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1200)..(1200)
<223> Selenocysteine

<400> 2661
Met Xaa Leu Ser Gly Ser Arg Gly Gln Glu Glu Pro Pro Pro Ser Arg 
1               5                   10                  15      


Val Pro Arg Ala Val Arg Val Ala Ser Leu Leu Ser Glu Gly Glu Glu 
            20                  25                  30          


Leu Ser Gly Asp Asp Gln Gly Asp Glu Glu Glu Asp Asp His Ala Tyr 
        35                  40                  45              


Glu Gly Val Pro Asn Gly Gly Trp His Xaa Ser Ser Leu Ser Leu Ser 
    50                  55                  60                  


Leu Pro Ser Xaa Ile Ala Ala Pro His Pro Met Asp Gly Pro Pro Gly 
65                  70                  75                  80  


Gly Ser Xaa Pro Val Xaa Pro Val Ile Lys Ala Gly Trp Leu Asp Lys 
                85                  90                  95      


Asn Pro Pro Gln Gly Ser Tyr Ile Tyr Gln Lys Arg Trp Val Arg Leu 
            100                 105                 110         


Asp Xaa Asp His Leu Arg Tyr Phe Asp Ser Asn Lys Asp Ala Tyr Ser 
        115                 120                 125             


Lys Arg Phe Ile Ser Val Ala Cys Ile Ser His Val Ala Ala Ile Gly 
    130                 135                 140                 


Asp Gln Lys Phe Glu Val Ile Xaa Asn Asn Arg Xaa Phe Ala Phe Arg 
145                 150                 155                 160 


Ala Glu Ser Asp Val Glu Arg Lys Glu Trp Met Gln Ala Leu Gln Gln 
                165                 170                 175     


Ala Met Ala Glu Gln Arg Ala Arg Ala Arg Leu Ser Ser Ala Tyr Leu 
            180                 185                 190         


Leu Gly Val Pro Gly Ser Glu Gln Pro Asp Arg Ala Gly Ser Leu Glu 
        195                 200                 205             


Leu Arg Gly Phe Lys Asn Lys Leu Tyr Val Ala Val Val Gly Asp Lys 
    210                 215                 220                 


Val Gln Leu Tyr Lys Asn Leu Glu Glu Tyr His Leu Gly Ile Gly Ile 
225                 230                 235                 240 


Xaa Phe Ile Asp Met Ser Val Gly Asn Val Lys Glu Val Asp Arg Arg 
                245                 250                 255     


Ser Phe Asp Leu Xaa Xaa Pro Tyr Arg Ile Phe Ser Phe Ser Ala Asp 
            260                 265                 270         


Ser Glu Leu Glu Lys Glu Gln Trp Leu Glu Ala Met Gln Gly Ala Ile 
        275                 280                 285             


Ala Glu Ala Leu Ser Xaa Ser Glu Val Ala Glu Arg Ile Trp Ala Ala 
    290                 295                 300                 


Ala Pro Asn Arg Phe Cys Ala Asp Cys Gly Ala Pro Gln Pro Asp Trp 
305                 310                 315                 320 


Ala Ser Ile Asn Leu Cys Val Val Ile Cys Lys Arg Cys Ala Gly Glu 
                325                 330                 335     


His Arg Gly Leu Gly Ala Gly Val Ser Lys Val Arg Ser Leu Lys Met 
            340                 345                 350         


Asp Arg Lys Val Trp Xaa Glu Xaa Leu Ile Glu Leu Phe Leu Gln Leu 
        355                 360                 365             


Gly Asn Gly Ala Gly Asn Arg Phe Trp Ala Ala Asn Val Pro Pro Ser 
    370                 375                 380                 


Glu Ala Leu Gln Pro Ser Ser Ser Pro Ser Xaa Arg Arg Cys His Leu 
385                 390                 395                 400 


Glu Ala Lys Tyr Arg Glu Gly Lys Tyr Arg Arg Tyr His Pro Leu Phe 
                405                 410                 415     


Gly Asn Gln Glu Glu Leu Asp Lys Ala Leu Cys Ala Ala Val Xaa Xaa 
            420                 425                 430         


Xaa Asp Leu Ala Glu Xaa Gln Ala Leu Leu Gly Cys Gly Ala Gly Ile 
        435                 440                 445             


Asn Cys Phe Ser Gly Asp Pro Glu Ala Pro Xaa Pro Leu Ala Leu Ala 
    450                 455                 460                 


Glu Gln Ala Gly Gln Xaa Leu Gln Met Glu Phe Leu Arg Asn Asn Arg 
465                 470                 475                 480 


Xaa Xaa Glu Val Pro Arg Leu Asp Ser Met Lys Pro Leu Glu Lys His 
                485                 490                 495     


Tyr Ser Val Val Leu Pro Xaa Val Ser His Ser Gly Phe Leu Tyr Lys 
            500                 505                 510         


Xaa Ala Ser Ala Gly Lys Leu Leu Gln Asp Arg Arg Ala Arg Glu Glu 
        515                 520                 525             


Phe Ser Arg Arg Trp Cys Val Leu Gly Asp Gly Val Leu Ser Tyr Phe 
    530                 535                 540                 


Glu Asn Glu Arg Ala Val Xaa Pro Asn Gly Glu Ile Arg Ala Ser Glu 
545                 550                 555                 560 


Ile Val Cys Leu Ala Val Pro Pro Pro Asp Xaa His Gly Phe Glu His 
                565                 570                 575     


Xaa Phe Glu Val Tyr Xaa Glu Gly Glu Arg Leu Tyr Leu Phe Gly Leu 
            580                 585                 590         


Glu Ser Ala Glu Gln Ala His Glu Trp Val Lys Cys Ile Ala Lys Ala 
        595                 600                 605             


Phe Val Pro Pro Leu Ala Glu Asp Leu Leu Ala Arg Asp Phe Glu Arg 
    610                 615                 620                 


Leu Gly Arg Leu Pro Tyr Lys Ala Gly Leu Ser Leu Gln Arg Ala Gln 
625                 630                 635                 640 


Glu Gly Trp Phe Ser Leu Ser Gly Ser Glu Leu Arg Ala Val Phe Pro 
                645                 650                 655     


Glu Gly Pro Cys Glu Glu Pro Leu Gln Leu Arg Lys Leu Gln Glu Leu 
            660                 665                 670         


Ser Ile Gln Gly Asp Ser Glu Asn Gln Val Leu Val Leu Val Glu Arg 
        675                 680                 685             


Arg Arg Xaa Leu Tyr Ile Gln Gly Glu Arg Arg Leu Asp Phe Met Gly 
    690                 695                 700                 


Trp Leu Gly Ala Ile Gln Lys Ala Ala Ala Ser Met Gly Asp Xaa Leu 
705                 710                 715                 720 


Ser Glu Gln Gln Leu Gly Asp Ser Asp Ile Pro Val Ile Val Tyr Arg 
                725                 730                 735     


Cys Val Asp Tyr Ile Xaa Gln Cys Gly Leu Xaa Ser Glu Gly Ile Tyr 
            740                 745                 750         


Arg Lys Cys Gly Gln Xaa Ser Lys Xaa Gln Arg Leu Leu Glu Ser Leu 
        755                 760                 765             


Arg Gln Asp Ala Arg Ser Val His Leu Lys Glu Gly Glu Gln His Val 
    770                 775                 780                 


Asp Asp Val Ser Ser Ala Leu Lys Arg Phe Leu Arg Asp Leu Pro Asp 
785                 790                 795                 800 


Gly Leu Phe Xaa Arg Ala Gln Arg Leu Xaa Trp Leu Glu Ala Ser Glu 
                805                 810                 815     


Ile Glu Asp Glu Glu Glu Lys Val Ser Arg Tyr Arg Glu Leu Leu Val 
            820                 825                 830         


Arg Leu Pro Pro Val Asn Arg Ala Xaa Val Lys Ala Leu Ile Ser His 
        835                 840                 845             


Leu Tyr Cys Val Gln Cys Phe Ser Asp Xaa Asn Gln Met Asn Val His 
    850                 855                 860                 


Asn Leu Ala Ile Val Phe Gly Pro Xaa Leu Phe Gln Xaa Asp Gly Gln 
865                 870                 875                 880 


Asp Tyr Lys Ala Gly Arg Val Val Glu Asp Leu Ile Asn His Tyr Val 
                885                 890                 895     


Val Val Phe Ser Val Asp Glu Glu Glu Leu Arg Lys Gln Arg Glu Glu 
            900                 905                 910         


Ile Xaa Ala Ile Val Lys Met Arg Val Ala Gly Xaa Ala Ser Gly Xaa 
        915                 920                 925             


Gln His Ala Gly Asp Phe Ile Cys Xaa Val Tyr Leu Glu Glu Lys Lys 
    930                 935                 940                 


Ala Glu Xaa Glu Gln His Ile Lys Val Pro Ala Ser Met Xaa Ala Glu 
945                 950                 955                 960 


Glu Leu Xaa Leu Glu Ile Leu Asp Arg Arg Asn Val Gly Ile Arg Glu 
                965                 970                 975     


Lys Asp Tyr Trp Xaa Cys Phe Glu Val Asn Glu Arg Glu Glu Ala Glu 
            980                 985                 990         


Arg Pro Leu His Phe Ala Glu Lys  Val Leu Pro Ile Leu  His Gly Leu 
        995                 1000                 1005             


Gly Xaa  Asp Ser His Leu Val  Val Lys Lys His Gln  Ala Met Glu 
    1010                 1015                 1020             


Ala Met  Leu Leu Tyr Leu Ala  Ser Arg Val Gly Asp  Xaa Lys His 
    1025                 1030                 1035             


Gly Met  Met Lys Phe Arg Glu  Asp Arg Ser Leu Leu  Gly Leu Gly 
    1040                 1045                 1050             


Leu Pro  Ser Gly Gly Phe His  Asp Arg Tyr Phe Ile  Leu Asn Ser 
    1055                 1060                 1065             


Ser Cys  Leu Arg Leu Tyr Lys  Glu Val Arg Ser Gln  Arg Pro Trp 
    1070                 1075                 1080             


Ser Gly  Ala Pro Glu Xaa Ser  His Arg Pro Glu Lys  Glu Trp Pro 
    1085                 1090                 1095             


Ile Lys  Ser Leu Lys Val Tyr  Leu Gly Val Lys Lys  Lys Leu Arg 
    1100                 1105                 1110             


Pro Pro  Xaa Cys Trp Gly Phe  Xaa Val Val His Glu  Xaa Glu Lys 
    1115                 1120                 1125             


His Glu  Lys Gln Gln Trp Tyr  Leu Cys Cys Asp Xaa  Gln Met Glu 
    1130                 1135                 1140             


Leu Arg  Glu Trp Phe Ala Xaa  Phe Leu Phe Val Gln  His Asp Gly 
    1145                 1150                 1155             


Leu Val  Trp Pro Ser Glu Pro  Ser Arg Val Ser Arg  Ala Val Pro 
    1160                 1165                 1170             


Glu Val  Arg Leu Gly Ser Val  Ser Leu Ile Pro Leu  Arg Gly Ser 
    1175                 1180                 1185             


Glu Asn  Glu Met Arg Arg Ser  Val Ala Ala Phe Xaa  Ala Asp Pro 
    1190                 1195                 1200             


Leu Ser  Leu Leu Arg Asn Val  
    1205                 1210 


<210> 2662
<211> 178
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<400> 2662
Xaa Lys Lys Lys Leu Arg Pro Pro Xaa Cys Trp Gly Phe Xaa Val Val 
1               5                   10                  15      


His Glu Xaa Glu Lys His Glu Lys Gln Gln Trp Tyr Leu Cys Cys Asp 
            20                  25                  30          


Xaa Gln Met Glu Leu Arg Glu Trp Phe Ala Xaa Phe Leu Phe Val Gln 
        35                  40                  45              


His Asp Gly Leu Val Trp Pro Ser Glu Pro Ser Arg Val Ser Arg Ala 
    50                  55                  60                  


Val Pro Glu Val Arg Leu Gly Ser Val Ser Leu Ile Pro Leu Arg Gly 
65                  70                  75                  80  


Ser Glu Asn Glu Met Arg Arg Ser Val Ala Ala Phe Xaa Ala Asp Pro 
                85                  90                  95      


Leu Ser Val Ser Gly Ser Pro Cys Leu Trp Ala Gly Gly Trp Gly Pro 
            100                 105                 110         


Gly Trp Val Pro Ala Phe Tyr Ser Xaa Val Asp Asp Cys Pro Asp Cys 
        115                 120                 125             


Pro Pro Arg Leu Pro Ser Gly Pro Leu Pro Pro Ala Leu Val Gly Ala 
    130                 135                 140                 


Leu Ile Gly Leu Phe Gly Ser His His Ser Lys Glu Pro Leu Leu Pro 
145                 150                 155                 160 


Gly Pro Gly Ser Trp Glu Ser Pro Leu Pro Gly Pro Gly Ser Trp Glu 
                165                 170                 175     


Pro Gly 
        


<210> 2663
<211> 863
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<400> 2663
Met Asp Ala Ser Ile Trp Ser Asn Glu Leu Ile Glu Leu Phe Ile Val 
1               5                   10                  15      


Ile Gly Asn Lys Arg Ala Asn Asp Phe Trp Ala Gly Asn Leu Gln Lys 
            20                  25                  30          


Asp Glu Glu Leu His Met Asp Ser Pro Val Glu Lys Arg Lys Asn Phe 
        35                  40                  45              


Ile Xaa Gln Lys Tyr Lys Glu Gly Lys Phe Arg Lys Xaa Leu Leu Ala 
    50                  55                  60                  


Ser Leu Xaa Lys Glu Glu Leu Asn Lys Ala Leu Cys Ala Ala Val Val 
65                  70                  75                  80  


Lys Pro Asp Val Leu Glu Xaa Met Ala Leu Leu Phe Ser Gly Ala Asp 
                85                  90                  95      


Val Met Cys Ala Xaa Gly Asp Pro Val His Ser Xaa Pro Tyr Leu Leu 
            100                 105                 110         


Ala Lys Lys Ala Gly Gln Ser Leu Gln Met Glu Phe Leu Tyr His Asn 
        115                 120                 125             


Lys Phe Ser Asp Phe Pro Gln His Asp Ile His Ser Glu Gly Val Leu 
    130                 135                 140                 


Ser Gln Glu Ser Ser Gln Ser Xaa Phe Leu Cys Asp Phe Leu Tyr Gln 
145                 150                 155                 160 


Ala Pro Ser Ala Ala Ser Lys Leu Ser Ser Glu Lys Lys Leu Leu Glu 
                165                 170                 175     


Glu Xaa Asn Lys Lys Trp Cys Val Leu Glu Gly Gly Phe Leu Ser Tyr 
            180                 185                 190         


Tyr Glu Asn Asp Lys Ser Xaa Xaa Pro Asn Gly Xaa Ile Asn Ile Asn 
        195                 200                 205             


Glu Val Ile Cys Leu Ala Ile His Lys Glu Asp Phe Tyr Leu Asn Xaa 
    210                 215                 220                 


Gly Pro Ile Phe Ile Phe Glu Ile Tyr Leu Pro Ser Glu Arg Val Phe 
225                 230                 235                 240 


Leu Phe Gly Ala Glu Xaa Ser Gln Ala Gln Arg Lys Trp Xaa Glu Ala 
                245                 250                 255     


Ile Ala Lys His Phe Val Pro Leu Phe Ala Glu Asn Leu Xaa Glu Ala 
            260                 265                 270         


Asp Tyr Asp Leu Ile Gly Gln Leu Phe Tyr Lys Asp Cys His Ala Leu 
        275                 280                 285             


Asp Gln Trp Arg Lys Gly Trp Phe Ala Met Asp Lys Ser Ser Leu His 
    290                 295                 300                 


Phe Cys Leu Gln Met Gln Glu Val Gln Gly Asp Arg Met His Leu Arg 
305                 310                 315                 320 


Arg Leu Gln Glu Leu Xaa Ile Ser Xaa Met Val Gln Asn Gly Glu Lys 
                325                 330                 335     


Leu Asp Val Leu Leu Leu Val Glu Lys Gly Arg Xaa Leu Tyr Ile His 
            340                 345                 350         


Gly His Xaa Lys Leu Asp Phe Xaa Val Trp His Xaa Ala Ile Glu Lys 
        355                 360                 365             


Ala Ala Gly Xaa Asp Gly Asn Ala Leu Gln Asp Gln Gln Leu Ser Lys 
    370                 375                 380                 


Asn Asp Val Pro Ile Ile Val Asn Ser Cys Ile Ala Phe Val Xaa Gln 
385                 390                 395                 400 


Tyr Gly Leu Gly Cys Lys Tyr Ile Tyr Gln Lys Asn Gly Asp Pro Leu 
                405                 410                 415     


His Ile Ser Glu Leu Leu Glu Ser Phe Lys Lys Asp Ala Arg Ser Phe 
            420                 425                 430         


Lys Leu Arg Ala Gly Lys His Gln Leu Glu Asp Val Xaa Ala Val Leu 
        435                 440                 445             


Lys Ser Phe Leu Ser Asp Ile Asp Asp Ala Leu Leu Xaa Lys Glu Leu 
    450                 455                 460                 


Tyr Pro Tyr Trp Ile Ser Ala Leu Asp Xaa Gln Asp Asp Lys Glu Arg 
465                 470                 475                 480 


Ile Lys Lys Tyr Gly Ala Phe Ile Arg Ser Leu Pro Gly Val Asn Arg 
                485                 490                 495     


Ala Xaa Leu Ala Ala Ile Ile Glu His Leu Tyr Arg Val Gln Lys Cys 
            500                 505                 510         


Ser Glu Ile Asn His Met Asn Ala His Asn Leu Ala Leu Val Phe Ser 
        515                 520                 525             


Ser Cys Leu Phe Gln Xaa Lys Gly Gln Xaa Ser Glu Glu Val Asn Val 
    530                 535                 540                 


Ile Glu Asp Leu Ile Asn Asn Tyr Val Glu Ile Phe Glu Val Lys Glu 
545                 550                 555                 560 


Asp Gln Val Lys Gln Met Asp Ile Glu Asn Ser Phe Ile Xaa Lys Trp 
                565                 570                 575     


Lys Asp Xaa Gln Val Ser Gln Ala Gly Asp Leu Leu Ile Glu Val Tyr 
            580                 585                 590         


Val Glu Arg Lys Glu Pro Asp Cys Ser Ile Ile Ile Arg Ile Ser Pro 
        595                 600                 605             


Val Met Glu Ala Glu Glu Leu Xaa Asn Asp Ile Leu Ala Ile Lys Asn 
    610                 615                 620                 


Ile Ile Pro Xaa Lys Gly Asp Ile Trp Ala Xaa Phe Glu Val Ile Glu 
625                 630                 635                 640 


Asn Glu Glu Leu Glu Arg Pro Leu His Tyr Lys Glu Asn Val Leu Glu 
                645                 650                 655     


Gln Val Leu Arg Trp Ser Ser Leu Ala Glu Pro Gly Ser Ala Tyr Leu 
            660                 665                 670         


Val Val Lys Arg Phe Leu Xaa Ala Asp Xaa Ile Lys His Cys Ser Asp 
        675                 680                 685             


Arg Ser Xaa Leu Gly Ser Ile Lys Glu Gly Ile Leu Lys Ile Lys Glu 
    690                 695                 700                 


Glu Pro Ser Lys Ile Leu Ser Gly Asn Lys Phe Gln Asp Arg Tyr Phe 
705                 710                 715                 720 


Val Leu Arg Asp Gly Phe Leu Phe Leu Tyr Lys Asp Val Lys Ser Ser 
                725                 730                 735     


Lys His Asp Lys Met Phe Ser Leu Ser Ser Met Lys Phe Tyr Arg Gly 
            740                 745                 750         


Val Lys Lys Lys Met Lys Pro Pro Xaa Ser Trp Gly Leu Xaa Ala Tyr 
        755                 760                 765             


Ser Glu Lys His His Trp His Leu Cys Cys Asp Ser Ser Arg Xaa Gln 
    770                 775                 780                 


Xaa Glu Trp Met Xaa Ser Ile Phe Ile Ala Gln His Glu Tyr Asp Ile 
785                 790                 795                 800 


Trp Pro Pro Ala Gly Lys Glu Arg Lys Arg Ser Ile Xaa Lys Asn Pro 
                805                 810                 815     


Lys Ile Gly Gly Leu Pro Leu Ile Pro Ile Gln His Glu Gly Asn Ala 
            820                 825                 830         


Xaa Leu Ala Arg Lys Ile Leu Arg Val Gln Glu Gln Asn Leu Lys Gly 
        835                 840                 845             


Cys Gly Ser Val Lys Ser Val Ile Lys Ser Pro Trp Xaa Leu Ala 
    850                 855                 860             


<210> 2664
<211> 50
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<400> 2664
Met Leu Ile His Gln Pro Phe Leu His Arg Gln Tyr Leu Pro Met Pro 
1               5                   10                  15      


Ala Phe Met Glu His Leu Gln Arg Arg Leu Asn Gln Asp Gly Trp Ile 
            20                  25                  30          


Asn Ser Leu Leu Lys Gly Asn Leu Ile Leu Asn Lys Pro Lys Gln Ile 
        35                  40                  45              


Xaa Ser 
    50  


<210> 2665
<211> 47
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(34)
<223> Selenocysteine

<400> 2665
Met Ser Ser Val Ser Glu Val Asn Val Asp Ile Lys Asp Phe Leu Met 
1               5                   10                  15      


Ser Ile Asn Leu Glu Gln Tyr Leu Leu His Phe His Glu Ser Gly Phe 
            20                  25                  30          


Xaa Xaa Val Lys Asp Cys Ala Ala Ile Asn Asp Ser Leu Leu Gln 
        35                  40                  45          


<210> 2666
<211> 1704
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1105)..(1105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1315)..(1315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1320)..(1320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1357)..(1357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1369)..(1369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1432)..(1432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1502)..(1502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1507)..(1507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1524)..(1524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1526)..(1526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1530)..(1530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1554)..(1554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1639)..(1639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1656)..(1656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1660)..(1660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1668)..(1668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1692)..(1692)
<223> Selenocysteine

<400> 2666
Met Ser Ser Val Ser Glu Val Asn Val Asp Ile Lys Asp Phe Leu Met 
1               5                   10                  15      


Ser Ile Asn Leu Glu Gln Tyr Leu Leu His Phe His Glu Ser Gly Phe 
            20                  25                  30          


Xaa Xaa Val Lys Asp Cys Ala Ala Ile Asn Asp Ser Leu Leu Gln Lys 
        35                  40                  45              


Ile Gly Ile Ser Pro Xaa Gly His Arg Arg Arg Ile Leu Lys Gln Leu 
    50                  55                  60                  


Gln Ile Ile Leu Ser Lys Met Gln Asp Ile Pro Ile Tyr Ala Asn Val 
65                  70                  75                  80  


His Lys Xaa Lys Lys Asn Asp Asp Pro Ser Lys Asp Tyr His Val Pro 
                85                  90                  95      


Ser Ser Asp Gln Asn Ile Cys Ile Glu Leu Ser Asn Ser Gly Ser Val 
            100                 105                 110         


Gln Xaa Ser Ser Pro Pro Gln Leu Glu Xaa Val Arg Lys Asn Leu Glu 
        115                 120                 125             


Asp Ser Asp Ala Ser Val Glu Arg Ser Gln Tyr Pro Gln Ser Asp Asp 
    130                 135                 140                 


Lys Leu Ser Pro Pro Lys Arg Asp Phe Pro Xaa Ala Glu Glu Pro His 
145                 150                 155                 160 


Leu Asn Leu Gly Ser Leu Asn Asp Ser Leu Phe Gly Ser Asp Asn Ile 
                165                 170                 175     


Lys Ile Glu Ser Leu Ile Xaa Lys Lys Xaa Val Asp His Xaa Val Glu 
            180                 185                 190         


Glu Gln Gln Xaa Glu Lys Val Lys Leu Ile Xaa Glu Asn Leu Ser Lys 
        195                 200                 205             


Leu Pro Asn Ala Asp Ser Glu Cys Leu Ser Phe Val Gly Cys Ser Xaa 
    210                 215                 220                 


Ser Gly Xaa Asn Ser Gly Asn Gly Xaa Asn Gly Leu Leu Glu Gly Ser 
225                 230                 235                 240 


Pro Pro Ser Pro Phe Phe Lys Phe Gln Gly Glu Met Ile Val Asn Asp 
                245                 250                 255     


Leu Tyr Val Pro Ser Ser Pro Ile Leu Ala Pro Val Arg Ser Arg Ser 
            260                 265                 270         


Lys Leu Val Ser Arg Pro Ser Arg Ser Phe Leu Leu Arg His Arg Pro 
        275                 280                 285             


Val Pro Glu Ile Pro Gly Ser Xaa Lys Gly Val Ser Gly Ser Tyr Phe 
    290                 295                 300                 


Arg Glu Arg Arg Asn Val Ala Xaa Ser Xaa Glu Lys Ser Val Ala Trp 
305                 310                 315                 320 


Gln Asn Ser Asn Glu Glu Asn Ser Ser Ser Ile Phe Pro Tyr Gly Glu 
                325                 330                 335     


Xaa Phe Leu Phe Gln Arg Leu Glu Asn Ser Lys Lys Arg Ser Ile Lys 
            340                 345                 350         


Asn Glu Phe Leu Xaa Gln Gly Glu Ala Leu Lys Gly Glu Ala Ala Xaa 
        355                 360                 365             


Ala Xaa Asn Ser Phe Ile Ile Lys Ser Ser Ile Tyr Asp Asn Arg Lys 
    370                 375                 380                 


Glu Lys Ile Ser Glu Asp Lys Val Glu Asp Ile Trp Ile Pro Arg Glu 
385                 390                 395                 400 


Asp Lys Asn Asn Phe Leu Ile Asp Xaa Ala Ser Glu Ser Glu Tyr Ser 
                405                 410                 415     


Xaa Val Glu Glu Cys Phe Gln Ser Leu Arg Arg Lys Asn Ser Lys Ala 
            420                 425                 430         


Ser Lys Ser Arg Xaa Gln Lys Ala Leu Ile Leu Asp Ser Val Asn Arg 
        435                 440                 445             


His Ser Tyr Pro Leu Ser Ser Xaa Ser Gly Asn Ala Asp Ser Ser Ala 
    450                 455                 460                 


Val Ser Ser Gln Ala Ile Ser Pro Tyr Ala Cys Phe Tyr Gly Ala Ser 
465                 470                 475                 480 


Ala Lys Lys Val Lys Ser Gly Trp Leu Asp Lys Leu Ser Pro Gln Gly 
                485                 490                 495     


Lys Arg Met Phe Gln Lys Arg Trp Val Lys Phe Asp Gly Leu Ser Ile 
            500                 505                 510         


Ser Tyr Tyr Asn Asn Glu Lys Glu Met Tyr Ser Lys Gly Ile Ile Pro 
        515                 520                 525             


Leu Ser Ala Ile Ser Xaa Val Arg Val Gln Gly Asp Asn Lys Phe Glu 
    530                 535                 540                 


Val Val Xaa Xaa Gln Arg Xaa Phe Val Phe Arg Val Glu Lys Glu Glu 
545                 550                 555                 560 


Glu Arg Asn Asp Trp Ile Ser Ile Leu Leu Asn Ala Leu Lys Ser Gln 
                565                 570                 575     


Ser Leu Xaa Ser Gln Ser Gln Ala Val Val Xaa Pro Glu Lys Cys Gly 
            580                 585                 590         


Tyr Leu Glu Leu Arg Gly Tyr Lys Ala Lys Ile Phe Xaa Val Leu Ser 
        595                 600                 605             


Gly Asn Ser Val Trp Leu Cys Lys Asn Glu Gln Asp Phe Lys Ser Gly 
    610                 615                 620                 


Leu Gly Ile Xaa Ile Ile Pro Met Asn Val Ala Asn Val Lys Gln Val 
625                 630                 635                 640 


Asp Arg Xaa Val Lys Gln Ser Phe Glu Ile Ile Xaa Pro Tyr Arg Ser 
                645                 650                 655     


Phe Ser Phe Xaa Ala Glu Xaa Glu Lys Glu Lys Gln Asp Trp Ile Glu 
            660                 665                 670         


Ala Val Gln Gln Ser Ile Ala Glu Xaa Leu Ser Asp Tyr Glu Val Ala 
        675                 680                 685             


Glu Lys Ile Trp Phe Asn Glu Ser Asn Arg Ser Cys Ala Asp Cys Lys 
    690                 695                 700                 


Ala Pro Asp Pro Asp Trp Ala Ser Ile Asn Leu Cys Val Val Ile Cys 
705                 710                 715                 720 


Lys Lys Cys Ala Gly Gln His Arg Ser Leu Gly Pro Lys Asp Ser Lys 
                725                 730                 735     


Val Arg Ser Leu Lys Met Asp Ala Ser Ile Trp Ser Asn Glu Leu Ile 
            740                 745                 750         


Glu Leu Phe Ile Val Ile Gly Asn Lys Arg Ala Asn Asp Phe Trp Ala 
        755                 760                 765             


Gly Asn Leu Gln Lys Asp Glu Glu Leu His Met Asp Ser Pro Val Glu 
    770                 775                 780                 


Lys Arg Lys Asn Phe Ile Xaa Gln Lys Tyr Lys Glu Gly Lys Phe Arg 
785                 790                 795                 800 


Lys Xaa Leu Leu Ala Ser Leu Xaa Lys Glu Glu Leu Asn Lys Ala Leu 
                805                 810                 815     


Cys Ala Ala Val Val Lys Pro Asp Val Leu Glu Xaa Met Ala Leu Leu 
            820                 825                 830         


Phe Ser Gly Ala Asp Val Met Cys Ala Xaa Gly Asp Pro Val His Ser 
        835                 840                 845             


Xaa Pro Tyr Leu Leu Ala Lys Lys Ala Gly Gln Ser Leu Gln Met Glu 
    850                 855                 860                 


Phe Leu Tyr His Asn Lys Phe Ser Asp Phe Pro Gln His Asp Ile His 
865                 870                 875                 880 


Ser Glu Gly Val Leu Ser Gln Glu Ser Ser Gln Ser Xaa Phe Leu Cys 
                885                 890                 895     


Asp Phe Leu Tyr Gln Ala Pro Ser Ala Ala Ser Lys Leu Ser Ser Glu 
            900                 905                 910         


Lys Lys Leu Leu Glu Glu Xaa Asn Lys Lys Trp Cys Val Leu Glu Gly 
        915                 920                 925             


Gly Phe Leu Ser Tyr Tyr Glu Asn Asp Lys Ser Xaa Xaa Pro Asn Gly 
    930                 935                 940                 


Xaa Ile Asn Ile Asn Glu Val Ile Cys Leu Ala Ile His Lys Glu Asp 
945                 950                 955                 960 


Phe Tyr Leu Asn Xaa Gly Pro Ile Phe Ile Phe Glu Ile Tyr Leu Pro 
                965                 970                 975     


Ser Glu Arg Val Phe Leu Phe Gly Ala Glu Xaa Ser Gln Ala Gln Arg 
            980                 985                 990         


Lys Trp Xaa Glu Ala Ile Ala Lys  His Phe Val Pro Leu  Phe Ala Glu 
        995                 1000                 1005             


Asn Leu  Xaa Glu Ala Asp Tyr  Asp Leu Ile Gly Gln  Leu Phe Tyr 
    1010                 1015                 1020             


Lys Asp  Cys His Ala Leu Asp  Gln Trp Arg Lys Gly  Trp Phe Ala 
    1025                 1030                 1035             


Met Asp  Lys Ser Ser Leu His  Phe Cys Leu Gln Met  Gln Glu Val 
    1040                 1045                 1050             


Gln Gly  Asp Arg Met His Leu  Arg Arg Leu Gln Glu  Leu Xaa Ile 
    1055                 1060                 1065             


Ser Xaa  Met Val Gln Asn Gly  Glu Lys Leu Asp Val  Leu Leu Leu 
    1070                 1075                 1080             


Val Glu  Lys Gly Arg Xaa Leu  Tyr Ile His Gly His  Xaa Lys Leu 
    1085                 1090                 1095             


Asp Phe  Xaa Val Trp His Xaa  Ala Ile Glu Lys Ala  Ala Gly Xaa 
    1100                 1105                 1110             


Asp Gly  Asn Ala Leu Gln Asp  Gln Gln Leu Ser Lys  Asn Asp Val 
    1115                 1120                 1125             


Pro Ile  Ile Val Asn Ser Cys  Ile Ala Phe Val Xaa  Gln Tyr Gly 
    1130                 1135                 1140             


Leu Gly  Cys Lys Tyr Ile Tyr  Gln Lys Asn Gly Asp  Pro Leu His 
    1145                 1150                 1155             


Ile Ser  Glu Leu Leu Glu Ser  Phe Lys Lys Asp Ala  Arg Ser Phe 
    1160                 1165                 1170             


Lys Leu  Arg Ala Gly Lys His  Gln Leu Glu Asp Val  Xaa Ala Val 
    1175                 1180                 1185             


Leu Lys  Ser Phe Leu Ser Asp  Ile Asp Asp Ala Leu  Leu Xaa Lys 
    1190                 1195                 1200             


Glu Leu  Tyr Pro Tyr Trp Ile  Ser Ala Leu Asp Xaa  Gln Asp Asp 
    1205                 1210                 1215             


Lys Glu  Arg Ile Lys Lys Tyr  Gly Ala Phe Ile Arg  Ser Leu Pro 
    1220                 1225                 1230             


Gly Val  Asn Arg Ala Xaa Leu  Ala Ala Ile Ile Glu  His Leu Tyr 
    1235                 1240                 1245             


Arg Val  Gln Lys Cys Ser Glu  Ile Asn His Met Asn  Ala His Asn 
    1250                 1255                 1260             


Leu Ala  Leu Val Phe Ser Ser  Cys Leu Phe Gln Xaa  Lys Gly Gln 
    1265                 1270                 1275             


Xaa Ser  Glu Glu Val Asn Val  Ile Glu Asp Leu Ile  Asn Asn Tyr 
    1280                 1285                 1290             


Val Glu  Ile Phe Glu Val Lys  Glu Asp Gln Val Lys  Gln Met Asp 
    1295                 1300                 1305             


Ile Glu  Asn Ser Phe Ile Xaa  Lys Trp Lys Asp Xaa  Gln Val Ser 
    1310                 1315                 1320             


Gln Ala  Gly Asp Leu Leu Ile  Glu Val Tyr Val Glu  Arg Lys Glu 
    1325                 1330                 1335             


Pro Asp  Cys Ser Ile Ile Ile  Arg Ile Ser Pro Val  Met Glu Ala 
    1340                 1345                 1350             


Glu Glu  Leu Xaa Asn Asp Ile  Leu Ala Ile Lys Asn  Ile Ile Pro 
    1355                 1360                 1365             


Xaa Lys  Gly Asp Ile Trp Ala  Xaa Phe Glu Val Ile  Glu Asn Glu 
    1370                 1375                 1380             


Glu Leu  Glu Arg Pro Leu His  Tyr Lys Glu Asn Val  Leu Glu Gln 
    1385                 1390                 1395             


Val Leu  Arg Trp Ser Ser Leu  Ala Glu Pro Gly Ser  Ala Tyr Leu 
    1400                 1405                 1410             


Val Val  Lys Arg Phe Leu Xaa  Ala Asp Xaa Ile Lys  His Cys Ser 
    1415                 1420                 1425             


Asp Arg  Ser Xaa Leu Gly Ser  Ile Lys Glu Gly Ile  Leu Lys Ile 
    1430                 1435                 1440             


Lys Glu  Glu Pro Ser Lys Ile  Leu Ser Gly Asn Lys  Phe Gln Asp 
    1445                 1450                 1455             


Arg Tyr  Phe Val Leu Arg Asp  Gly Phe Leu Phe Leu  Tyr Lys Asp 
    1460                 1465                 1470             


Val Lys  Ser Ser Lys His Asp  Lys Met Phe Ser Leu  Ser Ser Met 
    1475                 1480                 1485             


Lys Phe  Tyr Arg Gly Val Lys  Lys Lys Met Lys Pro  Pro Xaa Ser 
    1490                 1495                 1500             


Trp Gly  Leu Xaa Ala Tyr Ser  Glu Lys His His Trp  His Leu Cys 
    1505                 1510                 1515             


Cys Asp  Ser Ser Arg Xaa Gln  Xaa Glu Trp Met Xaa  Ser Ile Phe 
    1520                 1525                 1530             


Ile Ala  Gln His Glu Tyr Asp  Ile Trp Pro Pro Ala  Gly Lys Glu 
    1535                 1540                 1545             


Arg Lys  Arg Ser Ile Xaa Lys  Asn Pro Lys Ile Gly  Gly Leu Pro 
    1550                 1555                 1560             


Leu Ile  Pro Ile Gln His Glu  Gly Asn Ala Xaa Leu  Ala Arg Lys 
    1565                 1570                 1575             


Asn Ile  Glu Ser Ala Arg Ala  Glu Leu Glu Arg Leu  Arg Leu Ser 
    1580                 1585                 1590             


Glu Lys  Cys Asp Lys Glu Ser  Val Asp Ser Ser Leu  Lys Glu Arg 
    1595                 1600                 1605             


Ala Ser  Met Val Ala His Cys  Leu Glu His Lys Asp  Asp Lys Leu 
    1610                 1615                 1620             


Arg Asn  Arg Pro Arg Lys His  Arg Ser Phe Asn Cys  Leu Glu Asp 
    1625                 1630                 1635             


Xaa Glu  Pro Glu Ala Pro Leu  Gly Gln Pro Lys Gly  His Lys Gly 
    1640                 1645                 1650             


Leu Lys  Xaa Leu Arg Lys Xaa  Glu Asp Arg Asn Ser  Lys Ala Xaa 
    1655                 1660                 1665             


Leu Asp  Ser Asp His Lys Leu  Pro Ser Arg Val Ile  Glu Glu Leu 
    1670                 1675                 1680             


Asn Val  Val Leu Gln Arg Ser  Arg Xaa Leu Pro Lys  Glu Leu Gln 
    1685                 1690                 1695             


Asp Glu  Gln Ile Leu Lys 
    1700                 


<210> 2667
<211> 473
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<400> 2667
Met Ala Ala Pro Gln Asp Leu Asp Ile Ala Val Trp Leu Ala Xaa Val 
1               5                   10                  15      


His Leu Glu Gln Tyr Ala Asp Xaa Phe Arg Arg His Gly Leu Ala Xaa 
            20                  25                  30          


Ala Gly Ala Ala Arg Gly Leu Gly His Glu Glu Leu Lys Gln Leu Gly 
        35                  40                  45              


Ile Ser Ala Xaa Gly His Arg Lys Arg Ile Leu Arg Leu Leu Gln Xaa 
    50                  55                  60                  


Gly Xaa Glu Glu Gly Ser Leu Asp Pro Lys Ser Asp Ser Ala Met Glu 
65                  70                  75                  80  


Pro Ser Pro Ser Pro Ala Pro Gln Ala Gln Pro Pro Lys Pro Val Pro 
                85                  90                  95      


Lys Pro Arg Xaa Val Phe Gly Gly Leu Ser Gly Pro Ala Xaa Xaa Gln 
            100                 105                 110         


Arg Pro Gly Leu Ser Pro Ala Leu Gly Gly Pro Gly Val Ser Arg Ser 
        115                 120                 125             


Pro Glu Pro Ser Pro Arg Pro Pro Pro Leu Pro Xaa Ser Ser Ser Glu 
    130                 135                 140                 


Gln Ser Ser Ala Leu Asn Xaa Val Glu Met Met Pro Asn Ser Ile Tyr 
145                 150                 155                 160 


Phe Gly Leu Asp Ser Arg Gly Arg Ala Gln Ala Ala Gln Asp Lys Ala 
                165                 170                 175     


Pro Asp Ser Ser Gln Ile Ser Ala Pro Xaa Pro Ala Leu Arg Pro Xaa 
            180                 185                 190         


Xaa Gly Xaa Val His Ile Met Asp Pro Gly Cys Leu Tyr Tyr Gly Val 
        195                 200                 205             


Gln Pro Val Gly Xaa Pro Gly Ala Pro Asp Arg Arg Glu Ser Arg Gly 
    210                 215                 220                 


Val Cys Gln Gly Arg Ala Glu His Arg Leu Ser Arg Gln Asp Leu Glu 
225                 230                 235                 240 


Ala Arg Glu Asp Ala Gly Tyr Ala Ser Leu Glu Leu Pro Gly Asp Ser 
                245                 250                 255     


Xaa Leu Leu Ser Pro Xaa Leu Glu Xaa Glu Glu Xaa Ser Asp Asp Leu 
            260                 265                 270         


Ile Ser Pro Tyr Ala Ser Phe Ser Phe Xaa Ala Asp Arg Leu Xaa Pro 
        275                 280                 285             


Leu Leu Ser Gly Trp Leu Asp Lys Leu Ser Pro Gln Gly Asn Tyr Val 
    290                 295                 300                 


Phe Gln Arg Arg Phe Val Gln Phe Asn Gly Arg Ser Leu Met Tyr Phe 
305                 310                 315                 320 


Gly Ser Asp Lys Asp Pro Phe Pro Lys Gly Val Ile Pro Leu Xaa Ala 
                325                 330                 335     


Ile Glu Met Xaa Arg Ser Ser Lys Asp Asn Lys Phe Gln Val Ile Xaa 
            340                 345                 350         


Gly Gln Arg Val Phe Val Phe Arg Xaa Glu Ser Glu Ala Gln Arg Asp 
        355                 360                 365             


Met Trp Cys Ser Xaa Leu Gln Ser Cys Leu Lys Glu Gln Arg Leu Leu 
    370                 375                 380                 


Gly His Pro Arg Pro Pro Gln Pro Pro Arg Pro Leu Arg Xaa Gly Met 
385                 390                 395                 400 


Leu Glu Leu Arg Gly His Lys Ala Lys Val Phe Ala Ala Leu Ser Pro 
                405                 410                 415     


Gly Glu Leu Ala Leu Tyr Lys Ser Glu Gln Ala Phe Ser Leu Gly Ile 
            420                 425                 430         


Gly Ile Cys Phe Ile Glu Leu Gln Gly Cys Ser Val Arg Glu Xaa Lys 
        435                 440                 445             


Ser Arg Ser Phe Asp Leu Leu Xaa Pro His Arg Cys Phe Ser Phe Xaa 
    450                 455                 460                 


Ala Glu Ser Gly Gly Ala Arg Gln Ser 
465                 470             


<210> 2668
<211> 1544
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1066)..(1066)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1106)..(1107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1218)..(1218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1308)..(1308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1317)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1369)..(1369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1378)..(1378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1421)..(1421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1432)..(1432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1440)..(1440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1499)..(1500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1518)..(1518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1522)..(1522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1524)..(1524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1529)..(1529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1534)..(1534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1544)..(1544)
<223> Selenocysteine

<400> 2668
Met Ala Ala Pro Gln Asp Leu Asp Ile Ala Val Trp Leu Ala Xaa Val 
1               5                   10                  15      


His Leu Glu Gln Tyr Ala Asp Xaa Phe Arg Arg His Gly Leu Ala Xaa 
            20                  25                  30          


Ala Gly Ala Ala Arg Gly Leu Gly His Glu Glu Leu Lys Gln Leu Gly 
        35                  40                  45              


Ile Ser Ala Xaa Gly His Arg Lys Arg Ile Leu Arg Leu Leu Gln Xaa 
    50                  55                  60                  


Gly Xaa Glu Glu Gly Ser Leu Asp Pro Lys Ser Asp Ser Ala Met Glu 
65                  70                  75                  80  


Pro Ser Pro Ser Pro Ala Pro Gln Ala Gln Pro Pro Lys Pro Val Pro 
                85                  90                  95      


Lys Pro Arg Xaa Val Phe Gly Gly Leu Ser Gly Pro Ala Xaa Xaa Gln 
            100                 105                 110         


Arg Pro Gly Leu Ser Pro Ala Leu Gly Gly Pro Gly Val Ser Arg Ser 
        115                 120                 125             


Pro Glu Pro Ser Pro Arg Pro Pro Pro Leu Pro Xaa Ser Ser Ser Glu 
    130                 135                 140                 


Gln Ser Ser Ala Leu Asn Xaa Val Glu Met Met Pro Asn Ser Ile Tyr 
145                 150                 155                 160 


Phe Gly Leu Asp Ser Arg Gly Arg Ala Gln Ala Ala Gln Asp Lys Ala 
                165                 170                 175     


Pro Asp Ser Ser Gln Ile Ser Ala Pro Xaa Pro Ala Leu Arg Pro Xaa 
            180                 185                 190         


Xaa Gly Xaa Val His Ile Met Asp Pro Gly Cys Leu Tyr Tyr Gly Val 
        195                 200                 205             


Gln Pro Val Gly Xaa Pro Gly Ala Pro Asp Arg Arg Glu Ser Arg Gly 
    210                 215                 220                 


Val Cys Gln Gly Arg Ala Glu His Arg Leu Ser Arg Gln Asp Leu Glu 
225                 230                 235                 240 


Ala Arg Glu Asp Ala Gly Tyr Ala Ser Leu Glu Leu Pro Gly Asp Ser 
                245                 250                 255     


Xaa Leu Leu Ser Pro Xaa Leu Glu Xaa Glu Glu Xaa Ser Asp Asp Leu 
            260                 265                 270         


Ile Ser Pro Tyr Ala Ser Phe Ser Phe Xaa Ala Asp Arg Leu Xaa Pro 
        275                 280                 285             


Leu Leu Ser Gly Trp Leu Asp Lys Leu Ser Pro Gln Gly Asn Tyr Val 
    290                 295                 300                 


Phe Gln Arg Arg Phe Val Gln Phe Asn Gly Arg Ser Leu Met Tyr Phe 
305                 310                 315                 320 


Gly Ser Asp Lys Asp Pro Phe Pro Lys Gly Val Ile Pro Leu Xaa Ala 
                325                 330                 335     


Ile Glu Met Xaa Arg Ser Ser Lys Asp Asn Lys Phe Gln Val Ile Xaa 
            340                 345                 350         


Gly Gln Arg Val Phe Val Phe Arg Xaa Glu Ser Glu Ala Gln Arg Asp 
        355                 360                 365             


Met Trp Cys Ser Xaa Leu Gln Ser Cys Leu Lys Glu Gln Arg Leu Leu 
    370                 375                 380                 


Gly His Pro Arg Pro Pro Gln Pro Pro Arg Pro Leu Arg Xaa Gly Met 
385                 390                 395                 400 


Leu Glu Leu Arg Gly His Lys Ala Lys Val Phe Ala Ala Leu Ser Pro 
                405                 410                 415     


Gly Glu Leu Ala Leu Tyr Lys Ser Glu Gln Ala Phe Ser Leu Gly Ile 
            420                 425                 430         


Gly Ile Cys Phe Ile Glu Leu Gln Gly Cys Ser Val Arg Glu Xaa Lys 
        435                 440                 445             


Ser Arg Ser Phe Asp Leu Leu Xaa Pro His Arg Cys Phe Ser Phe Xaa 
    450                 455                 460                 


Ala Glu Ser Gly Gly Ala Arg Gln Ser Trp Ala Ala Ala Leu Gln Glu 
465                 470                 475                 480 


Ala Val Xaa Glu Xaa Leu Ser Asp Tyr Glu Val Ala Glu Lys Ile Trp 
                485                 490                 495     


Ser Asn Arg Ala Asn Arg Gln Cys Ala Asp Cys Gly Ser Ser Arg Pro 
            500                 505                 510         


Asp Trp Ala Ala Val Asn Leu Gly Val Val Ile Cys Lys Gln Cys Ala 
        515                 520                 525             


Gly Gln His Arg Ala Leu Gly Ser Gly Ile Ser Lys Val Gln Ser Leu 
    530                 535                 540                 


Lys Leu Asp Xaa Ser Val Trp Ser Asn Glu Ile Val Gln Leu Phe Ile 
545                 550                 555                 560 


Val Leu Gly Asn Asp Arg Ala Asn Arg Phe Trp Ala Gly Xaa Leu Pro 
                565                 570                 575     


Pro Gly Glu Gly Leu His Pro Asp Ala Xaa Pro Gly Pro Arg Gly Glu 
            580                 585                 590         


Phe Ile Ser Arg Lys Tyr Arg Leu Gly Leu Phe Arg Lys Pro His Pro 
        595                 600                 605             


Gln Tyr Pro Asp His Ser Gln Leu Leu Gln Ala Leu Cys Ala Ala Val 
    610                 615                 620                 


Ala Arg Pro Asn Leu Leu Lys Asn Met Xaa Gln Leu Leu Cys Val Glu 
625                 630                 635                 640 


Ala Phe Glu Gly Glu Glu Pro Trp Phe Pro Pro Ala Pro Asp Gly Ser 
                645                 650                 655     


Cys Pro Gly Leu Leu Pro Ser Asp Pro Ser Pro Gly Val Tyr Asn Glu 
            660                 665                 670         


Val Val Val Arg Ala Xaa Tyr Ser Gly Phe Leu Tyr Cys Ser Pro Val 
        675                 680                 685             


Ser Asn Lys Ala Gly Pro Ser Pro Pro Arg Arg Gly Arg Asp Ala Pro 
    690                 695                 700                 


Pro Arg Leu Trp Cys Val Leu Gly Ala Ala Leu Glu Met Phe Ala Ser 
705                 710                 715                 720 


Glu Asn Ser Pro Glu Pro Leu Ser Leu Ile Gln Pro Gln Asp Ile Val 
                725                 730                 735     


Cys Leu Gly Val Ser Pro Pro Pro Xaa Asp Pro Gly Asp Arg Phe Pro 
            740                 745                 750         


Phe Ser Phe Glu Leu Ile Leu Ala Gly Gly Arg Ile Gln His Phe Gly 
        755                 760                 765             


Xaa Asp Gly Ala Asp Ser Leu Glu Ala Trp Xaa Ser Ala Val Gly Lys 
    770                 775                 780                 


Trp Phe Ser Pro Leu Ser Cys His Gln Leu Leu Gly Pro Gly Leu Leu 
785                 790                 795                 800 


Arg Leu Gly Arg Leu Trp Leu Arg Ser Pro Ser His Xaa Ala Pro Ala 
                805                 810                 815     


Pro Gly Leu Trp Leu Ser Gly Phe Gly Leu Leu Arg Gly Asp His Leu 
            820                 825                 830         


Phe Leu Cys Ser Ala Pro Gly Pro Gly Pro Pro Ala Pro Glu Asp Met 
        835                 840                 845             


Val His Leu Arg Arg Leu Gln Glu Ile Ser Val Val Ser Ala Ala Asp 
    850                 855                 860                 


Xaa Pro Asp Lys Lys Glu His Leu Val Leu Val Glu Xaa Gly Arg Xaa 
865                 870                 875                 880 


Leu Tyr Leu Gln Gly Glu Gly Arg Leu Asp Phe Xaa Ala Trp Asn Ala 
                885                 890                 895     


Ala Ile Gly Gly Ala Ala Gly Gly Gly Gly Xaa Gly Leu Gln Glu Gln 
            900                 905                 910         


Gln Met Ser Arg Gly Asp Ile Pro Ile Ile Val Asp Ala Cys Ile Ser 
        915                 920                 925             


Phe Val Xaa Gln His Gly Leu Arg Leu Glu Gly Val Tyr Arg Lys Gly 
    930                 935                 940                 


Gly Ala Arg Ala Arg Ser Leu Arg Leu Leu Ala Glu Phe Arg Arg Asp 
945                 950                 955                 960 


Ala Arg Ser Val Lys Leu Arg Pro Gly Glu His Phe Val Glu Asp Val 
                965                 970                 975     


Xaa Asp Xaa Leu Lys Arg Phe Phe Arg Glu Leu Asp Asp Pro Val Xaa 
            980                 985                 990         


Ser Ala Arg Leu Leu Pro Arg Trp  Arg Glu Ala Ala Glu  Leu Pro Gln 
        995                 1000                 1005             


Lys Asn  Gln Arg Leu Glu Lys  Tyr Lys Asp Val Ile  Gly Cys Leu 
    1010                 1015                 1020             


Pro Arg  Val Asn Arg Arg Xaa  Leu Ala Xaa Leu Ile  Gly His Leu 
    1025                 1030                 1035             


Tyr Arg  Val Gln Lys Cys Ala  Ala Leu Asn Gln Met  Cys Xaa Arg 
    1040                 1045                 1050             


Asn Leu  Ala Leu Leu Phe Ala  Pro Ser Val Phe Gln  Xaa Asp Gly 
    1055                 1060                 1065             


Arg Gly  Glu His Glu Val Arg  Val Leu Gln Glu Leu  Ile Asp Gly 
    1070                 1075                 1080             


Tyr Ile  Ser Val Phe Asp Ile  Asp Ser Asp Gln Val  Ala Gln Ile 
    1085                 1090                 1095             


Asp Leu  Glu Val Ser Leu Ile  Xaa Xaa Trp Lys Asp  Val Gln Leu 
    1100                 1105                 1110             


Ser Gln  Ala Gly Asp Leu Ile  Met Glu Val Tyr Ile  Glu Gln Gln 
    1115                 1120                 1125             


Leu Pro  Asp Asn Cys Val Xaa  Leu Lys Val Ser Pro  Xaa Leu Xaa 
    1130                 1135                 1140             


Ala Glu  Glu Leu Xaa Asn Gln  Val Leu Glu Met Arg  Gly Xaa Ala 
    1145                 1150                 1155             


Ala Gly  Met Asp Leu Trp Val  Xaa Phe Glu Ile Arg  Glu His Gly 
    1160                 1165                 1170             


Glu Leu  Glu Arg Pro Leu His  Pro Lys Glu Lys Val  Leu Glu Gln 
    1175                 1180                 1185             


Ala Leu  Gln Trp Cys Gln Leu  Pro Glu Pro Cys Ser  Ala Ser Leu 
    1190                 1195                 1200             


Leu Leu  Lys Lys Val Pro Leu  Ala Gln Ala Gly Cys  Leu Phe Xaa 
    1205                 1210                 1215             


Gly Ile  Arg Arg Glu Ser Pro  Arg Val Gly Leu Leu  Arg Cys Arg 
    1220                 1225                 1230             


Glu Glu  Pro Pro Arg Leu Leu  Gly Ser Arg Phe Gln  Glu Arg Phe 
    1235                 1240                 1245             


Phe Leu  Leu Arg Gly Arg Cys  Leu Leu Leu Leu Lys  Glu Lys Lys 
    1250                 1255                 1260             


Ser Ser  Lys Pro Glu Arg Glu  Trp Pro Leu Glu Gly  Ala Lys Val 
    1265                 1270                 1275             


Tyr Leu  Gly Ile Arg Lys Lys  Leu Lys Pro Pro Xaa  Pro Trp Gly 
    1280                 1285                 1290             


Phe Xaa  Leu Ile Leu Glu Lys  Met His Leu Tyr Leu  Ser Cys Xaa 
    1295                 1300                 1305             


Asp Glu  Asp Glu Met Trp Asp  Trp Xaa Xaa Ser Ile  Leu Lys Ala 
    1310                 1315                 1320             


Gln His  Asp Asp Gln Gln Pro  Val Val Leu Arg Arg  His Ser Ser 
    1325                 1330                 1335             


Ser Asp  Leu Ala Arg Gln Lys  Phe Gly Xaa Met Pro  Leu Leu Pro 
    1340                 1345                 1350             


Ile Arg  Gly Asp Asp Ser Gly  Ala Xaa Leu Leu Ser  Ala Asn Gln 
    1355                 1360                 1365             


Xaa Leu  Arg Arg Leu His Asn  Arg Arg Xaa Leu Ser  Met Phe Phe 
    1370                 1375                 1380             


Pro Met  Lys Ser Ser Gln Gly  Ser Val Glu Glu Gln  Glu Glu Leu 
    1385                 1390                 1395             


Glu Glu  Pro Val Tyr Glu Glu  Pro Val Tyr Glu Glu  Val Gly Ala 
    1400                 1405                 1410             


Phe Pro  Glu Leu Ile Gln Asp  Xaa Ser Xaa Ser Phe  Ser Xaa Xaa 
    1415                 1420                 1425             


Arg Glu  Trp Xaa Val Lys Pro  Glu Asn Pro Leu Xaa  Ser Gln Lys 
    1430                 1435                 1440             


Ser Leu  Asp Gln Pro Phe Leu  Ser Lys Ser Ser Xaa  Leu Gly Gln 
    1445                 1450                 1455             


Glu Glu  Arg Pro Pro Glu Pro  Pro Pro Gly Pro Pro  Ser Lys Ser 
    1460                 1465                 1470             


Ser Pro  Gln Ala Arg Gly Ser  Leu Glu Glu Gln Leu  Leu Gln Glu 
    1475                 1480                 1485             


Leu Ser  Ser Leu Ile Leu Arg  Lys Gly Glu Xaa Xaa  Ala Gly Leu 
    1490                 1495                 1500             


Gly Ser  Pro Ser Gln Pro Ser  Ser Pro Gln Ser Pro  Ser Pro Xaa 
    1505                 1510                 1515             


Gly Leu  Pro Xaa Gln Xaa Pro  Gly Phe Pro Xaa Gln  Pro Pro Cys 
    1520                 1525                 1530             


Xaa Ser  Ser Pro Pro Ser Ser  Gln Pro Leu Xaa 
    1535                 1540                 


<210> 2669
<211> 1375
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1179)..(1179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1193)..(1193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1200)..(1200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1252)..(1252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1330)..(1331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1349)..(1349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1353)..(1353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1355)..(1355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1360)..(1360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1365)..(1365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1375)..(1375)
<223> Selenocysteine

<400> 2669
Met Glu Pro Ser Pro Ser Pro Ala Pro Gln Ala Gln Pro Pro Lys Pro 
1               5                   10                  15      


Val Pro Lys Pro Arg Xaa Val Phe Gly Gly Leu Ser Gly Pro Ala Xaa 
            20                  25                  30          


Xaa Gln Arg Pro Gly Leu Ser Pro Ala Leu Gly Gly Pro Gly Val Ser 
        35                  40                  45              


Arg Ser Pro Glu Pro Ser Pro Arg Pro Pro Pro Leu Pro Xaa Ser Ser 
    50                  55                  60                  


Ser Glu Gln Ser Ser Ala Leu Asn Xaa Val Glu Met Met Pro Asn Ser 
65                  70                  75                  80  


Ile Tyr Phe Gly Leu Asp Ser Arg Gly Arg Ala Gln Ala Ala Gln Asp 
                85                  90                  95      


Lys Ala Pro Asp Ser Ser Gln Ile Ser Ala Pro Xaa Pro Ala Leu Arg 
            100                 105                 110         


Pro Xaa Xaa Gly Xaa Val His Ile Met Asp Pro Gly Cys Leu Tyr Tyr 
        115                 120                 125             


Gly Val Gln Pro Val Gly Xaa Pro Gly Ala Pro Asp Arg Arg Glu Ser 
    130                 135                 140                 


Arg Gly Val Cys Gln Gly Arg Ala Glu His Arg Leu Ser Arg Gln Asp 
145                 150                 155                 160 


Leu Glu Ala Arg Glu Asp Ala Gly Tyr Ala Ser Leu Glu Leu Pro Gly 
                165                 170                 175     


Asp Ser Xaa Leu Leu Ser Pro Xaa Leu Glu Xaa Glu Glu Xaa Ser Asp 
            180                 185                 190         


Asp Leu Ile Ser Pro Tyr Ala Ser Phe Ser Phe Xaa Ala Asp Arg Leu 
        195                 200                 205             


Xaa Pro Leu Leu Ser Gly Trp Leu Asp Lys Leu Ser Pro Gln Gly Asn 
    210                 215                 220                 


Tyr Val Phe Gln Arg Arg Phe Val Gln Phe Asn Gly Arg Ser Leu Met 
225                 230                 235                 240 


Tyr Phe Gly Ser Asp Lys Asp Pro Phe Pro Lys Gly Val Ile Pro Leu 
                245                 250                 255     


Xaa Ala Ile Glu Met Xaa Arg Ser Ser Lys Asp Asn Lys Phe Gln Val 
            260                 265                 270         


Ile Xaa Gly Gln Arg Val Phe Val Phe Arg Xaa Glu Ser Glu Ala Gln 
        275                 280                 285             


Arg Asp Met Trp Cys Ser Xaa Leu Gln Ser Cys Leu Lys Glu Gln Arg 
    290                 295                 300                 


Leu Leu Gly His Pro Arg Pro Pro Gln Pro Pro Arg Pro Leu Arg Xaa 
305                 310                 315                 320 


Gly Met Leu Glu Leu Arg Gly His Lys Ala Lys Val Phe Ala Ala Leu 
                325                 330                 335     


Ser Pro Gly Glu Leu Ala Leu Tyr Lys Ser Glu Gln Ala Phe Ser Leu 
            340                 345                 350         


Gly Ile Gly Ile Cys Phe Ile Glu Leu Gln Gly Cys Ser Val Arg Glu 
        355                 360                 365             


Xaa Lys Ser Arg Ser Phe Asp Leu Leu Xaa Pro His Arg Cys Phe Ser 
    370                 375                 380                 


Phe Xaa Ala Glu Ser Gly Gly Ala Arg Gln Ser Trp Ala Ala Ala Leu 
385                 390                 395                 400 


Gln Glu Ala Val Xaa Glu Xaa Leu Ser Asp Tyr Glu Val Ala Glu Lys 
                405                 410                 415     


Ile Trp Ser Asn Arg Ala Asn Arg Gln Cys Ala Asp Cys Gly Ser Ser 
            420                 425                 430         


Arg Pro Asp Trp Ala Ala Val Asn Leu Gly Val Val Ile Cys Lys Gln 
        435                 440                 445             


Cys Ala Gly Gln His Arg Ala Leu Gly Ser Gly Ile Ser Lys Val Gln 
    450                 455                 460                 


Ser Leu Lys Leu Asp Xaa Ser Val Trp Ser Asn Glu Ile Val Gln Leu 
465                 470                 475                 480 


Phe Ile Val Leu Gly Asn Asp Arg Ala Asn Arg Phe Trp Ala Gly Xaa 
                485                 490                 495     


Leu Pro Pro Gly Glu Gly Leu His Pro Asp Ala Xaa Pro Gly Pro Arg 
            500                 505                 510         


Gly Glu Phe Ile Ser Arg Lys Tyr Arg Leu Gly Leu Phe Arg Lys Pro 
        515                 520                 525             


His Pro Gln Tyr Pro Asp His Ser Gln Leu Leu Gln Ala Leu Cys Ala 
    530                 535                 540                 


Ala Val Ala Arg Pro Asn Leu Leu Lys Asn Met Xaa Gln Leu Leu Cys 
545                 550                 555                 560 


Val Glu Ala Phe Glu Asp Pro Ser Pro Gly Val Tyr Asn Glu Val Val 
                565                 570                 575     


Val Arg Ala Xaa Tyr Ser Gly Phe Leu Tyr Cys Ser Pro Val Ser Asn 
            580                 585                 590         


Lys Ala Gly Pro Ser Pro Pro Arg Arg Gly Arg Asp Ala Pro Pro Arg 
        595                 600                 605             


Leu Trp Cys Val Leu Gly Ala Ala Leu Glu Met Phe Ala Ser Glu Asn 
    610                 615                 620                 


Ser Pro Glu Pro Leu Ser Leu Ile Gln Pro Gln Asp Ile Val Cys Leu 
625                 630                 635                 640 


Gly Val Ser Pro Pro Pro Xaa Asp Pro Gly Asp Arg Phe Pro Phe Ser 
                645                 650                 655     


Phe Glu Leu Ile Leu Ala Gly Gly Arg Ile Gln His Phe Gly Xaa Asp 
            660                 665                 670         


Gly Ala Asp Ser Leu Glu Ala Trp Xaa Ser Ala Val Gly Lys Trp Phe 
        675                 680                 685             


Ser Pro Leu Ser Cys His Gln Leu Leu Gly Pro Gly Leu Leu Arg Leu 
    690                 695                 700                 


Gly Arg Leu Trp Leu Arg Ser Pro Ser His Xaa Ala Pro Ala Pro Gly 
705                 710                 715                 720 


Leu Trp Leu Ser Gly Phe Gly Leu Leu Arg Gly Asp His Leu Phe Leu 
                725                 730                 735     


Cys Ser Ala Pro Gly Pro Gly Pro Pro Ala Pro Glu Asp Met Val His 
            740                 745                 750         


Leu Arg Arg Leu Gln Glu Ile Ser Val Val Ser Ala Ala Asp Xaa Pro 
        755                 760                 765             


Asp Lys Lys Glu His Leu Val Leu Val Glu Xaa Gly Arg Xaa Leu Tyr 
    770                 775                 780                 


Leu Gln Gly Glu Gly Arg Leu Asp Phe Xaa Ala Trp Asn Ala Ala Ile 
785                 790                 795                 800 


Gly Gly Ala Ala Gly Gly Gly Gly Xaa Gly Leu Gln Glu Gln Gln Met 
                805                 810                 815     


Ser Arg Gly Asp Ile Pro Ile Ile Val Asp Ala Cys Ile Ser Phe Val 
            820                 825                 830         


Xaa Gln His Glu Leu Pro Gln Lys Asn Gln Arg Leu Glu Lys Tyr Lys 
        835                 840                 845             


Asp Val Ile Gly Cys Leu Pro Arg Val Asn Arg Arg Xaa Leu Ala Xaa 
    850                 855                 860                 


Leu Ile Gly His Leu Tyr Arg Val Gln Lys Cys Ala Ala Leu Asn Gln 
865                 870                 875                 880 


Met Cys Xaa Arg Asn Leu Ala Leu Leu Phe Ala Pro Ser Val Phe Gln 
                885                 890                 895     


Xaa Asp Gly Arg Gly Glu His Glu Val Arg Val Leu Gln Glu Leu Ile 
            900                 905                 910         


Asp Gly Tyr Ile Ser Val Phe Asp Ile Asp Ser Asp Gln Val Ala Gln 
        915                 920                 925             


Ile Asp Leu Glu Val Ser Leu Ile Xaa Xaa Trp Lys Asp Val Gln Leu 
    930                 935                 940                 


Ser Gln Ala Gly Asp Leu Ile Met Glu Val Tyr Ile Glu Gln Gln Leu 
945                 950                 955                 960 


Pro Asp Asn Cys Val Xaa Leu Lys Val Ser Pro Xaa Leu Xaa Ala Glu 
                965                 970                 975     


Glu Leu Xaa Asn Gln Val Leu Glu Met Arg Gly Xaa Ala Ala Gly Met 
            980                 985                 990         


Asp Leu Trp Val Xaa Phe Glu Ile  Arg Glu His Gly Glu  Leu Glu Arg 
        995                 1000                 1005             


Pro Leu  His Pro Lys Glu Lys  Val Leu Glu Gln Ala  Leu Gln Trp 
    1010                 1015                 1020             


Cys Gln  Leu Pro Glu Pro Cys  Ser Ala Ser Leu Leu  Leu Lys Lys 
    1025                 1030                 1035             


Val Pro  Leu Ala Gln Ala Gly  Cys Leu Phe Xaa Gly  Ile Arg Arg 
    1040                 1045                 1050             


Glu Ser  Pro Arg Val Gly Leu  Leu Arg Cys Arg Glu  Glu Pro Pro 
    1055                 1060                 1065             


Arg Leu  Leu Gly Ser Arg Phe  Gln Glu Arg Phe Phe  Leu Leu Arg 
    1070                 1075                 1080             


Gly Arg  Cys Leu Leu Leu Leu  Lys Glu Lys Lys Ser  Ser Lys Pro 
    1085                 1090                 1095             


Glu Arg  Glu Trp Pro Leu Glu  Gly Ala Lys Val Tyr  Leu Gly Ile 
    1100                 1105                 1110             


Arg Lys  Lys Leu Lys Pro Pro  Xaa Pro Trp Gly Phe  Xaa Leu Ile 
    1115                 1120                 1125             


Leu Glu  Lys Met His Leu Tyr  Leu Ser Cys Xaa Asp  Glu Asp Glu 
    1130                 1135                 1140             


Met Trp  Asp Trp Xaa Xaa Ser  Ile Leu Lys Ala Gln  His Asp Asp 
    1145                 1150                 1155             


Gln Gln  Pro Val Val Leu Arg  Arg His Ser Ser Ser  Asp Leu Ala 
    1160                 1165                 1170             


Arg Gln  Lys Phe Gly Xaa Met  Pro Leu Leu Pro Ile  Arg Gly Asp 
    1175                 1180                 1185             


Asp Ser  Gly Ala Xaa Leu Leu  Ser Ala Asn Gln Xaa  Leu Arg Arg 
    1190                 1195                 1200             


Leu His  Asn Arg Arg Xaa Leu  Ser Met Phe Phe Pro  Met Lys Ser 
    1205                 1210                 1215             


Ser Gln  Gly Ser Val Glu Glu  Gln Glu Glu Leu Glu  Glu Pro Val 
    1220                 1225                 1230             


Tyr Glu  Glu Pro Val Tyr Glu  Glu Val Gly Ala Phe  Pro Glu Leu 
    1235                 1240                 1245             


Ile Gln  Asp Xaa Ser Xaa Ser  Phe Ser Xaa Xaa Arg  Glu Trp Xaa 
    1250                 1255                 1260             


Val Lys  Pro Glu Asn Pro Leu  Xaa Ser Gln Lys Ser  Leu Asp Gln 
    1265                 1270                 1275             


Pro Phe  Leu Ser Lys Ser Ser  Xaa Leu Gly Gln Glu  Glu Arg Pro 
    1280                 1285                 1290             


Pro Glu  Pro Pro Pro Gly Pro  Pro Ser Lys Ser Ser  Pro Gln Ala 
    1295                 1300                 1305             


Arg Gly  Ser Leu Glu Glu Gln  Leu Leu Gln Glu Leu  Ser Ser Leu 
    1310                 1315                 1320             


Ile Leu  Arg Lys Gly Glu Xaa  Xaa Ala Gly Leu Gly  Ser Pro Ser 
    1325                 1330                 1335             


Gln Pro  Ser Ser Pro Gln Ser  Pro Ser Pro Xaa Gly  Leu Pro Xaa 
    1340                 1345                 1350             


Gln Xaa  Pro Gly Phe Pro Xaa  Gln Pro Pro Cys Xaa  Ser Ser Pro 
    1355                 1360                 1365             


Pro Ser  Ser Gln Pro Leu Xaa  
    1370                 1375 


<210> 2670
<211> 1193
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1173)..(1173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1193)..(1193)
<223> Selenocysteine

<400> 2670
Met Xaa Arg Ser Ser Lys Asp Asn Lys Phe Gln Val Ile Xaa Gly Gln 
1               5                   10                  15      


Arg Val Phe Val Phe Arg Xaa Glu Ser Glu Ala Gln Arg Asp Met Trp 
            20                  25                  30          


Cys Ser Xaa Leu Gln Ser Cys Leu Lys Glu Gln Arg Leu Leu Gly His 
        35                  40                  45              


Pro Arg Pro Pro Gln Pro Pro Arg Pro Leu Arg Xaa Gly Met Leu Glu 
    50                  55                  60                  


Leu Arg Gly His Lys Ala Lys Val Phe Ala Ala Leu Ser Pro Gly Glu 
65                  70                  75                  80  


Leu Ala Leu Tyr Lys Ser Glu Gln Ala Phe Ser Leu Gly Ile Gly Ile 
                85                  90                  95      


Cys Phe Ile Glu Leu Gln Gly Cys Ser Val Arg Glu Xaa Lys Ser Arg 
            100                 105                 110         


Ser Phe Asp Leu Leu Xaa Pro His Arg Cys Phe Ser Phe Xaa Ala Glu 
        115                 120                 125             


Ser Gly Gly Ala Arg Gln Ser Trp Ala Ala Ala Leu Gln Glu Ala Val 
    130                 135                 140                 


Xaa Glu Xaa Leu Ser Asp Tyr Glu Val Ala Glu Lys Ile Trp Ser Asn 
145                 150                 155                 160 


Arg Ala Asn Arg Gln Cys Ala Asp Cys Gly Ser Ser Arg Pro Asp Trp 
                165                 170                 175     


Ala Ala Val Asn Leu Gly Val Val Ile Cys Lys Gln Cys Ala Gly Gln 
            180                 185                 190         


His Arg Ala Leu Gly Ser Gly Ile Ser Lys Val Gln Ser Leu Lys Leu 
        195                 200                 205             


Asp Xaa Ser Val Trp Ser Asn Glu Ile Val Gln Leu Phe Ile Val Leu 
    210                 215                 220                 


Gly Asn Asp Arg Ala Asn Arg Phe Trp Ala Gly Xaa Leu Pro Pro Gly 
225                 230                 235                 240 


Glu Gly Leu His Pro Asp Ala Xaa Pro Gly Pro Arg Gly Glu Phe Ile 
                245                 250                 255     


Ser Arg Lys Tyr Arg Leu Gly Leu Phe Arg Lys Pro His Pro Gln Tyr 
            260                 265                 270         


Pro Asp His Ser Gln Leu Leu Gln Ala Leu Cys Ala Ala Val Ala Arg 
        275                 280                 285             


Pro Asn Leu Leu Lys Asn Met Xaa Gln Leu Leu Cys Val Glu Ala Phe 
    290                 295                 300                 


Glu Gly Glu Glu Pro Trp Phe Pro Pro Ala Pro Asp Gly Ser Cys Pro 
305                 310                 315                 320 


Gly Leu Leu Pro Ser Asp Pro Ser Pro Gly Val Tyr Asn Glu Val Val 
                325                 330                 335     


Val Arg Ala Xaa Tyr Ser Gly Phe Leu Tyr Cys Ser Pro Val Ser Asn 
            340                 345                 350         


Lys Ala Gly Pro Ser Pro Pro Arg Arg Gly Arg Asp Ala Pro Pro Arg 
        355                 360                 365             


Leu Trp Cys Val Leu Gly Ala Ala Leu Glu Met Phe Ala Ser Glu Asn 
    370                 375                 380                 


Ser Pro Glu Pro Leu Ser Leu Ile Gln Pro Gln Asp Ile Val Cys Leu 
385                 390                 395                 400 


Gly Val Ser Pro Pro Pro Xaa Asp Pro Gly Asp Arg Phe Pro Phe Ser 
                405                 410                 415     


Phe Glu Leu Ile Leu Ala Gly Gly Arg Ile Gln His Phe Gly Xaa Asp 
            420                 425                 430         


Gly Ala Asp Ser Leu Glu Ala Trp Xaa Ser Ala Val Gly Lys Trp Phe 
        435                 440                 445             


Ser Pro Leu Ser Cys His Gln Leu Leu Gly Pro Gly Leu Leu Arg Leu 
    450                 455                 460                 


Gly Arg Leu Trp Leu Arg Ser Pro Ser His Xaa Ala Pro Ala Pro Gly 
465                 470                 475                 480 


Leu Trp Leu Ser Gly Phe Gly Leu Leu Arg Gly Asp His Leu Phe Leu 
                485                 490                 495     


Cys Ser Ala Pro Gly Pro Gly Pro Pro Ala Pro Glu Asp Met Val His 
            500                 505                 510         


Leu Arg Arg Leu Gln Glu Ile Ser Val Val Ser Ala Ala Asp Xaa Pro 
        515                 520                 525             


Asp Lys Lys Glu His Leu Val Leu Val Glu Xaa Gly Arg Xaa Leu Tyr 
    530                 535                 540                 


Leu Gln Gly Glu Gly Arg Leu Asp Phe Xaa Ala Trp Asn Ala Ala Ile 
545                 550                 555                 560 


Gly Gly Ala Ala Gly Gly Gly Gly Xaa Gly Leu Gln Glu Gln Gln Met 
                565                 570                 575     


Ser Arg Gly Asp Ile Pro Ile Ile Val Asp Ala Cys Ile Ser Phe Val 
            580                 585                 590         


Xaa Gln His Gly Leu Arg Leu Glu Gly Val Tyr Arg Lys Gly Gly Ala 
        595                 600                 605             


Arg Ala Arg Ser Leu Arg Leu Leu Ala Glu Phe Arg Arg Asp Ala Arg 
    610                 615                 620                 


Ser Val Lys Leu Arg Pro Gly Glu His Phe Val Glu Asp Val Xaa Asp 
625                 630                 635                 640 


Xaa Leu Lys Arg Phe Phe Arg Glu Leu Asp Asp Pro Val Xaa Ser Ala 
                645                 650                 655     


Arg Leu Leu Pro Arg Trp Arg Glu Ala Ala Glu Leu Pro Gln Lys Asn 
            660                 665                 670         


Gln Arg Leu Glu Lys Tyr Lys Asp Val Ile Gly Cys Leu Pro Arg Val 
        675                 680                 685             


Asn Arg Arg Xaa Leu Ala Xaa Leu Ile Gly His Leu Tyr Arg Val Gln 
    690                 695                 700                 


Lys Cys Ala Ala Leu Asn Gln Met Cys Xaa Arg Asn Leu Ala Leu Leu 
705                 710                 715                 720 


Phe Ala Pro Ser Val Phe Gln Xaa Asp Gly Arg Gly Glu His Glu Val 
                725                 730                 735     


Arg Val Leu Gln Glu Leu Ile Asp Gly Tyr Ile Ser Val Phe Asp Ile 
            740                 745                 750         


Asp Ser Asp Gln Val Ala Gln Ile Asp Leu Glu Val Ser Leu Ile Xaa 
        755                 760                 765             


Xaa Trp Lys Asp Val Gln Leu Ser Gln Ala Gly Asp Leu Ile Met Glu 
    770                 775                 780                 


Val Tyr Ile Glu Gln Gln Leu Pro Asp Asn Cys Val Xaa Leu Lys Val 
785                 790                 795                 800 


Ser Pro Xaa Leu Xaa Ala Glu Glu Leu Xaa Asn Gln Val Leu Glu Met 
                805                 810                 815     


Arg Gly Xaa Ala Ala Gly Met Asp Leu Trp Val Xaa Phe Glu Ile Arg 
            820                 825                 830         


Glu His Gly Glu Leu Glu Arg Pro Leu His Pro Lys Glu Lys Val Leu 
        835                 840                 845             


Glu Gln Ala Leu Gln Trp Cys Gln Leu Pro Glu Pro Cys Ser Ala Ser 
    850                 855                 860                 


Leu Leu Leu Lys Lys Val Pro Leu Ala Gln Ala Gly Cys Leu Phe Xaa 
865                 870                 875                 880 


Gly Ile Arg Arg Glu Ser Pro Arg Val Gly Leu Leu Arg Cys Arg Glu 
                885                 890                 895     


Glu Pro Pro Arg Leu Leu Gly Ser Arg Phe Gln Glu Arg Phe Phe Leu 
            900                 905                 910         


Leu Arg Gly Arg Cys Leu Leu Leu Leu Lys Glu Lys Lys Ser Ser Lys 
        915                 920                 925             


Pro Glu Arg Glu Trp Pro Leu Glu Gly Ala Lys Val Tyr Leu Gly Ile 
    930                 935                 940                 


Arg Lys Lys Leu Lys Pro Pro Xaa Pro Trp Gly Phe Xaa Leu Ile Leu 
945                 950                 955                 960 


Glu Lys Met His Leu Tyr Leu Ser Cys Xaa Asp Glu Asp Glu Met Trp 
                965                 970                 975     


Asp Trp Xaa Xaa Ser Ile Leu Lys Ala Gln His Asp Asp Gln Gln Pro 
            980                 985                 990         


Val Val Leu Arg Arg His Ser Ser  Ser Asp Leu Ala Arg  Gln Lys Phe 
        995                 1000                 1005             


Gly Xaa  Met Pro Leu Leu Pro  Ile Arg Gly Asp Asp  Ser Gly Ala 
    1010                 1015                 1020             


Xaa Leu  Leu Ser Ala Asn Gln  Xaa Leu Pro Met Lys  Ser Ser Gln 
    1025                 1030                 1035             


Gly Ser  Val Glu Glu Gln Glu  Glu Leu Glu Glu Pro  Val Tyr Glu 
    1040                 1045                 1050             


Glu Pro  Val Tyr Glu Glu Val  Gly Ala Phe Pro Glu  Leu Ile Gln 
    1055                 1060                 1065             


Asp Xaa  Ser Xaa Ser Phe Ser  Xaa Xaa Arg Glu Trp  Xaa Val Lys 
    1070                 1075                 1080             


Pro Glu  Asn Pro Leu Xaa Ser  Gln Lys Ser Leu Asp  Gln Pro Phe 
    1085                 1090                 1095             


Leu Ser  Lys Ser Ser Xaa Leu  Gly Gln Glu Glu Arg  Pro Pro Glu 
    1100                 1105                 1110             


Pro Pro  Pro Gly Pro Pro Ser  Lys Ser Ser Pro Gln  Ala Arg Gly 
    1115                 1120                 1125             


Ser Leu  Glu Glu Gln Leu Leu  Gln Glu Leu Ser Ser  Leu Ile Leu 
    1130                 1135                 1140             


Arg Lys  Gly Glu Xaa Xaa Ala  Gly Leu Gly Ser Pro  Ser Gln Pro 
    1145                 1150                 1155             


Ser Ser  Pro Gln Ser Pro Ser  Pro Xaa Gly Leu Pro  Xaa Gln Xaa 
    1160                 1165                 1170             


Pro Gly  Phe Pro Xaa Gln Pro  Pro Cys Xaa Ser Ser  Pro Pro Ser 
    1175                 1180                 1185             


Ser Gln  Pro Leu Xaa 
    1190             


<210> 2671
<211> 274
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<400> 2671
Met Arg Ala Pro Leu Leu Pro Pro Ala Pro Val Val Leu Ser Leu Leu 
1               5                   10                  15      


Ile Leu Gly Ser Gly His Tyr Ala Ala Gly Leu Asp Leu Asn Asp Xaa 
            20                  25                  30          


Tyr Ser Gly Lys Arg Glu Pro Phe Ser Gly Asp His Ser Ala Asp Gly 
        35                  40                  45              


Phe Glu Val Xaa Ser Arg Ser Glu Met Ser Ser Gly Ser Glu Ile Ser 
    50                  55                  60                  


Pro Val Ser Glu Met Pro Ser Ser Ser Glu Pro Ser Ser Gly Ala Asp 
65                  70                  75                  80  


Tyr Asp Tyr Ser Glu Glu Tyr Asp Asn Glu Pro Gln Ile Pro Gly Tyr 
                85                  90                  95      


Ile Val Asp Asp Ser Val Arg Val Glu Gln Val Val Lys Pro Pro Gln 
            100                 105                 110         


Asn Lys Xaa Glu Ser Glu Asn Xaa Ser Asp Lys Pro Lys Arg Lys Lys 
        115                 120                 125             


Lys Gly Gly Lys Asn Gly Lys Asn Arg Arg Asn Arg Lys Lys Lys Asn 
    130                 135                 140                 


Pro Cys Asn Ala Glu Phe Gln Asn Phe Cys Ile His Gly Glu Cys Lys 
145                 150                 155                 160 


Tyr Ile Glu His Leu Glu Ala Val Xaa Cys Lys Cys Gln Gln Glu Tyr 
                165                 170                 175     


Phe Gly Glu Arg Cys Gly Glu Lys Ser Met Lys Xaa His Ser Met Ile 
            180                 185                 190         


Asp Ser Ser Leu Ser Lys Ile Ala Leu Ala Ala Ile Ala Ala Phe Met 
        195                 200                 205             


Ser Ala Val Ile Leu Xaa Ala Val Ala Val Ile Xaa Val Gln Ile Ser 
    210                 215                 220                 


His Trp Ser His Cys Gln Val Ile Ala Ile Asn Asp Glu Ser Val Leu 
225                 230                 235                 240 


Phe Pro Val Asp His Lys Xaa Met Asp Pro Phe Cys Tyr Asp Gly Phe 
                245                 250                 255     


Lys Leu Ser Ile Val Xaa Phe Tyr Ala Ile Ser Val Tyr Lys Gly Ala 
            260                 265                 270         


Arg Arg 
        


<210> 2672
<211> 252
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<400> 2672
Met Arg Ala Pro Leu Leu Pro Pro Ala Pro Val Val Leu Ser Leu Leu 
1               5                   10                  15      


Ile Leu Gly Ser Gly His Tyr Ala Ala Gly Leu Asp Leu Asn Asp Xaa 
            20                  25                  30          


Tyr Ser Gly Lys Arg Glu Pro Phe Ser Gly Asp His Ser Ala Asp Gly 
        35                  40                  45              


Phe Glu Val Xaa Ser Arg Ser Glu Met Ser Ser Gly Ser Glu Ile Ser 
    50                  55                  60                  


Pro Val Ser Glu Met Pro Ser Ser Ser Glu Pro Ser Ser Gly Ala Asp 
65                  70                  75                  80  


Tyr Asp Tyr Ser Glu Glu Tyr Asp Asn Glu Pro Gln Ile Pro Gly Tyr 
                85                  90                  95      


Ile Val Asp Asp Ser Val Arg Val Glu Gln Val Val Lys Pro Pro Gln 
            100                 105                 110         


Asn Lys Xaa Glu Ser Glu Asn Xaa Ser Asp Lys Pro Lys Arg Lys Lys 
        115                 120                 125             


Lys Gly Gly Lys Asn Gly Lys Asn Arg Arg Asn Arg Lys Lys Lys Asn 
    130                 135                 140                 


Pro Cys Asn Ala Glu Phe Gln Asn Phe Cys Ile His Gly Glu Cys Lys 
145                 150                 155                 160 


Tyr Ile Glu His Leu Glu Ala Val Xaa Cys Lys Cys Gln Gln Glu Tyr 
                165                 170                 175     


Phe Gly Glu Arg Cys Gly Glu Lys Ser Met Lys Xaa His Ser Met Ile 
            180                 185                 190         


Asp Ser Ser Leu Ser Lys Ile Ala Leu Ala Ala Ile Ala Ala Phe Met 
        195                 200                 205             


Ser Ala Val Ile Leu Xaa Ala Val Ala Val Ile Xaa Val Gln Leu Arg 
    210                 215                 220                 


Arg Gln Tyr Val Arg Lys Tyr Glu Gly Glu Ala Glu Glu Arg Lys Lys 
225                 230                 235                 240 


Leu Arg Gln Glu Asn Gly Asn Val His Ala Ile Ala 
                245                 250         


<210> 2673
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<400> 2673
Met Gly Asn Ile Phe Ala Asn Leu Phe Lys Gly Leu Phe Gly Lys Lys 
1               5                   10                  15      


Glu Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Xaa Xaa Ile Pro Xaa 
        35                  40                  45              


Ile Gly Phe Asn Val Glu Xaa Val Glu Tyr Lys Asn Ile Ser Phe Xaa 
    50                  55                  60                  


Val Trp Asp Val Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His 
65                  70                  75                  80  


Tyr Phe Gln Asn Xaa Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp 
                85                  90                  95      


Arg Glu Arg Val Asn Glu Ala Arg Glu Glu Leu Met Arg Met Leu Ala 
            100                 105                 110         


Glu Asp Glu Leu Arg Asp Ala Val Leu Leu Val Phe Ala Asn Lys Gln 
        115                 120                 125             


Asp Leu Pro Asn Ala Met Asn Ala Ala Glu Ile Xaa Asp Lys Leu Gly 
    130                 135                 140                 


Leu His Ser Leu Arg His Arg Asn Trp Tyr Ile Gln Ala Xaa Cys Ala 
145                 150                 155                 160 


Xaa Ser Gly Asp Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ser Asn Gln 
                165                 170                 175     


Leu Arg Asn Gln Lys 
            180     


<210> 2674
<211> 40
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<400> 2674
Met Gly Asn Ile Phe Gly Asn Leu Leu Lys Ser Leu Ile Gly Lys Lys 
1               5                   10                  15      


Glu Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly 
        35                  40  


<210> 2675
<211> 50
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<400> 2675
Met Gly Asn Ile Phe Gly Asn Leu Leu Lys Ser Leu Ile Gly Lys Lys 
1               5                   10                  15      


Glu Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Xaa Xaa Ile Pro Xaa 
        35                  40                  45              


Ile Gly 
    50  


<210> 2676
<211> 102
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<400> 2676
Met Gly Asn Ile Phe Gly Asn Leu Leu Lys Ser Leu Ile Gly Lys Lys 
1               5                   10                  15      


Glu Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Xaa Xaa Ile Pro Xaa 
        35                  40                  45              


Ile Gly Phe Asn Val Glu Xaa Val Glu Tyr Lys Asn Ile Ser Phe Xaa 
    50                  55                  60                  


Val Trp Asp Val Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His 
65                  70                  75                  80  


Tyr Phe Gln Asn Xaa Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp 
                85                  90                  95      


Arg Glu Arg Val Asn Glu 
            100         


<210> 2677
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<400> 2677
Met Gly Asn Ile Phe Gly Asn Leu Leu Lys Ser Leu Ile Gly Lys Lys 
1               5                   10                  15      


Glu Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Xaa Xaa Ile Pro Xaa 
        35                  40                  45              


Ile Gly Phe Asn Val Glu Xaa Val Glu Tyr Lys Asn Ile Ser Phe Xaa 
    50                  55                  60                  


Val Trp Asp Val Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His 
65                  70                  75                  80  


Tyr Phe Gln Asn Xaa Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp 
                85                  90                  95      


Arg Glu Arg Val Asn Glu Ala Arg Glu Glu Leu Met Arg Met Leu Ala 
            100                 105                 110         


Glu Asp Glu Leu Arg Asp Ala Val Leu Leu Val Phe Ala Asn Lys Gln 
        115                 120                 125             


Asp Leu Pro Asn Ala Met Asn Ala Ala Glu Ile Xaa Asp Lys Leu Gly 
    130                 135                 140                 


Leu His Ser Leu Arg His Arg Asn Trp Tyr Ile Gln Ala Xaa Cys Ala 
145                 150                 155                 160 


Xaa Ser Gly Asp Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ala Asn Gln 
                165                 170                 175     


Leu Lys Asn Lys Lys 
            180     


<210> 2678
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<400> 2678
Met Gly Asn Ile Phe Gly Asn Leu Leu Lys Ser Leu Ile Gly Lys Lys 
1               5                   10                  15      


Glu Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Xaa Xaa Ile Pro Xaa 
        35                  40                  45              


Ile Gly Leu Ile Phe Val Val Asp Ser Asn Asp Arg Glu Arg Val Asn 
    50                  55                  60                  


Glu Ala Arg Glu Glu Leu Met Arg Met Leu Ala Glu Asp Glu Leu Arg 
65                  70                  75                  80  


Asp Ala Val Leu Leu Val Phe Ala Asn Lys Gln Asp Leu Pro Asn Ala 
                85                  90                  95      


Met Asn Ala Ala Glu Ile Xaa Asp Lys Leu Gly Leu His Ser Leu Arg 
            100                 105                 110         


His Arg Asn Trp Tyr Ile Gln Ala Xaa Cys Ala Xaa Ser Gly Asp Gly 
        115                 120                 125             


Leu Tyr Glu Gly Leu Asp Trp Leu Ala Asn Gln Leu Lys Asn Lys Lys 
    130                 135                 140                 


<210> 2679
<211> 22
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<400> 2679
Met Gly Leu Xaa Ile Ser Ser Leu Phe Ser Arg Leu Phe Gly Lys Lys 
1               5                   10                  15      


Gln Met Arg Ile Leu Met 
            20          


<210> 2680
<211> 153
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<400> 2680
Met Gly Leu Xaa Ile Ser Ser Leu Phe Ser Arg Leu Phe Gly Lys Lys 
1               5                   10                  15      


Gln Met Arg Ile Leu Met Gly Phe Asn Val Glu Xaa Val Glu Tyr Lys 
            20                  25                  30          


Asn Ile Cys Phe Xaa Val Trp Asp Val Gly Gly Gln Asp Arg Ile Arg 
        35                  40                  45              


Pro Leu Trp Lys His Tyr Phe Gln Asn Xaa Gln Gly Leu Ile Phe Val 
    50                  55                  60                  


Val Asp Ser Asn Asp Arg Glu Arg Ile Gln Glu Val Ala Asp Glu Leu 
65                  70                  75                  80  


Gln Lys Met Leu Leu Val Asp Glu Leu Arg Asp Ala Val Leu Leu Leu 
                85                  90                  95      


Phe Ala Asn Lys Gln Asp Leu Pro Asn Ala Met Ala Ile Ser Glu Met 
            100                 105                 110         


Xaa Asp Lys Leu Gly Leu Gln Ser Leu Arg Asn Arg Xaa Trp Tyr Val 
        115                 120                 125             


Gln Ala Xaa Cys Ala Xaa Gln Gly Xaa Gly Leu Tyr Glu Gly Leu Asp 
    130                 135                 140                 


Trp Leu Ser Asn Glu Leu Ser Lys Arg 
145                 150             


<210> 2681
<211> 59
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<400> 2681
Met Gly Leu Xaa Ile Ser Ser Leu Phe Ser Arg Leu Phe Gly Lys Lys 
1               5                   10                  15      


Gln Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Xaa Xaa Ile Pro Xaa 
        35                  40                  45              


Ile Ala Val Ile Phe Val Phe Leu Cys Arg Phe 
    50                  55                  


<210> 2682
<211> 127
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<400> 2682
Met Gly Leu Xaa Ile Ser Ser Leu Phe Ser Arg Leu Phe Gly Lys Lys 
1               5                   10                  15      


Gln Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Xaa Xaa Ile Pro Xaa 
        35                  40                  45              


Ile Gly Phe Asn Val Glu Xaa Val Glu Tyr Lys Asn Ile Cys Phe Xaa 
    50                  55                  60                  


Val Trp Asp Val Gly Gly Gln Asp Arg Ile Arg Pro Leu Trp Lys His 
65                  70                  75                  80  


Tyr Phe Gln Asn Xaa Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp 
                85                  90                  95      


Arg Glu Arg Ile Gln Glu Val Ala Asp Glu Leu Gln Lys Met Leu Leu 
            100                 105                 110         


Val Asp Glu Leu Arg Asp Ala Val Leu Leu Leu Phe Ala Asn Lys 
        115                 120                 125         


<210> 2683
<211> 180
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<400> 2683
Met Gly Leu Xaa Ile Ser Ser Leu Phe Ser Arg Leu Phe Gly Lys Lys 
1               5                   10                  15      


Gln Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Xaa Xaa Ile Pro Xaa 
        35                  40                  45              


Ile Gly Phe Asn Val Glu Xaa Val Glu Tyr Lys Asn Ile Cys Phe Xaa 
    50                  55                  60                  


Val Trp Asp Val Gly Gly Gln Asp Arg Ile Arg Pro Leu Trp Lys His 
65                  70                  75                  80  


Tyr Phe Gln Asn Xaa Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp 
                85                  90                  95      


Arg Glu Arg Ile Gln Glu Val Ala Asp Glu Leu Gln Lys Met Leu Leu 
            100                 105                 110         


Val Asp Glu Leu Arg Asp Ala Val Leu Leu Leu Phe Ala Asn Lys Gln 
        115                 120                 125             


Asp Leu Pro Asn Ala Met Ala Ile Ser Glu Met Xaa Asp Lys Leu Gly 
    130                 135                 140                 


Leu Gln Ser Leu Arg Asn Arg Xaa Trp Tyr Val Gln Ala Xaa Cys Ala 
145                 150                 155                 160 


Xaa Gln Gly Xaa Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ser Asn Glu 
                165                 170                 175     


Leu Ser Lys Arg 
            180 


<210> 2684
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<400> 2684
Met Leu Leu Val Asp Glu Leu Arg Asp Ala Val Leu Leu Leu Phe Ala 
1               5                   10                  15      


Asn Lys Gln Asp Leu Pro Asn Ala Met Ala Ile Ser Glu Met Xaa Asp 
            20                  25                  30          


Lys Leu Gly Leu Gln Ser Leu Arg Asn Arg Xaa Trp Tyr Val Gln Ala 
        35                  40                  45              


Xaa Cys Ala Xaa Gln Gly Xaa Gly Leu Tyr Glu Gly Leu Asp Trp Leu 
    50                  55                  60                  


Ser Asn Glu Leu Ser Lys Arg 
65                  70      


<210> 2685
<211> 150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 2685
Met Gly Leu Xaa Val Ser Ala Leu Phe Ser Arg Ile Phe Gly Lys Lys 
1               5                   10                  15      


Gln Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Xaa Xaa Ile Pro Xaa 
        35                  40                  45              


Ile Gly Phe Asn Val Glu Xaa Val Glu Tyr Lys Asn Ile Cys Phe Xaa 
    50                  55                  60                  


Val Trp Asp Val Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His 
65                  70                  75                  80  


Tyr Phe Gln Asn Xaa Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp 
                85                  90                  95      


Arg Glu Arg Val Gln Glu Ser Ala Asp Glu Leu Gln Lys Met Glu Asp 
            100                 105                 110         


Glu Leu Arg Asp Ala Val Leu Leu Val Phe Ala Asn Lys Gln Asp Met 
        115                 120                 125             


Pro Asn Ala Met Pro Val Ser Glu Leu Xaa Asp Lys Leu Gly Leu Gln 
    130                 135                 140                 


His Leu Arg Ser Arg Xaa 
145                 150 


<210> 2686
<211> 180
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<400> 2686
Met Gly Leu Xaa Val Ser Ala Leu Phe Ser Arg Ile Phe Gly Lys Lys 
1               5                   10                  15      


Gln Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Xaa Xaa Ile Pro Xaa 
        35                  40                  45              


Ile Gly Phe Asn Val Glu Xaa Val Glu Tyr Lys Asn Ile Cys Phe Xaa 
    50                  55                  60                  


Val Trp Asp Val Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His 
65                  70                  75                  80  


Tyr Phe Gln Asn Xaa Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp 
                85                  90                  95      


Arg Glu Arg Val Gln Glu Ser Ala Asp Glu Leu Gln Lys Met Leu Gln 
            100                 105                 110         


Glu Asp Glu Leu Arg Asp Ala Val Leu Leu Val Phe Ala Asn Lys Gln 
        115                 120                 125             


Asp Met Pro Asn Ala Met Pro Val Ser Glu Leu Xaa Asp Lys Leu Gly 
    130                 135                 140                 


Leu Gln His Leu Arg Ser Arg Xaa Trp Tyr Val Gln Ala Xaa Cys Ala 
145                 150                 155                 160 


Xaa Gln Gly Xaa Gly Leu Tyr Asp Gly Leu Asp Trp Leu Ser His Glu 
                165                 170                 175     


Leu Ser Lys Arg 
            180 


<210> 2687
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<400> 2687
Met Gly Lys Val Leu Ser Lys Ile Phe Gly Asn Lys Glu Met Arg Ile 
1               5                   10                  15      


Leu Met Leu Gly Leu Asp Ala Ala Gly Lys Xaa Xaa Ile Leu Tyr Lys 
            20                  25                  30          


Leu Lys Leu Gly Gln Ser Val Xaa Xaa Ile Pro Xaa Val Gly Phe Asn 
        35                  40                  45              


Val Glu Xaa Val Xaa Tyr Lys Asn Val Lys Phe Asn Val Trp Asp Val 
    50                  55                  60                  


Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His Tyr Tyr Xaa Gly 
65                  70                  75                  80  


Xaa Gln Gly Leu Ile Phe Val Val Asp Cys Ala Asp Arg Asp Arg Ile 
                85                  90                  95      


Asp Glu Ala Arg Gln Glu Leu His Arg Ile Ile Asn Asp Arg Glu Met 
            100                 105                 110         


Arg Asp Ala Ile Ile Leu Ile Phe Ala Asn Lys Gln Asp Leu Pro Asp 
        115                 120                 125             


Ala Met Lys Pro His Glu Ile Gln Glu Lys Leu Gly Leu Xaa Arg Ile 
    130                 135                 140                 


Arg Asp Arg Asn Trp Tyr Val Gln Pro Ser Cys Ala Xaa Ser Gly Asp 
145                 150                 155                 160 


Gly Leu Tyr Glu Gly Leu Xaa Trp Leu Xaa Ser Asn Tyr Lys Ser 
                165                 170                 175 


<210> 2688
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<400> 2688
Met Tyr Glu Gly Lys Lys Xaa Lys Asn Met Phe Leu Xaa Arg Ala Leu 
1               5                   10                  15      


Glu Lys Ile Leu Ala Asp Lys Glu Val Lys Lys Ala His His Ser Gln 
            20                  25                  30          


Leu Arg Lys Ala Cys Glu Val Ala Leu Glu Glu Ile Lys Ala Glu Xaa 
        35                  40                  45              


Glu Lys Gln Ser Pro Pro His Gly Glu Ala Lys Ala Gly Ser Ser Xaa 
    50                  55                  60                  


Leu Pro Pro Val Lys Ser Lys Xaa Asn Phe Ile Glu Ala Asp Lys Tyr 
65                  70                  75                  80  


Phe Leu Pro Phe Glu Leu Ala Cys Gln Ser Lys Cys Pro Arg Ile Val 
                85                  90                  95      


Ser Xaa Ser Leu Asp Cys Leu Gln Lys Leu Ile Ala Tyr Gly His Leu 
            100                 105                 110         


Xaa Gly Asn Ala Pro Asp 
        115             


<210> 2689
<211> 1849
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1007)..(1007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1083)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1300)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1306)..(1306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1316)..(1316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1339)..(1339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1365)..(1365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1402)..(1402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1406)..(1406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1418)..(1418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1452)..(1454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1467)..(1467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1501)..(1501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1516)..(1516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1523)..(1523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1527)..(1527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1533)..(1534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1541)..(1541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1549)..(1549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1564)..(1564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1605)..(1605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1630)..(1630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1665)..(1665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1675)..(1675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1704)..(1704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1724)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1767)..(1767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1769)..(1769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1778)..(1778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1786)..(1786)
<223> Selenocysteine

<400> 2689
Met Tyr Glu Gly Lys Lys Xaa Lys Asn Met Phe Leu Xaa Arg Ala Leu 
1               5                   10                  15      


Glu Lys Ile Leu Ala Asp Lys Glu Val Lys Lys Ala His His Ser Gln 
            20                  25                  30          


Leu Arg Lys Ala Cys Glu Val Ala Leu Glu Glu Ile Lys Ala Glu Xaa 
        35                  40                  45              


Glu Lys Gln Ser Pro Pro His Gly Glu Ala Lys Ala Gly Ser Ser Xaa 
    50                  55                  60                  


Leu Pro Pro Val Lys Ser Lys Xaa Asn Phe Ile Glu Ala Asp Lys Tyr 
65                  70                  75                  80  


Phe Leu Pro Phe Glu Leu Ala Cys Gln Ser Lys Cys Pro Arg Ile Val 
                85                  90                  95      


Ser Xaa Ser Leu Asp Cys Leu Gln Lys Leu Ile Ala Tyr Gly His Leu 
            100                 105                 110         


Xaa Gly Asn Ala Pro Asp Ser Xaa Xaa Pro Gly Lys Lys Leu Ile Asp 
        115                 120                 125             


Arg Ile Ile Glu Xaa Ile Cys Gly Cys Phe Gln Gly Pro Gln Xaa Asp 
    130                 135                 140                 


Glu Gly Val Gln Leu Gln Ile Ile Lys Ala Leu Leu Xaa Ala Val Xaa 
145                 150                 155                 160 


Ser Gln His Ile Glu Ile His Glu Gly Xaa Val Leu Gln Ala Val Arg 
                165                 170                 175     


Xaa Cys Tyr Asn Ile Tyr Leu Ala Ser Lys Asn Leu Ile Asn Gln Xaa 
            180                 185                 190         


Xaa Ala Lys Ala Xaa Leu Xaa Gln Met Leu Asn Val Ile Phe Ala Arg 
        195                 200                 205             


Met Glu Asn Gln Ala Leu Gln Glu Ala Lys Gln Met Glu Lys Glu Arg 
    210                 215                 220                 


His Arg Gln His His His Leu Leu Gln Ser Pro Val Ser His His Glu 
225                 230                 235                 240 


Pro Glu Ser Pro Gln Leu Arg Tyr Leu Pro Pro Gln Xaa Val Asp His 
                245                 250                 255     


Ile Ser Gln Glu His Glu Gly Asp Leu Asp Leu His Xaa Asn Asp Val 
            260                 265                 270         


Asp Lys Ser Leu Gln Asp Asp Xaa Glu Pro Glu Asn Gly Ser Asp Ile 
        275                 280                 285             


Ser Ser Ala Glu Asn Glu Gln Xaa Glu Ala Asp Gln Ala Xaa Ala Ala 
    290                 295                 300                 


Glu Xaa Leu Ser Lys Asn Glu Val Leu Tyr Asp Gly Glu Asn His Asp 
305                 310                 315                 320 


Cys Glu Glu Lys Pro Gln Asp Ile Val Gln Asn Ile Val Glu Glu Met 
                325                 330                 335     


Val Asn Ile Val Val Gly Asp Met Gly Glu Gly Xaa Xaa Ile Asn Ala 
            340                 345                 350         


Ser Ala Asp Gly Asn Ile Gly Xaa Ile Glu Asp Gly Ser Asp Ser Glu 
        355                 360                 365             


Asn Ile Gln Ala Asn Gly Ile Pro Gly Xaa Pro Ile Ser Val Ala Tyr 
    370                 375                 380                 


Xaa Pro Ser Leu Pro Asp Asp Arg Leu Ser Val Ser Ser Asn Asp Xaa 
385                 390                 395                 400 


Gln Glu Ser Gly Asn Ser Ser Gly Pro Ser Pro Gly Ala Lys Phe Ser 
                405                 410                 415     


His Ile Leu Gln Lys Asp Ala Phe Leu Val Phe Arg Ser Leu Cys Lys 
            420                 425                 430         


Leu Ser Met Lys Pro Leu Ser Asp Gly Pro Pro Asp Pro Lys Ser His 
        435                 440                 445             


Glu Leu Arg Ser Lys Ile Leu Ser Leu Gln Leu Leu Leu Ser Ile Leu 
    450                 455                 460                 


Gln Asn Ala Gly Pro Ile Phe Arg Xaa Asn Glu Met Phe Ile Asn Ala 
465                 470                 475                 480 


Ile Lys Gln Tyr Leu Cys Val Ala Leu Ser Lys Asn Gly Val Ser Ser 
                485                 490                 495     


Val Pro Glu Val Phe Glu Leu Ser Leu Ser Ile Phe Leu Xaa Leu Leu 
            500                 505                 510         


Ser Asn Phe Lys Xaa His Leu Lys Met Gln Ile Glu Val Phe Phe Lys 
        515                 520                 525             


Glu Ile Phe Leu Tyr Ile Leu Glu Xaa Ser Xaa Ser Ser Phe Asp His 
    530                 535                 540                 


Lys Trp Met Val Ile Gln Xaa Leu Xaa Arg Ile Cys Ala Asp Ala Gln 
545                 550                 555                 560 


Ser Val Val Asp Ile Tyr Val Asn Tyr Asp Cys Asp Leu Asn Ala Ala 
                565                 570                 575     


Asn Ile Phe Glu Arg Leu Val Asn Asp Leu Ser Lys Ile Ala Gln Gly 
            580                 585                 590         


Arg Gly Ser Gln Glu Leu Gly Met Ser Asn Val Gln Glu Leu Ser Leu 
        595                 600                 605             


Arg Lys Lys Gly Leu Glu Cys Leu Val Ser Ile Leu Lys Cys Met Val 
    610                 615                 620                 


Glu Trp Ser Lys Asp Gln Tyr Val Asn Pro Asn Ser Gln Xaa Xaa Leu 
625                 630                 635                 640 


Gly Gln Glu Lys Pro Ser Glu Gln Glu Met Ser Glu Ile Lys His Pro 
                645                 650                 655     


Glu Xaa Ile Asn Arg Tyr Gly Ser Leu Asn Ser Leu Glu Ser Xaa Ser 
            660                 665                 670         


Ser Ser Gly Ile Gly Ser Tyr Ser Xaa Gln Met Ser Gly Xaa Asp Asn 
        675                 680                 685             


Pro Glu Gln Phe Glu Val Leu Lys Gln Gln Lys Glu Ile Ile Glu Gln 
    690                 695                 700                 


Gly Ile Asp Leu Phe Asn Lys Lys Pro Lys Arg Gly Ile Gln Tyr Leu 
705                 710                 715                 720 


Gln Glu Gln Gly Met Leu Gly Xaa Xaa Pro Glu Asp Ile Ala Gln Phe 
                725                 730                 735     


Leu His Gln Glu Glu Arg Leu Asp Ser Xaa Gln Val Gly Glu Phe Leu 
            740                 745                 750         


Gly Asp Asn Asp Lys Phe Asn Lys Glu Val Met Tyr Ala Tyr Val Asp 
        755                 760                 765             


Gln His Asp Phe Ser Gly Lys Asp Phe Val Ser Ala Leu Arg Met Phe 
    770                 775                 780                 


Leu Glu Gly Phe Arg Leu Pro Gly Glu Ala Gln Lys Ile Asp Arg Leu 
785                 790                 795                 800 


Met Glu Lys Phe Ala Ala Arg Tyr Leu Glu Cys Asn Gln Gly Gln Xaa 
                805                 810                 815     


Leu Phe Ala Ser Ala Asp Xaa Ala Tyr Val Leu Ala Tyr Ser Ile Ile 
            820                 825                 830         


Met Leu Xaa Xaa Asp Leu His Ser Pro Gln Val Lys Asn Lys Met Xaa 
        835                 840                 845             


Lys Glu Gln Tyr Ile Lys Met Asn Arg Gly Ile Asn Asp Ser Lys Asp 
    850                 855                 860                 


Leu Pro Glu Glu Tyr Leu Ser Ala Ile Tyr Asn Glu Ile Ala Gly Lys 
865                 870                 875                 880 


Lys Ile Ser Met Lys Glu Xaa Lys Glu Leu Xaa Ile Pro Xaa Lys Ser 
                885                 890                 895     


Ser Lys Gln Asn Val Ala Ser Glu Lys Gln Arg Arg Leu Leu Tyr Asn 
            900                 905                 910         


Leu Glu Met Glu Gln Met Ala Lys Xaa Ala Lys Ala Leu Met Glu Ala 
        915                 920                 925             


Val Ser His Val Gln Ala Pro Phe Xaa Ser Ala Xaa His Leu Glu His 
    930                 935                 940                 


Val Arg Pro Met Phe Lys Leu Ala Trp Xaa Pro Phe Leu Ala Ala Phe 
945                 950                 955                 960 


Ser Val Gly Leu Gln Asp Cys Asp Asp Xaa Glu Val Ala Ser Leu Cys 
                965                 970                 975     


Leu Glu Gly Ile Arg Cys Ala Ile Arg Ile Ala Cys Ile Phe Ser Ile 
            980                 985                 990         


Gln Leu Glu Arg Asp Ala Tyr Val  Gln Ala Leu Ala Arg  Phe Xaa Leu 
        995                 1000                 1005             


Leu Xaa  Val Ser Ser Gly Ile  Xaa Glu Met Lys Gln  Lys Asn Ile 
    1010                 1015                 1020             


Asp Xaa  Ile Lys Xaa Leu Ile  Xaa Val Ala His Xaa  Asp Gly Asn 
    1025                 1030                 1035             


Tyr Leu  Gly Asn Ser Trp His  Glu Ile Leu Lys Cys  Ile Ser Gln 
    1040                 1045                 1050             


Leu Glu  Leu Ala Gln Leu Ile  Gly Xaa Gly Val Lys  Pro Arg Tyr 
    1055                 1060                 1065             


Ile Ser  Gly Xaa Val Arg Gly  Arg Glu Gly Ser Leu  Xaa Gly Xaa 
    1070                 1075                 1080             


Lys Asp  Gln Ala Pro Asp Glu  Phe Val Gly Leu Gly  Leu Val Gly 
    1085                 1090                 1095             


Gly Asn  Val Asp Trp Lys Gln  Ile Ala Ser Ile Gln  Glu Ser Ile 
    1100                 1105                 1110             


Gly Glu  Xaa Ser Ser Gln Ser  Val Val Val Ala Val  Asp Arg Ile 
    1115                 1120                 1125             


Phe Xaa  Gly Ser Xaa Arg Leu  Asp Gly Asn Ala Ile  Val Asp Phe 
    1130                 1135                 1140             


Val Arg  Trp Leu Cys Ala Val  Ser Met Asp Glu Leu  Leu Ser Xaa 
    1145                 1150                 1155             


Xaa His  Pro Arg Met Phe Ser  Leu Gln Lys Ile Val  Glu Ile Ser 
    1160                 1165                 1170             


Tyr Tyr  Asn Met Gly Arg Ile  Arg Leu Gln Trp Ser  Arg Ile Trp 
    1175                 1180                 1185             


Glu Val  Ile Gly Asp His Phe  Asn Lys Val Gly Cys  Asn Pro Asn 
    1190                 1195                 1200             


Glu Asp  Val Ala Ile Phe Ala  Val Asp Ser Leu Arg  Gln Leu Ser 
    1205                 1210                 1215             


Met Lys  Phe Leu Glu Lys Gly  Glu Leu Ala Asn Phe  Arg Phe Gln 
    1220                 1225                 1230             


Lys Asp  Phe Leu Arg Pro Phe  Glu His Ile Met Lys  Arg Asn Arg 
    1235                 1240                 1245             


Ser Pro  Xaa Ile Arg Asp Met  Val Val Arg Cys Ile  Ala Gln Met 
    1250                 1255                 1260             


Val Asn  Ser Gln Ala Ala Asn  Ile Arg Ser Gly Trp  Lys Asn Ile 
    1265                 1270                 1275             


Phe Ser  Val Phe His Leu Ala  Ala Ser Asp Gln Asp  Glu Ser Ile 
    1280                 1285                 1290             


Val Glu  Leu Ala Phe Gln Xaa  Xaa Gly His Ile Val  Xaa Leu Val 
    1295                 1300                 1305             


Phe Glu  Lys His Phe Pro Ala  Xaa Ile Asp Ser Phe  Gln Asp Ala 
    1310                 1315                 1320             


Val Lys  Cys Leu Ser Glu Phe  Ala Cys Asn Ala Ala  Phe Pro Asp 
    1325                 1330                 1335             


Xaa Ser  Met Glu Ala Ile Arg  Leu Ile Arg His Cys  Ala Lys Tyr 
    1340                 1345                 1350             


Val Ser  Asp Arg Pro Gln Ala  Phe Lys Glu Tyr Xaa  Ser Asp Asp 
    1355                 1360                 1365             


Met Asn  Val Ala Pro Glu Asp  Arg Val Trp Val Arg  Gly Trp Phe 
    1370                 1375                 1380             


Pro Ile  Leu Phe Glu Leu Ser  Cys Ile Ile Asn Arg  Cys Lys Leu 
    1385                 1390                 1395             


Asp Val  Arg Xaa Arg Gly Leu  Xaa Val Met Phe Glu  Ile Met Lys 
    1400                 1405                 1410             


Xaa Tyr  Gly His Xaa Tyr Glu  Lys His Trp Trp Gln  Asp Leu Phe 
    1415                 1420                 1425             


Arg Ile  Val Phe Arg Ile Phe  Asp Asn Met Lys Leu  Pro Glu Gln 
    1430                 1435                 1440             


Gln Xaa  Glu Lys Ala Glu Trp  Met Xaa Xaa Xaa Cys  Asn His Ala 
    1445                 1450                 1455             


Leu Tyr  Ala Ile Cys Asp Val  Phe Xaa Gln Tyr Leu  Glu Val Leu 
    1460                 1465                 1470             


Ser Asp  Val Leu Leu Asp Asp  Ile Phe Ala Gln Leu  Tyr Trp Cys 
    1475                 1480                 1485             


Val Gln  Gln Asp Asn Glu Gln  Leu Ala Arg Ser Gly  Xaa Asn Cys 
    1490                 1495                 1500             


Leu Glu  Asn Val Val Ile Leu  Asn Gly Glu Lys Phe  Xaa Leu Glu 
    1505                 1510                 1515             


Ile Trp  Asp Lys Xaa Cys Asn  Cys Xaa Leu Asp Ile  Phe Lys Xaa 
    1520                 1525                 1530             


Xaa Ile  Pro His Ala Leu Leu  Xaa Trp Arg Pro Asn  Ser Gly Glu 
    1535                 1540                 1545             


Xaa Ala  Pro Pro Pro Pro Ser  Pro Val Ser Glu Lys  Pro Leu Asp 
    1550                 1555                 1560             


Xaa Ile  Ser Gln Lys Ser Val  Asp Ile His Asp Ser  Ile Gln Pro 
    1565                 1570                 1575             


Arg Ser  Val Asp Asn Arg Pro  Gln Ala Pro Leu Val  Ser Ala Ser 
    1580                 1585                 1590             


Ala Val  Asn Glu Glu Val Ser  Lys Ile Lys Ser Xaa  Ala Lys Phe 
    1595                 1600                 1605             


Pro Glu  Gln Lys Leu Phe Ala  Ala Leu Leu Ile Lys  Cys Val Val 
    1610                 1615                 1620             


Gln Leu  Glu Leu Ile Gln Xaa  Ile Asp Asn Ile Val  Phe Phe Pro 
    1625                 1630                 1635             


Ala Xaa  Ser Lys Lys Glu Asp  Ala Glu Asn Leu Ala  Ala Ala Gln 
    1640                 1645                 1650             


Arg Asp  Ala Val Asp Phe Asp  Val Arg Val Asp Xaa  Gln Asp Gln 
    1655                 1660                 1665             


Gly Met  Tyr Arg Phe Leu Xaa  Ser Gln Gln Leu Phe  Lys Leu Leu 
    1670                 1675                 1680             


Asp Cys  Leu Leu Glu Ser His  Arg Phe Ala Lys Ala  Phe Asn Ser 
    1685                 1690                 1695             


Asn Asn  Glu Gln Arg Xaa Ala  Leu Trp Lys Ala Gly  Phe Lys Gly 
    1700                 1705                 1710             


Lys Ser  Lys Pro Asn Leu Leu  Lys Gln Glu Xaa Ser  Ser Leu Ala 
    1715                 1720                 1725             


Cys Gly  Leu Arg Ile Leu Phe  Arg Met Tyr Met Asp  Glu Ser Arg 
    1730                 1735                 1740             


Val Ser  Ala Trp Glu Glu Val  Gln Gln Arg Leu Leu  Asn Val Cys 
    1745                 1750                 1755             


Ser Glu  Ala Leu Ser Tyr Phe  Leu Xaa Leu Xaa Ser  Glu Ser His 
    1760                 1765                 1770             


Arg Glu  Ala Trp Xaa Asn Leu  Leu Leu Leu Phe Leu  Xaa Lys Val 
    1775                 1780                 1785             


Leu Lys  Ile Ser Asp Asn Arg  Phe Lys Ala His Ala  Ser Phe Tyr 
    1790                 1795                 1800             


Tyr Pro  Leu Leu Cys Glu Ile  Met Gln Phe Asp Leu  Ile Pro Glu 
    1805                 1810                 1815             


Leu Arg  Ala Val Leu Arg Arg  Phe Phe Leu Arg Ile  Gly Val Val 
    1820                 1825                 1830             


Phe Gln  Ile Ser Gln Pro Pro  Glu Gln Glu Leu Gly  Ile Asn Lys 
    1835                 1840                 1845             


Gln 
    


<210> 2690
<211> 825
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<400> 2690
Xaa Gly Asn Ser Trp His Glu Ile Leu Lys Cys Ile Ser Gln Leu Glu 
1               5                   10                  15      


Leu Ala Gln Leu Ile Gly Xaa Gly Val Lys Pro Arg Tyr Ile Ser Gly 
            20                  25                  30          


Xaa Val Arg Gly Arg Glu Gly Ser Leu Xaa Gly Xaa Lys Asp Gln Ala 
        35                  40                  45              


Pro Asp Glu Phe Val Gly Leu Gly Leu Val Gly Gly Asn Val Asp Trp 
    50                  55                  60                  


Lys Gln Ile Ala Ser Ile Gln Glu Ser Ile Gly Glu Xaa Ser Ser Gln 
65                  70                  75                  80  


Ser Val Val Val Ala Val Asp Arg Ile Phe Xaa Gly Ser Xaa Arg Leu 
                85                  90                  95      


Asp Gly Asn Ala Ile Val Asp Phe Val Arg Trp Leu Cys Ala Val Ser 
            100                 105                 110         


Met Asp Glu Leu Leu Ser Xaa Xaa His Pro Arg Met Phe Ser Leu Gln 
        115                 120                 125             


Lys Ile Val Glu Ile Ser Tyr Tyr Asn Met Gly Arg Ile Arg Leu Gln 
    130                 135                 140                 


Trp Ser Arg Ile Trp Glu Val Ile Gly Asp His Phe Asn Lys Val Gly 
145                 150                 155                 160 


Cys Asn Pro Asn Glu Asp Val Ala Ile Phe Ala Val Asp Ser Leu Arg 
                165                 170                 175     


Gln Leu Ser Met Lys Phe Leu Glu Lys Gly Glu Leu Ala Asn Phe Arg 
            180                 185                 190         


Phe Gln Lys Asp Phe Leu Arg Pro Phe Glu His Ile Met Lys Arg Asn 
        195                 200                 205             


Arg Ser Pro Xaa Ile Arg Asp Met Val Val Arg Cys Ile Ala Gln Met 
    210                 215                 220                 


Val Asn Ser Gln Ala Ala Asn Ile Arg Ser Gly Trp Lys Asn Ile Phe 
225                 230                 235                 240 


Ser Val Phe His Leu Ala Ala Ser Asp Gln Asp Glu Ser Ile Val Glu 
                245                 250                 255     


Leu Ala Phe Gln Xaa Xaa Gly His Ile Val Xaa Leu Val Phe Glu Lys 
            260                 265                 270         


His Phe Pro Ala Xaa Ile Asp Ser Phe Gln Asp Ala Val Lys Cys Leu 
        275                 280                 285             


Ser Glu Phe Ala Cys Asn Ala Ala Phe Pro Asp Xaa Ser Met Glu Ala 
    290                 295                 300                 


Ile Arg Leu Ile Arg His Cys Ala Lys Tyr Val Ser Asp Arg Pro Gln 
305                 310                 315                 320 


Ala Phe Lys Glu Tyr Xaa Ser Asp Asp Met Asn Val Ala Pro Glu Asp 
                325                 330                 335     


Arg Val Trp Val Arg Gly Trp Phe Pro Ile Leu Phe Glu Leu Ser Cys 
            340                 345                 350         


Ile Ile Asn Arg Cys Lys Leu Asp Val Arg Xaa Arg Gly Leu Xaa Val 
        355                 360                 365             


Met Phe Glu Ile Met Lys Xaa Tyr Gly His Xaa Tyr Glu Lys His Trp 
    370                 375                 380                 


Trp Gln Asp Leu Phe Arg Ile Val Phe Arg Ile Phe Asp Asn Met Lys 
385                 390                 395                 400 


Leu Pro Glu Gln Gln Xaa Glu Lys Ala Glu Trp Met Xaa Xaa Xaa Cys 
                405                 410                 415     


Asn His Ala Leu Tyr Ala Ile Cys Asp Val Phe Xaa Gln Tyr Leu Glu 
            420                 425                 430         


Val Leu Ser Asp Val Leu Leu Asp Asp Ile Phe Ala Gln Leu Tyr Trp 
        435                 440                 445             


Cys Val Gln Gln Asp Asn Glu Gln Leu Ala Arg Ser Gly Xaa Asn Cys 
    450                 455                 460                 


Leu Glu Asn Val Val Ile Leu Asn Gly Glu Lys Phe Xaa Leu Glu Ile 
465                 470                 475                 480 


Trp Asp Lys Xaa Cys Asn Cys Xaa Leu Asp Ile Phe Lys Xaa Xaa Ile 
                485                 490                 495     


Pro His Ala Leu Leu Xaa Trp Arg Pro Asn Ser Gly Glu Xaa Ala Pro 
            500                 505                 510         


Pro Pro Pro Ser Pro Val Ser Glu Lys Pro Leu Asp Xaa Ile Ser Gln 
        515                 520                 525             


Lys Ser Val Asp Ile His Asp Ser Ile Gln Pro Arg Ser Val Asp Asn 
    530                 535                 540                 


Arg Pro Gln Ala Pro Leu Val Ser Ala Ser Ala Val Asn Glu Glu Val 
545                 550                 555                 560 


Ser Lys Ile Lys Ser Xaa Ala Lys Phe Pro Glu Gln Lys Leu Phe Ala 
                565                 570                 575     


Ala Leu Leu Ile Lys Cys Val Val Gln Leu Glu Leu Ile Gln Xaa Ile 
            580                 585                 590         


Asp Asn Ile Val Phe Phe Pro Ala Xaa Ser Lys Lys Glu Asp Ala Glu 
        595                 600                 605             


Asn Leu Ala Ala Ala Gln Arg Asp Ala Val Asp Phe Asp Val Arg Val 
    610                 615                 620                 


Asp Xaa Gln Asp Gln Gly Met Tyr Arg Phe Leu Xaa Ser Gln Gln Leu 
625                 630                 635                 640 


Phe Lys Leu Leu Asp Cys Leu Leu Glu Ser His Arg Phe Ala Lys Ala 
                645                 650                 655     


Phe Asn Ser Asn Asn Glu Gln Arg Xaa Ala Leu Trp Lys Ala Gly Phe 
            660                 665                 670         


Lys Gly Lys Ser Lys Pro Asn Leu Leu Lys Gln Glu Xaa Ser Ser Leu 
        675                 680                 685             


Ala Cys Gly Leu Arg Ile Leu Phe Arg Met Tyr Met Asp Glu Ser Arg 
    690                 695                 700                 


Val Ser Ala Trp Glu Glu Val Gln Gln Arg Leu Leu Asn Val Cys Ser 
705                 710                 715                 720 


Glu Ala Leu Ser Tyr Phe Leu Xaa Leu Xaa Ser Glu Ser His Arg Glu 
                725                 730                 735     


Ala Trp Xaa Asn Leu Leu Leu Leu Phe Leu Xaa Lys Val Leu Lys Ile 
            740                 745                 750         


Ser Asp Asn Arg Val Ser Met Arg Leu Arg Ile Gln Pro His Ile Ser 
        755                 760                 765             


Ser Pro Ile Arg Ile Gly Met Arg Gly Pro Arg Ala Ala Val Gln Glu 
    770                 775                 780                 


Leu Ser Glu Met Asn Gln Ala Val Pro Arg Leu His Cys Cys Leu Cys 
785                 790                 795                 800 


Lys Ala Xaa Ser Gly Leu Ala Val Ser Ser Ser Val Leu Ala Phe Leu 
                805                 810                 815     


Pro Pro Tyr Pro Ala Leu Phe Xaa Asn 
            820                 825 


<210> 2691
<211> 1279
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1246)..(1246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1248)..(1248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1278)..(1278)
<223> Selenocysteine

<400> 2691
Xaa Ile Glu Val Phe Phe Lys Glu Ile Phe Leu Tyr Ile Leu Glu Xaa 
1               5                   10                  15      


Ser Xaa Ser Ser Phe Asp His Lys Trp Met Val Ile Gln Xaa Leu Xaa 
            20                  25                  30          


Arg Ile Cys Ala Asp Ala Gln Ser Val Val Asp Ile Tyr Val Asn Tyr 
        35                  40                  45              


Asp Cys Asp Leu Asn Ala Ala Asn Ile Phe Glu Arg Leu Val Asn Asp 
    50                  55                  60                  


Leu Ser Lys Ile Ala Gln Gly Arg Gly Ser Gln Glu Leu Gly Met Ser 
65                  70                  75                  80  


Asn Val Gln Glu Leu Ser Leu Arg Lys Lys Gly Leu Glu Cys Leu Val 
                85                  90                  95      


Ser Ile Leu Lys Cys Met Val Glu Trp Ser Lys Asp Gln Tyr Val Asn 
            100                 105                 110         


Pro Asn Ser Gln Xaa Xaa Leu Gly Gln Glu Lys Pro Ser Glu Gln Glu 
        115                 120                 125             


Met Ser Glu Ile Lys His Pro Glu Xaa Ile Asn Arg Tyr Gly Ser Leu 
    130                 135                 140                 


Asn Ser Leu Glu Ser Xaa Ser Ser Ser Gly Ile Gly Ser Tyr Ser Xaa 
145                 150                 155                 160 


Gln Met Ser Gly Xaa Asp Asn Pro Glu Gln Phe Glu Val Leu Lys Gln 
                165                 170                 175     


Gln Lys Glu Ile Ile Glu Gln Gly Ile Asp Leu Phe Asn Lys Lys Pro 
            180                 185                 190         


Lys Arg Gly Ile Gln Tyr Leu Gln Glu Gln Gly Met Leu Gly Xaa Xaa 
        195                 200                 205             


Pro Glu Asp Ile Ala Gln Phe Leu His Gln Glu Glu Arg Leu Asp Ser 
    210                 215                 220                 


Xaa Gln Val Gly Glu Phe Leu Gly Asp Asn Asp Lys Phe Asn Lys Glu 
225                 230                 235                 240 


Val Met Tyr Ala Tyr Val Asp Gln His Asp Phe Ser Gly Lys Asp Phe 
                245                 250                 255     


Val Ser Ala Leu Arg Met Phe Leu Glu Gly Phe Arg Leu Pro Gly Glu 
            260                 265                 270         


Ala Gln Lys Ile Asp Arg Leu Met Glu Lys Phe Ala Ala Arg Tyr Leu 
        275                 280                 285             


Glu Cys Asn Gln Gly Gln Xaa Leu Phe Ala Ser Ala Asp Xaa Ala Tyr 
    290                 295                 300                 


Val Leu Ala Tyr Ser Ile Ile Met Leu Xaa Xaa Asp Leu His Ser Pro 
305                 310                 315                 320 


Gln Val Lys Asn Lys Met Xaa Lys Glu Gln Tyr Ile Lys Met Asn Arg 
                325                 330                 335     


Gly Ile Asn Asp Ser Lys Asp Leu Pro Glu Glu Tyr Leu Ser Ala Ile 
            340                 345                 350         


Tyr Asn Glu Ile Ala Gly Lys Lys Ile Ser Met Lys Glu Xaa Lys Glu 
        355                 360                 365             


Leu Xaa Ile Pro Xaa Lys Ser Ser Lys Gln Asn Val Ala Ser Glu Lys 
    370                 375                 380                 


Gln Arg Arg Leu Leu Tyr Asn Leu Glu Met Glu Gln Met Ala Lys Xaa 
385                 390                 395                 400 


Ala Lys Ala Leu Met Glu Ala Val Ser His Val Gln Ala Pro Phe Xaa 
                405                 410                 415     


Ser Ala Xaa His Leu Glu His Val Arg Pro Met Phe Lys Leu Ala Trp 
            420                 425                 430         


Xaa Pro Phe Leu Ala Ala Phe Ser Val Gly Leu Gln Asp Cys Asp Asp 
        435                 440                 445             


Xaa Glu Val Ala Ser Leu Cys Leu Glu Gly Ile Arg Cys Ala Ile Arg 
    450                 455                 460                 


Ile Ala Cys Ile Phe Ser Ile Gln Leu Glu Arg Asp Ala Tyr Val Gln 
465                 470                 475                 480 


Ala Leu Ala Arg Phe Xaa Leu Leu Xaa Val Ser Ser Gly Ile Xaa Glu 
                485                 490                 495     


Met Lys Gln Lys Asn Ile Asp Xaa Ile Lys Xaa Leu Ile Xaa Val Ala 
            500                 505                 510         


His Xaa Asp Gly Asn Tyr Leu Gly Asn Ser Trp His Glu Ile Leu Lys 
        515                 520                 525             


Cys Ile Ser Gln Leu Glu Leu Ala Gln Leu Ile Gly Xaa Gly Val Lys 
    530                 535                 540                 


Pro Arg Tyr Ile Ser Gly Xaa Val Arg Gly Arg Glu Gly Ser Leu Xaa 
545                 550                 555                 560 


Gly Xaa Lys Asp Gln Ala Pro Asp Glu Phe Val Gly Leu Gly Leu Val 
                565                 570                 575     


Gly Gly Asn Val Asp Trp Lys Gln Ile Ala Ser Ile Gln Glu Ser Ile 
            580                 585                 590         


Gly Glu Xaa Ser Ser Gln Ser Val Val Val Ala Val Asp Arg Ile Phe 
        595                 600                 605             


Xaa Gly Ser Xaa Arg Leu Asp Gly Asn Ala Ile Val Asp Phe Val Arg 
    610                 615                 620                 


Trp Leu Cys Ala Val Ser Met Asp Glu Leu Leu Ser Xaa Xaa His Pro 
625                 630                 635                 640 


Arg Met Phe Ser Leu Gln Lys Ile Val Glu Ile Ser Tyr Tyr Asn Met 
                645                 650                 655     


Gly Arg Ile Arg Leu Gln Trp Ser Arg Ile Trp Glu Val Ile Gly Asp 
            660                 665                 670         


His Phe Asn Lys Val Gly Cys Asn Pro Asn Glu Asp Val Ala Ile Phe 
        675                 680                 685             


Ala Val Asp Ser Leu Arg Gln Leu Ser Met Lys Phe Leu Glu Lys Gly 
    690                 695                 700                 


Glu Leu Ala Asn Phe Arg Phe Gln Lys Asp Phe Leu Arg Pro Phe Glu 
705                 710                 715                 720 


His Ile Met Lys Arg Asn Arg Ser Pro Xaa Ile Arg Asp Met Val Val 
                725                 730                 735     


Arg Cys Ile Ala Gln Met Val Asn Ser Gln Ala Ala Asn Ile Arg Ser 
            740                 745                 750         


Gly Trp Lys Asn Ile Phe Ser Val Phe His Leu Ala Ala Ser Asp Gln 
        755                 760                 765             


Asp Glu Ser Ile Val Glu Leu Ala Phe Gln Xaa Xaa Gly His Ile Val 
    770                 775                 780                 


Xaa Leu Val Phe Glu Lys His Phe Pro Ala Xaa Ile Asp Ser Phe Gln 
785                 790                 795                 800 


Asp Ala Val Lys Cys Leu Ser Glu Phe Ala Cys Asn Ala Ala Phe Pro 
                805                 810                 815     


Asp Xaa Ser Met Glu Ala Ile Arg Leu Ile Arg His Cys Ala Lys Tyr 
            820                 825                 830         


Val Ser Asp Arg Pro Gln Ala Phe Lys Glu Tyr Xaa Ser Asp Asp Met 
        835                 840                 845             


Asn Val Ala Pro Glu Asp Arg Val Trp Val Arg Gly Trp Phe Pro Ile 
    850                 855                 860                 


Leu Phe Glu Leu Ser Cys Ile Ile Asn Arg Cys Lys Leu Asp Val Arg 
865                 870                 875                 880 


Xaa Arg Gly Leu Xaa Val Met Phe Glu Ile Met Lys Xaa Tyr Gly His 
                885                 890                 895     


Xaa Tyr Glu Lys His Trp Trp Gln Asp Leu Phe Arg Ile Val Phe Arg 
            900                 905                 910         


Ile Phe Asp Asn Met Lys Leu Pro Glu Gln Gln Xaa Glu Lys Ala Glu 
        915                 920                 925             


Trp Met Xaa Xaa Xaa Cys Asn His Ala Leu Tyr Ala Ile Cys Asp Val 
    930                 935                 940                 


Phe Xaa Gln Tyr Leu Glu Val Leu Ser Asp Val Leu Leu Asp Asp Ile 
945                 950                 955                 960 


Phe Ala Gln Leu Tyr Trp Cys Val Gln Gln Asp Asn Glu Gln Leu Ala 
                965                 970                 975     


Arg Ser Gly Xaa Asn Cys Leu Glu Asn Val Val Ile Leu Asn Gly Glu 
            980                 985                 990         


Lys Phe Xaa Leu Glu Ile Trp Asp  Lys Xaa Cys Asn Cys  Xaa Leu Asp 
        995                 1000                 1005             


Ile Phe  Lys Xaa Xaa Ile Pro  His Ala Leu Leu Xaa  Trp Arg Pro 
    1010                 1015                 1020             


Asn Ser  Gly Glu Xaa Ala Pro  Pro Pro Pro Ser Pro  Val Ser Glu 
    1025                 1030                 1035             


Lys Pro  Leu Asp Xaa Ile Ser  Gln Lys Ser Val Asp  Ile His Asp 
    1040                 1045                 1050             


Ser Ile  Gln Pro Arg Ser Val  Asp Asn Arg Pro Gln  Ala Pro Leu 
    1055                 1060                 1065             


Val Ser  Ala Ser Ala Val Asn  Glu Glu Val Ser Lys  Ile Lys Ser 
    1070                 1075                 1080             


Xaa Ala  Lys Phe Pro Glu Gln  Lys Leu Phe Ala Ala  Leu Leu Ile 
    1085                 1090                 1095             


Lys Cys  Val Val Gln Leu Glu  Leu Ile Gln Xaa Ile  Asp Asn Ile 
    1100                 1105                 1110             


Val Phe  Phe Pro Ala Xaa Ser  Lys Lys Glu Asp Ala  Glu Asn Leu 
    1115                 1120                 1125             


Ala Ala  Ala Gln Arg Asp Ala  Val Asp Phe Asp Val  Arg Val Asp 
    1130                 1135                 1140             


Xaa Gln  Asp Gln Gly Met Tyr  Arg Phe Leu Xaa Ser  Gln Gln Leu 
    1145                 1150                 1155             


Phe Lys  Leu Leu Asp Cys Leu  Leu Glu Ser His Arg  Phe Ala Lys 
    1160                 1165                 1170             


Ala Phe  Asn Ser Asn Asn Glu  Gln Arg Xaa Ala Leu  Trp Lys Ala 
    1175                 1180                 1185             


Gly Phe  Lys Gly Lys Ser Lys  Pro Asn Leu Leu Lys  Gln Glu Xaa 
    1190                 1195                 1200             


Ser Ser  Leu Ala Cys Gly Leu  Arg Ile Leu Phe Arg  Met Tyr Met 
    1205                 1210                 1215             


Asp Glu  Ser Arg Val Ser Ala  Trp Glu Glu Val Gln  Gln Arg Leu 
    1220                 1225                 1230             


Leu Asn  Val Cys Ser Glu Ala  Leu Ser Tyr Phe Leu  Xaa Leu Xaa 
    1235                 1240                 1245             


Ser Glu  Ser His Arg Glu Ala  Trp Xaa Asn Leu Leu  Leu Leu Phe 
    1250                 1255                 1260             


Leu Xaa  Lys Val Leu Lys Ile  Ser Asp Asn Arg Xaa  Lys Arg Xaa 
    1265                 1270                 1275             


Leu 
    


<210> 2692
<211> 192
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<400> 2692
Xaa Arg Leu Leu Leu Met Lys Lys Ser Ala Lys Leu Asn Leu Gln Gln 
1               5                   10                  15      


Leu Glu Leu Ile Gln Xaa Ile Asp Asn Ile Val Phe Phe Pro Ala Xaa 
            20                  25                  30          


Ser Lys Lys Glu Asp Ala Glu Asn Leu Ala Ala Ala Gln Arg Asp Ala 
        35                  40                  45              


Val Asp Phe Asp Val Arg Val Asp Xaa Gln Asp Gln Gly Met Tyr Arg 
    50                  55                  60                  


Phe Leu Xaa Ser Gln Gln Leu Phe Lys Leu Leu Asp Cys Leu Leu Glu 
65                  70                  75                  80  


Ser His Arg Phe Ala Lys Ala Phe Asn Ser Asn Asn Glu Gln Arg Xaa 
                85                  90                  95      


Ala Leu Trp Lys Ala Gly Phe Lys Gly Lys Ser Lys Pro Asn Leu Leu 
            100                 105                 110         


Lys Gln Glu Xaa Ser Ser Leu Ala Cys Gly Leu Arg Ile Leu Phe Arg 
        115                 120                 125             


Met Tyr Met Asp Glu Ser Arg Val Ser Ala Trp Glu Glu Val Gln Gln 
    130                 135                 140                 


Arg Leu Leu Asn Val Cys Ser Glu Ala Leu Ser Tyr Phe Leu Xaa Leu 
145                 150                 155                 160 


Xaa Ser Glu Ser His Arg Glu Ala Trp Xaa Asn Leu Leu Leu Leu Phe 
                165                 170                 175     


Leu Xaa Lys Val Leu Lys Ile Ser Asp Asn Arg Xaa Lys Arg Xaa Leu 
            180                 185                 190         


<210> 2693
<211> 1785
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1007)..(1007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1247)..(1248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1253)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1349)..(1349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1353)..(1353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1365)..(1365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1399)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1448)..(1448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1470)..(1470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1480)..(1481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1488)..(1488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1531)..(1531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1562)..(1562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1572)..(1572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1588)..(1588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1597)..(1597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1636)..(1636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1656)..(1656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1688)..(1688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1699)..(1699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1710)..(1710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1718)..(1718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1720)..(1720)
<223> Selenocysteine

<400> 2693
Met Gln Glu Ser Gln Xaa Lys Ser Met Phe Val Ser Arg Ala Leu Glu 
1               5                   10                  15      


Lys Ile Leu Ala Asp Lys Glu Val Lys Arg Pro Gln His Ser Gln Leu 
            20                  25                  30          


Arg Arg Ala Cys Gln Val Ala Leu Asp Glu Ile Lys Ala Glu Ile Glu 
        35                  40                  45              


Lys Gln Arg Leu Gly Xaa Ala Ala Pro Pro Lys Ala Asn Phe Ile Glu 
    50                  55                  60                  


Ala Asp Lys Tyr Phe Leu Pro Phe Glu Leu Ala Cys Gln Ser Lys Ser 
65                  70                  75                  80  


Pro Arg Val Val Ser Xaa Ser Leu Asp Cys Leu Gln Lys Leu Ile Ala 
                85                  90                  95      


Tyr Gly His Ile Xaa Gly Asn Ala Pro Asp Ser Gly Ala Pro Gly Lys 
            100                 105                 110         


Arg Leu Ile Asp Arg Ile Val Glu Xaa Ile Cys Ser Cys Phe Gln Gly 
        115                 120                 125             


Pro Gln Xaa Asp Glu Gly Val Gln Leu Gln Ile Ile Lys Ala Leu Leu 
    130                 135                 140                 


Xaa Ala Val Xaa Ser Pro His Ile Glu Ile His Glu Gly Xaa Ile Leu 
145                 150                 155                 160 


Gln Xaa Val Arg Xaa Cys Tyr Asn Ile Tyr Leu Ala Ser Lys Asn Leu 
                165                 170                 175     


Ile Asn Gln Xaa Xaa Ala Lys Ala Xaa Leu Xaa Gln Met Leu Asn Val 
            180                 185                 190         


Ile Phe Xaa Arg Met Glu Asn Gln Val Leu Gln Glu Ala Arg Glu Leu 
        195                 200                 205             


Glu Lys Pro Ile Gln Ser Lys Pro Gln Ser Pro Val Ile Gln Ala Ala 
    210                 215                 220                 


Ala Val Ser Pro Lys Phe Val Arg Leu Lys His Ser Gln Ala Gln Ser 
225                 230                 235                 240 


Lys Pro Xaa Xaa Pro Glu Lys Xaa Asp Leu Xaa Asn Gly Glu His Ala 
                245                 250                 255     


Arg Ser Asp Ser Gly Lys Val Ser Xaa Glu Asn Gly Asp Ala Pro Arg 
            260                 265                 270         


Glu Arg Gly Ser Ser Leu Ser Gly Xaa Asp Asp Gly Ala Gln Glu Val 
        275                 280                 285             


Val Lys Asp Ile Leu Glu Asp Val Val Xaa Ser Ala Ile Lys Glu Ala 
    290                 295                 300                 


Ala Glu Lys His Gly Leu Xaa Glu Pro Glu Arg Val Leu Gly Glu Leu 
305                 310                 315                 320 


Glu Cys Gln Glu Cys Ala Ile Pro Pro Gly Val Asp Glu Asn Ser Gln 
                325                 330                 335     


Xaa Asn Gly Ile Ala Asp Asp Arg Gln Ser Leu Ser Ser Ala Asp Asn 
            340                 345                 350         


Leu Glu Ser Asp Ala Gln Gly His Gln Val Ala Ala Arg Phe Ser His 
        355                 360                 365             


Val Leu Gln Lys Asp Ala Phe Leu Val Phe Arg Ser Leu Cys Lys Leu 
    370                 375                 380                 


Ser Met Lys Pro Leu Gly Glu Gly Pro Pro Asp Pro Lys Ser His Glu 
385                 390                 395                 400 


Leu Arg Ser Lys Val Val Ser Leu Gln Leu Leu Leu Ser Val Leu Gln 
                405                 410                 415     


Asn Ala Gly Pro Val Phe Arg Xaa His Glu Met Phe Ile Asn Ala Ile 
            420                 425                 430         


Lys Gln Tyr Leu Cys Val Ala Leu Ser Lys Asn Gly Val Ser Ser Val 
        435                 440                 445             


Pro Asp Val Phe Glu Leu Ser Leu Ala Ile Phe Leu Xaa Leu Leu Ser 
    450                 455                 460                 


Asn Phe Lys Met His Leu Lys Met Gln Ile Glu Val Phe Phe Lys Glu 
465                 470                 475                 480 


Ile Phe Leu Asn Ile Leu Glu Xaa Ser Xaa Ser Ser Phe Glu His Arg 
                485                 490                 495     


Trp Met Val Ile Gln Xaa Leu Xaa Arg Ile Cys Ala Asp Ala Gln Cys 
            500                 505                 510         


Val Val Asp Ile Tyr Val Asn Tyr Asp Cys Asp Leu Asn Ala Ala Asn 
        515                 520                 525             


Ile Phe Glu Arg Leu Val Asn Asp Leu Ser Lys Ile Ala Gln Gly Arg 
    530                 535                 540                 


Ser Gly His Glu Leu Gly Met Xaa Pro Leu Gln Glu Leu Ser Leu Arg 
545                 550                 555                 560 


Lys Lys Gly Leu Glu Cys Leu Val Ser Ile Leu Lys Cys Met Val Glu 
                565                 570                 575     


Trp Ser Lys Asp Leu Tyr Val Asn Pro Asn His Gln Xaa Ser Leu Gly 
            580                 585                 590         


Gln Glu Arg Leu Xaa Asp Gln Glu Ile Gly Asp Gly Lys Gly Leu Asp 
        595                 600                 605             


Met Ala Arg Arg Cys Ser Val Xaa Ser Met Glu Ser Xaa Val Ser Ser 
    610                 615                 620                 


Gly Xaa Gln Xaa Xaa Val Gln Asp Asp Pro Glu Gln Phe Glu Val Ile 
625                 630                 635                 640 


Lys Gln Gln Lys Glu Ile Ile Glu His Gly Ile Glu Leu Phe Asn Lys 
                645                 650                 655     


Lys Pro Lys Arg Gly Ile Gln Phe Leu Gln Glu Gln Gly Met Leu Gly 
            660                 665                 670         


Xaa Ser Val Glu Asp Ile Ala Gln Phe Leu His Gln Glu Glu Arg Leu 
        675                 680                 685             


Asp Ser Xaa Gln Val Gly Asp Phe Leu Gly Asp Ser Ala Arg Phe Asn 
    690                 695                 700                 


Lys Glu Val Met Tyr Ala Tyr Val Asp Gln Leu Asp Phe Cys Glu Lys 
705                 710                 715                 720 


Glu Phe Val Ser Ala Leu Arg Xaa Phe Leu Glu Gly Phe Arg Leu Pro 
                725                 730                 735     


Gly Glu Ala Gln Lys Ile Asp Arg Leu Met Glu Lys Phe Ala Ala Arg 
            740                 745                 750         


Tyr Ile Glu Cys Asn Gln Gly Gln Xaa Leu Phe Ala Ser Ala Asp Xaa 
        755                 760                 765             


Ala Tyr Val Leu Ala Tyr Ser Ile Ile Met Leu Xaa Xaa Asp Leu His 
    770                 775                 780                 


Ser Pro Gln Val Lys Asn Lys Met Xaa Lys Glu Gln Tyr Ile Lys Met 
785                 790                 795                 800 


Asn Arg Gly Ile Asn Asp Ser Lys Asp Leu Pro Glu Glu Tyr Leu Ser 
                805                 810                 815     


Ser Ile Tyr Glu Glu Ile Glu Gly Lys Lys Ile Ala Met Lys Glu Xaa 
            820                 825                 830         


Lys Glu Leu Xaa Ile Ala Xaa Lys Ser Xaa Lys Gln Asn Val Ala Ser 
        835                 840                 845             


Glu Lys Gln Arg Arg Leu Leu Tyr Asn Leu Glu Met Glu Gln Met Ala 
    850                 855                 860                 


Lys Xaa Ala Lys Ala Leu Met Glu Ala Val Ser His Ala Lys Ala Pro 
865                 870                 875                 880 


Phe Xaa Ser Ala Xaa His Leu Asp His Val Arg Pro Met Phe Lys Leu 
                885                 890                 895     


Val Trp Xaa Pro Leu Leu Ala Ala Tyr Ser Ile Gly Leu Gln Asn Cys 
            900                 905                 910         


Asp Asp Xaa Glu Val Ala Ser Leu Cys Leu Glu Gly Ile Arg Cys Ala 
        915                 920                 925             


Ile Arg Ile Ala Cys Ile Phe Gly Met Gln Leu Glu Arg Asp Ala Tyr 
    930                 935                 940                 


Val Gln Ala Leu Ala Arg Phe Ser Leu Leu Xaa Ala Ser Ser Ser Ile 
945                 950                 955                 960 


Xaa Glu Met Lys Gln Lys Asn Ile Asp Xaa Ile Lys Xaa Leu Ile Xaa 
                965                 970                 975     


Val Ala His Xaa Asp Gly Asn Tyr Leu Gly Asn Ser Trp His Glu Ile 
            980                 985                 990         


Leu Lys Cys Ile Ser Gln Leu Glu  Leu Ala Gln Leu Ile  Gly Xaa Gly 
        995                 1000                 1005             


Val Lys  Xaa Arg Tyr Leu Ser  Gly Ser Gly Arg Glu  Arg Glu Gly 
    1010                 1015                 1020             


Ser Leu  Lys Gly His Xaa Leu  Ala Gly Glu Glu Phe  Met Gly Leu 
    1025                 1030                 1035             


Gly Leu  Gly Asn Leu Val Ser  Gly Gly Val Asp Lys  Arg Gln Met 
    1040                 1045                 1050             


Ala Ser  Phe Gln Glu Ser Val  Gly Glu Xaa Ser Ser  Gln Ser Val 
    1055                 1060                 1065             


Val Val  Ala Val Asp Arg Ile  Phe Xaa Gly Ser Xaa  Arg Leu Asp 
    1070                 1075                 1080             


Gly Asn  Ala Ile Val Asp Phe  Val Arg Trp Leu Cys  Ala Val Ser 
    1085                 1090                 1095             


Met Asp  Glu Leu Ala Ser Pro  His His Pro Arg Met  Phe Ser Leu 
    1100                 1105                 1110             


Gln Lys  Ile Val Glu Ile Ser  Tyr Tyr Asn Met Asn  Arg Ile Arg 
    1115                 1120                 1125             


Leu Gln  Trp Ser Arg Ile Trp  His Val Ile Gly Asp  His Phe Asn 
    1130                 1135                 1140             


Lys Val  Gly Cys Asn Pro Asn  Glu Asp Val Ala Ile  Phe Ala Val 
    1145                 1150                 1155             


Asp Ser  Leu Arg Gln Leu Ser  Met Lys Phe Leu Glu  Lys Gly Glu 
    1160                 1165                 1170             


Leu Ala  Asn Phe Arg Phe Gln  Lys Asp Phe Leu Arg  Pro Phe Glu 
    1175                 1180                 1185             


His Ile  Met Lys Lys Asn Arg  Ser Pro Xaa Ile Arg  Asp Met Ala 
    1190                 1195                 1200             


Ile Arg  Cys Ile Ala Gln Met  Val Asn Ser Gln Ala  Ala Asn Ile 
    1205                 1210                 1215             


Arg Ser  Gly Trp Lys Asn Ile  Phe Ala Val Phe His  Gln Ala Ala 
    1220                 1225                 1230             


Ser Asp  His Asp Gly Asn Ile  Val Glu Leu Ala Phe  Gln Xaa Xaa 
    1235                 1240                 1245             


Cys His  Ile Val Xaa Xaa Ile  Phe Gln His His Phe  Pro Ala Ala 
    1250                 1255                 1260             


Ile Asp  Ser Phe Gln Asp Ala  Val Lys Cys Leu Ser  Glu Phe Ala 
    1265                 1270                 1275             


Cys Asn  Ala Ala Phe Pro Asp  Xaa Ser Met Glu Ala  Ile Arg Leu 
    1280                 1285                 1290             


Ile Arg  Phe Cys Gly Lys Tyr  Val Ser Glu Arg Pro  Arg Val Leu 
    1295                 1300                 1305             


Gln Glu  Tyr Xaa Ser Asp Asp  Met Asn Val Ala Pro  Gly Asp Arg 
    1310                 1315                 1320             


Val Trp  Val Arg Gly Trp Phe  Pro Ile Leu Phe Glu  Leu Ser Cys 
    1325                 1330                 1335             


Ile Ile  Asn Arg Cys Lys Leu  Asp Val Arg Xaa Arg  Gly Leu Xaa 
    1340                 1345                 1350             


Val Met  Phe Glu Ile Met Lys  Ser Tyr Gly His Xaa  Phe Glu Lys 
    1355                 1360                 1365             


His Trp  Trp Gln Asp Leu Phe  Arg Ile Val Phe Arg  Ile Phe Asp 
    1370                 1375                 1380             


Asn Met  Lys Leu Pro Glu Gln  Leu Ser Glu Lys Ser  Glu Trp Met 
    1385                 1390                 1395             


Xaa Xaa  Xaa Cys Asn His Ala  Leu Tyr Ala Ile Cys  Asp Val Phe 
    1400                 1405                 1410             


Xaa Gln  Phe Tyr Glu Ala Leu  Asn Glu Val Leu Leu  Ser Asp Val 
    1415                 1420                 1425             


Phe Ala  Gln Leu Gln Trp Cys  Val Lys Gln Asp Asn  Glu Gln Leu 
    1430                 1435                 1440             


Ala Arg  Ser Gly Xaa Asn Cys  Leu Glu Asn Leu Val  Ile Ser Asn 
    1445                 1450                 1455             


Gly Glu  Lys Phe Ser Pro Glu  Val Trp Asp Glu Xaa  Cys Asn Cys 
    1460                 1465                 1470             


Met Leu  Asp Ile Phe Lys Xaa  Xaa Ile Pro His Val  Leu Leu Xaa 
    1475                 1480                 1485             


Trp Arg  Pro Val Gly Met Glu  Glu Asp Ser Ser Glu  Lys His Leu 
    1490                 1495                 1500             


Asp Val  Asp Leu Asp Arg Gln  Ser Leu Ser Ser Ile  Asp Lys Asn 
    1505                 1510                 1515             


Pro Ser  Glu Arg Gly Gln Ser  Gln Leu Ser Asn Pro  Xaa Asp Asp 
    1520                 1525                 1530             


Ser Trp  Lys Gly Arg Pro Tyr  Ala Asn Gln Lys Leu  Phe Ala Ser 
    1535                 1540                 1545             


Leu Leu  Ile Lys Cys Val Val  Gln Leu Glu Leu Ile  Gln Xaa Ile 
    1550                 1555                 1560             


Asp Asn  Ile Val Phe Tyr Pro  Ala Xaa Ser Lys Lys  Glu Asp Ala 
    1565                 1570                 1575             


Glu His  Met Val Ala Ala Gln  Gln Asp Xaa Leu Asp  Ala Asp Ile 
    1580                 1585                 1590             


His Ile  Glu Xaa Glu Asp Gln  Gly Met Tyr Lys Tyr  Met Ser Ser 
    1595                 1600                 1605             


Gln His  Leu Phe Lys Leu Leu  Asp Cys Leu Gln Glu  Ser His Ser 
    1610                 1615                 1620             


Phe Ser  Lys Ala Phe Asn Ser  Asn Tyr Glu Gln Arg  Xaa Val Leu 
    1625                 1630                 1635             


Trp Arg  Ala Gly Phe Lys Gly  Lys Ser Lys Pro Asn  Leu Leu Lys 
    1640                 1645                 1650             


Gln Glu  Xaa Ser Ser Leu Ala  Cys Cys Leu Arg Ile  Leu Phe Arg 
    1655                 1660                 1665             


Met Tyr  Val Asp Glu Asn Arg  Arg Asp Ser Trp Glu  Glu Ile Gln 
    1670                 1675                 1680             


Gln Arg  Leu Leu Xaa Val Cys  Ser Glu Ala Leu Ala  Tyr Phe Ile 
    1685                 1690                 1695             


Xaa Val  Asn Ser Glu Ser His  Arg Glu Ala Trp Xaa  Ser Leu Leu 
    1700                 1705                 1710             


Leu Leu  Leu Leu Xaa Lys Xaa  Leu Lys Ile Asn Asp  Glu Lys Phe 
    1715                 1720                 1725             


Lys Ala  His Ala Ser Met Tyr  Tyr Pro Tyr Leu Cys  Glu Ile Met 
    1730                 1735                 1740             


Gln Phe  Asp Leu Ile Pro Glu  Leu Arg Ala Val Leu  Arg Lys Phe 
    1745                 1750                 1755             


Phe Leu  Arg Ile Gly Val Val  Tyr Lys Ile Trp Ile  Pro Glu Glu 
    1760                 1765                 1770             


Pro Ser  Gln Val Pro Ala Ala  Leu Ser Pro Val Trp  
    1775                 1780                 1785 


<210> 2694
<211> 2177
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1173)..(1173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1238)..(1238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1448)..(1448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1462)..(1462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1476)..(1476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1488)..(1488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1490)..(1490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1560)..(1560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1577)..(1577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1579)..(1579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1600)..(1600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1618)..(1618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1673)..(1673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1679)..(1679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1705)..(1705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1747)..(1747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1780)..(1780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1786)..(1786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1827)..(1827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1831)..(1831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1833)..(1833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1849)..(1849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1866)..(1866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1949)..(1949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1952)..(1952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1960)..(1960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2015)..(2015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2021)..(2021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2027)..(2027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2098)..(2098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2117)..(2117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2122)..(2122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2134)..(2134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2136)..(2136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2150)..(2150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2154)..(2154)
<223> Selenocysteine

<400> 2694
Met Glu Glu Ile Leu Arg Lys Leu Gln Lys Glu Ala Ser Gly Ser Lys 
1               5                   10                  15      


Tyr Lys Ala Ile Lys Glu Ser Cys Xaa Trp Ala Leu Glu Xaa Leu Gly 
            20                  25                  30          


Gly Leu Asp Xaa Ile Val Lys Ile Pro Pro His Val Leu Arg Glu Lys 
        35                  40                  45              


Cys Leu Leu Pro Leu Gln Leu Ala Leu Glu Ser Lys Asn Val Lys Leu 
    50                  55                  60                  


Ala Gln His Ala Leu Ala Gly Met Gln Lys Leu Leu Ser Glu Glu Arg 
65                  70                  75                  80  


Phe Val Ser Met Glu Xaa Asp Ser Asp Glu Lys Gln Leu Leu Asn Gln 
                85                  90                  95      


Ile Leu Asn Ala Val Lys Val Xaa Pro Ser Leu Asn Glu Asp Leu Gln 
            100                 105                 110         


Val Glu Val Met Lys Val Leu Leu Cys Ile Xaa Tyr Xaa Pro Xaa Phe 
        115                 120                 125             


Asp Leu Asn Gly Ser Ala Val Leu Lys Ile Ala Glu Val Cys Ile Glu 
    130                 135                 140                 


Xaa Tyr Ile Ser Ser Cys His Gln Arg Ser Ile Asn Xaa Ala Val Arg 
145                 150                 155                 160 


Ala Xaa Leu Ser Gln Met Leu Ser Asp Leu Xaa Leu Gln Leu Arg Gln 
                165                 170                 175     


Arg Gln Glu Asn Xaa Ile Ile Glu Asn Pro Asp Val Pro Gln Asp Phe 
            180                 185                 190         


Gly Asn Gln Gly Ser Xaa Val Glu Ser Leu Cys Asp Asp Val Val Ser 
        195                 200                 205             


Val Leu Xaa Val Leu Cys Glu Lys Leu Gln Ala Ala Ile Asn Asp Ser 
    210                 215                 220                 


Gln Gln Leu Gln Leu Leu Tyr Leu Glu Cys Ile Leu Ser Val Leu Ser 
225                 230                 235                 240 


Ser Ser Ser Ser Ser Met His Leu His Arg Arg Phe Xaa Asp Leu Ile 
                245                 250                 255     


Trp Lys Asn Leu Cys Pro Ala Leu Ile Val Ile Leu Gly Asn Pro Ile 
            260                 265                 270         


His Asp Lys Xaa Ile Xaa Ser Ala His Xaa Ser Ser Xaa Ser Xaa Ser 
        275                 280                 285             


Leu Glu Ser Asp Ser Ala Ser Pro Gly Val Ser Asp His Gly Arg Gly 
    290                 295                 300                 


Ser Gly Cys Ser Cys Xaa Ala Pro Ala Leu Ser Gly Pro Val Ala Arg 
305                 310                 315                 320 


Xaa Ile Tyr Tyr Ile Ala Ala Glu Leu Val Arg Leu Val Gly Ser Val 
                325                 330                 335     


Asp Ser Met Lys Pro Val Leu Gln Ser Leu Tyr His Arg Val Leu Leu 
            340                 345                 350         


Tyr Pro Pro Pro Gln His Arg Val Glu Ala Ile Lys Ile Met Lys Glu 
        355                 360                 365             


Ile Leu Gly Ser Pro Gln Arg Leu Cys Asp Leu Ala Gly Pro Ser Ser 
    370                 375                 380                 


Xaa Glu Ser Glu Ser Arg Lys Arg Ser Ile Ser Lys Arg Lys Ser His 
385                 390                 395                 400 


Leu Asp Leu Leu Lys Leu Ile Met Asp Gly Met Xaa Glu Ala Cys Ile 
                405                 410                 415     


Lys Gly Gly Ile Glu Ala Cys Tyr Ala Ala Val Ser Cys Val Cys Xaa 
            420                 425                 430         


Leu Leu Gly Ala Leu Asp Glu Leu Ser Gln Gly Lys Gly Leu Ser Glu 
        435                 440                 445             


Gly Gln Val Gln Leu Leu Leu Leu Arg Leu Glu Glu Leu Lys Asp Gly 
    450                 455                 460                 


Ala Glu Trp Ser Arg Asp Ser Met Glu Ile Asn Glu Ala Asp Phe Arg 
465                 470                 475                 480 


Trp Gln Arg Arg Val Leu Ser Ser Glu His Xaa Pro Trp Glu Ser Gly 
                485                 490                 495     


Asn Glu Arg Ser Leu Asp Ile Ser Ile Ser Val Xaa Xaa Asp Xaa Gly 
            500                 505                 510         


Gln Xaa Xaa Leu Glu Gly Glu Leu Gly Gln Xaa Xaa Pro Glu Asp His 
        515                 520                 525             


Ser Gly Asn His Lys Asn Ser Leu Lys Ser Pro Ala Ile Pro Glu Gly 
    530                 535                 540                 


Lys Glu Xaa Leu Ser Lys Val Leu Glu Xaa Glu Ala Val Asp Gln Pro 
545                 550                 555                 560 


Asp Val Val Gln Arg Ser His Xaa Val Pro Tyr Pro Asp Ile Xaa Asn 
                565                 570                 575     


Phe Leu Ser Val Asp Cys Arg Xaa Arg Ser Tyr Gly Ser Arg Tyr Ser 
            580                 585                 590         


Glu Ser Asn Phe Ser Val Asp Asp Gln Asp Leu Ser Arg Xaa Glu Phe 
        595                 600                 605             


Asp Ser Cys Asp Gln Tyr Ser Met Ala Ala Glu Lys Asp Ser Gly Arg 
    610                 615                 620                 


Ser Asp Val Ser Asp Ile Gly Ser Asp Asn Cys Ser Leu Ala Asp Glu 
625                 630                 635                 640 


Glu Gln Xaa Pro Arg Asp Cys Leu Gly His Arg Ser Leu Arg Xaa Ala 
                645                 650                 655     


Ala Leu Ser Leu Lys Leu Leu Lys Asn Gln Glu Ala Asp Gln His Ser 
            660                 665                 670         


Ala Arg Leu Phe Ile Gln Ser Leu Glu Gly Leu Leu Pro Arg Leu Leu 
        675                 680                 685             


Ser Leu Ser Asn Val Glu Glu Val Asp Xaa Ala Leu Gln Asn Phe Ala 
    690                 695                 700                 


Ser Xaa Phe Cys Ser Gly Met Met His Ser Pro Gly Phe Asp Gly Asn 
705                 710                 715                 720 


Ser Ser Leu Ser Phe Gln Met Leu Met Asn Ala Asp Ser Leu Tyr Xaa 
                725                 730                 735     


Ala Ala His Cys Ala Leu Leu Leu Asn Leu Lys Leu Ser His Gly Asp 
            740                 745                 750         


Tyr Tyr Arg Lys Arg Pro Xaa Leu Ala Pro Gly Val Met Lys Asp Phe 
        755                 760                 765             


Met Lys Gln Val Gln Xaa Ser Gly Val Leu Met Val Phe Ser Gln Ala 
    770                 775                 780                 


Trp Ile Glu Glu Leu Tyr His Gln Val Leu Asp Arg Asn Met Leu Gly 
785                 790                 795                 800 


Glu Ala Gly Tyr Trp Gly Ser Pro Glu Asp Asn Ser Leu Pro Leu Ile 
                805                 810                 815     


Xaa Met Leu Xaa Asp Ile Asp Gly Leu Glu Ser Ser Ala Ile Gly Gly 
            820                 825                 830         


Gln Leu Met Ala Ser Ala Ala Xaa Glu Ser Pro Phe Ala Gln Ser Arg 
        835                 840                 845             


Arg Ile Asp Asp Ser Xaa Val Ala Gly Val Ala Phe Ala Arg Tyr Ile 
    850                 855                 860                 


Leu Val Gly Cys Trp Lys Asn Leu Ile Asp Xaa Leu Ser Xaa Pro Leu 
865                 870                 875                 880 


Xaa Gly Arg Met Ala Gly Ser Ser Lys Gly Leu Ala Phe Ile Leu Gly 
                885                 890                 895     


Ala Glu Gly Ile Lys Glu Gln Asn Gln Lys Glu Arg Asp Ala Ile Cys 
            900                 905                 910         


Met Ser Leu Asp Gly Leu Arg Lys Ala Ala Arg Leu Ser Cys Ala Leu 
        915                 920                 925             


Gly Val Ala Ala Asn Cys Ala Ser Ala Leu Ala Gln Met Ala Ala Ala 
    930                 935                 940                 


Ser Cys Val Gln Glu Glu Lys Glu Glu Arg Glu Ala Gln Glu Pro Ser 
945                 950                 955                 960 


Asp Ala Ile Xaa Gln Val Lys Leu Lys Val Glu Gln Lys Leu Glu Gln 
                965                 970                 975     


Ile Gly Lys Val Gln Gly Val Trp Leu His Xaa Ala His Val Leu Cys 
            980                 985                 990         


Met Glu Ala Ile Leu Ser Val Gly  Leu Glu Met Gly Ser  His Asn Pro 
        995                 1000                 1005             


Asp Cys  Trp Pro His Val Phe  Arg Val Cys Glu Tyr  Val Gly Xaa 
    1010                 1015                 1020             


Leu Glu  His Asn His Phe Ser  Asp Gly Ala Ser Gln  Pro Pro Leu 
    1025                 1030                 1035             


Xaa Ile  Ser Gln Pro Gln Lys  Ala Xaa Gly Ser Ala  Gly Leu Leu 
    1040                 1045                 1050             


Gly Asp  Pro Glu Cys Glu Gly  Ser Pro Pro Glu His  Ser Pro Glu 
    1055                 1060                 1065             


Gln Gly  Arg Ser Leu Ser Xaa  Ala Pro Val Val Gln  Pro Leu Ser 
    1070                 1075                 1080             


Ile Gln  Asp Leu Val Arg Glu  Gly Ser Arg Gly Arg  Ala Ser Asp 
    1085                 1090                 1095             


Phe Arg  Gly Gly Ser Leu Met  Ser Gly Ser Ser Ala  Ala Lys Val 
    1100                 1105                 1110             


Val Leu  Xaa Leu Ser Xaa Gln  Ala Asp Arg Leu Phe  Glu Asp Ala 
    1115                 1120                 1125             


Xaa Asp  Lys Leu Asn Leu Met  Ala Leu Gly Gly Phe  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Lys  Lys Ala Ser Gln Ser  Gln Leu Phe His Ser  Val Xaa Asp 
    1145                 1150                 1155             


Xaa Val  Asp Tyr Ser Leu Ala  Met Pro Gly Glu Val  Lys Ser Xaa 
    1160                 1165                 1170             


Gln Asp  Arg Lys Ser Ala Leu  His Leu Phe Arg Leu  Gly Asn Ala 
    1175                 1180                 1185             


Met Leu  Arg Ile Val Arg Ser  Lys Ala Arg Pro Leu  Leu His Val 
    1190                 1195                 1200             


Met Arg  Cys Trp Ser Leu Val  Ala Pro His Leu Val  Glu Ala Ala 
    1205                 1210                 1215             


Cys His  Lys Glu Arg His Val  Ser Gln Lys Ala Val  Ser Phe Ile 
    1220                 1225                 1230             


His Asp  Ile Leu Xaa Glu Val  Leu Xaa Asp Trp Asn  Glu Pro Pro 
    1235                 1240                 1245             


His Phe  His Phe Asn Glu Ala  Leu Phe Arg Pro Phe  Glu Arg Ile 
    1250                 1255                 1260             


Met Gln  Leu Glu Leu Cys Asp  Glu Asp Val Gln Asp  Gln Val Val 
    1265                 1270                 1275             


Xaa Ser  Ile Gly Glu Leu Val  Glu Val Cys Ser Xaa  Gln Ile Gln 
    1280                 1285                 1290             


Ser Gly  Trp Arg Pro Leu Phe  Ser Ala Leu Glu Xaa  Val His Gly 
    1295                 1300                 1305             


Gly Asn  Lys Ser Glu Met Lys  Glu Tyr Leu Val Gly  Asp Tyr Ser 
    1310                 1315                 1320             


Met Gly  Lys Gly Gln Ala Pro  Val Phe Asp Val Phe  Glu Ala Phe 
    1325                 1330                 1335             


Leu Asn  Xaa Asp Asn Ile Gln  Val Phe Ala Asn Ala  Ala Xaa Ser 
    1340                 1345                 1350             


Tyr Ile  Met Cys Leu Met Lys  Phe Val Lys Gly Leu  Gly Glu Val 
    1355                 1360                 1365             


Asp Cys  Lys Glu Ile Gly Asp  Cys Ala Pro Ala Pro  Gly Ala Pro 
    1370                 1375                 1380             


Ser Xaa  Asp Leu Cys Leu Pro  Ala Leu Asp Tyr Leu  Arg Arg Cys 
    1385                 1390                 1395             


Ser Gln  Leu Leu Ala Lys Ile  Tyr Lys Met Pro Leu  Lys Pro Ile 
    1400                 1405                 1410             


Phe Leu  Ser Gly Arg Leu Ala  Gly Leu Pro Arg Arg  Leu Gln Glu 
    1415                 1420                 1425             


Gln Ser  Ala Ser Ser Glu Asp  Gly Ile Glu Ser Val  Leu Ser Asp 
    1430                 1435                 1440             


Phe Asp  Asp Asp Xaa Gly Leu  Ile Glu Val Trp Ile  Ile Leu Leu 
    1445                 1450                 1455             


Glu Gln  Leu Xaa Ala Ala Val  Ser Asn Cys Pro Arg  Gln His Gln 
    1460                 1465                 1470             


Pro Pro  Xaa Leu Asp Leu Leu  Phe Glu Leu Leu Arg  Asp Val Xaa 
    1475                 1480                 1485             


Lys Xaa  Pro Gly Pro Gly Phe  Gly Ile Tyr Ala Val  Val His Leu 
    1490                 1495                 1500             


Leu Leu  Pro Val Met Ser Val  Trp Leu Arg Arg Ser  His Lys Asp 
    1505                 1510                 1515             


His Ser  Tyr Trp Asp Met Ala  Ser Ala Asn Phe Lys  His Ala Ile 
    1520                 1525                 1530             


Gly Leu  Ser Cys Glu Leu Val  Val Glu His Ile Gln  Ser Phe Leu 
    1535                 1540                 1545             


His Ser  Asp Ile Arg Tyr Glu  Ser Met Ile Asn Xaa  Met Leu Lys 
    1550                 1555                 1560             


Asp Leu  Phe Glu Leu Leu Val  Ala Cys Val Ala Lys  Pro Xaa Glu 
    1565                 1570                 1575             


Xaa Ile  Ser Arg Val Gly Cys  Ser Cys Ile Arg Tyr  Val Leu Val 
    1580                 1585                 1590             


Xaa Ala  Gly Pro Val Phe Xaa  Glu Glu Met Trp Arg  Leu Ala Cys 
    1595                 1600                 1605             


Cys Ala  Leu Gln Asp Ala Phe  Ser Ala Xaa Leu Lys  Pro Val Lys 
    1610                 1615                 1620             


Asp Leu  Leu Gly Cys Phe His  Ser Gly Xaa Glu Ser  Phe Ser Gly 
    1625                 1630                 1635             


Glu Gly  Cys Gln Val Arg Val  Ala Ala Pro Ser Ser  Ser Pro Ser 
    1640                 1645                 1650             


Ala Glu  Ala Glu Tyr Trp Arg  Ile Arg Ala Met Ala  Gln Gln Val 
    1655                 1660                 1665             


Phe Met  Leu Asp Xaa Gln Cys  Ser Pro Lys Xaa Pro  Asn Asn Phe 
    1670                 1675                 1680             


Asp His  Ala Gln Ser Cys Gln  Leu Ile Ile Glu Leu  Pro Pro Asp 
    1685                 1690                 1695             


Glu Lys  Pro Asn Gly His Xaa  Lys Lys Ser Val Ser  Phe Arg Glu 
    1700                 1705                 1710             


Ile Val  Val Ser Leu Leu Ser  His Gln Val Leu Leu  Gln Asn Leu 
    1715                 1720                 1725             


Tyr Asp  Ile Leu Leu Glu Glu  Phe Val Lys Gly Pro  Ser Pro Gly 
    1730                 1735                 1740             


Glu Glu  Lys Xaa Ile Gln Val  Pro Glu Ala Lys Leu  Ala Gly Phe 
    1745                 1750                 1755             


Leu Arg  Tyr Ile Ser Met Gln  Asn Leu Ala Val Ile  Phe Asp Leu 
    1760                 1765                 1770             


Leu Leu  Asp Ser Tyr Arg Xaa  Ala Arg Glu Phe Asp  Xaa Ser Pro 
    1775                 1780                 1785             


Gly Leu  Lys Cys Leu Leu Lys  Lys Val Ser Gly Ile  Gly Gly Ala 
    1790                 1795                 1800             


Ala Asn  Leu Tyr Arg Gln Ser  Ala Met Ser Phe Asn  Ile Tyr Phe 
    1805                 1810                 1815             


His Ala  Leu Val Cys Ala Val  Leu Xaa Asn Gln Glu  Xaa Ile Xaa 
    1820                 1825                 1830             


Ala Glu  Gln Val Lys Lys Val  Leu Phe Glu Asp Asp  Glu Arg Ser 
    1835                 1840                 1845             


Xaa Asp  Ser Ser Gln Gln Cys  Ser Ser Glu Asp Glu  Asp Ile Phe 
    1850                 1855                 1860             


Glu Glu  Xaa Ala Gln Val Ser  Pro Pro Arg Gly Lys  Glu Lys Arg 
    1865                 1870                 1875             


Gln Trp  Arg Ala Arg Met Pro  Leu Leu Ser Val Gln  Pro Val Ser 
    1880                 1885                 1890             


Asn Ala  Asp Trp Val Trp Leu  Val Lys Arg Leu His  Lys Leu Cys 
    1895                 1900                 1905             


Met Glu  Leu Cys Asn Asn Tyr  Ile Gln Met His Leu  Asp Leu Glu 
    1910                 1915                 1920             


Asn Cys  Met Glu Glu Pro Pro  Ile Phe Lys Gly Asp  Pro Phe Phe 
    1925                 1930                 1935             


Ile Leu  Pro Ser Phe Gln Ser  Glu Ser Ser Xaa Pro  Ser Xaa Gly 
    1940                 1945                 1950             


Gly Phe  Ser Gly Lys Glu Xaa  Pro Ser Glu Asp Asp  Arg Ser Gln 
    1955                 1960                 1965             


Ser Arg  Glu His Met Gly Glu  Ser Leu Ser Leu Lys  Ala Gly Gly 
    1970                 1975                 1980             


Gly Asp  Leu Leu Leu Pro Pro  Ser Pro Lys Val Glu  Lys Lys Asp 
    1985                 1990                 1995             


Pro Ser  Arg Lys Lys Glu Trp  Trp Glu Asn Ala Gly  Asn Lys Ile 
    2000                 2005                 2010             


Tyr Xaa  Met Ala Ala Asp Lys  Xaa Ile Ser Lys Leu  Met Xaa Glu 
    2015                 2020                 2025             


Tyr Lys  Lys Arg Lys Gln Gln  His Asn Leu Ser Ala  Phe Pro Lys 
    2030                 2035                 2040             


Glu Val  Lys Val Glu Lys Lys  Gly Glu Pro Leu Gly  Pro Arg Gly 
    2045                 2050                 2055             


Gln Asp  Ser Pro Leu Leu Gln  Arg Pro Gln His Leu  Met Asp Gln 
    2060                 2065                 2070             


Gly Gln  Met Arg His Ser Phe  Ser Ala Gly Pro Glu  Leu Leu Arg 
    2075                 2080                 2085             


Gln Asp  Lys Arg Pro Arg Ser  Gly Ser Xaa Gly Ser  Ser Leu Ser 
    2090                 2095                 2100             


Val Ser  Val Arg Asp Ala Glu  Ala Gln Ile Gln Ala  Trp Xaa Asn 
    2105                 2110                 2115             


Met Val  Leu Xaa Val Leu Asn  Gln Ile Gln Ile Leu  Pro Asp Gln 
    2120                 2125                 2130             


Xaa Phe  Xaa Ala Leu Gln Pro  Ala Val Phe Pro Cys  Ile Ser Gln 
    2135                 2140                 2145             


Leu Xaa  Cys His Val Xaa Asp  Ile Arg Val Arg Gln  Ala Val Arg 
    2150                 2155                 2160             


Glu Trp  Leu Gly Arg Val Gly  Arg Val Tyr Asp Ile  Ile Val 
    2165                 2170                 2175         


<210> 2695
<211> 256
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<400> 2695
Met Lys Pro Ala Leu Cys Leu Val Ala Met Gly Ala Leu Val Met Asp 
1               5                   10                  15      


Ser Ser Pro Gln Cys Xaa Lys Gln Leu Leu Ser Glu Arg Phe Gly Arg 
            20                  25                  30          


Gly Ser Arg Xaa Val Asp Leu Glu Leu Glu Leu Gln Ile Glu Leu Leu 
        35                  40                  45              


Arg Glu Xaa Lys Arg Lys Tyr Glu Ser Val Leu Gln Leu Gly Arg Ala 
    50                  55                  60                  


Leu Xaa Ala His Leu Tyr Ser Leu Leu Gln Xaa Gln His Ala Leu Gly 
65                  70                  75                  80  


Asp Ala Phe Ala Asp Leu Ser Gln Lys Ser Pro Glu Leu Gln Glu Glu 
                85                  90                  95      


Phe Gly Tyr Asn Ala Glu Xaa Gln Lys Leu Leu Cys Lys Asn Gly Glu 
            100                 105                 110         


Xaa Leu Leu Gly Ala Val Asn Phe Phe Val Ser Ser Ile Asn Xaa Leu 
        115                 120                 125             


Val Xaa Lys Xaa Met Glu Asp Xaa Leu Met Xaa Val Lys Gln Tyr Glu 
    130                 135                 140                 


Ala Ala Arg Leu Glu Tyr Asp Ala Tyr Arg Xaa Asp Leu Glu Glu Leu 
145                 150                 155                 160 


Ser Leu Gly Pro Arg Asp Ala Gly Xaa Arg Gly Arg Leu Glu Ser Ala 
                165                 170                 175     


Gln Ala Xaa Phe Gln Ala His Arg Asp Lys Tyr Glu Lys Leu Arg Gly 
            180                 185                 190         


Asp Val Ala Ile Lys Leu Lys Phe Leu Glu Glu Asn Lys Ile Lys Val 
        195                 200                 205             


Met His Lys Gln Leu Leu Leu Phe His Asn Ala Val Ser Ala Tyr Phe 
    210                 215                 220                 


Ala Gly Asn Gln Lys Gln Leu Glu Gln Xaa Leu Gln Gln Phe Asn Ile 
225                 230                 235                 240 


Lys Leu Arg Pro Pro Gly Ala Glu Lys Pro Ser Trp Leu Glu Glu Gln 
                245                 250                 255     


<210> 2696
<211> 374
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<400> 2696
Met Xaa Asp Gly Ile Leu Gly Lys Ala Ala Xaa Met Glu Ile Pro Ile 
1               5                   10                  15      


His Gly Asn Gly Glu Ala Arg Gln Leu Pro Glu Asp Asp Gly Leu Glu 
            20                  25                  30          


Gln Asp Leu Gln Gln Val Met Val Ser Gly Pro Asn Leu Asn Glu Xaa 
        35                  40                  45              


Ser Ile Val Ser Gly Gly Tyr Gly Gly Ser Gly Asp Gly Leu Ile Pro 
    50                  55                  60                  


Xaa Gly Lys Ser Ile Ser Cys Ala Arg Arg Glu Val Trp Val Gly Pro 
65                  70                  75                  80  


Gln Arg Cys Leu Val Tyr Leu Arg Glu Ala Gly Val Arg Glu Leu Asp 
                85                  90                  95      


Pro Leu Gly Ser Gly Arg His Pro Ser His Ser Xaa Xaa Pro Ser Gly 
            100                 105                 110         


Pro Gly Asp Glu Val Ala Arg Gly Ile Ala Gly Glu Lys Phe Asp Ile 
        115                 120                 125             


Val Lys Lys Trp Gly Ile Asn Xaa Tyr Lys Cys Xaa Lys Gln Leu Leu 
    130                 135                 140                 


Ser Glu Arg Phe Gly Arg Gly Ser Arg Xaa Val Asp Leu Glu Leu Glu 
145                 150                 155                 160 


Leu Gln Ile Glu Leu Leu Arg Glu Xaa Lys Arg Lys Tyr Glu Ser Val 
                165                 170                 175     


Leu Gln Leu Gly Arg Ala Leu Xaa Ala His Leu Tyr Ser Leu Leu Gln 
            180                 185                 190         


Xaa Gln His Ala Leu Gly Asp Ala Phe Ala Asp Leu Ser Gln Lys Ser 
        195                 200                 205             


Pro Glu Leu Gln Glu Glu Phe Gly Tyr Asn Ala Glu Xaa Gln Lys Leu 
    210                 215                 220                 


Leu Cys Lys Asn Gly Glu Xaa Leu Leu Gly Ala Val Asn Phe Phe Val 
225                 230                 235                 240 


Ser Ser Ile Asn Xaa Leu Val Xaa Lys Xaa Met Glu Asp Xaa Leu Met 
                245                 250                 255     


Xaa Val Lys Gln Tyr Glu Ala Ala Arg Leu Glu Tyr Asp Ala Tyr Arg 
            260                 265                 270         


Xaa Asp Leu Glu Glu Leu Ser Leu Gly Pro Arg Asp Ala Gly Xaa Arg 
        275                 280                 285             


Gly Arg Leu Glu Ser Ala Gln Ala Xaa Phe Gln Ala His Arg Asp Lys 
    290                 295                 300                 


Tyr Glu Lys Leu Arg Gly Asp Val Ala Ile Lys Leu Lys Phe Leu Glu 
305                 310                 315                 320 


Glu Asn Lys Ile Lys Val Met His Lys Gln Leu Leu Leu Phe His Asn 
                325                 330                 335     


Ala Val Ser Ala Tyr Phe Ala Gly Asn Gln Lys Gln Leu Glu Gln Xaa 
            340                 345                 350         


Leu Gln Gln Phe Asn Ile Lys Leu Arg Pro Pro Gly Ala Glu Lys Pro 
        355                 360                 365             


Ser Trp Leu Glu Glu Gln 
    370                 


<210> 2697
<211> 159
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<400> 2697
Met Xaa Asp Gly Ile Leu Gly Lys Ala Ala Xaa Met Glu Ile Pro Ile 
1               5                   10                  15      


His Gly Asn Gly Glu Ala Arg Gln Leu Pro Glu Asp Asp Gly Leu Glu 
            20                  25                  30          


Gln Asp Leu Gln Gln Val Met Val Ser Gly Pro Asn Leu Asn Glu Xaa 
        35                  40                  45              


Ser Ile Val Ser Gly Gly Tyr Gly Gly Ser Gly Asp Gly Leu Ile Pro 
    50                  55                  60                  


Xaa Gly Ser Gly Arg His Pro Ser His Ser Xaa Xaa Pro Ser Gly Pro 
65                  70                  75                  80  


Gly Asp Glu Val Ala Arg Gly Ile Ala Gly Glu Lys Phe Asp Ile Val 
                85                  90                  95      


Lys Lys Trp Gly Ile Asn Xaa Tyr Lys Cys Xaa Lys Gln Leu Leu Ser 
            100                 105                 110         


Glu Arg Phe Gly Arg Gly Ser Arg Xaa Val Asp Leu Glu Leu Glu Leu 
        115                 120                 125             


Gln Ile Glu Leu Leu Arg Glu Xaa Lys Arg Lys Arg Asn Leu Ala Xaa 
    130                 135                 140                 


Met Gln Arg His Arg Asn Tyr Tyr Ala Arg Met Gly Lys Arg Cys 
145                 150                 155                 


<210> 2698
<211> 341
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<400> 2698
Met Xaa Asp Gly Ile Leu Gly Lys Ala Ala Xaa Met Glu Ile Pro Ile 
1               5                   10                  15      


His Gly Asn Gly Glu Ala Arg Gln Leu Pro Glu Asp Asp Gly Leu Glu 
            20                  25                  30          


Gln Asp Leu Gln Gln Val Met Val Ser Gly Pro Asn Leu Asn Glu Xaa 
        35                  40                  45              


Ser Ile Val Ser Gly Gly Tyr Gly Gly Ser Gly Asp Gly Leu Ile Pro 
    50                  55                  60                  


Xaa Gly Ser Gly Arg His Pro Ser His Ser Xaa Xaa Pro Ser Gly Pro 
65                  70                  75                  80  


Gly Asp Glu Val Ala Arg Gly Ile Ala Gly Glu Lys Phe Asp Ile Val 
                85                  90                  95      


Lys Lys Trp Gly Ile Asn Xaa Tyr Lys Cys Xaa Lys Gln Leu Leu Ser 
            100                 105                 110         


Glu Arg Phe Gly Arg Gly Ser Arg Xaa Val Asp Leu Glu Leu Glu Leu 
        115                 120                 125             


Gln Ile Glu Leu Leu Arg Glu Xaa Lys Arg Lys Tyr Glu Ser Val Leu 
    130                 135                 140                 


Gln Leu Gly Arg Ala Leu Xaa Ala His Leu Tyr Ser Leu Leu Gln Xaa 
145                 150                 155                 160 


Gln His Ala Leu Gly Asp Ala Phe Ala Asp Leu Ser Gln Lys Ser Pro 
                165                 170                 175     


Glu Leu Gln Glu Glu Phe Gly Tyr Asn Ala Glu Xaa Gln Lys Leu Leu 
            180                 185                 190         


Cys Lys Asn Gly Glu Xaa Leu Leu Gly Ala Val Asn Phe Phe Val Ser 
        195                 200                 205             


Ser Ile Asn Xaa Leu Val Xaa Lys Xaa Met Glu Asp Xaa Leu Met Xaa 
    210                 215                 220                 


Val Lys Gln Tyr Glu Ala Ala Arg Leu Glu Tyr Asp Ala Tyr Arg Xaa 
225                 230                 235                 240 


Asp Leu Glu Glu Leu Ser Leu Gly Pro Arg Asp Ala Gly Xaa Arg Gly 
                245                 250                 255     


Arg Leu Glu Ser Ala Gln Ala Xaa Phe Gln Ala His Arg Asp Lys Tyr 
            260                 265                 270         


Glu Lys Leu Arg Gly Asp Val Ala Ile Lys Leu Lys Phe Leu Glu Glu 
        275                 280                 285             


Asn Lys Ile Lys Val Met His Lys Gln Leu Leu Leu Phe His Asn Ala 
    290                 295                 300                 


Val Ser Ala Tyr Phe Ala Gly Asn Gln Lys Gln Leu Glu Gln Xaa Leu 
305                 310                 315                 320 


Gln Gln Phe Asn Ile Lys Leu Arg Pro Pro Gly Ala Glu Lys Pro Ser 
                325                 330                 335     


Trp Leu Glu Glu Gln 
            340     


<210> 2699
<211> 202
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<400> 2699
Met Xaa Asp Gly Ile Leu Gly Lys Ala Ala Xaa Met Glu Ile Pro Ile 
1               5                   10                  15      


His Gly Asn Gly Glu Ala Arg Gln Leu Pro Glu Asp Asp Gly Leu Glu 
            20                  25                  30          


Gln Asp Leu Gln Gln Val Met Val Ser Gly Pro Asn Leu Asn Glu Xaa 
        35                  40                  45              


Ser Ile Val Ser Gly Gly Tyr Gly Gly Ser Gly Asp Gly Leu Ile Pro 
    50                  55                  60                  


Xaa Gly Ser Gly Arg His Pro Ser His Ser Xaa Xaa Pro Ser Gly Pro 
65                  70                  75                  80  


Gly Asp Glu Val Ala Arg Gly Ile Ala Gly Glu Lys Phe Asp Ile Val 
                85                  90                  95      


Lys Lys Trp Gly Ile Asn Xaa Tyr Lys Cys Xaa Lys Gln Leu Leu Ser 
            100                 105                 110         


Glu Arg Phe Gly Arg Gly Ser Arg Xaa Val Asp Leu Glu Leu Glu Leu 
        115                 120                 125             


Gln Ile Glu Leu Leu Arg Glu Xaa Lys Arg Lys Tyr Glu Ser Val Leu 
    130                 135                 140                 


Gln Leu Gly Arg Ala Leu Xaa Ala His Leu Tyr Ser Leu Leu Gln Xaa 
145                 150                 155                 160 


Gln His Ala Leu Gly Asp Ala Phe Ala Asp Leu Ser Gln Lys Ser Pro 
                165                 170                 175     


Glu Leu Gln Pro Xaa Gly Arg Xaa Pro Ser Gly Trp Ala Gln Pro Tyr 
            180                 185                 190         


Pro Gln Gln His Ser Pro Val Glu Ala Ala 
        195                 200         


<210> 2700
<211> 303
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<400> 2700
Met Val Ser Gly Pro Asn Leu Asn Glu Xaa Ser Ile Val Ser Gly Gly 
1               5                   10                  15      


Tyr Gly Gly Ser Gly Asp Gly Leu Ile Pro Xaa Gly Ser Gly Arg His 
            20                  25                  30          


Pro Ser His Ser Xaa Xaa Pro Ser Gly Pro Gly Asp Glu Val Ala Arg 
        35                  40                  45              


Gly Ile Ala Gly Glu Lys Phe Asp Ile Val Lys Lys Trp Gly Ile Asn 
    50                  55                  60                  


Xaa Tyr Lys Cys Xaa Lys Gln Leu Leu Ser Glu Arg Phe Gly Arg Gly 
65                  70                  75                  80  


Ser Arg Xaa Val Asp Leu Glu Leu Glu Leu Gln Ile Glu Leu Leu Arg 
                85                  90                  95      


Glu Xaa Lys Arg Lys Tyr Glu Ser Val Leu Gln Leu Gly Arg Ala Leu 
            100                 105                 110         


Xaa Ala His Leu Tyr Ser Leu Leu Gln Xaa Gln His Ala Leu Gly Asp 
        115                 120                 125             


Ala Phe Ala Asp Leu Ser Gln Lys Ser Pro Glu Leu Gln Glu Glu Phe 
    130                 135                 140                 


Gly Tyr Asn Ala Glu Xaa Gln Lys Leu Leu Cys Lys Asn Gly Glu Xaa 
145                 150                 155                 160 


Leu Leu Gly Ala Val Asn Phe Phe Val Ser Ser Ile Asn Xaa Leu Val 
                165                 170                 175     


Xaa Lys Xaa Met Glu Asp Xaa Leu Met Xaa Val Lys Gln Tyr Glu Ala 
            180                 185                 190         


Ala Arg Leu Glu Tyr Asp Ala Tyr Arg Xaa Asp Leu Glu Glu Leu Ser 
        195                 200                 205             


Leu Gly Pro Arg Asp Ala Gly Xaa Arg Gly Arg Leu Glu Ser Ala Gln 
    210                 215                 220                 


Ala Xaa Phe Gln Ala His Arg Asp Lys Tyr Glu Lys Leu Arg Gly Asp 
225                 230                 235                 240 


Val Ala Ile Lys Leu Lys Phe Leu Glu Glu Asn Lys Ile Lys Val Met 
                245                 250                 255     


His Lys Gln Leu Leu Leu Phe His Asn Ala Val Ser Ala Tyr Phe Ala 
            260                 265                 270         


Gly Asn Gln Lys Gln Leu Glu Gln Xaa Leu Gln Gln Phe Asn Ile Lys 
        275                 280                 285             


Leu Arg Pro Pro Gly Ala Glu Lys Pro Ser Trp Leu Glu Glu Gln 
    290                 295                 300             


<210> 2701
<211> 154
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<400> 2701
Met Ser Leu Ser Lys Ile Xaa Xaa Xaa Val Gly Leu Asn Ile Gly Xaa 
1               5                   10                  15      


Val Asp Val Gly Lys Ala Arg Leu Met Phe Trp Asp Leu Gly Gly Gln 
            20                  25                  30          


Glu Glu Leu Gln Ser Leu Trp Asp Lys Tyr Tyr Ala Glu Cys His Gly 
        35                  40                  45              


Val Ile Tyr Val Ile Asp Ser Xaa Asp Glu Glu Arg Leu Ala Glu Ser 
    50                  55                  60                  


Lys Gln Ala Phe Glu Lys Val Val Xaa Ser Glu Ala Leu Cys Gly Val 
65                  70                  75                  80  


Pro Val Leu Val Leu Ala Asn Lys Gln Asp Val Glu Xaa Cys Leu Ser 
                85                  90                  95      


Ile Pro Asp Ile Lys Xaa Ala Phe Ser Asp Cys Xaa Ser Lys Ile Gly 
            100                 105                 110         


Arg Arg Asp Cys Leu Xaa Gln Ala Cys Ser Ala Leu Xaa Gly Lys Gly 
        115                 120                 125             


Val Arg Glu Gly Ile Glu Trp Met Val Lys Cys Val Val Arg Asn Val 
    130                 135                 140                 


His Arg Pro Pro Arg Gln Arg Asp Ile Xaa 
145                 150                 


<210> 2702
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 2702
Met Tyr Xaa Leu Leu Ser Gly Leu Tyr Lys Tyr Met Phe Gln Lys Asp 
1               5                   10                  15      


Glu Tyr Cys Ile Leu Ile Leu Gly Leu Asp Asn Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Phe Leu Glu Gln Ser Lys Xaa Arg Phe Asn Lys Asn Tyr Lys Gly Met 
        35                  40                  45              


Ser Leu Ser Lys Ile Xaa Xaa Xaa Val Gly Leu Asn Ile Gly Xaa Val 
    50                  55                  60                  


Asp Val Gly Lys Ala Arg Leu Met Phe Trp Asp Leu Gly Gly Gln Glu 
65                  70                  75                  80  


Glu Leu Gln Ser Leu Trp Asp Lys Tyr Tyr Ala Glu Cys His Gly Val 
                85                  90                  95      


Ile Tyr Val Ile Asp Ser Xaa Asp Glu Glu Arg Leu Ala Glu Ser Lys 
            100                 105                 110         


Gln Ala Phe Asp Val Pro Leu Asn Pro 
        115                 120     


<210> 2703
<211> 173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<400> 2703
Met Tyr Xaa Leu Leu Ser Gly Leu Tyr Lys Tyr Met Phe Gln Lys Asp 
1               5                   10                  15      


Glu Tyr Cys Ile Leu Ile Leu Gly Leu Asp Asn Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Phe Leu Glu Gln Ser Lys Xaa Arg Phe Asn Lys Asn Tyr Lys Gly Met 
        35                  40                  45              


Ser Leu Ser Lys Ile Xaa Xaa Xaa Val Gly Leu Asn Ile Gly Xaa Val 
    50                  55                  60                  


Asp Val Gly Lys Ala Arg Leu Met Phe Trp Asp Leu Gly Gly Gln Glu 
65                  70                  75                  80  


Glu Leu Gln Ser Leu Trp Asp Lys Tyr Tyr Ala Glu Cys His Gly Val 
                85                  90                  95      


Ile Tyr Val Ile Asp Ser Xaa Asp Glu Glu Arg Leu Ala Glu Ser Lys 
            100                 105                 110         


Gln Ala Phe Glu Lys Val Val Xaa Ser Glu Ala Leu Cys Gly Val Pro 
        115                 120                 125             


Val Leu Val Leu Ala Asn Lys Gln Asp Val Glu Xaa Cys Leu Ser Ile 
    130                 135                 140                 


Pro Asp Ile Lys Xaa Ala Phe Ser Asp Cys Xaa Ser Lys Ile Gly Arg 
145                 150                 155                 160 


Arg Asp Cys Leu Xaa Gln Ala Cys Ser Ala Leu Xaa Gly 
                165                 170             


<210> 2704
<211> 201
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<400> 2704
Met Tyr Xaa Leu Leu Ser Gly Leu Tyr Lys Tyr Met Phe Gln Lys Asp 
1               5                   10                  15      


Glu Tyr Cys Ile Leu Ile Leu Gly Leu Asp Asn Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Phe Leu Glu Gln Ser Lys Xaa Arg Phe Asn Lys Asn Tyr Lys Gly Met 
        35                  40                  45              


Ser Leu Ser Lys Ile Xaa Xaa Xaa Val Gly Leu Asn Ile Gly Xaa Val 
    50                  55                  60                  


Asp Val Gly Lys Ala Arg Leu Met Phe Trp Asp Leu Gly Gly Gln Glu 
65                  70                  75                  80  


Glu Leu Gln Ser Leu Trp Asp Lys Tyr Tyr Ala Glu Cys His Gly Val 
                85                  90                  95      


Ile Tyr Val Ile Asp Ser Xaa Asp Glu Glu Arg Leu Ala Glu Ser Lys 
            100                 105                 110         


Gln Ala Phe Glu Lys Val Val Xaa Ser Glu Ala Leu Cys Gly Val Pro 
        115                 120                 125             


Val Leu Val Leu Ala Asn Lys Gln Asp Val Glu Xaa Cys Leu Ser Ile 
    130                 135                 140                 


Pro Asp Ile Lys Xaa Ala Phe Ser Asp Cys Xaa Ser Lys Ile Gly Arg 
145                 150                 155                 160 


Arg Asp Cys Leu Xaa Gln Ala Cys Ser Ala Leu Xaa Gly Lys Gly Val 
                165                 170                 175     


Arg Glu Gly Ile Glu Trp Met Val Lys Cys Val Val Arg Asn Val His 
            180                 185                 190         


Arg Pro Pro Arg Gln Arg Asp Ile Xaa 
        195                 200     


<210> 2705
<211> 315
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<400> 2705
Met Arg Asn Arg Met Ala Pro Glu Asn Pro Gln Pro Asp Pro Phe Ile 
1               5                   10                  15      


Asn Arg Asn Tyr Ser Asn Met Lys Val Ile Pro Pro Gln Asp Pro Ala 
            20                  25                  30          


Ser Pro Ser Phe Xaa Leu Leu Ser Lys Leu Glu Cys Ser Gly Xaa Val 
        35                  40                  45              


Ser Ala Tyr Cys Ser Leu Asn Leu Pro Gly Ser Xaa Asp Pro Pro Xaa 
    50                  55                  60                  


Ser Ala Ser Arg Val Ala Ala Xaa Xaa Ala Ile Arg Arg Arg His Lys 
65                  70                  75                  80  


Glu Arg Xaa Ser Phe Xaa His Gln Gln Tyr Glu Glu Leu Glu Ala Leu 
                85                  90                  95      


Phe Ser Gln Xaa Met Phe Pro Asp Arg Asn Leu Gln Glu Lys Leu Ala 
            100                 105                 110         


Leu Arg Leu Asp Leu Pro Glu Ser Xaa Val Lys Val Trp Phe Arg Asn 
        115                 120                 125             


Arg Arg Phe Lys Leu Lys Lys Gln Gln Gln Gln Gln Ser Ala Lys Gln 
    130                 135                 140                 


Arg Asn Gln Ile Leu Pro Ser Lys Lys Asn Val Pro Xaa Ser Pro Arg 
145                 150                 155                 160 


Xaa Ser Pro Ser Pro Tyr Ala Phe Ser Pro Val Ile Ser Asp Phe Tyr 
                165                 170                 175     


Ser Ser Leu Pro Ser Gln Pro Leu Asp Pro Ser Asn Trp Ala Trp Asn 
            180                 185                 190         


Ser Xaa Phe Xaa Glu Ser Ser Xaa Ser Asp Phe Gln Met Gln Asp Xaa 
        195                 200                 205             


Gln Trp Glu Arg Leu Val Ala Ser Val Pro Ala Leu Tyr Ser Asp Ala 
    210                 215                 220                 


Tyr Asp Ile Phe Gln Ile Ile Glu Leu Tyr Asn Leu Pro Asp Glu Asn 
225                 230                 235                 240 


Glu Ile Ser Ser Ser Ser Phe His Cys Leu Tyr Gln Tyr Leu Ser Pro 
                245                 250                 255     


Xaa Lys Tyr Gln Val Gly Gly Gln Gly Ser Ser Leu Ser Ile Phe Ala 
            260                 265                 270         


Gly Pro Ala Val Gly Leu Ser Pro Ala Gln Xaa Trp Pro Asn Met Xaa 
        275                 280                 285             


Ser Gln Ala Phe Glu Ala Tyr Ser Leu Xaa Asp Ser Leu Glu Phe Gln 
    290                 295                 300                 


Lys Xaa Ser Asn Met Val Asp Leu Gly Phe Leu 
305                 310                 315 


<210> 2706
<211> 192
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 2706
Met Asp Pro Leu Ser Glu Leu Gln Asp Asp Leu Xaa Leu Asp Asp Xaa 
1               5                   10                  15      


Ser Glu Ala Leu Asn Gln Leu Lys Leu Ala Ser Ile Asp Glu Lys Asn 
            20                  25                  30          


Trp Pro Ser Asp Glu Met Pro Asp Phe Pro Lys Ser Asp Asp Ser Lys 
        35                  40                  45              


Ser Ser Ser Pro Glu Leu Val Xaa His Leu Lys Trp Asp Asp Pro Tyr 
    50                  55                  60                  


Tyr Asp Ile Ala Arg His Gln Ile Val Glu Val Ala Gly Asp Asp Lys 
65                  70                  75                  80  


Tyr Gly Arg Lys Ile Ile Val Phe Ser Ala Cys Arg Met Pro Pro Ser 
                85                  90                  95      


His Gln Leu Asp His Ser Lys Leu Leu Gly Tyr Leu Lys His Xaa Leu 
            100                 105                 110         


Asp Gln Tyr Val Glu Ser Asp Tyr Xaa Leu Leu Tyr Leu His His Gly 
        115                 120                 125             


Leu Xaa Ser Asp Asn Lys Pro Ser Leu Ser Trp Leu Arg Asp Ala Tyr 
    130                 135                 140                 


Arg Glu Phe Asp Arg Lys Tyr Lys Lys Asn Ile Lys Ala Leu Tyr Ile 
145                 150                 155                 160 


Val His Pro Xaa Met Phe Ile Lys Xaa Leu Leu Ile Leu Phe Lys Pro 
                165                 170                 175     


Leu Ile Ser Phe Lys Phe Gly Gln Lys Ile Phe Tyr Val Asn Tyr Leu 
            180                 185                 190         


<210> 2707
<211> 439
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<400> 2707
Met Asp Pro Leu Ser Glu Leu Gln Asp Asp Leu Xaa Leu Asp Asp Xaa 
1               5                   10                  15      


Ser Glu Ala Leu Asn Gln Leu Lys Leu Ala Ser Ile Asp Glu Lys Asn 
            20                  25                  30          


Trp Pro Ser Asp Glu Met Pro Asp Phe Pro Lys Ser Asp Asp Ser Lys 
        35                  40                  45              


Ser Ser Ser Pro Glu Leu Val Xaa His Leu Lys Trp Asp Asp Pro Tyr 
    50                  55                  60                  


Tyr Asp Ile Ala Arg His Gln Ile Val Glu Val Ala Gly Asp Asp Lys 
65                  70                  75                  80  


Tyr Gly Arg Lys Ile Ile Val Phe Ser Ala Cys Arg Met Pro Pro Ser 
                85                  90                  95      


His Gln Leu Asp His Ser Lys Leu Leu Gly Tyr Leu Lys His Xaa Leu 
            100                 105                 110         


Asp Gln Tyr Val Glu Ser Asp Tyr Xaa Leu Leu Tyr Leu His His Gly 
        115                 120                 125             


Leu Xaa Ser Asp Asn Lys Pro Ser Leu Ser Trp Leu Arg Asp Ala Tyr 
    130                 135                 140                 


Arg Glu Phe Asp Arg Lys Tyr Lys Lys Asn Ile Lys Ala Leu Tyr Ile 
145                 150                 155                 160 


Val His Pro Xaa Met Phe Ile Lys Xaa Leu Leu Ile Leu Phe Lys Pro 
                165                 170                 175     


Leu Ile Ser Phe Lys Phe Gly Gln Lys Ile Phe Tyr Val Asn Tyr Leu 
            180                 185                 190         


Ser Glu Leu Ser Glu His Val Lys Leu Glu Gln Leu Gly Ile Pro Arg 
        195                 200                 205             


Gln Val Leu Lys Tyr Asp Asp Phe Leu Lys Ser Xaa Gln Lys Ser Pro 
    210                 215                 220                 


Ala Xaa Ala Pro Lys Pro Met Pro Pro Arg Pro Pro Leu Pro Asn Gln 
225                 230                 235                 240 


Gln Phe Gly Val Ser Leu Gln His Leu Gln Glu Lys Asn Pro Glu Gln 
                245                 250                 255     


Glu Pro Ile Pro Ile Val Leu Arg Glu Xaa Val Ala Tyr Leu Gln Ala 
            260                 265                 270         


His Ala Leu Xaa Xaa Glu Gly Ile Phe Arg Arg Ser Ala Asn Xaa Gln 
        275                 280                 285             


Val Val Arg Glu Val Gln Gln Lys Tyr Asn Met Gly Leu Pro Val Asp 
    290                 295                 300                 


Phe Asp Gln Tyr Asn Glu Leu His Leu Pro Ala Val Ile Leu Lys Xaa 
305                 310                 315                 320 


Phe Leu Arg Glu Leu Pro Glu Pro Leu Leu Xaa Phe Asp Leu Tyr Pro 
                325                 330                 335     


His Val Val Gly Phe Leu Asn Ile Asp Glu Ser Gln Arg Val Pro Ala 
            340                 345                 350         


Xaa Leu Gln Val Leu Gln Xaa Leu Pro Glu Glu Asn Tyr Gln Val Leu 
        355                 360                 365             


Arg Phe Leu Xaa Ala Phe Leu Val Gln Ile Ser Ala His Ser Asp Gln 
    370                 375                 380                 


Asn Lys Met Xaa Asn Xaa Asn Leu Ala Val Val Phe Gly Pro Asn Leu 
385                 390                 395                 400 


Leu Trp Ala Lys Asp Ala Ala Ile Xaa Leu Lys Ala Ile Asn Pro Ile 
                405                 410                 415     


Asn Xaa Phe Xaa Lys Phe Leu Leu Asp His Gln Gly Glu Leu Phe Pro 
            420                 425                 430         


Ser Pro Asp Pro Ser Gly Leu 
        435                 


<210> 2708
<211> 334
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<400> 2708
Xaa Leu Ser Glu Leu Gln Asp Asp Leu Xaa Leu Asp Asp Xaa Ser Glu 
1               5                   10                  15      


Ala Leu Asn Gln Leu Lys Leu Ala Ser Ile Asp Glu Lys Asn Trp Pro 
            20                  25                  30          


Ser Asp Glu Met Pro Asp Phe Pro Lys Ser Asp Asp Ser Lys Ser Ser 
        35                  40                  45              


Ser Pro Glu Leu Val Xaa His Leu Lys Trp Asp Asp Pro Tyr Tyr Asp 
    50                  55                  60                  


Ile Ala Arg His Gln Ile Val Glu Val Ala Gly Asp Asp Lys Tyr Gly 
65                  70                  75                  80  


Arg Lys Ile Ile Val Phe Ser Ala Cys Arg Met Pro Pro Ser His Gln 
                85                  90                  95      


Leu Asp His Ser Lys Leu Leu Gly Tyr Lys Lys Asn Ile Lys Ala Leu 
            100                 105                 110         


Tyr Ile Val His Pro Xaa Met Phe Ile Lys Xaa Leu Leu Ile Leu Phe 
        115                 120                 125             


Lys Pro Leu Ile Ser Phe Lys Phe Gly Gln Lys Ile Phe Tyr Val Asn 
    130                 135                 140                 


Tyr Leu Ser Glu Leu Ser Glu His Val Lys Leu Glu Gln Leu Gly Ile 
145                 150                 155                 160 


Pro Arg Gln Val Leu Lys Tyr Asp Asp Phe Leu Lys Ser Xaa Gln Lys 
                165                 170                 175     


Ser Pro Ala Xaa Ala Pro Lys Pro Met Pro Pro Arg Pro Pro Leu Pro 
            180                 185                 190         


Asn Gln Gln Phe Gly Val Ser Leu Gln His Leu Gln Glu Lys Asn Pro 
        195                 200                 205             


Glu Gln Glu Pro Ile Pro Ile Val Leu Arg Glu Xaa Val Ala Tyr Leu 
    210                 215                 220                 


Gln Ala His Ala Leu Xaa Xaa Glu Gly Ile Phe Arg Arg Ser Ala Asn 
225                 230                 235                 240 


Xaa Gln Val Val Arg Glu Val Gln Gln Lys Tyr Asn Met Gly Leu Pro 
                245                 250                 255     


Val Asp Phe Asp Gln Tyr Asn Glu Leu His Leu Pro Ala Val Ile Leu 
            260                 265                 270         


Lys Xaa Phe Leu Arg Glu Leu Pro Glu Pro Leu Leu Xaa Phe Asp Leu 
        275                 280                 285             


Tyr Pro His Val Val Gly Phe Leu Asn Ile Asp Glu Ser Gln Arg Val 
    290                 295                 300                 


Pro Ala Xaa Leu Gln Val Leu Gln Xaa Leu Pro Glu Glu Asn Tyr Gln 
305                 310                 315                 320 


Val Leu Arg Phe Leu Xaa Ala Phe Leu Val Gln Ile Ser Ala 
                325                 330                 


<210> 2709
<211> 786
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<400> 2709
Met Gly Leu Gln Pro Leu Glu Phe Ser Asp Cys Tyr Leu Asp Ser Pro 
1               5                   10                  15      


Trp Phe Arg Glu Arg Ile Arg Ala His Glu Ala Glu Leu Glu Arg Xaa 
            20                  25                  30          


Asn Lys Phe Ile Lys Glu Leu Ile Lys Asp Gly Lys Asn Leu Ile Ala 
        35                  40                  45              


Ala Xaa Lys Ser Leu Ser Val Ala Gln Arg Lys Phe Ala His Ser Leu 
    50                  55                  60                  


Arg Asp Phe Lys Phe Glu Phe Ile Gly Asp Ala Val Xaa Asp Asp Glu 
65                  70                  75                  80  


Arg Cys Ile Asp Ala Ser Leu Arg Glu Phe Ser Asn Phe Leu Lys Asn 
                85                  90                  95      


Leu Glu Glu Gln Arg Glu Ile Met Ala Leu Ser Val Xaa Glu Xaa Leu 
            100                 105                 110         


Ile Lys Pro Leu Glu Lys Phe Arg Lys Glu Gln Leu Gly Ala Val Lys 
        115                 120                 125             


Glu Glu Lys Lys Lys Phe Asp Lys Glu Xaa Glu Lys Asn Tyr Ser Leu 
    130                 135                 140                 


Ile Asp Lys His Leu Asn Leu Ser Ala Lys Lys Lys Asp Ser His Leu 
145                 150                 155                 160 


Gln Glu Ala Asp Ile Gln Val Glu Gln Asn Arg Gln His Phe Tyr Glu 
                165                 170                 175     


Leu Ser Leu Glu Tyr Val Cys Lys Leu Gln Glu Ile Gln Glu Arg Lys 
            180                 185                 190         


Lys Phe Glu Phe Val Glu Pro Met Leu Ser Phe Phe Gln Gly Met Phe 
        195                 200                 205             


Xaa Phe Tyr His Gln Gly His Glu Leu Ala Lys Asp Phe Asn His Tyr 
    210                 215                 220                 


Lys Met Glu Leu Gln Ile Asn Ile Gln Asn Xaa Arg Asn Arg Phe Glu 
225                 230                 235                 240 


Gly Xaa Arg Ser Glu Val Glu Glu Leu Met Asn Lys Ile Arg Gln Asn 
                245                 250                 255     


Pro Lys Asp His Lys Arg Ala Ser Gln Phe Xaa Ala Glu Gly Tyr Leu 
            260                 265                 270         


Tyr Val Gln Glu Lys Arg Pro Ala Pro Phe Gly Ser Ser Trp Val Lys 
        275                 280                 285             


His Tyr Cys Met Tyr Arg Lys Ala Ala Lys Lys Phe Asn Met Ile Pro 
    290                 295                 300                 


Phe Glu His Arg Ser Gly Gly Lys Leu Gly Asp Gly Glu Val Phe Phe 
305                 310                 315                 320 


Leu Lys Glu Cys Xaa Lys Arg His Xaa Asp Ser Ile Asp Arg Arg Phe 
                325                 330                 335     


Cys Phe Asp Ile Glu Ala Ala Asp Arg Pro Gly Val Ser Leu Xaa Met 
            340                 345                 350         


Gln Ala Phe Ser Glu Glu Glu Arg Lys Gln Trp Leu Glu Ala Leu Gly 
        355                 360                 365             


Gly Lys Glu Ala Leu Ser His Ser Phe Asn Xaa Ala Ile Ile Pro Arg 
    370                 375                 380                 


Pro Glu Gly Asn Ala Gln Leu Asp Lys Met Gly Phe Xaa Ile Ile Arg 
385                 390                 395                 400 


Lys Cys Ile Ser Ala Val Glu Xaa Arg Gly Ile Asn Asp Gln Gly Leu 
                405                 410                 415     


Tyr Arg Val Val Gly Val Ser Ser Lys Val Gln Arg Leu Leu Ser Met 
            420                 425                 430         


Leu Met Asp Val Lys Xaa Cys Asn Glu Val Asp Leu Glu Asn Ser Ala 
        435                 440                 445             


Asp Trp Glu Val Lys Xaa Ile Xaa Ser Ala Leu Lys Gln Tyr Leu Arg 
    450                 455                 460                 


Ser Leu Pro Glu Pro Leu Met Xaa Tyr Glu Leu His Gly Asp Phe Ile 
465                 470                 475                 480 


Val Pro Ala Lys Ser Gly Ser Pro Glu Ser Arg Val Asn Ala Ile His 
                485                 490                 495     


Phe Leu Val His Lys Leu Pro Glu Lys Asn Lys Glu Met Leu Asp Ile 
            500                 505                 510         


Leu Val Lys His Leu Xaa Asn Val Ser Asn His Ser Lys Gln Asn Leu 
        515                 520                 525             


Met Xaa Val Ala Asn Leu Gly Val Val Phe Gly Pro Xaa Leu Met Arg 
    530                 535                 540                 


Pro Gln Glu Glu Xaa Val Ala Ala Leu Met Asp Leu Lys Phe Gln Asn 
545                 550                 555                 560 


Ile Val Val Glu Ile Leu Ile Glu Asn His Glu Lys Ile Phe Arg Xaa 
                565                 570                 575     


Pro Pro Asp Xaa Xaa Phe Pro Glu Pro Xaa Cys Leu Ser Ala Ser Pro 
            580                 585                 590         


Pro Asn Ala Pro Pro Arg Gln Ser Lys Arg Gln Gly Gln Arg Xaa Lys 
        595                 600                 605             


Arg Pro Val Ala Val Tyr Asn Leu Cys Leu Glu Leu Glu Asp Gly Asp 
    610                 615                 620                 


Asn Pro Tyr Pro Ser Lys Glu Asp Xaa Pro Xaa Ser Ser Leu Asp Ser 
625                 630                 635                 640 


Leu Ser Ser Pro Ser Pro Val Xaa Xaa Ala Val Pro Gly Pro Pro Gly 
                645                 650                 655     


Pro Asp Lys Asn His Leu Leu Ala Asp Gly Gly Ser Phe Gly Asp Trp 
            660                 665                 670         


Ala Ser Xaa Ile Pro Gly Gln Xaa Arg Ser Ser Met Val Gln Trp Leu 
        675                 680                 685             


Asn Pro Gln Ser Pro Xaa Xaa Xaa Ser Ser Asn Ser Ala Val Xaa Pro 
    690                 695                 700                 


Leu Ser Pro Gly Ser Ser Pro Phe Pro Phe Ser Pro Pro Ala Xaa Val 
705                 710                 715                 720 


Ala Asp Lys Pro Pro Glu Ser Ile Arg Ser Arg Lys Ala Arg Ala Val 
                725                 730                 735     


Tyr Pro Cys Glu Ala Glu His Ser Ser Glu Leu Ser Phe Glu Ile Gly 
            740                 745                 750         


Ala Ile Phe Glu Asp Val Gln Xaa Ser Arg Glu Pro Gly Trp Leu Glu 
        755                 760                 765             


Gly Xaa Leu Asn Gly Lys Arg Gly Leu Ile Pro Gln Asn Tyr Val Lys 
    770                 775                 780                 


Leu Leu 
785     


<210> 2710
<211> 413
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<400> 2710
Xaa Cys Xaa Lys Arg His Xaa Asp Ser Ile Asp Arg Arg Phe Cys Phe 
1               5                   10                  15      


Asp Ile Glu Ala Ala Asp Arg Pro Gly Val Ser Leu Xaa Met Gln Ala 
            20                  25                  30          


Phe Ser Glu Glu Glu Arg Lys Gln Trp Leu Glu Ala Leu Gly Gly Lys 
        35                  40                  45              


Glu Ala Leu Ser His Ser Phe Asn Xaa Ala Ile Ile Pro Arg Pro Glu 
    50                  55                  60                  


Gly Asn Ala Gln Leu Asp Lys Met Gly Phe Xaa Ile Ile Arg Lys Cys 
65                  70                  75                  80  


Ile Ser Ala Val Glu Xaa Arg Gly Ile Asn Asp Gln Gly Leu Tyr Arg 
                85                  90                  95      


Val Val Gly Val Ser Ser Lys Val Gln Arg Leu Leu Ser Met Leu Met 
            100                 105                 110         


Asp Val Lys Xaa Cys Asn Glu Val Asp Leu Glu Asn Ser Ala Asp Trp 
        115                 120                 125             


Glu Val Lys Xaa Ile Xaa Ser Ala Leu Lys Gln Tyr Leu Arg Ser Leu 
    130                 135                 140                 


Pro Glu Pro Leu Met Xaa Tyr Glu Leu His Gly Asp Phe Ile Val Pro 
145                 150                 155                 160 


Ala Lys Ser Gly Ser Pro Glu Ser Arg Val Asn Ala Ile His Phe Leu 
                165                 170                 175     


Val His Lys Leu Pro Glu Lys Asn Lys Glu Met Leu Asp Ile Leu Val 
            180                 185                 190         


Lys His Leu Xaa Asn Val Ser Asn His Ser Lys Gln Asn Leu Met Xaa 
        195                 200                 205             


Val Ala Asn Leu Gly Val Val Phe Gly Pro Xaa Leu Met Arg Pro Gln 
    210                 215                 220                 


Glu Glu Xaa Val Ala Ala Leu Met Asp Leu Lys Phe Gln Asn Ile Val 
225                 230                 235                 240 


Val Glu Ile Leu Ile Glu Asn His Glu Lys Ile Phe Arg Xaa Pro Pro 
                245                 250                 255     


Asp Xaa Xaa Phe Pro Glu Pro Xaa Cys Leu Ser Ala Ser Pro Pro Asn 
            260                 265                 270         


Ala Pro Pro Arg Gln Ser Lys Arg Gln Gly Gln Arg Xaa Lys Arg Pro 
        275                 280                 285             


Val Ala Val Tyr Asn Leu Cys Leu Glu Leu Glu Asp Gly Asp Asn Pro 
    290                 295                 300                 


Tyr Pro Ser Lys Glu Asp Xaa Pro Xaa Ser Ser Leu Asp Ser Leu Ser 
305                 310                 315                 320 


Ser Pro Ser Pro Val Xaa Xaa Ala Val Pro Gly Pro Pro Gly Pro Asp 
                325                 330                 335     


Lys Asn His Leu Leu Ala Asp Gly Gly Ser Phe Gly Asp Trp Ala Ser 
            340                 345                 350         


Xaa Ile Ile Arg Ser Arg Lys Ala Arg Ala Val Tyr Pro Cys Glu Ala 
        355                 360                 365             


Glu His Ser Ser Glu Leu Ser Phe Glu Ile Gly Ala Ile Phe Glu Asp 
    370                 375                 380                 


Val Gln Xaa Ser Arg Glu Pro Gly Trp Leu Glu Gly Xaa Leu Asn Gly 
385                 390                 395                 400 


Lys Arg Gly Leu Ile Pro Gln Asn Tyr Val Lys Leu Leu 
                405                 410             


<210> 2711
<211> 834
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<400> 2711
Met Asp Ser Ser Asn Leu Ala Val Ile Phe Ala Pro Asn Leu Leu Gln 
1               5                   10                  15      


Xaa Ser Glu Gly His Glu Lys Met Ser Ser Asn Xaa Glu Lys Lys Leu 
            20                  25                  30          


Arg Leu Gln Ala Ala Val Val Gln Xaa Leu Ile Asp Tyr Ala Ser Asp 
        35                  40                  45              


Ile Gly Arg Val Pro Asp Phe Ile Leu Glu Lys Ile Pro Ala Met Leu 
    50                  55                  60                  


Gly Ile Asp Gly Leu Cys Ala Xaa Pro Ser Leu Glu Gly Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Tyr Glu Xaa Pro Gly Glu Tyr Lys Arg Lys Arg Arg Gln Ser 
                85                  90                  95      


Val Gly Asp Phe Val Ser Gly Ala Leu Asn Lys Phe Lys Pro Asn Arg 
            100                 105                 110         


Xaa Pro Ser Ile Xaa Pro Gln Glu Glu Arg Ile Ala Gln Leu Ser Glu 
        115                 120                 125             


Ser Pro Val Ile Leu Xaa Pro Asn Ala Lys Arg Xaa Leu Pro Val Asp 
    130                 135                 140                 


Ser Ser His Gly Phe Ser Ser Lys Lys Arg Lys Ser Ile Lys His Asn 
145                 150                 155                 160 


Phe Asn Phe Glu Leu Leu Pro Ser Asn Leu Phe Asn Ser Ser Ser Xaa 
                165                 170                 175     


Pro Val Ser Val His Ile Asp Xaa Ser Ser Glu Gly Ser Ser Gln Ser 
            180                 185                 190         


Ser Leu Ser Pro Val Leu Ile Gly Gly Asn His Leu Ile Xaa Ala Gly 
        195                 200                 205             


Val Pro Arg Arg Ser Lys Arg Ile Ala Gly Lys Lys Val Cys Arg Val 
    210                 215                 220                 


Glu Ser Gly Lys Ala Gly Cys Phe Ser Pro Lys Ile Ser His Lys Glu 
225                 230                 235                 240 


Lys Val Arg Arg Ser Leu Arg Leu Lys Phe Asn Leu Gly Lys Asn Gly 
                245                 250                 255     


Arg Glu Val Asn Gly Cys Ser Gly Val Asn Arg Tyr Glu Ser Val Gly 
            260                 265                 270         


Trp Arg Leu Ala Asn Gln Gln Ser Leu Lys Asn Arg Ile Glu Ser Val 
        275                 280                 285             


Lys Xaa Gly Leu Leu Phe Ser Pro Asp Val Asp Glu Lys Leu Pro Lys 
    290                 295                 300                 


Lys Gly Ser Glu Lys Ile Ser Lys Ser Glu Glu Xaa Leu Leu Xaa Pro 
305                 310                 315                 320 


Glu Arg Leu Val Gly Xaa Asn Tyr Arg Met Ser Trp Xaa Gly Pro Asn 
                325                 330                 335     


Asn Ser Ser Phe Gln Glu Val Asp Ala Asn Glu Ala Ser Ser Met Val 
            340                 345                 350         


Glu Asn Leu Glu Val Glu Asn Ser Leu Glu Pro Asp Ile Met Val Glu 
        355                 360                 365             


Lys Ser Pro Ala Xaa Ser Cys Glu Leu Xaa Pro Ser Asn Leu Asn Asn 
    370                 375                 380                 


Lys His Asn Ser Asn Ile Xaa Ser Ser Pro Leu Ser Gly Asp Glu Asn 
385                 390                 395                 400 


Asn Met Xaa Lys Glu Xaa Leu Val Lys Val Gln Lys Ala Phe Ser Glu 
                405                 410                 415     


Ser Gly Ser Asn Leu His Ala Leu Met Asn Gln Arg Gln Ser Ser Val 
            420                 425                 430         


Xaa Asn Val Gly Lys Val Lys Leu Xaa Glu Pro Ser Tyr Leu Glu Asp 
        435                 440                 445             


Ser Pro Glu Glu Asn Leu Phe Glu Xaa Asn Asp Leu Xaa Ile Val Glu 
    450                 455                 460                 


Ser Lys Glu Lys Tyr Glu His His Xaa Gly Lys Gly Glu Lys Cys Phe 
465                 470                 475                 480 


Ser Glu Arg Asp Phe Ser Pro Leu Gln Xaa Gln Xaa Phe Asn Arg Glu 
                485                 490                 495     


Xaa Xaa Ile Lys Cys Tyr Ser Xaa Gln Met Lys Met Glu His Glu Lys 
            500                 505                 510         


Asp Ile His Ser Asn Met Pro Lys Asp Tyr Leu Ser Lys Gln Glu Phe 
        515                 520                 525             


Ser Ser Asp Glu Glu Ile Lys Lys Gln Gln Ser Pro Lys Asp Lys Leu 
    530                 535                 540                 


Asn Asn Lys Leu Lys Glu Asn Glu Asn Met Met Glu Gly Asn Leu Pro 
545                 550                 555                 560 


Lys Cys Ala Ala His Ser Lys Asp Glu Ala Arg Ser Ser Phe Ser Gln 
                565                 570                 575     


Gln Ser Xaa Cys Val Val Xaa Asn Leu Ser Lys Pro Arg Pro Met Arg 
            580                 585                 590         


Ile Ala Lys Gln Gln Ser Leu Glu Xaa Cys Glu Lys Xaa Val Ser Glu 
        595                 600                 605             


Ser Ser Gln Met Xaa Glu His Arg Lys Val Ser Asp His Ile Gln Trp 
    610                 615                 620                 


Phe Asn Lys Leu Ser Leu Asn Glu Pro Asn Arg Ile Lys Val Lys Ser 
625                 630                 635                 640 


Pro Leu Lys Phe Gln Arg Xaa Pro Val Arg Gln Ser Val Arg Arg Ile 
                645                 650                 655     


Asn Ser Leu Leu Glu Tyr Ser Arg Gln Pro Xaa Gly His Lys Leu Ala 
            660                 665                 670         


Ser Leu Gly Asp Xaa Ala Ser Pro Leu Val Lys Ser Val Ser Cys Asp 
        675                 680                 685             


Gly Ala Leu Ser Ser Cys Ile Glu Ser Ala Ser Lys Asp Ser Ser Val 
    690                 695                 700                 


Ser Cys Ile Lys Ser Gly Pro Lys Glu Gln Lys Ser Met Ser Cys Glu 
705                 710                 715                 720 


Glu Ser Asn Ile Gly Ala Ile Ser Lys Ser Ser Met Glu Leu Pro Ser 
                725                 730                 735     


Lys Ser Phe Leu Lys Met Arg Lys His Pro Asp Ser Val Asn Ala Ser 
            740                 745                 750         


Leu Arg Ser Xaa Xaa Val Tyr Lys Gln Lys Ile Leu Ser Asp Gly Gln 
        755                 760                 765             


Val Lys Val Pro Leu Asp Asp Leu Xaa Asn His Asp Ile Val Lys Pro 
    770                 775                 780                 


Val Val Asn Asn Asn Met Gly Ile Ser Ser Gly Ile Asn Asn Arg Val 
785                 790                 795                 800 


Leu Arg Arg Pro Ser Glu Arg Gly Arg Ala Trp Tyr Lys Gly Ser Pro 
                805                 810                 815     


Lys His Pro Ile Gly Lys Xaa Gln Leu Leu Pro Xaa Ser Lys Pro Val 
            820                 825                 830         


Asp Leu 
        


<210> 2712
<211> 473
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<400> 2712
Met Trp Asp Gln Arg Leu Val Arg Leu Ala Leu Leu Gln His Leu Arg 
1               5                   10                  15      


Ala Phe Tyr Gly Ile Lys Val Lys Gly Val Arg Gly Gln Cys Asp Arg 
            20                  25                  30          


Arg Arg His Glu Xaa Ala Ala Xaa Glu Ile Gly Gly Lys Ile Phe Gly 
        35                  40                  45              


Val Pro Phe Asn Ala Leu Pro His Ser Ala Val Pro Glu Tyr Gly His 
    50                  55                  60                  


Ile Pro Ser Phe Leu Val Asp Ala Cys Xaa Ser Leu Glu Asp His Ile 
65                  70                  75                  80  


His Xaa Glu Gly Leu Phe Arg Lys Ser Gly Ser Val Ile Arg Leu Lys 
                85                  90                  95      


Ala Leu Lys Asn Lys Val Asp His Gly Glu Gly Cys Leu Ser Ser Ala 
            100                 105                 110         


Pro Pro Cys Asp Ile Ala Gly Leu Leu Lys Gln Phe Phe Arg Glu Leu 
        115                 120                 125             


Pro Glu Pro Ile Leu Pro Ala Asp Leu His Glu Ala Leu Leu Lys Ala 
    130                 135                 140                 


Gln Gln Leu Gly Xaa Glu Glu Lys Asn Lys Ala Xaa Leu Leu Leu Ser 
145                 150                 155                 160 


Cys Leu Leu Ala Asp His Xaa Val His Val Leu Arg Tyr Phe Phe Asn 
                165                 170                 175     


Phe Leu Arg Asn Val Ser Leu Arg Ser Ser Glu Asn Lys Met Asp Ser 
            180                 185                 190         


Ser Asn Leu Ala Val Ile Phe Ala Pro Asn Leu Leu Gln Xaa Ser Glu 
        195                 200                 205             


Gly His Glu Lys Met Ser Ser Asn Xaa Glu Lys Lys Leu Arg Leu Gln 
    210                 215                 220                 


Ala Ala Val Val Gln Xaa Leu Ile Asp Tyr Ala Ser Asp Ile Gly Arg 
225                 230                 235                 240 


Val Pro Asp Phe Ile Leu Glu Lys Ile Pro Ala Met Leu Gly Ile Asp 
                245                 250                 255     


Gly Leu Cys Ala Xaa Pro Ser Leu Glu Gly Phe Glu Glu Gly Glu Tyr 
            260                 265                 270         


Glu Xaa Pro Gly Glu Tyr Lys Arg Lys Arg Arg Gln Ser Val Gly Asp 
        275                 280                 285             


Phe Val Ser Gly Ala Leu Asn Lys Phe Lys Pro Asn Arg Xaa Pro Ser 
    290                 295                 300                 


Ile Xaa Pro Gln Glu Glu Arg Ile Ala Gln Leu Ser Glu Ser Pro Val 
305                 310                 315                 320 


Ile Leu Xaa Pro Asn Ala Lys Arg Xaa Leu Pro Val Asp Ser Ser His 
                325                 330                 335     


Gly Phe Ser Ser Lys Lys Arg Lys Ser Ile Lys His Asn Phe Asn Phe 
            340                 345                 350         


Glu Leu Leu Pro Ser Asn Leu Phe Asn Ser Ser Ser Xaa Pro Val Ser 
        355                 360                 365             


Gly Val Pro Arg Arg Ser Lys Arg Ile Ala Gly Lys Lys Val Cys Arg 
    370                 375                 380                 


Val Glu Ser Gly Lys Ala Gly Cys Phe Ser Pro Lys Ile Ser His Lys 
385                 390                 395                 400 


Glu Lys Val Arg Arg Ser Leu Arg Leu Lys Phe Asn Leu Gly Lys Asn 
                405                 410                 415     


Gly Arg Glu Val Asn Gly Cys Ser Gly Val Asn Arg Tyr Glu Ser Val 
            420                 425                 430         


Gly Trp Arg Leu Ala Asn Gln Gln Ser Leu Lys Asn Arg Ile Glu Ser 
        435                 440                 445             


Val Lys Xaa Gly Leu Leu Phe Ser Pro Asp Val Asp Glu Lys Leu Pro 
    450                 455                 460                 


Lys Lys Gly Xaa Phe Xaa Tyr Tyr Cys 
465                 470             


<210> 2713
<211> 501
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<400> 2713
Met Trp Asp Gln Arg Leu Val Arg Leu Ala Leu Leu Gln His Leu Arg 
1               5                   10                  15      


Ala Phe Tyr Gly Ile Lys Val Lys Gly Val Arg Gly Gln Cys Asp Arg 
            20                  25                  30          


Arg Arg His Glu Xaa Ala Ala Xaa Glu Ile Gly Gly Lys Ile Phe Gly 
        35                  40                  45              


Val Pro Phe Asn Ala Leu Pro His Ser Ala Val Pro Glu Tyr Gly His 
    50                  55                  60                  


Ile Pro Ser Phe Leu Val Asp Ala Cys Xaa Ser Leu Glu Asp His Ile 
65                  70                  75                  80  


His Xaa Glu Gly Leu Phe Arg Lys Ser Gly Ser Val Ile Arg Leu Lys 
                85                  90                  95      


Ala Leu Lys Asn Lys Val Asp His Gly Glu Gly Cys Leu Ser Ser Ala 
            100                 105                 110         


Pro Pro Cys Asp Ile Ala Gly Leu Leu Lys Gln Phe Phe Arg Glu Leu 
        115                 120                 125             


Pro Glu Pro Ile Leu Pro Ala Asp Leu His Glu Ala Leu Leu Lys Ala 
    130                 135                 140                 


Gln Gln Leu Gly Xaa Glu Glu Lys Asn Lys Ala Xaa Leu Leu Leu Ser 
145                 150                 155                 160 


Cys Leu Leu Ala Asp His Xaa Val His Val Leu Arg Tyr Phe Phe Asn 
                165                 170                 175     


Phe Leu Arg Asn Val Ser Leu Arg Ser Ser Glu Asn Lys Met Asp Ser 
            180                 185                 190         


Ser Asn Leu Ala Val Ile Phe Ala Pro Asn Leu Leu Gln Xaa Ser Glu 
        195                 200                 205             


Gly His Glu Lys Met Ser Ser Asn Xaa Glu Lys Lys Leu Arg Leu Gln 
    210                 215                 220                 


Ala Ala Val Val Gln Xaa Leu Ile Asp Tyr Ala Ser Asp Ile Gly Arg 
225                 230                 235                 240 


Val Pro Asp Phe Ile Leu Glu Lys Ile Pro Ala Met Leu Gly Ile Asp 
                245                 250                 255     


Gly Leu Cys Ala Xaa Pro Ser Leu Glu Gly Phe Glu Glu Gly Glu Tyr 
            260                 265                 270         


Glu Xaa Pro Gly Glu Tyr Lys Arg Lys Arg Arg Gln Ser Val Gly Asp 
        275                 280                 285             


Phe Val Ser Gly Ala Leu Asn Lys Phe Lys Pro Asn Arg Xaa Pro Ser 
    290                 295                 300                 


Ile Xaa Pro Gln Glu Glu Arg Ile Ala Gln Leu Ser Glu Ser Pro Val 
305                 310                 315                 320 


Ile Leu Xaa Pro Asn Ala Lys Arg Xaa Leu Pro Val Asp Ser Ser His 
                325                 330                 335     


Gly Phe Ser Ser Lys Lys Arg Lys Ser Ile Lys His Asn Phe Asn Phe 
            340                 345                 350         


Glu Leu Leu Pro Ser Asn Leu Phe Asn Ser Ser Ser Xaa Pro Val Ser 
        355                 360                 365             


Val His Ile Asp Xaa Ser Ser Glu Gly Ser Ser Gln Ser Ser Leu Ser 
    370                 375                 380                 


Pro Val Leu Ile Gly Gly Asn His Leu Ile Xaa Ala Gly Val Pro Arg 
385                 390                 395                 400 


Arg Ser Lys Arg Ile Ala Gly Lys Lys Val Cys Arg Val Glu Ser Gly 
                405                 410                 415     


Lys Ala Gly Cys Phe Ser Pro Lys Ile Ser His Lys Glu Lys Val Arg 
            420                 425                 430         


Arg Ser Leu Arg Leu Lys Phe Asn Leu Gly Lys Asn Gly Arg Glu Val 
        435                 440                 445             


Asn Gly Cys Ser Gly Val Asn Arg Tyr Glu Ser Val Gly Trp Arg Leu 
    450                 455                 460                 


Ala Asn Gln Gln Ser Leu Lys Asn Arg Ile Glu Ser Val Lys Xaa Gly 
465                 470                 475                 480 


Leu Leu Phe Ser Pro Asp Val Asp Glu Lys Leu Pro Lys Lys Gly Xaa 
                485                 490                 495     


Phe Xaa Tyr Tyr Cys 
            500     


<210> 2714
<211> 1023
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1017)..(1017)
<223> Selenocysteine

<400> 2714
Met Trp Asp Gln Arg Leu Val Arg Leu Ala Leu Leu Gln His Leu Arg 
1               5                   10                  15      


Ala Phe Tyr Gly Ile Lys Val Lys Gly Val Arg Gly Gln Cys Asp Arg 
            20                  25                  30          


Arg Arg His Glu Xaa Ala Ala Xaa Glu Ile Gly Gly Lys Ile Phe Gly 
        35                  40                  45              


Val Pro Phe Asn Ala Leu Pro His Ser Ala Val Pro Glu Tyr Gly His 
    50                  55                  60                  


Ile Pro Ser Phe Leu Val Asp Ala Cys Xaa Ser Leu Glu Asp His Ile 
65                  70                  75                  80  


His Xaa Glu Gly Leu Phe Arg Lys Ser Gly Ser Val Ile Arg Leu Lys 
                85                  90                  95      


Ala Leu Lys Asn Lys Val Asp His Gly Glu Gly Cys Leu Ser Ser Ala 
            100                 105                 110         


Pro Pro Cys Asp Ile Ala Gly Leu Leu Lys Gln Phe Phe Arg Glu Leu 
        115                 120                 125             


Pro Glu Pro Ile Leu Pro Ala Asp Leu His Glu Ala Leu Leu Lys Ala 
    130                 135                 140                 


Gln Gln Leu Gly Xaa Glu Glu Lys Asn Lys Ala Xaa Leu Leu Leu Ser 
145                 150                 155                 160 


Cys Leu Leu Ala Asp His Xaa Val His Val Leu Arg Tyr Phe Phe Asn 
                165                 170                 175     


Phe Leu Arg Asn Val Ser Leu Arg Ser Ser Glu Asn Lys Met Asp Ser 
            180                 185                 190         


Ser Asn Leu Ala Val Ile Phe Ala Pro Asn Leu Leu Gln Xaa Ser Glu 
        195                 200                 205             


Gly His Glu Lys Met Ser Ser Asn Xaa Glu Lys Lys Leu Arg Leu Gln 
    210                 215                 220                 


Ala Ala Val Val Gln Xaa Leu Ile Asp Tyr Ala Ser Asp Ile Gly Arg 
225                 230                 235                 240 


Val Pro Asp Phe Ile Leu Glu Lys Ile Pro Ala Met Leu Gly Ile Asp 
                245                 250                 255     


Gly Leu Cys Ala Xaa Pro Ser Leu Glu Gly Phe Glu Glu Gly Glu Tyr 
            260                 265                 270         


Glu Xaa Pro Gly Glu Tyr Lys Arg Lys Arg Arg Gln Ser Val Gly Asp 
        275                 280                 285             


Phe Val Ser Gly Ala Leu Asn Lys Phe Lys Pro Asn Arg Xaa Pro Ser 
    290                 295                 300                 


Ile Xaa Pro Gln Glu Glu Arg Ile Ala Gln Leu Ser Glu Ser Pro Val 
305                 310                 315                 320 


Ile Leu Xaa Pro Asn Ala Lys Arg Xaa Leu Pro Val Asp Ser Ser His 
                325                 330                 335     


Gly Phe Ser Ser Lys Lys Arg Lys Ser Ile Lys His Asn Phe Asn Phe 
            340                 345                 350         


Glu Leu Leu Pro Ser Asn Leu Phe Asn Ser Ser Ser Xaa Pro Val Ser 
        355                 360                 365             


Val His Ile Asp Xaa Ser Ser Glu Gly Ser Ser Gln Ser Ser Leu Ser 
    370                 375                 380                 


Pro Val Leu Ile Gly Gly Asn His Leu Ile Xaa Ala Gly Val Pro Arg 
385                 390                 395                 400 


Arg Ser Lys Arg Ile Ala Gly Lys Lys Val Cys Arg Val Glu Ser Gly 
                405                 410                 415     


Lys Ala Gly Cys Phe Ser Pro Lys Ile Ser His Lys Glu Lys Val Arg 
            420                 425                 430         


Arg Ser Leu Arg Leu Lys Phe Asn Leu Gly Lys Asn Gly Arg Glu Val 
        435                 440                 445             


Asn Gly Cys Ser Gly Val Asn Arg Tyr Glu Ser Val Gly Trp Arg Leu 
    450                 455                 460                 


Ala Asn Gln Gln Ser Leu Lys Asn Arg Ile Glu Ser Val Lys Xaa Gly 
465                 470                 475                 480 


Leu Leu Phe Ser Pro Asp Val Asp Glu Lys Leu Pro Lys Lys Gly Ser 
                485                 490                 495     


Glu Lys Ile Ser Lys Ser Glu Glu Xaa Leu Leu Xaa Pro Glu Arg Leu 
            500                 505                 510         


Val Gly Xaa Asn Tyr Arg Met Ser Trp Xaa Gly Pro Asn Asn Ser Ser 
        515                 520                 525             


Phe Gln Glu Val Asp Ala Asn Glu Ala Ser Ser Met Val Glu Asn Leu 
    530                 535                 540                 


Glu Val Glu Asn Ser Leu Glu Pro Asp Ile Met Val Glu Lys Ser Pro 
545                 550                 555                 560 


Ala Xaa Ser Cys Glu Leu Xaa Pro Ser Asn Leu Asn Asn Lys His Asn 
                565                 570                 575     


Ser Asn Ile Xaa Ser Ser Pro Leu Ser Gly Asp Glu Asn Asn Met Xaa 
            580                 585                 590         


Lys Glu Xaa Leu Val Lys Val Gln Lys Ala Phe Ser Glu Ser Gly Ser 
        595                 600                 605             


Asn Leu His Ala Leu Met Asn Gln Arg Gln Ser Ser Val Xaa Asn Val 
    610                 615                 620                 


Gly Lys Val Lys Leu Xaa Glu Pro Ser Tyr Leu Glu Asp Ser Pro Glu 
625                 630                 635                 640 


Glu Asn Leu Phe Glu Xaa Asn Asp Leu Xaa Ile Val Glu Ser Lys Glu 
                645                 650                 655     


Lys Tyr Glu His His Xaa Gly Lys Gly Glu Lys Cys Phe Ser Glu Arg 
            660                 665                 670         


Asp Phe Ser Pro Leu Gln Xaa Gln Xaa Phe Asn Arg Glu Xaa Xaa Ile 
        675                 680                 685             


Lys Cys Tyr Ser Xaa Gln Met Lys Met Glu His Glu Lys Asp Ile His 
    690                 695                 700                 


Ser Asn Met Pro Lys Asp Tyr Leu Ser Lys Gln Glu Phe Ser Ser Asp 
705                 710                 715                 720 


Glu Glu Ile Lys Lys Gln Gln Ser Pro Lys Asp Lys Leu Asn Asn Lys 
                725                 730                 735     


Leu Lys Glu Asn Glu Asn Met Met Glu Gly Asn Leu Pro Lys Cys Ala 
            740                 745                 750         


Ala His Ser Lys Asp Glu Ala Arg Ser Ser Phe Ser Gln Gln Ser Xaa 
        755                 760                 765             


Cys Val Val Xaa Asn Leu Ser Lys Pro Arg Pro Met Arg Ile Ala Lys 
    770                 775                 780                 


Gln Gln Ser Leu Glu Xaa Cys Glu Lys Xaa Val Ser Glu Ser Ser Gln 
785                 790                 795                 800 


Met Xaa Glu His Arg Lys Val Ser Asp His Ile Gln Trp Phe Asn Lys 
                805                 810                 815     


Leu Ser Leu Asn Glu Pro Asn Arg Ile Lys Val Lys Ser Pro Leu Lys 
            820                 825                 830         


Phe Gln Arg Xaa Pro Val Arg Gln Ser Val Arg Arg Ile Asn Ser Leu 
        835                 840                 845             


Leu Glu Tyr Ser Arg Gln Pro Xaa Gly His Lys Leu Ala Ser Leu Gly 
    850                 855                 860                 


Asp Xaa Ala Ser Pro Leu Val Lys Ser Val Ser Cys Asp Gly Ala Leu 
865                 870                 875                 880 


Ser Ser Cys Ile Glu Ser Ala Ser Lys Asp Ser Ser Val Ser Cys Ile 
                885                 890                 895     


Lys Ser Gly Pro Lys Glu Gln Lys Ser Met Ser Cys Glu Glu Ser Asn 
            900                 905                 910         


Ile Gly Ala Ile Ser Lys Ser Ser Met Glu Leu Pro Ser Lys Ser Phe 
        915                 920                 925             


Leu Lys Met Arg Lys His Pro Asp Ser Val Asn Ala Ser Leu Arg Ser 
    930                 935                 940                 


Xaa Xaa Val Tyr Lys Gln Lys Ile Leu Ser Asp Gly Gln Val Lys Val 
945                 950                 955                 960 


Pro Leu Asp Asp Leu Xaa Asn His Asp Ile Val Lys Pro Val Val Asn 
                965                 970                 975     


Asn Asn Met Gly Ile Ser Ser Gly Ile Asn Asn Arg Val Leu Arg Arg 
            980                 985                 990         


Pro Ser Glu Arg Gly Arg Ala Trp  Tyr Lys Gly Ser Pro  Lys His Pro 
        995                 1000                 1005             


Ile Gly  Lys Xaa Gln Leu Leu  Pro Xaa Ser Lys Pro  Val Asp Leu 
    1010                 1015                 1020             


<210> 2715
<211> 207
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<400> 2715
Xaa Phe Val Ser Gly Ala Leu Asn Lys Phe Lys Pro Asn Arg Xaa Pro 
1               5                   10                  15      


Ser Ile Xaa Pro Gln Glu Glu Arg Ile Ala Gln Leu Ser Glu Ser Pro 
            20                  25                  30          


Val Ile Leu Xaa Pro Asn Ala Lys Arg Xaa Leu Pro Val Asp Ser Ser 
        35                  40                  45              


His Gly Phe Ser Ile His Ile Asp Xaa Ser Ser Glu Gly Ser Ser Gln 
    50                  55                  60                  


Ser Ser Leu Ser Pro Val Leu Ile Gly Gly Asn His Leu Ile Xaa Ala 
65                  70                  75                  80  


Gly Val Pro Arg Arg Ser Lys Arg Ile Ala Gly Lys Lys Val Cys Arg 
                85                  90                  95      


Val Glu Ser Gly Lys Ala Gly Cys Phe Ser Pro Lys Ile Ser His Lys 
            100                 105                 110         


Glu Lys Val Arg Arg Ser Leu Arg Leu Lys Phe Asn Leu Gly Lys Asn 
        115                 120                 125             


Gly Arg Glu Val Asn Gly Cys Ser Gly Val Asn Arg Tyr Glu Ser Val 
    130                 135                 140                 


Gly Trp Arg Leu Ala Asn Gln Gln Ser Leu Lys Asn Arg Ile Glu Ser 
145                 150                 155                 160 


Val Lys Xaa Gly Leu Leu Phe Ser Pro Asp Val Asp Glu Lys Leu Pro 
                165                 170                 175     


Lys Lys Gly Ser Glu Lys Ile Ser Lys Ser Glu Glu Xaa Leu Leu Xaa 
            180                 185                 190         


Pro Glu Arg Leu Val Gly Xaa Asn Tyr Arg Met Ser Trp Xaa Gly 
        195                 200                 205         


<210> 2716
<211> 267
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<400> 2716
Met Trp Asp Gln Arg Leu Val Lys Leu Ala Leu Leu Gln His Leu Arg 
1               5                   10                  15      


Ala Phe Tyr Gly Ile Lys Val Lys Gly Val Arg Gly Gln Cys Asp Arg 
            20                  25                  30          


Arg Arg His Glu Xaa Ala Ala Xaa Glu Ile Gly Gly Lys Ile Phe Gly 
        35                  40                  45              


Val Pro Phe Asn Ala Leu Pro His Ser Ala Val Pro Glu Tyr Gly His 
    50                  55                  60                  


Ile Pro Ser Phe Leu Val Asp Ala Cys Xaa Ser Leu Glu Glu His Ile 
65                  70                  75                  80  


His Xaa Glu Gly Leu Phe Arg Lys Ser Gly Ser Val Ile Arg Leu Lys 
                85                  90                  95      


Ala Leu Lys Asn Lys Val Asp His Gly Glu Gly Cys Leu Ser Ser Ala 
            100                 105                 110         


Pro Pro Cys Asp Ile Ala Gly Leu Leu Lys Gln Phe Phe Arg Glu Leu 
        115                 120                 125             


Pro Glu Pro Ile Leu Pro Ala Asp Leu His Glu Ala Leu Leu Lys Ala 
    130                 135                 140                 


Gln Gln Leu Gly Xaa Glu Glu Lys Asn Lys Ala Ile Leu Leu Leu Ser 
145                 150                 155                 160 


Cys Leu Leu Ala Asp His Xaa Val His Val Leu Arg Tyr Phe Phe Asn 
                165                 170                 175     


Phe Leu Arg Asn Val Ser Leu Arg Ser Ser Glu Asn Lys Met Asp Ser 
            180                 185                 190         


Ser Asn Leu Ala Val Ile Phe Ala Pro Asn Leu Leu Gln Xaa Ser Glu 
        195                 200                 205             


Gly His Glu Lys Met Ser Ser Asn Ala Glu Lys Lys Gly Val Tyr Gln 
    210                 215                 220                 


Xaa Leu Ser Trp Lys Arg Tyr Gln Pro Cys Trp Val Leu Met Val Ser 
225                 230                 235                 240 


Val Leu Leu His His Trp Lys Ala Leu Lys Lys Val Asn Met Lys Leu 
                245                 250                 255     


Leu Val Asn Ile Arg Glu Arg Glu Asp Asn Val 
            260                 265         


<210> 2717
<211> 794
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<400> 2717
Met Lys Met Ala Asp Arg Ser Gly Lys Ile Ile Pro Gly Gln Val Tyr 
1               5                   10                  15      


Ile Glu Val Glu Tyr Asp Tyr Glu Tyr Glu Ala Lys Asp Arg Lys Ile 
            20                  25                  30          


Val Ile Lys Gln Gly Glu Arg Tyr Ile Leu Val Lys Lys Xaa Asn Asp 
        35                  40                  45              


Asp Trp Trp Gln Val Lys Pro Asp Glu Asn Ser Lys Ala Phe Tyr Val 
    50                  55                  60                  


Pro Ala Gln Tyr Val Lys Glu Val Xaa Arg Lys Ala Leu Met Pro Pro 
65                  70                  75                  80  


Val Lys Gln Val Ala Gly Leu Pro Asn Asn Ser Xaa Lys Ile Met Gln 
                85                  90                  95      


Ser Leu His Leu Gln Arg Ser Xaa Glu Asn Val Asn Lys Leu Pro Glu 
            100                 105                 110         


Leu Ser Ser Phe Gly Lys Pro Ser Ser Ser Val Gln Gly Xaa Gly Leu 
        115                 120                 125             


Ile Arg Asp Ala Asn Gln Asn Phe Gly Pro Ser Tyr Asn Gln Gly Gln 
    130                 135                 140                 


Xaa Val Asn Leu Ser Leu Asp Leu Xaa His Asn Asn Gly Lys Phe Asn 
145                 150                 155                 160 


Asn Asp Ser His Ser Pro Lys Val Ser Ser Gln Asn Arg Xaa Arg Ser 
                165                 170                 175     


Phe Gly His Phe Pro Gly Pro Glu Phe Leu Asp Val Glu Lys Xaa Ser 
            180                 185                 190         


Phe Ser Gln Glu Gln Ser Cys Asp Ser Ala Gly Glu Gly Ser Glu Arg 
        195                 200                 205             


Ile His Gln Asp Ser Glu Ser Gly Asp Glu Leu Ser Ser Ser Ser Xaa 
    210                 215                 220                 


Glu Gln Ile Arg Ala Xaa Xaa Pro Pro Asn Gln Gly Arg Pro Asp Ser 
225                 230                 235                 240 


Pro Val Tyr Ala Asn Leu Gln Glu Leu Lys Ile Ser Gln Ser Ala Leu 
                245                 250                 255     


Pro Pro Leu Pro Gly Ser Pro Ala Ile Gln Ile Asn Gly Glu Trp Glu 
            260                 265                 270         


Xaa His Lys Asp Ser Ser Gly Arg Cys Tyr Tyr Tyr Asn Arg Gly Xaa 
        275                 280                 285             


Gln Glu Arg Xaa Trp Lys Pro Pro Arg Trp Xaa Arg Asp Ala Ser Ile 
    290                 295                 300                 


Ser Lys Gly Asp Phe Gln Asn Pro Gly Asp Gln Glu Trp Leu Lys His 
305                 310                 315                 320 


Val Asp Asp Gln Gly Arg Gln Tyr Tyr Tyr Ser Ala Asp Gly Ser Arg 
                325                 330                 335     


Ser Glu Trp Glu Leu Pro Lys Tyr Asn Ala Ser Ser Gln Gln Gln Arg 
            340                 345                 350         


Glu Ile Ile Lys Ser Arg Ser Leu Asp Arg Arg Leu Gln Glu Pro Ile 
        355                 360                 365             


Val Leu Xaa Lys Trp Arg His Ser Xaa Ile Val Leu Asp Xaa Asn Asp 
    370                 375                 380                 


Lys Glu Ser Pro Xaa Ala Ser Lys Pro Cys Phe Pro Glu Asn Glu Ser 
385                 390                 395                 400 


Ser Pro Ser Ser Pro Lys His Gln Asp Xaa Asp Gln Glu Lys Tyr Gly 
                405                 410                 415     


Leu Leu Asn Val Xaa Lys Ile Ala Glu Asn Gly Lys Lys Val Arg Lys 
            420                 425                 430         


Asn Trp Leu Ser Ser Trp Ala Val Leu Gln Gly Ser Ser Leu Leu Phe 
        435                 440                 445             


Xaa Lys Xaa Gln Gly Ser Ser Xaa Ser Trp Phe Gly Ser Asn Gln Ser 
    450                 455                 460                 


Lys Pro Glu Phe Xaa Val Asp Leu Lys Gly Ala Xaa Ile Glu Met Ala 
465                 470                 475                 480 


Ser Lys Asp Lys Ser Ser Lys Lys Asn Val Phe Glu Leu Lys Xaa Arg 
                485                 490                 495     


Gln Gly Xaa Glu Leu Leu Ile Gln Ser Asp Asn Asp Xaa Val Ile Asn 
            500                 505                 510         


Asp Trp Phe Lys Val Leu Ser Ser Xaa Ile Asn Asn Gln Ala Val Glu 
        515                 520                 525             


Xaa Asp Glu Gly Ile Glu Glu Glu Ile Pro Asp Ser Pro Gly Ile Glu 
    530                 535                 540                 


Lys His Asp Lys Glu Lys Glu Gln Lys Asp Pro Lys Lys Leu Arg Ser 
545                 550                 555                 560 


Phe Lys Val Ser Ser Ile Asp Ser Ser Glu Gln Lys Lys Xaa Lys Lys 
                565                 570                 575     


Asn Leu Lys Lys Phe Leu Xaa Arg Arg Pro Xaa Leu Gln Ala Val Arg 
            580                 585                 590         


Glu Lys Gly Tyr Ile Lys Asp Gln Val Phe Gly Ser Asn Leu Ala Asn 
        595                 600                 605             


Leu Cys Gln Arg Glu Asn Gly Xaa Val Pro Lys Phe Val Lys Leu Cys 
    610                 615                 620                 


Ile Glu His Val Glu Glu His Gly Leu Asp Ile Asp Gly Ile Tyr Arg 
625                 630                 635                 640 


Val Ser Gly Asn Leu Ala Val Ile Gln Lys Leu Arg Phe Ala Val Asn 
                645                 650                 655     


His Asp Glu Lys Leu Asp Leu Asn Asp Ser Lys Trp Glu Asp Ile His 
            660                 665                 670         


Val Ile Xaa Gly Ala Leu Lys Met Phe Phe Arg Glu Leu Pro Glu Pro 
        675                 680                 685             


Leu Phe Xaa Phe Asn His Phe Asn Asp Phe Val Asn Ala Ile Lys Gln 
    690                 695                 700                 


Glu Pro Arg Gln Arg Val Ala Ala Val Lys Asp Leu Ile Arg Gln Leu 
705                 710                 715                 720 


Pro Lys Pro Asn Gln Asp Xaa Met Gln Ile Leu Phe Arg His Leu Arg 
                725                 730                 735     


Arg Val Ile Glu Asn Gly Glu Lys Asn Arg Met Xaa Tyr Gln Ser Ile 
            740                 745                 750         


Ala Ile Val Phe Gly Pro Xaa Leu Leu Lys Pro Glu Lys Glu Xaa Gly 
        755                 760                 765             


Asn Ile Ala Val His Xaa Val Tyr Gln Asn Gln Ile Val Glu Leu Ile 
    770                 775                 780                 


Leu Leu Glu Leu Ser Ser Ile Phe Gly Arg 
785                 790                 


<210> 2718
<211> 799
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<400> 2718
Met Lys Met Ala Asp Arg Ser Gly Lys Ile Ile Pro Gly Gln Val Tyr 
1               5                   10                  15      


Ile Glu Val Glu Tyr Asp Tyr Glu Tyr Glu Ala Lys Asp Arg Lys Ile 
            20                  25                  30          


Val Ile Lys Gln Gly Glu Arg Tyr Ile Leu Val Lys Lys Xaa Asn Asp 
        35                  40                  45              


Asp Trp Trp Gln Val Lys Pro Asp Glu Asn Ser Lys Ala Phe Tyr Val 
    50                  55                  60                  


Pro Ala Gln Tyr Val Lys Glu Val Xaa Arg Lys Ala Leu Met Pro Pro 
65                  70                  75                  80  


Val Lys Gln Val Ala Gly Leu Pro Asn Asn Ser Xaa Lys Ile Met Gln 
                85                  90                  95      


Ser Leu His Leu Gln Arg Ser Xaa Glu Asn Val Asn Lys Leu Pro Glu 
            100                 105                 110         


Leu Ser Ser Phe Gly Lys Pro Ser Ser Ser Val Gln Gly Xaa Gly Leu 
        115                 120                 125             


Ile Arg Asp Ala Asn Gln Asn Phe Gly Pro Ser Tyr Asn Gln Gly Gln 
    130                 135                 140                 


Xaa Val Asn Leu Ser Leu Asp Leu Xaa His Asn Asn Gly Lys Phe Asn 
145                 150                 155                 160 


Asn Asp Ser His Ser Pro Lys Val Ser Ser Gln Asn Arg Xaa Arg Ser 
                165                 170                 175     


Phe Gly His Phe Pro Gly Pro Glu Phe Leu Asp Val Glu Lys Xaa Ser 
            180                 185                 190         


Phe Ser Gln Glu Gln Ser Cys Asp Ser Ala Gly Glu Gly Ser Glu Arg 
        195                 200                 205             


Ile His Gln Asp Ser Glu Ser Gly Asp Glu Leu Ser Ser Ser Ser Xaa 
    210                 215                 220                 


Glu Gln Ile Arg Ala Xaa Xaa Pro Pro Asn Gln Gly Arg Pro Asp Ser 
225                 230                 235                 240 


Pro Val Tyr Ala Asn Leu Gln Glu Leu Lys Ile Ser Gln Ser Ala Leu 
                245                 250                 255     


Pro Pro Leu Pro Gly Ser Pro Ala Ile Gln Ile Asn Gly Glu Trp Glu 
            260                 265                 270         


Xaa His Lys Asp Ser Ser Gly Arg Cys Tyr Tyr Tyr Asn Arg Gly Xaa 
        275                 280                 285             


Gln Glu Arg Xaa Trp Lys Pro Pro Arg Trp Xaa Arg Asp Ala Ser Ile 
    290                 295                 300                 


Ser Lys Gly Asp Phe Gln Asn Pro Gly Asp Gln Glu Trp Leu Lys His 
305                 310                 315                 320 


Val Asp Asp Gln Gly Arg Gln Tyr Tyr Tyr Ser Ala Asp Gly Ser Arg 
                325                 330                 335     


Ser Glu Trp Glu Leu Pro Lys Tyr Asn Ala Ser Ser Gln Gln Gln Arg 
            340                 345                 350         


Glu Ile Ile Lys Ser Arg Ser Leu Asp Arg Arg Leu Gln Glu Pro Ile 
        355                 360                 365             


Val Leu Xaa Lys Trp Arg His Ser Xaa Ile Val Leu Asp Xaa Asn Asp 
    370                 375                 380                 


Lys Glu Ser Pro Xaa Ala Ser Lys Pro Cys Phe Pro Glu Asn Glu Ser 
385                 390                 395                 400 


Ser Pro Ser Ser Pro Lys His Gln Asp Xaa Ala Ser Ser Pro Lys Asp 
                405                 410                 415     


Gln Glu Lys Tyr Gly Leu Leu Asn Val Xaa Lys Ile Ala Glu Asn Gly 
            420                 425                 430         


Lys Lys Val Arg Lys Asn Trp Leu Ser Ser Trp Ala Val Leu Gln Gly 
        435                 440                 445             


Ser Ser Leu Leu Phe Xaa Lys Xaa Gln Gly Ser Ser Xaa Ser Trp Phe 
    450                 455                 460                 


Gly Ser Asn Gln Ser Lys Pro Glu Phe Xaa Val Asp Leu Lys Gly Ala 
465                 470                 475                 480 


Xaa Ile Glu Met Ala Ser Lys Asp Lys Ser Ser Lys Lys Asn Val Phe 
                485                 490                 495     


Glu Leu Lys Xaa Arg Gln Gly Xaa Glu Leu Leu Ile Gln Ser Asp Asn 
            500                 505                 510         


Asp Xaa Val Ile Asn Asp Trp Phe Lys Val Leu Ser Ser Xaa Ile Asn 
        515                 520                 525             


Asn Gln Ala Val Glu Xaa Asp Glu Gly Ile Glu Glu Glu Ile Pro Asp 
    530                 535                 540                 


Ser Pro Gly Ile Glu Lys His Asp Lys Glu Lys Glu Gln Lys Asp Pro 
545                 550                 555                 560 


Lys Lys Leu Arg Ser Phe Lys Val Ser Ser Ile Asp Ser Ser Glu Gln 
                565                 570                 575     


Lys Lys Xaa Lys Lys Asn Leu Lys Lys Phe Leu Xaa Arg Arg Pro Xaa 
            580                 585                 590         


Leu Gln Ala Val Arg Glu Lys Gly Tyr Ile Lys Asp Gln Val Phe Gly 
        595                 600                 605             


Ser Asn Leu Ala Asn Leu Cys Gln Arg Glu Asn Gly Xaa Val Pro Lys 
    610                 615                 620                 


Phe Val Lys Leu Cys Ile Glu His Val Glu Glu His Gly Leu Asp Ile 
625                 630                 635                 640 


Asp Gly Ile Tyr Arg Val Ser Gly Asn Leu Ala Val Ile Gln Lys Leu 
                645                 650                 655     


Arg Phe Ala Val Asn His Asp Glu Lys Leu Asp Leu Asn Asp Ser Lys 
            660                 665                 670         


Trp Glu Asp Ile His Val Ile Xaa Gly Ala Leu Lys Met Phe Phe Arg 
        675                 680                 685             


Glu Leu Pro Glu Pro Leu Phe Xaa Phe Asn His Phe Asn Asp Phe Val 
    690                 695                 700                 


Asn Ala Ile Lys Gln Glu Pro Arg Gln Arg Val Ala Ala Val Lys Asp 
705                 710                 715                 720 


Leu Ile Arg Gln Leu Pro Lys Pro Asn Gln Asp Xaa Met Gln Ile Leu 
                725                 730                 735     


Phe Arg His Leu Arg Arg Val Ile Glu Asn Gly Glu Lys Asn Arg Met 
            740                 745                 750         


Xaa Tyr Gln Ser Ile Ala Ile Val Phe Gly Pro Xaa Leu Leu Lys Pro 
        755                 760                 765             


Glu Lys Glu Xaa Gly Asn Ile Ala Val His Xaa Val Tyr Gln Asn Gln 
    770                 775                 780                 


Ile Val Glu Leu Ile Leu Leu Glu Leu Ser Ser Ile Phe Gly Arg 
785                 790                 795                 


<210> 2719
<211> 816
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<400> 2719
Met Lys Met Ala Asp Arg Ser Gly Lys Ile Ile Pro Gly Gln Val Tyr 
1               5                   10                  15      


Ile Glu Val Glu Tyr Asp Tyr Glu Tyr Glu Ala Lys Asp Arg Lys Ile 
            20                  25                  30          


Val Ile Lys Gln Gly Glu Arg Tyr Ile Leu Val Lys Lys Xaa Asn Asp 
        35                  40                  45              


Asp Trp Trp Gln Val Lys Pro Asp Glu Asn Ser Lys Ala Phe Tyr Val 
    50                  55                  60                  


Pro Ala Gln Tyr Val Lys Glu Val Xaa Arg Lys Ala Leu Met Pro Pro 
65                  70                  75                  80  


Val Lys Gln Val Ala Gly Leu Pro Asn Asn Ser Xaa Lys Ile Met Gln 
                85                  90                  95      


Ser Leu His Leu Gln Arg Ser Xaa Glu Asn Val Asn Lys Leu Pro Glu 
            100                 105                 110         


Leu Ser Ser Phe Gly Lys Pro Ser Ser Ser Val Gln Gly Xaa Gly Leu 
        115                 120                 125             


Ile Arg Asp Ala Asn Gln Asn Phe Gly Pro Ser Tyr Asn Gln Gly Gln 
    130                 135                 140                 


Xaa Val Asn Leu Ser Leu Asp Leu Xaa His Asn Asn Gly Lys Phe Asn 
145                 150                 155                 160 


Asn Asp Ser His Ser Pro Lys Val Ser Ser Gln Asn Arg Xaa Arg Ser 
                165                 170                 175     


Phe Gly His Phe Pro Gly Pro Glu Phe Leu Asp Val Glu Lys Xaa Ser 
            180                 185                 190         


Phe Ser Gln Glu Gln Ser Cys Asp Ser Ala Gly Glu Gly Ser Glu Arg 
        195                 200                 205             


Ile His Gln Asp Ser Glu Ser Gly Asp Glu Leu Ser Ser Ser Ser Xaa 
    210                 215                 220                 


Glu Gln Ile Arg Ala Xaa Xaa Pro Pro Asn Gln Gly Arg Pro Asp Ser 
225                 230                 235                 240 


Pro Val Tyr Ala Asn Leu Gln Glu Leu Lys Ile Ser Gln Ser Ala Leu 
                245                 250                 255     


Pro Pro Leu Pro Gly Ser Pro Ala Ile Gln Ile Asn Gly Glu Trp Glu 
            260                 265                 270         


Xaa His Lys Asp Ser Ser Gly Arg Cys Tyr Tyr Tyr Asn Arg Gly Xaa 
        275                 280                 285             


Gln Glu Arg Xaa Trp Lys Pro Pro Arg Trp Xaa Arg Asp Ala Ser Ile 
    290                 295                 300                 


Ser Lys Gly Asp Phe Gln Asn Pro Gly Asp Gln Glu Leu Leu Ser Ser 
305                 310                 315                 320 


Glu Glu Asn Tyr Tyr Ser Xaa Ser Tyr Ser Gln Ser Asp Ser Gln Cys 
                325                 330                 335     


Gly Ser Pro Pro Arg Gly Trp Ser Glu Glu Leu Asp Glu Arg Gly His 
            340                 345                 350         


Xaa Leu Tyr Xaa Ser Asp Tyr Xaa Asn Glu Lys Trp Leu Lys His Val 
        355                 360                 365             


Asp Asp Gln Gly Arg Gln Tyr Tyr Tyr Ser Ala Asp Gly Ser Arg Ser 
    370                 375                 380                 


Glu Trp Glu Leu Pro Lys Tyr Asn Ala Ser Ser Gln Gln Gln Arg Glu 
385                 390                 395                 400 


Ile Ile Lys Ser Arg Ser Leu Asp Arg Arg Leu Gln Glu Pro Ile Val 
                405                 410                 415     


Leu Xaa Lys Trp Arg His Ser Xaa Ile Val Leu Asp Xaa Asn Asp Lys 
            420                 425                 430         


Asp Gln Glu Lys Tyr Gly Leu Leu Asn Val Xaa Lys Ile Ala Glu Asn 
        435                 440                 445             


Gly Lys Lys Val Arg Lys Asn Trp Leu Ser Ser Trp Ala Val Leu Gln 
    450                 455                 460                 


Gly Ser Ser Leu Leu Phe Xaa Lys Xaa Gln Gly Ser Ser Xaa Ser Trp 
465                 470                 475                 480 


Phe Gly Ser Asn Gln Ser Lys Pro Glu Phe Xaa Val Asp Leu Lys Gly 
                485                 490                 495     


Ala Xaa Ile Glu Met Ala Ser Lys Asp Lys Ser Ser Lys Lys Asn Val 
            500                 505                 510         


Phe Glu Leu Lys Xaa Arg Gln Gly Xaa Glu Leu Leu Ile Gln Ser Asp 
        515                 520                 525             


Asn Asp Xaa Val Ile Asn Asp Trp Phe Lys Val Leu Ser Ser Xaa Ile 
    530                 535                 540                 


Asn Asn Gln Ala Val Glu Xaa Asp Glu Gly Ile Glu Glu Glu Ile Pro 
545                 550                 555                 560 


Asp Ser Pro Gly Ile Glu Lys His Asp Lys Glu Lys Glu Gln Lys Asp 
                565                 570                 575     


Pro Lys Lys Leu Arg Ser Phe Lys Val Ser Ser Ile Asp Ser Ser Glu 
            580                 585                 590         


Gln Lys Lys Xaa Lys Lys Asn Leu Lys Lys Phe Leu Xaa Arg Arg Pro 
        595                 600                 605             


Xaa Leu Gln Ala Val Arg Glu Lys Gly Tyr Ile Lys Asp Gln Val Phe 
    610                 615                 620                 


Gly Ser Asn Leu Ala Asn Leu Cys Gln Arg Glu Asn Gly Xaa Val Pro 
625                 630                 635                 640 


Lys Phe Val Lys Leu Cys Ile Glu His Val Glu Glu His Gly Leu Asp 
                645                 650                 655     


Ile Asp Gly Ile Tyr Arg Val Ser Gly Asn Leu Ala Val Ile Gln Lys 
            660                 665                 670         


Leu Arg Phe Ala Val Asn His Asp Glu Lys Leu Asp Leu Asn Asp Ser 
        675                 680                 685             


Lys Trp Glu Asp Ile His Val Ile Xaa Gly Ala Leu Lys Met Phe Phe 
    690                 695                 700                 


Arg Glu Leu Pro Glu Pro Leu Phe Xaa Phe Asn His Phe Asn Asp Phe 
705                 710                 715                 720 


Val Asn Ala Ile Lys Gln Glu Pro Arg Gln Arg Val Ala Ala Val Lys 
                725                 730                 735     


Asp Leu Ile Arg Gln Leu Pro Lys Pro Asn Gln Asp Xaa Met Gln Ile 
            740                 745                 750         


Leu Phe Arg His Leu Arg Arg Val Ile Glu Asn Gly Glu Lys Asn Arg 
        755                 760                 765             


Met Xaa Tyr Gln Ser Ile Ala Ile Val Phe Gly Pro Xaa Leu Leu Lys 
    770                 775                 780                 


Pro Glu Lys Glu Xaa Gly Asn Ile Ala Val His Xaa Val Tyr Gln Asn 
785                 790                 795                 800 


Gln Ile Val Glu Leu Ile Leu Leu Glu Leu Ser Ser Ile Phe Gly Arg 
                805                 810                 815     


<210> 2720
<211> 841
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<400> 2720
Met Lys Met Ala Asp Arg Ser Gly Lys Ile Ile Pro Gly Gln Val Tyr 
1               5                   10                  15      


Ile Glu Val Glu Tyr Asp Tyr Glu Tyr Glu Ala Lys Asp Arg Lys Ile 
            20                  25                  30          


Val Ile Lys Gln Gly Glu Arg Tyr Ile Leu Val Lys Lys Xaa Asn Asp 
        35                  40                  45              


Asp Trp Trp Gln Val Lys Pro Asp Glu Asn Ser Lys Ala Phe Tyr Val 
    50                  55                  60                  


Pro Ala Gln Tyr Val Lys Glu Val Xaa Arg Lys Ala Leu Met Pro Pro 
65                  70                  75                  80  


Val Lys Gln Val Ala Gly Leu Pro Asn Asn Ser Xaa Lys Ile Met Gln 
                85                  90                  95      


Ser Leu His Leu Gln Arg Ser Xaa Glu Asn Val Asn Lys Leu Pro Glu 
            100                 105                 110         


Leu Ser Ser Phe Gly Lys Pro Ser Ser Ser Val Gln Gly Xaa Gly Leu 
        115                 120                 125             


Ile Arg Asp Ala Asn Gln Asn Phe Gly Pro Ser Tyr Asn Gln Gly Gln 
    130                 135                 140                 


Xaa Val Asn Leu Ser Leu Asp Leu Xaa His Asn Asn Gly Lys Phe Asn 
145                 150                 155                 160 


Asn Asp Ser His Ser Pro Lys Val Ser Ser Gln Asn Arg Xaa Arg Ser 
                165                 170                 175     


Phe Gly His Phe Pro Gly Pro Glu Phe Leu Asp Val Glu Lys Xaa Ser 
            180                 185                 190         


Phe Ser Gln Glu Gln Ser Cys Asp Ser Ala Gly Glu Gly Ser Glu Arg 
        195                 200                 205             


Ile His Gln Asp Ser Glu Ser Gly Asp Glu Leu Ser Ser Ser Ser Xaa 
    210                 215                 220                 


Glu Gln Ile Arg Ala Xaa Xaa Pro Pro Asn Gln Gly Arg Pro Asp Ser 
225                 230                 235                 240 


Pro Val Tyr Ala Asn Leu Gln Glu Leu Lys Ile Ser Gln Ser Ala Leu 
                245                 250                 255     


Pro Pro Leu Pro Gly Ser Pro Ala Ile Gln Ile Asn Gly Glu Trp Glu 
            260                 265                 270         


Xaa His Lys Asp Ser Ser Gly Arg Cys Tyr Tyr Tyr Asn Arg Gly Xaa 
        275                 280                 285             


Gln Glu Arg Xaa Trp Lys Pro Pro Arg Trp Xaa Arg Asp Ala Ser Ile 
    290                 295                 300                 


Ser Lys Gly Asp Phe Gln Asn Pro Gly Asp Gln Glu Leu Leu Ser Ser 
305                 310                 315                 320 


Glu Glu Asn Tyr Tyr Ser Xaa Ser Tyr Ser Gln Ser Asp Ser Gln Cys 
                325                 330                 335     


Gly Ser Pro Pro Arg Gly Trp Ser Glu Glu Leu Asp Glu Arg Gly His 
            340                 345                 350         


Xaa Leu Tyr Xaa Ser Asp Tyr Xaa Asn Glu Lys Trp Leu Lys His Val 
        355                 360                 365             


Asp Asp Gln Gly Arg Gln Tyr Tyr Tyr Ser Ala Asp Gly Ser Arg Ser 
    370                 375                 380                 


Glu Trp Glu Leu Pro Lys Tyr Asn Ala Ser Ser Gln Gln Gln Arg Glu 
385                 390                 395                 400 


Ile Ile Lys Ser Arg Ser Leu Asp Arg Arg Leu Gln Glu Pro Ile Val 
                405                 410                 415     


Leu Xaa Lys Trp Arg His Ser Xaa Ile Val Leu Asp Xaa Asn Asp Lys 
            420                 425                 430         


Glu Ser Pro Xaa Ala Ser Lys Pro Cys Phe Pro Glu Asn Glu Ser Ser 
        435                 440                 445             


Pro Ser Ser Pro Lys His Gln Asp Xaa Asp Gln Glu Lys Tyr Gly Leu 
    450                 455                 460                 


Leu Asn Val Xaa Lys Ile Ala Glu Asn Gly Lys Lys Val Arg Lys Asn 
465                 470                 475                 480 


Trp Leu Ser Ser Trp Ala Val Leu Gln Gly Ser Ser Leu Leu Phe Xaa 
                485                 490                 495     


Lys Xaa Gln Gly Ser Ser Xaa Ser Trp Phe Gly Ser Asn Gln Ser Lys 
            500                 505                 510         


Pro Glu Phe Xaa Val Asp Leu Lys Gly Ala Xaa Ile Glu Met Ala Ser 
        515                 520                 525             


Lys Asp Lys Ser Ser Lys Lys Asn Val Phe Glu Leu Lys Xaa Arg Gln 
    530                 535                 540                 


Gly Xaa Glu Leu Leu Ile Gln Ser Asp Asn Asp Xaa Val Ile Asn Asp 
545                 550                 555                 560 


Trp Phe Lys Val Leu Ser Ser Xaa Ile Asn Asn Gln Ala Val Glu Xaa 
                565                 570                 575     


Asp Glu Gly Ile Glu Glu Glu Ile Pro Asp Ser Pro Gly Ile Glu Lys 
            580                 585                 590         


His Asp Lys Glu Lys Glu Gln Lys Asp Pro Lys Lys Leu Arg Ser Phe 
        595                 600                 605             


Lys Val Ser Ser Ile Asp Ser Ser Glu Gln Lys Lys Xaa Lys Lys Asn 
    610                 615                 620                 


Leu Lys Lys Phe Leu Xaa Arg Arg Pro Xaa Leu Gln Ala Val Arg Glu 
625                 630                 635                 640 


Lys Gly Tyr Ile Lys Asp Gln Val Phe Gly Ser Asn Leu Ala Asn Leu 
                645                 650                 655     


Cys Gln Arg Glu Asn Gly Xaa Val Pro Lys Phe Val Lys Leu Cys Ile 
            660                 665                 670         


Glu His Val Glu Glu His Gly Leu Asp Ile Asp Gly Ile Tyr Arg Val 
        675                 680                 685             


Ser Gly Asn Leu Ala Val Ile Gln Lys Leu Arg Phe Ala Val Asn His 
    690                 695                 700                 


Asp Glu Lys Leu Asp Leu Asn Asp Ser Lys Trp Glu Asp Ile His Val 
705                 710                 715                 720 


Ile Xaa Gly Ala Leu Lys Met Phe Phe Arg Glu Leu Pro Glu Pro Leu 
                725                 730                 735     


Phe Xaa Phe Asn His Phe Asn Asp Phe Val Asn Ala Ile Lys Gln Glu 
            740                 745                 750         


Pro Arg Gln Arg Val Ala Ala Val Lys Asp Leu Ile Arg Gln Leu Pro 
        755                 760                 765             


Lys Pro Asn Gln Asp Xaa Met Gln Ile Leu Phe Arg His Leu Arg Arg 
    770                 775                 780                 


Val Ile Glu Asn Gly Glu Lys Asn Arg Met Xaa Tyr Gln Ser Ile Ala 
785                 790                 795                 800 


Ile Val Phe Gly Pro Xaa Leu Leu Lys Pro Glu Lys Glu Xaa Gly Asn 
                805                 810                 815     


Ile Ala Val His Xaa Val Tyr Gln Asn Gln Ile Val Glu Leu Ile Leu 
            820                 825                 830         


Leu Glu Leu Ser Ser Ile Phe Gly Arg 
        835                 840     


<210> 2721
<211> 846
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<400> 2721
Met Lys Met Ala Asp Arg Ser Gly Lys Ile Ile Pro Gly Gln Val Tyr 
1               5                   10                  15      


Ile Glu Val Glu Tyr Asp Tyr Glu Tyr Glu Ala Lys Asp Arg Lys Ile 
            20                  25                  30          


Val Ile Lys Gln Gly Glu Arg Tyr Ile Leu Val Lys Lys Xaa Asn Asp 
        35                  40                  45              


Asp Trp Trp Gln Val Lys Pro Asp Glu Asn Ser Lys Ala Phe Tyr Val 
    50                  55                  60                  


Pro Ala Gln Tyr Val Lys Glu Val Xaa Arg Lys Ala Leu Met Pro Pro 
65                  70                  75                  80  


Val Lys Gln Val Ala Gly Leu Pro Asn Asn Ser Xaa Lys Ile Met Gln 
                85                  90                  95      


Ser Leu His Leu Gln Arg Ser Xaa Glu Asn Val Asn Lys Leu Pro Glu 
            100                 105                 110         


Leu Ser Ser Phe Gly Lys Pro Ser Ser Ser Val Gln Gly Xaa Gly Leu 
        115                 120                 125             


Ile Arg Asp Ala Asn Gln Asn Phe Gly Pro Ser Tyr Asn Gln Gly Gln 
    130                 135                 140                 


Xaa Val Asn Leu Ser Leu Asp Leu Xaa His Asn Asn Gly Lys Phe Asn 
145                 150                 155                 160 


Asn Asp Ser His Ser Pro Lys Val Ser Ser Gln Asn Arg Xaa Arg Ser 
                165                 170                 175     


Phe Gly His Phe Pro Gly Pro Glu Phe Leu Asp Val Glu Lys Xaa Ser 
            180                 185                 190         


Phe Ser Gln Glu Gln Ser Cys Asp Ser Ala Gly Glu Gly Ser Glu Arg 
        195                 200                 205             


Ile His Gln Asp Ser Glu Ser Gly Asp Glu Leu Ser Ser Ser Ser Xaa 
    210                 215                 220                 


Glu Gln Ile Arg Ala Xaa Xaa Pro Pro Asn Gln Gly Arg Pro Asp Ser 
225                 230                 235                 240 


Pro Val Tyr Ala Asn Leu Gln Glu Leu Lys Ile Ser Gln Ser Ala Leu 
                245                 250                 255     


Pro Pro Leu Pro Gly Ser Pro Ala Ile Gln Ile Asn Gly Glu Trp Glu 
            260                 265                 270         


Xaa His Lys Asp Ser Ser Gly Arg Cys Tyr Tyr Tyr Asn Arg Gly Xaa 
        275                 280                 285             


Gln Glu Arg Xaa Trp Lys Pro Pro Arg Trp Xaa Arg Asp Ala Ser Ile 
    290                 295                 300                 


Ser Lys Gly Asp Phe Gln Asn Pro Gly Asp Gln Glu Leu Leu Ser Ser 
305                 310                 315                 320 


Glu Glu Asn Tyr Tyr Ser Xaa Ser Tyr Ser Gln Ser Asp Ser Gln Cys 
                325                 330                 335     


Gly Ser Pro Pro Arg Gly Trp Ser Glu Glu Leu Asp Glu Arg Gly His 
            340                 345                 350         


Xaa Leu Tyr Xaa Ser Asp Tyr Xaa Asn Glu Lys Trp Leu Lys His Val 
        355                 360                 365             


Asp Asp Gln Gly Arg Gln Tyr Tyr Tyr Ser Ala Asp Gly Ser Arg Ser 
    370                 375                 380                 


Glu Trp Glu Leu Pro Lys Tyr Asn Ala Ser Ser Gln Gln Gln Arg Glu 
385                 390                 395                 400 


Ile Ile Lys Ser Arg Ser Leu Asp Arg Arg Leu Gln Glu Pro Ile Val 
                405                 410                 415     


Leu Xaa Lys Trp Arg His Ser Xaa Ile Val Leu Asp Xaa Asn Asp Lys 
            420                 425                 430         


Glu Ser Pro Xaa Ala Ser Lys Pro Cys Phe Pro Glu Asn Glu Ser Ser 
        435                 440                 445             


Pro Ser Ser Pro Lys His Gln Asp Xaa Ala Ser Ser Pro Lys Asp Gln 
    450                 455                 460                 


Glu Lys Tyr Gly Leu Leu Asn Val Xaa Lys Ile Ala Glu Asn Gly Lys 
465                 470                 475                 480 


Lys Val Arg Lys Asn Trp Leu Ser Ser Trp Ala Val Leu Gln Gly Ser 
                485                 490                 495     


Ser Leu Leu Phe Xaa Lys Xaa Gln Gly Ser Ser Xaa Ser Trp Phe Gly 
            500                 505                 510         


Ser Asn Gln Ser Lys Pro Glu Phe Xaa Val Asp Leu Lys Gly Ala Xaa 
        515                 520                 525             


Ile Glu Met Ala Ser Lys Asp Lys Ser Ser Lys Lys Asn Val Phe Glu 
    530                 535                 540                 


Leu Lys Xaa Arg Gln Gly Xaa Glu Leu Leu Ile Gln Ser Asp Asn Asp 
545                 550                 555                 560 


Xaa Val Ile Asn Asp Trp Phe Lys Val Leu Ser Ser Xaa Ile Asn Asn 
                565                 570                 575     


Gln Ala Val Glu Xaa Asp Glu Gly Ile Glu Glu Glu Ile Pro Asp Ser 
            580                 585                 590         


Pro Gly Ile Glu Lys His Asp Lys Glu Lys Glu Gln Lys Asp Pro Lys 
        595                 600                 605             


Lys Leu Arg Ser Phe Lys Val Ser Ser Ile Asp Ser Ser Glu Gln Lys 
    610                 615                 620                 


Lys Xaa Lys Lys Asn Leu Lys Lys Phe Leu Xaa Arg Arg Pro Xaa Leu 
625                 630                 635                 640 


Gln Ala Val Arg Glu Lys Gly Tyr Ile Lys Asp Gln Val Phe Gly Ser 
                645                 650                 655     


Asn Leu Ala Asn Leu Cys Gln Arg Glu Asn Gly Xaa Val Pro Lys Phe 
            660                 665                 670         


Val Lys Leu Cys Ile Glu His Val Glu Glu His Gly Leu Asp Ile Asp 
        675                 680                 685             


Gly Ile Tyr Arg Val Ser Gly Asn Leu Ala Val Ile Gln Lys Leu Arg 
    690                 695                 700                 


Phe Ala Val Asn His Asp Glu Lys Leu Asp Leu Asn Asp Ser Lys Trp 
705                 710                 715                 720 


Glu Asp Ile His Val Ile Xaa Gly Ala Leu Lys Met Phe Phe Arg Glu 
                725                 730                 735     


Leu Pro Glu Pro Leu Phe Xaa Phe Asn His Phe Asn Asp Phe Val Asn 
            740                 745                 750         


Ala Ile Lys Gln Glu Pro Arg Gln Arg Val Ala Ala Val Lys Asp Leu 
        755                 760                 765             


Ile Arg Gln Leu Pro Lys Pro Asn Gln Asp Xaa Met Gln Ile Leu Phe 
    770                 775                 780                 


Arg His Leu Arg Arg Val Ile Glu Asn Gly Glu Lys Asn Arg Met Xaa 
785                 790                 795                 800 


Tyr Gln Ser Ile Ala Ile Val Phe Gly Pro Xaa Leu Leu Lys Pro Glu 
                805                 810                 815     


Lys Glu Xaa Gly Asn Ile Ala Val His Xaa Val Tyr Gln Asn Gln Ile 
            820                 825                 830         


Val Glu Leu Ile Leu Leu Glu Leu Ser Ser Ile Phe Gly Arg 
        835                 840                 845     


<210> 2722
<211> 196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<400> 2722
Xaa Ser Xaa Ser Tyr Ser Gln Ser Asp Ser Gln Cys Gly Ser Pro Pro 
1               5                   10                  15      


Arg Gly Trp Ser Glu Glu Leu Asp Glu Arg Gly His Xaa Leu Tyr Xaa 
            20                  25                  30          


Ser Asp Tyr Xaa Asn Glu Lys Trp Leu Lys His Val Asp Asp Gln Gly 
        35                  40                  45              


Arg Gln Tyr Tyr Tyr Ser Ala Asp Gly Ser Arg Ser Glu Trp Glu Leu 
    50                  55                  60                  


Pro Lys Tyr Asn Ala Ser Ser Gln Gln Gln Arg Glu Ile Ile Lys Ser 
65                  70                  75                  80  


Arg Ser Leu Asp Arg Arg Leu Gln Glu Pro Ile Val Leu Xaa Lys Trp 
                85                  90                  95      


Arg His Ser Xaa Ile Val Leu Asp Xaa Asn Asp Lys Glu Ser Pro Xaa 
            100                 105                 110         


Ala Ser Lys Pro Cys Phe Pro Glu Asn Glu Ser Ser Pro Ser Ser Pro 
        115                 120                 125             


Lys His Gln Asp Xaa Asp Gln Glu Lys Tyr Gly Leu Leu Asn Val Xaa 
    130                 135                 140                 


Lys Ile Ala Glu Asn Gly Lys Lys Val Arg Lys Asn Trp Leu Ser Ser 
145                 150                 155                 160 


Trp Ala Val Leu Gln Gly Ser Ser Leu Leu Phe Xaa Lys Xaa Gln Gly 
                165                 170                 175     


Ser Ser Xaa Ser Trp Phe Gly Ser Asn Gln Ser Lys Pro Glu Phe Xaa 
            180                 185                 190         


Val Asp Leu Lys 
        195     


<210> 2723
<211> 475
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<400> 2723
Met Gln Lys Ser Xaa Asn Ser Asp Xaa Ser Val Glu Xaa Leu Asn Ser 
1               5                   10                  15      


Xaa Arg Gln Gly Xaa Gly Ala Val Gln Met Arg Ile Lys Asn Ala Asn 
            20                  25                  30          


Ser His His Asp Arg Leu Ser Gln Ser Lys Ser Met Ile Leu Xaa Asp 
        35                  40                  45              


Val Gly Lys Val Xaa Glu Pro Ile Ser Arg His Arg Arg Asn His Ser 
    50                  55                  60                  


Gln His Ile Leu Lys Asp Val Ile Pro Pro Leu Glu Gln Leu Met Val 
65                  70                  75                  80  


Glu Lys Glu Gly Tyr Leu Gln Lys Ala Lys Ile Ala Asp Gly Gly Lys 
                85                  90                  95      


Lys Leu Arg Lys Asn Trp Ser Xaa Ser Trp Ile Val Leu Ser Ser Arg 
            100                 105                 110         


Arg Ile Glu Phe Tyr Lys Glu Ser Lys Gln Gln Ala Leu Ser Asn Met 
        115                 120                 125             


Lys Xaa Gly His Lys Pro Glu Ser Val Asp Leu Cys Gly Ala His Ile 
    130                 135                 140                 


Glu Trp Ala Lys Glu Lys Ser Ser Arg Lys Asn Val Phe Gln Ile Xaa 
145                 150                 155                 160 


Xaa Val Ser Gly Asn Glu Phe Leu Leu Gln Ser Asp Ile Asp Phe Ile 
                165                 170                 175     


Ile Leu Asp Trp Phe His Ala Ile Lys Asn Ala Ile Asp Arg Leu Pro 
            180                 185                 190         


Lys Asp Ser Ser Cys Pro Ser Arg Asn Leu Glu Leu Phe Lys Ile Gln 
        195                 200                 205             


Arg Ser Ser Ser Xaa Glu Leu Leu Ser His Tyr Asp Ser Asp Ile Lys 
    210                 215                 220                 


Glu Gln Lys Pro Glu His Arg Lys Ser Leu Met Phe Arg Leu His His 
225                 230                 235                 240 


Ser Ala Ser Asp Xaa Ser Asp Lys Asn Arg Val Lys Ser Arg Leu Lys 
                245                 250                 255     


Lys Phe Ile Xaa Arg Arg Pro Ser Leu Lys Xaa Leu Gln Glu Lys Gly 
            260                 265                 270         


Leu Ile Lys Asp Gln Ile Phe Gly Ser His Leu His Lys Val Cys Glu 
        275                 280                 285             


Arg Glu Asn Ser Xaa Val Pro Trp Phe Val Lys Gln Cys Ile Glu Ala 
    290                 295                 300                 


Val Glu Lys Arg Gly Leu Asp Val Asp Gly Ile Tyr Arg Val Ser Gly 
305                 310                 315                 320 


Asn Leu Ala Xaa Ile Gln Lys Leu Arg Phe Ile Val Asn Gln Glu Glu 
                325                 330                 335     


Lys Leu Asn Leu Asp Asp Ser Gln Trp Glu Asp Ile His Val Val Xaa 
            340                 345                 350         


Gly Ala Leu Lys Met Phe Phe Arg Glu Leu Pro Glu Pro Leu Phe Pro 
        355                 360                 365             


Tyr Ser Phe Phe Glu Gln Phe Val Glu Ala Ile Lys Lys Gln Asp Asn 
    370                 375                 380                 


Asn Xaa Arg Ile Glu Ala Val Lys Ser Leu Val Gln Lys Leu Pro Pro 
385                 390                 395                 400 


Pro Asn Arg Asp Xaa Met Lys Val Leu Phe Gly His Leu Xaa Lys Ile 
                405                 410                 415     


Val Ala Lys Ala Ser Lys Asn Leu Met Ser Xaa Gln Ser Leu Gly Ile 
            420                 425                 430         


Val Phe Gly Pro Xaa Leu Leu Arg Ala Glu Asn Glu Xaa Gly Asn Met 
        435                 440                 445             


Ala Ile His Met Val Tyr Gln Asn Gln Ile Ala Glu Leu Met Leu Ser 
    450                 455                 460                 


Glu Tyr Ser Lys Ile Phe Gly Ser Glu Glu Asp 
465                 470                 475 


<210> 2724
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<400> 2724
Met Gln Lys Ser Xaa Asn Ser Asp Xaa Ser Val Glu Xaa Leu Asn Ser 
1               5                   10                  15      


Xaa Arg Gln Gly Xaa Gly Ala Val Gln Met Arg Ile Lys Asn Ala Asn 
            20                  25                  30          


Ser His His Asp Arg Leu Ser Gln Ser Lys Ser Met Ile Leu Xaa Asp 
        35                  40                  45              


Val Gly Lys Val Xaa Glu Pro Ile Ser Arg His Arg Arg Asn His Ser 
    50                  55                  60                  


Gln His Ile Leu Lys Asp Val Ile Pro Pro Leu Glu Gln Leu Met Val 
65                  70                  75                  80  


Glu Lys Glu Gly Tyr Leu Gln Lys Ala Lys Ile Ala Asp Gly Gly Lys 
                85                  90                  95      


Lys Leu Arg Lys Asn Trp Ser Xaa Ser Trp Ile Val Leu Ser Ser Arg 
            100                 105                 110         


Arg Ile Glu Phe Tyr Lys Glu Ser Lys Gln Gln Ala Leu Ser Asn Met 
        115                 120                 125             


Ser Phe Cys Leu Met Cys Ser Gly Gly Xaa 
    130                 135             


<210> 2725
<211> 56
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 2725
Xaa Leu Asp Val Asp Gly Ile Tyr Arg Val Ser Gly Asn Leu Ala Xaa 
1               5                   10                  15      


Ile Gln Lys Leu Arg Phe Ile Val Asn Gln Val Val Ser Gly Ile Pro 
            20                  25                  30          


Ala Leu Leu Ser Glu Leu Asp Gly Asp Leu Trp Xaa Pro Leu Val Ser 
        35                  40                  45              


Cys Arg Phe Phe Xaa Val Val Ile 
    50                  55      


<210> 2726
<211> 211
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<400> 2726
Met Ala Ala Asp Val Ser Arg Asn Ser Leu Gln Ala His Asp Asn Phe 
1               5                   10                  15      


Leu Ala Glu Lys Xaa Glu Val Leu Ser Glu Asp Leu Leu Gln Ile Glu 
            20                  25                  30          


Arg Arg Leu Asp Xaa Val Arg Ser Ile Cys His His Ser His Lys Arg 
        35                  40                  45              


Leu Val Ala Cys Phe Gln Gly Gln His Gly Xaa Asp Ala Glu Arg Arg 
    50                  55                  60                  


His Lys Lys Leu Pro Leu Xaa Ala Leu Ala Gln Asn Met Gln Glu Ala 
65                  70                  75                  80  


Ser Xaa Gln Leu Glu Asp Ser Leu Leu Gly Lys Met Leu Glu Xaa Cys 
                85                  90                  95      


Gly Asp Ala Glu Asn Gln Leu Ala Leu Glu Leu Ser Gln His Glu Val 
            100                 105                 110         


Phe Val Glu Lys Glu Ile Val Asp Pro Leu Tyr Gly Ile Ala Glu Val 
        115                 120                 125             


Glu Ile Pro Asn Ile Gln Lys Gln Arg Lys Gln Leu Ala Arg Leu Val 
    130                 135                 140                 


Leu Asp Trp Asp Ser Val Arg Ala Arg Trp Asn Gln Ala His Lys Ser 
145                 150                 155                 160 


Ser Gly Xaa Asn Phe Gln Gly Leu Pro Ser Lys Ile Asp Xaa Leu Lys 
                165                 170                 175     


Glu Glu Met Asp Glu Ala Gly Asn Lys Val Glu Gln Cys Lys Asp Gln 
            180                 185                 190         


Leu Ala Ala Asp Met Tyr Asn Phe Met Ala Lys Glu Gly Glu Tyr Gly 
        195                 200                 205             


Lys Phe Phe 
    210     


<210> 2727
<211> 124
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<400> 2727
Met Lys Lys Gln Phe Asn Arg Met Lys Gln Leu Ala Asn Gln Xaa Val 
1               5                   10                  15      


Gly Arg Ala Glu Lys Xaa Glu Val Leu Ser Glu Asp Leu Leu Gln Ile 
            20                  25                  30          


Glu Arg Arg Leu Asp Xaa Val Arg Ser Ile Cys His His Ser His Lys 
        35                  40                  45              


Arg Leu Val Ala Cys Phe Gln Gly Gln His Gly Xaa Asp Ala Glu Arg 
    50                  55                  60                  


Arg His Lys Lys Leu Pro Leu Xaa Ala Leu Ala Gln Asn Met Gln Glu 
65                  70                  75                  80  


Ala Ser Xaa Gln Leu Glu Asp Ser Leu Leu Gly Cys Trp Arg Arg Val 
                85                  90                  95      


Glu Met Leu Arg Ile Ser Trp Leu Ser Ser Ser Pro Ser Xaa Lys Ser 
            100                 105                 110         


Leu Leu Arg Arg Arg Ser Trp Xaa Leu Cys Xaa Ala 
        115                 120                 


<210> 2728
<211> 803
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<400> 2728
Met Lys Lys Gln Phe Asn Arg Met Lys Gln Leu Ala Asn Gln Xaa Val 
1               5                   10                  15      


Gly Arg Ala Glu Lys Xaa Glu Val Leu Ser Glu Asp Leu Leu Gln Ile 
            20                  25                  30          


Glu Arg Arg Leu Asp Xaa Val Arg Ser Ile Cys His His Ser His Lys 
        35                  40                  45              


Arg Leu Val Ala Cys Phe Gln Gly Gln His Gly Xaa Asp Ala Glu Arg 
    50                  55                  60                  


Arg His Lys Lys Leu Pro Leu Xaa Ala Leu Ala Gln Asn Met Gln Glu 
65                  70                  75                  80  


Ala Ser Xaa Gln Leu Glu Asp Ser Leu Leu Gly Lys Met Leu Glu Xaa 
                85                  90                  95      


Cys Gly Asp Ala Glu Asn Gln Leu Ala Leu Glu Leu Ser Gln His Glu 
            100                 105                 110         


Val Phe Val Glu Lys Glu Ile Val Asp Pro Leu Tyr Gly Ile Ala Glu 
        115                 120                 125             


Val Glu Ile Pro Asn Ile Gln Lys Gln Arg Lys Gln Leu Ala Arg Leu 
    130                 135                 140                 


Val Leu Asp Trp Asp Ser Val Arg Ala Arg Trp Asn Gln Ala His Lys 
145                 150                 155                 160 


Ser Ser Gly Xaa Asn Phe Gln Gly Leu Pro Ser Lys Ile Asp Xaa Leu 
                165                 170                 175     


Lys Glu Glu Met Asp Glu Ala Gly Asn Lys Val Glu Gln Cys Lys Asp 
            180                 185                 190         


Gln Leu Ala Ala Asp Met Tyr Asn Phe Met Ala Lys Glu Gly Glu Tyr 
        195                 200                 205             


Gly Lys Phe Phe Val Xaa Leu Leu Glu Ala Gln Ala Asp Tyr His Arg 
    210                 215                 220                 


Lys Ala Leu Ala Val Leu Glu Lys Xaa Leu Pro Glu Met Arg Ala His 
225                 230                 235                 240 


Gln Asp Lys Trp Ala Glu Lys Pro Ala Phe Gly Xaa Pro Leu Glu Glu 
                245                 250                 255     


His Leu Lys Arg Ser Gly Arg Glu Ile Ala Leu Pro Ile Glu Ala Cys 
            260                 265                 270         


Val Met Leu Leu Leu Glu Xaa Gly Met Lys Glu Glu Gly Leu Phe Arg 
        275                 280                 285             


Ile Gly Ala Gly Ala Ser Lys Leu Lys Lys Leu Lys Ala Ala Leu Asp 
    290                 295                 300                 


Cys Ser Xaa Ser His Leu Asp Glu Phe Tyr Ser Asp Pro His Ala Val 
305                 310                 315                 320 


Ala Gly Ala Leu Lys Ser Tyr Leu Arg Glu Leu Pro Glu Pro Leu Met 
                325                 330                 335     


Xaa Phe Asn Leu Tyr Glu Glu Trp Xaa Gln Val Ala Ser Val Gln Asp 
            340                 345                 350         


Gln Asp Lys Lys Leu Gln Asp Leu Trp Arg Xaa Cys Gln Lys Leu Pro 
        355                 360                 365             


Pro Gln Asn Phe Val Asn Phe Arg Tyr Leu Ile Lys Phe Leu Ala Lys 
    370                 375                 380                 


Leu Ala Gln Xaa Ser Asp Val Asn Lys Met Xaa Pro Ser Asn Ile Ala 
385                 390                 395                 400 


Ile Val Leu Gly Pro Asn Leu Leu Trp Ala Arg Asn Glu Gly Xaa Leu 
                405                 410                 415     


Ala Glu Met Ala Ala Ala Xaa Ser Val His Val Val Ala Val Ile Glu 
            420                 425                 430         


Pro Ile Ile Gln His Ala Asp Trp Phe Phe Pro Glu Glu Val Glu Phe 
        435                 440                 445             


Asn Val Ser Glu Ala Phe Val Pro Leu Xaa Xaa Pro Ser Ser Asn His 
    450                 455                 460                 


Ser Phe His Xaa Gly Asn Asp Ser Asp Ser Gly Xaa Leu Glu Arg Lys 
465                 470                 475                 480 


Arg Pro Ala Ser Met Ala Val Met Glu Gly Asp Leu Val Lys Lys Glu 
                485                 490                 495     


Ser Pro Pro Lys Pro Lys Asp Pro Val Ser Ala Ala Val Pro Ala Pro 
            500                 505                 510         


Gly Arg Asn Asn Ser Gln Ile Ala Ser Gly Gln Asn Gln Pro Gln Ala 
        515                 520                 525             


Ala Ala Gly Ser His Gln Leu Ser Met Gly Gln Pro His Asn Ala Ala 
    530                 535                 540                 


Gly Pro Ser Pro His Xaa Leu Arg Arg Ala Val Lys Lys Pro Ala Pro 
545                 550                 555                 560 


Ala Pro Pro Lys Pro Gly Asn Pro Pro Pro Gly His Pro Gly Gly Gln 
                565                 570                 575     


Ser Ser Ser Gly Xaa Ser Gln His Pro Pro Ser Leu Ser Pro Lys Pro 
            580                 585                 590         


Pro Xaa Arg Ser Pro Ser Pro Pro Xaa Gln His Xaa Gly Gln Pro Pro 
        595                 600                 605             


Gly Gln Pro Ser Ala Pro Ser Gln Leu Ser Ala Pro Arg Arg Tyr Ser 
    610                 615                 620                 


Ser Ser Leu Ser Pro Ile Gln Ala Pro Asn His Pro Pro Pro Gln Pro 
625                 630                 635                 640 


Pro Xaa Gln Ala Xaa Pro Leu Met His Xaa Lys Pro Asn Ser Gln Gly 
                645                 650                 655     


Pro Pro Asn Pro Met Ala Leu Pro Ser Glu His Gly Leu Glu Gln Pro 
            660                 665                 670         


Ser His Xaa Pro Pro Gln Xaa Pro Xaa Pro Pro Ser Xaa Pro Pro Leu 
        675                 680                 685             


Gly Lys Gln Asn Pro Ser Leu Pro Ala Pro Gln Xaa Leu Ala Gly Gly 
    690                 695                 700                 


Asn Pro Glu Xaa Ala Gln Pro His Ala Gly Xaa Leu Pro Arg Pro Arg 
705                 710                 715                 720 


Pro Val Pro Lys Pro Arg Asn Arg Pro Ser Val Pro Pro Pro Pro Gln 
                725                 730                 735     


Pro Pro Gly Val His Ser Ala Gly Asp Ser Ser Leu Xaa Asn Xaa Ala 
            740                 745                 750         


Pro Xaa Ala Ser Lys Ile Val Xaa Asp Ser Asn Ser Arg Val Ser Glu 
        755                 760                 765             


Pro His Arg Ser Ile Phe Pro Glu Met His Ser Asp Ser Ala Ser Lys 
    770                 775                 780                 


Asp Val Pro Gly Arg Ile Leu Leu Asp Ile Asp Asn Asp Xaa Glu Ser 
785                 790                 795                 800 


Xaa Ala Leu 
            


<210> 2729
<211> 881
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<400> 2729
Met Lys Lys Gln Phe Asn Arg Met Lys Gln Leu Ala Asn Gln Xaa Val 
1               5                   10                  15      


Gly Arg Ala Glu Lys Xaa Glu Val Leu Ser Glu Asp Leu Leu Gln Ile 
            20                  25                  30          


Glu Arg Arg Leu Asp Xaa Val Arg Ser Ile Cys His His Ser His Lys 
        35                  40                  45              


Arg Leu Val Ala Cys Phe Gln Gly Gln His Gly Xaa Asp Ala Glu Arg 
    50                  55                  60                  


Arg His Lys Lys Leu Pro Leu Xaa Ala Leu Ala Gln Asn Met Gln Glu 
65                  70                  75                  80  


Ala Ser Xaa Gln Leu Glu Asp Ser Leu Leu Gly Lys Met Leu Glu Xaa 
                85                  90                  95      


Cys Gly Asp Ala Glu Asn Gln Leu Ala Leu Glu Leu Ser Gln His Glu 
            100                 105                 110         


Val Phe Val Glu Lys Glu Ile Val Asp Pro Leu Tyr Gly Ile Ala Glu 
        115                 120                 125             


Val Glu Ile Pro Asn Ile Gln Lys Gln Arg Lys Gln Leu Ala Arg Leu 
    130                 135                 140                 


Val Leu Asp Trp Asp Ser Val Arg Ala Arg Trp Asn Gln Ala His Lys 
145                 150                 155                 160 


Ser Ser Gly Xaa Asn Phe Gln Gly Leu Pro Ser Lys Ile Asp Xaa Leu 
                165                 170                 175     


Lys Glu Glu Met Asp Glu Ala Gly Asn Lys Val Glu Gln Cys Lys Asp 
            180                 185                 190         


Gln Leu Ala Ala Asp Met Tyr Asn Phe Met Ala Lys Glu Gly Glu Tyr 
        195                 200                 205             


Gly Lys Phe Phe Val Xaa Leu Leu Glu Ala Gln Ala Asp Tyr His Arg 
    210                 215                 220                 


Lys Ala Leu Ala Val Leu Glu Lys Xaa Leu Pro Glu Met Arg Ala His 
225                 230                 235                 240 


Gln Asp Lys Trp Ala Glu Lys Pro Ala Phe Gly Xaa Pro Leu Glu Glu 
                245                 250                 255     


His Leu Lys Arg Ser Gly Arg Glu Ile Ala Leu Pro Ile Glu Ala Cys 
            260                 265                 270         


Val Met Leu Leu Leu Glu Xaa Gly Met Lys Glu Glu Gly Leu Phe Arg 
        275                 280                 285             


Ile Gly Ala Gly Ala Ser Lys Leu Lys Lys Leu Lys Ala Ala Leu Asp 
    290                 295                 300                 


Cys Ser Xaa Ser His Leu Asp Glu Phe Tyr Ser Asp Pro His Ala Val 
305                 310                 315                 320 


Ala Gly Ala Leu Lys Ser Tyr Leu Arg Glu Leu Pro Glu Pro Leu Met 
                325                 330                 335     


Xaa Phe Asn Leu Tyr Glu Glu Trp Xaa Gln Val Ala Ser Val Gln Asp 
            340                 345                 350         


Gln Asp Lys Lys Leu Gln Asp Leu Trp Arg Xaa Cys Gln Lys Leu Pro 
        355                 360                 365             


Pro Gln Asn Phe Val Asn Phe Arg Tyr Leu Ile Lys Phe Leu Ala Lys 
    370                 375                 380                 


Leu Ala Gln Xaa Ser Asp Val Asn Lys Met Xaa Pro Ser Asn Ile Ala 
385                 390                 395                 400 


Ile Val Leu Gly Pro Asn Leu Leu Trp Ala Arg Asn Glu Gly Xaa Leu 
                405                 410                 415     


Ala Glu Met Ala Ala Ala Xaa Ser Val His Val Val Ala Val Ile Glu 
            420                 425                 430         


Pro Ile Ile Gln His Ala Asp Trp Phe Phe Pro Glu Glu Val Glu Phe 
        435                 440                 445             


Asn Val Ser Glu Ala Phe Val Pro Leu Xaa Xaa Pro Ser Ser Asn His 
    450                 455                 460                 


Ser Phe His Xaa Gly Asn Asp Ser Asp Ser Gly Xaa Leu Glu Arg Lys 
465                 470                 475                 480 


Arg Pro Ala Ser Met Ala Val Met Glu Gly Asp Leu Val Lys Lys Glu 
                485                 490                 495     


Ser Phe Gly Val Lys Leu Met Asp Phe Gln Ala His Arg Arg Gly Gly 
            500                 505                 510         


Xaa Leu Asn Arg Lys His Ile Ser Pro Ala Phe Gln Pro Pro Leu Pro 
        515                 520                 525             


Pro Xaa Asp Gly Ser Xaa Val Val Pro Ala Gly Pro Glu Pro Pro Pro 
    530                 535                 540                 


Gln Ser Ser Arg Ala Glu Ser Ser Ser Gly Gly Gly Xaa Val Pro Ser 
545                 550                 555                 560 


Ser Ala Gly Ile Leu Glu Gln Gly Pro Ser Pro Gly Asp Gly Ser Pro 
                565                 570                 575     


Pro Lys Pro Lys Asp Pro Val Ser Ala Ala Val Pro Ala Pro Gly Arg 
            580                 585                 590         


Asn Asn Ser Gln Ile Ala Ser Gly Gln Asn Gln Pro Gln Ala Ala Ala 
        595                 600                 605             


Gly Ser His Gln Leu Ser Met Gly Gln Pro His Asn Ala Ala Gly Pro 
    610                 615                 620                 


Ser Pro His Xaa Leu Arg Arg Ala Val Lys Lys Pro Ala Pro Ala Pro 
625                 630                 635                 640 


Pro Lys Pro Gly Asn Pro Pro Pro Gly His Pro Gly Gly Gln Ser Ser 
                645                 650                 655     


Ser Gly Xaa Ser Gln His Pro Pro Ser Leu Ser Pro Lys Pro Pro Xaa 
            660                 665                 670         


Arg Ser Pro Ser Pro Pro Xaa Gln His Xaa Gly Gln Pro Pro Gly Gln 
        675                 680                 685             


Pro Ser Ala Pro Ser Gln Leu Ser Ala Pro Arg Arg Tyr Ser Ser Ser 
    690                 695                 700                 


Leu Ser Pro Ile Gln Ala Pro Asn His Pro Pro Pro Gln Pro Pro Xaa 
705                 710                 715                 720 


Gln Ala Xaa Pro Leu Met His Xaa Lys Pro Asn Ser Gln Gly Pro Pro 
                725                 730                 735     


Asn Pro Met Ala Leu Pro Ser Glu His Gly Leu Glu Gln Pro Ser His 
            740                 745                 750         


Xaa Pro Pro Gln Xaa Pro Xaa Pro Pro Ser Xaa Pro Pro Leu Gly Lys 
        755                 760                 765             


Gln Asn Pro Ser Leu Pro Ala Pro Gln Xaa Leu Ala Gly Gly Asn Pro 
    770                 775                 780                 


Glu Xaa Ala Gln Pro His Ala Gly Xaa Leu Pro Arg Pro Arg Pro Val 
785                 790                 795                 800 


Pro Lys Pro Arg Asn Arg Pro Ser Val Pro Pro Pro Pro Gln Pro Pro 
                805                 810                 815     


Gly Val His Ser Ala Gly Asp Ser Ser Leu Xaa Asn Xaa Ala Pro Xaa 
            820                 825                 830         


Ala Ser Lys Ile Val Xaa Asp Ser Asn Ser Arg Val Ser Glu Pro His 
        835                 840                 845             


Arg Ser Ile Phe Pro Glu Met His Ser Asp Ser Ala Ser Lys Asp Val 
    850                 855                 860                 


Pro Gly Arg Ile Leu Leu Asp Ile Asp Asn Asp Xaa Glu Ser Xaa Ala 
865                 870                 875                 880 


Leu 
    


<210> 2730
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<400> 2730
Met Lys Lys Gln Phe Asn Arg Met Lys Gln Leu Ala Asn Gln Xaa Val 
1               5                   10                  15      


Gly Arg Ala Glu Lys Xaa Glu Val Leu Ser Glu Asp Leu Leu Gln Ile 
            20                  25                  30          


Glu Arg Arg Leu Asp Xaa Val Arg Ser Ile Cys His His Ser His Lys 
        35                  40                  45              


Arg Leu Val Ala Cys Phe Gln Gly Gln His Gly Xaa Asp Ala Glu Arg 
    50                  55                  60                  


Arg His Val Phe Asn Leu Leu 
65                  70      


<210> 2731
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<400> 2731
Met Gln Glu Ala Ser Xaa Gln Leu Glu Asp Ser Leu Leu Gly Lys Met 
1               5                   10                  15      


Leu Glu Xaa Cys Gly Asp Ala Glu Asn Gln Leu Ala Leu Glu Leu Ser 
            20                  25                  30          


Gln His Glu Val Phe Val Glu Lys Glu Ile Val Asp Pro Leu Tyr Gly 
        35                  40                  45              


Ile Ala Glu Val Glu Ile Pro Asn Ile Gln Lys Gln Arg Lys Gln Leu 
    50                  55                  60                  


Ala Arg Leu Val Leu Asp Trp Asp Ser Val Arg Ala 
65                  70                  75      


<210> 2732
<211> 235
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<400> 2732
Xaa Lys Lys Pro Ala Pro Ala Pro Pro Lys Pro Gly Asn Pro Pro Pro 
1               5                   10                  15      


Gly His Pro Gly Gly Gln Ser Ser Ser Gly Xaa Ser Gln His Pro Pro 
            20                  25                  30          


Ser Leu Ser Pro Lys Pro Pro Xaa Arg Ser Pro Ser Pro Pro Xaa Gln 
        35                  40                  45              


His Xaa Gly Gln Pro Pro Gly Gln Pro Ser Ala Pro Ser Gln Leu Ser 
    50                  55                  60                  


Ala Pro Arg Arg Tyr Ser Ser Ser Leu Ser Pro Ile Gln Ala Pro Asn 
65                  70                  75                  80  


His Pro Pro Pro Gln Pro Pro Xaa Gln Ala Xaa Pro Leu Met His Xaa 
                85                  90                  95      


Lys Pro Asn Ser Gln Gly Pro Pro Asn Pro Met Ala Leu Pro Ser Glu 
            100                 105                 110         


His Gly Leu Glu Gln Pro Ser His Xaa Pro Pro Gln Xaa Pro Xaa Pro 
        115                 120                 125             


Pro Ser Xaa Pro Pro Leu Gly Lys Gln Asn Pro Ser Leu Pro Ala Pro 
    130                 135                 140                 


Gln Xaa Leu Ala Gly Gly Asn Pro Glu Xaa Ala Gln Pro His Ala Gly 
145                 150                 155                 160 


Xaa Leu Pro Arg Pro Arg Pro Val Pro Lys Pro Arg Asn Arg Pro Ser 
                165                 170                 175     


Val Pro Pro Pro Pro Gln Pro Pro Gly Val His Ser Ala Gly Asp Ser 
            180                 185                 190         


Ser Leu Xaa Asn Xaa Ala Pro Xaa Ala Ser Lys Ile Val Xaa Gly Phe 
        195                 200                 205             


Gln Asn Arg Ile Ala Ala Ser Phe Leu Lys Cys Xaa Gln Xaa Gln Pro 
    210                 215                 220                 


Ala Lys Xaa Cys Leu Ala Ala Ser Cys Trp Ile 
225                 230                 235 


<210> 2733
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<400> 2733
Xaa Pro Pro Pro Gln Pro Pro Xaa Gln Ala Xaa Pro Leu Met His Xaa 
1               5                   10                  15      


Lys Pro Asn Ser Gln Gly Pro Pro Asn Pro Met Ala Leu Pro Ser Glu 
            20                  25                  30          


His Gly Leu Glu Gln Pro Ser His Xaa Pro Pro Gln Xaa Pro Xaa Pro 
        35                  40                  45              


Pro Ser Xaa Pro Pro Leu Gly Lys Gln Asn Pro Ser Leu Pro Ala Pro 
    50                  55                  60                  


Gln Xaa Leu Ala Gly Gly Asn Pro Glu Xaa Ala Gln Pro His Ala Gly 
65                  70                  75                  80  


Xaa Leu Pro Arg Pro Arg Pro Val Pro Lys Pro Arg Asn Arg Pro Ser 
                85                  90                  95      


Val Pro Pro Pro Pro Gln Pro Pro Gly Val His Ser Ala Gly Asp Ser 
            100                 105                 110         


Ser Leu Xaa Asn Xaa Ala Pro Xaa Ala Ser Lys Ile Val Xaa Asp Val 
        115                 120                 125             


<210> 2734
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 2734
Xaa Pro Pro Ser Xaa Pro Pro Leu Gly Lys Gln Asn Pro Ser Leu Pro 
1               5                   10                  15      


Ala Pro Gln Xaa Leu Ala Gly Gly Asn Pro Glu Xaa Ala Gln Pro His 
            20                  25                  30          


Ala Gly Xaa Leu Pro Arg Pro Arg Pro Val Pro Lys Pro Arg Asn Arg 
        35                  40                  45              


Pro Ser Val Pro Pro Pro Pro Gln Pro Pro Gly Val His Ser Ala Gly 
    50                  55                  60                  


Asp Ser Ser Leu Xaa Asn Xaa Ala Pro Xaa Ala Ser Lys Ile Val Xaa 
65                  70                  75                  80  


Asp Ala Leu Pro Ser Ala Leu Xaa Gly Gly Glu Gly Phe Gln Asp 
                85                  90                  95  


<210> 2735
<211> 663
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<400> 2735
Met Ser Trp Leu Ser Ser Ser Gln Gly Val Val Leu Xaa Ala Tyr His 
1               5                   10                  15      


Pro Ser Gly Lys Asp Gln Xaa Val Gly Asn Ser His Ala Lys Ala Gly 
            20                  25                  30          


Glu Glu Ala Xaa Ser Ser Arg Arg Tyr Gly Gln Tyr Xaa Met Asn Gln 
        35                  40                  45              


Glu Ser Xaa Xaa Ile Lys Val Met Glu Lys Pro Pro Phe Asp Arg Ser 
    50                  55                  60                  


Ile Ser Gln Asp Ser Leu Asp Glu Leu Ser Met Glu Asp Tyr Trp Ile 
65                  70                  75                  80  


Glu Leu Glu Asn Ile Lys Lys Ser Ser Glu Asn Ser Gln Glu Asp Gln 
                85                  90                  95      


Glu Val Val Val Val Lys Glu Pro Asp Glu Gly Glu Leu Glu Glu Glu 
            100                 105                 110         


Trp Leu Lys Glu Ala Gly Leu Ser Asn Leu Phe Gly Glu Ser Ala Gly 
        115                 120                 125             


Asp Pro Gln Glu Ser Ile Val Phe Leu Ser Xaa Leu Xaa Arg Xaa Gln 
    130                 135                 140                 


Ala Ala Ala Val Gln Lys Arg Val Glu Xaa Val Ser Gln Xaa Leu Arg 
145                 150                 155                 160 


Lys Lys Asn Lys Gln Tyr Gln Ile Pro Asp Val Arg Asp Ile Phe Ala 
                165                 170                 175     


Gln Gln Arg Glu Ser Lys Glu Xaa Ala Pro Gly Gly Xaa Glu Ser Gln 
            180                 185                 190         


Ser Leu Arg Xaa Asn Glu Asn Lys Tyr Gln Gly Arg Asp Asp Glu Ala 
        195                 200                 205             


Ser Asn Leu Val Gly Glu Glu Lys Leu Ile Pro Pro Glu Glu Xaa Pro 
    210                 215                 220                 


Ala Pro Glu Xaa Asp Ile Asn Leu Glu Val Ser Phe Ala Glu Gln Ala 
225                 230                 235                 240 


Leu Asn Gln Lys Glu Ser Ser Lys Glu Lys Ile Gln Lys Ser Lys Gly 
                245                 250                 255     


Asp Asp Ala Xaa Leu Pro Ser Phe Arg Leu Pro Lys Asp Lys Xaa Gly 
            260                 265                 270         


Xaa Xaa Arg Ile Gly Asp Leu Ala Pro Gln Asp Met Lys Lys Val Cys 
        275                 280                 285             


His Leu Ala Leu Ile Glu Leu Xaa Ala Leu Tyr Asp Val Leu Gly Ile 
    290                 295                 300                 


Glu Leu Lys Gln Gln Lys Ala Val Lys Ile Lys Xaa Lys Asp Ser Gly 
305                 310                 315                 320 


Leu Phe Cys Val Pro Leu Xaa Ala Leu Leu Glu Gln Asp Gln Arg Lys 
                325                 330                 335     


Val Pro Gly Met Arg Ile Pro Leu Ile Phe Gln Lys Leu Ile Ser Arg 
            340                 345                 350         


Ile Glu Glu Arg Gly Leu Glu Xaa Glu Gly Leu Leu Arg Ile Pro Gly 
        355                 360                 365             


Ala Ala Ile Arg Ile Lys Asn Leu Cys Gln Glu Leu Glu Ala Lys Phe 
    370                 375                 380                 


Tyr Glu Gly Xaa Phe Asn Trp Glu Ser Val Lys Gln His Asp Ala Ala 
385                 390                 395                 400 


Ser Leu Leu Lys Leu Phe Ile Arg Glu Leu Pro Gln Pro Leu Leu Ser 
                405                 410                 415     


Val Glu Tyr Leu Lys Ala Phe Gln Ala Val Gln Asn Leu Pro Xaa Lys 
            420                 425                 430         


Lys Gln Gln Leu Gln Ala Leu Asn Leu Leu Val Ile Leu Leu Pro Asp 
        435                 440                 445             


Ala Asn Arg Asp Xaa Leu Lys Ala Leu Leu Glu Phe Leu Gln Arg Val 
    450                 455                 460                 


Ile Asp Asn Lys Glu Lys Asn Lys Met Xaa Val Met Asn Val Ala Met 
465                 470                 475                 480 


Val Met Ala Pro Asn Leu Phe Met Cys His Ala Leu Gly Leu Lys Ser 
                485                 490                 495     


Ser Glu Gln Arg Glu Phe Val Met Ala Ala Gly Xaa Ala Asn Xaa Met 
            500                 505                 510         


His Leu Leu Ile Lys Tyr Gln Lys Leu Leu Trp Xaa Ile Pro Lys Phe 
        515                 520                 525             


Ile Val Asn Gln Val Arg Lys Gln Asn Xaa Glu Asn His Lys Lys Asp 
    530                 535                 540                 


Lys Arg Ala Met Lys Lys Leu Leu Lys Lys Met Ala Tyr Asp Arg Glu 
545                 550                 555                 560 


Lys Tyr Glu Lys Gln Asp Lys Ser Xaa Asn Asp Ala Asp Val Pro Gln 
                565                 570                 575     


Gly Val Ile Arg Val Gln Ala Pro His Leu Ser Lys Val Ser Met Ala 
            580                 585                 590         


Ile Gln Leu Xaa Glu Glu Leu Lys Ala Ser Asp Val Leu Ala Arg Phe 
        595                 600                 605             


Leu Ser Gln Glu Ser Gly Val Ala Gln Xaa Leu Lys Lys Gly Glu Val 
    610                 615                 620                 


Phe Leu Tyr Glu Ile Gly Gly Asn Ile Gly Glu Arg Cys Leu Asp Asp 
625                 630                 635                 640 


Asp Xaa Tyr Met Lys Asp Leu Tyr Gln Leu Asn Pro Asn Ala Glu Trp 
                645                 650                 655     


Val Ile Lys Ser Lys Pro Leu 
            660             


<210> 2736
<211> 197
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<400> 2736
Met Ala Xaa Glu Ala Gln Ser Glu Gly Glu Val Pro Ala Arg Glu Ser 
1               5                   10                  15      


Gly Arg Ser Asp Ala Ile Cys Ser Phe Val Ile Cys Asn Asp Ser Ser 
            20                  25                  30          


Leu Arg Glu Lys Gly Val Ile Phe Gly Ser Pro Leu Xaa Glu Glu Gly 
        35                  40                  45              


Ile Ala Gln Ile Tyr Gln Leu Ile Glu Tyr Leu His Lys Asn Leu Arg 
    50                  55                  60                  


Val Glu Gly Leu Phe Arg Val Pro Gly Asn Ser Val Arg Gln Gln Ile 
65                  70                  75                  80  


Leu Arg Asp Ala Leu Asn Asn Gly Xaa Asp Ile Asp Leu Glu Ser Gly 
                85                  90                  95      


Glu Phe His Ser Asn Asp Val Ala Xaa Leu Leu Lys Met Phe Leu Gly 
            100                 105                 110         


Glu Leu Pro Glu Pro Leu Leu Xaa His Lys His Phe Asn Ala His Leu 
        115                 120                 125             


Lys Ile Ala Asp Leu Met Gln Phe Asp Asp Lys Gly Asn Lys Xaa Asn 
    130                 135                 140                 


Ile Pro Asp Lys Asp Arg Gln Ile Glu Ala Leu Gln Leu Leu Phe Leu 
145                 150                 155                 160 


Ile Leu Pro Pro Pro Asn Arg Asn Leu Leu Lys Leu Leu Leu Asp Leu 
                165                 170                 175     


Leu Tyr Gln Xaa Ala Lys Lys Gln Asp Lys Asn Lys Met Ser Ala Tyr 
            180                 185                 190         


Asn Leu Ala Leu Met 
        195         


<210> 2737
<211> 465
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<400> 2737
Met Ala Xaa Glu Ala Gln Ser Glu Gly Glu Val Pro Ala Arg Glu Ser 
1               5                   10                  15      


Gly Arg Ser Asp Ala Ile Cys Ser Phe Val Ile Cys Asn Asp Ser Ser 
            20                  25                  30          


Leu Arg Gly Gln Pro Ile Ile Phe Asn Pro Asp Phe Phe Val Glu Lys 
        35                  40                  45              


Leu Arg His Glu Lys Pro Glu Ile Phe Xaa Glu Leu Val Val Ser Asn 
    50                  55                  60                  


Ile Xaa Arg Leu Ile Asp Leu Pro Gly Xaa Glu Leu Ala Gln Leu Met 
65                  70                  75                  80  


Gly Glu Val Asp Leu Lys Leu Pro Gly Gly Ala Gly Pro Ala Ser Gly 
                85                  90                  95      


Phe Phe Arg Ser Leu Met Ser Leu Lys Arg Lys Glu Lys Gly Val Ile 
            100                 105                 110         


Phe Gly Ser Pro Leu Xaa Glu Glu Gly Ile Ala Gln Ile Tyr Gln Leu 
        115                 120                 125             


Ile Glu Tyr Leu His Lys Asn Leu Arg Val Glu Gly Leu Phe Arg Val 
    130                 135                 140                 


Pro Gly Asn Ser Val Arg Gln Gln Ile Leu Arg Asp Ala Leu Asn Asn 
145                 150                 155                 160 


Gly Xaa Asp Ile Asp Leu Glu Ser Gly Glu Phe His Ser Asn Asp Val 
                165                 170                 175     


Ala Xaa Leu Leu Lys Met Phe Leu Gly Glu Leu Pro Glu Pro Leu Leu 
            180                 185                 190         


Xaa His Lys His Phe Asn Ala His Leu Lys Ile Ala Asp Leu Met Gln 
        195                 200                 205             


Phe Asp Asp Lys Gly Asn Lys Xaa Asn Ile Pro Asp Lys Asp Arg Gln 
    210                 215                 220                 


Ile Glu Ala Leu Gln Leu Leu Phe Leu Ile Leu Pro Pro Pro Asn Arg 
225                 230                 235                 240 


Asn Leu Leu Lys Leu Leu Leu Asp Leu Leu Tyr Gln Xaa Ala Lys Lys 
                245                 250                 255     


Gln Asp Lys Asn Lys Met Ser Ala Tyr Asn Leu Ala Leu Met Phe Ala 
            260                 265                 270         


Pro His Val Leu Trp Pro Lys Asn Ala Pro Ala Tyr Ile Arg Glu Cys 
        275                 280                 285             


Ala Arg Leu His Tyr Leu Gly Ser Arg Xaa Gln Ala Ser Lys Asp Asp 
    290                 295                 300                 


Leu Asp Leu Ile Ala Ser Cys His Xaa Lys Ser Phe Gln Leu Ala Lys 
305                 310                 315                 320 


Ser Gln Lys Arg Asn Arg Val Asp Ser Cys Pro His Gln Glu Glu Xaa 
                325                 330                 335     


Gln His His Xaa Glu Glu Ala Leu Arg Glu Leu Phe Gln His Val His 
            340                 345                 350         


Asp Met Pro Glu Ser Ala Lys Lys Lys Gln Leu Ile Arg Gln Phe Asn 
        355                 360                 365             


Lys Gln Ser Leu Xaa Gln Xaa Pro Gly Arg Glu Pro Ser Xaa Ser Gln 
    370                 375                 380                 


Val Gln Lys Arg Ala Arg Ser Arg Ser Phe Ser Gly Leu Ile Lys Arg 
385                 390                 395                 400 


Lys Val Leu Gly Asn Gln Met Met Ser Glu Lys Lys Lys Lys Asn Pro 
                405                 410                 415     


Xaa Pro Glu Ser Val Ala Ile Gly Glu Leu Lys Gly Xaa Ser Lys Glu 
            420                 425                 430         


Asn Arg Asn Leu Leu Phe Ser Gly Ser Pro Ala Val Xaa Met Xaa Pro 
        435                 440                 445             


Xaa Arg Leu Lys Trp Ser Glu Gly Lys Lys Glu Gly Lys Lys Gly Phe 
    450                 455                 460                 


Leu 
465 


<210> 2738
<211> 494
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<400> 2738
Met Ala Xaa Glu Ala Gln Ser Glu Gly Glu Val Pro Ala Arg Glu Ser 
1               5                   10                  15      


Gly Arg Ser Asp Ala Ile Cys Ser Phe Val Ile Cys Asn Asp Ser Ser 
            20                  25                  30          


Leu Arg Gly Gln Pro Ile Ile Phe Asn Pro Asp Phe Phe Val Glu Lys 
        35                  40                  45              


Leu Arg His Glu Lys Pro Glu Ile Phe Xaa Glu Leu Val Val Ser Asn 
    50                  55                  60                  


Ile Xaa Arg Leu Ile Asp Leu Pro Gly Xaa Glu Leu Ala Gln Leu Met 
65                  70                  75                  80  


Gly Glu Val Asp Leu Lys Leu Pro Gly Gly Ala Gly Pro Ala Ser Gly 
                85                  90                  95      


Phe Phe Arg Ser Leu Met Ser Leu Lys Arg Lys Glu Lys Gly Val Ile 
            100                 105                 110         


Phe Gly Ser Pro Leu Xaa Glu Glu Gly Ile Ala Gln Ile Tyr Gln Leu 
        115                 120                 125             


Ile Glu Tyr Leu His Lys Asn Leu Arg Val Glu Gly Leu Phe Arg Val 
    130                 135                 140                 


Pro Gly Asn Ser Val Arg Gln Gln Ile Leu Arg Asp Ala Leu Asn Asn 
145                 150                 155                 160 


Gly Xaa Asp Ile Asp Leu Glu Ser Gly Glu Phe His Ser Asn Asp Val 
                165                 170                 175     


Ala Xaa Leu Leu Lys Met Phe Leu Gly Glu Leu Pro Glu Pro Leu Leu 
            180                 185                 190         


Xaa His Lys His Phe Asn Ala His Leu Lys Ile Ala Asp Leu Met Gln 
        195                 200                 205             


Phe Asp Asp Lys Gly Asn Lys Xaa Asn Ile Pro Asp Lys Asp Arg Gln 
    210                 215                 220                 


Ile Glu Ala Leu Gln Leu Leu Phe Leu Ile Leu Pro Pro Pro Asn Arg 
225                 230                 235                 240 


Asn Leu Leu Lys Leu Leu Leu Asp Leu Leu Tyr Gln Xaa Ala Lys Lys 
                245                 250                 255     


Gln Asp Lys Asn Lys Met Ser Ala Tyr Asn Leu Ala Leu Met Phe Ala 
            260                 265                 270         


Pro His Val Leu Trp Pro Lys Asn Val Xaa Ala Asn Asp Leu Gln Glu 
        275                 280                 285             


Asn Ile Xaa Lys Leu Asn Ser Gly Met Ala Phe Met Ile Lys His Ser 
    290                 295                 300                 


Gln Lys Leu Phe Lys Ala Pro Ala Tyr Ile Arg Glu Cys Ala Arg Leu 
305                 310                 315                 320 


His Tyr Leu Gly Ser Arg Xaa Gln Ala Ser Lys Asp Asp Leu Asp Leu 
                325                 330                 335     


Ile Ala Ser Cys His Xaa Lys Ser Phe Gln Leu Ala Lys Ser Gln Lys 
            340                 345                 350         


Arg Asn Arg Val Asp Ser Cys Pro His Gln Glu Glu Xaa Gln His His 
        355                 360                 365             


Xaa Glu Glu Ala Leu Arg Glu Leu Phe Gln His Val His Asp Met Pro 
    370                 375                 380                 


Glu Ser Ala Lys Lys Lys Gln Leu Ile Arg Gln Phe Asn Lys Gln Ser 
385                 390                 395                 400 


Leu Xaa Gln Xaa Pro Gly Arg Glu Pro Ser Xaa Ser Gln Val Gln Lys 
                405                 410                 415     


Arg Ala Arg Ser Arg Ser Phe Ser Gly Leu Ile Lys Arg Lys Val Leu 
            420                 425                 430         


Gly Asn Gln Met Met Ser Glu Lys Lys Lys Lys Asn Pro Xaa Pro Glu 
        435                 440                 445             


Ser Val Ala Ile Gly Glu Leu Lys Gly Xaa Ser Lys Glu Asn Arg Asn 
    450                 455                 460                 


Leu Leu Phe Ser Gly Ser Pro Ala Val Xaa Met Xaa Pro Xaa Arg Leu 
465                 470                 475                 480 


Lys Trp Ser Glu Gly Lys Lys Glu Gly Lys Lys Gly Phe Leu 
                485                 490                 


<210> 2739
<211> 485
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<400> 2739
Met Pro His Gln Lys Leu Ser Ala Leu Ile Asp Ala Ile Cys Ser Phe 
1               5                   10                  15      


Val Ile Cys Asn Asp Ser Ser Leu Arg Gly Gln Pro Ile Ile Phe Asn 
            20                  25                  30          


Pro Asp Phe Phe Val Glu Lys Leu Arg His Glu Lys Pro Glu Ile Phe 
        35                  40                  45              


Xaa Glu Leu Val Val Ser Asn Ile Xaa Arg Leu Ile Asp Leu Pro Gly 
    50                  55                  60                  


Xaa Glu Leu Ala Gln Leu Met Gly Glu Val Asp Leu Lys Leu Pro Gly 
65                  70                  75                  80  


Gly Ala Gly Pro Ala Ser Gly Phe Phe Arg Ser Leu Met Ser Leu Lys 
                85                  90                  95      


Arg Lys Glu Lys Gly Val Ile Phe Gly Ser Pro Leu Xaa Glu Glu Gly 
            100                 105                 110         


Ile Ala Gln Ile Tyr Gln Leu Ile Glu Tyr Leu His Lys Asn Leu Arg 
        115                 120                 125             


Val Glu Gly Leu Phe Arg Val Pro Gly Asn Ser Val Arg Gln Gln Ile 
    130                 135                 140                 


Leu Arg Asp Ala Leu Asn Asn Gly Xaa Asp Ile Asp Leu Glu Ser Gly 
145                 150                 155                 160 


Glu Phe His Ser Asn Asp Val Ala Xaa Leu Leu Lys Met Phe Leu Gly 
                165                 170                 175     


Glu Leu Pro Glu Pro Leu Leu Xaa His Lys His Phe Asn Ala His Leu 
            180                 185                 190         


Lys Ile Ala Asp Leu Met Gln Phe Asp Asp Lys Gly Asn Lys Xaa Asn 
        195                 200                 205             


Ile Pro Asp Lys Asp Arg Gln Ile Glu Ala Leu Gln Leu Leu Phe Leu 
    210                 215                 220                 


Ile Leu Pro Pro Pro Asn Arg Asn Leu Leu Lys Leu Leu Leu Asp Leu 
225                 230                 235                 240 


Leu Tyr Gln Xaa Ala Lys Lys Gln Asp Lys Asn Lys Met Ser Ala Tyr 
                245                 250                 255     


Asn Leu Ala Leu Met Phe Ala Pro His Val Leu Trp Pro Lys Asn Val 
            260                 265                 270         


Xaa Ala Asn Asp Leu Gln Glu Asn Ile Xaa Lys Leu Asn Ser Gly Met 
        275                 280                 285             


Ala Phe Met Ile Lys His Ser Gln Lys Leu Phe Lys Ala Pro Ala Tyr 
    290                 295                 300                 


Ile Arg Glu Cys Ala Arg Leu His Tyr Leu Gly Ser Arg Xaa Gln Ala 
305                 310                 315                 320 


Ser Lys Asp Asp Leu Asp Leu Ile Ala Ser Cys His Xaa Lys Ser Phe 
                325                 330                 335     


Gln Leu Ala Lys Ser Gln Lys Arg Asn Arg Val Asp Ser Cys Pro His 
            340                 345                 350         


Gln Glu Glu Xaa Gln His His Xaa Glu Glu Ala Leu Arg Glu Leu Phe 
        355                 360                 365             


Gln His Val His Asp Met Pro Glu Ser Ala Lys Lys Lys Gln Leu Ile 
    370                 375                 380                 


Arg Gln Phe Asn Lys Gln Ser Leu Xaa Gln Xaa Pro Gly Arg Glu Pro 
385                 390                 395                 400 


Ser Xaa Ser Gln Val Gln Lys Arg Ala Arg Ser Arg Ser Phe Ser Gly 
                405                 410                 415     


Leu Ile Lys Arg Lys Val Leu Gly Asn Gln Met Met Ser Glu Lys Lys 
            420                 425                 430         


Lys Lys Asn Pro Xaa Pro Glu Ser Val Ala Ile Gly Glu Leu Lys Gly 
        435                 440                 445             


Xaa Ser Lys Glu Asn Arg Asn Leu Leu Phe Ser Gly Ser Pro Ala Val 
    450                 455                 460                 


Xaa Met Xaa Pro Xaa Arg Leu Lys Trp Ser Glu Gly Lys Lys Glu Gly 
465                 470                 475                 480 


Lys Lys Gly Phe Leu 
                485 


<210> 2740
<211> 300
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(295)
<223> Selenocysteine

<400> 2740
Xaa Xaa Glu Ala Gln Ser Glu Gly Glu Val Pro Ala Arg Glu Ser Gly 
1               5                   10                  15      


Arg Ser Asp Ala Ile Cys Ser Phe Val Ile Cys Asn Asp Ser Ser Leu 
            20                  25                  30          


Arg Gly Gln Pro Ile Ile Phe Asn Pro Asp Phe Phe Val Glu Lys Leu 
        35                  40                  45              


Arg His Glu Lys Pro Glu Ile Phe Xaa Glu Leu Val Val Ser Asn Ile 
    50                  55                  60                  


Xaa Arg Leu Ile Asp Leu Pro Gly Xaa Glu Leu Ala Gln Leu Met Gly 
65                  70                  75                  80  


Glu Val Asp Leu Lys Leu Pro Gly Gly Ala Gly Pro Ala Ser Gly Phe 
                85                  90                  95      


Phe Arg Ser Leu Met Ser Leu Lys Arg Lys Glu Lys Gly Val Ile Phe 
            100                 105                 110         


Gly Ser Pro Leu Xaa Glu Glu Gly Ile Ala Gln Ile Tyr Gln Leu Ile 
        115                 120                 125             


Glu Tyr Leu His Lys Asn Leu Arg Val Glu Gly Leu Phe Arg Val Pro 
    130                 135                 140                 


Gly Asn Ser Val Arg Gln Gln Ile Leu Arg Asp Ala Leu Asn Asn Gly 
145                 150                 155                 160 


Xaa Asp Ile Asp Leu Glu Ser Gly Glu Phe His Ser Asn Asp Val Ala 
                165                 170                 175     


Xaa Leu Leu Lys Met Phe Leu Gly Glu Leu Pro Glu Pro Leu Leu Xaa 
            180                 185                 190         


His Lys His Phe Asn Ala His Leu Lys Ile Ala Asp Leu Met Gln Phe 
        195                 200                 205             


Asp Asp Lys Gly Asn Lys Xaa Asn Ile Pro Asp Lys Asp Arg Gln Ile 
    210                 215                 220                 


Glu Ala Leu Gln Leu Leu Phe Leu Ile Leu Pro Pro Pro Asn Arg Asn 
225                 230                 235                 240 


Leu Leu Lys Leu Leu Leu Asp Leu Leu Tyr Gln Xaa Ala Lys Lys Gln 
                245                 250                 255     


Asp Lys Asn Lys Met Ser Ala Tyr Asn Leu Ala Leu Met Phe Ala Pro 
            260                 265                 270         


His Val Leu Trp Pro Lys Asn Gly Leu Val Leu Leu Pro Xaa Leu Glu 
        275                 280                 285             


Glu Ser Asn Xaa Ile Xaa Xaa His Cys Ser Leu Ile 
    290                 295                 300 


<210> 2741
<211> 731
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<400> 2741
Met Asp Gln Gly Asn Asp Glu Glu Lys Ile Asn Xaa Val Gln Arg Leu 
1               5                   10                  15      


Leu Asp Gln Leu Pro Arg Ala Asn Val Val Leu Leu Arg Tyr Leu Phe 
            20                  25                  30          


Gly Val Leu His Asn Ile Glu Gln His Ser Ser Ser Asn Gln Met Xaa 
        35                  40                  45              


Ala Phe Asn Leu Ala Val Cys Val Ala Pro Ser Ile Leu Trp Pro Pro 
    50                  55                  60                  


Ala Ser Ser Ser Pro Glu Leu Glu Asn Glu Phe Xaa Lys Lys Val Ser 
65                  70                  75                  80  


Leu Leu Ile Gln Phe Leu Ile Glu Asn Cys Leu Arg Ile Phe Gly Glu 
                85                  90                  95      


Glu Ile Xaa Ser Leu Phe Arg Glu Val Ser Val Arg Cys Asp Xaa Arg 
            100                 105                 110         


Glu Asn Ala Ser Asp Ile Ser Cys Phe Gln Leu Asn Asp Ser Ser Tyr 
        115                 120                 125             


Asp Ser Leu Glu Asn Glu Leu Asn Glu Asp Val Asp Ala Pro Cys Ser 
    130                 135                 140                 


Asp Leu Val Lys Lys Leu Gly Gln Gly Ser Arg Ser Met Asp Ser Val 
145                 150                 155                 160 


Leu Xaa Leu Ser Asp Tyr Asp Leu Asp Gln Pro Glu Val Glu Gly Leu 
                165                 170                 175     


Leu Xaa Leu Ser Asp Phe Asp Leu Ala His Ser Lys Asp Glu Asp Val 
            180                 185                 190         


Gln Met Lys Arg Pro Leu Glu Ser Lys Pro Val Asn Ile Leu Val Tyr 
        195                 200                 205             


Xaa Lys Ile Pro Leu Arg Asp His Ala Arg Ala Pro Ser Ala Met Cys 
    210                 215                 220                 


Xaa Pro Ser Tyr Leu Ser Xaa Ala Ala Ala Asn Ala Ala Lys Ser Leu 
225                 230                 235                 240 


Arg Arg His Arg Arg Cys Ser Glu Pro Ser Ile Asp Tyr Leu Asp Ser 
                245                 250                 255     


Lys Leu Ser Tyr Leu Arg Glu Phe Tyr Gln Lys Lys Leu Arg Lys Ser 
            260                 265                 270         


Ser Cys Asp Ala Ile Leu Ser Gln Lys Asp Glu Asp Tyr Leu Lys Gln 
        275                 280                 285             


Asn Gln Pro Leu Gln Glu Glu Gly Lys Xaa Cys Phe Lys Gln Ser Leu 
    290                 295                 300                 


Val Xaa Gly Xaa Asp Val Ser Lys Lys Asn Ala Xaa Xaa Gln Asn Xaa 
305                 310                 315                 320 


Lys Lys Lys Ser Leu Ser Gly Ser Glu Gly Asn His Val Lys Leu Phe 
                325                 330                 335     


Pro Lys Ser Lys Pro Val Ala Ile Ser Val Ala Ser Tyr Ser Pro Met 
            340                 345                 350         


Ser Ser Gln Asp His Ser Lys Asn Gln Pro Phe Asp Val Asn Xaa Ser 
        355                 360                 365             


Gly Tyr Ser Pro Pro His Xaa Ala Asp Ala Leu Lys Gly Pro Arg Xaa 
    370                 375                 380                 


His Arg Arg Cys Ser Glu Pro Asn Ile Glu Asp Gln Asn Arg Lys Leu 
385                 390                 395                 400 


Xaa Tyr Leu Arg Gly Ile Tyr Ser Lys Lys Gln His Lys Xaa Ser Cys 
                405                 410                 415     


Glu Ala Gly Leu Leu His Gly Glu Glu Asp Tyr Leu Lys Arg His Lys 
            420                 425                 430         


Ser Leu Gln Met Glu Gly Gln Lys Leu Ile Asn Gln Ser Leu Val Met 
        435                 440                 445             


Gly Ile Glu Val Gly Lys Ser Ser Ala Xaa Asn Gln Asn Xaa Glu Lys 
    450                 455                 460                 


Val Leu Pro Pro Arg Leu Asn Leu Cys Pro Arg Xaa Ser Tyr Ser Ser 
465                 470                 475                 480 


Leu Ser Ser Pro Gly Xaa Ser Pro Ser Gly Ser Ser Val Ser Ser Gln 
                485                 490                 495     


Asp Ser Ala Phe Ser Gln Ile Ser Glu His Ser Val Phe Xaa Pro Xaa 
            500                 505                 510         


Glu Xaa Ser Ser Pro Ile Asp Cys Xaa Phe Gln Ala Gln Arg Lys Arg 
        515                 520                 525             


Glu Asp Leu Ser Pro Asp Phe Ser Asn Ala Ser His Val Ser Gly Met 
    530                 535                 540                 


Pro Gly Pro Ser Ser Gly Gln Ala Cys Ser Arg Pro Ala Tyr Xaa Lys 
545                 550                 555                 560 


Lys Asp Xaa Met Glu Trp His Ser Gln Met His Ser Val Xaa Leu His 
                565                 570                 575     


Pro Ser Xaa Trp Leu Arg Asn Gly Val Ala Ser Leu Lys Asn Trp Ser 
            580                 585                 590         


Leu Lys Lys Lys Ala Lys Ala Ala Arg Pro Glu Glu Glu Lys Ile Ala 
        595                 600                 605             


Ser Pro Lys Gly Pro Leu Glu Pro Pro Pro His Ala Ser Gly Val Pro 
    610                 615                 620                 


Glu Ala Asn Ser Leu Gln Glu Glu Gln Lys Asp Leu Pro Leu Arg Ala 
625                 630                 635                 640 


Ala Glu Gly Leu Ser Pro Val Gln Ser Ala Gln Arg Cys Ser Ser Ser 
                645                 650                 655     


Pro Phe Gln Asp Ser Glu Arg His Cys Ser Ser Pro Phe Ser Leu Val 
            660                 665                 670         


Glu Ser Arg Leu Lys Leu Cys Met Lys Ser His Glu Glu Ile Glu Pro 
        675                 680                 685             


Gly Ser Gln Ser Ser Ser Gly Ser Leu Pro Trp Glu Arg Ala Ser Ala 
    690                 695                 700                 


Ser Ser Trp Xaa Leu Glu Asp Ala Xaa Ser Pro Asp Ser Gly Pro Xaa 
705                 710                 715                 720 


Val Val Cys Asp Ile Glu Asp Arg Asn Cys Cys 
                725                 730     


<210> 2742
<211> 1191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<400> 2742
Met Glu Ala Met Ser Pro Gln Gln Glu Xaa Leu Gly Gly Gln Pro Gly 
1               5                   10                  15      


Arg Ser Ser Ser Leu Xaa Gly Val Ser Arg Leu Ala Gly Gly Ser Cys 
            20                  25                  30          


Xaa Lys Lys Lys Met Lys Xaa Leu Ala Glu Arg Arg Arg Ser Ala Pro 
        35                  40                  45              


Ser Leu Ile Leu Asp Lys Ala Leu Gln Lys Arg Pro Xaa Xaa Arg Asp 
    50                  55                  60                  


Ser Pro Ser Ala Ser Val Asp Xaa Cys Xaa Phe Leu Ser Ser Leu Val 
65                  70                  75                  80  


Cys Ser Asn Arg Xaa Leu Leu Ile Asp Gly Arg Ala Glu Leu Lys Arg 
                85                  90                  95      


Gly Leu Gln Arg Gln Glu Arg His Leu Phe Leu Phe Asn Asp Leu Phe 
            100                 105                 110         


Val Val Ala Lys Ile Lys Tyr Asn Asn Asn Phe Lys Ile Lys Asn Lys 
        115                 120                 125             


Ile Lys Leu Xaa Asp Met Trp Xaa Ala Ser Cys Val Asp Glu Val Gly 
    130                 135                 140                 


Glu Gly Asn Xaa Asn Ala Met Lys Ser Phe Val Leu Gly Trp Pro Xaa 
145                 150                 155                 160 


Val Asn Phe Val Ala Xaa Phe Ser Ser Pro Glu Gln Lys Asp Lys Trp 
                165                 170                 175     


Leu Ser Leu Leu Gln Arg Tyr Ile Asn Leu Glu Lys Glu Lys Asp Tyr 
            180                 185                 190         


Pro Lys Ser Ile Pro Leu Lys Ile Phe Ala Lys Asp Ile Gly Asn Cys 
        195                 200                 205             


Ala Tyr Ser Lys Xaa Ile Xaa Val Met Asn Ser Asp Xaa Ala Asn Glu 
    210                 215                 220                 


Val Ile Asn Met Ser Leu Pro Met Leu Gly Ile Xaa Gly Ser Glu Arg 
225                 230                 235                 240 


Asp Tyr Gln Leu Trp Val Asn Ser Gly Lys Glu Glu Ala Pro Tyr Pro 
                245                 250                 255     


Leu Ile Gly His Glu Tyr Pro Tyr Gly Ile Lys Met Ser His Leu Arg 
            260                 265                 270         


Asp Ser Ala Leu Leu Xaa Pro Gly Ser Lys Asp Ser Xaa Xaa Pro Phe 
        275                 280                 285             


Asn Leu Gln Glu Pro Phe Leu Met Glu Gln Leu Pro Arg Glu Met Gln 
    290                 295                 300                 


Cys Gln Phe Ile Leu Lys Pro Ser Arg Leu Ala Ala Ala Gln Gln Leu 
305                 310                 315                 320 


Ser Asp Ser Gly His Lys Xaa Phe Lys Arg Arg Arg Ser Ile Ile Asn 
                325                 330                 335     


Trp Ala Phe Trp Arg Gly Ser Ser Xaa His Leu Asp Asn Leu Pro Ser 
            340                 345                 350         


Ser Pro Xaa Ser Pro Met Pro Gly Gln Leu Phe Gly Ile Ser Leu Pro 
        355                 360                 365             


Asn Ile Cys Glu Asn Asp Asn Leu Pro Lys Pro Val Leu Asp Met Leu 
    370                 375                 380                 


Phe Phe Leu Asn Gln Lys Gly Pro Leu Xaa Lys Gly Ile Phe Arg Gln 
385                 390                 395                 400 


Ser Ala Asn Val Lys Ser Cys Arg Glu Leu Lys Glu Lys Leu Asn Ser 
                405                 410                 415     


Gly Val Glu Val His Leu Asp Cys Glu Ser Ile Phe Val Ile Ala Ser 
            420                 425                 430         


Val Leu Lys Asp Phe Leu Arg Asn Ile Pro Gly Ser Ile Phe Ser Ser 
        435                 440                 445             


Asp Leu Tyr Asp His Trp Val Ser Val Met Asp Gln Gly Asn Asp Glu 
    450                 455                 460                 


Glu Lys Ile Asn Xaa Val Gln Arg Leu Leu Asp Gln Leu Pro Arg Ala 
465                 470                 475                 480 


Asn Val Val Leu Leu Arg Tyr Leu Phe Gly Val Leu His Asn Ile Glu 
                485                 490                 495     


Gln His Ser Ser Ser Asn Gln Met Xaa Ala Phe Asn Leu Ala Val Cys 
            500                 505                 510         


Val Ala Pro Ser Ile Leu Trp Pro Pro Ala Ser Ser Ser Pro Glu Leu 
        515                 520                 525             


Glu Asn Glu Phe Xaa Lys Lys Val Ser Leu Leu Ile Gln Phe Leu Ile 
    530                 535                 540                 


Glu Asn Cys Leu Arg Ile Phe Gly Glu Glu Ile Xaa Ser Leu Phe Arg 
545                 550                 555                 560 


Glu Val Ser Val Arg Cys Asp Xaa Arg Glu Asn Ala Ser Asp Ile Ser 
                565                 570                 575     


Cys Phe Gln Leu Asn Asp Ser Ser Tyr Asp Ser Leu Glu Asn Glu Leu 
            580                 585                 590         


Asn Glu Asp Val Asp Ala Pro Cys Ser Asp Leu Val Lys Lys Leu Gly 
        595                 600                 605             


Gln Gly Ser Arg Ser Met Asp Ser Val Leu Xaa Leu Ser Asp Tyr Asp 
    610                 615                 620                 


Leu Asp Gln Pro Glu Val Glu Gly Leu Leu Xaa Leu Ser Asp Phe Asp 
625                 630                 635                 640 


Leu Ala His Ser Lys Asp Glu Asp Val Gln Met Lys Arg Pro Leu Glu 
                645                 650                 655     


Ser Lys Pro Val Asn Ile Leu Val Tyr Xaa Lys Ile Pro Leu Arg Asp 
            660                 665                 670         


His Ala Arg Ala Pro Ser Ala Met Cys Xaa Pro Ser Tyr Leu Ser Xaa 
        675                 680                 685             


Ala Ala Ala Asn Ala Ala Lys Ser Leu Arg Arg His Arg Arg Cys Ser 
    690                 695                 700                 


Glu Pro Ser Ile Asp Tyr Leu Asp Ser Lys Leu Ser Tyr Leu Arg Glu 
705                 710                 715                 720 


Phe Tyr Gln Lys Lys Leu Arg Lys Ser Ser Cys Asp Ala Ile Leu Ser 
                725                 730                 735     


Gln Lys Asp Glu Asp Tyr Leu Lys Gln Asn Gln Pro Leu Gln Glu Glu 
            740                 745                 750         


Gly Lys Xaa Cys Phe Lys Gln Ser Leu Val Xaa Gly Xaa Asp Val Ser 
        755                 760                 765             


Lys Lys Asn Ala Xaa Xaa Gln Asn Xaa Lys Lys Lys Ser Leu Ser Gly 
    770                 775                 780                 


Ser Glu Gly Asn His Val Lys Leu Phe Pro Lys Ser Lys Pro Val Ala 
785                 790                 795                 800 


Ile Ser Val Ala Ser Tyr Ser Pro Met Ser Ser Gln Asp His Ser Lys 
                805                 810                 815     


Asn Gln Pro Phe Asp Val Asn Xaa Ser Gly Tyr Ser Pro Pro His Xaa 
            820                 825                 830         


Ala Asp Ala Leu Lys Gly Pro Arg Xaa His Arg Arg Cys Ser Glu Pro 
        835                 840                 845             


Asn Ile Glu Asp Gln Asn Arg Lys Leu Xaa Tyr Leu Arg Gly Ile Tyr 
    850                 855                 860                 


Ser Lys Lys Gln His Lys Xaa Ser Cys Glu Ala Gly Leu Leu His Gly 
865                 870                 875                 880 


Glu Glu Asp Tyr Leu Lys Arg His Lys Ser Leu Gln Met Glu Gly Gln 
                885                 890                 895     


Lys Leu Ile Asn Gln Ser Leu Val Met Gly Ile Glu Val Gly Lys Ser 
            900                 905                 910         


Ser Ala Xaa Asn Gln Asn Xaa Glu Lys Val Leu Pro Pro Arg Leu Asn 
        915                 920                 925             


Leu Cys Pro Arg Xaa Ser Tyr Ser Ser Leu Ser Ser Pro Gly Xaa Ser 
    930                 935                 940                 


Pro Ser Gly Ser Ser Val Ser Ser Gln Asp Ser Ala Phe Ser Gln Ile 
945                 950                 955                 960 


Ser Glu His Ser Val Phe Xaa Pro Xaa Glu Xaa Ser Ser Pro Ile Asp 
                965                 970                 975     


Cys Xaa Phe Gln Ala Gln Arg Lys Arg Glu Asp Leu Ser Pro Asp Phe 
            980                 985                 990         


Ser Asn Ala Ser His Val Ser Gly  Met Pro Gly Pro Ser  Ser Gly Gln 
        995                 1000                 1005             


Ala Cys  Ser Arg Pro Ala Tyr  Xaa Lys Lys Asp Xaa  Met Glu Trp 
    1010                 1015                 1020             


His Ser  Gln Met His Ser Val  Xaa Leu His Pro Ser  Xaa Trp Leu 
    1025                 1030                 1035             


Arg Asn  Gly Val Ala Ser Leu  Lys Asn Trp Ser Leu  Lys Lys Lys 
    1040                 1045                 1050             


Ala Lys  Ala Ala Arg Pro Glu  Glu Glu Lys Ile Ala  Ser Pro Lys 
    1055                 1060                 1065             


Gly Pro  Leu Glu Pro Pro Pro  His Ala Ser Gly Val  Pro Glu Ala 
    1070                 1075                 1080             


Asn Ser  Leu Gln Glu Glu Gln  Lys Asp Leu Pro Leu  Arg Ala Ala 
    1085                 1090                 1095             


Glu Gly  Leu Ser Pro Val Gln  Ser Ala Gln Arg Cys  Ser Ser Ser 
    1100                 1105                 1110             


Pro Phe  Gln Asp Ser Glu Arg  His Cys Ser Ser Pro  Phe Ser Leu 
    1115                 1120                 1125             


Val Glu  Ser Arg Leu Lys Leu  Cys Met Lys Ser His  Glu Glu Ile 
    1130                 1135                 1140             


Glu Pro  Gly Ser Gln Ser Ser  Ser Gly Ser Leu Pro  Trp Glu Arg 
    1145                 1150                 1155             


Ala Ser  Ala Ser Ser Trp Xaa  Leu Glu Asp Ala Xaa  Ser Pro Asp 
    1160                 1165                 1170             


Ser Gly  Pro Xaa Val Val Cys  Asp Ile Glu Asp Arg  Tyr Leu Xaa 
    1175                 1180                 1185             


Lys Asp  Ile 
    1190     


<210> 2743
<211> 1155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1152)..(1152)
<223> Selenocysteine

<400> 2743
Met Lys Xaa Leu Ala Glu Arg Arg Arg Ser Ala Pro Ser Leu Ile Leu 
1               5                   10                  15      


Asp Lys Ala Leu Gln Lys Arg Pro Xaa Xaa Arg Asp Ser Pro Ser Ala 
            20                  25                  30          


Ser Val Asp Xaa Cys Xaa Phe Leu Ser Ser Leu Val Cys Ser Asn Arg 
        35                  40                  45              


Xaa Leu Leu Ile Asp Gly Arg Ala Glu Leu Lys Arg Gly Leu Gln Arg 
    50                  55                  60                  


Gln Glu Arg His Leu Phe Leu Phe Asn Asp Leu Phe Val Val Ala Lys 
65                  70                  75                  80  


Ile Lys Tyr Asn Asn Asn Phe Lys Ile Lys Asn Lys Ile Lys Leu Xaa 
                85                  90                  95      


Asp Met Trp Xaa Ala Ser Cys Val Asp Glu Val Gly Glu Gly Asn Xaa 
            100                 105                 110         


Asn Ala Met Lys Ser Phe Val Leu Gly Trp Pro Xaa Val Asn Phe Val 
        115                 120                 125             


Ala Xaa Phe Ser Ser Pro Glu Gln Lys Asp Lys Trp Leu Ser Leu Leu 
    130                 135                 140                 


Gln Arg Tyr Ile Asn Leu Glu Lys Glu Lys Asp Tyr Pro Lys Ser Ile 
145                 150                 155                 160 


Pro Leu Lys Ile Phe Ala Lys Asp Ile Gly Asn Cys Ala Tyr Ser Lys 
                165                 170                 175     


Xaa Ile Xaa Val Met Asn Ser Asp Xaa Ala Asn Glu Val Ile Asn Met 
            180                 185                 190         


Ser Leu Pro Met Leu Gly Ile Xaa Gly Ser Glu Arg Asp Tyr Gln Leu 
        195                 200                 205             


Trp Val Asn Ser Gly Lys Glu Glu Ala Pro Tyr Pro Leu Ile Gly His 
    210                 215                 220                 


Glu Tyr Pro Tyr Gly Ile Lys Met Ser His Leu Arg Asp Ser Ala Leu 
225                 230                 235                 240 


Leu Xaa Pro Gly Ser Lys Asp Ser Xaa Xaa Pro Phe Asn Leu Gln Glu 
                245                 250                 255     


Pro Phe Leu Met Glu Gln Leu Pro Arg Glu Met Gln Cys Gln Phe Ile 
            260                 265                 270         


Leu Lys Pro Ser Arg Leu Ala Ala Ala Gln Gln Leu Ser Asp Ser Gly 
        275                 280                 285             


His Lys Xaa Phe Lys Arg Arg Arg Ser Ile Ile Asn Trp Ala Phe Trp 
    290                 295                 300                 


Arg Gly Ser Ser Xaa His Leu Asp Asn Leu Pro Ser Ser Pro Xaa Ser 
305                 310                 315                 320 


Pro Met Pro Gly Gln Leu Phe Gly Ile Ser Leu Pro Asn Ile Cys Glu 
                325                 330                 335     


Asn Asp Asn Leu Pro Lys Pro Val Leu Asp Met Leu Phe Phe Leu Asn 
            340                 345                 350         


Gln Lys Gly Pro Leu Xaa Lys Gly Ile Phe Arg Gln Ser Ala Asn Val 
        355                 360                 365             


Lys Ser Cys Arg Glu Leu Lys Glu Lys Leu Asn Ser Gly Val Glu Val 
    370                 375                 380                 


His Leu Asp Cys Glu Ser Ile Phe Val Ile Ala Ser Val Leu Lys Asp 
385                 390                 395                 400 


Phe Leu Arg Asn Ile Pro Gly Ser Ile Phe Ser Ser Asp Leu Tyr Asp 
                405                 410                 415     


His Trp Val Ser Val Met Asp Gln Gly Asn Asp Glu Glu Lys Ile Asn 
            420                 425                 430         


Xaa Val Gln Arg Leu Leu Asp Gln Leu Pro Arg Ala Asn Val Val Leu 
        435                 440                 445             


Leu Arg Tyr Leu Phe Gly Val Leu His Asn Ile Glu Gln His Ser Ser 
    450                 455                 460                 


Ser Asn Gln Met Xaa Ala Phe Asn Leu Ala Val Cys Val Ala Pro Ser 
465                 470                 475                 480 


Ile Leu Trp Pro Pro Ala Ser Ser Ser Pro Glu Leu Glu Asn Glu Phe 
                485                 490                 495     


Xaa Lys Lys Val Ser Leu Leu Ile Gln Phe Leu Ile Glu Asn Cys Leu 
            500                 505                 510         


Arg Ile Phe Gly Glu Glu Ile Xaa Ser Leu Phe Arg Glu Val Ser Val 
        515                 520                 525             


Arg Cys Asp Xaa Arg Glu Asn Ala Ser Asp Ile Ser Cys Phe Gln Leu 
    530                 535                 540                 


Asn Asp Ser Ser Tyr Asp Ser Leu Glu Asn Glu Leu Asn Glu Asp Val 
545                 550                 555                 560 


Asp Ala Pro Cys Ser Asp Leu Val Lys Lys Leu Gly Gln Gly Ser Arg 
                565                 570                 575     


Ser Met Asp Ser Val Leu Xaa Leu Ser Asp Tyr Asp Leu Asp Gln Pro 
            580                 585                 590         


Glu Val Glu Gly Leu Leu Xaa Leu Ser Asp Phe Asp Leu Ala His Ser 
        595                 600                 605             


Lys Asp Glu Asp Val Gln Met Lys Arg Pro Leu Glu Ser Lys Pro Val 
    610                 615                 620                 


Asn Ile Leu Val Tyr Xaa Lys Ile Pro Leu Arg Asp His Ala Arg Ala 
625                 630                 635                 640 


Pro Ser Ala Met Cys Xaa Pro Ser Tyr Leu Ser Xaa Ala Ala Ala Asn 
                645                 650                 655     


Ala Ala Lys Ser Leu Arg Arg His Arg Arg Cys Ser Glu Pro Ser Ile 
            660                 665                 670         


Asp Tyr Leu Asp Ser Lys Leu Ser Tyr Leu Arg Glu Phe Tyr Gln Lys 
        675                 680                 685             


Lys Leu Arg Lys Ser Ser Cys Asp Ala Ile Leu Ser Gln Lys Asp Glu 
    690                 695                 700                 


Asp Tyr Leu Lys Gln Asn Gln Pro Leu Gln Glu Glu Gly Lys Xaa Cys 
705                 710                 715                 720 


Phe Lys Gln Ser Leu Val Xaa Gly Xaa Asp Val Ser Lys Lys Asn Ala 
                725                 730                 735     


Xaa Xaa Gln Asn Xaa Lys Lys Lys Ser Leu Ser Gly Ser Glu Gly Asn 
            740                 745                 750         


His Val Lys Leu Phe Pro Lys Ser Lys Pro Val Ala Ile Ser Val Ala 
        755                 760                 765             


Ser Tyr Ser Pro Met Ser Ser Gln Asp His Ser Lys Asn Gln Pro Phe 
    770                 775                 780                 


Asp Val Asn Xaa Ser Gly Tyr Ser Pro Pro His Xaa Ala Asp Ala Leu 
785                 790                 795                 800 


Lys Gly Pro Arg Xaa His Arg Arg Cys Ser Glu Pro Asn Ile Glu Asp 
                805                 810                 815     


Gln Asn Arg Lys Leu Xaa Tyr Leu Arg Gly Ile Tyr Ser Lys Lys Gln 
            820                 825                 830         


His Lys Xaa Ser Cys Glu Ala Gly Leu Leu His Gly Glu Glu Asp Tyr 
        835                 840                 845             


Leu Lys Arg His Lys Ser Leu Gln Met Glu Gly Gln Lys Leu Ile Asn 
    850                 855                 860                 


Gln Ser Leu Val Met Gly Ile Glu Val Gly Lys Ser Ser Ala Xaa Asn 
865                 870                 875                 880 


Gln Asn Xaa Glu Lys Val Leu Pro Pro Arg Leu Asn Leu Cys Pro Arg 
                885                 890                 895     


Xaa Ser Tyr Ser Ser Leu Ser Ser Pro Gly Xaa Ser Pro Ser Gly Ser 
            900                 905                 910         


Ser Val Ser Ser Gln Asp Ser Ala Phe Ser Gln Ile Ser Glu His Ser 
        915                 920                 925             


Val Phe Xaa Pro Xaa Glu Xaa Ser Ser Pro Ile Asp Cys Xaa Phe Gln 
    930                 935                 940                 


Ala Gln Arg Lys Arg Glu Asp Leu Ser Pro Asp Phe Ser Asn Ala Ser 
945                 950                 955                 960 


His Val Ser Gly Met Pro Gly Pro Ser Ser Gly Gln Ala Cys Ser Arg 
                965                 970                 975     


Pro Ala Tyr Xaa Lys Lys Asp Xaa Met Glu Trp His Ser Gln Met His 
            980                 985                 990         


Ser Val Xaa Leu His Pro Ser Xaa  Trp Leu Arg Asn Gly  Val Ala Ser 
        995                 1000                 1005             


Leu Lys  Asn Trp Ser Leu Lys  Lys Lys Ala Lys Ala  Ala Arg Pro 
    1010                 1015                 1020             


Glu Glu  Glu Lys Ile Ala Ser  Pro Lys Gly Pro Leu  Glu Pro Pro 
    1025                 1030                 1035             


Pro His  Ala Ser Gly Val Pro  Glu Ala Asn Ser Leu  Gln Glu Glu 
    1040                 1045                 1050             


Gln Lys  Asp Leu Pro Leu Arg  Ala Ala Glu Gly Leu  Ser Pro Val 
    1055                 1060                 1065             


Gln Ser  Ala Gln Arg Cys Ser  Ser Ser Pro Phe Gln  Asp Ser Glu 
    1070                 1075                 1080             


Arg His  Cys Ser Ser Pro Phe  Ser Leu Val Glu Ser  Arg Leu Lys 
    1085                 1090                 1095             


Leu Cys  Met Lys Ser His Glu  Glu Ile Glu Pro Gly  Ser Gln Ser 
    1100                 1105                 1110             


Ser Ser  Gly Ser Leu Pro Trp  Glu Arg Ala Ser Ala  Ser Ser Trp 
    1115                 1120                 1125             


Xaa Leu  Glu Asp Ala Xaa Ser  Pro Asp Ser Gly Pro  Xaa Val Val 
    1130                 1135                 1140             


Cys Asp  Ile Glu Asp Arg Tyr  Leu Xaa Lys Asp Ile  
    1145                 1150                 1155 


<210> 2744
<211> 1168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1165)
<223> Selenocysteine

<400> 2744
Met Ser Ala Arg Glu Arg Gln Pro Ala Leu Lys Lys Lys Met Lys Xaa 
1               5                   10                  15      


Leu Ala Glu Arg Arg Arg Ser Ala Pro Ser Leu Ile Leu Asp Lys Ala 
            20                  25                  30          


Leu Gln Lys Arg Pro Xaa Xaa Arg Asp Ser Pro Ser Ala Ser Val Asp 
        35                  40                  45              


Xaa Cys Xaa Phe Leu Ser Ser Leu Val Cys Ser Asn Arg Xaa Leu Leu 
    50                  55                  60                  


Ile Asp Gly Arg Ala Glu Leu Lys Arg Gly Leu Gln Arg Gln Glu Arg 
65                  70                  75                  80  


His Leu Phe Leu Phe Asn Asp Leu Phe Val Val Ala Lys Ile Lys Tyr 
                85                  90                  95      


Asn Asn Asn Phe Lys Ile Lys Asn Lys Ile Lys Leu Xaa Asp Met Trp 
            100                 105                 110         


Xaa Ala Ser Cys Val Asp Glu Val Gly Glu Gly Asn Xaa Asn Ala Met 
        115                 120                 125             


Lys Ser Phe Val Leu Gly Trp Pro Xaa Val Asn Phe Val Ala Xaa Phe 
    130                 135                 140                 


Ser Ser Pro Glu Gln Lys Asp Lys Trp Leu Ser Leu Leu Gln Arg Tyr 
145                 150                 155                 160 


Ile Asn Leu Glu Lys Glu Lys Asp Tyr Pro Lys Ser Ile Pro Leu Lys 
                165                 170                 175     


Ile Phe Ala Lys Asp Ile Gly Asn Cys Ala Tyr Ser Lys Xaa Ile Xaa 
            180                 185                 190         


Val Met Asn Ser Asp Xaa Ala Asn Glu Val Ile Asn Met Ser Leu Pro 
        195                 200                 205             


Met Leu Gly Ile Xaa Gly Ser Glu Arg Asp Tyr Gln Leu Trp Val Asn 
    210                 215                 220                 


Ser Gly Lys Glu Glu Ala Pro Tyr Pro Leu Ile Gly His Glu Tyr Pro 
225                 230                 235                 240 


Tyr Gly Ile Lys Met Ser His Leu Arg Asp Ser Ala Leu Leu Xaa Pro 
                245                 250                 255     


Gly Ser Lys Asp Ser Xaa Xaa Pro Phe Asn Leu Gln Glu Pro Phe Leu 
            260                 265                 270         


Met Glu Gln Leu Pro Arg Glu Met Gln Cys Gln Phe Ile Leu Lys Pro 
        275                 280                 285             


Ser Arg Leu Ala Ala Ala Gln Gln Leu Ser Asp Ser Gly His Lys Xaa 
    290                 295                 300                 


Phe Lys Arg Arg Arg Ser Ile Ile Asn Trp Ala Phe Trp Arg Gly Ser 
305                 310                 315                 320 


Ser Xaa His Leu Asp Asn Leu Pro Ser Ser Pro Xaa Ser Pro Met Pro 
                325                 330                 335     


Gly Gln Leu Phe Gly Ile Ser Leu Pro Asn Ile Cys Glu Asn Asp Asn 
            340                 345                 350         


Leu Pro Lys Pro Val Leu Asp Met Leu Phe Phe Leu Asn Gln Lys Gly 
        355                 360                 365             


Pro Leu Xaa Lys Gly Ile Phe Arg Gln Ser Ala Asn Val Lys Ser Cys 
    370                 375                 380                 


Arg Glu Leu Lys Glu Lys Leu Asn Ser Gly Val Glu Val His Leu Asp 
385                 390                 395                 400 


Cys Glu Ser Ile Phe Val Ile Ala Ser Val Leu Lys Asp Phe Leu Arg 
                405                 410                 415     


Asn Ile Pro Gly Ser Ile Phe Ser Ser Asp Leu Tyr Asp His Trp Val 
            420                 425                 430         


Ser Val Met Asp Gln Gly Asn Asp Glu Glu Lys Ile Asn Xaa Val Gln 
        435                 440                 445             


Arg Leu Leu Asp Gln Leu Pro Arg Ala Asn Val Val Leu Leu Arg Tyr 
    450                 455                 460                 


Leu Phe Gly Val Leu His Asn Ile Glu Gln His Ser Ser Ser Asn Gln 
465                 470                 475                 480 


Met Xaa Ala Phe Asn Leu Ala Val Cys Val Ala Pro Ser Ile Leu Trp 
                485                 490                 495     


Pro Pro Ala Ser Ser Ser Pro Glu Leu Glu Asn Glu Phe Xaa Lys Lys 
            500                 505                 510         


Val Ser Leu Leu Ile Gln Phe Leu Ile Glu Asn Cys Leu Arg Ile Phe 
        515                 520                 525             


Gly Glu Glu Ile Xaa Ser Leu Phe Arg Glu Val Ser Val Arg Cys Asp 
    530                 535                 540                 


Xaa Arg Glu Asn Ala Ser Asp Ile Ser Cys Phe Gln Leu Asn Asp Ser 
545                 550                 555                 560 


Ser Tyr Asp Ser Leu Glu Asn Glu Leu Asn Glu Asp Val Asp Ala Pro 
                565                 570                 575     


Cys Ser Asp Leu Val Lys Lys Leu Gly Gln Gly Ser Arg Ser Met Asp 
            580                 585                 590         


Ser Val Leu Xaa Leu Ser Asp Tyr Asp Leu Asp Gln Pro Glu Val Glu 
        595                 600                 605             


Gly Leu Leu Xaa Leu Ser Asp Phe Asp Leu Ala His Ser Lys Asp Glu 
    610                 615                 620                 


Asp Val Gln Met Lys Arg Pro Leu Glu Ser Lys Pro Val Asn Ile Leu 
625                 630                 635                 640 


Val Tyr Xaa Lys Ile Pro Leu Arg Asp His Ala Arg Ala Pro Ser Ala 
                645                 650                 655     


Met Cys Xaa Pro Ser Tyr Leu Ser Xaa Ala Ala Ala Asn Ala Ala Lys 
            660                 665                 670         


Ser Leu Arg Arg His Arg Arg Cys Ser Glu Pro Ser Ile Asp Tyr Leu 
        675                 680                 685             


Asp Ser Lys Leu Ser Tyr Leu Arg Glu Phe Tyr Gln Lys Lys Leu Arg 
    690                 695                 700                 


Lys Ser Ser Cys Asp Ala Ile Leu Ser Gln Lys Asp Glu Asp Tyr Leu 
705                 710                 715                 720 


Lys Gln Asn Gln Pro Leu Gln Glu Glu Gly Lys Xaa Cys Phe Lys Gln 
                725                 730                 735     


Ser Leu Val Xaa Gly Xaa Asp Val Ser Lys Lys Asn Ala Xaa Xaa Gln 
            740                 745                 750         


Asn Xaa Lys Lys Lys Ser Leu Ser Gly Ser Glu Gly Asn His Val Lys 
        755                 760                 765             


Leu Phe Pro Lys Ser Lys Pro Val Ala Ile Ser Val Ala Ser Tyr Ser 
    770                 775                 780                 


Pro Met Ser Ser Gln Asp His Ser Lys Asn Gln Pro Phe Asp Val Asn 
785                 790                 795                 800 


Xaa Ser Gly Tyr Ser Pro Pro His Xaa Ala Asp Ala Leu Lys Gly Pro 
                805                 810                 815     


Arg Xaa His Arg Arg Cys Ser Glu Pro Asn Ile Glu Asp Gln Asn Arg 
            820                 825                 830         


Lys Leu Xaa Tyr Leu Arg Gly Ile Tyr Ser Lys Lys Gln His Lys Xaa 
        835                 840                 845             


Ser Cys Glu Ala Gly Leu Leu His Gly Glu Glu Asp Tyr Leu Lys Arg 
    850                 855                 860                 


His Lys Ser Leu Gln Met Glu Gly Gln Lys Leu Ile Asn Gln Ser Leu 
865                 870                 875                 880 


Val Met Gly Ile Glu Val Gly Lys Ser Ser Ala Xaa Asn Gln Asn Xaa 
                885                 890                 895     


Glu Lys Val Leu Pro Pro Arg Leu Asn Leu Cys Pro Arg Xaa Ser Tyr 
            900                 905                 910         


Ser Ser Leu Ser Ser Pro Gly Xaa Ser Pro Ser Gly Ser Ser Val Ser 
        915                 920                 925             


Ser Gln Asp Ser Ala Phe Ser Gln Ile Ser Glu His Ser Val Phe Xaa 
    930                 935                 940                 


Pro Xaa Glu Xaa Ser Ser Pro Ile Asp Cys Xaa Phe Gln Ala Gln Arg 
945                 950                 955                 960 


Lys Arg Glu Asp Leu Ser Pro Asp Phe Ser Asn Ala Ser His Val Ser 
                965                 970                 975     


Gly Met Pro Gly Pro Ser Ser Gly Gln Ala Cys Ser Arg Pro Ala Tyr 
            980                 985                 990         


Xaa Lys Lys Asp Xaa Met Glu Trp  His Ser Gln Met His  Ser Val Xaa 
        995                 1000                 1005             


Leu His  Pro Ser Xaa Trp Leu  Arg Asn Gly Val Ala  Ser Leu Lys 
    1010                 1015                 1020             


Asn Trp  Ser Leu Lys Lys Lys  Ala Lys Ala Ala Arg  Pro Glu Glu 
    1025                 1030                 1035             


Glu Lys  Ile Ala Ser Pro Lys  Gly Pro Leu Glu Pro  Pro Pro His 
    1040                 1045                 1050             


Ala Ser  Gly Val Pro Glu Ala  Asn Ser Leu Gln Glu  Glu Gln Lys 
    1055                 1060                 1065             


Asp Leu  Pro Leu Arg Ala Ala  Glu Gly Leu Ser Pro  Val Gln Ser 
    1070                 1075                 1080             


Ala Gln  Arg Cys Ser Ser Ser  Pro Phe Gln Asp Ser  Glu Arg His 
    1085                 1090                 1095             


Cys Ser  Ser Pro Phe Ser Leu  Val Glu Ser Arg Leu  Lys Leu Cys 
    1100                 1105                 1110             


Met Lys  Ser His Glu Glu Ile  Glu Pro Gly Ser Gln  Ser Ser Ser 
    1115                 1120                 1125             


Gly Ser  Leu Pro Trp Glu Arg  Ala Ser Ala Ser Ser  Trp Xaa Leu 
    1130                 1135                 1140             


Glu Asp  Ala Xaa Ser Pro Asp  Ser Gly Pro Xaa Val  Val Cys Asp 
    1145                 1150                 1155             


Ile Glu  Asp Arg Tyr Leu Xaa  Lys Asp Ile 
    1160                 1165             


<210> 2745
<211> 1165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<400> 2745
Met Xaa Phe Trp Ile Ile Ile Asn Lys Lys Met Lys Xaa Leu Ala Glu 
1               5                   10                  15      


Arg Arg Arg Ser Ala Pro Ser Leu Ile Leu Asp Lys Ala Leu Gln Lys 
            20                  25                  30          


Arg Pro Xaa Xaa Arg Asp Ser Pro Ser Ala Ser Val Asp Xaa Cys Xaa 
        35                  40                  45              


Phe Leu Ser Ser Leu Val Cys Ser Asn Arg Xaa Leu Leu Ile Asp Gly 
    50                  55                  60                  


Arg Ala Glu Leu Lys Arg Gly Leu Gln Arg Gln Glu Arg His Leu Phe 
65                  70                  75                  80  


Leu Phe Asn Asp Leu Phe Val Val Ala Lys Ile Lys Tyr Asn Asn Asn 
                85                  90                  95      


Phe Lys Ile Lys Asn Lys Ile Lys Leu Xaa Asp Met Trp Xaa Ala Ser 
            100                 105                 110         


Cys Val Asp Glu Val Gly Glu Gly Asn Xaa Asn Ala Met Lys Ser Phe 
        115                 120                 125             


Val Leu Gly Trp Pro Xaa Val Asn Phe Val Ala Xaa Phe Ser Ser Pro 
    130                 135                 140                 


Glu Gln Lys Asp Lys Trp Leu Ser Leu Leu Gln Arg Tyr Ile Asn Leu 
145                 150                 155                 160 


Glu Lys Glu Lys Asp Tyr Pro Lys Ser Ile Pro Leu Lys Ile Phe Ala 
                165                 170                 175     


Lys Asp Ile Gly Asn Cys Ala Tyr Ser Lys Xaa Ile Xaa Val Met Asn 
            180                 185                 190         


Ser Asp Xaa Ala Asn Glu Val Ile Asn Met Ser Leu Pro Met Leu Gly 
        195                 200                 205             


Ile Xaa Gly Ser Glu Arg Asp Tyr Gln Leu Trp Val Asn Ser Gly Lys 
    210                 215                 220                 


Glu Glu Ala Pro Tyr Pro Leu Ile Gly His Glu Tyr Pro Tyr Gly Ile 
225                 230                 235                 240 


Lys Met Ser His Leu Arg Asp Ser Ala Leu Leu Xaa Pro Gly Ser Lys 
                245                 250                 255     


Asp Ser Xaa Xaa Pro Phe Asn Leu Gln Glu Pro Phe Leu Met Glu Gln 
            260                 265                 270         


Leu Pro Arg Glu Met Gln Cys Gln Phe Ile Leu Lys Pro Ser Arg Leu 
        275                 280                 285             


Ala Ala Ala Gln Gln Leu Ser Asp Ser Gly His Lys Xaa Phe Lys Arg 
    290                 295                 300                 


Arg Arg Ser Ile Ile Asn Trp Ala Phe Trp Arg Gly Ser Ser Xaa His 
305                 310                 315                 320 


Leu Asp Asn Leu Pro Ser Ser Pro Xaa Ser Pro Met Pro Gly Gln Leu 
                325                 330                 335     


Phe Gly Ile Ser Leu Pro Asn Ile Cys Glu Asn Asp Asn Leu Pro Lys 
            340                 345                 350         


Pro Val Leu Asp Met Leu Phe Phe Leu Asn Gln Lys Gly Pro Leu Xaa 
        355                 360                 365             


Lys Gly Ile Phe Arg Gln Ser Ala Asn Val Lys Ser Cys Arg Glu Leu 
    370                 375                 380                 


Lys Glu Lys Leu Asn Ser Gly Val Glu Val His Leu Asp Cys Glu Ser 
385                 390                 395                 400 


Ile Phe Val Ile Ala Ser Val Leu Lys Asp Phe Leu Arg Asn Ile Pro 
                405                 410                 415     


Gly Ser Ile Phe Ser Ser Asp Leu Tyr Asp His Trp Val Ser Val Met 
            420                 425                 430         


Asp Gln Gly Asn Asp Glu Glu Lys Ile Asn Xaa Val Gln Arg Leu Leu 
        435                 440                 445             


Asp Gln Leu Pro Arg Ala Asn Val Val Leu Leu Arg Tyr Leu Phe Gly 
    450                 455                 460                 


Val Leu His Asn Ile Glu Gln His Ser Ser Ser Asn Gln Met Xaa Ala 
465                 470                 475                 480 


Phe Asn Leu Ala Val Cys Val Ala Pro Ser Ile Leu Trp Pro Pro Ala 
                485                 490                 495     


Ser Ser Ser Pro Glu Leu Glu Asn Glu Phe Xaa Lys Lys Val Ser Leu 
            500                 505                 510         


Leu Ile Gln Phe Leu Ile Glu Asn Cys Leu Arg Ile Phe Gly Glu Glu 
        515                 520                 525             


Ile Xaa Ser Leu Phe Arg Glu Val Ser Val Arg Cys Asp Xaa Arg Glu 
    530                 535                 540                 


Asn Ala Ser Asp Ile Ser Cys Phe Gln Leu Asn Asp Ser Ser Tyr Asp 
545                 550                 555                 560 


Ser Leu Glu Asn Glu Leu Asn Glu Asp Val Asp Ala Pro Cys Ser Asp 
                565                 570                 575     


Leu Val Lys Lys Leu Gly Gln Gly Ser Arg Ser Met Asp Ser Val Leu 
            580                 585                 590         


Xaa Leu Ser Asp Tyr Asp Leu Asp Gln Pro Glu Val Glu Gly Leu Leu 
        595                 600                 605             


Xaa Leu Ser Asp Phe Asp Leu Ala His Ser Lys Asp Glu Asp Val Gln 
    610                 615                 620                 


Met Lys Arg Pro Leu Glu Ser Lys Pro Val Asn Ile Leu Val Tyr Xaa 
625                 630                 635                 640 


Lys Ile Pro Leu Arg Asp His Ala Arg Ala Pro Ser Ala Met Cys Xaa 
                645                 650                 655     


Pro Ser Tyr Leu Ser Xaa Ala Ala Ala Asn Ala Ala Lys Ser Leu Arg 
            660                 665                 670         


Arg His Arg Arg Cys Ser Glu Pro Ser Ile Asp Tyr Leu Asp Ser Lys 
        675                 680                 685             


Leu Ser Tyr Leu Arg Glu Phe Tyr Gln Lys Lys Leu Arg Lys Ser Ser 
    690                 695                 700                 


Cys Asp Ala Ile Leu Ser Gln Lys Asp Glu Asp Tyr Leu Lys Gln Asn 
705                 710                 715                 720 


Gln Pro Leu Gln Glu Glu Gly Lys Xaa Cys Phe Lys Gln Ser Leu Val 
                725                 730                 735     


Xaa Gly Xaa Asp Val Ser Lys Lys Asn Ala Xaa Xaa Gln Asn Xaa Lys 
            740                 745                 750         


Lys Lys Ser Leu Ser Gly Ser Glu Gly Asn His Val Lys Leu Phe Pro 
        755                 760                 765             


Lys Ser Lys Pro Val Ala Ile Ser Val Ala Ser Tyr Ser Pro Met Ser 
    770                 775                 780                 


Ser Gln Asp His Ser Lys Asn Gln Pro Phe Asp Val Asn Xaa Ser Gly 
785                 790                 795                 800 


Tyr Ser Pro Pro His Xaa Ala Asp Ala Leu Lys Gly Pro Arg Xaa His 
                805                 810                 815     


Arg Arg Cys Ser Glu Pro Asn Ile Glu Asp Gln Asn Arg Lys Leu Xaa 
            820                 825                 830         


Tyr Leu Arg Gly Ile Tyr Ser Lys Lys Gln His Lys Xaa Ser Cys Glu 
        835                 840                 845             


Ala Gly Leu Leu His Gly Glu Glu Asp Tyr Leu Lys Arg His Lys Ser 
    850                 855                 860                 


Leu Gln Met Glu Gly Gln Lys Leu Ile Asn Gln Ser Leu Val Met Gly 
865                 870                 875                 880 


Ile Glu Val Gly Lys Ser Ser Ala Xaa Asn Gln Asn Xaa Glu Lys Val 
                885                 890                 895     


Leu Pro Pro Arg Leu Asn Leu Cys Pro Arg Xaa Ser Tyr Ser Ser Leu 
            900                 905                 910         


Ser Ser Pro Gly Xaa Ser Pro Ser Gly Ser Ser Val Ser Ser Gln Asp 
        915                 920                 925             


Ser Ala Phe Ser Gln Ile Ser Glu His Ser Val Phe Xaa Pro Xaa Glu 
    930                 935                 940                 


Xaa Ser Ser Pro Ile Asp Cys Xaa Phe Gln Ala Gln Arg Lys Arg Glu 
945                 950                 955                 960 


Asp Leu Ser Pro Asp Phe Ser Asn Ala Ser His Val Ser Gly Met Pro 
                965                 970                 975     


Gly Pro Ser Ser Gly Gln Ala Cys Ser Arg Pro Ala Tyr Xaa Lys Lys 
            980                 985                 990         


Asp Xaa Met Glu Trp His Ser Gln  Met His Ser Val Xaa  Leu His Pro 
        995                 1000                 1005             


Ser Xaa  Trp Leu Arg Asn Gly  Val Ala Ser Leu Lys  Asn Trp Ser 
    1010                 1015                 1020             


Leu Lys  Lys Lys Ala Lys Ala  Ala Arg Pro Glu Glu  Glu Lys Ile 
    1025                 1030                 1035             


Ala Ser  Pro Lys Gly Pro Leu  Glu Pro Pro Pro His  Ala Ser Gly 
    1040                 1045                 1050             


Val Pro  Glu Ala Asn Ser Leu  Gln Glu Glu Gln Lys  Asp Leu Pro 
    1055                 1060                 1065             


Leu Arg  Ala Ala Glu Gly Leu  Ser Pro Val Gln Ser  Ala Gln Arg 
    1070                 1075                 1080             


Cys Ser  Ser Ser Pro Phe Gln  Asp Ser Glu Arg His  Cys Ser Ser 
    1085                 1090                 1095             


Pro Phe  Ser Leu Val Glu Ser  Arg Leu Lys Leu Cys  Met Lys Ser 
    1100                 1105                 1110             


His Glu  Glu Ile Glu Pro Gly  Ser Gln Ser Ser Ser  Gly Ser Leu 
    1115                 1120                 1125             


Pro Trp  Glu Arg Ala Ser Ala  Ser Ser Trp Xaa Leu  Glu Asp Ala 
    1130                 1135                 1140             


Xaa Ser  Pro Asp Ser Gly Pro  Xaa Val Val Cys Asp  Ile Glu Asp 
    1145                 1150                 1155             


Arg Tyr  Leu Xaa Lys Asp Ile  
    1160                 1165 


<210> 2746
<211> 179
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 2746
Gly Asp Gly Asp Lys Leu Lys Ala Cys Glu Val Ser Lys Asn Lys Asp 
1               5                   10                  15      


Gly Lys Glu Gln Ser Glu Xaa Val Ser Leu Ser Glu Asp Glu Xaa Phe 
            20                  25                  30          


Ser Trp Pro Gly Pro Lys Xaa Val Xaa Leu Lys Arg Xaa Ser Gln Gly 
        35                  40                  45              


Phe Gly Phe Xaa Leu Arg His Phe Ile Val Tyr Pro Pro Glu Ser Ala 
    50                  55                  60                  


Ile Gln Phe Ser Tyr Lys Asp Glu Glu Asn Gly Asn Arg Gly Gly Lys 
65                  70                  75                  80  


Gln Arg Asn Arg Leu Glu Pro Met Asp Xaa Ile Phe Val Lys Gln Val 
                85                  90                  95      


Lys Glu Gly Gly Pro Ala Phe Glu Ala Gly Leu Cys Xaa Gly Asp Arg 
            100                 105                 110         


Ile Ile Lys Val Asn Gly Glu Ser Val Ile Gly Lys Xaa Tyr Ser Gln 
        115                 120                 125             


Val Ile Ala Leu Ile Gln Asn Ser Asp Xaa Xaa Leu Glu Leu Ser Val 
    130                 135                 140                 


Met Pro Lys Asp Glu Asp Ile Leu Gln Val Asn Leu Glu Phe Ser Xaa 
145                 150                 155                 160 


Phe Tyr Lys Asn Xaa Ile Ala Lys Phe Leu Gln Leu Ser Asp Met Glu 
                165                 170                 175     


Met Leu Cys 
            


<210> 2747
<211> 489
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<400> 2747
Ile Ala Asp Ser Gln Lys Ser Ser Glu Asp Ser Gly Ser Arg Lys Asp 
1               5                   10                  15      


Ser Ser Ser Glu Val Phe Ser Asp Ala Ala Lys Glu Gly Trp Leu His 
            20                  25                  30          


Phe Arg Pro Leu Val Xaa Asp Lys Gly Lys Arg Val Gly Gly Ser Ile 
        35                  40                  45              


Arg Pro Trp Lys Gln Met Tyr Val Val Leu Arg Gly His Ser Leu Tyr 
    50                  55                  60                  


Leu Tyr Lys Asp Lys Arg Glu Gln Xaa Xaa Pro Ser Glu Glu Glu Gln 
65                  70                  75                  80  


Pro Ile Ser Val Asn Ala Cys Leu Ile Asp Ile Ser Tyr Ser Glu Xaa 
                85                  90                  95      


Lys Arg Lys Asn Val Phe Arg Leu Xaa Xaa Ser Asp Cys Glu Cys Leu 
            100                 105                 110         


Phe Gln Ala Glu Asp Arg Asp Asp Met Leu Ala Trp Ile Lys Xaa Ile 
        115                 120                 125             


Gln Glu Ser Ser Asn Leu Asn Glu Glu Asp Xaa Gly Val Xaa Asn Arg 
    130                 135                 140                 


Asp Leu Ile Ser Arg Arg Ile Lys Glu Tyr Asn Asn Leu Met Ser Lys 
145                 150                 155                 160 


Ala Glu Gln Leu Pro Lys Xaa Pro Arg Gln Ser Leu Ser Ile Arg Gln 
                165                 170                 175     


Xaa Leu Leu Gly Ala Lys Ser Glu Pro Lys Xaa Gln Ser Pro His Ser 
            180                 185                 190         


Pro Lys Glu Glu Ser Glu Arg Lys Leu Leu Ser Lys Asp Asp Xaa Ser 
        195                 200                 205             


Pro Pro Lys Asp Lys Gly Xaa Trp Arg Lys Gly Ile Pro Ser Ile Met 
    210                 215                 220                 


Arg Lys Xaa Phe Glu Lys Lys Pro Xaa Ala Xaa Gly Xaa Phe Gly Val 
225                 230                 235                 240 


Arg Leu Asp Asp Cys Pro Pro Ala His Xaa Asn Arg Tyr Ile Pro Leu 
                245                 250                 255     


Ile Val Asp Ile Cys Cys Lys Leu Val Glu Glu Arg Gly Leu Glu Tyr 
            260                 265                 270         


Xaa Gly Ile Tyr Arg Val Pro Gly Asn Asn Ala Ala Ile Ser Ser Met 
        275                 280                 285             


Gln Glu Glu Leu Asn Lys Gly Met Ala Asp Ile Asp Ile Gln Asp Asp 
    290                 295                 300                 


Lys Trp Arg Asp Leu Asn Val Ile Ser Ser Leu Leu Lys Ser Phe Phe 
305                 310                 315                 320 


Arg Lys Leu Pro Glu Pro Leu Phe Xaa Asn Asp Lys Tyr Ala Asp Phe 
                325                 330                 335     


Ile Glu Ala Asn Arg Lys Glu Asp Pro Leu Asp Arg Leu Lys Xaa Leu 
            340                 345                 350         


Lys Arg Leu Ile His Asp Leu Pro Glu His His Tyr Glu Xaa Leu Lys 
        355                 360                 365             


Phe Leu Ser Ala His Leu Lys Xaa Val Ala Glu Asn Ser Glu Lys Asn 
    370                 375                 380                 


Lys Met Glu Pro Arg Asn Leu Ala Ile Val Phe Gly Pro Xaa Leu Val 
385                 390                 395                 400 


Arg Xaa Ser Glu Asp Asn Met Xaa His Met Val Xaa His Met Pro Asp 
                405                 410                 415     


Gln Tyr Lys Ile Val Glu Xaa Leu Ile Gln His His Asp Trp Phe Phe 
            420                 425                 430         


Xaa Glu Glu Gly Ala Glu Glu Pro Leu Xaa Xaa Val Gln Glu Glu Ser 
        435                 440                 445             


Xaa Val Asp Ser Gln Pro Val Pro Asn Ile Asp His Leu Leu Xaa Asn 
    450                 455                 460                 


Ile Gly Arg Xaa Gly Val Ser Pro Gly Asp Val Ser Val Leu Val Leu 
465                 470                 475                 480 


Val Leu Lys Gly Phe Phe Ser Ser Tyr 
                485                 


<210> 2748
<211> 172
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(157)
<223> Selenocysteine

<400> 2748
Met Ala Gln Phe Arg Ile Leu Asp Cys Met Ile Asn His Asn Trp Ser 
1               5                   10                  15      


Leu Leu Cys Asn Leu Tyr Cys Ala Trp Ser Gly Gln Val Ser Lys Asn 
            20                  25                  30          


Lys Asp Gly Lys Glu Gln Ser Glu Xaa Val Ser Leu Ser Glu Asp Glu 
        35                  40                  45              


Xaa Phe Ser Trp Pro Gly Pro Lys Xaa Val Xaa Leu Lys Arg Xaa Ser 
    50                  55                  60                  


Gln Gly Phe Gly Phe Xaa Leu Arg His Phe Ile Val Tyr Pro Pro Glu 
65                  70                  75                  80  


Ser Ala Ile Gln Phe Ser Tyr Lys Asp Glu Glu Asn Gly Asn Arg Gly 
                85                  90                  95      


Gly Lys Gln Arg Asn Arg Leu Glu Pro Met Asp Xaa Ile Phe Val Lys 
            100                 105                 110         


Gln Val Lys Glu Gly Gly Pro Ala Phe Glu Ala Gly Leu Cys Xaa Gly 
        115                 120                 125             


Asp Arg Ile Ile Lys Val Asn Gly Glu Ser Val Ile Gly Lys Xaa Tyr 
    130                 135                 140                 


Ser Gln Val Ile Ala Leu Ile Gln Asn Ser Asp Xaa Xaa Leu Glu Leu 
145                 150                 155                 160 


Ser Val Met Pro Lys Asp Glu Asp Ile Leu Gln Val 
                165                 170         


<210> 2749
<211> 1217
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1106)..(1106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1117)..(1117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1179)..(1179)
<223> Selenocysteine

<400> 2749
Met Ala Gln Pro Val Glu Ile Ser Pro Pro Asp Ser Ser Leu Ser Lys 
1               5                   10                  15      


Gln Gln Xaa Ser Xaa Pro Val Leu Xaa Gln Pro Gly Arg Ala Tyr Arg 
            20                  25                  30          


Met Glu Ile Gln Val Pro Pro Ser Pro Xaa Asp Val Ala Lys Ser Asn 
        35                  40                  45              


Xaa Ala Val Cys Val Cys Asn Glu Ser Val Arg Xaa Val Ile Val Pro 
    50                  55                  60                  


Ser Glu Lys Val Val Asp Leu Leu Ser Asn Arg Asn Asn His Xaa Gly 
65                  70                  75                  80  


Pro Ser His Arg Xaa Glu Glu Val Arg Tyr Gly Val Ser Glu Gln Xaa 
                85                  90                  95      


Ser Leu Lys Xaa Val Ser Arg Xaa Xaa Ser Pro Pro Leu Ser Ile Pro 
            100                 105                 110         


Xaa Xaa His Leu Ile His Gln Pro Ala Gly Ser Arg Ser Leu Glu Pro 
        115                 120                 125             


Ser Gly Ile Leu Leu Lys Ser Gly Asn Tyr Ser Gly His Ser Asp Gly 
    130                 135                 140                 


Ile Ser Ser Ser Arg Ser Gln Ala Val Glu Ala Pro Ser Val Ser Val 
145                 150                 155                 160 


Asn His Tyr Ser Pro Asn Ser His Gln His Ile Asp Trp Lys Asn Tyr 
                165                 170                 175     


Lys Xaa Tyr Lys Glu Tyr Ile Asp Asn Arg Arg Leu His Ile Gly Cys 
            180                 185                 190         


Arg Xaa Ile Gln Glu Arg Leu Asp Ser Leu Arg Ala Ala Ser Gln Ser 
        195                 200                 205             


Xaa Xaa Asp Tyr Asn Gln Val Val Pro Asn Arg Xaa Xaa Leu Gln Gly 
    210                 215                 220                 


Arg Arg Arg Ser Xaa Ser His Asp Arg Val Pro Gln Ser Val Gln Ile 
225                 230                 235                 240 


Arg Gln Arg Ser Val Ser Gln Glu Arg Leu Glu Asp Ser Val Leu Met 
                245                 250                 255     


Lys Tyr Cys Pro Arg Ser Ala Ser Gln Gly Ala Leu Xaa Ser Pro Ser 
            260                 265                 270         


Val Ser Phe Ser Asn His Arg Xaa Arg Ser Trp Asp Tyr Ile Glu Gly 
        275                 280                 285             


Gln Asp Glu Xaa Leu Glu Asn Val Asn Ser Gly Xaa Pro Ile Pro Asp 
    290                 295                 300                 


Ser Asn Gly Glu Lys Lys Gln Xaa Tyr Lys Trp Ser Gly Phe Xaa Glu 
305                 310                 315                 320 


Gln Asp Asp Arg Arg Gly Ile Cys Glu Arg Pro Arg Gln Gln Glu Ile 
                325                 330                 335     


His Lys Ser Phe Arg Gly Ser Asn Phe Xaa Val Ala Pro Ser Val Val 
            340                 345                 350         


Asn Ser Asp Asn Arg Arg Met Ser Gly Arg Gly Val Gly Ser Val Ser 
        355                 360                 365             


Gln Phe Lys Lys Ile Pro Pro Asp Leu Lys Xaa Leu Gln Ser Asn Arg 
    370                 375                 380                 


Asn Phe Gln Xaa Xaa Cys Gly Met Ser Leu Pro Arg Gly Ile Ser Gln 
385                 390                 395                 400 


Asp Arg Ser Pro Leu Val Lys Val Arg Ser Asn Ser Leu Lys Ala Pro 
                405                 410                 415     


Ser Xaa His Val Xaa Lys Pro Ser Phe Ser Gln Lys Ser Phe Val Ser 
            420                 425                 430         


Ile Lys Asp Gln Arg Pro Val Asn His Leu His Gln Asn Ser Leu Leu 
        435                 440                 445             


Asn Gln Gln Xaa Trp Val Arg Xaa Asp Ser Ala Pro Asp Gln Gln Val 
    450                 455                 460                 


Glu Xaa Gly Lys Ser Pro Ser Leu Ser Gly Ala Ser Ala Lys Pro Ala 
465                 470                 475                 480 


Pro Gln Ser Ser Glu Asn Ala Gly Xaa Ser Asp Leu Glu Leu Pro Val 
                485                 490                 495     


Ser Gln Arg Asn Gln Asp Leu Ser Leu Gln Glu Ala Glu Xaa Glu Gln 
            500                 505                 510         


Ser Asp Xaa Leu Asp Asn Lys Glu Ala Val Ile Leu Arg Glu Lys Pro 
        515                 520                 525             


Pro Ser Gly Arg Gln Xaa Pro Gln Pro Leu Arg His Gln Ser Tyr Ile 
    530                 535                 540                 


Leu Ala Val Asn Asp Gln Glu Xaa Gly Ser Asp Xaa Xaa Cys Trp Leu 
545                 550                 555                 560 


Pro Asn Asp Ala Arg Arg Glu Val His Ile Lys Arg Met Glu Glu Arg 
                565                 570                 575     


Lys Ala Ser Ser Xaa Ser Pro Pro Gly Asp Ser Leu Ala Ser Ile Pro 
            580                 585                 590         


Phe Ile Asp Glu Pro Xaa Ser Pro Ser Ile Asp His Asp Ile Ala His 
        595                 600                 605             


Ile Pro Ala Ser Ala Val Ile Ser Ala Ser Xaa Ser Gln Val Pro Ser 
    610                 615                 620                 


Ile Ala Xaa Val Pro Pro Cys Leu Xaa Xaa Ser Ala Pro Leu Ile Arg 
625                 630                 635                 640 


Arg Gln Leu Ser His Asp His Glu Ser Val Gly Pro Pro Ser Leu Asp 
                645                 650                 655     


Ala Gln Pro Asn Ser Lys Xaa Glu Arg Ser Lys Ser Tyr Asp Glu Gly 
            660                 665                 670         


Leu Asp Asp Tyr Arg Glu Asp Ala Lys Leu Ser Phe Lys His Val Ser 
        675                 680                 685             


Ser Leu Lys Gly Ile Lys Ile Ala Asp Ser Gln Lys Ser Ser Glu Asp 
    690                 695                 700                 


Ser Gly Ser Arg Lys Asp Ser Ser Ser Glu Val Phe Ser Asp Ala Ala 
705                 710                 715                 720 


Lys Glu Gly Trp Leu His Phe Arg Pro Leu Val Xaa Asp Lys Gly Lys 
                725                 730                 735     


Arg Val Gly Gly Ser Ile Arg Pro Trp Lys Gln Met Tyr Val Val Leu 
            740                 745                 750         


Arg Gly His Ser Leu Tyr Leu Tyr Lys Asp Lys Arg Glu Gln Xaa Xaa 
        755                 760                 765             


Pro Ser Glu Glu Glu Gln Pro Ile Ser Val Asn Ala Cys Leu Ile Asp 
    770                 775                 780                 


Ile Ser Tyr Ser Glu Xaa Lys Arg Lys Asn Val Phe Arg Leu Xaa Xaa 
785                 790                 795                 800 


Ser Asp Cys Glu Cys Leu Phe Gln Ala Glu Asp Arg Asp Asp Met Leu 
                805                 810                 815     


Ala Trp Ile Lys Xaa Ile Gln Glu Ser Ser Asn Leu Asn Glu Glu Asp 
            820                 825                 830         


Xaa Gly Val Xaa Asn Arg Asp Leu Ile Ser Arg Arg Ile Lys Glu Tyr 
        835                 840                 845             


Asn Asn Leu Met Ser Lys Ala Glu Gln Leu Pro Lys Xaa Pro Arg Gln 
    850                 855                 860                 


Ser Leu Ser Ile Arg Gln Xaa Leu Leu Gly Ala Lys Ser Glu Pro Lys 
865                 870                 875                 880 


Xaa Gln Ser Pro His Ser Pro Lys Glu Glu Ser Glu Arg Lys Leu Leu 
                885                 890                 895     


Ser Lys Asp Asp Xaa Ser Pro Pro Lys Asp Lys Gly Xaa Trp Arg Lys 
            900                 905                 910         


Gly Ile Pro Ser Ile Met Arg Lys Xaa Phe Glu Lys Lys Pro Xaa Ala 
        915                 920                 925             


Xaa Gly Xaa Phe Gly Val Arg Leu Asp Asp Cys Pro Pro Ala His Xaa 
    930                 935                 940                 


Asn Arg Tyr Ile Pro Leu Ile Val Asp Ile Cys Cys Lys Leu Val Glu 
945                 950                 955                 960 


Glu Arg Gly Leu Glu Tyr Xaa Gly Ile Tyr Arg Val Pro Gly Asn Asn 
                965                 970                 975     


Ala Ala Ile Ser Ser Met Gln Glu Glu Leu Asn Lys Gly Met Ala Asp 
            980                 985                 990         


Ile Asp Ile Gln Asp Asp Lys Trp  Arg Asp Leu Asn Val  Ile Ser Ser 
        995                 1000                 1005             


Leu Leu  Lys Ser Phe Phe Arg  Lys Leu Pro Glu Pro  Leu Phe Xaa 
    1010                 1015                 1020             


Asn Asp  Lys Tyr Ala Asp Phe  Ile Glu Ala Asn Arg  Lys Glu Asp 
    1025                 1030                 1035             


Pro Leu  Asp Arg Leu Lys Xaa  Leu Lys Arg Leu Ile  His Asp Leu 
    1040                 1045                 1050             


Pro Glu  His His Tyr Glu Xaa  Leu Lys Phe Leu Ser  Ala His Leu 
    1055                 1060                 1065             


Lys Xaa  Val Ala Glu Asn Ser  Glu Lys Asn Lys Met  Glu Pro Arg 
    1070                 1075                 1080             


Asn Leu  Ala Ile Val Phe Gly  Pro Xaa Leu Val Arg  Xaa Ser Glu 
    1085                 1090                 1095             


Asp Asn  Met Xaa His Met Val  Xaa His Met Pro Asp  Gln Tyr Lys 
    1100                 1105                 1110             


Ile Val  Glu Xaa Leu Ile Gln  His His Asp Trp Phe  Phe Xaa Glu 
    1115                 1120                 1125             


Glu Gly  Ala Glu Glu Pro Leu  Xaa Xaa Val Gln Glu  Glu Ser Xaa 
    1130                 1135                 1140             


Val Asp  Ser Gln Pro Val Pro  Asn Ile Asp His Leu  Leu Xaa Asn 
    1145                 1150                 1155             


Ile Gly  Arg Xaa Gly Val Ser  Pro Gly Asp Val Ser  Gly Glu Val 
    1160                 1165                 1170             


Gly Gly  Val Tyr His Xaa Val  Met Ser Leu Val Asp  Ser Val Met 
    1175                 1180                 1185             


Ser Leu  Met Asp Ser Trp Asn  Cys Arg Lys Lys Glu  Asp Cys Cys 
    1190                 1195                 1200             


Pro His  Cys Ser Cys Leu Val  Cys Arg Asn Pro Arg  Phe Leu 
    1205                 1210                 1215         


<210> 2750
<211> 1406
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (996)..(996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1083)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1179)..(1179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1191)..(1191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1208)..(1208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1211)..(1211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1240)..(1240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1308)..(1308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1323)..(1323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1328)..(1328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1344)..(1344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1354)..(1354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1395)..(1395)
<223> Selenocysteine

<400> 2750
Met Ala Xaa Arg Arg Xaa Gly Leu Ser Glu Gly Asp Gly Asp Lys Leu 
1               5                   10                  15      


Lys Ala Cys Glu Val Ser Lys Asn Lys Asp Gly Lys Glu Gln Ser Glu 
            20                  25                  30          


Xaa Val Ser Leu Ser Glu Asp Glu Xaa Phe Ser Trp Pro Gly Pro Lys 
        35                  40                  45              


Xaa Val Xaa Leu Lys Arg Xaa Ser Gln Gly Phe Gly Phe Xaa Leu Arg 
    50                  55                  60                  


His Phe Ile Val Tyr Pro Pro Glu Ser Ala Ile Gln Phe Ser Tyr Lys 
65                  70                  75                  80  


Asp Glu Glu Asn Gly Asn Arg Gly Gly Lys Gln Arg Asn Arg Leu Glu 
                85                  90                  95      


Pro Met Asp Xaa Ile Phe Val Lys Gln Val Lys Glu Gly Gly Pro Ala 
            100                 105                 110         


Phe Glu Ala Gly Leu Cys Xaa Gly Asp Arg Ile Ile Lys Val Asn Gly 
        115                 120                 125             


Glu Ser Val Ile Gly Lys Xaa Tyr Ser Gln Val Ile Ala Leu Ile Gln 
    130                 135                 140                 


Asn Ser Asp Xaa Xaa Leu Glu Leu Ser Val Met Pro Lys Asp Glu Asp 
145                 150                 155                 160 


Ile Leu Gln Val Ala Tyr Ser Gln Asp Ala Tyr Leu Lys Gly Asn Glu 
                165                 170                 175     


Ala Tyr Ser Gly Asn Ala Arg Asn Ile Pro Glu Pro Pro Pro Ile Cys 
            180                 185                 190         


Tyr Pro Trp Leu Pro Ser Ala Pro Ser Ala Met Ala Gln Pro Val Glu 
        195                 200                 205             


Ile Ser Pro Pro Asp Ser Ser Leu Ser Lys Gln Gln Xaa Ser Xaa Pro 
    210                 215                 220                 


Val Leu Xaa Gln Pro Gly Arg Ala Tyr Arg Met Glu Ile Gln Val Pro 
225                 230                 235                 240 


Pro Ser Pro Xaa Asp Val Ala Lys Ser Asn Xaa Ala Val Cys Val Cys 
                245                 250                 255     


Asn Glu Ser Val Arg Xaa Val Ile Val Pro Ser Glu Lys Val Val Asp 
            260                 265                 270         


Leu Leu Ser Asn Arg Asn Asn His Xaa Gly Pro Ser His Arg Xaa Glu 
        275                 280                 285             


Glu Val Arg Tyr Gly Val Ser Glu Gln Xaa Ser Leu Lys Xaa Val Ser 
    290                 295                 300                 


Arg Xaa Xaa Ser Pro Pro Leu Ser Ile Pro Xaa Xaa His Leu Ile His 
305                 310                 315                 320 


Gln Pro Ala Gly Ser Arg Ser Leu Glu Pro Ser Gly Ile Leu Leu Lys 
                325                 330                 335     


Ser Gly Asn Tyr Ser Gly His Ser Asp Gly Ile Ser Ser Ser Arg Ser 
            340                 345                 350         


Gln Ala Val Glu Ala Pro Ser Val Ser Val Asn His Tyr Ser Pro Asn 
        355                 360                 365             


Ser His Gln His Ile Asp Trp Lys Asn Tyr Lys Xaa Tyr Lys Glu Tyr 
    370                 375                 380                 


Ile Asp Asn Arg Arg Leu His Ile Gly Cys Arg Xaa Ile Gln Glu Arg 
385                 390                 395                 400 


Leu Asp Ser Leu Arg Ala Ala Ser Gln Ser Xaa Xaa Asp Tyr Asn Gln 
                405                 410                 415     


Val Val Pro Asn Arg Xaa Xaa Leu Gln Gly Arg Arg Arg Ser Xaa Ser 
            420                 425                 430         


His Asp Arg Val Pro Gln Ser Val Gln Ile Arg Gln Arg Ser Val Ser 
        435                 440                 445             


Gln Glu Arg Leu Glu Asp Ser Val Leu Met Lys Tyr Cys Pro Arg Ser 
    450                 455                 460                 


Ala Ser Gln Gly Ala Leu Xaa Ser Pro Ser Val Ser Phe Ser Asn His 
465                 470                 475                 480 


Arg Xaa Arg Ser Trp Asp Tyr Ile Glu Gly Gln Asp Glu Xaa Leu Glu 
                485                 490                 495     


Asn Val Asn Ser Gly Xaa Pro Ile Pro Asp Ser Asn Gly Glu Lys Lys 
            500                 505                 510         


Gln Xaa Tyr Lys Trp Ser Gly Phe Xaa Glu Gln Asp Asp Arg Arg Gly 
        515                 520                 525             


Ile Cys Glu Arg Pro Arg Gln Gln Glu Ile His Lys Ser Phe Arg Gly 
    530                 535                 540                 


Ser Asn Phe Xaa Val Ala Pro Ser Val Val Asn Ser Asp Asn Arg Arg 
545                 550                 555                 560 


Met Ser Gly Arg Gly Val Gly Ser Val Ser Gln Phe Ser Ser Ile Pro 
                565                 570                 575     


Ser Ile Met Arg Lys Xaa Phe Glu Lys Lys Pro Xaa Ala Xaa Gly Xaa 
            580                 585                 590         


Phe Gly Val Arg Leu Asp Asp Cys Pro Pro Ala His Xaa Asn Arg Tyr 
        595                 600                 605             


Ile Pro Leu Ile Val Asp Ile Cys Cys Lys Leu Val Glu Glu Arg Gly 
    610                 615                 620                 


Leu Glu Tyr Xaa Gly Ile Tyr Arg Val Pro Gly Asn Asn Ala Ala Ile 
625                 630                 635                 640 


Ser Ser Met Gln Glu Glu Leu Asn Lys Gly Met Ala Asp Ile Asp Ile 
                645                 650                 655     


Gln Asp Asp Lys Trp Arg Asp Leu Asn Val Ile Ser Ser Leu Leu Lys 
            660                 665                 670         


Ser Phe Phe Arg Lys Leu Pro Glu Pro Leu Phe Xaa Asn Asp Lys Tyr 
        675                 680                 685             


Ala Asp Phe Ile Glu Ala Asn Arg Lys Glu Asp Pro Leu Asp Arg Leu 
    690                 695                 700                 


Lys Xaa Leu Lys Arg Leu Ile His Asp Leu Pro Glu His His Tyr Glu 
705                 710                 715                 720 


Xaa Leu Lys Phe Leu Ser Ala His Leu Lys Xaa Val Ala Glu Asn Ser 
                725                 730                 735     


Glu Lys Asn Lys Met Glu Pro Arg Asn Leu Ala Ile Val Phe Gly Pro 
            740                 745                 750         


Xaa Leu Val Arg Xaa Ser Glu Asp Asn Met Xaa His Met Val Xaa His 
        755                 760                 765             


Met Pro Asp Gln Tyr Lys Ile Val Glu Xaa Leu Ile Gln His His Asp 
    770                 775                 780                 


Trp Phe Phe Xaa Glu Glu Gly Ala Glu Glu Pro Leu Xaa Xaa Val Gln 
785                 790                 795                 800 


Glu Glu Ser Xaa Val Asp Ser Gln Pro Val Pro Asn Ile Asp His Leu 
                805                 810                 815     


Leu Xaa Asn Ile Gly Arg Xaa Gly Val Ser Pro Gly Asp Val Ser Asp 
            820                 825                 830         


Ser Ala Xaa Ser Asp Ser Xaa Lys Ser Lys Gly Ser Trp Gly Ser Gly 
        835                 840                 845             


Lys Asp Gln Tyr Ser Arg Glu Leu Leu Val Ser Ser Ile Phe Ala Ala 
    850                 855                 860                 


Ala Ser Arg Lys Arg Lys Lys Pro Lys Glu Lys Ala Gln Pro Ser Ser 
865                 870                 875                 880 


Ser Glu Asp Glu Leu Asp Asn Val Phe Phe Lys Lys Glu Asn Val Glu 
                885                 890                 895     


Gln Cys His Asn Asp Xaa Lys Glu Glu Ser Lys Lys Glu Ser Glu Xaa 
            900                 905                 910         


Leu Gly Arg Lys Gln Lys Ile Ile Ile Ala Lys Glu Asn Ser Xaa Arg 
        915                 920                 925             


Lys Asp Pro Ser Xaa Xaa Lys Asp Glu Lys Ile Ser Leu Gly Lys Glu 
    930                 935                 940                 


Ser Xaa Pro Ser Glu Glu Pro Ser Pro Pro His Asn Ser Lys His Asn 
945                 950                 955                 960 


Lys Ser Pro Xaa Leu Ser Cys Arg Phe Ala Ile Leu Lys Glu Ser Pro 
                965                 970                 975     


Arg Ser Leu Leu Ala Gln Lys Ser Ser His Leu Glu Glu Xaa Gly Ser 
            980                 985                 990         


Asp Ser Gly Xaa Leu Leu Ser Xaa  Ser Ser Gln Ala Ser  Leu Ala Arg 
        995                 1000                 1005             


Phe Ser  Met Lys Lys Ser Xaa  Ser Pro Glu Xaa Lys  His Ser Glu 
    1010                 1015                 1020             


Phe Leu  Ala Asn Val Ser Xaa  Ile Xaa Ser Asp Tyr  Ser Xaa Xaa 
    1025                 1030                 1035             


Ser Ser  Ala Xaa Tyr Leu Xaa  Ser Leu Asp Ser Ser  Arg Leu Ser 
    1040                 1045                 1050             


Pro Glu  Val Gln Ser Val Ala  Glu Ser Lys Gly Asp  Glu Ala Asp 
    1055                 1060                 1065             


Asp Glu  Arg Ser Glu Leu Ile  Ser Glu Gly Arg Pro  Val Glu Xaa 
    1070                 1075                 1080             


Asp Ser  Glu Ser Glu Phe Pro  Val Phe Pro Xaa Ala  Leu Xaa Ser 
    1085                 1090                 1095             


Glu Arg  Leu Phe Arg Gly Lys  Leu Gln Glu Val Xaa  Lys Ser Ser 
    1100                 1105                 1110             


Arg Arg  Asn Ser Glu Gly Ser  Glu Leu Ser Cys Xaa  Glu Gly Ser 
    1115                 1120                 1125             


Leu Xaa  Ser Ser Leu Asp Ser  Arg Arg Gln Leu Phe  Ser Ser His 
    1130                 1135                 1140             


Lys Leu  Ile Glu Cys Asp Xaa  Leu Ser Arg Lys Lys  Ser Ala Arg 
    1145                 1150                 1155             


Phe Lys  Ser Asp Ser Gly Ser  Leu Gly Asp Ala Lys  Asn Glu Lys 
    1160                 1165                 1170             


Glu Ala  Pro Ser Leu Xaa Lys  Val Phe Asp Val Met  Lys Lys Gly 
    1175                 1180                 1185             


Lys Ser  Xaa Gly Ser Leu Leu  Xaa Pro Xaa Arg Gly  Glu Ser Glu 
    1190                 1195                 1200             


Lys Gln  Glu Pro Xaa Trp Lys  Xaa Lys Ile Ala Asp  Arg Leu Lys 
    1205                 1210                 1215             


Leu Arg  Pro Arg Ala Pro Ala  Asp Asp Met Phe Gly  Val Gly Asn 
    1220                 1225                 1230             


His Lys  Val Asn Ala Glu Xaa  Ala Lys Arg Lys Ser  Ile Arg Arg 
    1235                 1240                 1245             


Arg His  Xaa Leu Gly Gly His  Arg Asp Ala Xaa Glu  Ile Ser Val 
    1250                 1255                 1260             


Leu Asn  Phe Trp Lys Val His  Glu Gln Ser Gly Glu  Arg Glu Ser 
    1265                 1270                 1275             


Glu Leu  Ser Ala Val Asn Arg  Leu Lys Pro Lys Cys  Ser Ala Gln 
    1280                 1285                 1290             


Asp Leu  Ser Ile Ser Asp Trp  Leu Ala Arg Glu Arg  Leu Arg Xaa 
    1295                 1300                 1305             


Ser Xaa  Ser Asp Leu Ser Arg  Gly Glu Ile Gly Asp  Pro Gln Xaa 
    1310                 1315                 1320             


Glu Asn  Pro Ser Xaa Arg Glu  Ile Ala Xaa Xaa Asp  Xaa Pro Leu 
    1325                 1330                 1335             


Ser Leu  His Cys Asn Xaa Gly  Ser Ser Ser Ser Xaa  Leu Ala Ser 
    1340                 1345                 1350             


Xaa Asn  Arg Pro Leu Leu Ser  Ile Pro Pro Gln Ser  Pro Asp Gln 
    1355                 1360                 1365             


Ile Asn  Gly Glu Ser Phe Gln  Asn Val Ser Lys Asn  Ala Ser Ser 
    1370                 1375                 1380             


Ala Ala  Asn Ala Gln Pro His  Lys Leu Ser Glu Xaa  Pro Gly Ser 
    1385                 1390                 1395             


Lys Ala  Glu Phe His Pro Cys  Leu 
    1400                 1405     


<210> 2751
<211> 1407
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1131)..(1131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1197)..(1197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1252)..(1252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1260)..(1260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1324)..(1324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1355)..(1355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1396)..(1396)
<223> Selenocysteine

<400> 2751
Met Ala Xaa Arg Arg Xaa Gly Leu Ser Glu Gly Asp Gly Asp Lys Leu 
1               5                   10                  15      


Lys Ala Cys Glu Val Ser Lys Asn Lys Asp Gly Lys Glu Gln Ser Glu 
            20                  25                  30          


Xaa Val Ser Leu Ser Glu Asp Glu Xaa Phe Ser Trp Pro Gly Pro Lys 
        35                  40                  45              


Xaa Val Xaa Leu Lys Arg Xaa Ser Gln Gly Phe Gly Phe Xaa Leu Arg 
    50                  55                  60                  


His Phe Ile Val Tyr Pro Pro Glu Ser Ala Ile Gln Phe Ser Tyr Lys 
65                  70                  75                  80  


Asp Glu Glu Asn Gly Asn Arg Gly Gly Lys Gln Arg Asn Arg Leu Glu 
                85                  90                  95      


Pro Met Asp Xaa Ile Phe Val Lys Gln Val Lys Glu Gly Gly Pro Ala 
            100                 105                 110         


Phe Glu Ala Gly Leu Cys Xaa Gly Asp Arg Ile Ile Lys Val Asn Gly 
        115                 120                 125             


Glu Ser Val Ile Gly Lys Xaa Tyr Ser Gln Val Ile Ala Leu Ile Gln 
    130                 135                 140                 


Asn Ser Asp Xaa Xaa Leu Glu Leu Ser Val Met Pro Lys Asp Glu Asp 
145                 150                 155                 160 


Ile Leu Gln Val Ala Tyr Ser Gln Asp Ala Tyr Leu Lys Gly Asn Glu 
                165                 170                 175     


Ala Tyr Ser Gly Asn Ala Arg Asn Ile Pro Glu Pro Pro Pro Ile Cys 
            180                 185                 190         


Tyr Pro Trp Leu Pro Ser Ala Pro Ser Ala Met Ala Gln Pro Val Glu 
        195                 200                 205             


Ile Ser Pro Pro Asp Ser Ser Leu Ser Lys Gln Gln Xaa Ser Xaa Pro 
    210                 215                 220                 


Val Leu Xaa Gln Pro Gly Arg Ala Tyr Arg Met Glu Ile Gln Val Pro 
225                 230                 235                 240 


Pro Ser Pro Xaa Asp Val Ala Lys Ser Asn Xaa Ala Val Cys Val Cys 
                245                 250                 255     


Asn Glu Ser Val Arg Xaa Val Ile Val Pro Ser Glu Lys Val Val Asp 
            260                 265                 270         


Leu Leu Ser Asn Arg Asn Asn His Xaa Gly Pro Ser His Arg Xaa Glu 
        275                 280                 285             


Glu Val Arg Tyr Gly Val Ser Glu Gln Xaa Ser Leu Lys Xaa Val Ser 
    290                 295                 300                 


Arg Xaa Xaa Ser Pro Pro Leu Ser Ile Pro Xaa Xaa His Leu Ile His 
305                 310                 315                 320 


Gln Pro Ala Gly Ser Arg Ser Leu Glu Pro Ser Gly Ile Leu Leu Lys 
                325                 330                 335     


Ser Gly Asn Tyr Ser Gly His Ser Asp Gly Ile Ser Ser Ser Arg Ser 
            340                 345                 350         


Gln Ala Val Glu Ala Pro Ser Val Ser Val Asn His Tyr Ser Pro Asn 
        355                 360                 365             


Ser His Gln His Ile Asp Trp Lys Asn Tyr Lys Xaa Tyr Lys Glu Tyr 
    370                 375                 380                 


Ile Asp Asn Arg Arg Leu His Ile Gly Cys Arg Xaa Ile Gln Glu Arg 
385                 390                 395                 400 


Leu Asp Ser Leu Arg Ala Ala Ser Gln Ser Xaa Xaa Asp Tyr Asn Gln 
                405                 410                 415     


Val Val Pro Asn Arg Xaa Xaa Leu Gln Gly Arg Arg Arg Ser Xaa Ser 
            420                 425                 430         


His Asp Arg Val Pro Gln Ser Val Gln Ile Arg Gln Arg Ser Val Ser 
        435                 440                 445             


Gln Glu Arg Leu Glu Asp Ser Val Leu Met Lys Tyr Cys Pro Arg Ser 
    450                 455                 460                 


Ala Ser Gln Gly Ala Leu Xaa Ser Pro Ser Val Ser Phe Ser Asn His 
465                 470                 475                 480 


Arg Xaa Arg Ser Trp Asp Tyr Ile Glu Gly Gln Asp Glu Xaa Leu Glu 
                485                 490                 495     


Asn Val Asn Ser Gly Xaa Pro Ile Pro Asp Ser Asn Gly Glu Lys Lys 
            500                 505                 510         


Gln Xaa Tyr Lys Trp Ser Gly Phe Xaa Glu Gln Asp Asp Arg Arg Gly 
        515                 520                 525             


Ile Cys Glu Arg Pro Arg Gln Gln Glu Ile His Lys Ser Phe Arg Gly 
    530                 535                 540                 


Ser Asn Phe Xaa Val Ala Pro Ser Val Val Asn Ser Asp Asn Arg Arg 
545                 550                 555                 560 


Met Ser Gly Arg Gly Val Gly Ser Val Ser His Trp Arg Lys Gly Ile 
                565                 570                 575     


Pro Ser Ile Met Arg Lys Xaa Phe Glu Lys Lys Pro Xaa Ala Xaa Gly 
            580                 585                 590         


Xaa Phe Gly Val Arg Leu Asp Asp Cys Pro Pro Ala His Xaa Asn Arg 
        595                 600                 605             


Tyr Ile Pro Leu Ile Val Asp Ile Cys Cys Lys Leu Val Glu Glu Arg 
    610                 615                 620                 


Gly Leu Glu Tyr Xaa Gly Ile Tyr Arg Val Pro Gly Asn Asn Ala Ala 
625                 630                 635                 640 


Ile Ser Ser Met Gln Glu Glu Leu Asn Lys Gly Met Ala Asp Ile Asp 
                645                 650                 655     


Ile Gln Asp Asp Lys Trp Arg Asp Leu Asn Val Ile Ser Ser Leu Leu 
            660                 665                 670         


Lys Ser Phe Phe Arg Lys Leu Pro Glu Pro Leu Phe Xaa Asn Asp Lys 
        675                 680                 685             


Tyr Ala Asp Phe Ile Glu Ala Asn Arg Lys Glu Asp Pro Leu Asp Arg 
    690                 695                 700                 


Leu Lys Xaa Leu Lys Arg Leu Ile His Asp Leu Pro Glu His His Tyr 
705                 710                 715                 720 


Glu Xaa Leu Lys Phe Leu Ser Ala His Leu Lys Xaa Val Ala Glu Asn 
                725                 730                 735     


Ser Glu Lys Asn Lys Met Glu Pro Arg Asn Leu Ala Ile Val Phe Gly 
            740                 745                 750         


Pro Xaa Leu Val Arg Xaa Ser Glu Asp Asn Met Xaa His Met Val Xaa 
        755                 760                 765             


His Met Pro Asp Gln Tyr Lys Ile Val Glu Xaa Leu Ile Gln His His 
    770                 775                 780                 


Asp Trp Phe Phe Xaa Glu Glu Gly Ala Glu Glu Pro Leu Xaa Xaa Val 
785                 790                 795                 800 


Gln Glu Glu Ser Xaa Val Asp Ser Gln Pro Val Pro Asn Ile Asp His 
                805                 810                 815     


Leu Leu Xaa Asn Ile Gly Arg Xaa Gly Val Ser Pro Gly Asp Val Ser 
            820                 825                 830         


Asp Ser Ala Xaa Ser Asp Ser Xaa Lys Ser Lys Gly Ser Trp Gly Ser 
        835                 840                 845             


Gly Lys Asp Gln Tyr Ser Arg Glu Leu Leu Val Ser Ser Ile Phe Ala 
    850                 855                 860                 


Ala Ala Ser Arg Lys Arg Lys Lys Pro Lys Glu Lys Ala Gln Pro Ser 
865                 870                 875                 880 


Ser Ser Glu Asp Glu Leu Asp Asn Val Phe Phe Lys Lys Glu Asn Val 
                885                 890                 895     


Glu Gln Cys His Asn Asp Xaa Lys Glu Glu Ser Lys Lys Glu Ser Glu 
            900                 905                 910         


Xaa Leu Gly Arg Lys Gln Lys Ile Ile Ile Ala Lys Glu Asn Ser Xaa 
        915                 920                 925             


Arg Lys Asp Pro Ser Xaa Xaa Lys Asp Glu Lys Ile Ser Leu Gly Lys 
    930                 935                 940                 


Glu Ser Xaa Pro Ser Glu Glu Pro Ser Pro Pro His Asn Ser Lys His 
945                 950                 955                 960 


Asn Lys Ser Pro Xaa Leu Ser Cys Arg Phe Ala Ile Leu Lys Glu Ser 
                965                 970                 975     


Pro Arg Ser Leu Leu Ala Gln Lys Ser Ser His Leu Glu Glu Xaa Gly 
            980                 985                 990         


Ser Asp Ser Gly Xaa Leu Leu Ser  Xaa Ser Ser Gln Ala  Ser Leu Ala 
        995                 1000                 1005             


Arg Phe  Ser Met Lys Lys Ser  Xaa Ser Pro Glu Xaa  Lys His Ser 
    1010                 1015                 1020             


Glu Phe  Leu Ala Asn Val Ser  Xaa Ile Xaa Ser Asp  Tyr Ser Xaa 
    1025                 1030                 1035             


Xaa Ser  Ser Ala Xaa Tyr Leu  Xaa Ser Leu Asp Ser  Ser Arg Leu 
    1040                 1045                 1050             


Ser Pro  Glu Val Gln Ser Val  Ala Glu Ser Lys Gly  Asp Glu Ala 
    1055                 1060                 1065             


Asp Asp  Glu Arg Ser Glu Leu  Ile Ser Glu Gly Arg  Pro Val Glu 
    1070                 1075                 1080             


Xaa Asp  Ser Glu Ser Glu Phe  Pro Val Phe Pro Xaa  Ala Leu Xaa 
    1085                 1090                 1095             


Ser Glu  Arg Leu Phe Arg Gly  Lys Leu Gln Glu Val  Xaa Lys Ser 
    1100                 1105                 1110             


Ser Arg  Arg Asn Ser Glu Gly  Ser Glu Leu Ser Cys  Xaa Glu Gly 
    1115                 1120                 1125             


Ser Leu  Xaa Ser Ser Leu Asp  Ser Arg Arg Gln Leu  Phe Ser Ser 
    1130                 1135                 1140             


His Lys  Leu Ile Glu Cys Asp  Xaa Leu Ser Arg Lys  Lys Ser Ala 
    1145                 1150                 1155             


Arg Phe  Lys Ser Asp Ser Gly  Ser Leu Gly Asp Ala  Lys Asn Glu 
    1160                 1165                 1170             


Lys Glu  Ala Pro Ser Leu Xaa  Lys Val Phe Asp Val  Met Lys Lys 
    1175                 1180                 1185             


Gly Lys  Ser Xaa Gly Ser Leu  Leu Xaa Pro Xaa Arg  Gly Glu Ser 
    1190                 1195                 1200             


Glu Lys  Gln Glu Pro Xaa Trp  Lys Xaa Lys Ile Ala  Asp Arg Leu 
    1205                 1210                 1215             


Lys Leu  Arg Pro Arg Ala Pro  Ala Asp Asp Met Phe  Gly Val Gly 
    1220                 1225                 1230             


Asn His  Lys Val Asn Ala Glu  Xaa Ala Lys Arg Lys  Ser Ile Arg 
    1235                 1240                 1245             


Arg Arg  His Xaa Leu Gly Gly  His Arg Asp Ala Xaa  Glu Ile Ser 
    1250                 1255                 1260             


Val Leu  Asn Phe Trp Lys Val  His Glu Gln Ser Gly  Glu Arg Glu 
    1265                 1270                 1275             


Ser Glu  Leu Ser Ala Val Asn  Arg Leu Lys Pro Lys  Cys Ser Ala 
    1280                 1285                 1290             


Gln Asp  Leu Ser Ile Ser Asp  Trp Leu Ala Arg Glu  Arg Leu Arg 
    1295                 1300                 1305             


Xaa Ser  Xaa Ser Asp Leu Ser  Arg Gly Glu Ile Gly  Asp Pro Gln 
    1310                 1315                 1320             


Xaa Glu  Asn Pro Ser Xaa Arg  Glu Ile Ala Xaa Xaa  Asp Xaa Pro 
    1325                 1330                 1335             


Leu Ser  Leu His Cys Asn Xaa  Gly Ser Ser Ser Ser  Xaa Leu Ala 
    1340                 1345                 1350             


Ser Xaa  Asn Arg Pro Leu Leu  Ser Ile Pro Pro Gln  Ser Pro Asp 
    1355                 1360                 1365             


Gln Ile  Asn Gly Glu Ser Phe  Gln Asn Val Ser Lys  Asn Ala Ser 
    1370                 1375                 1380             


Ser Ala  Ala Asn Ala Gln Pro  His Lys Leu Ser Glu  Xaa Pro Gly 
    1385                 1390                 1395             


Ser Lys  Ala Glu Phe His Pro  Cys Leu 
    1400                 1405         


<210> 2752
<211> 1165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<400> 2752
Met Met Ala Xaa Arg Arg Xaa Gly Leu Ser Glu Gly Asp Gly Asp Lys 
1               5                   10                  15      


Leu Lys Ala Cys Glu Val Ser Lys Asn Lys Asp Gly Lys Glu Gln Ser 
            20                  25                  30          


Glu Xaa Val Ser Leu Ser Glu Asp Glu Xaa Phe Ser Trp Pro Gly Pro 
        35                  40                  45              


Lys Xaa Val Xaa Leu Lys Arg Xaa Ser Gln Gly Phe Gly Phe Xaa Leu 
    50                  55                  60                  


Arg His Phe Ile Val Tyr Pro Pro Glu Ser Ala Ile Gln Phe Ser Tyr 
65                  70                  75                  80  


Lys Asp Glu Glu Asn Gly Asn Arg Gly Gly Lys Gln Arg Asn Arg Leu 
                85                  90                  95      


Glu Pro Met Asp Xaa Ile Phe Val Lys Gln Val Lys Glu Gly Gly Pro 
            100                 105                 110         


Ala Phe Glu Ala Gly Leu Cys Xaa Gly Asp Arg Ile Ile Lys Val Asn 
        115                 120                 125             


Gly Glu Ser Val Ile Gly Lys Xaa Tyr Ser Gln Val Ile Ala Leu Ile 
    130                 135                 140                 


Gln Asn Ser Asp Xaa Xaa Leu Glu Leu Ser Val Met Pro Lys Asp Glu 
145                 150                 155                 160 


Asp Ile Leu Gln Val Ala Tyr Ser Gln Asp Ala Tyr Leu Lys Gly Asn 
                165                 170                 175     


Glu Ala Tyr Ser Gly Asn Ala Arg Asn Ile Pro Glu Pro Pro Pro Ile 
            180                 185                 190         


Cys Tyr Pro Trp Leu Pro Ser Ala Pro Ser Ala Met Ala Gln Pro Val 
        195                 200                 205             


Glu Ile Ser Pro Pro Asp Ser Ser Leu Ser Lys Gln Gln Xaa Ser Xaa 
    210                 215                 220                 


Pro Val Leu Xaa Gln Pro Gly Arg Ala Tyr Arg Met Glu Ile Gln Val 
225                 230                 235                 240 


Pro Pro Ser Pro Xaa Asp Val Ala Lys Ser Asn Xaa Ala Val Cys Val 
                245                 250                 255     


Cys Asn Glu Ser Val Arg Xaa Val Ile Val Pro Ser Glu Lys Val Val 
            260                 265                 270         


Asp Leu Leu Ser Asn Arg Asn Asn His Xaa Gly Pro Ser His Arg Xaa 
        275                 280                 285             


Glu Glu Val Arg Tyr Gly Val Ser Glu Gln Xaa Ser Leu Lys Xaa Val 
    290                 295                 300                 


Ser Arg Xaa Xaa Ser Pro Pro Leu Ser Ile Pro Xaa Xaa His Leu Ile 
305                 310                 315                 320 


His Gln Pro Ala Gly Ser Arg Ser Leu Glu Pro Ser Gly Ile Leu Leu 
                325                 330                 335     


Lys Ser Gly Asn Tyr Ser Gly His Ser Asp Gly Ile Ser Ser Ser Arg 
            340                 345                 350         


Ser Gln Ala Val Glu Ala Pro Ser Val Ser Val Asn His Tyr Ser Pro 
        355                 360                 365             


Asn Ser His Gln His Ile Asp Trp Lys Asn Tyr Lys Xaa Tyr Lys Glu 
    370                 375                 380                 


Tyr Ile Asp Asn Arg Arg Leu His Ile Gly Cys Arg Xaa Ile Gln Glu 
385                 390                 395                 400 


Arg Leu Asp Ser Leu Arg Ala Ala Ser Gln Ser Xaa Xaa Asp Tyr Asn 
                405                 410                 415     


Gln Val Val Pro Asn Arg Xaa Xaa Leu Gln Gly Arg Arg Arg Ser Xaa 
            420                 425                 430         


Ser His Asp Arg Val Pro Gln Ser Val Gln Ile Arg Gln Arg Ser Val 
        435                 440                 445             


Ser Gln Glu Arg Leu Glu Asp Ser Val Leu Met Lys Tyr Cys Pro Arg 
    450                 455                 460                 


Ser Ala Ser Gln Gly Ala Leu Xaa Ser Pro Ser Val Ser Phe Ser Asn 
465                 470                 475                 480 


His Arg Xaa Arg Ser Trp Asp Tyr Ile Glu Gly Gln Asp Glu Xaa Leu 
                485                 490                 495     


Glu Asn Val Asn Ser Gly Xaa Pro Ile Pro Asp Ser Asn Gly Glu Lys 
            500                 505                 510         


Lys Gln Xaa Tyr Lys Trp Ser Gly Phe Xaa Glu Gln Asp Asp Arg Arg 
        515                 520                 525             


Gly Ile Cys Glu Arg Pro Arg Gln Gln Glu Ile His Lys Ser Phe Arg 
    530                 535                 540                 


Gly Ser Asn Phe Xaa Val Ala Pro Ser Val Val Asn Ser Asp Asn Arg 
545                 550                 555                 560 


Arg Met Ser Gly Arg Gly Val Gly Ser Val Ser Gln Phe Lys Lys Ile 
                565                 570                 575     


Pro Pro Asp Leu Lys Xaa Leu Gln Ser Asn Arg Asn Phe Gln Xaa Xaa 
            580                 585                 590         


Cys Gly Met Ser Leu Pro Arg Gly Ile Ser Gln Asp Arg Ser Pro Leu 
        595                 600                 605             


Val Lys Val Arg Ser Asn Ser Leu Lys Ala Pro Ser Xaa His Val Xaa 
    610                 615                 620                 


Lys Pro Ser Phe Ser Gln Lys Ser Phe Val Ser Ile Lys Asp Gln Arg 
625                 630                 635                 640 


Pro Val Asn His Leu His Gln Asn Ser Leu Leu Asn Gln Gln Xaa Trp 
                645                 650                 655     


Val Arg Xaa Asp Ser Ala Pro Asp Gln Gln Val Glu Xaa Gly Lys Ser 
            660                 665                 670         


Pro Ser Leu Ser Gly Ala Ser Ala Lys Pro Ala Pro Gln Ser Ser Glu 
        675                 680                 685             


Asn Ala Gly Xaa Ser Asp Leu Glu Leu Pro Val Ser Gln Arg Asn Gln 
    690                 695                 700                 


Asp Leu Ser Leu Gln Glu Ala Glu Xaa Glu Gln Ser Asp Xaa Leu Asp 
705                 710                 715                 720 


Asn Lys Glu Ala Val Ile Leu Arg Glu Lys Pro Pro Ser Gly Arg Gln 
                725                 730                 735     


Xaa Pro Gln Pro Leu Arg His Gln Ser Tyr Ile Leu Ala Val Asn Asp 
            740                 745                 750         


Gln Glu Xaa Gly Ser Asp Xaa Xaa Cys Trp Leu Pro Asn Asp Ala Arg 
        755                 760                 765             


Arg Glu Val His Ile Lys Arg Met Glu Glu Arg Lys Ala Ser Ser Xaa 
    770                 775                 780                 


Ser Pro Pro Gly Asp Ser Leu Ala Ser Ile Pro Phe Ile Asp Glu Pro 
785                 790                 795                 800 


Xaa Ser Pro Ser Ile Asp His Asp Ile Ala His Ile Pro Ala Ser Ala 
                805                 810                 815     


Val Ile Ser Ala Ser Xaa Ser Gln Val Pro Ser Ile Ala Xaa Val Pro 
            820                 825                 830         


Pro Cys Leu Xaa Xaa Ser Ala Pro Leu Ile Arg Arg Gln Leu Ser His 
        835                 840                 845             


Asp His Glu Ser Val Gly Pro Pro Ser Leu Asp Ala Gln Pro Asn Ser 
    850                 855                 860                 


Lys Xaa Glu Arg Ser Lys Ser Tyr Asp Glu Gly Leu Asp Asp Tyr Arg 
865                 870                 875                 880 


Glu Asp Ala Lys Leu Ser Phe Lys His Val Ser Ser Leu Lys Gly Ile 
                885                 890                 895     


Lys Ile Ala Asp Ser Gln Lys Ser Ser Glu Asp Ser Gly Ser Arg Lys 
            900                 905                 910         


Asp Ser Ser Ser Glu Val Phe Ser Asp Ala Ala Lys Glu Gly Trp Leu 
        915                 920                 925             


His Phe Arg Pro Leu Val Xaa Asp Lys Gly Lys Arg Val Gly Gly Ser 
    930                 935                 940                 


Ile Arg Pro Trp Lys Gln Met Tyr Val Val Leu Arg Gly His Ser Leu 
945                 950                 955                 960 


Tyr Leu Tyr Lys Asp Lys Arg Glu Gln Xaa Xaa Pro Ser Glu Glu Glu 
                965                 970                 975     


Gln Pro Ile Ser Val Asn Ala Cys Leu Ile Asp Ile Ser Tyr Ser Glu 
            980                 985                 990         


Xaa Lys Arg Lys Asn Val Phe Arg  Leu Xaa Xaa Ser Asp  Cys Glu Cys 
        995                 1000                 1005             


Leu Phe  Gln Ala Glu Asp Arg  Asp Asp Met Leu Ala  Trp Ile Lys 
    1010                 1015                 1020             


Xaa Ile  Gln Glu Ser Ser Asn  Leu Asn Glu Glu Asp  Xaa Gly Val 
    1025                 1030                 1035             


Xaa Asn  Arg Asp Leu Ile Ser  Arg Arg Ile Lys Glu  Tyr Asn Asn 
    1040                 1045                 1050             


Leu Met  Ser Lys Ala Glu Gln  Leu Pro Lys Xaa Pro  Arg Gln Ser 
    1055                 1060                 1065             


Leu Ser  Ile Arg Gln Xaa Leu  Leu Gly Ala Lys Ser  Glu Pro Lys 
    1070                 1075                 1080             


Xaa Gln  Ser Pro His Ser Pro  Lys Glu Glu Ser Glu  Arg Lys Leu 
    1085                 1090                 1095             


Leu Ser  Lys Asp Asp Xaa Ser  Pro Pro Lys Asp Lys  Gly Xaa Trp 
    1100                 1105                 1110             


Arg Lys  Gly Ile Pro Ser Ile  Met Arg Lys Xaa Phe  Glu Lys Lys 
    1115                 1120                 1125             


Pro Xaa  Ala Xaa Gly Xaa Phe  Gly Val Arg Leu Asp  Asp Cys Pro 
    1130                 1135                 1140             


Pro Ala  His Xaa Asn Arg Val  Gly Asp Xaa Ser Pro  Pro Asp Phe 
    1145                 1150                 1155             


Leu Lys  Ser Leu Ile Gln Phe  
    1160                 1165 


<210> 2753
<211> 1131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<400> 2753
Met Met Ala Xaa Arg Arg Xaa Gly Leu Ser Glu Gly Asp Gly Asp Lys 
1               5                   10                  15      


Leu Lys Ala Cys Glu Val Ser Lys Asn Lys Asp Gly Lys Glu Gln Ser 
            20                  25                  30          


Glu Xaa Val Ser Leu Ser Glu Asp Glu Xaa Phe Ser Trp Pro Gly Pro 
        35                  40                  45              


Lys Xaa Val Xaa Leu Lys Arg Xaa Ser Gln Gly Phe Gly Phe Xaa Leu 
    50                  55                  60                  


Arg His Phe Ile Val Tyr Pro Pro Glu Ser Ala Ile Gln Phe Ser Tyr 
65                  70                  75                  80  


Lys Asp Glu Glu Asn Gly Asn Arg Gly Gly Lys Gln Arg Asn Arg Leu 
                85                  90                  95      


Glu Pro Met Asp Xaa Ile Phe Val Lys Gln Val Lys Glu Gly Gly Pro 
            100                 105                 110         


Ala Phe Glu Ala Gly Leu Cys Xaa Gly Asp Arg Ile Ile Lys Val Asn 
        115                 120                 125             


Gly Glu Ser Val Ile Gly Lys Xaa Tyr Ser Gln Val Ile Ala Leu Ile 
    130                 135                 140                 


Gln Asn Ser Asp Xaa Xaa Leu Glu Leu Ser Val Met Pro Lys Asp Glu 
145                 150                 155                 160 


Asp Ile Leu Gln Val Leu Gln Phe Xaa Lys Asp Val Xaa Ala Leu Ala 
                165                 170                 175     


Tyr Ser Gln Asp Ala Tyr Leu Lys Gly Asn Glu Ala Tyr Ser Gly Asn 
            180                 185                 190         


Ala Arg Asn Ile Pro Glu Pro Pro Pro Ile Cys Tyr Pro Trp Leu Pro 
        195                 200                 205             


Ser Ala Pro Ser Ala Met Ala Gln Pro Val Glu Ile Ser Pro Pro Asp 
    210                 215                 220                 


Ser Ser Leu Ser Lys Gln Gln Xaa Ser Xaa Pro Val Leu Xaa Gln Pro 
225                 230                 235                 240 


Gly Arg Ala Tyr Arg Met Glu Ile Gln Val Pro Pro Ser Pro Xaa Asp 
                245                 250                 255     


Val Ala Lys Ser Asn Xaa Ala Val Cys Val Cys Asn Glu Ser Val Arg 
            260                 265                 270         


Xaa Val Ile Val Pro Ser Glu Lys Val Val Asp Leu Leu Ser Asn Arg 
        275                 280                 285             


Asn Asn His Xaa Gly Pro Ser His Arg Xaa Glu Glu Val Arg Tyr Gly 
    290                 295                 300                 


Val Ser Glu Gln Xaa Ser Leu Lys Xaa Val Ser Arg Xaa Xaa Ser Pro 
305                 310                 315                 320 


Pro Leu Ser Ile Pro Xaa Xaa His Leu Ile His Gln Pro Ala Gly Ser 
                325                 330                 335     


Arg Ser Leu Glu Pro Ser Gly Ile Leu Leu Lys Ser Gly Asn Tyr Ser 
            340                 345                 350         


Gly His Ser Asp Gly Ile Ser Ser Ser Arg Ser Gln Ala Val Glu Ala 
        355                 360                 365             


Pro Ser Val Ser Val Asn His Tyr Ser Pro Asn Ser His Gln His Ile 
    370                 375                 380                 


Asp Trp Lys Asn Tyr Lys Xaa Tyr Lys Glu Tyr Ile Asp Asn Arg Arg 
385                 390                 395                 400 


Leu His Ile Gly Cys Arg Xaa Ile Gln Glu Arg Leu Asp Ser Leu Arg 
                405                 410                 415     


Ala Ala Ser Gln Ser Xaa Xaa Asp Tyr Asn Gln Val Val Pro Asn Arg 
            420                 425                 430         


Xaa Xaa Leu Gln Gly Arg Arg Arg Ser Xaa Ser His Asp Arg Val Pro 
        435                 440                 445             


Gln Ser Val Gln Ile Arg Gln Arg Ser Val Ser Gln Glu Arg Leu Glu 
    450                 455                 460                 


Asp Ser Val Leu Met Lys Tyr Cys Pro Arg Ser Ala Ser Gln Gly Ala 
465                 470                 475                 480 


Leu Xaa Ser Pro Ser Val Ser Phe Ser Asn His Arg Xaa Arg Ser Trp 
                485                 490                 495     


Asp Tyr Ile Glu Gly Gln Asp Glu Xaa Leu Glu Asn Val Asn Ser Gly 
            500                 505                 510         


Xaa Pro Ile Pro Asp Ser Asn Gly Glu Lys Lys Gln Xaa Tyr Lys Trp 
        515                 520                 525             


Ser Gly Phe Xaa Glu Gln Asp Asp Arg Arg Gly Ile Cys Glu Arg Pro 
    530                 535                 540                 


Arg Gln Gln Glu Ile His Lys Ser Phe Arg Gly Ser Asn Phe Xaa Val 
545                 550                 555                 560 


Ala Pro Ser Val Val Asn Ser Asp Asn Arg Arg Met Ser Gly Arg Gly 
                565                 570                 575     


Val Gly Ser Val Ser Gln Phe Lys Lys Ile Pro Pro Asp Leu Lys Xaa 
            580                 585                 590         


Leu Gln Ser Asn Arg Asn Phe Gln Xaa Xaa Cys Gly Met Ser Leu Pro 
        595                 600                 605             


Arg Gly Ile Ser Gln Asp Arg Ser Pro Leu Val Lys Val Arg Ser Asn 
    610                 615                 620                 


Ser Leu Lys Ala Pro Ser Xaa His Val Xaa Lys Pro Ser Phe Ser Gln 
625                 630                 635                 640 


Lys Ser Phe Val Ser Ile Lys Asp Gln Arg Pro Val Asn His Leu His 
                645                 650                 655     


Gln Asn Ser Leu Leu Asn Gln Gln Xaa Trp Val Arg Xaa Asp Ser Ala 
            660                 665                 670         


Pro Asp Gln Gln Val Glu Xaa Gly Lys Ser Pro Ser Leu Ser Gly Ala 
        675                 680                 685             


Ser Ala Lys Pro Ala Pro Gln Ser Ser Glu Asn Ala Gly Xaa Ser Asp 
    690                 695                 700                 


Leu Glu Leu Pro Val Ser Gln Arg Asn Gln Asp Leu Ser Leu Gln Glu 
705                 710                 715                 720 


Ala Glu Xaa Glu Gln Ser Asp Xaa Leu Asp Asn Lys Glu Ala Val Ile 
                725                 730                 735     


Leu Arg Glu Lys Pro Pro Ser Gly Arg Gln Xaa Pro Gln Pro Leu Arg 
            740                 745                 750         


His Gln Ser Tyr Ile Leu Ala Val Asn Asp Gln Glu Xaa Gly Ser Asp 
        755                 760                 765             


Xaa Xaa Cys Trp Leu Pro Asn Asp Ala Arg Arg Glu Val His Ile Lys 
    770                 775                 780                 


Arg Met Glu Glu Arg Lys Ala Ser Ser Xaa Ser Pro Pro Gly Asp Ser 
785                 790                 795                 800 


Leu Ala Ser Ile Pro Phe Ile Asp Glu Pro Xaa Ser Pro Ser Ile Asp 
                805                 810                 815     


His Asp Ile Ala His Ile Pro Ala Ser Ala Val Ile Ser Ala Ser Xaa 
            820                 825                 830         


Ser Gln Val Pro Ser Ile Ala Xaa Val Pro Pro Cys Leu Xaa Xaa Ser 
        835                 840                 845             


Ala Pro Leu Ile Arg Arg Gln Leu Ser His Asp His Glu Ser Val Gly 
    850                 855                 860                 


Pro Pro Ser Leu Asp Ala Gln Pro Asn Ser Lys Xaa Glu Arg Ser Lys 
865                 870                 875                 880 


Ser Tyr Asp Glu Gly Leu Asp Asp Tyr Arg Glu Asp Ala Lys Leu Ser 
                885                 890                 895     


Phe Lys His Val Ser Ser Leu Lys Gly Ile Lys Ile Ala Asp Ser Gln 
            900                 905                 910         


Lys Ser Ser Glu Asp Ser Gly Ser Arg Lys Asp Ser Ser Ser Glu Val 
        915                 920                 925             


Phe Ser Asp Ala Ala Lys Glu Gly Trp Leu His Phe Arg Pro Leu Val 
    930                 935                 940                 


Xaa Asp Lys Gly Lys Arg Val Gly Gly Ser Ile Arg Pro Trp Lys Gln 
945                 950                 955                 960 


Met Tyr Val Val Leu Arg Gly His Ser Leu Tyr Leu Tyr Lys Asp Lys 
                965                 970                 975     


Arg Glu Gln Xaa Xaa Pro Ser Glu Glu Glu Gln Pro Ile Ser Val Asn 
            980                 985                 990         


Ala Cys Leu Ile Asp Ile Ser Tyr  Ser Glu Xaa Lys Arg  Lys Asn Val 
        995                 1000                 1005             


Phe Arg  Leu Xaa Xaa Ser Asp  Cys Glu Cys Leu Phe  Gln Ala Glu 
    1010                 1015                 1020             


Asp Arg  Asp Asp Met Leu Ala  Trp Ile Lys Xaa Ile  Gln Glu Ser 
    1025                 1030                 1035             


Ser Asn  Leu Asn Glu Glu Asp  Xaa Gly Val Xaa Asn  Arg Asp Leu 
    1040                 1045                 1050             


Ile Ser  Arg Arg Ile Lys Glu  Tyr Asn Asn Leu Met  Ser Lys Ala 
    1055                 1060                 1065             


Glu Gln  Leu Pro Lys Xaa Pro  Arg Gln Ser Leu Ser  Ile Arg Gln 
    1070                 1075                 1080             


Xaa Leu  Leu Gly Ala Lys Ser  Glu Pro Lys Xaa Gln  Ser Pro His 
    1085                 1090                 1095             


Ser Pro  Lys Glu Glu Ser Glu  Arg Lys Leu Leu Ser  Lys Asp Asp 
    1100                 1105                 1110             


Xaa Ser  Pro Pro Lys Asp Lys  Gly Xaa Trp Arg Lys  Gly Ile Pro 
    1115                 1120                 1125             


Ser Ile  Met 
    1130     


<210> 2754
<211> 1958
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1273)..(1273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1315)..(1315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1319)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1330)..(1330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1340)..(1340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1349)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1356)..(1356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1375)..(1375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1387)..(1387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1391)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1454)..(1454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1464)..(1464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1479)..(1479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1485)..(1486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1498)..(1498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1516)..(1516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1548)..(1548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1552)..(1552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1567)..(1567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1571)..(1571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1584)..(1584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1589)..(1590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1597)..(1597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1635)..(1635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1649)..(1649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1662)..(1662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1677)..(1677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1682)..(1682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1702)..(1702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1731)..(1731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1743)..(1743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1748)..(1748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1750)..(1750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1763)..(1763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1792)..(1792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1803)..(1803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1811)..(1811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1860)..(1860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1862)..(1862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1875)..(1875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1880)..(1880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1885)..(1886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1888)..(1888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1896)..(1896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1902)..(1902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1906)..(1906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1947)..(1947)
<223> Selenocysteine

<400> 2754
Met Met Ala Xaa Arg Arg Xaa Gly Leu Ser Glu Gly Asp Gly Asp Lys 
1               5                   10                  15      


Leu Lys Ala Cys Glu Val Ser Lys Asn Lys Asp Gly Lys Glu Gln Ser 
            20                  25                  30          


Glu Xaa Val Ser Leu Ser Glu Asp Glu Xaa Phe Ser Trp Pro Gly Pro 
        35                  40                  45              


Lys Xaa Val Xaa Leu Lys Arg Xaa Ser Gln Gly Phe Gly Phe Xaa Leu 
    50                  55                  60                  


Arg His Phe Ile Val Tyr Pro Pro Glu Ser Ala Ile Gln Phe Ser Tyr 
65                  70                  75                  80  


Lys Asp Glu Glu Asn Gly Asn Arg Gly Gly Lys Gln Arg Asn Arg Leu 
                85                  90                  95      


Glu Pro Met Asp Xaa Ile Phe Val Lys Gln Val Lys Glu Gly Gly Pro 
            100                 105                 110         


Ala Phe Glu Ala Gly Leu Cys Xaa Gly Asp Arg Ile Ile Lys Val Asn 
        115                 120                 125             


Gly Glu Ser Val Ile Gly Lys Xaa Tyr Ser Gln Val Ile Ala Leu Ile 
    130                 135                 140                 


Gln Asn Ser Asp Xaa Xaa Leu Glu Leu Ser Val Met Pro Lys Asp Glu 
145                 150                 155                 160 


Asp Ile Leu Gln Val Leu Gln Phe Xaa Lys Asp Val Xaa Ala Leu Ala 
                165                 170                 175     


Tyr Ser Gln Asp Ala Tyr Leu Lys Gly Asn Glu Ala Tyr Ser Gly Asn 
            180                 185                 190         


Ala Arg Asn Ile Pro Glu Pro Pro Pro Ile Cys Tyr Pro Trp Leu Pro 
        195                 200                 205             


Ser Ala Pro Ser Ala Met Ala Gln Pro Val Glu Ile Ser Pro Pro Asp 
    210                 215                 220                 


Ser Ser Leu Ser Lys Gln Gln Xaa Ser Xaa Pro Val Leu Xaa Gln Pro 
225                 230                 235                 240 


Gly Arg Ala Tyr Arg Met Glu Ile Gln Val Pro Pro Ser Pro Xaa Asp 
                245                 250                 255     


Val Ala Lys Ser Asn Xaa Ala Val Cys Val Cys Asn Glu Ser Val Arg 
            260                 265                 270         


Xaa Val Ile Val Pro Ser Glu Lys Val Val Asp Leu Leu Ser Asn Arg 
        275                 280                 285             


Asn Asn His Xaa Gly Pro Ser His Arg Xaa Glu Glu Val Arg Tyr Gly 
    290                 295                 300                 


Val Ser Glu Gln Xaa Ser Leu Lys Xaa Val Ser Arg Xaa Xaa Ser Pro 
305                 310                 315                 320 


Pro Leu Ser Ile Pro Xaa Xaa His Leu Ile His Gln Pro Ala Gly Ser 
                325                 330                 335     


Arg Ser Leu Glu Pro Ser Gly Ile Leu Leu Lys Ser Gly Asn Tyr Ser 
            340                 345                 350         


Gly His Ser Asp Gly Ile Ser Ser Ser Arg Ser Gln Ala Val Glu Ala 
        355                 360                 365             


Pro Ser Val Ser Val Asn His Tyr Ser Pro Asn Ser His Gln His Ile 
    370                 375                 380                 


Asp Trp Lys Asn Tyr Lys Xaa Tyr Lys Glu Tyr Ile Asp Asn Arg Arg 
385                 390                 395                 400 


Leu His Ile Gly Cys Arg Xaa Ile Gln Glu Arg Leu Asp Ser Leu Arg 
                405                 410                 415     


Ala Ala Ser Gln Ser Xaa Xaa Asp Tyr Asn Gln Val Val Pro Asn Arg 
            420                 425                 430         


Xaa Xaa Leu Gln Gly Arg Arg Arg Ser Xaa Ser His Asp Arg Val Pro 
        435                 440                 445             


Gln Ser Val Gln Ile Arg Gln Arg Ser Val Ser Gln Glu Arg Leu Glu 
    450                 455                 460                 


Asp Ser Val Leu Met Lys Tyr Cys Pro Arg Ser Ala Ser Gln Gly Ala 
465                 470                 475                 480 


Leu Xaa Ser Pro Ser Val Ser Phe Ser Asn His Arg Xaa Arg Ser Trp 
                485                 490                 495     


Asp Tyr Ile Glu Gly Gln Asp Glu Xaa Leu Glu Asn Val Asn Ser Gly 
            500                 505                 510         


Xaa Pro Ile Pro Asp Ser Asn Gly Glu Lys Lys Gln Xaa Tyr Lys Trp 
        515                 520                 525             


Ser Gly Phe Xaa Glu Gln Asp Asp Arg Arg Gly Ile Cys Glu Arg Pro 
    530                 535                 540                 


Arg Gln Gln Glu Ile His Lys Ser Phe Arg Gly Ser Asn Phe Xaa Val 
545                 550                 555                 560 


Ala Pro Ser Val Val Asn Ser Asp Asn Arg Arg Met Ser Gly Arg Gly 
                565                 570                 575     


Val Gly Ser Val Ser Gln Phe Lys Lys Ile Pro Pro Asp Leu Lys Xaa 
            580                 585                 590         


Leu Gln Ser Asn Arg Asn Phe Gln Xaa Xaa Cys Gly Met Ser Leu Pro 
        595                 600                 605             


Arg Gly Ile Ser Gln Asp Arg Ser Pro Leu Val Lys Val Arg Ser Asn 
    610                 615                 620                 


Ser Leu Lys Ala Pro Ser Xaa His Val Xaa Lys Pro Ser Phe Ser Gln 
625                 630                 635                 640 


Lys Ser Phe Val Ser Ile Lys Asp Gln Arg Pro Val Asn His Leu His 
                645                 650                 655     


Gln Asn Ser Leu Leu Asn Gln Gln Xaa Trp Val Arg Xaa Asp Ser Ala 
            660                 665                 670         


Pro Asp Gln Gln Val Glu Xaa Gly Lys Ser Pro Ser Leu Ser Gly Ala 
        675                 680                 685             


Ser Ala Lys Pro Ala Pro Gln Ser Ser Glu Asn Ala Gly Xaa Ser Asp 
    690                 695                 700                 


Leu Glu Leu Pro Val Ser Gln Arg Asn Gln Asp Leu Ser Leu Gln Glu 
705                 710                 715                 720 


Ala Glu Xaa Glu Gln Ser Asp Xaa Leu Asp Asn Lys Glu Ala Val Ile 
                725                 730                 735     


Leu Arg Glu Lys Pro Pro Ser Gly Arg Gln Xaa Pro Gln Pro Leu Arg 
            740                 745                 750         


His Gln Ser Tyr Ile Leu Ala Val Asn Asp Gln Glu Xaa Gly Ser Asp 
        755                 760                 765             


Xaa Xaa Cys Trp Leu Pro Asn Asp Ala Arg Arg Glu Val His Ile Lys 
    770                 775                 780                 


Arg Met Glu Glu Arg Lys Ala Ser Ser Xaa Ser Pro Pro Gly Asp Ser 
785                 790                 795                 800 


Leu Ala Ser Ile Pro Phe Ile Asp Glu Pro Xaa Ser Pro Ser Ile Asp 
                805                 810                 815     


His Asp Ile Ala His Ile Pro Ala Ser Ala Val Ile Ser Ala Ser Xaa 
            820                 825                 830         


Ser Gln Val Pro Ser Ile Ala Xaa Val Pro Pro Cys Leu Xaa Xaa Ser 
        835                 840                 845             


Ala Pro Leu Ile Arg Arg Gln Leu Ser His Asp His Glu Ser Val Gly 
    850                 855                 860                 


Pro Pro Ser Leu Asp Ala Gln Pro Asn Ser Lys Xaa Glu Arg Ser Lys 
865                 870                 875                 880 


Ser Tyr Asp Glu Gly Leu Asp Asp Tyr Arg Glu Asp Ala Lys Leu Ser 
                885                 890                 895     


Phe Lys His Val Ser Ser Leu Lys Gly Ile Lys Ile Ala Asp Ser Gln 
            900                 905                 910         


Lys Ser Ser Glu Asp Ser Gly Ser Arg Lys Asp Ser Ser Ser Glu Val 
        915                 920                 925             


Phe Ser Asp Ala Ala Lys Glu Gly Trp Leu His Phe Arg Pro Leu Val 
    930                 935                 940                 


Xaa Asp Lys Gly Lys Arg Val Gly Gly Ser Ile Arg Pro Trp Lys Gln 
945                 950                 955                 960 


Met Tyr Val Val Leu Arg Gly His Ser Leu Tyr Leu Tyr Lys Asp Lys 
                965                 970                 975     


Arg Glu Gln Xaa Xaa Pro Ser Glu Glu Glu Gln Pro Ile Ser Val Asn 
            980                 985                 990         


Ala Cys Leu Ile Asp Ile Ser Tyr  Ser Glu Xaa Lys Arg  Lys Asn Val 
        995                 1000                 1005             


Phe Arg  Leu Xaa Xaa Ser Asp  Cys Glu Cys Leu Phe  Gln Ala Glu 
    1010                 1015                 1020             


Asp Arg  Asp Asp Met Leu Ala  Trp Ile Lys Xaa Ile  Gln Glu Ser 
    1025                 1030                 1035             


Ser Asn  Leu Asn Glu Glu Asp  Xaa Gly Val Xaa Asn  Arg Asp Leu 
    1040                 1045                 1050             


Ile Ser  Arg Arg Ile Lys Glu  Tyr Asn Asn Leu Met  Ser Lys Ala 
    1055                 1060                 1065             


Glu Gln  Leu Pro Lys Xaa Pro  Arg Gln Ser Leu Ser  Ile Arg Gln 
    1070                 1075                 1080             


Xaa Leu  Leu Gly Ala Lys Ser  Glu Pro Lys Xaa Gln  Ser Pro His 
    1085                 1090                 1095             


Ser Pro  Lys Glu Glu Ser Glu  Arg Lys Leu Leu Ser  Lys Asp Asp 
    1100                 1105                 1110             


Xaa Ser  Pro Pro Lys Asp Lys  Gly Xaa Trp Arg Lys  Gly Ile Pro 
    1115                 1120                 1125             


Ser Ile  Met Arg Lys Xaa Phe  Glu Lys Lys Pro Xaa  Ala Xaa Gly 
    1130                 1135                 1140             


Xaa Phe  Gly Val Arg Leu Asp  Asp Cys Pro Pro Ala  His Xaa Asn 
    1145                 1150                 1155             


Arg Tyr  Ile Pro Leu Ile Val  Asp Ile Cys Cys Lys  Leu Val Glu 
    1160                 1165                 1170             


Glu Arg  Gly Leu Glu Tyr Xaa  Gly Ile Tyr Arg Val  Pro Gly Asn 
    1175                 1180                 1185             


Asn Ala  Ala Ile Ser Ser Met  Gln Glu Glu Leu Asn  Lys Gly Met 
    1190                 1195                 1200             


Ala Asp  Ile Asp Ile Gln Asp  Asp Lys Trp Arg Asp  Leu Asn Val 
    1205                 1210                 1215             


Ile Ser  Ser Leu Leu Lys Ser  Phe Phe Arg Lys Leu  Pro Glu Pro 
    1220                 1225                 1230             


Leu Phe  Xaa Asn Asp Lys Tyr  Ala Asp Phe Ile Glu  Ala Asn Arg 
    1235                 1240                 1245             


Lys Glu  Asp Pro Leu Asp Arg  Leu Lys Xaa Leu Lys  Arg Leu Ile 
    1250                 1255                 1260             


His Asp  Leu Pro Glu His His  Tyr Glu Xaa Leu Lys  Phe Leu Ser 
    1265                 1270                 1275             


Ala His  Leu Lys Xaa Val Ala  Glu Asn Ser Glu Lys  Asn Lys Met 
    1280                 1285                 1290             


Glu Pro  Arg Asn Leu Ala Ile  Val Phe Gly Pro Xaa  Leu Val Arg 
    1295                 1300                 1305             


Xaa Ser  Glu Asp Asn Met Xaa  His Met Val Xaa His  Met Pro Asp 
    1310                 1315                 1320             


Gln Tyr  Lys Ile Val Glu Xaa  Leu Ile Gln His His  Asp Trp Phe 
    1325                 1330                 1335             


Phe Xaa  Glu Glu Gly Ala Glu  Glu Pro Leu Xaa Xaa  Val Gln Glu 
    1340                 1345                 1350             


Glu Ser  Xaa Val Asp Ser Gln  Pro Val Pro Asn Ile  Asp His Leu 
    1355                 1360                 1365             


Leu Xaa  Asn Ile Gly Arg Xaa  Gly Val Ser Pro Gly  Asp Val Ser 
    1370                 1375                 1380             


Asp Ser  Ala Xaa Ser Asp Ser  Xaa Lys Ser Lys Gly  Ser Trp Gly 
    1385                 1390                 1395             


Ser Gly  Lys Asp Gln Tyr Ser  Arg Glu Leu Leu Val  Ser Ser Ile 
    1400                 1405                 1410             


Phe Ala  Ala Ala Ser Arg Lys  Arg Lys Lys Pro Lys  Glu Lys Ala 
    1415                 1420                 1425             


Gln Pro  Ser Ser Ser Glu Asp  Glu Leu Asp Asn Val  Phe Phe Lys 
    1430                 1435                 1440             


Lys Glu  Asn Val Glu Gln Cys  His Asn Asp Xaa Lys  Glu Glu Ser 
    1445                 1450                 1455             


Lys Lys  Glu Ser Glu Xaa Leu  Gly Arg Lys Gln Lys  Ile Ile Ile 
    1460                 1465                 1470             


Ala Lys  Glu Asn Ser Xaa Arg  Lys Asp Pro Ser Xaa  Xaa Lys Asp 
    1475                 1480                 1485             


Glu Lys  Ile Ser Leu Gly Lys  Glu Ser Xaa Pro Ser  Glu Glu Pro 
    1490                 1495                 1500             


Ser Pro  Pro His Asn Ser Lys  His Asn Lys Ser Pro  Xaa Leu Ser 
    1505                 1510                 1515             


Cys Arg  Phe Ala Ile Leu Lys  Glu Ser Pro Arg Ser  Leu Leu Ala 
    1520                 1525                 1530             


Gln Lys  Ser Ser His Leu Glu  Glu Xaa Gly Ser Asp  Ser Gly Xaa 
    1535                 1540                 1545             


Leu Leu  Ser Xaa Ser Ser Gln  Ala Ser Leu Ala Arg  Phe Ser Met 
    1550                 1555                 1560             


Lys Lys  Ser Xaa Ser Pro Glu  Xaa Lys His Ser Glu  Phe Leu Ala 
    1565                 1570                 1575             


Asn Val  Ser Xaa Ile Xaa Ser  Asp Tyr Ser Xaa Xaa  Ser Ser Ala 
    1580                 1585                 1590             


Xaa Tyr  Leu Xaa Ser Leu Asp  Ser Ser Arg Leu Ser  Pro Glu Val 
    1595                 1600                 1605             


Gln Ser  Val Ala Glu Ser Lys  Gly Asp Glu Ala Asp  Asp Glu Arg 
    1610                 1615                 1620             


Ser Glu  Leu Ile Ser Glu Gly  Arg Pro Val Glu Xaa  Asp Ser Glu 
    1625                 1630                 1635             


Ser Glu  Phe Pro Val Phe Pro  Xaa Ala Leu Xaa Ser  Glu Arg Leu 
    1640                 1645                 1650             


Phe Arg  Gly Lys Leu Gln Glu  Val Xaa Lys Ser Ser  Arg Arg Asn 
    1655                 1660                 1665             


Ser Glu  Gly Ser Glu Leu Ser  Cys Xaa Glu Gly Ser  Leu Xaa Ser 
    1670                 1675                 1680             


Ser Leu  Asp Ser Arg Arg Gln  Leu Phe Ser Ser His  Lys Leu Ile 
    1685                 1690                 1695             


Glu Cys  Asp Xaa Leu Ser Arg  Lys Lys Ser Ala Arg  Phe Lys Ser 
    1700                 1705                 1710             


Asp Ser  Gly Ser Leu Gly Asp  Ala Lys Asn Glu Lys  Glu Ala Pro 
    1715                 1720                 1725             


Ser Leu  Xaa Lys Val Phe Asp  Val Met Lys Lys Gly  Lys Ser Xaa 
    1730                 1735                 1740             


Gly Ser  Leu Leu Xaa Pro Xaa  Arg Gly Glu Ser Glu  Lys Gln Glu 
    1745                 1750                 1755             


Pro Xaa  Trp Lys Xaa Lys Ile  Ala Asp Arg Leu Lys  Leu Arg Pro 
    1760                 1765                 1770             


Arg Ala  Pro Ala Asp Asp Met  Phe Gly Val Gly Asn  His Lys Val 
    1775                 1780                 1785             


Asn Ala  Glu Xaa Ala Lys Arg  Lys Ser Ile Arg Arg  Arg His Xaa 
    1790                 1795                 1800             


Leu Gly  Gly His Arg Asp Ala  Xaa Glu Ile Ser Val  Leu Asn Phe 
    1805                 1810                 1815             


Trp Lys  Val His Glu Gln Ser  Gly Glu Arg Glu Ser  Glu Leu Ser 
    1820                 1825                 1830             


Ala Val  Asn Arg Leu Lys Pro  Lys Cys Ser Ala Gln  Asp Leu Ser 
    1835                 1840                 1845             


Ile Ser  Asp Trp Leu Ala Arg  Glu Arg Leu Arg Xaa  Ser Xaa Ser 
    1850                 1855                 1860             


Asp Leu  Ser Arg Gly Glu Ile  Gly Asp Pro Gln Xaa  Glu Asn Pro 
    1865                 1870                 1875             


Ser Xaa  Arg Glu Ile Ala Xaa  Xaa Asp Xaa Pro Leu  Ser Leu His 
    1880                 1885                 1890             


Cys Asn  Xaa Gly Ser Ser Ser  Ser Xaa Leu Ala Ser  Xaa Asn Arg 
    1895                 1900                 1905             


Pro Leu  Leu Ser Ile Pro Pro  Gln Ser Pro Asp Gln  Ile Asn Gly 
    1910                 1915                 1920             


Glu Ser  Phe Gln Asn Val Ser  Lys Asn Ala Ser Ser  Ala Ala Asn 
    1925                 1930                 1935             


Ala Gln  Pro His Lys Leu Ser  Glu Xaa Pro Gly Ser  Lys Ala Glu 
    1940                 1945                 1950             


Phe His  Pro Cys Leu 
    1955             


<210> 2755
<211> 197
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<400> 2755
Xaa Asn Asn Ala Ala Ile Ser Ser Met Gln Glu Glu Leu Asn Lys Gly 
1               5                   10                  15      


Met Ala Asp Ile Asp Ile Gln Asp Asp Lys Trp Arg Asp Leu Asn Val 
            20                  25                  30          


Ile Ser Ser Leu Leu Lys Ser Phe Phe Arg Lys Leu Pro Glu Pro Leu 
        35                  40                  45              


Phe Xaa Asn Asp Lys Tyr Ala Asp Phe Ile Glu Ala Asn Arg Lys Glu 
    50                  55                  60                  


Asp Pro Leu Asp Arg Leu Lys Xaa Leu Lys Arg Leu Ile His Asp Leu 
65                  70                  75                  80  


Pro Glu His His Tyr Glu Xaa Leu Lys Phe Leu Ser Ala His Leu Lys 
                85                  90                  95      


Xaa Val Ala Glu Asn Ser Glu Lys Asn Lys Met Glu Pro Arg Asn Leu 
            100                 105                 110         


Ala Ile Val Phe Gly Pro Xaa Leu Val Arg Xaa Ser Glu Asp Asn Met 
        115                 120                 125             


Xaa His Met Val Xaa His Met Pro Asp Gln Tyr Lys Ile Val Glu Xaa 
    130                 135                 140                 


Leu Ile Gln His His Asp Trp Phe Phe Xaa Glu Glu Gly Ala Glu Glu 
145                 150                 155                 160 


Pro Leu Ile Gln Leu Leu Val Xaa Gln Gln Asn Leu Arg Val Leu Gly 
                165                 170                 175     


Asp Leu Glu Arg Ile Ser Ile Ala Gly Asn Cys Leu Cys Pro Pro Ser 
            180                 185                 190         


Leu Gln Leu Leu Val 
        195         


<210> 2756
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 2756
Tyr Ile Pro Leu Ile Val Asp Ile Cys Cys Lys Leu Val Glu Glu Arg 
1               5                   10                  15      


Gly Leu Glu Tyr Xaa Gly Ile Tyr Arg Val Pro Gly Asn Asn Ala Ala 
            20                  25                  30          


Ile Ser Ser Met Gln Glu Glu Leu Asn Lys Gly Met Ala Asp Ile Asp 
        35                  40                  45              


Ile Gln Asp Asp Lys Trp Arg Asp Leu Asn Val Ile Ser Ser Leu Leu 
    50                  55                  60                  


Lys Ser Phe Phe Arg Lys Leu Pro Glu Pro Leu Phe Xaa Asn Asp Lys 
65                  70                  75                  80  


Tyr Ala Asp Phe Ile Glu Ala Asn Arg Lys Glu Asp Pro Leu Asp Arg 
                85                  90                  95      


Leu Lys Xaa Leu Lys Arg Leu Phe Leu Ser Ala His Leu Lys Xaa Val 
            100                 105                 110         


Ala 
    


<210> 2757
<211> 589
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<400> 2757
Met Ala Ser Ser Gln Arg Asp Met Glu Asp Trp Val Gln Ala Ile Arg 
1               5                   10                  15      


Arg Val Ile Trp Ala Pro Leu Gly Gly Gly Xaa Ala Arg Arg Ser His 
            20                  25                  30          


Ala His Pro Leu Glu Pro Leu Pro Pro Gly Ile Phe Gly Gln Arg Leu 
        35                  40                  45              


Glu Glu Xaa Val His His Glu Arg Lys Tyr Gly Pro Arg Leu Ala Pro 
    50                  55                  60                  


Leu Leu Val Glu Gln Cys Val Asp Phe Ile Arg Glu Arg Gly Leu Xaa 
65                  70                  75                  80  


Glu Glu Gly Leu Phe Arg Met Pro Gly Gln Ala Asn Leu Val Arg Asp 
                85                  90                  95      


Leu Gln Asp Ser Phe Asp Cys Gly Glu Lys Pro Leu Phe Asp Ser Xaa 
            100                 105                 110         


Xaa Asp Val His Xaa Val Ala Ser Leu Leu Lys Leu Tyr Leu Arg Glu 
        115                 120                 125             


Leu Pro Glu Pro Val Val Pro Phe Ala Arg Tyr Glu Asp Phe Leu Ser 
    130                 135                 140                 


Cys Ala Gln Leu Leu Xaa Lys Asp Glu Gly Glu Gly Xaa Leu Glu Leu 
145                 150                 155                 160 


Ala Lys Gln Val Ser Asn Leu Pro Gln Ala Asn Tyr Asn Leu Leu Arg 
                165                 170                 175     


Tyr Ile Cys Lys Phe Leu Asp Glu Val Gln Ala Tyr Ser Asn Val Asn 
            180                 185                 190         


Lys Met Ser Val Gln Asn Leu Ala Xaa Val Phe Gly Pro Asn Ile Leu 
        195                 200                 205             


Arg Pro Gln Val Glu Asp Pro Val Xaa Ile Met Glu Gly Xaa Ser Leu 
    210                 215                 220                 


Val Gln His Leu Met Xaa Val Leu Ile Arg Lys His Ser Gln Leu Phe 
225                 230                 235                 240 


Xaa Ala Pro Val Pro Glu Gly Pro Xaa Ser Pro Arg Gly Gly Leu Gln 
                245                 250                 255     


Cys Ala Val Gly Trp Gly Ser Glu Glu Val Xaa Arg Asp Ser Gln Gly 
            260                 265                 270         


Glu Pro Gly Gly Pro Gly Leu Pro Ala His Arg Xaa Ser Ser Leu Asp 
        275                 280                 285             


Gly Ala Ala Val Ala Val Leu Ser Arg Xaa Ala Pro Xaa Gly Pro Gly 
    290                 295                 300                 


Ser Arg Cys Ser Pro Gly Lys Lys Val Gln Xaa Leu Pro Ser Trp Lys 
305                 310                 315                 320 


Ser Ser Phe Arg Gln Pro Arg Ser Leu Ser Gly Ser Pro Lys Gly Gly 
                325                 330                 335     


Gly Ser Ser Leu Glu Val Pro Ile Ile Ser Ser Gly Gly Asn Trp Leu 
            340                 345                 350         


Met Asn Gly Leu Ser Ser Leu Arg Gly His Arg Arg Ala Ser Ser Gly 
        355                 360                 365             


Asp Arg Leu Lys Asp Ser Gly Ser Val Gln Arg Leu Ser Xaa Tyr Asp 
    370                 375                 380                 


Asn Val Pro Ala Pro Gly Leu Val Pro Gly Ile Pro Ser Val Ala Ser 
385                 390                 395                 400 


Met Ala Trp Ser Gly Ala Ser Ser Ser Glu Ser Ser Val Gly Gly Ser 
                405                 410                 415     


Leu Ser Ser Cys Xaa Ala Cys Arg Ala Ser Asp Ser Ser Ala Arg Ser 
            420                 425                 430         


Ser Leu His Xaa Asp Trp Ala Leu Glu Pro Ser Pro Leu Pro Ser Ser 
        435                 440                 445             


Ser Glu Asp Pro Lys Ser Leu Asp Leu Asp His Ser Met Asp Glu Ala 
    450                 455                 460                 


Gly Ala Gly Ala Ser Asn Ser Glu Pro Ser Glu Pro Asp Ser Pro Xaa 
465                 470                 475                 480 


Arg Glu His Ala Arg Arg Ser Glu Ala Leu Gln Gly Leu Val Xaa Glu 
                485                 490                 495     


Leu Arg Ala Glu Leu Cys Arg Gln Arg Xaa Glu Tyr Glu Arg Ser Val 
            500                 505                 510         


Lys Arg Ile Glu Glu Gly Ser Ala Asp Leu Arg Lys Arg Met Ser Arg 
        515                 520                 525             


Leu Glu Glu Glu Leu Asp Gln Glu Lys Lys Lys Tyr Ile Met Leu Glu 
    530                 535                 540                 


Ile Lys Leu Arg Asn Ser Glu Arg Ala Arg Glu Asp Ala Glu Arg Arg 
545                 550                 555                 560 


Asn Gln Leu Leu Gln Arg Glu Met Glu Glu Phe Phe Ser Xaa Leu Gly 
                565                 570                 575     


Ser Leu Xaa Val Gly Ala Lys Gly Ala Arg Ala Pro Lys 
            580                 585                 


<210> 2758
<211> 531
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<400> 2758
Met Cys Val Pro Pro His Arg Lys Asp Gly Ser Ile Pro Cys Pro Arg 
1               5                   10                  15      


Ala Leu Cys Ser Gln Ser Val Asp Ile Gln Ala Trp Gln Leu Ser Ala 
            20                  25                  30          


Ala Gln Arg Gly Asp Val Gly Gln Pro Arg Glu Phe Trp His Leu Arg 
        35                  40                  45              


Ser Gln Val Pro Val Pro Xaa Cys His Leu Leu Xaa Val Gln Pro Trp 
    50                  55                  60                  


Cys Leu Leu Pro His Pro Xaa Pro Ala Gly Gly Arg Glu Arg Arg His 
65                  70                  75                  80  


Ser Ala Ser Ser Leu Leu Ala Ala Leu Cys Leu Arg Lys Ala Val Leu 
                85                  90                  95      


Arg Pro His Pro Ala Val Leu Pro Gly Val Gly Gly Cys Val Val Leu 
            100                 105                 110         


Ser Ser Gly Arg Met Lys Ala Pro Leu Arg Gly Gly Leu Ala Leu Gly 
        115                 120                 125             


Xaa Gly Pro Ala Pro Xaa Lys Leu Gln Leu Leu His Asp Trp Gln Ser 
    130                 135                 140                 


Glu Pro Gly Pro Ser Gly Trp Gln Gln Gly Pro Ser Pro Pro Leu Phe 
145                 150                 155                 160 


Pro Ala Gly Xaa Ser Leu Val Gln His Leu Met Xaa Val Leu Ile Arg 
                165                 170                 175     


Lys His Ser Gln Leu Phe Xaa Ala Pro Val Pro Glu Gly Pro Xaa Ser 
            180                 185                 190         


Pro Arg Gly Gly Leu Gln Cys Ala Val Gly Trp Gly Ser Glu Glu Val 
        195                 200                 205             


Xaa Arg Asp Ser Gln Gly Glu Pro Gly Gly Pro Gly Leu Pro Ala His 
    210                 215                 220                 


Arg Xaa Ser Ser Leu Asp Gly Ala Ala Val Ala Val Leu Ser Arg Xaa 
225                 230                 235                 240 


Ala Pro Xaa Gly Pro Gly Ser Arg Cys Ser Pro Gly Lys Lys Val Gln 
                245                 250                 255     


Xaa Leu Pro Ser Trp Lys Ser Ser Phe Arg Gln Pro Arg Ser Leu Ser 
            260                 265                 270         


Gly Ser Pro Lys Gly Gly Gly Ser Ser Leu Glu Val Pro Ile Ile Ser 
        275                 280                 285             


Ser Gly Gly Asn Trp Leu Met Asn Gly Leu Ser Ser Leu Arg Gly His 
    290                 295                 300                 


Arg Arg Ala Ser Ser Gly Asp Arg Leu Lys Asp Ser Gly Ser Val Gln 
305                 310                 315                 320 


Arg Leu Ser Xaa Tyr Asp Asn Val Pro Ala Pro Gly Leu Val Pro Gly 
                325                 330                 335     


Ile Pro Ser Val Ala Ser Met Ala Trp Ser Gly Ala Ser Ser Ser Glu 
            340                 345                 350         


Ser Ser Val Gly Gly Ser Leu Ser Ser Cys Xaa Ala Cys Arg Ala Ser 
        355                 360                 365             


Asp Ser Ser Ala Arg Ser Ser Leu His Xaa Asp Trp Ala Leu Glu Pro 
    370                 375                 380                 


Ser Pro Leu Pro Ser Ser Ser Glu Asp Pro Lys Ser Leu Asp Leu Asp 
385                 390                 395                 400 


His Ser Met Asp Glu Ala Gly Ala Gly Ala Ser Asn Ser Glu Pro Ser 
                405                 410                 415     


Glu Pro Asp Ser Pro Xaa Arg Glu His Ala Arg Arg Ser Glu Ala Leu 
            420                 425                 430         


Gln Gly Leu Val Xaa Glu Leu Arg Ala Glu Leu Cys Arg Gln Arg Xaa 
        435                 440                 445             


Glu Tyr Glu Arg Ser Val Lys Arg Ile Glu Glu Gly Ser Ala Asp Leu 
    450                 455                 460                 


Arg Lys Arg Met Ser Arg Leu Glu Glu Glu Leu Asp Gln Glu Lys Lys 
465                 470                 475                 480 


Lys Tyr Ile Met Leu Glu Ile Lys Leu Arg Asn Ser Glu Arg Ala Arg 
                485                 490                 495     


Glu Asp Ala Glu Arg Arg Asn Gln Leu Leu Gln Arg Glu Met Glu Glu 
            500                 505                 510         


Phe Phe Ser Xaa Leu Gly Ser Leu Xaa Val Gly Ala Lys Gly Ala Arg 
        515                 520                 525             


Ala Pro Lys 
    530     


<210> 2759
<211> 539
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<400> 2759
Met Gly Leu Cys Cys Cys Lys Asp Trp Arg Gly His Leu Arg Ala Pro 
1               5                   10                  15      


Lys Gly Gly Ala Gly Glu Arg Glu Lys Val Pro Ala Asn Pro Glu Ala 
            20                  25                  30          


Leu Leu Leu Met Ala Ser Ser Gln Arg Asp Met Glu Asp Trp Val Gln 
        35                  40                  45              


Ala Ile Arg Arg Val Ile Trp Ala Pro Leu Gly Gly Gly Ile Phe Gly 
    50                  55                  60                  


Gln Arg Leu Glu Glu Xaa Val His His Glu Arg Lys Tyr Gly Pro Arg 
65                  70                  75                  80  


Leu Ala Pro Leu Leu Val Glu Gln Cys Val Asp Phe Ile Arg Glu Arg 
                85                  90                  95      


Gly Leu Xaa Glu Glu Gly Leu Phe Arg Met Pro Gly Gln Ala Asn Leu 
            100                 105                 110         


Val Arg Asp Leu Gln Asp Ser Phe Asp Cys Gly Glu Lys Pro Leu Phe 
        115                 120                 125             


Asp Arg Phe Leu Asp Glu Val Gln Ala Tyr Ser Asn Val Asn Lys Met 
    130                 135                 140                 


Ser Val Gln Asn Leu Ala Xaa Val Phe Gly Pro Asn Ile Leu Arg Pro 
145                 150                 155                 160 


Gln Val Glu Asp Pro Val Xaa Ile Met Glu Gly Xaa Ser Leu Val Gln 
                165                 170                 175     


His Leu Met Xaa Val Leu Ile Arg Lys His Ser Gln Leu Phe Xaa Ala 
            180                 185                 190         


Pro Val Pro Glu Gly Pro Xaa Ser Pro Arg Gly Gly Leu Gln Cys Ala 
        195                 200                 205             


Val Gly Trp Gly Ser Glu Glu Val Xaa Arg Asp Ser Gln Gly Glu Pro 
    210                 215                 220                 


Gly Gly Pro Gly Leu Pro Ala His Arg Xaa Ser Ser Leu Asp Gly Ala 
225                 230                 235                 240 


Ala Val Ala Val Leu Ser Arg Xaa Ala Pro Xaa Gly Pro Gly Ser Arg 
                245                 250                 255     


Cys Ser Pro Gly Lys Lys Val Gln Xaa Leu Pro Ser Trp Lys Ser Ser 
            260                 265                 270         


Phe Arg Gln Pro Arg Ser Leu Ser Gly Ser Pro Lys Gly Gly Gly Ser 
        275                 280                 285             


Ser Leu Glu Val Pro Ile Ile Ser Ser Gly Gly Asn Trp Leu Met Asn 
    290                 295                 300                 


Gly Leu Ser Ser Leu Arg Gly His Arg Arg Ala Ser Ser Gly Asp Arg 
305                 310                 315                 320 


Leu Lys Asp Ser Gly Ser Val Gln Arg Leu Ser Xaa Tyr Asp Asn Val 
                325                 330                 335     


Pro Ala Pro Gly Leu Val Pro Gly Ile Pro Ser Val Ala Ser Met Ala 
            340                 345                 350         


Trp Ser Gly Ala Ser Ser Ser Glu Ser Ser Val Gly Gly Ser Leu Ser 
        355                 360                 365             


Ser Cys Xaa Ala Cys Arg Ala Ser Asp Ser Ser Ala Arg Ser Ser Leu 
    370                 375                 380                 


His Xaa Asp Trp Ala Leu Glu Pro Ser Pro Leu Pro Ser Ser Ser Glu 
385                 390                 395                 400 


Asp Pro Lys Ser Leu Asp Leu Asp His Ser Met Asp Glu Ala Gly Ala 
                405                 410                 415     


Gly Ala Ser Asn Ser Glu Pro Ser Glu Pro Asp Ser Pro Xaa Arg Glu 
            420                 425                 430         


His Ala Arg Arg Ser Glu Ala Leu Gln Gly Leu Val Xaa Glu Leu Arg 
        435                 440                 445             


Ala Glu Leu Cys Arg Gln Arg Xaa Glu Tyr Glu Arg Ser Val Lys Arg 
    450                 455                 460                 


Ile Glu Glu Gly Ser Ala Asp Leu Arg Lys Arg Met Ser Arg Leu Glu 
465                 470                 475                 480 


Glu Glu Leu Asp Gln Glu Lys Lys Lys Tyr Ile Met Leu Glu Ile Lys 
                485                 490                 495     


Leu Arg Asn Ser Glu Arg Ala Arg Glu Asp Ala Glu Arg Arg Asn Gln 
            500                 505                 510         


Leu Leu Gln Arg Glu Met Glu Glu Phe Phe Ser Xaa Leu Gly Ser Leu 
        515                 520                 525             


Xaa Val Gly Ala Lys Gly Ala Arg Ala Pro Lys 
    530                 535                 


<210> 2760
<211> 261
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<400> 2760
Met Leu Pro Xaa Ala Ser Ser Lys Arg Arg Xaa Phe Ala Ala Arg Tyr 
1               5                   10                  15      


Phe Xaa Arg Ser Lys Ser Leu Val Met Gly Glu Gln Ser Arg Ser Pro 
            20                  25                  30          


Gly Arg Met Pro Cys Pro His Arg Leu Gly Pro Val Leu Lys Ala Gly 
        35                  40                  45              


Trp Leu Lys Lys Gln Arg Ser Ile Met Lys Asn Trp Gln Gln Arg Trp 
    50                  55                  60                  


Phe Val Leu Arg Gly Asp Gln Leu Phe Tyr Tyr Lys Asp Lys Asp Glu 
65                  70                  75                  80  


Ile Lys Pro Gln Gly Phe Ile Ser Leu Gln Gly Xaa Gln Val Xaa Glu 
                85                  90                  95      


Leu Pro Pro Gly Pro Glu Asp Pro Gly Lys His Leu Phe Glu Ile Ser 
            100                 105                 110         


Pro Gly Gly Ala Gly Glu Arg Glu Lys Val Pro Ala Asn Pro Glu Ala 
        115                 120                 125             


Leu Leu Leu Met Ala Ser Ser Gln Arg Asp Met Glu Asp Trp Val Gln 
    130                 135                 140                 


Ala Ile Arg Arg Val Ile Trp Ala Pro Leu Gly Gly Gly Ile Phe Gly 
145                 150                 155                 160 


Gln Arg Leu Glu Glu Xaa Val His His Glu Arg Lys Tyr Gly Pro Arg 
                165                 170                 175     


Leu Ala Pro Leu Leu Val Glu Gln Cys Val Asp Phe Ile Arg Glu Arg 
            180                 185                 190         


Gly Leu Xaa Glu Glu Gly Leu Phe Arg Met Pro Gly Gln Ala Asn Leu 
        195                 200                 205             


Val Arg Asp Leu Gln Asp Ser Phe Asp Cys Gly Glu Lys Pro Leu Phe 
    210                 215                 220                 


Asp Ser Xaa Xaa Asp Val His Xaa Val Ala Ser Leu Leu Lys Leu Tyr 
225                 230                 235                 240 


Leu Arg Glu Leu Pro Glu Pro Val Val Pro Phe Ala Arg Ala Leu Trp 
                245                 250                 255     


Ser Trp Leu Asn Lys 
            260     


<210> 2761
<211> 704
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<400> 2761
Met Leu Pro Xaa Ala Ser Ser Lys Arg Arg Xaa Phe Ala Ala Arg Tyr 
1               5                   10                  15      


Phe Xaa Arg Ser Lys Ser Leu Val Met Gly Glu Gln Ser Arg Ser Pro 
            20                  25                  30          


Gly Arg Met Pro Cys Pro His Arg Leu Gly Pro Val Leu Lys Ala Gly 
        35                  40                  45              


Trp Leu Lys Lys Gln Arg Ser Ile Met Lys Asn Trp Gln Gln Arg Trp 
    50                  55                  60                  


Phe Val Leu Arg Gly Asp Gln Leu Phe Tyr Tyr Lys Asp Lys Asp Glu 
65                  70                  75                  80  


Ile Lys Pro Gln Gly Phe Ile Ser Leu Gln Gly Xaa Gln Val Xaa Glu 
                85                  90                  95      


Leu Pro Pro Gly Pro Glu Asp Pro Gly Lys His Leu Phe Glu Ile Ser 
            100                 105                 110         


Pro Gly Gly Ala Gly Glu Arg Glu Lys Val Pro Ala Asn Pro Glu Ala 
        115                 120                 125             


Leu Leu Leu Met Ala Ser Ser Gln Arg Asp Met Glu Asp Trp Val Gln 
    130                 135                 140                 


Ala Ile Arg Arg Val Ile Trp Ala Pro Leu Gly Gly Gly Ile Phe Gly 
145                 150                 155                 160 


Gln Arg Leu Glu Glu Xaa Val His His Glu Arg Lys Tyr Gly Pro Arg 
                165                 170                 175     


Leu Ala Pro Leu Leu Val Glu Gln Cys Val Asp Phe Ile Arg Glu Arg 
            180                 185                 190         


Gly Leu Xaa Glu Glu Gly Leu Phe Arg Met Pro Gly Gln Ala Asn Leu 
        195                 200                 205             


Val Arg Asp Leu Gln Asp Ser Phe Asp Cys Gly Glu Lys Pro Leu Phe 
    210                 215                 220                 


Asp Ser Xaa Xaa Asp Val His Xaa Val Ala Ser Leu Leu Lys Leu Tyr 
225                 230                 235                 240 


Leu Arg Glu Leu Pro Glu Pro Val Val Pro Phe Ala Arg Tyr Glu Asp 
                245                 250                 255     


Phe Leu Ser Cys Ala Gln Leu Leu Xaa Lys Asp Glu Gly Glu Gly Xaa 
            260                 265                 270         


Leu Glu Leu Ala Lys Gln Val Ser Asn Leu Pro Gln Ala Asn Tyr Asn 
        275                 280                 285             


Leu Leu Arg Tyr Ile Cys Lys Phe Leu Asp Glu Val Gln Ala Tyr Ser 
    290                 295                 300                 


Asn Val Asn Lys Met Ser Val Gln Asn Leu Ala Xaa Val Phe Gly Pro 
305                 310                 315                 320 


Asn Ile Leu Arg Pro Gln Val Glu Asp Pro Val Xaa Ile Met Glu Gly 
                325                 330                 335     


Xaa Ser Leu Val Gln His Leu Met Xaa Val Leu Ile Arg Lys His Ser 
            340                 345                 350         


Gln Leu Phe Xaa Ala Pro Val Pro Glu Gly Pro Xaa Ser Pro Arg Gly 
        355                 360                 365             


Gly Leu Gln Cys Ala Val Gly Trp Gly Ser Glu Glu Val Xaa Arg Asp 
    370                 375                 380                 


Ser Gln Gly Glu Pro Gly Gly Pro Gly Leu Pro Ala His Arg Xaa Ser 
385                 390                 395                 400 


Ser Leu Asp Gly Ala Ala Val Ala Val Leu Ser Arg Xaa Ala Pro Xaa 
                405                 410                 415     


Gly Pro Gly Ser Arg Cys Ser Pro Gly Lys Lys Val Gln Xaa Leu Pro 
            420                 425                 430         


Ser Trp Lys Ser Ser Phe Arg Gln Pro Arg Ser Leu Ser Gly Ser Pro 
        435                 440                 445             


Lys Gly Gly Gly Ser Ser Leu Glu Val Pro Ile Ile Ser Ser Gly Gly 
    450                 455                 460                 


Asn Trp Leu Met Asn Gly Leu Ser Ser Leu Arg Gly His Arg Arg Ala 
465                 470                 475                 480 


Ser Ser Gly Asp Arg Leu Lys Asp Ser Gly Ser Val Gln Arg Leu Ser 
                485                 490                 495     


Xaa Tyr Asp Asn Val Pro Ala Pro Gly Leu Val Pro Gly Ile Pro Ser 
            500                 505                 510         


Val Ala Ser Met Ala Trp Ser Gly Ala Ser Ser Ser Glu Ser Ser Val 
        515                 520                 525             


Gly Gly Ser Leu Ser Ser Cys Xaa Ala Cys Arg Ala Ser Asp Ser Ser 
    530                 535                 540                 


Ala Arg Ser Ser Leu His Xaa Asp Trp Ala Leu Glu Pro Ser Pro Leu 
545                 550                 555                 560 


Pro Ser Ser Ser Glu Asp Pro Lys Ser Leu Asp Leu Asp His Ser Met 
                565                 570                 575     


Asp Glu Ala Gly Ala Gly Ala Ser Asn Ser Glu Pro Ser Glu Pro Asp 
            580                 585                 590         


Ser Pro Xaa Arg Glu His Ala Arg Arg Ser Glu Ala Leu Gln Gly Leu 
        595                 600                 605             


Val Xaa Glu Leu Arg Ala Glu Leu Cys Arg Gln Arg Xaa Glu Tyr Glu 
    610                 615                 620                 


Arg Ser Val Lys Arg Ile Glu Glu Gly Ser Ala Asp Leu Arg Lys Arg 
625                 630                 635                 640 


Met Ser Arg Leu Glu Glu Glu Leu Asp Gln Glu Lys Lys Lys Tyr Ile 
                645                 650                 655     


Met Leu Glu Ile Lys Leu Arg Asn Ser Glu Arg Ala Arg Glu Asp Ala 
            660                 665                 670         


Glu Arg Arg Asn Gln Leu Leu Gln Arg Glu Met Glu Glu Phe Phe Ser 
        675                 680                 685             


Xaa Leu Gly Ser Leu Xaa Val Gly Ala Lys Gly Ala Arg Ala Pro Lys 
    690                 695                 700                 


<210> 2762
<211> 698
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<400> 2762
Met Leu Ser Pro Lys Ile Arg Gln Ala Arg Arg Ala Arg Ser Lys Ser 
1               5                   10                  15      


Leu Val Met Gly Glu Gln Ser Arg Ser Pro Gly Arg Met Pro Cys Pro 
            20                  25                  30          


His Arg Leu Gly Pro Val Leu Lys Ala Gly Trp Leu Lys Lys Gln Arg 
        35                  40                  45              


Ser Ile Met Lys Asn Trp Gln Gln Arg Trp Phe Val Leu Arg Gly Asp 
    50                  55                  60                  


Gln Leu Phe Tyr Tyr Lys Asp Lys Asp Glu Ile Lys Pro Gln Gly Phe 
65                  70                  75                  80  


Ile Ser Leu Gln Gly Xaa Gln Val Xaa Glu Leu Pro Pro Gly Pro Glu 
                85                  90                  95      


Asp Pro Gly Lys His Leu Phe Glu Ile Ser Pro Gly Gly Ala Gly Glu 
            100                 105                 110         


Arg Glu Lys Val Pro Ala Asn Pro Glu Ala Leu Leu Leu Met Ala Ser 
        115                 120                 125             


Ser Gln Arg Asp Met Glu Asp Trp Val Gln Ala Ile Arg Arg Val Ile 
    130                 135                 140                 


Trp Ala Pro Leu Gly Gly Gly Ile Phe Gly Gln Arg Leu Glu Glu Xaa 
145                 150                 155                 160 


Val His His Glu Arg Lys Tyr Gly Pro Arg Leu Ala Pro Leu Leu Val 
                165                 170                 175     


Glu Gln Cys Val Asp Phe Ile Arg Glu Arg Gly Leu Xaa Glu Glu Gly 
            180                 185                 190         


Leu Phe Arg Met Pro Gly Gln Ala Asn Leu Val Arg Asp Leu Gln Asp 
        195                 200                 205             


Ser Phe Asp Cys Gly Glu Lys Pro Leu Phe Asp Ser Xaa Xaa Asp Val 
    210                 215                 220                 


His Xaa Val Ala Ser Leu Leu Lys Leu Tyr Leu Arg Glu Leu Pro Glu 
225                 230                 235                 240 


Pro Val Val Pro Phe Ala Arg Tyr Glu Asp Phe Leu Ser Cys Ala Gln 
                245                 250                 255     


Leu Leu Xaa Lys Asp Glu Gly Glu Gly Xaa Leu Glu Leu Ala Lys Gln 
            260                 265                 270         


Val Ser Asn Leu Pro Gln Ala Asn Tyr Asn Leu Leu Arg Tyr Ile Cys 
        275                 280                 285             


Lys Phe Leu Asp Glu Val Gln Ala Tyr Ser Asn Val Asn Lys Met Ser 
    290                 295                 300                 


Val Gln Asn Leu Ala Xaa Val Phe Gly Pro Asn Ile Leu Arg Pro Gln 
305                 310                 315                 320 


Val Glu Asp Pro Val Xaa Ile Met Glu Gly Xaa Ser Leu Val Gln His 
                325                 330                 335     


Leu Met Xaa Val Leu Ile Arg Lys His Ser Gln Leu Phe Xaa Ala Pro 
            340                 345                 350         


Val Pro Glu Gly Pro Xaa Ser Pro Arg Gly Gly Leu Gln Cys Ala Val 
        355                 360                 365             


Gly Trp Gly Ser Glu Glu Val Xaa Arg Asp Ser Gln Gly Glu Pro Gly 
    370                 375                 380                 


Gly Pro Gly Leu Pro Ala His Arg Xaa Ser Ser Leu Asp Gly Ala Ala 
385                 390                 395                 400 


Val Ala Val Leu Ser Arg Xaa Ala Pro Xaa Gly Pro Gly Ser Arg Cys 
                405                 410                 415     


Ser Pro Gly Lys Lys Val Gln Xaa Leu Pro Ser Trp Lys Ser Ser Phe 
            420                 425                 430         


Arg Gln Pro Arg Ser Leu Ser Gly Ser Pro Lys Gly Gly Gly Ser Ser 
        435                 440                 445             


Leu Glu Val Pro Ile Ile Ser Ser Gly Gly Asn Trp Leu Met Asn Gly 
    450                 455                 460                 


Leu Ser Ser Leu Arg Gly His Arg Arg Ala Ser Ser Gly Asp Arg Leu 
465                 470                 475                 480 


Lys Asp Ser Gly Ser Val Gln Arg Leu Ser Xaa Tyr Asp Asn Val Pro 
                485                 490                 495     


Ala Pro Gly Leu Val Pro Gly Ile Pro Ser Val Ala Ser Met Ala Trp 
            500                 505                 510         


Ser Gly Ala Ser Ser Ser Glu Ser Ser Val Gly Gly Ser Leu Ser Ser 
        515                 520                 525             


Cys Xaa Ala Cys Arg Ala Ser Asp Ser Ser Ala Arg Ser Ser Leu His 
    530                 535                 540                 


Xaa Asp Trp Ala Leu Glu Pro Ser Pro Leu Pro Ser Ser Ser Glu Asp 
545                 550                 555                 560 


Pro Lys Ser Leu Asp Leu Asp His Ser Met Asp Glu Ala Gly Ala Gly 
                565                 570                 575     


Ala Ser Asn Ser Glu Pro Ser Glu Pro Asp Ser Pro Xaa Arg Glu His 
            580                 585                 590         


Ala Arg Arg Ser Glu Ala Leu Gln Gly Leu Val Xaa Glu Leu Arg Ala 
        595                 600                 605             


Glu Leu Cys Arg Gln Arg Xaa Glu Tyr Glu Arg Ser Val Lys Arg Ile 
    610                 615                 620                 


Glu Glu Gly Ser Ala Asp Leu Arg Lys Arg Met Ser Arg Leu Glu Glu 
625                 630                 635                 640 


Glu Leu Asp Gln Glu Lys Lys Lys Tyr Ile Met Leu Glu Ile Lys Leu 
                645                 650                 655     


Arg Asn Ser Glu Arg Ala Arg Glu Asp Ala Glu Arg Arg Asn Gln Leu 
            660                 665                 670         


Leu Gln Arg Glu Met Glu Glu Phe Phe Ser Xaa Leu Gly Ser Leu Xaa 
        675                 680                 685             


Val Gly Ala Lys Gly Ala Arg Ala Pro Lys 
    690                 695             


<210> 2763
<211> 714
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<400> 2763
Met Leu Ser Pro Lys Ile Arg Gln Ala Arg Arg Ala Arg Ser Lys Ser 
1               5                   10                  15      


Leu Val Met Gly Glu Gln Ser Arg Ser Pro Gly Arg Met Pro Cys Pro 
            20                  25                  30          


His Arg Leu Gly Pro Val Leu Lys Ala Gly Trp Leu Lys Lys Gln Arg 
        35                  40                  45              


Ser Ile Met Lys Asn Trp Gln Gln Arg Trp Phe Val Leu Arg Gly Asp 
    50                  55                  60                  


Gln Leu Phe Tyr Tyr Lys Asp Lys Asp Glu Ile Lys Pro Gln Gly Phe 
65                  70                  75                  80  


Ile Ser Leu Gln Gly Xaa Gln Val Xaa Glu Leu Pro Pro Gly Pro Glu 
                85                  90                  95      


Asp Pro Gly Lys His Leu Phe Glu Ile Ser Pro Gly Gly Ala Gly Glu 
            100                 105                 110         


Arg Glu Lys Val Pro Ala Asn Pro Glu Ala Leu Leu Leu Met Ala Ser 
        115                 120                 125             


Ser Gln Arg Asp Met Glu Asp Trp Val Gln Ala Ile Arg Arg Val Ile 
    130                 135                 140                 


Trp Ala Pro Leu Gly Gly Gly Xaa Ala Arg Arg Ser His Ala His Pro 
145                 150                 155                 160 


Leu Glu Pro Leu Pro Pro Gly Ile Phe Gly Gln Arg Leu Glu Glu Xaa 
                165                 170                 175     


Val His His Glu Arg Lys Tyr Gly Pro Arg Leu Ala Pro Leu Leu Val 
            180                 185                 190         


Glu Gln Cys Val Asp Phe Ile Arg Glu Arg Gly Leu Xaa Glu Glu Gly 
        195                 200                 205             


Leu Phe Arg Met Pro Gly Gln Ala Asn Leu Val Arg Asp Leu Gln Asp 
    210                 215                 220                 


Ser Phe Asp Cys Gly Glu Lys Pro Leu Phe Asp Ser Xaa Xaa Asp Val 
225                 230                 235                 240 


His Xaa Val Ala Ser Leu Leu Lys Leu Tyr Leu Arg Glu Leu Pro Glu 
                245                 250                 255     


Pro Val Val Pro Phe Ala Arg Tyr Glu Asp Phe Leu Ser Cys Ala Gln 
            260                 265                 270         


Leu Leu Xaa Lys Asp Glu Gly Glu Gly Xaa Leu Glu Leu Ala Lys Gln 
        275                 280                 285             


Val Ser Asn Leu Pro Gln Ala Asn Tyr Asn Leu Leu Arg Tyr Ile Cys 
    290                 295                 300                 


Lys Phe Leu Asp Glu Val Gln Ala Tyr Ser Asn Val Asn Lys Met Ser 
305                 310                 315                 320 


Val Gln Asn Leu Ala Xaa Val Phe Gly Pro Asn Ile Leu Arg Pro Gln 
                325                 330                 335     


Val Glu Asp Pro Val Xaa Ile Met Glu Gly Xaa Ser Leu Val Gln His 
            340                 345                 350         


Leu Met Xaa Val Leu Ile Arg Lys His Ser Gln Leu Phe Xaa Ala Pro 
        355                 360                 365             


Val Pro Glu Gly Pro Xaa Ser Pro Arg Gly Gly Leu Gln Cys Ala Val 
    370                 375                 380                 


Gly Trp Gly Ser Glu Glu Val Xaa Arg Asp Ser Gln Gly Glu Pro Gly 
385                 390                 395                 400 


Gly Pro Gly Leu Pro Ala His Arg Xaa Ser Ser Leu Asp Gly Ala Ala 
                405                 410                 415     


Val Ala Val Leu Ser Arg Xaa Ala Pro Xaa Gly Pro Gly Ser Arg Cys 
            420                 425                 430         


Ser Pro Gly Lys Lys Val Gln Xaa Leu Pro Ser Trp Lys Ser Ser Phe 
        435                 440                 445             


Arg Gln Pro Arg Ser Leu Ser Gly Ser Pro Lys Gly Gly Gly Ser Ser 
    450                 455                 460                 


Leu Glu Val Pro Ile Ile Ser Ser Gly Gly Asn Trp Leu Met Asn Gly 
465                 470                 475                 480 


Leu Ser Ser Leu Arg Gly His Arg Arg Ala Ser Ser Gly Asp Arg Leu 
                485                 490                 495     


Lys Asp Ser Gly Ser Val Gln Arg Leu Ser Xaa Tyr Asp Asn Val Pro 
            500                 505                 510         


Ala Pro Gly Leu Val Pro Gly Ile Pro Ser Val Ala Ser Met Ala Trp 
        515                 520                 525             


Ser Gly Ala Ser Ser Ser Glu Ser Ser Val Gly Gly Ser Leu Ser Ser 
    530                 535                 540                 


Cys Xaa Ala Cys Arg Ala Ser Asp Ser Ser Ala Arg Ser Ser Leu His 
545                 550                 555                 560 


Xaa Asp Trp Ala Leu Glu Pro Ser Pro Leu Pro Ser Ser Ser Glu Asp 
                565                 570                 575     


Pro Lys Ser Leu Asp Leu Asp His Ser Met Asp Glu Ala Gly Ala Gly 
            580                 585                 590         


Ala Ser Asn Ser Glu Pro Ser Glu Pro Asp Ser Pro Xaa Arg Glu His 
        595                 600                 605             


Ala Arg Arg Ser Glu Ala Leu Gln Gly Leu Val Xaa Glu Leu Arg Ala 
    610                 615                 620                 


Glu Leu Cys Arg Gln Arg Xaa Glu Tyr Glu Arg Ser Val Lys Arg Ile 
625                 630                 635                 640 


Glu Glu Gly Ser Ala Asp Leu Arg Lys Arg Met Ser Arg Leu Glu Glu 
                645                 650                 655     


Glu Leu Asp Gln Glu Lys Lys Lys Tyr Ile Met Leu Glu Ile Lys Leu 
            660                 665                 670         


Arg Asn Ser Glu Arg Ala Arg Glu Asp Ala Glu Arg Arg Asn Gln Leu 
        675                 680                 685             


Leu Gln Arg Glu Met Glu Glu Phe Phe Ser Xaa Leu Gly Ser Leu Xaa 
    690                 695                 700                 


Val Gly Ala Lys Gly Ala Arg Ala Pro Lys 
705                 710                 


<210> 2764
<211> 608
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<400> 2764
Met Pro Phe Trp Pro Ile Arg Cys Leu Lys Arg Ser Arg Arg Met Pro 
1               5                   10                  15      


Arg Gly Gly Ala Gly Glu Arg Glu Lys Val Pro Ala Asn Pro Glu Ala 
            20                  25                  30          


Leu Leu Leu Met Ala Ser Ser Gln Arg Asp Met Glu Asp Trp Val Gln 
        35                  40                  45              


Ala Ile Arg Arg Val Ile Trp Ala Pro Leu Gly Gly Gly Ile Phe Gly 
    50                  55                  60                  


Gln Arg Leu Glu Glu Xaa Val His His Glu Arg Lys Tyr Gly Pro Arg 
65                  70                  75                  80  


Leu Ala Pro Leu Leu Val Glu Gln Cys Val Asp Phe Ile Arg Glu Arg 
                85                  90                  95      


Gly Leu Xaa Glu Glu Gly Leu Phe Arg Met Pro Gly Gln Ala Asn Leu 
            100                 105                 110         


Val Arg Asp Leu Gln Asp Ser Phe Asp Cys Gly Glu Lys Pro Leu Phe 
        115                 120                 125             


Asp Ser Xaa Xaa Asp Val His Xaa Val Ala Ser Leu Leu Lys Leu Tyr 
    130                 135                 140                 


Leu Arg Glu Leu Pro Glu Pro Val Val Pro Phe Ala Arg Tyr Glu Asp 
145                 150                 155                 160 


Phe Leu Ser Cys Ala Gln Leu Leu Xaa Lys Asp Glu Gly Glu Gly Xaa 
                165                 170                 175     


Leu Glu Leu Ala Lys Gln Val Ser Asn Leu Pro Gln Ala Asn Tyr Asn 
            180                 185                 190         


Leu Leu Arg Tyr Ile Cys Lys Phe Leu Asp Glu Val Gln Ala Tyr Ser 
        195                 200                 205             


Asn Val Asn Lys Met Ser Val Gln Asn Leu Ala Xaa Val Phe Gly Pro 
    210                 215                 220                 


Asn Ile Leu Arg Pro Gln Val Glu Asp Pro Val Xaa Ile Met Glu Gly 
225                 230                 235                 240 


Xaa Ser Leu Val Gln His Leu Met Xaa Val Leu Ile Arg Lys His Ser 
                245                 250                 255     


Gln Leu Phe Xaa Ala Pro Val Pro Glu Gly Pro Xaa Ser Pro Arg Gly 
            260                 265                 270         


Gly Leu Gln Cys Ala Val Gly Trp Gly Ser Glu Glu Val Xaa Arg Asp 
        275                 280                 285             


Ser Gln Gly Glu Pro Gly Gly Pro Gly Leu Pro Ala His Arg Xaa Ser 
    290                 295                 300                 


Ser Leu Asp Gly Ala Ala Val Ala Val Leu Ser Arg Xaa Ala Pro Xaa 
305                 310                 315                 320 


Gly Pro Gly Ser Arg Cys Ser Pro Gly Lys Lys Val Gln Xaa Leu Pro 
                325                 330                 335     


Ser Trp Lys Ser Ser Phe Arg Gln Pro Arg Ser Leu Ser Gly Ser Pro 
            340                 345                 350         


Lys Gly Gly Gly Ser Ser Leu Glu Val Pro Ile Ile Ser Ser Gly Gly 
        355                 360                 365             


Asn Trp Leu Met Asn Gly Leu Ser Ser Leu Arg Gly His Arg Arg Ala 
    370                 375                 380                 


Ser Ser Gly Asp Arg Leu Lys Asp Ser Gly Ser Val Gln Arg Leu Ser 
385                 390                 395                 400 


Xaa Tyr Asp Asn Val Pro Ala Pro Gly Leu Val Pro Gly Ile Pro Ser 
                405                 410                 415     


Val Ala Ser Met Ala Trp Ser Gly Ala Ser Ser Ser Glu Ser Ser Val 
            420                 425                 430         


Gly Gly Ser Leu Ser Ser Cys Xaa Ala Cys Arg Ala Ser Asp Ser Ser 
        435                 440                 445             


Ala Arg Ser Ser Leu His Xaa Asp Trp Ala Leu Glu Pro Ser Pro Leu 
    450                 455                 460                 


Pro Ser Ser Ser Glu Asp Pro Lys Ser Leu Asp Leu Asp His Ser Met 
465                 470                 475                 480 


Asp Glu Ala Gly Ala Gly Ala Ser Asn Ser Glu Pro Ser Glu Pro Asp 
                485                 490                 495     


Ser Pro Xaa Arg Glu His Ala Arg Arg Ser Glu Ala Leu Gln Gly Leu 
            500                 505                 510         


Val Xaa Glu Leu Arg Ala Glu Leu Cys Arg Gln Arg Xaa Glu Tyr Glu 
        515                 520                 525             


Arg Ser Val Lys Arg Ile Glu Glu Gly Ser Ala Asp Leu Arg Lys Arg 
    530                 535                 540                 


Met Ser Arg Leu Glu Glu Glu Leu Asp Gln Glu Lys Lys Lys Tyr Ile 
545                 550                 555                 560 


Met Leu Glu Ile Lys Leu Arg Asn Ser Glu Arg Ala Arg Glu Asp Ala 
                565                 570                 575     


Glu Arg Arg Asn Gln Leu Leu Gln Arg Glu Met Glu Glu Phe Phe Ser 
            580                 585                 590         


Xaa Leu Gly Ser Leu Xaa Val Gly Ala Lys Gly Ala Arg Ala Pro Lys 
        595                 600                 605             


<210> 2765
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<400> 2765
Ile Arg Asp Leu Pro Gly His Tyr Tyr Glu Xaa Leu Lys Phe Leu Val 
1               5                   10                  15      


Gly His Leu Lys Xaa Ile Ala Asp His Ser Glu Lys Asn Lys Met Glu 
            20                  25                  30          


Pro Arg Asn Leu Ala Leu Val Phe Gly Pro Xaa Leu Val Arg Xaa Ser 
        35                  40                  45              


Glu Asp Asn Met Xaa Asp Met Val Xaa His Met Pro Asp Arg Tyr Lys 
    50                  55                  60                  


Ile Val Glu Xaa Leu Ile Gln His Ser Asp Trp Phe Phe Ser Asp Glu 
65                  70                  75                  80  


Glu Asp Lys Gly Glu Arg Ile Leu Pro Pro Val Val Gln Pro Ser Pro 
                85                  90                  95      


Arg Val Arg Gly Pro Pro Arg Arg Ser Arg Xaa Pro Gly Arg Cys Trp 
            100                 105                 110         


Arg Ser Pro Ser Ser Arg Pro Ser Xaa Ala Ser Ala Arg Ser Gly Gly 
        115                 120                 125             


Arg Arg Gly Gly Trp Ala Ala Ala 
    130                 135     


<210> 2766
<211> 102
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<400> 2766
Met Asp Xaa Ile Phe Val Lys Asn Val Lys Glu Asp Gly Pro Ala His 
1               5                   10                  15      


Arg Ala Gly Leu Arg Xaa Gly Asp Arg Leu Val Lys Val Asn Gly Glu 
            20                  25                  30          


Ser Val Ile Gly Lys Xaa Tyr Ser Gln Val Ile Ala Leu Ile Gln Asn 
        35                  40                  45              


Ser Asp Asp Xaa Leu Glu Leu Ser Ile Met Pro Lys Asp Glu Asp Ile 
    50                  55                  60                  


Leu Gln Leu Ala Tyr Ser Gln Asp Ala Tyr Leu Lys Gly Asn Glu Pro 
65                  70                  75                  80  


Tyr Ser Gly Glu Ala Arg Ser Ile Pro Glu Pro Pro Pro Ile Cys Tyr 
                85                  90                  95      


Pro Arg Lys Xaa Tyr Ala 
            100         


<210> 2767
<211> 1144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1107)..(1107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<400> 2767
Met Asn Gly Val Ala Phe Cys Leu Val Gly Ile Pro Pro Arg Pro Glu 
1               5                   10                  15      


Pro Arg Pro Pro Gln Leu Pro Leu Gly Pro Arg Asp Gly Cys Ser Pro 
            20                  25                  30          


Arg Arg Pro Phe Pro Trp Gln Gly Pro Arg Xaa Leu Leu Leu Tyr Lys 
        35                  40                  45              


Ser Pro Gln Asp Gly Phe Gly Phe Xaa Leu Arg His Phe Ile Val Tyr 
    50                  55                  60                  


Pro Pro Glu Ser Ala Val His Cys Ser Leu Lys Glu Glu Glu Asn Gly 
65                  70                  75                  80  


Gly Arg Gly Gly Gly Pro Ser Pro Arg Tyr Arg Leu Glu Pro Met Asp 
                85                  90                  95      


Xaa Ile Phe Val Lys Asn Val Lys Glu Asp Gly Pro Ala His Arg Ala 
            100                 105                 110         


Gly Leu Arg Xaa Gly Asp Arg Leu Val Lys Val Asn Gly Glu Ser Val 
        115                 120                 125             


Ile Gly Lys Xaa Tyr Ser Gln Val Ile Ala Leu Ile Gln Asn Ser Asp 
    130                 135                 140                 


Asp Xaa Leu Glu Leu Ser Ile Met Pro Lys Asp Glu Asp Ile Leu Gln 
145                 150                 155                 160 


Leu Ala Tyr Ser Gln Asp Ala Tyr Leu Lys Gly Asn Glu Pro Tyr Ser 
                165                 170                 175     


Gly Glu Ala Arg Ser Ile Pro Glu Pro Pro Pro Ile Cys Tyr Pro Arg 
            180                 185                 190         


Lys Xaa Tyr Ala Pro Pro Ala Arg Ala Ser Xaa Arg Ala Xaa Met Val 
        195                 200                 205             


Pro Glu Pro Xaa Ser Ala Leu Pro Ser Asp Pro Arg Ser Pro Ala Ala 
    210                 215                 220                 


Trp Ser Asp Pro Gly Leu Arg Val Pro Pro Ala Ala Arg Ala His Leu 
225                 230                 235                 240 


Asp Asn Ser Ser Leu Gly Met Ser Gln Pro Arg Pro Ser Pro Gly Ala 
                245                 250                 255     


Phe Pro His Leu Ser Ser Glu Pro Arg Xaa Pro Arg Ala Phe Pro Glu 
            260                 265                 270         


Pro Gly Ser Arg Val Pro Pro Ser Arg Leu Glu Cys Gln Gln Ala Leu 
        275                 280                 285             


Ser His Trp Leu Ser Asn Gln Val Pro Arg Arg Ala Gly Glu Arg Arg 
    290                 295                 300                 


Cys Pro Ala Met Ala Pro Arg Ala Arg Ser Ala Ser Gln Asp Arg Leu 
305                 310                 315                 320 


Glu Glu Val Ala Ala Pro Arg Pro Trp Pro Cys Ser Xaa Ser Gln Asp 
                325                 330                 335     


Ala Leu Ser Gln Leu Gly Gln Glu Gly Trp His Arg Ala Arg Ser Asp 
            340                 345                 350         


Asp Tyr Leu Ser Arg Ala Xaa Arg Ser Ala Glu Ala Leu Gly Pro Gly 
        355                 360                 365             


Ala Leu Val Ser Pro Arg Phe Glu Arg Cys Gly Trp Ala Ser Gln Arg 
    370                 375                 380                 


Ser Ser Ala Arg Xaa Pro Ala Cys Pro Xaa Arg Asp Leu Pro Gly Pro 
385                 390                 395                 400 


Gln Ala Pro Pro Pro Ser Gly Leu Gln Gly Leu Asp Asp Leu Gly Tyr 
                405                 410                 415     


Ile Gly Tyr Arg Ser Tyr Ser Pro Ser Phe Gln Arg Arg Xaa Gly Leu 
            420                 425                 430         


Leu His Ala Leu Ser Phe Arg Asp Ser Pro Phe Gly Gly Leu Pro Xaa 
        435                 440                 445             


Phe Asn Leu Ala Gln Ser Pro Ala Ser Phe Pro Pro Glu Ala Ser Glu 
    450                 455                 460                 


Pro Pro Arg Val Val Arg Pro Glu Pro Ser Xaa Arg Ala Leu Glu Pro 
465                 470                 475                 480 


Pro Ala Glu Asp Arg Gly Asp Glu Val Val Leu Arg Gln Lys Pro Pro 
                485                 490                 495     


Xaa Gly Arg Lys Val Gln Leu Xaa Pro Ala Arg Gln Met Asn Leu Gly 
            500                 505                 510         


Phe Gly Asp Glu Ser Pro Glu Pro Glu Ala Ser Gly Arg Gly Glu Arg 
        515                 520                 525             


Leu Gly Arg Lys Val Ala Pro Leu Ala Xaa Xaa Glu Asp Ser Leu Ala 
    530                 535                 540                 


Ser Ile Pro Phe Ile Asp Glu Pro Xaa Ser Pro Ser Ile Asp Leu Gln 
545                 550                 555                 560 


Ala Lys His Val Pro Ala Ser Ala Val Val Ser Ser Ala Met Asn Ser 
                565                 570                 575     


Ala Pro Val Leu Gly Xaa Ser Pro Ser Ser Pro Xaa Phe Xaa Phe Xaa 
            580                 585                 590         


Leu Gly Arg His Tyr Ser Gln Asp Cys Ser Ser Ile Lys Ala Gly Arg 
        595                 600                 605             


Arg Ser Ser Tyr Leu Leu Ala Ile Xaa Xaa Glu Arg Ser Lys Ser Cys 
    610                 615                 620                 


Asp Asp Gly Leu Asn Xaa Phe Arg Asp Glu Gly Arg Val Leu Arg Arg 
625                 630                 635                 640 


Leu Pro Asn Arg Ile Pro Ser Leu Arg Met Leu Arg Ser Phe Phe Xaa 
                645                 650                 655     


Asp Gly Ser Leu Asp Ser Trp Gly Xaa Ser Glu Asp Ala Asp Ala Pro 
            660                 665                 670         


Ser Lys Arg His Ser Xaa Ser Asp Leu Ser Asp Ala Xaa Phe Ser Asp 
        675                 680                 685             


Ile Arg Arg Glu Gly Trp Leu Tyr Tyr Lys Gln Ile Leu Xaa Lys Lys 
    690                 695                 700                 


Gly Lys Lys Ala Gly Ser Gly Leu Arg Gln Trp Lys Arg Val Tyr Ala 
705                 710                 715                 720 


Ala Leu Arg Ala Arg Ser Leu Ser Leu Ser Lys Glu Arg Arg Glu Pro 
                725                 730                 735     


Gly Pro Ala Ala Ala Gly Ala Ala Ala Ala Gly Ala Gly Glu Asp Glu 
            740                 745                 750         


Ala Ala Pro Val Cys Ile Gly Ser Cys Leu Val Asp Ile Ser Tyr Ser 
        755                 760                 765             


Glu Xaa Lys Arg Arg His Val Phe Arg Leu Xaa Xaa Ala Asp Phe Cys 
    770                 775                 780                 


Glu Tyr Leu Phe Gln Ala Glu Asp Arg Asp Asp Met Leu Gly Trp Ile 
785                 790                 795                 800 


Arg Ala Ile Arg Glu Asn Ser Arg Ala Glu Gly Glu Asp Pro Gly Cys 
                805                 810                 815     


Ala Asn Gln Ala Leu Ile Ser Lys Lys Leu Asn Asp Tyr Arg Lys Val 
            820                 825                 830         


Ser His Ser Ser Gly Pro Lys Ala Asp Ser Ser Pro Lys Gly Ser Arg 
        835                 840                 845             


Gly Leu Gly Gly Leu Lys Ser Glu Phe Leu Lys Gln Ser Ala Ala Arg 
    850                 855                 860                 


Gly Leu Arg Xaa Gln Asp Leu Pro Ala Gly Ser Lys Asp Asp Ser Ala 
865                 870                 875                 880 


Ala Ala Pro Lys Xaa Pro Trp Gly Ile Asn Ile Ile Lys Lys Asn Lys 
                885                 890                 895     


Lys Ala Ala Pro Arg Ala Phe Gly Val Arg Leu Glu Glu Cys Gln Pro 
            900                 905                 910         


Ala Xaa Glu Asn Gln Arg Val Pro Leu Ile Val Ala Ala Cys Cys Arg 
        915                 920                 925             


Ile Val Glu Ala Arg Gly Leu Glu Ser Xaa Gly Ile Tyr Arg Val Pro 
    930                 935                 940                 


Gly Asn Asn Ala Val Val Ser Ser Leu Gln Glu Gln Leu Asn Arg Gly 
945                 950                 955                 960 


Pro Gly Asp Ile Asn Leu Gln Asp Glu Arg Trp Gln Asp Leu Asn Val 
                965                 970                 975     


Ile Ser Ser Leu Leu Lys Ser Phe Phe Arg Lys Leu Pro Glu Pro Leu 
            980                 985                 990         


Phe Xaa Asp Asp Lys Tyr Asn Asp  Phe Ile Glu Ala Asn  Arg Ile Glu 
        995                 1000                 1005             


Asp Ala  Arg Glu Arg Met Arg  Xaa Leu Arg Lys Leu  Ile Arg Asp 
    1010                 1015                 1020             


Leu Pro  Gly His Tyr Tyr Glu  Xaa Leu Lys Phe Leu  Val Gly His 
    1025                 1030                 1035             


Leu Lys  Xaa Ile Ala Asp His  Ser Glu Lys Asn Lys  Met Glu Pro 
    1040                 1045                 1050             


Arg Asn  Leu Ala Leu Val Phe  Gly Pro Xaa Leu Val  Arg Xaa Ser 
    1055                 1060                 1065             


Glu Asp  Asn Met Xaa Asp Met  Val Xaa His Met Pro  Asp Arg Tyr 
    1070                 1075                 1080             


Lys Ile  Val Glu Xaa Leu Ile  Gln His Ser Asp Trp  Phe Phe Ser 
    1085                 1090                 1095             


Asp Glu  Glu Asp Lys Gly Glu  Arg Xaa Pro Val Gly  Asp Lys Glu 
    1100                 1105                 1110             


Pro Gln  Ala Val Pro Asn Ile  Glu Tyr Leu Leu Pro  Asn Ile Gly 
    1115                 1120                 1125             


Arg Xaa  Val Pro Pro Gly Asp  Pro Gly Ser Ala Asp  Leu Leu Glu 
    1130                 1135                 1140             


Ile 
    


<210> 2768
<211> 1491
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1107)..(1107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1189)..(1189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1243)..(1243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1252)..(1252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1255)..(1255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1287)..(1287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1317)..(1317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1379)..(1379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1396)..(1396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1415)..(1415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1453)..(1453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1471)..(1471)
<223> Selenocysteine

<400> 2768
Met Asn Gly Val Ala Phe Cys Leu Val Gly Ile Pro Pro Arg Pro Glu 
1               5                   10                  15      


Pro Arg Pro Pro Gln Leu Pro Leu Gly Pro Arg Asp Gly Cys Ser Pro 
            20                  25                  30          


Arg Arg Pro Phe Pro Trp Gln Gly Pro Arg Xaa Leu Leu Leu Tyr Lys 
        35                  40                  45              


Ser Pro Gln Asp Gly Phe Gly Phe Xaa Leu Arg His Phe Ile Val Tyr 
    50                  55                  60                  


Pro Pro Glu Ser Ala Val His Cys Ser Leu Lys Glu Glu Glu Asn Gly 
65                  70                  75                  80  


Gly Arg Gly Gly Gly Pro Ser Pro Arg Tyr Arg Leu Glu Pro Met Asp 
                85                  90                  95      


Xaa Ile Phe Val Lys Asn Val Lys Glu Asp Gly Pro Ala His Arg Ala 
            100                 105                 110         


Gly Leu Arg Xaa Gly Asp Arg Leu Val Lys Val Asn Gly Glu Ser Val 
        115                 120                 125             


Ile Gly Lys Xaa Tyr Ser Gln Val Ile Ala Leu Ile Gln Asn Ser Asp 
    130                 135                 140                 


Asp Xaa Leu Glu Leu Ser Ile Met Pro Lys Asp Glu Asp Ile Leu Gln 
145                 150                 155                 160 


Leu Ala Tyr Ser Gln Asp Ala Tyr Leu Lys Gly Asn Glu Pro Tyr Ser 
                165                 170                 175     


Gly Glu Ala Arg Ser Ile Pro Glu Pro Pro Pro Ile Cys Tyr Pro Arg 
            180                 185                 190         


Lys Xaa Tyr Ala Pro Pro Ala Arg Ala Ser Xaa Arg Ala Xaa Met Val 
        195                 200                 205             


Pro Glu Pro Xaa Ser Ala Leu Pro Ser Asp Pro Arg Ser Pro Ala Ala 
    210                 215                 220                 


Trp Ser Asp Pro Gly Leu Arg Val Pro Pro Ala Ala Arg Ala His Leu 
225                 230                 235                 240 


Asp Asn Ser Ser Leu Gly Met Ser Gln Pro Arg Pro Ser Pro Gly Ala 
                245                 250                 255     


Phe Pro His Leu Ser Ser Glu Pro Arg Xaa Pro Arg Ala Phe Pro Glu 
            260                 265                 270         


Pro Gly Ser Arg Val Pro Pro Ser Arg Leu Glu Cys Gln Gln Ala Leu 
        275                 280                 285             


Ser His Trp Leu Ser Asn Gln Val Pro Arg Arg Ala Gly Glu Arg Arg 
    290                 295                 300                 


Cys Pro Ala Met Ala Pro Arg Ala Arg Ser Ala Ser Gln Asp Arg Leu 
305                 310                 315                 320 


Glu Glu Val Ala Ala Pro Arg Pro Trp Pro Cys Ser Xaa Ser Gln Asp 
                325                 330                 335     


Ala Leu Ser Gln Leu Gly Gln Glu Gly Trp His Arg Ala Arg Ser Asp 
            340                 345                 350         


Asp Tyr Leu Ser Arg Ala Xaa Arg Ser Ala Glu Ala Leu Gly Pro Gly 
        355                 360                 365             


Ala Leu Val Ser Pro Arg Phe Glu Arg Cys Gly Trp Ala Ser Gln Arg 
    370                 375                 380                 


Ser Ser Ala Arg Xaa Pro Ala Cys Pro Xaa Arg Asp Leu Pro Gly Pro 
385                 390                 395                 400 


Gln Ala Pro Pro Pro Ser Gly Leu Gln Gly Leu Asp Asp Leu Gly Tyr 
                405                 410                 415     


Ile Gly Tyr Arg Ser Tyr Ser Pro Ser Phe Gln Arg Arg Xaa Gly Leu 
            420                 425                 430         


Leu His Ala Leu Ser Phe Arg Asp Ser Pro Phe Gly Gly Leu Pro Xaa 
        435                 440                 445             


Phe Asn Leu Ala Gln Ser Pro Ala Ser Phe Pro Pro Glu Ala Ser Glu 
    450                 455                 460                 


Pro Pro Arg Val Val Arg Pro Glu Pro Ser Xaa Arg Ala Leu Glu Pro 
465                 470                 475                 480 


Pro Ala Glu Asp Arg Gly Asp Glu Val Val Leu Arg Gln Lys Pro Pro 
                485                 490                 495     


Xaa Gly Arg Lys Val Gln Leu Xaa Pro Ala Arg Gln Met Asn Leu Gly 
            500                 505                 510         


Phe Gly Asp Glu Ser Pro Glu Pro Glu Ala Ser Gly Arg Gly Glu Arg 
        515                 520                 525             


Leu Gly Arg Lys Val Ala Pro Leu Ala Xaa Xaa Glu Asp Ser Leu Ala 
    530                 535                 540                 


Ser Ile Pro Phe Ile Asp Glu Pro Xaa Ser Pro Ser Ile Asp Leu Gln 
545                 550                 555                 560 


Ala Lys His Val Pro Ala Ser Ala Val Val Ser Ser Ala Met Asn Ser 
                565                 570                 575     


Ala Pro Val Leu Gly Xaa Ser Pro Ser Ser Pro Xaa Phe Xaa Phe Xaa 
            580                 585                 590         


Leu Gly Arg His Tyr Ser Gln Asp Cys Ser Ser Ile Lys Ala Gly Arg 
        595                 600                 605             


Arg Ser Ser Tyr Leu Leu Ala Ile Xaa Xaa Glu Arg Ser Lys Ser Cys 
    610                 615                 620                 


Asp Asp Gly Leu Asn Xaa Phe Arg Asp Glu Gly Arg Val Leu Arg Arg 
625                 630                 635                 640 


Leu Pro Asn Arg Ile Pro Ser Leu Arg Met Leu Arg Ser Phe Phe Xaa 
                645                 650                 655     


Asp Gly Ser Leu Asp Ser Trp Gly Xaa Ser Glu Asp Ala Asp Ala Pro 
            660                 665                 670         


Ser Lys Arg His Ser Xaa Ser Asp Leu Ser Asp Ala Xaa Phe Ser Asp 
        675                 680                 685             


Ile Arg Arg Glu Gly Trp Leu Tyr Tyr Lys Gln Ile Leu Xaa Lys Lys 
    690                 695                 700                 


Gly Lys Lys Ala Gly Ser Gly Leu Arg Gln Trp Lys Arg Val Tyr Ala 
705                 710                 715                 720 


Ala Leu Arg Ala Arg Ser Leu Ser Leu Ser Lys Glu Arg Arg Glu Pro 
                725                 730                 735     


Gly Pro Ala Ala Ala Gly Ala Ala Ala Ala Gly Ala Gly Glu Asp Glu 
            740                 745                 750         


Ala Ala Pro Val Cys Ile Gly Ser Cys Leu Val Asp Ile Ser Tyr Ser 
        755                 760                 765             


Glu Xaa Lys Arg Arg His Val Phe Arg Leu Xaa Xaa Ala Asp Phe Cys 
    770                 775                 780                 


Glu Tyr Leu Phe Gln Ala Glu Asp Arg Asp Asp Met Leu Gly Trp Ile 
785                 790                 795                 800 


Arg Ala Ile Arg Glu Asn Ser Arg Ala Glu Gly Glu Asp Pro Gly Cys 
                805                 810                 815     


Ala Asn Gln Ala Leu Ile Ser Lys Lys Leu Asn Asp Tyr Arg Lys Val 
            820                 825                 830         


Ser His Ser Ser Gly Pro Lys Ala Asp Ser Ser Pro Lys Gly Ser Arg 
        835                 840                 845             


Gly Leu Gly Gly Leu Lys Ser Glu Phe Leu Lys Gln Ser Ala Ala Arg 
    850                 855                 860                 


Gly Leu Arg Xaa Gln Asp Leu Pro Ala Gly Ser Lys Asp Asp Ser Ala 
865                 870                 875                 880 


Ala Ala Pro Lys Xaa Pro Trp Gly Ile Asn Ile Ile Lys Lys Asn Lys 
                885                 890                 895     


Lys Ala Ala Pro Arg Ala Phe Gly Val Arg Leu Glu Glu Cys Gln Pro 
            900                 905                 910         


Ala Xaa Glu Asn Gln Arg Val Pro Leu Ile Val Ala Ala Cys Cys Arg 
        915                 920                 925             


Ile Val Glu Ala Arg Gly Leu Glu Ser Xaa Gly Ile Tyr Arg Val Pro 
    930                 935                 940                 


Gly Asn Asn Ala Val Val Ser Ser Leu Gln Glu Gln Leu Asn Arg Gly 
945                 950                 955                 960 


Pro Gly Asp Ile Asn Leu Gln Asp Glu Arg Trp Gln Asp Leu Asn Val 
                965                 970                 975     


Ile Ser Ser Leu Leu Lys Ser Phe Phe Arg Lys Leu Pro Glu Pro Leu 
            980                 985                 990         


Phe Xaa Asp Asp Lys Tyr Asn Asp  Phe Ile Glu Ala Asn  Arg Ile Glu 
        995                 1000                 1005             


Asp Ala  Arg Glu Arg Met Arg  Xaa Leu Arg Lys Leu  Ile Arg Asp 
    1010                 1015                 1020             


Leu Pro  Gly His Tyr Tyr Glu  Xaa Leu Lys Phe Leu  Val Gly His 
    1025                 1030                 1035             


Leu Lys  Xaa Ile Ala Asp His  Ser Glu Lys Asn Lys  Met Glu Pro 
    1040                 1045                 1050             


Arg Asn  Leu Ala Leu Val Phe  Gly Pro Xaa Leu Val  Arg Xaa Ser 
    1055                 1060                 1065             


Glu Asp  Asn Met Xaa Asp Met  Val Xaa His Met Pro  Asp Arg Tyr 
    1070                 1075                 1080             


Lys Ile  Val Glu Xaa Leu Ile  Gln His Ser Asp Trp  Phe Phe Ser 
    1085                 1090                 1095             


Asp Glu  Glu Asp Lys Gly Glu  Arg Xaa Pro Val Gly  Asp Lys Glu 
    1100                 1105                 1110             


Pro Gln  Ala Val Pro Asn Ile  Glu Tyr Leu Leu Pro  Asn Ile Gly 
    1115                 1120                 1125             


Arg Xaa  Val Pro Pro Gly Asp  Pro Gly Ser Asp Ser  Xaa Xaa Cys 
    1130                 1135                 1140             


Ser Ser  Ala Lys Ser Lys Gly  Ser Trp Ala Pro Lys  Lys Glu Pro 
    1145                 1150                 1155             


Tyr Ala  Arg Glu Met Leu Ala  Ile Ser Phe Ile Ser  Ala Val Asn 
    1160                 1165                 1170             


Arg Lys  Arg Lys Lys Arg Arg  Glu Ala Arg Gly Leu  Gly Ser Ser 
    1175                 1180                 1185             


Xaa Asp  Asp Asp Ser Glu Gln  Glu Ala His Lys Pro  Gly Ala Gly 
    1190                 1195                 1200             


Ala Xaa  Ala Pro Gly Xaa Gln  Glu Arg Pro Gln Gly  Pro Leu Pro 
    1205                 1210                 1215             


Gly Ala  Val Ala Pro Glu Ala  Pro Gly Arg Leu Ser  Pro Pro Ala 
    1220                 1225                 1230             


Ala Pro  Glu Glu Arg Pro Ala  Ala Asp Xaa Arg Ser  Ile Val Ser 
    1235                 1240                 1245             


Gly Tyr  Ser Xaa Leu Ser Xaa  Met Asp Arg Ser Val  Cys Ser Gly 
    1250                 1255                 1260             


Ala Ser  Gly Arg Arg Ala Gly  Ala Gly Asp Glu Ala  Asp Asp Glu 
    1265                 1270                 1275             


Arg Ser  Glu Leu Ser His Val  Glu Xaa Asp Xaa Glu  Gly Ala Ala 
    1280                 1285                 1290             


Gly Ala  Gly Pro Gly Gly Arg  Leu Xaa Arg Arg Pro  Ser Phe Ser 
    1295                 1300                 1305             


Ser His  His Leu Met Pro Cys  Asp Xaa Leu Ala Arg  Arg Arg Leu 
    1310                 1315                 1320             


Ala Arg  Gly Arg Pro Asp Gly  Glu Gly Ala Gly Arg  Gly Gly Pro 
    1325                 1330                 1335             


Arg Ala  Pro Glu Pro Pro Gly  Ser Ala Ser Ser Ser  Ser Gln Glu 
    1340                 1345                 1350             


Ser Leu  Arg Pro Pro Ala Ala  Ala Leu Ala Ser Arg  Pro Ser Arg 
    1355                 1360                 1365             


Met Glu  Ala Leu Arg Leu Arg  Leu Arg Gly Xaa Ala  Asp Asp Met 
    1370                 1375                 1380             


Leu Ala  Val Arg Leu Arg Arg  Pro Leu Ser Pro Glu  Xaa Arg Arg 
    1385                 1390                 1395             


Arg Arg  Ser Ser Trp Arg Arg  His Xaa Val Val Val  Gln Ser Pro 
    1400                 1405                 1410             


Leu Xaa  Asp Leu Asn Phe Asn  Glu Trp Lys Glu Leu  Gly Gly Gly 
    1415                 1420                 1425             


Gly Pro  Pro Glu Pro Ala Gly  Ala Arg Ala His Ser  Asp Asn Lys 
    1430                 1435                 1440             


Asp Ser  Gly Leu Ser Ser Leu  Glu Ser Xaa Lys Ala  Arg Ala Pro 
    1445                 1450                 1455             


Ser Ser  Ala Ala Ser Gln Pro  Pro Ala Pro Gly Asp  Xaa Gly Ser 
    1460                 1465                 1470             


Leu Gln  Ser Gln Pro Pro Arg  Arg Ser Ala Ala Ser  Arg Leu His 
    1475                 1480                 1485             


Gln Cys  Leu 
    1490     


<210> 2769
<211> 83
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<400> 2769
Arg Val Pro Leu Ile Val Ala Ala Cys Cys Arg Ile Val Glu Ala Arg 
1               5                   10                  15      


Gly Leu Glu Ser Xaa Gly Ile Tyr Arg Val Pro Gly Asn Asn Ala Val 
            20                  25                  30          


Val Ser Ser Leu Gln Glu Gln Leu Asn Arg Gly Pro Gly Asp Ile Asn 
        35                  40                  45              


Leu Gln Asp Glu Arg Trp Gln Asp Leu Asn Val Ile Ser Ser Leu Leu 
    50                  55                  60                  


Lys Ser Phe Phe Arg Lys Leu Pro Glu Pro Leu Phe Xaa Asp Gly Ala 
65                  70                  75                  80  


Leu Leu Phe 
            


<210> 2770
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<400> 2770
Ser Lys Ser Cys Asp Asp Gly Leu Asn Xaa Phe Arg Asp Glu Gly Arg 
1               5                   10                  15      


Val Leu Arg Arg Leu Pro Asn Arg Ile Pro Ser Leu Arg Met Leu Arg 
            20                  25                  30          


Ser Phe Phe Xaa Asp Gly Ser Leu Asp Ser Trp Gly Xaa Ser Glu Asp 
        35                  40                  45              


Ala Asp Ala Pro Ser Lys Arg His Ser Xaa Ser Asp Leu Ser Asp Ala 
    50                  55                  60                  


Xaa Phe Ser Asp Ile Arg Arg Glu Gly Trp Leu Tyr Tyr Lys Gln Ile 
65                  70                  75                  80  


Leu Xaa Lys Lys Gly Lys Lys Ala Gly Ser Gly Leu Arg Gln Trp Lys 
                85                  90                  95      


Arg Val Tyr Ala Ala Leu Arg Ala Arg Ser Leu Ser Leu Ser Lys Glu 
            100                 105                 110         


Arg Arg Glu Pro Gly Pro Ala Ala Ala Gly Ala Ala Ala Ala Gly Ala 
        115                 120                 125             


Gly 
    


<210> 2771
<211> 64
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(48)
<223> Selenocysteine

<400> 2771
Xaa Phe Phe Ser Asp Glu Glu Asp Lys Gly Glu Arg Xaa Pro Val Gly 
1               5                   10                  15      


Asp Lys Glu Pro Gln Ala Val Pro Asn Ile Glu Tyr Leu Leu Pro Asn 
            20                  25                  30          


Ile Gly Arg Xaa Val Pro Pro Gly Asp Pro Gly Ser Asp Ser Xaa Xaa 
        35                  40                  45              


Cys Ser Ser Ala Lys Ser Lys Val Arg Met Lys Ala Ile Leu Lys Ala 
    50                  55                  60                  


<210> 2772
<211> 163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 2772
Xaa Xaa Phe Ser Asp Ile Arg Arg Glu Gly Trp Leu Tyr Tyr Lys Gln 
1               5                   10                  15      


Ile Leu Xaa Lys Lys Gly Lys Ala Glu Asp Arg Asp Asp Met Leu Gly 
            20                  25                  30          


Trp Ile Arg Ala Ile Arg Glu Asn Ser Arg Ala Glu Gly Glu Asp Pro 
        35                  40                  45              


Gly Cys Ala Asn Gln Ala Leu Ile Ser Lys Lys Leu Asn Asp Tyr Arg 
    50                  55                  60                  


Lys Val Ser His Ser Ser Gly Pro Lys Ala Asp Ser Ser Pro Lys Gly 
65                  70                  75                  80  


Ser Arg Gly Leu Gly Gly Leu Lys Ser Glu Phe Leu Lys Gln Ser Ala 
                85                  90                  95      


Ala Arg Gly Leu Arg Xaa Gln Asp Leu Pro Ala Gly Ser Lys Asp Asp 
            100                 105                 110         


Ser Ala Ala Ala Pro Lys Xaa Pro Trp Gly Ile Asn Ile Ile Lys Lys 
        115                 120                 125             


Asn Lys Lys Ala Ala Pro Arg Ala Phe Gly Val Arg Leu Glu Glu Cys 
    130                 135                 140                 


Gln Pro Ala Xaa Glu Asn Gln Arg Val Pro Leu Ile Val Ala Ala Cys 
145                 150                 155                 160 


Cys Arg Ile 
            


<210> 2773
<211> 748
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<400> 2773
Met Glu Glu Asn Asn Asp Ser Xaa Glu Asn Pro Gln Gln Gly Gln Gly 
1               5                   10                  15      


Arg Gln Asn Ala Ile Lys Cys Gly Trp Leu Arg Lys Gln Gly Gly Phe 
            20                  25                  30          


Val Lys Xaa Trp His Xaa Arg Trp Phe Val Leu Lys Gly Asp Gln Leu 
        35                  40                  45              


Tyr Tyr Phe Lys Asp Glu Asp Glu Xaa Lys Pro Leu Gly Xaa Ile Phe 
    50                  55                  60                  


Leu Pro Gly Asn Lys Val Ser Glu His Pro Cys Asn Glu Glu Asn Pro 
65                  70                  75                  80  


Gly Lys Phe Leu Phe Glu Val Val Pro Gly Gly Asp Arg Asp Arg Met 
                85                  90                  95      


Xaa Ala Asn His Glu Ser Tyr Leu Leu Met Ala Ser Xaa Gln Asn Asp 
            100                 105                 110         


Met Glu Asp Trp Val Lys Ser Ile Arg Arg Val Ile Trp Gly Pro Phe 
        115                 120                 125             


Gly Gly Gly Ile Phe Gly Gln Lys Leu Glu Asp Xaa Val Arg Tyr Glu 
    130                 135                 140                 


Lys Arg Tyr Gly Asn Arg Leu Ala Pro Met Leu Val Glu Gln Cys Val 
145                 150                 155                 160 


Asp Phe Ile Arg Gln Arg Gly Leu Lys Glu Glu Gly Leu Phe Arg Leu 
                165                 170                 175     


Pro Gly Gln Ala Asn Leu Val Lys Glu Leu Gln Asp Ala Phe Asp Cys 
            180                 185                 190         


Gly Glu Lys Pro Ser Phe Asp Ser Asn Xaa Asp Val His Xaa Val Ala 
        195                 200                 205             


Ser Leu Leu Lys Leu Tyr Leu Arg Glu Leu Pro Glu Pro Val Ile Pro 
    210                 215                 220                 


Tyr Ala Lys Tyr Glu Asp Phe Leu Ser Cys Ala Lys Leu Leu Ser Lys 
225                 230                 235                 240 


Glu Glu Glu Ala Gly Val Lys Glu Leu Ala Lys Gln Val Lys Ser Leu 
                245                 250                 255     


Pro Val Val Asn Tyr Asn Leu Leu Lys Tyr Ile Cys Arg Phe Leu Asp 
            260                 265                 270         


Glu Val Gln Ser Tyr Ser Gly Val Asn Lys Met Ser Val Gln Asn Leu 
        275                 280                 285             


Ala Xaa Val Phe Gly Pro Asn Ile Leu Arg Pro Lys Val Glu Asp Pro 
    290                 295                 300                 


Leu Xaa Ile Met Glu Gly Xaa Val Val Val Gln Gln Leu Met Ser Val 
305                 310                 315                 320 


Met Ile Ser Lys His Asp Cys Leu Phe Pro Lys Asp Ala Glu Leu Gln 
                325                 330                 335     


Ser Lys Pro Gln Asp Gly Val Ser Asn Asn Asn Glu Ile Gln Lys Lys 
            340                 345                 350         


Ala Xaa Met Gly Gln Leu Gln Asn Lys Glu Asn Asn Asn Xaa Lys Asp 
        355                 360                 365             


Ser Pro Ser Arg Gln Cys Ser Trp Asp Lys Ser Glu Ser Pro Gln Arg 
    370                 375                 380                 


Ser Ser Met Asn Asn Gly Ser Pro Xaa Ala Leu Ser Gly Ser Lys Xaa 
385                 390                 395                 400 


Asn Ser Pro Lys Asn Ser Val His Lys Leu Asp Val Ser Arg Ser Pro 
                405                 410                 415     


Pro Leu Met Val Lys Lys Asn Pro Ala Phe Asn Lys Gly Ser Gly Ile 
            420                 425                 430         


Val Xaa Asn Gly Ser Phe Ser Ser Ser Asn Ala Glu Gly Leu Glu Lys 
        435                 440                 445             


Xaa Gln Xaa Xaa Pro Asn Gly Ser Leu Gln Ala Arg Arg Ser Ser Ser 
    450                 455                 460                 


Leu Lys Val Ser Gly Xaa Lys Met Gly Xaa His Ser Val Gln Asn Gly 
465                 470                 475                 480 


Xaa Val Arg Met Gly Ile Leu Asn Ser Asp Xaa Leu Gly Asn Pro Xaa 
                485                 490                 495     


Asn Val Arg Asn Met Ser Trp Leu Pro Asn Gly Tyr Val Xaa Leu Arg 
            500                 505                 510         


Asp Asn Lys Gln Lys Glu Gln Ala Gly Glu Leu Gly Gln His Asn Arg 
        515                 520                 525             


Leu Ser Xaa Tyr Asp Asn Val His Gln Gln Phe Ser Met Met Asn Leu 
    530                 535                 540                 


Asp Asp Lys Gln Ser Ile Asp Ser Ala Xaa Trp Ser Xaa Ser Ser Cys 
545                 550                 555                 560 


Glu Ile Ser Leu Pro Glu Asn Ser Asn Ser Cys Arg Ser Ser Xaa Xaa 
                565                 570                 575     


Xaa Cys Pro Glu Gln Asp Phe Phe Gly Gly Asn Phe Glu Asp Pro Val 
            580                 585                 590         


Leu Asp Gly Pro Pro Gln Asp Asp Leu Ser His Pro Arg Asp Tyr Glu 
        595                 600                 605             


Ser Lys Ser Asp His Arg Ser Val Gly Gly Arg Ser Ser Arg Ala Xaa 
    610                 615                 620                 


Ser Ser Ser Asp Asn Ser Glu Xaa Phe Val Gly Asn Ser Ser Ser Asn 
625                 630                 635                 640 


His Ser Ala Leu His Ser Leu Val Ser Ser Leu Lys Gln Glu Met Xaa 
                645                 650                 655     


Lys Gln Lys Ile Glu Tyr Glu Ser Arg Ile Lys Ser Leu Glu Gln Arg 
            660                 665                 670         


Asn Leu Xaa Leu Glu Xaa Glu Met Met Ser Leu His Asp Glu Leu Asp 
        675                 680                 685             


Gln Glu Arg Lys Lys Phe Xaa Met Ile Glu Ile Lys Met Arg Asn Ala 
    690                 695                 700                 


Glu Arg Ala Lys Glu Asp Ala Glu Lys Arg Asn Asp Met Leu Gln Lys 
705                 710                 715                 720 


Glu Met Glu Gln Phe Phe Ser Xaa Phe Gly Glu Leu Xaa Val Glu Pro 
                725                 730                 735     


Arg Arg Xaa Glu Arg Gly Asn Xaa Ile Trp Ile Gln 
            740                 745             


<210> 2774
<211> 246
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<400> 2774
Met Glu Glu Asn Asn Asp Ser Xaa Glu Asn Pro Gln Gln Gly Gln Gly 
1               5                   10                  15      


Arg Gln Asn Ala Ile Lys Cys Gly Trp Leu Arg Lys Gln Gly Gly Phe 
            20                  25                  30          


Val Lys Xaa Trp His Xaa Arg Trp Phe Val Leu Lys Gly Asp Gln Leu 
        35                  40                  45              


Tyr Tyr Phe Lys Asp Glu Asp Glu Xaa Lys Pro Leu Gly Xaa Ile Phe 
    50                  55                  60                  


Leu Pro Gly Asn Lys Val Ser Glu His Pro Cys Asn Glu Glu Asn Pro 
65                  70                  75                  80  


Gly Lys Phe Leu Phe Glu Val Val Pro Gly Gly Asp Arg Asp Arg Met 
                85                  90                  95      


Xaa Ala Asn His Glu Ser Tyr Leu Leu Met Ala Ser Xaa Gln Asn Asp 
            100                 105                 110         


Met Glu Asp Trp Val Lys Ser Ile Arg Arg Val Ile Trp Gly Pro Phe 
        115                 120                 125             


Gly Gly Gly Ile Phe Gly Gln Lys Leu Glu Asp Xaa Val Arg Tyr Glu 
    130                 135                 140                 


Lys Arg Tyr Gly Asn Arg Leu Ala Pro Met Leu Val Glu Gln Cys Val 
145                 150                 155                 160 


Asp Phe Ile Arg Gln Arg Gly Leu Lys Glu Glu Gly Leu Phe Arg Leu 
                165                 170                 175     


Pro Gly Gln Ala Asn Leu Val Lys Glu Leu Gln Asp Ala Phe Asp Cys 
            180                 185                 190         


Gly Glu Lys Pro Ser Phe Asp Ser Asn Xaa Asp Val His Xaa Val Ala 
        195                 200                 205             


Ser Leu Leu Lys Leu Tyr Leu Arg Glu Leu Pro Glu Pro Val Ile Pro 
    210                 215                 220                 


Tyr Ala Lys Tyr Glu Asp Phe Leu Ser Cys Ala Lys Leu Leu Ser Lys 
225                 230                 235                 240 


Glu Glu Glu Ala Val Ser 
                245     


<210> 2775
<211> 622
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<400> 2775
Met Phe Val Gln Gly Gly Asp Arg Asp Arg Met Xaa Ala Asn His Glu 
1               5                   10                  15      


Ser Tyr Leu Leu Met Ala Ser Xaa Gln Asn Asp Met Glu Asp Trp Val 
            20                  25                  30          


Lys Ser Ile Arg Arg Val Ile Trp Gly Pro Phe Gly Gly Gly Ile Phe 
        35                  40                  45              


Gly Gln Lys Leu Glu Asp Xaa Val Arg Tyr Glu Lys Arg Tyr Gly Asn 
    50                  55                  60                  


Arg Leu Ala Pro Met Leu Val Glu Gln Cys Val Asp Phe Ile Arg Gln 
65                  70                  75                  80  


Arg Gly Leu Lys Glu Glu Gly Leu Phe Arg Leu Pro Gly Gln Ala Asn 
                85                  90                  95      


Leu Val Lys Glu Leu Gln Asp Ala Phe Asp Cys Gly Glu Lys Pro Ser 
            100                 105                 110         


Phe Asp Ser Asn Xaa Asp Val His Xaa Val Ala Ser Leu Leu Lys Leu 
        115                 120                 125             


Tyr Leu Arg Glu Leu Pro Glu Pro Val Ile Pro Tyr Ala Lys Tyr Glu 
    130                 135                 140                 


Asp Phe Leu Ser Cys Ala Lys Leu Leu Ser Lys Glu Glu Glu Ala Gly 
145                 150                 155                 160 


Val Lys Glu Leu Ala Lys Gln Val Lys Ser Leu Pro Val Val Asn Tyr 
                165                 170                 175     


Asn Leu Leu Lys Tyr Ile Cys Arg Phe Leu Asp Glu Val Gln Ser Tyr 
            180                 185                 190         


Ser Gly Val Asn Lys Met Ser Val Gln Asn Leu Ala Xaa Val Phe Gly 
        195                 200                 205             


Pro Asn Ile Leu Arg Pro Lys Val Glu Asp Pro Leu Xaa Ile Met Glu 
    210                 215                 220                 


Gly Xaa Val Val Val Gln Gln Leu Met Ser Val Met Ile Ser Lys His 
225                 230                 235                 240 


Asp Cys Leu Phe Pro Lys Asp Ala Glu Leu Gln Ser Lys Pro Gln Asp 
                245                 250                 255     


Gly Val Ser Asn Asn Asn Glu Ile Gln Lys Lys Ala Xaa Met Gly Gln 
            260                 265                 270         


Leu Gln Asn Lys Glu Asn Asn Asn Xaa Lys Asp Ser Pro Ser Arg Gln 
        275                 280                 285             


Cys Ser Trp Asp Lys Ser Glu Ser Pro Gln Arg Ser Ser Met Asn Asn 
    290                 295                 300                 


Gly Ser Pro Xaa Ala Leu Ser Gly Ser Lys Xaa Asn Ser Pro Lys Asn 
305                 310                 315                 320 


Ser Val His Lys Leu Asp Val Ser Arg Ser Pro Pro Leu Met Val Lys 
                325                 330                 335     


Lys Asn Pro Ala Phe Asn Lys Gly Ser Gly Ile Val Xaa Asn Gly Ser 
            340                 345                 350         


Phe Ser Ser Ser Asn Ala Glu Gly Leu Glu Lys Xaa Gln Xaa Xaa Pro 
        355                 360                 365             


Asn Gly Ser Leu Gln Ala Arg Arg Ser Ser Ser Leu Lys Val Ser Gly 
    370                 375                 380                 


Xaa Lys Met Gly Xaa His Ser Val Gln Asn Gly Xaa Val Arg Met Gly 
385                 390                 395                 400 


Ile Leu Asn Ser Asp Xaa Leu Gly Asn Pro Xaa Asn Val Arg Asn Met 
                405                 410                 415     


Ser Trp Leu Pro Asn Gly Tyr Val Xaa Leu Arg Asp Asn Lys Gln Lys 
            420                 425                 430         


Glu Gln Ala Gly Glu Leu Gly Gln His Asn Arg Leu Ser Xaa Tyr Asp 
        435                 440                 445             


Asn Val His Gln Gln Phe Ser Met Met Asn Leu Asp Asp Lys Gln Ser 
    450                 455                 460                 


Ile Asp Ser Ala Xaa Trp Ser Xaa Ser Ser Cys Glu Ile Ser Leu Pro 
465                 470                 475                 480 


Glu Asn Ser Asn Ser Cys Arg Ser Ser Xaa Xaa Xaa Cys Pro Glu Gln 
                485                 490                 495     


Asp Phe Phe Gly Gly Asn Phe Glu Asp Pro Val Leu Asp Gly Pro Pro 
            500                 505                 510         


Gln Asp Asp Leu Ser His Pro Arg Asp Tyr Glu Ser Lys Ser Asp His 
        515                 520                 525             


Arg Ser Val Gly Gly Arg Ser Ser Arg Ala Xaa Ser Ser Ser Asp Asn 
    530                 535                 540                 


Ser Glu Xaa Phe Val Gly Asn Ser Ser Ser Asn His Ser Ala Leu His 
545                 550                 555                 560 


Ser Leu Val Ser Ser Leu Lys Gln Glu Met Xaa Lys Gln Lys Ile Glu 
                565                 570                 575     


Tyr Glu Ser Arg Ile Lys Ser Leu Glu Gln Arg Asn Leu Xaa Leu Glu 
            580                 585                 590         


Xaa Glu Met Met Ser Leu His Asp Glu Leu Asp Gln Glu Arg Lys Lys 
        595                 600                 605             


Phe Xaa Met Ile Glu Ile Lys Met Arg Asn Ala Glu Arg Ala 
    610                 615                 620         


<210> 2776
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 2776
Met Phe Val Gln Gly Ile Phe Gly Gln Lys Leu Glu Asp Xaa Val Arg 
1               5                   10                  15      


Tyr Glu Lys Arg Tyr Gly Asn Arg Leu Ala Pro Met Leu Val Glu Gln 
            20                  25                  30          


Cys Val Asp Phe Ile Arg Gln Arg Gly Leu Lys Glu Glu Gly Leu Phe 
        35                  40                  45              


Arg Leu Pro Gly Gln Ala Asn Leu Val Lys Glu Leu Gln Asp Ala Phe 
    50                  55                  60                  


Asp Cys Gly Glu Lys Pro Ser Phe Asp Ser Asn Xaa Asp Val His Xaa 
65                  70                  75                  80  


Val Ala Ser Leu Leu Lys Leu Tyr Leu Arg Glu Leu Pro Glu Pro Val 
                85                  90                  95      


Ile Pro Tyr Ala Lys Tyr Glu Asp Phe Leu Ser Cys Ala Lys Leu Leu 
            100                 105                 110         


Ser Lys Glu Glu Glu Ala 
        115             


<210> 2777
<211> 655
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<400> 2777
Met Pro Glu Asp Arg Asn Ser Gly Gly Cys Pro Ala Gly Ala Leu Ala 
1               5                   10                  15      


Ser Xaa Pro Phe Ile Pro Lys Xaa Xaa Tyr Arg Arg Ile Lys Arg Cys 
            20                  25                  30          


Phe Ser Phe Arg Lys Gly Ile Phe Gly Gln Lys Leu Glu Asp Xaa Val 
        35                  40                  45              


Arg Tyr Glu Lys Arg Tyr Gly Asn Arg Leu Ala Pro Met Leu Val Glu 
    50                  55                  60                  


Gln Cys Val Asp Phe Ile Arg Gln Arg Gly Leu Lys Glu Glu Gly Leu 
65                  70                  75                  80  


Phe Arg Leu Pro Gly Gln Ala Asn Leu Val Lys Glu Leu Gln Asp Ala 
                85                  90                  95      


Phe Asp Cys Gly Glu Lys Pro Ser Phe Asp Ser Asn Xaa Asp Val His 
            100                 105                 110         


Xaa Val Ala Ser Leu Leu Lys Leu Tyr Leu Arg Glu Leu Pro Glu Pro 
        115                 120                 125             


Val Ile Pro Tyr Ala Lys Tyr Glu Asp Phe Leu Ser Cys Ala Lys Leu 
    130                 135                 140                 


Leu Ser Lys Glu Glu Glu Ala Gly Val Lys Glu Leu Ala Lys Gln Val 
145                 150                 155                 160 


Lys Ser Leu Pro Val Val Asn Tyr Asn Leu Leu Lys Tyr Ile Cys Arg 
                165                 170                 175     


Phe Leu Asp Glu Val Gln Ser Tyr Ser Gly Val Asn Lys Met Ser Val 
            180                 185                 190         


Gln Asn Leu Ala Xaa Val Phe Gly Pro Asn Ile Leu Arg Pro Lys Val 
        195                 200                 205             


Glu Asp Pro Leu Xaa Ile Met Glu Gly Xaa Val Val Val Gln Gln Leu 
    210                 215                 220                 


Met Ser Val Met Ile Ser Lys His Asp Cys Leu Phe Pro Lys Asp Ala 
225                 230                 235                 240 


Glu Leu Gln Ser Lys Pro Gln Asp Gly Val Ser Asn Asn Asn Glu Ile 
                245                 250                 255     


Gln Lys Lys Ala Xaa Met Gly Gln Leu Gln Asn Lys Glu Asn Asn Asn 
            260                 265                 270         


Xaa Lys Asp Ser Pro Ser Arg Gln Cys Ser Trp Asp Lys Ser Glu Ser 
        275                 280                 285             


Pro Gln Arg Ser Ser Met Asn Asn Gly Ser Pro Xaa Ala Leu Ser Gly 
    290                 295                 300                 


Ser Lys Xaa Asn Ser Pro Lys Asn Ser Val His Lys Leu Asp Val Ser 
305                 310                 315                 320 


Arg Ser Pro Pro Leu Met Val Lys Lys Asn Pro Ala Phe Asn Lys Gly 
                325                 330                 335     


Ser Gly Ile Val Xaa Asn Gly Ser Phe Ser Ser Ser Asn Ala Glu Gly 
            340                 345                 350         


Leu Glu Lys Xaa Gln Xaa Xaa Pro Asn Gly Ser Leu Gln Ala Arg Arg 
        355                 360                 365             


Ser Ser Ser Leu Lys Val Ser Gly Xaa Lys Met Gly Xaa His Ser Val 
    370                 375                 380                 


Gln Asn Gly Xaa Val Arg Met Gly Ile Leu Asn Ser Asp Xaa Leu Gly 
385                 390                 395                 400 


Asn Pro Xaa Asn Val Arg Asn Met Ser Trp Leu Pro Asn Gly Tyr Val 
                405                 410                 415     


Xaa Leu Arg Asp Asn Lys Gln Lys Glu Gln Ala Gly Glu Leu Gly Gln 
            420                 425                 430         


His Asn Arg Leu Ser Xaa Tyr Asp Asn Val His Gln Gln Phe Ser Met 
        435                 440                 445             


Met Asn Leu Asp Asp Lys Gln Ser Ile Asp Ser Ala Xaa Trp Ser Xaa 
    450                 455                 460                 


Ser Ser Cys Glu Ile Ser Leu Pro Glu Asn Ser Asn Ser Cys Arg Ser 
465                 470                 475                 480 


Ser Xaa Xaa Xaa Cys Pro Glu Gln Asp Phe Phe Gly Gly Asn Phe Glu 
                485                 490                 495     


Asp Pro Val Leu Asp Gly Pro Pro Gln Asp Asp Leu Ser His Pro Arg 
            500                 505                 510         


Asp Tyr Glu Ser Lys Ser Asp His Arg Ser Val Gly Gly Arg Ser Ser 
        515                 520                 525             


Arg Ala Xaa Ser Ser Ser Asp Asn Ser Glu Xaa Phe Val Gly Asn Ser 
    530                 535                 540                 


Ser Ser Asn His Ser Ala Leu His Ser Leu Val Ser Ser Leu Lys Gln 
545                 550                 555                 560 


Glu Met Xaa Lys Gln Lys Ile Glu Tyr Glu Ser Arg Ile Lys Ser Leu 
                565                 570                 575     


Glu Gln Arg Asn Leu Xaa Leu Glu Xaa Glu Met Met Ser Leu His Asp 
            580                 585                 590         


Glu Leu Asp Gln Glu Arg Lys Lys Phe Xaa Met Ile Glu Ile Lys Met 
        595                 600                 605             


Arg Asn Ala Glu Arg Ala Lys Glu Asp Ala Glu Lys Arg Asn Asp Met 
    610                 615                 620                 


Leu Gln Lys Glu Met Glu Gln Phe Phe Ser Xaa Phe Gly Glu Leu Xaa 
625                 630                 635                 640 


Val Glu Pro Arg Arg Xaa Glu Arg Gly Asn Xaa Ile Trp Ile Gln 
                645                 650                 655 


<210> 2778
<211> 82
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<400> 2778
Met Xaa Ala Asn His Glu Ser Tyr Leu Leu Met Ala Ser Xaa Gln Asn 
1               5                   10                  15      


Asp Met Glu Asp Trp Val Lys Ser Ile Arg Arg Val Ile Trp Gly Pro 
            20                  25                  30          


Phe Gly Gly Gly Ile Phe Gly Gln Lys Leu Glu Asp Xaa Val Arg Tyr 
        35                  40                  45              


Glu Lys Arg Tyr Gly Asn Arg Leu Ala Pro Met Leu Val Glu Gln Cys 
    50                  55                  60                  


Val Asp Phe Ile Arg Gln Arg Gly Leu Lys Glu Glu Gly Leu Phe Arg 
65                  70                  75                  80  


Leu Pro 
        


<210> 2779
<211> 653
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<400> 2779
Met Xaa Ala Asn His Glu Ser Tyr Leu Leu Met Ala Ser Xaa Gln Asn 
1               5                   10                  15      


Asp Met Glu Asp Trp Val Lys Ser Ile Arg Arg Val Ile Trp Gly Pro 
            20                  25                  30          


Phe Gly Gly Gly Ile Phe Gly Gln Lys Leu Glu Asp Xaa Val Arg Tyr 
        35                  40                  45              


Glu Lys Arg Tyr Gly Asn Arg Leu Ala Pro Met Leu Val Glu Gln Cys 
    50                  55                  60                  


Val Asp Phe Ile Arg Gln Arg Gly Leu Lys Glu Glu Gly Leu Phe Arg 
65                  70                  75                  80  


Leu Pro Gly Gln Ala Asn Leu Val Lys Glu Leu Gln Asp Ala Phe Asp 
                85                  90                  95      


Cys Gly Glu Lys Pro Ser Phe Asp Ser Asn Xaa Asp Val His Xaa Val 
            100                 105                 110         


Ala Ser Leu Leu Lys Leu Tyr Leu Arg Glu Leu Pro Glu Pro Val Ile 
        115                 120                 125             


Pro Tyr Ala Lys Tyr Glu Asp Phe Leu Ser Cys Ala Lys Leu Leu Ser 
    130                 135                 140                 


Lys Glu Glu Glu Ala Gly Val Lys Glu Leu Ala Lys Gln Val Lys Ser 
145                 150                 155                 160 


Leu Pro Val Val Asn Tyr Asn Leu Leu Lys Tyr Ile Cys Arg Phe Leu 
                165                 170                 175     


Asp Glu Val Gln Ser Tyr Ser Gly Val Asn Lys Met Ser Val Gln Asn 
            180                 185                 190         


Leu Ala Xaa Val Phe Gly Pro Asn Ile Leu Arg Pro Lys Val Glu Asp 
        195                 200                 205             


Pro Leu Xaa Ile Met Glu Gly Xaa Val Val Val Gln Gln Leu Met Ser 
    210                 215                 220                 


Val Met Ile Ser Lys His Asp Cys Leu Phe Pro Lys Asp Ala Glu Leu 
225                 230                 235                 240 


Gln Ser Lys Pro Gln Asp Gly Val Ser Asn Asn Asn Glu Ile Gln Lys 
                245                 250                 255     


Lys Ala Xaa Met Gly Gln Leu Gln Asn Lys Glu Asn Asn Asn Xaa Lys 
            260                 265                 270         


Asp Ser Pro Ser Arg Gln Cys Ser Trp Asp Lys Ser Glu Ser Pro Gln 
        275                 280                 285             


Arg Ser Ser Met Asn Asn Gly Ser Pro Xaa Ala Leu Ser Gly Ser Lys 
    290                 295                 300                 


Xaa Asn Ser Pro Lys Asn Ser Val His Lys Leu Asp Val Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Leu Met Val Lys Lys Asn Pro Ala Phe Asn Lys Gly Ser Gly 
                325                 330                 335     


Ile Val Xaa Asn Gly Ser Phe Ser Ser Ser Asn Ala Glu Gly Leu Glu 
            340                 345                 350         


Lys Xaa Gln Xaa Xaa Pro Asn Gly Ser Leu Gln Ala Arg Arg Ser Ser 
        355                 360                 365             


Ser Leu Lys Val Ser Gly Xaa Lys Met Gly Xaa His Ser Val Gln Asn 
    370                 375                 380                 


Gly Xaa Val Arg Met Gly Ile Leu Asn Ser Asp Xaa Leu Gly Asn Pro 
385                 390                 395                 400 


Xaa Asn Val Arg Asn Met Ser Trp Leu Pro Asn Gly Tyr Val Xaa Leu 
                405                 410                 415     


Arg Asp Asn Lys Gln Lys Glu Gln Ala Gly Glu Leu Gly Gln His Asn 
            420                 425                 430         


Arg Leu Ser Xaa Tyr Asp Asn Val His Gln Gln Phe Ser Met Met Asn 
        435                 440                 445             


Leu Asp Asp Lys Gln Ser Ile Asp Ser Ala Xaa Trp Ser Xaa Ser Ser 
    450                 455                 460                 


Cys Glu Ile Ser Leu Pro Glu Asn Ser Asn Ser Cys Arg Ser Ser Xaa 
465                 470                 475                 480 


Xaa Xaa Cys Pro Glu Gln Asp Phe Phe Gly Gly Asn Phe Glu Asp Pro 
                485                 490                 495     


Val Leu Asp Gly Pro Pro Gln Asp Asp Leu Ser His Pro Arg Asp Tyr 
            500                 505                 510         


Glu Ser Lys Ser Asp His Arg Ser Val Gly Gly Arg Ser Ser Arg Ala 
        515                 520                 525             


Xaa Ser Ser Ser Asp Asn Ser Glu Xaa Phe Val Gly Asn Ser Ser Ser 
    530                 535                 540                 


Asn His Ser Ala Leu His Ser Leu Val Ser Ser Leu Lys Gln Glu Met 
545                 550                 555                 560 


Xaa Lys Gln Lys Ile Glu Tyr Glu Ser Arg Ile Lys Ser Leu Glu Gln 
                565                 570                 575     


Arg Asn Leu Xaa Leu Glu Xaa Glu Met Met Ser Leu His Asp Glu Leu 
            580                 585                 590         


Asp Gln Glu Arg Lys Lys Phe Xaa Met Ile Glu Ile Lys Met Arg Asn 
        595                 600                 605             


Ala Glu Arg Ala Lys Glu Asp Ala Glu Lys Arg Asn Asp Met Leu Gln 
    610                 615                 620                 


Lys Glu Met Glu Gln Phe Phe Ser Xaa Phe Gly Glu Leu Xaa Val Glu 
625                 630                 635                 640 


Pro Arg Arg Xaa Glu Arg Gly Asn Xaa Ile Trp Ile Gln 
                645                 650             


<210> 2780
<211> 458
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<400> 2780
Met Ser Leu Gly Gln Ser Ala Cys Leu Phe Leu Ser Ile Ala Arg Ser 
1               5                   10                  15      


Arg Ser Val Met Xaa Gly Glu Gln Met Ala Ala Phe His Pro Ser Ser 
            20                  25                  30          


Xaa Pro Asn Pro Leu Glu Arg Pro Ile Lys Met Gly Trp Leu Lys Lys 
        35                  40                  45              


Gln Arg Ser Ile Val Lys Asn Trp Gln Gln Arg Tyr Phe Val Leu Arg 
    50                  55                  60                  


Ala Gln Gln Leu Tyr Tyr Tyr Lys Asp Glu Glu Asp Xaa Lys Pro Gln 
65                  70                  75                  80  


Gly Cys Met Tyr Leu Pro Gly Cys Xaa Ile Lys Glu Ile Ala Xaa Asn 
                85                  90                  95      


Pro Glu Glu Ala Gly Lys Phe Val Phe Glu Ile Ile Pro Ala Ser Trp 
            100                 105                 110         


Asp Gln Asn Arg Met Gly Gln Asp Ser Tyr Val Leu Met Ala Ser Ser 
        115                 120                 125             


Gln Ala Glu Met Glu Glu Trp Val Lys Phe Leu Arg Arg Val Ala Gly 
    130                 135                 140                 


Xaa Pro Cys Gly Ala Val Phe Gly Gln Arg Leu Asp Glu Xaa Val Ala 
145                 150                 155                 160 


Tyr Glu Gln Lys Phe Gly Pro His Leu Val Pro Ile Leu Val Glu Lys 
                165                 170                 175     


Cys Ala Glu Phe Ile Leu Glu His Gly Arg Asn Glu Glu Gly Ile Phe 
            180                 185                 190         


Arg Leu Pro Gly Gln Asp Asn Leu Val Lys Gln Leu Arg Asp Ala Phe 
        195                 200                 205             


Asp Ala Gly Glu Arg Pro Ser Phe Asp Arg Asp Xaa Asp Val His Xaa 
    210                 215                 220                 


Val Ala Ser Leu Leu Lys Leu Tyr Leu Arg Asp Leu Pro Glu Pro Val 
225                 230                 235                 240 


Val Pro Trp Ser Gln Tyr Glu Gly Phe Leu Leu Cys Gly Gln Leu Xaa 
                245                 250                 255     


Asn Ala Asp Glu Ala Lys Ala Gln Gln Glu Leu Met Lys Gln Leu Ser 
            260                 265                 270         


Ile Leu Pro Arg Asp Asn Tyr Ser Leu Leu Ser Tyr Ile Cys Arg Phe 
        275                 280                 285             


Leu His Glu Ile Gln Leu Asn Cys Ala Val Asn Lys Met Ser Val Asp 
    290                 295                 300                 


Asn Leu Ala Xaa Val Ile Gly Val Asn Leu Ile Arg Ser Lys Val Glu 
305                 310                 315                 320 


Asp Pro Ala Val Ile Met Arg Gly Xaa Pro Gln Ile Gln Arg Val Met 
                325                 330                 335     


Xaa Met Met Ile Arg Asp His Glu Val Leu Phe Pro Lys Ser Lys Asp 
            340                 345                 350         


Ile Pro Leu Ser Pro Pro Ala Gln Lys Asn Asp Pro Lys Lys Ala Pro 
        355                 360                 365             


Val Ala Arg Ser Ser Val Gly Trp Asp Ala Xaa Glu Asp Leu Arg Ile 
    370                 375                 380                 


Ser Arg Xaa Asp Ser Phe Ser Ser Met Val Arg Cys Arg Glu Pro Ser 
385                 390                 395                 400 


Cys Phe His Trp Val Leu Pro Leu Val Gln Ala Ile Pro Cys Lys Ala 
                405                 410                 415     


Cys Ser Arg Val Ala Ile Trp Gly Val Leu Gly Asp Ala Val Ala Val 
            420                 425                 430         


Gly Ala Ala Ala Xaa Asp Ser Ser Glu His Xaa Leu Lys Ala Trp Pro 
        435                 440                 445             


Leu Ser Lys Ser Ser Phe Tyr Trp His Leu 
    450                 455             


<210> 2781
<211> 639
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<400> 2781
Met Ser Leu Gly Gln Ser Ala Cys Leu Phe Leu Ser Ile Ala Arg Ser 
1               5                   10                  15      


Arg Ser Val Met Xaa Gly Glu Gln Met Ala Ala Phe His Pro Ser Ser 
            20                  25                  30          


Xaa Pro Asn Pro Leu Glu Arg Pro Ile Lys Met Gly Trp Leu Lys Lys 
        35                  40                  45              


Gln Arg Ser Ile Val Lys Asn Trp Gln Gln Arg Tyr Phe Val Leu Arg 
    50                  55                  60                  


Ala Gln Gln Leu Tyr Tyr Tyr Lys Asp Glu Glu Asp Xaa Lys Pro Gln 
65                  70                  75                  80  


Gly Cys Met Tyr Leu Pro Gly Cys Xaa Ile Lys Glu Ile Ala Xaa Asn 
                85                  90                  95      


Pro Glu Glu Ala Gly Lys Phe Val Phe Glu Ile Ile Pro Ala Ser Trp 
            100                 105                 110         


Asp Gln Asn Arg Met Gly Gln Asp Ser Tyr Val Leu Met Ala Ser Ser 
        115                 120                 125             


Gln Ala Glu Met Glu Glu Trp Val Lys Phe Leu Arg Arg Val Ala Gly 
    130                 135                 140                 


Xaa Pro Cys Gly Ala Val Phe Gly Gln Arg Leu Asp Glu Xaa Val Ala 
145                 150                 155                 160 


Tyr Glu Gln Lys Phe Gly Pro His Leu Val Pro Ile Leu Val Glu Lys 
                165                 170                 175     


Cys Ala Glu Phe Ile Leu Glu His Gly Arg Asn Glu Glu Gly Ile Phe 
            180                 185                 190         


Arg Leu Pro Gly Gln Asp Asn Leu Val Lys Gln Leu Arg Asp Ala Phe 
        195                 200                 205             


Asp Ala Gly Glu Arg Pro Ser Phe Asp Arg Asp Xaa Asp Val His Xaa 
    210                 215                 220                 


Val Ala Ser Leu Leu Lys Leu Tyr Leu Arg Asp Leu Pro Glu Pro Val 
225                 230                 235                 240 


Val Pro Trp Ser Gln Tyr Glu Gly Phe Leu Leu Cys Gly Gln Leu Xaa 
                245                 250                 255     


Asn Ala Asp Glu Ala Lys Ala Gln Gln Glu Leu Met Lys Gln Leu Ser 
            260                 265                 270         


Ile Leu Pro Arg Asp Asn Tyr Ser Leu Leu Ser Tyr Ile Cys Arg Phe 
        275                 280                 285             


Leu His Glu Ile Gln Leu Asn Cys Ala Val Asn Lys Met Ser Val Asp 
    290                 295                 300                 


Asn Leu Ala Xaa Val Ile Gly Val Asn Leu Ile Arg Ser Lys Val Glu 
305                 310                 315                 320 


Asp Pro Ala Val Ile Met Arg Gly Xaa Pro Gln Ile Gln Arg Val Met 
                325                 330                 335     


Xaa Met Met Ile Arg Asp His Glu Val Leu Phe Pro Lys Ser Lys Asp 
            340                 345                 350         


Ile Pro Leu Ser Pro Pro Ala Gln Lys Asn Asp Pro Lys Lys Ala Pro 
        355                 360                 365             


Val Ala Arg Ser Ser Val Gly Trp Asp Ala Xaa Glu Asp Leu Arg Ile 
    370                 375                 380                 


Ser Arg Xaa Asp Ser Phe Ser Ser Met Xaa Ser Asp Ser Asp Xaa Xaa 
385                 390                 395                 400 


Ser Pro Xaa Gly Gln Gln Pro Ser Asp Ala Phe Pro Glu Asp Ser Ser 
                405                 410                 415     


Lys Val Pro Arg Glu Lys Pro Gly Asp Trp Lys Met Gln Ser Arg Lys 
            420                 425                 430         


Arg Xaa Gln Xaa Leu Pro Asn Arg Lys Cys Phe Leu Xaa Ser Ala Phe 
        435                 440                 445             


Gln Gly Ala Asn Ser Ser Lys Met Glu Ile Phe Lys Asn Glu Phe Trp 
    450                 455                 460                 


Ser Pro Ser Ser Glu Ala Lys Ala Gly Glu Gly His Arg Arg Xaa Met 
465                 470                 475                 480 


Ser Gln Asp Leu Arg Gln Leu Ser Asp Ser Gln Arg Xaa Ser Xaa Tyr 
                485                 490                 495     


Asp Asn Val Pro Ser Leu Pro Gly Ser Pro Gly Glu Glu Ala Ser Ala 
            500                 505                 510         


Leu Ser Ser Gln Ala Cys Asp Ser Lys Gly Asp Xaa Leu Ala Ser Pro 
        515                 520                 525             


Asn Ser Glu Xaa Gly Pro Gly Lys Lys Asn Ser Gly Glu Glu Glu Ile 
    530                 535                 540                 


Asp Ser Leu Gln Arg Met Val Gln Glu Leu Arg Lys Glu Ile Glu Xaa 
545                 550                 555                 560 


Gln Lys Gln Met Tyr Glu Glu Gln Ile Lys Asn Leu Glu Lys Glu Asn 
                565                 570                 575     


Tyr Asp Val Trp Ala Lys Val Val Arg Leu Asn Glu Glu Leu Glu Lys 
            580                 585                 590         


Glu Lys Lys Lys Ser Ala Ala Leu Glu Ile Ser Leu Arg Asn Met Glu 
        595                 600                 605             


Arg Ser Arg Glu Asp Val Glu Lys Arg Asn Lys Ala Leu Glu Glu Glu 
    610                 615                 620                 


Val Lys Glu Phe Val Lys Ser Met Lys Glu Pro Lys Xaa Glu Ala 
625                 630                 635                 


<210> 2782
<211> 638
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<400> 2782
Met Ser Leu Gly Gln Ser Ala Cys Leu Phe Leu Ser Ile Ala Arg Ser 
1               5                   10                  15      


Arg Ser Val Met Xaa Gly Glu Gln Met Ala Ala Phe His Pro Ser Ser 
            20                  25                  30          


Xaa Pro Asn Pro Leu Glu Arg Pro Ile Lys Met Gly Trp Leu Lys Lys 
        35                  40                  45              


Gln Arg Ser Ile Val Lys Asn Trp Gln Gln Arg Tyr Phe Val Leu Arg 
    50                  55                  60                  


Ala Gln Gln Leu Tyr Tyr Tyr Lys Asp Glu Glu Asp Xaa Lys Pro Gln 
65                  70                  75                  80  


Gly Cys Met Tyr Leu Pro Gly Cys Xaa Ile Lys Glu Ile Ala Xaa Asn 
                85                  90                  95      


Pro Glu Glu Ala Gly Lys Phe Val Phe Glu Ile Ile Pro Ala Ser Trp 
            100                 105                 110         


Asp Gln Asn Arg Met Gly Gln Asp Ser Tyr Val Leu Met Ala Ser Ser 
        115                 120                 125             


Gln Ala Glu Met Glu Glu Trp Val Lys Phe Leu Arg Arg Val Ala Gly 
    130                 135                 140                 


Xaa Pro Cys Gly Val Phe Gly Gln Arg Leu Asp Glu Xaa Val Ala Tyr 
145                 150                 155                 160 


Glu Gln Lys Phe Gly Pro His Leu Val Pro Ile Leu Val Glu Lys Cys 
                165                 170                 175     


Ala Glu Phe Ile Leu Glu His Gly Arg Asn Glu Glu Gly Ile Phe Arg 
            180                 185                 190         


Leu Pro Gly Gln Asp Asn Leu Val Lys Gln Leu Arg Asp Ala Phe Asp 
        195                 200                 205             


Ala Gly Glu Arg Pro Ser Phe Asp Arg Asp Xaa Asp Val His Xaa Val 
    210                 215                 220                 


Ala Ser Leu Leu Lys Leu Tyr Leu Arg Asp Leu Pro Glu Pro Val Val 
225                 230                 235                 240 


Pro Trp Ser Gln Tyr Glu Gly Phe Leu Leu Cys Gly Gln Leu Xaa Asn 
                245                 250                 255     


Ala Asp Glu Ala Lys Ala Gln Gln Glu Leu Met Lys Gln Leu Ser Ile 
            260                 265                 270         


Leu Pro Arg Asp Asn Tyr Ser Leu Leu Ser Tyr Ile Cys Arg Phe Leu 
        275                 280                 285             


His Glu Ile Gln Leu Asn Cys Ala Val Asn Lys Met Ser Val Asp Asn 
    290                 295                 300                 


Leu Ala Xaa Val Ile Gly Val Asn Leu Ile Arg Ser Lys Val Glu Asp 
305                 310                 315                 320 


Pro Ala Val Ile Met Arg Gly Xaa Pro Gln Ile Gln Arg Val Met Xaa 
                325                 330                 335     


Met Met Ile Arg Asp His Glu Val Leu Phe Pro Lys Ser Lys Asp Ile 
            340                 345                 350         


Pro Leu Ser Pro Pro Ala Gln Lys Asn Asp Pro Lys Lys Ala Pro Val 
        355                 360                 365             


Ala Arg Ser Ser Val Gly Trp Asp Ala Xaa Glu Asp Leu Arg Ile Ser 
    370                 375                 380                 


Arg Xaa Asp Ser Phe Ser Ser Met Xaa Ser Asp Ser Asp Xaa Xaa Ser 
385                 390                 395                 400 


Pro Xaa Gly Gln Gln Pro Ser Asp Ala Phe Pro Glu Asp Ser Ser Lys 
                405                 410                 415     


Val Pro Arg Glu Lys Pro Gly Asp Trp Lys Met Gln Ser Arg Lys Arg 
            420                 425                 430         


Xaa Gln Xaa Leu Pro Asn Arg Lys Cys Phe Leu Xaa Ser Ala Phe Gln 
        435                 440                 445             


Gly Ala Asn Ser Ser Lys Met Glu Ile Phe Lys Asn Glu Phe Trp Ser 
    450                 455                 460                 


Pro Ser Ser Glu Ala Lys Ala Gly Glu Gly His Arg Arg Xaa Met Ser 
465                 470                 475                 480 


Gln Asp Leu Arg Gln Leu Ser Asp Ser Gln Arg Xaa Ser Xaa Tyr Asp 
                485                 490                 495     


Asn Val Pro Ser Leu Pro Gly Ser Pro Gly Glu Glu Ala Ser Ala Leu 
            500                 505                 510         


Ser Ser Gln Ala Cys Asp Ser Lys Gly Asp Xaa Leu Ala Ser Pro Asn 
        515                 520                 525             


Ser Glu Xaa Gly Pro Gly Lys Lys Asn Ser Gly Glu Glu Glu Ile Asp 
    530                 535                 540                 


Ser Leu Gln Arg Met Val Gln Glu Leu Arg Lys Glu Ile Glu Xaa Gln 
545                 550                 555                 560 


Lys Gln Met Tyr Glu Glu Gln Ile Lys Asn Leu Glu Lys Glu Asn Tyr 
                565                 570                 575     


Asp Val Trp Ala Lys Val Val Arg Leu Asn Glu Glu Leu Glu Lys Glu 
            580                 585                 590         


Lys Lys Lys Ser Ala Ala Leu Glu Ile Ser Leu Arg Asn Met Glu Arg 
        595                 600                 605             


Ser Arg Glu Asp Val Glu Lys Arg Asn Lys Ala Leu Glu Glu Glu Val 
    610                 615                 620                 


Lys Glu Phe Val Lys Ser Met Lys Glu Pro Lys Xaa Glu Ala 
625                 630                 635             


<210> 2783
<211> 85
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<400> 2783
Met Ser Leu Gly Gln Ser Ala Cys Leu Phe Leu Ser Ile Ala Arg Ser 
1               5                   10                  15      


Arg Ser Val Met Xaa Gly Glu Gln Met Ala Ala Phe His Pro Ser Ser 
            20                  25                  30          


Xaa Pro Asn Pro Leu Glu Arg Pro Ile Lys Met Gly Trp Leu Lys Lys 
        35                  40                  45              


Gln Arg Ser Ile Val Lys Asn Trp Gln Gln Ser Gly Pro Pro Gly Ser 
    50                  55                  60                  


Xaa Arg Xaa Gly Xaa Val Glu Phe Pro Xaa His Gly Ser Glu Ser Arg 
65                  70                  75                  80  


Leu Ala Xaa Gly Arg 
                85  


<210> 2784
<211> 646
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<400> 2784
Met Ser Leu Lys Leu Pro Arg Asn Trp Asp Phe Asn Leu Lys Val Glu 
1               5                   10                  15      


Ala Ala Lys Ile Ala Arg Ser Arg Ser Val Met Xaa Gly Glu Gln Met 
            20                  25                  30          


Ala Ala Phe His Pro Ser Ser Xaa Pro Asn Pro Leu Glu Arg Pro Ile 
        35                  40                  45              


Lys Met Gly Trp Leu Lys Lys Gln Arg Ser Ile Val Lys Asn Trp Gln 
    50                  55                  60                  


Gln Arg Tyr Phe Val Leu Arg Ala Gln Gln Leu Tyr Tyr Tyr Lys Asp 
65                  70                  75                  80  


Glu Glu Asp Xaa Lys Pro Gln Gly Cys Met Tyr Leu Pro Gly Cys Xaa 
                85                  90                  95      


Ile Lys Glu Ile Ala Xaa Asn Pro Glu Glu Ala Gly Lys Phe Val Phe 
            100                 105                 110         


Glu Ile Ile Pro Ala Ser Trp Asp Gln Asn Arg Met Gly Gln Asp Ser 
        115                 120                 125             


Tyr Val Leu Met Ala Ser Ser Gln Ala Glu Met Glu Glu Trp Val Lys 
    130                 135                 140                 


Phe Leu Arg Arg Val Ala Gly Xaa Pro Cys Gly Ala Val Phe Gly Gln 
145                 150                 155                 160 


Arg Leu Asp Glu Xaa Val Ala Tyr Glu Gln Lys Phe Gly Pro His Leu 
                165                 170                 175     


Val Pro Ile Leu Val Glu Lys Cys Ala Glu Phe Ile Leu Glu His Gly 
            180                 185                 190         


Arg Asn Glu Glu Gly Ile Phe Arg Leu Pro Gly Gln Asp Asn Leu Val 
        195                 200                 205             


Lys Gln Leu Arg Asp Ala Phe Asp Ala Gly Glu Arg Pro Ser Phe Asp 
    210                 215                 220                 


Arg Asp Xaa Asp Val His Xaa Val Ala Ser Leu Leu Lys Leu Tyr Leu 
225                 230                 235                 240 


Arg Asp Leu Pro Glu Pro Val Val Pro Trp Ser Gln Tyr Glu Gly Phe 
                245                 250                 255     


Leu Leu Cys Gly Gln Leu Xaa Asn Ala Asp Glu Ala Lys Ala Gln Gln 
            260                 265                 270         


Glu Leu Met Lys Gln Leu Ser Ile Leu Pro Arg Asp Asn Tyr Ser Leu 
        275                 280                 285             


Leu Ser Tyr Ile Cys Arg Phe Leu His Glu Ile Gln Leu Asn Cys Ala 
    290                 295                 300                 


Val Asn Lys Met Ser Val Asp Asn Leu Ala Xaa Val Ile Gly Val Asn 
305                 310                 315                 320 


Leu Ile Arg Ser Lys Val Glu Asp Pro Ala Val Ile Met Arg Gly Xaa 
                325                 330                 335     


Pro Gln Ile Gln Arg Val Met Xaa Met Met Ile Arg Asp His Glu Val 
            340                 345                 350         


Leu Phe Pro Lys Ser Lys Asp Ile Pro Leu Ser Pro Pro Ala Gln Lys 
        355                 360                 365             


Asn Asp Pro Lys Lys Ala Pro Val Ala Arg Ser Ser Val Gly Trp Asp 
    370                 375                 380                 


Ala Xaa Glu Asp Leu Arg Ile Ser Arg Xaa Asp Ser Phe Ser Ser Met 
385                 390                 395                 400 


Xaa Ser Asp Ser Asp Xaa Xaa Ser Pro Xaa Gly Gln Gln Pro Ser Asp 
                405                 410                 415     


Ala Phe Pro Glu Asp Ser Ser Lys Val Pro Arg Glu Lys Pro Gly Asp 
            420                 425                 430         


Trp Lys Met Gln Ser Arg Lys Arg Xaa Gln Xaa Leu Pro Asn Arg Lys 
        435                 440                 445             


Cys Phe Leu Xaa Ser Ala Phe Gln Gly Ala Asn Ser Ser Lys Met Glu 
    450                 455                 460                 


Ile Phe Lys Asn Glu Phe Trp Ser Pro Ser Ser Glu Ala Lys Ala Gly 
465                 470                 475                 480 


Glu Gly His Arg Arg Xaa Met Ser Gln Asp Leu Arg Gln Leu Ser Asp 
                485                 490                 495     


Ser Gln Arg Xaa Ser Xaa Tyr Asp Asn Val Pro Ser Leu Pro Gly Ser 
            500                 505                 510         


Pro Gly Glu Glu Ala Ser Ala Leu Ser Ser Gln Ala Cys Asp Ser Lys 
        515                 520                 525             


Gly Asp Xaa Leu Ala Ser Pro Asn Ser Glu Xaa Gly Pro Gly Lys Lys 
    530                 535                 540                 


Asn Ser Gly Glu Glu Glu Ile Asp Ser Leu Gln Arg Met Val Gln Glu 
545                 550                 555                 560 


Leu Arg Lys Glu Ile Glu Xaa Gln Lys Gln Met Tyr Glu Glu Gln Ile 
                565                 570                 575     


Lys Asn Leu Glu Lys Glu Asn Tyr Asp Val Trp Ala Lys Val Val Arg 
            580                 585                 590         


Leu Asn Glu Glu Leu Glu Lys Glu Lys Lys Lys Ser Ala Ala Leu Glu 
        595                 600                 605             


Ile Ser Leu Arg Asn Met Glu Arg Ser Arg Glu Asp Val Glu Lys Arg 
    610                 615                 620                 


Asn Lys Ala Leu Glu Glu Glu Val Lys Glu Phe Val Lys Ser Met Lys 
625                 630                 635                 640 


Glu Pro Lys Xaa Glu Ala 
                645     


<210> 2785
<211> 606
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<400> 2785
Met Ser Leu Lys Leu Pro Arg Asn Trp Asp Phe Asn Leu Lys Val Glu 
1               5                   10                  15      


Ala Ala Lys Ile Ala Arg Ser Arg Ser Val Met Xaa Gly Glu Gln Met 
            20                  25                  30          


Ala Ala Phe His Pro Ser Ser Xaa Pro Asn Pro Leu Glu Arg Pro Ile 
        35                  40                  45              


Lys Met Gly Trp Leu Lys Lys Gln Arg Ser Ile Val Lys Asn Trp Gln 
    50                  55                  60                  


Gln Arg Tyr Phe Val Leu Arg Ala Gln Gln Leu Tyr Tyr Tyr Lys Asp 
65                  70                  75                  80  


Glu Glu Asp Xaa Lys Pro Gln Gly Cys Met Tyr Leu Pro Gly Cys Xaa 
                85                  90                  95      


Ile Lys Glu Ile Ala Xaa Asn Pro Glu Glu Ala Gly Lys Phe Val Phe 
            100                 105                 110         


Glu Ile Ile Pro Val Phe Gly Gln Arg Leu Asp Glu Xaa Val Ala Tyr 
        115                 120                 125             


Glu Gln Lys Phe Gly Pro His Leu Val Pro Ile Leu Val Glu Lys Cys 
    130                 135                 140                 


Ala Glu Phe Ile Leu Glu His Gly Arg Asn Glu Glu Gly Ile Phe Arg 
145                 150                 155                 160 


Leu Pro Gly Gln Asp Asn Leu Val Lys Gln Leu Arg Asp Ala Phe Asp 
                165                 170                 175     


Ala Gly Glu Arg Pro Ser Phe Asp Arg Asp Xaa Asp Val His Xaa Val 
            180                 185                 190         


Ala Ser Leu Leu Lys Leu Tyr Leu Arg Asp Leu Pro Glu Pro Val Val 
        195                 200                 205             


Pro Trp Ser Gln Tyr Glu Gly Phe Leu Leu Cys Gly Gln Leu Xaa Asn 
    210                 215                 220                 


Ala Asp Glu Ala Lys Ala Gln Gln Glu Leu Met Lys Gln Leu Ser Ile 
225                 230                 235                 240 


Leu Pro Arg Asp Asn Tyr Ser Leu Leu Ser Tyr Ile Cys Arg Phe Leu 
                245                 250                 255     


His Glu Ile Gln Leu Asn Cys Ala Val Asn Lys Met Ser Val Asp Asn 
            260                 265                 270         


Leu Ala Xaa Val Ile Gly Val Asn Leu Ile Arg Ser Lys Val Glu Asp 
        275                 280                 285             


Pro Ala Val Ile Met Arg Gly Xaa Pro Gln Ile Gln Arg Val Met Xaa 
    290                 295                 300                 


Met Met Ile Arg Asp His Glu Val Leu Phe Pro Lys Ser Lys Asp Ile 
305                 310                 315                 320 


Pro Leu Ser Pro Pro Ala Gln Lys Asn Asp Pro Lys Lys Ala Pro Val 
                325                 330                 335     


Ala Arg Ser Ser Val Gly Trp Asp Ala Xaa Glu Asp Leu Arg Ile Ser 
            340                 345                 350         


Arg Xaa Asp Ser Phe Ser Ser Met Xaa Ser Asp Ser Asp Xaa Xaa Ser 
        355                 360                 365             


Pro Xaa Gly Gln Gln Pro Ser Asp Ala Phe Pro Glu Asp Ser Ser Lys 
    370                 375                 380                 


Val Pro Arg Glu Lys Pro Gly Asp Trp Lys Met Gln Ser Arg Lys Arg 
385                 390                 395                 400 


Xaa Gln Xaa Leu Pro Asn Arg Lys Cys Phe Leu Xaa Ser Ala Phe Gln 
                405                 410                 415     


Gly Ala Asn Ser Ser Lys Met Glu Ile Phe Lys Asn Glu Phe Trp Ser 
            420                 425                 430         


Pro Ser Ser Glu Ala Lys Ala Gly Glu Gly His Arg Arg Xaa Met Ser 
        435                 440                 445             


Gln Asp Leu Arg Gln Leu Ser Asp Ser Gln Arg Xaa Ser Xaa Tyr Asp 
    450                 455                 460                 


Asn Val Pro Ser Leu Pro Gly Ser Pro Gly Glu Glu Ala Ser Ala Leu 
465                 470                 475                 480 


Ser Ser Gln Ala Cys Asp Ser Lys Gly Asp Xaa Leu Ala Ser Pro Asn 
                485                 490                 495     


Ser Glu Xaa Gly Pro Gly Lys Lys Asn Ser Gly Glu Glu Glu Ile Asp 
            500                 505                 510         


Ser Leu Gln Arg Met Val Gln Glu Leu Arg Lys Glu Ile Glu Xaa Gln 
        515                 520                 525             


Lys Gln Met Tyr Glu Glu Gln Ile Lys Asn Leu Glu Lys Glu Asn Tyr 
    530                 535                 540                 


Asp Val Trp Ala Lys Val Val Arg Leu Asn Glu Glu Leu Glu Lys Glu 
545                 550                 555                 560 


Lys Lys Lys Ser Ala Ala Leu Glu Ile Ser Leu Arg Asn Met Glu Arg 
                565                 570                 575     


Ser Arg Glu Asp Val Glu Lys Arg Asn Lys Ala Leu Glu Glu Glu Val 
            580                 585                 590         


Lys Glu Phe Val Lys Ser Met Lys Glu Pro Lys Xaa Glu Ala 
        595                 600                 605     


<210> 2786
<211> 139
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(138)
<223> Selenocysteine

<400> 2786
Met Ser Leu Lys Leu Pro Arg Asn Trp Asp Phe Asn Leu Lys Val Glu 
1               5                   10                  15      


Ala Ala Lys Ile Ala Arg Ser Arg Ser Val Met Xaa Gly Glu Gln Met 
            20                  25                  30          


Ala Ala Phe His Pro Ser Ser Xaa Pro Asn Pro Leu Glu Arg Pro Ile 
        35                  40                  45              


Lys Met Gly Trp Leu Lys Lys Gln Arg Ser Ile Val Lys Asn Trp Gln 
    50                  55                  60                  


Gln Arg Tyr Phe Val Leu Arg Ala Gln Gln Leu Tyr Tyr Tyr Lys Asp 
65                  70                  75                  80  


Glu Glu Asp Xaa Lys Pro Gln Gln Cys Leu Ala Ser Ala Trp Met Arg 
                85                  90                  95      


Leu Trp Pro Met Asn Arg Asn Ser Ala Pro Ile Trp Cys Pro Ser Trp 
            100                 105                 110         


Trp Arg Asn Val Gln Ser Ser Ser Trp Ser Xaa Ala Gly Met Lys Arg 
        115                 120                 125             


Ala Ser Ser Val Cys Leu Gly Arg Xaa Xaa Trp 
    130                 135                 


<210> 2787
<211> 339
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<400> 2787
Met Ser Val Asp Asn Leu Ala Xaa Val Ile Gly Val Asn Leu Ile Arg 
1               5                   10                  15      


Ser Lys Val Glu Asp Pro Ala Val Ile Met Arg Gly Xaa Pro Gln Ile 
            20                  25                  30          


Gln Arg Val Met Xaa Met Met Ile Arg Asp His Glu Val Leu Phe Pro 
        35                  40                  45              


Lys Ser Lys Asp Ile Pro Leu Ser Pro Pro Ala Gln Lys Asn Asp Pro 
    50                  55                  60                  


Lys Lys Ala Pro Val Ala Arg Ser Ser Val Gly Trp Asp Ala Xaa Glu 
65                  70                  75                  80  


Asp Leu Arg Ile Ser Arg Xaa Asp Ser Phe Ser Ser Met Xaa Ser Asp 
                85                  90                  95      


Ser Asp Xaa Xaa Ser Pro Xaa Gly Gln Gln Pro Ser Asp Ala Phe Pro 
            100                 105                 110         


Glu Asp Ser Ser Lys Val Pro Arg Glu Lys Pro Gly Asp Trp Lys Met 
        115                 120                 125             


Gln Ser Arg Lys Arg Xaa Gln Xaa Leu Pro Asn Arg Lys Cys Phe Leu 
    130                 135                 140                 


Xaa Ser Ala Phe Gln Gly Ala Asn Ser Ser Lys Met Glu Ile Phe Lys 
145                 150                 155                 160 


Asn Glu Phe Trp Ser Pro Ser Ser Glu Ala Lys Ala Gly Glu Gly His 
                165                 170                 175     


Arg Arg Xaa Met Ser Gln Asp Leu Arg Gln Leu Ser Asp Ser Gln Arg 
            180                 185                 190         


Xaa Ser Xaa Tyr Asp Asn Val Pro Ser Leu Pro Gly Ser Pro Gly Glu 
        195                 200                 205             


Glu Ala Ser Ala Leu Ser Ser Gln Ala Cys Asp Ser Lys Gly Asp Xaa 
    210                 215                 220                 


Leu Ala Ser Pro Asn Ser Glu Xaa Gly Pro Gly Lys Lys Asn Ser Gly 
225                 230                 235                 240 


Glu Glu Glu Ile Asp Ser Leu Gln Arg Met Val Gln Glu Leu Arg Lys 
                245                 250                 255     


Glu Ile Glu Xaa Gln Lys Gln Met Tyr Glu Glu Gln Ile Lys Asn Leu 
            260                 265                 270         


Glu Lys Glu Asn Tyr Asp Val Trp Ala Lys Val Val Arg Leu Asn Glu 
        275                 280                 285             


Glu Leu Glu Lys Glu Lys Lys Lys Ser Ala Ala Leu Glu Ile Ser Leu 
    290                 295                 300                 


Arg Asn Met Glu Arg Ser Arg Glu Asp Val Glu Lys Arg Asn Lys Ala 
305                 310                 315                 320 


Leu Glu Glu Glu Val Lys Glu Phe Val Lys Ser Met Lys Glu Pro Lys 
                325                 330                 335     


Xaa Glu Ala 
            


<210> 2788
<211> 283
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<400> 2788
Met Xaa Gly Glu Gln Met Ala Ala Phe His Pro Ser Ser Xaa Pro Asn 
1               5                   10                  15      


Pro Leu Glu Arg Pro Ile Lys Met Gly Trp Leu Lys Lys Gln Arg Ser 
            20                  25                  30          


Ile Val Lys Asn Trp Gln Gln Arg Tyr Phe Val Leu Arg Ala Gln Gln 
        35                  40                  45              


Leu Tyr Tyr Tyr Lys Asp Glu Glu Asp Xaa Lys Pro Gln Gly Cys Met 
    50                  55                  60                  


Tyr Leu Pro Gly Cys Xaa Ile Lys Glu Ile Ala Xaa Asn Pro Glu Glu 
65                  70                  75                  80  


Ala Gly Lys Phe Val Phe Glu Ile Ile Pro Ala Ser Trp Asp Gln Asn 
                85                  90                  95      


Arg Met Gly Gln Asp Ser Tyr Val Leu Met Ala Ser Ser Gln Ala Glu 
            100                 105                 110         


Met Glu Glu Trp Val Lys Phe Leu Arg Arg Val Ala Gly Xaa Pro Cys 
        115                 120                 125             


Gly Ala Val Phe Gly Gln Arg Leu Asp Glu Xaa Val Ala Tyr Glu Gln 
    130                 135                 140                 


Lys Phe Gly Pro His Leu Val Pro Ile Leu Val Glu Lys Cys Ala Glu 
145                 150                 155                 160 


Phe Ile Leu Glu His Gly Arg Asn Glu Glu Gly Ile Phe Arg Leu Pro 
                165                 170                 175     


Gly Gln Asp Asn Leu Val Lys Gln Leu Arg Asp Ala Phe Asp Ala Gly 
            180                 185                 190         


Glu Arg Pro Ser Phe Asp Arg Asp Xaa Asp Val His Xaa Val Ala Ser 
        195                 200                 205             


Leu Leu Lys Leu Tyr Leu Arg Asp Leu Pro Glu Pro Val Val Pro Trp 
    210                 215                 220                 


Ser Gln Tyr Glu Gly Phe Leu Leu Cys Gly Gln Leu Xaa Asn Ala Asp 
225                 230                 235                 240 


Glu Ala Lys Asn Tyr Arg Asn Arg Asn Asp Cys Gln Ser Val Val Ser 
                245                 250                 255     


Ala Gln Ile His Gln Phe Cys Pro Arg Val Ser Leu Leu Ala His Gly 
            260                 265                 270         


Gln Ala His Leu Leu Val Asn Asp Leu Leu Val 
        275                 280             


<210> 2789
<211> 505
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<400> 2789
Xaa Ala Gln Asn Asp Gly Gln Val Leu Phe Ala Leu Ser Ser Ala Val 
1               5                   10                  15      


Phe Gly Gln Arg Leu Asp Glu Xaa Val Ala Tyr Glu Gln Lys Phe Gly 
            20                  25                  30          


Pro His Leu Val Pro Ile Leu Val Glu Lys Cys Ala Glu Phe Ile Leu 
        35                  40                  45              


Glu His Gly Arg Asn Glu Glu Gly Ile Phe Arg Leu Pro Gly Gln Asp 
    50                  55                  60                  


Asn Leu Val Lys Gln Leu Arg Asp Ala Phe Asp Ala Gly Glu Arg Pro 
65                  70                  75                  80  


Ser Phe Asp Arg Asp Xaa Asp Val His Xaa Val Ala Ser Leu Leu Lys 
                85                  90                  95      


Leu Tyr Leu Arg Asp Leu Pro Glu Pro Val Val Pro Trp Ser Gln Tyr 
            100                 105                 110         


Glu Gly Phe Leu Leu Cys Gly Gln Leu Xaa Asn Ala Asp Glu Ala Lys 
        115                 120                 125             


Ala Gln Gln Glu Leu Met Lys Gln Leu Ser Ile Leu Pro Arg Asp Asn 
    130                 135                 140                 


Tyr Ser Leu Leu Ser Tyr Ile Cys Arg Phe Leu His Glu Ile Gln Leu 
145                 150                 155                 160 


Asn Cys Ala Val Asn Lys Met Ser Val Asp Asn Leu Ala Xaa Val Ile 
                165                 170                 175     


Gly Val Asn Leu Ile Arg Ser Lys Val Glu Asp Pro Ala Val Ile Met 
            180                 185                 190         


Arg Gly Xaa Pro Gln Ile Gln Arg Val Met Xaa Met Met Ile Arg Asp 
        195                 200                 205             


His Glu Val Leu Phe Pro Lys Ser Lys Asp Ile Pro Leu Ser Pro Pro 
    210                 215                 220                 


Ala Gln Lys Asn Asp Pro Lys Lys Ala Pro Val Ala Arg Ser Ser Val 
225                 230                 235                 240 


Gly Trp Asp Ala Xaa Glu Asp Leu Arg Ile Ser Arg Xaa Asp Ser Phe 
                245                 250                 255     


Ser Ser Met Xaa Ser Asp Ser Asp Xaa Xaa Ser Pro Xaa Gly Gln Gln 
            260                 265                 270         


Pro Ser Asp Ala Phe Pro Glu Asp Ser Ser Lys Val Pro Arg Glu Lys 
        275                 280                 285             


Pro Gly Asp Trp Lys Met Gln Ser Arg Lys Arg Xaa Gln Xaa Leu Pro 
    290                 295                 300                 


Asn Arg Lys Cys Phe Leu Xaa Ser Ala Phe Gln Gly Ala Asn Ser Ser 
305                 310                 315                 320 


Lys Met Glu Ile Phe Lys Asn Glu Phe Trp Ser Pro Ser Ser Glu Ala 
                325                 330                 335     


Lys Ala Gly Glu Gly His Arg Arg Xaa Met Ser Gln Asp Leu Arg Gln 
            340                 345                 350         


Leu Ser Asp Ser Gln Arg Xaa Ser Xaa Tyr Asp Asn Val Pro Ser Leu 
        355                 360                 365             


Pro Gly Ser Pro Gly Glu Glu Ala Ser Ala Leu Ser Ser Gln Ala Cys 
    370                 375                 380                 


Asp Ser Lys Gly Asp Xaa Leu Ala Ser Pro Asn Ser Glu Xaa Gly Pro 
385                 390                 395                 400 


Gly Lys Lys Asn Ser Gly Glu Glu Glu Ile Asp Ser Leu Gln Arg Met 
                405                 410                 415     


Val Gln Glu Leu Arg Lys Glu Ile Glu Xaa Gln Lys Gln Met Tyr Glu 
            420                 425                 430         


Glu Gln Ile Lys Asn Leu Glu Lys Glu Asn Tyr Asp Val Trp Ala Lys 
        435                 440                 445             


Val Val Arg Leu Asn Glu Glu Leu Glu Lys Glu Lys Lys Lys Ser Ala 
    450                 455                 460                 


Ala Leu Glu Ile Ser Leu Arg Asn Met Glu Arg Ser Arg Glu Asp Val 
465                 470                 475                 480 


Glu Lys Arg Asn Lys Ala Leu Glu Glu Glu Val Lys Glu Phe Val Lys 
                485                 490                 495     


Ser Met Lys Glu Pro Lys Xaa Glu Ala 
            500                 505 


<210> 2790
<211> 97
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<400> 2790
Ala Lys Leu Glu Asn Gln Glu Ser Arg Val Ser Glu Ile His Ser Leu 
1               5                   10                  15      


Val His Arg Leu Pro Glu Lys Asn Arg Gln Met Leu Gln Leu Leu Met 
            20                  25                  30          


Asn His Leu Ala Lys Tyr Ala Gly Gly Leu Gly Lys Lys Cys Val Lys 
        35                  40                  45              


Cys Ser Leu Gln Trp Arg Xaa Ala Ala Asn Ala Arg Trp Pro Ser Gln 
    50                  55                  60                  


Arg Met Leu Gly Lys Cys Ser Cys Asn Gln Ala Xaa Lys Gln Ser Phe 
65                  70                  75                  80  


Gln Gly Asp Phe Xaa Tyr Gly Asp Gln Gly Gln Ile Gly Val Cys Cys 
                85                  90                  95      


Pro 
    


<210> 2791
<211> 127
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<400> 2791
Ile Val Ile Glu Ile Leu Ile Glu Asn His Glu Lys Ile Phe Asn Xaa 
1               5                   10                  15      


Val Pro Asp Met Pro Leu Xaa Asn Ala Gln Leu His Leu Ser Arg Lys 
            20                  25                  30          


Lys Ser Ser Asp Ser Lys Pro Pro Ser Cys Ser Glu Arg Pro Leu Xaa 
        35                  40                  45              


Leu Phe His Xaa Val Gln Ser Xaa Glu Lys Gln Glu Gln Arg Asn Ser 
    50                  55                  60                  


Ile Ile Asn Ser Ser Leu Glu Ser Val Ser Ser Asn Pro Asn Ser Ile 
65                  70                  75                  80  


Leu Asn Ser Ser Ser Ser Leu Gln Pro Asn Met Asn Ser Ser Asp Pro 
                85                  90                  95      


Asp Leu Ala Val Val Lys Pro Xaa Arg Pro Asn Ser Leu Val Gln Pro 
            100                 105                 110         


Pro Arg Gln Leu Cys Ser Leu Pro Ser Lys Pro Ala Leu Ala Phe 
        115                 120                 125         


<210> 2792
<211> 166
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 2792
Met Glu Pro Leu Ala Pro Ser Pro Arg Ile Trp Xaa Cys Val Phe Tyr 
1               5                   10                  15      


Phe Gly Ile Glu Ser Glu Glu Asp Leu Ser Ser Ala Lys Arg Lys Phe 
            20                  25                  30          


Ala Asp Ser Leu Asn Glu Phe Lys Phe Gln Cys Ile Gly Asp Ala Glu 
        35                  40                  45              


Xaa Asp Asp Glu Met Cys Ile Ala Arg Ser Leu Gln Glu Phe Ala Xaa 
    50                  55                  60                  


Val Leu Arg Asn Leu Glu Asp Glu Arg Ile Arg Met Ile Glu Asn Ala 
65                  70                  75                  80  


Ser Glu Val Leu Ile Xaa Pro Leu Glu Lys Phe Arg Lys Glu Gln Ile 
                85                  90                  95      


Gly Ala Ala Lys Glu Ala Lys Lys Lys Tyr Asp Lys Glu Xaa Glu Lys 
            100                 105                 110         


Tyr Cys Gly Ile Leu Glu Lys His Leu Asn Leu Ser Ser Lys Lys Lys 
        115                 120                 125             


Glu Ser Gln Leu Gln Glu Ala Asp Ser Gln Val Asp Leu Val Arg Gln 
    130                 135                 140                 


His Phe Tyr Glu Val Ser Leu Glu Tyr Val Phe Lys Val Gln Glu Val 
145                 150                 155                 160 


Gln Glu Arg Lys Met Phe 
                165     


<210> 2793
<211> 759
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<400> 2793
Met Gly Leu Pro Ala Leu Glu Phe Ser Asp Cys Cys Leu Asp Ser Pro 
1               5                   10                  15      


His Phe Arg Glu Xaa Leu Lys Ser His Glu Ala Glu Leu Asp Lys Xaa 
            20                  25                  30          


Asn Lys Phe Ile Lys Glu Leu Ile Lys Asp Gly Lys Ser Leu Ile Ser 
        35                  40                  45              


Ala Leu Lys Asn Leu Ser Ser Ala Lys Arg Lys Phe Ala Asp Ser Leu 
    50                  55                  60                  


Asn Glu Phe Lys Phe Gln Cys Ile Gly Asp Ala Glu Xaa Asp Asp Glu 
65                  70                  75                  80  


Met Cys Ile Ala Arg Ser Leu Gln Glu Phe Ala Xaa Val Leu Arg Asn 
                85                  90                  95      


Leu Glu Asp Glu Arg Ile Arg Met Ile Glu Asn Ala Ser Glu Val Leu 
            100                 105                 110         


Ile Xaa Pro Leu Glu Lys Phe Arg Lys Glu Gln Ile Gly Ala Ala Lys 
        115                 120                 125             


Glu Ala Lys Lys Lys Tyr Asp Lys Glu Xaa Glu Lys Tyr Cys Gly Ile 
    130                 135                 140                 


Leu Glu Lys His Leu Asn Leu Ser Ser Lys Lys Lys Glu Ser Gln Leu 
145                 150                 155                 160 


Gln Glu Ala Asp Ser Gln Val Asp Leu Val Arg Gln His Phe Tyr Glu 
                165                 170                 175     


Val Ser Leu Glu Tyr Val Phe Lys Val Gln Glu Val Gln Glu Arg Lys 
            180                 185                 190         


Met Phe Glu Phe Val Glu Pro Leu Leu Ala Phe Leu Gln Gly Leu Phe 
        195                 200                 205             


Xaa Phe Tyr His His Gly Tyr Glu Leu Ala Lys Asp Phe Gly Asp Phe 
    210                 215                 220                 


Lys Xaa Gln Leu Xaa Ile Ser Ile Gln Asn Xaa Arg Asn Arg Phe Glu 
225                 230                 235                 240 


Gly Xaa Arg Ser Glu Val Glu Ser Leu Met Lys Lys Met Lys Glu Asn 
                245                 250                 255     


Pro Leu Glu His Lys Xaa Ile Ser Pro Tyr Xaa Met Glu Gly Tyr Leu 
            260                 265                 270         


Tyr Val Gln Glu Lys Arg His Phe Gly Xaa Ser Trp Val Lys His Tyr 
        275                 280                 285             


Cys Xaa Tyr Gln Arg Asp Ser Lys Gln Ile Xaa Met Val Pro Phe Asp 
    290                 295                 300                 


Gln Lys Ser Gly Gly Lys Gly Gly Glu Asp Glu Ser Val Ile Leu Lys 
305                 310                 315                 320 


Ser Cys Xaa Arg Arg Lys Xaa Asp Ser Ile Glu Lys Arg Phe Cys Phe 
                325                 330                 335     


Asp Val Glu Ala Val Asp Arg Pro Gly Val Ile Xaa Met Gln Ala Leu 
            340                 345                 350         


Ser Glu Glu Asp Arg Arg Leu Trp Met Glu Ala Met Asp Gly Arg Glu 
        355                 360                 365             


Pro Val Tyr Asn Ser Asn Lys Asp Ser Gln Ser Glu Gly Xaa Ala Gln 
    370                 375                 380                 


Leu Asp Ser Ile Gly Phe Ser Ile Ile Arg Lys Cys Ile His Ala Val 
385                 390                 395                 400 


Glu Xaa Arg Gly Ile Asn Glu Gln Gly Leu Tyr Arg Ile Val Gly Val 
                405                 410                 415     


Asn Ser Arg Val Gln Lys Leu Leu Ser Val Leu Met Asp Pro Lys Xaa 
            420                 425                 430         


Ala Ser Glu Xaa Glu Xaa Asp Ile Cys Ala Glu Trp Glu Ile Lys Xaa 
        435                 440                 445             


Ile Xaa Ser Ala Leu Lys Xaa Tyr Leu Arg Met Leu Pro Gly Pro Leu 
    450                 455                 460                 


Met Met Tyr Gln Phe Gln Arg Ser Phe Ile Lys Ala Ala Lys Leu Glu 
465                 470                 475                 480 


Asn Gln Glu Ser Arg Val Ser Glu Ile His Ser Leu Val His Arg Leu 
                485                 490                 495     


Pro Glu Lys Asn Arg Gln Met Leu Gln Leu Leu Met Asn His Leu Ala 
            500                 505                 510         


Asn Val Ala Asn Asn His Lys Gln Asn Leu Met Xaa Val Ala Asn Leu 
        515                 520                 525             


Gly Val Val Phe Gly Pro Xaa Leu Leu Arg Pro Gln Glu Glu Xaa Val 
    530                 535                 540                 


Ala Ala Ile Met Asp Ile Lys Phe Gln Asn Ile Val Ile Glu Ile Leu 
545                 550                 555                 560 


Ile Glu Asn His Glu Lys Ile Phe Asn Xaa Val Pro Asp Met Pro Leu 
                565                 570                 575     


Xaa Asn Ala Gln Leu His Leu Ser Arg Lys Lys Ser Ser Asp Ser Lys 
            580                 585                 590         


Pro Pro Ser Cys Ser Glu Arg Pro Leu Xaa Leu Phe His Xaa Val Gln 
        595                 600                 605             


Ser Xaa Glu Lys Gln Glu Gln Arg Asn Ser Ile Ile Asn Ser Ser Leu 
    610                 615                 620                 


Glu Ser Val Ser Ser Asn Pro Asn Ser Ile Leu Asn Ser Ser Ser Ser 
625                 630                 635                 640 


Leu Gln Pro Asn Met Asn Ser Ser Asp Pro Asp Leu Ala Val Val Lys 
                645                 650                 655     


Pro Xaa Arg Pro Asn Ser Leu Pro Pro Asn Pro Ser Pro Xaa Ser Pro 
            660                 665                 670         


Leu Ser Pro Ser Trp Pro Met Phe Ser Ala Pro Ser Ser Pro Met Pro 
        675                 680                 685             


Xaa Ser Ser Xaa Ser Ser Asp Ser Ser Pro Val Ser Xaa Pro Phe Arg 
    690                 695                 700                 


Lys Ala Lys Ala Leu Tyr Ala Cys Lys Ala Glu His Asp Ser Glu Leu 
705                 710                 715                 720 


Ser Phe Xaa Ala Gly Xaa Val Phe Asp Asn Val His Pro Ser Gln Glu 
                725                 730                 735     


Pro Gly Trp Leu Glu Gly Xaa Leu Asn Gly Lys Xaa Gly Leu Ile Pro 
            740                 745                 750         


Glu Asn Tyr Val Glu Phe Leu 
        755                 


<210> 2794
<211> 814
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<400> 2794
Met Gly Leu Pro Ala Leu Glu Phe Ser Asp Cys Cys Leu Asp Ser Pro 
1               5                   10                  15      


His Phe Arg Glu Xaa Leu Lys Ser His Glu Ala Glu Leu Asp Lys Xaa 
            20                  25                  30          


Asn Lys Phe Ile Lys Glu Leu Ile Lys Asp Gly Lys Ser Leu Ile Ser 
        35                  40                  45              


Ala Leu Lys Asn Leu Ser Ser Ala Lys Arg Lys Phe Ala Asp Ser Leu 
    50                  55                  60                  


Asn Glu Phe Lys Phe Gln Cys Ile Gly Asp Ala Glu Xaa Asp Asp Glu 
65                  70                  75                  80  


Met Cys Ile Ala Arg Ser Leu Gln Glu Phe Ala Xaa Val Leu Arg Asn 
                85                  90                  95      


Leu Glu Asp Glu Arg Ile Arg Met Ile Glu Asn Ala Ser Glu Val Leu 
            100                 105                 110         


Ile Xaa Pro Leu Glu Lys Phe Arg Lys Glu Gln Ile Gly Ala Ala Lys 
        115                 120                 125             


Glu Ala Lys Lys Lys Tyr Asp Lys Glu Xaa Glu Lys Tyr Cys Gly Ile 
    130                 135                 140                 


Leu Glu Lys His Leu Asn Leu Ser Ser Lys Lys Lys Glu Ser Gln Leu 
145                 150                 155                 160 


Gln Glu Ala Asp Ser Gln Val Asp Leu Val Arg Gln His Phe Tyr Glu 
                165                 170                 175     


Val Ser Leu Glu Tyr Val Phe Lys Val Gln Glu Val Gln Glu Arg Lys 
            180                 185                 190         


Met Phe Glu Phe Val Glu Pro Leu Leu Ala Phe Leu Gln Gly Leu Phe 
        195                 200                 205             


Xaa Phe Tyr His His Gly Tyr Glu Leu Ala Lys Asp Phe Gly Asp Phe 
    210                 215                 220                 


Lys Xaa Gln Leu Xaa Ile Ser Ile Gln Asn Xaa Arg Asn Arg Phe Glu 
225                 230                 235                 240 


Gly Xaa Arg Ser Glu Val Glu Ser Leu Met Lys Lys Met Lys Glu Asn 
                245                 250                 255     


Pro Leu Glu His Lys Xaa Ile Ser Pro Tyr Xaa Met Glu Gly Tyr Leu 
            260                 265                 270         


Tyr Val Gln Glu Lys Arg His Phe Gly Xaa Ser Trp Val Lys His Tyr 
        275                 280                 285             


Cys Xaa Tyr Gln Arg Asp Ser Lys Gln Ile Xaa Met Val Pro Phe Asp 
    290                 295                 300                 


Gln Lys Ser Gly Gly Lys Gly Gly Glu Asp Glu Ser Val Ile Leu Lys 
305                 310                 315                 320 


Ser Cys Xaa Arg Arg Lys Xaa Asp Ser Ile Glu Lys Arg Phe Cys Phe 
                325                 330                 335     


Asp Val Glu Ala Val Asp Arg Pro Gly Val Ile Xaa Met Gln Ala Leu 
            340                 345                 350         


Ser Glu Glu Asp Arg Arg Leu Trp Met Glu Ala Met Asp Gly Arg Glu 
        355                 360                 365             


Pro Val Tyr Asn Ser Asn Lys Asp Ser Gln Ser Glu Gly Xaa Ala Gln 
    370                 375                 380                 


Leu Asp Ser Ile Gly Phe Ser Ile Ile Arg Lys Cys Ile His Ala Val 
385                 390                 395                 400 


Glu Xaa Arg Gly Ile Asn Glu Gln Gly Leu Tyr Arg Ile Val Gly Val 
                405                 410                 415     


Asn Ser Arg Val Gln Lys Leu Leu Ser Val Leu Met Asp Pro Lys Xaa 
            420                 425                 430         


Ala Ser Glu Xaa Glu Xaa Asp Ile Cys Ala Glu Trp Glu Ile Lys Xaa 
        435                 440                 445             


Ile Xaa Ser Ala Leu Lys Xaa Tyr Leu Arg Met Leu Pro Gly Pro Leu 
    450                 455                 460                 


Met Met Tyr Gln Phe Gln Arg Ser Phe Ile Lys Ala Ala Lys Leu Glu 
465                 470                 475                 480 


Asn Gln Glu Ser Arg Val Ser Glu Ile His Ser Leu Val His Arg Leu 
                485                 490                 495     


Pro Glu Lys Asn Arg Gln Met Leu Gln Leu Leu Met Asn His Leu Ala 
            500                 505                 510         


Asn Val Ala Asn Asn His Lys Gln Asn Leu Met Xaa Val Ala Asn Leu 
        515                 520                 525             


Gly Val Val Phe Gly Pro Xaa Leu Leu Arg Pro Gln Glu Glu Xaa Val 
    530                 535                 540                 


Ala Ala Ile Met Asp Ile Lys Phe Gln Asn Ile Val Ile Glu Ile Leu 
545                 550                 555                 560 


Ile Glu Asn His Glu Lys Ile Phe Asn Xaa Val Pro Asp Met Pro Leu 
                565                 570                 575     


Xaa Asn Ala Gln Leu His Leu Ser Arg Lys Lys Ser Ser Asp Ser Lys 
            580                 585                 590         


Pro Pro Ser Cys Ser Glu Arg Pro Leu Xaa Leu Phe His Xaa Val Gln 
        595                 600                 605             


Ser Xaa Glu Lys Gln Glu Gln Arg Asn Ser Ile Ile Asn Ser Ser Leu 
    610                 615                 620                 


Glu Ser Val Ser Ser Asn Pro Asn Ser Ile Leu Asn Ser Ser Ser Ser 
625                 630                 635                 640 


Leu Gln Pro Asn Met Asn Ser Ser Asp Pro Asp Leu Ala Val Val Lys 
                645                 650                 655     


Pro Xaa Arg Pro Asn Ser Leu Pro Pro Asn Pro Ser Pro Xaa Ser Pro 
            660                 665                 670         


Leu Ser Pro Ser Trp Pro Met Phe Ser Ala Pro Ser Ser Pro Met Pro 
        675                 680                 685             


Xaa Ser Ser Xaa Ser Ser Asp Ser Ser Pro Val Arg Ser Val Ala Gly 
    690                 695                 700                 


Phe Val Trp Phe Ser Val Ala Ala Val Val Leu Ser Leu Ala Arg Ser 
705                 710                 715                 720 


Ser Leu His Ala Val Phe Ser Leu Leu Val Asn Phe Val Pro Cys His 
                725                 730                 735     


Pro Asn Leu His Leu Leu Phe Asp Arg Pro Glu Glu Ala Val His Glu 
            740                 745                 750         


Asp Ser Ser Xaa Pro Phe Arg Lys Ala Lys Ala Leu Tyr Ala Cys Lys 
        755                 760                 765             


Ala Glu His Asp Ser Glu Leu Ser Phe Xaa Ala Gly Xaa Val Phe Asp 
    770                 775                 780                 


Asn Val His Pro Ser Gln Glu Pro Gly Trp Leu Glu Gly Xaa Leu Asn 
785                 790                 795                 800 


Gly Lys Xaa Gly Leu Ile Pro Glu Asn Tyr Val Glu Phe Leu 
                805                 810                 


<210> 2795
<211> 91
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<400> 2795
Met Val Pro Phe Asp Gln Lys Ser Gly Gly Lys Gly Gly Glu Asp Glu 
1               5                   10                  15      


Ser Val Ile Leu Lys Ser Cys Xaa Arg Arg Lys Xaa Asp Ser Ile Glu 
            20                  25                  30          


Lys Arg Phe Cys Phe Asp Val Glu Ala Val Asp Arg Pro Gly Val Ile 
        35                  40                  45              


Xaa Met Gln Ala Leu Ser Glu Glu Asp Arg Arg Leu Trp Met Glu Ala 
    50                  55                  60                  


Met Asp Gly Arg Glu Pro Val Tyr Asn Ser Asn Lys Asp Ser Gln Ser 
65                  70                  75                  80  


Glu Gly Xaa Ala Gln Leu Asp Ser Ile Gly Phe 
                85                  90      


<210> 2796
<211> 127
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<400> 2796
Val Ile Glu Ile Leu Ile Glu Asn His Glu Lys Ile Phe Asn Xaa Val 
1               5                   10                  15      


Pro Asp Met Pro Leu Xaa Asn Ala Gln Leu His Leu Ser Arg Lys Lys 
            20                  25                  30          


Ser Ser Asp Ser Lys Pro Pro Ser Cys Ser Glu Arg Pro Leu Xaa Leu 
        35                  40                  45              


Phe His Xaa Val Gln Ser Xaa Glu Lys Gln Glu Gln Arg Asn Ser Ile 
    50                  55                  60                  


Ile Asn Ser Ser Leu Glu Ser Val Ser Ser Asn Pro Asn Ser Ile Leu 
65                  70                  75                  80  


Asn Ser Ser Ser Ser Leu Gln Pro Asn Met Asn Ser Ser Asp Pro Asp 
                85                  90                  95      


Leu Ala Val Val Lys Pro Xaa Arg Pro Asn Ser Leu His Trp Gly Phe 
            100                 105                 110         


Gly Met Cys Leu Glu Gly Cys Xaa Glu Val Gln Ser Pro Ala Ser 
        115                 120                 125         


<210> 2797
<211> 388
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<400> 2797
Xaa Ala Gln Leu Asp Ser Ile Gly Phe Ser Ile Ile Arg Lys Cys Ile 
1               5                   10                  15      


His Ala Val Glu Xaa Arg Gly Ile Asn Glu Gln Gly Leu Tyr Arg Ile 
            20                  25                  30          


Val Gly Val Asn Ser Arg Val Gln Lys Leu Leu Ser Val Leu Met Asp 
        35                  40                  45              


Pro Lys Xaa Ala Ser Glu Xaa Glu Xaa Asp Ile Cys Ala Glu Trp Glu 
    50                  55                  60                  


Ile Lys Xaa Ile Xaa Ser Ala Leu Lys Xaa Tyr Leu Arg Met Leu Pro 
65                  70                  75                  80  


Gly Pro Leu Met Met Tyr Gln Phe Gln Arg Ser Phe Ile Lys Ala Ala 
                85                  90                  95      


Lys Leu Glu Asn Gln Glu Ser Arg Val Ser Glu Ile His Ser Leu Val 
            100                 105                 110         


His Arg Leu Pro Glu Lys Asn Arg Gln Met Leu Gln Leu Leu Met Asn 
        115                 120                 125             


His Leu Ala Asn Val Ala Asn Asn His Lys Gln Asn Leu Met Xaa Val 
    130                 135                 140                 


Ala Asn Leu Gly Val Val Phe Gly Pro Xaa Leu Leu Arg Pro Gln Glu 
145                 150                 155                 160 


Glu Xaa Val Ala Ala Ile Met Asp Ile Lys Phe Gln Asn Ile Val Ile 
                165                 170                 175     


Glu Ile Leu Ile Glu Asn His Glu Lys Ile Phe Asn Xaa Val Pro Asp 
            180                 185                 190         


Met Pro Leu Xaa Asn Ala Gln Leu His Leu Ser Arg Lys Lys Ser Ser 
        195                 200                 205             


Asp Ser Lys Pro Pro Ser Cys Ser Glu Arg Pro Leu Xaa Leu Phe His 
    210                 215                 220                 


Xaa Val Gln Ser Xaa Glu Lys Gln Glu Gln Arg Asn Ser Ile Ile Asn 
225                 230                 235                 240 


Ser Ser Leu Glu Ser Val Ser Ser Asn Pro Asn Ser Ile Leu Asn Ser 
                245                 250                 255     


Ser Ser Ser Leu Gln Pro Asn Met Asn Ser Ser Asp Pro Asp Leu Ala 
            260                 265                 270         


Val Val Lys Pro Xaa Arg Pro Asn Ser Leu Pro Pro Asn Pro Ser Pro 
        275                 280                 285             


Xaa Ser Pro Leu Ser Pro Ser Trp Pro Met Phe Ser Ala Pro Ser Ser 
    290                 295                 300                 


Pro Met Pro Xaa Ser Ser Xaa Ser Ser Asp Ser Ser Pro Val Arg Pro 
305                 310                 315                 320 


Glu Glu Ala Val His Glu Asp Ser Ser Xaa Pro Phe Arg Lys Ala Lys 
                325                 330                 335     


Ala Leu Tyr Ala Cys Lys Ala Glu His Asp Ser Glu Leu Ser Phe Xaa 
            340                 345                 350         


Ala Gly Xaa Val Phe Asp Asn Val His Pro Ser Gln Glu Pro Gly Trp 
        355                 360                 365             


Leu Glu Gly Xaa Leu Asn Gly Lys Xaa Gly Leu Ile Pro Glu Asn Tyr 
    370                 375                 380                 


Val Glu Phe Leu 
385             


<210> 2798
<211> 294
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<400> 2798
Xaa Pro Lys Xaa Ala Ser Glu Xaa Glu Xaa Asp Ile Cys Ala Glu Trp 
1               5                   10                  15      


Glu Ile Lys Xaa Ile Xaa Ser Ala Leu Lys Xaa Tyr Leu Arg Met Leu 
            20                  25                  30          


Pro Gly Pro Leu Met Met Tyr Gln Phe Gln Arg Ser Phe Ile Lys Ala 
        35                  40                  45              


Ala Lys Leu Glu Asn Gln Glu Ser Arg Val Ser Glu Ile His Ser Leu 
    50                  55                  60                  


Val His Arg Leu Pro Glu Lys Asn Arg Gln Met Leu Gln Leu Leu Met 
65                  70                  75                  80  


Asn His Leu Ala Asn Val Ala Asn Asn His Lys Gln Asn Leu Met Xaa 
                85                  90                  95      


Val Ala Asn Leu Gly Val Val Phe Gly Pro Xaa Leu Leu Arg Pro Gln 
            100                 105                 110         


Glu Glu Xaa Val Ala Ala Ile Met Asp Ile Lys Phe Gln Asn Ile Val 
        115                 120                 125             


Ile Glu Ile Leu Ile Glu Asn His Glu Lys Ile Phe Asn Xaa Val Pro 
    130                 135                 140                 


Asp Met Pro Leu Xaa Asn Ala Gln Leu His Leu Ser Arg Lys Lys Ser 
145                 150                 155                 160 


Ser Asp Ser Lys Pro Pro Ser Cys Ser Glu Arg Pro Leu Xaa Leu Phe 
                165                 170                 175     


His Xaa Val Gln Ser Xaa Glu Lys Gln Glu Gln Arg Asn Ser Ile Ile 
            180                 185                 190         


Asn Ser Ser Leu Glu Ser Val Ser Ser Asn Pro Asn Ser Ile Leu Asn 
        195                 200                 205             


Ser Ser Ser Ser Leu Gln Pro Asn Met Asn Ser Ser Asp Pro Asp Leu 
    210                 215                 220                 


Ala Val Val Lys Pro Xaa Arg Pro Asn Ser Leu Xaa Pro Phe Arg Lys 
225                 230                 235                 240 


Ala Lys Ala Leu Tyr Ala Cys Lys Ala Glu His Asp Ser Glu Leu Ser 
                245                 250                 255     


Phe Xaa Ala Gly Xaa Val Phe Asp Asn Val His Pro Ser Gln Glu Pro 
            260                 265                 270         


Gly Trp Leu Glu Gly Xaa Leu Asn Gly Lys Xaa Gly Leu Ile Pro Glu 
        275                 280                 285             


Asn Tyr Val Glu Phe Leu 
    290                 


<210> 2799
<211> 98
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<400> 2799
Xaa Pro Asn Pro Ser Pro Xaa Ser Pro Leu Ser Pro Ser Trp Pro Met 
1               5                   10                  15      


Phe Ser Ala Pro Ser Ser Pro Met Pro Xaa Ser Ser Xaa Ser Ser Asp 
            20                  25                  30          


Ser Ser Pro Val Ser Xaa Pro Phe Arg Lys Ala Lys Ala Leu Tyr Ala 
        35                  40                  45              


Cys Lys Ala Glu His Asp Ser Glu Leu Ser Phe Xaa Ala Gly Xaa Val 
    50                  55                  60                  


Phe Asp Asn Ala Glu Cys Pro Ser Ala Ser Xaa Ala Ile Phe Xaa Ala 
65                  70                  75                  80  


Xaa Pro Lys Leu Arg Ala Pro Pro Pro Leu Xaa Trp Ala Leu Pro Leu 
                85                  90                  95      


Ala Ala 
        


<210> 2800
<211> 154
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<400> 2800
Xaa Pro Pro Asn Pro Ser Pro Xaa Ser Pro Leu Ser Pro Ser Trp Pro 
1               5                   10                  15      


Met Phe Ser Ala Pro Ser Ser Pro Met Pro Xaa Ser Ser Xaa Ser Ser 
            20                  25                  30          


Asp Ser Ser Pro Val Arg Ser Val Ala Gly Phe Val Trp Phe Ser Val 
        35                  40                  45              


Ala Ala Val Val Leu Ser Leu Ala Arg Ser Ser Leu His Ala Val Phe 
    50                  55                  60                  


Ser Leu Leu Val Asn Phe Val Pro Cys His Pro Asn Leu His Leu Leu 
65                  70                  75                  80  


Phe Asp Arg Pro Glu Glu Ala Val His Glu Asp Ser Ser Xaa Pro Phe 
                85                  90                  95      


Arg Lys Ala Lys Ala Leu Tyr Ala Cys Lys Ala Glu His Asp Ser Glu 
            100                 105                 110         


Leu Ser Phe Xaa Ala Gly Xaa Val Phe Asp Asn Ala Glu Cys Pro Ser 
        115                 120                 125             


Ala Ser Xaa Ala Ile Phe Xaa Ala Xaa Pro Lys Leu Arg Ala Pro Pro 
    130                 135                 140                 


Pro Leu Xaa Trp Ala Leu Pro Leu Ala Ala 
145                 150                 


<210> 2801
<211> 867
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<400> 2801
Met Ala Ala Asp Val Val Gly Asp Val Tyr Val Leu Val Glu His Pro 
1               5                   10                  15      


Phe Glu Tyr Xaa Gly Lys Asp Gly Arg Arg Val Ala Ile Arg Pro Asn 
            20                  25                  30          


Glu Arg Tyr Arg Leu Leu Arg Arg Ser Xaa Glu His Trp Trp His Val 
        35                  40                  45              


Arg Arg Glu Pro Gly Gly Arg Pro Phe Tyr Leu Pro Ala Gln Tyr Val 
    50                  55                  60                  


Arg Glu Leu Pro Ala Leu Gly Asn Pro Ala Ala Ala Ala Pro Pro Gly 
65                  70                  75                  80  


Pro His Pro Ser Pro Ala Ala Pro Glu Pro Leu Ala Tyr Asp Tyr Arg 
                85                  90                  95      


Phe Val Ser Ala Ala Ala Xaa Ala Gly Pro Asp Gly Ala Pro Glu Glu 
            100                 105                 110         


Ser Gly Gly Arg Ala Ser Ser Leu Cys Gly Pro Ala Gln Arg Gly Ala 
        115                 120                 125             


Ala Xaa Gln Arg Ser Ser Leu Ala Pro Gly Leu Pro Ala Cys Leu Tyr 
    130                 135                 140                 


Leu Arg Pro Ala Ala Pro Val Arg Pro Ala Gln Ser Leu Asn Asp Leu 
145                 150                 155                 160 


Ala Cys Ala Ala Val Ser Pro Pro Ala Gly Leu Leu Gly Ser Ser Gly 
                165                 170                 175     


Ser Phe Lys Ala Cys Ser Val Ala Gly Ser Trp Val Cys Pro Arg Pro 
            180                 185                 190         


Leu Ala Arg Ser Asp Ser Glu Asn Val Tyr Glu Val Ile Gln Asp Leu 
        195                 200                 205             


His Val Pro Pro Pro Glu Glu Ser Ala Glu Gln Val Asp Asp Pro Pro 
    210                 215                 220                 


Glu Pro Val Tyr Ala Asn Ile Glu Arg Gln Pro Arg Ala Xaa Ser Pro 
225                 230                 235                 240 


Gly Ala Ala Ala Ala Pro Leu Pro Ser Pro Val Trp Glu Xaa His Xaa 
                245                 250                 255     


Asp Ala Gly Xaa Gly Arg Pro Tyr Tyr Tyr Asn Pro Asp Xaa Gly Val 
            260                 265                 270         


Xaa Xaa Trp Glu Ser Pro Phe Glu Ala Ala Glu Gly Ala Ala Ser Pro 
        275                 280                 285             


Ala Xaa Ser Pro Ala Ser Val Asp Ser His Val Ser Leu Glu Xaa Glu 
    290                 295                 300                 


Trp Gly Gln Tyr Trp Asp Glu Glu Ser Arg Arg Val Phe Phe Tyr Asn 
305                 310                 315                 320 


Pro Leu Xaa Gly Glu Xaa Ala Trp Glu Asp Glu Ala Glu Asn Glu Pro 
                325                 330                 335     


Glu Glu Glu Leu Glu Met Gln Pro Gly Leu Ser Pro Gly Ser Pro Gly 
            340                 345                 350         


Asp Pro Arg Pro Pro Xaa Pro Glu Xaa Asp Tyr Pro Glu Ser Leu Xaa 
        355                 360                 365             


Ser Tyr Pro Glu Glu Asp Tyr Ser Pro Val Gly Ser Phe Gly Glu Pro 
    370                 375                 380                 


Gly Pro Xaa Ser Pro Leu Xaa Xaa Pro Pro Gly Trp Ser Cys His Val 
385                 390                 395                 400 


Ser Gln Asp Lys Gln Met Leu Tyr Xaa Asn His Phe Xaa Gln Glu Gln 
                405                 410                 415     


Trp Val Arg Leu Glu Asp Pro His Gly Lys Pro Tyr Phe Tyr Asn Pro 
            420                 425                 430         


Glu Asp Ser Ser Val Arg Trp Glu Leu Pro Gln Val Pro Val Pro Ala 
        435                 440                 445             


Pro Arg Ser Ile His Lys Ser Ser Gln Asp Gly Asp Xaa Pro Ala Gln 
    450                 455                 460                 


Ala Ser Pro Pro Glu Glu Lys Xaa Lys Xaa Leu Asp Lys Ala Gly Val 
465                 470                 475                 480 


Leu His Arg Xaa Lys Xaa Ala Asp Lys Gly Lys Arg Leu Arg Lys Lys 
                485                 490                 495     


His Trp Ser Ala Ser Trp Xaa Val Leu Glu Gly Gly Val Leu Xaa Phe 
            500                 505                 510         


Phe Lys Asp Ser Lys Xaa Ser Ala Ala Gly Gly Leu Arg Gln Pro Ser 
        515                 520                 525             


Lys Phe Ser Xaa Pro Glu Tyr Xaa Val Glu Leu Arg Gly Ala Xaa Leu 
    530                 535                 540                 


Ser Trp Ala Pro Lys Asp Lys Ser Ser Arg Lys Asn Val Leu Glu Leu 
545                 550                 555                 560 


Arg Ser Arg Asp Gly Ser Glu Tyr Leu Ile Gln His Asp Ser Glu Ala 
                565                 570                 575     


Ile Ile Ser Xaa Trp His Lys Ala Ile Ala Gln Gly Ile Gln Glu Leu 
            580                 585                 590         


Ser Ala Glu Leu Pro Pro Glu Glu Ser Glu Ser Ser Arg Val Asp Phe 
        595                 600                 605             


Gly Ser Ser Glu Arg Leu Gly Ser Trp Gln Glu Lys Glu Glu Asp Ala 
    610                 615                 620                 


Arg Pro Asn Ala Ala Ala Pro Ala Leu Gly Pro Val Gly Leu Glu Ser 
625                 630                 635                 640 


Asp Leu Ser Lys Val Arg His Lys Leu Arg Lys Phe Leu Gln Arg Arg 
                645                 650                 655     


Pro Xaa Leu Gln Ser Leu Arg Glu Lys Gly Tyr Ile Lys Asp Gln Val 
            660                 665                 670         


Phe Gly Cys Ala Leu Ala Ala Leu Cys Glu Arg Glu Arg Ser Arg Val 
        675                 680                 685             


Pro Arg Phe Val Gln Gln Cys Ile Arg Ala Val Glu Ala Arg Gly Leu 
    690                 695                 700                 


Asp Ile Asp Gly Leu Tyr Arg Ile Ser Gly Asn Leu Ala Xaa Ile Gln 
705                 710                 715                 720 


Lys Leu Arg Tyr Lys Val Asp His Asp Glu Arg Leu Asp Leu Asp Asp 
                725                 730                 735     


Gly Arg Trp Glu Asp Val His Val Ile Xaa Gly Ala Leu Lys Leu Phe 
            740                 745                 750         


Phe Arg Glu Leu Pro Glu Pro Leu Phe Pro Phe Ser His Phe Arg Gln 
        755                 760                 765             


Phe Ile Ala Ala Ile Lys Leu Gln Asp Gln Ala Arg Arg Ser Arg Cys 
    770                 775                 780                 


Val Arg Asp Leu Val Arg Ser Leu Pro Ala Pro Asn His Asp Xaa Leu 
785                 790                 795                 800 


Arg Met Leu Phe Gln His Leu Cys Arg Val Ile Glu His Gly Glu Gln 
                805                 810                 815     


Asn Arg Met Ser Val Gln Ser Val Ala Ile Val Phe Gly Pro Xaa Leu 
            820                 825                 830         


Leu Arg Pro Glu Val Glu Glu Xaa Ser Met Pro Met Xaa Met Val Phe 
        835                 840                 845             


Gln Asn Gln Val Val Glu Leu Ile Leu Gln Gln Cys Ala Asp Ile Phe 
    850                 855                 860                 


Pro Pro His 
865         


<210> 2802
<211> 889
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<400> 2802
Met Ala Ala Asp Val Val Gly Asp Val Tyr Val Leu Val Glu His Pro 
1               5                   10                  15      


Phe Glu Tyr Xaa Gly Lys Asp Gly Arg Arg Val Ala Ile Arg Pro Asn 
            20                  25                  30          


Glu Arg Tyr Arg Leu Leu Arg Arg Ser Xaa Glu His Trp Trp His Val 
        35                  40                  45              


Arg Arg Glu Pro Gly Gly Arg Pro Phe Tyr Leu Pro Ala Gln Tyr Val 
    50                  55                  60                  


Arg Glu Leu Pro Ala Leu Gly Asn Pro Ala Ala Ala Ala Pro Pro Gly 
65                  70                  75                  80  


Pro His Pro Ser Pro Ala Ala Pro Glu Pro Leu Ala Tyr Asp Tyr Arg 
                85                  90                  95      


Phe Val Ser Ala Ala Ala Xaa Ala Gly Pro Asp Gly Ala Pro Glu Glu 
            100                 105                 110         


Ser Gly Gly Arg Ala Ser Ser Leu Cys Gly Pro Ala Gln Arg Gly Ala 
        115                 120                 125             


Ala Xaa Gln Arg Ser Ser Leu Ala Pro Gly Leu Pro Ala Cys Leu Tyr 
    130                 135                 140                 


Leu Arg Pro Ala Ala Pro Val Arg Pro Ala Gln Ser Leu Asn Asp Leu 
145                 150                 155                 160 


Ala Cys Ala Ala Val Ser Pro Pro Ala Gly Leu Leu Gly Ser Ser Gly 
                165                 170                 175     


Ser Phe Lys Ala Cys Ser Val Ala Gly Ser Trp Val Cys Pro Arg Pro 
            180                 185                 190         


Leu Ala Arg Ser Asp Ser Glu Asn Val Tyr Glu Val Ile Gln Asp Leu 
        195                 200                 205             


His Val Pro Pro Pro Glu Glu Ser Ala Glu Gln Val Asp Asp Pro Pro 
    210                 215                 220                 


Glu Pro Val Tyr Ala Asn Ile Glu Arg Gln Pro Arg Ala Xaa Ser Pro 
225                 230                 235                 240 


Gly Ala Ala Ala Ala Pro Leu Pro Ser Pro Val Trp Glu Xaa His Xaa 
                245                 250                 255     


Asp Ala Gly Xaa Gly Arg Pro Tyr Tyr Tyr Asn Pro Asp Xaa Gly Val 
            260                 265                 270         


Xaa Xaa Trp Glu Ser Pro Phe Glu Ala Ala Glu Gly Ala Ala Ser Pro 
        275                 280                 285             


Ala Xaa Ser Pro Ala Ser Val Asp Ser His Val Ser Leu Glu Xaa Glu 
    290                 295                 300                 


Trp Gly Gln Tyr Trp Asp Glu Glu Ser Arg Arg Val Phe Phe Tyr Asn 
305                 310                 315                 320 


Pro Leu Xaa Gly Glu Xaa Ala Trp Glu Asp Glu Ala Glu Asn Glu Pro 
                325                 330                 335     


Glu Glu Glu Leu Glu Met Gln Pro Gly Leu Ser Pro Gly Ser Pro Gly 
            340                 345                 350         


Asp Pro Arg Pro Pro Xaa Pro Glu Xaa Asp Tyr Pro Glu Ser Leu Xaa 
        355                 360                 365             


Ser Tyr Pro Glu Glu Asp Tyr Ser Pro Val Gly Ser Phe Gly Glu Pro 
    370                 375                 380                 


Gly Pro Xaa Ser Pro Leu Xaa Xaa Pro Pro Gly Trp Ser Cys His Val 
385                 390                 395                 400 


Ser Gln Asp Lys Gln Met Leu Tyr Xaa Asn His Phe Xaa Gln Glu Gln 
                405                 410                 415     


Trp Val Arg Leu Glu Asp Pro His Gly Lys Pro Tyr Phe Tyr Asn Pro 
            420                 425                 430         


Glu Asp Ser Ser Val Arg Trp Glu Leu Pro Gln Val Pro Val Pro Ala 
        435                 440                 445             


Pro Arg Ser Ile His Lys Ser Ser Gln Asp Gly Asp Xaa Pro Ala Gln 
    450                 455                 460                 


Ala Ser Pro Pro Glu Glu Lys Val Pro Ala Glu Leu Asp Glu Val Gly 
465                 470                 475                 480 


Ser Trp Glu Glu Val Ser Pro Ala Xaa Ala Ala Val Arg Xaa Lys Xaa 
                485                 490                 495     


Leu Asp Lys Ala Gly Val Leu His Arg Xaa Lys Xaa Ala Asp Lys Gly 
            500                 505                 510         


Lys Arg Leu Arg Lys Lys His Trp Ser Ala Ser Trp Xaa Val Leu Glu 
        515                 520                 525             


Gly Gly Val Leu Xaa Phe Phe Lys Asp Ser Lys Xaa Ser Ala Ala Gly 
    530                 535                 540                 


Gly Leu Arg Gln Pro Ser Lys Phe Ser Xaa Pro Glu Tyr Xaa Val Glu 
545                 550                 555                 560 


Leu Arg Gly Ala Xaa Leu Ser Trp Ala Pro Lys Asp Lys Ser Ser Arg 
                565                 570                 575     


Lys Asn Val Leu Glu Leu Arg Ser Arg Asp Gly Ser Glu Tyr Leu Ile 
            580                 585                 590         


Gln His Asp Ser Glu Ala Ile Ile Ser Xaa Trp His Lys Ala Ile Ala 
        595                 600                 605             


Gln Gly Ile Gln Glu Leu Ser Ala Glu Leu Pro Pro Glu Glu Ser Glu 
    610                 615                 620                 


Ser Ser Arg Val Asp Phe Gly Ser Ser Glu Arg Leu Gly Ser Trp Gln 
625                 630                 635                 640 


Glu Lys Glu Glu Asp Ala Arg Pro Asn Ala Ala Ala Pro Ala Leu Gly 
                645                 650                 655     


Pro Val Gly Leu Glu Ser Asp Leu Ser Lys Val Arg His Lys Leu Arg 
            660                 665                 670         


Lys Phe Leu Gln Arg Arg Pro Xaa Leu Gln Ser Leu Arg Glu Lys Gly 
        675                 680                 685             


Tyr Ile Lys Asp Gln Val Phe Gly Cys Ala Leu Ala Ala Leu Cys Glu 
    690                 695                 700                 


Arg Glu Arg Ser Arg Val Pro Arg Phe Val Gln Gln Cys Ile Arg Ala 
705                 710                 715                 720 


Val Glu Ala Arg Gly Leu Asp Ile Asp Gly Leu Tyr Arg Ile Ser Gly 
                725                 730                 735     


Asn Leu Ala Xaa Ile Gln Lys Leu Arg Tyr Lys Val Asp His Asp Glu 
            740                 745                 750         


Arg Leu Asp Leu Asp Asp Gly Arg Trp Glu Asp Val His Val Ile Xaa 
        755                 760                 765             


Gly Ala Leu Lys Leu Phe Phe Arg Glu Leu Pro Glu Pro Leu Phe Pro 
    770                 775                 780                 


Phe Ser His Phe Arg Gln Phe Ile Ala Ala Ile Lys Leu Gln Asp Gln 
785                 790                 795                 800 


Ala Arg Arg Ser Arg Cys Val Arg Asp Leu Val Arg Ser Leu Pro Ala 
                805                 810                 815     


Pro Asn His Asp Xaa Leu Arg Met Leu Phe Gln His Leu Cys Arg Val 
            820                 825                 830         


Ile Glu His Gly Glu Gln Asn Arg Met Ser Val Gln Ser Val Ala Ile 
        835                 840                 845             


Val Phe Gly Pro Xaa Leu Leu Arg Pro Glu Val Glu Glu Xaa Ser Met 
    850                 855                 860                 


Pro Met Xaa Met Val Phe Gln Asn Gln Val Val Glu Leu Ile Leu Gln 
865                 870                 875                 880 


Gln Cys Ala Asp Ile Phe Pro Pro His 
                885                 


<210> 2803
<211> 263
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<400> 2803
Met Ala Ala Asp Val Val Gly Asp Val Tyr Val Leu Val Glu His Pro 
1               5                   10                  15      


Phe Glu Tyr Xaa Gly Lys Asp Gly Arg Arg Val Ala Ile Arg Pro Asn 
            20                  25                  30          


Glu Arg Tyr Arg Leu Leu Arg Arg Ser Xaa Glu His Trp Trp His Val 
        35                  40                  45              


Arg Arg Glu Pro Gly Gly Arg Pro Phe Tyr Leu Pro Ala Gln Tyr Val 
    50                  55                  60                  


Arg Glu Leu Pro Ala Leu Gly Asn Pro Ala Ala Ala Ala Pro Pro Gly 
65                  70                  75                  80  


Pro His Pro Ser Pro Ala Ala Pro Glu Pro Leu Ala Tyr Asp Tyr Arg 
                85                  90                  95      


Phe Val Ser Ala Ala Ala Xaa Ala Gly Pro Asp Gly Ala Pro Glu Glu 
            100                 105                 110         


Ser Gly Gly Arg Ala Ser Ser Leu Cys Gly Pro Ala Gln Arg Gly Ala 
        115                 120                 125             


Ala Xaa Gln Arg Ser Ser Leu Ala Pro Gly Leu Pro Ala Cys Leu Tyr 
    130                 135                 140                 


Leu Arg Pro Ala Ala Pro Val Arg Pro Ala Gln Ser Leu Asn Asp Leu 
145                 150                 155                 160 


Ala Cys Ala Ala Val Ser Pro Pro Ala Gly Leu Leu Gly Ser Ser Gly 
                165                 170                 175     


Ser Phe Lys Ala Cys Ser Val Ala Gly Ser Trp Val Cys Pro Arg Pro 
            180                 185                 190         


Leu Ala Arg Ser Asp Ser Glu Asn Val Tyr Glu Val Ile Gln Asp Leu 
        195                 200                 205             


His Val Pro Pro Pro Glu Glu Ser Ala Glu Gln Val Pro Pro Arg Ala 
    210                 215                 220                 


Leu Gly Arg Gly Gly Gly Trp Arg Ala Arg Asp Arg Ala Arg Xaa Glu 
225                 230                 235                 240 


Pro Gly Arg Lys Glu Xaa Arg Ser Ala Gln Arg Arg Ala Arg Arg Pro 
                245                 250                 255     


Pro Leu Ser Glu Asp Phe Gly 
            260             


<210> 2804
<211> 867
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<400> 2804
Met Ala Ala Asp Val Val Gly Asp Val Tyr Val Leu Val Glu His Pro 
1               5                   10                  15      


Phe Glu Tyr Xaa Gly Lys Asp Gly Arg Arg Val Ala Ile Arg Pro Asn 
            20                  25                  30          


Glu Arg Tyr Arg Leu Leu Arg Arg Ser Xaa Glu His Trp Trp His Val 
        35                  40                  45              


Arg Arg Glu Pro Gly Gly Arg Pro Phe Tyr Leu Pro Ala Gln Tyr Val 
    50                  55                  60                  


Arg Glu Leu Pro Ala Leu Gly Asn Pro Ala Ala Ala Ala Pro Pro Gly 
65                  70                  75                  80  


Pro His Pro Ser Pro Ala Ala Pro Glu Pro Leu Ala Tyr Asp Tyr Arg 
                85                  90                  95      


Phe Val Ser Ala Ala Ala Xaa Ala Gly Pro Asp Gly Ala Pro Glu Glu 
            100                 105                 110         


Ser Gly Gly Arg Xaa Ser Ser Leu Cys Gly Pro Ala Gln Arg Gly Ala 
        115                 120                 125             


Ala Xaa Gln Arg Ser Ser Leu Ala Pro Gly Leu Pro Ala Cys Leu Tyr 
    130                 135                 140                 


Leu Arg Pro Ala Ala Pro Val Arg Pro Ala Gln Ser Leu Asn Asp Leu 
145                 150                 155                 160 


Ala Cys Ala Ala Val Ser Pro Pro Ala Gly Leu Leu Gly Ser Ser Gly 
                165                 170                 175     


Ser Phe Lys Ala Cys Ser Val Ala Gly Ser Trp Val Cys Pro Arg Pro 
            180                 185                 190         


Leu Ala Arg Ser Asp Ser Glu Asn Val Tyr Glu Val Ile Gln Asp Leu 
        195                 200                 205             


His Val Pro Pro Arg Glu Glu Ser Ala Glu Gln Val Asp Asp Pro Pro 
    210                 215                 220                 


Glu Pro Val Tyr Ala Asn Ile Glu Arg Gln Pro Arg Ala Xaa Ser Pro 
225                 230                 235                 240 


Gly Ala Ala Ala Ala Pro Leu Pro Ser Pro Val Trp Glu Xaa His Xaa 
                245                 250                 255     


Asp Ala Gly Xaa Gly Arg Pro Tyr Tyr Tyr Asn Pro Asp Xaa Gly Val 
            260                 265                 270         


Xaa Xaa Trp Glu Ser Pro Phe Glu Ala Ala Glu Gly Ala Ala Ser Pro 
        275                 280                 285             


Ala Xaa Ser Pro Ala Ser Val Asp Ser His Val Ser Leu Glu Xaa Glu 
    290                 295                 300                 


Trp Gly Gln Tyr Trp Asp Glu Glu Ser Arg Arg Val Phe Phe Tyr Asn 
305                 310                 315                 320 


Pro Leu Xaa Gly Glu Xaa Ala Trp Glu Asp Glu Ala Glu Asn Glu Pro 
                325                 330                 335     


Glu Glu Glu Leu Glu Met Gln Pro Gly Leu Ser Pro Gly Ser Pro Gly 
            340                 345                 350         


Asp Pro Arg Pro Pro Xaa Pro Glu Xaa Asp Tyr Pro Glu Ser Leu Xaa 
        355                 360                 365             


Ser Tyr Pro Glu Glu Asp Tyr Ser Pro Val Gly Ser Phe Gly Glu Pro 
    370                 375                 380                 


Gly Pro Xaa Ser Pro Leu Xaa Xaa Pro Pro Gly Trp Ser Cys His Val 
385                 390                 395                 400 


Ser Gln Asp Lys Gln Met Leu Tyr Xaa Asn His Phe Xaa Gln Glu Gln 
                405                 410                 415     


Trp Val Arg Leu Glu Asp Pro His Gly Lys Pro Tyr Phe Tyr Asn Pro 
            420                 425                 430         


Glu Asp Ser Ser Val Arg Trp Glu Leu Pro Gln Val Pro Val Pro Ala 
        435                 440                 445             


Pro Arg Ser Ile His Lys Ser Ser Gln Asp Gly Asp Xaa Pro Ala Gln 
    450                 455                 460                 


Ala Ser Pro Pro Glu Glu Lys Xaa Lys Xaa Leu Asp Lys Ala Gly Val 
465                 470                 475                 480 


Leu His Arg Xaa Lys Xaa Ala Asp Lys Gly Lys Arg Leu Arg Lys Lys 
                485                 490                 495     


His Trp Ser Ala Ser Trp Xaa Val Leu Glu Gly Gly Val Leu Xaa Phe 
            500                 505                 510         


Phe Lys Asp Ser Lys Xaa Ser Ala Ala Gly Gly Leu Arg Gln Pro Ser 
        515                 520                 525             


Lys Phe Ser Xaa Pro Glu Tyr Xaa Val Glu Leu Arg Gly Ala Xaa Leu 
    530                 535                 540                 


Ser Trp Ala Pro Lys Asp Lys Ser Ser Arg Lys Asn Val Leu Glu Leu 
545                 550                 555                 560 


Arg Ser Arg Asp Gly Ser Glu Tyr Leu Ile Gln His Asp Ser Glu Ala 
                565                 570                 575     


Ile Ile Ser Xaa Trp His Lys Ala Ile Ala Gln Gly Ile Gln Glu Leu 
            580                 585                 590         


Ser Ala Glu Leu Pro Pro Glu Glu Ser Glu Ser Ser Arg Val Asp Phe 
        595                 600                 605             


Gly Ser Ser Glu Arg Leu Gly Ser Trp Gln Glu Lys Glu Glu Asp Ala 
    610                 615                 620                 


Arg Pro Asn Ala Ala Ala Pro Ala Leu Gly Pro Val Gly Leu Glu Ser 
625                 630                 635                 640 


Asp Leu Ser Lys Val Arg His Lys Leu Arg Lys Phe Leu Gln Arg Arg 
                645                 650                 655     


Pro Xaa Leu Gln Ser Leu Arg Glu Lys Gly Tyr Ile Lys Asp Gln Val 
            660                 665                 670         


Phe Gly Cys Ala Leu Ala Ala Leu Cys Glu Arg Glu Arg Ser Arg Val 
        675                 680                 685             


Pro Arg Phe Val Gln Gln Cys Ile Arg Ala Val Glu Ala Arg Gly Leu 
    690                 695                 700                 


Asp Ile Asp Gly Leu Tyr Arg Ile Ser Gly Asn Leu Ala Xaa Ile Gln 
705                 710                 715                 720 


Lys Leu Arg Tyr Lys Val Asp His Asp Glu Arg Leu Asp Leu Asp Asp 
                725                 730                 735     


Gly Arg Trp Glu Asp Val His Val Ile Xaa Gly Ala Leu Lys Leu Phe 
            740                 745                 750         


Phe Arg Glu Leu Pro Glu Pro Leu Phe Pro Phe Ser His Phe Arg Gln 
        755                 760                 765             


Phe Ile Ala Ala Ile Lys Leu Gln Asp Gln Ala Arg Arg Ser Arg Cys 
    770                 775                 780                 


Val Arg Asp Leu Val Arg Ser Leu Pro Ala Pro Asn His Asp Xaa Leu 
785                 790                 795                 800 


Arg Met Leu Phe Gln His Leu Cys Arg Val Ile Glu His Gly Glu Gln 
                805                 810                 815     


Asn Arg Met Ser Val Gln Ser Val Ala Ile Val Phe Gly Pro Xaa Leu 
            820                 825                 830         


Leu Arg Pro Glu Val Glu Glu Xaa Ser Met Pro Met Xaa Met Val Phe 
        835                 840                 845             


Gln Asn Gln Val Val Glu Leu Ile Leu Gln Gln Cys Ala Asp Ile Phe 
    850                 855                 860                 


Pro Pro His 
865         


<210> 2805
<211> 889
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<400> 2805
Met Ala Ala Asp Val Val Gly Asp Val Tyr Val Leu Val Glu His Pro 
1               5                   10                  15      


Phe Glu Tyr Xaa Gly Lys Asp Gly Arg Arg Val Ala Ile Arg Pro Asn 
            20                  25                  30          


Glu Arg Tyr Arg Leu Leu Arg Arg Ser Xaa Glu His Trp Trp His Val 
        35                  40                  45              


Arg Arg Glu Pro Gly Gly Arg Pro Phe Tyr Leu Pro Ala Gln Tyr Val 
    50                  55                  60                  


Arg Glu Leu Pro Ala Leu Gly Asn Pro Ala Ala Ala Ala Pro Pro Gly 
65                  70                  75                  80  


Pro His Pro Ser Pro Ala Ala Pro Glu Pro Leu Ala Tyr Asp Tyr Arg 
                85                  90                  95      


Phe Val Ser Ala Ala Ala Xaa Ala Gly Pro Asp Gly Ala Pro Glu Glu 
            100                 105                 110         


Ser Gly Gly Arg Xaa Ser Ser Leu Cys Gly Pro Ala Gln Arg Gly Ala 
        115                 120                 125             


Ala Xaa Gln Arg Ser Ser Leu Ala Pro Gly Leu Pro Ala Cys Leu Tyr 
    130                 135                 140                 


Leu Arg Pro Ala Ala Pro Val Arg Pro Ala Gln Ser Leu Asn Asp Leu 
145                 150                 155                 160 


Ala Cys Ala Ala Val Ser Pro Pro Ala Gly Leu Leu Gly Ser Ser Gly 
                165                 170                 175     


Ser Phe Lys Ala Cys Ser Val Ala Gly Ser Trp Val Cys Pro Arg Pro 
            180                 185                 190         


Leu Ala Arg Ser Asp Ser Glu Asn Val Tyr Glu Val Ile Gln Asp Leu 
        195                 200                 205             


His Val Pro Pro Arg Glu Glu Ser Ala Glu Gln Val Asp Asp Pro Pro 
    210                 215                 220                 


Glu Pro Val Tyr Ala Asn Ile Glu Arg Gln Pro Arg Ala Xaa Ser Pro 
225                 230                 235                 240 


Gly Ala Ala Ala Ala Pro Leu Pro Ser Pro Val Trp Glu Xaa His Xaa 
                245                 250                 255     


Asp Ala Gly Xaa Gly Arg Pro Tyr Tyr Tyr Asn Pro Asp Xaa Gly Val 
            260                 265                 270         


Xaa Xaa Trp Glu Ser Pro Phe Glu Ala Ala Glu Gly Ala Ala Ser Pro 
        275                 280                 285             


Ala Xaa Ser Pro Ala Ser Val Asp Ser His Val Ser Leu Glu Xaa Glu 
    290                 295                 300                 


Trp Gly Gln Tyr Trp Asp Glu Glu Ser Arg Arg Val Phe Phe Tyr Asn 
305                 310                 315                 320 


Pro Leu Xaa Gly Glu Xaa Ala Trp Glu Asp Glu Ala Glu Asn Glu Pro 
                325                 330                 335     


Glu Glu Glu Leu Glu Met Gln Pro Gly Leu Ser Pro Gly Ser Pro Gly 
            340                 345                 350         


Asp Pro Arg Pro Pro Xaa Pro Glu Xaa Asp Tyr Pro Glu Ser Leu Xaa 
        355                 360                 365             


Ser Tyr Pro Glu Glu Asp Tyr Ser Pro Val Gly Ser Phe Gly Glu Pro 
    370                 375                 380                 


Gly Pro Xaa Ser Pro Leu Xaa Xaa Pro Pro Gly Trp Ser Cys His Val 
385                 390                 395                 400 


Ser Gln Asp Lys Gln Met Leu Tyr Xaa Asn His Phe Xaa Gln Glu Gln 
                405                 410                 415     


Trp Val Arg Leu Glu Asp Pro His Gly Lys Pro Tyr Phe Tyr Asn Pro 
            420                 425                 430         


Glu Asp Ser Ser Val Arg Trp Glu Leu Pro Gln Val Pro Val Pro Ala 
        435                 440                 445             


Pro Arg Ser Ile His Lys Ser Ser Gln Asp Gly Asp Xaa Pro Ala Gln 
    450                 455                 460                 


Ala Ser Pro Pro Glu Glu Lys Val Pro Ala Glu Leu Asp Glu Val Gly 
465                 470                 475                 480 


Ser Trp Glu Glu Val Ser Pro Ala Xaa Ala Ala Val Arg Xaa Lys Xaa 
                485                 490                 495     


Leu Asp Lys Ala Gly Val Leu His Arg Xaa Lys Xaa Ala Asp Lys Gly 
            500                 505                 510         


Lys Arg Leu Arg Lys Lys His Trp Ser Ala Ser Trp Xaa Val Leu Glu 
        515                 520                 525             


Gly Gly Val Leu Xaa Phe Phe Lys Asp Ser Lys Xaa Ser Ala Ala Gly 
    530                 535                 540                 


Gly Leu Arg Gln Pro Ser Lys Phe Ser Xaa Pro Glu Tyr Xaa Val Glu 
545                 550                 555                 560 


Leu Arg Gly Ala Xaa Leu Ser Trp Ala Pro Lys Asp Lys Ser Ser Arg 
                565                 570                 575     


Lys Asn Val Leu Glu Leu Arg Ser Arg Asp Gly Ser Glu Tyr Leu Ile 
            580                 585                 590         


Gln His Asp Ser Glu Ala Ile Ile Ser Xaa Trp His Lys Ala Ile Ala 
        595                 600                 605             


Gln Gly Ile Gln Glu Leu Ser Ala Glu Leu Pro Pro Glu Glu Ser Glu 
    610                 615                 620                 


Ser Ser Arg Val Asp Phe Gly Ser Ser Glu Arg Leu Gly Ser Trp Gln 
625                 630                 635                 640 


Glu Lys Glu Glu Asp Ala Arg Pro Asn Ala Ala Ala Pro Ala Leu Gly 
                645                 650                 655     


Pro Val Gly Leu Glu Ser Asp Leu Ser Lys Val Arg His Lys Leu Arg 
            660                 665                 670         


Lys Phe Leu Gln Arg Arg Pro Xaa Leu Gln Ser Leu Arg Glu Lys Gly 
        675                 680                 685             


Tyr Ile Lys Asp Gln Val Phe Gly Cys Ala Leu Ala Ala Leu Cys Glu 
    690                 695                 700                 


Arg Glu Arg Ser Arg Val Pro Arg Phe Val Gln Gln Cys Ile Arg Ala 
705                 710                 715                 720 


Val Glu Ala Arg Gly Leu Asp Ile Asp Gly Leu Tyr Arg Ile Ser Gly 
                725                 730                 735     


Asn Leu Ala Xaa Ile Gln Lys Leu Arg Tyr Lys Val Asp His Asp Glu 
            740                 745                 750         


Arg Leu Asp Leu Asp Asp Gly Arg Trp Glu Asp Val His Val Ile Xaa 
        755                 760                 765             


Gly Ala Leu Lys Leu Phe Phe Arg Glu Leu Pro Glu Pro Leu Phe Pro 
    770                 775                 780                 


Phe Ser His Phe Arg Gln Phe Ile Ala Ala Ile Lys Leu Gln Asp Gln 
785                 790                 795                 800 


Ala Arg Arg Ser Arg Cys Val Arg Asp Leu Val Arg Ser Leu Pro Ala 
                805                 810                 815     


Pro Asn His Asp Xaa Leu Arg Met Leu Phe Gln His Leu Cys Arg Val 
            820                 825                 830         


Ile Glu His Gly Glu Gln Asn Arg Met Ser Val Gln Ser Val Ala Ile 
        835                 840                 845             


Val Phe Gly Pro Xaa Leu Leu Arg Pro Glu Val Glu Glu Xaa Ser Met 
    850                 855                 860                 


Pro Met Xaa Met Val Phe Gln Asn Gln Val Val Glu Leu Ile Leu Gln 
865                 870                 875                 880 


Gln Cys Ala Asp Ile Phe Pro Pro His 
                885                 


<210> 2806
<211> 263
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<400> 2806
Met Ala Ala Asp Val Val Gly Asp Val Tyr Val Leu Val Glu His Pro 
1               5                   10                  15      


Phe Glu Tyr Xaa Gly Lys Asp Gly Arg Arg Val Ala Ile Arg Pro Asn 
            20                  25                  30          


Glu Arg Tyr Arg Leu Leu Arg Arg Ser Xaa Glu His Trp Trp His Val 
        35                  40                  45              


Arg Arg Glu Pro Gly Gly Arg Pro Phe Tyr Leu Pro Ala Gln Tyr Val 
    50                  55                  60                  


Arg Glu Leu Pro Ala Leu Gly Asn Pro Ala Ala Ala Ala Pro Pro Gly 
65                  70                  75                  80  


Pro His Pro Ser Pro Ala Ala Pro Glu Pro Leu Ala Tyr Asp Tyr Arg 
                85                  90                  95      


Phe Val Ser Ala Ala Ala Xaa Ala Gly Pro Asp Gly Ala Pro Glu Glu 
            100                 105                 110         


Ser Gly Gly Arg Xaa Ser Ser Leu Cys Gly Pro Ala Gln Arg Gly Ala 
        115                 120                 125             


Ala Xaa Gln Arg Ser Ser Leu Ala Pro Gly Leu Pro Ala Cys Leu Tyr 
    130                 135                 140                 


Leu Arg Pro Ala Ala Pro Val Arg Pro Ala Gln Ser Leu Asn Asp Leu 
145                 150                 155                 160 


Ala Cys Ala Ala Val Ser Pro Pro Ala Gly Leu Leu Gly Ser Ser Gly 
                165                 170                 175     


Ser Phe Lys Ala Cys Ser Val Ala Gly Ser Trp Val Cys Pro Arg Pro 
            180                 185                 190         


Leu Ala Arg Ser Asp Ser Glu Asn Val Tyr Glu Val Ile Gln Asp Leu 
        195                 200                 205             


His Val Pro Pro Arg Glu Glu Ser Ala Glu Gln Val Pro Pro Arg Ala 
    210                 215                 220                 


Leu Gly Arg Gly Gly Gly Trp Arg Ala Arg Asp Arg Ala Arg Xaa Glu 
225                 230                 235                 240 


Pro Gly Arg Lys Glu Xaa Arg Ser Ala Gln Arg Arg Ala Arg Arg Pro 
                245                 250                 255     


Pro Leu Ser Glu Asp Phe Gly 
            260             


<210> 2807
<211> 521
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<400> 2807
Met Gln Pro Gly Leu Ser Pro Gly Ser Pro Gly Asp Pro Arg Pro Pro 
1               5                   10                  15      


Xaa Pro Glu Xaa Asp Tyr Pro Glu Ser Leu Xaa Ser Tyr Pro Glu Glu 
            20                  25                  30          


Asp Tyr Ser Pro Val Gly Ser Phe Gly Glu Pro Gly Pro Xaa Ser Pro 
        35                  40                  45              


Leu Xaa Xaa Pro Pro Gly Trp Ser Cys His Val Ser Gln Asp Lys Gln 
    50                  55                  60                  


Met Leu Tyr Xaa Asn His Phe Xaa Gln Glu Gln Val Pro Val Pro Ala 
65                  70                  75                  80  


Pro Arg Ser Ile His Lys Ser Ser Gln Asp Gly Asp Xaa Pro Ala Gln 
                85                  90                  95      


Ala Ser Pro Pro Glu Glu Lys Val Pro Ala Glu Leu Asp Glu Val Gly 
            100                 105                 110         


Ser Trp Glu Glu Val Ser Pro Ala Xaa Ala Ala Val Arg Xaa Lys Xaa 
        115                 120                 125             


Leu Asp Lys Ala Gly Val Leu His Arg Xaa Lys Xaa Ala Asp Lys Gly 
    130                 135                 140                 


Lys Arg Leu Arg Lys Lys His Trp Ser Ala Ser Trp Xaa Val Leu Glu 
145                 150                 155                 160 


Gly Gly Val Leu Xaa Phe Phe Lys Asp Ser Lys Xaa Ser Ala Ala Gly 
                165                 170                 175     


Gly Leu Arg Gln Pro Ser Lys Phe Ser Xaa Pro Glu Tyr Xaa Val Glu 
            180                 185                 190         


Leu Arg Gly Ala Xaa Leu Ser Trp Ala Pro Lys Asp Lys Ser Ser Arg 
        195                 200                 205             


Lys Asn Val Leu Glu Leu Arg Ser Arg Asp Gly Ser Glu Tyr Leu Ile 
    210                 215                 220                 


Gln His Asp Ser Glu Ala Ile Ile Ser Xaa Trp His Lys Ala Ile Ala 
225                 230                 235                 240 


Gln Gly Ile Gln Glu Leu Ser Ala Glu Leu Pro Pro Glu Glu Ser Glu 
                245                 250                 255     


Ser Ser Arg Val Asp Phe Gly Ser Ser Glu Arg Leu Gly Ser Trp Gln 
            260                 265                 270         


Glu Lys Glu Glu Asp Ala Arg Pro Asn Ala Ala Ala Pro Ala Leu Gly 
        275                 280                 285             


Pro Val Gly Leu Glu Ser Asp Leu Ser Lys Val Arg His Lys Leu Arg 
    290                 295                 300                 


Lys Phe Leu Gln Arg Arg Pro Xaa Leu Gln Ser Leu Arg Glu Lys Gly 
305                 310                 315                 320 


Tyr Ile Lys Asp Gln Val Phe Gly Cys Ala Leu Ala Ala Leu Cys Glu 
                325                 330                 335     


Arg Glu Arg Ser Arg Val Pro Arg Phe Val Gln Gln Cys Ile Arg Ala 
            340                 345                 350         


Val Glu Ala Arg Gly Leu Asp Ile Asp Gly Leu Tyr Arg Ile Ser Gly 
        355                 360                 365             


Asn Leu Ala Xaa Ile Gln Lys Leu Arg Tyr Lys Val Asp His Asp Glu 
    370                 375                 380                 


Arg Leu Asp Leu Asp Asp Gly Arg Trp Glu Asp Val His Val Ile Xaa 
385                 390                 395                 400 


Gly Ala Leu Lys Leu Phe Phe Arg Glu Leu Pro Glu Pro Leu Phe Pro 
                405                 410                 415     


Phe Ser His Phe Arg Gln Phe Ile Ala Ala Ile Lys Leu Gln Asp Gln 
            420                 425                 430         


Ala Arg Arg Ser Arg Cys Val Arg Asp Leu Val Arg Ser Leu Pro Ala 
        435                 440                 445             


Pro Asn His Asp Xaa Leu Arg Met Leu Phe Gln His Leu Cys Arg Val 
    450                 455                 460                 


Ile Glu His Gly Glu Gln Asn Arg Met Ser Val Gln Ser Val Ala Ile 
465                 470                 475                 480 


Val Phe Gly Pro Xaa Leu Leu Arg Pro Glu Val Glu Glu Xaa Ser Met 
                485                 490                 495     


Pro Met Xaa Met Val Phe Gln Asn Gln Val Val Glu Leu Ile Leu Gln 
            500                 505                 510         


Gln Cys Ala Asp Ile Phe Pro Pro His 
        515                 520     


<210> 2808
<211> 548
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<400> 2808
Met Gln Pro Gly Leu Ser Pro Gly Ser Pro Gly Asp Pro Arg Pro Pro 
1               5                   10                  15      


Xaa Pro Glu Xaa Asp Tyr Pro Glu Ser Leu Xaa Ser Tyr Pro Glu Glu 
            20                  25                  30          


Asp Tyr Ser Pro Val Gly Ser Phe Gly Glu Pro Gly Pro Xaa Ser Pro 
        35                  40                  45              


Leu Xaa Xaa Pro Pro Gly Trp Ser Cys His Val Ser Gln Asp Lys Gln 
    50                  55                  60                  


Met Leu Tyr Xaa Asn His Phe Xaa Gln Glu Gln Trp Val Arg Leu Glu 
65                  70                  75                  80  


Asp Pro His Gly Lys Pro Tyr Phe Tyr Asn Pro Glu Asp Ser Ser Val 
                85                  90                  95      


Arg Trp Glu Leu Pro Gln Val Pro Val Pro Ala Pro Arg Ser Ile His 
            100                 105                 110         


Lys Ser Ser Gln Asp Gly Asp Xaa Pro Ala Gln Ala Ser Pro Pro Glu 
        115                 120                 125             


Glu Lys Val Pro Ala Glu Leu Asp Glu Val Gly Ser Trp Glu Glu Val 
    130                 135                 140                 


Ser Pro Ala Xaa Ala Ala Val Arg Xaa Lys Xaa Leu Asp Lys Ala Gly 
145                 150                 155                 160 


Val Leu His Arg Xaa Lys Xaa Ala Asp Lys Gly Lys Arg Leu Arg Lys 
                165                 170                 175     


Lys His Trp Ser Ala Ser Trp Xaa Val Leu Glu Gly Gly Val Leu Xaa 
            180                 185                 190         


Phe Phe Lys Asp Ser Lys Xaa Ser Ala Ala Gly Gly Leu Arg Gln Pro 
        195                 200                 205             


Ser Lys Phe Ser Xaa Pro Glu Tyr Xaa Val Glu Leu Arg Gly Ala Xaa 
    210                 215                 220                 


Leu Ser Trp Ala Pro Lys Asp Lys Ser Ser Arg Lys Asn Val Leu Glu 
225                 230                 235                 240 


Leu Arg Ser Arg Asp Gly Ser Glu Tyr Leu Ile Gln His Asp Ser Glu 
                245                 250                 255     


Ala Ile Ile Ser Xaa Trp His Lys Ala Ile Ala Gln Gly Ile Gln Glu 
            260                 265                 270         


Leu Ser Ala Glu Leu Pro Pro Glu Glu Ser Glu Ser Ser Arg Val Asp 
        275                 280                 285             


Phe Gly Ser Ser Glu Arg Leu Gly Ser Trp Gln Glu Lys Glu Glu Asp 
    290                 295                 300                 


Ala Arg Pro Asn Ala Ala Ala Pro Ala Leu Gly Pro Val Gly Leu Glu 
305                 310                 315                 320 


Ser Asp Leu Ser Lys Val Arg His Lys Leu Arg Lys Phe Leu Gln Arg 
                325                 330                 335     


Arg Pro Xaa Leu Gln Ser Leu Arg Glu Lys Gly Tyr Ile Lys Asp Gln 
            340                 345                 350         


Val Phe Gly Cys Ala Leu Ala Ala Leu Cys Glu Arg Glu Arg Ser Arg 
        355                 360                 365             


Val Pro Arg Phe Val Gln Gln Cys Ile Arg Ala Val Glu Ala Arg Gly 
    370                 375                 380                 


Leu Asp Ile Asp Gly Leu Tyr Arg Ile Ser Gly Asn Leu Ala Xaa Ile 
385                 390                 395                 400 


Gln Lys Leu Arg Tyr Lys Val Asp His Asp Glu Arg Leu Asp Leu Asp 
                405                 410                 415     


Asp Gly Arg Trp Glu Asp Val His Val Ile Xaa Gly Ala Leu Lys Leu 
            420                 425                 430         


Phe Phe Arg Glu Leu Pro Glu Pro Leu Phe Pro Phe Ser His Phe Arg 
        435                 440                 445             


Gln Phe Ile Ala Ala Ile Lys Leu Gln Asp Gln Ala Arg Arg Ser Arg 
    450                 455                 460                 


Cys Val Arg Asp Leu Val Arg Ser Leu Pro Ala Pro Asn His Asp Xaa 
465                 470                 475                 480 


Leu Arg Met Leu Phe Gln His Leu Cys Arg Val Ile Glu His Gly Glu 
                485                 490                 495     


Gln Asn Arg Met Ser Val Gln Ser Val Ala Ile Val Phe Gly Pro Xaa 
            500                 505                 510         


Leu Leu Arg Pro Glu Val Glu Glu Xaa Ser Met Pro Met Xaa Met Val 
        515                 520                 525             


Phe Gln Asn Gln Val Val Glu Leu Ile Leu Gln Gln Cys Ala Asp Ile 
    530                 535                 540                 


Phe Pro Pro His 
545             


<210> 2809
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 2809
Met Gln Pro Gly Leu Ser Pro Gly Ser Pro Gly Asp Pro Arg Pro Pro 
1               5                   10                  15      


Xaa Pro Glu Xaa Asp Tyr Pro Glu Ser Leu Xaa Ser Tyr Pro Glu Glu 
            20                  25                  30          


Asp Tyr Ser Pro Val Gly Ser Phe Val Gly Glu Ala Gly Gly Pro Pro 
        35                  40                  45              


Arg Glu Ala Ile Leu Leu Gln Ser Arg Gly Leu Leu Cys Ser Met Gly 
    50                  55                  60                  


Ala Ala Pro Gly Pro Cys Pro Cys Pro Ser Lys His Pro 
65                  70                  75          


<210> 2810
<211> 214
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<400> 2810
Met Val Asp Ile Ile Ala Lys Val Xaa Arg Arg Gln Ser Arg Ala Leu 
1               5                   10                  15      


Pro Ala Gln Val Asp Asp Pro Pro Glu Pro Val Tyr Ala Asn Ile Glu 
            20                  25                  30          


Arg Gln Pro Arg Ala Xaa Ser Pro Gly Ala Ala Ala Ala Pro Leu Pro 
        35                  40                  45              


Ser Pro Val Trp Glu Xaa His Xaa Asp Ala Gly Xaa Gly Arg Pro Tyr 
    50                  55                  60                  


Tyr Tyr Asn Pro Asp Xaa Gly Val Xaa Xaa Trp Glu Ser Pro Phe Glu 
65                  70                  75                  80  


Ala Ala Glu Gly Ala Ala Ser Pro Ala Xaa Ser Pro Ala Ser Val Asp 
                85                  90                  95      


Ser His Pro Pro Xaa Pro Glu Xaa Asp Tyr Pro Glu Ser Leu Xaa Ser 
            100                 105                 110         


Tyr Pro Glu Glu Asp Tyr Ser Pro Val Gly Ser Phe Gly Glu Pro Gly 
        115                 120                 125             


Pro Xaa Ser Pro Leu Xaa Xaa Pro Pro Gly Trp Ser Cys His Val Ser 
    130                 135                 140                 


Gln Asp Lys Gln Met Leu Tyr Xaa Asn His Phe Xaa Gln Glu Gln Trp 
145                 150                 155                 160 


Val Arg Leu Glu Asp Pro His Gly Lys Pro Tyr Phe Tyr Asn Pro Glu 
                165                 170                 175     


Asp Ser Ser Val Arg Trp Glu Leu Pro Gln Val Pro Val Pro Ala Pro 
            180                 185                 190         


Arg Ser Ile His Lys Ser Ser Gln Asp Gly Asp Xaa Pro Ala Gln Ala 
        195                 200                 205             


Ser Pro Pro Glu Glu Lys 
    210                 


<210> 2811
<211> 667
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<400> 2811
Met Val Asp Ile Ile Ala Lys Val Xaa Arg Arg Gln Ser Arg Ala Leu 
1               5                   10                  15      


Pro Ala Gln Val Asp Asp Pro Pro Glu Pro Val Tyr Ala Asn Ile Glu 
            20                  25                  30          


Arg Gln Pro Arg Ala Xaa Ser Pro Gly Ala Ala Ala Ala Pro Leu Pro 
        35                  40                  45              


Ser Pro Val Trp Glu Xaa His Xaa Asp Ala Gly Xaa Gly Arg Pro Tyr 
    50                  55                  60                  


Tyr Tyr Asn Pro Asp Xaa Gly Val Xaa Xaa Trp Glu Ser Pro Phe Glu 
65                  70                  75                  80  


Ala Ala Glu Gly Ala Ala Ser Pro Ala Xaa Ser Pro Ala Ser Val Asp 
                85                  90                  95      


Ser His Val Ser Leu Glu Xaa Glu Trp Gly Gln Tyr Trp Asp Glu Glu 
            100                 105                 110         


Ser Arg Arg Val Phe Phe Tyr Asn Pro Leu Xaa Gly Glu Xaa Ala Trp 
        115                 120                 125             


Glu Asp Glu Ala Glu Asn Glu Pro Glu Glu Glu Leu Glu Met Gln Pro 
    130                 135                 140                 


Gly Leu Ser Pro Gly Ser Pro Gly Asp Pro Arg Pro Pro Xaa Pro Glu 
145                 150                 155                 160 


Xaa Asp Tyr Pro Glu Ser Leu Xaa Ser Tyr Pro Glu Glu Asp Tyr Ser 
                165                 170                 175     


Pro Val Gly Ser Phe Gly Glu Pro Gly Pro Xaa Ser Pro Leu Xaa Xaa 
            180                 185                 190         


Pro Pro Gly Trp Ser Cys His Val Ser Gln Asp Lys Gln Met Leu Tyr 
        195                 200                 205             


Xaa Asn His Phe Xaa Gln Glu Gln Trp Val Arg Leu Glu Asp Pro His 
    210                 215                 220                 


Gly Lys Pro Tyr Phe Tyr Asn Pro Glu Asp Ser Ser Val Arg Trp Glu 
225                 230                 235                 240 


Leu Pro Gln Val Pro Val Pro Ala Pro Arg Ser Ile His Lys Ser Ser 
                245                 250                 255     


Gln Asp Gly Asp Xaa Pro Ala Gln Ala Ser Pro Pro Glu Glu Lys Xaa 
            260                 265                 270         


Lys Xaa Leu Asp Lys Ala Gly Val Leu His Arg Xaa Lys Xaa Ala Asp 
        275                 280                 285             


Lys Gly Lys Arg Leu Arg Lys Lys His Trp Ser Ala Ser Trp Xaa Val 
    290                 295                 300                 


Leu Glu Gly Gly Val Leu Xaa Phe Phe Lys Asp Ser Lys Xaa Ser Ala 
305                 310                 315                 320 


Ala Gly Gly Leu Arg Gln Pro Ser Lys Phe Ser Xaa Pro Glu Tyr Xaa 
                325                 330                 335     


Val Glu Leu Arg Gly Ala Xaa Leu Ser Trp Ala Pro Lys Asp Lys Ser 
            340                 345                 350         


Ser Arg Lys Asn Val Leu Glu Leu Arg Ser Arg Asp Gly Ser Glu Tyr 
        355                 360                 365             


Leu Ile Gln His Asp Ser Glu Ala Ile Ile Ser Xaa Trp His Lys Ala 
    370                 375                 380                 


Ile Ala Gln Gly Ile Gln Glu Leu Ser Ala Glu Leu Pro Pro Glu Glu 
385                 390                 395                 400 


Ser Glu Ser Ser Arg Val Asp Phe Gly Ser Ser Glu Arg Leu Gly Ser 
                405                 410                 415     


Trp Gln Glu Lys Glu Glu Asp Ala Arg Pro Asn Ala Ala Ala Pro Ala 
            420                 425                 430         


Leu Gly Pro Val Gly Leu Glu Ser Asp Leu Ser Lys Val Arg His Lys 
        435                 440                 445             


Leu Arg Lys Phe Leu Gln Arg Arg Pro Xaa Leu Gln Ser Leu Arg Glu 
    450                 455                 460                 


Lys Gly Tyr Ile Lys Asp Gln Val Phe Gly Cys Ala Leu Ala Ala Leu 
465                 470                 475                 480 


Cys Glu Arg Glu Arg Ser Arg Val Pro Arg Phe Val Gln Gln Cys Ile 
                485                 490                 495     


Arg Ala Val Glu Ala Arg Gly Leu Asp Ile Asp Gly Leu Tyr Arg Ile 
            500                 505                 510         


Ser Gly Asn Leu Ala Xaa Ile Gln Lys Leu Arg Tyr Lys Val Asp His 
        515                 520                 525             


Asp Glu Arg Leu Asp Leu Asp Asp Gly Arg Trp Glu Asp Val His Val 
    530                 535                 540                 


Ile Xaa Gly Ala Leu Lys Leu Phe Phe Arg Glu Leu Pro Glu Pro Leu 
545                 550                 555                 560 


Phe Pro Phe Ser His Phe Arg Gln Phe Ile Ala Ala Ile Lys Leu Gln 
                565                 570                 575     


Asp Gln Ala Arg Arg Ser Arg Cys Val Arg Asp Leu Val Arg Ser Leu 
            580                 585                 590         


Pro Ala Pro Asn His Asp Xaa Leu Arg Met Leu Phe Gln His Leu Cys 
        595                 600                 605             


Arg Val Ile Glu His Gly Glu Gln Asn Arg Met Ser Val Gln Ser Val 
    610                 615                 620                 


Ala Ile Val Phe Gly Pro Xaa Leu Leu Arg Pro Glu Val Glu Glu Xaa 
625                 630                 635                 640 


Ser Met Pro Met Xaa Met Val Phe Gln Asn Gln Val Val Glu Leu Ile 
                645                 650                 655     


Leu Gln Gln Cys Ala Asp Ile Phe Pro Pro His 
            660                 665         


<210> 2812
<211> 202
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<400> 2812
Glu Asp Met Lys Lys Ile Arg His Leu Ser Leu Ile Glu Leu Xaa Ala 
1               5                   10                  15      


Phe Phe Asp Ala Phe Gly Ile Gln Leu Lys Arg Asn Lys Xaa Glu Lys 
            20                  25                  30          


Val Lys Gly Arg Asp Asn Gly Ile Phe Gly Val Pro Leu Xaa Val Leu 
        35                  40                  45              


Leu Asp Gly Asp Arg Lys Lys Asp Pro Gly Val Lys Val Pro Leu Val 
    50                  55                  60                  


Leu Gln Lys Gln Tyr Arg Glu Glu Leu Asp Ala Lys Phe Asn Ala Asp 
65                  70                  75                  80  


Lys Phe Lys Trp Asp Lys Met Cys His Arg Glu Ala Ala Val Met Leu 
                85                  90                  95      


Lys Ala Phe Phe Arg Glu Leu Pro Xaa Ser Leu Phe Pro Val Glu Tyr 
            100                 105                 110         


Ile Pro Ala Phe Ile Ser Leu Met Glu Arg Gly Pro His Val Lys Val 
        115                 120                 125             


Gln Phe Gln Ala Leu His Leu Met Val Met Ala Leu Pro Asp Ala Asn 
    130                 135                 140                 


Arg Asp Ala Ala Gln Ala Leu Met Xaa Phe Phe Asn Lys Val Ile Ala 
145                 150                 155                 160 


Asn Glu Ser Lys Asn Arg Met Ser Leu Trp Asn Ile Ser Xaa Val Met 
                165                 170                 175     


Ala Pro Asn Leu Phe Phe Ser Arg Ser Lys His Ser Asp Tyr Glu Glu 
            180                 185                 190         


Leu Leu Leu Ala Asn Xaa Ala Ala His Ile 
        195                 200         


<210> 2813
<211> 729
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<400> 2813
Met Glu Val Glu Asp Ser Gly Gly Val Val Leu Xaa Ala Tyr His Ser 
1               5                   10                  15      


Tyr Ala Arg Ala Gln Pro Pro Asn Ala Glu Ser Arg Cys Ala Pro Arg 
            20                  25                  30          


Ala Ala Ala Ser His Pro Leu Ser Arg Lys Ser Ile Pro Arg Cys Arg 
        35                  40                  45              


Arg Ile Asn Arg Met Leu Ser Asn Glu Ser Leu His Pro Pro Ala Phe 
    50                  55                  60                  


Ser Arg Ser Asn Ser Glu Ala Ser Val Asp Ser Ala Ser Met Glu Asp 
65                  70                  75                  80  


Phe Trp Arg Glu Ile Glu Ser Ile Lys Asp Ser Ser Met Gly Gly Gln 
                85                  90                  95      


Glu Glu Pro Pro Pro Ala Glu Val Xaa Pro Val Asp Glu Gly Glu Leu 
            100                 105                 110         


Glu Ala Glu Trp Leu Gln Asp Val Gly Leu Ser Xaa Leu Ile Ser Gly 
        115                 120                 125             


Asp Glu Glu Glu Asp Gly Lys Ala Leu Leu Ser Xaa Leu Xaa Arg Xaa 
    130                 135                 140                 


Gln Ala Ala Ala Val Gln Lys Arg Tyr His Xaa Tyr Xaa Gln Xaa Met 
145                 150                 155                 160 


Arg Lys Lys Asp Lys Gln Ser Ile Arg Asp Val Arg Asp Ile Phe Gly 
                165                 170                 175     


Val Ser Glu Ser Pro Pro Arg Asp Xaa Cys Gly Asn His Xaa Asn Gln 
            180                 185                 190         


Leu Asp Gly Xaa Lys Glu Glu Arg Glu Leu Pro Arg Val Ile Lys Xaa 
        195                 200                 205             


Ser Gly Ser Met Pro Asp Asp Ala Ser Leu Asn Ser Xaa Xaa Leu Ser 
    210                 215                 220                 


Asp Ala Ser Gln Asp Lys Glu Gly Ser Phe Ala Val Pro Arg Ser Asp 
225                 230                 235                 240 


Ser Val Ala Ile Leu Glu Xaa Ile Pro Val Leu Pro Val His Ser Asn 
                245                 250                 255     


Gly Ser Pro Glu Pro Gly Gln Pro Val Gln Asn Ala Ile Ser Asp Asp 
            260                 265                 270         


Asp Phe Leu Glu Lys Asn Ile Pro Pro Glu Ala Glu Glu Leu Ser Phe 
        275                 280                 285             


Glu Val Ser Tyr Ser Glu Met Val Xaa Glu Ala Leu Lys Arg Asn Lys 
    290                 295                 300                 


Leu Lys Lys Ser Glu Ile Lys Lys Glu Asp Tyr Val Leu Xaa Lys Phe 
305                 310                 315                 320 


Asn Val Gln Lys Xaa Arg Phe Gly Leu Xaa Glu Ala Gly Asp Leu Ser 
                325                 330                 335     


Ala Glu Asp Met Lys Lys Ile Arg His Leu Ser Leu Ile Glu Leu Xaa 
            340                 345                 350         


Ala Phe Phe Asp Ala Phe Gly Ile Gln Leu Lys Arg Asn Lys Xaa Glu 
        355                 360                 365             


Lys Val Lys Gly Arg Asp Asn Gly Ile Phe Gly Val Pro Leu Xaa Val 
    370                 375                 380                 


Leu Leu Asp Gly Asp Arg Lys Lys Asp Pro Gly Val Lys Val Pro Leu 
385                 390                 395                 400 


Val Leu Gln Lys Phe Phe Glu Lys Val Glu Glu Ser Gly Leu Glu Ser 
                405                 410                 415     


Glu Gly Ile Phe Arg Leu Ser Gly Cys Xaa Ala Lys Val Lys Gln Tyr 
            420                 425                 430         


Arg Glu Glu Leu Asp Ala Lys Phe Asn Ala Asp Lys Phe Lys Trp Asp 
        435                 440                 445             


Lys Met Cys His Arg Glu Ala Ala Val Met Leu Lys Ala Phe Phe Arg 
    450                 455                 460                 


Glu Leu Pro Xaa Ser Leu Phe Pro Val Glu Tyr Ile Pro Ala Phe Ile 
465                 470                 475                 480 


Ser Leu Met Glu Arg Gly Pro His Val Lys Val Gln Phe Gln Ala Leu 
                485                 490                 495     


His Leu Met Val Met Ala Leu Pro Asp Ala Asn Arg Asp Ala Ala Gln 
            500                 505                 510         


Ala Leu Met Xaa Phe Phe Asn Lys Val Ile Ala Asn Glu Ser Lys Asn 
        515                 520                 525             


Arg Met Ser Leu Trp Asn Ile Ser Xaa Val Met Ala Pro Asn Leu Phe 
    530                 535                 540                 


Phe Ser Arg Ser Lys His Ser Asp Tyr Glu Glu Leu Leu Leu Ala Asn 
545                 550                 555                 560 


Xaa Ala Ala His Ile Ile Arg Leu Met Leu Lys Tyr Gln Lys Ile Leu 
                565                 570                 575     


Trp Lys Val Pro Ser Phe Leu Ile Xaa Gln Val Arg Arg Met Asn Glu 
            580                 585                 590         


Ala Xaa Met Leu Leu Lys Lys Gln Leu Pro Ser Val Arg Lys Leu Leu 
        595                 600                 605             


Arg Arg Lys Xaa Leu Glu Arg Glu Xaa Ala Ser Pro Lys Xaa Ser Lys 
    610                 615                 620                 


Val Leu Gln Lys Ser Pro Ser Ala Arg Arg Met Ser Asp Val Pro Glu 
625                 630                 635                 640 


Gly Val Ile Arg Val His Ala Pro Leu Leu Ser Lys Val Ser Met Ala 
                645                 650                 655     


Ile Gln Leu Asn Asn Gln Xaa Lys Ala Lys Asp Ile Leu Ala Lys Phe 
            660                 665                 670         


Gln Tyr Glu Asn Ser His Gly Ser Ser Glu Cys Ile Lys Ile Gln Asn 
        675                 680                 685             


Gln Arg Leu Tyr Glu Ile Gly Gly Asn Ile Gly Glu His Cys Leu Asp 
    690                 695                 700                 


Pro Asp Ala Tyr Ile Leu Asp Val Tyr Arg Ile Asn Pro Gln Ala Glu 
705                 710                 715                 720 


Trp Val Ile Lys Pro Gln Gln Ser Ser 
                725                 


<210> 2814
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<400> 2814
Met Leu Ser Asn Glu Ser Leu His Pro Pro Ala Phe Ser Arg Ser Asn 
1               5                   10                  15      


Ser Glu Ala Ser Val Asp Ser Ala Ser Met Glu Asp Phe Trp Arg Glu 
            20                  25                  30          


Ile Glu Ser Ile Lys Asp Ser Ser Met Gly Gly Gln Glu Glu Pro Pro 
        35                  40                  45              


Pro Ala Glu Val Xaa Pro Val Asp Glu Gly Glu Leu Glu Ala Glu Trp 
    50                  55                  60                  


Leu Gln Asp Val Gly Leu Ser Xaa Leu Ile Ser Gly Asp Glu Glu Glu 
65                  70                  75                  80  


Asp Gly Lys Ala Leu Leu Ser Xaa Leu Xaa Arg Xaa Gln Ala Ala Ala 
                85                  90                  95      


Val Gln Lys Arg Tyr His Xaa Tyr Xaa Gln Xaa Met Arg Lys Lys Asp 
            100                 105                 110         


Lys Gln Ser Ile Arg 
        115         


<210> 2815
<211> 670
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<400> 2815
Met Leu Ser Asn Glu Ser Leu His Pro Pro Ala Phe Ser Arg Ser Asn 
1               5                   10                  15      


Ser Glu Ala Ser Val Asp Ser Ala Ser Met Glu Asp Phe Trp Arg Glu 
            20                  25                  30          


Ile Glu Ser Ile Lys Asp Ser Ser Met Gly Gly Gln Glu Glu Pro Pro 
        35                  40                  45              


Pro Ala Glu Val Xaa Pro Val Asp Glu Gly Glu Leu Glu Ala Glu Trp 
    50                  55                  60                  


Leu Gln Asp Val Gly Leu Ser Xaa Leu Ile Ser Gly Asp Glu Glu Glu 
65                  70                  75                  80  


Asp Gly Lys Ala Leu Leu Ser Xaa Leu Xaa Arg Xaa Gln Ala Ala Ala 
                85                  90                  95      


Val Gln Lys Arg Tyr His Xaa Tyr Xaa Gln Xaa Met Arg Lys Lys Asp 
            100                 105                 110         


Lys Gln Ser Ile Arg Asp Val Arg Asp Ile Phe Gly Val Ser Glu Ser 
        115                 120                 125             


Pro Pro Arg Asp Xaa Cys Gly Asn His Xaa Asn Gln Leu Asp Gly Xaa 
    130                 135                 140                 


Lys Glu Glu Arg Glu Leu Pro Arg Val Ile Lys Xaa Ser Gly Ser Met 
145                 150                 155                 160 


Pro Asp Asp Ala Ser Leu Asn Ser Xaa Xaa Leu Ser Asp Ala Ser Gln 
                165                 170                 175     


Asp Lys Glu Gly Ser Phe Ala Val Pro Arg Ser Asp Ser Val Ala Ile 
            180                 185                 190         


Leu Glu Xaa Ile Pro Val Leu Pro Val His Ser Asn Gly Ser Pro Glu 
        195                 200                 205             


Pro Gly Gln Pro Val Gln Asn Ala Ile Ser Asp Asp Asp Phe Leu Glu 
    210                 215                 220                 


Lys Asn Ile Pro Pro Glu Ala Glu Glu Leu Ser Phe Glu Val Ser Tyr 
225                 230                 235                 240 


Ser Glu Met Val Xaa Glu Ala Leu Lys Arg Asn Lys Leu Lys Lys Ser 
                245                 250                 255     


Glu Ile Lys Lys Glu Asp Tyr Val Leu Xaa Lys Phe Asn Val Gln Lys 
            260                 265                 270         


Xaa Arg Phe Gly Leu Xaa Glu Ala Gly Asp Leu Ser Ala Glu Asp Met 
        275                 280                 285             


Lys Lys Ile Arg His Leu Ser Leu Ile Glu Leu Xaa Ala Phe Phe Asp 
    290                 295                 300                 


Ala Phe Gly Ile Gln Leu Lys Arg Asn Lys Xaa Glu Lys Val Lys Gly 
305                 310                 315                 320 


Arg Asp Asn Gly Ile Phe Gly Val Pro Leu Xaa Val Leu Leu Asp Gly 
                325                 330                 335     


Asp Arg Lys Lys Asp Pro Gly Val Lys Val Pro Leu Val Leu Gln Lys 
            340                 345                 350         


Phe Phe Glu Lys Val Glu Glu Ser Gly Leu Glu Ser Glu Gly Ile Phe 
        355                 360                 365             


Arg Leu Ser Gly Cys Xaa Ala Lys Val Lys Gln Tyr Arg Glu Glu Leu 
    370                 375                 380                 


Asp Ala Lys Phe Asn Ala Asp Lys Phe Lys Trp Asp Lys Met Cys His 
385                 390                 395                 400 


Arg Glu Ala Ala Val Met Leu Lys Ala Phe Phe Arg Glu Leu Pro Xaa 
                405                 410                 415     


Ser Leu Phe Pro Val Glu Tyr Ile Pro Ala Phe Ile Ser Leu Met Glu 
            420                 425                 430         


Arg Gly Pro His Val Lys Val Gln Phe Gln Ala Leu His Leu Met Val 
        435                 440                 445             


Met Ala Leu Pro Asp Ala Asn Arg Asp Ala Ala Gln Ala Leu Met Xaa 
    450                 455                 460                 


Phe Phe Asn Lys Val Ile Ala Asn Glu Ser Lys Asn Arg Met Ser Leu 
465                 470                 475                 480 


Trp Asn Ile Ser Xaa Val Met Ala Pro Asn Leu Phe Phe Ser Arg Ser 
                485                 490                 495     


Lys His Ser Asp Tyr Glu Glu Leu Leu Leu Ala Asn Xaa Ala Ala His 
            500                 505                 510         


Ile Ile Arg Leu Met Leu Lys Tyr Gln Lys Ile Leu Trp Lys Val Pro 
        515                 520                 525             


Ser Phe Leu Ile Xaa Gln Val Arg Arg Met Asn Glu Ala Xaa Met Leu 
    530                 535                 540                 


Leu Lys Lys Gln Leu Pro Ser Val Arg Lys Leu Leu Arg Arg Lys Xaa 
545                 550                 555                 560 


Leu Glu Arg Glu Xaa Ala Ser Pro Lys Xaa Ser Lys Val Leu Gln Lys 
                565                 570                 575     


Ser Pro Ser Ala Arg Arg Met Ser Asp Val Pro Glu Gly Val Ile Arg 
            580                 585                 590         


Val His Ala Pro Leu Leu Ser Lys Val Ser Met Ala Ile Gln Leu Asn 
        595                 600                 605             


Asn Gln Xaa Lys Ala Lys Asp Ile Leu Ala Lys Phe Gln Tyr Glu Asn 
    610                 615                 620                 


Arg Ile Leu His Trp Gln Arg Ala Ala Leu Ser Phe Leu Asn Gly Lys 
625                 630                 635                 640 


Trp Val Lys Lys Glu Arg Glu Glu Ser Xaa Glu Xaa Asn Arg Ser Pro 
                645                 650                 655     


Lys His Val Phe Leu Phe Xaa Ile Gly Leu Asp Ile Ser Xaa 
            660                 665                 670 


<210> 2816
<211> 545
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<400> 2816
Met Asn Glu Leu Pro Arg Asp Xaa Cys Gly Asn His Xaa Asn Gln Leu 
1               5                   10                  15      


Asp Gly Xaa Lys Glu Glu Arg Glu Leu Pro Arg Val Ile Lys Xaa Ser 
            20                  25                  30          


Gly Ser Met Pro Asp Asp Ala Ser Leu Asn Ser Xaa Xaa Leu Ser Asp 
        35                  40                  45              


Ala Ser Gln Asp Lys Glu Gly Ser Phe Ala Val Pro Arg Ser Asp Ser 
    50                  55                  60                  


Val Ala Ile Leu Glu Xaa Ile Pro Val Leu Pro Val His Ser Asn Gly 
65                  70                  75                  80  


Ser Pro Glu Pro Gly Gln Pro Val Gln Asn Ala Ile Ser Asp Asp Asp 
                85                  90                  95      


Phe Leu Glu Lys Asn Ile Pro Pro Glu Ala Glu Glu Leu Ser Phe Glu 
            100                 105                 110         


Val Ser Tyr Ser Glu Met Val Xaa Glu Ala Leu Lys Arg Asn Lys Leu 
        115                 120                 125             


Lys Lys Ser Glu Ile Lys Lys Glu Asp Tyr Val Leu Xaa Lys Phe Asn 
    130                 135                 140                 


Val Gln Lys Xaa Arg Phe Gly Leu Xaa Glu Ala Gly Asp Leu Ser Ala 
145                 150                 155                 160 


Glu Asp Met Lys Lys Ile Arg His Leu Ser Leu Ile Glu Leu Xaa Ala 
                165                 170                 175     


Phe Phe Asp Ala Phe Gly Ile Gln Leu Lys Arg Asn Lys Xaa Glu Lys 
            180                 185                 190         


Val Lys Gly Arg Asp Asn Gly Ile Phe Gly Val Pro Leu Xaa Val Leu 
        195                 200                 205             


Leu Asp Gly Asp Arg Lys Lys Asp Pro Gly Val Lys Val Pro Leu Val 
    210                 215                 220                 


Leu Gln Lys Phe Phe Glu Lys Val Glu Glu Ser Gly Leu Glu Ser Glu 
225                 230                 235                 240 


Gly Ile Phe Arg Leu Ser Gly Cys Xaa Ala Lys Val Lys Gln Tyr Arg 
                245                 250                 255     


Glu Glu Leu Asp Ala Lys Phe Asn Ala Asp Lys Phe Lys Trp Asp Lys 
            260                 265                 270         


Met Cys His Arg Glu Ala Ala Val Met Leu Lys Ala Phe Phe Arg Glu 
        275                 280                 285             


Leu Pro Xaa Ser Leu Phe Pro Val Glu Tyr Ile Pro Ala Phe Ile Ser 
    290                 295                 300                 


Leu Met Glu Arg Gly Pro His Val Lys Val Gln Phe Gln Ala Leu His 
305                 310                 315                 320 


Leu Met Val Met Ala Leu Pro Asp Ala Asn Arg Asp Ala Ala Gln Ala 
                325                 330                 335     


Leu Met Xaa Phe Phe Asn Lys Val Ile Ala Asn Glu Ser Lys Asn Arg 
            340                 345                 350         


Met Ser Leu Trp Asn Ile Ser Xaa Val Met Ala Pro Asn Leu Phe Phe 
        355                 360                 365             


Ser Arg Ser Lys His Ser Asp Tyr Glu Glu Leu Leu Leu Ala Asn Xaa 
    370                 375                 380                 


Ala Ala His Ile Ile Arg Leu Met Leu Lys Tyr Gln Lys Ile Leu Trp 
385                 390                 395                 400 


Lys Val Pro Ser Phe Leu Ile Xaa Gln Val Arg Arg Met Asn Glu Ala 
                405                 410                 415     


Xaa Met Leu Leu Lys Lys Gln Leu Pro Ser Val Arg Lys Leu Leu Arg 
            420                 425                 430         


Arg Lys Xaa Leu Glu Arg Glu Xaa Ala Ser Pro Lys Xaa Ser Lys Val 
        435                 440                 445             


Leu Gln Lys Ser Pro Ser Ala Arg Arg Met Ser Asp Val Pro Glu Gly 
    450                 455                 460                 


Val Ile Arg Val His Ala Pro Leu Leu Ser Lys Val Ser Met Ala Ile 
465                 470                 475                 480 


Gln Leu Asn Asn Gln Xaa Lys Ala Lys Asp Ile Leu Ala Lys Phe Gln 
                485                 490                 495     


Tyr Glu Asn Arg Ile Leu His Trp Gln Arg Ala Ala Leu Ser Phe Leu 
            500                 505                 510         


Asn Gly Lys Trp Val Lys Lys Glu Arg Glu Glu Ser Xaa Glu Xaa Asn 
        515                 520                 525             


Arg Ser Pro Lys His Val Phe Leu Phe Xaa Ile Gly Leu Asp Ile Ser 
    530                 535                 540                 


Xaa 
545 


<210> 2817
<211> 73
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<400> 2817
Met Asn Leu Ile Gln Gly Lys Ser Ile Pro Arg Cys Arg Arg Ile Asn 
1               5                   10                  15      


Arg Met Leu Ser Asn Glu Ser Leu His Pro Pro Ala Phe Ser Arg Ser 
            20                  25                  30          


Asn Ser Glu Ala Ser Val Asp Ser Ala Ser Met Glu Asp Phe Trp Arg 
        35                  40                  45              


Glu Ile Glu Ser Ile Lys Asp Ser Ser Met Gly Gly Gln Glu Glu Pro 
    50                  55                  60                  


Pro Pro Ala Glu Val Xaa Pro Val Asp 
65                  70              


<210> 2818
<211> 565
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<400> 2818
Met Arg Lys Lys Asp Lys Gln Ser Ile Arg Asp Val Arg Asp Ile Phe 
1               5                   10                  15      


Gly Val Ser Glu Ser Pro Pro Arg Asp Xaa Cys Gly Asn His Xaa Asn 
            20                  25                  30          


Gln Leu Asp Gly Xaa Lys Glu Glu Arg Glu Leu Pro Arg Val Ile Lys 
        35                  40                  45              


Xaa Asn Asp Ala Ser Leu Asn Ser Xaa Xaa Leu Ser Asp Ala Ser Gln 
    50                  55                  60                  


Asp Lys Glu Gly Ser Phe Ala Val Pro Arg Ser Asp Ser Val Ala Ile 
65                  70                  75                  80  


Leu Glu Xaa Ile Pro Val Leu Pro Val His Ser Asn Gly Ser Pro Glu 
                85                  90                  95      


Pro Gly Gln Pro Val Gln Asn Ala Ile Ser Asp Asp Asp Phe Leu Glu 
            100                 105                 110         


Lys Asn Ile Pro Pro Glu Ala Glu Glu Leu Ser Phe Glu Val Ser Tyr 
        115                 120                 125             


Ser Glu Met Val Xaa Glu Ala Leu Lys Arg Asn Lys Leu Lys Lys Ser 
    130                 135                 140                 


Glu Ile Lys Lys Glu Asp Tyr Val Leu Xaa Lys Phe Asn Val Gln Lys 
145                 150                 155                 160 


Xaa Arg Phe Gly Leu Xaa Glu Ala Gly Asp Leu Ser Ala Glu Asp Met 
                165                 170                 175     


Lys Lys Ile Arg His Leu Ser Leu Ile Glu Leu Xaa Ala Phe Phe Asp 
            180                 185                 190         


Ala Phe Gly Ile Gln Leu Lys Arg Asn Lys Xaa Glu Lys Val Lys Gly 
        195                 200                 205             


Arg Asp Asn Gly Ile Phe Gly Val Pro Leu Xaa Val Leu Leu Asp Gly 
    210                 215                 220                 


Asp Arg Lys Lys Asp Pro Gly Val Lys Val Pro Leu Val Leu Gln Lys 
225                 230                 235                 240 


Phe Phe Glu Lys Val Glu Glu Ser Gly Leu Glu Ser Glu Gly Ile Phe 
                245                 250                 255     


Arg Leu Ser Gly Cys Xaa Ala Lys Val Lys Gln Tyr Arg Glu Glu Leu 
            260                 265                 270         


Asp Ala Lys Phe Asn Ala Asp Lys Phe Lys Trp Asp Lys Met Cys His 
        275                 280                 285             


Arg Glu Ala Ala Val Met Leu Lys Ala Phe Phe Arg Glu Leu Pro Xaa 
    290                 295                 300                 


Ser Leu Phe Pro Val Glu Tyr Ile Pro Ala Phe Ile Ser Leu Met Glu 
305                 310                 315                 320 


Arg Gly Pro His Val Lys Val Gln Phe Gln Ala Leu His Leu Met Val 
                325                 330                 335     


Met Ala Leu Pro Asp Ala Asn Arg Asp Ala Ala Gln Ala Leu Met Xaa 
            340                 345                 350         


Phe Phe Asn Lys Val Ile Ala Asn Glu Ser Lys Asn Arg Met Ser Leu 
        355                 360                 365             


Trp Asn Ile Ser Xaa Val Met Ala Pro Asn Leu Phe Phe Ser Arg Ser 
    370                 375                 380                 


Lys His Ser Asp Tyr Glu Glu Leu Leu Leu Ala Asn Xaa Ala Ala His 
385                 390                 395                 400 


Ile Ile Arg Leu Met Leu Lys Tyr Gln Lys Ile Leu Trp Lys Val Pro 
                405                 410                 415     


Ser Phe Leu Ile Xaa Gln Val Arg Arg Met Asn Glu Ala Xaa Met Leu 
            420                 425                 430         


Leu Lys Lys Gln Leu Pro Ser Val Arg Lys Leu Leu Arg Arg Lys Xaa 
        435                 440                 445             


Leu Glu Arg Glu Xaa Ala Ser Pro Lys Xaa Ser Lys Val Leu Gln Lys 
    450                 455                 460                 


Ser Pro Ser Ala Arg Arg Met Ser Asp Val Pro Glu Gly Val Ile Arg 
465                 470                 475                 480 


Val His Ala Pro Leu Leu Ser Lys Val Ser Met Ala Ile Gln Leu Asn 
                485                 490                 495     


Asn Gln Xaa Lys Ala Lys Asp Ile Leu Ala Lys Phe Gln Tyr Glu Asn 
            500                 505                 510         


Ser His Gly Ser Ser Glu Cys Ile Lys Ile Gln Asn Gln Arg Leu Tyr 
        515                 520                 525             


Glu Ile Gly Gly Asn Ile Gly Glu His Cys Leu Asp Pro Asp Ala Tyr 
    530                 535                 540                 


Ile Leu Asp Val Tyr Arg Ile Asn Pro Gln Ala Glu Trp Val Ile Lys 
545                 550                 555                 560 


Pro Gln Gln Ser Ser 
                565 


<210> 2819
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 2819
Met Arg Lys Lys Asp Lys Gln Ser Ile Arg Asp Val Arg Asp Ile Phe 
1               5                   10                  15      


Gly Val Ser Glu Ser Pro Pro Arg Asp Xaa Cys Gly Asn His Xaa Asn 
            20                  25                  30          


Gln Leu Asp Gly Xaa Lys Glu Glu Arg Glu Leu Pro Arg Val Ile Lys 
        35                  40                  45              


Xaa Ser Gly Ser Met Pro Asp Asp Ala Ser Leu Asn Ser Xaa Xaa Leu 
    50                  55                  60                  


Ser Asp Ala Ser Gln Asp Lys Glu Gly Ser Phe Ala Val Pro Arg Ser 
65                  70                  75                  80  


Asp Ser Val Ala Ile Leu Glu Xaa Ile Pro Val Leu Pro Val His Ser 
                85                  90                  95      


Asn Gly Ser Pro Glu Pro Gly Gln Pro Val Gln Asn Ala Ile Ser 
            100                 105                 110     


<210> 2820
<211> 570
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<400> 2820
Met Arg Lys Lys Asp Lys Gln Ser Ile Arg Asp Val Arg Asp Ile Phe 
1               5                   10                  15      


Gly Val Ser Glu Ser Pro Pro Arg Asp Xaa Cys Gly Asn His Xaa Asn 
            20                  25                  30          


Gln Leu Asp Gly Xaa Lys Glu Glu Arg Glu Leu Pro Arg Val Ile Lys 
        35                  40                  45              


Xaa Ser Gly Ser Met Pro Asp Asp Ala Ser Leu Asn Ser Xaa Xaa Leu 
    50                  55                  60                  


Ser Asp Ala Ser Gln Asp Lys Glu Gly Ser Phe Ala Val Pro Arg Ser 
65                  70                  75                  80  


Asp Ser Val Ala Ile Leu Glu Xaa Ile Pro Val Leu Pro Val His Ser 
                85                  90                  95      


Asn Gly Ser Pro Glu Pro Gly Gln Pro Val Gln Asn Ala Ile Ser Asp 
            100                 105                 110         


Asp Asp Phe Leu Glu Lys Asn Ile Pro Pro Glu Ala Glu Glu Leu Ser 
        115                 120                 125             


Phe Glu Val Ser Tyr Ser Glu Met Val Xaa Glu Ala Leu Lys Arg Asn 
    130                 135                 140                 


Lys Leu Lys Lys Ser Glu Ile Lys Lys Glu Asp Tyr Val Leu Xaa Lys 
145                 150                 155                 160 


Phe Asn Val Gln Lys Xaa Arg Phe Gly Leu Xaa Glu Ala Gly Asp Leu 
                165                 170                 175     


Ser Ala Glu Asp Met Lys Lys Ile Arg His Leu Ser Leu Ile Glu Leu 
            180                 185                 190         


Xaa Ala Phe Phe Asp Ala Phe Gly Ile Gln Leu Lys Arg Asn Lys Xaa 
        195                 200                 205             


Glu Lys Val Lys Gly Arg Asp Asn Gly Ile Phe Gly Val Pro Leu Xaa 
    210                 215                 220                 


Val Leu Leu Asp Gly Asp Arg Lys Lys Asp Pro Gly Val Lys Val Pro 
225                 230                 235                 240 


Leu Val Leu Gln Lys Phe Phe Glu Lys Val Glu Glu Ser Gly Leu Glu 
                245                 250                 255     


Ser Glu Gly Ile Phe Arg Leu Ser Gly Cys Xaa Ala Lys Val Lys Gln 
            260                 265                 270         


Tyr Arg Glu Glu Leu Asp Ala Lys Phe Asn Ala Asp Lys Phe Lys Trp 
        275                 280                 285             


Asp Lys Met Cys His Arg Glu Ala Ala Val Met Leu Lys Ala Phe Phe 
    290                 295                 300                 


Arg Glu Leu Pro Xaa Ser Leu Phe Pro Val Glu Tyr Ile Pro Ala Phe 
305                 310                 315                 320 


Ile Ser Leu Met Glu Arg Gly Pro His Val Lys Val Gln Phe Gln Ala 
                325                 330                 335     


Leu His Leu Met Val Met Ala Leu Pro Asp Ala Asn Arg Asp Ala Ala 
            340                 345                 350         


Gln Ala Leu Met Xaa Phe Phe Asn Lys Val Ile Ala Asn Glu Ser Lys 
        355                 360                 365             


Asn Arg Met Ser Leu Trp Asn Ile Ser Xaa Val Met Ala Pro Asn Leu 
    370                 375                 380                 


Phe Phe Ser Arg Ser Lys His Ser Asp Tyr Glu Glu Leu Leu Leu Ala 
385                 390                 395                 400 


Asn Xaa Ala Ala His Ile Ile Arg Leu Met Leu Lys Tyr Gln Lys Ile 
                405                 410                 415     


Leu Trp Lys Val Pro Ser Phe Leu Ile Xaa Gln Val Arg Arg Met Asn 
            420                 425                 430         


Glu Ala Xaa Met Leu Leu Lys Lys Gln Leu Pro Ser Val Arg Lys Leu 
        435                 440                 445             


Leu Arg Arg Lys Xaa Leu Glu Arg Glu Xaa Ala Ser Pro Lys Xaa Ser 
    450                 455                 460                 


Lys Val Leu Gln Lys Ser Pro Ser Ala Arg Arg Met Ser Asp Val Pro 
465                 470                 475                 480 


Glu Gly Val Ile Arg Val His Ala Pro Leu Leu Ser Lys Val Ser Met 
                485                 490                 495     


Ala Ile Gln Leu Asn Asn Gln Xaa Lys Ala Lys Asp Ile Leu Ala Lys 
            500                 505                 510         


Phe Gln Tyr Glu Asn Ser His Gly Ser Ser Glu Cys Ile Lys Ile Gln 
        515                 520                 525             


Asn Gln Arg Leu Tyr Glu Ile Gly Gly Asn Ile Gly Glu His Cys Leu 
    530                 535                 540                 


Asp Pro Asp Ala Tyr Ile Leu Asp Val Tyr Arg Ile Asn Pro Gln Ala 
545                 550                 555                 560 


Glu Trp Val Ile Lys Pro Gln Gln Ser Ser 
                565                 570 


<210> 2821
<211> 57
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<400> 2821
Met Arg Lys Lys Asp Lys Gln Ser Ile Arg Asp Val Arg Asp Ile Phe 
1               5                   10                  15      


Gly Val Ser Glu Ser Pro Pro Arg Asp Xaa Cys Gly Asn His Xaa Asn 
            20                  25                  30          


Gln Leu Asp Gly Xaa Lys Glu Glu Arg Glu Leu Pro Arg Val Ile Lys 
        35                  40                  45              


Xaa Ser Gly Ser Met Tyr Tyr Pro Val 
    50                  55          


<210> 2822
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 2822
Met Ser Glu Pro Gly Val Leu Cys Ile Val Phe Asp Trp Arg Lys Ser 
1               5                   10                  15      


Ile Pro Arg Cys Arg Arg Ile Asn Arg Met Leu Ser Asn Glu Ser Leu 
            20                  25                  30          


His Pro Pro Ala Phe Ser Arg Ser Asn Ser Glu Ala Ser Val Asp Ser 
        35                  40                  45              


Ala Ser Met Glu Asp Phe Trp Arg Glu Ile Glu Ser Asp Glu Glu Glu 
    50                  55                  60                  


Asp Gly Lys Ala Leu Leu Ser Xaa Leu Xaa Arg Xaa Gln Ala Ala Ala 
65                  70                  75                  80  


Val Gln Lys Arg Tyr His Xaa Tyr Xaa Gln Xaa Met Arg Lys Lys Asp 
                85                  90                  95      


Lys Gln Ser Ile Arg Asp Val Arg Asp Ile Phe Gly Val Ser Glu Ser 
            100                 105                 110         


Pro Pro Arg Asp Xaa Cys Gly Asn His Xaa Asn Gln Leu Asp Gly Xaa 
        115                 120                 125             


Lys Glu Glu Arg Glu Leu Pro Arg Val 
    130                 135         


<210> 2823
<211> 393
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<400> 2823
Met Ile Ala His Lys Gln Lys Lys Xaa Lys Lys Lys Arg Ala Trp Ala 
1               5                   10                  15      


Ser Gly Gln Leu Ser Xaa Asp Ile Xaa Xaa Ser Glu Met Gly Leu Lys 
            20                  25                  30          


Ser Leu Ser Ser Asn Ser Ile Phe Asp Pro Asp Tyr Ile Lys Glu Leu 
        35                  40                  45              


Val Asn Asp Ile Arg Lys Phe Ser His Met Leu Leu Tyr Leu Lys Glu 
    50                  55                  60                  


Ala Ile Phe Ser Asp Cys Phe Lys Glu Val Ile His Ile Arg Leu Glu 
65                  70                  75                  80  


Glu Leu Leu Arg Val Leu Lys Ser Ile Met Asn Lys His Gln Asn Leu 
                85                  90                  95      


Asn Ser Val Asp Leu Gln Asn Ala Ala Glu Met Leu Xaa Ala Lys Val 
            100                 105                 110         


Lys Ala Val Asn Phe Xaa Glu Val Asn Glu Glu Asn Lys Asn Asp Leu 
        115                 120                 125             


Phe Gln Glu Val Phe Ser Ser Ile Glu Xaa Leu Ala Phe Xaa Phe Gly 
    130                 135                 140                 


Asn Ile Leu Xaa Asn Phe Leu Met Gly Asp Val Gly Asn Asp Ser Leu 
145                 150                 155                 160 


Leu Arg Leu Pro Val Ser Arg Glu Xaa Lys Ser Phe Glu Asn Val Ser 
                165                 170                 175     


Val Glu Ser Val Asp Ser Ser Ser Glu Lys Gly Asn Phe Ser Pro Leu 
            180                 185                 190         


Glu Leu Asp Asn Val Leu Leu Lys Asn Xaa Asp Ser Ile Glu Leu Ala 
        195                 200                 205             


Leu Ser Tyr Ala Lys Xaa Trp Ser Lys Tyr Xaa Lys Asn Ile Val Ser 
    210                 215                 220                 


Trp Val Glu Lys Lys Leu Asn Leu Glu Leu Glu Ser Xaa Arg Asn Met 
225                 230                 235                 240 


Val Lys Leu Ala Glu Ala Xaa Arg Xaa Asn Ile Gly Ile Gln Glu Phe 
                245                 250                 255     


Met Pro Leu Gln Ser Leu Phe Xaa Asn Ala Leu Leu Asn Asp Ile Glu 
            260                 265                 270         


Ser Ser His Leu Leu Gln Gln Xaa Ile Ala Ala Leu Gln Ala Asn Lys 
        275                 280                 285             


Phe Val Gln Pro Leu Leu Gly Arg Lys Asn Glu Met Glu Lys Gln Arg 
    290                 295                 300                 


Lys Glu Ile Lys Glu Leu Trp Lys Gln Glu Gln Asn Lys Met Leu Glu 
305                 310                 315                 320 


Ala Glu Asn Ala Leu Lys Lys Ala Lys Leu Leu Cys Met Gln Arg Gln 
                325                 330                 335     


Asp Glu Tyr Glu Lys Ala Lys Ser Ser Met Phe Arg Ala Glu Glu Glu 
            340                 345                 350         


His Leu Ser Ser Ser Gly Gly Leu Ala Lys Asn Leu Asn Lys Gln Leu 
        355                 360                 365             


Glu Lys Lys Arg Arg Leu Glu Glu Glu Ala Leu Gln Lys Val Xaa Ile 
    370                 375                 380                 


Phe Phe Phe Phe Ile Cys Lys Leu Asn 
385                 390             


<210> 2824
<211> 1035
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<400> 2824
Met Ile Ala His Lys Gln Lys Lys Xaa Lys Lys Lys Arg Ala Trp Ala 
1               5                   10                  15      


Ser Gly Gln Leu Ser Xaa Asp Ile Xaa Xaa Ser Glu Met Gly Leu Lys 
            20                  25                  30          


Ser Leu Ser Ser Asn Ser Ile Phe Asp Pro Asp Tyr Ile Lys Glu Leu 
        35                  40                  45              


Val Asn Asp Ile Arg Lys Phe Ser His Met Leu Leu Tyr Leu Lys Glu 
    50                  55                  60                  


Ala Ile Phe Ser Asp Cys Phe Lys Glu Val Ile His Ile Arg Leu Glu 
65                  70                  75                  80  


Glu Leu Leu Arg Val Leu Lys Ser Ile Met Asn Lys His Gln Asn Leu 
                85                  90                  95      


Asn Ser Val Asp Leu Gln Asn Ala Ala Glu Met Leu Xaa Ala Lys Val 
            100                 105                 110         


Lys Ala Val Asn Phe Xaa Glu Val Asn Glu Glu Asn Lys Asn Asp Leu 
        115                 120                 125             


Phe Gln Glu Val Phe Ser Ser Ile Glu Xaa Leu Ala Phe Xaa Phe Gly 
    130                 135                 140                 


Asn Ile Leu Xaa Asn Phe Leu Met Gly Asp Val Gly Asn Asp Ser Leu 
145                 150                 155                 160 


Leu Arg Leu Pro Val Ser Arg Glu Xaa Lys Ser Phe Glu Asn Val Ser 
                165                 170                 175     


Val Glu Ser Val Asp Ser Ser Ser Glu Lys Gly Asn Phe Ser Pro Leu 
            180                 185                 190         


Glu Leu Asp Asn Val Leu Leu Lys Asn Xaa Asp Ser Ile Glu Leu Ala 
        195                 200                 205             


Leu Ser Tyr Ala Lys Xaa Trp Ser Lys Tyr Xaa Lys Asn Ile Val Ser 
    210                 215                 220                 


Trp Val Glu Lys Lys Leu Asn Leu Glu Leu Glu Ser Xaa Arg Asn Met 
225                 230                 235                 240 


Val Lys Leu Ala Glu Ala Xaa Arg Xaa Asn Ile Gly Ile Gln Glu Phe 
                245                 250                 255     


Met Pro Leu Gln Ser Leu Phe Xaa Asn Ala Leu Leu Asn Asp Ile Glu 
            260                 265                 270         


Ser Ser His Leu Leu Gln Gln Xaa Ile Ala Ala Leu Gln Ala Asn Lys 
        275                 280                 285             


Phe Val Gln Pro Leu Leu Gly Arg Lys Asn Glu Met Glu Lys Gln Arg 
    290                 295                 300                 


Lys Glu Ile Lys Glu Leu Trp Lys Gln Glu Gln Asn Lys Met Leu Glu 
305                 310                 315                 320 


Ala Glu Asn Ala Leu Lys Lys Ala Lys Leu Leu Cys Met Gln Arg Gln 
                325                 330                 335     


Asp Glu Tyr Glu Lys Ala Lys Ser Ser Met Phe Arg Ala Glu Glu Glu 
            340                 345                 350         


His Leu Ser Ser Ser Gly Gly Leu Ala Lys Asn Leu Asn Lys Gln Leu 
        355                 360                 365             


Glu Lys Lys Arg Arg Leu Glu Glu Glu Ala Leu Gln Lys Val Glu Glu 
    370                 375                 380                 


Ala Asn Glu Leu Tyr Lys Val Cys Val Xaa Asn Val Glu Glu Arg Arg 
385                 390                 395                 400 


Asn Asp Leu Glu Asn Xaa Lys Arg Glu Ile Leu Ala Gln Leu Arg Xaa 
                405                 410                 415     


Leu Val Phe Gln Cys Asp Leu Xaa Leu Lys Ala Val Xaa Val Asn Leu 
            420                 425                 430         


Phe His Met Gln His Leu Gln Ala Ala Ser Leu Ala Asp Ser Leu Gln 
        435                 440                 445             


Ser Leu Cys Asp Ser Ala Lys Leu Tyr Asp Pro Gly Gln Glu Tyr Ser 
    450                 455                 460                 


Glu Phe Val Lys Ala Xaa Asn Ser Xaa Glu Glu Glu Lys Val Asp Gly 
465                 470                 475                 480 


Asn Val Asn Lys His Leu Asn Ser Ser Gln Pro Ser Gly Phe Gly Pro 
                485                 490                 495     


Ala Asn Ser Leu Glu Asp Val Val Arg Leu Pro Asp Ser Ser Asn Lys 
            500                 505                 510         


Ile Glu Glu Asp Arg Cys Ser Asn Ser Ala Asp Ile Xaa Gly Pro Ser 
        515                 520                 525             


Phe Ile Arg Ser Trp Xaa Phe Gly Met Phe Ser Asp Ser Glu Ser Xaa 
    530                 535                 540                 


Gly Gly Ser Ser Glu Ser Arg Ser Leu Asp Ser Glu Ser Ile Ser Pro 
545                 550                 555                 560 


Gly Asp Phe His Arg Lys Leu Pro Arg Xaa Pro Ser Ser Gly Xaa Met 
                565                 570                 575     


Ser Ser Ala Asp Asp Leu Asp Glu Arg Glu Pro Pro Ser Pro Ser Glu 
            580                 585                 590         


Xaa Gly Pro Asn Ser Leu Gly Xaa Phe Lys Lys Xaa Leu Met Ser Lys 
        595                 600                 605             


Ala Ala Leu Xaa His Lys Phe Arg Lys Leu Arg Ser Pro Xaa Lys Cys 
    610                 615                 620                 


Arg Asp Cys Glu Gly Ile Val Val Phe Gln Gly Val Glu Cys Glu Glu 
625                 630                 635                 640 


Cys Leu Leu Val Cys His Arg Lys Cys Leu Glu Asn Leu Val Ile Ile 
                645                 650                 655     


Cys Gly His Gln Lys Leu Pro Gly Lys Ile His Leu Phe Gly Ala Glu 
            660                 665                 670         


Phe Xaa Gln Val Ala Lys Lys Glu Pro Asp Gly Ile Pro Phe Ile Leu 
        675                 680                 685             


Lys Ile Cys Ala Ser Glu Ile Glu Asn Arg Ala Leu Cys Leu Gln Gly 
    690                 695                 700                 


Ile Tyr Arg Val Cys Gly Asn Lys Ile Lys Xaa Glu Lys Leu Cys Gln 
705                 710                 715                 720 


Ala Leu Glu Asn Gly Met His Leu Val Asp Ile Ser Glu Phe Ser Ser 
                725                 730                 735     


His Asp Ile Cys Asp Val Leu Lys Leu Tyr Leu Arg Gln Leu Pro Glu 
            740                 745                 750         


Pro Phe Ile Leu Phe Arg Leu Tyr Lys Glu Phe Ile Asp Leu Ala Lys 
        755                 760                 765             


Glu Ile Gln His Val Asn Glu Glu Gln Glu Xaa Lys Lys Asn Ser Leu 
    770                 775                 780                 


Glu Asp Lys Lys Trp Pro Asn Met Cys Ile Glu Ile Asn Arg Ile Leu 
785                 790                 795                 800 


Leu Lys Ser Lys Asp Leu Leu Arg Gln Leu Pro Ala Ser Asn Phe Asn 
                805                 810                 815     


Ser Leu His Phe Leu Ile Val His Leu Lys Arg Val Val Asp His Ala 
            820                 825                 830         


Glu Glu Asn Lys Met Asn Ser Lys Asn Leu Gly Val Ile Phe Gly Pro 
        835                 840                 845             


Ser Leu Ile Arg Pro Arg Pro Xaa Xaa Ala Pro Ile Xaa Ile Ser Ser 
    850                 855                 860                 


Leu Ala Glu Tyr Ser Asn Gln Ala Arg Leu Val Glu Phe Leu Ile Xaa 
865                 870                 875                 880 


Tyr Ser Gln Lys Ile Phe Asp Gly Ser Leu Gln Pro Gln Asp Val Met 
                885                 890                 895     


Cys Ser Ile Gly Val Val Asp Gln Gly Cys Phe Pro Lys Pro Leu Leu 
            900                 905                 910         


Ser Pro Glu Glu Arg Asp Ile Glu Arg Ser Met Lys Ser Leu Phe Phe 
        915                 920                 925             


Ser Ser Lys Glu Asp Ile His Xaa Ser Glu Ser Glu Ser Lys Ile Phe 
    930                 935                 940                 


Glu Arg Ala Xaa Ser Phe Glu Glu Ser Glu Arg Lys Gln Asn Ala Leu 
945                 950                 955                 960 


Gly Lys Cys Asp Ala Cys Leu Ser Asp Lys Ala Gln Leu Leu Leu Asp 
                965                 970                 975     


Gln Glu Ala Glu Ser Ala Ser Gln Lys Ile Glu Asp Gly Lys Xaa Pro 
            980                 985                 990         


Lys Pro Leu Ser Leu Lys Ser Asp  Arg Ser Xaa Asn Asn  Val Glu Arg 
        995                 1000                 1005             


His Xaa  Pro Arg Xaa Lys Ile  Arg Pro Glu Xaa Leu  Ile Gln Asn 
    1010                 1015                 1020             


Tyr Arg  Val Leu His Leu Gln  Tyr Val Phe Cys Cys  
    1025                 1030                 1035 


<210> 2825
<211> 1261
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1091)..(1091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1108)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<400> 2825
Met Ile Ala His Lys Gln Lys Lys Xaa Lys Lys Lys Arg Ala Trp Ala 
1               5                   10                  15      


Ser Gly Gln Leu Ser Xaa Asp Ile Xaa Xaa Ser Glu Met Gly Leu Lys 
            20                  25                  30          


Ser Leu Ser Ser Asn Ser Ile Phe Asp Pro Asp Tyr Ile Lys Glu Leu 
        35                  40                  45              


Val Asn Asp Ile Arg Lys Phe Ser His Met Leu Leu Tyr Leu Lys Glu 
    50                  55                  60                  


Ala Ile Phe Ser Asp Cys Phe Lys Glu Val Ile His Ile Arg Leu Glu 
65                  70                  75                  80  


Glu Leu Leu Arg Val Leu Lys Ser Ile Met Asn Lys His Gln Asn Leu 
                85                  90                  95      


Asn Ser Val Asp Leu Gln Asn Ala Ala Glu Met Leu Xaa Ala Lys Val 
            100                 105                 110         


Lys Ala Val Asn Phe Xaa Glu Val Asn Glu Glu Asn Lys Asn Asp Leu 
        115                 120                 125             


Phe Gln Glu Val Phe Ser Ser Ile Glu Xaa Leu Ala Phe Xaa Phe Gly 
    130                 135                 140                 


Asn Ile Leu Xaa Asn Phe Leu Met Gly Asp Val Gly Asn Asp Ser Leu 
145                 150                 155                 160 


Leu Arg Leu Pro Val Ser Arg Glu Xaa Lys Ser Phe Glu Asn Val Ser 
                165                 170                 175     


Val Glu Ser Val Asp Ser Ser Ser Glu Lys Gly Asn Phe Ser Pro Leu 
            180                 185                 190         


Glu Leu Asp Asn Val Leu Leu Lys Asn Xaa Asp Ser Ile Glu Leu Ala 
        195                 200                 205             


Leu Ser Tyr Ala Lys Xaa Trp Ser Lys Tyr Xaa Lys Asn Ile Val Ser 
    210                 215                 220                 


Trp Val Glu Lys Lys Leu Asn Leu Glu Leu Glu Ser Xaa Arg Asn Met 
225                 230                 235                 240 


Val Lys Leu Ala Glu Ala Xaa Arg Xaa Asn Ile Gly Ile Gln Glu Phe 
                245                 250                 255     


Met Pro Leu Gln Ser Leu Phe Xaa Asn Ala Leu Leu Asn Asp Ile Glu 
            260                 265                 270         


Ser Ser His Leu Leu Gln Gln Xaa Ile Ala Ala Leu Gln Ala Asn Lys 
        275                 280                 285             


Phe Val Gln Pro Leu Leu Gly Arg Lys Asn Glu Met Glu Lys Gln Arg 
    290                 295                 300                 


Lys Glu Ile Lys Glu Leu Trp Lys Gln Glu Gln Asn Lys Met Leu Glu 
305                 310                 315                 320 


Ala Glu Asn Ala Leu Lys Lys Ala Lys Leu Leu Cys Met Gln Arg Gln 
                325                 330                 335     


Asp Glu Tyr Glu Lys Ala Lys Ser Ser Met Phe Arg Ala Glu Glu Glu 
            340                 345                 350         


His Leu Ser Ser Ser Gly Gly Leu Ala Lys Asn Leu Asn Lys Gln Leu 
        355                 360                 365             


Glu Lys Lys Arg Arg Leu Glu Glu Glu Ala Leu Gln Lys Val Glu Glu 
    370                 375                 380                 


Ala Asn Glu Leu Tyr Lys Val Cys Val Xaa Asn Val Glu Glu Arg Arg 
385                 390                 395                 400 


Asn Asp Leu Glu Asn Xaa Lys Arg Glu Ile Leu Ala Gln Leu Arg Xaa 
                405                 410                 415     


Leu Val Phe Gln Cys Asp Leu Xaa Leu Lys Ala Val Xaa Val Asn Leu 
            420                 425                 430         


Phe His Met Gln His Leu Gln Ala Ala Ser Leu Ala Asp Ser Leu Gln 
        435                 440                 445             


Ser Leu Cys Asp Ser Ala Lys Leu Tyr Asp Pro Gly Gln Glu Tyr Ser 
    450                 455                 460                 


Glu Phe Val Lys Ala Xaa Asn Ser Xaa Glu Glu Glu Lys Val Asp Gly 
465                 470                 475                 480 


Asn Val Asn Lys His Leu Asn Ser Ser Gln Pro Ser Gly Phe Gly Pro 
                485                 490                 495     


Ala Asn Ser Leu Glu Asp Val Val Arg Leu Pro Asp Ser Ser Asn Lys 
            500                 505                 510         


Ile Glu Glu Asp Arg Cys Ser Asn Ser Ala Asp Ile Xaa Gly Pro Ser 
        515                 520                 525             


Phe Ile Arg Ser Trp Xaa Phe Gly Met Phe Ser Asp Ser Glu Ser Xaa 
    530                 535                 540                 


Gly Gly Ser Ser Glu Ser Arg Ser Leu Asp Ser Glu Ser Ile Ser Pro 
545                 550                 555                 560 


Gly Asp Phe His Arg Lys Leu Pro Arg Xaa Pro Ser Ser Gly Xaa Met 
                565                 570                 575     


Ser Ser Ala Asp Asp Leu Asp Glu Arg Glu Pro Pro Ser Pro Ser Glu 
            580                 585                 590         


Xaa Gly Pro Asn Ser Leu Gly Xaa Phe Lys Lys Xaa Leu Met Ser Lys 
        595                 600                 605             


Ala Ala Leu Xaa His Lys Phe Arg Lys Leu Arg Ser Pro Xaa Lys Cys 
    610                 615                 620                 


Arg Asp Cys Glu Gly Ile Val Val Phe Gln Gly Val Glu Cys Glu Glu 
625                 630                 635                 640 


Cys Leu Leu Val Cys His Arg Lys Cys Leu Glu Asn Leu Val Ile Ile 
                645                 650                 655     


Cys Gly His Gln Lys Leu Pro Gly Lys Ile His Leu Phe Gly Ala Glu 
            660                 665                 670         


Phe Xaa Gln Val Ala Lys Lys Glu Pro Asp Gly Ile Pro Phe Ile Leu 
        675                 680                 685             


Lys Ile Cys Ala Ser Glu Ile Glu Asn Arg Ala Leu Cys Leu Gln Gly 
    690                 695                 700                 


Ile Tyr Arg Val Cys Gly Asn Lys Ile Lys Xaa Glu Lys Leu Cys Gln 
705                 710                 715                 720 


Ala Leu Glu Asn Gly Met His Leu Val Asp Ile Ser Glu Phe Ser Ser 
                725                 730                 735     


His Asp Ile Cys Asp Val Leu Lys Leu Tyr Leu Arg Gln Leu Pro Glu 
            740                 745                 750         


Pro Phe Ile Leu Phe Arg Leu Tyr Lys Glu Phe Ile Asp Leu Ala Lys 
        755                 760                 765             


Glu Ile Gln His Val Asn Glu Glu Gln Glu Xaa Lys Lys Asn Ser Leu 
    770                 775                 780                 


Glu Asp Lys Lys Trp Pro Asn Met Cys Ile Glu Ile Asn Arg Ile Leu 
785                 790                 795                 800 


Leu Lys Ser Lys Asp Leu Leu Arg Gln Leu Pro Ala Ser Asn Phe Asn 
                805                 810                 815     


Ser Leu His Phe Leu Ile Val His Leu Lys Arg Val Val Asp His Ala 
            820                 825                 830         


Glu Glu Asn Lys Met Asn Ser Lys Asn Leu Gly Val Ile Phe Gly Pro 
        835                 840                 845             


Ser Leu Ile Arg Pro Arg Pro Xaa Xaa Ala Pro Ile Xaa Ile Ser Ser 
    850                 855                 860                 


Leu Ala Glu Tyr Ser Asn Gln Ala Arg Leu Val Glu Phe Leu Ile Xaa 
865                 870                 875                 880 


Tyr Ser Gln Lys Ile Phe Asp Gly Ser Leu Gln Pro Gln Asp Val Met 
                885                 890                 895     


Cys Ser Ile Gly Val Val Asp Gln Gly Cys Phe Pro Lys Pro Leu Leu 
            900                 905                 910         


Ser Pro Glu Glu Arg Asp Ile Glu Arg Ser Met Lys Ser Leu Phe Phe 
        915                 920                 925             


Ser Ser Lys Glu Asp Ile His Xaa Ser Glu Ser Glu Ser Lys Ile Phe 
    930                 935                 940                 


Glu Arg Ala Xaa Ser Phe Glu Glu Ser Glu Arg Lys Gln Asn Ala Leu 
945                 950                 955                 960 


Gly Lys Cys Asp Ala Cys Leu Ser Asp Lys Ala Gln Leu Leu Leu Asp 
                965                 970                 975     


Gln Glu Ala Glu Ser Ala Ser Gln Lys Ile Glu Asp Gly Lys Xaa Pro 
            980                 985                 990         


Lys Pro Leu Ser Leu Lys Ser Asp  Arg Ser Xaa Asn Asn  Val Glu Arg 
        995                 1000                 1005             


His Xaa  Pro Arg Xaa Lys Ile  Arg Pro Val Ser Leu  Pro Val Asp 
    1010                 1015                 1020             


Arg Leu  Leu Leu Ala Ser Pro  Pro Asn Glu Arg Asn  Gly Arg Asn 
    1025                 1030                 1035             


Met Gly  Asn Val Asn Leu Asp  Lys Phe Cys Lys Asn  Pro Ala Phe 
    1040                 1045                 1050             


Glu Gly  Val Asn Arg Lys Asp  Ala Ala Xaa Xaa Val  Cys Ser Lys 
    1055                 1060                 1065             


Phe Asn  Gly Phe Asp Gln Gln  Xaa Leu Gln Lys Ile  Gln Asp Lys 
    1070                 1075                 1080             


Gln Tyr  Glu Gln Asn Ser Leu  Xaa Ala Lys Xaa Xaa  Met Ile Met 
    1085                 1090                 1095             


Pro Ser  Ala Leu Gln Glu Lys  Gly Val Xaa Xaa Ser  Leu Gln Ile 
    1100                 1105                 1110             


Ser Gly  Asp His Ser Ile Asn  Ala Xaa Gln Pro Ser  Lys Pro Tyr 
    1115                 1120                 1125             


Ala Glu  Pro Val Arg Ser Val  Arg Glu Ala Ser Glu  Arg Arg Ser 
    1130                 1135                 1140             


Ser Asp  Ser Tyr Pro Leu Ala  Pro Val Arg Ala Pro  Arg Xaa Leu 
    1145                 1150                 1155             


Gln Pro  Gln His Trp Xaa Xaa  Phe Tyr Lys Pro His  Ala Pro Ile 
    1160                 1165                 1170             


Ile Ser  Ile Arg Gly Asn Glu  Glu Lys Pro Ala Ser  Pro Ser Ala 
    1175                 1180                 1185             


Ala Val  Pro Pro Gly Xaa Asp  His Asp Pro His Gly  Leu Val Val 
    1190                 1195                 1200             


Lys Ser  Met Pro Asp Pro Asp  Lys Ala Ser Ala Cys  Pro Gly Gln 
    1205                 1210                 1215             


Ala Xaa  Gly Gln Pro Lys Glu  Asp Ser Glu Glu Leu  Gly Leu Pro 
    1220                 1225                 1230             


Asp Val  Asn Pro Met Cys Gln  Arg Pro Arg Leu Lys  Arg Met Gln 
    1235                 1240                 1245             


Gln Phe  Glu Asp Leu Glu Gly  Glu Ile Pro Gln Phe  Val 
    1250                 1255                 1260     


<210> 2826
<211> 924
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(914)
<223> Selenocysteine

<400> 2826
Met Lys Ser Lys Asp Ile Glu Ala Ser Gly Phe Asn Gly Xaa Ala Ala 
1               5                   10                  15      


Phe Met Glu Val Arg Val Gln Ser Ile Val Val Glu Phe Ile Leu Xaa 
            20                  25                  30          


His Val Asp Gln Leu Phe Gly Gly Ala Ala Leu Ser Gly Gly Glu Val 
        35                  40                  45              


Glu Ser Gly Trp Arg Ser Leu Pro Gly Xaa Arg Ala Ser Gly Ser Pro 
    50                  55                  60                  


Glu Asp Leu Met Pro Arg Pro Leu Pro Tyr His Leu Pro Ser Ile Leu 
65                  70                  75                  80  


Gln Ala Gly Asp Gly Pro Pro Gln Met Arg Pro Tyr His Xaa Ile Ile 
                85                  90                  95      


Glu Ile Ala Glu His Lys Arg Lys Gly Ser Leu Lys Val Arg Lys Trp 
            100                 105                 110         


Arg Ser Ile Phe Asn Leu Gly Arg Ser Gly His Glu Xaa Lys Arg Lys 
        115                 120                 125             


Leu Pro Arg Gly Ala Glu Asp Arg Glu Asp Lys Ser Asn Lys Gly Xaa 
    130                 135                 140                 


Leu Arg Pro Ala Lys Ser Met Asp Ser Leu Ser Ala Ala Ala Gly Ala 
145                 150                 155                 160 


Ser Asp Glu Pro Glu Gly Leu Val Gly Pro Ser Ser Pro Arg Pro Ser 
                165                 170                 175     


Pro Leu Leu Pro Glu Ser Leu Glu Asn Asp Ser Ile Glu Ala Ala Glu 
            180                 185                 190         


Gly Glu Gln Glu Pro Glu Ala Glu Ala Leu Gly Gly Xaa Asn Ser Glu 
        195                 200                 205             


Pro Gly Xaa Pro Arg Ala Gly Arg Ser Ala Ile Arg Ala Gly Gly Ser 
    210                 215                 220                 


Ser Arg Ala Glu Arg Cys Ala Gly Val His Ile Ser Asp Pro Tyr Asn 
225                 230                 235                 240 


Val Asn Leu Pro Leu His Ile Xaa Ser Ile Leu Ser Val Pro Pro Asn 
                245                 250                 255     


Ile Ile Ser Asn Val Ser Leu Ala Arg Leu Xaa Arg Gly Leu Glu Cys 
            260                 265                 270         


Pro Ala Leu Gln His Arg Pro Ser Pro Ala Ser Gly Pro Gly Pro Gly 
        275                 280                 285             


Pro Gly Leu Gly Pro Gly Pro Pro Asp Glu Lys Leu Glu Ala Ser Pro 
    290                 295                 300                 


Ala Ser Ser Pro Leu Ala Asp Ser Gly Pro Asp Asp Leu Ala Pro Ala 
305                 310                 315                 320 


Leu Glu Asp Ser Leu Ser Gln Glu Val Gln Asp Ser Phe Ser Phe Leu 
                325                 330                 335     


Glu Asp Ser Ser Ser Ser Glu Pro Glu Trp Val Gly Ala Glu Asp Gly 
            340                 345                 350         


Glu Val Ala Gln Ala Glu Ala Ala Gly Ala Ala Phe Ser Pro Gly Glu 
        355                 360                 365             


Asp Asp Pro Gly Met Gly Tyr Leu Glu Glu Leu Leu Gly Val Gly Pro 
    370                 375                 380                 


Gln Val Glu Glu Phe Ser Val Glu Pro Pro Leu Asp Asp Leu Ser Leu 
385                 390                 395                 400 


Asp Glu Ala Gln Phe Val Leu Ala Pro Ser Cys Cys Ser Leu Asp Ser 
                405                 410                 415     


Ala Gly Pro Arg Pro Glu Val Glu Glu Glu Asn Gly Glu Glu Val Phe 
            420                 425                 430         


Leu Ser Ala Tyr Asp Asp Leu Ser Pro Leu Leu Gly Pro Lys Pro Pro 
        435                 440                 445             


Ile Trp Lys Gly Ser Gly Ser Leu Glu Gly Glu Ala Ala Gly Cys Gly 
    450                 455                 460                 


Arg Gln Ala Leu Gly Gln Gly Gly Glu Glu Gln Ala Cys Trp Glu Val 
465                 470                 475                 480 


Gly Glu Asp Lys Gln Ala Glu Pro Gly Gly Arg Leu Asp Ile Arg Glu 
                485                 490                 495     


Glu Ala Glu Gly Ser Pro Glu Xaa Lys Val Glu Ala Gly Lys Ala Ser 
            500                 505                 510         


Glu Asp Arg Gly Glu Ala Gly Gly Ser Gln Glu Xaa Lys Val Arg Leu 
        515                 520                 525             


Arg Glu Gly Ser Arg Glu Glu Xaa Glu Ala Lys Glu Glu Lys Ser Lys 
    530                 535                 540                 


Gly Gln Lys Lys Ala Asp Ser Met Glu Ala Lys Gly Val Glu Glu Pro 
545                 550                 555                 560 


Gly Gly Asp Glu Tyr Xaa Asp Glu Lys Glu Lys Glu Ile Glu Arg Glu 
                565                 570                 575     


Glu Asp Glu Gln Arg Glu Glu Ala Gln Val Glu Ala Gly Arg Asp Leu 
            580                 585                 590         


Glu Gln Gly Ala Gln Glu Asp Gln Val Ala Glu Glu Lys Trp Glu Val 
        595                 600                 605             


Val Gln Lys Gln Glu Ala Glu Gly Val Arg Glu Asp Glu Asp Lys Gly 
    610                 615                 620                 


Gln Arg Glu Lys Gly Tyr His Glu Ala Arg Lys Asp Gln Gly Asp Gly 
625                 630                 635                 640 


Glu Asp Ser Arg Ser Pro Glu Ala Ala Xaa Glu Gly Gly Ala Gly Glu 
                645                 650                 655     


Val Ser Lys Glu Arg Glu Ser Gly Asp Gly Glu Ala Glu Gly Asp Gln 
            660                 665                 670         


Arg Ala Gly Gly Tyr Tyr Leu Glu Glu Asp Xaa Leu Ser Glu Gly Ser 
        675                 680                 685             


Gly Val Ala Ser Leu Glu Val Asp Cys Ala Lys Glu Gly Asn Pro His 
    690                 695                 700                 


Ser Ser Glu Met Glu Glu Val Ala Pro Gln Pro Pro Gln Pro Glu Glu 
705                 710                 715                 720 


Met Glu Pro Glu Gly Gln Pro Ser Pro Asp Gly Cys Leu Cys Pro Cys 
                725                 730                 735     


Ser Leu Gly Leu Gly Gly Val Gly Met Arg Leu Ala Ser Xaa Leu Val 
            740                 745                 750         


Gln Val Gln Gln Val Arg Ser Val Pro Val Val Pro Pro Lys Pro Gln 
        755                 760                 765             


Phe Ala Lys Met Pro Ser Ala Met Cys Ser Lys Ile His Val Ala Pro 
    770                 775                 780                 


Ala Asn Pro Cys Pro Arg Pro Gly Arg Leu Asp Gly Xaa Pro Gly Glu 
785                 790                 795                 800 


Arg Ala Trp Gly Ser Arg Ala Ser Arg Ser Ser Trp Arg Asn Gly Gly 
                805                 810                 815     


Ser Leu Ser Phe Asp Ala Ala Val Ala Leu Ala Arg Asp Arg Gln Arg 
            820                 825                 830         


Xaa Glu Ala Gln Gly Val Arg Arg Xaa Gln Xaa Cys Xaa Glu Gly Gly 
        835                 840                 845             


Asp Tyr Cys Leu Ile Pro Arg Xaa Ser Pro Cys Ser Met Ile Ser Ala 
    850                 855                 860                 


His Ser Pro Arg Pro Leu Ser Cys Leu Glu Leu Pro Ser Glu Gly Ala 
865                 870                 875                 880 


Glu Gly Ser Gly Ser Arg Ser Arg Leu Ser Leu Pro Pro Arg Glu Pro 
                885                 890                 895     


Gln Val Pro Asp Pro Leu Leu Ser Ser Gln Arg Arg Ser Tyr Ala Phe 
            900                 905                 910         


Glu Xaa Gln Ala Asn Pro Gly Lys Gly Glu Gly Leu 
        915                 920                 


<210> 2827
<211> 41
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<400> 2827
Met Lys Ser Arg Gln Lys Gly Lys Lys Lys Gly Ser Ala Lys Glu Arg 
1               5                   10                  15      


Val Phe Gly Cys Asp Leu Gln Glu His Leu Gln His Ser Gly Gln Glu 
            20                  25                  30          


Gly Gly Cys Arg Ser Ala Ile Gly Xaa 
        35                  40      


<210> 2828
<211> 63
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<400> 2828
Met Lys Ser Arg Gln Lys Gly Lys Lys Lys Gly Ser Ala Lys Glu Arg 
1               5                   10                  15      


Val Phe Gly Cys Asp Leu Gln Glu His Leu Gln His Ser Gly Gln Glu 
            20                  25                  30          


Gly Ser His Ser Val Xaa Gln Gln Ala Arg Val Arg Leu Pro Ala Ala 
        35                  40                  45              


Leu Ala Ser Trp Ala Gln Val Ile Leu Pro Tyr Gln Pro Pro Glu 
    50                  55                  60              


<210> 2829
<211> 890
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<400> 2829
Met Lys Ser Arg Gln Lys Gly Lys Lys Lys Gly Ser Ala Lys Glu Arg 
1               5                   10                  15      


Val Phe Gly Cys Asp Leu Gln Glu His Leu Gln His Ser Gly Gln Glu 
            20                  25                  30          


Val Pro Gln Val Leu Lys Ser Cys Ala Glu Phe Val Glu Glu Tyr Gly 
        35                  40                  45              


Val Val Asp Gly Ile Tyr Arg Leu Ser Gly Val Ser Ser Asn Ile Gln 
    50                  55                  60                  


Lys Leu Arg Gln Glu Phe Glu Ser Glu Arg Lys Pro Asp Leu Arg Arg 
65                  70                  75                  80  


Asp Val Tyr Leu Gln Asp Ile His Cys Val Ser Ser Leu Cys Lys Ala 
                85                  90                  95      


Tyr Phe Arg Glu Leu Pro Asp Pro Leu Leu Xaa Tyr Arg Leu Tyr Asp 
            100                 105                 110         


Lys Phe Ala Glu Ala Val Gly Val Gln Leu Glu Pro Glu Arg Leu Val 
        115                 120                 125             


Lys Ile Leu Glu Val Leu Arg Glu Leu Pro Val Pro Asn Tyr Arg Xaa 
    130                 135                 140                 


Leu Glu Phe Leu Met Arg His Leu Val His Met Ala Ser Phe Ser Ala 
145                 150                 155                 160 


Gln Xaa Asn Met His Ala Arg Asn Leu Ala Ile Val Trp Ala Pro Asn 
                165                 170                 175     


Leu Leu Arg Ser Lys Asp Ile Glu Ala Ser Gly Phe Asn Gly Xaa Ala 
            180                 185                 190         


Ala Phe Met Glu Val Arg Val Gln Ser Ile Val Val Glu Phe Ile Leu 
        195                 200                 205             


Xaa His Val Asp Gln Leu Phe Gly Gly Ala Ala Leu Ser Gly Gly Glu 
    210                 215                 220                 


Val Glu Ser Gly Trp Arg Ser Leu Pro Gly Xaa Arg Ala Ser Gly Ser 
225                 230                 235                 240 


Pro Glu Asp Leu Met Pro Arg Pro Leu Pro Tyr His Leu Pro Ser Ile 
                245                 250                 255     


Leu Gln Ala Gly Asp Gly Pro Pro Gln Met Arg Pro Tyr His Xaa Ile 
            260                 265                 270         


Ile Glu Ile Ala Glu His Lys Arg Lys Gly Ser Leu Lys Val Arg Lys 
        275                 280                 285             


Trp Arg Ser Ile Phe Asn Leu Gly Arg Ser Gly His Glu Xaa Lys Arg 
    290                 295                 300                 


Lys Leu Pro Arg Gly Ala Glu Asp Arg Glu Asp Lys Ser Asn Lys Gly 
305                 310                 315                 320 


Xaa Leu Arg Pro Ala Lys Ser Met Asp Ser Leu Ser Ala Ala Ala Gly 
                325                 330                 335     


Ala Ser Asp Glu Pro Glu Gly Leu Val Gly Pro Ser Ser Pro Arg Pro 
            340                 345                 350         


Ser Pro Leu Leu Pro Glu Ser Leu Glu Asn Asp Ser Ile Glu Ala Ala 
        355                 360                 365             


Glu Gly Glu Gln Glu Pro Glu Ala Glu Ala Leu Gly Gly Xaa Asn Ser 
    370                 375                 380                 


Glu Pro Gly Xaa Pro Arg Ala Gly Arg Ser Ala Ile Arg Ala Gly Gly 
385                 390                 395                 400 


Ser Ser Arg Ala Glu Arg Cys Ala Gly Val His Ile Ser Asp Pro Tyr 
                405                 410                 415     


Asn Val Asn Leu Pro Leu His Ile Xaa Ser Ile Leu Ser Val Pro Pro 
            420                 425                 430         


Asn Ile Ile Ser Asn Val Ser Leu Ala Arg Leu Xaa Arg Gly Leu Glu 
        435                 440                 445             


Cys Pro Ala Leu Gln His Arg Pro Ser Pro Ala Ser Gly Pro Gly Pro 
    450                 455                 460                 


Gly Pro Gly Leu Gly Pro Gly Pro Pro Asp Glu Lys Leu Glu Ala Ser 
465                 470                 475                 480 


Pro Ala Ser Ser Pro Leu Ala Asp Ser Gly Pro Asp Asp Leu Ala Pro 
                485                 490                 495     


Ala Leu Glu Asp Ser Leu Ser Gln Glu Val Gln Asp Ser Phe Ser Phe 
            500                 505                 510         


Leu Glu Asp Ser Ser Ser Ser Glu Pro Glu Trp Val Gly Ala Glu Asp 
        515                 520                 525             


Gly Glu Val Ala Gln Ala Glu Ala Ala Gly Ala Ala Phe Ser Pro Gly 
    530                 535                 540                 


Glu Asp Asp Pro Gly Met Gly Tyr Leu Glu Glu Leu Leu Gly Val Gly 
545                 550                 555                 560 


Pro Gln Val Glu Glu Phe Ser Val Glu Pro Pro Leu Asp Asp Leu Ser 
                565                 570                 575     


Leu Asp Glu Ala Gln Phe Val Leu Ala Pro Ser Cys Cys Ser Leu Asp 
            580                 585                 590         


Ser Ala Gly Pro Arg Pro Glu Val Glu Glu Glu Asn Gly Glu Glu Val 
        595                 600                 605             


Phe Leu Ser Ala Tyr Asp Asp Leu Ser Pro Leu Leu Gly Pro Lys Pro 
    610                 615                 620                 


Pro Ile Trp Lys Gly Ser Gly Ser Leu Glu Gly Glu Ala Ala Gly Cys 
625                 630                 635                 640 


Gly Arg Gln Ala Leu Gly Gln Gly Gly Glu Glu Gln Ala Cys Trp Glu 
                645                 650                 655     


Val Gly Glu Asp Lys Gln Ala Glu Pro Gly Gly Arg Leu Asp Ile Arg 
            660                 665                 670         


Glu Glu Ala Glu Gly Xaa Pro Gln Pro Pro Gln Pro Glu Glu Met Glu 
        675                 680                 685             


Pro Glu Gly Gln Pro Ser Pro Asp Gly Cys Leu Cys Pro Cys Ser Leu 
    690                 695                 700                 


Gly Leu Gly Gly Val Gly Met Arg Leu Ala Ser Xaa Leu Val Gln Val 
705                 710                 715                 720 


Gln Gln Val Arg Ser Val Pro Val Val Pro Pro Lys Pro Gln Phe Ala 
                725                 730                 735     


Lys Met Pro Ser Ala Met Cys Ser Lys Ile His Val Ala Pro Ala Asn 
            740                 745                 750         


Pro Cys Pro Arg Pro Gly Arg Leu Asp Gly Xaa Pro Gly Glu Arg Ala 
        755                 760                 765             


Trp Gly Ser Arg Ala Ser Arg Ser Ser Trp Arg Asn Gly Gly Ser Leu 
    770                 775                 780                 


Ser Phe Asp Ala Ala Val Ala Leu Ala Arg Asp Arg Gln Arg Xaa Glu 
785                 790                 795                 800 


Ala Gln Gly Val Arg Arg Xaa Gln Xaa Cys Xaa Glu Gly Gly Asp Tyr 
                805                 810                 815     


Cys Leu Ile Pro Arg Xaa Ser Pro Cys Ser Met Ile Ser Ala His Ser 
            820                 825                 830         


Pro Arg Pro Leu Ser Cys Leu Glu Leu Pro Ser Glu Gly Ala Glu Gly 
        835                 840                 845             


Ser Gly Ser Arg Ser Arg Leu Ser Leu Pro Pro Arg Glu Pro Gln Val 
    850                 855                 860                 


Pro Asp Pro Leu Leu Ser Ser Gln Arg Arg Ser Tyr Ala Phe Glu Xaa 
865                 870                 875                 880 


Gln Ala Asn Pro Gly Lys Gly Glu Gly Leu 
                885                 890 


<210> 2830
<211> 1101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1091)..(1091)
<223> Selenocysteine

<400> 2830
Met Lys Ser Arg Gln Lys Gly Lys Lys Lys Gly Ser Ala Lys Glu Arg 
1               5                   10                  15      


Val Phe Gly Cys Asp Leu Gln Glu His Leu Gln His Ser Gly Gln Glu 
            20                  25                  30          


Val Pro Gln Val Leu Lys Ser Cys Ala Glu Phe Val Glu Glu Tyr Gly 
        35                  40                  45              


Val Val Asp Gly Ile Tyr Arg Leu Ser Gly Val Ser Ser Asn Ile Gln 
    50                  55                  60                  


Lys Leu Arg Gln Glu Phe Glu Ser Glu Arg Lys Pro Asp Leu Arg Arg 
65                  70                  75                  80  


Asp Val Tyr Leu Gln Asp Ile His Cys Val Ser Ser Leu Cys Lys Ala 
                85                  90                  95      


Tyr Phe Arg Glu Leu Pro Asp Pro Leu Leu Xaa Tyr Arg Leu Tyr Asp 
            100                 105                 110         


Lys Phe Ala Glu Ala Val Gly Val Gln Leu Glu Pro Glu Arg Leu Val 
        115                 120                 125             


Lys Ile Leu Glu Val Leu Arg Glu Leu Pro Val Pro Asn Tyr Arg Xaa 
    130                 135                 140                 


Leu Glu Phe Leu Met Arg His Leu Val His Met Ala Ser Phe Ser Ala 
145                 150                 155                 160 


Gln Xaa Asn Met His Ala Arg Asn Leu Ala Ile Val Trp Ala Pro Asn 
                165                 170                 175     


Leu Leu Arg Ser Lys Asp Ile Glu Ala Ser Gly Phe Asn Gly Xaa Ala 
            180                 185                 190         


Ala Phe Met Glu Val Arg Val Gln Ser Ile Val Val Glu Phe Ile Leu 
        195                 200                 205             


Xaa His Val Asp Gln Leu Phe Gly Gly Ala Ala Leu Ser Gly Gly Glu 
    210                 215                 220                 


Val Glu Ser Gly Trp Arg Ser Leu Pro Gly Xaa Arg Ala Ser Gly Ser 
225                 230                 235                 240 


Pro Glu Asp Leu Met Pro Arg Pro Leu Pro Tyr His Leu Pro Ser Ile 
                245                 250                 255     


Leu Gln Ala Gly Asp Gly Pro Pro Gln Met Arg Pro Tyr His Xaa Ile 
            260                 265                 270         


Ile Glu Ile Ala Glu His Lys Arg Lys Gly Ser Leu Lys Val Arg Lys 
        275                 280                 285             


Trp Arg Ser Ile Phe Asn Leu Gly Arg Ser Gly His Glu Xaa Lys Arg 
    290                 295                 300                 


Lys Leu Pro Arg Gly Ala Glu Asp Arg Glu Asp Lys Ser Asn Lys Gly 
305                 310                 315                 320 


Xaa Leu Arg Pro Ala Lys Ser Met Asp Ser Leu Ser Ala Ala Ala Gly 
                325                 330                 335     


Ala Ser Asp Glu Pro Glu Gly Leu Val Gly Pro Ser Ser Pro Arg Pro 
            340                 345                 350         


Ser Pro Leu Leu Pro Glu Ser Leu Glu Asn Asp Ser Ile Glu Ala Ala 
        355                 360                 365             


Glu Gly Glu Gln Glu Pro Glu Ala Glu Ala Leu Gly Gly Xaa Asn Ser 
    370                 375                 380                 


Glu Pro Gly Xaa Pro Arg Ala Gly Arg Ser Ala Ile Arg Ala Gly Gly 
385                 390                 395                 400 


Ser Ser Arg Ala Glu Arg Cys Ala Gly Val His Ile Ser Asp Pro Tyr 
                405                 410                 415     


Asn Val Asn Leu Pro Leu His Ile Xaa Ser Ile Leu Ser Val Pro Pro 
            420                 425                 430         


Asn Ile Ile Ser Asn Val Ser Leu Ala Arg Leu Xaa Arg Gly Leu Glu 
        435                 440                 445             


Cys Pro Ala Leu Gln His Arg Pro Ser Pro Ala Ser Gly Pro Gly Pro 
    450                 455                 460                 


Gly Pro Gly Leu Gly Pro Gly Pro Pro Asp Glu Lys Leu Glu Ala Ser 
465                 470                 475                 480 


Pro Ala Ser Ser Pro Leu Ala Asp Ser Gly Pro Asp Asp Leu Ala Pro 
                485                 490                 495     


Ala Leu Glu Asp Ser Leu Ser Gln Glu Val Gln Asp Ser Phe Ser Phe 
            500                 505                 510         


Leu Glu Asp Ser Ser Ser Ser Glu Pro Glu Trp Val Gly Ala Glu Asp 
        515                 520                 525             


Gly Glu Val Ala Gln Ala Glu Ala Ala Gly Ala Ala Phe Ser Pro Gly 
    530                 535                 540                 


Glu Asp Asp Pro Gly Met Gly Tyr Leu Glu Glu Leu Leu Gly Val Gly 
545                 550                 555                 560 


Pro Gln Val Glu Glu Phe Ser Val Glu Pro Pro Leu Asp Asp Leu Ser 
                565                 570                 575     


Leu Asp Glu Ala Gln Phe Val Leu Ala Pro Ser Cys Cys Ser Leu Asp 
            580                 585                 590         


Ser Ala Gly Pro Arg Pro Glu Val Glu Glu Glu Asn Gly Glu Glu Val 
        595                 600                 605             


Phe Leu Ser Ala Tyr Asp Asp Leu Ser Pro Leu Leu Gly Pro Lys Pro 
    610                 615                 620                 


Pro Ile Trp Lys Gly Ser Gly Ser Leu Glu Gly Glu Ala Ala Gly Cys 
625                 630                 635                 640 


Gly Arg Gln Ala Leu Gly Gln Gly Gly Glu Glu Gln Ala Cys Trp Glu 
                645                 650                 655     


Val Gly Glu Asp Lys Gln Ala Glu Pro Gly Gly Arg Leu Asp Ile Arg 
            660                 665                 670         


Glu Glu Ala Glu Gly Ser Pro Glu Xaa Lys Val Glu Ala Gly Lys Ala 
        675                 680                 685             


Ser Glu Asp Arg Gly Glu Ala Gly Gly Ser Gln Glu Xaa Lys Val Arg 
    690                 695                 700                 


Leu Arg Glu Gly Ser Arg Glu Glu Xaa Glu Ala Lys Glu Glu Lys Ser 
705                 710                 715                 720 


Lys Gly Gln Lys Lys Ala Asp Ser Met Glu Ala Lys Gly Val Glu Glu 
                725                 730                 735     


Pro Gly Gly Asp Glu Tyr Xaa Asp Glu Lys Glu Lys Glu Ile Glu Arg 
            740                 745                 750         


Glu Glu Asp Glu Gln Arg Glu Glu Ala Gln Val Glu Ala Gly Arg Asp 
        755                 760                 765             


Leu Glu Gln Gly Ala Gln Glu Asp Gln Val Ala Glu Glu Lys Trp Glu 
    770                 775                 780                 


Val Val Gln Lys Gln Glu Ala Glu Gly Val Arg Glu Asp Glu Asp Lys 
785                 790                 795                 800 


Gly Gln Arg Glu Lys Gly Tyr His Glu Ala Arg Lys Asp Gln Gly Asp 
                805                 810                 815     


Gly Glu Asp Ser Arg Ser Pro Glu Ala Ala Xaa Glu Gly Gly Ala Gly 
            820                 825                 830         


Glu Val Ser Lys Glu Arg Glu Ser Gly Asp Gly Glu Ala Glu Gly Asp 
        835                 840                 845             


Gln Arg Ala Gly Gly Tyr Tyr Leu Glu Glu Asp Xaa Leu Ser Glu Gly 
    850                 855                 860                 


Ser Gly Val Ala Ser Leu Glu Val Asp Cys Ala Lys Glu Gly Asn Pro 
865                 870                 875                 880 


His Ser Ser Glu Met Glu Glu Val Ala Pro Gln Pro Pro Gln Pro Glu 
                885                 890                 895     


Glu Met Glu Pro Glu Gly Gln Pro Ser Pro Asp Gly Cys Leu Cys Pro 
            900                 905                 910         


Cys Ser Leu Gly Leu Gly Gly Val Gly Met Arg Leu Ala Ser Xaa Leu 
        915                 920                 925             


Val Gln Val Gln Gln Val Arg Ser Val Pro Val Val Pro Pro Lys Pro 
    930                 935                 940                 


Gln Phe Ala Lys Met Pro Ser Ala Met Cys Ser Lys Ile His Val Ala 
945                 950                 955                 960 


Pro Ala Asn Pro Cys Pro Arg Pro Gly Arg Leu Asp Gly Xaa Pro Gly 
                965                 970                 975     


Glu Arg Ala Trp Gly Ser Arg Ala Ser Arg Ser Ser Trp Arg Asn Gly 
            980                 985                 990         


Gly Ser Leu Ser Phe Asp Ala Ala  Val Ala Leu Ala Arg  Asp Arg Gln 
        995                 1000                 1005             


Arg Xaa  Glu Ala Gln Gly Val  Arg Arg Xaa Gln Xaa  Cys Xaa Glu 
    1010                 1015                 1020             


Gly Gly  Asp Tyr Cys Leu Ile  Pro Arg Xaa Ser Pro  Cys Ser Met 
    1025                 1030                 1035             


Ile Ser  Ala His Ser Pro Arg  Pro Leu Ser Cys Leu  Glu Leu Pro 
    1040                 1045                 1050             


Ser Glu  Gly Ala Glu Gly Ser  Gly Ser Arg Ser Arg  Leu Ser Leu 
    1055                 1060                 1065             


Pro Pro  Arg Glu Pro Gln Val  Pro Asp Pro Leu Leu  Ser Ser Gln 
    1070                 1075                 1080             


Arg Arg  Ser Tyr Ala Phe Glu  Xaa Gln Ala Asn Pro  Gly Lys Gly 
    1085                 1090                 1095             


Glu Gly  Leu 
    1100     


<210> 2831
<211> 69
<212> PRT
<213> Homo sapiens

<400> 2831
Met Lys Ser Arg Gln Lys Gly Lys Lys Lys Gly Ser Ala Lys Glu Arg 
1               5                   10                  15      


Val Phe Gly Cys Asp Leu Gln Glu His Leu Gln His Ser Gly Gln Glu 
            20                  25                  30          


Val Pro Gln Val Leu Lys Ser Cys Ala Glu Phe Val Glu Glu Tyr Gly 
        35                  40                  45              


Val Val Asp Gly Ile Tyr Arg Leu Ser Gly Val Ser Ser Asn Ile Gln 
    50                  55                  60                  


Lys Leu Arg Arg Leu 
65                  


<210> 2832
<211> 165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<400> 2832
Met Cys His Leu Val Pro Tyr Val Leu Lys Ser Cys Ala Glu Phe Ile 
1               5                   10                  15      


Glu Xaa His Gly Ile Val Asp Gly Ile Tyr Arg Leu Ser Gly Val Xaa 
            20                  25                  30          


Ser Asn Ile Gln Arg Leu Arg Gln Glu Phe Gly Ser Asp Gln Cys Pro 
        35                  40                  45              


Asp Leu Xaa Arg Glu Val Tyr Leu Gln Asp Ile His Cys Val Gly Ser 
    50                  55                  60                  


Leu Cys Lys Leu Tyr Phe Arg Glu Leu Pro Asn Pro Leu Leu Xaa Tyr 
65                  70                  75                  80  


Glu Leu Tyr Glu Lys Phe Xaa Glu Ala Val Ser His Cys Pro Glu Glu 
                85                  90                  95      


Gly Gln Leu Ala Arg Ile Gln Asn Val Ile Gln Glu Leu Pro Pro Ser 
            100                 105                 110         


His Tyr Arg Xaa Leu Glu Tyr Leu Ile Arg His Leu Ala His Ile Ala 
        115                 120                 125             


Ser Phe Ser Ser Lys Xaa Asn Met His Ala Arg Asn Leu Ala Leu Val 
    130                 135                 140                 


Trp Ala Pro Asn Leu Leu Arg Ser Lys Glu Ile Glu Ala Xaa Gly Cys 
145                 150                 155                 160 


Asn Gly Asp Ala Ala 
                165 


<210> 2833
<211> 1444
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1093)..(1093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1173)..(1173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1278)..(1278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1287)..(1287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1300)..(1300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1314)..(1314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1365)..(1365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1367)..(1367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1380)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1382)..(1382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1396)..(1396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1399)..(1399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1410)..(1410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1422)..(1422)
<223> Selenocysteine

<400> 2833
Met Lys Asn Lys Gly Ala Lys Gln Lys Leu Lys Arg Lys Gly Ala Ala 
1               5                   10                  15      


Ser Ala Phe Gly Cys Asp Leu Xaa Glu Tyr Leu Glu Ser Ser Gly Gln 
            20                  25                  30          


Asp Val Pro Tyr Val Leu Lys Ser Cys Ala Glu Phe Ile Glu Xaa His 
        35                  40                  45              


Gly Ile Val Asp Gly Ile Tyr Arg Leu Ser Gly Val Xaa Ser Asn Ile 
    50                  55                  60                  


Gln Arg Leu Arg Gln Glu Phe Gly Ser Asp Gln Cys Pro Asp Leu Xaa 
65                  70                  75                  80  


Arg Glu Val Tyr Leu Gln Asp Ile His Cys Val Gly Ser Leu Cys Lys 
                85                  90                  95      


Leu Tyr Phe Arg Glu Leu Pro Asn Pro Leu Leu Xaa Tyr Glu Leu Tyr 
            100                 105                 110         


Glu Lys Phe Xaa Glu Ala Val Ser His Cys Pro Glu Glu Gly Gln Leu 
        115                 120                 125             


Ala Arg Ile Gln Asn Val Ile Gln Glu Leu Pro Pro Ser His Tyr Arg 
    130                 135                 140                 


Xaa Leu Glu Tyr Leu Ile Arg His Leu Ala His Ile Ala Ser Phe Ser 
145                 150                 155                 160 


Ser Lys Xaa Asn Met His Ala Arg Asn Leu Ala Leu Val Trp Ala Pro 
                165                 170                 175     


Asn Leu Leu Arg Ser Lys Glu Ile Glu Ala Xaa Gly Cys Asn Gly Asp 
            180                 185                 190         


Ala Ala Phe Leu Ala Val Arg Val Gln Gln Val Val Ile Glu Phe Ile 
        195                 200                 205             


Leu Asn His Val Asp Gln Ile Phe Asn Asn Gly Ala Pro Gly Ser Leu 
    210                 215                 220                 


Glu Asn Asp Glu Asn Arg Pro Ile Met Lys Ser Leu Xaa Leu Pro Ala 
225                 230                 235                 240 


Leu Ser Leu Pro Met Lys Leu Val Ser Leu Glu Glu Ala Gln Ala Arg 
                245                 250                 255     


Ser Leu Ala Xaa Asn His Pro Ala Arg Lys Glu Arg Arg Glu Asn Ser 
            260                 265                 270         


Leu Pro Glu Ile Val Pro Pro Met Gly Xaa Leu Phe His Xaa Val Leu 
        275                 280                 285             


Glu Leu Pro Asp Asn Lys Arg Lys Leu Ser Ser Lys Ser Lys Lys Trp 
    290                 295                 300                 


Lys Ser Ile Phe Asn Leu Gly Arg Ser Gly Ser Asp Ser Lys Ser Lys 
305                 310                 315                 320 


Leu Ser Arg Asn Gly Ser Val Phe Val Arg Gly Gln Arg Leu Ser Val 
                325                 330                 335     


Glu Lys Ala Xaa Ile Arg Pro Ala Lys Ser Met Asp Ser Leu Cys Ser 
            340                 345                 350         


Val Pro Val Glu Gly Lys Glu Xaa Lys Gly Asn Phe Asn Arg Xaa Val 
        355                 360                 365             


Xaa Xaa Gly Gly Phe Phe Ile Pro Ala Xaa Lys Met His Ser Xaa Gly 
    370                 375                 380                 


Xaa Gly Ser Ser Cys Asp Leu Xaa Lys Gln Glu Gly Glu Trp Gly Gln 
385                 390                 395                 400 


Glu Gly Met Pro Pro Gly Ala Glu Gly Gly Phe Asp Val Ser Ser Asp 
                405                 410                 415     


Arg Ser His Leu Gln Gly Ala Gln Ala Arg Pro Pro Pro Glu Gln Leu 
            420                 425                 430         


Lys Val Phe Arg Pro Val Glu Asp Pro Glu Ser Glu Gln Xaa Ala Pro 
        435                 440                 445             


Lys Met Leu Gly Met Phe Tyr Xaa Ser Asn Asp Ser Pro Ser Lys Ser 
    450                 455                 460                 


Val Phe Xaa Ser Ser Leu Phe Gln Met Glu Pro Ser Pro Arg Asn Gln 
465                 470                 475                 480 


Arg Lys Ala Leu Asn Ile Ser Glu Pro Phe Ala Val Ser Val Pro Leu 
                485                 490                 495     


Arg Val Ser Ala Val Ile Ser Xaa Asn Ser Xaa Pro Cys Arg Xaa Pro 
            500                 505                 510         


Pro Lys Glu Leu Gln Ser Leu Ser Ser Leu Glu Glu Phe Ser Phe His 
        515                 520                 525             


Gly Ser Glu Ser Gly Gly Trp Pro Glu Glu Glu Lys Pro Leu Gly Ala 
    530                 535                 540                 


Glu Xaa Ser Ala Ala Ser Val Pro Lys Lys Ala Gly Leu Glu Asp Ala 
545                 550                 555                 560 


Lys Ala Val Pro Glu Ala Pro Gly Xaa Val Glu Cys Ser Lys Gly Leu 
                565                 570                 575     


Ser Gln Glu Pro Gly Ala His Leu Glu Glu Lys Lys Xaa Pro Glu Ser 
            580                 585                 590         


Ser Leu Ser Ser Gln His Leu Asn Glu Leu Glu Lys Arg Pro Asn Pro 
        595                 600                 605             


Glu Lys Val Val Glu Glu Gly Arg Glu Ala Gly Glu Met Glu Ser Ser 
    610                 615                 620                 


Xaa Leu Gln Glu Ser Pro Arg Ala Arg Ala Glu Ala Val Leu Leu His 
625                 630                 635                 640 


Glu Met Asp Glu Asp Asp Leu Ala Asn Ala Leu Ile Trp Pro Glu Ile 
                645                 650                 655     


Gln Gln Glu Leu Lys Ile Ile Glu Ser Glu Glu Glu Leu Ser Ser Leu 
            660                 665                 670         


Pro Pro Pro Ala Leu Lys Xaa Ser Pro Ile Gln Pro Ile Leu Glu Ser 
        675                 680                 685             


Ser Leu Gly Pro Phe Ile Pro Ser Glu Pro Pro Gly Ser Leu Pro Cys 
    690                 695                 700                 


Gly Ser Phe Pro Ala Pro Val Ser Xaa Pro Leu Glu Val Trp Xaa Arg 
705                 710                 715                 720 


Asp Pro Ala Asn Gln Ser Xaa Gln Gly Ala Ser Xaa Ala Ala Ser Arg 
                725                 730                 735     


Glu Lys Pro Glu Pro Glu Gln Gly Leu His Pro Asp Leu Ala Ser Leu 
            740                 745                 750         


Ala Pro Leu Glu Ile Val Pro Phe Glu Lys Ala Ser Pro Gln Ala Xaa 
        755                 760                 765             


Val Glu Val Gly Gly Pro Gly Asn Leu Ser Pro Pro Leu Pro Pro Ala 
    770                 775                 780                 


Pro Pro Pro Pro Xaa Pro Leu Glu Glu Ser Xaa Pro Val Leu Leu Ser 
785                 790                 795                 800 


Lys Gly Gly Pro Glu Arg Glu Asp Ser Ser Arg Lys Leu Arg Xaa Asp 
                805                 810                 815     


Leu Tyr Ile Asp Gln Leu Lys Ser Gln Asp Ser Pro Glu Ile Ser Ser 
            820                 825                 830         


Leu Cys Gln Gly Glu Glu Ala Xaa Pro Arg His Ser Asp Lys Gln Asn 
        835                 840                 845             


Ser Lys Asn Ala Ala Ser Glu Gly Lys Gly Cys Gly Phe Pro Ser Pro 
    850                 855                 860                 


Xaa Arg Glu Val Glu Ile Val Ser Gln Glu Glu Glu Asp Val Xaa His 
865                 870                 875                 880 


Ser Val Gln Glu Pro Ser Asp Cys Asp Glu Asp Asp Xaa Val Xaa Asp 
                885                 890                 895     


Ile Ala Gln His Gly Leu Glu Met Val Glu Pro Trp Glu Glu Pro Gln 
            900                 905                 910         


Trp Val Xaa Ser Pro Leu His Ser Pro Xaa Leu Lys Asp Ala His Lys 
        915                 920                 925             


Ala Gln Val Gln Gly Leu Gln Gly His Gln Leu Glu Lys Arg Leu Ser 
    930                 935                 940                 


His Arg Pro Ser Leu Arg Gln Ser His Ser Leu Asp Ser Lys Pro Xaa 
945                 950                 955                 960 


Val Lys Ser Gln Trp Xaa Leu Glu Val Pro Ser Ser Ser Ser Cys Ala 
                965                 970                 975     


Asn Leu Glu Xaa Glu Arg Asn Ser Asp Pro Leu Gln Pro Gln Ala Pro 
            980                 985                 990         


Arg Arg Glu Ile Xaa Gly Trp Asp  Glu Lys Ala Leu Arg  Ser Phe Arg 
        995                 1000                 1005             


Glu Phe  Ser Gly Leu Lys Gly  Ala Glu Ala Pro Pro  Asn Gln Lys 
    1010                 1015                 1020             


Gly Pro  Ser Gly Val Gln Pro  Asn Pro Ala Glu Xaa  Ser Pro Ile 
    1025                 1030                 1035             


Ser Leu  Ala Glu Gly Lys Glu  Leu Gly Xaa His Leu  Gly His Ser 
    1040                 1045                 1050             


Ser Pro  Gln Ile Arg Gln Gly  Gly Val Pro Gly Pro  Glu Ser Ser 
    1055                 1060                 1065             


Lys Glu  Ser Ser Pro Ser Val  Gln Asp Ser Xaa Ser  Pro Gly Glu 
    1070                 1075                 1080             


His Pro  Ala Lys Leu Gln Leu  Lys Ser Xaa Glu Cys  Gly Pro Pro 
    1085                 1090                 1095             


Lys Gly  Lys Asn Arg Pro Ser  Ser Leu Asn Leu Asp  Pro Ala Ile 
    1100                 1105                 1110             


Pro Ile  Ala Asp Leu Phe Trp  Phe Glu Asn Val Ala  Ser Phe Ser 
    1115                 1120                 1125             


Ser Pro  Gly Met Gln Val Ser  Glu Pro Gly Asp Pro  Lys Val Xaa 
    1130                 1135                 1140             


Trp Met  Xaa Ser Ser Tyr Cys  Lys Ala Asp Pro Trp  Arg Val Tyr 
    1145                 1150                 1155             


Ser Gln  Asp Pro Gln Asp Leu  Asp Ile Val Ala His  Ala Leu Xaa 
    1160                 1165                 1170             


Gly Arg  Arg Asn Ser Ala Pro  Val Ser Val Ser Ala  Val Arg Xaa 
    1175                 1180                 1185             


Ser Phe  Met Val Lys Met Cys  Gln Ala Arg Ala Val  Pro Val Ile 
    1190                 1195                 1200             


Pro Pro  Lys Ile Gln Tyr Xaa  Gln Ile Pro Gln Pro  Leu Pro Ser 
    1205                 1210                 1215             


Gln Ser  Ser Gly Glu Asn Gly  Val Gln Pro Leu Glu  Arg Ser Gln 
    1220                 1225                 1230             


Glu Gly  Pro Ser Ser Xaa Ser  Gly Xaa Xaa Gln Lys  Pro Ala Lys 
    1235                 1240                 1245             


Asp Asp  Ser Pro Ser Ser Leu  Glu Ser Ser Lys Glu  Glu Lys Pro 
    1250                 1255                 1260             


Lys Gln  Asp Pro Gly Ala Ile  Lys Ser Ser Pro Val  Asp Ala Xaa 
    1265                 1270                 1275             


Ala Pro  Cys Met Cys Glu Gly  Pro Xaa Leu Ser Pro  Glu Pro Gly 
    1280                 1285                 1290             


Ser Ser  Asn Leu Leu Ser Xaa  Gln Asp Ala Val Val  Gln Cys Arg 
    1295                 1300                 1305             


Lys Arg  Met Ser Glu Xaa Glu  Pro Ser Gly Asp Asn  Leu Leu Ser 
    1310                 1315                 1320             


Ser Lys  Leu Glu Arg Pro Ser  Gly Gly Ser Lys Pro  Phe His Arg 
    1325                 1330                 1335             


Ser Arg  Pro Gly Arg Pro Gln  Ser Leu Ile Leu Phe  Ser Pro Pro 
    1340                 1345                 1350             


Phe Pro  Ile Met Asp His Leu  Pro Pro Ser Ser Xaa  Val Xaa Asp 
    1355                 1360                 1365             


Ser Lys  Val Leu Leu Ser Pro  Ile Arg Ser Pro Xaa  Gln Xaa Val 
    1370                 1375                 1380             


Ser Pro  Gly Leu Leu Cys Gly  Glu Leu Ala Glu Asn  Xaa Trp Val 
    1385                 1390                 1395             


Xaa Pro  Glu Gly Val Xaa Leu  Arg Asn Lys Met Xaa  Ile Pro Lys 
    1400                 1405                 1410             


Asn Gly  Gln Arg Leu Glu Xaa  Ser Xaa Ser Cys Phe  Tyr Gln Pro 
    1415                 1420                 1425             


Gln Arg  Arg Ser Val Ile Leu  Asp Gly Arg Ser Gly  Arg Gln Ile 
    1430                 1435                 1440             


Glu 
    


<210> 2834
<211> 946
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<400> 2834
Met Ala Arg Gly Ala Asp Val Pro Glu Ile Pro Gly Asp Leu Xaa Leu 
1               5                   10                  15      


Lys Xaa Cys Gly Ser Xaa Ala Ser Met Lys Val Lys His Val Lys Lys 
            20                  25                  30          


Leu Pro Phe Xaa Lys Gly His Phe Pro Lys Met Ala Glu Cys Ala His 
        35                  40                  45              


Phe His Tyr Glu Asn Val Glu Phe Gly Ser Ile Gln Leu Ser Leu Ser 
    50                  55                  60                  


Glu Glu Gln Asn Glu Val Met Lys Asn Gly Cys Glu Ser Lys Glu Leu 
65                  70                  75                  80  


Val Tyr Leu Val Gln Ile Ala Cys Gln Gly Lys Ser Trp Ile Val Lys 
                85                  90                  95      


Arg Ser Tyr Glu Asp Phe Arg Val Leu Asp Lys His Leu His Leu Cys 
            100                 105                 110         


Ile Tyr Asp Arg Arg Phe Ser Gln Leu Ser Glu Leu Pro Arg Ser Asp 
        115                 120                 125             


Xaa Leu Lys Asp Ser Pro Glu Ser Val Xaa Gln Met Leu Met Ala Tyr 
    130                 135                 140                 


Leu Ser Arg Leu Ser Ala Ile Ala Gly Asn Lys Ile Asn Cys Gly Pro 
145                 150                 155                 160 


Ala Leu Xaa Trp Met Glu Ile Asp Asn Lys Gly Asn His Leu Leu Val 
                165                 170                 175     


His Glu Glu Ser Ser Ile Asn Xaa Pro Ala Val Gly Ala Ala His Val 
            180                 185                 190         


Ile Lys Arg Tyr Xaa Ala Arg Ala Pro Asp Glu Leu Xaa Leu Glu Val 
        195                 200                 205             


Gly Asp Ile Val Ser Val Ile Asp Met Pro Pro Lys Val Leu Ser Xaa 
    210                 215                 220                 


Trp Trp Arg Gly Lys His Gly Phe Gln Val Gly Leu Phe Pro Gly His 
225                 230                 235                 240 


Cys Val Glu Leu Ile Asn Gln Lys Val Pro Gln Ser Val Xaa Asn Ser 
                245                 250                 255     


Val Pro Lys Pro Val Ser Lys Lys His Gly Lys Leu Ile Xaa Phe Leu 
            260                 265                 270         


Arg Xaa Phe Met Lys Ser Arg Pro Xaa Lys Gln Lys Leu Lys Gln Arg 
        275                 280                 285             


Gly Ile Leu Lys Glu Arg Val Phe Gly Cys Asp Leu Gly Glu His Leu 
    290                 295                 300                 


Leu Asn Ser Gly Phe Glu Val Pro Gln Val Leu Gln Ser Cys Xaa Ala 
305                 310                 315                 320 


Phe Ile Glu Arg Tyr Gly Ile Val Asp Gly Ile Tyr Arg Leu Ser Gly 
                325                 330                 335     


Val Ala Ser Asn Ile Gln Arg Leu Arg His Glu Phe Asp Ser Glu His 
            340                 345                 350         


Val Pro Asp Leu Xaa Lys Glu Pro Tyr Val Gln Asp Ile His Ser Val 
        355                 360                 365             


Gly Ser Leu Cys Lys Leu Tyr Phe Arg Glu Leu Pro Asn Pro Leu Leu 
    370                 375                 380                 


Xaa Tyr Gln Leu Tyr Glu Lys Phe Ser Asp Ala Val Ser Ala Ala Xaa 
385                 390                 395                 400 


Asp Glu Glu Arg Leu Ile Lys Ile His Asp Val Ile Gln Gln Leu Pro 
                405                 410                 415     


Pro Pro His Tyr Arg Xaa Leu Glu Phe Leu Met Arg His Leu Ser Leu 
            420                 425                 430         


Leu Ala Asp Tyr Cys Ser Ile Xaa Asn Met His Ala Lys Asn Leu Ala 
        435                 440                 445             


Ile Val Trp Ala Pro Asn Leu Leu Arg Ser Lys Gln Ile Glu Ser Ala 
    450                 455                 460                 


Cys Phe Ser Gly Xaa Ala Ala Phe Met Glu Val Arg Ile Gln Ser Val 
465                 470                 475                 480 


Val Val Glu Phe Ile Leu Asn His Val Asp Val Leu Phe Ser Gly Arg 
                485                 490                 495     


Ile Ser Met Ala Met Gln Glu Gly Ala Ala Ser Leu Ser Arg Pro Lys 
            500                 505                 510         


Ser Leu Leu Val Ser Ser Pro Ser Xaa Lys Leu Leu Xaa Leu Glu Glu 
        515                 520                 525             


Ala Gln Ala Arg Xaa Gln Ala Gln Val Asn Ser Pro Ile Val Xaa Glu 
    530                 535                 540                 


Asn Lys Tyr Ile Glu Val Gly Glu Gly Pro Ala Ala Leu Gln Gly Lys 
545                 550                 555                 560 


Phe His Xaa Ile Ile Glu Phe Pro Leu Glu Arg Lys Arg Pro Gln Asn 
                565                 570                 575     


Lys Met Lys Lys Ser Pro Val Gly Ser Trp Arg Ser Phe Phe Asn Leu 
            580                 585                 590         


Gly Lys Ser Ser Ser Val Ser Lys Arg Lys Leu Gln Arg Asn Glu Ser 
        595                 600                 605             


Glu Pro Ser Glu Met Lys Ala Met Ala Leu Lys Gly Gly Arg Ala Glu 
    610                 615                 620                 


Gly Xaa Leu Arg Ser Ala Lys Ser Glu Glu Ser Leu Xaa Ser Leu His 
625                 630                 635                 640 


Ala Val Asp Gly Asp Ser Lys Leu Phe Arg Pro Arg Arg Pro Arg Ser 
                645                 650                 655     


Ser Ser Asp Ala Leu Ser Ala Ser Phe Asn Gly Glu Met Leu Gly Asn 
            660                 665                 670         


Arg Cys Asn Ser Tyr Asp Asn Leu Pro His Asp Asn Glu Ser Glu Glu 
        675                 680                 685             


Glu Gly Gly Leu Leu His Ile Pro Ala Leu Met Ser Pro His Ser Ala 
    690                 695                 700                 


Glu Asp Val Asp Leu Ser Pro Pro Asp Ile Gly Val Ala Ser Leu Asp 
705                 710                 715                 720 


Phe Asp Pro Met Ser Phe Gln Cys Ser Pro Pro Lys Ala Glu Ser Glu 
                725                 730                 735     


Cys Leu Glu Ser Gly Ala Ser Phe Leu Asp Ser Pro Gly Tyr Ser Lys 
            740                 745                 750         


Asp Lys Pro Ser Ala Asn Lys Lys Asp Ala Glu Xaa Gly Ser Ser Gln 
        755                 760                 765             


Cys Gln Xaa Pro Gly Ser Xaa Ala Ser Ser Glu Pro Val Ser Pro Leu 
    770                 775                 780                 


Gln Glu Lys Leu Ser Pro Phe Phe Xaa Leu Asp Leu Ser Pro Xaa Glu 
785                 790                 795                 800 


Asp Lys Ser Ser Lys Pro Ser Ser Phe Xaa Glu Lys Val Val Tyr Ala 
                805                 810                 815     


Phe Ser Pro Lys Ile Gly Arg Lys Leu Ser Lys Ser Pro Ser Met Ser 
            820                 825                 830         


Ile Ser Glu Pro Ile Ser Val Xaa Leu Pro Pro Arg Val Ser Glu Val 
        835                 840                 845             


Ile Gly Xaa Val Ser Asn Xaa Xaa Ala Gln Asn Ala Ser Ser Ser Xaa 
    850                 855                 860                 


Trp Asp Lys Cys Val Glu Glu Arg Asp Ala Xaa Asn Arg Ser Pro Xaa 
865                 870                 875                 880 


Gln Ile Val Lys Met Lys Xaa Asn Glu Xaa Val Ala Gln Glu Ala Tyr 
                885                 890                 895     


Glu Ser Glu Val Gln Pro Leu Asp Gln Val Ala Ala Glu Glu Val Glu 
            900                 905                 910         


Leu Pro Gly Lys Glu Asp Gln Ser Val Ser Ser Ser Gln Ser Lys Ala 
        915                 920                 925             


Val Ala Ser Gly Gln Xaa Gln Xaa Gly Xaa Val Cys Phe Pro Pro Phe 
    930                 935                 940                 


Phe Leu 
945     


<210> 2835
<211> 2087
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (873)..(873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1131)..(1131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1260)..(1260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1262)..(1262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1270)..(1270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1287)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1299)..(1299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1328)..(1328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1416)..(1416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1435)..(1435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1449)..(1449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1471)..(1471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1482)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1497)..(1497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1536)..(1536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1579)..(1579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1602)..(1602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1635)..(1635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1675)..(1675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1716)..(1716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1738)..(1738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1777)..(1777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1801)..(1801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1848)..(1848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1914)..(1914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1974)..(1974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1994)..(1994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2018)..(2018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2047)..(2047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2060)..(2060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2063)..(2063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2082)..(2082)
<223> Selenocysteine

<400> 2835
Met Glu Xaa Glu Ser Glu Ser Ser Xaa Leu Gly Asp Asp Ser Val Phe 
1               5                   10                  15      


Trp Leu Glu Ser Glu Val Ile Ile Gln Val Xaa Asp Cys Glu Glu Glu 
            20                  25                  30          


Glu Arg Glu Glu Lys Phe Arg Lys Met Lys Ser Ser Val His Ser Glu 
        35                  40                  45              


Glu Asp Asp Phe Val Pro Glu Leu His Arg Asn Val His Pro Arg Glu 
    50                  55                  60                  


Arg Pro Asp Trp Glu Glu Xaa Leu Ser Ala Met Ala Arg Gly Ala Asp 
65                  70                  75                  80  


Val Pro Glu Ile Pro Gly Asp Leu Xaa Leu Lys Xaa Cys Gly Ser Xaa 
                85                  90                  95      


Ala Ser Met Lys Val Lys His Val Lys Lys Leu Pro Phe Xaa Lys Gly 
            100                 105                 110         


His Phe Pro Lys Met Ala Glu Cys Ala His Phe His Tyr Glu Asn Val 
        115                 120                 125             


Glu Phe Gly Ser Ile Gln Leu Ser Leu Ser Glu Glu Gln Asn Glu Val 
    130                 135                 140                 


Met Lys Asn Gly Cys Glu Ser Lys Glu Leu Val Tyr Leu Val Gln Ile 
145                 150                 155                 160 


Ala Cys Gln Gly Lys Ser Trp Ile Val Lys Arg Ser Tyr Glu Asp Phe 
                165                 170                 175     


Arg Val Leu Asp Lys His Leu His Leu Cys Ile Tyr Asp Arg Arg Phe 
            180                 185                 190         


Ser Gln Leu Ser Glu Leu Pro Arg Ser Asp Xaa Leu Lys Asp Ser Pro 
        195                 200                 205             


Glu Ser Val Xaa Gln Met Leu Met Ala Tyr Leu Ser Arg Leu Ser Ala 
    210                 215                 220                 


Ile Ala Gly Asn Lys Ile Asn Cys Gly Pro Ala Leu Xaa Trp Met Glu 
225                 230                 235                 240 


Ile Asp Asn Lys Gly Asn His Leu Leu Val His Glu Glu Ser Ser Ile 
                245                 250                 255     


Asn Xaa Pro Ala Val Gly Ala Ala His Val Ile Lys Arg Tyr Xaa Ala 
            260                 265                 270         


Arg Ala Pro Asp Glu Leu Xaa Leu Glu Val Gly Asp Ile Val Ser Val 
        275                 280                 285             


Ile Asp Met Pro Pro Lys Val Leu Ser Xaa Trp Trp Arg Gly Lys His 
    290                 295                 300                 


Gly Phe Gln Val Gly Leu Phe Pro Gly His Cys Val Glu Leu Ile Asn 
305                 310                 315                 320 


Gln Lys Val Pro Gln Ser Val Xaa Asn Ser Val Pro Lys Pro Val Ser 
                325                 330                 335     


Lys Lys His Gly Lys Leu Ile Xaa Phe Leu Arg Xaa Phe Met Lys Ser 
            340                 345                 350         


Arg Pro Xaa Lys Gln Lys Leu Lys Gln Arg Gly Ile Leu Lys Glu Arg 
        355                 360                 365             


Val Phe Gly Cys Asp Leu Gly Glu His Leu Leu Asn Ser Gly Phe Glu 
    370                 375                 380                 


Val Pro Gln Val Leu Gln Ser Cys Xaa Ala Phe Ile Glu Arg Tyr Gly 
385                 390                 395                 400 


Ile Val Asp Gly Ile Tyr Arg Leu Ser Gly Val Ala Ser Asn Ile Gln 
                405                 410                 415     


Arg Leu Arg His Glu Phe Asp Ser Glu His Val Pro Asp Leu Xaa Lys 
            420                 425                 430         


Glu Pro Tyr Val Gln Asp Ile His Ser Val Gly Ser Leu Cys Lys Leu 
        435                 440                 445             


Tyr Phe Arg Glu Leu Pro Asn Pro Leu Leu Xaa Tyr Gln Leu Tyr Glu 
    450                 455                 460                 


Lys Phe Ser Asp Ala Val Ser Ala Ala Xaa Asp Glu Glu Arg Leu Ile 
465                 470                 475                 480 


Lys Ile His Asp Val Ile Gln Gln Leu Pro Pro Pro His Tyr Arg Xaa 
                485                 490                 495     


Leu Glu Phe Leu Met Arg His Leu Ser Leu Leu Ala Asp Tyr Cys Ser 
            500                 505                 510         


Ile Xaa Asn Met His Ala Lys Asn Leu Ala Ile Val Trp Ala Pro Asn 
        515                 520                 525             


Leu Leu Arg Ser Lys Gln Ile Glu Ser Ala Cys Phe Ser Gly Xaa Ala 
    530                 535                 540                 


Ala Phe Met Glu Val Arg Ile Gln Ser Val Val Val Glu Phe Ile Leu 
545                 550                 555                 560 


Asn His Val Asp Val Leu Phe Ser Gly Arg Ile Ser Met Ala Met Gln 
                565                 570                 575     


Glu Gly Ala Ala Ser Leu Ser Arg Pro Lys Ser Leu Leu Val Ser Ser 
            580                 585                 590         


Pro Ser Xaa Lys Leu Leu Xaa Leu Glu Glu Ala Gln Ala Arg Xaa Gln 
        595                 600                 605             


Ala Gln Val Asn Ser Pro Ile Val Xaa Glu Asn Lys Tyr Ile Glu Val 
    610                 615                 620                 


Gly Glu Gly Pro Ala Ala Leu Gln Gly Lys Phe His Xaa Ile Ile Glu 
625                 630                 635                 640 


Phe Pro Leu Glu Arg Lys Arg Pro Gln Asn Lys Met Lys Lys Ser Pro 
                645                 650                 655     


Val Gly Ser Trp Arg Ser Phe Phe Asn Leu Gly Lys Ser Ser Ser Val 
            660                 665                 670         


Ser Lys Arg Lys Leu Gln Arg Asn Glu Ser Glu Pro Ser Glu Met Lys 
        675                 680                 685             


Ala Met Ala Leu Lys Gly Gly Arg Ala Glu Gly Xaa Leu Arg Ser Ala 
    690                 695                 700                 


Lys Ser Glu Glu Ser Leu Xaa Ser Leu His Ala Val Asp Gly Asp Ser 
705                 710                 715                 720 


Lys Leu Phe Arg Pro Arg Arg Pro Arg Ser Ser Ser Asp Ala Leu Ser 
                725                 730                 735     


Ala Ser Phe Asn Gly Glu Met Leu Gly Asn Arg Cys Asn Ser Tyr Asp 
            740                 745                 750         


Asn Leu Pro His Asp Asn Glu Ser Glu Glu Glu Gly Gly Leu Leu His 
        755                 760                 765             


Ile Pro Ala Leu Met Ser Pro His Ser Ala Glu Asp Val Asp Leu Ser 
    770                 775                 780                 


Pro Pro Asp Ile Gly Val Ala Ser Leu Asp Phe Asp Pro Met Ser Phe 
785                 790                 795                 800 


Gln Cys Ser Pro Pro Lys Ala Glu Ser Glu Cys Leu Glu Ser Gly Ala 
                805                 810                 815     


Ser Phe Leu Asp Ser Pro Gly Tyr Ser Lys Asp Lys Pro Ser Ala Asn 
            820                 825                 830         


Lys Lys Asp Ala Glu Xaa Gly Ser Ser Gln Cys Gln Xaa Pro Gly Ser 
        835                 840                 845             


Xaa Ala Ser Ser Glu Pro Val Ser Pro Leu Gln Glu Lys Leu Ser Pro 
    850                 855                 860                 


Phe Phe Xaa Leu Asp Leu Ser Pro Xaa Glu Asp Lys Ser Ser Lys Pro 
865                 870                 875                 880 


Ser Ser Phe Xaa Glu Lys Val Val Tyr Ala Phe Ser Pro Lys Ile Gly 
                885                 890                 895     


Arg Lys Leu Ser Lys Ser Pro Ser Met Ser Ile Ser Glu Pro Ile Ser 
            900                 905                 910         


Val Xaa Leu Pro Pro Arg Val Ser Glu Val Ile Gly Xaa Val Ser Asn 
        915                 920                 925             


Xaa Xaa Ala Gln Asn Ala Ser Ser Ser Xaa Trp Asp Lys Cys Val Glu 
    930                 935                 940                 


Glu Arg Asp Ala Xaa Asn Arg Ser Pro Xaa Gln Ile Val Lys Met Lys 
945                 950                 955                 960 


Xaa Asn Glu Xaa Val Ala Gln Glu Ala Tyr Glu Ser Glu Val Gln Pro 
                965                 970                 975     


Leu Asp Gln Val Ala Ala Glu Glu Val Glu Leu Pro Gly Lys Glu Asp 
            980                 985                 990         


Gln Ser Val Ser Ser Ser Gln Ser  Lys Ala Val Ala Ser  Gly Gln Xaa 
        995                 1000                 1005             


Gln Xaa  Gly Ala Val Xaa His  Asp Pro Pro Gln Asp  Ser Val Pro 
    1010                 1015                 1020             


Val Ser  Ser Val Ser Leu Ile  Pro Pro Pro Pro Pro  Pro Lys Asn 
    1025                 1030                 1035             


Val Ala  Arg Met Leu Ala Leu  Ala Leu Ala Glu Ser  Ala Gln Gln 
    1040                 1045                 1050             


Ala Ser  Xaa Gln Ser Leu Lys  Arg Pro Gly Xaa Ser  Gln Ala Gly 
    1055                 1060                 1065             


Tyr Xaa  Asn Tyr Gly Asp Ile  Ala Val Ala Xaa Xaa  Glu Asp Asn 
    1070                 1075                 1080             


Leu Ser  Ser Ser Tyr Ser Ala  Val Ala Leu Asp Lys  Ala Tyr Phe 
    1085                 1090                 1095             


Gln Xaa  Asp Arg Pro Ala Glu  Gln Phe His Leu Gln  Asn Asn Ala 
    1100                 1105                 1110             


Pro Gly  Asn Cys Asp His Pro  Leu Pro Glu Xaa Xaa  Ala Xaa Gly 
    1115                 1120                 1125             


Asp Pro  Xaa His Ser Asn Xaa  Xaa Glu Ser Gly Glu  Gln His His 
    1130                 1135                 1140             


Gln Val  Asp Leu Xaa Gly Asn  Gln Pro His Gln Ala  Tyr Leu Ser 
    1145                 1150                 1155             


Gly Asp  Pro Glu Lys Ala Arg  Ile Xaa Ser Val Pro  Leu Asp Ser 
    1160                 1165                 1170             


Glu Lys  Ser Asp Asp His Val  Ser Phe Pro Glu Asp  Gln Ser Gly 
    1175                 1180                 1185             


Lys Asn  Ser Met Pro Xaa Val  Ser Phe Leu Asp Gln  Asp Gln Ser 
    1190                 1195                 1200             


Pro Pro  Arg Phe Tyr Ser Gly  Asp Gln Pro Pro Ser  Tyr Leu Gly 
    1205                 1210                 1215             


Ala Ser  Val Asp Lys Leu His  His Pro Leu Glu Phe  Ala Asp Lys 
    1220                 1225                 1230             


Ser Pro  Xaa Pro Pro Asn Leu  Pro Ser Asp Lys Ile  Tyr Pro Pro 
    1235                 1240                 1245             


Ser Gly  Ser Pro Glu Glu Asn  Xaa Ser Xaa Ala Xaa  Met Xaa Tyr 
    1250                 1255                 1260             


Met Xaa  Xaa Xaa Pro Ala Xaa  Ala Gln Met Ser Xaa  Lys Glu Ala 
    1265                 1270                 1275             


Ser Trp  Asp Val Ala Glu Gln  Pro Xaa Xaa Ala Asp  Phe Ala Ala 
    1280                 1285                 1290             


Ala Xaa  Leu Gln Arg Xaa His  Arg Xaa Asn Arg Pro  Leu Pro Pro 
    1295                 1300                 1305             


Pro Pro  Ser Gln Arg Ser Ala  Glu Gln Pro Pro Val  Val Gly Gln 
    1310                 1315                 1320             


Val Gln  Ala Ala Xaa Asn Ile  Gly Leu Asn Asn Ser  His Lys Val 
    1325                 1330                 1335             


Gln Gly  Val Val Pro Val Pro  Glu Arg Pro Pro Glu  Pro Arg Ala 
    1340                 1345                 1350             


Met Asp  Asp Pro Ala Ser Ala  Phe Ile Ser Asp Ser  Gly Ala Ala 
    1355                 1360                 1365             


Ala Ala  Gln Cys Pro Met Ala  Xaa Ala Val Gln Pro  Gly Leu Pro 
    1370                 1375                 1380             


Glu Lys  Val Arg Asp Gly Ala  Arg Val Pro Leu Leu  His Leu Arg 
    1385                 1390                 1395             


Ala Glu  Ser Val Pro Ala His  Pro Cys Gly Phe Pro  Ala Pro Leu 
    1400                 1405                 1410             


Pro Pro  Xaa Arg Met Met Glu  Ser Lys Met Ile Ala  Ala Ile His 
    1415                 1420                 1425             


Ser Ser  Ser Ala Asp Ala Xaa  Ser Ser Ser Asn Tyr  His Ser Phe 
    1430                 1435                 1440             


Val Xaa  Ala Ser Ser Xaa Ser  Val Asp Asp Ala Leu  Pro Leu Pro 
    1445                 1450                 1455             


Leu Pro  Val Pro Gln Pro Lys  His Ala Ser Gln Lys  Xaa Val Tyr 
    1460                 1465                 1470             


Ser Ser  Phe Ala Arg Pro Asp  Val Xaa Xaa Glu Pro  Phe Gly Pro 
    1475                 1480                 1485             


Asp Asn  Cys Leu His Phe Asn  Met Xaa Pro Asn Cys  Gln Tyr Arg 
    1490                 1495                 1500             


Pro Gln  Ser Val Pro Pro His  His Asn Lys Leu Glu  Gln His Gln 
    1505                 1510                 1515             


Val Tyr  Gly Ala Arg Ser Glu  Pro Pro Ala Ser Met  Gly Leu Arg 
    1520                 1525                 1530             


Tyr Asn  Xaa Tyr Val Ala Pro  Gly Arg Asn Ala Ser  Gly His His 
    1535                 1540                 1545             


Ser Lys  Pro Cys Ser Arg Val  Glu Tyr Val Ser Ser  Leu Ser Ser 
    1550                 1555                 1560             


Ser Val  Arg Asn Xaa Cys Tyr  Pro Glu Asp Ile Pro  Pro Tyr Pro 
    1565                 1570                 1575             


Xaa Ile  Arg Arg Val Gln Ser  Leu His Ala Pro Pro  Ser Ser Met 
    1580                 1585                 1590             


Ile Arg  Ser Val Pro Ile Ser  Arg Xaa Glu Val Pro  Pro Asp Asp 
    1595                 1600                 1605             


Glu Pro  Ala Tyr Cys Pro Arg  Pro Leu Tyr Gln Tyr  Lys Pro Tyr 
    1610                 1615                 1620             


Gln Ser  Ser Gln Ala Arg Ser  Asp Tyr His Val Xaa  Gln Leu Gln 
    1625                 1630                 1635             


Pro Tyr  Phe Glu Asn Gly Arg  Val His Tyr Arg Tyr  Ser Pro Tyr 
    1640                 1645                 1650             


Ser Ser  Ser Ser Ser Ser Tyr  Tyr Ser Pro Asp Gly  Ala Leu Cys 
    1655                 1660                 1665             


Asp Val  Asp Ala Tyr Gly Xaa  Val Gln Leu Arg Pro  Leu His Arg 
    1670                 1675                 1680             


Leu Pro  Asn Arg Asp Phe Ala  Phe Tyr Asn Pro Arg  Leu Gln Gly 
    1685                 1690                 1695             


Lys Ser  Leu Tyr Ser Tyr Ala  Gly Leu Ala Pro Arg  Pro Arg Ala 
    1700                 1705                 1710             


Asn Val  Xaa Gly Tyr Phe Ser  Pro Asn Asp His Asn  Val Val Ser 
    1715                 1720                 1725             


Met Pro  Pro Ala Ala Asp Val  Lys His Xaa Tyr Xaa  Ser Trp Asp 
    1730                 1735                 1740             


Leu Glu  Asp Met Glu Lys Tyr  Arg Met Gln Ser Ile  Arg Arg Glu 
    1745                 1750                 1755             


Ser Arg  Ala Arg Gln Lys Val  Lys Gly Pro Val Met  Ser Gln Tyr 
    1760                 1765                 1770             


Asp Asn  Met Xaa Pro Ala Val  Gln Asp Asp Leu Gly  Gly Ile Tyr 
    1775                 1780                 1785             


Val Ile  His Leu Arg Ser Lys  Ser Asp Pro Gly Lys  Xaa Gly Leu 
    1790                 1795                 1800             


Leu Ser  Val Ala Glu Gly Lys  Glu Ser Arg His Ala  Ala Lys Ala 
    1805                 1810                 1815             


Ile Ser  Pro Glu Gly Glu Asp  Arg Phe Tyr Arg Arg  His Pro Glu 
    1820                 1825                 1830             


Ala Glu  Met Asp Arg Ala His  His His Gly Gly His  Gly Ser Xaa 
    1835                 1840                 1845             


Gln Pro  Glu Lys Pro Ser Leu  Pro Gln Lys Gln Ser  Ser Leu Arg 
    1850                 1855                 1860             


Ser Arg  Lys Leu Pro Asp Met  Gly Cys Ser Leu Pro  Glu His Arg 
    1865                 1870                 1875             


Ala His  Gln Glu Ala Ser His  Arg Gln Phe Cys Glu  Ser Lys Asn 
    1880                 1885                 1890             


Gly Pro  Pro Tyr Pro Gln Gly  Ala Gly Gln Leu Asp  Tyr Gly Ser 
    1895                 1900                 1905             


Lys Gly  Ile Pro Asp Xaa Ser  Glu Pro Val Ser Tyr  His Asn Ser 
    1910                 1915                 1920             


Gly Val  Lys Tyr Ala Ala Ser  Gly Gln Glu Ser Leu  Arg Leu Asn 
    1925                 1930                 1935             


His Lys  Glu Val Arg Leu Ser  Lys Glu Met Glu Arg  Pro Trp Val 
    1940                 1945                 1950             


Arg Gln  Pro Ser Ala Pro Glu  Lys His Ser Arg Asp  Cys Tyr Lys 
    1955                 1960                 1965             


Glu Glu  Glu His Leu Xaa Gln  Ser Ile Val Pro Pro  Pro Lys Pro 
    1970                 1975                 1980             


Glu Arg  Ser His Ser Leu Lys  Leu His His Xaa Gln  Asn Val Glu 
    1985                 1990                 1995             


Arg Asp  Pro Ser Val Leu Tyr  Gln Tyr Gln Pro His  Gly Lys Arg 
    2000                 2005                 2010             


Gln Ser  Ser Val Xaa Val Val  Ser Gln Tyr Asp Asn  Leu Glu Asp 
    2015                 2020                 2025             


Tyr His  Ser Leu Pro Gln His  Gln Arg Gly Val Phe  Gly Gly Gly 
    2030                 2035                 2040             


Gly Met  Gly Xaa Tyr Val Pro  Pro Gly Phe Pro His  Pro Gln Ser 
    2045                 2050                 2055             


Arg Xaa  Tyr Ala Xaa Ala Leu  Gly Gln Gly Ala Phe  Leu Pro Ala 
    2060                 2065                 2070             


Glu Leu  Ser Leu Gln His Pro  Glu Xaa Gln Ile His  Ala Glu 
    2075                 2080                 2085         


<210> 2836
<211> 1738
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1187)..(1187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1253)..(1253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1367)..(1367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1391)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1428)..(1428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1452)..(1452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1499)..(1499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1565)..(1565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1625)..(1625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1645)..(1645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1669)..(1669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1698)..(1698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1711)..(1711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1714)..(1714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1733)..(1733)
<223> Selenocysteine

<400> 2836
Met Lys Ser Arg Pro Xaa Lys Gln Lys Leu Lys Gln Arg Gly Ile Leu 
1               5                   10                  15      


Lys Glu Arg Val Phe Gly Cys Asp Leu Gly Glu His Leu Leu Asn Ser 
            20                  25                  30          


Gly Phe Glu Val Pro Gln Val Leu Gln Ser Cys Xaa Ala Phe Ile Glu 
        35                  40                  45              


Arg Tyr Gly Ile Val Asp Gly Ile Tyr Arg Leu Ser Gly Val Ala Ser 
    50                  55                  60                  


Asn Ile Gln Arg Leu Arg His Glu Phe Asp Ser Glu His Val Pro Asp 
65                  70                  75                  80  


Leu Xaa Lys Glu Pro Tyr Val Gln Asp Ile His Ser Val Gly Ser Leu 
                85                  90                  95      


Cys Lys Leu Tyr Phe Arg Glu Leu Pro Asn Pro Leu Leu Xaa Tyr Gln 
            100                 105                 110         


Leu Tyr Glu Lys Phe Ser Asp Ala Val Ser Ala Ala Xaa Asp Glu Glu 
        115                 120                 125             


Arg Leu Ile Lys Ile His Asp Val Ile Gln Gln Leu Pro Pro Pro His 
    130                 135                 140                 


Tyr Arg Xaa Leu Glu Phe Leu Met Arg His Leu Ser Leu Leu Ala Asp 
145                 150                 155                 160 


Tyr Cys Ser Ile Xaa Asn Met His Ala Lys Asn Leu Ala Ile Val Trp 
                165                 170                 175     


Ala Pro Asn Leu Leu Arg Ser Lys Gln Ile Glu Ser Ala Cys Phe Ser 
            180                 185                 190         


Gly Xaa Ala Ala Phe Met Glu Val Arg Ile Gln Ser Val Val Val Glu 
        195                 200                 205             


Phe Ile Leu Asn His Val Asp Val Leu Phe Ser Gly Arg Ile Ser Met 
    210                 215                 220                 


Ala Met Gln Glu Gly Ala Ala Ser Leu Ser Arg Pro Lys Ser Leu Leu 
225                 230                 235                 240 


Val Ser Ser Pro Ser Xaa Lys Leu Leu Xaa Leu Glu Glu Ala Gln Ala 
                245                 250                 255     


Arg Xaa Gln Ala Gln Val Asn Ser Pro Ile Val Xaa Glu Asn Lys Tyr 
            260                 265                 270         


Ile Glu Val Gly Glu Gly Pro Ala Ala Leu Gln Gly Lys Phe His Xaa 
        275                 280                 285             


Ile Ile Glu Phe Pro Leu Glu Arg Lys Arg Pro Gln Asn Lys Met Lys 
    290                 295                 300                 


Lys Ser Pro Val Gly Ser Trp Arg Ser Phe Phe Asn Leu Gly Lys Ser 
305                 310                 315                 320 


Ser Ser Val Ser Lys Arg Lys Leu Gln Arg Asn Glu Ser Glu Pro Ser 
                325                 330                 335     


Glu Met Lys Ala Met Ala Leu Lys Gly Gly Arg Ala Glu Gly Xaa Leu 
            340                 345                 350         


Arg Ser Ala Lys Ser Glu Glu Ser Leu Xaa Ser Leu His Ala Val Asp 
        355                 360                 365             


Gly Asp Ser Lys Leu Phe Arg Pro Arg Arg Pro Arg Ser Ser Ser Asp 
    370                 375                 380                 


Ala Leu Ser Ala Ser Phe Asn Gly Glu Met Leu Gly Asn Arg Cys Asn 
385                 390                 395                 400 


Ser Tyr Asp Asn Leu Pro His Asp Asn Glu Ser Glu Glu Glu Gly Gly 
                405                 410                 415     


Leu Leu His Ile Pro Ala Leu Met Ser Pro His Ser Ala Glu Asp Val 
            420                 425                 430         


Asp Leu Ser Pro Pro Asp Ile Gly Val Ala Ser Leu Asp Phe Asp Pro 
        435                 440                 445             


Met Ser Phe Gln Cys Ser Pro Pro Lys Ala Glu Ser Glu Cys Leu Glu 
    450                 455                 460                 


Ser Gly Ala Ser Phe Leu Asp Ser Pro Gly Tyr Ser Lys Asp Lys Pro 
465                 470                 475                 480 


Ser Ala Asn Lys Lys Asp Ala Glu Xaa Gly Ser Ser Gln Cys Gln Xaa 
                485                 490                 495     


Pro Gly Ser Xaa Ala Ser Ser Glu Pro Val Ser Pro Leu Gln Glu Lys 
            500                 505                 510         


Leu Ser Pro Phe Phe Xaa Leu Asp Leu Ser Pro Xaa Glu Asp Lys Ser 
        515                 520                 525             


Ser Lys Pro Ser Ser Phe Xaa Glu Lys Val Val Tyr Ala Phe Ser Pro 
    530                 535                 540                 


Lys Ile Gly Arg Lys Leu Ser Lys Ser Pro Ser Met Ser Ile Ser Glu 
545                 550                 555                 560 


Pro Ile Ser Val Xaa Leu Pro Pro Arg Val Ser Glu Val Ile Gly Xaa 
                565                 570                 575     


Val Ser Asn Xaa Xaa Ala Gln Asn Ala Ser Ser Ser Xaa Trp Asp Lys 
            580                 585                 590         


Cys Val Glu Glu Arg Asp Ala Xaa Asn Arg Ser Pro Xaa Gln Ile Val 
        595                 600                 605             


Lys Met Lys Xaa Asn Glu Xaa Val Ala Gln Glu Ala Tyr Glu Ser Glu 
    610                 615                 620                 


Val Gln Pro Leu Asp Gln Val Ala Ala Glu Glu Val Glu Leu Pro Gly 
625                 630                 635                 640 


Lys Glu Asp Gln Ser Val Ser Ser Ser Gln Ser Lys Ala Val Ala Ser 
                645                 650                 655     


Gly Gln Xaa Gln Xaa Gly Ala Val Xaa His Asp Pro Pro Gln Asp Ser 
            660                 665                 670         


Val Pro Val Ser Ser Val Ser Leu Ile Pro Pro Pro Pro Pro Pro Lys 
        675                 680                 685             


Asn Val Ala Arg Met Leu Ala Leu Ala Leu Ala Glu Ser Ala Gln Gln 
    690                 695                 700                 


Ala Ser Xaa Gln Ser Leu Lys Arg Pro Gly Xaa Ser Gln Ala Gly Tyr 
705                 710                 715                 720 


Xaa Asn Tyr Gly Asp Ile Ala Val Ala Xaa Xaa Glu Asp Asn Leu Ser 
                725                 730                 735     


Ser Ser Tyr Ser Ala Val Ala Leu Asp Lys Ala Tyr Phe Gln Xaa Asp 
            740                 745                 750         


Arg Pro Ala Glu Gln Phe His Leu Gln Asn Asn Ala Pro Gly Asn Cys 
        755                 760                 765             


Asp His Pro Leu Pro Glu Xaa Xaa Ala Xaa Gly Asp Pro Xaa His Ser 
    770                 775                 780                 


Asn Xaa Xaa Glu Ser Gly Glu Gln His His Gln Val Asp Leu Xaa Gly 
785                 790                 795                 800 


Asn Gln Pro His Gln Ala Tyr Leu Ser Gly Asp Pro Glu Lys Ala Arg 
                805                 810                 815     


Ile Xaa Ser Val Pro Leu Asp Ser Glu Lys Ser Asp Asp His Val Ser 
            820                 825                 830         


Phe Pro Glu Asp Gln Ser Gly Lys Asn Ser Met Pro Xaa Val Ser Phe 
        835                 840                 845             


Leu Asp Gln Asp Gln Ser Pro Pro Arg Phe Tyr Ser Gly Asp Gln Pro 
    850                 855                 860                 


Pro Ser Tyr Leu Gly Ala Ser Val Asp Lys Leu His His Pro Leu Glu 
865                 870                 875                 880 


Phe Ala Asp Lys Ser Pro Xaa Pro Pro Asn Leu Pro Ser Asp Lys Ile 
                885                 890                 895     


Tyr Pro Pro Ser Gly Ser Pro Glu Glu Asn Xaa Ser Xaa Ala Xaa Met 
            900                 905                 910         


Xaa Tyr Met Xaa Xaa Xaa Pro Ala Xaa Ala Gln Met Ser Xaa Lys Glu 
        915                 920                 925             


Ala Ser Trp Asp Val Ala Glu Gln Pro Xaa Xaa Ala Asp Phe Ala Ala 
    930                 935                 940                 


Ala Xaa Leu Gln Arg Xaa His Arg Xaa Asn Arg Pro Leu Pro Pro Pro 
945                 950                 955                 960 


Pro Ser Gln Arg Ser Ala Glu Gln Pro Pro Val Val Gly Gln Val Gln 
                965                 970                 975     


Ala Ala Xaa Asn Ile Gly Leu Asn Asn Ser His Lys Val Gln Gly Val 
            980                 985                 990         


Val Pro Val Pro Glu Arg Pro Pro  Glu Pro Arg Ala Met  Asp Asp Pro 
        995                 1000                 1005             


Ala Ser  Ala Phe Ile Ser Asp  Ser Gly Ala Ala Ala  Ala Gln Cys 
    1010                 1015                 1020             


Pro Met  Ala Xaa Ala Val Gln  Pro Gly Leu Pro Glu  Lys Val Arg 
    1025                 1030                 1035             


Asp Gly  Ala Arg Val Pro Leu  Leu His Leu Arg Ala  Glu Ser Val 
    1040                 1045                 1050             


Pro Ala  His Pro Cys Gly Phe  Pro Ala Pro Leu Pro  Pro Xaa Arg 
    1055                 1060                 1065             


Met Met  Glu Ser Lys Met Ile  Ala Ala Ile His Ser  Ser Ser Ala 
    1070                 1075                 1080             


Asp Ala  Xaa Ser Ser Ser Asn  Tyr His Ser Phe Val  Xaa Ala Ser 
    1085                 1090                 1095             


Ser Xaa  Ser Val Asp Asp Ala  Leu Pro Leu Pro Leu  Pro Val Pro 
    1100                 1105                 1110             


Gln Pro  Lys His Ala Ser Gln  Lys Xaa Val Tyr Ser  Ser Phe Ala 
    1115                 1120                 1125             


Arg Pro  Asp Val Xaa Xaa Glu  Pro Phe Gly Pro Asp  Asn Cys Leu 
    1130                 1135                 1140             


His Phe  Asn Met Xaa Pro Asn  Cys Gln Tyr Arg Pro  Gln Ser Val 
    1145                 1150                 1155             


Pro Pro  His His Asn Lys Leu  Glu Gln His Gln Val  Tyr Gly Ala 
    1160                 1165                 1170             


Arg Ser  Glu Pro Pro Ala Ser  Met Gly Leu Arg Tyr  Asn Xaa Tyr 
    1175                 1180                 1185             


Val Ala  Pro Gly Arg Asn Ala  Ser Gly His His Ser  Lys Pro Cys 
    1190                 1195                 1200             


Ser Arg  Val Glu Tyr Val Ser  Ser Leu Ser Ser Ser  Val Arg Asn 
    1205                 1210                 1215             


Xaa Cys  Tyr Pro Glu Asp Ile  Pro Pro Tyr Pro Xaa  Ile Arg Arg 
    1220                 1225                 1230             


Val Gln  Ser Leu His Ala Pro  Pro Ser Ser Met Ile  Arg Ser Val 
    1235                 1240                 1245             


Pro Ile  Ser Arg Xaa Glu Val  Pro Pro Asp Asp Glu  Pro Ala Tyr 
    1250                 1255                 1260             


Cys Pro  Arg Pro Leu Tyr Gln  Tyr Lys Pro Tyr Gln  Ser Ser Gln 
    1265                 1270                 1275             


Ala Arg  Ser Asp Tyr His Val  Xaa Gln Leu Gln Pro  Tyr Phe Glu 
    1280                 1285                 1290             


Asn Gly  Arg Val His Tyr Arg  Tyr Ser Pro Tyr Ser  Ser Ser Ser 
    1295                 1300                 1305             


Ser Ser  Tyr Tyr Ser Pro Asp  Gly Ala Leu Cys Asp  Val Asp Ala 
    1310                 1315                 1320             


Tyr Gly  Xaa Val Gln Leu Arg  Pro Leu His Arg Leu  Pro Asn Arg 
    1325                 1330                 1335             


Asp Phe  Ala Phe Tyr Asn Pro  Arg Leu Gln Gly Lys  Ser Leu Tyr 
    1340                 1345                 1350             


Ser Tyr  Ala Gly Leu Ala Pro  Arg Pro Arg Ala Asn  Val Xaa Gly 
    1355                 1360                 1365             


Tyr Phe  Ser Pro Asn Asp His  Asn Val Val Ser Met  Pro Pro Ala 
    1370                 1375                 1380             


Ala Asp  Val Lys His Xaa Tyr  Xaa Ser Trp Asp Leu  Glu Asp Met 
    1385                 1390                 1395             


Glu Lys  Tyr Arg Met Gln Ser  Ile Arg Arg Glu Ser  Arg Ala Arg 
    1400                 1405                 1410             


Gln Lys  Val Lys Gly Pro Val  Met Ser Gln Tyr Asp  Asn Met Xaa 
    1415                 1420                 1425             


Pro Ala  Val Gln Asp Asp Leu  Gly Gly Ile Tyr Val  Ile His Leu 
    1430                 1435                 1440             


Arg Ser  Lys Ser Asp Pro Gly  Lys Xaa Gly Leu Leu  Ser Val Ala 
    1445                 1450                 1455             


Glu Gly  Lys Glu Ser Arg His  Ala Ala Lys Ala Ile  Ser Pro Glu 
    1460                 1465                 1470             


Gly Glu  Asp Arg Phe Tyr Arg  Arg His Pro Glu Ala  Glu Met Asp 
    1475                 1480                 1485             


Arg Ala  His His His Gly Gly  His Gly Ser Xaa Gln  Pro Glu Lys 
    1490                 1495                 1500             


Pro Ser  Leu Pro Gln Lys Gln  Ser Ser Leu Arg Ser  Arg Lys Leu 
    1505                 1510                 1515             


Pro Asp  Met Gly Cys Ser Leu  Pro Glu His Arg Ala  His Gln Glu 
    1520                 1525                 1530             


Ala Ser  His Arg Gln Phe Cys  Glu Ser Lys Asn Gly  Pro Pro Tyr 
    1535                 1540                 1545             


Pro Gln  Gly Ala Gly Gln Leu  Asp Tyr Gly Ser Lys  Gly Ile Pro 
    1550                 1555                 1560             


Asp Xaa  Ser Glu Pro Val Ser  Tyr His Asn Ser Gly  Val Lys Tyr 
    1565                 1570                 1575             


Ala Ala  Ser Gly Gln Glu Ser  Leu Arg Leu Asn His  Lys Glu Val 
    1580                 1585                 1590             


Arg Leu  Ser Lys Glu Met Glu  Arg Pro Trp Val Arg  Gln Pro Ser 
    1595                 1600                 1605             


Ala Pro  Glu Lys His Ser Arg  Asp Cys Tyr Lys Glu  Glu Glu His 
    1610                 1615                 1620             


Leu Xaa  Gln Ser Ile Val Pro  Pro Pro Lys Pro Glu  Arg Ser His 
    1625                 1630                 1635             


Ser Leu  Lys Leu His His Xaa  Gln Asn Val Glu Arg  Asp Pro Ser 
    1640                 1645                 1650             


Val Leu  Tyr Gln Tyr Gln Pro  His Gly Lys Arg Gln  Ser Ser Val 
    1655                 1660                 1665             


Xaa Val  Val Ser Gln Tyr Asp  Asn Leu Glu Asp Tyr  His Ser Leu 
    1670                 1675                 1680             


Pro Gln  His Gln Arg Gly Val  Phe Gly Gly Gly Gly  Met Gly Xaa 
    1685                 1690                 1695             


Tyr Val  Pro Pro Gly Phe Pro  His Pro Gln Ser Arg  Xaa Tyr Ala 
    1700                 1705                 1710             


Xaa Ala  Leu Gly Gln Gly Ala  Phe Leu Pro Ala Glu  Leu Ser Leu 
    1715                 1720                 1725             


Gln His  Pro Glu Xaa Gln Ile  His Ala Glu 
    1730                 1735             


<210> 2837
<211> 178
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<400> 2837
Met Lys Ser Ser Val His Ser Glu Glu Asp Asp Phe Val Pro Glu Leu 
1               5                   10                  15      


His Arg Asn Val His Pro Arg Glu Arg Pro Asp Trp Glu Glu Xaa Leu 
            20                  25                  30          


Ser Ala Met Ala Arg Gly Ala Asp Val Pro Glu Ile Pro Gly Asp Leu 
        35                  40                  45              


Xaa Leu Lys Xaa Cys Gly Ser Xaa Ala Ser Met Lys Val Lys His Val 
    50                  55                  60                  


Lys Lys Ser Xaa Xaa Pro Gly Leu Met Gly Cys Asp Asn Ile His Arg 
65                  70                  75                  80  


Leu Pro Phe Xaa Lys Gly His Phe Pro Lys Met Ala Glu Cys Ala His 
                85                  90                  95      


Phe His Tyr Glu Asn Val Glu Phe Gly Ser Ile Gln Leu Ser Leu Ser 
            100                 105                 110         


Glu Glu Gln Asn Glu Val Met Lys Asn Gly Cys Glu Ser Lys Glu Leu 
        115                 120                 125             


Val Tyr Leu Val Gln Ile Ala Cys Gln Gly Lys Ser Trp Ile Val Lys 
    130                 135                 140                 


Arg Ser Tyr Glu Asp Phe Arg Val Leu Asp Lys His Leu His Leu Cys 
145                 150                 155                 160 


Ile Tyr Asp Arg Arg Phe Ser Gln Leu Ser Glu Leu Pro Arg Ser Asp 
                165                 170                 175     


Xaa Leu 
        


<210> 2838
<211> 1123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1108)..(1108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<400> 2838
Met Leu Val Pro Leu Leu Leu Gln Tyr Leu Glu Xaa Leu Ser Gly Leu 
1               5                   10                  15      


Val Asp Ser Asn Leu Asn Cys Gly Pro Val Leu Xaa Trp Met Glu Leu 
            20                  25                  30          


Asp Asn His Gly Arg Arg Leu Leu Leu Ser Glu Glu Ala Ser Leu Asn 
        35                  40                  45              


Ile Pro Ala Val Ala Ala Ala His Val Ile Lys Arg Tyr Xaa Ala Gln 
    50                  55                  60                  


Ala Pro Asp Glu Leu Ser Phe Glu Val Gly Asp Ile Val Ser Val Ile 
65                  70                  75                  80  


Asp Met Pro Pro Xaa Glu Asp Arg Ser Trp Trp Arg Gly Lys Arg Gly 
                85                  90                  95      


Phe Gln Val Gly Phe Phe Pro Ser Glu Cys Val Glu Leu Phe Xaa Glu 
            100                 105                 110         


Arg Pro Gly Pro Gly Leu Lys Ala Asp Ala Asp Gly Pro Pro Cys Gly 
        115                 120                 125             


Ile Pro Ala Pro Gln Gly Ile Ser Ser Leu Xaa Ser Ala Val Pro Arg 
    130                 135                 140                 


Pro Arg Gly Lys Leu Ala Gly Leu Leu Arg Xaa Phe Met Arg Ser Arg 
145                 150                 155                 160 


Pro Ser Arg Gln Arg Leu Arg Gln Arg Gly Ile Leu Arg Gln Arg Val 
                165                 170                 175     


Phe Gly Cys Asp Leu Gly Glu His Leu Ser Asn Ser Gly Gln Asp Val 
            180                 185                 190         


Pro Gln Val Leu Arg Cys Cys Ser Glu Phe Ile Glu Ala His Gly Val 
        195                 200                 205             


Val Asp Gly Ile Tyr Arg Leu Ser Gly Val Ser Ser Asn Ile Gln Arg 
    210                 215                 220                 


Leu Arg His Glu Phe Asp Ser Glu Arg Ile Pro Glu Leu Ser Gly Pro 
225                 230                 235                 240 


Ala Phe Leu Gln Asp Ile His Ser Val Ser Ser Leu Cys Lys Leu Tyr 
                245                 250                 255     


Phe Arg Glu Leu Pro Asn Pro Leu Leu Xaa Tyr Gln Leu Tyr Gly Lys 
            260                 265                 270         


Phe Ser Glu Ala Met Ser Val Pro Gly Glu Glu Glu Arg Leu Val Arg 
        275                 280                 285             


Val His Asp Val Ile Gln Gln Leu Pro Pro Pro His Tyr Arg Xaa Leu 
    290                 295                 300                 


Glu Tyr Leu Leu Arg His Leu Ala Arg Met Ala Arg His Ser Ala Asn 
305                 310                 315                 320 


Xaa Ser Met His Ala Arg Asn Leu Ala Ile Val Trp Ala Pro Asn Leu 
                325                 330                 335     


Leu Arg Ser Met Glu Leu Glu Ser Val Gly Met Gly Gly Ala Ala Ala 
            340                 345                 350         


Phe Arg Glu Val Arg Val Gln Ser Val Val Val Glu Phe Leu Leu Xaa 
        355                 360                 365             


His Val Asp Val Leu Phe Ser Asp Xaa Phe Xaa Ser Ala Gly Leu Asp 
    370                 375                 380                 


Pro Ala Gly Arg Cys Leu Leu Pro Arg Pro Lys Ser Leu Ala Gly Ser 
385                 390                 395                 400 


Cys Pro Ser Xaa Arg Leu Leu Xaa Leu Glu Glu Ala Gln Ala Arg Xaa 
                405                 410                 415     


Gln Gly Arg Leu Gly Xaa Pro Xaa Glu Pro Xaa Xaa Pro Lys Ala Pro 
            420                 425                 430         


Ala Ser Pro Ala Glu Arg Arg Lys Gly Glu Arg Gly Glu Lys Gln Arg 
        435                 440                 445             


Lys Pro Gly Gly Ser Ser Trp Lys Xaa Phe Phe Ala Leu Gly Arg Gly 
    450                 455                 460                 


Pro Ser Val Pro Arg Lys Lys Pro Leu Pro Trp Leu Gly Gly Xaa Arg 
465                 470                 475                 480 


Ala Pro Pro Gln Pro Ser Gly Ser Arg Pro Asp Xaa Val Xaa Leu Arg 
                485                 490                 495     


Ser Ala Lys Ser Glu Glu Ser Leu Ser Ser Gln Ala Ser Gly Ala Gly 
            500                 505                 510         


Leu Gln Arg Leu His Arg Leu Arg Arg Pro His Ser Ser Ser Asp Ala 
        515                 520                 525             


Phe Pro Val Gly Pro Ala Pro Ala Gly Ser Cys Glu Ser Leu Ser Ser 
    530                 535                 540                 


Ser Ser Ser Ser Glu Ser Ser Ser Ser Glu Ser Ser Ser Ser Ser Ser 
545                 550                 555                 560 


Glu Ser Ser Ala Ala Gly Leu Gly Ala Leu Ser Gly Ser Pro Ser His 
                565                 570                 575     


Arg Xaa Ser Ala Trp Leu Asp Asp Gly Asp Glu Leu Asp Phe Ser Pro 
            580                 585                 590         


Pro Arg Cys Leu Glu Gly Leu Arg Gly Leu Asp Phe Asp Pro Leu Xaa 
        595                 600                 605             


Phe Arg Cys Ser Ser Pro Xaa Pro Gly Asp Pro Ala Pro Pro Ala Ser 
    610                 615                 620                 


Pro Ala Pro Pro Ala Pro Ala Ser Ala Phe Pro Pro Arg Val Xaa Pro 
625                 630                 635                 640 


Gln Ala Ile Ser Pro Arg Gly Pro Xaa Ser Pro Ala Ser Pro Ala Ala 
                645                 650                 655     


Leu Asp Ile Ser Glu Pro Leu Ala Val Ser Val Pro Pro Ala Val Leu 
            660                 665                 670         


Glu Leu Leu Gly Ala Gly Gly Ala Pro Ala Ser Ala Xaa Pro Xaa Pro 
        675                 680                 685             


Ala Leu Ser Pro Gly Arg Ser Leu Arg Pro His Leu Ile Pro Leu Leu 
    690                 695                 700                 


Leu Arg Gly Ala Glu Ala Pro Leu Xaa Asp Ala Cys Gln Gln Glu Met 
705                 710                 715                 720 


Cys Ser Lys Leu Arg Gly Ala Gln Gly Pro Leu Gly Pro Asp Met Glu 
                725                 730                 735     


Ser Pro Leu Pro Pro Pro Pro Leu Ser Leu Leu Arg Pro Gly Gly Ala 
            740                 745                 750         


Pro Pro Pro Pro Pro Lys Asn Pro Ala Arg Leu Met Ala Leu Ala Leu 
        755                 760                 765             


Ala Glu Arg Ala Gln Gln Val Ala Glu Gln Gln Ser Gln Gln Glu Cys 
    770                 775                 780                 


Gly Gly Xaa Pro Pro Ala Ser Gln Ser Pro Phe His Arg Ser Leu Ser 
785                 790                 795                 800 


Leu Glu Val Gly Gly Glu Pro Leu Gly Xaa Ser Gly Ser Gly Pro Pro 
                805                 810                 815     


Pro Asn Ser Leu Ala His Pro Gly Ala Trp Val Pro Gly Pro Pro Pro 
            820                 825                 830         


Tyr Leu Pro Arg Gln Gln Ser Asp Gly Ser Leu Leu Arg Ser Gln Arg 
        835                 840                 845             


Pro Met Gly Xaa Ser Arg Arg Gly Leu Arg Gly Pro Ala Gln Val Pro 
    850                 855                 860                 


Xaa Pro Gly Phe Phe Ser Pro Ala Pro Arg Glu Cys Leu Pro Pro Phe 
865                 870                 875                 880 


Leu Gly Val Pro Lys Pro Gly Leu Tyr Pro Leu Gly Pro Pro Ser Phe 
                885                 890                 895     


Gln Pro Ser Ser Pro Ala Pro Val Trp Arg Ser Ser Leu Gly Pro Pro 
            900                 905                 910         


Ala Pro Leu Asp Arg Gly Glu Asn Leu Tyr Tyr Glu Ile Gly Ala Ser 
        915                 920                 925             


Glu Gly Ser Pro Tyr Ser Gly Pro Xaa Arg Ser Trp Ser Pro Phe Arg 
    930                 935                 940                 


Ser Met Pro Pro Asp Arg Leu Asn Ala Ser Tyr Gly Met Leu Gly Gln 
945                 950                 955                 960 


Ser Pro Pro Leu His Arg Ser Pro Asp Phe Leu Leu Ser Tyr Pro Pro 
                965                 970                 975     


Ala Pro Ser Cys Phe Pro Pro Asp His Leu Gly Tyr Ser Ala Pro Gln 
            980                 985                 990         


His Pro Ala Arg Arg Pro Xaa Pro  Pro Glu Pro Leu Tyr  Val Asn Leu 
        995                 1000                 1005             


Ala Leu  Gly Pro Arg Gly Pro  Ser Pro Ala Ser Ser  Ser Ser Ser 
    1010                 1015                 1020             


Ser Pro  Pro Ala His Pro Arg  Ser Arg Ser Asp Pro  Gly Pro Pro 
    1025                 1030                 1035             


Val Pro  Arg Leu Pro Gln Lys  Gln Arg Ala Pro Trp  Gly Pro Arg 
    1040                 1045                 1050             


Xaa Pro  His Arg Val Pro Gly  Pro Trp Gly Pro Pro  Glu Pro Leu 
    1055                 1060                 1065             


Leu Leu  Tyr Arg Ala Ala Pro  Pro Ala Tyr Gly Arg  Gly Gly Glu 
    1070                 1075                 1080             


Leu His  Arg Gly Ser Leu Tyr  Arg Asn Gly Gly Gln  Arg Gly Glu 
    1085                 1090                 1095             


Gly Ala  Gly Pro Pro Pro Pro  Tyr Pro Xaa Pro Ser  Trp Ser Leu 
    1100                 1105                 1110             


His Ser  Glu Gly Gln Xaa Arg  Ser Tyr Cys 
    1115                 1120             


<210> 2839
<211> 98
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 2839
Met Val Ala Arg Ser Xaa Asp Ser Leu Asp Gly Pro Gly Glu Gly Ser 
1               5                   10                  15      


Val Gln Pro Leu Pro Xaa Ala Gly Gly Pro Ser Val Lys Gly Lys Pro 
            20                  25                  30          


Gly Lys Arg Leu Ser Ala Pro Arg Gly Pro Phe Pro Arg Leu Ala Asp 
        35                  40                  45              


Cys Ala His Phe His Tyr Glu Asn Val Asp Phe Gly His Ile Gln Leu 
    50                  55                  60                  


Leu Leu Ser Pro Asp Arg Glu Gly Pro Ser Leu Ser Gly Glu Asn Glu 
65                  70                  75                  80  


Leu Val Phe Gly Val Gln Val Xaa Cys Gln Cys Glu Ile Ile Lys Ala 
                85                  90                  95      


Ala Gly 
        


<210> 2840
<211> 748
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<400> 2840
Met Val Ala Arg Ser Xaa Asp Ser Leu Asp Gly Pro Gly Glu Gly Ser 
1               5                   10                  15      


Val Gln Pro Leu Pro Xaa Ala Gly Gly Pro Ser Val Lys Gly Lys Pro 
            20                  25                  30          


Gly Lys Arg Leu Ser Ala Pro Arg Gly Pro Phe Pro Arg Leu Ala Asp 
        35                  40                  45              


Cys Ala His Phe His Tyr Glu Asn Val Asp Phe Gly His Ile Gln Leu 
    50                  55                  60                  


Leu Leu Ser Pro Asp Arg Glu Gly Pro Ser Leu Ser Gly Glu Asn Glu 
65                  70                  75                  80  


Leu Val Phe Gly Val Gln Val Xaa Cys Gln Gly Arg Ser Trp Pro Val 
                85                  90                  95      


Leu Arg Ser Tyr Asp Asp Phe Arg Ser Leu Asp Ala His Leu His Arg 
            100                 105                 110         


Cys Ile Phe Asp Arg Arg Phe Ser Cys Leu Pro Glu Leu Pro Pro Pro 
        115                 120                 125             


Pro Glu Gly Ala Arg Ala Ala Gln Met Leu Val Pro Leu Leu Leu Gln 
    130                 135                 140                 


Tyr Leu Glu Xaa Leu Ser Gly Leu Val Asp Ser Asn Leu Asn Cys Gly 
145                 150                 155                 160 


Pro Val Leu Xaa Trp Met Glu Leu Asp Asn His Gly Arg Arg Leu Leu 
                165                 170                 175     


Leu Ser Glu Glu Ala Ser Leu Asn Ile Pro Ala Val Ala Ala Ala His 
            180                 185                 190         


Val Ile Lys Arg Tyr Xaa Ala Gln Ala Pro Asp Glu Leu Ser Phe Glu 
        195                 200                 205             


Val Gly Asp Ile Val Ser Val Ile Asp Met Pro Pro Xaa Glu Asp Arg 
    210                 215                 220                 


Ser Trp Trp Arg Gly Lys Arg Gly Phe Gln Val Gly Phe Phe Pro Ser 
225                 230                 235                 240 


Glu Cys Val Glu Leu Phe Xaa Glu Arg Pro Gly Pro Gly Leu Lys Ala 
                245                 250                 255     


Asp Ala Asp Gly Pro Pro Cys Gly Ile Pro Ala Pro Gln Gly Ile Ser 
            260                 265                 270         


Ser Leu Xaa Ser Ala Val Pro Arg Pro Arg Gly Lys Leu Ala Gly Leu 
        275                 280                 285             


Leu Arg Xaa Phe Met Arg Ser Arg Pro Ser Arg Gln Arg Leu Arg Gln 
    290                 295                 300                 


Arg Gly Ile Leu Arg Gln Arg Val Phe Gly Cys Asp Leu Gly Glu His 
305                 310                 315                 320 


Leu Ser Asn Ser Gly Gln Asp Val Pro Gln Val Leu Arg Cys Cys Ser 
                325                 330                 335     


Glu Phe Ile Glu Ala His Gly Val Val Asp Gly Ile Tyr Arg Leu Ser 
            340                 345                 350         


Gly Val Ser Ser Asn Ile Gln Arg Leu Arg His Glu Phe Asp Ser Glu 
        355                 360                 365             


Arg Ile Pro Glu Leu Ser Gly Pro Ala Phe Leu Gln Asp Ile His Ser 
    370                 375                 380                 


Val Ser Ser Leu Cys Lys Leu Tyr Phe Arg Glu Leu Pro Asn Pro Leu 
385                 390                 395                 400 


Leu Xaa Tyr Gln Leu Tyr Gly Lys Phe Ser Glu Ala Met Ser Val Pro 
                405                 410                 415     


Gly Glu Glu Glu Arg Leu Val Arg Val His Asp Val Ile Gln Gln Leu 
            420                 425                 430         


Pro Pro Pro His Tyr Arg Xaa Leu Glu Tyr Leu Leu Arg His Leu Ala 
        435                 440                 445             


Arg Met Ala Arg His Ser Ala Asn Xaa Ser Met His Ala Arg Asn Leu 
    450                 455                 460                 


Ala Ile Val Trp Ala Pro Asn Leu Leu Arg Ser Met Glu Leu Glu Ser 
465                 470                 475                 480 


Val Gly Met Gly Gly Ala Ala Ala Phe Arg Glu Val Arg Val Gln Ser 
                485                 490                 495     


Val Val Val Glu Phe Leu Leu Xaa His Val Asp Val Leu Phe Ser Asp 
            500                 505                 510         


Xaa Phe Xaa Ser Ala Gly Leu Asp Pro Ala Gly Arg Cys Leu Leu Pro 
        515                 520                 525             


Arg Pro Lys Ser Leu Ala Gly Ser Cys Pro Ser Xaa Arg Leu Leu Xaa 
    530                 535                 540                 


Leu Glu Glu Ala Gln Ala Arg Xaa Gln Gly Arg Leu Gly Xaa Pro Xaa 
545                 550                 555                 560 


Glu Pro Xaa Xaa Pro Lys Ala Pro Ala Ser Pro Ala Glu Arg Arg Lys 
                565                 570                 575     


Gly Glu Arg Gly Glu Lys Gln Arg Lys Pro Gly Gly Ser Ser Trp Lys 
            580                 585                 590         


Xaa Phe Phe Ala Leu Gly Arg Gly Pro Ser Val Pro Arg Lys Lys Pro 
        595                 600                 605             


Leu Pro Trp Leu Gly Gly Xaa Arg Ala Pro Pro Gln Pro Ser Gly Ser 
    610                 615                 620                 


Arg Pro Asp Xaa Val Xaa Leu Arg Ser Ala Lys Ser Glu Glu Ser Leu 
625                 630                 635                 640 


Ser Ser Gln Ala Ser Gly Ala Gly Leu Gln Arg Leu His Arg Leu Arg 
                645                 650                 655     


Arg Pro His Ser Ser Ser Asp Ala Phe Pro Val Gly Pro Ala Pro Ala 
            660                 665                 670         


Gly Ser Cys Glu Ser Leu Ser Ser Ser Ser Ser Ser Glu Ser Ser Ser 
        675                 680                 685             


Ser Glu Ser Ser Ser Ser Ser Ser Glu Ser Ser Ala Ala Gly Leu Gly 
    690                 695                 700                 


Ala Leu Ser Gly Ser Pro Ser His Arg Xaa Ser Ala Trp Leu Asp Asp 
705                 710                 715                 720 


Gly Asp Glu Leu Asp Phe Ser Pro Pro Arg Tyr Pro Xaa Pro Ser Trp 
                725                 730                 735     


Ser Leu His Ser Glu Gly Gln Xaa Arg Ser Tyr Cys 
            740                 745             


<210> 2841
<211> 1126
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<400> 2841
Met Val Ala Arg Ser Xaa Asp Ser Leu Asp Gly Pro Gly Glu Gly Ser 
1               5                   10                  15      


Val Gln Pro Leu Pro Xaa Ala Gly Gly Pro Ser Val Lys Gly Lys Pro 
            20                  25                  30          


Gly Lys Arg Leu Ser Ala Pro Arg Gly Pro Phe Pro Arg Leu Ala Asp 
        35                  40                  45              


Cys Ala His Phe His Tyr Glu Asn Val Asp Phe Gly His Ile Gln Leu 
    50                  55                  60                  


Leu Leu Ser Pro Asp Arg Glu Gly Pro Ser Leu Ser Gly Glu Asn Glu 
65                  70                  75                  80  


Leu Val Phe Gly Val Gln Val Xaa Cys Gln Gly Arg Ser Trp Pro Val 
                85                  90                  95      


Leu Arg Ser Tyr Asp Asp Phe Arg Ser Leu Asp Ala His Leu His Arg 
            100                 105                 110         


Cys Ile Phe Asp Arg Arg Phe Ser Cys Leu Pro Glu Leu Pro Pro Pro 
        115                 120                 125             


Pro Glu Gly Ala Arg Ala Ala Gln Met Leu Val Pro Leu Leu Leu Gln 
    130                 135                 140                 


Tyr Leu Glu Xaa Leu Ser Gly Leu Val Asp Ser Asn Leu Asn Cys Gly 
145                 150                 155                 160 


Pro Val Leu Xaa Trp Met Glu Leu Asp Asn His Gly Arg Arg Leu Leu 
                165                 170                 175     


Leu Ser Glu Glu Ala Ser Leu Asn Ile Pro Ala Val Ala Ala Ala His 
            180                 185                 190         


Val Ile Lys Arg Tyr Xaa Ala Gln Ala Pro Asp Glu Leu Ser Phe Glu 
        195                 200                 205             


Val Gly Asp Ile Val Ser Val Ile Asp Met Pro Pro Xaa Glu Asp Arg 
    210                 215                 220                 


Ser Trp Trp Arg Gly Lys Arg Gly Phe Gln Val Gly Phe Phe Pro Ser 
225                 230                 235                 240 


Glu Cys Val Glu Leu Phe Xaa Glu Arg Pro Gly Pro Gly Leu Lys Ala 
                245                 250                 255     


Asp Ala Asp Gly Pro Pro Cys Gly Ile Pro Ala Pro Gln Gly Ile Ser 
            260                 265                 270         


Ser Leu Xaa Ser Ala Val Pro Arg Pro Arg Gly Lys Leu Ala Gly Leu 
        275                 280                 285             


Leu Arg Xaa Phe Met Arg Ser Arg Pro Ser Arg Gln Arg Leu Arg Gln 
    290                 295                 300                 


Arg Gly Ile Leu Arg Gln Arg Val Phe Gly Cys Asp Leu Gly Glu His 
305                 310                 315                 320 


Leu Ser Asn Ser Gly Gln Asp Val Pro Gln Val Leu Arg Cys Cys Ser 
                325                 330                 335     


Glu Phe Ile Glu Ala His Gly Val Val Asp Gly Ile Tyr Arg Leu Ser 
            340                 345                 350         


Gly Val Ser Ser Asn Ile Gln Arg Leu Arg His Glu Phe Asp Ser Glu 
        355                 360                 365             


Arg Ile Pro Glu Leu Ser Gly Pro Ala Phe Leu Gln Asp Ile His Ser 
    370                 375                 380                 


Val Ser Ser Leu Cys Lys Leu Tyr Phe Arg Glu Leu Pro Asn Pro Leu 
385                 390                 395                 400 


Leu Xaa Tyr Gln Leu Tyr Gly Lys Phe Ser Glu Ala Met Ser Val Pro 
                405                 410                 415     


Gly Glu Glu Glu Arg Leu Val Arg Val His Asp Val Ile Gln Gln Leu 
            420                 425                 430         


Pro Pro Pro His Tyr Arg Xaa Leu Glu Tyr Leu Leu Arg His Leu Ala 
        435                 440                 445             


Arg Met Ala Arg His Ser Ala Asn Xaa Ser Met His Ala Arg Asn Leu 
    450                 455                 460                 


Ala Ile Val Trp Ala Pro Asn Leu Leu Arg Ser Met Glu Leu Glu Ser 
465                 470                 475                 480 


Val Gly Met Gly Gly Ala Ala Ala Phe Arg Glu Val Arg Val Gln Ser 
                485                 490                 495     


Val Val Val Glu Phe Leu Leu Xaa His Val Asp Val Leu Phe Ser Asp 
            500                 505                 510         


Xaa Phe Xaa Ser Ala Gly Leu Asp Pro Ala Gly Arg Cys Leu Leu Pro 
        515                 520                 525             


Arg Pro Lys Ser Leu Ala Gly Ser Cys Pro Ser Xaa Arg Leu Leu Xaa 
    530                 535                 540                 


Leu Glu Glu Ala Gln Ala Arg Xaa Gln Gly Arg Leu Gly Xaa Pro Xaa 
545                 550                 555                 560 


Glu Pro Xaa Xaa Pro Lys Ala Pro Ala Ser Pro Ala Glu Arg Arg Lys 
                565                 570                 575     


Gly Glu Arg Gly Glu Lys Gln Arg Lys Pro Gly Gly Ser Ser Trp Lys 
            580                 585                 590         


Xaa Phe Phe Ala Leu Gly Arg Gly Pro Ser Val Pro Arg Lys Lys Pro 
        595                 600                 605             


Leu Pro Trp Leu Gly Gly Xaa Arg Ala Pro Pro Gln Pro Ser Gly Ser 
    610                 615                 620                 


Arg Pro Asp Xaa Val Xaa Leu Arg Ser Ala Lys Ser Glu Glu Ser Leu 
625                 630                 635                 640 


Ser Ser Gln Ala Ser Gly Ala Glu Leu Leu Gly Ala Gly Gly Ala Pro 
                645                 650                 655     


Ala Ser Ala Xaa Pro Xaa Pro Ala Leu Ser Pro Gly Arg Ser Leu Arg 
            660                 665                 670         


Pro His Leu Ile Pro Leu Leu Leu Arg Gly Ala Glu Ala Pro Leu Xaa 
        675                 680                 685             


Asp Ala Cys Gln Gln Glu Met Cys Ser Lys Leu Arg Gly Ala Gln Gly 
    690                 695                 700                 


Pro Leu Gly Pro Asp Met Glu Ser Pro Leu Pro Pro Pro Pro Leu Ser 
705                 710                 715                 720 


Leu Leu Arg Pro Gly Gly Ala Pro Pro Pro Pro Pro Lys Asn Pro Ala 
                725                 730                 735     


Arg Leu Met Ala Leu Ala Leu Ala Glu Arg Ala Gln Gln Val Ala Glu 
            740                 745                 750         


Gln Gln Ser Gln Gln Glu Cys Gly Gly Xaa Pro Pro Ala Ser Gln Ser 
        755                 760                 765             


Pro Phe His Arg Ser Leu Ser Leu Glu Val Gly Gly Glu Pro Leu Gly 
    770                 775                 780                 


Xaa Ser Gly Ser Gly Pro Pro Pro Asn Ser Leu Ala His Pro Gly Ala 
785                 790                 795                 800 


Trp Val Pro Gly Pro Pro Pro Tyr Leu Pro Arg Gln Gln Ser Asp Gly 
                805                 810                 815     


Ser Leu Leu Arg Ser Gln Arg Pro Met Gly Xaa Ser Arg Arg Gly Leu 
            820                 825                 830         


Arg Gly Pro Ala Gln Val Ser Ala Gln Leu Arg Ala Gly Gly Gly Gly 
        835                 840                 845             


Arg Asp Ala Pro Glu Ala Ala Ala Gln Ser Pro Cys Ser Val Pro Ser 
    850                 855                 860                 


Gln Val Pro Xaa Pro Gly Phe Phe Ser Pro Ala Pro Arg Glu Cys Leu 
865                 870                 875                 880 


Pro Pro Phe Leu Gly Val Pro Lys Pro Gly Leu Tyr Pro Leu Gly Pro 
                885                 890                 895     


Pro Ser Phe Gln Pro Ser Ser Pro Ala Pro Val Trp Arg Ser Ser Leu 
            900                 905                 910         


Gly Pro Pro Ala Pro Leu Asp Arg Gly Glu Asn Leu Tyr Tyr Glu Ile 
        915                 920                 925             


Gly Ala Ser Glu Gly Ser Pro Tyr Ser Gly Pro Xaa Arg Ser Trp Ser 
    930                 935                 940                 


Pro Phe Arg Ser Met Pro Pro Asp Arg Leu Asn Ala Ser Tyr Gly Met 
945                 950                 955                 960 


Leu Gly Gln Ser Pro Pro Leu His Arg Ser Pro Asp Phe Leu Leu Ser 
                965                 970                 975     


Tyr Pro Pro Ala Pro Ser Cys Phe Pro Pro Asp His Leu Gly Tyr Ser 
            980                 985                 990         


Ala Pro Gln His Pro Ala Arg Arg  Pro Xaa Pro Pro Glu  Pro Leu Tyr 
        995                 1000                 1005             


Val Asn  Leu Ala Leu Gly Pro  Arg Gly Pro Ser Pro  Ala Ser Ser 
    1010                 1015                 1020             


Ser Ser  Ser Ser Pro Pro Ala  His Pro Arg Ser Arg  Ser Asp Pro 
    1025                 1030                 1035             


Gly Pro  Pro Val Pro Arg Leu  Pro Gln Lys Gln Arg  Ala Pro Trp 
    1040                 1045                 1050             


Gly Pro  Arg Xaa Pro His Arg  Val Pro Gly Pro Trp  Gly Pro Pro 
    1055                 1060                 1065             


Glu Pro  Leu Leu Leu Tyr Arg  Ala Ala Pro Pro Ala  Tyr Gly Arg 
    1070                 1075                 1080             


Gly Gly  Glu Leu His Arg Gly  Ser Leu Tyr Arg Asn  Gly Gly Gln 
    1085                 1090                 1095             


Arg Gly  Glu Gly Ala Gly Pro  Pro Pro Pro Tyr Pro  Xaa Pro Ser 
    1100                 1105                 1110             


Trp Ser  Leu His Ser Glu Gly  Gln Xaa Arg Ser Tyr  Cys 
    1115                 1120                 1125     


<210> 2842
<211> 863
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<400> 2842
Xaa His Asp Val Ile Gln Gln Leu Pro Pro Pro His Tyr Arg Xaa Leu 
1               5                   10                  15      


Glu Tyr Leu Leu Arg His Leu Ala Arg Met Ala Arg His Ser Ala Asn 
            20                  25                  30          


Xaa Ser Met His Ala Arg Asn Leu Ala Ile Val Trp Ala Pro Asn Leu 
        35                  40                  45              


Leu Arg Ser Met Glu Leu Glu Ser Val Gly Met Gly Gly Ala Ala Ala 
    50                  55                  60                  


Phe Arg Glu Val Arg Val Gln Ser Val Val Val Glu Phe Leu Leu Xaa 
65                  70                  75                  80  


His Val Asp Val Leu Phe Ser Asp Xaa Phe Xaa Ser Ala Gly Leu Asp 
                85                  90                  95      


Pro Ala Gly Arg Cys Leu Leu Pro Arg Pro Lys Ser Leu Ala Gly Ser 
            100                 105                 110         


Cys Pro Ser Xaa Arg Leu Leu Xaa Leu Glu Glu Ala Gln Ala Arg Xaa 
        115                 120                 125             


Gln Gly Arg Leu Gly Xaa Pro Xaa Glu Pro Xaa Xaa Pro Lys Ala Pro 
    130                 135                 140                 


Ala Ser Pro Ala Glu Arg Arg Lys Gly Glu Arg Gly Glu Lys Gln Arg 
145                 150                 155                 160 


Lys Pro Gly Gly Ser Ser Trp Lys Xaa Phe Phe Ala Leu Gly Arg Gly 
                165                 170                 175     


Pro Ser Val Pro Arg Lys Lys Pro Leu Pro Trp Leu Gly Gly Xaa Arg 
            180                 185                 190         


Ala Pro Pro Gln Pro Ser Gly Ser Arg Pro Asp Xaa Val Xaa Leu Arg 
        195                 200                 205             


Ser Ala Lys Ser Glu Glu Ser Leu Ser Ser Gln Ala Ser Gly Ala Gly 
    210                 215                 220                 


Leu Gln Arg Leu His Arg Leu Arg Arg Pro His Ser Ser Ser Asp Ala 
225                 230                 235                 240 


Phe Pro Val Gly Pro Ala Pro Ala Gly Ser Cys Glu Ser Leu Ser Ser 
                245                 250                 255     


Ser Ser Ser Ser Glu Ser Ser Ser Ser Glu Ser Ser Ser Ser Ser Ser 
            260                 265                 270         


Glu Ser Ser Ala Ala Gly Leu Gly Ala Leu Ser Gly Ser Pro Ser His 
        275                 280                 285             


Arg Xaa Ser Ala Trp Leu Asp Asp Gly Asp Glu Leu Asp Phe Ser Pro 
    290                 295                 300                 


Pro Arg Cys Leu Glu Gly Leu Arg Gly Leu Asp Phe Asp Pro Leu Xaa 
305                 310                 315                 320 


Phe Arg Cys Ser Ser Pro Xaa Pro Gly Asp Pro Ala Pro Pro Ala Ser 
                325                 330                 335     


Pro Ala Pro Pro Ala Pro Ala Ser Ala Phe Pro Pro Arg Val Xaa Pro 
            340                 345                 350         


Gln Ala Ile Ser Pro Arg Gly Pro Xaa Ser Pro Ala Ser Pro Ala Ala 
        355                 360                 365             


Leu Asp Ile Ser Glu Pro Leu Ala Val Ser Val Pro Pro Ala Val Leu 
    370                 375                 380                 


Glu Leu Leu Gly Ala Gly Gly Ala Pro Ala Ser Ala Xaa Pro Xaa Pro 
385                 390                 395                 400 


Ala Leu Ser Pro Gly Arg Ser Leu Arg Pro His Leu Ile Pro Leu Leu 
                405                 410                 415     


Leu Arg Gly Ala Glu Ala Pro Leu Xaa Asp Ala Cys Gln Gln Glu Met 
            420                 425                 430         


Cys Ser Lys Leu Arg Gly Ala Gln Gly Pro Leu Gly Pro Asp Met Glu 
        435                 440                 445             


Ser Pro Leu Pro Pro Pro Pro Leu Ser Leu Leu Arg Pro Gly Gly Ala 
    450                 455                 460                 


Pro Pro Pro Pro Pro Lys Asn Pro Ala Arg Leu Met Ala Leu Ala Leu 
465                 470                 475                 480 


Ala Glu Arg Ala Gln Gln Val Ala Glu Gln Gln Ser Gln Gln Glu Cys 
                485                 490                 495     


Gly Gly Xaa Pro Pro Ala Ser Gln Ser Pro Phe His Arg Ser Leu Ser 
            500                 505                 510         


Leu Glu Val Gly Gly Glu Pro Leu Gly Xaa Ser Gly Ser Gly Pro Pro 
        515                 520                 525             


Pro Asn Ser Leu Ala His Pro Gly Ala Trp Val Pro Gly Pro Pro Pro 
    530                 535                 540                 


Tyr Leu Pro Arg Gln Gln Ser Asp Gly Ser Leu Leu Arg Ser Gln Arg 
545                 550                 555                 560 


Pro Met Gly Xaa Ser Arg Arg Gly Leu Arg Gly Pro Ala Gln Val Ser 
                565                 570                 575     


Ala Gln Leu Arg Ala Gly Gly Gly Gly Arg Asp Ala Pro Glu Ala Ala 
            580                 585                 590         


Ala Gln Ser Pro Cys Ser Val Pro Ser Gln Val Pro Xaa Pro Gly Phe 
        595                 600                 605             


Phe Ser Pro Ala Pro Arg Glu Cys Leu Pro Pro Phe Leu Gly Val Pro 
    610                 615                 620                 


Lys Pro Gly Leu Tyr Pro Leu Gly Pro Pro Ser Phe Gln Pro Ser Ser 
625                 630                 635                 640 


Pro Ala Pro Val Trp Arg Ser Ser Leu Gly Pro Pro Ala Pro Leu Asp 
                645                 650                 655     


Arg Gly Glu Asn Leu Tyr Tyr Glu Ile Gly Ala Ser Glu Gly Ser Pro 
            660                 665                 670         


Tyr Ser Gly Pro Xaa Arg Ser Trp Ser Pro Phe Arg Ser Met Pro Pro 
        675                 680                 685             


Asp Arg Leu Asn Ala Ser Tyr Gly Met Leu Gly Gln Ser Pro Pro Leu 
    690                 695                 700                 


His Arg Ser Pro Asp Phe Leu Leu Ser Tyr Pro Pro Ala Pro Ser Cys 
705                 710                 715                 720 


Phe Pro Pro Asp His Leu Gly Tyr Ser Ala Pro Gln His Pro Ala Arg 
                725                 730                 735     


Arg Pro Xaa Pro Pro Glu Pro Leu Tyr Val Asn Leu Ala Leu Gly Pro 
            740                 745                 750         


Arg Gly Pro Ser Pro Ala Ser Ser Ser Ser Ser Ser Pro Pro Ala His 
        755                 760                 765             


Pro Arg Ser Arg Ser Asp Pro Gly Pro Pro Val Pro Arg Leu Pro Gln 
    770                 775                 780                 


Lys Gln Arg Ala Pro Trp Gly Pro Arg Xaa Pro His Arg Val Pro Gly 
785                 790                 795                 800 


Pro Trp Gly Pro Pro Glu Pro Leu Leu Leu Tyr Arg Ala Ala Pro Pro 
                805                 810                 815     


Ala Tyr Gly Arg Gly Gly Glu Leu His Arg Gly Ser Leu Tyr Arg Asn 
            820                 825                 830         


Gly Gly Gln Arg Gly Glu Gly Ala Gly Pro Pro Pro Pro Tyr Pro Xaa 
        835                 840                 845             


Pro Ser Trp Ser Leu His Ser Glu Gly Gln Xaa Arg Ser Tyr Cys 
    850                 855                 860             


<210> 2843
<211> 662
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<400> 2843
Xaa His Glu Phe Asp Ser Glu Arg Ile Pro Glu Leu Ser Gly Pro Ala 
1               5                   10                  15      


Phe Leu Gln Asp Ile His Ser Val Ser Ser Leu Cys Lys Leu Tyr Phe 
            20                  25                  30          


Arg Glu Leu Pro Asn Pro Leu Leu Xaa Tyr Gln Leu Tyr Gly Lys Phe 
        35                  40                  45              


Ser Glu Ala Met Ser Val Pro Gly Glu Glu Glu Arg Leu Val Arg Val 
    50                  55                  60                  


His Asp Val Ile Gln Gln Leu Pro Pro Pro His Tyr Arg Xaa Leu Glu 
65                  70                  75                  80  


Tyr Leu Leu Arg His Leu Ala Arg Met Ala Arg His Ser Ala Asn Xaa 
                85                  90                  95      


Ser Met His Ala Arg Asn Leu Ala Ile Val Trp Ala Pro Asn Leu Leu 
            100                 105                 110         


Arg Ser Met Glu Leu Glu Ser Val Gly Met Gly Gly Ala Ala Ala Phe 
        115                 120                 125             


Arg Glu Val Arg Val Gln Ser Val Val Val Glu Phe Leu Leu Xaa His 
    130                 135                 140                 


Val Asp Val Leu Phe Ser Asp Xaa Phe Xaa Ser Ala Gly Leu Asp Pro 
145                 150                 155                 160 


Ala Gly Arg Cys Leu Leu Pro Arg Pro Lys Ser Leu Ala Gly Ser Cys 
                165                 170                 175     


Pro Ser Xaa Arg Leu Leu Xaa Leu Glu Glu Ala Gln Ala Arg Xaa Gln 
            180                 185                 190         


Gly Arg Leu Gly Xaa Pro Xaa Glu Pro Xaa Xaa Pro Lys Ala Pro Ala 
        195                 200                 205             


Ser Pro Ala Glu Arg Arg Lys Gly Glu Arg Gly Glu Lys Gln Arg Lys 
    210                 215                 220                 


Pro Gly Gly Ser Ser Trp Lys Xaa Phe Phe Ala Leu Gly Arg Gly Pro 
225                 230                 235                 240 


Ser Val Pro Arg Lys Lys Pro Leu Pro Trp Leu Gly Gly Xaa Arg Ala 
                245                 250                 255     


Pro Pro Gln Pro Ser Gly Ser Arg Pro Asp Xaa Val Xaa Leu Arg Ser 
            260                 265                 270         


Ala Lys Ser Glu Glu Ser Leu Ser Ser Gln Ala Ser Gly Ala Gly Leu 
        275                 280                 285             


Gln Arg Leu His Arg Leu Arg Arg Pro His Ser Ser Ser Asp Ala Phe 
    290                 295                 300                 


Pro Val Gly Pro Ala Pro Ala Gly Ser Cys Glu Ser Leu Ser Ser Ser 
305                 310                 315                 320 


Ser Ser Ser Glu Ser Ser Ser Ser Glu Ser Ser Ser Ser Ser Ser Glu 
                325                 330                 335     


Ser Ser Ala Ala Gly Leu Gly Ala Leu Ser Gly Ser Pro Ser His Arg 
            340                 345                 350         


Xaa Ser Ala Trp Leu Asp Asp Gly Asp Glu Leu Asp Phe Ser Pro Pro 
        355                 360                 365             


Arg Cys Leu Glu Gly Leu Arg Gly Leu Asp Phe Asp Pro Leu Xaa Phe 
    370                 375                 380                 


Arg Cys Ser Ser Pro Xaa Pro Gly Asp Pro Ala Pro Pro Ala Ser Pro 
385                 390                 395                 400 


Ala Pro Pro Ala Pro Ala Ser Ala Phe Pro Pro Arg Val Xaa Pro Gln 
                405                 410                 415     


Ala Ile Ser Pro Arg Gly Pro Xaa Ser Pro Ala Ser Pro Ala Ala Leu 
            420                 425                 430         


Asp Ile Ser Glu Pro Leu Ala Val Ser Val Pro Pro Ala Val Leu Glu 
        435                 440                 445             


Leu Leu Gly Ala Gly Gly Ala Pro Ala Ser Ala Xaa Pro Xaa Pro Ala 
    450                 455                 460                 


Leu Ser Pro Gly Arg Ser Leu Arg Pro His Leu Ile Pro Leu Leu Leu 
465                 470                 475                 480 


Arg Gly Ala Glu Ala Pro Leu Xaa Asp Ala Cys Gln Gln Glu Met Cys 
                485                 490                 495     


Ser Lys Leu Arg Gly Ala Gln Gly Pro Leu Gly Pro Asp Met Glu Ser 
            500                 505                 510         


Pro Leu Pro Pro Pro Pro Leu Ser Leu Leu Arg Pro Gly Gly Ala Pro 
        515                 520                 525             


Pro Pro Pro Pro Lys Asn Pro Ala Arg Leu Met Ala Leu Ala Leu Ala 
    530                 535                 540                 


Glu Arg Ala Gln Gln Val Ala Glu Gln Gln Ser Gln Gln Glu Cys Gly 
545                 550                 555                 560 


Gly Xaa Pro Pro Ala Ser Gln Ser Pro Phe His Arg Ser Leu Ser Leu 
                565                 570                 575     


Glu Val Gly Gly Glu Pro Leu Gly Xaa Ser Gly Ser Gly Pro Pro Pro 
            580                 585                 590         


Asn Ser Leu Ala His Pro Gly Ala Trp Val Pro Gly Pro Pro Pro Tyr 
        595                 600                 605             


Leu Pro Arg Gln Gln Ser Asp Gly Ser Leu Leu Arg Ser Gln Arg Pro 
    610                 615                 620                 


Met Gly Xaa Ser Arg Arg Gly Leu Arg Gly Pro Ala Gln Glu Pro Pro 
625                 630                 635                 640 


Ala Cys Pro Asp Leu Cys Xaa Gly Met Gly Gly Gln Leu Leu Pro Phe 
                645                 650                 655     


Phe Pro His Met Pro His 
            660         


<210> 2844
<211> 749
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<400> 2844
Met Met Met Ala Arg Lys Gln Asp Val Arg Ile Pro Xaa Tyr Asn Ile 
1               5                   10                  15      


Ser Val Val Gly Leu Ser Gly Xaa Glu Lys Glu Lys Gly Gln Cys Gly 
            20                  25                  30          


Ile Gly Lys Ser Cys Leu Cys Asn Arg Phe Val Arg Pro Ser Ala Asp 
        35                  40                  45              


Glu Phe His Leu Asp His Xaa Ser Val Leu Ser Xaa Ser Asp Phe Gly 
    50                  55                  60                  


Gly Arg Val Val Asn Asn Asp His Phe Leu Tyr Trp Gly Glu Val Ser 
65                  70                  75                  80  


Arg Ser Leu Glu Asp Cys Val Glu Cys Lys Met His Ile Val Glu Gln 
                85                  90                  95      


Xaa Glu Phe Ile Asp Asp Gln Xaa Phe Gln Pro His Arg Ser Xaa Ala 
            100                 105                 110         


Leu Gln Pro Tyr Ile Lys Arg Ala Ala Ala Xaa Lys Leu Ala Ser Ala 
        115                 120                 125             


Glu Lys Leu Met Tyr Phe Cys Xaa Asp Gln Leu Gly Leu Glu Gln Asp 
    130                 135                 140                 


Phe Glu Gln Lys Gln Met Pro Asp Gly Lys Leu Leu Val Asp Gly Phe 
145                 150                 155                 160 


Leu Leu Gly Ile Asp Val Ser Arg Gly Met Asn Arg Asn Phe Asp Asp 
                165                 170                 175     


Gln Leu Lys Phe Val Ser Asn Leu Tyr Asn Gln Leu Ala Lys Xaa Lys 
            180                 185                 190         


Lys Pro Ile Val Val Val Leu Xaa Lys Cys Asp Glu Gly Val Glu Arg 
        195                 200                 205             


Tyr Ile Arg Asp Ala His Xaa Phe Ala Leu Ser Lys Lys Asn Leu Gln 
    210                 215                 220                 


Val Val Glu Xaa Ser Ala Arg Ser Asn Val Asn Val Asp Leu Ala Phe 
225                 230                 235                 240 


Ser Xaa Leu Val Gln Leu Ile Asp Lys Ser Arg Gly Lys Xaa Lys Ile 
                245                 250                 255     


Ile Pro Tyr Phe Glu Ala Leu Lys Gln Gln Ser Gln Gln Ile Ala Xaa 
            260                 265                 270         


Ala Lys Asp Lys Tyr Glu Trp Leu Val Ser Arg Ile Val Lys Asn His 
        275                 280                 285             


Asn Glu Asn Trp Leu Ser Val Ser Arg Lys Met Gln Ala Ser Pro Glu 
    290                 295                 300                 


Tyr Gln Asp Tyr Val Tyr Leu Glu Gly Xaa Gln Lys Ala Lys Lys Leu 
305                 310                 315                 320 


Phe Leu Gln His Ile His Arg Leu Lys His Glu His Ile Glu Arg Arg 
                325                 330                 335     


Arg Lys Leu Tyr Leu Ala Ala Leu Pro Leu Ala Phe Glu Ala Leu Ile 
            340                 345                 350         


Pro Asn Leu Asp Glu Ile Asp His Leu Ser Cys Ile Lys Ala Lys Lys 
        355                 360                 365             


Leu Leu Glu Xaa Lys Pro Glu Phe Leu Lys Trp Phe Val Val Leu Glu 
    370                 375                 380                 


Glu Xaa Pro Trp Asp Ala Xaa Ser His Ile Asp Asn Met Glu Asn Glu 
385                 390                 395                 400 


Arg Ile Pro Phe Asp Leu Met Asp Xaa Val Pro Ala Glu Gln Leu Tyr 
                405                 410                 415     


Glu Ala His Leu Glu Lys Leu Arg Asn Glu Arg Lys Arg Val Glu Met 
            420                 425                 430         


Arg Arg Ala Phe Lys Glu Asn Leu Glu Xaa Ser Pro Phe Ile Xaa Pro 
        435                 440                 445             


Gly Lys Pro Trp Glu Glu Ala Arg Ser Phe Ile Met Asn Glu Asp Phe 
    450                 455                 460                 


Tyr Gln Trp Leu Glu Glu Ser Val Tyr Met Asp Ile Tyr Gly Lys His 
465                 470                 475                 480 


Gln Lys Gln Ile Ile Asp Lys Ala Lys Glu Glu Phe Gln Glu Leu Leu 
                485                 490                 495     


Leu Glu Tyr Ser Glu Leu Phe Tyr Glu Leu Glu Leu Asp Ala Lys Pro 
            500                 505                 510         


Ser Lys Glu Lys Met Gly Val Ile Gln Asp Val Leu Gly Glu Glu Gln 
        515                 520                 525             


Arg Phe Lys Ala Leu Gln Lys Leu Gln Ala Glu Arg Asp Ala Leu Ile 
    530                 535                 540                 


Leu Lys His Ile His Phe Val Tyr His Pro Xaa Lys Glu Xaa Cys Pro 
545                 550                 555                 560 


Ser Cys Pro Ala Cys Val Asp Ala Lys Ile Glu His Leu Ile Ser Ser 
                565                 570                 575     


Arg Phe Ile Arg Pro Ser Asp Arg Asn Gln Lys Asn Ser Leu Ser Asp 
            580                 585                 590         


Pro Asn Ile Asp Arg Ile Asn Leu Val Ile Leu Gly Lys Asp Gly Leu 
        595                 600                 605             


Ala Arg Glu Leu Ala Asn Glu Ile Arg Ala Leu Cys Xaa Asn Asp Asp 
    610                 615                 620                 


Lys Tyr Val Ile Asp Gly Lys Met Tyr Glu Leu Ser Leu Arg Pro Ile 
625                 630                 635                 640 


Glu Gly Asn Val Arg Leu Pro Val Asn Ser Phe Gln Xaa Pro Xaa Phe 
                645                 650                 655     


Gln Pro His Gly Cys Leu Cys Leu Tyr Asn Ser Lys Glu Ser Leu Ser 
            660                 665                 670         


Tyr Val Val Glu Ser Ile Glu Lys Ser Arg Glu Ser Xaa Leu Gly Arg 
        675                 680                 685             


Arg Asp Asn His Leu Val His Leu Pro Leu Xaa Leu Ile Leu Val Asn 
    690                 695                 700                 


Lys Arg Gly Asp Xaa Ser Gly Glu Xaa Leu His Ser Leu Ile Gln Gln 
705                 710                 715                 720 


Gly Gln Gln Ile Ala Ser Lys Leu Gln Cys Val Phe Leu Asp Pro Ala 
                725                 730                 735     


Ser Ala Gly Ala Ala Asp Leu Ser Trp Leu Gly Pro Ile 
            740                 745                 


<210> 2845
<211> 1499
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1173)..(1173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1226)..(1226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1238)..(1238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1252)..(1253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1313)..(1313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1316)..(1316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1392)..(1392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1403)..(1403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1411)..(1411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1416)..(1416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1418)..(1418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1442)..(1442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1463)..(1463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1465)..(1465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1480)..(1480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1498)..(1498)
<223> Selenocysteine

<400> 2845
Met Met Met Ala Arg Lys Gln Asp Val Arg Ile Pro Xaa Tyr Asn Ile 
1               5                   10                  15      


Ser Val Val Gly Leu Ser Gly Xaa Glu Lys Glu Lys Gly Gln Cys Gly 
            20                  25                  30          


Ile Gly Lys Ser Cys Leu Cys Asn Arg Phe Val Arg Pro Ser Ala Asp 
        35                  40                  45              


Glu Phe His Leu Asp His Xaa Ser Val Leu Ser Xaa Ser Asp Phe Gly 
    50                  55                  60                  


Gly Arg Val Val Asn Asn Asp His Phe Leu Tyr Trp Gly Glu Val Ser 
65                  70                  75                  80  


Arg Ser Leu Glu Asp Cys Val Glu Cys Lys Met His Ile Val Glu Gln 
                85                  90                  95      


Xaa Glu Phe Ile Asp Asp Gln Xaa Phe Gln Pro His Arg Ser Xaa Ala 
            100                 105                 110         


Leu Gln Pro Tyr Ile Lys Arg Ala Ala Ala Xaa Lys Leu Ala Ser Ala 
        115                 120                 125             


Glu Lys Leu Met Tyr Phe Cys Xaa Asp Gln Leu Gly Leu Glu Gln Asp 
    130                 135                 140                 


Phe Glu Gln Lys Gln Met Pro Asp Gly Lys Leu Leu Val Asp Gly Phe 
145                 150                 155                 160 


Leu Leu Gly Ile Asp Val Ser Arg Gly Met Asn Arg Asn Phe Asp Asp 
                165                 170                 175     


Gln Leu Lys Phe Val Ser Asn Leu Tyr Asn Gln Leu Ala Lys Xaa Lys 
            180                 185                 190         


Lys Pro Ile Val Val Val Leu Xaa Lys Cys Asp Glu Gly Val Glu Arg 
        195                 200                 205             


Tyr Ile Arg Asp Ala His Xaa Phe Ala Leu Ser Lys Lys Asn Leu Gln 
    210                 215                 220                 


Val Val Glu Xaa Ser Ala Arg Ser Asn Val Asn Val Asp Leu Ala Phe 
225                 230                 235                 240 


Ser Xaa Leu Val Gln Leu Ile Asp Lys Ser Arg Gly Lys Xaa Lys Ile 
                245                 250                 255     


Ile Pro Tyr Phe Glu Ala Leu Lys Gln Gln Ser Gln Gln Ile Ala Xaa 
            260                 265                 270         


Ala Lys Asp Lys Tyr Glu Trp Leu Val Ser Arg Ile Val Lys Asn His 
        275                 280                 285             


Asn Glu Asn Trp Leu Ser Val Ser Arg Lys Met Gln Ala Ser Pro Glu 
    290                 295                 300                 


Tyr Gln Asp Tyr Val Tyr Leu Glu Gly Xaa Gln Lys Ala Lys Lys Leu 
305                 310                 315                 320 


Phe Leu Gln His Ile His Arg Leu Lys His Glu His Ile Glu Arg Arg 
                325                 330                 335     


Arg Lys Leu Tyr Leu Ala Ala Leu Pro Leu Ala Phe Glu Ala Leu Ile 
            340                 345                 350         


Pro Asn Leu Asp Glu Ile Asp His Leu Ser Cys Ile Lys Ala Lys Lys 
        355                 360                 365             


Leu Leu Glu Xaa Lys Pro Glu Phe Leu Lys Trp Phe Val Val Leu Glu 
    370                 375                 380                 


Glu Xaa Pro Trp Asp Ala Xaa Ser His Ile Asp Asn Met Glu Asn Glu 
385                 390                 395                 400 


Arg Ile Pro Phe Asp Leu Met Asp Xaa Val Pro Ala Glu Gln Leu Tyr 
                405                 410                 415     


Glu Ala His Leu Glu Lys Leu Arg Asn Glu Arg Lys Arg Val Glu Met 
            420                 425                 430         


Arg Arg Ala Phe Lys Glu Asn Leu Glu Xaa Ser Pro Phe Ile Xaa Pro 
        435                 440                 445             


Gly Lys Pro Trp Glu Glu Ala Arg Ser Phe Ile Met Asn Glu Asp Phe 
    450                 455                 460                 


Tyr Gln Trp Leu Glu Glu Ser Val Tyr Met Asp Ile Tyr Gly Lys His 
465                 470                 475                 480 


Gln Lys Gln Ile Ile Asp Lys Ala Lys Glu Glu Phe Gln Glu Leu Leu 
                485                 490                 495     


Leu Glu Tyr Ser Glu Leu Phe Tyr Glu Leu Glu Leu Asp Ala Lys Pro 
            500                 505                 510         


Ser Lys Glu Lys Met Gly Val Ile Gln Asp Val Leu Gly Glu Glu Gln 
        515                 520                 525             


Arg Phe Lys Ala Leu Gln Lys Leu Gln Ala Glu Arg Asp Ala Leu Ile 
    530                 535                 540                 


Leu Lys His Ile His Phe Val Tyr His Pro Xaa Lys Glu Xaa Cys Pro 
545                 550                 555                 560 


Ser Cys Pro Ala Cys Val Asp Ala Lys Ile Glu His Leu Ile Ser Ser 
                565                 570                 575     


Arg Phe Ile Arg Pro Ser Asp Arg Asn Gln Lys Asn Ser Leu Ser Asp 
            580                 585                 590         


Pro Asn Ile Asp Arg Ile Asn Leu Val Ile Leu Gly Lys Asp Gly Leu 
        595                 600                 605             


Ala Arg Glu Leu Ala Asn Glu Ile Arg Ala Leu Cys Xaa Asn Asp Asp 
    610                 615                 620                 


Lys Tyr Val Ile Asp Gly Lys Met Tyr Glu Leu Ser Leu Arg Pro Ile 
625                 630                 635                 640 


Glu Gly Asn Val Arg Leu Pro Val Asn Ser Phe Gln Xaa Pro Xaa Phe 
                645                 650                 655     


Gln Pro His Gly Cys Leu Cys Leu Tyr Asn Ser Lys Glu Ser Leu Ser 
            660                 665                 670         


Tyr Val Val Glu Ser Ile Glu Lys Ser Arg Glu Ser Xaa Leu Gly Arg 
        675                 680                 685             


Arg Asp Asn His Leu Val His Leu Pro Leu Xaa Leu Ile Leu Val Asn 
    690                 695                 700                 


Lys Arg Gly Asp Xaa Ser Gly Glu Xaa Leu His Ser Leu Ile Gln Gln 
705                 710                 715                 720 


Gly Gln Gln Ile Ala Ser Lys Leu Gln Cys Val Phe Leu Asp Pro Ala 
                725                 730                 735     


Ser Ala Gly Ile Gly Tyr Gly Arg Asn Ile Asn Glu Lys Gln Ile Ser 
            740                 745                 750         


Gln Val Leu Lys Gly Leu Leu Asp Ser Lys Arg Asn Leu Asn Leu Val 
        755                 760                 765             


Ser Ser Xaa Ala Ser Ile Lys Asp Leu Ala Asp Val Asp Leu Arg Ile 
    770                 775                 780                 


Val Met Cys Leu Met Cys Gly Asp Pro Phe Ser Ala Asp Asp Ile Leu 
785                 790                 795                 800 


Phe Pro Val Leu Gln Ser Gln Xaa Cys Lys Ser Ser His Cys Gly Ser 
                805                 810                 815     


Asn Asn Ser Val Leu Leu Glu Leu Pro Ile Gly Leu His Lys Lys Arg 
            820                 825                 830         


Ile Glu Leu Ser Val Leu Ser Tyr His Ser Ser Phe Ser Ile Arg Lys 
        835                 840                 845             


Ser Arg Leu Val His Gly Tyr Ile Val Phe Tyr Ser Ala Lys Arg Lys 
    850                 855                 860                 


Ala Ser Leu Ala Met Leu Arg Ala Phe Leu Cys Glu Val Gln Asp Ile 
865                 870                 875                 880 


Ile Pro Ile Gln Leu Val Ala Leu Xaa Asp Gly Ala Val Asp Val Leu 
                885                 890                 895     


Asp Asn Asp Leu Ser Arg Glu Gln Leu Xaa Glu Gly Glu Glu Ile Ala 
            900                 905                 910         


Gln Glu Ile Asp Gly Arg Phe Xaa Ser Ile Pro Cys Ser Gln Pro Gln 
        915                 920                 925             


His Lys Leu Glu Ile Phe His Pro Phe Phe Lys Asp Val Val Glu Lys 
    930                 935                 940                 


Lys Asn Ile Ile Glu Ala Xaa His Met Tyr Asp Asn Ala Ala Glu Ala 
945                 950                 955                 960 


Cys Ser Xaa Xaa Glu Glu Val Phe Asn Ser Pro Arg Ala Gly Ser Pro 
                965                 970                 975     


Leu Cys Asn Ser Asn Leu Gln Asp Ser Glu Glu Asp Ile Glu Pro Ser 
            980                 985                 990         


Tyr Ser Leu Phe Arg Glu Asp Xaa  Ser Leu Pro Ser Leu  Ser Lys Asp 
        995                 1000                 1005             


His Ser  Lys Leu Ser Met Glu  Leu Glu Gly Asn Asp  Gly Leu Ser 
    1010                 1015                 1020             


Phe Ile  Met Ser Asn Phe Glu  Ser Lys Leu Asn Asn  Lys Val Pro 
    1025                 1030                 1035             


Pro Pro  Val Lys Pro Lys Pro  Pro Val His Phe Glu  Ile Xaa Lys 
    1040                 1045                 1050             


Gly Asp  Leu Ser Tyr Leu Asp  Gln Gly His Arg Asp  Gly Gln Arg 
    1055                 1060                 1065             


Lys Ser  Val Ser Ser Ser Pro  Trp Leu Pro Gln Asp  Gly Phe Asp 
    1070                 1075                 1080             


Pro Ser  Asp Tyr Ala Glu Pro  Met Asp Ala Val Val  Lys Pro Arg 
    1085                 1090                 1095             


Asn Glu  Glu Glu Asn Ile Tyr  Ser Val Pro His Asp  Ser Xaa Gln 
    1100                 1105                 1110             


Gly Lys  Ile Ile Xaa Ile Arg  Asn Ile Asn Lys Ala  Gln Ser Asn 
    1115                 1120                 1125             


Gly Ser  Gly Asn Gly Ser Asp  Ser Glu Met Asp Xaa  Ser Ser Leu 
    1130                 1135                 1140             


Glu Arg  Gly Arg Lys Val Ser  Ile Val Ser Lys Pro  Val Leu Tyr 
    1145                 1150                 1155             


Arg Xaa  Arg Cys Xaa Arg Leu  Gly Arg Phe Ala Ser  Tyr Arg Xaa 
    1160                 1165                 1170             


Ser Phe  Ser Val Gly Ser Asp  Asp Glu Leu Gly Pro  Ile Arg Lys 
    1175                 1180                 1185             


Lys Glu  Glu Asp Gln Ala Ser  Gln Gly Tyr Lys Gly  Asp Asn Ala 
    1190                 1195                 1200             


Val Ile  Pro Tyr Glu Xaa Asp  Glu Asp Pro Arg Arg  Arg Asn Ile 
    1205                 1210                 1215             


Leu Arg  Ser Leu Arg Arg Asn  Xaa Lys Lys Pro Lys  Pro Lys Pro 
    1220                 1225                 1230             


Arg Pro  Ser Ile Xaa Lys Ala  Xaa Trp Glu Ser Asn  Tyr Phe Gly 
    1235                 1240                 1245             


Val Pro  Leu Xaa Xaa Val Val  Xaa Pro Glu Lys Pro  Ile Pro Ile 
    1250                 1255                 1260             


Phe Ile  Glu Arg Cys Ile Glu  Tyr Ile Glu Ala Xaa  Gly Leu Ser 
    1265                 1270                 1275             


Xaa Glu  Gly Ile Tyr Arg Val  Ser Gly Asn Lys Ser  Glu Met Glu 
    1280                 1285                 1290             


Ser Leu  Gln Arg Gln Phe Asp  Gln Asp His Asn Leu  Asp Leu Ala 
    1295                 1300                 1305             


Glu Lys  Asp Phe Xaa Val Asn  Xaa Val Ala Gly Ala  Met Lys Ser 
    1310                 1315                 1320             


Phe Phe  Ser Glu Leu Pro Asp  Pro Leu Val Pro Tyr  Asn Met Gln 
    1325                 1330                 1335             


Ile Asp  Leu Val Glu Ala His  Lys Ile Asn Asp Arg  Glu Gln Lys 
    1340                 1345                 1350             


Leu His  Ala Leu Lys Glu Val  Leu Lys Lys Phe Pro  Lys Glu Asn 
    1355                 1360                 1365             


His Glu  Val Phe Lys Tyr Val  Ile Ser His Leu Asn  Lys Val Ser 
    1370                 1375                 1380             


His Asn  Asn Lys Val Asn Leu  Met Xaa Ser Glu Asn  Leu Ser Ile 
    1385                 1390                 1395             


Cys Phe  Trp Pro Xaa Leu Met  Arg Pro Asp Phe Ser  Xaa Met Asp 
    1400                 1405                 1410             


Ala Leu  Xaa Ala Xaa Arg Xaa  Tyr Gln Xaa Ile Ile  Glu Leu Phe 
    1415                 1420                 1425             


Ile Gln  Gln Cys Pro Phe Phe  Phe Tyr Asn Arg Pro  Ile Xaa Glu 
    1430                 1435                 1440             


Pro Pro  Gly Ala Arg Pro Ser  Ser Pro Ser Ala Val  Ala Ser Xaa 
    1445                 1450                 1455             


Val Pro  Phe Leu Xaa Ser Xaa  Pro Val Xaa Ser Gln  Pro Ser Pro 
    1460                 1465                 1470             


Pro Gln  Ser Pro Pro Pro Xaa  Pro Gln Ser Pro Met  Gln Pro Leu 
    1475                 1480                 1485             


Leu Pro  Ser Gln Leu Gln Ala  Glu His Xaa Leu 
    1490                 1495                 


<210> 2846
<211> 535
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<400> 2846
Met Ala Trp Ile Leu Asp Cys Leu Phe Ala Ser Ala Phe Glu Pro Arg 
1               5                   10                  15      


Pro Arg Arg Val Ser Val Leu Gly Gly Ala Pro Gly His Asn Pro Asp 
            20                  25                  30          


Arg Arg Xaa Lys Met Val Ser Ile His Ser Leu Ser Glu Leu Glu Arg 
        35                  40                  45              


Leu Lys Leu Gln Glu Xaa Ala Tyr His Glu Leu Val Ala Arg His Phe 
    50                  55                  60                  


Leu Ser Glu Phe Lys Pro Asp Arg Ala Leu Pro Ile Asp Arg Pro Asn 
65                  70                  75                  80  


Xaa Leu Asp Lys Trp Phe Leu Ile Leu Arg Gly Gln Gln Arg Ala Val 
                85                  90                  95      


Ser His Lys Xaa Phe Gly Ile Ser Leu Glu Glu Val Leu Val Asn Glu 
            100                 105                 110         


Phe Xaa Arg Arg Lys His Leu Glu Leu Xaa Ala Xaa Met Gln Val Glu 
        115                 120                 125             


Glu Ala Xaa Gly Gln Ala Ala Gly Arg Arg Arg Gly Asn Val Val Arg 
    130                 135                 140                 


Arg Val Phe Gly Arg Ile Arg Arg Phe Phe Ser Arg Arg Arg Asn Glu 
145                 150                 155                 160 


Pro Xaa Leu Pro Arg Glu Phe Xaa Arg Arg Gly Arg Arg Gly Ala Val 
                165                 170                 175     


Ser Val Asp Ser Leu Ala Glu Leu Glu Asp Gly Ala Leu Leu Leu Gln 
            180                 185                 190         


Xaa Leu Gln Leu Ser Lys Ile Ser Phe Pro Ile Gly Gln Arg Leu Leu 
        195                 200                 205             


Gly Ser Lys Arg Lys Met Ser Leu Asn Pro Ile Ala Lys Gln Ile Pro 
    210                 215                 220                 


Gln Val Val Glu Ala Cys Cys Gln Phe Ile Glu Lys His Gly Leu Ser 
225                 230                 235                 240 


Ala Val Gly Ile Phe Xaa Leu Glu Tyr Ser Val Gln Arg Val Arg Gln 
                245                 250                 255     


Leu Arg Glu Glu Phe Asp Gln Gly Leu Asp Val Val Leu Asp Asp Asn 
            260                 265                 270         


Gln Asn Val His Asp Val Ala Ala Leu Leu Lys Glu Phe Phe Arg Asp 
        275                 280                 285             


Met Lys Asp Ser Leu Leu Pro Asp Asp Leu Tyr Met Ser Phe Leu Leu 
    290                 295                 300                 


Xaa Ala Xaa Leu Lys Pro Gln Asp Gln Leu Ser Ala Leu Gln Leu Leu 
305                 310                 315                 320 


Val Tyr Leu Met Pro Pro Cys His Ser Asp Xaa Leu Glu Arg Leu Leu 
                325                 330                 335     


Lys Ala Leu His Lys Ile Xaa Glu Asn Cys Glu Asp Ser Ile Gly Ile 
            340                 345                 350         


Asp Gly Gln Leu Val Pro Gly Asn Arg Met Xaa Ser Xaa Asn Leu Ala 
        355                 360                 365             


Leu Val Phe Gly Ser Ala Leu Leu Lys Lys Gly Lys Phe Gly Lys Arg 
    370                 375                 380                 


Glu Ser Arg Lys Xaa Lys Leu Gly Ile Asp His Tyr Val Ala Ser Val 
385                 390                 395                 400 


Asn Val Val Arg Ala Met Ile Asp Asn Trp Asp Val Leu Phe Gln Val 
                405                 410                 415     


Pro Pro His Ile Gln Arg Gln Val Ala Lys Arg Val Trp Lys Ser Ser 
            420                 425                 430         


Pro Glu Ala Leu Asp Phe Ile Arg Arg Arg Asn Leu Arg Lys Ile Gln 
        435                 440                 445             


Ser Ala Arg Ile Lys Met Glu Glu Asp Ala Leu Leu Ser Asp Pro Val 
    450                 455                 460                 


Glu Xaa Ser Ala Glu Ala Arg Ala Ala Val Leu Ala Gln Ser Lys Pro 
465                 470                 475                 480 


Ser Asp Glu Gly Ser Ser Glu Glu Pro Ala Val Pro Ser Gly Xaa Ala 
                485                 490                 495     


Arg Ser His Asp Asp Glu Glu Gly Ala Gly Asn Pro Pro Ile Pro Glu 
            500                 505                 510         


Gln Asp Arg Pro Leu Leu Arg Val Pro Arg Glu Lys Glu Ala Lys Xaa 
        515                 520                 525             


Gly Val Ser Tyr Phe Phe Pro 
    530                 535 


<210> 2847
<211> 547
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<400> 2847
Met Gly Gly Cys Ile Pro Phe Leu Lys Ala Ala Arg Ala Leu Cys Pro 
1               5                   10                  15      


Arg Ile Met Pro Pro Leu Leu Leu Leu Ser Ala Phe Ile Phe Leu Val 
            20                  25                  30          


Ser Val Leu Gly Gly Ala Pro Gly His Asn Pro Asp Arg Arg Xaa Lys 
        35                  40                  45              


Met Val Ser Ile His Ser Leu Ser Glu Leu Glu Arg Leu Lys Leu Gln 
    50                  55                  60                  


Glu Xaa Ala Tyr His Glu Leu Val Ala Arg His Phe Leu Ser Glu Phe 
65                  70                  75                  80  


Lys Pro Asp Arg Ala Leu Pro Ile Asp Arg Pro Asn Xaa Leu Asp Lys 
                85                  90                  95      


Trp Phe Leu Ile Leu Arg Gly Gln Gln Arg Ala Val Ser His Lys Xaa 
            100                 105                 110         


Phe Gly Ile Ser Leu Glu Glu Val Leu Val Asn Glu Phe Xaa Arg Arg 
        115                 120                 125             


Lys His Leu Glu Leu Xaa Ala Xaa Met Gln Val Glu Glu Ala Xaa Gly 
    130                 135                 140                 


Gln Ala Ala Gly Arg Arg Arg Gly Asn Val Val Arg Arg Val Phe Gly 
145                 150                 155                 160 


Arg Ile Arg Arg Phe Phe Ser Arg Arg Arg Asn Glu Pro Xaa Leu Pro 
                165                 170                 175     


Arg Glu Phe Xaa Arg Arg Gly Arg Arg Gly Ala Val Ser Val Asp Ser 
            180                 185                 190         


Leu Ala Glu Leu Glu Asp Gly Ala Leu Leu Leu Gln Xaa Leu Gln Leu 
        195                 200                 205             


Ser Lys Ile Ser Phe Pro Ile Gly Gln Arg Leu Leu Gly Ser Lys Arg 
    210                 215                 220                 


Lys Met Ser Leu Asn Pro Ile Ala Lys Gln Ile Pro Gln Val Val Glu 
225                 230                 235                 240 


Ala Cys Cys Gln Phe Ile Glu Lys His Gly Leu Ser Ala Val Gly Ile 
                245                 250                 255     


Phe Xaa Leu Glu Tyr Ser Val Gln Arg Val Arg Gln Leu Arg Glu Glu 
            260                 265                 270         


Phe Asp Gln Gly Leu Asp Val Val Leu Asp Asp Asn Gln Asn Val His 
        275                 280                 285             


Asp Val Ala Ala Leu Leu Lys Glu Phe Phe Arg Asp Met Lys Asp Ser 
    290                 295                 300                 


Leu Leu Pro Asp Asp Leu Tyr Met Ser Phe Leu Leu Xaa Ala Xaa Leu 
305                 310                 315                 320 


Lys Pro Gln Asp Gln Leu Ser Ala Leu Gln Leu Leu Val Tyr Leu Met 
                325                 330                 335     


Pro Pro Cys His Ser Asp Xaa Leu Glu Arg Leu Leu Lys Ala Leu His 
            340                 345                 350         


Lys Ile Xaa Glu Asn Cys Glu Asp Ser Ile Gly Ile Asp Gly Gln Leu 
        355                 360                 365             


Val Pro Gly Asn Arg Met Xaa Ser Xaa Asn Leu Ala Leu Val Phe Gly 
    370                 375                 380                 


Ser Ala Leu Leu Lys Lys Gly Lys Phe Gly Lys Arg Glu Ser Arg Lys 
385                 390                 395                 400 


Xaa Lys Leu Gly Ile Asp His Tyr Val Ala Ser Val Asn Val Val Arg 
                405                 410                 415     


Ala Met Ile Asp Asn Trp Asp Val Leu Phe Gln Val Pro Pro His Ile 
            420                 425                 430         


Gln Arg Gln Val Ala Lys Arg Val Trp Lys Ser Ser Pro Glu Ala Leu 
        435                 440                 445             


Asp Phe Ile Arg Arg Arg Asn Leu Arg Lys Ile Gln Ser Ala Arg Ile 
    450                 455                 460                 


Lys Met Glu Glu Asp Ala Leu Leu Ser Asp Pro Val Glu Xaa Ser Ala 
465                 470                 475                 480 


Glu Ala Arg Ala Ala Val Leu Ala Gln Ser Lys Pro Ser Asp Glu Gly 
                485                 490                 495     


Ser Ser Glu Glu Pro Ala Val Pro Ser Gly Xaa Ala Arg Ser His Asp 
            500                 505                 510         


Asp Glu Glu Gly Ala Gly Asn Pro Pro Ile Pro Glu Gln Asp Arg Pro 
        515                 520                 525             


Leu Leu Arg Val Pro Arg Glu Lys Glu Ala Lys Xaa Gly Val Ser Tyr 
    530                 535                 540                 


Phe Phe Pro 
545         


<210> 2848
<211> 411
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<400> 2848
Met Gln Val Glu Glu Ala Xaa Gly Gln Ala Ala Gly Arg Arg Arg Gly 
1               5                   10                  15      


Asn Val Val Arg Arg Val Phe Gly Arg Ile Arg Arg Phe Phe Ser Arg 
            20                  25                  30          


Arg Arg Asn Glu Pro Xaa Leu Pro Arg Glu Phe Xaa Arg Arg Gly Arg 
        35                  40                  45              


Arg Gly Ala Val Ser Val Asp Ser Leu Ala Glu Leu Glu Asp Gly Ala 
    50                  55                  60                  


Leu Leu Leu Gln Xaa Leu Gln Leu Ser Lys Ile Ser Phe Pro Ile Gly 
65                  70                  75                  80  


Gln Arg Leu Leu Gly Ser Lys Arg Lys Met Ser Leu Asn Pro Ile Ala 
                85                  90                  95      


Lys Gln Ile Pro Gln Val Val Glu Ala Cys Cys Gln Phe Ile Glu Lys 
            100                 105                 110         


His Gly Leu Ser Ala Val Gly Ile Phe Xaa Leu Glu Tyr Ser Val Gln 
        115                 120                 125             


Arg Val Arg Gln Leu Arg Glu Glu Phe Asp Gln Gly Leu Asp Val Val 
    130                 135                 140                 


Leu Asp Asp Asn Gln Asn Val His Asp Val Ala Ala Leu Leu Lys Glu 
145                 150                 155                 160 


Phe Phe Arg Asp Met Lys Asp Ser Leu Leu Pro Asp Asp Leu Tyr Met 
                165                 170                 175     


Ser Phe Leu Leu Xaa Ala Xaa Leu Lys Pro Gln Asp Gln Leu Ser Ala 
            180                 185                 190         


Leu Gln Leu Leu Val Tyr Leu Met Pro Pro Cys His Ser Asp Xaa Leu 
        195                 200                 205             


Glu Arg Leu Leu Lys Ala Leu His Lys Ile Xaa Glu Asn Cys Glu Asp 
    210                 215                 220                 


Ser Ile Gly Ile Asp Gly Gln Leu Val Pro Gly Asn Arg Met Xaa Ser 
225                 230                 235                 240 


Xaa Asn Leu Ala Leu Val Phe Gly Ser Ala Leu Leu Lys Lys Gly Lys 
                245                 250                 255     


Phe Gly Lys Arg Glu Ser Arg Lys Xaa Lys Leu Gly Ile Asp His Tyr 
            260                 265                 270         


Val Ala Ser Val Asn Val Val Arg Ala Met Ile Asp Asn Trp Asp Val 
        275                 280                 285             


Leu Phe Gln Val Pro Pro His Ile Gln Arg Gln Val Ala Lys Arg Val 
    290                 295                 300                 


Trp Lys Ser Ser Pro Glu Ala Leu Asp Phe Ile Arg Arg Arg Asn Leu 
305                 310                 315                 320 


Arg Lys Ile Gln Ser Ala Arg Ile Lys Met Glu Glu Asp Ala Leu Leu 
                325                 330                 335     


Ser Asp Pro Val Glu Xaa Ser Ala Glu Ala Arg Ala Ala Val Leu Ala 
            340                 345                 350         


Gln Ser Lys Pro Ser Asp Glu Gly Ser Ser Glu Glu Pro Ala Val Pro 
        355                 360                 365             


Ser Gly Xaa Ala Arg Ser His Asp Asp Glu Glu Gly Ala Gly Asn Pro 
    370                 375                 380                 


Pro Ile Pro Glu Gln Asp Arg Pro Leu Leu Arg Val Pro Arg Glu Lys 
385                 390                 395                 400 


Glu Ala Lys Xaa Gly Val Ser Tyr Phe Phe Pro 
                405                 410     


<210> 2849
<211> 516
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<400> 2849
Met Ser Val Leu Gly Gly Ala Pro Gly His Asn Pro Asp Arg Arg Xaa 
1               5                   10                  15      


Lys Met Val Ser Ile His Ser Leu Ser Glu Leu Glu Arg Leu Lys Leu 
            20                  25                  30          


Gln Glu Xaa Ala Tyr His Glu Leu Val Ala Arg His Phe Leu Ser Glu 
        35                  40                  45              


Phe Lys Pro Asp Arg Ala Leu Pro Ile Asp Arg Pro Asn Xaa Leu Asp 
    50                  55                  60                  


Lys Trp Phe Leu Ile Leu Arg Gly Gln Gln Arg Ala Val Ser His Lys 
65                  70                  75                  80  


Xaa Phe Gly Ile Ser Leu Glu Glu Val Leu Val Asn Glu Phe Xaa Arg 
                85                  90                  95      


Arg Lys His Leu Glu Leu Xaa Ala Xaa Met Gln Val Glu Glu Ala Xaa 
            100                 105                 110         


Gly Gln Ala Ala Gly Arg Arg Arg Gly Asn Val Val Arg Arg Val Phe 
        115                 120                 125             


Gly Arg Ile Arg Arg Phe Phe Ser Arg Arg Arg Asn Glu Pro Xaa Leu 
    130                 135                 140                 


Pro Arg Glu Phe Xaa Arg Arg Gly Arg Arg Gly Ala Val Ser Val Asp 
145                 150                 155                 160 


Ser Leu Ala Glu Leu Glu Asp Gly Ala Leu Leu Leu Gln Xaa Leu Gln 
                165                 170                 175     


Leu Ser Lys Ile Ser Phe Pro Ile Gly Gln Arg Leu Leu Gly Ser Lys 
            180                 185                 190         


Arg Lys Met Ser Leu Asn Pro Ile Ala Lys Gln Ile Pro Gln Val Val 
        195                 200                 205             


Glu Ala Cys Cys Gln Phe Ile Glu Lys His Gly Leu Ser Ala Val Gly 
    210                 215                 220                 


Ile Phe Xaa Leu Glu Tyr Ser Val Gln Arg Val Arg Gln Leu Arg Glu 
225                 230                 235                 240 


Glu Phe Asp Gln Gly Leu Asp Val Val Leu Asp Asp Asn Gln Asn Val 
                245                 250                 255     


His Asp Val Ala Ala Leu Leu Lys Glu Phe Phe Arg Asp Met Lys Asp 
            260                 265                 270         


Ser Leu Leu Pro Asp Asp Leu Tyr Met Ser Phe Leu Leu Xaa Ala Xaa 
        275                 280                 285             


Leu Lys Pro Gln Asp Gln Leu Ser Ala Leu Gln Leu Leu Val Tyr Leu 
    290                 295                 300                 


Met Pro Pro Cys His Ser Asp Xaa Leu Glu Arg Leu Leu Lys Ala Leu 
305                 310                 315                 320 


His Lys Ile Xaa Glu Asn Cys Glu Asp Ser Ile Gly Ile Asp Gly Gln 
                325                 330                 335     


Leu Val Pro Gly Asn Arg Met Xaa Ser Xaa Asn Leu Ala Leu Val Phe 
            340                 345                 350         


Gly Ser Ala Leu Leu Lys Lys Gly Lys Phe Gly Lys Arg Glu Ser Arg 
        355                 360                 365             


Lys Xaa Lys Leu Gly Ile Asp His Tyr Val Ala Ser Val Asn Val Val 
    370                 375                 380                 


Arg Ala Met Ile Asp Asn Trp Asp Val Leu Phe Gln Val Pro Pro His 
385                 390                 395                 400 


Ile Gln Arg Gln Val Ala Lys Arg Val Trp Lys Ser Ser Pro Glu Ala 
                405                 410                 415     


Leu Asp Phe Ile Arg Arg Arg Asn Leu Arg Lys Ile Gln Ser Ala Arg 
            420                 425                 430         


Ile Lys Met Glu Glu Asp Ala Leu Leu Ser Asp Pro Val Glu Xaa Ser 
        435                 440                 445             


Ala Glu Ala Arg Ala Ala Val Leu Ala Gln Ser Lys Pro Ser Asp Glu 
    450                 455                 460                 


Gly Ser Ser Glu Glu Pro Ala Val Pro Ser Gly Xaa Ala Arg Ser His 
465                 470                 475                 480 


Asp Asp Glu Glu Gly Ala Gly Asn Pro Pro Ile Pro Glu Gln Asp Arg 
                485                 490                 495     


Pro Leu Leu Arg Val Pro Arg Glu Lys Glu Ala Lys Xaa Gly Val Ser 
            500                 505                 510         


Tyr Phe Phe Pro 
        515     


<210> 2850
<211> 218
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<400> 2850
Met Val Ser Ile His Ser Leu Ser Glu Leu Glu Arg Leu Lys Leu Gln 
1               5                   10                  15      


Glu Xaa Ala Tyr His Glu Leu Val Ala Arg His Phe Leu Ser Glu Phe 
            20                  25                  30          


Lys Pro Asp Arg Ala Leu Pro Ile Asp Arg Pro Asn Xaa Leu Asp Lys 
        35                  40                  45              


Trp Phe Leu Ile Leu Arg Gly Gln Gln Arg Ala Val Ser His Lys Xaa 
    50                  55                  60                  


Phe Gly Ile Ser Leu Glu Glu Val Leu Val Asn Glu Phe Xaa Arg Arg 
65                  70                  75                  80  


Lys His Leu Glu Leu Xaa Ala Xaa Met Gln Val Glu Glu Ala Xaa Gly 
                85                  90                  95      


Gln Ala Ala Gly Arg Arg Arg Gly Asn Val Val Arg Arg Val Phe Gly 
            100                 105                 110         


Arg Ile Arg Arg Phe Phe Ser Arg Arg Arg Asn Glu Pro Xaa Leu Pro 
        115                 120                 125             


Arg Glu Phe Xaa Arg Arg Gly Arg Arg Gly Ala Val Ser Val Asp Ser 
    130                 135                 140                 


Leu Ala Glu Leu Glu Asp Gly Ala Leu Leu Leu Gln Xaa Leu Gln Leu 
145                 150                 155                 160 


Ser Lys Ile Ser Phe Pro Ile Gly Gln Arg Leu Leu Gly Ser Lys Arg 
                165                 170                 175     


Lys Met Ser Leu Asn Pro Ile Ala Lys Gln Ile Pro Gln Val Val Glu 
            180                 185                 190         


Ala Cys Cys Gln Phe Ile Glu Lys His Gly Leu Ser Ala Val Gly Ile 
        195                 200                 205             


Phe Xaa Leu Glu Tyr Ser Val Gln Arg Val 
    210                 215             


<210> 2851
<211> 1083
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<400> 2851
Met Ser Gln Xaa Gln Asp Tyr Glu Cys Arg Ser His Asn Val Asp Leu 
1               5                   10                  15      


Pro Glu Ser Arg Ile Pro Gly Ser Asn Xaa Arg Leu Glu Trp Val Glu 
            20                  25                  30          


Ile Ile Glu Pro Arg Xaa Arg Glu Arg Met Tyr Ala Asn Leu Val Xaa 
        35                  40                  45              


Gly Glu Cys Val Trp Asp Pro Pro Ala Gly Val Arg Ile Lys Arg Xaa 
    50                  55                  60                  


Ser Glu Asn Gln Trp Trp Glu Leu Phe Asp Pro Asn Xaa Ser Arg Phe 
65                  70                  75                  80  


Tyr Tyr Tyr Asn Ala Ser Xaa Gln Arg Xaa Val Trp His Arg Pro Gln 
                85                  90                  95      


Gly Cys Asp Ile Ile Pro Leu Ala Lys Leu Gln Xaa Leu Lys Gln Asn 
            100                 105                 110         


Xaa Glu Ser Pro Arg Ala Ser Ala Glu Ser Ser Pro Gly Arg Gly Ser 
        115                 120                 125             


Ser Val Ser Arg Glu Gly Ser Xaa Ser Ser Ser Leu Glu Pro Glu Pro 
    130                 135                 140                 


Asp Xaa Glu Lys Ala Gln Glu Leu Pro Ala Arg Ala Gly Arg Pro Ala 
145                 150                 155                 160 


Ala Phe Gly Xaa Val Lys Glu Asp Ser Gly Ser Ser Ser Pro Pro Gly 
                165                 170                 175     


Val Phe Leu Glu Lys Asp Tyr Glu Ile Tyr Arg Asp Tyr Ser Ala Asp 
            180                 185                 190         


Gly Gln Leu Leu His Tyr Arg Xaa Ser Ser Leu Arg Trp Asn Ser Gly 
        195                 200                 205             


Ala Lys Glu Arg Met Leu Ile Lys Val Ala Asp Arg Glu Pro Ser Phe 
    210                 215                 220                 


Leu Ala Ala Gln Gly Asn Gly Tyr Ala Pro Asp Gly Pro Pro Gly Val 
225                 230                 235                 240 


Arg Ser Arg Arg Pro Ser Gly Ser Gln His Ser Pro Ser Leu Gln Xaa 
                245                 250                 255     


Phe Ala Pro Glu Ala Asp Gly Xaa Ile Phe Phe Pro Glu Arg Arg Pro 
            260                 265                 270         


Ser Pro Phe Leu Lys Arg Ala Glu Leu Pro Gly Ser Ser Ser Pro Leu 
        275                 280                 285             


Leu Ala Gln Pro Arg Lys Pro Ser Gly Asp Ser Gln Pro Ser Ser Pro 
    290                 295                 300                 


Arg Tyr Gly Tyr Glu Pro Pro Leu Tyr Glu Glu Pro Pro Val Glu Tyr 
305                 310                 315                 320 


Gln Ala Pro Ile Tyr Asp Glu Pro Pro Met Asp Val Gln Phe Glu Ala 
                325                 330                 335     


Gly Gly Gly Tyr Gln Ala Gly Ser Pro Gln Arg Ser Pro Gly Arg Lys 
            340                 345                 350         


Pro Arg Pro Phe Leu Gln Pro Asn Lys Gln Gly Pro Pro Ser Pro Cys 
        355                 360                 365             


Gln Gln Leu Val Leu Xaa Lys Gln Lys Cys Pro Glu Arg Phe Leu Ser 
    370                 375                 380                 


Leu Glu Tyr Ser Pro Ala Gly Lys Glu Tyr Val Arg Gln Leu Val Tyr 
385                 390                 395                 400 


Val Glu Gln Ala Gly Ser Ser Pro Lys Leu Arg Ala Gly Pro Arg His 
                405                 410                 415     


Lys Tyr Ala Pro Asn Pro Gly Gly Gly Ser Tyr Ser Leu Gln Pro Ser 
            420                 425                 430         


Pro Cys Leu Leu Arg Asp Gln Arg Leu Gly Val Lys Ser Gly Asp Tyr 
        435                 440                 445             


Ser Xaa Met Glu Gly Pro Glu Leu Arg His Ser Gln Pro Pro Xaa Pro 
    450                 455                 460                 


Leu Pro Gln Ala Gln Glu Asp Ala Met Ser Trp Ser Ser Gln Gln Asp 
465                 470                 475                 480 


Xaa Leu Ser Ser Xaa Gly Tyr Ser Pro Gly Xaa Arg Lys Arg Lys Ser 
                485                 490                 495     


Arg Lys Pro Ser Leu Cys Gln Ala Xaa Ser Ala Xaa Pro Xaa Glu Gly 
            500                 505                 510         


Pro Gly Asp Leu Leu Val Glu Gln Pro Leu Ala Glu Glu Gln Pro Pro 
        515                 520                 525             


Cys Gly Xaa Ser Leu Ala Pro Val Lys Arg Ala Glu Gly Glu Ala Glu 
    530                 535                 540                 


Gly Ala Arg Gly Ala Ala Glu Pro Phe Leu Ala Gln Ala Arg Leu Ala 
545                 550                 555                 560 


Trp Glu Ala Gln Gln Ala His Phe His Met Lys Gln Arg Ser Ser Trp 
                565                 570                 575     


Asp Ser Gln Gln Asp Gly Ser Gly Tyr Glu Ser Asp Gly Ala Leu Pro 
            580                 585                 590         


Leu Pro Met Pro Gly Pro Val Val Arg Ala Phe Ser Glu Asp Glu Ala 
        595                 600                 605             


Leu Ala Gln Gln Glu Asn Arg His Trp Arg Arg Gly Xaa Phe Glu Lys 
    610                 615                 620                 


Leu Gly Phe Pro Gln Ile Leu Leu Glu Lys Ser Val Ser Val Gln Xaa 
625                 630                 635                 640 


Asn Leu Ala Ser Pro Glu Pro Tyr Leu His Pro Ser Gln Ser Glu Asp 
                645                 650                 655     


Leu Ala Ala Cys Ala Gln Phe Glu Ser Ser Arg Gln Ser Arg Ser Gly 
            660                 665                 670         


Val Pro Ser Ser Ser Cys Val Phe Pro Xaa Phe Xaa Leu Arg Lys Pro 
        675                 680                 685             


Ser Ser Glu Xaa Asp Ile Glu Asn Trp Ala Ser Lys His Phe Asn Lys 
    690                 695                 700                 


His Xaa Gln Gly Leu Phe Arg Arg Lys Val Ser Ile Ala Asn Met Leu 
705                 710                 715                 720 


Ala Trp Ser Ser Glu Ser Ile Lys Lys Pro Met Ile Val Xaa Ser Asp 
                725                 730                 735     


Arg His Val Lys Lys Glu Ala Cys Glu Leu Phe Lys Leu Ile Gln Met 
            740                 745                 750         


Tyr Met Gly Asp Arg Arg Ala Lys Ala Asp Pro Leu His Val Ala Leu 
        755                 760                 765             


Glu Val Ala Xaa Lys Gly Trp Ser Val Gln Gly Leu Arg Asp Glu Leu 
    770                 775                 780                 


Tyr Ile Gln Leu Cys Arg Gln Xaa Xaa Glu Asn Phe Arg Leu Glu Ser 
785                 790                 795                 800 


Leu Ala Arg Gly Trp Glu Leu Met Ala Ile Cys Leu Ala Phe Phe Pro 
                805                 810                 815     


Pro Xaa Pro Lys Phe His Ser Tyr Leu Glu Gly Tyr Ile Tyr Arg His 
            820                 825                 830         


Met Asp Pro Val Asn Asp Xaa Lys Gly Val Ala Ile Ser Xaa Tyr Ala 
        835                 840                 845             


Lys Tyr Cys Tyr His Lys Leu Gln Lys Ala Ala Leu Xaa Gly Ala Lys 
    850                 855                 860                 


Lys Gly Leu Lys Lys Pro Asn Val Glu Glu Ile Arg His Ala Lys Asn 
865                 870                 875                 880 


Ala Val Phe Ser Pro Ser Met Phe Gly Ser Ala Leu Gln Glu Val Met 
                885                 890                 895     


Gly Met Gln Arg Glu Arg Tyr Pro Glu Arg Gln Leu Pro Trp Val Gln 
            900                 905                 910         


Xaa Arg Leu Ser Glu Glu Val Leu Ala Leu Asn Gly Asp Gln Xaa Glu 
        915                 920                 925             


Gly Ile Phe Arg Val Pro Gly Asp Ile Asp Glu Val Asn Ala Leu Lys 
    930                 935                 940                 


Leu Gln Val Asp Gln Trp Lys Val Pro Xaa Gly Leu Glu Asp Pro His 
945                 950                 955                 960 


Val Pro Ala Ser Leu Leu Lys Leu Trp Tyr Arg Glu Leu Glu Glu Pro 
                965                 970                 975     


Leu Ile Pro His Glu Phe Tyr Glu Gln Cys Ile Ala His Tyr Asp Ser 
            980                 985                 990         


Pro Glu Ala Ala Val Ala Val Val  His Ala Leu Pro Arg  Ile Asn Arg 
        995                 1000                 1005             


Met Val  Leu Cys Tyr Leu Ile  Arg Phe Leu Gln Val  Phe Val Gln 
    1010                 1015                 1020             


Pro Ala  Asn Val Ala Val Xaa  Lys Met Asp Val Ser  Asn Leu Ala 
    1025                 1030                 1035             


Met Val  Met Ala Pro Asn Cys  Leu Arg Cys Gln Ser  Asp Asp Pro 
    1040                 1045                 1050             


Arg Val  Ile Phe Glu Asn Xaa  Arg Lys Glu Met Ser  Phe Leu Arg 
    1055                 1060                 1065             


Val Leu  Ile Gln His Leu Asp  Xaa Ser Phe Met Glu  Gly Val Leu 
    1070                 1075                 1080             


<210> 2852
<211> 1114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1091)..(1091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1107)..(1107)
<223> Selenocysteine

<400> 2852
Met Ser Gln Xaa Gln Asp Tyr Glu Cys Arg Ser His Asn Val Asp Leu 
1               5                   10                  15      


Pro Glu Ser Arg Ile Pro Gly Ser Asn Xaa Arg Leu Glu Trp Val Glu 
            20                  25                  30          


Ile Ile Glu Pro Arg Xaa Arg Glu Arg Met Tyr Ala Asn Leu Val Xaa 
        35                  40                  45              


Gly Glu Cys Val Trp Asp Pro Pro Ala Gly Val Arg Ile Lys Arg Xaa 
    50                  55                  60                  


Ser Glu Asn Gln Trp Trp Glu Leu Phe Asp Pro Asn Xaa Ser Arg Phe 
65                  70                  75                  80  


Tyr Tyr Tyr Asn Ala Ser Xaa Gln Arg Xaa Val Trp His Arg Pro Gln 
                85                  90                  95      


Gly Cys Asp Ile Ile Pro Leu Ala Lys Leu Gln Xaa Leu Lys Gln Asn 
            100                 105                 110         


Xaa Glu Ser Pro Arg Ala Ser Ala Glu Ser Ser Pro Gly Arg Gly Ser 
        115                 120                 125             


Ser Val Ser Arg Glu Gly Ser Xaa Ser Ser Ser Leu Glu Pro Glu Pro 
    130                 135                 140                 


Asp Xaa Glu Lys Ala Gln Glu Leu Pro Ala Arg Ala Gly Arg Pro Ala 
145                 150                 155                 160 


Ala Phe Gly Xaa Val Lys Glu Asp Ser Gly Ser Ser Ser Pro Pro Gly 
                165                 170                 175     


Val Phe Leu Glu Lys Asp Tyr Glu Ile Tyr Arg Asp Tyr Ser Ala Asp 
            180                 185                 190         


Gly Gln Leu Leu His Tyr Arg Xaa Ser Ser Leu Arg Trp Asn Ser Gly 
        195                 200                 205             


Ala Lys Glu Arg Met Leu Ile Lys Val Ala Asp Arg Glu Pro Ser Phe 
    210                 215                 220                 


Leu Ala Ala Gln Gly Asn Gly Tyr Ala Pro Asp Gly Pro Pro Gly Val 
225                 230                 235                 240 


Arg Ser Arg Arg Pro Ser Gly Ser Gln His Ser Pro Ser Leu Gln Xaa 
                245                 250                 255     


Phe Ala Pro Glu Ala Asp Gly Xaa Ile Phe Phe Pro Glu Arg Arg Pro 
            260                 265                 270         


Ser Pro Phe Leu Lys Arg Ala Glu Leu Pro Gly Ser Ser Ser Pro Leu 
        275                 280                 285             


Leu Ala Gln Pro Arg Lys Pro Ser Gly Asp Ser Gln Pro Ser Ser Pro 
    290                 295                 300                 


Arg Tyr Gly Tyr Glu Pro Pro Leu Tyr Glu Glu Pro Pro Val Glu Tyr 
305                 310                 315                 320 


Gln Ala Pro Ile Tyr Asp Glu Pro Pro Met Asp Val Gln Phe Glu Ala 
                325                 330                 335     


Gly Gly Gly Tyr Gln Ala Gly Ser Pro Gln Arg Ser Pro Gly Arg Lys 
            340                 345                 350         


Pro Arg Pro Phe Leu Gln Pro Asn Lys Gln Gly Pro Pro Ser Pro Cys 
        355                 360                 365             


Gln Gln Leu Val Leu Xaa Lys Gln Lys Cys Pro Glu Arg Phe Leu Ser 
    370                 375                 380                 


Leu Glu Tyr Ser Pro Ala Gly Lys Glu Tyr Val Arg Gln Leu Val Tyr 
385                 390                 395                 400 


Val Glu Gln Ala Gly Ser Ser Pro Lys Leu Arg Ala Gly Pro Arg His 
                405                 410                 415     


Lys Tyr Ala Pro Asn Pro Gly Gly Gly Ser Tyr Ser Leu Gln Pro Ser 
            420                 425                 430         


Pro Cys Leu Leu Arg Asp Gln Arg Leu Gly Val Lys Ser Gly Asp Tyr 
        435                 440                 445             


Ser Xaa Met Glu Gly Pro Glu Leu Arg His Ser Gln Pro Pro Xaa Pro 
    450                 455                 460                 


Leu Pro Gln Ala Gln Glu Asp Ala Met Ser Trp Ser Ser Gln Gln Asp 
465                 470                 475                 480 


Xaa Leu Ser Ser Xaa Gly Tyr Ser Pro Gly Xaa Arg Lys Arg Lys Ser 
                485                 490                 495     


Arg Lys Pro Ser Leu Cys Gln Ala Xaa Ser Ala Xaa Pro Xaa Glu Gly 
            500                 505                 510         


Pro Gly Asp Leu Leu Val Glu Gln Pro Leu Ala Glu Glu Gln Pro Pro 
        515                 520                 525             


Cys Gly Xaa Ser Leu Ala Pro Val Lys Arg Ala Glu Gly Glu Ala Glu 
    530                 535                 540                 


Gly Ala Arg Gly Ala Ala Glu Pro Phe Leu Ala Gln Ala Arg Leu Ala 
545                 550                 555                 560 


Trp Glu Ala Gln Gln Ala His Phe His Met Lys Gln Arg Ser Ser Trp 
                565                 570                 575     


Asp Ser Gln Gln Asp Gly Ser Gly Tyr Glu Ser Asp Gly Ala Leu Pro 
            580                 585                 590         


Leu Pro Met Pro Gly Pro Val Val Arg Ala Phe Ser Glu Asp Glu Ala 
        595                 600                 605             


Leu Ala Gln Gln Glu Asn Arg His Trp Arg Arg Gly Xaa Phe Glu Lys 
    610                 615                 620                 


Leu Gly Phe Pro Gln Ile Leu Leu Glu Lys Ser Val Ser Val Gln Xaa 
625                 630                 635                 640 


Asn Leu Ala Ser Pro Glu Pro Tyr Leu His Pro Ser Gln Ser Glu Asp 
                645                 650                 655     


Leu Ala Ala Cys Ala Gln Phe Glu Ser Ser Arg Gln Ser Arg Ser Gly 
            660                 665                 670         


Val Pro Ser Ser Ser Cys Val Phe Pro Xaa Phe Xaa Leu Arg Lys Pro 
        675                 680                 685             


Ser Ser Glu Xaa Asp Ile Glu Asn Trp Ala Ser Lys His Phe Asn Lys 
    690                 695                 700                 


His Xaa Gln Gly Leu Phe Arg Arg Lys Val Ser Ile Ala Asn Met Leu 
705                 710                 715                 720 


Ala Trp Ser Ser Glu Ser Ile Lys Lys Pro Met Ile Val Xaa Ser Asp 
                725                 730                 735     


Arg His Val Lys Lys Glu Ala Cys Glu Leu Phe Lys Leu Ile Gln Met 
            740                 745                 750         


Tyr Met Gly Asp Arg Arg Ala Lys Ala Asp Pro Leu His Val Ala Leu 
        755                 760                 765             


Glu Val Ala Xaa Lys Gly Trp Ser Val Gln Gly Leu Arg Asp Glu Leu 
    770                 775                 780                 


Tyr Ile Gln Leu Cys Arg Gln Xaa Xaa Glu Asn Phe Arg Leu Glu Ser 
785                 790                 795                 800 


Leu Ala Arg Gly Trp Glu Leu Met Ala Ile Cys Leu Ala Phe Phe Pro 
                805                 810                 815     


Pro Xaa Pro Lys Phe His Ser Tyr Leu Glu Gly Tyr Ile Tyr Arg His 
            820                 825                 830         


Met Asp Pro Val Asn Asp Xaa Lys Val Xaa Gln His Ile Lys Glu Leu 
        835                 840                 845             


Leu Glu Arg Asn Xaa Lys Lys Lys Ser Lys Leu Arg Lys Lys Pro Lys 
    850                 855                 860                 


Pro Tyr Val Glu Glu Pro Asp Gly Val Ala Ile Ser Xaa Tyr Ala Lys 
865                 870                 875                 880 


Tyr Cys Tyr His Lys Leu Gln Lys Ala Ala Leu Xaa Gly Ala Lys Lys 
                885                 890                 895     


Gly Leu Lys Lys Pro Asn Val Glu Glu Ile Arg His Ala Lys Asn Ala 
            900                 905                 910         


Val Phe Ser Pro Ser Met Phe Gly Ser Ala Leu Gln Glu Val Met Gly 
        915                 920                 925             


Met Gln Arg Glu Arg Tyr Pro Glu Arg Gln Leu Pro Trp Val Gln Xaa 
    930                 935                 940                 


Arg Leu Ser Glu Glu Val Leu Ala Leu Asn Gly Asp Gln Xaa Glu Gly 
945                 950                 955                 960 


Ile Phe Arg Val Pro Gly Asp Ile Asp Glu Val Asn Ala Leu Lys Leu 
                965                 970                 975     


Gln Val Asp Gln Trp Lys Val Pro Xaa Gly Leu Glu Asp Pro His Val 
            980                 985                 990         


Pro Ala Ser Leu Leu Lys Leu Trp  Tyr Arg Glu Leu Glu  Glu Pro Leu 
        995                 1000                 1005             


Ile Pro  His Glu Phe Tyr Glu  Gln Cys Ile Ala His  Tyr Asp Ser 
    1010                 1015                 1020             


Pro Glu  Ala Ala Val Ala Val  Val His Ala Leu Pro  Arg Ile Asn 
    1025                 1030                 1035             


Arg Met  Val Leu Cys Tyr Leu  Ile Arg Phe Leu Gln  Val Phe Val 
    1040                 1045                 1050             


Gln Pro  Ala Asn Val Ala Val  Xaa Lys Met Asp Val  Ser Asn Leu 
    1055                 1060                 1065             


Ala Met  Val Met Ala Pro Asn  Cys Leu Arg Cys Gln  Ser Asp Asp 
    1070                 1075                 1080             


Pro Arg  Val Ile Phe Glu Asn  Xaa Arg Lys Glu Met  Ser Phe Leu 
    1085                 1090                 1095             


Arg Val  Leu Ile Gln His Leu  Asp Xaa Ser Phe Met  Glu Gly Val 
    1100                 1105                 1110             


Leu 
    


<210> 2853
<211> 214
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<400> 2853
Glu Lys Arg Gln Ala Lys Phe Met Glu His Lys Leu Lys Cys Xaa Lys 
1               5                   10                  15      


Ala Arg Asn Glu Tyr Leu Leu Ser Leu Ala Ser Val Asn Ala Ala Val 
            20                  25                  30          


Ser Asn Tyr Tyr Leu His Asp Val Leu Asp Leu Met Asp Cys Cys Asp 
        35                  40                  45              


Xaa Gly Phe His Leu Ala Leu Gly Gln Val Leu Arg Ser Tyr Xaa Ala 
    50                  55                  60                  


Ala Glu Ser Arg Xaa Gln Ala Ser Gln Val Gln Gly Leu Gly Ser Leu 
65                  70                  75                  80  


Glu Glu Ala Val Glu Ala Leu Asp Pro Pro Gly Asp Lys Ala Lys Val 
                85                  90                  95      


Leu Glu Val His Ala Xaa Val Phe Cys Pro Pro Leu Arg Phe Asp Tyr 
            100                 105                 110         


His Pro His Asp Gly Asp Glu Val Ala Glu Ile Cys Val Glu Met Glu 
        115                 120                 125             


Leu Arg Asp Glu Ile Leu Pro Arg Ala Gln Asn Ile Gln Ser Arg Leu 
    130                 135                 140                 


Asp Arg Gln Xaa Ile Glu Xaa Glu Glu Xaa Ser Pro Ser Xaa Glu Ser 
145                 150                 155                 160 


Leu Lys Ser Xaa Ser Ser Asp Pro Gly Ser Arg Gln Ala Gly Arg Arg 
                165                 170                 175     


Arg Gly Gln Gln Gln Glu Xaa Glu Xaa Phe Tyr Leu Xaa Lys Leu Gln 
            180                 185                 190         


Glu Tyr Leu Ser Gly Arg Ser Ile Leu Ala Lys Leu Gln Ala Lys His 
        195                 200                 205             


Glu Lys Leu Gln Glu Ala 
    210                 


<210> 2854
<211> 925
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(921)
<223> Selenocysteine

<400> 2854
Met Ala Ala His Gly Lys Leu Arg Arg Glu Arg Gly Leu Gln Ala Glu 
1               5                   10                  15      


Tyr Glu Xaa Gln Val Lys Glu Met Arg Trp Gln Leu Ser Glu Gln Leu 
            20                  25                  30          


Arg Cys Leu Glu Leu Gln Gly Glu Leu Arg Arg Glu Leu Leu Gln Glu 
        35                  40                  45              


Leu Ala Glu Phe Met Arg Arg Arg Ala Glu Val Glu Leu Glu Tyr Ser 
    50                  55                  60                  


Arg Gly Leu Glu Lys Leu Ala Glu Arg Phe Ser Ser Arg Gly Gly Arg 
65                  70                  75                  80  


Leu Gly Ser Ser Arg Glu His Gln Ser Phe Arg Lys Glu Pro Ser Leu 
                85                  90                  95      


Leu Ser Pro Leu His Cys Trp Ala Val Leu Leu Gln His Xaa Arg Gln 
            100                 105                 110         


Gln Ser Arg Glu Ser Ala Ala Leu Ser Glu Val Leu Ala Gly Pro Leu 
        115                 120                 125             


Ala Gln Arg Leu Ser His Ile Ala Glu Asp Val Gly Arg Leu Val Lys 
    130                 135                 140                 


Lys Ala Lys Lys Xaa Tyr Gln Ala Tyr His Met Glu Ser Val Asn Ala 
145                 150                 155                 160 


Glu Ala Lys Leu Arg Glu Ala Glu Arg Gln Glu Glu Lys Arg Ala Gly 
                165                 170                 175     


Arg Ser Val Pro Xaa Xaa Xaa Ala Gly Ala Xaa Glu Ala Gly Pro Leu 
            180                 185                 190         


Arg Lys Ser Ser Leu Lys Lys Gly Gly Arg Leu Val Glu Lys Arg Gln 
        195                 200                 205             


Ala Lys Phe Met Glu His Lys Leu Lys Cys Xaa Lys Ala Arg Asn Glu 
    210                 215                 220                 


Tyr Leu Leu Ser Leu Ala Ser Val Asn Ala Ala Val Ser Asn Tyr Tyr 
225                 230                 235                 240 


Leu His Asp Val Leu Asp Leu Met Asp Cys Cys Asp Xaa Gly Phe His 
                245                 250                 255     


Leu Ala Leu Gly Gln Val Leu Arg Ser Tyr Xaa Ala Ala Glu Ser Arg 
            260                 265                 270         


Xaa Gln Ala Ser Gln Val Gln Gly Leu Gly Ser Leu Glu Glu Ala Val 
        275                 280                 285             


Glu Ala Leu Asp Pro Pro Gly Asp Lys Ala Lys Val Leu Glu Val His 
    290                 295                 300                 


Ala Xaa Val Phe Cys Pro Pro Leu Arg Phe Asp Tyr His Pro His Asp 
305                 310                 315                 320 


Gly Asp Glu Val Ala Glu Ile Cys Val Glu Met Glu Leu Arg Asp Glu 
                325                 330                 335     


Ile Leu Pro Arg Ala Gln Asn Ile Gln Ser Arg Leu Asp Arg Gln Xaa 
            340                 345                 350         


Ile Glu Xaa Glu Glu Val Asn Lys Xaa Leu Lys Ala Xaa Leu Gln Ala 
        355                 360                 365             


Leu Leu Glu Val Val Ala Ser Asp Asp Gly Asp Val Leu Asp Ser Phe 
    370                 375                 380                 


Gln Xaa Ser Pro Ser Xaa Glu Ser Leu Lys Ser Xaa Ser Ser Asp Pro 
385                 390                 395                 400 


Gly Ser Arg Gln Ala Gly Arg Arg Arg Gly Gln Gln Gln Glu Xaa Glu 
                405                 410                 415     


Xaa Phe Tyr Leu Xaa Lys Leu Gln Glu Tyr Leu Ser Gly Arg Ser Ile 
            420                 425                 430         


Leu Ala Lys Leu Gln Ala Lys His Glu Lys Leu Gln Glu Ala Leu Gln 
        435                 440                 445             


Arg Gly Asp Lys Glu Glu Gln Glu Val Ser Trp Xaa Gln Tyr Xaa Gln 
    450                 455                 460                 


Arg Lys Phe Gln Lys Ser Arg Gln Pro Arg Pro Ser Ser Gln Tyr Asn 
465                 470                 475                 480 


Gln Arg Leu Phe Gly Gly Asp Met Glu Lys Phe Ile Gln Ser Ser Gly 
                485                 490                 495     


Gln Pro Val Pro Leu Val Val Glu Ser Cys Ile Arg Phe Ile Asn Leu 
            500                 505                 510         


Asn Gly Leu Gln His Glu Gly Ile Phe Arg Val Ser Gly Ala Gln Leu 
        515                 520                 525             


Arg Val Ser Glu Ile Arg Asp Ala Phe Glu Arg Gly Glu Asp Pro Leu 
    530                 535                 540                 


Val Glu Gly Cys Xaa Ala His Asp Leu Asp Ser Val Ala Gly Val Leu 
545                 550                 555                 560 


Lys Leu Tyr Phe Arg Ser Leu Glu Pro Pro Leu Phe Pro Pro Asp Leu 
                565                 570                 575     


Phe Gly Glu Leu Leu Ala Ser Ser Glu Leu Glu Ala Xaa Ala Glu Arg 
            580                 585                 590         


Val Glu His Val Ser Arg Leu Leu Trp Arg Leu Pro Ala Pro Val Leu 
        595                 600                 605             


Val Val Leu Arg Tyr Leu Phe Xaa Phe Leu Asn His Leu Ala Gln Tyr 
    610                 615                 620                 


Ser Asp Glu Asn Met Met Asp Pro Tyr Asn Leu Ala Val Cys Phe Gly 
625                 630                 635                 640 


Pro Xaa Leu Leu Pro Val Pro Ala Gly Gln Asp Pro Val Ala Leu Gln 
                645                 650                 655     


Gly Arg Val Asn Gln Leu Val Gln Xaa Leu Ile Val Gln Pro Asp Arg 
            660                 665                 670         


Val Phe Pro Pro Leu Xaa Ser Leu Pro Gly Pro Val Tyr Glu Lys Cys 
        675                 680                 685             


Met Ala Pro Pro Ser Ala Ser Cys Leu Gly Asp Ala Gln Leu Glu Ser 
    690                 695                 700                 


Leu Gly Ala Asp Asn Glu Pro Glu Leu Glu Ala Glu Met Pro Ala Gln 
705                 710                 715                 720 


Glu Asp Asp Leu Glu Gly Val Val Glu Ala Val Ala Cys Phe Ala Tyr 
                725                 730                 735     


Xaa Gly Arg Xaa Ala Gln Glu Leu Ser Phe Arg Arg Gly Asp Val Leu 
            740                 745                 750         


Arg Leu His Glu Arg Ala Ser Ser Asp Trp Trp Arg Gly Glu His Asn 
        755                 760                 765             


Gly Met Arg Gly Leu Ile Pro His Lys Tyr Ile Xaa Leu Pro Ala Gly 
    770                 775                 780                 


Xaa Glu Lys Gln Val Val Gly Ala Gly Leu Gln Xaa Ala Gly Glu Ser 
785                 790                 795                 800 


Gly Ser Ser Pro Glu Gly Leu Leu Ala Ser Glu Leu Val His Arg Pro 
                805                 810                 815     


Glu Pro Cys Xaa Ser Pro Glu Ala Met Gly Pro Ser Gly His Arg Arg 
            820                 825                 830         


Arg Cys Leu Val Pro Ala Ser Pro Glu Gln His Val Glu Val Asp Lys 
        835                 840                 845             


Ala Val Ala Gln Asn Met Asp Ser Val Phe Lys Glu Leu Leu Gly Lys 
    850                 855                 860                 


Xaa Ser Val Arg Gln Gly Leu Gly Pro Ala Ser Xaa Xaa Ser Pro Ser 
865                 870                 875                 880 


Pro Gly Pro Arg Ser Pro Lys Ala Pro Pro Ser Ser Arg Leu Gly Arg 
                885                 890                 895     


Asn Lys Gly Phe Ser Arg Gly Pro Gly Ala Pro Ala Ser Pro Ser Ala 
            900                 905                 910         


Ser His Pro Gln Gly Leu Asp Xaa Xaa Pro Lys Pro His 
        915                 920                 925 


<210> 2855
<211> 986
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(982)
<223> Selenocysteine

<400> 2855
Met Ala Ala His Gly Lys Leu Arg Arg Glu Arg Gly Leu Gln Ala Glu 
1               5                   10                  15      


Tyr Glu Xaa Gln Val Lys Glu Met Arg Trp Gln Leu Ser Glu Gln Leu 
            20                  25                  30          


Arg Cys Leu Glu Leu Gln Gly Glu Leu Arg Arg Glu Leu Leu Gln Glu 
        35                  40                  45              


Leu Ala Glu Phe Met Arg Arg Arg Ala Glu Val Glu Leu Glu Tyr Ser 
    50                  55                  60                  


Arg Gly Leu Glu Lys Leu Ala Glu Arg Phe Ser Ser Arg Gly Gly Arg 
65                  70                  75                  80  


Leu Gly Ser Ser Arg Glu His Gln Ser Phe Arg Lys Glu Pro Ser Leu 
                85                  90                  95      


Leu Ser Pro Leu His Cys Trp Ala Val Leu Leu Gln His Xaa Arg Gln 
            100                 105                 110         


Gln Ser Arg Glu Ser Ala Ala Leu Ser Glu Val Leu Ala Gly Pro Leu 
        115                 120                 125             


Ala Gln Arg Leu Ser His Ile Ala Glu Asp Val Gly Arg Leu Val Lys 
    130                 135                 140                 


Lys Ser Arg Asp Leu Glu Gln Gln Leu Gln Asp Glu Leu Leu Glu Val 
145                 150                 155                 160 


Val Ser Glu Leu Gln Xaa Ala Lys Lys Xaa Tyr Gln Ala Tyr His Met 
                165                 170                 175     


Glu Ser Val Asn Ala Glu Ala Lys Leu Arg Glu Ala Glu Arg Gln Glu 
            180                 185                 190         


Glu Lys Arg Ala Gly Arg Ser Val Pro Xaa Xaa Xaa Ala Gly Ala Xaa 
        195                 200                 205             


Glu Ala Gly Pro Leu Arg Lys Ser Ser Leu Lys Lys Gly Gly Arg Leu 
    210                 215                 220                 


Val Glu Lys Leu Trp Pro Pro Gln Arg Pro Val Ala Ala Ser Ser Cys 
225                 230                 235                 240 


Ala Pro Val Cys Trp Leu Gln Ala Gly Phe Leu Val His Pro Pro Trp 
                245                 250                 255     


Trp Gly Ala Met Cys Ala Pro Ser Xaa His Gln Arg Gln Ala Lys Phe 
            260                 265                 270         


Met Glu His Lys Leu Lys Cys Xaa Lys Ala Arg Asn Glu Tyr Leu Leu 
        275                 280                 285             


Ser Leu Ala Ser Val Asn Ala Ala Val Ser Asn Tyr Tyr Leu His Asp 
    290                 295                 300                 


Val Leu Asp Leu Met Asp Cys Cys Asp Xaa Gly Phe His Leu Ala Leu 
305                 310                 315                 320 


Gly Gln Val Leu Arg Ser Tyr Xaa Ala Ala Glu Ser Arg Xaa Gln Ala 
                325                 330                 335     


Ser Gln Val Gln Gly Leu Gly Ser Leu Glu Glu Ala Val Glu Ala Leu 
            340                 345                 350         


Asp Pro Pro Gly Asp Lys Ala Lys Val Leu Glu Val His Ala Xaa Val 
        355                 360                 365             


Phe Cys Pro Pro Leu Arg Phe Asp Tyr His Pro His Asp Gly Asp Glu 
    370                 375                 380                 


Val Ala Glu Ile Cys Val Glu Met Glu Leu Arg Asp Glu Ile Leu Pro 
385                 390                 395                 400 


Arg Ala Gln Asn Ile Gln Ser Arg Leu Asp Arg Gln Xaa Ile Glu Xaa 
                405                 410                 415     


Glu Glu Val Asn Lys Xaa Leu Lys Ala Xaa Leu Gln Ala Leu Leu Glu 
            420                 425                 430         


Val Val Ala Ser Asp Asp Gly Asp Val Leu Asp Ser Phe Gln Xaa Ser 
        435                 440                 445             


Pro Ser Xaa Glu Ser Leu Lys Ser Xaa Ser Ser Asp Pro Gly Ser Arg 
    450                 455                 460                 


Gln Ala Gly Arg Arg Arg Gly Gln Gln Gln Glu Xaa Glu Xaa Phe Tyr 
465                 470                 475                 480 


Leu Xaa Lys Leu Gln Glu Tyr Leu Ser Gly Arg Ser Ile Leu Ala Lys 
                485                 490                 495     


Leu Gln Ala Lys His Glu Lys Leu Gln Glu Ala Leu Gln Arg Gly Asp 
            500                 505                 510         


Lys Glu Glu Gln Glu Val Ser Trp Xaa Gln Tyr Xaa Gln Arg Lys Phe 
        515                 520                 525             


Gln Lys Ser Arg Gln Pro Arg Pro Ser Ser Gln Tyr Asn Gln Arg Leu 
    530                 535                 540                 


Phe Gly Gly Asp Met Glu Lys Phe Ile Gln Ser Ser Gly Gln Pro Val 
545                 550                 555                 560 


Pro Leu Val Val Glu Ser Cys Ile Arg Phe Ile Asn Leu Asn Gly Leu 
                565                 570                 575     


Gln His Glu Gly Ile Phe Arg Val Ser Gly Ala Gln Leu Arg Val Ser 
            580                 585                 590         


Glu Ile Arg Asp Ala Phe Glu Arg Gly Glu Asp Pro Leu Val Glu Gly 
        595                 600                 605             


Cys Xaa Ala His Asp Leu Asp Ser Val Ala Gly Val Leu Lys Leu Tyr 
    610                 615                 620                 


Phe Arg Ser Leu Glu Pro Pro Leu Phe Pro Pro Asp Leu Phe Gly Glu 
625                 630                 635                 640 


Leu Leu Ala Ser Ser Glu Leu Glu Ala Xaa Ala Glu Arg Val Glu His 
                645                 650                 655     


Val Ser Arg Leu Leu Trp Arg Leu Pro Ala Pro Val Leu Val Val Leu 
            660                 665                 670         


Arg Tyr Leu Phe Xaa Phe Leu Asn His Leu Ala Gln Tyr Ser Asp Glu 
        675                 680                 685             


Asn Met Met Asp Pro Tyr Asn Leu Ala Val Cys Phe Gly Pro Xaa Leu 
    690                 695                 700                 


Leu Pro Val Pro Ala Gly Gln Asp Pro Val Ala Leu Gln Gly Arg Val 
705                 710                 715                 720 


Asn Gln Leu Val Gln Xaa Leu Ile Val Gln Pro Asp Arg Val Phe Pro 
                725                 730                 735     


Pro Leu Xaa Ser Leu Pro Gly Pro Val Tyr Glu Lys Cys Met Ala Pro 
            740                 745                 750         


Pro Ser Ala Ser Cys Leu Gly Asp Ala Gln Leu Glu Ser Leu Gly Ala 
        755                 760                 765             


Asp Asn Glu Pro Glu Leu Glu Ala Glu Met Pro Ala Gln Glu Asp Asp 
    770                 775                 780                 


Leu Glu Gly Val Val Glu Ala Val Ala Cys Phe Ala Tyr Xaa Gly Arg 
785                 790                 795                 800 


Xaa Ala Gln Glu Leu Ser Phe Arg Arg Gly Asp Val Leu Arg Leu His 
                805                 810                 815     


Glu Arg Ala Ser Ser Asp Trp Trp Arg Gly Glu His Asn Gly Met Arg 
            820                 825                 830         


Gly Leu Ile Pro His Lys Tyr Ile Xaa Leu Pro Ala Gly Xaa Glu Lys 
        835                 840                 845             


Gln Val Val Gly Ala Gly Leu Gln Xaa Ala Gly Glu Ser Gly Ser Ser 
    850                 855                 860                 


Pro Glu Gly Leu Leu Ala Ser Glu Leu Val His Arg Pro Glu Pro Cys 
865                 870                 875                 880 


Xaa Ser Pro Glu Ala Met Gly Pro Ser Gly His Arg Arg Arg Cys Leu 
                885                 890                 895     


Val Pro Ala Ser Pro Glu Gln His Val Glu Val Asp Lys Ala Val Ala 
            900                 905                 910         


Gln Asn Met Asp Ser Val Phe Lys Glu Leu Leu Gly Lys Xaa Ser Val 
        915                 920                 925             


Arg Gln Gly Leu Gly Pro Ala Ser Xaa Xaa Ser Pro Ser Pro Gly Pro 
    930                 935                 940                 


Arg Ser Pro Lys Ala Pro Pro Ser Ser Arg Leu Gly Arg Asn Lys Gly 
945                 950                 955                 960 


Phe Ser Arg Gly Pro Gly Ala Pro Ala Ser Pro Ser Ala Ser His Pro 
                965                 970                 975     


Gln Gly Leu Asp Xaa Xaa Pro Lys Pro His 
            980                 985     


<210> 2856
<211> 625
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<400> 2856
Met Ala Ala His Gly Lys Leu Arg Arg Glu Arg Gly Leu Gln Ala Glu 
1               5                   10                  15      


Tyr Glu Xaa Gln Val Lys Glu Met Arg Trp Gln Leu Ser Glu Gln Leu 
            20                  25                  30          


Arg Cys Leu Glu Leu Gln Gly Glu Leu Arg Arg Glu Leu Leu Gln Glu 
        35                  40                  45              


Leu Ala Glu Phe Met Arg Arg Arg Ala Glu Val Glu Leu Glu Tyr Ser 
    50                  55                  60                  


Arg Gly Leu Glu Lys Leu Ala Glu Arg Phe Ser Ser Arg Gly Gly Arg 
65                  70                  75                  80  


Leu Gly Ser Ser Arg Glu His Gln Ser Phe Arg Lys Glu Pro Ser Leu 
                85                  90                  95      


Leu Ser Pro Leu His Cys Trp Ala Val Leu Leu Gln His Xaa Arg Gln 
            100                 105                 110         


Gln Ser Arg Glu Ser Ala Ala Leu Ser Glu Val Leu Ala Gly Pro Leu 
        115                 120                 125             


Ala Gln Arg Leu Ser His Ile Ala Glu Asp Val Gly Arg Leu Val Lys 
    130                 135                 140                 


Lys Ser Arg Asp Leu Glu Gln Gln Leu Gln Asp Glu Leu Leu Glu Val 
145                 150                 155                 160 


Val Ser Glu Leu Gln Xaa Ala Lys Lys Xaa Tyr Gln Ala Tyr His Met 
                165                 170                 175     


Glu Ser Val Asn Ala Glu Ala Lys Leu Arg Glu Ala Glu Arg Gln Glu 
            180                 185                 190         


Glu Lys Arg Ala Gly Arg Ser Val Pro Xaa Xaa Xaa Ala Gly Ala Xaa 
        195                 200                 205             


Glu Ala Gly Pro Leu Arg Lys Ser Ser Leu Lys Lys Gly Gly Arg Leu 
    210                 215                 220                 


Val Glu Lys Arg Gln Ala Lys Phe Met Glu His Lys Leu Lys Cys Xaa 
225                 230                 235                 240 


Lys Ala Arg Asn Glu Tyr Leu Leu Ser Leu Ala Ser Val Asn Ala Ala 
                245                 250                 255     


Val Ser Asn Tyr Tyr Leu His Asp Val Leu Asp Leu Met Asp Cys Cys 
            260                 265                 270         


Asp Xaa Gly Phe His Leu Ala Leu Gly Gln Val Leu Arg Ser Tyr Xaa 
        275                 280                 285             


Ala Ala Glu Ser Arg Xaa Gln Ala Ser Gln Val Gln Gly Leu Gly Ser 
    290                 295                 300                 


Leu Glu Glu Ala Val Glu Ala Leu Asp Pro Pro Gly Asp Lys Ala Lys 
305                 310                 315                 320 


Val Leu Glu Val His Ala Xaa Val Phe Cys Pro Pro Leu Arg Phe Asp 
                325                 330                 335     


Tyr His Pro His Asp Gly Asp Glu Val Ala Glu Ile Cys Val Glu Met 
            340                 345                 350         


Glu Leu Arg Asp Glu Ile Leu Pro Arg Ala Gln Asn Ile Gln Ser Arg 
        355                 360                 365             


Leu Asp Arg Gln Xaa Ile Glu Xaa Glu Glu Val Asn Lys Xaa Leu Lys 
    370                 375                 380                 


Ala Xaa Leu Gln Ala Leu Leu Glu Val Val Ala Ser Asp Asp Gly Asp 
385                 390                 395                 400 


Val Leu Asp Ser Phe Gln Xaa Ser Pro Ser Xaa Glu Ser Leu Lys Ser 
                405                 410                 415     


Xaa Ser Ser Asp Pro Gly Ser Arg Gln Ala Gly Arg Arg Arg Gly Gln 
            420                 425                 430         


Gln Gln Glu Xaa Glu Xaa Phe Tyr Leu Xaa Lys Leu Gln Glu Tyr Leu 
        435                 440                 445             


Ser Gly Arg Ser Ile Leu Ala Lys Leu Gln Ala Lys His Glu Lys Leu 
    450                 455                 460                 


Gln Glu Ala Leu Gln Arg Gly Asp Lys Glu Glu Gln Glu Val Ser Trp 
465                 470                 475                 480 


Xaa Gln Tyr Xaa Gln Arg Lys Phe Gln Lys Ser Arg Gln Pro Arg Pro 
                485                 490                 495     


Ser Ser Gln Tyr Asn Gln Arg Leu Phe Gly Gly Asp Met Glu Lys Phe 
            500                 505                 510         


Ile Gln Ser Ser Gly Gln Pro Val Pro Leu Val Val Glu Ser Cys Ile 
        515                 520                 525             


Arg Phe Ile Asn Leu Asn Gly Glu Asp Pro Leu Val Glu Gly Cys Xaa 
    530                 535                 540                 


Ala His Asp Leu Asp Ser Val Ala Gly Val Leu Lys Leu Tyr Phe Arg 
545                 550                 555                 560 


Ser Leu Glu Pro Pro Leu Phe Pro Pro Asp Leu Phe Gly Glu Leu Leu 
                565                 570                 575     


Ala Ser Ser Gly Xaa Pro Ser Trp Arg Ala Trp Gly Arg Xaa Met Ser 
            580                 585                 590         


Arg Ser Trp Lys Pro Arg Cys Pro His Arg Arg Met Xaa Trp Arg Gly 
        595                 600                 605             


Ser Trp Arg Leu Trp Pro Ala Leu Pro Xaa Arg Ala Ala Gln Pro Arg 
    610                 615                 620                 


Ser 
625 


<210> 2857
<211> 946
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(942)
<223> Selenocysteine

<400> 2857
Met Ala Ala His Gly Lys Leu Arg Arg Glu Arg Gly Leu Gln Ala Glu 
1               5                   10                  15      


Tyr Glu Xaa Gln Val Lys Glu Met Arg Trp Gln Leu Ser Glu Gln Leu 
            20                  25                  30          


Arg Cys Leu Glu Leu Gln Gly Glu Leu Arg Arg Glu Leu Leu Gln Glu 
        35                  40                  45              


Leu Ala Glu Phe Met Arg Arg Arg Ala Glu Val Glu Leu Glu Tyr Ser 
    50                  55                  60                  


Arg Gly Leu Glu Lys Leu Ala Glu Arg Phe Ser Ser Arg Gly Gly Arg 
65                  70                  75                  80  


Leu Gly Ser Ser Arg Glu His Gln Ser Phe Arg Lys Glu Pro Ser Leu 
                85                  90                  95      


Leu Ser Pro Leu His Cys Trp Ala Val Leu Leu Gln His Xaa Arg Gln 
            100                 105                 110         


Gln Ser Arg Glu Ser Ala Ala Leu Ser Glu Val Leu Ala Gly Pro Leu 
        115                 120                 125             


Ala Gln Arg Leu Ser His Ile Ala Glu Asp Val Gly Arg Leu Val Lys 
    130                 135                 140                 


Lys Ser Arg Asp Leu Glu Gln Gln Leu Gln Asp Glu Leu Leu Glu Val 
145                 150                 155                 160 


Val Ser Glu Leu Gln Xaa Ala Lys Lys Xaa Tyr Gln Ala Tyr His Met 
                165                 170                 175     


Glu Ser Val Asn Ala Glu Ala Lys Leu Arg Glu Ala Glu Arg Gln Glu 
            180                 185                 190         


Glu Lys Arg Ala Gly Arg Ser Val Pro Xaa Xaa Xaa Ala Gly Ala Xaa 
        195                 200                 205             


Glu Ala Gly Pro Leu Arg Lys Ser Ser Leu Lys Lys Gly Gly Arg Leu 
    210                 215                 220                 


Val Glu Lys Arg Gln Ala Lys Phe Met Glu His Lys Leu Lys Cys Xaa 
225                 230                 235                 240 


Lys Ala Arg Asn Glu Tyr Leu Leu Ser Leu Ala Ser Val Asn Ala Ala 
                245                 250                 255     


Val Ser Asn Tyr Tyr Leu His Asp Val Leu Asp Leu Met Asp Cys Cys 
            260                 265                 270         


Asp Xaa Gly Phe His Leu Ala Leu Gly Gln Val Leu Arg Ser Tyr Xaa 
        275                 280                 285             


Ala Ala Glu Ser Arg Xaa Gln Ala Ser Gln Val Gln Gly Leu Gly Ser 
    290                 295                 300                 


Leu Glu Glu Ala Val Glu Ala Leu Asp Pro Pro Gly Asp Lys Ala Lys 
305                 310                 315                 320 


Val Leu Glu Val His Ala Xaa Val Phe Cys Pro Pro Leu Arg Phe Asp 
                325                 330                 335     


Tyr His Pro His Asp Gly Asp Glu Val Ala Glu Ile Cys Val Glu Met 
            340                 345                 350         


Glu Leu Arg Asp Glu Ile Leu Pro Arg Ala Gln Asn Ile Gln Ser Arg 
        355                 360                 365             


Leu Asp Arg Gln Xaa Ile Glu Xaa Glu Glu Val Asn Lys Xaa Leu Lys 
    370                 375                 380                 


Ala Xaa Leu Gln Ala Leu Leu Glu Val Val Ala Ser Asp Asp Gly Asp 
385                 390                 395                 400 


Val Leu Asp Ser Phe Gln Xaa Ser Pro Ser Xaa Glu Ser Leu Lys Ser 
                405                 410                 415     


Xaa Ser Ser Asp Pro Gly Ser Arg Gln Ala Gly Arg Arg Arg Gly Gln 
            420                 425                 430         


Gln Gln Glu Xaa Glu Xaa Phe Tyr Leu Xaa Lys Leu Gln Glu Tyr Leu 
        435                 440                 445             


Ser Gly Arg Ser Ile Leu Ala Lys Leu Gln Ala Lys His Glu Lys Leu 
    450                 455                 460                 


Gln Glu Ala Leu Gln Arg Gly Asp Lys Glu Glu Gln Glu Val Ser Trp 
465                 470                 475                 480 


Xaa Gln Tyr Xaa Gln Arg Lys Phe Gln Lys Ser Arg Gln Pro Arg Pro 
                485                 490                 495     


Ser Ser Gln Tyr Asn Gln Arg Leu Phe Gly Gly Asp Met Glu Lys Phe 
            500                 505                 510         


Ile Gln Ser Ser Gly Gln Pro Val Pro Leu Val Val Glu Ser Cys Ile 
        515                 520                 525             


Arg Phe Ile Asn Leu Asn Gly Leu Gln His Glu Gly Ile Phe Arg Val 
    530                 535                 540                 


Ser Gly Ala Gln Leu Arg Val Ser Glu Ile Arg Asp Ala Phe Glu Arg 
545                 550                 555                 560 


Gly Glu Asp Pro Leu Val Glu Gly Cys Xaa Ala His Asp Leu Asp Ser 
                565                 570                 575     


Val Ala Gly Val Leu Lys Leu Tyr Phe Arg Ser Leu Glu Pro Pro Leu 
            580                 585                 590         


Phe Pro Pro Asp Leu Phe Gly Glu Leu Leu Ala Ser Ser Glu Leu Glu 
        595                 600                 605             


Ala Xaa Ala Glu Arg Val Glu His Val Ser Arg Leu Leu Trp Arg Leu 
    610                 615                 620                 


Pro Ala Pro Val Leu Val Val Leu Arg Tyr Leu Phe Xaa Phe Leu Asn 
625                 630                 635                 640 


His Leu Ala Gln Tyr Ser Asp Glu Asn Met Met Asp Pro Tyr Asn Leu 
                645                 650                 655     


Ala Val Cys Phe Gly Pro Xaa Leu Leu Pro Val Pro Ala Gly Gln Asp 
            660                 665                 670         


Pro Val Ala Leu Gln Gly Arg Val Asn Gln Leu Val Gln Xaa Leu Ile 
        675                 680                 685             


Val Gln Pro Asp Arg Val Phe Pro Pro Leu Xaa Ser Leu Pro Gly Pro 
    690                 695                 700                 


Val Tyr Glu Lys Cys Met Ala Pro Pro Ser Ala Ser Cys Leu Gly Asp 
705                 710                 715                 720 


Ala Gln Leu Glu Ser Leu Gly Ala Asp Asn Glu Pro Glu Leu Glu Ala 
                725                 730                 735     


Glu Met Pro Ala Gln Glu Asp Asp Leu Glu Gly Val Val Glu Ala Val 
            740                 745                 750         


Ala Cys Phe Ala Tyr Xaa Gly Arg Xaa Ala Gln Glu Leu Ser Phe Arg 
        755                 760                 765             


Arg Gly Asp Val Leu Arg Leu His Glu Arg Ala Ser Ser Asp Trp Trp 
    770                 775                 780                 


Arg Gly Glu His Asn Gly Met Arg Gly Leu Ile Pro His Lys Tyr Ile 
785                 790                 795                 800 


Xaa Leu Pro Ala Gly Xaa Glu Lys Gln Val Val Gly Ala Gly Leu Gln 
                805                 810                 815     


Xaa Ala Gly Glu Ser Gly Ser Ser Pro Glu Gly Leu Leu Ala Ser Glu 
            820                 825                 830         


Leu Val His Arg Pro Glu Pro Cys Xaa Ser Pro Glu Ala Met Gly Pro 
        835                 840                 845             


Ser Gly His Arg Arg Arg Cys Leu Val Pro Ala Ser Pro Glu Gln His 
    850                 855                 860                 


Val Glu Val Asp Lys Ala Val Ala Gln Asn Met Asp Ser Val Phe Lys 
865                 870                 875                 880 


Glu Leu Leu Gly Lys Xaa Ser Val Arg Gln Gly Leu Gly Pro Ala Ser 
                885                 890                 895     


Xaa Xaa Ser Pro Ser Pro Gly Pro Arg Ser Pro Lys Ala Pro Pro Ser 
            900                 905                 910         


Ser Arg Leu Gly Arg Asn Lys Gly Phe Ser Arg Gly Pro Gly Ala Pro 
        915                 920                 925             


Ala Ser Pro Ser Ala Ser His Pro Gln Gly Leu Asp Xaa Xaa Pro Lys 
    930                 935                 940                 


Pro His 
945     


<210> 2858
<211> 217
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 2858
Met Ala Ala His Gly Lys Leu Arg Arg Glu Arg Gly Leu Gln Ala Glu 
1               5                   10                  15      


Tyr Glu Xaa Gln Val Lys Glu Met Arg Trp Gln Leu Ser Glu Gln Leu 
            20                  25                  30          


Arg Cys Leu Glu Leu Gln Gly Glu Leu Arg Arg Glu Leu Leu Gln Glu 
        35                  40                  45              


Leu Ala Glu Phe Met Arg Arg Arg Ala Glu Val Glu Leu Glu Tyr Ser 
    50                  55                  60                  


Arg Gly Leu Glu Lys Leu Ala Glu Arg Phe Ser Ser Arg Gly Gly Arg 
65                  70                  75                  80  


Leu Gly Ser Ser Arg Glu His Gln Ser Phe Arg Lys Glu Pro Ser Leu 
                85                  90                  95      


Leu Ser Pro Leu His Cys Trp Ala Val Leu Leu Gln His Xaa Arg Gln 
            100                 105                 110         


Gln Ser Arg Glu Ser Ala Ala Leu Ser Glu Val Leu Ala Gly Pro Leu 
        115                 120                 125             


Ala Gln Arg Leu Ser His Ile Ala Glu Asp Val Gly Arg Leu Val Lys 
    130                 135                 140                 


Lys Ser Arg Asp Leu Glu Gln Gln Leu Gln Asp Glu Leu Leu Glu Val 
145                 150                 155                 160 


Val Ser Glu Leu Gln Xaa His His Leu Ala Leu Gly Leu Pro Ala Gly 
                165                 170                 175     


Gln Glu Asp Val Pro Gly Ile Ser His Gly Glu Arg Glu Cys Arg Gly 
            180                 185                 190         


Gln Ala Pro Gly Gly Arg Ala Ala Gly Gly Glu Ala Gly Arg Pro Glu 
        195                 200                 205             


Cys Pro His His His Arg Trp Cys His 
    210                 215         


<210> 2859
<211> 768
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(764)
<223> Selenocysteine

<400> 2859
Met Ala Ala His Gly Lys Leu Arg Arg Glu Arg Gly Leu Gln Ala Glu 
1               5                   10                  15      


Tyr Glu Xaa Gln Val Lys Glu Met Arg Trp Gln Leu Ser Glu Gln Leu 
            20                  25                  30          


Arg Cys Leu Glu Leu Gln Gly Glu Leu Arg Arg Glu Leu Leu Gln Glu 
        35                  40                  45              


Leu Ala Glu Phe Met Arg Arg Arg Ala Glu Val Glu Leu Glu Tyr Ser 
    50                  55                  60                  


Arg Gly Leu Glu Lys Leu Ala Glu Arg Phe Ser Ser Arg Gly Gly Arg 
65                  70                  75                  80  


Leu Gly Ser Ser Arg Glu His Gln Ser Phe Arg Lys Glu Pro Ser Leu 
                85                  90                  95      


Leu Ser Pro Leu His Cys Trp Ala Val Leu Leu Gln His Xaa Arg Gln 
            100                 105                 110         


Gln Ser Arg Glu Ser Ala Ala Leu Ser Glu Val Leu Ala Gly Pro Leu 
        115                 120                 125             


Ala Gln Arg Leu Ser His Ile Ala Glu Asp Val Gly Arg Leu Val Lys 
    130                 135                 140                 


Lys Ser Arg Asp Leu Glu Gln Gln Leu Gln Asp Glu Leu Leu Glu Val 
145                 150                 155                 160 


Val Ser Glu Leu Gln Xaa Val Ala Glu Ile Cys Val Glu Met Glu Leu 
                165                 170                 175     


Arg Asp Glu Ile Leu Pro Arg Ala Gln Asn Ile Gln Ser Arg Leu Asp 
            180                 185                 190         


Arg Gln Xaa Ile Glu Xaa Glu Glu Val Asn Lys Xaa Leu Lys Ala Xaa 
        195                 200                 205             


Leu Gln Ala Leu Leu Glu Val Val Ala Ser Asp Asp Gly Asp Val Leu 
    210                 215                 220                 


Asp Ser Phe Gln Xaa Ser Pro Ser Xaa Glu Ser Leu Lys Ser Xaa Ser 
225                 230                 235                 240 


Ser Asp Pro Gly Ser Arg Gln Ala Gly Arg Arg Arg Gly Gln Gln Gln 
                245                 250                 255     


Glu Xaa Glu Xaa Phe Tyr Leu Xaa Lys Leu Gln Glu Tyr Leu Ser Gly 
            260                 265                 270         


Arg Ser Ile Leu Ala Lys Leu Gln Ala Lys His Glu Lys Leu Gln Glu 
        275                 280                 285             


Ala Leu Gln Arg Gly Asp Lys Glu Glu Gln Glu Val Ser Trp Xaa Gln 
    290                 295                 300                 


Tyr Xaa Gln Arg Lys Phe Gln Lys Ser Arg Gln Pro Arg Pro Ser Ser 
305                 310                 315                 320 


Gln Tyr Asn Gln Arg Leu Phe Gly Gly Asp Met Glu Lys Phe Ile Gln 
                325                 330                 335     


Ser Ser Gly Gln Pro Val Pro Leu Val Val Glu Ser Cys Ile Arg Phe 
            340                 345                 350         


Ile Asn Leu Asn Gly Leu Gln His Glu Gly Ile Phe Arg Val Ser Gly 
        355                 360                 365             


Ala Gln Leu Arg Val Ser Glu Ile Arg Asp Ala Phe Glu Arg Gly Glu 
    370                 375                 380                 


Asp Pro Leu Val Glu Gly Cys Xaa Ala His Asp Leu Asp Ser Val Ala 
385                 390                 395                 400 


Gly Val Leu Lys Leu Tyr Phe Arg Ser Leu Glu Pro Pro Leu Phe Pro 
                405                 410                 415     


Pro Asp Leu Phe Gly Glu Leu Leu Ala Ser Ser Glu Leu Glu Ala Xaa 
            420                 425                 430         


Ala Glu Arg Val Glu His Val Ser Arg Leu Leu Trp Arg Leu Pro Ala 
        435                 440                 445             


Pro Val Leu Val Val Leu Arg Tyr Leu Phe Xaa Phe Leu Asn His Leu 
    450                 455                 460                 


Ala Gln Tyr Ser Asp Glu Asn Met Met Asp Pro Tyr Asn Leu Ala Val 
465                 470                 475                 480 


Cys Phe Gly Pro Xaa Leu Leu Pro Val Pro Ala Gly Gln Asp Pro Val 
                485                 490                 495     


Ala Leu Gln Gly Arg Val Asn Gln Leu Val Gln Xaa Leu Ile Val Gln 
            500                 505                 510         


Pro Asp Arg Val Phe Pro Pro Leu Xaa Ser Leu Pro Gly Pro Val Tyr 
        515                 520                 525             


Glu Lys Cys Met Ala Pro Pro Ser Ala Ser Cys Leu Gly Asp Ala Gln 
    530                 535                 540                 


Leu Glu Ser Leu Gly Ala Asp Asn Glu Pro Glu Leu Glu Ala Glu Met 
545                 550                 555                 560 


Pro Ala Gln Glu Asp Asp Leu Glu Gly Val Val Glu Ala Val Ala Cys 
                565                 570                 575     


Phe Ala Tyr Xaa Gly Arg Xaa Ala Gln Glu Leu Ser Phe Arg Arg Gly 
            580                 585                 590         


Asp Val Leu Arg Leu His Glu Arg Ala Ser Ser Asp Trp Trp Arg Gly 
        595                 600                 605             


Glu His Asn Gly Met Arg Gly Leu Ile Pro His Lys Tyr Ile Xaa Leu 
    610                 615                 620                 


Pro Ala Gly Xaa Glu Lys Gln Val Val Gly Ala Gly Leu Gln Xaa Ala 
625                 630                 635                 640 


Gly Glu Ser Gly Ser Ser Pro Glu Gly Leu Leu Ala Ser Glu Leu Val 
                645                 650                 655     


His Arg Pro Glu Pro Cys Xaa Ser Pro Glu Ala Met Gly Pro Ser Gly 
            660                 665                 670         


His Arg Arg Arg Cys Leu Val Pro Ala Ser Pro Glu Gln His Val Glu 
        675                 680                 685             


Val Asp Lys Ala Val Ala Gln Asn Met Asp Ser Val Phe Lys Glu Leu 
    690                 695                 700                 


Leu Gly Lys Xaa Ser Val Arg Gln Gly Leu Gly Pro Ala Ser Xaa Xaa 
705                 710                 715                 720 


Ser Pro Ser Pro Gly Pro Arg Ser Pro Lys Ala Pro Pro Ser Ser Arg 
                725                 730                 735     


Leu Gly Arg Asn Lys Gly Phe Ser Arg Gly Pro Gly Ala Pro Ala Ser 
            740                 745                 750         


Pro Ser Ala Ser His Pro Gln Gly Leu Asp Xaa Xaa Pro Lys Pro His 
        755                 760                 765             


<210> 2860
<211> 174
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<400> 2860
Met Arg Trp Gln Leu Ser Glu Gln Leu Arg Cys Leu Glu Leu Gln Gly 
1               5                   10                  15      


Glu Leu Arg Arg Glu Leu Leu Gln Glu Leu Ala Glu Phe Met Arg Arg 
            20                  25                  30          


Arg Ala Glu Val Glu Leu Glu Tyr Ser Arg Gly Leu Glu Lys Leu Ala 
        35                  40                  45              


Glu Arg Phe Ser Ser Arg Gly Gly Arg Leu Gly Ser Ser Arg Glu His 
    50                  55                  60                  


Gln Ser Phe Arg Lys Glu Pro Ser Leu Leu Ser Pro Leu His Cys Trp 
65                  70                  75                  80  


Ala Val Leu Leu Gln His Xaa Arg Gln Gln Ser Arg Glu Ser Ala Ala 
                85                  90                  95      


Leu Ser Glu Val Leu Ala Gly Pro Leu Ala Gln Arg Leu Ser His Ile 
            100                 105                 110         


Ala Glu Asp Val Gly Arg Leu Val Lys Lys Ser Arg Asp Leu Glu Gln 
        115                 120                 125             


Gln Leu Gln Asp Glu Leu Leu Glu Val Val Ser Glu Leu Gln Xaa Ala 
    130                 135                 140                 


Lys Lys Xaa Tyr Gln Ala Tyr His Met Glu Ser Val Asn Ala Glu Ala 
145                 150                 155                 160 


Lys Leu Arg Glu Ala Glu Arg Gln Glu Glu Lys Arg Ala Gly 
                165                 170                 


<210> 2861
<211> 177
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<400> 2861
Met Arg Trp Gln Leu Ser Glu Gln Leu Arg Cys Leu Glu Leu Gln Gly 
1               5                   10                  15      


Glu Leu Arg Arg Glu Leu Leu Gln Glu Leu Ala Glu Phe Met Arg Arg 
            20                  25                  30          


Arg Ala Glu Val Glu Leu Glu Tyr Ser Arg Gly Leu Glu Lys Leu Ala 
        35                  40                  45              


Glu Arg Phe Ser Ser Arg Gly Gly Arg Leu Gly Ser Ser Arg Glu His 
    50                  55                  60                  


Gln Ser Phe Arg Lys Glu Pro Ser Leu Leu Ser Pro Leu His Cys Trp 
65                  70                  75                  80  


Ala Val Leu Leu Gln His Xaa Arg Gln Gln Ser Arg Glu Ser Ala Ala 
                85                  90                  95      


Leu Ser Glu Val Leu Ala Gly Pro Leu Ala Gln Arg Leu Ser His Ile 
            100                 105                 110         


Ala Glu Asp Val Gly Arg Leu Val Lys Lys Ser Arg Asp Leu Glu Gln 
        115                 120                 125             


Gln Leu Gln Asp Glu Leu Leu Glu Val Val Ser Glu Leu Gln Xaa Ala 
    130                 135                 140                 


Lys Lys Xaa Tyr Gln Ala Tyr His Met Glu Ser Val Asn Ala Glu Ala 
145                 150                 155                 160 


Lys Leu Arg Glu Ala Glu Arg Gln Glu Glu Lys Arg Ala Gly Arg Ser 
                165                 170                 175     


Val 
    


<210> 2862
<211> 278
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<400> 2862
Met Arg Trp Gln Leu Ser Glu Gln Leu Arg Cys Leu Glu Leu Gln Gly 
1               5                   10                  15      


Glu Leu Arg Arg Glu Leu Leu Gln Glu Leu Ala Glu Phe Met Arg Arg 
            20                  25                  30          


Arg Ala Glu Val Glu Leu Glu Tyr Ser Arg Gly Leu Glu Lys Leu Ala 
        35                  40                  45              


Glu Arg Phe Ser Ser Arg Gly Gly Arg Leu Gly Ser Ser Arg Glu His 
    50                  55                  60                  


Gln Ser Phe Arg Lys Glu Pro Ser Leu Leu Ser Pro Leu His Cys Trp 
65                  70                  75                  80  


Ala Val Leu Leu Gln His Xaa Arg Gln Gln Ser Arg Glu Ser Ala Ala 
                85                  90                  95      


Leu Ser Glu Val Leu Ala Gly Pro Leu Ala Gln Arg Leu Ser His Ile 
            100                 105                 110         


Ala Glu Asp Val Gly Arg Leu Val Lys Lys Ser Arg Asp Leu Glu Gln 
        115                 120                 125             


Gln Leu Gln Asp Glu Leu Leu Glu Val Val Ser Glu Leu Gln Xaa Ala 
    130                 135                 140                 


Lys Lys Xaa Tyr Gln Ala Tyr His Met Glu Ser Val Asn Ala Glu Ala 
145                 150                 155                 160 


Lys Leu Arg Glu Ala Glu Arg Gln Glu Glu Lys Arg Ala Gly Arg Ser 
                165                 170                 175     


Val Pro Xaa Xaa Xaa Ala Gly Ala Xaa Glu Ala Gly Pro Leu Arg Lys 
            180                 185                 190         


Ser Ser Leu Lys Lys Gly Gly Arg Leu Val Glu Lys Arg Gln Ala Lys 
        195                 200                 205             


Phe Met Glu His Lys Leu Lys Cys Xaa Lys Ala Arg Asn Glu Tyr Leu 
    210                 215                 220                 


Leu Ser Leu Ala Ser Val Asn Ala Ala Val Ser Asn Tyr Tyr Leu His 
225                 230                 235                 240 


Asp Val Leu Asp Leu Met Asp Cys Cys Asp Xaa Gly Phe His Leu Ala 
                245                 250                 255     


Leu Gly Gln Val Leu Arg Ser Tyr Xaa Ala Ala Glu Ser Arg Xaa Gln 
            260                 265                 270         


Ala Ser Gln Val Gln Gly 
        275             


<210> 2863
<211> 317
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<400> 2863
Met Arg Trp Gln Leu Ser Glu Gln Leu Arg Cys Leu Glu Leu Gln Gly 
1               5                   10                  15      


Glu Leu Arg Arg Glu Leu Leu Gln Glu Leu Ala Glu Phe Met Arg Arg 
            20                  25                  30          


Arg Ala Glu Val Glu Leu Glu Tyr Ser Arg Gly Leu Glu Lys Leu Ala 
        35                  40                  45              


Glu Arg Phe Ser Ser Arg Gly Gly Arg Leu Gly Ser Ser Arg Glu His 
    50                  55                  60                  


Gln Ser Phe Arg Lys Glu Pro Ser Leu Leu Ser Pro Leu His Cys Trp 
65                  70                  75                  80  


Ala Val Leu Leu Gln His Xaa Arg Gln Gln Ser Arg Glu Ser Ala Ala 
                85                  90                  95      


Leu Ser Glu Val Leu Ala Gly Pro Leu Ala Gln Arg Leu Ser His Ile 
            100                 105                 110         


Ala Glu Asp Val Gly Arg Leu Val Lys Lys Ser Arg Asp Leu Glu Gln 
        115                 120                 125             


Gln Leu Gln Asp Glu Leu Leu Glu Val Val Ser Glu Leu Gln Xaa Ala 
    130                 135                 140                 


Lys Lys Xaa Tyr Gln Ala Tyr His Met Glu Ser Val Asn Ala Glu Ala 
145                 150                 155                 160 


Lys Leu Arg Glu Ala Glu Arg Gln Glu Glu Lys Arg Ala Gly Arg Ser 
                165                 170                 175     


Val Pro Xaa Xaa Xaa Ala Gly Ala Xaa Glu Ala Gly Pro Leu Arg Lys 
            180                 185                 190         


Ser Ser Leu Lys Lys Gly Gly Arg Leu Val Glu Lys Arg Gln Ala Lys 
        195                 200                 205             


Phe Met Glu His Lys Leu Lys Cys Xaa Lys Ala Arg Asn Glu Tyr Leu 
    210                 215                 220                 


Leu Ser Leu Ala Ser Val Asn Ala Ala Val Ser Asn Tyr Tyr Leu His 
225                 230                 235                 240 


Asp Val Leu Asp Leu Met Asp Cys Cys Asp Xaa Gly Phe His Leu Ala 
                245                 250                 255     


Leu Gly Gln Val Leu Arg Ser Tyr Xaa Ala Ala Glu Ser Arg Xaa Gln 
            260                 265                 270         


Ala Ser Gln Val Gln Gly Leu Gly Ser Leu Glu Glu Ala Val Glu Ala 
        275                 280                 285             


Leu Asp Pro Pro Gly Asp Lys Ala Lys Val Leu Glu Val His Ala Xaa 
    290                 295                 300                 


Val Phe Cys Pro Pro Leu Arg Phe Asp Tyr His Pro His 
305                 310                 315         


<210> 2864
<211> 294
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<400> 2864
Xaa Lys Phe Gln Lys Ser Arg Gln Pro Arg Pro Ser Ser Gln Tyr Asn 
1               5                   10                  15      


Gln Arg Leu Phe Gly Gly Asp Met Glu Lys Phe Ile Gln Ser Ser Gly 
            20                  25                  30          


Gln Pro Val Pro Leu Val Val Glu Ser Cys Ile Arg Phe Ile Asn Leu 
        35                  40                  45              


Asn Gly Glu Asp Pro Leu Val Glu Gly Cys Xaa Ala His Asp Leu Asp 
    50                  55                  60                  


Ser Val Ala Gly Val Leu Lys Leu Tyr Phe Arg Ser Leu Glu Pro Pro 
65                  70                  75                  80  


Leu Phe Pro Pro Asp Leu Phe Gly Glu Leu Leu Ala Ser Ser Glu Leu 
                85                  90                  95      


Glu Ala Xaa Ala Glu Arg Val Glu His Val Ser Arg Leu Leu Trp Arg 
            100                 105                 110         


Leu Pro Ala Pro Val Leu Val Val Leu Arg Tyr Leu Phe Xaa Phe Leu 
        115                 120                 125             


Asn His Leu Ala Gln Tyr Ser Asp Glu Asn Met Met Asp Pro Tyr Asn 
    130                 135                 140                 


Leu Ala Val Cys Phe Gly Pro Xaa Leu Leu Pro Val Pro Ala Gly Gln 
145                 150                 155                 160 


Asp Pro Val Ala Leu Gln Gly Arg Val Asn Gln Leu Val Gln Xaa Leu 
                165                 170                 175     


Ile Val Gln Pro Asp Arg Val Phe Pro Pro Leu Xaa Ser Leu Pro Gly 
            180                 185                 190         


Pro Val Tyr Glu Lys Cys Met Ala Pro Pro Ser Ala Ser Cys Leu Gly 
        195                 200                 205             


Asp Ala Gln Leu Glu Ser Leu Gly Ala Asp Asn Glu Pro Glu Leu Glu 
    210                 215                 220                 


Ala Glu Met Pro Ala Gln Glu Asp Asp Leu Glu Gly Val Val Glu Ala 
225                 230                 235                 240 


Val Ala Cys Phe Ala Tyr Xaa Gly Arg Xaa Ala Gln Glu Leu Ser Phe 
                245                 250                 255     


Arg Arg Gly Asp Val Leu Arg Leu His Glu Arg Ala Ser Ser Asp Trp 
            260                 265                 270         


Trp Arg Gly Glu His Asn Gly Met Arg Gly Leu Ile Pro His Lys Tyr 
        275                 280                 285             


Ile Xaa Leu Pro Ala Gly 
    290                 


<210> 2865
<211> 249
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<400> 2865
Xaa Leu Ala Pro Ser Xaa Gln Phe Pro Ala Pro Gly Met Gly Gly His 
1               5                   10                  15      


Pro Gly Gly Ala Gly Glu Asp Ala Gln Cys Pro Pro Ala Pro Cys Pro 
            20                  25                  30          


Pro Xaa Gly Leu Gln His Glu Gly Ile Phe Arg Val Ser Gly Ala Gln 
        35                  40                  45              


Leu Arg Val Ser Glu Ile Arg Asp Ala Phe Glu Arg Gly Glu Asp Pro 
    50                  55                  60                  


Leu Val Glu Gly Cys Xaa Ala His Asp Leu Asp Ser Val Ala Gly Val 
65                  70                  75                  80  


Leu Lys Leu Tyr Phe Arg Ser Leu Glu Pro Pro Leu Phe Pro Pro Asp 
                85                  90                  95      


Leu Phe Gly Glu Leu Leu Ala Ser Ser Glu Leu Glu Ala Xaa Ala Glu 
            100                 105                 110         


Arg Val Glu His Val Ser Arg Leu Leu Trp Arg Leu Pro Ala Pro Val 
        115                 120                 125             


Leu Val Val Leu Arg Tyr Leu Phe Xaa Phe Leu Asn Gln Asp Ala Gln 
    130                 135                 140                 


Leu Glu Ser Leu Gly Ala Asp Asn Glu Pro Glu Leu Glu Ala Glu Met 
145                 150                 155                 160 


Pro Ala Gln Glu Asp Asp Leu Glu Gly Val Val Glu Ala Val Ala Cys 
                165                 170                 175     


Phe Ala Tyr Xaa Gly Arg Xaa Ala Gln Glu Leu Ser Phe Arg Arg Gly 
            180                 185                 190         


Asp Val Leu Arg Leu His Glu Arg Ala Ser Ser Asp Trp Trp Arg Gly 
        195                 200                 205             


Glu His Asn Gly Met Arg Gly Leu Ile Pro His Lys Tyr Ile Xaa Leu 
    210                 215                 220                 


Pro Ala Gly Xaa Glu Lys Gln Val Val Gly Ala Gly Leu Gln Xaa Ala 
225                 230                 235                 240 


Gly Glu Ser Gly Ser Ser Pro Glu Gly 
                245                 


<210> 2866
<211> 196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<400> 2866
Xaa Ser His Ile Ala Glu Asp Val Gly Arg Leu Val Lys Lys Ala Lys 
1               5                   10                  15      


Lys Xaa Tyr Gln Ala Tyr His Met Glu Ser Val Asn Ala Glu Ala Lys 
            20                  25                  30          


Leu Arg Glu Ala Glu Arg Gln Glu Glu Lys Arg Ala Gly Arg Ser Val 
        35                  40                  45              


Pro Xaa Xaa Xaa Ala Gly Ala Xaa Glu Ala Gly Pro Leu Arg Lys Ser 
    50                  55                  60                  


Ser Leu Lys Lys Gly Gly Arg Leu Val Glu Lys Leu Trp Pro Pro Gln 
65                  70                  75                  80  


Arg Pro Val Ala Ala Ser Ser Cys Ala Pro Val Cys Trp Leu Gln Ala 
                85                  90                  95      


Gly Phe Leu Val His Pro Pro Trp Trp Gly Ala Met Cys Ala Pro Ser 
            100                 105                 110         


Xaa His Gln Arg Gln Ala Lys Phe Met Glu His Lys Leu Lys Cys Xaa 
        115                 120                 125             


Lys Ala Arg Asn Glu Tyr Leu Leu Ser Leu Ala Ser Val Asn Ala Ala 
    130                 135                 140                 


Val Ser Asn Tyr Tyr Leu His Asp Val Leu Asp Leu Met Asp Cys Cys 
145                 150                 155                 160 


Asp Xaa Gly Phe His Leu Ala Leu Gly Gln Val Leu Arg Ser Tyr Xaa 
                165                 170                 175     


Ala Ala Glu Ser Arg Xaa Gln Ala Ser Gln Val Gln Gly Leu Gly Ser 
            180                 185                 190         


Leu Glu Glu Ala 
        195     


<210> 2867
<211> 622
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<400> 2867
Met Asp Gln Leu Pro Gln Lys Asn Leu Leu Arg Leu His Pro Ala Gly 
1               5                   10                  15      


Ser Ala Gly Cys Ser Xaa Gly Val Glu Ser Ser Ser Met Asp Gly Phe 
            20                  25                  30          


Trp Met Glu Val Glu Gln Ile Gln Gln Arg Asp Glu Leu Arg Glu Glu 
        35                  40                  45              


Asp Ser Gly Gly Asn Glu Gly Gln Leu Pro Glu Glu Gly Glu Ala Glu 
    50                  55                  60                  


Ser Gln Trp Leu Gln Asp Xaa Gly Leu Ser Gly Leu Leu Gly Gly Leu 
65                  70                  75                  80  


Gly Leu Asp Gly Asp His Gln Glu Leu Leu Ser Xaa Leu Xaa Gln Xaa 
                85                  90                  95      


Gln Val Ala Ala Val Cys Arg Arg Leu Asp Ile Tyr Ala Arg Ser Val 
            100                 105                 110         


Arg Arg Gln His Lys Xaa Pro Val Arg Asp Val Arg Asp Val Phe Gly 
        115                 120                 125             


Val Phe Asn Ser Gly Lys Met Ser Ser Glu Asn Gly Asp Ser Gly Met 
    130                 135                 140                 


Lys Gly Ala Gln Leu Ser Ser Gly Ala Ser Lys Phe Pro Pro Ala Ala 
145                 150                 155                 160 


Glu Pro Gly Gly Leu Gln Glu Gln Ala Gly Arg Glu Glu Ala Phe Asn 
                165                 170                 175     


Met Asp Ser Ala Tyr Ser Glu Gln Ala Ala Val Leu Leu Gln Arg Ser 
            180                 185                 190         


Arg Pro Ser Arg Gly Gly Xaa Ser Ala Trp Gly Lys Cys Ser Leu Pro 
        195                 200                 205             


Lys Phe Xaa Val Pro Lys Gly Arg Leu Gly Val Xaa Arg Ile Gly Asp 
    210                 215                 220                 


Leu Ser Leu Gln Asp Met Arg Lys Val Pro Ser Leu Ala Leu Ile Glu 
225                 230                 235                 240 


Leu Xaa Ala Leu Cys Asp Ile Leu Gly Leu Asp Leu Lys Arg Ser Lys 
                245                 250                 255     


Ala Gly Lys Trp Lys Ala Ala Glu Xaa Arg Leu Phe Gly Val Pro Leu 
            260                 265                 270         


Asp Ser Leu Leu Glu Ala Asp His Lys Val Leu Pro Ser Xaa Gln Val 
        275                 280                 285             


Pro Leu Val Leu Gln Ala Leu Leu Ser Cys Leu Glu Lys Arg Gly Leu 
    290                 295                 300                 


Asp Met Glu Gly Ile Leu Arg Val Pro Gly Ser Gln Ala Arg Val Lys 
305                 310                 315                 320 


Gly Leu Glu Gln Lys Leu Glu Arg Asp Phe Tyr Ala Gly Leu Phe Ser 
                325                 330                 335     


Trp Asp Glu Val His His Asn Asp Ala Ser Asp Leu Leu Lys Arg Phe 
            340                 345                 350         


Ile Arg Lys Leu Pro Xaa Pro Leu Leu Xaa Ala Glu Tyr Leu Pro Ala 
        355                 360                 365             


Phe Ala Val Val Pro Asn Ile Pro Asn Leu Lys Gln Arg Leu Gln Val 
    370                 375                 380                 


Leu His Leu Leu Ile Leu Ile Leu Pro Glu Pro Asn Arg Asn Ala Leu 
385                 390                 395                 400 


Lys Ala Leu Leu Glu Phe Leu Arg Lys Val Val Ala Arg Glu Gln His 
                405                 410                 415     


Asn Lys Met Xaa Leu Arg Asn Val Ser Xaa Val Met Ala Pro Asn Leu 
            420                 425                 430         


Phe Leu His Gln Gly Arg Pro Pro Lys Leu Pro Lys Gly Lys Glu Lys 
        435                 440                 445             


Gln Leu Ala Glu Gly Ala Ala Glu Val Val Gln Ile Met Val His Tyr 
    450                 455                 460                 


Gln Asp Leu Leu Trp Xaa Val Ala Ser Phe Leu Val Ala Gln Val Arg 
465                 470                 475                 480 


Lys Leu Asn Asp Ser Ser Ser Arg Arg Pro Gln Leu Cys Asp Ala Gly 
                485                 490                 495     


Leu Lys Xaa Trp Leu Arg Arg Met His Ala Asp Arg Asp Lys Ala Gly 
            500                 505                 510         


Asp Gly Leu Glu Ala Xaa Pro Lys Val Ala Lys Ile Gln Val Val Trp 
        515                 520                 525             


Pro Ile Lys Asp Pro Leu Lys Val Pro Leu Xaa Pro Ser Xaa Lys Val 
    530                 535                 540                 


Ala His Val Leu Arg Gln Phe Xaa Glu His Leu Ser Pro Gly Ser Lys 
545                 550                 555                 560 


Gly Gln Glu Asp Ser Glu Asp Met Asp Ser Leu Leu Leu His His Arg 
                565                 570                 575     


Ser Met Glu Ser Ala Asn Ile Leu Leu Tyr Glu Val Gly Gly Asn Ile 
            580                 585                 590         


Asn Glu His Arg Leu Asp Pro Asp Ala Tyr Leu Leu Asp Leu Tyr Arg 
        595                 600                 605             


Ala Asn Pro His Gly Glu Trp Val Leu Lys Gln Asn Pro Xaa 
    610                 615                 620         


<210> 2868
<211> 592
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<400> 2868
Xaa Gly Glu Ala Glu Ser Gln Trp Leu Gln Asp Xaa Gly Leu Ser Gly 
1               5                   10                  15      


Leu Leu Gly Gly Leu Gly Leu Asp Gly Asp His Gln Glu Leu Leu Ser 
            20                  25                  30          


Xaa Leu Xaa Gln Xaa Gln Val Ala Ala Val Cys Arg Arg Leu Asp Ile 
        35                  40                  45              


Tyr Ala Arg Ser Val Arg Arg Gln His Lys Xaa Pro Val Arg Asp Val 
    50                  55                  60                  


Arg Asp Val Phe Gly Val Phe Asn Ser Gly Lys Met Ser Ser Glu Asn 
65                  70                  75                  80  


Gly Asp Ser Gly Met Lys Gly Ala Gln Leu Ser Ser Gly Ala Ser Lys 
                85                  90                  95      


Phe Pro Pro Ala Ala Glu Pro Gly Gly Leu Gln Glu Gln Ala Gly Arg 
            100                 105                 110         


Glu Glu Ala Phe Asn Met Asp Ser Ala Tyr Ser Glu Gln Ala Ala Val 
        115                 120                 125             


Leu Leu Gln Arg Ser Arg Pro Ser Arg Gly Gly Xaa Ser Ala Trp Gly 
    130                 135                 140                 


Lys Cys Ser Leu Pro Lys Phe Xaa Val Pro Lys Gly Arg Leu Gly Val 
145                 150                 155                 160 


Xaa Arg Ile Gly Asp Leu Ser Leu Gln Asp Met Arg Lys Val Pro Ser 
                165                 170                 175     


Leu Ala Leu Ile Glu Leu Xaa Ala Leu Cys Asp Ile Leu Gly Leu Asp 
            180                 185                 190         


Leu Lys Arg Ser Lys Ala Gly Lys Trp Lys Ala Ala Glu Xaa Arg Leu 
        195                 200                 205             


Phe Gly Val Pro Leu Asp Ser Leu Leu Glu Ala Asp His Lys Val Leu 
    210                 215                 220                 


Pro Ser Xaa Gln Val Pro Leu Val Leu Gln Ala Leu Leu Ser Cys Leu 
225                 230                 235                 240 


Glu Lys Arg Gly Leu Asp Met Glu Gly Ile Leu Arg Val Pro Gly Ser 
                245                 250                 255     


Gln Ala Arg Val Lys Gly Leu Glu Gln Lys Leu Glu Arg Asp Phe Tyr 
            260                 265                 270         


Ala Gly Leu Phe Ser Trp Asp Glu Val His His Asn Asp Ala Ser Asp 
        275                 280                 285             


Leu Leu Lys Arg Phe Ile Arg Lys Leu Pro Xaa Pro Leu Leu Xaa Ala 
    290                 295                 300                 


Glu Tyr Leu Pro Ala Phe Ala Val Val Pro Asn Ile Pro Asn Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Gln Val Leu His Leu Leu Ile Leu Ile Leu Pro Glu Pro 
                325                 330                 335     


Asn Arg Asn Ala Leu Lys Ala Leu Leu Glu Phe Leu Arg Lys Val Val 
            340                 345                 350         


Ala Arg Glu Gln His Asn Lys Met Xaa Leu Arg Asn Val Ser Xaa Val 
        355                 360                 365             


Met Ala Pro Asn Leu Phe Leu His Gln Gly Arg Pro Pro Lys Leu Pro 
    370                 375                 380                 


Lys Gly Lys Glu Lys Gln Leu Ala Glu Gly Ala Ala Glu Val Val Gln 
385                 390                 395                 400 


Ile Met Val His Tyr Gln Asp Leu Leu Trp Xaa Val Ala Ser Phe Leu 
                405                 410                 415     


Val Ala Gln Val Arg Lys Leu Asn Asp Ser Ser Ser Arg Arg Pro Gln 
            420                 425                 430         


Leu Cys Asp Ala Gly Leu Lys Xaa Trp Leu Arg Arg Met His Ala Asp 
        435                 440                 445             


Arg Asp Lys Ala Gly Asp Gly Leu Glu Ala Xaa Pro Lys Val Ala Lys 
    450                 455                 460                 


Ile Gln Val Val Trp Pro Ile Lys Asp Pro Leu Lys Val Pro Leu Xaa 
465                 470                 475                 480 


Pro Ser Xaa Lys Val Ala His Val Leu Arg Gln Phe Xaa Glu His Leu 
                485                 490                 495     


Ser Pro Gly Ser Lys Gly Gln Glu Asp Ser Glu Asp Met Asp Ser Leu 
            500                 505                 510         


Leu Leu His His Arg Ser Met Glu Ser Ala Asn Ile Leu Leu Tyr Glu 
        515                 520                 525             


Val Gly Gly Asn Ile Asn Glu His Arg Leu Asp Pro Asp Ala Tyr Leu 
    530                 535                 540                 


Leu Asp Leu Tyr Arg Ala Asn Pro His Gly Lys Ile Val Ser Lys Val 
545                 550                 555                 560 


Ala Leu Gln Cys Val Val Ala Ala Ala Pro Glu Xaa Lys Pro Gly Glu 
                565                 570                 575     


Leu Cys Asp Leu Gly Gln Ala Pro Cys Pro Leu Arg Ile Leu Ser Gly 
            580                 585                 590         


<210> 2869
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 2869
Xaa His Leu Ser Pro Gly Ser Lys Gly Gln Glu Asp Ser Glu Asp Met 
1               5                   10                  15      


Asp Ser Leu Leu Leu His His Arg Ser Met Glu Ser Ala Asn Ile Leu 
            20                  25                  30          


Leu Tyr Glu Val Gly Gly Asn Ile Asn Glu His Arg Leu Asp Pro Asp 
        35                  40                  45              


Ala Tyr Leu Leu Asp Leu Tyr Arg Ala Asn Pro His Val Gln Cys Ser 
    50                  55                  60                  


Val Gly Val Val Leu Pro Ala Ser 
65                  70          


<210> 2870
<211> 154
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<400> 2870
Xaa Xaa Val Ala Ser Phe Leu Val Ala Gln Val Arg Lys Leu Asn Asp 
1               5                   10                  15      


Ser Ser Ser Arg Arg Pro Gln Leu Cys Asp Ala Gly Leu Lys Xaa Trp 
            20                  25                  30          


Leu Arg Arg Met His Ala Asp Arg Asp Lys Ala Gly Asp Gly Leu Glu 
        35                  40                  45              


Ala Xaa Pro Lys Val Ala Lys Ile Gln Val Val Trp Pro Ile Lys Asp 
    50                  55                  60                  


Pro Leu Lys Val Pro Leu Xaa Pro Ser Xaa Lys Val Ala His Val Leu 
65                  70                  75                  80  


Arg Gln Phe Xaa Glu His Leu Ser Pro Gly Ser Lys Gly Gln Glu Asp 
                85                  90                  95      


Ser Glu Asp Met Asp Ser Leu Leu Leu His His Arg Ser Met Glu Ser 
            100                 105                 110         


Ala Asn Ile Leu Leu Tyr Glu Val Gly Gly Asn Ile Asn Glu His Arg 
        115                 120                 125             


Leu Asp Pro Asp Ala Tyr Leu Leu Asp Leu Tyr Arg Ala Asn Pro His 
    130                 135                 140                 


Gly Glu Trp Val Leu Lys Gln Asn Pro Xaa 
145                 150                 


<210> 2871
<211> 230
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<400> 2871
Leu Glu Lys His Leu Asn Leu Ser Ala Lys Lys Lys Glu Ser His Leu 
1               5                   10                  15      


Gln Glu Ala Asp Xaa Gln Ile Asp Arg Glu His Gln Asn Phe Tyr Glu 
            20                  25                  30          


Ala Ser Leu Glu Tyr Val Phe Lys Ile Gln Glu Val Gln Glu Lys Lys 
        35                  40                  45              


Lys Phe Glu Phe Val Glu Pro Leu Leu Ser Phe Leu Gln Gly Leu Phe 
    50                  55                  60                  


Xaa Phe Tyr His Glu Gly Tyr Glu Leu Ala Gln Glu Phe Ala Pro Tyr 
65                  70                  75                  80  


Lys Gln Gln Leu Gln Phe Asn Leu Gln Asn Xaa Arg Asn Asn Phe Glu 
                85                  90                  95      


Ser Xaa Arg Gln Glu Val Glu Arg Leu Met Gln Arg Met Lys Ser Ala 
            100                 105                 110         


Asn Gln Asp Tyr Arg Pro Pro Ser Gln Trp Xaa Met Glu Gly Tyr Leu 
        115                 120                 125             


Tyr Val Gln Glu Lys Arg Pro Leu Gly Phe Xaa Trp Ile Lys His Tyr 
    130                 135                 140                 


Cys Xaa Tyr Asp Lys Gly Ser Lys Xaa Phe Xaa Met Ser Val Ser Glu 
145                 150                 155                 160 


Met Lys Ser Ser Gly Lys Met Asn Gly Leu Val Xaa Ser Ser Pro Glu 
                165                 170                 175     


Met Phe Lys Leu Lys Ser Cys Ile Arg Arg Lys Xaa Asp Ser Ile Asp 
            180                 185                 190         


Lys Arg Phe Cys Phe Asp Ile Glu Val Val Glu Arg His Gly Ile Ile 
        195                 200                 205             


Xaa Leu Gln Ala Phe Ser Glu Ala Asn Arg Lys Leu Trp Leu Glu Ala 
    210                 215                 220                 


Met Asp Gly Lys Glu Pro 
225                 230 


<210> 2872
<211> 840
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<400> 2872
Met Gly Leu Pro Xaa Leu Glu Phe Ser Asp Ser Tyr Leu Asp Ser Pro 
1               5                   10                  15      


Asp Phe Arg Glu Arg Leu Gln Cys His Glu Ile Glu Leu Glu Arg Xaa 
            20                  25                  30          


Asn Lys Phe Ile Lys Glu Leu Ile Lys Asp Gly Ser Leu Leu Ile Gly 
        35                  40                  45              


Ala Leu Arg Asn Leu Ser Met Ala Val Gln Lys Phe Ser Gln Ser Leu 
    50                  55                  60                  


Gln Asp Phe Gln Phe Glu Cys Ile Gly Asp Ala Glu Xaa Asp Asp Glu 
65                  70                  75                  80  


Ile Ser Ile Ala Gln Ser Leu Lys Glu Phe Ala Arg Leu Leu Ile Ala 
                85                  90                  95      


Val Glu Glu Glu Arg Arg Arg Leu Ile Gln Asn Ala Asn Asp Val Leu 
            100                 105                 110         


Ile Ala Pro Leu Glu Lys Phe Arg Lys Glu Gln Ile Gly Ala Ala Lys 
        115                 120                 125             


Ala Asp Xaa Gln Ile Asp Arg Glu His Gln Asn Phe Tyr Glu Ala Ser 
    130                 135                 140                 


Leu Glu Tyr Val Phe Lys Ile Gln Glu Val Gln Glu Lys Lys Lys Phe 
145                 150                 155                 160 


Glu Phe Val Glu Pro Leu Leu Ser Phe Leu Gln Gly Leu Phe Xaa Phe 
                165                 170                 175     


Tyr His Glu Gly Tyr Glu Leu Ala Gln Glu Phe Ala Pro Tyr Lys Gln 
            180                 185                 190         


Gln Leu Gln Phe Asn Leu Gln Asn Xaa Arg Asn Asn Phe Glu Ser Xaa 
        195                 200                 205             


Arg Gln Glu Val Glu Arg Leu Met Gln Arg Met Lys Ser Ala Asn Gln 
    210                 215                 220                 


Asp Tyr Arg Pro Pro Ser Gln Trp Xaa Met Glu Gly Tyr Leu Tyr Val 
225                 230                 235                 240 


Gln Glu Lys Arg Pro Leu Gly Phe Xaa Trp Ile Lys His Tyr Cys Xaa 
                245                 250                 255     


Tyr Asp Lys Gly Ser Lys Xaa Phe Xaa Met Ser Val Ser Glu Met Lys 
            260                 265                 270         


Ser Ser Gly Lys Met Asn Gly Leu Val Xaa Ser Ser Pro Glu Met Phe 
        275                 280                 285             


Lys Leu Lys Ser Cys Ile Arg Arg Lys Xaa Asp Ser Ile Asp Lys Arg 
    290                 295                 300                 


Phe Cys Phe Asp Ile Glu Val Val Glu Arg His Gly Ile Ile Xaa Leu 
305                 310                 315                 320 


Gln Ala Phe Ser Glu Ala Asn Arg Lys Leu Trp Leu Glu Ala Met Asp 
                325                 330                 335     


Gly Lys Glu Pro Ile Tyr Xaa Leu Pro Ala Ile Ile Ser Lys Lys Glu 
            340                 345                 350         


Glu Met Tyr Leu Asn Glu Ala Gly Phe Asn Phe Val Arg Lys Cys Ile 
        355                 360                 365             


Gln Ala Val Glu Xaa Arg Gly Ile Xaa Ile Leu Gly Leu Tyr Arg Ile 
    370                 375                 380                 


Gly Gly Val Asn Ser Lys Val Gln Lys Leu Met Asn Xaa Xaa Phe Ser 
385                 390                 395                 400 


Pro Lys Ser Pro Pro Asp Ile Asp Ile Asp Ile Glu Leu Trp Asp Asn 
                405                 410                 415     


Lys Xaa Ile Xaa Ser Gly Leu Lys Asn Tyr Leu Arg Cys Leu Ala Glu 
            420                 425                 430         


Pro Leu Met Xaa Tyr Lys Leu His Lys Asp Phe Ile Ile Ala Val Lys 
        435                 440                 445             


Ser Asp Asp Gln Asn Tyr Arg Val Glu Ala Val His Ala Leu Val His 
    450                 455                 460                 


Lys Leu Pro Glu Lys Asn Arg Glu Met Leu Asp Ile Leu Ile Lys His 
465                 470                 475                 480 


Leu Val Lys Val Ser Leu His Ser Gln Gln Asn Leu Met Xaa Val Ser 
                485                 490                 495     


Asn Leu Gly Val Ile Phe Gly Pro Xaa Leu Met Arg Ala Gln Glu Glu 
            500                 505                 510         


Xaa Val Ala Ala Met Met Asn Ile Lys Phe Gln Asn Ile Val Val Glu 
        515                 520                 525             


Ile Leu Ile Glu His Tyr Glu Lys Ile Phe His Xaa Ala Pro Asp Pro 
    530                 535                 540                 


Ser Ile Pro Leu Pro Gln Pro Gln Ser Arg Ser Gly Ser Arg Arg Xaa 
545                 550                 555                 560 


Arg Ala Ile Cys Leu Ser Xaa Gly Ser Arg Lys Pro Arg Gly Arg Tyr 
                565                 570                 575     


Xaa Pro Cys Leu Ala Glu Pro Asp Ser Asp Ser Tyr Ser Ser Ser Pro 
            580                 585                 590         


Asp Ser Xaa Pro Met Gly Ser Ile Glu Ser Leu Ser Ser His Ser Ser 
        595                 600                 605             


Glu Gln Asn Ser Xaa Xaa Lys Ser Ala Ser Cys Gln Pro Arg Glu Lys 
    610                 615                 620                 


Ser Gly Gly Ile Pro Trp Ile Ala Xaa Pro Ser Ser Ser Asn Gly Gln 
625                 630                 635                 640 


Lys Ser Leu Gly Leu Trp Xaa Xaa Ser Pro Glu Ser Ser Ser Arg Glu 
                645                 650                 655     


Asp Ala Xaa Lys Xaa Asp Ala Glu Ser Asp Cys Gln Ser Val Ala Ser 
            660                 665                 670         


Val Xaa Ser Pro Gly Asp Val Ser Pro Pro Ile Asp Leu Val Lys Lys 
        675                 680                 685             


Glu Pro Tyr Gly Leu Ser Gly Leu Lys Arg Ala Ser Ala Ser Ser Leu 
    690                 695                 700                 


Arg Ser Ile Ser Ala Ala Glu Gly Asn Lys Ser Tyr Ser Gly Ser Ile 
705                 710                 715                 720 


Gln Ser Leu Xaa Ser Val Gly Ser Lys Glu Xaa Pro Lys Ala Ser Pro 
                725                 730                 735     


Asn Pro Asp Leu Pro Pro Lys Met Cys Arg Arg Leu Arg Leu Asp Xaa 
            740                 745                 750         


Ala Ser Ser Asn Gly Tyr Gln Arg Pro Gly Ser Val Val Ala Ala Lys 
        755                 760                 765             


Ala Gln Leu Phe Glu Asn Val Gly Ser Pro Lys Pro Val Ser Ser Gly 
    770                 775                 780                 


Arg Gln Ala Lys Ala Met Tyr Ser Cys Lys Ala Glu His Ser His Glu 
785                 790                 795                 800 


Leu Ser Phe Pro Gln Gly Ala Ile Phe Ser Asn Val Tyr Pro Ser Val 
                805                 810                 815     


Glu Pro Gly Trp Leu Lys Ala Xaa Tyr Glu Gly Lys Xaa Gly Leu Val 
            820                 825                 830         


Pro Glu Asn Tyr Val Val Phe Leu 
        835                 840 


<210> 2873
<211> 874
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<400> 2873
Met Gly Leu Pro Xaa Leu Glu Phe Ser Asp Ser Tyr Leu Asp Ser Pro 
1               5                   10                  15      


Asp Phe Arg Glu Arg Leu Gln Cys His Glu Ile Glu Leu Glu Arg Xaa 
            20                  25                  30          


Asn Lys Phe Ile Lys Glu Leu Ile Lys Asp Gly Ser Leu Leu Ile Gly 
        35                  40                  45              


Ala Leu Arg Asn Leu Ser Met Ala Val Gln Lys Phe Ser Gln Ser Leu 
    50                  55                  60                  


Gln Asp Phe Gln Phe Glu Cys Ile Gly Asp Ala Glu Xaa Asp Asp Glu 
65                  70                  75                  80  


Ile Ser Ile Ala Gln Ser Leu Lys Glu Phe Ala Arg Leu Leu Ile Ala 
                85                  90                  95      


Val Glu Glu Glu Arg Arg Arg Leu Ile Gln Asn Ala Asn Asp Val Leu 
            100                 105                 110         


Ile Ala Pro Leu Glu Lys Phe Arg Lys Glu Gln Ile Gly Ala Ala Lys 
        115                 120                 125             


Asp Gly Lys Lys Lys Phe Asp Lys Glu Ser Glu Lys Tyr Tyr Ser Ile 
    130                 135                 140                 


Leu Glu Lys His Leu Asn Leu Ser Ala Lys Lys Lys Glu Ser His Leu 
145                 150                 155                 160 


Gln Glu Ala Asp Xaa Gln Ile Asp Arg Glu His Gln Asn Phe Tyr Glu 
                165                 170                 175     


Ala Ser Leu Glu Tyr Val Phe Lys Ile Gln Glu Val Gln Glu Lys Lys 
            180                 185                 190         


Lys Phe Glu Phe Val Glu Pro Leu Leu Ser Phe Leu Gln Gly Leu Phe 
        195                 200                 205             


Xaa Phe Tyr His Glu Gly Tyr Glu Leu Ala Gln Glu Phe Ala Pro Tyr 
    210                 215                 220                 


Lys Gln Gln Leu Gln Phe Asn Leu Gln Asn Xaa Arg Asn Asn Phe Glu 
225                 230                 235                 240 


Ser Xaa Arg Gln Glu Val Glu Arg Leu Met Gln Arg Met Lys Ser Ala 
                245                 250                 255     


Asn Gln Asp Tyr Arg Pro Pro Ser Gln Trp Xaa Met Glu Gly Tyr Leu 
            260                 265                 270         


Tyr Val Gln Glu Lys Arg Pro Leu Gly Phe Xaa Trp Ile Lys His Tyr 
        275                 280                 285             


Cys Xaa Tyr Asp Lys Gly Ser Lys Xaa Phe Xaa Met Ser Val Ser Glu 
    290                 295                 300                 


Met Lys Ser Ser Gly Lys Met Asn Gly Leu Val Xaa Ser Ser Pro Glu 
305                 310                 315                 320 


Met Phe Lys Leu Lys Ser Cys Ile Arg Arg Lys Xaa Asp Ser Ile Asp 
                325                 330                 335     


Lys Arg Phe Cys Phe Asp Ile Glu Val Val Glu Arg His Gly Ile Ile 
            340                 345                 350         


Xaa Leu Gln Ala Phe Ser Glu Ala Asn Arg Lys Leu Trp Leu Glu Ala 
        355                 360                 365             


Met Asp Gly Lys Glu Pro Ile Tyr Xaa Leu Pro Ala Ile Ile Ser Lys 
    370                 375                 380                 


Lys Glu Glu Met Tyr Leu Asn Glu Ala Gly Phe Asn Phe Val Arg Lys 
385                 390                 395                 400 


Cys Ile Gln Ala Val Glu Xaa Arg Gly Ile Xaa Ile Leu Gly Leu Tyr 
                405                 410                 415     


Arg Ile Gly Gly Val Asn Ser Lys Val Gln Lys Leu Met Asn Xaa Xaa 
            420                 425                 430         


Phe Ser Pro Lys Ser Pro Pro Asp Ile Asp Ile Asp Ile Glu Leu Trp 
        435                 440                 445             


Asp Asn Lys Xaa Ile Xaa Ser Gly Leu Lys Asn Tyr Leu Arg Cys Leu 
    450                 455                 460                 


Ala Glu Pro Leu Met Xaa Tyr Lys Leu His Lys Asp Phe Ile Ile Ala 
465                 470                 475                 480 


Val Lys Ser Asp Asp Gln Asn Tyr Arg Val Glu Ala Val His Ala Leu 
                485                 490                 495     


Val His Lys Leu Pro Glu Lys Asn Arg Glu Met Leu Asp Ile Leu Ile 
            500                 505                 510         


Lys His Leu Val Lys Val Ser Leu His Ser Gln Gln Asn Leu Met Xaa 
        515                 520                 525             


Val Ser Asn Leu Gly Val Ile Phe Gly Pro Xaa Leu Met Arg Ala Gln 
    530                 535                 540                 


Glu Glu Xaa Val Ala Ala Met Met Asn Ile Lys Phe Gln Asn Ile Val 
545                 550                 555                 560 


Val Glu Ile Leu Ile Glu His Tyr Glu Lys Ile Phe His Xaa Ala Pro 
                565                 570                 575     


Asp Pro Ser Ile Pro Leu Pro Gln Pro Gln Ser Arg Ser Gly Ser Arg 
            580                 585                 590         


Arg Xaa Arg Ala Ile Cys Leu Ser Xaa Gly Ser Arg Lys Pro Arg Gly 
        595                 600                 605             


Arg Tyr Xaa Pro Cys Leu Ala Glu Pro Asp Ser Asp Ser Tyr Ser Ser 
    610                 615                 620                 


Ser Pro Asp Ser Xaa Pro Met Gly Ser Ile Glu Ser Leu Ser Ser His 
625                 630                 635                 640 


Ser Ser Glu Gln Asn Ser Xaa Xaa Lys Ser Ala Ser Cys Gln Pro Arg 
                645                 650                 655     


Glu Lys Ser Gly Gly Ile Pro Trp Ile Ala Xaa Pro Ser Ser Ser Asn 
            660                 665                 670         


Gly Gln Lys Ser Leu Gly Leu Trp Xaa Xaa Ser Pro Glu Ser Ser Ser 
        675                 680                 685             


Arg Glu Asp Ala Xaa Lys Xaa Asp Ala Glu Ser Asp Cys Gln Ser Val 
    690                 695                 700                 


Ala Ser Val Xaa Ser Pro Gly Asp Val Ser Pro Pro Ile Asp Leu Val 
705                 710                 715                 720 


Lys Lys Glu Pro Tyr Gly Leu Ser Gly Leu Lys Arg Ala Ser Ala Ser 
                725                 730                 735     


Ser Leu Arg Ser Ile Ser Ala Ala Glu Gly Asn Lys Ser Tyr Ser Gly 
            740                 745                 750         


Ser Ile Gln Ser Leu Xaa Ser Val Gly Ser Lys Glu Xaa Pro Lys Ala 
        755                 760                 765             


Ser Pro Asn Pro Asp Leu Pro Pro Lys Met Cys Arg Arg Leu Arg Leu 
    770                 775                 780                 


Asp Xaa Ala Ser Ser Asn Gly Tyr Gln Arg Pro Gly Ser Val Val Ala 
785                 790                 795                 800 


Ala Lys Ala Gln Leu Phe Glu Asn Val Gly Ser Pro Lys Pro Val Ser 
                805                 810                 815     


Ser Gly Arg Gln Ala Lys Ala Met Tyr Ser Cys Lys Ala Glu His Ser 
            820                 825                 830         


His Glu Leu Ser Phe Pro Gln Gly Ala Ile Phe Ser Asn Val Tyr Pro 
        835                 840                 845             


Ser Val Glu Pro Gly Trp Leu Lys Ala Xaa Tyr Glu Gly Lys Xaa Gly 
    850                 855                 860                 


Leu Val Pro Glu Asn Tyr Val Val Phe Leu 
865                 870                 


<210> 2874
<211> 443
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<400> 2874
Xaa Xaa Pro Asn Ala Ile Ser Leu Leu Phe Ser Val Tyr Leu Asn Glu 
1               5                   10                  15      


Ala Gly Phe Asn Phe Val Arg Lys Cys Ile Gln Ala Val Glu Xaa Arg 
            20                  25                  30          


Gly Ile Xaa Ile Leu Gly Leu Tyr Arg Ile Gly Gly Val Asn Ser Lys 
        35                  40                  45              


Val Gln Lys Leu Met Asn Xaa Xaa Phe Ser Pro Lys Ser Pro Pro Asp 
    50                  55                  60                  


Ile Asp Ile Asp Ile Glu Leu Trp Asp Asn Lys Xaa Ile Xaa Ser Gly 
65                  70                  75                  80  


Leu Lys Asn Tyr Leu Arg Cys Leu Ala Glu Pro Leu Met Xaa Tyr Lys 
                85                  90                  95      


Leu His Lys Asp Phe Ile Ile Ala Val Lys Ser Asp Asp Gln Asn Tyr 
            100                 105                 110         


Arg Val Glu Ala Val His Ala Leu Val His Lys Leu Pro Glu Lys Asn 
        115                 120                 125             


Arg Glu Met Leu Asp Ile Leu Ile Lys His Leu Val Lys Val Ser Leu 
    130                 135                 140                 


His Ser Gln Gln Asn Leu Met Xaa Val Ser Asn Leu Gly Val Ile Phe 
145                 150                 155                 160 


Gly Pro Xaa Leu Met Arg Ala Gln Glu Glu Xaa Val Ala Ala Met Met 
                165                 170                 175     


Asn Ile Lys Phe Gln Asn Ile Val Val Glu Ile Leu Ile Glu His Tyr 
            180                 185                 190         


Glu Lys Ile Phe His Xaa Ala Pro Asp Pro Ser Ile Pro Leu Pro Gln 
        195                 200                 205             


Pro Gln Ser Arg Ser Gly Ser Arg Arg Xaa Arg Ala Ile Cys Leu Ser 
    210                 215                 220                 


Xaa Gly Ser Arg Lys Pro Arg Gly Arg Tyr Xaa Pro Cys Leu Ala Glu 
225                 230                 235                 240 


Pro Asp Ser Asp Ser Tyr Ser Ser Ser Pro Asp Ser Xaa Pro Met Gly 
                245                 250                 255     


Ser Ile Glu Ser Leu Ser Ser His Ser Ser Glu Gln Asn Ser Xaa Xaa 
            260                 265                 270         


Lys Ser Ala Ser Cys Gln Pro Arg Glu Lys Ser Gly Gly Ile Pro Trp 
        275                 280                 285             


Ile Ala Xaa Pro Ser Ser Ser Asn Gly Gln Lys Ser Leu Gly Leu Trp 
    290                 295                 300                 


Xaa Xaa Ser Pro Glu Ser Ser Ser Arg Glu Asp Ala Xaa Lys Xaa Asp 
305                 310                 315                 320 


Ala Glu Ser Asp Cys Gln Ser Val Ala Ser Val Xaa Ser Pro Gly Asp 
                325                 330                 335     


Val Ser Pro Pro Ile Asp Leu Val Lys Lys Glu Pro Tyr Gly Leu Ser 
            340                 345                 350         


Gly Leu Lys Arg Ala Ser Ala Ser Ser Leu Arg Ser Ile Ser Ala Ala 
        355                 360                 365             


Glu Gly Asn Lys Ser Tyr Ser Gly Ser Ile Gln Ser Leu Xaa Ser Val 
    370                 375                 380                 


Gly Ser Lys Glu Xaa Pro Lys Ala Ser Pro Asn Pro Asp Leu Pro Pro 
385                 390                 395                 400 


Lys Met Cys Arg Arg Leu Arg Leu Asp Xaa Ala Ser Ser Asn Gly Tyr 
                405                 410                 415     


Gln Arg Pro Gly Ser Val Val Ala Ala Lys Ala Gln Leu Phe Glu Asn 
            420                 425                 430         


Val Gly Ser Pro Lys Pro Val Ser Ser Gly Arg 
        435                 440             


<210> 2875
<211> 178
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(175)
<223> Selenocysteine

<400> 2875
Met Lys Lys Gln Phe Asn Arg Met Arg Gln Leu Ala Asn Gln Xaa Val 
1               5                   10                  15      


Gly Arg Ala Glu Lys Xaa Glu Val Leu Ser Glu Asp Leu Leu Gln Val 
            20                  25                  30          


Glu Lys Arg Leu Glu Leu Val Lys Gln Val Ser His Ser Xaa His Lys 
        35                  40                  45              


Lys Leu Xaa Ala Cys Leu Gln Gly Gln Gln Gly Ala Glu Ala Asp Lys 
    50                  55                  60                  


Arg Ser Lys Lys Leu Pro Leu Xaa Xaa Leu Ala Gln Cys Leu Met Glu 
65                  70                  75                  80  


Gly Ser Ala Ile Leu Gly Asp Asp Xaa Leu Leu Gly Lys Met Leu Lys 
                85                  90                  95      


Leu Cys Gly Glu Xaa Glu Asp Lys Leu Ala Gln Glu Leu Ile His Phe 
            100                 105                 110         


Glu Leu Gln Val Glu Arg Asp Val Ile Glu Pro Leu Phe Leu Leu Ala 
        115                 120                 125             


Glu Val Glu Ile Pro Asn Ile Gln Lys Gln Arg Lys His Leu Ala Lys 
    130                 135                 140                 


Leu Val Leu Asp Met Asp Ser Ser Arg Xaa Arg Xaa Ser Ser Gln Leu 
145                 150                 155                 160 


Ile Cys Xaa Val Leu Trp Pro Lys Lys Leu Xaa Met Gln Xaa Xaa Phe 
                165                 170                 175     


Lys Arg 
        


<210> 2876
<211> 591
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<400> 2876
Met Lys Lys Gln Phe Asn Arg Met Arg Gln Leu Ala Asn Gln Xaa Val 
1               5                   10                  15      


Gly Arg Ala Glu Lys Xaa Glu Val Leu Ser Glu Asp Leu Leu Gln Val 
            20                  25                  30          


Glu Lys Arg Leu Glu Leu Val Lys Gln Val Ser His Ser Xaa His Lys 
        35                  40                  45              


Lys Leu Xaa Ala Cys Leu Gln Gly Gln Gln Gly Ala Glu Ala Asp Lys 
    50                  55                  60                  


Arg Ser Lys Lys Leu Pro Leu Xaa Xaa Leu Ala Gln Cys Leu Met Glu 
65                  70                  75                  80  


Gly Ser Ala Ile Leu Gly Asp Asp Xaa Leu Leu Gly Lys Met Leu Lys 
                85                  90                  95      


Leu Cys Gly Glu Xaa Glu Asp Lys Leu Ala Gln Glu Leu Ile His Phe 
            100                 105                 110         


Glu Leu Gln Val Glu Arg Asp Val Ile Glu Pro Leu Phe Leu Leu Ala 
        115                 120                 125             


Glu Val Glu Ile Pro Asn Ile Gln Lys Gln Arg Lys His Leu Ala Lys 
    130                 135                 140                 


Leu Val Leu Asp Met Asp Ser Ser Arg Xaa Arg Trp Gln Gln Xaa Ser 
145                 150                 155                 160 


Lys Ser Ser Gly Leu Ser Ser Ser Leu Gln Pro Ala Gly Ala Lys Ala 
                165                 170                 175     


Asp Ala Leu Arg Glu Glu Met Glu Glu Ala Ala Asn Arg Val Glu Ile 
            180                 185                 190         


Cys Arg Asp Gln Leu Ser Ala Asp Met Tyr Ser Phe Val Ala Lys Glu 
        195                 200                 205             


Ile Asp Tyr Ala Asn Tyr Phe Gln Xaa Leu Ile Glu Val Gln Ala Glu 
    210                 215                 220                 


Tyr His Arg Lys Ser Leu Xaa Leu Leu Gln Ala Val Leu Pro Gln Ile 
225                 230                 235                 240 


Lys Ala Gln Gln Glu Ala Trp Val Glu Lys Pro Ser Phe Gly Lys Pro 
                245                 250                 255     


Leu Glu Glu His Leu Xaa Ile Ser Gly Arg Glu Ile Ala Phe Pro Ile 
            260                 265                 270         


Glu Ala Cys Val Xaa Met Leu Leu Glu Cys Gly Met Gln Glu Glu Gly 
        275                 280                 285             


Leu Phe Arg Val Ala Pro Ser Ala Ser Lys Leu Lys Lys Leu Lys Ala 
    290                 295                 300                 


Ala Leu Asp Cys Cys Val Val Asp Val Gln Glu Tyr Ser Ala Asp Pro 
305                 310                 315                 320 


His Ala Ile Ala Gly Ala Leu Lys Ser Tyr Leu Arg Glu Leu Pro Glu 
                325                 330                 335     


Pro Leu Met Xaa Phe Glu Leu Tyr Asp Glu Trp Ile Gln Ala Ser Asn 
            340                 345                 350         


Val Gln Glu Gln Asp Lys Lys Leu Gln Ala Leu Trp Asn Ala Cys Glu 
        355                 360                 365             


Lys Leu Pro Lys Ala Asn His Asn Asn Ile Arg Tyr Leu Ile Lys Phe 
    370                 375                 380                 


Leu Ser Lys Leu Ser Glu Tyr Gln Asp Val Asn Lys Met Xaa Pro Ser 
385                 390                 395                 400 


Asn Met Ala Ile Val Leu Gly Pro Asn Leu Leu Trp Pro Gln Ala Glu 
                405                 410                 415     


Gly Asn Ile Xaa Glu Met Met Xaa Xaa Val Ser Leu Gln Ile Val Gly 
            420                 425                 430         


Ile Ile Glu Pro Ile Ile Gln His Ala Asp Trp Phe Phe Pro Gly Glu 
        435                 440                 445             


Ile Glu Phe Asn Ile Xaa Gly Asn Tyr Gly Ser Pro Val His Val Asn 
    450                 455                 460                 


His Asn Ala Asn Tyr Ser Ser Met Pro Ser Pro Asp Met Asp Pro Ala 
465                 470                 475                 480 


Asp Arg Arg Gln Pro Glu Gln Ala Arg Arg Pro Leu Ser Val Ala Xaa 
                485                 490                 495     


Asp Asn Met Met Leu Glu Phe Tyr Lys Lys Asp Gly Phe Lys Glu Ala 
            500                 505                 510         


Gly Xaa Asp Ser Xaa Gln Gly Pro Leu Trp Pro Ala Gly Gly Tyr Gly 
        515                 520                 525             


Arg Pro Val Arg Trp Pro Ala Val Pro Ser Gln Pro Val Pro His Pro 
    530                 535                 540                 


Ala Gln His Pro Val Xaa Leu Trp Xaa Glu Leu Pro Ser Gly Val Leu 
545                 550                 555                 560 


Leu Gly Leu Gly Pro Ala Leu Pro Ser Cys Ser Ser Ser Pro Gly Leu 
                565                 570                 575     


Ser Phe Cys Leu Tyr Lys His Phe Glu Gln Ile Ala Ala His Ser 
            580                 585                 590     


<210> 2877
<211> 774
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<400> 2877
Met Lys Lys Gln Phe Asn Arg Met Arg Gln Leu Ala Asn Gln Xaa Val 
1               5                   10                  15      


Gly Arg Ala Glu Lys Xaa Glu Val Leu Ser Glu Asp Leu Leu Gln Val 
            20                  25                  30          


Glu Lys Arg Leu Glu Leu Val Lys Gln Val Ser His Ser Xaa His Lys 
        35                  40                  45              


Lys Leu Xaa Ala Cys Leu Gln Gly Gln Gln Gly Ala Glu Ala Asp Lys 
    50                  55                  60                  


Arg Ser Lys Lys Leu Pro Leu Xaa Xaa Leu Ala Gln Cys Leu Met Glu 
65                  70                  75                  80  


Gly Ser Ala Ile Leu Gly Asp Asp Xaa Leu Leu Gly Lys Met Leu Lys 
                85                  90                  95      


Leu Cys Gly Glu Xaa Glu Asp Lys Leu Ala Gln Glu Leu Ile His Phe 
            100                 105                 110         


Glu Leu Gln Val Glu Arg Asp Val Ile Glu Pro Leu Phe Leu Leu Ala 
        115                 120                 125             


Glu Val Glu Ile Pro Asn Ile Gln Lys Gln Arg Lys His Leu Ala Lys 
    130                 135                 140                 


Leu Val Leu Asp Met Asp Ser Ser Arg Xaa Arg Trp Gln Gln Xaa Ser 
145                 150                 155                 160 


Lys Ser Ser Gly Leu Ser Ser Ser Leu Gln Pro Ala Gly Ala Lys Ala 
                165                 170                 175     


Asp Ala Leu Arg Glu Glu Met Glu Glu Ala Ala Asn Arg Val Glu Ile 
            180                 185                 190         


Cys Arg Asp Gln Leu Ser Ala Asp Met Tyr Ser Phe Val Ala Lys Glu 
        195                 200                 205             


Ile Asp Tyr Ala Asn Tyr Phe Gln Xaa Leu Ile Glu Val Gln Ala Glu 
    210                 215                 220                 


Tyr His Arg Lys Ser Leu Xaa Leu Leu Gln Ala Val Leu Pro Gln Ile 
225                 230                 235                 240 


Lys Ala Gln Gln Glu Ala Trp Val Glu Lys Pro Ser Phe Gly Lys Pro 
                245                 250                 255     


Leu Glu Glu His Leu Xaa Ile Ser Gly Arg Glu Ile Ala Phe Pro Ile 
            260                 265                 270         


Glu Ala Cys Val Xaa Met Leu Leu Glu Cys Gly Met Gln Glu Glu Gly 
        275                 280                 285             


Leu Phe Arg Val Ala Pro Ser Ala Ser Lys Leu Lys Lys Leu Lys Ala 
    290                 295                 300                 


Ala Leu Asp Cys Cys Val Val Asp Val Gln Glu Tyr Ser Ala Asp Pro 
305                 310                 315                 320 


His Ala Ile Ala Gly Ala Leu Lys Ser Tyr Leu Arg Glu Leu Pro Glu 
                325                 330                 335     


Pro Leu Met Xaa Phe Glu Leu Tyr Asp Glu Trp Ile Gln Ala Ser Asn 
            340                 345                 350         


Val Gln Glu Gln Asp Lys Lys Leu Gln Ala Leu Trp Asn Ala Cys Glu 
        355                 360                 365             


Lys Leu Pro Lys Ala Asn His Asn Asn Ile Arg Tyr Leu Ile Lys Phe 
    370                 375                 380                 


Leu Ser Lys Leu Ser Glu Tyr Gln Asp Val Asn Lys Met Xaa Pro Ser 
385                 390                 395                 400 


Asn Met Ala Ile Val Leu Gly Pro Asn Leu Leu Trp Pro Gln Ala Glu 
                405                 410                 415     


Gly Asn Ile Xaa Glu Met Met Xaa Xaa Val Ser Leu Gln Ile Val Gly 
            420                 425                 430         


Ile Ile Glu Pro Ile Ile Gln His Ala Asp Trp Phe Phe Pro Gly Glu 
        435                 440                 445             


Ile Glu Phe Asn Ile Xaa Gly Asn Tyr Gly Ser Pro Val His Val Asn 
    450                 455                 460                 


His Asn Ala Asn Tyr Ser Ser Met Pro Ser Pro Asp Met Asp Pro Ala 
465                 470                 475                 480 


Asp Arg Arg Gln Pro Glu Gln Ala Arg Arg Pro Leu Ser Val Ala Xaa 
                485                 490                 495     


Asp Asn Met Met Leu Glu Phe Tyr Lys Lys Asp Gly Leu Arg Lys Ile 
            500                 505                 510         


Gln Ser Met Gly Val Arg Val Met Asp Xaa Asn Trp Val Ala Arg Arg 
        515                 520                 525             


Gly Ser Ser Ala Gly Arg Lys Val Ser Cys Ala Pro Pro Ser Met Gln 
    530                 535                 540                 


Pro Pro Ala Pro Pro Ala Glu Leu Ala Ala Pro Leu Pro Ser Pro Leu 
545                 550                 555                 560 


Pro Glu Gln Pro Leu Asp Ser Pro Ala Ala Pro Ala Leu Ser Pro Ser 
                565                 570                 575     


Gly Leu Gly Leu Gln Pro Gly Pro Glu Arg Xaa Ser Xaa Xaa Lys Ser 
            580                 585                 590         


Lys Glu Leu Ser Pro Gly Ser Ala Gln Lys Gly Ser Pro Gly Ser Ser 
        595                 600                 605             


Gln Gly Xaa Ala Cys Ala Gly Xaa Gln Pro Gly Ala Gln Pro Gly Ala 
    610                 615                 620                 


Gln Pro Gly Ala Ser Pro Ser Pro Ser Gln Pro Pro Ala Asp Gln Ser 
625                 630                 635                 640 


Pro His Xaa Leu Arg Lys Val Ser Lys Lys Leu Ala Pro Ile Pro Pro 
                645                 650                 655     


Lys Val Pro Phe Gly Gln Pro Gly Ala Met Ala Asp Gln Ser Ala Gly 
            660                 665                 670         


Gln Pro Ser Pro Val Ser Leu Ser Pro Xaa Pro Pro Ser Xaa Pro Ser 
        675                 680                 685             


Pro Tyr Gly Leu Ser Tyr Pro Gln Gly Tyr Ser Leu Ala Ser Gly Gln 
    690                 695                 700                 


Leu Ser Pro Ala Ala Ala Pro Pro Leu Ala Ser Pro Ser Val Phe Xaa 
705                 710                 715                 720 


Ser Xaa Leu Ser Lys Ser Arg Pro Xaa Pro Lys Pro Arg Gln Arg Pro 
                725                 730                 735     


Xaa Leu Pro Pro Pro Gln Pro Pro Xaa Val Asn Leu Ser Ala Ser Ser 
            740                 745                 750         


Pro Gln Ser Xaa Glu Ala Pro Met Leu Asp Gly Met Ser Pro Gly Glu 
        755                 760                 765             


Ser Met Ser Xaa Ala Val 
    770                 


<210> 2878
<211> 812
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<400> 2878
Met Lys Lys Gln Phe Asn Arg Met Arg Gln Leu Ala Asn Gln Xaa Val 
1               5                   10                  15      


Gly Arg Ala Glu Lys Xaa Glu Val Leu Ser Glu Asp Leu Leu Gln Val 
            20                  25                  30          


Glu Lys Arg Leu Glu Leu Val Lys Gln Val Ser His Ser Xaa His Lys 
        35                  40                  45              


Lys Leu Xaa Ala Cys Leu Gln Gly Gln Gln Gly Ala Glu Ala Asp Lys 
    50                  55                  60                  


Arg Ser Lys Lys Leu Pro Leu Xaa Xaa Leu Ala Gln Cys Leu Met Glu 
65                  70                  75                  80  


Gly Ser Ala Ile Leu Gly Asp Asp Xaa Leu Leu Gly Lys Met Leu Lys 
                85                  90                  95      


Leu Cys Gly Glu Xaa Glu Asp Lys Leu Ala Gln Glu Leu Ile His Phe 
            100                 105                 110         


Glu Leu Gln Val Glu Arg Asp Val Ile Glu Pro Leu Phe Leu Leu Ala 
        115                 120                 125             


Glu Val Glu Ile Pro Asn Ile Gln Lys Gln Arg Lys His Leu Ala Lys 
    130                 135                 140                 


Leu Val Leu Asp Met Asp Ser Ser Arg Xaa Arg Trp Gln Gln Xaa Ser 
145                 150                 155                 160 


Lys Ser Ser Gly Leu Ser Ser Ser Leu Gln Pro Ala Gly Ala Lys Ala 
                165                 170                 175     


Asp Ala Leu Arg Glu Glu Met Glu Glu Ala Ala Asn Arg Val Glu Ile 
            180                 185                 190         


Cys Arg Asp Gln Leu Ser Ala Asp Met Tyr Ser Phe Val Ala Lys Glu 
        195                 200                 205             


Ile Asp Tyr Ala Asn Tyr Phe Gln Xaa Leu Ile Glu Val Gln Ala Glu 
    210                 215                 220                 


Tyr His Arg Lys Ser Leu Xaa Leu Leu Gln Ala Val Leu Pro Gln Ile 
225                 230                 235                 240 


Lys Ala Gln Gln Glu Ala Trp Val Glu Lys Pro Ser Phe Gly Lys Pro 
                245                 250                 255     


Leu Glu Glu His Leu Xaa Ile Ser Gly Arg Glu Ile Ala Phe Pro Ile 
            260                 265                 270         


Glu Ala Cys Val Xaa Met Leu Leu Glu Cys Gly Met Gln Glu Glu Gly 
        275                 280                 285             


Leu Phe Arg Val Ala Pro Ser Ala Ser Lys Leu Lys Lys Leu Lys Ala 
    290                 295                 300                 


Ala Leu Asp Cys Cys Val Val Asp Val Gln Glu Tyr Ser Ala Asp Pro 
305                 310                 315                 320 


His Ala Ile Ala Gly Ala Leu Lys Ser Tyr Leu Arg Glu Leu Pro Glu 
                325                 330                 335     


Pro Leu Met Xaa Phe Glu Leu Tyr Asp Glu Trp Ile Gln Ala Ser Asn 
            340                 345                 350         


Val Gln Glu Gln Asp Lys Lys Leu Gln Ala Leu Trp Asn Ala Cys Glu 
        355                 360                 365             


Lys Leu Pro Lys Ala Asn His Asn Asn Ile Arg Tyr Leu Ile Lys Phe 
    370                 375                 380                 


Leu Ser Lys Leu Ser Glu Tyr Gln Asp Val Asn Lys Met Xaa Pro Ser 
385                 390                 395                 400 


Asn Met Ala Ile Val Leu Gly Pro Asn Leu Leu Trp Pro Gln Ala Glu 
                405                 410                 415     


Gly Asn Ile Xaa Glu Met Met Xaa Xaa Val Ser Leu Gln Ile Val Gly 
            420                 425                 430         


Ile Ile Glu Pro Ile Ile Gln His Ala Asp Trp Phe Phe Pro Gly Glu 
        435                 440                 445             


Ile Glu Phe Asn Ile Xaa Gly Asn Tyr Gly Ser Pro Val His Val Asn 
    450                 455                 460                 


His Asn Ala Asn Tyr Ser Ser Met Pro Ser Pro Asp Met Asp Pro Ala 
465                 470                 475                 480 


Asp Arg Arg Gln Pro Glu Gln Ala Arg Arg Pro Leu Ser Val Ala Xaa 
                485                 490                 495     


Asp Asn Met Met Leu Glu Phe Tyr Lys Lys Asp Gly Met Gly Val Arg 
            500                 505                 510         


Val Met Asp Xaa Asn Trp Val Ala Arg Arg Gly Ser Ser Ala Gly Arg 
        515                 520                 525             


Lys Val Ser Cys Ala Pro Pro Ser Met Gln Pro Pro Ala Pro Pro Ala 
    530                 535                 540                 


Glu Leu Ala Ala Pro Leu Pro Ser Pro Leu Pro Glu Gln Pro Leu Asp 
545                 550                 555                 560 


Ser Pro Ala Ala Pro Ala Leu Ser Pro Ser Gly Leu Gly Leu Gln Pro 
                565                 570                 575     


Gly Pro Glu Arg Xaa Ser Xaa Xaa Lys Ser Lys Glu Leu Ser Pro Gly 
            580                 585                 590         


Ser Ala Gln Lys Gly Ser Pro Gly Ser Ser Gln Gly Xaa Ala Cys Ala 
        595                 600                 605             


Gly Xaa Gln Pro Gly Ala Gln Pro Gly Ala Gln Pro Gly Ala Ser Pro 
    610                 615                 620                 


Ser Pro Ser Gln Pro Pro Ala Asp Gln Ser Pro His Xaa Leu Arg Lys 
625                 630                 635                 640 


Val Ser Lys Lys Leu Ala Pro Ile Pro Pro Lys Val Pro Phe Gly Gln 
                645                 650                 655     


Pro Gly Ala Met Ala Asp Gln Ser Ala Gly Gln Pro Ser Pro Val Ser 
            660                 665                 670         


Leu Ser Pro Xaa Pro Pro Ser Xaa Pro Ser Pro Tyr Gly Leu Ser Tyr 
        675                 680                 685             


Pro Gln Gly Tyr Ser Leu Ala Ser Gly Gln Leu Ser Pro Ala Ala Ala 
    690                 695                 700                 


Pro Pro Leu Ala Ser Pro Ser Val Phe Xaa Ser Xaa Leu Ser Lys Ser 
705                 710                 715                 720 


Arg Pro Xaa Pro Lys Pro Arg Gln Arg Pro Xaa Leu Pro Pro Pro Gln 
                725                 730                 735     


Pro Pro Xaa Val Asn Leu Ser Ala Ser Ser Pro Gln Ser Xaa Glu Ala 
            740                 745                 750         


Pro Met Leu Asp Gly Met Ser Pro Gly Glu Ser Met Ser Xaa Asp Leu 
        755                 760                 765             


Val His Phe Asp Ile Pro Ser Ile His Ile Glu Leu Gly Ser Xaa Leu 
    770                 775                 780                 


Arg Leu Ser Pro Leu Glu His Met Arg Arg His Ser Val Xaa Asp Lys 
785                 790                 795                 800 


Arg Asp Ser Glu Glu Glu Ser Glu Ser Xaa Ala Leu 
                805                 810         


<210> 2879
<211> 818
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<400> 2879
Met Lys Lys Gln Phe Asn Arg Met Arg Gln Leu Ala Asn Gln Xaa Val 
1               5                   10                  15      


Gly Arg Ala Glu Lys Xaa Glu Val Leu Ser Glu Asp Leu Leu Gln Val 
            20                  25                  30          


Glu Lys Arg Leu Glu Leu Val Lys Gln Val Ser His Ser Xaa His Lys 
        35                  40                  45              


Lys Leu Xaa Ala Cys Leu Gln Gly Gln Gln Gly Ala Glu Ala Asp Lys 
    50                  55                  60                  


Arg Ser Lys Lys Leu Pro Leu Xaa Xaa Leu Ala Gln Cys Leu Met Glu 
65                  70                  75                  80  


Gly Ser Ala Ile Leu Gly Asp Asp Xaa Leu Leu Gly Lys Met Leu Lys 
                85                  90                  95      


Leu Cys Gly Glu Xaa Glu Asp Lys Leu Ala Gln Glu Leu Ile His Phe 
            100                 105                 110         


Glu Leu Gln Val Glu Arg Asp Val Ile Glu Pro Leu Phe Leu Leu Ala 
        115                 120                 125             


Glu Val Glu Ile Pro Asn Ile Gln Lys Gln Arg Lys His Leu Ala Lys 
    130                 135                 140                 


Leu Val Leu Asp Met Asp Ser Ser Arg Xaa Arg Trp Gln Gln Xaa Ser 
145                 150                 155                 160 


Lys Ser Ser Gly Leu Ser Ser Ser Leu Gln Pro Ala Gly Ala Lys Ala 
                165                 170                 175     


Asp Ala Leu Arg Glu Glu Met Glu Glu Ala Ala Asn Arg Val Glu Ile 
            180                 185                 190         


Cys Arg Asp Gln Leu Ser Ala Asp Met Tyr Ser Phe Val Ala Lys Glu 
        195                 200                 205             


Ile Asp Tyr Ala Asn Tyr Phe Gln Xaa Leu Ile Glu Val Gln Ala Glu 
    210                 215                 220                 


Tyr His Arg Lys Ser Leu Xaa Leu Leu Gln Ala Val Leu Pro Gln Ile 
225                 230                 235                 240 


Lys Ala Gln Gln Glu Ala Trp Val Glu Lys Pro Ser Phe Gly Lys Pro 
                245                 250                 255     


Leu Glu Glu His Leu Xaa Ile Ser Gly Arg Glu Ile Ala Phe Pro Ile 
            260                 265                 270         


Glu Ala Cys Val Xaa Met Leu Leu Glu Cys Gly Met Gln Glu Glu Gly 
        275                 280                 285             


Leu Phe Arg Val Ala Pro Ser Ala Ser Lys Leu Lys Lys Leu Lys Ala 
    290                 295                 300                 


Ala Leu Asp Cys Cys Val Val Asp Val Gln Glu Tyr Ser Ala Asp Pro 
305                 310                 315                 320 


His Ala Ile Ala Gly Ala Leu Lys Ser Tyr Leu Arg Glu Leu Pro Glu 
                325                 330                 335     


Pro Leu Met Xaa Phe Glu Leu Tyr Asp Glu Trp Ile Gln Ala Ser Asn 
            340                 345                 350         


Val Gln Glu Gln Asp Lys Lys Leu Gln Ala Leu Trp Asn Ala Cys Glu 
        355                 360                 365             


Lys Leu Pro Lys Ala Asn His Asn Asn Ile Arg Tyr Leu Ile Lys Phe 
    370                 375                 380                 


Leu Ser Lys Leu Ser Glu Tyr Gln Asp Val Asn Lys Met Xaa Pro Ser 
385                 390                 395                 400 


Asn Met Ala Ile Val Leu Gly Pro Asn Leu Leu Trp Pro Gln Ala Glu 
                405                 410                 415     


Gly Asn Ile Xaa Glu Met Met Xaa Xaa Val Ser Leu Gln Ile Val Gly 
            420                 425                 430         


Ile Ile Glu Pro Ile Ile Gln His Ala Asp Trp Phe Phe Pro Gly Glu 
        435                 440                 445             


Ile Glu Phe Asn Ile Xaa Gly Asn Tyr Gly Ser Pro Val His Val Asn 
    450                 455                 460                 


His Asn Ala Asn Tyr Ser Ser Met Pro Ser Pro Asp Met Asp Pro Ala 
465                 470                 475                 480 


Asp Arg Arg Gln Pro Glu Gln Ala Arg Arg Pro Leu Ser Val Ala Xaa 
                485                 490                 495     


Asp Asn Met Met Leu Glu Phe Tyr Lys Lys Asp Gly Leu Arg Lys Ile 
            500                 505                 510         


Gln Ser Met Gly Val Arg Val Met Asp Xaa Asn Trp Val Ala Arg Arg 
        515                 520                 525             


Gly Ser Ser Ala Gly Arg Lys Val Ser Cys Ala Pro Pro Ser Met Gln 
    530                 535                 540                 


Pro Pro Ala Pro Pro Ala Glu Leu Ala Ala Pro Leu Pro Ser Pro Leu 
545                 550                 555                 560 


Pro Glu Gln Pro Leu Asp Ser Pro Ala Ala Pro Ala Leu Ser Pro Ser 
                565                 570                 575     


Gly Leu Gly Leu Gln Pro Gly Pro Glu Arg Xaa Ser Xaa Xaa Lys Ser 
            580                 585                 590         


Lys Glu Leu Ser Pro Gly Ser Ala Gln Lys Gly Ser Pro Gly Ser Ser 
        595                 600                 605             


Gln Gly Xaa Ala Cys Ala Gly Xaa Gln Pro Gly Ala Gln Pro Gly Ala 
    610                 615                 620                 


Gln Pro Gly Ala Ser Pro Ser Pro Ser Gln Pro Pro Ala Asp Gln Ser 
625                 630                 635                 640 


Pro His Xaa Leu Arg Lys Val Ser Lys Lys Leu Ala Pro Ile Pro Pro 
                645                 650                 655     


Lys Val Pro Phe Gly Gln Pro Gly Ala Met Ala Asp Gln Ser Ala Gly 
            660                 665                 670         


Gln Pro Ser Pro Val Ser Leu Ser Pro Xaa Pro Pro Ser Xaa Pro Ser 
        675                 680                 685             


Pro Tyr Gly Leu Ser Tyr Pro Gln Gly Tyr Ser Leu Ala Ser Gly Gln 
    690                 695                 700                 


Leu Ser Pro Ala Ala Ala Pro Pro Leu Ala Ser Pro Ser Val Phe Xaa 
705                 710                 715                 720 


Ser Xaa Leu Ser Lys Ser Arg Pro Xaa Pro Lys Pro Arg Gln Arg Pro 
                725                 730                 735     


Xaa Leu Pro Pro Pro Gln Pro Pro Xaa Val Asn Leu Ser Ala Ser Ser 
            740                 745                 750         


Pro Gln Ser Xaa Glu Ala Pro Met Leu Asp Gly Met Ser Pro Gly Glu 
        755                 760                 765             


Ser Met Ser Xaa Asp Leu Val His Phe Asp Ile Pro Ser Ile His Ile 
    770                 775                 780                 


Glu Leu Gly Ser Xaa Leu Arg Leu Ser Pro Leu Glu His Met Arg Arg 
785                 790                 795                 800 


His Ser Val Xaa Asp Lys Arg Asp Ser Glu Glu Glu Ser Glu Ser Xaa 
                805                 810                 815     


Ala Leu 
        


<210> 2880
<211> 116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<400> 2880
Met Leu Leu Glu Cys Gly Met Gln Glu Glu Gly Leu Phe Arg Val Ala 
1               5                   10                  15      


Pro Ser Ala Ser Lys Leu Lys Lys Leu Lys Ala Ala Leu Asp Cys Cys 
            20                  25                  30          


Val Val Asp Val Gln Glu Tyr Ser Ala Asp Pro His Ala Ile Ala Gly 
        35                  40                  45              


Ala Leu Lys Ser Tyr Leu Arg Glu Leu Pro Glu Pro Leu Met Xaa Phe 
    50                  55                  60                  


Glu Leu Tyr Asp Glu Trp Ile Gln Ala Ser Asn Val Gln Glu Gln Asp 
65                  70                  75                  80  


Lys Lys Leu Gln Ala Leu Trp Asn Ala Cys Glu Lys Leu Pro Lys Ala 
                85                  90                  95      


Asn His Asn Asn Ile Arg Tyr Leu Ile Lys Phe Tyr Pro Ser Cys Gln 
            100                 105                 110         


Asn Ile Lys Met 
        115     


<210> 2881
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<400> 2881
Met Xaa Pro Ser Asn Met Ala Ile Val Leu Gly Pro Asn Leu Leu Trp 
1               5                   10                  15      


Pro Gln Ala Glu Gly Asn Ile Xaa Glu Met Met Xaa Xaa Val Ser Leu 
            20                  25                  30          


Gln Ile Val Gly Ile Ile Glu Pro Ile Ile Gln His Ala Asp Trp Phe 
        35                  40                  45              


Phe Pro Gly Glu Ile Glu Phe Asn Ile Xaa Gly Asn Tyr Gly Ser Pro 
    50                  55                  60                  


Val His Val Asn His Asn Ala Asn Tyr Ser Ser Met Pro Ser Pro Asp 
65                  70                  75                  80  


Met Asp Pro Ala Asp Arg Arg Gln Pro Glu Gln Ala Arg Arg Pro Leu 
                85                  90                  95      


Ser Val Ala Xaa Asp Asn Met Met Leu Glu Phe Tyr Lys Lys Asp Gly 
            100                 105                 110         


Leu Arg Lys Ile Gln Ser Met Gly Val Arg Val Met Asp Xaa Asn Trp 
        115                 120                 125             


Val Ala Arg Arg Gly Ser Ser Ala Gly Arg Lys Val Ser Cys Ala Pro 
    130                 135                 140                 


Pro Ser Met Gln Pro Pro Ala Pro Pro Ala Glu Leu Ala Ala Pro Leu 
145                 150                 155                 160 


Pro Ser Pro Leu Pro Glu Gln Pro Leu Asp Ser Pro Ala Ala Pro Ala 
                165                 170                 175     


Leu Ser Pro Ser Gly Leu Gly Leu Gln Pro Gly Pro Glu Arg Xaa 
            180                 185                 190     


<210> 2882
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<400> 2882
Xaa Gly Ser Ser Gln Gly Xaa Ala Cys Ala Gly Xaa Gln Pro Gly Ala 
1               5                   10                  15      


Gln Pro Gly Ala Gln Pro Gly Ala Ser Pro Ser Pro Ser Gln Pro Pro 
            20                  25                  30          


Ala Asp Gln Ser Pro His Xaa Leu Arg Lys Val Ser Lys Lys Leu Ala 
        35                  40                  45              


Pro Ile Pro Pro Lys Val Pro Phe Gly Gln Pro Gly Ala Met Ala Asp 
    50                  55                  60                  


Gln Ser Ala Gly Gln Pro Ser Pro Val Ser Leu Ser Pro Xaa Pro Pro 
65                  70                  75                  80  


Ser Xaa Pro Ser Pro Tyr Gly Leu Ser Tyr Pro Gln Gly Tyr Ser Leu 
                85                  90                  95      


Ala Ser Gly Gln Leu Ser Pro Ala Ala Ala Pro Pro Leu Ala Ser Pro 
            100                 105                 110         


Ser Val Phe Xaa Ser Xaa Leu Ser Lys Ser Arg Pro Xaa Pro Lys Pro 
        115                 120                 125             


Arg Gln Arg Pro Xaa Leu Pro Pro Pro Gln Pro Pro Xaa Val Asn Leu 
    130                 135                 140                 


Ser Ala Ser Ser Pro Gln Ser Xaa Glu Ala Pro Met Leu Asp Gly Met 
145                 150                 155                 160 


Ser Pro Gly Glu Ser Met Ser Xaa Gly Asn Gln Ala Xaa Gly Ser Leu 
                165                 170                 175     


Xaa Phe Phe Tyr Glu Leu 
            180         


<210> 2883
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<400> 2883
Gly Arg Gln Asp Gly Ser Glu Ser Glu Ala Val Ala Val Ala Leu Ala 
1               5                   10                  15      


Gly Arg Leu Arg Glu Leu Leu Arg Asp Leu Pro Pro Glu Asn Arg Ala 
            20                  25                  30          


Ser Leu Gln Tyr Leu Leu Arg His Leu Arg Arg Pro Ala Ser Ser Arg 
        35                  40                  45              


Leu Ser Ser Ser Xaa Xaa Ala Trp Ser Ser Arg Arg Ser Arg Arg Arg 
    50                  55                  60                  


Pro Pro Gly Ala Arg Xaa Ser His Pro Xaa Ser Glu Leu Arg 
65                  70                  75              


<210> 2884
<211> 1019
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1007)..(1007)
<223> Selenocysteine

<400> 2884
Met Cys Ile Cys Gly Xaa Ala His Pro Val Leu Asp Glu Gly Pro Val 
1               5                   10                  15      


Arg Cys Arg Ala Gly Pro Arg Asp Leu Leu Glu Ala Arg Arg Pro Arg 
            20                  25                  30          


Ala His Glu Cys Leu Gly Glu Ala Leu Arg Val Met His Gln Ile Ile 
        35                  40                  45              


Ser Lys Tyr Pro Leu Leu Asn Xaa Val Glu Xaa Leu Xaa Ala Ala Gly 
    50                  55                  60                  


Xaa Leu Ile Ala Lys Val Lys Ala Phe His Tyr Glu Ser Asn Asn Asp 
65                  70                  75                  80  


Leu Glu Lys Gln Glu Phe Glu Lys Ala Leu Glu Xaa Ile Ala Val Ala 
                85                  90                  95      


Phe Ser Ser Xaa Val Ser Glu Phe Leu Met Gly Glu Val Asp Ser Ser 
            100                 105                 110         


Xaa Leu Leu Ala Val Pro Pro Gly Asp Ser Ser Gln Ser Met Glu Ser 
        115                 120                 125             


Leu Tyr Gly Pro Gly Ser Glu Gly Xaa Pro Pro Ser Leu Glu Asp Cys 
    130                 135                 140                 


Asp Ala Gly Cys Leu Pro Ala Glu Glu Val Asp Val Leu Leu Gln Arg 
145                 150                 155                 160 


Cys Glu Gly Gly Val Asp Ala Ala Leu Leu Tyr Ala Lys Asn Met Ala 
                165                 170                 175     


Lys Tyr Met Lys Asp Leu Ile Ser Tyr Leu Glu Lys Arg Xaa Xaa Leu 
            180                 185                 190         


Glu Met Glu Phe Ala Lys Gly Leu Gln Lys Ile Ala His Asn Cys Arg 
        195                 200                 205             


Gln Ser Val Met Gln Glu Pro His Met Pro Leu Leu Ser Ile Tyr Ser 
    210                 215                 220                 


Leu Ala Leu Glu Gln Asp Leu Glu Phe Gly His Ser Met Val Gln Ala 
225                 230                 235                 240 


Val Gly Xaa Leu Gln Xaa Gln Xaa Phe Met Gln Pro Leu Xaa Leu Arg 
                245                 250                 255     


Arg Leu Glu His Glu Lys Arg Arg Lys Glu Ile Lys Glu Ala Trp His 
            260                 265                 270         


Arg Ala Gln Arg Lys Leu Gln Glu Ala Glu Ser Asn Leu Arg Lys Ala 
        275                 280                 285             


Lys Gln Gly Tyr Val Gln Arg Cys Glu Asp His Asp Lys Ala Arg Phe 
    290                 295                 300                 


Leu Val Ala Lys Ala Glu Glu Glu Gln Ala Gly Ser Ala Pro Gly Ala 
305                 310                 315                 320 


Gly Ser Xaa Ala Xaa Lys Xaa Leu Asp Lys Arg Arg Arg Leu Glu Glu 
                325                 330                 335     


Glu Ala Lys Asn Lys Ala Glu Glu Ala Met Ala Xaa Tyr Arg Xaa Cys 
            340                 345                 350         


Val Ala Asp Ala Lys Xaa Gln Lys Gln Glu Leu Glu Asp Xaa Lys Val 
        355                 360                 365             


Xaa Ala Leu Arg Gln Ile Gln Glu Val Ile Arg Gln Ser Asp Gln Xaa 
    370                 375                 380                 


Ile Lys Ser Ala Xaa Ile Ser Tyr Tyr Gln Met Met His Met Gln Xaa 
385                 390                 395                 400 


Ala Pro Leu Pro Val His Phe Gln Met Leu Cys Glu Ser Ser Lys Leu 
                405                 410                 415     


Tyr Asp Pro Gly Gln Gln Tyr Ala Ser His Val Arg Gln Leu Gln Arg 
            420                 425                 430         


Asp Gln Glu Pro Asp Val His Tyr Asp Phe Glu Pro His Val Ser Ala 
        435                 440                 445             


Asn Ala Trp Ser Pro Val Met Arg Ala Arg Lys Ser Ser Phe Asn Val 
    450                 455                 460                 


Ser Asp Val Ala Arg Pro Glu Ala Ala Gly Ser Pro Pro Glu Glu Gly 
465                 470                 475                 480 


Gly Cys Xaa Glu Gly Xaa Pro Ala Lys Asp His Arg Ala Gly Arg Gly 
                485                 490                 495     


His Gln Val His Lys Ser Trp Pro Leu Ser Ile Ser Asp Ser Asp Ser 
            500                 505                 510         


Gly Leu Asp Pro Gly Pro Gly Ala Gly Asp Phe Lys Lys Phe Glu Arg 
        515                 520                 525             


Xaa Ser Ser Ser Gly Xaa Met Ser Ser Xaa Glu Glu Leu Val Asp Pro 
    530                 535                 540                 


Asp Gly Gly Ala Gly Ala Ser Ala Phe Glu Gln Ala Asp Leu Asn Gly 
545                 550                 555                 560 


Met Xaa Pro Glu Leu Pro Val Ala Val Pro Ser Gly Pro Phe Arg His 
                565                 570                 575     


Glu Gly Leu Ser Lys Ala Ala Arg Xaa His Arg Leu Arg Lys Leu Arg 
            580                 585                 590         


Xaa Pro Ala Lys Cys Arg Glu Cys Asn Ser Tyr Val Tyr Phe Gln Gly 
        595                 600                 605             


Ala Glu Cys Glu Glu Cys Cys Leu Ala Cys His Lys Lys Cys Leu Glu 
    610                 615                 620                 


Xaa Leu Ala Ile Gln Cys Gly His Lys Lys Leu Gln Gly Arg Leu Gln 
625                 630                 635                 640 


Leu Phe Gly Gln Asp Phe Ser His Ala Ala Arg Ser Ala Pro Asp Gly 
                645                 650                 655     


Val Pro Phe Ile Val Lys Lys Cys Val Cys Glu Ile Glu Arg Arg Ala 
            660                 665                 670         


Leu Arg Xaa Lys Gly Ile Tyr Arg Val Asn Gly Val Lys Xaa Arg Val 
        675                 680                 685             


Glu Lys Leu Cys Gln Ala Phe Glu Asn Gly Lys Glu Leu Val Glu Leu 
    690                 695                 700                 


Ser Gln Ala Ser Pro His Asp Ile Ser Asn Val Leu Lys Leu Tyr Leu 
705                 710                 715                 720 


Arg Gln Leu Pro Glu Pro Leu Ile Ser Phe Arg Leu Tyr His Glu Leu 
                725                 730                 735     


Val Gly Leu Ala Lys Asp Ser Leu Lys Ala Glu Ala Glu Ala Lys Ala 
            740                 745                 750         


Ala Ser Arg Gly Arg Gln Asp Gly Ser Glu Ser Glu Ala Val Ala Val 
        755                 760                 765             


Ala Leu Ala Gly Arg Leu Arg Glu Leu Leu Arg Asp Leu Pro Pro Glu 
    770                 775                 780                 


Asn Arg Ala Ser Leu Gln Tyr Leu Leu Arg His Leu Arg Arg Ile Val 
785                 790                 795                 800 


Glu Val Glu Gln Asp Asn Lys Met Xaa Pro Gly Asn Leu Gly Ile Val 
                805                 810                 815     


Phe Gly Pro Xaa Leu Leu Arg Pro Arg Pro Xaa Glu Ala Xaa Val Ser 
            820                 825                 830         


Leu Ser Ser Leu Val Asp Tyr Pro His Gln Ala Arg Val Ile Glu Xaa 
        835                 840                 845             


Leu Ile Val His Tyr Gly Leu Val Phe Glu Glu Glu Pro Glu Glu Xaa 
    850                 855                 860                 


Pro Gly Gly Gln Asp Glu Ser Ser Asn Gln Arg Ala Glu Val Val Val 
865                 870                 875                 880 


Gln Val Pro Tyr Leu Glu Ala Gly Glu Ala Val Val Tyr Pro Leu Gln 
                885                 890                 895     


Glu Ala Ala Ala Asp Gly Cys Arg Glu Ser Arg Val Val Ser Asn Asp 
            900                 905                 910         


Ser Asp Ser Asp Leu Glu Glu Ala Ser Glu Leu Leu Ser Ser Ser Glu 
        915                 920                 925             


Ala Ser Ala Leu Gly His Leu Ser Phe Leu Glu Gln Gln Gln Ser Glu 
    930                 935                 940                 


Ala Ser Leu Glu Val Ala Ser Gly Ser His Ser Gly Ser Glu Glu Gln 
945                 950                 955                 960 


Leu Glu Ala Xaa Ala Arg Glu Asp Gly Asp Gly Asp Glu Asp Gly Pro 
                965                 970                 975     


Ala Gln Gln Leu Ser Gly Phe Asn Xaa Asn Gln Ser Asn Asn Val Leu 
            980                 985                 990         


Gln Ala Pro Leu Pro Pro Met Arg  Leu Arg Gly Gly Arg  Met Xaa Leu 
        995                 1000                 1005             


Gly Ser  Cys Arg Glu Arg Gln  Pro Glu Phe Val 
    1010                 1015                 


<210> 2885
<211> 1136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<400> 2885
Met Phe Ser Arg Lys Lys Arg Glu Leu Met Lys Xaa Pro Ser Ile Ser 
1               5                   10                  15      


Lys Lys Asn Arg Ala Gly Ser Pro Ser Pro Gln Pro Ser Gly Glu Leu 
            20                  25                  30          


Pro Arg Lys Asp Gly Ala Asp Ala Val Phe Pro Gly Pro Ser Leu Glu 
        35                  40                  45              


Pro Pro Ala Gly Ser Ser Gly Val Lys Ala Xaa Gly Xaa Leu Lys Arg 
    50                  55                  60                  


Pro Xaa Ser Leu Ser Arg His Ala Ser Ala Ala Gly Phe Pro Leu Ser 
65                  70                  75                  80  


Gly Ala Ala Ser Trp Xaa Leu Gly Arg Ser His Arg Ser Pro Leu Xaa 
                85                  90                  95      


Ala Ala Ser Pro Gly Glu Leu Pro Xaa Glu Gly Ala Gly Pro Asp Val 
            100                 105                 110         


Val Glu Asp Ile Ser His Leu Leu Ala Asp Val Ala Arg Phe Ala Glu 
        115                 120                 125             


Gly Leu Glu Lys Leu Lys Glu Cys Val Leu Arg Asp Asp Leu Leu Glu 
    130                 135                 140                 


Ala Arg Arg Pro Arg Ala His Glu Cys Leu Gly Glu Ala Leu Arg Val 
145                 150                 155                 160 


Met His Gln Ile Ile Ser Lys Tyr Pro Leu Leu Asn Xaa Val Glu Xaa 
                165                 170                 175     


Leu Xaa Ala Ala Gly Xaa Leu Ile Ala Lys Val Lys Ala Phe His Tyr 
            180                 185                 190         


Glu Ser Asn Asn Asp Leu Glu Lys Gln Glu Phe Glu Lys Ala Leu Glu 
        195                 200                 205             


Xaa Ile Ala Val Ala Phe Ser Ser Xaa Val Ser Glu Phe Leu Met Gly 
    210                 215                 220                 


Glu Val Asp Ser Ser Xaa Leu Leu Ala Val Pro Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Gln Ser Met Glu Ser Leu Tyr Gly Pro Gly Ser Glu Gly Xaa Pro Pro 
                245                 250                 255     


Ser Leu Glu Asp Cys Asp Ala Gly Cys Leu Pro Ala Glu Glu Val Asp 
            260                 265                 270         


Val Leu Leu Gln Arg Cys Glu Gly Gly Val Asp Ala Ala Leu Leu Tyr 
        275                 280                 285             


Ala Lys Asn Met Ala Lys Tyr Met Lys Asp Leu Ile Ser Tyr Leu Glu 
    290                 295                 300                 


Lys Arg Xaa Xaa Leu Glu Met Glu Phe Ala Lys Gly Leu Gln Lys Ile 
305                 310                 315                 320 


Ala His Asn Cys Arg Gln Ser Val Met Gln Glu Pro His Met Pro Leu 
                325                 330                 335     


Leu Ser Ile Tyr Ser Leu Ala Leu Glu Gln Asp Leu Glu Phe Gly His 
            340                 345                 350         


Ser Met Val Gln Ala Val Gly Xaa Leu Gln Xaa Gln Xaa Phe Met Gln 
        355                 360                 365             


Pro Leu Xaa Leu Arg Arg Leu Glu His Glu Lys Arg Arg Lys Glu Ile 
    370                 375                 380                 


Lys Glu Ala Trp His Arg Ala Gln Arg Lys Leu Gln Glu Ala Glu Ser 
385                 390                 395                 400 


Asn Leu Arg Lys Ala Lys Gln Gly Tyr Val Gln Arg Cys Glu Asp His 
                405                 410                 415     


Asp Lys Ala Arg Phe Leu Val Ala Lys Ala Glu Glu Glu Gln Ala Gly 
            420                 425                 430         


Ser Ala Pro Gly Ala Gly Ser Xaa Ala Xaa Lys Xaa Leu Asp Lys Arg 
        435                 440                 445             


Arg Arg Leu Glu Glu Glu Ala Lys Asn Lys Ala Glu Glu Ala Met Ala 
    450                 455                 460                 


Xaa Tyr Arg Xaa Cys Val Ala Asp Ala Lys Xaa Gln Lys Gln Glu Leu 
465                 470                 475                 480 


Glu Asp Xaa Lys Val Xaa Ala Leu Arg Gln Ile Gln Glu Val Ile Arg 
                485                 490                 495     


Gln Ser Asp Gln Xaa Ile Lys Ser Ala Xaa Ile Ser Tyr Tyr Gln Met 
            500                 505                 510         


Met His Met Gln Xaa Ala Pro Leu Pro Val His Phe Gln Met Leu Cys 
        515                 520                 525             


Glu Ser Ser Lys Leu Tyr Asp Pro Gly Gln Gln Tyr Ala Ser His Val 
    530                 535                 540                 


Arg Gln Leu Gln Arg Asp Gln Glu Pro Asp Val His Tyr Asp Phe Glu 
545                 550                 555                 560 


Pro His Val Ser Ala Asn Ala Trp Ser Pro Val Met Arg Ala Arg Lys 
                565                 570                 575     


Ser Ser Phe Asn Val Ser Asp Val Ala Arg Pro Glu Ala Ala Gly Ser 
            580                 585                 590         


Pro Pro Glu Glu Gly Gly Cys Xaa Glu Gly Xaa Pro Ala Lys Asp His 
        595                 600                 605             


Arg Ala Gly Arg Gly His Gln Val His Lys Ser Trp Pro Leu Ser Ile 
    610                 615                 620                 


Ser Asp Ser Asp Ser Gly Leu Asp Pro Gly Pro Gly Ala Gly Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Glu Arg Xaa Ser Ser Ser Gly Xaa Met Ser Ser Xaa Glu 
                645                 650                 655     


Glu Leu Val Asp Pro Asp Gly Gly Ala Gly Ala Ser Ala Phe Glu Gln 
            660                 665                 670         


Ala Asp Leu Asn Gly Met Xaa Pro Glu Leu Pro Val Ala Val Pro Ser 
        675                 680                 685             


Gly Pro Phe Arg His Glu Gly Leu Ser Lys Ala Ala Arg Xaa His Arg 
    690                 695                 700                 


Leu Arg Lys Leu Arg Xaa Pro Ala Lys Cys Arg Glu Cys Asn Ser Tyr 
705                 710                 715                 720 


Val Tyr Phe Gln Gly Ala Glu Cys Glu Glu Cys Cys Leu Ala Cys His 
                725                 730                 735     


Lys Lys Cys Leu Glu Xaa Leu Ala Ile Gln Cys Gly His Lys Lys Leu 
            740                 745                 750         


Gln Gly Arg Leu Gln Leu Phe Gly Gln Asp Phe Ser His Ala Ala Arg 
        755                 760                 765             


Ser Ala Pro Asp Gly Val Pro Phe Ile Val Lys Lys Cys Val Cys Glu 
    770                 775                 780                 


Ile Glu Arg Arg Ala Leu Arg Xaa Lys Gly Ile Tyr Arg Val Asn Gly 
785                 790                 795                 800 


Val Lys Xaa Arg Val Glu Lys Leu Cys Gln Ala Phe Glu Asn Gly Lys 
                805                 810                 815     


Glu Leu Val Glu Leu Ser Gln Ala Ser Pro His Asp Ile Ser Asn Val 
            820                 825                 830         


Leu Lys Leu Tyr Leu Arg Gln Leu Pro Glu Pro Leu Ile Ser Phe Arg 
        835                 840                 845             


Leu Tyr His Glu Leu Val Gly Leu Ala Lys Asp Ser Leu Lys Ala Glu 
    850                 855                 860                 


Ala Glu Ala Lys Ala Ala Ser Arg Gly Arg Gln Asp Gly Ser Glu Ser 
865                 870                 875                 880 


Glu Ala Val Ala Val Ala Leu Ala Gly Arg Leu Arg Glu Leu Leu Arg 
                885                 890                 895     


Asp Leu Pro Pro Glu Asn Arg Ala Ser Leu Gln Tyr Leu Leu Arg His 
            900                 905                 910         


Leu Arg Arg Ile Val Glu Val Glu Gln Asp Asn Lys Met Xaa Pro Gly 
        915                 920                 925             


Asn Leu Gly Ile Val Phe Gly Pro Xaa Leu Leu Arg Pro Arg Pro Xaa 
    930                 935                 940                 


Glu Ala Xaa Val Ser Leu Ser Ser Leu Val Asp Tyr Pro His Gln Ala 
945                 950                 955                 960 


Arg Val Ile Glu Xaa Leu Ile Val His Tyr Gly Leu Val Phe Glu Glu 
                965                 970                 975     


Glu Pro Glu Glu Xaa Pro Gly Gly Gln Asp Glu Ser Ser Asn Gln Arg 
            980                 985                 990         


Ala Glu Val Val Val Gln Val Pro  Tyr Leu Glu Ala Gly  Glu Ala Val 
        995                 1000                 1005             


Val Tyr  Pro Leu Gln Glu Ala  Ala Ala Asp Gly Cys  Arg Glu Ser 
    1010                 1015                 1020             


Arg Val  Val Ser Asn Asp Ser  Asp Ser Asp Leu Glu  Glu Ala Ser 
    1025                 1030                 1035             


Glu Leu  Leu Ser Ser Ser Glu  Ala Ser Ala Leu Gly  His Leu Ser 
    1040                 1045                 1050             


Phe Leu  Glu Gln Gln Gln Ser  Glu Ala Ser Leu Glu  Val Ala Ser 
    1055                 1060                 1065             


Gly Ser  His Ser Gly Ser Glu  Glu Gln Leu Glu Ala  Xaa Ala Arg 
    1070                 1075                 1080             


Glu Asp  Gly Asp Gly Asp Glu  Asp Gly Pro Ala Gln  Gln Leu Ser 
    1085                 1090                 1095             


Gly Phe  Asn Xaa Asn Gln Ser  Asn Asn Val Leu Gln  Ala Pro Leu 
    1100                 1105                 1110             


Pro Pro  Met Arg Leu Arg Gly  Gly Arg Met Xaa Leu  Gly Ser Cys 
    1115                 1120                 1125             


Arg Glu  Arg Gln Pro Glu Phe  Val 
    1130                 1135     


<210> 2886
<211> 1163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1108)..(1108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<400> 2886
Met Phe Ser Arg Lys Lys Arg Glu Leu Met Lys Xaa Pro Ser Ile Ser 
1               5                   10                  15      


Lys Lys Asn Arg Ala Gly Ser Pro Ser Pro Gln Pro Ser Gly Pro His 
            20                  25                  30          


Phe Ile Ser Gly Glu Xaa Glu Ala Val Ser Arg Pro Glu Asn Pro Phe 
        35                  40                  45              


Asn Glu Leu Pro Ser Asp Leu Pro Lys Glu Leu Pro Arg Lys Asp Gly 
    50                  55                  60                  


Ala Asp Ala Val Phe Pro Gly Pro Ser Leu Glu Pro Pro Ala Gly Ser 
65                  70                  75                  80  


Ser Gly Val Lys Ala Xaa Gly Xaa Leu Lys Arg Pro Xaa Ser Leu Ser 
                85                  90                  95      


Arg His Ala Ser Ala Ala Gly Phe Pro Leu Ser Gly Ala Ala Ser Trp 
            100                 105                 110         


Xaa Leu Gly Arg Ser His Arg Ser Pro Leu Xaa Ala Ala Ser Pro Gly 
        115                 120                 125             


Glu Leu Pro Xaa Glu Gly Ala Gly Pro Asp Val Val Glu Asp Ile Ser 
    130                 135                 140                 


His Leu Leu Ala Asp Val Ala Arg Phe Ala Glu Gly Leu Glu Lys Leu 
145                 150                 155                 160 


Lys Glu Cys Val Leu Arg Asp Asp Leu Leu Glu Ala Arg Arg Pro Arg 
                165                 170                 175     


Ala His Glu Cys Leu Gly Glu Ala Leu Arg Val Met His Gln Ile Ile 
            180                 185                 190         


Ser Lys Tyr Pro Leu Leu Asn Xaa Val Glu Xaa Leu Xaa Ala Ala Gly 
        195                 200                 205             


Xaa Leu Ile Ala Lys Val Lys Ala Phe His Tyr Glu Ser Asn Asn Asp 
    210                 215                 220                 


Leu Glu Lys Gln Glu Phe Glu Lys Ala Leu Glu Xaa Ile Ala Val Ala 
225                 230                 235                 240 


Phe Ser Ser Xaa Val Ser Glu Phe Leu Met Gly Glu Val Asp Ser Ser 
                245                 250                 255     


Xaa Leu Leu Ala Val Pro Pro Gly Asp Ser Ser Gln Ser Met Glu Ser 
            260                 265                 270         


Leu Tyr Gly Pro Gly Ser Glu Gly Xaa Pro Pro Ser Leu Glu Asp Cys 
        275                 280                 285             


Asp Ala Gly Cys Leu Pro Ala Glu Glu Val Asp Val Leu Leu Gln Arg 
    290                 295                 300                 


Cys Glu Gly Gly Val Asp Ala Ala Leu Leu Tyr Ala Lys Asn Met Ala 
305                 310                 315                 320 


Lys Tyr Met Lys Asp Leu Ile Ser Tyr Leu Glu Lys Arg Xaa Xaa Leu 
                325                 330                 335     


Glu Met Glu Phe Ala Lys Gly Leu Gln Lys Ile Ala His Asn Cys Arg 
            340                 345                 350         


Gln Ser Val Met Gln Glu Pro His Met Pro Leu Leu Ser Ile Tyr Ser 
        355                 360                 365             


Leu Ala Leu Glu Gln Asp Leu Glu Phe Gly His Ser Met Val Gln Ala 
    370                 375                 380                 


Val Gly Xaa Leu Gln Xaa Gln Xaa Phe Met Gln Pro Leu Xaa Leu Arg 
385                 390                 395                 400 


Arg Leu Glu His Glu Lys Arg Arg Lys Glu Ile Lys Glu Ala Trp His 
                405                 410                 415     


Arg Ala Gln Arg Lys Leu Gln Glu Ala Glu Ser Asn Leu Arg Lys Ala 
            420                 425                 430         


Lys Gln Gly Tyr Val Gln Arg Cys Glu Asp His Asp Lys Ala Arg Phe 
        435                 440                 445             


Leu Val Ala Lys Ala Glu Glu Glu Gln Ala Gly Ser Ala Pro Gly Ala 
    450                 455                 460                 


Gly Ser Xaa Ala Xaa Lys Xaa Leu Asp Lys Arg Arg Arg Leu Glu Glu 
465                 470                 475                 480 


Glu Ala Lys Asn Lys Ala Glu Glu Ala Met Ala Xaa Tyr Arg Xaa Cys 
                485                 490                 495     


Val Ala Asp Ala Lys Xaa Gln Lys Gln Glu Leu Glu Asp Xaa Lys Val 
            500                 505                 510         


Xaa Ala Leu Arg Gln Ile Gln Glu Val Ile Arg Gln Ser Asp Gln Xaa 
        515                 520                 525             


Ile Lys Ser Ala Xaa Ile Ser Tyr Tyr Gln Met Met His Met Gln Xaa 
    530                 535                 540                 


Ala Pro Leu Pro Val His Phe Gln Met Leu Cys Glu Ser Ser Lys Leu 
545                 550                 555                 560 


Tyr Asp Pro Gly Gln Gln Tyr Ala Ser His Val Arg Gln Leu Gln Arg 
                565                 570                 575     


Asp Gln Glu Pro Asp Val His Tyr Asp Phe Glu Pro His Val Ser Ala 
            580                 585                 590         


Asn Ala Trp Ser Pro Val Met Arg Ala Arg Lys Ser Ser Phe Asn Val 
        595                 600                 605             


Ser Asp Val Ala Arg Pro Glu Ala Ala Gly Ser Pro Pro Glu Glu Gly 
    610                 615                 620                 


Gly Cys Xaa Glu Gly Xaa Pro Ala Lys Asp His Arg Ala Gly Arg Gly 
625                 630                 635                 640 


His Gln Val His Lys Ser Trp Pro Leu Ser Ile Ser Asp Ser Asp Ser 
                645                 650                 655     


Gly Leu Asp Pro Gly Pro Gly Ala Gly Asp Phe Lys Lys Phe Glu Arg 
            660                 665                 670         


Xaa Ser Ser Ser Gly Xaa Met Ser Ser Xaa Glu Glu Leu Val Asp Pro 
        675                 680                 685             


Asp Gly Gly Ala Gly Ala Ser Ala Phe Glu Gln Ala Asp Leu Asn Gly 
    690                 695                 700                 


Met Xaa Pro Glu Leu Pro Val Ala Val Pro Ser Gly Pro Phe Arg His 
705                 710                 715                 720 


Glu Gly Leu Ser Lys Ala Ala Arg Xaa His Arg Leu Arg Lys Leu Arg 
                725                 730                 735     


Xaa Pro Ala Lys Cys Arg Glu Cys Asn Ser Tyr Val Tyr Phe Gln Gly 
            740                 745                 750         


Ala Glu Cys Glu Glu Cys Cys Leu Ala Cys His Lys Lys Cys Leu Glu 
        755                 760                 765             


Xaa Leu Ala Ile Gln Cys Gly His Lys Lys Leu Gln Gly Arg Leu Gln 
    770                 775                 780                 


Leu Phe Gly Gln Asp Phe Ser His Ala Ala Arg Ser Ala Pro Asp Gly 
785                 790                 795                 800 


Val Pro Phe Ile Val Lys Lys Cys Val Cys Glu Ile Glu Arg Arg Ala 
                805                 810                 815     


Leu Arg Xaa Lys Gly Ile Tyr Arg Val Asn Gly Val Lys Xaa Arg Val 
            820                 825                 830         


Glu Lys Leu Cys Gln Ala Phe Glu Asn Gly Lys Glu Leu Val Glu Leu 
        835                 840                 845             


Ser Gln Ala Ser Pro His Asp Ile Ser Asn Val Leu Lys Leu Tyr Leu 
    850                 855                 860                 


Arg Gln Leu Pro Glu Pro Leu Ile Ser Phe Arg Leu Tyr His Glu Leu 
865                 870                 875                 880 


Val Gly Leu Ala Lys Asp Ser Leu Lys Ala Glu Ala Glu Ala Lys Ala 
                885                 890                 895     


Ala Ser Arg Gly Arg Gln Asp Gly Ser Glu Ser Glu Ala Val Ala Val 
            900                 905                 910         


Ala Leu Ala Gly Arg Leu Arg Glu Leu Leu Arg Asp Leu Pro Pro Glu 
        915                 920                 925             


Asn Arg Ala Ser Leu Gln Tyr Leu Leu Arg His Leu Arg Arg Ile Val 
    930                 935                 940                 


Glu Val Glu Gln Asp Asn Lys Met Xaa Pro Gly Asn Leu Gly Ile Val 
945                 950                 955                 960 


Phe Gly Pro Xaa Leu Leu Arg Pro Arg Pro Xaa Glu Ala Xaa Val Ser 
                965                 970                 975     


Leu Ser Ser Leu Val Asp Tyr Pro His Gln Ala Arg Val Ile Glu Xaa 
            980                 985                 990         


Leu Ile Val His Tyr Gly Leu Val  Phe Glu Glu Glu Pro  Glu Glu Xaa 
        995                 1000                 1005             


Pro Gly  Gly Gln Asp Glu Ser  Ser Asn Gln Arg Ala  Glu Val Val 
    1010                 1015                 1020             


Val Gln  Val Pro Tyr Leu Glu  Ala Gly Glu Ala Val  Val Tyr Pro 
    1025                 1030                 1035             


Leu Gln  Glu Ala Ala Ala Asp  Gly Cys Arg Glu Ser  Arg Val Val 
    1040                 1045                 1050             


Ser Asn  Asp Ser Asp Ser Asp  Leu Glu Glu Ala Ser  Glu Leu Leu 
    1055                 1060                 1065             


Ser Ser  Ser Glu Ala Ser Ala  Leu Gly His Leu Ser  Phe Leu Glu 
    1070                 1075                 1080             


Gln Gln  Gln Ser Glu Ala Ser  Leu Glu Val Ala Ser  Gly Ser His 
    1085                 1090                 1095             


Ser Gly  Ser Glu Glu Gln Leu  Glu Ala Xaa Ala Arg  Glu Asp Gly 
    1100                 1105                 1110             


Asp Gly  Asp Glu Asp Gly Pro  Ala Gln Gln Leu Ser  Gly Phe Asn 
    1115                 1120                 1125             


Xaa Asn  Gln Ser Asn Asn Val  Leu Gln Ala Pro Leu  Pro Pro Met 
    1130                 1135                 1140             


Arg Leu  Arg Gly Gly Arg Met  Xaa Leu Gly Ser Cys  Arg Glu Arg 
    1145                 1150                 1155             


Gln Pro  Glu Phe Val 
    1160             


<210> 2887
<211> 60
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<400> 2887
Met Phe Ser Arg Lys Lys Arg Glu Leu Met Lys Xaa Pro Ser Ile Ser 
1               5                   10                  15      


Lys Lys Asn Arg Ala Gly Ser Pro Ser Pro Gln Pro Ser Gly Xaa Ser 
            20                  25                  30          


Leu Arg Pro Ala Ala Arg Gly Pro Xaa Ser Ala Trp Val Arg Leu Cys 
        35                  40                  45              


Val Ser Cys Ile Arg Ser Ser Pro Ser Xaa Arg Cys 
    50                  55                  60  


<210> 2888
<211> 771
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<400> 2888
Met Gly Val Gly Arg Lys Gly Gly Ala Gly Glu Xaa Glu Ser His Pro 
1               5                   10                  15      


Arg Ile Gly Leu Glu Leu Ala Ser Trp Leu Pro His Pro Gln Gln Glu 
            20                  25                  30          


Ala Glu Ser Asn Leu Arg Lys Ala Lys Gln Gly Tyr Val Gln Arg Cys 
        35                  40                  45              


Glu Asp His Asp Lys Ala Arg Phe Leu Val Ala Lys Ala Glu Glu Glu 
    50                  55                  60                  


Gln Ala Gly Ser Ala Pro Gly Ala Gly Ser Xaa Ala Xaa Lys Xaa Leu 
65                  70                  75                  80  


Asp Lys Arg Arg Arg Leu Glu Glu Glu Ala Lys Asn Lys Ala Glu Glu 
                85                  90                  95      


Ala Met Ala Xaa Tyr Arg Xaa Cys Val Ala Asp Ala Lys Xaa Gln Lys 
            100                 105                 110         


Gln Glu Leu Glu Asp Xaa Lys Val Xaa Ala Leu Arg Gln Ile Gln Glu 
        115                 120                 125             


Val Ile Arg Gln Ser Asp Gln Xaa Ile Lys Ser Ala Xaa Ile Ser Tyr 
    130                 135                 140                 


Tyr Gln Met Met His Met Gln Xaa Ala Pro Leu Pro Val His Phe Gln 
145                 150                 155                 160 


Met Leu Cys Glu Ser Ser Lys Leu Tyr Asp Pro Gly Gln Gln Tyr Ala 
                165                 170                 175     


Ser His Val Arg Gln Leu Gln Arg Asp Gln Glu Pro Asp Val His Tyr 
            180                 185                 190         


Asp Phe Glu Pro His Val Ser Ala Asn Ala Trp Ser Pro Val Met Arg 
        195                 200                 205             


Ala Arg Lys Ser Ser Phe Asn Val Ser Asp Val Ala Arg Pro Glu Ala 
    210                 215                 220                 


Ala Gly Ser Pro Pro Glu Glu Gly Gly Cys Xaa Glu Gly Xaa Pro Ala 
225                 230                 235                 240 


Lys Asp His Arg Ala Gly Arg Gly His Gln Val His Lys Ser Trp Pro 
                245                 250                 255     


Leu Ser Ile Ser Asp Ser Asp Ser Gly Leu Asp Pro Gly Pro Gly Ala 
            260                 265                 270         


Gly Asp Phe Lys Lys Phe Glu Arg Xaa Ser Ser Ser Gly Xaa Met Ser 
        275                 280                 285             


Ser Xaa Glu Glu Leu Val Asp Pro Asp Gly Gly Ala Gly Ala Ser Ala 
    290                 295                 300                 


Phe Glu Gln Ala Asp Leu Asn Gly Met Xaa Pro Glu Leu Pro Val Ala 
305                 310                 315                 320 


Val Pro Ser Gly Pro Phe Arg His Glu Gly Leu Ser Lys Ala Ala Arg 
                325                 330                 335     


Xaa His Arg Leu Arg Lys Leu Arg Xaa Pro Ala Lys Cys Arg Glu Cys 
            340                 345                 350         


Asn Ser Tyr Val Tyr Phe Gln Gly Ala Glu Cys Glu Glu Cys Cys Leu 
        355                 360                 365             


Ala Cys His Lys Lys Cys Leu Glu Xaa Leu Ala Ile Gln Cys Gly His 
    370                 375                 380                 


Lys Lys Leu Gln Gly Arg Leu Gln Leu Phe Gly Gln Asp Phe Ser His 
385                 390                 395                 400 


Ala Ala Arg Ser Ala Pro Asp Gly Val Pro Phe Ile Val Lys Lys Cys 
                405                 410                 415     


Val Cys Glu Ile Glu Arg Arg Ala Leu Arg Xaa Lys Gly Ile Tyr Arg 
            420                 425                 430         


Val Asn Gly Val Lys Xaa Arg Val Glu Lys Leu Cys Gln Ala Phe Glu 
        435                 440                 445             


Asn Gly Lys Glu Leu Val Glu Leu Ser Gln Ala Ser Pro His Asp Ile 
    450                 455                 460                 


Ser Asn Val Leu Lys Leu Tyr Leu Arg Gln Leu Pro Glu Pro Leu Ile 
465                 470                 475                 480 


Ser Phe Arg Leu Tyr His Glu Leu Val Gly Leu Ala Lys Asp Ser Leu 
                485                 490                 495     


Lys Ala Glu Ala Glu Ala Lys Ala Ala Ser Arg Gly Arg Gln Asp Gly 
            500                 505                 510         


Ser Glu Ser Glu Ala Val Ala Val Ala Leu Ala Gly Arg Leu Arg Glu 
        515                 520                 525             


Leu Leu Arg Asp Leu Pro Pro Glu Asn Arg Ala Ser Leu Gln Tyr Leu 
    530                 535                 540                 


Leu Arg His Leu Arg Arg Ile Val Glu Val Glu Gln Asp Asn Lys Met 
545                 550                 555                 560 


Xaa Pro Gly Asn Leu Gly Ile Val Phe Gly Pro Xaa Leu Leu Arg Pro 
                565                 570                 575     


Arg Pro Xaa Glu Ala Xaa Val Ser Leu Ser Ser Leu Val Asp Tyr Pro 
            580                 585                 590         


His Gln Ala Arg Val Ile Glu Xaa Leu Ile Val His Tyr Gly Leu Val 
        595                 600                 605             


Phe Glu Glu Glu Pro Glu Glu Xaa Pro Gly Gly Gln Asp Glu Ser Ser 
    610                 615                 620                 


Asn Gln Arg Ala Glu Val Val Val Gln Val Pro Tyr Leu Glu Ala Gly 
625                 630                 635                 640 


Glu Ala Val Val Tyr Pro Leu Gln Glu Ala Ala Ala Asp Gly Cys Arg 
                645                 650                 655     


Glu Ser Arg Val Val Ser Asn Asp Ser Asp Ser Asp Leu Glu Glu Ala 
            660                 665                 670         


Ser Glu Leu Leu Ser Ser Ser Glu Ala Ser Ala Leu Gly His Leu Ser 
        675                 680                 685             


Phe Leu Glu Gln Gln Gln Ser Glu Ala Ser Leu Glu Val Ala Ser Gly 
    690                 695                 700                 


Ser His Ser Gly Ser Glu Glu Gln Leu Glu Ala Xaa Ala Arg Glu Asp 
705                 710                 715                 720 


Gly Asp Gly Asp Glu Asp Gly Pro Ala Gln Gln Leu Ser Gly Phe Asn 
                725                 730                 735     


Xaa Asn Gln Ser Asn Asn Val Leu Gln Ala Pro Leu Pro Pro Met Arg 
            740                 745                 750         


Leu Arg Gly Gly Arg Met Xaa Leu Gly Ser Cys Arg Glu Arg Gln Pro 
        755                 760                 765             


Glu Phe Val 
    770     


<210> 2889
<211> 1140
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1106)..(1106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1128)..(1128)
<223> Selenocysteine

<400> 2889
Met Leu Gly Arg Arg Leu Gly Ala Arg Ala Ser Tyr Ser Pro Tyr Arg 
1               5                   10                  15      


Ala Gly Arg Gln Gly Pro Gln Gln Arg Gly Arg Asp Pro Gly Ile Gln 
            20                  25                  30          


Leu Xaa Glu Leu Pro Arg Lys Asp Gly Ala Asp Ala Val Phe Pro Gly 
        35                  40                  45              


Pro Ser Leu Glu Pro Pro Ala Gly Ser Ser Gly Val Lys Ala Xaa Gly 
    50                  55                  60                  


Xaa Leu Lys Arg Pro Xaa Ser Leu Ser Arg His Ala Ser Ala Ala Gly 
65                  70                  75                  80  


Phe Pro Leu Ser Gly Ala Ala Ser Trp Xaa Leu Gly Arg Ser His Arg 
                85                  90                  95      


Ser Pro Leu Xaa Ala Ala Ser Pro Gly Glu Leu Pro Xaa Glu Gly Ala 
            100                 105                 110         


Gly Pro Asp Val Val Glu Asp Ile Ser His Leu Leu Ala Asp Val Ala 
        115                 120                 125             


Arg Phe Ala Glu Gly Leu Glu Lys Leu Lys Glu Cys Val Leu Arg Asp 
    130                 135                 140                 


Asp Leu Leu Glu Ala Arg Arg Pro Arg Ala His Glu Cys Leu Gly Glu 
145                 150                 155                 160 


Ala Leu Arg Val Met His Gln Ile Ile Ser Lys Tyr Pro Leu Leu Asn 
                165                 170                 175     


Xaa Val Glu Xaa Leu Xaa Ala Ala Gly Xaa Leu Ile Ala Lys Val Lys 
            180                 185                 190         


Ala Phe His Tyr Glu Ser Asn Asn Asp Leu Glu Lys Gln Glu Phe Glu 
        195                 200                 205             


Lys Ala Leu Glu Xaa Ile Ala Val Ala Phe Ser Ser Xaa Val Ser Glu 
    210                 215                 220                 


Phe Leu Met Gly Glu Val Asp Ser Ser Xaa Leu Leu Ala Val Pro Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Gln Ser Met Glu Ser Leu Tyr Gly Pro Gly Ser Glu 
                245                 250                 255     


Gly Xaa Pro Pro Ser Leu Glu Asp Cys Asp Ala Gly Cys Leu Pro Ala 
            260                 265                 270         


Glu Glu Val Asp Val Leu Leu Gln Arg Cys Glu Gly Gly Val Asp Ala 
        275                 280                 285             


Ala Leu Leu Tyr Ala Lys Asn Met Ala Lys Tyr Met Lys Asp Leu Ile 
    290                 295                 300                 


Ser Tyr Leu Glu Lys Arg Xaa Xaa Leu Glu Met Glu Phe Ala Lys Gly 
305                 310                 315                 320 


Leu Gln Lys Ile Ala His Asn Cys Arg Gln Ser Val Met Gln Glu Pro 
                325                 330                 335     


His Met Pro Leu Leu Ser Ile Tyr Ser Leu Ala Leu Glu Gln Asp Leu 
            340                 345                 350         


Glu Phe Gly His Ser Met Val Gln Ala Val Gly Xaa Leu Gln Xaa Gln 
        355                 360                 365             


Xaa Phe Met Gln Pro Leu Xaa Leu Arg Arg Leu Glu His Glu Lys Arg 
    370                 375                 380                 


Arg Lys Glu Ile Lys Glu Ala Trp His Arg Ala Gln Arg Lys Leu Gln 
385                 390                 395                 400 


Glu Ala Glu Ser Asn Leu Arg Lys Ala Lys Gln Gly Tyr Val Gln Arg 
                405                 410                 415     


Cys Glu Asp His Asp Lys Ala Arg Phe Leu Val Ala Lys Ala Glu Glu 
            420                 425                 430         


Glu Gln Ala Gly Ser Ala Pro Gly Ala Gly Ser Xaa Ala Xaa Lys Xaa 
        435                 440                 445             


Leu Asp Lys Arg Arg Arg Leu Glu Glu Glu Ala Lys Asn Lys Ala Glu 
    450                 455                 460                 


Glu Ala Met Ala Xaa Tyr Arg Xaa Cys Val Ala Asp Ala Lys Xaa Gln 
465                 470                 475                 480 


Lys Gln Glu Leu Glu Asp Xaa Lys Val Xaa Ala Leu Arg Gln Ile Gln 
                485                 490                 495     


Glu Val Ile Arg Gln Ser Asp Gln Xaa Ile Lys Ser Ala Xaa Ile Ser 
            500                 505                 510         


Tyr Tyr Gln Met Met His Met Gln Xaa Ala Pro Leu Pro Val His Phe 
        515                 520                 525             


Gln Met Leu Cys Glu Ser Ser Lys Leu Tyr Asp Pro Gly Gln Gln Tyr 
    530                 535                 540                 


Ala Ser His Val Arg Gln Leu Gln Arg Asp Gln Glu Pro Asp Val His 
545                 550                 555                 560 


Tyr Asp Phe Glu Pro His Val Ser Ala Asn Ala Trp Ser Pro Val Met 
                565                 570                 575     


Arg Ala Arg Lys Ser Ser Phe Asn Val Ser Asp Val Ala Arg Pro Glu 
            580                 585                 590         


Ala Ala Gly Ser Pro Pro Glu Glu Gly Gly Cys Xaa Glu Gly Xaa Pro 
        595                 600                 605             


Ala Lys Asp His Arg Ala Gly Arg Gly His Gln Val His Lys Ser Trp 
    610                 615                 620                 


Pro Leu Ser Ile Ser Asp Ser Asp Ser Gly Leu Asp Pro Gly Pro Gly 
625                 630                 635                 640 


Ala Gly Asp Phe Lys Lys Phe Glu Arg Xaa Ser Ser Ser Gly Xaa Met 
                645                 650                 655     


Ser Ser Xaa Glu Glu Leu Val Asp Pro Asp Gly Gly Ala Gly Ala Ser 
            660                 665                 670         


Ala Phe Glu Gln Ala Asp Leu Asn Gly Met Xaa Pro Glu Leu Pro Val 
        675                 680                 685             


Ala Val Pro Ser Gly Pro Phe Arg His Glu Gly Leu Ser Lys Ala Ala 
    690                 695                 700                 


Arg Xaa His Arg Leu Arg Lys Leu Arg Xaa Pro Ala Lys Cys Arg Glu 
705                 710                 715                 720 


Cys Asn Ser Tyr Val Tyr Phe Gln Gly Ala Glu Cys Glu Glu Cys Cys 
                725                 730                 735     


Leu Ala Cys His Lys Lys Cys Leu Glu Xaa Leu Ala Ile Gln Cys Gly 
            740                 745                 750         


His Lys Lys Leu Gln Gly Arg Leu Gln Leu Phe Gly Gln Asp Phe Ser 
        755                 760                 765             


His Ala Ala Arg Ser Ala Pro Asp Gly Val Pro Phe Ile Val Lys Lys 
    770                 775                 780                 


Cys Val Cys Glu Ile Glu Arg Arg Ala Leu Arg Xaa Lys Gly Ile Tyr 
785                 790                 795                 800 


Arg Val Asn Gly Val Lys Xaa Arg Val Glu Lys Leu Cys Gln Ala Phe 
                805                 810                 815     


Glu Asn Gly Lys Glu Leu Val Glu Leu Ser Gln Ala Ser Pro His Asp 
            820                 825                 830         


Ile Ser Asn Val Leu Lys Leu Tyr Leu Arg Gln Leu Pro Glu Pro Leu 
        835                 840                 845             


Ile Ser Phe Arg Leu Tyr His Glu Leu Val Gly Leu Ala Lys Asp Ser 
    850                 855                 860                 


Leu Lys Ala Glu Ala Glu Ala Lys Ala Ala Ser Arg Gly Arg Gln Asp 
865                 870                 875                 880 


Gly Ser Glu Ser Glu Ala Val Ala Val Ala Leu Ala Gly Arg Leu Arg 
                885                 890                 895     


Glu Leu Leu Arg Asp Leu Pro Pro Glu Asn Arg Ala Ser Leu Gln Tyr 
            900                 905                 910         


Leu Leu Arg His Leu Arg Arg Ile Val Glu Val Glu Gln Asp Asn Lys 
        915                 920                 925             


Met Xaa Pro Gly Asn Leu Gly Ile Val Phe Gly Pro Xaa Leu Leu Arg 
    930                 935                 940                 


Pro Arg Pro Xaa Glu Ala Xaa Val Ser Leu Ser Ser Leu Val Asp Tyr 
945                 950                 955                 960 


Pro His Gln Ala Arg Val Ile Glu Xaa Leu Ile Val His Tyr Gly Leu 
                965                 970                 975     


Val Phe Glu Glu Glu Pro Glu Glu Xaa Pro Gly Gly Gln Asp Glu Ser 
            980                 985                 990         


Ser Asn Gln Arg Ala Glu Val Val  Val Gln Val Pro Tyr  Leu Glu Ala 
        995                 1000                 1005             


Gly Glu  Ala Val Val Tyr Pro  Leu Gln Glu Ala Ala  Ala Asp Gly 
    1010                 1015                 1020             


Cys Arg  Glu Ser Arg Val Val  Ser Asn Asp Ser Asp  Ser Asp Leu 
    1025                 1030                 1035             


Glu Glu  Ala Ser Glu Leu Leu  Ser Ser Ser Glu Ala  Ser Ala Leu 
    1040                 1045                 1050             


Gly His  Leu Ser Phe Leu Glu  Gln Gln Gln Ser Glu  Ala Ser Leu 
    1055                 1060                 1065             


Glu Val  Ala Ser Gly Ser His  Ser Gly Ser Glu Glu  Gln Leu Glu 
    1070                 1075                 1080             


Ala Xaa  Ala Arg Glu Asp Gly  Asp Gly Asp Glu Asp  Gly Pro Ala 
    1085                 1090                 1095             


Gln Gln  Leu Ser Gly Phe Asn  Xaa Asn Gln Ser Asn  Asn Val Leu 
    1100                 1105                 1110             


Gln Ala  Pro Leu Pro Pro Met  Arg Leu Arg Gly Gly  Arg Met Xaa 
    1115                 1120                 1125             


Leu Gly  Ser Cys Arg Glu Arg  Gln Pro Glu Phe Val  
    1130                 1135                 1140 


<210> 2890
<211> 1152
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<400> 2890
Met Ser Arg Gly Gln Arg Val Leu Lys Gly Leu Leu Gly Trp Val Cys 
1               5                   10                  15      


Xaa Trp Xaa Trp Ala Trp Arg Ala Arg Leu Gly Ala Arg Gly Cys Gly 
            20                  25                  30          


Leu His Val Leu Cys Pro Arg Asp Leu Pro Leu Pro Pro Glu Glu Leu 
        35                  40                  45              


Pro Arg Lys Asp Gly Ala Asp Ala Val Phe Pro Gly Pro Ser Leu Glu 
    50                  55                  60                  


Pro Pro Ala Gly Ser Ser Gly Val Lys Ala Xaa Gly Xaa Leu Lys Arg 
65                  70                  75                  80  


Pro Xaa Ser Leu Ser Arg His Ala Ser Ala Ala Gly Phe Pro Leu Ser 
                85                  90                  95      


Gly Ala Ala Ser Trp Xaa Leu Gly Arg Ser His Arg Ser Pro Leu Xaa 
            100                 105                 110         


Ala Ala Ser Pro Gly Glu Leu Pro Xaa Glu Gly Ala Gly Pro Asp Val 
        115                 120                 125             


Val Glu Asp Ile Ser His Leu Leu Ala Asp Val Ala Arg Phe Ala Glu 
    130                 135                 140                 


Gly Leu Glu Lys Leu Lys Glu Cys Val Leu Arg Asp Asp Leu Leu Glu 
145                 150                 155                 160 


Ala Arg Arg Pro Arg Ala His Glu Cys Leu Gly Glu Ala Leu Arg Val 
                165                 170                 175     


Met His Gln Ile Ile Ser Lys Tyr Pro Leu Leu Asn Xaa Val Glu Xaa 
            180                 185                 190         


Leu Xaa Ala Ala Gly Xaa Leu Ile Ala Lys Val Lys Ala Phe His Tyr 
        195                 200                 205             


Glu Ser Asn Asn Asp Leu Glu Lys Gln Glu Phe Glu Lys Ala Leu Glu 
    210                 215                 220                 


Xaa Ile Ala Val Ala Phe Ser Ser Xaa Val Ser Glu Phe Leu Met Gly 
225                 230                 235                 240 


Glu Val Asp Ser Ser Xaa Leu Leu Ala Val Pro Pro Gly Asp Ser Ser 
                245                 250                 255     


Gln Ser Met Glu Ser Leu Tyr Gly Pro Gly Ser Glu Gly Xaa Pro Pro 
            260                 265                 270         


Ser Leu Glu Asp Cys Asp Ala Gly Cys Leu Pro Ala Glu Glu Val Asp 
        275                 280                 285             


Val Leu Leu Gln Arg Cys Glu Gly Gly Val Asp Ala Ala Leu Leu Tyr 
    290                 295                 300                 


Ala Lys Asn Met Ala Lys Tyr Met Lys Asp Leu Ile Ser Tyr Leu Glu 
305                 310                 315                 320 


Lys Arg Xaa Xaa Leu Glu Met Glu Phe Ala Lys Gly Leu Gln Lys Ile 
                325                 330                 335     


Ala His Asn Cys Arg Gln Ser Val Met Gln Glu Pro His Met Pro Leu 
            340                 345                 350         


Leu Ser Ile Tyr Ser Leu Ala Leu Glu Gln Asp Leu Glu Phe Gly His 
        355                 360                 365             


Ser Met Val Gln Ala Val Gly Xaa Leu Gln Xaa Gln Xaa Phe Met Gln 
    370                 375                 380                 


Pro Leu Xaa Leu Arg Arg Leu Glu His Glu Lys Arg Arg Lys Glu Ile 
385                 390                 395                 400 


Lys Glu Ala Trp His Arg Ala Gln Arg Lys Leu Gln Glu Ala Glu Ser 
                405                 410                 415     


Asn Leu Arg Lys Ala Lys Gln Gly Tyr Val Gln Arg Cys Glu Asp His 
            420                 425                 430         


Asp Lys Ala Arg Phe Leu Val Ala Lys Ala Glu Glu Glu Gln Ala Gly 
        435                 440                 445             


Ser Ala Pro Gly Ala Gly Ser Xaa Ala Xaa Lys Xaa Leu Asp Lys Arg 
    450                 455                 460                 


Arg Arg Leu Glu Glu Glu Ala Lys Asn Lys Ala Glu Glu Ala Met Ala 
465                 470                 475                 480 


Xaa Tyr Arg Xaa Cys Val Ala Asp Ala Lys Xaa Gln Lys Gln Glu Leu 
                485                 490                 495     


Glu Asp Xaa Lys Val Xaa Ala Leu Arg Gln Ile Gln Glu Val Ile Arg 
            500                 505                 510         


Gln Ser Asp Gln Xaa Ile Lys Ser Ala Xaa Ile Ser Tyr Tyr Gln Met 
        515                 520                 525             


Met His Met Gln Xaa Ala Pro Leu Pro Val His Phe Gln Met Leu Cys 
    530                 535                 540                 


Glu Ser Ser Lys Leu Tyr Asp Pro Gly Gln Gln Tyr Ala Ser His Val 
545                 550                 555                 560 


Arg Gln Leu Gln Arg Asp Gln Glu Pro Asp Val His Tyr Asp Phe Glu 
                565                 570                 575     


Pro His Val Ser Ala Asn Ala Trp Ser Pro Val Met Arg Ala Arg Lys 
            580                 585                 590         


Ser Ser Phe Asn Val Ser Asp Val Ala Arg Pro Glu Ala Ala Gly Ser 
        595                 600                 605             


Pro Pro Glu Glu Gly Gly Cys Xaa Glu Gly Xaa Pro Ala Lys Asp His 
    610                 615                 620                 


Arg Ala Gly Arg Gly His Gln Val His Lys Ser Trp Pro Leu Ser Ile 
625                 630                 635                 640 


Ser Asp Ser Asp Ser Gly Leu Asp Pro Gly Pro Gly Ala Gly Asp Phe 
                645                 650                 655     


Lys Lys Phe Glu Arg Xaa Ser Ser Ser Gly Xaa Met Ser Ser Xaa Glu 
            660                 665                 670         


Glu Leu Val Asp Pro Asp Gly Gly Ala Gly Ala Ser Ala Phe Glu Gln 
        675                 680                 685             


Ala Asp Leu Asn Gly Met Xaa Pro Glu Leu Pro Val Ala Val Pro Ser 
    690                 695                 700                 


Gly Pro Phe Arg His Glu Gly Leu Ser Lys Ala Ala Arg Xaa His Arg 
705                 710                 715                 720 


Leu Arg Lys Leu Arg Xaa Pro Ala Lys Cys Arg Glu Cys Asn Ser Tyr 
                725                 730                 735     


Val Tyr Phe Gln Gly Ala Glu Cys Glu Glu Cys Cys Leu Ala Cys His 
            740                 745                 750         


Lys Lys Cys Leu Glu Xaa Leu Ala Ile Gln Cys Gly His Lys Lys Leu 
        755                 760                 765             


Gln Gly Arg Leu Gln Leu Phe Gly Gln Asp Phe Ser His Ala Ala Arg 
    770                 775                 780                 


Ser Ala Pro Asp Gly Val Pro Phe Ile Val Lys Lys Cys Val Cys Glu 
785                 790                 795                 800 


Ile Glu Arg Arg Ala Leu Arg Xaa Lys Gly Ile Tyr Arg Val Asn Gly 
                805                 810                 815     


Val Lys Xaa Arg Val Glu Lys Leu Cys Gln Ala Phe Glu Asn Gly Lys 
            820                 825                 830         


Glu Leu Val Glu Leu Ser Gln Ala Ser Pro His Asp Ile Ser Asn Val 
        835                 840                 845             


Leu Lys Leu Tyr Leu Arg Gln Leu Pro Glu Pro Leu Ile Ser Phe Arg 
    850                 855                 860                 


Leu Tyr His Glu Leu Val Gly Leu Ala Lys Asp Ser Leu Lys Ala Glu 
865                 870                 875                 880 


Ala Glu Ala Lys Ala Ala Ser Arg Gly Arg Gln Asp Gly Ser Glu Ser 
                885                 890                 895     


Glu Ala Val Ala Val Ala Leu Ala Gly Arg Leu Arg Glu Leu Leu Arg 
            900                 905                 910         


Asp Leu Pro Pro Glu Asn Arg Ala Ser Leu Gln Tyr Leu Leu Arg His 
        915                 920                 925             


Leu Arg Arg Ile Val Glu Val Glu Gln Asp Asn Lys Met Xaa Pro Gly 
    930                 935                 940                 


Asn Leu Gly Ile Val Phe Gly Pro Xaa Leu Leu Arg Pro Arg Pro Xaa 
945                 950                 955                 960 


Glu Ala Xaa Val Ser Leu Ser Ser Leu Val Asp Tyr Pro His Gln Ala 
                965                 970                 975     


Arg Val Ile Glu Xaa Leu Ile Val His Tyr Gly Leu Val Phe Glu Glu 
            980                 985                 990         


Glu Pro Glu Glu Xaa Pro Gly Gly  Gln Asp Glu Ser Ser  Asn Gln Arg 
        995                 1000                 1005             


Ala Glu  Val Val Val Gln Val  Pro Tyr Leu Glu Ala  Gly Glu Ala 
    1010                 1015                 1020             


Val Val  Tyr Pro Leu Gln Glu  Ala Ala Ala Asp Gly  Cys Arg Glu 
    1025                 1030                 1035             


Ser Arg  Val Val Ser Asn Asp  Ser Asp Ser Asp Leu  Glu Glu Ala 
    1040                 1045                 1050             


Ser Glu  Leu Leu Ser Ser Ser  Glu Ala Ser Ala Leu  Gly His Leu 
    1055                 1060                 1065             


Ser Phe  Leu Glu Gln Gln Gln  Ser Glu Ala Ser Leu  Glu Val Ala 
    1070                 1075                 1080             


Ser Gly  Ser His Ser Gly Ser  Glu Glu Gln Leu Glu  Ala Xaa Ala 
    1085                 1090                 1095             


Arg Glu  Asp Gly Asp Gly Asp  Glu Asp Gly Pro Ala  Gln Gln Leu 
    1100                 1105                 1110             


Ser Gly  Phe Asn Xaa Asn Gln  Ser Asn Asn Val Leu  Gln Ala Pro 
    1115                 1120                 1125             


Leu Pro  Pro Met Arg Leu Arg  Gly Gly Arg Met Xaa  Leu Gly Ser 
    1130                 1135                 1140             


Cys Arg  Glu Arg Gln Pro Glu  Phe Val 
    1145                 1150         


<210> 2891
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 2891
Met Val Gly Ser Xaa Pro His Phe Gly Asp Pro Cys Ala Gly Ser Pro 
1               5                   10                  15      


Gly Pro Gly Gly Arg Gly Asp Pro Asp Gly Arg Gly Asp Pro Asp Gly 
            20                  25                  30          


Gln Gly Pro Glu Leu Pro Arg Lys Asp Gly Ala Asp Ala Val Phe Pro 
        35                  40                  45              


Gly Pro Ser Leu Glu Pro Pro Ala Gly Ser Ser Gly Val Lys Ala Xaa 
    50                  55                  60                  


Gly Xaa Leu Lys Arg Pro Xaa Ser Leu Ser Arg His Ala Ser Ala Ala 
65                  70                  75                  80  


Gly Phe Pro Leu Ser Gly Ala Ala Ser Trp Xaa Leu Gly Arg Ser His 
                85                  90                  95      


Arg Ser Pro Leu Xaa Ala Ala Ser Pro Gly Glu Leu Pro Xaa Glu Gly 
            100                 105                 110         


Ala Gly Pro Asp Val Val Glu Asp Ile Ser His Leu Leu Ala Asp Val 
        115                 120                 125             


Ala Arg Phe Ala Glu Gly Leu Glu Lys Leu Lys Glu Cys Val Leu Arg 
    130                 135                 140                 


Asp Asp Leu Leu Glu Ala Arg Arg Pro Arg Ala His Glu Cys Leu Gly 
145                 150                 155                 160 


Glu Ala Leu Arg Val Met His Gln Ile Ile 
                165                 170 


<210> 2892
<211> 37
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<400> 2892
Met Met Ala Lys Asn Lys Glu Pro Arg Pro Pro Ser Tyr Xaa Ile Ser 
1               5                   10                  15      


Ile Val Gly Leu Ser Gly Xaa Glu Lys Asp Lys Gly Asn Cys Gly Val 
            20                  25                  30          


Gly Lys Ser Cys Leu 
        35          


<210> 2893
<211> 140
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<400> 2893
Met Met Ala Lys Asn Lys Glu Pro Arg Pro Pro Ser Tyr Xaa Ile Ser 
1               5                   10                  15      


Ile Val Gly Leu Ser Gly Xaa Glu Lys Asp Lys Gly Asn Cys Gly Val 
            20                  25                  30          


Gly Lys Ser Cys Leu Cys Asn Arg Phe Val Arg Ser Lys Ala Asp Glu 
        35                  40                  45              


Tyr Tyr Pro Glu His Xaa Ser Val Leu Ser Xaa Ile Asp Phe Gly Gly 
    50                  55                  60                  


Arg Val Val Asn Asn Asp His Phe Leu Tyr Trp Gly Asp Ile Ile Gln 
65                  70                  75                  80  


Asn Ser Glu Asp Gly Val Glu Cys Lys Ile His Val Ile Glu Gln Xaa 
                85                  90                  95      


Glu Phe Ile Asp Asp Gln Xaa Phe Leu Pro His Arg Ser Xaa Asn Leu 
            100                 105                 110         


Gln Pro Tyr Ile Lys Arg Ala Ala Ala Ser Lys Leu Gln Ser Ala Glu 
        115                 120                 125             


Lys Leu Met Tyr Ile Cys Xaa Asp Gln Leu Gly Leu 
    130                 135                 140 


<210> 2894
<211> 1498
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1248)..(1248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1300)..(1300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1323)..(1323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1361)..(1361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1387)..(1387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1402)..(1402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1413)..(1413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1426)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1436)..(1436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1453)..(1454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1492)..(1492)
<223> Selenocysteine

<400> 2894
Met Met Ala Lys Asn Lys Glu Pro Arg Pro Pro Ser Tyr Xaa Ile Ser 
1               5                   10                  15      


Ile Val Gly Leu Ser Gly Xaa Glu Lys Asp Lys Gly Asn Cys Gly Val 
            20                  25                  30          


Gly Lys Ser Cys Leu Cys Asn Arg Phe Val Arg Ser Lys Ala Asp Glu 
        35                  40                  45              


Tyr Tyr Pro Glu His Xaa Ser Val Leu Ser Xaa Ile Asp Phe Gly Gly 
    50                  55                  60                  


Arg Val Val Asn Asn Asp His Phe Leu Tyr Trp Gly Asp Ile Ile Gln 
65                  70                  75                  80  


Asn Ser Glu Asp Gly Val Glu Cys Lys Ile His Val Ile Glu Gln Xaa 
                85                  90                  95      


Glu Phe Ile Asp Asp Gln Xaa Phe Leu Pro His Arg Ser Xaa Asn Leu 
            100                 105                 110         


Gln Pro Tyr Ile Lys Arg Ala Ala Ala Ser Lys Leu Gln Ser Ala Glu 
        115                 120                 125             


Lys Leu Met Tyr Ile Cys Xaa Asp Gln Leu Gly Leu Glu Gln Asp Phe 
    130                 135                 140                 


Glu Gln Lys Gln Met Pro Glu Gly Lys Leu Asn Val Asp Gly Phe Leu 
145                 150                 155                 160 


Leu Cys Ile Asp Val Ser Gln Gly Cys Asn Arg Lys Phe Asp Asp Gln 
                165                 170                 175     


Leu Lys Phe Val Asn Asn Leu Phe Val Gln Leu Ser Lys Ser Lys Lys 
            180                 185                 190         


Pro Val Ile Ile Ala Ala Xaa Lys Cys Asp Glu Cys Val Asp His Tyr 
        195                 200                 205             


Leu Arg Glu Val Gln Ala Phe Ala Ser Asn Lys Lys Asn Leu Leu Val 
    210                 215                 220                 


Val Glu Xaa Ser Ala Arg Phe Asn Val Asn Ile Glu Xaa Cys Phe Xaa 
225                 230                 235                 240 


Ala Leu Val Gln Met Leu Asp Lys Xaa Arg Ser Lys Pro Lys Ile Ile 
                245                 250                 255     


Pro Tyr Leu Asp Ala Tyr Lys Xaa Gln Arg Gln Leu Val Val Xaa Ala 
            260                 265                 270         


Xaa Asp Lys Phe Glu Lys Leu Val Gln Xaa Val Arg Asp Tyr His Ala 
        275                 280                 285             


Xaa Trp Lys Xaa Val Ser Asn Lys Leu Lys Asn His Pro Asp Tyr Glu 
    290                 295                 300                 


Glu Tyr Ile Asn Leu Glu Gly Xaa Arg Lys Ala Arg Asn Xaa Phe Ser 
305                 310                 315                 320 


Lys His Ile Glu Gln Leu Lys Gln Glu His Ile Arg Lys Arg Arg Glu 
                325                 330                 335     


Glu Tyr Ile Asn Xaa Leu Pro Arg Ala Phe Asn Xaa Leu Leu Pro Asn 
            340                 345                 350         


Leu Glu Glu Ile Glu His Leu Asn Trp Ser Glu Ala Leu Lys Leu Met 
        355                 360                 365             


Glu Lys Arg Ala Asp Phe Gln Leu Cys Phe Val Val Leu Glu Lys Xaa 
    370                 375                 380                 


Pro Trp Asp Glu Xaa Asp His Ile Asp Lys Ile Asn Asp Arg Arg Ile 
385                 390                 395                 400 


Pro Phe Asp Leu Leu Ser Xaa Leu Glu Ala Glu Lys Val Tyr Gln Asn 
                405                 410                 415     


His Val Gln His Leu Ile Ser Glu Lys Arg Arg Val Glu Met Lys Glu 
            420                 425                 430         


Lys Phe Lys Lys Xaa Leu Glu Lys Ile Gln Phe Ile Ser Pro Gly Gln 
        435                 440                 445             


Pro Trp Glu Glu Val Met Cys Phe Val Met Glu Asp Glu Ala Tyr Lys 
    450                 455                 460                 


Tyr Ile Xaa Glu Ala Asp Ser Lys Glu Val Tyr Gly Arg His Gln Arg 
465                 470                 475                 480 


Glu Ile Val Glu Lys Ala Lys Glu Glu Phe Gln Glu Met Leu Phe Glu 
                485                 490                 495     


His Ser Glu Leu Phe Tyr Asp Leu Asp Leu Asn Ala Xaa Pro Ser Ser 
            500                 505                 510         


Asp Lys Met Ser Glu Ile His Xaa Val Leu Ser Glu Glu Pro Arg Tyr 
        515                 520                 525             


Lys Ala Leu Gln Lys Leu Ala Pro Asp Arg Glu Ser Leu Leu Leu Lys 
    530                 535                 540                 


His Ile Gly Phe Val Tyr His Pro Xaa Lys Glu Xaa Cys Leu Ser Gly 
545                 550                 555                 560 


Gln Asn Cys Xaa Asp Ile Lys Val Glu Gln Leu Leu Ala Ser Ser Leu 
                565                 570                 575     


Leu Gln Leu Asp His Gly Arg Leu Arg Leu Tyr His Asp Ser Xaa Asn 
            580                 585                 590         


Ile Asp Lys Val Asn Leu Phe Ile Leu Gly Lys Asp Gly Leu Ala Gln 
        595                 600                 605             


Glu Leu Ala Asn Glu Ile Arg Xaa Gln Ser Xaa Asp Asp Glu Tyr Ala 
    610                 615                 620                 


Leu Asp Gly Lys Ile Tyr Glu Leu Asp Leu Arg Pro Val Asp Ala Lys 
625                 630                 635                 640 


Ser Pro Tyr Phe Leu Ser Gln Leu Trp Xaa Ala Ala Phe Lys Pro His 
                645                 650                 655     


Gly Cys Phe Cys Val Phe Asn Ser Ile Glu Ser Leu Ser Phe Ile Gly 
            660                 665                 670         


Glu Phe Ile Gly Lys Ile Arg Xaa Glu Ala Ser Gln Ile Arg Lys Asp 
        675                 680                 685             


Lys Tyr Met Ala Asn Leu Pro Phe Xaa Leu Ile Leu Ala Asn Gln Arg 
    690                 695                 700                 


Asp Ser Ile Ser Lys Asn Leu Pro Ile Leu Arg His Gln Gly Gln Gln 
705                 710                 715                 720 


Leu Ala Asn Lys Leu Gln Cys Pro Phe Val Asp Val Pro Ala Gly Xaa 
                725                 730                 735     


Tyr Pro Arg Lys Phe Asn Glu Xaa Gln Ile Lys Gln Ala Leu Arg Gly 
            740                 745                 750         


Val Leu Glu Ser Val Lys His Asn Leu Asp Val Val Ser Pro Ile Pro 
        755                 760                 765             


Ala Asn Lys Asp Leu Ser Glu Ala Asp Leu Arg Ile Val Met Cys Ala 
    770                 775                 780                 


Met Cys Gly Asp Pro Phe Ser Val Asp Leu Ile Leu Ser Pro Phe Leu 
785                 790                 795                 800 


Asp Ser His Ser Cys Ser Ala Ala Gln Ala Gly Gln Asn Asn Ser Leu 
                805                 810                 815     


Met Leu Asp Lys Ile Ile Gly Glu Lys Arg Arg Arg Ile Gln Ile Xaa 
            820                 825                 830         


Ile Leu Ser Tyr His Ser Ser Ile Gly Val Arg Lys Asp Glu Leu Val 
        835                 840                 845             


His Gly Tyr Ile Leu Val Tyr Ser Ala Lys Arg Lys Ala Ser Met Gly 
    850                 855                 860                 


Met Leu Arg Ala Phe Leu Ser Glu Val Gln Asp Xaa Ile Pro Val Gln 
865                 870                 875                 880 


Leu Val Ala Val Xaa Asp Ser Gln Ala Asp Phe Phe Glu Asn Glu Ala 
                885                 890                 895     


Ile Lys Glu Leu Met Xaa Glu Gly Glu His Ile Ala Xaa Glu Ile Xaa 
            900                 905                 910         


Ala Lys Phe Xaa Ala Leu Tyr Ser Leu Ser Gln Tyr His Arg Gln Xaa 
        915                 920                 925             


Glu Val Phe Xaa Leu Phe Phe Ser Asp Val Leu Glu Lys Lys Asn Met 
    930                 935                 940                 


Ile Glu Asn Ser Tyr Leu Ser Asp Asn Xaa Arg Glu Ser Xaa His Gln 
945                 950                 955                 960 


Ser Glu Asp Val Phe Leu Pro Ser Pro Arg Asp Cys Phe Pro Tyr Asn 
                965                 970                 975     


Asn Tyr Pro Asp Ser Asp Asp Asp Xaa Glu Ala Pro Pro Pro Tyr Ser 
            980                 985                 990         


Pro Ile Gly Asp Asp Val Gln Leu  Leu Pro Xaa Pro Ser  Asp Arg Ser 
        995                 1000                 1005             


Arg Tyr  Arg Leu Asp Leu Glu  Gly Asn Glu Tyr Pro  Ile His Ser 
    1010                 1015                 1020             


Xaa Pro  Asn Cys His Asp His  Glu Arg Asn His Lys  Val Pro Pro 
    1025                 1030                 1035             


Pro Ile  Lys Pro Lys Pro Val  Val Pro Lys Xaa Asn  Val Lys Lys 
    1040                 1045                 1050             


Leu Asp  Pro Asn Leu Leu Lys  Xaa Ile Glu Ala Gly  Ile Gly Lys 
    1055                 1060                 1065             


Asn Pro  Arg Lys Gln Xaa Ser  Arg Val Pro Leu Ala  His Pro Glu 
    1070                 1075                 1080             


Asp Met  Asp Pro Ser Asp Asn  Tyr Ala Glu Pro Ile  Asp Xaa Ile 
    1085                 1090                 1095             


Phe Lys  Gln Lys Gly Tyr Ser  Asp Glu Ile Tyr Val  Val Pro Asp 
    1100                 1105                 1110             


Asp Ser  Gln Asn Arg Ile Lys  Ile Arg Asn Ser Phe  Val Asn Asn 
    1115                 1120                 1125             


Xaa Gln  Gly Asp Glu Glu Asn  Gly Phe Ser Asp Arg  Pro Gln Lys 
    1130                 1135                 1140             


Val Met  Gly Asn Gly Gly Leu  Gln Asn Xaa Asn Ile  Asn Leu Lys 
    1145                 1150                 1155             


Pro Cys  Leu Val Lys Pro Ser  His Xaa Ile Glu Glu  His Ile Gln 
    1160                 1165                 1170             


Met Pro  Val Met Met Arg Leu  Ser Pro Leu Leu Lys  Gln Arg Lys 
    1175                 1180                 1185             


Gly Arg  His Arg Gly Ser Glu  Glu Asp Pro Leu Leu  Ser Pro Val 
    1190                 1195                 1200             


Glu Xaa  Trp Lys Gly Gly Ile  Asp Asn Pro Ala Ile  Xaa Ser Asp 
    1205                 1210                 1215             


Gln Glu  Leu Asp Asp Lys Lys  Met Lys Lys Lys Xaa  His Lys Val 
    1220                 1225                 1230             


Lys Glu  Asp Lys Lys Lys Lys  Xaa Lys Asn Phe Asn  Pro Pro Xaa 
    1235                 1240                 1245             


Arg Arg  Asn Trp Glu Ser Asn  Tyr Phe Gly Met Pro  Leu Gln Asp 
    1250                 1255                 1260             


Leu Val  Xaa Ala Glu Lys Pro  Ile Pro Leu Phe Val  Glu Lys Cys 
    1265                 1270                 1275             


Val Glu  Phe Ile Glu Asp Xaa  Gly Leu Cys Xaa Glu  Gly Leu Tyr 
    1280                 1285                 1290             


Arg Val  Ser Gly Asn Lys Xaa  Asp Gln Asp Asn Ile  Gln Lys Gln 
    1295                 1300                 1305             


Phe Asp  Gln Asp His Asn Ile  Asn Leu Val Ser Met  Glu Val Xaa 
    1310                 1315                 1320             


Val Asn  Ala Val Ala Gly Ala  Leu Lys Ala Phe Phe  Ala Asp Leu 
    1325                 1330                 1335             


Pro Asp  Pro Leu Ile Pro Tyr  Ser Leu His Pro Glu  Leu Leu Glu 
    1340                 1345                 1350             


Ala Ala  Lys Ile Pro Asp Lys  Xaa Glu Arg Leu His  Ala Leu Lys 
    1355                 1360                 1365             


Glu Ile  Val Lys Lys Phe His  Pro Val Asn Tyr Asp  Val Phe Arg 
    1370                 1375                 1380             


Tyr Val  Ile Xaa His Leu Asn  Arg Val Ser Gln Gln  His Lys Ile 
    1385                 1390                 1395             


Asn Leu  Met Xaa Ala Asp Asn  Leu Ser Ile Cys Phe  Trp Pro Xaa 
    1400                 1405                 1410             


Leu Met  Arg Pro Asp Leu Lys  Ile Glu Phe Leu Ser  Xaa Xaa Lys 
    1415                 1420                 1425             


Ile His  Gln Ser Val Val Glu  Xaa Phe Ile Gln Gln  Cys Gln Phe 
    1430                 1435                 1440             


Phe Phe  Tyr Asn Gly Glu Ile  Val Glu Xaa Xaa Asn  Ile Val Ala 
    1445                 1450                 1455             


Pro Pro  Pro Pro Ser Asn Pro  Gly Gln Leu Val Glu  Pro Met Val 
    1460                 1465                 1470             


Pro Leu  Gln Leu Pro Pro Pro  Leu Gln Pro Gln Leu  Ile Gln Pro 
    1475                 1480                 1485             


Gln Leu  Gln Xaa Asp Pro Leu  Gly Ile Ile 
    1490                 1495             


<210> 2895
<211> 1501
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1206)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1243)..(1243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1268)..(1268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1287)..(1287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1291)..(1291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1325)..(1325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1363)..(1363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1415)..(1415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1429)..(1430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1439)..(1439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1456)..(1457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1495)..(1495)
<223> Selenocysteine

<400> 2895
Met Met Ala Lys Asn Lys Glu Pro Arg Pro Pro Ser Tyr Xaa Ile Ser 
1               5                   10                  15      


Ile Val Gly Leu Ser Gly Xaa Glu Lys Asp Lys Gly Asn Cys Gly Val 
            20                  25                  30          


Gly Lys Ser Cys Leu Cys Asn Arg Phe Val Arg Ser Lys Ala Asp Glu 
        35                  40                  45              


Tyr Tyr Pro Glu His Xaa Ser Val Leu Ser Xaa Ile Asp Phe Gly Gly 
    50                  55                  60                  


Arg Val Val Asn Asn Asp His Phe Leu Tyr Trp Gly Asp Ile Ile Gln 
65                  70                  75                  80  


Asn Ser Glu Asp Gly Val Glu Cys Lys Ile His Val Ile Glu Gln Xaa 
                85                  90                  95      


Glu Phe Ile Asp Asp Gln Xaa Phe Leu Pro His Arg Ser Xaa Asn Leu 
            100                 105                 110         


Gln Pro Tyr Ile Lys Arg Ala Ala Ala Ser Lys Leu Gln Ser Ala Glu 
        115                 120                 125             


Lys Leu Met Tyr Ile Cys Xaa Asp Gln Leu Gly Leu Glu Gln Asp Phe 
    130                 135                 140                 


Glu Gln Lys Gln Met Pro Glu Gly Lys Leu Asn Val Asp Gly Phe Leu 
145                 150                 155                 160 


Leu Cys Ile Asp Val Ser Gln Gly Cys Asn Arg Lys Phe Asp Asp Gln 
                165                 170                 175     


Leu Lys Phe Val Asn Asn Leu Phe Val Gln Leu Ser Lys Ser Lys Lys 
            180                 185                 190         


Pro Val Ile Ile Ala Ala Xaa Lys Cys Asp Glu Cys Val Asp His Tyr 
        195                 200                 205             


Leu Arg Glu Val Gln Ala Phe Ala Ser Asn Lys Lys Asn Leu Leu Val 
    210                 215                 220                 


Val Glu Xaa Ser Ala Arg Phe Asn Val Asn Ile Glu Xaa Cys Phe Xaa 
225                 230                 235                 240 


Ala Leu Val Gln Met Leu Asp Lys Xaa Arg Ser Lys Pro Lys Ile Ile 
                245                 250                 255     


Pro Tyr Leu Asp Ala Tyr Lys Xaa Gln Arg Gln Leu Val Val Xaa Ala 
            260                 265                 270         


Xaa Asp Lys Phe Glu Lys Leu Val Gln Xaa Val Arg Asp Tyr His Ala 
        275                 280                 285             


Xaa Trp Lys Xaa Val Ser Asn Lys Leu Lys Asn His Pro Asp Tyr Glu 
    290                 295                 300                 


Glu Tyr Ile Asn Leu Glu Gly Xaa Arg Lys Ala Arg Asn Xaa Phe Ser 
305                 310                 315                 320 


Lys His Ile Glu Gln Leu Lys Gln Glu His Ile Arg Lys Arg Arg Glu 
                325                 330                 335     


Glu Tyr Ile Asn Xaa Leu Pro Arg Ala Phe Asn Xaa Leu Leu Pro Asn 
            340                 345                 350         


Leu Glu Glu Ile Glu His Leu Asn Trp Ser Glu Ala Leu Lys Leu Met 
        355                 360                 365             


Glu Lys Arg Ala Asp Phe Gln Leu Cys Phe Val Val Leu Glu Lys Xaa 
    370                 375                 380                 


Pro Trp Asp Glu Xaa Asp His Ile Asp Lys Ile Asn Asp Arg Arg Ile 
385                 390                 395                 400 


Pro Phe Asp Leu Leu Ser Xaa Leu Glu Ala Glu Lys Val Tyr Gln Asn 
                405                 410                 415     


His Val Gln His Leu Ile Ser Glu Lys Arg Arg Val Glu Met Lys Glu 
            420                 425                 430         


Lys Phe Lys Lys Xaa Leu Glu Lys Ile Gln Phe Ile Ser Pro Gly Gln 
        435                 440                 445             


Pro Trp Glu Glu Val Met Cys Phe Val Met Glu Asp Glu Ala Tyr Lys 
    450                 455                 460                 


Tyr Ile Xaa Glu Ala Asp Ser Lys Glu Val Tyr Gly Arg His Gln Arg 
465                 470                 475                 480 


Glu Ile Val Glu Lys Ala Lys Glu Glu Phe Gln Glu Met Leu Phe Glu 
                485                 490                 495     


His Ser Glu Leu Phe Tyr Asp Leu Asp Leu Asn Ala Xaa Pro Ser Ser 
            500                 505                 510         


Asp Lys Met Ser Glu Ile His Xaa Val Leu Ser Glu Glu Pro Arg Tyr 
        515                 520                 525             


Lys Ala Leu Gln Lys Leu Ala Pro Asp Arg Glu Ser Leu Leu Leu Lys 
    530                 535                 540                 


His Ile Gly Phe Val Tyr His Pro Xaa Lys Glu Xaa Cys Leu Ser Gly 
545                 550                 555                 560 


Gln Asn Cys Xaa Asp Ile Lys Val Glu Gln Leu Leu Ala Ser Ser Leu 
                565                 570                 575     


Leu Gln Leu Asp His Gly Arg Leu Arg Leu Tyr His Asp Ser Xaa Asn 
            580                 585                 590         


Ile Asp Lys Val Asn Leu Phe Ile Leu Gly Lys Asp Gly Leu Ala Gln 
        595                 600                 605             


Glu Leu Ala Asn Glu Ile Arg Xaa Gln Ser Xaa Asp Asp Glu Tyr Ala 
    610                 615                 620                 


Leu Asp Gly Lys Ile Tyr Glu Leu Asp Leu Arg Pro Val Asp Ala Lys 
625                 630                 635                 640 


Ser Pro Tyr Phe Leu Ser Gln Leu Trp Xaa Ala Ala Phe Lys Pro His 
                645                 650                 655     


Gly Cys Phe Cys Val Phe Asn Ser Ile Glu Ser Leu Ser Phe Ile Gly 
            660                 665                 670         


Glu Phe Ile Gly Lys Ile Arg Xaa Glu Ala Ser Gln Ile Arg Lys Asp 
        675                 680                 685             


Lys Tyr Met Ala Asn Leu Pro Phe Xaa Leu Ile Leu Ala Asn Gln Arg 
    690                 695                 700                 


Asp Ser Ile Ser Lys Asn Leu Pro Ile Leu Arg His Gln Gly Gln Gln 
705                 710                 715                 720 


Leu Ala Asn Lys Leu Gln Cys Pro Phe Val Asp Val Pro Ala Gly Xaa 
                725                 730                 735     


Tyr Pro Arg Lys Phe Asn Glu Xaa Gln Ile Lys Gln Ala Leu Arg Gly 
            740                 745                 750         


Val Leu Glu Ser Val Lys His Asn Leu Asp Val Val Ser Pro Ile Pro 
        755                 760                 765             


Ala Asn Lys Asp Leu Ser Glu Ala Asp Leu Arg Ile Val Met Cys Ala 
    770                 775                 780                 


Met Cys Gly Asp Pro Phe Ser Val Asp Leu Ile Leu Ser Pro Phe Leu 
785                 790                 795                 800 


Asp Ser His Ser Cys Ser Ala Ala Gln Ala Gly Gln Asn Asn Ser Leu 
                805                 810                 815     


Met Leu Asp Lys Ile Ile Gly Glu Lys Arg Arg Arg Ile Gln Ile Xaa 
            820                 825                 830         


Ile Leu Ser Tyr His Ser Ser Ile Gly Val Arg Lys Asp Glu Leu Val 
        835                 840                 845             


His Gly Tyr Ile Leu Val Tyr Ser Ala Lys Arg Lys Ala Ser Met Gly 
    850                 855                 860                 


Met Leu Arg Ala Phe Leu Ser Glu Val Gln Asp Xaa Ile Pro Val Gln 
865                 870                 875                 880 


Leu Val Ala Val Xaa Asp Ser Gln Ala Asp Phe Phe Glu Asn Glu Ala 
                885                 890                 895     


Ile Lys Glu Leu Met Xaa Glu Gly Glu His Ile Ala Xaa Glu Ile Xaa 
            900                 905                 910         


Ala Lys Phe Xaa Ala Leu Tyr Ser Leu Ser Gln Tyr His Arg Gln Xaa 
        915                 920                 925             


Glu Val Phe Xaa Leu Phe Phe Ser Asp Val Leu Glu Lys Lys Asn Met 
    930                 935                 940                 


Ile Glu Asn Ser Tyr Leu Ser Asp Asn Xaa Arg Glu Ser Xaa His Gln 
945                 950                 955                 960 


Ser Glu Asp Val Phe Leu Pro Ser Pro Arg Asp Cys Phe Pro Tyr Asn 
                965                 970                 975     


Asn Tyr Pro Asp Ser Asp Asp Asp Xaa Glu Ala Pro Pro Pro Tyr Ser 
            980                 985                 990         


Pro Ile Gly Asp Asp Val Gln Leu  Leu Pro Xaa Pro Ser  Asp Arg Ser 
        995                 1000                 1005             


Arg Tyr  Arg Leu Asp Leu Glu  Gly Asn Glu Tyr Pro  Ile His Ser 
    1010                 1015                 1020             


Xaa Pro  Asn Cys His Asp His  Glu Arg Asn His Lys  Val Pro Pro 
    1025                 1030                 1035             


Pro Ile  Lys Pro Lys Pro Val  Val Pro Lys Xaa Asn  Val Lys Lys 
    1040                 1045                 1050             


Leu Asp  Pro Asn Leu Leu Lys  Xaa Ile Glu Ala Gly  Ile Gly Lys 
    1055                 1060                 1065             


Asn Pro  Arg Lys Gln Xaa Ser  Arg Val Pro Leu Ala  His Pro Glu 
    1070                 1075                 1080             


Asp Met  Asp Pro Ser Asp Asn  Tyr Ala Glu Pro Ile  Asp Xaa Ile 
    1085                 1090                 1095             


Phe Lys  Gln Lys Gly Tyr Ser  Asp Glu Ile Tyr Val  Val Pro Asp 
    1100                 1105                 1110             


Asp Ser  Gln Asn Arg Ile Lys  Ile Arg Asn Ser Phe  Val Asn Asn 
    1115                 1120                 1125             


Xaa Gln  Gly Asp Glu Glu Asn  Gly Phe Ser Asp Arg  Xaa Ser Lys 
    1130                 1135                 1140             


Ser His  Gly Glu Arg Arg Pro  Ser Lys Tyr Lys Tyr  Lys Ser Lys 
    1145                 1150                 1155             


Xaa Leu  Phe Ser Lys Ala Lys  Ser Tyr Tyr Arg Arg  Xaa His Ser 
    1160                 1165                 1170             


Asp Ala  Ser Asp Asp Glu Ala  Phe Xaa Xaa Ser Lys  Xaa Lys Arg 
    1175                 1180                 1185             


Lys Gly  Arg His Arg Gly Ser  Glu Glu Asp Pro Leu  Leu Ser Pro 
    1190                 1195                 1200             


Val Glu  Xaa Trp Lys Gly Gly  Ile Asp Asn Pro Ala  Ile Xaa Ser 
    1205                 1210                 1215             


Asp Gln  Glu Leu Asp Asp Lys  Lys Met Lys Lys Lys  Xaa His Lys 
    1220                 1225                 1230             


Val Lys  Glu Asp Lys Lys Lys  Lys Lys Xaa Lys Asn  Phe Asn Pro 
    1235                 1240                 1245             


Pro Xaa  Arg Arg Asn Trp Glu  Ser Asn Tyr Phe Gly  Met Pro Leu 
    1250                 1255                 1260             


Gln Asp  Leu Val Xaa Ala Glu  Lys Pro Ile Pro Leu  Phe Val Glu 
    1265                 1270                 1275             


Lys Cys  Val Glu Phe Ile Glu  Asp Xaa Gly Leu Cys  Xaa Glu Gly 
    1280                 1285                 1290             


Leu Tyr  Arg Val Ser Gly Asn  Lys Xaa Asp Gln Asp  Asn Ile Gln 
    1295                 1300                 1305             


Lys Gln  Phe Asp Gln Asp His  Asn Ile Asn Leu Val  Ser Met Glu 
    1310                 1315                 1320             


Val Xaa  Val Asn Ala Val Ala  Gly Ala Leu Lys Ala  Phe Phe Ala 
    1325                 1330                 1335             


Asp Leu  Pro Asp Pro Leu Ile  Pro Tyr Ser Leu His  Pro Glu Leu 
    1340                 1345                 1350             


Leu Glu  Ala Ala Lys Ile Pro  Asp Lys Xaa Glu Arg  Leu His Ala 
    1355                 1360                 1365             


Leu Lys  Glu Ile Val Lys Lys  Phe His Pro Val Asn  Tyr Asp Val 
    1370                 1375                 1380             


Phe Arg  Tyr Val Ile Xaa His  Leu Asn Arg Val Ser  Gln Gln His 
    1385                 1390                 1395             


Lys Ile  Asn Leu Met Xaa Ala  Asp Asn Leu Ser Ile  Cys Phe Trp 
    1400                 1405                 1410             


Pro Xaa  Leu Met Arg Pro Asp  Phe Glu Asn Arg Glu  Phe Leu Ser 
    1415                 1420                 1425             


Xaa Xaa  Lys Ile His Gln Ser  Val Val Glu Xaa Phe  Ile Gln Gln 
    1430                 1435                 1440             


Cys Gln  Phe Phe Phe Tyr Asn  Gly Glu Ile Val Glu  Xaa Xaa Asn 
    1445                 1450                 1455             


Ile Val  Ala Pro Pro Pro Pro  Ser Asn Pro Gly Gln  Leu Val Glu 
    1460                 1465                 1470             


Pro Met  Val Pro Leu Gln Leu  Pro Pro Pro Leu Gln  Pro Gln Leu 
    1475                 1480                 1485             


Ile Gln  Pro Gln Leu Gln Xaa  Asp Pro Leu Gly Ile  Ile 
    1490                 1495                 1500     


<210> 2896
<211> 1502
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1206)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1244)..(1244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1364)..(1364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1405)..(1405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1416)..(1416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1430)..(1431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1440)..(1440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1496)..(1496)
<223> Selenocysteine

<400> 2896
Met Met Ala Lys Asn Lys Glu Pro Arg Pro Pro Ser Tyr Xaa Ile Ser 
1               5                   10                  15      


Ile Val Gly Leu Ser Gly Xaa Glu Lys Asp Lys Gly Asn Cys Gly Val 
            20                  25                  30          


Gly Lys Ser Cys Leu Cys Asn Arg Phe Val Arg Ser Lys Ala Asp Glu 
        35                  40                  45              


Tyr Tyr Pro Glu His Xaa Ser Val Leu Ser Xaa Ile Asp Phe Gly Gly 
    50                  55                  60                  


Arg Val Val Asn Asn Asp His Phe Leu Tyr Trp Gly Asp Ile Ile Gln 
65                  70                  75                  80  


Asn Ser Glu Asp Gly Val Glu Cys Lys Ile His Val Ile Glu Gln Xaa 
                85                  90                  95      


Glu Phe Ile Asp Asp Gln Xaa Phe Leu Pro His Arg Ser Xaa Asn Leu 
            100                 105                 110         


Gln Pro Tyr Ile Lys Arg Ala Ala Ala Ser Lys Leu Gln Ser Ala Glu 
        115                 120                 125             


Lys Leu Met Tyr Ile Cys Xaa Asp Gln Leu Gly Leu Glu Gln Asp Phe 
    130                 135                 140                 


Glu Gln Lys Gln Met Pro Glu Gly Lys Leu Asn Val Asp Gly Phe Leu 
145                 150                 155                 160 


Leu Cys Ile Asp Val Ser Gln Gly Cys Asn Arg Lys Phe Asp Asp Gln 
                165                 170                 175     


Leu Lys Phe Val Asn Asn Leu Phe Val Gln Leu Ser Lys Ser Lys Lys 
            180                 185                 190         


Pro Val Ile Ile Ala Ala Xaa Lys Cys Asp Glu Cys Val Asp His Tyr 
        195                 200                 205             


Leu Arg Glu Val Gln Ala Phe Ala Ser Asn Lys Lys Asn Leu Leu Val 
    210                 215                 220                 


Val Glu Xaa Ser Ala Arg Phe Asn Val Asn Ile Glu Xaa Cys Phe Xaa 
225                 230                 235                 240 


Ala Leu Val Gln Met Leu Asp Lys Xaa Arg Ser Lys Pro Lys Ile Ile 
                245                 250                 255     


Pro Tyr Leu Asp Ala Tyr Lys Xaa Gln Arg Gln Leu Val Val Xaa Ala 
            260                 265                 270         


Xaa Asp Lys Phe Glu Lys Leu Val Gln Xaa Val Arg Asp Tyr His Ala 
        275                 280                 285             


Xaa Trp Lys Xaa Val Ser Asn Lys Leu Lys Asn His Pro Asp Tyr Glu 
    290                 295                 300                 


Glu Tyr Ile Asn Leu Glu Gly Xaa Arg Lys Ala Arg Asn Xaa Phe Ser 
305                 310                 315                 320 


Lys His Ile Glu Gln Leu Lys Gln Glu His Ile Arg Lys Arg Arg Glu 
                325                 330                 335     


Glu Tyr Ile Asn Xaa Leu Pro Arg Ala Phe Asn Xaa Leu Leu Pro Asn 
            340                 345                 350         


Leu Glu Glu Ile Glu His Leu Asn Trp Ser Glu Ala Leu Lys Leu Met 
        355                 360                 365             


Glu Lys Arg Ala Asp Phe Gln Leu Cys Phe Val Val Leu Glu Lys Xaa 
    370                 375                 380                 


Pro Trp Asp Glu Xaa Asp His Ile Asp Lys Ile Asn Asp Arg Arg Ile 
385                 390                 395                 400 


Pro Phe Asp Leu Leu Ser Xaa Leu Glu Ala Glu Lys Val Tyr Gln Asn 
                405                 410                 415     


His Val Gln His Leu Ile Ser Glu Lys Arg Arg Val Glu Met Lys Glu 
            420                 425                 430         


Lys Phe Lys Lys Xaa Leu Glu Lys Ile Gln Phe Ile Ser Pro Gly Gln 
        435                 440                 445             


Pro Trp Glu Glu Val Met Cys Phe Val Met Glu Asp Glu Ala Tyr Lys 
    450                 455                 460                 


Tyr Ile Xaa Glu Ala Asp Ser Lys Glu Val Tyr Gly Arg His Gln Arg 
465                 470                 475                 480 


Glu Ile Val Glu Lys Ala Lys Glu Glu Phe Gln Glu Met Leu Phe Glu 
                485                 490                 495     


His Ser Glu Leu Phe Tyr Asp Leu Asp Leu Asn Ala Xaa Pro Ser Ser 
            500                 505                 510         


Asp Lys Met Ser Glu Ile His Xaa Val Leu Ser Glu Glu Pro Arg Tyr 
        515                 520                 525             


Lys Ala Leu Gln Lys Leu Ala Pro Asp Arg Glu Ser Leu Leu Leu Lys 
    530                 535                 540                 


His Ile Gly Phe Val Tyr His Pro Xaa Lys Glu Xaa Cys Leu Ser Gly 
545                 550                 555                 560 


Gln Asn Cys Xaa Asp Ile Lys Val Glu Gln Leu Leu Ala Ser Ser Leu 
                565                 570                 575     


Leu Gln Leu Asp His Gly Arg Leu Arg Leu Tyr His Asp Ser Xaa Asn 
            580                 585                 590         


Ile Asp Lys Val Asn Leu Phe Ile Leu Gly Lys Asp Gly Leu Ala Gln 
        595                 600                 605             


Glu Leu Ala Asn Glu Ile Arg Xaa Gln Ser Xaa Asp Asp Glu Tyr Ala 
    610                 615                 620                 


Leu Asp Gly Lys Ile Tyr Glu Leu Asp Leu Arg Pro Val Asp Ala Lys 
625                 630                 635                 640 


Ser Pro Tyr Phe Leu Ser Gln Leu Trp Xaa Ala Ala Phe Lys Pro His 
                645                 650                 655     


Gly Cys Phe Cys Val Phe Asn Ser Ile Glu Ser Leu Ser Phe Ile Gly 
            660                 665                 670         


Glu Phe Ile Gly Lys Ile Arg Xaa Glu Ala Ser Gln Ile Arg Lys Asp 
        675                 680                 685             


Lys Tyr Met Ala Asn Leu Pro Phe Xaa Leu Ile Leu Ala Asn Gln Arg 
    690                 695                 700                 


Asp Ser Ile Ser Lys Asn Leu Pro Ile Leu Arg His Gln Gly Gln Gln 
705                 710                 715                 720 


Leu Ala Asn Lys Leu Gln Cys Pro Phe Val Asp Val Pro Ala Gly Xaa 
                725                 730                 735     


Tyr Pro Arg Lys Phe Asn Glu Xaa Gln Ile Lys Gln Ala Leu Arg Gly 
            740                 745                 750         


Val Leu Glu Ser Val Lys His Asn Leu Asp Val Val Ser Pro Ile Pro 
        755                 760                 765             


Ala Asn Lys Asp Leu Ser Glu Ala Asp Leu Arg Ile Val Met Cys Ala 
    770                 775                 780                 


Met Cys Gly Asp Pro Phe Ser Val Asp Leu Ile Leu Ser Pro Phe Leu 
785                 790                 795                 800 


Asp Ser His Ser Cys Ser Ala Ala Gln Ala Gly Gln Asn Asn Ser Leu 
                805                 810                 815     


Met Leu Asp Lys Ile Ile Gly Glu Lys Arg Arg Arg Ile Gln Ile Xaa 
            820                 825                 830         


Ile Leu Ser Tyr His Ser Ser Ile Gly Val Arg Lys Asp Glu Leu Val 
        835                 840                 845             


His Gly Tyr Ile Leu Val Tyr Ser Ala Lys Arg Lys Ala Ser Met Gly 
    850                 855                 860                 


Met Leu Arg Ala Phe Leu Ser Glu Val Gln Asp Xaa Ile Pro Val Gln 
865                 870                 875                 880 


Leu Val Ala Val Xaa Asp Ser Gln Ala Asp Phe Phe Glu Asn Glu Ala 
                885                 890                 895     


Ile Lys Glu Leu Met Xaa Glu Gly Glu His Ile Ala Xaa Glu Ile Xaa 
            900                 905                 910         


Ala Lys Phe Xaa Ala Leu Tyr Ser Leu Ser Gln Tyr His Arg Gln Xaa 
        915                 920                 925             


Glu Val Phe Xaa Leu Phe Phe Ser Asp Val Leu Glu Lys Lys Asn Met 
    930                 935                 940                 


Ile Glu Asn Ser Tyr Leu Ser Asp Asn Xaa Arg Glu Ser Xaa His Gln 
945                 950                 955                 960 


Ser Glu Asp Val Phe Leu Pro Ser Pro Arg Asp Cys Phe Pro Tyr Asn 
                965                 970                 975     


Asn Tyr Pro Asp Ser Asp Asp Asp Xaa Glu Ala Pro Pro Pro Tyr Ser 
            980                 985                 990         


Pro Ile Gly Asp Asp Val Gln Leu  Leu Pro Xaa Pro Ser  Asp Arg Ser 
        995                 1000                 1005             


Arg Tyr  Arg Leu Asp Leu Glu  Gly Asn Glu Tyr Pro  Ile His Ser 
    1010                 1015                 1020             


Xaa Pro  Asn Cys His Asp His  Glu Arg Asn His Lys  Val Pro Pro 
    1025                 1030                 1035             


Pro Ile  Lys Pro Lys Pro Val  Val Pro Lys Xaa Asn  Val Lys Lys 
    1040                 1045                 1050             


Leu Asp  Pro Asn Leu Leu Lys  Xaa Ile Glu Ala Gly  Ile Gly Lys 
    1055                 1060                 1065             


Asn Pro  Arg Lys Gln Xaa Ser  Arg Val Pro Leu Ala  His Pro Glu 
    1070                 1075                 1080             


Asp Met  Asp Pro Ser Asp Asn  Tyr Ala Glu Pro Ile  Asp Xaa Ile 
    1085                 1090                 1095             


Phe Lys  Gln Lys Gly Tyr Ser  Asp Glu Ile Tyr Val  Val Pro Asp 
    1100                 1105                 1110             


Asp Ser  Gln Asn Arg Ile Lys  Ile Arg Asn Ser Phe  Val Asn Asn 
    1115                 1120                 1125             


Xaa Gln  Gly Asp Glu Glu Asn  Gly Phe Ser Asp Arg  Xaa Ser Lys 
    1130                 1135                 1140             


Ser His  Gly Glu Arg Arg Pro  Ser Lys Tyr Lys Tyr  Lys Ser Lys 
    1145                 1150                 1155             


Xaa Leu  Phe Ser Lys Ala Lys  Ser Tyr Tyr Arg Arg  Xaa His Ser 
    1160                 1165                 1170             


Asp Ala  Ser Asp Asp Glu Ala  Phe Xaa Xaa Ser Lys  Xaa Lys Arg 
    1175                 1180                 1185             


Lys Gly  Arg His Arg Gly Ser  Glu Glu Asp Pro Leu  Leu Ser Pro 
    1190                 1195                 1200             


Val Glu  Xaa Trp Lys Gly Gly  Ile Asp Asn Pro Ala  Ile Xaa Ser 
    1205                 1210                 1215             


Asp Gln  Glu Leu Asp Asp Lys  Lys Met Lys Lys Lys  Xaa His Lys 
    1220                 1225                 1230             


Val Lys  Glu Asp Lys Lys Gln  Lys Lys Lys Xaa Lys  Asn Phe Asn 
    1235                 1240                 1245             


Pro Pro  Xaa Arg Arg Asn Trp  Glu Ser Asn Tyr Phe  Gly Met Pro 
    1250                 1255                 1260             


Leu Gln  Asp Leu Val Xaa Ala  Glu Lys Pro Ile Pro  Leu Phe Val 
    1265                 1270                 1275             


Glu Lys  Cys Val Glu Phe Ile  Glu Asp Xaa Gly Leu  Cys Xaa Glu 
    1280                 1285                 1290             


Gly Leu  Tyr Arg Val Ser Gly  Asn Lys Xaa Asp Gln  Asp Asn Ile 
    1295                 1300                 1305             


Gln Lys  Gln Phe Asp Gln Asp  His Asn Ile Asn Leu  Val Ser Met 
    1310                 1315                 1320             


Glu Val  Xaa Val Asn Ala Val  Ala Gly Ala Leu Lys  Ala Phe Phe 
    1325                 1330                 1335             


Ala Asp  Leu Pro Asp Pro Leu  Ile Pro Tyr Ser Leu  His Pro Glu 
    1340                 1345                 1350             


Leu Leu  Glu Ala Ala Lys Ile  Pro Asp Lys Xaa Glu  Arg Leu His 
    1355                 1360                 1365             


Ala Leu  Lys Glu Ile Val Lys  Lys Phe His Pro Val  Asn Tyr Asp 
    1370                 1375                 1380             


Val Phe  Arg Tyr Val Ile Xaa  His Leu Asn Arg Val  Ser Gln Gln 
    1385                 1390                 1395             


His Lys  Ile Asn Leu Met Xaa  Ala Asp Asn Leu Ser  Ile Cys Phe 
    1400                 1405                 1410             


Trp Pro  Xaa Leu Met Arg Pro  Asp Phe Glu Asn Arg  Glu Phe Leu 
    1415                 1420                 1425             


Ser Xaa  Xaa Lys Ile His Gln  Ser Val Val Glu Xaa  Phe Ile Gln 
    1430                 1435                 1440             


Gln Cys  Gln Phe Phe Phe Tyr  Asn Gly Glu Ile Val  Glu Xaa Xaa 
    1445                 1450                 1455             


Asn Ile  Val Ala Pro Pro Pro  Pro Ser Asn Pro Gly  Gln Leu Val 
    1460                 1465                 1470             


Glu Pro  Met Val Pro Leu Gln  Leu Pro Pro Pro Leu  Gln Pro Gln 
    1475                 1480                 1485             


Leu Ile  Gln Pro Gln Leu Gln  Xaa Asp Pro Leu Gly  Ile Ile 
    1490                 1495                 1500         


<210> 2897
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 2897
Met Pro Leu Gln Asp Leu Val Xaa Ala Glu Lys Pro Ile Pro Leu Phe 
1               5                   10                  15      


Val Glu Lys Cys Val Glu Phe Ile Glu Asp Xaa Gly Leu Cys Xaa Glu 
            20                  25                  30          


Gly Leu Tyr Arg Val Ser Gly Asn Lys Xaa Asp Gln Asp Asn Ile Gln 
        35                  40                  45              


Lys Gln Phe Asp Gln Asp His Asn Ile Asn Leu Val Ser Met Glu Val 
    50                  55                  60                  


Xaa Val Asn Ala Val Ala Gly Ala Leu Lys Ala Phe Phe Ala Asp Leu 
65                  70                  75                  80  


Pro Asp Pro Leu Ile Pro Tyr Ser Leu His Pro Glu Leu Leu Glu Ala 
                85                  90                  95      


Ala Lys Ile Pro Asp Lys Xaa Glu Arg Leu His Ala Leu Lys Glu Ile 
            100                 105                 110         


Val Lys Lys Phe His Pro Val Asn Tyr Asp Val Phe Arg Tyr Val Ile 
        115                 120                 125             


Xaa His Leu Asn Arg Val Ser Gln Gln 
    130                 135         


<210> 2898
<211> 241
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<400> 2898
Met Pro Leu Gln Asp Leu Val Xaa Ala Glu Lys Pro Ile Pro Leu Phe 
1               5                   10                  15      


Val Glu Lys Cys Val Glu Phe Ile Glu Asp Xaa Gly Leu Cys Xaa Glu 
            20                  25                  30          


Gly Leu Tyr Arg Val Ser Gly Asn Lys Xaa Asp Gln Asp Asn Ile Gln 
        35                  40                  45              


Lys Gln Phe Asp Gln Asp His Asn Ile Asn Leu Val Ser Met Glu Val 
    50                  55                  60                  


Xaa Val Asn Ala Val Ala Gly Ala Leu Lys Ala Phe Phe Ala Asp Leu 
65                  70                  75                  80  


Pro Asp Pro Leu Ile Pro Tyr Ser Leu His Pro Glu Leu Leu Glu Ala 
                85                  90                  95      


Ala Lys Ile Pro Asp Lys Xaa Glu Arg Leu His Ala Leu Lys Glu Ile 
            100                 105                 110         


Val Lys Lys Phe His Pro Val Asn Tyr Asp Val Phe Arg Tyr Val Ile 
        115                 120                 125             


Xaa His Leu Asn Arg Val Ser Gln Gln His Lys Ile Asn Leu Met Xaa 
    130                 135                 140                 


Ala Asp Asn Leu Ser Ile Cys Phe Trp Pro Xaa Leu Met Arg Pro Asp 
145                 150                 155                 160 


Phe Glu Asn Arg Glu Phe Leu Ser Xaa Xaa Lys Ile His Gln Ser Val 
                165                 170                 175     


Val Glu Xaa Phe Ile Gln Gln Cys Gln Phe Phe Phe Tyr Asn Gly Glu 
            180                 185                 190         


Ile Val Glu Xaa Xaa Asn Ile Val Ala Pro Pro Pro Pro Ser Asn Pro 
        195                 200                 205             


Gly Gln Leu Val Glu Pro Met Val Pro Leu Gln Leu Pro Pro Pro Leu 
    210                 215                 220                 


Gln Pro Gln Leu Ile Gln Pro Gln Leu Gln Xaa Asp Pro Leu Gly Ile 
225                 230                 235                 240 


Ile 
    


<210> 2899
<211> 237
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<400> 2899
Met Ser Leu Pro Pro Pro Pro Pro Gly Pro Leu Pro Leu Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Pro Xaa Leu Leu Gly Leu Cys Xaa Glu Gly Leu Tyr Arg 
            20                  25                  30          


Val Ser Gly Asn Lys Xaa Asp Gln Asp Asn Ile Gln Lys Gln Phe Asp 
        35                  40                  45              


Gln Asp His Asn Ile Asn Leu Val Ser Met Glu Val Xaa Val Asn Ala 
    50                  55                  60                  


Val Ala Gly Ala Leu Lys Ala Phe Phe Ala Asp Leu Pro Asp Pro Leu 
65                  70                  75                  80  


Ile Pro Tyr Ser Leu His Pro Glu Leu Leu Glu Ala Ala Lys Ile Pro 
                85                  90                  95      


Asp Lys Xaa Glu Arg Leu His Ala Leu Lys Glu Ile Val Lys Lys Phe 
            100                 105                 110         


His Pro Val Asn Tyr Asp Val Phe Arg Tyr Val Ile Xaa His Leu Asn 
        115                 120                 125             


Arg Val Ser Gln Gln His Lys Ile Asn Leu Met Xaa Ala Asp Asn Leu 
    130                 135                 140                 


Ser Ile Cys Phe Trp Pro Xaa Leu Met Arg Pro Asp Phe Glu Asn Arg 
145                 150                 155                 160 


Glu Phe Leu Ser Xaa Xaa Lys Ile His Gln Ser Val Val Glu Xaa Phe 
                165                 170                 175     


Ile Gln Gln Cys Gln Phe Phe Phe Tyr Asn Gly Glu Ile Val Glu Xaa 
            180                 185                 190         


Xaa Asn Ile Val Ala Pro Pro Pro Pro Ser Asn Pro Gly Gln Leu Val 
        195                 200                 205             


Glu Pro Met Val Pro Leu Gln Leu Pro Pro Pro Leu Gln Pro Gln Leu 
    210                 215                 220                 


Ile Gln Pro Gln Leu Gln Xaa Asp Pro Leu Gly Ile Ile 
225                 230                 235         


<210> 2900
<211> 148
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<400> 2900
Xaa Ser Phe Val Asn Asn Xaa Gln Gly Asp Glu Glu Asn Gly Phe Ser 
1               5                   10                  15      


Asp Arg Xaa Ser Lys Ser His Gly Glu Arg Arg Pro Ser Lys Tyr Lys 
            20                  25                  30          


Tyr Lys Ser Lys Xaa Leu Phe Ser Lys Ala Lys Ser Tyr Tyr Arg Arg 
        35                  40                  45              


Xaa His Ser Asp Ala Ser Asp Asp Glu Ala Phe Xaa Xaa Ser Lys Xaa 
    50                  55                  60                  


Lys Arg Lys Gly Arg His Arg Gly Ser Glu Glu Asp Pro Leu Leu Ser 
65                  70                  75                  80  


Pro Val Glu Xaa Trp Lys Gly Gly Ile Asp Asn Pro Ala Ile Xaa Ser 
                85                  90                  95      


Asp Gln Glu Leu Asp Asp Lys Lys Met Lys Lys Lys Xaa His Lys Val 
            100                 105                 110         


Lys Glu Asp Lys Lys Gly Tyr Val Pro Lys Asp Ser Xaa Val Ser Ala 
        115                 120                 125             


Gly Ile Lys Leu Xaa Lys Xaa Ile Phe Lys Ser Ser Leu Ile Lys Ile 
    130                 135                 140                 


Ile Ile Ser Ile 
145             


<210> 2901
<211> 601
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<400> 2901
Leu Glu Leu Tyr Asp Leu Gln Ile Leu Gly Xaa Lys Pro Pro Met Asn 
1               5                   10                  15      


Ser Asp Xaa His Arg Asn Phe Asp Pro Xaa Ala Xaa Leu Arg Asn Gln 
            20                  25                  30          


Gly Asp Phe Xaa Trp Asn Ser Met Ser Gly Arg Ser Val Arg Leu Arg 
        35                  40                  45              


Ser Val Pro Ile Gln Ser Leu Ser Glu Leu Glu Arg Ala Arg Leu Gln 
    50                  55                  60                  


Glu Val Ala Phe Tyr Gln Leu Gln Gln Asp Cys Asp Leu Ser Cys Gln 
65                  70                  75                  80  


Ile Xaa Ile Pro Lys Asp Gly Gln Lys Arg Lys Lys Ser Leu Arg Lys 
                85                  90                  95      


Lys Leu Asp Ser Leu Gly Lys Glu Lys Asn Lys Asp Lys Glu Phe Ile 
            100                 105                 110         


Pro Gln Ala Phe Gly Met Pro Leu Ser Gln Val Ile Ala Asn Asp Arg 
        115                 120                 125             


Ala Tyr Lys Leu Lys Gln Asp Leu Gln Arg Asp Glu Gln Lys Asp Ala 
    130                 135                 140                 


Ser Asp Phe Val Ala Ser Leu Leu Pro Phe Gly Asn Lys Arg Gln Asn 
145                 150                 155                 160 


Lys Glu Leu Ser Ser Ser Asn Ser Ser Leu Ser Ser Xaa Ser Glu Xaa 
                165                 170                 175     


Pro Asn Glu Ser Xaa Ser Pro Asn Xaa Pro Glu Pro Ala Pro Arg Ala 
            180                 185                 190         


Arg Arg Arg Gly Ala Met Ser Val Asp Ser Ile Xaa Asp Leu Asp Asp 
        195                 200                 205             


Asn Gln Ser Arg Leu Leu Glu Ala Leu Gln Leu Ser Leu Pro Ala Glu 
    210                 215                 220                 


Ala Gln Ser Lys Lys Glu Lys Ala Arg Asp Lys Lys Leu Ser Leu Asn 
225                 230                 235                 240 


Pro Ile Tyr Arg Gln Val Pro Arg Leu Val Asp Ser Cys Cys Gln His 
                245                 250                 255     


Leu Glu Lys His Gly Leu Gln Xaa Val Gly Ile Phe Arg Val Gly Ser 
            260                 265                 270         


Ser Lys Lys Arg Val Arg Gln Leu Arg Glu Glu Phe Asp Arg Gly Ile 
        275                 280                 285             


Asp Val Ser Leu Glu Glu Glu His Ser Val His Asp Val Ala Ala Leu 
    290                 295                 300                 


Leu Lys Glu Phe Leu Arg Asp Met Pro Asp Pro Leu Leu Xaa Arg Glu 
305                 310                 315                 320 


Leu Tyr Xaa Ala Phe Ile Asn Xaa Leu Leu Leu Glu Pro Glu Glu Gln 
                325                 330                 335     


Leu Gly Xaa Leu Gln Leu Leu Ile Tyr Leu Leu Pro Pro Cys Asn Cys 
            340                 345                 350         


Asp Xaa Leu His Arg Leu Leu Gln Phe Leu Ser Ile Val Ala Arg His 
        355                 360                 365             


Ala Asp Asp Asn Ile Ser Lys Asp Gly Gln Glu Val Xaa Gly Asn Lys 
    370                 375                 380                 


Met Xaa Ser Leu Asn Leu Ala Xaa Ile Phe Gly Pro Asn Leu Leu His 
385                 390                 395                 400 


Lys Gln Lys Ser Ser Asp Lys Glu Phe Ser Val Gln Ser Ser Ala Arg 
                405                 410                 415     


Ala Glu Glu Ser Xaa Ala Ile Ile Ala Val Val Gln Lys Met Ile Glu 
            420                 425                 430         


Asn Tyr Glu Ala Leu Phe Met Val Pro Pro Asp Leu Gln Asn Glu Val 
        435                 440                 445             


Leu Ile Ser Leu Leu Glu Xaa Asp Pro Asp Val Val Asp Tyr Leu Leu 
    450                 455                 460                 


Arg Arg Lys Ala Ser Gln Ser Ser Ser Pro Asp Met Leu Gln Ser Glu 
465                 470                 475                 480 


Val Ser Phe Ser Val Gly Gly Arg His Ser Ser Xaa Asp Ser Asn Lys 
                485                 490                 495     


Ala Ser Ser Gly Asp Ile Ser Pro Tyr Asp Asn Asn Ser Pro Val Leu 
            500                 505                 510         


Ser Glu Arg Ser Leu Leu Ala Met Gln Glu Asp Ala Ala Pro Gly Gly 
        515                 520                 525             


Ser Glu Lys Leu Tyr Arg Val Pro Gly Gln Phe Met Leu Val Gly His 
    530                 535                 540                 


Leu Ser Ser Ser Lys Ser Arg Glu Ser Ser Pro Gly Pro Arg Leu Gly 
545                 550                 555                 560 


Lys Gly Asn Trp Ser Leu Ala Ser Arg Arg Trp Pro Lys Gln Ala Xaa 
                565                 570                 575     


Leu Leu Leu Leu His Val Ala Trp Cys Gly Ala Leu Arg Xaa Phe Ser 
            580                 585                 590         


Ser Ser Leu Pro Tyr Leu Met Phe Leu 
        595                 600     


<210> 2902
<211> 765
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<400> 2902
Met Ser Ala Gln Ser Leu Leu His Ser Val Phe Ser Cys Ser Ser Pro 
1               5                   10                  15      


Ala Ser Ser Ser Ala Ala Ser Ala Lys Gly Phe Ser Lys Arg Lys Leu 
            20                  25                  30          


Arg Gln Xaa Arg Ser Leu Asp Pro Ala Leu Ile Gly Gly Cys Gly Ser 
        35                  40                  45              


Asp Glu Ala Gly Ala Glu Gly Ser Ala Arg Gly Ala Xaa Ala Gly Arg 
    50                  55                  60                  


Leu Tyr Ser Pro Ser Leu Pro Ala Glu Ser Leu Gly Pro Arg Leu Ala 
65                  70                  75                  80  


Ser Ser Ser Arg Gly Pro Pro Pro Arg Ala Xaa Arg Leu Pro Pro Pro 
                85                  90                  95      


Gly Pro Leu Cys Ser Ser Phe Ser Xaa Pro Ser Xaa Pro Gln Glu Lys 
            100                 105                 110         


Ser Pro Ser Gly Ser Phe His Phe Asp Tyr Glu Val Pro Leu Gly Arg 
        115                 120                 125             


Gly Gly Leu Lys Lys Ser Met Ala Trp Asp Leu Pro Ser Val Leu Ala 
    130                 135                 140                 


Gly Pro Ala Ser Ser Arg Ser Ala Ser Ser Ile Leu Cys Ser Ser Gly 
145                 150                 155                 160 


Gly Gly Pro Asn Gly Ile Phe Ala Ser Pro Arg Arg Trp Leu Gln Gln 
                165                 170                 175     


Arg Lys Phe Gln Ser Pro Pro Asp Ser Arg Gly His Pro Tyr Val Val 
            180                 185                 190         


Trp Lys Ser Glu Gly Asp Phe Xaa Trp Asn Ser Met Ser Gly Arg Ser 
        195                 200                 205             


Val Arg Leu Arg Ser Val Pro Ile Gln Ser Leu Ser Glu Leu Glu Arg 
    210                 215                 220                 


Ala Arg Leu Gln Glu Val Ala Phe Tyr Gln Leu Gln Gln Asp Cys Asp 
225                 230                 235                 240 


Leu Ser Cys Gln Ile Xaa Ile Pro Lys Asp Gly Gln Lys Arg Lys Lys 
                245                 250                 255     


Ser Leu Arg Lys Lys Leu Asp Ser Leu Gly Lys Glu Lys Asn Lys Asp 
            260                 265                 270         


Lys Glu Phe Ile Pro Gln Ala Phe Gly Met Pro Leu Ser Gln Val Ile 
        275                 280                 285             


Ala Asn Asp Arg Ala Tyr Lys Leu Lys Gln Asp Leu Gln Arg Asp Glu 
    290                 295                 300                 


Gln Lys Asp Ala Ser Asp Phe Val Ala Ser Leu Leu Pro Phe Gly Asn 
305                 310                 315                 320 


Lys Arg Gln Asn Lys Glu Leu Ser Ser Ser Asn Ser Ser Leu Ser Ser 
                325                 330                 335     


Xaa Ser Glu Xaa Pro Asn Glu Ser Xaa Ser Pro Asn Xaa Pro Glu Pro 
            340                 345                 350         


Ala Pro Arg Ala Arg Arg Arg Gly Ala Met Ser Val Asp Ser Ile Xaa 
        355                 360                 365             


Asp Leu Asp Asp Asn Gln Ser Arg Leu Leu Glu Ala Leu Gln Leu Ser 
    370                 375                 380                 


Leu Pro Ala Glu Ala Gln Ser Lys Lys Glu Lys Ala Arg Asp Lys Lys 
385                 390                 395                 400 


Leu Ser Leu Asn Pro Ile Tyr Arg Gln Val Pro Arg Leu Val Asp Ser 
                405                 410                 415     


Cys Cys Gln His Leu Glu Lys His Gly Leu Gln Xaa Val Gly Ile Phe 
            420                 425                 430         


Arg Val Gly Ser Ser Lys Lys Arg Val Arg Gln Leu Arg Glu Glu Phe 
        435                 440                 445             


Asp Arg Gly Ile Asp Val Ser Leu Glu Glu Glu His Ser Val His Asp 
    450                 455                 460                 


Val Ala Ala Leu Leu Lys Glu Phe Leu Arg Asp Met Pro Asp Pro Leu 
465                 470                 475                 480 


Leu Xaa Arg Glu Leu Tyr Xaa Ala Phe Ile Asn Xaa Leu Leu Leu Glu 
                485                 490                 495     


Pro Glu Glu Gln Leu Gly Xaa Leu Gln Leu Leu Ile Tyr Leu Leu Pro 
            500                 505                 510         


Pro Cys Asn Cys Asp Xaa Leu His Arg Leu Leu Gln Phe Leu Ser Ile 
        515                 520                 525             


Val Ala Arg His Ala Asp Asp Asn Ile Ser Lys Asp Gly Gln Glu Val 
    530                 535                 540                 


Xaa Gly Asn Lys Met Xaa Ser Leu Asn Leu Ala Xaa Ile Phe Gly Pro 
545                 550                 555                 560 


Asn Leu Leu His Lys Gln Lys Ser Ser Asp Lys Glu Phe Ser Val Gln 
                565                 570                 575     


Ser Ser Ala Arg Ala Glu Glu Ser Xaa Ala Ile Ile Ala Val Val Gln 
            580                 585                 590         


Lys Met Ile Glu Asn Tyr Glu Ala Leu Phe Met Val Pro Pro Asp Leu 
        595                 600                 605             


Gln Asn Glu Val Leu Ile Ser Leu Leu Glu Xaa Asp Pro Asp Val Val 
    610                 615                 620                 


Asp Tyr Leu Leu Arg Arg Lys Ala Ser Gln Ser Ser Ser Pro Asp Met 
625                 630                 635                 640 


Leu Gln Ser Glu Val Ser Phe Ser Val Gly Gly Arg His Ser Ser Xaa 
                645                 650                 655     


Asp Ser Asn Lys Ala Ser Ser Gly Asp Ile Ser Pro Tyr Asp Asn Asn 
            660                 665                 670         


Ser Pro Val Leu Ser Glu Arg Ser Leu Leu Ala Met Gln Glu Asp Ala 
        675                 680                 685             


Ala Pro Gly Gly Ser Glu Lys Leu Tyr Arg Val Pro Gly Gln Phe Met 
    690                 695                 700                 


Leu Val Gly His Leu Ser Ser Ser Lys Ser Arg Glu Ser Ser Pro Gly 
705                 710                 715                 720 


Pro Arg Leu Gly Lys Gly Asn Trp Ser Leu Ala Ser Arg Arg Trp Pro 
                725                 730                 735     


Lys Gln Ala Xaa Leu Leu Leu Leu His Val Ala Trp Cys Gly Ala Leu 
            740                 745                 750         


Arg Xaa Phe Ser Ser Ser Leu Pro Tyr Leu Met Phe Leu 
        755                 760                 765 


<210> 2903
<211> 974
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<400> 2903
Met Ser Ala Gln Ser Leu Leu His Ser Val Phe Ser Cys Ser Ser Pro 
1               5                   10                  15      


Ala Ser Ser Ser Ala Ala Ser Ala Lys Gly Phe Ser Lys Arg Lys Leu 
            20                  25                  30          


Arg Gln Xaa Arg Ser Leu Asp Pro Ala Leu Ile Gly Gly Cys Gly Ser 
        35                  40                  45              


Asp Glu Ala Gly Ala Glu Gly Ser Ala Arg Gly Ala Xaa Ala Gly Arg 
    50                  55                  60                  


Leu Tyr Ser Pro Ser Leu Pro Ala Glu Ser Leu Gly Pro Arg Leu Ala 
65                  70                  75                  80  


Ser Ser Ser Arg Gly Pro Pro Pro Arg Ala Xaa Arg Leu Pro Pro Pro 
                85                  90                  95      


Gly Pro Leu Cys Ser Ser Phe Ser Xaa Pro Ser Xaa Pro Gln Glu Lys 
            100                 105                 110         


Ser Pro Ser Gly Ser Phe His Phe Asp Tyr Glu Val Pro Leu Gly Arg 
        115                 120                 125             


Gly Gly Leu Lys Lys Ser Met Ala Trp Asp Leu Pro Ser Val Leu Ala 
    130                 135                 140                 


Gly Pro Ala Ser Ser Arg Ser Ala Ser Ser Ile Leu Cys Ser Ser Gly 
145                 150                 155                 160 


Gly Gly Pro Asn Gly Ile Phe Ala Ser Pro Arg Arg Trp Leu Gln Gln 
                165                 170                 175     


Arg Lys Phe Gln Ser Pro Pro Asp Ser Arg Gly His Pro Tyr Val Val 
            180                 185                 190         


Trp Lys Ser Glu Gly Asp Phe Xaa Trp Asn Ser Met Ser Gly Arg Ser 
        195                 200                 205             


Val Arg Leu Arg Ser Val Pro Ile Gln Ser Leu Ser Glu Leu Glu Arg 
    210                 215                 220                 


Ala Arg Leu Gln Glu Val Ala Phe Tyr Gln Leu Gln Gln Asp Cys Asp 
225                 230                 235                 240 


Leu Ser Cys Gln Ile Xaa Ile Pro Lys Asp Gly Gln Lys Arg Lys Lys 
                245                 250                 255     


Ser Leu Arg Lys Lys Leu Asp Ser Leu Gly Lys Glu Lys Asn Lys Asp 
            260                 265                 270         


Lys Glu Phe Ile Pro Gln Ala Phe Gly Met Pro Leu Ser Gln Val Ile 
        275                 280                 285             


Ala Asn Asp Arg Ala Tyr Lys Leu Lys Gln Asp Leu Gln Arg Asp Glu 
    290                 295                 300                 


Gln Lys Asp Ala Ser Asp Phe Val Ala Ser Leu Leu Pro Phe Gly Asn 
305                 310                 315                 320 


Lys Arg Gln Asn Lys Glu Leu Ser Ser Ser Asn Ser Ser Leu Ser Ser 
                325                 330                 335     


Xaa Ser Glu Xaa Pro Asn Glu Ser Xaa Ser Pro Asn Xaa Pro Glu Pro 
            340                 345                 350         


Ala Pro Arg Ala Arg Arg Arg Gly Ala Met Ser Val Asp Ser Ile Xaa 
        355                 360                 365             


Asp Leu Asp Asp Asn Gln Ser Arg Leu Leu Glu Ala Leu Gln Leu Ser 
    370                 375                 380                 


Leu Pro Ala Glu Ala Gln Ser Lys Lys Glu Lys Ala Arg Asp Lys Lys 
385                 390                 395                 400 


Leu Ser Leu Asn Pro Ile Tyr Arg Gln Val Pro Arg Leu Val Asp Ser 
                405                 410                 415     


Cys Cys Gln His Leu Glu Lys His Gly Leu Gln Xaa Val Gly Ile Phe 
            420                 425                 430         


Arg Val Gly Ser Ser Lys Lys Arg Val Arg Gln Leu Arg Glu Glu Phe 
        435                 440                 445             


Asp Arg Gly Ile Asp Val Ser Leu Glu Glu Glu His Ser Val His Asp 
    450                 455                 460                 


Val Ala Ala Leu Leu Lys Glu Phe Leu Arg Asp Met Pro Asp Pro Leu 
465                 470                 475                 480 


Leu Xaa Arg Glu Leu Tyr Xaa Ala Phe Ile Asn Xaa Leu Leu Leu Glu 
                485                 490                 495     


Pro Glu Glu Gln Leu Gly Xaa Leu Gln Leu Leu Ile Tyr Leu Leu Pro 
            500                 505                 510         


Pro Cys Asn Cys Asp Xaa Leu His Arg Leu Leu Gln Phe Leu Ser Ile 
        515                 520                 525             


Val Ala Arg His Ala Asp Asp Asn Ile Ser Lys Asp Gly Gln Glu Val 
    530                 535                 540                 


Xaa Gly Asn Lys Met Xaa Ser Leu Asn Leu Ala Xaa Ile Phe Gly Pro 
545                 550                 555                 560 


Asn Leu Leu His Lys Gln Lys Ser Ser Asp Lys Glu Phe Ser Val Gln 
                565                 570                 575     


Ser Ser Ala Arg Ala Glu Glu Ser Xaa Ala Ile Ile Ala Val Val Gln 
            580                 585                 590         


Lys Met Ile Glu Asn Tyr Glu Ala Leu Phe Met Val Pro Pro Asp Leu 
        595                 600                 605             


Gln Asn Glu Val Leu Ile Ser Leu Leu Glu Xaa Asp Pro Asp Val Val 
    610                 615                 620                 


Asp Tyr Leu Leu Arg Arg Lys Ala Ser Gln Ser Ser Ser Pro Asp Met 
625                 630                 635                 640 


Leu Gln Ser Glu Val Ser Phe Ser Val Gly Gly Arg His Ser Ser Xaa 
                645                 650                 655     


Asp Ser Asn Lys Ala Ser Ser Gly Asp Ile Ser Pro Tyr Asp Asn Asn 
            660                 665                 670         


Ser Pro Val Leu Ser Glu Arg Ser Leu Leu Ala Met Gln Glu Asp Ala 
        675                 680                 685             


Ala Pro Gly Gly Ser Glu Lys Leu Tyr Arg Val Pro Gly Gln Phe Met 
    690                 695                 700                 


Leu Val Gly His Leu Ser Ser Ser Lys Ser Arg Glu Ser Ser Pro Gly 
705                 710                 715                 720 


Pro Arg Leu Gly Lys Asp Leu Ser Glu Glu Pro Phe Asp Ile Trp Gly 
                725                 730                 735     


Xaa Trp His Ser Xaa Leu Lys Ser Gly Ser Lys Asp Pro Gly Met Xaa 
            740                 745                 750         


Gly Ser Ser Gly Asp Ile Phe Glu Ser Ser Ser Leu Arg Ala Gly Pro 
        755                 760                 765             


Cys Ser Leu Ser Gln Gly Asn Leu Ser Pro Asn Trp Pro Arg Trp Gln 
    770                 775                 780                 


Gly Ser Pro Ala Glu Leu Asp Ser Asp Xaa Gln Gly Ala Arg Arg Xaa 
785                 790                 795                 800 


Gln Ala Ala Ala Pro Ala Xaa Glu Gly Arg Ala His Pro Ala Val Ser 
                805                 810                 815     


Arg Ala Cys Ser Xaa Pro His Val Gln Val Ala Gly Lys Ala Glu Arg 
            820                 825                 830         


Pro Xaa Ala Arg Ser Glu Gln Tyr Leu Xaa Leu Ser Gly Ala His Asp 
        835                 840                 845             


Leu Ser Glu Ser Glu Leu Asp Val Ala Gly Leu Gln Ser Arg Ala Xaa 
    850                 855                 860                 


Pro Gln Cys Gln Arg Pro His Gly Ser Gly Arg Asp Asp Lys Arg Pro 
865                 870                 875                 880 


Pro Pro Pro Tyr Pro Gly Pro Gly Lys Pro Ala Ala Ala Ala Ala Trp 
                885                 890                 895     


Ile Gln Gly Pro Pro Glu Gly Val Glu Xaa Pro Xaa Asp Gln Gly Gly 
            900                 905                 910         


Gln Ala Ala Glu Arg Glu Gln Gln Val Xaa Gln Lys Lys Leu Ser Ser 
        915                 920                 925             


Ala Asn Ser Leu Pro Ala Gly Glu Gln Asp Ser Pro Arg Leu Gly Asp 
    930                 935                 940                 


Ala Gly Trp Leu Asp Trp Gln Arg Glu Arg Trp Gln Ile Trp Glu Leu 
945                 950                 955                 960 


Leu Ser Xaa Asp Asn Pro Asp Ala Leu Pro Glu Xaa Leu Val 
                965                 970                 


<210> 2904
<211> 690
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<400> 2904
Met Ser Ala Gln Ser Leu Leu His Ser Val Phe Ser Cys Ser Ser Pro 
1               5                   10                  15      


Ala Ser Ser Ser Ala Ala Ser Ala Lys Gly Phe Ser Lys Arg Lys Leu 
            20                  25                  30          


Arg Gln Xaa Arg Ser Leu Asp Pro Ala Leu Ile Gly Gly Cys Gly Ser 
        35                  40                  45              


Asp Glu Ala Gly Ala Glu Gly Ser Ala Arg Gly Ala Xaa Ala Gly Arg 
    50                  55                  60                  


Leu Tyr Ser Pro Ser Leu Pro Ala Glu Ser Leu Gly Pro Arg Leu Ala 
65                  70                  75                  80  


Ser Ser Ser Arg Gly Pro Pro Pro Arg Ala Xaa Arg Leu Pro Pro Pro 
                85                  90                  95      


Gly Pro Leu Cys Ser Ser Phe Ser Xaa Pro Ser Xaa Pro Gln Glu Lys 
            100                 105                 110         


Ser Pro Ser Gly Ser Phe His Phe Asp Tyr Glu Val Pro Leu Gly Arg 
        115                 120                 125             


Gly Gly Leu Lys Lys Ser Met Ala Trp Asp Leu Pro Ser Val Leu Ala 
    130                 135                 140                 


Gly Pro Ala Ser Ser Arg Ser Ala Ser Ser Ile Leu Cys Ser Ser Gly 
145                 150                 155                 160 


Gly Gly Pro Asn Gly Ile Phe Ala Ser Pro Arg Arg Trp Leu Gln Gln 
                165                 170                 175     


Arg Lys Phe Gln Ser Pro Pro Asp Ser Arg Gly His Pro Tyr Val Val 
            180                 185                 190         


Trp Lys Ser Glu Leu Glu Leu Tyr Asp Leu Gln Ile Leu Gly Xaa Lys 
        195                 200                 205             


Pro Pro Met Asn Ser Asp Xaa His Arg Asn Phe Asp Pro Xaa Ala Xaa 
    210                 215                 220                 


Leu Arg Asn Gln Gly Asp Phe Xaa Trp Asn Ser Met Ser Gly Arg Ser 
225                 230                 235                 240 


Val Arg Leu Arg Ser Val Pro Ile Gln Ser Leu Ser Glu Leu Glu Arg 
                245                 250                 255     


Ala Arg Leu Gln Glu Val Ala Phe Tyr Gln Leu Gln Gln Asp Cys Asp 
            260                 265                 270         


Leu Ser Cys Gln Ile Xaa Ile Pro Lys Asp Gly Gln Lys Arg Lys Lys 
        275                 280                 285             


Ser Leu Arg Lys Lys Leu Asp Ser Leu Gly Lys Glu Lys Asn Lys Asp 
    290                 295                 300                 


Lys Glu Phe Ile Pro Gln Ala Phe Gly Met Pro Leu Ser Gln Val Ile 
305                 310                 315                 320 


Ala Asn Asp Arg Ala Tyr Lys Leu Lys Gln Asp Leu Gln Arg Asp Glu 
                325                 330                 335     


Gln Lys Asp Ala Ser Asp Phe Val Ala Ser Leu Leu Pro Phe Gly Asn 
            340                 345                 350         


Lys Arg Gln Asn Lys Glu Leu Ser Ser Ser Asn Ser Ser Leu Ser Ser 
        355                 360                 365             


Xaa Ser Glu Xaa Pro Asn Glu Ser Xaa Ser Pro Asn Xaa Pro Glu Pro 
    370                 375                 380                 


Ala Pro Arg Ala Arg Arg Arg Gly Ala Met Ser Val Asp Ser Ile Xaa 
385                 390                 395                 400 


Asp Leu Asp Asp Asn Gln Ser Arg Leu Leu Glu Ala Leu Gln Leu Ser 
                405                 410                 415     


Leu Pro Ala Glu Ala Gln Ser Lys Lys Glu Lys Ala Arg Asp Lys Lys 
            420                 425                 430         


Leu Ser Leu Asn Pro Ile Tyr Arg Gln Val Pro Arg Leu Val Asp Ser 
        435                 440                 445             


Cys Cys Gln His Leu Glu Lys His Gly Leu Gln Xaa Val Gly Ile Phe 
    450                 455                 460                 


Arg Val Gly Ser Ser Lys Lys Arg Val Arg Gln Leu Arg Glu Glu Phe 
465                 470                 475                 480 


Asp Arg Gly Ile Asp Val Ser Leu Glu Glu Glu His Ser Val His Asp 
                485                 490                 495     


Val Ala Ala Leu Leu Lys Glu Phe Leu Arg Asp Met Pro Asp Pro Leu 
            500                 505                 510         


Leu Xaa Arg Glu Leu Tyr Xaa Ala Phe Ile Asn Xaa Leu Leu Leu Glu 
        515                 520                 525             


Pro Glu Glu Gln Leu Gly Xaa Leu Gln Leu Leu Ile Tyr Leu Leu Pro 
    530                 535                 540                 


Pro Cys Asn Cys Asp Xaa Leu His Arg Leu Leu Gln Phe Leu Ser Ile 
545                 550                 555                 560 


Val Ala Arg His Ala Asp Asp Asn Ile Ser Lys Asp Gly Gln Glu Val 
                565                 570                 575     


Xaa Gly Asn Lys Met Xaa Ser Leu Asn Leu Ala Xaa Ile Phe Gly Pro 
            580                 585                 590         


Asn Leu Leu His Lys Gln Lys Ser Ser Asp Lys Glu Phe Ser Val Gln 
        595                 600                 605             


Ser Ser Ala Arg Ala Glu Glu Ser Xaa Ala Ile Ile Ala Val Val Gln 
    610                 615                 620                 


Lys Met Ile Glu Asn Tyr Glu Ala Leu Phe Met Val Pro Pro Asp Leu 
625                 630                 635                 640 


Gln Asn Glu Val Leu Ile Ser Leu Leu Glu Xaa Asp Pro Asp Val Val 
                645                 650                 655     


Asp Tyr Leu Leu Arg Arg Lys Ala Ser Gln Ser Ser Xaa Ser Ser Val 
            660                 665                 670         


Leu Pro Ala Ala Val Gln Ala Cys Pro Gln Tyr Pro Ala Ser Met Phe 
        675                 680                 685             


Xaa Pro 
    690 


<210> 2905
<211> 771
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<400> 2905
Met Ser Gly Arg Ser Val Arg Leu Arg Ser Val Pro Ile Gln Ser Leu 
1               5                   10                  15      


Ser Glu Leu Glu Arg Ala Arg Leu Gln Glu Val Ala Phe Tyr Gln Leu 
            20                  25                  30          


Gln Gln Asp Cys Asp Leu Ser Cys Gln Ile Xaa Ile Pro Lys Asp Gly 
        35                  40                  45              


Gln Lys Arg Lys Lys Ser Leu Arg Lys Lys Leu Asp Ser Leu Gly Lys 
    50                  55                  60                  


Glu Lys Asn Lys Asp Lys Glu Phe Ile Pro Gln Ala Phe Gly Met Pro 
65                  70                  75                  80  


Leu Ser Gln Val Ile Ala Asn Asp Arg Ala Tyr Lys Leu Lys Gln Asp 
                85                  90                  95      


Leu Gln Arg Asp Glu Gln Lys Asp Ala Ser Asp Phe Val Ala Ser Leu 
            100                 105                 110         


Leu Pro Phe Gly Asn Lys Arg Gln Asn Lys Glu Leu Ser Ser Ser Asn 
        115                 120                 125             


Ser Ser Leu Ser Ser Xaa Ser Glu Xaa Pro Asn Glu Ser Xaa Ser Pro 
    130                 135                 140                 


Asn Xaa Pro Glu Pro Ala Pro Arg Ala Arg Arg Arg Gly Ala Met Ser 
145                 150                 155                 160 


Val Asp Ser Ile Xaa Asp Leu Asp Asp Asn Gln Ser Arg Leu Leu Glu 
                165                 170                 175     


Ala Leu Gln Leu Ser Leu Pro Ala Glu Ala Gln Ser Lys Lys Glu Lys 
            180                 185                 190         


Ala Arg Asp Lys Lys Leu Ser Leu Asn Pro Ile Tyr Arg Gln Val Pro 
        195                 200                 205             


Arg Leu Val Asp Ser Cys Cys Gln His Leu Glu Lys His Gly Leu Gln 
    210                 215                 220                 


Xaa Val Gly Ile Phe Arg Val Gly Ser Ser Lys Lys Arg Val Arg Gln 
225                 230                 235                 240 


Leu Arg Glu Glu Phe Asp Arg Gly Ile Asp Val Ser Leu Glu Glu Glu 
                245                 250                 255     


His Ser Val His Asp Val Ala Ala Leu Leu Lys Glu Phe Leu Arg Asp 
            260                 265                 270         


Met Pro Asp Pro Leu Leu Xaa Arg Glu Leu Tyr Xaa Ala Phe Ile Asn 
        275                 280                 285             


Xaa Leu Leu Leu Glu Pro Glu Glu Gln Leu Gly Xaa Leu Gln Leu Leu 
    290                 295                 300                 


Ile Tyr Leu Leu Pro Pro Cys Asn Cys Asp Xaa Leu His Arg Leu Leu 
305                 310                 315                 320 


Gln Phe Leu Ser Ile Val Ala Arg His Ala Asp Asp Asn Ile Ser Lys 
                325                 330                 335     


Asp Gly Gln Glu Val Xaa Gly Asn Lys Met Xaa Ser Leu Asn Leu Ala 
            340                 345                 350         


Xaa Ile Phe Gly Pro Asn Leu Leu His Lys Gln Lys Ser Ser Asp Lys 
        355                 360                 365             


Glu Phe Ser Val Gln Ser Ser Ala Arg Ala Glu Glu Ser Xaa Ala Ile 
    370                 375                 380                 


Ile Ala Val Val Gln Lys Met Ile Glu Asn Tyr Glu Ala Leu Phe Met 
385                 390                 395                 400 


Val Pro Pro Asp Leu Gln Asn Glu Val Leu Ile Ser Leu Leu Glu Xaa 
                405                 410                 415     


Asp Pro Asp Val Val Asp Tyr Leu Leu Arg Arg Lys Ala Ser Gln Ser 
            420                 425                 430         


Ser Ser Pro Asp Met Leu Gln Ser Glu Val Ser Phe Ser Val Gly Gly 
        435                 440                 445             


Arg His Ser Ser Xaa Asp Ser Asn Lys Ala Ser Ser Gly Asp Ile Ser 
    450                 455                 460                 


Pro Tyr Asp Asn Asn Ser Pro Val Leu Ser Glu Arg Ser Leu Leu Ala 
465                 470                 475                 480 


Met Gln Glu Asp Ala Ala Pro Gly Gly Ser Glu Lys Leu Tyr Arg Val 
                485                 490                 495     


Pro Gly Gln Phe Met Leu Val Gly His Leu Ser Ser Ser Lys Ser Arg 
            500                 505                 510         


Glu Ser Ser Pro Gly Pro Arg Leu Gly Lys Asp Leu Ser Glu Glu Pro 
        515                 520                 525             


Phe Asp Ile Trp Gly Xaa Trp His Ser Xaa Leu Lys Ser Gly Ser Lys 
    530                 535                 540                 


Asp Pro Gly Met Xaa Gly Ser Ser Gly Asp Ile Phe Glu Ser Ser Ser 
545                 550                 555                 560 


Leu Arg Ala Gly Pro Cys Ser Leu Ser Gln Gly Asn Leu Ser Pro Asn 
                565                 570                 575     


Trp Pro Arg Trp Gln Gly Ser Pro Ala Glu Leu Asp Ser Asp Xaa Gln 
            580                 585                 590         


Gly Ala Arg Arg Xaa Gln Ala Ala Ala Pro Ala Xaa Glu Gly Arg Ala 
        595                 600                 605             


His Pro Ala Val Ser Arg Ala Cys Ser Xaa Pro His Val Gln Val Ala 
    610                 615                 620                 


Gly Lys Ala Glu Arg Pro Xaa Ala Arg Ser Glu Gln Tyr Leu Xaa Leu 
625                 630                 635                 640 


Ser Gly Ala His Asp Leu Ser Glu Ser Glu Leu Asp Val Ala Gly Leu 
                645                 650                 655     


Gln Ser Arg Ala Xaa Pro Gln Cys Gln Arg Pro His Gly Ser Gly Arg 
            660                 665                 670         


Asp Asp Lys Arg Pro Pro Pro Pro Tyr Pro Gly Pro Gly Lys Pro Ala 
        675                 680                 685             


Ala Ala Ala Ala Trp Ile Gln Gly Pro Pro Glu Gly Val Glu Xaa Pro 
    690                 695                 700                 


Xaa Asp Gln Gly Gly Gln Ala Ala Glu Arg Glu Gln Gln Val Xaa Gln 
705                 710                 715                 720 


Lys Lys Leu Ser Ser Ala Asn Ser Leu Pro Ala Gly Glu Gln Asp Ser 
                725                 730                 735     


Pro Arg Leu Gly Asp Ala Gly Trp Leu Asp Trp Gln Arg Glu Arg Trp 
            740                 745                 750         


Gln Ile Trp Glu Leu Leu Ser Xaa Asp Asn Pro Asp Ala Leu Pro Glu 
        755                 760                 765             


Xaa Leu Val 
    770     


<210> 2906
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<400> 2906
Met Ala Gly Gln Asp Pro Ala Leu Ser Xaa Ser His Pro Phe Tyr Asp 
1               5                   10                  15      


Val Ala Arg His Gly Ile Leu Gln Val Ala Gly Asp Asp Arg Phe Gly 
            20                  25                  30          


Arg Arg Val Val Xaa Phe Ser Cys Cys Arg Met Pro Pro Ser His Glu 
        35                  40                  45              


Leu Asp His Gln Arg Leu Leu Glu Tyr Leu Lys Tyr Xaa Leu Asp Gln 
    50                  55                  60                  


Tyr Val Glu Asn Asp Tyr Xaa Ile Val Tyr Phe His Tyr Gly Leu Asn 
65                  70                  75                  80  


Ser Arg Asn Lys Pro Ser Leu Gly Trp Leu Gln Ser Ala Tyr Lys Glu 
                85                  90                  95      


Phe Asp Arg Lys Asp Gly Asp Leu Xaa Met Trp Pro Arg Leu Val Ser 
            100                 105                 110         


Asn Ser Lys Leu Lys Arg Ser Ser His Leu Ser Leu Pro Lys Tyr Trp 
        115                 120                 125             


Asp Tyr 
    130 


<210> 2907
<211> 464
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<400> 2907
Met Ala Gly Gln Asp Pro Ala Leu Ser Xaa Ser His Pro Phe Tyr Asp 
1               5                   10                  15      


Val Ala Arg His Gly Ile Leu Gln Val Ala Gly Asp Asp Arg Phe Gly 
            20                  25                  30          


Arg Arg Val Val Xaa Phe Ser Cys Cys Arg Met Pro Pro Ser His Glu 
        35                  40                  45              


Leu Asp His Gln Arg Leu Leu Glu Tyr Leu Lys Tyr Xaa Leu Asp Gln 
    50                  55                  60                  


Tyr Val Glu Asn Asp Tyr Xaa Ile Val Tyr Phe His Tyr Gly Leu Asn 
65                  70                  75                  80  


Ser Arg Asn Lys Pro Ser Leu Gly Trp Leu Gln Ser Ala Tyr Lys Glu 
                85                  90                  95      


Phe Asp Arg Lys Asp Gly Asp Leu Xaa Met Trp Pro Arg Leu Val Ser 
            100                 105                 110         


Asn Ser Lys Leu Lys Arg Ser Ser His Leu Ser Leu Pro Lys Tyr Trp 
        115                 120                 125             


Asp Tyr Arg Tyr Lys Lys Asn Leu Lys Ala Leu Tyr Val Val His Pro 
    130                 135                 140                 


Xaa Ser Phe Ile Lys Val Leu Trp Asn Ile Leu Lys Pro Leu Ile Ser 
145                 150                 155                 160 


His Lys Phe Gly Lys Lys Val Ile Tyr Phe Asn Tyr Leu Ser Glu Leu 
                165                 170                 175     


His Glu His Leu Lys Tyr Asp Gln Leu Val Ile Pro Pro Glu Val Leu 
            180                 185                 190         


Arg Tyr Asp Glu Lys Leu Gln Ser Leu His Glu Gly Arg Xaa Pro Pro 
        195                 200                 205             


Pro Xaa Lys Xaa Pro Pro Pro Arg Pro Pro Leu Pro Xaa Gln Gln Phe 
    210                 215                 220                 


Gly Val Ser Leu Gln Tyr Leu Lys Asp Lys Asn Gln Gly Glu Leu Ile 
225                 230                 235                 240 


Pro Pro Val Leu Arg Phe Xaa Val Xaa Tyr Leu Arg Glu Lys Gly Leu 
                245                 250                 255     


Arg Xaa Glu Gly Leu Phe Arg Arg Ser Ala Ser Val Gln Xaa Val Arg 
            260                 265                 270         


Glu Ile Gln Arg Leu Tyr Asn Gln Gly Lys Pro Val Asn Phe Asp Asp 
        275                 280                 285             


Tyr Gly Asp Ile His Ile Pro Ala Val Ile Leu Lys Xaa Phe Leu Arg 
    290                 295                 300                 


Glu Leu Pro Gln Pro Leu Leu Xaa Phe Gln Ala Tyr Glu Gln Ile Leu 
305                 310                 315                 320 


Gly Ile Xaa Cys Val Glu Ser Ser Leu Arg Val Xaa Gly Cys Arg Gln 
                325                 330                 335     


Ile Leu Arg Ser Leu Pro Glu His Asn Tyr Val Val Leu Arg Tyr Leu 
            340                 345                 350         


Met Gly Phe Leu His Ala Val Ser Arg Glu Ser Ile Phe Asn Lys Met 
        355                 360                 365             


Asn Ser Ser Asn Leu Ala Cys Val Phe Gly Leu Asn Leu Ile Trp Pro 
    370                 375                 380                 


Ser Gln Gly Val Ser Ser Leu Ser Ala Leu Val Pro Leu Asn Met Phe 
385                 390                 395                 400 


Xaa Glu Leu Leu Ile Glu Tyr Tyr Glu Lys Ile Phe Ser Xaa Pro Glu 
                405                 410                 415     


Ala Pro Gly Glu His Gly Leu Ala Pro Trp Glu Gln Gly Ser Arg Ala 
            420                 425                 430         


Ala Pro Leu Gln Glu Ala Val Pro Arg Xaa Gln Ala Xaa Gly Leu Xaa 
        435                 440                 445             


Lys Pro Xaa Leu Pro Pro Ser Pro Leu Met Ala Ala Arg Arg Arg Leu 
    450                 455                 460                 


<210> 2908
<211> 163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 2908
Met Ala Gly Gln Asp Pro Ala Leu Ser Xaa Ser His Pro Phe Tyr Asp 
1               5                   10                  15      


Val Ala Arg His Gly Ile Leu Gln Val Ala Gly Asp Asp Arg Phe Gly 
            20                  25                  30          


Arg Arg Val Val Xaa Phe Ser Cys Cys Arg Met Pro Pro Ser His Glu 
        35                  40                  45              


Leu Asp His Gln Arg Leu Leu Glu Tyr Leu Lys Tyr Xaa Leu Asp Gln 
    50                  55                  60                  


Tyr Val Glu Asn Asp Tyr Xaa Ile Val Tyr Phe His Tyr Gly Leu Asn 
65                  70                  75                  80  


Ser Arg Asn Lys Pro Ser Leu Gly Trp Leu Gln Ser Ala Tyr Lys Glu 
                85                  90                  95      


Phe Asp Arg Lys Asp Gly Leu Xaa Gln Pro Pro Trp Leu Xaa Pro Val 
            100                 105                 110         


Ile Pro Val Leu Trp Glu Ala Lys Val Gln Glu Glu Leu Glu Gly Pro 
        115                 120                 125             


Leu Arg Gly Ala Pro His Gln Leu His Gln Gly Pro Val Glu His Leu 
    130                 135                 140                 


Glu Ala Pro His Gln Ser Gln Val Trp Glu Glu Ser His Leu Phe Gln 
145                 150                 155                 160 


Leu Pro Glu 
            


<210> 2909
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<400> 2909
Met Ala Gly Gln Asp Pro Ala Leu Ser Xaa Ser His Pro Phe Tyr Asp 
1               5                   10                  15      


Val Ala Arg His Gly Ile Leu Gln Val Ala Gly Asp Asp Arg Phe Gly 
            20                  25                  30          


Arg Arg Val Val Xaa Phe Ser Cys Cys Arg Met Pro Pro Ser His Glu 
        35                  40                  45              


Leu Asp His Gln Arg Leu Leu Glu Tyr Leu Lys Tyr Xaa Leu Asp Gln 
    50                  55                  60                  


Tyr Val Glu Asn Asp Tyr Xaa Ile Val Tyr Phe His Tyr Gly Leu Asn 
65                  70                  75                  80  


Ser Arg Asn Lys Pro Ser Leu Gly Trp Leu Gln Ser Ala Tyr Lys Glu 
                85                  90                  95      


Phe Asp Arg Lys Tyr Lys Lys Asn Leu Lys Ala Leu Tyr Val Val His 
            100                 105                 110         


Pro Xaa Ser 
        115 


<210> 2910
<211> 305
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<400> 2910
Met Ala Gly Gln Asp Pro Ala Leu Ser Xaa Ser His Pro Phe Tyr Asp 
1               5                   10                  15      


Val Ala Arg His Gly Ile Leu Gln Val Ala Gly Asp Asp Arg Phe Gly 
            20                  25                  30          


Arg Arg Val Val Xaa Phe Ser Cys Cys Arg Met Pro Pro Ser His Glu 
        35                  40                  45              


Leu Asp His Gln Arg Leu Leu Glu Tyr Leu Lys Tyr Xaa Leu Asp Gln 
    50                  55                  60                  


Tyr Val Glu Asn Asp Tyr Xaa Ile Val Tyr Phe His Tyr Gly Leu Asn 
65                  70                  75                  80  


Ser Arg Asn Lys Pro Ser Leu Gly Trp Leu Gln Ser Ala Tyr Lys Glu 
                85                  90                  95      


Phe Asp Arg Lys Tyr Lys Lys Asn Leu Lys Ala Leu Tyr Val Val His 
            100                 105                 110         


Pro Xaa Ser Phe Ile Lys Val Leu Trp Asn Ile Leu Lys Pro Leu Ile 
        115                 120                 125             


Ser His Lys Phe Gly Lys Lys Val Ile Tyr Phe Asn Tyr Leu Ser Glu 
    130                 135                 140                 


Leu His Glu His Leu Lys Tyr Asp Gln Leu Val Ile Pro Pro Glu Val 
145                 150                 155                 160 


Leu Arg Tyr Asp Glu Lys Leu Gln Ser Leu His Glu Gly Arg Xaa Pro 
                165                 170                 175     


Pro Pro Xaa Lys Xaa Pro Pro Pro Arg Pro Pro Leu Pro Xaa Gln Gln 
            180                 185                 190         


Phe Gly Val Ser Leu Gln Tyr Leu Lys Asp Lys Asn Gln Gly Glu Leu 
        195                 200                 205             


Ile Pro Pro Val Leu Arg Phe Xaa Val Xaa Tyr Leu Arg Glu Lys Gly 
    210                 215                 220                 


Leu Arg Xaa Glu Gly Leu Phe Arg Arg Ser Ala Ser Val Gln Xaa Val 
225                 230                 235                 240 


Arg Glu Ile Gln Arg Leu Tyr Asn Gln Gly Lys Pro Val Asn Phe Asp 
                245                 250                 255     


Asp Tyr Gly Asp Ile His Ile Pro Ala Val Ile Leu Lys Xaa Phe Leu 
            260                 265                 270         


Arg Glu Leu Pro Gln Pro Leu Leu Xaa Phe Gln Ala Tyr Glu Gln Ile 
        275                 280                 285             


Leu Gly Ile Xaa Cys Val Pro Gly Glu His Leu Gln Gln Asn Glu Gln 
    290                 295                 300                 


Leu 
305 


<210> 2911
<211> 433
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<400> 2911
Met Ala Gly Gln Asp Pro Ala Leu Ser Xaa Ser His Pro Phe Tyr Asp 
1               5                   10                  15      


Val Ala Arg His Gly Ile Leu Gln Val Ala Gly Asp Asp Arg Phe Gly 
            20                  25                  30          


Arg Arg Val Val Xaa Phe Ser Cys Cys Arg Met Pro Pro Ser His Glu 
        35                  40                  45              


Leu Asp His Gln Arg Leu Leu Glu Tyr Leu Lys Tyr Xaa Leu Asp Gln 
    50                  55                  60                  


Tyr Val Glu Asn Asp Tyr Xaa Ile Val Tyr Phe His Tyr Gly Leu Asn 
65                  70                  75                  80  


Ser Arg Asn Lys Pro Ser Leu Gly Trp Leu Gln Ser Ala Tyr Lys Glu 
                85                  90                  95      


Phe Asp Arg Lys Tyr Lys Lys Asn Leu Lys Ala Leu Tyr Val Val His 
            100                 105                 110         


Pro Xaa Ser Phe Ile Lys Val Leu Trp Asn Ile Leu Lys Pro Leu Ile 
        115                 120                 125             


Ser His Lys Phe Gly Lys Lys Val Ile Tyr Phe Asn Tyr Leu Ser Glu 
    130                 135                 140                 


Leu His Glu His Leu Lys Tyr Asp Gln Leu Val Ile Pro Pro Glu Val 
145                 150                 155                 160 


Leu Arg Tyr Asp Glu Lys Leu Gln Ser Leu His Glu Gly Arg Xaa Pro 
                165                 170                 175     


Pro Pro Xaa Lys Xaa Pro Pro Pro Arg Pro Pro Leu Pro Xaa Gln Gln 
            180                 185                 190         


Phe Gly Val Ser Leu Gln Tyr Leu Lys Asp Lys Asn Gln Gly Glu Leu 
        195                 200                 205             


Ile Pro Pro Val Leu Arg Phe Xaa Val Xaa Tyr Leu Arg Glu Lys Gly 
    210                 215                 220                 


Leu Arg Xaa Glu Gly Leu Phe Arg Arg Ser Ala Ser Val Gln Xaa Val 
225                 230                 235                 240 


Arg Glu Ile Gln Arg Leu Tyr Asn Gln Gly Lys Pro Val Asn Phe Asp 
                245                 250                 255     


Asp Tyr Gly Asp Ile His Ile Pro Ala Val Ile Leu Lys Xaa Phe Leu 
            260                 265                 270         


Arg Glu Leu Pro Gln Pro Leu Leu Xaa Phe Gln Ala Tyr Glu Gln Ile 
        275                 280                 285             


Leu Gly Ile Xaa Cys Val Glu Ser Ser Leu Arg Val Xaa Gly Cys Arg 
    290                 295                 300                 


Gln Ile Leu Arg Ser Leu Pro Glu His Asn Tyr Val Val Leu Arg Tyr 
305                 310                 315                 320 


Leu Met Gly Phe Leu His Ala Val Ser Arg Glu Ser Ile Phe Asn Lys 
                325                 330                 335     


Met Asn Ser Ser Asn Leu Ala Cys Val Phe Gly Leu Asn Leu Ile Trp 
            340                 345                 350         


Pro Ser Gln Gly Val Ser Ser Leu Ser Ala Leu Val Pro Leu Asn Met 
        355                 360                 365             


Phe Xaa Glu Leu Leu Ile Glu Tyr Tyr Glu Lys Ile Phe Ser Xaa Pro 
    370                 375                 380                 


Glu Ala Pro Gly Glu His Gly Leu Ala Pro Trp Glu Gln Gly Ser Arg 
385                 390                 395                 400 


Ala Ala Pro Leu Gln Glu Ala Val Pro Arg Xaa Gln Ala Xaa Gly Leu 
                405                 410                 415     


Xaa Lys Pro Xaa Leu Pro Pro Ser Pro Leu Met Ala Ala Arg Arg Arg 
            420                 425                 430         


Leu 
    


<210> 2912
<211> 28
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<400> 2912
Met Ala Gly Gln Asp Pro Ala Leu Ser Xaa Ser His Pro Phe Tyr Asp 
1               5                   10                  15      


Val Ala Arg His Gly Ile Leu Gln Val Ala Gly Ile 
            20                  25              


<210> 2913
<211> 174
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<400> 2913
Met Gly Glu Gly Ala Gly Gly Gly Lys Ala Lys Arg Ser Met Gly Arg 
1               5                   10                  15      


Ala Xaa Gly Arg Met Xaa Xaa Ser Phe Phe Pro Leu Phe Trp Gln Ala 
            20                  25                  30          


Gly Pro Gln Pro Leu Met Ser Glu Pro Pro Val Tyr Cys Asn Leu Val 
        35                  40                  45              


Asp Leu Arg Arg Cys Pro Arg Ser Pro Pro Pro Gly Pro Ala Cys Pro 
    50                  55                  60                  


Leu Leu Gln Arg Leu Asp Ala Trp Glu Gln His Leu Asp Pro Asn Ser 
65                  70                  75                  80  


Gly Arg Cys Phe Tyr Ile Asn Ser Leu Xaa Gly Cys Lys Ser Trp Lys 
                85                  90                  95      


Pro Pro Arg Arg Ser Arg Ser Glu Xaa Asn Pro Gly Ser Met Glu Gly 
            100                 105                 110         


Xaa Gln Xaa Leu Lys Arg Asn Asn Asp Val Leu Gln Pro Gln Ala Lys 
        115                 120                 125             


Gly Phe Arg Ser Asp Xaa Gly Xaa Pro Glu Pro Leu Asp Pro Gln Gly 
    130                 135                 140                 


Ser Leu Ser Leu Ser Gln Arg Xaa Ser Gln Leu Asp Pro Pro Ala Leu 
145                 150                 155                 160 


Gln Ala Pro Arg Pro Leu Pro Gln Leu Leu Asp Asp Pro His 
                165                 170                 


<210> 2914
<211> 142
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<400> 2914
Met Ile Glu Glu Ser Ile Pro Ser Gln Ser Pro Xaa Xaa Val Ile Pro 
1               5                   10                  15      


Gly Gln Leu Leu Trp Xaa Pro Gly Pro Lys Leu Phe His Gly Ser Leu 
            20                  25                  30          


Glu Glu Leu Ser Gln Ala Leu Pro Ser Arg Ala Gln Ala Ser Ser Glu 
        35                  40                  45              


Gln Pro Pro Pro Leu Pro Arg Lys Met Cys Arg Ser Val Ser Xaa Asp 
    50                  55                  60                  


Asn Leu Ser Pro Ser Leu Leu Lys Pro Phe Gln Glu Gly Pro Ser Gly 
65                  70                  75                  80  


Arg Ser Leu Ser Gln Glu Asp Leu Pro Ser Glu Ala Ser Ala Ser Xaa 
                85                  90                  95      


Ala Gly Pro Gln Pro Leu Met Ser Glu Pro Pro Val Tyr Cys Asn Leu 
            100                 105                 110         


Val Asp Leu Arg Arg Cys Pro Arg Ser Pro Pro Pro Gly Pro Ala Cys 
        115                 120                 125             


Pro Leu Leu Gln Arg Leu Asp Ala Trp Glu Gln His Leu Asp 
    130                 135                 140         


<210> 2915
<211> 736
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<400> 2915
Met Ile Ser Ala Gln Cys Asn Leu Cys Leu Pro Gly Ser Ser Asp Ser 
1               5                   10                  15      


Cys Ala Ser Gly Ser Gln Val Ala Gly Xaa Xaa Val Ala Gly Pro Ala 
            20                  25                  30          


His Pro Glu Ser Leu Xaa Leu Cys Ser Gly Glu Ala Glu Arg Arg Gly 
        35                  40                  45              


Lys Glu Glu Trp Pro Asp Ser His His Tyr Pro Gly Pro Xaa Pro Ala 
    50                  55                  60                  


Pro Glu Ser Ser Asp Gly Pro His Lys Val Xaa Val Leu Ala Xaa Met 
65                  70                  75                  80  


Leu Ser Ser Arg Trp Trp Pro Ser Ser Trp Gly Ile Leu Gly Leu Gly 
                85                  90                  95      


Pro Arg Ser Pro Pro Arg Gly Ser Gln Leu Cys Ala Leu Tyr Ala Phe 
            100                 105                 110         


Xaa Tyr Xaa Gly Ala Asp Gly Gln Gln Val Ser Leu Ala Glu Gly Asp 
        115                 120                 125             


Arg Phe Leu Leu Leu Arg Lys Xaa Asn Ser Asp Trp Trp Leu Ala Arg 
    130                 135                 140                 


Arg Leu Glu Ala Pro Ser Xaa Ser Arg Pro Ile Phe Val Pro Ala Ala 
145                 150                 155                 160 


Tyr Met Ile Glu Glu Ser Ile Pro Ser Gln Ser Pro Xaa Xaa Val Ile 
                165                 170                 175     


Pro Gly Gln Leu Leu Trp Xaa Pro Gly Pro Lys Leu Phe His Gly Ser 
            180                 185                 190         


Leu Glu Glu Leu Ser Gln Ala Leu Pro Ser Arg Ala Gln Ala Ser Ser 
        195                 200                 205             


Glu Gln Pro Pro Pro Leu Pro Arg Lys Met Cys Arg Ser Val Ser Xaa 
    210                 215                 220                 


Asp Asn Leu Ser Pro Ser Leu Leu Lys Pro Phe Gln Glu Gly Pro Ser 
225                 230                 235                 240 


Gly Arg Ser Leu Ser Gln Glu Asp Leu Pro Ser Glu Ala Ser Ala Ser 
                245                 250                 255     


Xaa Ala Gly Pro Gln Pro Leu Met Ser Glu Pro Pro Val Tyr Cys Asn 
            260                 265                 270         


Leu Val Asp Leu Arg Arg Cys Pro Arg Ser Pro Pro Pro Gly Pro Ala 
        275                 280                 285             


Cys Pro Leu Leu Gln Arg Leu Asp Ala Trp Glu Gln His Leu Asp Pro 
    290                 295                 300                 


Asn Ser Gly Arg Cys Phe Tyr Ile Asn Ser Leu Xaa Gly Cys Lys Ser 
305                 310                 315                 320 


Trp Lys Pro Pro Arg Arg Ser Arg Ser Glu Xaa Asn Pro Gly Ser Met 
                325                 330                 335     


Glu Gly Xaa Gln Xaa Leu Lys Arg Asn Asn Asp Val Leu Gln Pro Gln 
            340                 345                 350         


Ala Lys Gly Phe Arg Ser Asp Xaa Gly Xaa Pro Glu Pro Leu Asp Pro 
        355                 360                 365             


Gln Gly Ser Leu Ser Leu Ser Gln Arg Xaa Ser Gln Leu Asp Pro Pro 
    370                 375                 380                 


Ala Leu Gln Ala Pro Arg Pro Leu Pro Gln Leu Leu Asp Asp Pro His 
385                 390                 395                 400 


Glu Val Glu Lys Ser Gly Leu Leu Asn Met Xaa Lys Ile Ala Gln Gly 
                405                 410                 415     


Gly Arg Lys Leu Arg Lys Asn Trp Gly Pro Ser Trp Val Val Leu Xaa 
            420                 425                 430         


Gly Asn Ser Leu Val Phe Tyr Arg Glu Pro Pro Pro Xaa Ala Pro Ser 
        435                 440                 445             


Ser Gly Trp Gly Pro Ala Gly Ser Arg Pro Glu Ser Ser Val Asp Leu 
    450                 455                 460                 


Arg Gly Ala Ala Leu Ala His Gly Arg His Leu Ser Ser Arg Arg Asn 
465                 470                 475                 480 


Val Leu His Ile Arg Xaa Ile Pro Gly His Glu Phe Leu Leu Gln Ser 
                485                 490                 495     


Asp His Glu Xaa Glu Leu Arg Ala Trp His Arg Ala Leu Arg Xaa Val 
            500                 505                 510         


Ile Glu Arg Leu Asp Arg Glu Asn Pro Leu Glu Leu Arg Leu Ser Gly 
        515                 520                 525             


Ser Gly Pro Ala Glu Leu Ser Ala Gly Glu Asp Glu Glu Glu Glu Ser 
    530                 535                 540                 


Glu Leu Val Ser Lys Pro Leu Leu Arg Leu Ser Ser Arg Arg Ser Ser 
545                 550                 555                 560 


Ile Arg Gly Pro Glu Gly Xaa Glu Gln Asn Arg Val Arg Asn Lys Leu 
                565                 570                 575     


Lys Arg Leu Ile Ala Lys Arg Pro Pro Leu Gln Ser Leu Gln Glu Arg 
            580                 585                 590         


Gly Leu Leu Arg Asp Gln Val Phe Gly Cys Gln Leu Glu Ser Leu Cys 
        595                 600                 605             


Gln Arg Glu Gly Asp Xaa Val Pro Ser Phe Leu Arg Leu Cys Ile Ala 
    610                 615                 620                 


Ala Val Asp Lys Arg Gly Leu Asp Val Asp Gly Ile Tyr Arg Val Ser 
625                 630                 635                 640 


Gly Asn Leu Ala Val Val Gln Lys Leu Arg Phe Leu Val Asp Arg Glu 
                645                 650                 655     


Arg Ala Val Xaa Ser Asp Gly Arg Tyr Val Phe Pro Glu Gln Pro Gly 
            660                 665                 670         


Gln Glu Gly Arg Leu Asp Leu Asp Ser Xaa Glu Trp Asp Asp Ile His 
        675                 680                 685             


Val Val Xaa Gly Ala Leu Lys Leu Phe Leu Arg Glu Leu Pro Gln Pro 
    690                 695                 700                 


Leu Val Pro Pro Leu Leu Leu Pro His Phe Arg Ala Ala Leu Ala Val 
705                 710                 715                 720 


Pro Leu Ser Asp Xaa Arg Ile Asn Arg Leu Asn Ala Lys Ala Gln Pro 
                725                 730                 735     


<210> 2916
<211> 640
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<400> 2916
Met Leu Ser Ser Arg Trp Trp Pro Ser Ser Trp Gly Ile Leu Gly Leu 
1               5                   10                  15      


Gly Pro Arg Ser Pro Pro Arg Gly Ser Gln Leu Cys Ala Leu Tyr Ala 
            20                  25                  30          


Phe Xaa Tyr Xaa Gly Ala Asp Gly Gln Gln Val Ser Leu Ala Glu Gly 
        35                  40                  45              


Asp Arg Phe Leu Leu Leu Arg Lys Xaa Asn Ser Asp Trp Trp Leu Ala 
    50                  55                  60                  


Arg Arg Leu Glu Ala Pro Ser Xaa Ser Arg Pro Ile Phe Val Pro Ala 
65                  70                  75                  80  


Ala Tyr Met Ile Glu Glu Ser Ile Pro Ser Gln Ser Pro Xaa Xaa Val 
                85                  90                  95      


Ile Pro Gly Gln Leu Leu Trp Xaa Pro Gly Pro Lys Leu Phe His Gly 
            100                 105                 110         


Ser Leu Glu Glu Leu Ser Gln Ala Leu Pro Ser Arg Ala Gln Ala Ser 
        115                 120                 125             


Ser Glu Gln Pro Pro Pro Leu Pro Arg Lys Met Cys Arg Ser Val Ser 
    130                 135                 140                 


Xaa Asp Asn Leu Ser Pro Ser Leu Leu Lys Pro Phe Gln Glu Gly Pro 
145                 150                 155                 160 


Ser Gly Arg Ser Leu Ser Gln Glu Asp Leu Pro Ser Glu Ala Ser Ala 
                165                 170                 175     


Ser Xaa Ala Gly Pro Gln Pro Leu Met Ser Glu Pro Pro Val Tyr Cys 
            180                 185                 190         


Asn Leu Val Asp Leu Arg Arg Cys Pro Arg Ser Pro Pro Pro Gly Pro 
        195                 200                 205             


Ala Cys Pro Leu Leu Gln Arg Leu Asp Ala Trp Glu Gln His Leu Asp 
    210                 215                 220                 


Pro Asn Ser Gly Arg Cys Phe Tyr Ile Asn Ser Leu Xaa Gly Cys Lys 
225                 230                 235                 240 


Ser Trp Lys Pro Pro Arg Arg Ser Arg Ser Glu Xaa Asn Pro Gly Ser 
                245                 250                 255     


Met Glu Gly Xaa Gln Xaa Leu Lys Arg Asn Asn Asp Val Leu Gln Pro 
            260                 265                 270         


Gln Ala Lys Gly Phe Arg Ser Asp Xaa Gly Xaa Pro Glu Pro Leu Asp 
        275                 280                 285             


Pro Gln Gly Ser Leu Ser Leu Ser Gln Arg Xaa Ser Gln Leu Asp Pro 
    290                 295                 300                 


Pro Ala Leu Gln Ala Pro Arg Pro Leu Pro Gln Leu Leu Asp Asp Pro 
305                 310                 315                 320 


His Glu Val Glu Lys Ser Gly Leu Leu Asn Met Xaa Lys Ile Ala Gln 
                325                 330                 335     


Gly Gly Arg Lys Leu Arg Lys Asn Trp Gly Pro Ser Trp Val Val Leu 
            340                 345                 350         


Xaa Gly Asn Ser Leu Val Phe Tyr Arg Glu Pro Pro Pro Xaa Ala Pro 
        355                 360                 365             


Ser Ser Gly Trp Gly Pro Ala Gly Ser Arg Pro Glu Ser Ser Val Asp 
    370                 375                 380                 


Leu Arg Gly Ala Ala Leu Ala His Gly Arg His Leu Ser Ser Arg Arg 
385                 390                 395                 400 


Asn Val Leu His Ile Arg Xaa Ile Pro Gly His Glu Phe Leu Leu Gln 
                405                 410                 415     


Ser Asp His Glu Xaa Glu Leu Arg Ala Trp His Arg Ala Leu Arg Xaa 
            420                 425                 430         


Val Ile Glu Arg Leu Asp Arg Glu Asn Pro Leu Glu Leu Arg Leu Ser 
        435                 440                 445             


Gly Ser Gly Pro Ala Glu Leu Ser Ala Gly Glu Asp Glu Glu Glu Glu 
    450                 455                 460                 


Ser Glu Leu Val Ser Lys Pro Leu Leu Arg Leu Ser Ser Arg Arg Ser 
465                 470                 475                 480 


Ser Ile Arg Gly Pro Glu Gly Xaa Glu Gln Asn Arg Val Arg Asn Lys 
                485                 490                 495     


Leu Lys Arg Leu Ile Ala Lys Arg Pro Pro Leu Gln Ser Leu Gln Glu 
            500                 505                 510         


Arg Gly Leu Leu Arg Asp Gln Val Phe Gly Cys Gln Leu Glu Ser Leu 
        515                 520                 525             


Cys Gln Arg Glu Gly Asp Xaa Val Pro Ser Phe Leu Arg Leu Cys Ile 
    530                 535                 540                 


Ala Ala Val Asp Lys Arg Gly Leu Asp Val Asp Gly Ile Tyr Arg Val 
545                 550                 555                 560 


Ser Gly Asn Leu Ala Val Val Gln Lys Leu Arg Phe Leu Val Asp Arg 
                565                 570                 575     


Glu Arg Ala Val Xaa Ser Asp Gly Arg Tyr Val Phe Pro Glu Gln Pro 
            580                 585                 590         


Gly Gln Glu Gly Arg Leu Asp Leu Asp Ser Xaa Glu Trp Asp Asp Ile 
        595                 600                 605             


His Val Val Xaa Gly Ala Leu Lys Leu Phe Leu Arg Glu Leu Pro Gln 
    610                 615                 620                 


Pro Leu Val Pro Pro Leu Leu Leu Pro His Phe Arg Ala Ala Leu Gly 
625                 630                 635                 640 


<210> 2917
<211> 731
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<400> 2917
Met Leu Ser Ser Arg Trp Trp Pro Ser Ser Trp Gly Ile Leu Gly Leu 
1               5                   10                  15      


Gly Pro Arg Ser Pro Pro Arg Gly Ser Gln Leu Cys Ala Leu Tyr Ala 
            20                  25                  30          


Phe Xaa Tyr Xaa Gly Ala Asp Gly Gln Gln Val Ser Leu Ala Glu Gly 
        35                  40                  45              


Asp Arg Phe Leu Leu Leu Arg Lys Xaa Asn Ser Asp Trp Trp Leu Ala 
    50                  55                  60                  


Arg Arg Leu Glu Ala Pro Ser Xaa Ser Arg Pro Ile Phe Val Pro Ala 
65                  70                  75                  80  


Ala Tyr Met Ile Glu Glu Ser Ile Pro Ser Gln Ser Pro Xaa Xaa Val 
                85                  90                  95      


Ile Pro Gly Gln Leu Leu Trp Xaa Pro Gly Pro Lys Leu Phe His Gly 
            100                 105                 110         


Ser Leu Glu Glu Leu Ser Gln Ala Leu Pro Ser Arg Ala Gln Ala Ser 
        115                 120                 125             


Ser Glu Gln Pro Pro Pro Leu Pro Arg Lys Met Cys Arg Ser Val Ser 
    130                 135                 140                 


Xaa Asp Asn Leu Ser Pro Ser Leu Leu Lys Pro Phe Gln Glu Gly Pro 
145                 150                 155                 160 


Ser Gly Arg Ser Leu Ser Gln Glu Asp Leu Pro Ser Glu Ala Ser Ala 
                165                 170                 175     


Ser Xaa Ala Gly Pro Gln Pro Leu Met Ser Glu Pro Pro Val Tyr Cys 
            180                 185                 190         


Asn Leu Val Asp Leu Arg Arg Cys Pro Arg Ser Pro Pro Pro Gly Pro 
        195                 200                 205             


Ala Cys Pro Leu Leu Gln Arg Leu Asp Ala Trp Glu Gln His Leu Asp 
    210                 215                 220                 


Pro Asn Ser Gly Arg Cys Phe Tyr Ile Asn Ser Leu Xaa Gly Cys Lys 
225                 230                 235                 240 


Ser Trp Lys Pro Pro Arg Arg Ser Arg Ser Glu Xaa Asn Pro Gly Ser 
                245                 250                 255     


Met Glu Gly Xaa Gln Xaa Leu Lys Arg Asn Asn Asp Val Leu Gln Pro 
            260                 265                 270         


Gln Ala Lys Gly Phe Arg Ser Asp Xaa Gly Xaa Pro Glu Pro Leu Asp 
        275                 280                 285             


Pro Gln Gly Ser Leu Ser Leu Ser Gln Arg Xaa Ser Gln Leu Asp Pro 
    290                 295                 300                 


Pro Ala Leu Gln Ala Pro Arg Pro Leu Pro Gln Leu Leu Asp Asp Pro 
305                 310                 315                 320 


His Glu Val Glu Lys Ser Gly Leu Leu Asn Met Xaa Lys Ile Ala Gln 
                325                 330                 335     


Gly Gly Arg Lys Leu Arg Lys Asn Trp Gly Pro Ser Trp Val Val Leu 
            340                 345                 350         


Xaa Gly Asn Ser Leu Val Phe Tyr Arg Glu Pro Pro Pro Xaa Ala Pro 
        355                 360                 365             


Ser Ser Gly Trp Gly Pro Ala Gly Ser Arg Pro Glu Ser Ser Val Asp 
    370                 375                 380                 


Leu Arg Gly Ala Ala Leu Ala His Gly Arg His Leu Ser Ser Arg Arg 
385                 390                 395                 400 


Asn Val Leu His Ile Arg Xaa Ile Pro Gly His Glu Phe Leu Leu Gln 
                405                 410                 415     


Ser Asp His Glu Xaa Glu Leu Arg Ala Trp His Arg Ala Leu Arg Xaa 
            420                 425                 430         


Val Ile Glu Arg Leu Asp Arg Glu Asn Pro Leu Glu Leu Arg Leu Ser 
        435                 440                 445             


Gly Ser Gly Pro Ala Glu Leu Ser Ala Gly Glu Asp Glu Glu Glu Glu 
    450                 455                 460                 


Ser Glu Leu Val Ser Lys Pro Leu Leu Arg Leu Ser Ser Arg Arg Ser 
465                 470                 475                 480 


Ser Ile Arg Gly Pro Glu Gly Xaa Glu Gln Asn Arg Val Arg Asn Lys 
                485                 490                 495     


Leu Lys Arg Leu Ile Ala Lys Arg Pro Pro Leu Gln Ser Leu Gln Glu 
            500                 505                 510         


Arg Gly Leu Leu Arg Asp Gln Val Phe Gly Cys Gln Leu Glu Ser Leu 
        515                 520                 525             


Cys Gln Arg Glu Gly Asp Xaa Val Pro Ser Phe Leu Arg Leu Cys Ile 
    530                 535                 540                 


Ala Ala Val Asp Lys Arg Gly Leu Asp Val Asp Gly Ile Tyr Arg Val 
545                 550                 555                 560 


Ser Gly Asn Leu Ala Val Val Gln Lys Leu Arg Phe Leu Val Asp Arg 
                565                 570                 575     


Glu Arg Ala Val Xaa Ser Asp Gly Arg Tyr Val Phe Pro Glu Gln Pro 
            580                 585                 590         


Gly Gln Glu Gly Arg Leu Asp Leu Asp Ser Xaa Glu Trp Asp Asp Ile 
        595                 600                 605             


His Val Val Xaa Gly Ala Leu Lys Leu Phe Leu Arg Glu Leu Pro Gln 
    610                 615                 620                 


Pro Leu Val Pro Pro Leu Leu Leu Pro His Phe Arg Ala Ala Leu Ala 
625                 630                 635                 640 


Leu Ser Glu Ser Glu Gln Cys Leu Ser Gln Ile Gln Glu Leu Ile Gly 
                645                 650                 655     


Ser Met Pro Lys Pro Asn His Asp Xaa Leu Arg Tyr Leu Leu Glu His 
            660                 665                 670         


Leu Cys Arg Val Ile Ala His Ser Asp Lys Asn Arg Met Xaa Pro His 
        675                 680                 685             


Asn Leu Gly Ile Val Phe Gly Pro Xaa Leu Phe Arg Pro Glu Gln Glu 
    690                 695                 700                 


Xaa Ser Asp Pro Ala Ala His Ala Leu Tyr Pro Gly Gln Leu Val Gln 
705                 710                 715                 720 


Leu Met Leu Xaa Asn Phe Xaa Ser Leu Phe Pro 
                725                 730     


<210> 2918
<211> 821
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<400> 2918
Met Arg Arg Gly Ser Ser Asp Ser Cys Ala Ser Gly Ser Gln Val Ala 
1               5                   10                  15      


Gly Xaa Xaa Val Ala Gly Pro Ala His Pro Glu Ser Leu Xaa Leu Cys 
            20                  25                  30          


Ser Gly Glu Ala Glu Arg Arg Gly Lys Glu Glu Trp Pro Asp Ser His 
        35                  40                  45              


His Tyr Pro Gly Pro Xaa Pro Ala Pro Glu Ser Ser Asp Gly Pro His 
    50                  55                  60                  


Lys Val Xaa Val Leu Ala Xaa Met Leu Ser Ser Arg Trp Trp Pro Ser 
65                  70                  75                  80  


Ser Trp Gly Ile Leu Gly Leu Gly Pro Arg Ser Pro Pro Arg Gly Ser 
                85                  90                  95      


Gln Leu Cys Ala Leu Tyr Ala Phe Xaa Tyr Xaa Gly Ala Asp Gly Gln 
            100                 105                 110         


Gln Val Ser Leu Ala Glu Gly Asp Arg Phe Leu Leu Leu Arg Lys Xaa 
        115                 120                 125             


Asn Ser Asp Trp Trp Leu Ala Arg Arg Leu Glu Ala Pro Ser Xaa Ser 
    130                 135                 140                 


Arg Pro Ile Phe Val Pro Ala Ala Tyr Met Ile Glu Glu Ser Ile Pro 
145                 150                 155                 160 


Ser Gln Ser Pro Xaa Xaa Val Ile Pro Gly Gln Leu Leu Trp Xaa Pro 
                165                 170                 175     


Gly Pro Lys Leu Phe His Gly Ser Leu Glu Glu Leu Ser Gln Ala Leu 
            180                 185                 190         


Pro Ser Arg Ala Gln Ala Ser Ser Glu Gln Pro Pro Pro Leu Pro Arg 
        195                 200                 205             


Lys Met Cys Arg Ser Val Ser Xaa Asp Asn Leu Ser Pro Ser Leu Leu 
    210                 215                 220                 


Lys Pro Phe Gln Glu Gly Pro Ser Gly Arg Ser Leu Ser Gln Glu Asp 
225                 230                 235                 240 


Leu Pro Ser Glu Ala Ser Ala Ser Xaa Ala Gly Pro Gln Pro Leu Met 
                245                 250                 255     


Ser Glu Pro Pro Val Tyr Cys Asn Leu Val Asp Leu Arg Arg Cys Pro 
            260                 265                 270         


Arg Ser Pro Pro Pro Gly Pro Ala Cys Pro Leu Leu Gln Arg Leu Asp 
        275                 280                 285             


Ala Trp Glu Gln His Leu Asp Pro Asn Ser Gly Arg Cys Phe Tyr Ile 
    290                 295                 300                 


Asn Ser Leu Xaa Gly Cys Lys Ser Trp Lys Pro Pro Arg Arg Ser Arg 
305                 310                 315                 320 


Ser Glu Xaa Asn Pro Gly Ser Met Glu Gly Xaa Gln Xaa Leu Lys Arg 
                325                 330                 335     


Asn Asn Asp Val Leu Gln Pro Gln Ala Lys Gly Phe Arg Ser Asp Xaa 
            340                 345                 350         


Gly Xaa Pro Glu Pro Leu Asp Pro Gln Gly Ser Leu Ser Leu Ser Gln 
        355                 360                 365             


Arg Xaa Ser Gln Leu Asp Pro Pro Ala Leu Gln Ala Pro Arg Pro Leu 
    370                 375                 380                 


Pro Gln Leu Leu Asp Asp Pro His Glu Val Glu Lys Ser Gly Leu Leu 
385                 390                 395                 400 


Asn Met Xaa Lys Ile Ala Gln Gly Gly Arg Lys Leu Arg Lys Asn Trp 
                405                 410                 415     


Gly Pro Ser Trp Val Val Leu Xaa Gly Asn Ser Leu Val Phe Tyr Arg 
            420                 425                 430         


Glu Pro Pro Pro Xaa Ala Pro Ser Ser Gly Trp Gly Pro Ala Gly Ser 
        435                 440                 445             


Arg Pro Glu Ser Ser Val Asp Leu Arg Gly Ala Ala Leu Ala His Gly 
    450                 455                 460                 


Arg His Leu Ser Ser Arg Arg Asn Val Leu His Ile Arg Xaa Ile Pro 
465                 470                 475                 480 


Gly His Glu Phe Leu Leu Gln Ser Asp His Glu Xaa Glu Leu Arg Ala 
                485                 490                 495     


Trp His Arg Ala Leu Arg Xaa Val Ile Glu Arg Leu Val Arg Trp Val 
            500                 505                 510         


Glu Ala Arg Arg Glu Ala Pro Xaa Gly Arg Asp Gln Gly Ser Gly Asp 
        515                 520                 525             


Arg Glu Asn Pro Leu Glu Leu Arg Leu Ser Gly Ser Gly Pro Ala Glu 
    530                 535                 540                 


Leu Ser Ala Gly Glu Asp Glu Glu Glu Glu Ser Glu Leu Val Ser Lys 
545                 550                 555                 560 


Pro Leu Leu Arg Leu Ser Ser Arg Arg Ser Ser Ile Arg Gly Pro Glu 
                565                 570                 575     


Gly Xaa Glu Gln Asn Arg Val Arg Asn Lys Leu Lys Arg Leu Ile Ala 
            580                 585                 590         


Lys Arg Pro Pro Leu Gln Ser Leu Gln Glu Arg Gly Leu Leu Arg Asp 
        595                 600                 605             


Gln Val Phe Gly Cys Gln Leu Glu Ser Leu Cys Gln Arg Glu Gly Asp 
    610                 615                 620                 


Xaa Val Pro Ser Phe Leu Arg Leu Cys Ile Ala Ala Val Asp Lys Arg 
625                 630                 635                 640 


Gly Leu Asp Val Asp Gly Ile Tyr Arg Val Ser Gly Asn Leu Ala Val 
                645                 650                 655     


Val Gln Lys Leu Arg Phe Leu Val Asp Arg Glu Arg Ala Val Xaa Ser 
            660                 665                 670         


Asp Gly Arg Tyr Val Phe Pro Glu Gln Pro Gly Gln Glu Gly Arg Leu 
        675                 680                 685             


Asp Leu Asp Ser Xaa Glu Trp Asp Asp Ile His Val Val Xaa Gly Ala 
    690                 695                 700                 


Leu Lys Leu Phe Leu Arg Glu Leu Pro Gln Pro Leu Val Pro Pro Leu 
705                 710                 715                 720 


Leu Leu Pro His Phe Arg Ala Ala Leu Ala Leu Ser Glu Ser Glu Gln 
                725                 730                 735     


Cys Leu Ser Gln Ile Gln Glu Leu Ile Gly Ser Met Pro Lys Pro Asn 
            740                 745                 750         


His Asp Xaa Leu Arg Tyr Leu Leu Glu His Leu Cys Arg Val Ile Ala 
        755                 760                 765             


His Ser Asp Lys Asn Arg Met Xaa Pro His Asn Leu Gly Ile Val Phe 
    770                 775                 780                 


Gly Pro Xaa Leu Phe Arg Pro Glu Gln Glu Xaa Ser Asp Pro Ala Ala 
785                 790                 795                 800 


His Ala Leu Tyr Pro Gly Gln Leu Val Gln Leu Met Leu Xaa Asn Phe 
                805                 810                 815     


Xaa Ser Leu Phe Pro 
            820     


<210> 2919
<211> 61
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 2919
Met Ser Glu Pro Pro Val Tyr Cys Asn Leu Val Asp Leu Arg Arg Cys 
1               5                   10                  15      


Pro Arg Ser Pro Pro Pro Gly Pro Ala Cys Pro Leu Leu Gln Arg Leu 
            20                  25                  30          


Asp Ala Trp Glu Gln His Leu Asp Pro Asn Ser Gly Arg Cys Phe Tyr 
        35                  40                  45              


Ile Asn Ser Leu Xaa Gly Cys Lys Ser Trp Lys Pro Pro 
    50                  55                  60      


<210> 2920
<211> 153
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<400> 2920
Met Ser Glu Pro Pro Val Tyr Cys Asn Leu Val Asp Leu Arg Arg Cys 
1               5                   10                  15      


Pro Arg Ser Pro Pro Pro Gly Pro Ala Cys Pro Leu Leu Gln Arg Leu 
            20                  25                  30          


Asp Ala Trp Glu Gln His Leu Asp Pro Asn Ser Gly Arg Cys Phe Tyr 
        35                  40                  45              


Ile Asn Ser Leu Xaa Gly Cys Lys Ser Trp Lys Pro Pro Arg Arg Ser 
    50                  55                  60                  


Arg Ser Glu Xaa Asn Pro Gly Ser Met Glu Gly Xaa Gln Xaa Leu Lys 
65                  70                  75                  80  


Arg Asn Asn Asp Val Leu Gln Pro Gln Ala Lys Gly Phe Arg Ser Asp 
                85                  90                  95      


Xaa Gly Xaa Pro Glu Pro Leu Asp Pro Gln Glu Val Glu Lys Ser Gly 
            100                 105                 110         


Leu Leu Asn Met Xaa Lys Ile Ala Gln Gly Gly Arg Lys Leu Arg Lys 
        115                 120                 125             


Asn Trp Gly Pro Ser Trp Val Val Leu Xaa Gly Asn Ser Leu Val Phe 
    130                 135                 140                 


Tyr Arg Glu Pro Pro Pro Xaa Ala Pro 
145                 150             


<210> 2921
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 2921
Met Ser Glu Pro Pro Val Tyr Cys Asn Leu Val Asp Leu Arg Arg Cys 
1               5                   10                  15      


Pro Arg Ser Pro Pro Pro Gly Pro Ala Cys Pro Leu Leu Gln Arg Leu 
            20                  25                  30          


Asp Ala Trp Glu Gln His Leu Asp Pro Asn Ser Gly Arg Cys Phe Tyr 
        35                  40                  45              


Ile Asn Ser Leu Xaa Gly Cys Lys Ser Trp Lys Pro Pro Arg Arg Ser 
    50                  55                  60                  


Arg Ser Glu Xaa Asn Pro Gly Ser Met Glu Gly Xaa Gln Xaa Leu Lys 
65                  70                  75                  80  


Arg Asn Asn Asp Val Leu Gln Pro Gln Ala Lys Gly Phe Arg Ser Asp 
                85                  90                  95      


Xaa Gly Xaa Pro Glu Pro Leu Asp Pro Gln Gly Ser Leu Ser Leu Ser 
            100                 105                 110         


Gln Arg Xaa Ser Gln Leu Asp Pro Pro Ala Leu Gln Ala Pro Arg Pro 
        115                 120                 125             


Leu Pro Gln 
    130     


<210> 2922
<211> 297
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<400> 2922
Met Ser Glu Pro Pro Val Tyr Cys Asn Leu Val Asp Leu Arg Arg Cys 
1               5                   10                  15      


Pro Arg Ser Pro Pro Pro Gly Pro Ala Cys Pro Leu Leu Gln Arg Leu 
            20                  25                  30          


Asp Ala Trp Glu Gln His Leu Asp Pro Asn Ser Gly Arg Cys Phe Tyr 
        35                  40                  45              


Ile Asn Ser Leu Xaa Gly Cys Lys Ser Trp Lys Pro Pro Arg Arg Ser 
    50                  55                  60                  


Arg Ser Glu Xaa Asn Pro Gly Ser Met Glu Gly Xaa Gln Xaa Leu Lys 
65                  70                  75                  80  


Arg Asn Asn Asp Val Leu Gln Pro Gln Ala Lys Gly Phe Arg Ser Asp 
                85                  90                  95      


Xaa Gly Xaa Pro Glu Pro Leu Asp Pro Gln Gly Ser Leu Ser Leu Ser 
            100                 105                 110         


Gln Arg Xaa Ser Gln Leu Asp Pro Pro Ala Leu Gln Ala Pro Arg Pro 
        115                 120                 125             


Leu Pro Gln Leu Leu Asp Asp Pro His Glu Val Glu Lys Ser Gly Leu 
    130                 135                 140                 


Leu Asn Met Xaa Lys Ile Ala Gln Gly Gly Arg Lys Leu Arg Lys Asn 
145                 150                 155                 160 


Trp Gly Pro Ser Trp Val Val Leu Xaa Gly Asn Ser Leu Val Phe Tyr 
                165                 170                 175     


Arg Glu Pro Pro Pro Xaa Ala Pro Ser Ser Gly Trp Gly Pro Ala Gly 
            180                 185                 190         


Ser Arg Pro Glu Ser Ser Val Asp Leu Arg Gly Ala Ala Leu Ala His 
        195                 200                 205             


Gly Arg His Leu Ser Ser Arg Arg Asn Val Leu His Ile Arg Xaa Ile 
    210                 215                 220                 


Pro Gly His Glu Phe Leu Leu Gln Ser Asp His Glu Xaa Glu Leu Arg 
225                 230                 235                 240 


Ala Trp His Arg Ala Leu Arg Xaa Val Ile Glu Arg Leu Asp Arg Glu 
                245                 250                 255     


Asn Pro Leu Glu Leu Arg Leu Ser Gly Ser Gly Pro Ala Glu Leu Ser 
            260                 265                 270         


Ala Gly Glu Asp Glu Glu Glu Glu Ser Glu Leu Val Ser Lys Pro Leu 
        275                 280                 285             


Leu Arg Leu Ser Ser Arg Arg Ser Ser 
    290                 295         


<210> 2923
<211> 547
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<400> 2923
Met Ser Glu Pro Pro Val Tyr Cys Asn Leu Val Asp Leu Arg Arg Cys 
1               5                   10                  15      


Pro Arg Ser Pro Pro Pro Gly Pro Ala Cys Pro Leu Leu Gln Arg Leu 
            20                  25                  30          


Asp Ala Trp Glu Gln His Leu Asp Pro Asn Ser Gly Arg Cys Phe Tyr 
        35                  40                  45              


Ile Asn Ser Leu Xaa Gly Cys Lys Ser Trp Lys Pro Pro Arg Arg Ser 
    50                  55                  60                  


Arg Ser Glu Xaa Asn Pro Gly Ser Met Glu Gly Xaa Gln Xaa Leu Lys 
65                  70                  75                  80  


Arg Asn Asn Asp Val Leu Gln Pro Gln Ala Lys Gly Phe Arg Ser Asp 
                85                  90                  95      


Xaa Gly Xaa Pro Glu Pro Leu Asp Pro Gln Gly Ser Leu Ser Leu Ser 
            100                 105                 110         


Gln Arg Xaa Ser Gln Leu Asp Pro Pro Ala Leu Gln Ala Pro Arg Pro 
        115                 120                 125             


Leu Pro Gln Leu Leu Asp Asp Pro His Glu Val Glu Lys Ser Gly Leu 
    130                 135                 140                 


Leu Asn Met Xaa Lys Ile Ala Gln Gly Gly Arg Lys Leu Arg Lys Asn 
145                 150                 155                 160 


Trp Gly Pro Ser Trp Val Val Leu Xaa Gly Asn Ser Leu Val Phe Tyr 
                165                 170                 175     


Arg Glu Pro Pro Pro Xaa Ala Pro Ser Ser Gly Trp Gly Pro Ala Gly 
            180                 185                 190         


Ser Arg Pro Glu Ser Ser Val Asp Leu Arg Gly Ala Ala Leu Ala His 
        195                 200                 205             


Gly Arg His Leu Ser Ser Arg Arg Asn Val Leu His Ile Arg Xaa Ile 
    210                 215                 220                 


Pro Gly His Glu Phe Leu Leu Gln Ser Asp His Glu Xaa Glu Leu Arg 
225                 230                 235                 240 


Ala Trp His Arg Ala Leu Arg Xaa Val Ile Glu Arg Leu Asp Arg Glu 
                245                 250                 255     


Asn Pro Leu Glu Leu Arg Leu Ser Gly Ser Gly Pro Ala Glu Leu Ser 
            260                 265                 270         


Ala Gly Glu Asp Glu Glu Glu Glu Ser Glu Leu Val Ser Lys Pro Leu 
        275                 280                 285             


Leu Arg Leu Ser Ser Arg Arg Ser Ser Ile Arg Gly Pro Glu Gly Xaa 
    290                 295                 300                 


Glu Gln Asn Arg Val Arg Asn Lys Leu Lys Arg Leu Ile Ala Lys Arg 
305                 310                 315                 320 


Pro Pro Leu Gln Ser Leu Gln Glu Arg Gly Leu Leu Arg Asp Gln Val 
                325                 330                 335     


Phe Gly Cys Gln Leu Glu Ser Leu Cys Gln Arg Glu Gly Asp Xaa Val 
            340                 345                 350         


Pro Ser Phe Leu Arg Leu Cys Ile Ala Ala Val Asp Lys Arg Gly Leu 
        355                 360                 365             


Asp Val Asp Gly Ile Tyr Arg Val Ser Gly Asn Leu Ala Val Val Gln 
    370                 375                 380                 


Lys Leu Arg Phe Leu Val Asp Arg Glu Arg Ala Val Xaa Ser Asp Gly 
385                 390                 395                 400 


Arg Tyr Val Phe Pro Glu Gln Pro Gly Gln Glu Gly Arg Leu Asp Leu 
                405                 410                 415     


Asp Ser Xaa Glu Trp Asp Asp Ile His Val Val Xaa Gly Ala Leu Lys 
            420                 425                 430         


Leu Phe Leu Arg Glu Leu Pro Gln Pro Leu Val Pro Pro Leu Leu Leu 
        435                 440                 445             


Pro His Phe Arg Ala Ala Leu Ala Leu Ser Glu Ser Glu Gln Cys Leu 
    450                 455                 460                 


Ser Gln Ile Gln Glu Leu Ile Gly Ser Met Pro Lys Pro Asn His Asp 
465                 470                 475                 480 


Xaa Leu Arg Tyr Leu Leu Glu His Leu Cys Arg Val Ile Ala His Ser 
                485                 490                 495     


Asp Lys Asn Arg Met Xaa Pro His Asn Leu Gly Ile Val Phe Gly Pro 
            500                 505                 510         


Xaa Leu Phe Arg Pro Glu Gln Glu Xaa Ser Asp Pro Ala Ala His Ala 
        515                 520                 525             


Leu Tyr Pro Gly Gln Leu Val Gln Leu Met Leu Xaa Asn Phe Xaa Ser 
    530                 535                 540                 


Leu Phe Pro 
545         


<210> 2924
<211> 168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<400> 2924
Arg Asn Lys Leu Lys Arg Leu Ile Ala Lys Arg Pro Pro Leu Gln Ser 
1               5                   10                  15      


Leu Gln Glu Arg Gly Leu Leu Arg Asp Gln Val Phe Gly Cys Gln Leu 
            20                  25                  30          


Glu Ser Leu Cys Gln Arg Glu Gly Asp Xaa Val Pro Ser Phe Leu Arg 
        35                  40                  45              


Leu Cys Ile Ala Ala Val Asp Lys Arg Gly Leu Asp Val Asp Gly Ile 
    50                  55                  60                  


Tyr Arg Val Ser Gly Asn Leu Ala Val Val Gln Lys Leu Arg Phe Leu 
65                  70                  75                  80  


Val Asp Arg Glu Gly Arg Leu Asp Leu Asp Ser Xaa Glu Trp Asp Asp 
                85                  90                  95      


Ile His Val Val Xaa Gly Ala Leu Lys Leu Phe Leu Arg Glu Leu Pro 
            100                 105                 110         


Gln Pro Leu Val Pro Pro Leu Leu Leu Pro His Phe Arg Ala Ala Leu 
        115                 120                 125             


Ala Leu Ser Glu Ser Glu Gln Cys Leu Ser Gln Ile Gln Glu Leu Ile 
    130                 135                 140                 


Gly Ser Met Pro Lys Pro Asn His Asp Xaa Leu Arg Tyr Leu Leu Glu 
145                 150                 155                 160 


His Leu Cys Arg Val Ile Ala His 
                165             


<210> 2925
<211> 156
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<400> 2925
Xaa Glu Gly Asp Xaa Val Pro Ser Phe Leu Arg Leu Cys Ile Ala Ala 
1               5                   10                  15      


Val Asp Lys Arg Gly Leu Asp Val Asp Gly Ile Tyr Arg Val Ser Gly 
            20                  25                  30          


Asn Leu Ala Val Val Gln Lys Leu Arg Phe Leu Val Asp Arg Glu Arg 
        35                  40                  45              


Ala Val Xaa Ser Asp Gly Arg Tyr Val Phe Pro Glu Gln Pro Gly Gln 
    50                  55                  60                  


Ala Leu Ser Glu Ser Glu Gln Cys Leu Ser Gln Ile Gln Glu Leu Ile 
65                  70                  75                  80  


Gly Ser Met Pro Lys Pro Asn His Asp Xaa Leu Arg Tyr Leu Leu Glu 
                85                  90                  95      


His Leu Cys Arg Val Ile Ala His Ser Asp Lys Asn Arg Met Xaa Pro 
            100                 105                 110         


His Asn Leu Gly Ile Val Phe Gly Pro Xaa Leu Phe Arg Pro Glu Gln 
        115                 120                 125             


Glu Xaa Ser Asp Pro Ala Ala His Ala Leu Tyr Pro Gly Gln Leu Val 
    130                 135                 140                 


Gln Leu Met Leu Xaa Asn Phe Xaa Ser Leu Phe Pro 
145                 150                 155     


<210> 2926
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<400> 2926
Met Ala Glu Gln Glu Pro Xaa Ala Glu Gln Leu Ala Gln Ile Ala Ala 
1               5                   10                  15      


Glu Asn Glu Glu Asp Glu His Ser Val Asn Tyr Lys Pro Pro Ala Gln 
            20                  25                  30          


Lys Ser Ile Gln Glu Ile Gln Glu Leu Asp Lys Asp Asp Glu Ser Leu 
        35                  40                  45              


Arg Lys Tyr Lys Glu Ala Leu Leu Gly Arg Val Ala Val Ser Ala Asp 
    50                  55                  60                  


Pro Asn Val Pro Asn Val Val Val Xaa Gly Leu Xaa Leu Val Cys Ser 
65                  70                  75                  80  


Ser Ala Pro Gly Pro Leu Glu Leu Asp Leu Xaa Gly 
                85                  90          


<210> 2927
<211> 249
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<400> 2927
Met Ala Glu Gln Glu Pro Xaa Ala Glu Gln Leu Ala Gln Ile Ala Ala 
1               5                   10                  15      


Glu Asn Glu Glu Asp Glu His Ser Val Asn Tyr Lys Pro Pro Ala Gln 
            20                  25                  30          


Lys Ser Ile Gln Glu Ile Gln Glu Leu Asp Lys Asp Asp Glu Ser Leu 
        35                  40                  45              


Arg Lys Tyr Lys Glu Ala Leu Leu Gly Arg Val Ala Val Ser Ala Asp 
    50                  55                  60                  


Pro Asn Val Pro Asn Val Val Val Xaa Gly Leu Xaa Leu Val Cys Ser 
65                  70                  75                  80  


Ser Ala Pro Gly Pro Leu Glu Leu Asp Leu Xaa Gly Asp Leu Glu Ser 
                85                  90                  95      


Phe Lys Lys Gln Ser Phe Val Leu Lys Glu Gly Val Glu Tyr Arg Ile 
            100                 105                 110         


Lys Ile Ser Phe Arg Val Asn Arg Glu Ile Val Ser Gly Met Lys Tyr 
        115                 120                 125             


Ile Gln His Xaa Tyr Arg Lys Gly Val Lys Ile Asp Lys Xaa Asp Tyr 
    130                 135                 140                 


Met Xaa Xaa Xaa Arg Pro Xaa Xaa Cys Pro Gly Ser Gly Ile Ser Pro 
145                 150                 155                 160 


Ser Arg Arg Xaa Gly Arg Xaa Glu Pro Ser Gln Arg Arg Ala Gly Gln 
                165                 170                 175     


Xaa Asp Gly Arg Xaa Xaa Asp Arg Arg Met Cys Pro Pro Gln Pro Leu 
            180                 185                 190         


Pro Ser Pro Tyr Gln Ser Ala Asp Arg Pro Ser Val Pro Leu Pro Pro 
        195                 200                 205             


Trp Ser Ala Ser Leu Ala Trp Leu Asn Arg Val Pro Pro Xaa Pro Leu 
    210                 215                 220                 


Leu Ser Pro Pro Pro Pro Xaa Gly Pro Ala Ser Ser Val Ser Cys Leu 
225                 230                 235                 240 


Val Ala Ala Ser Ala Cys Ala Val Gly 
                245                 


<210> 2928
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<400> 2928
Met Ala Glu Gln Glu Pro Xaa Ala Glu Gln Leu Ala Gln Ile Ala Ala 
1               5                   10                  15      


Glu Asn Glu Glu Asp Glu His Ser Val Asn Tyr Lys Pro Pro Ala Gln 
            20                  25                  30          


Lys Ser Ile Gln Glu Ile Gln Glu Leu Asp Lys Asp Asp Glu Ser Leu 
        35                  40                  45              


Arg Lys Tyr Lys Glu Ala Leu Leu Gly Arg Val Ala Val Ser Ala Asp 
    50                  55                  60                  


Pro Asn Val Pro Asn Val Val Val Xaa Gly Leu Xaa Leu Val Cys Ser 
65                  70                  75                  80  


Ser Ala Pro Gly Pro Leu Glu Leu Asp Leu Xaa Gly Asp Leu Glu Ser 
                85                  90                  95      


Phe Lys Lys Gln Ser Phe Val Leu Lys Glu Gly Val Glu Tyr Arg Ile 
            100                 105                 110         


Lys Ile Ser Phe Arg Val Asn Arg Glu Ile Val Ser Gly Met Lys Tyr 
        115                 120                 125             


Ile Gln His Xaa Tyr Arg Lys Gly Val Lys Ile Asp Lys Xaa Asp Tyr 
    130                 135                 140                 


Met Val Gly Ser Tyr Gly Pro Arg Ala Glu Glu Tyr Glu Phe Leu Xaa 
145                 150                 155                 160 


Pro Val Glu Glu Ala Pro Lys Gly Met Leu Ala Arg Gly Ser Tyr Ser 
                165                 170                 175     


Ile Lys Ser Arg Phe Xaa Asp Asp Asp Lys Xaa Asp His Leu Ser Trp 
            180                 185                 190         


Glu Trp Asn Leu Xaa Ile Lys Lys Asp Trp Lys Asp 
        195                 200                 


<210> 2929
<211> 194
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<400> 2929
Met Ala Glu Gln Glu Pro Xaa Ala Glu Gln Leu Ala Gln Ile Ala Ala 
1               5                   10                  15      


Glu Asn Glu Glu Asp Glu His Ser Val Asn Tyr Lys Pro Pro Ala Gln 
            20                  25                  30          


Lys Ser Ile Gln Glu Ile Gln Glu Leu Asp Lys Asp Asp Glu Ser Leu 
        35                  40                  45              


Arg Lys Tyr Lys Glu Ala Leu Leu Gly Arg Val Ala Val Ser Ala Asp 
    50                  55                  60                  


Pro Asn Val Pro Asn Val Val Val Xaa Gly Leu Xaa Leu Val Cys Ser 
65                  70                  75                  80  


Ser Ala Pro Gly Pro Leu Glu Leu Asp Leu Xaa Gly Asp Leu Glu Ser 
                85                  90                  95      


Phe Lys Lys Gln Ser Phe Val Leu Lys Glu Gly Val Glu Tyr Arg Ile 
            100                 105                 110         


Lys Ile Ser Phe Arg Val Asn Arg Glu Ile Val Ser Gly Met Lys Tyr 
        115                 120                 125             


Ile Gln His Xaa Tyr Arg Lys Gly Val Lys Ile Asp Lys Xaa Asp Tyr 
    130                 135                 140                 


Met Val Gly Ser Tyr Gly Pro Arg Ala Glu Glu Tyr Glu Phe Leu Xaa 
145                 150                 155                 160 


Pro Val Glu Glu Ala Pro Lys Gly Ser Ile Ser Pro Ser His Pro Arg 
                165                 170                 175     


Pro Gly Phe Arg Arg Glu Arg Ser Ser His Ser Pro Gly Pro Val Val 
            180                 185                 190         


Ala Pro 
        


<210> 2930
<211> 235
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<400> 2930
Met Ala Glu Gln Glu Pro Xaa Ala Glu Gln Leu Ala Gln Ile Ala Ala 
1               5                   10                  15      


Glu Asn Glu Glu Asp Glu His Ser Val Asn Tyr Lys Pro Pro Ala Gln 
            20                  25                  30          


Lys Ser Ile Gln Glu Ile Gln Glu Leu Asp Lys Asp Asp Glu Ser Leu 
        35                  40                  45              


Arg Lys Tyr Lys Glu Ala Leu Leu Gly Arg Val Ala Val Ser Ala Asp 
    50                  55                  60                  


Pro Asn Val Pro Asn Val Val Val Xaa Gly Leu Xaa Leu Val Cys Ser 
65                  70                  75                  80  


Ser Ala Pro Gly Pro Leu Glu Leu Asp Leu Xaa Gly Asp Leu Glu Ser 
                85                  90                  95      


Phe Lys Lys Gln Ser Phe Val Leu Lys Glu Gly Val Glu Tyr Arg Ile 
            100                 105                 110         


Lys Ile Ser Phe Arg Val Asn Arg Glu Ile Val Ser Gly Met Lys Tyr 
        115                 120                 125             


Ile Gln His Xaa Tyr Arg Lys Gly Val Lys Ile Asp Lys Xaa Asp Tyr 
    130                 135                 140                 


Met Val Gly Ser Tyr Gly Pro Arg Ala Glu Glu Tyr Glu Phe Leu Xaa 
145                 150                 155                 160 


Pro Val Glu Glu Ala Pro Lys Gly Ser Ile Ser Pro Ser His Pro Arg 
                165                 170                 175     


Pro Gly Phe Arg Arg Glu Arg Ser Ser His Ser Pro Gly Pro Val Val 
            180                 185                 190         


Ala Pro Gly Arg Val Arg Leu Leu Leu Arg Gly Gly Ala Gly Val Trp 
        195                 200                 205             


Asp Ala Arg Pro Arg Gly Gly Arg Ala Val Leu Gln Pro Arg Cys Ser 
    210                 215                 220                 


Leu Ala Ser Pro Leu Val Ala Val Gly Pro Val 
225                 230                 235 


<210> 2931
<211> 160
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<400> 2931
Met Ala Glu Gln Glu Pro Xaa Ala Glu Gln Leu Ala Gln Ile Ala Ala 
1               5                   10                  15      


Glu Asn Glu Glu Asp Glu His Ser Val Asn Tyr Lys Pro Pro Ala Gln 
            20                  25                  30          


Lys Ser Ile Gln Glu Ile Gln Glu Leu Asp Lys Asp Asp Glu Ser Leu 
        35                  40                  45              


Arg Lys Tyr Lys Glu Ala Leu Leu Gly Arg Val Ala Val Ser Ala Asp 
    50                  55                  60                  


Pro Asn Val Pro Asn Val Val Val Xaa Gly Leu Xaa Leu Val Cys Ser 
65                  70                  75                  80  


Ser Ala Pro Gly Pro Leu Glu Leu Asp Leu Xaa Gly Asp Leu Glu Ser 
                85                  90                  95      


Phe Lys Lys Gln Ser Phe Val Leu Lys Glu Gly Val Glu Tyr Arg Ile 
            100                 105                 110         


Lys Ile Ser Phe Arg Val Asn Arg Glu Ile Val Ser Gly Met Lys Tyr 
        115                 120                 125             


Ile Gln His Xaa Tyr Arg Lys Gly Val Lys Asn Asp Asp Lys Xaa Asp 
    130                 135                 140                 


His Leu Ser Trp Glu Trp Asn Leu Xaa Ile Lys Lys Asp Trp Lys Asp 
145                 150                 155                 160 


<210> 2932
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<400> 2932
Met Ala Glu Gln Glu Pro Xaa Ala Glu Gln Leu Ala Gln Ile Ala Ala 
1               5                   10                  15      


Glu Asn Glu Glu Asp Glu His Ser Val Asn Tyr Lys Pro Pro Ala Gln 
            20                  25                  30          


Lys Ser Ile Gln Glu Ile Gln Glu Leu Asp Lys Asp Asp Glu Ser Leu 
        35                  40                  45              


Arg Lys Tyr Lys Glu Ala Leu Leu Gly Arg Val Ala Val Ser Ala Val 
    50                  55                  60                  


Asp Lys Xaa Asp Tyr Met Val Gly Ser Tyr Gly Pro Arg Ala Glu Glu 
65                  70                  75                  80  


Tyr Glu Phe Leu Xaa Pro Val Glu Glu Ala Pro Lys Gly Met Leu Ala 
                85                  90                  95      


Arg Gly Ser Tyr Ser Ile Lys Ser Arg Phe Xaa Asp Asp Asp Lys Xaa 
            100                 105                 110         


Asp His Leu Ser Trp Glu Trp Asn Leu Xaa Ile Lys Lys Asp Trp Lys 
        115                 120                 125             


Asp 
    


<210> 2933
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 2933
Met Xaa Glu Lys Ala Pro Glu Pro His Val Glu Glu Asp Asp Asp Asp 
1               5                   10                  15      


Glu Leu Asp Ser Lys Leu Asn Tyr Lys Pro Pro Pro Gln Lys Ser Leu 
            20                  25                  30          


Lys Glu Leu Gln Glu Met Asp Lys Asp Asp Glu Ser Leu Ile Lys Tyr 
        35                  40                  45              


Lys Lys Xaa Leu Leu Gly Asp Gly Pro Val Val Xaa Asp Pro Lys Ala 
    50                  55                  60                  


Pro Asn Val Val Val Xaa Arg Leu Xaa Leu Val Cys Glu Ser Ala Pro 
65                  70                  75                  80  


Gly Pro Ile Xaa Met Asp Leu Xaa 
                85              


<210> 2934
<211> 112
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 2934
Met Xaa Glu Lys Ala Pro Glu Pro His Val Glu Glu Asp Asp Asp Asp 
1               5                   10                  15      


Glu Leu Asp Ser Lys Leu Asn Tyr Lys Pro Pro Pro Gln Lys Ser Leu 
            20                  25                  30          


Lys Glu Leu Gln Glu Met Asp Lys Asp Asp Glu Ser Leu Ile Lys Tyr 
        35                  40                  45              


Lys Lys Xaa Leu Leu Gly Asp Gly Pro Val Val Xaa Asp Pro Lys Ala 
    50                  55                  60                  


Pro Asn Val Val Val Xaa Arg Leu Xaa Leu Val Cys Glu Ser Ala Pro 
65                  70                  75                  80  


Gly Pro Ile Xaa Met Asp Leu Xaa Gly Asp Leu Glu Ala Leu Lys Lys 
                85                  90                  95      


Glu Xaa Ile Val Leu Lys Glu Gly Ser Glu Tyr Arg Val Lys Ile His 
            100                 105                 110         


<210> 2935
<211> 159
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<400> 2935
Met Xaa Glu Lys Ala Pro Glu Pro His Val Glu Glu Asp Asp Asp Asp 
1               5                   10                  15      


Glu Leu Asp Ser Lys Leu Asn Tyr Lys Pro Pro Pro Gln Lys Ser Leu 
            20                  25                  30          


Lys Glu Leu Gln Glu Met Asp Lys Asp Asp Glu Ser Leu Ile Lys Tyr 
        35                  40                  45              


Lys Lys Xaa Leu Leu Gly Asp Gly Pro Val Val Xaa Asp Pro Lys Ala 
    50                  55                  60                  


Pro Asn Val Val Val Xaa Arg Leu Xaa Leu Val Cys Glu Ser Ala Pro 
65                  70                  75                  80  


Gly Pro Ile Xaa Met Asp Leu Xaa Gly Asp Leu Glu Ala Leu Lys Lys 
                85                  90                  95      


Glu Xaa Ile Val Leu Lys Glu Gly Ser Glu Tyr Arg Val Lys Ile His 
            100                 105                 110         


Phe Lys Val Asn Arg Asp Ile Val Ser Gly Leu Lys Tyr Val Gln His 
        115                 120                 125             


Xaa Tyr Arg Xaa Gly Val Lys Val Asp Lys Ala Xaa Phe Met Val Gly 
    130                 135                 140                 


Ser Tyr Gly Pro Arg Pro Glu Glu Tyr Glu Phe Leu Xaa Pro Val 
145                 150                 155                 


<210> 2936
<211> 201
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<400> 2936
Met Xaa Glu Lys Ala Pro Glu Pro His Val Glu Glu Asp Asp Asp Asp 
1               5                   10                  15      


Glu Leu Asp Ser Lys Leu Asn Tyr Lys Pro Pro Pro Gln Lys Ser Leu 
            20                  25                  30          


Lys Glu Leu Gln Glu Met Asp Lys Asp Asp Glu Ser Leu Ile Lys Tyr 
        35                  40                  45              


Lys Lys Xaa Leu Leu Gly Asp Gly Pro Val Val Xaa Asp Pro Lys Ala 
    50                  55                  60                  


Pro Asn Val Val Val Xaa Arg Leu Xaa Leu Val Cys Glu Ser Ala Pro 
65                  70                  75                  80  


Gly Pro Ile Xaa Met Asp Leu Xaa Gly Asp Leu Glu Ala Leu Lys Lys 
                85                  90                  95      


Glu Xaa Ile Val Leu Lys Glu Gly Ser Glu Tyr Arg Val Lys Ile His 
            100                 105                 110         


Phe Lys Val Asn Arg Asp Ile Val Ser Gly Leu Lys Tyr Val Gln His 
        115                 120                 125             


Xaa Tyr Arg Xaa Gly Val Lys Val Asp Lys Ala Xaa Phe Met Val Gly 
    130                 135                 140                 


Ser Tyr Gly Pro Arg Pro Glu Glu Tyr Glu Phe Leu Xaa Pro Val Glu 
145                 150                 155                 160 


Glu Ala Pro Lys Gly Met Leu Ala Arg Gly Xaa Tyr His Asn Lys Ser 
                165                 170                 175     


Phe Phe Xaa Asp Asp Asp Lys Gln Asp His Leu Ser Trp Glu Trp Asn 
            180                 185                 190         


Leu Ser Ile Lys Lys Glu Trp Xaa Glu 
        195                 200     


<210> 2937
<211> 195
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<400> 2937
Xaa Glu Pro His Val Glu Glu Asp Asp Asp Asp Glu Leu Asp Ser Lys 
1               5                   10                  15      


Leu Asn Tyr Lys Pro Pro Pro Gln Lys Ser Leu Lys Glu Leu Gln Glu 
            20                  25                  30          


Met Asp Lys Asp Asp Glu Ser Leu Ile Lys Tyr Lys Lys Xaa Leu Leu 
        35                  40                  45              


Gly Asp Gly Pro Val Val Xaa Asp Pro Lys Ala Pro Asn Val Val Val 
    50                  55                  60                  


Xaa Arg Leu Xaa Leu Val Cys Glu Ser Ala Pro Gly Pro Ile Xaa Met 
65                  70                  75                  80  


Asp Leu Xaa Asp Leu Glu Ala Leu Lys Lys Glu Xaa Ile Val Leu Lys 
                85                  90                  95      


Glu Gly Ser Glu Tyr Arg Val Lys Ile His Phe Lys Val Asn Arg Asp 
            100                 105                 110         


Ile Val Ser Gly Leu Lys Tyr Val Gln His Xaa Tyr Arg Xaa Gly Val 
        115                 120                 125             


Lys Val Asp Lys Ala Xaa Phe Met Val Gly Ser Tyr Gly Pro Arg Pro 
    130                 135                 140                 


Glu Glu Tyr Glu Phe Leu Xaa Pro Val Glu Glu Ala Pro Lys Gly Met 
145                 150                 155                 160 


Leu Ala Arg Gly Xaa Tyr His Asn Lys Ser Phe Phe Xaa Asp Asp Asp 
                165                 170                 175     


Lys Gln Asp His Leu Ser Trp Glu Trp Asn Leu Ser Ile Lys Lys Glu 
            180                 185                 190         


Trp Xaa Glu 
        195 


<210> 2938
<211> 116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<400> 2938
Met Asp Leu Xaa Gly Asp Leu Ala Val Leu Lys Asp Gln Val Phe Val 
1               5                   10                  15      


Leu Lys Glu Gly Val Asp Tyr Arg Val Lys Ile Ser Phe Lys Val His 
            20                  25                  30          


Arg Glu Ile Val Ser Gly Leu Lys Cys Leu His His Xaa Tyr Arg Arg 
        35                  40                  45              


Gly Leu Arg Val Asp Lys Xaa Val Tyr Met Val Gly Ser Tyr Gly Pro 
    50                  55                  60                  


Ser Ala Gln Glu Tyr Glu Phe Val Xaa Pro Val Glu Glu Ala Pro Arg 
65                  70                  75                  80  


Gly Ala Leu Val Arg Gly Pro Tyr Leu Val Val Ser Leu Phe Xaa Asp 
                85                  90                  95      


Asp Asp Arg Xaa His His Leu Ser Trp Glu Trp Gly Leu Cys Ile Cys 
            100                 105                 110         


Gln Asp Trp Lys 
        115     


<210> 2939
<211> 178
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<400> 2939
Met Leu Gly Leu Asp Ala Cys Glu Leu Gly Ala Gln Leu Leu Glu Leu 
1               5                   10                  15      


Leu Arg Leu Ala Leu Cys Ala Arg Val Leu Leu Ala Asp Lys Glu Gly 
            20                  25                  30          


Gly Pro Pro Ala Val Asp Glu Val Leu Asp Glu Ala Val Pro Glu Tyr 
        35                  40                  45              


Arg Ala Pro Gly Arg Lys Ser Leu Leu Glu Ile Arg Gln Leu Asp Pro 
    50                  55                  60                  


Asp Asp Arg Ser Leu Ala Lys Tyr Lys Arg Val Leu Leu Gly Pro Leu 
65                  70                  75                  80  


Pro Pro Ala Val Asp Pro Ser Leu Pro Asn Val Gln Val Xaa Arg Leu 
                85                  90                  95      


Xaa Leu Leu Ser Glu Gln Ala Pro Gly Pro Val Val Met Asp Leu Xaa 
            100                 105                 110         


Gly Asp Leu Ala Val Leu Lys Asp Gln Val Phe Val Leu Lys Glu Gly 
        115                 120                 125             


Val Asp Tyr Arg Val His Arg Glu Ile Val Ser Gly Leu Lys Cys Leu 
    130                 135                 140                 


His His Xaa Tyr Arg Arg Gly Leu Arg Val Asp Lys Xaa Val Tyr Met 
145                 150                 155                 160 


Val Gly Ser Tyr Gly Pro Ser Ala Gln Glu Tyr Glu Phe Val Xaa Pro 
                165                 170                 175     


Val Glu 
        


<210> 2940
<211> 225
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<400> 2940
Met Leu Gly Leu Asp Ala Cys Glu Leu Gly Ala Gln Leu Leu Glu Leu 
1               5                   10                  15      


Leu Arg Leu Ala Leu Cys Ala Arg Val Leu Leu Ala Asp Lys Glu Gly 
            20                  25                  30          


Gly Pro Pro Ala Val Asp Glu Val Leu Asp Glu Ala Val Pro Glu Tyr 
        35                  40                  45              


Arg Ala Pro Gly Arg Lys Ser Leu Leu Glu Ile Arg Gln Leu Asp Pro 
    50                  55                  60                  


Asp Asp Arg Ser Leu Ala Lys Tyr Lys Arg Val Leu Leu Gly Pro Leu 
65                  70                  75                  80  


Pro Pro Ala Val Asp Pro Ser Leu Pro Asn Val Gln Val Xaa Arg Leu 
                85                  90                  95      


Xaa Leu Leu Ser Glu Gln Ala Pro Gly Pro Val Val Met Asp Leu Xaa 
            100                 105                 110         


Gly Asp Leu Ala Val Leu Lys Asp Gln Val Phe Val Leu Lys Glu Gly 
        115                 120                 125             


Val Asp Tyr Arg Val Lys Ile Ser Phe Lys Val His Arg Glu Ile Val 
    130                 135                 140                 


Ser Gly Leu Lys Cys Leu His His Xaa Tyr Arg Arg Gly Leu Arg Val 
145                 150                 155                 160 


Asp Lys Xaa Val Tyr Met Val Gly Ser Tyr Gly Pro Ser Ala Gln Glu 
                165                 170                 175     


Tyr Glu Phe Val Xaa Pro Val Glu Glu Ala Pro Arg Gly Ala Leu Val 
            180                 185                 190         


Arg Gly Pro Tyr Leu Val Val Ser Leu Phe Xaa Asp Asp Asp Arg Xaa 
        195                 200                 205             


His His Leu Ser Trp Glu Trp Gly Leu Cys Ile Cys Gln Asp Trp Lys 
    210                 215                 220                 


Asp 
225 


<210> 2941
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<400> 2941
Met Ser Ala Ser Cys Asp Gly Cys Val Gly Ser Arg Pro Pro Val His 
1               5                   10                  15      


Leu Ala Ser Gly Tyr Ser Leu Ala Asp Leu Leu Val Leu Glu Met Gly 
            20                  25                  30          


Met Gly Xaa Gln Cys Trp Xaa Glu Asp Gln Arg Arg Trp Ser Ser Leu 
        35                  40                  45              


Trp Pro Trp Ser His Leu Ser Ser Asp Pro Ser Leu Pro Asn Val Gln 
    50                  55                  60                  


Val Xaa Arg Leu Xaa Leu Leu Ser Glu Gln Ala Pro 
65                  70                  75      


<210> 2942
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 2942
Met Ser Ala Ser Cys Asp Gly Cys Val Gly Ser Arg Pro Pro Val His 
1               5                   10                  15      


Leu Ala Ser Gly Tyr Ser Leu Ala Asp Leu Leu Val Leu Glu Met Gly 
            20                  25                  30          


Met Gly Xaa Gln Cys Trp Xaa Glu Asp Gln Arg Arg Trp Ser Ser Leu 
        35                  40                  45              


Trp Pro Trp Ser His Leu Ser Ser Val Leu Leu Ala Asp Lys Glu Gly 
    50                  55                  60                  


Gly Pro Pro Ala Val Asp Glu Val Leu Asp Glu Ala Val Pro Glu Tyr 
65                  70                  75                  80  


Arg Ala Pro Gly Arg Lys Ser Leu Leu Glu Ile Arg Gln Leu Asp Pro 
                85                  90                  95      


Asp Asp Arg Ser Leu Ala Lys Tyr Lys Arg Val Leu Leu Gly Pro Leu 
            100                 105                 110         


Pro Pro Ala Val Asp Pro Ser Leu Pro Asn Val Gln Val Xaa Arg Leu 
        115                 120                 125             


Xaa Leu Leu Ser Glu Gln Ala Pro 
    130                 135     


<210> 2943
<211> 275
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<400> 2943
Phe Phe Arg Lys Lys Val Met Gly Asn Arg Arg Ser Asp Glu Pro Ala 
1               5                   10                  15      


Lys Xaa Lys Lys Gly Leu Ser Ser Ile Leu Asp Ala Ala Arg Trp Asn 
            20                  25                  30          


Arg Gly Glu Pro Gln Ala Glu Lys Pro Gly Ala Xaa Asp Arg Lys Gly 
        35                  40                  45              


Gly Val Gly Met Pro Ser Arg Asp Arg Asn Ile Gly Ala Pro Gly Gln 
    50                  55                  60                  


Asp Xaa Pro Gly Val Ser Leu His Pro Leu Ser Leu Asp Ser Pro Asp 
65                  70                  75                  80  


Arg Glu Pro Gly Ala Asp Ala Pro Leu Glu Leu Gly Asp Ser Ser Pro 
                85                  90                  95      


Gln Gly Pro Met Ser Leu Glu Ser Leu Ala Pro Pro Glu Ser Xaa Asp 
            100                 105                 110         


Glu Gly Ala Glu Xaa Glu Arg Arg Trp Lys Arg Leu Ser Gly Arg Leu 
        115                 120                 125             


Gly Arg Ser Glu Ser Leu Arg Val Ser Asp Arg Arg Arg Pro Ser Arg 
    130                 135                 140                 


Gly Ser Leu Gly Ala Lys Gly Arg Gly Gly Gly Arg Ser Arg Ser Asp 
145                 150                 155                 160 


Val Asp Met Asp Pro Ser Ser Ala Xaa Ala Val Leu Gly Pro Ala Arg 
                165                 170                 175     


Arg Ala Xaa Pro Glu Pro Gly Asp Glu Gly Glu Pro Gly Arg Ser Gly 
            180                 185                 190         


Leu Glu Leu Glu Pro Glu Glu Pro Pro Gly Trp Arg Glu Leu Val Pro 
        195                 200                 205             


Pro Asp Xaa Leu His Ser Leu Pro Lys Ser Gln Val Lys Arg Gln Glu 
    210                 215                 220                 


Val Ile Ser Glu Leu Leu Val Xaa Glu Ala Ala His Val Arg Met Leu 
225                 230                 235                 240 


Arg Val Leu His Asp Leu Phe Phe Gln Pro Met Ala Glu Cys Leu Phe 
                245                 250                 255     


Phe Pro Leu Glu Glu Leu Gln Asn Ile Phe Pro Ser Leu Asp Glu Leu 
            260                 265                 270         


Ile Glu Val 
        275 


<210> 2944
<211> 927
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<400> 2944
Met Ala Ser Leu Ser Xaa Trp Ser Ser Pro Ala Glu Pro Arg Glu Met 
1               5                   10                  15      


Glu Asp Phe Ala Arg Gly Ala Ala Ser Pro Gly Pro Ser Arg Pro Gly 
            20                  25                  30          


Leu Val Pro Val Ser Ile Ile Gly Ala Glu Asp Glu Asp Phe Glu Asn 
        35                  40                  45              


Glu Leu Glu Xaa Asn Ser Glu Glu Gln Asn Ser Gln Phe Gln Ser Leu 
    50                  55                  60                  


Glu Gln Val Lys Arg Arg Pro Ala His Leu Met Ala Leu Leu Gln His 
65                  70                  75                  80  


Val Ala Leu Gln Phe Glu Pro Gly Pro Leu Leu Cys Cys Leu His Ala 
                85                  90                  95      


Asp Met Leu Gly Ser Leu Gly Pro Lys Glu Ala Lys Lys Ala Phe Leu 
            100                 105                 110         


Asp Phe Tyr His Ser Phe Leu Glu Lys Xaa Ala Val Leu Arg Val Pro 
        115                 120                 125             


Val Pro Pro Asn Val Ala Phe Glu Leu Asp Arg Xaa Arg Ala Asp Leu 
    130                 135                 140                 


Ile Ser Glu Asp Val Gln Arg Arg Phe Val Gln Glu Val Val Gln Ser 
145                 150                 155                 160 


Gln Gln Val Ala Val Gly Arg Gln Leu Glu Asp Phe Arg Ser Lys Arg 
                165                 170                 175     


Leu Met Gly Met Xaa Pro Trp Glu Gln Glu Leu Ala Gln Leu Glu Ala 
            180                 185                 190         


Trp Val Gly Arg Asp Arg Ala Ser Tyr Glu Ala Arg Glu Arg His Val 
        195                 200                 205             


Ala Glu Arg Leu Leu Met His Leu Glu Glu Met Gln His Xaa Ile Ser 
    210                 215                 220                 


Xaa Asp Glu Glu Lys Ser Ala Ala Val Val Asn Ala Ile Gly Leu Tyr 
225                 230                 235                 240 


Met Arg His Leu Gly Val Arg Xaa Lys Ser Gly Asp Lys Lys Ser Gly 
                245                 250                 255     


Arg Asn Phe Phe Arg Lys Lys Val Met Gly Asn Arg Arg Ser Asp Glu 
            260                 265                 270         


Pro Ala Lys Xaa Lys Lys Gly Leu Ser Ser Ile Leu Asp Ala Ala Arg 
        275                 280                 285             


Trp Asn Arg Gly Glu Pro Gln Val Pro Asp Phe Arg His Leu Lys Ala 
    290                 295                 300                 


Glu Val Asp Ala Glu Lys Pro Gly Ala Xaa Asp Arg Lys Gly Gly Val 
305                 310                 315                 320 


Gly Met Pro Ser Arg Asp Arg Asn Ile Gly Ala Pro Gly Gln Asp Xaa 
                325                 330                 335     


Pro Gly Val Ser Leu His Pro Leu Ser Leu Asp Ser Pro Asp Arg Glu 
            340                 345                 350         


Pro Gly Ala Asp Ala Pro Leu Glu Leu Gly Asp Ser Ser Pro Gln Gly 
        355                 360                 365             


Pro Met Ser Leu Glu Ser Leu Ala Pro Pro Glu Ser Xaa Asp Glu Gly 
    370                 375                 380                 


Ala Glu Xaa Glu Ser Pro Glu Pro Gly Asp Glu Gly Glu Pro Gly Arg 
385                 390                 395                 400 


Ser Gly Leu Glu Leu Glu Pro Glu Glu Pro Pro Gly Trp Arg Glu Leu 
                405                 410                 415     


Val Pro Pro Asp Xaa Leu His Ser Leu Pro Lys Ser Gln Val Lys Arg 
            420                 425                 430         


Gln Glu Val Ile Ser Glu Leu Leu Val Xaa Glu Ala Ala His Val Arg 
        435                 440                 445             


Met Leu Arg Val Leu His Asp Leu Phe Phe Gln Pro Met Ala Glu Cys 
    450                 455                 460                 


Leu Phe Phe Pro Leu Glu Glu Leu Gln Asn Ile Phe Pro Ser Leu Asp 
465                 470                 475                 480 


Glu Leu Ile Glu Val His Ser Leu Phe Leu Asp Arg Leu Met Lys Arg 
                485                 490                 495     


Arg Gln Glu Ser Gly Tyr Leu Ile Glu Glu Ile Gly Asp Val Leu Leu 
            500                 505                 510         


Ala Arg Phe Asp Gly Ala Glu Gly Ser Trp Phe Gln Lys Ile Ser Ser 
        515                 520                 525             


Arg Phe Cys Ser Arg Gln Ser Phe Ala Leu Glu Gln Leu Lys Ala Lys 
    530                 535                 540                 


Gln Arg Lys Asp Pro Arg Phe Cys Ala Phe Val Gln Glu Ala Glu Ser 
545                 550                 555                 560 


Arg Pro Arg Cys Arg Arg Leu Gln Leu Lys Asp Met Ile Pro Xaa Glu 
                565                 570                 575     


Met Gln Arg Leu Xaa Lys Tyr Pro Leu Leu Leu Gln Ser Ile Gly Gln 
            580                 585                 590         


Asn Xaa Glu Glu Pro Xaa Glu Arg Glu Lys Val Glu Leu Ala Ala Glu 
        595                 600                 605             


Cys Cys Arg Glu Ile Leu His His Val Asn Gln Ala Val Arg Asp Met 
    610                 615                 620                 


Glu Asp Leu Leu Arg Leu Lys Asp Tyr Gln Arg Arg Leu Asp Leu Ser 
625                 630                 635                 640 


His Leu Arg Gln Ser Ser Asp Pro Met Leu Ser Glu Phe Lys Asn Leu 
                645                 650                 655     


Asp Ile Xaa Lys Lys Lys Leu Val His Glu Gly Pro Leu Xaa Trp Arg 
            660                 665                 670         


Val Xaa Lys Asp Lys Ala Val Glu Val His Val Leu Leu Leu Asp Asp 
        675                 680                 685             


Leu Leu Leu Leu Leu Gln Arg Gln Asp Glu Arg Leu Leu Leu Lys Ser 
    690                 695                 700                 


His Ser Arg Xaa Leu Xaa Pro Xaa Pro Asp Gly Lys Xaa Met Leu Arg 
705                 710                 715                 720 


Pro Val Leu Arg Leu Xaa Ser Ala Met Xaa Arg Glu Val Ala Xaa Asp 
                725                 730                 735     


His Lys Ala Phe Tyr Val Leu Phe Xaa Trp Asp Gln Glu Ala Gln Ile 
            740                 745                 750         


Tyr Glu Leu Val Ala Gln Xaa Val Ser Glu Arg Lys Asn Trp Cys Ala 
        755                 760                 765             


Leu Ile Xaa Glu Xaa Ala Gly Ser Leu Lys Val Pro Ala Pro Ala Ser 
    770                 775                 780                 


Arg Pro Lys Pro Arg Pro Ser Pro Ser Ser Xaa Arg Glu Pro Leu Leu 
785                 790                 795                 800 


Ser Ser Ser Glu Asn Gly Asn Gly Gly Arg Glu Xaa Ser Pro Ala Asp 
                805                 810                 815     


Ala Arg Xaa Glu Arg Ile Leu Ser Asp Leu Leu Pro Phe Cys Arg Pro 
            820                 825                 830         


Gly Pro Glu Gly Gln Leu Ala Ala Xaa Ala Leu Arg Lys Val Leu Ser 
        835                 840                 845             


Leu Lys Gln Leu Leu Phe Pro Ala Glu Glu Asp Asn Gly Ala Gly Pro 
    850                 855                 860                 


Pro Arg Asp Gly Asp Gly Val Pro Gly Gly Gly Pro Leu Ser Pro Ala 
865                 870                 875                 880 


Arg Xaa Gln Glu Ile Gln Glu Asn Leu Leu Ser Leu Glu Glu Xaa Met 
                885                 890                 895     


Lys Gln Leu Glu Glu Leu Glu Glu Glu Phe Cys Arg Leu Arg Pro Leu 
            900                 905                 910         


Leu Ser Gln Leu Gly Gly Asn Ser Val Pro Gln Pro Gly Cys Xaa 
        915                 920                 925         


<210> 2945
<211> 948
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<400> 2945
Met Ala Ser Leu Ser Xaa Trp Ser Ser Pro Ala Glu Pro Arg Glu Met 
1               5                   10                  15      


Glu Asp Phe Ala Arg Gly Ala Ala Ser Pro Gly Pro Ser Arg Pro Gly 
            20                  25                  30          


Leu Val Pro Val Ser Ile Ile Gly Ala Glu Asp Glu Asp Phe Glu Asn 
        35                  40                  45              


Glu Leu Glu Xaa Asn Ser Glu Glu Gln Asn Ser Gln Phe Gln Ser Leu 
    50                  55                  60                  


Glu Gln Val Lys Arg Arg Pro Ala His Leu Met Ala Leu Leu Gln His 
65                  70                  75                  80  


Val Ala Leu Gln Phe Glu Pro Gly Pro Leu Val Leu Arg Val Pro Val 
                85                  90                  95      


Pro Pro Asn Val Ala Phe Glu Leu Asp Arg Xaa Arg Ala Asp Leu Ile 
            100                 105                 110         


Ser Glu Asp Val Gln Arg Arg Phe Val Gln Glu Val Val Gln Ser Gln 
        115                 120                 125             


Gln Val Ala Val Gly Arg Gln Leu Glu Asp Phe Arg Ser Lys Arg Leu 
    130                 135                 140                 


Met Gly Met Xaa Pro Trp Glu Gln Glu Leu Ala Gln Leu Glu Ala Trp 
145                 150                 155                 160 


Val Gly Arg Asp Arg Ala Ser Tyr Glu Ala Arg Glu Arg His Val Ala 
                165                 170                 175     


Glu Arg Leu Leu Met His Leu Glu Glu Met Gln His Xaa Ile Ser Xaa 
            180                 185                 190         


Asp Glu Glu Lys Ser Ala Ala Val Val Asn Ala Ile Gly Leu Tyr Met 
        195                 200                 205             


Arg His Leu Gly Val Arg Xaa Lys Ser Gly Asp Lys Lys Ser Gly Arg 
    210                 215                 220                 


Asn Phe Phe Arg Lys Lys Val Met Gly Asn Arg Arg Ser Asp Glu Pro 
225                 230                 235                 240 


Ala Lys Xaa Lys Lys Gly Leu Ser Ser Ile Leu Asp Ala Ala Arg Trp 
                245                 250                 255     


Asn Arg Gly Glu Pro Gln Val Pro Asp Phe Arg His Leu Lys Ala Glu 
            260                 265                 270         


Val Asp Ala Glu Lys Pro Gly Ala Xaa Asp Arg Lys Gly Gly Val Gly 
        275                 280                 285             


Met Pro Ser Arg Asp Arg Asn Ile Gly Ala Pro Gly Gln Asp Xaa Pro 
    290                 295                 300                 


Gly Val Ser Leu His Pro Leu Ser Leu Asp Ser Pro Asp Arg Glu Pro 
305                 310                 315                 320 


Gly Ala Asp Ala Pro Leu Glu Leu Gly Asp Ser Ser Pro Gln Gly Pro 
                325                 330                 335     


Met Ser Leu Glu Ser Leu Ala Pro Pro Glu Ser Xaa Asp Glu Gly Ala 
            340                 345                 350         


Glu Xaa Glu Ser Pro Glu Pro Gly Asp Glu Gly Glu Pro Gly Arg Ser 
        355                 360                 365             


Gly Leu Glu Leu Glu Pro Glu Glu Pro Pro Gly Trp Arg Glu Leu Val 
    370                 375                 380                 


Pro Pro Asp Xaa Leu His Ser Leu Pro Lys Ser Gln Val Lys Arg Gln 
385                 390                 395                 400 


Glu Val Ile Ser Glu Leu Leu Val Xaa Glu Ala Ala His Val Arg Met 
                405                 410                 415     


Leu Arg Val Leu His Asp Leu Phe Phe Gln Pro Met Ala Glu Cys Leu 
            420                 425                 430         


Phe Phe Pro Leu Glu Glu Leu Gln Asn Ile Phe Pro Ser Leu Asp Glu 
        435                 440                 445             


Leu Ile Glu Val His Ser Leu Phe Leu Asp Arg Leu Met Lys Arg Arg 
    450                 455                 460                 


Gln Glu Ser Gly Tyr Leu Ile Glu Glu Ile Gly Asp Val Leu Leu Ala 
465                 470                 475                 480 


Arg Phe Asp Gly Ala Glu Gly Ser Trp Phe Gln Lys Ile Ser Ser Arg 
                485                 490                 495     


Phe Cys Ser Arg Gln Ser Phe Ala Leu Glu Gln Leu Lys Ala Lys Gln 
            500                 505                 510         


Arg Lys Asp Pro Arg Phe Cys Ala Phe Val Gln Glu Ala Glu Ser Arg 
        515                 520                 525             


Pro Arg Cys Arg Arg Leu Gln Leu Lys Asp Met Ile Pro Xaa Glu Met 
    530                 535                 540                 


Gln Arg Leu Xaa Lys Tyr Pro Leu Leu Leu Gln Ser Ile Gly Gln Asn 
545                 550                 555                 560 


Xaa Glu Glu Pro Xaa Glu Arg Glu Lys Val Glu Leu Ala Ala Glu Cys 
                565                 570                 575     


Cys Arg Glu Ile Leu His His Val Asn Gln Ala Val Arg Asp Met Glu 
            580                 585                 590         


Asp Leu Leu Arg Leu Lys Asp Tyr Gln Arg Arg Leu Asp Leu Ser His 
        595                 600                 605             


Leu Arg Gln Ser Ser Asp Pro Met Leu Ser Glu Phe Lys Asn Leu Asp 
    610                 615                 620                 


Ile Xaa Lys Lys Lys Leu Val His Glu Gly Pro Leu Xaa Trp Arg Val 
625                 630                 635                 640 


Xaa Lys Asp Lys Ala Val Glu Val His Val Leu Leu Leu Asp Asp Leu 
                645                 650                 655     


Leu Leu Leu Leu Gln Arg Gln Asp Glu Arg Leu Leu Leu Lys Ser His 
            660                 665                 670         


Ser Arg Xaa Leu Xaa Pro Xaa Pro Asp Gly Lys Xaa Met Leu Arg Pro 
        675                 680                 685             


Val Leu Arg Leu Xaa Ser Ala Met Xaa Arg Glu Val Ala Xaa Asp His 
    690                 695                 700                 


Lys Ala Phe Tyr Val Leu Phe Xaa Trp Asp Gln Glu Ala Gln Ile Tyr 
705                 710                 715                 720 


Glu Leu Val Ala Gln Xaa Val Ser Glu Arg Lys Asn Trp Cys Ala Leu 
                725                 730                 735     


Ile Xaa Glu Xaa Ala Gly Ser Leu Lys Val Pro Ala Pro Ala Ser Arg 
            740                 745                 750         


Pro Lys Pro Arg Pro Ser Pro Ser Ser Xaa Arg Glu Pro Leu Leu Ser 
        755                 760                 765             


Ser Ser Glu Asn Gly Asn Gly Gly Arg Glu Xaa Ser Pro Ala Asp Ala 
    770                 775                 780                 


Arg Xaa Glu Arg Ile Leu Ser Asp Leu Leu Pro Phe Cys Arg Pro Gly 
785                 790                 795                 800 


Pro Glu Gly Gln Leu Ala Ala Xaa Ala Leu Arg Lys Gly Val Gly Gly 
                805                 810                 815     


Gly Ile Leu Pro Pro Glu Xaa Pro Pro Val Ser Ala Trp Gly Glu Leu 
            820                 825                 830         


Cys Pro Pro Ala Trp Leu His Leu Arg Phe Pro Pro Arg Lys Ala Phe 
        835                 840                 845             


Cys Lys Lys Glu Arg Asn Gly Gly Glu Asp Val Arg Asp His Pro His 
    850                 855                 860                 


Pro His Ser Cys Arg Ser Ile Ser His Pro Glu Gly Leu Arg Arg Gly 
865                 870                 875                 880 


Ser Cys Gly Pro Arg Leu Gly Gly Ala Gln Leu Gly Leu Leu Ala Pro 
                885                 890                 895     


His Glu Pro Arg Pro Ser Leu Pro Pro Ala Leu Cys Leu Gly Asp Ser 
            900                 905                 910         


Gly Leu His Ser Gly Gly His His Gly Asp Pro Gly His Leu Ser Ile 
        915                 920                 925             


Ala Cys Gly Gly His Pro Ser Xaa Pro Xaa Pro Lys Cys Leu Arg Ser 
    930                 935                 940                 


Val Phe Ile Pro 
945             


<210> 2946
<211> 912
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<400> 2946
Met Glu Asp Phe Ala Arg Gly Ala Ala Ser Pro Gly Pro Ser Arg Pro 
1               5                   10                  15      


Gly Leu Val Pro Val Ser Ile Ile Gly Ala Glu Asp Glu Asp Phe Glu 
            20                  25                  30          


Asn Glu Leu Glu Xaa Asn Ser Glu Glu Gln Asn Ser Gln Phe Gln Ser 
        35                  40                  45              


Leu Glu Gln Val Lys Arg Arg Pro Ala His Leu Met Ala Leu Leu Gln 
    50                  55                  60                  


His Val Ala Leu Gln Phe Glu Pro Gly Pro Leu Leu Cys Cys Leu His 
65                  70                  75                  80  


Ala Asp Met Leu Gly Ser Leu Gly Pro Lys Glu Ala Lys Lys Ala Phe 
                85                  90                  95      


Leu Asp Phe Tyr His Ser Phe Leu Glu Lys Xaa Ala Val Leu Arg Val 
            100                 105                 110         


Pro Val Pro Pro Asn Val Ala Phe Glu Leu Asp Arg Xaa Arg Ala Asp 
        115                 120                 125             


Leu Ile Ser Glu Asp Val Gln Arg Arg Phe Val Gln Glu Val Val Gln 
    130                 135                 140                 


Ser Gln Gln Val Ala Val Gly Arg Gln Leu Glu Asp Phe Arg Ser Lys 
145                 150                 155                 160 


Arg Leu Met Gly Met Xaa Pro Trp Glu Gln Glu Leu Ala Gln Leu Glu 
                165                 170                 175     


Ala Trp Val Gly Arg Asp Arg Ala Ser Tyr Glu Ala Arg Glu Arg His 
            180                 185                 190         


Val Ala Glu Arg Leu Leu Met His Leu Glu Glu Met Gln His Xaa Ile 
        195                 200                 205             


Ser Xaa Asp Glu Glu Lys Ser Ala Ala Val Val Asn Ala Ile Gly Leu 
    210                 215                 220                 


Tyr Met Arg His Leu Gly Val Arg Xaa Lys Ser Gly Asp Lys Lys Ser 
225                 230                 235                 240 


Gly Arg Asn Phe Phe Arg Lys Lys Val Met Gly Asn Arg Arg Ser Asp 
                245                 250                 255     


Glu Pro Ala Lys Xaa Lys Lys Gly Leu Ser Ser Ile Leu Asp Ala Ala 
            260                 265                 270         


Arg Trp Asn Arg Gly Glu Pro Gln Val Pro Asp Phe Arg His Leu Lys 
        275                 280                 285             


Ala Glu Val Asp Ala Glu Lys Pro Gly Ala Xaa Asp Arg Lys Gly Gly 
    290                 295                 300                 


Val Gly Met Pro Ser Arg Asp Arg Asn Ile Gly Ala Pro Gly Gln Asp 
305                 310                 315                 320 


Xaa Pro Gly Val Ser Leu His Pro Leu Ser Leu Asp Ser Pro Asp Arg 
                325                 330                 335     


Glu Pro Gly Ala Asp Ala Pro Leu Glu Leu Gly Asp Ser Ser Pro Gln 
            340                 345                 350         


Gly Pro Met Ser Leu Glu Ser Leu Ala Pro Pro Glu Ser Xaa Asp Glu 
        355                 360                 365             


Gly Ala Glu Xaa Glu Ser Pro Glu Pro Gly Asp Glu Gly Glu Pro Gly 
    370                 375                 380                 


Arg Ser Gly Leu Glu Leu Glu Pro Glu Glu Pro Pro Gly Trp Arg Glu 
385                 390                 395                 400 


Leu Val Pro Pro Asp Xaa Leu His Ser Leu Pro Lys Ser Gln Val Lys 
                405                 410                 415     


Arg Gln Glu Val Ile Ser Glu Leu Leu Val Xaa Glu Ala Ala His Val 
            420                 425                 430         


Arg Met Leu Arg Val Leu His Asp Leu Phe Phe Gln Pro Met Ala Glu 
        435                 440                 445             


Cys Leu Phe Phe Pro Leu Glu Glu Leu Gln Asn Ile Phe Pro Ser Leu 
    450                 455                 460                 


Asp Glu Leu Ile Glu Val His Ser Leu Phe Leu Asp Arg Leu Met Lys 
465                 470                 475                 480 


Arg Arg Gln Glu Ser Gly Tyr Leu Ile Glu Glu Ile Gly Asp Val Leu 
                485                 490                 495     


Leu Ala Arg Phe Asp Gly Ala Glu Gly Ser Trp Phe Gln Lys Ile Ser 
            500                 505                 510         


Ser Arg Phe Cys Ser Arg Gln Ser Phe Ala Leu Glu Gln Leu Lys Ala 
        515                 520                 525             


Lys Gln Arg Lys Asp Pro Arg Phe Cys Ala Phe Val Gln Glu Ala Glu 
    530                 535                 540                 


Ser Arg Pro Arg Cys Arg Arg Leu Gln Leu Lys Asp Met Ile Pro Xaa 
545                 550                 555                 560 


Glu Met Gln Arg Leu Xaa Lys Tyr Pro Leu Leu Leu Gln Ser Ile Gly 
                565                 570                 575     


Gln Asn Xaa Glu Glu Pro Xaa Glu Arg Glu Lys Val Glu Leu Ala Ala 
            580                 585                 590         


Glu Cys Cys Arg Glu Ile Leu His His Val Asn Gln Ala Val Arg Asp 
        595                 600                 605             


Met Glu Asp Leu Leu Arg Leu Lys Asp Tyr Gln Arg Arg Leu Asp Leu 
    610                 615                 620                 


Ser His Leu Arg Gln Ser Ser Asp Pro Met Leu Ser Glu Phe Lys Asn 
625                 630                 635                 640 


Leu Asp Ile Xaa Lys Lys Lys Leu Val His Glu Gly Pro Leu Xaa Trp 
                645                 650                 655     


Arg Val Xaa Lys Asp Lys Ala Val Glu Val His Val Leu Leu Leu Asp 
            660                 665                 670         


Asp Leu Leu Leu Leu Leu Gln Arg Gln Asp Glu Arg Leu Leu Leu Lys 
        675                 680                 685             


Ser His Ser Arg Xaa Leu Xaa Pro Xaa Pro Asp Gly Lys Xaa Met Leu 
    690                 695                 700                 


Arg Pro Val Leu Arg Leu Xaa Ser Ala Met Xaa Arg Glu Val Ala Xaa 
705                 710                 715                 720 


Asp His Lys Ala Phe Tyr Val Leu Phe Xaa Trp Asp Gln Glu Ala Gln 
                725                 730                 735     


Ile Tyr Glu Leu Val Ala Gln Xaa Val Ser Glu Arg Lys Asn Trp Cys 
            740                 745                 750         


Ala Leu Ile Xaa Glu Xaa Ala Gly Ser Leu Lys Val Pro Ala Pro Ala 
        755                 760                 765             


Ser Arg Pro Lys Pro Arg Pro Ser Pro Ser Ser Xaa Arg Glu Pro Leu 
    770                 775                 780                 


Leu Ser Ser Ser Glu Asn Gly Asn Gly Gly Arg Glu Xaa Ser Pro Ala 
785                 790                 795                 800 


Asp Ala Arg Xaa Glu Arg Ile Leu Ser Asp Leu Leu Pro Phe Cys Arg 
                805                 810                 815     


Pro Gly Pro Glu Gly Gln Leu Ala Ala Xaa Ala Leu Arg Lys Val Leu 
            820                 825                 830         


Ser Leu Lys Gln Leu Leu Phe Pro Ala Glu Glu Asp Asn Gly Ala Gly 
        835                 840                 845             


Pro Pro Arg Asp Gly Asp Gly Val Pro Gly Gly Gly Pro Leu Ser Pro 
    850                 855                 860                 


Ala Arg Xaa Gln Glu Ile Gln Glu Asn Leu Leu Ser Leu Glu Glu Xaa 
865                 870                 875                 880 


Met Lys Gln Leu Glu Glu Leu Glu Glu Glu Phe Cys Arg Leu Arg Pro 
                885                 890                 895     


Leu Leu Ser Gln Leu Gly Gly Asn Ser Val Pro Gln Pro Gly Cys Xaa 
            900                 905                 910         


<210> 2947
<211> 968
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(968)
<223> Selenocysteine

<400> 2947
Met Glu Asp Phe Ala Arg Gly Ala Ala Ser Pro Gly Pro Ser Arg Pro 
1               5                   10                  15      


Gly Leu Val Pro Val Ser Ile Ile Gly Ala Glu Asp Glu Asp Phe Glu 
            20                  25                  30          


Asn Glu Leu Glu Xaa Asn Ser Glu Glu Gln Asn Ser Gln Phe Gln Ser 
        35                  40                  45              


Leu Glu Gln Val Lys Arg Arg Pro Ala His Leu Met Ala Leu Leu Gln 
    50                  55                  60                  


His Val Ala Leu Gln Phe Glu Pro Gly Pro Leu Leu Cys Cys Leu His 
65                  70                  75                  80  


Ala Asp Met Leu Gly Ser Leu Gly Pro Lys Glu Ala Lys Lys Ala Phe 
                85                  90                  95      


Leu Asp Phe Tyr His Ser Phe Leu Glu Lys Xaa Ala Val Leu Arg Val 
            100                 105                 110         


Pro Val Pro Pro Asn Val Ala Phe Glu Leu Asp Arg Xaa Arg Ala Asp 
        115                 120                 125             


Leu Ile Ser Glu Asp Val Gln Arg Arg Phe Val Gln Glu Val Val Gln 
    130                 135                 140                 


Ser Gln Gln Val Ala Val Gly Arg Gln Leu Glu Asp Phe Arg Ser Lys 
145                 150                 155                 160 


Arg Leu Met Gly Met Xaa Pro Trp Glu Gln Glu Leu Ala Gln Leu Glu 
                165                 170                 175     


Ala Trp Val Gly Arg Asp Arg Ala Ser Tyr Glu Ala Arg Glu Arg His 
            180                 185                 190         


Val Ala Glu Arg Leu Leu Met His Leu Glu Glu Met Gln His Xaa Ile 
        195                 200                 205             


Ser Xaa Asp Glu Glu Lys Ser Ala Ala Val Val Asn Ala Ile Gly Leu 
    210                 215                 220                 


Tyr Met Arg His Leu Gly Val Arg Xaa Lys Ser Gly Asp Lys Lys Ser 
225                 230                 235                 240 


Gly Arg Asn Phe Phe Arg Lys Lys Val Met Gly Asn Arg Arg Ser Asp 
                245                 250                 255     


Glu Pro Ala Lys Xaa Lys Lys Gly Leu Ser Ser Ile Leu Asp Ala Ala 
            260                 265                 270         


Arg Trp Asn Arg Gly Glu Pro Gln Val Pro Asp Phe Arg His Leu Lys 
        275                 280                 285             


Ala Glu Val Asp Ala Glu Lys Pro Gly Ala Xaa Asp Arg Lys Gly Gly 
    290                 295                 300                 


Val Gly Met Pro Ser Arg Asp Arg Asn Ile Gly Ala Pro Gly Gln Asp 
305                 310                 315                 320 


Xaa Pro Gly Val Ser Leu His Pro Leu Ser Leu Asp Ser Pro Asp Arg 
                325                 330                 335     


Glu Pro Gly Ala Asp Ala Pro Leu Glu Leu Gly Asp Ser Ser Pro Gln 
            340                 345                 350         


Gly Pro Met Ser Leu Glu Ser Leu Ala Pro Pro Glu Ser Xaa Asp Glu 
        355                 360                 365             


Gly Ala Glu Xaa Glu Arg Leu Ser Gly Arg Leu Gly Arg Ser Glu Ser 
    370                 375                 380                 


Leu Arg Val Ser Asp Arg Arg Arg Pro Ser Arg Gly Ser Leu Gly Ala 
385                 390                 395                 400 


Lys Gly Arg Gly Gly Gly Arg Ser Arg Ser Asp Val Asp Met Asp Pro 
                405                 410                 415     


Ser Ser Ala Xaa Ala Val Leu Gly Pro Ala Arg Arg Ala Xaa Pro Glu 
            420                 425                 430         


Pro Gly Asp Glu Gly Glu Pro Gly Arg Ser Gly Leu Glu Leu Glu Pro 
        435                 440                 445             


Glu Glu Pro Pro Gly Trp Arg Glu Leu Val Pro Pro Asp Xaa Leu His 
    450                 455                 460                 


Ser Leu Pro Lys Ser Gln Val Lys Arg Gln Glu Val Ile Ser Glu Leu 
465                 470                 475                 480 


Leu Val Xaa Glu Ala Ala His Val Arg Met Leu Arg Val Leu His Asp 
                485                 490                 495     


Leu Phe Phe Gln Pro Met Ala Glu Cys Leu Phe Phe Pro Leu Glu Glu 
            500                 505                 510         


Leu Gln Asn Ile Phe Pro Ser Leu Asp Glu Leu Ile Glu Val His Ser 
        515                 520                 525             


Leu Phe Leu Asp Arg Leu Met Lys Arg Arg Gln Glu Ser Gly Tyr Leu 
    530                 535                 540                 


Ile Glu Glu Ile Gly Asp Val Leu Leu Ala Arg Phe Asp Gly Ala Glu 
545                 550                 555                 560 


Gly Ser Trp Phe Gln Lys Ile Ser Ser Arg Phe Cys Ser Arg Gln Ser 
                565                 570                 575     


Phe Ala Leu Glu Gln Leu Lys Ala Lys Gln Arg Lys Asp Pro Arg Phe 
            580                 585                 590         


Cys Ala Phe Val Gln Glu Ala Glu Ser Arg Pro Arg Cys Arg Arg Leu 
        595                 600                 605             


Gln Leu Lys Asp Met Ile Pro Xaa Glu Met Gln Arg Leu Xaa Lys Tyr 
    610                 615                 620                 


Pro Leu Leu Leu Gln Ser Ile Gly Gln Asn Xaa Glu Glu Pro Xaa Glu 
625                 630                 635                 640 


Arg Glu Lys Val Glu Leu Ala Ala Glu Cys Cys Arg Glu Ile Leu His 
                645                 650                 655     


His Val Asn Gln Ala Val Arg Asp Met Glu Asp Leu Leu Arg Leu Lys 
            660                 665                 670         


Asp Tyr Gln Arg Arg Leu Asp Leu Ser His Leu Arg Gln Ser Ser Asp 
        675                 680                 685             


Pro Met Leu Ser Glu Phe Lys Asn Leu Asp Ile Xaa Lys Lys Lys Leu 
    690                 695                 700                 


Val His Glu Gly Pro Leu Xaa Trp Arg Val Xaa Lys Asp Lys Ala Val 
705                 710                 715                 720 


Glu Val His Val Leu Leu Leu Asp Asp Leu Leu Leu Leu Leu Gln Arg 
                725                 730                 735     


Gln Asp Glu Arg Leu Leu Leu Lys Ser His Ser Arg Xaa Leu Xaa Pro 
            740                 745                 750         


Xaa Pro Asp Gly Lys Xaa Met Leu Arg Pro Val Leu Arg Leu Xaa Ser 
        755                 760                 765             


Ala Met Xaa Arg Glu Val Ala Xaa Asp His Lys Ala Phe Tyr Val Leu 
    770                 775                 780                 


Phe Xaa Trp Asp Gln Glu Ala Gln Ile Tyr Glu Leu Val Ala Gln Xaa 
785                 790                 795                 800 


Val Ser Glu Arg Lys Asn Trp Cys Ala Leu Ile Xaa Glu Xaa Ala Gly 
                805                 810                 815     


Ser Leu Lys Val Pro Ala Pro Ala Ser Arg Pro Lys Pro Arg Pro Ser 
            820                 825                 830         


Pro Ser Ser Xaa Arg Glu Pro Leu Leu Ser Ser Ser Glu Asn Gly Asn 
        835                 840                 845             


Gly Gly Arg Glu Xaa Ser Pro Ala Asp Ala Arg Xaa Glu Arg Ile Leu 
    850                 855                 860                 


Ser Asp Leu Leu Pro Phe Cys Arg Pro Gly Pro Glu Gly Gln Leu Ala 
865                 870                 875                 880 


Ala Xaa Ala Leu Arg Lys Val Leu Ser Leu Lys Gln Leu Leu Phe Pro 
                885                 890                 895     


Ala Glu Glu Asp Asn Gly Ala Gly Pro Pro Arg Asp Gly Asp Gly Val 
            900                 905                 910         


Pro Gly Gly Gly Pro Leu Ser Pro Ala Arg Xaa Gln Glu Ile Gln Glu 
        915                 920                 925             


Asn Leu Leu Ser Leu Glu Glu Xaa Met Lys Gln Leu Glu Glu Leu Glu 
    930                 935                 940                 


Glu Glu Phe Cys Arg Leu Arg Pro Leu Leu Ser Gln Leu Gly Gly Asn 
945                 950                 955                 960 


Ser Val Pro Gln Pro Gly Cys Xaa 
                965             


<210> 2948
<211> 879
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<400> 2948
Met Glu Asp Phe Ala Arg Gly Ala Ala Ser Pro Gly Pro Ser Arg Pro 
1               5                   10                  15      


Gly Leu Val Pro Val Ser Ile Ile Gly Ala Glu Asp Glu Asp Phe Glu 
            20                  25                  30          


Asn Glu Leu Glu Xaa Asn Ser Glu Glu Gln Asn Ser Gln Phe Gln Ser 
        35                  40                  45              


Leu Glu Gln Val Lys Arg Arg Pro Ala His Leu Met Ala Leu Leu Gln 
    50                  55                  60                  


His Val Ala Leu Gln Phe Glu Pro Gly Pro Leu Val Leu Arg Val Pro 
65                  70                  75                  80  


Val Pro Pro Asn Val Ala Phe Glu Leu Asp Arg Xaa Arg Ala Asp Leu 
                85                  90                  95      


Ile Ser Glu Asp Val Gln Arg Arg Phe Val Gln Glu Val Val Gln Ser 
            100                 105                 110         


Gln Gln Val Ala Val Gly Arg Gln Leu Glu Asp Phe Arg Ser Lys Arg 
        115                 120                 125             


Leu Met Gly Met Xaa Pro Trp Glu Gln Glu Leu Ala Gln Leu Glu Ala 
    130                 135                 140                 


Trp Val Gly Arg Asp Arg Ala Ser Tyr Glu Ala Arg Glu Arg His Val 
145                 150                 155                 160 


Ala Glu Arg Leu Leu Met His Leu Glu Glu Met Gln His Xaa Ile Ser 
                165                 170                 175     


Xaa Asp Glu Glu Lys Ser Ala Ala Val Val Asn Ala Ile Gly Leu Tyr 
            180                 185                 190         


Met Arg His Leu Gly Val Arg Xaa Lys Ser Gly Asp Lys Lys Ser Gly 
        195                 200                 205             


Arg Asn Phe Phe Arg Lys Lys Val Met Gly Asn Arg Arg Ser Asp Glu 
    210                 215                 220                 


Pro Ala Lys Xaa Lys Lys Gly Leu Ser Ser Ile Leu Asp Ala Ala Arg 
225                 230                 235                 240 


Trp Asn Arg Gly Glu Pro Gln Val Pro Asp Phe Arg His Leu Lys Ala 
                245                 250                 255     


Glu Val Asp Ala Glu Lys Pro Gly Ala Xaa Asp Arg Lys Gly Gly Val 
            260                 265                 270         


Gly Met Pro Ser Arg Asp Arg Asn Ile Gly Ala Pro Gly Gln Asp Xaa 
        275                 280                 285             


Pro Gly Val Ser Leu His Pro Leu Ser Leu Asp Ser Pro Asp Arg Glu 
    290                 295                 300                 


Pro Gly Ala Asp Ala Pro Leu Glu Leu Gly Asp Ser Ser Pro Gln Gly 
305                 310                 315                 320 


Pro Met Ser Leu Glu Ser Leu Ala Pro Pro Glu Ser Xaa Asp Glu Gly 
                325                 330                 335     


Ala Glu Xaa Glu Ser Pro Glu Pro Gly Asp Glu Gly Glu Pro Gly Arg 
            340                 345                 350         


Ser Gly Leu Glu Leu Glu Pro Glu Glu Pro Pro Gly Trp Arg Glu Leu 
        355                 360                 365             


Val Pro Pro Asp Xaa Leu His Ser Leu Pro Lys Ser Gln Val Lys Arg 
    370                 375                 380                 


Gln Glu Val Ile Ser Glu Leu Leu Val Xaa Glu Ala Ala His Val Arg 
385                 390                 395                 400 


Met Leu Arg Val Leu His Asp Leu Phe Phe Gln Pro Met Ala Glu Cys 
                405                 410                 415     


Leu Phe Phe Pro Leu Glu Glu Leu Gln Asn Ile Phe Pro Ser Leu Asp 
            420                 425                 430         


Glu Leu Ile Glu Val His Ser Leu Phe Leu Asp Arg Leu Met Lys Arg 
        435                 440                 445             


Arg Gln Glu Ser Gly Tyr Leu Ile Glu Glu Ile Gly Asp Val Leu Leu 
    450                 455                 460                 


Ala Arg Phe Asp Gly Ala Glu Gly Ser Trp Phe Gln Lys Ile Ser Ser 
465                 470                 475                 480 


Arg Phe Cys Ser Arg Gln Ser Phe Ala Leu Glu Gln Leu Lys Ala Lys 
                485                 490                 495     


Gln Arg Lys Asp Pro Arg Phe Cys Ala Phe Val Gln Glu Ala Glu Ser 
            500                 505                 510         


Arg Pro Arg Cys Arg Arg Leu Gln Leu Lys Asp Met Ile Pro Xaa Glu 
        515                 520                 525             


Met Gln Arg Leu Xaa Lys Tyr Pro Leu Leu Leu Gln Ser Ile Gly Gln 
    530                 535                 540                 


Asn Xaa Glu Glu Pro Xaa Glu Arg Glu Lys Val Glu Leu Ala Ala Glu 
545                 550                 555                 560 


Cys Cys Arg Glu Ile Leu His His Val Asn Gln Ala Val Arg Asp Met 
                565                 570                 575     


Glu Asp Leu Leu Arg Leu Lys Asp Tyr Gln Arg Arg Leu Asp Leu Ser 
            580                 585                 590         


His Leu Arg Gln Ser Ser Asp Pro Met Leu Ser Glu Phe Lys Asn Leu 
        595                 600                 605             


Asp Ile Xaa Lys Lys Lys Leu Val His Glu Gly Pro Leu Xaa Trp Arg 
    610                 615                 620                 


Val Xaa Lys Asp Lys Ala Val Glu Val His Val Leu Leu Leu Asp Asp 
625                 630                 635                 640 


Leu Leu Leu Leu Leu Gln Arg Gln Asp Glu Arg Leu Leu Leu Lys Ser 
                645                 650                 655     


His Ser Arg Xaa Leu Xaa Pro Xaa Pro Asp Gly Lys Xaa Met Leu Arg 
            660                 665                 670         


Pro Val Leu Arg Leu Xaa Ser Ala Met Xaa Arg Glu Val Ala Xaa Asp 
        675                 680                 685             


His Lys Ala Phe Tyr Val Leu Phe Xaa Trp Asp Gln Glu Ala Gln Ile 
    690                 695                 700                 


Tyr Glu Leu Val Ala Gln Xaa Val Ser Glu Arg Lys Asn Trp Cys Ala 
705                 710                 715                 720 


Leu Ile Xaa Glu Xaa Ala Gly Ser Leu Lys Val Pro Ala Pro Ala Ser 
                725                 730                 735     


Arg Pro Lys Pro Arg Pro Ser Pro Ser Ser Xaa Arg Glu Pro Leu Leu 
            740                 745                 750         


Ser Ser Ser Glu Asn Gly Asn Gly Gly Arg Glu Xaa Ser Pro Ala Asp 
        755                 760                 765             


Ala Arg Xaa Glu Arg Ile Leu Ser Asp Leu Leu Pro Phe Cys Arg Pro 
    770                 775                 780                 


Gly Pro Glu Gly Gln Leu Ala Ala Xaa Ala Leu Arg Lys Val Leu Ser 
785                 790                 795                 800 


Leu Lys Gln Leu Leu Phe Pro Ala Glu Glu Asp Asn Gly Ala Gly Pro 
                805                 810                 815     


Pro Arg Asp Gly Asp Gly Val Pro Gly Gly Gly Pro Leu Ser Pro Ala 
            820                 825                 830         


Arg Xaa Gln Glu Ile Gln Glu Asn Leu Leu Ser Leu Glu Glu Xaa Met 
        835                 840                 845             


Lys Gln Leu Glu Glu Leu Glu Glu Glu Phe Cys Arg Leu Arg Pro Leu 
    850                 855                 860                 


Leu Ser Gln Leu Gly Gly Asn Ser Val Pro Gln Pro Gly Cys Xaa 
865                 870                 875                 


<210> 2949
<211> 702
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<400> 2949
Xaa Gly Val Gly Met Pro Ser Arg Asp Arg Asn Ile Gly Ala Pro Gly 
1               5                   10                  15      


Gln Asp Xaa Pro Gly Val Ser Leu His Pro Leu Ser Leu Asp Ser Pro 
            20                  25                  30          


Asp Arg Glu Pro Gly Ala Asp Ala Pro Leu Glu Leu Gly Asp Ser Ser 
        35                  40                  45              


Pro Gln Gly Pro Met Ser Leu Glu Ser Leu Ala Pro Pro Glu Ser Xaa 
    50                  55                  60                  


Asp Glu Gly Ala Glu Xaa Glu Arg Arg Trp Lys Arg Leu Ser Gly Arg 
65                  70                  75                  80  


Leu Gly Arg Ser Glu Ser Leu Arg Val Ser Asp Arg Arg Arg Pro Ser 
                85                  90                  95      


Arg Gly Ser Leu Gly Ala Lys Gly Arg Gly Gly Gly Arg Ser Arg Ser 
            100                 105                 110         


Asp Val Asp Met Asp Pro Ser Ser Ala Xaa Ala Val Leu Gly Pro Ala 
        115                 120                 125             


Arg Arg Ala Xaa Pro Glu Pro Gly Asp Glu Gly Glu Pro Gly Arg Ser 
    130                 135                 140                 


Gly Leu Glu Leu Glu Pro Glu Glu Pro Pro Gly Trp Arg Glu Leu Val 
145                 150                 155                 160 


Pro Pro Asp Xaa Leu His Ser Leu Pro Lys Ser Gln Val Lys Arg Gln 
                165                 170                 175     


Glu Val Ile Ser Glu Leu Leu Val Xaa Glu Ala Ala His Val Arg Met 
            180                 185                 190         


Leu Arg Val Leu His Asp Leu Phe Phe Gln Pro Met Ala Glu Cys Leu 
        195                 200                 205             


Phe Phe Pro Leu Glu Glu Leu Gln Asn Ile Phe Pro Ser Leu Asp Glu 
    210                 215                 220                 


Leu Ile Glu Val His Ser Leu Phe Leu Asp Arg Leu Met Lys Arg Arg 
225                 230                 235                 240 


Gln Glu Ser Gly Tyr Leu Ile Glu Glu Ile Gly Asp Val Leu Leu Ala 
                245                 250                 255     


Arg Phe Asp Gly Ala Glu Gly Ser Trp Phe Gln Lys Ile Ser Ser Arg 
            260                 265                 270         


Phe Cys Ser Arg Gln Ser Phe Ala Leu Glu Gln Leu Lys Ala Lys Gln 
        275                 280                 285             


Arg Lys Asp Pro Arg Phe Cys Ala Phe Val Gln Glu Ala Glu Ser Arg 
    290                 295                 300                 


Pro Arg Cys Arg Arg Leu Gln Leu Lys Asp Met Ile Pro Xaa Glu Met 
305                 310                 315                 320 


Gln Arg Leu Xaa Lys Tyr Pro Leu Leu Leu Gln Ser Ile Gly Gln Asn 
                325                 330                 335     


Xaa Glu Glu Pro Xaa Glu Arg Glu Lys Val Glu Leu Ala Ala Glu Cys 
            340                 345                 350         


Cys Arg Glu Ile Leu His His Val Asn Gln Ala Val Arg Asp Met Glu 
        355                 360                 365             


Asp Leu Leu Arg Leu Lys Asp Tyr Gln Arg Arg Leu Asp Leu Ser His 
    370                 375                 380                 


Leu Arg Gln Ser Ser Asp Pro Met Leu Ser Glu Phe Lys Asn Leu Asp 
385                 390                 395                 400 


Ile Xaa Lys Lys Lys Leu Val His Glu Gly Pro Leu Xaa Trp Arg Val 
                405                 410                 415     


Xaa Lys Asp Lys Ala Val Glu Val His Val Leu Leu Leu Asp Asp Leu 
            420                 425                 430         


Leu Leu Leu Leu Gln Arg Gln Asp Glu Arg Leu Leu Leu Lys Ser His 
        435                 440                 445             


Ser Arg Xaa Leu Xaa Pro Xaa Pro Asp Gly Lys Xaa Met Leu Arg Pro 
    450                 455                 460                 


Val Leu Arg Leu Xaa Ser Ala Met Xaa Arg Glu Val Ala Xaa Asp His 
465                 470                 475                 480 


Lys Ala Phe Tyr Val Leu Phe Xaa Trp Asp Gln Glu Ala Gln Ile Tyr 
                485                 490                 495     


Glu Leu Val Ala Gln Xaa Val Ser Glu Arg Lys Asn Trp Cys Ala Leu 
            500                 505                 510         


Ile Xaa Glu Xaa Ala Gly Ser Leu Lys Val Pro Ala Pro Ala Ser Arg 
        515                 520                 525             


Pro Lys Pro Arg Pro Ser Pro Ser Ser Xaa Arg Glu Pro Leu Leu Ser 
    530                 535                 540                 


Ser Ser Glu Asn Gly Asn Gly Gly Arg Glu Xaa Ser Pro Ala Asp Ala 
545                 550                 555                 560 


Arg Xaa Glu Arg Ile Leu Ser Asp Leu Leu Pro Phe Cys Arg Pro Gly 
                565                 570                 575     


Pro Glu Gly Gln Leu Ala Ala Xaa Ala Leu Arg Lys Gly Val Gly Gly 
            580                 585                 590         


Gly Ile Leu Pro Pro Glu Xaa Pro Pro Val Ser Ala Trp Gly Glu Leu 
        595                 600                 605             


Cys Pro Pro Ala Trp Leu His Leu Arg Phe Pro Pro Arg Lys His Pro 
    610                 615                 620                 


Ile Leu Xaa Xaa Xaa Cys Glu Val Gly Xaa Ala Met Met Asp Ala His 
625                 630                 635                 640 


Phe Xaa Asp Val Glu Xaa Glu Val Leu Xaa Gly Lys Val Xaa Trp Pro 
                645                 650                 655     


Lys Ser His Arg Asp Glu Val Ser Leu Asp Leu Asn Ala Gly Ala Arg 
            660                 665                 670         


Trp Arg Trp Arg Arg Cys Val Gln Asp Pro Cys Trp Xaa Arg Lys Pro 
        675                 680                 685             


Gly Pro Gly Leu Glu His Gly Pro Ala His Xaa Gln Pro Gly 
    690                 695                 700         


<210> 2950
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<400> 2950
Xaa Pro Ile Leu Xaa Xaa Xaa Cys Glu Val Gly Xaa Ala Met Met Asp 
1               5                   10                  15      


Ala His Phe Xaa Asp Val Glu Xaa Glu Val Leu Xaa Gly Lys Val Xaa 
            20                  25                  30          


Trp Pro Lys Ser His Arg Asp Glu Val Ser Leu Asp Leu Asn Ala Val 
        35                  40                  45              


Asp Ala Arg Xaa Asn Gly Gln Ala Arg Gly Gly Gly Gly Asp Asp Ala 
    50                  55                  60                  


Ser Arg Xaa Pro Ala Gly His Ala Ser Leu Asp Arg Asp Trp Asn Xaa 
65                  70                  75                  80  


Asp Pro His Xaa Arg Ser Leu Asp Arg Arg Tyr Xaa Asp Arg Gly Xaa 
                85                  90                  95      


Tyr Gly Tyr Ser Gln Ala Pro Pro Arg Gln Val Pro His His Leu Leu 
            100                 105                 110         


Trp Gly Lys Ala Ala Leu Xaa Trp Ala Ala Pro Gly Gly Phe Tyr Pro 
        115                 120                 125             


<210> 2951
<211> 291
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<400> 2951
Xaa Pro Arg Cys Arg Arg Leu Gln Leu Lys Asp Met Ile Pro Xaa Glu 
1               5                   10                  15      


Met Gln Arg Leu Xaa Lys Tyr Pro Leu Leu Leu Gln Ser Ile Gly Gln 
            20                  25                  30          


Asn Xaa Glu Glu Pro Xaa Glu Arg Glu Lys Val Glu Leu Ala Ala Glu 
        35                  40                  45              


Cys Cys Arg Glu Ile Leu His His Val Asn Gln Ala Val Arg Asp Met 
    50                  55                  60                  


Glu Asp Leu Leu Arg Leu Lys Asp Tyr Gln Arg Arg Leu Asp Leu Ser 
65                  70                  75                  80  


His Leu Arg Gln Ser Ser Asp Pro Met Leu Ser Glu Phe Lys Asn Leu 
                85                  90                  95      


Asp Ile Xaa Lys Lys Lys Leu Val His Glu Gly Pro Leu Xaa Trp Arg 
            100                 105                 110         


Val Xaa Lys Asp Lys Ala Val Glu Val His Val Leu Leu Leu Asp Asp 
        115                 120                 125             


Leu Leu Leu Leu Leu Gln Arg Gln Asp Glu Arg Leu Leu Leu Lys Ser 
    130                 135                 140                 


His Ser Arg Xaa Leu Xaa Pro Xaa Pro Asp Gly Lys Xaa Met Leu Arg 
145                 150                 155                 160 


Pro Val Leu Arg Leu Xaa Ser Ala Met Xaa Arg Glu Val Ala Xaa Asp 
                165                 170                 175     


His Lys Ala Phe Tyr Val Leu Phe Xaa Trp Asp Gln Glu Ala Gln Ile 
            180                 185                 190         


Tyr Glu Leu Val Ala Gln Xaa Val Ser Glu Arg Lys Asn Xaa Arg Glu 
        195                 200                 205             


Pro Leu Leu Ser Ser Ser Glu Asn Gly Asn Gly Gly Arg Glu Xaa Ser 
    210                 215                 220                 


Pro Ala Asp Ala Arg Xaa Glu Arg Ile Leu Ser Asp Leu Leu Pro Phe 
225                 230                 235                 240 


Cys Arg Pro Gly Pro Glu Gly Gln Leu Ala Ala Xaa Ala Leu Arg Lys 
                245                 250                 255     


Val Leu Ser Leu Lys Gln Leu Leu Phe Pro Ala Glu Glu Asp Asn Gly 
            260                 265                 270         


Ala Gly Pro Pro Arg Asp Gly Asp Gly Val Pro Gly Gly Gly Pro Leu 
        275                 280                 285             


Ser Pro Ala 
    290     


<210> 2952
<211> 307
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<400> 2952
Xaa Xaa Ser Val Pro Ala Leu Val Ser Pro Arg Leu Cys Pro Cys Pro 
1               5                   10                  15      


Gly Phe Ser Ser Ser Leu Phe Leu Ser Trp Ser Leu Leu Val Ser Val 
            20                  25                  30          


Pro Gly Ile Cys Leu Xaa Leu Ser Leu Ala Ser Gly Ser Arg Leu Ser 
        35                  40                  45              


Gly Arg Leu Gly Arg Ser Glu Ser Leu Arg Val Ser Asp Arg Arg Arg 
    50                  55                  60                  


Pro Ser Arg Gly Ser Leu Gly Ala Lys Gly Arg Gly Gly Gly Arg Ser 
65                  70                  75                  80  


Arg Ser Asp Val Asp Met Asp Pro Ser Ser Ala Xaa Ala Val Leu Gly 
                85                  90                  95      


Pro Ala Arg Arg Ala Xaa Pro Glu Pro Gly Asp Glu Gly Glu Pro Gly 
            100                 105                 110         


Arg Ser Gly Leu Glu Leu Glu Pro Glu Glu Pro Pro Gly Trp Arg Glu 
        115                 120                 125             


Leu Val Pro Pro Asp Xaa Leu His Ser Leu Pro Lys Ser Gln Val Lys 
    130                 135                 140                 


Arg Gln Glu Val Ile Ser Glu Leu Leu Val Xaa Glu Ala Ala His Val 
145                 150                 155                 160 


Arg Met Leu Arg Val Leu His Asp Leu Phe Phe Gln Pro Met Ala Glu 
                165                 170                 175     


Cys Leu Phe Phe Pro Leu Glu Glu Leu Gln Asn Ile Phe Pro Ser Leu 
            180                 185                 190         


Asp Glu Leu Ile Glu Val His Ser Leu Phe Leu Asp Arg Leu Met Lys 
        195                 200                 205             


Arg Arg Gln Glu Ser Gly Tyr Leu Ile Glu Glu Ile Gly Asp Val Leu 
    210                 215                 220                 


Leu Ala Arg Phe Asp Gly Ala Glu Gly Ser Trp Phe Gln Lys Ile Ser 
225                 230                 235                 240 


Ser Arg Phe Cys Ser Arg Gln Ser Phe Ala Leu Glu Gln Leu Lys Ala 
                245                 250                 255     


Lys Gln Arg Lys Asp Pro Arg Phe Cys Ala Phe Val Gln Glu Ala Glu 
            260                 265                 270         


Ser Arg Pro Arg Cys Arg Arg Leu Gln Leu Lys Asp Met Ile Pro Xaa 
        275                 280                 285             


Glu Met Gln Arg Leu Xaa Lys Tyr Pro Leu Leu Leu Gln Ser Ile Gly 
    290                 295                 300                 


Gln Asn Xaa 
305         


<210> 2953
<211> 68
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<400> 2953
Xaa Val His Val Leu Leu Leu Asp Asp Leu Leu Leu Leu Leu Gln Arg 
1               5                   10                  15      


Gln Asp Glu Arg Leu Leu Leu Lys Ser His Ser Arg Xaa Leu Xaa Pro 
            20                  25                  30          


Xaa Pro Asp Gly Lys Xaa Met Leu Arg Pro Val Leu Arg Leu Xaa Ser 
        35                  40                  45              


Ala Met Xaa Arg Glu Val Ala Xaa Ala Gly Val Leu Ser Ser Leu Arg 
    50                  55                  60                  


Leu Pro Asp Pro 
65              


<210> 2954
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<400> 2954
Xaa Val Gln Arg Arg Phe Val Gln Glu Val Val Gln Ser Gln Gln Val 
1               5                   10                  15      


Ala Val Gly Arg Gln Leu Glu Asp Phe Arg Ser Lys Arg Leu Met Gly 
            20                  25                  30          


Met Xaa Pro Trp Glu Gln Glu Leu Ala Gln Leu Glu Ala Trp Val Gly 
        35                  40                  45              


Arg Asp Arg Ala Ser Tyr Glu Ala Arg Glu Arg His Val Ala Glu Arg 
    50                  55                  60                  


Leu Leu Met His Leu Glu Glu Met Gln Xaa Ala Xaa Leu Arg Cys Ile 
65                  70                  75                  80  


Leu Gly Gly Trp Gly Pro Gln Ala 
                85              


<210> 2955
<211> 988
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<400> 2955
Ala Lys Asp Gly Xaa Lys Asp Gly Leu Glu Arg Xaa Arg Ala Ala Val 
1               5                   10                  15      


Lys Arg Gly Arg Ser Phe Ile Arg Xaa Lys Ser Leu Ile Ala Gln Asp 
            20                  25                  30          


His Arg Ser Ser Leu Glu Glu Glu Gln Asn Leu Phe Ile Asp Val Asp 
        35                  40                  45              


Cys Lys His Pro Glu Ala Ile Leu Xaa Pro Met Pro Glu Gly Leu Ser 
    50                  55                  60                  


Gln Gln Gln Val Val Arg Arg Tyr Ile Leu Gly Ser Val Val Asp Ser 
65                  70                  75                  80  


Glu Lys Asn Tyr Val Asp Ala Leu Lys Arg Ile Leu Glu Gln Tyr Glu 
                85                  90                  95      


Lys Pro Leu Ser Glu Met Glu Pro Lys Val Leu Ser Glu Arg Lys Leu 
            100                 105                 110         


Lys Xaa Val Phe Tyr Arg Val Lys Glu Ile Leu Gln Cys His Ser Leu 
        115                 120                 125             


Phe Gln Ile Ala Leu Ala Ser Arg Val Ser Glu Trp Asp Ser Val Glu 
    130                 135                 140                 


Met Ile Gly Asp Val Phe Val Ala Ser Phe Ser Lys Ser Met Val Leu 
145                 150                 155                 160 


Asp Ala Tyr Ser Glu Tyr Val Asn Asn Phe Ser Xaa Ala Val Ala Val 
                165                 170                 175     


Leu Lys Lys Xaa Cys Ala Xaa Lys Pro Ala Phe Leu Glu Phe Leu Lys 
            180                 185                 190         


Gln Glu Gln Glu Ala Ser Pro Asp Arg Xaa Xaa Leu Tyr Ser Leu Met 
        195                 200                 205             


Met Lys Pro Ile Gln Arg Phe Pro Gln Phe Ile Leu Leu Leu Gln Asp 
    210                 215                 220                 


Met Leu Lys Asn Xaa Ser Lys Gly His Pro Asp Arg Leu Pro Leu Gln 
225                 230                 235                 240 


Met Ala Leu Xaa Glu Leu Glu Xaa Leu Ala Glu Lys Leu Asn Glu Arg 
                245                 250                 255     


Lys Arg Asp Ala Asp Gln Arg Cys Glu Val Lys Gln Ile Ala Lys Ala 
            260                 265                 270         


Ile Asn Glu Arg Tyr Leu Asn Lys Leu Leu Ser Ser Gly Ser Arg Tyr 
        275                 280                 285             


Leu Ile Arg Ser Asp Asp Met Ile Glu Xaa Val Tyr Asn Asp Arg Gly 
    290                 295                 300                 


Glu Ile Val Lys Xaa Lys Glu Arg Arg Val Phe Met Leu Asn Asp Val 
305                 310                 315                 320 


Leu Met Cys Ala Xaa Val Ser Ser Arg Pro Ser His Asp Ser Arg Val 
                325                 330                 335     


Met Ser Ser Gln Arg Tyr Leu Leu Lys Trp Ser Val Pro Leu Gly His 
            340                 345                 350         


Val Asp Ala Ile Glu Tyr Gly Ser Ser Ala Gly Xaa Gly Glu His Ser 
        355                 360                 365             


Arg His Leu Ala Val His Pro Pro Glu Ser Leu Ala Val Val Ala Asn 
    370                 375                 380                 


Ala Lys Pro Asn Lys Val Tyr Met Gly Pro Gly Gln Leu Tyr Gln Asp 
385                 390                 395                 400 


Leu Gln Asn Leu Leu His Asp Leu Asn Val Ile Gly Gln Ile Xaa Gln 
                405                 410                 415     


Leu Ile Gly Asn Leu Lys Gly Asn Tyr Gln Asn Leu Asn Gln Ser Val 
            420                 425                 430         


Ala His Asp Trp Xaa Ser Gly Leu Gln Arg Leu Ile Leu Lys Lys Glu 
        435                 440                 445             


Asp Glu Ile Arg Ala Ala Asp Cys Cys Arg Ile Gln Leu Gln Leu Pro 
    450                 455                 460                 


Gly Lys Gln Asp Lys Ser Gly Arg Pro Xaa Phe Phe Xaa Ala Val Phe 
465                 470                 475                 480 


Asn Xaa Phe Xaa Pro Ala Ile Lys Glu Ser Trp Val Asn Ser Leu Gln 
                485                 490                 495     


Met Ala Lys Leu Ala Leu Glu Glu Glu Asn His Met Gly Trp Phe Cys 
            500                 505                 510         


Val Glu Asp Asp Gly Asn His Ile Lys Lys Glu Lys His Pro Leu Leu 
        515                 520                 525             


Val Gly His Met Pro Val Met Val Ala Lys Gln Gln Glu Phe Lys Ile 
    530                 535                 540                 


Gly Ser Cys Xaa His Gln Met Gly Gln Ile Ala Ile Val Ser Phe Gln 
545                 550                 555                 560 


Asn Ser Xaa Pro Lys Val Ile Glu Cys Phe Asn Val Glu Ser Arg Ile 
                565                 570                 575     


Leu Cys Met Leu Tyr Val Pro Val Glu Glu Lys Arg Arg Glu Pro Gly 
            580                 585                 590         


Ala Pro Pro Asp Pro Glu Xaa Pro Ala Val Arg Ala Ser Asp Val Pro 
        595                 600                 605             


Xaa Ile Cys Val Gly Xaa Glu Glu Gly Ser Ile Ser Ile Tyr Lys Ser 
    610                 615                 620                 


Ser Gln Gly Ser Lys Lys Val Arg Leu Gln His Phe Phe Xaa Pro Glu 
625                 630                 635                 640 


Lys Ser Xaa Val Met Ser Leu Ala Cys Xaa Ser Gln Ser Leu Tyr Ala 
                645                 650                 655     


Gly Leu Val Asn Gly Ala Val Ala Ser Tyr Ala Arg Ala Pro Asp Gly 
            660                 665                 670         


Ser Trp Asp Ser Glu Pro Gln Lys Val Ile Lys Leu Gly Val Leu Pro 
        675                 680                 685             


Val Arg Ser Leu Leu Met Met Glu Asp Xaa Leu Trp Ala Ala Ser Gly 
    690                 695                 700                 


Gly Gln Val Phe Ile Ile Ser Val Glu Xaa His Ala Val Glu Gly Gln 
705                 710                 715                 720 


Leu Glu Ala His Gln Glu Glu Gly Met Val Ile Ser His Met Ala Val 
                725                 730                 735     


Ser Gly Val Gly Ile Trp Ile Ala Phe Xaa Ser Gly Ser Xaa Leu Arg 
            740                 745                 750         


Leu Phe His Xaa Glu Xaa Leu Lys His Leu Gln Asp Ile Asn Ile Ala 
        755                 760                 765             


Xaa Pro Val His Asn Met Leu Pro Gly His Gln Arg Leu Ser Val Xaa 
    770                 775                 780                 


Ser Leu Leu Val Cys His Gly Leu Leu Met Val Gly Xaa Ser Leu Gly 
785                 790                 795                 800 


Val Leu Val Ala Leu Pro Val Pro Arg Leu Gln Gly Ile Pro Lys Val 
                805                 810                 815     


Xaa Gly Arg Gly Met Val Ser Tyr His Ala His Asn Ser Pro Val Lys 
            820                 825                 830         


Phe Ile Val Leu Ala Xaa Ala Leu His Glu Lys Asp Lys Asp Lys Ser 
        835                 840                 845             


Arg Asp Ser Leu Ala Pro Gly Pro Glu Pro Gln Asp Glu Asp Gln Lys 
    850                 855                 860                 


Asp Ala Leu Pro Ser Gly Gly Ala Gly Ser Ser Leu Ser Gln Gly Asp 
865                 870                 875                 880 


Pro Asp Ala Ala Ile Trp Leu Gly Asp Ser Leu Gly Ser Met Xaa Gln 
                885                 890                 895     


Lys Ser Asp Leu Ser Ser Ser Ser Gly Ser Leu Ser Leu Ser His Gly 
            900                 905                 910         


Ser Ser Ser Leu Glu His Arg Ser Glu Asp Ser Xaa Ile Tyr Asp Leu 
        915                 920                 925             


Leu Lys Asp Pro Val Ser Leu Arg Ser Lys Ala Arg Arg Ala Lys Lys 
    930                 935                 940                 


Ala Lys Ala Ser Ser Ala Leu Val Val Cys Gly Gly Gln Gly His Arg 
945                 950                 955                 960 


Arg Val His Arg Lys Ala Arg Gln Pro His Gln Glu Glu Leu Ala Pro 
                965                 970                 975     


Xaa Val Met Val Trp Gln Ile Pro Leu Leu Asn Ile 
            980                 985             


<210> 2956
<211> 1306
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1213)..(1213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<400> 2956
Met Asp Gln Arg Glu Pro Leu Pro Pro Ala Pro Ala Glu Asn Glu Met 
1               5                   10                  15      


Lys Tyr Asp Xaa Asn Asn Asn Glu Glu Glu Glu Gly Glu Gln Phe Asp 
            20                  25                  30          


Phe Asp Ser Gly Asp Glu Ile Pro Glu Ala Asp Arg Gln Ala Pro Ser 
        35                  40                  45              


Ala Pro Glu Xaa Gly Gly Ala Gly Ala Ser Glu Ala Pro Ala Pro Xaa 
    50                  55                  60                  


Gly Gly Glu Asp Gly Ala Gly Ala Glu Xaa Xaa Pro Val Ala Glu Pro 
65                  70                  75                  80  


Xaa Lys Leu Val Leu Pro Met Lys Val Asn Pro Tyr Ser Val Ile Asp 
                85                  90                  95      


Ile Xaa Pro Phe Gln Glu Asp Gln Pro Pro Xaa Pro Val Pro Ser Ala 
            100                 105                 110         


Glu Glu Glu Asn Val Gly Leu His Val Pro Cys Gly Tyr Leu Val Pro 
        115                 120                 125             


Val Pro Cys Gly Tyr Ala Val Pro Ser Asn Leu Pro Leu Leu Leu Pro 
    130                 135                 140                 


Ala Tyr Ser Ser Pro Val Ile Ile Cys Ala Xaa Ser Leu Asp Glu Glu 
145                 150                 155                 160 


Ala Glu Xaa Pro Glu Val Xaa Glu Asp Arg Gln Pro Asn Ser Leu Ser 
                165                 170                 175     


Ser Glu Glu Pro Pro Xaa Ser Glu Asp Gln Val Gly Arg Glu Asp Ser 
            180                 185                 190         


Ala Leu Ala Arg Trp Ala Ala Asp Pro Ala Asn Xaa Ala Trp Met Glu 
        195                 200                 205             


Asn Pro Glu Glu Ala Ile Tyr Asp Asp Val Pro Arg Glu Asn Ser Asp 
    210                 215                 220                 


Ser Glu Pro Asp Glu Met Ile Tyr Asp Asp Val Glu Asn Gly Asp Glu 
225                 230                 235                 240 


Gly Gly Asn Ser Ser Leu Glu Tyr Gly Trp Ser Ser Ser Glu Phe Glu 
                245                 250                 255     


Ser Tyr Glu Glu Gln Ser Asp Ser Glu Cys Lys Asn Gly Ile Pro Arg 
            260                 265                 270         


Ser Phe Leu Arg Ser Asn His Lys Lys Gln Met Gln Lys Leu Val Lys 
        275                 280                 285             


Ala Ala Lys Asp Gly Xaa Lys Asp Gly Leu Glu Arg Xaa Arg Ala Ala 
    290                 295                 300                 


Val Lys Arg Gly Arg Ser Phe Ile Arg Xaa Lys Ser Leu Ile Ala Gln 
305                 310                 315                 320 


Asp His Arg Ser Ser Leu Glu Glu Glu Gln Asn Leu Phe Ile Asp Val 
                325                 330                 335     


Asp Cys Lys His Pro Glu Ala Ile Leu Xaa Pro Met Pro Glu Gly Leu 
            340                 345                 350         


Ser Gln Gln Gln Val Val Arg Arg Tyr Ile Leu Gly Ser Val Val Asp 
        355                 360                 365             


Ser Glu Lys Asn Tyr Val Asp Ala Leu Lys Arg Ile Leu Glu Gln Tyr 
    370                 375                 380                 


Glu Lys Pro Leu Ser Glu Met Glu Pro Lys Val Leu Ser Glu Arg Lys 
385                 390                 395                 400 


Leu Lys Xaa Val Phe Tyr Arg Val Lys Glu Ile Leu Gln Cys His Ser 
                405                 410                 415     


Leu Phe Gln Ile Ala Leu Ala Ser Arg Val Ser Glu Trp Asp Ser Val 
            420                 425                 430         


Glu Met Ile Gly Asp Val Phe Val Ala Ser Phe Ser Lys Ser Met Val 
        435                 440                 445             


Leu Asp Ala Tyr Ser Glu Tyr Val Asn Asn Phe Ser Xaa Ala Val Ala 
    450                 455                 460                 


Val Leu Lys Lys Xaa Cys Ala Xaa Lys Pro Ala Phe Leu Glu Phe Leu 
465                 470                 475                 480 


Lys Gln Glu Gln Glu Ala Ser Pro Asp Arg Xaa Xaa Leu Tyr Ser Leu 
                485                 490                 495     


Met Met Lys Pro Ile Gln Arg Phe Pro Gln Phe Ile Leu Leu Leu Gln 
            500                 505                 510         


Asp Met Leu Lys Asn Xaa Ser Lys Gly His Pro Asp Arg Leu Pro Leu 
        515                 520                 525             


Gln Met Ala Leu Xaa Glu Leu Glu Xaa Leu Ala Glu Lys Leu Asn Glu 
    530                 535                 540                 


Arg Lys Arg Asp Ala Asp Gln Arg Cys Glu Val Lys Gln Ile Ala Lys 
545                 550                 555                 560 


Ala Ile Asn Glu Arg Tyr Leu Asn Lys Leu Leu Ser Ser Gly Ser Arg 
                565                 570                 575     


Tyr Leu Ile Arg Ser Asp Asp Met Ile Glu Xaa Val Tyr Asn Asp Arg 
            580                 585                 590         


Gly Glu Ile Val Lys Xaa Lys Glu Arg Arg Val Phe Met Leu Asn Asp 
        595                 600                 605             


Val Leu Met Cys Ala Xaa Val Ser Ser Arg Pro Ser His Asp Ser Arg 
    610                 615                 620                 


Val Met Ser Ser Gln Arg Tyr Leu Leu Lys Trp Ser Val Pro Leu Gly 
625                 630                 635                 640 


His Val Asp Ala Ile Glu Tyr Gly Ser Ser Ala Gly Xaa Gly Glu His 
                645                 650                 655     


Ser Arg His Leu Ala Val His Pro Pro Glu Ser Leu Ala Val Val Ala 
            660                 665                 670         


Asn Ala Lys Pro Asn Lys Val Tyr Met Gly Pro Gly Gln Leu Tyr Gln 
        675                 680                 685             


Asp Leu Gln Asn Leu Leu His Asp Leu Asn Val Ile Gly Gln Ile Xaa 
    690                 695                 700                 


Gln Leu Ile Gly Asn Leu Lys Gly Asn Tyr Gln Asn Leu Asn Gln Ser 
705                 710                 715                 720 


Val Ala His Asp Trp Xaa Ser Gly Leu Gln Arg Leu Ile Leu Lys Lys 
                725                 730                 735     


Glu Asp Glu Ile Arg Ala Ala Asp Cys Cys Arg Ile Gln Leu Gln Leu 
            740                 745                 750         


Pro Gly Lys Gln Asp Lys Ser Gly Arg Pro Xaa Phe Phe Xaa Ala Val 
        755                 760                 765             


Phe Asn Xaa Phe Xaa Pro Ala Ile Lys Glu Ser Trp Val Asn Ser Leu 
    770                 775                 780                 


Gln Met Ala Lys Leu Ala Leu Glu Glu Glu Asn His Met Gly Trp Phe 
785                 790                 795                 800 


Cys Val Glu Asp Asp Gly Asn His Ile Lys Lys Glu Lys His Pro Leu 
                805                 810                 815     


Leu Val Gly His Met Pro Val Met Val Ala Lys Gln Gln Glu Phe Lys 
            820                 825                 830         


Ile Glu Cys Ala Ala Tyr Asn Pro Glu Pro Tyr Leu Asn Asn Glu Ser 
        835                 840                 845             


Gln Pro Asp Ser Phe Ser Xaa Ala His Gly Phe Leu Trp Ile Gly Ser 
    850                 855                 860                 


Cys Xaa His Gln Met Gly Gln Ile Ala Ile Val Ser Phe Gln Asn Ser 
865                 870                 875                 880 


Xaa Pro Lys Val Ile Glu Cys Phe Asn Val Glu Ser Arg Ile Leu Cys 
                885                 890                 895     


Met Leu Tyr Val Pro Val Glu Glu Lys Arg Arg Glu Pro Gly Ala Pro 
            900                 905                 910         


Pro Asp Pro Glu Xaa Pro Ala Val Arg Ala Ser Asp Val Pro Xaa Ile 
        915                 920                 925             


Cys Val Gly Xaa Glu Glu Gly Ser Ile Ser Ile Tyr Lys Ser Ser Gln 
    930                 935                 940                 


Gly Ser Lys Lys Val Arg Leu Gln His Phe Phe Xaa Pro Glu Lys Ser 
945                 950                 955                 960 


Xaa Val Met Ser Leu Ala Cys Xaa Ser Gln Ser Leu Tyr Ala Gly Leu 
                965                 970                 975     


Val Asn Gly Ala Val Ala Ser Tyr Ala Arg Ala Pro Asp Gly Ser Trp 
            980                 985                 990         


Asp Ser Glu Pro Gln Lys Val Ile  Lys Leu Gly Val Leu  Pro Val Arg 
        995                 1000                 1005             


Ser Leu  Leu Met Met Glu Asp  Xaa Leu Trp Ala Ala  Ser Gly Gly 
    1010                 1015                 1020             


Gln Val  Phe Ile Ile Ser Val  Glu Xaa His Ala Val  Glu Gly Gln 
    1025                 1030                 1035             


Leu Glu  Ala His Gln Glu Glu  Gly Met Val Ile Ser  His Met Ala 
    1040                 1045                 1050             


Val Ser  Gly Val Gly Ile Trp  Ile Ala Phe Xaa Ser  Gly Ser Xaa 
    1055                 1060                 1065             


Leu Arg  Leu Phe His Xaa Glu  Xaa Leu Lys His Leu  Gln Asp Ile 
    1070                 1075                 1080             


Asn Ile  Ala Xaa Pro Val His  Asn Met Leu Pro Gly  His Gln Arg 
    1085                 1090                 1095             


Leu Ser  Val Xaa Ser Leu Leu  Val Cys His Gly Leu  Leu Met Val 
    1100                 1105                 1110             


Gly Xaa  Ser Leu Gly Val Leu  Val Ala Leu Pro Val  Pro Arg Leu 
    1115                 1120                 1125             


Gln Gly  Ile Pro Lys Val Xaa  Gly Arg Gly Met Val  Ser Tyr His 
    1130                 1135                 1140             


Ala His  Asn Ser Pro Val Lys  Phe Ile Val Leu Ala  Xaa Ala Leu 
    1145                 1150                 1155             


His Glu  Lys Asp Lys Asp Lys  Ser Arg Asp Ser Leu  Ala Pro Gly 
    1160                 1165                 1170             


Pro Glu  Pro Gln Asp Glu Asp  Gln Lys Asp Ala Leu  Pro Ser Gly 
    1175                 1180                 1185             


Gly Ala  Gly Ser Ser Leu Ser  Gln Gly Asp Pro Asp  Ala Ala Ile 
    1190                 1195                 1200             


Trp Leu  Gly Asp Ser Leu Gly  Ser Met Xaa Gln Lys  Ser Asp Leu 
    1205                 1210                 1215             


Ser Ser  Ser Ser Gly Ser Leu  Ser Leu Ser His Gly  Ser Ser Ser 
    1220                 1225                 1230             


Leu Glu  His Arg Ser Glu Asp  Ser Xaa Ile Tyr Asp  Leu Leu Lys 
    1235                 1240                 1245             


Asp Pro  Val Ser Leu Arg Ser  Lys Ala Arg Arg Ala  Lys Lys Ala 
    1250                 1255                 1260             


Lys Ala  Ser Ser Ala Leu Val  Val Cys Gly Gly Gln  Gly His Arg 
    1265                 1270                 1275             


Arg Val  His Arg Lys Ala Arg  Gln Pro His Gln Glu  Glu Leu Ala 
    1280                 1285                 1290             


Pro Xaa  Val Met Val Trp Gln  Ile Pro Leu Leu Asn  Ile 
    1295                 1300                 1305     


<210> 2957
<211> 1344
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1106)..(1106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1173)..(1173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1280)..(1280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<400> 2957
Met Asp Gln Arg Glu Pro Leu Pro Pro Ala Pro Ala Glu Asn Glu Met 
1               5                   10                  15      


Lys Tyr Asp Xaa Asn Asn Asn Glu Glu Glu Glu Gly Glu Gln Phe Asp 
            20                  25                  30          


Phe Asp Ser Gly Asp Glu Ile Pro Glu Ala Asp Arg Gln Ala Pro Ser 
        35                  40                  45              


Ala Pro Glu Xaa Gly Gly Ala Gly Ala Ser Glu Ala Pro Ala Pro Xaa 
    50                  55                  60                  


Gly Gly Glu Asp Gly Ala Gly Ala Glu Xaa Xaa Pro Val Ala Glu Pro 
65                  70                  75                  80  


Xaa Lys Leu Val Leu Pro Met Lys Val Asn Pro Tyr Ser Val Ile Asp 
                85                  90                  95      


Ile Xaa Pro Phe Gln Glu Asp Gln Pro Pro Xaa Pro Val Pro Ser Ala 
            100                 105                 110         


Glu Glu Glu Asn Val Gly Leu His Val Pro Cys Gly Tyr Leu Val Pro 
        115                 120                 125             


Val Pro Cys Gly Tyr Ala Val Pro Ser Asn Leu Pro Leu Leu Leu Pro 
    130                 135                 140                 


Ala Tyr Ser Ser Pro Val Ile Ile Cys Ala Xaa Ser Leu Asp Glu Glu 
145                 150                 155                 160 


Glu Xaa Pro Glu Val Xaa Glu Asp Arg Gln Pro Asn Ser Leu Ser Ser 
                165                 170                 175     


Glu Glu Pro Pro Xaa Ser Glu Asp Gln Val Gly Arg Glu Asp Ser Ala 
            180                 185                 190         


Leu Ala Arg Trp Ala Ala Asp Pro Ala Asn Xaa Ala Trp Met Glu Asn 
        195                 200                 205             


Pro Glu Glu Ala Ile Tyr Asp Asp Val Pro Arg Glu Asn Ser Asp Ser 
    210                 215                 220                 


Glu Pro Asp Glu Met Ile Tyr Asp Asp Val Glu Asn Gly Asp Glu Gly 
225                 230                 235                 240 


Gly Asn Ser Ser Leu Glu Tyr Gly Trp Ser Ser Ser Glu Phe Glu Ser 
                245                 250                 255     


Tyr Glu Glu Gln Ser Asp Ser Glu Cys Lys Asn Gly Ile Pro Arg Ser 
            260                 265                 270         


Phe Leu Arg Ser Asn His Lys Lys Gln Leu Ser His Asp Leu Xaa Arg 
        275                 280                 285             


Leu Lys Glu His Tyr Glu Lys Lys Met Arg Asp Leu Met Ala Ser Xaa 
    290                 295                 300                 


Val Gly Val Val Glu Ile Gln Gln Leu Arg Gln Lys His Glu Leu Lys 
305                 310                 315                 320 


Met Gln Lys Leu Val Lys Ala Ala Lys Asp Gly Xaa Lys Asp Gly Leu 
                325                 330                 335     


Glu Arg Xaa Arg Ala Ala Val Lys Arg Gly Arg Ser Phe Ile Arg Xaa 
            340                 345                 350         


Lys Ser Leu Ile Ala Gln Asp His Arg Ser Ser Leu Glu Glu Glu Gln 
        355                 360                 365             


Asn Leu Phe Ile Asp Val Asp Cys Lys His Pro Glu Ala Ile Leu Xaa 
    370                 375                 380                 


Pro Met Pro Glu Gly Leu Ser Gln Gln Gln Val Val Arg Arg Tyr Ile 
385                 390                 395                 400 


Leu Gly Ser Val Val Asp Ser Glu Lys Asn Tyr Val Asp Ala Leu Lys 
                405                 410                 415     


Arg Ile Leu Glu Gln Tyr Glu Lys Pro Leu Ser Glu Met Glu Pro Lys 
            420                 425                 430         


Val Leu Ser Glu Arg Lys Leu Lys Xaa Val Phe Tyr Arg Val Lys Glu 
        435                 440                 445             


Ile Leu Gln Cys His Ser Leu Phe Gln Ile Ala Leu Ala Ser Arg Val 
    450                 455                 460                 


Ser Glu Trp Asp Ser Val Glu Met Ile Gly Asp Val Phe Val Ala Ser 
465                 470                 475                 480 


Phe Ser Lys Ser Met Val Leu Asp Ala Tyr Ser Glu Tyr Val Asn Asn 
                485                 490                 495     


Phe Ser Xaa Ala Val Ala Val Leu Lys Lys Xaa Cys Ala Xaa Lys Pro 
            500                 505                 510         


Ala Phe Leu Glu Phe Leu Lys Gln Glu Gln Glu Ala Ser Pro Asp Arg 
        515                 520                 525             


Xaa Xaa Leu Tyr Ser Leu Met Met Lys Pro Ile Gln Arg Phe Pro Gln 
    530                 535                 540                 


Phe Ile Leu Leu Leu Gln Asp Met Leu Lys Asn Xaa Ser Lys Gly His 
545                 550                 555                 560 


Pro Asp Arg Leu Pro Leu Gln Met Ala Leu Xaa Glu Leu Glu Xaa Leu 
                565                 570                 575     


Ala Glu Lys Leu Asn Glu Arg Lys Arg Asp Ala Asp Gln Arg Cys Glu 
            580                 585                 590         


Val Lys Gln Ile Ala Lys Ala Ile Asn Glu Arg Tyr Leu Asn Lys Leu 
        595                 600                 605             


Leu Ser Ser Gly Ser Arg Tyr Leu Ile Arg Ser Asp Asp Met Ile Glu 
    610                 615                 620                 


Xaa Val Tyr Asn Asp Arg Gly Glu Ile Val Lys Xaa Lys Glu Arg Arg 
625                 630                 635                 640 


Val Phe Met Leu Asn Asp Val Leu Met Cys Ala Xaa Val Ser Ser Arg 
                645                 650                 655     


Pro Ser His Asp Ser Arg Val Met Ser Ser Gln Arg Tyr Leu Leu Lys 
            660                 665                 670         


Trp Ser Val Pro Leu Gly His Val Asp Ala Ile Glu Tyr Gly Ser Ser 
        675                 680                 685             


Ala Gly Xaa Gly Glu His Ser Arg His Leu Ala Val His Pro Pro Glu 
    690                 695                 700                 


Ser Leu Ala Val Val Ala Asn Ala Lys Pro Asn Lys Val Tyr Met Gly 
705                 710                 715                 720 


Pro Gly Gln Leu Tyr Gln Asp Leu Gln Asn Leu Leu His Asp Leu Asn 
                725                 730                 735     


Val Ile Gly Gln Ile Xaa Gln Leu Ile Gly Asn Leu Lys Gly Asn Tyr 
            740                 745                 750         


Gln Asn Leu Asn Gln Ser Val Ala His Asp Trp Xaa Ser Gly Leu Gln 
        755                 760                 765             


Arg Leu Ile Leu Lys Lys Glu Asp Glu Ile Arg Ala Ala Asp Cys Cys 
    770                 775                 780                 


Arg Ile Gln Leu Gln Leu Pro Gly Lys Gln Asp Lys Ser Gly Arg Pro 
785                 790                 795                 800 


Xaa Phe Phe Xaa Ala Val Phe Asn Xaa Phe Xaa Pro Ala Ile Lys Glu 
                805                 810                 815     


Ser Trp Val Asn Ser Leu Gln Met Ala Lys Leu Ala Leu Glu Glu Glu 
            820                 825                 830         


Asn His Met Gly Trp Phe Cys Val Glu Asp Asp Gly Asn His Ile Lys 
        835                 840                 845             


Lys Glu Lys His Pro Leu Leu Val Gly His Met Pro Val Met Val Ala 
    850                 855                 860                 


Lys Gln Gln Glu Phe Lys Ile Glu Cys Ala Ala Tyr Asn Pro Glu Pro 
865                 870                 875                 880 


Tyr Leu Asn Asn Glu Ser Gln Pro Asp Ser Phe Ser Xaa Ala His Gly 
                885                 890                 895     


Phe Leu Trp Ile Gly Ser Cys Xaa His Gln Met Gly Gln Ile Ala Ile 
            900                 905                 910         


Val Ser Phe Gln Asn Ser Xaa Pro Lys Val Ile Glu Cys Phe Asn Val 
        915                 920                 925             


Glu Ser Arg Ile Leu Cys Met Leu Tyr Val Pro Val Glu Glu Lys Arg 
    930                 935                 940                 


Arg Glu Pro Gly Ala Pro Pro Asp Pro Glu Xaa Pro Ala Val Arg Ala 
945                 950                 955                 960 


Ser Asp Val Pro Xaa Ile Cys Val Gly Xaa Glu Glu Gly Ser Ile Ser 
                965                 970                 975     


Ile Tyr Lys Ser Ser Gln Gly Ser Lys Lys Val Arg Leu Gln His Phe 
            980                 985                 990         


Phe Xaa Pro Glu Lys Ser Xaa Val  Met Ser Leu Ala Cys  Xaa Ser Gln 
        995                 1000                 1005             


Ser Leu  Tyr Ala Gly Leu Val  Asn Gly Ala Val Ala  Ser Tyr Ala 
    1010                 1015                 1020             


Arg Ala  Pro Asp Gly Ser Trp  Asp Ser Glu Pro Gln  Lys Val Ile 
    1025                 1030                 1035             


Lys Leu  Gly Val Leu Pro Val  Arg Ser Leu Leu Met  Met Glu Asp 
    1040                 1045                 1050             


Xaa Leu  Trp Ala Ala Ser Gly  Gly Gln Val Phe Ile  Ile Ser Val 
    1055                 1060                 1065             


Glu Xaa  His Ala Val Glu Gly  Gln Leu Glu Ala His  Gln Glu Glu 
    1070                 1075                 1080             


Gly Met  Val Ile Ser His Met  Ala Val Ser Gly Val  Gly Ile Trp 
    1085                 1090                 1095             


Ile Ala  Phe Xaa Ser Gly Ser  Xaa Leu Arg Leu Phe  His Xaa Glu 
    1100                 1105                 1110             


Xaa Leu  Lys His Leu Gln Asp  Ile Asn Ile Ala Xaa  Pro Val His 
    1115                 1120                 1125             


Asn Met  Leu Pro Gly His Gln  Arg Leu Ser Val Xaa  Ser Leu Leu 
    1130                 1135                 1140             


Val Cys  His Gly Leu Leu Met  Val Gly Xaa Ser Leu  Gly Val Leu 
    1145                 1150                 1155             


Val Ala  Leu Pro Val Pro Arg  Leu Gln Gly Ile Pro  Lys Val Xaa 
    1160                 1165                 1170             


Gly Arg  Gly Met Val Ser Tyr  His Ala His Asn Ser  Pro Val Lys 
    1175                 1180                 1185             


Phe Ile  Val Leu Ala Xaa Ala  Leu His Glu Lys Asp  Lys Asp Lys 
    1190                 1195                 1200             


Ser Arg  Asp Ser Leu Ala Pro  Gly Pro Glu Pro Gln  Asp Glu Asp 
    1205                 1210                 1215             


Gln Lys  Asp Ala Leu Pro Ser  Gly Gly Ala Gly Ser  Ser Leu Ser 
    1220                 1225                 1230             


Gln Gly  Asp Pro Asp Ala Ala  Ile Trp Leu Gly Asp  Ser Leu Gly 
    1235                 1240                 1245             


Ser Met  Xaa Gln Lys Ser Asp  Leu Ser Ser Ser Ser  Gly Ser Leu 
    1250                 1255                 1260             


Ser Leu  Ser His Gly Ser Ser  Ser Leu Glu His Arg  Ser Glu Asp 
    1265                 1270                 1275             


Ser Xaa  Ile Tyr Asp Leu Leu  Lys Asp Pro Val Ser  Leu Arg Ser 
    1280                 1285                 1290             


Lys Ala  Arg Arg Ala Lys Lys  Ala Lys Ala Ser Ser  Ala Leu Val 
    1295                 1300                 1305             


Val Cys  Gly Gly Gln Gly His  Arg Arg Val His Arg  Lys Ala Arg 
    1310                 1315                 1320             


Gln Pro  His Gln Glu Glu Leu  Ala Pro Xaa Val Met  Val Trp Gln 
    1325                 1330                 1335             


Ile Pro  Leu Leu Asn Ile 
    1340                 


<210> 2958
<211> 380
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<400> 2958
Met Glu Asn Pro Glu Glu Ala Ile Tyr Asp Asp Val Pro Arg Glu Asn 
1               5                   10                  15      


Ser Asp Ser Glu Pro Asp Glu Met Ile Tyr Asp Asp Val Glu Asn Gly 
            20                  25                  30          


Asp Glu Gly Gly Asn Ser Ser Leu Glu Tyr Gly Trp Ser Ser Ser Glu 
        35                  40                  45              


Phe Glu Ser Tyr Glu Glu Gln Ser Asp Ser Glu Cys Lys Asn Gly Ile 
    50                  55                  60                  


Pro Arg Ser Phe Leu Arg Ser Asn His Lys Lys Gln Met Gln Lys Leu 
65                  70                  75                  80  


Val Lys Ala Ala Lys Asp Gly Xaa Lys Asp Gly Leu Glu Arg Xaa Arg 
                85                  90                  95      


Ala Ala Val Lys Arg Gly Arg Ser Phe Ile Arg Xaa Lys Ser Leu Ile 
            100                 105                 110         


Ala Gln Asp His Arg Ser Ser Leu Glu Glu Glu Gln Asn Leu Phe Ile 
        115                 120                 125             


Asp Val Asp Cys Lys His Pro Glu Ala Ile Leu Xaa Pro Met Pro Glu 
    130                 135                 140                 


Gly Leu Ser Gln Gln Gln Val Val Arg Arg Tyr Ile Leu Gly Ser Val 
145                 150                 155                 160 


Val Asp Ser Glu Lys Asn Tyr Val Asp Ala Leu Lys Arg Ile Leu Glu 
                165                 170                 175     


Gln Tyr Glu Lys Pro Leu Ser Glu Met Glu Pro Lys Val Leu Ser Glu 
            180                 185                 190         


Arg Lys Leu Lys Xaa Val Phe Tyr Arg Val Lys Glu Ile Leu Gln Cys 
        195                 200                 205             


His Ser Leu Phe Gln Ile Ala Leu Ala Ser Arg Val Ser Glu Trp Asp 
    210                 215                 220                 


Ser Val Glu Met Ile Gly Asp Val Phe Val Ala Ser Phe Ser Lys Ser 
225                 230                 235                 240 


Met Val Leu Asp Ala Tyr Ser Glu Tyr Val Asn Asn Phe Ser Xaa Ala 
                245                 250                 255     


Val Ala Val Leu Lys Lys Xaa Cys Ala Xaa Lys Pro Ala Phe Leu Glu 
            260                 265                 270         


Phe Leu Lys Gln Glu Gln Glu Ala Ser Pro Asp Arg Xaa Xaa Leu Tyr 
        275                 280                 285             


Ser Leu Met Met Lys Pro Ile Gln Arg Phe Pro Gln Phe Ile Leu Leu 
    290                 295                 300                 


Leu Gln Asp Met Leu Lys Asn Xaa Ser Lys Gly His Pro Asp Arg Leu 
305                 310                 315                 320 


Pro Leu Gln Met Ala Leu Xaa Glu Leu Glu Xaa Leu Ala Glu Lys Leu 
                325                 330                 335     


Asn Glu Arg Lys Arg Asp Ala Asp Gln Arg Cys Glu Val Lys Gln Ile 
            340                 345                 350         


Ala Lys Ala Ile Asn Glu Arg Tyr Leu Asn Lys Val Glu Arg Gly Phe 
        355                 360                 365             


Leu Gln Leu Tyr Ser Lys Ile Ile Phe Ala Leu Cys 
    370                 375                 380 


<210> 2959
<211> 1368
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1138)..(1138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1197)..(1197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1218)..(1218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1304)..(1304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1357)..(1357)
<223> Selenocysteine

<400> 2959
Met Arg Pro Pro Gly Phe Leu Ser Arg Ala Pro Ser Leu Asn Arg Ala 
1               5                   10                  15      


Glu Arg Gly Ile Trp Ser Cys Ser Met Asp Gln Arg Glu Pro Leu Pro 
            20                  25                  30          


Pro Ala Pro Ala Glu Asn Glu Met Lys Tyr Asp Xaa Asn Asn Asn Glu 
        35                  40                  45              


Glu Glu Glu Gly Glu Gln Phe Asp Phe Asp Ser Gly Asp Glu Ile Pro 
    50                  55                  60                  


Glu Ala Asp Arg Gln Ala Pro Ser Ala Pro Glu Xaa Gly Gly Ala Gly 
65                  70                  75                  80  


Ala Ser Glu Ala Pro Ala Pro Xaa Gly Gly Glu Asp Gly Ala Gly Ala 
                85                  90                  95      


Glu Xaa Xaa Pro Val Ala Glu Pro Xaa Lys Leu Val Leu Pro Met Lys 
            100                 105                 110         


Val Asn Pro Tyr Ser Val Ile Asp Ile Xaa Pro Phe Gln Glu Asp Gln 
        115                 120                 125             


Pro Pro Xaa Pro Val Pro Ser Ala Glu Glu Glu Asn Val Gly Leu His 
    130                 135                 140                 


Val Pro Cys Gly Tyr Leu Val Pro Val Pro Cys Gly Tyr Ala Val Pro 
145                 150                 155                 160 


Ser Asn Leu Pro Leu Leu Leu Pro Ala Tyr Ser Ser Pro Val Ile Ile 
                165                 170                 175     


Cys Ala Xaa Ser Leu Asp Glu Glu Ala Glu Xaa Pro Glu Val Xaa Glu 
            180                 185                 190         


Asp Arg Gln Pro Asn Ser Leu Ser Ser Glu Glu Pro Pro Xaa Ser Glu 
        195                 200                 205             


Asp Gln Val Gly Arg Glu Asp Ser Ala Leu Ala Arg Trp Ala Ala Asp 
    210                 215                 220                 


Pro Ala Asn Xaa Ala Trp Met Glu Asn Pro Glu Glu Ala Ile Tyr Asp 
225                 230                 235                 240 


Asp Val Pro Arg Glu Asn Ser Asp Ser Glu Pro Asp Glu Met Ile Tyr 
                245                 250                 255     


Asp Asp Val Glu Asn Gly Asp Glu Gly Gly Asn Ser Ser Leu Glu Tyr 
            260                 265                 270         


Gly Trp Ser Ser Ser Glu Phe Glu Ser Tyr Glu Glu Gln Ser Asp Ser 
        275                 280                 285             


Glu Cys Lys Asn Gly Ile Pro Arg Ser Phe Leu Arg Ser Asn His Lys 
    290                 295                 300                 


Lys Gln Leu Ser His Asp Leu Xaa Arg Leu Lys Glu His Tyr Glu Lys 
305                 310                 315                 320 


Lys Met Arg Asp Leu Met Ala Ser Xaa Val Gly Val Val Glu Ile Gln 
                325                 330                 335     


Gln Leu Arg Gln Lys His Glu Leu Lys Met Gln Lys Leu Val Lys Ala 
            340                 345                 350         


Ala Lys Asp Gly Xaa Lys Asp Gly Leu Glu Arg Xaa Arg Ala Ala Val 
        355                 360                 365             


Lys Arg Gly Arg Ser Phe Ile Arg Xaa Lys Ser Leu Ile Ala Gln Asp 
    370                 375                 380                 


His Arg Ser Ser Leu Glu Glu Glu Gln Asn Leu Phe Ile Asp Val Asp 
385                 390                 395                 400 


Cys Lys His Pro Glu Ala Ile Leu Xaa Pro Met Pro Glu Gly Leu Ser 
                405                 410                 415     


Gln Gln Gln Val Val Arg Arg Tyr Ile Leu Gly Ser Val Val Asp Ser 
            420                 425                 430         


Glu Lys Asn Tyr Val Asp Ala Leu Lys Arg Ile Leu Glu Gln Tyr Glu 
        435                 440                 445             


Lys Pro Leu Ser Glu Met Glu Pro Lys Val Leu Ser Glu Arg Lys Leu 
    450                 455                 460                 


Lys Xaa Val Phe Tyr Arg Val Lys Glu Ile Leu Gln Cys His Ser Leu 
465                 470                 475                 480 


Phe Gln Ile Ala Leu Ala Ser Arg Val Ser Glu Trp Asp Ser Val Glu 
                485                 490                 495     


Met Ile Gly Asp Val Phe Val Ala Ser Phe Ser Lys Ser Met Val Leu 
            500                 505                 510         


Asp Ala Tyr Ser Glu Tyr Val Asn Asn Phe Ser Xaa Ala Val Ala Val 
        515                 520                 525             


Leu Lys Lys Xaa Cys Ala Xaa Lys Pro Ala Phe Leu Glu Phe Leu Lys 
    530                 535                 540                 


Glu Gln Glu Ala Ser Pro Asp Arg Xaa Xaa Leu Tyr Ser Leu Met Met 
545                 550                 555                 560 


Lys Pro Ile Gln Arg Phe Pro Gln Phe Ile Leu Leu Leu Gln Asp Met 
                565                 570                 575     


Leu Lys Asn Xaa Ser Lys Gly His Pro Asp Arg Leu Pro Leu Gln Met 
            580                 585                 590         


Ala Leu Xaa Glu Leu Glu Xaa Leu Ala Glu Lys Leu Asn Glu Arg Lys 
        595                 600                 605             


Arg Asp Ala Asp Gln Arg Cys Glu Val Lys Gln Ile Ala Lys Ala Ile 
    610                 615                 620                 


Asn Glu Arg Tyr Leu Asn Lys Leu Leu Ser Ser Gly Ser Arg Tyr Leu 
625                 630                 635                 640 


Ile Arg Ser Asp Asp Met Ile Glu Xaa Val Tyr Asn Asp Arg Gly Glu 
                645                 650                 655     


Ile Val Lys Xaa Lys Glu Arg Arg Val Phe Met Leu Asn Asp Val Leu 
            660                 665                 670         


Met Cys Ala Xaa Val Ser Ser Arg Pro Ser His Asp Ser Arg Val Met 
        675                 680                 685             


Ser Ser Gln Arg Tyr Leu Leu Lys Trp Ser Val Pro Leu Gly His Val 
    690                 695                 700                 


Asp Ala Ile Glu Tyr Gly Ser Ser Ala Gly Xaa Gly Glu His Ser Arg 
705                 710                 715                 720 


His Leu Ala Val His Pro Pro Glu Ser Leu Ala Val Val Ala Asn Ala 
                725                 730                 735     


Lys Pro Asn Lys Val Tyr Met Gly Pro Gly Gln Leu Tyr Gln Asp Leu 
            740                 745                 750         


Gln Asn Leu Leu His Asp Leu Asn Val Ile Gly Gln Ile Xaa Gln Leu 
        755                 760                 765             


Ile Gly Asn Leu Lys Gly Asn Tyr Gln Asn Leu Asn Gln Ser Val Ala 
    770                 775                 780                 


His Asp Trp Xaa Ser Gly Leu Gln Arg Leu Ile Leu Lys Lys Glu Asp 
785                 790                 795                 800 


Glu Ile Arg Ala Ala Asp Cys Cys Arg Ile Gln Leu Gln Leu Pro Gly 
                805                 810                 815     


Lys Gln Asp Lys Ser Gly Arg Pro Xaa Phe Phe Xaa Ala Val Phe Asn 
            820                 825                 830         


Xaa Phe Xaa Pro Ala Ile Lys Glu Ser Trp Val Asn Ser Leu Gln Met 
        835                 840                 845             


Ala Lys Leu Ala Leu Glu Glu Glu Asn His Met Gly Trp Phe Cys Val 
    850                 855                 860                 


Glu Asp Asp Gly Asn His Ile Lys Lys Glu Lys His Pro Leu Leu Val 
865                 870                 875                 880 


Gly His Met Pro Val Met Val Ala Lys Gln Gln Glu Phe Lys Ile Glu 
                885                 890                 895     


Cys Ala Ala Tyr Asn Pro Glu Pro Tyr Leu Asn Asn Glu Ser Gln Pro 
            900                 905                 910         


Asp Ser Phe Ser Xaa Ala His Gly Phe Leu Trp Ile Gly Ser Cys Xaa 
        915                 920                 925             


His Gln Met Gly Gln Ile Ala Ile Val Ser Phe Gln Asn Ser Xaa Pro 
    930                 935                 940                 


Lys Val Ile Glu Cys Phe Asn Val Glu Ser Arg Ile Leu Cys Met Leu 
945                 950                 955                 960 


Tyr Val Pro Val Glu Glu Lys Arg Arg Glu Pro Gly Ala Pro Pro Asp 
                965                 970                 975     


Pro Glu Xaa Pro Ala Val Arg Ala Ser Asp Val Pro Xaa Ile Cys Val 
            980                 985                 990         


Gly Xaa Glu Glu Gly Ser Ile Ser  Ile Tyr Lys Ser Ser  Gln Gly Ser 
        995                 1000                 1005             


Lys Lys  Val Arg Leu Gln His  Phe Phe Xaa Pro Glu  Lys Ser Xaa 
    1010                 1015                 1020             


Val Met  Ser Leu Ala Cys Xaa  Ser Gln Ser Leu Tyr  Ala Gly Leu 
    1025                 1030                 1035             


Val Asn  Gly Ala Val Ala Ser  Tyr Ala Arg Ala Pro  Asp Gly Ser 
    1040                 1045                 1050             


Trp Asp  Ser Glu Pro Gln Lys  Val Ile Lys Leu Gly  Val Leu Pro 
    1055                 1060                 1065             


Val Arg  Ser Leu Leu Met Met  Glu Asp Xaa Leu Trp  Ala Ala Ser 
    1070                 1075                 1080             


Gly Gly  Gln Val Phe Ile Ile  Ser Val Glu Xaa His  Ala Val Glu 
    1085                 1090                 1095             


Gly Gln  Leu Glu Ala His Gln  Glu Glu Gly Met Val  Ile Ser His 
    1100                 1105                 1110             


Met Ala  Val Ser Gly Val Gly  Ile Trp Ile Ala Phe  Xaa Ser Gly 
    1115                 1120                 1125             


Ser Xaa  Leu Arg Leu Phe His  Xaa Glu Xaa Leu Lys  His Leu Gln 
    1130                 1135                 1140             


Asp Ile  Asn Ile Ala Xaa Pro  Val His Asn Met Leu  Pro Gly His 
    1145                 1150                 1155             


Gln Arg  Leu Ser Val Xaa Ser  Leu Leu Val Cys His  Gly Leu Leu 
    1160                 1165                 1170             


Met Val  Gly Xaa Ser Leu Gly  Val Leu Val Ala Leu  Pro Val Pro 
    1175                 1180                 1185             


Arg Leu  Gln Gly Ile Pro Lys  Val Xaa Gly Arg Gly  Met Val Ser 
    1190                 1195                 1200             


Tyr His  Ala His Asn Ser Pro  Val Lys Phe Ile Val  Leu Ala Xaa 
    1205                 1210                 1215             


Ala Leu  His Glu Lys Asp Lys  Asp Lys Ser Arg Asp  Ser Leu Ala 
    1220                 1225                 1230             


Pro Gly  Pro Glu Pro Gln Asp  Glu Asp Gln Lys Asp  Ala Leu Pro 
    1235                 1240                 1245             


Ser Gly  Gly Ala Gly Ser Ser  Leu Ser Gln Gly Asp  Pro Asp Ala 
    1250                 1255                 1260             


Ala Ile  Trp Leu Gly Asp Ser  Leu Gly Ser Met Xaa  Gln Lys Ser 
    1265                 1270                 1275             


Asp Leu  Ser Ser Ser Ser Gly  Ser Leu Ser Leu Ser  His Gly Ser 
    1280                 1285                 1290             


Ser Ser  Leu Glu His Arg Ser  Glu Asp Ser Xaa Ile  Tyr Asp Leu 
    1295                 1300                 1305             


Leu Lys  Asp Pro Val Ser Leu  Arg Ser Lys Ala Arg  Arg Ala Lys 
    1310                 1315                 1320             


Lys Ala  Lys Ala Ser Ser Ala  Leu Val Val Cys Gly  Gly Gln Gly 
    1325                 1330                 1335             


His Arg  Arg Val His Arg Lys  Ala Arg Gln Pro His  Gln Glu Glu 
    1340                 1345                 1350             


Leu Ala  Pro Xaa Val Met Val  Trp Gln Ile Pro Leu  Leu Asn Ile 
    1355                 1360                 1365             


<210> 2960
<211> 1369
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1131)..(1131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1276)..(1276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<400> 2960
Met Arg Pro Pro Gly Phe Leu Ser Arg Ala Pro Ser Leu Asn Arg Ala 
1               5                   10                  15      


Glu Arg Gly Ile Trp Ser Cys Ser Met Asp Gln Arg Glu Pro Leu Pro 
            20                  25                  30          


Pro Ala Pro Ala Glu Asn Glu Met Lys Tyr Asp Xaa Asn Asn Asn Glu 
        35                  40                  45              


Glu Glu Glu Gly Glu Gln Phe Asp Phe Asp Ser Gly Asp Glu Ile Pro 
    50                  55                  60                  


Glu Ala Asp Arg Gln Ala Pro Ser Ala Pro Glu Xaa Gly Gly Ala Gly 
65                  70                  75                  80  


Ala Ser Glu Ala Pro Ala Pro Xaa Gly Gly Glu Asp Gly Ala Gly Ala 
                85                  90                  95      


Glu Xaa Xaa Pro Val Ala Glu Pro Xaa Lys Leu Val Leu Pro Met Lys 
            100                 105                 110         


Val Asn Pro Tyr Ser Val Ile Asp Ile Xaa Pro Phe Gln Glu Asp Gln 
        115                 120                 125             


Pro Pro Xaa Pro Val Pro Ser Ala Glu Glu Glu Asn Val Gly Leu His 
    130                 135                 140                 


Val Pro Cys Gly Tyr Leu Val Pro Val Pro Cys Gly Tyr Ala Val Pro 
145                 150                 155                 160 


Ser Asn Leu Pro Leu Leu Leu Pro Ala Tyr Ser Ser Pro Val Ile Ile 
                165                 170                 175     


Cys Ala Xaa Ser Leu Asp Glu Glu Ala Glu Xaa Pro Glu Val Xaa Glu 
            180                 185                 190         


Asp Arg Gln Pro Asn Ser Leu Ser Ser Glu Glu Pro Pro Xaa Ser Glu 
        195                 200                 205             


Asp Gln Val Gly Arg Glu Asp Ser Ala Leu Ala Arg Trp Ala Ala Asp 
    210                 215                 220                 


Pro Ala Asn Xaa Ala Trp Met Glu Asn Pro Glu Glu Ala Ile Tyr Asp 
225                 230                 235                 240 


Asp Val Pro Arg Glu Asn Ser Asp Ser Glu Pro Asp Glu Met Ile Tyr 
                245                 250                 255     


Asp Asp Val Glu Asn Gly Asp Glu Gly Gly Asn Ser Ser Leu Glu Tyr 
            260                 265                 270         


Gly Trp Ser Ser Ser Glu Phe Glu Ser Tyr Glu Glu Gln Ser Asp Ser 
        275                 280                 285             


Glu Cys Lys Asn Gly Ile Pro Arg Ser Phe Leu Arg Ser Asn His Lys 
    290                 295                 300                 


Lys Gln Leu Ser His Asp Leu Xaa Arg Leu Lys Glu His Tyr Glu Lys 
305                 310                 315                 320 


Lys Met Arg Asp Leu Met Ala Ser Xaa Val Gly Val Val Glu Ile Gln 
                325                 330                 335     


Gln Leu Arg Gln Lys His Glu Leu Lys Met Gln Lys Leu Val Lys Ala 
            340                 345                 350         


Ala Lys Asp Gly Xaa Lys Asp Gly Leu Glu Arg Xaa Arg Ala Ala Val 
        355                 360                 365             


Lys Arg Gly Arg Ser Phe Ile Arg Xaa Lys Ser Leu Ile Ala Gln Asp 
    370                 375                 380                 


His Arg Ser Ser Leu Glu Glu Glu Gln Asn Leu Phe Ile Asp Val Asp 
385                 390                 395                 400 


Cys Lys His Pro Glu Ala Ile Leu Xaa Pro Met Pro Glu Gly Leu Ser 
                405                 410                 415     


Gln Gln Gln Val Val Arg Arg Tyr Ile Leu Gly Ser Val Val Asp Ser 
            420                 425                 430         


Glu Lys Asn Tyr Val Asp Ala Leu Lys Arg Ile Leu Glu Gln Tyr Glu 
        435                 440                 445             


Lys Pro Leu Ser Glu Met Glu Pro Lys Val Leu Ser Glu Arg Lys Leu 
    450                 455                 460                 


Lys Xaa Val Phe Tyr Arg Val Lys Glu Ile Leu Gln Cys His Ser Leu 
465                 470                 475                 480 


Phe Gln Ile Ala Leu Ala Ser Arg Val Ser Glu Trp Asp Ser Val Glu 
                485                 490                 495     


Met Ile Gly Asp Val Phe Val Ala Ser Phe Ser Lys Ser Met Val Leu 
            500                 505                 510         


Asp Ala Tyr Ser Glu Tyr Val Asn Asn Phe Ser Xaa Ala Val Ala Val 
        515                 520                 525             


Leu Lys Lys Xaa Cys Ala Xaa Lys Pro Ala Phe Leu Glu Phe Leu Lys 
    530                 535                 540                 


Gln Glu Gln Glu Ala Ser Pro Asp Arg Xaa Xaa Leu Tyr Ser Leu Met 
545                 550                 555                 560 


Met Lys Pro Ile Gln Arg Phe Pro Gln Phe Ile Leu Leu Leu Gln Asp 
                565                 570                 575     


Met Leu Lys Asn Xaa Ser Lys Gly His Pro Asp Arg Leu Pro Leu Gln 
            580                 585                 590         


Met Ala Leu Xaa Glu Leu Glu Xaa Leu Ala Glu Lys Leu Asn Glu Arg 
        595                 600                 605             


Lys Arg Asp Ala Asp Gln Arg Cys Glu Val Lys Gln Ile Ala Lys Ala 
    610                 615                 620                 


Ile Asn Glu Arg Tyr Leu Asn Lys Leu Leu Ser Ser Gly Ser Arg Tyr 
625                 630                 635                 640 


Leu Ile Arg Ser Asp Asp Met Ile Glu Xaa Val Tyr Asn Asp Arg Gly 
                645                 650                 655     


Glu Ile Val Lys Xaa Lys Glu Arg Arg Val Phe Met Leu Asn Asp Val 
            660                 665                 670         


Leu Met Cys Ala Xaa Val Ser Ser Arg Pro Ser His Asp Ser Arg Val 
        675                 680                 685             


Met Ser Ser Gln Arg Tyr Leu Leu Lys Trp Ser Val Pro Leu Gly His 
    690                 695                 700                 


Val Asp Ala Ile Glu Tyr Gly Ser Ser Ala Gly Xaa Gly Glu His Ser 
705                 710                 715                 720 


Arg His Leu Ala Val His Pro Pro Glu Ser Leu Ala Val Val Ala Asn 
                725                 730                 735     


Ala Lys Pro Asn Lys Val Tyr Met Gly Pro Gly Gln Leu Tyr Gln Asp 
            740                 745                 750         


Leu Gln Asn Leu Leu His Asp Leu Asn Val Ile Gly Gln Ile Xaa Gln 
        755                 760                 765             


Leu Ile Gly Asn Leu Lys Gly Asn Tyr Gln Asn Leu Asn Gln Ser Val 
    770                 775                 780                 


Ala His Asp Trp Xaa Ser Gly Leu Gln Arg Leu Ile Leu Lys Lys Glu 
785                 790                 795                 800 


Asp Glu Ile Arg Ala Ala Asp Cys Cys Arg Ile Gln Leu Gln Leu Pro 
                805                 810                 815     


Gly Lys Gln Asp Lys Ser Gly Arg Pro Xaa Phe Phe Xaa Ala Val Phe 
            820                 825                 830         


Asn Xaa Phe Xaa Pro Ala Ile Lys Glu Ser Trp Val Asn Ser Leu Gln 
        835                 840                 845             


Met Ala Lys Leu Ala Leu Glu Glu Glu Asn His Met Gly Trp Phe Cys 
    850                 855                 860                 


Val Glu Asp Asp Gly Asn His Ile Lys Lys Glu Lys His Pro Leu Leu 
865                 870                 875                 880 


Val Gly His Met Pro Val Met Val Ala Lys Gln Gln Glu Phe Lys Ile 
                885                 890                 895     


Glu Cys Ala Ala Tyr Asn Pro Glu Pro Tyr Leu Asn Asn Glu Ser Gln 
            900                 905                 910         


Pro Asp Ser Phe Ser Xaa Ala His Gly Phe Leu Trp Ile Gly Ser Cys 
        915                 920                 925             


Xaa His Gln Met Gly Gln Ile Ala Ile Val Ser Phe Gln Asn Ser Xaa 
    930                 935                 940                 


Pro Lys Val Ile Glu Cys Phe Asn Val Glu Ser Arg Ile Leu Cys Met 
945                 950                 955                 960 


Leu Tyr Val Pro Val Glu Glu Lys Arg Arg Glu Pro Gly Ala Pro Pro 
                965                 970                 975     


Asp Pro Glu Xaa Pro Ala Val Arg Ala Ser Asp Val Pro Xaa Ile Cys 
            980                 985                 990         


Val Gly Xaa Glu Glu Gly Ser Ile  Ser Ile Tyr Lys Ser  Ser Gln Gly 
        995                 1000                 1005             


Ser Lys  Lys Val Arg Leu Gln  His Phe Phe Xaa Pro  Glu Lys Ser 
    1010                 1015                 1020             


Xaa Val  Met Ser Leu Ala Cys  Xaa Ser Gln Ser Leu  Tyr Ala Gly 
    1025                 1030                 1035             


Leu Val  Asn Gly Ala Val Ala  Ser Tyr Ala Arg Ala  Pro Asp Gly 
    1040                 1045                 1050             


Ser Trp  Asp Ser Glu Pro Gln  Lys Val Ile Lys Leu  Gly Val Leu 
    1055                 1060                 1065             


Pro Val  Arg Ser Leu Leu Met  Met Glu Asp Xaa Leu  Trp Ala Ala 
    1070                 1075                 1080             


Ser Gly  Gly Gln Val Phe Ile  Ile Ser Val Glu Xaa  His Ala Val 
    1085                 1090                 1095             


Glu Gly  Gln Leu Glu Ala His  Gln Glu Glu Gly Met  Val Ile Ser 
    1100                 1105                 1110             


His Met  Ala Val Ser Gly Val  Gly Ile Trp Ile Ala  Phe Xaa Ser 
    1115                 1120                 1125             


Gly Ser  Xaa Leu Arg Leu Phe  His Xaa Glu Xaa Leu  Lys His Leu 
    1130                 1135                 1140             


Gln Asp  Ile Asn Ile Ala Xaa  Pro Val His Asn Met  Leu Pro Gly 
    1145                 1150                 1155             


His Gln  Arg Leu Ser Val Xaa  Ser Leu Leu Val Cys  His Gly Leu 
    1160                 1165                 1170             


Leu Met  Val Gly Xaa Ser Leu  Gly Val Leu Val Ala  Leu Pro Val 
    1175                 1180                 1185             


Pro Arg  Leu Gln Gly Ile Pro  Lys Val Xaa Gly Arg  Gly Met Val 
    1190                 1195                 1200             


Ser Tyr  His Ala His Asn Ser  Pro Val Lys Phe Ile  Val Leu Ala 
    1205                 1210                 1215             


Xaa Ala  Leu His Glu Lys Asp  Lys Asp Lys Ser Arg  Asp Ser Leu 
    1220                 1225                 1230             


Ala Pro  Gly Pro Glu Pro Gln  Asp Glu Asp Gln Lys  Asp Ala Leu 
    1235                 1240                 1245             


Pro Ser  Gly Gly Ala Gly Ser  Ser Leu Ser Gln Gly  Asp Pro Asp 
    1250                 1255                 1260             


Ala Ala  Ile Trp Leu Gly Asp  Ser Leu Gly Ser Met  Xaa Gln Lys 
    1265                 1270                 1275             


Ser Asp  Leu Ser Ser Ser Ser  Gly Ser Leu Ser Leu  Ser His Gly 
    1280                 1285                 1290             


Ser Ser  Ser Leu Glu His Arg  Ser Glu Asp Ser Xaa  Ile Tyr Asp 
    1295                 1300                 1305             


Leu Leu  Lys Asp Pro Val Ser  Leu Arg Ser Lys Ala  Arg Arg Ala 
    1310                 1315                 1320             


Lys Lys  Ala Lys Ala Ser Ser  Ala Leu Val Val Cys  Gly Gly Gln 
    1325                 1330                 1335             


Gly His  Arg Arg Val His Arg  Lys Ala Arg Gln Pro  His Gln Glu 
    1340                 1345                 1350             


Glu Leu  Ala Pro Xaa Val Met  Val Trp Gln Ile Pro  Leu Leu Asn 
    1355                 1360                 1365             


Ile 
    


<210> 2961
<211> 611
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(596)
<223> Selenocysteine

<400> 2961
Lys Pro Ile Gln Arg Phe Pro Gln Phe Ile Leu Leu Leu Gln Asp Met 
1               5                   10                  15      


Leu Lys Asn Xaa Pro Arg Gly His Pro Asp Arg Leu Ser Leu Gln Leu 
            20                  25                  30          


Ala Leu Xaa Glu Leu Glu Xaa Leu Ala Glu Lys Leu Asn Glu Gln Lys 
        35                  40                  45              


Arg Leu Ala Asp Gln Val Ala Glu Ile Gln Gln Leu Xaa Lys Ser Val 
    50                  55                  60                  


Ser Asp Arg Ser Ser Leu Asn Lys Leu Leu Xaa Ser Gly Gln Arg Gln 
65                  70                  75                  80  


Leu Leu Leu Cys Glu Xaa Leu Xaa Glu Xaa Val Tyr Gly Asp Arg Gly 
                85                  90                  95      


Gln Leu Ile Lys Ser Lys Glu Arg Arg Val Phe Leu Leu Asn Asp Met 
            100                 105                 110         


Leu Val Cys Ala Asn Ile Asn Phe Lys Gly Gln Leu Glu Ile Ser Ser 
        115                 120                 125             


Leu Val Pro Leu Gly Pro Lys Tyr Val Val Lys Trp Asn Xaa Ala Leu 
    130                 135                 140                 


Pro Gln Val Gln Val Val Glu Val Gly Gln Asp Gly Gly Xaa Tyr Asp 
145                 150                 155                 160 


Lys Asp Asn Val Leu Ile Gln His Ser Gly Ala Lys Lys Ala Ser Ala 
                165                 170                 175     


Ser Gly Gln Ala Gln Asn Lys Val Tyr Leu Gly Pro Pro Arg Leu Phe 
            180                 185                 190         


Gln Glu Leu Gln Asp Leu Gln Lys Asp Leu Ala Val Val Glu Gln Ile 
        195                 200                 205             


Xaa Leu Leu Ile Ser Xaa Leu His Gly Xaa Tyr Gln Asn Leu Asn Met 
    210                 215                 220                 


Xaa Val Ala Gln Asp Trp Cys Leu Ala Leu Gln Arg Leu Met Arg Val 
225                 230                 235                 240 


Lys Glu Glu Glu Ile His Ser Ala Asn Lys Cys Arg Leu Arg Leu Leu 
                245                 250                 255     


Leu Pro Gly Lys Pro Asp Lys Ser Gly Arg Pro Ile Ser Phe Met Val 
            260                 265                 270         


Val Phe Ile Xaa Pro Asn Pro Leu Ser Lys Ile Ser Trp Val Asn Arg 
        275                 280                 285             


Leu His Leu Ala Lys Ile Gly Leu Arg Glu Glu Asn Gln Pro Gly Trp 
    290                 295                 300                 


Leu Cys Pro Asp Glu Asp Lys Lys Ser Lys Ala Pro Phe Trp Cys Pro 
305                 310                 315                 320 


Ile Leu Ala Cys Cys Ile Pro Ala Phe Ser Ser Arg Ala Leu Ser Leu 
                325                 330                 335     


Gln Leu Gly Ala Leu Val His Ser Pro Val Asn Cys Pro Leu Leu Gly 
            340                 345                 350         


Phe Ser Ala Val Ser Xaa Ser Leu Pro Gln Gly Tyr Leu Trp Val Gly 
        355                 360                 365             


Gly Gly Gln Glu Gly Ala Gly Gly Gln Val Glu Ile Phe Ser Leu Asn 
    370                 375                 380                 


Arg Pro Ser Pro Arg Xaa Val Lys Ser Phe Pro Leu Ala Ala Pro Val 
385                 390                 395                 400 


Leu Cys Met Glu Tyr Ile Pro Glu Leu Glu Glu Glu Ala Glu Ser Arg 
                405                 410                 415     


Asp Glu Ser Pro Xaa Val Ala Asp Pro Ser Ala Xaa Val His Pro Xaa 
            420                 425                 430         


Ile Cys Leu Gly Leu Gln Asp Gly Ser Ile Leu Leu Tyr Ser Ser Val 
        435                 440                 445             


Asp Xaa Gly Xaa Gln Cys Leu Val Ser Cys Arg Ser Pro Gly Leu Gln 
    450                 455                 460                 


Pro Val Leu Cys Leu Arg His Ser Pro Phe His Leu Leu Ala Gly Leu 
465                 470                 475                 480 


Gln Asp Gly Xaa Leu Ala Ala Tyr Pro Arg Xaa Ser Gly Gly Val Leu 
                485                 490                 495     


Trp Asp Leu Glu Ser Pro Pro Val Cys Leu Xaa Val Gly Pro Gly Pro 
            500                 505                 510         


Val Arg Xaa Leu Leu Ser Leu Glu Asp Ala Val Trp Ala Ser Cys Gly 
        515                 520                 525             


Pro Arg Val Xaa Val Leu Glu Ala Xaa Xaa Leu Gln Pro Gln Gln Ser 
    530                 535                 540                 


Phe Glu Ala His Gln Asp Glu Ala Val Ser Val Xaa His Met Val Lys 
545                 550                 555                 560 


Ala Gly Ser Gly Val Trp Met Ala Phe Ser Ser Gly Xaa Ser Ile Arg 
                565                 570                 575     


Leu Phe His Xaa Glu Xaa Leu Glu His Leu Gln Glu Ile Asn Ile Ala 
            580                 585                 590         


Xaa Arg Xaa Xaa Phe Leu Leu Pro Asp Arg Ser Leu Ile Lys Cys Ser 
        595                 600                 605             


Pro Arg Ala 
    610     


<210> 2962
<211> 1279
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1017)..(1017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1123)..(1123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<400> 2962
Met Ala Ser Ser Asn Pro Pro Pro Gln Pro Ala Ile Gly Asp Gln Leu 
1               5                   10                  15      


Val Pro Gly Val Pro Gly Pro Ser Ser Glu Ala Glu Asp Asp Pro Gly 
            20                  25                  30          


Glu Ala Phe Glu Phe Asp Asp Ser Asp Asp Glu Glu Asp Xaa Ser Ala 
        35                  40                  45              


Ala Leu Gly Val Pro Ser Leu Ala Pro Glu Arg Asp Xaa Asp Pro Pro 
    50                  55                  60                  


Leu Ile His Leu Asp Ser Ile Pro Val Xaa Asp Pro Asp Pro Ala Ala 
65                  70                  75                  80  


Ala Pro Pro Gly Xaa Gly Val Pro Ala Trp Val Ser Asn Gly Asp Ala 
                85                  90                  95      


Ala Asp Ala Ala Phe Ser Gly Ala Arg His Ser Ser Trp Lys Arg Lys 
            100                 105                 110         


Ser Ser Arg Arg Ile Asp Arg Phe Xaa Phe Pro Ala Leu Glu Glu Asp 
        115                 120                 125             


Val Ile Tyr Asp Asp Val Pro Cys Glu Ser Pro Asp Ala His Gln Pro 
    130                 135                 140                 


Gly Ala Glu Arg Asn Leu Leu Tyr Glu Asp Ala His Arg Ala Gly Ala 
145                 150                 155                 160 


Pro Arg Gln Ala Glu Asp Leu Gly Trp Ser Ser Ser Glu Phe Glu Ser 
                165                 170                 175     


Tyr Ser Glu Asp Ser Gly Glu Glu Ala Lys Pro Glu Val Glu Val Glu 
            180                 185                 190         


Pro Ala Lys His Arg Val Ser Phe Gln Pro Lys Leu Ser Pro Asp Leu 
        195                 200                 205             


Xaa Arg Leu Lys Glu Arg Tyr Ala Arg Xaa Lys Arg Asp Ile Leu Ala 
    210                 215                 220                 


Leu Arg Val Gly Gly Arg Asp Met Gln Glu Leu Lys His Lys Tyr Asp 
225                 230                 235                 240 


Cys Lys Met Xaa Gln Leu Met Lys Ala Ala Lys Ser Gly Xaa Lys Asp 
                245                 250                 255     


Gly Leu Glu Lys Xaa Arg Met Ala Val Met Arg Lys Val Ser Phe Leu 
            260                 265                 270         


His Arg Lys Asp Val Leu Gly Asp Ser Glu Glu Glu Asp Met Gly Leu 
        275                 280                 285             


Leu Glu Val Ser Val Ser Asp Ile Lys Pro Pro Ala Pro Glu Leu Gly 
    290                 295                 300                 


Pro Met Pro Glu Gly Leu Ser Pro Gln Gln Val Val Arg Arg His Ile 
305                 310                 315                 320 


Leu Gly Ser Ile Val Gln Ser Glu Gly Ser Tyr Val Glu Ser Leu Lys 
                325                 330                 335     


Arg Ile Leu Gln Asp Tyr Arg Asn Pro Leu Met Glu Met Glu Pro Lys 
            340                 345                 350         


Ala Leu Ser Ala Arg Lys Cys Gln Val Val Phe Phe Arg Val Lys Glu 
        355                 360                 365             


Ile Leu His Cys His Ser Met Phe Gln Ile Ala Leu Ser Ser Arg Val 
    370                 375                 380                 


Ala Glu Trp Asp Ser Xaa Glu Lys Ile Gly Asp Leu Phe Val Ala Ser 
385                 390                 395                 400 


Phe Ser Lys Ser Met Val Leu Asp Val Tyr Ser Asp Tyr Val Asn Asn 
                405                 410                 415     


Phe Xaa Ser Ala Met Ser Ile Ile Lys Lys Ala Cys Leu Xaa Lys Pro 
            420                 425                 430         


Ala Phe Leu Glu Phe Leu Lys Arg Arg Gln Val Cys Ser Pro Asp Arg 
        435                 440                 445             


Val Xaa Leu Tyr Gly Leu Met Val Lys Pro Ile Gln Arg Phe Pro Gln 
    450                 455                 460                 


Phe Ile Leu Leu Leu Gln Asp Met Leu Lys Asn Xaa Pro Arg Gly His 
465                 470                 475                 480 


Pro Asp Arg Leu Ser Leu Gln Leu Ala Leu Xaa Glu Leu Glu Xaa Leu 
                485                 490                 495     


Ala Glu Lys Leu Asn Glu Gln Lys Arg Leu Ala Asp Gln Val Ala Glu 
            500                 505                 510         


Ile Gln Gln Leu Xaa Lys Ser Val Ser Asp Arg Ser Ser Leu Asn Lys 
        515                 520                 525             


Leu Leu Xaa Ser Gly Gln Arg Gln Leu Leu Leu Cys Glu Xaa Leu Xaa 
    530                 535                 540                 


Glu Xaa Val Tyr Gly Asp Arg Gly Gln Leu Ile Lys Ser Lys Glu Arg 
545                 550                 555                 560 


Arg Val Phe Leu Leu Asn Asp Met Leu Val Cys Ala Asn Ile Asn Phe 
                565                 570                 575     


Lys Pro Ala Asn His Arg Gly Gln Leu Glu Ile Ser Ser Leu Val Pro 
            580                 585                 590         


Leu Gly Pro Lys Tyr Val Val Lys Trp Asn Xaa Ala Leu Pro Gln Val 
        595                 600                 605             


Gln Val Val Glu Val Gly Gln Asp Gly Gly Xaa Tyr Asp Lys Asp Asn 
    610                 615                 620                 


Val Leu Ile Gln His Ser Gly Ala Lys Lys Ala Ser Ala Ser Gly Gln 
625                 630                 635                 640 


Ala Gln Asn Lys Val Tyr Leu Gly Pro Pro Arg Leu Phe Gln Glu Leu 
                645                 650                 655     


Gln Asp Leu Gln Lys Asp Leu Ala Val Val Glu Gln Ile Xaa Leu Leu 
            660                 665                 670         


Ile Ser Xaa Leu His Gly Xaa Tyr Gln Asn Leu Asn Met Xaa Val Ala 
        675                 680                 685             


Gln Asp Trp Cys Leu Ala Leu Gln Arg Leu Met Arg Val Lys Glu Glu 
    690                 695                 700                 


Glu Ile His Ser Ala Asn Lys Cys Arg Leu Arg Leu Leu Leu Pro Gly 
705                 710                 715                 720 


Lys Pro Asp Lys Ser Gly Arg Pro Ile Ser Phe Met Val Val Phe Ile 
                725                 730                 735     


Xaa Pro Asn Pro Leu Ser Lys Ile Ser Trp Val Asn Arg Leu His Leu 
            740                 745                 750         


Ala Lys Ile Gly Leu Arg Glu Glu Asn Gln Pro Gly Trp Leu Cys Pro 
        755                 760                 765             


Asp Glu Asp Lys Lys Ser Lys Ala Pro Phe Trp Cys Pro Ile Leu Ala 
    770                 775                 780                 


Cys Cys Ile Pro Ala Phe Ser Ser Arg Ala Leu Ser Leu Gln Leu Gly 
785                 790                 795                 800 


Ala Leu Val His Ser Pro Val Asn Cys Pro Leu Leu Gly Phe Ser Ala 
                805                 810                 815     


Val Ser Xaa Ser Leu Pro Gln Gly Tyr Leu Trp Val Gly Gly Gly Gln 
            820                 825                 830         


Glu Gly Ala Gly Gly Gln Val Glu Ile Phe Ser Leu Asn Arg Pro Ser 
        835                 840                 845             


Pro Arg Xaa Val Lys Ser Phe Pro Leu Ala Ala Pro Val Leu Cys Met 
    850                 855                 860                 


Glu Tyr Ile Pro Glu Leu Glu Glu Glu Ala Glu Ser Arg Asp Glu Ser 
865                 870                 875                 880 


Pro Xaa Val Ala Asp Pro Ser Ala Xaa Val His Pro Xaa Ile Cys Leu 
                885                 890                 895     


Gly Leu Gln Asp Gly Ser Ile Leu Leu Tyr Ser Ser Val Asp Xaa Gly 
            900                 905                 910         


Xaa Gln Cys Leu Val Ser Cys Arg Ser Pro Gly Leu Gln Pro Val Leu 
        915                 920                 925             


Cys Leu Arg His Ser Pro Phe His Leu Leu Ala Gly Leu Gln Asp Gly 
    930                 935                 940                 


Xaa Leu Ala Ala Tyr Pro Arg Xaa Ser Gly Gly Val Leu Trp Asp Leu 
945                 950                 955                 960 


Glu Ser Pro Pro Val Cys Leu Xaa Val Gly Pro Gly Pro Val Arg Xaa 
                965                 970                 975     


Leu Leu Ser Leu Glu Asp Ala Val Trp Ala Ser Cys Gly Pro Arg Val 
            980                 985                 990         


Xaa Val Leu Glu Ala Xaa Xaa Leu  Gln Pro Gln Gln Ser  Phe Glu Ala 
        995                 1000                 1005             


His Gln  Asp Glu Ala Val Ser  Val Xaa His Met Val  Lys Ala Gly 
    1010                 1015                 1020             


Ser Gly  Val Trp Met Ala Phe  Ser Ser Gly Xaa Ser  Ile Arg Leu 
    1025                 1030                 1035             


Phe His  Xaa Glu Xaa Leu Glu  His Leu Gln Glu Ile  Asn Ile Ala 
    1040                 1045                 1050             


Xaa Arg  Xaa Xaa Phe Leu Leu  Pro Gly Gln Lys His  Leu Cys Val 
    1055                 1060                 1065             


Xaa Ser  Leu Leu Ile Cys Gln  Gly Leu Leu Trp Val  Gly Xaa Asp 
    1070                 1075                 1080             


Gln Gly  Val Ile Val Leu Leu  Pro Val Pro Arg Leu  Glu Gly Ile 
    1085                 1090                 1095             


Pro Lys  Ile Xaa Gly Lys Gly  Met Val Ser Leu Asn  Gly His Cys 
    1100                 1105                 1110             


Gly Pro  Val Ala Phe Leu Ala  Val Ala Xaa Ser Ile  Leu Ala Pro 
    1115                 1120                 1125             


Asp Ile  Leu Arg Ser Asp Gln  Glu Glu Ala Glu Gly  Pro Arg Ala 
    1130                 1135                 1140             


Glu Glu  Asp Lys Pro Asp Gly  Gln Ala His Glu Pro  Met Pro Asp 
    1145                 1150                 1155             


Ser His  Val Gly Arg Glu Leu  Xaa Arg Lys Lys Gly  Ile Leu Leu 
    1160                 1165                 1170             


Gln Tyr  Arg Leu Arg Ser Xaa  Ala His Leu Pro Gly  Pro Leu Leu 
    1175                 1180                 1185             


Ser Met  Arg Glu Pro Ala Pro  Ala Asp Gly Ala Ala  Leu Glu His 
    1190                 1195                 1200             


Ser Glu  Glu Asp Gly Ser Ile  Tyr Glu Met Ala Asp  Asp Pro Asp 
    1205                 1210                 1215             


Ile Trp  Val Arg Ser Arg Pro  Cys Ala Arg Asp Ala  His Arg Lys 
    1220                 1225                 1230             


Glu Ile  Cys Ser Val Ala Ile  Ile Ser Gly Gly Gln  Gly Tyr Arg 
    1235                 1240                 1245             


Asn Phe  Gly Ser Ala Leu Gly  Ser Ser Gly Arg Gln  Ala Pro Cys 
    1250                 1255                 1260             


Gly Glu  Xaa Asp Ser Xaa Leu  Leu Ile Trp Gln Val  Pro Leu Met 
    1265                 1270                 1275             


Leu 
    


<210> 2963
<211> 1240
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1017)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<400> 2963
Met Ala Ser Ser Asn Pro Pro Pro Gln Pro Ala Ile Gly Asp Gln Leu 
1               5                   10                  15      


Val Pro Gly Val Pro Gly Pro Ser Ser Glu Ala Glu Asp Asp Pro Gly 
            20                  25                  30          


Glu Ala Phe Glu Phe Asp Asp Ser Asp Asp Glu Glu Asp Xaa Ser Ala 
        35                  40                  45              


Ala Leu Gly Val Pro Ser Leu Ala Pro Glu Arg Asp Xaa Asp Pro Pro 
    50                  55                  60                  


Leu Ile His Leu Asp Ser Ile Pro Val Xaa Asp Pro Asp Pro Ala Ala 
65                  70                  75                  80  


Ala Pro Pro Gly Xaa Gly Val Pro Ala Trp Val Ser Asn Gly Asp Ala 
                85                  90                  95      


Ala Asp Ala Ala Phe Ser Gly Ala Arg His Ser Ser Trp Lys Arg Lys 
            100                 105                 110         


Ser Ser Arg Arg Ile Asp Arg Phe Xaa Phe Pro Ala Leu Glu Glu Asp 
        115                 120                 125             


Val Ile Tyr Asp Asp Val Pro Cys Glu Ser Pro Asp Ala His Gln Pro 
    130                 135                 140                 


Gly Ala Glu Arg Asn Leu Leu Tyr Glu Asp Ala His Arg Ala Gly Ala 
145                 150                 155                 160 


Pro Arg Gln Ala Glu Asp Leu Gly Trp Ser Ser Ser Glu Phe Glu Ser 
                165                 170                 175     


Tyr Ser Glu Asp Ser Gly Glu Glu Ala Lys Pro Glu Val Glu Val Glu 
            180                 185                 190         


Pro Ala Lys His Arg Val Ser Phe Gln Pro Lys Met Xaa Gln Leu Met 
        195                 200                 205             


Lys Ala Ala Lys Ser Gly Xaa Lys Asp Gly Leu Glu Lys Xaa Arg Met 
    210                 215                 220                 


Ala Val Met Arg Lys Val Ser Phe Leu His Arg Lys Asp Val Leu Gly 
225                 230                 235                 240 


Asp Ser Glu Glu Glu Asp Met Gly Leu Leu Glu Val Ser Val Ser Asp 
                245                 250                 255     


Ile Lys Pro Pro Ala Pro Glu Leu Gly Pro Met Pro Glu Gly Leu Ser 
            260                 265                 270         


Pro Gln Gln Val Val Arg Arg His Ile Leu Gly Ser Ile Val Gln Ser 
        275                 280                 285             


Glu Gly Ser Tyr Val Glu Ser Leu Lys Arg Ile Leu Gln Asp Tyr Arg 
    290                 295                 300                 


Asn Pro Leu Met Glu Met Glu Pro Lys Ala Leu Ser Ala Arg Lys Cys 
305                 310                 315                 320 


Gln Val Val Phe Phe Arg Val Lys Glu Ile Leu His Cys His Ser Met 
                325                 330                 335     


Phe Gln Ile Ala Leu Ser Ser Arg Val Ala Glu Trp Asp Ser Xaa Glu 
            340                 345                 350         


Lys Ile Gly Asp Leu Phe Val Ala Ser Phe Ser Lys Ser Met Val Leu 
        355                 360                 365             


Asp Val Tyr Ser Asp Tyr Val Asn Asn Phe Xaa Ser Ala Met Ser Ile 
    370                 375                 380                 


Ile Lys Lys Ala Cys Leu Xaa Lys Pro Ala Phe Leu Glu Phe Leu Lys 
385                 390                 395                 400 


Arg Arg Gln Val Cys Ser Pro Asp Arg Val Xaa Leu Tyr Gly Leu Met 
                405                 410                 415     


Val Lys Pro Ile Gln Arg Phe Pro Gln Phe Ile Leu Leu Leu Gln Asp 
            420                 425                 430         


Met Leu Lys Asn Xaa Pro Arg Gly His Pro Asp Arg Leu Ser Leu Gln 
        435                 440                 445             


Leu Ala Leu Xaa Glu Leu Glu Xaa Leu Ala Glu Lys Leu Asn Glu Gln 
    450                 455                 460                 


Lys Arg Leu Ala Asp Gln Val Ala Glu Ile Gln Gln Leu Xaa Lys Ser 
465                 470                 475                 480 


Val Ser Asp Arg Ser Ser Leu Asn Lys Leu Leu Xaa Ser Gly Gln Arg 
                485                 490                 495     


Gln Leu Leu Leu Cys Glu Xaa Leu Xaa Glu Xaa Val Tyr Gly Asp Arg 
            500                 505                 510         


Gly Gln Leu Ile Lys Ser Lys Glu Arg Arg Val Phe Leu Leu Asn Asp 
        515                 520                 525             


Met Leu Val Cys Ala Asn Ile Asn Phe Lys Pro Ala Asn His Arg Gly 
    530                 535                 540                 


Gln Leu Glu Ile Ser Ser Leu Val Pro Leu Gly Pro Lys Tyr Val Val 
545                 550                 555                 560 


Lys Trp Asn Xaa Ala Leu Pro Gln Val Gln Val Val Glu Val Gly Gln 
                565                 570                 575     


Asp Gly Gly Xaa Tyr Asp Lys Asp Asn Val Leu Ile Gln His Ser Gly 
            580                 585                 590         


Ala Lys Lys Ala Ser Ala Ser Gly Gln Ala Gln Asn Lys Val Tyr Leu 
        595                 600                 605             


Gly Pro Pro Arg Leu Phe Gln Glu Leu Gln Asp Leu Gln Lys Asp Leu 
    610                 615                 620                 


Ala Val Val Glu Gln Ile Xaa Leu Leu Ile Ser Xaa Leu His Gly Xaa 
625                 630                 635                 640 


Tyr Gln Asn Leu Asn Met Xaa Val Ala Gln Asp Trp Cys Leu Ala Leu 
                645                 650                 655     


Gln Arg Leu Met Arg Val Lys Glu Glu Glu Ile His Ser Ala Asn Lys 
            660                 665                 670         


Cys Arg Leu Arg Leu Leu Leu Pro Gly Lys Pro Asp Lys Ser Gly Arg 
        675                 680                 685             


Pro Ile Ser Phe Met Val Val Phe Ile Xaa Pro Asn Pro Leu Ser Lys 
    690                 695                 700                 


Ile Ser Trp Val Asn Arg Leu His Leu Ala Lys Ile Gly Leu Arg Glu 
705                 710                 715                 720 


Glu Asn Gln Pro Gly Trp Leu Cys Pro Asp Glu Asp Lys Lys Ser Lys 
                725                 730                 735     


Ala Pro Phe Trp Cys Pro Ile Leu Ala Cys Cys Ile Pro Ala Phe Ser 
            740                 745                 750         


Ser Arg Ala Leu Ser Leu Gln Leu Gly Ala Leu Val His Ser Pro Val 
        755                 760                 765             


Asn Cys Pro Leu Leu Gly Phe Ser Ala Val Ser Xaa Ser Leu Pro Gln 
    770                 775                 780                 


Gly Tyr Leu Trp Val Gly Gly Gly Gln Glu Gly Ala Gly Gly Gln Val 
785                 790                 795                 800 


Glu Ile Phe Ser Leu Asn Arg Pro Ser Pro Arg Xaa Val Lys Ser Phe 
                805                 810                 815     


Pro Leu Ala Ala Pro Val Leu Cys Met Glu Tyr Ile Pro Glu Leu Glu 
            820                 825                 830         


Glu Glu Ala Glu Ser Arg Asp Glu Ser Pro Xaa Val Ala Asp Pro Ser 
        835                 840                 845             


Ala Xaa Val His Pro Xaa Ile Cys Leu Gly Leu Gln Asp Gly Ser Ile 
    850                 855                 860                 


Leu Leu Tyr Ser Ser Val Asp Xaa Gly Xaa Gln Cys Leu Val Ser Cys 
865                 870                 875                 880 


Arg Ser Pro Gly Leu Gln Pro Val Leu Cys Leu Arg His Ser Pro Phe 
                885                 890                 895     


His Leu Leu Ala Gly Leu Gln Asp Gly Xaa Leu Ala Ala Tyr Pro Arg 
            900                 905                 910         


Xaa Ser Gly Gly Val Leu Trp Asp Leu Glu Ser Pro Pro Val Cys Leu 
        915                 920                 925             


Xaa Val Gly Pro Gly Pro Val Arg Xaa Leu Leu Ser Leu Glu Asp Ala 
    930                 935                 940                 


Val Trp Ala Ser Cys Gly Pro Arg Val Xaa Val Leu Glu Ala Xaa Xaa 
945                 950                 955                 960 


Leu Gln Pro Gln Gln Ser Phe Glu Ala His Gln Asp Glu Ala Val Ser 
                965                 970                 975     


Val Xaa His Met Val Lys Ala Gly Ser Gly Val Trp Met Ala Phe Ser 
            980                 985                 990         


Ser Gly Xaa Ser Ile Arg Leu Phe  His Xaa Glu Xaa Leu  Glu His Leu 
        995                 1000                 1005             


Gln Glu  Ile Asn Ile Ala Xaa  Arg Xaa Xaa Phe Leu  Leu Pro Gly 
    1010                 1015                 1020             


Gln Lys  His Leu Cys Val Xaa  Ser Leu Leu Ile Cys  Gln Gly Leu 
    1025                 1030                 1035             


Leu Trp  Val Gly Xaa Asp Gln  Gly Val Ile Val Leu  Leu Pro Val 
    1040                 1045                 1050             


Pro Arg  Leu Glu Gly Ile Pro  Lys Ile Xaa Gly Lys  Gly Met Val 
    1055                 1060                 1065             


Ser Leu  Asn Gly His Cys Gly  Pro Val Ala Phe Leu  Ala Val Ala 
    1070                 1075                 1080             


Xaa Ser  Ile Leu Ala Pro Asp  Ile Leu Arg Ser Asp  Gln Glu Glu 
    1085                 1090                 1095             


Ala Glu  Gly Pro Arg Ala Glu  Glu Asp Lys Pro Asp  Gly Gln Ala 
    1100                 1105                 1110             


His Glu  Pro Met Pro Asp Ser  His Val Gly Arg Glu  Leu Xaa Arg 
    1115                 1120                 1125             


Lys Lys  Gly Ile Leu Leu Gln  Tyr Arg Leu Arg Ser  Xaa Ala His 
    1130                 1135                 1140             


Leu Pro  Gly Pro Leu Leu Ser  Met Arg Glu Pro Ala  Pro Ala Asp 
    1145                 1150                 1155             


Gly Ala  Ala Leu Glu His Ser  Glu Glu Asp Gly Ser  Ile Tyr Glu 
    1160                 1165                 1170             


Met Ala  Asp Asp Pro Asp Ile  Trp Val Arg Ser Arg  Pro Cys Ala 
    1175                 1180                 1185             


Arg Asp  Ala His Arg Lys Glu  Ile Cys Ser Val Ala  Ile Ile Ser 
    1190                 1195                 1200             


Gly Gly  Gln Gly Tyr Arg Asn  Phe Gly Ser Ala Leu  Gly Ser Ser 
    1205                 1210                 1215             


Gly Arg  Gln Ala Pro Cys Gly  Glu Xaa Asp Ser Xaa  Leu Leu Ile 
    1220                 1225                 1230             


Trp Gln  Val Pro Leu Met Leu  
    1235                 1240 


<210> 2964
<211> 1052
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<400> 2964
Met Leu Pro Ser Ser Ser Trp Gly Lys Arg Lys Leu Arg Gly Arg Leu 
1               5                   10                  15      


Gly Trp Val Arg Ser Asp Ala Arg Gly Val Met Trp Ala Arg Gln Glu 
            20                  25                  30          


Gly Leu His His Pro His Pro His Ala Val Ile Arg Cys Pro Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Val Ser Cys Ser Gly Asp Ser Glu Glu Glu Asp Met 
    50                  55                  60                  


Gly Leu Leu Glu Val Ser Val Ser Asp Ile Lys Pro Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Gly Pro Met Pro Glu Gly Leu Ser Pro Gln Gln Val Val Arg Arg 
                85                  90                  95      


His Ile Leu Gly Ser Ile Val Gln Ser Glu Gly Ser Tyr Val Glu Ser 
            100                 105                 110         


Leu Lys Arg Ile Leu Gln Asp Tyr Arg Asn Pro Leu Met Glu Met Glu 
        115                 120                 125             


Pro Lys Ala Leu Ser Ala Arg Lys Cys Gln Val Val Phe Phe Arg Val 
    130                 135                 140                 


Lys Glu Ile Leu His Cys His Ser Met Phe Gln Ile Ala Leu Ser Ser 
145                 150                 155                 160 


Arg Val Ala Glu Trp Asp Ser Xaa Glu Lys Ile Gly Asp Leu Phe Val 
                165                 170                 175     


Ala Ser Phe Ser Lys Ser Met Val Leu Asp Val Tyr Ser Asp Tyr Val 
            180                 185                 190         


Asn Asn Phe Xaa Ser Ala Met Ser Ile Ile Lys Lys Ala Cys Leu Xaa 
        195                 200                 205             


Lys Pro Ala Phe Leu Glu Phe Leu Lys Arg Arg Gln Val Cys Ser Pro 
    210                 215                 220                 


Asp Arg Val Xaa Leu Tyr Gly Leu Met Val Lys Pro Ile Gln Arg Phe 
225                 230                 235                 240 


Pro Gln Phe Ile Leu Leu Leu Gln Asp Met Leu Lys Asn Xaa Pro Arg 
                245                 250                 255     


Gly His Pro Asp Arg Leu Ser Leu Gln Leu Ala Leu Xaa Glu Leu Glu 
            260                 265                 270         


Xaa Leu Ala Glu Lys Leu Asn Glu Gln Lys Arg Leu Ala Asp Gln Val 
        275                 280                 285             


Ala Glu Ile Gln Gln Leu Xaa Lys Ser Val Ser Asp Arg Ser Ser Leu 
    290                 295                 300                 


Asn Lys Leu Leu Xaa Ser Gly Gln Arg Gln Leu Leu Leu Cys Glu Xaa 
305                 310                 315                 320 


Leu Xaa Glu Xaa Val Tyr Gly Asp Arg Gly Gln Leu Ile Lys Ser Lys 
                325                 330                 335     


Glu Arg Arg Val Phe Leu Leu Asn Asp Met Leu Val Cys Ala Asn Ile 
            340                 345                 350         


Asn Phe Lys Gly Gln Leu Glu Ile Ser Ser Leu Val Pro Leu Gly Pro 
        355                 360                 365             


Lys Tyr Val Val Lys Trp Asn Xaa Ala Leu Pro Gln Val Gln Val Val 
    370                 375                 380                 


Glu Val Gly Gln Asp Gly Gly Xaa Tyr Asp Lys Asp Asn Val Leu Ile 
385                 390                 395                 400 


Gln His Ser Gly Ala Lys Lys Ala Ser Ala Ser Gly Gln Ala Gln Asn 
                405                 410                 415     


Lys Val Tyr Leu Gly Pro Pro Arg Leu Phe Gln Glu Leu Gln Asp Leu 
            420                 425                 430         


Gln Lys Asp Leu Ala Val Val Glu Gln Ile Xaa Leu Leu Ile Ser Xaa 
        435                 440                 445             


Leu His Gly Xaa Tyr Gln Asn Leu Asn Met Xaa Val Ala Gln Asp Trp 
    450                 455                 460                 


Cys Leu Ala Leu Gln Arg Leu Met Arg Val Lys Glu Glu Glu Ile His 
465                 470                 475                 480 


Ser Ala Asn Lys Cys Arg Leu Arg Leu Leu Leu Pro Gly Lys Pro Asp 
                485                 490                 495     


Lys Ser Gly Arg Pro Ile Ser Phe Met Val Val Phe Ile Xaa Pro Asn 
            500                 505                 510         


Pro Leu Ser Lys Ile Ser Trp Val Asn Arg Leu His Leu Ala Lys Ile 
        515                 520                 525             


Gly Leu Arg Glu Glu Asn Gln Pro Gly Trp Leu Cys Pro Asp Glu Asp 
    530                 535                 540                 


Lys Lys Ser Lys Ala Pro Phe Trp Cys Pro Ile Leu Ala Cys Cys Ile 
545                 550                 555                 560 


Pro Ala Phe Ser Ser Arg Ala Leu Ser Leu Gln Leu Gly Ala Leu Val 
                565                 570                 575     


His Ser Pro Val Asn Cys Pro Leu Leu Gly Phe Ser Ala Val Ser Xaa 
            580                 585                 590         


Ser Leu Pro Gln Gly Tyr Leu Trp Val Gly Gly Gly Gln Glu Gly Ala 
        595                 600                 605             


Gly Gly Gln Val Glu Ile Phe Ser Leu Asn Arg Pro Ser Pro Arg Xaa 
    610                 615                 620                 


Val Lys Ser Phe Pro Leu Ala Ala Pro Val Leu Cys Met Glu Tyr Ile 
625                 630                 635                 640 


Pro Glu Leu Glu Glu Glu Ala Glu Ser Arg Asp Glu Ser Pro Xaa Val 
                645                 650                 655     


Ala Asp Pro Ser Ala Xaa Val His Pro Xaa Ile Cys Leu Gly Leu Gln 
            660                 665                 670         


Asp Gly Ser Ile Leu Leu Tyr Ser Ser Val Asp Xaa Gly Xaa Gln Cys 
        675                 680                 685             


Leu Val Ser Cys Arg Ser Pro Gly Leu Gln Pro Val Leu Cys Leu Arg 
    690                 695                 700                 


His Ser Pro Phe His Leu Leu Ala Gly Leu Gln Asp Gly Xaa Leu Ala 
705                 710                 715                 720 


Ala Tyr Pro Arg Xaa Ser Gly Gly Val Leu Trp Asp Leu Glu Ser Pro 
                725                 730                 735     


Pro Val Cys Leu Xaa Val Gly Pro Gly Pro Val Arg Xaa Leu Leu Ser 
            740                 745                 750         


Leu Glu Asp Ala Val Trp Ala Ser Cys Gly Pro Arg Val Xaa Val Leu 
        755                 760                 765             


Glu Ala Xaa Xaa Leu Gln Pro Gln Gln Ser Phe Glu Ala His Gln Asp 
    770                 775                 780                 


Glu Ala Val Ser Val Xaa His Met Val Lys Ala Gly Ser Gly Val Trp 
785                 790                 795                 800 


Met Ala Phe Ser Ser Gly Xaa Ser Ile Arg Leu Phe His Xaa Glu Xaa 
                805                 810                 815     


Leu Glu His Leu Gln Glu Ile Asn Ile Ala Xaa Arg Xaa Xaa Phe Leu 
            820                 825                 830         


Leu Pro Gly Gln Lys His Leu Cys Val Xaa Ser Leu Leu Ile Cys Gln 
        835                 840                 845             


Gly Leu Leu Trp Val Gly Xaa Asp Gln Gly Val Ile Val Leu Leu Pro 
    850                 855                 860                 


Val Pro Arg Leu Glu Gly Ile Pro Lys Ile Xaa Gly Lys Gly Met Val 
865                 870                 875                 880 


Ser Leu Asn Gly His Cys Gly Pro Val Ala Phe Leu Ala Val Ala Xaa 
                885                 890                 895     


Ser Ile Leu Ala Pro Asp Ile Leu Arg Ser Asp Gln Glu Glu Ala Glu 
            900                 905                 910         


Gly Pro Arg Ala Glu Glu Asp Lys Pro Asp Gly Gln Ala His Glu Pro 
        915                 920                 925             


Met Pro Asp Ser His Val Gly Arg Glu Leu Xaa Arg Lys Lys Gly Ile 
    930                 935                 940                 


Leu Leu Gln Tyr Arg Leu Arg Ser Xaa Ala His Leu Pro Gly Pro Leu 
945                 950                 955                 960 


Leu Ser Met Arg Glu Pro Ala Pro Ala Asp Gly Ala Ala Leu Glu His 
                965                 970                 975     


Ser Glu Glu Asp Gly Ser Ile Tyr Glu Met Ala Asp Asp Pro Asp Ile 
            980                 985                 990         


Trp Val Arg Ser Arg Pro Cys Ala  Arg Asp Ala His Arg  Lys Glu Ile 
        995                 1000                 1005             


Cys Ser  Val Ala Ile Ile Ser  Gly Gly Gln Gly Tyr  Arg Asn Phe 
    1010                 1015                 1020             


Gly Ser  Ala Leu Gly Ser Ser  Gly Arg Gln Ala Pro  Cys Gly Glu 
    1025                 1030                 1035             


Xaa Asp  Ser Xaa Leu Leu Ile  Trp Gln Val Pro Leu  Met Leu 
    1040                 1045                 1050         


<210> 2965
<211> 1522
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1108)..(1108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1221)..(1221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1224)..(1224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1235)..(1235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1237)..(1237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1244)..(1244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1314)..(1314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1354)..(1354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1357)..(1357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1374)..(1374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1394)..(1394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1428)..(1428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1433)..(1433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1461)..(1462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1469)..(1469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1475)..(1475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<400> 2965
Met Ser Val Arg Leu Pro Gln Ser Ile Asp Arg Leu Ser Ser Leu Ser 
1               5                   10                  15      


Ser Leu Gly Asp Ser Ala Pro Glu Arg Lys Ser Pro Ser His His Arg 
            20                  25                  30          


Gln Pro Ser Asp Ala Ser Glu Xaa Xaa Gly Leu Val Gln Arg Cys Val 
        35                  40                  45              


Ile Ile Gln Lys Asp Gln His Gly Phe Gly Phe Xaa Val Ser Gly Asp 
    50                  55                  60                  


Arg Ile Val Leu Val Gln Ser Val Arg Pro Gly Gly Ala Ala Met Lys 
65                  70                  75                  80  


Ala Gly Val Lys Glu Gly Asp Arg Ile Ile Lys Val Asn Gly Xaa Met 
                85                  90                  95      


Val Xaa Asn Ser Ser His Leu Glu Val Val Lys Leu Ile Lys Ser Gly 
            100                 105                 110         


Ala Tyr Val Ala Leu Xaa Leu Leu Gly Ser Ser Pro Ser Ser Met Gly 
        115                 120                 125             


Ile Ser Gly Leu Gln Gln Asp Pro Ser Pro Ala Gly Ala Pro Arg Ile 
    130                 135                 140                 


Xaa Ser Val Ile Pro Ser Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro 
145                 150                 155                 160 


Gln Arg Ile Xaa Gly Pro Lys Pro Leu Gln Asp Pro Glu Val Gln Lys 
                165                 170                 175     


His Ala Xaa Gln Ile Leu Arg Asn Met Leu Arg Gln Glu Glu Lys Glu 
            180                 185                 190         


Leu Gln Asp Ile Leu Pro Leu Tyr Gly Asp Xaa Ser Gln Arg Pro Ser 
        195                 200                 205             


Glu Gly Arg Leu Ser Leu Asp Ser Gln Glu Gly Asp Ser Gly Leu Asp 
    210                 215                 220                 


Ser Gly Xaa Glu Arg Phe Pro Ser Leu Ser Glu Ser Leu Met Asn Arg 
225                 230                 235                 240 


Asn Ser Val Leu Ser Asp Pro Gly Leu Asp Ser Pro Arg Xaa Ser Pro 
                245                 250                 255     


Val Ile Met Ala Arg Val Ala Gln His His Arg Arg Gln Gly Ser Asp 
            260                 265                 270         


Ala Ala Val Pro Ser Xaa Gly Asp Gln Gly Val Asp Gln Ser Pro Lys 
        275                 280                 285             


Pro Leu Ile Ile Gly Pro Glu Glu Asp Tyr Asp Pro Gly Tyr Phe Asn 
    290                 295                 300                 


Asn Glu Ser Asp Ile Ile Phe Gln Asp Leu Glu Lys Leu Lys Ser Arg 
305                 310                 315                 320 


Pro Ala His Leu Gly Val Phe Leu Arg Tyr Ile Phe Ser Gln Ala Asp 
                325                 330                 335     


Pro Ser Pro Leu Leu Phe Tyr Leu Cys Ala Glu Val Tyr Gln Gln Ala 
            340                 345                 350         


Ser Pro Lys Asp Ser Arg Ser Leu Gly Lys Asp Ile Trp Asn Ile Phe 
        355                 360                 365             


Leu Glu Lys Asn Ala Pro Leu Arg Val Lys Ile Pro Glu Met Leu Gln 
    370                 375                 380                 


Ala Glu Ile Asp Ser Arg Leu Arg Asn Ser Glu Asp Ala Arg Gly Val 
385                 390                 395                 400 


Leu Cys Glu Ala Gln Glu Ala Ala Met Pro Glu Ile Gln Glu Gln Ile 
                405                 410                 415     


His Asp Tyr Arg Xaa Lys Arg Xaa Leu Gly Leu Gly Ser Leu Tyr Gly 
            420                 425                 430         


Glu Asn Asp Leu Leu Asp Leu Asp Gly Asp Pro Leu Arg Glu Arg Gln 
        435                 440                 445             


Val Ala Glu Lys Gln Leu Ala Ala Leu Gly Asp Ile Leu Ser Lys Tyr 
    450                 455                 460                 


Glu Glu Asp Arg Ser Ala Pro Met Asp Phe Ala Leu Asn Xaa Tyr Met 
465                 470                 475                 480 


Ser His Ala Gly Ile Arg Leu Arg Glu Ala Arg Pro Ser Asn Xaa Ala 
                485                 490                 495     


Glu Lys Ala Gln Ser Ala Pro Asp Lys Asp Lys Trp Leu Pro Phe Phe 
            500                 505                 510         


Pro Lys Xaa Lys Lys Ser Ser Asn Ser Lys Lys Glu Lys Asp Ala Leu 
        515                 520                 525             


Glu Asp Lys Lys Arg Asn Pro Ile Leu Lys Tyr Ile Gly Lys Pro Lys 
    530                 535                 540                 


Ser Ser Ser Gln Ser Xaa Phe His Ile Pro Leu Ser Pro Val Glu Val 
545                 550                 555                 560 


Lys Pro Gly Asn Val Arg Asn Ile Ile Gln His Phe Glu Asn Asn Gln 
                565                 570                 575     


Gln Tyr Asp Ala Pro Glu Pro Gly Xaa Gln Arg Leu Ser Xaa Gly Ser 
            580                 585                 590         


Phe Pro Glu Asp Leu Leu Glu Ser Asp Ser Ser Arg Ser Glu Ile Arg 
        595                 600                 605             


Leu Gly Arg Ser Glu Ser Leu Lys Gly Arg Glu Glu Met Lys Arg Ser 
    610                 615                 620                 


Arg Lys Ala Glu Asn Val Pro Arg Ser Arg Ser Asp Val Asp Met Asp 
625                 630                 635                 640 


Ala Ala Ala Glu Ala Xaa Arg Leu His Gln Ser Ala Ser Ser Ser Xaa 
                645                 650                 655     


Ser Ser Leu Ser Xaa Arg Ser Leu Glu Asn Pro Xaa Pro Pro Phe Xaa 
            660                 665                 670         


Pro Lys Met Gly Arg Arg Ser Ile Glu Ser Pro Ser Leu Gly Phe Cys 
        675                 680                 685             


Xaa Asp Xaa Leu Leu Pro His Leu Leu Glu Asp Asp Leu Gly Gln Leu 
    690                 695                 700                 


Ser Asp Leu Glu Pro Glu Pro Asp Ala Gln Asn Trp Gln His Xaa Val 
705                 710                 715                 720 


Gly Lys Asp Val Val Ala Gly Leu Xaa Gln Arg Glu Ile Asp Arg Gln 
                725                 730                 735     


Glu Val Ile Asn Glu Leu Phe Val Xaa Glu Ala Ser His Leu Arg Xaa 
            740                 745                 750         


Leu Arg Val Leu Asp Leu Ile Phe Tyr Gln Arg Met Lys Lys Glu Asn 
        755                 760                 765             


Leu Met Pro Arg Glu Glu Leu Ala Arg Leu Phe Pro Asn Leu Pro Glu 
    770                 775                 780                 


Leu Ile Glu Ile His Asn Ser Trp Cys Glu Ala Met Lys Lys Leu Arg 
785                 790                 795                 800 


Glu Glu Gly Pro Ile Ile Lys Glu Ile Ser Asp Leu Met Leu Ala Arg 
                805                 810                 815     


Phe Asp Gly Pro Ala Arg Glu Glu Leu Gln Gln Val Ala Ala Gln Phe 
            820                 825                 830         


Cys Ser Tyr Gln Ser Ile Ala Leu Glu Leu Ile Lys Xaa Lys Gln Arg 
        835                 840                 845             


Lys Glu Ser Arg Phe Gln Leu Phe Met Gln Glu Ala Glu Ser His Pro 
    850                 855                 860                 


Gln Cys Arg Arg Leu Gln Leu Arg Asp Leu Ile Ile Ser Glu Met Gln 
865                 870                 875                 880 


Arg Leu Xaa Lys Tyr Pro Leu Leu Leu Glu Ser Ile Ile Lys His Xaa 
                885                 890                 895     


Glu Gly Gly Xaa Ser Glu His Glu Lys Leu Cys Arg Ala Arg Asp Gln 
            900                 905                 910         


Cys Arg Glu Ile Leu Lys Tyr Val Asn Glu Ala Val Lys Gln Xaa Glu 
        915                 920                 925             


Asn Arg His Arg Leu Glu Gly Tyr Gln Lys Arg Leu Asp Ala Xaa Ala 
    930                 935                 940                 


Leu Glu Arg Ala Ser Asn Pro Leu Ala Ala Glu Phe Lys Ser Leu Asp 
945                 950                 955                 960 


Leu Xaa Xaa Arg Lys Met Ile His Glu Gly Pro Leu Xaa Trp Arg Ile 
                965                 970                 975     


Ser Lys Asp Lys Xaa Leu Asp Leu His Val Leu Leu Leu Glu Asp Leu 
            980                 985                 990         


Leu Val Leu Leu Gln Lys Gln Asp  Glu Lys Leu Leu Leu  Lys Cys His 
        995                 1000                 1005             


Ser Lys  Xaa Ala Val Gly Ser  Ser Asp Ser Lys Gln  Xaa Phe Ser 
    1010                 1015                 1020             


Pro Val  Leu Lys Leu Asn Ala  Val Leu Ile Arg Ser  Val Ala Xaa 
    1025                 1030                 1035             


Asp Lys  Arg Ala Phe Phe Ile  Ile Cys Xaa Ser Lys  Leu Gly Pro 
    1040                 1045                 1050             


Pro Gln  Ile Tyr Glu Leu Val  Ala Leu Xaa Ser Ser  Asp Lys Asn 
    1055                 1060                 1065             


Xaa Trp  Met Glu Leu Leu Glu  Glu Ala Val Arg Asn  Ala Xaa Arg 
    1070                 1075                 1080             


His Pro  Gly Ala Ala Pro Met  Pro Val His Pro Pro  Pro Pro Gly 
    1085                 1090                 1095             


Pro Arg  Glu Pro Ala Gln Gln  Gly Pro Xaa Pro Ser  Arg Val Glu 
    1100                 1105                 1110             


Leu Asp  Asp Ser Asp Val Phe  His Gly Glu Pro Glu  Pro Glu Glu 
    1115                 1120                 1125             


Leu Pro  Gly Gly Xaa Gly Ser  Gln Gln Arg Val Gln  Gly Lys His 
    1130                 1135                 1140             


Gln Val  Leu Leu Glu Asp Pro  Glu Gln Glu Gly Ser  Ala Glu Glu 
    1145                 1150                 1155             


Glu Glu  Leu Gly Val Leu Pro  Cys Pro Ser Xaa Ser  Leu Asp Gly 
    1160                 1165                 1170             


Glu Asn  Arg Gly Ile Arg Xaa  Arg Asn Pro Ile His  Leu Ala Phe 
    1175                 1180                 1185             


Pro Gly  Pro Leu Phe Met Glu  Gly Leu Ala Asp Ser  Ala Leu Glu 
    1190                 1195                 1200             


Asp Val  Glu Asn Leu Arg His  Leu Ile Leu Trp Ser  Leu Leu Pro 
    1205                 1210                 1215             


Gly His  Xaa Met Glu Xaa Gln  Ala Ala Gln Glu Pro  Glu Asp Asp 
    1220                 1225                 1230             


Leu Xaa  Pro Xaa Pro Ser Val  Ile Ser Val Xaa Ser  His Pro Trp 
    1235                 1240                 1245             


Asp Pro  Gly Ser Pro Gly Gln  Ala Pro Pro Gly Gly  Glu Gly Asp 
    1250                 1255                 1260             


Asn Xaa  Gln Leu Ala Gly Leu  Glu Gly Glu Arg Pro  Glu Gln Glu 
    1265                 1270                 1275             


Asp Met  Gly Leu Cys Ser Leu  Glu His Leu Pro Pro  Arg Xaa Arg 
    1280                 1285                 1290             


Asn Ser  Gly Ile Trp Glu Ser  Pro Glu Leu Asp Arg  Asn Leu Ala 
    1295                 1300                 1305             


Glu Asp  Ala Ser Ser Xaa Glu  Ala Ala Gly Gly Tyr  Lys Val Val 
    1310                 1315                 1320             


Arg Lys  Ala Glu Val Ala Gly  Ser Lys Val Val Pro  Ala Leu Pro 
    1325                 1330                 1335             


Glu Ser  Gly Gln Ser Glu Pro  Gly Pro Pro Glu Val  Glu Gly Gly 
    1340                 1345                 1350             


Xaa Lys  Ala Xaa Gly Asn Cys  Phe Tyr Val Ser Met  Pro Ser Gly 
    1355                 1360                 1365             


Pro Pro  Asp Ser Ser Xaa Asp  His Ser Glu Ala Pro  Met Ser Pro 
    1370                 1375                 1380             


Pro Gln  Pro Asp Ser Leu Pro  Ala Gly Gln Xaa Glu  Pro Gln Pro 
    1385                 1390                 1395             


Gln Leu  Gln Gly Gly Asn Asp  Asp Pro Arg Arg Pro  Ser Arg Ser 
    1400                 1405                 1410             


Pro Pro  Ser Leu Ala Leu Arg  Asp Val Gly Met Ile  Phe His Xaa 
    1415                 1420                 1425             


Ile Glu  Gln Leu Xaa Leu Lys  Leu Asn Arg Leu Lys  Asp Met Glu 
    1430                 1435                 1440             


Leu Ala  His Arg Glu Leu Leu  Lys Ser Leu Gly Gly  Glu Ser Ser 
    1445                 1450                 1455             


Gly Gly  Xaa Xaa Pro Val Gly  Ser Phe His Xaa Glu  Ala Ala Arg 
    1460                 1465                 1470             


Trp Xaa  Asp Gly Ser Leu Ser  Pro Pro Ala Lys Glu  Pro Leu Ala 
    1475                 1480                 1485             


Ser Asp  Ser Arg Asn Ser His  Glu Leu Gly Pro Cys  Pro Glu Asp 
    1490                 1495                 1500             


Gly Ser  Asp Ala Pro Leu Glu  Asp Ser Xaa Ala Asp  Ala Ala Ala 
    1505                 1510                 1515             


Ser Pro  Gly Pro 
    1520         


<210> 2966
<211> 1562
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (983)..(983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1103)..(1103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1173)..(1173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1277)..(1277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1354)..(1354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1394)..(1394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1397)..(1397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1501)..(1502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1509)..(1509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1515)..(1515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1553)..(1553)
<223> Selenocysteine

<400> 2966
Met Ser Val Arg Leu Pro Gln Ser Ile Asp Arg Leu Ser Ser Leu Ser 
1               5                   10                  15      


Ser Leu Gly Asp Ser Ala Pro Glu Arg Lys Ser Pro Ser His His Arg 
            20                  25                  30          


Gln Pro Ser Asp Ala Ser Glu Xaa Xaa Gly Leu Val Gln Arg Cys Val 
        35                  40                  45              


Ile Ile Gln Lys Asp Gln His Gly Phe Gly Phe Xaa Val Ser Gly Asp 
    50                  55                  60                  


Arg Ile Val Leu Val Gln Ser Val Arg Pro Gly Gly Ala Ala Met Lys 
65                  70                  75                  80  


Ala Gly Val Lys Glu Gly Asp Arg Ile Ile Lys Val Asn Gly Xaa Met 
                85                  90                  95      


Val Xaa Asn Ser Ser His Leu Glu Val Val Lys Leu Ile Lys Ser Gly 
            100                 105                 110         


Ala Tyr Val Ala Leu Xaa Leu Leu Gly Ser Ser Pro Ser Ser Met Gly 
        115                 120                 125             


Ile Ser Gly Leu Gln Gln Asp Pro Ser Pro Ala Gly Ala Pro Arg Ile 
    130                 135                 140                 


Xaa Ser Val Ile Pro Ser Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro 
145                 150                 155                 160 


Gln Arg Ile Xaa Gly Pro Lys Pro Leu Gln Asp Pro Glu Val Gln Lys 
                165                 170                 175     


His Ala Xaa Gln Ile Leu Arg Asn Met Leu Arg Gln Glu Glu Lys Glu 
            180                 185                 190         


Leu Gln Arg Ile Cys Glu Val Tyr Ser Arg Asn Pro Ala Ser Leu Leu 
        195                 200                 205             


Glu Glu Gln Ile Glu Gly Ala Arg Arg Arg Val Xaa Gln Leu Gln Leu 
    210                 215                 220                 


Lys Ile Gln Gln Glu Xaa Gly Gly Ser Val Asp Ile Leu Pro Leu Tyr 
225                 230                 235                 240 


Gly Asp Xaa Ser Gln Arg Pro Ser Glu Gly Arg Leu Ser Leu Asp Ser 
                245                 250                 255     


Gln Glu Gly Asp Ser Gly Leu Asp Ser Gly Xaa Glu Arg Phe Pro Ser 
            260                 265                 270         


Leu Ser Glu Ser Leu Met Asn Arg Asn Ser Val Leu Ser Asp Pro Gly 
        275                 280                 285             


Leu Asp Ser Pro Arg Xaa Ser Pro Val Ile Met Ala Arg Val Ala Gln 
    290                 295                 300                 


His His Arg Arg Gln Gly Ser Asp Ala Ala Val Pro Ser Xaa Gly Asp 
305                 310                 315                 320 


Gln Gly Val Asp Gln Ser Pro Lys Pro Leu Ile Ile Gly Pro Glu Glu 
                325                 330                 335     


Asp Tyr Asp Pro Gly Tyr Phe Asn Asn Glu Ser Asp Ile Ile Phe Gln 
            340                 345                 350         


Asp Leu Glu Lys Leu Lys Ser Arg Pro Ala His Leu Gly Val Phe Leu 
        355                 360                 365             


Arg Tyr Ile Phe Ser Gln Ala Asp Pro Ser Pro Leu Leu Phe Tyr Leu 
    370                 375                 380                 


Cys Ala Glu Val Tyr Gln Gln Ala Ser Pro Lys Asp Ser Arg Ser Leu 
385                 390                 395                 400 


Gly Lys Asp Ile Trp Asn Ile Phe Leu Glu Lys Asn Ala Pro Leu Arg 
                405                 410                 415     


Val Lys Ile Pro Glu Met Leu Gln Ala Glu Ile Asp Ser Arg Leu Arg 
            420                 425                 430         


Asn Ser Glu Asp Ala Arg Gly Val Leu Cys Glu Ala Gln Glu Ala Ala 
        435                 440                 445             


Met Pro Glu Ile Gln Glu Gln Ile His Asp Tyr Arg Xaa Lys Arg Xaa 
    450                 455                 460                 


Leu Gly Leu Gly Ser Leu Tyr Gly Glu Asn Asp Leu Leu Asp Leu Asp 
465                 470                 475                 480 


Gly Asp Pro Leu Arg Glu Arg Gln Val Ala Glu Lys Gln Leu Ala Ala 
                485                 490                 495     


Leu Gly Asp Ile Leu Ser Lys Tyr Glu Glu Asp Arg Ser Ala Pro Met 
            500                 505                 510         


Asp Phe Ala Leu Asn Xaa Tyr Met Ser His Ala Gly Ile Arg Leu Arg 
        515                 520                 525             


Glu Ala Arg Pro Ser Asn Xaa Ala Glu Lys Ala Gln Ser Ala Pro Asp 
    530                 535                 540                 


Lys Asp Lys Trp Leu Pro Phe Phe Pro Lys Xaa Lys Lys Ser Ser Asn 
545                 550                 555                 560 


Ser Lys Lys Glu Lys Asp Ala Leu Glu Asp Lys Lys Arg Asn Pro Ile 
                565                 570                 575     


Leu Lys Tyr Ile Gly Lys Pro Lys Ser Ser Ser Gln Ser Xaa Phe His 
            580                 585                 590         


Ile Pro Leu Ser Pro Val Glu Val Lys Pro Gly Asn Val Arg Asn Ile 
        595                 600                 605             


Ile Gln His Phe Glu Asn Asn Gln Gln Tyr Asp Ala Pro Glu Pro Gly 
    610                 615                 620                 


Xaa Gln Arg Leu Ser Xaa Gly Ser Phe Pro Glu Asp Leu Leu Glu Ser 
625                 630                 635                 640 


Asp Ser Ser Arg Ser Glu Ile Arg Leu Gly Arg Ser Glu Ser Leu Lys 
                645                 650                 655     


Gly Arg Glu Glu Met Lys Arg Ser Arg Lys Ala Glu Asn Val Pro Arg 
            660                 665                 670         


Ser Arg Ser Asp Val Asp Met Asp Ala Ala Ala Glu Ala Xaa Arg Leu 
        675                 680                 685             


His Gln Ser Ala Ser Ser Ser Xaa Ser Ser Leu Ser Xaa Arg Ser Leu 
    690                 695                 700                 


Glu Asn Pro Xaa Pro Pro Phe Xaa Pro Lys Met Gly Arg Arg Ser Ile 
705                 710                 715                 720 


Glu Ser Pro Ser Leu Gly Phe Cys Xaa Asp Xaa Leu Leu Pro His Leu 
                725                 730                 735     


Leu Glu Asp Asp Leu Gly Gln Leu Ser Asp Leu Glu Pro Glu Pro Asp 
            740                 745                 750         


Ala Gln Asn Trp Gln His Xaa Val Gly Lys Asp Val Val Ala Gly Leu 
        755                 760                 765             


Xaa Gln Arg Glu Ile Asp Arg Gln Glu Val Ile Asn Glu Leu Phe Val 
    770                 775                 780                 


Xaa Glu Ala Ser His Leu Arg Xaa Leu Arg Val Leu Asp Leu Ile Phe 
785                 790                 795                 800 


Tyr Gln Arg Met Lys Lys Glu Asn Leu Met Pro Arg Glu Glu Leu Ala 
                805                 810                 815     


Arg Leu Phe Pro Asn Leu Pro Glu Leu Ile Glu Ile His Asn Ser Trp 
            820                 825                 830         


Cys Glu Ala Met Lys Lys Leu Arg Glu Glu Gly Pro Ile Ile Lys Glu 
        835                 840                 845             


Ile Ser Asp Leu Met Leu Ala Arg Phe Asp Gly Pro Ala Arg Glu Glu 
    850                 855                 860                 


Leu Gln Gln Val Ala Ala Gln Phe Cys Ser Tyr Gln Ser Ile Ala Leu 
865                 870                 875                 880 


Glu Leu Ile Lys Xaa Lys Gln Arg Lys Glu Ser Arg Phe Gln Leu Phe 
                885                 890                 895     


Met Gln Glu Ala Glu Ser His Pro Gln Cys Arg Arg Leu Gln Leu Arg 
            900                 905                 910         


Asp Leu Ile Ile Ser Glu Met Gln Arg Leu Xaa Lys Tyr Pro Leu Leu 
        915                 920                 925             


Leu Glu Ser Ile Ile Lys His Xaa Glu Gly Gly Xaa Ser Glu His Glu 
    930                 935                 940                 


Lys Leu Cys Arg Ala Arg Asp Gln Cys Arg Glu Ile Leu Lys Tyr Val 
945                 950                 955                 960 


Asn Glu Ala Val Lys Gln Xaa Glu Asn Arg His Arg Leu Glu Gly Tyr 
                965                 970                 975     


Gln Lys Arg Leu Asp Ala Xaa Ala Leu Glu Arg Ala Ser Asn Pro Leu 
            980                 985                 990         


Ala Ala Glu Phe Lys Ser Leu Asp  Leu Xaa Xaa Arg Lys  Met Ile His 
        995                 1000                 1005             


Glu Gly  Pro Leu Xaa Trp Arg  Ile Ser Lys Asp Lys  Xaa Leu Asp 
    1010                 1015                 1020             


Leu His  Val Leu Leu Leu Glu  Asp Leu Leu Val Leu  Leu Gln Lys 
    1025                 1030                 1035             


Gln Asp  Glu Lys Leu Leu Leu  Lys Cys His Ser Lys  Xaa Ala Val 
    1040                 1045                 1050             


Gly Ser  Ser Asp Ser Lys Gln  Xaa Phe Ser Pro Val  Leu Lys Leu 
    1055                 1060                 1065             


Asn Ala  Val Leu Ile Arg Ser  Val Ala Xaa Asp Lys  Arg Ala Phe 
    1070                 1075                 1080             


Phe Ile  Ile Cys Xaa Ser Lys  Leu Gly Pro Pro Gln  Ile Tyr Glu 
    1085                 1090                 1095             


Leu Val  Ala Leu Xaa Ser Ser  Asp Lys Asn Xaa Trp  Met Glu Leu 
    1100                 1105                 1110             


Leu Glu  Glu Ala Val Arg Asn  Ala Xaa Arg His Pro  Gly Ala Ala 
    1115                 1120                 1125             


Pro Met  Pro Val His Pro Pro  Pro Pro Gly Pro Arg  Glu Pro Ala 
    1130                 1135                 1140             


Gln Gln  Gly Pro Xaa Pro Ser  Arg Val Glu Leu Asp  Asp Ser Asp 
    1145                 1150                 1155             


Val Phe  His Gly Glu Pro Glu  Pro Glu Glu Leu Pro  Gly Gly Xaa 
    1160                 1165                 1170             


Gly Ser  Gln Gln Arg Val Gln  Gly Lys His Gln Val  Leu Leu Glu 
    1175                 1180                 1185             


Asp Pro  Glu Gln Glu Gly Ser  Ala Glu Glu Glu Glu  Leu Gly Val 
    1190                 1195                 1200             


Leu Pro  Cys Pro Ser Xaa Ser  Leu Asp Gly Glu Asn  Arg Gly Ile 
    1205                 1210                 1215             


Arg Xaa  Arg Asn Pro Ile His  Leu Ala Phe Pro Gly  Pro Leu Phe 
    1220                 1225                 1230             


Met Glu  Gly Leu Ala Asp Ser  Ala Leu Glu Asp Val  Glu Asn Leu 
    1235                 1240                 1245             


Arg His  Leu Ile Leu Trp Ser  Leu Leu Pro Gly His  Xaa Met Glu 
    1250                 1255                 1260             


Xaa Gln  Ala Ala Gln Glu Pro  Glu Asp Asp Leu Xaa  Pro Xaa Pro 
    1265                 1270                 1275             


Ser Val  Ile Ser Val Xaa Ser  His Pro Trp Asp Pro  Gly Ser Pro 
    1280                 1285                 1290             


Gly Gln  Ala Pro Pro Gly Gly  Glu Gly Asp Asn Xaa  Gln Leu Ala 
    1295                 1300                 1305             


Gly Leu  Glu Gly Glu Arg Pro  Glu Gln Glu Asp Met  Gly Leu Cys 
    1310                 1315                 1320             


Ser Leu  Glu His Leu Pro Pro  Arg Xaa Arg Asn Ser  Gly Ile Trp 
    1325                 1330                 1335             


Glu Ser  Pro Glu Leu Asp Arg  Asn Leu Ala Glu Asp  Ala Ser Ser 
    1340                 1345                 1350             


Xaa Glu  Ala Ala Gly Gly Tyr  Lys Val Val Arg Lys  Ala Glu Val 
    1355                 1360                 1365             


Ala Gly  Ser Lys Val Val Pro  Ala Leu Pro Glu Ser  Gly Gln Ser 
    1370                 1375                 1380             


Glu Pro  Gly Pro Pro Glu Val  Glu Gly Gly Xaa Lys  Ala Xaa Gly 
    1385                 1390                 1395             


Asn Cys  Phe Tyr Val Ser Met  Pro Ser Gly Pro Pro  Asp Ser Ser 
    1400                 1405                 1410             


Xaa Asp  His Ser Glu Ala Pro  Met Ser Pro Pro Gln  Pro Asp Ser 
    1415                 1420                 1425             


Leu Pro  Ala Gly Gln Xaa Glu  Pro Gln Pro Gln Leu  Gln Gly Gly 
    1430                 1435                 1440             


Asn Asp  Asp Pro Arg Arg Pro  Ser Arg Ser Pro Pro  Ser Leu Ala 
    1445                 1450                 1455             


Leu Arg  Asp Val Gly Met Ile  Phe His Xaa Ile Glu  Gln Leu Xaa 
    1460                 1465                 1470             


Leu Lys  Leu Asn Arg Leu Lys  Asp Met Glu Leu Ala  His Arg Glu 
    1475                 1480                 1485             


Leu Leu  Lys Ser Leu Gly Gly  Glu Ser Ser Gly Gly  Xaa Xaa Pro 
    1490                 1495                 1500             


Val Gly  Ser Phe His Xaa Glu  Ala Ala Arg Trp Xaa  Asp Gly Ser 
    1505                 1510                 1515             


Leu Ser  Pro Pro Ala Lys Glu  Pro Leu Ala Ser Asp  Ser Arg Asn 
    1520                 1525                 1530             


Ser His  Glu Leu Gly Pro Cys  Pro Glu Asp Gly Ser  Asp Ala Pro 
    1535                 1540                 1545             


Leu Glu  Asp Ser Xaa Ala Asp  Ala Ala Ala Ser Pro  Gly Pro 
    1550                 1555                 1560         


<210> 2967
<211> 1441
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1083)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1190)..(1190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1214)..(1214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1221)..(1221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1340)..(1340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1368)..(1368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1422)..(1422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<400> 2967
Met Arg Ala Gly Val Gln Xaa Gly Asp Arg Ile Ile Lys Val Asn Gly 
1               5                   10                  15      


Xaa Leu Val Xaa His Ser Asn His Leu Glu Val Val Lys Leu Ile Lys 
            20                  25                  30          


Ser Gly Ser Tyr Val Ala Leu Xaa Val Gln Gly Arg Pro Pro Gly Ser 
        35                  40                  45              


Pro Gln Ile Pro Leu Ala Asp Ser Glu Val Glu Pro Ser Val Ile Gly 
    50                  55                  60                  


His Met Ser Pro Ile Met Xaa Ser Pro His Ser Pro Gly Ala Ser Gly 
65                  70                  75                  80  


Asn Met Glu Arg Ile Xaa Ser Pro Val Leu Met Gly Glu Glu Asn Asn 
                85                  90                  95      


Val Val His Asn Gln Lys Val Glu Ile Leu Arg Lys Met Leu Gln Lys 
            100                 105                 110         


Glu Gln Glu Arg Leu Gln Leu Leu Gln Glu Asp Tyr Asn Arg Xaa Pro 
        115                 120                 125             


Ala Gln Arg Leu Leu Lys Glu Ile Gln Glu Ala Lys Lys His Ile Pro 
    130                 135                 140                 


Gln Leu Gln Glu Gln Leu Ser Lys Ala Xaa Gly Ser Ala Gln Asp Gly 
145                 150                 155                 160 


Ala Val Val Xaa Pro Ser Arg Pro Leu Gly Asp Xaa Leu Xaa Val Ser 
                165                 170                 175     


Glu Ala Glu Xaa Asp Pro Gly Asp Val Leu Gly Arg Xaa Asp Cys Ser 
            180                 185                 190         


Ser Gly Asp Ala Ser Arg Pro Ser Ser Asp Asn Ala Asp Ser Pro Lys 
        195                 200                 205             


Ser Gly Pro Lys Glu Arg Ile Tyr Leu Glu Glu Asn Pro Glu Lys Ser 
    210                 215                 220                 


Glu Xaa Ile Gln Asp Xaa Asp Xaa Gln Ser Leu Val Gly Ser Pro Ser 
225                 230                 235                 240 


Xaa Arg Ile Ala Pro His Ile Ile Gly Ala Glu Asp Asp Asp Phe Gly 
                245                 250                 255     


Xaa Glu His Glu Gln Ile Asn Gly Gln Cys Ser Cys Phe Gln Ser Ile 
            260                 265                 270         


Glu Leu Leu Lys Ser Arg Pro Ala His Leu Ala Val Phe Leu His His 
        275                 280                 285             


Val Val Ser Gln Phe Asp Pro Ala Xaa Leu Leu Cys Tyr Leu Tyr Ser 
    290                 295                 300                 


Asp Leu Tyr Lys His Xaa Asn Ser Lys Glu Xaa Arg Arg Ile Phe Leu 
305                 310                 315                 320 


Glu Phe His Gln Phe Phe Leu Asp Arg Ser Ala His Leu Lys Val Ser 
                325                 330                 335     


Val Pro Asp Glu Met Ser Ala Asp Leu Glu Lys Arg Arg Pro Glu Leu 
            340                 345                 350         


Ile Pro Glu Asp Leu His Arg His Tyr Ile Gln Xaa Met Gln Glu Arg 
        355                 360                 365             


Val His Pro Glu Val Gln Arg His Leu Glu Asp Phe Arg Gln Lys Arg 
    370                 375                 380                 


Ser Met Gly Leu Xaa Leu Ala Glu Ser Glu Leu Xaa Lys Leu Asp Ala 
385                 390                 395                 400 


Glu Arg Asp Lys Asp Arg Leu Xaa Leu Glu Lys Glu Arg Xaa Cys Ala 
                405                 410                 415     


Glu Gln Ile Val Ala Lys Ile Glu Glu Val Leu Met Xaa Ala Gln Ala 
            420                 425                 430         


Val Glu Glu Asp Lys Ser Ser Xaa Met Gln Tyr Val Ile Leu Met Tyr 
        435                 440                 445             


Met Lys His Leu Gly Val Lys Val Lys Glu Pro Arg Asn Leu Glu His 
    450                 455                 460                 


Lys Arg Gly Arg Ile Gly Phe Leu Pro Lys Ile Lys Gln Ser Met Lys 
465                 470                 475                 480 


Lys Asp Lys Glu Gly Glu Glu Lys Gly Lys Arg Arg Gly Phe Pro Ser 
                485                 490                 495     


Ile Leu Gly Pro Pro Arg Arg Pro Ser Arg His Asp Asn Ser Ala Ile 
            500                 505                 510         


Gly Arg Ala Met Glu Leu Gln Lys Ala Arg His Pro Lys His Leu Ser 
        515                 520                 525             


Xaa Pro Ser Ser Val Ser Pro Glu Pro Gln Asp Ser Ala Lys Leu Arg 
    530                 535                 540                 


Gln Ser Gly Leu Ala Asn Glu Gly Xaa Asp Ala Gly Tyr Leu Pro Ala 
545                 550                 555                 560 


Asn Ser Met Ser Ser Val Ala Ser Gly Ala Ser Phe Ser Gln Glu Gly 
                565                 570                 575     


Gly Lys Glu Asn Asp Xaa Gly Ser Lys Gln Val Gly Glu Xaa Ser Ala 
            580                 585                 590         


Pro Gly Asp Xaa Leu Asp Gly Xaa Pro Arg Xaa Leu Asn Xaa Val Phe 
        595                 600                 605             


Asp Phe Pro Pro Pro Pro Leu Asp Gln Val Gln Glu Glu Glu Cys Glu 
    610                 615                 620                 


Val Glu Arg Val Xaa Glu His Gly Xaa Pro Lys Pro Phe Arg Lys Phe 
625                 630                 635                 640 


Asp Ser Val Ala Phe Gly Glu Ser Gln Ser Glu Asp Glu Gln Phe Glu 
                645                 650                 655     


Asn Asp Leu Glu Xaa Asp Pro Pro Asn Trp Gln Gln Leu Val Ser Arg 
            660                 665                 670         


Glu Val Leu Leu Gly Leu Lys Pro Cys Glu Ile Lys Arg Gln Glu Val 
        675                 680                 685             


Ile Asn Glu Leu Phe Tyr Xaa Glu Arg Ala His Val Arg Xaa Leu Lys 
    690                 695                 700                 


Val Leu Asp Gln Val Phe Tyr Gln Arg Val Ser Arg Glu Gly Ile Leu 
705                 710                 715                 720 


Ser Pro Ser Glu Leu Arg Lys Ile Phe Ser Asn Leu Glu Asp Ile Leu 
                725                 730                 735     


Gln Leu His Ile Gly Leu Asn Glu Gln Met Lys Ala Val Arg Lys Arg 
            740                 745                 750         


Asn Glu Xaa Ser Val Ile Asp Gln Ile Gly Glu Asp Leu Leu Xaa Trp 
        755                 760                 765             


Phe Ser Gly Pro Gly Glu Glu Lys Leu Lys His Ala Ala Ala Xaa Phe 
    770                 775                 780                 


Cys Ser Asn Gln Pro Phe Ala Leu Glu Met Ile Lys Ser Arg Gln Lys 
785                 790                 795                 800 


Lys Asp Ser Arg Phe Gln Xaa Phe Val Gln Asp Ala Glu Ser Asn Pro 
                805                 810                 815     


Leu Cys Arg Arg Leu Gln Leu Lys Asp Ile Ile Pro Xaa Gln Met Gln 
            820                 825                 830         


Arg Leu Xaa Lys Tyr Pro Leu Leu Leu Asp Asn Ile Ala Lys Tyr Xaa 
        835                 840                 845             


Glu Trp Pro Xaa Glu Arg Glu Lys Val Lys Lys Ala Ala Asp His Cys 
    850                 855                 860                 


Arg Gln Ile Leu Asn Tyr Val Asn Gln Ala Val Lys Glu Ala Glu Asn 
865                 870                 875                 880 


Lys Gln Arg Leu Glu Asp Tyr Gln Arg Arg Leu Asp Xaa Ser Ser Leu 
                885                 890                 895     


Lys Leu Ser Glu Tyr Pro Asn Val Glu Glu Leu Arg Asn Leu Asp Leu 
            900                 905                 910         


Xaa Lys Arg Lys Met Ile His Glu Gly Pro Leu Val Trp Lys Val Asn 
        915                 920                 925             


Arg Asp Lys Xaa Ile Asp Leu Tyr Xaa Leu Leu Leu Glu Asp Ile Leu 
    930                 935                 940                 


Val Leu Leu Gln Lys Gln Asp Asp Arg Leu Val Leu Arg Cys His Ser 
945                 950                 955                 960 


Lys Ile Leu Ala Ser Xaa Ala Asp Ser Lys His Xaa Phe Ser Pro Val 
                965                 970                 975     


Ile Lys Leu Ser Xaa Val Leu Val Arg Gln Val Ala Xaa Asp Asn Lys 
            980                 985                 990         


Ala Leu Phe Val Ile Ser Met Ser  Asp Asn Gly Ala Gln  Ile Tyr Glu 
        995                 1000                 1005             


Leu Val  Ala Gln Xaa Val Ser  Glu Lys Xaa Val Trp  Gln Asp Leu 
    1010                 1015                 1020             


Ile Cys  Arg Met Ala Ala Ser  Val Lys Glu Gln Ser  Xaa Lys Pro 
    1025                 1030                 1035             


Ile Pro  Leu Pro Gln Ser Xaa  Pro Gly Glu Gly Asp  Asn Asp Glu 
    1040                 1045                 1050             


Glu Asp  Pro Ser Lys Leu Lys  Glu Glu Gln His Gly  Ile Ser Val 
    1055                 1060                 1065             


Xaa Gly  Leu Gln Ser Pro Asp  Arg Asp Leu Gly Leu  Glu Ser Xaa 
    1070                 1075                 1080             


Leu Ile  Ser Ser Lys Pro Gln  Ser His Ser Leu Ser  Xaa Ser Gly 
    1085                 1090                 1095             


Lys Ser  Glu Val Arg Asp Leu  Phe Val Ala Glu Arg  Gln Phe Ala 
    1100                 1105                 1110             


Lys Glu  Gln His Xaa Asp Gly  Xaa Leu Lys Glu Val  Gly Glu Asp 
    1115                 1120                 1125             


Tyr Gln  Ile Ala Ile Pro Asp  Ser His Leu Pro Val  Ser Glu Glu 
    1130                 1135                 1140             


Arg Trp  Ala Leu Asp Ala Leu  Arg Asn Leu Gly Leu  Leu Lys Gln 
    1145                 1150                 1155             


Leu Leu  Val Gln Gln Leu Gly  Leu Xaa Glu Lys Ser  Val Gln Glu 
    1160                 1165                 1170             


Asp Trp  Gln His Phe Pro Arg  Tyr Arg Xaa Ala Ser  Gln Gly Pro 
    1175                 1180                 1185             


Gln Xaa  Asp Ser Val Ile Gln  Asn Ser Glu Asn Ile  Lys Ala Tyr 
    1190                 1195                 1200             


His Ser  Gly Glu Gly His Met  Pro Phe Arg Xaa Gly  Xaa Gly Asp 
    1205                 1210                 1215             


Ile Ala  Xaa Cys Tyr Ser Pro  Arg Xaa Ser Xaa Glu  Ser Phe Ala 
    1220                 1225                 1230             


Pro Arg  Asp Ser Val Gly Leu  Ala Pro Gln Asp Ser  Gln Ala Ser 
    1235                 1240                 1245             


Asn Ile  Leu Val Met Asp His  Met Ile Met Xaa Pro  Glu Met Pro 
    1250                 1255                 1260             


Xaa Met  Glu Pro Glu Gly Gly  Leu Asp Asp Ser Gly  Glu His Phe 
    1265                 1270                 1275             


Phe Asp  Ala Arg Glu Ala His  Ser Asp Glu Asn Pro  Ser Glu Gly 
    1280                 1285                 1290             


Asp Gly  Ala Val Asn Lys Glu  Glu Lys Asp Val Asn  Leu Arg Ile 
    1295                 1300                 1305             


Ser Gly  Asn Tyr Leu Ile Leu  Asp Gly Tyr Asp Pro  Val Gln Glu 
    1310                 1315                 1320             


Ser Ser  Xaa Asp Glu Glu Val  Ala Ser Ser Leu Xaa  Leu Gln Pro 
    1325                 1330                 1335             


Met Xaa  Gly Ile Pro Ala Val  Glu Ser Xaa His Gln  Gln Gln His 
    1340                 1345                 1350             


Ser Pro  Gln Asn Xaa His Ser  Asp Gly Ala Ile Ser  Pro Phe Xaa 
    1355                 1360                 1365             


Pro Glu  Phe Leu Val Gln Gln  Arg Trp Gly Ala Met  Glu Tyr Ser 
    1370                 1375                 1380             


Cys Phe  Glu Ile Gln Ser Pro  Ser Ser Cys Ala Asp  Ser Gln Ser 
    1385                 1390                 1395             


Gln Ile  Met Glu Tyr Ile His  Lys Ile Glu Ala Asp  Leu Glu His 
    1400                 1405                 1410             


Leu Lys  Lys Val Glu Glu Ser  Tyr Xaa Ile Leu Cys  Gln Arg Leu 
    1415                 1420                 1425             


Ala Gly  Ser Ala Leu Xaa Asp  Lys His Ser Asp Lys  Ser 
    1430                 1435                 1440     


<210> 2968
<211> 1544
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (996)..(996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1221)..(1221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1224)..(1224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1270)..(1270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1293)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1317)..(1317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1319)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1324)..(1324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1330)..(1330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1367)..(1367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1429)..(1429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1438)..(1438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1443)..(1443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1451)..(1451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1461)..(1461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1471)..(1471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1525)..(1525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1537)..(1537)
<223> Selenocysteine

<400> 2968
Met Ser Gly Xaa Gln Ser Xaa Ile Xaa Asp Arg Phe Pro Leu Lys Lys 
1               5                   10                  15      


Pro Ile Arg His Gly Ser Ile Leu Asn Arg Glu Ser Pro Xaa Asp Lys 
            20                  25                  30          


Lys Gln Lys Val Glu Arg Ile Ala Ser His Asp Phe Asp Pro Xaa Asp 
        35                  40                  45              


Ser Ser Ser Lys Lys Xaa Lys Ser Ser Ser Glu Glu Ser Arg Ser Glu 
    50                  55                  60                  


Ile Tyr Gly Leu Val Gln Arg Cys Val Ile Ile Gln Lys Asp Asp Asn 
65                  70                  75                  80  


Gly Phe Gly Leu Xaa Val Ser Gly Asp Asn Pro Val Phe Val Gln Ser 
                85                  90                  95      


Val Lys Glu Asp Gly Ala Ala Met Arg Ala Gly Val Gln Xaa Gly Asp 
            100                 105                 110         


Arg Ile Ile Lys Val Asn Gly Xaa Leu Val Xaa His Ser Asn His Leu 
        115                 120                 125             


Glu Val Val Lys Leu Ile Lys Ser Gly Ser Tyr Val Ala Leu Xaa Val 
    130                 135                 140                 


Gln Gly Arg Pro Pro Gly Ser Pro Gln Ile Pro Leu Ala Asp Ser Glu 
145                 150                 155                 160 


Val Glu Pro Ser Val Ile Gly His Met Ser Pro Ile Met Xaa Ser Pro 
                165                 170                 175     


His Ser Pro Gly Ala Ser Gly Asn Met Glu Arg Ile Xaa Ser Pro Val 
            180                 185                 190         


Leu Met Gly Glu Glu Asn Asn Val Val His Asn Gln Lys Val Glu Ile 
        195                 200                 205             


Leu Arg Lys Met Leu Gln Lys Glu Gln Glu Arg Leu Gln Leu Leu Gln 
    210                 215                 220                 


Glu Asp Tyr Asn Arg Xaa Pro Ala Gln Arg Leu Leu Lys Glu Ile Gln 
225                 230                 235                 240 


Glu Ala Lys Lys His Ile Pro Gln Leu Gln Glu Gln Leu Ser Lys Ala 
                245                 250                 255     


Xaa Gly Ser Ala Gln Asp Gly Ala Val Val Xaa Pro Ser Arg Pro Leu 
            260                 265                 270         


Gly Asp Xaa Leu Xaa Val Ser Glu Ala Glu Xaa Asp Pro Gly Asp Val 
        275                 280                 285             


Leu Gly Arg Xaa Asp Cys Ser Ser Gly Asp Ala Ser Arg Pro Ser Ser 
    290                 295                 300                 


Asp Asn Ala Asp Ser Pro Lys Ser Gly Pro Lys Glu Arg Ile Tyr Leu 
305                 310                 315                 320 


Glu Glu Asn Pro Glu Lys Ser Glu Xaa Ile Gln Asp Xaa Asp Xaa Gln 
                325                 330                 335     


Ser Leu Val Gly Ser Pro Ser Xaa Arg Ile Ala Pro His Ile Ile Gly 
            340                 345                 350         


Ala Glu Asp Asp Asp Phe Gly Xaa Glu His Glu Gln Ile Asn Gly Gln 
        355                 360                 365             


Cys Ser Cys Phe Gln Ser Ile Glu Leu Leu Lys Ser Arg Pro Ala His 
    370                 375                 380                 


Leu Ala Val Phe Leu His His Val Val Ser Gln Phe Asp Pro Ala Xaa 
385                 390                 395                 400 


Leu Leu Cys Tyr Leu Tyr Ser Asp Leu Tyr Lys His Xaa Asn Ser Lys 
                405                 410                 415     


Glu Xaa Arg Arg Ile Phe Leu Glu Phe His Gln Phe Phe Leu Asp Arg 
            420                 425                 430         


Ser Ala His Leu Lys Val Ser Val Pro Asp Glu Met Ser Ala Asp Leu 
        435                 440                 445             


Glu Lys Arg Arg Pro Glu Leu Ile Pro Glu Asp Leu His Arg His Tyr 
    450                 455                 460                 


Ile Gln Xaa Met Gln Glu Arg Val His Pro Glu Val Gln Arg His Leu 
465                 470                 475                 480 


Glu Asp Phe Arg Gln Lys Arg Ser Met Gly Leu Xaa Leu Ala Glu Ser 
                485                 490                 495     


Glu Leu Xaa Lys Leu Asp Ala Glu Arg Asp Lys Asp Arg Leu Xaa Leu 
            500                 505                 510         


Glu Lys Glu Arg Xaa Cys Ala Glu Gln Ile Val Ala Lys Ile Glu Glu 
        515                 520                 525             


Val Leu Met Xaa Ala Gln Ala Val Glu Glu Asp Lys Ser Ser Xaa Met 
    530                 535                 540                 


Gln Tyr Val Ile Leu Met Tyr Met Lys His Leu Gly Val Lys Val Lys 
545                 550                 555                 560 


Glu Pro Arg Asn Leu Glu His Lys Arg Gly Arg Ile Gly Phe Leu Pro 
                565                 570                 575     


Lys Ile Lys Gln Ser Met Lys Lys Asp Lys Glu Gly Glu Glu Lys Gly 
            580                 585                 590         


Lys Arg Arg Gly Phe Pro Ser Ile Leu Gly Pro Pro Arg Arg Pro Ser 
        595                 600                 605             


Arg His Asp Asn Ser Ala Ile Gly Arg Ala Met Glu Leu Gln Lys Ala 
    610                 615                 620                 


Arg His Pro Lys His Leu Ser Xaa Pro Ser Ser Val Ser Pro Glu Pro 
625                 630                 635                 640 


Gln Asp Ser Ala Lys Leu Arg Gln Ser Gly Leu Ala Asn Glu Gly Xaa 
                645                 650                 655     


Asp Ala Gly Tyr Leu Pro Ala Asn Ser Met Ser Ser Val Ala Ser Gly 
            660                 665                 670         


Ala Ser Phe Ser Gln Glu Gly Gly Lys Glu Asn Asp Xaa Gly Ser Lys 
        675                 680                 685             


Gln Val Gly Glu Xaa Ser Ala Pro Gly Asp Xaa Leu Asp Gly Xaa Pro 
    690                 695                 700                 


Arg Xaa Leu Asn Xaa Val Phe Asp Phe Pro Pro Pro Pro Leu Asp Gln 
705                 710                 715                 720 


Val Gln Glu Glu Glu Cys Glu Val Glu Arg Val Xaa Glu His Gly Xaa 
                725                 730                 735     


Pro Lys Pro Phe Arg Lys Phe Asp Ser Val Ala Phe Gly Glu Ser Gln 
            740                 745                 750         


Ser Glu Asp Glu Gln Phe Glu Asn Asp Leu Glu Xaa Asp Pro Pro Asn 
        755                 760                 765             


Trp Gln Gln Leu Val Ser Arg Glu Val Leu Leu Gly Leu Lys Pro Cys 
    770                 775                 780                 


Glu Ile Lys Arg Gln Glu Val Ile Asn Glu Leu Phe Tyr Xaa Glu Arg 
785                 790                 795                 800 


Ala His Val Arg Xaa Leu Lys Val Leu Asp Gln Val Phe Tyr Gln Arg 
                805                 810                 815     


Val Ser Arg Glu Gly Ile Leu Ser Pro Ser Glu Leu Arg Lys Ile Phe 
            820                 825                 830         


Ser Asn Leu Glu Asp Ile Leu Gln Leu His Ile Gly Leu Asn Glu Gln 
        835                 840                 845             


Met Lys Ala Val Arg Lys Arg Asn Glu Xaa Ser Val Ile Asp Gln Ile 
    850                 855                 860                 


Gly Glu Asp Leu Leu Xaa Trp Phe Ser Gly Pro Gly Glu Glu Lys Leu 
865                 870                 875                 880 


Lys His Ala Ala Ala Xaa Phe Cys Ser Asn Gln Pro Phe Ala Leu Glu 
                885                 890                 895     


Met Ile Lys Ser Arg Gln Lys Lys Asp Ser Arg Phe Gln Xaa Phe Val 
            900                 905                 910         


Gln Asp Ala Glu Ser Asn Pro Leu Cys Arg Arg Leu Gln Leu Lys Asp 
        915                 920                 925             


Ile Ile Pro Xaa Gln Met Gln Arg Leu Xaa Lys Tyr Pro Leu Leu Leu 
    930                 935                 940                 


Asp Asn Ile Ala Lys Tyr Xaa Glu Trp Pro Xaa Glu Arg Glu Lys Val 
945                 950                 955                 960 


Lys Lys Ala Ala Asp His Cys Arg Gln Ile Leu Asn Tyr Val Asn Gln 
                965                 970                 975     


Ala Val Lys Glu Ala Glu Asn Lys Gln Arg Leu Glu Asp Tyr Gln Arg 
            980                 985                 990         


Arg Leu Asp Xaa Ser Ser Leu Lys  Leu Ser Glu Tyr Pro  Asn Val Glu 
        995                 1000                 1005             


Glu Leu  Arg Asn Leu Asp Leu  Xaa Lys Arg Lys Met  Ile His Glu 
    1010                 1015                 1020             


Gly Pro  Leu Val Trp Lys Val  Asn Arg Asp Lys Xaa  Ile Asp Leu 
    1025                 1030                 1035             


Tyr Xaa  Leu Leu Leu Glu Asp  Ile Leu Val Leu Leu  Gln Lys Gln 
    1040                 1045                 1050             


Asp Asp  Arg Leu Val Leu Arg  Cys His Ser Lys Ile  Leu Ala Ser 
    1055                 1060                 1065             


Xaa Ala  Asp Ser Lys His Xaa  Phe Ser Pro Val Ile  Lys Leu Ser 
    1070                 1075                 1080             


Xaa Val  Leu Val Arg Gln Val  Ala Xaa Asp Asn Lys  Ala Leu Phe 
    1085                 1090                 1095             


Val Ile  Ser Met Ser Asp Asn  Gly Ala Gln Ile Tyr  Glu Leu Val 
    1100                 1105                 1110             


Ala Gln  Xaa Val Ser Glu Lys  Xaa Val Trp Gln Asp  Leu Ile Cys 
    1115                 1120                 1125             


Arg Met  Ala Ala Ser Val Lys  Glu Gln Ser Xaa Lys  Pro Ile Pro 
    1130                 1135                 1140             


Leu Pro  Gln Ser Xaa Pro Gly  Glu Gly Asp Asn Asp  Glu Glu Asp 
    1145                 1150                 1155             


Pro Ser  Lys Leu Lys Glu Glu  Gln His Gly Ile Ser  Val Xaa Gly 
    1160                 1165                 1170             


Leu Gln  Ser Pro Asp Arg Asp  Leu Gly Leu Glu Ser  Xaa Leu Ile 
    1175                 1180                 1185             


Ser Ser  Lys Pro Gln Ser His  Ser Leu Ser Xaa Ser  Gly Lys Ser 
    1190                 1195                 1200             


Glu Val  Arg Asp Leu Phe Val  Ala Glu Arg Gln Phe  Ala Lys Glu 
    1205                 1210                 1215             


Gln His  Xaa Asp Gly Xaa Leu  Lys Glu Val Gly Glu  Asp Tyr Gln 
    1220                 1225                 1230             


Ile Ala  Ile Pro Asp Ser His  Leu Pro Val Ser Glu  Glu Arg Trp 
    1235                 1240                 1245             


Ala Leu  Asp Ala Leu Arg Asn  Leu Gly Leu Leu Lys  Gln Leu Leu 
    1250                 1255                 1260             


Val Gln  Gln Leu Gly Leu Xaa  Glu Lys Ser Val Gln  Glu Asp Trp 
    1265                 1270                 1275             


Gln His  Phe Pro Arg Tyr Arg  Xaa Ala Ser Gln Gly  Pro Gln Xaa 
    1280                 1285                 1290             


Asp Ser  Val Ile Gln Asn Ser  Glu Asn Ile Lys Ala  Tyr His Ser 
    1295                 1300                 1305             


Gly Glu  Gly His Met Pro Phe  Arg Xaa Gly Xaa Gly  Asp Ile Ala 
    1310                 1315                 1320             


Xaa Cys  Tyr Ser Pro Arg Xaa  Ser Xaa Glu Ser Phe  Ala Pro Arg 
    1325                 1330                 1335             


Asp Ser  Val Gly Leu Ala Pro  Gln Asp Ser Gln Ala  Ser Asn Ile 
    1340                 1345                 1350             


Leu Val  Met Asp His Met Ile  Met Xaa Pro Glu Met  Pro Xaa Met 
    1355                 1360                 1365             


Glu Pro  Glu Gly Gly Leu Asp  Asp Ser Gly Glu His  Phe Phe Asp 
    1370                 1375                 1380             


Ala Arg  Glu Ala His Ser Asp  Glu Asn Pro Ser Glu  Gly Asp Gly 
    1385                 1390                 1395             


Ala Val  Asn Lys Glu Glu Lys  Asp Val Asn Leu Arg  Ile Ser Gly 
    1400                 1405                 1410             


Asn Tyr  Leu Ile Leu Asp Gly  Tyr Asp Pro Val Gln  Glu Ser Ser 
    1415                 1420                 1425             


Xaa Asp  Glu Glu Val Ala Ser  Ser Leu Xaa Leu Gln  Pro Met Xaa 
    1430                 1435                 1440             


Gly Ile  Pro Ala Val Glu Ser  Xaa His Gln Gln Gln  His Ser Pro 
    1445                 1450                 1455             


Gln Asn  Xaa His Ser Asp Gly  Ala Ile Ser Pro Phe  Xaa Pro Glu 
    1460                 1465                 1470             


Phe Leu  Val Gln Gln Arg Trp  Gly Ala Met Glu Tyr  Ser Cys Phe 
    1475                 1480                 1485             


Glu Ile  Gln Ser Pro Ser Ser  Cys Ala Asp Ser Gln  Ser Gln Ile 
    1490                 1495                 1500             


Met Glu  Tyr Ile His Lys Ile  Glu Ala Asp Leu Glu  His Leu Lys 
    1505                 1510                 1515             


Lys Val  Glu Glu Ser Tyr Xaa  Ile Leu Cys Gln Arg  Leu Ala Gly 
    1520                 1525                 1530             


Ser Ala  Leu Xaa Asp Lys His  Ser Asp Lys Ser 
    1535                 1540                 


<210> 2969
<211> 1525
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1120)..(1120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1267)..(1267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1298)..(1298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1300)..(1300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1313)..(1313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1343)..(1343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1410)..(1410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1419)..(1419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1424)..(1424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1432)..(1432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1442)..(1442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1452)..(1452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1518)..(1518)
<223> Selenocysteine

<400> 2969
Met Ser Gly Xaa Gln Ser Xaa Ile Xaa Asp Arg Phe Pro Leu Lys Lys 
1               5                   10                  15      


Pro Ile Arg His Gly Ser Ile Leu Asn Arg Glu Ser Pro Xaa Asp Lys 
            20                  25                  30          


Lys Gln Lys Val Glu Arg Ile Ala Ser His Asp Phe Asp Pro Xaa Gly 
        35                  40                  45              


Leu Val Gln Arg Cys Val Ile Ile Gln Lys Asp Asp Asn Gly Phe Gly 
    50                  55                  60                  


Leu Xaa Val Ser Gly Asp Asn Pro Val Phe Val Gln Ser Val Lys Glu 
65                  70                  75                  80  


Asp Gly Ala Ala Met Arg Ala Gly Val Gln Xaa Gly Asp Arg Ile Ile 
                85                  90                  95      


Lys Val Asn Gly Xaa Leu Val Xaa His Ser Asn His Leu Glu Val Val 
            100                 105                 110         


Lys Leu Ile Lys Ser Gly Ser Tyr Val Ala Leu Xaa Val Gln Gly Arg 
        115                 120                 125             


Pro Pro Gly Ser Pro Gln Ile Pro Leu Ala Asp Ser Glu Val Glu Pro 
    130                 135                 140                 


Ser Val Ile Gly His Met Ser Pro Ile Met Xaa Ser Pro His Ser Pro 
145                 150                 155                 160 


Gly Ala Ser Gly Asn Met Glu Arg Ile Xaa Ser Pro Val Leu Met Gly 
                165                 170                 175     


Glu Glu Asn Asn Val Val His Asn Gln Lys Val Glu Ile Leu Arg Lys 
            180                 185                 190         


Met Leu Gln Lys Glu Gln Glu Arg Leu Gln Leu Leu Gln Glu Asp Tyr 
        195                 200                 205             


Asn Arg Xaa Pro Ala Gln Arg Leu Leu Lys Glu Ile Gln Glu Ala Lys 
    210                 215                 220                 


Lys His Ile Pro Gln Leu Gln Glu Gln Leu Ser Lys Ala Xaa Gly Ser 
225                 230                 235                 240 


Ala Gln Asp Gly Ala Val Val Xaa Pro Ser Arg Pro Leu Gly Asp Xaa 
                245                 250                 255     


Leu Xaa Val Ser Glu Ala Glu Xaa Asp Pro Gly Asp Val Leu Gly Arg 
            260                 265                 270         


Xaa Asp Cys Ser Ser Gly Asp Ala Ser Arg Pro Ser Ser Asp Asn Ala 
        275                 280                 285             


Asp Ser Pro Lys Ser Gly Pro Lys Glu Arg Ile Tyr Leu Glu Glu Asn 
    290                 295                 300                 


Pro Glu Lys Ser Glu Xaa Ile Gln Asp Xaa Asp Xaa Gln Ser Leu Val 
305                 310                 315                 320 


Gly Ser Pro Ser Xaa Arg Ile Ala Pro His Ile Ile Gly Ala Glu Asp 
                325                 330                 335     


Asp Asp Phe Gly Xaa Glu His Glu Gln Ile Asn Gly Gln Cys Ser Cys 
            340                 345                 350         


Phe Gln Ser Ile Glu Leu Leu Lys Ser Arg Pro Ala His Leu Ala Val 
        355                 360                 365             


Phe Leu His His Val Val Ser Gln Phe Asp Pro Ala Xaa Leu Leu Cys 
    370                 375                 380                 


Tyr Leu Tyr Ser Asp Leu Tyr Lys His Xaa Asn Ser Lys Glu Xaa Arg 
385                 390                 395                 400 


Arg Ile Phe Leu Glu Phe His Gln Phe Phe Leu Asp Arg Ser Ala His 
                405                 410                 415     


Leu Lys Val Ser Val Pro Asp Glu Met Ser Ala Asp Leu Glu Lys Arg 
            420                 425                 430         


Arg Pro Glu Leu Ile Pro Glu Asp Leu His Arg His Tyr Ile Gln Xaa 
        435                 440                 445             


Met Gln Glu Arg Val His Pro Glu Val Gln Arg His Leu Glu Asp Phe 
    450                 455                 460                 


Arg Gln Lys Arg Ser Met Gly Leu Xaa Leu Ala Glu Ser Glu Leu Xaa 
465                 470                 475                 480 


Lys Leu Asp Ala Glu Arg Asp Lys Asp Arg Leu Xaa Leu Glu Lys Glu 
                485                 490                 495     


Arg Xaa Cys Ala Glu Gln Ile Val Ala Lys Ile Glu Glu Val Leu Met 
            500                 505                 510         


Xaa Ala Gln Ala Val Glu Glu Asp Lys Ser Ser Xaa Met Gln Tyr Val 
        515                 520                 525             


Ile Leu Met Tyr Met Lys His Leu Gly Val Lys Val Lys Glu Pro Arg 
    530                 535                 540                 


Asn Leu Glu His Lys Arg Gly Arg Ile Gly Phe Leu Pro Lys Ile Lys 
545                 550                 555                 560 


Gln Ser Met Lys Lys Asp Lys Glu Gly Glu Glu Lys Gly Lys Arg Arg 
                565                 570                 575     


Gly Phe Pro Ser Ile Leu Gly Pro Pro Arg Arg Pro Ser Arg His Asp 
            580                 585                 590         


Asn Ser Ala Ile Gly Arg Ala Met Glu Leu Gln Lys Ala Arg His Pro 
        595                 600                 605             


Lys His Leu Ser Xaa Pro Ser Ser Val Ser Pro Glu Pro Gln Asp Ser 
    610                 615                 620                 


Ala Lys Leu Arg Gln Ser Gly Leu Ala Asn Glu Gly Xaa Asp Ala Gly 
625                 630                 635                 640 


Tyr Leu Pro Ala Asn Ser Met Ser Ser Val Ala Ser Gly Ala Ser Phe 
                645                 650                 655     


Ser Gln Glu Gly Gly Lys Glu Asn Asp Xaa Gly Ser Lys Gln Val Gly 
            660                 665                 670         


Glu Xaa Ser Ala Pro Gly Asp Xaa Leu Asp Gly Xaa Pro Arg Xaa Leu 
        675                 680                 685             


Asn Xaa Val Phe Asp Phe Pro Pro Pro Pro Leu Asp Gln Val Gln Glu 
    690                 695                 700                 


Glu Glu Cys Glu Val Glu Arg Val Xaa Glu His Gly Xaa Pro Lys Pro 
705                 710                 715                 720 


Phe Arg Lys Phe Asp Ser Val Ala Phe Gly Glu Ser Gln Ser Glu Asp 
                725                 730                 735     


Glu Gln Phe Glu Asn Asp Leu Glu Xaa Asp Pro Pro Asn Trp Gln Gln 
            740                 745                 750         


Leu Val Ser Arg Glu Val Leu Leu Gly Leu Lys Pro Cys Glu Ile Lys 
        755                 760                 765             


Arg Gln Glu Val Ile Asn Glu Leu Phe Tyr Xaa Glu Arg Ala His Val 
    770                 775                 780                 


Arg Xaa Leu Lys Val Leu Asp Gln Val Phe Tyr Gln Arg Val Ser Arg 
785                 790                 795                 800 


Glu Gly Ile Leu Ser Pro Ser Glu Leu Arg Lys Ile Phe Ser Asn Leu 
                805                 810                 815     


Glu Asp Ile Leu Gln Leu His Ile Gly Leu Asn Glu Gln Met Lys Ala 
            820                 825                 830         


Val Arg Lys Arg Asn Glu Xaa Ser Val Ile Asp Gln Ile Gly Glu Asp 
        835                 840                 845             


Leu Leu Xaa Trp Phe Ser Gly Pro Gly Glu Glu Lys Leu Lys His Ala 
    850                 855                 860                 


Ala Ala Xaa Phe Cys Ser Asn Gln Pro Phe Ala Leu Glu Met Ile Lys 
865                 870                 875                 880 


Ser Arg Gln Lys Lys Asp Ser Arg Phe Gln Xaa Phe Val Gln Asp Ala 
                885                 890                 895     


Glu Ser Asn Pro Leu Cys Arg Arg Leu Gln Leu Lys Asp Ile Ile Pro 
            900                 905                 910         


Xaa Gln Met Gln Arg Leu Xaa Lys Tyr Pro Leu Leu Leu Asp Asn Ile 
        915                 920                 925             


Ala Lys Tyr Xaa Glu Trp Pro Xaa Glu Arg Glu Lys Val Lys Lys Ala 
    930                 935                 940                 


Ala Asp His Cys Arg Gln Ile Leu Asn Tyr Val Asn Gln Ala Val Lys 
945                 950                 955                 960 


Glu Ala Glu Asn Lys Gln Arg Leu Glu Asp Tyr Gln Arg Arg Leu Asp 
                965                 970                 975     


Xaa Ser Ser Leu Lys Leu Ser Glu Tyr Pro Asn Val Glu Glu Leu Arg 
            980                 985                 990         


Asn Leu Asp Leu Xaa Lys Arg Lys  Met Ile His Glu Gly  Pro Leu Val 
        995                 1000                 1005             


Trp Lys  Val Asn Arg Asp Lys  Xaa Ile Asp Leu Tyr  Xaa Leu Leu 
    1010                 1015                 1020             


Leu Glu  Asp Ile Leu Val Leu  Leu Gln Lys Gln Asp  Asp Arg Leu 
    1025                 1030                 1035             


Val Leu  Arg Cys His Ser Lys  Ile Leu Ala Ser Xaa  Ala Asp Ser 
    1040                 1045                 1050             


Lys His  Xaa Phe Ser Pro Val  Ile Lys Leu Ser Xaa  Val Leu Val 
    1055                 1060                 1065             


Arg Gln  Val Ala Xaa Asp Asn  Lys Ala Leu Phe Val  Ile Ser Met 
    1070                 1075                 1080             


Ser Asp  Asn Gly Ala Gln Ile  Tyr Glu Leu Val Ala  Gln Xaa Val 
    1085                 1090                 1095             


Ser Glu  Lys Xaa Val Trp Gln  Asp Leu Ile Cys Arg  Met Ala Ala 
    1100                 1105                 1110             


Ser Val  Lys Glu Gln Ser Xaa  Lys Pro Ile Pro Leu  Pro Gln Ser 
    1115                 1120                 1125             


Xaa Pro  Gly Glu Gly Asp Asn  Asp Glu Glu Asp Pro  Ser Lys Leu 
    1130                 1135                 1140             


Lys Glu  Glu Gln His Gly Ile  Ser Val Xaa Gly Leu  Gln Ser Pro 
    1145                 1150                 1155             


Asp Arg  Asp Leu Gly Leu Glu  Ser Xaa Leu Ile Ser  Ser Lys Pro 
    1160                 1165                 1170             


Gln Ser  His Ser Leu Ser Xaa  Ser Gly Lys Ser Glu  Val Arg Asp 
    1175                 1180                 1185             


Leu Phe  Val Ala Glu Arg Gln  Phe Ala Lys Glu Gln  His Xaa Asp 
    1190                 1195                 1200             


Gly Xaa  Leu Lys Glu Val Gly  Glu Asp Tyr Gln Ile  Ala Ile Pro 
    1205                 1210                 1215             


Asp Ser  His Leu Pro Val Ser  Glu Glu Arg Trp Ala  Leu Asp Ala 
    1220                 1225                 1230             


Leu Arg  Asn Leu Gly Leu Leu  Lys Gln Leu Leu Val  Gln Gln Leu 
    1235                 1240                 1245             


Gly Leu  Xaa Glu Lys Ser Val  Gln Glu Asp Trp Gln  His Phe Pro 
    1250                 1255                 1260             


Arg Tyr  Arg Xaa Ala Ser Gln  Gly Pro Gln Xaa Asp  Ser Val Ile 
    1265                 1270                 1275             


Gln Asn  Ser Glu Asn Ile Lys  Ala Tyr His Ser Gly  Glu Gly His 
    1280                 1285                 1290             


Met Pro  Phe Arg Xaa Gly Xaa  Gly Asp Ile Ala Xaa  Cys Tyr Ser 
    1295                 1300                 1305             


Pro Arg  Xaa Ser Xaa Glu Ser  Phe Ala Pro Arg Asp  Ser Val Gly 
    1310                 1315                 1320             


Leu Ala  Pro Gln Asp Ser Gln  Ala Ser Asn Ile Leu  Val Met Asp 
    1325                 1330                 1335             


His Met  Ile Met Xaa Pro Glu  Met Pro Xaa Met Glu  Pro Glu Gly 
    1340                 1345                 1350             


Gly Leu  Asp Asp Ser Gly Glu  His Phe Phe Asp Ala  Arg Glu Ala 
    1355                 1360                 1365             


His Ser  Asp Glu Asn Pro Ser  Glu Gly Asp Gly Ala  Val Asn Lys 
    1370                 1375                 1380             


Glu Glu  Lys Asp Val Asn Leu  Arg Ile Ser Gly Asn  Tyr Leu Ile 
    1385                 1390                 1395             


Leu Asp  Gly Tyr Asp Pro Val  Gln Glu Ser Ser Xaa  Asp Glu Glu 
    1400                 1405                 1410             


Val Ala  Ser Ser Leu Xaa Leu  Gln Pro Met Xaa Gly  Ile Pro Ala 
    1415                 1420                 1425             


Val Glu  Ser Xaa His Gln Gln  Gln His Ser Pro Gln  Asn Xaa His 
    1430                 1435                 1440             


Ser Asp  Gly Ala Ile Ser Pro  Phe Xaa Pro Glu Phe  Leu Val Gln 
    1445                 1450                 1455             


Gln Arg  Trp Gly Ala Met Glu  Tyr Ser Cys Phe Glu  Ile Gln Ser 
    1460                 1465                 1470             


Pro Ser  Ser Cys Ala Asp Ser  Gln Ser Gln Ile Met  Glu Tyr Ile 
    1475                 1480                 1485             


His Lys  Ile Glu Ala Asp Leu  Glu His Leu Lys Lys  Val Glu Glu 
    1490                 1495                 1500             


Ser Tyr  Xaa Ile Leu Cys Gln  Arg Leu Ala Gly Ser  Ala Leu Xaa 
    1505                 1510                 1515             


Asp Lys  His Ser Asp Lys Ser  
    1520                 1525 


<210> 2970
<211> 91
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 2970
Ala Ser Pro Leu Arg Xaa Ser Arg Ser Arg Pro His Pro Pro Ser Ile 
1               5                   10                  15      


Gly His Pro Ala Val Val Leu Xaa Ser Tyr Arg Ser Xaa Ala Glu Arg 
            20                  25                  30          


Lys Leu Leu Pro Leu Leu Lys Pro Pro Lys Pro Xaa Arg Val Arg Gln 
        35                  40                  45              


Asp Ala Xaa Ile Phe Gly Asp Pro Pro Gln Pro Asp Leu Asp Leu Leu 
    50                  55                  60                  


Ser Glu Asp Gly Ile Gln Xaa Gly Asp Ser Pro Asp Glu Ala Pro Gln 
65                  70                  75                  80  


Asn Xaa Pro Pro Ala Xaa Val Glu Gly Arg Tyr 
                85                  90      


<210> 2971
<211> 116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<400> 2971
Met Ser Ala Gln Ser Leu Pro Ala Ala Xaa Pro Pro Xaa Gln Lys Pro 
1               5                   10                  15      


Pro Arg Ile Ile Arg Pro Arg Pro Pro Ser Arg Ser Arg Ala Ala Gln 
            20                  25                  30          


Ser Pro Gly Pro Pro His Asn Gly Ser Ser Pro Gln Glu Leu Pro Arg 
        35                  40                  45              


Asn Ser Asn Asp Ala Pro Xaa Pro Met Cys Xaa Pro Ile Phe Trp Glu 
    50                  55                  60                  


Pro Pro Ala Ala Ser Leu Lys Pro Pro Ala Leu Leu Pro Pro Ser Ala 
65                  70                  75                  80  


Ser Arg Ala Ser Leu Asp Ser Gln Xaa Ser Pro Asp Ser Pro Ser Ser 
                85                  90                  95      


Xaa Pro Xaa Pro Ser Pro Val Ser Arg Arg Ser Ala Ser Pro Glu Pro 
            100                 105                 110         


Ala Pro Arg Ser 
        115     


<210> 2972
<211> 208
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<400> 2972
Met Ser Ala Gln Ser Leu Pro Ala Ala Xaa Pro Pro Xaa Gln Lys Pro 
1               5                   10                  15      


Pro Arg Ile Ile Arg Pro Arg Pro Pro Ser Arg Ser Arg Ala Ala Gln 
            20                  25                  30          


Ser Pro Gly Pro Pro His Asn Gly Ser Ser Pro Gln Glu Leu Pro Arg 
        35                  40                  45              


Asn Ser Asn Asp Ala Pro Xaa Pro Met Cys Xaa Pro Ile Phe Trp Glu 
    50                  55                  60                  


Pro Pro Ala Ala Ser Leu Lys Pro Pro Ala Leu Leu Pro Pro Ser Ala 
65                  70                  75                  80  


Ser Arg Ala Ser Leu Asp Ser Gln Xaa Ser Pro Asp Ser Pro Ser Ser 
                85                  90                  95      


Xaa Pro Xaa Pro Ser Pro Val Ser Arg Arg Ser Ala Ser Pro Glu Pro 
            100                 105                 110         


Ala Pro Arg Ser Pro Val Pro Pro Pro Lys Pro Ser Gly Ser Pro Cys 
        115                 120                 125             


Xaa Pro Leu Leu Pro Met Ala Gly Val Leu Ala Gln Asn Gly Ser Ala 
    130                 135                 140                 


Ser Ala Pro Gly Xaa Val Arg Arg Leu Ala Gly Arg Phe Glu Gly Gly 
145                 150                 155                 160 


Ala Glu Gly Arg Ala Gln Asp Ala Asp Ala Pro Glu Pro Gly Leu Gln 
                165                 170                 175     


Ala Arg Ala Asp Val Asn Gly Glu Arg Glu Ala Pro Leu Xaa Gly Ser 
            180                 185                 190         


Gly Ser Gln Glu Asn Gly Ala Pro Asp Ala Gly Leu Ala Cys Pro Pro 
        195                 200                 205             


<210> 2973
<211> 841
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<400> 2973
Met Ser Ala Gln Ser Leu Pro Ala Ala Xaa Pro Pro Xaa Gln Lys Pro 
1               5                   10                  15      


Pro Arg Ile Ile Arg Pro Arg Pro Pro Ser Arg Ser Arg Ala Ala Gln 
            20                  25                  30          


Ser Pro Gly Pro Pro His Asn Gly Ser Ser Pro Gln Glu Leu Pro Arg 
        35                  40                  45              


Asn Ser Asn Asp Ala Pro Xaa Pro Met Cys Xaa Pro Ile Phe Trp Glu 
    50                  55                  60                  


Pro Pro Ala Ala Ser Leu Lys Pro Pro Ala Leu Leu Pro Pro Ser Ala 
65                  70                  75                  80  


Ser Arg Ala Ser Leu Asp Ser Gln Xaa Ser Pro Asp Ser Pro Ser Ser 
                85                  90                  95      


Xaa Pro Xaa Pro Ser Pro Val Ser Arg Arg Ser Ala Ser Pro Glu Pro 
            100                 105                 110         


Ala Pro Arg Ser Pro Val Pro Pro Pro Lys Pro Ser Gly Ser Pro Cys 
        115                 120                 125             


Xaa Pro Leu Leu Pro Met Ala Gly Val Leu Ala Gln Asn Gly Ser Ala 
    130                 135                 140                 


Ser Ala Pro Gly Xaa Val Arg Arg Leu Ala Gly Arg Phe Glu Gly Gly 
145                 150                 155                 160 


Ala Glu Gly Arg Ala Gln Asp Ala Asp Ala Pro Glu Pro Gly Leu Gln 
                165                 170                 175     


Ala Arg Ala Asp Val Asn Gly Glu Arg Glu Ala Pro Leu Xaa Gly Ser 
            180                 185                 190         


Gly Ser Gln Glu Asn Gly Ala Pro Asp Ala Gly Leu Ala Cys Pro Pro 
        195                 200                 205             


Cys Cys Pro Cys Val Cys His Xaa Xaa Arg Pro Gly Leu Glu Leu Arg 
    210                 215                 220                 


Trp Val Pro Val Gly Gly Tyr Glu Glu Val Pro Arg Val Pro Arg Arg 
225                 230                 235                 240 


Ala Ser Pro Leu Arg Xaa Ser Arg Ser Arg Pro His Pro Pro Ser Ile 
                245                 250                 255     


Gly His Pro Ala Val Val Leu Xaa Ser Tyr Arg Ser Xaa Ala Glu Arg 
            260                 265                 270         


Lys Leu Leu Pro Leu Leu Lys Pro Pro Lys Pro Xaa Arg Val Arg Gln 
        275                 280                 285             


Asp Ala Xaa Ile Phe Gly Asp Pro Pro Gln Pro Asp Leu Asp Leu Leu 
    290                 295                 300                 


Ser Glu Asp Gly Ile Gln Xaa Gly Asp Ser Pro Asp Glu Ala Pro Gln 
305                 310                 315                 320 


Asn Xaa Pro Pro Ala Xaa Val Glu Gly Arg Glu Glu Glu Gly Leu Glu 
                325                 330                 335     


Val Leu Lys Glu Gln Asn Trp Glu Leu Pro Leu Gln Asp Glu Pro Leu 
            340                 345                 350         


Tyr Gln Xaa Tyr Arg Ala Ala Val Leu Ser Glu Glu Leu Trp Gly Val 
        355                 360                 365             


Gly Glu Asp Gly Ser Pro Ser Pro Ala Asn Ala Gly Asp Ala Pro Xaa 
    370                 375                 380                 


Phe Pro Arg Pro Pro Gly Pro Arg Asn Xaa Leu Trp Gln Glu Leu Pro 
385                 390                 395                 400 


Ala Val Gln Ala Ser Gly Leu Leu Asp Xaa Leu Ser Pro Gln Glu Arg 
                405                 410                 415     


Arg Met Gln Glu Ser Leu Phe Glu Val Val Xaa Ser Glu Ala Ser Tyr 
            420                 425                 430         


Leu Arg Ser Leu Arg Leu Leu Xaa Asp Xaa Phe Val Leu Ser Gln Ala 
        435                 440                 445             


Leu Arg Asp Xaa Leu Xaa Pro Arg Asp His His Xaa Leu Phe Ser Asn 
    450                 455                 460                 


Val Gln Arg Val Gln Gly Val Ser Glu Arg Phe Leu Ala Xaa Leu Leu 
465                 470                 475                 480 


Ser Arg Val Arg Ser Ser Pro His Ile Ser Asp Leu Cys Asp Val Val 
                485                 490                 495     


His Ala His Ala Val Gly Pro Phe Ser Val Tyr Val Asp Tyr Val Arg 
            500                 505                 510         


Asn Gln Gln Tyr Gln Glu Glu Xaa Tyr Ser Arg Leu Met Asp Xaa Asn 
        515                 520                 525             


Val Arg Phe Ser Ala Glu Leu Arg Arg Leu Gln Ser Leu Pro Lys Cys 
    530                 535                 540                 


Glu Arg Leu Pro Leu Pro Ser Phe Leu Leu Leu Pro Phe Gln Arg Ile 
545                 550                 555                 560 


Xaa Arg Leu Arg Met Leu Leu Gln Asn Ile Leu Arg Gln Xaa Glu Glu 
                565                 570                 575     


Gly Ser Ser Arg Gln Glu Asn Ala Gln Lys Ala Leu Gly Ala Val Ser 
            580                 585                 590         


Lys Ile Ile Glu Arg Cys Ser Ala Glu Val Gly Arg Met Lys Gln Xaa 
        595                 600                 605             


Glu Glu Leu Ile Arg Leu Xaa Gln Arg Leu Arg Phe His Lys Val Lys 
    610                 615                 620                 


Ala Leu Pro Leu Val Ser Trp Ser Arg Arg Leu Glu Phe Gln Gly Glu 
625                 630                 635                 640 


Leu Xaa Glu Leu Gly Cys Arg Arg Gly Gly Val Leu Phe Ala Ser Arg 
                645                 650                 655     


Pro Arg Phe Xaa Pro Leu Cys Leu Leu Leu Phe Ser Asp Leu Leu Leu 
            660                 665                 670         


Ile Xaa Gln Pro Lys Ser Gly Gln Arg Leu Gln Val Leu Asp Tyr Ala 
        675                 680                 685             


His Arg Ser Leu Val Gln Ala Gln Gln Val Pro Asp Pro Ser Gly Pro 
    690                 695                 700                 


Pro Xaa Phe Arg Leu Ser Leu Leu Ser Asn His Gln Gly Arg Pro Xaa 
705                 710                 715                 720 


His Arg Leu Leu Gln Ala Ser Ser Leu Ser Asp Met Gln Arg Trp Leu 
                725                 730                 735     


Gly Ala Phe Pro Xaa Pro Gly Pro Leu Pro Cys Ser Pro Asp Xaa Ile 
            740                 745                 750         


Tyr Glu Asp Cys Asp Cys Ser Gln Glu Leu Cys Ser Glu Ser Ser Ala 
        755                 760                 765             


Pro Ala Lys Xaa Glu Gly Arg Ser Leu Glu Ser Arg Ala Ala Pro Lys 
    770                 775                 780                 


His Leu His Lys Xaa Pro Glu Gly Trp Leu Lys Gly Leu Pro Gly Ala 
785                 790                 795                 800 


Phe Pro Ala Gln Leu Val Cys Glu Val Xaa Gly Glu His Glu Arg Arg 
                805                 810                 815     


Arg His Leu Arg Gln Asn Gln Arg Leu Leu Glu Ala Val Gly Ser Ser 
            820                 825                 830         


Ser Gly Xaa Pro Asn Ala Pro Pro Pro 
        835                 840     


<210> 2974
<211> 709
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<400> 2974
Met Ala Gln Arg His Ser Asp Ser Ser Leu Glu Glu Lys Leu Leu Gly 
1               5                   10                  15      


His Arg Phe His Ser Glu Leu Arg Leu Asp Ala Gly Gly Asn Pro Ala 
            20                  25                  30          


Ser Gly Leu Pro Met Val Arg Gly Ser Pro Arg Val Arg Asp Asp Ala 
        35                  40                  45              


Ala Phe Gln Pro Gln Val Pro Ala Pro Pro Gln Pro Arg Pro Pro Gly 
    50                  55                  60                  


His Glu Glu Pro Trp Pro Ile Val Leu Ser Xaa Glu Ser Pro Ala Ala 
65                  70                  75                  80  


Leu Lys Leu Gly Xaa Gln Gln Leu Ile Pro Lys Ser Leu Ala Val Ala 
                85                  90                  95      


Ser Lys Ala Lys Xaa Pro Ala Arg His Gln Ser Phe Gly Ala Ala Val 
            100                 105                 110         


Leu Ser Arg Glu Ala Ala Arg Arg Asp Pro Lys Leu Leu Pro Ala Pro 
        115                 120                 125             


Ser Phe Ser Leu Asp Asp Met Asp Val Asp Lys Asp Pro Gly Gly Met 
    130                 135                 140                 


Leu Arg Arg Asn Leu Arg Asn Gln Ser Tyr Arg Ala Ala Met Lys Gly 
145                 150                 155                 160 


Leu Gly Lys Pro Gly Gly Gln Gly Asp Ala Ile Gln Leu Ser Pro Lys 
                165                 170                 175     


Leu Gln Ala Leu Ala Glu Glu Pro Ser Gln Pro His Xaa Arg Ser Pro 
            180                 185                 190         


Ala Lys Asn Lys Lys Xaa Leu Gly Arg Lys Arg Gly His Lys Gly Ser 
        195                 200                 205             


Phe Lys Asp Asp Pro Gln Leu Tyr Gln Glu Ile Gln Glu Arg Gly Leu 
    210                 215                 220                 


Asn Xaa Ser Gln Glu Ser Asp Asp Asp Ile Leu Asp Glu Ser Ser Ser 
225                 230                 235                 240 


Pro Glu Gly Xaa Gln Lys Val Asp Ala Xaa Ile Val Val Lys Ser Tyr 
                245                 250                 255     


Arg Pro Ala Gln Val Xaa Trp Ser Gln Leu Pro Glu Val Val Glu Leu 
            260                 265                 270         


Gly Ile Leu Asp Gln Leu Ser Xaa Glu Glu Arg Lys Arg Gln Glu Ala 
        275                 280                 285             


Met Phe Glu Ile Leu Xaa Ser Glu Phe Ser Tyr Gln His Ser Leu Ser 
    290                 295                 300                 


Ile Leu Val Glu Glu Phe Leu Gln Ser Lys Glu Leu Arg Ala Xaa Val 
305                 310                 315                 320 


Xaa Gln Met Glu His His His Leu Phe Ser Asn Ile Leu Asp Val Leu 
                325                 330                 335     


Gly Ala Ser Gln Arg Phe Phe Glu Asp Leu Glu Gln Arg His Lys Ala 
            340                 345                 350         


Gln Val Leu Val Glu Asp Ile Ser Asp Ile Leu Glu Glu His Ala Glu 
        355                 360                 365             


Lys His Phe His Pro Tyr Ile Ala Tyr Cys Ser Asn Glu Val Tyr Gln 
    370                 375                 380                 


Gln Arg Xaa Leu Gln Lys Leu Ile Ser Ser Asn Ala Ala Phe Arg Glu 
385                 390                 395                 400 


Ala Leu Arg Glu Ile Glu Arg Arg Pro Ala Cys Gly Gly Leu Pro Met 
                405                 410                 415     


Leu Ser Phe Leu Ile Leu Pro Met Gln Arg Val Xaa Arg Leu Pro Leu 
            420                 425                 430         


Leu Met Asp Xaa Leu Cys Leu Lys Xaa Gln Gly His Ser Glu Arg Tyr 
        435                 440                 445             


Lys Ala Ala Ser Arg Ala Leu Lys Ala Ile Ser Lys Leu Val Arg Gln 
    450                 455                 460                 


Cys Asn Glu Gly Ala His Arg Met Glu Arg Met Glu Gln Met Tyr Xaa 
465                 470                 475                 480 


Leu His Xaa Gln Leu Asp Phe Ser Lys Val Lys Ser Leu Pro Leu Ile 
                485                 490                 495     


Ser Ala Ser Arg Trp Leu Leu Lys Arg Gly Glu Leu Phe Leu Val Glu 
            500                 505                 510         


Glu Xaa Gly Leu Phe Arg Lys Ile Ala Ser Arg Pro Xaa Cys Tyr Leu 
        515                 520                 525             


Phe Leu Phe Asn Asp Val Leu Val Val Xaa Lys Lys Lys Ser Glu Glu 
    530                 535                 540                 


Ser Tyr Met Val Gln Asp Tyr Ala Gln Met Asn His Ile Gln Val Glu 
545                 550                 555                 560 


Lys Ile Glu Pro Ser Glu Leu Pro Leu Pro Gly Gly Gly Asn Arg Ser 
                565                 570                 575     


Ser Ser Val Pro His Pro Phe Gln Val Xaa Leu Leu Arg Asn Ser Glu 
            580                 585                 590         


Gly Arg Gln Glu Gln Leu Leu Leu Ser Ser Asp Ser Ala Ser Asp Arg 
        595                 600                 605             


Ala Arg Trp Ile Val Ala Leu Xaa His Ser Glu Arg Gln Trp Gln Gly 
    610                 615                 620                 


Leu Ser Ser Lys Gly Asp Leu Pro Gln Val Glu Ile Xaa Lys Ala Phe 
625                 630                 635                 640 


Phe Ala Lys Gln Ala Asp Glu Val Xaa Leu Gln Gln Ala Asp Val Val 
                645                 650                 655     


Leu Val Leu Gln Gln Glu Asp Gly Trp Leu Tyr Gly Glu Arg Leu Arg 
            660                 665                 670         


Asp Gly Glu Xaa Gly Trp Phe Pro Glu Asp Phe Ala Arg Phe Ile Xaa 
        675                 680                 685             


Ser Arg Val Ala Val Glu Gly Asn Val Arg Arg Met Glu Arg Leu Arg 
    690                 695                 700                 


Val Glu Xaa Asp Val 
705                 


<210> 2975
<211> 180
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<400> 2975
Met Phe Ala Ser Asp Leu Leu Arg Ala Leu Asp Cys Cys Pro Gly Ala 
1               5                   10                  15      


Gly Ser Ser Gly Leu Leu Pro Gln Leu Gly Pro Arg Gln Leu Leu Ala 
            20                  25                  30          


Phe Xaa Val Asn Cys Leu Gly Asn His Arg Tyr Leu Gly Phe Phe Glu 
        35                  40                  45              


Asp Leu Glu Gln Arg His Lys Ala Gln Val Leu Val Glu Asp Ile Ser 
    50                  55                  60                  


Asp Ile Leu Glu Glu His Ala Glu Lys His Phe His Pro Tyr Ile Ala 
65                  70                  75                  80  


Tyr Cys Ser Asn Glu Val Tyr Gln Gln Arg Xaa Leu Gln Lys Leu Ile 
                85                  90                  95      


Ser Ser Asn Ala Ala Phe Arg Glu Ala Leu Arg Glu Ile Glu Arg Arg 
            100                 105                 110         


Pro Ala Cys Gly Gly Leu Pro Met Leu Ser Phe Leu Ile Leu Pro Met 
        115                 120                 125             


Gln Arg Val Xaa Arg Leu Pro Leu Leu Met Asp Xaa Leu Cys Leu Lys 
    130                 135                 140                 


Xaa Gln Gly His Ser Glu Arg Tyr Lys Ala Ala Ser Arg Ala Leu Lys 
145                 150                 155                 160 


Ala Ile Ser Lys Leu Val Arg Gln Cys Asn Glu Gly Ala His Arg Met 
                165                 170                 175     


Glu Arg Met Glu 
            180 


<210> 2976
<211> 146
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<400> 2976
Met Phe Glu Ile Leu Xaa Ser Glu Phe Ser Tyr Gln His Ser Leu Ser 
1               5                   10                  15      


Ile Leu Val Glu Glu Phe Leu Gln Ser Lys Glu Leu Arg Ala Xaa Val 
            20                  25                  30          


Xaa Gln Met Glu His His His Leu Phe Ser Asn Ile Leu Asp Val Leu 
        35                  40                  45              


Gly Ala Ser Gln Arg Phe Phe Glu Asp Leu Glu Gln Arg His Lys Ala 
    50                  55                  60                  


Gln Val Leu Val Glu Asp Ile Ser Asp Ile Leu Glu Glu His Ala Glu 
65                  70                  75                  80  


Lys His Phe His Pro Tyr Ile Ala Tyr Cys Ser Asn Glu Val Tyr Gln 
                85                  90                  95      


Gln Arg Xaa Leu Gln Lys Leu Ile Ser Ser Asn Ala Ala Phe Arg Glu 
            100                 105                 110         


Ala Leu Arg Glu Ile Glu Arg Arg Pro Ala Cys Gly Gly Leu Pro Met 
        115                 120                 125             


Leu Ser Phe Leu Ile Leu Pro Met Gln Arg Val Xaa Arg Leu Pro Leu 
    130                 135                 140                 


Leu Met 
145     


<210> 2977
<211> 421
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<400> 2977
Met Phe Glu Ile Leu Xaa Ser Glu Phe Ser Tyr Gln His Ser Leu Ser 
1               5                   10                  15      


Ile Leu Val Glu Glu Phe Leu Gln Ser Lys Glu Leu Arg Ala Xaa Val 
            20                  25                  30          


Xaa Gln Met Glu His His His Leu Phe Ser Asn Ile Leu Asp Val Leu 
        35                  40                  45              


Gly Ala Ser Gln Arg Phe Phe Glu Asp Leu Glu Gln Arg His Lys Ala 
    50                  55                  60                  


Gln Val Leu Val Glu Asp Ile Ser Asp Ile Leu Glu Glu His Ala Glu 
65                  70                  75                  80  


Lys His Phe His Pro Tyr Ile Ala Tyr Cys Ser Asn Glu Val Tyr Gln 
                85                  90                  95      


Gln Arg Xaa Leu Gln Lys Leu Ile Ser Ser Asn Ala Ala Phe Arg Glu 
            100                 105                 110         


Ala Leu Arg Glu Ile Glu Arg Arg Pro Ala Cys Gly Gly Leu Pro Met 
        115                 120                 125             


Leu Ser Phe Leu Ile Leu Pro Met Gln Arg Val Xaa Arg Leu Pro Leu 
    130                 135                 140                 


Leu Met Asp Xaa Leu Cys Leu Lys Xaa Gln Gly His Ser Glu Arg Tyr 
145                 150                 155                 160 


Lys Ala Ala Ser Arg Ala Leu Lys Ala Ile Ser Lys Leu Val Arg Gln 
                165                 170                 175     


Cys Asn Glu Gly Ala His Arg Met Glu Arg Met Glu Gln Met Tyr Xaa 
            180                 185                 190         


Leu His Xaa Gln Leu Asp Phe Ser Lys Val Lys Ser Leu Pro Leu Ile 
        195                 200                 205             


Ser Ala Ser Arg Trp Leu Leu Lys Arg Gly Glu Leu Phe Leu Val Glu 
    210                 215                 220                 


Glu Xaa Gly Leu Phe Arg Lys Ile Ala Ser Arg Pro Xaa Cys Tyr Leu 
225                 230                 235                 240 


Phe Leu Phe Asn Asp Val Leu Val Val Xaa Lys Lys Lys Ser Glu Glu 
                245                 250                 255     


Ser Tyr Met Val Gln Asp Tyr Ala Gln Met Asn His Ile Gln Val Glu 
            260                 265                 270         


Lys Ile Glu Pro Ser Glu Leu Pro Leu Pro Gly Gly Gly Asn Arg Ser 
        275                 280                 285             


Ser Ser Val Pro His Pro Phe Gln Val Xaa Leu Leu Arg Asn Ser Glu 
    290                 295                 300                 


Gly Arg Gln Glu Gln Leu Leu Leu Ser Ser Asp Ser Ala Ser Asp Arg 
305                 310                 315                 320 


Ala Arg Trp Ile Val Ala Leu Xaa His Ser Glu Arg Gln Trp Gln Gly 
                325                 330                 335     


Leu Ser Ser Lys Gly Asp Leu Pro Gln Val Glu Ile Xaa Lys Ala Phe 
            340                 345                 350         


Phe Ala Lys Gln Ala Asp Glu Val Xaa Leu Gln Gln Ala Asp Val Val 
        355                 360                 365             


Leu Val Leu Gln Gln Glu Asp Gly Trp Leu Tyr Gly Glu Arg Leu Arg 
    370                 375                 380                 


Asp Gly Glu Xaa Gly Trp Phe Pro Glu Asp Phe Ala Arg Phe Ile Xaa 
385                 390                 395                 400 


Ser Arg Val Ala Val Glu Gly Asn Val Arg Arg Met Glu Arg Leu Arg 
                405                 410                 415     


Val Glu Xaa Asp Val 
            420     


<210> 2978
<211> 2063
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1007)..(1007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1343)..(1343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1368)..(1368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1493)..(1493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1505)..(1505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1577)..(1577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1598)..(1598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1620)..(1620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1650)..(1650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1659)..(1659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1669)..(1669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1676)..(1676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1679)..(1680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1705)..(1705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1722)..(1722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1745)..(1745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1775)..(1775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1813)..(1813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1816)..(1816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1822)..(1822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1846)..(1846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1876)..(1876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1890)..(1890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1900)..(1900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1925)..(1925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1938)..(1938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1945)..(1945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1948)..(1948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1952)..(1952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1963)..(1963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1970)..(1970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1991)..(1991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1998)..(1998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2048)..(2048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2055)..(2055)
<223> Selenocysteine

<400> 2978
Met Ala Asp Gly Ala Pro Arg Pro Gln Leu Tyr Arg Ser Val Ser Phe 
1               5                   10                  15      


Lys Leu Leu Glu Arg Trp Ser Gly Gly Pro Gly Leu Arg Glu Glu Asp 
            20                  25                  30          


Xaa Asp Xaa Pro Gly Leu Arg Arg Arg Ala Ser Cys Arg Pro Xaa Xaa 
        35                  40                  45              


Ala Ala Arg Gly Gln Pro Ser Arg Arg Val Ser Lys Leu Ala Ser Gly 
    50                  55                  60                  


Pro Leu Ala Ala Pro Ala Gln Pro Arg Pro Leu Arg Ser Leu Ser Pro 
65                  70                  75                  80  


Ser Val Arg Gln Leu Ser Arg Arg Phe Asp Ala Pro Arg Leu Asp Asp 
                85                  90                  95      


Gly Ser Ala Gly Xaa Arg Asp Gly Gly Val Leu Pro Ala Ala Ala Glu 
            100                 105                 110         


Glu Ala Ala Glu Gly Pro Ala Arg Gly Ala Trp Pro Ser Val Xaa Glu 
        115                 120                 125             


Met Arg Lys Leu Phe Gly Gly Pro Gly Ser Arg Arg Pro Ser Ala Asp 
    130                 135                 140                 


Ser Glu Ser Pro Gly Xaa Pro Ser Pro Asp Gly Ala Ala Trp Glu Pro 
145                 150                 155                 160 


Pro Ala Arg Glu Ser Arg Gln Pro Pro Xaa Pro Pro Pro Arg Xaa Cys 
                165                 170                 175     


Phe Pro Leu Ala Gly Leu Arg Ser Ala Arg Pro Leu Xaa Gly Pro Glu 
            180                 185                 190         


Xaa Glu Gly Arg Leu Arg Arg Pro Gln Gln Gln Gln Glu Arg Ala Gln 
        195                 200                 205             


Arg Pro Ala Asp Gly Leu His Ser Trp His Ile Phe Ser Gln Pro Gln 
    210                 215                 220                 


Ala Gly Ala Arg Ala Ser Cys Ser Ser Ser Ser Ile Ala Ala Ser Tyr 
225                 230                 235                 240 


Pro Val Ser Arg Ser Arg Ala Ala Ser Ser Ser Glu Glu Glu Glu Glu 
                245                 250                 255     


Gly Pro Pro Gln Leu Pro Gly Ala Gln Ser Pro Ala Tyr His Gly Gly 
            260                 265                 270         


His Ser Ser Gly Ser Asp Asp Asp Arg Asp Gly Glu Gly Gly His Arg 
        275                 280                 285             


Trp Gly Gly Arg Pro Gly Leu Arg Pro Gly Ser Ser Leu Leu Asp Gln 
    290                 295                 300                 


Asp Cys Arg Pro Asp Ser Asp Gly Leu Asn Leu Ser Ser Met Asn Ser 
305                 310                 315                 320 


Ala Gly Val Ser Gly Ser Pro Glu Pro Pro Xaa Ser Pro Arg Ala Pro 
                325                 330                 335     


Arg Glu Glu Gly Leu Arg Glu Trp Gly Ser Gly Ser Pro Pro Cys Val 
            340                 345                 350         


Pro Gly Pro Gln Glu Gly Leu Arg Pro Met Ser Asp Ser Val Gly Gly 
        355                 360                 365             


Ala Phe Arg Val Ala Lys Val Ser Phe Pro Ser Tyr Leu Ala Ser Pro 
    370                 375                 380                 


Ala Gly Ser Arg Gly Ser Ser Arg Tyr Ser Ser Xaa Glu Xaa Leu Lys 
385                 390                 395                 400 


Asp Asp Asp Leu Trp Ser Ser Arg Gly Ser Gly Gly Trp Gly Val Tyr 
                405                 410                 415     


Arg Ser Pro Ser Phe Gly Ala Gly Glu Gly Leu Leu Arg Ser Gln Ala 
            420                 425                 430         


Arg Xaa Arg Ala Lys Gly Pro Gly Gly Xaa Ser Arg Ala Leu Arg Asp 
        435                 440                 445             


Gly Gly Phe Glu Pro Glu Lys Ser Arg Gln Arg Lys Ser Leu Ser Asn 
    450                 455                 460                 


Pro Asp Ile Ala Ser Glu Xaa Leu Xaa Leu Leu Ser Phe Leu Arg Ser 
465                 470                 475                 480 


Asp Leu Ser Glu Leu Arg Val Arg Lys Pro Gly Gly Ser Ser Gly Asp 
                485                 490                 495     


Arg Gly Ser Asn Pro Leu Asp Gly Arg Asp Ser Pro Ser Ala Gly Gly 
            500                 505                 510         


Pro Val Gly Gln Leu Glu Pro Ile Pro Ile Pro Ala Pro Ala Ser Pro 
        515                 520                 525             


Gly Xaa Arg Pro Xaa Leu Lys Asp Leu Xaa Ala Xaa Leu Arg Arg Ala 
    530                 535                 540                 


Lys Ser Phe Xaa Cys Ser Glu Lys Pro Met Ala Arg Arg Leu Pro Arg 
545                 550                 555                 560 


Xaa Ser Ala Leu Lys Ser Ser Ser Ser Glu Leu Leu Leu Xaa Gly Pro 
                565                 570                 575     


Gly Ala Glu Glu Asp Pro Leu Pro Leu Ile Val Gln Asp Gln Tyr Val 
            580                 585                 590         


Gln Glu Ala Arg Gln Val Phe Glu Lys Ile Gln Arg Met Gly Ala Gln 
        595                 600                 605             


Gln Asp Asp Gly Ser Asp Ala Pro Pro Gly Ser Pro Asp Trp Ala Gly 
    610                 615                 620                 


Asp Val Xaa Arg Gly Gln Arg Ser Gln Glu Glu Leu Ser Gly Pro Glu 
625                 630                 635                 640 


Ser Ser Leu Xaa Asp Glu Gly Ile Gly Ala Asp Pro Glu Pro Pro Val 
                645                 650                 655     


Ala Ala Phe Cys Gly Leu Gly Xaa Xaa Gly Met Trp Arg Pro Leu Ser 
            660                 665                 670         


Ser Ser Ser Ala Gln Xaa Asn His His Gly Pro Gly Xaa Glu Asp Ser 
        675                 680                 685             


Leu Gly Gly Trp Ala Leu Val Ser Pro Glu Xaa Pro Pro Xaa Pro Gly 
    690                 695                 700                 


Ala Leu Arg Arg Arg Arg Lys Val Pro Pro Ser Gly Ser Gly Gly Ser 
705                 710                 715                 720 


Glu Leu Ser Asn Gly Glu Ala Gly Glu Ala Tyr Arg Ser Leu Ser Asp 
                725                 730                 735     


Pro Ile Pro Gln Arg His Arg Ala Ala Xaa Ser Glu Glu Pro Xaa Gly 
            740                 745                 750         


Phe Ser Val Asp Ser Asn Leu Leu Gly Ser Leu Ser Pro Lys Xaa Gly 
        755                 760                 765             


Leu Pro Ala Xaa Ser Ala Met Asp Glu Gly Leu Xaa Ser Gly His Ser 
    770                 775                 780                 


Asp Trp Ser Val Gly Ser Glu Glu Ser Lys Gly Tyr Gln Glu Val Ile 
785                 790                 795                 800 


Gln Ser Ile Val Gln Gly Pro Gly Xaa Leu Gly Arg Val Val Asp Asp 
                805                 810                 815     


Arg Ile Ala Gly Lys Ala Pro Lys Lys Lys Ser Leu Ser Asp Pro Ser 
            820                 825                 830         


Arg Arg Gly Glu Leu Ala Gly Pro Gly Phe Glu Gly Pro Gly Gly Glu 
        835                 840                 845             


Pro Ile Arg Glu Val Glu Pro Met Leu Pro Pro Ser Ser Ser Glu Pro 
    850                 855                 860                 


Ile Leu Val Glu Gln Arg Ala Glu Pro Glu Glu Pro Gly Ala Xaa Arg 
865                 870                 875                 880 


Ser Arg Ala Gln Ser Glu Arg Ala Leu Pro Glu Ala Leu Pro Pro Pro 
                885                 890                 895     


Ala Xaa Ala His Arg Asn Phe His Leu Asp Pro Lys Leu Ala Asp Ile 
            900                 905                 910         


Leu Ser Pro Arg Leu Ile Arg Arg Gly Ser Lys Lys Arg Pro Ala Arg 
        915                 920                 925             


Ser Ser His Gln Glu Leu Arg Arg Asp Glu Gly Ser Gln Asp Gln Xaa 
    930                 935                 940                 


Gly Ser Leu Ser Arg Ala Arg Pro Ser Ser Arg His Val Arg His Ala 
945                 950                 955                 960 


Ser Val Pro Ala Xaa Phe Met Pro Ile Val Val Pro Glu Pro Pro Xaa 
                965                 970                 975     


Ser Val Gly Pro Pro Val Ala Val Pro Glu Pro Ile Gly Phe Pro Xaa 
            980                 985                 990         


Arg Ala His Pro Xaa Leu Gln Ala  Pro Ser Leu Glu Asp  Val Xaa Lys 
        995                 1000                 1005             


Gln Tyr  Met Leu Asn Leu His  Ser Gly Glu Val Pro  Ala Pro Val 
    1010                 1015                 1020             


Pro Val  Asp Met Pro Cys Leu  Pro Leu Ala Ala Pro  Pro Ser Ala 
    1025                 1030                 1035             


Glu Ala  Lys Pro Pro Glu Ala  Ala Arg Pro Ala Asp  Glu Pro Xaa 
    1040                 1045                 1050             


Pro Ala  Ser Lys Cys Cys Ser  Lys Pro Gln Val Asp  Met Arg Lys 
    1055                 1060                 1065             


His Val  Ala Met Xaa Leu Leu  Asp Xaa Glu Gln Ser  Tyr Val Glu 
    1070                 1075                 1080             


Ser Leu  Arg Xaa Leu Met Gln  Gly Tyr Met Gln Pro  Leu Lys Gln 
    1085                 1090                 1095             


Pro Glu  Asn Ser Val Leu Cys  Asp Pro Ser Leu Val  Asp Glu Ile 
    1100                 1105                 1110             


Phe Asp  Gln Ile Pro Glu Leu  Leu Glu His His Glu  Gln Phe Leu 
    1115                 1120                 1125             


Glu Gln  Val Arg His Cys Met  Gln Xaa Trp His Ala  Gln Gln Lys 
    1130                 1135                 1140             


Val Gly  Ala Leu Leu Val Gln  Ser Phe Ser Lys Asp  Val Leu Val 
    1145                 1150                 1155             


Asn Ile  Tyr Ser Ala Tyr Ile  Asp Asn Phe Leu Asn  Ala Lys Asp 
    1160                 1165                 1170             


Ala Val  Arg Val Ala Lys Glu  Ala Arg Pro Ala Phe  Leu Lys Phe 
    1175                 1180                 1185             


Leu Glu  Gln Ser Met Arg Glu  Asn Lys Glu Lys Gln  Ala Leu Ser 
    1190                 1195                 1200             


Asp Leu  Met Ile Lys Pro Val  Gln Arg Ile Pro Arg  Tyr Glu Leu 
    1205                 1210                 1215             


Leu Val  Lys Asp Leu Leu Lys  His Xaa Pro Glu Asp  His Pro Asp 
    1220                 1225                 1230             


His Pro  Leu Leu Leu Glu Ala  Gln Arg Asn Ile Lys  Gln Val Ala 
    1235                 1240                 1245             


Glu Arg  Ile Asn Lys Gly Val  Arg Ser Ala Glu Glu  Ala Glu Arg 
    1250                 1255                 1260             


His Ala  Arg Val Leu Gln Glu  Ile Glu Ala His Ile  Glu Gly Met 
    1265                 1270                 1275             


Glu Asp  Leu Gln Ala Pro Leu  Arg Arg Phe Leu Arg  Gln Glu Met 
    1280                 1285                 1290             


Val Ile  Glu Val Lys Ala Ile  Gly Gly Lys Lys Asp  Arg Ser Leu 
    1295                 1300                 1305             


Phe Leu  Phe Xaa Asp Leu Ile  Val Cys Xaa Xaa Leu  Lys Arg Lys 
    1310                 1315                 1320             


Ser Gly  Ser Leu Arg Arg Ser  Ser Met Ser Leu Tyr  Xaa Ala Ala 
    1325                 1330                 1335             


Ser Val  Ile Asp Xaa Ala Ser  Lys Tyr Lys Met Leu  Trp Lys Leu 
    1340                 1345                 1350             


Pro Leu  Glu Asp Ala Asp Ile  Ile Lys Gly Ala Ser  Gln Ala Xaa 
    1355                 1360                 1365             


Asn Arg  Glu Asn Ile Gln Lys  Ala Ile Ser Arg Leu  Asp Glu Asp 
    1370                 1375                 1380             


Leu Xaa  Xaa Leu Gly Gln Met  Ser Lys Leu Ser Glu  Ser Leu Gly 
    1385                 1390                 1395             


Phe Pro  His Gln Ser Leu Asp  Asp Ala Leu Arg Asp  Leu Ser Ala 
    1400                 1405                 1410             


Ala Met  His Arg Asp Leu Ser  Glu Lys Gln Ala Leu  Cys Tyr Ala 
    1415                 1420                 1425             


Leu Ser  Phe Pro Pro Xaa Lys  Leu Glu Leu Cys Ala  Xaa Arg Pro 
    1430                 1435                 1440             


Glu Gly  Xaa Asp Ser Tyr Ile  Phe Glu Phe Pro His  Pro Asp Ala 
    1445                 1450                 1455             


Arg Leu  Gly Phe Glu Gln Ala  Phe Asp Glu Ala Lys  Arg Lys Leu 
    1460                 1465                 1470             


Ala Ser  Ser Lys Ser Cys Leu  Asp Pro Glu Phe Leu  Lys Ala Ile 
    1475                 1480                 1485             


Pro Ile  Met Lys Xaa Arg Ser  Gly Met Gln Phe Ser  Cys Ala Ala 
    1490                 1495                 1500             


Pro Xaa  Leu Asn Ser Cys Pro  Glu Pro Ser Pro Glu  Val Trp Val 
    1505                 1510                 1515             


Cys Asn  Ser Asp Gly Tyr Val  Gly Gln Val Cys Leu  Leu Ser Leu 
    1520                 1525                 1530             


Arg Ala  Glu Pro Asp Val Glu  Ala Cys Ile Ala Val  Cys Ser Ala 
    1535                 1540                 1545             


Arg Ile  Leu Cys Ile Gly Ala  Val Pro Gly Leu Gln  Pro Arg Cys 
    1550                 1555                 1560             


His Arg  Glu Pro Pro Pro Ser  Leu Arg Ser Pro Pro  Glu Xaa Ala 
    1565                 1570                 1575             


Pro Glu  Pro Ala Gly Pro Glu  Leu Asp Val Glu Ala  Ala Ala Asp 
    1580                 1585                 1590             


Glu Glu  Ala Ala Xaa Leu Ala  Glu Pro Gly Pro Gln  Pro Cys Leu 
    1595                 1600                 1605             


His Ile  Ser Ile Ala Gly Ser  Gly Leu Glu Met Xaa  Pro Gly Leu 
    1610                 1615                 1620             


Gly Glu  Gly Asp Pro Arg Pro  Glu Leu Val Pro Phe  Asp Ser Asp 
    1625                 1630                 1635             


Ser Asp  Asp Glu Ser Ser Pro  Ser Pro Ser Gly Xaa  Leu Gln Ser 
    1640                 1645                 1650             


Gln Ala  Ser Arg Ser Xaa Ile  Ser Ser Ser Phe Gly  Asn Glu Glu 
    1655                 1660                 1665             


Xaa Pro  Ser Ser Lys Glu Ala  Xaa Ala Glu Xaa Xaa  Ser Ser Glu 
    1670                 1675                 1680             


Glu Glu  Gln Glu Pro Gly Phe  Leu Pro Leu Ser Gly  Ser Phe Gly 
    1685                 1690                 1695             


Pro Gly  Gly Pro Cys Gly Xaa  Ser Pro Met Asp Gly  Arg Ala Leu 
    1700                 1705                 1710             


Arg Arg  Ser Ser His Gly Ser  Phe Xaa Arg Gly Ser  Leu Glu Asp 
    1715                 1720                 1725             


Leu Leu  Ser Val Asp Pro Glu  Ala Tyr Gln Ser Ser  Val Trp Leu 
    1730                 1735                 1740             


Gly Xaa  Glu Asp Gly Cys Val  His Val Tyr Gln Ser  Ser Asp Ser 
    1745                 1750                 1755             


Ile Arg  Asp Arg Arg Asn Ser  Met Lys Leu Gln His  Ala Ala Ser 
    1760                 1765                 1770             


Val Xaa  Cys Ile Leu Tyr Leu  Asn Asn Gln Val Phe  Val Ser Leu 
    1775                 1780                 1785             


Ala Asn  Gly Glu Leu Val Val  Tyr Gln Arg Glu Ala  Gly His Phe 
    1790                 1795                 1800             


Trp Asp  Pro Gln Asn Phe Lys  Ser Val Xaa Leu Gly  Xaa Gln Gly 
    1805                 1810                 1815             


Ser Pro  Ile Xaa Lys Met Val  Ser Val Gly Gly Arg  Leu Trp Cys 
    1820                 1825                 1830             


Gly Cys  Gln Asn Arg Val Leu  Val Leu Ser Pro Asp  Xaa Leu Gln 
    1835                 1840                 1845             


Leu Glu  His Met Phe Tyr Val  Gly Gln Asp Ser Ser  Arg Cys Val 
    1850                 1855                 1860             


Ala Cys  Met Val Asp Ser Ser  Leu Gly Val Trp Val  Xaa Leu Lys 
    1865                 1870                 1875             


Gly Ser  Ala His Val Cys Leu  Tyr His Pro Asp Xaa  Phe Glu Gln 
    1880                 1885                 1890             


Leu Ala  Glu Val Asp Val Xaa  Pro Pro Val His Arg  Met Leu Ala 
    1895                 1900                 1905             


Gly Ser  Asp Ala Ile Ile Arg  Gln His Lys Ala Ala  Cys Leu Arg 
    1910                 1915                 1920             


Ile Xaa  Ala Leu Leu Val Cys  Glu Glu Leu Leu Trp  Val Gly Xaa 
    1925                 1930                 1935             


Ser Ala  Gly Val Val Leu Xaa  Met Pro Xaa Ser Pro  Gly Xaa Val 
    1940                 1945                 1950             


Ser Cys  Pro Arg Ala Pro Leu  Ser Pro Xaa Gly Leu  Gly Gln Gly 
    1955                 1960                 1965             


His Xaa  Gly His Val Arg Phe  Leu Ala Ala Val Gln  Leu Pro Asp 
    1970                 1975                 1980             


Gly Phe  Asn Leu Leu Cys Pro  Xaa Pro Pro Pro Pro  Pro Asp Xaa 
    1985                 1990                 1995             


Gly Pro  Glu Lys Leu Pro Ser  Leu Glu His Arg Asp  Ser Pro Trp 
    2000                 2005                 2010             


His Arg  Gly Pro Ala Pro Ala  Arg Pro Lys Met Leu  Val Ile Ser 
    2015                 2020                 2025             


Gly Gly  Asp Gly Tyr Glu Asp  Phe Arg Leu Ser Ser  Gly Gly Gly 
    2030                 2035                 2040             


Ser Ser  Ser Glu Xaa Val Gly  Arg Asp Asp Ser Xaa  Asn His Leu 
    2045                 2050                 2055             


Leu Leu  Trp Arg Val 
    2060             


<210> 2979
<211> 193
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<400> 2979
Xaa Ser Val Gly Pro Pro Val Ala Val Pro Glu Pro Ile Gly Phe Pro 
1               5                   10                  15      


Xaa Arg Ala His Pro Xaa Leu Gln Ala Pro Ser Leu Glu Asp Val Xaa 
            20                  25                  30          


Lys Gln Tyr Met Leu Asn Leu His Ser Gly Glu Val Pro Ala Pro Val 
        35                  40                  45              


Pro Val Asp Met Pro Cys Leu Pro Leu Ala Ala Pro Pro Ser Ala Glu 
    50                  55                  60                  


Ala Lys Pro Pro Glu Ala Ala Arg Pro Ala Asp Glu Pro Xaa Pro Ala 
65                  70                  75                  80  


Ser Lys Cys Cys Ser Lys Pro Gln Val Asp Met Arg Lys His Val Ala 
                85                  90                  95      


Met Xaa Leu Leu Asp Xaa Glu Gln Ser Tyr Val Glu Ser Leu Arg Xaa 
            100                 105                 110         


Leu Met Gln Val Gly Leu Gly Ala His Ser Pro Glu Asn Gly Leu Ser 
        115                 120                 125             


Glu Pro Arg Arg Leu Ser Asp Gly Cys Glu Gln Xaa Pro Phe Met Asp 
    130                 135                 140                 


Lys Gly Leu Arg Pro Glu Ser Arg Val Pro Gly Ile Arg Arg Leu Ser 
145                 150                 155                 160 


Met Lys Asn Pro Gln His Gly His Ser Arg Glu Gly Gly Arg Leu Leu 
                165                 170                 175     


Pro Gly Lys Arg Glu Cys Arg Gly Ala Arg Pro Pro Gln Gly Arg Arg 
            180                 185                 190         


Pro 
    


<210> 2980
<211> 87
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 2980
Met Xaa Val Ser Gln Lys Gly Gly Pro Gln Pro Xaa Pro Ser Pro Ala 
1               5                   10                  15      


Gly Pro Gly Xaa Gln Leu Gly Pro Ile Xaa Gly Glu Met Asp Glu Ala 
            20                  25                  30          


Asp Ser Ala Phe Leu Lys Phe Lys Gln Xaa Ala Asp Asp Ser Leu Ser 
        35                  40                  45              


Leu Xaa Ser Pro Asn Xaa Glu Ser Ile Phe Val Glu Asp Pro Tyr Xaa 
    50                  55                  60                  


Ala Ser Leu Arg Ser Glu Ile Glu Ser Asp Gly His Glu Phe Glu Ala 
65                  70                  75                  80  


Glu Ser Trp Ser Leu Ala Val 
                85          


<210> 2981
<211> 1015
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<400> 2981
Met Xaa Val Ser Gln Lys Gly Gly Pro Gln Pro Xaa Pro Ser Pro Ala 
1               5                   10                  15      


Gly Pro Gly Xaa Gln Leu Gly Pro Ile Xaa Gly Glu Met Asp Glu Ala 
            20                  25                  30          


Asp Ser Ala Phe Leu Lys Phe Lys Gln Xaa Ala Asp Asp Ser Leu Ser 
        35                  40                  45              


Leu Xaa Ser Pro Asn Xaa Glu Ser Ile Phe Val Glu Asp Pro Tyr Xaa 
    50                  55                  60                  


Ala Ser Leu Arg Ser Glu Ile Glu Ser Asp Gly His Glu Phe Glu Ala 
65                  70                  75                  80  


Glu Ser Trp Ser Leu Ala Val Asp Ala Ala Tyr Ala Lys Lys Gln Lys 
                85                  90                  95      


Arg Glu Val Val Lys Arg Gln Asp Val Leu Tyr Glu Leu Met Gln Xaa 
            100                 105                 110         


Glu Val His His Val Arg Xaa Leu Lys Ile Met Leu Lys Val Tyr Ser 
        115                 120                 125             


Arg Ala Leu Gln Glu Glu Leu Gln Phe Ser Ser Lys Ala Ile Gly Arg 
    130                 135                 140                 


Leu Phe Pro Cys Ala Asp Asp Leu Leu Glu Xaa His Ser His Phe Leu 
145                 150                 155                 160 


Ala Arg Leu Lys Glu Arg Arg Gln Glu Ser Leu Glu Glu Gly Ser Asp 
                165                 170                 175     


Arg Asn Tyr Val Ile Gln Lys Ile Gly Asp Leu Leu Val Gln Gln Phe 
            180                 185                 190         


Ser Gly Glu Asn Gly Glu Arg Met Lys Glu Lys Tyr Gly Val Phe Cys 
        195                 200                 205             


Ser Gly His Asn Glu Ala Val Ser His Tyr Lys Leu Leu Leu Gln Gln 
    210                 215                 220                 


Asn Lys Lys Phe Gln Asn Leu Ile Lys Lys Ile Gly Asn Phe Ser Ile 
225                 230                 235                 240 


Val Arg Arg Leu Gly Val Gln Glu Cys Ile Leu Leu Val Xaa Gln Arg 
                245                 250                 255     


Ile Xaa Lys Tyr Pro Val Leu Val Glu Arg Ile Ile Gln Asn Xaa Glu 
            260                 265                 270         


Ala Gly Xaa Glu Asp Tyr Glu Asp Leu Xaa Gln Ala Leu Asn Leu Ile 
        275                 280                 285             


Lys Asp Ile Ile Ser Gln Val Asp Ala Lys Val Ser Glu Cys Glu Lys 
    290                 295                 300                 


Gly Gln Arg Leu Arg Glu Ile Ala Gly Lys Met Asp Leu Lys Ser Ser 
305                 310                 315                 320 


Ser Lys Leu Lys Asn Gly Leu Xaa Phe Arg Lys Glu Asp Met Leu Gln 
                325                 330                 335     


Arg Gln Leu His Leu Glu Gly Met Leu Cys Trp Lys Xaa Xaa Ser Gly 
            340                 345                 350         


Arg Leu Lys Asp Ile Leu Ala Ile Leu Leu Xaa Asp Val Leu Leu Leu 
        355                 360                 365             


Leu Gln Glu Lys Asp Gln Lys Tyr Val Phe Ala Ser Val Asp Ser Lys 
    370                 375                 380                 


Pro Pro Val Ile Ser Leu Gln Lys Leu Ile Val Arg Glu Val Ala Asn 
385                 390                 395                 400 


Glu Glu Lys Ala Met Phe Leu Ile Ser Ala Ser Leu Gln Gly Pro Glu 
                405                 410                 415     


Met Tyr Glu Ile Tyr Xaa Ser Ser Lys Glu Asp Arg Asn Ala Trp Met 
            420                 425                 430         


Ala His Ile Gln Arg Ala Val Glu Ser Cys Pro Asp Glu Glu Glu Gly 
        435                 440                 445             


Pro Phe Ser Leu Pro Glu Glu Glu Arg Lys Val Val Glu Ala Arg Ala 
    450                 455                 460                 


Xaa Arg Leu Arg Asp Phe Gln Glu Arg Leu Ser Met Lys Asp Gln Leu 
465                 470                 475                 480 


Ile Ala Gln Ser Leu Leu Glu Lys Gln Gln Ile Tyr Leu Glu Met Ala 
                485                 490                 495     


Glu Met Gly Gly Leu Glu Asp Leu Pro Gln Pro Arg Gly Leu Phe Arg 
            500                 505                 510         


Gly Gly Asp Pro Ser Glu Xaa Leu Gln Gly Glu Leu Ile Leu Lys Ser 
        515                 520                 525             


Ala Met Ser Glu Ile Glu Gly Ile Gln Ser Leu Ile Cys Arg Gln Leu 
    530                 535                 540                 


Gly Ser Ala Asn Gly Gln Ala Glu Asp Gly Gly Ser Ser Xaa Gly Pro 
545                 550                 555                 560 


Pro Arg Arg Ala Glu Xaa Phe Ala Gly Tyr Asp Cys Xaa Asn Ser Pro 
                565                 570                 575     


Xaa Lys Asn Gly Ser Phe Lys Lys Lys Val Ser Ser Xaa Asp Pro Arg 
            580                 585                 590         


Pro Arg Asp Trp Arg Gly Pro Pro Asn Ser Pro Asp Leu Lys Leu Ser 
        595                 600                 605             


Asp Ser Asp Ile Pro Gly Ser Ser Glu Glu Ser Pro Gln Val Val Glu 
    610                 615                 620                 


Ala Pro Gly Xaa Glu Ser Asp Pro Arg Leu Pro Xaa Val Leu Glu Ser 
625                 630                 635                 640 


Glu Leu Val Gln Arg Ile Gln Xaa Leu Ser Gln Leu Leu Leu Asn Leu 
                645                 650                 655     


Gln Ala Val Ile Ala His Gln Asp Ser Tyr Val Glu Xaa Gln Arg Ala 
            660                 665                 670         


Ala Ile Gln Glu Arg Glu Lys Gln Phe Arg Leu Gln Ser Xaa Arg Gly 
        675                 680                 685             


Asn Leu Leu Leu Glu Gln Glu Arg Gln Arg Asn Phe Glu Lys Gln Arg 
    690                 695                 700                 


Glu Glu Arg Ala Ala Leu Glu Lys Leu Gln Ser Gln Leu Arg His Glu 
705                 710                 715                 720 


Gln Gln Arg Trp Glu Arg Glu Arg Gln Trp Gln His Gln Glu Leu Glu 
                725                 730                 735     


Arg Ala Gly Ala Arg Leu Gln Glu Arg Glu Gly Glu Ala Arg Gln Leu 
            740                 745                 750         


Arg Glu Arg Leu Glu Gln Glu Arg Ala Glu Leu Glu Arg Gln Arg Gln 
        755                 760                 765             


Ala Tyr Gln His Asp Leu Glu Arg Leu Arg Glu Ala Gln Arg Ala Val 
    770                 775                 780                 


Glu Arg Glu Arg Glu Arg Leu Glu Leu Leu Arg Arg Leu Lys Lys Gln 
785                 790                 795                 800 


Asn Xaa Ala Pro Gly Ala Leu Pro Pro Asp Xaa Leu Ala Glu Ala Gln 
                805                 810                 815     


Pro Pro Ser His Pro Pro Ser Phe Asn Gly Glu Gly Leu Glu Gly Pro 
            820                 825                 830         


Arg Val Ser Met Leu Pro Ser Gly Val Gly Pro Glu Tyr Ala Glu Arg 
        835                 840                 845             


Pro Glu Val Ala Arg Arg Asp Ser Ala Pro Xaa Glu Asn Arg Leu Ala 
    850                 855                 860                 


Lys Ser Asp Val Pro Ile Gln Leu Leu Ser Ala Xaa Asn Gln Phe Gln 
865                 870                 875                 880 


Arg Gln Ala Ala Val Gln Gln Gln Ile Pro Xaa Lys Leu Ala Ala Ser 
                885                 890                 895     


Xaa Lys Gly Gly Lys Asp Lys Gly Gly Lys Ser Arg Gly Ser Gln Arg 
            900                 905                 910         


Trp Glu Ser Ser Ala Ser Phe Asp Leu Lys Gln Gln Leu Leu Leu Asn 
        915                 920                 925             


Lys Leu Met Gly Lys Asp Glu Ser Xaa Ser Arg Asn Arg Arg Ser Leu 
    930                 935                 940                 


Ser Pro Ile Leu Pro Gly Arg His Ser Pro Ala Pro Pro Pro Asp Pro 
945                 950                 955                 960 


Gly Phe Pro Ala Pro Ser Pro Pro Pro Ala Asp Ser Pro Ser Glu Gly 
                965                 970                 975     


Phe Ser Leu Lys Ala Gly Gly Xaa Ala Leu Leu Pro Gly Pro Pro Ala 
            980                 985                 990         


Pro Ser Pro Leu Pro Ala Xaa Pro  Leu Ser Ala Lys Glu  Asp Ala Ser 
        995                 1000                 1005             


Lys Glu  Asp Val Ile Phe Phe  
    1010                 1015 


<210> 2982
<211> 1173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1017)..(1017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<400> 2982
Met Val Xaa Val Gly Xaa Asn Ile Leu Pro Ser Arg Pro Ala Ala Ser 
1               5                   10                  15      


Ala Asn Xaa Ala Arg Glu Asp Ala Ala Leu Phe Ser Arg Arg Ile Pro 
            20                  25                  30          


Pro Arg His Lys Asn Gly Ala Ala Gln Pro Gly Ala Ala Pro Gly Pro 
        35                  40                  45              


Gly Ala Pro Gly Ala Asn Met Gly Asn Ala His Ser Lys Ser Gly Asp 
    50                  55                  60                  


Arg His Ser Ala Leu Pro Gly Arg Pro Glu Leu Ser Phe Tyr Gly Ser 
65                  70                  75                  80  


Phe Pro Arg Lys Trp Ser Glu Asn Val Phe Leu Asp Asn Glu Leu Leu 
                85                  90                  95      


Xaa Ser Lys Ile Leu Ser Val Leu Arg Pro Gln Ser Glu Arg Gly Phe 
            100                 105                 110         


Arg Ala Gly Asp Leu Arg Tyr Pro Xaa His Phe Leu Ser Xaa Asn Ser 
        115                 120                 125             


Val Leu Ala Ser Val Xaa Ala Ser Leu Lys Glu His Pro Arg Gly Xaa 
    130                 135                 140                 


Leu Leu Ser Asp Gly Ser Pro Ala Leu Ser Arg Asn Val Gly Met Xaa 
145                 150                 155                 160 


Val Ser Gln Lys Gly Gly Pro Gln Pro Xaa Pro Ser Pro Ala Gly Pro 
                165                 170                 175     


Gly Xaa Gln Leu Gly Pro Ile Xaa Gly Glu Met Asp Glu Ala Asp Ser 
            180                 185                 190         


Ala Phe Leu Lys Phe Lys Gln Xaa Ala Asp Asp Ser Leu Ser Leu Xaa 
        195                 200                 205             


Ser Pro Asn Xaa Glu Ser Ile Phe Val Glu Asp Pro Tyr Xaa Ala Ser 
    210                 215                 220                 


Leu Arg Ser Glu Ile Glu Ser Asp Gly His Glu Phe Glu Ala Glu Ser 
225                 230                 235                 240 


Trp Ser Leu Ala Val Asp Ala Ala Tyr Ala Lys Lys Gln Lys Arg Glu 
                245                 250                 255     


Val Val Lys Arg Gln Asp Val Leu Tyr Glu Leu Met Gln Xaa Glu Val 
            260                 265                 270         


His His Val Arg Xaa Leu Lys Ile Met Leu Lys Val Tyr Ser Arg Ala 
        275                 280                 285             


Leu Gln Glu Glu Leu Gln Phe Ser Ser Lys Ala Ile Gly Arg Leu Phe 
    290                 295                 300                 


Pro Cys Ala Asp Asp Leu Leu Glu Xaa His Ser His Phe Leu Ala Arg 
305                 310                 315                 320 


Leu Lys Glu Arg Arg Gln Glu Ser Leu Glu Glu Gly Ser Asp Arg Asn 
                325                 330                 335     


Tyr Val Ile Gln Lys Ile Gly Asp Leu Leu Val Gln Gln Phe Ser Gly 
            340                 345                 350         


Glu Asn Gly Glu Arg Met Lys Glu Lys Tyr Gly Val Phe Cys Ser Gly 
        355                 360                 365             


His Asn Glu Ala Val Ser His Tyr Lys Leu Leu Leu Gln Gln Asn Lys 
    370                 375                 380                 


Lys Phe Gln Asn Leu Ile Lys Lys Ile Gly Asn Phe Ser Ile Val Arg 
385                 390                 395                 400 


Arg Leu Gly Val Gln Glu Cys Ile Leu Leu Val Xaa Gln Arg Ile Xaa 
                405                 410                 415     


Lys Tyr Pro Val Leu Val Glu Arg Ile Ile Gln Asn Xaa Glu Ala Gly 
            420                 425                 430         


Xaa Glu Asp Tyr Glu Asp Leu Xaa Gln Ala Leu Asn Leu Ile Lys Asp 
        435                 440                 445             


Ile Ile Ser Gln Val Asp Ala Lys Val Ser Glu Cys Glu Lys Gly Gln 
    450                 455                 460                 


Arg Leu Arg Glu Ile Ala Gly Lys Met Asp Leu Lys Ser Ser Ser Lys 
465                 470                 475                 480 


Leu Lys Asn Gly Leu Xaa Phe Arg Lys Glu Asp Met Leu Gln Arg Gln 
                485                 490                 495     


Leu His Leu Glu Gly Met Leu Cys Trp Lys Xaa Xaa Ser Gly Arg Leu 
            500                 505                 510         


Lys Asp Ile Leu Ala Ile Leu Leu Xaa Asp Val Leu Leu Leu Leu Gln 
        515                 520                 525             


Glu Lys Asp Gln Lys Tyr Val Phe Ala Ser Val Asp Ser Lys Pro Pro 
    530                 535                 540                 


Val Ile Ser Leu Gln Lys Leu Ile Val Arg Glu Val Ala Asn Glu Glu 
545                 550                 555                 560 


Lys Ala Met Phe Leu Ile Ser Ala Ser Leu Gln Gly Pro Glu Met Tyr 
                565                 570                 575     


Glu Ile Tyr Xaa Ser Ser Lys Glu Asp Arg Asn Ala Trp Met Ala His 
            580                 585                 590         


Ile Gln Arg Ala Val Glu Ser Cys Pro Asp Glu Glu Glu Gly Pro Phe 
        595                 600                 605             


Ser Leu Pro Glu Glu Glu Arg Lys Val Val Glu Ala Arg Ala Xaa Arg 
    610                 615                 620                 


Leu Arg Asp Phe Gln Glu Arg Leu Ser Met Lys Asp Gln Leu Ile Ala 
625                 630                 635                 640 


Gln Ser Leu Leu Glu Lys Gln Gln Ile Tyr Leu Glu Met Ala Glu Met 
                645                 650                 655     


Gly Gly Leu Glu Asp Leu Pro Gln Pro Arg Gly Leu Phe Arg Gly Gly 
            660                 665                 670         


Asp Pro Ser Glu Xaa Leu Gln Gly Glu Leu Ile Leu Lys Ser Ala Met 
        675                 680                 685             


Ser Glu Ile Glu Gly Ile Gln Ser Leu Ile Cys Arg Gln Leu Gly Ser 
    690                 695                 700                 


Ala Asn Gly Gln Ala Glu Asp Gly Gly Ser Ser Xaa Gly Pro Pro Arg 
705                 710                 715                 720 


Arg Ala Glu Xaa Phe Ala Gly Tyr Asp Cys Xaa Asn Ser Pro Xaa Lys 
                725                 730                 735     


Asn Gly Ser Phe Lys Lys Lys Val Ser Ser Xaa Asp Pro Arg Pro Arg 
            740                 745                 750         


Asp Trp Arg Gly Pro Pro Asn Ser Pro Asp Leu Lys Leu Ser Asp Ser 
        755                 760                 765             


Asp Ile Pro Gly Ser Ser Glu Glu Ser Pro Gln Val Val Glu Ala Pro 
    770                 775                 780                 


Gly Xaa Glu Ser Asp Pro Arg Leu Pro Xaa Val Leu Glu Ser Glu Leu 
785                 790                 795                 800 


Val Gln Arg Ile Gln Xaa Leu Ser Gln Leu Leu Leu Asn Leu Gln Ala 
                805                 810                 815     


Val Ile Ala His Gln Asp Ser Tyr Val Glu Xaa Gln Arg Ala Ala Ile 
            820                 825                 830         


Gln Glu Arg Glu Lys Gln Phe Arg Leu Gln Ser Xaa Arg Gly Asn Leu 
        835                 840                 845             


Leu Leu Glu Gln Glu Arg Gln Arg Asn Phe Glu Lys Gln Arg Glu Glu 
    850                 855                 860                 


Arg Ala Ala Leu Glu Lys Leu Gln Ser Gln Leu Arg His Glu Gln Gln 
865                 870                 875                 880 


Arg Trp Glu Arg Glu Arg Gln Trp Gln His Gln Glu Leu Glu Arg Ala 
                885                 890                 895     


Gly Ala Arg Leu Gln Glu Arg Glu Gly Glu Ala Arg Gln Leu Arg Glu 
            900                 905                 910         


Arg Leu Glu Gln Glu Arg Ala Glu Leu Glu Arg Gln Arg Gln Ala Tyr 
        915                 920                 925             


Gln His Asp Leu Glu Arg Leu Arg Glu Ala Gln Arg Ala Val Glu Arg 
    930                 935                 940                 


Glu Arg Glu Arg Leu Glu Leu Leu Arg Arg Leu Lys Lys Gln Asn Xaa 
945                 950                 955                 960 


Ala Pro Gly Ala Leu Pro Pro Asp Xaa Leu Ala Glu Ala Gln Pro Pro 
                965                 970                 975     


Ser His Pro Pro Ser Phe Asn Gly Glu Gly Leu Glu Gly Pro Arg Val 
            980                 985                 990         


Ser Met Leu Pro Ser Gly Val Gly  Pro Glu Tyr Ala Glu  Arg Pro Glu 
        995                 1000                 1005             


Val Ala  Arg Arg Asp Ser Ala  Pro Xaa Glu Asn Arg  Leu Ala Lys 
    1010                 1015                 1020             


Ser Asp  Val Pro Ile Gln Leu  Leu Ser Ala Xaa Asn  Gln Phe Gln 
    1025                 1030                 1035             


Arg Gln  Ala Ala Val Gln Gln  Gln Ile Pro Xaa Lys  Leu Ala Ala 
    1040                 1045                 1050             


Ser Xaa  Lys Gly Gly Lys Asp  Lys Gly Gly Lys Ser  Arg Gly Ser 
    1055                 1060                 1065             


Gln Arg  Trp Glu Ser Ser Ala  Ser Phe Asp Leu Lys  Gln Gln Leu 
    1070                 1075                 1080             


Leu Leu  Asn Lys Leu Met Gly  Lys Asp Glu Ser Xaa  Ser Arg Asn 
    1085                 1090                 1095             


Arg Arg  Ser Leu Ser Pro Ile  Leu Pro Gly Arg His  Ser Pro Ala 
    1100                 1105                 1110             


Pro Pro  Pro Asp Pro Gly Phe  Pro Ala Pro Ser Pro  Pro Pro Ala 
    1115                 1120                 1125             


Asp Ser  Pro Ser Glu Gly Phe  Ser Leu Lys Ala Gly  Gly Xaa Ala 
    1130                 1135                 1140             


Leu Leu  Pro Gly Pro Pro Ala  Pro Ser Pro Leu Pro  Ala Xaa Pro 
    1145                 1150                 1155             


Leu Ser  Ala Lys Glu Asp Ala  Ser Lys Glu Asp Val  Ile Phe Phe 
    1160                 1165                 1170             


<210> 2983
<211> 812
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<400> 2983
Xaa Arg Met Lys Glu Lys Tyr Gly Val Phe Cys Ser Gly His Asn Glu 
1               5                   10                  15      


Ala Val Ser His Tyr Lys Leu Leu Leu Gln Gln Asn Lys Lys Phe Gln 
            20                  25                  30          


Asn Leu Ile Lys Lys Ile Gly Asn Phe Ser Ile Val Arg Arg Leu Gly 
        35                  40                  45              


Val Gln Glu Cys Ile Leu Leu Val Xaa Gln Arg Ile Xaa Lys Tyr Pro 
    50                  55                  60                  


Val Leu Val Glu Arg Ile Ile Gln Asn Xaa Glu Ala Gly Xaa Glu Asp 
65                  70                  75                  80  


Tyr Glu Asp Leu Xaa Gln Ala Leu Asn Leu Ile Lys Asp Ile Ile Ser 
                85                  90                  95      


Gln Val Asp Ala Lys Val Ser Glu Cys Glu Lys Gly Gln Arg Leu Arg 
            100                 105                 110         


Glu Ile Ala Gly Lys Met Asp Leu Lys Ser Ser Ser Lys Leu Lys Asn 
        115                 120                 125             


Gly Leu Xaa Phe Arg Lys Glu Asp Met Leu Gln Arg Gln Leu His Leu 
    130                 135                 140                 


Glu Gly Met Leu Cys Trp Lys Xaa Xaa Ser Gly Arg Leu Lys Asp Ile 
145                 150                 155                 160 


Leu Ala Ile Leu Leu Xaa Asp Val Leu Leu Leu Leu Gln Glu Lys Asp 
                165                 170                 175     


Gln Lys Tyr Val Phe Ala Ser Val Asp Ser Lys Pro Pro Val Ile Ser 
            180                 185                 190         


Leu Gln Lys Leu Ile Val Arg Glu Val Ala Asn Glu Glu Lys Ala Met 
        195                 200                 205             


Phe Leu Ile Ser Ala Ser Leu Gln Gly Pro Glu Met Tyr Glu Ile Tyr 
    210                 215                 220                 


Xaa Ser Ser Lys Glu Asp Arg Asn Ala Trp Met Ala His Ile Gln Arg 
225                 230                 235                 240 


Ala Val Glu Ser Cys Pro Asp Glu Glu Glu Gly Pro Phe Ser Leu Pro 
                245                 250                 255     


Glu Glu Glu Arg Lys Val Val Glu Ala Arg Ala Xaa Arg Leu Arg Asp 
            260                 265                 270         


Phe Gln Glu Arg Leu Ser Met Lys Asp Gln Leu Ile Ala Gln Ser Leu 
        275                 280                 285             


Leu Glu Lys Gln Gln Ile Tyr Leu Glu Met Ala Glu Met Gly Gly Leu 
    290                 295                 300                 


Glu Asp Leu Pro Gln Pro Arg Gly Leu Phe Arg Gly Gly Asp Pro Ser 
305                 310                 315                 320 


Glu Xaa Leu Gln Gly Glu Leu Ile Leu Lys Ser Ala Met Ser Glu Ile 
                325                 330                 335     


Glu Gly Ile Gln Ser Leu Ile Cys Arg Gln Leu Gly Ser Ala Asn Gly 
            340                 345                 350         


Gln Ala Glu Asp Gly Gly Ser Ser Xaa Gly Pro Pro Arg Arg Ala Glu 
        355                 360                 365             


Xaa Phe Ala Gly Tyr Asp Cys Xaa Asn Ser Pro Xaa Lys Asn Gly Ser 
    370                 375                 380                 


Phe Lys Lys Lys Val Ser Ser Xaa Asp Pro Arg Pro Arg Asp Trp Arg 
385                 390                 395                 400 


Gly Pro Pro Asn Ser Pro Asp Leu Lys Leu Ser Asp Ser Asp Ile Pro 
                405                 410                 415     


Gly Ser Ser Glu Glu Ser Pro Gln Val Val Glu Ala Pro Gly Xaa Glu 
            420                 425                 430         


Ser Asp Pro Arg Leu Pro Xaa Val Leu Glu Ser Glu Leu Val Gln Arg 
        435                 440                 445             


Ile Gln Xaa Leu Ser Gln Leu Leu Leu Asn Leu Gln Asp Ser Tyr Val 
    450                 455                 460                 


Glu Xaa Gln Arg Ala Ala Ile Gln Glu Arg Glu Lys Gln Phe Arg Leu 
465                 470                 475                 480 


Gln Ser Xaa Arg Gly Asn Leu Leu Leu Glu Gln Glu Arg Gln Arg Asn 
                485                 490                 495     


Phe Glu Lys Gln Arg Glu Glu Arg Ala Ala Leu Glu Lys Leu Gln Ser 
            500                 505                 510         


Gln Leu Arg His Glu Gln Gln Arg Trp Glu Arg Glu Arg Gln Trp Gln 
        515                 520                 525             


His Gln Glu Leu Glu Arg Ala Gly Ala Arg Leu Gln Glu Arg Glu Gly 
    530                 535                 540                 


Glu Ala Arg Gln Leu Arg Glu Arg Leu Glu Gln Glu Arg Ala Glu Leu 
545                 550                 555                 560 


Glu Arg Gln Arg Gln Ala Tyr Gln His Asp Leu Glu Arg Leu Arg Glu 
                565                 570                 575     


Ala Gln Arg Ala Val Glu Arg Glu Arg Glu Arg Leu Glu Leu Leu Arg 
            580                 585                 590         


Arg Leu Lys Lys Gln Asn Xaa Ala Pro Gly Ala Leu Pro Pro Asp Xaa 
        595                 600                 605             


Leu Ala Glu Ala Gln Pro Pro Ser His Pro Pro Ser Phe Asn Gly Glu 
    610                 615                 620                 


Gly Leu Glu Gly Pro Arg Val Ser Met Leu Pro Ser Gly Val Gly Pro 
625                 630                 635                 640 


Glu Tyr Ala Glu Arg Pro Glu Val Ala Arg Arg Asp Ser Ala Pro Xaa 
                645                 650                 655     


Glu Asn Arg Leu Ala Lys Ser Asp Val Pro Ile Gln Leu Leu Ser Ala 
            660                 665                 670         


Xaa Asn Gln Phe Gln Arg Gln Ala Ala Val Gln Gln Gln Ile Pro Xaa 
        675                 680                 685             


Lys Leu Ala Ala Ser Xaa Lys Gly Gly Lys Asp Lys Gly Gly Lys Ser 
    690                 695                 700                 


Arg Gly Ser Gln Arg Trp Glu Ser Ser Ala Ser Phe Asp Leu Lys Gln 
705                 710                 715                 720 


Gln Leu Leu Leu Asn Lys Leu Met Gly Lys Asp Glu Ser Xaa Ser Arg 
                725                 730                 735     


Asn Arg Arg Ser Leu Ser Pro Ile Leu Pro Gly Arg His Ser Pro Ala 
            740                 745                 750         


Pro Pro Pro Asp Pro Gly Phe Pro Ala Pro Ser Pro Pro Pro Ala Asp 
        755                 760                 765             


Ser Pro Ser Glu Gly Phe Ser Leu Lys Ala Gly Gly Xaa Ala Leu Leu 
    770                 775                 780                 


Pro Gly Pro Pro Ala Pro Ser Pro Leu Pro Ala Xaa Pro Leu Ser Ala 
785                 790                 795                 800 


Lys Glu Asp Ala Ser Lys Glu Asp Val Ile Phe Phe 
                805                 810         


<210> 2984
<211> 167
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 2984
Glu Arg Leu Ala Gln Phe Pro Ala Ala Gly Arg Gly Ser Pro Gly Pro 
1               5                   10                  15      


Pro Gly Ala Arg Leu Gly Val Gly Leu Glu Lys Gly Arg Gly Arg Glu 
            20                  25                  30          


Val Trp Arg Pro Gly Val Trp Gly Cys Glu Ala Arg Ala Ser Glu Val 
        35                  40                  45              


Asn Trp Ser Cys Pro Phe Asp Pro Val Cys Ala Leu Pro Gln Ala Lys 
    50                  55                  60                  


Phe Glu Leu Ile Xaa Ser Glu Ala Ser Tyr Ile His Ser Leu Ser Val 
65                  70                  75                  80  


Ala Val Gly His Phe Leu Gly Ser Ala Glu Leu Ser Glu Cys Leu Gly 
                85                  90                  95      


Ala Gln Asp Lys Gln Trp Leu Phe Ser Lys Leu Pro Glu Val Lys Ser 
            100                 105                 110         


Xaa Ser Glu Arg Phe Leu Gln Asp Leu Glu Gln Arg Leu Glu Ala Asp 
        115                 120                 125             


Val Leu Arg Phe Ser Val Cys Asp Val Val Leu Asp His Cys Pro Ala 
    130                 135                 140                 


Phe Arg Arg Val Tyr Leu Pro Tyr Val Xaa Asn Gln Ala Tyr Gln Glu 
145                 150                 155                 160 


Arg Xaa Tyr Gln Arg Leu Leu 
                165         


<210> 2985
<211> 802
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<400> 2985
Met Asp Cys Gly Pro Pro Ala Xaa Leu Gln Pro His Leu Xaa Gly Pro 
1               5                   10                  15      


Pro Gly Xaa Ala His His Pro Val Ala Val Cys Gln Gln Glu Ser Leu 
            20                  25                  30          


Ser Phe Ala Glu Leu Pro Ala Leu Lys Pro Pro Ser Pro Val Cys Leu 
        35                  40                  45              


Asp Leu Phe Pro Val Ala Pro Glu Glu Leu Arg Ala Pro Gly Ser Arg 
    50                  55                  60                  


Trp Ser Leu Gly Xaa Pro Ala Pro Leu Gln Gly Leu Leu Trp Pro Leu 
65                  70                  75                  80  


Ser Pro Gly Gly Ser Asp Xaa Glu Ile Xaa Ser Gly Gly Met Arg Pro 
                85                  90                  95      


Ser Arg Ala Gly Ser Trp Pro His Cys Pro Gly Ala Gln Pro Pro Ala 
            100                 105                 110         


Leu Glu Gly Pro Trp Ser Pro Arg His Xaa Gln Pro Gln Arg Arg Ala 
        115                 120                 125             


Ser His Gly Ser Glu Lys Lys Ser Ala Trp Arg Lys Met Arg Val Tyr 
    130                 135                 140                 


Gln Arg Glu Glu Val Pro Gly Cys Pro Glu Ala His Ala Val Phe Leu 
145                 150                 155                 160 


Glu Pro Gly Gln Val Val Gln Glu Gln Ala Leu Ser Xaa Glu Glu Pro 
                165                 170                 175     


Arg Val Glu Leu Ser Gly Ser Xaa Arg Val Ser Leu Glu Gly Pro Glu 
            180                 185                 190         


Arg Arg Arg Phe Ser Ala Ser Glu Leu Met Xaa Arg Leu His Ser Ser 
        195                 200                 205             


Leu Arg Leu Gly Arg Asn Ser Ala Ala Arg Ala Leu Ile Ser Gly Ser 
    210                 215                 220                 


Gly Xaa Gly Ala Ala Arg Glu Gly Lys Ala Ser Gly Met Glu Ala Arg 
225                 230                 235                 240 


Ser Val Glu Met Ser Gly Asp Arg Val Ser Arg Pro Ala Pro Gly Asp 
                245                 250                 255     


Ser Arg Glu Gly Asp Trp Ser Glu Pro Arg Leu Asp Xaa Gln Glu Glu 
            260                 265                 270         


Pro Pro Leu Gly Ser Arg Ser Xaa Asn Glu Arg Arg Gln Ser Arg Phe 
        275                 280                 285             


Leu Leu Asn Ser Val Leu Tyr Gln Glu Tyr Ser Asp Val Ala Ser Ala 
    290                 295                 300                 


Arg Glu Leu Arg Arg Gln Gln Arg Glu Glu Glu Gly Pro Gly Asp Glu 
305                 310                 315                 320 


Ala Glu Gly Ala Glu Glu Gly Pro Gly Pro Pro Arg Ala Asn Leu Ser 
                325                 330                 335     


Pro Ser Ser Ser Phe Arg Ala Gln Arg Ser Ala Arg Gly Ser Xaa Phe 
            340                 345                 350         


Ser Leu Trp Gln Asp Ile Pro Asp Val Arg Gly Ser Gly Val Leu Ala 
        355                 360                 365             


Xaa Leu Ser Leu Arg Asp Cys Lys Leu Gln Glu Ala Lys Phe Glu Leu 
    370                 375                 380                 


Ile Xaa Ser Glu Ala Ser Tyr Ile His Ser Leu Ser Val Ala Val Gly 
385                 390                 395                 400 


His Phe Leu Gly Ser Ala Glu Leu Ser Glu Cys Leu Gly Ala Gln Asp 
                405                 410                 415     


Lys Gln Trp Leu Phe Ser Lys Leu Pro Glu Val Lys Ser Xaa Ser Glu 
            420                 425                 430         


Arg Phe Leu Gln Asp Leu Glu Gln Arg Leu Glu Ala Asp Val Leu Arg 
        435                 440                 445             


Phe Ser Val Cys Asp Val Val Leu Asp His Cys Pro Ala Phe Arg Arg 
    450                 455                 460                 


Val Tyr Leu Pro Tyr Val Xaa Asn Gln Ala Tyr Gln Glu Arg Xaa Tyr 
465                 470                 475                 480 


Gln Arg Leu Leu Leu Glu Asn Pro Arg Phe Pro Gly Ile Leu Ala Arg 
                485                 490                 495     


Leu Glu Glu Ser Pro Val Cys Gln Arg Leu Pro Leu Xaa Ser Phe Leu 
            500                 505                 510         


Ile Leu Pro Phe Gln Arg Ile Xaa Arg Leu Lys Met Leu Val Glu Asn 
        515                 520                 525             


Ile Leu Lys Arg Xaa Ala Gln Gly Ser Glu Asp Glu Asp Met Ala Xaa 
    530                 535                 540                 


Lys Ala Phe Asn Ala Leu Lys Glu Leu Val Gln Glu Cys Asn Ala Ser 
545                 550                 555                 560 


Val Gln Ser Met Lys Arg Xaa Glu Glu Leu Ile His Leu Ser Lys Lys 
                565                 570                 575     


Ile His Phe Glu Gly Lys Ile Phe Pro Leu Ile Ser Gln Ala Arg Trp 
            580                 585                 590         


Leu Val Arg His Gly Glu Leu Val Glu Leu Ala Pro Leu Pro Ala Ala 
        595                 600                 605             


Pro Pro Ala Lys Leu Lys Leu Ser Ser Lys Ala Val Tyr Leu His Leu 
    610                 615                 620                 


Phe Asn Asp Cys Leu Leu Leu Ser Arg Arg Lys Glu Leu Gly Lys Phe 
625                 630                 635                 640 


Ala Val Phe Val His Ala Lys Met Ala Glu Leu Gln Val Arg Asp Leu 
                645                 650                 655     


Ser Leu Lys Leu Gln Gly Ile Pro Gly His Val Phe Leu Leu Gln Leu 
            660                 665                 670         


Leu His Gly Gln His Met Lys His Gln Phe Leu Leu Arg Ala Arg Xaa 
        675                 680                 685             


Glu Ser Glu Lys Gln Arg Trp Ile Ser Ala Leu Cys Pro Ser Ser Pro 
    690                 695                 700                 


Gln Glu Asp Lys Glu Val Ile Ser Glu Gly Glu Asp Cys Pro Gln Val 
705                 710                 715                 720 


Gln Cys Val Arg Xaa Tyr Lys Ala Leu His Pro Asp Glu Leu Xaa Leu 
                725                 730                 735     


Glu Lys Xaa Asp Ile Leu Ser Val Arg Xaa Trp Xaa Ser Asp Gly Trp 
            740                 745                 750         


Leu Glu Gly Val Arg Leu Ala Asp Gly Glu Lys Gly Trp Val Pro Gln 
        755                 760                 765             


Ala Tyr Val Glu Glu Ile Ser Ser Leu Ser Ala Arg Leu Arg Asn Leu 
    770                 775                 780                 


Arg Glu Asn Lys Arg Val Xaa Ser Ala Xaa Ser Lys Leu Gly Glu Ala 
785                 790                 795                 800 


Pro Val 
        


<210> 2986
<211> 307
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<400> 2986
Xaa Arg Asp Arg Gly Gln Glu Arg Leu Ala Gln Phe Pro Ala Ala Gly 
1               5                   10                  15      


Arg Gly Ser Pro Gly Pro Pro Gly Ala Arg Leu Gly Val Gly Leu Glu 
            20                  25                  30          


Lys Gly Arg Gly Arg Glu Val Trp Arg Pro Gly Val Trp Gly Cys Glu 
        35                  40                  45              


Ala Arg Ala Ser Glu Val Asn Trp Ser Cys Pro Phe Asp Pro Val Cys 
    50                  55                  60                  


Ala Leu Pro Gln Ala Lys Phe Glu Leu Ile Xaa Ser Glu Ala Ser Tyr 
65                  70                  75                  80  


Ile His Ser Leu Ser Val Ala Val Gly His Phe Leu Gly Ser Ala Glu 
                85                  90                  95      


Leu Ser Glu Cys Leu Gly Ala Gln Asp Lys Gln Trp Leu Phe Ser Lys 
            100                 105                 110         


Leu Pro Glu Val Lys Ser Xaa Ser Glu Arg Phe Leu Gln Asp Leu Glu 
        115                 120                 125             


Gln Arg Leu Glu Ala Asp Val Leu Arg Phe Ser Val Cys Asp Val Val 
    130                 135                 140                 


Leu Asp His Cys Pro Ala Phe Arg Arg Val Tyr Leu Pro Tyr Val Xaa 
145                 150                 155                 160 


Asn Gln Ala Tyr Gln Glu Arg Xaa Tyr Gln Arg Leu Leu Leu Glu Asn 
                165                 170                 175     


Pro Arg Phe Pro Gly Ile Leu Ala Arg Leu Glu Glu Ser Pro Val Cys 
            180                 185                 190         


Gln Arg Leu Pro Leu Xaa Ser Phe Leu Ile Leu Pro Phe Gln Arg Ile 
        195                 200                 205             


Xaa Arg Leu Lys Met Leu Val Glu Asn Ile Leu Lys Arg Xaa Ala Gln 
    210                 215                 220                 


Gly Ser Glu Asp Glu Asp Met Ala Xaa Lys Ala Phe Asn Ala Leu Lys 
225                 230                 235                 240 


Glu Leu Val Gln Glu Cys Asn Ala Ser Val Gln Ser Met Lys Arg Xaa 
                245                 250                 255     


Glu Glu Leu Ile His Leu Ser Lys Lys Ile His Phe Glu Gly Lys Ile 
            260                 265                 270         


Phe Pro Leu Ile Ser Gln Ala Arg Trp Leu Val Arg His Gly Glu Leu 
        275                 280                 285             


Val Glu Leu Ala Pro Leu Pro Ala Ala Pro Pro Ala Lys Leu Lys Leu 
    290                 295                 300                 


Ser Ser Lys 
305         


<210> 2987
<211> 264
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<400> 2987
Met Ala Leu Pro Xaa Leu Pro Arg Gly Leu Phe Arg Ser Glu Ser Leu 
1               5                   10                  15      


Glu Ser Pro Arg Gly Glu Arg Leu Leu Gln Asp Ala Ile Arg Glu Val 
            20                  25                  30          


Glu Gly Leu Lys Asp Leu Leu Val Gly Pro Gly Val Glu Leu Leu Leu 
        35                  40                  45              


Xaa Pro Arg Glu Pro Ala Leu Pro Leu Glu Pro Asp Ser Gly Gly Asn 
    50                  55                  60                  


Xaa Ser Pro Gly Val Xaa Ala Asn Gly Glu Ala Arg Xaa Phe Asn Gly 
65                  70                  75                  80  


Ser Ile Glu Leu Cys Arg Ala Asp Ser Asp Ser Ser Gln Arg Asp Arg 
                85                  90                  95      


Asn Gly Asn Gln Leu Arg Ser Pro Gln Glu Glu Ala Leu Gln Arg Leu 
            100                 105                 110         


Val Asn Leu Tyr Gly Leu Leu His Gly Leu Gln Ala Ala Val Ala Gln 
        115                 120                 125             


Gln Asp Xaa Leu Met Glu Ala Arg Phe Pro Glu Gly Pro Glu Arg Arg 
    130                 135                 140                 


Glu Lys Leu Cys Arg Ala Asn Ser Arg Asp Gly Glu Ala Gly Arg Ala 
145                 150                 155                 160 


Gly Ala Ala Pro Val Ala Pro Glu Lys Gln Ala Xaa Glu Leu Ala Leu 
                165                 170                 175     


Leu Gln Arg Gln His Ala Leu Leu Gln Glu Glu Leu Arg Arg Cys Arg 
            180                 185                 190         


Arg Leu Gly Glu Glu Arg Ala Xaa Glu Ala Gly Ser Leu Glu Ala Arg 
        195                 200                 205             


Leu Arg Glu Ser Glu Gln Ala Arg Ala Leu Leu Glu Arg Glu Ala Glu 
    210                 215                 220                 


Glu Ala Arg Arg Gln Leu Ala Ala Leu Gly Gln Xaa Glu Pro Leu Pro 
225                 230                 235                 240 


Ala Glu Ala Pro Trp Ala Arg Arg Pro Val Asp Pro Arg Arg Arg Ser 
                245                 250                 255     


Ser Pro Gln Ala Met Pro Cys Xaa 
            260                 


<210> 2988
<211> 214
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<400> 2988
Met Lys Glu Ala Lys Asp Ala Arg Tyr Xaa Asn Gly His Leu Phe Xaa 
1               5                   10                  15      


Xaa Ile Ser Val Ser Gly Met Xaa Met Cys Tyr Ala Cys Asn Lys Ser 
            20                  25                  30          


Ile Xaa Ala Lys Glu Ala Leu Ile Cys Pro Xaa Cys Asn Val Xaa Ile 
        35                  40                  45              


His Asn Arg Cys Lys Asp Xaa Leu Ala Asn Cys Xaa Lys Val Lys Gln 
    50                  55                  60                  


Lys Gln Gln Lys Ala Ala Leu Leu Lys Asn Asn Xaa Ala Leu Gln Ser 
65                  70                  75                  80  


Val Ser Leu Arg Ser Lys Xaa Xaa Ile Arg Glu Arg Pro Ser Ser Ala 
                85                  90                  95      


Ile Tyr Pro Ser Asp Ser Phe Arg Gln Ser Leu Leu Gly Ser Arg Arg 
            100                 105                 110         


Gly Arg Ser Ser Leu Ser Leu Ala Lys Ser Val Ser Xaa Xaa Asn Ile 
        115                 120                 125             


Ala Gly His Phe Asn Asp Glu Ser Pro Leu Gly Leu Arg Arg Ile Leu 
    130                 135                 140                 


Ser Gln Ser Xaa Asp Ser Leu Asn Met Arg Asn Arg Xaa Leu Ser Val 
145                 150                 155                 160 


Glu Ser Leu Ile Asp Glu Ala Glu Val Ile Tyr Ser Glu Leu Met Ser 
                165                 170                 175     


Asp Phe Glu Met Asp Glu Lys Asp Phe Ala Ala Asp Ser Trp Ser Leu 
            180                 185                 190         


Ala Val Asp Ser Ser Phe Leu Gln Gln His Lys Lys Glu Val Met Lys 
        195                 200                 205             


Gln Gln Asp Val Ile Tyr 
    210                 


<210> 2989
<211> 229
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<400> 2989
Met Lys Glu Ala Lys Asp Ala Arg Tyr Xaa Asn Gly His Leu Phe Xaa 
1               5                   10                  15      


Xaa Ile Ser Val Ser Gly Met Xaa Met Cys Tyr Ala Cys Asn Lys Ser 
            20                  25                  30          


Ile Xaa Ala Lys Glu Ala Leu Ile Cys Pro Xaa Cys Asn Val Xaa Ile 
        35                  40                  45              


His Asn Arg Cys Lys Asp Xaa Leu Ala Asn Cys Xaa Lys Val Lys Gln 
    50                  55                  60                  


Lys Gln Gln Lys Ala Ala Leu Leu Lys Asn Asn Xaa Ala Leu Gln Ser 
65                  70                  75                  80  


Val Ser Leu Arg Ser Lys Xaa Xaa Ile Arg Glu Arg Pro Ser Ser Ala 
                85                  90                  95      


Ile Tyr Pro Ser Asp Ser Phe Arg Gln Ser Leu Leu Gly Ser Arg Arg 
            100                 105                 110         


Gly Arg Ser Ser Leu Ser Leu Ala Lys Ser Val Ser Xaa Xaa Asn Ile 
        115                 120                 125             


Ala Gly His Phe Asn Asp Glu Ser Pro Leu Gly Leu Arg Arg Ile Leu 
    130                 135                 140                 


Ser Gln Ser Xaa Asp Ser Leu Asn Met Arg Asn Arg Xaa Leu Ser Val 
145                 150                 155                 160 


Glu Ser Leu Ile Asp Glu Ala Glu Val Ile Tyr Ser Glu Leu Met Ser 
                165                 170                 175     


Asp Phe Glu Met Asp Glu Lys Asp Phe Ala Ala Asp Ser Trp Ser Leu 
            180                 185                 190         


Ala Val Asp Ser Ser Phe Leu Gln Gln His Lys Lys Glu Val Met Lys 
        195                 200                 205             


Gln Gln Asp Val Ile Tyr Glu Leu Ile Gln Xaa Glu Leu His His Val 
    210                 215                 220                 


Arg Xaa Leu Lys Ile 
225                 


<210> 2990
<211> 958
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<400> 2990
Met Lys Glu Ala Lys Asp Ala Arg Tyr Xaa Asn Gly His Leu Phe Xaa 
1               5                   10                  15      


Xaa Ile Ser Val Ser Gly Met Xaa Met Cys Tyr Ala Cys Asn Lys Ser 
            20                  25                  30          


Ile Xaa Ala Lys Glu Ala Leu Ile Cys Pro Xaa Cys Asn Val Xaa Ile 
        35                  40                  45              


His Asn Arg Cys Lys Asp Xaa Leu Ala Asn Cys Xaa Lys Val Lys Gln 
    50                  55                  60                  


Lys Gln Gln Lys Ala Ala Leu Leu Lys Asn Asn Xaa Ala Leu Gln Ser 
65                  70                  75                  80  


Val Ser Leu Arg Ser Lys Xaa Xaa Ile Arg Glu Arg Pro Ser Ser Ala 
                85                  90                  95      


Ile Tyr Pro Ser Asp Ser Phe Arg Gln Ser Leu Leu Gly Ser Arg Arg 
            100                 105                 110         


Gly Arg Ser Ser Leu Ser Leu Ala Lys Ser Val Ser Xaa Xaa Asn Ile 
        115                 120                 125             


Ala Gly His Phe Asn Asp Glu Ser Pro Leu Gly Leu Arg Arg Ile Leu 
    130                 135                 140                 


Ser Gln Ser Xaa Asp Ser Leu Asn Met Arg Asn Arg Xaa Leu Ser Val 
145                 150                 155                 160 


Glu Ser Leu Ile Asp Glu Glu Val Ile Tyr Ser Glu Leu Met Ser Asp 
                165                 170                 175     


Phe Glu Met Asp Glu Lys Asp Phe Ala Ala Asp Ser Trp Ser Leu Ala 
            180                 185                 190         


Val Asp Ser Ser Phe Leu Gln Gln His Lys Lys Glu Val Met Lys Gln 
        195                 200                 205             


Gln Asp Val Ile Tyr Glu Leu Ile Gln Xaa Glu Leu His His Val Arg 
    210                 215                 220                 


Xaa Leu Lys Ile Met Xaa Arg Leu Phe Arg Xaa Gly Met Leu Glu Glu 
225                 230                 235                 240 


Leu His Leu Glu Pro Gly Val Val Gln Gly Leu Phe Pro Cys Val Asp 
                245                 250                 255     


Glu Leu Ser Asp Ile His Xaa Arg Phe Leu Ser Gln Leu Leu Glu Arg 
            260                 265                 270         


Arg Arg Gln Ala Leu Cys Pro Gly Ser Xaa Arg Asn Phe Val Ile His 
        275                 280                 285             


Arg Leu Gly Asp Leu Leu Ile Ser Gln Phe Ser Gly Pro Ser Ala Glu 
    290                 295                 300                 


Gln Met Cys Lys Xaa Tyr Ser Glu Phe Cys Ser Arg His Ser Lys Ala 
305                 310                 315                 320 


Leu Lys Leu Tyr Lys Glu Leu Tyr Ala Arg Asp Lys Arg Phe Gln Gln 
                325                 330                 335     


Phe Ile Arg Lys Val Xaa Arg Pro Ala Val Leu Lys Arg His Gly Val 
            340                 345                 350         


Gln Glu Cys Ile Leu Leu Val Xaa Gln Arg Ile Xaa Lys Tyr Pro Leu 
        355                 360                 365             


Leu Ile Ser Arg Ile Leu Gln His Ser His Gly Ile Glu Glu Glu Arg 
    370                 375                 380                 


Gln Asp Leu Xaa Xaa Ala Leu Gly Leu Val Lys Glu Leu Leu Ser Asn 
385                 390                 395                 400 


Val Asp Glu Gly Ile Tyr Gln Leu Glu Lys Gly Ala Arg Leu Gln Glu 
                405                 410                 415     


Ile Tyr Asn Arg Met Asp Pro Arg Ala Gln Xaa Pro Val Pro Gly Lys 
            420                 425                 430         


Gly Pro Phe Gly Arg Glu Glu Leu Leu Arg Arg Lys Leu Ile His Asp 
        435                 440                 445             


Gly Cys Leu Leu Trp Lys Xaa Ala Xaa Gly Arg Phe Lys Asp Val Leu 
    450                 455                 460                 


Val Leu Leu Met Xaa Asp Val Leu Val Phe Leu Gln Glu Lys Asp Gln 
465                 470                 475                 480 


Lys Tyr Ile Phe Pro Xaa Leu Asp Lys Pro Ser Val Val Ser Leu Gln 
                485                 490                 495     


Asn Leu Ile Val Arg Asp Ile Ala Asn Gln Glu Lys Gly Met Phe Leu 
            500                 505                 510         


Ile Ser Ala Ala Pro Pro Glu Met Tyr Glu Val His Xaa Ala Ser Arg 
        515                 520                 525             


Asp Asp Arg Ser Xaa Trp Ile Arg Val Ile Gln Gln Ser Val Arg Xaa 
    530                 535                 540                 


Cys Pro Ser Arg Glu Asp Phe Pro Leu Ile Glu Xaa Glu Asp Glu Ala 
545                 550                 555                 560 


Tyr Leu Arg Arg Ile Lys Met Glu Leu Gln Gln Lys Asp Arg Ala Leu 
                565                 570                 575     


Val Glu Leu Leu Arg Glu Lys Val Gly Leu Phe Ala Glu Met Xaa His 
            580                 585                 590         


Phe Gln Ala Glu Glu Asp Gly Gly Ser Gly Met Ala Leu Pro Xaa Leu 
        595                 600                 605             


Pro Arg Gly Leu Phe Arg Ser Glu Ser Leu Glu Ser Pro Arg Gly Glu 
    610                 615                 620                 


Arg Leu Leu Gln Asp Ala Ile Arg Glu Val Glu Gly Leu Lys Asp Leu 
625                 630                 635                 640 


Leu Val Gly Pro Gly Val Glu Leu Leu Leu Xaa Pro Arg Glu Pro Ala 
                645                 650                 655     


Leu Pro Leu Glu Pro Asp Ser Gly Gly Asn Xaa Ser Pro Gly Val Xaa 
            660                 665                 670         


Ala Asn Gly Glu Ala Arg Xaa Phe Asn Gly Ser Ile Glu Leu Cys Arg 
        675                 680                 685             


Ala Asp Ser Asp Ser Ser Gln Arg Asp Arg Asn Gly Asn Gln Leu Arg 
    690                 695                 700                 


Ser Pro Gln Glu Glu Ala Leu Gln Arg Leu Val Asn Leu Tyr Gly Leu 
705                 710                 715                 720 


Leu His Gly Leu Gln Ala Ala Val Ala Gln Gln Asp Xaa Leu Met Glu 
                725                 730                 735     


Ala Arg Phe Pro Glu Gly Pro Glu Arg Arg Glu Lys Leu Cys Arg Ala 
            740                 745                 750         


Asn Ser Arg Asp Gly Glu Ala Gly Arg Ala Gly Ala Ala Pro Val Ala 
        755                 760                 765             


Pro Glu Lys Gln Ala Xaa Glu Leu Ala Leu Leu Gln Arg Gln His Ala 
    770                 775                 780                 


Leu Leu Gln Glu Glu Leu Arg Arg Cys Arg Arg Leu Gly Glu Glu Arg 
785                 790                 795                 800 


Ala Xaa Glu Ala Gly Ser Leu Glu Ala Arg Leu Arg Glu Ser Glu Gln 
                805                 810                 815     


Ala Arg Ala Leu Leu Glu Arg Glu Ala Glu Glu Ala Arg Arg Gln Leu 
            820                 825                 830         


Ala Ala Leu Gly Gln Xaa Glu Pro Leu Pro Ala Glu Ala Pro Trp Ala 
        835                 840                 845             


Arg Arg Pro Val Asp Pro Arg Arg Arg Ser Leu Pro Ala Gly Asp Ala 
    850                 855                 860                 


Leu Tyr Leu Ser Phe Asn Pro Pro Gln Pro Ser Arg Gly Xaa Asp Arg 
865                 870                 875                 880 


Leu Asp Leu Pro Val Xaa Xaa Arg Ser Val His Arg Asn Phe Glu Asp 
                885                 890                 895     


Arg Glu Arg Gln Glu Leu Gly Ser Pro Glu Glu Arg Leu Gln Asp Ser 
            900                 905                 910         


Ser Asp Pro Asp Xaa Gly Ser Glu Glu Glu Gly Ser Ser Arg Leu Ser 
        915                 920                 925             


Pro Pro His Ser Pro Arg Asp Phe Xaa Arg Met Gln Asp Ile Pro Glu 
    930                 935                 940                 


Glu Xaa Glu Ser Arg Asp Gly Glu Ala Val Ala Ser Glu Ser 
945                 950                 955             


<210> 2991
<211> 7
<212> PRT
<213> Homo sapiens

<400> 2991
Met Leu Ser Lys Ser Val Pro 
1               5           


<210> 2992
<211> 84
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<400> 2992
Met Leu Ser Lys Ser Val Pro Val Ser Gly Ile Asn Cys Leu Leu Asp 
1               5                   10                  15      


Arg Ser Asp Xaa Asp Gly Asn Val Ser Gln Ser Ser Ala Ile Asp Leu 
            20                  25                  30          


Arg Lys Arg Cys Ser Gln Leu Glu Gly His Ser Gly Xaa Arg Val Gly 
        35                  40                  45              


Ser Ser Leu Arg Gln Xaa Phe Ser Phe Leu Ser Gly Met Xaa Gly Lys 
    50                  55                  60                  


Ala Lys Xaa Arg Glu Lys Glu Lys Met Lys Glu Ala Lys Asp Ala Arg 
65                  70                  75                  80  


Tyr Xaa Asn Gly 
                


<210> 2993
<211> 1031
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<400> 2993
Met Leu Ser Lys Ser Val Pro Val Ser Gly Ile Asn Cys Leu Leu Asp 
1               5                   10                  15      


Arg Ser Asp Xaa Asp Gly Asn Val Ser Gln Ser Ser Ala Ile Asp Leu 
            20                  25                  30          


Arg Lys Arg Cys Ser Gln Leu Glu Gly His Ser Gly Xaa Arg Val Gly 
        35                  40                  45              


Ser Ser Leu Arg Gln Xaa Phe Ser Phe Leu Ser Gly Met Xaa Gly Lys 
    50                  55                  60                  


Ala Lys Xaa Arg Glu Lys Glu Lys Met Lys Glu Ala Lys Asp Ala Arg 
65                  70                  75                  80  


Tyr Xaa Asn Gly His Leu Phe Xaa Xaa Ile Ser Val Ser Gly Met Xaa 
                85                  90                  95      


Met Cys Tyr Ala Cys Asn Lys Ser Ile Xaa Ala Lys Glu Ala Leu Ile 
            100                 105                 110         


Cys Pro Xaa Cys Asn Val Xaa Ile His Asn Arg Cys Lys Asp Xaa Leu 
        115                 120                 125             


Ala Asn Cys Xaa Lys Val Lys Gln Lys Gln Gln Lys Ala Ala Leu Leu 
    130                 135                 140                 


Lys Asn Asn Xaa Ala Leu Gln Ser Val Ser Leu Arg Ser Lys Xaa Xaa 
145                 150                 155                 160 


Ile Arg Glu Arg Pro Ser Ser Ala Ile Tyr Pro Ser Asp Ser Phe Arg 
                165                 170                 175     


Gln Ser Leu Leu Gly Ser Arg Arg Gly Arg Ser Ser Leu Ser Leu Ala 
            180                 185                 190         


Lys Ser Val Ser Xaa Xaa Asn Ile Ala Gly His Phe Asn Asp Glu Ser 
        195                 200                 205             


Pro Leu Gly Leu Arg Arg Ile Leu Ser Gln Ser Xaa Asp Ser Leu Asn 
    210                 215                 220                 


Met Arg Asn Arg Xaa Leu Ser Val Glu Ser Leu Ile Asp Glu Ala Glu 
225                 230                 235                 240 


Val Ile Tyr Ser Glu Leu Met Ser Asp Phe Glu Met Asp Glu Lys Asp 
                245                 250                 255     


Phe Ala Ala Asp Ser Trp Ser Leu Ala Val Asp Ser Ser Phe Leu Gln 
            260                 265                 270         


Gln His Lys Lys Glu Val Met Lys Gln Gln Asp Val Ile Tyr Glu Leu 
        275                 280                 285             


Ile Gln Xaa Glu Leu His His Val Arg Xaa Leu Lys Ile Met Xaa Arg 
    290                 295                 300                 


Leu Phe Arg Xaa Gly Met Leu Glu Glu Leu His Leu Glu Pro Gly Val 
305                 310                 315                 320 


Val Gln Gly Leu Phe Pro Cys Val Asp Glu Leu Ser Asp Ile His Xaa 
                325                 330                 335     


Arg Phe Leu Ser Gln Leu Leu Glu Arg Arg Arg Gln Ala Leu Cys Pro 
            340                 345                 350         


Gly Ser Xaa Arg Asn Phe Val Ile His Arg Leu Gly Asp Leu Leu Ile 
        355                 360                 365             


Ser Gln Phe Ser Gly Pro Ser Ala Glu Gln Met Cys Lys Xaa Tyr Ser 
    370                 375                 380                 


Glu Phe Cys Ser Arg His Ser Lys Ala Leu Lys Leu Tyr Lys Glu Leu 
385                 390                 395                 400 


Tyr Ala Arg Asp Lys Arg Phe Gln Gln Phe Ile Arg Lys Val Xaa Arg 
                405                 410                 415     


Pro Ala Val Leu Lys Arg His Gly Val Gln Glu Cys Ile Leu Leu Val 
            420                 425                 430         


Xaa Gln Arg Ile Xaa Lys Tyr Pro Leu Leu Ile Ser Arg Ile Leu Gln 
        435                 440                 445             


His Ser His Gly Ile Glu Glu Glu Arg Gln Asp Leu Xaa Xaa Ala Leu 
    450                 455                 460                 


Gly Leu Val Lys Glu Leu Leu Ser Asn Val Asp Glu Gly Ile Tyr Gln 
465                 470                 475                 480 


Leu Glu Lys Gly Ala Arg Leu Gln Glu Ile Tyr Asn Arg Met Asp Pro 
                485                 490                 495     


Arg Ala Gln Xaa Pro Val Pro Gly Lys Gly Pro Phe Gly Arg Glu Glu 
            500                 505                 510         


Leu Leu Arg Arg Lys Leu Ile His Asp Gly Cys Leu Leu Trp Lys Xaa 
        515                 520                 525             


Ala Xaa Gly Arg Phe Lys Asp Val Leu Val Leu Leu Met Xaa Asp Val 
    530                 535                 540                 


Leu Val Phe Leu Gln Glu Lys Asp Gln Lys Tyr Ile Phe Pro Xaa Leu 
545                 550                 555                 560 


Asp Lys Pro Ser Val Val Ser Leu Gln Asn Leu Ile Val Arg Asp Ile 
                565                 570                 575     


Ala Asn Gln Glu Lys Gly Met Phe Leu Ile Ser Ala Ala Pro Pro Glu 
            580                 585                 590         


Met Tyr Glu Val His Xaa Ala Ser Arg Asp Asp Arg Ser Xaa Trp Ile 
        595                 600                 605             


Arg Val Ile Gln Gln Ser Val Arg Xaa Cys Pro Ser Arg Glu Asp Phe 
    610                 615                 620                 


Pro Leu Ile Glu Xaa Glu Asp Glu Ala Tyr Leu Arg Arg Ile Lys Met 
625                 630                 635                 640 


Glu Leu Gln Gln Lys Asp Arg Ala Leu Val Glu Leu Leu Arg Glu Lys 
                645                 650                 655     


Val Gly Leu Phe Ala Glu Met Xaa His Phe Gln Ala Glu Glu Asp Gly 
            660                 665                 670         


Gly Ser Gly Met Ala Leu Pro Xaa Leu Pro Arg Gly Leu Phe Arg Ser 
        675                 680                 685             


Glu Ser Leu Glu Ser Pro Arg Gly Glu Arg Leu Leu Gln Asp Ala Ile 
    690                 695                 700                 


Arg Glu Val Glu Gly Leu Lys Asp Leu Leu Val Gly Pro Gly Val Glu 
705                 710                 715                 720 


Leu Leu Leu Xaa Pro Arg Glu Pro Ala Leu Pro Leu Glu Pro Asp Ser 
                725                 730                 735     


Gly Gly Asn Xaa Ser Pro Gly Val Xaa Ala Asn Gly Glu Ala Arg Xaa 
            740                 745                 750         


Phe Asn Gly Ser Ile Glu Leu Cys Arg Ala Asp Ser Asp Ser Ser Gln 
        755                 760                 765             


Arg Asp Arg Asn Gly Asn Gln Leu Arg Ser Pro Gln Glu Glu Ala Leu 
    770                 775                 780                 


Gln Arg Leu Val Asn Leu Tyr Gly Leu Leu His Gly Leu Gln Ala Ala 
785                 790                 795                 800 


Val Ala Gln Gln Asp Xaa Leu Met Glu Ala Arg Phe Pro Glu Gly Pro 
                805                 810                 815     


Glu Arg Arg Glu Lys Leu Cys Arg Ala Asn Ser Arg Asp Gly Glu Ala 
            820                 825                 830         


Gly Arg Ala Gly Ala Ala Pro Val Ala Pro Glu Lys Gln Ala Xaa Glu 
        835                 840                 845             


Leu Ala Leu Leu Gln Arg Gln His Ala Leu Leu Gln Glu Glu Leu Arg 
    850                 855                 860                 


Arg Cys Arg Arg Leu Gly Glu Glu Arg Ala Xaa Glu Ala Gly Ser Leu 
865                 870                 875                 880 


Glu Ala Arg Leu Arg Glu Ser Glu Gln Ala Arg Ala Leu Leu Glu Arg 
                885                 890                 895     


Glu Ala Glu Glu Ala Arg Arg Gln Leu Ala Ala Leu Gly Gln Xaa Glu 
            900                 905                 910         


Pro Leu Pro Ala Glu Ala Pro Trp Ala Arg Arg Pro Val Asp Pro Arg 
        915                 920                 925             


Arg Arg Ser Leu Pro Ala Gly Asp Ala Leu Tyr Leu Ser Phe Asn Pro 
    930                 935                 940                 


Pro Gln Pro Ser Arg Gly Xaa Asp Arg Leu Asp Leu Pro Val Xaa Xaa 
945                 950                 955                 960 


Arg Ser Val His Arg Asn Phe Glu Asp Arg Glu Arg Gln Glu Leu Gly 
                965                 970                 975     


Ser Pro Glu Glu Arg Leu Gln Asp Ser Ser Asp Pro Asp Xaa Gly Ser 
            980                 985                 990         


Glu Glu Glu Gly Ser Ser Arg Leu  Ser Pro Pro His Ser  Pro Arg Asp 
        995                 1000                 1005             


Phe Xaa  Arg Met Gln Asp Ile  Pro Glu Glu Xaa Glu  Ser Arg Asp 
    1010                 1015                 1020             


Gly Glu  Ala Val Ala Ser Glu  Ser 
    1025                 1030     


<210> 2994
<211> 178
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<400> 2994
Met Ser Gly Asn Arg Arg Gln Pro Ser Arg Arg Gly Gln Xaa Arg Glu 
1               5                   10                  15      


Lys Glu Lys Met Lys Glu Ala Lys Asp Ala Arg Tyr Xaa Asn Gly His 
            20                  25                  30          


Leu Phe Xaa Xaa Ile Ser Val Ser Gly Met Xaa Met Cys Tyr Ala Cys 
        35                  40                  45              


Asn Lys Ser Ile Xaa Ala Lys Glu Ala Leu Ile Cys Pro Xaa Cys Asn 
    50                  55                  60                  


Val Xaa Ile His Asn Arg Cys Lys Asp Xaa Leu Ala Asn Cys Xaa Lys 
65                  70                  75                  80  


Val Lys Gln Lys Gln Gln Lys Ala Ala Leu Leu Lys Asn Asn Xaa Ala 
                85                  90                  95      


Leu Gln Ser Val Ser Leu Arg Ser Lys Xaa Xaa Ile Arg Glu Arg Pro 
            100                 105                 110         


Ser Ser Ala Ile Tyr Pro Ser Asp Ser Phe Arg Gln Ser Leu Leu Gly 
        115                 120                 125             


Ser Arg Arg Gly Arg Ser Ser Leu Ser Leu Ala Lys Ser Val Ser Xaa 
    130                 135                 140                 


Xaa Asn Ile Ala Gly His Phe Asn Asp Glu Ser Pro Leu Gly Leu Arg 
145                 150                 155                 160 


Arg Ile Leu Ser Gln Ser Xaa Asp Ser Leu Asn Met Arg Asn Arg Xaa 
                165                 170                 175     


Leu Ser 
        


<210> 2995
<211> 986
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<400> 2995
Met Ser Arg Ile Glu Ser Leu Xaa Arg Ala Arg Ile Asp Arg Ser Arg 
1               5                   10                  15      


Glu Leu Ala Ser Lys Xaa Arg Glu Lys Glu Lys Met Lys Glu Ala Lys 
            20                  25                  30          


Asp Ala Arg Tyr Xaa Asn Gly His Leu Phe Xaa Xaa Ile Ser Val Ser 
        35                  40                  45              


Gly Met Xaa Met Cys Tyr Ala Cys Asn Lys Ser Ile Xaa Ala Lys Glu 
    50                  55                  60                  


Ala Leu Ile Cys Pro Xaa Cys Asn Val Xaa Ile His Asn Arg Cys Lys 
65                  70                  75                  80  


Asp Xaa Leu Ala Asn Cys Xaa Lys Val Lys Gln Lys Gln Gln Lys Ala 
                85                  90                  95      


Ala Leu Leu Lys Asn Asn Xaa Ala Leu Gln Ser Val Ser Leu Arg Ser 
            100                 105                 110         


Lys Xaa Xaa Ile Arg Glu Arg Pro Ser Ser Ala Ile Tyr Pro Ser Asp 
        115                 120                 125             


Ser Phe Arg Gln Ser Leu Leu Gly Ser Arg Arg Gly Arg Ser Ser Leu 
    130                 135                 140                 


Ser Leu Ala Lys Ser Val Ser Xaa Xaa Asn Ile Ala Gly His Phe Asn 
145                 150                 155                 160 


Asp Glu Ser Pro Leu Gly Leu Arg Arg Ile Leu Ser Gln Ser Xaa Asp 
                165                 170                 175     


Ser Leu Asn Met Arg Asn Arg Xaa Leu Ser Val Glu Ser Leu Ile Asp 
            180                 185                 190         


Glu Ala Glu Val Ile Tyr Ser Glu Leu Met Ser Asp Phe Glu Met Asp 
        195                 200                 205             


Glu Lys Asp Phe Ala Ala Asp Ser Trp Ser Leu Ala Val Asp Ser Ser 
    210                 215                 220                 


Phe Leu Gln Gln His Lys Lys Glu Val Met Lys Gln Gln Asp Val Ile 
225                 230                 235                 240 


Tyr Glu Leu Ile Gln Xaa Glu Leu His His Val Arg Xaa Leu Lys Ile 
                245                 250                 255     


Met Xaa Arg Leu Phe Arg Xaa Gly Met Leu Glu Glu Leu His Leu Glu 
            260                 265                 270         


Pro Gly Val Val Gln Gly Leu Phe Pro Cys Val Asp Glu Leu Ser Asp 
        275                 280                 285             


Ile His Xaa Arg Phe Leu Ser Gln Leu Leu Glu Arg Arg Arg Gln Ala 
    290                 295                 300                 


Leu Cys Pro Gly Ser Xaa Arg Asn Phe Val Ile His Arg Leu Gly Asp 
305                 310                 315                 320 


Leu Leu Ile Ser Gln Phe Ser Gly Pro Ser Ala Glu Gln Met Cys Lys 
                325                 330                 335     


Xaa Tyr Ser Glu Phe Cys Ser Arg His Ser Lys Ala Leu Lys Leu Tyr 
            340                 345                 350         


Lys Glu Leu Tyr Ala Arg Asp Lys Arg Phe Gln Gln Phe Ile Arg Lys 
        355                 360                 365             


Val Xaa Arg Pro Ala Val Leu Lys Arg His Gly Val Gln Glu Cys Ile 
    370                 375                 380                 


Leu Leu Val Xaa Gln Arg Ile Xaa Lys Tyr Pro Leu Leu Ile Ser Arg 
385                 390                 395                 400 


Ile Leu Gln His Ser His Gly Ile Glu Glu Glu Arg Gln Asp Leu Xaa 
                405                 410                 415     


Xaa Ala Leu Gly Leu Val Lys Glu Leu Leu Ser Asn Val Asp Glu Gly 
            420                 425                 430         


Ile Tyr Gln Leu Glu Lys Gly Ala Arg Leu Gln Glu Ile Tyr Asn Arg 
        435                 440                 445             


Met Asp Pro Arg Ala Gln Xaa Pro Val Pro Gly Lys Gly Pro Phe Gly 
    450                 455                 460                 


Arg Glu Glu Leu Leu Arg Arg Lys Leu Ile His Asp Gly Cys Leu Leu 
465                 470                 475                 480 


Trp Lys Xaa Ala Xaa Gly Arg Phe Lys Asp Val Leu Val Leu Leu Met 
                485                 490                 495     


Xaa Asp Val Leu Val Phe Leu Gln Glu Lys Asp Gln Lys Tyr Ile Phe 
            500                 505                 510         


Pro Xaa Leu Asp Lys Pro Ser Val Val Ser Leu Gln Asn Leu Ile Val 
        515                 520                 525             


Arg Asp Ile Ala Asn Gln Glu Lys Gly Met Phe Leu Ile Ser Ala Ala 
    530                 535                 540                 


Pro Pro Glu Met Tyr Glu Val His Xaa Ala Ser Arg Asp Asp Arg Ser 
545                 550                 555                 560 


Xaa Trp Ile Arg Val Ile Gln Gln Ser Val Arg Xaa Cys Pro Ser Arg 
                565                 570                 575     


Glu Asp Phe Pro Leu Ile Glu Xaa Glu Asp Glu Ala Tyr Leu Arg Arg 
            580                 585                 590         


Ile Lys Met Glu Leu Gln Gln Lys Asp Arg Ala Leu Val Glu Leu Leu 
        595                 600                 605             


Arg Glu Lys Val Gly Leu Phe Ala Glu Met Xaa His Phe Gln Ala Glu 
    610                 615                 620                 


Glu Asp Gly Gly Ser Gly Met Ala Leu Pro Xaa Leu Pro Arg Gly Leu 
625                 630                 635                 640 


Phe Arg Ser Glu Ser Leu Glu Ser Pro Arg Gly Glu Arg Leu Leu Gln 
                645                 650                 655     


Asp Ala Ile Arg Glu Val Glu Gly Leu Lys Asp Leu Leu Val Gly Pro 
            660                 665                 670         


Gly Val Glu Leu Leu Leu Xaa Pro Arg Glu Pro Ala Leu Pro Leu Glu 
        675                 680                 685             


Pro Asp Ser Gly Gly Asn Xaa Ser Pro Gly Val Xaa Ala Asn Gly Glu 
    690                 695                 700                 


Ala Arg Xaa Phe Asn Gly Ser Ile Glu Leu Cys Arg Ala Asp Ser Asp 
705                 710                 715                 720 


Ser Ser Gln Arg Asp Arg Asn Gly Asn Gln Leu Arg Ser Pro Gln Glu 
                725                 730                 735     


Glu Ala Leu Gln Arg Leu Val Asn Leu Tyr Gly Leu Leu His Gly Leu 
            740                 745                 750         


Gln Ala Ala Val Ala Gln Gln Asp Xaa Leu Met Glu Ala Arg Phe Pro 
        755                 760                 765             


Glu Gly Pro Glu Arg Arg Glu Lys Leu Cys Arg Ala Asn Ser Arg Asp 
    770                 775                 780                 


Gly Glu Ala Gly Arg Ala Gly Ala Ala Pro Val Ala Pro Glu Lys Gln 
785                 790                 795                 800 


Ala Xaa Glu Leu Ala Leu Leu Gln Arg Gln His Ala Leu Leu Gln Glu 
                805                 810                 815     


Glu Leu Arg Arg Cys Arg Arg Leu Gly Glu Glu Arg Ala Xaa Glu Ala 
            820                 825                 830         


Gly Ser Leu Glu Ala Arg Leu Arg Glu Ser Glu Gln Ala Arg Ala Leu 
        835                 840                 845             


Leu Glu Arg Glu Ala Glu Glu Ala Arg Arg Gln Leu Ala Ala Leu Gly 
    850                 855                 860                 


Gln Xaa Glu Pro Leu Pro Ala Glu Ala Pro Trp Ala Arg Arg Pro Val 
865                 870                 875                 880 


Asp Pro Arg Arg Arg Ser Leu Pro Ala Gly Asp Ala Leu Tyr Leu Ser 
                885                 890                 895     


Phe Asn Pro Pro Gln Pro Ser Arg Gly Xaa Asp Arg Leu Asp Leu Pro 
            900                 905                 910         


Val Xaa Xaa Arg Ser Val His Arg Asn Phe Glu Asp Arg Glu Arg Gln 
        915                 920                 925             


Glu Leu Gly Ser Pro Glu Glu Arg Leu Gln Asp Ser Ser Asp Pro Asp 
    930                 935                 940                 


Xaa Gly Ser Glu Glu Glu Gly Ser Ser Arg Leu Ser Pro Pro His Ser 
945                 950                 955                 960 


Pro Arg Asp Phe Xaa Arg Met Gln Asp Ile Pro Glu Glu Xaa Glu Ser 
                965                 970                 975     


Arg Asp Gly Glu Ala Val Ala Ser Glu Ser 
            980                 985     


<210> 2996
<211> 985
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<400> 2996
Met Ser Arg Ile Glu Ser Leu Xaa Arg Ala Arg Ile Asp Arg Ser Arg 
1               5                   10                  15      


Glu Leu Ala Ser Lys Xaa Arg Glu Lys Glu Lys Met Lys Glu Ala Lys 
            20                  25                  30          


Asp Ala Arg Tyr Xaa Asn Gly His Leu Phe Xaa Xaa Ile Ser Val Ser 
        35                  40                  45              


Gly Met Xaa Met Cys Tyr Ala Cys Asn Lys Ser Ile Xaa Ala Lys Glu 
    50                  55                  60                  


Ala Leu Ile Cys Pro Xaa Cys Asn Val Xaa Ile His Asn Arg Cys Lys 
65                  70                  75                  80  


Asp Xaa Leu Ala Asn Cys Xaa Lys Val Lys Gln Lys Gln Gln Lys Ala 
                85                  90                  95      


Ala Leu Leu Lys Asn Asn Xaa Ala Leu Gln Ser Val Ser Leu Arg Ser 
            100                 105                 110         


Lys Xaa Xaa Ile Arg Glu Arg Pro Ser Ser Ala Ile Tyr Pro Ser Asp 
        115                 120                 125             


Ser Phe Arg Gln Ser Leu Leu Gly Ser Arg Arg Gly Arg Ser Ser Leu 
    130                 135                 140                 


Ser Leu Ala Lys Ser Val Ser Xaa Xaa Asn Ile Ala Gly His Phe Asn 
145                 150                 155                 160 


Asp Glu Ser Pro Leu Gly Leu Arg Arg Ile Leu Ser Gln Ser Xaa Asp 
                165                 170                 175     


Ser Leu Asn Met Arg Asn Arg Xaa Leu Ser Val Glu Ser Leu Ile Asp 
            180                 185                 190         


Glu Glu Val Ile Tyr Ser Glu Leu Met Ser Asp Phe Glu Met Asp Glu 
        195                 200                 205             


Lys Asp Phe Ala Ala Asp Ser Trp Ser Leu Ala Val Asp Ser Ser Phe 
    210                 215                 220                 


Leu Gln Gln His Lys Lys Glu Val Met Lys Gln Gln Asp Val Ile Tyr 
225                 230                 235                 240 


Glu Leu Ile Gln Xaa Glu Leu His His Val Arg Xaa Leu Lys Ile Met 
                245                 250                 255     


Xaa Arg Leu Phe Arg Xaa Gly Met Leu Glu Glu Leu His Leu Glu Pro 
            260                 265                 270         


Gly Val Val Gln Gly Leu Phe Pro Cys Val Asp Glu Leu Ser Asp Ile 
        275                 280                 285             


His Xaa Arg Phe Leu Ser Gln Leu Leu Glu Arg Arg Arg Gln Ala Leu 
    290                 295                 300                 


Cys Pro Gly Ser Xaa Arg Asn Phe Val Ile His Arg Leu Gly Asp Leu 
305                 310                 315                 320 


Leu Ile Ser Gln Phe Ser Gly Pro Ser Ala Glu Gln Met Cys Lys Xaa 
                325                 330                 335     


Tyr Ser Glu Phe Cys Ser Arg His Ser Lys Ala Leu Lys Leu Tyr Lys 
            340                 345                 350         


Glu Leu Tyr Ala Arg Asp Lys Arg Phe Gln Gln Phe Ile Arg Lys Val 
        355                 360                 365             


Xaa Arg Pro Ala Val Leu Lys Arg His Gly Val Gln Glu Cys Ile Leu 
    370                 375                 380                 


Leu Val Xaa Gln Arg Ile Xaa Lys Tyr Pro Leu Leu Ile Ser Arg Ile 
385                 390                 395                 400 


Leu Gln His Ser His Gly Ile Glu Glu Glu Arg Gln Asp Leu Xaa Xaa 
                405                 410                 415     


Ala Leu Gly Leu Val Lys Glu Leu Leu Ser Asn Val Asp Glu Gly Ile 
            420                 425                 430         


Tyr Gln Leu Glu Lys Gly Ala Arg Leu Gln Glu Ile Tyr Asn Arg Met 
        435                 440                 445             


Asp Pro Arg Ala Gln Xaa Pro Val Pro Gly Lys Gly Pro Phe Gly Arg 
    450                 455                 460                 


Glu Glu Leu Leu Arg Arg Lys Leu Ile His Asp Gly Cys Leu Leu Trp 
465                 470                 475                 480 


Lys Xaa Ala Xaa Gly Arg Phe Lys Asp Val Leu Val Leu Leu Met Xaa 
                485                 490                 495     


Asp Val Leu Val Phe Leu Gln Glu Lys Asp Gln Lys Tyr Ile Phe Pro 
            500                 505                 510         


Xaa Leu Asp Lys Pro Ser Val Val Ser Leu Gln Asn Leu Ile Val Arg 
        515                 520                 525             


Asp Ile Ala Asn Gln Glu Lys Gly Met Phe Leu Ile Ser Ala Ala Pro 
    530                 535                 540                 


Pro Glu Met Tyr Glu Val His Xaa Ala Ser Arg Asp Asp Arg Ser Xaa 
545                 550                 555                 560 


Trp Ile Arg Val Ile Gln Gln Ser Val Arg Xaa Cys Pro Ser Arg Glu 
                565                 570                 575     


Asp Phe Pro Leu Ile Glu Xaa Glu Asp Glu Ala Tyr Leu Arg Arg Ile 
            580                 585                 590         


Lys Met Glu Leu Gln Gln Lys Asp Arg Ala Leu Val Glu Leu Leu Arg 
        595                 600                 605             


Glu Lys Val Gly Leu Phe Ala Glu Met Xaa His Phe Gln Ala Glu Glu 
    610                 615                 620                 


Asp Gly Gly Ser Gly Met Ala Leu Pro Xaa Leu Pro Arg Gly Leu Phe 
625                 630                 635                 640 


Arg Ser Glu Ser Leu Glu Ser Pro Arg Gly Glu Arg Leu Leu Gln Asp 
                645                 650                 655     


Ala Ile Arg Glu Val Glu Gly Leu Lys Asp Leu Leu Val Gly Pro Gly 
            660                 665                 670         


Val Glu Leu Leu Leu Xaa Pro Arg Glu Pro Ala Leu Pro Leu Glu Pro 
        675                 680                 685             


Asp Ser Gly Gly Asn Xaa Ser Pro Gly Val Xaa Ala Asn Gly Glu Ala 
    690                 695                 700                 


Arg Xaa Phe Asn Gly Ser Ile Glu Leu Cys Arg Ala Asp Ser Asp Ser 
705                 710                 715                 720 


Ser Gln Arg Asp Arg Asn Gly Asn Gln Leu Arg Ser Pro Gln Glu Glu 
                725                 730                 735     


Ala Leu Gln Arg Leu Val Asn Leu Tyr Gly Leu Leu His Gly Leu Gln 
            740                 745                 750         


Ala Ala Val Ala Gln Gln Asp Xaa Leu Met Glu Ala Arg Phe Pro Glu 
        755                 760                 765             


Gly Pro Glu Arg Arg Glu Lys Leu Cys Arg Ala Asn Ser Arg Asp Gly 
    770                 775                 780                 


Glu Ala Gly Arg Ala Gly Ala Ala Pro Val Ala Pro Glu Lys Gln Ala 
785                 790                 795                 800 


Xaa Glu Leu Ala Leu Leu Gln Arg Gln His Ala Leu Leu Gln Glu Glu 
                805                 810                 815     


Leu Arg Arg Cys Arg Arg Leu Gly Glu Glu Arg Ala Xaa Glu Ala Gly 
            820                 825                 830         


Ser Leu Glu Ala Arg Leu Arg Glu Ser Glu Gln Ala Arg Ala Leu Leu 
        835                 840                 845             


Glu Arg Glu Ala Glu Glu Ala Arg Arg Gln Leu Ala Ala Leu Gly Gln 
    850                 855                 860                 


Xaa Glu Pro Leu Pro Ala Glu Ala Pro Trp Ala Arg Arg Pro Val Asp 
865                 870                 875                 880 


Pro Arg Arg Arg Ser Leu Pro Ala Gly Asp Ala Leu Tyr Leu Ser Phe 
                885                 890                 895     


Asn Pro Pro Gln Pro Ser Arg Gly Xaa Asp Arg Leu Asp Leu Pro Val 
            900                 905                 910         


Xaa Xaa Arg Ser Val His Arg Asn Phe Glu Asp Arg Glu Arg Gln Glu 
        915                 920                 925             


Leu Gly Ser Pro Glu Glu Arg Leu Gln Asp Ser Ser Asp Pro Asp Xaa 
    930                 935                 940                 


Gly Ser Glu Glu Glu Gly Ser Ser Arg Leu Ser Pro Pro His Ser Pro 
945                 950                 955                 960 


Arg Asp Phe Xaa Arg Met Gln Asp Ile Pro Glu Glu Xaa Glu Ser Arg 
                965                 970                 975     


Asp Gly Glu Ala Val Ala Ser Glu Ser 
            980                 985 


<210> 2997
<211> 59
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<400> 2997
Gln Gln Lys Ala Ala Leu Leu Lys Asn Asn Xaa Ala Leu Gln Ser Val 
1               5                   10                  15      


Ser Leu Arg Ser Lys Asn Ile Ser Met Met Ser Leu Pro Trp Gly Cys 
            20                  25                  30          


Ala Gly Ser Ser His Ser Pro Gln Xaa Pro Ser Xaa Cys Gly Xaa Glu 
        35                  40                  45              


Pro Tyr Pro Trp Asn Pro Ser Leu Xaa Lys Arg 
    50                  55                  


<210> 2998
<211> 263
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<400> 2998
Xaa Gln Glu Glu Ala Leu Gln Arg Leu Val Asn Leu Tyr Gly Leu Leu 
1               5                   10                  15      


His Gly Leu Gln Ala Ala Val Ala Gln Gln Asp Xaa Leu Met Glu Ala 
            20                  25                  30          


Arg Phe Pro Glu Gly Pro Glu Arg Arg Glu Lys Leu Cys Arg Ala Asn 
        35                  40                  45              


Ser Arg Asp Gly Glu Ala Gly Arg Ala Gly Ala Ala Pro Val Ala Pro 
    50                  55                  60                  


Glu Lys Gln Ala Xaa Glu Leu Ala Leu Leu Gln Arg Gln His Ala Leu 
65                  70                  75                  80  


Leu Gln Glu Glu Leu Arg Arg Cys Arg Arg Leu Gly Glu Glu Arg Ala 
                85                  90                  95      


Xaa Glu Ala Gly Ser Leu Glu Ala Arg Leu Arg Glu Ser Glu Gln Ala 
            100                 105                 110         


Arg Ala Leu Leu Glu Arg Glu Ala Glu Glu Ala Arg Arg Gln Leu Ala 
        115                 120                 125             


Ala Leu Gly Gln Xaa Glu Pro Leu Pro Ala Glu Ala Pro Trp Ala Arg 
    130                 135                 140                 


Arg Pro Val Asp Pro Arg Arg Arg Ser Leu Pro Ala Gly Asp Ala Leu 
145                 150                 155                 160 


Tyr Leu Ser Phe Asn Pro Pro Gln Pro Ser Arg Gly Xaa Asp Arg Leu 
                165                 170                 175     


Asp Leu Pro Val Xaa Xaa Arg Ser Val His Arg Asn Phe Glu Asp Arg 
            180                 185                 190         


Glu Arg Gln Glu Leu Gly Ser Pro Glu Glu Arg Leu Gln Asp Ser Ser 
        195                 200                 205             


Asp Pro Asp Xaa Gly Ser Glu Glu Glu Gly Ser Ser Arg Leu Ser Pro 
    210                 215                 220                 


Pro His Ser Pro Arg Gly Glu Xaa Leu Ala Glu Xaa Trp Xaa Arg Asp 
225                 230                 235                 240 


Phe Xaa Arg Met Gln Asp Ile Pro Glu Glu Xaa Glu Ser Arg Asp Gly 
                245                 250                 255     


Glu Ala Val Ala Ser Glu Ser 
            260             


<210> 2999
<211> 619
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<400> 2999
Met Lys Pro Pro Asp Arg Pro Ala Pro Gly Arg Xaa Asp Arg Ile Leu 
1               5                   10                  15      


Gly Val Met Gly Gly Met Leu Arg Ala Cys Ala Leu Pro Gly Gln Glu 
            20                  25                  30          


Gly Pro Pro Arg Arg Ser Pro Leu Gly Leu Val Gly Xaa Glu Pro Glu 
        35                  40                  45              


Ser Glu Arg Xaa Glu Gly Asp His Arg Arg Asp Arg Glu His Glu Val 
    50                  55                  60                  


Leu Ala Gly Ala Leu Gln Pro Glu Ser Tyr Ser Ile Ala Gly Ser Glu 
65                  70                  75                  80  


Gly Ser Ile Ser Ala Ser Ala Ala Ser Gly Leu Ala Ala Pro Ser Gly 
                85                  90                  95      


Pro Ser Ser Gly Leu Ser Ser Gly Pro Cys Ser Pro Gly Pro Pro Gly 
            100                 105                 110         


Pro Val Ser Gly Leu Arg Arg Trp Leu Asp His Ser Lys His Cys Leu 
        115                 120                 125             


Ser Val Glu Xaa Glu Ala Asp Ser Gly Gln Ala Gly Pro Tyr Glu Asn 
    130                 135                 140                 


Trp Met Leu Glu Pro Ala Leu Ala Xaa Gly Glu Glu Leu Pro Glu Leu 
145                 150                 155                 160 


Xaa Leu Leu Xaa Xaa Leu Leu Glu Gly Pro Gly Asp Lys Xaa Gln Pro 
                165                 170                 175     


Pro Glu Glu Glu Xaa Leu Ser Gln Ala Pro Glu Ser Glu Glu Glu Gln 
            180                 185                 190         


Lys Lys Lys Ala Leu Glu Arg Ser Met Tyr Val Leu Ser Glu Leu Val 
        195                 200                 205             


Glu Xaa Glu Lys Met Tyr Val Asp Asp Leu Gly Gln Ile Val Glu Gly 
    210                 215                 220                 


Tyr Met Ala Xaa Met Ala Ala Gln Gly Val Pro Glu Ser Leu Arg Gly 
225                 230                 235                 240 


Arg Asp Arg Ile Val Phe Gly Asn Ile Gln Gln Ile Tyr Glu Trp His 
                245                 250                 255     


Arg Asp Tyr Phe Leu Gln Glu Leu Gln Arg Cys Leu Lys Asp Pro Asp 
            260                 265                 270         


Trp Leu Ala Gln Leu Phe Ile Lys His Glu Arg Arg Leu His Met Tyr 
        275                 280                 285             


Val Val Tyr Cys Gln Asn Lys Pro Lys Ser Glu His Val Val Ser Glu 
    290                 295                 300                 


Phe Gly Asp Ser Tyr Phe Glu Glu Leu Arg Gln Gln Leu Gly His Arg 
305                 310                 315                 320 


Leu Gln Leu Asn Asp Leu Leu Ile Lys Pro Val Gln Arg Ile Met Lys 
                325                 330                 335     


Tyr Gln Leu Leu Leu Lys Asp Phe Leu Lys Tyr Tyr Asn Arg Ala Gly 
            340                 345                 350         


Met Asp Xaa Ala Asp Leu Glu Gln Ala Val Glu Val Met Cys Phe Val 
        355                 360                 365             


Pro Lys Arg Cys Asn Asp Met Met Xaa Leu Gly Arg Leu Arg Gly Phe 
    370                 375                 380                 


Glu Gly Lys Leu Xaa Ala Gln Gly Lys Leu Leu Gly Gln Asp Xaa Phe 
385                 390                 395                 400 


Trp Val Xaa Glu Pro Glu Ala Gly Gly Leu Leu Ser Ser Arg Gly Arg 
                405                 410                 415     


Glu Arg Arg Val Phe Leu Phe Glu Gln Ile Ile Ile Phe Ser Glu Ala 
            420                 425                 430         


Leu Gly Gly Gly Val Arg Gly Gly Xaa Gln Pro Gly Tyr Val Tyr Lys 
        435                 440                 445             


Asn Ser Ile Lys Val Ser Cys Leu Gly Leu Glu Gly Asn Leu Gln Gly 
    450                 455                 460                 


Asp Pro Cys Arg Phe Ala Leu Xaa Ser Arg Gly Pro Glu Gly Gly Ile 
465                 470                 475                 480 


Gln Arg Tyr Val Leu Gln Ala Ala Asp Pro Ala Ile Ser Gln Ala Trp 
                485                 490                 495     


Ile Lys His Val Ala Gln Ile Leu Glu Ser Gln Arg Asp Phe Leu Asn 
            500                 505                 510         


Ala Leu Gln Ser Pro Ile Glu Tyr Gln Arg Arg Glu Ser Gln Xaa Asn 
        515                 520                 525             


Ser Leu Gly Arg Pro Arg Gly Pro Gly Val Gly Ser Pro Gly Arg Ile 
    530                 535                 540                 


Gln Leu Gly Asp Gln Ala Gln Gly Ser Xaa His Xaa Pro Ile Asn Gly 
545                 550                 555                 560 


Ser Leu Pro Ser Leu Leu Leu Ser Pro Lys Gly Glu Val Ala Arg Ala 
                565                 570                 575     


Leu Leu Pro Leu Asp Lys Gln Ala Leu Gly Asp Ile Pro Gln Ala Pro 
            580                 585                 590         


His Asp Ser Pro Pro Val Ser Pro Xaa Pro Lys Xaa Pro Pro Cys Gln 
        595                 600                 605             


Ala Arg Leu Ala Lys Leu Asp Glu Asp Glu Leu 
    610                 615                 


<210> 3000
<211> 474
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<400> 3000
Met Leu Glu Pro Ala Leu Ala Xaa Gly Glu Glu Leu Pro Glu Leu Xaa 
1               5                   10                  15      


Leu Leu Xaa Xaa Leu Leu Glu Gly Pro Gly Asp Lys Xaa Gln Pro Pro 
            20                  25                  30          


Glu Glu Glu Xaa Leu Ser Gln Ala Pro Glu Ser Glu Glu Glu Gln Lys 
        35                  40                  45              


Lys Lys Ala Leu Glu Arg Ser Met Tyr Val Leu Ser Glu Leu Val Glu 
    50                  55                  60                  


Xaa Glu Lys Met Tyr Val Asp Asp Leu Gly Gln Ile Val Glu Gly Tyr 
65                  70                  75                  80  


Met Ala Xaa Met Ala Ala Gln Gly Val Pro Glu Ser Leu Arg Gly Arg 
                85                  90                  95      


Asp Arg Ile Val Phe Gly Asn Ile Gln Gln Ile Tyr Glu Trp His Arg 
            100                 105                 110         


Asp Tyr Phe Leu Gln Glu Leu Gln Arg Cys Leu Lys Asp Pro Asp Trp 
        115                 120                 125             


Leu Ala Gln Leu Phe Ile Lys His Glu Arg Arg Leu His Met Tyr Val 
    130                 135                 140                 


Val Tyr Cys Gln Asn Lys Pro Lys Ser Glu His Val Val Ser Glu Phe 
145                 150                 155                 160 


Gly Asp Ser Tyr Phe Glu Glu Leu Arg Gln Gln Leu Gly His Arg Leu 
                165                 170                 175     


Gln Leu Asn Asp Leu Leu Ile Lys Pro Val Gln Arg Ile Met Lys Tyr 
            180                 185                 190         


Gln Leu Leu Leu Lys Asp Phe Leu Lys Tyr Tyr Asn Arg Ala Gly Met 
        195                 200                 205             


Asp Xaa Ala Asp Leu Glu Gln Ala Val Glu Val Met Cys Phe Val Pro 
    210                 215                 220                 


Lys Arg Cys Asn Asp Met Met Xaa Leu Gly Arg Leu Arg Gly Phe Glu 
225                 230                 235                 240 


Gly Lys Leu Xaa Ala Gln Gly Lys Leu Leu Gly Gln Asp Xaa Phe Trp 
                245                 250                 255     


Val Xaa Glu Pro Glu Ala Gly Gly Leu Leu Ser Ser Arg Gly Arg Glu 
            260                 265                 270         


Arg Arg Val Phe Leu Phe Glu Gln Ile Ile Ile Phe Ser Glu Ala Leu 
        275                 280                 285             


Gly Gly Gly Val Arg Gly Gly Xaa Gln Pro Gly Tyr Val Tyr Lys Asn 
    290                 295                 300                 


Ser Ile Lys Val Ser Cys Leu Gly Leu Glu Gly Asn Leu Gln Gly Asp 
305                 310                 315                 320 


Pro Cys Arg Phe Ala Leu Xaa Ser Arg Gly Pro Glu Gly Gly Ile Gln 
                325                 330                 335     


Arg Tyr Val Leu Gln Ala Ala Asp Pro Ala Ile Ser Gln Ala Trp Ile 
            340                 345                 350         


Lys His Val Ala Gln Ile Leu Glu Ser Gln Arg Asp Phe Leu Asn Ala 
        355                 360                 365             


Leu Gln Ser Pro Ile Glu Tyr Gln Arg Arg Glu Ser Gln Xaa Asn Ser 
    370                 375                 380                 


Leu Gly Arg Pro Arg Gly Pro Gly Val Gly Ser Pro Gly Arg Ile Gln 
385                 390                 395                 400 


Leu Gly Asp Gln Ala Gln Gly Ser Xaa His Xaa Pro Ile Asn Gly Ser 
                405                 410                 415     


Leu Pro Ser Leu Leu Leu Ser Pro Lys Gly Glu Val Ala Arg Ala Leu 
            420                 425                 430         


Leu Pro Leu Asp Lys Gln Ala Leu Gly Asp Ile Pro Gln Ala Pro His 
        435                 440                 445             


Asp Ser Pro Pro Val Ser Pro Xaa Pro Lys Xaa Pro Pro Cys Gln Ala 
    450                 455                 460                 


Arg Leu Ala Lys Leu Asp Glu Asp Glu Leu 
465                 470                 


<210> 3001
<211> 580
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<400> 3001
Met Arg Gly Gly His Lys Gly Gly Arg Cys Ala Cys Pro Arg Val Ile 
1               5                   10                  15      


Arg Lys Val Leu Ala Lys Cys Gly Cys Cys Phe Ala Arg Gly Gly Arg 
            20                  25                  30          


Glu Ser Tyr Ser Ile Ala Gly Ser Glu Gly Ser Ile Ser Ala Ser Ala 
        35                  40                  45              


Ala Ser Gly Leu Ala Ala Pro Ser Gly Pro Ser Ser Gly Leu Ser Ser 
    50                  55                  60                  


Gly Pro Cys Ser Pro Gly Pro Pro Gly Pro Val Ser Gly Leu Arg Arg 
65                  70                  75                  80  


Trp Leu Asp His Ser Lys His Cys Leu Ser Val Glu Xaa Glu Ala Asp 
                85                  90                  95      


Ser Gly Gln Ala Gly Pro Tyr Glu Asn Trp Met Leu Glu Pro Ala Leu 
            100                 105                 110         


Ala Xaa Gly Glu Glu Leu Pro Glu Leu Xaa Leu Leu Xaa Xaa Leu Leu 
        115                 120                 125             


Glu Gly Pro Gly Asp Lys Xaa Gln Pro Pro Glu Glu Glu Xaa Leu Ser 
    130                 135                 140                 


Gln Ala Pro Glu Ser Glu Glu Glu Gln Lys Lys Lys Ala Leu Glu Arg 
145                 150                 155                 160 


Ser Met Tyr Val Leu Ser Glu Leu Val Glu Xaa Glu Lys Met Tyr Val 
                165                 170                 175     


Asp Asp Leu Gly Gln Ile Val Glu Gly Tyr Met Ala Xaa Met Ala Ala 
            180                 185                 190         


Gln Gly Val Pro Glu Ser Leu Arg Gly Arg Asp Arg Ile Val Phe Gly 
        195                 200                 205             


Asn Ile Gln Gln Ile Tyr Glu Trp His Arg Asp Tyr Phe Leu Gln Glu 
    210                 215                 220                 


Leu Gln Arg Cys Leu Lys Asp Pro Asp Trp Leu Ala Gln Leu Phe Ile 
225                 230                 235                 240 


Lys His Glu Arg Arg Leu His Met Tyr Val Val Tyr Cys Gln Asn Lys 
                245                 250                 255     


Pro Lys Ser Glu His Val Val Ser Glu Phe Gly Asp Ser Tyr Phe Glu 
            260                 265                 270         


Glu Leu Arg Gln Gln Leu Gly His Arg Leu Gln Leu Asn Asp Leu Leu 
        275                 280                 285             


Ile Lys Pro Val Gln Arg Ile Met Lys Tyr Gln Leu Leu Leu Lys Asp 
    290                 295                 300                 


Phe Leu Lys Tyr Tyr Asn Arg Ala Gly Met Asp Xaa Ala Asp Leu Glu 
305                 310                 315                 320 


Gln Ala Val Glu Val Met Cys Phe Val Pro Lys Arg Cys Asn Asp Met 
                325                 330                 335     


Met Xaa Leu Gly Arg Leu Arg Gly Phe Glu Gly Lys Leu Xaa Ala Gln 
            340                 345                 350         


Gly Lys Leu Leu Gly Gln Asp Xaa Phe Trp Val Xaa Glu Pro Glu Ala 
        355                 360                 365             


Gly Gly Leu Leu Ser Ser Arg Gly Arg Glu Arg Arg Val Phe Leu Phe 
    370                 375                 380                 


Glu Gln Ile Ile Ile Phe Ser Glu Ala Leu Gly Gly Gly Val Arg Gly 
385                 390                 395                 400 


Gly Xaa Gln Pro Gly Tyr Val Tyr Lys Asn Ser Ile Lys Val Ser Cys 
                405                 410                 415     


Leu Gly Leu Glu Gly Asn Leu Gln Gly Asp Pro Cys Arg Phe Ala Leu 
            420                 425                 430         


Xaa Ser Arg Gly Pro Glu Gly Gly Ile Gln Arg Tyr Val Leu Gln Ala 
        435                 440                 445             


Ala Asp Pro Ala Ile Ser Gln Ala Trp Ile Lys His Val Ala Gln Ile 
    450                 455                 460                 


Leu Glu Ser Gln Arg Asp Phe Leu Asn Ala Leu Gln Ser Pro Ile Glu 
465                 470                 475                 480 


Tyr Gln Arg Arg Glu Ser Gln Xaa Asn Ser Leu Gly Arg Pro Arg Gly 
                485                 490                 495     


Pro Gly Val Gly Ser Pro Gly Arg Ile Gln Leu Gly Asp Gln Ala Gln 
            500                 505                 510         


Gly Ser Xaa His Xaa Pro Ile Asn Gly Ser Leu Pro Ser Leu Leu Leu 
        515                 520                 525             


Ser Pro Lys Gly Glu Val Ala Arg Ala Leu Leu Pro Leu Asp Lys Gln 
    530                 535                 540                 


Ala Leu Gly Asp Ile Pro Gln Ala Pro His Asp Ser Pro Pro Val Ser 
545                 550                 555                 560 


Pro Xaa Pro Lys Xaa Pro Pro Cys Gln Ala Arg Leu Ala Lys Leu Asp 
                565                 570                 575     


Glu Asp Glu Leu 
            580 


<210> 3002
<211> 446
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<400> 3002
Met Asp Gly Glu Ser Glu Val Asp Phe Ser Ser Asn Ser Ile Xaa Pro 
1               5                   10                  15      


Leu Trp Arg Arg Arg Ser Ile Pro Gln Pro His Gln Val Leu Gly Arg 
            20                  25                  30          


Ser Lys Pro Arg Pro Gln Ser Tyr Gln Ser Pro Asn Gly Leu Leu Ile 
        35                  40                  45              


Xaa Asp Phe Pro Val Glu Asp Gly Gly Xaa Leu Leu Ala Ala Gln Ile 
    50                  55                  60                  


Pro Ala Gln Val Pro Xaa Ala Ser Asp Ser Arg Xaa Val His Arg Ser 
65                  70                  75                  80  


Pro Leu Leu Leu Gly Ala Gln Arg Arg Ala Val Ala Asn Gly Gly Xaa 
                85                  90                  95      


Ala Ser Pro Glu Tyr Arg Ala Ala Ser Pro Arg Leu Arg Arg Pro Lys 
            100                 105                 110         


Ser Pro Lys Leu Pro Lys Ala Val Pro Gly Gly Ser Pro Lys Ser Pro 
        115                 120                 125             


Ala Asn Gly Ala Val Xaa Leu Pro Ala Pro Pro Pro Pro Pro Val Leu 
    130                 135                 140                 


Arg Pro Pro Arg Xaa Pro Asn Ala Pro Ala Pro Cys Xaa Pro Glu Glu 
145                 150                 155                 160 


Asp Leu Xaa Gly Leu Xaa Ala Ser Pro Val Pro Ser Pro Xaa Ala Asn 
                165                 170                 175     


Gly Leu Ala Ala Asn Asn Asp Ser Pro Gly Ser Gly Ser Gln Ser Gly 
            180                 185                 190         


Arg Lys Ala Lys Asp Pro Glu Arg Gly Leu Phe Pro Gly Pro Gln Lys 
        195                 200                 205             


Ser Ser Ser Glu Gln Lys Leu Pro Leu Gln Arg Leu Pro Ser Gln Glu 
    210                 215                 220                 


Asn Glu Leu Leu Glu Asn Pro Ser Val Val Leu Ser Xaa Asn Ser Pro 
225                 230                 235                 240 


Ala Ala Leu Lys Val Gly Lys Gln Gln Ile Ile Pro Lys Ser Leu Ala 
                245                 250                 255     


Ser Glu Ile Lys Ile Ser Lys Ser Asn Asn Gln Asn Val Glu Pro His 
            260                 265                 270         


Lys Arg Leu Leu Lys Val Arg Ser Met Val Glu Gly Leu Gly Gly Pro 
        275                 280                 285             


Leu Gly His Ala Gly Glu Glu Ser Glu Val Asp Asn Asp Val Asp Ser 
    290                 295                 300                 


Pro Gly Ser Leu Arg Arg Gly Leu Arg Ser Xaa Ser Tyr Arg Arg Ala 
305                 310                 315                 320 


Val Val Ser Gly Phe Asp Phe Asp Ser Pro Xaa Ser Ser Lys Lys Lys 
                325                 330                 335     


Asn Arg Met Ser Gln Pro Val Leu Lys Val Val Met Glu Asp Lys Glu 
            340                 345                 350         


Lys Phe Ser Ser Leu Gly Arg Ile Lys Lys Lys Met Leu Lys Gly Gln 
        355                 360                 365             


Gly Xaa Phe Asp Gly Glu Glu Asn Ala Val Leu Tyr Gln Asn Tyr Lys 
    370                 375                 380                 


Glu Lys Ala Leu Asp Ile Asp Ser Asp Glu Glu Ser Glu Pro Lys Glu 
385                 390                 395                 400 


Gln Lys Ser Asp Glu Lys Ile Val Ile His His Lys Pro Leu Arg Ser 
                405                 410                 415     


Xaa Trp Ser Gln Leu Ser Ala Val Lys Arg Lys Val Ile Leu Ile Val 
            420                 425                 430         


Gly Phe Met Glu Met Lys Asp Gly Arg Leu Arg Gly Gly Lys 
        435                 440                 445     


<210> 3003
<211> 791
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<400> 3003
Met Asp Gly Glu Ser Glu Val Asp Phe Ser Ser Asn Ser Ile Xaa Pro 
1               5                   10                  15      


Leu Trp Arg Arg Arg Ser Ile Pro Gln Pro His Gln Val Leu Gly Arg 
            20                  25                  30          


Ser Lys Pro Arg Pro Gln Ser Tyr Gln Ser Pro Asn Gly Leu Leu Ile 
        35                  40                  45              


Xaa Asp Phe Pro Val Glu Asp Gly Gly Xaa Leu Leu Ala Ala Gln Ile 
    50                  55                  60                  


Pro Ala Gln Val Pro Xaa Ala Ser Asp Ser Arg Xaa Val His Arg Ser 
65                  70                  75                  80  


Pro Leu Leu Leu Gly Ala Gln Arg Arg Ala Val Ala Asn Gly Gly Xaa 
                85                  90                  95      


Ala Ser Pro Glu Tyr Arg Ala Ala Ser Pro Arg Leu Arg Arg Pro Lys 
            100                 105                 110         


Ser Pro Lys Leu Pro Lys Ala Val Pro Gly Gly Ser Pro Lys Ser Pro 
        115                 120                 125             


Ala Asn Gly Ala Val Xaa Leu Pro Ala Pro Pro Pro Pro Pro Val Leu 
    130                 135                 140                 


Arg Pro Pro Arg Xaa Pro Asn Ala Pro Ala Pro Cys Xaa Pro Glu Glu 
145                 150                 155                 160 


Asp Leu Xaa Gly Leu Xaa Ala Ser Pro Val Pro Ser Pro Xaa Ala Asn 
                165                 170                 175     


Gly Leu Ala Ala Asn Asn Asp Ser Pro Gly Ser Gly Ser Gln Ser Gly 
            180                 185                 190         


Arg Lys Ala Lys Asp Pro Glu Arg Gly Leu Phe Pro Gly Pro Gln Lys 
        195                 200                 205             


Ser Ser Ser Glu Gln Lys Leu Pro Leu Gln Arg Leu Pro Ser Gln Glu 
    210                 215                 220                 


Asn Glu Leu Leu Glu Asn Pro Ser Val Val Leu Ser Xaa Asn Ser Pro 
225                 230                 235                 240 


Ala Ala Leu Lys Val Gly Lys Gln Gln Ile Ile Pro Lys Ser Leu Ala 
                245                 250                 255     


Ser Glu Ile Lys Ile Ser Lys Ser Asn Asn Gln Asn Val Glu Pro His 
            260                 265                 270         


Lys Arg Leu Leu Lys Val Arg Ser Met Val Glu Gly Leu Gly Gly Pro 
        275                 280                 285             


Leu Gly His Ala Gly Glu Glu Ser Glu Val Asp Asn Asp Val Asp Ser 
    290                 295                 300                 


Pro Gly Ser Leu Arg Arg Gly Leu Arg Ser Xaa Ser Tyr Arg Arg Ala 
305                 310                 315                 320 


Val Val Ser Gly Phe Asp Phe Asp Ser Pro Xaa Ser Ser Lys Lys Lys 
                325                 330                 335     


Asn Arg Met Ser Gln Pro Val Leu Lys Val Val Met Glu Asp Lys Glu 
            340                 345                 350         


Lys Phe Ser Ser Leu Gly Arg Ile Lys Lys Lys Met Leu Lys Gly Gln 
        355                 360                 365             


Gly Xaa Phe Asp Gly Glu Glu Asn Ala Val Leu Tyr Gln Asn Tyr Lys 
    370                 375                 380                 


Glu Lys Ala Leu Asp Ile Asp Ser Asp Glu Glu Ser Glu Pro Lys Glu 
385                 390                 395                 400 


Gln Lys Ser Asp Glu Lys Ile Val Ile His His Lys Pro Leu Arg Ser 
                405                 410                 415     


Xaa Trp Ser Gln Leu Ser Ala Val Lys Arg Lys Gly Leu Ser Gln Xaa 
            420                 425                 430         


Val Ser Gln Glu Glu Arg Lys Arg Gln Glu Ala Ile Phe Glu Val Ile 
        435                 440                 445             


Ser Ser Glu His Ser Tyr Leu Leu Ser Leu Glu Ile Leu Ile Arg Met 
    450                 455                 460                 


Phe Lys Asn Ser Lys Glu Leu Ser Asp Xaa Met Xaa Lys Xaa Glu Arg 
465                 470                 475                 480 


His His Leu Phe Ser Asn Ile Xaa Asp Val Cys Glu Ala Ser Lys Lys 
                485                 490                 495     


Phe Phe Ile Glu Leu Glu Ala Arg His Gln Asn Asn Ile Phe Ile Asp 
            500                 505                 510         


Asp Ile Ser Asp Ile Val Glu Lys His Xaa Ala Ser Xaa Phe Asp Pro 
        515                 520                 525             


Tyr Val Lys Tyr Cys Xaa Asn Glu Val Tyr Gln Gln Arg Xaa Leu Gln 
    530                 535                 540                 


Lys Leu Leu Ala Xaa Asn Pro Ser Phe Lys Glu Val Leu Ser Arg Ile 
545                 550                 555                 560 


Glu Ser His Glu Asp Cys Arg Asn Leu Pro Met Ile Ser Phe Leu Ile 
                565                 570                 575     


Leu Pro Met Gln Arg Val Xaa Arg Leu Pro Leu Leu Met Asp Xaa Ile 
            580                 585                 590         


Cys Gln Lys Xaa Pro Lys Asp Ser Pro Lys Tyr Glu Val Cys Lys Arg 
        595                 600                 605             


Ala Leu Lys Glu Val Ser Lys Leu Val Arg Leu Cys Asn Glu Gly Ala 
    610                 615                 620                 


Arg Lys Met Glu Arg Xaa Glu Met Met Tyr Xaa Ile Asn Ser Gln Leu 
625                 630                 635                 640 


Glu Phe Lys Ile Lys Pro Phe Pro Leu Val Ser Ser Ser Arg Trp Leu 
                645                 650                 655     


Val Lys Arg Gly Glu Leu Xaa Ala Tyr Val Glu Asp Xaa Val Leu Phe 
            660                 665                 670         


Ser Arg Arg Xaa Ser Lys Gln Gln Val Tyr Phe Phe Leu Phe Asn Asp 
        675                 680                 685             


Val Leu Ile Ile Xaa Lys Lys Lys Ser Glu Glu Ser Tyr Asn Val Asn 
    690                 695                 700                 


Asp Tyr Ser Leu Arg Asp Gln Leu Leu Val Glu Ser Cys Asp Asn Glu 
705                 710                 715                 720 


Glu Leu Asn Ser Ser Pro Gly Lys Asn Ser Ser Xaa Met Leu Tyr Ser 
                725                 730                 735     


Arg Gln Ser Ser Ala Ser His Leu Phe Xaa Leu Xaa Val Leu Ser Asn 
            740                 745                 750         


His Ala Asn Glu Lys Val Glu Met Leu Leu Gly Ala Glu Xaa Gln Ser 
        755                 760                 765             


Glu Arg Ala Arg Trp Ile Xaa Ala Leu Gly His Ser Ser Gly Lys Pro 
    770                 775                 780                 


Pro Ala Asp Arg Xaa Cys Gly 
785                 790     


<210> 3004
<211> 871
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<400> 3004
Met Asp Gly Glu Ser Glu Val Asp Phe Ser Ser Asn Ser Ile Xaa Pro 
1               5                   10                  15      


Leu Trp Arg Arg Arg Ser Ile Pro Gln Pro His Gln Val Leu Gly Arg 
            20                  25                  30          


Ser Lys Pro Arg Pro Gln Ser Tyr Gln Ser Pro Asn Gly Leu Leu Ile 
        35                  40                  45              


Xaa Asp Phe Pro Val Glu Asp Gly Gly Xaa Leu Leu Ala Ala Gln Ile 
    50                  55                  60                  


Pro Ala Gln Val Pro Xaa Ala Ser Asp Ser Arg Xaa Val His Arg Ser 
65                  70                  75                  80  


Pro Leu Leu Leu Gly Ala Gln Arg Arg Ala Val Ala Asn Gly Gly Xaa 
                85                  90                  95      


Ala Ser Pro Glu Tyr Arg Ala Ala Ser Pro Arg Leu Arg Arg Pro Lys 
            100                 105                 110         


Ser Pro Lys Leu Pro Lys Ala Val Pro Gly Gly Ser Pro Lys Ser Pro 
        115                 120                 125             


Ala Asn Gly Ala Val Xaa Leu Pro Ala Pro Pro Pro Pro Pro Val Leu 
    130                 135                 140                 


Arg Pro Pro Arg Xaa Pro Asn Ala Pro Ala Pro Cys Xaa Pro Glu Glu 
145                 150                 155                 160 


Asp Leu Xaa Gly Leu Xaa Ala Ser Pro Val Pro Ser Pro Xaa Ala Asn 
                165                 170                 175     


Gly Leu Ala Ala Asn Asn Asp Ser Pro Gly Ser Gly Ser Gln Ser Gly 
            180                 185                 190         


Arg Lys Ala Lys Asp Pro Glu Arg Gly Leu Phe Pro Gly Pro Gln Lys 
        195                 200                 205             


Ser Ser Ser Glu Gln Lys Leu Pro Leu Gln Arg Leu Pro Ser Gln Glu 
    210                 215                 220                 


Asn Glu Leu Leu Glu Asn Pro Ser Val Val Leu Ser Xaa Asn Ser Pro 
225                 230                 235                 240 


Ala Ala Leu Lys Val Gly Lys Gln Gln Ile Ile Pro Lys Ser Leu Ala 
                245                 250                 255     


Ser Glu Ile Lys Ile Ser Lys Ser Asn Asn Gln Asn Val Glu Pro His 
            260                 265                 270         


Lys Arg Leu Leu Lys Val Arg Ser Met Val Glu Gly Leu Gly Gly Pro 
        275                 280                 285             


Leu Gly His Ala Gly Glu Glu Ser Glu Val Asp Asn Asp Val Asp Ser 
    290                 295                 300                 


Pro Gly Ser Leu Arg Arg Gly Leu Arg Ser Xaa Ser Tyr Arg Arg Ala 
305                 310                 315                 320 


Val Val Ser Gly Phe Asp Phe Asp Ser Pro Xaa Ser Ser Lys Lys Lys 
                325                 330                 335     


Asn Arg Met Ser Gln Pro Val Leu Lys Val Val Met Glu Asp Lys Glu 
            340                 345                 350         


Lys Phe Ser Ser Leu Gly Arg Ile Lys Lys Lys Met Leu Lys Gly Gln 
        355                 360                 365             


Gly Xaa Phe Asp Gly Glu Glu Asn Ala Val Leu Tyr Gln Asn Tyr Lys 
    370                 375                 380                 


Glu Lys Ala Leu Asp Ile Asp Ser Asp Glu Glu Ser Glu Pro Lys Glu 
385                 390                 395                 400 


Gln Lys Ser Asp Glu Lys Ile Val Ile His His Lys Pro Leu Arg Ser 
                405                 410                 415     


Xaa Trp Ser Gln Leu Ser Ala Val Lys Arg Lys Gly Leu Ser Gln Xaa 
            420                 425                 430         


Val Ser Gln Glu Glu Arg Lys Arg Gln Glu Ala Ile Phe Glu Val Ile 
        435                 440                 445             


Ser Ser Glu His Ser Tyr Leu Leu Ser Leu Glu Ile Leu Ile Arg Met 
    450                 455                 460                 


Phe Lys Asn Ser Lys Glu Leu Ser Asp Xaa Met Xaa Lys Xaa Glu Arg 
465                 470                 475                 480 


His His Leu Phe Ser Asn Ile Xaa Asp Val Cys Glu Ala Ser Lys Lys 
                485                 490                 495     


Phe Phe Ile Glu Leu Glu Ala Arg His Gln Asn Asn Ile Phe Ile Asp 
            500                 505                 510         


Asp Ile Ser Asp Ile Val Glu Lys His Xaa Ala Ser Xaa Phe Asp Pro 
        515                 520                 525             


Tyr Val Lys Tyr Cys Xaa Asn Glu Val Tyr Gln Gln Arg Xaa Leu Gln 
    530                 535                 540                 


Lys Leu Leu Ala Xaa Asn Pro Ser Phe Lys Glu Val Leu Ser Arg Ile 
545                 550                 555                 560 


Glu Ser His Glu Asp Cys Arg Asn Leu Pro Met Ile Ser Phe Leu Ile 
                565                 570                 575     


Leu Pro Met Gln Arg Val Xaa Arg Leu Pro Leu Leu Met Asp Xaa Ile 
            580                 585                 590         


Cys Gln Lys Xaa Pro Lys Asp Ser Pro Lys Tyr Glu Val Cys Lys Arg 
        595                 600                 605             


Ala Leu Lys Glu Val Ser Lys Leu Val Arg Leu Cys Asn Glu Gly Ala 
    610                 615                 620                 


Arg Lys Met Glu Arg Xaa Glu Met Met Tyr Xaa Ile Asn Ser Gln Leu 
625                 630                 635                 640 


Glu Phe Lys Ile Lys Pro Phe Pro Leu Val Ser Ser Ser Arg Trp Leu 
                645                 650                 655     


Val Lys Arg Gly Glu Leu Xaa Ala Tyr Val Glu Asp Xaa Val Leu Phe 
            660                 665                 670         


Ser Arg Arg Xaa Ser Lys Gln Gln Val Tyr Phe Phe Leu Phe Asn Asp 
        675                 680                 685             


Val Leu Ile Ile Xaa Lys Lys Lys Ser Glu Glu Ser Tyr Asn Val Asn 
    690                 695                 700                 


Asp Tyr Ser Leu Arg Asp Gln Leu Leu Val Glu Ser Cys Asp Asn Glu 
705                 710                 715                 720 


Glu Leu Asn Ser Ser Pro Gly Lys Asn Ser Ser Xaa Met Leu Tyr Ser 
                725                 730                 735     


Arg Gln Ser Ser Ala Ser His Leu Phe Xaa Leu Xaa Val Leu Ser Asn 
            740                 745                 750         


His Ala Asn Glu Lys Val Glu Met Leu Leu Gly Ala Glu Xaa Gln Ser 
        755                 760                 765             


Glu Arg Ala Arg Trp Ile Xaa Ala Leu Gly His Ser Ser Gly Lys Pro 
    770                 775                 780                 


Pro Ala Asp Arg Xaa Ser Leu Xaa Gln Val Glu Ile Val Arg Ser Phe 
785                 790                 795                 800 


Xaa Ala Lys Gln Pro Asp Glu Leu Ser Leu Gln Val Ala Asp Val Val 
                805                 810                 815     


Leu Ile Tyr Gln Arg Val Ser Asp Gly Trp Tyr Glu Gly Glu Arg Leu 
            820                 825                 830         


Arg Asp Gly Glu Arg Gly Trp Phe Pro Met Glu Cys Ala Lys Glu Ile 
        835                 840                 845             


Xaa Cys Gln Ala Xaa Ile Asp Lys Asn Val Glu Arg Met Gly Arg Leu 
    850                 855                 860                 


Leu Gly Leu Glu Xaa Asn Val 
865                 870     


<210> 3005
<211> 1392
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1282)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1315)..(1315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1340)..(1340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1343)..(1343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1347)..(1347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1363)..(1363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1375)..(1375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<400> 3005
Met Asp Ser Asp Ser Asp Ser Pro Phe Asn Tyr Ser Trp Pro Ser Phe 
1               5                   10                  15      


Pro Lys Met Lys Ile Arg Arg Arg Xaa Ser Lys Gln Asp Arg Ser Phe 
            20                  25                  30          


Asp Ile Leu Lys Lys Ser Lys Pro Pro Ser Xaa Leu Leu Ala Ala Gly 
        35                  40                  45              


Arg Leu Ser Asp Met Leu Asn Gly Gly Asp Glu Val Tyr Ala Asn Cys 
    50                  55                  60                  


Met Val Ile Asp Gln Val Gly Asp Leu Asp Ile Ser Tyr Ile Asn Ile 
65                  70                  75                  80  


Glu Gly Ile Xaa Ala Xaa Xaa Ser Pro Glu Ser Arg Gly Cys Xaa Leu 
                85                  90                  95      


Trp Pro Gln Ser Ser Lys His Xaa Leu Pro Xaa Glu Xaa Ser Pro Ser 
            100                 105                 110         


Val Tyr Pro Leu Ser Glu Asn Val Glu Gly Xaa Ala His Xaa Glu Ala 
        115                 120                 125             


Gln Gln Ser Phe Met Ser Pro Ser Ser Ser Cys Ala Ser Asn Leu Asn 
    130                 135                 140                 


Leu Ser Phe Gly Trp His Gly Phe Glu Lys Glu Gln Ser His Leu Lys 
145                 150                 155                 160 


Lys Arg Ser Ser Ser Leu Asp Ala Leu Asp Ala Asp Ser Glu Gly Glu 
                165                 170                 175     


Gly His Ser Glu Pro Ser His Ile Cys Tyr Xaa Pro Gly Ser Gln Ser 
            180                 185                 190         


Ser Ser Arg Xaa Gly Ile Pro Ser Gly Asp Glu Leu Asp Ser Phe Glu 
        195                 200                 205             


Xaa Asn Xaa Glu Pro Asp Phe Asn Ile Ser Arg Ala Glu Ser Leu Pro 
    210                 215                 220                 


Leu Ser Ser Asn Leu Gln Ser Lys Glu Ser Leu Leu Ser Gly Val Arg 
225                 230                 235                 240 


Ser Arg Ser Tyr Ser Cys Ser Ser Pro Lys Ile Ser Leu Gly Lys Xaa 
                245                 250                 255     


Arg Leu Val Arg Glu Leu Xaa Val Cys Ser Ser Ser Glu Glu Gln Arg 
            260                 265                 270         


Ala Tyr Ser Leu Ser Glu Pro Pro Arg Glu Asn Arg Ile Gln Glu Glu 
        275                 280                 285             


Glu Trp Asp Lys Tyr Ile Ile Pro Ala Lys Ser Glu Ser Glu Lys Tyr 
    290                 295                 300                 


Lys Val Ser Arg Xaa Phe Ser Phe Leu Met Asn Arg Met Xaa Ser Pro 
305                 310                 315                 320 


Arg Asn Lys Ser Lys Xaa Lys Ser Lys Asp Ala Lys Asp Lys Glu Lys 
                325                 330                 335     


Leu Asn Arg His Gln Phe Ala Pro Gly Xaa Phe Ser Gly Val Leu Gln 
            340                 345                 350         


Cys Leu Val Cys Asp Lys Xaa Leu Leu Gly Lys Glu Ser Leu Gln Cys 
        355                 360                 365             


Ser Asn Cys Asn Ala Asn Val His Lys Gly Cys Lys Asp Ala Ala Pro 
    370                 375                 380                 


Ala Cys Xaa Lys Lys Phe Gln Glu Lys Tyr Asn Lys Asn Lys Pro Gln 
385                 390                 395                 400 


Xaa Ile Leu Gly Asn Ser Ser Phe Arg Asp Ile Pro Gln Pro Gly Leu 
                405                 410                 415     


Ser Leu His Pro Ser Ser Ser Val Pro Val Gly Leu Pro Xaa Gly Arg 
            420                 425                 430         


Arg Glu Xaa Val Gly Gln Val His Pro Leu Ser Arg Ser Val Pro Gly 
        435                 440                 445             


Xaa Xaa Leu Glu Ser Phe Arg Arg Ser Ala Xaa Ser Leu Glu Ser Glu 
    450                 455                 460                 


Ser Asp His Asn Ser Cys Arg Ser Arg Ser His Ser Asp Glu Leu Leu 
465                 470                 475                 480 


Gln Ser Met Gly Ser Ser Pro Ser Xaa Glu Ser Phe Ile Met Glu Asp 
                485                 490                 495     


Val Val Asp Ser Ser Leu Trp Ser Asp Leu Ser Ser Asp Ala Gln Glu 
            500                 505                 510         


Phe Glu Ala Glu Ser Trp Ser Leu Val Val Asp Pro Ser Phe Cys Asn 
        515                 520                 525             


Arg Gln Glu Lys Asp Val Ile Lys Arg Gln Asp Val Ile Phe Glu Leu 
    530                 535                 540                 


Met Gln Xaa Glu Met His His Ile Gln Xaa Leu Phe Ile Met Ser Glu 
545                 550                 555                 560 


Ile Phe Arg Lys Gly Met Lys Glu Glu Leu Gln Leu Asp His Ser Xaa 
                565                 570                 575     


Val Asp Lys Ile Phe Pro Cys Leu Asp Glu Leu Leu Glu Ile His Arg 
            580                 585                 590         


His Phe Phe Tyr Ser Met Lys Glu Arg Arg Gln Glu Ser Cys Ala Gly 
        595                 600                 605             


Ser Asp Arg Asn Phe Val Ile Asp Arg Ile Gly Asp Ile Leu Val Gln 
    610                 615                 620                 


Gln Phe Ser Glu Glu Asn Ala Ser Lys Met Lys Lys Ile Tyr Gly Glu 
625                 630                 635                 640 


Phe Cys Cys His His Lys Glu Ala Val Asn Leu Phe Lys Glu Leu Gln 
                645                 650                 655     


Gln Asn Lys Lys Phe Gln Asn Phe Ile Lys Leu Arg Asn Ser Asn Leu 
            660                 665                 670         


Leu Ala Arg Arg Arg Gly Ile Pro Glu Cys Ile Leu Leu Val Xaa Gln 
        675                 680                 685             


Arg Ile Xaa Lys Tyr Pro Val Leu Val Glu Arg Ile Leu Gln Tyr Xaa 
    690                 695                 700                 


Lys Glu Arg Xaa Glu Glu His Lys Asp Leu Arg Lys Ala Leu Cys Leu 
705                 710                 715                 720 


Ile Lys Asp Met Ile Ala Xaa Val Asp Leu Lys Val Asn Glu Tyr Glu 
                725                 730                 735     


Lys Asn Gln Lys Trp Leu Glu Ile Leu Asn Lys Ile Glu Asn Lys Xaa 
            740                 745                 750         


Tyr Xaa Lys Leu Lys Asn Gly His Val Phe Arg Lys Gln Ala Leu Met 
        755                 760                 765             


Ser Glu Glu Arg Xaa Leu Leu Tyr Asp Gly Leu Val Tyr Trp Lys Xaa 
    770                 775                 780                 


Ala Xaa Gly Arg Phe Lys Asp Ile Leu Ala Leu Leu Leu Xaa Asp Val 
785                 790                 795                 800 


Leu Leu Phe Leu Gln Glu Lys Asp Gln Lys Tyr Ile Phe Ala Ala Val 
                805                 810                 815     


Asp Gln Lys Pro Ser Val Ile Ser Leu Gln Lys Leu Ile Ala Arg Glu 
            820                 825                 830         


Val Ala Asn Glu Glu Arg Gly Met Phe Leu Ile Ser Ala Ser Ser Ala 
        835                 840                 845             


Gly Pro Glu Met Tyr Glu Ile His Xaa Asn Ser Lys Glu Glu Arg Asn 
    850                 855                 860                 


Asn Trp Met Arg Arg Ile Gln Gln Ala Val Glu Ser Cys Pro Glu Glu 
865                 870                 875                 880 


Lys Gly Gly Arg Xaa Ser Glu Ser Asp Glu Asp Lys Arg Lys Ala Glu 
                885                 890                 895     


Ala Arg Val Ala Lys Ile Gln Gln Cys Gln Glu Ile Leu Xaa Asn Gln 
            900                 905                 910         


Asp Gln Gln Ile Cys Ala Tyr Leu Glu Glu Lys Leu His Ile Tyr Ala 
        915                 920                 925             


Glu Leu Gly Glu Leu Ser Gly Phe Glu Asp Val His Leu Glu Pro His 
    930                 935                 940                 


Leu Leu Ile Lys Pro Asp Pro Gly Glu Pro Pro Gln Ala Ala Ser Leu 
945                 950                 955                 960 


Leu Ala Ala Ala Leu Lys Glu Ala Glu Ser Leu Gln Val Ala Val Lys 
                965                 970                 975     


Ala Ser Gln Met Gly Ala Val Ser Gln Ser Cys Glu Asp Ser Cys Gly 
            980                 985                 990         


Asp Ser Val Leu Ala Asp Xaa Leu  Ser Ser His Asp Val  Pro Gly Ser 
        995                 1000                 1005             


Pro Xaa  Ala Ser Leu Val Xaa  Gly Gly Arg Glu Gly  Arg Gly Cys 
    1010                 1015                 1020             


Ser Asp  Val Asp Pro Gly Ile  Gln Gly Val Val Xaa  Asp Leu Ala 
    1025                 1030                 1035             


Val Ser  Asp Ala Gly Glu Lys  Val Glu Cys Arg Asn  Phe Pro Gly 
    1040                 1045                 1050             


Ser Ser  Gln Ser Glu Ile Ile  Gln Ala Ile Gln Asn  Leu Xaa Arg 
    1055                 1060                 1065             


Leu Leu  Tyr Ser Leu Gln Ala  Ala Leu Xaa Ile Gln  Asp Ser His 
    1070                 1075                 1080             


Ile Glu  Ile His Arg Leu Val  Leu Gln Gln Gln Glu  Gly Leu Ser 
    1085                 1090                 1095             


Leu Gly  His Ser Ile Leu Arg  Gly Gly Pro Leu Gln  Asp Gln Lys 
    1100                 1105                 1110             


Ser Arg  Asp Ala Asp Arg Gln  His Glu Glu Leu Ala  Asn Val His 
    1115                 1120                 1125             


Gln Leu  Gln His Gln Leu Gln  Gln Glu Gln Arg Arg  Trp Leu Arg 
    1130                 1135                 1140             


Arg Cys  Glu Gln Gln Gln Arg  Ala Gln Ala Xaa Arg  Glu Ser Trp 
    1145                 1150                 1155             


Leu Gln  Glu Arg Glu Arg Glu  Cys Gln Ser Gln Glu  Glu Leu Leu 
    1160                 1165                 1170             


Leu Arg  Ser Arg Gly Glu Leu  Asp Leu Gln Leu Gln  Glu Tyr Gln 
    1175                 1180                 1185             


His Ser  Leu Glu Arg Leu Arg  Glu Gly Gln Arg Leu  Val Glu Arg 
    1190                 1195                 1200             


Glu Gln  Ala Arg Met Arg Ala  Gln Gln Ser Leu Leu  Gly His Trp 
    1205                 1210                 1215             


Lys His  Gly Arg Gln Arg Ser  Leu Pro Ala Val Leu  Leu Pro Gly 
    1220                 1225                 1230             


Gly Pro  Glu Val Met Glu Leu  Asn Arg Ser Glu Ser  Leu Cys His 
    1235                 1240                 1245             


Glu Asn  Ser Phe Phe Ile Asn  Glu Ala Leu Val Gln  Met Ser Phe 
    1250                 1255                 1260             


Asn Xaa  Phe Asn Lys Leu Asn  Pro Ser Val Ile His  Gln Asp Ala 
    1265                 1270                 1275             


Xaa Tyr  Pro Xaa Xaa Gln Ser  His Ser Asp Leu Val  Arg Xaa Ser 
    1280                 1285                 1290             


Glu His  Gln Val Asp Leu Lys  Val Asp Pro Ser Gln  Pro Ser Asn 
    1295                 1300                 1305             


Val Ser  His Lys Leu Trp Xaa  Ala Ala Gly Ser Gly  His Gln Ile 
    1310                 1315                 1320             


Leu Pro  Phe His Glu Ser Ser  Lys Asp Ser Cys Lys  Asn Asp Leu 
    1325                 1330                 1335             


Asp Xaa  Ser His Xaa Glu Ser  Pro Xaa Pro His Asp  Ser Asn Ser 
    1340                 1345                 1350             


His Arg  Pro Gln Leu Gln Ala  Phe Ile Xaa Glu Ala  Lys Leu Asn 
    1355                 1360                 1365             


Leu Pro  Xaa Arg Xaa Met Xaa  Arg Gln Asp Gly Glu  Xaa Gly Asp 
    1370                 1375                 1380             


Gly Ala  Lys Glu Asn Ile Val  Tyr Leu 
    1385                 1390         


<210> 3006
<211> 83
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<400> 3006
Met Glu Leu Ser Cys Ser Glu Ala Pro Leu Tyr Gly Gln Met Met Ile 
1               5                   10                  15      


Tyr Ala Lys Phe Asp Lys Asn Val Tyr Leu Pro Glu Asp Ala Glu Phe 
            20                  25                  30          


Tyr Phe Xaa Tyr Asp Gly Ser His Gln Arg His Val Met Ile Ala Glu 
        35                  40                  45              


Arg Ile Glu Asp Asn Val Leu Gln Ser Ser Val Pro Gly His Gly Leu 
    50                  55                  60                  


Gln Glu Xaa Val Xaa Val Ser Val Cys Leu Cys Ser Glu Gly Tyr Ser 
65                  70                  75                  80  


Pro Val Xaa 
            


<210> 3007
<211> 1651
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1017)..(1017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1323)..(1323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1328)..(1328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1380)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1391)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1467)..(1467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1578)..(1578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1592)..(1592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1595)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1605)..(1605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1628)..(1628)
<223> Selenocysteine

<400> 3007
Met Glu Leu Ser Cys Ser Glu Ala Pro Leu Tyr Gly Gln Met Met Ile 
1               5                   10                  15      


Tyr Ala Lys Phe Asp Lys Asn Val Tyr Leu Pro Glu Asp Ala Glu Phe 
            20                  25                  30          


Tyr Phe Xaa Tyr Asp Gly Ser His Gln Arg His Val Met Ile Ala Glu 
        35                  40                  45              


Arg Ile Glu Asp Asn Val Leu Gln Ser Ser Val Pro Gly His Gly Leu 
    50                  55                  60                  


Gln Glu Xaa Val Xaa Val Ser Val Cys Leu Cys Ser Glu Gly Tyr Ser 
65                  70                  75                  80  


Pro Val Xaa Met Gly Ser Gly Ser Val Xaa Tyr Val Asp Asn Met Ala 
                85                  90                  95      


Cys Arg Leu Ala Arg Leu Leu Val Xaa Gln Ala Asn Arg Leu Xaa Ala 
            100                 105                 110         


Cys Ser His Gln Xaa Leu Leu Xaa Pro Phe Ala Leu Xaa Ala Gly Ala 
        115                 120                 125             


Leu Pro Ala Leu Asp Glu Glu Leu Val Leu Ala Leu Xaa His Leu Glu 
    130                 135                 140                 


Leu Pro Leu Glu Trp Xaa Val Leu Gly Ser Ser Ser Leu Glu Val Ser 
145                 150                 155                 160 


Ser His Arg Glu Ser Leu Leu His Leu Ala Met Arg Trp Gly Leu Ala 
                165                 170                 175     


Lys Leu Ser Gln Phe Phe Leu Cys Leu Pro Gly Gly Val Gln Ala Leu 
            180                 185                 190         


Ala Leu Pro Asn Glu Glu Gly Ala Xaa Pro Leu Asp Leu Ala Leu Arg 
        195                 200                 205             


Glu Gly His Ser Lys Leu Val Glu Asp Val Xaa Asn Phe Gln Gly Arg 
    210                 215                 220                 


Trp Ser Pro Ser Phe Ser Arg Val Gln Leu Ser Glu Glu Ala Ser Leu 
225                 230                 235                 240 


His Tyr Ile His Ser Ser Glu Xaa Leu Xaa Leu Xaa Leu Asn His Xaa 
                245                 250                 255     


Ala Glu His Leu Leu Glu Ala Asp Ile Lys Leu Phe Arg Lys Tyr Phe 
            260                 265                 270         


Trp Asp Arg Ala Phe Leu Val Lys Ala Phe Glu Pro Glu Ala Arg Pro 
        275                 280                 285             


Glu Glu Arg Xaa Ala Met Pro Ser Ser Gly Ala Glu Xaa Glu Glu Glu 
    290                 295                 300                 


Ile Lys Asn Ser Val Ser Ser Arg Ser Ala Ala Glu Lys Glu Asp Ile 
305                 310                 315                 320 


Lys Arg Val Lys Ser Leu Val Val Gln His Asn Glu His Glu Asp Gln 
                325                 330                 335     


His Ser Leu Asp Leu Asp Arg Ser Phe Asp Ile Leu Lys Lys Ser Lys 
            340                 345                 350         


Pro Pro Ser Xaa Leu Leu Ala Ala Gly Arg Leu Ser Asp Met Leu Asn 
        355                 360                 365             


Gly Gly Asp Glu Val Tyr Ala Asn Cys Met Val Ile Asp Gln Val Gly 
    370                 375                 380                 


Asp Leu Asp Ile Ser Tyr Ile Asn Ile Glu Gly Ile Xaa Ala Xaa Xaa 
385                 390                 395                 400 


Ser Pro Glu Ser Arg Gly Cys Xaa Leu Trp Pro Gln Ser Ser Lys His 
                405                 410                 415     


Xaa Leu Pro Xaa Glu Xaa Ser Pro Ser Val Tyr Pro Leu Ser Glu Asn 
            420                 425                 430         


Val Glu Gly Xaa Ala His Xaa Glu Ala Gln Gln Ser Phe Met Ser Pro 
        435                 440                 445             


Ser Ser Ser Cys Ala Ser Asn Leu Asn Leu Ser Phe Gly Trp His Gly 
    450                 455                 460                 


Phe Glu Lys Glu Gln Ser His Leu Lys Lys Arg Ser Ser Ser Leu Asp 
465                 470                 475                 480 


Ala Leu Asp Ala Asp Ser Glu Gly Glu Gly His Ser Glu Pro Ser His 
                485                 490                 495     


Ile Cys Tyr Xaa Pro Gly Ser Gln Ser Ser Ser Arg Xaa Gly Ile Pro 
            500                 505                 510         


Ser Gly Asp Glu Leu Asp Ser Phe Glu Xaa Asn Xaa Glu Pro Asp Phe 
        515                 520                 525             


Asn Ile Ser Arg Ala Glu Ser Leu Pro Leu Ser Ser Asn Leu Gln Ser 
    530                 535                 540                 


Lys Glu Ser Leu Leu Ser Gly Val Arg Ser Arg Ser Tyr Ser Cys Ser 
545                 550                 555                 560 


Ser Pro Lys Ile Ser Leu Gly Lys Xaa Arg Leu Val Arg Glu Leu Xaa 
                565                 570                 575     


Val Cys Ser Ser Ser Glu Glu Gln Arg Ala Tyr Ser Leu Ser Glu Pro 
            580                 585                 590         


Pro Arg Glu Asn Arg Ile Gln Glu Glu Glu Trp Asp Lys Tyr Ile Ile 
        595                 600                 605             


Pro Ala Lys Ser Glu Ser Glu Lys Tyr Lys Val Ser Arg Xaa Phe Ser 
    610                 615                 620                 


Phe Leu Met Asn Arg Met Xaa Ser Pro Arg Asn Lys Ser Lys Xaa Lys 
625                 630                 635                 640 


Ser Lys Asp Ala Lys Asp Lys Glu Lys Leu Asn Arg His Gln Phe Ala 
                645                 650                 655     


Pro Gly Xaa Phe Ser Gly Val Leu Gln Cys Leu Val Cys Asp Lys Xaa 
            660                 665                 670         


Leu Leu Gly Lys Glu Ser Leu Gln Cys Ser Asn Cys Asn Ala Asn Val 
        675                 680                 685             


His Lys Gly Cys Lys Asp Ala Ala Pro Ala Cys Xaa Lys Lys Phe Gln 
    690                 695                 700                 


Glu Lys Tyr Asn Lys Asn Lys Pro Gln Xaa Ile Leu Gly Asn Ser Ser 
705                 710                 715                 720 


Phe Arg Asp Ile Pro Gln Pro Gly Leu Ser Leu His Pro Ser Ser Ser 
                725                 730                 735     


Val Pro Val Gly Leu Pro Xaa Gly Arg Arg Glu Xaa Val Gly Gln Val 
            740                 745                 750         


His Pro Leu Ser Arg Ser Val Pro Gly Xaa Xaa Leu Glu Ser Phe Arg 
        755                 760                 765             


Arg Ser Ala Xaa Ser Leu Glu Ser Glu Ser Asp His Asn Ser Cys Arg 
    770                 775                 780                 


Ser Arg Ser His Ser Asp Glu Leu Leu Gln Ser Met Gly Ser Ser Pro 
785                 790                 795                 800 


Ser Xaa Glu Ser Phe Ile Met Glu Asp Val Val Asp Ser Ser Leu Trp 
                805                 810                 815     


Ser Asp Leu Ser Ser Asp Ala Gln Glu Phe Glu Ala Glu Ser Trp Ser 
            820                 825                 830         


Leu Val Val Asp Pro Ser Phe Cys Asn Arg Gln Glu Lys Asp Val Ile 
        835                 840                 845             


Lys Arg Gln Asp Val Ile Phe Glu Leu Met Gln Xaa Glu Met His His 
    850                 855                 860                 


Ile Gln Xaa Leu Phe Ile Met Ser Glu Ile Phe Arg Lys Gly Met Lys 
865                 870                 875                 880 


Glu Glu Leu Gln Leu Asp His Ser Xaa Val Asp Lys Ile Phe Pro Cys 
                885                 890                 895     


Leu Asp Glu Leu Leu Glu Ile His Arg His Phe Phe Tyr Ser Met Lys 
            900                 905                 910         


Glu Arg Arg Gln Glu Ser Cys Ala Gly Ser Asp Arg Asn Phe Val Ile 
        915                 920                 925             


Asp Arg Ile Gly Asp Ile Leu Val Gln Gln Phe Ser Glu Glu Asn Ala 
    930                 935                 940                 


Ser Lys Met Lys Lys Ile Tyr Gly Glu Phe Cys Cys His His Lys Glu 
945                 950                 955                 960 


Ala Val Asn Leu Phe Lys Glu Leu Gln Gln Asn Lys Lys Phe Gln Asn 
                965                 970                 975     


Phe Ile Lys Leu Arg Asn Ser Asn Leu Leu Ala Arg Arg Arg Gly Ile 
            980                 985                 990         


Pro Glu Cys Ile Leu Leu Val Xaa  Gln Arg Ile Xaa Lys  Tyr Pro Val 
        995                 1000                 1005             


Leu Val  Glu Arg Ile Leu Gln  Tyr Xaa Lys Glu Arg  Xaa Glu Glu 
    1010                 1015                 1020             


His Lys  Asp Leu Arg Lys Ala  Leu Cys Leu Ile Lys  Asp Met Ile 
    1025                 1030                 1035             


Ala Xaa  Val Asp Leu Lys Val  Asn Glu Tyr Glu Lys  Asn Gln Lys 
    1040                 1045                 1050             


Trp Leu  Glu Ile Leu Asn Lys  Ile Glu Asn Lys Xaa  Tyr Xaa Lys 
    1055                 1060                 1065             


Leu Lys  Asn Gly His Val Phe  Arg Lys Gln Ala Leu  Met Ser Glu 
    1070                 1075                 1080             


Glu Arg  Xaa Leu Leu Tyr Asp  Gly Leu Val Tyr Trp  Lys Xaa Ala 
    1085                 1090                 1095             


Xaa Gly  Arg Phe Lys Asp Ile  Leu Ala Leu Leu Leu  Xaa Asp Val 
    1100                 1105                 1110             


Leu Leu  Phe Leu Gln Glu Lys  Asp Gln Lys Tyr Ile  Phe Ala Ala 
    1115                 1120                 1125             


Val Asp  Gln Lys Pro Ser Val  Ile Ser Leu Gln Lys  Leu Ile Ala 
    1130                 1135                 1140             


Arg Glu  Val Ala Asn Glu Glu  Arg Gly Met Phe Leu  Ile Ser Ala 
    1145                 1150                 1155             


Ser Ser  Ala Gly Pro Glu Met  Tyr Glu Ile His Xaa  Asn Ser Lys 
    1160                 1165                 1170             


Glu Glu  Arg Asn Asn Trp Met  Arg Arg Ile Gln Gln  Ala Val Glu 
    1175                 1180                 1185             


Ser Cys  Pro Glu Glu Lys Gly  Gly Arg Xaa Ser Glu  Ser Asp Glu 
    1190                 1195                 1200             


Asp Lys  Arg Lys Ala Glu Ala  Arg Val Ala Lys Ile  Gln Gln Cys 
    1205                 1210                 1215             


Gln Glu  Ile Leu Xaa Asn Gln  Asp Gln Gln Ile Cys  Ala Tyr Leu 
    1220                 1225                 1230             


Glu Glu  Lys Leu His Ile Tyr  Ala Glu Leu Gly Glu  Leu Ser Gly 
    1235                 1240                 1245             


Phe Glu  Asp Val His Leu Glu  Pro His Leu Leu Ile  Lys Pro Asp 
    1250                 1255                 1260             


Pro Gly  Glu Pro Pro Gln Ala  Ala Ser Leu Leu Ala  Ala Ala Leu 
    1265                 1270                 1275             


Lys Glu  Ala Glu Ser Leu Gln  Val Ala Val Lys Ala  Ser Gln Met 
    1280                 1285                 1290             


Gly Ala  Val Ser Gln Ser Cys  Glu Asp Ser Cys Gly  Asp Ser Val 
    1295                 1300                 1305             


Leu Ala  Asp Xaa Leu Ser Ser  His Asp Val Pro Gly  Ser Pro Xaa 
    1310                 1315                 1320             


Ala Ser  Leu Val Xaa Gly Gly  Arg Glu Gly Arg Gly  Cys Ser Asp 
    1325                 1330                 1335             


Val Asp  Pro Gly Ile Gln Gly  Val Val Xaa Asp Leu  Ala Val Ser 
    1340                 1345                 1350             


Asp Ala  Gly Glu Lys Val Glu  Cys Arg Asn Phe Pro  Gly Ser Ser 
    1355                 1360                 1365             


Gln Ser  Glu Ile Ile Gln Ala  Ile Gln Asn Leu Xaa  Arg Leu Leu 
    1370                 1375                 1380             


Tyr Ser  Leu Gln Ala Ala Leu  Xaa Ile Gln Asp Ser  His Ile Glu 
    1385                 1390                 1395             


Ile His  Arg Leu Val Leu Gln  Gln Gln Glu Gly Leu  Ser Leu Gly 
    1400                 1405                 1410             


His Ser  Ile Leu Arg Gly Gly  Pro Leu Gln Asp Gln  Lys Ser Arg 
    1415                 1420                 1425             


Asp Ala  Asp Arg Gln His Glu  Glu Leu Ala Asn Val  His Gln Leu 
    1430                 1435                 1440             


Gln His  Gln Leu Gln Gln Glu  Gln Arg Arg Trp Leu  Arg Arg Cys 
    1445                 1450                 1455             


Glu Gln  Gln Gln Arg Ala Gln  Ala Xaa Arg Glu Ser  Trp Leu Gln 
    1460                 1465                 1470             


Glu Arg  Glu Arg Glu Cys Gln  Ser Gln Glu Glu Leu  Leu Leu Arg 
    1475                 1480                 1485             


Ser Arg  Gly Glu Leu Asp Leu  Gln Leu Gln Glu Tyr  Gln His Ser 
    1490                 1495                 1500             


Leu Glu  Arg Leu Arg Glu Gly  Gln Arg Leu Val Glu  Arg Glu Gln 
    1505                 1510                 1515             


Ala Arg  Met Arg Ala Gln Gln  Ser Leu Leu Gly His  Trp Lys His 
    1520                 1525                 1530             


Gly Arg  Gln Arg Ser Leu Pro  Ala Val Leu Leu Pro  Gly Gly Pro 
    1535                 1540                 1545             


Glu Val  Met Glu Leu Asn Arg  Ser Glu Ser Leu Cys  His Glu Asn 
    1550                 1555                 1560             


Ser Phe  Phe Ile Asn Glu Ala  Leu Val Gln Met Ser  Phe Asn Xaa 
    1565                 1570                 1575             


Phe Asn  Lys Leu Asn Pro Ser  Val Ile His Gln Asp  Ala Xaa Tyr 
    1580                 1585                 1590             


Pro Xaa  Xaa Gln Ser His Ser  Asp Leu Val Arg Xaa  Ser Glu His 
    1595                 1600                 1605             


Gln Val  Asp Leu Lys Val Asp  Pro Ser Gln Pro Ser  Asn Val Ser 
    1610                 1615                 1620             


His Lys  Leu Trp Xaa Ala Ala  Gly Ser Gly His Gln  Ile Leu Pro 
    1625                 1630                 1635             


Phe His  Glu Ser Ser Lys Asp  Ser Cys Lys Asn Gly  Asn 
    1640                 1645                 1650     


<210> 3008
<211> 1705
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1017)..(1017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1323)..(1323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1328)..(1328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1380)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1391)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1467)..(1467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1578)..(1578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1592)..(1592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1595)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1605)..(1605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1628)..(1628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1653)..(1653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1656)..(1656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1660)..(1660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1676)..(1676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1684)..(1684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1686)..(1686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1688)..(1688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1694)..(1694)
<223> Selenocysteine

<400> 3008
Met Glu Leu Ser Cys Ser Glu Ala Pro Leu Tyr Gly Gln Met Met Ile 
1               5                   10                  15      


Tyr Ala Lys Phe Asp Lys Asn Val Tyr Leu Pro Glu Asp Ala Glu Phe 
            20                  25                  30          


Tyr Phe Xaa Tyr Asp Gly Ser His Gln Arg His Val Met Ile Ala Glu 
        35                  40                  45              


Arg Ile Glu Asp Asn Val Leu Gln Ser Ser Val Pro Gly His Gly Leu 
    50                  55                  60                  


Gln Glu Xaa Val Xaa Val Ser Val Cys Leu Cys Ser Glu Gly Tyr Ser 
65                  70                  75                  80  


Pro Val Xaa Met Gly Ser Gly Ser Val Xaa Tyr Val Asp Asn Met Ala 
                85                  90                  95      


Cys Arg Leu Ala Arg Leu Leu Val Xaa Gln Ala Asn Arg Leu Xaa Ala 
            100                 105                 110         


Cys Ser His Gln Xaa Leu Leu Xaa Pro Phe Ala Leu Xaa Ala Gly Ala 
        115                 120                 125             


Leu Pro Ala Leu Asp Glu Glu Leu Val Leu Ala Leu Xaa His Leu Glu 
    130                 135                 140                 


Leu Pro Leu Glu Trp Xaa Val Leu Gly Ser Ser Ser Leu Glu Val Ser 
145                 150                 155                 160 


Ser His Arg Glu Ser Leu Leu His Leu Ala Met Arg Trp Gly Leu Ala 
                165                 170                 175     


Lys Leu Ser Gln Phe Phe Leu Cys Leu Pro Gly Gly Val Gln Ala Leu 
            180                 185                 190         


Ala Leu Pro Asn Glu Glu Gly Ala Xaa Pro Leu Asp Leu Ala Leu Arg 
        195                 200                 205             


Glu Gly His Ser Lys Leu Val Glu Asp Val Xaa Asn Phe Gln Gly Arg 
    210                 215                 220                 


Trp Ser Pro Ser Phe Ser Arg Val Gln Leu Ser Glu Glu Ala Ser Leu 
225                 230                 235                 240 


His Tyr Ile His Ser Ser Glu Xaa Leu Xaa Leu Xaa Leu Asn His Xaa 
                245                 250                 255     


Ala Glu His Leu Leu Glu Ala Asp Ile Lys Leu Phe Arg Lys Tyr Phe 
            260                 265                 270         


Trp Asp Arg Ala Phe Leu Val Lys Ala Phe Glu Pro Glu Ala Arg Pro 
        275                 280                 285             


Glu Glu Arg Xaa Ala Met Pro Ser Ser Gly Ala Glu Xaa Glu Glu Glu 
    290                 295                 300                 


Ile Lys Asn Ser Val Ser Ser Arg Ser Ala Ala Glu Lys Glu Asp Ile 
305                 310                 315                 320 


Lys Arg Val Lys Ser Leu Val Val Gln His Asn Glu His Glu Asp Gln 
                325                 330                 335     


His Ser Leu Asp Leu Asp Arg Ser Phe Asp Ile Leu Lys Lys Ser Lys 
            340                 345                 350         


Pro Pro Ser Xaa Leu Leu Ala Ala Gly Arg Leu Ser Asp Met Leu Asn 
        355                 360                 365             


Gly Gly Asp Glu Val Tyr Ala Asn Cys Met Val Ile Asp Gln Val Gly 
    370                 375                 380                 


Asp Leu Asp Ile Ser Tyr Ile Asn Ile Glu Gly Ile Xaa Ala Xaa Xaa 
385                 390                 395                 400 


Ser Pro Glu Ser Arg Gly Cys Xaa Leu Trp Pro Gln Ser Ser Lys His 
                405                 410                 415     


Xaa Leu Pro Xaa Glu Xaa Ser Pro Ser Val Tyr Pro Leu Ser Glu Asn 
            420                 425                 430         


Val Glu Gly Xaa Ala His Xaa Glu Ala Gln Gln Ser Phe Met Ser Pro 
        435                 440                 445             


Ser Ser Ser Cys Ala Ser Asn Leu Asn Leu Ser Phe Gly Trp His Gly 
    450                 455                 460                 


Phe Glu Lys Glu Gln Ser His Leu Lys Lys Arg Ser Ser Ser Leu Asp 
465                 470                 475                 480 


Ala Leu Asp Ala Asp Ser Glu Gly Glu Gly His Ser Glu Pro Ser His 
                485                 490                 495     


Ile Cys Tyr Xaa Pro Gly Ser Gln Ser Ser Ser Arg Xaa Gly Ile Pro 
            500                 505                 510         


Ser Gly Asp Glu Leu Asp Ser Phe Glu Xaa Asn Xaa Glu Pro Asp Phe 
        515                 520                 525             


Asn Ile Ser Arg Ala Glu Ser Leu Pro Leu Ser Ser Asn Leu Gln Ser 
    530                 535                 540                 


Lys Glu Ser Leu Leu Ser Gly Val Arg Ser Arg Ser Tyr Ser Cys Ser 
545                 550                 555                 560 


Ser Pro Lys Ile Ser Leu Gly Lys Xaa Arg Leu Val Arg Glu Leu Xaa 
                565                 570                 575     


Val Cys Ser Ser Ser Glu Glu Gln Arg Ala Tyr Ser Leu Ser Glu Pro 
            580                 585                 590         


Pro Arg Glu Asn Arg Ile Gln Glu Glu Glu Trp Asp Lys Tyr Ile Ile 
        595                 600                 605             


Pro Ala Lys Ser Glu Ser Glu Lys Tyr Lys Val Ser Arg Xaa Phe Ser 
    610                 615                 620                 


Phe Leu Met Asn Arg Met Xaa Ser Pro Arg Asn Lys Ser Lys Xaa Lys 
625                 630                 635                 640 


Ser Lys Asp Ala Lys Asp Lys Glu Lys Leu Asn Arg His Gln Phe Ala 
                645                 650                 655     


Pro Gly Xaa Phe Ser Gly Val Leu Gln Cys Leu Val Cys Asp Lys Xaa 
            660                 665                 670         


Leu Leu Gly Lys Glu Ser Leu Gln Cys Ser Asn Cys Asn Ala Asn Val 
        675                 680                 685             


His Lys Gly Cys Lys Asp Ala Ala Pro Ala Cys Xaa Lys Lys Phe Gln 
    690                 695                 700                 


Glu Lys Tyr Asn Lys Asn Lys Pro Gln Xaa Ile Leu Gly Asn Ser Ser 
705                 710                 715                 720 


Phe Arg Asp Ile Pro Gln Pro Gly Leu Ser Leu His Pro Ser Ser Ser 
                725                 730                 735     


Val Pro Val Gly Leu Pro Xaa Gly Arg Arg Glu Xaa Val Gly Gln Val 
            740                 745                 750         


His Pro Leu Ser Arg Ser Val Pro Gly Xaa Xaa Leu Glu Ser Phe Arg 
        755                 760                 765             


Arg Ser Ala Xaa Ser Leu Glu Ser Glu Ser Asp His Asn Ser Cys Arg 
    770                 775                 780                 


Ser Arg Ser His Ser Asp Glu Leu Leu Gln Ser Met Gly Ser Ser Pro 
785                 790                 795                 800 


Ser Xaa Glu Ser Phe Ile Met Glu Asp Val Val Asp Ser Ser Leu Trp 
                805                 810                 815     


Ser Asp Leu Ser Ser Asp Ala Gln Glu Phe Glu Ala Glu Ser Trp Ser 
            820                 825                 830         


Leu Val Val Asp Pro Ser Phe Cys Asn Arg Gln Glu Lys Asp Val Ile 
        835                 840                 845             


Lys Arg Gln Asp Val Ile Phe Glu Leu Met Gln Xaa Glu Met His His 
    850                 855                 860                 


Ile Gln Xaa Leu Phe Ile Met Ser Glu Ile Phe Arg Lys Gly Met Lys 
865                 870                 875                 880 


Glu Glu Leu Gln Leu Asp His Ser Xaa Val Asp Lys Ile Phe Pro Cys 
                885                 890                 895     


Leu Asp Glu Leu Leu Glu Ile His Arg His Phe Phe Tyr Ser Met Lys 
            900                 905                 910         


Glu Arg Arg Gln Glu Ser Cys Ala Gly Ser Asp Arg Asn Phe Val Ile 
        915                 920                 925             


Asp Arg Ile Gly Asp Ile Leu Val Gln Gln Phe Ser Glu Glu Asn Ala 
    930                 935                 940                 


Ser Lys Met Lys Lys Ile Tyr Gly Glu Phe Cys Cys His His Lys Glu 
945                 950                 955                 960 


Ala Val Asn Leu Phe Lys Glu Leu Gln Gln Asn Lys Lys Phe Gln Asn 
                965                 970                 975     


Phe Ile Lys Leu Arg Asn Ser Asn Leu Leu Ala Arg Arg Arg Gly Ile 
            980                 985                 990         


Pro Glu Cys Ile Leu Leu Val Xaa  Gln Arg Ile Xaa Lys  Tyr Pro Val 
        995                 1000                 1005             


Leu Val  Glu Arg Ile Leu Gln  Tyr Xaa Lys Glu Arg  Xaa Glu Glu 
    1010                 1015                 1020             


His Lys  Asp Leu Arg Lys Ala  Leu Cys Leu Ile Lys  Asp Met Ile 
    1025                 1030                 1035             


Ala Xaa  Val Asp Leu Lys Val  Asn Glu Tyr Glu Lys  Asn Gln Lys 
    1040                 1045                 1050             


Trp Leu  Glu Ile Leu Asn Lys  Ile Glu Asn Lys Xaa  Tyr Xaa Lys 
    1055                 1060                 1065             


Leu Lys  Asn Gly His Val Phe  Arg Lys Gln Ala Leu  Met Ser Glu 
    1070                 1075                 1080             


Glu Arg  Xaa Leu Leu Tyr Asp  Gly Leu Val Tyr Trp  Lys Xaa Ala 
    1085                 1090                 1095             


Xaa Gly  Arg Phe Lys Asp Ile  Leu Ala Leu Leu Leu  Xaa Asp Val 
    1100                 1105                 1110             


Leu Leu  Phe Leu Gln Glu Lys  Asp Gln Lys Tyr Ile  Phe Ala Ala 
    1115                 1120                 1125             


Val Asp  Gln Lys Pro Ser Val  Ile Ser Leu Gln Lys  Leu Ile Ala 
    1130                 1135                 1140             


Arg Glu  Val Ala Asn Glu Glu  Arg Gly Met Phe Leu  Ile Ser Ala 
    1145                 1150                 1155             


Ser Ser  Ala Gly Pro Glu Met  Tyr Glu Ile His Xaa  Asn Ser Lys 
    1160                 1165                 1170             


Glu Glu  Arg Asn Asn Trp Met  Arg Arg Ile Gln Gln  Ala Val Glu 
    1175                 1180                 1185             


Ser Cys  Pro Glu Glu Lys Gly  Gly Arg Xaa Ser Glu  Ser Asp Glu 
    1190                 1195                 1200             


Asp Lys  Arg Lys Ala Glu Ala  Arg Val Ala Lys Ile  Gln Gln Cys 
    1205                 1210                 1215             


Gln Glu  Ile Leu Xaa Asn Gln  Asp Gln Gln Ile Cys  Ala Tyr Leu 
    1220                 1225                 1230             


Glu Glu  Lys Leu His Ile Tyr  Ala Glu Leu Gly Glu  Leu Ser Gly 
    1235                 1240                 1245             


Phe Glu  Asp Val His Leu Glu  Pro His Leu Leu Ile  Lys Pro Asp 
    1250                 1255                 1260             


Pro Gly  Glu Pro Pro Gln Ala  Ala Ser Leu Leu Ala  Ala Ala Leu 
    1265                 1270                 1275             


Lys Glu  Ala Glu Ser Leu Gln  Val Ala Val Lys Ala  Ser Gln Met 
    1280                 1285                 1290             


Gly Ala  Val Ser Gln Ser Cys  Glu Asp Ser Cys Gly  Asp Ser Val 
    1295                 1300                 1305             


Leu Ala  Asp Xaa Leu Ser Ser  His Asp Val Pro Gly  Ser Pro Xaa 
    1310                 1315                 1320             


Ala Ser  Leu Val Xaa Gly Gly  Arg Glu Gly Arg Gly  Cys Ser Asp 
    1325                 1330                 1335             


Val Asp  Pro Gly Ile Gln Gly  Val Val Xaa Asp Leu  Ala Val Ser 
    1340                 1345                 1350             


Asp Ala  Gly Glu Lys Val Glu  Cys Arg Asn Phe Pro  Gly Ser Ser 
    1355                 1360                 1365             


Gln Ser  Glu Ile Ile Gln Ala  Ile Gln Asn Leu Xaa  Arg Leu Leu 
    1370                 1375                 1380             


Tyr Ser  Leu Gln Ala Ala Leu  Xaa Ile Gln Asp Ser  His Ile Glu 
    1385                 1390                 1395             


Ile His  Arg Leu Val Leu Gln  Gln Gln Glu Gly Leu  Ser Leu Gly 
    1400                 1405                 1410             


His Ser  Ile Leu Arg Gly Gly  Pro Leu Gln Asp Gln  Lys Ser Arg 
    1415                 1420                 1425             


Asp Ala  Asp Arg Gln His Glu  Glu Leu Ala Asn Val  His Gln Leu 
    1430                 1435                 1440             


Gln His  Gln Leu Gln Gln Glu  Gln Arg Arg Trp Leu  Arg Arg Cys 
    1445                 1450                 1455             


Glu Gln  Gln Gln Arg Ala Gln  Ala Xaa Arg Glu Ser  Trp Leu Gln 
    1460                 1465                 1470             


Glu Arg  Glu Arg Glu Cys Gln  Ser Gln Glu Glu Leu  Leu Leu Arg 
    1475                 1480                 1485             


Ser Arg  Gly Glu Leu Asp Leu  Gln Leu Gln Glu Tyr  Gln His Ser 
    1490                 1495                 1500             


Leu Glu  Arg Leu Arg Glu Gly  Gln Arg Leu Val Glu  Arg Glu Gln 
    1505                 1510                 1515             


Ala Arg  Met Arg Ala Gln Gln  Ser Leu Leu Gly His  Trp Lys His 
    1520                 1525                 1530             


Gly Arg  Gln Arg Ser Leu Pro  Ala Val Leu Leu Pro  Gly Gly Pro 
    1535                 1540                 1545             


Glu Val  Met Glu Leu Asn Arg  Ser Glu Ser Leu Cys  His Glu Asn 
    1550                 1555                 1560             


Ser Phe  Phe Ile Asn Glu Ala  Leu Val Gln Met Ser  Phe Asn Xaa 
    1565                 1570                 1575             


Phe Asn  Lys Leu Asn Pro Ser  Val Ile His Gln Asp  Ala Xaa Tyr 
    1580                 1585                 1590             


Pro Xaa  Xaa Gln Ser His Ser  Asp Leu Val Arg Xaa  Ser Glu His 
    1595                 1600                 1605             


Gln Val  Asp Leu Lys Val Asp  Pro Ser Gln Pro Ser  Asn Val Ser 
    1610                 1615                 1620             


His Lys  Leu Trp Xaa Ala Ala  Gly Ser Gly His Gln  Ile Leu Pro 
    1625                 1630                 1635             


Phe His  Glu Ser Ser Lys Asp  Ser Cys Lys Asn Asp  Leu Asp Xaa 
    1640                 1645                 1650             


Ser His  Xaa Glu Ser Pro Xaa  Pro His Asp Ser Asn  Ser His Arg 
    1655                 1660                 1665             


Pro Gln  Leu Gln Ala Phe Ile  Xaa Glu Ala Lys Leu  Asn Leu Pro 
    1670                 1675                 1680             


Xaa Arg  Xaa Met Xaa Arg Gln  Asp Gly Glu Xaa Gly  Asp Gly Ala 
    1685                 1690                 1695             


Lys Glu  Asn Ile Val Tyr Leu  
    1700                 1705 


<210> 3009
<211> 1731
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1017)..(1017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1323)..(1323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1328)..(1328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1380)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1391)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1467)..(1467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1578)..(1578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1592)..(1592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1595)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1605)..(1605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1628)..(1628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1654)..(1654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1659)..(1659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1661)..(1661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1668)..(1668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1670)..(1671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1673)..(1673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1679)..(1679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1682)..(1682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1686)..(1686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1702)..(1702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1710)..(1710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1712)..(1712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1714)..(1714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1720)..(1720)
<223> Selenocysteine

<400> 3009
Met Glu Leu Ser Cys Ser Glu Ala Pro Leu Tyr Gly Gln Met Met Ile 
1               5                   10                  15      


Tyr Ala Lys Phe Asp Lys Asn Val Tyr Leu Pro Glu Asp Ala Glu Phe 
            20                  25                  30          


Tyr Phe Xaa Tyr Asp Gly Ser His Gln Arg His Val Met Ile Ala Glu 
        35                  40                  45              


Arg Ile Glu Asp Asn Val Leu Gln Ser Ser Val Pro Gly His Gly Leu 
    50                  55                  60                  


Gln Glu Xaa Val Xaa Val Ser Val Cys Leu Cys Ser Glu Gly Tyr Ser 
65                  70                  75                  80  


Pro Val Xaa Met Gly Ser Gly Ser Val Xaa Tyr Val Asp Asn Met Ala 
                85                  90                  95      


Cys Arg Leu Ala Arg Leu Leu Val Xaa Gln Ala Asn Arg Leu Xaa Ala 
            100                 105                 110         


Cys Ser His Gln Xaa Leu Leu Xaa Pro Phe Ala Leu Xaa Ala Gly Ala 
        115                 120                 125             


Leu Pro Ala Leu Asp Glu Glu Leu Val Leu Ala Leu Xaa His Leu Glu 
    130                 135                 140                 


Leu Pro Leu Glu Trp Xaa Val Leu Gly Ser Ser Ser Leu Glu Val Ser 
145                 150                 155                 160 


Ser His Arg Glu Ser Leu Leu His Leu Ala Met Arg Trp Gly Leu Ala 
                165                 170                 175     


Lys Leu Ser Gln Phe Phe Leu Cys Leu Pro Gly Gly Val Gln Ala Leu 
            180                 185                 190         


Ala Leu Pro Asn Glu Glu Gly Ala Xaa Pro Leu Asp Leu Ala Leu Arg 
        195                 200                 205             


Glu Gly His Ser Lys Leu Val Glu Asp Val Xaa Asn Phe Gln Gly Arg 
    210                 215                 220                 


Trp Ser Pro Ser Phe Ser Arg Val Gln Leu Ser Glu Glu Ala Ser Leu 
225                 230                 235                 240 


His Tyr Ile His Ser Ser Glu Xaa Leu Xaa Leu Xaa Leu Asn His Xaa 
                245                 250                 255     


Ala Glu His Leu Leu Glu Ala Asp Ile Lys Leu Phe Arg Lys Tyr Phe 
            260                 265                 270         


Trp Asp Arg Ala Phe Leu Val Lys Ala Phe Glu Pro Glu Ala Arg Pro 
        275                 280                 285             


Glu Glu Arg Xaa Ala Met Pro Ser Ser Gly Ala Glu Xaa Glu Glu Glu 
    290                 295                 300                 


Ile Lys Asn Ser Val Ser Ser Arg Ser Ala Ala Glu Lys Glu Asp Ile 
305                 310                 315                 320 


Lys Arg Val Lys Ser Leu Val Val Gln His Asn Glu His Glu Asp Gln 
                325                 330                 335     


His Ser Leu Asp Leu Asp Arg Ser Phe Asp Ile Leu Lys Lys Ser Lys 
            340                 345                 350         


Pro Pro Ser Xaa Leu Leu Ala Ala Gly Arg Leu Ser Asp Met Leu Asn 
        355                 360                 365             


Gly Gly Asp Glu Val Tyr Ala Asn Cys Met Val Ile Asp Gln Val Gly 
    370                 375                 380                 


Asp Leu Asp Ile Ser Tyr Ile Asn Ile Glu Gly Ile Xaa Ala Xaa Xaa 
385                 390                 395                 400 


Ser Pro Glu Ser Arg Gly Cys Xaa Leu Trp Pro Gln Ser Ser Lys His 
                405                 410                 415     


Xaa Leu Pro Xaa Glu Xaa Ser Pro Ser Val Tyr Pro Leu Ser Glu Asn 
            420                 425                 430         


Val Glu Gly Xaa Ala His Xaa Glu Ala Gln Gln Ser Phe Met Ser Pro 
        435                 440                 445             


Ser Ser Ser Cys Ala Ser Asn Leu Asn Leu Ser Phe Gly Trp His Gly 
    450                 455                 460                 


Phe Glu Lys Glu Gln Ser His Leu Lys Lys Arg Ser Ser Ser Leu Asp 
465                 470                 475                 480 


Ala Leu Asp Ala Asp Ser Glu Gly Glu Gly His Ser Glu Pro Ser His 
                485                 490                 495     


Ile Cys Tyr Xaa Pro Gly Ser Gln Ser Ser Ser Arg Xaa Gly Ile Pro 
            500                 505                 510         


Ser Gly Asp Glu Leu Asp Ser Phe Glu Xaa Asn Xaa Glu Pro Asp Phe 
        515                 520                 525             


Asn Ile Ser Arg Ala Glu Ser Leu Pro Leu Ser Ser Asn Leu Gln Ser 
    530                 535                 540                 


Lys Glu Ser Leu Leu Ser Gly Val Arg Ser Arg Ser Tyr Ser Cys Ser 
545                 550                 555                 560 


Ser Pro Lys Ile Ser Leu Gly Lys Xaa Arg Leu Val Arg Glu Leu Xaa 
                565                 570                 575     


Val Cys Ser Ser Ser Glu Glu Gln Arg Ala Tyr Ser Leu Ser Glu Pro 
            580                 585                 590         


Pro Arg Glu Asn Arg Ile Gln Glu Glu Glu Trp Asp Lys Tyr Ile Ile 
        595                 600                 605             


Pro Ala Lys Ser Glu Ser Glu Lys Tyr Lys Val Ser Arg Xaa Phe Ser 
    610                 615                 620                 


Phe Leu Met Asn Arg Met Xaa Ser Pro Arg Asn Lys Ser Lys Xaa Lys 
625                 630                 635                 640 


Ser Lys Asp Ala Lys Asp Lys Glu Lys Leu Asn Arg His Gln Phe Ala 
                645                 650                 655     


Pro Gly Xaa Phe Ser Gly Val Leu Gln Cys Leu Val Cys Asp Lys Xaa 
            660                 665                 670         


Leu Leu Gly Lys Glu Ser Leu Gln Cys Ser Asn Cys Asn Ala Asn Val 
        675                 680                 685             


His Lys Gly Cys Lys Asp Ala Ala Pro Ala Cys Xaa Lys Lys Phe Gln 
    690                 695                 700                 


Glu Lys Tyr Asn Lys Asn Lys Pro Gln Xaa Ile Leu Gly Asn Ser Ser 
705                 710                 715                 720 


Phe Arg Asp Ile Pro Gln Pro Gly Leu Ser Leu His Pro Ser Ser Ser 
                725                 730                 735     


Val Pro Val Gly Leu Pro Xaa Gly Arg Arg Glu Xaa Val Gly Gln Val 
            740                 745                 750         


His Pro Leu Ser Arg Ser Val Pro Gly Xaa Xaa Leu Glu Ser Phe Arg 
        755                 760                 765             


Arg Ser Ala Xaa Ser Leu Glu Ser Glu Ser Asp His Asn Ser Cys Arg 
    770                 775                 780                 


Ser Arg Ser His Ser Asp Glu Leu Leu Gln Ser Met Gly Ser Ser Pro 
785                 790                 795                 800 


Ser Xaa Glu Ser Phe Ile Met Glu Asp Val Val Asp Ser Ser Leu Trp 
                805                 810                 815     


Ser Asp Leu Ser Ser Asp Ala Gln Glu Phe Glu Ala Glu Ser Trp Ser 
            820                 825                 830         


Leu Val Val Asp Pro Ser Phe Cys Asn Arg Gln Glu Lys Asp Val Ile 
        835                 840                 845             


Lys Arg Gln Asp Val Ile Phe Glu Leu Met Gln Xaa Glu Met His His 
    850                 855                 860                 


Ile Gln Xaa Leu Phe Ile Met Ser Glu Ile Phe Arg Lys Gly Met Lys 
865                 870                 875                 880 


Glu Glu Leu Gln Leu Asp His Ser Xaa Val Asp Lys Ile Phe Pro Cys 
                885                 890                 895     


Leu Asp Glu Leu Leu Glu Ile His Arg His Phe Phe Tyr Ser Met Lys 
            900                 905                 910         


Glu Arg Arg Gln Glu Ser Cys Ala Gly Ser Asp Arg Asn Phe Val Ile 
        915                 920                 925             


Asp Arg Ile Gly Asp Ile Leu Val Gln Gln Phe Ser Glu Glu Asn Ala 
    930                 935                 940                 


Ser Lys Met Lys Lys Ile Tyr Gly Glu Phe Cys Cys His His Lys Glu 
945                 950                 955                 960 


Ala Val Asn Leu Phe Lys Glu Leu Gln Gln Asn Lys Lys Phe Gln Asn 
                965                 970                 975     


Phe Ile Lys Leu Arg Asn Ser Asn Leu Leu Ala Arg Arg Arg Gly Ile 
            980                 985                 990         


Pro Glu Cys Ile Leu Leu Val Xaa  Gln Arg Ile Xaa Lys  Tyr Pro Val 
        995                 1000                 1005             


Leu Val  Glu Arg Ile Leu Gln  Tyr Xaa Lys Glu Arg  Xaa Glu Glu 
    1010                 1015                 1020             


His Lys  Asp Leu Arg Lys Ala  Leu Cys Leu Ile Lys  Asp Met Ile 
    1025                 1030                 1035             


Ala Xaa  Val Asp Leu Lys Val  Asn Glu Tyr Glu Lys  Asn Gln Lys 
    1040                 1045                 1050             


Trp Leu  Glu Ile Leu Asn Lys  Ile Glu Asn Lys Xaa  Tyr Xaa Lys 
    1055                 1060                 1065             


Leu Lys  Asn Gly His Val Phe  Arg Lys Gln Ala Leu  Met Ser Glu 
    1070                 1075                 1080             


Glu Arg  Xaa Leu Leu Tyr Asp  Gly Leu Val Tyr Trp  Lys Xaa Ala 
    1085                 1090                 1095             


Xaa Gly  Arg Phe Lys Asp Ile  Leu Ala Leu Leu Leu  Xaa Asp Val 
    1100                 1105                 1110             


Leu Leu  Phe Leu Gln Glu Lys  Asp Gln Lys Tyr Ile  Phe Ala Ala 
    1115                 1120                 1125             


Val Asp  Gln Lys Pro Ser Val  Ile Ser Leu Gln Lys  Leu Ile Ala 
    1130                 1135                 1140             


Arg Glu  Val Ala Asn Glu Glu  Arg Gly Met Phe Leu  Ile Ser Ala 
    1145                 1150                 1155             


Ser Ser  Ala Gly Pro Glu Met  Tyr Glu Ile His Xaa  Asn Ser Lys 
    1160                 1165                 1170             


Glu Glu  Arg Asn Asn Trp Met  Arg Arg Ile Gln Gln  Ala Val Glu 
    1175                 1180                 1185             


Ser Cys  Pro Glu Glu Lys Gly  Gly Arg Xaa Ser Glu  Ser Asp Glu 
    1190                 1195                 1200             


Asp Lys  Arg Lys Ala Glu Ala  Arg Val Ala Lys Ile  Gln Gln Cys 
    1205                 1210                 1215             


Gln Glu  Ile Leu Xaa Asn Gln  Asp Gln Gln Ile Cys  Ala Tyr Leu 
    1220                 1225                 1230             


Glu Glu  Lys Leu His Ile Tyr  Ala Glu Leu Gly Glu  Leu Ser Gly 
    1235                 1240                 1245             


Phe Glu  Asp Val His Leu Glu  Pro His Leu Leu Ile  Lys Pro Asp 
    1250                 1255                 1260             


Pro Gly  Glu Pro Pro Gln Ala  Ala Ser Leu Leu Ala  Ala Ala Leu 
    1265                 1270                 1275             


Lys Glu  Ala Glu Ser Leu Gln  Val Ala Val Lys Ala  Ser Gln Met 
    1280                 1285                 1290             


Gly Ala  Val Ser Gln Ser Cys  Glu Asp Ser Cys Gly  Asp Ser Val 
    1295                 1300                 1305             


Leu Ala  Asp Xaa Leu Ser Ser  His Asp Val Pro Gly  Ser Pro Xaa 
    1310                 1315                 1320             


Ala Ser  Leu Val Xaa Gly Gly  Arg Glu Gly Arg Gly  Cys Ser Asp 
    1325                 1330                 1335             


Val Asp  Pro Gly Ile Gln Gly  Val Val Xaa Asp Leu  Ala Val Ser 
    1340                 1345                 1350             


Asp Ala  Gly Glu Lys Val Glu  Cys Arg Asn Phe Pro  Gly Ser Ser 
    1355                 1360                 1365             


Gln Ser  Glu Ile Ile Gln Ala  Ile Gln Asn Leu Xaa  Arg Leu Leu 
    1370                 1375                 1380             


Tyr Ser  Leu Gln Ala Ala Leu  Xaa Ile Gln Asp Ser  His Ile Glu 
    1385                 1390                 1395             


Ile His  Arg Leu Val Leu Gln  Gln Gln Glu Gly Leu  Ser Leu Gly 
    1400                 1405                 1410             


His Ser  Ile Leu Arg Gly Gly  Pro Leu Gln Asp Gln  Lys Ser Arg 
    1415                 1420                 1425             


Asp Ala  Asp Arg Gln His Glu  Glu Leu Ala Asn Val  His Gln Leu 
    1430                 1435                 1440             


Gln His  Gln Leu Gln Gln Glu  Gln Arg Arg Trp Leu  Arg Arg Cys 
    1445                 1450                 1455             


Glu Gln  Gln Gln Arg Ala Gln  Ala Xaa Arg Glu Ser  Trp Leu Gln 
    1460                 1465                 1470             


Glu Arg  Glu Arg Glu Cys Gln  Ser Gln Glu Glu Leu  Leu Leu Arg 
    1475                 1480                 1485             


Ser Arg  Gly Glu Leu Asp Leu  Gln Leu Gln Glu Tyr  Gln His Ser 
    1490                 1495                 1500             


Leu Glu  Arg Leu Arg Glu Gly  Gln Arg Leu Val Glu  Arg Glu Gln 
    1505                 1510                 1515             


Ala Arg  Met Arg Ala Gln Gln  Ser Leu Leu Gly His  Trp Lys His 
    1520                 1525                 1530             


Gly Arg  Gln Arg Ser Leu Pro  Ala Val Leu Leu Pro  Gly Gly Pro 
    1535                 1540                 1545             


Glu Val  Met Glu Leu Asn Arg  Ser Glu Ser Leu Cys  His Glu Asn 
    1550                 1555                 1560             


Ser Phe  Phe Ile Asn Glu Ala  Leu Val Gln Met Ser  Phe Asn Xaa 
    1565                 1570                 1575             


Phe Asn  Lys Leu Asn Pro Ser  Val Ile His Gln Asp  Ala Xaa Tyr 
    1580                 1585                 1590             


Pro Xaa  Xaa Gln Ser His Ser  Asp Leu Val Arg Xaa  Ser Glu His 
    1595                 1600                 1605             


Gln Val  Asp Leu Lys Val Asp  Pro Ser Gln Pro Ser  Asn Val Ser 
    1610                 1615                 1620             


His Lys  Leu Trp Xaa Ala Ala  Gly Ser Gly His Gln  Ile Leu Pro 
    1625                 1630                 1635             


Phe His  Glu Ser Ser Lys Asp  Ser Cys Lys Asn Gly  Ser Ser Met 
    1640                 1645                 1650             


Xaa Lys  Cys Ser Cys Xaa Leu  Xaa Ser Pro Pro Gly  Leu Trp Xaa 
    1655                 1660                 1665             


Gly Xaa  Xaa Ser Xaa Leu Lys  Asp Leu Asp Xaa Ser  His Xaa Glu 
    1670                 1675                 1680             


Ser Pro  Xaa Pro His Asp Ser  Asn Ser His Arg Pro  Gln Leu Gln 
    1685                 1690                 1695             


Ala Phe  Ile Xaa Glu Ala Lys  Leu Asn Leu Pro Xaa  Arg Xaa Met 
    1700                 1705                 1710             


Xaa Arg  Gln Asp Gly Glu Xaa  Gly Asp Gly Ala Lys  Glu Asn Ile 
    1715                 1720                 1725             


Val Tyr  Leu 
    1730     


<210> 3010
<211> 651
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<400> 3010
Met Ile Ala Xaa Val Asp Leu Lys Val Asn Glu Tyr Glu Lys Asn Gln 
1               5                   10                  15      


Lys Trp Leu Glu Ile Leu Asn Lys Ile Glu Asn Lys Xaa Tyr Xaa Lys 
            20                  25                  30          


Leu Lys Asn Gly His Val Phe Arg Lys Gln Ala Leu Met Ser Glu Glu 
        35                  40                  45              


Arg Xaa Leu Leu Tyr Asp Gly Leu Val Tyr Trp Lys Xaa Ala Xaa Gly 
    50                  55                  60                  


Arg Phe Lys Asp Ile Leu Ala Leu Leu Leu Xaa Asp Val Leu Leu Phe 
65                  70                  75                  80  


Leu Gln Glu Lys Asp Gln Lys Tyr Ile Phe Ala Ala Val Asp Gln Lys 
                85                  90                  95      


Pro Ser Val Ile Ser Leu Gln Lys Leu Ile Ala Arg Glu Val Ala Asn 
            100                 105                 110         


Glu Glu Arg Gly Met Phe Leu Ile Ser Ala Ser Ser Ala Gly Pro Glu 
        115                 120                 125             


Met Tyr Glu Ile His Xaa Asn Ser Lys Glu Glu Arg Asn Asn Trp Met 
    130                 135                 140                 


Arg Arg Ile Gln Gln Ala Val Glu Ser Cys Pro Glu Glu Lys Gly Gly 
145                 150                 155                 160 


Arg Xaa Ser Glu Ser Asp Glu Asp Lys Arg Lys Ala Glu Ala Arg Val 
                165                 170                 175     


Ala Lys Ile Gln Gln Cys Gln Glu Ile Leu Xaa Asn Gln Asp Gln Gln 
            180                 185                 190         


Ile Cys Ala Tyr Leu Glu Glu Lys Leu His Ile Tyr Ala Glu Leu Gly 
        195                 200                 205             


Glu Leu Ser Gly Phe Glu Asp Val His Leu Glu Pro His Leu Leu Ile 
    210                 215                 220                 


Lys Pro Asp Pro Gly Glu Pro Pro Gln Ala Ala Ser Leu Leu Ala Ala 
225                 230                 235                 240 


Ala Leu Lys Glu Ala Leu Val Xaa Gly Gly Arg Glu Gly Arg Gly Cys 
                245                 250                 255     


Ser Asp Val Asp Pro Gly Ile Gln Gly Val Val Xaa Asp Leu Ala Val 
            260                 265                 270         


Ser Asp Ala Gly Glu Lys Val Glu Cys Arg Asn Phe Pro Gly Ser Ser 
        275                 280                 285             


Gln Ser Glu Ile Ile Gln Ala Ile Gln Asn Leu Xaa Arg Leu Leu Tyr 
    290                 295                 300                 


Ser Leu Gln Ala Ala Leu Xaa Ile Gln Asp Ser His Ile Glu Ile His 
305                 310                 315                 320 


Arg Leu Val Leu Gln Gln Gln Glu Gly Leu Ser Leu Gly His Ser Ile 
                325                 330                 335     


Leu Arg Gly Gly Pro Leu Gln Asp Gln Lys Ser Arg Asp Ala Asp Arg 
            340                 345                 350         


Gln His Glu Glu Leu Ala Asn Val His Gln Leu Gln His Gln Leu Gln 
        355                 360                 365             


Gln Glu Gln Arg Arg Trp Leu Arg Arg Cys Glu Gln Gln Gln Arg Ala 
    370                 375                 380                 


Gln Ala Xaa Arg Glu Ser Trp Leu Gln Glu Arg Glu Arg Glu Cys Gln 
385                 390                 395                 400 


Ser Gln Glu Glu Leu Leu Leu Arg Ser Arg Gly Glu Leu Asp Leu Gln 
                405                 410                 415     


Leu Gln Glu Tyr Gln His Ser Leu Glu Arg Leu Arg Glu Gly Gln Arg 
            420                 425                 430         


Leu Val Glu Arg Glu Gln Ala Arg Met Arg Ala Gln Gln Ser Leu Leu 
        435                 440                 445             


Gly His Trp Lys His Gly Arg Gln Arg Ser Leu Pro Ala Val Leu Leu 
    450                 455                 460                 


Pro Gly Gly Pro Glu Val Met Glu Leu Asn Arg Ser Glu Ser Leu Cys 
465                 470                 475                 480 


His Glu Asn Ser Phe Phe Ile Asn Glu Ala Leu Val Gln Met Ser Phe 
                485                 490                 495     


Asn Xaa Phe Asn Lys Leu Asn Pro Ser Val Ile His Gln Asp Ala Xaa 
            500                 505                 510         


Tyr Pro Xaa Xaa Gln Ser His Ser Asp Leu Val Arg Xaa Ser Glu His 
        515                 520                 525             


Gln Val Asp Leu Lys Val Asp Pro Ser Gln Pro Ser Asn Val Ser His 
    530                 535                 540                 


Lys Leu Trp Xaa Ala Ala Gly Ser Gly His Gln Ile Leu Pro Phe His 
545                 550                 555                 560 


Glu Ser Ser Lys Asp Ser Cys Lys Asn Gly Ser Ser Met Xaa Lys Cys 
                565                 570                 575     


Ser Cys Xaa Leu Xaa Ser Pro Pro Gly Leu Trp Xaa Gly Xaa Xaa Ser 
            580                 585                 590         


Xaa Leu Lys Asp Leu Asp Xaa Ser His Xaa Glu Ser Pro Xaa Pro His 
        595                 600                 605             


Asp Ser Asn Ser His Arg Pro Gln Leu Gln Ala Phe Ile Xaa Glu Ala 
    610                 615                 620                 


Lys Leu Asn Leu Pro Xaa Arg Xaa Met Xaa Arg Gln Asp Gly Glu Xaa 
625                 630                 635                 640 


Gly Asp Gly Ala Lys Glu Asn Ile Val Tyr Leu 
                645                 650     


<210> 3011
<211> 50
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<400> 3011
Met Asp Ser Ser Xaa Ala Met Asn Gln Cys Ser Cys Arg Gly Met Glu 
1               5                   10                  15      


Glu Asn Lys Glu Arg Ala Val Gly Gly Val Ser Gly Xaa Ser Ala Ile 
            20                  25                  30          


Asn Gly Arg Asn Asn Trp Phe Phe Arg Leu Leu Arg Lys Ser Asp Leu 
        35                  40                  45              


Cys Gly 
    50  


<210> 3012
<211> 100
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 3012
Met Asp Ser Ser Xaa Ala Met Asn Gln Cys Ser Cys Arg Gly Met Glu 
1               5                   10                  15      


Glu Asn Lys Glu Arg Pro Lys Arg Gln Arg Gln Asn Asn Phe Pro Met 
            20                  25                  30          


Phe Pro Ser Pro Lys Ala Trp Asn Phe Arg Gly Arg Lys Arg Lys Gln 
        35                  40                  45              


Ser Xaa Gln Asp Glu Asp Ala Val Ser Leu Cys Ser Leu Asp Ile Ser 
    50                  55                  60                  


Glu Pro Ser Asn Lys Arg Val Lys Pro Leu Ser Arg Val Xaa Ser Leu 
65                  70                  75                  80  


Ala Asn Leu Ile Pro Pro Val Lys Ala Xaa Pro Leu Lys Arg Phe Ser 
                85                  90                  95      


Gln Xaa Leu Gln 
            100 


<210> 3013
<211> 558
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<400> 3013
Met Asp Ser Ser Xaa Ala Met Asn Gln Cys Ser Cys Arg Gly Met Glu 
1               5                   10                  15      


Glu Asn Lys Glu Arg Pro Lys Arg Gln Arg Gln Asn Asn Phe Pro Met 
            20                  25                  30          


Phe Pro Ser Pro Lys Ala Trp Asn Phe Arg Gly Arg Lys Arg Lys Gln 
        35                  40                  45              


Ser Xaa Gln Asp Glu Asp Ala Val Ser Leu Cys Ser Leu Asp Ile Ser 
    50                  55                  60                  


Glu Pro Ser Asn Lys Arg Val Lys Pro Leu Ser Arg Val Xaa Ser Leu 
65                  70                  75                  80  


Ala Asn Leu Ile Pro Pro Val Lys Ala Xaa Pro Leu Lys Arg Phe Ser 
                85                  90                  95      


Gln Xaa Leu Gln Arg Ser Ile Ser Phe Arg Ser Glu Ser Arg Pro Asp 
            100                 105                 110         


Ile Leu Ala Pro Arg Pro Trp Ser Arg Asn Ala Ala Pro Ser Ser Xaa 
        115                 120                 125             


Lys Arg Arg Asp Ser Lys Leu Trp Ser Glu Xaa Phe Asp Val Cys Val 
    130                 135                 140                 


Asn Gln Met Leu Xaa Ser Lys Glu Ile Lys Arg Gln Glu Ala Ile Phe 
145                 150                 155                 160 


Glu Leu Ser Gln Gly Glu Glu Asp Leu Ile Glu Asp Leu Lys Leu Ala 
                165                 170                 175     


Lys Lys Ala Tyr His Asp Pro Met Leu Lys Leu Ser Ile Met Xaa Glu 
            180                 185                 190         


Gln Glu Leu Asn Gln Ile Phe Gly Xaa Leu Asp Ser Leu Ile Pro Leu 
        195                 200                 205             


His Glu Glu Leu Leu Ser Gln Leu Arg Asp Val Arg Lys Pro Asp Gly 
    210                 215                 220                 


Ser Xaa Glu His Val Gly Pro Ile Leu Val Gly Trp Leu Pro Cys Leu 
225                 230                 235                 240 


Ser Ser Tyr Asp Ser Tyr Cys Ser Asn Gln Val Ala Ala Lys Ala Leu 
                245                 250                 255     


Leu Asp His Lys Lys Gln Asp His Arg Val Gln Asp Phe Leu Gln Arg 
            260                 265                 270         


Cys Leu Glu Ser Pro Phe Ser Arg Lys Leu Asp Leu Trp Asn Phe Leu 
        275                 280                 285             


Asp Ile Pro Arg Ser Arg Leu Val Lys Tyr Pro Leu Leu Leu Arg Glu 
    290                 295                 300                 


Ile Leu Arg His Xaa Pro Asn Asp Asn Pro Asp Gln Gln His Leu Glu 
305                 310                 315                 320 


Glu Ala Ile Asn Ile Ile Gln Gly Ile Val Ala Glu Ile Asn Xaa Lys 
                325                 330                 335     


Xaa Gly Glu Ser Glu Cys Arg Tyr Tyr Lys Glu Arg Leu Leu Tyr Leu 
            340                 345                 350         


Glu Glu Gly Gln Lys Asp Ser Leu Ile Asp Ser Ser Arg Val Leu Cys 
        355                 360                 365             


Cys His Gly Glu Leu Lys Asn Asn Arg Gly Val Lys Leu His Val Phe 
    370                 375                 380                 


Leu Phe Gln Glu Val Leu Val Ile Xaa Arg Ala Val Xaa His Asn Glu 
385                 390                 395                 400 


Gln Leu Cys Tyr Gln Leu Tyr Arg Gln Pro Ile Pro Val Lys Asp Leu 
                405                 410                 415     


Leu Leu Glu Asp Leu Gln Asp Gly Glu Val Arg Leu Gly Gly Ser Leu 
            420                 425                 430         


Arg Gly Ala Phe Ser Asn Asn Glu Arg Ile Lys Asn Phe Phe Arg Val 
        435                 440                 445             


Ser Phe Lys Asn Gly Ser Gln Ser Gln Xaa His Ser Leu Gln Ala Asn 
    450                 455                 460                 


Asp Xaa Phe Asn Lys Gln Gln Trp Leu Asn Cys Ile Arg Gln Ala Lys 
465                 470                 475                 480 


Glu Xaa Val Leu Cys Ala Ala Gly Gln Ala Gly Val Leu Asp Ser Glu 
                485                 490                 495     


Gly Ser Phe Leu Asn Pro Xaa Xaa Gly Ser Arg Glu Leu Gln Gly Glu 
            500                 505                 510         


Xaa Lys Leu Glu Gln Met Asp Gln Ser Asp Ser Glu Ser Asp Cys Ser 
        515                 520                 525             


Met Asp Xaa Ser Glu Val Ser Leu Asp Cys Glu Arg Met Glu Gln Xaa 
    530                 535                 540                 


Asp Ser Ser Cys Gly Asn Ser Arg His Gly Glu Ser Asn Val 
545                 550                 555             


<210> 3014
<211> 70
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<400> 3014
Met Phe Asp Arg Asn Ile Cys Pro Val Ile Leu His Val Lys Arg Xaa 
1               5                   10                  15      


Asn Ser Val Leu Ala Leu Arg Leu Val His Ser Leu Asn Gly Ser Gly 
            20                  25                  30          


Lys Xaa Xaa Phe Pro Cys Phe Pro Leu Leu Lys Pro Gly Ile Ser Glu 
        35                  40                  45              


Gly Ser Ser Arg Asp His Pro Arg Arg Lys Gln Leu Ile Leu Xaa Ser 
    50                  55                  60                  


Leu Leu Gln Asp Leu Leu 
65                  70  


<210> 3015
<211> 196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<400> 3015
Met Phe Asp Arg Asn Ile Trp Pro Lys Arg Gln Arg Gln Asn Asn Phe 
1               5                   10                  15      


Pro Met Phe Pro Ser Pro Lys Ala Trp Asn Phe Arg Gly Arg Lys Arg 
            20                  25                  30          


Lys Gln Ser Xaa Gln Asp Glu Asp Ala Val Ser Leu Cys Ser Leu Asp 
        35                  40                  45              


Ile Ser Glu Pro Ser Asn Lys Arg Val Lys Pro Leu Ser Arg Val Xaa 
    50                  55                  60                  


Ser Leu Ala Asn Leu Ile Pro Pro Val Lys Ala Xaa Pro Leu Lys Arg 
65                  70                  75                  80  


Phe Ser Gln Xaa Leu Gln Arg Ser Ile Ser Phe Arg Ser Glu Ser Arg 
                85                  90                  95      


Pro Asp Ile Leu Ala Pro Arg Pro Trp Ser Arg Asn Ala Ala Pro Ser 
            100                 105                 110         


Ser Xaa Lys Arg Arg Asp Ser Lys Leu Trp Ser Glu Xaa Phe Asp Val 
        115                 120                 125             


Cys Val Asn Gln Met Leu Xaa Ser Lys Glu Ile Lys Arg Gln Glu Ala 
    130                 135                 140                 


Ile Phe Glu Leu Ser Gln Gly Glu Glu Asp Leu Ile Glu Asp Leu Lys 
145                 150                 155                 160 


Leu Ala Lys Lys Ala Tyr His Asp Pro Met Leu Lys Leu Ser Ile Met 
                165                 170                 175     


Xaa Glu Gln Glu Leu Asn Gln Ile Phe Gly Xaa Leu Asp Ser Leu Ile 
            180                 185                 190         


Pro Leu His Glu 
        195     


<210> 3016
<211> 184
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<400> 3016
Met Phe Pro Ser Pro Lys Ala Trp Asn Phe Arg Gly Arg Lys Arg Lys 
1               5                   10                  15      


Gln Ser Xaa Gln Asp Glu Asp Ala Val Ser Leu Cys Ser Leu Asp Ile 
            20                  25                  30          


Ser Glu Pro Ser Asn Lys Arg Val Lys Pro Leu Ser Arg Val Xaa Ser 
        35                  40                  45              


Leu Ala Asn Leu Ile Pro Pro Val Lys Ala Xaa Pro Leu Lys Arg Phe 
    50                  55                  60                  


Ser Gln Xaa Leu Gln Arg Ser Ile Ser Phe Arg Ser Glu Ser Arg Pro 
65                  70                  75                  80  


Asp Ile Leu Ala Pro Arg Pro Trp Ser Arg Asn Ala Ala Pro Ser Ser 
                85                  90                  95      


Xaa Lys Arg Arg Asp Ser Lys Leu Trp Ser Glu Xaa Phe Asp Val Cys 
            100                 105                 110         


Val Asn Gln Met Leu Xaa Ser Lys Glu Ile Lys Arg Gln Glu Ala Ile 
        115                 120                 125             


Phe Glu Leu Ser Gln Gly Glu Glu Asp Leu Ile Glu Asp Leu Lys Leu 
    130                 135                 140                 


Ala Lys Lys Ala Tyr His Asp Pro Met Leu Lys Leu Ser Ile Met Xaa 
145                 150                 155                 160 


Glu Gln Glu Leu Asn Gln Ile Phe Gly Xaa Leu Asp Ser Leu Ile Pro 
                165                 170                 175     


Leu His Glu Glu Leu Leu Ser Gln 
            180                 


<210> 3017
<211> 497
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<400> 3017
Met Ile Glu Glu Pro Ser Asn Lys Arg Val Lys Pro Leu Ser Arg Val 
1               5                   10                  15      


Xaa Ser Leu Ala Asn Leu Ile Pro Pro Val Lys Ala Xaa Pro Leu Lys 
            20                  25                  30          


Arg Phe Ser Gln Xaa Leu Gln Arg Ser Ile Ser Phe Arg Ser Glu Ser 
        35                  40                  45              


Arg Pro Asp Ile Leu Ala Pro Arg Pro Trp Ser Arg Asn Ala Ala Pro 
    50                  55                  60                  


Ser Ser Xaa Lys Arg Arg Asp Ser Lys Leu Trp Ser Glu Xaa Phe Asp 
65                  70                  75                  80  


Val Cys Val Asn Gln Met Leu Xaa Ser Lys Glu Ile Lys Arg Gln Glu 
                85                  90                  95      


Ala Ile Phe Glu Leu Ser Gln Gly Glu Glu Asp Leu Ile Glu Asp Leu 
            100                 105                 110         


Lys Leu Ala Lys Lys Ala Tyr His Asp Pro Met Leu Lys Leu Ser Ile 
        115                 120                 125             


Met Xaa Glu Gln Glu Leu Asn Gln Ile Phe Gly Xaa Leu Asp Ser Leu 
    130                 135                 140                 


Ile Pro Leu His Glu Glu Leu Leu Ser Gln Leu Arg Asp Val Arg Lys 
145                 150                 155                 160 


Pro Asp Gly Ser Xaa Glu His Val Gly Pro Ile Leu Val Gly Trp Leu 
                165                 170                 175     


Pro Cys Leu Ser Ser Tyr Asp Ser Tyr Cys Ser Asn Gln Val Ala Ala 
            180                 185                 190         


Lys Ala Leu Leu Asp His Lys Lys Gln Asp His Arg Val Gln Asp Phe 
        195                 200                 205             


Leu Gln Arg Cys Leu Glu Ser Pro Phe Ser Arg Lys Leu Asp Leu Trp 
    210                 215                 220                 


Asn Phe Leu Asp Ile Pro Arg Ser Arg Leu Val Lys Tyr Pro Leu Leu 
225                 230                 235                 240 


Leu Arg Glu Ile Leu Arg His Xaa Pro Asn Asp Asn Pro Asp Gln Gln 
                245                 250                 255     


His Leu Glu Glu Ala Ile Asn Ile Ile Gln Gly Ile Val Ala Glu Ile 
            260                 265                 270         


Asn Xaa Lys Xaa Gly Glu Ser Glu Cys Arg Tyr Tyr Lys Glu Arg Leu 
        275                 280                 285             


Leu Tyr Leu Glu Glu Gly Gln Lys Asp Ser Leu Ile Asp Ser Ser Arg 
    290                 295                 300                 


Val Leu Cys Cys His Gly Glu Leu Lys Asn Asn Arg Gly Val Lys Leu 
305                 310                 315                 320 


His Val Phe Leu Phe Gln Glu Val Leu Val Ile Xaa Arg Ala Val Xaa 
                325                 330                 335     


His Asn Glu Gln Leu Cys Tyr Gln Leu Tyr Arg Gln Pro Ile Pro Val 
            340                 345                 350         


Lys Asp Leu Leu Leu Glu Asp Leu Gln Asp Gly Glu Val Arg Leu Gly 
        355                 360                 365             


Gly Ser Leu Arg Gly Ala Phe Ser Asn Asn Glu Arg Ile Lys Asn Phe 
    370                 375                 380                 


Phe Arg Val Ser Phe Lys Asn Gly Ser Gln Ser Gln Xaa His Ser Leu 
385                 390                 395                 400 


Gln Ala Asn Asp Xaa Phe Asn Lys Gln Gln Trp Leu Asn Cys Ile Arg 
                405                 410                 415     


Gln Ala Lys Glu Xaa Val Leu Cys Ala Ala Gly Gln Ala Gly Val Leu 
            420                 425                 430         


Asp Ser Glu Gly Ser Phe Leu Asn Pro Xaa Xaa Gly Ser Arg Glu Leu 
        435                 440                 445             


Gln Gly Glu Xaa Lys Leu Glu Gln Met Asp Gln Ser Asp Ser Glu Ser 
    450                 455                 460                 


Asp Cys Ser Met Asp Xaa Ser Glu Val Ser Leu Asp Cys Glu Arg Met 
465                 470                 475                 480 


Glu Gln Xaa Asp Ser Ser Cys Gly Asn Ser Arg His Gly Glu Ser Asn 
                485                 490                 495     


Val 
    


<210> 3018
<211> 532
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<400> 3018
Met Ile Glu Val Cys His His Asn Trp Leu Leu Trp Leu Cys Pro Ser 
1               5                   10                  15      


Lys Phe Gly Ile Phe Met Cys Cys Leu Ala Ser Xaa Xaa Gly Gln Met 
            20                  25                  30          


Glu Leu Arg Arg Xaa Arg Glu Pro Ser Asn Lys Arg Val Lys Pro Leu 
        35                  40                  45              


Ser Arg Val Xaa Ser Leu Ala Asn Leu Ile Pro Pro Val Lys Ala Xaa 
    50                  55                  60                  


Pro Leu Lys Arg Phe Ser Gln Xaa Leu Gln Arg Ser Ile Ser Phe Arg 
65                  70                  75                  80  


Ser Glu Ser Arg Pro Asp Ile Leu Ala Pro Arg Pro Trp Ser Arg Asn 
                85                  90                  95      


Ala Ala Pro Ser Ser Xaa Lys Arg Arg Asp Ser Lys Leu Trp Ser Glu 
            100                 105                 110         


Xaa Phe Asp Val Cys Val Asn Gln Met Leu Xaa Ser Lys Glu Ile Lys 
        115                 120                 125             


Arg Gln Glu Ala Ile Phe Glu Leu Ser Gln Gly Glu Glu Asp Leu Ile 
    130                 135                 140                 


Glu Asp Leu Lys Leu Ala Lys Lys Ala Tyr His Asp Pro Met Leu Lys 
145                 150                 155                 160 


Leu Ser Ile Met Xaa Glu Gln Glu Leu Asn Gln Ile Phe Gly Xaa Leu 
                165                 170                 175     


Asp Ser Leu Ile Pro Leu His Glu Glu Leu Leu Ser Gln Leu Arg Asp 
            180                 185                 190         


Val Arg Lys Pro Asp Gly Ser Xaa Glu His Val Gly Pro Ile Leu Val 
        195                 200                 205             


Gly Trp Leu Pro Cys Leu Ser Ser Tyr Asp Ser Tyr Cys Ser Asn Gln 
    210                 215                 220                 


Val Ala Ala Lys Ala Leu Leu Asp His Lys Lys Gln Asp His Arg Val 
225                 230                 235                 240 


Gln Asp Phe Leu Gln Arg Cys Leu Glu Ser Pro Phe Ser Arg Lys Leu 
                245                 250                 255     


Asp Leu Trp Asn Phe Leu Asp Ile Pro Arg Ser Arg Leu Val Lys Tyr 
            260                 265                 270         


Pro Leu Leu Leu Arg Glu Ile Leu Arg His Xaa Pro Asn Asp Asn Pro 
        275                 280                 285             


Asp Gln Gln His Leu Glu Glu Ala Ile Asn Ile Ile Gln Gly Ile Val 
    290                 295                 300                 


Ala Glu Ile Asn Xaa Lys Xaa Gly Glu Ser Glu Cys Arg Tyr Tyr Lys 
305                 310                 315                 320 


Glu Arg Leu Leu Tyr Leu Glu Glu Gly Gln Lys Asp Ser Leu Ile Asp 
                325                 330                 335     


Ser Ser Arg Val Leu Cys Cys His Gly Glu Leu Lys Asn Asn Arg Gly 
            340                 345                 350         


Val Lys Leu His Val Phe Leu Phe Gln Glu Val Leu Val Ile Xaa Arg 
        355                 360                 365             


Ala Val Xaa His Asn Glu Gln Leu Cys Tyr Gln Leu Tyr Arg Gln Pro 
    370                 375                 380                 


Ile Pro Val Lys Asp Leu Leu Leu Glu Asp Leu Gln Asp Gly Glu Val 
385                 390                 395                 400 


Arg Leu Gly Gly Ser Leu Arg Gly Ala Phe Ser Asn Asn Glu Arg Ile 
                405                 410                 415     


Lys Asn Phe Phe Arg Val Ser Phe Lys Asn Gly Ser Gln Ser Gln Xaa 
            420                 425                 430         


His Ser Leu Gln Ala Asn Asp Xaa Phe Asn Lys Gln Gln Trp Leu Asn 
        435                 440                 445             


Cys Ile Arg Gln Ala Lys Glu Xaa Val Leu Cys Ala Ala Gly Gln Ala 
    450                 455                 460                 


Gly Val Leu Asp Ser Glu Gly Ser Phe Leu Asn Pro Xaa Xaa Gly Ser 
465                 470                 475                 480 


Arg Glu Leu Gln Gly Glu Xaa Lys Leu Glu Gln Met Asp Gln Ser Asp 
                485                 490                 495     


Ser Glu Ser Asp Cys Ser Met Asp Xaa Ser Glu Val Ser Leu Asp Cys 
            500                 505                 510         


Glu Arg Met Glu Gln Xaa Asp Ser Ser Cys Gly Asn Ser Arg His Gly 
        515                 520                 525             


Glu Ser Asn Val 
    530         


<210> 3019
<211> 532
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<400> 3019
Met Arg Ser Glu Arg Pro Met Val Trp Cys Cys Leu Phe Val Arg Ser 
1               5                   10                  15      


Gln Arg Lys Arg Lys Gln Ser Xaa Gln Asp Glu Asp Ala Val Ser Leu 
            20                  25                  30          


Cys Ser Leu Asp Ile Ser Glu Pro Ser Asn Lys Arg Val Lys Pro Leu 
        35                  40                  45              


Ser Arg Val Xaa Ser Leu Ala Asn Leu Ile Pro Pro Val Lys Ala Xaa 
    50                  55                  60                  


Pro Leu Lys Arg Phe Ser Gln Xaa Leu Gln Arg Ser Ile Ser Phe Arg 
65                  70                  75                  80  


Ser Glu Ser Arg Pro Asp Ile Leu Ala Pro Arg Pro Trp Ser Arg Asn 
                85                  90                  95      


Ala Ala Pro Ser Ser Xaa Lys Arg Arg Asp Ser Lys Leu Trp Ser Glu 
            100                 105                 110         


Xaa Phe Asp Val Cys Val Asn Gln Met Leu Xaa Ser Lys Glu Ile Lys 
        115                 120                 125             


Arg Gln Glu Ala Ile Phe Glu Leu Ser Gln Gly Glu Glu Asp Leu Ile 
    130                 135                 140                 


Glu Asp Leu Lys Leu Ala Lys Lys Ala Tyr His Asp Pro Met Leu Lys 
145                 150                 155                 160 


Leu Ser Ile Met Xaa Glu Gln Glu Leu Asn Gln Ile Phe Gly Xaa Leu 
                165                 170                 175     


Asp Ser Leu Ile Pro Leu His Glu Glu Leu Leu Ser Gln Leu Arg Asp 
            180                 185                 190         


Val Arg Lys Pro Asp Gly Ser Xaa Glu His Val Gly Pro Ile Leu Val 
        195                 200                 205             


Gly Trp Leu Pro Cys Leu Ser Ser Tyr Asp Ser Tyr Cys Ser Asn Gln 
    210                 215                 220                 


Val Ala Ala Lys Ala Leu Leu Asp His Lys Lys Gln Asp His Arg Val 
225                 230                 235                 240 


Gln Asp Phe Leu Gln Arg Cys Leu Glu Ser Pro Phe Ser Arg Lys Leu 
                245                 250                 255     


Asp Leu Trp Asn Phe Leu Asp Ile Pro Arg Ser Arg Leu Val Lys Tyr 
            260                 265                 270         


Pro Leu Leu Leu Arg Glu Ile Leu Arg His Xaa Pro Asn Asp Asn Pro 
        275                 280                 285             


Asp Gln Gln His Leu Glu Glu Ala Ile Asn Ile Ile Gln Gly Ile Val 
    290                 295                 300                 


Ala Glu Ile Asn Xaa Lys Xaa Gly Glu Ser Glu Cys Arg Tyr Tyr Lys 
305                 310                 315                 320 


Glu Arg Leu Leu Tyr Leu Glu Glu Gly Gln Lys Asp Ser Leu Ile Asp 
                325                 330                 335     


Ser Ser Arg Val Leu Cys Cys His Gly Glu Leu Lys Asn Asn Arg Gly 
            340                 345                 350         


Val Lys Leu His Val Phe Leu Phe Gln Glu Val Leu Val Ile Xaa Arg 
        355                 360                 365             


Ala Val Xaa His Asn Glu Gln Leu Cys Tyr Gln Leu Tyr Arg Gln Pro 
    370                 375                 380                 


Ile Pro Val Lys Asp Leu Leu Leu Glu Asp Leu Gln Asp Gly Glu Val 
385                 390                 395                 400 


Arg Leu Gly Gly Ser Leu Arg Gly Ala Phe Ser Asn Asn Glu Arg Ile 
                405                 410                 415     


Lys Asn Phe Phe Arg Val Ser Phe Lys Asn Gly Ser Gln Ser Gln Xaa 
            420                 425                 430         


His Ser Leu Gln Ala Asn Asp Xaa Phe Asn Lys Gln Gln Trp Leu Asn 
        435                 440                 445             


Cys Ile Arg Gln Ala Lys Glu Xaa Val Leu Cys Ala Ala Gly Gln Ala 
    450                 455                 460                 


Gly Val Leu Asp Ser Glu Gly Ser Phe Leu Asn Pro Xaa Xaa Gly Ser 
465                 470                 475                 480 


Arg Glu Leu Gln Gly Glu Xaa Lys Leu Glu Gln Met Asp Gln Ser Asp 
                485                 490                 495     


Ser Glu Ser Asp Cys Ser Met Asp Xaa Ser Glu Val Ser Leu Asp Cys 
            500                 505                 510         


Glu Arg Met Glu Gln Xaa Asp Ser Ser Cys Gly Asn Ser Arg His Gly 
        515                 520                 525             


Glu Ser Asn Val 
    530         


<210> 3020
<211> 416
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<400> 3020
Met Val Ala Lys Asp Tyr Pro Phe Tyr Leu Xaa Val Lys Arg Ala Asn 
1               5                   10                  15      


Cys Ser Leu Glu Leu Pro Pro Ala Ser Gly Pro Ala Lys Asp Ala Glu 
            20                  25                  30          


Glu Pro Ser Asn Lys Arg Val Lys Pro Leu Ser Arg Val Xaa Ser Leu 
        35                  40                  45              


Ala Asn Leu Ile Pro Pro Val Lys Ala Xaa Pro Leu Lys Arg Phe Ser 
    50                  55                  60                  


Gln Xaa Leu Gln Arg Ser Ile Ser Phe Arg Ser Glu Ser Arg Pro Asp 
65                  70                  75                  80  


Ile Leu Ala Pro Arg Pro Trp Ser Arg Asn Ala Ala Pro Ser Ser Xaa 
                85                  90                  95      


Lys Arg Arg Asp Ser Lys Leu Trp Ser Glu Xaa Phe Asp Val Cys Val 
            100                 105                 110         


Asn Gln Met Leu Xaa Ser Lys Glu Ile Lys Arg Gln Glu Ala Ile Phe 
        115                 120                 125             


Glu Leu Ser Gln Gly Glu Glu Asp Leu Ile Glu Asp Leu Lys Leu Ala 
    130                 135                 140                 


Lys Lys Ala Tyr His Asp Pro Met Leu Lys Leu Ser Ile Met Xaa Glu 
145                 150                 155                 160 


Gln Glu Leu Asn Gln Ile Phe Gly Xaa Leu Asp Ser Leu Ile Pro Leu 
                165                 170                 175     


His Glu Glu Leu Leu Ser Gln Leu Arg Asp Val Arg Lys Pro Asp Gly 
            180                 185                 190         


Ser Xaa Glu His Val Gly Pro Ile Leu Val Gly Trp Leu Pro Cys Leu 
        195                 200                 205             


Ser Ser Tyr Asp Ser Tyr Cys Ser Asn Gln Val Ala Ala Lys Ala Leu 
    210                 215                 220                 


Leu Asp His Lys Lys Gln Asp His Arg Val Gln Asp Phe Leu Gln Arg 
225                 230                 235                 240 


Cys Leu Glu Ser Pro Phe Ser Arg Lys Leu Asp Leu Trp Asn Phe Leu 
                245                 250                 255     


Asp Ile Pro Arg Ser Arg Leu Val Lys Tyr Pro Leu Leu Leu Arg Glu 
            260                 265                 270         


Ile Leu Arg His Xaa Pro Asn Asp Asn Pro Asp Gln Gln His Leu Glu 
        275                 280                 285             


Glu Ala Ile Asn Ile Ile Gln Gly Ile Val Ala Glu Ile Asn Xaa Lys 
    290                 295                 300                 


Xaa Gly Glu Ser Glu Cys Arg Tyr Tyr Lys Glu Arg Leu Leu Tyr Leu 
305                 310                 315                 320 


Glu Glu Gly Gln Lys Asp Ser Leu Ile Asp Ser Ser Arg Val Leu Cys 
                325                 330                 335     


Cys His Gly Glu Leu Lys Asn Asn Arg Gly Val Lys Leu His Val Phe 
            340                 345                 350         


Leu Phe Gln Glu Val Leu Val Ile Xaa Arg Ala Val Xaa His Asn Glu 
        355                 360                 365             


Gln Leu Cys Tyr Gln Leu Tyr Arg Gln Pro Ile Pro Val Lys Asp Leu 
    370                 375                 380                 


Leu Leu Glu Asp Leu Gln Asp Gly Glu Val Arg Leu Gly Gly Ser Leu 
385                 390                 395                 400 


Arg Gly Ala Phe Ser Asn Asn Glu Arg Ser Met Asp Ser Ser Arg Gly 
                405                 410                 415     


<210> 3021
<211> 526
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<400> 3021
Met Val Ala Lys Asp Tyr Pro Phe Tyr Leu Xaa Val Lys Arg Ala Asn 
1               5                   10                  15      


Cys Ser Leu Glu Leu Pro Pro Ala Ser Gly Pro Ala Lys Asp Ala Glu 
            20                  25                  30          


Glu Pro Ser Asn Lys Arg Val Lys Pro Leu Ser Arg Val Xaa Ser Leu 
        35                  40                  45              


Ala Asn Leu Ile Pro Pro Val Lys Ala Xaa Pro Leu Lys Arg Phe Ser 
    50                  55                  60                  


Gln Xaa Leu Gln Arg Ser Ile Ser Phe Arg Ser Glu Ser Arg Pro Asp 
65                  70                  75                  80  


Ile Leu Ala Pro Arg Pro Trp Ser Arg Asn Ala Ala Pro Ser Ser Xaa 
                85                  90                  95      


Lys Arg Arg Asp Ser Lys Leu Trp Ser Glu Xaa Phe Asp Val Cys Val 
            100                 105                 110         


Asn Gln Met Leu Xaa Ser Lys Glu Ile Lys Arg Gln Glu Ala Ile Phe 
        115                 120                 125             


Glu Leu Ser Gln Gly Glu Glu Asp Leu Ile Glu Asp Leu Lys Leu Ala 
    130                 135                 140                 


Lys Lys Ala Tyr His Asp Pro Met Leu Lys Leu Ser Ile Met Xaa Glu 
145                 150                 155                 160 


Gln Glu Leu Asn Gln Ile Phe Gly Xaa Leu Asp Ser Leu Ile Pro Leu 
                165                 170                 175     


His Glu Glu Leu Leu Ser Gln Leu Arg Asp Val Arg Lys Pro Asp Gly 
            180                 185                 190         


Ser Xaa Glu His Val Gly Pro Ile Leu Val Gly Trp Leu Pro Cys Leu 
        195                 200                 205             


Ser Ser Tyr Asp Ser Tyr Cys Ser Asn Gln Val Ala Ala Lys Ala Leu 
    210                 215                 220                 


Leu Asp His Lys Lys Gln Asp His Arg Val Gln Asp Phe Leu Gln Arg 
225                 230                 235                 240 


Cys Leu Glu Ser Pro Phe Ser Arg Lys Leu Asp Leu Trp Asn Phe Leu 
                245                 250                 255     


Asp Ile Pro Arg Ser Arg Leu Val Lys Tyr Pro Leu Leu Leu Arg Glu 
            260                 265                 270         


Ile Leu Arg His Xaa Pro Asn Asp Asn Pro Asp Gln Gln His Leu Glu 
        275                 280                 285             


Glu Ala Ile Asn Ile Ile Gln Gly Ile Val Ala Glu Ile Asn Xaa Lys 
    290                 295                 300                 


Xaa Gly Glu Ser Glu Cys Arg Tyr Tyr Lys Glu Arg Leu Leu Tyr Leu 
305                 310                 315                 320 


Glu Glu Gly Gln Lys Asp Ser Leu Ile Asp Ser Ser Arg Val Leu Cys 
                325                 330                 335     


Cys His Gly Glu Leu Lys Asn Asn Arg Gly Val Lys Leu His Val Phe 
            340                 345                 350         


Leu Phe Gln Glu Val Leu Val Ile Xaa Arg Ala Val Xaa His Asn Glu 
        355                 360                 365             


Gln Leu Cys Tyr Gln Leu Tyr Arg Gln Pro Ile Pro Val Lys Asp Leu 
    370                 375                 380                 


Leu Leu Glu Asp Leu Gln Asp Gly Glu Val Arg Leu Gly Gly Ser Leu 
385                 390                 395                 400 


Arg Gly Ala Phe Ser Asn Asn Glu Arg Ile Lys Asn Phe Phe Arg Val 
                405                 410                 415     


Ser Phe Lys Asn Gly Ser Gln Ser Gln Xaa His Ser Leu Gln Ala Asn 
            420                 425                 430         


Asp Xaa Phe Asn Lys Gln Gln Trp Leu Asn Cys Ile Arg Gln Ala Lys 
        435                 440                 445             


Glu Xaa Val Leu Cys Ala Ala Gly Gln Ala Gly Val Leu Asp Ser Glu 
    450                 455                 460                 


Gly Ser Phe Leu Asn Pro Xaa Xaa Gly Ser Arg Glu Leu Gln Gly Glu 
465                 470                 475                 480 


Xaa Lys Leu Glu Gln Met Asp Gln Ser Asp Ser Glu Ser Asp Cys Ser 
                485                 490                 495     


Met Asp Xaa Ser Glu Val Ser Leu Asp Cys Glu Arg Met Glu Gln Xaa 
            500                 505                 510         


Asp Ser Ser Cys Gly Asn Ser Arg His Gly Glu Ser Asn Val 
        515                 520                 525     


<210> 3022
<211> 236
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<400> 3022
Xaa Val Glu Ser Cys Pro Ala Arg Ser Arg Leu Ser Val Ser Val Ser 
1               5                   10                  15      


Pro Pro Pro Pro Gly Ile Val Glu Leu Gly Pro Pro Phe Ala Trp Glu 
            20                  25                  30          


Phe Cys Ser Arg Leu Gly Ser Ala Val Xaa Ser Gln Arg Ala Gly Pro 
        35                  40                  45              


Ala Ala Ala Met Val Ala Lys Asp Tyr Pro Phe Tyr Leu Xaa Val Lys 
    50                  55                  60                  


Arg Ala Asn Cys Ser Leu Glu Leu Pro Pro Ala Ser Gly Pro Ala Lys 
65                  70                  75                  80  


Asp Ala Glu Glu Pro Ser Asn Lys Arg Val Lys Pro Leu Ser Arg Val 
                85                  90                  95      


Xaa Ser Leu Ala Asn Leu Ile Pro Pro Val Lys Ala Xaa Pro Leu Lys 
            100                 105                 110         


Arg Phe Ser Gln Xaa Leu Gln Arg Ser Ile Ser Phe Arg Ser Glu Ser 
        115                 120                 125             


Arg Pro Asp Ile Leu Ala Pro Arg Pro Trp Ser Arg Asn Ala Ala Pro 
    130                 135                 140                 


Ser Ser Xaa Lys Arg Arg Asp Ser Lys Leu Trp Ser Glu Xaa Phe Asp 
145                 150                 155                 160 


Val Cys Val Asn Gln Met Leu Xaa Ser Lys Glu Ile Lys Arg Gln Glu 
                165                 170                 175     


Ala Ile Phe Glu Leu Ser Gln Gly Glu Glu Asp Leu Ile Glu Asp Leu 
            180                 185                 190         


Lys Leu Ala Lys Lys Ala Tyr His Asp Pro Met Leu Lys Leu Ser Ile 
        195                 200                 205             


Met Xaa Glu Gln Glu Leu Asn Gln Ile Phe Gly Xaa Leu Asp Ser Leu 
    210                 215                 220                 


Ile Pro Leu His Glu Ala Pro Leu Pro Gln Leu Leu 
225                 230                 235     


<210> 3023
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<400> 3023
Gly Arg Ala Pro Ile Lys Ala Glu Arg Ala Ala Gln Ala His Gly Pro 
1               5                   10                  15      


Ala Ala Ala Ala Val Ala Ala Arg Gly Ala Ser Arg Xaa Phe Phe Pro 
            20                  25                  30          


Gln Gln Arg Ser Gln Ser Glu Lys Gln Xaa Tyr Leu Glu Glu Met His 
        35                  40                  45              


Leu Glu Asp Xaa Xaa Arg Phe Cys Pro Lys Glu Glu Arg Glu Ser Glu 
    50                  55                  60                  


Gln Xaa Ser Phe Ser Asp Gln Asn Pro Arg Gln Asp Gln Lys Gly Gly 
65                  70                  75                  80  


Phe Arg Ser Ser Phe Arg Lys Leu Phe Lys Lys Lys Asn Gly Asn Ala 
                85                  90                  95      


Xaa Gly Glu Asp Phe Cys Gly Pro Trp Gly Trp Trp 
            100                 105             


<210> 3024
<211> 870
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<400> 3024
Met Glu Lys Xaa Lys Xaa Lys Gln Gly Glu Asn Glu His Met Pro Val 
1               5                   10                  15      


Asn Asn Pro Ser Xaa Gln Ile Tyr Gln Leu Gln Ala Leu Ala Ser Glu 
            20                  25                  30          


Leu Lys Xaa Gly Phe Xaa Glu Ala Met Gln Glu Leu Ser Arg Ile Gln 
        35                  40                  45              


His Gly Glu Tyr Ala Leu Glu Glu Lys Val Lys Ser Cys Arg Cys Ser 
    50                  55                  60                  


Met Glu Glu Lys Val Xaa Glu Met Lys Asn Ser Leu Asn Tyr Phe Lys 
65                  70                  75                  80  


Glu Glu Leu Ser Asn Ala Met Ser Met Ile Gln Ala Ile Xaa Ser Lys 
                85                  90                  95      


Gln Glu Glu Met Gln Gln Lys Ile Glu Gln Leu Gln Gln Glu Lys Arg 
            100                 105                 110         


Arg Glu Ser Arg Lys Val Lys Ala Lys Lys Xaa Gln Lys Glu Glu His 
        115                 120                 125             


Ser Ser Gln Ala Gly Pro Ala Gln Ala Gln Gly Ser Pro Phe Arg Ser 
    130                 135                 140                 


Ile Asn Ile Pro Glu Pro Val Leu Pro Ser Glu Asp Phe Xaa Asn Leu 
145                 150                 155                 160 


Leu Pro Ser Gln Ala Tyr Glu Lys Ala Gln Glu Ser Arg Ser Val His 
                165                 170                 175     


Val Gly Asp Ser Asn Val Lys Gly Met Met Gly Pro Gly Val Asn Pro 
            180                 185                 190         


Xaa Xaa Pro Glu Ala Glu Glu Asn Leu Lys Ser Cys Leu Ser Ala Asp 
        195                 200                 205             


Ile Gln Ser Lys Gly His Leu Pro Ser Gly Met Trp Arg Gln Pro Lys 
    210                 215                 220                 


Asp Gly Lys Glu Trp Gly Glu Glu Tyr Val Xaa Lys Asp His Pro Asp 
225                 230                 235                 240 


Lys Leu Lys Glu Ala Gly Gln Gly Arg His Ser Ser Leu Glu Asn Val 
                245                 250                 255     


Leu Cys Glu Xaa Ser Leu Ala Ala Lys Arg Gln Xaa Val Ala Leu Glu 
            260                 265                 270         


Leu Leu Glu Ser Glu Arg Lys Tyr Val Ile Asn Ile Ser Leu Ile Leu 
        275                 280                 285             


Lys Ile Lys Ala Xaa Phe Gln Gly Ser Asp Gly Lys Arg Asn Ser Lys 
    290                 295                 300                 


Glu Arg Ser Leu Phe Pro Gly Ser Leu Arg Tyr Leu Val Gln Gln His 
305                 310                 315                 320 


Leu Asp Leu Leu His Ala Leu Gln Glu Arg Val Leu Lys Trp Pro Arg 
                325                 330                 335     


Gln Gly Val Leu Gly Asp Leu Phe Leu Lys Leu Xaa Asn Asp Glu Asn 
            340                 345                 350         


Asn Phe Leu Asp Tyr Tyr Val Ala Tyr Leu Arg Asp Leu Pro Glu Cys 
        355                 360                 365             


Ile Ser Leu Val His Val Val Val Leu Lys Glu Gly Asp Glu Glu Ile 
    370                 375                 380                 


Lys Ser Asp Ile Tyr Xaa Leu Phe Phe His Ile Val Gln Arg Ile Pro 
385                 390                 395                 400 


Glu Tyr Leu Ile His Leu Gln Asn Val Leu Lys Phe Xaa Glu Gln Glu 
                405                 410                 415     


His Pro Asp Tyr Tyr Leu Leu Leu Val Cys Val Gln Arg Leu Arg Val 
            420                 425                 430         


Phe Ile Ser His Tyr Xaa Leu Leu Phe Gln Cys Asn Glu Asp Leu Leu 
        435                 440                 445             


Ile Gln Lys Arg Lys Lys Leu Lys Lys Ser Ser Met Ala Lys Leu Tyr 
    450                 455                 460                 


Lys Gly Leu Ala Ser Gln Cys Ala Asn Ala Gly Gln Asp Ala Ser Pro 
465                 470                 475                 480 


Xaa Ala Gly Pro Glu Ala Val Arg Asp Xaa Gly Ile His Ser Glu Glu 
                485                 490                 495     


Leu Leu Gln Pro Tyr Pro Ser Ala Pro Ser Ser Gly Pro Ala Ile Xaa 
            500                 505                 510         


His Leu Met Pro Pro Val Lys Lys Ser Gln Gln Gln Gln Ser Leu Met 
        515                 520                 525             


Glu Ser Met Gln Pro Gly Lys Pro Ser Asp Trp Glu Leu Glu Gly Arg 
    530                 535                 540                 


Lys His Glu Arg Pro Glu Ser Leu Leu Ala Pro Xaa Gln Phe Cys Ala 
545                 550                 555                 560 


Ala Glu Gln Asp Val Lys Ala Leu Ala Gly Pro Leu Gln Ala Ile Pro 
                565                 570                 575     


Glu Met Asp Phe Glu Ser Ser Pro Ala Glu Pro Leu Gly Asn Val Glu 
            580                 585                 590         


Arg Ser Leu Arg Ala Pro Ala Glu Leu Leu Pro Asp Ala Arg Gly Phe 
        595                 600                 605             


Val Pro Ala Ala Tyr Glu Glu Phe Glu Tyr Gly Gly Glu Ile Phe Ala 
    610                 615                 620                 


Leu Pro Ala Pro Tyr Asp Glu Glu Pro Phe Gln Ala Pro Ala Leu Phe 
625                 630                 635                 640 


Glu Asn Cys Ser Pro Ala Ser Ser Glu Ser Ser Leu Asp Ile Cys Phe 
                645                 650                 655     


Leu Arg Pro Val Ser Phe Ala Met Glu Ala Glu Arg Pro Glu His Pro 
            660                 665                 670         


Leu Gln Pro Leu Pro Lys Ser Ala Xaa Ser Pro Ala Gly Ser Ser Ser 
        675                 680                 685             


Ala Tyr Lys Leu Glu Ala Ala Ala Gln Ala His Gly Lys Ala Lys Pro 
    690                 695                 700                 


Leu Ser Arg Ser Leu Lys Glu Phe Pro Arg Ala Pro Pro Ala Asp Gly 
705                 710                 715                 720 


Val Ala Pro Arg Leu Tyr Ser Xaa Arg Ser Ser Ser Gly Gly Arg Ala 
                725                 730                 735     


Pro Ile Lys Ala Glu Arg Ala Ala Gln Ala His Gly Pro Ala Ala Ala 
            740                 745                 750         


Ala Val Ala Ala Arg Gly Ala Ser Arg Xaa Phe Phe Pro Gln Gln Arg 
        755                 760                 765             


Ser Gln Ser Glu Lys Gln Xaa Tyr Leu Glu Val Arg Arg Glu Met His 
    770                 775                 780                 


Leu Glu Asp Xaa Xaa Arg Phe Cys Pro Lys Glu Glu Arg Glu Ser Glu 
785                 790                 795                 800 


Gln Xaa Ser Phe Ser Asp Gln Asn Pro Arg Gln Asp Gln Lys Gly Gly 
                805                 810                 815     


Phe Arg Ser Ser Phe Arg Lys Leu Phe Lys Lys Lys Ser Ser Gly Ser 
            820                 825                 830         


Glu Tyr Arg Glu Lys Xaa Asn Glu Asn Pro Ser Met Asp Pro Ser Pro 
        835                 840                 845             


Xaa Lys Gln Asp Phe Phe Arg Asn Arg Leu Ala Leu Ala Asn Asp Leu 
    850                 855                 860                 


Asp Gln Gly Xaa Ala Val 
865                 870 


<210> 3025
<211> 109
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 3025
Xaa Gly Arg Ala Pro Ile Lys Ala Glu Arg Ala Ala Gln Ala His Gly 
1               5                   10                  15      


Pro Ala Ala Ala Ala Val Ala Ala Arg Gly Ala Ser Arg Xaa Phe Phe 
            20                  25                  30          


Pro Gln Gln Arg Ser Gln Ser Glu Lys Gln Xaa Tyr Leu Glu Glu Met 
        35                  40                  45              


His Leu Glu Asp Xaa Xaa Arg Phe Cys Pro Lys Glu Glu Arg Glu Ser 
    50                  55                  60                  


Glu Gln Xaa Ser Phe Ser Asp Gln Asn Pro Arg Gln Asp Gln Lys Gly 
65                  70                  75                  80  


Gly Phe Arg Ser Ser Phe Arg Lys Leu Phe Lys Lys Lys Asn Gly Asn 
                85                  90                  95      


Ala Xaa Gly Glu Asp Phe Cys Gly Pro Trp Gly Trp Trp 
            100                 105                 


<210> 3026
<211> 103
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 3026
Met Ala Lys His Gly Ala Asp Glu Pro Ser Ser Arg Ser Gly Ser Pro 
1               5                   10                  15      


Asp Arg Glu Gly Arg Ala Ser Glu Asp Arg Ser Leu Leu His Gln Arg 
            20                  25                  30          


Leu Ala Val Arg Glu Leu Ile Asp Xaa Glu Val Ser Tyr Leu His Met 
        35                  40                  45              


Leu Gln Leu Cys Ala Ser Asp Ile Arg Ser Arg Leu Gln Gln Leu Pro 
    50                  55                  60                  


Gln Gly Asp Leu Asp Val Leu Phe Ser Asn Ile Asp Asp Ile Ile Lys 
65                  70                  75                  80  


Val Asn Ser Arg Phe Leu His Asp Leu Gln Glu Xaa Ala Ser Lys Glu 
                85                  90                  95      


Glu Glu Gln Val Gln Leu Val 
            100             


<210> 3027
<211> 675
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<400> 3027
Met Ala Lys His Gly Ala Asp Glu Pro Ser Ser Arg Ser Gly Ser Pro 
1               5                   10                  15      


Asp Arg Glu Gly Arg Ala Ser Glu Asp Arg Ser Leu Leu His Gln Arg 
            20                  25                  30          


Leu Ala Val Arg Glu Leu Ile Asp Xaa Glu Val Ser Tyr Leu His Met 
        35                  40                  45              


Leu Gln Leu Cys Ala Ser Asp Ile Arg Ser Arg Leu Gln Gln Leu Pro 
    50                  55                  60                  


Gln Gly Asp Leu Asp Val Leu Phe Ser Asn Ile Asp Asp Ile Ile Lys 
65                  70                  75                  80  


Val Asn Ser Arg Phe Leu His Asp Leu Gln Glu Xaa Ala Ser Lys Glu 
                85                  90                  95      


Glu Glu Gln Val Gln Leu Val Gly Asn Ile Phe Leu Glu Phe Gln Glu 
            100                 105                 110         


Glu Leu Glu Gln Val Tyr Lys Val Tyr Cys Ala Ser Tyr Asp Gln Ala 
        115                 120                 125             


Leu Leu Leu Val Asp Xaa Tyr Arg Lys Glu Pro Glu Leu Gln Arg His 
    130                 135                 140                 


Ile Gln Gly Ile Val Glu Ala Val Val Pro Gln Ala Gly Ser Ser Gly 
145                 150                 155                 160 


Leu Ser Phe Leu Leu Val Ile Pro Leu Gln Arg Ile Xaa Arg Tyr Pro 
                165                 170                 175     


Leu Leu Leu Gln Lys Ile Leu Glu Asn Xaa Val Pro Asp Ala Ser Ala 
            180                 185                 190         


Tyr Pro Val Leu Gln Arg Ala Val Ser Ala Leu Gln Asp Val Asn Xaa 
        195                 200                 205             


Asn Ile Asn Glu Tyr Lys Met Arg Lys Glu Val Ala Ser Lys Tyr Xaa 
    210                 215                 220                 


Lys Val Glu Gln Leu Xaa Leu Arg Glu Arg Leu Ala Arg Ile Asn Xaa 
225                 230                 235                 240 


His Xaa Leu Ser Lys Lys Xaa Xaa Arg Leu Ser Gln Leu Leu Lys Gln 
                245                 250                 255     


Glu Ala Gly Leu Ile Pro Arg Xaa Glu Asp Lys Glu Phe Asp Asp Leu 
            260                 265                 270         


Glu Glu Arg Phe Gln Trp Val Ser Leu Cys Val Xaa Glu Leu Lys Asn 
        275                 280                 285             


Asn Val Ala Ala Tyr Leu Asp Asn Leu Gln Ala Phe Leu Tyr Phe Arg 
    290                 295                 300                 


Pro His Glu Tyr Asn Leu Asp Ile Pro Glu Gly Pro Ala Val Gln Tyr 
305                 310                 315                 320 


Cys Asn Leu Ala Arg Asp Leu His Leu Glu Ala Phe Leu Lys Phe Lys 
                325                 330                 335     


Gln Arg Leu Glu Gly Leu Val Trp Gln Pro Leu Cys Ser Leu Ala Lys 
            340                 345                 350         


Ala Leu Leu Gly Pro Gln Asn Leu Ile Lys Lys Arg Leu Asp Lys Leu 
        355                 360                 365             


Leu Asp Phe Glu Arg Val Glu Glu Lys Leu Leu Glu Val Gly Ser Val 
    370                 375                 380                 


Xaa Tyr Gln Glu Glu Ala Ala Arg His Xaa Tyr Gln Ala Leu Asn Ser 
385                 390                 395                 400 


Leu Leu Val Ala Glu Leu Pro Gln Phe Asn Gln Leu Val Met Gln Trp 
                405                 410                 415     


Leu Gly Gln Ile Met Cys Xaa Phe Val Xaa Leu Gln Arg Asp Leu Ala 
            420                 425                 430         


Lys Gln Val Leu Gln Arg Ala Glu Gly Ser Met Ala Gln Leu Pro His 
        435                 440                 445             


His His Val Pro Glu Pro Ala Phe Arg Lys Leu Val Glu Asp Ala Leu 
    450                 455                 460                 


Gly Arg Xaa Ser Asn Gln Leu Arg Ser Phe Gln Glu Xaa Phe Glu Lys 
465                 470                 475                 480 


Val Gln Pro Pro Pro Xaa Xaa Gln Pro Leu Leu Pro Gly Ser Glu Arg 
                485                 490                 495     


Gln Val Gln Ala Leu Leu Ser Arg Tyr Gly Pro Gly Lys Leu Tyr Gln 
            500                 505                 510         


Val Xaa Ser Asn Ile Ser Gly Xaa Gly Xaa Leu Asp Leu Xaa Leu Pro 
        515                 520                 525             


Arg Gly Gln Ile Val Ala Ile Leu Gln Asn Lys Asp Xaa Lys Gly Asn 
    530                 535                 540                 


Ser Gly Arg Trp Leu Val Asp Xaa Gly Gly His Arg Gly Tyr Val Pro 
545                 550                 555                 560 


Ala Gly Lys Leu Gln Leu Tyr His Val Val Pro Ser Ala Glu Glu Leu 
                565                 570                 575     


Arg Arg Gln Ala Gly Leu Asn Lys Asp Pro Arg Cys Leu Xaa Pro Glu 
            580                 585                 590         


Pro Ser Pro Ala Leu Val Pro Ser Ile Pro Xaa Met Asn Gln Val Ile 
        595                 600                 605             


Ala Ala Tyr Pro Phe Val Ala Arg Ser Ser His Glu Val Ser Leu Gln 
    610                 615                 620                 


Ala Gly Gln Pro Val Xaa Ile Leu Glu Ala Gln Asp Lys Lys Gly Asn 
625                 630                 635                 640 


Pro Glu Trp Ser Leu Val Glu Val Asn Gly Gln Arg Gly Tyr Val Pro 
                645                 650                 655     


Ser Gly Phe Leu Ala Arg Ala Arg Ser Pro Val Leu Trp Gly Trp Ser 
            660                 665                 670         


Leu Pro Ser 
        675 


<210> 3028
<211> 219
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(160)
<223> Selenocysteine

<400> 3028
Met Glu Pro Lys Glu Ala Xaa Gly Lys Glu Asn Met Val Xaa Lys Lys 
1               5                   10                  15      


Lys Asn Leu Ala Phe Leu Arg Ser Arg Leu Tyr Met Leu Glu Arg Arg 
            20                  25                  30          


Lys Xaa Asp Xaa Val Val Glu Ser Ser Val Ser Gly Asp His Ser Gly 
        35                  40                  45              


Xaa Leu Arg Arg Ser Gln Ser Asp Arg Xaa Glu Tyr Asn Gln Lys Leu 
    50                  55                  60                  


Gln Glu Lys Met Xaa Pro Gln Gly Glu Cys Ser Val Ala Glu Xaa Leu 
65                  70                  75                  80  


Xaa Pro Glu Glu Glu His His Met Lys Arg Met Met Ala Lys Arg Glu 
                85                  90                  95      


Lys Ile Ile Lys Glu Leu Ile Gln Xaa Glu Lys Asp Tyr Leu Asn Asp 
            100                 105                 110         


Leu Glu Leu Cys Val Arg Glu Val Val Gln Pro Leu Arg Asn Lys Lys 
        115                 120                 125             


Xaa Asp Arg Leu Asp Val Asp Ser Leu Phe Ser Asn Ile Glu Ser Val 
    130                 135                 140                 


His Gln Ile Ser Ala Lys Leu Leu Ser Leu Leu Glu Glu Ala Xaa Xaa 
145                 150                 155                 160 


Asp Val Glu Pro Ala Met Gln Val Ile Gly Glu Val Phe Leu Gln Ile 
                165                 170                 175     


Lys Gly Pro Leu Glu Asp Ile Tyr Lys Ile Tyr Cys Tyr His His Asp 
            180                 185                 190         


Glu Ala His Ser Ile Leu Glu Ser Tyr Glu Lys Glu Glu Glu Leu Lys 
        195                 200                 205             


Glu His Leu Ser His Cys Ile Gln Ser Leu Lys 
    210                 215                 


<210> 3029
<211> 777
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<400> 3029
Met Glu Pro Lys Glu Ala Xaa Gly Lys Glu Asn Met Val Xaa Lys Lys 
1               5                   10                  15      


Lys Asn Leu Ala Phe Leu Arg Ser Arg Leu Tyr Met Leu Glu Arg Arg 
            20                  25                  30          


Lys Xaa Asp Xaa Val Val Glu Ser Ser Val Ser Gly Asp His Ser Gly 
        35                  40                  45              


Xaa Leu Arg Arg Ser Gln Ser Asp Arg Xaa Glu Tyr Asn Gln Lys Leu 
    50                  55                  60                  


Gln Glu Lys Met Xaa Pro Gln Gly Glu Cys Ser Val Ala Glu Xaa Leu 
65                  70                  75                  80  


Xaa Pro Glu Glu Glu His His Met Lys Arg Met Met Ala Lys Arg Glu 
                85                  90                  95      


Lys Ile Ile Lys Glu Leu Ile Gln Xaa Glu Lys Asp Tyr Leu Asn Asp 
            100                 105                 110         


Leu Glu Leu Cys Val Arg Glu Val Val Gln Pro Leu Arg Asn Lys Lys 
        115                 120                 125             


Xaa Asp Arg Leu Asp Val Asp Ser Leu Phe Ser Asn Ile Glu Ser Val 
    130                 135                 140                 


His Gln Ile Ser Ala Lys Leu Leu Ser Leu Leu Glu Glu Ala Xaa Xaa 
145                 150                 155                 160 


Asp Val Glu Pro Ala Met Gln Val Ile Gly Glu Val Phe Leu Gln Ile 
                165                 170                 175     


Lys Gly Pro Leu Glu Asp Ile Tyr Lys Ile Tyr Cys Tyr His His Asp 
            180                 185                 190         


Glu Ala His Ser Ile Leu Glu Ser Tyr Glu Lys Glu Glu Glu Leu Lys 
        195                 200                 205             


Glu His Leu Ser His Cys Ile Gln Ser Leu Lys Lys Ile Tyr Met Gln 
    210                 215                 220                 


Glu Gly Lys Pro Asn Leu Leu Asp Met Gly Ser Leu Met Ile Lys Pro 
225                 230                 235                 240 


Ile Gln Arg Val Met Lys Tyr Pro Leu Leu Leu Cys Glu Leu Arg Asn 
                245                 250                 255     


Ser Xaa Pro Pro Ser His Pro Asp Tyr Arg Ala Leu Asp Asp Ala Phe 
            260                 265                 270         


Ala Ala Val Lys Asp Ile Asn Val Asn Ile Asn Glu Leu Lys Arg Arg 
        275                 280                 285             


Lys Asp Leu Val Leu Lys Tyr Lys Lys Asn Asp Glu Asp Glu Ser Leu 
    290                 295                 300                 


Lys Asp Lys Leu Ser Lys Leu Asn Ile His Ser Ile Ser Lys Lys Ser 
305                 310                 315                 320 


Lys Arg Val Xaa Asn His Leu Lys Ile Leu Xaa Arg Gly Glu Ser Gln 
                325                 330                 335     


Val Lys Asp Asn Xaa Phe Asn Arg Glu Glu Lys Leu Phe Arg Ala Leu 
            340                 345                 350         


Glu Lys Xaa Val Arg Leu Cys Val Lys Asn Ile Ser Leu Cys Leu Gln 
        355                 360                 365             


His Ile Gln Asp Ala Met Pro Leu Ala Leu Gln Ser Val Met Asp Leu 
    370                 375                 380                 


Gln Glu Ile Ser Tyr Asn Lys Asp Asp Glu Met Asp Tyr Ser Glu Xaa 
385                 390                 395                 400 


Leu Ser Asn Ala Leu Asn Ser Cys His Asp Phe Ala Ser His Leu Gln 
                405                 410                 415     


Arg Leu Ile Leu Xaa Pro Leu Ser Ala Leu Leu Ser Leu Phe Pro Gly 
            420                 425                 430         


Pro His Lys Leu Ile Gln Lys Arg Tyr Asp Lys Leu Leu Asp Cys Asn 
        435                 440                 445             


Ser Tyr Leu Gln Arg Ser Xaa Gly Glu Glu Ser Asp Leu Ala Lys Lys 
    450                 455                 460                 


Glu Tyr Glu Ala Leu Asn Ala Gln Leu Val Glu Glu Leu Gln Ala Phe 
465                 470                 475                 480 


Asn Gln Ala Ala Arg Lys Ile Leu Leu Asn Cys Leu Cys Ser Phe Ile 
                485                 490                 495     


Xaa Leu Leu Arg Asp Leu Met Leu Val Ala Gln Gln Ala Tyr Ser Xaa 
            500                 505                 510         


Leu Val Pro Met Pro Leu Leu Val Ser Ser Ile Ser Glu Ile Gln Asn 
        515                 520                 525             


Gln Val Leu Glu Glu Ile Gln Asn Leu Asn Cys Val Lys Glu Asn Ser 
    530                 535                 540                 


Ala Xaa Phe Ile Glu Arg Lys Leu Ser Phe Glu Lys Lys Lys Pro Val 
545                 550                 555                 560 


Gln Ile Leu Pro Glu Met Pro His Gln Xaa Asp Ile His Arg Ser Lys 
                565                 570                 575     


Leu Leu Ser Xaa Tyr Ser Ala Glu Glu Leu Tyr Gln Ala Lys Arg Lys 
            580                 585                 590         


Cys Asn Ala Xaa Gln Glu Tyr Asp Ile Asn Leu Leu Glu Gly Asp Leu 
        595                 600                 605             


Val Ala Val Ile Glu Gln Lys Asp Pro Leu Gly Ser Xaa Ser Arg Trp 
    610                 615                 620                 


Leu Val Asp Xaa Gly Asn Val Lys Gly Tyr Val Tyr Ser Ser Phe Leu 
625                 630                 635                 640 


Lys Pro Tyr Asn Pro Ala Lys Met Gln Lys Val Asp Ala Glu Asn Arg 
                645                 650                 655     


Phe Cys Asp Asp Asp Phe Glu Asn Ile Ser Leu Phe Val Ser Ser Arg 
            660                 665                 670         


Pro Ala Ser Asp Ser Val Xaa Gly Xaa Ser Glu Ser Ser Ile Gly Asp 
        675                 680                 685             


Ser Ser Ser Ser Leu Ser Gly Xaa Cys Gly Lys Phe Glu Xaa Asn Gly 
    690                 695                 700                 


Xaa Asp Val Asp Ser Phe Gln Glu Val Asp Glu Gln Ile Phe Tyr Ala 
705                 710                 715                 720 


Val His Ala Phe Gln Ala Arg Ser Asp His Glu Leu Ser Leu Gln Glu 
                725                 730                 735     


Tyr Gln Arg Val His Ile Leu Arg Phe Cys Asp Leu Ser Gly Asn Lys 
            740                 745                 750         


Glu Trp Trp Leu Ala Glu Ala Gln Gly Gln Lys Gly Tyr Val Pro Ala 
        755                 760                 765             


Asn Tyr Leu Gly Lys Met Xaa Tyr Ala 
    770                 775         


<210> 3030
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<400> 3030
Met Glu Leu Ser Cys Pro Gly Ser Arg Cys Pro Val Gln Glu Gln Arg 
1               5                   10                  15      


Ala Arg Trp Glu Arg Lys Arg Ala Cys Xaa Ala Arg Glu Leu Leu Glu 
            20                  25                  30          


Xaa Glu Arg Arg Tyr Gln Glu Gln Leu Gly Leu Val Ala Xaa Tyr Phe 
        35                  40                  45              


Leu Gly Ile Leu Lys Ala Lys Gly Xaa Leu Arg Pro Pro Glu Arg Gln 
    50                  55                  60                  


Ala Leu Phe Gly Ser Trp Glu Leu Ile Tyr Gly Ala Ser Gln Glu Leu 
65                  70                  75                  80  


Leu Pro Tyr Leu Glu Gly Gly Cys Trp Gly Gln Gly Leu Glu Gly Phe 
                85                  90                  95      


Cys Arg His Leu Glu Leu Tyr Asn Gln Phe Ala Ala Asn Ser Glu Arg 
            100                 105                 110         


Ser Gln Xaa Xaa Leu Gln Glu Gln Leu Lys Lys Asn Lys Gly Phe Arg 
        115                 120                 125             


Arg Phe Val Arg Leu Gln Glu Gly Arg Pro Glu Phe Gly Gly Leu Gln 
    130                 135                 140                 


Leu Gln Asp Leu Leu Pro Leu Pro Leu Gln Arg Leu Gln Gln Tyr Glu 
145                 150                 155                 160 


Asn Leu Val Val Ala Leu Ala Glu Asn Xaa Gly Pro Asn Ser Pro Asp 
                165                 170                 175     


His Gln Gln Leu Xaa Pro Val Leu Pro Ser 
            180                 185     


<210> 3031
<211> 335
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<400> 3031
Met Glu Leu Ser Cys Pro Gly Ser Arg Cys Pro Val Gln Glu Gln Arg 
1               5                   10                  15      


Ala Arg Trp Glu Arg Lys Arg Ala Cys Xaa Ala Arg Glu Leu Leu Glu 
            20                  25                  30          


Xaa Glu Arg Arg Tyr Gln Glu Gln Leu Gly Leu Val Ala Xaa Tyr Phe 
        35                  40                  45              


Leu Gly Ile Leu Lys Ala Lys Gly Xaa Leu Arg Pro Pro Glu Arg Gln 
    50                  55                  60                  


Ala Leu Phe Gly Ser Trp Glu Leu Ile Tyr Gly Ala Ser Gln Glu Leu 
65                  70                  75                  80  


Leu Pro Tyr Leu Glu Gly Gly Cys Trp Gly Gln Gly Leu Glu Gly Phe 
                85                  90                  95      


Cys Arg His Leu Glu Leu Tyr Asn Gln Phe Ala Ala Asn Ser Glu Arg 
            100                 105                 110         


Ser Gln Xaa Xaa Leu Gln Glu Gln Leu Lys Lys Asn Lys Gly Phe Arg 
        115                 120                 125             


Arg Phe Val Arg Leu Gln Glu Gly Arg Pro Glu Phe Gly Gly Leu Gln 
    130                 135                 140                 


Leu Gln Asp Leu Leu Pro Leu Pro Leu Gln Arg Leu Gln Gln Tyr Glu 
145                 150                 155                 160 


Asn Leu Val Val Ala Leu Ala Glu Asn Xaa Gly Pro Asn Ser Pro Asp 
                165                 170                 175     


His Gln Gln Leu Xaa Arg Ala Ala Arg Leu Ile Ser Glu Xaa Ala Gln 
            180                 185                 190         


Arg Val His Xaa Ile Gly Gln Lys Gln Lys Asn Asp Gln His Leu Arg 
        195                 200                 205             


Arg Val Gln Ala Leu Leu Ser Gly Arg Gln Ala Lys Gly Leu Xaa Ser 
    210                 215                 220                 


Gly Arg Trp Phe Leu Arg Gln Gly Trp Leu Leu Val Val Pro Pro His 
225                 230                 235                 240 


Gly Glu Pro Arg Pro Arg Met Phe Phe Leu Phe Xaa Asp Val Leu Leu 
                245                 250                 255     


Met Ala Lys Pro Arg Pro Pro Leu His Leu Leu Arg Ser Gly Xaa Phe 
            260                 265                 270         


Ala Cys Lys Ala Leu Tyr Pro Met Ala Gln Cys His Leu Ser Arg Val 
        275                 280                 285             


Phe Gly His Ser Gly Gly Pro Cys Gly Gly Leu Leu Ser Leu Ser Phe 
    290                 295                 300                 


Pro His Glu Lys Leu Leu Leu Met Ser Xaa Asp Gln Glu Glu Leu Ser 
305                 310                 315                 320 


Arg Trp Tyr His Ser Leu Xaa Trp Ala Ile Ser Ser Gln Lys Asn 
                325                 330                 335 


<210> 3032
<211> 299
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<400> 3032
Met Leu Gly Val Cys Gln Xaa Leu Lys Gln Tyr Phe Leu Gly Ile Leu 
1               5                   10                  15      


Lys Ala Lys Gly Xaa Leu Arg Pro Pro Glu Arg Gln Ala Leu Phe Gly 
            20                  25                  30          


Ser Trp Glu Leu Ile Tyr Gly Ala Ser Gln Glu Leu Leu Pro Tyr Leu 
        35                  40                  45              


Glu Gly Gly Cys Trp Gly Gln Gly Leu Glu Gly Phe Cys Arg His Leu 
    50                  55                  60                  


Glu Leu Tyr Asn Gln Phe Ala Ala Asn Ser Glu Arg Ser Gln Xaa Xaa 
65                  70                  75                  80  


Leu Gln Glu Gln Leu Lys Lys Asn Lys Gly Phe Arg Arg Phe Val Arg 
                85                  90                  95      


Leu Gln Glu Gly Arg Pro Glu Phe Gly Gly Leu Gln Leu Gln Asp Leu 
            100                 105                 110         


Leu Pro Leu Pro Leu Gln Arg Leu Gln Gln Tyr Glu Asn Leu Val Val 
        115                 120                 125             


Ala Leu Ala Glu Asn Xaa Gly Pro Asn Ser Pro Asp His Gln Gln Leu 
    130                 135                 140                 


Xaa Arg Ala Ala Arg Leu Ile Ser Glu Xaa Ala Gln Arg Val His Xaa 
145                 150                 155                 160 


Ile Gly Gln Lys Gln Lys Asn Asp Gln His Leu Arg Arg Val Gln Ala 
                165                 170                 175     


Leu Leu Ser Gly Arg Gln Ala Lys Gly Leu Xaa Ser Gly Arg Trp Phe 
            180                 185                 190         


Leu Arg Gln Gly Trp Leu Leu Val Val Pro Pro His Gly Glu Pro Arg 
        195                 200                 205             


Pro Arg Met Phe Phe Leu Phe Xaa Asp Val Leu Leu Met Ala Lys Pro 
    210                 215                 220                 


Arg Pro Pro Leu His Leu Leu Arg Ser Gly Xaa Phe Ala Cys Lys Ala 
225                 230                 235                 240 


Leu Tyr Pro Met Ala Gln Cys His Leu Ser Arg Val Phe Gly His Ser 
                245                 250                 255     


Gly Gly Pro Cys Gly Gly Leu Leu Ser Leu Ser Phe Pro His Glu Lys 
            260                 265                 270         


Leu Leu Leu Met Ser Xaa Asp Gln Glu Glu Leu Ser Arg Trp Tyr His 
        275                 280                 285             


Ser Leu Xaa Trp Ala Ile Ser Ser Gln Lys Asn 
    290                 295                 


<210> 3033
<211> 56
<212> PRT
<213> Homo sapiens

<400> 3033
Met Ala Arg Ala Pro Gln Pro Arg Arg Gly Pro Ala Ala Pro Gly Asn 
1               5                   10                  15      


Ala Leu Arg Ala Leu Leu Arg Cys Asn Leu Pro Pro Gly Ala Gln Arg 
            20                  25                  30          


Val Val Val Ser Ala Val Leu Ala Leu Leu Val Leu Ile Asn Val Val 
        35                  40                  45              


Leu Ile Phe Leu Leu Ala Phe Arg 
    50                  55      


<210> 3034
<211> 1816
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1173)..(1173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1222)..(1222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1260)..(1260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1291)..(1291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1294)..(1294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1314)..(1314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1325)..(1325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1328)..(1328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1393)..(1393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1413)..(1413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1481)..(1481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1548)..(1548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1567)..(1567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1636)..(1636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1706)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1714)..(1714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1745)..(1745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1762)..(1762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1775)..(1775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1803)..(1803)
<223> Selenocysteine

<400> 3034
Met Leu Ser Val Val His Phe Leu Arg Ser Phe Phe Lys Xaa Pro Glu 
1               5                   10                  15      


Pro Gly Ala His Leu Pro Gly Glu Gly Glu Ile Glu Asp Asn Gln Leu 
            20                  25                  30          


Pro Xaa Ser Pro Ala Glu Gln Val Glu Gln Gly Trp Asn Gln Gln Xaa 
        35                  40                  45              


Asp Arg Asp Asp Ser Glu Xaa Leu Ser Gln Gln Ser Glu Ser Gly Ser 
    50                  55                  60                  


Asp Xaa Lys Xaa Asp Pro Phe Glu Ser Ala Ser Asp Xaa Glu Ser Leu 
65                  70                  75                  80  


Ser Gly Tyr Leu Pro Arg Gly Val Phe His Pro Leu Arg Gly Xaa Pro 
                85                  90                  95      


Val Asp Ile Glu Ala Pro Trp Glu Tyr Pro Asp Val Ser Ala Xaa Gly 
            100                 105                 110         


Pro Pro Gln Glu Gln His Leu Xaa Ser Val Pro Gly Leu His Ala Lys 
        115                 120                 125             


Glu Glu Leu Asp Leu Ser Pro Ser Leu Glu Asp Asp Ser Cys Lys Asn 
    130                 135                 140                 


Gly Trp Arg Ala Phe Ala Xaa Val Ala Gly Glu Gln Glu Ala Gly His 
145                 150                 155                 160 


Leu Trp Asp Cys Ala Xaa Ser Leu Glu Arg Glu Ser Leu Leu Ala Gly 
                165                 170                 175     


Val Pro Arg His Xaa Gly Cys Cys Leu Gln Arg Ala Xaa Asp Ser Ser 
            180                 185                 190         


Gly Pro Glu Pro Val Gln Gly Val Ala Val Gln Asp Leu Arg Gly Leu 
        195                 200                 205             


Ser Ser Val Ser Leu Gln Lys Ser Arg Ser Glu Ser Tyr Leu Gly Ile 
    210                 215                 220                 


Pro Val Val Trp Pro Phe Leu Leu Trp Cys Cys Glu Leu Gly Arg Ser 
225                 230                 235                 240 


Trp Pro His Ile His Asn Arg Ala Arg Ala Leu Val Leu Pro Ser Arg 
                245                 250                 255     


Gly Pro Leu Asp Asn Xaa Ala Pro Leu Gly Xaa Arg Xaa Lys Lys Glu 
            260                 265                 270         


Ser Xaa Leu Gly Pro Ala Gly Asp Xaa Glu Leu Leu Trp Ser Gln Pro 
        275                 280                 285             


His Ser Asp Val Pro Cys Gln Pro Pro Leu Arg Xaa Ser Cys Leu Leu 
    290                 295                 300                 


Arg Xaa Asn Arg His His Ser Ala Pro Glu Xaa Xaa Gly Asp Lys Asn 
305                 310                 315                 320 


Arg Ala Ser Pro Arg Leu Asn Cys Gly His Met Arg Ala Leu Val Arg 
                325                 330                 335     


Ala His Ser Ile Ala Gly Phe Ser Pro Glu Cys Pro Glu Asp Pro Val 
            340                 345                 350         


Gly Gln Asn Val Val Lys Ser Gly Xaa His Val Lys Glu Gly Ala Lys 
        355                 360                 365             


Asn Glu Arg Asp Pro Arg Ile Gln Asn Ile Pro Ser Pro Ala Pro Xaa 
    370                 375                 380                 


Gln Leu Ser Gly Pro Ile Pro Ala Phe Gln Ser Gly Ala Pro His Leu 
385                 390                 395                 400 


Gln Gly Pro Cys Lys Pro Gly Gly Phe Arg Leu Gln Arg Ala Ser Gln 
                405                 410                 415     


Asp Xaa Pro Ser Ala Gly Leu Leu Gly Glu Asn Gln Leu Arg Gln Asp 
            420                 425                 430         


Ser Arg Ser Cys Leu Val Ala Ser Cys Leu Xaa Ser Glu Leu Val Lys 
        435                 440                 445             


Leu Ser Ala Glu Glu Val Pro Glu Pro Ala Glu Cys Lys Ser Glu Gln 
    450                 455                 460                 


Ser Pro Glu Ser Arg Xaa Gln Glu Pro Gln Gly Xaa Gln Leu Ala Pro 
465                 470                 475                 480 


Arg Ala Ala Asp Glu Arg Glu Xaa Gln Lys His Leu Trp Gly Ile Ser 
                485                 490                 495     


Val Gln Ala Gly Asn Gln Xaa Ser Asn Tyr Xaa Ser Lys Tyr Val Leu 
            500                 505                 510         


Ser Glu Glu Ser Lys Ser Pro Xaa Arg Ala Lys Phe Pro Arg Gln Pro 
        515                 520                 525             


Ser Ser Glu Gly Xaa Gln Val Trp Ser Gly Asp Leu Met Gly Cys Leu 
    530                 535                 540                 


Glu Val Ser Asp Ser Ser Asp Ala Pro Glu Xaa Xaa Gln Lys Ser Ser 
545                 550                 555                 560 


Ala Ile Asp Xaa Ser Lys Ala Ala Glu Glu Ala Met Val Leu Asp Pro 
                565                 570                 575     


Asn Tyr Arg Glu Gln Ala Leu Gln Gly Leu Ser Glu Phe Lys Ala Ala 
            580                 585                 590         


Xaa Val Ser His Cys Gly Pro Gly Ala Glu Glu Gly Glu Gln Gly Pro 
        595                 600                 605             


Gly Gly Ala Gly Gly Arg Gln Leu Glu Pro Lys Ala Gly Gly Glu Ala 
    610                 615                 620                 


Ser Arg Gly Arg Gly Ala Leu Ile Ile Val Ala Val Glu Gln Lys Gly 
625                 630                 635                 640 


Leu Gln Ala Ser Arg Ser Asn Ala Gly Pro Val Pro Glu Xaa Leu Pro 
                645                 650                 655     


Arg Asp Phe Pro Lys Glu Arg Pro Glu Ser Pro Leu Ser Xaa Gly Glu 
            660                 665                 670         


Xaa Pro Cys Glu Ser Pro Xaa Arg Gly Lys Xaa Pro Ala Gly Asn Glu 
        675                 680                 685             


Cys Glu Leu Pro Ala Ala Pro Ile Gln Gly Ala Gly Asp Gly Ala Leu 
    690                 695                 700                 


Gln Arg Val Ala Gln Ala Ala Glu Leu Gly Arg Val Leu Val Pro Gln 
705                 710                 715                 720 


Ala Ala Ser Glu Glu Xaa Pro Ser Xaa Glu Glu Pro Pro Gly Glu Arg 
                725                 730                 735     


Leu Arg Gly Glu Ser Arg Ser Ser Gly Ser Gly Glu Arg Gly Pro Glu 
            740                 745                 750         


Glu Ala Pro Glu Gly Gly Ala Ala Ala Ala Arg Gly Gln Arg Pro Arg 
        755                 760                 765             


Val Pro Ala Leu Glu Pro Pro Gln Pro Pro Arg Gly Leu Arg Lys Gly 
    770                 775                 780                 


Ala Gln Glu Pro Gly Lys Arg Pro Xaa Phe Ser Lys Val Xaa Ser Phe 
785                 790                 795                 800 


Arg Lys Gly Arg Pro Leu Ala Xaa Glu Ser Pro Gly Gly Val Pro Ala 
                805                 810                 815     


Pro Xaa Xaa Glu Gly Arg Arg Trp Gly Ser Ser Gly Pro Glu Gly Leu 
            820                 825                 830         


Pro Arg Glu Asn Pro Pro Ala Ala Ala Gly Arg Asp Ala Pro Pro Leu 
        835                 840                 845             


His His Gly Asp Ala Ser Ala Trp Pro Glu Phe Val Pro Gln Ala Ala 
    850                 855                 860                 


Gly Asp Arg Xaa Ala Gly Pro Ala Gly Ala Gly His Xaa Gly Xaa Ser 
865                 870                 875                 880 


Gly Asp Leu Gly Ser Arg Gly Pro Ser Ser Glu Ser Cys Asn Ala Lys 
                885                 890                 895     


Arg Leu Lys Xaa Xaa Glu Lys Lys Leu Arg Ala Arg Leu Ala Leu Ala 
            900                 905                 910         


His Lys Xaa Phe Ser Asn Phe Ile Glu Ser Ile Val Leu Glu Lys Glu 
        915                 920                 925             


Asn Xaa His Glu Arg Ser Pro Ser Ser Pro Lys Gly Glu Lys Glu Lys 
    930                 935                 940                 


Ser Arg Leu Arg Gln Gly Ser Trp Arg Ala Phe Leu Lys Ser Lys Asp 
945                 950                 955                 960 


Ala Gly Ser Pro Lys Lys Pro Xaa Leu Val Ser Leu Pro Leu Gly Pro 
                965                 970                 975     


Glu Val Leu Ser Pro Ala Glu Xaa Asp Ser His Cys Glu Glu Arg Ala 
            980                 985                 990         


Glu Asp Lys Glu Gly Tyr Val Phe  Ser Asp His Trp Ala  Pro Pro Leu 
        995                 1000                 1005             


Ala Ser  Xaa Pro Leu Ser Ser  Ser Leu Val Ser Pro  Glu His Arg 
    1010                 1015                 1020             


Arg Lys  Ser Glu Pro Xaa Ile  Lys Cys Xaa Ala Xaa  Gln Glu Gly 
    1025                 1030                 1035             


Gly Arg  Tyr Leu Pro Ser Gly  Ile Phe Pro Glu Lys  Ser Trp Leu 
    1040                 1045                 1050             


Ala Ser  Pro Gly Ser Pro Arg  Ala Gln Gln Ala Gly  Ile Ala His 
    1055                 1060                 1065             


Xaa Leu  Pro Ser Ser Ser Ala  Cys Cys Leu Ala Tyr  Glu Asn Pro 
    1070                 1075                 1080             


Gly Xaa  Pro Cys Arg Pro Xaa  Ser Pro Lys Pro Leu  Ser Pro Arg 
    1085                 1090                 1095             


Pro Ser  Ala Gln Arg Met Gly  Leu His Tyr Pro Gly  Arg Gly Ser 
    1100                 1105                 1110             


Ala Ile  Ser Met Val Ser Leu  Gly Ser Tyr Ser Tyr  Val Asp Ser 
    1115                 1120                 1125             


Ser Ser  Gly Asp Pro Glu Arg  Pro Lys Ile Pro Lys  Gly Gln Xaa 
    1130                 1135                 1140             


Ser Phe  Leu Leu Ser Leu Gln  Xaa Leu Asn Gln Asp  Glu Gln Lys 
    1145                 1150                 1155             


Glu Glu  Ser Arg Glu Gly Gly  Gln Gly Pro Arg Gly  Leu Gly Xaa 
    1160                 1165                 1170             


Val Pro  Trp Leu Arg Asp Leu  Pro Gly Ser Glu Asn  His Met Pro 
    1175                 1180                 1185             


Trp Glu  Glu Pro Ala Gly Glu  Lys Pro Ser Cys Ser  His Ser Gln 
    1190                 1195                 1200             


Lys Ala  Phe His Met Glu Pro  Ala Gln Lys Pro Cys  Phe Xaa Xaa 
    1205                 1210                 1215             


Asp Met  Val Xaa Trp Ala Leu  Leu Cys Ile Ser Ala  Glu Xaa Val 
    1220                 1225                 1230             


Arg Gly  Glu Ala Pro Ser Gln  Pro Arg Gly Ile Pro  His Arg Ser 
    1235                 1240                 1245             


Pro Val  Ser Val Asp Asp Leu  Trp Leu Glu Lys Xaa  Gln Arg Lys 
    1250                 1255                 1260             


Lys Leu  Gln Lys Gln Ala His  Val Glu Arg Arg Leu  His Ile Gly 
    1265                 1270                 1275             


Ala Val  His Lys Asp Gly Val  Lys Cys Trp Arg Lys  Xaa Ile Ile 
    1280                 1285                 1290             


Xaa Ser  Pro Glu Ser Leu Asn  Leu Pro Arg Arg Ser  His Pro Leu 
    1295                 1300                 1305             


Ser Gln  Ser Ala Pro Xaa Gly  Leu Asn His Met Gly  Trp Pro Glu 
    1310                 1315                 1320             


His Xaa  Pro Gly Xaa Ala Met  Pro Asp Gly Ala Leu  Asp Xaa Ala 
    1325                 1330                 1335             


Val Cys  Ala Asp Glu Val Gly  Ser Glu Glu Asp Leu  Tyr Asp Asp 
    1340                 1345                 1350             


Leu His  Ser Ser Ser His His  Tyr Ser His Pro Gly  Gly Gly Gly 
    1355                 1360                 1365             


Glu Gln  Leu Ala Ile Asn Glu  Leu Ile Ser Asp Gly  Ser Val Val 
    1370                 1375                 1380             


Cys Ala  Glu Ala Leu Trp Asp  His Val Xaa Met Asp  Asp Gln Glu 
    1385                 1390                 1395             


Leu Gly  Phe Lys Ala Gly Asp  Val Ile Glu Val Met  Asp Ala Xaa 
    1400                 1405                 1410             


Asn Arg  Glu Trp Trp Trp Gly  Arg Val Ala Asp Gly  Glu Gly Trp 
    1415                 1420                 1425             


Phe Pro  Ala Ser Phe Val Arg  Leu Arg Val Asn Gln  Asp Glu Pro 
    1430                 1435                 1440             


Ala Asp  Asp Asp Ala Pro Leu  Ala Gly Asn Ser Gly  Ala Glu Asp 
    1445                 1450                 1455             


Gly Gly  Ala Glu Ala Gln Ser  Ser Lys Asp Gln Met  Arg Xaa Asn 
    1460                 1465                 1470             


Val Ile  Asn Glu Ile Leu Ser  Xaa Glu Arg Asp Tyr  Ile Lys His 
    1475                 1480                 1485             


Leu Arg  Asp Ile Cys Glu Gln  Ala Asp Phe Gln Ile  Tyr Ser Glu 
    1490                 1495                 1500             


Tyr Cys  Asn Asn His Pro Asn  Ala Cys Val Glu Leu  Ser Arg Leu 
    1505                 1510                 1515             


Xaa Lys  Leu Ser Lys Tyr Val  Tyr Phe Phe Glu Ala  Cys Arg Leu 
    1520                 1525                 1530             


Leu Gln  Lys Met Ile Asp Ile  Ser Leu Asp Gly Phe  Leu Leu Xaa 
    1535                 1540                 1545             


Pro Val  Gln Lys Ile Cys Lys  Tyr Pro Leu Gln Leu  Ala Glu Leu 
    1550                 1555                 1560             


Leu Lys  Tyr Xaa His Pro Gln  His Arg Asp Phe Lys  Asp Val Glu 
    1565                 1570                 1575             


Ala Ala  Leu His Ala Met Lys  Asn Val Ala Gln Leu  Ile Asn Glu 
    1580                 1585                 1590             


Arg Lys  Arg Arg Leu Glu Asn  Ile Asp Lys Ile Ala  Gln Trp Gln 
    1595                 1600                 1605             


Ser Ser  Ile Glu Asp Trp Glu  Gly Glu Asp Leu Leu  Val Arg Ser 
    1610                 1615                 1620             


Ser Glu  Leu Ile Tyr Ser Gly  Glu Leu Xaa Arg Val  Xaa Gln Pro 
    1625                 1630                 1635             


Gln Ala  Lys Ser Gln Gln Arg  Met Phe Phe Leu Phe  Asp His Gln 
    1640                 1645                 1650             


Leu Ile  Tyr Cys Lys Lys Asp  Leu Leu Arg Arg Asp  Val Leu Tyr 
    1655                 1660                 1665             


Tyr Lys  Gly Arg Leu Asp Met  Asp Gly Leu Glu Val  Val Asp Leu 
    1670                 1675                 1680             


Glu Asp  Gly Lys Asp Arg Asp  Leu His Val Ser Ile  Lys Asn Ala 
    1685                 1690                 1695             


Phe Arg  Leu His Arg Gly Ala  Xaa Gly Asp Ser His  Leu Leu Cys 
    1700                 1705                 1710             


Xaa Arg  Lys Pro Glu Gln Lys  Gln Arg Trp Leu Lys  Ala Phe Ala 
    1715                 1720                 1725             


Arg Glu  Arg Glu Gln Val Gln  Leu Asp Gln Glu Xaa  Gly Phe Ser 
    1730                 1735                 1740             


Ile Xaa  Glu Leu Gln Arg Lys  Gln Ala Met Leu Asn  Ala Ser Lys 
    1745                 1750                 1755             


Gln Gln  Val Xaa Gly Lys Pro  Lys Ala Val Gly Arg  Pro Cys Tyr 
    1760                 1765                 1770             


Leu Xaa  Arg Gln Lys His Pro  Ala Leu Pro Ser Asn  Arg Pro Gln 
    1775                 1780                 1785             


Gln Gln  Val Leu Val Leu Ala  Glu Pro Arg Arg Lys  Pro Ser Xaa 
    1790                 1795                 1800             


Phe Trp  His Ser Ile Ser Arg  Leu Ala Pro Phe Arg  Lys 
    1805                 1810                 1815     


<210> 3035
<211> 630
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<400> 3035
Met Pro Trp Glu Glu Pro Ala Gly Glu Lys Pro Ser Cys Ser His Ser 
1               5                   10                  15      


Gln Lys Ala Phe His Met Glu Pro Ala Gln Lys Pro Cys Phe Xaa Xaa 
            20                  25                  30          


Asp Met Val Xaa Trp Ala Leu Leu Cys Ile Ser Ala Glu Xaa Val Arg 
        35                  40                  45              


Gly Glu Ala Pro Ser Gln Pro Arg Gly Ile Pro His Arg Ser Pro Val 
    50                  55                  60                  


Ser Val Asp Asp Leu Trp Leu Glu Lys Xaa Gln Arg Lys Lys Leu Gln 
65                  70                  75                  80  


Lys Gln Ala His Val Glu Arg Arg Leu His Ile Gly Ala Val His Lys 
                85                  90                  95      


Asp Gly Val Lys Cys Trp Arg Lys Xaa Ile Ile Xaa Ser Pro Glu Ser 
            100                 105                 110         


Leu Asn Leu Pro Arg Arg Ser His Pro Leu Ser Gln Ser Ala Pro Xaa 
        115                 120                 125             


Gly Leu Asn His Met Gly Trp Pro Glu His Xaa Pro Gly Xaa Ala Met 
    130                 135                 140                 


Pro Asp Gly Ala Leu Asp Xaa Ala Val Cys Ala Asp Glu Val Gly Ser 
145                 150                 155                 160 


Glu Glu Asp Leu Tyr Asp Asp Leu His Ser Ser Ser His His Tyr Ser 
                165                 170                 175     


His Pro Gly Gly Gly Gly Glu Gln Leu Ala Ile Asn Glu Leu Ile Ser 
            180                 185                 190         


Asp Gly Ser Val Val Cys Ala Glu Ala Leu Trp Asp His Val Xaa Met 
        195                 200                 205             


Asp Asp Gln Glu Leu Gly Phe Lys Ala Gly Asp Val Ile Glu Val Met 
    210                 215                 220                 


Asp Ala Xaa Asn Arg Glu Trp Trp Trp Gly Arg Val Ala Asp Gly Glu 
225                 230                 235                 240 


Gly Trp Phe Pro Ala Ser Phe Val Arg Leu Arg Val Asn Gln Asp Glu 
                245                 250                 255     


Pro Ala Asp Asp Asp Ala Pro Leu Ala Gly Asn Ser Gly Ala Glu Asp 
            260                 265                 270         


Gly Gly Ala Glu Ala Gln Ser Ser Lys Asp Gln Met Arg Xaa Asn Val 
        275                 280                 285             


Ile Asn Glu Ile Leu Ser Xaa Glu Arg Asp Tyr Ile Lys His Leu Arg 
    290                 295                 300                 


Asp Ile Cys Glu Gln Ala Asp Phe Gln Ile Tyr Ser Glu Tyr Cys Asn 
305                 310                 315                 320 


Asn His Pro Asn Ala Cys Val Glu Leu Ser Arg Leu Xaa Lys Leu Ser 
                325                 330                 335     


Lys Tyr Val Tyr Phe Phe Glu Ala Cys Arg Leu Leu Gln Lys Met Ile 
            340                 345                 350         


Asp Ile Ser Leu Asp Gly Phe Leu Leu Xaa Pro Val Gln Lys Ile Cys 
        355                 360                 365             


Lys Tyr Pro Leu Gln Leu Ala Glu Leu Leu Lys Tyr Xaa His Pro Gln 
    370                 375                 380                 


His Arg Asp Phe Lys Asp Val Glu Ala Ala Leu His Ala Met Lys Asn 
385                 390                 395                 400 


Val Ala Gln Leu Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn Ile Asp 
                405                 410                 415     


Lys Ile Ala Gln Trp Gln Ser Ser Ile Glu Asp Trp Glu Gly Glu Asp 
            420                 425                 430         


Leu Leu Val Arg Ser Ser Glu Leu Ile Tyr Ser Gly Glu Leu Xaa Arg 
        435                 440                 445             


Val Xaa Gln Pro Gln Ala Lys Ser Gln Gln Arg Met Phe Phe Leu Phe 
    450                 455                 460                 


Asp His Gln Leu Ile Tyr Cys Lys Lys Asp Leu Leu Arg Arg Asp Val 
465                 470                 475                 480 


Leu Tyr Tyr Lys Gly Arg Leu Asp Met Asp Gly Leu Glu Val Val Asp 
                485                 490                 495     


Leu Glu Asp Gly Lys Asp Arg Asp Leu His Val Ser Ile Lys Asn Ala 
            500                 505                 510         


Phe Arg Leu His Arg Gly Ala Xaa Gly Asp Ser His Leu Leu Cys Xaa 
        515                 520                 525             


Arg Lys Pro Glu Gln Lys Gln Arg Trp Leu Lys Ala Phe Ala Arg Glu 
    530                 535                 540                 


Arg Glu Gln Val Gln Leu Asp Gln Glu Xaa Gly Phe Ser Ile Xaa Glu 
545                 550                 555                 560 


Leu Gln Arg Lys Gln Ala Met Leu Asn Ala Ser Lys Gln Gln Val Xaa 
                565                 570                 575     


Gly Lys Pro Lys Ala Val Gly Arg Pro Cys Tyr Leu Xaa Arg Gln Lys 
            580                 585                 590         


His Pro Ala Leu Pro Ser Asn Arg Pro Gln Gln Gln Val Leu Val Leu 
        595                 600                 605             


Ala Glu Pro Arg Arg Lys Pro Ser Xaa Phe Trp His Ser Ile Ser Arg 
    610                 615                 620                 


Leu Ala Pro Phe Arg Lys 
625                 630 


<210> 3036
<211> 670
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<400> 3036
Met Pro Trp Glu Glu Pro Ala Gly Glu Lys Pro Ser Cys Ser His Ser 
1               5                   10                  15      


Gln Lys Ala Phe His Met Glu Pro Ala Gln Lys Pro Cys Phe Xaa Xaa 
            20                  25                  30          


Asp Met Val Xaa Trp Ala Leu Leu Cys Ile Ser Ala Glu Xaa Val Arg 
        35                  40                  45              


Gly Glu Ala Pro Ser Gln Pro Arg Gly Ile Pro His Arg Ser Pro Val 
    50                  55                  60                  


Ser Val Asp Asp Leu Trp Leu Glu Lys Xaa Gln Arg Lys Lys Leu Gln 
65                  70                  75                  80  


Lys Gln Ala His Val Glu Arg Arg Leu His Ile Gly Ala Val His Lys 
                85                  90                  95      


Asp Gly Val Lys Cys Trp Arg Lys Xaa Ile Ile Xaa Ser Pro Glu Ser 
            100                 105                 110         


Leu Asn Leu Pro Arg Arg Ser His Pro Leu Ser Gln Ser Ala Pro Xaa 
        115                 120                 125             


Gly Leu Asn His Met Gly Trp Pro Glu His Xaa Pro Gly Xaa Ala Met 
    130                 135                 140                 


Pro Asp Gly Ala Leu Asp Xaa Ala Val Cys Ala Asp Glu Val Gly Ser 
145                 150                 155                 160 


Glu Glu Asp Leu Tyr Asp Asp Leu His Ser Ser Ser His His Tyr Ser 
                165                 170                 175     


His Pro Gly Gly Gly Gly Glu Gln Leu Ala Ile Asn Glu Leu Ile Ser 
            180                 185                 190         


Asp Gly Ser Val Val Cys Ala Glu Ala Leu Trp Asp His Val Xaa Met 
        195                 200                 205             


Asp Asp Gln Glu Leu Gly Phe Lys Ala Gly Asp Val Ile Glu Val Met 
    210                 215                 220                 


Asp Ala Xaa Asn Arg Glu Trp Trp Trp Gly Arg Val Ala Asp Gly Glu 
225                 230                 235                 240 


Gly Trp Phe Pro Ala Ser Phe Val Arg Leu Arg Val Asn Gln Asp Glu 
                245                 250                 255     


Pro Ala Asp Asp Asp Ala Pro Leu Ala Gly Asn Ser Gly Ala Glu Asp 
            260                 265                 270         


Gly Gly Ala Glu Ala Gln Ser Ser Lys Asp Gln Met Arg Xaa Asn Val 
        275                 280                 285             


Ile Asn Glu Ile Leu Ser Xaa Glu Arg Asp Tyr Ile Lys His Leu Arg 
    290                 295                 300                 


Asp Ile Cys Glu Gly Tyr Val Arg Gln Cys Arg Lys Arg Ala Asp Met 
305                 310                 315                 320 


Phe Ser Glu Glu Gln Leu Arg Xaa Ile Phe Gly Asn Ile Glu Asp Ile 
                325                 330                 335     


Tyr Arg Cys Gln Lys Ala Phe Val Lys Ala Leu Glu Gln Arg Phe Asn 
            340                 345                 350         


Arg Glu Arg Pro His Leu Ser Glu Leu Gly Ala Cys Phe Leu Glu His 
        355                 360                 365             


Gln Ala Asp Phe Gln Ile Tyr Ser Glu Tyr Cys Asn Asn His Pro Asn 
    370                 375                 380                 


Ala Cys Val Glu Leu Ser Arg Leu Xaa Lys Leu Ser Lys Tyr Val Tyr 
385                 390                 395                 400 


Phe Phe Glu Ala Cys Arg Leu Leu Gln Lys Met Ile Asp Ile Ser Leu 
                405                 410                 415     


Asp Gly Phe Leu Leu Xaa Pro Val Gln Lys Ile Cys Lys Tyr Pro Leu 
            420                 425                 430         


Gln Leu Ala Glu Leu Leu Lys Tyr Xaa His Pro Gln His Arg Asp Phe 
        435                 440                 445             


Lys Asp Val Glu Ala Ala Leu His Ala Met Lys Asn Val Ala Gln Leu 
    450                 455                 460                 


Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn Ile Asp Lys Ile Ala Gln 
465                 470                 475                 480 


Trp Gln Ser Ser Ile Glu Asp Trp Glu Gly Glu Asp Leu Leu Val Arg 
                485                 490                 495     


Ser Ser Glu Leu Ile Tyr Ser Gly Glu Leu Xaa Arg Val Xaa Gln Pro 
            500                 505                 510         


Gln Ala Lys Ser Gln Gln Arg Met Phe Phe Leu Phe Asp His Gln Leu 
        515                 520                 525             


Ile Tyr Cys Lys Lys Asp Leu Leu Arg Arg Asp Val Leu Tyr Tyr Lys 
    530                 535                 540                 


Gly Arg Leu Asp Met Asp Gly Leu Glu Val Val Asp Leu Glu Asp Gly 
545                 550                 555                 560 


Lys Asp Arg Asp Leu His Val Ser Ile Lys Asn Ala Phe Arg Leu His 
                565                 570                 575     


Arg Gly Ala Xaa Gly Asp Ser His Leu Leu Cys Xaa Arg Lys Pro Glu 
            580                 585                 590         


Gln Lys Gln Arg Trp Leu Lys Ala Phe Ala Arg Glu Arg Glu Gln Val 
        595                 600                 605             


Gln Leu Asp Gln Glu Xaa Gly Phe Ser Ile Xaa Glu Leu Gln Arg Lys 
    610                 615                 620                 


Gln Ala Met Leu Asn Ala Ser Lys Gln Gln Val Xaa Gly Lys Pro Lys 
625                 630                 635                 640 


Gly Arg Arg Xaa Ala Ala Pro Pro Pro Arg Leu Pro Gly Pro Tyr Pro 
                645                 650                 655     


Ala Asp Ile Ile Pro Phe Ser Glu Pro Gln Ser Gln Ala Ser 
            660                 665                 670 


<210> 3037
<211> 690
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<400> 3037
Met Pro Trp Glu Glu Pro Ala Gly Glu Lys Pro Ser Cys Ser His Ser 
1               5                   10                  15      


Gln Lys Ala Phe His Met Glu Pro Ala Gln Lys Pro Cys Phe Xaa Xaa 
            20                  25                  30          


Asp Met Val Xaa Trp Ala Leu Leu Cys Ile Ser Ala Glu Xaa Val Arg 
        35                  40                  45              


Gly Glu Ala Pro Ser Gln Pro Arg Gly Ile Pro His Arg Ser Pro Val 
    50                  55                  60                  


Ser Val Asp Asp Leu Trp Leu Glu Lys Xaa Gln Arg Lys Lys Leu Gln 
65                  70                  75                  80  


Lys Gln Ala His Val Glu Arg Arg Leu His Ile Gly Ala Val His Lys 
                85                  90                  95      


Asp Gly Val Lys Cys Trp Arg Lys Xaa Ile Ile Xaa Ser Pro Glu Ser 
            100                 105                 110         


Leu Asn Leu Pro Arg Arg Ser His Pro Leu Ser Gln Ser Ala Pro Xaa 
        115                 120                 125             


Gly Leu Asn His Met Gly Trp Pro Glu His Xaa Pro Gly Xaa Ala Met 
    130                 135                 140                 


Pro Asp Gly Ala Leu Asp Xaa Ala Val Cys Ala Asp Glu Val Gly Ser 
145                 150                 155                 160 


Glu Glu Asp Leu Tyr Asp Asp Leu His Ser Ser Ser His His Tyr Ser 
                165                 170                 175     


His Pro Gly Gly Gly Gly Glu Gln Leu Ala Ile Asn Glu Leu Ile Ser 
            180                 185                 190         


Asp Gly Ser Val Val Cys Ala Glu Ala Leu Trp Asp His Val Xaa Met 
        195                 200                 205             


Asp Asp Gln Glu Leu Gly Phe Lys Ala Gly Asp Val Ile Glu Val Met 
    210                 215                 220                 


Asp Ala Xaa Asn Arg Glu Trp Trp Trp Gly Arg Val Ala Asp Gly Glu 
225                 230                 235                 240 


Gly Trp Phe Pro Ala Ser Phe Val Arg Leu Arg Val Asn Gln Asp Glu 
                245                 250                 255     


Pro Ala Asp Asp Asp Ala Pro Leu Ala Gly Asn Ser Gly Ala Glu Asp 
            260                 265                 270         


Gly Gly Ala Glu Ala Gln Ser Ser Lys Asp Gln Met Arg Xaa Asn Val 
        275                 280                 285             


Ile Asn Glu Ile Leu Ser Xaa Glu Arg Asp Tyr Ile Lys His Leu Arg 
    290                 295                 300                 


Asp Ile Cys Glu Gly Tyr Val Arg Gln Cys Arg Lys Arg Ala Asp Met 
305                 310                 315                 320 


Phe Ser Glu Glu Gln Leu Arg Xaa Ile Phe Gly Asn Ile Glu Asp Ile 
                325                 330                 335     


Tyr Arg Cys Gln Lys Ala Phe Val Lys Ala Leu Glu Gln Arg Phe Asn 
            340                 345                 350         


Arg Glu Arg Pro His Leu Ser Glu Leu Gly Ala Cys Phe Leu Glu His 
        355                 360                 365             


Gln Ala Asp Phe Gln Ile Tyr Ser Glu Tyr Cys Asn Asn His Pro Asn 
    370                 375                 380                 


Ala Cys Val Glu Leu Ser Arg Leu Xaa Lys Leu Ser Lys Tyr Val Tyr 
385                 390                 395                 400 


Phe Phe Glu Ala Cys Arg Leu Leu Gln Lys Met Ile Asp Ile Ser Leu 
                405                 410                 415     


Asp Gly Phe Leu Leu Xaa Pro Val Gln Lys Ile Cys Lys Tyr Pro Leu 
            420                 425                 430         


Gln Leu Ala Glu Leu Leu Lys Tyr Xaa His Pro Gln His Arg Asp Phe 
        435                 440                 445             


Lys Asp Val Glu Ala Ala Leu His Ala Met Lys Asn Val Ala Gln Leu 
    450                 455                 460                 


Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn Ile Asp Lys Ile Ala Gln 
465                 470                 475                 480 


Trp Gln Ser Ser Ile Glu Asp Trp Glu Gly Glu Asp Leu Leu Val Arg 
                485                 490                 495     


Ser Ser Glu Leu Ile Tyr Ser Gly Glu Leu Xaa Arg Val Xaa Gln Pro 
            500                 505                 510         


Gln Ala Lys Ser Gln Gln Arg Met Phe Phe Leu Phe Asp His Gln Leu 
        515                 520                 525             


Ile Tyr Cys Lys Lys Asp Leu Leu Arg Arg Asp Val Leu Tyr Tyr Lys 
    530                 535                 540                 


Gly Arg Leu Asp Met Asp Gly Leu Glu Val Val Asp Leu Glu Asp Gly 
545                 550                 555                 560 


Lys Asp Arg Asp Leu His Val Ser Ile Lys Asn Ala Phe Arg Leu His 
                565                 570                 575     


Arg Gly Ala Xaa Gly Asp Ser His Leu Leu Cys Xaa Arg Lys Pro Glu 
            580                 585                 590         


Gln Lys Gln Arg Trp Leu Lys Ala Phe Ala Arg Glu Arg Glu Gln Val 
        595                 600                 605             


Gln Leu Asp Gln Glu Xaa Gly Phe Ser Ile Xaa Glu Leu Gln Arg Lys 
    610                 615                 620                 


Gln Ala Met Leu Asn Ala Ser Lys Gln Gln Val Xaa Gly Lys Pro Lys 
625                 630                 635                 640 


Ala Val Gly Arg Pro Cys Tyr Leu Xaa Arg Gln Lys His Pro Ala Leu 
                645                 650                 655     


Pro Ser Asn Arg Pro Gln Gln Gln Val Leu Val Leu Ala Glu Pro Arg 
            660                 665                 670         


Arg Lys Pro Ser Xaa Phe Trp His Ser Ile Ser Arg Leu Ala Pro Phe 
        675                 680                 685             


Arg Lys 
    690 


<210> 3038
<211> 192
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<400> 3038
Met Pro Trp Glu Glu Pro Ala Gly Glu Lys Pro Ser Cys Ser His Ser 
1               5                   10                  15      


Gln Lys Ala Phe His Met Glu Pro Ala Gln Lys Pro Cys Phe Xaa Xaa 
            20                  25                  30          


Asp Met Val Xaa Trp Ala Leu Leu Cys Ile Ser Ala Glu Xaa Val Arg 
        35                  40                  45              


Gly Glu Ala Pro Ser Gln Pro Arg Gly Ile Pro His Arg Ser Pro Val 
    50                  55                  60                  


Ser Val Asp Asp Leu Trp Leu Glu Lys Xaa Gln Arg Lys Lys Leu Gln 
65                  70                  75                  80  


Lys Gln Ala His Val Glu Arg Arg Leu His Ile Gly Ala Val His Lys 
                85                  90                  95      


Asp Gly Val Lys Cys Trp Arg Lys Xaa Ile Ile Xaa Ser Pro Glu Ser 
            100                 105                 110         


Leu Asn Leu Pro Arg Arg Ser His Pro Leu Ser Gln Ser Ala Pro Xaa 
        115                 120                 125             


Gly Leu Asn His Met Gly Trp Pro Glu His Xaa Pro Gly Xaa Ala Val 
    130                 135                 140                 


Gly Arg Pro Cys Tyr Leu Xaa Arg Gln Lys His Pro Ala Leu Pro Ser 
145                 150                 155                 160 


Asn Arg Pro Gln Gln Gln Val Leu Val Leu Ala Glu Pro Arg Arg Lys 
                165                 170                 175     


Pro Ser Xaa Phe Trp His Ser Ile Ser Arg Leu Ala Pro Phe Arg Lys 
            180                 185                 190         


<210> 3039
<211> 517
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<400> 3039
Met Arg Gly Ala Val Ser Arg Ser Trp Ser Leu Glu Ser Leu Arg Ser 
1               5                   10                  15      


Ala Xaa Ala Ala Met Pro Asp Gly Ala Leu Asp Xaa Ala Val Cys Ala 
            20                  25                  30          


Asp Glu Val Gly Ser Glu Glu Asp Leu Tyr Asp Asp Leu His Ser Ser 
        35                  40                  45              


Ser His His Tyr Ser His Pro Gly Gly Gly Gly Glu Gln Leu Ala Ile 
    50                  55                  60                  


Asn Glu Leu Ile Ser Asp Gly Ser Val Val Cys Ala Glu Ala Leu Trp 
65                  70                  75                  80  


Asp His Val Xaa Met Asp Asp Gln Glu Leu Gly Phe Lys Ala Gly Asp 
                85                  90                  95      


Val Ile Glu Val Met Asp Ala Xaa Asn Arg Glu Trp Trp Trp Gly Arg 
            100                 105                 110         


Val Ala Asp Gly Glu Gly Trp Phe Pro Ala Ser Phe Val Arg Leu Arg 
        115                 120                 125             


Val Asn Gln Asp Glu Pro Ala Asp Asp Asp Ala Pro Leu Ala Gly Asn 
    130                 135                 140                 


Ser Gly Ala Glu Asp Gly Gly Ala Glu Ala Gln Ser Ser Lys Asp Gln 
145                 150                 155                 160 


Met Arg Xaa Asn Val Ile Asn Glu Ile Leu Ser Xaa Glu Arg Asp Tyr 
                165                 170                 175     


Ile Lys His Leu Arg Asp Ile Cys Glu Gly Tyr Val Arg Gln Cys Arg 
            180                 185                 190         


Lys Arg Ala Asp Met Phe Ser Glu Glu Gln Leu Arg Xaa Ile Phe Gly 
        195                 200                 205             


Asn Ile Glu Asp Ile Tyr Arg Cys Gln Lys Ala Phe Val Lys Ala Leu 
    210                 215                 220                 


Glu Gln Arg Phe Asn Arg Glu Arg Pro His Leu Ser Glu Leu Gly Ala 
225                 230                 235                 240 


Cys Phe Leu Glu His Gln Ala Asp Phe Gln Ile Tyr Ser Glu Tyr Cys 
                245                 250                 255     


Asn Asn His Pro Asn Ala Cys Val Glu Leu Ser Arg Leu Xaa Lys Leu 
            260                 265                 270         


Ser Lys Tyr Val Tyr Phe Phe Glu Ala Cys Arg Leu Leu Gln Lys Met 
        275                 280                 285             


Ile Asp Ile Ser Leu Asp Gly Phe Leu Leu Xaa Pro Val Gln Lys Ile 
    290                 295                 300                 


Cys Lys Tyr Pro Leu Gln Leu Ala Glu Leu Leu Lys Tyr Xaa His Pro 
305                 310                 315                 320 


Gln His Arg Asp Phe Lys Asp Val Glu Ala Ala Leu His Ala Met Lys 
                325                 330                 335     


Asn Val Ala Gln Leu Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn Ile 
            340                 345                 350         


Asp Lys Ile Ala Gln Trp Gln Ser Ser Ile Glu Asp Trp Glu Gly Glu 
        355                 360                 365             


Asp Leu Leu Val Arg Ser Ser Glu Leu Ile Tyr Ser Gly Glu Leu Xaa 
    370                 375                 380                 


Arg Val Xaa Gln Pro Gln Ala Lys Ser Gln Gln Arg Met Phe Phe Leu 
385                 390                 395                 400 


Phe Asp His Gln Leu Ile Tyr Cys Lys Lys Asp Leu Leu Arg Arg Asp 
                405                 410                 415     


Val Leu Tyr Tyr Lys Gly Arg Leu Asp Met Asp Gly Leu Glu Val Val 
            420                 425                 430         


Asp Leu Glu Asp Gly Lys Asp Arg Asp Leu His Val Ser Ile Lys Asn 
        435                 440                 445             


Ala Phe Arg Leu His Arg Gly Ala Xaa Gly Asp Ser His Leu Leu Cys 
    450                 455                 460                 


Xaa Arg Lys Pro Glu Gln Lys Gln Arg Trp Leu Lys Ala Phe Ala Arg 
465                 470                 475                 480 


Glu Arg Glu Gln Val Gln Leu Asp Gln Glu Xaa Gly Phe Ser Ile Xaa 
                485                 490                 495     


Glu Leu Gln Arg Lys Gln Ala Met Leu Asn Ala Ser Lys Gln Gln Val 
            500                 505                 510         


Xaa Gly Lys Pro Lys 
        515         


<210> 3040
<211> 619
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<400> 3040
Met Arg Pro Asp Gly Gln Gln Ala Leu Asp Ala Val Val Arg Ser Phe 
1               5                   10                  15      


Asp Cys His Ser Glu Ala Ala Leu Arg Gln Arg Asn Asp Val Ile Tyr 
            20                  25                  30          


Cys Ser Leu Pro Arg Xaa Ala Gln Gly Ile Val Gln Arg Glu Asp Gln 
        35                  40                  45              


Leu Glu Val Leu Val Ser Leu Arg Glu Val Trp Gly Arg Arg Arg Gly 
    50                  55                  60                  


Arg Asp Gly Xaa Cys Xaa Gly Ala Met Pro Asp Gly Ala Leu Asp Xaa 
65                  70                  75                  80  


Ala Val Cys Ala Asp Glu Val Gly Ser Glu Glu Asp Leu Tyr Asp Asp 
                85                  90                  95      


Leu His Ser Ser Ser His His Tyr Ser His Pro Gly Gly Gly Gly Glu 
            100                 105                 110         


Gln Leu Ala Ile Asn Glu Leu Ile Ser Asp Gly Ser Val Val Cys Ala 
        115                 120                 125             


Glu Ala Leu Trp Asp His Val Xaa Met Asp Asp Gln Glu Leu Gly Phe 
    130                 135                 140                 


Lys Ala Gly Asp Val Ile Glu Val Met Asp Ala Xaa Asn Arg Glu Trp 
145                 150                 155                 160 


Trp Trp Gly Arg Val Ala Asp Gly Glu Gly Trp Phe Pro Ala Ser Phe 
                165                 170                 175     


Val Arg Leu Arg Val Asn Gln Asp Glu Pro Ala Asp Asp Asp Ala Pro 
            180                 185                 190         


Leu Ala Gly Asn Ser Gly Ala Glu Asp Gly Gly Ala Glu Ala Gln Ser 
        195                 200                 205             


Ser Lys Asp Gln Met Arg Xaa Asn Val Ile Asn Glu Ile Leu Ser Xaa 
    210                 215                 220                 


Glu Arg Asp Tyr Ile Lys His Leu Arg Asp Ile Cys Glu Gly Tyr Val 
225                 230                 235                 240 


Arg Gln Cys Arg Lys Arg Ala Asp Met Phe Ser Glu Glu Gln Leu Arg 
                245                 250                 255     


Xaa Ile Phe Gly Asn Ile Glu Asp Ile Tyr Arg Cys Gln Lys Ala Phe 
            260                 265                 270         


Val Lys Ala Leu Glu Gln Arg Phe Asn Arg Glu Arg Pro His Leu Ser 
        275                 280                 285             


Glu Leu Gly Ala Cys Phe Leu Glu His Gln Ala Asp Phe Gln Ile Tyr 
    290                 295                 300                 


Ser Glu Tyr Cys Asn Asn His Pro Asn Ala Cys Val Glu Leu Ser Arg 
305                 310                 315                 320 


Leu Xaa Lys Leu Ser Lys Tyr Val Tyr Phe Phe Glu Ala Cys Arg Leu 
                325                 330                 335     


Leu Gln Lys Met Ile Asp Ile Ser Leu Asp Gly Phe Leu Leu Xaa Pro 
            340                 345                 350         


Val Gln Lys Ile Cys Lys Tyr Pro Leu Gln Leu Ala Glu Leu Leu Lys 
        355                 360                 365             


Tyr Xaa His Pro Gln His Arg Asp Phe Lys Asp Val Glu Ala Ala Leu 
    370                 375                 380                 


His Ala Met Lys Asn Val Ala Gln Leu Ile Asn Glu Arg Lys Arg Arg 
385                 390                 395                 400 


Leu Glu Asn Ile Asp Lys Ile Ala Gln Trp Gln Ser Ser Ile Glu Asp 
                405                 410                 415     


Trp Glu Gly Glu Asp Leu Leu Val Arg Ser Ser Glu Leu Ile Tyr Ser 
            420                 425                 430         


Gly Glu Leu Xaa Arg Val Xaa Gln Pro Gln Ala Lys Ser Gln Gln Arg 
        435                 440                 445             


Met Phe Phe Leu Phe Asp His Gln Leu Ile Tyr Cys Lys Lys Asp Leu 
    450                 455                 460                 


Leu Arg Arg Asp Val Leu Tyr Tyr Lys Gly Arg Leu Asp Met Asp Gly 
465                 470                 475                 480 


Leu Glu Val Val Asp Leu Glu Asp Gly Lys Asp Arg Asp Leu His Val 
                485                 490                 495     


Ser Ile Lys Asn Ala Phe Arg Leu His Arg Gly Ala Xaa Gly Asp Ser 
            500                 505                 510         


His Leu Leu Cys Xaa Arg Lys Pro Glu Gln Lys Gln Arg Trp Leu Lys 
        515                 520                 525             


Ala Phe Ala Arg Glu Arg Glu Gln Val Gln Leu Asp Gln Glu Xaa Gly 
    530                 535                 540                 


Phe Ser Ile Xaa Glu Leu Gln Arg Lys Gln Ala Met Leu Asn Ala Ser 
545                 550                 555                 560 


Lys Gln Gln Val Xaa Gly Lys Pro Lys Ala Val Gly Arg Pro Cys Tyr 
                565                 570                 575     


Leu Xaa Arg Gln Lys His Pro Ala Leu Pro Ser Asn Arg Pro Gln Gln 
            580                 585                 590         


Gln Val Leu Val Leu Ala Glu Pro Arg Arg Lys Pro Ser Xaa Phe Trp 
        595                 600                 605             


His Ser Ile Ser Arg Leu Ala Pro Phe Arg Lys 
    610                 615                 


<210> 3041
<211> 372
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<400> 3041
Pro Leu Ala Ser Xaa Pro Leu Ser Ser Ser Leu Val Ser Pro Glu His 
1               5                   10                  15      


Arg Arg Lys Ser Glu Pro Xaa Ile Lys Cys Xaa Ala Xaa Gln Glu Gly 
            20                  25                  30          


Gly Arg Tyr Leu Pro Ser Gly Ile Phe Pro Glu Lys Ser Trp Leu Ala 
        35                  40                  45              


Ser Pro Gly Ser Pro Arg Ala Gln Gln Ala Gly Ile Ala His Xaa Leu 
    50                  55                  60                  


Pro Ser Ser Ser Ala Cys Cys Leu Ala Tyr Glu Asn Pro Gly Xaa Pro 
65                  70                  75                  80  


Cys Arg Pro Xaa Ser Pro Lys Pro Leu Ser Pro Arg Pro Ser Ala Gln 
                85                  90                  95      


Arg Met Gly Leu His Tyr Pro Gly Arg Gly Ser Ala Ile Ser Met Val 
            100                 105                 110         


Ser Leu Gly Ser Tyr Ser Tyr Val Asp Ser Ser Ser Gly Asp Pro Glu 
        115                 120                 125             


Arg Pro Lys Ile Pro Lys Gly Gln Xaa Ser Phe Leu Leu Ser Leu Gln 
    130                 135                 140                 


Xaa Leu Asn Gln Asp Glu Gln Lys Glu Glu Ser Arg Glu Gly Gly Gln 
145                 150                 155                 160 


Gly Pro Arg Gly Leu Gly Xaa Val Pro Trp Leu Arg Asp Leu Pro Gly 
                165                 170                 175     


Ser Glu Asn His Met Pro Trp Glu Glu Pro Ala Gly Glu Lys Pro Ser 
            180                 185                 190         


Cys Ser His Ser Gln Lys Ala Phe His Met Glu Pro Ala Gln Lys Pro 
        195                 200                 205             


Cys Phe Xaa Xaa Asp Met Val Xaa Trp Ala Leu Leu Cys Ile Ser Ala 
    210                 215                 220                 


Glu Xaa Val Arg Gly Glu Ala Pro Ser Gln Pro Arg Gly Ile Pro His 
225                 230                 235                 240 


Arg Ser Pro Val Ser Val Asp Asp Leu Trp Leu Glu Lys Xaa Gln Arg 
                245                 250                 255     


Lys Lys Leu Gln Lys Gln Ala His Val Glu Arg Arg Leu His Ile Gly 
            260                 265                 270         


Ala Val His Lys Asp Gly Val Lys Cys Trp Arg Lys Xaa Ile Ile Xaa 
        275                 280                 285             


Ser Pro Glu Ser Leu Asn Leu Pro Arg Arg Ser His Pro Leu Ser Gln 
    290                 295                 300                 


Ser Ala Pro Xaa Gly Leu Asn His Met Gly Trp Pro Glu His Xaa Pro 
305                 310                 315                 320 


Gly Xaa Ala Val Gly Arg Pro Cys Tyr Leu Xaa Arg Gln Lys His Pro 
                325                 330                 335     


Ala Leu Pro Ser Asn Arg Pro Gln Gln Gln Val Leu Val Leu Ala Glu 
            340                 345                 350         


Pro Arg Arg Lys Pro Ser Xaa Phe Trp His Ser Ile Ser Arg Leu Ala 
        355                 360                 365             


Pro Phe Arg Lys 
    370         


<210> 3042
<211> 287
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<400> 3042
Xaa Ala Cys Val Glu Leu Ser Arg Leu Xaa Lys Leu Ser Lys Tyr Val 
1               5                   10                  15      


Tyr Phe Phe Glu Ala Cys Arg Leu Leu Gln Lys Met Ile Asp Ile Ser 
            20                  25                  30          


Leu Asp Gly Phe Leu Leu Xaa Pro Val Gln Lys Ile Cys Lys Tyr Pro 
        35                  40                  45              


Leu Gln Leu Ala Glu Leu Leu Lys Tyr Xaa His Pro Gln His Arg Asp 
    50                  55                  60                  


Phe Lys Asp Val Glu Ala Ala Leu His Ala Met Lys Asn Val Ala Gln 
65                  70                  75                  80  


Leu Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn Ile Asp Lys Ile Ala 
                85                  90                  95      


Gln Trp Gln Ser Ser Ile Glu Asp Trp Glu Gly Glu Asp Leu Leu Val 
            100                 105                 110         


Arg Ser Ser Glu Leu Ile Tyr Ser Gly Glu Leu Xaa Arg Val Xaa Gln 
        115                 120                 125             


Pro Gln Ala Lys Ser Gln Gln Arg Met Phe Phe Leu Phe Asp His Gln 
    130                 135                 140                 


Leu Ile Tyr Cys Lys Lys Asp Leu Leu Arg Arg Asp Val Leu Tyr Tyr 
145                 150                 155                 160 


Lys Gly Arg Leu Asp Met Asp Gly Leu Glu Val Val Asp Leu Glu Asp 
                165                 170                 175     


Gly Lys Asp Arg Asp Leu His Val Ser Ile Lys Asn Ala Phe Arg Leu 
            180                 185                 190         


His Arg Gly Ala Xaa Gly Asp Ser His Leu Leu Cys Xaa Arg Lys Pro 
        195                 200                 205             


Glu Gln Lys Gln Arg Trp Leu Lys Ala Phe Ala Arg Glu Arg Glu Gln 
    210                 215                 220                 


Val Gln Leu Asp Gln Glu Xaa Gly Phe Ser Ile Xaa Glu Leu Gln Arg 
225                 230                 235                 240 


Lys Gln Ala Met Leu Asn Ala Ser Lys Gln Gln Val Xaa Gly Lys Pro 
                245                 250                 255     


Lys Gly Arg Arg Xaa Ala Ala Pro Pro Pro Arg Leu Pro Gly Pro Tyr 
            260                 265                 270         


Pro Ala Asp Ile Ile Pro Phe Ser Glu Pro Gln Ser Gln Ala Ser 
        275                 280                 285         


<210> 3043
<211> 695
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<400> 3043
Xaa Glu Gly Gly Gln Gly Pro Arg Gly Leu Gly Xaa Val Pro Trp Leu 
1               5                   10                  15      


Arg Asp Leu Pro Gly Ser Glu Asn His Met Pro Trp Glu Glu Pro Ala 
            20                  25                  30          


Gly Glu Lys Pro Ser Cys Ser His Ser Gln Lys Ala Phe His Met Glu 
        35                  40                  45              


Pro Ala Gln Lys Pro Cys Phe Xaa Xaa Asp Met Val Xaa Trp Ala Leu 
    50                  55                  60                  


Leu Cys Ile Ser Ala Glu Xaa Val Arg Gly Glu Ala Pro Ser Gln Pro 
65                  70                  75                  80  


Arg Gly Ile Pro His Arg Ser Pro Val Ser Val Asp Asp Leu Trp Leu 
                85                  90                  95      


Glu Lys Xaa Gln Arg Lys Lys Leu Gln Lys Gln Ala His Val Glu Arg 
            100                 105                 110         


Arg Leu His Ile Gly Ala Val His Lys Asp Gly Val Lys Cys Trp Arg 
        115                 120                 125             


Lys Xaa Ile Ile Xaa Ser Pro Glu Ser Leu Asn Leu Pro Arg Arg Ser 
    130                 135                 140                 


His Pro Leu Ser Gln Ser Ala Pro Xaa Gly Leu Asn His Met Gly Trp 
145                 150                 155                 160 


Pro Glu His Xaa Pro Gly Xaa Ala Met Pro Asp Gly Ala Leu Asp Xaa 
                165                 170                 175     


Ala Val Cys Ala Asp Glu Val Gly Ser Glu Glu Asp Leu Tyr Asp Asp 
            180                 185                 190         


Leu His Ser Ser Ser His His Tyr Ser His Pro Gly Gly Gly Gly Glu 
        195                 200                 205             


Gln Leu Ala Ile Asn Glu Leu Ile Ser Asp Gly Ser Val Val Cys Ala 
    210                 215                 220                 


Glu Ala Leu Trp Asp His Val Xaa Met Asp Asp Gln Glu Leu Gly Phe 
225                 230                 235                 240 


Lys Ala Gly Asp Val Ile Glu Val Met Asp Ala Xaa Asn Arg Glu Trp 
                245                 250                 255     


Trp Trp Gly Arg Val Ala Asp Gly Glu Gly Trp Phe Pro Ala Ser Phe 
            260                 265                 270         


Val Arg Leu Arg Val Asn Gln Asp Glu Pro Ala Asp Asp Asp Ala Pro 
        275                 280                 285             


Leu Ala Gly Asn Ser Gly Ala Glu Asp Gly Gly Ala Glu Ala Gln Ser 
    290                 295                 300                 


Ser Lys Asp Gln Met Arg Xaa Asn Val Ile Asn Glu Ile Leu Ser Xaa 
305                 310                 315                 320 


Glu Arg Asp Tyr Ile Lys His Leu Arg Asp Ile Cys Glu Gly Tyr Val 
                325                 330                 335     


Arg Gln Cys Arg Lys Arg Ala Asp Met Phe Ser Glu Glu Gln Leu Arg 
            340                 345                 350         


Xaa Ile Phe Gly Asn Ile Glu Asp Ile Tyr Arg Cys Gln Lys Ala Phe 
        355                 360                 365             


Val Lys Ala Leu Glu Gln Arg Phe Asn Arg Glu Arg Pro His Leu Ser 
    370                 375                 380                 


Glu Leu Gly Ala Cys Phe Leu Glu His Gln Ala Asp Phe Gln Ile Tyr 
385                 390                 395                 400 


Ser Glu Tyr Cys Asn Asn His Pro Asn Ala Cys Val Glu Leu Ser Arg 
                405                 410                 415     


Leu Xaa Lys Leu Ser Lys Tyr Val Tyr Phe Phe Glu Ala Cys Arg Leu 
            420                 425                 430         


Leu Gln Lys Met Ile Asp Ile Ser Leu Asp Gly Phe Leu Leu Xaa Pro 
        435                 440                 445             


Val Gln Lys Ile Cys Lys Tyr Pro Leu Gln Leu Ala Glu Leu Leu Lys 
    450                 455                 460                 


Tyr Xaa His Pro Gln His Arg Asp Phe Lys Asp Val Glu Ala Ala Leu 
465                 470                 475                 480 


His Ala Met Lys Asn Val Ala Gln Leu Ile Asn Glu Arg Lys Arg Arg 
                485                 490                 495     


Leu Glu Asn Ile Asp Lys Ile Ala Gln Trp Gln Ser Ser Ile Glu Asp 
            500                 505                 510         


Trp Glu Gly Glu Asp Leu Leu Val Arg Ser Ser Glu Leu Ile Tyr Ser 
        515                 520                 525             


Gly Glu Leu Xaa Arg Val Xaa Gln Pro Gln Ala Lys Ser Gln Gln Arg 
    530                 535                 540                 


Met Phe Phe Leu Phe Asp His Gln Leu Ile Tyr Cys Lys Lys Asp Leu 
545                 550                 555                 560 


Leu Arg Arg Asp Val Leu Tyr Tyr Lys Gly Arg Leu Asp Met Asp Gly 
                565                 570                 575     


Leu Glu Val Val Asp Leu Glu Asp Gly Lys Asp Arg Asp Leu His Val 
            580                 585                 590         


Ser Ile Lys Asn Ala Phe Arg Leu His Arg Gly Ala Xaa Gly Asp Ser 
        595                 600                 605             


His Leu Leu Cys Xaa Arg Lys Pro Glu Gln Lys Gln Arg Trp Leu Lys 
    610                 615                 620                 


Ala Phe Ala Arg Glu Arg Glu Gln Val Gln Leu Asp Gln Glu Xaa Gly 
625                 630                 635                 640 


Phe Ser Ile Xaa Glu Leu Gln Arg Lys Gln Ala Met Leu Asn Ala Ser 
                645                 650                 655     


Lys Gln Gln Val Xaa Gly Lys Pro Lys Gly Arg Arg Xaa Ala Ala Pro 
            660                 665                 670         


Pro Pro Arg Leu Pro Gly Pro Tyr Pro Ala Asp Ile Ile Pro Phe Ser 
        675                 680                 685             


Glu Pro Gln Ser Gln Ala Ser 
    690                 695 


<210> 3044
<211> 142
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<400> 3044
Xaa Lys Lys Leu Arg Ala Arg Leu Ala Leu Ala His Lys Xaa Phe Ser 
1               5                   10                  15      


Asn Phe Ile Glu Ser Ile Val Leu Glu Lys Glu Asn Xaa His Glu Arg 
            20                  25                  30          


Ser Pro Ser Ser Pro Lys Gly Glu Lys Glu Lys Ser Arg Leu Arg Gln 
        35                  40                  45              


Gly Ser Trp Arg Ala Phe Leu Lys Ser Lys Asp Ala Gly Ser Pro Lys 
    50                  55                  60                  


Lys Pro Xaa Leu Val Ser Leu Pro Leu Gly Pro Glu Val Leu Ser Pro 
65                  70                  75                  80  


Ala Glu Xaa Asp Ser His Cys Glu Glu Arg Ala Glu Asp Lys Glu Gly 
                85                  90                  95      


Tyr Val Phe Ser Asp His Trp Ala Pro Pro Leu Ala Ser Xaa Pro Leu 
            100                 105                 110         


Ser Ser Ser Leu Val Ser Pro Glu His Arg Arg Lys Ser Glu Pro Xaa 
        115                 120                 125             


Ile Lys Cys Xaa Ala Xaa Gln Glu Gly Asp Ala Lys Pro Arg 
    130                 135                 140         


<210> 3045
<211> 502
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<400> 3045
Met Glu Pro Glu Pro Val Glu Asp Cys Val Gln Ser Xaa Leu Ala Ala 
1               5                   10                  15      


Leu Tyr Pro Pro Phe Glu Ala Xaa Ala Pro Xaa Leu Leu Gly Gln Val 
            20                  25                  30          


Phe Gln Val Val Glu Arg Xaa Tyr Arg Glu Asp Ala Leu Arg Tyr Xaa 
        35                  40                  45              


Leu Asp Phe Leu Val Pro Ala Lys His Leu Leu Ala Lys Val Gln Gln 
    50                  55                  60                  


Glu Ala Cys Ala Gln Tyr Ser Gly Phe Leu Phe Phe His Glu Gly Trp 
65                  70                  75                  80  


Pro Leu Cys Leu His Glu Gln Val Val Val Gln Leu Ala Ala Leu Pro 
                85                  90                  95      


Trp Gln Leu Leu Arg Pro Gly Asp Phe Tyr Leu Gln Val Val Pro Ser 
            100                 105                 110         


Ala Ala Gln Ala Pro Arg Leu Ala Leu Lys Cys Leu Ala Pro Gly Gly 
        115                 120                 125             


Gly Arg Val Gln Glu Val Pro Val Pro Asn Glu Ala Cys Ala Tyr Leu 
    130                 135                 140                 


Phe Xaa Pro Glu Trp Leu Gln Gly Ile Asn Lys Asp Arg Pro Xaa Gly 
145                 150                 155                 160 


Arg Leu Ser Xaa Cys Leu Leu Ser Ala Pro Ser Gly Ile Gln Arg Leu 
                165                 170                 175     


Pro Trp Ala Glu Leu Ile Cys Pro Arg Phe Val His Lys Glu Gly Leu 
            180                 185                 190         


Met Val Gly His Gln Pro Ser Xaa Leu Pro Pro Glu Leu Pro Ser Gly 
        195                 200                 205             


Pro Pro Gly Leu Pro Ser Pro Pro Leu Pro Glu Glu Ala Leu Gly Xaa 
    210                 215                 220                 


Arg Ser Pro Gly Asp Gly His Asn Ala Pro Val Glu Gly Pro Glu Gly 
225                 230                 235                 240 


Glu Tyr Val Glu Leu Leu Glu Val Xaa Leu Pro Val Arg Gly Ser Pro 
                245                 250                 255     


Xaa Asp Ala Glu Gly Ser Pro Gly Leu Ser Arg Val Arg Xaa Val Pro 
            260                 265                 270         


Xaa Arg Lys Gly Ala Gly Gly Lys Gly Arg His Arg Arg His Arg Ala 
        275                 280                 285             


Trp Met His Gln Lys Gly Leu Gly Pro Arg Gly Gln Asp Gly Ala Arg 
    290                 295                 300                 


Pro Pro Gly Glu Gly Ser Ser Xaa Gly Ala Ser Pro Glu Ser Pro Pro 
305                 310                 315                 320 


Gly Ala Glu Ala Val Pro Glu Ala Ala Val Leu Glu Val Ser Glu Pro 
                325                 330                 335     


Pro Ala Glu Ala Val Gly Glu Ala Ser Gly Ser Cys Pro Leu Arg Pro 
            340                 345                 350         


Gly Glu Leu Arg Gly Gly Gly Gly Gly Gly Gln Gly Ala Glu Gly Pro 
        355                 360                 365             


Pro Gly Xaa Pro Arg Arg Xaa Gly Lys Gly Asn Arg Arg Lys Lys Arg 
    370                 375                 380                 


Ala Ala Gly Arg Gly Ala Leu Ser Arg Gly Gly Asp Ser Ala Pro Leu 
385                 390                 395                 400 


Ser Pro Gly Asp Lys Glu Asp Ala Ser His Gln Glu Ala Leu Gly Asn 
                405                 410                 415     


Leu Pro Ser Pro Arg His Xaa Gly Pro Glu Gly Pro Leu Ser Asp Xaa 
            420                 425                 430         


Pro Xaa Pro Pro Leu Glu Xaa Val Gln Glu Gly Lys Gly Asp Asn Ile 
        435                 440                 445             


Pro Glu Glu Ala Leu Ala Val Ser Val Ser Asp His Pro Asp Val Ala 
    450                 455                 460                 


Trp Asp Leu Met Ala Ser Gly Phe Leu Ile Leu Xaa Ala Trp Pro Phe 
465                 470                 475                 480 


Cys Val Phe Arg Arg Gly Gly Pro Glu Trp Ala Ser Ser Ala Asp His 
                485                 490                 495     


Tyr Pro Xaa Val Pro Ser 
            500         


<210> 3046
<211> 557
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<400> 3046
Met Glu Pro Glu Pro Val Glu Asp Cys Val Gln Ser Xaa Leu Ala Ala 
1               5                   10                  15      


Leu Tyr Pro Pro Phe Glu Ala Xaa Ala Pro Xaa Leu Leu Gly Gln Val 
            20                  25                  30          


Phe Gln Val Val Glu Arg Xaa Tyr Arg Glu Asp Ala Leu Arg Tyr Xaa 
        35                  40                  45              


Leu Asp Phe Leu Val Pro Ala Lys His Leu Leu Ala Lys Val Gln Gln 
    50                  55                  60                  


Glu Ala Cys Ala Gln Tyr Ser Gly Phe Leu Phe Phe His Glu Gly Trp 
65                  70                  75                  80  


Pro Leu Cys Leu His Glu Gln Val Val Val Gln Leu Ala Ala Leu Pro 
                85                  90                  95      


Trp Gln Leu Leu Arg Pro Gly Asp Phe Tyr Leu Gln Val Val Pro Ser 
            100                 105                 110         


Ala Ala Gln Ala Pro Arg Leu Ala Leu Lys Cys Leu Ala Pro Gly Gly 
        115                 120                 125             


Gly Arg Val Gln Glu Val Pro Val Pro Asn Glu Ala Cys Ala Tyr Leu 
    130                 135                 140                 


Phe Xaa Pro Glu Trp Leu Gln Gly Ile Asn Lys Asp Arg Pro Xaa Gly 
145                 150                 155                 160 


Arg Leu Ser Xaa Cys Leu Leu Ser Ala Pro Ser Gly Ile Gln Arg Leu 
                165                 170                 175     


Pro Trp Ala Glu Leu Ile Cys Pro Arg Phe Val His Lys Glu Gly Leu 
            180                 185                 190         


Met Val Gly His Gln Pro Ser Xaa Leu Pro Pro Glu Leu Pro Ser Gly 
        195                 200                 205             


Pro Pro Gly Leu Pro Ser Pro Pro Leu Pro Glu Glu Ala Leu Gly Xaa 
    210                 215                 220                 


Arg Ser Pro Gly Asp Gly His Asn Ala Pro Val Glu Gly Pro Glu Gly 
225                 230                 235                 240 


Glu Tyr Val Glu Leu Leu Glu Val Xaa Leu Pro Val Arg Gly Ser Pro 
                245                 250                 255     


Xaa Asp Ala Glu Gly Ser Pro Gly Leu Ser Arg Val Arg Xaa Val Pro 
            260                 265                 270         


Xaa Arg Lys Gly Ala Gly Gly Lys Gly Arg His Arg Arg His Arg Ala 
        275                 280                 285             


Trp Met His Gln Lys Gly Leu Gly Pro Arg Gly Gln Asp Gly Ala Arg 
    290                 295                 300                 


Pro Pro Gly Glu Gly Ser Ser Xaa Gly Ala Ser Pro Glu Ser Pro Pro 
305                 310                 315                 320 


Gly Ala Glu Ala Val Pro Glu Ala Ala Val Leu Glu Val Ser Glu Pro 
                325                 330                 335     


Pro Ala Glu Ala Val Gly Glu Ala Ser Gly Ser Cys Pro Leu Arg Pro 
            340                 345                 350         


Gly Glu Leu Arg Gly Gly Gly Gly Gly Gly Gln Gly Ala Glu Gly Pro 
        355                 360                 365             


Pro Gly Xaa Pro Arg Arg Xaa Gly Lys Gly Asn Arg Arg Lys Lys Arg 
    370                 375                 380                 


Ala Ala Gly Arg Gly Ala Leu Ser Arg Gly Gly Asp Ser Ala Pro Leu 
385                 390                 395                 400 


Ser Pro Gly Asp Lys Glu Asp Ala Ser His Gln Glu Ala Leu Gly Asn 
                405                 410                 415     


Leu Pro Ser Pro Ser Glu His Lys Leu Pro Glu Cys His Leu Val Lys 
            420                 425                 430         


Glu Glu Tyr Glu Gly Ser Gly Lys Pro Glu Ser Glu Pro Lys Glu Leu 
        435                 440                 445             


Lys Xaa Ala Gly Glu Lys Glu Pro Gln Leu Ser Glu Ala Cys Gly Pro 
    450                 455                 460                 


Xaa Glu Glu Gly Ala Gly Glu Arg Glu Leu Glu Gly Pro Gly Leu Leu 
465                 470                 475                 480 


Cys Met Ala Gly His Xaa Gly Pro Glu Gly Pro Leu Ser Asp Xaa Pro 
                485                 490                 495     


Xaa Pro Pro Leu Glu Xaa Val Gln Glu Gly Lys Gly Asp Asn Ile Pro 
            500                 505                 510         


Glu Glu Ala Leu Ala Val Ser Val Ser Asp His Pro Asp Val Ala Trp 
        515                 520                 525             


Asp Leu Met Ala Ser Gly Phe Leu Ile Leu Xaa Gly Gln Trp Ala Ser 
    530                 535                 540                 


Val Gly Glu Gly Lys Gln Asp Trp Glu Arg Glu Ala Ile 
545                 550                 555         


<210> 3047
<211> 620
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<400> 3047
Met Glu Pro Glu Pro Val Glu Asp Cys Val Gln Ser Xaa Leu Ala Ala 
1               5                   10                  15      


Leu Tyr Pro Pro Phe Glu Ala Xaa Ala Pro Xaa Leu Leu Gly Gln Val 
            20                  25                  30          


Phe Gln Val Val Glu Arg Xaa Tyr Arg Glu Asp Ala Leu Arg Tyr Xaa 
        35                  40                  45              


Leu Asp Phe Leu Val Pro Ala Lys His Leu Leu Ala Lys Val Gln Gln 
    50                  55                  60                  


Glu Ala Cys Ala Gln Tyr Ser Gly Phe Leu Phe Phe His Glu Gly Trp 
65                  70                  75                  80  


Pro Leu Cys Leu His Glu Gln Val Val Val Gln Leu Ala Ala Leu Pro 
                85                  90                  95      


Trp Gln Leu Leu Arg Pro Gly Asp Phe Tyr Leu Gln Val Val Pro Ser 
            100                 105                 110         


Ala Ala Gln Ala Pro Arg Leu Ala Leu Lys Cys Leu Ala Pro Gly Gly 
        115                 120                 125             


Gly Arg Val Gln Glu Val Pro Val Pro Asn Glu Ala Cys Ala Tyr Leu 
    130                 135                 140                 


Phe Xaa Pro Glu Trp Leu Gln Gly Ile Asn Lys Asp Arg Pro Xaa Gly 
145                 150                 155                 160 


Arg Leu Ser Xaa Cys Leu Leu Ser Ala Pro Ser Gly Ile Gln Arg Leu 
                165                 170                 175     


Pro Trp Ala Glu Leu Ile Cys Pro Arg Phe Val His Lys Glu Gly Leu 
            180                 185                 190         


Met Val Gly His Gln Pro Ser Xaa Leu Pro Pro Glu Leu Pro Ser Gly 
        195                 200                 205             


Pro Pro Gly Leu Pro Ser Pro Pro Leu Pro Glu Glu Ala Leu Gly Xaa 
    210                 215                 220                 


Arg Ser Pro Gly Asp Gly His Asn Ala Pro Val Glu Gly Pro Glu Gly 
225                 230                 235                 240 


Glu Tyr Val Glu Leu Leu Glu Val Xaa Leu Pro Val Arg Gly Ser Pro 
                245                 250                 255     


Xaa Asp Ala Glu Gly Ser Pro Gly Leu Ser Arg Val Arg Xaa Val Pro 
            260                 265                 270         


Xaa Arg Lys Gly Ala Gly Gly Lys Gly Arg His Arg Arg His Arg Ala 
        275                 280                 285             


Trp Met His Gln Lys Gly Leu Gly Pro Arg Gly Gln Asp Gly Ala Arg 
    290                 295                 300                 


Pro Pro Gly Glu Gly Ser Ser Xaa Gly Ala Ser Pro Glu Ser Pro Pro 
305                 310                 315                 320 


Gly Ala Glu Ala Val Pro Glu Ala Ala Val Leu Glu Val Ser Glu Pro 
                325                 330                 335     


Pro Ala Glu Ala Val Gly Glu Ala Ser Gly Ser Cys Pro Leu Arg Pro 
            340                 345                 350         


Gly Glu Leu Arg Gly Gly Gly Gly Gly Gly Gln Gly Ala Glu Gly Pro 
        355                 360                 365             


Pro Gly Xaa Pro Arg Arg Xaa Gly Lys Gly Asn Arg Arg Lys Lys Arg 
    370                 375                 380                 


Ala Ala Gly Arg Gly Ala Leu Ser Arg Gly Gly Asp Ser Ala Pro Leu 
385                 390                 395                 400 


Ser Pro Gly Asp Lys Glu Asp Ala Ser His Gln Glu Ala Leu Gly Asn 
                405                 410                 415     


Leu Pro Ser Pro Ser Glu His Lys Leu Pro Glu Cys His Leu Val Lys 
            420                 425                 430         


Glu Glu Tyr Glu Gly Ser Gly Lys Pro Glu Ser Glu Pro Lys Glu Leu 
        435                 440                 445             


Lys Xaa Ala Gly Glu Lys Glu Pro Gln Leu Ser Glu Ala Cys Gly Pro 
    450                 455                 460                 


Xaa Glu Glu Gly Ala Gly Glu Arg Glu Leu Glu Gly Pro Gly Leu Leu 
465                 470                 475                 480 


Cys Met Ala Gly His Xaa Gly Pro Glu Gly Pro Leu Ser Asp Xaa Pro 
                485                 490                 495     


Xaa Pro Pro Leu Glu Xaa Val Gln Glu Gly Lys Gly Asp Asn Ile Pro 
            500                 505                 510         


Glu Glu Ala Leu Ala Val Ser Val Ser Asp His Pro Asp Val Ala Trp 
        515                 520                 525             


Asp Leu Met Ala Ser Gly Phe Leu Ile Leu Xaa Gly Gly Val Asp Gln 
    530                 535                 540                 


Ser Gly Arg Ala Leu Leu Xaa Ile Xaa Pro Pro Cys Pro Pro Glu Glu 
545                 550                 555                 560 


Pro Pro Pro Ser Arg Asp Xaa Leu Asn Xaa Xaa Leu His Tyr Leu His 
                565                 570                 575     


Ser Leu Leu Arg Pro Asp Leu Gln Xaa Leu Gly Leu Ser Val Leu Leu 
            580                 585                 590         


Asp Leu Arg Gln Ala Pro Pro Leu Pro Pro Ala Leu Ile Pro Ala Leu 
        595                 600                 605             


Ser Gln Leu Gln Phe Arg Val Ile Leu Phe Cys Pro 
    610                 615                 620 


<210> 3048
<211> 1519
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1103)..(1103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1321)..(1321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1327)..(1327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1355)..(1355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1364)..(1364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1406)..(1406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1412)..(1412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1418)..(1418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1466)..(1466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1492)..(1492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1494)..(1494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1516)..(1517)
<223> Selenocysteine

<400> 3048
Met Glu Pro Glu Pro Val Glu Asp Cys Val Gln Ser Xaa Leu Ala Ala 
1               5                   10                  15      


Leu Tyr Pro Pro Phe Glu Ala Xaa Ala Pro Xaa Leu Leu Gly Gln Val 
            20                  25                  30          


Phe Gln Val Val Glu Arg Xaa Tyr Arg Glu Asp Ala Leu Arg Tyr Xaa 
        35                  40                  45              


Leu Asp Phe Leu Val Pro Ala Lys His Leu Leu Ala Lys Val Gln Gln 
    50                  55                  60                  


Glu Ala Cys Ala Gln Tyr Ser Gly Phe Leu Phe Phe His Glu Gly Trp 
65                  70                  75                  80  


Pro Leu Cys Leu His Glu Gln Val Val Val Gln Leu Ala Ala Leu Pro 
                85                  90                  95      


Trp Gln Leu Leu Arg Pro Gly Asp Phe Tyr Leu Gln Val Val Pro Ser 
            100                 105                 110         


Ala Ala Gln Ala Pro Arg Leu Ala Leu Lys Cys Leu Ala Pro Gly Gly 
        115                 120                 125             


Gly Arg Val Gln Glu Val Pro Val Pro Asn Glu Ala Cys Ala Tyr Leu 
    130                 135                 140                 


Phe Xaa Pro Glu Trp Leu Gln Gly Ile Asn Lys Asp Arg Pro Xaa Gly 
145                 150                 155                 160 


Arg Leu Ser Xaa Cys Leu Leu Ser Ala Pro Ser Gly Ile Gln Arg Leu 
                165                 170                 175     


Pro Trp Ala Glu Leu Ile Cys Pro Arg Phe Val His Lys Glu Gly Leu 
            180                 185                 190         


Met Val Gly His Gln Pro Ser Xaa Leu Pro Pro Glu Leu Pro Ser Gly 
        195                 200                 205             


Pro Pro Gly Leu Pro Ser Pro Pro Leu Pro Glu Glu Ala Leu Gly Xaa 
    210                 215                 220                 


Arg Ser Pro Gly Asp Gly His Asn Ala Pro Val Glu Gly Pro Glu Gly 
225                 230                 235                 240 


Glu Tyr Val Glu Leu Leu Glu Val Xaa Leu Pro Val Arg Gly Ser Pro 
                245                 250                 255     


Xaa Asp Ala Glu Gly Ser Pro Gly Leu Ser Arg Val Arg Xaa Val Pro 
            260                 265                 270         


Xaa Arg Lys Gly Ala Gly Gly Lys Gly Arg His Arg Arg His Arg Ala 
        275                 280                 285             


Trp Met His Gln Lys Gly Leu Gly Pro Arg Gly Gln Asp Gly Ala Arg 
    290                 295                 300                 


Pro Pro Gly Glu Gly Ser Ser Xaa Gly Ala Ser Pro Glu Ser Pro Pro 
305                 310                 315                 320 


Gly Ala Glu Ala Val Pro Glu Ala Ala Val Leu Glu Val Ser Glu Pro 
                325                 330                 335     


Pro Ala Glu Ala Val Gly Glu Ala Ser Gly Ser Cys Pro Leu Arg Pro 
            340                 345                 350         


Gly Glu Leu Arg Gly Gly Gly Gly Gly Gly Gln Gly Ala Glu Gly Pro 
        355                 360                 365             


Pro Gly Xaa Pro Arg Arg Xaa Gly Lys Gly Asn Arg Arg Lys Lys Arg 
    370                 375                 380                 


Ala Ala Gly Arg Gly Ala Leu Ser Arg Gly Gly Asp Ser Ala Pro Leu 
385                 390                 395                 400 


Ser Pro Gly Asp Lys Glu Asp Ala Ser His Gln Glu Ala Leu Gly Asn 
                405                 410                 415     


Leu Pro Ser Pro Ser Glu His Lys Leu Pro Glu Cys His Leu Val Lys 
            420                 425                 430         


Glu Glu Tyr Glu Gly Ser Gly Lys Pro Glu Ser Glu Pro Lys Glu Leu 
        435                 440                 445             


Lys Xaa Ala Gly Glu Lys Glu Pro Gln Leu Ser Glu Ala Cys Gly Pro 
    450                 455                 460                 


Xaa Glu Glu Gly Ala Gly Glu Arg Glu Leu Glu Gly Pro Gly Leu Leu 
465                 470                 475                 480 


Cys Met Ala Gly His Xaa Gly Pro Glu Gly Pro Leu Ser Asp Xaa Pro 
                485                 490                 495     


Xaa Pro Pro Leu Glu Xaa Val Gln Glu Gly Lys Gly Asp Asn Ile Pro 
            500                 505                 510         


Glu Glu Ala Leu Ala Val Ser Val Ser Asp His Pro Asp Val Ala Trp 
        515                 520                 525             


Asp Leu Met Ala Ser Gly Phe Leu Ile Leu Xaa Gly Gly Val Asp Gln 
    530                 535                 540                 


Ser Gly Arg Ala Leu Leu Xaa Ile Xaa Pro Pro Cys Pro Pro Glu Glu 
545                 550                 555                 560 


Pro Pro Pro Ser Arg Asp Xaa Leu Asn Xaa Xaa Leu His Tyr Leu His 
                565                 570                 575     


Ser Leu Leu Arg Pro Asp Leu Gln Xaa Leu Gly Leu Ser Val Leu Leu 
            580                 585                 590         


Asp Leu Arg Gln Ala Pro Pro Leu Pro Pro Ala Leu Ile Pro Ala Leu 
        595                 600                 605             


Ser Gln Leu Gln Asp Ser Gly Asp Pro Pro Leu Val Gln Arg Leu Leu 
    610                 615                 620                 


Ile Leu Ile His Asp Asp Leu Pro Xaa Glu Leu Cys Gly Phe Gln Gly 
625                 630                 635                 640 


Ala Glu Val Leu Ser Glu Asn Asp Leu Lys Arg Val Ala Lys Pro Glu 
                645                 650                 655     


Glu Leu Gln Trp Glu Leu Gly Gly His Arg Asp Pro Ser Pro Ser His 
            660                 665                 670         


Trp Val Glu Ile His Gln Glu Val Val Arg Leu Cys Arg Leu Cys Gln 
        675                 680                 685             


Gly Val Leu Gly Ser Val Arg Gln Ala Ile Glu Glu Leu Glu Gly Ala 
    690                 695                 700                 


Ala Glu Pro Glu Glu Glu Glu Ala Val Gly Met Pro Lys Pro Leu Gln 
705                 710                 715                 720 


Lys Val Leu Ala Asp Pro Arg Leu Xaa Ala Leu Gln Arg Asp Gly Gly 
                725                 730                 735     


Ala Ile Leu Met Arg Leu Arg Ser Xaa Pro Ser Ser Lys Leu Glu Gly 
            740                 745                 750         


Gln Gly Pro Ala Xaa Leu Tyr Gln Glu Val Asp Glu Ala Ile His Gln 
        755                 760                 765             


Leu Val Arg Leu Ser Asn Leu His Val Gln Gln Gln Glu Gln Arg Gln 
    770                 775                 780                 


Cys Leu Arg Arg Leu Gln Gln Val Leu Gln Trp Leu Ser Gly Pro Gly 
785                 790                 795                 800 


Glu Glu Gln Leu Ala Ser Phe Ala Met Pro Gly Asp Xaa Leu Ser Ala 
                805                 810                 815     


Leu Gln Glu Xaa Glu Leu Arg Phe Arg Ala Phe Ser Ala Glu Val Gln 
            820                 825                 830         


Glu Arg Leu Ala Gln Ala Arg Glu Ala Leu Ala Leu Glu Glu Asn Ala 
        835                 840                 845             


Xaa Ser Gln Lys Val Leu Asp Ile Phe Glu Gln Arg Leu Glu Gln Val 
    850                 855                 860                 


Glu Ser Gly Leu His Arg Ala Leu Arg Leu Gln Arg Phe Phe Gln Gln 
865                 870                 875                 880 


Ala His Glu Trp Val Asp Glu Gly Phe Ala Arg Leu Ala Gly Ala Gly 
                885                 890                 895     


Pro Gly Arg Glu Ala Val Leu Ala Ala Leu Ala Leu Arg Arg Ala Pro 
            900                 905                 910         


Glu Pro Ser Ala Gly Xaa Phe Gln Glu Met Arg Ala Leu Ala Leu Asp 
        915                 920                 925             


Leu Gly Ser Pro Ala Ala Leu Arg Glu Trp Gly Arg Cys Gln Ala Arg 
    930                 935                 940                 


Cys Gln Glu Leu Glu Arg Arg Ile Gln Gln His Val Gly Glu Glu Ala 
945                 950                 955                 960 


Ser Pro Arg Gly Tyr Arg Arg Arg Arg Ala Asp Gly Ala Ser Ser Gly 
                965                 970                 975     


Gly Ala Gln Trp Gly Pro Arg Ser Pro Ser Pro Ser Leu Ser Ser Leu 
            980                 985                 990         


Leu Leu Pro Ser Ser Pro Gly Pro  Arg Pro Ala Pro Ser  His Cys Ser 
        995                 1000                 1005             


Leu Ala  Pro Cys Gly Glu Asp  Tyr Glu Glu Glu Gly  Pro Glu Leu 
    1010                 1015                 1020             


Ala Pro  Glu Ala Glu Gly Arg  Pro Pro Arg Ala Val  Leu Ile Arg 
    1025                 1030                 1035             


Gly Leu  Glu Val Xaa Ser Xaa  Glu Val Val Asp Arg  Xaa Cys Ser 
    1040                 1045                 1050             


Pro Arg  Glu His Val Leu Leu  Gly Arg Ala Arg Gly  Pro Asp Gly 
    1055                 1060                 1065             


Pro Trp  Gly Val Gly Xaa Pro  Arg Met Glu Arg Lys  Arg Ser Ile 
    1070                 1075                 1080             


Ser Ala  Gln Gln Arg Leu Val  Ser Glu Leu Ile Ala  Cys Glu Gln 
    1085                 1090                 1095             


Asp Tyr  Val Ala Xaa Leu Ser  Glu Pro Val Pro Pro  Pro Gly Pro 
    1100                 1105                 1110             


Glu Leu  Xaa Pro Glu Leu Arg  Gly Xaa Trp Ala Ala  Ala Leu Ser 
    1115                 1120                 1125             


Ala Arg  Glu Arg Leu Arg Ser  Phe His Arg Xaa His  Phe Leu Arg 
    1130                 1135                 1140             


Glu Leu  Gln Gly Cys Ala Xaa  His Pro Leu Arg Ile  Gly Ala Cys 
    1145                 1150                 1155             


Phe Leu  Arg His Gly Asp Gln  Phe Ser Leu Tyr Ala  Gln Tyr Val 
    1160                 1165                 1170             


Lys His  Arg His Lys Leu Glu  Asn Gly Leu Ala Ala  Leu Ser Pro 
    1175                 1180                 1185             


Leu Ser  Lys Gly Ser Met Glu  Ala Gly Pro Tyr Leu  Pro Arg Ala 
    1190                 1195                 1200             


Leu Gln  Gln Pro Leu Glu Gln  Leu Xaa Arg Tyr Gly  Arg Leu Leu 
    1205                 1210                 1215             


Glu Glu  Leu Leu Arg Glu Ala  Gly Pro Glu Leu Ser  Ser Glu Cys 
    1220                 1225                 1230             


Arg Ala  Leu Gly Ala Ala Val  Gln Leu Leu Arg Glu  Gln Glu Ala 
    1235                 1240                 1245             


Arg Gly  Arg Asp Leu Leu Ala  Val Glu Ala Val Arg  Gly Cys Glu 
    1250                 1255                 1260             


Ile Asp  Leu Lys Glu Gln Gly  Gln Leu Leu His Arg  Asp Pro Phe 
    1265                 1270                 1275             


Xaa Val  Ile Cys Gly Arg Lys  Lys Cys Leu Arg His  Val Phe Leu 
    1280                 1285                 1290             


Phe Glu  His Leu Leu Leu Phe  Ser Lys Leu Lys Gly  Pro Glu Gly 
    1295                 1300                 1305             


Gly Ser  Glu Met Phe Val Tyr  Lys Gln Ala Phe Lys  Xaa Ala Asp 
    1310                 1315                 1320             


Met Gly  Leu Xaa Glu Asn Ile  Gly Asp Ser Gly Leu  Cys Phe Glu 
    1325                 1330                 1335             


Leu Trp  Phe Arg Arg Arg Arg  Ala Arg Glu Ala Tyr  Xaa Leu Gln 
    1340                 1345                 1350             


Ala Xaa  Ser Pro Glu Ile Lys  Leu Lys Trp Xaa Ser  Ser Ile Ala 
    1355                 1360                 1365             


Gln Leu  Leu Trp Arg Gln Ala  Ala His Asn Lys Glu  Leu Arg Val 
    1370                 1375                 1380             


Gln Gln  Met Val Ser Met Gly  Ile Gly Asn Lys Pro  Phe Leu Asp 
    1385                 1390                 1395             


Ile Lys  Ala Leu Gly Glu Arg  Xaa Leu Ser Ala Leu  Leu Xaa Gly 
    1400                 1405                 1410             


Arg Ala  Ala Arg Xaa Arg Ala  Ser Val Ala Val Ser  Ser Phe Glu 
    1415                 1420                 1425             


His Ala  Gly Pro Ser Leu Pro  Gly Leu Ser Pro Gly  Ala Cys Ser 
    1430                 1435                 1440             


Leu Pro  Ala Arg Val Glu Glu  Glu Ala Trp Asp Leu  Asp Val Lys 
    1445                 1450                 1455             


Gln Ile  Ser Leu Ala Pro Glu  Xaa Leu Asp Ser Ser  Gly Asp Val 
    1460                 1465                 1470             


Ser Pro  Gly Pro Arg Asn Ser  Pro Ser Leu Gln Pro  Pro His Pro 
    1475                 1480                 1485             


Gly Ser  Ser Xaa Pro Xaa Leu  Ala Ser Arg Gly Ile  Leu Gly Leu 
    1490                 1495                 1500             


Ser Arg  Gln Ser His Ala Arg  Ala Leu Ser Asp Pro  Xaa Xaa Pro 
    1505                 1510                 1515             


Leu 
    


<210> 3049
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<400> 3049
Met Glu Ala Glu Glu Ala Gln Arg Gly Ala Ser Pro Pro Ile Ser Ala 
1               5                   10                  15      


Ile Glu Glu Phe Ser Ile Ile Pro Glu Ala Pro Met Arg Ser Ser Gln 
            20                  25                  30          


Val Ser Ala Leu Gly Leu Glu Ala Gln Glu Asp Glu Asp Pro Ser Tyr 
        35                  40                  45              


Lys Trp Arg Glu Glu His Arg Leu Ser Ala Xaa Gln Gln Asn Ser Arg 
    50                  55                  60                  


Gly Pro Ala Val Glu Lys His Pro Gly Pro Ser Asp Xaa Val Val Phe 
65                  70                  75                  80  


Arg Glu Lys Lys Pro Lys Glu Val Met Gly Gly Phe Ser Arg Arg Cys 
                85                  90                  95      


Ser Lys Leu Ile Asn Ser Ser Gln Leu Leu Tyr Gln Glu Tyr Ser Asp 
            100                 105                 110         


Val Val Leu Asn Lys Glu Ile Gln Ser Gln Gln Arg Leu Glu Ser Leu 
        115                 120                 125             


Ser Glu Xaa Pro Gly Pro Ser Ser Pro Arg Gln Pro Arg Lys Ala Leu 
    130                 135                 140                 


Val Ser Ser Glu Ser Tyr Leu Gln Arg Leu Ser Met Ala Ser Ser Gly 
145                 150                 155                 160 


Ser Leu Trp Gln Glu Ile Pro Val Val Arg Asn Ser Xaa Val Leu Leu 
                165                 170                 175     


Ser Met Xaa His Glu 
            180     


<210> 3050
<211> 1597
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1272)..(1272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1277)..(1277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1342)..(1342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1365)..(1365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1398)..(1398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1484)..(1484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1486)..(1486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1540)..(1540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1587)..(1587)
<223> Selenocysteine

<400> 3050
Met Glu Ala Glu Glu Ala Gln Arg Gly Ala Ser Pro Pro Ile Ser Ala 
1               5                   10                  15      


Ile Glu Glu Phe Ser Ile Ile Pro Glu Ala Pro Met Arg Ser Ser Gln 
            20                  25                  30          


Val Ser Ala Leu Gly Leu Glu Ala Gln Glu Asp Glu Asp Pro Ser Tyr 
        35                  40                  45              


Lys Trp Arg Glu Glu His Arg Leu Ser Ala Xaa Gln Gln Ser Glu Leu 
    50                  55                  60                  


Arg Asp Val Cys Asp Tyr Ala Ile Glu Xaa Met Pro Ser Phe Pro Lys 
65                  70                  75                  80  


Glu Gly Ser Ala Asp Val Glu Pro Asn Gln Glu Ser Leu Val Ala Glu 
                85                  90                  95      


Ala Cys Asp Xaa Pro Glu His Trp Glu Ala Val Pro Gln Ser Leu Ala 
            100                 105                 110         


Gly Arg Gln Ala Arg Xaa Leu Ala Pro Pro Glu Leu Trp Ala Cys Pro 
        115                 120                 125             


Ile Gln Ser Glu His Leu Asp Met Ala Pro Phe Ser Ser Asp Leu Gly 
    130                 135                 140                 


Ser Glu Glu Glu Glu Val Glu Phe Trp Pro Gly Leu Xaa Ser Leu Xaa 
145                 150                 155                 160 


Leu Gly Ser Gly Gln Ala Glu Glu Glu Glu Glu Xaa Ser Ser Asp Asn 
                165                 170                 175     


Ser Gly Gln Xaa Arg Tyr Tyr Ser Pro Cys Glu Glu His Pro Ala Glu 
            180                 185                 190         


Xaa Asn Gln Asn Glu Gly Ser Glu Ser Gly Xaa Ile Arg Gln Gly Glu 
        195                 200                 205             


Glu Leu Pro Pro Glu Glu Leu Gln Glu Ser Gln Gly Leu Leu His Pro 
    210                 215                 220                 


Gln Glu Val Gln Val Leu Glu Glu Gln Gly Gln Gln Glu Ala Gly Phe 
225                 230                 235                 240 


Arg Gly Glu Gly Xaa Leu Arg Glu Asp Val Cys Ala Asp Gly Leu Leu 
                245                 250                 255     


Gly Glu Glu Gln Met Ile Glu Gln Val Asn Asp Glu Lys Gly Glu Gln 
            260                 265                 270         


Lys Gln Lys Gln Glu Gln Val Gln Asp Val Met Leu Gly Arg Gln Gly 
        275                 280                 285             


Glu Arg Met Gly Leu Xaa Gly Glu Pro Glu Gly Leu Asn Asp Gly Glu 
    290                 295                 300                 


Trp Glu Gln Glu Asp Met Glu Arg Lys Ala Gln Gly Gln Gly Gly Pro 
305                 310                 315                 320 


Glu Gln Gly Glu Glu Arg Lys Arg Glu Leu Gln Val Pro Glu Glu Asn 
                325                 330                 335     


Arg Ala Asp Ser Gln Asp Glu Lys Ser Gln Xaa Phe Leu Gly Lys Ser 
            340                 345                 350         


Glu Glu Val Xaa Gly Lys Gln Glu Asp His Gly Ile Lys Glu Lys Gly 
        355                 360                 365             


Val Pro Val Ser Gly Gln Glu Ala Lys Glu Pro Glu Ser Trp Asp Gly 
    370                 375                 380                 


Gly Arg Leu Gly Ala Val Gly Arg Ala Arg Ser Arg Glu Glu Glu Asn 
385                 390                 395                 400 


Glu His His Gly Pro Ser Met Pro Ala Leu Ile Ala Pro Glu Asp Ser 
                405                 410                 415     


Pro His Cys Asp Leu Phe Pro Gly Ala Ser Tyr Leu Met Xaa Gln Ile 
            420                 425                 430         


Pro Gly Xaa Gln Xaa Glu Ser Arg Ala Glu Glu Leu Ser Pro Ala Ala 
        435                 440                 445             


Leu Ser Pro Ser Leu Glu Pro Ile Arg Cys Ser His Gln Pro Ile Ser 
    450                 455                 460                 


Leu Leu Gly Ser Phe Leu Xaa Glu Glu Ser Pro Asp Lys Glu Ile Asp 
465                 470                 475                 480 


Gln Asn Ser Gln Gln Glu Glu Ser Arg Leu Arg Lys Gly Xaa Val Ser 
                485                 490                 495     


Ser Gln Gly Xaa Glu Val Val Phe Ala Ser Ala Ser Val Xaa Pro Pro 
            500                 505                 510         


Arg Xaa Pro Asp Ser Ala Pro Pro Ser Pro Ala Glu Ala Tyr Pro Ile 
        515                 520                 525             


Xaa Pro Ala Ser Val Ser Ala Arg Pro Pro Val Ala Phe Pro Arg Arg 
    530                 535                 540                 


Glu Xaa Ser Cys Ala Ala Arg Ala Pro Glu Xaa Ala Ser Ala Pro Leu 
545                 550                 555                 560 


Ser Met Asp Asp Pro Ser Pro Cys Gly Xaa Ser Glu Met Cys Pro Ala 
                565                 570                 575     


Ala Leu Tyr Gly Phe Pro Ser Xaa Gly Xaa Ser Pro Pro Arg Pro Pro 
            580                 585                 590         


Ala Asn Ser Xaa Gly Xaa Val Gln His Leu Arg Ser Asp Ser Phe Pro 
        595                 600                 605             


Gly Ser His Arg Xaa Glu Gln Xaa Pro Asp Leu Val Gly Met Leu Leu 
    610                 615                 620                 


Ser Tyr Ser His Ser Glu Leu Pro Gln Arg Pro Pro Lys Pro Ala Ile 
625                 630                 635                 640 


Tyr Ser Ser Val Xaa Pro Arg Arg Asp Arg Arg Ser Gly Arg Asp Tyr 
                645                 650                 655     


Ser Xaa Val Ser Ala Ser Pro Xaa Ala Leu Ser Xaa Leu Lys Gln Asp 
            660                 665                 670         


Ser Gln Glu Ser Ile Ser Asn Leu Glu Arg Pro Ser Ser Pro Pro Ser 
        675                 680                 685             


Ile Gln Pro Trp Val Ser Pro His Asn Pro Ala Phe Ala Xaa Glu Ser 
    690                 695                 700                 


Pro Ala Tyr Gly Ser Ser Pro Ser Phe Val Ser Met Glu Asp Val Arg 
705                 710                 715                 720 


Ile His Glu Pro Leu Pro Pro Pro Pro Pro Gln Arg Arg Asp Xaa His 
                725                 730                 735     


Pro Ser Val Val Glu Xaa Asp Gly His Ala Arg Val Val Val Pro Xaa 
            740                 745                 750         


Leu Lys Gln His Ser His Pro Pro Pro Leu Ala Leu Gly Ser Gly Leu 
        755                 760                 765             


His Ala Pro His Lys Gly Pro Leu Pro Gln Ala Ser Asp Pro Ala Val 
    770                 775                 780                 


Ala Arg Gln His Arg Pro Leu Pro Ser Xaa Pro Asp Ser Ser His His 
785                 790                 795                 800 


Ala Gln Ala Xaa Pro Arg Trp Arg Tyr Asn Lys Pro Leu Pro Pro Xaa 
                805                 810                 815     


Pro Asp Leu Pro Gln Pro His Leu Pro Pro Ile Ser Ala Pro Gly Ser 
            820                 825                 830         


Ser Arg Ile Tyr Arg Pro Leu Pro Pro Leu Pro Ile Ile Asp Pro Pro 
        835                 840                 845             


Xaa Glu Pro Pro Pro Leu Pro Pro Lys Ser Arg Gly Arg Ser Arg Ser 
    850                 855                 860                 


Xaa Arg Gly Gly His Met Asn Ser Gly Gly His Ala Lys Xaa Arg Pro 
865                 870                 875                 880 


Ala Cys Gln Asp Trp Xaa Val Pro Leu Pro Ala Ser Ala Gly Arg Xaa 
                885                 890                 895     


Ser Trp Pro Pro Ala Xaa Ala Arg Ser Xaa Glu Ser Phe Xaa Ser Xaa 
            900                 905                 910         


Ser Arg Ser Lys Ser Glu Val Ser Pro Gly Met Ala Phe Ser Asn Met 
        915                 920                 925             


Xaa Asn Phe Leu Cys Pro Ser Ser Pro Xaa Xaa Pro Trp Xaa Pro Glu 
    930                 935                 940                 


Leu Gln Gly Pro Xaa Ser Lys Asp Glu Ala Gly Val Ser Glu His Pro 
945                 950                 955                 960 


Glu Ala Pro Ala Arg Glu Pro Leu Arg Arg Xaa Xaa Pro Gln Gln Gly 
                965                 970                 975     


Ala Ser Gly Pro Gly Arg Ser Pro Val Gly Gln Ala Arg Gln Pro Glu 
            980                 985                 990         


Lys Pro Ser His Leu His Leu Glu  Lys Ala Ser Ser Trp  Pro His Arg 
        995                 1000                 1005             


Arg Asp  Ser Gly Arg Pro Pro  Gly Asp Ser Ser Gly  Gln Ala Val 
    1010                 1015                 1020             


Ala Pro  Ser Glu Gly Ala Asn  Lys His Lys Gly Trp  Ser Arg Gln 
    1025                 1030                 1035             


Gly Leu  Arg Arg Pro Ser Ile  Leu Pro Glu Gly Ser  Ser Asp Ser 
    1040                 1045                 1050             


Arg Gly  Pro Ala Val Glu Lys  His Pro Gly Pro Ser  Asp Xaa Val 
    1055                 1060                 1065             


Val Phe  Arg Glu Lys Lys Pro  Lys Glu Val Met Gly  Gly Phe Ser 
    1070                 1075                 1080             


Arg Arg  Cys Ser Lys Leu Ile  Asn Ser Ser Gln Leu  Leu Tyr Gln 
    1085                 1090                 1095             


Glu Tyr  Ser Asp Val Val Leu  Asn Lys Glu Ile Gln  Ser Gln Gln 
    1100                 1105                 1110             


Arg Leu  Glu Ser Leu Ser Glu  Xaa Pro Gly Pro Ser  Ser Pro Arg 
    1115                 1120                 1125             


Gln Pro  Arg Lys Ala Leu Val  Ser Ser Glu Ser Tyr  Leu Gln Arg 
    1130                 1135                 1140             


Leu Ser  Met Ala Ser Ser Gly  Ser Leu Trp Gln Glu  Ile Pro Val 
    1145                 1150                 1155             


Val Arg  Asn Ser Xaa Val Leu  Leu Ser Met Xaa His  Glu Asp Gln 
    1160                 1165                 1170             


Lys Leu  Gln Glu Val Lys Phe  Glu Leu Ile Val Ser  Glu Ala Ser 
    1175                 1180                 1185             


Tyr Leu  Arg Ser Leu Asn Ile  Ala Val Asp His Phe  Gln Leu Ser 
    1190                 1195                 1200             


Xaa Ser  Leu Arg Ala Xaa Leu  Ser Asn Gln Glu His  Gln Trp Leu 
    1205                 1210                 1215             


Phe Ser  Arg Leu Gln Asp Val  Arg Asp Val Ser Ala  Xaa Phe Leu 
    1220                 1225                 1230             


Ser Asp  Leu Glu Glu Asn Phe  Glu Asn Asn Ile Phe  Ser Phe Gln 
    1235                 1240                 1245             


Val Cys  Asp Val Val Leu Asn  His Ala Pro Asp Phe  Arg Arg Val 
    1250                 1255                 1260             


Tyr Leu  Pro Tyr Val Xaa Asn  Gln Xaa Tyr Gln Glu  Arg Xaa Phe 
    1265                 1270                 1275             


Gln Ser  Leu Met Asn Ser Asn  Ser Asn Phe Arg Glu  Val Leu Glu 
    1280                 1285                 1290             


Lys Leu  Glu Ser Asp Pro Val  Cys Gln Arg Leu Ser  Leu Lys Ser 
    1295                 1300                 1305             


Phe Leu  Ile Leu Pro Phe Gln  Arg Ile Xaa Arg Leu  Lys Leu Leu 
    1310                 1315                 1320             


Leu Gln  Asn Ile Leu Lys Arg  Xaa Gln Pro Gly Ser  Ser Glu Glu 
    1325                 1330                 1335             


Ala Glu  Ala Xaa Lys Ala His  His Ala Leu Glu Gln  Leu Ile Arg 
    1340                 1345                 1350             


Asp Cys  Asn Asn Asn Val Gln  Ser Met Arg Arg Xaa  Glu Glu Leu 
    1355                 1360                 1365             


Ile Tyr  Leu Ser Gln Lys Ile  Glu Phe Glu Cys Lys  Ile Phe Pro 
    1370                 1375                 1380             


Leu Ile  Ser Gln Ser Arg Trp  Leu Val Lys Ser Gly  Glu Leu Xaa 
    1385                 1390                 1395             


Ala Leu  Glu Phe Ser Ala Ser  Pro Gly Leu Arg Arg  Lys Leu Asn 
    1400                 1405                 1410             


Xaa Arg  Pro Val His Leu His  Leu Phe Asn Asp Cys  Leu Leu Leu 
    1415                 1420                 1425             


Ser Arg  Pro Arg Glu Gly Ser  Arg Phe Leu Val Phe  Asp His Ala 
    1430                 1435                 1440             


Pro Phe  Ser Ser Ile Arg Gly  Glu Lys Cys Glu Met  Lys Leu His 
    1445                 1450                 1455             


Gly Pro  His Lys Asn Leu Phe  Arg Leu Phe Leu Arg  Gln Asn Xaa 
    1460                 1465                 1470             


Gln Gly  Ala Gln Ala Glu Phe  Leu Phe Arg Xaa Glu  Xaa Gln Ser 
    1475                 1480                 1485             


Glu Lys  Leu Arg Trp Ile Ser  Ala Leu Ala Met Pro  Arg Glu Glu 
    1490                 1495                 1500             


Leu Asp  Leu Leu Glu Cys Tyr  Asn Ser Pro Gln Val  Gln Cys Leu 
    1505                 1510                 1515             


Arg Ala  Tyr Lys Pro Arg Glu  Asn Asp Glu Leu Ala  Leu Glu Lys 
    1520                 1525                 1530             


Ala Asp  Val Val Met Val Xaa  Gln Gln Ser Ser Asp  Gly Trp Leu 
    1535                 1540                 1545             


Glu Gly  Val Arg Leu Ser Asp  Gly Glu Arg Gly Trp  Phe Pro Val 
    1550                 1555                 1560             


Gln Gln  Val Glu Phe Ile Ser  Asn Pro Glu Val Arg  Ala Gln Asn 
    1565                 1570                 1575             


Leu Lys  Glu Ala His Arg Val  Lys Xaa Ala Lys Leu  Gln Leu Val 
    1580                 1585                 1590             


Glu Gln  Gln Ala 
    1595         


<210> 3051
<211> 519
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<400> 3051
Met Gly Gly Phe Ser Arg Arg Cys Ser Lys Leu Ile Asn Ser Ser Gln 
1               5                   10                  15      


Leu Leu Tyr Gln Glu Tyr Ser Asp Val Val Leu Asn Lys Glu Ile Gln 
            20                  25                  30          


Ser Gln Gln Arg Leu Glu Ser Leu Ser Glu Xaa Pro Gly Pro Ser Ser 
        35                  40                  45              


Pro Arg Gln Pro Arg Lys Ala Leu Val Ser Ser Glu Ser Tyr Leu Gln 
    50                  55                  60                  


Arg Leu Ser Met Ala Ser Ser Gly Ser Leu Trp Gln Glu Ile Pro Val 
65                  70                  75                  80  


Val Arg Asn Ser Xaa Val Leu Leu Ser Met Xaa His Glu Asp Gln Lys 
                85                  90                  95      


Leu Gln Glu Val Lys Phe Glu Leu Ile Val Ser Glu Ala Ser Tyr Leu 
            100                 105                 110         


Arg Ser Leu Asn Ile Ala Val Asp His Phe Gln Leu Ser Xaa Ser Leu 
        115                 120                 125             


Arg Ala Xaa Leu Ser Asn Gln Glu His Gln Trp Leu Phe Ser Arg Leu 
    130                 135                 140                 


Gln Asp Val Arg Asp Val Ser Ala Xaa Phe Leu Ser Asp Leu Glu Glu 
145                 150                 155                 160 


Asn Phe Glu Asn Asn Ile Phe Ser Phe Gln Val Cys Asp Val Val Leu 
                165                 170                 175     


Asn His Ala Pro Asp Phe Arg Arg Val Tyr Leu Pro Tyr Val Xaa Asn 
            180                 185                 190         


Gln Xaa Tyr Gln Glu Arg Xaa Phe Gln Ser Leu Met Asn Ser Asn Ser 
        195                 200                 205             


Asn Phe Arg Glu Val Leu Glu Lys Leu Glu Ser Asp Pro Val Cys Gln 
    210                 215                 220                 


Arg Leu Ser Leu Lys Ser Phe Leu Ile Leu Pro Phe Gln Arg Ile Xaa 
225                 230                 235                 240 


Arg Leu Lys Leu Leu Leu Gln Asn Ile Leu Lys Arg Xaa Gln Pro Gly 
                245                 250                 255     


Ser Ser Glu Glu Ala Glu Ala Xaa Lys Ala His His Ala Leu Glu Gln 
            260                 265                 270         


Leu Ile Arg Asp Cys Asn Asn Asn Val Gln Ser Met Arg Arg Xaa Glu 
        275                 280                 285             


Glu Leu Ile Tyr Leu Ser Gln Lys Ile Glu Phe Glu Cys Lys Ile Phe 
    290                 295                 300                 


Pro Leu Ile Ser Gln Ser Arg Trp Leu Val Lys Ser Gly Glu Leu Xaa 
305                 310                 315                 320 


Ala Leu Glu Phe Ser Ala Ser Pro Gly Leu Arg Arg Lys Leu Asn Xaa 
                325                 330                 335     


Arg Pro Val His Leu His Leu Phe Asn Asp Cys Leu Leu Leu Ser Arg 
            340                 345                 350         


Pro Arg Glu Gly Ser Arg Phe Leu Val Phe Asp His Ala Pro Phe Ser 
        355                 360                 365             


Ser Ile Arg Gly Glu Lys Cys Glu Met Lys Leu His Gly Pro His Lys 
    370                 375                 380                 


Asn Leu Phe Arg Leu Phe Leu Arg Gln Asn Xaa Gln Gly Ala Gln Ala 
385                 390                 395                 400 


Glu Phe Leu Phe Arg Xaa Glu Xaa Gln Ser Glu Lys Leu Arg Trp Ile 
                405                 410                 415     


Ser Ala Leu Ala Met Pro Arg Glu Glu Leu Asp Leu Leu Glu Cys Tyr 
            420                 425                 430         


Asn Ser Pro Gln Val Gln Cys Leu Arg Ala Tyr Lys Pro Arg Glu Asn 
        435                 440                 445             


Asp Glu Leu Ala Leu Glu Lys Ala Asp Val Val Met Val Xaa Gln Gln 
    450                 455                 460                 


Ser Ser Asp Gly Trp Leu Glu Gly Val Arg Leu Ser Asp Gly Glu Arg 
465                 470                 475                 480 


Gly Trp Phe Pro Val Gln Gln Val Glu Phe Ile Ser Asn Pro Glu Val 
                485                 490                 495     


Arg Ala Gln Asn Leu Lys Glu Ala His Arg Val Lys Xaa Ala Lys Leu 
            500                 505                 510         


Gln Leu Val Glu Gln Gln Ala 
        515                 


<210> 3052
<211> 797
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<400> 3052
Xaa Val Val Val Pro Xaa Leu Lys Gln His Ser His Pro Pro Pro Leu 
1               5                   10                  15      


Ala Leu Gly Ser Gly Leu His Ala Pro His Lys Gly Pro Leu Pro Gln 
            20                  25                  30          


Ala Ser Asp Pro Ala Val Ala Arg Gln His Arg Pro Leu Pro Ser Xaa 
        35                  40                  45              


Pro Asp Ser Ser His His Ala Gln Ala Xaa Pro Arg Trp Arg Tyr Asn 
    50                  55                  60                  


Lys Pro Leu Pro Pro Xaa Pro Asp Leu Pro Gln Pro His Leu Pro Pro 
65                  70                  75                  80  


Ile Ser Ala Pro Gly Ser Ser Arg Ile Tyr Arg Pro Leu Pro Pro Leu 
                85                  90                  95      


Pro Ile Ile Asp Pro Pro Xaa Glu Pro Pro Pro Leu Pro Pro Lys Ser 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Xaa Arg Gly Gly His Met Asn Ser Gly Gly 
        115                 120                 125             


His Ala Lys Xaa Arg Pro Ala Cys Gln Asp Trp Xaa Val Pro Leu Pro 
    130                 135                 140                 


Ala Ser Ala Gly Arg Xaa Ser Trp Pro Pro Ala Xaa Ala Arg Ser Xaa 
145                 150                 155                 160 


Glu Ser Phe Xaa Ser Xaa Ser Arg Ser Lys Ser Glu Val Ser Pro Gly 
                165                 170                 175     


Met Ala Phe Ser Asn Met Xaa Asn Phe Leu Cys Pro Ser Ser Pro Xaa 
            180                 185                 190         


Xaa Pro Trp Xaa Pro Glu Leu Gln Gly Pro Xaa Ser Lys Asp Glu Ala 
        195                 200                 205             


Gly Val Ser Glu His Pro Glu Ala Pro Ala Arg Glu Pro Leu Arg Arg 
    210                 215                 220                 


Xaa Xaa Pro Gln Gln Gly Ala Ser Gly Pro Gly Arg Ser Pro Val Gly 
225                 230                 235                 240 


Gln Ala Arg Gln Pro Glu Lys Pro Ser His Leu His Leu Glu Lys Ala 
                245                 250                 255     


Ser Ser Trp Pro His Arg Arg Asp Ser Gly Arg Pro Pro Gly Asp Ser 
            260                 265                 270         


Ser Gly Gln Ala Val Ala Pro Ser Glu Gly Ala Asn Lys His Lys Gly 
        275                 280                 285             


Trp Ser Arg Gln Gly Leu Arg Arg Pro Ser Ile Leu Pro Glu Gly Ser 
    290                 295                 300                 


Ser Asp Ser Arg Gly Pro Ala Val Glu Lys His Pro Gly Pro Ser Asp 
305                 310                 315                 320 


Xaa Val Val Phe Arg Glu Lys Lys Pro Lys Glu Val Met Gly Gly Phe 
                325                 330                 335     


Ser Arg Arg Cys Ser Lys Leu Ile Asn Ser Ser Gln Leu Leu Tyr Gln 
            340                 345                 350         


Glu Tyr Ser Asp Val Val Leu Asn Lys Glu Ile Gln Ser Gln Gln Arg 
        355                 360                 365             


Leu Glu Ser Leu Ser Glu Xaa Pro Gly Pro Ser Ser Pro Arg Gln Pro 
    370                 375                 380                 


Arg Lys Ala Leu Val Ser Ser Glu Ser Tyr Leu Gln Arg Leu Ser Met 
385                 390                 395                 400 


Ala Ser Ser Gly Ser Leu Trp Gln Glu Ile Pro Val Val Arg Asn Ser 
                405                 410                 415     


Xaa Val Leu Leu Ser Met Xaa His Glu Asp Gln Lys Leu Gln Glu Val 
            420                 425                 430         


Lys Phe Glu Leu Ile Val Ser Glu Ala Ser Tyr Leu Arg Ser Leu Asn 
        435                 440                 445             


Ile Ala Val Asp His Phe Gln Leu Ser Xaa Ser Leu Arg Ala Xaa Leu 
    450                 455                 460                 


Ser Asn Gln Glu His Gln Trp Leu Phe Ser Arg Leu Gln Asp Val Arg 
465                 470                 475                 480 


Asp Val Ser Ala Xaa Phe Leu Ser Asp Leu Glu Glu Asn Phe Glu Asn 
                485                 490                 495     


Asn Ile Phe Ser Phe Gln Val Cys Asp Val Val Leu Asn His Ala Pro 
            500                 505                 510         


Asp Phe Arg Arg Val Tyr Leu Pro Tyr Val Xaa Asn Gln Xaa Tyr Gln 
        515                 520                 525             


Glu Arg Xaa Phe Gln Ser Leu Met Asn Ser Asn Ser Asn Phe Arg Glu 
    530                 535                 540                 


Val Leu Glu Lys Leu Glu Ser Asp Pro Val Cys Gln Arg Leu Ser Leu 
545                 550                 555                 560 


Lys Ser Phe Leu Ile Leu Pro Phe Gln Arg Ile Xaa Arg Leu Lys Leu 
                565                 570                 575     


Leu Leu Gln Asn Ile Leu Lys Arg Xaa Gln Pro Gly Ser Ser Glu Glu 
            580                 585                 590         


Ala Glu Ala Xaa Lys Ala His His Ala Leu Glu Gln Leu Ile Arg Asp 
        595                 600                 605             


Cys Asn Asn Asn Val Gln Ser Met Arg Arg Xaa Glu Glu Leu Ile Tyr 
    610                 615                 620                 


Leu Ser Gln Lys Ile Glu Phe Glu Cys Lys Ile Phe Pro Leu Ile Ser 
625                 630                 635                 640 


Gln Ser Arg Trp Leu Val Lys Ser Gly Glu Leu Xaa Ala Leu Glu Phe 
                645                 650                 655     


Ser Ala Ser Pro Gly Leu Arg Arg Lys Leu Asn Xaa Arg Pro Val His 
            660                 665                 670         


Leu His Leu Phe Asn Asp Cys Leu Leu Leu Ser Arg Pro Arg Glu Ser 
        675                 680                 685             


Glu Lys Leu Arg Trp Ile Ser Ala Leu Ala Met Pro Arg Glu Glu Leu 
    690                 695                 700                 


Asp Leu Leu Glu Cys Tyr Asn Ser Pro Gln Val Gln Cys Leu Arg Ala 
705                 710                 715                 720 


Tyr Lys Pro Arg Glu Asn Asp Glu Leu Ala Leu Glu Lys Ala Asp Val 
                725                 730                 735     


Val Met Val Xaa Gln Gln Ser Ser Asp Gly Trp Leu Glu Gly Val Arg 
            740                 745                 750         


Leu Ser Asp Gly Glu Arg Gly Trp Phe Pro Val Gln Gln Val Glu Phe 
        755                 760                 765             


Ile Ser Asn Pro Glu Val Arg Ala Gln Asn Leu Lys Glu Ala His Arg 
    770                 775                 780                 


Val Lys Xaa Ala Lys Leu Gln Leu Val Glu Gln Gln Ala 
785                 790                 795         


<210> 3053
<211> 776
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<400> 3053
Met Asn Pro Glu Glu Gln Ile Val Xaa Trp Leu Ile Ser Leu Gly Val 
1               5                   10                  15      


Leu Glu Ser Pro Lys Lys Xaa Ile Cys Asp Pro Glu Glu Phe Leu Lys 
            20                  25                  30          


Ser Ser Leu Lys Asn Gly Val Val Leu Cys Lys Leu Ile Asn Arg Leu 
        35                  40                  45              


Met Pro Gly Ser Val Glu Lys Phe Cys Leu Asp Pro Gln Xaa Glu Ala 
    50                  55                  60                  


Asp Cys Ile Asn Asn Ile Asn Asp Phe Leu Lys Gly Cys Ala Xaa Leu 
65                  70                  75                  80  


Gln Val Glu Ile Phe Asp Pro Asp Asp Leu Tyr Ser Gly Val Asn Phe 
                85                  90                  95      


Ser Lys Val Leu Ser Xaa Leu Leu Ala Val Asn Lys Ala Xaa Glu Asp 
            100                 105                 110         


Gln Leu Ser Glu Arg Pro Cys Gly Arg Ser Ser Ser Leu Ser Ala Ala 
        115                 120                 125             


Asn Xaa Ser Gln Xaa Asn Pro Gln Gly Ala Val Ser Ser Xaa Val Ser 
    130                 135                 140                 


Gly Leu Gln Arg Gln Ser Lys Xaa Val Glu Met Xaa Glu Asn Gly Ser 
145                 150                 155                 160 


His Gln Leu Ile Val Lys Ala Arg Phe Asn Phe Lys Gln Xaa Asn Glu 
                165                 170                 175     


Asp Glu Leu Ser Val Cys Lys Gly Asp Ile Ile Tyr Val Xaa Arg Val 
            180                 185                 190         


Glu Glu Gly Gly Trp Trp Glu Gly Xaa Leu Asn Gly Arg Xaa Gly Trp 
        195                 200                 205             


Phe Pro Ser Asn Tyr Val Arg Glu Ile Lys Ser Ser Glu Arg Pro Leu 
    210                 215                 220                 


Ser Pro Lys Ala Val Lys Gly Phe Glu Xaa Ala Pro Leu Xaa Lys Asn 
225                 230                 235                 240 


Tyr Tyr Xaa Val Val Leu Gln Asn Ile Leu Asp Xaa Glu Lys Glu Tyr 
                245                 250                 255     


Ala Lys Glu Leu Gln Ser Leu Leu Val Xaa Tyr Leu Arg Pro Leu Gln 
            260                 265                 270         


Ser Asn Asn Asn Leu Ser Xaa Val Glu Val Xaa Ser Leu Leu Gly Asn 
        275                 280                 285             


Phe Glu Glu Val Cys Xaa Phe Gln Gln Xaa Leu Cys Gln Ala Leu Glu 
    290                 295                 300                 


Glu Cys Ser Lys Phe Pro Glu Asn Gln His Lys Val Gly Gly Cys Leu 
305                 310                 315                 320 


Leu Ser Leu Met Pro His Phe Lys Ser Met Tyr Leu Ala Tyr Cys Ala 
                325                 330                 335     


Asn His Pro Ser Ala Val Asn Val Leu Xaa Gln His Ser Asp Glu Leu 
            340                 345                 350         


Glu Gln Phe Met Glu Asn Gln Gly Ala Ser Ser Pro Gly Ile Leu Ile 
        355                 360                 365             


Leu Xaa Xaa Asn Leu Ser Lys Pro Phe Met Arg Leu Glu Lys Tyr Val 
    370                 375                 380                 


Xaa Leu Leu Gln Glu Leu Glu Arg His Met Glu Asp Xaa His Pro Asp 
385                 390                 395                 400 


His Gln Asp Ile Leu Lys Ala Ile Val Ala Phe Lys Xaa Leu Met Gly 
                405                 410                 415     


Gln Cys Gln Asp Leu Arg Lys Arg Lys Gln Leu Glu Leu Gln Ile Leu 
            420                 425                 430         


Ser Glu Pro Ile Gln Ala Trp Glu Gly Glu Asp Ile Lys Asn Leu Gly 
        435                 440                 445             


Asn Val Ile Phe Met Ser Gln Val Met Val Gln Tyr Gly Ala Cys Glu 
    450                 455                 460                 


Glu Lys Glu Glu Arg Tyr Leu Met Leu Phe Ser Asn Val Leu Ile Met 
465                 470                 475                 480 


Leu Ser Ala Ser Pro Arg Met Ser Gly Phe Ile Tyr Gln Gly Lys Ile 
                485                 490                 495     


Pro Ile Ala Gly Xaa Val Val Xaa Arg Leu Asp Glu Ile Glu Gly Asn 
            500                 505                 510         


Asp Cys Xaa Phe Glu Ile Xaa Gly Asn Xaa Val Glu Arg Ile Val Val 
        515                 520                 525             


His Cys Asn Asn Asn Gln Asp Phe Gln Glu Trp Leu Glu Gln Leu Asn 
    530                 535                 540                 


Arg Leu Ile Arg Gly Pro Ala Ser Cys Ser Ser Leu Ser Lys Xaa Ser 
545                 550                 555                 560 


Ser Ser Ser Cys Ser Ala His Ser Ser Phe Ser Ser Xaa Gly Gln Pro 
                565                 570                 575     


Arg Gly Pro Leu Glu Pro Pro Gln Ile Ile Lys Pro Trp Ser Leu Ser 
            580                 585                 590         


Cys Leu Arg Pro Ala Pro Pro Leu Arg Pro Ser Ala Ala Leu Gly Tyr 
        595                 600                 605             


Lys Glu Arg Met Ser Tyr Ile Leu Lys Glu Ser Ser Lys Ser Pro Lys 
    610                 615                 620                 


Xaa Met Lys Lys Phe Leu His Lys Arg Lys Xaa Glu Arg Lys Pro Ser 
625                 630                 635                 640 


Glu Glu Glu Tyr Val Ile Arg Lys Ser Xaa Ala Ala Leu Glu Glu Asp 
                645                 650                 655     


Ala Gln Ile Leu Lys Val Ile Glu Ala Tyr Cys Xaa Ser Ala Asn Phe 
            660                 665                 670         


Gln Gln Gly His Gly Ser Ser Xaa Arg Lys Asp Ser Ile Pro Gln Val 
        675                 680                 685             


Leu Leu Pro Glu Glu Glu Lys Leu Ile Ile Glu Glu Xaa Arg Ser Asn 
    690                 695                 700                 


Gly Gln Xaa Ile Met Glu Glu Lys Ser Leu Val Asp Xaa Val Tyr Ala 
705                 710                 715                 720 


Leu Lys Asp Glu Val Arg Glu Leu Lys Gln Glu Asn Lys Arg Met Lys 
                725                 730                 735     


Gln Cys Leu Glu Glu Glu Leu Lys Ser Arg Arg Asp Leu Glu Lys Leu 
            740                 745                 750         


Val Arg Arg Leu Leu Lys Gln Xaa Asp Glu Cys Ile Arg Gly Glu Ser 
        755                 760                 765             


Ser Ser Lys Xaa Ser Ile Leu Pro 
    770                 775     


<210> 3054
<211> 622
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<400> 3054
Met Xaa Glu Asn Gly Ser His Gln Leu Ile Val Lys Ala Arg Phe Asn 
1               5                   10                  15      


Phe Lys Gln Xaa Asn Glu Asp Glu Leu Ser Val Cys Lys Gly Asp Ile 
            20                  25                  30          


Ile Tyr Val Xaa Arg Val Glu Glu Gly Gly Trp Trp Glu Gly Xaa Leu 
        35                  40                  45              


Asn Gly Arg Xaa Gly Trp Phe Pro Ser Asn Tyr Val Arg Glu Ile Lys 
    50                  55                  60                  


Ser Ser Glu Arg Pro Leu Ser Pro Lys Ala Val Lys Gly Phe Glu Xaa 
65                  70                  75                  80  


Ala Pro Leu Xaa Lys Asn Tyr Tyr Xaa Val Val Leu Gln Asn Ile Leu 
                85                  90                  95      


Asp Xaa Glu Lys Glu Tyr Ala Lys Glu Leu Gln Ser Leu Leu Val Xaa 
            100                 105                 110         


Tyr Leu Arg Pro Leu Gln Ser Asn Asn Asn Leu Ser Xaa Val Glu Val 
        115                 120                 125             


Xaa Ser Leu Leu Gly Asn Phe Glu Glu Val Cys Xaa Phe Gln Gln Xaa 
    130                 135                 140                 


Leu Cys Gln Ala Leu Glu Glu Cys Ser Lys Phe Pro Glu Asn Gln His 
145                 150                 155                 160 


Lys Val Gly Gly Cys Leu Leu Ser Leu Met Pro His Phe Lys Ser Met 
                165                 170                 175     


Tyr Leu Ala Tyr Cys Ala Asn His Pro Ser Ala Val Asn Val Leu Xaa 
            180                 185                 190         


Gln His Ser Asp Glu Leu Glu Gln Phe Met Glu Asn Gln Gly Ala Ser 
        195                 200                 205             


Ser Pro Gly Ile Leu Ile Leu Xaa Xaa Asn Leu Ser Lys Pro Phe Met 
    210                 215                 220                 


Arg Leu Glu Lys Tyr Val Xaa Leu Leu Gln Glu Leu Glu Arg His Met 
225                 230                 235                 240 


Glu Asp Xaa His Pro Asp His Gln Asp Ile Leu Lys Ala Ile Val Ala 
                245                 250                 255     


Phe Lys Xaa Leu Met Gly Gln Cys Gln Asp Leu Arg Lys Arg Lys Gln 
            260                 265                 270         


Leu Glu Leu Gln Ile Leu Ser Glu Pro Ile Gln Ala Trp Glu Gly Glu 
        275                 280                 285             


Asp Ile Lys Asn Leu Gly Asn Val Ile Phe Met Ser Gln Val Met Val 
    290                 295                 300                 


Gln Tyr Gly Ala Cys Glu Glu Lys Glu Glu Arg Tyr Leu Met Leu Phe 
305                 310                 315                 320 


Ser Asn Val Leu Ile Met Leu Ser Ala Ser Pro Arg Met Ser Gly Phe 
                325                 330                 335     


Ile Tyr Gln Gly Lys Ile Pro Ile Ala Gly Xaa Val Val Xaa Arg Leu 
            340                 345                 350         


Asp Glu Ile Glu Gly Asn Asp Cys Xaa Phe Glu Ile Xaa Gly Asn Xaa 
        355                 360                 365             


Val Glu Arg Ile Val Val His Cys Asn Asn Asn Gln Asp Phe Gln Glu 
    370                 375                 380                 


Trp Leu Glu Gln Leu Asn Arg Leu Ile Arg Gly Pro Ala Ser Cys Ser 
385                 390                 395                 400 


Ser Leu Ser Lys Xaa Ser Ser Ser Ser Cys Ser Ala His Ser Ser Phe 
                405                 410                 415     


Ser Ser Xaa Gly Gln Pro Arg Gly Pro Leu Glu Pro Pro Gln Ile Ile 
            420                 425                 430         


Lys Pro Trp Ser Leu Ser Cys Leu Arg Pro Ala Pro Pro Leu Arg Pro 
        435                 440                 445             


Ser Ala Ala Leu Gly Tyr Lys Glu Arg Met Ser Tyr Ile Leu Lys Glu 
    450                 455                 460                 


Ser Ser Lys Ser Pro Lys Xaa Met Lys Lys Phe Leu His Lys Arg Lys 
465                 470                 475                 480 


Xaa Glu Arg Lys Pro Ser Glu Glu Glu Tyr Val Ile Arg Lys Ser Xaa 
                485                 490                 495     


Ala Ala Leu Glu Glu Asp Ala Gln Ile Leu Lys Val Ile Glu Ala Tyr 
            500                 505                 510         


Cys Xaa Ser Ala Asn Phe Gln Gln Gly His Gly Ser Ser Xaa Arg Lys 
        515                 520                 525             


Asp Ser Ile Pro Gln Val Leu Leu Pro Glu Glu Glu Lys Leu Ile Ile 
    530                 535                 540                 


Glu Glu Xaa Arg Ser Asn Gly Gln Xaa Ile Met Glu Glu Lys Ser Leu 
545                 550                 555                 560 


Val Asp Xaa Val Tyr Ala Leu Lys Asp Glu Val Arg Glu Leu Lys Gln 
                565                 570                 575     


Glu Asn Lys Arg Met Lys Gln Cys Leu Glu Glu Glu Leu Lys Ser Arg 
            580                 585                 590         


Arg Asp Leu Glu Lys Leu Val Arg Arg Leu Leu Lys Gln Xaa Asp Glu 
        595                 600                 605             


Cys Ile Arg Gly Glu Ser Ser Ser Lys Xaa Ser Ile Leu Pro 
    610                 615                 620         


<210> 3055
<211> 547
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<400> 3055
Met Gly Ser Cys Ser Ser Gln Ser Val Gln Lys Xaa Arg Arg Gly Arg 
1               5                   10                  15      


Lys Val Val Leu Gln Asn Ile Leu Glu Xaa Glu Asn Glu Tyr Ser Lys 
            20                  25                  30          


Glu Leu Gln Xaa Val Leu Ser Xaa Tyr Leu Arg Pro Leu Gln Xaa Ser 
        35                  40                  45              


Glu Lys Leu Ser Ser Ala Asn Ile Ser Tyr Leu Met Gly Asn Leu Glu 
    50                  55                  60                  


Glu Ile Cys Ser Phe Gln Gln Met Leu Val Gln Ser Leu Glu Glu Cys 
65                  70                  75                  80  


Xaa Lys Leu Pro Glu Ala Gln Gln Arg Val Gly Gly Cys Phe Leu Asn 
                85                  90                  95      


Leu Met Pro Gln Met Lys Xaa Leu Tyr Leu Xaa Tyr Cys Ala Asn His 
            100                 105                 110         


Pro Ser Ala Val Asn Val Leu Xaa Glu His Ser Glu Glu Leu Gly Glu 
        115                 120                 125             


Phe Met Glu Xaa Lys Gly Ala Ser Ser Pro Gly Ile Leu Val Leu Xaa 
    130                 135                 140                 


Xaa Gly Leu Ser Lys Pro Phe Met Arg Leu Asp Lys Tyr Pro Xaa Leu 
145                 150                 155                 160 


Leu Lys Glu Leu Glu Arg His Met Glu Asp Tyr His Xaa Asp Arg Gln 
                165                 170                 175     


Asp Ile Gln Lys Ser Met Ala Ala Phe Lys Asn Leu Ser Ala Gln Cys 
            180                 185                 190         


Gln Glu Val Arg Lys Arg Lys Glu Leu Glu Leu Gln Ile Leu Xaa Glu 
        195                 200                 205             


Ala Ile Arg Asn Trp Glu Gly Asp Asp Ile Lys Xaa Leu Gly Asn Val 
    210                 215                 220                 


Xaa Tyr Met Ser Gln Val Leu Ile Gln Cys Ala Gly Ser Glu Glu Lys 
225                 230                 235                 240 


Asn Glu Arg Tyr Leu Leu Leu Phe Pro Asn Val Leu Leu Met Leu Ser 
                245                 250                 255     


Ala Ser Pro Arg Met Ser Gly Phe Ile Tyr Gln Gly Lys Leu Pro Xaa 
            260                 265                 270         


Xaa Gly Met Xaa Ile Xaa Lys Leu Glu Asp Ser Glu Asn His Arg Asn 
        275                 280                 285             


Ala Phe Glu Ile Ser Gly Ser Met Ile Glu Arg Ile Leu Val Ser Cys 
    290                 295                 300                 


Asn Asn Gln Gln Asp Leu Gln Glu Trp Val Glu His Leu Gln Lys Gln 
305                 310                 315                 320 


Xaa Lys Val Xaa Ser Val Gly Asn Pro Xaa Ile Lys Pro His Ser Val 
                325                 330                 335     


Pro Ser His Xaa Leu Pro Ser His Pro Val Xaa Pro Ser Ser Lys His 
            340                 345                 350         


Ala Asp Ser Lys Pro Ala Pro Leu Xaa Pro Ala Tyr His Xaa Leu Pro 
        355                 360                 365             


His Pro Ser His His Gly Xaa Pro His Xaa Xaa Ile Asn Trp Gly Pro 
    370                 375                 380                 


Leu Glu Pro Pro Lys Xaa Pro Lys Pro Trp Ser Leu Ser Cys Leu Arg 
385                 390                 395                 400 


Pro Ala Pro Pro Leu Arg Pro Ser Ala Ala Leu Cys Tyr Lys Glu Asp 
                405                 410                 415     


Leu Ser Lys Ser Pro Lys Xaa Met Lys Lys Leu Leu Pro Lys Arg Lys 
            420                 425                 430         


Pro Glu Arg Lys Pro Ser Asp Glu Glu Phe Ala Ser Arg Lys Ser Xaa 
        435                 440                 445             


Ala Ala Leu Glu Glu Asp Ala Gln Ile Leu Lys Val Ile Glu Ala Tyr 
    450                 455                 460                 


Cys Xaa Ser Ala Lys Xaa Arg Gln Xaa Leu Asn Ser Xaa Trp Gln Gly 
465                 470                 475                 480 


Xaa Asp Leu Met His Asn His Val Leu Ala Asp Asp Asp Gln Pro Ser 
                485                 490                 495     


Leu Asp Ser Leu Gly Arg Arg Ser Ser Leu Ser Arg Leu Glu Pro Ser 
            500                 505                 510         


Asp Leu Ser Glu Asp Ser Asp Tyr Asp Ser Ile Trp Xaa Ala His Ser 
        515                 520                 525             


Tyr Arg Met Gly Ser Xaa Ser Arg Lys Ser Cys Cys Ser Tyr Ile Ser 
    530                 535                 540                 


His Gln Asn 
545         


<210> 3056
<211> 143
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 3056
Met Lys Xaa Phe Asp Ala Asn Asp Leu Tyr Gln Gly Gln Asn Phe Asn 
1               5                   10                  15      


Lys Val Leu Ser Ser Leu Val Xaa Leu Asn Lys Val Xaa Ala Asp Ile 
            20                  25                  30          


Gly Leu Gly Ser Asp Ser Val Cys Ala Arg Pro Ser Ser His Arg Ile 
        35                  40                  45              


Lys Ser Phe Asp Ser Leu Gly Ser Gln Ser Leu His Xaa Arg Xaa Ser 
    50                  55                  60                  


Lys Leu Phe Gln Gly Gln Tyr Arg Ser Leu Asp Met Xaa Asp Asn Ser 
65                  70                  75                  80  


Asn Asn Gln Leu Val Val Arg Ala Lys Phe Asn Phe Gln Gln Xaa Asn 
                85                  90                  95      


Glu Asp Glu Leu Ser Phe Ser Lys Gly Asp Val Ile His Val Xaa Arg 
            100                 105                 110         


Val Glu Glu Gly Gly Trp Trp Glu Gly Xaa Leu Asn Gly Arg Xaa Gly 
        115                 120                 125             


Trp Phe Pro Ser Asn Tyr Val Arg Glu Val Lys Ala Ser Gly Lys 
    130                 135                 140             


<210> 3057
<211> 753
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<400> 3057
Met Asn Ser Ala Glu Gln Xaa Val Xaa Trp Leu Ile Xaa Leu Gly Val 
1               5                   10                  15      


Leu Glu Ser Pro Lys Lys Xaa Ile Ser Asp Pro Glu Gly Phe Leu Gln 
            20                  25                  30          


Ala Ser Leu Lys Asp Gly Val Val Leu Cys Arg Leu Leu Glu Arg Leu 
        35                  40                  45              


Leu Pro Gly Xaa Ile Glu Lys Xaa Phe Asp Ala Asn Asp Leu Tyr Gln 
    50                  55                  60                  


Gly Gln Asn Phe Asn Lys Val Leu Ser Ser Leu Val Xaa Leu Asn Lys 
65                  70                  75                  80  


Val Xaa Ala Asp Ile Gly Leu Gly Ser Asp Ser Val Cys Ala Arg Pro 
                85                  90                  95      


Ser Ser His Arg Ile Lys Ser Phe Asp Ser Leu Gly Ser Gln Ser Leu 
            100                 105                 110         


His Xaa Arg Xaa Ser Lys Leu Phe Gln Gly Gln Tyr Arg Ser Leu Asp 
        115                 120                 125             


Met Xaa Asp Asn Ser Asn Asn Gln Leu Val Val Arg Ala Lys Phe Asn 
    130                 135                 140                 


Phe Gln Gln Xaa Asn Glu Asp Glu Leu Ser Phe Ser Lys Gly Asp Val 
145                 150                 155                 160 


Ile His Val Xaa Arg Val Glu Glu Gly Gly Trp Trp Glu Gly Xaa Leu 
                165                 170                 175     


Asn Gly Arg Xaa Gly Trp Phe Pro Ser Asn Tyr Val Arg Glu Val Lys 
            180                 185                 190         


Ala Ser Glu Lys Pro Val Ser Pro Lys Ser Gly Xaa Leu Lys Ser Pro 
        195                 200                 205             


Pro Lys Gly Phe Asp Xaa Xaa Ala Ile Asn Lys Ser Tyr Tyr Asn Val 
    210                 215                 220                 


Val Leu Gln Asn Ile Leu Glu Xaa Glu Asn Glu Tyr Ser Lys Glu Leu 
225                 230                 235                 240 


Gln Xaa Val Leu Ser Xaa Tyr Leu Arg Pro Leu Gln Xaa Ser Glu Lys 
                245                 250                 255     


Leu Ser Ser Ala Asn Ile Ser Tyr Leu Met Gly Asn Leu Glu Glu Ile 
            260                 265                 270         


Cys Ser Phe Gln Gln Met Leu Val Gln Ser Leu Glu Glu Cys Xaa Lys 
        275                 280                 285             


Leu Pro Glu Ala Gln Gln Arg Val Gly Gly Cys Phe Leu Asn Leu Met 
    290                 295                 300                 


Pro Gln Met Lys Xaa Leu Tyr Leu Xaa Tyr Cys Ala Asn His Pro Ser 
305                 310                 315                 320 


Ala Val Asn Val Leu Xaa Glu His Ser Glu Glu Leu Gly Glu Phe Met 
                325                 330                 335     


Glu Xaa Lys Gly Ala Ser Ser Pro Gly Ile Leu Val Leu Xaa Xaa Gly 
            340                 345                 350         


Leu Ser Lys Pro Phe Met Arg Leu Asp Lys Tyr Pro Xaa Leu Leu Lys 
        355                 360                 365             


Glu Leu Glu Arg His Met Glu Asp Tyr His Xaa Asp Arg Gln Asp Ile 
    370                 375                 380                 


Gln Lys Ser Met Ala Ala Phe Lys Asn Leu Ser Ala Gln Cys Gln Glu 
385                 390                 395                 400 


Val Arg Lys Arg Lys Glu Leu Glu Leu Gln Ile Leu Xaa Glu Ala Ile 
                405                 410                 415     


Arg Asn Trp Glu Gly Asp Asp Ile Lys Xaa Leu Gly Asn Val Xaa Tyr 
            420                 425                 430         


Met Ser Gln Val Leu Ile Gln Cys Ala Gly Ser Glu Glu Lys Asn Glu 
        435                 440                 445             


Arg Tyr Leu Leu Leu Phe Pro Asn Val Leu Leu Met Leu Ser Ala Ser 
    450                 455                 460                 


Pro Arg Met Ser Gly Phe Ile Tyr Gln Gly Lys Leu Pro Xaa Xaa Gly 
465                 470                 475                 480 


Met Xaa Ile Xaa Lys Leu Glu Asp Ser Glu Asn His Arg Asn Ala Phe 
                485                 490                 495     


Glu Ile Ser Gly Ser Met Ile Glu Arg Ile Leu Val Ser Cys Asn Asn 
            500                 505                 510         


Gln Gln Asp Leu Gln Glu Trp Val Glu His Leu Gln Lys Gln Xaa Lys 
        515                 520                 525             


Val Xaa Ser Val Gly Asn Pro Xaa Ile Lys Pro His Ser Val Pro Ser 
    530                 535                 540                 


His Xaa Leu Pro Ser His Pro Val Xaa Pro Ser Ser Lys His Ala Asp 
545                 550                 555                 560 


Ser Lys Pro Ala Pro Leu Xaa Pro Ala Tyr His Xaa Leu Pro His Pro 
                565                 570                 575     


Ser His His Gly Xaa Pro His Xaa Xaa Ile Asn Trp Gly Pro Leu Glu 
            580                 585                 590         


Pro Pro Lys Xaa Pro Lys Pro Trp Ser Leu Ser Cys Leu Arg Pro Ala 
        595                 600                 605             


Pro Pro Leu Arg Pro Ser Ala Ala Leu Cys Tyr Lys Glu Asp Leu Ser 
    610                 615                 620                 


Lys Ser Pro Lys Xaa Met Lys Lys Leu Leu Pro Lys Arg Lys Pro Glu 
625                 630                 635                 640 


Arg Lys Pro Ser Asp Glu Glu Phe Ala Ser Arg Lys Ser Xaa Ala Ala 
                645                 650                 655     


Leu Glu Glu Asp Ala Gln Ile Leu Lys Val Ile Glu Ala Tyr Cys Xaa 
            660                 665                 670         


Ser Ala Lys Xaa Arg Gln Xaa Leu Asn Ser Xaa Trp Gln Gly Xaa Asp 
        675                 680                 685             


Leu Met His Asn His Val Leu Ala Asp Asp Asp Gln Pro Ser Leu Asp 
    690                 695                 700                 


Ser Leu Gly Arg Arg Ser Ser Leu Ser Arg Leu Glu Pro Ser Asp Leu 
705                 710                 715                 720 


Ser Glu Asp Ser Asp Tyr Asp Ser Ile Trp Xaa Ala His Ser Tyr Arg 
                725                 730                 735     


Met Gly Ser Xaa Ser Arg Lys Ser Cys Cys Ser Tyr Ile Ser His Gln 
            740                 745                 750         


Asn 
    


<210> 3058
<211> 803
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<400> 3058
Met Asn Ser Ala Glu Gln Xaa Val Xaa Trp Leu Ile Xaa Leu Gly Val 
1               5                   10                  15      


Leu Glu Ser Pro Lys Lys Xaa Ile Ser Asp Pro Glu Gly Phe Leu Gln 
            20                  25                  30          


Ala Ser Leu Lys Asp Gly Val Val Leu Cys Arg Leu Leu Glu Arg Leu 
        35                  40                  45              


Leu Pro Gly Xaa Ile Glu Lys Val Tyr Pro Glu Pro Arg Ser Glu Ser 
    50                  55                  60                  


Glu Cys Leu Ser Asn Ile Arg Glu Phe Leu Arg Gly Cys Gly Ala Ser 
65                  70                  75                  80  


Leu Arg Leu Glu Leu Leu Phe Pro Pro Ser Gln Pro Pro Gln His Leu 
                85                  90                  95      


Val Xaa Xaa Ile Leu Leu Ser Ala Ser Xaa Phe Asp Ala Asn Asp Leu 
            100                 105                 110         


Tyr Gln Gly Gln Asn Phe Asn Lys Val Leu Ser Ser Leu Val Xaa Leu 
        115                 120                 125             


Asn Lys Val Xaa Ala Asp Ile Gly Leu Gly Ser Asp Ser Val Cys Ala 
    130                 135                 140                 


Arg Pro Ser Ser His Arg Ile Lys Ser Phe Asp Ser Leu Gly Ser Gln 
145                 150                 155                 160 


Ser Leu His Xaa Arg Xaa Ser Lys Leu Phe Gln Gly Gln Tyr Arg Ser 
                165                 170                 175     


Leu Asp Met Xaa Asp Asn Ser Asn Asn Gln Leu Val Val Arg Ala Lys 
            180                 185                 190         


Phe Asn Phe Gln Gln Xaa Asn Glu Asp Glu Leu Ser Phe Ser Lys Gly 
        195                 200                 205             


Asp Val Ile His Val Xaa Arg Val Glu Glu Gly Gly Trp Trp Glu Gly 
    210                 215                 220                 


Xaa Leu Asn Gly Arg Xaa Gly Trp Phe Pro Ser Asn Tyr Val Arg Glu 
225                 230                 235                 240 


Val Lys Ala Ser Glu Lys Pro Val Ser Pro Lys Ser Gly Xaa Leu Lys 
                245                 250                 255     


Ser Pro Pro Lys Gly Phe Asp Xaa Xaa Ala Ile Asn Lys Ser Tyr Tyr 
            260                 265                 270         


Asn Val Val Leu Gln Asn Ile Leu Glu Xaa Glu Asn Glu Tyr Ser Lys 
        275                 280                 285             


Glu Leu Gln Xaa Val Leu Ser Xaa Tyr Leu Arg Pro Leu Gln Xaa Ser 
    290                 295                 300                 


Glu Lys Leu Ser Ser Ala Asn Ile Ser Tyr Leu Met Gly Asn Leu Glu 
305                 310                 315                 320 


Glu Ile Cys Ser Phe Gln Gln Met Leu Val Gln Ser Leu Glu Glu Cys 
                325                 330                 335     


Xaa Lys Leu Pro Glu Ala Gln Gln Arg Val Gly Gly Cys Phe Leu Asn 
            340                 345                 350         


Leu Met Pro Gln Met Lys Xaa Leu Tyr Leu Xaa Tyr Cys Ala Asn His 
        355                 360                 365             


Pro Ser Ala Val Asn Val Leu Xaa Glu His Ser Glu Glu Leu Gly Glu 
    370                 375                 380                 


Phe Met Glu Xaa Lys Gly Ala Ser Ser Pro Gly Ile Leu Val Leu Xaa 
385                 390                 395                 400 


Xaa Gly Leu Ser Lys Pro Phe Met Arg Leu Asp Lys Tyr Pro Xaa Leu 
                405                 410                 415     


Leu Lys Glu Leu Glu Arg His Met Glu Asp Tyr His Xaa Asp Arg Gln 
            420                 425                 430         


Asp Ile Gln Lys Ser Met Ala Ala Phe Lys Asn Leu Ser Ala Gln Cys 
        435                 440                 445             


Gln Glu Val Arg Lys Arg Lys Glu Leu Glu Leu Gln Ile Leu Xaa Glu 
    450                 455                 460                 


Ala Ile Arg Asn Trp Glu Gly Asp Asp Ile Lys Xaa Leu Gly Asn Val 
465                 470                 475                 480 


Xaa Tyr Met Ser Gln Val Leu Ile Gln Cys Ala Gly Ser Glu Glu Lys 
                485                 490                 495     


Asn Glu Arg Tyr Leu Leu Leu Phe Pro Asn Val Leu Leu Met Leu Ser 
            500                 505                 510         


Ala Ser Pro Arg Met Ser Gly Phe Ile Tyr Gln Gly Lys Leu Pro Xaa 
        515                 520                 525             


Xaa Gly Met Xaa Ile Xaa Lys Leu Glu Asp Ser Glu Asn His Arg Asn 
    530                 535                 540                 


Ala Phe Glu Ile Ser Gly Ser Met Ile Glu Arg Ile Leu Val Ser Cys 
545                 550                 555                 560 


Asn Asn Gln Gln Asp Leu Gln Glu Trp Val Glu His Leu Gln Lys Gln 
                565                 570                 575     


Xaa Lys Val Xaa Ser Val Gly Asn Pro Xaa Ile Lys Pro His Ser Val 
            580                 585                 590         


Pro Ser His Xaa Leu Pro Ser His Pro Val Xaa Pro Ser Ser Lys His 
        595                 600                 605             


Ala Asp Ser Lys Pro Ala Pro Leu Xaa Pro Ala Tyr His Xaa Leu Pro 
    610                 615                 620                 


His Pro Ser His His Gly Xaa Pro His Xaa Xaa Ile Asn Trp Gly Pro 
625                 630                 635                 640 


Leu Glu Pro Pro Lys Xaa Pro Lys Pro Trp Ser Leu Ser Cys Leu Arg 
                645                 650                 655     


Pro Ala Pro Pro Leu Arg Pro Ser Ala Ala Leu Cys Tyr Lys Glu Asp 
            660                 665                 670         


Leu Ser Lys Ser Pro Lys Xaa Met Lys Lys Leu Leu Pro Lys Arg Lys 
        675                 680                 685             


Pro Glu Arg Lys Pro Ser Asp Glu Glu Phe Ala Ser Arg Lys Ser Xaa 
    690                 695                 700                 


Ala Ala Leu Glu Glu Asp Ala Gln Ile Leu Lys Val Ile Glu Ala Tyr 
705                 710                 715                 720 


Cys Xaa Ser Ala Lys Xaa Arg Gln Xaa Leu Asn Ser Xaa Trp Gln Gly 
                725                 730                 735     


Xaa Asp Leu Met His Asn His Val Leu Ala Asp Asp Asp Gln Pro Ser 
            740                 745                 750         


Leu Asp Ser Leu Gly Arg Arg Ser Ser Leu Ser Arg Leu Glu Pro Ser 
        755                 760                 765             


Asp Leu Ser Glu Asp Ser Asp Tyr Asp Ser Ile Trp Xaa Ala His Ser 
    770                 775                 780                 


Tyr Arg Met Gly Ser Xaa Ser Arg Lys Ser Cys Cys Ser Tyr Ile Ser 
785                 790                 795                 800 


His Gln Asn 
            


<210> 3059
<211> 782
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<400> 3059
Met Asn Ser Ala Glu Gln Xaa Val Xaa Trp Leu Ile Xaa Leu Gly Val 
1               5                   10                  15      


Leu Glu Ser Pro Lys Lys Xaa Ile Ser Asp Pro Glu Gly Phe Leu Gln 
            20                  25                  30          


Ala Ser Leu Lys Asp Gly Val Val Leu Cys Arg Leu Leu Glu Arg Leu 
        35                  40                  45              


Leu Pro Gly Xaa Ile Glu Lys Val Tyr Pro Glu Pro Arg Ser Glu Ser 
    50                  55                  60                  


Glu Cys Leu Ser Asn Ile Arg Glu Phe Leu Arg Gly Cys Gly Ala Ser 
65                  70                  75                  80  


Leu Arg Leu Glu Xaa Phe Asp Ala Asn Asp Leu Tyr Gln Gly Gln Asn 
                85                  90                  95      


Phe Asn Lys Val Leu Ser Ser Leu Val Xaa Leu Asn Lys Val Xaa Ala 
            100                 105                 110         


Asp Ile Gly Leu Gly Ser Asp Ser Val Cys Ala Arg Pro Ser Ser His 
        115                 120                 125             


Arg Ile Lys Ser Phe Asp Ser Leu Gly Ser Gln Ser Leu His Xaa Arg 
    130                 135                 140                 


Xaa Ser Lys Leu Phe Gln Gly Gln Tyr Arg Ser Leu Asp Met Xaa Asp 
145                 150                 155                 160 


Asn Ser Asn Asn Gln Leu Val Val Arg Ala Lys Phe Asn Phe Gln Gln 
                165                 170                 175     


Xaa Asn Glu Asp Glu Leu Ser Phe Ser Lys Gly Asp Val Ile His Val 
            180                 185                 190         


Xaa Arg Val Glu Glu Gly Gly Trp Trp Glu Gly Xaa Leu Asn Gly Arg 
        195                 200                 205             


Xaa Gly Trp Phe Pro Ser Asn Tyr Val Arg Glu Val Lys Ala Ser Glu 
    210                 215                 220                 


Lys Pro Val Ser Pro Lys Ser Gly Xaa Leu Lys Ser Pro Pro Lys Gly 
225                 230                 235                 240 


Phe Asp Xaa Xaa Ala Ile Asn Lys Ser Tyr Tyr Asn Val Val Leu Gln 
                245                 250                 255     


Asn Ile Leu Glu Xaa Glu Asn Glu Tyr Ser Lys Glu Leu Gln Xaa Val 
            260                 265                 270         


Leu Ser Xaa Tyr Leu Arg Pro Leu Gln Xaa Ser Glu Lys Leu Ser Ser 
        275                 280                 285             


Ala Asn Ile Ser Tyr Leu Met Gly Asn Leu Glu Glu Ile Cys Ser Phe 
    290                 295                 300                 


Gln Gln Met Leu Val Gln Ser Leu Glu Glu Cys Xaa Lys Leu Pro Glu 
305                 310                 315                 320 


Ala Gln Gln Arg Val Gly Gly Cys Phe Leu Asn Leu Met Pro Gln Met 
                325                 330                 335     


Lys Xaa Leu Tyr Leu Xaa Tyr Cys Ala Asn His Pro Ser Ala Val Asn 
            340                 345                 350         


Val Leu Xaa Glu His Ser Glu Glu Leu Gly Glu Phe Met Glu Xaa Lys 
        355                 360                 365             


Gly Ala Ser Ser Pro Gly Ile Leu Val Leu Xaa Xaa Gly Leu Ser Lys 
    370                 375                 380                 


Pro Phe Met Arg Leu Asp Lys Tyr Pro Xaa Leu Leu Lys Glu Leu Glu 
385                 390                 395                 400 


Arg His Met Glu Asp Tyr His Xaa Asp Arg Gln Asp Ile Gln Lys Ser 
                405                 410                 415     


Met Ala Ala Phe Lys Asn Leu Ser Ala Gln Cys Gln Glu Val Arg Lys 
            420                 425                 430         


Arg Lys Glu Leu Glu Leu Gln Ile Leu Xaa Glu Ala Ile Arg Asn Trp 
        435                 440                 445             


Glu Gly Asp Asp Ile Lys Xaa Leu Gly Asn Val Xaa Tyr Met Ser Gln 
    450                 455                 460                 


Val Leu Ile Gln Cys Ala Gly Ser Glu Glu Lys Asn Glu Arg Tyr Leu 
465                 470                 475                 480 


Leu Leu Phe Pro Asn Val Leu Leu Met Leu Ser Ala Ser Pro Arg Met 
                485                 490                 495     


Ser Gly Phe Ile Tyr Gln Gly Lys Leu Pro Xaa Xaa Gly Met Xaa Ile 
            500                 505                 510         


Xaa Lys Leu Glu Asp Ser Glu Asn His Arg Asn Ala Phe Glu Ile Ser 
        515                 520                 525             


Gly Ser Met Ile Glu Arg Ile Leu Val Ser Cys Asn Asn Gln Gln Asp 
    530                 535                 540                 


Leu Gln Glu Trp Val Glu His Leu Gln Lys Gln Xaa Lys Val Xaa Ser 
545                 550                 555                 560 


Val Gly Asn Pro Xaa Ile Lys Pro His Ser Val Pro Ser His Xaa Leu 
                565                 570                 575     


Pro Ser His Pro Val Xaa Pro Ser Ser Lys His Ala Asp Ser Lys Pro 
            580                 585                 590         


Ala Pro Leu Xaa Pro Ala Tyr His Xaa Leu Pro His Pro Ser His His 
        595                 600                 605             


Gly Xaa Pro His Xaa Xaa Ile Asn Trp Gly Pro Leu Glu Pro Pro Lys 
    610                 615                 620                 


Xaa Pro Lys Pro Trp Ser Leu Ser Cys Leu Arg Pro Ala Pro Pro Leu 
625                 630                 635                 640 


Arg Pro Ser Ala Ala Leu Cys Tyr Lys Glu Asp Leu Ser Lys Ser Pro 
                645                 650                 655     


Lys Xaa Met Lys Lys Leu Leu Pro Lys Arg Lys Pro Glu Arg Lys Pro 
            660                 665                 670         


Ser Asp Glu Glu Phe Ala Ser Arg Lys Ser Xaa Ala Ala Leu Glu Glu 
        675                 680                 685             


Asp Ala Gln Ile Leu Lys Val Ile Glu Ala Tyr Cys Xaa Ser Ala Lys 
    690                 695                 700                 


Xaa Arg Gln Xaa Leu Asn Ser Xaa Trp Gln Gly Xaa Asp Leu Met His 
705                 710                 715                 720 


Asn His Val Leu Ala Asp Asp Asp Gln Pro Ser Leu Asp Ser Leu Gly 
                725                 730                 735     


Arg Arg Ser Ser Leu Ser Arg Leu Glu Pro Ser Asp Leu Ser Glu Asp 
            740                 745                 750         


Ser Asp Tyr Asp Ser Ile Trp Xaa Ala His Ser Tyr Arg Met Gly Ser 
        755                 760                 765             


Xaa Ser Arg Lys Ser Cys Cys Ser Tyr Ile Ser His Gln Asn 
    770                 775                 780         


<210> 3060
<211> 39
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<400> 3060
Met Xaa Asp Asn Ser Asn Asn Gln Leu Val Val Arg Ala Lys Phe Asn 
1               5                   10                  15      


Phe Gln Gln Xaa Asn Glu Asp Glu Leu Ser Phe Ser Lys Gly Asp Val 
            20                  25                  30          


Ile His Val Xaa Arg Val Glu 
        35                  


<210> 3061
<211> 61
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 3061
Met Xaa Asp Asn Ser Asn Asn Gln Leu Val Val Arg Ala Lys Phe Asn 
1               5                   10                  15      


Phe Gln Gln Xaa Asn Glu Asp Glu Leu Ser Phe Ser Lys Gly Asp Val 
            20                  25                  30          


Ile His Val Xaa Arg Val Glu Glu Gly Gly Trp Trp Glu Gly Xaa Leu 
        35                  40                  45              


Asn Gly Arg Xaa Gly Trp Phe Pro Ser Asn Tyr Val Arg 
    50                  55                  60      


<210> 3062
<211> 66
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 3062
Met Xaa Asp Asn Ser Asn Asn Gln Leu Val Val Arg Ala Lys Phe Asn 
1               5                   10                  15      


Phe Gln Gln Xaa Asn Glu Asp Glu Leu Ser Phe Ser Lys Gly Asp Val 
            20                  25                  30          


Ile His Val Xaa Arg Val Glu Glu Gly Gly Trp Trp Glu Gly Xaa Leu 
        35                  40                  45              


Asn Gly Arg Xaa Gly Trp Phe Pro Ser Asn Tyr Val Arg Glu Val Lys 
    50                  55                  60                  


Ala Ser 
65      


<210> 3063
<211> 151
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<400> 3063
Met Xaa Asp Asn Ser Asn Asn Gln Leu Val Val Arg Ala Lys Phe Asn 
1               5                   10                  15      


Phe Gln Gln Xaa Asn Glu Asp Glu Leu Ser Phe Ser Lys Gly Asp Val 
            20                  25                  30          


Ile His Val Xaa Arg Val Glu Glu Gly Gly Trp Trp Glu Gly Xaa Leu 
        35                  40                  45              


Asn Gly Arg Xaa Gly Trp Phe Pro Ser Asn Tyr Val Arg Glu Val Lys 
    50                  55                  60                  


Ala Ser Glu Lys Pro Val Ser Pro Lys Ser Gly Xaa Leu Lys Ser Pro 
65                  70                  75                  80  


Pro Lys Gly Phe Asp Xaa Xaa Ala Ile Asn Lys Ser Tyr Tyr Asn Val 
                85                  90                  95      


Pro Val Leu Ser Arg Gly Ala Glu Ser Ser Ala His Glu Gly Gly Gly 
            100                 105                 110         


Xaa Pro Arg Asp Cys Met Glu Val Glu Pro Gly Ser Pro Gly Ser Glu 
        115                 120                 125             


Val Leu Pro Ala Gly Leu Lys Gly Met Pro Ala Ser Arg His Ile Trp 
    130                 135                 140                 


Glu Pro Glu Cys Ala Val Val 
145                 150     


<210> 3064
<211> 447
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<400> 3064
Met Xaa Asp Asn Ser Asn Asn Gln Leu Val Val Arg Ala Lys Phe Asn 
1               5                   10                  15      


Phe Gln Gln Xaa Asn Glu Asp Glu Leu Ser Phe Ser Lys Gly Asp Val 
            20                  25                  30          


Ile His Val Xaa Arg Val Glu Glu Gly Gly Trp Trp Glu Gly Xaa Leu 
        35                  40                  45              


Asn Gly Arg Xaa Gly Trp Phe Pro Ser Asn Tyr Val Arg Glu Val Lys 
    50                  55                  60                  


Ala Ser Glu Lys Pro Val Ser Pro Lys Ser Gly Xaa Leu Lys Ser Pro 
65                  70                  75                  80  


Pro Lys Gly Phe Asp Xaa Xaa Ala Ile Asn Lys Ser Tyr Tyr Asn Val 
                85                  90                  95      


Val Leu Gln Asn Ile Leu Glu Xaa Glu Asn Glu Tyr Ser Lys Glu Leu 
            100                 105                 110         


Gln Xaa Val Leu Ser Xaa Tyr Leu Arg Pro Leu Gln Xaa Ser Glu Lys 
        115                 120                 125             


Leu Ser Ser Ala Asn Ile Ser Tyr Leu Met Gly Asn Leu Glu Glu Ile 
    130                 135                 140                 


Cys Ser Phe Gln Gln Met Leu Val Gln Ser Leu Glu Glu Cys Xaa Lys 
145                 150                 155                 160 


Leu Pro Glu Ala Gln Gln Arg Val Gly Gly Cys Phe Leu Asn Leu Met 
                165                 170                 175     


Pro Gln Met Lys Xaa Leu Tyr Leu Xaa Tyr Cys Ala Asn His Pro Ser 
            180                 185                 190         


Ala Val Asn Val Leu Xaa Glu His Ser Glu Glu Leu Gly Glu Phe Met 
        195                 200                 205             


Glu Xaa Lys Gly Ala Ser Ser Pro Gly Ile Leu Val Leu Xaa Xaa Gly 
    210                 215                 220                 


Leu Ser Lys Pro Phe Met Arg Leu Asp Lys Tyr Pro Xaa Leu Leu Lys 
225                 230                 235                 240 


Glu Leu Glu Arg His Met Glu Asp Tyr His Xaa Asp Arg Gln Asp Ile 
                245                 250                 255     


Gln Lys Ser Met Ala Ala Phe Lys Asn Leu Ser Ala Gln Cys Gln Glu 
            260                 265                 270         


Val Arg Lys Arg Lys Glu Leu Glu Leu Gln Ile Leu Xaa Glu Ala Ile 
        275                 280                 285             


Arg Asn Trp Glu Gly Asp Asp Ile Lys Xaa Leu Gly Asn Val Xaa Tyr 
    290                 295                 300                 


Met Ser Gln Val Leu Ile Gln Cys Ala Gly Ser Glu Glu Lys Asn Glu 
305                 310                 315                 320 


Arg Tyr Leu Leu Leu Phe Pro Asn Val Leu Leu Met Leu Ser Ala Ser 
                325                 330                 335     


Pro Arg Met Ser Gly Phe Ile Tyr Gln Gly Lys Leu Pro Xaa Xaa Gly 
            340                 345                 350         


Met Xaa Ile Xaa Lys Leu Glu Asp Ser Glu Asn His Arg Asn Ala Phe 
        355                 360                 365             


Glu Ile Ser Gly Ser Met Ile Glu Arg Ile Leu Val Ser Cys Asn Asn 
    370                 375                 380                 


Gln Gln Asp Leu Gln Glu Trp Val Glu His Leu Gln Lys Gln Xaa Lys 
385                 390                 395                 400 


Val Xaa Ser Val Gly Asn Pro Xaa Ile Lys Pro His Ser Val Pro Ser 
                405                 410                 415     


His Xaa Leu Pro Ser His Pro Val Xaa Pro Ser Ser Lys His Ala Asp 
            420                 425                 430         


Ser Lys Pro Ala Pro Leu Xaa Pro Ala Tyr His Xaa Leu Pro His 
        435                 440                 445         


<210> 3065
<211> 625
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<400> 3065
Met Xaa Asp Asn Ser Asn Asn Gln Leu Val Val Arg Ala Lys Phe Asn 
1               5                   10                  15      


Phe Gln Gln Xaa Asn Glu Asp Glu Leu Ser Phe Ser Lys Gly Asp Val 
            20                  25                  30          


Ile His Val Xaa Arg Val Glu Glu Gly Gly Trp Trp Glu Gly Xaa Leu 
        35                  40                  45              


Asn Gly Arg Xaa Gly Trp Phe Pro Ser Asn Tyr Val Arg Glu Val Lys 
    50                  55                  60                  


Ala Ser Glu Lys Pro Val Ser Pro Lys Ser Gly Xaa Leu Lys Ser Pro 
65                  70                  75                  80  


Pro Lys Gly Phe Asp Xaa Xaa Ala Ile Asn Lys Ser Tyr Tyr Asn Val 
                85                  90                  95      


Val Leu Gln Asn Ile Leu Glu Xaa Glu Asn Glu Tyr Ser Lys Glu Leu 
            100                 105                 110         


Gln Xaa Val Leu Ser Xaa Tyr Leu Arg Pro Leu Gln Xaa Ser Glu Lys 
        115                 120                 125             


Leu Ser Ser Ala Asn Ile Ser Tyr Leu Met Gly Asn Leu Glu Glu Ile 
    130                 135                 140                 


Cys Ser Phe Gln Gln Met Leu Val Gln Ser Leu Glu Glu Cys Xaa Lys 
145                 150                 155                 160 


Leu Pro Glu Ala Gln Gln Arg Val Gly Gly Cys Phe Leu Asn Leu Met 
                165                 170                 175     


Pro Gln Met Lys Xaa Leu Tyr Leu Xaa Tyr Cys Ala Asn His Pro Ser 
            180                 185                 190         


Ala Val Asn Val Leu Xaa Glu His Ser Glu Glu Leu Gly Glu Phe Met 
        195                 200                 205             


Glu Xaa Lys Gly Ala Ser Ser Pro Gly Ile Leu Val Leu Xaa Xaa Gly 
    210                 215                 220                 


Leu Ser Lys Pro Phe Met Arg Leu Asp Lys Tyr Pro Xaa Leu Leu Lys 
225                 230                 235                 240 


Glu Leu Glu Arg His Met Glu Asp Tyr His Xaa Asp Arg Gln Asp Ile 
                245                 250                 255     


Gln Lys Ser Met Ala Ala Phe Lys Asn Leu Ser Ala Gln Cys Gln Glu 
            260                 265                 270         


Val Arg Lys Arg Lys Glu Leu Glu Leu Gln Ile Leu Xaa Glu Ala Ile 
        275                 280                 285             


Arg Asn Trp Glu Gly Asp Asp Ile Lys Xaa Leu Gly Asn Val Xaa Tyr 
    290                 295                 300                 


Met Ser Gln Val Leu Ile Gln Cys Ala Gly Ser Glu Glu Lys Asn Glu 
305                 310                 315                 320 


Arg Tyr Leu Leu Leu Phe Pro Asn Val Leu Leu Met Leu Ser Ala Ser 
                325                 330                 335     


Pro Arg Met Ser Gly Phe Ile Tyr Gln Gly Lys Leu Pro Xaa Xaa Gly 
            340                 345                 350         


Met Xaa Ile Xaa Lys Leu Glu Asp Ser Glu Asn His Arg Asn Ala Phe 
        355                 360                 365             


Glu Ile Ser Gly Ser Met Ile Glu Arg Ile Leu Val Ser Cys Asn Asn 
    370                 375                 380                 


Gln Gln Asp Leu Gln Glu Trp Val Glu His Leu Gln Lys Gln Xaa Lys 
385                 390                 395                 400 


Val Xaa Ser Val Gly Asn Pro Xaa Ile Lys Pro His Ser Val Pro Ser 
                405                 410                 415     


His Xaa Leu Pro Ser His Pro Val Xaa Pro Ser Ser Lys His Ala Asp 
            420                 425                 430         


Ser Lys Pro Ala Pro Leu Xaa Pro Ala Tyr His Xaa Leu Pro His Pro 
        435                 440                 445             


Ser His His Gly Xaa Pro His Xaa Xaa Ile Asn Trp Gly Pro Leu Glu 
    450                 455                 460                 


Pro Pro Lys Xaa Pro Lys Pro Trp Ser Leu Ser Cys Leu Arg Pro Ala 
465                 470                 475                 480 


Pro Pro Leu Arg Pro Ser Ala Ala Leu Cys Tyr Lys Glu Asp Leu Ser 
                485                 490                 495     


Lys Ser Pro Lys Xaa Met Lys Lys Leu Leu Pro Lys Arg Lys Pro Glu 
            500                 505                 510         


Arg Lys Pro Ser Asp Glu Glu Phe Ala Ser Arg Lys Ser Xaa Ala Ala 
        515                 520                 525             


Leu Glu Glu Asp Ala Gln Ile Leu Lys Val Ile Glu Ala Tyr Cys Xaa 
    530                 535                 540                 


Ser Ala Lys Xaa Arg Gln Xaa Leu Asn Ser Xaa Trp Gln Gly Xaa Asp 
545                 550                 555                 560 


Leu Met His Asn His Val Leu Ala Asp Asp Asp Gln Pro Ser Leu Asp 
                565                 570                 575     


Ser Leu Gly Arg Arg Ser Ser Leu Ser Arg Leu Glu Pro Ser Asp Leu 
            580                 585                 590         


Ser Glu Asp Ser Asp Tyr Asp Ser Ile Trp Xaa Ala His Ser Tyr Arg 
        595                 600                 605             


Met Gly Ser Xaa Ser Arg Lys Ser Cys Cys Ser Tyr Ile Ser His Gln 
    610                 615                 620                 


Asn 
625 


<210> 3066
<211> 646
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<400> 3066
Met Xaa Asp Asn Ser Asn Asn Gln Leu Val Val Arg Ala Lys Phe Asn 
1               5                   10                  15      


Phe Gln Gln Xaa Asn Glu Asp Glu Leu Ser Phe Ser Lys Gly Asp Val 
            20                  25                  30          


Ile His Val Xaa Arg Val Glu Glu Gly Gly Trp Trp Glu Gly Xaa Leu 
        35                  40                  45              


Asn Gly Arg Xaa Gly Trp Phe Pro Ser Asn Tyr Val Arg Glu Val Lys 
    50                  55                  60                  


Ala Ser Glu Lys Pro Val Ser Pro Lys Ser Gly Xaa Leu Lys Ser Pro 
65                  70                  75                  80  


Pro Lys Gly Phe Asp Xaa Xaa Ala Ile Asn Lys Ser Tyr Tyr Asn Val 
                85                  90                  95      


Val Leu Gln Asn Ile Leu Glu Xaa Glu Asn Glu Tyr Ser Lys Glu Leu 
            100                 105                 110         


Gln Xaa Val Leu Ser Xaa Tyr Leu Arg Pro Leu Gln Xaa Ser Glu Lys 
        115                 120                 125             


Leu Ser Ser Ala Asn Ile Ser Tyr Leu Met Gly Asn Leu Glu Glu Ile 
    130                 135                 140                 


Cys Ser Phe Gln Gln Met Leu Val Gln Ser Leu Glu Glu Cys Xaa Lys 
145                 150                 155                 160 


Leu Pro Glu Ala Gln Gln Arg Val Gly Gly Cys Phe Leu Asn Leu Met 
                165                 170                 175     


Pro Gln Met Lys Xaa Leu Tyr Leu Xaa Tyr Cys Ala Asn His Pro Ser 
            180                 185                 190         


Ala Val Asn Val Leu Xaa Glu His Ser Glu Glu Leu Gly Glu Phe Met 
        195                 200                 205             


Glu Xaa Lys Gly Ala Ser Ser Pro Gly Ile Leu Val Leu Xaa Xaa Gly 
    210                 215                 220                 


Leu Ser Lys Pro Phe Met Arg Leu Asp Lys Tyr Pro Xaa Leu Leu Lys 
225                 230                 235                 240 


Glu Leu Glu Arg His Met Glu Asp Tyr His Xaa Asp Arg Gln Asp Ile 
                245                 250                 255     


Gln Lys Ser Met Ala Ala Phe Lys Asn Leu Ser Ala Gln Cys Gln Glu 
            260                 265                 270         


Val Arg Lys Arg Lys Glu Leu Glu Leu Gln Ile Leu Xaa Glu Ala Ile 
        275                 280                 285             


Arg Asn Trp Glu Gly Asp Asp Ile Lys Xaa Leu Gly Asn Val Xaa Tyr 
    290                 295                 300                 


Met Ser Gln Val Leu Ile Gln Cys Ala Gly Ser Glu Glu Lys Asn Glu 
305                 310                 315                 320 


Arg Tyr Leu Leu Leu Phe Pro Asn Val Leu Leu Met Leu Ser Ala Ser 
                325                 330                 335     


Pro Arg Met Ser Gly Phe Ile Tyr Gln Gly Lys Leu Pro Xaa Xaa Gly 
            340                 345                 350         


Met Xaa Ile Xaa Lys Leu Glu Asp Ser Glu Asn His Arg Asn Ala Phe 
        355                 360                 365             


Glu Ile Ser Gly Ser Met Ile Glu Arg Ile Leu Val Ser Cys Asn Asn 
    370                 375                 380                 


Gln Gln Asp Leu Gln Glu Trp Val Glu His Leu Gln Lys Gln Xaa Lys 
385                 390                 395                 400 


Val Xaa Ser Val Gly Asn Pro Xaa Ile Lys Pro His Ser Val Pro Ser 
                405                 410                 415     


His Xaa Leu Pro Ser His Pro Val Xaa Pro Ser Ser Lys His Ala Asp 
            420                 425                 430         


Ser Lys Pro Ala Pro Leu Xaa Pro Ala Tyr His Xaa Leu Pro His Pro 
        435                 440                 445             


Ser His His Gly Xaa Pro His Xaa Xaa Ile Asn Trp Gly Pro Leu Glu 
    450                 455                 460                 


Pro Pro Lys Xaa Pro Lys Pro Trp Ser Leu Ser Cys Leu Arg Pro Ala 
465                 470                 475                 480 


Pro Pro Leu Arg Pro Ser Ala Ala Leu Cys Tyr Lys Glu Asp Leu Ser 
                485                 490                 495     


Lys Ser Pro Lys Xaa Met Lys Lys Leu Leu Pro Lys Arg Lys Pro Glu 
            500                 505                 510         


Arg Lys Pro Ser Asp Glu Glu Phe Ala Ser Arg Lys Ser Xaa Ala Ala 
        515                 520                 525             


Leu Glu Glu Asp Ala Gln Ile Leu Lys Val Ile Glu Ala Tyr Cys Xaa 
    530                 535                 540                 


Ser Ala Lys Xaa Arg Gln Xaa Leu Asn Ser Ser Ser Arg Lys Glu Ser 
545                 550                 555                 560 


Ala Pro Gln Val Leu Leu Pro Glu Glu Glu Lys Ile Ile Val Glu Glu 
                565                 570                 575     


Xaa Lys Ser Asn Gly Gln Xaa Val Ile Glu Glu Lys Ser Leu Val Asp 
            580                 585                 590         


Xaa Val Tyr Ala Leu Lys Asp Glu Val Gln Glu Leu Arg Gln Asp Asn 
        595                 600                 605             


Lys Lys Met Lys Lys Ser Leu Glu Glu Glu Gln Arg Ala Arg Lys Asp 
    610                 615                 620                 


Leu Glu Lys Leu Val Arg Lys Val Leu Lys Asn Met Asn Asp Pro Ala 
625                 630                 635                 640 


Trp Asp Glu Xaa Asn Leu 
                645     


<210> 3067
<211> 705
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<400> 3067
Met Xaa Asp Asn Ser Asn Asn Gln Leu Val Val Arg Ala Lys Phe Asn 
1               5                   10                  15      


Phe Gln Gln Xaa Asn Glu Asp Glu Leu Ser Phe Ser Lys Gly Asp Val 
            20                  25                  30          


Ile His Val Xaa Arg Val Glu Glu Gly Gly Trp Trp Glu Gly Xaa Leu 
        35                  40                  45              


Asn Gly Arg Xaa Gly Trp Phe Pro Ser Asn Tyr Val Arg Glu Val Lys 
    50                  55                  60                  


Ala Ser Glu Lys Pro Val Ser Pro Lys Ser Gly Xaa Leu Lys Ser Pro 
65                  70                  75                  80  


Pro Lys Gly Phe Asp Xaa Xaa Ala Ile Asn Lys Ser Tyr Tyr Asn Val 
                85                  90                  95      


Val Leu Gln Asn Ile Leu Glu Xaa Glu Asn Glu Tyr Ser Lys Glu Leu 
            100                 105                 110         


Gln Xaa Val Leu Ser Xaa Tyr Leu Arg Pro Leu Gln Xaa Ser Glu Lys 
        115                 120                 125             


Leu Ser Ser Ala Asn Ile Ser Tyr Leu Met Gly Asn Leu Glu Glu Ile 
    130                 135                 140                 


Cys Ser Phe Gln Gln Met Leu Val Gln Ser Leu Glu Glu Cys Xaa Lys 
145                 150                 155                 160 


Leu Pro Glu Ala Gln Gln Arg Val Gly Gly Cys Phe Leu Asn Leu Met 
                165                 170                 175     


Pro Gln Met Lys Xaa Leu Tyr Leu Xaa Tyr Cys Ala Asn His Pro Ser 
            180                 185                 190         


Ala Val Asn Val Leu Xaa Glu His Ser Glu Glu Leu Gly Glu Phe Met 
        195                 200                 205             


Glu Xaa Lys Gly Ala Ser Ser Pro Gly Ile Leu Val Leu Xaa Xaa Gly 
    210                 215                 220                 


Leu Ser Lys Pro Phe Met Arg Leu Asp Lys Tyr Pro Xaa Leu Leu Lys 
225                 230                 235                 240 


Glu Leu Glu Arg His Met Glu Asp Tyr His Xaa Asp Arg Gln Asp Ile 
                245                 250                 255     


Gln Lys Ser Met Ala Ala Phe Lys Asn Leu Ser Ala Gln Cys Gln Glu 
            260                 265                 270         


Val Arg Lys Arg Lys Glu Leu Glu Leu Gln Ile Leu Xaa Glu Ala Ile 
        275                 280                 285             


Arg Asn Trp Glu Gly Asp Asp Ile Lys Xaa Leu Gly Asn Val Xaa Tyr 
    290                 295                 300                 


Met Ser Gln Val Leu Ile Gln Cys Ala Gly Ser Glu Glu Lys Asn Glu 
305                 310                 315                 320 


Arg Tyr Leu Leu Leu Phe Pro Asn Val Leu Leu Met Leu Ser Ala Ser 
                325                 330                 335     


Pro Arg Met Ser Gly Phe Ile Tyr Gln Gly Lys Leu Pro Xaa Xaa Gly 
            340                 345                 350         


Met Xaa Ile Xaa Lys Leu Glu Asp Ser Glu Asn His Arg Asn Ala Phe 
        355                 360                 365             


Glu Ile Ser Gly Ser Met Ile Glu Arg Ile Leu Val Ser Cys Asn Asn 
    370                 375                 380                 


Gln Gln Asp Leu Gln Glu Trp Val Glu His Leu Gln Lys Gln Xaa Lys 
385                 390                 395                 400 


Val Xaa Ser Val Gly Asn Pro Xaa Ile Lys Pro His Ser Val Pro Ser 
                405                 410                 415     


His Xaa Leu Pro Ser His Pro Val Xaa Pro Ser Ser Lys His Ala Asp 
            420                 425                 430         


Ser Lys Pro Ala Pro Leu Xaa Pro Ala Tyr His Xaa Leu Pro His Pro 
        435                 440                 445             


Ser His His Gly Xaa Pro His Xaa Xaa Ile Asn Trp Gly Pro Leu Glu 
    450                 455                 460                 


Pro Pro Lys Xaa Pro Lys Pro Trp Ser Leu Ser Cys Leu Arg Pro Ala 
465                 470                 475                 480 


Pro Pro Leu Arg Pro Ser Ala Ala Leu Cys Tyr Lys Glu Asp Leu Ser 
                485                 490                 495     


Lys Ser Pro Lys Xaa Met Lys Lys Leu Leu Pro Lys Arg Lys Pro Glu 
            500                 505                 510         


Arg Lys Pro Ser Asp Glu Glu Phe Ala Ser Arg Lys Ser Xaa Ala Ala 
        515                 520                 525             


Leu Glu Glu Asp Ala Gln Ile Leu Lys Val Ile Glu Ala Tyr Cys Xaa 
    530                 535                 540                 


Ser Ala Lys Xaa Arg Gln Xaa Leu Asn Ser Xaa Trp Gln Gly Xaa Asp 
545                 550                 555                 560 


Leu Met His Asn His Val Leu Ala Asp Asp Asp Gln Pro Ser Leu Asp 
                565                 570                 575     


Ser Leu Gly Arg Arg Ser Ser Leu Ser Arg Leu Glu Pro Ser Asp Leu 
            580                 585                 590         


Ser Glu Asp Ser Asp Tyr Asp Ser Ile Trp Xaa Ala His Ser Tyr Arg 
        595                 600                 605             


Met Gly Ser Xaa Ser Arg Ser Arg Lys Glu Ser Ala Pro Gln Val Leu 
    610                 615                 620                 


Leu Pro Glu Glu Glu Lys Ile Ile Val Glu Glu Xaa Lys Ser Asn Gly 
625                 630                 635                 640 


Gln Xaa Val Ile Glu Glu Lys Ser Leu Val Asp Xaa Val Tyr Ala Leu 
                645                 650                 655     


Lys Asp Glu Val Gln Glu Leu Arg Gln Asp Asn Lys Lys Met Lys Lys 
            660                 665                 670         


Ser Leu Glu Glu Glu Gln Arg Ala Arg Lys Asp Leu Glu Lys Leu Val 
        675                 680                 685             


Arg Lys Val Leu Lys Asn Met Asn Asp Pro Ala Trp Asp Glu Xaa Asn 
    690                 695                 700                 


Leu 
705 


<210> 3068
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<400> 3068
Xaa Val Leu Ile Gln Cys Ala Gly Ser Glu Glu Lys Asn Glu Arg Tyr 
1               5                   10                  15      


Leu Leu Leu Phe Pro Asn Val Leu Leu Met Leu Ser Ala Ser Pro Arg 
            20                  25                  30          


Met Ser Gly Phe Ile Tyr Gln Gly Lys Leu Pro Xaa Xaa Gly Met Xaa 
        35                  40                  45              


Ile Xaa Lys Leu Glu Asp Ser Glu Asn His Arg Asn Ala Phe Glu Ile 
    50                  55                  60                  


Ser Gly Ser Met Ile Glu Arg Ile Leu Val Ser Cys Asn Asn Gln Gln 
65                  70                  75                  80  


Asp Leu Gln Glu Trp Val Glu His Leu Gln Lys Gln Xaa Lys Val Xaa 
                85                  90                  95      


Ser Val Gly Asn Pro Xaa Ile Lys Pro His Ser Val Pro Ser His Xaa 
            100                 105                 110         


Val Arg Xaa Trp Cys Phe Ser Ser Phe Gln Xaa Pro Gly Val Ala Ser 
        115                 120                 125             


Arg Gly 
    130 


<210> 3069
<211> 42
<212> PRT
<213> Homo sapiens

<400> 3069
Met Ala Asn Arg Glu Leu Ala Phe Lys Ala Gly Asp Val Ile Lys Val 
1               5                   10                  15      


Leu Asp Ala Ser Asn Lys Asp Trp Trp Trp Gly Gln Ile Asp Asp Glu 
            20                  25                  30          


Glu Gly Trp Phe Pro Ala Ser Phe Val Arg 
        35                  40          


<210> 3070
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<400> 3070
Met Ala Asn Arg Glu Leu Ala Phe Lys Ala Gly Asp Val Ile Lys Val 
1               5                   10                  15      


Leu Asp Ala Ser Asn Lys Asp Trp Trp Trp Gly Gln Ile Asp Asp Glu 
            20                  25                  30          


Glu Gly Trp Phe Pro Ala Ser Phe Val Arg Leu Trp Val Asn Gln Glu 
        35                  40                  45              


Asp Glu Val Glu Glu Gly Pro Ser Asp Val Gln Asn Gly His Leu Asp 
    50                  55                  60                  


Pro Asn Ser Asp Cys Leu Cys Leu Gly Arg Pro Leu Gln Asn Arg Asp 
65                  70                  75                  80  


Gln Met Arg Ala Asn Val Ile Asn Glu Ile Met Ser Xaa Glu Arg His 
                85                  90                  95      


Tyr Ile Lys His Leu Lys Asp Ile Cys Glu Gly Tyr Leu Lys Gln Cys 
            100                 105                 110         


Arg Lys Arg 
        115 


<210> 3071
<211> 134
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<400> 3071
Met Ala Asn Arg Glu Leu Ala Phe Lys Ala Gly Asp Val Ile Lys Val 
1               5                   10                  15      


Leu Asp Ala Ser Asn Lys Asp Trp Trp Trp Gly Gln Ile Asp Asp Glu 
            20                  25                  30          


Glu Gly Trp Phe Pro Ala Ser Phe Val Arg Leu Trp Val Asn Gln Glu 
        35                  40                  45              


Asp Glu Val Glu Glu Gly Pro Ser Asp Val Gln Asn Gly His Leu Asp 
    50                  55                  60                  


Pro Asn Ser Asp Cys Leu Cys Leu Gly Arg Pro Leu Gln Asn Arg Asp 
65                  70                  75                  80  


Gln Met Arg Ala Asn Val Ile Asn Glu Ile Met Ser Xaa Glu Arg His 
                85                  90                  95      


Tyr Ile Lys His Leu Lys Asp Ile Cys Glu Gly Tyr Leu Lys Gln Cys 
            100                 105                 110         


Arg Lys Arg Arg Asp Met Phe Ser Asp Glu Gln Leu Lys Val Ile Phe 
        115                 120                 125             


Gly Asn Ile Glu Asp Ile 
    130                 


<210> 3072
<211> 455
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<400> 3072
Met Ala Asn Arg Glu Leu Ala Phe Lys Ala Gly Asp Val Ile Lys Val 
1               5                   10                  15      


Leu Asp Ala Ser Asn Lys Asp Trp Trp Trp Gly Gln Ile Asp Asp Glu 
            20                  25                  30          


Glu Gly Trp Phe Pro Ala Ser Phe Val Arg Leu Trp Val Asn Gln Glu 
        35                  40                  45              


Asp Glu Val Glu Glu Gly Pro Ser Asp Val Gln Asn Gly His Leu Asp 
    50                  55                  60                  


Pro Asn Ser Asp Cys Leu Cys Leu Gly Arg Pro Leu Gln Asn Arg Asp 
65                  70                  75                  80  


Gln Met Arg Ala Asn Val Ile Asn Glu Ile Met Ser Xaa Glu Arg His 
                85                  90                  95      


Tyr Ile Lys His Leu Lys Asp Ile Cys Glu Gly Tyr Leu Lys Gln Cys 
            100                 105                 110         


Arg Lys Arg Arg Asp Met Phe Ser Asp Glu Gln Leu Lys Val Ile Phe 
        115                 120                 125             


Gly Asn Ile Glu Asp Ile Tyr Arg Phe Gln Met Gly Phe Val Arg Asp 
    130                 135                 140                 


Leu Glu Lys Gln Tyr Asn Asn Asp Asp Pro His Leu Ser Glu Ile Gly 
145                 150                 155                 160 


Pro Cys Phe Leu Glu His Gln Asp Gly Phe Trp Ile Tyr Ser Glu Tyr 
                165                 170                 175     


Cys Asn Asn His Leu Asp Ala Cys Met Glu Leu Ser Lys Leu Met Lys 
            180                 185                 190         


Asp Ser Arg Tyr Gln His Phe Phe Glu Ala Cys Arg Leu Leu Gln Gln 
        195                 200                 205             


Met Ile Asp Ile Ala Ile Asp Gly Phe Leu Leu Xaa Pro Val Gln Lys 
    210                 215                 220                 


Ile Cys Lys Tyr Pro Leu Gln Leu Ala Glu Leu Leu Lys Tyr Xaa Ala 
225                 230                 235                 240 


Gln Asp His Ser Asp Tyr Arg Tyr Val Ala Ala Ala Leu Ala Val Met 
                245                 250                 255     


Arg Asn Val Xaa Gln Gln Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn 
            260                 265                 270         


Ile Asp Lys Ile Ala Gln Trp Gln Ala Ser Val Leu Asp Trp Glu Gly 
        275                 280                 285             


Glu Asp Ile Leu Asp Arg Ser Ser Glu Leu Ile Tyr Xaa Gly Glu Met 
    290                 295                 300                 


Ala Trp Ile Tyr Gln Pro Tyr Gly Arg Asn Gln Gln Arg Val Phe Phe 
305                 310                 315                 320 


Leu Phe Asp His Gln Met Val Leu Cys Lys Lys Asp Leu Ile Arg Arg 
                325                 330                 335     


Asp Ile Leu Tyr Tyr Lys Gly Arg Ile Asp Met Asp Lys Tyr Glu Val 
            340                 345                 350         


Val Asp Ile Glu Asp Gly Arg Asp Asp Asp Phe Asn Val Ser Met Lys 
        355                 360                 365             


Asn Ala Phe Lys Leu His Asn Lys Glu Xaa Glu Glu Ile His Leu Phe 
    370                 375                 380                 


Phe Ala Lys Lys Leu Glu Glu Lys Ile Arg Trp Leu Arg Ala Phe Arg 
385                 390                 395                 400 


Glu Glu Arg Lys Met Val Gln Glu Asp Glu Lys Ile Gly Phe Glu Ile 
                405                 410                 415     


Ser Glu Asn Gln Lys Arg Gln Ala Ala Met Xaa Val Arg Lys Val Pro 
            420                 425                 430         


Lys Gln Lys Gly Pro Xaa Ile Gly His Leu Gln Ala Glu Glu Gln Gly 
        435                 440                 445             


Ser Gln Ser Glu Ser Gln Ser 
    450                 455 


<210> 3073
<211> 495
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<400> 3073
Met Ala Asn Arg Glu Leu Ala Phe Lys Ala Gly Asp Val Ile Lys Val 
1               5                   10                  15      


Leu Asp Ala Ser Asn Lys Asp Trp Trp Trp Gly Gln Ile Asp Asp Glu 
            20                  25                  30          


Glu Gly Trp Phe Pro Ala Ser Phe Val Arg Leu Trp Val Asn Gln Glu 
        35                  40                  45              


Asp Glu Val Glu Glu Gly Pro Ser Asp Val Gln Asn Gly His Leu Asp 
    50                  55                  60                  


Pro Asn Ser Asp Cys Leu Cys Leu Gly Arg Pro Leu Gln Asn Arg Asp 
65                  70                  75                  80  


Gln Met Arg Ala Asn Val Ile Asn Glu Ile Met Ser Xaa Glu Arg His 
                85                  90                  95      


Tyr Ile Lys His Leu Lys Asp Ile Cys Glu Gly Tyr Leu Lys Gln Cys 
            100                 105                 110         


Arg Lys Arg Arg Asp Met Phe Ser Asp Glu Gln Leu Lys Val Ile Phe 
        115                 120                 125             


Gly Asn Ile Glu Asp Ile Tyr Arg Phe Gln Met Gly Phe Val Arg Asp 
    130                 135                 140                 


Leu Glu Lys Gln Tyr Asn Asn Asp Asp Pro His Leu Ser Glu Ile Gly 
145                 150                 155                 160 


Pro Cys Phe Leu Glu His Gln Asp Gly Phe Trp Ile Tyr Ser Glu Tyr 
                165                 170                 175     


Cys Asn Asn His Leu Asp Ala Cys Met Glu Leu Ser Lys Leu Met Lys 
            180                 185                 190         


Asp Ser Arg Tyr Gln His Phe Phe Glu Ala Cys Arg Leu Leu Gln Gln 
        195                 200                 205             


Met Ile Asp Ile Ala Ile Asp Gly Phe Leu Leu Xaa Pro Val Gln Lys 
    210                 215                 220                 


Ile Cys Lys Tyr Pro Leu Gln Leu Ala Glu Leu Leu Lys Tyr Xaa Ala 
225                 230                 235                 240 


Gln Asp His Ser Asp Tyr Arg Tyr Val Ala Ala Ala Leu Ala Val Met 
                245                 250                 255     


Arg Asn Val Xaa Gln Gln Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn 
            260                 265                 270         


Ile Asp Lys Ile Ala Gln Trp Gln Ala Ser Val Leu Asp Trp Glu Gly 
        275                 280                 285             


Glu Asp Ile Leu Asp Arg Ser Ser Glu Leu Ile Tyr Xaa Gly Glu Met 
    290                 295                 300                 


Ala Trp Ile Tyr Gln Pro Tyr Gly Arg Asn Gln Gln Arg Val Phe Phe 
305                 310                 315                 320 


Leu Phe Asp His Gln Met Val Leu Cys Lys Lys Asp Leu Ile Arg Arg 
                325                 330                 335     


Asp Ile Leu Tyr Tyr Lys Gly Arg Ile Asp Met Asp Lys Tyr Glu Val 
            340                 345                 350         


Val Asp Ile Glu Asp Gly Arg Asp Asp Asp Phe Asn Val Ser Met Lys 
        355                 360                 365             


Asn Ala Phe Lys Leu His Asn Lys Glu Xaa Glu Glu Ile His Leu Phe 
    370                 375                 380                 


Phe Ala Lys Lys Leu Glu Glu Lys Ile Arg Trp Leu Arg Ala Phe Arg 
385                 390                 395                 400 


Glu Glu Arg Lys Met Val Gln Glu Asp Glu Lys Ile Gly Phe Glu Ile 
                405                 410                 415     


Ser Glu Asn Gln Lys Arg Gln Ala Ala Met Xaa Val Arg Lys Val Pro 
            420                 425                 430         


Lys Gln Lys Gly Val Asn Ser Ala Arg Ser Val Pro Pro Ser Tyr Pro 
        435                 440                 445             


Pro Pro Gln Asp Pro Leu Asn His Gly Gln Tyr Leu Val Pro Asp Gly 
    450                 455                 460                 


Ile Ala Gln Ser Gln Val Phe Glu Phe Xaa Glu Pro Lys Arg Ser Gln 
465                 470                 475                 480 


Ser Pro Phe Trp Gln Asn Phe Ser Arg Leu Xaa Pro Phe Lys Lys 
                485                 490                 495 


<210> 3074
<211> 506
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<400> 3074
Met Ala Asn Arg Glu Leu Ala Phe Lys Ala Gly Asp Val Ile Lys Val 
1               5                   10                  15      


Leu Asp Ala Ser Asn Lys Asp Trp Trp Trp Gly Gln Ile Asp Asp Glu 
            20                  25                  30          


Glu Gly Trp Phe Pro Ala Ser Phe Val Arg Leu Trp Val Asn Gln Glu 
        35                  40                  45              


Asp Glu Val Glu Glu Gly Pro Ser Asp Val Gln Asn Gly His Leu Asp 
    50                  55                  60                  


Pro Asn Ser Asp Cys Leu Cys Leu Gly Arg Pro Leu Gln Asn Arg Asp 
65                  70                  75                  80  


Gln Met Arg Ala Asn Val Ile Asn Glu Ile Met Ser Xaa Glu Arg His 
                85                  90                  95      


Tyr Ile Lys His Leu Lys Asp Ile Cys Glu Gly Tyr Leu Lys Gln Cys 
            100                 105                 110         


Arg Lys Arg Arg Asp Met Phe Ser Asp Glu Gln Leu Lys Val Ile Phe 
        115                 120                 125             


Gly Asn Ile Glu Asp Ile Tyr Arg Phe Gln Met Gly Phe Val Arg Asp 
    130                 135                 140                 


Leu Glu Lys Gln Tyr Asn Asn Asp Asp Pro His Leu Ser Glu Ile Gly 
145                 150                 155                 160 


Pro Cys Phe Leu Glu His Gln Asp Gly Phe Trp Ile Tyr Ser Glu Tyr 
                165                 170                 175     


Cys Asn Asn His Leu Asp Ala Cys Met Glu Leu Ser Lys Leu Met Lys 
            180                 185                 190         


Asp Ser Arg Tyr Gln His Phe Phe Glu Ala Cys Arg Leu Leu Gln Gln 
        195                 200                 205             


Met Ile Asp Ile Ala Ile Asp Gly Phe Leu Leu Xaa Pro Val Gln Lys 
    210                 215                 220                 


Ile Cys Lys Tyr Pro Leu Gln Leu Ala Glu Leu Leu Lys Tyr Xaa Ala 
225                 230                 235                 240 


Gln Asp His Ser Asp Tyr Arg Tyr Val Ala Ala Ala Leu Ala Val Met 
                245                 250                 255     


Arg Asn Val Xaa Gln Gln Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn 
            260                 265                 270         


Ile Asp Lys Ile Ala Gln Trp Gln Ala Ser Val Leu Asp Trp Glu Gly 
        275                 280                 285             


Glu Asp Ile Leu Asp Arg Ser Ser Glu Leu Ile Tyr Xaa Gly Glu Met 
    290                 295                 300                 


Ala Trp Ile Tyr Gln Pro Tyr Gly Arg Asn Gln Gln Arg Val Phe Phe 
305                 310                 315                 320 


Leu Phe Asp His Gln Met Val Leu Cys Lys Lys Asp Leu Ile Arg Arg 
                325                 330                 335     


Asp Ile Leu Tyr Tyr Lys Gly Arg Ile Asp Met Asp Lys Tyr Glu Val 
            340                 345                 350         


Val Asp Ile Glu Asp Gly Arg Asp Asp Asp Phe Asn Val Ser Met Lys 
        355                 360                 365             


Asn Ala Phe Lys Leu His Asn Lys Glu Xaa Glu Glu Ile His Leu Phe 
    370                 375                 380                 


Phe Ala Lys Lys Leu Glu Glu Lys Ile Arg Trp Leu Arg Ala Phe Arg 
385                 390                 395                 400 


Glu Glu Arg Lys Met Val Gln Glu Asp Glu Lys Ile Gly Phe Glu Ile 
                405                 410                 415     


Ser Glu Asn Gln Lys Arg Gln Ala Ala Met Xaa Val Arg Lys Val Pro 
            420                 425                 430         


Lys Gln Lys Gly Val Asn Ser Ala Arg Ser Val Pro Pro Ser Tyr Pro 
        435                 440                 445             


Pro Pro Gln Asp Pro Leu Asn His Gly Gln Tyr Leu Val Pro Asp Gly 
    450                 455                 460                 


Ile Ala Gln Ser Gln Val Phe Glu Phe Xaa Glu Pro Lys Arg Ser Gln 
465                 470                 475                 480 


Ser Pro Phe Trp Gln Asn Phe Ser Arg Cys Leu Gly Ser Ile Asp Arg 
                485                 490                 495     


Ser Met Glu Gly Phe Lys Xaa Glu Pro Xaa 
            500                 505     


<210> 3075
<211> 64
<212> PRT
<213> Homo sapiens

<400> 3075
Met Ala Asn Arg Glu Leu Ala Phe Lys Ala Gly Asp Val Ile Lys Val 
1               5                   10                  15      


Leu Asp Ala Ser Asn Lys Asp Trp Trp Trp Gly Gln Ile Asp Asp Glu 
            20                  25                  30          


Glu Gly Trp Phe Pro Ala Ser Phe Val Arg Ser Glu Ser Ala Asn Ala 
        35                  40                  45              


Ile Cys Val Pro Ser His Leu Cys Trp Leu Lys Asn Gln Ser Gln Gly 
    50                  55                  60                  


<210> 3076
<211> 489
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<400> 3076
Met His Ser Tyr Asn Ile Val Lys Asn Lys Val Ile Ile Ser Trp His 
1               5                   10                  15      


Gln Gln Ala Xaa Pro Gly Met Trp Ala Xaa Val Xaa Ser Ala Xaa Gly 
            20                  25                  30          


Glu Trp Gly Met Leu Trp Val Asn Gln Glu Asp Glu Val Glu Glu Gly 
        35                  40                  45              


Pro Ser Asp Val Gln Asn Gly His Leu Asp Pro Asn Ser Asp Cys Leu 
    50                  55                  60                  


Cys Leu Gly Arg Pro Leu Gln Asn Arg Asp Gln Met Arg Ala Asn Val 
65                  70                  75                  80  


Ile Asn Glu Ile Met Ser Xaa Glu Arg His Tyr Ile Lys His Leu Lys 
                85                  90                  95      


Asp Ile Cys Glu Gly Tyr Leu Lys Gln Cys Arg Lys Arg Arg Asp Met 
            100                 105                 110         


Phe Ser Asp Glu Gln Leu Lys Val Ile Phe Gly Asn Ile Glu Asp Ile 
        115                 120                 125             


Tyr Arg Phe Gln Met Gly Phe Val Arg Asp Leu Glu Lys Gln Tyr Asn 
    130                 135                 140                 


Asn Asp Asp Pro His Leu Ser Glu Ile Gly Pro Cys Phe Leu Glu His 
145                 150                 155                 160 


Gln Asp Gly Phe Trp Ile Tyr Ser Glu Tyr Cys Asn Asn His Leu Asp 
                165                 170                 175     


Ala Cys Met Glu Leu Ser Lys Leu Met Lys Asp Ser Arg Tyr Gln His 
            180                 185                 190         


Phe Phe Glu Ala Cys Arg Leu Leu Gln Gln Met Ile Asp Ile Ala Ile 
        195                 200                 205             


Asp Gly Phe Leu Leu Xaa Pro Val Gln Lys Ile Cys Lys Tyr Pro Leu 
    210                 215                 220                 


Gln Leu Ala Glu Leu Leu Lys Tyr Xaa Ala Gln Asp His Ser Asp Tyr 
225                 230                 235                 240 


Arg Tyr Val Ala Ala Ala Leu Ala Val Met Arg Asn Val Xaa Gln Gln 
                245                 250                 255     


Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn Ile Asp Lys Ile Ala Gln 
            260                 265                 270         


Trp Gln Ala Ser Val Leu Asp Trp Glu Gly Glu Asp Ile Leu Asp Arg 
        275                 280                 285             


Ser Ser Glu Leu Ile Tyr Xaa Gly Glu Met Ala Trp Ile Tyr Gln Pro 
    290                 295                 300                 


Tyr Gly Arg Asn Gln Gln Arg Val Phe Phe Leu Phe Asp His Gln Met 
305                 310                 315                 320 


Val Leu Cys Lys Lys Asp Leu Ile Arg Arg Asp Ile Leu Tyr Tyr Lys 
                325                 330                 335     


Gly Arg Ile Asp Met Asp Lys Tyr Glu Val Val Asp Ile Glu Asp Gly 
            340                 345                 350         


Arg Asp Asp Asp Phe Asn Val Ser Met Lys Asn Ala Phe Lys Leu His 
        355                 360                 365             


Asn Lys Glu Xaa Glu Glu Ile His Leu Phe Phe Ala Lys Lys Leu Glu 
    370                 375                 380                 


Glu Lys Ile Arg Trp Leu Arg Ala Phe Arg Glu Glu Arg Lys Met Val 
385                 390                 395                 400 


Gln Glu Asp Glu Lys Ile Gly Phe Glu Ile Ser Glu Asn Gln Lys Arg 
                405                 410                 415     


Gln Ala Ala Met Xaa Val Arg Lys Val Pro Lys Gln Lys Gly Val Asn 
            420                 425                 430         


Ser Ala Arg Ser Val Pro Pro Ser Tyr Pro Pro Pro Gln Asp Pro Leu 
        435                 440                 445             


Asn His Gly Gln Tyr Leu Val Pro Asp Gly Ile Ala Gln Ser Gln Val 
    450                 455                 460                 


Phe Glu Phe Xaa Glu Pro Lys Arg Ser Gln Ser Pro Phe Trp Gln Asn 
465                 470                 475                 480 


Phe Ser Arg Leu Xaa Pro Phe Lys Lys 
                485                 


<210> 3077
<211> 454
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<400> 3077
Met Leu Trp Val Asn Gln Glu Asp Glu Val Glu Glu Gly Pro Ser Asp 
1               5                   10                  15      


Val Gln Asn Gly His Leu Asp Pro Asn Ser Asp Cys Leu Cys Leu Gly 
            20                  25                  30          


Arg Pro Leu Gln Asn Arg Asp Gln Met Arg Ala Asn Val Ile Asn Glu 
        35                  40                  45              


Ile Met Ser Xaa Glu Arg His Tyr Ile Lys His Leu Lys Asp Ile Cys 
    50                  55                  60                  


Glu Gly Tyr Leu Lys Gln Cys Arg Lys Arg Arg Asp Met Phe Ser Asp 
65                  70                  75                  80  


Glu Gln Leu Lys Val Ile Phe Gly Asn Ile Glu Asp Ile Tyr Arg Phe 
                85                  90                  95      


Gln Met Gly Phe Val Arg Asp Leu Glu Lys Gln Tyr Asn Asn Asp Asp 
            100                 105                 110         


Pro His Leu Ser Glu Ile Gly Pro Cys Phe Leu Glu His Gln Asp Gly 
        115                 120                 125             


Phe Trp Ile Tyr Ser Glu Tyr Cys Asn Asn His Leu Asp Ala Cys Met 
    130                 135                 140                 


Glu Leu Ser Lys Leu Met Lys Asp Ser Arg Tyr Gln His Phe Phe Glu 
145                 150                 155                 160 


Ala Cys Arg Leu Leu Gln Gln Met Ile Asp Ile Ala Ile Asp Gly Phe 
                165                 170                 175     


Leu Leu Xaa Pro Val Gln Lys Ile Cys Lys Tyr Pro Leu Gln Leu Ala 
            180                 185                 190         


Glu Leu Leu Lys Tyr Xaa Ala Gln Asp His Ser Asp Tyr Arg Tyr Val 
        195                 200                 205             


Ala Ala Ala Leu Ala Val Met Arg Asn Val Xaa Gln Gln Ile Asn Glu 
    210                 215                 220                 


Arg Lys Arg Arg Leu Glu Asn Ile Asp Lys Ile Ala Gln Trp Gln Ala 
225                 230                 235                 240 


Ser Val Leu Asp Trp Glu Gly Glu Asp Ile Leu Asp Arg Ser Ser Glu 
                245                 250                 255     


Leu Ile Tyr Xaa Gly Glu Met Ala Trp Ile Tyr Gln Pro Tyr Gly Arg 
            260                 265                 270         


Asn Gln Gln Arg Val Phe Phe Leu Phe Asp His Gln Met Val Leu Cys 
        275                 280                 285             


Lys Lys Asp Leu Ile Arg Arg Asp Ile Leu Tyr Tyr Lys Gly Arg Ile 
    290                 295                 300                 


Asp Met Asp Lys Tyr Glu Val Val Asp Ile Glu Asp Gly Arg Asp Asp 
305                 310                 315                 320 


Asp Phe Asn Val Ser Met Lys Asn Ala Phe Lys Leu His Asn Lys Glu 
                325                 330                 335     


Xaa Glu Glu Ile His Leu Phe Phe Ala Lys Lys Leu Glu Glu Lys Ile 
            340                 345                 350         


Arg Trp Leu Arg Ala Phe Arg Glu Glu Arg Lys Met Val Gln Glu Asp 
        355                 360                 365             


Glu Lys Ile Gly Phe Glu Ile Ser Glu Asn Gln Lys Arg Gln Ala Ala 
    370                 375                 380                 


Met Xaa Val Arg Lys Val Pro Lys Gln Lys Gly Val Asn Ser Ala Arg 
385                 390                 395                 400 


Ser Val Pro Pro Ser Tyr Pro Pro Pro Gln Asp Pro Leu Asn His Gly 
                405                 410                 415     


Gln Tyr Leu Val Pro Asp Gly Ile Ala Gln Ser Gln Val Phe Glu Phe 
            420                 425                 430         


Xaa Glu Pro Lys Arg Ser Gln Ser Pro Phe Trp Gln Asn Phe Ser Arg 
        435                 440                 445             


Leu Xaa Pro Phe Lys Lys 
    450                 


<210> 3078
<211> 483
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<400> 3078
Met Gln Trp Ile Arg Gly Gly Ser Gly Met Leu Ile Xaa Gly Asp Ser 
1               5                   10                  15      


Ile Val Ser Ala Glu Ala Val Trp Asp His Val Xaa Met Ala Asn Arg 
            20                  25                  30          


Glu Leu Ala Phe Lys Ala Gly Asp Val Ile Lys Val Leu Asp Ala Ser 
        35                  40                  45              


Asn Lys Asp Trp Trp Trp Gly Gln Ile Asp Asp Glu Glu Gly Trp Phe 
    50                  55                  60                  


Pro Ala Ser Phe Val Arg Leu Trp Val Asn Gln Glu Asp Glu Val Glu 
65                  70                  75                  80  


Glu Gly Pro Ser Asp Val Gln Asn Gly His Leu Asp Pro Asn Ser Asp 
                85                  90                  95      


Cys Leu Cys Leu Gly Arg Pro Leu Gln Asn Arg Asp Gln Met Arg Ala 
            100                 105                 110         


Asn Val Ile Asn Glu Ile Met Ser Xaa Glu Arg His Tyr Ile Lys His 
        115                 120                 125             


Leu Lys Asp Ile Cys Glu Gly Tyr Leu Lys Gln Cys Arg Lys Arg Arg 
    130                 135                 140                 


Asp Met Phe Ser Asp Glu Gln Leu Lys Val Ile Phe Gly Asn Ile Glu 
145                 150                 155                 160 


Asp Ile Tyr Arg Phe Gln Met Gly Phe Val Arg Asp Leu Glu Lys Gln 
                165                 170                 175     


Tyr Asn Asn Asp Asp Pro His Leu Ser Glu Ile Gly Pro Cys Phe Leu 
            180                 185                 190         


Glu His Gln Asp Gly Phe Trp Ile Tyr Ser Glu Tyr Cys Asn Asn His 
        195                 200                 205             


Leu Asp Ala Cys Met Glu Leu Ser Lys Leu Met Lys Asp Ser Arg Tyr 
    210                 215                 220                 


Gln His Phe Phe Glu Ala Cys Arg Leu Leu Gln Gln Met Ile Asp Ile 
225                 230                 235                 240 


Ala Ile Asp Gly Phe Leu Leu Xaa Pro Val Gln Lys Ile Cys Lys Tyr 
                245                 250                 255     


Pro Leu Gln Leu Ala Glu Leu Leu Lys Tyr Xaa Ala Gln Asp His Ser 
            260                 265                 270         


Asp Tyr Arg Tyr Val Ala Ala Ala Leu Ala Val Met Arg Asn Val Xaa 
        275                 280                 285             


Gln Gln Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn Ile Asp Lys Ile 
    290                 295                 300                 


Ala Gln Trp Gln Ala Ser Val Leu Asp Trp Glu Gly Glu Asp Ile Leu 
305                 310                 315                 320 


Asp Arg Ser Ser Glu Leu Ile Tyr Xaa Gly Glu Met Ala Trp Ile Tyr 
                325                 330                 335     


Gln Pro Tyr Gly Arg Asn Gln Gln Arg Val Phe Phe Leu Phe Asp His 
            340                 345                 350         


Gln Met Val Leu Cys Lys Lys Asp Leu Ile Arg Arg Asp Ile Leu Tyr 
        355                 360                 365             


Tyr Lys Gly Arg Ile Asp Met Asp Lys Tyr Glu Val Val Asp Ile Glu 
    370                 375                 380                 


Asp Gly Arg Asp Asp Asp Phe Asn Val Ser Met Lys Asn Ala Phe Lys 
385                 390                 395                 400 


Leu His Asn Lys Glu Xaa Glu Glu Ile His Leu Phe Phe Ala Lys Lys 
                405                 410                 415     


Leu Glu Glu Lys Ile Arg Trp Leu Arg Ala Phe Arg Glu Glu Arg Lys 
            420                 425                 430         


Met Val Gln Glu Asp Glu Lys Ile Gly Phe Glu Ile Ser Glu Asn Gln 
        435                 440                 445             


Lys Arg Gln Ala Ala Met Xaa Val Arg Lys Val Pro Lys Gln Lys Gly 
    450                 455                 460                 


Gly Xaa Gly Glu Gly Glu Ile Glu Phe Val Gly Phe Phe Ala Gly Pro 
465                 470                 475                 480 


Xaa Pro Ala 
            


<210> 3079
<211> 487
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<400> 3079
Met Gln Trp Ile Arg Gly Gly Ser Gly Met Leu Ile Xaa Gly Asp Ser 
1               5                   10                  15      


Ile Val Ser Ala Glu Ala Val Trp Asp His Val Xaa Met Ala Asn Arg 
            20                  25                  30          


Glu Leu Ala Phe Lys Ala Gly Asp Val Ile Lys Val Leu Asp Ala Ser 
        35                  40                  45              


Asn Lys Asp Trp Trp Trp Gly Gln Ile Asp Asp Glu Glu Gly Trp Phe 
    50                  55                  60                  


Pro Ala Ser Phe Val Arg Leu Trp Val Asn Gln Glu Asp Glu Val Glu 
65                  70                  75                  80  


Glu Gly Pro Ser Asp Val Gln Asn Gly His Leu Asp Pro Asn Ser Asp 
                85                  90                  95      


Cys Leu Cys Leu Gly Arg Pro Leu Gln Asn Arg Asp Gln Met Arg Ala 
            100                 105                 110         


Asn Val Ile Asn Glu Ile Met Ser Xaa Glu Arg His Tyr Ile Lys His 
        115                 120                 125             


Leu Lys Asp Ile Cys Glu Gly Tyr Leu Lys Gln Cys Arg Lys Arg Arg 
    130                 135                 140                 


Asp Met Phe Ser Asp Glu Gln Leu Lys Val Ile Phe Gly Asn Ile Glu 
145                 150                 155                 160 


Asp Ile Tyr Arg Phe Gln Met Gly Phe Val Arg Asp Leu Glu Lys Gln 
                165                 170                 175     


Tyr Asn Asn Asp Asp Pro His Leu Ser Glu Ile Gly Pro Cys Phe Leu 
            180                 185                 190         


Glu His Gln Asp Gly Phe Trp Ile Tyr Ser Glu Tyr Cys Asn Asn His 
        195                 200                 205             


Leu Asp Ala Cys Met Glu Leu Ser Lys Leu Met Lys Asp Ser Arg Tyr 
    210                 215                 220                 


Gln His Phe Phe Glu Ala Cys Arg Leu Leu Gln Gln Met Ile Asp Ile 
225                 230                 235                 240 


Ala Ile Asp Gly Phe Leu Leu Xaa Pro Val Gln Lys Ile Cys Lys Tyr 
                245                 250                 255     


Pro Leu Gln Leu Ala Glu Leu Leu Lys Tyr Xaa Ala Gln Asp His Ser 
            260                 265                 270         


Asp Tyr Arg Tyr Val Ala Ala Ala Leu Ala Val Met Arg Asn Val Xaa 
        275                 280                 285             


Gln Gln Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn Ile Asp Lys Ile 
    290                 295                 300                 


Ala Gln Trp Gln Ala Ser Val Leu Asp Trp Glu Gly Glu Asp Ile Leu 
305                 310                 315                 320 


Asp Arg Ser Ser Glu Leu Ile Tyr Xaa Gly Glu Met Ala Trp Ile Tyr 
                325                 330                 335     


Gln Pro Tyr Gly Arg Asn Gln Gln Arg Val Phe Phe Leu Phe Asp His 
            340                 345                 350         


Gln Met Val Leu Cys Lys Lys Asp Leu Ile Arg Arg Asp Ile Leu Tyr 
        355                 360                 365             


Tyr Lys Gly Arg Ile Asp Met Asp Lys Tyr Glu Val Val Asp Ile Glu 
    370                 375                 380                 


Asp Gly Arg Asp Asp Asp Phe Asn Val Ser Met Lys Asn Ala Phe Lys 
385                 390                 395                 400 


Leu His Asn Lys Glu Xaa Glu Glu Ile His Leu Phe Phe Ala Lys Lys 
                405                 410                 415     


Leu Glu Glu Lys Ile Arg Trp Leu Arg Ala Phe Arg Glu Glu Arg Lys 
            420                 425                 430         


Met Val Gln Glu Asp Glu Lys Ile Gly Phe Glu Ile Ser Glu Asn Gln 
        435                 440                 445             


Lys Arg Gln Ala Ala Met Xaa Val Arg Lys Leu Pro Phe Pro Gln Leu 
    450                 455                 460                 


Ser Glu Ala Arg Ile Cys Ser Pro Lys Gly Phe Ala Ser Val Phe Asn 
465                 470                 475                 480 


Gly Xaa Cys Cys Gly Glu Ser 
                485         


<210> 3080
<211> 463
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<400> 3080
Met Gln Trp Ile Arg Gly Gly Ser Gly Met Leu Trp Val Asn Gln Glu 
1               5                   10                  15      


Asp Glu Val Glu Glu Gly Pro Ser Asp Val Gln Asn Gly His Leu Asp 
            20                  25                  30          


Pro Asn Ser Asp Cys Leu Cys Leu Gly Arg Pro Leu Gln Asn Arg Asp 
        35                  40                  45              


Gln Met Arg Ala Asn Val Ile Asn Glu Ile Met Ser Xaa Glu Arg His 
    50                  55                  60                  


Tyr Ile Lys His Leu Lys Asp Ile Cys Glu Gly Tyr Leu Lys Gln Cys 
65                  70                  75                  80  


Arg Lys Arg Arg Asp Met Phe Ser Asp Glu Gln Leu Lys Val Ile Phe 
                85                  90                  95      


Gly Asn Ile Glu Asp Ile Tyr Arg Phe Gln Met Gly Phe Val Arg Asp 
            100                 105                 110         


Leu Glu Lys Gln Tyr Asn Asn Asp Asp Pro His Leu Ser Glu Ile Gly 
        115                 120                 125             


Pro Cys Phe Leu Glu His Gln Asp Gly Phe Trp Ile Tyr Ser Glu Tyr 
    130                 135                 140                 


Cys Asn Asn His Leu Asp Ala Cys Met Glu Leu Ser Lys Leu Met Lys 
145                 150                 155                 160 


Asp Ser Arg Tyr Gln His Phe Phe Glu Ala Cys Arg Leu Leu Gln Gln 
                165                 170                 175     


Met Ile Asp Ile Ala Ile Asp Gly Phe Leu Leu Xaa Pro Val Gln Lys 
            180                 185                 190         


Ile Cys Lys Tyr Pro Leu Gln Leu Ala Glu Leu Leu Lys Tyr Xaa Ala 
        195                 200                 205             


Gln Asp His Ser Asp Tyr Arg Tyr Val Ala Ala Ala Leu Ala Val Met 
    210                 215                 220                 


Arg Asn Val Xaa Gln Gln Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Ile Asp Lys Ile Ala Gln Trp Gln Ala Ser Val Leu Asp Trp Glu Gly 
                245                 250                 255     


Glu Asp Ile Leu Asp Arg Ser Ser Glu Leu Ile Tyr Xaa Gly Glu Met 
            260                 265                 270         


Ala Trp Ile Tyr Gln Pro Tyr Gly Arg Asn Gln Gln Arg Val Phe Phe 
        275                 280                 285             


Leu Phe Asp His Gln Met Val Leu Cys Lys Lys Asp Leu Ile Arg Arg 
    290                 295                 300                 


Asp Ile Leu Tyr Tyr Lys Gly Arg Ile Asp Met Asp Lys Tyr Glu Val 
305                 310                 315                 320 


Val Asp Ile Glu Asp Gly Arg Asp Asp Asp Phe Asn Val Ser Met Lys 
                325                 330                 335     


Asn Ala Phe Lys Leu His Asn Lys Glu Xaa Glu Glu Ile His Leu Phe 
            340                 345                 350         


Phe Ala Lys Lys Leu Glu Glu Lys Ile Arg Trp Leu Arg Ala Phe Arg 
        355                 360                 365             


Glu Glu Arg Lys Met Val Gln Glu Asp Glu Lys Ile Gly Phe Glu Ile 
    370                 375                 380                 


Ser Glu Asn Gln Lys Arg Gln Ala Ala Met Xaa Val Arg Lys Val Pro 
385                 390                 395                 400 


Lys Gln Lys Gly Val Asn Ser Ala Arg Ser Val Pro Pro Ser Tyr Pro 
                405                 410                 415     


Pro Pro Gln Asp Pro Leu Asn His Gly Gln Tyr Leu Val Pro Asp Gly 
            420                 425                 430         


Ile Ala Gln Ser Gln Val Phe Glu Phe Xaa Glu Pro Lys Arg Ser Gln 
        435                 440                 445             


Ser Pro Phe Trp Gln Asn Phe Ser Arg Leu Xaa Pro Phe Lys Lys 
    450                 455                 460             


<210> 3081
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<400> 3081
Met Arg Ala Asn Val Ile Asn Glu Ile Met Ser Xaa Glu Arg His Tyr 
1               5                   10                  15      


Ile Lys His Leu Lys Asp Ile Cys Glu Gly Tyr Leu Lys Gln Cys Arg 
            20                  25                  30          


Lys Arg Arg Asp Met Phe Ser Asp Glu Gln Leu Lys Val Ile Phe Gly 
        35                  40                  45              


Asn Ile Glu Asp Ile Tyr Arg Phe Gln Met Gly Phe Val Arg Asp Leu 
    50                  55                  60                  


Glu Lys Gln Tyr Asn Asn Asp Asp Pro His Leu Ser Glu Ile Gly Pro 
65                  70                  75                  80  


Cys Phe Leu Glu His Gln Asp Gly Phe Trp Ile Tyr Ser Glu Tyr Cys 
                85                  90                  95      


Asn Asn His Leu Asp Ala Cys Met Glu Leu Ser Lys 
            100                 105             


<210> 3082
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<400> 3082
Met Arg Ala Asn Val Ile Asn Glu Ile Met Ser Xaa Glu Arg His Tyr 
1               5                   10                  15      


Ile Lys His Leu Lys Asp Ile Cys Glu Gly Tyr Leu Lys Gln Cys Arg 
            20                  25                  30          


Lys Arg Arg Asp Met Phe Ser Asp Glu Gln Leu Lys Val Ile Phe Gly 
        35                  40                  45              


Asn Ile Glu Asp Ile Tyr Arg Phe Gln Met Gly Phe Val Arg Asp Leu 
    50                  55                  60                  


Glu Lys Gln Tyr Asn Asn Asp Asp Pro His Leu Ser Glu Ile Gly Pro 
65                  70                  75                  80  


Cys Phe Leu Glu His Gln Asp Gly Phe Trp Ile Tyr Ser Glu Tyr Cys 
                85                  90                  95      


Asn Asn His Leu Asp Ala Cys Met Glu Leu Ser Lys Leu Met 
            100                 105                 110 


<210> 3083
<211> 414
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<400> 3083
Met Arg Ala Asn Val Ile Asn Glu Ile Met Ser Xaa Glu Arg His Tyr 
1               5                   10                  15      


Ile Lys His Leu Lys Asp Ile Cys Glu Gly Tyr Leu Lys Gln Cys Arg 
            20                  25                  30          


Lys Arg Arg Asp Met Phe Ser Asp Glu Gln Leu Lys Val Ile Phe Gly 
        35                  40                  45              


Asn Ile Glu Asp Ile Tyr Arg Phe Gln Met Gly Phe Val Arg Asp Leu 
    50                  55                  60                  


Glu Lys Gln Tyr Asn Asn Asp Asp Pro His Leu Ser Glu Ile Gly Pro 
65                  70                  75                  80  


Cys Phe Leu Glu His Gln Asp Gly Phe Trp Ile Tyr Ser Glu Tyr Cys 
                85                  90                  95      


Asn Asn His Leu Asp Ala Cys Met Glu Leu Ser Lys Leu Met Lys Asp 
            100                 105                 110         


Ser Arg Tyr Gln His Phe Phe Glu Ala Cys Arg Leu Leu Gln Gln Met 
        115                 120                 125             


Ile Asp Ile Ala Ile Asp Gly Phe Leu Leu Xaa Pro Val Gln Lys Ile 
    130                 135                 140                 


Cys Lys Tyr Pro Leu Gln Leu Ala Glu Leu Leu Lys Tyr Xaa Ala Gln 
145                 150                 155                 160 


Asp His Ser Asp Tyr Arg Tyr Val Ala Ala Ala Leu Ala Val Met Arg 
                165                 170                 175     


Asn Val Xaa Gln Gln Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn Ile 
            180                 185                 190         


Asp Lys Ile Ala Gln Trp Gln Ala Ser Val Leu Asp Trp Glu Gly Glu 
        195                 200                 205             


Asp Ile Leu Asp Arg Ser Ser Glu Leu Ile Tyr Xaa Gly Glu Met Ala 
    210                 215                 220                 


Trp Ile Tyr Gln Pro Tyr Gly Arg Asn Gln Gln Arg Val Phe Phe Leu 
225                 230                 235                 240 


Phe Asp His Gln Met Val Leu Cys Lys Lys Asp Leu Ile Arg Arg Asp 
                245                 250                 255     


Ile Leu Tyr Tyr Lys Gly Arg Ile Asp Met Asp Lys Tyr Glu Val Val 
            260                 265                 270         


Asp Ile Glu Asp Gly Arg Asp Asp Asp Phe Asn Val Ser Met Lys Asn 
        275                 280                 285             


Ala Phe Lys Leu His Asn Lys Glu Xaa Glu Glu Ile His Leu Phe Phe 
    290                 295                 300                 


Ala Lys Lys Leu Glu Glu Lys Ile Arg Trp Leu Arg Ala Phe Arg Glu 
305                 310                 315                 320 


Glu Arg Lys Met Val Gln Glu Asp Glu Lys Ile Gly Phe Glu Ile Ser 
                325                 330                 335     


Glu Asn Gln Lys Arg Gln Ala Ala Met Xaa Val Arg Lys Val Pro Lys 
            340                 345                 350         


Gln Lys Gly Val Asn Ser Ala Arg Ser Val Pro Pro Ser Tyr Pro Pro 
        355                 360                 365             


Pro Gln Asp Pro Leu Asn His Gly Gln Tyr Leu Val Pro Asp Gly Ile 
    370                 375                 380                 


Ala Gln Ser Gln Val Phe Glu Phe Xaa Glu Pro Lys Arg Ser Gln Ser 
385                 390                 395                 400 


Pro Phe Trp Gln Asn Phe Ser Arg Leu Xaa Pro Phe Lys Lys 
                405                 410                 


<210> 3084
<211> 529
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<400> 3084
Met Ser Val Ala Leu Ala Ala Pro His Ala Ser Ala Arg Ser Arg Ser 
1               5                   10                  15      


Leu Ile Xaa Gly Asp Ser Ile Val Ser Ala Glu Ala Val Trp Asp His 
            20                  25                  30          


Val Xaa Met Ala Asn Arg Glu Leu Ala Phe Lys Ala Gly Asp Val Ile 
        35                  40                  45              


Lys Val Leu Asp Ala Ser Asn Lys Asp Trp Trp Trp Gly Gln Ile Asp 
    50                  55                  60                  


Asp Glu Glu Gly Trp Phe Pro Ala Ser Phe Val Arg Leu Trp Val Asn 
65                  70                  75                  80  


Gln Glu Asp Glu Val Glu Glu Gly Pro Ser Asp Val Gln Asn Gly His 
                85                  90                  95      


Leu Asp Pro Asn Ser Asp Cys Leu Cys Leu Gly Arg Pro Leu Gln Asn 
            100                 105                 110         


Arg Asp Gln Met Arg Ala Asn Val Ile Asn Glu Ile Met Ser Xaa Glu 
        115                 120                 125             


Arg His Tyr Ile Lys His Leu Lys Asp Ile Cys Glu Gly Tyr Leu Lys 
    130                 135                 140                 


Gln Cys Arg Lys Arg Arg Asp Met Phe Ser Asp Glu Gln Leu Lys Val 
145                 150                 155                 160 


Ile Phe Gly Asn Ile Glu Asp Ile Tyr Arg Phe Gln Met Gly Phe Val 
                165                 170                 175     


Arg Asp Leu Glu Lys Gln Tyr Asn Asn Asp Asp Pro His Leu Ser Glu 
            180                 185                 190         


Ile Gly Pro Cys Phe Leu Glu His Gln Asp Gly Phe Trp Ile Tyr Ser 
        195                 200                 205             


Glu Tyr Cys Asn Asn His Leu Asp Ala Cys Met Glu Leu Ser Lys Leu 
    210                 215                 220                 


Met Lys Asp Ser Arg Tyr Gln His Phe Phe Glu Ala Cys Arg Leu Leu 
225                 230                 235                 240 


Gln Gln Met Ile Asp Ile Ala Ile Asp Gly Phe Leu Leu Xaa Pro Val 
                245                 250                 255     


Gln Lys Ile Cys Lys Tyr Pro Leu Gln Leu Ala Glu Leu Leu Lys Tyr 
            260                 265                 270         


Xaa Ala Gln Asp His Ser Asp Tyr Arg Tyr Val Ala Ala Ala Leu Ala 
        275                 280                 285             


Val Met Arg Asn Val Xaa Gln Gln Ile Asn Glu Arg Lys Arg Arg Leu 
    290                 295                 300                 


Glu Asn Ile Asp Lys Ile Ala Gln Trp Gln Ala Ser Val Leu Asp Trp 
305                 310                 315                 320 


Glu Gly Glu Asp Ile Leu Asp Arg Ser Ser Glu Leu Ile Tyr Xaa Gly 
                325                 330                 335     


Glu Met Ala Trp Ile Tyr Gln Pro Tyr Gly Arg Asn Gln Gln Arg Val 
            340                 345                 350         


Phe Phe Leu Phe Asp His Gln Met Val Leu Cys Lys Lys Asp Leu Ile 
        355                 360                 365             


Arg Arg Asp Ile Leu Tyr Tyr Lys Gly Arg Ile Asp Met Asp Lys Tyr 
    370                 375                 380                 


Glu Val Val Asp Ile Glu Asp Gly Arg Asp Asp Asp Phe Asn Val Ser 
385                 390                 395                 400 


Met Lys Asn Ala Phe Lys Leu His Asn Lys Glu Xaa Glu Glu Ile His 
                405                 410                 415     


Leu Phe Phe Ala Lys Lys Leu Glu Glu Lys Ile Arg Trp Leu Arg Ala 
            420                 425                 430         


Phe Arg Glu Glu Arg Lys Met Val Gln Glu Asp Glu Lys Ile Gly Phe 
        435                 440                 445             


Glu Ile Ser Glu Asn Gln Lys Arg Gln Ala Ala Met Xaa Val Arg Lys 
    450                 455                 460                 


Val Pro Lys Gln Lys Gly Val Asn Ser Ala Arg Ser Val Pro Pro Ser 
465                 470                 475                 480 


Tyr Pro Pro Pro Gln Asp Pro Leu Asn His Gly Gln Tyr Leu Val Pro 
                485                 490                 495     


Asp Gly Ile Ala Gln Ser Gln Val Phe Glu Phe Xaa Glu Pro Lys Arg 
            500                 505                 510         


Ser Gln Ser Pro Phe Trp Gln Asn Phe Ser Arg Leu Xaa Pro Phe Lys 
        515                 520                 525             


Lys 
    


<210> 3085
<211> 458
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<400> 3085
Met Xaa Leu Leu Ile Xaa Gly Asp Ser Ile Val Ser Ala Glu Ala Val 
1               5                   10                  15      


Trp Asp His Val Xaa Met Ala Asn Arg Glu Leu Ala Phe Lys Ala Gly 
            20                  25                  30          


Asp Val Ile Lys Val Leu Asp Ala Ser Asn Lys Asp Trp Trp Trp Gly 
        35                  40                  45              


Gln Ile Asp Asp Glu Glu Gly Trp Phe Pro Ala Ser Phe Val Arg Leu 
    50                  55                  60                  


Trp Val Asn Gln Glu Asp Glu Val Glu Glu Gly Pro Ser Asp Val Gln 
65                  70                  75                  80  


Asn Gly His Leu Asp Pro Asn Ser Asp Cys Leu Cys Leu Gly Arg Pro 
                85                  90                  95      


Leu Gln Asn Arg Asp Gln Met Arg Ala Asn Val Ile Asn Glu Ile Met 
            100                 105                 110         


Ser Xaa Glu Arg His Tyr Ile Lys His Leu Lys Asp Ile Cys Glu Gly 
        115                 120                 125             


Tyr Leu Lys Gln Cys Arg Lys Arg Arg Asp Met Phe Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Val Ile Phe Gly Asn Ile Glu Asp Ile Tyr Arg Phe Gln Met 
145                 150                 155                 160 


Gly Phe Val Arg Asp Leu Glu Lys Gln Tyr Asn Asn Asp Asp Pro His 
                165                 170                 175     


Leu Ser Glu Ile Gly Pro Cys Phe Leu Glu His Gln Asp Gly Phe Trp 
            180                 185                 190         


Ile Tyr Ser Glu Tyr Cys Asn Asn His Leu Asp Ala Cys Met Glu Leu 
        195                 200                 205             


Ser Lys Leu Met Lys Asp Ser Arg Tyr Gln His Phe Phe Glu Ala Cys 
    210                 215                 220                 


Arg Leu Leu Gln Gln Met Ile Asp Ile Ala Ile Asp Gly Phe Leu Leu 
225                 230                 235                 240 


Xaa Pro Val Gln Lys Ile Cys Lys Tyr Pro Leu Gln Leu Ala Glu Leu 
                245                 250                 255     


Leu Lys Tyr Xaa Ala Gln Asp His Ser Asp Tyr Arg Tyr Val Ala Ala 
            260                 265                 270         


Ala Leu Ala Val Met Arg Asn Val Xaa Gln Gln Ile Asn Glu Arg Lys 
        275                 280                 285             


Arg Arg Leu Glu Asn Ile Asp Lys Ile Ala Gln Trp Gln Ala Ser Val 
    290                 295                 300                 


Leu Asp Trp Glu Gly Glu Asp Ile Leu Asp Arg Ser Ser Glu Leu Ile 
305                 310                 315                 320 


Tyr Xaa Gly Glu Met Ala Trp Ile Tyr Gln Pro Tyr Gly Arg Asn Gln 
                325                 330                 335     


Gln Arg Val Phe Phe Leu Phe Asp His Gln Met Val Leu Cys Lys Lys 
            340                 345                 350         


Asp Leu Ile Arg Arg Asp Ile Leu Tyr Tyr Lys Gly Arg Ile Asp Met 
        355                 360                 365             


Asp Lys Tyr Glu Val Val Asp Ile Glu Asp Gly Arg Asp Asp Asp Phe 
    370                 375                 380                 


Asn Val Ser Met Lys Asn Ala Phe Lys Leu His Asn Lys Glu Xaa Glu 
385                 390                 395                 400 


Glu Ile His Leu Phe Phe Ala Lys Lys Leu Glu Glu Lys Ile Arg Trp 
                405                 410                 415     


Leu Arg Ala Phe Arg Glu Glu Arg Lys Met Val Gln Glu Asp Glu Lys 
            420                 425                 430         


Ile Gly Phe Glu Ile Ser Glu Asn Gln Lys Arg Gln Ala Ala Met Xaa 
        435                 440                 445             


Val Arg Lys Val Pro Lys Gln Lys Gly Ser 
    450                 455             


<210> 3086
<211> 516
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<400> 3086
Met Xaa Leu Leu Ile Xaa Gly Asp Ser Ile Val Ser Ala Glu Ala Val 
1               5                   10                  15      


Trp Asp His Val Xaa Met Ala Asn Arg Glu Leu Ala Phe Lys Ala Gly 
            20                  25                  30          


Asp Val Ile Lys Val Leu Asp Ala Ser Asn Lys Asp Trp Trp Trp Gly 
        35                  40                  45              


Gln Ile Asp Asp Glu Glu Gly Trp Phe Pro Ala Ser Phe Val Arg Leu 
    50                  55                  60                  


Trp Val Asn Gln Glu Asp Glu Val Glu Glu Gly Pro Ser Asp Val Gln 
65                  70                  75                  80  


Asn Gly His Leu Asp Pro Asn Ser Asp Cys Leu Cys Leu Gly Arg Pro 
                85                  90                  95      


Leu Gln Asn Arg Asp Gln Met Arg Ala Asn Val Ile Asn Glu Ile Met 
            100                 105                 110         


Ser Xaa Glu Arg His Tyr Ile Lys His Leu Lys Asp Ile Cys Glu Gly 
        115                 120                 125             


Tyr Leu Lys Gln Cys Arg Lys Arg Arg Asp Met Phe Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Val Ile Phe Gly Asn Ile Glu Asp Ile Tyr Arg Phe Gln Met 
145                 150                 155                 160 


Gly Phe Val Arg Asp Leu Glu Lys Gln Tyr Asn Asn Asp Asp Pro His 
                165                 170                 175     


Leu Ser Glu Ile Gly Pro Cys Phe Leu Glu His Gln Asp Gly Phe Trp 
            180                 185                 190         


Ile Tyr Ser Glu Tyr Cys Asn Asn His Leu Asp Ala Cys Met Glu Leu 
        195                 200                 205             


Ser Lys Leu Met Lys Asp Ser Arg Tyr Gln His Phe Phe Glu Ala Cys 
    210                 215                 220                 


Arg Leu Leu Gln Gln Met Ile Asp Ile Ala Ile Asp Gly Phe Leu Leu 
225                 230                 235                 240 


Xaa Pro Val Gln Lys Ile Cys Lys Tyr Pro Leu Gln Leu Ala Glu Leu 
                245                 250                 255     


Leu Lys Tyr Xaa Ala Gln Asp His Ser Asp Tyr Arg Tyr Val Ala Ala 
            260                 265                 270         


Ala Leu Ala Val Met Arg Asn Val Xaa Gln Gln Ile Asn Glu Arg Lys 
        275                 280                 285             


Arg Arg Leu Glu Asn Ile Asp Lys Ile Ala Gln Trp Gln Ala Ser Val 
    290                 295                 300                 


Leu Asp Trp Glu Gly Glu Asp Ile Leu Asp Arg Ser Ser Glu Leu Ile 
305                 310                 315                 320 


Tyr Xaa Gly Glu Met Ala Trp Ile Tyr Gln Pro Tyr Gly Arg Asn Gln 
                325                 330                 335     


Gln Arg Val Phe Phe Leu Phe Asp His Gln Met Val Leu Cys Lys Lys 
            340                 345                 350         


Asp Leu Ile Arg Arg Asp Ile Leu Tyr Tyr Lys Gly Arg Ile Asp Met 
        355                 360                 365             


Asp Lys Tyr Glu Val Val Asp Ile Glu Asp Gly Arg Asp Asp Asp Phe 
    370                 375                 380                 


Asn Val Ser Met Lys Asn Ala Phe Lys Leu His Asn Lys Glu Xaa Glu 
385                 390                 395                 400 


Glu Ile His Leu Phe Phe Ala Lys Lys Leu Glu Glu Lys Ile Arg Trp 
                405                 410                 415     


Leu Arg Ala Phe Arg Glu Glu Arg Lys Met Val Gln Glu Asp Glu Lys 
            420                 425                 430         


Ile Gly Phe Glu Ile Ser Glu Asn Gln Lys Arg Gln Ala Ala Met Xaa 
        435                 440                 445             


Val Arg Lys Val Pro Lys Gln Lys Gly Val Asn Ser Ala Arg Ser Val 
    450                 455                 460                 


Pro Pro Ser Tyr Pro Pro Pro Gln Asp Pro Leu Asn His Gly Gln Tyr 
465                 470                 475                 480 


Leu Val Pro Asp Gly Ile Ala Gln Ser Gln Val Phe Glu Phe Xaa Glu 
                485                 490                 495     


Pro Lys Arg Ser Gln Ser Pro Phe Trp Gln Asn Phe Ser Arg Leu Xaa 
            500                 505                 510         


Pro Phe Lys Lys 
        515     


<210> 3087
<211> 564
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<400> 3087
Met Xaa Leu Leu Ile Xaa Gly Asp Ser Ile Val Ser Ala Glu Ala Val 
1               5                   10                  15      


Trp Asp His Val Xaa Met Ala Asn Arg Glu Leu Ala Phe Lys Ala Gly 
            20                  25                  30          


Asp Val Ile Lys Val Leu Asp Ala Ser Asn Lys Asp Trp Trp Trp Gly 
        35                  40                  45              


Gln Ile Asp Asp Glu Glu Gly Trp Phe Pro Ala Ser Phe Val Arg Leu 
    50                  55                  60                  


Trp Val Asn Gln Glu Asp Glu Val Glu Glu Gly Pro Ser Asp Val Gln 
65                  70                  75                  80  


Asn Gly His Leu Asp Pro Asn Ser Asp Cys Leu Cys Leu Gly Arg Pro 
                85                  90                  95      


Leu Gln Asn Arg Asp Gln Met Arg Ala Asn Val Ile Asn Glu Ile Met 
            100                 105                 110         


Ser Xaa Glu Arg His Tyr Ile Lys His Leu Lys Asp Ile Cys Glu Gly 
        115                 120                 125             


Tyr Leu Lys Gln Cys Arg Lys Arg Arg Asp Met Phe Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Val Ile Phe Gly Asn Ile Glu Asp Ile Tyr Arg Phe Gln Met 
145                 150                 155                 160 


Gly Phe Val Arg Asp Leu Glu Lys Gln Tyr Asn Asn Asp Asp Pro His 
                165                 170                 175     


Leu Ser Glu Ile Gly Pro Cys Phe Leu Glu His Gln Asp Gly Phe Trp 
            180                 185                 190         


Ile Tyr Ser Glu Tyr Cys Asn Asn His Leu Asp Ala Cys Met Glu Leu 
        195                 200                 205             


Ser Lys Leu Met Lys Asp Ser Arg Tyr Gln His Phe Phe Glu Ala Cys 
    210                 215                 220                 


Arg Leu Leu Gln Gln Met Ile Asp Ile Ala Ile Asp Gly Phe Leu Leu 
225                 230                 235                 240 


Xaa Pro Val Gln Lys Ile Cys Lys Tyr Pro Leu Gln Leu Ala Glu Leu 
                245                 250                 255     


Leu Lys Tyr Xaa Ala Gln Asp His Ser Asp Tyr Arg Tyr Val Ala Ala 
            260                 265                 270         


Ala Leu Ala Val Met Arg Asn Val Xaa Gln Gln Ile Asn Glu Arg Lys 
        275                 280                 285             


Arg Arg Leu Glu Asn Ile Asp Lys Ile Ala Gln Trp Gln Ala Ser Val 
    290                 295                 300                 


Leu Asp Trp Glu Gly Glu Asp Ile Leu Asp Arg Ser Ser Glu Leu Ile 
305                 310                 315                 320 


Tyr Xaa Gly Glu Met Ala Trp Ile Tyr Gln Pro Tyr Gly Arg Asn Gln 
                325                 330                 335     


Gln Arg Val Phe Phe Leu Phe Asp His Gln Met Val Leu Cys Lys Lys 
            340                 345                 350         


Asp Leu Ile Arg Arg Asp Ile Leu Tyr Tyr Lys Gly Arg Ile Asp Met 
        355                 360                 365             


Asp Lys Tyr Glu Val Val Asp Ile Glu Asp Gly Arg Asp Asp Asp Phe 
    370                 375                 380                 


Asn Val Ser Met Lys Asn Ala Phe Lys Leu His Asn Lys Glu Xaa Glu 
385                 390                 395                 400 


Glu Ile His Leu Phe Phe Ala Lys Lys Leu Glu Glu Lys Ile Arg Trp 
                405                 410                 415     


Leu Arg Ala Phe Arg Glu Glu Arg Lys Met Val Gln Glu Asp Glu Lys 
            420                 425                 430         


Ile Gly Phe Glu Ile Ser Glu Asn Gln Lys Arg Gln Ala Ala Met Xaa 
        435                 440                 445             


Val Arg Lys Val Pro Lys Gln Lys Gly Val Asn Ser Ala Arg Ser Val 
    450                 455                 460                 


Pro Pro Ser Tyr Pro Pro Pro Gln Asp Pro Leu Asn His Gly Gln Tyr 
465                 470                 475                 480 


Leu Val Pro Asp Gly Ile Ala Gln Ser Gln Val Phe Glu Phe Xaa Glu 
                485                 490                 495     


Pro Lys Arg Ser Gln Ser Pro Phe Trp Gln Asn Phe Ser Arg Tyr Cys 
            500                 505                 510         


Glu Gly Ile Lys Lys Pro Asn Arg Ser Lys Gly Val Ser Asp Tyr Asp 
        515                 520                 525             


Asp Ala Gly Val Asp Phe Cys Ser Gly Asn Ile Leu His Ser Gly Cys 
    530                 535                 540                 


Phe Phe Tyr His Trp Gly Phe Pro Cys Cys Ser Xaa Ser Gly Ser Leu 
545                 550                 555                 560 


Gln Phe Cys Ile 
                


<210> 3088
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<400> 3088
Met Xaa Leu Leu Ile Xaa Gly Asp Ser Ile Val Ser Ala Glu Ala Val 
1               5                   10                  15      


Trp Asp His Val Xaa Met Ala Asn Arg Glu Leu Ala Phe Lys Ala Gly 
            20                  25                  30          


Asp Val Ile Lys Val Leu Asp Ala Ser Asn Lys Asp Trp Trp Trp Gly 
        35                  40                  45              


Gln Ile Asp Asp Glu Glu Gly Trp Phe Pro Ala Ser Phe Val Arg Leu 
    50                  55                  60                  


Trp Val Asn Gln Glu Asp Glu Val Glu Glu Gly Pro Ser Asp Val Gln 
65                  70                  75                  80  


Asn Gly His Leu Asp Pro Asn Ser Asp Cys Leu Cys Leu Gly Arg Pro 
                85                  90                  95      


Leu Gln Asn Arg Asp Gln Met Arg Ala Asn Val Ile Asn Glu Ile Met 
            100                 105                 110         


Ser Xaa Glu Arg His Tyr Ile Lys His Leu Lys Asp Ile Cys Glu Lys 
        115                 120                 125             


Val Gly Gly Asp Met Ile Leu Leu 
    130                 135     


<210> 3089
<211> 35
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<400> 3089
Xaa Phe Glu Ile Ser Glu Asn Gln Lys Arg Gln Ala Ala Met Xaa Val 
1               5                   10                  15      


Arg Lys Val Pro Lys Gln Lys Asp Ile Tyr Pro Glu Glu Ile Val Ile 
            20                  25                  30          


Ile Lys Val 
        35  


<210> 3090
<211> 263
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<400> 3090
Xaa Gly Arg Pro Leu Gln Asn Arg Asp Gln Met Arg Ala Asn Val Ile 
1               5                   10                  15      


Asn Glu Ile Met Ser Xaa Glu Arg His Tyr Ile Lys His Leu Lys Asp 
            20                  25                  30          


Ile Cys Glu Gly Tyr Leu Lys Gln Cys Arg Lys Arg Arg Asp Met Phe 
        35                  40                  45              


Ser Asp Glu Gln Leu Lys Val Ile Phe Gly Asn Ile Glu Asp Ile Tyr 
    50                  55                  60                  


Arg Phe Gln Met Gly Phe Val Arg Asp Leu Glu Lys Gln Tyr Asn Asn 
65                  70                  75                  80  


Asp Asp Pro His Leu Ser Glu Ile Gly Pro Cys Phe Leu Glu His Gln 
                85                  90                  95      


Asp Gly Phe Trp Ile Tyr Ser Glu Tyr Cys Asn Asn His Leu Asp Ala 
            100                 105                 110         


Cys Met Glu Leu Ser Lys Leu Met Lys Asp Ser Arg Tyr Gln His Phe 
        115                 120                 125             


Phe Glu Ala Cys Arg Leu Leu Gln Gln Met Ile Asp Ile Ala Ile Asp 
    130                 135                 140                 


Gly Phe Leu Leu Xaa Pro Val Gln Lys Ile Cys Lys Tyr Pro Leu Gln 
145                 150                 155                 160 


Leu Ala Glu Leu Leu Lys Tyr Xaa Ala Gln Asp His Ser Asp Tyr Arg 
                165                 170                 175     


Tyr Val Ala Ala Ala Leu Ala Val Met Arg Asn Val Xaa Gln Gln Ile 
            180                 185                 190         


Asn Glu Arg Lys Arg Arg Leu Glu Asn Ile Asp Lys Ile Ala Gln Trp 
        195                 200                 205             


Gln Ala Ser Val Leu Asp Trp Glu Gly Glu Asp Ile Leu Asp Arg Ser 
    210                 215                 220                 


Ser Glu Leu Ile Tyr Xaa Gly Glu Met Ala Trp Ile Tyr Gln Pro Tyr 
225                 230                 235                 240 


Gly Arg Asn Gln Gln Arg Val Phe Phe Leu Phe Asp His Gln Met Val 
                245                 250                 255     


Leu Cys Lys Lys Gln Met Cys 
            260             


<210> 3091
<211> 91
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<400> 3091
Xaa Val Met Arg Asn Val Xaa Gln Gln Ile Asn Glu Arg Lys Arg Arg 
1               5                   10                  15      


Leu Glu Asn Ile Asp Lys Ile Ala Gln Trp Gln Ala Ser Val Leu Asp 
            20                  25                  30          


Trp Glu Gly Glu Asp Ile Leu Asp Arg Ser Ser Glu Leu Ile Tyr Xaa 
        35                  40                  45              


Gly Glu Met Ala Trp Ile Tyr Gln Pro Tyr Gly Arg Asn Gln Gln Arg 
    50                  55                  60                  


Val Phe Phe Leu Phe Asp His Gln Met Val Leu Cys Lys Lys Ala Leu 
65                  70                  75                  80  


Lys Phe Leu Lys Xaa Arg Arg Gly Arg Leu Gln 
                85                  90      


<210> 3092
<211> 2068
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1206)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1359)..(1360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1382)..(1382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1432)..(1432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1443)..(1443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1449)..(1449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1486)..(1486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1526)..(1526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1634)..(1635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1666)..(1667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1671)..(1671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1674)..(1675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1691)..(1691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1693)..(1693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1700)..(1700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1704)..(1704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1706)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1748)..(1748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1752)..(1752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1770)..(1770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1813)..(1813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1843)..(1843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1846)..(1846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1888)..(1888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1904)..(1904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1921)..(1921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1933)..(1933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1989)..(1989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2009)..(2009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2035)..(2035)
<223> Selenocysteine

<400> 3092
Met Ala Ala Gln Val Ala Pro Ala Ala Ala Ser Ser Leu Gly Asn Pro 
1               5                   10                  15      


Pro Pro Pro Pro Pro Ser Glu Leu Lys Lys Ala Glu Gln Gln Gln Arg 
            20                  25                  30          


Glu Glu Ala Gly Gly Glu Ala Ala Ala Ala Ala Ala Ala Glu Arg Gly 
        35                  40                  45              


Glu Met Lys Ala Ala Ala Gly Gln Glu Ser Glu Gly Pro Ala Val Gly 
    50                  55                  60                  


Pro Pro Gln Pro Leu Gly Lys Glu Leu Gln Asp Gly Ala Glu Ser Asn 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Ala Gly Ser Gly Gly Gly Pro Gly Ala 
                85                  90                  95      


Glu Pro Asp Leu Lys Asn Ser Asn Gly Asn Ala Gly Pro Arg Pro Ala 
            100                 105                 110         


Leu Asn Asn Asn Leu Xaa Glu Pro Pro Gly Gly Gly Gly Gly Gly Ser 
        115                 120                 125             


Ser Asp Gly Val Gly Ala Pro Pro His Ser Ala Ala Ala Ala Leu Pro 
    130                 135                 140                 


Pro Pro Ala Tyr Gly Phe Gly Gln Pro Tyr Gly Arg Ser Pro Ser Ala 
145                 150                 155                 160 


Val Ala Ala Ala Ala Ala Ala Val Phe His Gln Gln His Gly Gly Gln 
                165                 170                 175     


Gln Ser Pro Gly Leu Ala Ala Leu Gln Ser Gly Gly Gly Gly Gly Leu 
            180                 185                 190         


Glu Pro Tyr Ala Gly Pro Gln Gln Asn Ser His Asp His Gly Phe Pro 
        195                 200                 205             


Asn His Gln Tyr Asn Ser Tyr Tyr Pro Asn Arg Ser Ala Tyr Pro Pro 
    210                 215                 220                 


Pro Ala Pro Ala Tyr Ala Leu Ser Ser Pro Arg Gly Gly Xaa Pro Gly 
225                 230                 235                 240 


Ser Gly Ala Ala Ala Ala Ala Gly Ser Lys Pro Pro Pro Ser Ser Ser 
                245                 250                 255     


Ala Ser Ala Ser Ser Ser Ser Ser Ser Phe Ala Gln Gln Arg Phe Gly 
            260                 265                 270         


Ala Met Gly Gly Gly Gly Pro Ser Ala Ala Gly Gly Gly Xaa Pro Gln 
        275                 280                 285             


Pro Xaa Ala Xaa Pro Xaa Leu Asn Gln Leu Leu Xaa Ser Pro Ser Ser 
    290                 295                 300                 


Ala Arg Gly Tyr Gln Gly Tyr Pro Gly Gly Asp Tyr Ser Gly Gly Pro 
305                 310                 315                 320 


Gln Asp Gly Gly Ala Gly Lys Gly Pro Ala Asp Met Ala Ser Gln Cys 
                325                 330                 335     


Trp Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Gly 
            340                 345                 350         


Ala Gln Gln Arg Ser His His Ala Pro Met Ser Pro Gly Ser Ser Gly 
        355                 360                 365             


Gly Gly Gly Gln Pro Leu Ala Arg Xaa Pro Gln Pro Ser Ser Pro Met 
    370                 375                 380                 


Asp Gln Met Gly Lys Met Arg Pro Gln Pro Tyr Gly Gly Xaa Asn Pro 
385                 390                 395                 400 


Tyr Ser Gln Gln Gln Gly Pro Pro Ser Gly Pro Gln Gln Gly His Gly 
                405                 410                 415     


Tyr Pro Gly Gln Pro Tyr Gly Ser Gln Xaa Pro Gln Arg Tyr Pro Met 
            420                 425                 430         


Xaa Met Gln Gly Arg Ala Gln Ser Ala Met Gly Gly Leu Ser Tyr Xaa 
        435                 440                 445             


Gln Gln Ile Pro Pro Tyr Gly Gln Gln Gly Pro Ser Gly Tyr Gly Gln 
    450                 455                 460                 


Gln Gly Gln Xaa Pro Tyr Tyr Asn Gln Gln Ser Pro His Pro Gln Gln 
465                 470                 475                 480 


Gln Gln Pro Pro Tyr Ser Gln Gln Pro Pro Ser Gln Xaa Pro His Ala 
                485                 490                 495     


Gln Pro Ser Tyr Gln Gln Gln Pro Gln Ser Gln Pro Pro Gln Leu Gln 
            500                 505                 510         


Ser Ser Gln Pro Pro Tyr Ser Gln Gln Pro Ser Gln Pro Pro His Gln 
        515                 520                 525             


Gln Ser Pro Ala Pro Tyr Pro Ser Gln Gln Ser Xaa Xaa Gln Gln His 
    530                 535                 540                 


Pro Gln Ser Gln Pro Pro Tyr Ser Gln Pro Gln Ala Gln Ser Pro Tyr 
545                 550                 555                 560 


Gln Gln Gln Gln Pro Gln Gln Pro Ala Pro Ser Xaa Leu Ser Gln Gln 
                565                 570                 575     


Ala Ala Tyr Pro Gln Pro Gln Ser Gln Gln Ser Gln Gln Xaa Ala Tyr 
            580                 585                 590         


Ser Gln Gln Arg Phe Pro Pro Pro Gln Glu Leu Ser Gln Asp Ser Phe 
        595                 600                 605             


Gly Ser Gln Ala Ser Ser Ala Pro Ser Met Xaa Ser Ser Lys Gly Gly 
    610                 615                 620                 


Gln Glu Asp Met Asn Leu Ser Leu Gln Ser Arg Pro Ser Ser Leu Pro 
625                 630                 635                 640 


Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Met Gly Xaa Glu Gly Ala 
                645                 650                 655     


Leu Ser Pro Gly Val Ser Xaa Ser Gly Ile Ser Ser Ser Gln Gly Glu 
            660                 665                 670         


Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Xaa Ser Pro His 
        675                 680                 685             


Leu Pro Gly Ile Arg Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Ala 
    690                 695                 700                 


Ser Val Ala Gln Ser Arg Ser Gly Pro Leu Ser Pro Ala Ala Val Pro 
705                 710                 715                 720 


Gly Asn Gln Met Pro Pro Arg Pro Pro Ser Gly Gln Ser Asp Ser Ile 
                725                 730                 735     


Met His Pro Ser Met Asn Gln Ser Ser Ile Ala Gln Asp Arg Gly Tyr 
            740                 745                 750         


Met Gln Arg Asn Pro Gln Met Pro Gln Tyr Ser Ser Pro Gln Pro Gly 
        755                 760                 765             


Ser Ala Leu Ser Pro Arg Gln Pro Ser Gly Gly Gln Ile His Xaa Gly 
    770                 775                 780                 


Met Gly Ser Tyr Gln Gln Asn Ser Met Gly Ser Tyr Gly Pro Gln Gly 
785                 790                 795                 800 


Gly Gln Tyr Gly Pro Gln Gly Gly Tyr Pro Arg Gln Pro Asn Tyr Asn 
                805                 810                 815     


Ala Leu Pro Asn Ala Asn Tyr Pro Ser Ala Gly Met Ala Gly Gly Ile 
            820                 825                 830         


Asn Pro Met Gly Ala Gly Gly Gln Met His Gly Gln Pro Gly Ile Pro 
        835                 840                 845             


Pro Tyr Gly Xaa Leu Pro Pro Gly Arg Met Ser His Ala Ser Met Gly 
    850                 855                 860                 


Asn Arg Pro Tyr Gly Pro Asn Met Ala Asn Met Pro Pro Gln Val Gly 
865                 870                 875                 880 


Ser Gly Met Cys Pro Pro Pro Gly Gly Met Asn Arg Lys Xaa Gln Glu 
                885                 890                 895     


Xaa Ala Val Ala Met His Val Ala Ala Asn Ser Ile Gln Asn Arg Pro 
            900                 905                 910         


Pro Gly Tyr Pro Asn Met Asn Gln Gly Gly Met Met Gly Xaa Gly Pro 
        915                 920                 925             


Pro Tyr Gly Gln Gly Ile Asn Ser Met Ala Gly Met Ile Asn Pro Gln 
    930                 935                 940                 


Gly Pro Pro Tyr Ser Met Gly Gly Xaa Met Ala Asn Asn Ser Ala Gly 
945                 950                 955                 960 


Met Ala Ala Ser Pro Glu Met Met Gly Leu Gly Asp Val Lys Leu Xaa 
                965                 970                 975     


Pro Ala Xaa Lys Met Asn Asn Lys Ala Asp Gly Xaa Pro Lys Xaa Glu 
            980                 985                 990         


Ser Lys Ser Lys Lys Ser Ser Ser  Ser Xaa Xaa Xaa Asn  Glu Lys Ile 
        995                 1000                 1005             


Xaa Lys  Leu Tyr Glu Leu Gly  Gly Glu Pro Glu Arg  Lys Met Trp 
    1010                 1015                 1020             


Val Asp  Arg Tyr Leu Ala Phe  Xaa Glu Glu Lys Ala  Met Gly Met 
    1025                 1030                 1035             


Xaa Asn  Leu Pro Ala Val Gly  Arg Lys Pro Leu Asp  Leu Tyr Arg 
    1040                 1045                 1050             


Leu Tyr  Val Ser Val Lys Glu  Ile Gly Gly Leu Xaa  Gln Val Asn 
    1055                 1060                 1065             


Lys Asn  Lys Lys Trp Arg Glu  Leu Ala Xaa Asn Leu  Asn Val Gly 
    1070                 1075                 1080             


Xaa Ser  Ser Ser Ala Ala Ser  Ser Leu Lys Lys Gln  Tyr Ile Gln 
    1085                 1090                 1095             


Cys Leu  Tyr Ala Phe Glu Cys  Lys Ile Glu Arg Gly  Glu Asp Pro 
    1100                 1105                 1110             


Pro Pro  Asp Ile Phe Ala Ala  Ala Asp Ser Lys Lys  Ser Gln Pro 
    1115                 1120                 1125             


Lys Ile  Gln Pro Pro Ser Pro  Ala Gly Ser Gly Ser  Met Gln Gly 
    1130                 1135                 1140             


Pro Gln  Xaa Pro Gln Ser Xaa  Ser Ser Ser Met Ala  Glu Gly Gly 
    1145                 1150                 1155             


Asp Leu  Lys Pro Pro Xaa Pro  Ala Ser Xaa Pro His  Ser Gln Ile 
    1160                 1165                 1170             


Pro Pro  Leu Pro Gly Met Ser  Arg Ser Asn Ser Val  Gly Ile Gln 
    1175                 1180                 1185             


Asp Ala  Phe Asn Asp Gly Ser  Asp Ser Xaa Phe Gln  Lys Arg Asn 
    1190                 1195                 1200             


Ser Met  Xaa Pro Asn Pro Gly  Tyr Gln Pro Ser Met  Asn Xaa Ser 
    1205                 1210                 1215             


Asp Met  Met Gly Arg Met Ser  Tyr Glu Pro Asn Lys  Asp Pro Tyr 
    1220                 1225                 1230             


Gly Ser  Met Arg Lys Ala Pro  Gly Ser Asp Pro Phe  Met Ser Ser 
    1235                 1240                 1245             


Gly Gln  Gly Pro Asn Gly Gly  Met Gly Asp Pro Tyr  Ser Arg Ala 
    1250                 1255                 1260             


Ala Gly  Pro Gly Leu Gly Asn  Val Ala Met Gly Pro  Arg Gln His 
    1265                 1270                 1275             


Tyr Pro  Tyr Gly Gly Pro Tyr  Asp Arg Val Arg Xaa  Glu Pro Gly 
    1280                 1285                 1290             


Ile Gly  Pro Glu Gly Asn Met  Ser Xaa Gly Ala Pro  Gln Pro Asn 
    1295                 1300                 1305             


Leu Met  Pro Ser Asn Pro Asp  Ser Gly Met Tyr Ser  Pro Ser Arg 
    1310                 1315                 1320             


Tyr Pro  Pro Gln Gln Gln Gln  Gln Gln Gln Gln Arg  His Asp Ser 
    1325                 1330                 1335             


Tyr Gly  Asn Gln Phe Ser Xaa  Gln Gly Xaa Pro Ser  Gly Ser Pro 
    1340                 1345                 1350             


Phe Pro  Ser Gln Gln Xaa Xaa  Met Tyr Gln Gln Gln  Gln Gln Val 
    1355                 1360                 1365             


Ser Ser  Pro Ala Pro Leu Pro  Arg Pro Met Glu Asn  Arg Xaa Ser 
    1370                 1375                 1380             


Pro Ser  Lys Ser Pro Phe Leu  His Ser Gly Met Lys  Met Gln Lys 
    1385                 1390                 1395             


Ala Gly  Pro Pro Val Pro Ala  Ser His Ile Ala Pro  Ala Pro Val 
    1400                 1405                 1410             


Gln Pro  Pro Met Ile Arg Arg  Asp Ile Xaa Phe Pro  Pro Gly Ser 
    1415                 1420                 1425             


Val Glu  Ala Xaa Gln Pro Val  Leu Lys Gln Arg Arg  Arg Leu Xaa 
    1430                 1435                 1440             


Met Lys  Asp Ile Gly Xaa Pro  Glu Ala Trp Arg Val  Met Met Ser 
    1445                 1450                 1455             


Leu Lys  Ser Gly Leu Leu Ala  Glu Ser Xaa Trp Ala  Leu Asp Xaa 
    1460                 1465                 1470             


Ile Asn  Ile Leu Leu Tyr Asp  Asp Asn Ser Ile Met  Xaa Phe Asn 
    1475                 1480                 1485             


Leu Ser  Gln Leu Pro Gly Leu  Leu Glu Leu Leu Val  Glu Tyr Phe 
    1490                 1495                 1500             


Arg Arg  Cys Leu Ile Glu Ile  Phe Gly Ile Leu Lys  Glu Tyr Glu 
    1505                 1510                 1515             


Val Gly  Asp Pro Gly Gln Arg  Xaa Leu Leu Asp Pro  Gly Arg Phe 
    1520                 1525                 1530             


Ser Lys  Val Ser Ser Pro Ala  Pro Met Glu Gly Gly  Glu Glu Glu 
    1535                 1540                 1545             


Glu Glu  Leu Leu Gly Pro Lys  Leu Glu Glu Glu Glu  Glu Glu Glu 
    1550                 1555                 1560             


Val Val  Glu Asn Asp Glu Glu  Ile Ala Phe Ser Gly  Lys Asp Lys 
    1565                 1570                 1575             


Pro Ala  Ser Glu Asn Ser Glu  Glu Lys Leu Ile Ser  Lys Phe Asp 
    1580                 1585                 1590             


Lys Leu  Pro Val Lys Ile Val  Gln Lys Asn Asp Pro  Phe Val Val 
    1595                 1600                 1605             


Asp Cys  Ser Asp Lys Leu Gly  Arg Val Gln Glu Phe  Asp Ser Gly 
    1610                 1615                 1620             


Leu Leu  His Trp Arg Ile Gly  Gly Gly Asp Xaa Xaa  Glu His Ile 
    1625                 1630                 1635             


Gln Xaa  His Phe Glu Ser Lys  Xaa Glu Leu Leu Pro  Ser Arg Pro 
    1640                 1645                 1650             


His Ala  Pro Cys Pro Pro Ala  Pro Arg Lys His Val  Xaa Xaa Ala 
    1655                 1660                 1665             


Glu Gly  Xaa Pro Gly Xaa Xaa  Asp Gln Glu Gly Pro  Pro Pro Asp 
    1670                 1675                 1680             


Gly Pro  Pro Glu Lys Arg Ile  Xaa Ala Xaa Met Asp  Asp Met Leu 
    1685                 1690                 1695             


Ser Xaa  Arg Ser Ser Xaa Leu  Xaa Glu Asp Gly Ala  Lys Ser Ser 
    1700                 1705                 1710             


Glu Ala  Ile Lys Glu Ser Ser  Lys Phe Pro Phe Gly  Ile Ser Pro 
    1715                 1720                 1725             


Ala Gln  Ser His Arg Asn Ile  Lys Ile Leu Glu Asp  Glu Pro His 
    1730                 1735                 1740             


Ser Lys  Asp Glu Xaa Pro Leu  Cys Xaa Leu Leu Asp  Trp Gln Asp 
    1745                 1750                 1755             


Ser Leu  Ala Lys Arg Cys Val  Cys Val Ser Asn Xaa  Ile Arg Ser 
    1760                 1765                 1770             


Leu Ser  Phe Val Pro Gly Asn  Asp Phe Glu Met Ser  Lys His Pro 
    1775                 1780                 1785             


Gly Leu  Leu Leu Ile Leu Gly  Lys Leu Ile Leu Leu  His His Lys 
    1790                 1795                 1800             


His Pro  Glu Arg Lys Gln Ala  Pro Leu Xaa Tyr Glu  Lys Glu Glu 
    1805                 1810                 1815             


Glu Gln  Asp Gln Gly Val Ser  Cys Asn Lys Val Glu  Trp Trp Trp 
    1820                 1825                 1830             


Asp Cys  Leu Glu Met Leu Arg  Glu Asn Xaa Leu Val  Xaa Leu Ala 
    1835                 1840                 1845             


Asn Ile  Ser Gly Gln Leu Asp  Leu Ser Pro Tyr Pro  Glu Ser Ile 
    1850                 1855                 1860             


Cys Leu  Pro Val Leu Asp Gly  Leu Leu His Trp Ala  Val Cys Pro 
    1865                 1870                 1875             


Ser Ala  Glu Ala Gln Asp Pro  Phe Ser Xaa Leu Gly  Pro Asn Ala 
    1880                 1885                 1890             


Val Leu  Ser Pro Gln Arg Leu  Val Leu Glu Xaa Leu  Ser Lys Leu 
    1895                 1900                 1905             


Ser Ile  Gln Asp Asn Asn Val  Asp Leu Ile Leu Ala  Xaa Pro Pro 
    1910                 1915                 1920             


Phe Ser  Arg Leu Glu Lys Leu  Tyr Ser Xaa Met Val  Arg Phe Leu 
    1925                 1930                 1935             


Ser Asp  Arg Lys Asn Pro Val  Cys Arg Glu Met Ala  Val Val Leu 
    1940                 1945                 1950             


Leu Ala  Asn Leu Ala Gln Gly  Asp Ser Leu Ala Ala  Arg Ala Ile 
    1955                 1960                 1965             


Ala Val  Gln Lys Gly Ser Ile  Gly Asn Leu Leu Gly  Phe Leu Glu 
    1970                 1975                 1980             


Asp Ser  Leu Ala Ala Xaa Gln  Phe Gln Gln Ser Gln  Ala Ser Leu 
    1985                 1990                 1995             


Leu His  Met Gln Asn Pro Pro  Phe Glu Pro Xaa Ser  Val Asp Met 
    2000                 2005                 2010             


Met Arg  Arg Ala Ala Arg Ala  Leu Leu Ala Leu Ala  Lys Val Asp 
    2015                 2020                 2025             


Glu Asn  His Ser Glu Phe Xaa  Leu Tyr Glu Ser Arg  Leu Leu Asp 
    2030                 2035                 2040             


Ile Ser  Val Ser Pro Leu Met  Asn Ser Leu Val Ser  Gln Val Ile 
    2045                 2050                 2055             


Cys Asp  Val Leu Phe Leu Ile  Gly Gln Ser 
    2060                 2065             


<210> 3093
<211> 2285
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1206)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1359)..(1360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1395)..(1395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1438)..(1438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1440)..(1440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1443)..(1443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1470)..(1470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1496)..(1496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1505)..(1505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1514)..(1514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1529)..(1529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1535)..(1535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1550)..(1550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1565)..(1565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1599)..(1599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1649)..(1649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1660)..(1660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1666)..(1666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1685)..(1685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1690)..(1690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1703)..(1703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1743)..(1743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1851)..(1852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1857)..(1857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1863)..(1863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1883)..(1884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1888)..(1888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1891)..(1892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1908)..(1908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1910)..(1910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1917)..(1917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1921)..(1921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1923)..(1923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1965)..(1965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1969)..(1969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1987)..(1987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2030)..(2030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2060)..(2060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2063)..(2063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2105)..(2105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2121)..(2121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2138)..(2138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2150)..(2150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2206)..(2206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2226)..(2226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2252)..(2252)
<223> Selenocysteine

<400> 3093
Met Ala Ala Gln Val Ala Pro Ala Ala Ala Ser Ser Leu Gly Asn Pro 
1               5                   10                  15      


Pro Pro Pro Pro Pro Ser Glu Leu Lys Lys Ala Glu Gln Gln Gln Arg 
            20                  25                  30          


Glu Glu Ala Gly Gly Glu Ala Ala Ala Ala Ala Ala Ala Glu Arg Gly 
        35                  40                  45              


Glu Met Lys Ala Ala Ala Gly Gln Glu Ser Glu Gly Pro Ala Val Gly 
    50                  55                  60                  


Pro Pro Gln Pro Leu Gly Lys Glu Leu Gln Asp Gly Ala Glu Ser Asn 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Ala Gly Ser Gly Gly Gly Pro Gly Ala 
                85                  90                  95      


Glu Pro Asp Leu Lys Asn Ser Asn Gly Asn Ala Gly Pro Arg Pro Ala 
            100                 105                 110         


Leu Asn Asn Asn Leu Xaa Glu Pro Pro Gly Gly Gly Gly Gly Gly Ser 
        115                 120                 125             


Ser Asp Gly Val Gly Ala Pro Pro His Ser Ala Ala Ala Ala Leu Pro 
    130                 135                 140                 


Pro Pro Ala Tyr Gly Phe Gly Gln Pro Tyr Gly Arg Ser Pro Ser Ala 
145                 150                 155                 160 


Val Ala Ala Ala Ala Ala Ala Val Phe His Gln Gln His Gly Gly Gln 
                165                 170                 175     


Gln Ser Pro Gly Leu Ala Ala Leu Gln Ser Gly Gly Gly Gly Gly Leu 
            180                 185                 190         


Glu Pro Tyr Ala Gly Pro Gln Gln Asn Ser His Asp His Gly Phe Pro 
        195                 200                 205             


Asn His Gln Tyr Asn Ser Tyr Tyr Pro Asn Arg Ser Ala Tyr Pro Pro 
    210                 215                 220                 


Pro Ala Pro Ala Tyr Ala Leu Ser Ser Pro Arg Gly Gly Xaa Pro Gly 
225                 230                 235                 240 


Ser Gly Ala Ala Ala Ala Ala Gly Ser Lys Pro Pro Pro Ser Ser Ser 
                245                 250                 255     


Ala Ser Ala Ser Ser Ser Ser Ser Ser Phe Ala Gln Gln Arg Phe Gly 
            260                 265                 270         


Ala Met Gly Gly Gly Gly Pro Ser Ala Ala Gly Gly Gly Xaa Pro Gln 
        275                 280                 285             


Pro Xaa Ala Xaa Pro Xaa Leu Asn Gln Leu Leu Xaa Ser Pro Ser Ser 
    290                 295                 300                 


Ala Arg Gly Tyr Gln Gly Tyr Pro Gly Gly Asp Tyr Ser Gly Gly Pro 
305                 310                 315                 320 


Gln Asp Gly Gly Ala Gly Lys Gly Pro Ala Asp Met Ala Ser Gln Cys 
                325                 330                 335     


Trp Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Gly 
            340                 345                 350         


Ala Gln Gln Arg Ser His His Ala Pro Met Ser Pro Gly Ser Ser Gly 
        355                 360                 365             


Gly Gly Gly Gln Pro Leu Ala Arg Xaa Pro Gln Pro Ser Ser Pro Met 
    370                 375                 380                 


Asp Gln Met Gly Lys Met Arg Pro Gln Pro Tyr Gly Gly Xaa Asn Pro 
385                 390                 395                 400 


Tyr Ser Gln Gln Gln Gly Pro Pro Ser Gly Pro Gln Gln Gly His Gly 
                405                 410                 415     


Tyr Pro Gly Gln Pro Tyr Gly Ser Gln Xaa Pro Gln Arg Tyr Pro Met 
            420                 425                 430         


Xaa Met Gln Gly Arg Ala Gln Ser Ala Met Gly Gly Leu Ser Tyr Xaa 
        435                 440                 445             


Gln Gln Ile Pro Pro Tyr Gly Gln Gln Gly Pro Ser Gly Tyr Gly Gln 
    450                 455                 460                 


Gln Gly Gln Xaa Pro Tyr Tyr Asn Gln Gln Ser Pro His Pro Gln Gln 
465                 470                 475                 480 


Gln Gln Pro Pro Tyr Ser Gln Gln Pro Pro Ser Gln Xaa Pro His Ala 
                485                 490                 495     


Gln Pro Ser Tyr Gln Gln Gln Pro Gln Ser Gln Pro Pro Gln Leu Gln 
            500                 505                 510         


Ser Ser Gln Pro Pro Tyr Ser Gln Gln Pro Ser Gln Pro Pro His Gln 
        515                 520                 525             


Gln Ser Pro Ala Pro Tyr Pro Ser Gln Gln Ser Xaa Xaa Gln Gln His 
    530                 535                 540                 


Pro Gln Ser Gln Pro Pro Tyr Ser Gln Pro Gln Ala Gln Ser Pro Tyr 
545                 550                 555                 560 


Gln Gln Gln Gln Pro Gln Gln Pro Ala Pro Ser Xaa Leu Ser Gln Gln 
                565                 570                 575     


Ala Ala Tyr Pro Gln Pro Gln Ser Gln Gln Ser Gln Gln Xaa Ala Tyr 
            580                 585                 590         


Ser Gln Gln Arg Phe Pro Pro Pro Gln Glu Leu Ser Gln Asp Ser Phe 
        595                 600                 605             


Gly Ser Gln Ala Ser Ser Ala Pro Ser Met Xaa Ser Ser Lys Gly Gly 
    610                 615                 620                 


Gln Glu Asp Met Asn Leu Ser Leu Gln Ser Arg Pro Ser Ser Leu Pro 
625                 630                 635                 640 


Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Met Gly Xaa Glu Gly Ala 
                645                 650                 655     


Leu Ser Pro Gly Val Ser Xaa Ser Gly Ile Ser Ser Ser Gln Gly Glu 
            660                 665                 670         


Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Xaa Ser Pro His 
        675                 680                 685             


Leu Pro Gly Ile Arg Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Ala 
    690                 695                 700                 


Ser Val Ala Gln Ser Arg Ser Gly Pro Leu Ser Pro Ala Ala Val Pro 
705                 710                 715                 720 


Gly Asn Gln Met Pro Pro Arg Pro Pro Ser Gly Gln Ser Asp Ser Ile 
                725                 730                 735     


Met His Pro Ser Met Asn Gln Ser Ser Ile Ala Gln Asp Arg Gly Tyr 
            740                 745                 750         


Met Gln Arg Asn Pro Gln Met Pro Gln Tyr Ser Ser Pro Gln Pro Gly 
        755                 760                 765             


Ser Ala Leu Ser Pro Arg Gln Pro Ser Gly Gly Gln Ile His Xaa Gly 
    770                 775                 780                 


Met Gly Ser Tyr Gln Gln Asn Ser Met Gly Ser Tyr Gly Pro Gln Gly 
785                 790                 795                 800 


Gly Gln Tyr Gly Pro Gln Gly Gly Tyr Pro Arg Gln Pro Asn Tyr Asn 
                805                 810                 815     


Ala Leu Pro Asn Ala Asn Tyr Pro Ser Ala Gly Met Ala Gly Gly Ile 
            820                 825                 830         


Asn Pro Met Gly Ala Gly Gly Gln Met His Gly Gln Pro Gly Ile Pro 
        835                 840                 845             


Pro Tyr Gly Xaa Leu Pro Pro Gly Arg Met Ser His Ala Ser Met Gly 
    850                 855                 860                 


Asn Arg Pro Tyr Gly Pro Asn Met Ala Asn Met Pro Pro Gln Val Gly 
865                 870                 875                 880 


Ser Gly Met Cys Pro Pro Pro Gly Gly Met Asn Arg Lys Xaa Gln Glu 
                885                 890                 895     


Xaa Ala Val Ala Met His Val Ala Ala Asn Ser Ile Gln Asn Arg Pro 
            900                 905                 910         


Pro Gly Tyr Pro Asn Met Asn Gln Gly Gly Met Met Gly Xaa Gly Pro 
        915                 920                 925             


Pro Tyr Gly Gln Gly Ile Asn Ser Met Ala Gly Met Ile Asn Pro Gln 
    930                 935                 940                 


Gly Pro Pro Tyr Ser Met Gly Gly Xaa Met Ala Asn Asn Ser Ala Gly 
945                 950                 955                 960 


Met Ala Ala Ser Pro Glu Met Met Gly Leu Gly Asp Val Lys Leu Xaa 
                965                 970                 975     


Pro Ala Xaa Lys Met Asn Asn Lys Ala Asp Gly Xaa Pro Lys Xaa Glu 
            980                 985                 990         


Ser Lys Ser Lys Lys Ser Ser Ser  Ser Xaa Xaa Xaa Asn  Glu Lys Ile 
        995                 1000                 1005             


Xaa Lys  Leu Tyr Glu Leu Gly  Gly Glu Pro Glu Arg  Lys Met Trp 
    1010                 1015                 1020             


Val Asp  Arg Tyr Leu Ala Phe  Xaa Glu Glu Lys Ala  Met Gly Met 
    1025                 1030                 1035             


Xaa Asn  Leu Pro Ala Val Gly  Arg Lys Pro Leu Asp  Leu Tyr Arg 
    1040                 1045                 1050             


Leu Tyr  Val Ser Val Lys Glu  Ile Gly Gly Leu Xaa  Gln Val Asn 
    1055                 1060                 1065             


Lys Asn  Lys Lys Trp Arg Glu  Leu Ala Xaa Asn Leu  Asn Val Gly 
    1070                 1075                 1080             


Xaa Ser  Ser Ser Ala Ala Ser  Ser Leu Lys Lys Gln  Tyr Ile Gln 
    1085                 1090                 1095             


Cys Leu  Tyr Ala Phe Glu Cys  Lys Ile Glu Arg Gly  Glu Asp Pro 
    1100                 1105                 1110             


Pro Pro  Asp Ile Phe Ala Ala  Ala Asp Ser Lys Lys  Ser Gln Pro 
    1115                 1120                 1125             


Lys Ile  Gln Pro Pro Ser Pro  Ala Gly Ser Gly Ser  Met Gln Gly 
    1130                 1135                 1140             


Pro Gln  Xaa Pro Gln Ser Xaa  Ser Ser Ser Met Ala  Glu Gly Gly 
    1145                 1150                 1155             


Asp Leu  Lys Pro Pro Xaa Pro  Ala Ser Xaa Pro His  Ser Gln Ile 
    1160                 1165                 1170             


Pro Pro  Leu Pro Gly Met Ser  Arg Ser Asn Ser Val  Gly Ile Gln 
    1175                 1180                 1185             


Asp Ala  Phe Asn Asp Gly Ser  Asp Ser Xaa Phe Gln  Lys Arg Asn 
    1190                 1195                 1200             


Ser Met  Xaa Pro Asn Pro Gly  Tyr Gln Pro Ser Met  Asn Xaa Ser 
    1205                 1210                 1215             


Asp Met  Met Gly Arg Met Ser  Tyr Glu Pro Asn Lys  Asp Pro Tyr 
    1220                 1225                 1230             


Gly Ser  Met Arg Lys Ala Pro  Gly Ser Asp Pro Phe  Met Ser Ser 
    1235                 1240                 1245             


Gly Gln  Gly Pro Asn Gly Gly  Met Gly Asp Pro Tyr  Ser Arg Ala 
    1250                 1255                 1260             


Ala Gly  Pro Gly Leu Gly Asn  Val Ala Met Gly Pro  Arg Gln His 
    1265                 1270                 1275             


Tyr Pro  Tyr Gly Gly Pro Tyr  Asp Arg Val Arg Xaa  Glu Pro Gly 
    1280                 1285                 1290             


Ile Gly  Pro Glu Gly Asn Met  Ser Xaa Gly Ala Pro  Gln Pro Asn 
    1295                 1300                 1305             


Leu Met  Pro Ser Asn Pro Asp  Ser Gly Met Tyr Ser  Pro Ser Arg 
    1310                 1315                 1320             


Tyr Pro  Pro Gln Gln Gln Gln  Gln Gln Gln Gln Arg  His Asp Ser 
    1325                 1330                 1335             


Tyr Gly  Asn Gln Phe Ser Xaa  Gln Gly Xaa Pro Ser  Gly Ser Pro 
    1340                 1345                 1350             


Phe Pro  Ser Gln Gln Xaa Xaa  Met Tyr Gln Gln Gln  Gln Gln Asn 
    1355                 1360                 1365             


Tyr Lys  Arg Pro Met Asp Gly  Xaa Tyr Gly Pro Pro  Ala Lys Arg 
    1370                 1375                 1380             


His Glu  Gly Glu Met Tyr Ser  Val Pro Tyr Ser Xaa  Gly Gln Gly 
    1385                 1390                 1395             


Gln Pro  Gln Gln Gln Gln Leu  Pro Pro Ala Gln Pro  Gln Pro Ala 
    1400                 1405                 1410             


Ser Gln  Gln Gln Ala Ala Gln  Pro Ser Pro Gln Gln  Asp Val Tyr 
    1415                 1420                 1425             


Asn Gln  Tyr Gly Asn Ala Tyr  Pro Ala Xaa Ala Xaa  Ala Ala Xaa 
    1430                 1435                 1440             


Glu Arg  Arg Pro Ala Gly Gly  Pro Gln Asn Gln Phe  Pro Phe Gln 
    1445                 1450                 1455             


Phe Gly  Arg Asp Arg Val Ser  Ala Pro Pro Gly Xaa  Asn Ala Gln 
    1460                 1465                 1470             


Gln Asn  Met Pro Pro Gln Met  Met Gly Gly Pro Ile  Gln Ala Ser 
    1475                 1480                 1485             


Ala Glu  Val Ala Gln Gln Gly  Xaa Met Trp Gln Gly  Arg Asn Asp 
    1490                 1495                 1500             


Met Xaa  Tyr Asn Tyr Ala Asn  Arg Gln Ser Xaa Gly  Ser Ala Pro 
    1505                 1510                 1515             


Gln Gly  Pro Ala Tyr His Gly  Val Asn Arg Xaa Asp  Glu Met Leu 
    1520                 1525                 1530             


His Xaa  Asp Gln Arg Ala Asn  His Glu Gly Ser Trp  Pro Ser His 
    1535                 1540                 1545             


Gly Xaa  Arg Gln Pro Pro Tyr  Gly Pro Ser Ala Pro  Val Pro Pro 
    1550                 1555                 1560             


Met Xaa  Arg Pro Pro Pro Ser  Asn Tyr Gln Pro Pro  Pro Ser Met 
    1565                 1570                 1575             


Gln Asn  His Ile Pro Gln Val  Ser Ser Pro Ala Pro  Leu Pro Arg 
    1580                 1585                 1590             


Pro Met  Glu Asn Arg Xaa Ser  Pro Ser Lys Ser Pro  Phe Leu His 
    1595                 1600                 1605             


Ser Gly  Met Lys Met Gln Lys  Ala Gly Pro Pro Val  Pro Ala Ser 
    1610                 1615                 1620             


His Ile  Ala Pro Ala Pro Val  Gln Pro Pro Met Ile  Arg Arg Asp 
    1625                 1630                 1635             


Ile Xaa  Phe Pro Pro Gly Ser  Val Glu Ala Xaa Gln  Pro Val Leu 
    1640                 1645                 1650             


Lys Gln  Arg Arg Arg Leu Xaa  Met Lys Asp Ile Gly  Xaa Pro Glu 
    1655                 1660                 1665             


Ala Trp  Arg Val Met Met Ser  Leu Lys Ser Gly Leu  Leu Ala Glu 
    1670                 1675                 1680             


Ser Xaa  Trp Ala Leu Asp Xaa  Ile Asn Ile Leu Leu  Tyr Asp Asp 
    1685                 1690                 1695             


Asn Ser  Ile Met Xaa Phe Asn  Leu Ser Gln Leu Pro  Gly Leu Leu 
    1700                 1705                 1710             


Glu Leu  Leu Val Glu Tyr Phe  Arg Arg Cys Leu Ile  Glu Ile Phe 
    1715                 1720                 1725             


Gly Ile  Leu Lys Glu Tyr Glu  Val Gly Asp Pro Gly  Gln Arg Xaa 
    1730                 1735                 1740             


Leu Leu  Asp Pro Gly Arg Phe  Ser Lys Val Ser Ser  Pro Ala Pro 
    1745                 1750                 1755             


Met Glu  Gly Gly Glu Glu Glu  Glu Glu Leu Leu Gly  Pro Lys Leu 
    1760                 1765                 1770             


Glu Glu  Glu Glu Glu Glu Glu  Val Val Glu Asn Asp  Glu Glu Ile 
    1775                 1780                 1785             


Ala Phe  Ser Gly Lys Asp Lys  Pro Ala Ser Glu Asn  Ser Glu Glu 
    1790                 1795                 1800             


Lys Leu  Ile Ser Lys Phe Asp  Lys Leu Pro Val Lys  Ile Val Gln 
    1805                 1810                 1815             


Lys Asn  Asp Pro Phe Val Val  Asp Cys Ser Asp Lys  Leu Gly Arg 
    1820                 1825                 1830             


Val Gln  Glu Phe Asp Ser Gly  Leu Leu His Trp Arg  Ile Gly Gly 
    1835                 1840                 1845             


Gly Asp  Xaa Xaa Glu His Ile  Gln Xaa His Phe Glu  Ser Lys Xaa 
    1850                 1855                 1860             


Glu Leu  Leu Pro Ser Arg Pro  His Ala Pro Cys Pro  Pro Ala Pro 
    1865                 1870                 1875             


Arg Lys  His Val Xaa Xaa Ala  Glu Gly Xaa Pro Gly  Xaa Xaa Asp 
    1880                 1885                 1890             


Gln Glu  Gly Pro Pro Pro Asp  Gly Pro Pro Glu Lys  Arg Ile Xaa 
    1895                 1900                 1905             


Ala Xaa  Met Asp Asp Met Leu  Ser Xaa Arg Ser Ser  Xaa Leu Xaa 
    1910                 1915                 1920             


Glu Asp  Gly Ala Lys Ser Ser  Glu Ala Ile Lys Glu  Ser Ser Lys 
    1925                 1930                 1935             


Phe Pro  Phe Gly Ile Ser Pro  Ala Gln Ser His Arg  Asn Ile Lys 
    1940                 1945                 1950             


Ile Leu  Glu Asp Glu Pro His  Ser Lys Asp Glu Xaa  Pro Leu Cys 
    1955                 1960                 1965             


Xaa Leu  Leu Asp Trp Gln Asp  Ser Leu Ala Lys Arg  Cys Val Cys 
    1970                 1975                 1980             


Val Ser  Asn Xaa Ile Arg Ser  Leu Ser Phe Val Pro  Gly Asn Asp 
    1985                 1990                 1995             


Phe Glu  Met Ser Lys His Pro  Gly Leu Leu Leu Ile  Leu Gly Lys 
    2000                 2005                 2010             


Leu Ile  Leu Leu His His Lys  His Pro Glu Arg Lys  Gln Ala Pro 
    2015                 2020                 2025             


Leu Xaa  Tyr Glu Lys Glu Glu  Glu Gln Asp Gln Gly  Val Ser Cys 
    2030                 2035                 2040             


Asn Lys  Val Glu Trp Trp Trp  Asp Cys Leu Glu Met  Leu Arg Glu 
    2045                 2050                 2055             


Asn Xaa  Leu Val Xaa Leu Ala  Asn Ile Ser Gly Gln  Leu Asp Leu 
    2060                 2065                 2070             


Ser Pro  Tyr Pro Glu Ser Ile  Cys Leu Pro Val Leu  Asp Gly Leu 
    2075                 2080                 2085             


Leu His  Trp Ala Val Cys Pro  Ser Ala Glu Ala Gln  Asp Pro Phe 
    2090                 2095                 2100             


Ser Xaa  Leu Gly Pro Asn Ala  Val Leu Ser Pro Gln  Arg Leu Val 
    2105                 2110                 2115             


Leu Glu  Xaa Leu Ser Lys Leu  Ser Ile Gln Asp Asn  Asn Val Asp 
    2120                 2125                 2130             


Leu Ile  Leu Ala Xaa Pro Pro  Phe Ser Arg Leu Glu  Lys Leu Tyr 
    2135                 2140                 2145             


Ser Xaa  Met Val Arg Phe Leu  Ser Asp Arg Lys Asn  Pro Val Cys 
    2150                 2155                 2160             


Arg Glu  Met Ala Val Val Leu  Leu Ala Asn Leu Ala  Gln Gly Asp 
    2165                 2170                 2175             


Ser Leu  Ala Ala Arg Ala Ile  Ala Val Gln Lys Gly  Ser Ile Gly 
    2180                 2185                 2190             


Asn Leu  Leu Gly Phe Leu Glu  Asp Ser Leu Ala Ala  Xaa Gln Phe 
    2195                 2200                 2205             


Gln Gln  Ser Gln Ala Ser Leu  Leu His Met Gln Asn  Pro Pro Phe 
    2210                 2215                 2220             


Glu Pro  Xaa Ser Val Asp Met  Met Arg Arg Ala Ala  Arg Ala Leu 
    2225                 2230                 2235             


Leu Ala  Leu Ala Lys Val Asp  Glu Asn His Ser Glu  Phe Xaa Leu 
    2240                 2245                 2250             


Tyr Glu  Ser Arg Leu Leu Asp  Ile Ser Val Ser Pro  Leu Met Asn 
    2255                 2260                 2265             


Ser Leu  Val Ser Gln Val Ile  Cys Asp Val Leu Phe  Leu Ile Gly 
    2270                 2275                 2280             


Gln Ser  
    2285 


<210> 3094
<211> 123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 3094
Met Asp Gln Met Gly Lys Met Arg Pro Gln Pro Tyr Gly Gly Xaa Asn 
1               5                   10                  15      


Pro Tyr Ser Gln Gln Gln Gly Pro Pro Ser Gly Pro Gln Gln Gly His 
            20                  25                  30          


Gly Tyr Pro Gly Gln Pro Tyr Gly Ser Gln Xaa Pro Gln Arg Tyr Pro 
        35                  40                  45              


Met Xaa Met Gln Gly Arg Ala Gln Ser Ala Met Gly Gly Leu Ser Tyr 
    50                  55                  60                  


Xaa Gln Gln Ile Pro Pro Tyr Gly Gln Gln Gly Pro Ser Gly Tyr Gly 
65                  70                  75                  80  


Gln Gln Gly Gln Xaa Pro Tyr Tyr Asn Gln Gln Ser Pro His Pro Gln 
                85                  90                  95      


Gln Gln Gln Pro Pro Tyr Ser Gln Gln Pro Pro Ser Gln Xaa Pro His 
            100                 105                 110         


Ala Gln Pro Ser Tyr Gln Gln Gln Pro Gln Ser 
        115                 120             


<210> 3095
<211> 206
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<400> 3095
Met Asp Gln Met Gly Lys Met Arg Pro Gln Pro Tyr Gly Gly Xaa Asn 
1               5                   10                  15      


Pro Tyr Ser Gln Gln Gln Gly Pro Pro Ser Gly Pro Gln Gln Gly His 
            20                  25                  30          


Gly Tyr Pro Gly Gln Pro Tyr Gly Ser Gln Xaa Pro Gln Arg Tyr Pro 
        35                  40                  45              


Met Xaa Met Gln Gly Arg Ala Gln Ser Ala Met Gly Gly Leu Ser Tyr 
    50                  55                  60                  


Xaa Gln Gln Ile Pro Pro Tyr Gly Gln Gln Gly Pro Ser Gly Tyr Gly 
65                  70                  75                  80  


Gln Gln Gly Gln Xaa Pro Tyr Tyr Asn Gln Gln Ser Pro His Pro Gln 
                85                  90                  95      


Gln Gln Gln Pro Pro Tyr Ser Gln Gln Pro Pro Ser Gln Xaa Pro His 
            100                 105                 110         


Ala Gln Pro Ser Tyr Gln Gln Gln Pro Gln Ser Gln Pro Pro Gln Leu 
        115                 120                 125             


Gln Ser Ser Gln Pro Pro Tyr Ser Gln Gln Pro Ser Gln Pro Pro His 
    130                 135                 140                 


Gln Gln Ser Pro Ala Pro Tyr Pro Ser Gln Gln Ser Xaa Xaa Gln Gln 
145                 150                 155                 160 


His Pro Gln Ser Gln Pro Pro Tyr Ser Gln Pro Gln Ala Gln Ser Pro 
                165                 170                 175     


Tyr Gln Gln Gln Gln Pro Gln Gln Pro Ala Pro Ser Xaa Leu Ser Gln 
            180                 185                 190         


Gln Ala Ala Tyr Pro Gln Pro Gln Ser Gln Gln Ser Gln Gln 
        195                 200                 205     


<210> 3096
<211> 1141
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<400> 3096
Met Asp Gln Met Gly Lys Met Arg Pro Gln Pro Tyr Gly Gly Xaa Asn 
1               5                   10                  15      


Pro Tyr Ser Gln Gln Gln Gly Pro Pro Ser Gly Pro Gln Gln Gly His 
            20                  25                  30          


Gly Tyr Pro Gly Gln Pro Tyr Gly Ser Gln Xaa Pro Gln Arg Tyr Pro 
        35                  40                  45              


Met Xaa Met Gln Gly Arg Ala Gln Ser Ala Met Gly Gly Leu Ser Tyr 
    50                  55                  60                  


Xaa Gln Gln Ile Pro Pro Tyr Gly Gln Gln Gly Pro Ser Gly Tyr Gly 
65                  70                  75                  80  


Gln Gln Gly Gln Xaa Pro Tyr Tyr Asn Gln Gln Ser Pro His Pro Gln 
                85                  90                  95      


Gln Gln Gln Pro Pro Tyr Ser Gln Gln Pro Pro Ser Gln Xaa Pro His 
            100                 105                 110         


Ala Gln Pro Ser Tyr Gln Gln Gln Pro Gln Ser Gln Pro Pro Gln Leu 
        115                 120                 125             


Gln Ser Ser Gln Pro Pro Tyr Ser Gln Gln Pro Ser Gln Pro Pro His 
    130                 135                 140                 


Gln Gln Ser Pro Ala Pro Tyr Pro Ser Gln Gln Ser Xaa Xaa Gln Gln 
145                 150                 155                 160 


His Pro Gln Ser Gln Pro Pro Tyr Ser Gln Pro Gln Ala Gln Ser Pro 
                165                 170                 175     


Tyr Gln Gln Gln Gln Pro Gln Gln Pro Ala Pro Ser Xaa Leu Ser Gln 
            180                 185                 190         


Gln Ala Ala Tyr Pro Gln Pro Gln Ser Gln Gln Ser Gln Gln Xaa Ala 
        195                 200                 205             


Tyr Ser Gln Gln Arg Phe Pro Pro Pro Gln Glu Leu Ser Gln Asp Ser 
    210                 215                 220                 


Phe Gly Ser Gln Ala Ser Ser Ala Pro Ser Met Xaa Ser Ser Lys Gly 
225                 230                 235                 240 


Gly Gln Glu Asp Met Asn Leu Ser Leu Gln Ser Arg Pro Ser Ser Leu 
                245                 250                 255     


Pro Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Met Gly Xaa Glu Gly 
            260                 265                 270         


Ala Leu Ser Pro Gly Val Ser Xaa Ser Gly Ile Ser Ser Ser Gln Gly 
        275                 280                 285             


Glu Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Xaa Ser Pro 
    290                 295                 300                 


His Leu Pro Gly Ile Arg Gly Pro Ser Pro Ser Pro Val Gly Ser Pro 
305                 310                 315                 320 


Ala Ser Val Ala Gln Ser Arg Ser Gly Pro Leu Ser Pro Ala Ala Val 
                325                 330                 335     


Pro Gly Asn Gln Met Pro Pro Arg Pro Pro Ser Gly Gln Ser Asp Ser 
            340                 345                 350         


Ile Met His Pro Ser Met Asn Gln Ser Ser Ile Ala Gln Asp Arg Gly 
        355                 360                 365             


Tyr Met Gln Arg Asn Pro Gln Met Pro Gln Tyr Ser Ser Pro Gln Pro 
    370                 375                 380                 


Gly Ser Ala Leu Ser Pro Arg Gln Pro Ser Gly Gly Gln Ile His Xaa 
385                 390                 395                 400 


Gly Met Gly Ser Tyr Gln Gln Asn Ser Met Gly Ser Tyr Gly Pro Gln 
                405                 410                 415     


Gly Gly Gln Tyr Gly Pro Gln Gly Gly Tyr Pro Arg Gln Pro Asn Tyr 
            420                 425                 430         


Asn Ala Leu Pro Asn Ala Asn Tyr Pro Ser Ala Gly Met Ala Gly Gly 
        435                 440                 445             


Ile Asn Pro Met Gly Ala Gly Gly Gln Met His Gly Gln Pro Gly Ile 
    450                 455                 460                 


Pro Pro Tyr Gly Xaa Leu Pro Pro Gly Arg Met Ser His Ala Ser Met 
465                 470                 475                 480 


Gly Asn Arg Pro Tyr Gly Pro Asn Met Ala Asn Ala Xaa Ser Gly Trp 
                485                 490                 495     


Val Arg Asp Val Ser Pro Pro Gly Gly Met Asn Arg Lys Xaa Gln Glu 
            500                 505                 510         


Xaa Ala Val Ala Met His Val Ala Ala Asn Ser Ile Gln Asn Arg Pro 
        515                 520                 525             


Pro Gly Tyr Pro Asn Met Asn Gln Gly Gly Met Met Gly Xaa Gly Pro 
    530                 535                 540                 


Pro Tyr Gly Gln Gly Ile Asn Ser Met Ala Gly Met Ile Asn Pro Gln 
545                 550                 555                 560 


Gly Pro Pro Tyr Ser Met Gly Gly Xaa Met Ala Asn Asn Ser Ala Gly 
                565                 570                 575     


Met Ala Ala Ser Pro Glu Met Met Gly Leu Gly Asp Val Lys Leu Xaa 
            580                 585                 590         


Pro Ala Xaa Lys Met Asn Asn Lys Ala Asp Gly Xaa Pro Lys Xaa Glu 
        595                 600                 605             


Ser Lys Ser Lys Lys Ser Ser Ser Ser Xaa Xaa Xaa Asn Glu Lys Ile 
    610                 615                 620                 


Xaa Lys Leu Tyr Glu Leu Gly Gly Glu Pro Glu Arg Lys Met Trp Val 
625                 630                 635                 640 


Asp Arg Tyr Leu Ala Phe Xaa Glu Glu Lys Ala Met Gly Met Xaa Asn 
                645                 650                 655     


Leu Pro Ala Val Gly Arg Lys Pro Leu Asp Leu Tyr Arg Leu Tyr Val 
            660                 665                 670         


Ser Val Lys Glu Ile Gly Gly Leu Xaa Gln Val Asn Lys Asn Lys Lys 
        675                 680                 685             


Trp Arg Glu Leu Ala Xaa Asn Leu Asn Val Gly Xaa Ser Ser Ser Ala 
    690                 695                 700                 


Ala Ser Ser Leu Lys Lys Gln Tyr Ile Gln Cys Leu Tyr Ala Phe Glu 
705                 710                 715                 720 


Cys Lys Ile Glu Arg Gly Glu Asp Pro Pro Pro Asp Ile Phe Ala Ala 
                725                 730                 735     


Ala Asp Ser Lys Lys Ser Gln Pro Lys Ile Gln Pro Pro Ser Pro Ala 
            740                 745                 750         


Gly Ser Gly Ser Met Gln Gly Pro Gln Xaa Pro Gln Ser Xaa Ser Ser 
        755                 760                 765             


Ser Met Ala Glu Gly Gly Asp Leu Lys Pro Pro Xaa Pro Ala Ser Xaa 
    770                 775                 780                 


Pro His Ser Gln Ile Pro Pro Leu Pro Gly Met Ser Arg Ser Asn Ser 
785                 790                 795                 800 


Val Gly Ile Gln Asp Ala Phe Asn Asp Gly Ser Asp Ser Xaa Phe Gln 
                805                 810                 815     


Lys Arg Asn Ser Met Xaa Pro Asn Pro Gly Tyr Gln Pro Ser Met Asn 
            820                 825                 830         


Xaa Ser Asp Met Met Gly Arg Met Ser Tyr Glu Pro Asn Lys Asp Pro 
        835                 840                 845             


Tyr Gly Ser Met Arg Lys Ala Pro Gly Ser Asp Pro Phe Met Ser Ser 
    850                 855                 860                 


Gly Gln Gly Pro Asn Gly Gly Met Gly Asp Pro Tyr Ser Arg Ala Ala 
865                 870                 875                 880 


Gly Pro Gly Leu Gly Asn Val Ala Met Gly Pro Arg Gln His Tyr Pro 
                885                 890                 895     


Tyr Gly Gly Pro Tyr Asp Arg Val Arg Xaa Glu Pro Gly Ile Gly Pro 
            900                 905                 910         


Glu Gly Asn Met Ser Xaa Gly Ala Pro Gln Pro Asn Leu Met Pro Ser 
        915                 920                 925             


Asn Pro Asp Ser Gly Met Tyr Ser Pro Ser Arg Tyr Pro Pro Gln Gln 
    930                 935                 940                 


Gln Gln Gln Gln Gln Gln Arg His Asp Ser Tyr Gly Asn Gln Phe Ser 
945                 950                 955                 960 


Xaa Gln Gly Xaa Pro Ser Gly Ser Pro Phe Pro Ser Gln Gln Xaa Xaa 
                965                 970                 975     


Met Tyr Gln Gln Gln Gln Gln Asn Tyr Lys Arg Pro Met Asp Gly Xaa 
            980                 985                 990         


Tyr Gly Pro Pro Ala Lys Arg His  Glu Gly Glu Met Tyr  Ser Val Pro 
        995                 1000                 1005             


Tyr Ser  Xaa Gly Gln Gly Gln  Pro Gln Gln Gln Gln  Leu Pro Pro 
    1010                 1015                 1020             


Ala Gln  Pro Gln Pro Ala Ser  Gln Gln Gln Ala Ala  Gln Pro Ser 
    1025                 1030                 1035             


Pro Gln  Gln Asp Val Tyr Asn  Gln Tyr Gly Asn Ala  Tyr Pro Ala 
    1040                 1045                 1050             


Xaa Ala  Xaa Ala Ala Xaa Glu  Arg Arg Pro Ala Gly  Gly Pro Gln 
    1055                 1060                 1065             


Asn Gln  Phe Pro Phe Gln Phe  Gly Arg Asp Arg Val  Ser Ala Pro 
    1070                 1075                 1080             


Pro Gly  Xaa Asn Ala Gln Gln  Asn Met Pro Pro Gln  Met Met Gly 
    1085                 1090                 1095             


Gly Pro  Ile Gln Ala Ser Ala  Glu Val Ala Gln Gln  Gly Xaa Met 
    1100                 1105                 1110             


Trp Gln  Gly Arg Asn Asp Met  Xaa Tyr Asn Tyr Ala  Asn Arg Gln 
    1115                 1120                 1125             


Ser Xaa  Ala Leu Pro Pro Arg  Ala Pro Pro Ile Met  Ala 
    1130                 1135                 1140     


<210> 3097
<211> 1901
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1145)..(1145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1276)..(1276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1282)..(1282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1306)..(1306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1319)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1359)..(1359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1467)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1479)..(1479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1499)..(1500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1504)..(1504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1507)..(1508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1524)..(1524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1526)..(1526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1533)..(1533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1537)..(1537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1539)..(1539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1581)..(1581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1585)..(1585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1603)..(1603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1676)..(1676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1679)..(1679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1737)..(1737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1766)..(1766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1822)..(1822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1842)..(1842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1868)..(1868)
<223> Selenocysteine

<400> 3097
Met Asp Gln Met Gly Lys Met Arg Pro Gln Pro Tyr Gly Gly Xaa Asn 
1               5                   10                  15      


Pro Tyr Ser Gln Gln Gln Gly Pro Pro Ser Gly Pro Gln Gln Gly His 
            20                  25                  30          


Gly Tyr Pro Gly Gln Pro Tyr Gly Ser Gln Xaa Pro Gln Arg Tyr Pro 
        35                  40                  45              


Met Xaa Met Gln Gly Arg Ala Gln Ser Ala Met Gly Gly Leu Ser Tyr 
    50                  55                  60                  


Xaa Gln Gln Ile Pro Pro Tyr Gly Gln Gln Gly Pro Ser Gly Tyr Gly 
65                  70                  75                  80  


Gln Gln Gly Gln Xaa Pro Tyr Tyr Asn Gln Gln Ser Pro His Pro Gln 
                85                  90                  95      


Gln Gln Gln Pro Pro Tyr Ser Gln Gln Pro Pro Ser Gln Xaa Pro His 
            100                 105                 110         


Ala Gln Pro Ser Tyr Gln Gln Gln Pro Gln Ser Gln Pro Pro Gln Leu 
        115                 120                 125             


Gln Ser Ser Gln Pro Pro Tyr Ser Gln Gln Pro Ser Gln Pro Pro His 
    130                 135                 140                 


Gln Gln Ser Pro Ala Pro Tyr Pro Ser Gln Gln Ser Xaa Xaa Gln Gln 
145                 150                 155                 160 


His Pro Gln Ser Gln Pro Pro Tyr Ser Gln Pro Gln Ala Gln Ser Pro 
                165                 170                 175     


Tyr Gln Gln Gln Gln Pro Gln Gln Pro Ala Pro Ser Xaa Leu Ser Gln 
            180                 185                 190         


Gln Ala Ala Tyr Pro Gln Pro Gln Ser Gln Gln Ser Gln Gln Xaa Ala 
        195                 200                 205             


Tyr Ser Gln Gln Arg Phe Pro Pro Pro Gln Glu Leu Ser Gln Asp Ser 
    210                 215                 220                 


Phe Gly Ser Gln Ala Ser Ser Ala Pro Ser Met Xaa Ser Ser Lys Gly 
225                 230                 235                 240 


Gly Gln Glu Asp Met Asn Leu Ser Leu Gln Ser Arg Pro Ser Ser Leu 
                245                 250                 255     


Pro Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Met Gly Xaa Glu Gly 
            260                 265                 270         


Ala Leu Ser Pro Gly Val Ser Xaa Ser Gly Ile Ser Ser Ser Gln Gly 
        275                 280                 285             


Glu Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Xaa Ser Pro 
    290                 295                 300                 


His Leu Pro Gly Ile Arg Gly Pro Ser Pro Ser Pro Val Gly Ser Pro 
305                 310                 315                 320 


Ala Ser Val Ala Gln Ser Arg Ser Gly Pro Leu Ser Pro Ala Ala Val 
                325                 330                 335     


Pro Gly Asn Gln Met Pro Pro Arg Pro Pro Ser Gly Gln Ser Asp Ser 
            340                 345                 350         


Ile Met His Pro Ser Met Asn Gln Ser Ser Ile Ala Gln Asp Arg Gly 
        355                 360                 365             


Tyr Met Gln Arg Asn Pro Gln Met Pro Gln Tyr Ser Ser Pro Gln Pro 
    370                 375                 380                 


Gly Ser Ala Leu Ser Pro Arg Gln Pro Ser Gly Gly Gln Ile His Xaa 
385                 390                 395                 400 


Gly Met Gly Ser Tyr Gln Gln Asn Ser Met Gly Ser Tyr Gly Pro Gln 
                405                 410                 415     


Gly Gly Gln Tyr Gly Pro Gln Gly Gly Tyr Pro Arg Gln Pro Asn Tyr 
            420                 425                 430         


Asn Ala Leu Pro Asn Ala Asn Tyr Pro Ser Ala Gly Met Ala Gly Gly 
        435                 440                 445             


Ile Asn Pro Met Gly Ala Gly Gly Gln Met His Gly Gln Pro Gly Ile 
    450                 455                 460                 


Pro Pro Tyr Gly Xaa Leu Pro Pro Gly Arg Met Ser His Ala Ser Met 
465                 470                 475                 480 


Gly Asn Arg Pro Tyr Gly Pro Asn Met Ala Asn Met Pro Pro Gln Val 
                485                 490                 495     


Gly Ser Gly Met Cys Pro Pro Pro Gly Gly Met Asn Arg Lys Xaa Gln 
            500                 505                 510         


Glu Xaa Ala Val Ala Met His Val Ala Ala Asn Ser Ile Gln Asn Arg 
        515                 520                 525             


Pro Pro Gly Tyr Pro Asn Met Asn Gln Gly Gly Met Met Gly Xaa Gly 
    530                 535                 540                 


Pro Pro Tyr Gly Gln Gly Ile Asn Ser Met Ala Gly Met Ile Asn Pro 
545                 550                 555                 560 


Gln Gly Pro Pro Tyr Ser Met Gly Gly Xaa Met Ala Asn Asn Ser Ala 
                565                 570                 575     


Gly Met Ala Ala Ser Pro Glu Met Met Gly Leu Gly Asp Val Lys Leu 
            580                 585                 590         


Xaa Pro Ala Xaa Lys Met Asn Asn Lys Ala Asp Gly Xaa Pro Lys Xaa 
        595                 600                 605             


Glu Ser Lys Ser Lys Lys Ser Ser Ser Ser Xaa Xaa Xaa Asn Glu Lys 
    610                 615                 620                 


Ile Xaa Lys Leu Tyr Glu Leu Gly Gly Glu Pro Glu Arg Lys Met Trp 
625                 630                 635                 640 


Val Asp Arg Tyr Leu Ala Phe Xaa Glu Glu Lys Ala Met Gly Met Xaa 
                645                 650                 655     


Asn Leu Pro Ala Val Gly Arg Lys Pro Leu Asp Leu Tyr Arg Leu Tyr 
            660                 665                 670         


Val Ser Val Lys Glu Ile Gly Gly Leu Xaa Gln Val Asn Lys Asn Lys 
        675                 680                 685             


Lys Trp Arg Glu Leu Ala Xaa Asn Leu Asn Val Gly Xaa Ser Ser Ser 
    690                 695                 700                 


Ala Ala Ser Ser Leu Lys Lys Gln Tyr Ile Gln Cys Leu Tyr Ala Phe 
705                 710                 715                 720 


Glu Cys Lys Ile Glu Arg Gly Glu Asp Pro Pro Pro Asp Ile Phe Ala 
                725                 730                 735     


Ala Ala Asp Ser Lys Lys Ser Gln Pro Lys Ile Gln Pro Pro Ser Pro 
            740                 745                 750         


Ala Gly Ser Gly Ser Met Gln Gly Pro Gln Xaa Pro Gln Ser Xaa Ser 
        755                 760                 765             


Ser Ser Met Ala Glu Gly Gly Asp Leu Lys Pro Pro Xaa Pro Ala Ser 
    770                 775                 780                 


Xaa Pro His Ser Gln Ile Pro Pro Leu Pro Gly Met Arg Ser Asn Ser 
785                 790                 795                 800 


Val Gly Ile Gln Asp Ala Phe Asn Asp Gly Ser Asp Ser Xaa Phe Gln 
                805                 810                 815     


Lys Arg Asn Ser Met Xaa Pro Asn Pro Gly Tyr Gln Pro Ser Met Asn 
            820                 825                 830         


Xaa Ser Asp Met Met Gly Arg Met Ser Tyr Glu Pro Asn Lys Asp Pro 
        835                 840                 845             


Tyr Gly Ser Met Arg Lys Ala Pro Gly Ser Asp Pro Phe Met Ser Ser 
    850                 855                 860                 


Gly Gln Gly Pro Asn Gly Gly Met Gly Asp Pro Tyr Ser Arg Ala Ala 
865                 870                 875                 880 


Gly Pro Gly Leu Gly Asn Val Ala Met Gly Pro Arg Gln His Tyr Pro 
                885                 890                 895     


Tyr Gly Gly Pro Tyr Asp Arg Val Arg Xaa Glu Pro Gly Ile Gly Pro 
            900                 905                 910         


Glu Gly Asn Met Ser Xaa Gly Ala Pro Gln Pro Asn Leu Met Pro Ser 
        915                 920                 925             


Asn Pro Asp Ser Gly Met Tyr Ser Pro Ser Arg Tyr Pro Pro Gln Gln 
    930                 935                 940                 


Gln Gln Gln Gln Gln Gln Arg His Asp Ser Tyr Gly Asn Gln Phe Ser 
945                 950                 955                 960 


Xaa Gln Gly Xaa Pro Ser Gly Ser Pro Phe Pro Ser Gln Gln Xaa Xaa 
                965                 970                 975     


Met Tyr Gln Gln Gln Gln Gln Asn Tyr Lys Arg Pro Met Asp Gly Xaa 
            980                 985                 990         


Tyr Gly Pro Pro Ala Lys Arg His  Glu Gly Glu Met Tyr  Ser Val Pro 
        995                 1000                 1005             


Tyr Ser  Xaa Gly Gln Gly Gln  Pro Gln Gln Gln Gln  Leu Pro Pro 
    1010                 1015                 1020             


Ala Gln  Pro Gln Pro Ala Ser  Gln Gln Gln Ala Ala  Gln Pro Ser 
    1025                 1030                 1035             


Pro Gln  Gln Asp Val Tyr Asn  Gln Tyr Gly Asn Ala  Tyr Pro Ala 
    1040                 1045                 1050             


Xaa Ala  Xaa Ala Ala Xaa Glu  Arg Arg Pro Ala Gly  Gly Pro Gln 
    1055                 1060                 1065             


Asn Gln  Phe Pro Phe Gln Phe  Gly Arg Asp Arg Val  Ser Ala Pro 
    1070                 1075                 1080             


Pro Gly  Xaa Asn Ala Gln Gln  Asn Met Pro Pro Gln  Met Met Gly 
    1085                 1090                 1095             


Gly Pro  Ile Gln Ala Ser Ala  Glu Val Ala Gln Gln  Gly Xaa Met 
    1100                 1105                 1110             


Trp Gln  Gly Arg Asn Asp Met  Xaa Tyr Asn Tyr Ala  Asn Arg Gln 
    1115                 1120                 1125             


Ser Xaa  Gly Ser Ala Pro Gln  Gly Pro Ala Tyr His  Gly Val Asn 
    1130                 1135                 1140             


Arg Xaa  Asp Glu Met Leu His  Xaa Asp Gln Arg Ala  Asn His Glu 
    1145                 1150                 1155             


Gly Ser  Trp Pro Ser His Gly  Xaa Arg Gln Pro Pro  Tyr Gly Pro 
    1160                 1165                 1170             


Ser Ala  Pro Val Pro Pro Met  Xaa Arg Pro Pro Pro  Ser Asn Tyr 
    1175                 1180                 1185             


Gln Pro  Pro Pro Ser Met Gln  Asn His Ile Pro Gln  Val Ser Ser 
    1190                 1195                 1200             


Pro Ala  Pro Leu Pro Arg Pro  Met Glu Asn Arg Xaa  Ser Pro Ser 
    1205                 1210                 1215             


Lys Ser  Pro Phe Leu His Ser  Gly Met Lys Met Gln  Lys Ala Gly 
    1220                 1225                 1230             


Pro Pro  Val Pro Ala Ser His  Ile Ala Pro Ala Pro  Val Gln Pro 
    1235                 1240                 1245             


Pro Met  Ile Arg Arg Asp Ile  Xaa Phe Pro Pro Gly  Ser Val Glu 
    1250                 1255                 1260             


Ala Xaa  Gln Pro Val Leu Lys  Gln Arg Arg Arg Leu  Xaa Met Lys 
    1265                 1270                 1275             


Asp Ile  Gly Xaa Pro Glu Ala  Trp Arg Val Met Met  Ser Leu Lys 
    1280                 1285                 1290             


Ser Gly  Leu Leu Ala Glu Ser  Xaa Trp Ala Leu Asp  Xaa Ile Asn 
    1295                 1300                 1305             


Ile Leu  Leu Tyr Asp Asp Asn  Ser Ile Met Xaa Phe  Asn Leu Ser 
    1310                 1315                 1320             


Gln Leu  Pro Gly Leu Leu Glu  Leu Leu Val Glu Tyr  Phe Arg Arg 
    1325                 1330                 1335             


Cys Leu  Ile Glu Ile Phe Gly  Ile Leu Lys Glu Tyr  Glu Val Gly 
    1340                 1345                 1350             


Asp Pro  Gly Gln Arg Xaa Leu  Leu Asp Pro Gly Arg  Phe Ser Lys 
    1355                 1360                 1365             


Val Ser  Ser Pro Ala Pro Met  Glu Gly Gly Glu Glu  Glu Glu Glu 
    1370                 1375                 1380             


Leu Leu  Gly Pro Lys Leu Glu  Glu Glu Glu Glu Glu  Glu Val Val 
    1385                 1390                 1395             


Glu Asn  Asp Glu Glu Ile Ala  Phe Ser Gly Lys Asp  Lys Pro Ala 
    1400                 1405                 1410             


Ser Glu  Asn Ser Glu Glu Lys  Leu Ile Ser Lys Phe  Asp Lys Leu 
    1415                 1420                 1425             


Pro Val  Lys Ile Val Gln Lys  Asn Asp Pro Phe Val  Val Asp Cys 
    1430                 1435                 1440             


Ser Asp  Lys Leu Gly Arg Val  Gln Glu Phe Asp Ser  Gly Leu Leu 
    1445                 1450                 1455             


His Trp  Arg Ile Gly Gly Gly  Asp Xaa Xaa Glu His  Ile Gln Xaa 
    1460                 1465                 1470             


His Phe  Glu Ser Lys Xaa Glu  Leu Leu Pro Ser Arg  Pro His Ala 
    1475                 1480                 1485             


Pro Cys  Pro Pro Ala Pro Arg  Lys His Val Xaa Xaa  Ala Glu Gly 
    1490                 1495                 1500             


Xaa Pro  Gly Xaa Xaa Asp Gln  Glu Gly Pro Pro Pro  Asp Gly Pro 
    1505                 1510                 1515             


Pro Glu  Lys Arg Ile Xaa Ala  Xaa Met Asp Asp Met  Leu Ser Xaa 
    1520                 1525                 1530             


Arg Ser  Ser Xaa Leu Xaa Glu  Asp Gly Ala Lys Ser  Ser Glu Ala 
    1535                 1540                 1545             


Ile Lys  Glu Ser Ser Lys Phe  Pro Phe Gly Ile Ser  Pro Ala Gln 
    1550                 1555                 1560             


Ser His  Arg Asn Ile Lys Ile  Leu Glu Asp Glu Pro  His Ser Lys 
    1565                 1570                 1575             


Asp Glu  Xaa Pro Leu Cys Xaa  Leu Leu Asp Trp Gln  Asp Ser Leu 
    1580                 1585                 1590             


Ala Lys  Arg Cys Val Cys Val  Ser Asn Xaa Ile Arg  Ser Leu Ser 
    1595                 1600                 1605             


Phe Val  Pro Gly Asn Asp Phe  Glu Met Ser Lys His  Pro Gly Leu 
    1610                 1615                 1620             


Leu Leu  Ile Leu Gly Lys Leu  Ile Leu Leu His His  Lys His Pro 
    1625                 1630                 1635             


Glu Arg  Lys Gln Ala Pro Leu  Xaa Tyr Glu Lys Glu  Glu Glu Gln 
    1640                 1645                 1650             


Asp Gln  Gly Val Ser Cys Asn  Lys Val Glu Trp Trp  Trp Asp Cys 
    1655                 1660                 1665             


Leu Glu  Met Leu Arg Glu Asn  Xaa Leu Val Xaa Leu  Ala Asn Ile 
    1670                 1675                 1680             


Ser Gly  Gln Leu Asp Leu Ser  Pro Tyr Pro Glu Ser  Ile Cys Leu 
    1685                 1690                 1695             


Pro Val  Leu Asp Gly Leu Leu  His Trp Ala Val Cys  Pro Ser Ala 
    1700                 1705                 1710             


Glu Ala  Gln Asp Pro Phe Ser  Xaa Leu Gly Pro Asn  Ala Val Leu 
    1715                 1720                 1725             


Ser Pro  Gln Arg Leu Val Leu  Glu Xaa Leu Ser Lys  Leu Ser Ile 
    1730                 1735                 1740             


Gln Asp  Asn Asn Val Asp Leu  Ile Leu Ala Xaa Pro  Pro Phe Ser 
    1745                 1750                 1755             


Arg Leu  Glu Lys Leu Tyr Ser  Xaa Met Val Arg Phe  Leu Ser Asp 
    1760                 1765                 1770             


Arg Lys  Asn Pro Val Cys Arg  Glu Met Ala Val Val  Leu Leu Ala 
    1775                 1780                 1785             


Asn Leu  Ala Gln Gly Asp Ser  Leu Ala Ala Arg Ala  Ile Ala Val 
    1790                 1795                 1800             


Gln Lys  Gly Ser Ile Gly Asn  Leu Leu Gly Phe Leu  Glu Asp Ser 
    1805                 1810                 1815             


Leu Ala  Ala Xaa Gln Phe Gln  Gln Ser Gln Ala Ser  Leu Leu His 
    1820                 1825                 1830             


Met Gln  Asn Pro Pro Phe Glu  Pro Xaa Ser Val Asp  Met Met Arg 
    1835                 1840                 1845             


Arg Ala  Ala Arg Ala Leu Leu  Ala Leu Ala Lys Val  Asp Glu Asn 
    1850                 1855                 1860             


His Ser  Glu Phe Xaa Leu Tyr  Glu Ser Arg Leu Leu  Asp Ile Ser 
    1865                 1870                 1875             


Val Ser  Pro Leu Met Asn Ser  Leu Val Ser Gln Val  Ile Cys Asp 
    1880                 1885                 1890             


Val Leu  Phe Leu Ile Gly Gln  Ser 
    1895                 1900     


<210> 3098
<211> 1902
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1131)..(1131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1152)..(1152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1277)..(1277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1320)..(1320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1360)..(1360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1474)..(1474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1480)..(1480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1500)..(1501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1505)..(1505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1508)..(1509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1525)..(1525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1527)..(1527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1534)..(1534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1538)..(1538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1540)..(1540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1604)..(1604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1647)..(1647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1677)..(1677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1680)..(1680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1722)..(1722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1738)..(1738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1755)..(1755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1767)..(1767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1823)..(1823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1843)..(1843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1869)..(1869)
<223> Selenocysteine

<400> 3098
Met Asp Gln Met Gly Lys Met Arg Pro Gln Pro Tyr Gly Gly Xaa Asn 
1               5                   10                  15      


Pro Tyr Ser Gln Gln Gln Gly Pro Pro Ser Gly Pro Gln Gln Gly His 
            20                  25                  30          


Gly Tyr Pro Gly Gln Pro Tyr Gly Ser Gln Xaa Pro Gln Arg Tyr Pro 
        35                  40                  45              


Met Xaa Met Gln Gly Arg Ala Gln Ser Ala Met Gly Gly Leu Ser Tyr 
    50                  55                  60                  


Xaa Gln Gln Ile Pro Pro Tyr Gly Gln Gln Gly Pro Ser Gly Tyr Gly 
65                  70                  75                  80  


Gln Gln Gly Gln Xaa Pro Tyr Tyr Asn Gln Gln Ser Pro His Pro Gln 
                85                  90                  95      


Gln Gln Gln Pro Pro Tyr Ser Gln Gln Pro Pro Ser Gln Xaa Pro His 
            100                 105                 110         


Ala Gln Pro Ser Tyr Gln Gln Gln Pro Gln Ser Gln Pro Pro Gln Leu 
        115                 120                 125             


Gln Ser Ser Gln Pro Pro Tyr Ser Gln Gln Pro Ser Gln Pro Pro His 
    130                 135                 140                 


Gln Gln Ser Pro Ala Pro Tyr Pro Ser Gln Gln Ser Xaa Xaa Gln Gln 
145                 150                 155                 160 


His Pro Gln Ser Gln Pro Pro Tyr Ser Gln Pro Gln Ala Gln Ser Pro 
                165                 170                 175     


Tyr Gln Gln Gln Gln Pro Gln Gln Pro Ala Pro Ser Xaa Leu Ser Gln 
            180                 185                 190         


Gln Ala Ala Tyr Pro Gln Pro Gln Ser Gln Gln Ser Gln Gln Xaa Ala 
        195                 200                 205             


Tyr Ser Gln Gln Arg Phe Pro Pro Pro Gln Glu Leu Ser Gln Asp Ser 
    210                 215                 220                 


Phe Gly Ser Gln Ala Ser Ser Ala Pro Ser Met Xaa Ser Ser Lys Gly 
225                 230                 235                 240 


Gly Gln Glu Asp Met Asn Leu Ser Leu Gln Ser Arg Pro Ser Ser Leu 
                245                 250                 255     


Pro Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Met Gly Xaa Glu Gly 
            260                 265                 270         


Ala Leu Ser Pro Gly Val Ser Xaa Ser Gly Ile Ser Ser Ser Gln Gly 
        275                 280                 285             


Glu Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Xaa Ser Pro 
    290                 295                 300                 


His Leu Pro Gly Ile Arg Gly Pro Ser Pro Ser Pro Val Gly Ser Pro 
305                 310                 315                 320 


Ala Ser Val Ala Gln Ser Arg Ser Gly Pro Leu Ser Pro Ala Ala Val 
                325                 330                 335     


Pro Gly Asn Gln Met Pro Pro Arg Pro Pro Ser Gly Gln Ser Asp Ser 
            340                 345                 350         


Ile Met His Pro Ser Met Asn Gln Ser Ser Ile Ala Gln Asp Arg Gly 
        355                 360                 365             


Tyr Met Gln Arg Asn Pro Gln Met Pro Gln Tyr Ser Ser Pro Gln Pro 
    370                 375                 380                 


Gly Ser Ala Leu Ser Pro Arg Gln Pro Ser Gly Gly Gln Ile His Xaa 
385                 390                 395                 400 


Gly Met Gly Ser Tyr Gln Gln Asn Ser Met Gly Ser Tyr Gly Pro Gln 
                405                 410                 415     


Gly Gly Gln Tyr Gly Pro Gln Gly Gly Tyr Pro Arg Gln Pro Asn Tyr 
            420                 425                 430         


Asn Ala Leu Pro Asn Ala Asn Tyr Pro Ser Ala Gly Met Ala Gly Gly 
        435                 440                 445             


Ile Asn Pro Met Gly Ala Gly Gly Gln Met His Gly Gln Pro Gly Ile 
    450                 455                 460                 


Pro Pro Tyr Gly Xaa Leu Pro Pro Gly Arg Met Ser His Ala Ser Met 
465                 470                 475                 480 


Gly Asn Arg Pro Tyr Gly Pro Asn Met Ala Asn Met Pro Pro Gln Val 
                485                 490                 495     


Gly Ser Gly Met Cys Pro Pro Pro Gly Gly Met Asn Arg Lys Xaa Gln 
            500                 505                 510         


Glu Xaa Ala Val Ala Met His Val Ala Ala Asn Ser Ile Gln Asn Arg 
        515                 520                 525             


Pro Pro Gly Tyr Pro Asn Met Asn Gln Gly Gly Met Met Gly Xaa Gly 
    530                 535                 540                 


Pro Pro Tyr Gly Gln Gly Ile Asn Ser Met Ala Gly Met Ile Asn Pro 
545                 550                 555                 560 


Gln Gly Pro Pro Tyr Ser Met Gly Gly Xaa Met Ala Asn Asn Ser Ala 
                565                 570                 575     


Gly Met Ala Ala Ser Pro Glu Met Met Gly Leu Gly Asp Val Lys Leu 
            580                 585                 590         


Xaa Pro Ala Xaa Lys Met Asn Asn Lys Ala Asp Gly Xaa Pro Lys Xaa 
        595                 600                 605             


Glu Ser Lys Ser Lys Lys Ser Ser Ser Ser Xaa Xaa Xaa Asn Glu Lys 
    610                 615                 620                 


Ile Xaa Lys Leu Tyr Glu Leu Gly Gly Glu Pro Glu Arg Lys Met Trp 
625                 630                 635                 640 


Val Asp Arg Tyr Leu Ala Phe Xaa Glu Glu Lys Ala Met Gly Met Xaa 
                645                 650                 655     


Asn Leu Pro Ala Val Gly Arg Lys Pro Leu Asp Leu Tyr Arg Leu Tyr 
            660                 665                 670         


Val Ser Val Lys Glu Ile Gly Gly Leu Xaa Gln Val Asn Lys Asn Lys 
        675                 680                 685             


Lys Trp Arg Glu Leu Ala Xaa Asn Leu Asn Val Gly Xaa Ser Ser Ser 
    690                 695                 700                 


Ala Ala Ser Ser Leu Lys Lys Gln Tyr Ile Gln Cys Leu Tyr Ala Phe 
705                 710                 715                 720 


Glu Cys Lys Ile Glu Arg Gly Glu Asp Pro Pro Pro Asp Ile Phe Ala 
                725                 730                 735     


Ala Ala Asp Ser Lys Lys Ser Gln Pro Lys Ile Gln Pro Pro Ser Pro 
            740                 745                 750         


Ala Gly Ser Gly Ser Met Gln Gly Pro Gln Xaa Pro Gln Ser Xaa Ser 
        755                 760                 765             


Ser Ser Met Ala Glu Gly Gly Asp Leu Lys Pro Pro Xaa Pro Ala Ser 
    770                 775                 780                 


Xaa Pro His Ser Gln Ile Pro Pro Leu Pro Gly Met Ser Arg Ser Asn 
785                 790                 795                 800 


Ser Val Gly Ile Gln Asp Ala Phe Asn Asp Gly Ser Asp Ser Xaa Phe 
                805                 810                 815     


Gln Lys Arg Asn Ser Met Xaa Pro Asn Pro Gly Tyr Gln Pro Ser Met 
            820                 825                 830         


Asn Xaa Ser Asp Met Met Gly Arg Met Ser Tyr Glu Pro Asn Lys Asp 
        835                 840                 845             


Pro Tyr Gly Ser Met Arg Lys Ala Pro Gly Ser Asp Pro Phe Met Ser 
    850                 855                 860                 


Ser Gly Gln Gly Pro Asn Gly Gly Met Gly Asp Pro Tyr Ser Arg Ala 
865                 870                 875                 880 


Ala Gly Pro Gly Leu Gly Asn Val Ala Met Gly Pro Arg Gln His Tyr 
                885                 890                 895     


Pro Tyr Gly Gly Pro Tyr Asp Arg Val Arg Xaa Glu Pro Gly Ile Gly 
            900                 905                 910         


Pro Glu Gly Asn Met Ser Xaa Gly Ala Pro Gln Pro Asn Leu Met Pro 
        915                 920                 925             


Ser Asn Pro Asp Ser Gly Met Tyr Ser Pro Ser Arg Tyr Pro Pro Gln 
    930                 935                 940                 


Gln Gln Gln Gln Gln Gln Gln Arg His Asp Ser Tyr Gly Asn Gln Phe 
945                 950                 955                 960 


Ser Xaa Gln Gly Xaa Pro Ser Gly Ser Pro Phe Pro Ser Gln Gln Xaa 
                965                 970                 975     


Xaa Met Tyr Gln Gln Gln Gln Gln Asn Tyr Lys Arg Pro Met Asp Gly 
            980                 985                 990         


Xaa Tyr Gly Pro Pro Ala Lys Arg  His Glu Gly Glu Met  Tyr Ser Val 
        995                 1000                 1005             


Pro Tyr  Ser Xaa Gly Gln Gly  Gln Pro Gln Gln Gln  Gln Leu Pro 
    1010                 1015                 1020             


Pro Ala  Gln Pro Gln Pro Ala  Ser Gln Gln Gln Ala  Ala Gln Pro 
    1025                 1030                 1035             


Ser Pro  Gln Gln Asp Val Tyr  Asn Gln Tyr Gly Asn  Ala Tyr Pro 
    1040                 1045                 1050             


Ala Xaa  Ala Xaa Ala Ala Xaa  Glu Arg Arg Pro Ala  Gly Gly Pro 
    1055                 1060                 1065             


Gln Asn  Gln Phe Pro Phe Gln  Phe Gly Arg Asp Arg  Val Ser Ala 
    1070                 1075                 1080             


Pro Pro  Gly Xaa Asn Ala Gln  Gln Asn Met Pro Pro  Gln Met Met 
    1085                 1090                 1095             


Gly Gly  Pro Ile Gln Ala Ser  Ala Glu Val Ala Gln  Gln Gly Xaa 
    1100                 1105                 1110             


Met Trp  Gln Gly Arg Asn Asp  Met Xaa Tyr Asn Tyr  Ala Asn Arg 
    1115                 1120                 1125             


Gln Ser  Xaa Gly Ser Ala Pro  Gln Gly Pro Ala Tyr  His Gly Val 
    1130                 1135                 1140             


Asn Arg  Xaa Asp Glu Met Leu  His Xaa Asp Gln Arg  Ala Asn His 
    1145                 1150                 1155             


Glu Gly  Ser Trp Pro Ser His  Gly Xaa Arg Gln Pro  Pro Tyr Gly 
    1160                 1165                 1170             


Pro Ser  Ala Pro Val Pro Pro  Met Xaa Arg Pro Pro  Pro Ser Asn 
    1175                 1180                 1185             


Tyr Gln  Pro Pro Pro Ser Met  Gln Asn His Ile Pro  Gln Val Ser 
    1190                 1195                 1200             


Ser Pro  Ala Pro Leu Pro Arg  Pro Met Glu Asn Arg  Xaa Ser Pro 
    1205                 1210                 1215             


Ser Lys  Ser Pro Phe Leu His  Ser Gly Met Lys Met  Gln Lys Ala 
    1220                 1225                 1230             


Gly Pro  Pro Val Pro Ala Ser  His Ile Ala Pro Ala  Pro Val Gln 
    1235                 1240                 1245             


Pro Pro  Met Ile Arg Arg Asp  Ile Xaa Phe Pro Pro  Gly Ser Val 
    1250                 1255                 1260             


Glu Ala  Xaa Gln Pro Val Leu  Lys Gln Arg Arg Arg  Leu Xaa Met 
    1265                 1270                 1275             


Lys Asp  Ile Gly Xaa Pro Glu  Ala Trp Arg Val Met  Met Ser Leu 
    1280                 1285                 1290             


Lys Ser  Gly Leu Leu Ala Glu  Ser Xaa Trp Ala Leu  Asp Xaa Ile 
    1295                 1300                 1305             


Asn Ile  Leu Leu Tyr Asp Asp  Asn Ser Ile Met Xaa  Phe Asn Leu 
    1310                 1315                 1320             


Ser Gln  Leu Pro Gly Leu Leu  Glu Leu Leu Val Glu  Tyr Phe Arg 
    1325                 1330                 1335             


Arg Cys  Leu Ile Glu Ile Phe  Gly Ile Leu Lys Glu  Tyr Glu Val 
    1340                 1345                 1350             


Gly Asp  Pro Gly Gln Arg Xaa  Leu Leu Asp Pro Gly  Arg Phe Ser 
    1355                 1360                 1365             


Lys Val  Ser Ser Pro Ala Pro  Met Glu Gly Gly Glu  Glu Glu Glu 
    1370                 1375                 1380             


Glu Leu  Leu Gly Pro Lys Leu  Glu Glu Glu Glu Glu  Glu Glu Val 
    1385                 1390                 1395             


Val Glu  Asn Asp Glu Glu Ile  Ala Phe Ser Gly Lys  Asp Lys Pro 
    1400                 1405                 1410             


Ala Ser  Glu Asn Ser Glu Glu  Lys Leu Ile Ser Lys  Phe Asp Lys 
    1415                 1420                 1425             


Leu Pro  Val Lys Ile Val Gln  Lys Asn Asp Pro Phe  Val Val Asp 
    1430                 1435                 1440             


Cys Ser  Asp Lys Leu Gly Arg  Val Gln Glu Phe Asp  Ser Gly Leu 
    1445                 1450                 1455             


Leu His  Trp Arg Ile Gly Gly  Gly Asp Xaa Xaa Glu  His Ile Gln 
    1460                 1465                 1470             


Xaa His  Phe Glu Ser Lys Xaa  Glu Leu Leu Pro Ser  Arg Pro His 
    1475                 1480                 1485             


Ala Pro  Cys Pro Pro Ala Pro  Arg Lys His Val Xaa  Xaa Ala Glu 
    1490                 1495                 1500             


Gly Xaa  Pro Gly Xaa Xaa Asp  Gln Glu Gly Pro Pro  Pro Asp Gly 
    1505                 1510                 1515             


Pro Pro  Glu Lys Arg Ile Xaa  Ala Xaa Met Asp Asp  Met Leu Ser 
    1520                 1525                 1530             


Xaa Arg  Ser Ser Xaa Leu Xaa  Glu Asp Gly Ala Lys  Ser Ser Glu 
    1535                 1540                 1545             


Ala Ile  Lys Glu Ser Ser Lys  Phe Pro Phe Gly Ile  Ser Pro Ala 
    1550                 1555                 1560             


Gln Ser  His Arg Asn Ile Lys  Ile Leu Glu Asp Glu  Pro His Ser 
    1565                 1570                 1575             


Lys Asp  Glu Xaa Pro Leu Cys  Xaa Leu Leu Asp Trp  Gln Asp Ser 
    1580                 1585                 1590             


Leu Ala  Lys Arg Cys Val Cys  Val Ser Asn Xaa Ile  Arg Ser Leu 
    1595                 1600                 1605             


Ser Phe  Val Pro Gly Asn Asp  Phe Glu Met Ser Lys  His Pro Gly 
    1610                 1615                 1620             


Leu Leu  Leu Ile Leu Gly Lys  Leu Ile Leu Leu His  His Lys His 
    1625                 1630                 1635             


Pro Glu  Arg Lys Gln Ala Pro  Leu Xaa Tyr Glu Lys  Glu Glu Glu 
    1640                 1645                 1650             


Gln Asp  Gln Gly Val Ser Cys  Asn Lys Val Glu Trp  Trp Trp Asp 
    1655                 1660                 1665             


Cys Leu  Glu Met Leu Arg Glu  Asn Xaa Leu Val Xaa  Leu Ala Asn 
    1670                 1675                 1680             


Ile Ser  Gly Gln Leu Asp Leu  Ser Pro Tyr Pro Glu  Ser Ile Cys 
    1685                 1690                 1695             


Leu Pro  Val Leu Asp Gly Leu  Leu His Trp Ala Val  Cys Pro Ser 
    1700                 1705                 1710             


Ala Glu  Ala Gln Asp Pro Phe  Ser Xaa Leu Gly Pro  Asn Ala Val 
    1715                 1720                 1725             


Leu Ser  Pro Gln Arg Leu Val  Leu Glu Xaa Leu Ser  Lys Leu Ser 
    1730                 1735                 1740             


Ile Gln  Asp Asn Asn Val Asp  Leu Ile Leu Ala Xaa  Pro Pro Phe 
    1745                 1750                 1755             


Ser Arg  Leu Glu Lys Leu Tyr  Ser Xaa Met Val Arg  Phe Leu Ser 
    1760                 1765                 1770             


Asp Arg  Lys Asn Pro Val Cys  Arg Glu Met Ala Val  Val Leu Leu 
    1775                 1780                 1785             


Ala Asn  Leu Ala Gln Gly Asp  Ser Leu Ala Ala Arg  Ala Ile Ala 
    1790                 1795                 1800             


Val Gln  Lys Gly Ser Ile Gly  Asn Leu Leu Gly Phe  Leu Glu Asp 
    1805                 1810                 1815             


Ser Leu  Ala Ala Xaa Gln Phe  Gln Gln Ser Gln Ala  Ser Leu Leu 
    1820                 1825                 1830             


His Met  Gln Asn Pro Pro Phe  Glu Pro Xaa Ser Val  Asp Met Met 
    1835                 1840                 1845             


Arg Arg  Ala Ala Arg Ala Leu  Leu Ala Leu Ala Lys  Val Asp Glu 
    1850                 1855                 1860             


Asn His  Ser Glu Phe Xaa Leu  Tyr Glu Ser Arg Leu  Leu Asp Ile 
    1865                 1870                 1875             


Ser Val  Ser Pro Leu Met Asn  Ser Leu Val Ser Gln  Val Ile Cys 
    1880                 1885                 1890             


Asp Val  Leu Phe Leu Ile Gly  Gln Ser 
    1895                 1900         


<210> 3099
<211> 1903
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1058)..(1058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1123)..(1123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1267)..(1267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1278)..(1278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1308)..(1308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1321)..(1321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1361)..(1361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1469)..(1470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1475)..(1475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1481)..(1481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1501)..(1502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1509)..(1510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1526)..(1526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1528)..(1528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1535)..(1535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1539)..(1539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1541)..(1541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1583)..(1583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1587)..(1587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1605)..(1605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1648)..(1648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1678)..(1678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1681)..(1681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1723)..(1723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1739)..(1739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1756)..(1756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1768)..(1768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1824)..(1824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1844)..(1844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1870)..(1870)
<223> Selenocysteine

<400> 3099
Ser Pro Met Asp Gln Met Gly Lys Met Arg Pro Gln Pro Tyr Gly Gly 
1               5                   10                  15      


Xaa Asn Pro Tyr Ser Gln Gln Gln Gly Pro Pro Ser Gly Pro Gln Gln 
            20                  25                  30          


Gly His Gly Tyr Pro Gly Gln Pro Tyr Gly Ser Gln Xaa Pro Gln Arg 
        35                  40                  45              


Tyr Pro Met Xaa Met Gln Gly Arg Ala Gln Ser Ala Met Gly Gly Leu 
    50                  55                  60                  


Ser Tyr Xaa Gln Gln Ile Pro Pro Tyr Gly Gln Gln Gly Pro Ser Gly 
65                  70                  75                  80  


Tyr Gly Gln Gln Gly Gln Xaa Pro Tyr Tyr Asn Gln Gln Ser Pro His 
                85                  90                  95      


Pro Gln Gln Gln Gln Pro Pro Tyr Ser Gln Gln Pro Pro Ser Gln Xaa 
            100                 105                 110         


Pro His Ala Gln Pro Ser Tyr Gln Gln Gln Pro Gln Ser Gln Pro Pro 
        115                 120                 125             


Gln Leu Gln Ser Ser Gln Pro Pro Tyr Ser Gln Gln Pro Ser Gln Pro 
    130                 135                 140                 


Pro His Gln Gln Ser Pro Ala Pro Tyr Pro Ser Gln Gln Ser Xaa Xaa 
145                 150                 155                 160 


Gln Gln His Pro Gln Ser Gln Pro Pro Tyr Ser Gln Pro Gln Ala Gln 
                165                 170                 175     


Ser Pro Tyr Gln Gln Gln Gln Pro Gln Gln Pro Ala Pro Ser Xaa Leu 
            180                 185                 190         


Ser Gln Gln Ala Ala Tyr Pro Gln Pro Gln Ser Gln Gln Ser Gln Gln 
        195                 200                 205             


Xaa Ala Tyr Ser Gln Gln Arg Phe Pro Pro Pro Gln Glu Leu Ser Gln 
    210                 215                 220                 


Asp Ser Phe Gly Ser Gln Ala Ser Ser Ala Pro Ser Met Xaa Ser Ser 
225                 230                 235                 240 


Lys Gly Gly Gln Glu Asp Met Asn Leu Ser Leu Gln Ser Arg Pro Ser 
                245                 250                 255     


Ser Leu Pro Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Met Gly Xaa 
            260                 265                 270         


Glu Gly Ala Leu Ser Pro Gly Val Ser Xaa Ser Gly Ile Ser Ser Ser 
        275                 280                 285             


Gln Gly Glu Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Xaa 
    290                 295                 300                 


Ser Pro His Leu Pro Gly Ile Arg Gly Pro Ser Pro Ser Pro Val Gly 
305                 310                 315                 320 


Ser Pro Ala Ser Val Ala Gln Ser Arg Ser Gly Pro Leu Ser Pro Ala 
                325                 330                 335     


Ala Val Pro Gly Asn Gln Met Pro Pro Arg Pro Pro Ser Gly Gln Ser 
            340                 345                 350         


Asp Ser Ile Met His Pro Ser Met Asn Gln Ser Ser Ile Ala Gln Asp 
        355                 360                 365             


Arg Gly Tyr Met Gln Arg Asn Pro Gln Met Pro Gln Tyr Ser Ser Pro 
    370                 375                 380                 


Gln Pro Gly Ser Ala Leu Ser Pro Arg Gln Pro Ser Gly Gly Gln Ile 
385                 390                 395                 400 


His Xaa Gly Met Gly Ser Tyr Gln Gln Asn Ser Met Gly Ser Tyr Gly 
                405                 410                 415     


Pro Gln Gly Gly Gln Tyr Gly Pro Gln Gly Gly Tyr Pro Arg Gln Pro 
            420                 425                 430         


Asn Tyr Asn Ala Leu Pro Asn Ala Asn Tyr Pro Ser Ala Gly Met Ala 
        435                 440                 445             


Gly Gly Ile Asn Pro Met Gly Ala Gly Gly Gln Met His Gly Gln Pro 
    450                 455                 460                 


Gly Ile Pro Pro Tyr Gly Xaa Leu Pro Pro Gly Arg Met Ser His Ala 
465                 470                 475                 480 


Ser Met Gly Asn Arg Pro Tyr Gly Pro Asn Met Ala Asn Met Pro Pro 
                485                 490                 495     


Gln Val Gly Ser Gly Met Cys Pro Pro Pro Gly Gly Met Asn Arg Lys 
            500                 505                 510         


Xaa Gln Glu Xaa Ala Val Ala Met His Val Ala Ala Asn Ser Ile Gln 
        515                 520                 525             


Asn Arg Pro Pro Gly Tyr Pro Asn Met Asn Gln Gly Gly Met Met Gly 
    530                 535                 540                 


Xaa Gly Pro Pro Tyr Gly Gln Gly Ile Asn Ser Met Ala Gly Met Ile 
545                 550                 555                 560 


Asn Pro Gln Gly Pro Pro Tyr Ser Met Gly Gly Xaa Met Ala Asn Asn 
                565                 570                 575     


Ser Ala Gly Met Ala Ala Ser Pro Glu Met Met Gly Leu Gly Asp Val 
            580                 585                 590         


Lys Leu Xaa Pro Ala Xaa Lys Met Asn Asn Lys Ala Asp Gly Xaa Pro 
        595                 600                 605             


Lys Xaa Glu Ser Lys Ser Lys Lys Ser Ser Ser Ser Xaa Xaa Xaa Asn 
    610                 615                 620                 


Glu Lys Ile Xaa Lys Leu Tyr Glu Leu Gly Gly Glu Pro Glu Arg Lys 
625                 630                 635                 640 


Met Trp Val Asp Arg Tyr Leu Ala Phe Xaa Glu Glu Lys Ala Met Gly 
                645                 650                 655     


Met Xaa Asn Leu Pro Ala Val Gly Arg Lys Pro Leu Asp Leu Tyr Arg 
            660                 665                 670         


Leu Tyr Val Ser Val Lys Glu Ile Gly Gly Leu Xaa Gln Val Asn Lys 
        675                 680                 685             


Asn Lys Lys Trp Arg Glu Leu Ala Xaa Asn Leu Asn Val Gly Xaa Ser 
    690                 695                 700                 


Ser Ser Ala Ala Ser Ser Leu Lys Lys Gln Tyr Ile Gln Cys Leu Tyr 
705                 710                 715                 720 


Ala Phe Glu Cys Lys Ile Glu Arg Gly Glu Asp Pro Pro Pro Asp Ile 
                725                 730                 735     


Phe Ala Ala Ala Asp Ser Lys Lys Ser Gln Pro Lys Ile Gln Pro Pro 
            740                 745                 750         


Ser Pro Ala Gly Ser Gly Ser Met Gln Gly Pro Gln Xaa Pro Gln Ser 
        755                 760                 765             


Xaa Ser Ser Ser Met Ala Glu Gly Gly Asp Leu Lys Pro Pro Xaa Pro 
    770                 775                 780                 


Ala Ser Xaa Pro His Ser Gln Ile Pro Pro Leu Pro Gly Met Arg Ser 
785                 790                 795                 800 


Asn Ser Val Gly Ile Gln Asp Ala Phe Asn Asp Gly Ser Asp Ser Xaa 
                805                 810                 815     


Phe Gln Lys Arg Asn Ser Met Xaa Pro Asn Pro Gly Tyr Gln Pro Ser 
            820                 825                 830         


Met Asn Xaa Ser Asp Met Met Gly Arg Met Ser Tyr Glu Pro Asn Lys 
        835                 840                 845             


Asp Pro Tyr Gly Ser Met Arg Lys Ala Pro Gly Ser Asp Pro Phe Met 
    850                 855                 860                 


Ser Ser Gly Gln Gly Pro Asn Gly Gly Met Gly Asp Pro Tyr Ser Arg 
865                 870                 875                 880 


Ala Ala Gly Pro Gly Leu Gly Asn Val Ala Met Gly Pro Arg Gln His 
                885                 890                 895     


Tyr Pro Tyr Gly Gly Pro Tyr Asp Arg Val Arg Xaa Glu Pro Gly Ile 
            900                 905                 910         


Gly Pro Glu Gly Asn Met Ser Xaa Gly Ala Pro Gln Pro Asn Leu Met 
        915                 920                 925             


Pro Ser Asn Pro Asp Ser Gly Met Tyr Ser Pro Ser Arg Tyr Pro Pro 
    930                 935                 940                 


Gln Gln Gln Gln Gln Gln Gln Gln Arg His Asp Ser Tyr Gly Asn Gln 
945                 950                 955                 960 


Phe Ser Xaa Gln Gly Xaa Pro Ser Gly Ser Pro Phe Pro Ser Gln Gln 
                965                 970                 975     


Xaa Xaa Met Tyr Gln Gln Gln Gln Gln Asn Tyr Lys Arg Pro Met Asp 
            980                 985                 990         


Gly Xaa Tyr Gly Pro Pro Ala Lys  Arg His Glu Gly Glu  Met Tyr Ser 
        995                 1000                 1005             


Val Pro  Tyr Ser Xaa Gly Gln  Gly Gln Pro Gln Gln  Gln Gln Leu 
    1010                 1015                 1020             


Pro Pro  Ala Gln Pro Gln Pro  Ala Ser Gln Gln Gln  Ala Ala Gln 
    1025                 1030                 1035             


Pro Ser  Pro Gln Gln Asp Val  Tyr Asn Gln Tyr Gly  Asn Ala Tyr 
    1040                 1045                 1050             


Pro Ala  Xaa Ala Xaa Ala Ala  Xaa Glu Arg Arg Pro  Ala Gly Gly 
    1055                 1060                 1065             


Pro Gln  Asn Gln Phe Pro Phe  Gln Phe Gly Arg Asp  Arg Val Ser 
    1070                 1075                 1080             


Ala Pro  Pro Gly Xaa Asn Ala  Gln Gln Asn Met Pro  Pro Gln Met 
    1085                 1090                 1095             


Met Gly  Gly Pro Ile Gln Ala  Ser Ala Glu Val Ala  Gln Gln Gly 
    1100                 1105                 1110             


Xaa Met  Trp Gln Gly Arg Asn  Asp Met Xaa Tyr Asn  Tyr Ala Asn 
    1115                 1120                 1125             


Arg Gln  Ser Xaa Gly Ser Ala  Pro Gln Gly Pro Ala  Tyr His Gly 
    1130                 1135                 1140             


Val Asn  Arg Xaa Asp Glu Met  Leu His Xaa Asp Gln  Arg Ala Asn 
    1145                 1150                 1155             


His Glu  Gly Ser Trp Pro Ser  His Gly Xaa Arg Gln  Pro Pro Tyr 
    1160                 1165                 1170             


Gly Pro  Ser Ala Pro Val Pro  Pro Met Xaa Arg Pro  Pro Pro Ser 
    1175                 1180                 1185             


Asn Tyr  Gln Pro Pro Pro Ser  Met Gln Asn His Ile  Pro Gln Val 
    1190                 1195                 1200             


Ser Ser  Pro Ala Pro Leu Pro  Arg Pro Met Glu Asn  Arg Xaa Ser 
    1205                 1210                 1215             


Pro Ser  Lys Ser Pro Phe Leu  His Ser Gly Met Lys  Met Gln Lys 
    1220                 1225                 1230             


Ala Gly  Pro Pro Val Pro Ala  Ser His Ile Ala Pro  Ala Pro Val 
    1235                 1240                 1245             


Gln Pro  Pro Met Ile Arg Arg  Asp Ile Xaa Phe Pro  Pro Gly Ser 
    1250                 1255                 1260             


Val Glu  Ala Xaa Gln Pro Val  Leu Lys Gln Arg Arg  Arg Leu Xaa 
    1265                 1270                 1275             


Met Lys  Asp Ile Gly Xaa Pro  Glu Ala Trp Arg Val  Met Met Ser 
    1280                 1285                 1290             


Leu Lys  Ser Gly Leu Leu Ala  Glu Ser Xaa Trp Ala  Leu Asp Xaa 
    1295                 1300                 1305             


Ile Asn  Ile Leu Leu Tyr Asp  Asp Asn Ser Ile Met  Xaa Phe Asn 
    1310                 1315                 1320             


Leu Ser  Gln Leu Pro Gly Leu  Leu Glu Leu Leu Val  Glu Tyr Phe 
    1325                 1330                 1335             


Arg Arg  Cys Leu Ile Glu Ile  Phe Gly Ile Leu Lys  Glu Tyr Glu 
    1340                 1345                 1350             


Val Gly  Asp Pro Gly Gln Arg  Xaa Leu Leu Asp Pro  Gly Arg Phe 
    1355                 1360                 1365             


Ser Lys  Val Ser Ser Pro Ala  Pro Met Glu Gly Gly  Glu Glu Glu 
    1370                 1375                 1380             


Glu Glu  Leu Leu Gly Pro Lys  Leu Glu Glu Glu Glu  Glu Glu Glu 
    1385                 1390                 1395             


Val Val  Glu Asn Asp Glu Glu  Ile Ala Phe Ser Gly  Lys Asp Lys 
    1400                 1405                 1410             


Pro Ala  Ser Glu Asn Ser Glu  Glu Lys Leu Ile Ser  Lys Phe Asp 
    1415                 1420                 1425             


Lys Leu  Pro Val Lys Ile Val  Gln Lys Asn Asp Pro  Phe Val Val 
    1430                 1435                 1440             


Asp Cys  Ser Asp Lys Leu Gly  Arg Val Gln Glu Phe  Asp Ser Gly 
    1445                 1450                 1455             


Leu Leu  His Trp Arg Ile Gly  Gly Gly Asp Xaa Xaa  Glu His Ile 
    1460                 1465                 1470             


Gln Xaa  His Phe Glu Ser Lys  Xaa Glu Leu Leu Pro  Ser Arg Pro 
    1475                 1480                 1485             


His Ala  Pro Cys Pro Pro Ala  Pro Arg Lys His Val  Xaa Xaa Ala 
    1490                 1495                 1500             


Glu Gly  Xaa Pro Gly Xaa Xaa  Asp Gln Glu Gly Pro  Pro Pro Asp 
    1505                 1510                 1515             


Gly Pro  Pro Glu Lys Arg Ile  Xaa Ala Xaa Met Asp  Asp Met Leu 
    1520                 1525                 1530             


Ser Xaa  Arg Ser Ser Xaa Leu  Xaa Glu Asp Gly Ala  Lys Ser Ser 
    1535                 1540                 1545             


Glu Ala  Ile Lys Glu Ser Ser  Lys Phe Pro Phe Gly  Ile Ser Pro 
    1550                 1555                 1560             


Ala Gln  Ser His Arg Asn Ile  Lys Ile Leu Glu Asp  Glu Pro His 
    1565                 1570                 1575             


Ser Lys  Asp Glu Xaa Pro Leu  Cys Xaa Leu Leu Asp  Trp Gln Asp 
    1580                 1585                 1590             


Ser Leu  Ala Lys Arg Cys Val  Cys Val Ser Asn Xaa  Ile Arg Ser 
    1595                 1600                 1605             


Leu Ser  Phe Val Pro Gly Asn  Asp Phe Glu Met Ser  Lys His Pro 
    1610                 1615                 1620             


Gly Leu  Leu Leu Ile Leu Gly  Lys Leu Ile Leu Leu  His His Lys 
    1625                 1630                 1635             


His Pro  Glu Arg Lys Gln Ala  Pro Leu Xaa Tyr Glu  Lys Glu Glu 
    1640                 1645                 1650             


Glu Gln  Asp Gln Gly Val Ser  Cys Asn Lys Val Glu  Trp Trp Trp 
    1655                 1660                 1665             


Asp Cys  Leu Glu Met Leu Arg  Glu Asn Xaa Leu Val  Xaa Leu Ala 
    1670                 1675                 1680             


Asn Ile  Ser Gly Gln Leu Asp  Leu Ser Pro Tyr Pro  Glu Ser Ile 
    1685                 1690                 1695             


Cys Leu  Pro Val Leu Asp Gly  Leu Leu His Trp Ala  Val Cys Pro 
    1700                 1705                 1710             


Ser Ala  Glu Ala Gln Asp Pro  Phe Ser Xaa Leu Gly  Pro Asn Ala 
    1715                 1720                 1725             


Val Leu  Ser Pro Gln Arg Leu  Val Leu Glu Xaa Leu  Ser Lys Leu 
    1730                 1735                 1740             


Ser Ile  Gln Asp Asn Asn Val  Asp Leu Ile Leu Ala  Xaa Pro Pro 
    1745                 1750                 1755             


Phe Ser  Arg Leu Glu Lys Leu  Tyr Ser Xaa Met Val  Arg Phe Leu 
    1760                 1765                 1770             


Ser Asp  Arg Lys Asn Pro Val  Cys Arg Glu Met Ala  Val Val Leu 
    1775                 1780                 1785             


Leu Ala  Asn Leu Ala Gln Gly  Asp Ser Leu Ala Ala  Arg Ala Ile 
    1790                 1795                 1800             


Ala Val  Gln Lys Gly Ser Ile  Gly Asn Leu Leu Gly  Phe Leu Glu 
    1805                 1810                 1815             


Asp Ser  Leu Ala Ala Xaa Gln  Phe Gln Gln Ser Gln  Ala Ser Leu 
    1820                 1825                 1830             


Leu His  Met Gln Asn Pro Pro  Phe Glu Pro Xaa Ser  Val Asp Met 
    1835                 1840                 1845             


Met Arg  Arg Ala Ala Arg Ala  Leu Leu Ala Leu Ala  Lys Val Asp 
    1850                 1855                 1860             


Glu Asn  His Ser Glu Phe Xaa  Leu Tyr Glu Ser Arg  Leu Leu Asp 
    1865                 1870                 1875             


Ile Ser  Val Ser Pro Leu Met  Asn Ser Leu Val Ser  Gln Val Ile 
    1880                 1885                 1890             


Cys Asp  Val Leu Phe Leu Ile  Gly Gln Ser 
    1895                 1900             


<210> 3100
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<400> 3100
Xaa Gly Xaa Arg Gln Pro Pro Tyr Gly Pro Ser Ala Pro Val Pro Pro 
1               5                   10                  15      


Met Xaa Arg Pro Pro Pro Ser Asn Tyr Gln Pro Pro Pro Ser Met Gln 
            20                  25                  30          


Asn His Ile Pro Gln Val Ser Ser Pro Ala Pro Leu Pro Arg Pro Met 
        35                  40                  45              


Glu Asn Arg Xaa Ser Pro Ser Lys Ser Pro Phe Leu His Ser Gly Met 
    50                  55                  60                  


Lys Met Gln Lys Ala Gly Pro Pro Val Pro Ala Ser His Ile Ala Pro 
65                  70                  75                  80  


Ala Pro Val Gln Pro Pro Met Ile Arg Arg Asp Ile Xaa Phe Pro Pro 
                85                  90                  95      


Gly Ser Val Glu Ala Xaa Gln Pro Val Leu Lys Gln Arg Arg Arg Leu 
            100                 105                 110         


Xaa Met Lys Asp Ile Gly Xaa Pro Glu Ala Trp Arg Val Met Met Ser 
        115                 120                 125             


Leu Lys Ser Gly Leu Leu Ala Glu Ser Xaa Trp Ala Leu Asp Xaa Ile 
    130                 135                 140                 


Asn Ile Leu Leu Tyr Asp Asp Asn Ser Ile Met Xaa Phe Asn Leu Ser 
145                 150                 155                 160 


Gln Ile Ser Ser Met Pro Val Leu Cys Phe Leu Cys Leu Trp Ala Arg 
                165                 170                 175     


Ala Gln Asp Phe Asp Ser Asn Asn Asn Leu Phe Xaa 
            180                 185             


<210> 3101
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(130)
<223> Selenocysteine

<400> 3101
Xaa Pro Tyr Gly Ser Met Arg Lys Ala Pro Gly Ser Asp Pro Phe Met 
1               5                   10                  15      


Ser Ser Gly Gln Gly Pro Asn Gly Gly Met Gly Asp Pro Tyr Ser Arg 
            20                  25                  30          


Ala Ala Gly Pro Gly Leu Gly Asn Val Ala Met Gly Pro Arg Gln His 
        35                  40                  45              


Tyr Pro Tyr Gly Gly Pro Tyr Asp Arg Val Arg Xaa Glu Pro Gly Ile 
    50                  55                  60                  


Gly Pro Glu Gly Asn Met Ser Xaa Gly Ala Pro Gln Pro Asn Leu Met 
65                  70                  75                  80  


Pro Ser Asn Pro Asp Ser Gly Met Tyr Ser Pro Ser Arg Tyr Pro Pro 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Gln Arg His Asp Ser Tyr Gly Asn Gln 
            100                 105                 110         


Phe Ser Xaa Gln Gly Xaa Pro Ser Gly Ser Pro Phe Pro Ser Gln Gln 
        115                 120                 125             


Xaa Xaa Met Tyr Gln Gln Gln Gln Gln Glu Pro Arg Arg His Gly Gly 
    130                 135                 140                 


<210> 3102
<211> 97
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<400> 3102
Ala Ala Ala Gln Gln Arg Ser His Pro Ala Met Ser Pro Gly Xaa Pro 
1               5                   10                  15      


Gly Pro Xaa Met Gly Arg Ser Gln Gly Ser Pro Met Asp Pro Met Val 
            20                  25                  30          


Met Lys Arg Pro Gln Leu Tyr Gly Met Gly Ser Asn Pro His Ser Gln 
        35                  40                  45              


Pro Gln Gln Ser Ser Pro Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly 
    50                  55                  60                  


Pro Gln Arg Tyr Pro Ile Gly Ile Gln Gly Arg Xaa Pro Gly Ala Met 
65                  70                  75                  80  


Ala Gly Met Gln Tyr Pro Gln Gln Gln Asp Leu Leu Ser Ser Phe Gln 
                85                  90                  95      


Phe 
    


<210> 3103
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 3103
Ala Ala Ala Gln Gln Arg Ser His Pro Ala Met Ser Pro Gly Xaa Pro 
1               5                   10                  15      


Gly Pro Xaa Met Gly Arg Ser Gln Gly Ser Pro Met Asp Pro Met Val 
            20                  25                  30          


Met Lys Arg Pro Gln Leu Tyr Gly Met Gly Ser Asn Pro His Ser Gln 
        35                  40                  45              


Pro Gln Gln Ser Ser Pro Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly 
    50                  55                  60                  


Pro Gln Arg Tyr Pro Ile Gly Ile Gln Gly Arg Xaa Pro Gly Ala Met 
65                  70                  75                  80  


Ala Gly Met Gln Tyr Pro Gln Gln Gln Met Pro Pro Gln Tyr Gly Gln 
                85                  90                  95      


Gln Gly Val Ser Gly Tyr Cys Gln Gln Gly Gln Gln Pro Tyr Tyr Ser 
            100                 105                 110         


Gln Gln Pro Gln Pro Pro His Leu Pro Pro Gln Ala Gln Tyr Leu Pro 
        115                 120                 125             


Ser Gln Ser Gln Gln Arg Tyr Gln Pro Gln Gln Asp Met Ser Gln Glu 
    130                 135                 140                 


Gly Tyr Gly Xaa Arg Ser Gln Pro Pro Leu Ala Pro Gly Lys Pro Asn 
145                 150                 155                 160 


His Glu Asp Leu Asn Leu Ile Gln Gln Glu Arg Pro Ser Ser Leu Pro 
                165                 170                 175     


Val Arg His Tyr Cys Ala Asp Leu Glu Met 
            180                 185     


<210> 3104
<211> 1349
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (873)..(873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (983)..(983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1131)..(1131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1176)..(1176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1221)..(1221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<400> 3104
Ala Ala Ala Val Met Gln Ala Ala Ala Asn Ser Ala Gln Ser Arg Gln 
1               5                   10                  15      


Gly Ser Phe Pro Gly Met Asn Gln Ser Gly Leu Met Ala Ser Ser Ser 
            20                  25                  30          


Pro Tyr Ser Gln Pro Met Asn Asn Ser Ser Ser Leu Met Asn Xaa Gln 
        35                  40                  45              


Ala Pro Pro Tyr Ser Met Ala Pro Ala Met Val Asn Ser Ser Ala Ala 
    50                  55                  60                  


Ser Val Gly Leu Ala Asp Met Met Ser Pro Gly Glu Ser Lys Leu Pro 
65                  70                  75                  80  


Leu Pro Leu Lys Ala Asp Gly Lys Glu Glu Gly Xaa Pro Gln Pro Glu 
                85                  90                  95      


Ser Lys Ser Lys Asp Ser Tyr Ser Ser Gln Gly Ile Ser Gln Pro Pro 
            100                 105                 110         


Xaa Pro Gly Asn Leu Pro Val Pro Ser Pro Met Ser Pro Ser Ser Ala 
        115                 120                 125             


Ser Ile Ser Ser Phe His Gly Asp Glu Ser Asp Ser Ile Ser Ser Pro 
    130                 135                 140                 


Gly Trp Pro Lys Xaa Pro Ser Ser Pro Lys Ser Ser Ser Ser Xaa Xaa 
145                 150                 155                 160 


Xaa Gly Glu Lys Ile Xaa Lys Val Tyr Glu Leu Gly Asn Glu Pro Glu 
                165                 170                 175     


Arg Lys Leu Trp Val Asp Arg Tyr Leu Xaa Phe Met Glu Glu Arg Gly 
            180                 185                 190         


Ser Pro Val Ser Ser Leu Pro Ala Val Gly Lys Lys Pro Leu Asp Leu 
        195                 200                 205             


Phe Arg Leu Tyr Val Cys Val Lys Glu Ile Gly Gly Leu Ala Gln Val 
    210                 215                 220                 


Asn Lys Asn Lys Lys Trp Arg Glu Leu Ala Xaa Asn Leu Asn Val Gly 
225                 230                 235                 240 


Xaa Ser Ser Ser Ala Ala Ser Ser Leu Lys Lys Gln Tyr Ile Gln Tyr 
                245                 250                 255     


Leu Phe Ala Phe Glu Cys Lys Ile Glu Arg Gly Glu Glu Pro Pro Pro 
            260                 265                 270         


Glu Val Phe Ser Xaa Gly Asp Xaa Lys Lys Gln Pro Lys Leu Gln Pro 
        275                 280                 285             


Pro Ser Pro Ala Asn Ser Gly Ser Leu Gln Gly Pro Gln Xaa Pro Gln 
    290                 295                 300                 


Ser Xaa Gly Ser Asn Ser Met Ala Glu Val Pro Gly Asp Leu Lys Pro 
305                 310                 315                 320 


Pro Xaa Pro Ala Ser Xaa Pro His Gly Gln Met Xaa Pro Met Gln Gly 
                325                 330                 335     


Gly Ser Ser Xaa Ile Ser Val His Asp Pro Phe Ser Asp Val Ser Asp 
            340                 345                 350         


Ser Ser Phe Pro Lys Arg Asn Ser Met Xaa Pro Asn Ala Pro Tyr Gln 
        355                 360                 365             


Gln Gly Met Ser Met Pro Asp Val Met Gly Arg Met Pro Tyr Glu Pro 
    370                 375                 380                 


Asn Lys Asp Pro Phe Gly Gly Met Arg Lys Val Pro Gly Ser Ser Glu 
385                 390                 395                 400 


Pro Phe Met Xaa Gln Gly Gln Met Pro Asn Ser Ser Met Gln Asp Met 
                405                 410                 415     


Tyr Asn Gln Ser Pro Ser Gly Ala Met Ser Asn Leu Gly Met Gly Gln 
            420                 425                 430         


Arg Gln Gln Phe Pro Tyr Gly Ala Ser Tyr Asp Arg Arg His Glu Pro 
        435                 440                 445             


Tyr Gly Gln Gln Tyr Pro Gly Gln Gly Pro Pro Ser Gly Gln Pro Pro 
    450                 455                 460                 


Tyr Gly Gly His Gln Pro Gly Leu Tyr Pro Gln Gln Pro Asn Tyr Lys 
465                 470                 475                 480 


Arg His Met Asp Gly Met Tyr Gly Pro Pro Ala Lys Arg His Glu Gly 
                485                 490                 495     


Asp Met Tyr Asn Met Gln Tyr Ser Ser Gln Gln Gln Glu Met Tyr Asn 
            500                 505                 510         


Gln Tyr Gly Gly Ser Tyr Ser Gly Pro Asp Arg Arg Pro Ile Gln Gly 
        515                 520                 525             


Gln Tyr Pro Tyr Pro Tyr Ser Arg Glu Arg Met Gln Gly Pro Gly Gln 
    530                 535                 540                 


Ile Gln Xaa His Gly Ile Pro Pro Gln Met Met Gly Gly Pro Leu Gln 
545                 550                 555                 560 


Ser Ser Ser Ser Glu Gly Pro Gln Gln Asn Met Trp Ala Ala Arg Asn 
                565                 570                 575     


Asp Met Pro Tyr Pro Tyr Gln Asn Arg Gln Gly Pro Gly Gly Pro Xaa 
            580                 585                 590         


Gln Ala Pro Pro Tyr Pro Gly Met Asn Arg Xaa Asp Asp Met Met Val 
        595                 600                 605             


Pro Asp Gln Arg Ile Asn His Glu Ser Gln Trp Pro Ser His Val Ser 
    610                 615                 620                 


Gln Arg Gln Pro Tyr Met Ser Ser Ser Ala Ser Met Gln Pro Ile Xaa 
625                 630                 635                 640 


Arg Pro Pro Gln Pro Ser Tyr Gln Xaa Pro Pro Ser Leu Pro Asn His 
                645                 650                 655     


Ile Ser Arg Ala Pro Ser Pro Ala Ser Phe Gln Arg Ser Leu Glu Asn 
            660                 665                 670         


Arg Met Ser Pro Ser Lys Ser Pro Phe Leu Pro Ser Met Lys Met Gln 
        675                 680                 685             


Lys Val Met Pro Xaa Val Pro Xaa Ser Gln Val Xaa Gly Pro Pro Pro 
    690                 695                 700                 


Gln Pro Pro Pro Ile Arg Arg Glu Ile Xaa Phe Pro Pro Gly Ser Val 
705                 710                 715                 720 


Glu Ala Ser Gln Pro Val Leu Lys Gln Arg Arg Lys Ile Xaa Ser Lys 
                725                 730                 735     


Asp Ile Val Xaa Pro Glu Ala Trp Arg Val Met Met Ser Leu Lys Ser 
            740                 745                 750         


Gly Leu Leu Ala Glu Ser Xaa Trp Ala Leu Asp Xaa Ile Asn Ile Leu 
        755                 760                 765             


Leu Tyr Asp Asp Ser Xaa Val Ala Xaa Phe Asn Leu Ser Gln Leu Ser 
    770                 775                 780                 


Gly Phe Leu Glu Leu Leu Val Glu Tyr Phe Arg Lys Cys Leu Ile Asp 
785                 790                 795                 800 


Ile Phe Gly Ile Leu Met Glu Tyr Glu Val Gly Asp Pro Ser Gln Lys 
                805                 810                 815     


Ala Leu Asp His Asn Ala Ala Arg Lys Asp Asp Ser Gln Ser Leu Ala 
            820                 825                 830         


Asp Asp Ser Gly Lys Glu Glu Glu Asp Ala Glu Cys Ile Asp Asp Asp 
        835                 840                 845             


Glu Glu Asp Glu Glu Asp Glu Glu Glu Asp Ser Glu Lys Xaa Glu Ser 
    850                 855                 860                 


Asp Glu Lys Ser Ser Ile Ala Leu Xaa Ala Pro Asp Ala Ala Ala Asp 
865                 870                 875                 880 


Pro Lys Glu Lys Pro Lys Gln Ala Ser Lys Phe Asp Lys Leu Pro Ile 
                885                 890                 895     


Lys Ile Val Lys Lys Asn Asn Leu Phe Val Val Asp Arg Ser Asp Lys 
            900                 905                 910         


Leu Gly Arg Val Gln Glu Phe Asn Ser Gly Leu Leu His Trp Gln Leu 
        915                 920                 925             


Gly Gly Gly Asp Xaa Xaa Glu His Ile Gln Xaa His Phe Glu Ser Lys 
    930                 935                 940                 


Met Glu Ile Pro Pro Arg Arg Arg Pro Pro Pro Pro Leu Ser Ser Ala 
945                 950                 955                 960 


Gly Arg Lys Lys Glu Gln Glu Gly Lys Gly Asp Ser Glu Glu Gln Gln 
                965                 970                 975     


Glu Lys Ser Ile Ile Ala Xaa Ile Asp Asp Val Leu Ser Ala Arg Pro 
            980                 985                 990         


Gly Ala Leu Pro Glu Asp Ala Asn  Pro Gly Pro Gln Xaa  Glu Ser Ser 
        995                 1000                 1005             


Lys Phe  Pro Phe Gly Ile Gln  Gln Ala Lys Ser His  Arg Asn Ile 
    1010                 1015                 1020             


Lys Leu  Leu Glu Asp Glu Pro  Arg Ser Arg Asp Glu  Xaa Pro Leu 
    1025                 1030                 1035             


Cys Xaa  Ile Ala His Trp Gln  Asp Ser Leu Ala Lys  Arg Cys Ile 
    1040                 1045                 1050             


Cys Val  Ser Asn Ile Val Arg  Ser Leu Ser Phe Val  Pro Gly Asn 
    1055                 1060                 1065             


Asp Ala  Glu Met Ser Lys His  Pro Gly Leu Val Leu  Ile Leu Gly 
    1070                 1075                 1080             


Lys Leu  Ile Leu Leu His His  Glu His Pro Glu Arg  Lys Arg Ala 
    1085                 1090                 1095             


Pro Gln  Xaa Tyr Glu Lys Glu  Glu Asp Glu Asp Lys  Gly Val Ala 
    1100                 1105                 1110             


Cys Ser  Lys Asp Glu Trp Trp  Trp Asp Cys Leu Glu  Val Leu Arg 
    1115                 1120                 1125             


Asp Asn  Xaa Leu Val Xaa Leu  Ala Asn Ile Ser Gly  Gln Leu Asp 
    1130                 1135                 1140             


Leu Ser  Ala Tyr Xaa Glu Ser  Ile Cys Leu Pro Ile  Leu Asp Gly 
    1145                 1150                 1155             


Leu Leu  His Trp Met Val Cys  Pro Ser Ala Glu Ala  Gln Asp Pro 
    1160                 1165                 1170             


Phe Pro  Xaa Val Gly Pro Asn  Ser Val Leu Ser Pro  Gln Arg Leu 
    1175                 1180                 1185             


Val Leu  Glu Xaa Leu Cys Lys  Leu Ser Ile Gln Asp  Asn Asn Val 
    1190                 1195                 1200             


Asp Leu  Ile Leu Ala Xaa Pro  Pro Phe Ser Arg Gln  Glu Lys Phe 
    1205                 1210                 1215             


Tyr Ala  Xaa Leu Val Arg Tyr  Val Gly Asp Arg Lys  Asn Pro Val 
    1220                 1225                 1230             


Cys Arg  Glu Met Ser Met Ala  Leu Leu Ser Asn Leu  Ala Gln Gly 
    1235                 1240                 1245             


Asp Ala  Leu Ala Ala Arg Ala  Ile Ala Val Gln Lys  Gly Ser Ile 
    1250                 1255                 1260             


Gly Asn  Leu Ile Ser Phe Leu  Glu Asp Gly Val Xaa  Met Ala Gln 
    1265                 1270                 1275             


Tyr Gln  Gln Ser Gln His Asn  Leu Met His Met Gln  Pro Pro Pro 
    1280                 1285                 1290             


Leu Glu  Pro Pro Ser Val Asp  Met Met Cys Arg Ala  Ala Lys Ala 
    1295                 1300                 1305             


Leu Leu  Ala Met Ala Arg Val  Asp Glu Asn Arg Ser  Glu Phe Leu 
    1310                 1315                 1320             


Leu His  Glu Gly Arg Leu Leu  Asp Ile Ser Ile Ser  Ala Val Leu 
    1325                 1330                 1335             


Asn Ser  Leu Val Ala Ser Val  Ile Cys Asp Val 
    1340                 1345                 


<210> 3105
<211> 273
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<400> 3105
Ala Ala Val Met Gln Ala Ala Ala Asn Ser Ala Gln Ser Arg Gln Gly 
1               5                   10                  15      


Ser Phe Pro Gly Met Asn Gln Ser Gly Leu Met Ala Ser Ser Ser Pro 
            20                  25                  30          


Tyr Ser Gln Pro Met Asn Asn Ser Ser Ser Leu Met Asn Xaa Gln Ala 
        35                  40                  45              


Pro Pro Tyr Ser Met Ala Pro Ala Met Val Asn Ser Ser Ala Ala Ser 
    50                  55                  60                  


Val Gly Leu Ala Asp Met Met Ser Pro Gly Glu Ser Lys Leu Pro Leu 
65                  70                  75                  80  


Pro Leu Lys Ala Asp Gly Lys Glu Glu Gly Xaa Pro Gln Pro Glu Ser 
                85                  90                  95      


Lys Ser Lys Lys Ser Ser Ser Ser Xaa Xaa Xaa Gly Glu Lys Ile Xaa 
            100                 105                 110         


Lys Val Tyr Glu Leu Gly Asn Glu Pro Glu Arg Lys Leu Trp Val Asp 
        115                 120                 125             


Arg Tyr Leu Xaa Phe Met Glu Glu Arg Gly Ser Pro Val Ser Ser Leu 
    130                 135                 140                 


Pro Ala Val Gly Lys Lys Pro Leu Asp Leu Phe Arg Leu Tyr Val Cys 
145                 150                 155                 160 


Val Lys Glu Ile Gly Gly Leu Ala Gln Val Asn Lys Asn Lys Lys Trp 
                165                 170                 175     


Arg Glu Leu Ala Xaa Asn Leu Asn Val Gly Xaa Ser Ser Ser Ala Ala 
            180                 185                 190         


Ser Ser Leu Lys Lys Gln Tyr Ile Gln Tyr Leu Phe Ala Phe Glu Cys 
        195                 200                 205             


Lys Ile Glu Arg Gly Glu Glu Pro Pro Pro Glu Val Phe Ser Xaa Gly 
    210                 215                 220                 


Asp Xaa Lys Lys Gln Pro Lys Leu Gln Pro Pro Ser Pro Gly Lys Trp 
225                 230                 235                 240 


Arg Arg Cys Ser His Trp Pro Arg Lys Ala Gln Ala Pro Gly Leu Gly 
                245                 250                 255     


Gly Ser Gly Lys Val Val Ser Gln Ser Gly Gln Gln Gly Xaa Trp Asp 
            260                 265                 270         


Phe 
    


<210> 3106
<211> 2236
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1120)..(1120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1211)..(1211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1520)..(1520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1529)..(1529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1576)..(1576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1580)..(1580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1614)..(1614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1620)..(1620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1639)..(1639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1644)..(1644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1654)..(1654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1742)..(1742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1753)..(1753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1813)..(1814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1819)..(1819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1863)..(1863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1885)..(1885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1916)..(1916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1920)..(1920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1981)..(1981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2011)..(2011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2014)..(2014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2028)..(2028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2056)..(2056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2072)..(2072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2089)..(2089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2101)..(2101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2155)..(2155)
<223> Selenocysteine

<400> 3106
Met Ala His Asn Ala Gly Ala Ala Ala Ala Ala Gly Xaa His Ser Ala 
1               5                   10                  15      


Lys Ser Gly Gly Ser Glu Ala Ala Leu Lys Glu Gly Gly Ser Ala Ala 
            20                  25                  30          


Ala Leu Ser Ser Ser Ser Ser Ser Ser Ala Ala Ala Ala Ala Ala Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Gly Pro Gly Ser Ala Met Glu Xaa Gly Leu Leu 
    50                  55                  60                  


Pro Asn His Lys Leu Lys Xaa Val Gly Glu Ala Pro Ala Ala Pro Pro 
65                  70                  75                  80  


His Gln Gln His His His His His His Ala His His His His His His 
                85                  90                  95      


Ala His His Leu His His His His Ala Leu Gln Gln Gln Leu Asn Gln 
            100                 105                 110         


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        115                 120                 125             


Gln Gln Gln His Pro Ile Ser Asn Asn Asn Ser Leu Gly Gly Ala Gly 
    130                 135                 140                 


Gly Gly Ala Pro Gln Pro Gly Pro Asp Met Glu Gln Pro Gln His Gly 
145                 150                 155                 160 


Gly Ala Lys Asp Ser Ala Ala Gly Gly Gln Ala Asp Pro Pro Gly Pro 
                165                 170                 175     


Pro Leu Leu Ser Lys Pro Gly Asp Glu Asp Asp Ala Pro Pro Lys Met 
            180                 185                 190         


Gly Glu Pro Ala Gly Gly Arg Tyr Glu His Pro Gly Leu Gly Ala Leu 
        195                 200                 205             


Gly Xaa Gln Gln Pro Pro Val Ala Val Pro Gly Gly Gly Gly Gly Pro 
    210                 215                 220                 


Ala Ala Val Pro Glu Phe Asn Asn Tyr Tyr Gly Ser Ala Ala Pro Ala 
225                 230                 235                 240 


Ser Gly Gly Pro Gly Gly Arg Ala Gly Pro Cys Phe Asp Gln His Gly 
                245                 250                 255     


Gly Gln Gln Ser Pro Gly Met Gly Met Met His Ser Ala Ser Ala Ala 
            260                 265                 270         


Ala Ala Gly Ala Pro Gly Ser Met Asp Pro Leu Gln Asn Ser His Glu 
        275                 280                 285             


Gly Tyr Pro Asn Ser Gln Cys Asn His Tyr Pro Gly Tyr Ser Arg Pro 
    290                 295                 300                 


Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Ala Gly Gly Ala Gly Ala 
                325                 330                 335     


Gly Ala Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly 
            340                 345                 350         


Gly Gly Gly Gly Gly Tyr Gly Gly Ser Ser Ala Gly Tyr Gly Val Leu 
        355                 360                 365             


Ser Ser Pro Arg Gln Gln Gly Gly Gly Met Met Met Gly Pro Gly Gly 
    370                 375                 380                 


Gly Gly Ala Ala Ser Leu Ser Lys Ala Ala Ala Gly Ser Ala Ala Gly 
385                 390                 395                 400 


Gly Phe Gln Arg Phe Ala Gly Gln Asn Gln His Pro Ser Gly Ala Xaa 
                405                 410                 415     


Pro Xaa Leu Asn Gln Leu Leu Xaa Ser Pro Ser Pro Met Met Arg Ser 
            420                 425                 430         


Tyr Gly Gly Ser Tyr Pro Glu Tyr Ser Ser Pro Ser Ala Pro Pro Pro 
        435                 440                 445             


Pro Pro Ser Gln Pro Gln Ser Gln Ala Ala Ala Ala Gly Ala Ala Ala 
    450                 455                 460                 


Gly Gly Gln Gln Ala Ala Ala Gly Met Gly Leu Gly Lys Asp Met Gly 
465                 470                 475                 480 


Ala Gln Tyr Ala Ala Ala Ser Pro Ala Trp Ala Ala Ala Gln Gln Arg 
                485                 490                 495     


Ser His Pro Ala Met Ser Pro Gly Xaa Pro Gly Pro Xaa Met Gly Arg 
            500                 505                 510         


Ser Gln Gly Ser Pro Met Asp Pro Met Val Met Lys Arg Pro Gln Leu 
        515                 520                 525             


Tyr Gly Met Gly Ser Asn Pro His Ser Gln Pro Gln Gln Ser Ser Pro 
    530                 535                 540                 


Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly Pro Gln Arg Tyr Pro Ile 
545                 550                 555                 560 


Gly Ile Gln Gly Arg Xaa Pro Gly Ala Met Ala Gly Met Gln Tyr Pro 
                565                 570                 575     


Gln Gln Gln Met Pro Pro Gln Tyr Gly Gln Gln Gly Val Ser Gly Tyr 
            580                 585                 590         


Cys Gln Gln Gly Gln Gln Pro Tyr Tyr Ser Gln Gln Pro Gln Pro Pro 
        595                 600                 605             


His Leu Pro Pro Gln Ala Gln Tyr Leu Pro Ser Gln Ser Gln Gln Arg 
    610                 615                 620                 


Tyr Gln Pro Gln Gln Asp Met Ser Gln Glu Gly Tyr Gly Xaa Arg Ser 
625                 630                 635                 640 


Gln Pro Pro Leu Ala Pro Gly Lys Pro Asn His Glu Asp Leu Asn Leu 
                645                 650                 655     


Ile Gln Gln Glu Arg Pro Ser Ser Leu Pro Asp Leu Ser Gly Ser Ile 
            660                 665                 670         


Asp Asp Leu Pro Xaa Gly Xaa Glu Ala Xaa Leu Ser Ser Ala Val Ser 
        675                 680                 685             


Ala Ser Gly Ser Xaa Ser Ser Gln Gly Asp Gln Ser Asn Pro Ala Gln 
    690                 695                 700                 


Ser Pro Phe Ser Pro His Ala Ser Pro His Leu Ser Ser Ile Pro Gly 
705                 710                 715                 720 


Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Val Gly Ser Asn Gln Ser 
                725                 730                 735     


Arg Ser Gly Pro Ile Ser Pro Ala Ser Ile Pro Gly Ser Gln Met Pro 
            740                 745                 750         


Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser Ser Ser His Pro Ala Leu 
        755                 760                 765             


Ser Gln Ser Pro Met Pro Gln Glu Arg Gly Phe Met Ala Gly Xaa Gln 
    770                 775                 780                 


Arg Asn Pro Gln Met Ala Gln Tyr Gly Pro Gln Gln Xaa Gly Pro Ser 
785                 790                 795                 800 


Met Ser Pro His Pro Ser Pro Gly Gly Gln Met His Ala Gly Ile Ser 
                805                 810                 815     


Ser Phe Gln Gln Ser Asn Ser Ser Gly Xaa Tyr Gly Pro Gln Met Ser 
            820                 825                 830         


Gln Tyr Gly Pro Gln Gly Asn Tyr Ser Arg Pro Pro Ala Tyr Ser Gly 
        835                 840                 845             


Val Pro Ser Ala Ser Tyr Ser Gly Pro Gly Pro Gly Met Gly Ile Ser 
    850                 855                 860                 


Ala Asn Asn Gln Met His Gly Gln Gly Pro Ser Gln Pro Cys Gly Ala 
865                 870                 875                 880 


Val Pro Leu Gly Arg Met Pro Ser Ala Gly Met Gln Asn Arg Pro Phe 
                885                 890                 895     


Pro Gly Asn Met Ser Ser Met Xaa Pro Ser Ser Pro Gly Met Ser Gln 
            900                 905                 910         


Gln Gly Gly Pro Gly Met Gly Pro Pro Met Pro Xaa Val Asn Arg Lys 
        915                 920                 925             


Ala Gln Glu Ala Ala Ala Ala Val Met Gln Ala Ala Ala Asn Ser Ala 
    930                 935                 940                 


Gln Ser Arg Gln Gly Ser Phe Pro Gly Met Asn Gln Ser Gly Leu Met 
945                 950                 955                 960 


Ala Ser Ser Ser Pro Tyr Ser Gln Pro Met Asn Asn Ser Ser Ser Leu 
                965                 970                 975     


Met Asn Xaa Gln Ala Pro Pro Tyr Ser Met Ala Pro Ala Met Val Asn 
            980                 985                 990         


Ser Ser Ala Ala Ser Val Gly Leu  Ala Asp Met Met Ser  Pro Gly Glu 
        995                 1000                 1005             


Ser Lys  Leu Pro Leu Pro Leu  Lys Ala Asp Gly Lys  Glu Glu Gly 
    1010                 1015                 1020             


Xaa Pro  Gln Pro Glu Ser Lys  Ser Lys Lys Ser Ser  Ser Ser Xaa 
    1025                 1030                 1035             


Xaa Xaa  Gly Glu Lys Ile Xaa  Lys Val Tyr Glu Leu  Gly Asn Glu 
    1040                 1045                 1050             


Pro Glu  Arg Lys Leu Trp Val  Asp Arg Tyr Leu Xaa  Phe Met Glu 
    1055                 1060                 1065             


Glu Arg  Gly Ser Pro Val Ser  Ser Leu Pro Ala Val  Gly Lys Lys 
    1070                 1075                 1080             


Pro Leu  Asp Leu Phe Arg Leu  Tyr Val Cys Val Lys  Glu Ile Gly 
    1085                 1090                 1095             


Gly Leu  Ala Gln Val Asn Lys  Asn Lys Lys Trp Arg  Glu Leu Ala 
    1100                 1105                 1110             


Xaa Asn  Leu Asn Val Gly Xaa  Ser Ser Ser Ala Ala  Ser Ser Leu 
    1115                 1120                 1125             


Lys Lys  Gln Tyr Ile Gln Tyr  Leu Phe Ala Phe Glu  Cys Lys Ile 
    1130                 1135                 1140             


Glu Arg  Gly Glu Glu Pro Pro  Pro Glu Val Phe Ser  Xaa Gly Asp 
    1145                 1150                 1155             


Xaa Lys  Lys Gln Pro Lys Leu  Gln Pro Pro Ser Pro  Ala Asn Ser 
    1160                 1165                 1170             


Gly Ser  Leu Gln Gly Pro Gln  Xaa Pro Gln Ser Xaa  Gly Ser Asn 
    1175                 1180                 1185             


Ser Met  Ala Glu Val Pro Gly  Asp Leu Lys Pro Pro  Xaa Pro Ala 
    1190                 1195                 1200             


Ser Xaa  Pro His Gly Gln Met  Xaa Pro Met Gln Gly  Gly Arg Ser 
    1205                 1210                 1215             


Ser Xaa  Ile Ser Val His Asp  Pro Phe Ser Asp Val  Ser Asp Ser 
    1220                 1225                 1230             


Ser Phe  Pro Lys Arg Asn Ser  Met Xaa Pro Asn Ala  Pro Tyr Gln 
    1235                 1240                 1245             


Gln Gly  Met Ser Met Pro Asp  Val Met Gly Arg Met  Pro Tyr Glu 
    1250                 1255                 1260             


Pro Asn  Lys Asp Pro Phe Gly  Gly Met Arg Lys Val  Pro Gly Ser 
    1265                 1270                 1275             


Ser Glu  Pro Phe Met Xaa Gln  Gly Gln Met Pro Asn  Ser Ser Met 
    1280                 1285                 1290             


Gln Asp  Met Tyr Asn Gln Ser  Pro Ser Gly Ala Met  Ser Asn Leu 
    1295                 1300                 1305             


Gly Met  Gly Gln Arg Gln Gln  Phe Pro Tyr Gly Ala  Ser Tyr Asp 
    1310                 1315                 1320             


Arg Arg  His Glu Pro Tyr Gly  Gln Gln Tyr Pro Gly  Gln Gly Pro 
    1325                 1330                 1335             


Pro Ser  Gly Gln Pro Pro Tyr  Gly Gly His Gln Pro  Gly Leu Tyr 
    1340                 1345                 1350             


Pro Gln  Gln Pro Asn Tyr Lys  Arg His Met Asp Gly  Met Tyr Gly 
    1355                 1360                 1365             


Pro Pro  Ala Lys Arg His Glu  Gly Asp Met Tyr Asn  Met Gln Tyr 
    1370                 1375                 1380             


Ser Ser  Gln Gln Gln Glu Met  Tyr Asn Gln Tyr Gly  Gly Ser Tyr 
    1385                 1390                 1395             


Ser Gly  Pro Asp Arg Arg Pro  Ile Gln Gly Gln Tyr  Pro Tyr Pro 
    1400                 1405                 1410             


Tyr Ser  Arg Glu Arg Met Gln  Gly Pro Gly Gln Ile  Gln Xaa His 
    1415                 1420                 1425             


Gly Ile  Pro Pro Gln Met Met  Gly Gly Pro Leu Gln  Ser Ser Ser 
    1430                 1435                 1440             


Ser Glu  Gly Pro Gln Gln Asn  Met Trp Ala Ala Arg  Asn Asp Met 
    1445                 1450                 1455             


Pro Tyr  Pro Tyr Gln Asn Arg  Gln Gly Pro Gly Gly  Pro Xaa Gln 
    1460                 1465                 1470             


Ala Pro  Pro Tyr Pro Gly Met  Asn Arg Xaa Asp Asp  Met Met Val 
    1475                 1480                 1485             


Pro Asp  Gln Arg Ile Asn His  Glu Ser Gln Trp Pro  Ser His Val 
    1490                 1495                 1500             


Ser Gln  Arg Gln Pro Tyr Met  Ser Ser Ser Ala Ser  Met Gln Pro 
    1505                 1510                 1515             


Ile Xaa  Arg Pro Pro Gln Pro  Ser Tyr Gln Xaa Pro  Pro Ser Leu 
    1520                 1525                 1530             


Pro Asn  His Ile Ser Arg Ala  Pro Ser Pro Ala Ser  Phe Gln Arg 
    1535                 1540                 1545             


Ser Leu  Glu Asn Arg Met Ser  Pro Ser Lys Ser Pro  Phe Leu Pro 
    1550                 1555                 1560             


Ser Met  Lys Met Gln Lys Val  Met Pro Xaa Val Pro  Xaa Ser Gln 
    1565                 1570                 1575             


Val Xaa  Gly Pro Pro Pro Gln  Pro Pro Pro Ile Arg  Arg Glu Ile 
    1580                 1585                 1590             


Xaa Phe  Pro Pro Gly Ser Val  Glu Ala Ser Gln Pro  Val Leu Lys 
    1595                 1600                 1605             


Gln Arg  Arg Lys Ile Xaa Ser  Lys Asp Ile Val Xaa  Pro Glu Ala 
    1610                 1615                 1620             


Trp Arg  Val Met Met Ser Leu  Lys Ser Gly Leu Leu  Ala Glu Ser 
    1625                 1630                 1635             


Xaa Trp  Ala Leu Asp Xaa Ile  Asn Ile Leu Leu Tyr  Asp Asp Ser 
    1640                 1645                 1650             


Xaa Val  Ala Xaa Phe Asn Leu  Ser Gln Leu Ser Gly  Phe Leu Glu 
    1655                 1660                 1665             


Leu Leu  Val Glu Tyr Phe Arg  Lys Cys Leu Ile Asp  Ile Phe Gly 
    1670                 1675                 1680             


Ile Leu  Met Glu Tyr Glu Val  Gly Asp Pro Ser Gln  Lys Ala Leu 
    1685                 1690                 1695             


Asp His  Asn Ala Ala Arg Lys  Asp Asp Ser Gln Ser  Leu Ala Asp 
    1700                 1705                 1710             


Asp Ser  Gly Lys Glu Glu Glu  Asp Ala Glu Cys Ile  Asp Asp Asp 
    1715                 1720                 1725             


Glu Glu  Asp Glu Glu Asp Glu  Glu Glu Asp Ser Glu  Lys Xaa Glu 
    1730                 1735                 1740             


Ser Asp  Glu Lys Ser Ser Ile  Ala Leu Xaa Ala Pro  Asp Ala Ala 
    1745                 1750                 1755             


Ala Asp  Pro Lys Glu Lys Pro  Lys Gln Ala Ser Lys  Phe Asp Lys 
    1760                 1765                 1770             


Leu Pro  Ile Lys Ile Val Lys  Lys Asn Asn Leu Phe  Val Val Asp 
    1775                 1780                 1785             


Arg Ser  Asp Lys Leu Gly Arg  Val Gln Glu Phe Asn  Ser Gly Leu 
    1790                 1795                 1800             


Leu His  Trp Gln Leu Gly Gly  Gly Asp Xaa Xaa Glu  His Ile Gln 
    1805                 1810                 1815             


Xaa His  Phe Glu Ser Lys Met  Glu Ile Pro Pro Arg  Arg Arg Pro 
    1820                 1825                 1830             


Pro Pro  Pro Leu Ser Ser Ala  Gly Arg Lys Lys Glu  Gln Glu Gly 
    1835                 1840                 1845             


Lys Gly  Asp Ser Glu Glu Gln  Gln Glu Lys Ser Ile  Ile Ala Xaa 
    1850                 1855                 1860             


Ile Asp  Asp Val Leu Ser Ala  Arg Pro Gly Ala Leu  Pro Glu Asp 
    1865                 1870                 1875             


Ala Asn  Pro Gly Pro Gln Xaa  Glu Ser Ser Lys Phe  Pro Phe Gly 
    1880                 1885                 1890             


Ile Gln  Gln Ala Lys Ser His  Arg Asn Ile Lys Leu  Leu Glu Asp 
    1895                 1900                 1905             


Glu Pro  Arg Ser Arg Asp Glu  Xaa Pro Leu Cys Xaa  Ile Ala His 
    1910                 1915                 1920             


Trp Gln  Asp Ser Leu Ala Lys  Arg Cys Ile Cys Val  Ser Asn Ile 
    1925                 1930                 1935             


Val Arg  Ser Leu Ser Phe Val  Pro Gly Asn Asp Ala  Glu Met Ser 
    1940                 1945                 1950             


Lys His  Pro Gly Leu Val Leu  Ile Leu Gly Lys Leu  Ile Leu Leu 
    1955                 1960                 1965             


His His  Glu His Pro Glu Arg  Lys Arg Ala Pro Gln  Xaa Tyr Glu 
    1970                 1975                 1980             


Lys Glu  Glu Asp Glu Asp Lys  Gly Val Ala Cys Ser  Lys Asp Glu 
    1985                 1990                 1995             


Trp Trp  Trp Asp Cys Leu Glu  Val Leu Arg Asp Asn  Xaa Leu Val 
    2000                 2005                 2010             


Xaa Leu  Ala Asn Ile Ser Gly  Gln Leu Asp Leu Ser  Ala Tyr Xaa 
    2015                 2020                 2025             


Glu Ser  Ile Cys Leu Pro Ile  Leu Asp Gly Leu Leu  His Trp Met 
    2030                 2035                 2040             


Val Cys  Pro Ser Ala Glu Ala  Gln Asp Pro Phe Pro  Xaa Val Gly 
    2045                 2050                 2055             


Pro Asn  Ser Val Leu Ser Pro  Gln Arg Leu Val Leu  Glu Xaa Leu 
    2060                 2065                 2070             


Cys Lys  Leu Ser Ile Gln Asp  Asn Asn Val Asp Leu  Ile Leu Ala 
    2075                 2080                 2085             


Xaa Pro  Pro Phe Ser Arg Gln  Glu Lys Phe Tyr Ala  Xaa Leu Val 
    2090                 2095                 2100             


Arg Tyr  Val Gly Asp Arg Lys  Asn Pro Val Cys Arg  Glu Met Ser 
    2105                 2110                 2115             


Met Ala  Leu Leu Ser Asn Leu  Ala Gln Gly Asp Ala  Leu Ala Ala 
    2120                 2125                 2130             


Arg Ala  Ile Ala Val Gln Lys  Gly Ser Ile Gly Asn  Leu Ile Ser 
    2135                 2140                 2145             


Phe Leu  Glu Asp Gly Val Xaa  Met Ala Gln Tyr Gln  Gln Ser Gln 
    2150                 2155                 2160             


His Asn  Leu Met His Met Gln  Pro Pro Pro Leu Glu  Pro Pro Ser 
    2165                 2170                 2175             


Val Asp  Met Met Cys Arg Ala  Ala Lys Ala Leu Leu  Ala Met Ala 
    2180                 2185                 2190             


Arg Val  Asp Glu Asn Arg Ser  Glu Phe Leu Leu His  Glu Gly Arg 
    2195                 2200                 2205             


Leu Leu  Asp Ile Ser Ile Ser  Ala Val Leu Asn Ser  Leu Val Ala 
    2210                 2215                 2220             


Ser Val  Ile Cys Asp Val Leu  Phe Gln Ile Gly Gln  Leu 
    2225                 2230                 2235     


<210> 3107
<211> 2249
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1058)..(1058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1214)..(1214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1218)..(1218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1224)..(1224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1255)..(1255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1297)..(1297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1440)..(1440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1485)..(1485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1496)..(1496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1533)..(1533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1589)..(1589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1593)..(1593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1627)..(1627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1652)..(1652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1667)..(1667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1670)..(1670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1755)..(1755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1766)..(1766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1826)..(1827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1832)..(1832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1876)..(1876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1898)..(1898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1929)..(1929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1933)..(1933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1994)..(1994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2024)..(2024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2027)..(2027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2041)..(2041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2069)..(2069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2085)..(2085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2102)..(2102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2114)..(2114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2168)..(2168)
<223> Selenocysteine

<400> 3107
Met Ala His Asn Ala Gly Ala Ala Ala Ala Ala Gly Xaa His Ser Ala 
1               5                   10                  15      


Lys Ser Gly Gly Ser Glu Ala Ala Leu Lys Glu Gly Gly Ser Ala Ala 
            20                  25                  30          


Ala Leu Ser Ser Ser Ser Ser Ser Ser Ala Ala Ala Ala Ala Ala Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Gly Pro Gly Ser Ala Met Glu Xaa Gly Leu Leu 
    50                  55                  60                  


Pro Asn His Lys Leu Lys Xaa Val Gly Glu Ala Pro Ala Ala Pro Pro 
65                  70                  75                  80  


His Gln Gln His His His His His His Ala His His His His His His 
                85                  90                  95      


Ala His His Leu His His His His Ala Leu Gln Gln Gln Leu Asn Gln 
            100                 105                 110         


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        115                 120                 125             


Gln Gln Gln His Pro Ile Ser Asn Asn Asn Ser Leu Gly Gly Ala Gly 
    130                 135                 140                 


Gly Gly Ala Pro Gln Pro Gly Pro Asp Met Glu Gln Pro Gln His Gly 
145                 150                 155                 160 


Gly Ala Lys Asp Ser Ala Ala Gly Gly Gln Ala Asp Pro Pro Gly Pro 
                165                 170                 175     


Pro Leu Leu Ser Lys Pro Gly Asp Glu Asp Asp Ala Pro Pro Lys Met 
            180                 185                 190         


Gly Glu Pro Ala Gly Gly Arg Tyr Glu His Pro Gly Leu Gly Ala Leu 
        195                 200                 205             


Gly Xaa Gln Gln Pro Pro Val Ala Val Pro Gly Gly Gly Gly Gly Pro 
    210                 215                 220                 


Ala Ala Val Pro Glu Phe Asn Asn Tyr Tyr Gly Ser Ala Ala Pro Ala 
225                 230                 235                 240 


Ser Gly Gly Pro Gly Gly Arg Ala Gly Pro Cys Phe Asp Gln His Gly 
                245                 250                 255     


Gly Gln Gln Ser Pro Gly Met Gly Met Met His Ser Ala Ser Ala Ala 
            260                 265                 270         


Ala Ala Gly Ala Pro Gly Ser Met Asp Pro Leu Gln Asn Ser His Glu 
        275                 280                 285             


Gly Tyr Pro Asn Ser Gln Cys Asn His Tyr Pro Gly Tyr Ser Arg Pro 
    290                 295                 300                 


Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Ala Gly Gly Ala Gly Ala 
                325                 330                 335     


Gly Ala Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly 
            340                 345                 350         


Gly Gly Gly Gly Gly Tyr Gly Gly Ser Ser Ala Gly Tyr Gly Val Leu 
        355                 360                 365             


Ser Ser Pro Arg Gln Gln Gly Gly Gly Met Met Met Gly Pro Gly Gly 
    370                 375                 380                 


Gly Gly Ala Ala Ser Leu Ser Lys Ala Ala Ala Gly Ser Ala Ala Gly 
385                 390                 395                 400 


Gly Phe Gln Arg Phe Ala Gly Gln Asn Gln His Pro Ser Gly Ala Xaa 
                405                 410                 415     


Pro Xaa Leu Asn Gln Leu Leu Xaa Ser Pro Ser Pro Met Met Arg Ser 
            420                 425                 430         


Tyr Gly Gly Ser Tyr Pro Glu Tyr Ser Ser Pro Ser Ala Pro Pro Pro 
        435                 440                 445             


Pro Pro Ser Gln Pro Gln Ser Gln Ala Ala Ala Ala Gly Ala Ala Ala 
    450                 455                 460                 


Gly Gly Gln Gln Ala Ala Ala Gly Met Gly Leu Gly Lys Asp Met Gly 
465                 470                 475                 480 


Ala Gln Tyr Ala Ala Ala Ser Pro Ala Trp Ala Ala Ala Gln Gln Arg 
                485                 490                 495     


Ser His Pro Ala Met Ser Pro Gly Xaa Pro Gly Pro Xaa Met Gly Arg 
            500                 505                 510         


Ser Gln Gly Ser Pro Met Asp Pro Met Val Met Lys Arg Pro Gln Leu 
        515                 520                 525             


Tyr Gly Met Gly Ser Asn Pro His Ser Gln Pro Gln Gln Ser Ser Pro 
    530                 535                 540                 


Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly Pro Gln Arg Tyr Pro Ile 
545                 550                 555                 560 


Gly Ile Gln Gly Arg Xaa Pro Gly Ala Met Ala Gly Met Gln Tyr Pro 
                565                 570                 575     


Gln Gln Gln Asp Ser Gly Asp Ala Xaa Trp Lys Glu Xaa Phe Trp Leu 
            580                 585                 590         


Met Pro Pro Gln Tyr Gly Gln Gln Gly Val Ser Gly Tyr Cys Gln Gln 
        595                 600                 605             


Gly Gln Gln Pro Tyr Tyr Ser Gln Gln Pro Gln Pro Pro His Leu Pro 
    610                 615                 620                 


Pro Gln Ala Gln Tyr Leu Pro Ser Gln Ser Gln Gln Arg Tyr Gln Pro 
625                 630                 635                 640 


Gln Gln Asp Met Ser Gln Glu Gly Tyr Gly Xaa Arg Ser Gln Pro Pro 
                645                 650                 655     


Leu Ala Pro Gly Lys Pro Asn His Glu Asp Leu Asn Leu Ile Gln Gln 
            660                 665                 670         


Glu Arg Pro Ser Ser Leu Pro Asp Leu Ser Gly Ser Ile Asp Asp Leu 
        675                 680                 685             


Pro Xaa Gly Xaa Glu Ala Xaa Leu Ser Ser Ala Val Ser Ala Ser Gly 
    690                 695                 700                 


Ser Xaa Ser Ser Gln Gly Asp Gln Ser Asn Pro Ala Gln Ser Pro Phe 
705                 710                 715                 720 


Ser Pro His Ala Ser Pro His Leu Ser Ser Ile Pro Gly Gly Pro Ser 
                725                 730                 735     


Pro Ser Pro Val Gly Ser Pro Val Gly Ser Asn Gln Ser Arg Ser Gly 
            740                 745                 750         


Pro Ile Ser Pro Ala Ser Ile Pro Gly Ser Gln Met Pro Pro Gln Pro 
        755                 760                 765             


Pro Gly Ser Gln Ser Glu Ser Ser Ser His Pro Ala Leu Ser Gln Ser 
    770                 775                 780                 


Pro Met Pro Gln Glu Arg Gly Phe Met Ala Gly Xaa Gln Arg Asn Pro 
785                 790                 795                 800 


Gln Met Ala Gln Tyr Gly Pro Gln Gln Xaa Gly Pro Ser Met Ser Pro 
                805                 810                 815     


His Pro Ser Pro Gly Gly Gln Met His Ala Gly Ile Ser Ser Phe Gln 
            820                 825                 830         


Gln Ser Asn Ser Ser Gly Xaa Tyr Gly Pro Gln Met Ser Gln Tyr Gly 
        835                 840                 845             


Pro Gln Gly Asn Tyr Ser Arg Pro Pro Ala Tyr Ser Gly Val Pro Ser 
    850                 855                 860                 


Ala Ser Tyr Ser Gly Pro Gly Pro Gly Met Gly Ile Ser Ala Asn Asn 
865                 870                 875                 880 


Gln Met His Gly Gln Gly Pro Ser Gln Pro Cys Gly Ala Val Pro Leu 
                885                 890                 895     


Gly Arg Met Pro Ser Ala Gly Met Gln Asn Arg Pro Phe Pro Gly Asn 
            900                 905                 910         


Met Ser Ser Met Xaa Pro Ser Ser Pro Gly Met Ser Gln Gln Gly Gly 
        915                 920                 925             


Pro Gly Met Gly Pro Pro Met Pro Xaa Val Asn Arg Lys Ala Gln Glu 
    930                 935                 940                 


Ala Ala Ala Ala Val Met Gln Ala Ala Ala Asn Ser Ala Gln Ser Arg 
945                 950                 955                 960 


Gln Gly Ser Phe Pro Gly Met Asn Gln Ser Gly Leu Met Ala Ser Ser 
                965                 970                 975     


Ser Pro Tyr Ser Gln Pro Met Asn Asn Ser Ser Ser Leu Met Asn Xaa 
            980                 985                 990         


Gln Ala Pro Pro Tyr Ser Met Ala  Pro Ala Met Val Asn  Ser Ser Ala 
        995                 1000                 1005             


Ala Ser  Val Gly Leu Ala Asp  Met Met Ser Pro Gly  Glu Ser Lys 
    1010                 1015                 1020             


Leu Pro  Leu Pro Leu Lys Ala  Asp Gly Lys Glu Glu  Gly Xaa Pro 
    1025                 1030                 1035             


Gln Pro  Glu Ser Lys Ser Lys  Lys Ser Ser Ser Ser  Xaa Xaa Xaa 
    1040                 1045                 1050             


Gly Glu  Lys Ile Xaa Lys Val  Tyr Glu Leu Gly Asn  Glu Pro Glu 
    1055                 1060                 1065             


Arg Lys  Leu Trp Val Asp Arg  Tyr Leu Xaa Phe Met  Glu Glu Arg 
    1070                 1075                 1080             


Gly Ser  Pro Val Ser Ser Leu  Pro Ala Val Gly Lys  Lys Pro Leu 
    1085                 1090                 1095             


Asp Leu  Phe Arg Leu Tyr Val  Cys Val Lys Glu Ile  Gly Gly Leu 
    1100                 1105                 1110             


Ala Gln  Val Asn Lys Asn Lys  Lys Trp Arg Glu Leu  Ala Xaa Asn 
    1115                 1120                 1125             


Leu Asn  Val Gly Xaa Ser Ser  Ser Ala Ala Ser Ser  Leu Lys Lys 
    1130                 1135                 1140             


Gln Tyr  Ile Gln Tyr Leu Phe  Ala Phe Glu Cys Lys  Ile Glu Arg 
    1145                 1150                 1155             


Gly Glu  Glu Pro Pro Pro Glu  Val Phe Ser Xaa Gly  Asp Xaa Lys 
    1160                 1165                 1170             


Lys Gln  Pro Lys Leu Gln Pro  Pro Ser Pro Ala Asn  Ser Gly Ser 
    1175                 1180                 1185             


Leu Gln  Gly Pro Gln Xaa Pro  Gln Ser Xaa Gly Ser  Asn Ser Met 
    1190                 1195                 1200             


Ala Glu  Val Pro Gly Asp Leu  Lys Pro Pro Xaa Pro  Ala Ser Xaa 
    1205                 1210                 1215             


Pro His  Gly Gln Met Xaa Pro  Met Gln Gly Gly Arg  Ser Ser Xaa 
    1220                 1225                 1230             


Ile Ser  Val His Asp Pro Phe  Ser Asp Val Ser Asp  Ser Ser Phe 
    1235                 1240                 1245             


Pro Lys  Arg Asn Ser Met Xaa  Pro Asn Ala Pro Tyr  Gln Gln Gly 
    1250                 1255                 1260             


Met Ser  Met Pro Asp Val Met  Gly Arg Met Pro Tyr  Glu Pro Asn 
    1265                 1270                 1275             


Lys Asp  Pro Phe Gly Gly Met  Arg Lys Val Pro Gly  Ser Ser Glu 
    1280                 1285                 1290             


Pro Phe  Met Xaa Gln Gly Gln  Met Pro Asn Ser Ser  Met Gln Asp 
    1295                 1300                 1305             


Met Tyr  Asn Gln Ser Pro Ser  Gly Ala Met Ser Asn  Leu Gly Met 
    1310                 1315                 1320             


Gly Gln  Arg Gln Gln Phe Pro  Tyr Gly Ala Ser Tyr  Asp Arg Arg 
    1325                 1330                 1335             


His Glu  Pro Tyr Gly Gln Gln  Tyr Pro Gly Gln Gly  Pro Pro Ser 
    1340                 1345                 1350             


Gly Gln  Pro Pro Tyr Gly Gly  His Gln Pro Gly Leu  Tyr Pro Gln 
    1355                 1360                 1365             


Gln Pro  Asn Tyr Lys Arg His  Met Asp Gly Met Tyr  Gly Pro Pro 
    1370                 1375                 1380             


Ala Lys  Arg His Glu Gly Asp  Met Tyr Asn Met Gln  Tyr Ser Ser 
    1385                 1390                 1395             


Gln Gln  Gln Glu Met Tyr Asn  Gln Tyr Gly Gly Ser  Tyr Ser Gly 
    1400                 1405                 1410             


Pro Asp  Arg Arg Pro Ile Gln  Gly Gln Tyr Pro Tyr  Pro Tyr Ser 
    1415                 1420                 1425             


Arg Glu  Arg Met Gln Gly Pro  Gly Gln Ile Gln Xaa  His Gly Ile 
    1430                 1435                 1440             


Pro Pro  Gln Met Met Gly Gly  Pro Leu Gln Ser Ser  Ser Ser Glu 
    1445                 1450                 1455             


Gly Pro  Gln Gln Asn Met Trp  Ala Ala Arg Asn Asp  Met Pro Tyr 
    1460                 1465                 1470             


Pro Tyr  Gln Asn Arg Gln Gly  Pro Gly Gly Pro Xaa  Gln Ala Pro 
    1475                 1480                 1485             


Pro Tyr  Pro Gly Met Asn Arg  Xaa Asp Asp Met Met  Val Pro Asp 
    1490                 1495                 1500             


Gln Arg  Ile Asn His Glu Ser  Gln Trp Pro Ser His  Val Ser Gln 
    1505                 1510                 1515             


Arg Gln  Pro Tyr Met Ser Ser  Ser Ala Ser Met Gln  Pro Ile Xaa 
    1520                 1525                 1530             


Arg Pro  Pro Gln Pro Ser Tyr  Gln Xaa Pro Pro Ser  Leu Pro Asn 
    1535                 1540                 1545             


His Ile  Ser Arg Ala Pro Ser  Pro Ala Ser Phe Gln  Arg Ser Leu 
    1550                 1555                 1560             


Glu Asn  Arg Met Ser Pro Ser  Lys Ser Pro Phe Leu  Pro Ser Met 
    1565                 1570                 1575             


Lys Met  Gln Lys Val Met Pro  Xaa Val Pro Xaa Ser  Gln Val Xaa 
    1580                 1585                 1590             


Gly Pro  Pro Pro Gln Pro Pro  Pro Ile Arg Arg Glu  Ile Xaa Phe 
    1595                 1600                 1605             


Pro Pro  Gly Ser Val Glu Ala  Ser Gln Pro Val Leu  Lys Gln Arg 
    1610                 1615                 1620             


Arg Lys  Ile Xaa Ser Lys Asp  Ile Val Xaa Pro Glu  Ala Trp Arg 
    1625                 1630                 1635             


Val Met  Met Ser Leu Lys Ser  Gly Leu Leu Ala Glu  Ser Xaa Trp 
    1640                 1645                 1650             


Ala Leu  Asp Xaa Ile Asn Ile  Leu Leu Tyr Asp Asp  Ser Xaa Val 
    1655                 1660                 1665             


Ala Xaa  Phe Asn Leu Ser Gln  Leu Ser Gly Phe Leu  Glu Leu Leu 
    1670                 1675                 1680             


Val Glu  Tyr Phe Arg Lys Cys  Leu Ile Asp Ile Phe  Gly Ile Leu 
    1685                 1690                 1695             


Met Glu  Tyr Glu Val Gly Asp  Pro Ser Gln Lys Ala  Leu Asp His 
    1700                 1705                 1710             


Asn Ala  Ala Arg Lys Asp Asp  Ser Gln Ser Leu Ala  Asp Asp Ser 
    1715                 1720                 1725             


Gly Lys  Glu Glu Glu Asp Ala  Glu Cys Ile Asp Asp  Asp Glu Glu 
    1730                 1735                 1740             


Asp Glu  Glu Asp Glu Glu Glu  Asp Ser Glu Lys Xaa  Glu Ser Asp 
    1745                 1750                 1755             


Glu Lys  Ser Ser Ile Ala Leu  Xaa Ala Pro Asp Ala  Ala Ala Asp 
    1760                 1765                 1770             


Pro Lys  Glu Lys Pro Lys Gln  Ala Ser Lys Phe Asp  Lys Leu Pro 
    1775                 1780                 1785             


Ile Lys  Ile Val Lys Lys Asn  Asn Leu Phe Val Val  Asp Arg Ser 
    1790                 1795                 1800             


Asp Lys  Leu Gly Arg Val Gln  Glu Phe Asn Ser Gly  Leu Leu His 
    1805                 1810                 1815             


Trp Gln  Leu Gly Gly Gly Asp  Xaa Xaa Glu His Ile  Gln Xaa His 
    1820                 1825                 1830             


Phe Glu  Ser Lys Met Glu Ile  Pro Pro Arg Arg Arg  Pro Pro Pro 
    1835                 1840                 1845             


Pro Leu  Ser Ser Ala Gly Arg  Lys Lys Glu Gln Glu  Gly Lys Gly 
    1850                 1855                 1860             


Asp Ser  Glu Glu Gln Gln Glu  Lys Ser Ile Ile Ala  Xaa Ile Asp 
    1865                 1870                 1875             


Asp Val  Leu Ser Ala Arg Pro  Gly Ala Leu Pro Glu  Asp Ala Asn 
    1880                 1885                 1890             


Pro Gly  Pro Gln Xaa Glu Ser  Ser Lys Phe Pro Phe  Gly Ile Gln 
    1895                 1900                 1905             


Gln Ala  Lys Ser His Arg Asn  Ile Lys Leu Leu Glu  Asp Glu Pro 
    1910                 1915                 1920             


Arg Ser  Arg Asp Glu Xaa Pro  Leu Cys Xaa Ile Ala  His Trp Gln 
    1925                 1930                 1935             


Asp Ser  Leu Ala Lys Arg Cys  Ile Cys Val Ser Asn  Ile Val Arg 
    1940                 1945                 1950             


Ser Leu  Ser Phe Val Pro Gly  Asn Asp Ala Glu Met  Ser Lys His 
    1955                 1960                 1965             


Pro Gly  Leu Val Leu Ile Leu  Gly Lys Leu Ile Leu  Leu His His 
    1970                 1975                 1980             


Glu His  Pro Glu Arg Lys Arg  Ala Pro Gln Xaa Tyr  Glu Lys Glu 
    1985                 1990                 1995             


Glu Asp  Glu Asp Lys Gly Val  Ala Cys Ser Lys Asp  Glu Trp Trp 
    2000                 2005                 2010             


Trp Asp  Cys Leu Glu Val Leu  Arg Asp Asn Xaa Leu  Val Xaa Leu 
    2015                 2020                 2025             


Ala Asn  Ile Ser Gly Gln Leu  Asp Leu Ser Ala Tyr  Xaa Glu Ser 
    2030                 2035                 2040             


Ile Cys  Leu Pro Ile Leu Asp  Gly Leu Leu His Trp  Met Val Cys 
    2045                 2050                 2055             


Pro Ser  Ala Glu Ala Gln Asp  Pro Phe Pro Xaa Val  Gly Pro Asn 
    2060                 2065                 2070             


Ser Val  Leu Ser Pro Gln Arg  Leu Val Leu Glu Xaa  Leu Cys Lys 
    2075                 2080                 2085             


Leu Ser  Ile Gln Asp Asn Asn  Val Asp Leu Ile Leu  Ala Xaa Pro 
    2090                 2095                 2100             


Pro Phe  Ser Arg Gln Glu Lys  Phe Tyr Ala Xaa Leu  Val Arg Tyr 
    2105                 2110                 2115             


Val Gly  Asp Arg Lys Asn Pro  Val Cys Arg Glu Met  Ser Met Ala 
    2120                 2125                 2130             


Leu Leu  Ser Asn Leu Ala Gln  Gly Asp Ala Leu Ala  Ala Arg Ala 
    2135                 2140                 2145             


Ile Ala  Val Gln Lys Gly Ser  Ile Gly Asn Leu Ile  Ser Phe Leu 
    2150                 2155                 2160             


Glu Asp  Gly Val Xaa Met Ala  Gln Tyr Gln Gln Ser  Gln His Asn 
    2165                 2170                 2175             


Leu Met  His Met Gln Pro Pro  Pro Leu Glu Pro Pro  Ser Val Asp 
    2180                 2185                 2190             


Met Met  Cys Arg Ala Ala Lys  Ala Leu Leu Ala Met  Ala Arg Val 
    2195                 2200                 2205             


Asp Glu  Asn Arg Ser Glu Phe  Leu Leu His Glu Gly  Arg Leu Leu 
    2210                 2215                 2220             


Asp Ile  Ser Ile Ser Ala Val  Leu Asn Ser Leu Val  Ala Ser Val 
    2225                 2230                 2235             


Ile Cys  Asp Val Leu Phe Gln  Ile Gly Gln Leu 
    2240                 2245                 


<210> 3108
<211> 2289
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1091)..(1093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1173)..(1173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1234)..(1234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1238)..(1238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1273)..(1273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1480)..(1480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1525)..(1525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1536)..(1536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1626)..(1626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1629)..(1629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1647)..(1647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1667)..(1667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1673)..(1673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1692)..(1692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1697)..(1697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1707)..(1707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1710)..(1710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1795)..(1795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1806)..(1806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1866)..(1867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1872)..(1872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1916)..(1916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1938)..(1938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1969)..(1969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1973)..(1973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2034)..(2034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2064)..(2064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2067)..(2067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2081)..(2081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2109)..(2109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2125)..(2125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2142)..(2142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2154)..(2154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2208)..(2208)
<223> Selenocysteine

<400> 3108
Met Ala His Asn Ala Gly Ala Ala Ala Ala Ala Gly Xaa His Ser Ala 
1               5                   10                  15      


Lys Ser Gly Gly Ser Glu Ala Ala Leu Lys Glu Gly Gly Ser Ala Ala 
            20                  25                  30          


Ala Leu Ser Ser Ser Ser Ser Ser Ser Ala Ala Ala Ala Ala Ala Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Gly Pro Gly Ser Ala Met Glu Xaa Gly Leu Leu 
    50                  55                  60                  


Pro Asn His Lys Leu Lys Xaa Val Gly Glu Ala Pro Ala Ala Pro Pro 
65                  70                  75                  80  


His Gln Gln His His His His His His Ala His His His His His His 
                85                  90                  95      


Ala His His Leu His His His His Ala Leu Gln Gln Gln Leu Asn Gln 
            100                 105                 110         


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        115                 120                 125             


Gln Gln Gln His Pro Ile Ser Asn Asn Asn Ser Leu Gly Gly Ala Gly 
    130                 135                 140                 


Gly Gly Ala Pro Gln Pro Gly Pro Asp Met Glu Gln Pro Gln His Gly 
145                 150                 155                 160 


Gly Ala Lys Asp Ser Ala Ala Gly Gly Gln Ala Asp Pro Pro Gly Pro 
                165                 170                 175     


Pro Leu Leu Ser Lys Pro Gly Asp Glu Asp Asp Ala Pro Pro Lys Met 
            180                 185                 190         


Gly Glu Pro Ala Gly Gly Arg Tyr Glu His Pro Gly Leu Gly Ala Leu 
        195                 200                 205             


Gly Xaa Gln Gln Pro Pro Val Ala Val Pro Gly Gly Gly Gly Gly Pro 
    210                 215                 220                 


Ala Ala Val Pro Glu Phe Asn Asn Tyr Tyr Gly Ser Ala Ala Pro Ala 
225                 230                 235                 240 


Ser Gly Gly Pro Gly Gly Arg Ala Gly Pro Cys Phe Asp Gln His Gly 
                245                 250                 255     


Gly Gln Gln Ser Pro Gly Met Gly Met Met His Ser Ala Ser Ala Ala 
            260                 265                 270         


Ala Ala Gly Ala Pro Gly Ser Met Asp Pro Leu Gln Asn Ser His Glu 
        275                 280                 285             


Gly Tyr Pro Asn Ser Gln Cys Asn His Tyr Pro Gly Tyr Ser Arg Pro 
    290                 295                 300                 


Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Ala Gly Gly Ala Gly Ala 
                325                 330                 335     


Gly Ala Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly 
            340                 345                 350         


Gly Gly Gly Gly Gly Tyr Gly Gly Ser Ser Ala Gly Tyr Gly Val Leu 
        355                 360                 365             


Ser Ser Pro Arg Gln Gln Gly Gly Gly Met Met Met Gly Pro Gly Gly 
    370                 375                 380                 


Gly Gly Ala Ala Ser Leu Ser Lys Ala Ala Ala Gly Ser Ala Ala Gly 
385                 390                 395                 400 


Gly Phe Gln Arg Phe Ala Gly Gln Asn Gln His Pro Ser Gly Ala Xaa 
                405                 410                 415     


Pro Xaa Leu Asn Gln Leu Leu Xaa Ser Pro Ser Pro Met Met Arg Ser 
            420                 425                 430         


Tyr Gly Gly Ser Tyr Pro Glu Tyr Ser Ser Pro Ser Ala Pro Pro Pro 
        435                 440                 445             


Pro Pro Ser Gln Pro Gln Ser Gln Ala Ala Ala Ala Gly Ala Ala Ala 
    450                 455                 460                 


Gly Gly Gln Gln Ala Ala Ala Gly Met Gly Leu Gly Lys Asp Met Gly 
465                 470                 475                 480 


Ala Gln Tyr Ala Ala Ala Ser Pro Ala Trp Ala Ala Ala Gln Gln Arg 
                485                 490                 495     


Ser His Pro Ala Met Ser Pro Gly Xaa Pro Gly Pro Xaa Met Gly Arg 
            500                 505                 510         


Ser Gln Gly Ser Pro Met Asp Pro Met Val Met Lys Arg Pro Gln Leu 
        515                 520                 525             


Tyr Gly Met Gly Ser Asn Pro His Ser Gln Pro Gln Gln Ser Ser Pro 
    530                 535                 540                 


Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly Pro Gln Arg Tyr Pro Ile 
545                 550                 555                 560 


Gly Ile Gln Gly Arg Xaa Pro Gly Ala Met Ala Gly Met Gln Tyr Pro 
                565                 570                 575     


Gln Gln Gln Met Pro Pro Gln Tyr Gly Gln Gln Gly Val Ser Gly Tyr 
            580                 585                 590         


Cys Gln Gln Gly Gln Gln Pro Tyr Tyr Ser Gln Gln Pro Gln Pro Pro 
        595                 600                 605             


His Leu Pro Pro Gln Ala Gln Tyr Leu Pro Ser Gln Ser Gln Gln Arg 
    610                 615                 620                 


Tyr Gln Pro Gln Gln Asp Met Ser Gln Glu Gly Tyr Gly Xaa Arg Ser 
625                 630                 635                 640 


Gln Pro Pro Leu Ala Pro Gly Lys Pro Asn His Glu Asp Leu Asn Leu 
                645                 650                 655     


Ile Gln Gln Glu Arg Pro Ser Ser Leu Pro Asp Leu Ser Gly Ser Ile 
            660                 665                 670         


Asp Asp Leu Pro Xaa Gly Xaa Glu Ala Xaa Leu Ser Ser Ala Val Ser 
        675                 680                 685             


Ala Ser Gly Ser Xaa Ser Ser Gln Gly Asp Gln Ser Asn Pro Ala Gln 
    690                 695                 700                 


Ser Pro Phe Ser Pro His Ala Ser Pro His Leu Ser Ser Ile Pro Gly 
705                 710                 715                 720 


Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Val Gly Ser Asn Gln Ser 
                725                 730                 735     


Arg Ser Gly Pro Ile Ser Pro Ala Ser Ile Pro Gly Ser Gln Met Pro 
            740                 745                 750         


Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser Ser Ser His Pro Ala Leu 
        755                 760                 765             


Ser Gln Ser Pro Met Pro Gln Glu Arg Gly Phe Met Ala Gly Xaa Gln 
    770                 775                 780                 


Arg Asn Pro Gln Met Ala Gln Tyr Gly Pro Gln Gln Xaa Gly Pro Ser 
785                 790                 795                 800 


Met Ser Pro His Pro Ser Pro Gly Gly Gln Met His Ala Gly Ile Ser 
                805                 810                 815     


Ser Phe Gln Gln Ser Asn Ser Ser Gly Xaa Tyr Gly Pro Gln Met Ser 
            820                 825                 830         


Gln Tyr Gly Pro Gln Gly Asn Tyr Ser Arg Pro Pro Ala Tyr Ser Gly 
        835                 840                 845             


Val Pro Ser Ala Ser Tyr Ser Gly Pro Gly Pro Gly Met Gly Ile Ser 
    850                 855                 860                 


Ala Asn Asn Gln Met His Gly Gln Gly Pro Ser Gln Pro Cys Gly Ala 
865                 870                 875                 880 


Val Pro Leu Gly Arg Met Pro Ser Ala Gly Met Gln Asn Arg Pro Phe 
                885                 890                 895     


Pro Gly Asn Met Ser Ser Met Xaa Pro Ser Ser Pro Gly Met Ser Gln 
            900                 905                 910         


Gln Gly Gly Pro Gly Met Gly Pro Pro Met Pro Xaa Val Asn Arg Lys 
        915                 920                 925             


Ala Gln Glu Ala Ala Ala Ala Val Met Gln Ala Ala Ala Asn Ser Ala 
    930                 935                 940                 


Gln Ser Arg Gln Gly Ser Phe Pro Gly Met Asn Gln Ser Gly Leu Met 
945                 950                 955                 960 


Ala Ser Ser Ser Pro Tyr Ser Gln Pro Met Asn Asn Ser Ser Ser Leu 
                965                 970                 975     


Met Asn Xaa Gln Ala Pro Pro Tyr Ser Met Ala Pro Ala Met Val Asn 
            980                 985                 990         


Ser Ser Ala Ala Ser Val Gly Leu  Ala Asp Met Met Ser  Pro Gly Glu 
        995                 1000                 1005             


Ser Lys  Leu Pro Leu Pro Leu  Lys Ala Asp Gly Lys  Glu Glu Gly 
    1010                 1015                 1020             


Xaa Pro  Gln Pro Glu Ser Lys  Ser Lys Asp Ser Tyr  Ser Ser Gln 
    1025                 1030                 1035             


Gly Ile  Ser Gln Pro Pro Xaa  Pro Gly Asn Leu Pro  Val Pro Ser 
    1040                 1045                 1050             


Pro Met  Ser Pro Ser Ser Ala  Ser Ile Ser Ser Phe  His Gly Asp 
    1055                 1060                 1065             


Glu Ser  Asp Ser Ile Ser Ser  Pro Gly Trp Pro Lys  Xaa Pro Ser 
    1070                 1075                 1080             


Ser Pro  Lys Ser Ser Ser Ser  Xaa Xaa Xaa Gly Glu  Lys Ile Xaa 
    1085                 1090                 1095             


Lys Val  Tyr Glu Leu Gly Asn  Glu Pro Glu Arg Lys  Leu Trp Val 
    1100                 1105                 1110             


Asp Arg  Tyr Leu Xaa Phe Met  Glu Glu Arg Gly Ser  Pro Val Ser 
    1115                 1120                 1125             


Ser Leu  Pro Ala Val Gly Lys  Lys Pro Leu Asp Leu  Phe Arg Leu 
    1130                 1135                 1140             


Tyr Val  Cys Val Lys Glu Ile  Gly Gly Leu Ala Gln  Val Asn Lys 
    1145                 1150                 1155             


Asn Lys  Lys Trp Arg Glu Leu  Ala Xaa Asn Leu Asn  Val Gly Xaa 
    1160                 1165                 1170             


Ser Ser  Ser Ala Ala Ser Ser  Leu Lys Lys Gln Tyr  Ile Gln Tyr 
    1175                 1180                 1185             


Leu Phe  Ala Phe Glu Cys Lys  Ile Glu Arg Gly Glu  Glu Pro Pro 
    1190                 1195                 1200             


Pro Glu  Val Phe Ser Xaa Gly  Asp Xaa Lys Lys Gln  Pro Lys Leu 
    1205                 1210                 1215             


Gln Pro  Pro Ser Pro Ala Asn  Ser Gly Ser Leu Gln  Gly Pro Gln 
    1220                 1225                 1230             


Xaa Pro  Gln Ser Xaa Gly Ser  Asn Ser Met Ala Glu  Val Pro Gly 
    1235                 1240                 1245             


Asp Leu  Lys Pro Pro Xaa Pro  Ala Ser Xaa Pro His  Gly Gln Met 
    1250                 1255                 1260             


Xaa Pro  Met Gln Gly Gly Arg  Ser Ser Xaa Ile Ser  Val His Asp 
    1265                 1270                 1275             


Pro Phe  Ser Asp Val Ser Asp  Ser Ser Phe Pro Lys  Arg Asn Ser 
    1280                 1285                 1290             


Met Xaa  Pro Asn Ala Pro Tyr  Gln Gln Gly Met Ser  Met Pro Asp 
    1295                 1300                 1305             


Val Met  Gly Arg Met Pro Tyr  Glu Pro Asn Lys Asp  Pro Phe Gly 
    1310                 1315                 1320             


Gly Met  Arg Lys Val Pro Gly  Ser Ser Glu Pro Phe  Met Xaa Gln 
    1325                 1330                 1335             


Gly Gln  Met Pro Asn Ser Ser  Met Gln Asp Met Tyr  Asn Gln Ser 
    1340                 1345                 1350             


Pro Ser  Gly Ala Met Ser Asn  Leu Gly Met Gly Gln  Arg Gln Gln 
    1355                 1360                 1365             


Phe Pro  Tyr Gly Ala Ser Tyr  Asp Arg Arg His Glu  Pro Tyr Gly 
    1370                 1375                 1380             


Gln Gln  Tyr Pro Gly Gln Gly  Pro Pro Ser Gly Gln  Pro Pro Tyr 
    1385                 1390                 1395             


Gly Gly  His Gln Pro Gly Leu  Tyr Pro Gln Gln Pro  Asn Tyr Lys 
    1400                 1405                 1410             


Arg His  Met Asp Gly Met Tyr  Gly Pro Pro Ala Lys  Arg His Glu 
    1415                 1420                 1425             


Gly Asp  Met Tyr Asn Met Gln  Tyr Ser Ser Gln Gln  Gln Glu Met 
    1430                 1435                 1440             


Tyr Asn  Gln Tyr Gly Gly Ser  Tyr Ser Gly Pro Asp  Arg Arg Pro 
    1445                 1450                 1455             


Ile Gln  Gly Gln Tyr Pro Tyr  Pro Tyr Ser Arg Glu  Arg Met Gln 
    1460                 1465                 1470             


Gly Pro  Gly Gln Ile Gln Xaa  His Gly Ile Pro Pro  Gln Met Met 
    1475                 1480                 1485             


Gly Gly  Pro Leu Gln Ser Ser  Ser Ser Glu Gly Pro  Gln Gln Asn 
    1490                 1495                 1500             


Met Trp  Ala Ala Arg Asn Asp  Met Pro Tyr Pro Tyr  Gln Asn Arg 
    1505                 1510                 1515             


Gln Gly  Pro Gly Gly Pro Xaa  Gln Ala Pro Pro Tyr  Pro Gly Met 
    1520                 1525                 1530             


Asn Arg  Xaa Asp Asp Met Met  Val Pro Asp Gln Arg  Ile Asn His 
    1535                 1540                 1545             


Glu Ser  Gln Trp Pro Ser His  Val Ser Gln Arg Gln  Pro Tyr Met 
    1550                 1555                 1560             


Ser Ser  Ser Ala Ser Met Gln  Pro Ile Xaa Arg Pro  Pro Gln Pro 
    1565                 1570                 1575             


Ser Tyr  Gln Xaa Pro Pro Ser  Leu Pro Asn His Ile  Ser Arg Ala 
    1580                 1585                 1590             


Pro Ser  Pro Ala Ser Phe Gln  Arg Ser Leu Glu Asn  Arg Met Ser 
    1595                 1600                 1605             


Pro Ser  Lys Ser Pro Phe Leu  Pro Ser Met Lys Met  Gln Lys Val 
    1610                 1615                 1620             


Met Pro  Xaa Val Pro Xaa Ser  Gln Val Xaa Gly Pro  Pro Pro Gln 
    1625                 1630                 1635             


Pro Pro  Pro Ile Arg Arg Glu  Ile Xaa Phe Pro Pro  Gly Ser Val 
    1640                 1645                 1650             


Glu Ala  Ser Gln Pro Val Leu  Lys Gln Arg Arg Lys  Ile Xaa Ser 
    1655                 1660                 1665             


Lys Asp  Ile Val Xaa Pro Glu  Ala Trp Arg Val Met  Met Ser Leu 
    1670                 1675                 1680             


Lys Ser  Gly Leu Leu Ala Glu  Ser Xaa Trp Ala Leu  Asp Xaa Ile 
    1685                 1690                 1695             


Asn Ile  Leu Leu Tyr Asp Asp  Ser Xaa Val Ala Xaa  Phe Asn Leu 
    1700                 1705                 1710             


Ser Gln  Leu Ser Gly Phe Leu  Glu Leu Leu Val Glu  Tyr Phe Arg 
    1715                 1720                 1725             


Lys Cys  Leu Ile Asp Ile Phe  Gly Ile Leu Met Glu  Tyr Glu Val 
    1730                 1735                 1740             


Gly Asp  Pro Ser Gln Lys Ala  Leu Asp His Asn Ala  Ala Arg Lys 
    1745                 1750                 1755             


Asp Asp  Ser Gln Ser Leu Ala  Asp Asp Ser Gly Lys  Glu Glu Glu 
    1760                 1765                 1770             


Asp Ala  Glu Cys Ile Asp Asp  Asp Glu Glu Asp Glu  Glu Asp Glu 
    1775                 1780                 1785             


Glu Glu  Asp Ser Glu Lys Xaa  Glu Ser Asp Glu Lys  Ser Ser Ile 
    1790                 1795                 1800             


Ala Leu  Xaa Ala Pro Asp Ala  Ala Ala Asp Pro Lys  Glu Lys Pro 
    1805                 1810                 1815             


Lys Gln  Ala Ser Lys Phe Asp  Lys Leu Pro Ile Lys  Ile Val Lys 
    1820                 1825                 1830             


Lys Asn  Asn Leu Phe Val Val  Asp Arg Ser Asp Lys  Leu Gly Arg 
    1835                 1840                 1845             


Val Gln  Glu Phe Asn Ser Gly  Leu Leu His Trp Gln  Leu Gly Gly 
    1850                 1855                 1860             


Gly Asp  Xaa Xaa Glu His Ile  Gln Xaa His Phe Glu  Ser Lys Met 
    1865                 1870                 1875             


Glu Ile  Pro Pro Arg Arg Arg  Pro Pro Pro Pro Leu  Ser Ser Ala 
    1880                 1885                 1890             


Gly Arg  Lys Lys Glu Gln Glu  Gly Lys Gly Asp Ser  Glu Glu Gln 
    1895                 1900                 1905             


Gln Glu  Lys Ser Ile Ile Ala  Xaa Ile Asp Asp Val  Leu Ser Ala 
    1910                 1915                 1920             


Arg Pro  Gly Ala Leu Pro Glu  Asp Ala Asn Pro Gly  Pro Gln Xaa 
    1925                 1930                 1935             


Glu Ser  Ser Lys Phe Pro Phe  Gly Ile Gln Gln Ala  Lys Ser His 
    1940                 1945                 1950             


Arg Asn  Ile Lys Leu Leu Glu  Asp Glu Pro Arg Ser  Arg Asp Glu 
    1955                 1960                 1965             


Xaa Pro  Leu Cys Xaa Ile Ala  His Trp Gln Asp Ser  Leu Ala Lys 
    1970                 1975                 1980             


Arg Cys  Ile Cys Val Ser Asn  Ile Val Arg Ser Leu  Ser Phe Val 
    1985                 1990                 1995             


Pro Gly  Asn Asp Ala Glu Met  Ser Lys His Pro Gly  Leu Val Leu 
    2000                 2005                 2010             


Ile Leu  Gly Lys Leu Ile Leu  Leu His His Glu His  Pro Glu Arg 
    2015                 2020                 2025             


Lys Arg  Ala Pro Gln Xaa Tyr  Glu Lys Glu Glu Asp  Glu Asp Lys 
    2030                 2035                 2040             


Gly Val  Ala Cys Ser Lys Asp  Glu Trp Trp Trp Asp  Cys Leu Glu 
    2045                 2050                 2055             


Val Leu  Arg Asp Asn Xaa Leu  Val Xaa Leu Ala Asn  Ile Ser Gly 
    2060                 2065                 2070             


Gln Leu  Asp Leu Ser Ala Tyr  Xaa Glu Ser Ile Cys  Leu Pro Ile 
    2075                 2080                 2085             


Leu Asp  Gly Leu Leu His Trp  Met Val Cys Pro Ser  Ala Glu Ala 
    2090                 2095                 2100             


Gln Asp  Pro Phe Pro Xaa Val  Gly Pro Asn Ser Val  Leu Ser Pro 
    2105                 2110                 2115             


Gln Arg  Leu Val Leu Glu Xaa  Leu Cys Lys Leu Ser  Ile Gln Asp 
    2120                 2125                 2130             


Asn Asn  Val Asp Leu Ile Leu  Ala Xaa Pro Pro Phe  Ser Arg Gln 
    2135                 2140                 2145             


Glu Lys  Phe Tyr Ala Xaa Leu  Val Arg Tyr Val Gly  Asp Arg Lys 
    2150                 2155                 2160             


Asn Pro  Val Cys Arg Glu Met  Ser Met Ala Leu Leu  Ser Asn Leu 
    2165                 2170                 2175             


Ala Gln  Gly Asp Ala Leu Ala  Ala Arg Ala Ile Ala  Val Gln Lys 
    2180                 2185                 2190             


Gly Ser  Ile Gly Asn Leu Ile  Ser Phe Leu Glu Asp  Gly Val Xaa 
    2195                 2200                 2205             


Met Ala  Gln Tyr Gln Gln Ser  Gln His Asn Leu Met  His Met Gln 
    2210                 2215                 2220             


Pro Pro  Pro Leu Glu Pro Pro  Ser Val Asp Met Met  Cys Arg Ala 
    2225                 2230                 2235             


Ala Lys  Ala Leu Leu Ala Met  Ala Arg Val Asp Glu  Asn Arg Ser 
    2240                 2245                 2250             


Glu Phe  Leu Leu His Glu Gly  Arg Leu Leu Asp Ile  Ser Ile Ser 
    2255                 2260                 2265             


Ala Val  Leu Asn Ser Leu Val  Ala Ser Val Ile Cys  Asp Val Leu 
    2270                 2275                 2280             


Phe Gln  Ile Gly Gln Leu 
    2285                 


<210> 3109
<211> 97
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<400> 3109
Met Pro Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser Ser Ser His Pro 
1               5                   10                  15      


Ala Leu Ser Gln Ser Pro Met Pro Gln Glu Arg Gly Phe Met Ala Gly 
            20                  25                  30          


Xaa Gln Arg Asn Pro Gln Met Ala Gln Tyr Gly Pro Gln Gln Xaa Gly 
        35                  40                  45              


Pro Ser Met Ser Pro His Pro Ser Pro Gly Gly Gln Met His Ala Gly 
    50                  55                  60                  


Ile Ser Ser Phe Gln Gln Ser Asn Ser Ser Gly Xaa Tyr Gly Pro Gln 
65                  70                  75                  80  


Met Ser Gln Tyr Gly Pro Gln Glu Glu Glu Xaa Glu Leu Trp Ser Asn 
                85                  90                  95      


Xaa 
    


<210> 3110
<211> 1486
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1278)..(1278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1306)..(1306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1322)..(1322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1339)..(1339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1405)..(1405)
<223> Selenocysteine

<400> 3110
Met Pro Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser Ser Ser His Pro 
1               5                   10                  15      


Ala Leu Ser Gln Ser Pro Met Pro Gln Glu Arg Gly Phe Met Ala Gly 
            20                  25                  30          


Xaa Gln Arg Asn Pro Gln Met Ala Gln Tyr Gly Pro Gln Gln Xaa Gly 
        35                  40                  45              


Pro Ser Met Ser Pro His Pro Ser Pro Gly Gly Gln Met His Ala Gly 
    50                  55                  60                  


Ile Ser Ser Phe Gln Gln Ser Asn Ser Ser Gly Xaa Tyr Gly Pro Gln 
65                  70                  75                  80  


Met Ser Gln Tyr Gly Pro Gln Gly Asn Tyr Ser Arg Pro Pro Ala Tyr 
                85                  90                  95      


Ser Gly Val Pro Ser Ala Ser Tyr Ser Gly Pro Gly Pro Gly Met Gly 
            100                 105                 110         


Ile Ser Ala Asn Asn Gln Met His Gly Gln Gly Pro Ser Gln Pro Cys 
        115                 120                 125             


Gly Ala Val Pro Leu Gly Arg Met Pro Ser Ala Gly Met Gln Asn Arg 
    130                 135                 140                 


Pro Phe Pro Gly Asn Met Ser Ser Met Xaa Pro Ser Ser Pro Gly Met 
145                 150                 155                 160 


Ser Gln Gln Gly Gly Pro Gly Met Gly Pro Pro Met Pro Xaa Val Asn 
                165                 170                 175     


Arg Lys Ala Gln Glu Ala Ala Ala Ala Val Met Gln Ala Ala Ala Asn 
            180                 185                 190         


Ser Ala Gln Ser Arg Gln Gly Ser Phe Pro Gly Met Asn Gln Ser Gly 
        195                 200                 205             


Leu Met Ala Ser Ser Ser Pro Tyr Ser Gln Pro Met Asn Asn Ser Ser 
    210                 215                 220                 


Ser Leu Met Asn Xaa Gln Ala Pro Pro Tyr Ser Met Ala Pro Ala Met 
225                 230                 235                 240 


Val Asn Ser Ser Ala Ala Ser Val Gly Leu Ala Asp Met Met Ser Pro 
                245                 250                 255     


Gly Glu Ser Lys Leu Pro Leu Pro Leu Lys Ala Asp Gly Lys Glu Glu 
            260                 265                 270         


Gly Xaa Pro Gln Pro Glu Ser Lys Ser Lys Lys Ser Ser Ser Ser Xaa 
        275                 280                 285             


Xaa Xaa Gly Glu Lys Ile Xaa Lys Val Tyr Glu Leu Gly Asn Glu Pro 
    290                 295                 300                 


Glu Arg Lys Leu Trp Val Asp Arg Tyr Leu Xaa Phe Met Glu Glu Arg 
305                 310                 315                 320 


Gly Ser Pro Val Ser Ser Leu Pro Ala Val Gly Lys Lys Pro Leu Asp 
                325                 330                 335     


Leu Phe Arg Leu Tyr Val Cys Val Lys Glu Ile Gly Gly Leu Ala Gln 
            340                 345                 350         


Val Asn Lys Asn Lys Lys Trp Arg Glu Leu Ala Xaa Asn Leu Asn Val 
        355                 360                 365             


Gly Xaa Ser Ser Ser Ala Ala Ser Ser Leu Lys Lys Gln Tyr Ile Gln 
    370                 375                 380                 


Tyr Leu Phe Ala Phe Glu Cys Lys Ile Glu Arg Gly Glu Glu Pro Pro 
385                 390                 395                 400 


Pro Glu Val Phe Ser Xaa Gly Asp Xaa Lys Lys Gln Pro Lys Leu Gln 
                405                 410                 415     


Pro Pro Ser Pro Ala Asn Ser Gly Ser Leu Gln Gly Pro Gln Xaa Pro 
            420                 425                 430         


Gln Ser Xaa Gly Ser Asn Ser Met Ala Glu Val Pro Gly Asp Leu Lys 
        435                 440                 445             


Pro Pro Xaa Pro Ala Ser Xaa Pro His Gly Gln Met Xaa Pro Met Gln 
    450                 455                 460                 


Gly Gly Arg Ser Ser Xaa Ile Ser Val His Asp Pro Phe Ser Asp Val 
465                 470                 475                 480 


Ser Asp Ser Ser Phe Pro Lys Arg Asn Ser Met Xaa Pro Asn Ala Pro 
                485                 490                 495     


Tyr Gln Gln Gly Met Ser Met Pro Asp Val Met Gly Arg Met Pro Tyr 
            500                 505                 510         


Glu Pro Asn Lys Asp Pro Phe Gly Gly Met Arg Lys Val Pro Gly Ser 
        515                 520                 525             


Ser Glu Pro Phe Met Xaa Gln Gly Gln Met Pro Asn Ser Ser Met Gln 
    530                 535                 540                 


Asp Met Tyr Asn Gln Ser Pro Ser Gly Ala Met Ser Asn Leu Gly Met 
545                 550                 555                 560 


Gly Gln Arg Gln Gln Phe Pro Tyr Gly Ala Ser Tyr Asp Arg Arg His 
                565                 570                 575     


Glu Pro Tyr Gly Gln Gln Tyr Pro Gly Gln Gly Pro Pro Ser Gly Gln 
            580                 585                 590         


Pro Pro Tyr Gly Gly His Gln Pro Gly Leu Tyr Pro Gln Gln Pro Asn 
        595                 600                 605             


Tyr Lys Arg His Met Asp Gly Met Tyr Gly Pro Pro Ala Lys Arg His 
    610                 615                 620                 


Glu Gly Asp Met Tyr Asn Met Gln Tyr Ser Ser Gln Gln Gln Glu Met 
625                 630                 635                 640 


Tyr Asn Gln Tyr Gly Gly Ser Tyr Ser Gly Pro Asp Arg Arg Pro Ile 
                645                 650                 655     


Gln Gly Gln Tyr Pro Tyr Pro Tyr Ser Arg Glu Arg Met Gln Gly Pro 
            660                 665                 670         


Gly Gln Ile Gln Xaa His Gly Ile Pro Pro Gln Met Met Gly Gly Pro 
        675                 680                 685             


Leu Gln Ser Ser Ser Ser Glu Gly Pro Gln Gln Asn Met Trp Ala Ala 
    690                 695                 700                 


Arg Asn Asp Met Pro Tyr Pro Tyr Gln Asn Arg Gln Gly Pro Gly Gly 
705                 710                 715                 720 


Pro Xaa Gln Ala Pro Pro Tyr Pro Gly Met Asn Arg Xaa Asp Asp Met 
                725                 730                 735     


Met Val Pro Asp Gln Arg Ile Asn His Glu Ser Gln Trp Pro Ser His 
            740                 745                 750         


Val Ser Gln Arg Gln Pro Tyr Met Ser Ser Ser Ala Ser Met Gln Pro 
        755                 760                 765             


Ile Xaa Arg Pro Pro Gln Pro Ser Tyr Gln Xaa Pro Pro Ser Leu Pro 
    770                 775                 780                 


Asn His Ile Ser Arg Ala Pro Ser Pro Ala Ser Phe Gln Arg Ser Leu 
785                 790                 795                 800 


Glu Asn Arg Met Ser Pro Ser Lys Ser Pro Phe Leu Pro Ser Met Lys 
                805                 810                 815     


Met Gln Lys Val Met Pro Xaa Val Pro Xaa Ser Gln Val Xaa Gly Pro 
            820                 825                 830         


Pro Pro Gln Pro Pro Pro Ile Arg Arg Glu Ile Xaa Phe Pro Pro Gly 
        835                 840                 845             


Ser Val Glu Ala Ser Gln Pro Val Leu Lys Gln Arg Arg Lys Ile Xaa 
    850                 855                 860                 


Ser Lys Asp Ile Val Xaa Pro Glu Ala Trp Arg Val Met Met Ser Leu 
865                 870                 875                 880 


Lys Ser Gly Leu Leu Ala Glu Ser Xaa Trp Ala Leu Asp Xaa Ile Asn 
                885                 890                 895     


Ile Leu Leu Tyr Asp Asp Ser Xaa Val Ala Xaa Phe Asn Leu Ser Gln 
            900                 905                 910         


Leu Ser Gly Phe Leu Glu Leu Leu Val Glu Tyr Phe Arg Lys Cys Leu 
        915                 920                 925             


Ile Asp Ile Phe Gly Ile Leu Met Glu Tyr Glu Val Gly Asp Pro Ser 
    930                 935                 940                 


Gln Lys Ala Leu Asp His Asn Ala Ala Arg Lys Asp Asp Ser Gln Ser 
945                 950                 955                 960 


Leu Ala Asp Asp Ser Gly Lys Glu Glu Glu Asp Ala Glu Cys Ile Asp 
                965                 970                 975     


Asp Asp Glu Glu Asp Glu Glu Asp Glu Glu Glu Asp Ser Glu Lys Xaa 
            980                 985                 990         


Glu Ser Asp Glu Lys Ser Ser Ile  Ala Leu Xaa Ala Pro  Asp Ala Ala 
        995                 1000                 1005             


Ala Asp  Pro Lys Glu Lys Pro  Lys Gln Ala Ser Lys  Phe Asp Lys 
    1010                 1015                 1020             


Leu Pro  Ile Lys Ile Val Lys  Lys Asn Asn Leu Phe  Val Val Asp 
    1025                 1030                 1035             


Arg Ser  Asp Lys Leu Gly Arg  Val Gln Glu Phe Asn  Ser Gly Leu 
    1040                 1045                 1050             


Leu His  Trp Gln Leu Gly Gly  Gly Asp Xaa Xaa Glu  His Ile Gln 
    1055                 1060                 1065             


Xaa His  Phe Glu Ser Lys Met  Glu Ile Pro Pro Arg  Arg Arg Pro 
    1070                 1075                 1080             


Pro Pro  Pro Leu Ser Ser Ala  Gly Arg Lys Lys Glu  Gln Glu Gly 
    1085                 1090                 1095             


Lys Gly  Asp Ser Glu Glu Gln  Gln Glu Lys Ser Ile  Ile Ala Xaa 
    1100                 1105                 1110             


Ile Asp  Asp Val Leu Ser Ala  Arg Pro Gly Ala Leu  Pro Glu Asp 
    1115                 1120                 1125             


Ala Asn  Pro Gly Pro Gln Xaa  Glu Ser Ser Lys Phe  Pro Phe Gly 
    1130                 1135                 1140             


Ile Gln  Gln Ala Lys Ser His  Arg Asn Ile Lys Leu  Leu Glu Asp 
    1145                 1150                 1155             


Glu Pro  Arg Ser Arg Asp Glu  Xaa Pro Leu Cys Xaa  Ile Ala His 
    1160                 1165                 1170             


Trp Gln  Asp Ser Leu Ala Lys  Arg Cys Ile Cys Val  Ser Asn Ile 
    1175                 1180                 1185             


Val Arg  Ser Leu Ser Phe Val  Pro Gly Asn Asp Ala  Glu Met Ser 
    1190                 1195                 1200             


Lys His  Pro Gly Leu Val Leu  Ile Leu Gly Lys Leu  Ile Leu Leu 
    1205                 1210                 1215             


His His  Glu His Pro Glu Arg  Lys Arg Ala Pro Gln  Xaa Tyr Glu 
    1220                 1225                 1230             


Lys Glu  Glu Asp Glu Asp Lys  Gly Val Ala Cys Ser  Lys Asp Glu 
    1235                 1240                 1245             


Trp Trp  Trp Asp Cys Leu Glu  Val Leu Arg Asp Asn  Xaa Leu Val 
    1250                 1255                 1260             


Xaa Leu  Ala Asn Ile Ser Gly  Gln Leu Asp Leu Ser  Ala Tyr Xaa 
    1265                 1270                 1275             


Glu Ser  Ile Cys Leu Pro Ile  Leu Asp Gly Leu Leu  His Trp Met 
    1280                 1285                 1290             


Val Cys  Pro Ser Ala Glu Ala  Gln Asp Pro Phe Pro  Xaa Val Gly 
    1295                 1300                 1305             


Pro Asn  Ser Val Leu Ser Pro  Gln Arg Leu Val Leu  Glu Xaa Leu 
    1310                 1315                 1320             


Cys Lys  Leu Ser Ile Gln Asp  Asn Asn Val Asp Leu  Ile Leu Ala 
    1325                 1330                 1335             


Xaa Pro  Pro Phe Ser Arg Gln  Glu Lys Phe Tyr Ala  Xaa Leu Val 
    1340                 1345                 1350             


Arg Tyr  Val Gly Asp Arg Lys  Asn Pro Val Cys Arg  Glu Met Ser 
    1355                 1360                 1365             


Met Ala  Leu Leu Ser Asn Leu  Ala Gln Gly Asp Ala  Leu Ala Ala 
    1370                 1375                 1380             


Arg Ala  Ile Ala Val Gln Lys  Gly Ser Ile Gly Asn  Leu Ile Ser 
    1385                 1390                 1395             


Phe Leu  Glu Asp Gly Val Xaa  Met Ala Gln Tyr Gln  Gln Ser Gln 
    1400                 1405                 1410             


His Asn  Leu Met His Met Gln  Pro Pro Pro Leu Glu  Pro Pro Ser 
    1415                 1420                 1425             


Val Asp  Met Met Cys Arg Ala  Ala Lys Ala Leu Leu  Ala Met Ala 
    1430                 1435                 1440             


Arg Val  Asp Glu Asn Arg Ser  Glu Phe Leu Leu His  Glu Gly Arg 
    1445                 1450                 1455             


Leu Leu  Asp Ile Ser Ile Ser  Ala Val Leu Asn Ser  Leu Val Ala 
    1460                 1465                 1470             


Ser Val  Ile Cys Asp Val Leu  Phe Gln Ile Gly Gln  Leu 
    1475                 1480                 1485     


<210> 3111
<211> 1539
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1314)..(1314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1317)..(1317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1359)..(1359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1375)..(1375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1392)..(1392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<400> 3111
Met Pro Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser Ser Ser His Pro 
1               5                   10                  15      


Ala Leu Ser Gln Ser Pro Met Pro Gln Glu Arg Gly Phe Met Ala Gly 
            20                  25                  30          


Xaa Gln Arg Asn Pro Gln Met Ala Gln Tyr Gly Pro Gln Gln Xaa Gly 
        35                  40                  45              


Pro Ser Met Ser Pro His Pro Ser Pro Gly Gly Gln Met His Ala Gly 
    50                  55                  60                  


Ile Ser Ser Phe Gln Gln Ser Asn Ser Ser Gly Xaa Tyr Gly Pro Gln 
65                  70                  75                  80  


Met Ser Gln Tyr Gly Pro Gln Gly Asn Tyr Ser Arg Pro Pro Ala Tyr 
                85                  90                  95      


Ser Gly Val Pro Ser Ala Ser Tyr Ser Gly Pro Gly Pro Gly Met Gly 
            100                 105                 110         


Ile Ser Ala Asn Asn Gln Met His Gly Gln Gly Pro Ser Gln Pro Cys 
        115                 120                 125             


Gly Ala Val Pro Leu Gly Arg Met Pro Ser Ala Gly Met Gln Asn Arg 
    130                 135                 140                 


Pro Phe Pro Gly Asn Met Ser Ser Met Xaa Pro Ser Ser Pro Gly Met 
145                 150                 155                 160 


Ser Gln Gln Gly Gly Pro Gly Met Gly Pro Pro Met Pro Xaa Val Asn 
                165                 170                 175     


Arg Lys Ala Gln Glu Ala Ala Ala Ala Val Met Gln Ala Ala Ala Asn 
            180                 185                 190         


Ser Ala Gln Ser Arg Gln Gly Ser Phe Pro Gly Met Asn Gln Ser Gly 
        195                 200                 205             


Leu Met Ala Ser Ser Ser Pro Tyr Ser Gln Pro Met Asn Asn Ser Ser 
    210                 215                 220                 


Ser Leu Met Asn Xaa Gln Ala Pro Pro Tyr Ser Met Ala Pro Ala Met 
225                 230                 235                 240 


Val Asn Ser Ser Ala Ala Ser Val Gly Leu Ala Asp Met Met Ser Pro 
                245                 250                 255     


Gly Glu Ser Lys Leu Pro Leu Pro Leu Lys Ala Asp Gly Lys Glu Glu 
            260                 265                 270         


Gly Xaa Pro Gln Pro Glu Ser Lys Ser Lys Asp Ser Tyr Ser Ser Gln 
        275                 280                 285             


Gly Ile Ser Gln Pro Pro Xaa Pro Gly Asn Leu Pro Val Pro Ser Pro 
    290                 295                 300                 


Met Ser Pro Ser Ser Ala Ser Ile Ser Ser Phe His Gly Asp Glu Ser 
305                 310                 315                 320 


Asp Ser Ile Ser Ser Pro Gly Trp Pro Lys Xaa Pro Ser Ser Pro Lys 
                325                 330                 335     


Ser Ser Ser Ser Xaa Xaa Xaa Gly Glu Lys Ile Xaa Lys Val Tyr Glu 
            340                 345                 350         


Leu Gly Asn Glu Pro Glu Arg Lys Leu Trp Val Asp Arg Tyr Leu Xaa 
        355                 360                 365             


Phe Met Glu Glu Arg Gly Ser Pro Val Ser Ser Leu Pro Ala Val Gly 
    370                 375                 380                 


Lys Lys Pro Leu Asp Leu Phe Arg Leu Tyr Val Cys Val Lys Glu Ile 
385                 390                 395                 400 


Gly Gly Leu Ala Gln Val Asn Lys Asn Lys Lys Trp Arg Glu Leu Ala 
                405                 410                 415     


Xaa Asn Leu Asn Val Gly Xaa Ser Ser Ser Ala Ala Ser Ser Leu Lys 
            420                 425                 430         


Lys Gln Tyr Ile Gln Tyr Leu Phe Ala Phe Glu Cys Lys Ile Glu Arg 
        435                 440                 445             


Gly Glu Glu Pro Pro Pro Glu Val Phe Ser Xaa Gly Asp Xaa Lys Lys 
    450                 455                 460                 


Gln Pro Lys Leu Gln Pro Pro Ser Pro Ala Asn Ser Gly Ser Leu Gln 
465                 470                 475                 480 


Gly Pro Gln Xaa Pro Gln Ser Xaa Gly Ser Asn Ser Met Ala Glu Val 
                485                 490                 495     


Pro Gly Asp Leu Lys Pro Pro Xaa Pro Ala Ser Xaa Pro His Gly Gln 
            500                 505                 510         


Met Xaa Pro Met Gln Gly Gly Arg Ser Ser Xaa Ile Ser Val His Asp 
        515                 520                 525             


Pro Phe Ser Asp Val Ser Asp Ser Ser Phe Pro Lys Arg Asn Ser Met 
    530                 535                 540                 


Xaa Pro Asn Ala Pro Tyr Gln Gln Gly Met Ser Met Pro Asp Val Met 
545                 550                 555                 560 


Gly Arg Met Pro Tyr Glu Pro Asn Lys Asp Pro Phe Gly Gly Met Arg 
                565                 570                 575     


Lys Val Pro Gly Ser Ser Glu Pro Phe Met Xaa Gln Gly Gln Met Pro 
            580                 585                 590         


Asn Ser Ser Met Gln Asp Met Tyr Asn Gln Ser Pro Ser Gly Ala Met 
        595                 600                 605             


Ser Asn Leu Gly Met Gly Gln Arg Gln Gln Phe Pro Tyr Gly Ala Ser 
    610                 615                 620                 


Tyr Asp Arg Arg His Glu Pro Tyr Gly Gln Gln Tyr Pro Gly Gln Gly 
625                 630                 635                 640 


Pro Pro Ser Gly Gln Pro Pro Tyr Gly Gly His Gln Pro Gly Leu Tyr 
                645                 650                 655     


Pro Gln Gln Pro Asn Tyr Lys Arg His Met Asp Gly Met Tyr Gly Pro 
            660                 665                 670         


Pro Ala Lys Arg His Glu Gly Asp Met Tyr Asn Met Gln Tyr Ser Ser 
        675                 680                 685             


Gln Gln Gln Glu Met Tyr Asn Gln Tyr Gly Gly Ser Tyr Ser Gly Pro 
    690                 695                 700                 


Asp Arg Arg Pro Ile Gln Gly Gln Tyr Pro Tyr Pro Tyr Ser Arg Glu 
705                 710                 715                 720 


Arg Met Gln Gly Pro Gly Gln Ile Gln Xaa His Gly Ile Pro Pro Gln 
                725                 730                 735     


Met Met Gly Gly Pro Leu Gln Ser Ser Ser Ser Glu Gly Pro Gln Gln 
            740                 745                 750         


Asn Met Trp Ala Ala Arg Asn Asp Met Pro Tyr Pro Tyr Gln Asn Arg 
        755                 760                 765             


Gln Gly Pro Gly Gly Pro Xaa Gln Ala Pro Pro Tyr Pro Gly Met Asn 
    770                 775                 780                 


Arg Xaa Asp Asp Met Met Val Pro Asp Gln Arg Ile Asn His Glu Ser 
785                 790                 795                 800 


Gln Trp Pro Ser His Val Ser Gln Arg Gln Pro Tyr Met Ser Ser Ser 
                805                 810                 815     


Ala Ser Met Gln Pro Ile Xaa Arg Pro Pro Gln Pro Ser Tyr Gln Xaa 
            820                 825                 830         


Pro Pro Ser Leu Pro Asn His Ile Ser Arg Ala Pro Ser Pro Ala Ser 
        835                 840                 845             


Phe Gln Arg Ser Leu Glu Asn Arg Met Ser Pro Ser Lys Ser Pro Phe 
    850                 855                 860                 


Leu Pro Ser Met Lys Met Gln Lys Val Met Pro Xaa Val Pro Xaa Ser 
865                 870                 875                 880 


Gln Val Xaa Gly Pro Pro Pro Gln Pro Pro Pro Ile Arg Arg Glu Ile 
                885                 890                 895     


Xaa Phe Pro Pro Gly Ser Val Glu Ala Ser Gln Pro Val Leu Lys Gln 
            900                 905                 910         


Arg Arg Lys Ile Xaa Ser Lys Asp Ile Val Xaa Pro Glu Ala Trp Arg 
        915                 920                 925             


Val Met Met Ser Leu Lys Ser Gly Leu Leu Ala Glu Ser Xaa Trp Ala 
    930                 935                 940                 


Leu Asp Xaa Ile Asn Ile Leu Leu Tyr Asp Asp Ser Xaa Val Ala Xaa 
945                 950                 955                 960 


Phe Asn Leu Ser Gln Leu Ser Gly Phe Leu Glu Leu Leu Val Glu Tyr 
                965                 970                 975     


Phe Arg Lys Cys Leu Ile Asp Ile Phe Gly Ile Leu Met Glu Tyr Glu 
            980                 985                 990         


Val Gly Asp Pro Ser Gln Lys Ala  Leu Asp His Asn Ala  Ala Arg Lys 
        995                 1000                 1005             


Asp Asp  Ser Gln Ser Leu Ala  Asp Asp Ser Gly Lys  Glu Glu Glu 
    1010                 1015                 1020             


Asp Ala  Glu Cys Ile Asp Asp  Asp Glu Glu Asp Glu  Glu Asp Glu 
    1025                 1030                 1035             


Glu Glu  Asp Ser Glu Lys Xaa  Glu Ser Asp Glu Lys  Ser Ser Ile 
    1040                 1045                 1050             


Ala Leu  Xaa Ala Pro Asp Ala  Ala Ala Asp Pro Lys  Glu Lys Pro 
    1055                 1060                 1065             


Lys Gln  Ala Ser Lys Phe Asp  Lys Leu Pro Ile Lys  Ile Val Lys 
    1070                 1075                 1080             


Lys Asn  Asn Leu Phe Val Val  Asp Arg Ser Asp Lys  Leu Gly Arg 
    1085                 1090                 1095             


Val Gln  Glu Phe Asn Ser Gly  Leu Leu His Trp Gln  Leu Gly Gly 
    1100                 1105                 1110             


Gly Asp  Xaa Xaa Glu His Ile  Gln Xaa His Phe Glu  Ser Lys Met 
    1115                 1120                 1125             


Glu Ile  Pro Pro Arg Arg Arg  Pro Pro Pro Pro Leu  Ser Ser Ala 
    1130                 1135                 1140             


Gly Arg  Lys Lys Glu Gln Glu  Gly Lys Gly Asp Ser  Glu Glu Gln 
    1145                 1150                 1155             


Gln Glu  Lys Ser Ile Ile Ala  Xaa Ile Asp Asp Val  Leu Ser Ala 
    1160                 1165                 1170             


Arg Pro  Gly Ala Leu Pro Glu  Asp Ala Asn Pro Gly  Pro Gln Xaa 
    1175                 1180                 1185             


Glu Ser  Ser Lys Phe Pro Phe  Gly Ile Gln Gln Ala  Lys Ser His 
    1190                 1195                 1200             


Arg Asn  Ile Lys Leu Leu Glu  Asp Glu Pro Arg Ser  Arg Asp Glu 
    1205                 1210                 1215             


Xaa Pro  Leu Cys Xaa Ile Ala  His Trp Gln Asp Ser  Leu Ala Lys 
    1220                 1225                 1230             


Arg Cys  Ile Cys Val Ser Asn  Ile Val Arg Ser Leu  Ser Phe Val 
    1235                 1240                 1245             


Pro Gly  Asn Asp Ala Glu Met  Ser Lys His Pro Gly  Leu Val Leu 
    1250                 1255                 1260             


Ile Leu  Gly Lys Leu Ile Leu  Leu His His Glu His  Pro Glu Arg 
    1265                 1270                 1275             


Lys Arg  Ala Pro Gln Xaa Tyr  Glu Lys Glu Glu Asp  Glu Asp Lys 
    1280                 1285                 1290             


Gly Val  Ala Cys Ser Lys Asp  Glu Trp Trp Trp Asp  Cys Leu Glu 
    1295                 1300                 1305             


Val Leu  Arg Asp Asn Xaa Leu  Val Xaa Leu Ala Asn  Ile Ser Gly 
    1310                 1315                 1320             


Gln Leu  Asp Leu Ser Ala Tyr  Xaa Glu Ser Ile Cys  Leu Pro Ile 
    1325                 1330                 1335             


Leu Asp  Gly Leu Leu His Trp  Met Val Cys Pro Ser  Ala Glu Ala 
    1340                 1345                 1350             


Gln Asp  Pro Phe Pro Xaa Val  Gly Pro Asn Ser Val  Leu Ser Pro 
    1355                 1360                 1365             


Gln Arg  Leu Val Leu Glu Xaa  Leu Cys Lys Leu Ser  Ile Gln Asp 
    1370                 1375                 1380             


Asn Asn  Val Asp Leu Ile Leu  Ala Xaa Pro Pro Phe  Ser Arg Gln 
    1385                 1390                 1395             


Glu Lys  Phe Tyr Ala Xaa Leu  Val Arg Tyr Val Gly  Asp Arg Lys 
    1400                 1405                 1410             


Asn Pro  Val Cys Arg Glu Met  Ser Met Ala Leu Leu  Ser Asn Leu 
    1415                 1420                 1425             


Ala Gln  Gly Asp Ala Leu Ala  Ala Arg Ala Ile Ala  Val Gln Lys 
    1430                 1435                 1440             


Gly Ser  Ile Gly Asn Leu Ile  Ser Phe Leu Glu Asp  Gly Val Xaa 
    1445                 1450                 1455             


Met Ala  Gln Tyr Gln Gln Ser  Gln His Asn Leu Met  His Met Gln 
    1460                 1465                 1470             


Pro Pro  Pro Leu Glu Pro Pro  Ser Val Asp Met Met  Cys Arg Ala 
    1475                 1480                 1485             


Ala Lys  Ala Leu Leu Ala Met  Ala Arg Val Asp Glu  Asn Arg Ser 
    1490                 1495                 1500             


Glu Phe  Leu Leu His Glu Gly  Arg Leu Leu Asp Ile  Ser Ile Ser 
    1505                 1510                 1515             


Ala Val  Leu Asn Ser Leu Val  Ala Ser Val Ile Cys  Asp Val Leu 
    1520                 1525                 1530             


Phe Gln  Ile Gly Gln Leu 
    1535                 


<210> 3112
<211> 1479
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (996)..(996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1106)..(1106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1128)..(1128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1224)..(1224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1299)..(1299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1315)..(1315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1344)..(1344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1398)..(1398)
<223> Selenocysteine

<400> 3112
Met Pro Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser Ser Ser His Pro 
1               5                   10                  15      


Ala Leu Ser Gln Ser Pro Met Pro Gln Glu Arg Gly Asn Tyr Ser Arg 
            20                  25                  30          


Pro Pro Ala Tyr Ser Gly Val Pro Ser Ala Ser Tyr Ser Gly Pro Gly 
        35                  40                  45              


Pro Gly Met Gly Ile Ser Ala Asn Asn Gln Met His Gly Gln Gly Pro 
    50                  55                  60                  


Ser Gln Pro Cys Gly Ala Val Pro Leu Gly Arg Met Pro Ser Ala Gly 
65                  70                  75                  80  


Met Gln Asn Arg Pro Phe Pro Gly Asn Met Ser Ser Met Xaa Pro Ser 
                85                  90                  95      


Ser Pro Gly Met Ser Gln Gln Gly Gly Pro Gly Met Gly Pro Pro Met 
            100                 105                 110         


Pro Xaa Val Asn Arg Lys Ala Gln Glu Ala Ala Ala Ala Val Met Gln 
        115                 120                 125             


Ala Ala Ala Asn Ser Ala Gln Ser Arg Gln Gly Ser Phe Pro Gly Met 
    130                 135                 140                 


Asn Gln Ser Gly Leu Met Ala Ser Ser Ser Pro Tyr Ser Gln Pro Met 
145                 150                 155                 160 


Asn Asn Ser Ser Ser Leu Met Asn Xaa Gln Ala Pro Pro Tyr Ser Met 
                165                 170                 175     


Ala Pro Ala Met Val Asn Ser Ser Ala Ala Ser Val Gly Leu Ala Asp 
            180                 185                 190         


Met Met Ser Pro Gly Glu Ser Lys Leu Pro Leu Pro Leu Lys Ala Asp 
        195                 200                 205             


Gly Lys Glu Glu Gly Xaa Pro Gln Pro Glu Ser Lys Ser Lys Asp Ser 
    210                 215                 220                 


Tyr Ser Ser Gln Gly Ile Ser Gln Pro Pro Xaa Pro Gly Asn Leu Pro 
225                 230                 235                 240 


Val Pro Ser Pro Met Ser Pro Ser Ser Ala Ser Ile Ser Ser Phe His 
                245                 250                 255     


Gly Asp Glu Ser Asp Ser Ile Ser Ser Pro Gly Trp Pro Lys Xaa Pro 
            260                 265                 270         


Ser Ser Pro Lys Ser Ser Ser Ser Xaa Xaa Xaa Gly Glu Lys Ile Xaa 
        275                 280                 285             


Lys Val Tyr Glu Leu Gly Asn Glu Pro Glu Arg Lys Leu Trp Val Asp 
    290                 295                 300                 


Arg Tyr Leu Xaa Phe Met Glu Glu Arg Gly Ser Pro Val Ser Ser Leu 
305                 310                 315                 320 


Pro Ala Val Gly Lys Lys Pro Leu Asp Leu Phe Arg Leu Tyr Val Cys 
                325                 330                 335     


Val Lys Glu Ile Gly Gly Leu Ala Gln Val Asn Lys Asn Lys Lys Trp 
            340                 345                 350         


Arg Glu Leu Ala Xaa Asn Leu Asn Val Gly Xaa Ser Ser Ser Ala Ala 
        355                 360                 365             


Ser Ser Leu Lys Lys Gln Tyr Ile Gln Tyr Leu Phe Ala Phe Glu Cys 
    370                 375                 380                 


Lys Ile Glu Arg Gly Glu Glu Pro Pro Pro Glu Val Phe Ser Xaa Gly 
385                 390                 395                 400 


Asp Xaa Lys Lys Gln Pro Lys Leu Gln Pro Pro Ser Pro Ala Asn Ser 
                405                 410                 415     


Gly Ser Leu Gln Gly Pro Gln Xaa Pro Gln Ser Xaa Gly Ser Asn Ser 
            420                 425                 430         


Met Ala Glu Val Pro Gly Asp Leu Lys Pro Pro Xaa Pro Ala Ser Xaa 
        435                 440                 445             


Pro His Gly Gln Met Xaa Pro Met Gln Gly Gly Arg Ser Ser Xaa Ile 
    450                 455                 460                 


Ser Val His Asp Pro Phe Ser Asp Val Ser Asp Ser Ser Phe Pro Lys 
465                 470                 475                 480 


Arg Asn Ser Met Xaa Pro Asn Ala Pro Tyr Gln Gln Gly Met Ser Met 
                485                 490                 495     


Pro Asp Val Met Gly Arg Met Pro Tyr Glu Pro Asn Lys Asp Pro Phe 
            500                 505                 510         


Gly Gly Met Arg Lys Val Pro Gly Ser Ser Glu Pro Phe Met Xaa Gln 
        515                 520                 525             


Gly Gln Met Pro Asn Ser Ser Met Gln Asp Met Tyr Asn Gln Ser Pro 
    530                 535                 540                 


Ser Gly Ala Met Ser Asn Leu Gly Met Gly Gln Arg Gln Gln Phe Pro 
545                 550                 555                 560 


Tyr Gly Ala Ser Tyr Asp Arg Arg His Glu Pro Tyr Gly Gln Gln Tyr 
                565                 570                 575     


Pro Gly Gln Gly Pro Pro Ser Gly Gln Pro Pro Tyr Gly Gly His Gln 
            580                 585                 590         


Pro Gly Leu Tyr Pro Gln Gln Pro Asn Tyr Lys Arg His Met Asp Gly 
        595                 600                 605             


Met Tyr Gly Pro Pro Ala Lys Arg His Glu Gly Asp Met Tyr Asn Met 
    610                 615                 620                 


Gln Tyr Ser Ser Gln Gln Gln Glu Met Tyr Asn Gln Tyr Gly Gly Ser 
625                 630                 635                 640 


Tyr Ser Gly Pro Asp Arg Arg Pro Ile Gln Gly Gln Tyr Pro Tyr Pro 
                645                 650                 655     


Tyr Ser Arg Glu Arg Met Gln Gly Pro Gly Gln Ile Gln Xaa His Gly 
            660                 665                 670         


Ile Pro Pro Gln Met Met Gly Gly Pro Leu Gln Ser Ser Ser Ser Glu 
        675                 680                 685             


Gly Pro Gln Gln Asn Met Trp Ala Ala Arg Asn Asp Met Pro Tyr Pro 
    690                 695                 700                 


Tyr Gln Asn Arg Gln Gly Pro Gly Gly Pro Xaa Gln Ala Pro Pro Tyr 
705                 710                 715                 720 


Pro Gly Met Asn Arg Xaa Asp Asp Met Met Val Pro Asp Gln Arg Ile 
                725                 730                 735     


Asn His Glu Ser Gln Trp Pro Ser His Val Ser Gln Arg Gln Pro Tyr 
            740                 745                 750         


Met Ser Ser Ser Ala Ser Met Gln Pro Ile Xaa Arg Pro Pro Gln Pro 
        755                 760                 765             


Ser Tyr Gln Xaa Pro Pro Ser Leu Pro Asn His Ile Ser Arg Ala Pro 
    770                 775                 780                 


Ser Pro Ala Ser Phe Gln Arg Ser Leu Glu Asn Arg Met Ser Pro Ser 
785                 790                 795                 800 


Lys Ser Pro Phe Leu Pro Ser Met Lys Met Gln Lys Val Met Pro Xaa 
                805                 810                 815     


Val Pro Xaa Ser Gln Val Xaa Gly Pro Pro Pro Gln Pro Pro Pro Ile 
            820                 825                 830         


Arg Arg Glu Ile Xaa Phe Pro Pro Gly Ser Val Glu Ala Ser Gln Pro 
        835                 840                 845             


Val Leu Lys Gln Arg Arg Lys Ile Xaa Ser Lys Asp Ile Val Xaa Pro 
    850                 855                 860                 


Glu Ala Trp Arg Val Met Met Ser Leu Lys Ser Gly Leu Leu Ala Glu 
865                 870                 875                 880 


Ser Xaa Trp Ala Leu Asp Xaa Ile Asn Ile Leu Leu Tyr Asp Asp Ser 
                885                 890                 895     


Xaa Val Ala Xaa Phe Asn Leu Ser Gln Leu Ser Gly Phe Leu Glu Leu 
            900                 905                 910         


Leu Val Glu Tyr Phe Arg Lys Cys Leu Ile Asp Ile Phe Gly Ile Leu 
        915                 920                 925             


Met Glu Tyr Glu Val Gly Asp Pro Ser Gln Lys Ala Leu Asp His Asn 
    930                 935                 940                 


Ala Ala Arg Lys Asp Asp Ser Gln Ser Leu Ala Asp Asp Ser Gly Lys 
945                 950                 955                 960 


Glu Glu Glu Asp Ala Glu Cys Ile Asp Asp Asp Glu Glu Asp Glu Glu 
                965                 970                 975     


Asp Glu Glu Glu Asp Ser Glu Lys Xaa Glu Ser Asp Glu Lys Ser Ser 
            980                 985                 990         


Ile Ala Leu Xaa Ala Pro Asp Ala  Ala Ala Asp Pro Lys  Glu Lys Pro 
        995                 1000                 1005             


Lys Gln  Ala Ser Lys Phe Asp  Lys Leu Pro Ile Lys  Ile Val Lys 
    1010                 1015                 1020             


Lys Asn  Asn Leu Phe Val Val  Asp Arg Ser Asp Lys  Leu Gly Arg 
    1025                 1030                 1035             


Val Gln  Glu Phe Asn Ser Gly  Leu Leu His Trp Gln  Leu Gly Gly 
    1040                 1045                 1050             


Gly Asp  Xaa Xaa Glu His Ile  Gln Xaa His Phe Glu  Ser Lys Met 
    1055                 1060                 1065             


Glu Ile  Pro Pro Arg Arg Arg  Pro Pro Pro Pro Leu  Ser Ser Ala 
    1070                 1075                 1080             


Gly Arg  Lys Lys Glu Gln Glu  Gly Lys Gly Asp Ser  Glu Glu Gln 
    1085                 1090                 1095             


Gln Glu  Lys Ser Ile Ile Ala  Xaa Ile Asp Asp Val  Leu Ser Ala 
    1100                 1105                 1110             


Arg Pro  Gly Ala Leu Pro Glu  Asp Ala Asn Pro Gly  Pro Gln Xaa 
    1115                 1120                 1125             


Glu Ser  Ser Lys Phe Pro Phe  Gly Ile Gln Gln Ala  Lys Ser His 
    1130                 1135                 1140             


Arg Asn  Ile Lys Leu Leu Glu  Asp Glu Pro Arg Ser  Arg Asp Glu 
    1145                 1150                 1155             


Xaa Pro  Leu Cys Xaa Ile Ala  His Trp Gln Asp Ser  Leu Ala Lys 
    1160                 1165                 1170             


Arg Cys  Ile Cys Val Ser Asn  Ile Val Arg Ser Leu  Ser Phe Val 
    1175                 1180                 1185             


Pro Gly  Asn Asp Ala Glu Met  Ser Lys His Pro Gly  Leu Val Leu 
    1190                 1195                 1200             


Ile Leu  Gly Lys Leu Ile Leu  Leu His His Glu His  Pro Glu Arg 
    1205                 1210                 1215             


Lys Arg  Ala Pro Gln Xaa Tyr  Glu Lys Glu Glu Asp  Glu Asp Lys 
    1220                 1225                 1230             


Gly Val  Ala Cys Ser Lys Asp  Glu Trp Trp Trp Asp  Cys Leu Glu 
    1235                 1240                 1245             


Val Leu  Arg Asp Asn Xaa Leu  Val Xaa Leu Ala Asn  Ile Ser Gly 
    1250                 1255                 1260             


Gln Leu  Asp Leu Ser Ala Tyr  Xaa Glu Ser Ile Cys  Leu Pro Ile 
    1265                 1270                 1275             


Leu Asp  Gly Leu Leu His Trp  Met Val Cys Pro Ser  Ala Glu Ala 
    1280                 1285                 1290             


Gln Asp  Pro Phe Pro Xaa Val  Gly Pro Asn Ser Val  Leu Ser Pro 
    1295                 1300                 1305             


Gln Arg  Leu Val Leu Glu Xaa  Leu Cys Lys Leu Ser  Ile Gln Asp 
    1310                 1315                 1320             


Asn Asn  Val Asp Leu Ile Leu  Ala Xaa Pro Pro Phe  Ser Arg Gln 
    1325                 1330                 1335             


Glu Lys  Phe Tyr Ala Xaa Leu  Val Arg Tyr Val Gly  Asp Arg Lys 
    1340                 1345                 1350             


Asn Pro  Val Cys Arg Glu Met  Ser Met Ala Leu Leu  Ser Asn Leu 
    1355                 1360                 1365             


Ala Gln  Gly Asp Ala Leu Ala  Ala Arg Ala Ile Ala  Val Gln Lys 
    1370                 1375                 1380             


Gly Ser  Ile Gly Asn Leu Ile  Ser Phe Leu Glu Asp  Gly Val Xaa 
    1385                 1390                 1395             


Met Ala  Gln Tyr Gln Gln Ser  Gln His Asn Leu Met  His Met Gln 
    1400                 1405                 1410             


Pro Pro  Pro Leu Glu Pro Pro  Ser Val Asp Met Met  Cys Arg Ala 
    1415                 1420                 1425             


Ala Lys  Ala Leu Leu Ala Met  Ala Arg Val Asp Glu  Asn Arg Ser 
    1430                 1435                 1440             


Glu Phe  Leu Leu His Glu Gly  Arg Leu Leu Asp Ile  Ser Ile Ser 
    1445                 1450                 1455             


Ala Val  Leu Asn Ser Leu Val  Ala Ser Val Ile Cys  Asp Val Leu 
    1460                 1465                 1470             


Phe Gln  Ile Gly Gln Leu 
    1475                 


<210> 3113
<211> 727
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<400> 3113
Met Pro Pro Gln Tyr Gly Gln Gln Gly Val Ser Gly Tyr Cys Gln Gln 
1               5                   10                  15      


Gly Gln Gln Pro Tyr Tyr Ser Gln Gln Pro Gln Pro Pro His Leu Pro 
            20                  25                  30          


Pro Gln Ala Gln Tyr Leu Pro Ser Gln Ser Gln Gln Arg Tyr Gln Pro 
        35                  40                  45              


Gln Gln Asp Met Ser Gln Glu Gly Tyr Gly Xaa Arg Ser Gln Pro Pro 
    50                  55                  60                  


Leu Ala Pro Gly Lys Pro Asn His Glu Asp Leu Asn Leu Ile Gln Gln 
65                  70                  75                  80  


Glu Arg Pro Ser Ser Leu Pro Asp Leu Ser Gly Ser Ile Asp Asp Leu 
                85                  90                  95      


Pro Xaa Gly Xaa Glu Ala Xaa Leu Ser Ser Ala Val Ser Ala Ser Gly 
            100                 105                 110         


Ser Xaa Ser Ser Gln Gly Asp Gln Ser Asn Pro Ala Gln Ser Pro Phe 
        115                 120                 125             


Ser Pro His Ala Ser Pro His Leu Ser Ser Ile Pro Gly Gly Pro Ser 
    130                 135                 140                 


Pro Ser Pro Val Gly Ser Pro Val Gly Ser Asn Gln Ser Arg Ser Gly 
145                 150                 155                 160 


Pro Ile Ser Pro Ala Ser Ile Pro Gly Ser Gln Met Pro Pro Gln Pro 
                165                 170                 175     


Pro Gly Ser Gln Ser Glu Ser Ser Ser His Pro Ala Leu Ser Gln Ser 
            180                 185                 190         


Pro Met Pro Gln Glu Arg Gly Phe Met Ala Gly Xaa Gln Arg Asn Pro 
        195                 200                 205             


Gln Met Ala Gln Tyr Gly Pro Gln Gln Xaa Gly Pro Ser Met Ser Pro 
    210                 215                 220                 


His Pro Ser Pro Gly Gly Gln Met His Ala Gly Ile Ser Ser Phe Gln 
225                 230                 235                 240 


Gln Ser Asn Ser Ser Gly Xaa Tyr Gly Pro Gln Met Ser Gln Tyr Gly 
                245                 250                 255     


Pro Gln Gly Asn Tyr Ser Arg Pro Pro Ala Tyr Ser Gly Val Pro Ser 
            260                 265                 270         


Ala Ser Tyr Ser Gly Pro Gly Pro Gly Met Gly Ile Ser Ala Asn Asn 
        275                 280                 285             


Gln Met His Gly Gln Gly Pro Ser Gln Pro Cys Gly Ala Val Pro Leu 
    290                 295                 300                 


Gly Arg Met Pro Ser Ala Gly Met Gln Asn Arg Pro Phe Pro Gly Asn 
305                 310                 315                 320 


Met Ser Ser Met Xaa Pro Ser Ser Pro Gly Met Ser Gln Gln Gly Gly 
                325                 330                 335     


Pro Gly Met Gly Pro Pro Met Pro Xaa Val Asn Arg Lys Ala Gln Glu 
            340                 345                 350         


Ala Ala Ala Ala Val Met Gln Ala Ala Ala Asn Ser Ala Gln Ser Arg 
        355                 360                 365             


Gln Gly Ser Phe Pro Gly Met Asn Gln Ser Gly Leu Met Ala Ser Ser 
    370                 375                 380                 


Ser Pro Tyr Ser Gln Pro Met Asn Asn Ser Ser Ser Leu Met Asn Xaa 
385                 390                 395                 400 


Gln Ala Pro Pro Tyr Ser Met Ala Pro Ala Met Val Asn Ser Ser Ala 
                405                 410                 415     


Ala Ser Val Gly Leu Ala Asp Met Met Ser Pro Gly Glu Ser Lys Leu 
            420                 425                 430         


Pro Leu Pro Leu Lys Ala Asp Gly Lys Glu Glu Gly Xaa Pro Gln Pro 
        435                 440                 445             


Glu Ser Lys Ser Lys Asp Ser Tyr Ser Ser Gln Gly Ile Ser Gln Pro 
    450                 455                 460                 


Pro Xaa Pro Gly Asn Leu Pro Val Pro Ser Pro Met Ser Pro Ser Ser 
465                 470                 475                 480 


Ala Ser Ile Ser Ser Phe His Gly Asp Glu Ser Asp Ser Ile Ser Ser 
                485                 490                 495     


Pro Gly Trp Pro Lys Xaa Pro Ser Ser Pro Lys Ser Ser Ser Ser Xaa 
            500                 505                 510         


Xaa Xaa Gly Glu Lys Ile Xaa Lys Val Tyr Glu Leu Gly Asn Glu Pro 
        515                 520                 525             


Glu Arg Lys Leu Trp Val Asp Arg Tyr Leu Xaa Phe Met Glu Glu Arg 
    530                 535                 540                 


Gly Ser Pro Val Ser Ser Leu Pro Ala Val Gly Lys Lys Pro Leu Asp 
545                 550                 555                 560 


Leu Phe Arg Leu Tyr Val Cys Val Lys Glu Ile Gly Gly Leu Ala Gln 
                565                 570                 575     


Val Asn Lys Asn Lys Lys Trp Arg Glu Leu Ala Xaa Asn Leu Asn Val 
            580                 585                 590         


Gly Xaa Ser Ser Ser Ala Ala Ser Ser Leu Lys Lys Gln Tyr Ile Gln 
        595                 600                 605             


Tyr Leu Phe Ala Phe Glu Cys Lys Ile Glu Arg Gly Glu Glu Pro Pro 
    610                 615                 620                 


Pro Glu Val Phe Ser Xaa Gly Asp Xaa Lys Lys Gln Pro Lys Leu Gln 
625                 630                 635                 640 


Pro Pro Ser Pro Val Val Gln Met Glu Pro Arg Ala Cys Asp Xaa Gly 
                645                 650                 655     


Gly Ser Gly Arg Lys Ala Ser Trp Ser Arg Pro Ala Pro Arg Ala Arg 
            660                 665                 670         


Ala Gly Gly Ser Arg His Xaa Gln Ala Ser Gly Gly Arg Arg Gln Arg 
        675                 680                 685             


His Pro Gly Leu Gln Lys Pro Leu Asp Ser Leu Pro Pro Xaa Gln Gln 
    690                 695                 700                 


Val Ala Ser Pro Ile Pro Val Pro Ser Leu Gly Lys Val Ser Gly Asn 
705                 710                 715                 720 


Ile Phe Val Val Lys Gly Lys 
                725         


<210> 3114
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<400> 3114
Pro Gln Gln Gln Met Pro Pro Gln Tyr Gly Gln Gln Gly Val Ser Gly 
1               5                   10                  15      


Tyr Cys Gln Gln Gly Gln Gln Pro Tyr Tyr Ser Gln Gln Pro Gln Pro 
            20                  25                  30          


Pro His Leu Pro Pro Gln Ala Gln Tyr Leu Pro Ser Gln Ser Gln Gln 
        35                  40                  45              


Arg Tyr Gln Pro Gln Gln Asp Met Ser Gln Glu Gly Tyr Gly Xaa Arg 
    50                  55                  60                  


Ser Gln Pro Pro Leu Ala Pro Gly Lys Pro Asn His Glu Asp Leu Asn 
65                  70                  75                  80  


Leu Ile Gln Gln Glu Arg Pro Ser Ser Leu Pro Arg Xaa 
                85                  90              


<210> 3115
<211> 84
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<400> 3115
Ser His Pro Ala Met Ser Pro Gly Xaa Pro Gly Pro Xaa Met Gly Arg 
1               5                   10                  15      


Ser Gln Gly Ser Pro Met Asp Pro Met Val Met Lys Arg Pro Gln Leu 
            20                  25                  30          


Tyr Gly Met Gly Ser Asn Pro His Ser Gln Pro Gln Gln Ser Ser Pro 
        35                  40                  45              


Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly Pro Gln Arg Tyr Pro Ile 
    50                  55                  60                  


Gly Ile Gln Gly Arg Xaa Pro Gly Ala Met Ala Gly Met Gln Tyr Pro 
65                  70                  75                  80  


Gln Gln Gln Phe 
                


<210> 3116
<211> 1758
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1161)..(1161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1176)..(1176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1179)..(1179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1438)..(1438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1442)..(1442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1503)..(1503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1533)..(1533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1536)..(1536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1550)..(1550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1578)..(1578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1611)..(1611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1623)..(1623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1677)..(1677)
<223> Selenocysteine

<400> 3116
Ser Pro Gly Xaa Pro Gly Pro Xaa Met Gly Arg Ser Gln Gly Ser Pro 
1               5                   10                  15      


Met Asp Pro Met Val Met Lys Arg Pro Gln Leu Tyr Gly Met Gly Ser 
            20                  25                  30          


Asn Pro His Ser Gln Pro Gln Gln Ser Ser Pro Tyr Pro Gly Gly Ser 
        35                  40                  45              


Tyr Gly Pro Pro Gly Pro Gln Arg Tyr Pro Ile Gly Ile Gln Gly Arg 
    50                  55                  60                  


Xaa Pro Gly Ala Met Ala Gly Met Gln Tyr Pro Gln Gln Gln Met Pro 
65                  70                  75                  80  


Pro Gln Tyr Gly Gln Gln Gly Val Ser Gly Tyr Cys Gln Gln Gly Gln 
                85                  90                  95      


Gln Pro Tyr Tyr Ser Gln Gln Pro Gln Pro Pro His Leu Pro Pro Gln 
            100                 105                 110         


Ala Gln Tyr Leu Pro Ser Gln Ser Gln Gln Arg Tyr Gln Pro Gln Gln 
        115                 120                 125             


Asp Met Ser Gln Glu Gly Tyr Gly Xaa Arg Ser Gln Pro Pro Leu Ala 
    130                 135                 140                 


Pro Gly Lys Pro Asn His Glu Asp Leu Asn Leu Ile Gln Gln Glu Arg 
145                 150                 155                 160 


Pro Ser Ser Leu Pro Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Xaa 
                165                 170                 175     


Gly Xaa Glu Ala Xaa Leu Ser Ser Ala Val Ser Ala Ser Gly Ser Xaa 
            180                 185                 190         


Ser Ser Gln Gly Asp Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro 
        195                 200                 205             


His Ala Ser Pro His Leu Ser Ser Ile Pro Gly Gly Pro Ser Pro Ser 
    210                 215                 220                 


Pro Val Gly Ser Pro Val Gly Ser Asn Gln Ser Arg Ser Gly Pro Ile 
225                 230                 235                 240 


Ser Pro Ala Ser Ile Pro Gly Phe Met Ala Gly Xaa Gln Arg Asn Pro 
                245                 250                 255     


Gln Met Ala Gln Tyr Gly Pro Gln Gln Xaa Gly Pro Ser Met Ser Pro 
            260                 265                 270         


His Pro Ser Pro Gly Gly Gln Met His Ala Gly Ile Ser Ser Phe Gln 
        275                 280                 285             


Gln Ser Asn Ser Ser Gly Xaa Tyr Gly Pro Gln Met Ser Gln Tyr Gly 
    290                 295                 300                 


Pro Gln Gly Asn Tyr Ser Arg Pro Pro Ala Tyr Ser Gly Val Pro Ser 
305                 310                 315                 320 


Ala Ser Tyr Ser Gly Pro Gly Pro Gly Met Gly Ile Ser Ala Asn Asn 
                325                 330                 335     


Gln Met His Gly Gln Gly Pro Ser Gln Pro Cys Gly Ala Val Pro Leu 
            340                 345                 350         


Gly Arg Met Pro Ser Ala Gly Met Gln Asn Arg Pro Phe Pro Gly Asn 
        355                 360                 365             


Met Ser Ser Met Xaa Pro Ser Ser Pro Gly Met Ser Gln Gln Gly Gly 
    370                 375                 380                 


Pro Gly Met Gly Pro Pro Met Pro Xaa Val Asn Arg Lys Ala Gln Glu 
385                 390                 395                 400 


Ala Ala Ala Ala Val Met Gln Ala Ala Ala Asn Ser Ala Gln Ser Arg 
                405                 410                 415     


Gln Gly Ser Phe Pro Gly Met Asn Gln Ser Gly Leu Met Ala Ser Ser 
            420                 425                 430         


Ser Pro Tyr Ser Gln Pro Met Asn Asn Ser Ser Ser Leu Met Asn Xaa 
        435                 440                 445             


Gln Ala Pro Pro Tyr Ser Met Ala Pro Ala Met Val Asn Ser Ser Ala 
    450                 455                 460                 


Ala Ser Val Gly Leu Ala Asp Met Met Ser Pro Gly Glu Ser Lys Leu 
465                 470                 475                 480 


Pro Leu Pro Leu Lys Ala Asp Gly Lys Glu Glu Gly Xaa Pro Gln Pro 
                485                 490                 495     


Glu Ser Lys Ser Lys Asp Ser Tyr Ser Ser Gln Gly Ile Ser Gln Pro 
            500                 505                 510         


Pro Xaa Pro Gly Asn Leu Pro Val Pro Ser Pro Met Ser Pro Ser Ser 
        515                 520                 525             


Ala Ser Ile Ser Ser Phe His Gly Asp Glu Ser Asp Ser Ile Ser Ser 
    530                 535                 540                 


Pro Gly Trp Pro Lys Xaa Pro Ser Ser Pro Lys Ser Ser Ser Ser Xaa 
545                 550                 555                 560 


Xaa Xaa Gly Glu Lys Ile Xaa Lys Val Tyr Glu Leu Gly Asn Glu Pro 
                565                 570                 575     


Glu Arg Lys Leu Trp Val Asp Arg Tyr Leu Xaa Phe Met Glu Glu Arg 
            580                 585                 590         


Gly Ser Pro Val Ser Ser Leu Pro Ala Val Gly Lys Lys Pro Leu Asp 
        595                 600                 605             


Leu Phe Arg Leu Tyr Val Cys Val Lys Glu Ile Gly Gly Leu Ala Gln 
    610                 615                 620                 


Val Asn Lys Asn Lys Lys Trp Arg Glu Leu Ala Xaa Asn Leu Asn Val 
625                 630                 635                 640 


Gly Xaa Ser Ser Ser Ala Ala Ser Ser Leu Lys Lys Gln Tyr Ile Gln 
                645                 650                 655     


Tyr Leu Phe Ala Phe Glu Cys Lys Ile Glu Arg Gly Glu Glu Pro Pro 
            660                 665                 670         


Pro Glu Val Phe Ser Xaa Gly Asp Xaa Lys Lys Gln Pro Lys Leu Gln 
        675                 680                 685             


Pro Pro Ser Pro Ala Asn Ser Gly Ser Leu Gln Gly Pro Gln Xaa Pro 
    690                 695                 700                 


Gln Ser Xaa Gly Ser Asn Ser Met Ala Glu Val Pro Gly Asp Leu Lys 
705                 710                 715                 720 


Pro Pro Xaa Pro Ala Ser Xaa Pro His Gly Gln Met Xaa Pro Met Gln 
                725                 730                 735     


Gly Gly Arg Ser Ser Xaa Ile Ser Val His Asp Pro Phe Ser Asp Val 
            740                 745                 750         


Ser Asp Ser Ser Phe Pro Lys Arg Asn Ser Met Xaa Pro Asn Ala Pro 
        755                 760                 765             


Tyr Gln Gln Gly Met Ser Met Pro Asp Val Met Gly Arg Met Pro Tyr 
    770                 775                 780                 


Glu Pro Asn Lys Asp Pro Phe Gly Gly Met Arg Lys Val Pro Gly Ser 
785                 790                 795                 800 


Ser Glu Pro Phe Met Xaa Gln Gly Gln Met Pro Asn Ser Ser Met Gln 
                805                 810                 815     


Asp Met Tyr Asn Gln Ser Pro Ser Gly Ala Met Ser Asn Leu Gly Met 
            820                 825                 830         


Gly Gln Arg Gln Gln Phe Pro Tyr Gly Ala Ser Tyr Asp Arg Arg His 
        835                 840                 845             


Glu Pro Tyr Gly Gln Gln Tyr Pro Gly Gln Gly Pro Pro Ser Gly Gln 
    850                 855                 860                 


Pro Pro Tyr Gly Gly His Gln Pro Gly Leu Tyr Pro Gln Gln Pro Asn 
865                 870                 875                 880 


Tyr Lys Arg His Met Asp Gly Met Tyr Gly Pro Pro Ala Lys Arg His 
                885                 890                 895     


Glu Gly Asp Met Tyr Asn Met Gln Tyr Ser Ser Gln Gln Gln Glu Met 
            900                 905                 910         


Tyr Asn Gln Tyr Gly Gly Ser Tyr Ser Gly Pro Asp Arg Arg Pro Ile 
        915                 920                 925             


Gln Gly Gln Tyr Pro Tyr Pro Tyr Ser Arg Glu Arg Met Gln Gly Pro 
    930                 935                 940                 


Gly Gln Ile Gln Xaa His Gly Ile Pro Pro Gln Met Met Gly Gly Pro 
945                 950                 955                 960 


Leu Gln Ser Ser Ser Ser Glu Gly Pro Gln Gln Asn Met Trp Ala Ala 
                965                 970                 975     


Arg Asn Asp Met Pro Tyr Pro Tyr Gln Asn Arg Gln Gly Pro Gly Gly 
            980                 985                 990         


Pro Xaa Gln Ala Pro Pro Tyr Pro  Gly Met Asn Arg Xaa  Asp Asp Met 
        995                 1000                 1005             


Met Val  Pro Asp Gln Arg Ile  Asn His Glu Ser Gln  Trp Pro Ser 
    1010                 1015                 1020             


His Val  Ser Gln Arg Gln Pro  Tyr Met Ser Ser Ser  Ala Ser Met 
    1025                 1030                 1035             


Gln Pro  Ile Xaa Arg Pro Pro  Gln Pro Ser Tyr Gln  Xaa Pro Pro 
    1040                 1045                 1050             


Ser Leu  Pro Asn His Ile Ser  Arg Ala Pro Ser Pro  Ala Ser Phe 
    1055                 1060                 1065             


Gln Arg  Ser Leu Glu Asn Arg  Met Ser Pro Ser Lys  Ser Pro Phe 
    1070                 1075                 1080             


Leu Pro  Ser Met Lys Met Gln  Lys Val Met Pro Xaa  Val Pro Xaa 
    1085                 1090                 1095             


Ser Gln  Val Xaa Gly Pro Pro  Pro Gln Pro Pro Pro  Ile Arg Arg 
    1100                 1105                 1110             


Glu Ile  Xaa Phe Pro Pro Gly  Ser Val Glu Ala Ser  Gln Pro Val 
    1115                 1120                 1125             


Leu Lys  Gln Arg Arg Lys Ile  Xaa Ser Lys Asp Ile  Val Xaa Pro 
    1130                 1135                 1140             


Glu Ala  Trp Arg Val Met Met  Ser Leu Lys Ser Gly  Leu Leu Ala 
    1145                 1150                 1155             


Glu Ser  Xaa Trp Ala Leu Asp  Xaa Ile Asn Ile Leu  Leu Tyr Asp 
    1160                 1165                 1170             


Asp Ser  Xaa Val Ala Xaa Phe  Asn Leu Ser Gln Leu  Ser Gly Phe 
    1175                 1180                 1185             


Leu Glu  Leu Leu Val Glu Tyr  Phe Arg Lys Cys Leu  Ile Asp Ile 
    1190                 1195                 1200             


Phe Gly  Ile Leu Met Glu Tyr  Glu Val Gly Asp Pro  Ser Gln Lys 
    1205                 1210                 1215             


Ala Leu  Asp His Asn Ala Ala  Arg Lys Asp Asp Ser  Gln Ser Leu 
    1220                 1225                 1230             


Ala Asp  Asp Ser Gly Lys Glu  Glu Glu Asp Ala Glu  Cys Ile Asp 
    1235                 1240                 1245             


Asp Asp  Glu Glu Asp Glu Glu  Asp Glu Glu Glu Asp  Ser Glu Lys 
    1250                 1255                 1260             


Xaa Glu  Ser Asp Glu Lys Ser  Ser Ile Ala Leu Xaa  Ala Pro Asp 
    1265                 1270                 1275             


Ala Ala  Ala Asp Pro Lys Glu  Lys Pro Lys Gln Ala  Ser Lys Phe 
    1280                 1285                 1290             


Asp Lys  Leu Pro Ile Lys Ile  Val Lys Lys Asn Asn  Leu Phe Val 
    1295                 1300                 1305             


Val Asp  Arg Ser Asp Lys Leu  Gly Arg Val Gln Glu  Phe Asn Ser 
    1310                 1315                 1320             


Gly Leu  Leu His Trp Gln Leu  Gly Gly Gly Asp Xaa  Xaa Glu His 
    1325                 1330                 1335             


Ile Gln  Xaa His Phe Glu Ser  Lys Met Glu Ile Pro  Pro Arg Arg 
    1340                 1345                 1350             


Arg Pro  Pro Pro Pro Leu Ser  Ser Ala Gly Arg Lys  Lys Glu Gln 
    1355                 1360                 1365             


Glu Gly  Lys Gly Asp Ser Glu  Glu Gln Gln Glu Lys  Ser Ile Ile 
    1370                 1375                 1380             


Ala Xaa  Ile Asp Asp Val Leu  Ser Ala Arg Pro Gly  Ala Leu Pro 
    1385                 1390                 1395             


Glu Asp  Ala Asn Pro Gly Pro  Gln Xaa Glu Ser Ser  Lys Phe Pro 
    1400                 1405                 1410             


Phe Gly  Ile Gln Gln Ala Lys  Ser His Arg Asn Ile  Lys Leu Leu 
    1415                 1420                 1425             


Glu Asp  Glu Pro Arg Ser Arg  Asp Glu Xaa Pro Leu  Cys Xaa Ile 
    1430                 1435                 1440             


Ala His  Trp Gln Asp Ser Leu  Ala Lys Arg Cys Ile  Cys Val Ser 
    1445                 1450                 1455             


Asn Ile  Val Arg Ser Leu Ser  Phe Val Pro Gly Asn  Asp Ala Glu 
    1460                 1465                 1470             


Met Ser  Lys His Pro Gly Leu  Val Leu Ile Leu Gly  Lys Leu Ile 
    1475                 1480                 1485             


Leu Leu  His His Glu His Pro  Glu Arg Lys Arg Ala  Pro Gln Xaa 
    1490                 1495                 1500             


Tyr Glu  Lys Glu Glu Asp Glu  Asp Lys Gly Val Ala  Cys Ser Lys 
    1505                 1510                 1515             


Asp Glu  Trp Trp Trp Asp Cys  Leu Glu Val Leu Arg  Asp Asn Xaa 
    1520                 1525                 1530             


Leu Val  Xaa Leu Ala Asn Ile  Ser Gly Gln Leu Asp  Leu Ser Ala 
    1535                 1540                 1545             


Tyr Xaa  Glu Ser Ile Cys Leu  Pro Ile Leu Asp Gly  Leu Leu His 
    1550                 1555                 1560             


Trp Met  Val Cys Pro Ser Ala  Glu Ala Gln Asp Pro  Phe Pro Xaa 
    1565                 1570                 1575             


Val Gly  Pro Asn Ser Val Leu  Ser Pro Gln Arg Leu  Val Leu Glu 
    1580                 1585                 1590             


Xaa Leu  Cys Lys Leu Ser Ile  Gln Asp Asn Asn Val  Asp Leu Ile 
    1595                 1600                 1605             


Leu Ala  Xaa Pro Pro Phe Ser  Arg Gln Glu Lys Phe  Tyr Ala Xaa 
    1610                 1615                 1620             


Leu Val  Arg Tyr Val Gly Asp  Arg Lys Asn Pro Val  Cys Arg Glu 
    1625                 1630                 1635             


Met Ser  Met Ala Leu Leu Ser  Asn Leu Ala Gln Gly  Asp Ala Leu 
    1640                 1645                 1650             


Ala Ala  Arg Ala Ile Ala Val  Gln Lys Gly Ser Ile  Gly Asn Leu 
    1655                 1660                 1665             


Ile Ser  Phe Leu Glu Asp Gly  Val Xaa Met Ala Gln  Tyr Gln Gln 
    1670                 1675                 1680             


Ser Gln  His Asn Leu Met His  Met Gln Pro Pro Pro  Leu Glu Pro 
    1685                 1690                 1695             


Pro Ser  Val Asp Met Met Cys  Arg Ala Ala Lys Ala  Leu Leu Ala 
    1700                 1705                 1710             


Met Ala  Arg Val Asp Glu Asn  Arg Ser Glu Phe Leu  Leu His Glu 
    1715                 1720                 1725             


Gly Arg  Leu Leu Asp Ile Ser  Ile Ser Ala Val Leu  Asn Ser Leu 
    1730                 1735                 1740             


Val Ala  Ser Val Ile Cys Asp  Val Leu Phe Gln Ile  Gly Gln Leu 
    1745                 1750                 1755             


<210> 3117
<211> 312
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<400> 3117
Xaa Xaa Glu His Ile Gln Xaa His Phe Glu Ser Lys Met Glu Ile Pro 
1               5                   10                  15      


Pro Arg Arg Arg Pro Pro Pro Pro Leu Ser Ser Ala Gly Arg Lys Lys 
            20                  25                  30          


Glu Gln Glu Gly Lys Gly Asp Ser Glu Glu Gln Gln Glu Lys Ser Ile 
        35                  40                  45              


Ile Ala Xaa Ile Asp Asp Val Leu Ser Ala Arg Pro Gly Ala Leu Pro 
    50                  55                  60                  


Glu Asp Ala Asn Pro Gly Pro Gln Xaa Glu Ser Ser Lys Phe Pro Phe 
65                  70                  75                  80  


Gly Ile Gln Gln Ala Lys Ser His Arg Asn Ile Lys Leu Leu Glu Asp 
                85                  90                  95      


Glu Pro Arg Ser Arg Asp Glu Xaa Pro Leu Cys Xaa Ile Ala His Trp 
            100                 105                 110         


Gln Asp Ser Leu Ala Lys Arg Cys Ile Cys Val Ser Asn Ile Val Arg 
        115                 120                 125             


Ser Leu Ser Phe Val Pro Gly Asn Asp Ala Glu Met Ser Lys His Pro 
    130                 135                 140                 


Gly Leu Val Leu Ile Leu Gly Lys Leu Ile Leu Leu His His Glu His 
145                 150                 155                 160 


Pro Glu Arg Lys Arg Ala Pro Gln Xaa Tyr Glu Lys Glu Glu Asp Glu 
                165                 170                 175     


Asp Lys Gly Val Ala Cys Ser Lys Asp Glu Trp Trp Trp Asp Cys Leu 
            180                 185                 190         


Glu Val Leu Arg Asp Asn Xaa Leu Val Xaa Leu Ala Asn Ile Ser Gly 
        195                 200                 205             


Gln Leu Asp Leu Ser Ala Tyr Xaa Glu Ser Ile Cys Leu Pro Ile Leu 
    210                 215                 220                 


Asp Gly Leu Leu His Trp Met Val Cys Pro Ser Ala Glu Ala Gln Asp 
225                 230                 235                 240 


Pro Phe Pro Xaa Val Gly Pro Asn Ser Val Leu Ser Pro Gln Arg Leu 
                245                 250                 255     


Val Leu Glu Xaa Leu Cys Lys Leu Ser Ile Gln Asp Asn Asn Val Asp 
            260                 265                 270         


Leu Ile Leu Ala Xaa Pro Pro Phe Ser Arg Gln Glu Lys Phe Tyr Ala 
        275                 280                 285             


Xaa Leu Val Arg Asn Met Val Pro Leu Gly Trp Glu Gln Lys Gln Cys 
    290                 295                 300                 


Phe Leu Arg Leu Arg Ile His Xaa 
305                 310         


<210> 3118
<211> 26
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 3118
Xaa Ile Gln Gln Glu Arg Pro Ser Ser Leu Pro Val Glu Val Leu Ala 
1               5                   10                  15      


Ser Glu Asp Ala Ala Phe Gly Leu Lys Cys 
            20                  25      


<210> 3119
<211> 1495
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (873)..(873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1179)..(1179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1240)..(1240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1270)..(1270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1273)..(1273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1287)..(1287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1315)..(1315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1360)..(1360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<400> 3119
Xaa Asn Tyr Ser Arg Pro Pro Ala Tyr Ser Gly Val Pro Ser Ala Ser 
1               5                   10                  15      


Tyr Ser Gly Pro Gly Pro Gly Met Gly Ile Ser Ala Asn Asn Gln Met 
            20                  25                  30          


His Gly Gln Gly Pro Ser Gln Pro Cys Gly Ala Val Pro Leu Gly Arg 
        35                  40                  45              


Met Pro Ser Ala Gly Met Gln Asn Arg Pro Phe Pro Gly Asn Met Ser 
    50                  55                  60                  


Ser Met Xaa Pro Ser Ser Pro Gly Met Ser Gln Gln Gly Gly Pro Gly 
65                  70                  75                  80  


Met Gly Pro Pro Met Pro Xaa Val Asn Arg Lys Ala Gln Glu Ala Ala 
                85                  90                  95      


Ala Ala Val Met Gln Ala Ala Ala Asn Ser Ala Gln Ser Arg Pro Pro 
            100                 105                 110         


Tyr Ile Arg Ser Pro Ala Tyr Pro Ser Gln Ser Gly Ala Gly Gly Arg 
        115                 120                 125             


Pro Met Phe Ser Ser Gln His Pro Asn Tyr Gly Asn Ser Gln Ala Pro 
    130                 135                 140                 


Met Val His Gln Pro Asp Gln Tyr Gly Gln Gly Ser Phe Pro Gly Met 
145                 150                 155                 160 


Asn Gln Ser Gly Leu Met Ala Ser Ser Ser Pro Tyr Ser Gln Pro Met 
                165                 170                 175     


Asn Asn Ser Ser Ser Leu Met Asn Xaa Gln Ala Pro Pro Tyr Ser Met 
            180                 185                 190         


Ala Pro Ala Met Val Asn Ser Ser Ala Ala Ser Val Gly Leu Ala Asp 
        195                 200                 205             


Met Met Ser Pro Gly Glu Ser Lys Leu Pro Leu Pro Leu Lys Ala Asp 
    210                 215                 220                 


Gly Lys Glu Glu Gly Xaa Pro Gln Pro Glu Ser Lys Ser Lys Asp Ser 
225                 230                 235                 240 


Tyr Ser Ser Gln Gly Ile Ser Gln Pro Pro Xaa Pro Gly Asn Leu Pro 
                245                 250                 255     


Val Pro Ser Pro Met Ser Pro Ser Ser Ala Ser Ile Ser Ser Phe His 
            260                 265                 270         


Gly Asp Glu Ser Asp Ser Ile Ser Ser Pro Gly Trp Pro Lys Xaa Pro 
        275                 280                 285             


Ser Ser Pro Lys Ser Ser Ser Ser Xaa Xaa Xaa Gly Glu Lys Ile Xaa 
    290                 295                 300                 


Lys Val Tyr Glu Leu Gly Asn Glu Pro Glu Arg Lys Leu Trp Val Asp 
305                 310                 315                 320 


Arg Tyr Leu Xaa Phe Met Glu Glu Arg Gly Ser Pro Val Ser Ser Leu 
                325                 330                 335     


Pro Ala Val Gly Lys Lys Pro Leu Asp Leu Phe Arg Leu Tyr Val Cys 
            340                 345                 350         


Val Lys Glu Ile Gly Gly Leu Ala Gln Val Asn Lys Asn Lys Lys Trp 
        355                 360                 365             


Arg Glu Leu Ala Xaa Asn Leu Asn Val Gly Xaa Ser Ser Ser Ala Ala 
    370                 375                 380                 


Ser Ser Leu Lys Lys Gln Tyr Ile Gln Tyr Leu Phe Ala Phe Glu Cys 
385                 390                 395                 400 


Lys Ile Glu Arg Gly Glu Glu Pro Pro Pro Glu Val Phe Ser Xaa Gly 
                405                 410                 415     


Asp Xaa Lys Lys Gln Pro Lys Leu Gln Pro Pro Ser Pro Ala Asn Ser 
            420                 425                 430         


Gly Ser Leu Gln Gly Pro Gln Xaa Pro Gln Ser Xaa Gly Ser Asn Ser 
        435                 440                 445             


Met Ala Glu Val Pro Gly Asp Leu Lys Pro Pro Xaa Pro Ala Ser Xaa 
    450                 455                 460                 


Pro His Gly Gln Met Xaa Pro Met Gln Gly Gly Arg Ser Ser Xaa Ile 
465                 470                 475                 480 


Ser Val His Asp Pro Phe Ser Asp Val Ser Asp Ser Ser Phe Pro Lys 
                485                 490                 495     


Arg Asn Ser Met Xaa Pro Asn Ala Pro Tyr Gln Gln Gly Met Ser Met 
            500                 505                 510         


Pro Asp Val Met Gly Arg Met Pro Tyr Glu Pro Asn Lys Asp Pro Phe 
        515                 520                 525             


Gly Gly Met Arg Lys Val Pro Gly Ser Ser Glu Pro Phe Met Xaa Gln 
    530                 535                 540                 


Gly Gln Met Pro Asn Ser Ser Met Gln Asp Met Tyr Asn Gln Ser Pro 
545                 550                 555                 560 


Ser Gly Ala Met Ser Asn Leu Gly Met Gly Gln Arg Gln Gln Phe Pro 
                565                 570                 575     


Tyr Gly Ala Ser Tyr Asp Arg Arg His Glu Pro Tyr Gly Gln Gln Tyr 
            580                 585                 590         


Pro Gly Gln Gly Pro Pro Ser Gly Gln Pro Pro Tyr Gly Gly His Gln 
        595                 600                 605             


Pro Gly Leu Tyr Pro Gln Gln Pro Asn Tyr Lys Arg His Met Asp Gly 
    610                 615                 620                 


Met Tyr Gly Pro Pro Ala Lys Arg His Glu Gly Asp Met Tyr Asn Met 
625                 630                 635                 640 


Gln Tyr Ser Ser Gln Gln Gln Glu Met Tyr Asn Gln Tyr Gly Gly Ser 
                645                 650                 655     


Tyr Ser Gly Pro Asp Arg Arg Pro Ile Gln Gly Gln Tyr Pro Tyr Pro 
            660                 665                 670         


Tyr Ser Arg Glu Arg Met Gln Gly Pro Gly Gln Ile Gln Xaa His Gly 
        675                 680                 685             


Ile Pro Pro Gln Met Met Gly Gly Pro Leu Gln Ser Ser Ser Ser Glu 
    690                 695                 700                 


Gly Pro Gln Gln Asn Met Trp Ala Ala Arg Asn Asp Met Pro Tyr Pro 
705                 710                 715                 720 


Tyr Gln Asn Arg Gln Gly Pro Gly Gly Pro Xaa Gln Ala Pro Pro Tyr 
                725                 730                 735     


Pro Gly Met Asn Arg Xaa Asp Asp Met Met Val Pro Asp Gln Arg Ile 
            740                 745                 750         


Asn His Glu Ser Gln Trp Pro Ser His Val Ser Gln Arg Gln Pro Tyr 
        755                 760                 765             


Met Ser Ser Ser Ala Ser Met Gln Pro Ile Xaa Arg Pro Pro Gln Pro 
    770                 775                 780                 


Ser Tyr Gln Xaa Pro Pro Ser Leu Pro Asn His Ile Ser Arg Ala Pro 
785                 790                 795                 800 


Ser Pro Ala Ser Phe Gln Arg Ser Leu Glu Asn Arg Met Ser Pro Ser 
                805                 810                 815     


Lys Ser Pro Phe Leu Pro Ser Met Lys Met Gln Lys Val Met Pro Xaa 
            820                 825                 830         


Val Pro Xaa Ser Gln Val Xaa Gly Pro Pro Pro Gln Pro Pro Pro Ile 
        835                 840                 845             


Arg Arg Glu Ile Xaa Phe Pro Pro Gly Ser Val Glu Ala Ser Gln Pro 
    850                 855                 860                 


Val Leu Lys Gln Arg Arg Lys Ile Xaa Ser Lys Asp Ile Val Xaa Pro 
865                 870                 875                 880 


Glu Ala Trp Arg Val Met Met Ser Leu Lys Ser Gly Leu Leu Ala Glu 
                885                 890                 895     


Ser Xaa Trp Ala Leu Asp Xaa Ile Asn Ile Leu Leu Tyr Asp Asp Ser 
            900                 905                 910         


Xaa Val Ala Xaa Phe Asn Leu Ser Gln Leu Ser Gly Phe Leu Glu Leu 
        915                 920                 925             


Leu Val Glu Tyr Phe Arg Lys Cys Leu Ile Asp Ile Phe Gly Ile Leu 
    930                 935                 940                 


Met Glu Tyr Glu Val Gly Asp Pro Ser Gln Lys Ala Leu Asp His Asn 
945                 950                 955                 960 


Ala Ala Arg Lys Asp Asp Ser Gln Ser Leu Ala Asp Asp Ser Gly Lys 
                965                 970                 975     


Glu Glu Glu Asp Ala Glu Cys Ile Asp Asp Asp Glu Glu Asp Glu Glu 
            980                 985                 990         


Asp Glu Glu Glu Asp Ser Glu Lys  Xaa Glu Ser Asp Glu  Lys Ser Ser 
        995                 1000                 1005             


Ile Ala  Leu Xaa Ala Pro Asp  Ala Ala Ala Asp Pro  Lys Glu Lys 
    1010                 1015                 1020             


Pro Lys  Gln Ala Ser Lys Phe  Asp Lys Leu Pro Ile  Lys Ile Val 
    1025                 1030                 1035             


Lys Lys  Asn Asn Leu Phe Val  Val Asp Arg Ser Asp  Lys Leu Gly 
    1040                 1045                 1050             


Arg Val  Gln Glu Phe Asn Ser  Gly Leu Leu His Trp  Gln Leu Gly 
    1055                 1060                 1065             


Gly Gly  Asp Xaa Xaa Glu His  Ile Gln Xaa His Phe  Glu Ser Lys 
    1070                 1075                 1080             


Met Glu  Ile Pro Pro Arg Arg  Arg Pro Pro Pro Pro  Leu Ser Ser 
    1085                 1090                 1095             


Ala Gly  Arg Lys Lys Glu Gln  Glu Gly Lys Gly Asp  Ser Glu Glu 
    1100                 1105                 1110             


Gln Gln  Glu Lys Ser Ile Ile  Ala Xaa Ile Asp Asp  Val Leu Ser 
    1115                 1120                 1125             


Ala Arg  Pro Gly Ala Leu Pro  Glu Asp Ala Asn Pro  Gly Pro Gln 
    1130                 1135                 1140             


Xaa Glu  Ser Ser Lys Phe Pro  Phe Gly Ile Gln Gln  Ala Lys Ser 
    1145                 1150                 1155             


His Arg  Asn Ile Lys Leu Leu  Glu Asp Glu Pro Arg  Ser Arg Asp 
    1160                 1165                 1170             


Glu Xaa  Pro Leu Cys Xaa Ile  Ala His Trp Gln Asp  Ser Leu Ala 
    1175                 1180                 1185             


Lys Arg  Cys Ile Cys Val Ser  Asn Ile Val Arg Ser  Leu Ser Phe 
    1190                 1195                 1200             


Val Pro  Gly Asn Asp Ala Glu  Met Ser Lys His Pro  Gly Leu Val 
    1205                 1210                 1215             


Leu Ile  Leu Gly Lys Leu Ile  Leu Leu His His Glu  His Pro Glu 
    1220                 1225                 1230             


Arg Lys  Arg Ala Pro Gln Xaa  Tyr Glu Lys Glu Glu  Asp Glu Asp 
    1235                 1240                 1245             


Lys Gly  Val Ala Cys Ser Lys  Asp Glu Trp Trp Trp  Asp Cys Leu 
    1250                 1255                 1260             


Glu Val  Leu Arg Asp Asn Xaa  Leu Val Xaa Leu Ala  Asn Ile Ser 
    1265                 1270                 1275             


Gly Gln  Leu Asp Leu Ser Ala  Tyr Xaa Glu Ser Ile  Cys Leu Pro 
    1280                 1285                 1290             


Ile Leu  Asp Gly Leu Leu His  Trp Met Val Cys Pro  Ser Ala Glu 
    1295                 1300                 1305             


Ala Gln  Asp Pro Phe Pro Xaa  Val Gly Pro Asn Ser  Val Leu Ser 
    1310                 1315                 1320             


Pro Gln  Arg Leu Val Leu Glu  Xaa Leu Cys Lys Leu  Ser Ile Gln 
    1325                 1330                 1335             


Asp Asn  Asn Val Asp Leu Ile  Leu Ala Xaa Pro Pro  Phe Ser Arg 
    1340                 1345                 1350             


Gln Glu  Lys Phe Tyr Ala Xaa  Leu Val Arg Tyr Val  Gly Asp Arg 
    1355                 1360                 1365             


Lys Asn  Pro Val Cys Arg Glu  Met Ser Met Ala Leu  Leu Ser Asn 
    1370                 1375                 1380             


Leu Ala  Gln Gly Asp Ala Leu  Ala Ala Arg Ala Ile  Ala Val Gln 
    1385                 1390                 1395             


Lys Gly  Ser Ile Gly Asn Leu  Ile Ser Phe Leu Glu  Asp Gly Val 
    1400                 1405                 1410             


Xaa Met  Ala Gln Tyr Gln Gln  Ser Gln His Asn Leu  Met His Met 
    1415                 1420                 1425             


Gln Pro  Pro Pro Leu Glu Pro  Pro Ser Val Asp Met  Met Cys Arg 
    1430                 1435                 1440             


Ala Ala  Lys Ala Leu Leu Ala  Met Ala Arg Val Asp  Glu Asn Arg 
    1445                 1450                 1455             


Ser Glu  Phe Leu Leu His Glu  Gly Arg Leu Leu Asp  Ile Ser Ile 
    1460                 1465                 1470             


Ser Ala  Val Leu Asn Ser Leu  Val Ala Ser Val Ile  Cys Asp Val 
    1475                 1480                 1485             


Leu Phe  Gln Ile Gly Gln Leu  
    1490                 1495 


<210> 3120
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 3120
Xaa Ser Gln Gly Ser Pro Met Asp Pro Met Val Met Lys Arg Pro Gln 
1               5                   10                  15      


Leu Tyr Gly Met Gly Ser Asn Pro His Ser Gln Pro Gln Gln Ser Ser 
            20                  25                  30          


Pro Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly Pro Gln Arg Tyr Pro 
        35                  40                  45              


Ile Gly Ile Gln Gly Arg Xaa Pro Gly Ala Met Ala Gly Met Gln Tyr 
    50                  55                  60                  


Pro Gln Gln Gln Met Pro Pro Gln Tyr Gly Gln Gln Gly Val Ser Gly 
65                  70                  75                  80  


Tyr Cys Gln Gln Gly Gln Gln Pro Tyr Tyr Ser Gln Gln Pro Gln Pro 
                85                  90                  95      


Pro His Leu Pro Pro Gln Ala Gln Tyr Leu Pro Ser Gln Ser Gln Gln 
            100                 105                 110         


Arg Tyr Gln Pro Gln Gln Asp Met Ser Gln Glu Gly Tyr Gly Xaa Arg 
        115                 120                 125             


Ser Gln Pro Pro Leu Ala Pro Gly Lys Pro Asn His Glu Asp Leu Asn 
    130                 135                 140                 


Leu Ile Gln Gln Glu Arg Pro Ser Ser Leu Pro Arg Gly Ser Arg Ser 
145                 150                 155                 160 


Phe Ala Gln Ala Gly Met Gln Trp Cys Ser His Gly Xaa Leu Gln Pro 
                165                 170                 175     


Gln Pro Pro Trp Ala Gln Val Ile Leu Pro Pro Gln Pro His Glu 
            180                 185                 190     


<210> 3121
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<400> 3121
Xaa Xaa Pro Ser Ser Pro Gly Met Ser Gln Gln Gly Gly Pro Gly Met 
1               5                   10                  15      


Gly Pro Pro Met Pro Xaa Val Asn Arg Lys Ala Gln Glu Ala Ala Ala 
            20                  25                  30          


Ala Val Met Gln Ala Ala Ala Asn Ser Ala Gln Ser Arg Pro Pro Tyr 
        35                  40                  45              


Ile Arg Ser Pro Ala Tyr Pro Ser Gln Ser Gly Ala Gly Gly Arg Pro 
    50                  55                  60                  


Met Phe Ser Ser Gln His Pro Asn Tyr Gly Asn Ser Gln Ala Pro Met 
65                  70                  75                  80  


Val His Gln Pro Asp Gln Tyr Gly Asn Ser His Val Gln Gly Ile Asn 
                85                  90                  95      


<210> 3122
<211> 1835
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1173)..(1173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1193)..(1193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1206)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1208)..(1208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1234)..(1234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1276)..(1276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1278)..(1278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1316)..(1316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1398)..(1398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1402)..(1402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1406)..(1406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1422)..(1422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1439)..(1439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1474)..(1475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1509)..(1509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1514)..(1514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1522)..(1522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1526)..(1526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1540)..(1540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1552)..(1552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1564)..(1564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1583)..(1583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1593)..(1593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1645)..(1645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1655)..(1655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1684)..(1684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1715)..(1715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1719)..(1719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1723)..(1723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1726)..(1726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1757)..(1757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1765)..(1765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1771)..(1771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1810)..(1810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1821)..(1821)
<223> Selenocysteine

<400> 3122
Met Ala Asn Ser Xaa Gly Lys Ala Pro Pro Asp Glu Arg Arg Lys Gly 
1               5                   10                  15      


Leu Ala Phe Leu Asp Glu Leu Arg Gln Phe His His Ser Arg Gly Ser 
            20                  25                  30          


Pro Phe Lys Lys Ile Pro Ala Val Gly Gly Lys Glu Leu Asp Leu His 
        35                  40                  45              


Gly Leu Tyr Xaa Arg Val Xaa Xaa Leu Gly Gly Phe Ala Lys Val Ser 
    50                  55                  60                  


Glu Lys Asn Gln Trp Gly Glu Ile Val Glu Glu Phe Asn Phe Pro Arg 
65                  70                  75                  80  


Ser Cys Ser Asn Ala Ala Phe Ala Leu Lys Gln Tyr Tyr Leu Arg Tyr 
                85                  90                  95      


Leu Glu Lys Tyr Glu Lys Val His His Phe Gly Glu Asp Asp Asp Glu 
            100                 105                 110         


Val Pro Pro Gly Asn Pro Lys Pro Gln Leu Pro Ile Gly Ala Ile Pro 
        115                 120                 125             


Ser Ser Tyr Asn Tyr Gln Gln His Ser Val Ser Asp Tyr Leu Arg Gln 
    130                 135                 140                 


Ser Tyr Gly Leu Ser Met Asp Phe Asn Ser Pro Asn Asp Tyr Asn Lys 
145                 150                 155                 160 


Leu Val Leu Ser Leu Leu Ser Gly Leu Pro Asn Glu Val Asp Phe Ala 
                165                 170                 175     


Ile Asn Val Cys Xaa Leu Leu Ser Asn Glu Ser Lys His Val Met Gln 
            180                 185                 190         


Leu Glu Lys Asp Pro Lys Ile Ile Xaa Leu Leu Leu Ala Asn Ala Gly 
        195                 200                 205             


Val Phe Asp Asp Xaa Leu Gly Ser Phe Ser Xaa Val Phe Gly Glu Glu 
    210                 215                 220                 


Trp Lys Glu Lys Xaa Asp Arg Asp Phe Val Lys Phe Trp Lys Asp Ile 
225                 230                 235                 240 


Val Asp Asp Asn Glu Val Arg Asp Leu Ile Ser Asp Arg Asn Lys Ser 
                245                 250                 255     


His Glu Gly Xaa Ser Gly Glu Trp Ile Trp Glu Ser Leu Phe His Pro 
            260                 265                 270         


Pro Arg Lys Leu Gly Ile Asn Asp Ile Glu Gly Gln Arg Val Leu Gln 
        275                 280                 285             


Ile Ala Val Ile Leu Arg Asn Leu Ser Phe Glu Glu Gly Asn Val Lys 
    290                 295                 300                 


Leu Leu Ala Ala Asn Arg Xaa Cys Leu Arg Phe Leu Leu Leu Ser Ala 
305                 310                 315                 320 


His Ser His Phe Ile Ser Leu Arg Gln Leu Gly Leu Asp Xaa Leu Gly 
                325                 330                 335     


Asn Ile Ala Ala Glu Leu Leu Leu Asp Pro Val Asp Phe Lys Xaa Xaa 
            340                 345                 350         


His Leu Met Phe His Xaa Val Xaa Lys Cys Leu Met Ser Arg Asp Arg 
        355                 360                 365             


Phe Leu Lys Met Arg Gly Met Glu Ile Leu Gly Asn Leu Cys Lys Ala 
    370                 375                 380                 


Glu Asp Asn Gly Val Leu Ile Cys Glu Tyr Val Asp Gln Asp Ser Tyr 
385                 390                 395                 400 


Arg Glu Ile Ile Cys His Leu Xaa Leu Pro Asp Val Leu Leu Val Ile 
                405                 410                 415     


Ser Xaa Leu Glu Val Leu Tyr Met Leu Xaa Glu Met Gly Asp Val Ala 
            420                 425                 430         


Cys Xaa Lys Ile Ala Lys Val Glu Lys Ser Ile Asp Met Leu Val Cys 
        435                 440                 445             


Leu Val Ser Met Asp Ile Gln Met Phe Gly Pro Asp Ala Leu Ala Ala 
    450                 455                 460                 


Val Lys Leu Ile Glu His Pro Ser Ser Ser His Gln Met Leu Ser Glu 
465                 470                 475                 480 


Ile Arg Pro Gln Ala Ile Glu Gln Val Gln Xaa Gln Xaa His Val Ala 
                485                 490                 495     


Ser Ala Pro Ala Ser Arg Ala Val Val Ala Gln His Val Ala Pro Pro 
            500                 505                 510         


Pro Gly Ile Val Glu Ile Asp Ser Glu Lys Phe Ala Cys Gln Trp Leu 
        515                 520                 525             


Asn Ala His Phe Glu Val Asn Pro Asp Cys Ser Val Ser Arg Ala Glu 
    530                 535                 540                 


Met Tyr Ser Glu Tyr Leu Ser Xaa Cys Ser Lys Leu Ala Arg Gly Gly 
545                 550                 555                 560 


Ile Leu Xaa Ser Xaa Gly Phe Tyr Lys Cys Leu Arg Xaa Val Phe Pro 
                565                 570                 575     


Asn His Xaa Val Lys Arg Val Glu Asp Ser Ser Ser Asn Gly Gln Ala 
            580                 585                 590         


His Ile His Val Val Gly Val Lys Arg Arg Ala Ile Pro Leu Pro Ile 
        595                 600                 605             


Gln Met Tyr Tyr Gln Gln Gln Pro Val Ser Xaa Ser Val Val Arg Val 
    610                 615                 620                 


Asp Ser Val Pro Asp Val Ser Pro Ala Pro Ser Pro Ala Gly Ile Pro 
625                 630                 635                 640 


His Gly Ser Gln Xaa Ile Gly Asn His Phe Gln Arg Xaa Pro Val Ala 
                645                 650                 655     


Asn Gln Ser Ser Asn Leu Xaa Ala Xaa Gln Met Ser Phe Pro Val Gln 
            660                 665                 670         


Gly Val His Xaa Val Ala Gln Xaa Val Ser Arg Ile Pro Gln Asn Pro 
        675                 680                 685             


Ser Pro His Xaa His Gln Gln Gln Asn Ala Pro Val Xaa Val Ile Gln 
    690                 695                 700                 


Ser Lys Ala Pro Ile Pro Cys Glu Val Val Lys Ala Xaa Val Ile Gln 
705                 710                 715                 720 


Asn Ser Ile Pro Gln Xaa Gly Val Pro Val Ser Ile Ala Val Gly Gly 
                725                 730                 735     


Gly Pro Pro Gln Ser Ser Val Val Gln Asn His Ser Xaa Gly Pro Gln 
            740                 745                 750         


Pro Val Xaa Val Val Asn Ser Gln Xaa Leu Leu His His Pro Ser Val 
        755                 760                 765             


Ile Pro Gln Gln Ser Pro Leu His Xaa Val Val Pro Gly Gln Ile Pro 
    770                 775                 780                 


Ser Gly Xaa Pro Val Xaa Val Ile Gln Gln Ala Val Pro Gln Ser His 
785                 790                 795                 800 


Met Phe Gly Arg Val Gln Asn Ile Pro Ala Cys Xaa Ser Xaa Val Ser 
                805                 810                 815     


Gln Gly Gln Gln Leu Ile Xaa Xaa Ser Pro Gln Pro Val Gln Xaa Ser 
            820                 825                 830         


Ser Gln Gln Xaa Ser Ala Gly Ser Gln Ser Gln Asp Xaa Val Ile Ile 
        835                 840                 845             


Ala Pro Pro Gln Tyr Val Xaa Xaa Ser Ala Ser Asn Ile Val Ser Ala 
    850                 855                 860                 


Xaa Ser Val Gln Asn Phe Gln Val Ala Xaa Gly Gln Met Val Xaa Ile 
865                 870                 875                 880 


Ala Gly Val Pro Ser Pro Gln Ala Ser Arg Val Gly Phe Gln Asn Ile 
                885                 890                 895     


Ala Pro Lys Pro Leu Pro Ser Gln Gln Val Ser Ser Xaa Val Val Gln 
            900                 905                 910         


Gln Pro Ile Gln Gln Pro Gln Gln Pro Xaa Gln Gln Ser Val Val Ile 
        915                 920                 925             


Val Ser Gln Pro Ala Gln Gln Gly Gln Xaa Tyr Ala Pro Ala Ile His 
    930                 935                 940                 


Gln Ile Val Leu Ala Asn Pro Ala Ala Leu Pro Ala Gly Gln Xaa Val 
945                 950                 955                 960 


Gln Leu Xaa Gly Gln Pro Asn Ile Xaa Pro Ser Ser Ser Pro Ser Pro 
                965                 970                 975     


Val Pro Ala Xaa Asn Asn Gln Val Pro Xaa Ala Met Ser Ser Ser Ser 
            980                 985                 990         


Xaa Pro Gln Ser Gln Gly Pro Pro  Pro Xaa Val Ser Gln  Met Leu Ser 
        995                 1000                 1005             


Val Lys  Arg Gln Gln Gln Gln  Gln His Ser Pro Ala  Pro Pro Pro 
    1010                 1015                 1020             


Gln Gln  Val Gln Val Gln Val  Gln Gln Pro Gln Gln  Val Gln Met 
    1025                 1030                 1035             


Gln Val  Gln Pro Gln Gln Ser  Asn Ala Gly Val Gly  Gln Pro Ala 
    1040                 1045                 1050             


Ser Gly  Glu Ser Ser Leu Ile  Lys Gln Leu Leu Leu  Pro Lys Arg 
    1055                 1060                 1065             


Gly Pro  Ser Xaa Pro Gly Gly  Lys Leu Ile Leu Pro  Ala Pro Gln 
    1070                 1075                 1080             


Ile Pro  Pro Pro Asn Asn Ala  Arg Ala Pro Ser Pro  Gln Val Val 
    1085                 1090                 1095             


Tyr Gln  Val Ala Ser Asn Gln  Ala Ala Gly Phe Gly  Val Gln Gly 
    1100                 1105                 1110             


Gln Xaa  Pro Ala Gln Gln Leu  Leu Val Gly Gln Gln  Asn Val Gln 
    1115                 1120                 1125             


Leu Val  Pro Ser Ala Met Pro  Pro Ser Gly Gly Val  Gln Xaa Val 
    1130                 1135                 1140             


Pro Ile  Ser Asn Leu Gln Ile  Leu Pro Gly Pro Leu  Ile Ser Asn 
    1145                 1150                 1155             


Ser Pro  Ala Xaa Ile Phe Gln  Gly Xaa Ser Gly Asn  Gln Val Xaa 
    1160                 1165                 1170             


Ile Xaa  Val Val Pro Asn Xaa  Ser Phe Ala Pro Ala  Xaa Val Ser 
    1175                 1180                 1185             


Gln Gly  Asn Ala Xaa Gln Leu  Ile Ala Pro Ala Gly  Ile Xaa Met 
    1190                 1195                 1200             


Ser Gly  Xaa Gln Xaa Gly Val  Gly Leu Pro Val Gln  Xaa Leu Pro 
    1205                 1210                 1215             


Ala Xaa  Gln Ala Ser Pro Ala  Gly Gln Ser Ser Cys  Xaa Xaa Ala 
    1220                 1225                 1230             


Xaa Pro  Pro Phe Lys Gly Asp  Lys Ile Ile Cys Gln  Lys Glu Glu 
    1235                 1240                 1245             


Glu Ala  Lys Glu Ala Xaa Gly  Leu His Val His Glu  Arg Lys Ile 
    1250                 1255                 1260             


Glu Val  Met Glu Asn Pro Ser  Cys Arg Arg Gly Ala  Xaa Asn Xaa 
    1265                 1270                 1275             


Ser Asn  Gly Asp Xaa Lys Glu  Asn Glu Met His Val  Gly Ser Leu 
    1280                 1285                 1290             


Leu Asn  Gly Arg Lys Tyr Ser  Asp Ser Ser Leu Pro  Pro Ser Asn 
    1295                 1300                 1305             


Ser Gly  Lys Ile Gln Ser Glu  Xaa Asn Gln Cys Ser  Leu Ile Ser 
    1310                 1315                 1320             


Asn Gly  Pro Ser Leu Glu Leu  Gly Glu Asn Gly Ala  Ser Gly Lys 
    1325                 1330                 1335             


Gln Asn  Ser Glu Gln Ile Asp  Met Gln Asp Ile Lys  Ser Asp Leu 
    1340                 1345                 1350             


Arg Lys  Pro Leu Val Asn Gly  Ile Cys Asp Phe Asp  Lys Gly Asp 
    1355                 1360                 1365             


Gly Ser  His Leu Ser Lys Asn  Ile Pro Asn His Lys  Xaa Ser Asn 
    1370                 1375                 1380             


His Val  Gly Asn Gly Glu Ile  Ser Pro Met Glu Pro  Gln Gly Xaa 
    1385                 1390                 1395             


Leu Asp  Ile Xaa Gln Gln Asp  Xaa Ala Lys Gly Asp  Gln Leu Glu 
    1400                 1405                 1410             


Arg Ile  Ser Asn Gly Pro Val  Leu Xaa Leu Gly Gly  Ser Ser Val 
    1415                 1420                 1425             


Ser Ser  Ile Gln Glu Ala Ser  Asn Ala Ala Xaa Gln  Gln Phe Ser 
    1430                 1435                 1440             


Gly Xaa  Asp Leu Leu Asn Gly  Pro Leu Ala Ser Ser  Leu Asn Ser 
    1445                 1450                 1455             


Asp Val  Pro Gln Gln Arg Pro  Ser Val Val Val Ser  Pro His Ser 
    1460                 1465                 1470             


Xaa Xaa  Ser Val Ile Gln Gly  His Gln Ile Ile Ala  Val Pro Asp 
    1475                 1480                 1485             


Ser Gly  Ser Lys Val Ser His  Ser Pro Ala Leu Ser  Ser Asp Val 
    1490                 1495                 1500             


Arg Ser  Xaa Asn Gly Xaa Ala  Glu Cys Lys Xaa Val  Lys Arg Pro 
    1505                 1510                 1515             


Ala Glu  Asp Xaa Asp Arg Glu  Xaa Val Ala Gly Ile  Pro Asn Lys 
    1520                 1525                 1530             


Val Gly  Val Arg Ile Val Xaa  Ile Ser Asp Pro Asn  Asn Ala Gly 
    1535                 1540                 1545             


Cys Ser  Ala Xaa Met Val Ala  Val Pro Ala Gly Ala  Asp Pro Ser 
    1550                 1555                 1560             


Xaa Val  Ala Lys Val Ala Ile  Glu Ser Ala Val Gln  Gln Lys Gln 
    1565                 1570                 1575             


Gln His  Pro Pro Xaa Tyr Val  Gln Asn Val Val Pro  Gln Asn Xaa 
    1580                 1585                 1590             


Pro Met  Pro Pro Ser Pro Ala  Val Gln Val Gln Gly  Gln Pro Asn 
    1595                 1600                 1605             


Ser Ser  Gln Pro Ser Pro Phe  Ser Gly Ser Ser Gln  Pro Gly Asp 
    1610                 1615                 1620             


Pro Met  Arg Lys Pro Gly Gln  Asn Phe Met Cys Leu  Trp Gln Ser 
    1625                 1630                 1635             


Cys Lys  Lys Trp Phe Gln Xaa  Pro Ser Gln Val Phe  Tyr His Ala 
    1640                 1645                 1650             


Ala Xaa  Glu His Gly Gly Lys  Asp Val Tyr Pro Gly  Gln Cys Leu 
    1655                 1660                 1665             


Trp Glu  Gly Cys Glu Pro Phe  Gln Arg Gln Arg Phe  Ser Phe Ile 
    1670                 1675                 1680             


Xaa His  Leu Gln Asp Lys His  Cys Ser Lys Asp Ala  Leu Leu Ala 
    1685                 1690                 1695             


Gly Leu  Lys Gln Asp Glu Pro  Gly Gln Ala Gly Ser  Gln Lys Ser 
    1700                 1705                 1710             


Ser Xaa  Lys Gln Pro Xaa Val  Gly Gly Xaa Ser Ser  Xaa Pro Arg 
    1715                 1720                 1725             


Ala Gln  Lys Ala Ile Val Asn  His Pro Ser Ala Ala  Leu Met Ala 
    1730                 1735                 1740             


Leu Arg  Arg Gly Ser Arg Asn  Leu Val Phe Arg Asp  Phe Xaa Asp 
    1745                 1750                 1755             


Glu Lys  Glu Gly Pro Ile Xaa  Lys His Ile Arg Leu  Xaa Ala Ala 
    1760                 1765                 1770             


Leu Ile  Leu Lys Asn Ile Gly  Lys Tyr Ser Glu Cys  Gly Arg Arg 
    1775                 1780                 1785             


Leu Leu  Lys Arg His Glu Asn  Asn Leu Ser Val Leu  Ala Ile Ser 
    1790                 1795                 1800             


Asn Met  Glu Ala Ser Ser Xaa  Leu Ala Lys Cys Leu  Tyr Glu Leu 
    1805                 1810                 1815             


Asn Phe  Xaa Val Gln Ser Lys  Glu Gln Glu Lys Asp  Ser Glu Met 
    1820                 1825                 1830             


Leu Gln  
    1835 


<210> 3123
<211> 1639
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1071)..(1071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1105)..(1105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1253)..(1253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1273)..(1273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1296)..(1296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1325)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1357)..(1357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1360)..(1360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1365)..(1365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1377)..(1377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1391)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1403)..(1403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1415)..(1415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1444)..(1444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1496)..(1496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1535)..(1535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1566)..(1566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1570)..(1570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1577)..(1577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1608)..(1608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1616)..(1616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1622)..(1622)
<223> Selenocysteine

<400> 3123
Met Asp Phe Asn Ser Pro Asn Asp Tyr Asn Lys Leu Val Leu Ser Leu 
1               5                   10                  15      


Leu Ser Gly Leu Pro Asn Glu Val Asp Phe Ala Ile Asn Val Cys Xaa 
            20                  25                  30          


Leu Leu Ser Asn Glu Ser Lys His Val Met Gln Leu Glu Lys Asp Pro 
        35                  40                  45              


Lys Ile Ile Xaa Leu Leu Leu Ala Asn Ala Gly Val Phe Asp Asp Xaa 
    50                  55                  60                  


Leu Gly Ser Phe Ser Xaa Val Phe Gly Glu Glu Trp Lys Glu Lys Xaa 
65                  70                  75                  80  


Asp Arg Asp Phe Val Lys Phe Trp Lys Asp Ile Val Asp Asp Asn Glu 
                85                  90                  95      


Val Arg Asp Leu Ile Ser Asp Arg Asn Lys Ser His Glu Gly Xaa Ser 
            100                 105                 110         


Gly Glu Trp Ile Trp Glu Ser Leu Phe His Pro Pro Arg Lys Leu Gly 
        115                 120                 125             


Ile Asn Asp Ile Glu Gly Gln Arg Val Leu Gln Ile Ala Val Ile Leu 
    130                 135                 140                 


Arg Asn Leu Ser Phe Glu Glu Gly Asn Val Lys Leu Leu Ala Ala Asn 
145                 150                 155                 160 


Arg Xaa Cys Leu Arg Phe Leu Leu Leu Ser Ala His Ser His Phe Ile 
                165                 170                 175     


Ser Leu Arg Gln Leu Gly Leu Asp Xaa Leu Gly Asn Ile Ala Ala Glu 
            180                 185                 190         


Leu Leu Leu Asp Pro Val Asp Phe Lys Xaa Xaa His Leu Met Phe His 
        195                 200                 205             


Xaa Val Xaa Lys Cys Leu Met Ser Arg Asp Arg Phe Leu Lys Met Arg 
    210                 215                 220                 


Gly Met Glu Ile Leu Gly Asn Leu Cys Lys Ala Glu Asp Asn Gly Val 
225                 230                 235                 240 


Leu Ile Cys Glu Tyr Val Asp Gln Asp Ser Tyr Arg Glu Ile Ile Cys 
                245                 250                 255     


His Leu Xaa Leu Pro Asp Val Leu Leu Val Ile Ser Xaa Leu Glu Val 
            260                 265                 270         


Leu Tyr Met Leu Xaa Glu Met Gly Asp Val Ala Cys Xaa Lys Ile Ala 
        275                 280                 285             


Lys Val Glu Lys Ser Ile Asp Met Leu Val Cys Leu Val Ser Met Asp 
    290                 295                 300                 


Ile Gln Met Phe Gly Pro Asp Ala Leu Ala Ala Val Lys Leu Ile Glu 
305                 310                 315                 320 


His Pro Ser Ser Ser His Gln Met Leu Ser Glu Ile Arg Pro Gln Ala 
                325                 330                 335     


Ile Glu Gln Val Gln Xaa Gln Xaa His Val Ala Ser Ala Pro Ala Ser 
            340                 345                 350         


Arg Ala Val Val Ala Gln His Val Ala Pro Pro Pro Gly Ile Val Glu 
        355                 360                 365             


Ile Asp Ser Glu Lys Phe Ala Cys Gln Trp Leu Asn Ala His Phe Glu 
    370                 375                 380                 


Val Asn Pro Asp Cys Ser Val Ser Arg Ala Glu Met Tyr Ser Glu Tyr 
385                 390                 395                 400 


Leu Ser Xaa Cys Ser Lys Leu Ala Arg Gly Gly Ile Leu Xaa Ser Xaa 
                405                 410                 415     


Gly Phe Tyr Lys Cys Leu Arg Xaa Val Phe Pro Asn His Xaa Val Lys 
            420                 425                 430         


Arg Val Glu Asp Ser Ser Ser Asn Gly Gln Ala His Ile His Val Val 
        435                 440                 445             


Gly Val Lys Arg Arg Ala Ile Pro Leu Pro Ile Gln Met Tyr Tyr Gln 
    450                 455                 460                 


Gln Gln Pro Val Ser Xaa Ser Val Val Arg Val Asp Ser Val Pro Asp 
465                 470                 475                 480 


Val Ser Pro Ala Pro Ser Pro Ala Gly Ile Pro His Gly Ser Gln Xaa 
                485                 490                 495     


Ile Gly Asn His Phe Gln Arg Xaa Pro Val Ala Asn Gln Ser Ser Asn 
            500                 505                 510         


Leu Xaa Ala Xaa Gln Met Ser Phe Pro Val Gln Gly Val His Xaa Val 
        515                 520                 525             


Ala Gln Xaa Val Ser Arg Ile Pro Gln Asn Pro Ser Pro His Xaa His 
    530                 535                 540                 


Gln Gln Gln Asn Ala Pro Val Xaa Val Ile Gln Ser Lys Ala Pro Ile 
545                 550                 555                 560 


Pro Cys Glu Val Val Lys Ala Xaa Val Ile Gln Asn Ser Ile Pro Gln 
                565                 570                 575     


Xaa Gly Val Pro Val Ser Ile Ala Val Gly Gly Gly Pro Pro Gln Ser 
            580                 585                 590         


Ser Val Val Gln Asn His Ser Xaa Gly Pro Gln Pro Val Xaa Val Val 
        595                 600                 605             


Asn Ser Gln Xaa Leu Leu His His Pro Ser Val Ile Pro Gln Gln Ser 
    610                 615                 620                 


Pro Leu His Xaa Val Val Pro Gly Gln Ile Pro Ser Gly Xaa Pro Val 
625                 630                 635                 640 


Xaa Val Ile Gln Gln Ala Val Pro Gln Ser His Met Phe Gly Arg Val 
                645                 650                 655     


Gln Asn Ile Pro Ala Cys Xaa Ser Xaa Val Ser Gln Gly Gln Gln Leu 
            660                 665                 670         


Ile Xaa Xaa Ser Pro Gln Pro Val Gln Xaa Ser Ser Gln Gln Xaa Ser 
        675                 680                 685             


Ala Gly Ser Gln Ser Gln Asp Xaa Val Ile Ile Ala Pro Pro Gln Tyr 
    690                 695                 700                 


Val Xaa Xaa Ser Ala Ser Asn Ile Val Ser Ala Xaa Ser Val Gln Asn 
705                 710                 715                 720 


Phe Gln Val Ala Xaa Gly Gln Met Val Xaa Ile Ala Gly Val Pro Ser 
                725                 730                 735     


Pro Gln Ala Ser Arg Val Gly Phe Gln Asn Ile Ala Pro Lys Pro Leu 
            740                 745                 750         


Pro Ser Gln Gln Val Ser Ser Xaa Val Val Gln Gln Pro Ile Gln Gln 
        755                 760                 765             


Pro Gln Gln Pro Xaa Gln Gln Ser Val Val Ile Val Ser Gln Pro Ala 
    770                 775                 780                 


Gln Gln Gly Gln Xaa Tyr Ala Pro Ala Ile His Gln Ile Val Leu Ala 
785                 790                 795                 800 


Asn Pro Ala Ala Leu Pro Ala Gly Gln Xaa Val Gln Leu Xaa Gly Gln 
                805                 810                 815     


Pro Asn Ile Xaa Pro Ser Ser Ser Pro Ser Pro Val Pro Ala Xaa Asn 
            820                 825                 830         


Asn Gln Val Pro Xaa Ala Met Ser Ser Ser Ser Xaa Pro Gln Ser Gln 
        835                 840                 845             


Gly Pro Pro Pro Xaa Val Ser Gln Met Leu Ser Val Lys Arg Gln Gln 
    850                 855                 860                 


Gln Gln Gln His Ser Pro Ala Pro Pro Pro Gln Gln Val Gln Val Gln 
865                 870                 875                 880 


Val Gln Gln Pro Gln Gln Val Gln Met Gln Val Gln Pro Gln Gln Ser 
                885                 890                 895     


Asn Ala Gly Val Gly Gln Pro Ala Ser Gly Glu Ser Ser Leu Ile Lys 
            900                 905                 910         


Gln Leu Leu Leu Pro Lys Arg Gly Pro Ser Xaa Pro Gly Gly Lys Leu 
        915                 920                 925             


Ile Leu Pro Ala Pro Gln Ile Pro Pro Pro Asn Asn Ala Arg Ala Pro 
    930                 935                 940                 


Ser Pro Gln Val Val Tyr Gln Val Ala Ser Asn Gln Ala Ala Gly Phe 
945                 950                 955                 960 


Gly Val Gln Gly Gln Xaa Pro Ala Gln Gln Leu Leu Val Gly Gln Gln 
                965                 970                 975     


Asn Val Gln Leu Val Pro Ser Ala Met Pro Pro Ser Gly Gly Val Gln 
            980                 985                 990         


Xaa Val Pro Ile Ser Asn Leu Gln  Ile Leu Pro Gly Pro  Leu Ile Ser 
        995                 1000                 1005             


Asn Ser  Pro Ala Xaa Ile Phe  Gln Gly Xaa Ser Gly  Asn Gln Val 
    1010                 1015                 1020             


Xaa Ile  Xaa Val Val Pro Asn  Xaa Ser Phe Ala Pro  Ala Xaa Val 
    1025                 1030                 1035             


Ser Gln  Gly Asn Ala Xaa Gln  Leu Ile Ala Pro Ala  Gly Ile Xaa 
    1040                 1045                 1050             


Met Ser  Gly Xaa Gln Xaa Gly  Val Gly Leu Pro Val  Gln Xaa Leu 
    1055                 1060                 1065             


Pro Ala  Xaa Gln Ala Ser Pro  Ala Gly Gln Ser Ser  Cys Xaa Xaa 
    1070                 1075                 1080             


Ala Xaa  Pro Pro Phe Lys Gly  Asp Lys Ile Ile Cys  Gln Lys Glu 
    1085                 1090                 1095             


Glu Glu  Ala Lys Glu Ala Xaa  Gly Leu His Val His  Glu Arg Lys 
    1100                 1105                 1110             


Ile Glu  Val Met Glu Asn Pro  Ser Cys Arg Arg Gly  Ala Xaa Asn 
    1115                 1120                 1125             


Xaa Ser  Asn Gly Asp Xaa Lys  Glu Asn Glu Met His  Val Gly Ser 
    1130                 1135                 1140             


Leu Leu  Asn Gly Arg Lys Tyr  Ser Asp Ser Ser Leu  Pro Pro Ser 
    1145                 1150                 1155             


Asn Ser  Gly Lys Ile Gln Ser  Glu Xaa Asn Gln Cys  Ser Leu Ile 
    1160                 1165                 1170             


Ser Asn  Gly Pro Ser Leu Glu  Leu Gly Glu Asn Gly  Ala Ser Gly 
    1175                 1180                 1185             


Lys Gln  Asn Ser Glu Gln Ile  Asp Met Gln Asp Ile  Lys Ser Asp 
    1190                 1195                 1200             


Leu Arg  Lys Pro Leu Val Asn  Gly Ile Cys Asp Phe  Asp Lys Gly 
    1205                 1210                 1215             


Asp Gly  Ser His Leu Ser Lys  Asn Ile Pro Asn His  Lys Xaa Ser 
    1220                 1225                 1230             


Asn His  Val Gly Asn Gly Glu  Ile Ser Pro Met Glu  Pro Gln Gly 
    1235                 1240                 1245             


Xaa Leu  Asp Ile Xaa Gln Gln  Asp Xaa Ala Lys Gly  Asp Gln Leu 
    1250                 1255                 1260             


Glu Arg  Ile Ser Asn Gly Pro  Val Leu Xaa Leu Gly  Gly Ser Ser 
    1265                 1270                 1275             


Val Ser  Ser Ile Gln Glu Ala  Ser Asn Ala Ala Xaa  Gln Gln Phe 
    1280                 1285                 1290             


Ser Gly  Xaa Asp Leu Leu Asn  Gly Pro Leu Ala Ser  Ser Leu Asn 
    1295                 1300                 1305             


Ser Asp  Val Pro Gln Gln Arg  Pro Ser Val Val Val  Ser Pro His 
    1310                 1315                 1320             


Ser Xaa  Xaa Ser Val Ile Gln  Gly His Gln Ile Ile  Ala Val Pro 
    1325                 1330                 1335             


Asp Ser  Gly Ser Lys Val Ser  His Ser Pro Ala Leu  Ser Ser Asp 
    1340                 1345                 1350             


Val Arg  Ser Xaa Asn Gly Xaa  Ala Glu Cys Lys Xaa  Val Lys Arg 
    1355                 1360                 1365             


Pro Ala  Glu Asp Xaa Asp Arg  Glu Xaa Val Ala Gly  Ile Pro Asn 
    1370                 1375                 1380             


Lys Val  Gly Val Arg Ile Val  Xaa Ile Ser Asp Pro  Asn Asn Ala 
    1385                 1390                 1395             


Gly Cys  Ser Ala Xaa Met Val  Ala Val Pro Ala Gly  Ala Asp Pro 
    1400                 1405                 1410             


Ser Xaa  Val Ala Lys Val Ala  Ile Glu Ser Ala Val  Gln Gln Lys 
    1415                 1420                 1425             


Gln Gln  His Pro Pro Xaa Tyr  Val Gln Asn Val Val  Pro Gln Asn 
    1430                 1435                 1440             


Xaa Pro  Met Pro Pro Ser Pro  Ala Val Gln Val Gln  Gly Gln Pro 
    1445                 1450                 1455             


Asn Ser  Ser Gln Pro Ser Pro  Phe Ser Gly Ser Ser  Gln Pro Gly 
    1460                 1465                 1470             


Asp Pro  Met Arg Lys Pro Gly  Gln Asn Phe Met Cys  Leu Trp Gln 
    1475                 1480                 1485             


Ser Cys  Lys Lys Trp Phe Gln  Xaa Pro Ser Gln Val  Phe Tyr His 
    1490                 1495                 1500             


Ala Ala  Xaa Glu His Gly Gly  Lys Asp Val Tyr Pro  Gly Gln Cys 
    1505                 1510                 1515             


Leu Trp  Glu Gly Cys Glu Pro  Phe Gln Arg Gln Arg  Phe Ser Phe 
    1520                 1525                 1530             


Ile Xaa  His Leu Gln Asp Lys  His Cys Ser Lys Asp  Ala Leu Leu 
    1535                 1540                 1545             


Ala Gly  Leu Lys Gln Asp Glu  Pro Gly Gln Ala Gly  Ser Gln Lys 
    1550                 1555                 1560             


Ser Ser  Xaa Lys Gln Pro Xaa  Val Gly Gly Xaa Ser  Ser Xaa Pro 
    1565                 1570                 1575             


Arg Ala  Gln Lys Ala Ile Val  Asn His Pro Ser Ala  Ala Leu Met 
    1580                 1585                 1590             


Ala Leu  Arg Arg Gly Ser Arg  Asn Leu Val Phe Arg  Asp Phe Xaa 
    1595                 1600                 1605             


Asp Glu  Lys Glu Gly Pro Ile  Xaa Lys His Ile Arg  Leu Xaa Ala 
    1610                 1615                 1620             


Ala Leu  Ile Leu Lys Asn Ile  Gly Lys Tyr Ser Glu  Cys Gly Arg 
    1625                 1630                 1635             


Arg 
    


<210> 3124
<211> 401
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<400> 3124
Met Glu Pro Gln Gly Xaa Leu Asp Ile Xaa Gln Gln Asp Xaa Ala Lys 
1               5                   10                  15      


Gly Asp Gln Leu Glu Arg Ile Ser Asn Gly Pro Val Leu Xaa Leu Gly 
            20                  25                  30          


Gly Ser Ser Val Ser Ser Ile Gln Glu Ala Ser Asn Ala Ala Xaa Gln 
        35                  40                  45              


Gln Phe Ser Gly Xaa Asp Leu Leu Asn Gly Pro Leu Ala Ser Ser Leu 
    50                  55                  60                  


Asn Ser Asp Val Pro Gln Gln Arg Pro Ser Val Val Val Ser Pro His 
65                  70                  75                  80  


Ser Xaa Xaa Ser Val Ile Gln Gly His Gln Ile Ile Ala Val Pro Asp 
                85                  90                  95      


Ser Gly Ser Lys Val Ser His Ser Pro Ala Leu Ser Ser Asp Val Arg 
            100                 105                 110         


Ser Xaa Asn Gly Xaa Ala Glu Cys Lys Xaa Val Lys Arg Pro Ala Glu 
        115                 120                 125             


Asp Xaa Asp Arg Glu Xaa Val Ala Gly Ile Pro Asn Lys Val Gly Val 
    130                 135                 140                 


Arg Ile Val Xaa Ile Ser Asp Pro Asn Asn Ala Gly Cys Ser Ala Xaa 
145                 150                 155                 160 


Met Val Ala Val Pro Ala Gly Ala Asp Pro Ser Xaa Val Ala Lys Val 
                165                 170                 175     


Ala Ile Glu Ser Ala Val Gln Gln Lys Gln Gln His Pro Pro Xaa Tyr 
            180                 185                 190         


Val Gln Asn Val Val Pro Gln Asn Xaa Pro Met Pro Pro Ser Pro Ala 
        195                 200                 205             


Val Gln Val Gln Gly Gln Pro Asn Ser Ser Gln Pro Ser Pro Phe Ser 
    210                 215                 220                 


Gly Ser Ser Gln Pro Gly Asp Pro Met Arg Lys Pro Gly Gln Asn Phe 
225                 230                 235                 240 


Met Cys Leu Trp Gln Ser Cys Lys Lys Trp Phe Gln Xaa Pro Ser Gln 
                245                 250                 255     


Val Phe Tyr His Ala Ala Xaa Glu His Gly Gly Lys Asp Val Tyr Pro 
            260                 265                 270         


Gly Gln Cys Leu Trp Glu Gly Cys Glu Pro Phe Gln Arg Gln Arg Phe 
        275                 280                 285             


Ser Phe Ile Xaa His Leu Gln Asp Lys His Cys Ser Lys Asp Ala Leu 
    290                 295                 300                 


Leu Ala Gly Leu Lys Gln Asp Glu Pro Gly Gln Ala Gly Ser Gln Lys 
305                 310                 315                 320 


Ser Ser Xaa Lys Gln Pro Xaa Val Gly Gly Xaa Ser Ser Xaa Pro Arg 
                325                 330                 335     


Ala Gln Lys Ala Ile Val Asn His Pro Ser Ala Ala Leu Met Ala Leu 
            340                 345                 350         


Arg Arg Gly Ser Arg Asn Leu Val Phe Arg Asp Phe Xaa Asp Glu Lys 
        355                 360                 365             


Glu Gly Pro Ile Xaa Lys His Ile Arg Leu Xaa Ala Ala Leu Ile Leu 
    370                 375                 380                 


Lys Asn Ile Gly Lys Tyr Ser Glu Cys Gly Arg Arg Asn Met Asn Glu 
385                 390                 395                 400 


Asp 
    


<210> 3125
<211> 1445
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1193)..(1193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1255)..(1255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1294)..(1294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1325)..(1325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1367)..(1367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1375)..(1375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1431)..(1431)
<223> Selenocysteine

<400> 3125
Met Arg Gly Met Glu Ile Leu Gly Asn Leu Cys Lys Ala Glu Asp Asn 
1               5                   10                  15      


Gly Val Leu Ile Cys Glu Tyr Val Asp Gln Asp Ser Tyr Arg Glu Ile 
            20                  25                  30          


Ile Cys His Leu Xaa Leu Pro Asp Val Leu Leu Val Ile Ser Xaa Leu 
        35                  40                  45              


Glu Val Leu Tyr Met Leu Xaa Glu Met Gly Asp Val Ala Cys Xaa Lys 
    50                  55                  60                  


Ile Ala Lys Val Glu Lys Ser Ile Ala Ala Val Lys Leu Ile Glu His 
65                  70                  75                  80  


Pro Ser Ser Ser His Gln Met Leu Ser Glu Ile Arg Pro Gln Ala Ile 
                85                  90                  95      


Glu Gln Val Gln Xaa Gln Xaa His Val Ala Ser Ala Pro Ala Ser Arg 
            100                 105                 110         


Ala Val Val Ala Gln His Val Ala Pro Pro Pro Gly Ile Val Glu Ile 
        115                 120                 125             


Asp Ser Glu Lys Phe Ala Cys Gln Trp Leu Asn Ala His Phe Glu Val 
    130                 135                 140                 


Asn Pro Asp Cys Ser Val Ser Arg Ala Glu Met Tyr Ser Glu Tyr Leu 
145                 150                 155                 160 


Ser Xaa Cys Ser Lys Leu Ala Arg Gly Gly Ile Leu Xaa Ser Xaa Gly 
                165                 170                 175     


Phe Tyr Lys Cys Leu Arg Xaa Val Phe Pro Asn His Xaa Val Lys Arg 
            180                 185                 190         


Val Glu Asp Ser Ser Ser Asn Gly Gln Ala His Ile His Val Val Gly 
        195                 200                 205             


Val Lys Arg Arg Ala Ile Pro Leu Pro Ile Gln Met Tyr Tyr Gln Gln 
    210                 215                 220                 


Gln Pro Val Ser Xaa Ser Val Val Arg Val Asp Ser Val Pro Asp Val 
225                 230                 235                 240 


Ser Pro Ala Pro Ser Pro Ala Gly Ile Pro His Gly Ser Gln Xaa Ile 
                245                 250                 255     


Gly Asn His Phe Gln Arg Xaa Pro Val Ala Asn Gln Ser Ser Asn Leu 
            260                 265                 270         


Xaa Ala Xaa Gln Met Ser Phe Pro Val Gln Gly Val His Xaa Val Ala 
        275                 280                 285             


Gln Xaa Val Ser Arg Ile Pro Gln Asn Pro Ser Pro His Xaa His Gln 
    290                 295                 300                 


Gln Gln Asn Ala Pro Val Xaa Val Ile Gln Ser Lys Ala Pro Ile Pro 
305                 310                 315                 320 


Cys Glu Val Val Lys Ala Xaa Val Ile Gln Asn Ser Ile Pro Gln Xaa 
                325                 330                 335     


Gly Val Pro Val Ser Ile Ala Val Gly Gly Gly Pro Pro Gln Ser Ser 
            340                 345                 350         


Val Val Gln Asn His Ser Xaa Gly Pro Gln Pro Val Xaa Val Val Asn 
        355                 360                 365             


Ser Gln Xaa Leu Leu His His Pro Ser Val Ile Pro Gln Gln Ser Pro 
    370                 375                 380                 


Leu His Xaa Val Val Pro Gly Gln Ile Pro Ser Gly Xaa Pro Val Xaa 
385                 390                 395                 400 


Val Ile Gln Gln Ala Val Pro Gln Ser His Met Phe Gly Arg Val Gln 
                405                 410                 415     


Asn Ile Pro Ala Cys Xaa Ser Xaa Val Ser Gln Gly Gln Gln Leu Ile 
            420                 425                 430         


Xaa Xaa Ser Pro Gln Pro Val Gln Xaa Ser Ser Gln Gln Xaa Ser Ala 
        435                 440                 445             


Gly Ser Gln Ser Gln Asp Xaa Val Ile Ile Ala Pro Pro Gln Tyr Val 
    450                 455                 460                 


Xaa Xaa Ser Ala Ser Asn Ile Val Ser Ala Xaa Ser Val Gln Asn Phe 
465                 470                 475                 480 


Gln Val Ala Xaa Gly Gln Met Val Xaa Ile Ala Gly Val Pro Ser Pro 
                485                 490                 495     


Gln Ala Ser Arg Val Gly Phe Gln Asn Ile Ala Pro Lys Pro Leu Pro 
            500                 505                 510         


Ser Gln Gln Val Ser Ser Xaa Val Val Gln Gln Pro Ile Gln Gln Pro 
        515                 520                 525             


Gln Gln Pro Xaa Gln Gln Ser Val Val Ile Val Ser Gln Pro Ala Gln 
    530                 535                 540                 


Gln Gly Gln Xaa Tyr Ala Pro Ala Ile His Gln Ile Val Leu Ala Asn 
545                 550                 555                 560 


Pro Ala Ala Leu Pro Ala Gly Gln Xaa Val Gln Leu Xaa Gly Gln Pro 
                565                 570                 575     


Asn Ile Xaa Pro Ser Ser Ser Pro Ser Pro Val Pro Ala Xaa Asn Asn 
            580                 585                 590         


Gln Val Pro Xaa Ala Met Ser Ser Ser Ser Xaa Pro Gln Ser Gln Gly 
        595                 600                 605             


Pro Pro Pro Xaa Val Ser Gln Met Leu Ser Val Lys Arg Gln Gln Gln 
    610                 615                 620                 


Gln Gln His Ser Pro Ala Pro Pro Pro Gln Gln Val Gln Val Gln Val 
625                 630                 635                 640 


Gln Gln Pro Gln Gln Val Gln Met Gln Val Gln Pro Gln Gln Ser Asn 
                645                 650                 655     


Ala Gly Val Gly Gln Pro Ala Ser Gly Glu Ser Ser Leu Ile Lys Gln 
            660                 665                 670         


Leu Leu Leu Pro Lys Arg Gly Pro Ser Xaa Pro Gly Gly Lys Leu Ile 
        675                 680                 685             


Leu Pro Ala Pro Gln Ile Pro Pro Pro Asn Asn Ala Arg Ala Pro Ser 
    690                 695                 700                 


Pro Gln Val Val Tyr Gln Val Ala Ser Asn Gln Ala Ala Gly Phe Gly 
705                 710                 715                 720 


Val Gln Gly Gln Xaa Pro Ala Gln Gln Leu Leu Val Gly Gln Gln Asn 
                725                 730                 735     


Val Gln Leu Val Pro Ser Ala Met Pro Pro Ser Gly Gly Val Gln Xaa 
            740                 745                 750         


Val Pro Ile Ser Asn Leu Gln Ile Leu Pro Gly Pro Leu Ile Ser Asn 
        755                 760                 765             


Ser Pro Ala Xaa Ile Phe Gln Gly Xaa Ser Gly Asn Gln Val Xaa Ile 
    770                 775                 780                 


Xaa Val Val Pro Asn Xaa Ser Phe Ala Pro Ala Xaa Val Ser Gln Gly 
785                 790                 795                 800 


Asn Ala Xaa Gln Leu Ile Ala Pro Ala Gly Ile Xaa Met Ser Gly Xaa 
                805                 810                 815     


Gln Xaa Gly Val Gly Leu Pro Val Gln Xaa Leu Pro Ala Xaa Gln Ala 
            820                 825                 830         


Ser Pro Ala Gly Gln Ser Ser Cys Xaa Xaa Ala Xaa Pro Pro Phe Lys 
        835                 840                 845             


Gly Asp Lys Ile Ile Cys Gln Lys Glu Glu Glu Ala Lys Glu Ala Xaa 
    850                 855                 860                 


Gly Leu His Val His Glu Arg Lys Ile Glu Val Met Glu Asn Pro Ser 
865                 870                 875                 880 


Cys Arg Arg Gly Ala Xaa Asn Xaa Ser Asn Gly Asp Xaa Lys Glu Asn 
                885                 890                 895     


Glu Met His Val Gly Ser Leu Leu Asn Gly Arg Lys Tyr Ser Asp Ser 
            900                 905                 910         


Ser Leu Pro Pro Ser Asn Ser Gly Lys Ile Gln Ser Glu Xaa Asn Gln 
        915                 920                 925             


Cys Ser Leu Ile Ser Asn Gly Pro Ser Leu Glu Leu Gly Glu Asn Gly 
    930                 935                 940                 


Ala Ser Gly Lys Gln Asn Ser Glu Gln Ile Asp Met Gln Asp Ile Lys 
945                 950                 955                 960 


Ser Asp Leu Arg Lys Pro Leu Val Asn Gly Ile Cys Asp Phe Asp Lys 
                965                 970                 975     


Gly Asp Gly Ser His Leu Ser Lys Asn Ile Pro Asn His Lys Xaa Ser 
            980                 985                 990         


Asn His Val Gly Asn Gly Glu Ile  Ser Pro Met Glu Pro  Gln Gly Xaa 
        995                 1000                 1005             


Leu Asp  Ile Xaa Gln Gln Asp  Xaa Ala Lys Gly Asp  Gln Leu Glu 
    1010                 1015                 1020             


Arg Ile  Ser Asn Gly Pro Val  Leu Xaa Leu Gly Gly  Ser Ser Val 
    1025                 1030                 1035             


Ser Ser  Ile Gln Glu Ala Ser  Asn Ala Ala Xaa Gln  Gln Phe Ser 
    1040                 1045                 1050             


Gly Xaa  Asp Leu Leu Asn Gly  Pro Leu Ala Ser Ser  Leu Asn Ser 
    1055                 1060                 1065             


Asp Val  Pro Gln Gln Arg Pro  Ser Val Val Val Ser  Pro His Ser 
    1070                 1075                 1080             


Xaa Xaa  Ser Val Ile Gln Gly  His Gln Ile Ile Ala  Val Pro Asp 
    1085                 1090                 1095             


Ser Gly  Ser Lys Val Ser His  Ser Pro Ala Leu Ser  Ser Asp Val 
    1100                 1105                 1110             


Arg Ser  Xaa Asn Gly Xaa Ala  Glu Cys Lys Xaa Val  Lys Arg Pro 
    1115                 1120                 1125             


Ala Glu  Asp Xaa Asp Arg Glu  Xaa Val Ala Gly Ile  Pro Asn Lys 
    1130                 1135                 1140             


Val Gly  Val Arg Ile Val Xaa  Ile Ser Asp Pro Asn  Asn Ala Gly 
    1145                 1150                 1155             


Cys Ser  Ala Xaa Met Val Ala  Val Pro Ala Gly Ala  Asp Pro Ser 
    1160                 1165                 1170             


Xaa Val  Ala Lys Val Ala Ile  Glu Ser Ala Val Gln  Gln Lys Gln 
    1175                 1180                 1185             


Gln His  Pro Pro Xaa Tyr Val  Gln Asn Val Val Pro  Gln Asn Xaa 
    1190                 1195                 1200             


Pro Met  Pro Pro Ser Pro Ala  Val Gln Val Gln Gly  Gln Pro Asn 
    1205                 1210                 1215             


Ser Ser  Gln Pro Ser Pro Phe  Ser Gly Ser Ser Gln  Pro Gly Asp 
    1220                 1225                 1230             


Pro Met  Arg Lys Pro Gly Gln  Asn Phe Met Cys Leu  Trp Gln Ser 
    1235                 1240                 1245             


Cys Lys  Lys Trp Phe Gln Xaa  Pro Ser Gln Val Phe  Tyr His Ala 
    1250                 1255                 1260             


Ala Xaa  Glu His Gly Gly Lys  Asp Val Tyr Pro Gly  Gln Cys Leu 
    1265                 1270                 1275             


Trp Glu  Gly Cys Glu Pro Phe  Gln Arg Gln Arg Phe  Ser Phe Ile 
    1280                 1285                 1290             


Xaa His  Leu Gln Asp Lys His  Cys Ser Lys Asp Ala  Leu Leu Ala 
    1295                 1300                 1305             


Gly Leu  Lys Gln Asp Glu Pro  Gly Gln Ala Gly Ser  Gln Lys Ser 
    1310                 1315                 1320             


Ser Xaa  Lys Gln Pro Xaa Val  Gly Gly Xaa Ser Ser  Xaa Pro Arg 
    1325                 1330                 1335             


Ala Gln  Lys Ala Ile Val Asn  His Pro Ser Ala Ala  Leu Met Ala 
    1340                 1345                 1350             


Leu Arg  Arg Gly Ser Arg Asn  Leu Val Phe Arg Asp  Phe Xaa Asp 
    1355                 1360                 1365             


Glu Lys  Glu Gly Pro Ile Xaa  Lys His Ile Arg Leu  Xaa Ala Ala 
    1370                 1375                 1380             


Leu Ile  Leu Lys Asn Ile Gly  Lys Tyr Ser Glu Cys  Gly Arg Arg 
    1385                 1390                 1395             


Leu Leu  Lys Arg His Glu Asn  Asn Leu Ser Val Leu  Ala Ile Ser 
    1400                 1405                 1410             


Asn Met  Glu Ala Ser Ser Xaa  Leu Ala Lys Cys Leu  Tyr Glu Leu 
    1415                 1420                 1425             


Asn Phe  Xaa Val Gln Ser Lys  Glu Gln Glu Lys Asp  Ser Glu Met 
    1430                 1435                 1440             


Leu Gln  
    1445 


<210> 3126
<211> 64
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<400> 3126
Xaa Gly Leu Lys Gln Asp Glu Pro Gly Gln Ala Gly Ser Gln Lys Ser 
1               5                   10                  15      


Ser Xaa Lys Gln Pro Xaa Val Gly Gly Xaa Ser Ser Xaa Pro Arg Ala 
            20                  25                  30          


Gln Lys Ala Ile Val Asn His Pro Ser Ala Ala Leu Met Ala Leu Arg 
        35                  40                  45              


Arg Gly Ser Arg Asn Leu Val Phe Arg Asp Phe Xaa Val Ser Met Pro 
    50                  55                  60                  


<210> 3127
<211> 339
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<400> 3127
Glu Asp Glu Glu Gly Leu Gly Pro Pro Gly Pro Ala Ser Leu Gly Xaa 
1               5                   10                  15      


Xaa Ala Leu Phe Pro Arg Lys Ala Gln Pro Pro Gln Ala Phe Arg Gly 
            20                  25                  30          


Asp Gly Val Pro Arg Val Leu Gly Gly Gln Glu Arg Pro Gly Pro Gly 
        35                  40                  45              


Pro Ala His Pro Gly Gly Ala Ala His Val Ala Pro Gln Leu Gln Pro 
    50                  55                  60                  


Pro Asp His Gly Asp Trp Xaa Tyr Glu Glu Gln Phe Lys Gln Leu Tyr 
65                  70                  75                  80  


Glu Leu Asp Gly Asp Pro Lys Arg Lys Glu Phe Leu Asp Asp Leu Phe 
                85                  90                  95      


Ser Phe Met Gln Lys Arg Gly Xaa Pro Val Asn Arg Ile Pro Ile Met 
            100                 105                 110         


Ala Lys Gln Val Leu Asp Leu Phe Met Leu Tyr Val Leu Val Xaa Glu 
        115                 120                 125             


Lys Gly Gly Leu Val Glu Val Ile Asn Lys Lys Leu Trp Arg Glu Ile 
    130                 135                 140                 


Xaa Lys Gly Leu Asn Leu Pro Xaa Ser Ile Xaa Ser Ala Ala Phe Xaa 
145                 150                 155                 160 


Leu Arg Xaa Gln Tyr Met Lys Tyr Leu Tyr Pro Tyr Glu Cys Glu Lys 
                165                 170                 175     


Arg Gly Leu Ser Asn Pro Asn Glu Leu Gln Ala Ala Ile Asp Ser Asn 
            180                 185                 190         


Arg Arg Glu Gly Arg Arg Gln Ser Phe Gly Gly Ser Leu Phe Ala Tyr 
        195                 200                 205             


Ser Pro Gly Gly Ala His Gly Met Leu Ser Ser Pro Lys Leu Pro Val 
    210                 215                 220                 


Ser Ser Leu Gly Leu Ala Ala Ser Xaa Asn Gly Ser Ser Ile Xaa Pro 
225                 230                 235                 240 


Ala Pro Lys Ile Lys Lys Ala Ser Glu Ser Arg Gln Asp Ser Ala Val 
                245                 250                 255     


Asn Leu Xaa Gly Xaa Asn Gly Ser Asn Ser Ile Ser Met Ser Val Glu 
            260                 265                 270         


Ile Asn Gly Ile Met Tyr Xaa Gly Val Leu Phe Ala Gln Pro Pro Ala 
        275                 280                 285             


Pro Xaa Pro Xaa Ser Ala Pro Asn Lys Gly Gly Gly Gly Gly Gly Gly 
    290                 295                 300                 


Ser Ser Ser Asn Ala Gly Gly Arg Gly Gly Asn Xaa Gly Xaa Ser Gly 
305                 310                 315                 320 


Gly Gln Ala Gly Pro Ala Gly Leu Ser Xaa Pro Ser Xaa Ser Xaa Ser 
                325                 330                 335     


Asn Asn Ser 
            


<210> 3128
<211> 593
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<400> 3128
Met Lys Leu Gln Ala Val Met Glu Xaa Leu Leu Gln Arg Gln Gln Arg 
1               5                   10                  15      


Ala Arg Gln Glu Leu Glu Ala Arg Gln Gln Leu Pro Pro Asp Pro Pro 
            20                  25                  30          


Ala Ala Pro Pro Gly Arg Ala Arg Ala Ala Pro Asp Glu Asp Arg Glu 
        35                  40                  45              


Pro Glu Ser Ala Arg Met Gln Arg Ala Gln Met Ala Ala Leu Ala Ala 
    50                  55                  60                  


Met Arg Ala Ala Ala Ala Gly Leu Gly His Pro Ala Ser Pro Gly Gly 
65                  70                  75                  80  


Ser Glu Asp Gly Pro Pro Gly Ser Glu Glu Glu Asp Ala Ala Arg Glu 
                85                  90                  95      


Gly Xaa Pro Gly Ser Pro Gly Arg Gly Arg Glu Gly Pro Gly Glu Glu 
            100                 105                 110         


His Phe Glu Asp Met Ala Ser Asp Glu Asp Met Lys Pro Lys Trp Glu 
        115                 120                 125             


Glu Glu Glu Met Glu Glu Asp Leu Gly Glu Asp Glu Glu Glu Glu Glu 
    130                 135                 140                 


Glu Asp Tyr Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Gly Leu Gly 
145                 150                 155                 160 


Pro Pro Gly Pro Ala Ser Leu Gly Xaa Xaa Ala Leu Phe Pro Arg Lys 
                165                 170                 175     


Ala Gln Pro Pro Gln Ala Phe Arg Gly Asp Gly Val Pro Arg Val Leu 
            180                 185                 190         


Gly Gly Gln Glu Arg Pro Gly Pro Gly Pro Ala His Pro Gly Gly Ala 
        195                 200                 205             


Ala His Val Ala Pro Gln Leu Gln Pro Pro Asp His Gly Asp Trp Xaa 
    210                 215                 220                 


Tyr Glu Glu Gln Phe Lys Gln Leu Tyr Glu Leu Asp Gly Asp Pro Lys 
225                 230                 235                 240 


Arg Lys Glu Phe Leu Asp Asp Leu Phe Ser Phe Met Gln Lys Arg Gly 
                245                 250                 255     


Xaa Pro Val Asn Arg Ile Pro Ile Met Ala Lys Gln Val Leu Asp Leu 
            260                 265                 270         


Phe Met Leu Tyr Val Leu Val Xaa Glu Lys Gly Gly Leu Val Glu Val 
        275                 280                 285             


Ile Asn Lys Lys Leu Trp Arg Glu Ile Xaa Lys Gly Leu Asn Leu Pro 
    290                 295                 300                 


Xaa Ser Ile Xaa Ser Ala Ala Phe Xaa Leu Arg Xaa Gln Tyr Met Lys 
305                 310                 315                 320 


Tyr Leu Tyr Pro Tyr Glu Cys Glu Lys Arg Gly Leu Ser Asn Pro Asn 
                325                 330                 335     


Glu Leu Gln Ala Ala Ile Asp Ser Asn Arg Arg Glu Gly Arg Arg Gln 
            340                 345                 350         


Ser Phe Gly Gly Ser Leu Phe Ala Tyr Ser Pro Gly Gly Ala His Gly 
        355                 360                 365             


Met Leu Ser Ser Pro Lys Leu Pro Val Ser Ser Leu Gly Leu Ala Ala 
    370                 375                 380                 


Ser Xaa Asn Gly Ser Ser Ile Xaa Pro Ala Pro Lys Ile Lys Lys Glu 
385                 390                 395                 400 


Glu Asp Ser Ala Ile Pro Ile Xaa Val Pro Gly Arg Leu Pro Val Ser 
                405                 410                 415     


Leu Ala Gly His Pro Val Val Ala Ala Gln Ala Ala Ala Val Gln Ala 
            420                 425                 430         


Ala Ala Ala Gln Ala Ala Val Ala Ala Gln Ala Ala Ala Leu Glu Gln 
        435                 440                 445             


Leu Arg Glu Lys Leu Glu Ser Ala Glu Pro Pro Glu Lys Lys Met Ala 
    450                 455                 460                 


Leu Val Ala Asp Glu Gln Gln Arg Leu Met Gln Arg Ala Leu Gln Gln 
465                 470                 475                 480 


Asn Phe Leu Ala Met Ala Ala Gln Leu Pro Met Ser Ile Arg Ile Asn 
                485                 490                 495     


Ser Gln Ala Ser Glu Ser Arg Gln Asp Ser Ala Val Asn Leu Xaa Gly 
            500                 505                 510         


Xaa Asn Gly Ser Asn Ser Ile Ser Met Ser Val Glu Ile Asn Gly Ile 
        515                 520                 525             


Met Tyr Xaa Gly Val Leu Phe Ala Gln Pro Pro Ala Pro Xaa Pro Xaa 
    530                 535                 540                 


Ser Ala Pro Asn Lys Gly Gly Gly Gly Gly Gly Gly Ser Ser Ser Asn 
545                 550                 555                 560 


Ala Gly Gly Arg Gly Gly Asn Xaa Gly Xaa Ser Gly Gly Gln Ala Gly 
                565                 570                 575     


Pro Ala Gly Leu Ser Xaa Pro Ser Xaa Ser Xaa Ser Asn Asn Ser Leu 
            580                 585                 590         


Pro 
    


<210> 3129
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 3129
Xaa Phe Pro Arg Lys Ala Gln Pro Pro Gln Ala Phe Arg Gly Asp Gly 
1               5                   10                  15      


Val Pro Arg Val Leu Gly Gly Gln Glu Arg Pro Gly Pro Gly Pro Ala 
            20                  25                  30          


His Pro Gly Gly Ala Ala His Val Ala Pro Gln Leu Gln Pro Pro Asp 
        35                  40                  45              


His Gly Asp Trp Xaa Tyr Glu Glu Gln Phe Lys Gln Leu Tyr Glu Leu 
    50                  55                  60                  


Asp Gly Asp Pro Lys Arg Lys Glu Phe Leu Asp Asp Leu Phe Ser Phe 
65                  70                  75                  80  


Met Gln Lys Arg Val Gln Lys Leu Xaa Arg Arg Gly Gly Arg Arg Leu 
                85                  90                  95      


<210> 3130
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<400> 3130
Met Ala Lys Gln Ile Leu Asp Leu Tyr Met Leu Tyr Lys Leu Val Xaa 
1               5                   10                  15      


Glu Lys Gly Gly Leu Val Glu Ile Ile Asn Lys Lys Ile Trp Arg Glu 
            20                  25                  30          


Ile Xaa Lys Gly Leu Asn Leu Pro Xaa Ser Ile Xaa Ser Ala Ala Phe 
        35                  40                  45              


Xaa Leu Arg Xaa Gln Tyr Met Lys Tyr Leu Tyr Ala Tyr Glu Cys Glu 
    50                  55                  60                  


Lys Lys Ala Leu Ser Ser Pro Ala Glu Leu Gln Ala Ala Ile Asp Gly 
65                  70                  75                  80  


Asn Arg Arg Glu Gly Arg Arg Pro Ser Tyr Ser Ser Ser Leu Phe Gly 
                85                  90                  95      


Tyr Ser Pro Ala Ala Ala Xaa Ala Ala Ala Ala Ala Gly Ala Pro Ala 
            100                 105                 110         


Leu Leu Ser Pro Pro Lys Ile Arg Phe Pro Ile Leu Gly Leu Gly Ser 
        115                 120                 125             


Ser Ser Gly Xaa Asn Xaa Ser Ser Pro Arg 
    130                 135             


<210> 3131
<211> 560
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<400> 3131
Met Glu Pro Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Lys 
1               5                   10                  15      


Gln Pro His Leu Ala Pro Leu Gln Met Asp Ala Arg Glu Lys Gln Gly 
            20                  25                  30          


Gln Gln Met Arg Glu Ala Gln Phe Leu Tyr Ala Gln Lys Leu Val Xaa 
        35                  40                  45              


Gln Pro Xaa Leu Leu Ser Ala Xaa Ala Gly Arg Pro Ser Gly Ser Xaa 
    50                  55                  60                  


Pro Leu Gly Pro Leu Ala Arg Val Pro Pro Xaa Ala Ala Val Ala Gln 
65                  70                  75                  80  


Val Phe Glu Arg Gly Asn Met Asn Ser Glu Pro Glu Glu Glu Asp Gly 
                85                  90                  95      


Gly Leu Glu Asp Glu Asp Gly Asp Asp Glu Val Ala Glu Val Ala Glu 
            100                 105                 110         


Lys Glu Xaa Gln Ala Ala Ser Lys Tyr Phe His Val Gln Lys Val Ala 
        115                 120                 125             


Arg Gln Asp Pro Arg Val Ala Pro Met Ser Asn Leu Leu Pro Ala Pro 
    130                 135                 140                 


Gly Leu Pro Pro His Gly Gln Gln Ala Lys Glu Asp His Xaa Lys Asp 
145                 150                 155                 160 


Ala Ser Lys Ala Ser Pro Ser Val Ser Xaa Ala Gly Gln Pro Asn Trp 
                165                 170                 175     


Asn Leu Asp Glu Gln Leu Lys Gln Asn Gly Gly Leu Ala Trp Ser Asp 
            180                 185                 190         


Asp Ala Asp Gly Gly Arg Gly Arg Glu Ile Ser Arg Asp Phe Ala Lys 
        195                 200                 205             


Leu Tyr Glu Leu Asp Gly Asp Pro Glu Arg Lys Glu Phe Leu Asp Asp 
    210                 215                 220                 


Leu Phe Val Phe Met Gln Lys Arg Gly Xaa Pro Ile Asn Arg Ile Pro 
225                 230                 235                 240 


Ile Met Ala Lys Gln Ile Leu Asp Leu Tyr Met Leu Tyr Lys Leu Val 
                245                 250                 255     


Xaa Glu Lys Gly Gly Leu Val Glu Ile Ile Asn Lys Lys Ile Trp Arg 
            260                 265                 270         


Glu Ile Xaa Lys Gly Leu Asn Leu Pro Xaa Ser Ile Xaa Ser Ala Ala 
        275                 280                 285             


Phe Xaa Leu Arg Xaa Gln Tyr Met Lys Tyr Leu Tyr Ala Tyr Glu Cys 
    290                 295                 300                 


Glu Lys Lys Ala Leu Ser Ser Pro Ala Glu Leu Gln Ala Ala Ile Asp 
305                 310                 315                 320 


Gly Asn Arg Arg Glu Gly Arg Arg Pro Ser Tyr Ser Ser Ser Leu Phe 
                325                 330                 335     


Gly Tyr Ser Pro Ala Ala Ala Xaa Ala Ala Ala Ala Ala Gly Ala Pro 
            340                 345                 350         


Ala Leu Leu Ser Pro Pro Lys Ile Arg Phe Pro Ile Leu Gly Leu Gly 
        355                 360                 365             


Ser Ser Ser Gly Xaa Asn Xaa Ser Ser Pro Arg Ile Ser Pro Ala Xaa 
    370                 375                 380                 


Xaa Leu Arg Lys Gly Asp Gly Ala Pro Val Xaa Xaa Val Pro Val Pro 
385                 390                 395                 400 


Asn Arg Leu Ala Val Pro Val Xaa Leu Ala Ser Gln Gln Ala Gly Xaa 
                405                 410                 415     


Arg Xaa Ala Ala Leu Glu Gln Leu Arg Glu Arg Leu Glu Ser Gly Glu 
            420                 425                 430         


Pro Ala Glu Lys Lys Ala Ser Arg Leu Ser Glu Glu Glu Gln Arg Leu 
        435                 440                 445             


Val Gln Gln Ala Phe Gln Arg Asn Phe Phe Ser Met Ala Arg Gln Leu 
    450                 455                 460                 


Pro Met Lys Ile Arg Ile Asn Gly Arg Glu Asp Arg Ala Glu Ala Ser 
465                 470                 475                 480 


Ala Ala Ala Leu Asn Leu Xaa Xaa Ser Ser Ile Gly Ser Ile Asn Met 
                485                 490                 495     


Ser Val Asp Ile Asp Gly Xaa Xaa Tyr Ala Gly Val Leu Phe Ala Gln 
            500                 505                 510         


Lys Pro Val Val His Leu Ile Xaa Gly Ser Ala Pro Gln Ser Leu Gly 
        515                 520                 525             


Ser Ser Ala Ser Ser Ser Ser Ser Ser His Cys Ser Pro Ser Pro Xaa 
    530                 535                 540                 


Ser Ser Arg Gly Xaa Pro Ser Ala Glu Pro Ser Xaa Ser Trp Ser Leu 
545                 550                 555                 560 


<210> 3132
<211> 561
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<400> 3132
Met Glu Pro Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Lys 
1               5                   10                  15      


Gln Pro His Leu Ala Pro Leu Gln Met Asp Ala Arg Glu Lys Gln Gly 
            20                  25                  30          


Gln Gln Met Arg Glu Ala Gln Phe Leu Tyr Ala Gln Lys Leu Val Xaa 
        35                  40                  45              


Gln Pro Xaa Leu Leu Ser Ala Xaa Ala Gly Arg Pro Ser Gly Ser Xaa 
    50                  55                  60                  


Pro Leu Gly Pro Leu Ala Arg Val Pro Pro Xaa Ala Ala Val Ala Gln 
65                  70                  75                  80  


Val Phe Glu Arg Gly Asn Met Asn Ser Glu Pro Glu Glu Glu Asp Gly 
                85                  90                  95      


Gly Leu Glu Asp Glu Asp Gly Asp Asp Glu Val Ala Glu Val Ala Glu 
            100                 105                 110         


Lys Glu Xaa Gln Ala Ala Ser Lys Tyr Phe His Val Gln Lys Val Ala 
        115                 120                 125             


Arg Gln Asp Pro Arg Val Ala Pro Met Ser Asn Leu Leu Pro Ala Pro 
    130                 135                 140                 


Gly Leu Pro Pro His Gly Gln Gln Ala Lys Glu Asp His Xaa Lys Asp 
145                 150                 155                 160 


Ala Ser Lys Ala Ser Pro Ser Val Ser Xaa Ala Gly Gln Pro Asn Trp 
                165                 170                 175     


Asn Leu Asp Glu Gln Leu Lys Gln Asn Gly Gly Leu Ala Trp Ser Asp 
            180                 185                 190         


Asp Ala Asp Gly Gly Arg Gly Arg Glu Ile Ser Arg Asp Phe Ala Lys 
        195                 200                 205             


Leu Tyr Glu Leu Asp Gly Asp Pro Glu Arg Lys Glu Phe Leu Asp Asp 
    210                 215                 220                 


Leu Phe Val Phe Met Gln Lys Arg Gly Xaa Pro Ile Asn Arg Ile Pro 
225                 230                 235                 240 


Ile Met Ala Lys Gln Ile Leu Asp Leu Tyr Met Leu Tyr Lys Leu Val 
                245                 250                 255     


Xaa Glu Lys Gly Gly Leu Val Glu Ile Ile Asn Lys Lys Ile Trp Arg 
            260                 265                 270         


Glu Ile Xaa Lys Gly Leu Asn Leu Pro Xaa Ser Ile Xaa Ser Ala Ala 
        275                 280                 285             


Phe Xaa Leu Arg Xaa Gln Tyr Met Lys Tyr Leu Tyr Ala Tyr Glu Cys 
    290                 295                 300                 


Glu Lys Lys Ala Leu Ser Ser Pro Ala Glu Leu Gln Ala Ala Ile Asp 
305                 310                 315                 320 


Gly Asn Arg Arg Glu Gly Arg Arg Pro Ser Tyr Ser Ser Ser Leu Phe 
                325                 330                 335     


Gly Tyr Ser Pro Ala Ala Ala Xaa Ala Ala Ala Ala Ala Gly Ala Pro 
            340                 345                 350         


Ala Leu Leu Ser Pro Pro Lys Ile Arg Phe Pro Ile Leu Gly Leu Gly 
        355                 360                 365             


Ser Ser Ser Gly Xaa Asn Xaa Ser Ser Pro Arg Ile Ser Pro Ala Xaa 
    370                 375                 380                 


Xaa Leu Arg Lys Gly Asp Gly Ala Pro Val Xaa Xaa Val Pro Val Pro 
385                 390                 395                 400 


Asn Arg Leu Ala Val Pro Val Xaa Leu Ala Ser Gln Gln Ala Gly Xaa 
                405                 410                 415     


Arg Xaa Ala Ala Leu Glu Gln Leu Arg Glu Arg Leu Glu Ser Gly Glu 
            420                 425                 430         


Pro Ala Glu Lys Lys Ala Ser Arg Leu Ser Glu Glu Glu Gln Arg Leu 
        435                 440                 445             


Val Gln Gln Ala Phe Gln Arg Asn Phe Phe Ser Met Ala Arg Gln Leu 
    450                 455                 460                 


Pro Met Lys Ile Arg Ile Asn Gly Arg Ala Glu Asp Arg Ala Glu Ala 
465                 470                 475                 480 


Ser Ala Ala Ala Leu Asn Leu Xaa Xaa Ser Ser Ile Gly Ser Ile Asn 
                485                 490                 495     


Met Ser Val Asp Ile Asp Gly Xaa Xaa Tyr Ala Gly Val Leu Phe Ala 
            500                 505                 510         


Gln Lys Pro Val Val His Leu Ile Xaa Gly Ser Ala Pro Gln Ser Leu 
        515                 520                 525             


Gly Ser Ser Ala Ser Ser Ser Ser Ser Ser His Cys Ser Pro Ser Pro 
    530                 535                 540                 


Xaa Ser Ser Arg Gly Xaa Pro Ser Ala Glu Pro Ser Xaa Ser Trp Ser 
545                 550                 555                 560 


Leu 
    


<210> 3133
<211> 412
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<400> 3133
Met Glu Ala Leu Gln Lys Gln Gln Ala Ala Arg Leu Ala Gln Gly Val 
1               5                   10                  15      


Gly Pro Leu Ala Pro Ala Cys Pro Leu Leu Pro Pro Gln Pro Pro Leu 
            20                  25                  30          


Pro Asp His Arg Xaa Leu Gln Ala Pro Glu Gly Ala Leu Gly Asn Val 
        35                  40                  45              


Gly Ala Glu Glu Glu Glu Asp Ala Glu Glu Asp Glu Glu Lys Arg Glu 
    50                  55                  60                  


Glu Ala Gly Ala Glu Glu Glu Ala Ala Glu Glu Ser Arg Pro Gly Ala 
65                  70                  75                  80  


Gln Gly Pro Ser Ser Pro Ser Ser Gln Pro Pro Gly Leu His Pro His 
                85                  90                  95      


Glu Trp Xaa Tyr Glu Glu Gln Phe Lys Gln Leu Tyr Glu Leu Asp Ala 
            100                 105                 110         


Asp Pro Lys Arg Lys Glu Phe Leu Asp Asp Leu Phe Ser Phe Met Gln 
        115                 120                 125             


Lys Arg Gly Xaa Pro Val Asn Arg Val Pro Ile Met Ala Lys Gln Val 
    130                 135                 140                 


Leu Asp Leu Tyr Ala Leu Phe Arg Leu Val Xaa Ala Lys Gly Gly Leu 
145                 150                 155                 160 


Val Glu Val Ile Asn Arg Lys Val Trp Arg Glu Val Xaa Arg Gly Leu 
                165                 170                 175     


Ser Leu Pro Xaa Xaa Ile Xaa Ser Ala Ala Phe Xaa Leu Arg Xaa Gln 
            180                 185                 190         


Tyr Met Lys Tyr Leu Tyr Pro Tyr Glu Cys Glu Xaa Arg Ala Leu Ser 
        195                 200                 205             


Ser Pro Gly Glu Leu Gln Ala Ala Ile Asp Ser Asn Arg Arg Glu Gly 
    210                 215                 220                 


Arg Arg Gln Ala Tyr Xaa Ala Xaa Pro Leu Phe Gly Leu Ala Gly Pro 
225                 230                 235                 240 


Pro Pro Arg Gly Ala Gln Asp Pro Ala Leu Gly Pro Gly Pro Ala Pro 
                245                 250                 255     


Pro Ala Xaa Gln Ser Ser Pro Gly Pro Ala Gln Gly Ser Xaa Ser Gly 
            260                 265                 270         


Leu Pro Ala His Ala Cys Ala Gln Leu Ser Pro Ser Pro Ile Lys Lys 
        275                 280                 285             


Glu Glu Ser Gly Ile Pro Asn Pro Cys Leu Ala Leu Pro Val Gly Leu 
    290                 295                 300                 


Ala Leu Gly Pro Xaa Arg Glu Lys Leu Ala Pro Glu Glu Pro Pro Glu 
305                 310                 315                 320 


Lys Arg Ala Val Leu Met Gly Pro Met Asp Pro Pro Arg Pro Cys Met 
                325                 330                 335     


Pro Pro Ser Phe Leu Pro Arg Gly Lys Val Pro Leu Arg Glu Glu Arg 
            340                 345                 350         


Leu Asp Gly Pro Leu Asn Leu Ala Gly Ser Gly Ile Ser Ser Ile Asn 
        355                 360                 365             


Met Ala Leu Glu Ile Asn Gly Val Val Tyr Xaa Gly Val Leu Phe Ala 
    370                 375                 380                 


Arg Arg Gln Pro Val Pro Ala Ser Gln Gly Pro Xaa Asn Pro Ala Pro 
385                 390                 395                 400 


Pro Pro Ser Xaa Gly Pro Pro Ser Ser Ile Leu Pro 
                405                 410         


<210> 3134
<211> 748
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<400> 3134
Met Glu Asp Arg Gly Xaa Pro Ile Asn Lys Pro Pro Val Leu Gly Tyr 
1               5                   10                  15      


Lys Asp Leu Asn Leu Phe Lys Leu Phe Arg Leu Val Tyr His Gln Gly 
            20                  25                  30          


Gly Cys Asp Asn Ile Asp Ser Gly Ala Val Trp Lys Gln Ile Tyr Met 
        35                  40                  45              


Asp Leu Gly Ile Pro Ile Leu Asn Ser Ala Ala Ser Tyr Asn Val Lys 
    50                  55                  60                  


Xaa Ala Tyr Arg Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys Arg Ser 
65                  70                  75                  80  


Ala Asn Ile Gln Phe Arg Xaa Val His His His Glu Pro Lys Val Lys 
                85                  90                  95      


Glu Glu Lys Lys Asp Leu Glu Glu Ser Met Glu Glu Ala Leu Lys Leu 
            100                 105                 110         


Asp Gln Glu Met Pro Leu Xaa Glu Val Lys Ser Glu Pro Glu Glu Asn 
        115                 120                 125             


Ile Asp Ser Asn Ser Glu Ser Glu Arg Glu Glu Ile Glu Leu Lys Ser 
    130                 135                 140                 


Pro Arg Gly Arg Arg Arg Ile Ala Arg Asp Val Asn Ser Ile Lys Lys 
145                 150                 155                 160 


Glu Ile Glu Glu Glu Lys Xaa Glu Asp Lys Leu Lys Asp Asn Asp Xaa 
                165                 170                 175     


Glu Asn Lys Asp Val Asp Asp Asp Tyr Glu Xaa Ala Glu Lys Lys Glu 
            180                 185                 190         


Asn Glu Leu Leu Leu Gly Arg Lys Asn Xaa Pro Lys Gln Lys Glu Lys 
        195                 200                 205             


Lys Ile Lys Lys Gln Glu Asp Ser Asp Lys Asp Ser Asp Glu Glu Glu 
    210                 215                 220                 


Glu Lys Ser Gln Glu Arg Glu Glu Xaa Glu Ser Lys Cys Asp Ser Glu 
225                 230                 235                 240 


Gly Glu Glu Asp Glu Glu Asp Met Glu Pro Cys Leu Xaa Gly Xaa Lys 
                245                 250                 255     


Val Lys Val Lys Tyr Gly Arg Gly Lys Xaa Gln Lys Ile Tyr Glu Ala 
            260                 265                 270         


Ser Ile Lys Ser Xaa Glu Ile Asp Asp Gly Glu Val Leu Tyr Leu Val 
        275                 280                 285             


His Tyr Tyr Gly Trp Asn Val Arg Tyr Asp Glu Trp Val Lys Ala Asp 
    290                 295                 300                 


Arg Ile Ile Trp Pro Leu Asp Lys Gly Gly Pro Lys Lys Lys Gln Lys 
305                 310                 315                 320 


Lys Lys Ala Lys Asn Lys Glu Asp Ser Glu Lys Asp Glu Lys Arg Asp 
                325                 330                 335     


Glu Glu Arg Gln Lys Ser Lys Arg Gly Arg Pro Pro Leu Lys Ser Xaa 
            340                 345                 350         


Leu Ser Ser Asn Met Pro Tyr Gly Leu Ser Lys Xaa Ala Asn Ser Glu 
        355                 360                 365             


Gly Lys Ser Asp Ser Cys Ser Ser Asp Ser Glu Xaa Glu Asp Ala Leu 
    370                 375                 380                 


Glu Lys Asn Leu Ile Asn Glu Glu Leu Ser Leu Lys Asp Glu Leu Glu 
385                 390                 395                 400 


Lys Asn Glu Asn Leu Asn Asp Asp Lys Leu Asp Glu Glu Asn Pro Lys 
                405                 410                 415     


Ile Ser Ala His Ile Leu Lys Glu Asn Asp Arg Xaa Gln Met Gln Pro 
            420                 425                 430         


Leu Glu Xaa Leu Lys Leu Glu Val Gly Glu Asn Glu Gln Ile Val Gln 
        435                 440                 445             


Ile Phe Gly Asn Lys Met Glu Lys Xaa Glu Glu Val Lys Lys Glu Ala 
    450                 455                 460                 


Glu Lys Ser Pro Lys Gly Lys Gly Arg Arg Ser Lys Xaa Lys Asp Leu 
465                 470                 475                 480 


Ser Leu Glu Ile Ile Lys Ile Ser Ser Phe Gly Gln Asn Glu Ala Gly 
                485                 490                 495     


Ser Glu Pro His Ile Glu Ala His Ser Leu Glu Leu Ser Ser Leu Asp 
            500                 505                 510         


Asn Lys Asn Phe Ser Ser Ala Xaa Glu Asp Glu Ile Asp Gln Cys Val 
        515                 520                 525             


Lys Glu Lys Lys Leu Lys Arg Lys Ile Leu Gly Gln Ser Ser Pro Glu 
    530                 535                 540                 


Lys Lys Ile Arg Ile Glu Asn Gly Met Glu Met Xaa Asn Xaa Val Ser 
545                 550                 555                 560 


Gln Glu Arg Xaa Ser Asp Cys Ile Gly Ser Glu Gly Met Lys Asn Leu 
                565                 570                 575     


Asn Phe Glu Gln His Phe Glu Arg Glu Asn Glu Gly Met Pro Ser Leu 
            580                 585                 590         


Ile Ala Glu Ser Asn Gln Cys Ile Gln Gln Leu Xaa Ser Glu Arg Phe 
        595                 600                 605             


Asp Ser Pro Ala Glu Glu Xaa Val Asn Ile Pro Leu Lys Glu Asp Glu 
    610                 615                 620                 


Asp Ala Met Pro Leu Ile Gly Pro Glu Xaa Leu Val Cys His Glu Val 
625                 630                 635                 640 


Asp Leu Asp Asp Leu Asp Glu Lys Asp Lys Xaa Ser Ile Glu Asp Val 
                645                 650                 655     


Ala Val Glu Ser Ser Glu Ser Asn Ser Leu Val Ser Ile Pro Pro Ala 
            660                 665                 670         


Leu Pro Pro Val Val Gln His Asn Phe Ser Val Ala Ser Pro Leu Xaa 
        675                 680                 685             


Leu Ser Gln Asp Glu Ser Arg Ser Val Lys Ser Glu Ser Asp Ile Xaa 
    690                 695                 700                 


Ile Glu Val Asp Ser Ile Ala Glu Glu Ser Gln Glu Gly Leu Cys Glu 
705                 710                 715                 720 


Arg Glu Ser Ala Asn Gly Phe Glu Xaa Asn Val Ala Ser Gly Xaa Cys 
                725                 730                 735     


Ser Ile Ile Val Gln Glu Arg Glu Ser Arg Glu Lys 
            740                 745             


<210> 3135
<211> 40
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<400> 3135
Met Lys Ala Ala Asp Glu Pro Ala Tyr Leu Xaa Val Gly Xaa Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Xaa Val 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Asn 
        35                  40  


<210> 3136
<211> 54
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(48)
<223> Selenocysteine

<400> 3136
Met Lys Ala Ala Asp Glu Pro Ala Tyr Leu Xaa Val Gly Xaa Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Xaa Val 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Leu Leu Lys Gln Asp Asn Xaa Xaa 
        35                  40                  45              


Gln Leu Val Gln Asp Asp 
    50                  


<210> 3137
<211> 1188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1105)..(1105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<400> 3137
Met Lys Ala Ala Asp Glu Pro Ala Tyr Leu Xaa Val Gly Xaa Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Xaa Val 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Leu Leu Lys Gln Asp Asn Xaa Xaa 
        35                  40                  45              


Gln Leu Val Gln Asp Asp Gln Val Lys Gly Pro Leu Arg Val Gly Ala 
    50                  55                  60                  


Ile Val Glu Xaa Arg Xaa Ser Asp Gly Ser Phe Gln Glu Ala Ile Ile 
65                  70                  75                  80  


Ser Lys Leu Xaa Asp Ala Ser Trp Tyr Xaa Val Val Phe Asp Asp Gly 
                85                  90                  95      


Asp Glu Arg Xaa Leu Arg Arg Xaa Ser Leu Cys Leu Lys Gly Glu Arg 
            100                 105                 110         


His Phe Ala Glu Ser Glu Xaa Leu Asp Gln Leu Pro Leu Xaa Asn Pro 
        115                 120                 125             


Glu His Phe Gly Xaa Pro Val Ile Ala Lys Lys Xaa Asn Arg Gly Arg 
    130                 135                 140                 


Arg Ser Ser Leu Pro Val Xaa Glu Asp Glu Lys Glu Glu Glu Ser Ser 
145                 150                 155                 160 


Glu Glu Glu Asp Glu Asp Lys Arg Arg Leu Asn Asp Glu Leu Leu Gly 
                165                 170                 175     


Lys Val Val Ser Val Val Ser Ala Xaa Glu Arg Xaa Glu Trp Tyr Pro 
            180                 185                 190         


Ala Leu Val Ile Ser Pro Ser Cys Asn Asp Asp Ile Xaa Val Lys Lys 
        195                 200                 205             


Asp Gln Cys Leu Val Arg Ser Phe Ile Asp Ser Lys Phe Tyr Ser Ile 
    210                 215                 220                 


Ala Arg Lys Asp Ile Lys Glu Val Asp Ile Leu Asn Leu Pro Glu Ser 
225                 230                 235                 240 


Glu Leu Ser Xaa Lys Pro Gly Leu Gln Lys Ala Ser Ile Phe Leu Lys 
                245                 250                 255     


Xaa Arg Val Val Pro Asp Asn Trp Lys Met Asp Ile Ser Glu Ile Leu 
            260                 265                 270         


Glu Ser Ser Ser Ser Asp Asp Glu Asp Gly Pro Ala Glu Glu Asn Asp 
        275                 280                 285             


Glu Glu Lys Glu Lys Glu Ala Lys Lys Xaa Glu Glu Glu Val Pro Glu 
    290                 295                 300                 


Glu Glu Leu Asp Pro Glu Glu Arg Asp Asn Phe Leu Gln Gln Leu Tyr 
305                 310                 315                 320 


Lys Phe Met Glu Asp Arg Gly Xaa Pro Ile Asn Lys Pro Pro Val Leu 
                325                 330                 335     


Gly Tyr Lys Asp Leu Asn Leu Phe Lys Leu Phe Arg Leu Val Tyr His 
            340                 345                 350         


Gln Gly Gly Cys Asp Asn Ile Asp Ser Gly Ala Val Trp Lys Gln Ile 
        355                 360                 365             


Tyr Met Asp Leu Gly Ile Pro Ile Leu Asn Ser Ala Ala Ser Tyr Asn 
    370                 375                 380                 


Val Lys Xaa Ala Tyr Arg Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys 
385                 390                 395                 400 


Arg Ser Ala Asn Ile Gln Phe Arg Xaa Val His His His Glu Pro Lys 
                405                 410                 415     


Val Lys Glu Glu Lys Lys Asp Leu Glu Glu Ser Met Glu Glu Ala Leu 
            420                 425                 430         


Lys Leu Asp Gln Glu Met Pro Leu Xaa Glu Val Lys Ser Glu Pro Glu 
        435                 440                 445             


Glu Asn Ile Asp Ser Asn Ser Glu Ser Glu Arg Glu Glu Ile Glu Leu 
    450                 455                 460                 


Lys Ser Pro Arg Gly Arg Arg Arg Ile Ala Arg Asp Val Asn Ser Ile 
465                 470                 475                 480 


Lys Lys Glu Ile Glu Glu Glu Lys Xaa Glu Asp Lys Leu Lys Asp Asn 
                485                 490                 495     


Asp Xaa Glu Asn Lys Asp Val Asp Asp Asp Tyr Glu Xaa Ala Glu Lys 
            500                 505                 510         


Lys Glu Asn Glu Leu Leu Leu Gly Arg Lys Asn Xaa Pro Lys Gln Lys 
        515                 520                 525             


Glu Lys Lys Ile Lys Lys Gln Glu Asp Ser Asp Lys Asp Ser Asp Glu 
    530                 535                 540                 


Glu Glu Glu Lys Ser Gln Glu Arg Glu Glu Xaa Glu Ser Lys Cys Asp 
545                 550                 555                 560 


Ser Glu Gly Glu Glu Asp Glu Glu Asp Met Glu Pro Cys Leu Xaa Gly 
                565                 570                 575     


Xaa Lys Val Lys Val Lys Tyr Gly Arg Gly Lys Xaa Gln Lys Ile Tyr 
            580                 585                 590         


Glu Ala Ser Ile Lys Ser Xaa Glu Ile Asp Asp Gly Glu Val Leu Tyr 
        595                 600                 605             


Leu Val His Tyr Tyr Gly Trp Asn Val Arg Tyr Asp Glu Trp Val Lys 
    610                 615                 620                 


Ala Asp Arg Ile Ile Trp Pro Leu Asp Lys Gly Gly Pro Lys Lys Lys 
625                 630                 635                 640 


Gln Lys Lys Lys Ala Lys Asn Lys Glu Asp Ser Glu Lys Asp Glu Lys 
                645                 650                 655     


Arg Asp Glu Glu Arg Gln Lys Ser Lys Arg Gly Arg Pro Pro Leu Lys 
            660                 665                 670         


Ser Xaa Leu Ser Ser Asn Met Pro Tyr Gly Leu Ser Lys Xaa Ala Asn 
        675                 680                 685             


Ser Glu Gly Lys Ser Asp Ser Cys Ser Ser Asp Ser Glu Xaa Glu Asp 
    690                 695                 700                 


Ala Leu Glu Lys Asn Leu Ile Asn Glu Glu Leu Ser Leu Lys Asp Glu 
705                 710                 715                 720 


Leu Glu Lys Asn Glu Asn Leu Asn Asp Asp Lys Leu Asp Glu Glu Asn 
                725                 730                 735     


Pro Lys Ile Ser Ala His Ile Leu Lys Glu Asn Asp Arg Xaa Gln Met 
            740                 745                 750         


Gln Pro Leu Glu Xaa Leu Lys Leu Glu Val Gly Glu Asn Glu Gln Ile 
        755                 760                 765             


Val Gln Ile Phe Gly Asn Lys Met Glu Lys Xaa Glu Glu Val Lys Lys 
    770                 775                 780                 


Glu Ala Glu Lys Ser Pro Lys Gly Lys Gly Arg Arg Ser Lys Xaa Lys 
785                 790                 795                 800 


Asp Leu Ser Leu Glu Ile Ile Lys Ile Ser Ser Phe Gly Gln Asn Glu 
                805                 810                 815     


Ala Gly Ser Glu Pro His Ile Glu Ala His Ser Leu Glu Leu Ser Ser 
            820                 825                 830         


Leu Asp Asn Lys Asn Phe Ser Ser Ala Xaa Glu Asp Glu Ile Asp Gln 
        835                 840                 845             


Cys Val Lys Glu Lys Lys Leu Lys Arg Lys Ile Leu Gly Gln Ser Ser 
    850                 855                 860                 


Pro Glu Lys Lys Ile Arg Ile Glu Asn Gly Met Glu Met Xaa Asn Xaa 
865                 870                 875                 880 


Val Ser Gln Glu Arg Xaa Ser Asp Cys Ile Gly Ser Glu Gly Met Lys 
                885                 890                 895     


Asn Leu Asn Phe Glu Gln His Phe Glu Arg Glu Asn Glu Gly Met Pro 
            900                 905                 910         


Ser Leu Ile Ala Glu Ser Asn Gln Cys Ile Gln Gln Leu Xaa Ser Glu 
        915                 920                 925             


Arg Phe Asp Ser Pro Ala Glu Glu Xaa Val Asn Ile Pro Leu Lys Glu 
    930                 935                 940                 


Asp Glu Asp Ala Met Pro Leu Ile Gly Pro Glu Xaa Leu Val Cys His 
945                 950                 955                 960 


Glu Val Asp Leu Asp Asp Leu Asp Glu Lys Asp Lys Xaa Ser Ile Glu 
                965                 970                 975     


Asp Val Ala Val Glu Ser Ser Glu Ser Asn Ser Leu Val Ser Ile Pro 
            980                 985                 990         


Pro Ala Leu Pro Pro Val Val Gln  His Asn Phe Ser Val  Ala Ser Pro 
        995                 1000                 1005             


Leu Xaa  Leu Ser Gln Asp Glu  Ser Arg Ser Val Lys  Ser Glu Ser 
    1010                 1015                 1020             


Asp Ile  Xaa Ile Glu Val Asp  Ser Ile Ala Glu Glu  Ser Gln Glu 
    1025                 1030                 1035             


Gly Leu  Cys Glu Arg Glu Ser  Ala Asn Gly Phe Glu  Xaa Asn Val 
    1040                 1045                 1050             


Ala Ser  Gly Xaa Cys Ser Ile  Ile Val Gln Glu Arg  Glu Ser Arg 
    1055                 1060                 1065             


Glu Lys  Gly Gln Lys Arg Pro  Ser Asp Gly Asn Ser  Gly Leu Met 
    1070                 1075                 1080             


Ala Lys  Lys Gln Lys Arg Xaa  Pro Lys Arg Xaa Ser  Ala Ala Ala 
    1085                 1090                 1095             


Lys Asn  Glu Lys Asn Gly Xaa  Asp Glu Leu Asp Asn  Met Asn Ser 
    1100                 1105                 1110             


Xaa Glu  Arg Ile Ser Phe Leu  Gln Glu Lys Leu Gln  Glu Ile Arg 
    1115                 1120                 1125             


Lys Tyr  Tyr Met Ser Leu Lys  Ser Glu Val Ala Xaa  Ile Asp Arg 
    1130                 1135                 1140             


Arg Arg  Lys Arg Leu Lys Lys  Lys Asp Arg Glu Val  Ser His Ala 
    1145                 1150                 1155             


Gly Ala  Ser Met Ser Ser Ala  Ser Ser Asp Xaa Gly  Met Ser Pro 
    1160                 1165                 1170             


Ser Ser  Ser Ser Pro Pro Gln  Asn Val Leu Ala Val  Glu Cys Arg 
    1175                 1180                 1185             


<210> 3138
<211> 1203
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1105)..(1105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1184)..(1184)
<223> Selenocysteine

<400> 3138
Met Lys Ala Ala Asp Glu Pro Ala Tyr Leu Xaa Val Gly Xaa Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Xaa Val 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Leu Leu Lys Gln Asp Asn Xaa Xaa 
        35                  40                  45              


Gln Leu Val Gln Asp Asp Gln Val Lys Gly Pro Leu Arg Val Gly Ala 
    50                  55                  60                  


Ile Val Glu Xaa Arg Xaa Ser Asp Gly Ser Phe Gln Glu Ala Ile Ile 
65                  70                  75                  80  


Ser Lys Leu Xaa Asp Ala Ser Trp Tyr Xaa Val Val Phe Asp Asp Gly 
                85                  90                  95      


Asp Glu Arg Xaa Leu Arg Arg Xaa Ser Leu Cys Leu Lys Gly Glu Arg 
            100                 105                 110         


His Phe Ala Glu Ser Glu Xaa Leu Asp Gln Leu Pro Leu Xaa Asn Pro 
        115                 120                 125             


Glu His Phe Gly Xaa Pro Val Ile Ala Lys Lys Xaa Asn Arg Gly Arg 
    130                 135                 140                 


Arg Ser Ser Leu Pro Val Xaa Glu Asp Glu Lys Glu Glu Glu Ser Ser 
145                 150                 155                 160 


Glu Glu Glu Asp Glu Asp Lys Arg Arg Leu Asn Asp Glu Leu Leu Gly 
                165                 170                 175     


Lys Val Val Ser Val Val Ser Ala Xaa Glu Arg Xaa Glu Trp Tyr Pro 
            180                 185                 190         


Ala Leu Val Ile Ser Pro Ser Cys Asn Asp Asp Ile Xaa Val Lys Lys 
        195                 200                 205             


Asp Gln Cys Leu Val Arg Ser Phe Ile Asp Ser Lys Phe Tyr Ser Ile 
    210                 215                 220                 


Ala Arg Lys Asp Ile Lys Glu Val Asp Ile Leu Asn Leu Pro Glu Ser 
225                 230                 235                 240 


Glu Leu Ser Xaa Lys Pro Gly Leu Gln Lys Ala Ser Ile Phe Leu Lys 
                245                 250                 255     


Xaa Arg Val Val Pro Asp Asn Trp Lys Met Asp Ile Ser Glu Ile Leu 
            260                 265                 270         


Glu Ser Ser Ser Ser Asp Asp Glu Asp Gly Pro Ala Glu Glu Asn Asp 
        275                 280                 285             


Glu Glu Lys Glu Lys Glu Ala Lys Lys Xaa Glu Glu Glu Val Pro Glu 
    290                 295                 300                 


Glu Glu Leu Asp Pro Glu Glu Arg Asp Asn Phe Leu Gln Gln Leu Tyr 
305                 310                 315                 320 


Lys Phe Met Glu Asp Arg Gly Xaa Pro Ile Asn Lys Pro Pro Val Leu 
                325                 330                 335     


Gly Tyr Lys Asp Leu Asn Leu Phe Lys Leu Phe Arg Leu Val Tyr His 
            340                 345                 350         


Gln Gly Gly Cys Asp Asn Ile Asp Ser Gly Ala Val Trp Lys Gln Ile 
        355                 360                 365             


Tyr Met Asp Leu Gly Ile Pro Ile Leu Asn Ser Ala Ala Ser Tyr Asn 
    370                 375                 380                 


Val Lys Xaa Ala Tyr Arg Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys 
385                 390                 395                 400 


Arg Ser Ala Asn Ile Gln Phe Arg Xaa Val His His His Glu Pro Lys 
                405                 410                 415     


Val Lys Glu Glu Lys Lys Asp Leu Glu Glu Ser Met Glu Glu Ala Leu 
            420                 425                 430         


Lys Leu Asp Gln Glu Met Pro Leu Xaa Glu Val Lys Ser Glu Pro Glu 
        435                 440                 445             


Glu Asn Ile Asp Ser Asn Ser Glu Ser Glu Arg Glu Glu Ile Glu Leu 
    450                 455                 460                 


Lys Ser Pro Arg Gly Arg Arg Arg Ile Ala Arg Asp Val Asn Ser Ile 
465                 470                 475                 480 


Lys Lys Glu Ile Glu Glu Glu Lys Xaa Glu Asp Lys Leu Lys Asp Asn 
                485                 490                 495     


Asp Xaa Glu Asn Lys Asp Val Asp Asp Asp Tyr Glu Xaa Ala Glu Lys 
            500                 505                 510         


Lys Glu Asn Glu Leu Leu Leu Gly Arg Lys Asn Xaa Pro Lys Gln Lys 
        515                 520                 525             


Glu Lys Lys Ile Lys Lys Gln Glu Asp Ser Asp Lys Asp Ser Asp Glu 
    530                 535                 540                 


Glu Glu Glu Lys Ser Gln Glu Arg Glu Glu Xaa Glu Ser Lys Cys Asp 
545                 550                 555                 560 


Ser Glu Gly Glu Glu Asp Glu Glu Asp Met Glu Pro Cys Leu Xaa Gly 
                565                 570                 575     


Xaa Lys Val Lys Val Lys Tyr Gly Arg Gly Lys Xaa Gln Lys Ile Tyr 
            580                 585                 590         


Glu Ala Ser Ile Lys Ser Xaa Glu Ile Asp Asp Gly Glu Val Leu Tyr 
        595                 600                 605             


Leu Val His Tyr Tyr Gly Trp Asn Val Arg Tyr Asp Glu Trp Val Lys 
    610                 615                 620                 


Ala Asp Arg Ile Ile Trp Pro Leu Asp Lys Gly Gly Pro Lys Lys Lys 
625                 630                 635                 640 


Gln Lys Lys Lys Ala Lys Asn Lys Glu Asp Ser Glu Lys Asp Glu Lys 
                645                 650                 655     


Arg Asp Glu Glu Arg Gln Lys Ser Lys Arg Gly Arg Pro Pro Leu Lys 
            660                 665                 670         


Ser Xaa Leu Ser Ser Asn Met Pro Tyr Gly Leu Ser Lys Xaa Ala Asn 
        675                 680                 685             


Ser Glu Gly Lys Ser Asp Ser Cys Ser Ser Asp Ser Glu Xaa Glu Asp 
    690                 695                 700                 


Ala Leu Glu Lys Asn Leu Ile Asn Glu Glu Leu Ser Leu Lys Asp Glu 
705                 710                 715                 720 


Leu Glu Lys Asn Glu Asn Leu Asn Asp Asp Lys Leu Asp Glu Glu Asn 
                725                 730                 735     


Pro Lys Ile Ser Ala His Ile Leu Lys Glu Asn Asp Arg Xaa Gln Met 
            740                 745                 750         


Gln Pro Leu Glu Xaa Leu Lys Leu Glu Val Gly Glu Asn Glu Gln Ile 
        755                 760                 765             


Val Gln Ile Phe Gly Asn Lys Met Glu Lys Xaa Glu Glu Val Lys Lys 
    770                 775                 780                 


Glu Ala Glu Lys Ser Pro Lys Gly Lys Gly Arg Arg Ser Lys Xaa Lys 
785                 790                 795                 800 


Asp Leu Ser Leu Glu Ile Ile Lys Ile Ser Ser Phe Gly Gln Asn Glu 
                805                 810                 815     


Ala Gly Ser Glu Pro His Ile Glu Ala His Ser Leu Glu Leu Ser Ser 
            820                 825                 830         


Leu Asp Asn Lys Asn Phe Ser Ser Ala Xaa Glu Asp Glu Ile Asp Gln 
        835                 840                 845             


Cys Val Lys Glu Lys Lys Leu Lys Arg Lys Ile Leu Gly Gln Ser Ser 
    850                 855                 860                 


Pro Glu Lys Lys Ile Arg Ile Glu Asn Gly Met Glu Met Xaa Asn Xaa 
865                 870                 875                 880 


Val Ser Gln Glu Arg Xaa Ser Asp Cys Ile Gly Ser Glu Gly Met Lys 
                885                 890                 895     


Asn Leu Asn Phe Glu Gln His Phe Glu Arg Glu Asn Glu Gly Met Pro 
            900                 905                 910         


Ser Leu Ile Ala Glu Ser Asn Gln Cys Ile Gln Gln Leu Xaa Ser Glu 
        915                 920                 925             


Arg Phe Asp Ser Pro Ala Glu Glu Xaa Val Asn Ile Pro Leu Lys Glu 
    930                 935                 940                 


Asp Glu Asp Ala Met Pro Leu Ile Gly Pro Glu Xaa Leu Val Cys His 
945                 950                 955                 960 


Glu Val Asp Leu Asp Asp Leu Asp Glu Lys Asp Lys Xaa Ser Ile Glu 
                965                 970                 975     


Asp Val Ala Val Glu Ser Ser Glu Ser Asn Ser Leu Val Ser Ile Pro 
            980                 985                 990         


Pro Ala Leu Pro Pro Val Val Gln  His Asn Phe Ser Val  Ala Ser Pro 
        995                 1000                 1005             


Leu Xaa  Leu Ser Gln Asp Glu  Ser Arg Ser Val Lys  Ser Glu Ser 
    1010                 1015                 1020             


Asp Ile  Xaa Ile Glu Val Asp  Ser Ile Ala Glu Glu  Ser Gln Glu 
    1025                 1030                 1035             


Gly Leu  Cys Glu Arg Glu Ser  Ala Asn Gly Phe Glu  Xaa Asn Val 
    1040                 1045                 1050             


Ala Ser  Gly Xaa Cys Ser Ile  Ile Val Gln Glu Arg  Glu Ser Arg 
    1055                 1060                 1065             


Glu Lys  Gly Gln Lys Arg Pro  Ser Asp Gly Asn Ser  Gly Leu Met 
    1070                 1075                 1080             


Ala Lys  Lys Gln Lys Arg Xaa  Pro Lys Arg Xaa Ser  Ala Ala Ala 
    1085                 1090                 1095             


Lys Asn  Glu Lys Asn Gly Xaa  Gly Gln Ser Ser Asp  Ser Glu Asp 
    1100                 1105                 1110             


Leu Pro  Val Leu Asp Asn Ser  Asn Glu Leu Asp Asn  Met Asn Ser 
    1115                 1120                 1125             


Xaa Glu  Arg Ile Ser Phe Leu  Gln Glu Lys Leu Gln  Glu Ile Arg 
    1130                 1135                 1140             


Lys Tyr  Tyr Met Ser Leu Lys  Ser Glu Val Ala Xaa  Ile Asp Arg 
    1145                 1150                 1155             


Arg Arg  Lys Arg Leu Lys Lys  Lys Asp Arg Glu Val  Ser His Ala 
    1160                 1165                 1170             


Gly Ala  Ser Met Ser Ser Ala  Ser Ser Asp Xaa Gly  Met Ser Pro 
    1175                 1180                 1185             


Ser Ser  Ser Ser Pro Pro Gln  Asn Val Leu Ala Val  Glu Cys Arg 
    1190                 1195                 1200             


<210> 3139
<211> 1257
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1105)..(1105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1238)..(1238)
<223> Selenocysteine

<400> 3139
Met Lys Ala Ala Asp Glu Pro Ala Tyr Leu Xaa Val Gly Xaa Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Xaa Val 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Leu Leu Lys Gln Asp Asn Xaa Xaa 
        35                  40                  45              


Gln Leu Val Gln Asp Asp Gln Val Lys Gly Pro Leu Arg Val Gly Ala 
    50                  55                  60                  


Ile Val Glu Xaa Arg Xaa Ser Asp Gly Ser Phe Gln Glu Ala Ile Ile 
65                  70                  75                  80  


Ser Lys Leu Xaa Asp Ala Ser Trp Tyr Xaa Val Val Phe Asp Asp Gly 
                85                  90                  95      


Asp Glu Arg Xaa Leu Arg Arg Xaa Ser Leu Cys Leu Lys Gly Glu Arg 
            100                 105                 110         


His Phe Ala Glu Ser Glu Xaa Leu Asp Gln Leu Pro Leu Xaa Asn Pro 
        115                 120                 125             


Glu His Phe Gly Xaa Pro Val Ile Ala Lys Lys Xaa Asn Arg Gly Arg 
    130                 135                 140                 


Arg Ser Ser Leu Pro Val Xaa Glu Asp Glu Lys Glu Glu Glu Ser Ser 
145                 150                 155                 160 


Glu Glu Glu Asp Glu Asp Lys Arg Arg Leu Asn Asp Glu Leu Leu Gly 
                165                 170                 175     


Lys Val Val Ser Val Val Ser Ala Xaa Glu Arg Xaa Glu Trp Tyr Pro 
            180                 185                 190         


Ala Leu Val Ile Ser Pro Ser Cys Asn Asp Asp Ile Xaa Val Lys Lys 
        195                 200                 205             


Asp Gln Cys Leu Val Arg Ser Phe Ile Asp Ser Lys Phe Tyr Ser Ile 
    210                 215                 220                 


Ala Arg Lys Asp Ile Lys Glu Val Asp Ile Leu Asn Leu Pro Glu Ser 
225                 230                 235                 240 


Glu Leu Ser Xaa Lys Pro Gly Leu Gln Lys Ala Ser Ile Phe Leu Lys 
                245                 250                 255     


Xaa Arg Val Val Pro Asp Asn Trp Lys Met Asp Ile Ser Glu Ile Leu 
            260                 265                 270         


Glu Ser Ser Ser Ser Asp Asp Glu Asp Gly Pro Ala Glu Glu Asn Asp 
        275                 280                 285             


Glu Glu Lys Glu Lys Glu Ala Lys Lys Xaa Glu Glu Glu Val Pro Glu 
    290                 295                 300                 


Glu Glu Leu Asp Pro Glu Glu Arg Asp Asn Phe Leu Gln Gln Leu Tyr 
305                 310                 315                 320 


Lys Phe Met Glu Asp Arg Gly Xaa Pro Ile Asn Lys Pro Pro Val Leu 
                325                 330                 335     


Gly Tyr Lys Asp Leu Asn Leu Phe Lys Leu Phe Arg Leu Val Tyr His 
            340                 345                 350         


Gln Gly Gly Cys Asp Asn Ile Asp Ser Gly Ala Val Trp Lys Gln Ile 
        355                 360                 365             


Tyr Met Asp Leu Gly Ile Pro Ile Leu Asn Ser Ala Ala Ser Tyr Asn 
    370                 375                 380                 


Val Lys Xaa Ala Tyr Arg Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys 
385                 390                 395                 400 


Arg Ser Ala Asn Ile Gln Phe Arg Xaa Val His His His Glu Pro Lys 
                405                 410                 415     


Val Lys Glu Glu Lys Lys Asp Leu Glu Glu Ser Met Glu Glu Ala Leu 
            420                 425                 430         


Lys Leu Asp Gln Glu Met Pro Leu Xaa Glu Val Lys Ser Glu Pro Glu 
        435                 440                 445             


Glu Asn Ile Asp Ser Asn Ser Glu Ser Glu Arg Glu Glu Ile Glu Leu 
    450                 455                 460                 


Lys Ser Pro Arg Gly Arg Arg Arg Ile Ala Arg Asp Val Asn Ser Ile 
465                 470                 475                 480 


Lys Lys Glu Ile Glu Glu Glu Lys Xaa Glu Asp Lys Leu Lys Asp Asn 
                485                 490                 495     


Asp Xaa Glu Asn Lys Asp Val Asp Asp Asp Tyr Glu Xaa Ala Glu Lys 
            500                 505                 510         


Lys Glu Asn Glu Leu Leu Leu Gly Arg Lys Asn Xaa Pro Lys Gln Lys 
        515                 520                 525             


Glu Lys Lys Ile Lys Lys Gln Glu Asp Ser Asp Lys Asp Ser Asp Glu 
    530                 535                 540                 


Glu Glu Glu Lys Ser Gln Glu Arg Glu Glu Xaa Glu Ser Lys Cys Asp 
545                 550                 555                 560 


Ser Glu Gly Glu Glu Asp Glu Glu Asp Met Glu Pro Cys Leu Xaa Gly 
                565                 570                 575     


Xaa Lys Val Lys Val Lys Tyr Gly Arg Gly Lys Xaa Gln Lys Ile Tyr 
            580                 585                 590         


Glu Ala Ser Ile Lys Ser Xaa Glu Ile Asp Asp Gly Glu Val Leu Tyr 
        595                 600                 605             


Leu Val His Tyr Tyr Gly Trp Asn Val Arg Tyr Asp Glu Trp Val Lys 
    610                 615                 620                 


Ala Asp Arg Ile Ile Trp Pro Leu Asp Lys Gly Gly Pro Lys Lys Lys 
625                 630                 635                 640 


Gln Lys Lys Lys Ala Lys Asn Lys Glu Asp Ser Glu Lys Asp Glu Lys 
                645                 650                 655     


Arg Asp Glu Glu Arg Gln Lys Ser Lys Arg Gly Arg Pro Pro Leu Lys 
            660                 665                 670         


Ser Xaa Leu Ser Ser Asn Met Pro Tyr Gly Leu Ser Lys Xaa Ala Asn 
        675                 680                 685             


Ser Glu Gly Lys Ser Asp Ser Cys Ser Ser Asp Ser Glu Xaa Glu Asp 
    690                 695                 700                 


Ala Leu Glu Lys Asn Leu Ile Asn Glu Glu Leu Ser Leu Lys Asp Glu 
705                 710                 715                 720 


Leu Glu Lys Asn Glu Asn Leu Asn Asp Asp Lys Leu Asp Glu Glu Asn 
                725                 730                 735     


Pro Lys Ile Ser Ala His Ile Leu Lys Glu Asn Asp Arg Xaa Gln Met 
            740                 745                 750         


Gln Pro Leu Glu Xaa Leu Lys Leu Glu Val Gly Glu Asn Glu Gln Ile 
        755                 760                 765             


Val Gln Ile Phe Gly Asn Lys Met Glu Lys Xaa Glu Glu Val Lys Lys 
    770                 775                 780                 


Glu Ala Glu Lys Ser Pro Lys Gly Lys Gly Arg Arg Ser Lys Xaa Lys 
785                 790                 795                 800 


Asp Leu Ser Leu Glu Ile Ile Lys Ile Ser Ser Phe Gly Gln Asn Glu 
                805                 810                 815     


Ala Gly Ser Glu Pro His Ile Glu Ala His Ser Leu Glu Leu Ser Ser 
            820                 825                 830         


Leu Asp Asn Lys Asn Phe Ser Ser Ala Xaa Glu Asp Glu Ile Asp Gln 
        835                 840                 845             


Cys Val Lys Glu Lys Lys Leu Lys Arg Lys Ile Leu Gly Gln Ser Ser 
    850                 855                 860                 


Pro Glu Lys Lys Ile Arg Ile Glu Asn Gly Met Glu Met Xaa Asn Xaa 
865                 870                 875                 880 


Val Ser Gln Glu Arg Xaa Ser Asp Cys Ile Gly Ser Glu Gly Met Lys 
                885                 890                 895     


Asn Leu Asn Phe Glu Gln His Phe Glu Arg Glu Asn Glu Gly Met Pro 
            900                 905                 910         


Ser Leu Ile Ala Glu Ser Asn Gln Cys Ile Gln Gln Leu Xaa Ser Glu 
        915                 920                 925             


Arg Phe Asp Ser Pro Ala Glu Glu Xaa Val Asn Ile Pro Leu Lys Glu 
    930                 935                 940                 


Asp Glu Asp Ala Met Pro Leu Ile Gly Pro Glu Xaa Leu Val Cys His 
945                 950                 955                 960 


Glu Val Asp Leu Asp Asp Leu Asp Glu Lys Asp Lys Xaa Ser Ile Glu 
                965                 970                 975     


Asp Val Ala Val Glu Ser Ser Glu Ser Asn Ser Leu Val Ser Ile Pro 
            980                 985                 990         


Pro Ala Leu Pro Pro Val Val Gln  His Asn Phe Ser Val  Ala Ser Pro 
        995                 1000                 1005             


Leu Xaa  Leu Ser Gln Asp Glu  Ser Arg Ser Val Lys  Ser Glu Ser 
    1010                 1015                 1020             


Asp Ile  Xaa Ile Glu Val Asp  Ser Ile Ala Glu Glu  Ser Gln Glu 
    1025                 1030                 1035             


Gly Leu  Cys Glu Arg Glu Ser  Ala Asn Gly Phe Glu  Xaa Asn Val 
    1040                 1045                 1050             


Ala Ser  Gly Xaa Cys Ser Ile  Ile Val Gln Glu Arg  Glu Ser Arg 
    1055                 1060                 1065             


Glu Lys  Gly Gln Lys Arg Pro  Ser Asp Gly Asn Ser  Gly Leu Met 
    1070                 1075                 1080             


Ala Lys  Lys Gln Lys Arg Xaa  Pro Lys Arg Xaa Ser  Ala Ala Ala 
    1085                 1090                 1095             


Lys Asn  Glu Lys Asn Gly Xaa  Gly Gln Ser Ser Asp  Ser Glu Asp 
    1100                 1105                 1110             


Leu Pro  Val Leu Asp Asn Ser  Ser Lys Cys Xaa Pro  Val Lys His 
    1115                 1120                 1125             


Leu Asn  Val Ser Lys Pro Gln  Lys Leu Ala Arg Ser  Pro Ala Arg 
    1130                 1135                 1140             


Ile Ser  Pro His Ile Lys Asp  Gly Glu Lys Asp Lys  His Arg Glu 
    1145                 1150                 1155             


Lys His  Pro Asn Ser Ser Pro  Arg Xaa Tyr Lys Trp  Ser Phe Gln 
    1160                 1165                 1170             


Leu Asn  Glu Leu Asp Asn Met  Asn Ser Xaa Glu Arg  Ile Ser Phe 
    1175                 1180                 1185             


Leu Gln  Glu Lys Leu Gln Glu  Ile Arg Lys Tyr Tyr  Met Ser Leu 
    1190                 1195                 1200             


Lys Ser  Glu Val Ala Xaa Ile  Asp Arg Arg Arg Lys  Arg Leu Lys 
    1205                 1210                 1215             


Lys Lys  Asp Arg Glu Val Ser  His Ala Gly Ala Ser  Met Ser Ser 
    1220                 1225                 1230             


Ala Ser  Ser Asp Xaa Gly Met  Ser Pro Ser Ser Ser  Ser Pro Pro 
    1235                 1240                 1245             


Gln Asn  Val Leu Ala Val Glu  Cys Arg 
    1250                 1255         


<210> 3140
<211> 265
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<400> 3140
Met Lys Val Leu Leu Lys Gln Asp Asn Xaa Xaa Gln Leu Val Gln Asp 
1               5                   10                  15      


Asp Gln Val Lys Gly Pro Leu Arg Val Gly Ala Ile Val Glu Xaa Arg 
            20                  25                  30          


Xaa Ser Asp Gly Ser Phe Gln Glu Ala Ile Ile Ser Lys Leu Xaa Asp 
        35                  40                  45              


Ala Ser Trp Tyr Xaa Val Val Phe Asp Asp Gly Asp Glu Arg Xaa Leu 
    50                  55                  60                  


Arg Arg Xaa Ser Leu Cys Leu Lys Gly Glu Arg His Phe Ala Glu Ser 
65                  70                  75                  80  


Glu Xaa Leu Asp Gln Leu Pro Leu Xaa Asn Pro Glu His Phe Gly Xaa 
                85                  90                  95      


Pro Val Ile Ala Lys Lys Xaa Asn Arg Gly Arg Arg Ser Ser Leu Pro 
            100                 105                 110         


Val Xaa Glu Asp Glu Lys Glu Glu Glu Ser Ser Glu Glu Glu Asp Glu 
        115                 120                 125             


Asp Lys Arg Arg Leu Asn Asp Glu Leu Leu Gly Lys Val Val Ser Val 
    130                 135                 140                 


Val Ser Ala Xaa Glu Arg Xaa Glu Trp Tyr Pro Ala Leu Val Ile Ser 
145                 150                 155                 160 


Pro Ser Cys Asn Asp Asp Ile Xaa Val Lys Lys Asp Gln Cys Leu Val 
                165                 170                 175     


Arg Ser Phe Ile Asp Ser Lys Phe Tyr Ser Ile Ala Arg Lys Asp Ile 
            180                 185                 190         


Lys Glu Val Asp Ile Leu Asn Leu Pro Glu Ser Glu Leu Ser Xaa Lys 
        195                 200                 205             


Pro Gly Leu Gln Lys Ala Ser Ile Phe Leu Lys Xaa Arg Val Val Pro 
    210                 215                 220                 


Asp Asn Trp Lys Met Asp Ile Ser Glu Ile Leu Glu Ser Ser Ser Ser 
225                 230                 235                 240 


Asp Asp Glu Asp Gly Pro Ala Glu Glu Asn Asp Glu Glu Lys Glu Lys 
                245                 250                 255     


Glu Ala Lys Lys Xaa Glu Glu Glu Val 
            260                 265 


<210> 3141
<211> 483
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<400> 3141
Met Lys Ala Leu Asp Glu Pro Pro Tyr Leu Xaa Val Gly Xaa Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Xaa Ala 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Xaa Phe Arg His Asp Ser Ser Xaa 
        35                  40                  45              


Val Glu Val Gln Asp Asp His Ile Lys Gly Pro Leu Lys Val Gly Ala 
    50                  55                  60                  


Ile Val Glu Val Lys Asn Leu Asp Gly Ala Tyr Gln Glu Ala Val Ile 
65                  70                  75                  80  


Asn Lys Leu Xaa Asp Ala Ser Trp Tyr Xaa Val Val Phe Asp Asp Gly 
                85                  90                  95      


Asp Glu Lys Xaa Leu Arg Arg Ser Ser Leu Cys Leu Lys Gly Glu Arg 
            100                 105                 110         


His Phe Ala Glu Ser Glu Xaa Leu Asp Gln Leu Pro Leu Xaa Asn Pro 
        115                 120                 125             


Glu His Phe Gly Xaa Pro Val Ile Gly Lys Lys Xaa Asn Arg Gly Arg 
    130                 135                 140                 


Arg Ser Asn His Ile Pro Glu Glu Glu Ser Ser Ser Ser Ser Ser Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Asp Arg Lys Gln Ile Asp Glu Leu Leu Gly Lys Val 
                165                 170                 175     


Val Cys Val Asp Tyr Ile Ser Leu Asp Lys Lys Lys Ala Leu Trp Phe 
            180                 185                 190         


Pro Ala Leu Val Val Cys Pro Asp Cys Ser Asp Glu Ile Ala Val Lys 
        195                 200                 205             


Lys Asp Asn Ile Leu Val Arg Ser Phe Lys Asp Gly Lys Phe Xaa Ser 
    210                 215                 220                 


Val Pro Arg Lys Asp Val His Glu Ile Xaa Ser Asp Xaa Ala Pro Lys 
225                 230                 235                 240 


Pro Asp Ala Val Leu Lys Gln Ala Phe Glu Gln Ala Leu Glu Phe His 
                245                 250                 255     


Lys Ser Arg Xaa Ile Pro Ala Asn Trp Lys Xaa Glu Leu Lys Glu Asp 
            260                 265                 270         


Ser Ser Ser Ser Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu 
        275                 280                 285             


Lys Glu Lys Glu Asp Asn Ser Ser Glu Glu Glu Glu Glu Ile Glu Pro 
    290                 295                 300                 


Phe Pro Glu Glu Arg Glu Asn Phe Leu Gln Gln Leu Tyr Lys Phe Met 
305                 310                 315                 320 


Glu Asp Arg Gly Xaa Pro Ile Asn Lys Arg Pro Val Leu Gly Tyr Arg 
                325                 330                 335     


Asn Leu Asn Leu Phe Lys Leu Phe Arg Leu Val His Lys Leu Gly Gly 
            340                 345                 350         


Phe Asp Asn Ile Glu Ser Gly Ala Val Trp Lys Gln Val Tyr Gln Asp 
        355                 360                 365             


Leu Gly Ile Pro Val Leu Asn Ser Ala Ala Gly Tyr Asn Val Lys Cys 
    370                 375                 380                 


Ala Tyr Lys Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys Arg Ser Ala 
385                 390                 395                 400 


Asn Ile Glu Phe Gln Met Ala Leu Pro Glu Lys Val Val Asn Lys Gln 
                405                 410                 415     


Cys Lys Glu Cys Glu Asn Val Lys Glu Ile Lys Val Lys Glu Glu Asn 
            420                 425                 430         


Glu Xaa Glu Ile Lys Glu Ile Lys Met Glu Glu Glu Arg Asn Ile Ile 
        435                 440                 445             


Pro Arg Glu Glu Lys Pro Ile Glu Asp Glu Ile Glu Arg Lys Glu Asn 
    450                 455                 460                 


Ile Lys Pro Ser Leu Gly Ser Lys Lys Asn Leu Leu Glu Ser Ile Pro 
465                 470                 475                 480 


Xaa His Ser 
            


<210> 3142
<211> 1153
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<400> 3142
Met Lys Ala Leu Asp Glu Pro Pro Tyr Leu Xaa Val Gly Xaa Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Xaa Ala 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Xaa Phe Arg His Asp Ser Ser Xaa 
        35                  40                  45              


Val Glu Val Gln Asp Asp His Ile Lys Gly Pro Leu Lys Val Gly Ala 
    50                  55                  60                  


Ile Val Glu Val Lys Asn Leu Asp Gly Ala Tyr Gln Glu Ala Val Ile 
65                  70                  75                  80  


Asn Lys Leu Xaa Asp Ala Ser Trp Tyr Xaa Val Val Phe Asp Asp Gly 
                85                  90                  95      


Asp Glu Lys Xaa Leu Arg Arg Ser Ser Leu Cys Leu Lys Gly Glu Arg 
            100                 105                 110         


His Phe Ala Glu Ser Glu Xaa Leu Asp Gln Leu Pro Leu Xaa Asn Pro 
        115                 120                 125             


Glu His Phe Gly Xaa Pro Val Ile Gly Lys Lys Xaa Asn Arg Gly Arg 
    130                 135                 140                 


Arg Ser Asn His Ile Pro Glu Glu Glu Ser Ser Ser Ser Ser Ser Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Asp Arg Lys Gln Ile Asp Glu Leu Leu Gly Lys Val 
                165                 170                 175     


Val Cys Val Asp Tyr Ile Ser Leu Asp Lys Lys Lys Ala Leu Trp Phe 
            180                 185                 190         


Pro Ala Leu Val Val Cys Pro Asp Cys Ser Asp Glu Ile Ala Val Lys 
        195                 200                 205             


Lys Asp Asn Ile Leu Val Arg Ser Phe Lys Asp Gly Lys Phe Xaa Ser 
    210                 215                 220                 


Val Pro Arg Lys Asp Val His Glu Ile Xaa Ser Asp Xaa Ala Pro Lys 
225                 230                 235                 240 


Pro Asp Ala Val Leu Lys Gln Ala Phe Glu Gln Ala Leu Glu Phe His 
                245                 250                 255     


Lys Ser Arg Xaa Ile Pro Ala Asn Trp Lys Xaa Glu Leu Lys Glu Asp 
            260                 265                 270         


Ser Ser Ser Ser Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu 
        275                 280                 285             


Lys Glu Lys Glu Asp Asn Ser Ser Glu Glu Glu Glu Glu Ile Glu Pro 
    290                 295                 300                 


Phe Pro Glu Glu Arg Glu Asn Phe Leu Gln Gln Leu Tyr Lys Phe Met 
305                 310                 315                 320 


Glu Asp Arg Gly Xaa Pro Ile Asn Lys Arg Pro Val Leu Gly Tyr Arg 
                325                 330                 335     


Asn Leu Asn Leu Phe Lys Leu Phe Arg Leu Val His Lys Leu Gly Gly 
            340                 345                 350         


Phe Asp Asn Ile Glu Ser Gly Ala Val Trp Lys Gln Val Tyr Gln Asp 
        355                 360                 365             


Leu Gly Ile Pro Val Leu Asn Ser Ala Ala Gly Tyr Asn Val Lys Cys 
    370                 375                 380                 


Ala Tyr Lys Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys Arg Ser Ala 
385                 390                 395                 400 


Asn Ile Glu Phe Gln Met Ala Leu Pro Glu Lys Val Val Asn Lys Gln 
                405                 410                 415     


Cys Lys Glu Cys Glu Asn Val Lys Glu Ile Lys Val Lys Glu Glu Asn 
            420                 425                 430         


Glu Xaa Glu Ile Lys Glu Ile Lys Met Glu Glu Glu Arg Asn Ile Ile 
        435                 440                 445             


Pro Arg Glu Glu Lys Pro Ile Glu Asp Glu Ile Glu Arg Lys Glu Asn 
    450                 455                 460                 


Ile Lys Pro Ser Leu Gly Ser Lys Lys Asn Leu Leu Glu Ser Ile Pro 
465                 470                 475                 480 


Xaa His Ser Asp Gln Glu Lys Glu Val Asn Ile Lys Lys Pro Glu Asp 
                485                 490                 495     


Asn Glu Asn Leu Asp Asp Lys Asp Asp Asp Xaa Xaa Arg Val Asp Glu 
            500                 505                 510         


Ser Leu Asn Ile Lys Val Glu Ala Glu Glu Glu Lys Ala Lys Ser Gly 
        515                 520                 525             


Asp Glu Xaa Asn Lys Glu Glu Asp Glu Asp Asp Glu Glu Ala Glu Glu 
    530                 535                 540                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Asp Asp Asp Asn 
545                 550                 555                 560 


Asn Glu Glu Glu Glu Phe Glu Cys Tyr Pro Pro Gly Met Lys Val Gln 
                565                 570                 575     


Val Arg Tyr Gly Arg Gly Lys Asn Gln Lys Met Tyr Glu Ala Ser Ile 
            580                 585                 590         


Lys Asp Ser Asp Val Glu Gly Gly Glu Val Leu Tyr Leu Val His Tyr 
        595                 600                 605             


Cys Gly Trp Asn Val Arg Tyr Asp Glu Trp Ile Lys Ala Asp Lys Ile 
    610                 615                 620                 


Val Arg Pro Ala Asp Lys Asn Val Pro Lys Ile Lys His Arg Lys Lys 
625                 630                 635                 640 


Ile Lys Asn Lys Leu Asp Lys Glu Lys Asp Lys Asp Glu Lys Tyr Ser 
                645                 650                 655     


Pro Lys Asn Cys Lys Leu Arg Arg Leu Ser Lys Pro Pro Phe Gln Xaa 
            660                 665                 670         


Asn Pro Ser Pro Glu Met Val Ser Lys Leu Asp Leu Xaa Asp Ala Lys 
        675                 680                 685             


Asn Ser Asp Xaa Ala His Ile Lys Ser Ile Glu Ile Xaa Ser Ile Leu 
    690                 695                 700                 


Asn Gly Leu Gln Ala Ser Glu Ser Ser Ala Glu Asp Ser Glu Gln Glu 
705                 710                 715                 720 


Asp Glu Arg Gly Ala Gln Asp Met Asp Asn Asn Gly Lys Glu Glu Ser 
                725                 730                 735     


Lys Ile Asp His Leu Xaa Asn Asn Arg Asn Asp Leu Ile Ser Lys Glu 
            740                 745                 750         


Glu Gln Asn Ser Ser Ser Leu Leu Glu Glu Asn Lys Val His Ala Asp 
        755                 760                 765             


Leu Val Ile Ser Lys Pro Val Ser Lys Ser Pro Glu Arg Leu Arg Lys 
    770                 775                 780                 


Asp Ile Glu Val Leu Ser Glu Asp Xaa Asp Tyr Glu Glu Asp Glu Val 
785                 790                 795                 800 


Xaa Lys Lys Arg Lys Asp Val Lys Lys Asp Xaa Xaa Asp Lys Ser Ser 
                805                 810                 815     


Lys Pro Gln Ile Lys Arg Gly Lys Arg Arg Tyr Cys Asn Xaa Glu Glu 
            820                 825                 830         


Cys Leu Lys Xaa Gly Ser Pro Gly Lys Lys Glu Glu Lys Ala Lys Asn 
        835                 840                 845             


Lys Glu Ser Leu Cys Met Glu Asn Ser Ser Asn Ser Ser Ser Asp Glu 
    850                 855                 860                 


Asp Glu Glu Glu Xaa Lys Ala Lys Met Xaa Pro Xaa Lys Lys Tyr Asn 
865                 870                 875                 880 


Gly Leu Glu Glu Lys Arg Lys Ser Leu Arg Xaa Xaa Gly Phe Tyr Ser 
                885                 890                 895     


Gly Phe Ser Glu Val Ala Glu Lys Arg Ile Lys Leu Leu Asn Asn Ser 
            900                 905                 910         


Asp Glu Arg Leu Gln Asn Ser Arg Ala Lys Asp Arg Lys Asp Val Trp 
        915                 920                 925             


Ser Ser Ile Gln Gly Gln Trp Pro Lys Lys Xaa Leu Lys Glu Leu Phe 
    930                 935                 940                 


Ser Asp Ser Asp Xaa Glu Ala Ala Ala Ser Pro Pro His Pro Ala Pro 
945                 950                 955                 960 


Glu Glu Gly Val Ala Glu Glu Ser Leu Gln Xaa Val Ala Glu Glu Glu 
                965                 970                 975     


Ser Cys Ser Pro Ser Val Glu Leu Glu Lys Pro Pro Pro Val Asn Val 
            980                 985                 990         


Asp Ser Lys Pro Ile Glu Glu Lys  Xaa Val Glu Val Asn  Asp Arg Lys 
        995                 1000                 1005             


Ala Glu  Phe Pro Ser Ser Gly  Ser Asn Ser Val Leu  Asn Xaa Pro 
    1010                 1015                 1020             


Pro Xaa  Xaa Pro Glu Ser Pro  Ser Ser Val Xaa Val  Xaa Glu Gly 
    1025                 1030                 1035             


Ser Arg  Gln Gln Ser Ser Val  Xaa Val Ser Glu Pro  Leu Ala Pro 
    1040                 1045                 1050             


Asn Gln  Glu Glu Val Arg Ser  Ile Lys Ser Glu Xaa  Asp Ser Xaa 
    1055                 1060                 1065             


Ile Glu  Val Asp Ser Val Ala  Gly Glu Leu Gln Asp  Leu Gln Ser 
    1070                 1075                 1080             


Glu Gly  Asn Ser Ser Pro Ala  Gly Phe Asp Ala Ser  Val Ser Ser 
    1085                 1090                 1095             


Ser Ser  Ser Asn Gln Pro Glu  Pro Glu His Pro Glu  Lys Ala Cys 
    1100                 1105                 1110             


Xaa Gly  Gln Lys Arg Val Lys  Asp Ala Gln Gly Gly  Gly Ser Ser 
    1115                 1120                 1125             


Ser Lys  Lys Gln Lys Arg Ser  His Lys Ala Xaa Val  Val Asn Asn 
    1130                 1135                 1140             


Lys Lys  Lys Gly Lys Gly Ser  Ala Pro His 
    1145                 1150             


<210> 3143
<211> 1226
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<400> 3143
Met Lys Ala Leu Asp Glu Pro Pro Tyr Leu Xaa Val Gly Xaa Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Xaa Ala 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Xaa Phe Arg His Asp Ser Ser Xaa 
        35                  40                  45              


Val Glu Val Gln Asp Asp His Ile Lys Gly Pro Leu Lys Val Gly Ala 
    50                  55                  60                  


Ile Val Glu Val Lys Asn Leu Asp Gly Ala Tyr Gln Glu Ala Val Ile 
65                  70                  75                  80  


Asn Lys Leu Xaa Asp Ala Ser Trp Tyr Xaa Val Val Phe Asp Asp Gly 
                85                  90                  95      


Asp Glu Lys Xaa Leu Arg Arg Ser Ser Leu Cys Leu Lys Gly Glu Arg 
            100                 105                 110         


His Phe Ala Glu Ser Glu Xaa Leu Asp Gln Leu Pro Leu Xaa Asn Pro 
        115                 120                 125             


Glu His Phe Gly Xaa Pro Val Ile Gly Lys Lys Xaa Asn Arg Gly Arg 
    130                 135                 140                 


Arg Ser Asn His Ile Pro Glu Glu Glu Ser Ser Ser Ser Ser Ser Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Asp Arg Lys Gln Ile Asp Glu Leu Leu Gly Lys Val 
                165                 170                 175     


Val Cys Val Asp Tyr Ile Ser Leu Asp Lys Lys Lys Ala Leu Trp Phe 
            180                 185                 190         


Pro Ala Leu Val Val Cys Pro Asp Cys Ser Asp Glu Ile Ala Val Lys 
        195                 200                 205             


Lys Asp Asn Ile Leu Val Arg Ser Phe Lys Asp Gly Lys Phe Xaa Ser 
    210                 215                 220                 


Val Pro Arg Lys Asp Val His Glu Ile Xaa Ser Asp Xaa Ala Pro Lys 
225                 230                 235                 240 


Pro Asp Ala Val Leu Lys Gln Ala Phe Glu Gln Ala Leu Glu Phe His 
                245                 250                 255     


Lys Ser Arg Xaa Ile Pro Ala Asn Trp Lys Xaa Glu Leu Lys Glu Asp 
            260                 265                 270         


Ser Ser Ser Ser Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu 
        275                 280                 285             


Lys Glu Lys Glu Asp Asn Ser Ser Glu Glu Glu Glu Glu Ile Glu Pro 
    290                 295                 300                 


Phe Pro Glu Glu Arg Glu Asn Phe Leu Gln Gln Leu Tyr Lys Phe Met 
305                 310                 315                 320 


Glu Asp Arg Gly Xaa Pro Ile Asn Lys Arg Pro Val Leu Gly Tyr Arg 
                325                 330                 335     


Asn Leu Asn Leu Phe Lys Leu Phe Arg Leu Val His Lys Leu Gly Gly 
            340                 345                 350         


Phe Asp Asn Ile Glu Ser Gly Ala Val Trp Lys Gln Val Tyr Gln Asp 
        355                 360                 365             


Leu Gly Ile Pro Val Leu Asn Ser Ala Ala Gly Tyr Asn Val Lys Cys 
    370                 375                 380                 


Ala Tyr Lys Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys Arg Ser Ala 
385                 390                 395                 400 


Asn Ile Glu Phe Gln Met Ala Leu Pro Glu Lys Val Val Asn Lys Gln 
                405                 410                 415     


Cys Lys Glu Cys Glu Asn Val Lys Glu Ile Lys Val Lys Glu Glu Asn 
            420                 425                 430         


Glu Xaa Glu Ile Lys Glu Ile Lys Met Glu Glu Glu Arg Asn Ile Ile 
        435                 440                 445             


Pro Arg Glu Glu Lys Pro Ile Glu Asp Glu Ile Glu Arg Lys Glu Asn 
    450                 455                 460                 


Ile Lys Pro Ser Leu Gly Ser Lys Lys Asn Leu Leu Glu Ser Ile Pro 
465                 470                 475                 480 


Xaa His Ser Asp Gln Glu Lys Glu Val Asn Ile Lys Lys Pro Glu Asp 
                485                 490                 495     


Asn Glu Asn Leu Asp Asp Lys Asp Asp Asp Xaa Xaa Arg Val Asp Glu 
            500                 505                 510         


Ser Leu Asn Ile Lys Val Glu Ala Glu Glu Glu Lys Ala Lys Ser Gly 
        515                 520                 525             


Tyr Asp Glu Trp Ile Lys Ala Asp Lys Ile Val Arg Pro Ala Asp Lys 
    530                 535                 540                 


Asn Val Pro Lys Ile Lys His Arg Lys Lys Ile Lys Asn Lys Leu Asp 
545                 550                 555                 560 


Lys Glu Lys Asp Lys Asp Glu Lys Tyr Ser Pro Lys Asn Cys Lys Leu 
                565                 570                 575     


Arg Arg Leu Ser Lys Pro Pro Phe Gln Xaa Asn Pro Ser Pro Glu Met 
            580                 585                 590         


Val Ser Lys Leu Asp Leu Xaa Asp Ala Lys Asn Ser Asp Xaa Ala His 
        595                 600                 605             


Ile Lys Ser Ile Glu Ile Xaa Ser Ile Leu Asn Gly Leu Gln Ala Ser 
    610                 615                 620                 


Glu Ser Ser Ala Glu Asp Ser Glu Gln Glu Asp Glu Arg Gly Ala Gln 
625                 630                 635                 640 


Asp Met Asp Asn Asn Gly Lys Glu Glu Ser Lys Ile Asp His Leu Xaa 
                645                 650                 655     


Asn Asn Arg Asn Asp Leu Ile Ser Lys Glu Glu Gln Asn Ser Ser Ser 
            660                 665                 670         


Leu Leu Glu Glu Asn Lys Val His Ala Asp Leu Val Ile Ser Lys Pro 
        675                 680                 685             


Val Ser Lys Ser Pro Glu Arg Leu Arg Lys Asp Ile Glu Val Leu Ser 
    690                 695                 700                 


Glu Asp Xaa Asp Tyr Glu Glu Asp Glu Val Xaa Lys Lys Arg Lys Asp 
705                 710                 715                 720 


Val Lys Lys Asp Xaa Xaa Asp Lys Ser Ser Lys Pro Gln Ile Lys Arg 
                725                 730                 735     


Gly Lys Arg Arg Tyr Cys Asn Xaa Glu Glu Cys Leu Lys Xaa Gly Ser 
            740                 745                 750         


Pro Gly Lys Lys Glu Glu Lys Ala Lys Asn Lys Glu Ser Leu Cys Met 
        755                 760                 765             


Glu Asn Ser Ser Asn Ser Ser Ser Asp Glu Asp Glu Glu Glu Xaa Lys 
    770                 775                 780                 


Ala Lys Met Xaa Pro Xaa Lys Lys Tyr Asn Gly Leu Glu Glu Lys Arg 
785                 790                 795                 800 


Lys Ser Leu Arg Xaa Xaa Gly Phe Tyr Ser Gly Phe Ser Glu Val Ala 
                805                 810                 815     


Glu Lys Arg Ile Lys Leu Leu Asn Asn Ser Asp Glu Arg Leu Gln Asn 
            820                 825                 830         


Ser Arg Ala Lys Asp Arg Lys Asp Val Trp Ser Ser Ile Gln Gly Gln 
        835                 840                 845             


Trp Pro Lys Lys Xaa Leu Lys Glu Leu Phe Ser Asp Ser Asp Xaa Glu 
    850                 855                 860                 


Ala Ala Ala Ser Pro Pro His Pro Ala Pro Glu Glu Gly Val Ala Glu 
865                 870                 875                 880 


Glu Ser Leu Gln Xaa Val Ala Glu Glu Glu Ser Cys Ser Pro Ser Val 
                885                 890                 895     


Glu Leu Glu Lys Pro Pro Pro Val Asn Val Asp Ser Lys Pro Ile Glu 
            900                 905                 910         


Glu Lys Xaa Val Glu Val Asn Asp Arg Lys Ala Glu Phe Pro Ser Ser 
        915                 920                 925             


Gly Ser Asn Ser Val Leu Asn Xaa Pro Pro Xaa Xaa Pro Glu Ser Pro 
    930                 935                 940                 


Ser Ser Val Xaa Val Xaa Glu Gly Ser Arg Gln Gln Ser Ser Val Xaa 
945                 950                 955                 960 


Val Ser Glu Pro Leu Ala Pro Asn Gln Glu Glu Val Arg Ser Ile Lys 
                965                 970                 975     


Ser Glu Xaa Asp Ser Xaa Ile Glu Val Asp Ser Val Ala Gly Glu Leu 
            980                 985                 990         


Gln Asp Leu Gln Ser Glu Gly Asn  Ser Ser Pro Ala Gly  Phe Asp Ala 
        995                 1000                 1005             


Ser Val  Ser Ser Ser Ser Ser  Asn Gln Pro Glu Pro  Glu His Pro 
    1010                 1015                 1020             


Glu Lys  Ala Cys Xaa Gly Gln  Lys Arg Val Lys Asp  Ala Gln Gly 
    1025                 1030                 1035             


Gly Gly  Ser Ser Ser Lys Lys  Gln Lys Arg Ser His  Lys Ala Xaa 
    1040                 1045                 1050             


Val Val  Asn Asn Lys Lys Lys  Gly Lys Gly Xaa Asn  Ser Ser Asp 
    1055                 1060                 1065             


Ser Glu  Glu Leu Ser Ala Gly  Glu Ser Ile Xaa Lys  Ser Gln Pro 
    1070                 1075                 1080             


Val Lys  Ser Val Ser Xaa Gly  Met Lys Ser His Ser  Xaa Lys Ser 
    1085                 1090                 1095             


Pro Ala  Arg Xaa Gln Ser Pro  Gly Lys Cys Gly Lys  Asn Gly Asp 
    1100                 1105                 1110             


Lys Asp  Pro Asp Leu Lys Glu  Pro Ser Asn Arg Leu  Pro Lys Val 
    1115                 1120                 1125             


Tyr Lys  Trp Ser Phe Gln Met  Ser Asp Leu Glu Asn  Met Xaa Ser 
    1130                 1135                 1140             


Ala Glu  Arg Ile Xaa Ile Leu  Gln Glu Lys Leu Gln  Glu Ile Arg 
    1145                 1150                 1155             


Lys His  Tyr Leu Ser Leu Lys  Ser Glu Val Ala Ser  Ile Asp Arg 
    1160                 1165                 1170             


Arg Arg  Lys Arg Leu Lys Lys  Lys Glu Arg Glu Ser  Ala Ala Xaa 
    1175                 1180                 1185             


Ser Ser  Ser Ser Ser Ser Pro  Ser Ser Ser Ser Ile  Xaa Ala Ala 
    1190                 1195                 1200             


Val Met  Leu Xaa Leu Ala Glu  Pro Ser Met Ser Ser  Ala Ser Gln 
    1205                 1210                 1215             


Asn Gly  Met Ser Val Glu Cys  Arg 
    1220                 1225     


<210> 3144
<211> 1312
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1234)..(1234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1287)..(1287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1293)..(1293)
<223> Selenocysteine

<400> 3144
Met Lys Ala Leu Asp Glu Pro Pro Tyr Leu Xaa Val Gly Xaa Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Xaa Ala 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Xaa Phe Arg His Asp Ser Ser Xaa 
        35                  40                  45              


Val Glu Val Gln Asp Asp His Ile Lys Gly Pro Leu Lys Val Gly Ala 
    50                  55                  60                  


Ile Val Glu Val Lys Asn Leu Asp Gly Ala Tyr Gln Glu Ala Val Ile 
65                  70                  75                  80  


Asn Lys Leu Xaa Asp Ala Ser Trp Tyr Xaa Val Val Phe Asp Asp Gly 
                85                  90                  95      


Asp Glu Lys Xaa Leu Arg Arg Ser Ser Leu Cys Leu Lys Gly Glu Arg 
            100                 105                 110         


His Phe Ala Glu Ser Glu Xaa Leu Asp Gln Leu Pro Leu Xaa Asn Pro 
        115                 120                 125             


Glu His Phe Gly Xaa Pro Val Ile Gly Lys Lys Xaa Asn Arg Gly Arg 
    130                 135                 140                 


Arg Ser Asn His Ile Pro Glu Glu Glu Ser Ser Ser Ser Ser Ser Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Asp Arg Lys Gln Ile Asp Glu Leu Leu Gly Lys Val 
                165                 170                 175     


Val Cys Val Asp Tyr Ile Ser Leu Asp Lys Lys Lys Ala Leu Trp Phe 
            180                 185                 190         


Pro Ala Leu Val Val Cys Pro Asp Cys Ser Asp Glu Ile Ala Val Lys 
        195                 200                 205             


Lys Asp Asn Ile Leu Val Arg Ser Phe Lys Asp Gly Lys Phe Xaa Ser 
    210                 215                 220                 


Val Pro Arg Lys Asp Val His Glu Ile Xaa Ser Asp Xaa Ala Pro Lys 
225                 230                 235                 240 


Pro Asp Ala Val Leu Lys Gln Ala Phe Glu Gln Ala Leu Glu Phe His 
                245                 250                 255     


Lys Ser Arg Xaa Ile Pro Ala Asn Trp Lys Xaa Glu Leu Lys Glu Asp 
            260                 265                 270         


Ser Ser Ser Ser Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu 
        275                 280                 285             


Lys Glu Lys Glu Asp Asn Ser Ser Glu Glu Glu Glu Glu Ile Glu Pro 
    290                 295                 300                 


Phe Pro Glu Glu Arg Glu Asn Phe Leu Gln Gln Leu Tyr Lys Phe Met 
305                 310                 315                 320 


Glu Asp Arg Gly Xaa Pro Ile Asn Lys Arg Pro Val Leu Gly Tyr Arg 
                325                 330                 335     


Asn Leu Asn Leu Phe Lys Leu Phe Arg Leu Val His Lys Leu Gly Gly 
            340                 345                 350         


Phe Asp Asn Ile Glu Ser Gly Ala Val Trp Lys Gln Val Tyr Gln Asp 
        355                 360                 365             


Leu Gly Ile Pro Val Leu Asn Ser Ala Ala Gly Tyr Asn Val Lys Cys 
    370                 375                 380                 


Ala Tyr Lys Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys Arg Ser Ala 
385                 390                 395                 400 


Asn Ile Glu Phe Gln Met Ala Leu Pro Glu Lys Val Val Asn Lys Gln 
                405                 410                 415     


Cys Lys Glu Cys Glu Asn Val Lys Glu Ile Lys Val Lys Glu Glu Asn 
            420                 425                 430         


Glu Xaa Glu Ile Lys Glu Ile Lys Met Glu Glu Glu Arg Asn Ile Ile 
        435                 440                 445             


Pro Arg Glu Glu Lys Pro Ile Glu Asp Glu Ile Glu Arg Lys Glu Asn 
    450                 455                 460                 


Ile Lys Pro Ser Leu Gly Ser Lys Lys Asn Leu Leu Glu Ser Ile Pro 
465                 470                 475                 480 


Xaa His Ser Asp Gln Glu Lys Glu Val Asn Ile Lys Lys Pro Glu Asp 
                485                 490                 495     


Asn Glu Asn Leu Asp Asp Lys Asp Asp Asp Xaa Xaa Arg Val Asp Glu 
            500                 505                 510         


Ser Leu Asn Ile Lys Val Glu Ala Glu Glu Glu Lys Ala Lys Ser Gly 
        515                 520                 525             


Asp Glu Xaa Asn Lys Glu Glu Asp Glu Asp Asp Glu Glu Ala Glu Glu 
    530                 535                 540                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Asp Asp Asp Asn 
545                 550                 555                 560 


Asn Glu Glu Glu Glu Phe Glu Cys Tyr Pro Pro Gly Met Lys Val Gln 
                565                 570                 575     


Val Arg Tyr Gly Arg Gly Lys Asn Gln Lys Met Tyr Glu Ala Ser Ile 
            580                 585                 590         


Lys Asp Ser Asp Val Glu Gly Gly Glu Val Leu Tyr Leu Val His Tyr 
        595                 600                 605             


Cys Gly Trp Asn Val Arg Tyr Asp Glu Trp Ile Lys Ala Asp Lys Ile 
    610                 615                 620                 


Val Arg Pro Ala Asp Lys Asn Val Pro Lys Ile Lys His Arg Lys Lys 
625                 630                 635                 640 


Ile Lys Asn Lys Leu Asp Lys Glu Lys Asp Lys Asp Glu Lys Tyr Ser 
                645                 650                 655     


Pro Lys Asn Cys Lys Leu Arg Arg Leu Ser Lys Pro Pro Phe Gln Xaa 
            660                 665                 670         


Asn Pro Ser Pro Glu Met Val Ser Lys Leu Asp Leu Xaa Asp Ala Lys 
        675                 680                 685             


Asn Ser Asp Xaa Ala His Ile Lys Ser Ile Glu Ile Xaa Ser Ile Leu 
    690                 695                 700                 


Asn Gly Leu Gln Ala Ser Glu Ser Ser Ala Glu Asp Ser Glu Gln Glu 
705                 710                 715                 720 


Asp Glu Arg Gly Ala Gln Asp Met Asp Asn Asn Gly Lys Glu Glu Ser 
                725                 730                 735     


Lys Ile Asp His Leu Xaa Asn Asn Arg Asn Asp Leu Ile Ser Lys Glu 
            740                 745                 750         


Glu Gln Asn Ser Ser Ser Leu Leu Glu Glu Asn Lys Val His Ala Asp 
        755                 760                 765             


Leu Val Ile Ser Lys Pro Val Ser Lys Ser Pro Glu Arg Leu Arg Lys 
    770                 775                 780                 


Asp Ile Glu Val Leu Ser Glu Asp Xaa Asp Tyr Glu Glu Asp Glu Val 
785                 790                 795                 800 


Xaa Lys Lys Arg Lys Asp Val Lys Lys Asp Xaa Xaa Asp Lys Ser Ser 
                805                 810                 815     


Lys Pro Gln Ile Lys Arg Gly Lys Arg Arg Tyr Cys Asn Xaa Glu Glu 
            820                 825                 830         


Cys Leu Lys Xaa Gly Ser Pro Gly Lys Lys Glu Glu Lys Ala Lys Asn 
        835                 840                 845             


Lys Glu Ser Leu Cys Met Glu Asn Ser Ser Asn Ser Ser Ser Asp Glu 
    850                 855                 860                 


Asp Glu Glu Glu Xaa Lys Ala Lys Met Xaa Pro Xaa Lys Lys Tyr Asn 
865                 870                 875                 880 


Gly Leu Glu Glu Lys Arg Lys Ser Leu Arg Xaa Xaa Gly Phe Tyr Ser 
                885                 890                 895     


Gly Phe Ser Glu Val Ala Glu Lys Arg Ile Lys Leu Leu Asn Asn Ser 
            900                 905                 910         


Asp Glu Arg Leu Gln Asn Ser Arg Ala Lys Asp Arg Lys Asp Val Trp 
        915                 920                 925             


Ser Ser Ile Gln Gly Gln Trp Pro Lys Lys Xaa Leu Lys Glu Leu Phe 
    930                 935                 940                 


Ser Asp Ser Asp Xaa Glu Ala Ala Ala Ser Pro Pro His Pro Ala Pro 
945                 950                 955                 960 


Glu Glu Gly Val Ala Glu Glu Ser Leu Gln Xaa Val Ala Glu Glu Glu 
                965                 970                 975     


Ser Cys Ser Pro Ser Val Glu Leu Glu Lys Pro Pro Pro Val Asn Val 
            980                 985                 990         


Asp Ser Lys Pro Ile Glu Glu Lys  Xaa Val Glu Val Asn  Asp Arg Lys 
        995                 1000                 1005             


Ala Glu  Phe Pro Ser Ser Gly  Ser Asn Ser Val Leu  Asn Xaa Pro 
    1010                 1015                 1020             


Pro Xaa  Xaa Pro Glu Ser Pro  Ser Ser Val Xaa Val  Xaa Glu Gly 
    1025                 1030                 1035             


Ser Arg  Gln Gln Ser Ser Val  Xaa Val Ser Glu Pro  Leu Ala Pro 
    1040                 1045                 1050             


Asn Gln  Glu Glu Val Arg Ser  Ile Lys Ser Glu Xaa  Asp Ser Xaa 
    1055                 1060                 1065             


Ile Glu  Val Asp Ser Val Ala  Gly Glu Leu Gln Asp  Leu Gln Ser 
    1070                 1075                 1080             


Glu Gly  Asn Ser Ser Pro Ala  Gly Phe Asp Ala Ser  Val Ser Ser 
    1085                 1090                 1095             


Ser Ser  Ser Asn Gln Pro Glu  Pro Glu His Pro Glu  Lys Ala Cys 
    1100                 1105                 1110             


Xaa Gly  Gln Lys Arg Val Lys  Asp Ala Gln Gly Gly  Gly Ser Ser 
    1115                 1120                 1125             


Ser Lys  Lys Gln Lys Arg Ser  His Lys Ala Xaa Val  Val Asn Asn 
    1130                 1135                 1140             


Lys Lys  Lys Gly Lys Gly Xaa  Asn Ser Ser Asp Ser  Glu Glu Leu 
    1145                 1150                 1155             


Ser Ala  Gly Glu Ser Ile Xaa  Lys Ser Gln Pro Val  Lys Ser Val 
    1160                 1165                 1170             


Ser Xaa  Gly Met Lys Ser His  Ser Xaa Lys Ser Pro  Ala Arg Xaa 
    1175                 1180                 1185             


Gln Ser  Pro Gly Lys Cys Gly  Lys Asn Gly Asp Lys  Asp Pro Asp 
    1190                 1195                 1200             


Leu Lys  Glu Pro Ser Asn Arg  Leu Pro Lys Val Tyr  Lys Trp Ser 
    1205                 1210                 1215             


Phe Gln  Met Ser Asp Leu Glu  Asn Met Xaa Ser Ala  Glu Arg Ile 
    1220                 1225                 1230             


Xaa Ile  Leu Gln Glu Lys Leu  Gln Glu Ile Arg Lys  His Tyr Leu 
    1235                 1240                 1245             


Ser Leu  Lys Ser Glu Val Ala  Ser Ile Asp Arg Arg  Arg Lys Arg 
    1250                 1255                 1260             


Leu Lys  Lys Lys Glu Arg Glu  Ser Ala Ala Xaa Ser  Ser Ser Ser 
    1265                 1270                 1275             


Ser Ser  Pro Ser Ser Ser Ser  Ile Xaa Ala Ala Val  Met Leu Xaa 
    1280                 1285                 1290             


Leu Ala  Glu Pro Ser Met Ser  Ser Ala Ser Gln Asn  Gly Met Ser 
    1295                 1300                 1305             


Val Glu  Cys Arg 
    1310         


<210> 3145
<211> 553
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<400> 3145
Xaa Phe Glu Cys Tyr Pro Pro Gly Met Lys Val Gln Val Arg Tyr Asp 
1               5                   10                  15      


Glu Trp Ile Lys Ala Asp Lys Ile Val Arg Pro Ala Asp Lys Asn Val 
            20                  25                  30          


Pro Lys Ile Lys His Arg Lys Lys Ile Lys Asn Lys Leu Asp Lys Glu 
        35                  40                  45              


Lys Asp Lys Asp Glu Lys Tyr Ser Pro Lys Asn Cys Lys Leu Arg Arg 
    50                  55                  60                  


Leu Ser Lys Pro Pro Phe Gln Xaa Asn Pro Ser Pro Glu Met Val Ser 
65                  70                  75                  80  


Lys Leu Asp Leu Xaa Asp Ala Lys Asn Ser Asp Xaa Ala His Ile Lys 
                85                  90                  95      


Ser Ile Glu Ile Xaa Ser Ile Leu Asn Gly Leu Gln Ala Ser Glu Ser 
            100                 105                 110         


Ser Ala Glu Asp Ser Glu Gln Glu Asp Glu Arg Gly Ala Gln Asp Met 
        115                 120                 125             


Asp Asn Asn Gly Lys Glu Glu Ser Lys Ile Asp His Leu Xaa Asn Asn 
    130                 135                 140                 


Arg Asn Asp Leu Ile Ser Lys Glu Glu Gln Asn Ser Ser Ser Leu Leu 
145                 150                 155                 160 


Glu Glu Asn Lys Val His Ala Asp Leu Val Ile Ser Lys Pro Val Ser 
                165                 170                 175     


Lys Ser Pro Glu Arg Leu Arg Lys Asp Ile Glu Val Leu Ser Glu Asp 
            180                 185                 190         


Xaa Asp Tyr Glu Glu Asp Glu Val Xaa Lys Lys Arg Lys Asp Val Lys 
        195                 200                 205             


Lys Asp Xaa Xaa Asp Lys Ser Ser Lys Pro Gln Ile Lys Arg Gly Lys 
    210                 215                 220                 


Arg Arg Tyr Cys Asn Xaa Glu Glu Cys Leu Lys Xaa Gly Ser Pro Gly 
225                 230                 235                 240 


Lys Lys Glu Glu Lys Ala Lys Asn Lys Glu Ser Leu Cys Met Glu Asn 
                245                 250                 255     


Ser Ser Asn Ser Ser Ser Asp Glu Asp Glu Glu Glu Xaa Lys Ala Lys 
            260                 265                 270         


Met Xaa Pro Xaa Lys Lys Tyr Asn Gly Leu Glu Glu Lys Arg Lys Ser 
        275                 280                 285             


Leu Arg Xaa Xaa Gly Phe Tyr Ser Gly Phe Ser Glu Val Ala Glu Lys 
    290                 295                 300                 


Arg Ile Lys Leu Leu Asn Asn Ser Asp Glu Arg Leu Gln Asn Ser Arg 
305                 310                 315                 320 


Ala Lys Asp Arg Lys Asp Val Trp Ser Ser Ile Gln Gly Gln Trp Pro 
                325                 330                 335     


Lys Lys Xaa Leu Lys Glu Leu Phe Ser Asp Ser Asp Xaa Glu Ala Ala 
            340                 345                 350         


Ala Ser Pro Pro His Pro Ala Pro Glu Glu Gly Val Ala Glu Glu Ser 
        355                 360                 365             


Leu Gln Xaa Val Ala Glu Glu Glu Ser Cys Ser Pro Ser Val Glu Leu 
    370                 375                 380                 


Glu Lys Pro Pro Pro Val Asn Val Asp Ser Lys Pro Ile Glu Glu Lys 
385                 390                 395                 400 


Xaa Val Glu Val Asn Asp Arg Lys Ala Glu Phe Pro Ser Ser Gly Ser 
                405                 410                 415     


Asn Ser Val Leu Asn Xaa Pro Pro Xaa Xaa Pro Glu Ser Pro Ser Ser 
            420                 425                 430         


Val Xaa Val Xaa Glu Gly Ser Arg Gln Gln Ser Ser Val Xaa Val Ser 
        435                 440                 445             


Glu Pro Leu Ala Pro Asn Gln Glu Glu Val Arg Ser Ile Lys Ser Glu 
    450                 455                 460                 


Xaa Asp Ser Xaa Ile Glu Val Asp Ser Val Ala Gly Glu Leu Gln Asp 
465                 470                 475                 480 


Leu Gln Ser Glu Gly Asn Ser Ser Pro Ala Gly Phe Asp Ala Ser Val 
                485                 490                 495     


Ser Ser Ser Ser Ser Asn Gln Pro Glu Pro Glu His Pro Glu Lys Ala 
            500                 505                 510         


Cys Xaa Gly Gln Lys Arg Val Lys Asp Ala Gln Gly Gly Gly Ser Ser 
        515                 520                 525             


Ser Lys Lys Gln Lys Arg Ser His Lys Ala Xaa Val Val Asn Asn Lys 
    530                 535                 540                 


Lys Lys Gly Lys Gly Ser Lys Cys Glu 
545                 550             


<210> 3146
<211> 696
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<400> 3146
Xaa Lys Asn Ser Asp Xaa Ala His Ile Lys Ser Ile Glu Ile Xaa Ser 
1               5                   10                  15      


Ile Leu Asn Gly Leu Gln Ala Ser Glu Ser Ser Ala Glu Asp Ser Glu 
            20                  25                  30          


Gln Glu Asp Glu Arg Gly Ala Gln Asp Met Asp Asn Asn Gly Lys Glu 
        35                  40                  45              


Glu Ser Lys Ile Asp His Leu Xaa Asn Asn Arg Asn Asp Leu Ile Ser 
    50                  55                  60                  


Lys Glu Glu Gln Asn Ser Ser Ser Leu Leu Glu Glu Asn Lys Val His 
65                  70                  75                  80  


Ala Asp Leu Val Ile Ser Lys Pro Val Ser Lys Ser Pro Glu Arg Leu 
                85                  90                  95      


Arg Lys Asp Ile Glu Val Leu Ser Glu Asp Xaa Asp Tyr Glu Glu Asp 
            100                 105                 110         


Glu Val Xaa Lys Lys Arg Lys Asp Val Lys Lys Asp Xaa Xaa Asp Lys 
        115                 120                 125             


Ser Ser Lys Pro Gln Ile Lys Arg Gly Lys Arg Arg Tyr Cys Asn Xaa 
    130                 135                 140                 


Glu Glu Cys Leu Lys Xaa Gly Ser Pro Gly Lys Lys Glu Glu Lys Ala 
145                 150                 155                 160 


Lys Asn Lys Glu Ser Leu Cys Met Glu Asn Ser Ser Asn Ser Ser Ser 
                165                 170                 175     


Asp Glu Asp Glu Glu Glu Xaa Lys Ala Lys Met Xaa Pro Xaa Lys Lys 
            180                 185                 190         


Tyr Asn Gly Leu Glu Glu Lys Arg Lys Ser Leu Arg Xaa Xaa Gly Phe 
        195                 200                 205             


Tyr Ser Gly Phe Ser Glu Val Ala Glu Lys Arg Ile Lys Leu Leu Asn 
    210                 215                 220                 


Asn Ser Asp Glu Arg Leu Gln Asn Ser Arg Ala Lys Asp Arg Lys Asp 
225                 230                 235                 240 


Val Trp Ser Ser Ile Gln Gly Gln Trp Pro Lys Lys Xaa Leu Lys Glu 
                245                 250                 255     


Leu Phe Ser Asp Ser Asp Xaa Glu Ala Ala Ala Ser Pro Pro His Pro 
            260                 265                 270         


Ala Pro Glu Glu Gly Val Ala Glu Glu Ser Leu Gln Xaa Val Ala Glu 
        275                 280                 285             


Glu Glu Ser Cys Ser Pro Ser Val Glu Leu Glu Lys Pro Pro Pro Val 
    290                 295                 300                 


Asn Val Asp Ser Lys Pro Ile Glu Glu Lys Xaa Val Glu Val Asn Asp 
305                 310                 315                 320 


Arg Lys Ala Glu Phe Pro Ser Ser Gly Ser Asn Ser Val Leu Asn Xaa 
                325                 330                 335     


Pro Pro Xaa Xaa Pro Glu Ser Pro Ser Ser Val Xaa Val Xaa Glu Gly 
            340                 345                 350         


Ser Arg Gln Gln Ser Ser Val Xaa Val Ser Glu Pro Leu Ala Pro Asn 
        355                 360                 365             


Gln Glu Glu Val Arg Ser Ile Lys Ser Glu Xaa Asp Ser Xaa Ile Glu 
    370                 375                 380                 


Val Asp Ser Val Ala Gly Glu Leu Gln Asp Leu Gln Ser Glu Gly Asn 
385                 390                 395                 400 


Ser Ser Pro Ala Gly Phe Asp Ala Ser Val Ser Ser Ser Ser Ser Asn 
                405                 410                 415     


Gln Pro Glu Pro Glu His Pro Glu Lys Ala Cys Xaa Gly Gln Lys Arg 
            420                 425                 430         


Val Lys Asp Ala Gln Gly Gly Gly Ser Ser Ser Lys Lys Gln Lys Arg 
        435                 440                 445             


Ser His Lys Ala Xaa Val Val Asn Asn Lys Lys Lys Gly Lys Gly Xaa 
    450                 455                 460                 


Asn Ser Ser Asp Ser Glu Glu Leu Ser Ala Gly Glu Ser Ile Xaa Lys 
465                 470                 475                 480 


Ser Gln Pro Val Lys Ser Val Ser Xaa Gly Met Lys Ser His Ser Xaa 
                485                 490                 495     


Lys Ser Pro Ala Arg Xaa Gln Ser Pro Gly Lys Cys Gly Lys Asn Gly 
            500                 505                 510         


Asp Lys Asp Pro Asp Leu Lys Glu Pro Ser Asn Arg Leu Pro Lys Val 
        515                 520                 525             


Tyr Lys Trp Ser Phe Gln Met Ser Asp Leu Glu Asn Met Xaa Ser Ala 
    530                 535                 540                 


Glu Arg Ile Xaa Ile Leu Gln Glu Lys Leu Gln Glu Ile Arg Lys His 
545                 550                 555                 560 


Tyr Leu Ser Leu Lys Ser Glu Val Ala Ser Ile Asp Arg Arg Arg Lys 
                565                 570                 575     


Arg Leu Lys Lys Lys Glu Arg Glu Ser Ala Ala Xaa Ser Ser Ser Ser 
            580                 585                 590         


Ser Ser Pro Ser Ser Ser Ser Ile Xaa Ala Ala Val Met Leu Xaa Leu 
        595                 600                 605             


Ala Glu Pro Ser Met Ser Ser Ala Ser Gln Asn Gly Met Leu Gln Pro 
    610                 615                 620                 


Leu Pro Glu Asp Val Leu His Ser Gln Asn Glu Ala Phe Leu Lys Arg 
625                 630                 635                 640 


Arg Gly Pro Pro Xaa Asp Gly Asp Lys Pro Ala Pro Ser Pro Ser Ala 
                645                 650                 655     


Ser Leu Arg Arg Arg Pro Ala Ala Asp Cys Arg Arg Gly Gly Gly Val 
            660                 665                 670         


Ala Arg Glu Arg Lys Cys Pro Glu Pro Gly Ser Ala Ser Trp Arg Ala 
        675                 680                 685             


Ala Ala Val Trp Glu Ser Leu Glu 
    690                 695     


<210> 3147
<211> 594
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<400> 3147
Met Ala Ala Pro Val Lys Gly Asn Arg Lys Gln Ser Xaa Glu Gly Asp 
1               5                   10                  15      


Ala Leu Asp Pro Pro Ala Ser Pro Lys Pro Ala Gly Lys Gln Asn Gly 
            20                  25                  30          


Ile Gln Asn Pro Ile Ser Leu Glu Asp Ser Pro Glu Ala Gly Gly Glu 
        35                  40                  45              


Arg Glu Glu Glu Gln Glu Arg Glu Glu Glu Gln Ala Phe Leu Val Ser 
    50                  55                  60                  


Leu Tyr Lys Phe Met Lys Glu Arg His Xaa Pro Ile Glu Arg Val Pro 
65                  70                  75                  80  


His Leu Gly Phe Lys Gln Ile Asn Leu Trp Lys Ile Tyr Lys Ala Val 
                85                  90                  95      


Glu Lys Leu Gly Ala Tyr Glu Leu Val Xaa Gly Arg Arg Leu Trp Lys 
            100                 105                 110         


Asn Val Tyr Asp Glu Leu Gly Gly Ser Pro Gly Ser Xaa Ser Ala Ala 
        115                 120                 125             


Xaa Cys Xaa Arg Arg His Tyr Glu Arg Leu Val Leu Pro Tyr Val Arg 
    130                 135                 140                 


His Leu Lys Gly Glu Asp Asp Lys Pro Leu Pro Xaa Ser Lys Pro Arg 
145                 150                 155                 160 


Lys Gln Tyr Lys Met Ala Lys Glu Asn Arg Gly Asp Asp Gly Ala Xaa 
                165                 170                 175     


Glu Arg Pro Lys Lys Ala Lys Glu Glu Arg Arg Met Asp Gln Met Met 
            180                 185                 190         


Pro Gly Lys Xaa Lys Ala Asp Ala Ala Asp Pro Ala Pro Leu Pro Ser 
        195                 200                 205             


Gln Glu Pro Pro Arg Asn Ser Xaa Glu Gln Gln Gly Leu Ala Ser Gly 
    210                 215                 220                 


Ser Ser Val Ser Phe Val Gly Ala Ser Gly Cys Pro Glu Ala Tyr Lys 
225                 230                 235                 240 


Arg Leu Leu Ser Ser Phe Tyr Cys Lys Gly Xaa His Gly Ile Met Ser 
                245                 250                 255     


Pro Leu Ala Lys Lys Lys Leu Leu Ala Gln Val Ser Lys Val Glu Ala 
            260                 265                 270         


Leu Gln Cys Gln Glu Glu Gly Cys Arg His Gly Ala Glu Pro Gln Ala 
        275                 280                 285             


Ser Pro Ala Val His Leu Pro Glu Ser Pro Gln Ser Pro Lys Gly Leu 
    290                 295                 300                 


Xaa Glu Asn Ser Arg His Arg Leu Xaa Pro Gln Glu Gly Leu Gln Ala 
305                 310                 315                 320 


Pro Gly Gly Ser Leu Arg Glu Glu Ala Gln Ala Gly Pro Cys Pro Ala 
                325                 330                 335     


Ala Pro Ile Phe Lys Gly Cys Phe Tyr Xaa His Pro Xaa Glu Val Leu 
            340                 345                 350         


Lys Pro Val Ser Gln His Pro Arg Asp Phe Phe Ser Arg Leu Lys Asp 
        355                 360                 365             


Gly Val Leu Leu Gly Pro Pro Gly Lys Glu Gly Leu Ser Val Lys Glu 
    370                 375                 380                 


Pro Gln Leu Val Trp Gly Gly Asp Ala Asn Arg Pro Ser Ala Phe His 
385                 390                 395                 400 


Lys Gly Gly Ser Arg Lys Gly Ile Leu Tyr Pro Lys Pro Lys Ala Cys 
                405                 410                 415     


Trp Val Ser Pro Met Ala Lys Val Pro Ala Glu Ser Pro Xaa Leu Pro 
            420                 425                 430         


Pro Xaa Phe Pro Ser Ser Pro Gly Leu Gly Ser Lys Arg Ser Leu Glu 
        435                 440                 445             


Glu Glu Gly Ala Ala His Ser Gly Lys Arg Leu Arg Ala Val Ser Pro 
    450                 455                 460                 


Phe Leu Lys Glu Ala Asp Ala Lys Lys Cys Gly Ala Lys Pro Ala Gly 
465                 470                 475                 480 


Ser Gly Leu Val Ser Cys Leu Leu Gly Pro Ala Leu Gly Pro Val Pro 
                485                 490                 495     


Pro Glu Ala Tyr Arg Gly Xaa Met Leu His Cys Pro Leu Asn Phe Xaa 
            500                 505                 510         


Gly Xaa Pro Gly Pro Leu Lys Gly Gln Ala Ala Leu Pro Phe Ser Pro 
        515                 520                 525             


Leu Val Ile Pro Ala Phe Pro Ala His Phe Leu Ala Xaa Ala Gly Pro 
    530                 535                 540                 


Ser Pro Met Ala Ala Gly Leu Met His Phe Pro Pro Xaa Ser Phe Asp 
545                 550                 555                 560 


Ser Ala Leu Arg His Arg Leu Cys Pro Ala Ser Ser Ala Trp His Ala 
                565                 570                 575     


Pro Pro Val Xaa Xaa Tyr Ala Ala Pro His Phe Phe His Leu Asn Xaa 
            580                 585                 590         


Lys Leu 
        


<210> 3148
<211> 58
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<400> 3148
Met Ala Ala Pro Val Lys Gly Asn Arg Lys Gln Ser Xaa Glu Gly Asp 
1               5                   10                  15      


Ala Leu Asp Pro Pro Ala Ser Pro Lys Pro Ala Gly Lys Gln Asn Gly 
            20                  25                  30          


Ile Gln Asn Pro Ile Ser Leu Glu Leu Xaa Cys Gly Arg Ser Xaa Lys 
        35                  40                  45              


Gln Trp Arg Ser Trp Gly Pro Met Ser Trp 
    50                  55              


<210> 3149
<211> 526
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<400> 3149
Met Lys Glu Arg His Xaa Pro Ile Glu Arg Val Pro His Leu Gly Phe 
1               5                   10                  15      


Lys Gln Ile Asn Leu Trp Lys Ile Tyr Lys Ala Val Glu Lys Leu Gly 
            20                  25                  30          


Ala Tyr Glu Leu Val Xaa Gly Arg Arg Leu Trp Lys Asn Val Tyr Asp 
        35                  40                  45              


Glu Leu Gly Gly Ser Pro Gly Ser Xaa Ser Ala Ala Xaa Cys Xaa Arg 
    50                  55                  60                  


Arg His Tyr Glu Arg Leu Val Leu Pro Tyr Val Arg His Leu Lys Gly 
65                  70                  75                  80  


Glu Asp Asp Lys Pro Leu Pro Xaa Ser Lys Pro Arg Lys Gln Tyr Lys 
                85                  90                  95      


Met Ala Lys Glu Asn Arg Gly Asp Asp Gly Ala Xaa Glu Arg Pro Lys 
            100                 105                 110         


Lys Ala Lys Glu Glu Arg Arg Met Asp Gln Met Met Pro Gly Lys Xaa 
        115                 120                 125             


Lys Ala Asp Ala Ala Asp Pro Ala Pro Leu Pro Ser Gln Glu Pro Pro 
    130                 135                 140                 


Arg Asn Ser Xaa Glu Gln Gln Gly Leu Ala Ser Gly Ser Ser Val Ser 
145                 150                 155                 160 


Phe Val Gly Ala Ser Gly Cys Pro Glu Ala Tyr Lys Arg Leu Leu Ser 
                165                 170                 175     


Ser Phe Tyr Cys Lys Gly Xaa His Gly Ile Met Ser Pro Leu Ala Lys 
            180                 185                 190         


Lys Lys Leu Leu Ala Gln Val Ser Lys Val Glu Ala Leu Gln Cys Gln 
        195                 200                 205             


Glu Glu Gly Cys Arg His Gly Ala Glu Pro Gln Ala Ser Pro Ala Val 
    210                 215                 220                 


His Leu Pro Glu Ser Pro Gln Ser Pro Lys Gly Leu Xaa Glu Asn Ser 
225                 230                 235                 240 


Arg His Arg Leu Xaa Pro Gln Glu Gly Leu Gln Ala Pro Gly Gly Ser 
                245                 250                 255     


Leu Arg Glu Glu Ala Gln Ala Gly Pro Cys Pro Ala Ala Pro Ile Phe 
            260                 265                 270         


Lys Gly Cys Phe Tyr Xaa His Pro Xaa Glu Val Leu Lys Pro Val Ser 
        275                 280                 285             


Gln His Pro Arg Asp Phe Phe Ser Arg Leu Lys Asp Gly Val Leu Leu 
    290                 295                 300                 


Gly Pro Pro Gly Lys Glu Gly Leu Ser Val Lys Glu Pro Gln Leu Val 
305                 310                 315                 320 


Trp Gly Gly Asp Ala Asn Arg Pro Ser Ala Phe His Lys Gly Gly Ser 
                325                 330                 335     


Arg Lys Gly Ile Leu Tyr Pro Lys Pro Lys Ala Cys Trp Val Ser Pro 
            340                 345                 350         


Met Ala Lys Val Pro Ala Glu Ser Pro Xaa Leu Pro Pro Xaa Phe Pro 
        355                 360                 365             


Ser Ser Pro Gly Leu Gly Ser Lys Arg Ser Leu Glu Glu Glu Gly Ala 
    370                 375                 380                 


Ala His Ser Gly Lys Arg Leu Arg Ala Val Ser Pro Phe Leu Lys Glu 
385                 390                 395                 400 


Ala Asp Ala Lys Lys Cys Gly Ala Lys Pro Ala Gly Ser Gly Leu Val 
                405                 410                 415     


Ser Cys Leu Leu Gly Pro Ala Leu Gly Pro Val Pro Pro Glu Ala Tyr 
            420                 425                 430         


Arg Gly Xaa Met Leu His Cys Pro Leu Asn Phe Xaa Gly Xaa Pro Gly 
        435                 440                 445             


Pro Leu Lys Gly Gln Ala Ala Leu Pro Phe Ser Pro Leu Val Ile Pro 
    450                 455                 460                 


Ala Phe Pro Ala His Phe Leu Ala Xaa Ala Gly Pro Ser Pro Met Ala 
465                 470                 475                 480 


Ala Gly Leu Met His Phe Pro Pro Xaa Ser Phe Asp Ser Ala Leu Arg 
                485                 490                 495     


His Arg Leu Cys Pro Ala Ser Ser Ala Trp His Ala Pro Pro Val Xaa 
            500                 505                 510         


Xaa Tyr Ala Ala Pro His Phe Phe His Leu Asn Xaa Lys Leu 
        515                 520                 525     


<210> 3150
<211> 945
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<400> 3150
Met Ala Pro Asn Leu Lys Gly Arg Pro Arg Lys Lys Lys Pro Cys Pro 
1               5                   10                  15      


Gln Arg Arg Asp Ser Phe Ser Gly Val Lys Asp Ser Asn Asn Asn Ser 
            20                  25                  30          


Asp Gly Lys Ala Val Ala Lys Val Lys Cys Glu Ala Arg Ser Ala Leu 
        35                  40                  45              


Xaa Lys Pro Lys Asn Asn His Asn Cys Lys Lys Val Ser Asn Glu Glu 
    50                  55                  60                  


Lys Pro Lys Val Ala Ile Gly Glu Glu Cys Arg Ala Asp Glu Gln Ala 
65                  70                  75                  80  


Phe Leu Val Ala Leu Tyr Lys Tyr Met Lys Glu Arg Lys Xaa Pro Ile 
                85                  90                  95      


Glu Arg Ile Pro Tyr Leu Gly Phe Lys Gln Ile Asn Leu Trp Xaa Met 
            100                 105                 110         


Phe Gln Ala Ala Gln Lys Leu Gly Gly Tyr Glu Xaa Ile Xaa Ala Arg 
        115                 120                 125             


Arg Gln Trp Lys His Ile Tyr Asp Glu Leu Gly Gly Asn Pro Gly Ser 
    130                 135                 140                 


Xaa Ser Ala Ala Xaa Cys Xaa Arg Arg His Tyr Glu Arg Leu Ile Leu 
145                 150                 155                 160 


Pro Tyr Glu Arg Phe Ile Lys Gly Glu Glu Asp Lys Pro Leu Pro Pro 
                165                 170                 175     


Ile Lys Pro Arg Lys Gln Glu Asn Ser Ser Gln Glu Asn Glu Asn Lys 
            180                 185                 190         


Xaa Lys Val Ser Gly Xaa Lys Arg Ile Lys His Glu Ile Pro Lys Ser 
        195                 200                 205             


Lys Lys Glu Lys Glu Asn Ala Pro Lys Pro Gln Asp Ala Ala Glu Val 
    210                 215                 220                 


Ser Ser Glu Gln Glu Lys Glu Gln Glu Xaa Leu Ile Ser Gln Lys Ser 
225                 230                 235                 240 


Ile Pro Glu Pro Leu Pro Ala Ala Asp Met Lys Lys Lys Ile Glu Gly 
                245                 250                 255     


Tyr Gln Glu Phe Ser Ala Lys Pro Leu Ala Ser Arg Val Asp Pro Glu 
            260                 265                 270         


Lys Asp Asn Glu Xaa Asp Gln Gly Ser Asn Ser Glu Lys Val Ala Glu 
        275                 280                 285             


Glu Ala Gly Glu Lys Gly Pro Xaa Pro Pro Leu Pro Ser Ala Pro Leu 
    290                 295                 300                 


Ala Pro Glu Lys Asp Ser Ala Leu Val Pro Gly Ala Ser Lys Gln Pro 
305                 310                 315                 320 


Leu Xaa Ser Pro Ser Ala Leu Val Asp Ser Lys Gln Glu Ser Lys Leu 
                325                 330                 335     


Cys Cys Phe Xaa Glu Ser Pro Glu Ser Glu Pro Gln Glu Ala Ser Phe 
            340                 345                 350         


Pro Ser Phe Pro Xaa Xaa Gln Pro Pro Leu Ala Asn Gln Asn Glu Xaa 
        355                 360                 365             


Glu Asp Asp Lys Leu Pro Ala Met Ala Asp Tyr Ile Ala Asn Cys Xaa 
    370                 375                 380                 


Val Lys Val Asp Gln Leu Gly Ser Asp Asp Ile His Asn Ala Leu Lys 
385                 390                 395                 400 


Gln Xaa Pro Lys Val Leu Val Val Gln Ser Phe Asp Met Phe Lys Asp 
                405                 410                 415     


Lys Asp Leu Xaa Gly Pro Met Asn Glu Asn His Gly Leu Asn Tyr Xaa 
            420                 425                 430         


Pro Leu Leu Tyr Ser Arg Gly Asn Pro Gly Ile Met Ser Pro Leu Ala 
        435                 440                 445             


Lys Lys Lys Leu Leu Ser Gln Val Ser Gly Ala Ser Leu Ser Ser Ser 
    450                 455                 460                 


Tyr Pro Tyr Gly Ser Pro Pro Pro Leu Ile Ser Lys Lys Lys Leu Ile 
465                 470                 475                 480 


Ala Arg Asp Asp Leu Cys Ser Ser Leu Ser Gln Xaa His His Gly Gln 
                485                 490                 495     


Ser Xaa Asp His Met Ala Val Ser Arg Pro Ser Val Ile Gln His Val 
            500                 505                 510         


Gln Ser Phe Arg Ser Lys Pro Ser Glu Glu Arg Lys Xaa Ile Asn Asp 
        515                 520                 525             


Ile Phe Lys His Glu Lys Leu Ser Arg Ser Asp Pro His Arg Cys Ser 
    530                 535                 540                 


Phe Ser Lys His His Leu Asn Pro Leu Ala Asp Ser Tyr Val Leu Lys 
545                 550                 555                 560 


Gln Glu Ile Gln Glu Gly Lys Asp Lys Leu Leu Glu Lys Arg Ala Leu 
                565                 570                 575     


Pro His Ser His Met Pro Ser Phe Leu Ala Asp Phe Tyr Ser Ser Pro 
            580                 585                 590         


His Leu His Ser Leu Tyr Arg His Xaa Glu His His Leu His Asn Glu 
        595                 600                 605             


Gln Xaa Ser Lys Tyr Pro Ser Arg Asp Met Tyr Arg Glu Ser Glu Asn 
    610                 615                 620                 


Ser Ser Phe Pro Ser His Arg His Gln Glu Lys Leu His Val Asn Tyr 
625                 630                 635                 640 


Leu Xaa Ser Leu His Leu Gln Asp Lys Lys Ser Ala Ala Ala Glu Ala 
                645                 650                 655     


Pro Xaa Asp Asp Gln Pro Xaa Asp Leu Ser Leu Pro Lys Asn Pro His 
            660                 665                 670         


Lys Pro Xaa Gly Lys Val Leu Gly Leu Ala His Ser Xaa Xaa Gly Pro 
        675                 680                 685             


Gln Glu Ser Lys Gly Ile Ser Gln Phe Gln Val Leu Gly Ser Gln Ser 
    690                 695                 700                 


Arg Asp Cys His Pro Lys Ala Cys Arg Val Ser Pro Met Xaa Met Ser 
705                 710                 715                 720 


Gly Pro Lys Lys Tyr Pro Glu Ser Leu Ser Arg Ser Gly Lys Pro His 
                725                 730                 735     


His Val Arg Leu Glu Asn Phe Arg Lys Met Glu Gly Met Val His Pro 
            740                 745                 750         


Ile Leu His Arg Lys Met Ser Pro Gln Asn Ile Gly Ala Ala Arg Pro 
        755                 760                 765             


Ile Lys Arg Ser Leu Glu Asp Leu Asp Leu Val Ile Ala Gly Lys Lys 
    770                 775                 780                 


Ala Arg Ala Val Ser Pro Leu Asp Pro Ser Lys Glu Val Ser Gly Lys 
785                 790                 795                 800 


Glu Lys Ala Ser Glu Gln Glu Ser Glu Gly Ser Lys Ala Ala His Gly 
                805                 810                 815     


Gly His Ser Gly Gly Gly Ser Glu Gly His Lys Leu Pro Leu Ser Ser 
            820                 825                 830         


Pro Ile Phe Pro Gly Leu Tyr Ser Gly Ser Leu Cys Asn Ser Gly Leu 
        835                 840                 845             


Asn Ser Arg Leu Pro Ala Gly Tyr Ser His Ser Leu Gln Tyr Leu Lys 
    850                 855                 860                 


Asn Gln Xaa Val Leu Ser Pro Leu Met Gln Pro Leu Ala Phe His Ser 
865                 870                 875                 880 


Leu Val Met Gln Arg Gly Ile Phe Xaa Ser Pro Xaa Asn Ser Gln Gln 
                885                 890                 895     


Leu Tyr Arg His Leu Ala Ala Ala Xaa Pro Val Gly Ser Ser Tyr Gly 
            900                 905                 910         


Asp Leu Leu His Asn Ser Ile Tyr Pro Leu Ala Ala Ile Asn Pro Gln 
        915                 920                 925             


Ala Ala Phe Pro Ser Ser Gln Leu Ser Ser Val His Pro Ser Xaa Lys 
    930                 935                 940                 


Leu 
945 


<210> 3151
<211> 1188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<400> 3151
Met Glu Pro Asn Ser Leu Gln Trp Val Gly Ser Pro Cys Gly Leu His 
1               5                   10                  15      


Gly Pro Tyr Ile Phe Tyr Lys Ala Phe Gln Phe His Leu Glu Gly Lys 
            20                  25                  30          


Pro Arg Ile Leu Ser Leu Gly Asp Phe Phe Phe Val Arg Cys Xaa Pro 
        35                  40                  45              


Lys Asp Pro Ile Cys Ile Ala Glu Leu Gln Leu Leu Trp Glu Glu Arg 
    50                  55                  60                  


Xaa Ser Arg Gln Leu Leu Ser Ser Ser Lys Leu Tyr Phe Leu Pro Glu 
65                  70                  75                  80  


Asp Xaa Pro Gln Gly Arg Asn Ser Asp His Gly Glu Asp Glu Val Ile 
                85                  90                  95      


Ala Val Ser Glu Lys Val Ile Val Lys Leu Glu Asp Leu Val Lys Trp 
            100                 105                 110         


Val His Ser Asp Phe Ser Lys Trp Arg Cys Gly Phe His Ala Gly Pro 
        115                 120                 125             


Val Lys Xaa Glu Ala Leu Gly Arg Asn Gly Gln Lys Glu Ala Leu Leu 
    130                 135                 140                 


Lys Tyr Arg Gln Ser Xaa Leu Asn Ser Gly Leu Asn Phe Lys Asp Val 
145                 150                 155                 160 


Leu Lys Glu Lys Ala Asp Leu Gly Glu Asp Glu Glu Glu Xaa Asn Val 
                165                 170                 175     


Ile Val Leu Ser Tyr Pro Gln Tyr Cys Arg Tyr Arg Ser Met Leu Lys 
            180                 185                 190         


Arg Ile Gln Asp Lys Pro Ser Ser Ile Leu Xaa Asp Gln Phe Ala Leu 
        195                 200                 205             


Ala Leu Gly Gly Ile Ala Val Val Ser Arg Asn Pro Gln Ile Leu Tyr 
    210                 215                 220                 


Cys Arg Asp Xaa Phe Asp His Pro Xaa Leu Ile Glu Asn Glu Ser Ile 
225                 230                 235                 240 


Cys Asp Glu Phe Ala Pro Asn Leu Lys Gly Arg Pro Arg Lys Lys Lys 
                245                 250                 255     


Pro Cys Pro Gln Arg Arg Asp Ser Phe Ser Gly Val Lys Asp Ser Asn 
            260                 265                 270         


Asn Asn Ser Asp Gly Lys Ala Val Ala Lys Val Lys Cys Glu Ala Arg 
        275                 280                 285             


Ser Ala Leu Xaa Lys Pro Lys Asn Asn His Asn Cys Lys Lys Val Ser 
    290                 295                 300                 


Asn Glu Glu Lys Pro Lys Val Ala Ile Gly Glu Glu Cys Arg Ala Asp 
305                 310                 315                 320 


Glu Gln Ala Phe Leu Val Ala Leu Tyr Lys Tyr Met Lys Glu Arg Lys 
                325                 330                 335     


Xaa Pro Ile Glu Arg Ile Pro Tyr Leu Gly Phe Lys Gln Ile Asn Leu 
            340                 345                 350         


Trp Xaa Met Phe Gln Ala Ala Gln Lys Leu Gly Gly Tyr Glu Xaa Ile 
        355                 360                 365             


Xaa Ala Arg Arg Gln Trp Lys His Ile Tyr Asp Glu Leu Gly Gly Asn 
    370                 375                 380                 


Pro Gly Ser Xaa Ser Ala Ala Xaa Cys Xaa Arg Arg His Tyr Glu Arg 
385                 390                 395                 400 


Leu Ile Leu Pro Tyr Glu Arg Phe Ile Lys Gly Glu Glu Asp Lys Pro 
                405                 410                 415     


Leu Pro Pro Ile Lys Pro Arg Lys Gln Glu Asn Ser Ser Gln Glu Asn 
            420                 425                 430         


Glu Asn Lys Xaa Lys Val Ser Gly Xaa Lys Arg Ile Lys His Glu Ile 
        435                 440                 445             


Pro Lys Ser Lys Lys Glu Lys Glu Asn Ala Pro Lys Pro Gln Asp Ala 
    450                 455                 460                 


Ala Glu Val Ser Ser Glu Gln Glu Lys Glu Gln Glu Xaa Leu Ile Ser 
465                 470                 475                 480 


Gln Lys Ser Ile Pro Glu Pro Leu Pro Ala Ala Asp Met Lys Lys Lys 
                485                 490                 495     


Ile Glu Gly Tyr Gln Glu Phe Ser Ala Lys Pro Leu Ala Ser Arg Val 
            500                 505                 510         


Asp Pro Glu Lys Asp Asn Glu Xaa Asp Gln Gly Ser Asn Ser Glu Lys 
        515                 520                 525             


Val Ala Glu Glu Ala Gly Glu Lys Gly Pro Xaa Pro Pro Leu Pro Ser 
    530                 535                 540                 


Ala Pro Leu Ala Pro Glu Lys Asp Ser Ala Leu Val Pro Gly Ala Ser 
545                 550                 555                 560 


Lys Gln Pro Leu Xaa Ser Pro Ser Ala Leu Val Asp Ser Lys Gln Glu 
                565                 570                 575     


Ser Lys Leu Cys Cys Phe Xaa Glu Ser Pro Glu Ser Glu Pro Gln Glu 
            580                 585                 590         


Ala Ser Phe Pro Ser Phe Pro Xaa Xaa Gln Pro Pro Leu Ala Asn Gln 
        595                 600                 605             


Asn Glu Xaa Glu Asp Asp Lys Leu Pro Ala Met Ala Asp Tyr Ile Ala 
    610                 615                 620                 


Asn Cys Xaa Val Lys Val Asp Gln Leu Gly Ser Asp Asp Ile His Asn 
625                 630                 635                 640 


Ala Leu Lys Gln Xaa Pro Lys Val Leu Val Val Gln Ser Phe Asp Met 
                645                 650                 655     


Phe Lys Asp Lys Asp Leu Xaa Gly Pro Met Asn Glu Asn His Gly Leu 
            660                 665                 670         


Asn Tyr Xaa Pro Leu Leu Tyr Ser Arg Gly Asn Pro Gly Ile Met Ser 
        675                 680                 685             


Pro Leu Ala Lys Lys Lys Leu Leu Ser Gln Val Ser Gly Ala Ser Leu 
    690                 695                 700                 


Ser Ser Ser Tyr Pro Tyr Gly Ser Pro Pro Pro Leu Ile Ser Lys Lys 
705                 710                 715                 720 


Lys Leu Ile Ala Arg Asp Asp Leu Cys Ser Ser Leu Ser Gln Xaa His 
                725                 730                 735     


His Gly Gln Ser Xaa Asp His Met Ala Val Ser Arg Pro Ser Val Ile 
            740                 745                 750         


Gln His Val Gln Ser Phe Arg Ser Lys Pro Ser Glu Glu Arg Lys Xaa 
        755                 760                 765             


Ile Asn Asp Ile Phe Lys His Glu Lys Leu Ser Arg Ser Asp Pro His 
    770                 775                 780                 


Arg Cys Ser Phe Ser Lys His His Leu Asn Pro Leu Ala Asp Ser Tyr 
785                 790                 795                 800 


Val Leu Lys Gln Glu Ile Gln Glu Gly Lys Asp Lys Leu Leu Glu Lys 
                805                 810                 815     


Arg Ala Leu Pro His Ser His Met Pro Ser Phe Leu Ala Asp Phe Tyr 
            820                 825                 830         


Ser Ser Pro His Leu His Ser Leu Tyr Arg His Xaa Glu His His Leu 
        835                 840                 845             


His Asn Glu Gln Xaa Ser Lys Tyr Pro Ser Arg Asp Met Tyr Arg Glu 
    850                 855                 860                 


Ser Glu Asn Ser Ser Phe Pro Ser His Arg His Gln Glu Lys Leu His 
865                 870                 875                 880 


Val Asn Tyr Leu Xaa Ser Leu His Leu Gln Asp Lys Lys Ser Ala Ala 
                885                 890                 895     


Ala Glu Ala Pro Xaa Asp Asp Gln Pro Xaa Asp Leu Ser Leu Pro Lys 
            900                 905                 910         


Asn Pro His Lys Pro Xaa Gly Lys Val Leu Gly Leu Ala His Ser Xaa 
        915                 920                 925             


Xaa Gly Pro Gln Glu Ser Lys Gly Ile Ser Gln Phe Gln Val Leu Gly 
    930                 935                 940                 


Ser Gln Ser Arg Asp Cys His Pro Lys Ala Cys Arg Val Ser Pro Met 
945                 950                 955                 960 


Xaa Met Ser Gly Pro Lys Lys Tyr Pro Glu Ser Leu Ser Arg Ser Gly 
                965                 970                 975     


Lys Pro His His Val Arg Leu Glu Asn Phe Arg Lys Met Glu Gly Met 
            980                 985                 990         


Val His Pro Ile Leu His Arg Lys  Met Ser Pro Gln Asn  Ile Gly Ala 
        995                 1000                 1005             


Ala Arg  Pro Ile Lys Arg Ser  Leu Glu Asp Leu Asp  Leu Val Ile 
    1010                 1015                 1020             


Ala Gly  Lys Lys Ala Arg Ala  Val Ser Pro Leu Asp  Pro Ser Lys 
    1025                 1030                 1035             


Glu Val  Ser Gly Lys Glu Lys  Ala Ser Glu Gln Glu  Ser Glu Gly 
    1040                 1045                 1050             


Ser Lys  Ala Ala His Gly Gly  His Ser Gly Gly Gly  Ser Glu Gly 
    1055                 1060                 1065             


His Lys  Leu Pro Leu Ser Ser  Pro Ile Phe Pro Gly  Leu Tyr Ser 
    1070                 1075                 1080             


Gly Ser  Leu Cys Asn Ser Gly  Leu Asn Ser Arg Leu  Pro Ala Gly 
    1085                 1090                 1095             


Tyr Ser  His Ser Leu Gln Tyr  Leu Lys Asn Gln Xaa  Val Leu Ser 
    1100                 1105                 1110             


Pro Leu  Met Gln Pro Leu Ala  Phe His Ser Leu Val  Met Gln Arg 
    1115                 1120                 1125             


Gly Ile  Phe Xaa Ser Pro Xaa  Asn Ser Gln Gln Leu  Tyr Arg His 
    1130                 1135                 1140             


Leu Ala  Ala Ala Xaa Pro Val  Gly Ser Ser Tyr Gly  Asp Leu Leu 
    1145                 1150                 1155             


His Asn  Ser Ile Tyr Pro Leu  Ala Ala Ile Asn Pro  Gln Ala Ala 
    1160                 1165                 1170             


Phe Pro  Ser Ser Gln Leu Ser  Ser Val His Pro Ser  Xaa Lys Leu 
    1175                 1180                 1185             


<210> 3152
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 3152
Met Ala Ile Gly Phe Asn Val Glu Xaa Val Xaa Tyr Lys Asn Leu Lys 
1               5                   10                  15      


Phe Gln Val Trp Asp Leu Gly Gly Gln Xaa Ser Ile Arg Pro Tyr Trp 
            20                  25                  30          


Arg Cys Tyr Tyr Ser Asn Xaa Asp Ala Val Ile Tyr Val Val Asp Ser 
        35                  40                  45              


Cys Asp Arg Asp Arg Ile Gly Ile Ser Lys Ser Glu Leu Val Ala Met 
    50                  55                  60                  


Leu Glu Glu Glu Glu Leu Arg Lys Ala Ile Leu Val Val Phe Ala Asn 
65                  70                  75                  80  


Lys Gln Asp Met Glu Gln Ala Met Xaa Ser Ser Glu Met Ala Asn Ser 
                85                  90                  95      


Leu Gly Leu Pro Ala Leu Lys Asp Arg Lys Trp Gln Ile Phe Lys Xaa 
            100                 105                 110         


Ser Ala Xaa Lys Gly Xaa Gly Leu Asp Glu Ala Met Glu Trp Leu Val 
        115                 120                 125             


Glu Xaa Leu Lys Ser Arg Gln 
    130                 135 


<210> 3153
<211> 52
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<400> 3153
Met Glu Gln Ala Met Xaa Ser Ser Glu Met Ala Asn Ser Leu Gly Leu 
1               5                   10                  15      


Pro Ala Leu Lys Asp Arg Lys Trp Gln Ile Phe Lys Xaa Ser Ala Xaa 
            20                  25                  30          


Lys Gly Xaa Gly Leu Asp Glu Ala Met Glu Trp Leu Val Glu Xaa Leu 
        35                  40                  45              


Lys Ser Arg Gln 
    50          


<210> 3154
<211> 64
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<400> 3154
Met Gly Gly Phe Phe Ser Ser Ile Phe Ser Ser Leu Phe Gly Xaa Arg 
1               5                   10                  15      


Glu Met Arg Ile Leu Ile Leu Gly Leu Asp Gly Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Arg Leu Gln Val Gly Glu Val Val Xaa Xaa Ile Pro Lys 
        35                  40                  45              


Leu Leu Ala Phe Lys Lys Tyr Pro Glu Asp Gly Ile Asp Leu Ala Asn 
    50                  55                  60                  


<210> 3155
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<400> 3155
Met Gly Gly Phe Phe Ser Ser Ile Phe Ser Ser Leu Phe Gly Xaa Arg 
1               5                   10                  15      


Glu Met Arg Ile Leu Ile Leu Gly Leu Asp Gly Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Arg Leu Gln Val Gly Glu Val Val Xaa Xaa Ile Pro Xaa 
        35                  40                  45              


Ile Gly Phe Asn Val Glu Xaa Val Xaa Tyr Lys Asn Leu Lys Phe Gln 
    50                  55                  60                  


Val Trp Asp Leu Gly Gly Gln Xaa Ser Ile Arg Pro Tyr Trp Arg Cys 
65                  70                  75                  80  


Tyr Tyr Ser Asn Xaa Asp Ala Val Ile Tyr Val Val Asp Ser Cys Asp 
                85                  90                  95      


Arg Asp Arg Ile Gly Ile Ser Lys Ser Glu Leu Val Ala Met Leu Glu 
            100                 105                 110         


Glu Glu Glu Leu Arg Lys Ala Ile Leu Val Val Phe Ala Asn Lys Gln 
        115                 120                 125             


Asp Met Glu Gln Ala Met Xaa Ser Ser Glu Met Ala Asn Ser Leu Gly 
    130                 135                 140                 


Leu Pro Ala Leu Lys Asp Arg Lys Trp Gln Ile Phe Lys Xaa Ser Ala 
145                 150                 155                 160 


Xaa Lys Gly Xaa Gly Leu Asp Glu Ala Met Glu Trp Leu Val Glu Xaa 
                165                 170                 175     


Leu Lys Ser Arg Gln 
            180     


<210> 3156
<211> 194
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<400> 3156
Met Gly Gly Phe Phe Ser Ser Ile Phe Ser Ser Leu Phe Gly Xaa Arg 
1               5                   10                  15      


Glu Met Arg Ile Leu Ile Leu Gly Leu Asp Gly Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Arg Leu Gln Val Gly Glu Val Val Xaa Xaa Ile Pro Xaa 
        35                  40                  45              


Ile Gly Phe Asn Val Glu Xaa Val Xaa Tyr Lys Asn Leu Lys Phe Gln 
    50                  55                  60                  


Val Trp Asp Leu Gly Gly Gln Xaa Ser Ile Arg Pro Tyr Trp Arg Cys 
65                  70                  75                  80  


Tyr Tyr Ser Asn Xaa Asp Ala Val Ile Tyr Val Val Asp Ser Cys Asp 
                85                  90                  95      


Arg Asp Arg Ile Gly Ile Ser Lys Ser Glu Leu Val Ala Met Leu Glu 
            100                 105                 110         


Glu Glu Glu Leu Arg Lys Ala Ile Leu Val Val Phe Ala Asn Lys Gln 
        115                 120                 125             


Asp Met Glu Gln Ala Met Xaa Ser Ser Glu Met Ala Asn Ser Leu Gly 
    130                 135                 140                 


Leu Pro Ala Leu Lys Asp Arg Lys Trp Gln Ile Phe Lys Xaa Ser Ala 
145                 150                 155                 160 


Xaa Lys Gly Xaa Gly Leu Asp Glu Ala Met Glu Trp Gln Val Ser Cys 
                165                 170                 175     


Phe Gln Lys Pro Ser Val His Leu Cys Val Leu Ala Ala Met His Val 
            180                 185                 190         


His Val 
        


<210> 3157
<211> 17
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<400> 3157
Met Arg Ile Leu Ile Leu Gly Leu Asp Gly Ala Gly Lys Xaa Xaa Ile 
1               5                   10                  15      


Leu 
    


<210> 3158
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<400> 3158
Met Arg Ile Leu Ile Leu Gly Leu Asp Gly Ala Gly Lys Xaa Xaa Ile 
1               5                   10                  15      


Leu Tyr Arg Leu Gln Val Gly Glu Val Val Xaa Xaa Ile Pro Xaa Ile 
            20                  25                  30          


Gly Phe Asn Val Glu Xaa Val Xaa Tyr Lys Asn Leu Lys Phe Gln Val 
        35                  40                  45              


Trp Asp Leu Gly Gly Gln Xaa Ser Ile Arg Pro Tyr Trp Arg Cys Tyr 
    50                  55                  60                  


Tyr Ser Asn Xaa Asp Ala Val Ile Tyr Val Val Asp Ser Cys Asp Arg 
65                  70                  75                  80  


Asp Arg Ile Gly Ile Ser Lys Ser Glu Leu Val Ala Met Leu Glu Glu 
                85                  90                  95      


Glu Glu Leu Arg Lys Ala Ile Leu Val Val Phe Ala Asn Lys Gln Asp 
            100                 105                 110         


Met Glu Gln Ala Met Xaa Ser Ser Glu Met Ala Asn Ser Leu Gly Leu 
        115                 120                 125             


Pro Ala Leu Lys Asp Arg Lys Trp Gln Ile Phe Lys Xaa Ser Ala Xaa 
    130                 135                 140                 


Lys Gly Xaa Gly Leu Asp Glu Ala Met Glu Trp Leu Val Glu Xaa Leu 
145                 150                 155                 160 


Lys Ser Arg Gln 
                


<210> 3159
<211> 244
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<400> 3159
Met Ala Pro Arg Pro Leu Gly Pro Leu Val Leu Ala Leu Gly Gly Ala 
1               5                   10                  15      


Ala Ala Val Leu Gly Ser Val Leu Phe Ile Leu Trp Lys Xaa Tyr Phe 
            20                  25                  30          


Gly Arg Gly Arg Glu Arg Arg Trp Asp Arg Gly Glu Ala Trp Trp Gly 
        35                  40                  45              


Ala Glu Ala Ala Arg Leu Pro Glu Trp Asp Glu Trp Asp Pro Glu Asp 
    50                  55                  60                  


Glu Glu Asp Glu Glu Pro Ala Leu Glu Glu Leu Glu Gln Arg Glu Val 
65                  70                  75                  80  


Leu Val Leu Gly Leu Asp Gly Ala Gly Lys Ser Xaa Phe Leu Arg Val 
                85                  90                  95      


Leu Ser Gly Lys Pro Pro Leu Glu Gly His Ile Pro Xaa Trp Gly Phe 
            100                 105                 110         


Asn Ser Val Arg Leu Pro Xaa Lys Asp Phe Glu Val Asp Leu Leu Glu 
        115                 120                 125             


Ile Gly Gly Ser Gln Asn Leu Arg Phe Tyr Trp Lys Glu Phe Val Ser 
    130                 135                 140                 


Glu Val Asp Val Leu Val Phe Val Val Asp Ser Ala Asp Arg Leu Arg 
145                 150                 155                 160 


Leu Pro Trp Ala Arg Gln Glu Leu His Lys Leu Leu Asp Lys Asp Pro 
                165                 170                 175     


Asp Leu Pro Val Val Val Val Ala Asn Lys Gln Asp Leu Ser Glu Ala 
            180                 185                 190         


Met Ser Met Gly Glu Leu Gln Arg Glu Leu Gly Leu Gln Ala Ile Asp 
        195                 200                 205             


Asn Gln Arg Glu Val Phe Leu Leu Ala Ala Ser Ile Ala Pro Ala Gly 
    210                 215                 220                 


Pro Xaa Phe Glu Glu Pro Gly Xaa Val His Ile Trp Lys Leu Leu Leu 
225                 230                 235                 240 


Glu Leu Leu Ser 
                


<210> 3160
<211> 79
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 3160
Pro Asp Leu Pro Val Val Val Val Ala Asn Lys Gln Val Leu Pro Tyr 
1               5                   10                  15      


Arg Phe Ser Val Val Pro Gly Met Ser Asp Val Gly Ala Xaa Gly Lys 
            20                  25                  30          


Glu Arg His Arg Gly Ser Val Ile Ser Arg Xaa Val Pro Ala Glu Ala 
        35                  40                  45              


His Gly His Pro Glu Pro Gln Pro Pro His His Ser Ile Arg Gly Ala 
    50                  55                  60                  


Ala Phe Arg Arg Ala Phe Arg Phe Arg Arg Phe Arg Leu Xaa Leu 
65                  70                  75                  


<210> 3161
<211> 48
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 3161
Xaa Ser Glu Val Asp Val Leu Val Phe Val Val Asp Ser Ala Asp Arg 
1               5                   10                  15      


Leu Arg Leu Pro Trp Ala Arg Gln Glu Leu His Lys Leu Leu Asp Lys 
            20                  25                  30          


Asp Pro Asp Leu Pro Val Val Val Val Ala Asn Lys Gln Met Leu Lys 
        35                  40                  45              


<210> 3162
<211> 196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<400> 3162
Met Gly Ser Val Asn Ser Arg Gly His Lys Ala Glu Ala Gln Val Val 
1               5                   10                  15      


Met Met Gly Leu Asp Ser Ala Gly Lys Xaa Xaa Leu Leu Tyr Lys Leu 
            20                  25                  30          


Lys Gly His Gln Leu Val Glu Xaa Leu Pro Xaa Val Gly Phe Asn Val 
        35                  40                  45              


Glu Pro Leu Lys Ala Pro Gly His Val Ser Leu Xaa Leu Trp Asp Val 
    50                  55                  60                  


Gly Gly Gln Ala Pro Leu Arg Ala Ser Trp Lys Asp Tyr Leu Glu Gly 
65                  70                  75                  80  


Xaa Asp Ile Leu Val Tyr Val Leu Asp Ser Xaa Asp Glu Ala Arg Leu 
                85                  90                  95      


Pro Glu Ser Ala Ala Glu Leu Xaa Glu Val Leu Asn Asp Pro Asn Met 
            100                 105                 110         


Ala Gly Val Pro Phe Leu Val Leu Ala Asn Lys Gln Glu Ala Pro Asp 
        115                 120                 125             


Ala Leu Pro Leu Leu Lys Ile Arg Asn Arg Leu Ser Leu Glu Arg Phe 
    130                 135                 140                 


Gln Asp His Cys Trp Glu Leu Arg Gly Cys Ser Ala Leu Xaa Gly Glu 
145                 150                 155                 160 


Gly Leu Pro Glu Ala Leu Gln Ser Leu Trp Ser Leu Leu Lys Ser Arg 
                165                 170                 175     


Ser Cys Met Cys Leu Gln Ala Arg Ala His Gly Ala Glu Arg Gly Asp 
            180                 185                 190         


Ser Lys Arg Ser 
        195     


<210> 3163
<211> 290
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(285)
<223> Selenocysteine

<400> 3163
Met Phe Arg Leu Leu Ser Ser Cys Cys Ser Cys Leu Arg Xaa Xaa Glu 
1               5                   10                  15      


Glu Xaa Arg Arg Asn Val Xaa Ile Pro Ile Ile Gly Leu Asn Asn Ser 
            20                  25                  30          


Gly Lys Xaa Val Leu Val Glu Ala Phe Gln Lys Leu Leu Pro Ser Lys 
        35                  40                  45              


Xaa Asp His Cys Met Lys Ser Glu Leu Xaa Xaa Leu Leu Leu Asp Glu 
    50                  55                  60                  


Tyr Glu Leu Ser Ile Tyr Asp Leu Asn Gly Asp Leu Lys Gly Arg Glu 
65                  70                  75                  80  


Ala Trp Pro Asn Tyr Tyr Ala Gln Ala His Gly Leu Val Phe Val Leu 
                85                  90                  95      


Asp Ser Ser Asp Ile Arg Arg Met Gln Glu Val Lys Ile Ile Leu Xaa 
            100                 105                 110         


His Leu Leu Ser Asp Lys Arg Val Ala Gly Lys Pro Ile Leu Ile Leu 
        115                 120                 125             


Ala Asn Lys Gln Asp Lys Lys Lys Ala Leu Met Pro Cys Asp Ile Ile 
    130                 135                 140                 


Asp Tyr Leu Leu Leu Lys Lys Leu Val Lys Glu Asn Lys Cys Pro Cys 
145                 150                 155                 160 


Arg Val Glu Pro Cys Ser Ala Ile Arg Asn Leu Glu Arg Arg Asn His 
                165                 170                 175     


Gln Pro Ile Val Glu Gly Leu Arg Trp Leu Leu Ala Val Ile Asp Xaa 
            180                 185                 190         


Cys Gln Leu Pro Pro Xaa Ser Ser Ile Ser Ile Ser Lys Asn Asn Xaa 
        195                 200                 205             


Gly Ser Gly Glu Arg Cys Ser Ser His Ser Phe Ser Xaa Arg Xaa Gly 
    210                 215                 220                 


Met Ser Lys Glu Lys Arg Gln His Leu Glu Gln Cys Ser Ile Glu Ala 
225                 230                 235                 240 


Lys Pro Leu Lys Ser Ile Leu Gln Lys Glu Gly Xaa Arg Leu Trp Ser 
                245                 250                 255     


Lys Lys Asn Met Ser Val Xaa Phe Ala Leu Asp Glu Pro Met Lys Glu 
            260                 265                 270         


Gly Glu Cys Ser Arg Arg Met Arg Ala Gln Asn Xaa Xaa Lys Leu Cys 
        275                 280                 285             


Tyr Asn 
    290 


<210> 3164
<211> 256
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<400> 3164
Met Phe Arg Leu Leu Ser Ser Cys Cys Ser Cys Leu Arg Xaa Xaa Glu 
1               5                   10                  15      


Glu Xaa Arg Arg Asn Val Xaa Ile Pro Ile Ile Gly Leu Asn Asn Ser 
            20                  25                  30          


Gly Lys Xaa Val Leu Val Glu Ala Phe Gln Lys Leu Leu Pro Ser Lys 
        35                  40                  45              


Xaa Asp His Cys Met Lys Ser Glu Leu Xaa Xaa Leu Leu Leu Asp Glu 
    50                  55                  60                  


Tyr Glu Leu Ser Ile Tyr Asp Leu Asn Gly Asp Leu Lys Gly Arg Glu 
65                  70                  75                  80  


Ala Trp Pro Asn Tyr Tyr Ala Gln Ala His Gly Leu Val Phe Val Leu 
                85                  90                  95      


Asp Ser Ser Asp Ile Arg Arg Met Gln Glu Val Lys Ile Ile Leu Xaa 
            100                 105                 110         


His Leu Leu Ser Asp Lys Arg Val Ala Gly Lys Pro Ile Leu Ile Leu 
        115                 120                 125             


Ala Asn Lys Gln Asp Lys Lys Lys Ala Leu Met Pro Cys Asp Ile Ile 
    130                 135                 140                 


Asp Tyr Leu Leu Leu Lys Lys Leu Val Lys Glu Asn Lys Cys Pro Cys 
145                 150                 155                 160 


Arg Val Glu Pro Cys Ser Ala Ile Arg Asn Leu Glu Arg Arg Asn His 
                165                 170                 175     


Gln Pro Ile Val Glu Gly Leu Arg Trp Leu Leu Ala Val Ile Asp Xaa 
            180                 185                 190         


Cys Gln Leu Pro Pro Xaa Ser Ser Ile Ser Ile Ser Lys Asn Asn Xaa 
        195                 200                 205             


Gly Ser Gly Glu Arg Cys Ser Ser His Ser Phe Ser Xaa Arg Xaa Gly 
    210                 215                 220                 


Met Ser Lys Glu Lys Arg Gln His Leu Glu Gln Cys Ser Ile Glu Ala 
225                 230                 235                 240 


Lys Pro Leu Lys Ser Ile Leu Gln Pro Ser Asn Gln Ser Tyr Xaa His 
                245                 250                 255     


<210> 3165
<211> 124
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(119)
<223> Selenocysteine

<400> 3165
Xaa Ile Arg Asn Leu Glu Arg Arg Asn His Gln Pro Ile Val Glu Gly 
1               5                   10                  15      


Leu Arg Trp Leu Leu Ala Val Ile Asp Xaa Cys Gln Leu Pro Pro Xaa 
            20                  25                  30          


Ser Ser Ile Ser Ile Ser Lys Asn Asn Xaa Gly Ser Gly Glu Arg Cys 
        35                  40                  45              


Ser Ser His Ser Phe Ser Xaa Arg Xaa Gly Met Ser Lys Glu Lys Arg 
    50                  55                  60                  


Gln His Leu Glu Gln Cys Ser Ile Glu Ala Lys Pro Leu Lys Ser Ile 
65                  70                  75                  80  


Leu Gln Lys Glu Gly Xaa Arg Leu Trp Ser Lys Lys Asn Met Ser Val 
                85                  90                  95      


Xaa Phe Ala Leu Asp Glu Pro Met Lys Glu Gly Glu Cys Ser Arg Arg 
            100                 105                 110         


Met Arg Ala Gln Asn Xaa Xaa Lys Leu Cys Tyr Asn 
        115                 120                 


<210> 3166
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<400> 3166
Xaa Leu Ala Asn Lys Gln Asp Lys Lys Lys Ala Leu Met Pro Cys Asp 
1               5                   10                  15      


Ile Ile Asp Tyr Leu Leu Leu Lys Lys Leu Val Lys Glu Asn Lys Cys 
            20                  25                  30          


Pro Cys Arg Val Glu Pro Cys Ser Ala Ile Arg Asn Leu Glu Arg Arg 
        35                  40                  45              


Asn His Gln Pro Ile Val Glu Gly Leu Arg Trp Leu Leu Ala Val Ile 
    50                  55                  60                  


Asp Xaa Cys Gln Leu Pro Pro Xaa Ser Ser Ile Ser Ile Ser Lys Asn 
65                  70                  75                  80  


Asn Xaa Gly Ser Gly Glu Arg Cys Ser Ser His Ser Phe Ser Xaa Arg 
                85                  90                  95      


Xaa Gly Met Ser Lys Glu Lys Arg Gln His Leu Glu Gln Cys Ser Ile 
            100                 105                 110         


Glu Ala Lys Pro Leu Lys Ser Ile Leu Gln Lys Glu Ala Ile Lys Ser 
        115                 120                 125             


Ile Leu Tyr Ser Leu Arg Gly Ser Arg Arg Val Arg Trp His Pro Leu 
    130                 135                 140                 


Arg Met Lys Xaa Xaa Leu Val Lys Lys Asn Arg Asp Phe Xaa Ser Leu 
145                 150                 155                 160 


Tyr Arg Asp Ala 
                


<210> 3167
<211> 325
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<400> 3167
Met Glu Glu Xaa Lys Glu Ala Met Ser Glu Met Leu Arg His Pro Arg 
1               5                   10                  15      


Ile Ser Gly Lys Pro Ile Leu Val Leu Ala Asn Lys Gln Asp Lys Glu 
            20                  25                  30          


Gly Ala Leu Gly Glu Ala Asp Val Ile Glu Cys Leu Ser Leu Glu Lys 
        35                  40                  45              


Leu Val Asn Glu His Lys Cys Leu Cys Gln Ile Glu Pro Cys Ser Ala 
    50                  55                  60                  


Ile Ser Gly Tyr Gly Lys Lys Ile Asp Lys Ser Ile Lys Lys Gly Leu 
65                  70                  75                  80  


Tyr Trp Leu Leu His Val Ile Ala Arg Asp Phe Asp Ala Leu Asn Glu 
                85                  90                  95      


Arg Ile Gln Lys Glu Xaa Xaa Glu Gln Arg Ala Leu Glu Glu Gln Glu 
            100                 105                 110         


Lys Gln Glu Arg Ala Glu Arg Val Arg Lys Leu Arg Glu Glu Arg Lys 
        115                 120                 125             


Gln Asn Glu Gln Glu Gln Ala Glu Leu Asp Gly Xaa Ser Gly Leu Ala 
    130                 135                 140                 


Glu Leu Asp Pro Glu Pro Xaa Asn Pro Phe Gln Pro Ile Ala Ser Val 
145                 150                 155                 160 


Ile Ile Glu Asn Glu Gly Lys Leu Glu Arg Glu Lys Lys Asn Gln Lys 
                165                 170                 175     


Met Glu Lys Asp Ser Asp Gly Cys His Leu Lys His Lys Met Glu His 
            180                 185                 190         


Glu Gln Ile Glu Xaa Gln Gly Gln Val Asn His Asn Gly Gln Lys Asn 
        195                 200                 205             


Asn Glu Phe Gly Leu Val Glu Asn Tyr Lys Glu Ala Leu Xaa Gln Gln 
    210                 215                 220                 


Leu Lys Asn Glu Asp Glu Xaa Asp Arg Pro Ser Leu Glu Ser Ala Asn 
225                 230                 235                 240 


Gly Lys Lys Lys Xaa Lys Lys Leu Arg Met Lys Arg Asn His Arg Val 
                245                 250                 255     


Glu Pro Leu Asn Ile Asp Asp Cys Ala Pro Glu Ser Pro Xaa Pro Pro 
            260                 265                 270         


Pro Pro Pro Pro Pro Val Gly Trp Gly Xaa Pro Lys Val Xaa Arg Leu 
        275                 280                 285             


Pro Lys Leu Glu Pro Leu Gly Glu Xaa His His Asn Asp Phe Tyr Arg 
    290                 295                 300                 


Lys Pro Leu Pro Pro Leu Ala Val Pro Gln Arg Pro Asn Ser Asp Ala 
305                 310                 315                 320 


His Asp Val Ile Ser 
                325 


<210> 3168
<211> 89
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 3168
Met Phe Ser Leu Met Ala Ser Cys Cys Gly Trp Phe Lys Arg Trp Arg 
1               5                   10                  15      


Glu Pro Val Arg Lys Val Xaa Leu Leu Met Val Gly Leu Asp Asn Ala 
            20                  25                  30          


Gly Lys Xaa Ala Xaa Ala Lys Gly Ile Gln Gly Glu Met Gly Ser Pro 
        35                  40                  45              


Tyr Val Ala Gln Ala Gly Leu Glu Cys Leu Ala Ser Ser Tyr Ser Ser 
    50                  55                  60                  


Ala Leu Ala Ser Lys Ser Ala Gly Ile Xaa Gly Met Ser His His Ala 
65                  70                  75                  80  


Gln Pro Gly Gln Asn Xaa Leu Lys Met 
                85                  


<210> 3169
<211> 428
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<400> 3169
Met Phe Ser Leu Met Ala Ser Cys Cys Gly Trp Phe Lys Arg Trp Arg 
1               5                   10                  15      


Glu Pro Val Arg Lys Val Xaa Leu Leu Met Val Gly Leu Asp Asn Ala 
            20                  25                  30          


Gly Lys Xaa Ala Xaa Ala Lys Gly Ile Gln Gly Glu Tyr Pro Glu Asp 
        35                  40                  45              


Val Ala Pro Xaa Val Gly Phe Ser Lys Ile Asn Leu Arg Gln Gly Lys 
    50                  55                  60                  


Phe Glu Val Xaa Ile Phe Asp Leu Gly Gly Gly Ile Arg Ile Arg Gly 
65                  70                  75                  80  


Ile Trp Lys Asn Tyr Tyr Ala Glu Ser Tyr Gly Val Ile Phe Val Val 
                85                  90                  95      


Asp Ser Ser Asp Glu Glu Arg Met Glu Glu Xaa Lys Glu Ala Met Ser 
            100                 105                 110         


Glu Met Leu Arg His Pro Arg Ile Ser Gly Lys Pro Ile Leu Val Leu 
        115                 120                 125             


Ala Asn Lys Gln Asp Lys Glu Gly Ala Leu Gly Glu Ala Asp Val Ile 
    130                 135                 140                 


Glu Cys Leu Ser Leu Glu Lys Leu Val Asn Glu His Lys Cys Leu Cys 
145                 150                 155                 160 


Gln Ile Glu Pro Cys Ser Ala Ile Ser Gly Tyr Gly Lys Lys Ile Asp 
                165                 170                 175     


Lys Ser Ile Lys Lys Gly Leu Tyr Trp Leu Leu His Val Ile Ala Arg 
            180                 185                 190         


Asp Phe Asp Ala Leu Asn Glu Arg Ile Gln Lys Glu Xaa Xaa Glu Gln 
        195                 200                 205             


Arg Ala Leu Glu Glu Gln Glu Lys Gln Glu Arg Ala Glu Arg Val Arg 
    210                 215                 220                 


Lys Leu Arg Glu Glu Arg Lys Gln Asn Glu Gln Glu Gln Ala Glu Leu 
225                 230                 235                 240 


Asp Gly Xaa Ser Gly Leu Ala Glu Leu Asp Pro Glu Pro Xaa Asn Pro 
                245                 250                 255     


Phe Gln Pro Ile Ala Ser Val Ile Ile Glu Asn Glu Gly Lys Leu Glu 
            260                 265                 270         


Arg Glu Lys Lys Asn Gln Lys Met Glu Lys Asp Ser Asp Gly Cys His 
        275                 280                 285             


Leu Lys His Lys Met Glu His Glu Gln Ile Glu Xaa Gln Gly Gln Val 
    290                 295                 300                 


Asn His Asn Gly Gln Lys Asn Asn Glu Phe Gly Leu Val Glu Asn Tyr 
305                 310                 315                 320 


Lys Glu Ala Leu Xaa Gln Gln Leu Lys Asn Glu Asp Glu Xaa Asp Arg 
                325                 330                 335     


Pro Ser Leu Glu Ser Ala Asn Gly Lys Lys Lys Xaa Lys Lys Leu Arg 
            340                 345                 350         


Met Lys Arg Asn His Arg Val Glu Pro Leu Asn Ile Asp Asp Cys Ala 
        355                 360                 365             


Pro Glu Ser Pro Xaa Pro Pro Pro Pro Pro Pro Pro Val Gly Trp Gly 
    370                 375                 380                 


Xaa Pro Lys Val Xaa Arg Leu Pro Lys Leu Glu Pro Leu Gly Glu Xaa 
385                 390                 395                 400 


His His Asn Asp Phe Tyr Arg Lys Pro Leu Pro Pro Leu Ala Val Pro 
                405                 410                 415     


Gln Arg Pro Asn Ser Asp Ala His Asp Val Ile Ser 
            420                 425             


<210> 3170
<211> 56
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<400> 3170
Met Phe Ser Leu Met Ala Ser Cys Cys Gly Trp Phe Lys Arg Trp Arg 
1               5                   10                  15      


Glu Pro Val Arg Lys Val Xaa Leu Leu Met Val Gly Leu Asp Asn Ala 
            20                  25                  30          


Gly Lys Xaa Ala Xaa Ala Lys Gly Ile Gln Gly Gly Xaa Met Phe Ser 
        35                  40                  45              


Asn Leu Gly Val Trp Lys Glu Asn 
    50                  55      


<210> 3171
<211> 321
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (98)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<400> 3171
Met Phe Ser Leu Met Ala Ser Cys Cys Gly Trp Phe Lys Arg Trp Arg 
1               5                   10                  15      


Glu Pro Val Arg Leu Ala Asn Lys Gln Asp Lys Glu Gly Ala Leu Gly 
            20                  25                  30          


Glu Ala Asp Val Ile Glu Cys Leu Ser Leu Glu Lys Leu Val Asn Glu 
        35                  40                  45              


His Lys Cys Leu Cys Gln Ile Glu Pro Cys Ser Ala Ile Ser Gly Tyr 
    50                  55                  60                  


Gly Lys Lys Ile Asp Lys Ser Ile Lys Lys Gly Leu Tyr Trp Leu Leu 
65                  70                  75                  80  


His Val Ile Ala Arg Asp Phe Asp Ala Leu Asn Glu Arg Ile Gln Lys 
                85                  90                  95      


Glu Xaa Xaa Glu Gln Arg Ala Leu Glu Glu Gln Glu Lys Gln Glu Arg 
            100                 105                 110         


Ala Glu Arg Val Arg Lys Leu Arg Glu Glu Arg Lys Gln Asn Glu Gln 
        115                 120                 125             


Glu Gln Ala Glu Leu Asp Gly Xaa Ser Gly Leu Ala Glu Leu Asp Pro 
    130                 135                 140                 


Glu Pro Xaa Asn Pro Phe Gln Pro Ile Ala Ser Val Ile Ile Glu Asn 
145                 150                 155                 160 


Glu Gly Lys Leu Glu Arg Glu Lys Lys Asn Gln Lys Met Glu Lys Asp 
                165                 170                 175     


Ser Asp Gly Cys His Leu Lys His Lys Met Glu His Glu Gln Ile Glu 
            180                 185                 190         


Xaa Gln Gly Gln Val Asn His Asn Gly Gln Lys Asn Asn Glu Phe Gly 
        195                 200                 205             


Leu Val Glu Asn Tyr Lys Glu Ala Leu Xaa Gln Gln Leu Lys Asn Glu 
    210                 215                 220                 


Asp Glu Xaa Asp Arg Pro Ser Leu Glu Ser Ala Asn Gly Lys Lys Lys 
225                 230                 235                 240 


Xaa Lys Lys Leu Arg Met Lys Arg Asn His Arg Val Glu Pro Leu Asn 
                245                 250                 255     


Ile Asp Asp Cys Ala Pro Glu Ser Pro Xaa Pro Pro Pro Pro Pro Pro 
            260                 265                 270         


Pro Val Gly Trp Gly Xaa Pro Lys Val Xaa Arg Leu Pro Lys Leu Glu 
        275                 280                 285             


Pro Leu Gly Glu Xaa His His Asn Asp Phe Tyr Arg Lys Pro Leu Pro 
    290                 295                 300                 


Pro Leu Ala Val Pro Gln Arg Pro Asn Ser Asp Ala His Asp Val Ile 
305                 310                 315                 320 


Ser 
    


<210> 3172
<211> 192
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<400> 3172
Met Gly Ser Leu Gly Ser Lys Asn Pro Gln Xaa Lys Gln Ala Gln Val 
1               5                   10                  15      


Leu Leu Leu Gly Leu Asp Ser Ala Gly Lys Ser Xaa Leu Leu Tyr Lys 
            20                  25                  30          


Leu Lys Leu Ala Lys Asp Ile Xaa Xaa Ile Pro Xaa Ile Gly Phe Asn 
        35                  40                  45              


Val Glu Met Ile Glu Leu Glu Arg Asn Leu Ser Leu Xaa Val Trp Asp 
    50                  55                  60                  


Val Gly Gly Gln Glu Lys Met Arg Xaa Val Trp Gly Cys Tyr Cys Glu 
65                  70                  75                  80  


Asn Xaa Asp Gly Leu Val Tyr Val Val Asp Ser Xaa Asp Lys Gln Arg 
                85                  90                  95      


Leu Glu Glu Ser Gln Arg Gln Phe Glu His Ile Leu Lys Asn Glu His 
            100                 105                 110         


Ile Lys Asn Val Pro Val Val Leu Leu Ala Asn Lys Gln Asp Met Pro 
        115                 120                 125             


Gly Ala Leu Xaa Ala Glu Asp Ile Xaa Arg Met Phe Lys Val Lys Lys 
    130                 135                 140                 


Leu Cys Ser Asp Arg Asn Trp Tyr Val Gln Pro Cys Cys Ala Leu Xaa 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Gln Gly Phe Arg Lys Leu Xaa Gly Phe Val Lys 
                165                 170                 175     


Ser His Met Lys Ser Arg Gly Asp Xaa Leu Ala Phe Phe Lys Gln Asn 
            180                 185                 190         


<210> 3173
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3173
Met Asp Ala Leu Lys Asp Ser Phe Ser Gln Leu Ile Asn Leu Leu Glu 
1               5                   10                  15      


Glu Lys Asp His Glu Ala Val Arg Met 
            20                  25  


<210> 3174
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<400> 3174
Met Ser Asp Leu Arg Ile Xaa Glu Ala Phe Leu Tyr Met Asp Tyr Leu 
1               5                   10                  15      


Cys Phe Arg Ala Leu Cys Cys Lys Gly Pro Pro Pro Ala Arg Pro Glu 
            20                  25                  30          


Tyr Asp Leu Val Cys Ile Gly Leu Xaa Gly Ser Gly Lys Xaa Ser Leu 
        35                  40                  45              


Leu Ser Lys Leu Cys Ser Glu Ser Pro Asp Asn Val Val Ser Xaa Xaa 
    50                  55                  60                  


Gly Phe Ser Ile Lys Ala Val Pro Phe Gln Asn Ala Ile Leu Asn Val 
65                  70                  75                  80  


Lys Glu Leu Gly Gly Ala Asp Asn Ile Arg Lys Tyr Trp Ser Arg Tyr 
                85                  90                  95      


Tyr Gln Gly Ser Gln Gly Val Ile Phe Val Leu Asp Ser Ala Ser Ser 
            100                 105                 110         


Glu Asp Asp Leu Glu Ala Ala Arg Asn Glu Leu His Ser Ala Leu Gln 
        115                 120                 125             


His Pro Gln Leu Cys Xaa Leu Pro Phe Leu Ile Leu Ala Asn His Gln 
    130                 135                 140                 


Asp Lys Pro Ala Ala Arg Ser Val Gln Glu Ile Lys Lys Tyr Phe Glu 
145                 150                 155                 160 


Leu Glu Pro Leu Ala Arg Gly Lys Arg Trp Ile Leu Gln Pro Cys Ser 
                165                 170                 175     


Leu Asp Asp Met Asp Ala Leu Lys Asp Ser Phe Ser Gln Leu Ile Asn 
            180                 185                 190         


Leu Leu Glu Glu Lys Asp His Glu Ala Val Arg Met 
        195                 200                 


<210> 3175
<211> 158
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<400> 3175
Met Ser Asp Leu Arg Ile Xaa Glu Ala Phe Leu Tyr Met Asp Tyr Leu 
1               5                   10                  15      


Cys Phe Arg Ala Leu Cys Cys Lys Gly Pro Pro Pro Ala Arg Pro Glu 
            20                  25                  30          


Tyr Asp Leu Val Cys Ile Gly Leu Xaa Gly Ser Gly Lys Xaa Ser Leu 
        35                  40                  45              


Leu Ser Lys Leu Cys Ser Glu Ser Pro Asp Asn Val Val Ser Xaa Xaa 
    50                  55                  60                  


Gly Phe Ser Ile Lys Ala Val Pro Phe Gln Asn Ala Ile Leu Asn Val 
65                  70                  75                  80  


Lys Glu Leu Gly Gly Ala Asp Asn Ile Arg Lys Tyr Trp Ser Arg Tyr 
                85                  90                  95      


Tyr Gln Gly Ser Gln Gly Val Ile Phe Val Leu Asp Ser Ala Ser Ser 
            100                 105                 110         


Glu Asp Asp Leu Glu Ala Ala Arg Asn Glu Leu His Ser Ala Leu Gln 
        115                 120                 125             


His Pro Gln Leu Cys Xaa Leu Pro Phe Leu Ile Leu Ala Asn His Gln 
    130                 135                 140                 


Asp Lys Pro Ala Ala Arg Ser Val Gln Glu Lys Ile Gln Asp 
145                 150                 155             


<210> 3176
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<400> 3176
Met Ser Asp Leu Arg Ile Xaa Glu Ala Phe Leu Tyr Met Asp Tyr Leu 
1               5                   10                  15      


Cys Phe Arg Ala Leu Cys Cys Lys Gly Pro Pro Pro Ala Arg Pro Glu 
            20                  25                  30          


Tyr Asp Leu Val Cys Ile Gly Leu Xaa Gly Ser Gly Lys Xaa Ser Leu 
        35                  40                  45              


Leu Ser Lys Leu Cys Ser Glu Ser Pro Asp Asn Val Val Ser Xaa Xaa 
    50                  55                  60                  


Gly Phe Ser Ile Lys Ala Val Pro Phe Gln Asn Ala Ile Leu Asn Val 
65                  70                  75                  80  


Lys Glu Leu Gly Gly Ala Asp Asn Ile Arg Lys Tyr Trp Ser Arg Tyr 
                85                  90                  95      


Tyr Gln Gly Ser Gln Gly Val Ile Phe Val Leu Asp Ser Ala Ser Ser 
            100                 105                 110         


Glu Asp Asp Leu Glu Ala Ala Arg Asn Glu Leu His Ser Ala Leu Gln 
        115                 120                 125             


His Pro Gln Leu Cys Xaa Leu Pro Phe Leu Ile Leu Ala Asn His Gln 
    130                 135                 140                 


Asp Lys Pro Ala Ala Arg Ser Val Gln Glu Leu Lys Lys Tyr Phe Glu 
145                 150                 155                 160 


Leu Glu Pro Leu Ala Arg Gly Lys Arg Trp Ile Leu Gln Pro Cys Ser 
                165                 170                 175     


Leu Asp Asp Met Asp Ala Leu Lys Asp Ser Phe Ser Gln Leu Ile Asn 
            180                 185                 190         


Leu Leu Glu Glu Lys Asp His Glu Ala Val Arg Met 
        195                 200                 


<210> 3177
<211> 173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<400> 3177
Met Cys Leu Leu Leu Gly Ala Xaa Gly Val Gly Lys Xaa Leu Leu Val 
1               5                   10                  15      


Lys Arg Leu Gln Glu Val Ser Ser Arg Asp Gly Lys Gly Asp Leu Gly 
            20                  25                  30          


Glu Pro Pro Pro Xaa Arg Pro Xaa Val Gly Xaa Asn Leu Xaa Asp Ile 
        35                  40                  45              


Val Ala Gln Arg Lys Ile Xaa Ile Arg Glu Leu Gly Gly Cys Met Gly 
    50                  55                  60                  


Pro Ile Trp Ser Ser Tyr Tyr Gly Asn Cys Arg Ser Leu Leu Phe Val 
65                  70                  75                  80  


Met Asp Ala Ser Asp Pro Xaa Gln Leu Ser Ala Ser Cys Val Gln Leu 
                85                  90                  95      


Leu Gly Leu Leu Ser Ala Glu Gln Leu Ala Glu Ala Ser Val Leu Ile 
            100                 105                 110         


Leu Phe Asn Lys Ile Asp Leu Pro Cys Tyr Met Ser Xaa Glu Glu Met 
        115                 120                 125             


Lys Ser Leu Ile Arg Leu Pro Asp Ile Ile Ala Cys Ala Lys Gln Asn 
    130                 135                 140                 


Ile Xaa Xaa Ala Glu Ile Ser Ala Arg Glu Gly Xaa Gly Leu Ala Gly 
145                 150                 155                 160 


Val Leu Ala Trp Leu Gln Ala Xaa His Arg Ala Asn Asp 
                165                 170             


<210> 3178
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 3178
Met Asp Ala Ser Asp Pro Xaa Gln Leu Ser Ala Ser Cys Val Gln Leu 
1               5                   10                  15      


Leu Gly Leu Leu Ser Ala Glu Gln Leu Ala Glu Ala Ser Val Leu Ile 
            20                  25                  30          


Leu Phe Asn Lys Ile Asp Leu Pro Cys Tyr Met Ser Xaa Glu Glu Met 
        35                  40                  45              


Lys Ser Leu Ile Arg Leu Pro Asp Ile Ile Ala Cys Ala Lys Gln Asn 
    50                  55                  60                  


Ile Xaa Xaa Ala Glu Ile Ser Ala Arg Glu Gly Xaa Gly Leu Ala Gly 
65                  70                  75                  80  


Val Leu Ala Trp Leu Gln Ala Xaa His Arg Ala Asn Asp 
                85                  90              


<210> 3179
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<400> 3179
Met Gly Pro Ile Trp Ser Ser Tyr Tyr Gly Asn Cys Arg Ser Leu Leu 
1               5                   10                  15      


Phe Val Met Asp Ala Ser Asp Pro Xaa Gln Leu Ser Ala Ser Cys Val 
            20                  25                  30          


Gln Leu Leu Gly Leu Leu Ser Ala Glu Gln Leu Ala Glu Ala Ser Val 
        35                  40                  45              


Leu Ile Leu Phe Asn Lys Ile Asp Leu Pro Cys Tyr Met Ser Xaa Glu 
    50                  55                  60                  


Glu Met Lys Ser Leu Ile Arg Leu Pro Asp Ile Ile Ala Cys Ala Lys 
65                  70                  75                  80  


Gln Asn Ile Xaa Xaa Ala Glu Ile Ser Ala Arg Glu Gly Xaa Gly Leu 
                85                  90                  95      


Ala Gly Val Leu Ala Trp Leu Gln Ala Xaa His Arg Ala Asn Asp 
            100                 105                 110     


<210> 3180
<211> 197
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<400> 3180
Met Arg Val Ala Gly Gly Arg Ala Leu Ser Arg Gly Ala Glu Leu Arg 
1               5                   10                  15      


Val Pro Gly Gly Ala Lys His Gly Met Cys Leu Leu Leu Gly Ala Xaa 
            20                  25                  30          


Gly Val Gly Lys Xaa Leu Leu Val Lys Arg Leu Gln Glu Val Ser Ser 
        35                  40                  45              


Arg Asp Gly Lys Gly Asp Leu Gly Glu Pro Pro Pro Xaa Arg Pro Xaa 
    50                  55                  60                  


Val Gly Xaa Asn Leu Xaa Asp Ile Val Ala Gln Arg Lys Ile Xaa Ile 
65                  70                  75                  80  


Arg Glu Leu Gly Gly Cys Met Gly Pro Ile Trp Ser Ser Tyr Tyr Gly 
                85                  90                  95      


Asn Cys Arg Ser Leu Leu Phe Val Met Asp Ala Ser Asp Pro Xaa Gln 
            100                 105                 110         


Leu Ser Ala Ser Cys Val Gln Leu Leu Gly Leu Leu Ser Ala Glu Gln 
        115                 120                 125             


Leu Ala Glu Ala Ser Val Leu Ile Leu Phe Asn Lys Ile Asp Leu Pro 
    130                 135                 140                 


Cys Tyr Met Ser Xaa Glu Glu Met Lys Ser Leu Ile Arg Leu Pro Asp 
145                 150                 155                 160 


Ile Ile Ala Cys Ala Lys Gln Asn Ile Xaa Xaa Ala Glu Ile Ser Ala 
                165                 170                 175     


Arg Glu Gly Xaa Gly Leu Ala Gly Val Leu Ala Trp Leu Gln Ala Xaa 
            180                 185                 190         


His Arg Ala Asn Asp 
        195         


<210> 3181
<211> 48
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<400> 3181
Val Gly Xaa Asn Leu Xaa Asp Ile Val Ala Gln Arg Lys Ile Xaa Ile 
1               5                   10                  15      


Arg Glu Leu Gly Gly Cys Met Gly Pro Ile Trp Ser Ser Tyr Tyr Gly 
            20                  25                  30          


Asn Cys Arg Ser Leu Leu Ala Cys Ala Ala Asp Xaa Ser Met Glu Asn 
        35                  40                  45              


<210> 3182
<211> 87
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<400> 3182
Met Gly Asn Ile Phe Glu Lys Leu Phe Lys Ser Leu Leu Gly Lys Lys 
1               5                   10                  15      


Lys Met Arg Ile Leu Ile Leu Ser Leu Asp Xaa Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Xaa Val Pro Ala Val Pro Xaa 
        35                  40                  45              


Val Gly Phe Cys Val Glu Xaa Val Glu Tyr Lys Asn Asn Xaa Phe Ala 
    50                  55                  60                  


Val Trp Asp Val Gly Ser His Phe Lys Ile Arg Pro Leu Trp Gln His 
65                  70                  75                  80  


Phe Phe Gln Asn Xaa Lys Ala 
                85          


<210> 3183
<211> 177
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 3183
Met Gly Asn Ile Phe Glu Lys Leu Phe Lys Ser Leu Leu Gly Lys Lys 
1               5                   10                  15      


Lys Met Arg Ile Leu Ile Leu Ser Leu Asp Xaa Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Xaa Val Pro Ala Val Pro Xaa 
        35                  40                  45              


Val Gly Phe Cys Val Glu Xaa Val Glu Tyr Lys Asn Asn Xaa Phe Ala 
    50                  55                  60                  


Val Trp Asp Val Gly Ser His Phe Lys Ile Arg Pro Leu Trp Gln His 
65                  70                  75                  80  


Phe Phe Gln Asn Xaa Lys Gly Ala Arg Ser Pro Gly Ser Xaa His Gln 
                85                  90                  95      


Gly Ser Leu Ala Ser Gly Val Leu Pro Ile Lys Cys Ser His Val Glu 
            100                 105                 110         


Phe Gly Met Trp Lys Gly Gly Arg Ser His Pro Phe Leu Pro His Ser 
        115                 120                 125             


Ser Arg Cys Ala Gly Ser Gly Gly Gln Leu Asp Ser Ile Leu Pro His 
    130                 135                 140                 


Gln Ser Pro Ala Trp Gly Pro Trp Gly Cys Lys Asp Leu Ser Ser Gly 
145                 150                 155                 160 


Phe Pro Ser Phe Leu Xaa Ser Ser Ile Leu Trp Lys Ser Ala Val Val 
                165                 170                 175     


Lys 
    


<210> 3184
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<400> 3184
Met Gly Asn Ile Phe Glu Lys Leu Phe Lys Ser Leu Leu Gly Lys Lys 
1               5                   10                  15      


Lys Met Arg Ile Leu Ile Leu Ser Leu Asp Xaa Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Xaa Val Pro Ala Val Pro Xaa 
        35                  40                  45              


Val Gly Phe Cys Val Glu Xaa Val Glu Tyr Lys Asn Asn Xaa Phe Ala 
    50                  55                  60                  


Val Trp Asp Val Gly Ser His Phe Lys Ile Arg Pro Leu Trp Gln His 
65                  70                  75                  80  


Phe Phe Gln Asn Xaa Lys Ala Ala His Ser Gln Ser Leu Xaa Ser 
                85                  90                  95  


<210> 3185
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 3185
Met Gly Asn Ile Phe Glu Lys Leu Phe Lys Ser Leu Leu Gly Lys Lys 
1               5                   10                  15      


Lys Met Arg Ile Leu Ile Leu Ser Leu Asp Xaa Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Xaa Val Pro Ala Val Pro Xaa 
        35                  40                  45              


Val Gly Phe Cys Val Glu Xaa Val Glu Tyr Lys Asn Asn Xaa Phe Ala 
    50                  55                  60                  


Val Trp Asp Val Gly Ser His Phe Lys Ile Arg Pro Leu Trp Gln His 
65                  70                  75                  80  


Phe Phe Gln Asn Xaa Lys Glu Leu Ser Ala Ser Gln Phe Ala Gln Phe 
                85                  90                  95      


Ile Lys Lys Leu Cys Gly Val Xaa Gly Xaa Asn Asp Glu Ala Ser Pro 
            100                 105                 110         


Gly Ser Leu Xaa Ser Tyr Pro Ser His Leu Leu Asp Arg 
        115                 120                 125 


<210> 3186
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<400> 3186
Met Gly Asn Ile Phe Glu Lys Leu Phe Lys Ser Leu Leu Gly Lys Lys 
1               5                   10                  15      


Lys Met Arg Ile Leu Ile Leu Ser Leu Asp Xaa Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Xaa Val Pro Ala Val Pro Xaa 
        35                  40                  45              


Val Gly Phe Cys Val Glu Xaa Val Glu Tyr Lys Asn Asn Xaa Phe Ala 
    50                  55                  60                  


Val Trp Asp Val Gly Ser His Phe Lys Ile Arg Pro Leu Trp Gln His 
65                  70                  75                  80  


Phe Phe Gln Asn Xaa Lys Gly Ala Arg Ser Pro Gly Ser Xaa His Gln 
                85                  90                  95      


Gly Ser Leu Ala Ser Gly Val Leu Pro Ile Lys Cys Ser His Val Glu 
            100                 105                 110         


Phe Gly Met Trp Lys Gly Gly Arg Ser His Pro Phe Leu Pro His Ser 
        115                 120                 125             


Ser Arg Cys Ala Gly Ser Gly Gly Gln Leu Asp Ser Ile Leu Pro His 
    130                 135                 140                 


Gln Ser Pro Ala Trp Gly Pro Trp Gly Cys Lys Asp Leu Ser Ser Gly 
145                 150                 155                 160 


Phe Pro Ser Phe Leu Xaa Ser Ser Ile Leu Trp Lys Ser Ala Val Leu 
                165                 170                 175     


Leu Xaa Pro Lys Ala 
            180     


<210> 3187
<211> 177
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 3187
Met Gly Asn Ile Phe Glu Lys Leu Phe Lys Ser Leu Leu Gly Lys Lys 
1               5                   10                  15      


Lys Met Arg Ile Leu Ile Leu Ser Leu Asp Xaa Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Xaa Val Pro Ala Val Pro Xaa 
        35                  40                  45              


Val Gly Phe Cys Val Glu Xaa Val Glu Tyr Lys Asn Asn Xaa Phe Ala 
    50                  55                  60                  


Val Trp Asp Val Gly Ser His Phe Lys Ile Arg Pro Leu Trp Gln His 
65                  70                  75                  80  


Phe Phe Gln Asn Xaa Lys Gly Ala Arg Ser Pro Gly Ser Xaa His Gln 
                85                  90                  95      


Gly Ser Leu Ala Ser Gly Val Leu Pro Ile Lys Cys Ser His Val Glu 
            100                 105                 110         


Phe Gly Met Trp Lys Gly Gly Arg Ser His Pro Phe Leu Pro His Ser 
        115                 120                 125             


Ser Arg Cys Ala Gly Ser Gly Gly Gln Leu Asp Ser Ile Leu Pro His 
    130                 135                 140                 


Gln Ser Pro Ala Trp Gly Pro Trp Gly Cys Lys Asp Leu Ser Ser Gly 
145                 150                 155                 160 


Phe Pro Ser Phe Leu Xaa Ser Ser Ile Leu Trp Lys Ser Ala Val Val 
                165                 170                 175     


Lys 
    


<210> 3188
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<400> 3188
Met Gly Asn Ile Phe Glu Lys Leu Phe Lys Ser Leu Leu Gly Lys Lys 
1               5                   10                  15      


Lys Met Arg Ile Leu Ile Leu Ser Leu Asp Xaa Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Xaa Val Pro Ala Val Pro Xaa 
        35                  40                  45              


Val Gly Phe Cys Val Glu Xaa Val Glu Tyr Lys Asn Asn Xaa Phe Ala 
    50                  55                  60                  


Val Trp Asp Val Gly Ser His Phe Lys Ile Arg Pro Leu Trp Gln His 
65                  70                  75                  80  


Phe Phe Gln Asn Xaa Lys Gly Ser 
                85              


<210> 3189
<211> 141
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 3189
Met Gly Asn Ile Phe Glu Lys Leu Phe Lys Ser Leu Leu Gly Lys Lys 
1               5                   10                  15      


Lys Met Arg Ile Leu Ile Leu Ser Leu Asp Xaa Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Xaa Val Pro Ala Val Pro Xaa 
        35                  40                  45              


Val Gly Phe Cys Val Glu Xaa Val Glu Tyr Lys Asn Asn Xaa Phe Ala 
    50                  55                  60                  


Val Trp Asp Val Gly Ser His Phe Lys Ile Arg Pro Leu Trp Gln His 
65                  70                  75                  80  


Phe Phe Gln Asn Xaa Lys Gly Ser Cys Ser Ile Asp Gln Ala Gly Val 
                85                  90                  95      


Gln Trp Arg Asp Leu Gly Ser Leu Gln Arg Pro Leu Pro Lys Leu Arg 
            100                 105                 110         


Phe Val Ser His Xaa Ser Pro His Xaa Lys Leu Leu His Xaa Arg Pro 
        115                 120                 125             


Arg Xaa Ala Ser Arg Lys Cys Phe Phe Arg Gly Lys Ile 
    130                 135                 140     


<210> 3190
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<400> 3190
Xaa Asp Val Gly Ser His Phe Lys Ile Arg Pro Leu Trp Gln His Phe 
1               5                   10                  15      


Phe Gln Asn Xaa Lys Gly Ala Arg Ser Pro Gly Ser Xaa His Gln Gly 
            20                  25                  30          


Ser Leu Ala Ser Gly Val Leu Pro Ile Lys Cys Ser His Val Glu Phe 
        35                  40                  45              


Gly Met Trp Lys Gly Gly Arg Ser His Pro Phe Leu Pro His Ser Ser 
    50                  55                  60                  


Arg Cys Ala Gly Ser Gly Gly Gln Leu Asp Ser Ile Leu Pro His Gln 
65                  70                  75                  80  


Ser Pro Ala Trp Gly Pro Trp Gly Cys Lys Asp Leu Ser Ser Gly Phe 
                85                  90                  95      


Pro Ser Phe Leu Xaa Ser Ser Ile Leu Trp Lys Ser Ala Val Gln 
            100                 105                 110     


<210> 3191
<211> 184
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<400> 3191
Met Gly Leu Leu Xaa Ile Leu Lys Lys Met Lys Gln Lys Glu Arg Glu 
1               5                   10                  15      


Leu Arg Leu Leu Met Leu Gly Leu Asp Asn Ala Gly Lys Xaa Xaa Ile 
            20                  25                  30          


Leu Lys Lys Phe Asn Gly Glu Asp Ile Asp Xaa Ile Ser Pro Xaa Leu 
        35                  40                  45              


Gly Phe Asn Ile Lys Xaa Leu Glu His Arg Gly Phe Lys Leu Asn Ile 
    50                  55                  60                  


Trp Asp Val Gly Gly Gln Lys Ser Leu Arg Ser Tyr Trp Arg Asn Tyr 
65                  70                  75                  80  


Phe Glu Ser Xaa Asp Gly Leu Ile Trp Val Val Asp Ser Ala Asp Arg 
                85                  90                  95      


Gln Arg Met Gln Asp Cys Gln Arg Glu Leu Gln Ser Leu Leu Val Glu 
            100                 105                 110         


Glu Arg Leu Ala Gly Ala Xaa Leu Leu Ile Phe Ala Asn Lys Gln Asp 
        115                 120                 125             


Leu Pro Gly Ala Leu Ser Ser Asn Ala Ile Arg Glu Val Leu Glu Leu 
    130                 135                 140                 


Asp Ser Ile Arg Ser His His Trp Cys Ile Gln Gly Cys Ser Ala Val 
145                 150                 155                 160 


Xaa Gly Glu Asn Leu Leu Pro Gly Ile Asp Trp Leu Leu Asp Asp Ile 
                165                 170                 175     


Ser Ser Arg Ile Phe Xaa Ala Asp 
            180                 


<210> 3192
<211> 157
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<400> 3192
Met Gly Leu Leu Xaa Ile Leu Lys Lys Met Lys Gln Lys Glu Arg Glu 
1               5                   10                  15      


Leu Arg Leu Leu Met Leu Gly Leu Asp Asn Ala Gly Lys Xaa Xaa Ile 
            20                  25                  30          


Leu Lys Lys Phe Asn Gly Glu Asp Ile Asp Xaa Ile Ser Pro Xaa Leu 
        35                  40                  45              


Gly Phe Asn Ile Lys Xaa Leu Glu His Arg Gly Phe Lys Leu Asn Ile 
    50                  55                  60                  


Trp Asp Val Gly Gly Gln Lys Ser Leu Arg Ser Tyr Trp Arg Asn Tyr 
65                  70                  75                  80  


Phe Glu Ser Xaa Asp Gly Leu Ile Trp Val Val Asp Ser Ala Asp Arg 
                85                  90                  95      


Gln Arg Met Gln Asp Cys Gln Arg Glu Leu Gln Ser Leu Leu Val Glu 
            100                 105                 110         


Glu Val Leu Glu Leu Asp Ser Ile Arg Ser His His Trp Cys Ile Gln 
        115                 120                 125             


Gly Cys Ser Ala Val Xaa Gly Glu Asn Leu Leu Pro Gly Ile Asp Trp 
    130                 135                 140                 


Leu Leu Asp Asp Ile Ser Ser Arg Ile Phe Xaa Ala Asp 
145                 150                 155         


<210> 3193
<211> 163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<400> 3193
Met Asp Ala Leu Glu Gly Glu Ser Phe Ala Leu Ser Phe Ser Ser Ala 
1               5                   10                  15      


Ser Asp Ala Glu Phe Asp Ala Val Val Gly Tyr Leu Glu Asp Ile Ile 
            20                  25                  30          


Met Asp Asp Glu Phe Gln Leu Leu Gln Arg Asn Phe Met Asp Lys Tyr 
        35                  40                  45              


Tyr Leu Glu Phe Glu Asp Xaa Glu Glu Asn Lys Leu Ile Tyr Xaa Pro 
    50                  55                  60                  


Ile Phe Asn Glu Tyr Ile Ser Leu Val Glu Lys Tyr Ile Glu Glu Gln 
65                  70                  75                  80  


Leu Leu Gln Arg Ile Pro Glu Phe Asn Met Ala Ala Phe Xaa Xaa Xaa 
                85                  90                  95      


Leu Gln His His Lys Asp Glu Val Ala Gly Asp Ile Phe Asp Met Leu 
            100                 105                 110         


Leu Xaa Phe Xaa Asp Phe Leu Ala Phe Lys Glu Met Phe Leu Asp Tyr 
        115                 120                 125             


Arg Ala Glu Lys Glu Gly Arg Gly Leu Asp Leu Ser Ser Gly Leu Val 
    130                 135                 140                 


Val Xaa Ser Leu Cys Lys Ser Ser Ser Leu Pro Ala Ser Gln Asn Asn 
145                 150                 155                 160 


Leu Arg His 
            


<210> 3194
<211> 123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<400> 3194
Met Asp Ala Leu Glu Gly Glu Ser Phe Ala Leu Ser Phe Ser Ser Ala 
1               5                   10                  15      


Ser Asp Ala Glu Phe Asp Ala Val Val Gly Tyr Leu Glu Asp Ile Ile 
            20                  25                  30          


Met Glu Lys Tyr Ile Glu Glu Gln Leu Leu Gln Arg Ile Pro Glu Phe 
        35                  40                  45              


Asn Met Ala Ala Phe Xaa Xaa Xaa Leu Gln His His Lys Asp Glu Val 
    50                  55                  60                  


Ala Gly Asp Ile Phe Asp Met Leu Leu Xaa Phe Xaa Asp Phe Leu Ala 
65                  70                  75                  80  


Phe Lys Glu Met Phe Leu Asp Tyr Arg Ala Glu Lys Glu Gly Arg Gly 
                85                  90                  95      


Leu Asp Leu Ser Ser Gly Leu Val Val Xaa Ser Leu Cys Lys Ser Ser 
            100                 105                 110         


Ser Leu Pro Ala Ser Gln Asn Asn Leu Arg His 
        115                 120             


<210> 3195
<211> 171
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<400> 3195
Xaa Leu Glu Gly Glu Ser Phe Ala Leu Ser Phe Ser Ser Ala Ser Asp 
1               5                   10                  15      


Ala Glu Phe Asp Ala Val Val Gly Tyr Leu Glu Asp Ile Ile Met Asp 
            20                  25                  30          


Asp Glu Phe Gln Leu Leu Gln Arg Asn Phe Met Asp Lys Tyr Tyr Leu 
        35                  40                  45              


Glu Phe Glu Asp Xaa Glu Glu Asn Lys Leu Ile Tyr Xaa Pro Ile Phe 
    50                  55                  60                  


Asn Glu Tyr Ile Ser Leu Val Glu Lys Tyr Ile Glu Glu Gln Leu Leu 
65                  70                  75                  80  


Gln Arg Ile Pro Glu Phe Asn Met Ala Ala Phe Xaa Xaa Xaa Leu Gln 
                85                  90                  95      


His His Lys Asp Glu Val Ala Gly Asp Ile Phe Asp Met Leu Leu Xaa 
            100                 105                 110         


Phe Xaa Asp Phe Leu Ala Phe Lys Glu Met Phe Leu Asp Tyr Arg Ala 
        115                 120                 125             


Leu Pro Arg Xaa Ile Cys Gly Xaa Arg Ser Tyr Leu Gln Pro Met Asn 
    130                 135                 140                 


Gly Ile Ile Leu Asp Val Xaa Ser Pro Ile Gly Ser Ala His Asp Asp 
145                 150                 155                 160 


Arg Xaa His Leu Gly Lys Xaa Asp Ser Val Met 
                165                 170     


<210> 3196
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<400> 3196
Met Gly Leu Leu Xaa Ile Leu Lys Lys Met Lys Gln Lys Glu Arg Glu 
1               5                   10                  15      


Leu Arg Leu Leu Met Leu Gly Leu Asp Asn Ala Gly Lys Xaa Xaa Ile 
            20                  25                  30          


Leu Lys Lys Phe Asn Gly Glu Asp Ile Asp Xaa Ile Ser Pro Xaa Leu 
        35                  40                  45              


Gly Phe Asn Ile Lys Xaa Leu Glu His Arg Gly Phe Lys Leu Asn Ile 
    50                  55                  60                  


Trp Asp Val Gly Gly Gln Lys Ser Leu Arg Ser Tyr Trp Arg Asn Tyr 
65                  70                  75                  80  


Phe Glu Ser Xaa Asp Gly Leu Ile Trp Val Val Asp Ser Ala Asp Arg 
                85                  90                  95      


Gln Arg Met Gln Asp Cys Gln Arg Glu Leu Gln Ser Leu Leu Val Glu 
            100                 105                 110         


Glu 
    


<210> 3197
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 3197
Met Gly Leu Leu Ser Ile Leu Arg Lys Leu Lys Ser Ala Pro Asp Gln 
1               5                   10                  15      


Glu Val Arg Ile Leu Leu Leu Gly Leu Asp Asn Ala Gly Lys Xaa Xaa 
            20                  25                  30          


Leu Leu Lys Gln Leu Ala Ser Glu Asp Ile Ser His Ile Xaa Pro Xaa 
        35                  40                  45              


Gln Gly Phe Asn Ile Lys Ser Val Gln Ser Gln Gly Phe Lys Leu Asn 
    50                  55                  60                  


Val Trp Asp Ile Gly Gly Gln Arg Lys Ile Arg Pro Tyr Trp Lys Asn 
65                  70                  75                  80  


Tyr Phe Glu Asn Xaa Asp Ile Leu Ile Tyr Val Ile Asp Ser Ala Asp 
                85                  90                  95      


Arg Lys Arg Phe Glu Glu Xaa Gly Gln Glu Leu Ala Glu Leu Leu Glu 
            100                 105                 110         


Glu Glu Lys Leu Ser Cys Val Pro Val Leu Ile Phe Ala Asn Lys Gln 
        115                 120                 125             


Asp Leu Leu Xaa Ala Ala Pro Ala Ser Glu Ile Ala Glu Gly Leu Asn 
    130                 135                 140                 


Leu His Xaa Ile Arg Asp Arg Val Trp Gln Ile Gln Ser Cys Ser Ala 
145                 150                 155                 160 


Leu Xaa Gly Glu Gly Val Gln Asp Gly Met Asn Trp Val Cys Lys Asn 
                165                 170                 175     


Val Asn Ala Lys Lys Lys 
            180         


<210> 3198
<211> 51
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<400> 3198
Met Gly Asn Gly Leu Ser Asp Gln Xaa Ser Ile Leu Ser Asn Leu Pro 
1               5                   10                  15      


Ser Phe Gln Ser Phe His Ile Val Ile Leu Gly Leu Asp Cys Ala Gly 
            20                  25                  30          


Lys Xaa Xaa Val Leu Tyr Arg Leu Gln Phe Asn Glu Phe Val Asn Xaa 
        35                  40                  45              


Val Pro Xaa 
    50      


<210> 3199
<211> 200
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<400> 3199
Met Gly Asn Gly Leu Ser Asp Gln Xaa Ser Ile Leu Ser Asn Leu Pro 
1               5                   10                  15      


Ser Phe Gln Ser Phe His Ile Val Ile Leu Gly Leu Asp Cys Ala Gly 
            20                  25                  30          


Lys Xaa Xaa Val Leu Tyr Arg Leu Gln Phe Asn Glu Phe Val Asn Xaa 
        35                  40                  45              


Val Pro Xaa Lys Gly Phe Asn Xaa Glu Lys Ile Lys Val Xaa Leu Gly 
    50                  55                  60                  


Asn Ser Lys Xaa Val Xaa Phe His Phe Trp Asp Val Gly Gly Gln Glu 
65                  70                  75                  80  


Lys Leu Arg Pro Leu Trp Lys Ser Tyr Xaa Arg Cys Xaa Asp Gly Ile 
                85                  90                  95      


Val Phe Val Val Asp Ser Val Asp Val Glu Arg Met Glu Glu Ala Lys 
            100                 105                 110         


Xaa Glu Leu His Lys Ile Xaa Arg Ile Ser Glu Asn Gln Gly Val Pro 
        115                 120                 125             


Val Leu Ile Val Ala Asn Lys Gln Asp Leu Arg Asn Ser Leu Ser Leu 
    130                 135                 140                 


Ser Glu Ile Glu Lys Leu Leu Ala Met Gly Glu Leu Ser Ser Ser Xaa 
145                 150                 155                 160 


Pro Trp His Leu Gln Pro Xaa Cys Ala Ile Ile Gly Asp Gly Leu Lys 
                165                 170                 175     


Glu Gly Leu Glu Lys Leu His Asp Met Ile Ile Lys Arg Arg Lys Met 
            180                 185                 190         


Leu Arg Gln Gln Lys Lys Lys Arg 
        195                 200 


<210> 3200
<211> 192
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 3200
Met Gly Asn Ile Ser Ser Asn Ile Ser Ala Phe Gln Ser Leu His Ile 
1               5                   10                  15      


Val Met Leu Gly Leu Asp Ser Ala Gly Lys Xaa Xaa Val Leu Tyr Arg 
            20                  25                  30          


Leu Lys Phe Asn Glu Phe Val Asn Xaa Val Pro Xaa Ile Gly Phe Asn 
        35                  40                  45              


Xaa Glu Lys Ile Lys Leu Ser Asn Gly Xaa Ala Lys Gly Ile Ser Cys 
    50                  55                  60                  


His Phe Trp Asp Val Gly Gly Gln Glu Lys Leu Arg Pro Leu Trp Lys 
65                  70                  75                  80  


Ser Tyr Ser Arg Cys Xaa Asp Gly Ile Ile Tyr Val Val Asp Ser Val 
                85                  90                  95      


Asp Val Asp Arg Leu Glu Glu Ala Lys Xaa Glu Leu His Lys Val Xaa 
            100                 105                 110         


Lys Phe Ala Glu Asn Gln Gly Xaa Pro Leu Leu Val Ile Ala Asn Lys 
        115                 120                 125             


Gln Asp Leu Pro Lys Ser Leu Pro Val Ala Glu Ile Glu Lys Gln Leu 
    130                 135                 140                 


Ala Leu His Glu Leu Ile Pro Ala Xaa Xaa Tyr His Val Gln Pro Ala 
145                 150                 155                 160 


Cys Ala Ile Ile Gly Glu Gly Leu Xaa Glu Gly Met Asp Lys Leu Tyr 
                165                 170                 175     


Glu Met Ile Leu Lys Arg Arg Lys Ser Leu Lys Gln Lys Lys Lys Arg 
            180                 185                 190         


<210> 3201
<211> 201
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<400> 3201
Met Gly Asn Ile Ser Ser Asn Ile Ser Ala Phe Gln Ser Leu His Ile 
1               5                   10                  15      


Val Met Leu Gly Leu Asp Ser Ala Gly Lys Xaa Xaa Val Leu Tyr Arg 
            20                  25                  30          


Leu Lys Phe Asn Glu Phe Val Asn Xaa Val Pro Xaa Ile Gly Phe Asn 
        35                  40                  45              


Xaa Glu Lys Ile Lys Leu Ser Asn Gly Xaa Ala Lys Gly Ile Ser Cys 
    50                  55                  60                  


His Phe Trp Asp Val Gly Gly Gln Glu Lys Leu Arg Pro Leu Trp Lys 
65                  70                  75                  80  


Ser Tyr Ser Arg Cys Xaa Asp Gly Ile Ile Tyr Val Val Asp Ser Val 
                85                  90                  95      


Asp Val Asp Arg Leu Glu Glu Ala Lys Xaa Glu Leu His Lys Val Xaa 
            100                 105                 110         


Lys Phe Ala Glu Asn Gln Gly Xaa Pro Leu Leu Val Ile Ala Asn Lys 
        115                 120                 125             


Gln Asp Leu Pro Lys Ser Leu Pro Val Ala Glu Ile Glu Lys Gln Leu 
    130                 135                 140                 


Ala Leu His Glu Leu Ile Pro Ala Xaa Xaa Tyr His Val Gln Pro Ala 
145                 150                 155                 160 


Cys Ala Ile Ile Gly Glu Gly Leu Xaa Glu Gly Met Asp Lys Leu Tyr 
                165                 170                 175     


Glu Met Ile Leu Lys Arg Arg Lys Ser Leu Lys Gln Lys Lys Lys Arg 
            180                 185                 190         


Xaa Gly Asp Leu Arg Ser Cys Glu Val 
        195                 200     


<210> 3202
<211> 201
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<400> 3202
Met Gly Asn His Leu Xaa Glu Met Ala Pro Xaa Ala Ser Ser Phe Leu 
1               5                   10                  15      


Pro His Phe Gln Ala Leu His Val Val Val Ile Gly Leu Asp Ser Ala 
            20                  25                  30          


Gly Lys Xaa Ser Leu Leu Tyr Arg Leu Lys Phe Lys Glu Phe Val Gln 
        35                  40                  45              


Ser Val Pro Xaa Lys Gly Phe Asn Xaa Glu Lys Ile Arg Val Pro Leu 
    50                  55                  60                  


Gly Gly Ser Arg Gly Ile Xaa Phe Gln Val Trp Asp Val Gly Gly Gln 
65                  70                  75                  80  


Glu Lys Leu Arg Pro Leu Trp Arg Ser Tyr Xaa Arg Arg Xaa Asp Gly 
                85                  90                  95      


Leu Val Phe Val Val Asp Ala Ala Glu Ala Glu Arg Leu Glu Glu Ala 
            100                 105                 110         


Lys Val Glu Leu His Arg Ile Ser Arg Ala Ser Asp Asn Gln Gly Val 
        115                 120                 125             


Pro Val Leu Val Leu Ala Asn Lys Gln Asp Gln Pro Gly Ala Leu Ser 
    130                 135                 140                 


Ala Ala Glu Val Glu Lys Arg Leu Ala Val Arg Glu Leu Ala Ala Ala 
145                 150                 155                 160 


Xaa Leu Xaa His Val Gln Gly Cys Ser Ala Val Asp Gly Leu Gly Leu 
                165                 170                 175     


Gln Gln Gly Leu Glu Arg Leu Tyr Glu Met Ile Leu Lys Arg Lys Lys 
            180                 185                 190         


Ala Ala Arg Gly Gly Lys Lys Arg Arg 
        195                 200     


<210> 3203
<211> 179
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<400> 3203
Met Gly Ile Leu Phe Xaa Arg Ile Trp Arg Leu Phe Asn His Gln Glu 
1               5                   10                  15      


His Lys Val Ile Ile Val Gly Leu Asp Asn Ala Gly Lys Xaa Xaa Ile 
            20                  25                  30          


Leu Tyr Gln Phe Ser Met Asn Glu Val Val His Xaa Ser Pro Xaa Ile 
        35                  40                  45              


Gly Ser Asn Val Glu Glu Ile Val Ile Asn Asn Xaa Arg Phe Leu Met 
    50                  55                  60                  


Trp Asp Ile Gly Gly Gln Glu Ser Leu Arg Ser Ser Trp Asn Xaa Tyr 
65                  70                  75                  80  


Tyr Xaa Asn Xaa Glu Phe Val Ile Val Val Val Asp Ser Xaa Asp Arg 
                85                  90                  95      


Glu Arg Ile Ser Val Xaa Arg Glu Glu Leu Tyr Lys Met Leu Ala His 
            100                 105                 110         


Glu Asp Leu Arg Lys Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp 
        115                 120                 125             


Val Lys Glu Cys Met Xaa Val Ala Glu Ile Ser Gln Phe Leu Lys Leu 
    130                 135                 140                 


Xaa Ser Ile Lys Asp His Gln Trp His Ile Gln Ala Cys Cys Ala Leu 
145                 150                 155                 160 


Xaa Gly Glu Gly Leu Cys Gln Gly Leu Glu Trp Met Met Ser Arg Leu 
                165                 170                 175     


Lys Ile Arg 
            


<210> 3204
<211> 142
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<400> 3204
Met Asn Glu Val Val His Xaa Ser Pro Xaa Ile Gly Ser Asn Val Glu 
1               5                   10                  15      


Glu Ile Val Ile Asn Asn Xaa Arg Phe Leu Met Trp Asp Ile Gly Gly 
            20                  25                  30          


Gln Glu Ser Leu Arg Ser Ser Trp Asn Xaa Tyr Tyr Xaa Asn Xaa Glu 
        35                  40                  45              


Phe Val Ile Val Val Val Asp Ser Xaa Asp Arg Glu Arg Ile Ser Val 
    50                  55                  60                  


Xaa Arg Glu Glu Leu Tyr Lys Met Leu Ala His Glu Asp Leu Arg Lys 
65                  70                  75                  80  


Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp Val Lys Glu Cys Met 
                85                  90                  95      


Xaa Val Ala Glu Ile Ser Gln Phe Leu Lys Leu Xaa Ser Ile Lys Asp 
            100                 105                 110         


His Gln Trp His Ile Gln Ala Cys Cys Ala Leu Xaa Gly Glu Gly Leu 
        115                 120                 125             


Cys Gln Gly Leu Glu Trp Met Met Ser Arg Leu Lys Ile Arg 
    130                 135                 140         


<210> 3205
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<400> 3205
Met Asn Glu Val Val His Xaa Ser Pro Xaa Ile Gly Ser Asn Val Glu 
1               5                   10                  15      


Glu Ile Val Ile Asn Asn Xaa Arg Phe Leu Met Trp Asp Ile Gly Gly 
            20                  25                  30          


Gln Glu Ser Leu Arg Ser Ser Trp Asn Xaa Tyr Tyr Xaa Asn Xaa Glu 
        35                  40                  45              


Phe Val Ile Val Val Val Asp Ser Xaa Asp Arg Glu Arg Ile Ser Val 
    50                  55                  60                  


Xaa Arg Glu Glu Leu Tyr Lys Met Leu Ala His Glu Lys 
65                  70                  75          


<210> 3206
<211> 179
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 3206
Met Gly Leu Ile Phe Ala Lys Leu Trp Ser Leu Phe Cys Asn Gln Glu 
1               5                   10                  15      


His Lys Val Ile Ile Val Gly Leu Asp Asn Ala Gly Lys Xaa Xaa Ile 
            20                  25                  30          


Leu Tyr Gln Phe Leu Met Asn Glu Val Val His Xaa Ser Pro Xaa Ile 
        35                  40                  45              


Gly Ser Asn Val Glu Glu Ile Val Val Lys Asn Xaa His Phe Leu Met 
    50                  55                  60                  


Trp Asp Ile Gly Gly Gln Glu Ser Leu Arg Ser Ser Trp Asn Xaa Tyr 
65                  70                  75                  80  


Tyr Ser Asn Xaa Glu Phe Ile Ile Leu Val Val Asp Ser Ile Asp Arg 
                85                  90                  95      


Glu Arg Leu Ala Ile Xaa Lys Glu Glu Leu Tyr Arg Met Leu Ala His 
            100                 105                 110         


Glu Asp Leu Arg Lys Ala Ala Val Leu Ile Phe Ala Asn Lys Gln Asp 
        115                 120                 125             


Met Lys Gly Cys Met Xaa Ala Ala Glu Ile Ser Lys Tyr Leu Xaa Leu 
    130                 135                 140                 


Ser Ser Ile Lys Asp His Pro Trp His Ile Gln Ser Cys Cys Ala Leu 
145                 150                 155                 160 


Xaa Gly Glu Gly Leu Cys Gln Gly Leu Glu Trp Met Xaa Ser Arg Ile 
                165                 170                 175     


Gly Val Arg 
            


<210> 3207
<211> 179
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<400> 3207
Met Gly Gln Leu Ile Ala Lys Leu Met Ser Ile Phe Gly Asn Gln Glu 
1               5                   10                  15      


His Xaa Val Ile Ile Val Gly Leu Asp Asn Glu Gly Lys Xaa Xaa Ile 
            20                  25                  30          


Leu Tyr Arg Phe Leu Xaa Asn Glu Val Val His Met Cys Pro Xaa Ile 
        35                  40                  45              


Gly Ser Asn Val Glu Glu Ile Ile Leu Pro Lys Xaa His Phe Phe Met 
    50                  55                  60                  


Trp Asp Ile Val Arg Pro Glu Ala Leu Ser Phe Ile Trp Asn Xaa Tyr 
65                  70                  75                  80  


Tyr Ser Asn Xaa Glu Phe Ile Ile Leu Val Ile Asp Ser Xaa Asp Arg 
                85                  90                  95      


Asp Arg Leu Leu Xaa Xaa Arg Glu Glu Leu Tyr Lys Met Leu Ala His 
            100                 105                 110         


Glu Ala Leu Gln Asp Ala Ser Val Leu Ile Phe Ala Asn Lys Gln Asp 
        115                 120                 125             


Val Lys Asp Ser Met Arg Met Val Glu Ile Ser His Phe Leu Xaa Leu 
    130                 135                 140                 


Ser Xaa Ile Lys Asp His Ser Trp His Ile Gln Gly Cys Cys Ala Leu 
145                 150                 155                 160 


Xaa Arg Glu Gly Leu Pro Ala Arg Leu Gln Trp Met Glu Ser Gln Ala 
                165                 170                 175     


Ala Ala Asn 
            


<210> 3208
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<400> 3208
Asn Xaa Tyr Tyr Ser Asn Xaa Glu Phe Ile Ile Leu Val Ile Asp Ser 
1               5                   10                  15      


Xaa Asp Arg Asp Arg Leu Leu Xaa Xaa Arg Glu Glu Leu Tyr Lys Met 
            20                  25                  30          


Leu Ala His Glu Ala Leu Gln Asp Ala Ser Val Leu Ile Phe Ala Asn 
        35                  40                  45              


Lys Gln Asp Val Lys Asp Ser Met Arg Met Val Glu Ile Ser His Phe 
    50                  55                  60                  


Leu Xaa Leu Ser Xaa Ile Lys Asp His Ser Trp His Ile Gln Gly Cys 
65                  70                  75                  80  


Cys Ala Leu Xaa Arg Glu Gly Leu Val Ala Ala Leu Pro Gly Ser Leu 
                85                  90                  95      


Gly Pro Gly 
            


<210> 3209
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<400> 3209
Ile Leu Pro Xaa Ile Gly Phe Ser Ile Glu Lys Phe Lys Ser Ser Ser 
1               5                   10                  15      


Leu Ser Phe Xaa Val Phe Asp Met Ser Gly Gln Gly Arg Tyr Arg Asn 
            20                  25                  30          


Leu Trp Glu His Tyr Tyr Lys Glu Gly Gln Ala Ile Ile Phe Val Ile 
        35                  40                  45              


Asp Ser Ser Asp Arg Leu Arg Met Val Val Ala Lys Glu Glu Leu Asp 
    50                  55                  60                  


Xaa Leu Leu Asn His Pro Asp Ile Lys His Arg Arg Ile Pro Ile Leu 
65                  70                  75                  80  


Phe Phe Ala Asn Lys Met Asp Leu Arg Asp Ala Val Xaa Ser Val Lys 
                85                  90                  95      


Val Ser Gln Leu Leu Cys Leu Glu Asn Ile Lys Asp Lys Pro Trp His 
            100                 105                 110         


Ile Cys Ala Ser Asp Ala Ile Lys Gly Glu Gly Leu Gln Glu Gly Val 
        115                 120                 125             


Asp Trp Leu Gln Glu Lys Xaa Ile Gln Ser Asp Pro Asp Cys Glu Asp 
    130                 135                 140                 


Met Lys Arg 
145         


<210> 3210
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 3210
Met Gly Leu Leu Asp Arg Leu Ser Val Leu Leu Gly Leu Lys Lys Lys 
1               5                   10                  15      


Glu Val His Val Leu Cys Leu Gly Leu Asp Asn Ser Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Ile Asn Lys Leu Lys Pro Ser Asn Ala Gln Ser Gln Asn Ile Leu 
        35                  40                  45              


Pro Xaa Ile Gly Phe Ser Ile Glu Lys Phe Lys Ser Ser Ser Leu Ser 
    50                  55                  60                  


Phe Xaa Val Phe Asp Met Ser Gly Gln Gly Arg Tyr Arg Asn Leu Trp 
65                  70                  75                  80  


Glu His Tyr Tyr Lys Glu Gly Gln Ala Ile Ile Phe Val Ile Asp Ser 
                85                  90                  95      


Ser Asp Arg Leu Arg Met Val Val Ala Lys Glu Glu Leu Asp Xaa Leu 
            100                 105                 110         


Leu Asn His Pro Asp Ile Lys His Arg 
        115                 120     


<210> 3211
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<400> 3211
Met Gly Leu Leu Asp Arg Leu Ser Val Leu Leu Gly Leu Lys Lys Lys 
1               5                   10                  15      


Glu Val His Val Leu Cys Leu Gly Leu Asp Asn Ser Gly Lys Xaa Xaa 
            20                  25                  30          


Ile Ile Asn Lys Leu Lys Pro Ser Asn Ala Gln Ser Gln Asn Ile Leu 
        35                  40                  45              


Pro Xaa Ile Gly Phe Ser Ile Glu Lys Phe Lys Ser Ser Ser Leu Ser 
    50                  55                  60                  


Phe Xaa Val Phe Asp Met Ser Gly Gln Gly Arg Tyr Arg Asn Leu Trp 
65                  70                  75                  80  


Glu His Tyr Tyr Lys Glu Gly Gln Ala Ile Ile Phe Val Ile Asp Ser 
                85                  90                  95      


Ser Asp Arg Leu Arg Met Val Val Ala Lys Glu Glu Leu Asp Xaa Leu 
            100                 105                 110         


Leu Asn His Pro Asp Ile Lys His Arg Arg Ile Pro Ile Leu Phe Phe 
        115                 120                 125             


Ala Asn Lys Met Asp Leu Arg Asp Ala Val Xaa Ser Val Lys Val Ser 
    130                 135                 140                 


Gln Leu Leu Cys Leu Glu Asn Ile Lys Asp Lys Pro Trp His Ile Cys 
145                 150                 155                 160 


Ala Ser Asp Ala Ile Lys Gly Glu Gly Leu Gln Glu Gly Val Asp Trp 
                165                 170                 175     


Leu Gln Asp Gln Ile Gln Xaa Val Lys Xaa 
            180                 185     


<210> 3212
<211> 54
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<400> 3212
Xaa Glu Glu Leu Asp Xaa Leu Leu Asn His Pro Asp Ile Lys His Arg 
1               5                   10                  15      


Arg Ile Pro Ile Leu Phe Phe Ala Asn Lys Met Asp Leu Arg Asp Ala 
            20                  25                  30          


Val Xaa Ser Val Lys Val Ser Gln Leu Leu Cys Leu Glu Asn Ile Lys 
        35                  40                  45              


Asp Lys Pro Trp His Ile 
    50                  


<210> 3213
<211> 59
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<400> 3213
Met Asp Val Asn Ile Ala Pro Leu Arg Ala Trp Asp Asp Phe Phe Pro 
1               5                   10                  15      


Gly Ser Asp Arg Phe Ala Arg Pro Asp Phe Arg Asp Ile Ser Lys Trp 
            20                  25                  30          


Asn Asn Arg Val Val Ser Asn Leu Leu Tyr Tyr Gln Xaa Asn Tyr Leu 
        35                  40                  45              


Val Val Ala Ala Met Met Ile Ser Ile Val Gly 
    50                  55                  


<210> 3214
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<400> 3214
Met Asp Val Asn Ile Ala Pro Leu Arg Ala Trp Asp Asp Phe Phe Pro 
1               5                   10                  15      


Gly Ser Asp Arg Phe Ala Arg Pro Asp Phe Arg Asp Ile Ser Lys Trp 
            20                  25                  30          


Asn Asn Arg Val Val Ser Asn Leu Leu Tyr Tyr Gln Xaa Asn Tyr Leu 
        35                  40                  45              


Val Val Ala Ala Met Met Ile Ser Ile Val Gly Phe Leu Ser Pro Phe 
    50                  55                  60                  


Asn Met Ile Leu Gly Gly Ile Val Val Val Leu Val Phe Xaa Gly Phe 
65                  70                  75                  80  


Val Trp Ala Ala His Asn Lys Asp Val Leu Arg Arg Met Lys Lys Arg 
                85                  90                  95      


Tyr Pro Xaa Xaa Phe Val Met Val Val Met Leu Ala Ser Tyr Phe Leu 
            100                 105                 110         


Ile Ser Met Phe Gly Gly Val Met Val Phe Val Phe Gly Ile Xaa Phe 
        115                 120                 125             


Pro Leu Leu Leu Met Phe Ile His Ala Ser Leu Arg Leu Arg Asn Leu 
    130                 135                 140                 


Lys Asn Lys Leu Glu Asn Lys Met Glu Gly Ile Gly Leu Lys Arg Xaa 
145                 150                 155                 160 


Pro Met Gly Ile Val Leu Asp Ala Leu Glu Gln Gln Glu Glu Gly Ile 
                165                 170                 175     


Asn Arg Leu Xaa Asp Tyr Ile Ser Lys Val Lys Glu 
            180                 185             


<210> 3215
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<400> 3215
Met Asp Val Asn Ile Ala Pro Leu Arg Ala Trp Asp Asp Phe Phe Pro 
1               5                   10                  15      


Gly Ser Asp Arg Phe Ala Arg Pro Asp Phe Arg Asp Ile Ser Lys Trp 
            20                  25                  30          


Asn Asn Arg Val Val Ser Asn Leu Leu Tyr Tyr Gln Xaa Asn Tyr Leu 
        35                  40                  45              


Val Val Ala Ala Met Met Ile Ser Ile Val Gly Phe Leu Ser Pro Phe 
    50                  55                  60                  


Asn Pro Pro Ile Val Ser Glu Val Ser Arg Val Phe Met Lys Ser Asn 
65                  70                  75                  80  


Gly Lys Trp Ile Xaa Arg Phe Leu 
                85              


<210> 3216
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<400> 3216
Met Asp Val Asn Ile Ala Pro Leu Arg Ala Trp Asp Asp Phe Phe Pro 
1               5                   10                  15      


Gly Ser Asp Arg Phe Ala Arg Pro Asp Phe Arg Asp Ile Ser Lys Trp 
            20                  25                  30          


Asn Asn Arg Val Val Ser Asn Leu Leu Tyr Tyr Gln Xaa Asn Tyr Leu 
        35                  40                  45              


Val Val Ala Ala Met Met Ile Ser Ile Val Gly Leu Glu Cys Asn Gly 
    50                  55                  60                  


Val Ile Ser Ala His Cys Asn Leu His Leu Leu Ser Ser Ser Asp Ser 
65                  70                  75                  80  


Pro Ala Ser Ala Ser Gln Val Ala Gly Ile Xaa Gly Phe 
                85                  90              


<210> 3217
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 3217
Met Ile Ala Leu Phe Asn Lys Leu Leu Asp Trp Phe Lys Ala Leu Phe 
1               5                   10                  15      


Trp Lys Glu Glu Met Glu Leu Xaa Leu Val Gly Leu Gln Tyr Ser Gly 
            20                  25                  30          


Lys Xaa Xaa Phe Val Asn Val Ile Ala Ser Gly Gln Phe Asn Glu Asp 
        35                  40                  45              


Met Ile Pro Xaa Val Gly Phe Asn Met Arg Lys Ile Xaa Lys Gly Asn 
    50                  55                  60                  


Val Xaa Ile Lys Leu Trp Asp Ile Gly Gly Gln Pro Arg Phe Arg Ser 
65                  70                  75                  80  


Met Trp Glu Arg Tyr Cys Arg Gly Val Ser Ala Ile Val Tyr Met Val 
                85                  90                  95      


Asp Ala Ala Asp Gln Glu Lys Ile Glu Ala Ser Lys Asn Glu Leu His 
            100                 105                 110         


Asn Leu Leu Asp Lys Pro Gln Leu Gln Gly Ile Pro Glu Ser Val Cys 
        115                 120                 125             


His Pro Gly Pro Arg Asp Leu Leu Leu Leu His Leu Leu Gln Arg Lys 
    130                 135                 140                 


Gly Gln His 
145         


<210> 3218
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 3218
Met Ile Ala Leu Phe Asn Lys Leu Leu Asp Trp Phe Lys Ala Leu Phe 
1               5                   10                  15      


Trp Lys Glu Glu Met Glu Leu Xaa Leu Val Gly Leu Gln Tyr Ser Gly 
            20                  25                  30          


Lys Xaa Xaa Phe Val Asn Val Ile Ala Ser Gly Gln Phe Asn Glu Asp 
        35                  40                  45              


Met Ile Pro Xaa Val Gly Phe Asn Met Arg Lys Ile Xaa Lys Gly Asn 
    50                  55                  60                  


Val Xaa Ile Lys Leu Trp Asp Ile Gly Gly Gln Pro Arg Phe Arg Ser 
65                  70                  75                  80  


Met Trp Glu Arg Tyr Cys Arg Gly Val Ser Ala Ile Val Tyr Met Val 
                85                  90                  95      


Asp Ala Ala Asp Gln Glu Lys Ile Glu Ala Ser Lys Asn Glu Leu His 
            100                 105                 110         


Asn Leu Leu Asp Lys Pro Gln Leu Gln Gly Ile Pro Val Leu Val Leu 
        115                 120                 125             


Gly Asn Lys Arg Asp Leu Pro Gly Ala Leu Asp Glu Lys Glu Leu Ile 
    130                 135                 140                 


Glu Lys Met Asn Leu Ser Ala Ile Gln Asp Arg Glu Ile Cys Cys Tyr 
145                 150                 155                 160 


Ser Ile Ser Cys Lys Glu Lys Asp Asn Ile Asp Ile Xaa Leu Gln Trp 
                165                 170                 175     


Leu Ile Gln His Ser Lys Ser Arg Arg Ser 
            180                 185     


<210> 3219
<211> 102
<212> PRT
<213> Homo sapiens

<400> 3219
Met Ile Arg Ser Ala Ser Trp Val Trp Leu Leu Pro Pro Ala Gly Val 
1               5                   10                  15      


Arg Pro Cys Arg Ala Gly Ala Pro Arg Ser Arg Trp Arg Val Arg Ala 
            20                  25                  30          


Glu Ala Arg Ser Cys Gly Ser Arg Arg Arg Arg Arg Ser Ser Val Leu 
        35                  40                  45              


Pro Ser Val Leu Ala Pro Gly Arg His His Ala Gly Ala His Leu Pro 
    50                  55                  60                  


Pro Ala Gly Leu Val Pro Phe Ala Leu Leu Glu Gly Arg Asp Gly Ala 
65                  70                  75                  80  


Asp Ala Arg Gly Ala Ala Val Leu Gly Gln Asp His Leu Arg Gln Cys 
                85                  90                  95      


His Arg Asp Gln Glu Ser 
            100         


<210> 3220
<211> 103
<212> PRT
<213> Homo sapiens

<400> 3220
Met Ile Arg Ser Ala Ser Trp Val Trp Leu Leu Pro Pro Ala Gly Val 
1               5                   10                  15      


Arg Pro Cys Arg Ala Gly Ala Pro Arg Ser Arg Trp Arg Val Arg Ala 
            20                  25                  30          


Glu Ala Arg Ser Cys Gly Ser Arg Arg Arg Arg Arg Ser Ser Val Leu 
        35                  40                  45              


Pro Ser Val Leu Ala Pro Gly Arg His His Ala Gly Ala His Leu Pro 
    50                  55                  60                  


Pro Ala Gly Leu Val Pro Phe Ala Leu Leu Glu Gly Arg Asp Gly Ala 
65                  70                  75                  80  


Asp Ala Arg Gly Ala Ala Val Leu Gly Gln Asp His Leu Arg Gln Cys 
                85                  90                  95      


His Arg Val Arg Ser Ile Gln 
            100             


<210> 3221
<211> 163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 3221
Met Leu Ala Leu Ile Ser Arg Leu Leu Asp Trp Phe Arg Ser Leu Phe 
1               5                   10                  15      


Trp Lys Glu Glu Met Glu Leu Xaa Leu Val Gly Leu Gln Tyr Ser Gly 
            20                  25                  30          


Lys Xaa Xaa Phe Val Asn Val Ile Ala Ser Gly Gln Phe Ser Glu Asp 
        35                  40                  45              


Met Ile Pro Xaa Val Gly Phe Asn Met Arg Lys Val Xaa Lys Gly Asn 
    50                  55                  60                  


Val Xaa Ile Lys Ile Trp Asp Ile Gly Gly Gln Pro Arg Phe Arg Ser 
65                  70                  75                  80  


Met Trp Glu Arg Tyr Cys Arg Gly Val Asn Ala Ile Val Tyr Met Ile 
                85                  90                  95      


Asp Ala Ala Asp Arg Glu Lys Ile Glu Ala Ser Arg Asn Glu Leu His 
            100                 105                 110         


Asn Leu Leu Asp Lys Pro Gln Leu Gln Gly Ile Pro Ile Ser His Phe 
        115                 120                 125             


Ser Gly Leu Phe Ser Ile Gln Asn Leu Glu Glu Ala Glu Ala Ser Pro 
    130                 135                 140                 


Glu Val Phe Gln Ser Phe Leu Ala Ile Ile Leu Glu Leu Leu Ser Val 
145                 150                 155                 160 


Pro Leu Lys 
            


<210> 3222
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 3222
Met Leu Ala Leu Ile Ser Arg Leu Leu Asp Trp Phe Arg Ser Leu Phe 
1               5                   10                  15      


Trp Lys Glu Glu Met Glu Leu Xaa Leu Val Gly Leu Gln Tyr Ser Gly 
            20                  25                  30          


Lys Xaa Xaa Phe Val Asn Val Ile Ala Ser Gly Gln Phe Ser Glu Asp 
        35                  40                  45              


Met Ile Pro Xaa Val Gly Phe Asn Met Arg Lys Val Xaa Lys Gly Asn 
    50                  55                  60                  


Val Xaa Ile Lys Ile Trp Asp Ile Gly Gly Gln Pro Arg Phe Arg Ser 
65                  70                  75                  80  


Met Trp Glu Arg Tyr Cys Arg Gly Val Asn Ala Ile Val Tyr Met Ile 
                85                  90                  95      


Asp Ala Ala Asp Arg Glu Lys Ile Glu Ala Ser Arg Asn Glu Leu His 
            100                 105                 110         


Asn Leu Leu Asp Lys Pro Gln Leu Gln Gly Ile Pro Val Leu Val Leu 
        115                 120                 125             


Gly Asn Lys Arg Asp Leu Pro Asn Ala Leu Asp Glu Lys Gln Leu Ile 
    130                 135                 140                 


Glu Lys Met Asn Leu Ser Ala Ile Gln Asp Arg Glu Ile Cys Cys Tyr 
145                 150                 155                 160 


Ser Ile Ser Cys Lys Glu Lys Asp Asn Ile Asp Ile Xaa Leu Gln Trp 
                165                 170                 175     


Leu Ile Gln His Ser Lys Ser Arg Arg Ser 
            180                 185     


<210> 3223
<211> 123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<400> 3223
Met Glu Phe Leu Glu Ile Gly Gly Ser Lys Pro Phe Arg Ser Tyr Trp 
1               5                   10                  15      


Glu Met Tyr Leu Ser Lys Gly Leu Leu Leu Ile Phe Val Val Asp Ser 
            20                  25                  30          


Ala Asp His Ser Arg Leu Pro Glu Ala Lys Lys Tyr Leu His Gln Leu 
        35                  40                  45              


Ile Ala Ala Asn Pro Val Leu Pro Leu Val Val Phe Ala Asn Lys Gln 
    50                  55                  60                  


Asp Leu Glu Ala Ala Tyr His Ile Xaa Asp Ile His Glu Ala Leu Ala 
65                  70                  75                  80  


Leu Ser Glu Val Gly Asn Asp Arg Lys Met Phe Leu Phe Gly Xaa Tyr 
                85                  90                  95      


Leu Xaa Lys Asn Gly Ser Glu Ile Pro Ser Xaa Met Gln Asp Ala Lys 
            100                 105                 110         


Asp Leu Ile Ala Gln Leu Ala Ala Asp Val Gln 
        115                 120             


<210> 3224
<211> 774
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<400> 3224
Met Ala Ala Xaa Xaa Ala Asn Pro Glu Met Xaa Ser Asp Val Pro Ser 
1               5                   10                  15      


Leu Gly Pro Ala Ile Ala Ser Gly Asn Ser Gly Pro Gly Ile Gln Gly 
            20                  25                  30          


Gly Gly Ala Ile Val Gln Arg Ala Ile Lys Arg Arg Pro Gly Leu Asp 
        35                  40                  45              


Phe Asp Asp Asp Gly Glu Gly Asn Ser Lys Phe Leu Arg Cys Asp Asp 
    50                  55                  60                  


Asp Gln Met Ser Asn Asp Lys Glu Arg Phe Ala Arg Glu Asn His Ser 
65                  70                  75                  80  


Glu Ile Glu Arg Arg Arg Arg Asn Lys Met Xaa Ala Tyr Ile Xaa Glu 
                85                  90                  95      


Leu Ser Asp Met Val Pro Xaa Cys Ser Ala Leu Ala Arg Lys Pro Asp 
            100                 105                 110         


Lys Leu Xaa Ile Leu Arg Met Ala Val Ser His Met Lys Ser Leu Arg 
        115                 120                 125             


Gly Xaa Gly Asn Xaa Ser Xaa Asp Gly Ser Tyr Lys Pro Ser Phe Leu 
    130                 135                 140                 


Xaa Asp Gln Glu Leu Lys His Leu Ile Leu Glu Ala Ala Asp Gly Phe 
145                 150                 155                 160 


Leu Phe Ile Val Ser Cys Glu Xaa Gly Arg Val Val Tyr Val Ser Asp 
                165                 170                 175     


Ser Val Xaa Pro Val Leu Asn Gln Pro Gln Ser Glu Trp Phe Gly Ser 
            180                 185                 190         


Xaa Leu Tyr Asp Gln Val His Pro Asp Asp Val Asp Lys Leu Arg Glu 
        195                 200                 205             


Gln Leu Ser Xaa Ser Glu Asn Ala Leu Xaa Gly Arg Ile Leu Asp Leu 
    210                 215                 220                 


Lys Xaa Gly Xaa Val Lys Lys Glu Gly Gln Gln Ser Ser Met Arg Met 
225                 230                 235                 240 


Cys Met Gly Ser Arg Arg Ser Phe Ile Cys Arg Met Arg Cys Gly Ser 
                245                 250                 255     


Ser Ser Val Asp Pro Val Ser Val Asn Arg Leu Ser Phe Val Arg Asn 
            260                 265                 270         


Arg Cys Arg Asn Gly Leu Gly Ser Val Lys Asp Gly Glu Pro His Phe 
        275                 280                 285             


Val Val Val His Cys Xaa Gly Tyr Ile Lys Ala Trp Pro Pro Ala Gly 
    290                 295                 300                 


Val Ser Leu Pro Asp Asp Asp Pro Glu Ala Gly Gln Gly Ser Lys Phe 
305                 310                 315                 320 


Cys Leu Val Ala Ile Gly Arg Leu Gln Val Xaa Ser Ser Pro Asn Cys 
                325                 330                 335     


Xaa Asp Met Ser Asn Val Cys Gln Pro Xaa Glu Phe Ile Ser Arg His 
            340                 345                 350         


Asn Ile Glu Gly Ile Phe Xaa Phe Val Asp His Arg Cys Val Ala Xaa 
        355                 360                 365             


Val Gly Tyr Gln Pro Gln Glu Leu Leu Gly Lys Asn Ile Val Glu Phe 
    370                 375                 380                 


Cys His Pro Glu Asp Gln Gln Leu Leu Arg Asp Ser Phe Gln Gln Val 
385                 390                 395                 400 


Val Lys Leu Lys Gly Gln Val Leu Ser Val Met Phe Arg Phe Arg Ser 
                405                 410                 415     


Lys Asn Gln Glu Trp Leu Trp Met Arg Xaa Ser Ser Phe Xaa Phe Gln 
            420                 425                 430         


Asn Pro Tyr Ser Asp Glu Ile Glu Tyr Ile Ile Cys Xaa Asn Xaa Asn 
        435                 440                 445             


Val Lys Asn Ser Ser Gln Glu Pro Arg Pro Xaa Leu Ser Asn Xaa Ile 
    450                 455                 460                 


Gln Arg Pro Gln Leu Gly Pro Xaa Ala Asn Leu Pro Leu Glu Met Gly 
465                 470                 475                 480 


Ser Gly Gln Leu Ala Pro Arg Gln Gln Gln Gln Gln Xaa Glu Leu Asp 
                485                 490                 495     


Met Val Pro Gly Arg Asp Gly Leu Ala Ser Tyr Asn His Ser Gln Val 
            500                 505                 510         


Val Gln Pro Val Xaa Xaa Xaa Gly Pro Glu His Ser Lys Pro Leu Glu 
        515                 520                 525             


Lys Ser Asp Gly Leu Phe Ala Gln Asp Arg Asp Pro Arg Phe Ser Glu 
    530                 535                 540                 


Ile Tyr His Asn Ile Asn Ala Asp Gln Ser Lys Gly Ile Ser Ser Ser 
545                 550                 555                 560 


Xaa Val Pro Ala Xaa Gln Gln Leu Phe Ser Gln Gly Asn Xaa Phe Pro 
                565                 570                 575     


Pro Xaa Pro Arg Pro Ala Glu Asn Phe Arg Asn Ser Gly Leu Ala Pro 
            580                 585                 590         


Pro Val Xaa Ile Val Gln Pro Ser Ala Ser Ala Gly Gln Met Leu Ala 
        595                 600                 605             


Gln Ile Ser Arg His Ser Asn Pro Xaa Gln Gly Ala Xaa Pro Xaa Trp 
    610                 615                 620                 


Xaa Pro Xaa Xaa Arg Ser Gly Phe Ser Ala Gln Gln Val Ala Xaa Gln 
625                 630                 635                 640 


Ala Xaa Ala Lys Xaa Arg Xaa Ser Gln Phe Gly Val Gly Ser Phe Gln 
                645                 650                 655     


Xaa Pro Ser Ser Phe Ser Ser Met Ser Leu Pro Gly Ala Pro Xaa Ala 
            660                 665                 670         


Ser Pro Gly Ala Ala Ala Tyr Pro Ser Leu Xaa Asn Arg Gly Ser Asn 
        675                 680                 685             


Phe Ala Pro Glu Xaa Gly Gln Xaa Ala Gly Gln Phe Gln Xaa Arg Xaa 
    690                 695                 700                 


Ala Glu Gly Val Gly Val Trp Pro Gln Trp Gln Gly Gln Gln Pro His 
705                 710                 715                 720 


His Arg Ser Ser Ser Ser Glu Gln His Val Gln Gln Pro Pro Ala Gln 
                725                 730                 735     


Gln Pro Gly Gln Pro Glu Val Phe Gln Glu Met Leu Ser Met Leu Gly 
            740                 745                 750         


Asp Gln Ser Asn Ser Tyr Asn Asn Glu Glu Phe Pro Asp Leu Xaa Met 
        755                 760                 765             


Phe Pro Pro Phe Ser Glu 
    770                 


<210> 3225
<211> 416
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<400> 3225
Met Ala Ala Xaa Xaa Ala Asn Pro Glu Met Xaa Ser Asp Val Pro Ser 
1               5                   10                  15      


Leu Gly Pro Ala Ile Ala Ser Gly Asn Ser Gly Pro Gly Ile Gln Gly 
            20                  25                  30          


Gly Gly Ala Ile Val Gln Arg Ala Ile Lys Arg Arg Pro Gly Leu Asp 
        35                  40                  45              


Phe Asp Asp Asp Gly Glu Gly Asn Ser Lys Phe Leu Arg Cys Asp Asp 
    50                  55                  60                  


Asp Gln Met Ser Asn Asp Lys Glu Arg Phe Ala Arg Ser Asp Asp Glu 
65                  70                  75                  80  


Gln Ser Ser Ala Asp Lys Glu Arg Leu Ala Arg Glu Asn His Ser Glu 
                85                  90                  95      


Ile Glu Arg Arg Arg Arg Asn Lys Met Xaa Ala Tyr Ile Xaa Glu Leu 
            100                 105                 110         


Ser Asp Met Val Pro Xaa Cys Ser Ala Leu Ala Arg Lys Pro Asp Lys 
        115                 120                 125             


Leu Xaa Ile Leu Arg Met Ala Val Ser His Met Lys Ser Leu Arg Gly 
    130                 135                 140                 


Xaa Gly Asn Xaa Ser Xaa Asp Gly Ser Tyr Lys Pro Ser Phe Leu Xaa 
145                 150                 155                 160 


Asp Gln Glu Leu Lys His Leu Ile Leu Glu Ala Ala Asp Gly Phe Leu 
                165                 170                 175     


Phe Ile Val Ser Cys Glu Xaa Gly Arg Val Val Tyr Val Ser Asp Ser 
            180                 185                 190         


Val Xaa Pro Val Leu Asn Gln Pro Gln Ser Glu Trp Phe Gly Ser Xaa 
        195                 200                 205             


Leu Tyr Asp Gln Val His Pro Asp Asp Val Asp Lys Leu Arg Glu Gln 
    210                 215                 220                 


Leu Ser Xaa Ser Glu Asn Ala Leu Xaa Gly Arg Ile Leu Asp Leu Lys 
225                 230                 235                 240 


Xaa Gly Xaa Val Lys Lys Glu Gly Gln Gln Ser Ser Met Arg Met Cys 
                245                 250                 255     


Met Gly Ser Arg Arg Ser Phe Ile Cys Arg Met Arg Cys Gly Ser Ser 
            260                 265                 270         


Ser Val Asp Pro Val Ser Val Asn Arg Leu Ser Phe Val Arg Asn Arg 
        275                 280                 285             


Cys Arg Asn Gly Leu Gly Ser Val Lys Asp Gly Glu Pro His Phe Val 
    290                 295                 300                 


Val Val His Cys Xaa Gly Tyr Ile Lys Ala Trp Pro Pro Ala Gly Val 
305                 310                 315                 320 


Ser Leu Pro Asp Asp Asp Pro Glu Ala Gly Gln Gly Ser Lys Phe Cys 
                325                 330                 335     


Leu Val Ala Ile Gly Arg Leu Gln Val Xaa Ser Ser Pro Asn Cys Xaa 
            340                 345                 350         


Asp Met Ser Asn Val Cys Gln Pro Xaa Glu Phe Ile Ser Arg His Asn 
        355                 360                 365             


Ile Glu Gly Ile Phe Xaa Phe Val Asp His Arg Cys Val Ala Xaa Val 
    370                 375                 380                 


Gly Tyr Gln Pro Gln Glu Leu Leu Gly Lys Asn Ile Val Glu Phe Cys 
385                 390                 395                 400 


His Pro Glu Asp Gln Gln Leu Leu Arg Asp Ser Phe Gln Gln Glu Leu 
                405                 410                 415     


<210> 3226
<211> 787
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<400> 3226
Met Ala Ala Xaa Xaa Ala Asn Pro Glu Met Xaa Ser Asp Val Pro Ser 
1               5                   10                  15      


Leu Gly Pro Ala Ile Ala Ser Gly Asn Ser Gly Pro Gly Ile Gln Gly 
            20                  25                  30          


Gly Gly Ala Ile Val Gln Arg Ala Ile Lys Arg Arg Pro Gly Leu Asp 
        35                  40                  45              


Phe Asp Asp Asp Gly Glu Gly Asn Ser Lys Phe Leu Arg Cys Asp Asp 
    50                  55                  60                  


Asp Gln Met Ser Asn Asp Lys Glu Arg Phe Ala Arg Ser Asp Asp Glu 
65                  70                  75                  80  


Gln Ser Ser Ala Asp Lys Glu Arg Leu Ala Arg Glu Asn His Ser Glu 
                85                  90                  95      


Ile Glu Arg Arg Arg Arg Asn Lys Met Xaa Ala Tyr Ile Xaa Glu Leu 
            100                 105                 110         


Ser Asp Met Val Pro Xaa Cys Ser Ala Leu Ala Arg Lys Pro Asp Lys 
        115                 120                 125             


Leu Xaa Ile Leu Arg Met Ala Val Ser His Met Lys Ser Leu Arg Gly 
    130                 135                 140                 


Xaa Gly Asn Xaa Ser Xaa Asp Gly Ser Tyr Lys Pro Ser Phe Leu Xaa 
145                 150                 155                 160 


Asp Gln Glu Leu Lys His Leu Ile Leu Glu Ala Ala Asp Gly Phe Leu 
                165                 170                 175     


Phe Ile Val Ser Cys Glu Xaa Gly Arg Val Val Tyr Val Ser Asp Ser 
            180                 185                 190         


Val Xaa Pro Val Leu Asn Gln Pro Gln Ser Glu Trp Phe Gly Ser Xaa 
        195                 200                 205             


Leu Tyr Asp Gln Val His Pro Asp Asp Val Asp Lys Leu Arg Glu Gln 
    210                 215                 220                 


Leu Ser Xaa Ser Glu Asn Ala Leu Xaa Gly Arg Ile Leu Asp Leu Lys 
225                 230                 235                 240 


Xaa Gly Xaa Val Lys Lys Glu Gly Gln Gln Ser Ser Met Arg Met Cys 
                245                 250                 255     


Met Gly Ser Arg Arg Ser Phe Ile Cys Arg Met Arg Cys Gly Ser Ser 
            260                 265                 270         


Ser Val Asp Pro Val Ser Val Asn Arg Leu Ser Phe Val Arg Asn Arg 
        275                 280                 285             


Cys Arg Asn Gly Leu Gly Ser Val Lys Asp Gly Glu Pro His Phe Val 
    290                 295                 300                 


Val Val His Cys Xaa Gly Tyr Ile Lys Ala Trp Pro Pro Ala Gly Val 
305                 310                 315                 320 


Ser Leu Pro Asp Asp Asp Pro Glu Ala Gly Gln Gly Ser Lys Phe Cys 
                325                 330                 335     


Leu Val Ala Ile Gly Arg Leu Gln Val Xaa Ser Ser Pro Asn Cys Xaa 
            340                 345                 350         


Asp Met Ser Asn Val Cys Gln Pro Xaa Glu Phe Ile Ser Arg His Asn 
        355                 360                 365             


Ile Glu Gly Ile Phe Xaa Phe Val Asp His Arg Cys Val Ala Xaa Val 
    370                 375                 380                 


Gly Tyr Gln Pro Gln Glu Leu Leu Gly Lys Asn Ile Val Glu Phe Cys 
385                 390                 395                 400 


His Pro Glu Asp Gln Gln Leu Leu Arg Asp Ser Phe Gln Gln Val Val 
                405                 410                 415     


Lys Leu Lys Gly Gln Val Leu Ser Val Met Phe Arg Phe Arg Ser Lys 
            420                 425                 430         


Asn Gln Glu Trp Leu Trp Met Arg Xaa Ser Ser Phe Xaa Phe Gln Asn 
        435                 440                 445             


Pro Tyr Ser Asp Glu Ile Glu Tyr Ile Ile Cys Xaa Asn Xaa Asn Val 
    450                 455                 460                 


Lys Asn Ser Ser Gln Glu Pro Arg Pro Xaa Leu Ser Asn Xaa Ile Gln 
465                 470                 475                 480 


Arg Pro Gln Leu Gly Pro Xaa Ala Asn Leu Pro Leu Glu Met Gly Ser 
                485                 490                 495     


Gly Gln Leu Ala Pro Arg Gln Gln Gln Gln Gln Xaa Glu Leu Asp Met 
            500                 505                 510         


Val Pro Gly Arg Asp Gly Leu Ala Ser Tyr Asn His Ser Gln Val Val 
        515                 520                 525             


Gln Pro Val Xaa Xaa Xaa Gly Pro Glu His Ser Lys Pro Leu Glu Lys 
    530                 535                 540                 


Ser Asp Gly Leu Phe Ala Gln Asp Arg Asp Pro Arg Phe Ser Glu Ile 
545                 550                 555                 560 


Tyr His Asn Ile Asn Ala Asp Gln Ser Lys Gly Ile Ser Ser Ser Xaa 
                565                 570                 575     


Val Pro Ala Xaa Gln Gln Leu Phe Ser Gln Gly Asn Xaa Phe Pro Pro 
            580                 585                 590         


Xaa Pro Arg Pro Ala Glu Asn Phe Ser Gly Leu Ala Pro Pro Val Xaa 
        595                 600                 605             


Ile Val Gln Pro Ser Ala Ser Ala Gly Gln Met Leu Ala Gln Ile Ser 
    610                 615                 620                 


Arg His Ser Asn Pro Xaa Gln Gly Ala Xaa Pro Xaa Trp Xaa Pro Xaa 
625                 630                 635                 640 


Xaa Arg Ser Gly Phe Ser Ala Gln Gln Val Ala Xaa Gln Ala Xaa Ala 
                645                 650                 655     


Lys Xaa Arg Xaa Ser Gln Phe Gly Val Gly Ser Phe Gln Xaa Pro Ser 
            660                 665                 670         


Ser Phe Ser Ser Met Ser Leu Pro Gly Ala Pro Xaa Ala Ser Pro Gly 
        675                 680                 685             


Ala Ala Ala Tyr Pro Ser Leu Xaa Asn Arg Gly Ser Asn Phe Ala Pro 
    690                 695                 700                 


Glu Xaa Gly Gln Xaa Ala Gly Gln Phe Gln Xaa Arg Xaa Ala Glu Gly 
705                 710                 715                 720 


Val Gly Val Trp Pro Gln Trp Gln Gly Gln Gln Pro His His Arg Ser 
                725                 730                 735     


Ser Ser Ser Glu Gln His Val Gln Gln Pro Pro Ala Gln Gln Pro Gly 
            740                 745                 750         


Gln Pro Glu Val Phe Gln Glu Met Leu Ser Met Leu Gly Asp Gln Ser 
        755                 760                 765             


Asn Ser Tyr Asn Asn Glu Glu Phe Pro Asp Leu Xaa Met Phe Pro Pro 
    770                 775                 780                 


Phe Ser Glu 
785         


<210> 3227
<211> 789
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<400> 3227
Met Ala Ala Xaa Xaa Ala Asn Pro Glu Met Xaa Ser Asp Val Pro Ser 
1               5                   10                  15      


Leu Gly Pro Ala Ile Ala Ser Gly Asn Ser Gly Pro Gly Ile Gln Gly 
            20                  25                  30          


Gly Gly Ala Ile Val Gln Arg Ala Ile Lys Arg Arg Pro Gly Leu Asp 
        35                  40                  45              


Phe Asp Asp Asp Gly Glu Gly Asn Ser Lys Phe Leu Arg Cys Asp Asp 
    50                  55                  60                  


Asp Gln Met Ser Asn Asp Lys Glu Arg Phe Ala Arg Ser Asp Asp Glu 
65                  70                  75                  80  


Gln Ser Ser Ala Asp Lys Glu Arg Leu Ala Arg Glu Asn His Ser Glu 
                85                  90                  95      


Ile Glu Arg Arg Arg Arg Asn Lys Met Xaa Ala Tyr Ile Xaa Glu Leu 
            100                 105                 110         


Ser Asp Met Val Pro Xaa Cys Ser Ala Leu Ala Arg Lys Pro Asp Lys 
        115                 120                 125             


Leu Xaa Ile Leu Arg Met Ala Val Ser His Met Lys Ser Leu Arg Gly 
    130                 135                 140                 


Xaa Gly Asn Xaa Ser Xaa Asp Gly Ser Tyr Lys Pro Ser Phe Leu Xaa 
145                 150                 155                 160 


Asp Gln Glu Leu Lys His Leu Ile Leu Glu Ala Ala Asp Gly Phe Leu 
                165                 170                 175     


Phe Ile Val Ser Cys Glu Xaa Gly Arg Val Val Tyr Val Ser Asp Ser 
            180                 185                 190         


Val Xaa Pro Val Leu Asn Gln Pro Gln Ser Glu Trp Phe Gly Ser Xaa 
        195                 200                 205             


Leu Tyr Asp Gln Val His Pro Asp Asp Val Asp Lys Leu Arg Glu Gln 
    210                 215                 220                 


Leu Ser Xaa Ser Glu Asn Ala Leu Xaa Gly Arg Ile Leu Asp Leu Lys 
225                 230                 235                 240 


Xaa Gly Xaa Val Lys Lys Glu Gly Gln Gln Ser Ser Met Arg Met Cys 
                245                 250                 255     


Met Gly Ser Arg Arg Ser Phe Ile Cys Arg Met Arg Cys Gly Ser Ser 
            260                 265                 270         


Ser Val Asp Pro Val Ser Val Asn Arg Leu Ser Phe Val Arg Asn Arg 
        275                 280                 285             


Cys Arg Asn Gly Leu Gly Ser Val Lys Asp Gly Glu Pro His Phe Val 
    290                 295                 300                 


Val Val His Cys Xaa Gly Tyr Ile Lys Ala Trp Pro Pro Ala Gly Val 
305                 310                 315                 320 


Ser Leu Pro Asp Asp Asp Pro Glu Ala Gly Gln Gly Ser Lys Phe Cys 
                325                 330                 335     


Leu Val Ala Ile Gly Arg Leu Gln Val Xaa Ser Ser Pro Asn Cys Xaa 
            340                 345                 350         


Asp Met Ser Asn Val Cys Gln Pro Xaa Glu Phe Ile Ser Arg His Asn 
        355                 360                 365             


Ile Glu Gly Ile Phe Xaa Phe Val Asp His Arg Cys Val Ala Xaa Val 
    370                 375                 380                 


Gly Tyr Gln Pro Gln Glu Leu Leu Gly Lys Asn Ile Val Glu Phe Cys 
385                 390                 395                 400 


His Pro Glu Asp Gln Gln Leu Leu Arg Asp Ser Phe Gln Gln Val Val 
                405                 410                 415     


Lys Leu Lys Gly Gln Val Leu Ser Val Met Phe Arg Phe Arg Ser Lys 
            420                 425                 430         


Asn Gln Glu Trp Leu Trp Met Arg Xaa Ser Ser Phe Xaa Phe Gln Asn 
        435                 440                 445             


Pro Tyr Ser Asp Glu Ile Glu Tyr Ile Ile Cys Xaa Asn Xaa Asn Val 
    450                 455                 460                 


Lys Asn Ser Ser Gln Glu Pro Arg Pro Xaa Leu Ser Asn Xaa Ile Gln 
465                 470                 475                 480 


Arg Pro Gln Leu Gly Pro Xaa Ala Asn Leu Pro Leu Glu Met Gly Ser 
                485                 490                 495     


Gly Gln Leu Ala Pro Arg Gln Gln Gln Gln Gln Xaa Glu Leu Asp Met 
            500                 505                 510         


Val Pro Gly Arg Asp Gly Leu Ala Ser Tyr Asn His Ser Gln Val Val 
        515                 520                 525             


Gln Pro Val Xaa Xaa Xaa Gly Pro Glu His Ser Lys Pro Leu Glu Lys 
    530                 535                 540                 


Ser Asp Gly Leu Phe Ala Gln Asp Arg Asp Pro Arg Phe Ser Glu Ile 
545                 550                 555                 560 


Tyr His Asn Ile Asn Ala Asp Gln Ser Lys Gly Ile Ser Ser Ser Xaa 
                565                 570                 575     


Val Pro Ala Xaa Gln Gln Leu Phe Ser Gln Gly Asn Xaa Phe Pro Pro 
            580                 585                 590         


Xaa Pro Arg Pro Ala Glu Asn Phe Arg Asn Ser Gly Leu Ala Pro Pro 
        595                 600                 605             


Val Xaa Ile Val Gln Pro Ser Ala Ser Ala Gly Gln Met Leu Ala Gln 
    610                 615                 620                 


Ile Ser Arg His Ser Asn Pro Xaa Gln Gly Ala Xaa Pro Xaa Trp Xaa 
625                 630                 635                 640 


Pro Xaa Xaa Arg Ser Gly Phe Ser Ala Gln Gln Val Ala Xaa Gln Ala 
                645                 650                 655     


Xaa Ala Lys Xaa Arg Xaa Ser Gln Phe Gly Val Gly Ser Phe Gln Xaa 
            660                 665                 670         


Pro Ser Ser Phe Ser Ser Met Ser Leu Pro Gly Ala Pro Xaa Ala Ser 
        675                 680                 685             


Pro Gly Ala Ala Ala Tyr Pro Ser Leu Xaa Asn Arg Gly Ser Asn Phe 
    690                 695                 700                 


Ala Pro Glu Xaa Gly Gln Xaa Ala Gly Gln Phe Gln Xaa Arg Xaa Ala 
705                 710                 715                 720 


Glu Gly Val Gly Val Trp Pro Gln Trp Gln Gly Gln Gln Pro His His 
                725                 730                 735     


Arg Ser Ser Ser Ser Glu Gln His Val Gln Gln Pro Pro Ala Gln Gln 
            740                 745                 750         


Pro Gly Gln Pro Glu Val Phe Gln Glu Met Leu Ser Met Leu Gly Asp 
        755                 760                 765             


Gln Ser Asn Ser Tyr Asn Asn Glu Glu Phe Pro Asp Leu Xaa Met Phe 
    770                 775                 780                 


Pro Pro Phe Ser Glu 
785                 


<210> 3228
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<400> 3228
Met Ala Ala Xaa Xaa Ala Asn Pro Glu Met Xaa Ser Asp Val Pro Ser 
1               5                   10                  15      


Leu Gly Pro Ala Ile Ala Ser Gly Asn Ser Gly Pro Gly Ile Gln Gly 
            20                  25                  30          


Gly Gly Ala Ile Val Gln Arg Ala Ile Lys Arg Arg Pro Gly Trp Ser 
        35                  40                  45              


Leu Ala Val Val Ala Gln Ala 
    50                  55  


<210> 3229
<211> 775
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<400> 3229
Met Xaa Ser Asp Val Pro Ser Leu Gly Pro Ala Ile Ala Ser Gly Asn 
1               5                   10                  15      


Ser Gly Pro Gly Ile Gln Gly Gly Gly Ala Ile Val Gln Arg Ala Ile 
            20                  25                  30          


Lys Arg Arg Pro Gly Leu Asp Phe Asp Asp Asp Gly Glu Gly Asn Ser 
        35                  40                  45              


Lys Phe Leu Arg Cys Asp Asp Asp Gln Met Ser Asn Asp Lys Glu Arg 
    50                  55                  60                  


Phe Ala Arg Ser Asp Asp Glu Gln Ser Ser Ala Asp Lys Glu Arg Leu 
65                  70                  75                  80  


Ala Arg Glu Asn His Ser Glu Ile Glu Arg Arg Arg Arg Asn Lys Met 
                85                  90                  95      


Xaa Ala Tyr Ile Xaa Glu Leu Ser Asp Met Val Pro Xaa Cys Ser Ala 
            100                 105                 110         


Leu Ala Arg Lys Pro Asp Lys Leu Xaa Ile Leu Arg Met Ala Val Ser 
        115                 120                 125             


His Met Lys Ser Leu Arg Gly Xaa Gly Asn Xaa Ser Xaa Asp Gly Ser 
    130                 135                 140                 


Tyr Lys Pro Ser Phe Leu Xaa Asp Gln Glu Leu Lys His Leu Ile Leu 
145                 150                 155                 160 


Glu Ala Ala Asp Gly Phe Leu Phe Ile Val Ser Cys Glu Xaa Gly Arg 
                165                 170                 175     


Val Val Tyr Val Ser Asp Ser Val Xaa Pro Val Leu Asn Gln Pro Gln 
            180                 185                 190         


Ser Glu Trp Phe Gly Ser Xaa Leu Tyr Asp Gln Val His Pro Asp Asp 
        195                 200                 205             


Val Asp Lys Leu Arg Glu Gln Leu Ser Xaa Ser Glu Asn Ala Leu Xaa 
    210                 215                 220                 


Gly Arg Ile Leu Asp Leu Lys Xaa Gly Xaa Val Lys Lys Glu Gly Gln 
225                 230                 235                 240 


Gln Ser Ser Met Arg Met Cys Met Gly Ser Arg Arg Ser Phe Ile Cys 
                245                 250                 255     


Arg Met Arg Cys Gly Ser Ser Ser Val Asp Pro Val Ser Val Asn Arg 
            260                 265                 270         


Leu Ser Phe Val Arg Asn Arg Cys Arg Asn Gly Leu Gly Ser Val Lys 
        275                 280                 285             


Asp Gly Glu Pro His Phe Val Val Val His Cys Xaa Gly Tyr Ile Lys 
    290                 295                 300                 


Ala Trp Pro Pro Ala Asp Asp Asp Pro Glu Ala Gly Gln Gly Ser Lys 
305                 310                 315                 320 


Phe Cys Leu Val Ala Ile Gly Arg Leu Gln Val Xaa Ser Ser Pro Asn 
                325                 330                 335     


Cys Xaa Asp Met Ser Asn Val Cys Gln Pro Xaa Glu Phe Ile Ser Arg 
            340                 345                 350         


His Asn Ile Glu Gly Ile Phe Xaa Phe Val Asp His Arg Cys Val Ala 
        355                 360                 365             


Xaa Val Gly Tyr Gln Pro Gln Glu Leu Leu Gly Lys Asn Ile Val Glu 
    370                 375                 380                 


Phe Cys His Pro Glu Asp Gln Gln Leu Leu Arg Asp Ser Phe Gln Gln 
385                 390                 395                 400 


Val Val Lys Leu Lys Gly Gln Val Leu Ser Val Met Phe Arg Phe Arg 
                405                 410                 415     


Ser Lys Asn Gln Glu Trp Leu Trp Met Arg Xaa Ser Ser Phe Xaa Phe 
            420                 425                 430         


Gln Asn Pro Tyr Ser Asp Glu Ile Glu Tyr Ile Ile Cys Xaa Asn Xaa 
        435                 440                 445             


Asn Val Lys Asn Ser Ser Gln Glu Pro Arg Pro Xaa Leu Ser Asn Xaa 
    450                 455                 460                 


Ile Gln Arg Pro Gln Leu Gly Pro Xaa Ala Asn Leu Pro Leu Glu Met 
465                 470                 475                 480 


Gly Ser Gly Gln Leu Ala Pro Arg Gln Gln Gln Gln Gln Xaa Glu Leu 
                485                 490                 495     


Asp Met Val Pro Gly Arg Asp Gly Leu Ala Ser Tyr Asn His Ser Gln 
            500                 505                 510         


Val Val Gln Pro Val Xaa Xaa Xaa Gly Pro Glu His Ser Lys Pro Leu 
        515                 520                 525             


Glu Lys Ser Asp Gly Leu Phe Ala Gln Asp Arg Asp Pro Arg Phe Ser 
    530                 535                 540                 


Glu Ile Tyr His Asn Ile Asn Ala Asp Gln Ser Lys Gly Ile Ser Ser 
545                 550                 555                 560 


Ser Xaa Val Pro Ala Xaa Gln Gln Leu Phe Ser Gln Gly Asn Xaa Phe 
                565                 570                 575     


Pro Pro Xaa Pro Arg Pro Ala Glu Asn Phe Arg Asn Ser Gly Leu Ala 
            580                 585                 590         


Pro Pro Val Xaa Ile Val Gln Pro Ser Ala Ser Ala Gly Gln Met Leu 
        595                 600                 605             


Ala Gln Ile Ser Arg His Ser Asn Pro Xaa Gln Gly Ala Xaa Pro Xaa 
    610                 615                 620                 


Trp Xaa Pro Xaa Xaa Arg Ser Gly Phe Ser Ala Gln Gln Val Ala Xaa 
625                 630                 635                 640 


Gln Ala Xaa Ala Lys Xaa Arg Xaa Ser Gln Phe Gly Val Gly Ser Phe 
                645                 650                 655     


Gln Xaa Pro Ser Ser Phe Ser Ser Met Ser Leu Pro Gly Ala Pro Xaa 
            660                 665                 670         


Ala Ser Pro Gly Ala Ala Ala Tyr Pro Ser Leu Xaa Asn Arg Gly Ser 
        675                 680                 685             


Asn Phe Ala Pro Glu Xaa Gly Gln Xaa Ala Gly Gln Phe Gln Xaa Arg 
    690                 695                 700                 


Xaa Ala Glu Gly Val Gly Val Trp Pro Gln Trp Gln Gly Gln Gln Pro 
705                 710                 715                 720 


His His Arg Ser Ser Ser Ser Glu Gln His Val Gln Gln Pro Pro Ala 
                725                 730                 735     


Gln Gln Pro Gly Gln Pro Glu Val Phe Gln Glu Met Leu Ser Met Leu 
            740                 745                 750         


Gly Asp Gln Ser Asn Ser Tyr Asn Asn Glu Glu Phe Pro Asp Leu Xaa 
        755                 760                 765             


Met Phe Pro Pro Phe Ser Glu 
    770                 775 


<210> 3230
<211> 706
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<400> 3230
Met Ala Ser Asp Ile Pro Gly Ser Val Xaa Leu Pro Val Ala Pro Met 
1               5                   10                  15      


Ala Ala Xaa Gly Gln Val Arg Met Ala Gly Ala Met Pro Ala Arg Gly 
            20                  25                  30          


Gly Lys Arg Arg Ser Gly Met Asp Phe Asp Asp Glu Asp Gly Glu Gly 
        35                  40                  45              


Pro Ser Lys Phe Ser Arg Glu Asn His Ser Glu Ile Glu Arg Arg Arg 
    50                  55                  60                  


Arg Asn Lys Met Xaa Gln Tyr Ile Xaa Glu Leu Ser Asp Met Val Pro 
65                  70                  75                  80  


Xaa Cys Ser Ala Leu Ala Arg Lys Pro Asp Lys Leu Xaa Ile Leu Arg 
                85                  90                  95      


Met Ala Val Ser His Met Lys Ser Met Arg Gly Xaa Gly Asn Lys Ser 
            100                 105                 110         


Xaa Asp Gly Ala Tyr Lys Pro Ser Phe Leu Xaa Glu Gln Glu Leu Lys 
        115                 120                 125             


His Leu Ile Leu Glu Ala Ala Asp Gly Phe Leu Phe Val Val Ala Ala 
    130                 135                 140                 


Glu Xaa Gly Arg Val Ile Tyr Val Ser Asp Ser Val Xaa Pro Val Leu 
145                 150                 155                 160 


Asn Gln Pro Gln Ser Glu Trp Phe Gly Ser Xaa Leu Tyr Glu Gln Val 
                165                 170                 175     


His Pro Asp Asp Val Glu Lys Leu Arg Glu Gln Leu Cys Xaa Ser Glu 
            180                 185                 190         


Asn Ser Met Xaa Gly Arg Ile Leu Asp Leu Lys Xaa Gly Xaa Val Lys 
        195                 200                 205             


Lys Glu Gly Gln Gln Ser Ser Met Arg Met Cys Met Gly Ser Arg Arg 
    210                 215                 220                 


Ser Phe Ile Cys Arg Met Arg Cys Gly Asn Ala Pro Leu Asp His Leu 
225                 230                 235                 240 


Pro Leu Asn Arg Ile Xaa Xaa Met Arg Lys Arg Phe Arg Asn Gly Leu 
                245                 250                 255     


Gly Pro Val Lys Glu Gly Glu Ala Gln Tyr Ala Val Val His Cys Xaa 
            260                 265                 270         


Gly Tyr Ile Lys Ala Trp Pro Pro Ala Gly Met Xaa Ile Pro Glu Glu 
        275                 280                 285             


Asp Ala Asp Val Gly Gln Gly Ser Lys Tyr Cys Leu Val Ala Ile Gly 
    290                 295                 300                 


Arg Leu Gln Val Xaa Ser Ser Pro Val Cys Met Asp Met Asn Gly Met 
305                 310                 315                 320 


Ser Val Pro Xaa Glu Phe Leu Ser Arg His Asn Ser Asp Gly Ile Ile 
                325                 330                 335     


Xaa Phe Val Asp Pro Arg Cys Ile Ser Val Ile Gly Tyr Gln Pro Gln 
            340                 345                 350         


Asp Leu Leu Gly Lys Asp Ile Leu Glu Phe Cys His Pro Glu Asp Gln 
        355                 360                 365             


Ser His Leu Arg Glu Ser Phe Gln Gln Val Val Lys Leu Lys Gly Gln 
    370                 375                 380                 


Val Leu Ser Val Met Tyr Arg Phe Arg Xaa Lys Asn Arg Glu Trp Met 
385                 390                 395                 400 


Leu Ile Arg Xaa Ser Ser Phe Xaa Phe Gln Asn Pro Tyr Ser Asp Glu 
                405                 410                 415     


Ile Glu Tyr Ile Ile Cys Xaa Asn Xaa Asn Val Lys Gln Leu Gln Gln 
            420                 425                 430         


Gln Gln Ala Glu Leu Glu Val His Gln Arg Asp Gly Leu Ser Ser Tyr 
        435                 440                 445             


Asp Leu Ser Gln Val Pro Val Pro Asn Leu Pro Ala Gly Val His Glu 
    450                 455                 460                 


Ala Gly Lys Ser Val Glu Lys Ala Asp Ala Ile Phe Ser Gln Glu Arg 
465                 470                 475                 480 


Asp Pro Arg Phe Ala Glu Met Phe Ala Gly Ile Ser Ala Ser Glu Lys 
                485                 490                 495     


Lys Met Met Ser Ser Ala Ser Ala Ala Gly Xaa Gln Gln Ile Tyr Ser 
            500                 505                 510         


Gln Gly Ser Pro Phe Pro Ser Gly His Ser Gly Lys Ala Phe Ser Ser 
        515                 520                 525             


Ser Val Val His Val Pro Gly Val Asn Asp Ile Gln Ser Ser Ser Ser 
    530                 535                 540                 


Xaa Gly Gln Asn Met Ser Gln Ile Ser Arg Gln Leu Asn Gln Ser Gln 
545                 550                 555                 560 


Val Ala Trp Xaa Gly Ser Arg Pro Pro Phe Pro Gly Gln Gln Ile Pro 
                565                 570                 575     


Ser Gln Ser Ser Lys Xaa Gln Ser Ser Pro Phe Gly Ile Gly Xaa Ser 
            580                 585                 590         


His Xaa Tyr Pro Ala Asp Pro Ser Ser Tyr Ser Pro Leu Ser Ser Pro 
        595                 600                 605             


Ala Xaa Ser Ser Pro Ser Gly Asn Ala Tyr Ser Ser Leu Ala Asn Arg 
    610                 615                 620                 


Xaa Pro Gly Phe Ala Glu Ser Gly Gln Ser Ser Gly Gln Phe Gln Gly 
625                 630                 635                 640 


Arg Pro Ser Glu Val Trp Ser Gln Trp Gln Ser Gln His His Gly Gln 
                645                 650                 655     


Gln Ser Gly Glu Gln His Ser His Gln Gln Pro Gly Gln Xaa Glu Val 
            660                 665                 670         


Phe Gln Asp Met Leu Pro Met Pro Gly Asp Pro Xaa Gln Gly Xaa Gly 
        675                 680                 685             


Asn Tyr Asn Ile Glu Asp Phe Ala Asp Leu Gly Met Phe Pro Pro Phe 
    690                 695                 700                 


Ser Glu 
705     


<210> 3231
<211> 716
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<400> 3231
Met Ala Xaa Pro Ala Ala Val Asn Pro Pro Glu Met Ala Ser Asp Ile 
1               5                   10                  15      


Pro Gly Ser Val Xaa Leu Pro Val Ala Pro Met Ala Ala Xaa Gly Gln 
            20                  25                  30          


Val Arg Met Ala Gly Ala Met Pro Ala Arg Gly Gly Lys Arg Arg Ser 
        35                  40                  45              


Gly Met Asp Phe Asp Asp Glu Asp Gly Glu Gly Pro Ser Lys Phe Ser 
    50                  55                  60                  


Arg Glu Asn His Ser Glu Ile Glu Arg Arg Arg Arg Asn Lys Met Xaa 
65                  70                  75                  80  


Gln Tyr Ile Xaa Glu Leu Ser Asp Met Val Pro Xaa Cys Ser Ala Leu 
                85                  90                  95      


Ala Arg Lys Pro Asp Lys Leu Xaa Ile Leu Arg Met Ala Val Ser His 
            100                 105                 110         


Met Lys Ser Met Arg Gly Xaa Gly Asn Lys Ser Xaa Asp Gly Ala Tyr 
        115                 120                 125             


Lys Pro Ser Phe Leu Xaa Glu Gln Glu Leu Lys His Leu Ile Leu Glu 
    130                 135                 140                 


Ala Ala Asp Gly Phe Leu Phe Val Val Ala Ala Glu Xaa Gly Arg Val 
145                 150                 155                 160 


Ile Tyr Val Ser Asp Ser Val Xaa Pro Val Leu Asn Gln Pro Gln Ser 
                165                 170                 175     


Glu Trp Phe Gly Ser Xaa Leu Tyr Glu Gln Val His Pro Asp Asp Val 
            180                 185                 190         


Glu Lys Leu Arg Glu Gln Leu Cys Xaa Ser Glu Asn Ser Met Xaa Gly 
        195                 200                 205             


Arg Ile Leu Asp Leu Lys Xaa Gly Xaa Val Lys Lys Glu Gly Gln Gln 
    210                 215                 220                 


Ser Ser Met Arg Met Cys Met Gly Ser Arg Arg Ser Phe Ile Cys Arg 
225                 230                 235                 240 


Met Arg Cys Gly Asn Ala Pro Leu Asp His Leu Pro Leu Asn Arg Ile 
                245                 250                 255     


Xaa Xaa Met Arg Lys Arg Phe Arg Asn Gly Leu Gly Pro Val Lys Glu 
            260                 265                 270         


Gly Glu Ala Gln Tyr Ala Val Val His Cys Xaa Gly Tyr Ile Lys Ala 
        275                 280                 285             


Trp Pro Pro Ala Gly Met Xaa Ile Pro Glu Glu Asp Ala Asp Val Gly 
    290                 295                 300                 


Gln Gly Ser Lys Tyr Cys Leu Val Ala Ile Gly Arg Leu Gln Val Xaa 
305                 310                 315                 320 


Ser Ser Pro Val Cys Met Asp Met Asn Gly Met Ser Val Pro Xaa Glu 
                325                 330                 335     


Phe Leu Ser Arg His Asn Ser Asp Gly Ile Ile Xaa Phe Val Asp Pro 
            340                 345                 350         


Arg Cys Ile Ser Val Ile Gly Tyr Gln Pro Gln Asp Leu Leu Gly Lys 
        355                 360                 365             


Asp Ile Leu Glu Phe Cys His Pro Glu Asp Gln Ser His Leu Arg Glu 
    370                 375                 380                 


Ser Phe Gln Gln Val Val Lys Leu Lys Gly Gln Val Leu Ser Val Met 
385                 390                 395                 400 


Tyr Arg Phe Arg Xaa Lys Asn Arg Glu Trp Met Leu Ile Arg Xaa Ser 
                405                 410                 415     


Ser Phe Xaa Phe Gln Asn Pro Tyr Ser Asp Glu Ile Glu Tyr Ile Ile 
            420                 425                 430         


Cys Xaa Asn Xaa Asn Val Lys Gln Leu Gln Gln Gln Gln Ala Glu Leu 
        435                 440                 445             


Glu Val His Gln Arg Asp Gly Leu Ser Ser Tyr Asp Leu Ser Gln Val 
    450                 455                 460                 


Pro Val Pro Asn Leu Pro Ala Gly Val His Glu Ala Gly Lys Ser Val 
465                 470                 475                 480 


Glu Lys Ala Asp Ala Ile Phe Ser Gln Glu Arg Asp Pro Arg Phe Ala 
                485                 490                 495     


Glu Met Phe Ala Gly Ile Ser Ala Ser Glu Lys Lys Met Met Ser Ser 
            500                 505                 510         


Ala Ser Ala Ala Gly Xaa Gln Gln Ile Tyr Ser Gln Gly Ser Pro Phe 
        515                 520                 525             


Pro Ser Gly His Ser Gly Lys Ala Phe Ser Ser Ser Val Val His Val 
    530                 535                 540                 


Pro Gly Val Asn Asp Ile Gln Ser Ser Ser Ser Xaa Gly Gln Asn Met 
545                 550                 555                 560 


Ser Gln Ile Ser Arg Gln Leu Asn Gln Ser Gln Val Ala Trp Xaa Gly 
                565                 570                 575     


Ser Arg Pro Pro Phe Pro Gly Gln Gln Ile Pro Ser Gln Ser Ser Lys 
            580                 585                 590         


Xaa Gln Ser Ser Pro Phe Gly Ile Gly Xaa Ser His Xaa Tyr Pro Ala 
        595                 600                 605             


Asp Pro Ser Ser Tyr Ser Pro Leu Ser Ser Pro Ala Xaa Ser Ser Pro 
    610                 615                 620                 


Ser Gly Asn Ala Tyr Ser Ser Leu Ala Asn Arg Xaa Pro Gly Phe Ala 
625                 630                 635                 640 


Glu Ser Gly Gln Ser Ser Gly Gln Phe Gln Gly Arg Pro Ser Glu Val 
                645                 650                 655     


Trp Ser Gln Trp Gln Ser Gln His His Gly Gln Gln Ser Gly Glu Gln 
            660                 665                 670         


His Ser His Gln Gln Pro Gly Gln Xaa Glu Val Phe Gln Asp Met Leu 
        675                 680                 685             


Pro Met Pro Gly Asp Pro Arg Asn Glu Trp Trp Ser Pro His Ser Arg 
    690                 695                 700                 


Gln His Phe Arg Gln Pro Ile Ser Tyr Ala Arg Met 
705                 710                 715     


<210> 3232
<211> 717
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<400> 3232
Met Ala Xaa Pro Ala Ala Val Asn Pro Pro Glu Met Ala Ser Asp Ile 
1               5                   10                  15      


Pro Gly Ser Val Xaa Leu Pro Val Ala Pro Met Ala Ala Xaa Gly Gln 
            20                  25                  30          


Val Arg Met Ala Gly Ala Met Pro Ala Arg Gly Gly Lys Arg Arg Ser 
        35                  40                  45              


Gly Met Asp Phe Asp Asp Glu Asp Gly Glu Gly Pro Ser Lys Phe Ser 
    50                  55                  60                  


Arg Glu Asn His Ser Glu Ile Glu Arg Arg Arg Arg Asn Lys Met Xaa 
65                  70                  75                  80  


Gln Tyr Ile Xaa Glu Leu Ser Asp Met Val Pro Xaa Cys Ser Ala Leu 
                85                  90                  95      


Ala Arg Lys Pro Asp Lys Leu Xaa Ile Leu Arg Met Ala Val Ser His 
            100                 105                 110         


Met Lys Ser Met Arg Gly Xaa Gly Asn Lys Ser Xaa Asp Gly Ala Tyr 
        115                 120                 125             


Lys Pro Ser Phe Leu Xaa Glu Gln Glu Leu Lys His Leu Ile Leu Glu 
    130                 135                 140                 


Ala Ala Asp Gly Phe Leu Phe Val Val Ala Ala Glu Xaa Gly Arg Val 
145                 150                 155                 160 


Ile Tyr Val Ser Asp Ser Val Xaa Pro Val Leu Asn Gln Pro Gln Ser 
                165                 170                 175     


Glu Trp Phe Gly Ser Xaa Leu Tyr Glu Gln Val His Pro Asp Asp Val 
            180                 185                 190         


Glu Lys Leu Arg Glu Gln Leu Cys Xaa Ser Glu Asn Ser Met Xaa Gly 
        195                 200                 205             


Arg Ile Leu Asp Leu Lys Xaa Gly Xaa Val Lys Lys Glu Gly Gln Gln 
    210                 215                 220                 


Ser Ser Met Arg Met Cys Met Gly Ser Arg Arg Ser Phe Ile Cys Arg 
225                 230                 235                 240 


Met Arg Cys Gly Asn Ala Pro Leu Asp His Leu Pro Leu Asn Arg Ile 
                245                 250                 255     


Xaa Xaa Met Arg Lys Arg Phe Arg Asn Gly Leu Gly Pro Val Lys Glu 
            260                 265                 270         


Gly Glu Ala Gln Tyr Ala Val Val His Cys Xaa Gly Tyr Ile Lys Ala 
        275                 280                 285             


Trp Pro Pro Ala Gly Met Xaa Ile Pro Glu Glu Asp Ala Asp Val Gly 
    290                 295                 300                 


Gln Gly Ser Lys Tyr Cys Leu Val Ala Ile Gly Arg Leu Gln Val Xaa 
305                 310                 315                 320 


Ser Ser Pro Val Cys Met Asp Met Asn Gly Met Ser Val Pro Xaa Glu 
                325                 330                 335     


Phe Leu Ser Arg His Asn Ser Asp Gly Ile Ile Xaa Phe Val Asp Pro 
            340                 345                 350         


Arg Cys Ile Ser Val Ile Gly Tyr Gln Pro Gln Asp Leu Leu Gly Lys 
        355                 360                 365             


Asp Ile Leu Glu Phe Cys His Pro Glu Asp Gln Ser His Leu Arg Glu 
    370                 375                 380                 


Ser Phe Gln Gln Val Val Lys Leu Lys Gly Gln Val Leu Ser Val Met 
385                 390                 395                 400 


Tyr Arg Phe Arg Xaa Lys Asn Arg Glu Trp Met Leu Ile Arg Xaa Ser 
                405                 410                 415     


Ser Phe Xaa Phe Gln Asn Pro Tyr Ser Asp Glu Ile Glu Tyr Ile Ile 
            420                 425                 430         


Cys Xaa Asn Xaa Asn Val Lys Gln Leu Gln Gln Gln Gln Ala Glu Leu 
        435                 440                 445             


Glu Val His Gln Arg Asp Gly Leu Ser Ser Tyr Asp Leu Ser Gln Val 
    450                 455                 460                 


Pro Val Pro Asn Leu Pro Ala Gly Val His Glu Ala Gly Lys Ser Val 
465                 470                 475                 480 


Glu Lys Ala Asp Ala Ile Phe Ser Gln Glu Arg Asp Pro Arg Phe Ala 
                485                 490                 495     


Glu Met Phe Ala Gly Ile Ser Ala Ser Glu Lys Lys Met Met Ser Ser 
            500                 505                 510         


Ala Ser Ala Ala Gly Xaa Gln Gln Ile Tyr Ser Gln Gly Ser Pro Phe 
        515                 520                 525             


Pro Ser Gly His Ser Gly Lys Ala Phe Ser Ser Ser Val Val His Val 
    530                 535                 540                 


Pro Gly Val Asn Asp Ile Gln Ser Ser Ser Ser Xaa Gly Gln Asn Met 
545                 550                 555                 560 


Ser Gln Ile Ser Arg Gln Leu Asn Gln Ser Gln Val Ala Trp Xaa Gly 
                565                 570                 575     


Ser Arg Pro Pro Phe Pro Gly Gln Gln Ile Pro Ser Gln Ser Ser Lys 
            580                 585                 590         


Xaa Gln Ser Ser Pro Phe Gly Ile Gly Xaa Ser His Xaa Tyr Pro Ala 
        595                 600                 605             


Asp Pro Ser Ser Tyr Ser Pro Leu Ser Ser Pro Ala Xaa Ser Ser Pro 
    610                 615                 620                 


Ser Gly Asn Ala Tyr Ser Ser Leu Ala Asn Arg Xaa Pro Gly Phe Ala 
625                 630                 635                 640 


Glu Ser Gly Gln Ser Ser Gly Gln Phe Gln Gly Arg Pro Ser Glu Val 
                645                 650                 655     


Trp Ser Gln Trp Gln Ser Gln His His Gly Gln Gln Ser Gly Glu Gln 
            660                 665                 670         


His Ser His Gln Gln Pro Gly Gln Xaa Glu Val Phe Gln Asp Met Leu 
        675                 680                 685             


Pro Met Pro Gly Asp Pro Xaa Gln Gly Xaa Gly Asn Tyr Asn Ile Glu 
    690                 695                 700                 


Asp Phe Ala Asp Leu Gly Met Phe Pro Pro Phe Ser Glu 
705                 710                 715         


<210> 3233
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<400> 3233
Met Arg Met Cys Met Gly Ser Arg Arg Ser Phe Ile Cys Arg Met Arg 
1               5                   10                  15      


Cys Gly Asn Ala Pro Leu Asp His Leu Pro Leu Asn Arg Ile Xaa Xaa 
            20                  25                  30          


Met Arg Lys Arg Phe Arg Asn Gly Leu Gly Pro Val Lys Glu Gly Glu 
        35                  40                  45              


Ala Gln Tyr Ala Val Val His Cys Xaa Gly Tyr Ile Lys Ala Trp Pro 
    50                  55                  60                  


Pro Ala Gly Met Xaa Ile Pro Glu Glu Asp Ala Asp Val Gly Gln Gly 
65                  70                  75                  80  


Ser Lys Tyr Cys Leu Val Ala Ile Gly Arg Leu Gln Val Xaa Ser Ser 
                85                  90                  95      


Pro Val Cys Met Asp Met Asn Gly Met Ser Val Pro Xaa Glu Phe Leu 
            100                 105                 110         


Ser Arg His Asn Ser Asp Gly Ile Ile Xaa Phe Val Asp Pro Arg Cys 
        115                 120                 125             


Ile Ser 
    130 


<210> 3234
<211> 23
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<400> 3234
Met Ala Asp Gln Arg Met Asp Ile Ser Ser Xaa Ile Ser Asp Phe Met 
1               5                   10                  15      


Ser Pro Gly Pro Xaa Asp Leu 
            20              


<210> 3235
<211> 59
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 3235
Met Ala Asp Gln Arg Met Asp Ile Ser Ser Xaa Ile Ser Asp Phe Met 
1               5                   10                  15      


Ser Pro Gly Pro Xaa Asp Leu Leu Ser Ser Ser Leu Gly Xaa Ser Gly 
            20                  25                  30          


Val Asp Cys Asn Arg Lys Arg Lys Gly Ser Ser Xaa Asp Tyr Gln Glu 
        35                  40                  45              


Ser Met Asp Xaa Asp Lys Asp Asp Pro His Gly 
    50                  55                  


<210> 3236
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 3236
Met Ala Asp Gln Arg Met Asp Ile Ser Ser Xaa Ile Ser Asp Phe Met 
1               5                   10                  15      


Ser Pro Gly Pro Xaa Asp Leu Leu Ser Ser Ser Leu Gly Xaa Ser Gly 
            20                  25                  30          


Val Asp Cys Asn Arg Lys Arg Lys Gly Ser Ser Xaa Asp Tyr Gln Glu 
        35                  40                  45              


Ser Met Asp Xaa Asp Lys Asp Asp Pro His Gly Arg Leu Glu Tyr Xaa 
    50                  55                  60                  


Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu Ala 
65                  70                  75      


<210> 3237
<211> 101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<400> 3237
Met Ala Asp Gln Arg Met Asp Ile Ser Ser Xaa Ile Ser Asp Phe Met 
1               5                   10                  15      


Ser Pro Gly Pro Xaa Asp Leu Leu Ser Ser Ser Leu Gly Xaa Ser Gly 
            20                  25                  30          


Val Asp Cys Asn Arg Lys Arg Lys Gly Ser Ser Xaa Asp Tyr Gln Glu 
        35                  40                  45              


Ser Met Asp Xaa Asp Lys Asp Asp Pro His Gly Arg Leu Glu Tyr Xaa 
    50                  55                  60                  


Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu Ala His Ser Gln Ile 
65                  70                  75                  80  


Glu Lys Arg Arg Arg Asp Lys Met Asn Ser Phe Ile Asp Glu Leu Ala 
                85                  90                  95      


Ser Leu Val Pro Xaa 
            100     


<210> 3238
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<400> 3238
Met Ala Asp Gln Arg Met Asp Ile Ser Ser Xaa Ile Ser Asp Phe Met 
1               5                   10                  15      


Ser Pro Gly Pro Xaa Asp Leu Leu Ser Ser Ser Leu Gly Xaa Ser Gly 
            20                  25                  30          


Val Asp Cys Asn Arg Lys Arg Lys Gly Ser Ser Xaa Asp Tyr Gln Glu 
        35                  40                  45              


Ser Met Asp Xaa Asp Lys Asp Asp Pro His Gly Arg Leu Glu Tyr Xaa 
    50                  55                  60                  


Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu Ala His Ser Gln Ile 
65                  70                  75                  80  


Glu Lys Arg Arg Arg Asp Lys Met Asn Ser Phe Ile Asp Glu Leu Ala 
                85                  90                  95      


Ser Leu Val Pro Xaa Cys Asn Ala Met Ser Arg Lys Leu Asp Lys Leu 
            100                 105                 110         


Xaa Val Leu Arg Met Ala Val Gln His Met Lys Xaa Leu Arg Gly Ala 
        115                 120                 125             


Xaa Asn Pro Tyr Xaa Glu Ala 
    130                 135 


<210> 3239
<211> 625
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<400> 3239
Met Ala Asp Gln Arg Met Asp Ile Ser Ser Xaa Ile Ser Asp Phe Met 
1               5                   10                  15      


Ser Pro Gly Pro Xaa Asp Leu Leu Ser Ser Ser Leu Gly Xaa Ser Gly 
            20                  25                  30          


Val Asp Cys Asn Arg Lys Arg Lys Gly Ser Ser Xaa Asp Tyr Gln Glu 
        35                  40                  45              


Ser Met Asp Xaa Asp Lys Asp Asp Pro His Gly Arg Leu Glu Tyr Xaa 
    50                  55                  60                  


Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu Ala His Ser Gln Ile 
65                  70                  75                  80  


Glu Lys Arg Arg Arg Asp Lys Met Asn Ser Phe Ile Asp Glu Leu Ala 
                85                  90                  95      


Ser Leu Val Pro Xaa Cys Asn Ala Met Ser Arg Lys Leu Asp Lys Leu 
            100                 105                 110         


Xaa Val Leu Arg Met Ala Val Gln His Met Lys Xaa Leu Arg Gly Ala 
        115                 120                 125             


Xaa Asn Pro Tyr Xaa Glu Ala Asn Tyr Lys Pro Xaa Phe Leu Ser Asp 
    130                 135                 140                 


Asp Glu Leu Lys His Leu Ile Leu Arg Ala Ala Asp Gly Phe Leu Phe 
145                 150                 155                 160 


Val Val Gly Cys Asp Arg Gly Lys Ile Leu Phe Val Ser Glu Ser Val 
                165                 170                 175     


Phe Lys Ile Leu Asn Tyr Ser Gln Asn Asp Leu Ile Gly Gln Ser Leu 
            180                 185                 190         


Phe Asp Tyr Leu His Pro Lys Asp Ile Ala Lys Val Lys Glu Gln Leu 
        195                 200                 205             


Ser Ser Ser Asp Xaa Ala Pro Arg Glu Arg Leu Ile Asp Ala Lys Xaa 
    210                 215                 220                 


Gly Leu Pro Val Lys Xaa Asp Ile Xaa Pro Gly Pro Ser Arg Leu Cys 
225                 230                 235                 240 


Ser Gly Ala Arg Arg Ser Phe Phe Cys Arg Met Lys Cys Asn Arg Pro 
                245                 250                 255     


Ser Val Lys Val Glu Asp Lys Asp Phe Pro Ser Xaa Cys Ser Lys Lys 
            260                 265                 270         


Lys Asp Arg Lys Ser Phe Cys Xaa Ile His Ser Xaa Gly Tyr Leu Lys 
        275                 280                 285             


Ser Trp Pro Pro Xaa Lys Met Gly Leu Asp Glu Asp Asn Glu Pro Asp 
    290                 295                 300                 


Asn Glu Gly Cys Asn Leu Ser Cys Leu Val Ala Ile Gly Arg Leu His 
305                 310                 315                 320 


Ser His Val Val Pro Gln Pro Val Asn Gly Glu Ile Arg Val Lys Ser 
                325                 330                 335     


Met Glu Tyr Val Ser Arg His Ala Ile Asp Gly Lys Phe Val Phe Val 
            340                 345                 350         


Asp Gln Arg Ala Xaa Ala Ile Leu Ala Tyr Leu Pro Gln Glu Leu Leu 
        355                 360                 365             


Gly Xaa Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp Ile Gly His Leu 
    370                 375                 380                 


Ala Glu Cys His Arg Gln Val Leu Gln Xaa Arg Glu Lys Ile Xaa Xaa 
385                 390                 395                 400 


Asn Cys Tyr Lys Phe Lys Ile Lys Asp Gly Ser Phe Ile Xaa Leu Arg 
                405                 410                 415     


Ser Arg Trp Phe Ser Phe Met Asn Pro Trp Xaa Lys Glu Val Glu Tyr 
            420                 425                 430         


Ile Val Ser Xaa Asn Xaa Val Val Leu Ala Asn Val Leu Glu Gly Gly 
        435                 440                 445             


Asp Pro Xaa Phe Pro Gln Leu Xaa Ala Ser Pro His Ser Met Asp Ser 
    450                 455                 460                 


Met Leu Pro Ser Gly Glu Gly Gly Pro Lys Arg Xaa His Pro Xaa Val 
465                 470                 475                 480 


Pro Gly Ile Pro Gly Gly Xaa Arg Ala Gly Ala Gly Lys Ile Gly Arg 
                485                 490                 495     


Met Ile Ala Glu Glu Ile Met Glu Ile His Arg Ile Arg Gly Ser Ser 
            500                 505                 510         


Pro Ser Ser Cys Gly Ser Ser Pro Leu Asn Ile Xaa Ser Xaa Pro Pro 
        515                 520                 525             


Pro Asp Ala Ser Ser Pro Gly Gly Lys Lys Ile Leu Asn Gly Gly Xaa 
    530                 535                 540                 


Pro Asp Ile Pro Ser Ser Gly Leu Leu Ser Gly Gln Ala Gln Glu Asn 
545                 550                 555                 560 


Pro Gly Tyr Pro Tyr Ser Asp Ser Ser Ser Ile Leu Gly Glu Asn Pro 
                565                 570                 575     


His Ile Gly Ile Asp Met Ile Asp Asn Asp Gln Gly Ser Ser Ser Pro 
            580                 585                 590         


Ser Asn Asp Glu Ala Ala Met Ala Val Ile Met Ser Leu Leu Glu Ala 
        595                 600                 605             


Asp Ala Gly Leu Gly Gly Pro Val Asp Phe Ser Asp Leu Pro Trp Pro 
    610                 615                 620                 


Leu 
625 


<210> 3240
<211> 626
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<400> 3240
Met Ala Asp Gln Arg Met Asp Ile Ser Ser Xaa Ile Ser Asp Phe Met 
1               5                   10                  15      


Ser Pro Gly Pro Xaa Asp Leu Leu Ser Ser Ser Leu Gly Xaa Ser Gly 
            20                  25                  30          


Val Asp Cys Asn Arg Lys Arg Lys Gly Ser Ser Xaa Asp Tyr Gln Glu 
        35                  40                  45              


Ser Met Asp Xaa Asp Lys Asp Asp Pro His Gly Arg Leu Glu Tyr Xaa 
    50                  55                  60                  


Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu Ala His Ser Gln Ile 
65                  70                  75                  80  


Glu Lys Arg Arg Arg Asp Lys Met Asn Ser Phe Ile Asp Glu Leu Ala 
                85                  90                  95      


Ser Leu Val Pro Xaa Cys Asn Ala Met Ser Arg Lys Leu Asp Lys Leu 
            100                 105                 110         


Xaa Val Leu Arg Met Ala Val Gln His Met Lys Xaa Leu Arg Gly Ala 
        115                 120                 125             


Xaa Asn Pro Tyr Xaa Glu Ala Asn Tyr Lys Pro Xaa Phe Leu Ser Asp 
    130                 135                 140                 


Asp Glu Leu Lys His Leu Ile Leu Arg Ala Ala Asp Gly Phe Leu Phe 
145                 150                 155                 160 


Val Val Gly Cys Asp Arg Gly Lys Ile Leu Phe Val Ser Glu Ser Val 
                165                 170                 175     


Phe Lys Ile Leu Asn Tyr Ser Gln Asn Asp Leu Ile Gly Gln Ser Leu 
            180                 185                 190         


Phe Asp Tyr Leu His Pro Lys Asp Ile Ala Lys Val Lys Glu Gln Leu 
        195                 200                 205             


Ser Ser Ser Asp Xaa Ala Pro Arg Glu Arg Leu Ile Asp Ala Lys Xaa 
    210                 215                 220                 


Gly Leu Pro Val Lys Xaa Asp Ile Xaa Pro Gly Pro Ser Arg Leu Cys 
225                 230                 235                 240 


Ser Gly Ala Arg Arg Ser Phe Phe Cys Arg Met Lys Cys Asn Arg Pro 
                245                 250                 255     


Ser Val Lys Val Glu Asp Lys Asp Phe Pro Ser Xaa Cys Ser Lys Lys 
            260                 265                 270         


Lys Ala Asp Arg Lys Ser Phe Cys Xaa Ile His Ser Xaa Gly Tyr Leu 
        275                 280                 285             


Lys Ser Trp Pro Pro Xaa Lys Met Gly Leu Asp Glu Asp Asn Glu Pro 
    290                 295                 300                 


Asp Asn Glu Gly Cys Asn Leu Ser Cys Leu Val Ala Ile Gly Arg Leu 
305                 310                 315                 320 


His Ser His Val Val Pro Gln Pro Val Asn Gly Glu Ile Arg Val Lys 
                325                 330                 335     


Ser Met Glu Tyr Val Ser Arg His Ala Ile Asp Gly Lys Phe Val Phe 
            340                 345                 350         


Val Asp Gln Arg Ala Xaa Ala Ile Leu Ala Tyr Leu Pro Gln Glu Leu 
        355                 360                 365             


Leu Gly Xaa Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp Ile Gly His 
    370                 375                 380                 


Leu Ala Glu Cys His Arg Gln Val Leu Gln Xaa Arg Glu Lys Ile Xaa 
385                 390                 395                 400 


Xaa Asn Cys Tyr Lys Phe Lys Ile Lys Asp Gly Ser Phe Ile Xaa Leu 
                405                 410                 415     


Arg Ser Arg Trp Phe Ser Phe Met Asn Pro Trp Xaa Lys Glu Val Glu 
            420                 425                 430         


Tyr Ile Val Ser Xaa Asn Xaa Val Val Leu Ala Asn Val Leu Glu Gly 
        435                 440                 445             


Gly Asp Pro Xaa Phe Pro Gln Leu Xaa Ala Ser Pro His Ser Met Asp 
    450                 455                 460                 


Ser Met Leu Pro Ser Gly Glu Gly Gly Pro Lys Arg Xaa His Pro Xaa 
465                 470                 475                 480 


Val Pro Gly Ile Pro Gly Gly Xaa Arg Ala Gly Ala Gly Lys Ile Gly 
                485                 490                 495     


Arg Met Ile Ala Glu Glu Ile Met Glu Ile His Arg Ile Arg Gly Ser 
            500                 505                 510         


Ser Pro Ser Ser Cys Gly Ser Ser Pro Leu Asn Ile Xaa Ser Xaa Pro 
        515                 520                 525             


Pro Pro Asp Ala Ser Ser Pro Gly Gly Lys Lys Ile Leu Asn Gly Gly 
    530                 535                 540                 


Xaa Pro Asp Ile Pro Ser Ser Gly Leu Leu Ser Gly Gln Ala Gln Glu 
545                 550                 555                 560 


Asn Pro Gly Tyr Pro Tyr Ser Asp Ser Ser Ser Ile Leu Gly Glu Asn 
                565                 570                 575     


Pro His Ile Gly Ile Asp Met Ile Asp Asn Asp Gln Gly Ser Ser Ser 
            580                 585                 590         


Pro Ser Asn Asp Glu Ala Ala Met Ala Val Ile Met Ser Leu Leu Glu 
        595                 600                 605             


Ala Asp Ala Gly Leu Gly Gly Pro Val Asp Phe Ser Asp Leu Pro Trp 
    610                 615                 620                 


Pro Leu 
625     


<210> 3241
<211> 60
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<400> 3241
Met Ala Asp Gln Arg Met Asp Ile Ser Ser Xaa Ile Ser Asp Phe Met 
1               5                   10                  15      


Ser Pro Gly Pro Xaa Asp Leu Leu Ser Ser Ser Leu Gly Xaa Ser Gly 
            20                  25                  30          


Val Asp Cys Asn Arg Lys Arg Lys Gly Ser Ser Xaa Asp Tyr Gln Leu 
        35                  40                  45              


Glu Tyr Xaa Glu His Gln Gly Arg Ile Lys Asn Ala 
    50                  55                  60  


<210> 3242
<211> 46
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<400> 3242
Met Ile Asn Ile Glu Ser Met Asp Xaa Asp Lys Asp Asp Pro His Gly 
1               5                   10                  15      


Arg Leu Glu Tyr Xaa Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu 
            20                  25                  30          


Ala His Ser Gln Ile Glu Lys Arg Arg Arg Asp Lys Met Asn 
        35                  40                  45      


<210> 3243
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<400> 3243
Met Ile Asn Ile Glu Ser Met Asp Xaa Asp Lys Asp Asp Pro His Gly 
1               5                   10                  15      


Arg Leu Glu Tyr Xaa Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu 
            20                  25                  30          


Ala His Ser Gln Ile Glu Lys Arg Arg Arg Asp Lys Met Asn Ser Phe 
        35                  40                  45              


Ile Asp Glu Leu Ala Ser Leu Val Pro Xaa Cys Asn Ala Met Ser Arg 
    50                  55                  60                  


Lys Leu Asp Lys Leu Xaa Val Leu 
65                  70          


<210> 3244
<211> 141
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<400> 3244
Met Ile Asn Ile Glu Ser Met Asp Xaa Asp Lys Asp Asp Pro His Gly 
1               5                   10                  15      


Arg Leu Glu Tyr Xaa Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu 
            20                  25                  30          


Ala His Ser Gln Ile Glu Lys Arg Arg Arg Asp Lys Met Asn Ser Phe 
        35                  40                  45              


Ile Asp Glu Leu Ala Ser Leu Val Pro Xaa Cys Asn Ala Met Ser Arg 
    50                  55                  60                  


Lys Leu Asp Lys Leu Xaa Val Leu Arg Met Ala Val Gln His Met Lys 
65                  70                  75                  80  


Xaa Leu Arg Gly Ala Xaa Asn Pro Tyr Xaa Glu Ala Asn Tyr Lys Pro 
                85                  90                  95      


Xaa Phe Leu Ser Asp Asp Glu Leu Lys His Leu Ile Leu Arg Ala Ala 
            100                 105                 110         


Asp Gly Phe Leu Phe Val Val Gly Cys Asp Arg Gly Lys Ile Leu Phe 
        115                 120                 125             


Val Ser Glu Ser Val Phe Lys Ile Leu Asn Tyr Ser Gln 
    130                 135                 140     


<210> 3245
<211> 583
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<400> 3245
Met Ile Asn Ile Glu Ser Met Asp Xaa Asp Lys Asp Asp Pro His Gly 
1               5                   10                  15      


Arg Leu Glu Tyr Xaa Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu 
            20                  25                  30          


Ala His Ser Gln Ile Glu Lys Arg Arg Arg Asp Lys Met Asn Ser Phe 
        35                  40                  45              


Ile Asp Glu Leu Ala Ser Leu Val Pro Xaa Cys Asn Ala Met Ser Arg 
    50                  55                  60                  


Lys Leu Asp Lys Leu Xaa Val Leu Arg Met Ala Val Gln His Met Lys 
65                  70                  75                  80  


Xaa Leu Arg Gly Ala Xaa Asn Pro Tyr Xaa Glu Ala Asn Tyr Lys Pro 
                85                  90                  95      


Xaa Phe Leu Ser Asp Asp Glu Leu Lys His Leu Ile Leu Arg Ala Ala 
            100                 105                 110         


Asp Gly Phe Leu Phe Val Val Gly Cys Asp Arg Gly Lys Ile Leu Phe 
        115                 120                 125             


Val Ser Glu Ser Val Phe Lys Ile Leu Asn Tyr Ser Gln Asn Asp Leu 
    130                 135                 140                 


Ile Gly Gln Ser Leu Phe Asp Tyr Leu His Pro Lys Asp Ile Ala Lys 
145                 150                 155                 160 


Val Lys Glu Gln Leu Ser Ser Ser Asp Xaa Ala Pro Arg Glu Arg Leu 
                165                 170                 175     


Ile Asp Ala Lys Xaa Gly Leu Pro Val Lys Xaa Asp Ile Xaa Pro Gly 
            180                 185                 190         


Pro Ser Arg Leu Cys Ser Gly Ala Arg Arg Ser Phe Phe Cys Arg Met 
        195                 200                 205             


Lys Cys Asn Arg Pro Ser Val Lys Val Glu Asp Lys Asp Phe Pro Ser 
    210                 215                 220                 


Xaa Cys Ser Lys Lys Lys Ala Asp Arg Lys Ser Phe Cys Xaa Ile His 
225                 230                 235                 240 


Ser Xaa Gly Tyr Leu Lys Ser Trp Pro Pro Xaa Lys Met Gly Leu Asp 
                245                 250                 255     


Glu Asp Asn Glu Pro Asp Asn Glu Gly Cys Asn Leu Ser Cys Leu Val 
            260                 265                 270         


Ala Ile Gly Arg Leu His Ser His Val Val Pro Gln Pro Val Asn Gly 
        275                 280                 285             


Glu Ile Arg Val Lys Ser Met Glu Tyr Val Ser Arg His Ala Ile Asp 
    290                 295                 300                 


Gly Lys Phe Val Phe Val Asp Gln Arg Ala Xaa Ala Ile Leu Ala Tyr 
305                 310                 315                 320 


Leu Pro Gln Glu Leu Leu Gly Xaa Ser Cys Tyr Glu Tyr Phe His Gln 
                325                 330                 335     


Asp Asp Ile Gly His Leu Ala Glu Cys His Arg Gln Val Leu Gln Xaa 
            340                 345                 350         


Arg Glu Lys Ile Xaa Xaa Asn Cys Tyr Lys Phe Lys Ile Lys Asp Gly 
        355                 360                 365             


Ser Phe Ile Xaa Leu Arg Ser Arg Trp Phe Ser Phe Met Asn Pro Trp 
    370                 375                 380                 


Xaa Lys Glu Val Glu Tyr Ile Val Ser Xaa Asn Xaa Val Val Leu Ala 
385                 390                 395                 400 


Asn Val Leu Glu Gly Gly Asp Pro Xaa Phe Pro Gln Leu Xaa Ala Ser 
                405                 410                 415     


Pro His Ser Met Asp Ser Met Leu Pro Ser Gly Glu Gly Gly Pro Lys 
            420                 425                 430         


Arg Xaa His Pro Xaa Val Pro Gly Ile Pro Gly Gly Xaa Arg Ala Gly 
        435                 440                 445             


Ala Gly Lys Ile Gly Arg Met Ile Ala Glu Glu Ile Met Glu Ile His 
    450                 455                 460                 


Arg Ile Arg Gly Ser Ser Pro Ser Ser Cys Gly Ser Ser Pro Leu Asn 
465                 470                 475                 480 


Ile Xaa Ser Xaa Pro Pro Pro Asp Ala Ser Ser Pro Gly Gly Lys Lys 
                485                 490                 495     


Ile Leu Asn Gly Gly Xaa Pro Asp Ile Pro Ser Ser Gly Leu Leu Ser 
            500                 505                 510         


Gly Gln Ala Gln Glu Asn Pro Gly Tyr Pro Tyr Ser Asp Ser Ser Ser 
        515                 520                 525             


Ile Leu Gly Glu Asn Pro His Ile Gly Ile Asp Met Ile Asp Asn Asp 
    530                 535                 540                 


Gln Gly Ser Ser Ser Pro Ser Asn Asp Glu Ala Ala Met Ala Val Ile 
545                 550                 555                 560 


Met Ser Leu Leu Glu Ala Asp Ala Gly Leu Gly Gly Pro Val Asp Phe 
                565                 570                 575     


Ser Asp Leu Pro Trp Pro Leu 
            580             


<210> 3246
<211> 582
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<400> 3246
Met Ile Asn Ile Glu Ser Met Asp Xaa Asp Lys Asp Asp Pro His Gly 
1               5                   10                  15      


Arg Leu Glu Tyr Xaa Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu 
            20                  25                  30          


Ala His Ser Gln Ile Glu Lys Arg Arg Arg Asp Lys Met Asn Ser Phe 
        35                  40                  45              


Ile Asp Glu Leu Ala Ser Leu Val Pro Xaa Cys Asn Ala Met Ser Arg 
    50                  55                  60                  


Lys Leu Asp Lys Leu Xaa Val Leu Arg Met Ala Val Gln His Met Lys 
65                  70                  75                  80  


Xaa Leu Arg Gly Ala Xaa Asn Pro Tyr Xaa Glu Ala Asn Tyr Lys Pro 
                85                  90                  95      


Xaa Phe Leu Ser Asp Asp Glu Leu Lys His Leu Ile Leu Arg Ala Ala 
            100                 105                 110         


Asp Gly Phe Leu Phe Val Val Gly Cys Asp Arg Gly Lys Ile Leu Phe 
        115                 120                 125             


Val Ser Glu Ser Val Phe Lys Ile Leu Asn Tyr Ser Gln Asn Asp Leu 
    130                 135                 140                 


Ile Gly Gln Ser Leu Phe Asp Tyr Leu His Pro Lys Asp Ile Ala Lys 
145                 150                 155                 160 


Val Lys Glu Gln Leu Ser Ser Ser Asp Xaa Ala Pro Arg Glu Arg Leu 
                165                 170                 175     


Ile Asp Ala Lys Xaa Gly Leu Pro Val Lys Xaa Asp Ile Xaa Pro Gly 
            180                 185                 190         


Pro Ser Arg Leu Cys Ser Gly Ala Arg Arg Ser Phe Phe Cys Arg Met 
        195                 200                 205             


Lys Cys Asn Arg Pro Ser Val Lys Val Glu Asp Lys Asp Phe Pro Ser 
    210                 215                 220                 


Xaa Cys Ser Lys Lys Lys Asp Arg Lys Ser Phe Cys Xaa Ile His Ser 
225                 230                 235                 240 


Xaa Gly Tyr Leu Lys Ser Trp Pro Pro Xaa Lys Met Gly Leu Asp Glu 
                245                 250                 255     


Asp Asn Glu Pro Asp Asn Glu Gly Cys Asn Leu Ser Cys Leu Val Ala 
            260                 265                 270         


Ile Gly Arg Leu His Ser His Val Val Pro Gln Pro Val Asn Gly Glu 
        275                 280                 285             


Ile Arg Val Lys Ser Met Glu Tyr Val Ser Arg His Ala Ile Asp Gly 
    290                 295                 300                 


Lys Phe Val Phe Val Asp Gln Arg Ala Xaa Ala Ile Leu Ala Tyr Leu 
305                 310                 315                 320 


Pro Gln Glu Leu Leu Gly Xaa Ser Cys Tyr Glu Tyr Phe His Gln Asp 
                325                 330                 335     


Asp Ile Gly His Leu Ala Glu Cys His Arg Gln Val Leu Gln Xaa Arg 
            340                 345                 350         


Glu Lys Ile Xaa Xaa Asn Cys Tyr Lys Phe Lys Ile Lys Asp Gly Ser 
        355                 360                 365             


Phe Ile Xaa Leu Arg Ser Arg Trp Phe Ser Phe Met Asn Pro Trp Xaa 
    370                 375                 380                 


Lys Glu Val Glu Tyr Ile Val Ser Xaa Asn Xaa Val Val Leu Ala Asn 
385                 390                 395                 400 


Val Leu Glu Gly Gly Asp Pro Xaa Phe Pro Gln Leu Xaa Ala Ser Pro 
                405                 410                 415     


His Ser Met Asp Ser Met Leu Pro Ser Gly Glu Gly Gly Pro Lys Arg 
            420                 425                 430         


Xaa His Pro Xaa Val Pro Gly Ile Pro Gly Gly Xaa Arg Ala Gly Ala 
        435                 440                 445             


Gly Lys Ile Gly Arg Met Ile Ala Glu Glu Ile Met Glu Ile His Arg 
    450                 455                 460                 


Ile Arg Gly Ser Ser Pro Ser Ser Cys Gly Ser Ser Pro Leu Asn Ile 
465                 470                 475                 480 


Xaa Ser Xaa Pro Pro Pro Asp Ala Ser Ser Pro Gly Gly Lys Lys Ile 
                485                 490                 495     


Leu Asn Gly Gly Xaa Pro Asp Ile Pro Ser Ser Gly Leu Leu Ser Gly 
            500                 505                 510         


Gln Ala Gln Glu Asn Pro Gly Tyr Pro Tyr Ser Asp Ser Ser Ser Ile 
        515                 520                 525             


Leu Gly Glu Asn Pro His Ile Gly Ile Asp Met Ile Asp Asn Asp Gln 
    530                 535                 540                 


Gly Ser Ser Ser Pro Ser Asn Asp Glu Ala Ala Met Ala Val Ile Met 
545                 550                 555                 560 


Ser Leu Leu Glu Ala Asp Ala Gly Leu Gly Gly Pro Val Asp Phe Ser 
                565                 570                 575     


Asp Leu Pro Trp Pro Leu 
            580         


<210> 3247
<211> 624
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<400> 3247
Met Ser Lys Glu Ala Val Ser Leu Trp Ala Leu Xaa Val Ser Leu Gln 
1               5                   10                  15      


Pro Pro Val Pro Leu Cys Val Cys Arg Glu Met Xaa Gly Ser Gly Arg 
            20                  25                  30          


Arg Lys Gln Gln Cys Val Xaa Leu Pro Phe Ile Ser Arg Glu Leu Cys 
        35                  40                  45              


Phe Tyr Leu Leu Leu Phe Pro Pro Pro Arg Leu Glu Tyr Xaa Glu His 
    50                  55                  60                  


Gln Gly Arg Ile Lys Asn Ala Arg Glu Ala His Ser Gln Ile Glu Lys 
65                  70                  75                  80  


Arg Arg Arg Asp Lys Met Asn Ser Phe Ile Asp Glu Leu Ala Ser Leu 
                85                  90                  95      


Val Pro Xaa Cys Asn Ala Met Ser Arg Lys Leu Asp Lys Leu Xaa Val 
            100                 105                 110         


Leu Arg Met Ala Val Gln His Met Lys Xaa Leu Arg Gly Ala Xaa Asn 
        115                 120                 125             


Pro Tyr Xaa Glu Ala Asn Tyr Lys Pro Xaa Phe Leu Ser Asp Asp Glu 
    130                 135                 140                 


Leu Lys His Leu Ile Leu Arg Ala Ala Asp Gly Phe Leu Phe Val Val 
145                 150                 155                 160 


Gly Cys Asp Arg Gly Lys Ile Leu Phe Val Ser Glu Ser Val Phe Lys 
                165                 170                 175     


Ile Leu Asn Tyr Ser Gln Asn Asp Leu Ile Gly Gln Ser Leu Phe Asp 
            180                 185                 190         


Tyr Leu His Pro Lys Asp Ile Ala Lys Val Lys Glu Gln Leu Ser Ser 
        195                 200                 205             


Ser Asp Xaa Ala Pro Arg Glu Arg Leu Ile Asp Ala Lys Xaa Gly Leu 
    210                 215                 220                 


Pro Val Lys Xaa Asp Ile Xaa Pro Gly Pro Ser Arg Leu Cys Ser Gly 
225                 230                 235                 240 


Ala Arg Arg Ser Phe Phe Cys Arg Met Lys Cys Asn Arg Pro Ser Val 
                245                 250                 255     


Lys Val Glu Asp Lys Asp Phe Pro Ser Xaa Cys Ser Lys Lys Lys Ala 
            260                 265                 270         


Asp Arg Lys Ser Phe Cys Xaa Ile His Ser Xaa Gly Tyr Leu Lys Ser 
        275                 280                 285             


Trp Pro Pro Xaa Lys Met Gly Leu Asp Glu Asp Asn Glu Pro Asp Asn 
    290                 295                 300                 


Glu Gly Cys Asn Leu Ser Cys Leu Val Ala Ile Gly Arg Leu His Ser 
305                 310                 315                 320 


His Val Val Pro Gln Pro Val Asn Gly Glu Ile Arg Val Lys Ser Met 
                325                 330                 335     


Glu Tyr Val Ser Arg His Ala Ile Asp Gly Lys Phe Val Phe Val Asp 
            340                 345                 350         


Gln Arg Ala Xaa Ala Ile Leu Ala Tyr Leu Pro Gln Glu Leu Leu Gly 
        355                 360                 365             


Xaa Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp Ile Gly His Leu Ala 
    370                 375                 380                 


Glu Cys His Arg Gln Val Leu Gln Xaa Arg Glu Lys Ile Xaa Xaa Asn 
385                 390                 395                 400 


Cys Tyr Lys Phe Lys Ile Lys Asp Gly Ser Phe Ile Xaa Leu Arg Ser 
                405                 410                 415     


Arg Trp Phe Ser Phe Met Asn Pro Trp Xaa Lys Glu Val Glu Tyr Ile 
            420                 425                 430         


Val Ser Xaa Asn Xaa Val Val Leu Ala Asn Val Leu Glu Gly Gly Asp 
        435                 440                 445             


Pro Xaa Phe Pro Gln Leu Xaa Ala Ser Pro His Ser Met Asp Ser Met 
    450                 455                 460                 


Leu Pro Ser Gly Glu Gly Gly Pro Lys Arg Xaa His Pro Xaa Val Pro 
465                 470                 475                 480 


Gly Ile Pro Gly Gly Xaa Arg Ala Gly Ala Gly Lys Ile Gly Arg Met 
                485                 490                 495     


Ile Ala Glu Glu Ile Met Glu Ile His Arg Ile Arg Gly Ser Ser Pro 
            500                 505                 510         


Ser Ser Cys Gly Ser Ser Pro Leu Asn Ile Xaa Ser Xaa Pro Pro Pro 
        515                 520                 525             


Asp Ala Ser Ser Pro Gly Gly Lys Lys Ile Leu Asn Gly Gly Xaa Pro 
    530                 535                 540                 


Asp Ile Pro Ser Ser Gly Leu Leu Ser Gly Gln Ala Gln Glu Asn Pro 
545                 550                 555                 560 


Gly Tyr Pro Tyr Ser Asp Ser Ser Ser Ile Leu Gly Glu Asn Pro His 
                565                 570                 575     


Ile Gly Ile Asp Met Ile Asp Asn Asp Gln Gly Ser Ser Ser Pro Ser 
            580                 585                 590         


Asn Asp Glu Ala Ala Met Ala Val Ile Met Ser Leu Leu Glu Ala Asp 
        595                 600                 605             


Ala Gly Leu Gly Gly Pro Val Asp Phe Ser Asp Leu Pro Trp Pro Leu 
    610                 615                 620                 


<210> 3248
<211> 171
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<400> 3248
Arg Ala Xaa Ala Ile Leu Ala Tyr Leu Pro Gln Glu Leu Leu Gly Xaa 
1               5                   10                  15      


Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp Ile Gly His Leu Ala Glu 
            20                  25                  30          


Cys His Arg Gln Val Leu Gln Xaa Arg Glu Lys Ile Xaa Xaa Asn Cys 
        35                  40                  45              


Tyr Lys Phe Lys Ile Lys Asp Gly Ser Phe Ile Xaa Leu Arg Ser Arg 
    50                  55                  60                  


Trp Phe Ser Phe Met Asn Pro Trp Xaa Lys Glu Val Glu Tyr Ile Val 
65                  70                  75                  80  


Ser Xaa Asn Xaa Val Val Leu Ser Arg Val Asp Xaa Gly His Leu Gly 
                85                  90                  95      


Gln Val Glu Trp Cys Xaa Val Leu Ser Arg Pro Asp Ser Arg Phe Leu 
            100                 105                 110         


Ile Ala Gly Met Phe Xaa Glu Pro Xaa Ser Trp Lys Ala Gly Xaa Gln 
        115                 120                 125             


Pro Ser His Ser Ser Gln His Pro Pro Xaa Ala Trp Xaa Ala Cys Cys 
    130                 135                 140                 


Pro Leu Glu Lys Val Ala Gln Arg Gly Pro Xaa Pro Leu Phe Gln Gly 
145                 150                 155                 160 


Phe Gln Gly Glu Pro Gly Leu Gly Gln Glu Lys 
                165                 170     


<210> 3249
<211> 540
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<400> 3249
Met Ala Ala Glu Glu Glu Ala Ala Ala Gly Gly Glu Val Ala Gly Gly 
1               5                   10                  15      


Glu Ala Xaa Ala Pro Gly Lys Val Leu Arg Glu Glu Asn Gln Cys Ile 
            20                  25                  30          


Ala Pro Val Val Ser Ser Arg Val Ser Pro Gly Xaa Arg Pro Xaa Ala 
        35                  40                  45              


Met Gly Ser Phe Ser Ser His Met Xaa Glu Phe Pro Arg Lys Arg Lys 
    50                  55                  60                  


Gly Ser Asp Ser Asp Pro Ser Gln Glu Ala His Ser Gln Xaa Glu Lys 
65                  70                  75                  80  


Arg Arg Arg Asp Lys Met Asn Asn Leu Ile Glu Glu Leu Ser Ala Met 
                85                  90                  95      


Ile Pro Gln Cys Asn Pro Met Ala Arg Lys Leu Asp Lys Leu Xaa Val 
            100                 105                 110         


Leu Arg Met Ala Val Gln His Leu Arg Ser Leu Lys Gly Leu Xaa Asn 
        115                 120                 125             


Ser Tyr Val Gly Ser Asn Tyr Arg Pro Ser Phe Leu Gln Asp Asn Glu 
    130                 135                 140                 


Leu Arg His Leu Ile Leu Lys Xaa Ala Glu Gly Phe Leu Phe Val Val 
145                 150                 155                 160 


Gly Cys Glu Arg Gly Lys Ile Leu Phe Val Ser Lys Ser Val Ser Lys 
                165                 170                 175     


Ile Leu Asn Tyr Asp Gln Ala Ser Leu Xaa Gly Gln Ser Leu Phe Asp 
            180                 185                 190         


Phe Leu His Pro Lys Asp Val Ala Lys Val Lys Glu Gln Leu Ser Ser 
        195                 200                 205             


Phe Asp Ile Ser Pro Arg Glu Lys Leu Ile Asp Ala Lys Xaa Gly Leu 
    210                 215                 220                 


Gln Val His Ser Asn Leu His Ala Gly Arg Xaa Arg Val Tyr Ser Gly 
225                 230                 235                 240 


Ser Arg Arg Ser Phe Phe Cys Arg Ile Lys Ser Cys Lys Ile Ser Val 
                245                 250                 255     


Lys Glu Glu His Gly Cys Leu Pro Asn Ser Lys Lys Lys Glu His Arg 
            260                 265                 270         


Lys Phe Tyr Xaa Ile His Cys Xaa Gly Tyr Leu Arg Ser Trp Pro Pro 
        275                 280                 285             


Asn Ile Val Gly Met Glu Glu Glu Arg Asn Ser Lys Lys Asp Asn Ser 
    290                 295                 300                 


Asn Phe Xaa Cys Leu Val Ala Ile Gly Arg Leu Gln Pro Tyr Ile Val 
305                 310                 315                 320 


Pro Gln Asn Ser Gly Glu Ile Asn Val Lys Pro Xaa Glu Phe Ile Xaa 
                325                 330                 335     


Arg Phe Ala Val Asn Gly Lys Phe Val Tyr Val Asp Gln Arg Ala Xaa 
            340                 345                 350         


Ala Ile Leu Gly Tyr Leu Pro Gln Glu Leu Leu Gly Xaa Ser Cys Tyr 
        355                 360                 365             


Glu Tyr Phe His Gln Asp Asp His Asn Asn Leu Xaa Asp Lys His Lys 
    370                 375                 380                 


Ala Val Leu Gln Ser Lys Glu Lys Ile Leu Xaa Asp Ser Tyr Lys Phe 
385                 390                 395                 400 


Arg Ala Lys Asp Gly Ser Phe Val Xaa Leu Lys Ser Gln Trp Phe Ser 
                405                 410                 415     


Phe Xaa Asn Pro Trp Xaa Lys Glu Leu Glu Tyr Ile Val Ser Val Asn 
            420                 425                 430         


Xaa Leu Val Leu Gly His Ser Glu Pro Gly Glu Ala Ser Phe Leu Pro 
        435                 440                 445             


Cys Ser Ser Gln Ser Ser Glu Glu Ser Ser Arg Gln Ser Cys Met Ser 
    450                 455                 460                 


Val Pro Gly Met Ser Xaa Gly Xaa Val Leu Gly Ala Gly Ser Ile Gly 
465                 470                 475                 480 


Xaa Asp Ile Ala Asn Glu Ile Leu Asp Leu Gln Arg Leu Gln Ser Ser 
                485                 490                 495     


Ser Tyr Leu Asp Asp Ser Ser Pro Xaa Gly Leu Met Lys Asp Xaa His 
            500                 505                 510         


Xaa Val Asn Cys Arg Ser Val Met Val His Ser Trp Ile Ser Met Pro 
        515                 520                 525             


Tyr Val Xaa Met Met Xaa Gln Pro Trp Leu His Leu 
    530                 535                 540 


<210> 3250
<211> 599
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<400> 3250
Met Ala Ala Glu Glu Glu Ala Ala Ala Gly Gly Glu Val Ala Gly Gly 
1               5                   10                  15      


Glu Ala Xaa Ala Pro Gly Lys Val Leu Arg Glu Glu Asn Gln Cys Ile 
            20                  25                  30          


Ala Pro Val Val Ser Ser Arg Val Ser Pro Gly Xaa Arg Pro Xaa Ala 
        35                  40                  45              


Met Gly Ser Phe Ser Ser His Met Xaa Glu Phe Pro Arg Lys Arg Lys 
    50                  55                  60                  


Gly Ser Asp Ser Asp Pro Ser Gln Glu Ala His Ser Gln Xaa Glu Lys 
65                  70                  75                  80  


Arg Arg Arg Asp Lys Met Asn Asn Leu Ile Glu Glu Leu Ser Ala Met 
                85                  90                  95      


Ile Pro Gln Cys Asn Pro Met Ala Arg Lys Leu Asp Lys Leu Xaa Val 
            100                 105                 110         


Leu Arg Met Ala Val Gln His Leu Arg Ser Leu Lys Gly Leu Xaa Asn 
        115                 120                 125             


Ser Tyr Val Gly Ser Asn Tyr Arg Pro Ser Phe Leu Gln Asp Asn Glu 
    130                 135                 140                 


Leu Arg His Leu Ile Leu Lys Xaa Ala Glu Gly Phe Leu Phe Val Val 
145                 150                 155                 160 


Gly Cys Glu Arg Gly Lys Ile Leu Phe Val Ser Lys Ser Val Ser Lys 
                165                 170                 175     


Ile Leu Asn Tyr Asp Gln Ala Ser Leu Xaa Gly Gln Ser Leu Phe Asp 
            180                 185                 190         


Phe Leu His Pro Lys Asp Val Ala Lys Val Lys Glu Gln Leu Ser Ser 
        195                 200                 205             


Phe Asp Ile Ser Pro Arg Glu Lys Leu Ile Asp Ala Lys Xaa Gly Leu 
    210                 215                 220                 


Gln Val His Ser Asn Leu His Ala Gly Arg Xaa Arg Val Tyr Ser Gly 
225                 230                 235                 240 


Ser Arg Arg Ser Phe Phe Cys Arg Ile Lys Ser Cys Lys Ile Ser Val 
                245                 250                 255     


Lys Glu Glu His Gly Cys Leu Pro Asn Ser Lys Lys Lys Glu His Arg 
            260                 265                 270         


Lys Phe Tyr Xaa Ile His Cys Xaa Gly Tyr Leu Arg Ser Trp Pro Pro 
        275                 280                 285             


Asn Ile Val Gly Met Glu Glu Glu Arg Asn Ser Lys Lys Asp Asn Ser 
    290                 295                 300                 


Asn Phe Xaa Cys Leu Val Ala Ile Gly Arg Leu Gln Pro Tyr Ile Val 
305                 310                 315                 320 


Pro Gln Asn Ser Gly Glu Ile Asn Val Lys Pro Xaa Glu Phe Ile Xaa 
                325                 330                 335     


Arg Phe Ala Val Asn Gly Lys Phe Val Tyr Val Asp Gln Arg Ala Xaa 
            340                 345                 350         


Ala Ile Leu Gly Tyr Leu Pro Gln Glu Leu Leu Gly Xaa Ser Cys Tyr 
        355                 360                 365             


Glu Tyr Phe His Gln Asp Asp His Asn Asn Leu Xaa Asp Lys His Lys 
    370                 375                 380                 


Ala Val Leu Gln Ser Lys Glu Lys Ile Leu Xaa Asp Ser Tyr Lys Phe 
385                 390                 395                 400 


Arg Ala Lys Asp Gly Ser Phe Val Xaa Leu Lys Ser Gln Trp Phe Ser 
                405                 410                 415     


Phe Xaa Asn Pro Trp Xaa Lys Glu Leu Glu Tyr Ile Val Ser Val Asn 
            420                 425                 430         


Xaa Leu Val Leu Gly His Ser Glu Pro Gly Glu Ala Ser Phe Leu Pro 
        435                 440                 445             


Cys Ser Ser Gln Ser Ser Glu Glu Ser Ser Arg Gln Ser Cys Met Ser 
    450                 455                 460                 


Val Pro Gly Met Ser Xaa Gly Xaa Val Leu Gly Ala Gly Ser Ile Gly 
465                 470                 475                 480 


Xaa Asp Ile Ala Asn Glu Ile Leu Asp Leu Gln Arg Leu Gln Ser Ser 
                485                 490                 495     


Ser Tyr Leu Asp Asp Ser Ser Pro Xaa Gly Leu Met Lys Asp Xaa His 
            500                 505                 510         


Xaa Val Asn Cys Arg Ser Met Ser Asn Lys Glu Leu Phe Pro Pro Ser 
        515                 520                 525             


Pro Ser Glu Met Gly Glu Leu Glu Ala Xaa Arg Gln Asn Gln Ser Xaa 
    530                 535                 540                 


Val Ala Val His Ser His Glu Pro Leu Leu Ser Asp Gly Ala Gln Leu 
545                 550                 555                 560 


Asp Phe Asp Ala Leu Cys Asp Asn Asp Asp Xaa Ala Met Ala Ala Phe 
                565                 570                 575     


Met Asn Tyr Leu Glu Ala Glu Gly Gly Leu Gly Asp Pro Gly Asp Phe 
            580                 585                 590         


Ser Asp Ile Gln Trp Xaa Leu 
        595                 


<210> 3251
<211> 588
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<400> 3251
Met Ala Ala Glu Glu Glu Ala Ala Ala Gly Gly Lys Val Leu Arg Glu 
1               5                   10                  15      


Glu Asn Gln Cys Ile Ala Pro Val Val Ser Ser Arg Val Ser Pro Gly 
            20                  25                  30          


Xaa Arg Pro Xaa Ala Met Gly Ser Phe Ser Ser His Met Xaa Glu Phe 
        35                  40                  45              


Pro Arg Lys Arg Lys Gly Ser Asp Ser Asp Pro Ser Gln Glu Ala His 
    50                  55                  60                  


Ser Gln Xaa Glu Lys Arg Arg Arg Asp Lys Met Asn Asn Leu Ile Glu 
65                  70                  75                  80  


Glu Leu Ser Ala Met Ile Pro Gln Cys Asn Pro Met Ala Arg Lys Leu 
                85                  90                  95      


Asp Lys Leu Xaa Val Leu Arg Met Ala Val Gln His Leu Arg Ser Leu 
            100                 105                 110         


Lys Gly Leu Xaa Asn Ser Tyr Val Gly Ser Asn Tyr Arg Pro Ser Phe 
        115                 120                 125             


Leu Gln Asp Asn Glu Leu Arg His Leu Ile Leu Lys Xaa Ala Glu Gly 
    130                 135                 140                 


Phe Leu Phe Val Val Gly Cys Glu Arg Gly Lys Ile Leu Phe Val Ser 
145                 150                 155                 160 


Lys Ser Val Ser Lys Ile Leu Asn Tyr Asp Gln Ala Ser Leu Xaa Gly 
                165                 170                 175     


Gln Ser Leu Phe Asp Phe Leu His Pro Lys Asp Val Ala Lys Val Lys 
            180                 185                 190         


Glu Gln Leu Ser Ser Phe Asp Ile Ser Pro Arg Glu Lys Leu Ile Asp 
        195                 200                 205             


Ala Lys Xaa Gly Leu Gln Val His Ser Asn Leu His Ala Gly Arg Xaa 
    210                 215                 220                 


Arg Val Tyr Ser Gly Ser Arg Arg Ser Phe Phe Cys Arg Ile Lys Ser 
225                 230                 235                 240 


Cys Lys Ile Ser Val Lys Glu Glu His Gly Cys Leu Pro Asn Ser Lys 
                245                 250                 255     


Lys Lys Glu His Arg Lys Phe Tyr Xaa Ile His Cys Xaa Gly Tyr Leu 
            260                 265                 270         


Arg Ser Trp Pro Pro Asn Ile Val Gly Met Glu Glu Glu Arg Asn Ser 
        275                 280                 285             


Lys Lys Asp Asn Ser Asn Phe Xaa Cys Leu Val Ala Ile Gly Arg Leu 
    290                 295                 300                 


Gln Pro Tyr Ile Val Pro Gln Asn Ser Gly Glu Ile Asn Val Lys Pro 
305                 310                 315                 320 


Xaa Glu Phe Ile Xaa Arg Phe Ala Val Asn Gly Lys Phe Val Tyr Val 
                325                 330                 335     


Asp Gln Arg Ala Xaa Ala Ile Leu Gly Tyr Leu Pro Gln Glu Leu Leu 
            340                 345                 350         


Gly Xaa Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp His Asn Asn Leu 
        355                 360                 365             


Xaa Asp Lys His Lys Ala Val Leu Gln Ser Lys Glu Lys Ile Leu Xaa 
    370                 375                 380                 


Asp Ser Tyr Lys Phe Arg Ala Lys Asp Gly Ser Phe Val Xaa Leu Lys 
385                 390                 395                 400 


Ser Gln Trp Phe Ser Phe Xaa Asn Pro Trp Xaa Lys Glu Leu Glu Tyr 
                405                 410                 415     


Ile Val Ser Val Asn Xaa Leu Val Leu Gly His Ser Glu Pro Gly Glu 
            420                 425                 430         


Ala Ser Phe Leu Pro Cys Ser Ser Gln Ser Ser Glu Glu Ser Ser Arg 
        435                 440                 445             


Gln Ser Cys Met Ser Val Pro Gly Met Ser Xaa Gly Xaa Val Leu Gly 
    450                 455                 460                 


Ala Gly Ser Ile Gly Xaa Asp Ile Ala Asn Glu Ile Leu Asp Leu Gln 
465                 470                 475                 480 


Arg Leu Gln Ser Ser Ser Tyr Leu Asp Asp Ser Ser Pro Xaa Gly Leu 
                485                 490                 495     


Met Lys Asp Xaa His Xaa Val Asn Cys Arg Ser Met Ser Asn Lys Glu 
            500                 505                 510         


Leu Phe Pro Pro Ser Pro Ser Glu Met Gly Glu Leu Glu Ala Xaa Arg 
        515                 520                 525             


Gln Asn Gln Ser Xaa Val Ala Val His Ser His Glu Pro Leu Leu Ser 
    530                 535                 540                 


Asp Gly Ala Gln Leu Asp Phe Asp Ala Leu Cys Asp Asn Asp Asp Xaa 
545                 550                 555                 560 


Ala Met Ala Ala Phe Met Asn Tyr Leu Glu Ala Glu Gly Gly Leu Gly 
                565                 570                 575     


Asp Pro Gly Asp Phe Ser Asp Ile Gln Trp Xaa Leu 
            580                 585             


<210> 3252
<211> 622
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<400> 3252
Met Ala Ala Glu Glu Glu Ala Ala Ala Gly Gly Lys Val Leu Arg Glu 
1               5                   10                  15      


Glu Asn Gln Cys Ile Ala Pro Val Val Ser Ser Arg Val Ser Pro Gly 
            20                  25                  30          


Xaa Arg Pro Xaa Ala Met Gly Ser Phe Ser Ser His Met Xaa Glu Phe 
        35                  40                  45              


Pro Arg Lys Arg Lys Gly Ser Asp Ser Asp Pro Ser Gln Ser Gly Ile 
    50                  55                  60                  


Met Xaa Glu Lys Val Val Glu Lys Leu Ser Gln Asn Pro Leu Xaa Tyr 
65                  70                  75                  80  


Leu Leu Ser Xaa Arg Ile Glu Ile Ser Ala Ser Ser Gly Ser Arg Glu 
                85                  90                  95      


Ala His Ser Gln Xaa Glu Lys Arg Arg Arg Asp Lys Met Asn Asn Leu 
            100                 105                 110         


Ile Glu Glu Leu Ser Ala Met Ile Pro Gln Cys Asn Pro Met Ala Arg 
        115                 120                 125             


Lys Leu Asp Lys Leu Xaa Val Leu Arg Met Ala Val Gln His Leu Arg 
    130                 135                 140                 


Ser Leu Lys Gly Leu Xaa Asn Ser Tyr Val Gly Ser Asn Tyr Arg Pro 
145                 150                 155                 160 


Ser Phe Leu Gln Asp Asn Glu Leu Arg His Leu Ile Leu Lys Xaa Ala 
                165                 170                 175     


Glu Gly Phe Leu Phe Val Val Gly Cys Glu Arg Gly Lys Ile Leu Phe 
            180                 185                 190         


Val Ser Lys Ser Val Ser Lys Ile Leu Asn Tyr Asp Gln Ala Ser Leu 
        195                 200                 205             


Xaa Gly Gln Ser Leu Phe Asp Phe Leu His Pro Lys Asp Val Ala Lys 
    210                 215                 220                 


Val Lys Glu Gln Leu Ser Ser Phe Asp Ile Ser Pro Arg Glu Lys Leu 
225                 230                 235                 240 


Ile Asp Ala Lys Xaa Gly Leu Gln Val His Ser Asn Leu His Ala Gly 
                245                 250                 255     


Arg Xaa Arg Val Tyr Ser Gly Ser Arg Arg Ser Phe Phe Cys Arg Ile 
            260                 265                 270         


Lys Ser Cys Lys Ile Ser Val Lys Glu Glu His Gly Cys Leu Pro Asn 
        275                 280                 285             


Ser Lys Lys Lys Glu His Arg Lys Phe Tyr Xaa Ile His Cys Xaa Gly 
    290                 295                 300                 


Tyr Leu Arg Ser Trp Pro Pro Asn Ile Val Gly Met Glu Glu Glu Arg 
305                 310                 315                 320 


Asn Ser Lys Lys Asp Asn Ser Asn Phe Xaa Cys Leu Val Ala Ile Gly 
                325                 330                 335     


Arg Leu Gln Pro Tyr Ile Val Pro Gln Asn Ser Gly Glu Ile Asn Val 
            340                 345                 350         


Lys Pro Xaa Glu Phe Ile Xaa Arg Phe Ala Val Asn Gly Lys Phe Val 
        355                 360                 365             


Tyr Val Asp Gln Arg Ala Xaa Ala Ile Leu Gly Tyr Leu Pro Gln Glu 
    370                 375                 380                 


Leu Leu Gly Xaa Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp His Asn 
385                 390                 395                 400 


Asn Leu Xaa Asp Lys His Lys Ala Val Leu Gln Ser Lys Glu Lys Ile 
                405                 410                 415     


Leu Xaa Asp Ser Tyr Lys Phe Arg Ala Lys Asp Gly Ser Phe Val Xaa 
            420                 425                 430         


Leu Lys Ser Gln Trp Phe Ser Phe Xaa Asn Pro Trp Xaa Lys Glu Leu 
        435                 440                 445             


Glu Tyr Ile Val Ser Val Asn Xaa Leu Val Leu Gly His Ser Glu Pro 
    450                 455                 460                 


Gly Glu Ala Ser Phe Leu Pro Cys Ser Ser Gln Ser Ser Glu Glu Ser 
465                 470                 475                 480 


Ser Arg Gln Ser Cys Met Ser Val Pro Gly Met Ser Xaa Gly Xaa Val 
                485                 490                 495     


Leu Gly Ala Gly Ser Ile Gly Xaa Asp Ile Ala Asn Glu Ile Leu Asp 
            500                 505                 510         


Leu Gln Arg Leu Gln Ser Ser Ser Tyr Leu Asp Asp Ser Ser Pro Xaa 
        515                 520                 525             


Gly Leu Met Lys Asp Xaa His Xaa Val Asn Cys Arg Ser Met Ser Asn 
    530                 535                 540                 


Lys Glu Leu Phe Pro Pro Ser Pro Ser Glu Met Gly Glu Leu Glu Ala 
545                 550                 555                 560 


Xaa Arg Gln Asn Gln Ser Xaa Val Ala Val His Ser His Glu Pro Leu 
                565                 570                 575     


Leu Ser Asp Gly Ala Gln Leu Asp Phe Asp Ala Leu Cys Asp Asn Asp 
            580                 585                 590         


Asp Xaa Ala Met Ala Ala Phe Met Asn Tyr Leu Glu Ala Glu Gly Gly 
        595                 600                 605             


Leu Gly Asp Pro Gly Asp Phe Ser Asp Ile Gln Trp Xaa Leu 
    610                 615                 620         


<210> 3253
<211> 636
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<400> 3253
Met Ala Ala Glu Glu Glu Ala Ala Ala Gly Gly Lys Val Leu Arg Glu 
1               5                   10                  15      


Glu Asn Gln Cys Ile Ala Pro Val Val Ser Ser Arg Val Ser Pro Gly 
            20                  25                  30          


Xaa Arg Pro Xaa Ala Met Gly Ser Phe Ser Ser His Met Xaa Glu Phe 
        35                  40                  45              


Pro Arg Lys Arg Lys Gly Ser Asp Ser Asp Pro Ser Gln Ser Gly Ile 
    50                  55                  60                  


Met Xaa Glu Lys Val Val Glu Lys Leu Ser Gln Asn Pro Leu Xaa Tyr 
65                  70                  75                  80  


Leu Leu Ser Xaa Arg Ile Glu Ile Ser Ala Ser Ser Gly Ser Arg Val 
                85                  90                  95      


Glu Asp Gly Glu His Gln Val Lys Met Lys Ala Phe Arg Glu Ala His 
            100                 105                 110         


Ser Gln Xaa Glu Lys Arg Arg Arg Asp Lys Met Asn Asn Leu Ile Glu 
        115                 120                 125             


Glu Leu Ser Ala Met Ile Pro Gln Cys Asn Pro Met Ala Arg Lys Leu 
    130                 135                 140                 


Asp Lys Leu Xaa Val Leu Arg Met Ala Val Gln His Leu Arg Ser Leu 
145                 150                 155                 160 


Lys Gly Leu Xaa Asn Ser Tyr Val Gly Ser Asn Tyr Arg Pro Ser Phe 
                165                 170                 175     


Leu Gln Asp Asn Glu Leu Arg His Leu Ile Leu Lys Xaa Ala Glu Gly 
            180                 185                 190         


Phe Leu Phe Val Val Gly Cys Glu Arg Gly Lys Ile Leu Phe Val Ser 
        195                 200                 205             


Lys Ser Val Ser Lys Ile Leu Asn Tyr Asp Gln Ala Ser Leu Xaa Gly 
    210                 215                 220                 


Gln Ser Leu Phe Asp Phe Leu His Pro Lys Asp Val Ala Lys Val Lys 
225                 230                 235                 240 


Glu Gln Leu Ser Ser Phe Asp Ile Ser Pro Arg Glu Lys Leu Ile Asp 
                245                 250                 255     


Ala Lys Xaa Gly Leu Gln Val His Ser Asn Leu His Ala Gly Arg Xaa 
            260                 265                 270         


Arg Val Tyr Ser Gly Ser Arg Arg Ser Phe Phe Cys Arg Ile Lys Ser 
        275                 280                 285             


Cys Lys Ile Ser Val Lys Glu Glu His Gly Cys Leu Pro Asn Ser Lys 
    290                 295                 300                 


Lys Lys Glu His Arg Lys Phe Tyr Xaa Ile His Cys Xaa Gly Tyr Leu 
305                 310                 315                 320 


Arg Ser Trp Pro Pro Asn Ile Val Gly Met Glu Glu Glu Arg Asn Ser 
                325                 330                 335     


Lys Lys Asp Asn Ser Asn Phe Xaa Cys Leu Val Ala Ile Gly Arg Leu 
            340                 345                 350         


Gln Pro Tyr Ile Val Pro Gln Asn Ser Gly Glu Ile Asn Val Lys Pro 
        355                 360                 365             


Xaa Glu Phe Ile Xaa Arg Phe Ala Val Asn Gly Lys Phe Val Tyr Val 
    370                 375                 380                 


Asp Gln Arg Ala Xaa Ala Ile Leu Gly Tyr Leu Pro Gln Glu Leu Leu 
385                 390                 395                 400 


Gly Xaa Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp His Asn Asn Leu 
                405                 410                 415     


Xaa Asp Lys His Lys Ala Val Leu Gln Ser Lys Glu Lys Ile Leu Xaa 
            420                 425                 430         


Asp Ser Tyr Lys Phe Arg Ala Lys Asp Gly Ser Phe Val Xaa Leu Lys 
        435                 440                 445             


Ser Gln Trp Phe Ser Phe Xaa Asn Pro Trp Xaa Lys Glu Leu Glu Tyr 
    450                 455                 460                 


Ile Val Ser Val Asn Xaa Leu Val Leu Gly His Ser Glu Pro Gly Glu 
465                 470                 475                 480 


Ala Ser Phe Leu Pro Cys Ser Ser Gln Ser Ser Glu Glu Ser Ser Arg 
                485                 490                 495     


Gln Ser Cys Met Ser Val Pro Gly Met Ser Xaa Gly Xaa Val Leu Gly 
            500                 505                 510         


Ala Gly Ser Ile Gly Xaa Asp Ile Ala Asn Glu Ile Leu Asp Leu Gln 
        515                 520                 525             


Arg Leu Gln Ser Ser Ser Tyr Leu Asp Asp Ser Ser Pro Xaa Gly Leu 
    530                 535                 540                 


Met Lys Asp Xaa His Xaa Val Asn Cys Arg Ser Met Ser Asn Lys Glu 
545                 550                 555                 560 


Leu Phe Pro Pro Ser Pro Ser Glu Met Gly Glu Leu Glu Ala Xaa Arg 
                565                 570                 575     


Gln Asn Gln Ser Xaa Val Ala Val His Ser His Glu Pro Leu Leu Ser 
            580                 585                 590         


Asp Gly Ala Gln Leu Asp Phe Asp Ala Leu Cys Asp Asn Asp Asp Xaa 
        595                 600                 605             


Ala Met Ala Ala Phe Met Asn Tyr Leu Glu Ala Glu Gly Gly Leu Gly 
    610                 615                 620                 


Asp Pro Gly Asp Phe Ser Asp Ile Gln Trp Xaa Leu 
625                 630                 635     


<210> 3254
<211> 602
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<400> 3254
Met Ala Ala Glu Glu Glu Ala Ala Ala Gly Gly Lys Val Leu Arg Glu 
1               5                   10                  15      


Glu Asn Gln Cys Ile Ala Pro Val Val Ser Ser Arg Val Ser Pro Gly 
            20                  25                  30          


Xaa Arg Pro Xaa Ala Met Gly Ser Phe Ser Ser His Met Xaa Glu Phe 
        35                  40                  45              


Pro Arg Lys Arg Lys Gly Ser Asp Ser Asp Pro Ser Gln Val Glu Asp 
    50                  55                  60                  


Gly Glu His Gln Val Lys Met Lys Ala Phe Arg Glu Ala His Ser Gln 
65                  70                  75                  80  


Xaa Glu Lys Arg Arg Arg Asp Lys Met Asn Asn Leu Ile Glu Glu Leu 
                85                  90                  95      


Ser Ala Met Ile Pro Gln Cys Asn Pro Met Ala Arg Lys Leu Asp Lys 
            100                 105                 110         


Leu Xaa Val Leu Arg Met Ala Val Gln His Leu Arg Ser Leu Lys Gly 
        115                 120                 125             


Leu Xaa Asn Ser Tyr Val Gly Ser Asn Tyr Arg Pro Ser Phe Leu Gln 
    130                 135                 140                 


Asp Asn Glu Leu Arg His Leu Ile Leu Lys Xaa Ala Glu Gly Phe Leu 
145                 150                 155                 160 


Phe Val Val Gly Cys Glu Arg Gly Lys Ile Leu Phe Val Ser Lys Ser 
                165                 170                 175     


Val Ser Lys Ile Leu Asn Tyr Asp Gln Ala Ser Leu Xaa Gly Gln Ser 
            180                 185                 190         


Leu Phe Asp Phe Leu His Pro Lys Asp Val Ala Lys Val Lys Glu Gln 
        195                 200                 205             


Leu Ser Ser Phe Asp Ile Ser Pro Arg Glu Lys Leu Ile Asp Ala Lys 
    210                 215                 220                 


Xaa Gly Leu Gln Val His Ser Asn Leu His Ala Gly Arg Xaa Arg Val 
225                 230                 235                 240 


Tyr Ser Gly Ser Arg Arg Ser Phe Phe Cys Arg Ile Lys Ser Cys Lys 
                245                 250                 255     


Ile Ser Val Lys Glu Glu His Gly Cys Leu Pro Asn Ser Lys Lys Lys 
            260                 265                 270         


Glu His Arg Lys Phe Tyr Xaa Ile His Cys Xaa Gly Tyr Leu Arg Ser 
        275                 280                 285             


Trp Pro Pro Asn Ile Val Gly Met Glu Glu Glu Arg Asn Ser Lys Lys 
    290                 295                 300                 


Asp Asn Ser Asn Phe Xaa Cys Leu Val Ala Ile Gly Arg Leu Gln Pro 
305                 310                 315                 320 


Tyr Ile Val Pro Gln Asn Ser Gly Glu Ile Asn Val Lys Pro Xaa Glu 
                325                 330                 335     


Phe Ile Xaa Arg Phe Ala Val Asn Gly Lys Phe Val Tyr Val Asp Gln 
            340                 345                 350         


Arg Ala Xaa Ala Ile Leu Gly Tyr Leu Pro Gln Glu Leu Leu Gly Xaa 
        355                 360                 365             


Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp His Asn Asn Leu Xaa Asp 
    370                 375                 380                 


Lys His Lys Ala Val Leu Gln Ser Lys Glu Lys Ile Leu Xaa Asp Ser 
385                 390                 395                 400 


Tyr Lys Phe Arg Ala Lys Asp Gly Ser Phe Val Xaa Leu Lys Ser Gln 
                405                 410                 415     


Trp Phe Ser Phe Xaa Asn Pro Trp Xaa Lys Glu Leu Glu Tyr Ile Val 
            420                 425                 430         


Ser Val Asn Xaa Leu Val Leu Gly His Ser Glu Pro Gly Glu Ala Ser 
        435                 440                 445             


Phe Leu Pro Cys Ser Ser Gln Ser Ser Glu Glu Ser Ser Arg Gln Ser 
    450                 455                 460                 


Cys Met Ser Val Pro Gly Met Ser Xaa Gly Xaa Val Leu Gly Ala Gly 
465                 470                 475                 480 


Ser Ile Gly Xaa Asp Ile Ala Asn Glu Ile Leu Asp Leu Gln Arg Leu 
                485                 490                 495     


Gln Ser Ser Ser Tyr Leu Asp Asp Ser Ser Pro Xaa Gly Leu Met Lys 
            500                 505                 510         


Asp Xaa His Xaa Val Asn Cys Arg Ser Met Ser Asn Lys Glu Leu Phe 
        515                 520                 525             


Pro Pro Ser Pro Ser Glu Met Gly Glu Leu Glu Ala Xaa Arg Gln Asn 
    530                 535                 540                 


Gln Ser Xaa Val Ala Val His Ser His Glu Pro Leu Leu Ser Asp Gly 
545                 550                 555                 560 


Ala Gln Leu Asp Phe Asp Ala Leu Cys Asp Asn Asp Asp Xaa Ala Met 
                565                 570                 575     


Ala Ala Phe Met Asn Tyr Leu Glu Ala Glu Gly Gly Leu Gly Asp Pro 
            580                 585                 590         


Gly Asp Phe Ser Asp Ile Gln Trp Xaa Leu 
        595                 600         


<210> 3255
<211> 551
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<400> 3255
Met Gly Ser Phe Ser Ser His Met Xaa Glu Phe Pro Arg Lys Arg Lys 
1               5                   10                  15      


Gly Ser Asp Ser Asp Pro Ser Gln Glu Ala His Ser Gln Xaa Glu Lys 
            20                  25                  30          


Arg Arg Arg Asp Lys Met Asn Asn Leu Ile Glu Glu Leu Ser Ala Met 
        35                  40                  45              


Ile Pro Gln Cys Asn Pro Met Ala Arg Lys Leu Asp Lys Leu Xaa Val 
    50                  55                  60                  


Leu Arg Met Ala Val Gln His Leu Arg Ser Leu Lys Gly Leu Xaa Asn 
65                  70                  75                  80  


Ser Tyr Val Gly Ser Asn Tyr Arg Pro Ser Phe Leu Gln Asp Asn Glu 
                85                  90                  95      


Leu Arg His Leu Ile Leu Lys Xaa Ala Glu Gly Phe Leu Phe Val Val 
            100                 105                 110         


Gly Cys Glu Arg Gly Lys Ile Leu Phe Val Ser Lys Ser Val Ser Lys 
        115                 120                 125             


Ile Leu Asn Tyr Asp Gln Ala Ser Leu Xaa Gly Gln Ser Leu Phe Asp 
    130                 135                 140                 


Phe Leu His Pro Lys Asp Val Ala Lys Val Lys Glu Gln Leu Ser Ser 
145                 150                 155                 160 


Phe Asp Ile Ser Pro Arg Glu Lys Leu Ile Asp Ala Lys Xaa Gly Leu 
                165                 170                 175     


Gln Val His Ser Asn Leu His Ala Gly Arg Xaa Arg Val Tyr Ser Gly 
            180                 185                 190         


Ser Arg Arg Ser Phe Phe Cys Arg Ile Lys Ser Cys Lys Ile Ser Val 
        195                 200                 205             


Lys Glu Glu His Gly Cys Leu Pro Asn Ser Lys Lys Lys Glu His Arg 
    210                 215                 220                 


Lys Phe Tyr Xaa Ile His Cys Xaa Gly Tyr Leu Arg Ser Trp Pro Pro 
225                 230                 235                 240 


Asn Ile Val Gly Met Glu Glu Glu Arg Asn Ser Lys Lys Asp Asn Ser 
                245                 250                 255     


Asn Phe Xaa Cys Leu Val Ala Ile Gly Arg Leu Gln Pro Tyr Ile Val 
            260                 265                 270         


Pro Gln Asn Ser Gly Glu Ile Asn Val Lys Pro Xaa Glu Phe Ile Xaa 
        275                 280                 285             


Arg Phe Ala Val Asn Gly Lys Phe Val Tyr Val Asp Gln Arg Ala Xaa 
    290                 295                 300                 


Ala Ile Leu Gly Tyr Leu Pro Gln Glu Leu Leu Gly Xaa Ser Cys Tyr 
305                 310                 315                 320 


Glu Tyr Phe His Gln Asp Asp His Asn Asn Leu Xaa Asp Lys His Lys 
                325                 330                 335     


Ala Val Leu Gln Ser Lys Glu Lys Ile Leu Xaa Asp Ser Tyr Lys Phe 
            340                 345                 350         


Arg Ala Lys Asp Gly Ser Phe Val Xaa Leu Lys Ser Gln Trp Phe Ser 
        355                 360                 365             


Phe Xaa Asn Pro Trp Xaa Lys Glu Leu Glu Tyr Ile Val Ser Val Asn 
    370                 375                 380                 


Xaa Leu Val Leu Gly His Ser Glu Pro Gly Glu Ala Ser Phe Leu Pro 
385                 390                 395                 400 


Cys Ser Ser Gln Ser Ser Glu Glu Ser Ser Arg Gln Ser Cys Met Ser 
                405                 410                 415     


Val Pro Gly Met Ser Xaa Gly Xaa Val Leu Gly Ala Gly Ser Ile Gly 
            420                 425                 430         


Xaa Asp Ile Ala Asn Glu Ile Leu Asp Leu Gln Arg Leu Gln Ser Ser 
        435                 440                 445             


Ser Tyr Leu Asp Asp Ser Ser Pro Xaa Gly Leu Met Lys Asp Xaa His 
    450                 455                 460                 


Xaa Val Asn Cys Arg Ser Met Ser Asn Lys Glu Leu Phe Pro Pro Ser 
465                 470                 475                 480 


Pro Ser Glu Met Gly Glu Leu Glu Ala Xaa Arg Gln Asn Gln Ser Xaa 
                485                 490                 495     


Val Ala Val His Ser His Glu Pro Leu Leu Ser Asp Gly Ala Gln Leu 
            500                 505                 510         


Asp Phe Asp Ala Leu Cys Asp Asn Asp Asp Xaa Ala Met Ala Ala Phe 
        515                 520                 525             


Met Asn Tyr Leu Glu Ala Glu Gly Gly Leu Gly Asp Pro Gly Asp Phe 
    530                 535                 540                 


Ser Asp Ile Gln Trp Xaa Leu 
545                 550     


<210> 3256
<211> 588
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<400> 3256
Xaa Pro Val Val Ser Ser Arg Val Ser Pro Gly Xaa Arg Pro Xaa Ala 
1               5                   10                  15      


Met Gly Ser Phe Ser Ser His Met Xaa Glu Phe Pro Arg Lys Arg Lys 
            20                  25                  30          


Gly Ser Asp Ser Asp Pro Ser His Gln Asn Pro Leu Xaa Tyr Leu Leu 
        35                  40                  45              


Ser Xaa Arg Ile Glu Ile Ser Ala Ser Ser Gly Ser Arg Glu Ala His 
    50                  55                  60                  


Ser Gln Xaa Glu Lys Arg Arg Arg Asp Lys Met Asn Asn Leu Ile Glu 
65                  70                  75                  80  


Glu Leu Ser Ala Met Ile Pro Gln Cys Asn Pro Met Ala Arg Lys Leu 
                85                  90                  95      


Asp Lys Leu Xaa Val Leu Arg Met Ala Val Gln His Leu Arg Ser Leu 
            100                 105                 110         


Lys Gly Leu Xaa Asn Ser Tyr Val Gly Ser Asn Tyr Arg Pro Ser Phe 
        115                 120                 125             


Leu Gln Asp Asn Glu Leu Arg His Leu Ile Leu Lys Xaa Ala Glu Gly 
    130                 135                 140                 


Phe Leu Phe Val Val Gly Cys Glu Arg Gly Lys Ile Leu Phe Val Ser 
145                 150                 155                 160 


Lys Ser Val Ser Lys Ile Leu Asn Tyr Asp Gln Ala Ser Leu Xaa Gly 
                165                 170                 175     


Gln Ser Leu Phe Asp Phe Leu His Pro Lys Asp Val Ala Lys Val Lys 
            180                 185                 190         


Glu Gln Leu Ser Ser Phe Asp Ile Ser Pro Arg Glu Lys Leu Ile Asp 
        195                 200                 205             


Ala Lys Xaa Gly Leu Gln Val His Ser Asn Leu His Ala Gly Arg Xaa 
    210                 215                 220                 


Arg Val Tyr Ser Gly Ser Arg Arg Ser Phe Phe Cys Arg Ile Lys Ser 
225                 230                 235                 240 


Cys Lys Ile Ser Val Lys Glu Glu His Gly Cys Leu Pro Asn Ser Lys 
                245                 250                 255     


Lys Lys Glu His Arg Lys Phe Tyr Xaa Ile His Cys Xaa Gly Tyr Leu 
            260                 265                 270         


Arg Ser Trp Pro Pro Asn Ile Val Gly Met Glu Glu Glu Arg Asn Ser 
        275                 280                 285             


Lys Lys Asp Asn Ser Asn Phe Xaa Cys Leu Val Ala Ile Gly Arg Leu 
    290                 295                 300                 


Gln Pro Tyr Ile Val Pro Gln Asn Ser Gly Glu Ile Asn Val Lys Pro 
305                 310                 315                 320 


Xaa Glu Phe Ile Xaa Arg Phe Ala Val Asn Gly Lys Phe Val Tyr Val 
                325                 330                 335     


Asp Gln Arg Ala Xaa Ala Ile Leu Gly Tyr Leu Pro Gln Glu Leu Leu 
            340                 345                 350         


Gly Xaa Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp His Asn Asn Leu 
        355                 360                 365             


Xaa Asp Lys His Lys Ala Val Leu Gln Ser Lys Glu Lys Ile Leu Xaa 
    370                 375                 380                 


Asp Ser Tyr Lys Phe Arg Ala Lys Asp Gly Ser Phe Val Xaa Leu Lys 
385                 390                 395                 400 


Ser Gln Trp Phe Ser Phe Xaa Asn Pro Trp Xaa Lys Glu Leu Glu Tyr 
                405                 410                 415     


Ile Val Ser Val Asn Xaa Leu Val Leu Gly His Ser Glu Pro Gly Glu 
            420                 425                 430         


Ala Ser Phe Leu Pro Cys Ser Ser Gln Ser Ser Glu Glu Ser Ser Arg 
        435                 440                 445             


Gln Ser Cys Met Ser Val Pro Gly Met Ser Xaa Gly Xaa Val Leu Gly 
    450                 455                 460                 


Ala Gly Ser Ile Gly Xaa Asp Ile Ala Asn Glu Ile Leu Asp Leu Gln 
465                 470                 475                 480 


Arg Leu Gln Ser Ser Ser Tyr Leu Asp Asp Ser Ser Pro Xaa Gly Leu 
                485                 490                 495     


Met Lys Asp Xaa His Xaa Val Asn Cys Arg Ser Met Ser Asn Lys Glu 
            500                 505                 510         


Leu Phe Pro Pro Ser Pro Ser Glu Met Gly Glu Leu Glu Ala Xaa Arg 
        515                 520                 525             


Gln Asn Gln Ser Xaa Val Ala Val His Ser His Glu Pro Leu Leu Ser 
    530                 535                 540                 


Asp Gly Ala Gln Leu Asp Phe Asp Ala Leu Cys Asp Asn Asp Asp Xaa 
545                 550                 555                 560 


Ala Met Ala Ala Phe Met Asn Tyr Leu Glu Ala Glu Gly Gly Leu Gly 
                565                 570                 575     


Asp Pro Gly Asp Phe Ser Asp Ile Gln Trp Xaa Leu 
            580                 585             


<210> 3257
<211> 279
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<400> 3257
Met Ser Leu His Gln Phe Leu Leu Glu Pro Ile Xaa Cys His Ala Trp 
1               5                   10                  15      


Asn Arg Asp Arg Xaa Gln Ile Ala Leu Ser Pro Asn Asn His Glu Val 
            20                  25                  30          


His Ile Tyr Lys Lys Asn Gly Ser Gln Trp Val Lys Ala His Glu Leu 
        35                  40                  45              


Lys Glu His Asn Gly His Ile Xaa Gly Ile Asp Trp Ala Pro Lys Ser 
    50                  55                  60                  


Asp Arg Ile Val Xaa Cys Gly Ala Asp Arg Asn Ala Tyr Val Trp Ser 
65                  70                  75                  80  


Gln Lys Asp Gly Val Trp Lys Pro Xaa Leu Val Ile Leu Arg Ile Asn 
                85                  90                  95      


Arg Ala Ala Xaa Phe Val Lys Trp Ser Pro Leu Glu Asn Lys Phe Ala 
            100                 105                 110         


Val Gly Ser Gly Ala Arg Leu Ile Ser Val Cys Tyr Phe Glu Ser Glu 
        115                 120                 125             


Asn Asp Trp Trp Val Ser Lys His Ile Lys Lys Pro Ile Arg Ser Xaa 
    130                 135                 140                 


Val Leu Ser Leu Asp Trp His Pro Asn Asn Val Leu Leu Ala Ala Gly 
145                 150                 155                 160 


Ser Cys Asp Phe Lys Cys Arg Val Phe Ser Ala Tyr Ile Lys Glu Val 
                165                 170                 175     


Asp Glu Lys Pro Ala Ser Xaa Pro Trp Gly Ser Lys Met Pro Phe Gly 
            180                 185                 190         


Gln Leu Met Ser Glu Phe Gly Gly Ser Gly Xaa Gly Gly Trp Val His 
        195                 200                 205             


Gly Val Ser Phe Ser Ala Ser Gly Ser Arg Leu Ala Trp Val Ser His 
    210                 215                 220                 


Asp Ser Xaa Val Ser Val Ala Asp Ala Ser Lys Ser Val Gln Val Ser 
225                 230                 235                 240 


Xaa Leu Lys Xaa Glu Phe Leu Pro Leu Leu Ser Val Ser Phe Val Ser 
                245                 250                 255     


Glu Asn Ser Ser Cys Phe Arg Ala Met Xaa Ala Ala Gln Cys Ser Leu 
            260                 265                 270         


Xaa Xaa Met Xaa Ala Ala Ala 
        275                 


<210> 3258
<211> 370
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<400> 3258
Met Ser Leu His Gln Phe Leu Leu Glu Pro Ile Xaa Cys His Ala Trp 
1               5                   10                  15      


Asn Arg Asp Arg Xaa Gln Ile Ala Leu Ser Pro Asn Asn His Glu Val 
            20                  25                  30          


His Ile Tyr Lys Lys Asn Gly Ser Gln Trp Val Lys Ala His Glu Leu 
        35                  40                  45              


Lys Glu His Asn Gly His Ile Xaa Gly Ile Asp Trp Ala Pro Lys Ser 
    50                  55                  60                  


Asp Arg Ile Val Xaa Cys Gly Ala Asp Arg Asn Ala Tyr Val Trp Ser 
65                  70                  75                  80  


Gln Lys Asp Gly Val Trp Lys Pro Xaa Leu Val Ile Leu Arg Ile Asn 
                85                  90                  95      


Arg Ala Ala Xaa Phe Val Lys Trp Ser Pro Leu Glu Asn Lys Phe Ala 
            100                 105                 110         


Val Gly Ser Gly Ala Arg Leu Ile Ser Val Cys Tyr Phe Glu Ser Glu 
        115                 120                 125             


Asn Asp Trp Trp Val Ser Lys His Ile Lys Lys Pro Ile Arg Ser Xaa 
    130                 135                 140                 


Val Leu Ser Leu Asp Trp His Pro Asn Asn Val Leu Leu Ala Ala Gly 
145                 150                 155                 160 


Ser Cys Asp Phe Lys Cys Arg Val Phe Ser Ala Tyr Ile Lys Glu Val 
                165                 170                 175     


Asp Glu Lys Pro Ala Ser Xaa Pro Trp Gly Ser Lys Met Pro Phe Gly 
            180                 185                 190         


Gln Leu Met Ser Glu Phe Gly Gly Ser Gly Xaa Gly Gly Trp Val His 
        195                 200                 205             


Gly Val Ser Phe Ser Ala Ser Gly Ser Arg Leu Ala Trp Val Ser His 
    210                 215                 220                 


Asp Ser Xaa Val Ser Val Ala Asp Ala Ser Lys Ser Val Gln Val Ser 
225                 230                 235                 240 


Xaa Leu Lys Xaa Glu Phe Leu Pro Leu Leu Ser Val Ser Phe Val Ser 
                245                 250                 255     


Glu Asn Ser Val Val Ala Ala Gly His Asp Cys Cys Pro Met Leu Phe 
            260                 265                 270         


Asn Tyr Asp Asp Arg Gly Cys Leu Xaa Phe Val Ser Lys Leu Asp Ile 
        275                 280                 285             


Pro Lys Gln Ser Ile Gln Arg Asn Met Ser Ala Met Glu Arg Phe Arg 
    290                 295                 300                 


Asn Met Asp Lys Arg Ala Xaa Xaa Glu Asp Arg Asn Xaa Ala Leu Glu 
305                 310                 315                 320 


Xaa Leu His Gln Asn Ser Ile Xaa Gln Val Ser Ile Tyr Glu Val Asp 
                325                 330                 335     


Lys Gln Asp Cys Arg Lys Phe Cys Xaa Xaa Gly Ile Asp Gly Ala Met 
            340                 345                 350         


Xaa Ile Trp Asp Phe Lys Xaa Leu Glu Ser Ser Ile Gln Gly Leu Arg 
        355                 360                 365             


Ile Met 
    370 


<210> 3259
<211> 53
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<400> 3259
Met Ser Leu His Gln Phe Leu Leu Glu Pro Ile Xaa Cys His Ala Trp 
1               5                   10                  15      


Asn Arg Asp Arg Xaa Arg Pro Val Cys Leu Asp Tyr Tyr Ser Leu Val 
            20                  25                  30          


Arg Leu Pro Ser Val Pro Ile Ile Xaa Lys Cys Xaa Ser Ile Arg Arg 
        35                  40                  45              


Xaa Gly Ala Ser Gly 
    50              


<210> 3260
<211> 21
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<400> 3260
Met Ala Tyr His Ser Phe Leu Val Glu Pro Ile Ser Cys His Ala Trp 
1               5                   10                  15      


Asn Lys Asp Arg Xaa 
            20      


<210> 3261
<211> 83
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 3261
Met Ala Tyr His Ser Phe Leu Val Glu Pro Ile Ser Cys His Ala Trp 
1               5                   10                  15      


Asn Lys Asp Arg Xaa Gln Ile Ala Ile Cys Pro Asn Asn His Glu Val 
            20                  25                  30          


His Ile Tyr Glu Lys Ser Gly Ala Lys Trp Xaa Lys Val His Glu Leu 
        35                  40                  45              


Lys Glu His Asn Gly Gln Val Xaa Gly Ile Asp Trp Ala Pro Glu Ser 
    50                  55                  60                  


Asn Arg Ile Val Xaa Cys Gly Xaa Asp Arg Asn Ala Tyr Val Trp Xaa 
65                  70                  75                  80  


Leu Lys Gly 
            


<210> 3262
<211> 102
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 3262
Met Ala Tyr His Ser Phe Leu Val Glu Pro Ile Ser Cys His Ala Trp 
1               5                   10                  15      


Asn Lys Asp Arg Xaa Gln Ile Ala Ile Cys Pro Asn Asn His Glu Val 
            20                  25                  30          


His Ile Tyr Glu Lys Ser Gly Ala Lys Trp Xaa Lys Val His Glu Leu 
        35                  40                  45              


Lys Glu His Asn Gly Gln Val Xaa Gly Ile Asp Trp Ala Pro Glu Ser 
    50                  55                  60                  


Asn Arg Ile Val Xaa Cys Gly Xaa Asp Arg Asn Ala Tyr Val Trp Xaa 
65                  70                  75                  80  


Leu Lys Gly Arg Xaa Trp Lys Pro Xaa Leu Val Ile Leu Arg Ile Asn 
                85                  90                  95      


Arg Ala Ala Arg Cys Val 
            100         


<210> 3263
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 3263
Met Ala Tyr His Ser Phe Leu Val Glu Pro Ile Ser Cys His Ala Trp 
1               5                   10                  15      


Asn Lys Asp Arg Xaa Gln Ile Ala Ile Cys Pro Asn Asn His Glu Val 
            20                  25                  30          


His Ile Tyr Glu Lys Ser Gly Ala Lys Trp Xaa Lys Val His Glu Leu 
        35                  40                  45              


Lys Glu His Asn Gly Gln Val Xaa Gly Ile Asp Trp Ala Pro Glu Ser 
    50                  55                  60                  


Asn Arg Ile Val Xaa Cys Gly Xaa Asp Arg Asn Ala Tyr Val Trp Xaa 
65                  70                  75                  80  


Leu Lys Gly Arg Xaa Trp Lys Pro Xaa Leu Val Ile Leu Arg Ile Asn 
                85                  90                  95      


Arg Ala Ala Arg Cys Val Arg Trp Ala Pro Asn Glu 
            100                 105             


<210> 3264
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 3264
Met Ala Tyr His Ser Phe Leu Val Glu Pro Ile Ser Cys His Ala Trp 
1               5                   10                  15      


Asn Lys Asp Arg Xaa Gln Ile Ala Ile Cys Pro Asn Asn His Glu Val 
            20                  25                  30          


His Ile Tyr Glu Lys Ser Gly Ala Lys Trp Xaa Lys Val His Glu Leu 
        35                  40                  45              


Lys Glu His Asn Gly Gln Val Xaa Gly Ile Asp Trp Ala Pro Glu Ser 
    50                  55                  60                  


Asn Arg Ile Val Xaa Cys Gly Xaa Asp Arg Asn Ala Tyr Val Trp Xaa 
65                  70                  75                  80  


Leu Lys Gly Arg Xaa Trp Lys Pro Xaa Leu Val Ile Leu Arg Ile Asn 
                85                  90                  95      


Arg Ala Ala Arg Cys Val Arg Trp Ala Pro Asn Glu Asn Lys Phe Ala 
            100                 105                 110         


Val Gly Ser Gly Ser Arg Val Ile Ser Ile Cys Tyr Phe Glu Gln Glu 
        115                 120                 125             


<210> 3265
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 3265
Met Ala Tyr His Ser Phe Leu Val Glu Pro Ile Ser Cys His Ala Trp 
1               5                   10                  15      


Asn Lys Asp Arg Xaa Gln Ile Ala Ile Cys Pro Asn Asn His Glu Val 
            20                  25                  30          


His Ile Tyr Glu Lys Ser Gly Ala Lys Trp Xaa Lys Val His Glu Leu 
        35                  40                  45              


Lys Glu His Asn Gly Gln Val Xaa Gly Ile Asp Trp Ala Pro Glu Ser 
    50                  55                  60                  


Asn Arg Ile Val Xaa Cys Gly Xaa Asp Arg Asn Ala Tyr Val Trp Xaa 
65                  70                  75                  80  


Leu Lys Gly Arg Xaa Trp Lys Pro Xaa Leu Val Ile Leu Arg Ile Asn 
                85                  90                  95      


Arg Ala Ala Arg Cys Val Arg Trp Ala Pro Asn Glu Asn Lys Phe Ala 
            100                 105                 110         


Val Gly Ser Gly Ser Arg Val Ile Ser Ile Cys Tyr Phe Glu Gln Glu 
        115                 120                 125             


Asn Asp 
    130 


<210> 3266
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 3266
Met Ala Tyr His Ser Phe Leu Val Glu Pro Ile Ser Cys His Ala Trp 
1               5                   10                  15      


Asn Lys Asp Arg Xaa Gln Ile Ala Ile Cys Pro Asn Asn His Glu Val 
            20                  25                  30          


His Ile Tyr Glu Lys Ser Gly Ala Lys Trp Xaa Lys Val His Glu Leu 
        35                  40                  45              


Lys Glu His Asn Gly Gln Val Xaa Gly Ile Asp Trp Ala Pro Glu Ser 
    50                  55                  60                  


Asn Arg Ile Val Xaa Cys Gly Xaa Asp Arg Asn Ala Tyr Val Trp Xaa 
65                  70                  75                  80  


Leu Lys Gly Arg Xaa Trp Lys Pro Xaa Leu Val Ile Leu Arg Ile Asn 
                85                  90                  95      


Arg Ala Ala Arg Cys Val Arg Trp Ala Pro Asn Glu Asn Lys Phe Ala 
            100                 105                 110         


Val Gly Ser Gly Ser Arg Val Ile Ser Ile Cys Tyr Phe Glu Gln Glu 
        115                 120                 125             


Asn Asp Trp Trp Val 
    130             


<210> 3267
<211> 372
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(348)
<223> Selenocysteine

<400> 3267
Met Ala Tyr His Ser Phe Leu Val Glu Pro Ile Ser Cys His Ala Trp 
1               5                   10                  15      


Asn Lys Asp Arg Xaa Gln Ile Ala Ile Cys Pro Asn Asn His Glu Val 
            20                  25                  30          


His Ile Tyr Glu Lys Ser Gly Ala Lys Trp Xaa Lys Val His Glu Leu 
        35                  40                  45              


Lys Glu His Asn Gly Gln Val Xaa Gly Ile Asp Trp Ala Pro Glu Ser 
    50                  55                  60                  


Asn Arg Ile Val Xaa Cys Gly Xaa Asp Arg Asn Ala Tyr Val Trp Xaa 
65                  70                  75                  80  


Leu Lys Gly Arg Xaa Trp Lys Pro Xaa Leu Val Ile Leu Arg Ile Asn 
                85                  90                  95      


Arg Ala Ala Arg Cys Val Arg Trp Ala Pro Asn Glu Asn Lys Phe Ala 
            100                 105                 110         


Val Gly Ser Gly Ser Arg Val Ile Ser Ile Cys Tyr Phe Glu Gln Glu 
        115                 120                 125             


Asn Asp Trp Trp Val Cys Lys His Ile Lys Lys Pro Ile Arg Ser Xaa 
    130                 135                 140                 


Val Leu Ser Leu Asp Trp His Pro Asn Asn Val Leu Leu Ala Ala Gly 
145                 150                 155                 160 


Ser Cys Asp Phe Lys Cys Arg Ile Phe Ser Ala Tyr Ile Lys Glu Val 
                165                 170                 175     


Glu Glu Arg Pro Ala Pro Xaa Pro Trp Gly Ser Lys Met Pro Phe Gly 
            180                 185                 190         


Glu Leu Met Phe Glu Ser Ser Ser Ser Cys Gly Trp Val His Gly Val 
        195                 200                 205             


Cys Phe Ser Ala Ser Gly Ser Arg Val Ala Trp Val Ser His Asp Ser 
    210                 215                 220                 


Xaa Val Cys Leu Ala Asp Ala Asp Lys Lys Met Ala Val Ala Xaa Leu 
225                 230                 235                 240 


Ala Ser Glu Xaa Leu Pro Leu Leu Ala Leu Xaa Phe Ile Xaa Asp Asn 
                245                 250                 255     


Ser Leu Val Ala Ala Gly His Asp Cys Phe Pro Val Leu Phe Xaa Tyr 
            260                 265                 270         


Asp Ala Ala Ala Gly Met Leu Ser Phe Gly Gly Arg Leu Asp Val Pro 
        275                 280                 285             


Lys Gln Ser Ser Gln Arg Gly Leu Xaa Ala Arg Glu Arg Phe Gln Asn 
    290                 295                 300                 


Leu Asp Lys Lys Ala Ser Ser Glu Gly Gly Xaa Ala Ala Gly Ala Gly 
305                 310                 315                 320 


Leu Asp Ser Leu His Lys Asn Ser Val Ser Gln Ile Ser Val Leu Ser 
                325                 330                 335     


Gly Gly Lys Ala Lys Cys Ser Gln Phe Cys Xaa Xaa Gly Met Asp Gly 
            340                 345                 350         


Gly Met Ser Ile Trp Asp Val Lys Ser Leu Glu Ser Ala Leu Lys Asp 
        355                 360                 365             


Leu Lys Ile Lys 
    370         


<210> 3268
<211> 32
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<400> 3268
Met Ala Tyr His Ser Phe Leu Val Glu Pro Ile Ser Cys His Ala Trp 
1               5                   10                  15      


Asn Lys Asp Arg Xaa Arg Gln Pro Val Pro Gly Glu Asp Arg Val Ala 
            20                  25                  30          


<210> 3269
<211> 165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<400> 3269
Lys Glu Gly Arg Arg Ala Ser His Xaa Ala Pro Gln Val Leu Phe Ser 
1               5                   10                  15      


His Arg Glu Pro Pro Leu Glu Leu Lys Asp Xaa Asp Ala Ala Val Gly 
            20                  25                  30          


Asp Asn Ile Gly Tyr Ile Xaa Phe Val Leu Phe Pro Arg His Xaa Asn 
        35                  40                  45              


Ala Ser Ala Arg Asp Asn Xaa Ile Asn Leu Ile His Xaa Phe Arg Asp 
    50                  55                  60                  


Tyr Leu His Tyr His Ile Lys Cys Ser Lys Ala Tyr Ile His Xaa Arg 
65                  70                  75                  80  


Met Arg Ala Lys Xaa Ser Asp Phe Leu Lys Val Leu Asn Arg Ala Arg 
                85                  90                  95      


Pro Asp Ala Glu Lys Lys Glu Met Lys Xaa Ile Xaa Phe Ser Leu Ala 
            100                 105                 110         


Glu Leu Gly Pro Arg Lys Glu Lys Gln Glu Xaa Asn Ser Cys Ile His 
        115                 120                 125             


Pro Glu Asn Gln Ile Met Leu Leu Met Gly Glu Asp Val Phe Ile Pro 
    130                 135                 140                 


Leu Ile Leu Gly Ile Arg Gly Gly Ser Gly Trp Gln Leu Lys Ala Gly 
145                 150                 155                 160 


Xaa Leu Ala Xaa Gly 
                165 


<210> 3270
<211> 90
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 3270
Met Ile Leu Leu Glu Val Asn Asn Arg Ile Ile Glu Glu Xaa Leu Ala 
1               5                   10                  15      


Leu Lys Phe Glu Asn Ala Ala Ala Gly Asn Lys Pro Glu Ala Val Glu 
            20                  25                  30          


Val Xaa Phe Ala Asp Phe Asp Gly Val Leu Tyr His Ile Ser Asn Pro 
        35                  40                  45              


Asn Gly Asp Lys Xaa Lys Val Met Val Ser Ile Ser Leu Lys Phe Tyr 
    50                  55                  60                  


Lys Glu Leu Gln Ala His Gly Ala Asp Glu Leu Leu Lys Arg Val Tyr 
65                  70                  75                  80  


Gly Ser Phe Leu Val Asn Pro Glu Ser Gly 
                85                  90  


<210> 3271
<211> 300
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<400> 3271
Met Ile Leu Leu Glu Val Asn Asn Arg Ile Ile Glu Glu Xaa Leu Ala 
1               5                   10                  15      


Leu Lys Phe Glu Asn Ala Ala Ala Gly Asn Lys Pro Glu Ala Val Glu 
            20                  25                  30          


Val Xaa Phe Ala Asp Phe Asp Gly Val Leu Tyr His Ile Ser Asn Pro 
        35                  40                  45              


Asn Gly Asp Lys Xaa Lys Val Met Val Ser Ile Ser Leu Lys Phe Tyr 
    50                  55                  60                  


Lys Glu Leu Gln Ala His Gly Ala Asp Glu Leu Leu Lys Arg Val Tyr 
65                  70                  75                  80  


Gly Ser Phe Leu Val Asn Pro Glu Ser Gly Tyr Asn Val Ser Leu Leu 
                85                  90                  95      


Tyr Asp Leu Glu Asn Leu Pro Ala Ser Lys Asp Ser Ile Val His Gln 
            100                 105                 110         


Ala Gly Met Leu Lys Arg Asn Cys Phe Ala Ser Val Phe Glu Lys Tyr 
        115                 120                 125             


Phe Gln Phe Gln Glu Glu Gly Lys Glu Gly Glu Asn Arg Ala Val Ile 
    130                 135                 140                 


His Tyr Arg Asp Asp Glu Xaa Met Tyr Val Glu Ser Lys Lys Asp Arg 
145                 150                 155                 160 


Val Xaa Val Val Phe Ser Xaa Val Phe Lys Asp Asp Asp Asp Val Val 
                165                 170                 175     


Ile Gly Lys Val Phe Met Gln Glu Phe Lys Glu Gly Arg Arg Ala Ser 
            180                 185                 190         


His Xaa Ala Pro Gln Val Leu Phe Ser His Arg Glu Pro Pro Leu Glu 
        195                 200                 205             


Leu Lys Asp Xaa Asp Ala Ala Val Gly Asp Asn Ile Gly Tyr Ile Xaa 
    210                 215                 220                 


Phe Val Leu Phe Pro Arg His Xaa Asn Ala Ser Ala Arg Asp Asn Xaa 
225                 230                 235                 240 


Ile Asn Leu Ile His Xaa Phe Arg Asp Tyr Leu His Tyr His Ile Lys 
                245                 250                 255     


Cys Ser Lys Ala Tyr Ile His Xaa Arg Met Arg Ala Lys Xaa Ser Asp 
            260                 265                 270         


Phe Leu Lys Val Leu Asn Arg Ala Arg Pro Asp Ala Glu Lys Lys Glu 
        275                 280                 285             


Met Lys Xaa Ile Xaa Gly Lys Xaa Phe Ser Ser Arg 
    290                 295                 300 


<210> 3272
<211> 91
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 3272
Met Ile Leu Leu Glu Val Asn Asn Arg Ile Ile Glu Glu Xaa Leu Ala 
1               5                   10                  15      


Leu Lys Phe Glu Asn Ala Ala Ala Gly Asn Lys Pro Glu Ala Val Glu 
            20                  25                  30          


Val Xaa Phe Ala Asp Phe Asp Gly Val Leu Tyr His Ile Ser Asn Pro 
        35                  40                  45              


Asn Gly Asp Lys Xaa Lys Val Met Val Ser Ile Ser Leu Lys Phe Tyr 
    50                  55                  60                  


Lys Glu Leu Gln Ala His Gly Ala Asp Glu Leu Leu Lys Arg Val Tyr 
65                  70                  75                  80  


Gly Ser Phe Leu Val Asn Pro Glu Ser Val Phe 
                85                  90      


<210> 3273
<211> 38
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<400> 3273
Met Ile Leu Leu Glu Val Asn Asn Arg Ile Ile Glu Glu Xaa Leu Ala 
1               5                   10                  15      


Leu Lys Phe Glu Asn Ala Ala Ala Gly Asn Lys Pro Glu Ala Val Glu 
            20                  25                  30          


Val Xaa Phe Ala Gly Glu 
        35              


<210> 3274
<211> 84
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 3274
Met Asp Pro Asp Xaa Lys Leu Ile Gly Asn Met Ala Leu Leu Pro Ile 
1               5                   10                  15      


Arg Ser Gln Phe Lys Gly Pro Ala Pro Arg Glu Xaa Lys Asp Xaa Asp 
            20                  25                  30          


Ile Val Asp Glu Ala Ile Tyr Tyr Phe Lys Ala Asn Val Phe Phe Lys 
        35                  40                  45              


Asn Tyr Glu Ile Lys Asn Glu Ala Asp Arg Xaa Leu Ile Tyr Ile Xaa 
    50                  55                  60                  


Leu Tyr Ile Ser Glu Cys Leu Lys Lys Leu Gln Lys Cys Asn Ser Lys 
65                  70                  75                  80  


Ser Gln Gly Glu 
                


<210> 3275
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<400> 3275
Met Pro Ala Tyr His Ser Ser Leu Met Asp Pro Asp Xaa Lys Leu Ile 
1               5                   10                  15      


Gly Asn Met Ala Leu Leu Pro Ile Arg Ser Gln Phe Lys Gly Pro Ala 
            20                  25                  30          


Pro Arg Glu Xaa Lys Asp Xaa Asp Ile Val Asp Glu Ala Ile Tyr Tyr 
        35                  40                  45              


Phe Lys Ala Asn Val Phe Phe Lys Asn Tyr Glu Ile Lys Asn Glu Ala 
    50                  55                  60                  


Asp Arg Xaa Leu Ile Tyr Ile Xaa Leu Tyr Ile Ser Glu Cys Leu Lys 
65                  70                  75                  80  


Lys Leu Gln Lys Cys Asn Ser Lys Ser Gln Glu Val Met Arg Ala Tyr 
                85                  90                  95      


Leu Gln Gln 
            


<210> 3276
<211> 178
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<400> 3276
Met Pro Ala Tyr His Ser Ser Leu Met Asp Pro Asp Xaa Lys Leu Ile 
1               5                   10                  15      


Gly Asn Met Ala Leu Leu Pro Ile Arg Ser Gln Phe Lys Gly Pro Ala 
            20                  25                  30          


Pro Arg Glu Xaa Lys Asp Xaa Asp Ile Val Asp Glu Ala Ile Tyr Tyr 
        35                  40                  45              


Phe Lys Ala Asn Val Phe Phe Lys Asn Tyr Glu Ile Lys Asn Glu Ala 
    50                  55                  60                  


Asp Arg Xaa Leu Ile Tyr Ile Xaa Leu Tyr Ile Ser Glu Cys Leu Lys 
65                  70                  75                  80  


Lys Leu Gln Lys Cys Asn Ser Lys Ser Gln Gly Glu Lys Glu Met Tyr 
                85                  90                  95      


Xaa Leu Gly Ile Xaa Asn Phe Pro Ile Pro Gly Glu Pro Gly Phe Pro 
            100                 105                 110         


Leu Asn Ala Ile Tyr Ala Lys Pro Ala Asn Lys Gln Glu Asp Glu Val 
        115                 120                 125             


Met Arg Ala Tyr Leu Gln Gln Leu Arg Gln Glu Xaa Gly Leu Arg Leu 
    130                 135                 140                 


Cys Glu Lys Val Phe Asp Pro Gln Asn Asp Lys Pro Ser Lys Trp Trp 
145                 150                 155                 160 


Xaa Cys Phe Val Lys Arg Gln Phe Met Asn Lys Ser Leu Ser Gly Pro 
                165                 170                 175     


Gly Gln 
        


<210> 3277
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<400> 3277
Met Arg Phe Met Met Met Arg Ala Glu Asn Phe Phe Ile Leu Arg Arg 
1               5                   10                  15      


Lys Pro Val Glu Gly Tyr Asp Ile Ser Phe Leu Ile Xaa Asn Phe His 
            20                  25                  30          


Xaa Glu Gln Met Tyr Lys His Lys Leu Val Asp Phe Val Ile His Phe 
        35                  40                  45              


Met Glu Glu Ile Asp Lys Glu Ile Ser Glu Met Lys Leu Ser Val Asn 
    50                  55                  60                  


Ala Arg Ala Arg Ile Val Ala Glu Glu Phe Leu Lys Asn 
65                  70                  75          


<210> 3278
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<400> 3278
Met Arg Phe Met Met Met Arg Ala Glu Asn Phe Phe Ile Leu Arg Arg 
1               5                   10                  15      


Lys Pro Val Glu Gly Tyr Asp Ile Ser Phe Leu Ile Xaa Asn Phe His 
            20                  25                  30          


Xaa Glu Gln Met Tyr Lys His Lys Leu Val Asp Phe Val Ile His Phe 
        35                  40                  45              


Met Glu Glu Ile Asp Lys Glu Ile Ser Glu Met Lys Leu Ser Val Asn 
    50                  55                  60                  


Ala Arg Ala Arg Ile Val Ala Glu Glu Phe Leu Lys Asn Phe 
65                  70                  75              


<210> 3279
<211> 168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<400> 3279
Met Xaa Ala Xaa Leu Arg Pro Tyr Leu Ser Ala Val Arg Ala Xaa Leu 
1               5                   10                  15      


Gln Ala Ala Leu Cys Leu Glu Asn Phe Ser Ser Gln Val Val Glu Arg 
            20                  25                  30          


His Asn Lys Pro Glu Val Glu Val Arg Ser Ser Lys Glu Leu Leu Leu 
        35                  40                  45              


Gln Pro Val Xaa Ile Ser Arg Asn Glu Lys Glu Lys Val Leu Ile Glu 
    50                  55                  60                  


Gly Ser Ile Asn Ser Val Arg Val Ser Ile Ala Val Lys Gln Ala Asp 
65                  70                  75                  80  


Glu Ile Glu Lys Ile Leu Cys His Lys Phe Met Arg Phe Met Met Met 
                85                  90                  95      


Arg Ala Glu Asn Phe Phe Ile Leu Arg Arg Lys Pro Val Glu Gly Tyr 
            100                 105                 110         


Asp Ile Ser Phe Leu Ile Xaa Asn Phe His Xaa Glu Gln Met Tyr Lys 
        115                 120                 125             


His Lys Leu Val Asp Phe Val Ile His Phe Met Glu Glu Ile Asp Lys 
    130                 135                 140                 


Glu Ile Ser Glu Met Lys Leu Ser Val Asn Ala Arg Ala Arg Ile Val 
145                 150                 155                 160 


Ala Glu Glu Phe Leu Lys Asn Phe 
                165             


<210> 3280
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 3280
Met Xaa Ala Xaa Leu Arg Pro Tyr Leu Ser Ala Val Arg Ala Xaa Leu 
1               5                   10                  15      


Gln Ala Ala Leu Cys Leu Glu Asn Phe Ser Ser Gln Val Val Glu Arg 
            20                  25                  30          


His Asn Lys Pro Glu Val Glu Val Arg Ser Ser Lys Glu Leu Leu Leu 
        35                  40                  45              


Gln Pro Val Xaa Ile Ser Arg Asn Glu Lys Glu Lys Val Leu Ile Glu 
    50                  55                  60                  


Gly Ser Ile Asn Ser Val Arg Val Ser Ile Ala Val Lys Gln Ala Asp 
65                  70                  75                  80  


Glu Ile Glu Lys Ile Leu Cys His Lys Phe Met Arg Phe Met Met Met 
                85                  90                  95      


Arg Ala Glu Asn Phe Phe Ile Leu Arg Arg Lys Pro Val Glu Ile Ile 
            100                 105                 110         


Leu 
    


<210> 3281
<211> 44
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<400> 3281
Met Xaa Ala Xaa Leu Arg Pro Tyr Leu Ser Ala Val Arg Ala Xaa Leu 
1               5                   10                  15      


Gln Ala Ala Leu Cys Leu Glu Asn Phe Ser Ser Gln Val Val Glu Arg 
            20                  25                  30          


His Asn Lys Pro Glu Val Glu Val Ser Pro Arg Gln 
        35                  40                  


<210> 3282
<211> 187
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<400> 3282
Met Val Arg Glu Pro Gly Pro Arg Pro Gly Xaa Pro Gly Cys Ser Ala 
1               5                   10                  15      


Ser Gly Gln Trp Xaa Ala Xaa Leu Arg Pro Tyr Leu Ser Ala Val Arg 
            20                  25                  30          


Ala Xaa Leu Gln Ala Ala Leu Cys Leu Glu Asn Phe Ser Ser Gln Val 
        35                  40                  45              


Val Glu Arg His Asn Lys Pro Glu Val Glu Val Arg Ser Ser Lys Glu 
    50                  55                  60                  


Leu Leu Leu Gln Pro Val Xaa Ile Ser Arg Asn Glu Lys Glu Lys Val 
65                  70                  75                  80  


Leu Ile Glu Gly Ser Ile Asn Ser Val Arg Val Ser Ile Ala Val Lys 
                85                  90                  95      


Gln Ala Asp Glu Ile Glu Lys Ile Leu Cys His Lys Phe Met Arg Phe 
            100                 105                 110         


Met Met Met Arg Ala Glu Asn Phe Phe Ile Leu Arg Arg Lys Pro Val 
        115                 120                 125             


Glu Gly Tyr Asp Ile Ser Phe Leu Ile Xaa Asn Phe His Xaa Glu Gln 
    130                 135                 140                 


Met Tyr Lys His Lys Leu Val Asp Phe Val Ile His Phe Met Glu Glu 
145                 150                 155                 160 


Ile Asp Lys Glu Ile Ser Glu Met Lys Leu Ser Val Asn Ala Arg Ala 
                165                 170                 175     


Arg Ile Val Ala Glu Glu Phe Leu Lys Asn Phe 
            180                 185         


<210> 3283
<211> 154
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<400> 3283
Met Ser Lys Asn Xaa Val Ser Ser Ala Arg Phe Arg Lys Val Asp Val 
1               5                   10                  15      


Asp Glu Tyr Asp Glu Asn Lys Phe Val Asp Glu Glu Asp Gly Gly Asp 
            20                  25                  30          


Gly Gln Ala Gly Pro Asp Glu Gly Glu Val Asp Ser Cys Leu Arg His 
        35                  40                  45              


Ser Ile Xaa Gly Asn Met Xaa Ala Ala Leu Gln Ala Ala Leu Lys Asn 
    50                  55                  60                  


Pro Pro Ile Asn Xaa Lys Ser Gln Ala Val Lys Asp Arg Ala Gly Ser 
65                  70                  75                  80  


Ile Val Leu Lys Val Leu Ile Ser Phe Lys Ala Asn Asp Ile Glu Lys 
                85                  90                  95      


Ala Val Gln Ser Leu Asp Lys Asn Gly Val Asp Leu Leu Met Lys Tyr 
            100                 105                 110         


Ile Tyr Lys Gly Phe Glu Ser Pro Ser Asp Asn Ser Ser Ala Met Leu 
        115                 120                 125             


Leu Gln Trp His Glu Lys Ala Leu Ala Ala Gly Gly Val Gly Ser Ile 
    130                 135                 140                 


Val Arg Val Leu Xaa Ala Arg Lys Xaa Val 
145                 150                 


<210> 3284
<211> 151
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 3284
Met Ser Lys Asn Xaa Val Ser Ser Ala Arg Phe Arg Lys Val Asp Val 
1               5                   10                  15      


Asp Glu Tyr Asp Glu Asn Lys Phe Val Asp Glu Glu Asp Gly Gly Asp 
            20                  25                  30          


Gly Gln Ala Gly Pro Asp Glu Gly Glu Val Asp Ser Cys Leu Arg Gln 
        35                  40                  45              


Gly Asn Met Xaa Ala Ala Leu Gln Ala Ala Leu Lys Asn Pro Pro Ile 
    50                  55                  60                  


Asn Xaa Lys Ser Gln Ala Val Lys Asp Arg Ala Gly Ser Ile Val Leu 
65                  70                  75                  80  


Lys Val Leu Ile Ser Phe Lys Ala Asn Asp Ile Glu Lys Ala Val Gln 
                85                  90                  95      


Ser Leu Asp Lys Asn Gly Val Asp Leu Leu Met Lys Tyr Ile Tyr Lys 
            100                 105                 110         


Gly Phe Glu Ser Pro Ser Asp Asn Ser Ser Ala Met Leu Leu Gln Trp 
        115                 120                 125             


His Glu Lys Ala Leu Ala Ala Gly Gly Val Gly Ser Ile Val Arg Val 
    130                 135                 140                 


Leu Xaa Ala Arg Lys Xaa Val 
145                 150     


<210> 3285
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 3285
Met Ser Lys Asn Xaa Val Ser Ser Ala Arg Phe Arg Lys Val Asp Val 
1               5                   10                  15      


Asp Glu Tyr Asp Glu Asn Lys Phe Val Asp Glu Glu Asp Gly Gly Asp 
            20                  25                  30          


Gly Gln Ala Gly Pro Asp Glu Gly Glu Val Asp Ser Cys Leu Arg Gln 
        35                  40                  45              


Gly Asn Met Xaa Ala Ala Leu Gln Ala Ala Leu Lys Asn Pro Pro Ile 
    50                  55                  60                  


Asn Xaa Lys Ser Gln Ala Val Lys Asp Arg Ala Gly Ser Ile Val Leu 
65                  70                  75                  80  


Lys Val Leu Ile Ser Phe Lys Ala Asn Asp Ile Glu Lys Ala Val Gln 
                85                  90                  95      


Ser Leu Asp Lys Asn Gly Val Asp Leu Leu Met Lys Tyr Ile Tyr Lys 
            100                 105                 110         


Gly Phe Glu Ser Pro Ser Asp Asn Ser Ser Ala Met Leu Leu Gln Trp 
        115                 120                 125             


His Glu Lys Val Pro Leu Val 
    130                 135 


<210> 3286
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<400> 3286
Met Glu Asp Lys Val Xaa Ser Pro Glu Lys Ala Glu Glu Ala Lys Leu 
1               5                   10                  15      


Lys Ala Arg Tyr Pro His Leu Gly Gln Lys Pro Gly Gly Ser Asp Phe 
            20                  25                  30          


Leu Arg Lys Arg Leu Gln Lys Gly Gln Lys Tyr Phe Asp Ser Gly Asp 
        35                  40                  45              


Tyr Asn Met Ala Lys Ala Lys Met Lys Asn Lys Gln Leu Pro Xaa Ala 
    50                  55                  60                  


Ala Pro Asp Lys Xaa Glu Val Xaa 
65                  70          


<210> 3287
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 3287
Met Glu Asp Lys Val Xaa Ser Pro Glu Lys Ala Glu Glu Ala Lys Leu 
1               5                   10                  15      


Lys Ala Arg Tyr Pro His Leu Gly Gln Lys Pro Gly Gly Ser Asp Phe 
            20                  25                  30          


Leu Arg Lys Arg Leu Gln Lys Gly Gln Lys Tyr Phe Asp Ser Gly Asp 
        35                  40                  45              


Tyr Asn Met Ala Lys Ala Lys Met Lys Asn Lys Gln Leu Pro Xaa Ala 
    50                  55                  60                  


Ala Pro Asp Lys Xaa Glu Val Xaa Gly Asp His Ile Pro Xaa Pro Gln 
65                  70                  75                  80  


Asp Leu Pro Gln Arg Lys Pro Ser Leu Val Ala Ser Lys Leu Ala Gly 
                85                  90                  95      


<210> 3288
<211> 112
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<400> 3288
Met Ser Ala Glu Val Pro Glu Ala Ala Ser Ala Glu Glu Gln Lys Glu 
1               5                   10                  15      


Met Glu Asp Lys Val Xaa Ser Pro Glu Lys Ala Glu Glu Ala Lys Leu 
            20                  25                  30          


Lys Ala Arg Tyr Pro His Leu Gly Gln Lys Pro Gly Gly Ser Asp Phe 
        35                  40                  45              


Leu Arg Lys Arg Leu Gln Lys Gly Gln Lys Tyr Phe Asp Ser Gly Asp 
    50                  55                  60                  


Tyr Asn Met Ala Lys Ala Lys Met Lys Asn Lys Gln Leu Pro Xaa Ala 
65                  70                  75                  80  


Ala Pro Asp Lys Xaa Glu Val Xaa Gly Asp His Ile Pro Xaa Pro Gln 
                85                  90                  95      


Asp Leu Pro Gln Arg Lys Pro Ser Leu Val Ala Ser Lys Leu Ala Gly 
            100                 105                 110         


<210> 3289
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 3289
Met Ser Ala Glu Val Pro Glu Ala Ala Ser Ala Glu Glu Gln Lys Gln 
1               5                   10                  15      


Lys Tyr Phe Asp Ser Gly Asp Tyr Asn Met Ala Lys Ala Lys Met Lys 
            20                  25                  30          


Asn Lys Gln Leu Pro Xaa Ala Ala Pro Asp Lys Xaa Glu Val Xaa Gly 
        35                  40                  45              


Asp His Ile Pro Xaa Pro Gln Asp Leu Pro Gln Arg Lys Pro Ser Leu 
    50                  55                  60                  


Val Ala Ser Lys Leu Ala Gly 
65                  70      


<210> 3290
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<400> 3290
Met Ser Ala Glu Val Pro Glu Ala Ala Ser Ala Glu Glu Gln Lys Ser 
1               5                   10                  15      


Glu His Asn Met Leu Pro Trp Ser Leu Gln Pro Ser Ile Pro Asn Ser 
            20                  25                  30          


Leu Glu Glu Met Glu Asp Lys Val Xaa Ser Pro Glu Lys Ala Glu Glu 
        35                  40                  45              


Ala Lys Leu Lys Ala Arg Tyr Pro His Leu Gly Gln Lys Pro Gly Gly 
    50                  55                  60                  


Ser Asp Phe Leu Arg Lys Arg Leu Gln Lys Gly Gln Lys Tyr Phe Asp 
65                  70                  75                  80  


Ser Gly Asp Tyr Asn Met Ala Lys Ala Lys Met Lys Asn Lys Gln Leu 
                85                  90                  95      


Pro Xaa Ala Ala Pro Asp Lys Xaa Glu Val Xaa Gly Asp His Ile Pro 
            100                 105                 110         


Xaa Pro Gln Asp Leu Pro Gln Arg Lys Pro Ser Leu Val Ala Ser Lys 
        115                 120                 125             


Leu Ala Gly 
    130     


<210> 3291
<211> 97
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<400> 3291
Met Leu Xaa Cys Ala Phe Arg Tyr Gly Arg Asp Asp Leu Glu Val Ile 
1               5                   10                  15      


Gly Leu Xaa Phe Arg Lys Asp Leu Tyr Val Gln Xaa Leu Gln Val Val 
            20                  25                  30          


Pro Ala Glu Ser Ser Ser Pro Gln Gly Pro Leu Xaa Val Leu Gln Glu 
        35                  40                  45              


Arg Leu Leu His Lys Leu Gly Asp Asn Ala Tyr Pro Phe Xaa Leu Gln 
    50                  55                  60                  


Met Val Xaa Asn Leu Pro Cys Ser Val Xaa Leu Gln Pro Gly Pro Glu 
65                  70                  75                  80  


Asp Ala Gly Lys Pro Cys Gly Ile Asp Phe Glu Val Lys Ser Phe Cys 
                85                  90                  95      


Ala 
    


<210> 3292
<211> 359
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<400> 3292
Met Ser Lys Val Phe Lys Lys Xaa Ser Ser Asn Gly Lys Leu Ser Ile 
1               5                   10                  15      


Tyr Leu Gly Lys Arg Asp Phe Val Asp His Val Asp Xaa Val Glu Pro 
            20                  25                  30          


Ile Asp Gly Val Val Leu Val Asp Pro Glu Tyr Leu Lys Cys Arg Lys 
        35                  40                  45              


Leu Phe Val Met Leu Xaa Cys Ala Phe Arg Tyr Gly Arg Asp Asp Leu 
    50                  55                  60                  


Glu Val Ile Gly Leu Xaa Phe Arg Lys Asp Leu Tyr Val Gln Xaa Leu 
65                  70                  75                  80  


Gln Val Val Pro Ala Glu Ser Ser Ser Pro Gln Gly Pro Leu Xaa Val 
                85                  90                  95      


Leu Gln Glu Arg Leu Leu His Lys Leu Gly Asp Asn Ala Tyr Pro Phe 
            100                 105                 110         


Xaa Leu Gln Met Val Xaa Asn Leu Pro Cys Ser Val Xaa Leu Gln Pro 
        115                 120                 125             


Gly Pro Glu Asp Ala Gly Lys Pro Cys Gly Ile Asp Phe Glu Val Lys 
    130                 135                 140                 


Ser Phe Cys Ala Glu Asn Pro Glu Glu Xaa Val Ser Lys Arg Asp Tyr 
145                 150                 155                 160 


Val Arg Leu Val Val Arg Lys Val Gln Phe Ala Pro Pro Glu Ala Gly 
                165                 170                 175     


Pro Gly Pro Ser Ala Gln Xaa Ile Arg Arg Phe Leu Leu Ser Ala Gln 
            180                 185                 190         


Pro Leu Gln Leu Gln Ala Trp Met Asp Arg Glu Val His Tyr His Gly 
        195                 200                 205             


Glu Pro Ile Ser Val Asn Val Ser Ile Asn Asn Cys Xaa Asn Lys Val 
    210                 215                 220                 


Ile Lys Lys Ile Lys Ile Ser Val Asp Gln Ile Xaa Asp Val Val Leu 
225                 230                 235                 240 


Tyr Ser Leu Asp Lys Tyr Xaa Lys Xaa Val Phe Ile Gln Glu Phe Xaa 
                245                 250                 255     


Glu Xaa Val Ala Ala Asn Ser Ser Phe Ser Gln Ser Phe Ala Val Xaa 
            260                 265                 270         


Pro Ile Leu Ala Ala Ser Cys Gln Lys Arg Gly Leu Ala Leu Asp Gly 
        275                 280                 285             


Lys Leu Lys His Glu Asp Xaa Asn Leu Ala Ser Ser Xaa Ile Ile Arg 
    290                 295                 300                 


Pro Gly Met Asp Lys Glu Leu Leu Gly Ile Leu Val Ser Tyr Lys Val 
305                 310                 315                 320 


Arg Val Asn Leu Met Val Ser Cys Gly Gly Ile Leu Gly Asp Leu Xaa 
                325                 330                 335     


Ala Ser Asp Val Gly Val Glu Leu Pro Leu Val Leu Ile His Pro Lys 
            340                 345                 350         


Pro Ser His Glu Ala Ala Arg 
        355                 


<210> 3293
<211> 388
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<400> 3293
Met Ser Lys Val Phe Lys Lys Xaa Ser Ser Asn Gly Lys Leu Ser Ile 
1               5                   10                  15      


Tyr Leu Gly Lys Arg Asp Phe Val Asp His Val Asp Xaa Val Glu Pro 
            20                  25                  30          


Ile Asp Gly Val Val Leu Val Asp Pro Glu Tyr Leu Lys Cys Arg Lys 
        35                  40                  45              


Leu Phe Val Met Leu Xaa Cys Ala Phe Arg Tyr Gly Arg Asp Asp Leu 
    50                  55                  60                  


Glu Val Ile Gly Leu Xaa Phe Arg Lys Asp Leu Tyr Val Gln Xaa Leu 
65                  70                  75                  80  


Gln Val Val Pro Ala Glu Ser Ser Ser Pro Gln Gly Pro Leu Xaa Val 
                85                  90                  95      


Leu Gln Glu Arg Leu Leu His Lys Leu Gly Asp Asn Ala Tyr Pro Phe 
            100                 105                 110         


Xaa Leu Gln Met Val Xaa Asn Leu Pro Cys Ser Val Xaa Leu Gln Pro 
        115                 120                 125             


Gly Pro Glu Asp Ala Gly Lys Pro Cys Gly Ile Asp Phe Glu Val Lys 
    130                 135                 140                 


Ser Phe Cys Ala Glu Asn Pro Glu Glu Xaa Val Ser Lys Arg Asp Tyr 
145                 150                 155                 160 


Val Arg Leu Val Val Arg Lys Val Gln Phe Ala Pro Pro Glu Ala Gly 
                165                 170                 175     


Pro Gly Pro Ser Ala Gln Xaa Ile Arg Arg Phe Leu Leu Ser Ala Gln 
            180                 185                 190         


Pro Leu Gln Leu Gln Ala Trp Met Asp Arg Glu Val His Tyr His Gly 
        195                 200                 205             


Glu Pro Ile Ser Val Asn Val Ser Ile Asn Asn Cys Xaa Asn Lys Val 
    210                 215                 220                 


Ile Lys Lys Ile Lys Ile Ser Val Asp Gln Ile Xaa Asp Val Val Leu 
225                 230                 235                 240 


Tyr Ser Leu Asp Lys Tyr Xaa Lys Xaa Val Phe Ile Gln Glu Phe Xaa 
                245                 250                 255     


Glu Xaa Val Ala Ala Asn Ser Ser Phe Ser Gln Ser Phe Ala Val Xaa 
            260                 265                 270         


Pro Ile Leu Ala Ala Ser Cys Gln Lys Arg Gly Leu Ala Leu Asp Gly 
        275                 280                 285             


Lys Leu Lys His Glu Asp Xaa Asn Leu Ala Ser Ser Xaa Ile Ile Arg 
    290                 295                 300                 


Pro Gly Met Asp Lys Glu Leu Leu Gly Ile Leu Val Ser Tyr Lys Val 
305                 310                 315                 320 


Arg Val Asn Leu Met Val Ser Cys Gly Gly Ile Leu Gly Asp Leu Xaa 
                325                 330                 335     


Ala Ser Asp Val Gly Val Glu Leu Pro Leu Val Leu Ile His Pro Lys 
            340                 345                 350         


Pro Ser His Glu Ala Ala Ser Ser Glu Asp Ile Val Ile Glu Glu Phe 
        355                 360                 365             


Xaa Arg Lys Gly Glu Glu Glu Ser Gln Lys Ala Val Glu Ala Glu Gly 
    370                 375                 380                 


Asp Glu Gly Ser 
385             


<210> 3294
<211> 388
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<400> 3294
Met Ser Lys Val Phe Lys Lys Xaa Ser Ser Asn Gly Lys Leu Ser Ile 
1               5                   10                  15      


Tyr Leu Gly Lys Arg Asp Phe Val Asp His Val Asp Xaa Val Glu Pro 
            20                  25                  30          


Ile Asp Gly Val Val Leu Val Asp Pro Glu Tyr Leu Lys Cys Arg Lys 
        35                  40                  45              


Leu Phe Val Met Leu Xaa Cys Ala Phe Arg Tyr Gly Arg Asp Asp Leu 
    50                  55                  60                  


Glu Val Ile Gly Leu Xaa Phe Arg Lys Asp Leu Tyr Val Gln Xaa Leu 
65                  70                  75                  80  


Gln Val Val Pro Ala Glu Ser Ser Ser Pro Gln Gly Pro Leu Xaa Val 
                85                  90                  95      


Leu Gln Glu Arg Leu Leu His Lys Leu Gly Asp Asn Ala Tyr Pro Phe 
            100                 105                 110         


Xaa Leu Gln Met Val Xaa Asn Leu Pro Cys Ser Val Xaa Leu Gln Pro 
        115                 120                 125             


Gly Pro Glu Asp Ala Gly Lys Pro Cys Gly Ile Asp Phe Glu Val Lys 
    130                 135                 140                 


Ser Phe Cys Ala Glu Asn Pro Glu Glu Xaa Val Ser Lys Arg Asp Tyr 
145                 150                 155                 160 


Val Arg Leu Val Val Arg Lys Val Gln Phe Ala Pro Pro Glu Ala Gly 
                165                 170                 175     


Pro Gly Pro Ser Ala Gln Xaa Ile Arg Arg Phe Leu Leu Ser Ala Gln 
            180                 185                 190         


Pro Leu Gln Leu Gln Ala Trp Met Asp Arg Glu Val His Tyr His Gly 
        195                 200                 205             


Glu Pro Ile Ser Val Asn Val Ser Ile Asn Asn Cys Xaa Asn Lys Val 
    210                 215                 220                 


Ile Lys Lys Ile Lys Ile Ser Val Asp Gln Ile Xaa Asp Val Val Leu 
225                 230                 235                 240 


Tyr Ser Leu Asp Lys Tyr Xaa Lys Xaa Val Phe Ile Gln Glu Phe Xaa 
                245                 250                 255     


Glu Xaa Val Ala Ala Asn Ser Ser Phe Ser Gln Ser Phe Ala Val Xaa 
            260                 265                 270         


Pro Ile Leu Ala Ala Ser Cys Gln Lys Arg Gly Leu Ala Leu Asp Gly 
        275                 280                 285             


Lys Leu Lys His Glu Asp Xaa Asn Leu Ala Ser Ser Xaa Ile Ile Arg 
    290                 295                 300                 


Pro Gly Met Asp Lys Glu Leu Leu Gly Ile Leu Val Ser Tyr Lys Val 
305                 310                 315                 320 


Arg Val Asn Leu Met Val Ser Cys Gly Gly Ile Leu Gly Asp Leu Xaa 
                325                 330                 335     


Ala Ser Asp Val Gly Val Glu Leu Pro Leu Val Leu Ile His Pro Lys 
            340                 345                 350         


Pro Ser His Ala Ser Ala Ser Ser Glu Asp Ile Val Ile Glu Glu Phe 
        355                 360                 365             


Xaa Arg Lys Gly Glu Glu Glu Ser Gln Lys Ala Val Glu Ala Glu Gly 
    370                 375                 380                 


Asp Glu Gly Ser 
385             


<210> 3295
<211> 410
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<400> 3295
Met Gly Asp Lys Gly Xaa Arg Val Phe Lys Lys Ala Ser Pro Asn Gly 
1               5                   10                  15      


Lys Leu Xaa Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Ile Asp 
            20                  25                  30          


Leu Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Glu Tyr Leu 
        35                  40                  45              


Lys Glu Arg Arg Val Tyr Val Xaa Leu Xaa Cys Ala Phe Arg Tyr Gly 
    50                  55                  60                  


Arg Glu Asp Leu Asp Val Leu Gly Leu Xaa Phe Arg Lys Asp Leu Phe 
65                  70                  75                  80  


Val Ala Asn Val Gln Ser Phe Pro Pro Ala Pro Glu Asp Lys Lys Pro 
                85                  90                  95      


Leu Xaa Arg Leu Gln Glu Arg Leu Ile Lys Lys Leu Gly Glu His Ala 
            100                 105                 110         


Tyr Pro Phe Xaa Phe Glu Ile Pro Pro Asn Leu Pro Cys Ser Val Xaa 
        115                 120                 125             


Leu Gln Pro Gly Pro Glu Asp Xaa Gly Lys Ala Cys Gly Val Asp Tyr 
    130                 135                 140                 


Glu Val Lys Ala Phe Cys Ala Glu Asn Leu Glu Glu Lys Ile His Lys 
145                 150                 155                 160 


Arg Asn Ser Val Arg Leu Val Ile Arg Lys Val Gln Tyr Ala Pro Glu 
                165                 170                 175     


Arg Pro Gly Pro Gln Pro Xaa Ala Glu Xaa Xaa Arg Gln Phe Leu Met 
            180                 185                 190         


Ser Asp Lys Pro Leu His Leu Glu Ala Ser Leu Asp Lys Glu Ile Tyr 
        195                 200                 205             


Tyr His Gly Glu Pro Ile Ser Val Asn Val His Val Xaa Asn Asn Xaa 
    210                 215                 220                 


Asn Lys Xaa Val Lys Lys Ile Lys Ile Ser Val Arg Gln Tyr Ala Asp 
225                 230                 235                 240 


Ile Cys Leu Phe Asn Xaa Ala Gln Tyr Lys Cys Pro Val Ala Met Glu 
                245                 250                 255     


Glu Ala Asp Asp Xaa Val Ala Pro Ser Ser Xaa Phe Cys Lys Val Tyr 
            260                 265                 270         


Xaa Leu Xaa Pro Phe Leu Ala Asn Asn Arg Glu Lys Arg Gly Leu Ala 
        275                 280                 285             


Leu Asp Gly Lys Leu Lys His Glu Asp Xaa Asn Leu Ala Ser Ser Xaa 
    290                 295                 300                 


Leu Leu Arg Glu Gly Ala Asn Arg Glu Ile Leu Gly Ile Ile Val Ser 
305                 310                 315                 320 


Tyr Lys Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Asp Val Ala 
                325                 330                 335     


Val Glu Leu Pro Phe Xaa Leu Met His Pro Lys Pro Lys Glu Glu Pro 
            340                 345                 350         


Pro His Arg Glu Val Pro Glu Asn Glu Xaa Pro Val Asp Xaa Asn Leu 
        355                 360                 365             


Ile Glu Leu Asp Xaa Asn Asp Asp Asp Ile Val Phe Glu Asp Phe Ala 
    370                 375                 380                 


Arg Gln Arg Leu Lys Gly Met Lys Asp Asp Lys Glu Glu Glu Glu Asp 
385                 390                 395                 400 


Gly Xaa Gly Ser Pro Gln Leu Asn Asn Arg 
                405                 410 


<210> 3296
<211> 418
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<400> 3296
Met Gly Asp Lys Gly Xaa Arg Val Phe Lys Lys Ala Ser Pro Asn Gly 
1               5                   10                  15      


Lys Leu Xaa Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Ile Asp 
            20                  25                  30          


Leu Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Glu Tyr Leu 
        35                  40                  45              


Lys Glu Arg Arg Val Tyr Val Xaa Leu Xaa Cys Ala Phe Arg Tyr Gly 
    50                  55                  60                  


Arg Glu Asp Leu Asp Val Leu Gly Leu Xaa Phe Arg Lys Asp Leu Phe 
65                  70                  75                  80  


Val Ala Asn Val Gln Ser Phe Pro Pro Ala Pro Glu Asp Lys Lys Pro 
                85                  90                  95      


Leu Xaa Arg Leu Gln Glu Arg Leu Ile Lys Lys Leu Gly Glu His Ala 
            100                 105                 110         


Tyr Pro Phe Xaa Phe Glu Ile Pro Pro Asn Leu Pro Cys Ser Val Xaa 
        115                 120                 125             


Leu Gln Pro Gly Pro Glu Asp Xaa Gly Lys Ala Cys Gly Val Asp Tyr 
    130                 135                 140                 


Glu Val Lys Ala Phe Cys Ala Glu Asn Leu Glu Glu Lys Ile His Lys 
145                 150                 155                 160 


Arg Asn Ser Val Arg Leu Val Ile Arg Lys Val Gln Tyr Ala Pro Glu 
                165                 170                 175     


Arg Pro Gly Pro Gln Pro Xaa Ala Glu Xaa Xaa Arg Gln Phe Leu Met 
            180                 185                 190         


Ser Asp Lys Pro Leu His Leu Glu Ala Ser Leu Asp Lys Glu Ile Tyr 
        195                 200                 205             


Tyr His Gly Glu Pro Ile Ser Val Asn Val His Val Xaa Asn Asn Xaa 
    210                 215                 220                 


Asn Lys Xaa Val Lys Lys Ile Lys Ile Ser Val Arg Gln Tyr Ala Asp 
225                 230                 235                 240 


Ile Cys Leu Phe Asn Xaa Ala Gln Tyr Lys Cys Pro Val Ala Met Glu 
                245                 250                 255     


Glu Ala Asp Asp Xaa Val Ala Pro Ser Ser Xaa Phe Cys Lys Val Tyr 
            260                 265                 270         


Xaa Leu Xaa Pro Phe Leu Ala Asn Asn Arg Glu Lys Arg Gly Leu Ala 
        275                 280                 285             


Leu Asp Gly Lys Leu Lys His Glu Asp Xaa Asn Leu Ala Ser Ser Xaa 
    290                 295                 300                 


Leu Leu Arg Glu Gly Ala Asn Arg Glu Ile Leu Gly Ile Ile Val Ser 
305                 310                 315                 320 


Tyr Lys Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Leu Leu Gly 
                325                 330                 335     


Asp Leu Ala Ser Ser Asp Val Ala Val Glu Leu Pro Phe Xaa Leu Met 
            340                 345                 350         


His Pro Lys Pro Lys Glu Glu Pro Pro His Arg Glu Val Pro Glu Asn 
        355                 360                 365             


Glu Xaa Pro Val Asp Xaa Asn Leu Ile Glu Leu Asp Xaa Asn Asp Asp 
    370                 375                 380                 


Asp Ile Val Phe Glu Asp Phe Ala Arg Gln Arg Leu Lys Gly Met Lys 
385                 390                 395                 400 


Asp Asp Lys Glu Glu Glu Glu Asp Gly Xaa Gly Ser Pro Gln Leu Asn 
                405                 410                 415     


Asn Arg 
        


<210> 3297
<211> 258
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<400> 3297
Met Gly Val Phe Lys Lys Ala Ser Pro Asn Gly Lys Leu Xaa Val Tyr 
1               5                   10                  15      


Leu Gly Lys Arg Asp Phe Val Asp His Ile Asp Leu Val Asp Pro Val 
            20                  25                  30          


Asp Gly Val Val Leu Val Asp Pro Glu Tyr Leu Lys Glu Arg Arg Val 
        35                  40                  45              


Tyr Val Xaa Leu Xaa Cys Ala Phe Arg Tyr Gly Arg Glu Asp Leu Asp 
    50                  55                  60                  


Val Leu Gly Leu Xaa Phe Arg Lys Asp Leu Phe Val Ala Asn Val Gln 
65                  70                  75                  80  


Ser Phe Pro Pro Ala Pro Glu Asp Lys Lys Pro Leu Xaa Arg Leu Gln 
                85                  90                  95      


Glu Arg Leu Ile Lys Lys Leu Gly Glu His Ala Tyr Pro Phe Xaa Phe 
            100                 105                 110         


Glu Ile Pro Pro Asn Leu Pro Cys Ser Val Xaa Leu Gln Pro Gly Pro 
        115                 120                 125             


Glu Asp Xaa Gly Lys Ala Cys Gly Val Asp Tyr Glu Val Lys Ala Phe 
    130                 135                 140                 


Cys Ala Glu Asn Leu Glu Glu Lys Ile His Lys Arg Asn Ser Val Arg 
145                 150                 155                 160 


Leu Val Ile Arg Lys Val Gln Tyr Ala Pro Glu Arg Pro Gly Pro Gln 
                165                 170                 175     


Pro Xaa Ala Glu Xaa Xaa Arg Gln Phe Leu Met Ser Asp Lys Pro Leu 
            180                 185                 190         


His Leu Glu Ala Ser Leu Asp Lys Glu Ile Tyr Tyr His Gly Glu Pro 
        195                 200                 205             


Ile Ser Val Asn Val His Val Xaa Asn Asn Xaa Asn Lys Xaa Val Lys 
    210                 215                 220                 


Lys Ile Lys Ile Ser Val Arg Gln Tyr Ala Asp Ile Cys Leu Phe Asn 
225                 230                 235                 240 


Xaa Ala Gln Tyr Lys Cys Pro Val Ala Met Glu Glu Ala Asp Asp Xaa 
                245                 250                 255     


Val Ala 
        


<210> 3298
<211> 59
<212> PRT
<213> Homo sapiens

<400> 3298
Ser His Cys Lys Arg Trp Glu Arg Arg Gly His Gly Arg Arg Leu Ala 
1               5                   10                  15      


Ala Gly Glu Ala Glu Ser Val Gln Glu Gly Gln Ser Lys Trp Lys Ala 
            20                  25                  30          


His Arg Leu Pro Gly Lys Ala Gly Leu Cys Gly Pro His Arg Pro Arg 
        35                  40                  45              


Gly Pro Cys Gly Trp Cys Gly Pro Gly Gly Ser 
    50                  55                  


<210> 3299
<211> 69
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 3299
Xaa Gly Gly Arg Arg Arg Glu Arg Pro Ala Ala Ala Xaa Ala Arg Asp 
1               5                   10                  15      


Gly Arg Gly Glu Ala Met Glu Gly Asp Leu Gln Arg Glu Arg Leu Ser 
            20                  25                  30          


Ser Pro Ser Xaa Trp Glu Ser Gly Xaa Leu Trp Xaa Xaa Ser Xaa Ser 
        35                  40                  45              


Trp Xaa Leu Trp Met Val Trp Ser Trp Trp Ile Leu Ser Ile Ser Lys 
    50                  55                  60                  


Ser Gly Glu Ser Met 
65                  


<210> 3300
<211> 195
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<400> 3300
Xaa Arg Pro Gly Pro Gln Pro Xaa Ala Glu Xaa Xaa Arg Gln Phe Leu 
1               5                   10                  15      


Met Ser Asp Lys Pro Leu His Leu Glu Ala Ser Leu Asp Lys Glu Ile 
            20                  25                  30          


Tyr Tyr His Gly Glu Pro Ile Ser Val Asn Val His Val Xaa Asn Asn 
        35                  40                  45              


Xaa Asn Lys Xaa Val Lys Lys Ile Lys Ile Ser Val Arg Gln Tyr Ala 
    50                  55                  60                  


Asp Ile Cys Leu Phe Asn Xaa Ala Gln Tyr Lys Cys Pro Val Ala Met 
65                  70                  75                  80  


Glu Glu Ala Asp Asp Xaa Val Ala Pro Ser Ser Xaa Phe Cys Lys Val 
                85                  90                  95      


Tyr Xaa Leu Xaa Pro Phe Leu Ala Asn Asn Arg Glu Lys Arg Gly Leu 
            100                 105                 110         


Ala Leu Asp Gly Lys Leu Lys His Glu Asp Xaa Asn Leu Ala Ser Ser 
        115                 120                 125             


Xaa Leu Leu Arg Glu Gly Ala Asn Arg Glu Ile Leu Gly Ile Ile Val 
    130                 135                 140                 


Ser Tyr Lys Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Asp Val 
145                 150                 155                 160 


Ala Val Glu Leu Pro Phe Xaa Leu Met His Pro Lys Pro Lys Glu Glu 
                165                 170                 175     


Pro Pro His Arg Glu Val Met Xaa Xaa Leu Tyr Leu Arg Xaa Leu Leu 
            180                 185                 190         


Ala Arg Asp 
        195 


<210> 3301
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 3301
Xaa Val Cys Leu Pro Leu Pro Cys Arg Cys Ser Gly Glu Xaa Xaa Pro 
1               5                   10                  15      


Xaa Pro Gly Pro Val Pro Ser Ala Glu Cys Ser Arg Arg Pro Val Gln 
            20                  25                  30          


Met Glu Ser Ser Pro Ser Xaa Trp Glu Ser Gly Xaa Leu Trp Xaa Xaa 
        35                  40                  45              


Ser Xaa Ser Trp Xaa Leu Trp Met Val Trp Ser Trp Trp Ile Leu Ser 
    50                  55                  60                  


Ile Ser Lys Ser Gly Glu Ser Met 
65                  70          


<210> 3302
<211> 196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(177)
<223> Selenocysteine

<400> 3302
Gly Gly Glu Xaa Arg Asp Gln Leu Xaa Val Tyr Leu Gly Lys Arg Asp 
1               5                   10                  15      


Phe Val Asp His Leu Asp Lys Val Asp Pro Val Asp Gly Val Val Leu 
            20                  25                  30          


Val Asp Pro Asp Tyr Leu Lys Asp Arg Lys Val Phe Val Xaa Leu Xaa 
        35                  40                  45              


Cys Ala Phe Arg Tyr Gly Arg Glu Asp Leu Asp Val Leu Gly Leu Ser 
    50                  55                  60                  


Phe Arg Lys Asp Leu Phe Ile Ala Xaa Tyr Gln Ala Phe Pro Pro Val 
65                  70                  75                  80  


Pro Asn Pro Pro Arg Pro Pro Xaa Arg Leu Gln Asp Arg Leu Leu Arg 
                85                  90                  95      


Lys Leu Gly Gln His Ala His Pro Phe Phe Phe Xaa Ile Pro Gln Asn 
            100                 105                 110         


Leu Pro Cys Ser Val Xaa Leu Gln Pro Gly Pro Glu Asp Xaa Gly Lys 
        115                 120                 125             


Ala Cys Gly Val Asp Phe Glu Ile Arg Ala Phe Cys Ala Lys Ser Leu 
    130                 135                 140                 


Glu Glu Lys Ser His Lys Arg Asn Ser Val Arg Leu Val Ile Arg Lys 
145                 150                 155                 160 


Val Gln Phe Ala Pro Glu Lys Pro Gly Pro Gln Pro Ser Ala Glu Xaa 
                165                 170                 175     


Xaa Arg His Phe Leu Met Ser Asp Arg Ser Leu His Leu Glu Ala Ser 
            180                 185                 190         


Leu Asp Lys Glu 
        195     


<210> 3303
<211> 330
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<400> 3303
Met Gly Glu Lys Pro Gly Xaa Arg Val Phe Lys Lys Ser Ser Pro Asn 
1               5                   10                  15      


Cys Lys Leu Xaa Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Leu 
            20                  25                  30          


Asp Lys Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Asp Tyr 
        35                  40                  45              


Leu Lys Asp Arg Lys Val Phe Val Xaa Leu Xaa Cys Ala Phe Arg Tyr 
    50                  55                  60                  


Gly Arg Glu Asp Leu Asp Val Leu Gly Leu Ser Phe Arg Lys Asp Leu 
65                  70                  75                  80  


Phe Ile Ala Xaa Tyr Gln Ala Phe Pro Pro Val Pro Asn Pro Pro Arg 
                85                  90                  95      


Pro Pro Xaa Arg Leu Gln Asp Arg Leu Leu Arg Lys Leu Gly Gln His 
            100                 105                 110         


Ala His Pro Phe Phe Phe Xaa Ile Pro Gln Asn Leu Pro Cys Ser Val 
        115                 120                 125             


Xaa Leu Gln Pro Gly Pro Glu Asp Xaa Gly Lys Ala Cys Gly Val Asp 
    130                 135                 140                 


Phe Glu Ile Arg Ala Phe Cys Ala Lys Ser Leu Glu Glu Lys Ser His 
145                 150                 155                 160 


Lys Arg Asn Ser Val Arg Leu Val Ile Arg Lys Val Gln Phe Ala Pro 
                165                 170                 175     


Glu Lys Pro Gly Pro Gln Pro Ser Ala Glu Xaa Xaa Arg His Phe Leu 
            180                 185                 190         


Met Ser Asp Arg Ser Leu His Leu Glu Ala Ser Leu Asp Lys Glu Leu 
        195                 200                 205             


Tyr Tyr His Gly Glu Pro Leu Asn Val Asn Val His Val Xaa Asn Asn 
    210                 215                 220                 


Ser Xaa Lys Xaa Val Lys Lys Ile Lys Val Ser Val Arg Gln Tyr Ala 
225                 230                 235                 240 


Asp Ile Cys Leu Phe Ser Xaa Ala Gln Tyr Lys Cys Pro Val Ala Gln 
                245                 250                 255     


Leu Glu Gln Asp Asp Gln Arg Glu Gly Gly Cys Gln Gln Gly Gly Ala 
            260                 265                 270         


Gly Asn Pro Gly Val Leu Gln Gly Gln Gly Glu Ala Gly Gly Val Ser 
        275                 280                 285             


Arg Arg Gly Cys Leu Cys Gly Ala Ala Phe Cys Ser Tyr Ala Pro Gln 
    290                 295                 300                 


Ala Pro Arg Pro His Pro Pro Pro Gln Xaa Pro Val Ser Arg Ser Gly 
305                 310                 315                 320 


Asp Arg Cys Pro Cys Gly His Gln Pro His 
                325                 330 


<210> 3304
<211> 409
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<400> 3304
Met Gly Glu Lys Pro Gly Xaa Arg Val Phe Lys Lys Ser Ser Pro Asn 
1               5                   10                  15      


Cys Lys Leu Xaa Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Leu 
            20                  25                  30          


Asp Lys Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Asp Tyr 
        35                  40                  45              


Leu Lys Asp Arg Lys Val Phe Val Xaa Leu Xaa Cys Ala Phe Arg Tyr 
    50                  55                  60                  


Gly Arg Glu Asp Leu Asp Val Leu Gly Leu Ser Phe Arg Lys Asp Leu 
65                  70                  75                  80  


Phe Ile Ala Xaa Tyr Gln Ala Phe Pro Pro Val Pro Asn Pro Pro Arg 
                85                  90                  95      


Pro Pro Xaa Arg Leu Gln Asp Arg Leu Leu Arg Lys Leu Gly Gln His 
            100                 105                 110         


Ala His Pro Phe Phe Phe Xaa Ile Pro Gln Asn Leu Pro Cys Ser Val 
        115                 120                 125             


Xaa Leu Gln Pro Gly Pro Glu Asp Xaa Gly Lys Ala Cys Gly Val Asp 
    130                 135                 140                 


Phe Glu Ile Arg Ala Phe Cys Ala Lys Ser Leu Glu Glu Lys Ser His 
145                 150                 155                 160 


Lys Arg Asn Ser Val Arg Leu Val Ile Arg Lys Val Gln Phe Ala Pro 
                165                 170                 175     


Glu Lys Pro Gly Pro Gln Pro Ser Ala Glu Xaa Xaa Arg His Phe Leu 
            180                 185                 190         


Met Ser Asp Arg Ser Leu His Leu Glu Ala Ser Leu Asp Lys Glu Leu 
        195                 200                 205             


Tyr Tyr His Gly Glu Pro Leu Asn Val Asn Val His Val Xaa Asn Asn 
    210                 215                 220                 


Ser Xaa Lys Xaa Val Lys Lys Ile Lys Val Ser Val Arg Gln Tyr Ala 
225                 230                 235                 240 


Asp Ile Cys Leu Phe Ser Xaa Ala Gln Tyr Lys Cys Pro Val Ala Gln 
                245                 250                 255     


Leu Glu Gln Asp Asp Gln Val Ser Pro Ser Ser Xaa Phe Cys Lys Val 
            260                 265                 270         


Tyr Xaa Ile Xaa Pro Leu Leu Ser Asp Asn Arg Glu Lys Arg Gly Leu 
        275                 280                 285             


Ala Leu Asp Gly Lys Leu Lys His Glu Asp Xaa Asn Leu Ala Ser Ser 
    290                 295                 300                 


Xaa Ile Val Lys Glu Gly Ala Asn Lys Glu Val Leu Gly Ile Leu Val 
305                 310                 315                 320 


Ser Tyr Arg Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Asp Val 
                325                 330                 335     


Ser Val Glu Leu Pro Phe Val Leu Met His Pro Lys Pro His Asp His 
            340                 345                 350         


Ile Pro Leu Pro Arg Pro Gln Ser Ala Ala Pro Glu Xaa Asp Val Pro 
        355                 360                 365             


Val Asp Xaa Asn Leu Ile Glu Phe Asp Xaa Asn Tyr Ala Xaa Asp Asp 
    370                 375                 380                 


Asp Ile Val Phe Glu Asp Phe Ala Arg Leu Arg Leu Lys Gly Met Lys 
385                 390                 395                 400 


Asp Asp Asp Tyr Asp Asp Gln Leu Cys 
                405                 


<210> 3305
<211> 430
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<400> 3305
Met Gly Glu Lys Pro Gly Xaa Arg Val Phe Lys Lys Ser Ser Pro Asn 
1               5                   10                  15      


Cys Lys Leu Xaa Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Leu 
            20                  25                  30          


Asp Lys Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Asp Tyr 
        35                  40                  45              


Leu Lys Asp Arg Lys Val Phe Val Xaa Leu Xaa Cys Ala Phe Arg Tyr 
    50                  55                  60                  


Gly Arg Glu Asp Leu Asp Val Leu Gly Leu Ser Phe Arg Lys Asp Leu 
65                  70                  75                  80  


Phe Ile Ala Xaa Tyr Gln Ala Phe Pro Pro Val Pro Asn Pro Pro Arg 
                85                  90                  95      


Pro Pro Xaa Arg Leu Gln Asp Arg Leu Leu Arg Lys Leu Gly Gln His 
            100                 105                 110         


Ala His Pro Phe Phe Phe Xaa Val Arg Met Pro Leu Pro Ser Glu Gly 
        115                 120                 125             


Gln Gly Ala Gly Ala Gly Xaa Val Ser Gly Val Gly Ile Pro Gln Asn 
    130                 135                 140                 


Leu Pro Cys Ser Val Xaa Leu Gln Pro Gly Pro Glu Asp Xaa Gly Lys 
145                 150                 155                 160 


Ala Cys Gly Val Asp Phe Glu Ile Arg Ala Phe Cys Ala Lys Ser Leu 
                165                 170                 175     


Glu Glu Lys Ser His Lys Arg Asn Ser Val Arg Leu Val Ile Arg Lys 
            180                 185                 190         


Val Gln Phe Ala Pro Glu Lys Pro Gly Pro Gln Pro Ser Ala Glu Xaa 
        195                 200                 205             


Xaa Arg His Phe Leu Met Ser Asp Arg Ser Leu His Leu Glu Ala Ser 
    210                 215                 220                 


Leu Asp Lys Glu Leu Tyr Tyr His Gly Glu Pro Leu Asn Val Asn Val 
225                 230                 235                 240 


His Val Xaa Asn Asn Ser Xaa Lys Xaa Val Lys Lys Ile Lys Val Ser 
                245                 250                 255     


Val Arg Gln Tyr Ala Asp Ile Cys Leu Phe Ser Xaa Ala Gln Tyr Lys 
            260                 265                 270         


Cys Pro Val Ala Gln Leu Glu Gln Asp Asp Gln Val Ser Pro Ser Ser 
        275                 280                 285             


Xaa Phe Cys Lys Val Tyr Xaa Ile Xaa Pro Leu Leu Ser Asp Asn Arg 
    290                 295                 300                 


Glu Lys Arg Gly Leu Ala Leu Asp Gly Lys Leu Lys His Glu Asp Xaa 
305                 310                 315                 320 


Asn Leu Ala Ser Ser Xaa Ile Val Lys Glu Gly Ala Asn Lys Glu Val 
                325                 330                 335     


Leu Gly Ile Leu Val Ser Tyr Arg Val Lys Val Lys Leu Val Val Ser 
            340                 345                 350         


Arg Gly Gly Asp Val Ser Val Glu Leu Pro Phe Val Leu Met His Pro 
        355                 360                 365             


Lys Pro His Asp His Ile Pro Leu Pro Arg Pro Gln Ser Ala Ala Pro 
    370                 375                 380                 


Glu Xaa Asp Val Pro Val Asp Xaa Asn Leu Ile Glu Phe Asp Xaa Asn 
385                 390                 395                 400 


Tyr Ala Xaa Asp Asp Asp Ile Val Phe Glu Asp Phe Ala Arg Leu Arg 
                405                 410                 415     


Leu Lys Gly Met Lys Asp Asp Asp Tyr Asp Asp Gln Leu Cys 
            420                 425                 430 


<210> 3306
<211> 64
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<400> 3306
Met Gly Glu Lys Pro Gly Xaa Arg Val Phe Lys Lys Ser Ser Pro Asn 
1               5                   10                  15      


Cys Lys Leu Xaa Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Leu 
            20                  25                  30          


Asp Lys Val Asp Pro Val Asp Xaa Pro Glu Ser Ser Met Leu Arg His 
        35                  40                  45              


Xaa Ala Ala Arg Pro Arg Gly Tyr Arg Lys Gly Leu Arg Arg Arg Leu 
    50                  55                  60                  


<210> 3307
<211> 394
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<400> 3307
Met Gly Glu Lys Pro Gly Xaa Arg Val Phe Lys Lys Ser Ser Pro Asn 
1               5                   10                  15      


Cys Lys Leu Xaa Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Leu 
            20                  25                  30          


Asp Lys Val Asp Pro Val Val Phe Val Xaa Leu Xaa Cys Ala Phe Arg 
        35                  40                  45              


Tyr Gly Arg Glu Asp Leu Asp Val Leu Gly Leu Ser Phe Arg Lys Asp 
    50                  55                  60                  


Leu Phe Ile Ala Xaa Tyr Gln Ala Phe Pro Pro Val Pro Asn Pro Pro 
65                  70                  75                  80  


Arg Pro Pro Xaa Arg Leu Gln Asp Arg Leu Leu Arg Lys Leu Gly Gln 
                85                  90                  95      


His Ala His Pro Phe Phe Phe Xaa Ile Pro Gln Asn Leu Pro Cys Ser 
            100                 105                 110         


Val Xaa Leu Gln Pro Gly Pro Glu Asp Xaa Gly Lys Ala Cys Gly Val 
        115                 120                 125             


Asp Phe Glu Ile Arg Ala Phe Cys Ala Lys Ser Leu Glu Glu Lys Ser 
    130                 135                 140                 


His Lys Arg Asn Ser Val Arg Leu Val Ile Arg Lys Val Gln Phe Ala 
145                 150                 155                 160 


Pro Glu Lys Pro Gly Pro Gln Pro Ser Ala Glu Xaa Xaa Arg His Phe 
                165                 170                 175     


Leu Met Ser Asp Arg Ser Leu His Leu Glu Ala Ser Leu Asp Lys Glu 
            180                 185                 190         


Leu Tyr Tyr His Gly Glu Pro Leu Asn Val Asn Val His Val Xaa Asn 
        195                 200                 205             


Asn Ser Xaa Lys Xaa Val Lys Lys Ile Lys Val Ser Val Arg Gln Tyr 
    210                 215                 220                 


Ala Asp Ile Cys Leu Phe Ser Xaa Ala Gln Tyr Lys Cys Pro Val Ala 
225                 230                 235                 240 


Gln Leu Glu Gln Asp Asp Gln Val Ser Pro Ser Ser Xaa Phe Cys Lys 
                245                 250                 255     


Val Tyr Xaa Ile Xaa Pro Leu Leu Ser Asp Asn Arg Glu Lys Arg Gly 
            260                 265                 270         


Leu Ala Leu Asp Gly Lys Leu Lys His Glu Asp Xaa Asn Leu Ala Ser 
        275                 280                 285             


Ser Xaa Ile Val Lys Glu Gly Ala Asn Lys Glu Val Leu Gly Ile Leu 
    290                 295                 300                 


Val Ser Tyr Arg Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Asp 
305                 310                 315                 320 


Val Ser Val Glu Leu Pro Phe Val Leu Met His Pro Lys Pro His Asp 
                325                 330                 335     


His Ile Pro Leu Pro Arg Pro Gln Ser Ala Ala Pro Glu Xaa Asp Val 
            340                 345                 350         


Pro Val Asp Xaa Asn Leu Ile Glu Phe Asp Xaa Asn Tyr Ala Xaa Asp 
        355                 360                 365             


Asp Asp Ile Val Phe Glu Asp Phe Ala Arg Leu Arg Leu Lys Gly Met 
    370                 375                 380                 


Lys Asp Asp Asp Tyr Asp Asp Gln Leu Cys 
385                 390                 


<210> 3308
<211> 406
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<400> 3308
Met Gly Glu Lys Pro Gly Xaa Arg Val Phe Lys Lys Ser Ser Pro Asn 
1               5                   10                  15      


Cys Lys Leu Xaa Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Leu 
            20                  25                  30          


Asp Lys Val Asp Pro Val Val Phe Val Xaa Leu Xaa Cys Ala Phe Arg 
        35                  40                  45              


Tyr Gly Arg Glu Asp Leu Asp Val Leu Gly Leu Ser Phe Arg Lys Asp 
    50                  55                  60                  


Leu Phe Ile Ala Xaa Tyr Gln Ala Phe Pro Pro Val Pro Asn Pro Pro 
65                  70                  75                  80  


Arg Pro Pro Xaa Arg Leu Gln Asp Arg Leu Leu Arg Lys Leu Gly Gln 
                85                  90                  95      


His Ala His Pro Phe Phe Phe Xaa Ile Pro Gln Asn Leu Pro Cys Ser 
            100                 105                 110         


Val Xaa Leu Gln Pro Gly Pro Glu Asp Xaa Gly Lys Ala Cys Gly Val 
        115                 120                 125             


Asp Phe Glu Ile Arg Ala Phe Cys Ala Lys Ser Leu Glu Glu Lys Ser 
    130                 135                 140                 


His Lys Arg Asn Ser Val Arg Leu Val Ile Arg Lys Val Gln Phe Ala 
145                 150                 155                 160 


Pro Glu Lys Pro Gly Pro Gln Pro Ser Ala Glu Xaa Xaa Arg His Phe 
                165                 170                 175     


Leu Met Ser Asp Arg Ser Leu His Leu Glu Ala Ser Leu Asp Lys Glu 
            180                 185                 190         


Leu Tyr Tyr His Gly Glu Pro Leu Asn Val Asn Val His Val Xaa Asn 
        195                 200                 205             


Asn Ser Xaa Lys Xaa Val Lys Lys Ile Lys Val Ser Val Arg Gln Tyr 
    210                 215                 220                 


Ala Asp Ile Cys Leu Phe Ser Xaa Ala Gln Tyr Lys Cys Pro Val Ala 
225                 230                 235                 240 


Gln Leu Glu Gln Asp Asp Gln Val Ser Pro Ser Ser Xaa Phe Cys Lys 
                245                 250                 255     


Val Tyr Xaa Ile Xaa Pro Leu Leu Ser Asp Asn Arg Glu Lys Arg Gly 
            260                 265                 270         


Leu Ala Leu Asp Gly Lys Leu Lys His Glu Asp Xaa Asn Leu Ala Ser 
        275                 280                 285             


Ser Xaa Ile Val Lys Glu Gly Ala Asn Lys Glu Val Leu Gly Ile Leu 
    290                 295                 300                 


Val Ser Tyr Arg Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Asp 
305                 310                 315                 320 


Val Ser Val Glu Leu Pro Phe Val Leu Met His Pro Lys Pro His Asp 
                325                 330                 335     


His Ile Pro Leu Pro Arg Pro Gln Ser Ala Pro Xaa Pro Xaa Pro Pro 
            340                 345                 350         


Leu Pro Val Pro Pro Ala Ala Pro Glu Xaa Asp Val Pro Val Asp Xaa 
        355                 360                 365             


Asn Leu Ile Glu Phe Asp Xaa Asn Tyr Ala Xaa Asp Asp Asp Ile Val 
    370                 375                 380                 


Phe Glu Asp Phe Ala Arg Leu Arg Leu Lys Gly Met Lys Asp Asp Asp 
385                 390                 395                 400 


Tyr Asp Asp Gln Leu Cys 
                405     


<210> 3309
<211> 74
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<400> 3309
Met Gly Glu Lys Pro Gly Xaa Arg Val Phe Lys Lys Ser Ser Pro Asn 
1               5                   10                  15      


Cys Lys Pro Leu Ala Ala Glu Ala Ala Gln Pro Glu Pro Ala Xaa Gly 
            20                  25                  30          


Leu Gly Gly Ala Gly Leu Gly Pro Gln Ala Arg Pro Gln Arg Arg Arg 
        35                  40                  45              


Pro Lys Ala Ser His Val Pro Val Ala Leu Leu Gly Ala Asn Pro Ser 
    50                  55                  60                  


Ser Pro Cys Xaa Trp Ala Ser Gly Xaa Ser 
65                  70                  


<210> 3310
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<400> 3310
Met Ser Asp Arg Ser Leu His Leu Glu Ala Ser Leu Asp Lys Glu Leu 
1               5                   10                  15      


Tyr Tyr His Gly Glu Pro Leu Asn Val Asn Val His Val Xaa Asn Asn 
            20                  25                  30          


Ser Xaa Lys Xaa Val Lys Lys Ile Lys Val Ser Val Arg Gln Tyr Ala 
        35                  40                  45              


Asp Ile Cys Leu Phe Ser Xaa Ala Gln Tyr Lys Cys Pro Val Ala Gln 
    50                  55                  60                  


Leu Glu Gln Asp Asp Gln Val Ser Pro Ser Ser Xaa Phe Cys Lys Val 
65                  70                  75                  80  


Tyr Xaa Ile Xaa Pro Leu Leu Ser Asp Asn Arg Glu Lys Arg Gly Leu 
                85                  90                  95      


Ala Leu Asp Gly Lys Leu Lys His Glu Asp Xaa Asn Leu Ala Ser Ser 
            100                 105                 110         


Xaa 
    


<210> 3311
<211> 217
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<400> 3311
Met Ser Asp Arg Ser Leu His Leu Glu Ala Ser Leu Asp Lys Glu Leu 
1               5                   10                  15      


Tyr Tyr His Gly Glu Pro Leu Asn Val Asn Val His Val Xaa Asn Asn 
            20                  25                  30          


Ser Xaa Lys Xaa Val Lys Lys Ile Lys Val Ser Val Arg Gln Tyr Ala 
        35                  40                  45              


Asp Ile Cys Leu Phe Ser Xaa Ala Gln Tyr Lys Cys Pro Val Ala Gln 
    50                  55                  60                  


Leu Glu Gln Asp Asp Gln Val Ser Pro Ser Ser Xaa Phe Cys Lys Val 
65                  70                  75                  80  


Tyr Xaa Ile Xaa Pro Leu Leu Ser Asp Asn Arg Glu Lys Arg Gly Leu 
                85                  90                  95      


Ala Leu Asp Gly Lys Leu Lys His Glu Asp Xaa Asn Leu Ala Ser Ser 
            100                 105                 110         


Xaa Ile Val Lys Glu Gly Ala Asn Lys Glu Val Leu Gly Ile Leu Val 
        115                 120                 125             


Ser Tyr Arg Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Asp Val 
    130                 135                 140                 


Ser Val Glu Leu Pro Phe Val Leu Met His Pro Lys Pro His Asp His 
145                 150                 155                 160 


Ile Pro Leu Pro Arg Pro Gln Ser Ala Ala Pro Glu Xaa Asp Val Pro 
                165                 170                 175     


Val Asp Xaa Asn Leu Ile Glu Phe Asp Xaa Asn Tyr Ala Xaa Asp Asp 
            180                 185                 190         


Asp Ile Val Phe Glu Asp Phe Ala Arg Leu Arg Leu Lys Gly Met Lys 
        195                 200                 205             


Asp Asp Asp Tyr Asp Asp Gln Leu Cys 
    210                 215         


<210> 3312
<211> 6
<212> PRT
<213> Homo sapiens

<400> 3312
Met Ala Arg Gly Ala Arg 
1               5       


<210> 3313
<211> 407
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<400> 3313
Met Leu Phe Asp Lys Val Lys Ala Phe Ser Val Gln Leu Asp Gly Ala 
1               5                   10                  15      


Xaa Ala Gly Val Glu Pro Val Phe Ser Gly Gly Gln Ala Val Ala Gly 
            20                  25                  30          


Arg Val Leu Leu Glu Leu Ser Ser Ala Ala Arg Val Gly Ala Leu Arg 
        35                  40                  45              


Leu Arg Ala Arg Gly Arg Ala His Val His Trp Xaa Glu Ser Arg Ser 
    50                  55                  60                  


Ala Gly Ser Ser Xaa Ala Tyr Xaa Gln Ser Tyr Ser Glu Arg Val Glu 
65                  70                  75                  80  


Val Val Ser His Arg Ala Xaa Leu Leu Ala Pro Asp Xaa Gly Glu Xaa 
                85                  90                  95      


Xaa Xaa Leu Pro Pro Gly Arg His Glu Phe Leu Phe Ser Phe Gln Leu 
            100                 105                 110         


Pro Pro Xaa Leu Val Xaa Ser Phe Glu Gly Lys His Gly Ser Val Arg 
        115                 120                 125             


Tyr Cys Ile Lys Ala Xaa Leu His Arg Pro Trp Val Pro Ala Arg Arg 
    130                 135                 140                 


Ala Arg Lys Val Phe Xaa Val Ile Glu Pro Val Asp Ile Asn Xaa Pro 
145                 150                 155                 160 


Ala Leu Leu Ala Pro Gln Ala Gly Ala Arg Glu Lys Val Ala Arg Ser 
                165                 170                 175     


Trp Tyr Cys Asn Arg Gly Leu Val Ser Leu Ser Ala Lys Ile Asp Arg 
            180                 185                 190         


Lys Gly Tyr Xaa Pro Gly Glu Val Ile Pro Val Phe Ala Glu Ile Asp 
        195                 200                 205             


Asn Gly Ser Xaa Arg Pro Val Leu Pro Arg Ala Ala Val Val Gln Xaa 
    210                 215                 220                 


Gln Xaa Phe Met Ala Arg Gly Ala Arg Lys Gln Lys Arg Ala Val Val 
225                 230                 235                 240 


Ala Ser Leu Ala Gly Glu Pro Val Gly Pro Gly Gln Arg Ala Leu Trp 
                245                 250                 255     


Gln Gly Arg Ala Leu Arg Ile Pro Pro Val Gly Pro Ser Ile Leu His 
            260                 265                 270         


Cys Arg Val Leu His Val Asp Tyr Ala Leu Lys Val Cys Val Asp Ile 
        275                 280                 285             


Pro Gly Xaa Ser Lys Leu Leu Leu Glu Leu Pro Leu Val Ile Gly Xaa 
    290                 295                 300                 


Ile Pro Leu His Pro Phe Gly Ser Arg Ser Ser Ser Val Gly Ser His 
305                 310                 315                 320 


Ala Ser Phe Leu Leu Asp Trp Arg Leu Gly Ala Leu Pro Glu Arg Pro 
                325                 330                 335     


Glu Ala Pro Pro Glu Tyr Ser Glu Val Val Ala Asp Xaa Glu Glu Ala 
            340                 345                 350         


Ala Leu Gly Gln Ser Pro Phe Pro Leu Pro Gln Asp Pro Asp Met Ser 
        355                 360                 365             


Leu Glu Gly Pro Phe Phe Ala Tyr Ile Gln Glu Phe Arg Tyr Arg Pro 
    370                 375                 380                 


Pro Pro Leu Tyr Ser Glu Glu Asp Pro Asn Pro Leu Leu Gly Asp Met 
385                 390                 395                 400 


Arg Pro Arg Cys Met Xaa Cys 
                405         


<210> 3314
<211> 322
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<400> 3314
Met Leu Phe Asp Lys Val Lys Ala Phe Ser Val Gln Leu Asp Gly Ala 
1               5                   10                  15      


Xaa Ala Gly Val Glu Pro Val Phe Ser Gly Gly Gln Ala Val Ala Gly 
            20                  25                  30          


Arg Val Leu Leu Glu Leu Ser Ser Ala Ala Arg Val Gly Ala Leu Arg 
        35                  40                  45              


Leu Arg Ala Arg Gly Arg Ala His Val His Trp Xaa Glu Ser Arg Ser 
    50                  55                  60                  


Ala Gly Ser Ser Xaa Ala Tyr Xaa Gln Ser Tyr Ser Glu Arg Val Glu 
65                  70                  75                  80  


Val Val Ser His Arg Ala Xaa Leu Leu Ala Pro Gly Xaa Asp Gly Gly 
                85                  90                  95      


Pro Leu Leu Gln His Gln Leu Cys Ala Ser His His Leu Asp Gly Gly 
            100                 105                 110         


Xaa Ser Val Ser Pro Gly Xaa Pro Ala Gln Pro Leu Ser Arg Leu Leu 
        115                 120                 125             


Phe Leu Leu Pro Ala Asp Xaa Gly Glu Xaa Xaa Xaa Leu Pro Pro Gly 
    130                 135                 140                 


Arg His Glu Phe Leu Phe Ser Phe Gln Leu Pro Pro Xaa Leu Val Xaa 
145                 150                 155                 160 


Ser Phe Glu Gly Lys His Gly Ser Val Arg Tyr Cys Ile Lys Ala Xaa 
                165                 170                 175     


Leu His Arg Pro Trp Val Pro Ala Arg Arg Ala Arg Lys Val Phe Xaa 
            180                 185                 190         


Val Ile Glu Pro Val Asp Ile Asn Xaa Pro Ala Leu Leu Ala Pro Gln 
        195                 200                 205             


Ala Gly Ala Arg Glu Lys Val Ala Arg Ser Trp Tyr Cys Asn Arg Gly 
    210                 215                 220                 


Leu Val Ser Leu Ser Ala Lys Ile Asp Arg Lys Gly Tyr Xaa Pro Gly 
225                 230                 235                 240 


Glu Val Ile Pro Val Phe Ala Glu Ile Asp Asn Gly Ser Xaa Arg Pro 
                245                 250                 255     


Val Leu Pro Arg Ala Ala Val Val Gln Xaa Gln Xaa Phe Met Ala Arg 
            260                 265                 270         


Gly Ala Arg Lys Gln Lys Arg Ala Val Val Ala Ser Leu Ala Gly Glu 
        275                 280                 285             


Pro Val Gly Pro Gly Gln Arg Ala Leu Trp Gln Gly Arg Ala Leu Arg 
    290                 295                 300                 


Ile Pro Pro Val Gly Pro Ser Ile Leu His Cys Arg Val Leu His Val 
305                 310                 315                 320 


Asp Tyr 
        


<210> 3315
<211> 402
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<400> 3315
Met Arg Ser Gly Gly Val Arg Ser Phe Ala Leu Glu Leu Ala Arg Gly 
1               5                   10                  15      


Pro Gly Gly Ala Tyr Arg Gly Gly Glu Arg Leu Cys Gly Arg Val Leu 
            20                  25                  30          


Leu Glu Ala Ala Ala Pro Leu Arg Val Arg Ala Leu Glu Val Lys Ala 
        35                  40                  45              


Arg Gly Gly Ala Ala Xaa His Trp Leu Glu Gly Arg Ser Val Gly Val 
    50                  55                  60                  


Asn Ala Val Ser Ser Asp Tyr Ala Ala Ala Glu Xaa Tyr Leu Arg Arg 
65                  70                  75                  80  


Arg Gln Leu Leu Leu Arg Asp Xaa Gly Glu Xaa Xaa Xaa Leu Pro Pro 
                85                  90                  95      


Gly Arg His Glu Phe Leu Phe Ser Phe Gln Leu Pro Pro Xaa Leu Val 
            100                 105                 110         


Xaa Ser Phe Glu Gly Lys His Gly Ser Val Arg Tyr Cys Ile Lys Ala 
        115                 120                 125             


Xaa Leu His Arg Pro Trp Val Pro Ala Arg Arg Ala Arg Lys Val Phe 
    130                 135                 140                 


Xaa Val Ile Glu Pro Val Asp Ile Asn Xaa Pro Ala Leu Leu Ala Pro 
145                 150                 155                 160 


Gln Ala Gly Ala Arg Glu Lys Val Ala Arg Ser Trp Tyr Cys Asn Arg 
                165                 170                 175     


Gly Leu Val Ser Leu Ser Ala Lys Ile Asp Arg Lys Gly Tyr Xaa Pro 
            180                 185                 190         


Gly Glu Val Ile Pro Val Phe Ala Glu Ile Asp Asn Gly Ser Xaa Arg 
        195                 200                 205             


Pro Val Leu Pro Arg Ala Ala Val Val Gln Xaa Gln Xaa Phe Met Ala 
    210                 215                 220                 


Arg Gly Ala Arg Lys Gln Lys Arg Ala Val Val Ala Ser Leu Ala Gly 
225                 230                 235                 240 


Glu Pro Val Gly Pro Gly Gln Arg Ala Leu Trp Gln Gly Arg Ala Leu 
                245                 250                 255     


Arg Ile Pro Pro Val Gly Pro Ser Ile Leu His Cys Arg Val Leu His 
            260                 265                 270         


Val Asp Tyr Ala Leu Lys Val Cys Val Asp Ile Pro Gly Xaa Ser Lys 
        275                 280                 285             


Leu Leu Leu Glu Leu Pro Leu Val Ile Gly Xaa Ile Pro Leu His Pro 
    290                 295                 300                 


Phe Gly Ser Arg Ser Ser Ser Val Gly Ser His Ala Ser Phe Leu Leu 
305                 310                 315                 320 


Asp Trp Arg Leu Gly Ala Leu Pro Glu Arg Pro Glu Ala Pro Pro Glu 
                325                 330                 335     


Tyr Ser Glu Val Val Ala Asp Xaa Glu Glu Ala Ala Leu Gly Gln Ser 
            340                 345                 350         


Pro Phe Pro Leu Pro Gln Asp Pro Asp Met Ser Leu Glu Gly Pro Phe 
        355                 360                 365             


Phe Ala Tyr Ile Gln Glu Phe Arg Tyr Arg Pro Pro Pro Leu Tyr Ser 
    370                 375                 380                 


Glu Glu Asp Pro Asn Pro Leu Leu Gly Asp Met Arg Pro Arg Cys Met 
385                 390                 395                 400 


Xaa Cys 
        


<210> 3316
<211> 414
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<400> 3316
Met Val Leu Gly Lys Val Lys Ser Leu Xaa Ile Ser Phe Asp Cys Leu 
1               5                   10                  15      


Asn Asp Ser Asn Val Pro Val Tyr Ser Ser Gly Asp Xaa Val Ser Gly 
            20                  25                  30          


Arg Val Asn Leu Glu Val Xaa Gly Glu Ile Arg Val Lys Ser Leu Lys 
        35                  40                  45              


Ile His Ala Arg Gly His Ala Lys Val Arg Trp Xaa Glu Ser Arg Asn 
    50                  55                  60                  


Ala Gly Ser Asn Xaa Ala Tyr Xaa Gln Asn Tyr Xaa Glu Glu Val Glu 
65                  70                  75                  80  


Tyr Phe Asn His Lys Asp Ile Leu Ile Gly His Glu Arg Asp Asp Asp 
                85                  90                  95      


Asn Ser Glu Glu Gly Phe His Xaa Ile His Ser Gly Arg His Glu Tyr 
            100                 105                 110         


Ala Phe Ser Phe Glu Leu Pro Gln Xaa Pro Leu Ala Xaa Ser Phe Glu 
        115                 120                 125             


Gly Arg His Gly Ser Val Arg Tyr Trp Val Lys Ala Glu Leu His Arg 
    130                 135                 140                 


Pro Trp Leu Leu Pro Val Lys Leu Lys Lys Glu Phe Xaa Val Phe Glu 
145                 150                 155                 160 


His Ile Asp Ile Asn Xaa Pro Ser Leu Leu Ser Pro Gln Ala Gly Xaa 
                165                 170                 175     


Lys Glu Lys Xaa Leu Cys Cys Trp Phe Cys Xaa Ser Gly Pro Ile Ser 
            180                 185                 190         


Leu Ser Ala Lys Ile Glu Arg Lys Gly Tyr Xaa Pro Gly Glu Ser Ile 
        195                 200                 205             


Gln Ile Phe Ala Glu Ile Glu Asn Cys Ser Ser Arg Met Val Val Pro 
    210                 215                 220                 


Lys Ala Ala Ile Tyr Gln Xaa Gln Ala Phe Tyr Ala Lys Gly Lys Met 
225                 230                 235                 240 


Lys Glu Val Lys Gln Leu Val Ala Asn Leu Arg Gly Glu Ser Leu Ser 
                245                 250                 255     


Ser Gly Lys Xaa Glu Xaa Trp Asn Gly Lys Leu Leu Lys Ile Pro Pro 
            260                 265                 270         


Val Ser Pro Ser Ile Leu Asp Cys Ser Ile Ile Arg Val Glu Tyr Ser 
        275                 280                 285             


Leu Met Val Tyr Val Asp Ile Pro Gly Ala Met Asp Leu Phe Leu Asn 
    290                 295                 300                 


Leu Pro Leu Val Ile Gly Xaa Ile Pro Leu His Pro Phe Gly Ser Arg 
305                 310                 315                 320 


Xaa Ser Ser Val Ser Ser Gln Cys Ser Met Asn Met Asn Trp Leu Ser 
                325                 330                 335     


Leu Ser Leu Pro Glu Arg Pro Glu Ala Pro Pro Ser Tyr Ala Glu Val 
            340                 345                 350         


Val Xaa Glu Glu Gln Arg Arg Asn Asn Leu Ala Pro Val Ser Ala Cys 
        355                 360                 365             


Asp Asp Phe Glu Arg Ala Leu Gln Gly Pro Leu Phe Ala Tyr Ile Gln 
    370                 375                 380                 


Glu Phe Arg Phe Leu Pro Pro Pro Leu Tyr Ser Glu Ile Asp Pro Asn 
385                 390                 395                 400 


Pro Asp Gln Ser Ala Asp Asp Arg Pro Ser Cys Pro Ser Arg 
                405                 410                 


<210> 3317
<211> 342
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<400> 3317
Met Gly Asp Arg Glu Glu Cys Leu Ser Xaa Pro Gln Pro Pro Met Ser 
1               5                   10                  15      


Val Val Lys Ser Ile Glu Leu Val Leu Pro Glu Asp Arg Ile Tyr Leu 
            20                  25                  30          


Ala Gly Ser Ser Ile Lys Gly Gln Val Ile Leu Xaa Leu Asn Ser Xaa 
        35                  40                  45              


Leu Val Asp Pro Ile Val Lys Val Glu Leu Val Gly Arg Gly Tyr Val 
    50                  55                  60                  


Glu Trp Ser Glu Glu Ala Gly Ala Ser Cys Asp Tyr Ser Arg Asn Val 
65                  70                  75                  80  


Ile Cys Asn Asn Lys Ala Asp Tyr Val His Lys Xaa Lys Xaa Phe Pro 
                85                  90                  95      


Val Glu Asp Asn Trp Leu Ser Ala Gly Ser His Xaa Phe Asp Phe His 
            100                 105                 110         


Phe Asn Leu Pro Pro Arg Leu Pro Ser Xaa Phe Xaa Ser Lys Phe Gly 
        115                 120                 125             


His Val Phe Tyr Phe Val Gln Ala Ser Cys Met Gly Arg Glu His Ile 
    130                 135                 140                 


Leu Ala Lys Lys Arg Met Tyr Leu Leu Val Gln Gly Xaa Ser Xaa Phe 
145                 150                 155                 160 


His Lys Glu Xaa Pro Phe Gln Asn Pro Leu Phe Val Glu Ala Glu Glu 
                165                 170                 175     


Lys Val Ser Tyr Asn Cys Cys Arg Gln Gly Xaa Val Cys Leu Gln Ile 
            180                 185                 190         


Gln Met Glu Arg Asn Xaa Phe Xaa Pro Gly Glu Lys Val Val Phe Xaa 
        195                 200                 205             


Xaa Glu Ile Asn Asn Gln Xaa Ser Lys Cys Ile Lys Xaa Val Val Phe 
    210                 215                 220                 


Ala Leu Tyr Ala His Ile Gln Tyr Glu Gly Phe Xaa Pro Ser Ala Glu 
225                 230                 235                 240 


Arg Arg Ser Arg Leu Asp Ser Ser Glu Leu Leu Arg Gln Glu Ala Asn 
                245                 250                 255     


Xaa Pro Val Xaa Arg Phe Asn Xaa Xaa Lys Val Val Ser Xaa Phe Asn 
            260                 265                 270         


Leu Pro Leu Leu Leu Ser Val Ser Ser Ser Xaa Gln Asp Gly Glu Ile 
        275                 280                 285             


Met His Xaa Arg Tyr Glu Leu Val Xaa Xaa Val His Leu Pro Trp Ser 
    290                 295                 300                 


Leu Xaa Ser Leu Lys Ala Lys Val Pro Ile Ile Ile Xaa Ser Ala Ser 
305                 310                 315                 320 


Val Asp Ser Ala Ile Cys Gln Leu Ser Glu Asp Gly Val Leu Pro Val 
                325                 330                 335     


Asn Pro Asp His Gln Asn 
            340         


<210> 3318
<211> 89
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 3318
Met Glu Leu Gly Leu Gly Gly Leu Ser Xaa Leu Ser His Cys Pro Trp 
1               5                   10                  15      


Pro Arg Gln Gln Ala Pro Leu Gly Leu Ser Ala Gln Pro Ala Leu Trp 
            20                  25                  30          


Pro Xaa Leu Ala Ala Leu Ala Leu Leu Ser Ser Val Ala Glu Ala Ser 
        35                  40                  45              


Leu Gly Ser Ala Pro Arg Ser Pro Ala Pro Arg Glu Gly Pro Pro Pro 
    50                  55                  60                  


Val Leu Ala Ser Pro Ala Gly His Leu Pro Gly Gly Arg Xaa Ala Arg 
65                  70                  75                  80  


Trp Cys Ser Gly Arg Ala Arg Arg Pro 
                85                  


<210> 3319
<211> 228
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<400> 3319
Met Glu Leu Gly Leu Gly Gly Leu Ser Xaa Leu Ser His Cys Pro Trp 
1               5                   10                  15      


Pro Arg Gln Gln Ala Pro Leu Gly Leu Ser Ala Gln Pro Ala Leu Trp 
            20                  25                  30          


Pro Xaa Leu Ala Ala Leu Ala Leu Leu Ser Ser Val Ala Glu Ala Ser 
        35                  40                  45              


Leu Gly Ser Ala Pro Arg Ser Pro Ala Pro Arg Glu Gly Pro Pro Pro 
    50                  55                  60                  


Val Leu Ala Ser Pro Ala Gly His Leu Pro Gly Gly Arg Xaa Ala Arg 
65                  70                  75                  80  


Trp Cys Ser Gly Arg Ala Arg Arg Pro Pro Pro Gln Pro Ser Arg Pro 
                85                  90                  95      


Ala Pro Pro Pro Pro Ala Pro Pro Ser Ala Leu Pro Arg Gly Gly Arg 
            100                 105                 110         


Ala Ala Arg Ala Gly Gly Pro Gly Ser Arg Ala Arg Ala Ala Gly Ala 
        115                 120                 125             


Arg Gly Cys Arg Leu Arg Ser Gln Leu Val Pro Val Arg Ala Leu Gly 
    130                 135                 140                 


Leu Gly His Arg Ser Asp Glu Leu Val Arg Phe Arg Phe Cys Ser Gly 
145                 150                 155                 160 


Ser Cys Arg Arg Ala Arg Ser Pro His Asp Leu Ser Leu Ala Ser Leu 
                165                 170                 175     


Leu Gly Ala Gly Ala Leu Arg Pro Pro Pro Gly Ser Arg Pro Val Ser 
            180                 185                 190         


Gln Pro Cys Cys Arg Pro Xaa Arg Tyr Glu Ala Val Ser Phe Met Asp 
        195                 200                 205             


Val Asn Ser Xaa Trp Arg Xaa Val Asp Arg Leu Ser Ala Xaa Ala Cys 
    210                 215                 220                 


Gly Cys Leu Gly 
225             


<210> 3320
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<400> 3320
Met Glu Leu Gly Leu Gly Gly Leu Ser Xaa Leu Ser His Cys Pro Trp 
1               5                   10                  15      


Pro Arg Gln Gln Ala Pro Leu Gly Leu Ser Ala Gln Pro Ala Leu Trp 
            20                  25                  30          


Pro Xaa Leu Ala Ala Leu Ala Leu Leu Ser Ser Val Ala Glu Ala Ser 
        35                  40                  45              


Leu Gly Ser Ala Pro Arg Ser Pro Ala Pro Arg Glu Gly Pro Pro Pro 
    50                  55                  60                  


Val Leu Ala Ser Pro Ala Gly His Leu Pro Gly Arg 
65                  70                  75      


<210> 3321
<211> 66
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<400> 3321
Met Glu Leu Gly Leu Gly Gly Leu Ser Xaa Leu Ser His Cys Pro Trp 
1               5                   10                  15      


Pro Arg Gln Gln Pro Ala Leu Trp Pro Xaa Leu Ala Ala Leu Ala Leu 
            20                  25                  30          


Leu Ser Ser Val Ala Glu Ala Ser Leu Gly Ser Ala Pro Arg Ser Pro 
        35                  40                  45              


Ala Pro Arg Glu Gly Pro Pro Pro Val Leu Ala Ser Pro Ala Gly His 
    50                  55                  60                  


Leu Pro 
65      


<210> 3322
<211> 220
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<400> 3322
Met Glu Leu Gly Leu Gly Gly Leu Ser Xaa Leu Ser His Cys Pro Trp 
1               5                   10                  15      


Pro Arg Gln Gln Pro Ala Leu Trp Pro Xaa Leu Ala Ala Leu Ala Leu 
            20                  25                  30          


Leu Ser Ser Val Ala Glu Ala Ser Leu Gly Ser Ala Pro Arg Ser Pro 
        35                  40                  45              


Ala Pro Arg Glu Gly Pro Pro Pro Val Leu Ala Ser Pro Ala Gly His 
    50                  55                  60                  


Leu Pro Gly Gly Arg Xaa Ala Arg Trp Cys Ser Gly Arg Ala Arg Arg 
65                  70                  75                  80  


Pro Pro Pro Gln Pro Ser Arg Pro Ala Pro Pro Pro Pro Ala Pro Pro 
                85                  90                  95      


Ser Ala Leu Pro Arg Gly Gly Arg Ala Ala Arg Ala Gly Gly Pro Gly 
            100                 105                 110         


Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys Arg Leu Arg Ser Gln 
        115                 120                 125             


Leu Val Pro Val Arg Ala Leu Gly Leu Gly His Arg Ser Asp Glu Leu 
    130                 135                 140                 


Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg Arg Ala Arg Ser Pro 
145                 150                 155                 160 


His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala Gly Ala Leu Arg Pro 
                165                 170                 175     


Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys Cys Arg Pro Xaa Arg 
            180                 185                 190         


Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser Xaa Trp Arg Xaa Val 
        195                 200                 205             


Asp Arg Leu Ser Ala Xaa Ala Cys Gly Cys Leu Gly 
    210                 215                 220 


<210> 3323
<211> 237
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<400> 3323
Met Pro Gly Leu Ile Ser Ala Arg Gly Gln Pro Leu Leu Glu Val Leu 
1               5                   10                  15      


Pro Pro Gln Ala His Leu Gly Ala Leu Phe Leu Pro Glu Ala Pro Leu 
            20                  25                  30          


Gly Leu Ser Ala Gln Pro Ala Leu Trp Pro Xaa Leu Ala Ala Leu Ala 
        35                  40                  45              


Leu Leu Ser Ser Val Ala Glu Ala Ser Leu Gly Ser Ala Pro Arg Ser 
    50                  55                  60                  


Pro Ala Pro Arg Glu Gly Pro Pro Pro Val Leu Ala Ser Pro Ala Gly 
65                  70                  75                  80  


His Leu Pro Gly Gly Arg Xaa Ala Arg Trp Cys Ser Gly Arg Ala Arg 
                85                  90                  95      


Arg Pro Pro Pro Gln Pro Ser Arg Pro Ala Pro Pro Pro Pro Ala Pro 
            100                 105                 110         


Pro Ser Ala Leu Pro Arg Gly Gly Arg Ala Ala Arg Ala Gly Gly Pro 
        115                 120                 125             


Gly Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys Arg Leu Arg Ser 
    130                 135                 140                 


Gln Leu Val Pro Val Arg Ala Leu Gly Leu Gly His Arg Ser Asp Glu 
145                 150                 155                 160 


Leu Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg Arg Ala Arg Ser 
                165                 170                 175     


Pro His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala Gly Ala Leu Arg 
            180                 185                 190         


Pro Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys Cys Arg Pro Xaa 
        195                 200                 205             


Arg Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser Xaa Trp Arg Xaa 
    210                 215                 220                 


Val Asp Arg Leu Ser Ala Xaa Ala Cys Gly Cys Leu Gly 
225                 230                 235         


<210> 3324
<211> 562
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<400> 3324
Met Ser Asn Gln Tyr Gln Glu Glu Gly Cys Ser Glu Arg Pro Glu Cys 
1               5                   10                  15      


Lys Ser Lys Ser Pro Xaa Leu Leu Ser Ser Tyr Cys Ile Asp Ser Ile 
            20                  25                  30          


Leu Gly Arg Arg Ser Pro Cys Lys Met Arg Leu Leu Gly Ala Ala Gln 
        35                  40                  45              


Ser Leu Pro Ala Pro Leu Xaa Ser Arg Ala Asp Pro Glu Lys Ala Val 
    50                  55                  60                  


Gln Gly Ser Pro Lys Ser Ser Ser Ala Pro Phe Glu Ala Glu Leu His 
65                  70                  75                  80  


Leu Pro Pro Lys Leu Arg Arg Leu Tyr Gly Pro Gly Gly Gly Arg Leu 
                85                  90                  95      


Leu Gln Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            100                 105                 110         


Ala Ala Ala Xaa Ala Xaa Ala Gly Pro Arg Gly Glu Ala Pro Pro Pro 
        115                 120                 125             


Pro Pro Pro Xaa Ala Arg Pro Gly Glu Arg Pro Asp Gly Ala Gly Ala 
    130                 135                 140                 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Trp Asp Xaa Leu Lys 
145                 150                 155                 160 


Ile Ser Gln Ala Pro Gln Val Ser Ile Ser Arg Ser Lys Ser Tyr Arg 
                165                 170                 175     


Glu Asn Gly Ala Pro Phe Val Pro Pro Pro Pro Ala Leu Asp Glu Leu 
            180                 185                 190         


Gly Gly Pro Gly Gly Val Xaa His Pro Glu Glu Arg Leu Gly Val Ala 
        195                 200                 205             


Gly Gly Pro Gly Ser Ala Pro Ala Ala Gly Gly Gly Xaa Gly Xaa Glu 
    210                 215                 220                 


Asp Asp Glu Glu Glu Leu Leu Glu Asp Glu Glu Asp Glu Asp Glu Glu 
225                 230                 235                 240 


Glu Glu Leu Leu Glu Asp Asp Glu Glu Glu Leu Leu Glu Asp Asp Ala 
                245                 250                 255     


Arg Ala Leu Leu Lys Glu Pro Arg Arg Cys Pro Val Ala Ala Xaa Gly 
            260                 265                 270         


Ala Val Ala Ala Ala Ala Ala Ala Ala Val Ala Xaa Glu Gly Gly Glu 
        275                 280                 285             


Leu Ser Pro Lys Glu Glu Leu Leu Leu His Pro Glu Asp Ala Glu Gly 
    290                 295                 300                 


Lys Asp Gly Glu Asp Ser Val Cys Leu Ser Ala Gly Ser Asp Ser Glu 
305                 310                 315                 320 


Glu Gly Leu Leu Lys Arg Lys Gln Arg Arg Tyr Arg Xaa Xaa Phe Xaa 
                325                 330                 335     


Ser Tyr Gln Leu Glu Glu Leu Glu Arg Ala Phe Gln Lys Xaa His Tyr 
            340                 345                 350         


Pro Asp Val Phe Xaa Arg Glu Glu Leu Ala Met Arg Leu Asp Leu Xaa 
        355                 360                 365             


Glu Ala Arg Val Gln Val Trp Phe Gln Asn Arg Arg Ala Lys Trp Arg 
    370                 375                 380                 


Lys Arg Glu Lys Ala Gly Ala Gln Xaa His Pro Pro Gly Leu Pro Phe 
385                 390                 395                 400 


Pro Gly Pro Leu Ser Ala Xaa His Pro Leu Ser Pro Tyr Leu Asp Ala 
                405                 410                 415     


Ser Pro Phe Pro Pro His His Pro Ala Leu Asp Ser Ala Trp Xaa Ala 
            420                 425                 430         


Ala Ala Ala Ala Ala Ala Ala Ala Phe Pro Ser Leu Pro Pro Pro Pro 
        435                 440                 445             


Gly Ser Ala Ser Leu Pro Pro Ser Gly Ala Pro Leu Gly Leu Ser Xaa 
    450                 455                 460                 


Phe Leu Gly Ala Ala Val Phe Arg His Pro Ala Phe Ile Ser Pro Ala 
465                 470                 475                 480 


Phe Gly Arg Leu Phe Ser Xaa Met Ala Pro Leu Xaa Ser Ala Ser Xaa 
                485                 490                 495     


Ala Ala Ala Leu Leu Arg Gln Pro Xaa Pro Ala Val Glu Gly Ala Val 
            500                 505                 510         


Ala Ser Gly Ala Leu Ala Asp Pro Ala Xaa Ala Ala Ala Asp Arg Arg 
        515                 520                 525             


Ala Ser Ser Ile Ala Ala Leu Arg Leu Lys Ala Lys Glu His Ala Ala 
    530                 535                 540                 


Gln Leu Xaa Gln Leu Asn Ile Leu Pro Gly Xaa Ser Xaa Gly Lys Glu 
545                 550                 555                 560 


Val Cys 
        


<210> 3325
<211> 48
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<400> 3325
Xaa Xaa Phe Leu Gly Ala Ala Val Phe Arg His Pro Ala Phe Ile Ser 
1               5                   10                  15      


Pro Ala Phe Gly Arg Leu His Leu Pro Cys His Ser Ser Asp Pro Leu 
            20                  25                  30          


Pro Xaa Xaa Pro Pro Tyr Val Gln Ala Pro Ile Tyr Xaa Ala Val Gln 
        35                  40                  45              


<210> 3326
<211> 51
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<400> 3326
Ala Gln Arg Tyr Glu Ala Ala Ser Xaa Ile Tyr Gly Pro His Xaa Leu 
1               5                   10                  15      


Ser Ala Tyr Ile Gln Leu Phe Arg Asn Leu Ala Lys Ala Ile Ala Xaa 
            20                  25                  30          


Glu Leu His Leu Trp Lys Ser Ser Leu Trp Met Gln Leu Phe Met Lys 
        35                  40                  45              


Leu Gln Leu 
    50      


<210> 3327
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<400> 3327
Ala Gln Arg Tyr Glu Ala Ala Ser Xaa Ile Tyr Gly Pro His Xaa Leu 
1               5                   10                  15      


Ser Ala Tyr Ile Gln Leu Phe Arg Asn Leu Ala Lys Ala Ile Ala Xaa 
            20                  25                  30          


Gly Glu Val Ala Glu Val Ile Phe Val Gly Ala Asn Pro Lys Asn Ser 
        35                  40                  45              


Val Gln Asn Gln Xaa His Gln Xaa Phe Leu Xaa Val Glu Lys Tyr Glu 
    50                  55                  60                  


Ala Xaa Ser Xaa Ser Trp Gln Ile Val Cys Asn Asp Ala Ser Trp Glu 
65                  70                  75                  80  


Xaa Arg Phe Tyr Trp His Lys Gly Leu Leu Gly Leu Ser Asn Ala Xaa 
                85                  90                  95      


Val Glu Trp His Ile Pro Asp Xaa Ala Gln Pro Gly Ile Tyr Arg Ile 
            100                 105                 110         


Arg Tyr Phe Gly His Asn Arg Lys Gln Asp Ile Leu Lys Pro Ala Val 
        115                 120                 125             


Ile Leu Ser Phe Glu Gly Xaa Ser Pro Ala Phe Glu Val Val Xaa Ile 
    130                 135                 140                 


<210> 3328
<211> 745
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<400> 3328
Met Ala Lys Arg Xaa Phe Ser Asn Leu Glu Xaa Phe Leu Ile Phe Leu 
1               5                   10                  15      


Leu Val Met Met Ser Ala Ile Xaa Val Ala Leu Leu Ser Leu Leu Phe 
            20                  25                  30          


Ile Xaa Ser Gly Xaa Ile Glu Asn His Lys Asp Leu Gly Gly His Phe 
        35                  40                  45              


Phe Ser Xaa Xaa Gln Ser Pro Pro Ala Xaa Gln Gly Ser Xaa Ala Ala 
    50                  55                  60                  


Gln Arg Ser Xaa Ala Xaa Gln His Ser Xaa Ala Xaa Gln Ser Ser Xaa 
65                  70                  75                  80  


Ala Xaa Gln Xaa Ser Pro Val Pro Leu Xaa Pro Glu Ser Pro Leu Phe 
                85                  90                  95      


Gln Asn Phe Ser Gly Tyr His Ile Gly Val Gly Arg Ala Asp Cys Xaa 
            100                 105                 110         


Gly Gln Val Ala Asp Ile Asn Leu Met Gly Tyr Gly Lys Ser Gly Gln 
        115                 120                 125             


Asn Ala Gln Gly Ile Leu Xaa Arg Leu Tyr Ser Arg Ala Phe Ile Met 
    130                 135                 140                 


Ala Glu Pro Asp Gly Ser Asn Arg Xaa Val Phe Val Ser Ile Asp Ile 
145                 150                 155                 160 


Gly Met Val Ser Gln Arg Leu Arg Leu Glu Val Leu Asn Arg Leu Gln 
                165                 170                 175     


Ser Lys Tyr Gly Ser Leu Tyr Arg Arg Asp Asn Val Ile Leu Ser Gly 
            180                 185                 190         


Xaa His Xaa His Ser Gly Pro Ala Gly Tyr Phe Gln Tyr Xaa Val Phe 
        195                 200                 205             


Val Ile Ala Ser Glu Gly Phe Ser Asn Gln Xaa Phe Gln His Met Val 
    210                 215                 220                 


Xaa Gly Ile Leu Lys Ser Ile Asp Ile Ala His Xaa Asn Met Lys Pro 
225                 230                 235                 240 


Gly Lys Ile Phe Ile Asn Lys Gly Asn Val Asp Gly Val Gln Ile Asn 
                245                 250                 255     


Arg Ser Pro Tyr Ser Tyr Leu Gln Asn Pro Gln Ser Glu Arg Ala Arg 
            260                 265                 270         


Tyr Ser Ser Asn Xaa Asp Lys Glu Met Ile Val Leu Lys Met Val Asp 
        275                 280                 285             


Leu Asn Gly Asp Asp Leu Gly Leu Ile Ser Trp Phe Ala Ile His Pro 
    290                 295                 300                 


Val Ser Met Asn Asn Ser Asn His Leu Val Asn Ser Asp Asn Val Gly 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Leu Glu Gln Glu Lys Asn Lys Gly Tyr Leu Pro 
                325                 330                 335     


Gly Gln Gly Pro Phe Val Ala Ala Phe Ala Ser Ser Asn Leu Gly Asp 
            340                 345                 350         


Val Ser Pro Asn Ile Leu Gly Pro Arg Cys Ile Asn Xaa Gly Glu Ser 
        355                 360                 365             


Cys Asp Asn Ala Asn Ser Xaa Cys Pro Ile Gly Gly Pro Ser Met Cys 
    370                 375                 380                 


Ile Ala Lys Gly Pro Gly Gln Asp Met Phe Asp Ser Xaa Gln Ile Ile 
385                 390                 395                 400 


Gly Arg Ala Met Tyr Gln Arg Ala Lys Ser Lys Xaa Cys Lys Pro Ala 
                405                 410                 415     


Leu Gly Tyr Ser Phe Ala Ala Gly Xaa Ile Asp Gly Val Gly Gly Leu 
            420                 425                 430         


Asn Phe Xaa Gln Gly Lys Xaa Glu Gly Asp Pro Phe Trp Asp Xaa Ile 
        435                 440                 445             


Arg Asp Gln Ile Leu Gly Lys Pro Ser Glu Glu Ile Lys Glu Cys His 
    450                 455                 460                 


Lys Pro Lys Pro Ile Leu Leu His Xaa Gly Glu Leu Ser Lys Pro His 
465                 470                 475                 480 


Pro Trp His Pro Asp Ile Val Asp Val Gln Ile Ile Xaa Leu Gly Ser 
                485                 490                 495     


Leu Ala Ile Xaa Ala Ile Pro Gly Glu Phe Xaa Xaa Met Ser Gly Arg 
            500                 505                 510         


Arg Leu Arg Glu Ala Val Gln Ala Glu Phe Ala Ser His Gly Met Gln 
        515                 520                 525             


Asn Met Xaa Val Val Ile Ser Gly Leu Cys Asn Val Tyr Xaa His Tyr 
    530                 535                 540                 


Ile Xaa Xaa Tyr Glu Glu Tyr Gln Ala Gln Arg Tyr Glu Ala Ala Ser 
545                 550                 555                 560 


Xaa Ile Tyr Gly Pro His Xaa Leu Ser Ala Tyr Ile Gln Leu Phe Arg 
                565                 570                 575     


Asn Leu Ala Lys Ala Ile Ala Xaa Asp Xaa Val Ala Asn Leu Ser Arg 
            580                 585                 590         


Gly Pro Glu Pro Pro Phe Phe Lys Gln Leu Ile Val Pro Leu Ile Pro 
        595                 600                 605             


Ser Ile Val Asp Arg Ala Pro Lys Gly Arg Xaa Phe Gly Asp Val Leu 
    610                 615                 620                 


Gln Pro Ala Lys Pro Glu Tyr Arg Val Gly Glu Val Ala Glu Val Ile 
625                 630                 635                 640 


Phe Val Gly Ala Asn Pro Lys Asn Ser Val Gln Asn Gln Xaa His Gln 
                645                 650                 655     


Xaa Phe Leu Xaa Val Glu Lys Tyr Glu Ala Xaa Ser Xaa Ser Trp Gln 
            660                 665                 670         


Ile Val Cys Asn Asp Ala Ser Trp Glu Xaa Arg Phe Tyr Trp His Lys 
        675                 680                 685             


Gly Leu Leu Gly Leu Ser Asn Ala Xaa Val Glu Trp His Ile Pro Asp 
    690                 695                 700                 


Xaa Ala Gln Pro Gly Ile Tyr Arg Ile Arg Tyr Phe Gly His Asn Arg 
705                 710                 715                 720 


Lys Gln Asp Ile Leu Lys Pro Ala Val Ile Leu Ser Phe Glu Gly Xaa 
                725                 730                 735     


Ser Pro Ala Phe Glu Val Val Xaa Ile 
            740                 745 


<210> 3329
<211> 780
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<400> 3329
Met Ala Lys Arg Xaa Phe Ser Asn Leu Glu Xaa Phe Leu Ile Phe Leu 
1               5                   10                  15      


Leu Val Met Met Ser Ala Ile Xaa Val Ala Leu Leu Ser Leu Leu Phe 
            20                  25                  30          


Ile Xaa Ser Gly Xaa Ile Glu Asn His Lys Asp Leu Gly Gly His Phe 
        35                  40                  45              


Phe Ser Xaa Xaa Gln Ser Pro Pro Ala Xaa Gln Gly Ser Xaa Ala Ala 
    50                  55                  60                  


Gln Arg Ser Xaa Ala Xaa Gln His Ser Xaa Ala Xaa Gln Ser Ser Xaa 
65                  70                  75                  80  


Ala Xaa Gln Xaa Ser Pro Val Pro Leu Xaa Pro Glu Ser Pro Leu Phe 
                85                  90                  95      


Gln Asn Phe Ser Gly Tyr His Ile Gly Val Gly Arg Ala Asp Cys Xaa 
            100                 105                 110         


Gly Gln Val Ala Asp Ile Asn Leu Met Gly Tyr Gly Lys Ser Gly Gln 
        115                 120                 125             


Asn Ala Gln Gly Ile Leu Xaa Arg Leu Tyr Ser Arg Ala Phe Ile Met 
    130                 135                 140                 


Ala Glu Pro Asp Gly Ser Asn Arg Xaa Val Phe Val Ser Ile Asp Ile 
145                 150                 155                 160 


Gly Met Val Ser Gln Arg Leu Arg Leu Glu Val Leu Asn Arg Leu Gln 
                165                 170                 175     


Ser Lys Tyr Gly Ser Leu Tyr Arg Arg Asp Asn Val Ile Leu Ser Gly 
            180                 185                 190         


Xaa His Xaa His Ser Gly Pro Ala Gly Tyr Phe Gln Tyr Xaa Val Phe 
        195                 200                 205             


Val Ile Ala Ser Glu Gly Phe Ser Asn Gln Xaa Phe Gln His Met Val 
    210                 215                 220                 


Xaa Gly Ile Leu Lys Ser Ile Asp Ile Ala His Xaa Asn Met Lys Pro 
225                 230                 235                 240 


Gly Lys Ile Phe Ile Asn Lys Gly Asn Val Asp Gly Val Gln Ile Asn 
                245                 250                 255     


Arg Ser Pro Tyr Ser Tyr Leu Gln Asn Pro Gln Ser Glu Arg Ala Arg 
            260                 265                 270         


Tyr Ser Ser Asn Xaa Asp Lys Glu Met Ile Val Leu Lys Met Val Asp 
        275                 280                 285             


Leu Asn Gly Asp Asp Leu Gly Leu Ile Ser Trp Phe Ala Ile His Pro 
    290                 295                 300                 


Val Ser Met Asn Asn Ser Asn His Leu Val Asn Ser Asp Asn Val Gly 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Leu Glu Gln Glu Lys Asn Lys Gly Tyr Leu Pro 
                325                 330                 335     


Gly Gln Gly Pro Phe Val Ala Ala Phe Ala Ser Ser Asn Leu Gly Asp 
            340                 345                 350         


Val Ser Pro Asn Ile Leu Gly Pro Arg Cys Ile Asn Xaa Gly Glu Ser 
        355                 360                 365             


Cys Asp Asn Ala Asn Ser Xaa Cys Pro Ile Gly Gly Pro Ser Met Cys 
    370                 375                 380                 


Ile Ala Lys Gly Pro Gly Gln Asp Met Phe Asp Ser Xaa Gln Ile Ile 
385                 390                 395                 400 


Gly Arg Ala Met Tyr Gln Arg Ala Lys Glu Leu Tyr Ala Ser Ala Ser 
                405                 410                 415     


Gln Glu Val Xaa Gly Pro Leu Ala Ser Ala His Gln Trp Val Asp Met 
            420                 425                 430         


Xaa Asp Val Xaa Val Trp Leu Asn Ser Xaa His Ala Ser Lys Xaa Cys 
        435                 440                 445             


Lys Pro Ala Leu Gly Tyr Ser Phe Ala Ala Gly Xaa Ile Asp Gly Val 
    450                 455                 460                 


Gly Gly Leu Asn Phe Xaa Gln Gly Lys Xaa Glu Gly Asp Pro Phe Trp 
465                 470                 475                 480 


Asp Xaa Ile Arg Asp Gln Ile Leu Gly Lys Pro Ser Glu Glu Ile Lys 
                485                 490                 495     


Glu Cys His Lys Pro Lys Pro Ile Leu Leu His Xaa Gly Glu Leu Ser 
            500                 505                 510         


Lys Pro His Pro Trp His Pro Asp Ile Val Asp Val Gln Ile Ile Xaa 
        515                 520                 525             


Leu Gly Ser Leu Ala Ile Xaa Ala Ile Pro Gly Glu Phe Xaa Xaa Met 
    530                 535                 540                 


Ser Gly Arg Arg Leu Arg Glu Ala Val Gln Ala Glu Phe Ala Ser His 
545                 550                 555                 560 


Gly Met Gln Asn Met Xaa Val Val Ile Ser Gly Leu Cys Asn Val Tyr 
                565                 570                 575     


Xaa His Tyr Ile Xaa Xaa Tyr Glu Glu Tyr Gln Ala Gln Arg Tyr Glu 
            580                 585                 590         


Ala Ala Ser Xaa Ile Tyr Gly Pro His Xaa Leu Ser Ala Tyr Ile Gln 
        595                 600                 605             


Leu Phe Arg Asn Leu Ala Lys Ala Ile Ala Xaa Asp Xaa Val Ala Asn 
    610                 615                 620                 


Leu Ser Arg Gly Pro Glu Pro Pro Phe Phe Lys Gln Leu Ile Val Pro 
625                 630                 635                 640 


Leu Ile Pro Ser Ile Val Asp Arg Ala Pro Lys Gly Arg Xaa Phe Gly 
                645                 650                 655     


Asp Val Leu Gln Pro Ala Lys Pro Glu Tyr Arg Val Gly Glu Val Ala 
            660                 665                 670         


Glu Val Ile Phe Val Gly Ala Asn Pro Lys Asn Ser Val Gln Asn Gln 
        675                 680                 685             


Xaa His Gln Xaa Phe Leu Xaa Val Glu Lys Tyr Glu Ala Xaa Ser Xaa 
    690                 695                 700                 


Ser Trp Gln Ile Val Cys Asn Asp Ala Ser Trp Glu Xaa Arg Phe Tyr 
705                 710                 715                 720 


Trp His Lys Gly Leu Leu Gly Leu Ser Asn Ala Xaa Val Glu Trp His 
                725                 730                 735     


Ile Pro Asp Xaa Ala Gln Pro Gly Ile Tyr Arg Ile Arg Tyr Phe Gly 
            740                 745                 750         


His Asn Arg Lys Gln Asp Ile Leu Lys Pro Ala Val Ile Leu Ser Phe 
        755                 760                 765             


Glu Gly Xaa Ser Pro Ala Phe Glu Val Val Xaa Ile 
    770                 775                 780 


<210> 3330
<211> 622
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<400> 3330
Met Asp Ser Glu Lys Ser Ser Glu Trp Arg Ser Asp Val Leu Asn Arg 
1               5                   10                  15      


Leu Gln Ser Lys Tyr Gly Ser Leu Tyr Arg Arg Asp Asn Val Ile Leu 
            20                  25                  30          


Ser Gly Xaa His Xaa His Ser Gly Pro Ala Gly Tyr Phe Gln Tyr Xaa 
        35                  40                  45              


Val Phe Val Ile Ala Ser Glu Gly Phe Ser Asn Gln Xaa Phe Gln His 
    50                  55                  60                  


Met Val Xaa Gly Ile Leu Lys Ser Ile Asp Ile Ala His Xaa Asn Met 
65                  70                  75                  80  


Lys Pro Gly Lys Ile Phe Ile Asn Lys Gly Asn Val Asp Gly Val Gln 
                85                  90                  95      


Ile Asn Arg Ser Pro Tyr Ser Tyr Leu Gln Asn Pro Gln Ser Glu Arg 
            100                 105                 110         


Ala Arg Tyr Ser Ser Asn Xaa Asp Lys Glu Met Ile Val Leu Lys Met 
        115                 120                 125             


Val Asp Leu Asn Gly Asp Asp Leu Gly Leu Ile Ser Trp Phe Ala Ile 
    130                 135                 140                 


His Pro Val Ser Met Asn Asn Ser Asn His Leu Val Asn Ser Asp Asn 
145                 150                 155                 160 


Val Gly Tyr Ala Ser Tyr Leu Leu Glu Gln Glu Lys Asn Lys Gly Tyr 
                165                 170                 175     


Leu Pro Gly Gln Gly Pro Phe Val Ala Ala Phe Ala Ser Ser Asn Leu 
            180                 185                 190         


Gly Asp Val Ser Pro Asn Ile Leu Gly Pro Arg Cys Ile Asn Xaa Gly 
        195                 200                 205             


Glu Ser Cys Asp Asn Ala Asn Ser Xaa Cys Pro Ile Gly Gly Pro Ser 
    210                 215                 220                 


Met Cys Ile Ala Lys Gly Pro Gly Gln Asp Met Phe Asp Ser Xaa Gln 
225                 230                 235                 240 


Ile Ile Gly Arg Ala Met Tyr Gln Arg Ala Lys Glu Leu Tyr Ala Ser 
                245                 250                 255     


Ala Ser Gln Glu Val Xaa Gly Pro Leu Ala Ser Ala His Gln Trp Val 
            260                 265                 270         


Asp Met Xaa Asp Val Xaa Val Trp Leu Asn Ser Xaa His Ala Ser Lys 
        275                 280                 285             


Xaa Cys Lys Pro Ala Leu Gly Tyr Ser Phe Ala Ala Gly Xaa Ile Asp 
    290                 295                 300                 


Gly Val Gly Gly Leu Asn Phe Xaa Gln Gly Lys Xaa Glu Gly Asp Pro 
305                 310                 315                 320 


Phe Trp Asp Xaa Ile Arg Asp Gln Ile Leu Gly Lys Pro Ser Glu Glu 
                325                 330                 335     


Ile Lys Glu Cys His Lys Pro Lys Pro Ile Leu Leu His Xaa Gly Glu 
            340                 345                 350         


Leu Ser Lys Pro His Pro Trp His Pro Asp Ile Val Asp Val Gln Ile 
        355                 360                 365             


Ile Xaa Leu Gly Ser Leu Ala Ile Xaa Ala Ile Pro Gly Glu Phe Xaa 
    370                 375                 380                 


Xaa Met Ser Gly Arg Arg Leu Arg Glu Ala Val Gln Ala Glu Phe Ala 
385                 390                 395                 400 


Ser His Gly Met Gln Asn Met Xaa Val Val Ile Ser Gly Leu Cys Asn 
                405                 410                 415     


Val Tyr Xaa His Tyr Ile Xaa Xaa Tyr Glu Glu Tyr Gln Ala Gln Arg 
            420                 425                 430         


Tyr Glu Ala Ala Ser Xaa Ile Tyr Gly Pro His Xaa Leu Ser Ala Tyr 
        435                 440                 445             


Ile Gln Leu Phe Arg Asn Leu Ala Lys Ala Ile Ala Xaa Asp Xaa Val 
    450                 455                 460                 


Ala Asn Leu Ser Arg Gly Pro Glu Pro Pro Phe Phe Lys Gln Leu Ile 
465                 470                 475                 480 


Val Pro Leu Ile Pro Ser Ile Val Asp Arg Ala Pro Lys Gly Arg Xaa 
                485                 490                 495     


Phe Gly Asp Val Leu Gln Pro Ala Lys Pro Glu Tyr Arg Val Gly Glu 
            500                 505                 510         


Val Ala Glu Val Ile Phe Val Gly Ala Asn Pro Lys Asn Ser Val Gln 
        515                 520                 525             


Asn Gln Xaa His Gln Xaa Phe Leu Xaa Val Glu Lys Tyr Glu Ala Xaa 
    530                 535                 540                 


Ser Xaa Ser Trp Gln Ile Val Cys Asn Asp Ala Ser Trp Glu Xaa Arg 
545                 550                 555                 560 


Phe Tyr Trp His Lys Gly Leu Leu Gly Leu Ser Asn Ala Xaa Val Glu 
                565                 570                 575     


Trp His Ile Pro Asp Xaa Ala Gln Pro Gly Ile Tyr Arg Ile Arg Tyr 
            580                 585                 590         


Phe Gly His Asn Arg Lys Gln Asp Ile Leu Lys Pro Ala Val Ile Leu 
        595                 600                 605             


Ser Phe Glu Gly Xaa Ser Pro Ala Phe Glu Val Val Xaa Ile 
    610                 615                 620         


<210> 3331
<211> 726
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<400> 3331
Met Ser Ala Ile Xaa Val Ala Leu Leu Ser Leu Leu Phe Ile Xaa Ser 
1               5                   10                  15      


Gly Xaa Ile Glu Asn His Lys Asp Leu Gly Gly His Phe Phe Ser Xaa 
            20                  25                  30          


Xaa Gln Ser Pro Pro Ala Xaa Gln Gly Ser Xaa Ala Ala Gln Arg Ser 
        35                  40                  45              


Xaa Ala Xaa Gln His Ser Xaa Ala Xaa Gln Ser Ser Xaa Ala Xaa Gln 
    50                  55                  60                  


Xaa Ser Pro Val Pro Leu Xaa Pro Glu Ser Pro Leu Phe Gln Asn Phe 
65                  70                  75                  80  


Ser Gly Tyr His Ile Gly Val Gly Arg Ala Asp Cys Xaa Gly Gln Val 
                85                  90                  95      


Ala Asp Ile Asn Leu Met Gly Tyr Gly Lys Ser Gly Gln Asn Ala Gln 
            100                 105                 110         


Gly Ile Leu Xaa Arg Leu Tyr Ser Arg Ala Phe Ile Met Ala Glu Pro 
        115                 120                 125             


Asp Gly Ser Asn Arg Xaa Val Phe Val Ser Ile Asp Ile Gly Met Val 
    130                 135                 140                 


Ser Gln Arg Leu Arg Leu Glu Val Leu Asn Arg Leu Gln Ser Lys Tyr 
145                 150                 155                 160 


Gly Ser Leu Tyr Arg Arg Asp Asn Val Ile Leu Ser Gly Xaa His Xaa 
                165                 170                 175     


His Ser Gly Pro Ala Gly Tyr Phe Gln Tyr Xaa Val Phe Val Ile Ala 
            180                 185                 190         


Ser Glu Gly Phe Ser Asn Gln Xaa Phe Gln His Met Val Xaa Gly Ile 
        195                 200                 205             


Leu Lys Ser Ile Asp Ile Ala His Xaa Asn Met Lys Pro Gly Lys Ile 
    210                 215                 220                 


Phe Ile Asn Lys Gly Asn Val Asp Gly Val Gln Ile Asn Arg Ser Pro 
225                 230                 235                 240 


Tyr Ser Tyr Leu Gln Asn Pro Gln Ser Glu Arg Ala Arg Tyr Ser Ser 
                245                 250                 255     


Asn Xaa Asp Lys Glu Met Ile Val Leu Lys Met Val Asp Leu Asn Gly 
            260                 265                 270         


Asp Asp Leu Gly Leu Ile Ser Trp Phe Ala Ile His Pro Val Ser Met 
        275                 280                 285             


Asn Asn Ser Asn His Leu Val Asn Ser Asp Asn Val Gly Tyr Ala Ser 
    290                 295                 300                 


Tyr Leu Leu Glu Gln Glu Lys Asn Lys Gly Tyr Leu Pro Gly Gln Gly 
305                 310                 315                 320 


Pro Phe Val Ala Ala Phe Ala Ser Ser Asn Leu Gly Asp Val Ser Pro 
                325                 330                 335     


Asn Ile Leu Gly Pro Arg Cys Ile Asn Xaa Gly Glu Ser Cys Asp Asn 
            340                 345                 350         


Ala Asn Ser Xaa Cys Pro Ile Gly Gly Pro Ser Met Cys Ile Ala Lys 
        355                 360                 365             


Gly Pro Gly Gln Asp Met Phe Asp Ser Xaa Gln Ile Ile Gly Arg Ala 
    370                 375                 380                 


Met Tyr Gln Arg Ala Lys Ser Lys Xaa Cys Lys Pro Ala Leu Gly Tyr 
385                 390                 395                 400 


Ser Phe Ala Ala Gly Xaa Ile Asp Gly Val Gly Gly Leu Asn Phe Xaa 
                405                 410                 415     


Gln Gly Lys Xaa Glu Gly Asp Pro Phe Trp Asp Xaa Ile Arg Asp Gln 
            420                 425                 430         


Ile Leu Gly Lys Pro Ser Glu Glu Ile Lys Glu Cys His Lys Pro Lys 
        435                 440                 445             


Pro Ile Leu Leu His Xaa Gly Glu Leu Ser Lys Pro His Pro Trp His 
    450                 455                 460                 


Pro Asp Ile Val Asp Val Gln Ile Ile Xaa Leu Gly Ser Leu Ala Ile 
465                 470                 475                 480 


Xaa Ala Ile Pro Gly Glu Phe Xaa Xaa Met Ser Gly Arg Arg Leu Arg 
                485                 490                 495     


Glu Ala Val Gln Ala Glu Phe Ala Ser His Gly Met Gln Asn Met Xaa 
            500                 505                 510         


Val Val Ile Ser Gly Leu Cys Asn Val Tyr Xaa His Tyr Ile Xaa Xaa 
        515                 520                 525             


Tyr Glu Glu Tyr Gln Ala Gln Arg Tyr Glu Ala Ala Ser Xaa Ile Tyr 
    530                 535                 540                 


Gly Pro His Xaa Leu Ser Ala Tyr Ile Gln Leu Phe Arg Asn Leu Ala 
545                 550                 555                 560 


Lys Ala Ile Ala Xaa Asp Xaa Val Ala Asn Leu Ser Arg Gly Pro Glu 
                565                 570                 575     


Pro Pro Phe Phe Lys Gln Leu Ile Val Pro Leu Ile Pro Ser Ile Val 
            580                 585                 590         


Asp Arg Ala Pro Lys Gly Arg Xaa Phe Gly Asp Val Leu Gln Pro Ala 
        595                 600                 605             


Lys Pro Glu Tyr Arg Val Gly Glu Val Ala Glu Val Ile Phe Val Gly 
    610                 615                 620                 


Ala Asn Pro Lys Asn Ser Val Gln Asn Gln Xaa His Gln Xaa Phe Leu 
625                 630                 635                 640 


Xaa Val Glu Lys Tyr Glu Ala Xaa Ser Xaa Ser Trp Gln Ile Val Cys 
                645                 650                 655     


Asn Asp Ala Ser Trp Glu Xaa Arg Phe Tyr Trp His Lys Gly Leu Leu 
            660                 665                 670         


Gly Leu Ser Asn Ala Xaa Val Glu Trp His Ile Pro Asp Xaa Ala Gln 
        675                 680                 685             


Pro Gly Ile Tyr Arg Ile Arg Tyr Phe Gly His Asn Arg Lys Gln Asp 
    690                 695                 700                 


Ile Leu Lys Pro Ala Val Ile Leu Ser Phe Glu Gly Xaa Ser Pro Ala 
705                 710                 715                 720 


Phe Glu Val Val Xaa Ile 
                725     


<210> 3332
<211> 61
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<400> 3332
Met Ala Glu Gly Gly Ser Pro Asp Gly Arg Ala Gly Pro Gly Ser Ala 
1               5                   10                  15      


Ala Ala Ser Xaa Arg Ser Leu Ser Gly Ala Val Ala Gly Ser Pro Ala 
            20                  25                  30          


His Arg Cys Glu Ser Arg Pro Leu Gln Ala Met Gly Ala Val Trp Xaa 
        35                  40                  45              


Ser Ser Ser Gly Arg Gly Pro Arg Trp Ile Trp Trp Xaa 
    50                  55                  60      


<210> 3333
<211> 234
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<400> 3333
Met Ala Glu Gly Gly Ser Pro Asp Gly Arg Ala Gly Pro Gly Ser Ala 
1               5                   10                  15      


Gly Arg Asn Leu Lys Glu Trp Leu Arg Glu Gln Phe Cys Asp His Pro 
            20                  25                  30          


Leu Glu His Cys Glu Asp Xaa Arg Leu His Asp Ala Ala Tyr Val Gly 
        35                  40                  45              


Asp Leu Gln Xaa Leu Arg Ser Leu Leu Gln Glu Glu Ser Tyr Arg Arg 
    50                  55                  60                  


Tyr Gly Ala Asp Val Asp Val Asn His His Leu Xaa Pro Asp Val Gln 
65                  70                  75                  80  


Pro Arg Phe Ser Arg Arg Leu Xaa Ser Leu Val Val Cys Pro Leu Tyr 
                85                  90                  95      


Ile Ser Ala Ala Tyr His Asn Leu Gln Cys Phe Arg Leu Leu Leu Leu 
            100                 105                 110         


Ala Gly Ala Asn Pro Asp Phe Asn Cys Asn Gly Pro Val Asn Xaa Gln 
        115                 120                 125             


Gly Phe Tyr Arg Gly Ser Pro Gly Cys Val Met Asp Ala Val Leu Arg 
    130                 135                 140                 


His Gly Cys Glu Ala Ala Phe Val Ser Leu Leu Val Glu Phe Gly Ala 
145                 150                 155                 160 


Asn Leu Asn Leu Val Lys Trp Glu Ser Leu Gly Pro Glu Ser Arg Gly 
                165                 170                 175     


Arg Arg Lys Val Asp Pro Glu Ala Leu Gln Val Phe Lys Glu Ala Arg 
            180                 185                 190         


Ser Val Pro Arg Xaa Leu Leu Cys Leu Cys Arg Val Ala Val Arg Arg 
        195                 200                 205             


Ala Leu Gly Lys His Arg Leu His Leu Ile Pro Ser Leu Pro Leu Pro 
    210                 215                 220                 


Asp Pro Ile Lys Lys Phe Leu Leu His Glu 
225                 230                 


<210> 3334
<211> 335
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<400> 3334
Met Ala Glu Gly Gly Ser Pro Asp Gly Arg Ala Gly Pro Gly Ser Ala 
1               5                   10                  15      


Gly Arg Asn Leu Lys Glu Trp Leu Arg Glu Gln Phe Cys Asp His Pro 
            20                  25                  30          


Leu Glu His Cys Glu Asp Xaa Arg Leu His Asp Ala Ala Tyr Val Gly 
        35                  40                  45              


Asp Leu Gln Xaa Leu Arg Ser Leu Leu Gln Glu Glu Ser Tyr Arg Ser 
    50                  55                  60                  


Arg Ile Asn Glu Lys Ser Val Trp Cys Cys Gly Trp Leu Pro Cys Xaa 
65                  70                  75                  80  


Pro Leu Arg Ile Ala Ala Xaa Ala Gly His Gly Ser Cys Val Asp Phe 
                85                  90                  95      


Leu Ile Arg Lys Gly Ala Glu Val Asp Leu Val Asp Val Lys Gly Gln 
            100                 105                 110         


Xaa Ala Leu Tyr Val Ala Val Val Asn Gly His Leu Glu Ser Xaa Gln 
        115                 120                 125             


Ile Leu Leu Glu Ala Gly Ala Asp Pro Asn Gly Ser Arg His His Arg 
    130                 135                 140                 


Ser Xaa Pro Val Tyr His Ala Ser Arg Val Gly Arg Ala Asp Ile Leu 
145                 150                 155                 160 


Lys Ala Leu Ile Arg Tyr Gly Ala Asp Val Asp Val Asn His His Leu 
                165                 170                 175     


Xaa Pro Asp Val Gln Pro Arg Phe Ser Arg Arg Leu Xaa Ser Leu Val 
            180                 185                 190         


Val Cys Pro Leu Tyr Ile Ser Ala Ala Tyr His Asn Leu Gln Cys Phe 
        195                 200                 205             


Arg Leu Leu Leu Leu Ala Gly Ala Asn Pro Asp Phe Asn Cys Asn Gly 
    210                 215                 220                 


Pro Val Asn Xaa Gln Gly Phe Tyr Arg Gly Ser Pro Gly Cys Val Met 
225                 230                 235                 240 


Asp Ala Val Leu Arg His Gly Cys Glu Ala Ala Phe Val Ser Leu Leu 
                245                 250                 255     


Val Glu Phe Gly Ala Asn Leu Asn Leu Val Lys Trp Glu Ser Leu Gly 
            260                 265                 270         


Pro Glu Ser Arg Gly Arg Arg Lys Val Asp Pro Glu Ala Leu Gln Val 
        275                 280                 285             


Phe Lys Glu Ala Arg Ser Val Pro Arg Xaa Leu Leu Cys Leu Cys Arg 
    290                 295                 300                 


Val Ala Val Arg Arg Ala Leu Gly Lys His Arg Leu His Leu Ile Pro 
305                 310                 315                 320 


Ser Leu Pro Leu Pro Asp Pro Ile Lys Lys Phe Leu Leu His Glu 
                325                 330                 335 


<210> 3335
<211> 429
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<400> 3335
Met Leu Met Ser Trp Ser Pro Glu Glu Cys Lys Gly Gln Gly Glu Pro 
1               5                   10                  15      


Leu Asp Asp Arg His Pro Leu Cys Ala Arg Leu Val Glu Lys Pro Ser 
            20                  25                  30          


Arg Gly Ser Glu Glu His Leu Lys Ser Gly Pro Gly Pro Ile Val Xaa 
        35                  40                  45              


Arg Xaa Ala Ser Gly Pro Ala Leu Ala Phe Trp Gln Ala Val Leu Ala 
    50                  55                  60                  


Gly Asp Val Gly Cys Val Ser Arg Ile Leu Ala Asp Ser Ser Xaa Gly 
65                  70                  75                  80  


Leu Ala Pro Asp Ser Val Phe Asp Xaa Ser Asp Pro Glu Arg Trp Arg 
                85                  90                  95      


Asp Phe Arg Phe Asn Ile Arg Ala Leu Arg Leu Trp Ser Leu Xaa Tyr 
            100                 105                 110         


Glu Glu Glu Leu Xaa Xaa Pro Leu His Val Ala Ala Ser Arg Gly His 
        115                 120                 125             


Xaa Glu Val Leu Arg Leu Leu Leu Arg Arg Arg Ala Arg Pro Asp Ser 
    130                 135                 140                 


Ala Pro Gly Gly Arg Xaa Ala Leu His Glu Ala Cys Ala Ala Gly His 
145                 150                 155                 160 


Xaa Ala Cys Val His Val Leu Leu Val Ala Gly Ala Asp Pro Asn Ile 
                165                 170                 175     


Ala Asp Gln Asp Gly Lys Arg Pro Leu His Leu Cys Arg Gly Pro Gly 
            180                 185                 190         


Xaa Leu Glu Cys Ala Glu Leu Leu Leu Arg Phe Gly Ala Arg Val Asp 
        195                 200                 205             


Gly Arg Ser Glu Glu Glu Glu Glu Xaa Pro Leu His Val Ala Ala Arg 
    210                 215                 220                 


Leu Gly His Val Glu Leu Ala Asp Leu Leu Leu Arg Arg Gly Ala Cys 
225                 230                 235                 240 


Pro Asp Ala Arg Asn Ala Glu Gly Trp Xaa Pro Leu Leu Ala Ala Cys 
                245                 250                 255     


Asp Val Arg Cys Gln Ser Ile Xaa Asp Ala Glu Ala Xaa Xaa Ala Arg 
            260                 265                 270         


Cys Leu Gln Leu Cys Ser Leu Leu Leu Ser Ala Gly Ala Asp Ala Asp 
        275                 280                 285             


Ala Ala Asp Gln Asp Lys Gln Arg Pro Leu His Leu Ala Cys Arg Arg 
    290                 295                 300                 


Gly His Ala Ala Val Val Glu Leu Leu Leu Ser Cys Gly Val Ser Ala 
305                 310                 315                 320 


Asn Xaa Met Asp Tyr Gly Gly His Xaa Pro Leu His Cys Ala Leu Gln 
                325                 330                 335     


Gly Pro Ala Ala Ala Leu Ala Gln Ser Pro Glu His Val Val Arg Ala 
            340                 345                 350         


Leu Leu Asn His Gly Ala Val Arg Val Trp Pro Gly Ala Leu Pro Lys 
        355                 360                 365             


Lys His Gln Arg Phe Tyr Ser Ser Leu Phe Ala Leu Val Arg Gln Pro 
    370                 375                 380                 


Arg Ser Leu Gln His Leu Ser Arg Cys Ala Leu Arg Ser His Leu Glu 
385                 390                 395                 400 


Gly Ser Leu Pro Gln Ala Leu Pro Arg Leu Pro Leu Pro Pro Arg Leu 
                405                 410                 415     


Leu Arg Tyr Leu Gln Leu Asp Phe Glu Gly Val Leu Tyr 
            420                 425                 


<210> 3336
<211> 467
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<400> 3336
Met Leu Met Ser Trp Ser Pro Glu Glu Cys Lys Gly Gln Gly Glu Pro 
1               5                   10                  15      


Leu Asp Asp Arg His Pro Leu Cys Ala Arg Leu Val Glu Lys Pro Ser 
            20                  25                  30          


Arg Gly Ser Glu Glu His Leu Lys Ser Gly Pro Gly Pro Ile Val Xaa 
        35                  40                  45              


Arg Xaa Ala Ser Gly Pro Ala Leu Ala Phe Trp Gln Ala Val Leu Ala 
    50                  55                  60                  


Gly Asp Val Gly Cys Val Ser Arg Ile Leu Ala Asp Ser Ser Xaa Gly 
65                  70                  75                  80  


Leu Ala Pro Asp Ser Val Phe Asp Xaa Ser Asp Pro Glu Arg Trp Arg 
                85                  90                  95      


Asp Phe Arg Phe Asn Ile Arg Ala Leu Arg Leu Trp Ser Leu Xaa Tyr 
            100                 105                 110         


Glu Glu Glu Leu Xaa Xaa Pro Leu His Val Ala Ala Ser Arg Gly His 
        115                 120                 125             


Xaa Glu Val Leu Arg Leu Leu Leu Arg Arg Arg Ala Arg Pro Asp Ser 
    130                 135                 140                 


Ala Pro Gly Gly Arg Xaa Ala Leu His Glu Ala Cys Ala Ala Gly His 
145                 150                 155                 160 


Xaa Ala Cys Val His Val Leu Leu Val Ala Gly Ala Asp Pro Asn Ile 
                165                 170                 175     


Ala Asp Gln Asp Gly Lys Arg Pro Leu His Leu Cys Arg Gly Pro Gly 
            180                 185                 190         


Xaa Leu Glu Cys Ala Glu Leu Leu Leu Arg Phe Gly Ala Arg Val Asp 
        195                 200                 205             


Gly Arg Ser Glu Glu Glu Glu Glu Xaa Pro Leu His Val Ala Ala Arg 
    210                 215                 220                 


Leu Gly His Val Glu Leu Ala Asp Leu Leu Leu Arg Arg Gly Ala Cys 
225                 230                 235                 240 


Pro Asp Ala Arg Asn Ala Glu Gly Trp Xaa Pro Leu Leu Ala Ala Cys 
                245                 250                 255     


Asp Val Arg Cys Gln Ser Ile Xaa Asp Ala Glu Ala Xaa Xaa Ala Arg 
            260                 265                 270         


Cys Leu Gln Leu Cys Ser Leu Leu Leu Ser Ala Gly Ala Asp Ala Asp 
        275                 280                 285             


Ala Ala Asp Gln Asp Lys Gln Arg Pro Leu His Leu Ala Cys Arg Arg 
    290                 295                 300                 


Gly His Ala Ala Val Val Glu Leu Leu Leu Ser Cys Gly Val Ser Ala 
305                 310                 315                 320 


Asn Xaa Met Asp Tyr Gly Gly His Xaa Pro Leu His Cys Ala Leu Gln 
                325                 330                 335     


Gly Pro Ala Ala Ala Leu Ala Gln Ser Pro Glu His Val Val Arg Ala 
            340                 345                 350         


Leu Leu Asn His Gly Ala Val Arg Val Trp Pro Gly Ala Leu Pro Lys 
        355                 360                 365             


Val Leu Glu Arg Trp Ser Xaa Cys Pro Arg Xaa Ile Glu Val Leu Met 
    370                 375                 380                 


Asn Xaa Tyr Ser Val Val Gln Leu Pro Glu Glu Ala Val Gly Leu Val 
385                 390                 395                 400 


Xaa Pro Glu Xaa Leu Gln Lys His Gln Arg Phe Tyr Ser Ser Leu Phe 
                405                 410                 415     


Ala Leu Val Arg Gln Pro Arg Ser Leu Gln His Leu Ser Arg Cys Ala 
            420                 425                 430         


Leu Arg Ser His Leu Glu Gly Ser Leu Pro Gln Ala Leu Pro Arg Leu 
        435                 440                 445             


Pro Leu Pro Pro Arg Leu Leu Arg Tyr Leu Gln Leu Asp Phe Glu Gly 
    450                 455                 460                 


Val Leu Tyr 
465         


<210> 3337
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 3337
Met Pro Trp Gly Lys Asn Ser Ser Pro His Trp Gly His His Leu Gly 
1               5                   10                  15      


Cys Leu Pro Ser Ala Pro Ala Cys Arg Ile Trp Arg Pro His Ser Arg 
            20                  25                  30          


Pro Ala Trp Glu Pro Pro Arg Pro Ser Pro Leu Leu Cys Gln Asp Met 
        35                  40                  45              


Ala Leu Gln Asn Ala Leu Tyr Xaa Gly Asp Leu Ala Arg Leu Gln Glu 
    50                  55                  60                  


Leu Phe Pro Pro His Ser Xaa Ala Asp Leu Leu Leu Glu Ser Arg Ala 
65                  70                  75                  80  


Ala Glu Pro Arg Trp Ser Ser His Gln Arg Gly Glu Gly His Leu Gly 
                85                  90                  95      


Val Ala Glu Asn Gln Gly Ala Gly Leu Xaa Ala Ser Ala Xaa Glu Val 
            100                 105                 110         


Leu Arg Ala 
        115 


<210> 3338
<211> 452
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<400> 3338
Met Pro Trp Gly Lys Asn Ser Ser Pro His Trp Gly His His Leu Gly 
1               5                   10                  15      


Cys Leu Pro Ser Ala Pro Ala Cys Arg Ile Trp Arg Pro His Ser Arg 
            20                  25                  30          


Pro Ala Trp Glu Pro Pro Arg Pro Ser Pro Leu Leu Cys Gln Asp Met 
        35                  40                  45              


Ala Leu Gln Asn Ala Leu Tyr Xaa Gly Asp Leu Ala Arg Leu Gln Glu 
    50                  55                  60                  


Leu Phe Pro Pro His Ser Xaa Ala Asp Leu Leu Leu Glu Ser Arg Ala 
65                  70                  75                  80  


Ala Glu Pro Arg Trp Ser Ser His Gln Arg Gly Leu Trp Ser Leu Xaa 
                85                  90                  95      


Tyr Glu Glu Glu Leu Xaa Xaa Pro Leu His Val Ala Ala Ser Arg Gly 
            100                 105                 110         


His Xaa Glu Val Leu Arg Leu Leu Leu Arg Arg Arg Ala Arg Pro Asp 
        115                 120                 125             


Ser Ala Pro Gly Gly Arg Xaa Ala Leu His Glu Ala Cys Ala Ala Gly 
    130                 135                 140                 


His Xaa Ala Cys Val His Val Leu Leu Val Ala Gly Ala Asp Pro Asn 
145                 150                 155                 160 


Ile Ala Asp Gln Asp Gly Lys Arg Pro Leu His Leu Cys Arg Gly Pro 
                165                 170                 175     


Gly Xaa Leu Glu Cys Ala Glu Leu Leu Leu Arg Phe Gly Ala Arg Val 
            180                 185                 190         


Asp Gly Arg Ser Glu Glu Glu Glu Glu Xaa Pro Leu His Val Ala Ala 
        195                 200                 205             


Arg Leu Gly His Val Glu Leu Ala Asp Leu Leu Leu Arg Arg Gly Ala 
    210                 215                 220                 


Cys Pro Asp Ala Arg Asn Ala Glu Gly Trp Xaa Pro Leu Leu Ala Ala 
225                 230                 235                 240 


Cys Asp Val Arg Cys Gln Ser Ile Xaa Asp Ala Glu Ala Xaa Xaa Ala 
                245                 250                 255     


Arg Cys Leu Gln Leu Cys Ser Leu Leu Leu Ser Ala Gly Ala Asp Ala 
            260                 265                 270         


Asp Ala Ala Asp Gln Asp Lys Gln Arg Pro Leu His Leu Ala Cys Arg 
        275                 280                 285             


Arg Gly His Ala Ala Val Val Glu Leu Leu Leu Ser Cys Gly Val Ser 
    290                 295                 300                 


Ala Asn Xaa Met Asp Tyr Gly Gly His Xaa Pro Leu His Cys Ala Leu 
305                 310                 315                 320 


Gln Gly Pro Ala Ala Ala Leu Ala Gln Ser Pro Glu His Val Val Arg 
                325                 330                 335     


Ala Leu Leu Asn His Gly Ala Val Arg Val Trp Pro Gly Ala Leu Pro 
            340                 345                 350         


Lys Val Leu Glu Arg Trp Ser Xaa Cys Pro Arg Xaa Ile Glu Val Leu 
        355                 360                 365             


Met Asn Xaa Tyr Ser Val Val Gln Leu Pro Glu Glu Ala Val Gly Leu 
    370                 375                 380                 


Val Xaa Pro Glu Xaa Leu Gln Lys His Gln Arg Phe Tyr Ser Ser Leu 
385                 390                 395                 400 


Phe Ala Leu Val Arg Gln Pro Arg Ser Leu Gln His Leu Ser Arg Cys 
                405                 410                 415     


Ala Leu Arg Ser His Leu Glu Gly Ser Leu Pro Gln Ala Leu Pro Arg 
            420                 425                 430         


Leu Pro Leu Pro Pro Arg Leu Leu Arg Tyr Leu Gln Leu Asp Phe Glu 
        435                 440                 445             


Gly Val Leu Tyr 
    450         


<210> 3339
<211> 306
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<400> 3339
Met Glu Asp Gly Pro Val Phe Tyr Gly Phe Lys Asn Ile Phe Ile Xaa 
1               5                   10                  15      


Met Phe Ala Xaa Phe Phe Phe Phe Lys Leu Leu Ile Lys Val Phe Leu 
            20                  25                  30          


Ala Leu Leu Xaa His Phe Tyr Ile Val Lys Gly Asn Arg Lys Glu Ala 
        35                  40                  45              


Ala Arg Ile Ala Glu Glu Ile Tyr Gly Gly Ile Ser Asp Cys Trp Ala 
    50                  55                  60                  


Asp Arg Ser Pro Leu His Glu Ala Ala Ala Gln Gly Arg Leu Leu Ala 
65                  70                  75                  80  


Leu Lys Xaa Leu Ile Ala Gln Ala Cys Leu Gly Gly His Val Ala Cys 
                85                  90                  95      


Ala Lys Ala Leu Leu Glu Asn Gly Ala His Val Asn Gly Val Xaa Val 
            100                 105                 110         


His Gly Ala Xaa Pro Leu Phe Asn Ala Cys Cys Ser Gly Ser Ala Ala 
        115                 120                 125             


Cys Val Asn Val Leu Leu Glu Phe Gly Ala Lys Ala Gln Leu Glu Val 
    130                 135                 140                 


His Leu Ala Ser Pro Ile His Glu Ala Val Lys Arg Gly His Arg Glu 
145                 150                 155                 160 


Cys Met Glu Ile Leu Leu Ala Asn Asn Val Asn Ile Asp His Glu Val 
                165                 170                 175     


Pro Gln Leu Gly Xaa Pro Leu Tyr Val Ala Cys Xaa Tyr Gln Arg Val 
            180                 185                 190         


Asp Cys Val Lys Lys Leu Leu Glu Leu Gly Ala Ser Val Asp His Gly 
        195                 200                 205             


Gln Trp Leu Asp Xaa Pro Leu His Ala Ala Ala Arg Gln Ser Asn Val 
    210                 215                 220                 


Glu Val Ile His Leu Leu Xaa Asp Tyr Gly Ala Asn Leu Lys Arg Arg 
225                 230                 235                 240 


Asn Ala Gln Gly Lys Ser Ala Leu Asp Leu Ala Ala Pro Lys Ser Ser 
                245                 250                 255     


Val Glu Gln Ala Leu Leu Leu Arg Glu Gly Pro Pro Ala Leu Ser Gln 
            260                 265                 270         


Leu Cys Arg Leu Cys Val Arg Lys Cys Leu Gly Arg Ala Cys His Gln 
        275                 280                 285             


Ala Ile His Lys Leu His Leu Pro Glu Pro Leu Glu Arg Phe Leu Leu 
    290                 295                 300                 


Tyr Gln 
305     


<210> 3340
<211> 224
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<400> 3340
Met Glu Asp Gly Pro Val Phe Tyr Gly Phe Lys Asn Ile Phe Ile Xaa 
1               5                   10                  15      


Met Phe Ala Xaa Phe Phe Phe Phe Lys Leu Leu Ile Lys Val Phe Leu 
            20                  25                  30          


Ala Leu Leu Xaa His Phe Tyr Ile Val Lys Gly Asn Arg Lys Glu Ala 
        35                  40                  45              


Ala Arg Ile Ala Glu Glu Ile Tyr Gly Gly Ile Ser Asp Cys Trp Ala 
    50                  55                  60                  


Asp Arg Ser Pro Leu His Glu Ala Ala Ala Gln Gly Arg Leu Leu Ala 
65                  70                  75                  80  


Leu Lys Xaa Leu Ile Ala Gln Gly Val Asn Val Asn Leu Val Xaa Ile 
                85                  90                  95      


Asn Arg Val Ser Ser Leu His Glu Ala Cys Leu Gly Gly His Val Ala 
            100                 105                 110         


Cys Ala Lys Ala Leu Leu Glu Asn Gly Ala His Val Asn Gly Val Xaa 
        115                 120                 125             


Val His Gly Ala Xaa Pro Leu Phe Asn Ala Cys Cys Ser Gly Ser Ala 
    130                 135                 140                 


Ala Cys Val Asn Val Leu Leu Glu Phe Gly Ala Lys Ala Gln Leu Glu 
145                 150                 155                 160 


Val His Leu Ala Ser Pro Ile His Glu Ala Val Lys Arg Glu Ser Arg 
                165                 170                 175     


Ala Val Ala Gln Ala Ala Val Gln Trp His Asp Phe Cys Ser Leu Gln 
            180                 185                 190         


Pro Leu Ala Pro Gly Phe Lys Arg Phe Ser Cys Leu Ser Leu Pro Ser 
        195                 200                 205             


Ser Trp Asp Tyr Arg Ser Gln Arg Val His Gly Asp Pro Ala Gly Lys 
    210                 215                 220                 


<210> 3341
<211> 323
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<400> 3341
Met Glu Asp Gly Pro Val Phe Tyr Gly Phe Lys Asn Ile Phe Ile Xaa 
1               5                   10                  15      


Met Phe Ala Xaa Phe Phe Phe Phe Lys Leu Leu Ile Lys Val Phe Leu 
            20                  25                  30          


Ala Leu Leu Xaa His Phe Tyr Ile Val Lys Gly Asn Arg Lys Glu Ala 
        35                  40                  45              


Ala Arg Ile Ala Glu Glu Ile Tyr Gly Gly Ile Ser Asp Cys Trp Ala 
    50                  55                  60                  


Asp Arg Ser Pro Leu His Glu Ala Ala Ala Gln Gly Arg Leu Leu Ala 
65                  70                  75                  80  


Leu Lys Xaa Leu Ile Ala Gln Gly Val Asn Val Asn Leu Val Xaa Ile 
                85                  90                  95      


Asn Arg Val Ser Ser Leu His Glu Ala Cys Leu Gly Gly His Val Ala 
            100                 105                 110         


Cys Ala Lys Ala Leu Leu Glu Asn Gly Ala His Val Asn Gly Val Xaa 
        115                 120                 125             


Val His Gly Ala Xaa Pro Leu Phe Asn Ala Cys Cys Ser Gly Ser Ala 
    130                 135                 140                 


Ala Cys Val Asn Val Leu Leu Glu Phe Gly Ala Lys Ala Gln Leu Glu 
145                 150                 155                 160 


Val His Leu Ala Ser Pro Ile His Glu Ala Val Lys Arg Gly His Arg 
                165                 170                 175     


Glu Cys Met Glu Ile Leu Leu Ala Asn Asn Val Asn Ile Asp His Glu 
            180                 185                 190         


Val Pro Gln Leu Gly Xaa Pro Leu Tyr Val Ala Cys Xaa Tyr Gln Arg 
        195                 200                 205             


Val Asp Cys Val Lys Lys Leu Leu Glu Leu Gly Ala Ser Val Asp His 
    210                 215                 220                 


Gly Gln Trp Leu Asp Xaa Pro Leu His Ala Ala Ala Arg Gln Ser Asn 
225                 230                 235                 240 


Val Glu Val Ile His Leu Leu Xaa Asp Tyr Gly Ala Asn Leu Lys Arg 
                245                 250                 255     


Arg Asn Ala Gln Gly Lys Ser Ala Leu Asp Leu Ala Ala Pro Lys Ser 
            260                 265                 270         


Ser Val Glu Gln Ala Leu Leu Leu Arg Glu Gly Pro Pro Ala Leu Ser 
        275                 280                 285             


Gln Leu Cys Arg Leu Cys Val Arg Lys Cys Leu Gly Arg Ala Cys His 
    290                 295                 300                 


Gln Ala Ile His Lys Leu His Leu Pro Glu Pro Leu Glu Arg Phe Leu 
305                 310                 315                 320 


Leu Tyr Gln 
            


<210> 3342
<211> 302
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<400> 3342
Met Leu Gln Leu Xaa Gly Glu Asn Glu Lys Asn Cys Glu Val Ser Glu 
1               5                   10                  15      


Arg Ile Arg Arg Ser Gly Pro Trp Lys Glu Ile Ser Phe Gly Asp Tyr 
            20                  25                  30          


Ile Cys His Xaa Phe Gln Gly Asp Cys Trp Ala Asp Arg Ser Pro Leu 
        35                  40                  45              


His Glu Ala Ala Ala Gln Gly Arg Leu Leu Ala Leu Lys Xaa Leu Ile 
    50                  55                  60                  


Ala Gln Gly Val Asn Val Asn Leu Val Xaa Ile Asn Arg Val Ser Ser 
65                  70                  75                  80  


Leu His Glu Ala Cys Leu Gly Gly His Val Ala Cys Ala Lys Ala Leu 
                85                  90                  95      


Leu Glu Asn Gly Ala His Val Asn Gly Val Xaa Val His Gly Ala Xaa 
            100                 105                 110         


Pro Leu Phe Asn Ala Cys Cys Ser Gly Ser Ala Ala Cys Val Asn Val 
        115                 120                 125             


Leu Leu Glu Phe Gly Ala Lys Ala Gln Leu Glu Val His Leu Ala Ser 
    130                 135                 140                 


Pro Ile His Glu Ala Val Lys Arg Gly His Arg Glu Cys Met Glu Ile 
145                 150                 155                 160 


Leu Leu Ala Asn Asn Val Asn Ile Asp His Glu Val Pro Gln Leu Gly 
                165                 170                 175     


Xaa Pro Leu Tyr Val Ala Cys Xaa Tyr Gln Arg Val Asp Cys Val Lys 
            180                 185                 190         


Lys Leu Leu Glu Leu Gly Ala Ser Val Asp His Gly Gln Trp Leu Asp 
        195                 200                 205             


Xaa Pro Leu His Ala Ala Ala Arg Gln Ser Asn Val Glu Val Ile His 
    210                 215                 220                 


Leu Leu Xaa Asp Tyr Gly Ala Asn Leu Lys Arg Arg Asn Ala Gln Gly 
225                 230                 235                 240 


Lys Ser Ala Leu Asp Leu Ala Ala Pro Lys Ser Ser Val Glu Gln Ala 
                245                 250                 255     


Leu Leu Leu Arg Glu Gly Pro Pro Ala Leu Ser Gln Leu Cys Arg Leu 
            260                 265                 270         


Cys Val Arg Lys Cys Leu Gly Arg Ala Cys His Gln Ala Ile His Lys 
        275                 280                 285             


Leu His Leu Pro Glu Pro Leu Glu Arg Phe Leu Leu Tyr Gln 
    290                 295                 300         


<210> 3343
<211> 318
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<400> 3343
Met Arg Ile Val Leu Gln Leu Ala Lys Met Asn Leu Met Asp Ile Xaa 
1               5                   10                  15      


Lys Ile Phe Ser Leu Leu Gln Pro Asp Lys Glu Glu Glu Asp Xaa Asp 
            20                  25                  30          


Xaa Glu Glu Lys Gln Ala Leu Asn Gln Ala Val Tyr Asp Asn Asp Ser 
        35                  40                  45              


Tyr Xaa Leu Asp Gln Leu Leu Arg Gln Glu Arg Tyr Lys Arg Phe Ile 
    50                  55                  60                  


Asn Ser Arg Ser Gly Trp Gly Val Pro Gly Xaa Pro Leu Arg Leu Ala 
65                  70                  75                  80  


Ala Ser Tyr Gly His Leu Ser Cys Leu Gln Val Leu Leu Ala His Gly 
                85                  90                  95      


Ala Asp Val Asp Ser Leu Asp Val Lys Ala Gln Xaa Pro Leu Phe Xaa 
            100                 105                 110         


Ala Val Ser His Gly His Leu Asp Cys Val Arg Val Leu Leu Glu Ala 
        115                 120                 125             


Gly Ala Ser Pro Gly Gly Ser Ile Tyr Asn Asn Cys Ser Pro Val Leu 
    130                 135                 140                 


Xaa Ala Ala Arg Asp Gly Ala Val Ala Ile Leu Gln Glu Leu Leu Asp 
145                 150                 155                 160 


His Gly Ala Glu Ala Asn Val Lys Ala Lys Leu Pro Val Trp Ala Ser 
                165                 170                 175     


Asn Ile Ala Ser Cys Ser Gly Pro Leu Tyr Leu Ala Ala Val Tyr Gly 
            180                 185                 190         


His Leu Asp Cys Phe Arg Leu Leu Leu Leu His Gly Ala Asp Pro Asp 
        195                 200                 205             


Tyr Asn Cys Xaa Asp Gln Gly Leu Leu Ala Arg Val Pro Arg Pro Arg 
    210                 215                 220                 


Xaa Leu Leu Glu Ile Cys Leu His His Asn Cys Glu Pro Glu Tyr Ile 
225                 230                 235                 240 


Gln Leu Leu Ile Asp Phe Gly Ala Asn Ile Tyr Leu Pro Ser Leu Ser 
                245                 250                 255     


Leu Asp Leu Xaa Ser Gln Asp Asp Lys Gly Ile Ala Leu Leu Leu Gln 
            260                 265                 270         


Ala Arg Ala Xaa Pro Arg Ser Leu Leu Ser Gln Val Arg Leu Val Val 
        275                 280                 285             


Arg Arg Ala Leu Cys Gln Ala Gly Gln Pro Gln Ala Ile Asn Gln Leu 
    290                 295                 300                 


Asp Ile Pro Pro Met Leu Ile Ser Tyr Leu Lys His Gln Leu 
305                 310                 315             


<210> 3344
<211> 173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<400> 3344
Met Glu Pro Arg Ala Ala Asp Gly Cys Phe Leu Gly Asp Val Gly Phe 
1               5                   10                  15      


Trp Val Glu Arg Xaa Pro Val His Glu Ala Ala Gln Arg Gly Glu Ser 
            20                  25                  30          


Leu Gln Leu Gln Gln Leu Ile Glu Ser Gly Ala Cys Val Asn Gln Val 
        35                  40                  45              


Xaa Val Asp Ser Ile Xaa Pro Leu His Ala Ala Ser Leu Gln Gly Gln 
    50                  55                  60                  


Ala Arg Cys Val Gln Leu Leu Leu Ala Ala Gly Ala Gln Val Asp Ala 
65                  70                  75                  80  


Arg Asn Ile Asp Gly Ser Xaa Pro Leu Cys Asp Ala Cys Ala Ser Gly 
                85                  90                  95      


Ser Ile Glu Cys Val Lys Leu Leu Leu Ser Tyr Gly Ala Lys Val Asn 
            100                 105                 110         


Pro Pro Leu Tyr Xaa Ala Ser Pro Leu His Glu Ala Cys Met Ser Gly 
        115                 120                 125             


Ser Ser Glu Cys Val Arg Leu Leu Ile Asp Val Gly Ala Asn Leu Glu 
    130                 135                 140                 


Ala His Asp Cys His Phe Gly Xaa Pro Leu His Val Ala Cys Ala Arg 
145                 150                 155                 160 


Glu His Leu Asp Cys Val Lys Val Leu Leu Asn Ala Ala 
                165                 170             


<210> 3345
<211> 278
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<400> 3345
Met Glu Pro Arg Ala Ala Asp Gly Cys Phe Leu Gly Asp Val Gly Phe 
1               5                   10                  15      


Trp Val Glu Arg Xaa Pro Val His Glu Ala Ala Gln Arg Gly Glu Ser 
            20                  25                  30          


Leu Gln Leu Gln Gln Leu Ile Glu Ser Gly Ala Cys Val Asn Gln Val 
        35                  40                  45              


Xaa Val Asp Ser Ile Xaa Pro Leu His Ala Ala Ser Leu Gln Gly Gln 
    50                  55                  60                  


Ala Arg Cys Val Gln Leu Leu Leu Ala Ala Gly Ala Gln Val Asp Ala 
65                  70                  75                  80  


Arg Asn Ile Asp Gly Ser Xaa Pro Leu Cys Asp Ala Cys Ala Ser Gly 
                85                  90                  95      


Ser Ile Glu Cys Val Lys Leu Leu Leu Ser Tyr Gly Ala Lys Val Asn 
            100                 105                 110         


Pro Pro Leu Tyr Xaa Ala Ser Pro Leu His Glu Ala Cys Met Ser Gly 
        115                 120                 125             


Ser Ser Glu Cys Val Arg Leu Leu Ile Asp Val Gly Ala Asn Leu Glu 
    130                 135                 140                 


Ala His Asp Cys His Phe Gly Xaa Pro Leu His Val Ala Cys Ala Arg 
145                 150                 155                 160 


Glu His Leu Asp Cys Val Lys Val Leu Leu Asn Ala Gly Ala Asn Val 
                165                 170                 175     


Asn Ala Ala Lys Leu His Glu Xaa Ala Leu His His Ala Ala Lys Val 
            180                 185                 190         


Lys Asn Val Asp Leu Ile Glu Met Leu Ile Glu Phe Gly Gly Asn Ile 
        195                 200                 205             


Tyr Ala Arg Asp Asn Arg Gly Lys Lys Pro Ser Asp Tyr Xaa Trp Ser 
    210                 215                 220                 


Ser Ser Ala Pro Ala Lys Cys Phe Glu Tyr Tyr Glu Lys Xaa Pro Leu 
225                 230                 235                 240 


Xaa Leu Ser Gln Leu Cys Arg Val Asn Leu Arg Lys Ala Xaa Gly Val 
                245                 250                 255     


Arg Gly Leu Glu Lys Ile Ala Lys Leu Asn Ile Pro Pro Arg Leu Ile 
            260                 265                 270         


Asp Tyr Leu Ser Tyr Asn 
        275             


<210> 3346
<211> 587
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<400> 3346
Met Asp Asn Tyr Xaa Ser Asp Glu Asp Ile Asp Glu Asp Phe Asp Xaa 
1               5                   10                  15      


Gln Leu Ile Ile Gln Gln Ser Leu Gln Asp Ile Tyr Lys Pro Gly Xaa 
            20                  25                  30          


Ala Gln His Ala Pro Lys Asp Glu Ser Leu His Ser Phe Leu Ser Ala 
        35                  40                  45              


Asp Tyr Lys Lys Ile Val Glu Xaa Ile Glu Lys Gly Lys Glu Asp Ala 
    50                  55                  60                  


Leu Ser His Leu Xaa Lys Tyr His Ser Ala Phe Gly Glu Ala Asp Glu 
65                  70                  75                  80  


Ile Gly Trp Ile Pro Leu His Lys Ala Ala Val Gln Leu Asn Arg Lys 
                85                  90                  95      


Ile Leu Glu Ile Xaa Leu Ser Ala Ser Asp Pro Ser Leu Trp Glu Gln 
            100                 105                 110         


Xaa Xaa His Asn Gly Glu Xaa Pro Leu Phe Leu Ala Val Ser Ser Cys 
        115                 120                 125             


Leu Leu Glu Asn Ala Xaa Phe Leu Leu Leu Asn Gly Cys Asn Pro Asn 
    130                 135                 140                 


Ala Lys Asn Phe Glu Gly Asn Ser Pro Leu Leu Ala Ala Val Leu Arg 
145                 150                 155                 160 


Asp Cys Tyr Asp Met Ala Ala Leu Leu Ile Asn Tyr Gly Ala Asp Val 
                165                 170                 175     


Asn Leu Arg Cys Ala Asn Glu Arg Xaa Ala Leu His Glu Ala Ala Lys 
            180                 185                 190         


Leu Gly Arg Glu Asp Met Val Lys Leu Met Leu Val Ser Gly Ala His 
        195                 200                 205             


Pro Asp Pro Gln Ser Xaa Tyr Gly Phe Xaa Pro Leu Ala Leu Ala Ala 
    210                 215                 220                 


Gln Ser Gly His Xaa Glu Ile Met Glu Met Leu Leu Arg Lys Gly Ala 
225                 230                 235                 240 


Asn Ala His Gly Gln Ala Ser Asp Ser Ser Ser Ile Leu Leu Glu Ala 
                245                 250                 255     


Ala Ser Gly Gly Asn Pro Asp Ala Val Ala Leu Leu Leu Glu Tyr Gly 
            260                 265                 270         


Ala Asp Ala Asn Ile Pro Lys Asn Ser Gly His Leu Pro Ile His Val 
        275                 280                 285             


Ala Ala Asp Arg Gly His Leu Leu Ala Leu Lys Ile Leu Ile Pro Val 
    290                 295                 300                 


Xaa Asp Leu Ala Ala Ile Lys Gln Ser Gly Ile Ser Pro Val His Cys 
305                 310                 315                 320 


Ala Ala Ala Gly Ala His Pro Gln Cys Leu Glu Leu Leu Ile Gln Ala 
                325                 330                 335     


Gly Phe Asp Val Asn Phe Met Leu Asp Gln Arg Ile Asn Lys His Tyr 
            340                 345                 350         


Asp Asp His Arg Lys Ser Ala Leu Tyr Phe Ala Val Ser Asn Ser Asp 
        355                 360                 365             


Leu Ser Ser Val Lys Leu Leu Leu Ser Ala Gly Ala Leu Pro Asn Gln 
    370                 375                 380                 


Asp Pro Val Asn Cys Leu Gln Ile Ala Leu Arg Met Gly Asn Tyr Glu 
385                 390                 395                 400 


Leu Ile Ser Leu Leu Leu Arg His Gly Ala Asn Val Asn Tyr Phe Cys 
                405                 410                 415     


Arg Val Asn Pro Leu His Phe Pro Ser Ala Leu Gln Tyr Xaa Leu Lys 
            420                 425                 430         


Asp Glu Val Met Leu Arg Met Leu Leu Asn Tyr Gly Tyr Asp Xaa Glu 
        435                 440                 445             


Arg Cys Phe Asp Cys Pro His Gly Asp Lys Val His Pro Ser Tyr Xaa 
    450                 455                 460                 


Val Glu Gly Trp Xaa Ser Xaa Val Ile Lys Asp Xaa Lys Phe Cys Glu 
465                 470                 475                 480 


Val Ile Xaa Leu Ser Trp Leu Gln His Leu Ser Gly Lys Val Val Arg 
                485                 490                 495     


Val Met Leu Asp Tyr Val Asp Gln Val Arg Ile Cys Ser Lys Leu Lys 
            500                 505                 510         


Ala Val Leu Gln Lys Gln Gly Ile Trp Ser Glu Ile His Phe Ile Leu 
        515                 520                 525             


Xaa Asn Pro Arg Ser Leu Lys His Leu Cys Arg Leu Lys Ile Arg Lys 
    530                 535                 540                 


Cys Met Gly Arg Leu His Leu Arg Cys Pro Val Phe Met Ser Phe Leu 
545                 550                 555                 560 


Pro Leu Pro Asn Arg Leu Lys Ala Tyr Val Leu Tyr Lys Glu Tyr Asp 
                565                 570                 575     


Leu Tyr Gly Gln Gly Ile Phe Xaa Gly Xaa Trp 
            580                 585         


<210> 3347
<211> 587
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<400> 3347
Met Asp Asn Tyr Xaa Ser Asp Glu Asp Ile Asp Glu Asp Phe Asp Xaa 
1               5                   10                  15      


Gln Leu Ile Ile Gln Gln Ser Leu Gln Asp Ile Tyr Lys Pro Gly Xaa 
            20                  25                  30          


Ala Gln His Ala Pro Lys Asp Glu Ser Leu His Ser Phe Leu Ser Ala 
        35                  40                  45              


Asp Tyr Lys Lys Ile Val Glu Xaa Ile Glu Lys Val Gly Lys Glu Asp 
    50                  55                  60                  


Ala Leu Ser His Leu Xaa Lys Tyr His Ser Ala Phe Gly Glu Ala Asp 
65                  70                  75                  80  


Glu Ile Gly Trp Ile Pro Leu His Lys Ala Ala Val Gln Leu Asn Arg 
                85                  90                  95      


Lys Ile Leu Glu Ile Xaa Leu Ser Ala Ser Asp Pro Ser Leu Trp Glu 
            100                 105                 110         


Gln Xaa Xaa His Asn Gly Glu Xaa Pro Leu Phe Leu Ala Val Ser Ser 
        115                 120                 125             


Cys Leu Leu Glu Asn Ala Xaa Phe Leu Leu Leu Asn Gly Cys Asn Pro 
    130                 135                 140                 


Asn Ala Lys Asn Phe Glu Gly Asn Ser Pro Leu Leu Ala Ala Val Leu 
145                 150                 155                 160 


Arg Asp Cys Tyr Asp Met Ala Ala Leu Leu Ile Asn Tyr Gly Ala Asp 
                165                 170                 175     


Val Asn Leu Arg Cys Ala Asn Glu Arg Xaa Ala Leu His Glu Ala Ala 
            180                 185                 190         


Lys Leu Gly Arg Glu Asp Met Val Lys Leu Met Leu Val Ser Gly Ala 
        195                 200                 205             


His Pro Asp Pro Gln Ser Xaa Tyr Gly Phe Xaa Pro Leu Ala Leu Ala 
    210                 215                 220                 


Ala Gln Ser Gly His Xaa Glu Ile Met Glu Met Leu Leu Arg Lys Gly 
225                 230                 235                 240 


Lys Ile Phe Cys Leu Ala Ser Asp Ser Ser Ser Ile Leu Leu Glu Ala 
                245                 250                 255     


Ala Ser Gly Gly Asn Pro Asp Ala Val Ala Leu Leu Leu Glu Tyr Gly 
            260                 265                 270         


Ala Asp Ala Asn Ile Pro Lys Asn Ser Gly His Leu Pro Ile His Val 
        275                 280                 285             


Ala Ala Asp Arg Gly His Leu Leu Ala Leu Lys Ile Leu Ile Pro Val 
    290                 295                 300                 


Xaa Asp Leu Ala Ala Ile Lys Gln Ser Gly Ile Ser Pro Val His Cys 
305                 310                 315                 320 


Ala Ala Ala Gly Ala His Pro Gln Cys Leu Glu Leu Leu Ile Gln Ala 
                325                 330                 335     


Gly Phe Asp Val Asn Phe Met Leu Asp Gln Arg Ile Asn Lys His Tyr 
            340                 345                 350         


Asp Asp His Arg Lys Ser Ala Leu Tyr Phe Ala Val Ser Asn Ser Asp 
        355                 360                 365             


Leu Ser Ser Val Lys Leu Leu Leu Ser Ala Gly Ala Leu Pro Asn Gln 
    370                 375                 380                 


Asp Pro Val Asn Cys Leu Gln Ile Ala Leu Arg Met Gly Asn Tyr Glu 
385                 390                 395                 400 


Leu Ile Ser Leu Leu Leu Arg His Gly Ala Asn Val Asn Tyr Phe Cys 
                405                 410                 415     


Arg Val Asn Pro Leu His Phe Pro Ser Ala Leu Gln Tyr Xaa Leu Lys 
            420                 425                 430         


Asp Glu Val Met Leu Arg Met Leu Leu Asn Tyr Gly Tyr Asp Xaa Glu 
        435                 440                 445             


Arg Cys Phe Asp Cys Pro His Gly Asp Lys Val His Pro Ser Tyr Xaa 
    450                 455                 460                 


Val Glu Gly Trp Xaa Ser Xaa Val Ile Lys Asp Xaa Lys Phe Cys Glu 
465                 470                 475                 480 


Val Ile Xaa Leu Ser Trp Leu Gln His Leu Ser Gly Lys Val Val Arg 
                485                 490                 495     


Val Met Leu Asp Tyr Val Asp Gln Val Arg Ile Cys Ser Lys Leu Lys 
            500                 505                 510         


Ala Val Leu Gln Lys Gln Gly Ile Trp Ser Glu Ile His Phe Ile Leu 
        515                 520                 525             


Xaa Asn Pro Arg Ser Leu Lys His Leu Cys Arg Leu Lys Ile Arg Lys 
    530                 535                 540                 


Cys Met Gly Arg Leu His Leu Arg Cys Pro Val Phe Met Ser Phe Leu 
545                 550                 555                 560 


Pro Leu Pro Asn Arg Leu Lys Ala Tyr Val Leu Tyr Lys Glu Tyr Asp 
                565                 570                 575     


Leu Tyr Gly Gln Gly Ile Phe Xaa Gly Xaa Trp 
            580                 585         


<210> 3348
<211> 97
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<400> 3348
Met Asp Xaa Asn Asp Asp Pro Asp Glu Asp His Leu Xaa Ser Tyr Asp 
1               5                   10                  15      


Ile Gln Leu Ser Ile Gln Glu Ser Ile Glu Ala Ser Lys Xaa Ala Leu 
            20                  25                  30          


Cys Pro Glu Arg Phe Val Pro Leu Ser Ala Gln Asn Arg Lys Leu Val 
        35                  40                  45              


Glu Ala Ile Lys Gln Gly His Ile Pro Glu Leu Gln Glu Tyr Val Lys 
    50                  55                  60                  


Tyr Lys Tyr Ala Met Asp Glu Ala Asp Glu Lys Gly Trp Phe Pro Leu 
65                  70                  75                  80  


His Glu Ala Val Val Gln Pro Ile Gln Gln Ile Leu Glu Ile Val Leu 
                85                  90                  95      


Asp 
    


<210> 3349
<211> 241
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<400> 3349
Met Asp Xaa Asn Asp Asp Pro Asp Glu Asp His Leu Xaa Ser Tyr Asp 
1               5                   10                  15      


Ile Gln Leu Ser Ile Gln Glu Ser Ile Glu Ala Ser Lys Xaa Ala Leu 
            20                  25                  30          


Cys Pro Glu Arg Phe Val Pro Leu Ser Ala Gln Asn Arg Lys Leu Val 
        35                  40                  45              


Glu Ala Ile Lys Gln Gly His Ile Pro Glu Leu Gln Glu Tyr Val Lys 
    50                  55                  60                  


Tyr Lys Tyr Ala Met Asp Glu Ala Asp Glu Lys Gly Trp Phe Pro Leu 
65                  70                  75                  80  


His Glu Ala Val Val Gln Pro Ile Gln Gln Ile Leu Glu Ile Val Leu 
                85                  90                  95      


Asp Ala Ser Tyr Lys Xaa Leu Trp Glu Phe Lys Xaa Cys Asp Gly Glu 
            100                 105                 110         


Xaa Pro Leu Xaa Leu Ala Val Lys Ala Gly Leu Val Glu Asn Val Arg 
        115                 120                 125             


Xaa Leu Leu Glu Lys Gly Val Trp Pro Asn Xaa Lys Asn Asp Lys Gly 
    130                 135                 140                 


Glu Xaa Pro Leu Leu Ile Ala Val Lys Lys Gly Ser Tyr Asp Met Val 
145                 150                 155                 160 


Ser Xaa Leu Ile Lys His Asn Xaa Ser Leu Asp Gln Pro Cys Val Lys 
                165                 170                 175     


Arg Trp Ser Ala Met His Glu Ala Ala Lys Gln Gly Arg Lys Asp Ile 
            180                 185                 190         


Val Ala Leu Leu Leu Lys His Gly Gly Asn Val His Leu Arg Asp Gly 
        195                 200                 205             


Phe Gly Val Xaa Pro Leu Gly Val Ala Ala Glu Tyr Gly His Cys Asp 
    210                 215                 220                 


Val Leu Glu His Leu Ile His Lys Gly Gly Asp Val Leu Ala Leu Ala 
225                 230                 235                 240 


Asp 
    


<210> 3350
<211> 588
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<400> 3350
Met Asp Xaa Asn Asp Asp Pro Asp Glu Asp His Leu Xaa Ser Tyr Asp 
1               5                   10                  15      


Ile Gln Leu Ser Ile Gln Glu Ser Ile Glu Ala Ser Lys Xaa Ala Leu 
            20                  25                  30          


Cys Pro Glu Arg Phe Val Pro Leu Ser Ala Gln Asn Arg Lys Leu Val 
        35                  40                  45              


Glu Ala Ile Lys Gln Gly His Ile Pro Glu Leu Gln Glu Tyr Val Lys 
    50                  55                  60                  


Tyr Lys Tyr Ala Met Asp Glu Ala Asp Glu Lys Gly Trp Phe Pro Leu 
65                  70                  75                  80  


His Glu Ala Val Val Gln Pro Ile Gln Gln Ile Leu Glu Ile Val Leu 
                85                  90                  95      


Asp Ala Ser Tyr Lys Xaa Leu Trp Glu Phe Lys Xaa Cys Asp Gly Glu 
            100                 105                 110         


Xaa Pro Leu Xaa Leu Ala Val Lys Ala Gly Leu Val Glu Asn Val Arg 
        115                 120                 125             


Xaa Leu Leu Glu Lys Gly Val Trp Pro Asn Xaa Lys Asn Asp Lys Gly 
    130                 135                 140                 


Glu Xaa Pro Leu Leu Ile Ala Val Lys Lys Gly Ser Tyr Asp Met Val 
145                 150                 155                 160 


Ser Xaa Leu Ile Lys His Asn Xaa Ser Leu Asp Gln Pro Cys Val Lys 
                165                 170                 175     


Arg Trp Ser Ala Met His Glu Ala Ala Lys Gln Gly Arg Lys Asp Ile 
            180                 185                 190         


Val Ala Leu Leu Leu Lys His Gly Gly Asn Val His Leu Arg Asp Gly 
        195                 200                 205             


Phe Gly Val Xaa Pro Leu Gly Val Ala Ala Glu Tyr Gly His Cys Asp 
    210                 215                 220                 


Val Leu Glu His Leu Ile His Lys Gly Gly Asp Val Leu Ala Leu Ala 
225                 230                 235                 240 


Asp Asp Gly Ala Ser Val Leu Phe Glu Ala Ala Gly Gly Gly Asn Pro 
                245                 250                 255     


Asp Cys Ile Ser Leu Leu Leu Glu Tyr Gly Gly Ser Gly Asn Val Pro 
            260                 265                 270         


Asn Arg Ala Gly His Leu Pro Ile His Arg Ala Ala Tyr Glu Gly His 
        275                 280                 285             


Tyr Leu Ala Leu Lys Tyr Leu Ile Pro Val Xaa Ser Lys Asn Ala Ile 
    290                 295                 300                 


Arg Lys Ser Gly Leu Xaa Pro Ile His Ser Ala Ala Asp Gly Gln Asn 
305                 310                 315                 320 


Ala Gln Cys Leu Glu Leu Leu Ile Glu Asn Gly Phe Asp Val Asn Xaa 
                325                 330                 335     


Leu Leu Ala Asp His Ile Ser Gln Ser Tyr Asp Asp Glu Arg Lys Xaa 
            340                 345                 350         


Ala Leu Tyr Phe Gly Val Ser Asn Asn Asp Val His Cys Xaa Glu Val 
        355                 360                 365             


Leu Leu Ala Ala Gly Ala Asp Pro Asn Leu Asp Pro Leu Asn Cys Leu 
    370                 375                 380                 


Leu Val Ala Val Arg Ala Asn Asn Tyr Glu Ile Val Arg Leu Leu Leu 
385                 390                 395                 400 


Ser His Gly Ala Asn Val Asn Cys Tyr Phe Met His Val Asn Asp Xaa 
                405                 410                 415     


Arg Phe Pro Ser Val Ile Gln Tyr Ala Leu Asn Asp Glu Val Met Leu 
            420                 425                 430         


Arg Leu Leu Leu Asn Asn Gly Tyr Gln Val Glu Met Cys Phe Asp Cys 
        435                 440                 445             


Met His Gly Asp Ile Phe Gly Asn Ser Phe Val Trp Ser Glu Ile Gln 
    450                 455                 460                 


Glu Glu Val Leu Pro Gly Trp Xaa Ser Cys Val Ile Lys Asp Asn Pro 
465                 470                 475                 480 


Phe Cys Glu Phe Ile Xaa Val Pro Trp Met Lys His Leu Val Gly Arg 
                485                 490                 495     


Val Xaa Arg Val Leu Ile Asp Tyr Met Asp Tyr Val Pro Leu Cys Ala 
            500                 505                 510         


Lys Leu Lys Ser Ala Leu Glu Val Gln Arg Glu Trp Pro Glu Ile Arg 
        515                 520                 525             


Gln Ile Leu Glu Asn Pro Cys Ser Leu Lys His Leu Cys Arg Leu Lys 
    530                 535                 540                 


Ile Arg Arg Leu Met Gly Leu Gln Lys Leu Cys Gln Pro Ala Ser Val 
545                 550                 555                 560 


Glu Lys Leu Pro Leu Pro Pro Ala Ile Gln Arg Tyr Ile Leu Phe Lys 
                565                 570                 575     


Glu Tyr Asp Leu Tyr Gly Gln Glu Leu Lys Leu Xaa 
            580                 585             


<210> 3351
<211> 249
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<400> 3351
Met Lys Gln Pro Ser Lys Ala Glu Tyr Gly His Cys Asp Val Leu Glu 
1               5                   10                  15      


His Leu Ile His Lys Gly Gly Asp Val Leu Ala Leu Ala Asp Asp Gly 
            20                  25                  30          


Ala Ser Val Leu Phe Glu Ala Ala Gly Gly Gly Asn Pro Asp Cys Ile 
        35                  40                  45              


Ser Leu Leu Leu Glu Tyr Gly Gly Ser Gly Asn Val Pro Asn Arg Ala 
    50                  55                  60                  


Gly His Leu Pro Ile His Arg Ala Ala Tyr Glu Gly His Tyr Leu Ala 
65                  70                  75                  80  


Leu Lys Tyr Leu Ile Pro Val Xaa Ser Lys Asn Ala Ile Arg Lys Ser 
                85                  90                  95      


Gly Leu Xaa Pro Ile His Ser Ala Ala Asp Gly Gln Asn Ala Gln Cys 
            100                 105                 110         


Leu Glu Leu Leu Ile Glu Asn Gly Phe Asp Val Asn Xaa Leu Leu Ala 
        115                 120                 125             


Asp His Ile Ser Gln Ser Tyr Asp Asp Glu Arg Lys Xaa Ala Leu Tyr 
    130                 135                 140                 


Phe Gly Val Ser Asn Asn Asp Val His Cys Xaa Glu Val Leu Leu Ala 
145                 150                 155                 160 


Ala Gly Ala Asp Pro Asn Leu Asp Pro Leu Asn Cys Leu Leu Val Ala 
                165                 170                 175     


Val Arg Ala Asn Asn Tyr Glu Ile Val Arg Leu Leu Leu Ser His Gly 
            180                 185                 190         


Ala Asn Val Asn Cys Tyr Phe Met His Val Asn Asp Xaa Arg Phe Pro 
        195                 200                 205             


Ser Val Ile Gln Tyr Ala Leu Asn Asp Glu Val Met Leu Arg Leu Leu 
    210                 215                 220                 


Leu Asn Asn Gly Tyr Gln Val Glu Met Cys Phe Asp Cys Met His Gly 
225                 230                 235                 240 


Asp Ile Phe Gly Asn Ser Phe Val Cys 
                245                 


<210> 3352
<211> 273
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<400> 3352
Met Ala Arg Glu Xaa Phe Pro Phe Xaa Ser Ser Met Leu Arg Ser Leu 
1               5                   10                  15      


Arg Leu Gln Gln Glu Trp Leu Glu Trp Glu Asp Arg Arg Arg Ala Ala 
            20                  25                  30          


Ala Gln Gln Cys Arg Ser Arg Arg Cys Pro Ser Ser Pro Arg Ala Arg 
        35                  40                  45              


Leu Xaa Arg Pro His Arg Ser Cys Arg Asp Pro Ala Val His Gln Ala 
    50                  55                  60                  


Leu Phe Ser Gly Asn Leu Gln Gln Val Gln Ala Leu Phe Gln Asp Glu 
65                  70                  75                  80  


Glu Ala Ala Asn Met Ile Val Glu Xaa Val Ser Asn Gln Leu Ala Trp 
                85                  90                  95      


Ser Ala Glu Gln Gly Phe Trp Val Leu Xaa Pro Lys Xaa Lys Gln Xaa 
            100                 105                 110         


Ala Pro Leu Ala Ile Ala Xaa Ala Arg Gly Tyr Xaa Asp Cys Ala Arg 
        115                 120                 125             


His Leu Ile Arg Gln Gly Ala Glu Leu Asp Ala Arg Val Gly Gly Arg 
    130                 135                 140                 


Ala Ala Leu His Glu Ala Cys Ala Arg Ala Gln Phe Asp Cys Val Arg 
145                 150                 155                 160 


Leu Leu Leu Xaa Phe Gly Ala Lys Ala Asn Val Leu Xaa Glu Glu Gly 
                165                 170                 175     


Xaa Xaa Pro Leu His Leu Cys Xaa Ile Pro Glu Ser Leu Gln Cys Ala 
            180                 185                 190         


Lys Leu Leu Leu Glu Ala Gly Ala Xaa Val Asn Leu Ala Ala Gly Glu 
        195                 200                 205             


Ser Gln Glu Xaa Pro Leu His Val Ala Ala Ala Arg Gly Leu Glu Gln 
    210                 215                 220                 


His Val Ala Leu Tyr Leu Glu His Gly Ala Asp Val Gly Leu Arg Xaa 
225                 230                 235                 240 


Ser Gln Gly Glu Xaa Ala Leu Asn Xaa Ala Cys Ala Gly Ala Glu Gly 
                245                 250                 255     


Pro Asp Ala Glu Xaa Leu Arg Gln Leu Pro Ser Gly Pro Gly Ser Pro 
            260                 265                 270         


Ala 
    


<210> 3353
<211> 453
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<400> 3353
Met Ala Arg Glu Xaa Phe Pro Phe Xaa Ser Ser Met Leu Arg Ser Leu 
1               5                   10                  15      


Arg Leu Gln Gln Glu Trp Leu Glu Trp Glu Asp Arg Arg Arg Ala Ala 
            20                  25                  30          


Ala Gln Gln Cys Arg Ser Arg Arg Cys Pro Ser Ser Pro Arg Ala Arg 
        35                  40                  45              


Leu Xaa Arg Pro His Arg Ser Cys Arg Asp Pro Ala Val His Gln Ala 
    50                  55                  60                  


Leu Phe Ser Gly Asn Leu Gln Gln Val Gln Ala Leu Phe Gln Asp Glu 
65                  70                  75                  80  


Glu Ala Ala Asn Met Ile Val Glu Xaa Val Ser Asn Gln Leu Ala Trp 
                85                  90                  95      


Ser Ala Glu Gln Gly Phe Trp Val Leu Xaa Pro Lys Xaa Lys Gln Xaa 
            100                 105                 110         


Ala Pro Leu Ala Ile Ala Xaa Ala Arg Gly Tyr Xaa Asp Cys Ala Arg 
        115                 120                 125             


His Leu Ile Arg Gln Gly Ala Glu Leu Asp Ala Arg Val Gly Gly Arg 
    130                 135                 140                 


Ala Ala Leu His Glu Ala Cys Ala Arg Ala Gln Phe Asp Cys Val Arg 
145                 150                 155                 160 


Leu Leu Leu Xaa Phe Gly Ala Lys Ala Asn Val Leu Xaa Glu Glu Gly 
                165                 170                 175     


Xaa Xaa Pro Leu His Leu Cys Xaa Ile Pro Glu Ser Leu Gln Cys Ala 
            180                 185                 190         


Lys Leu Leu Leu Glu Ala Gly Ala Xaa Val Asn Leu Ala Ala Gly Glu 
        195                 200                 205             


Ser Gln Glu Xaa Pro Leu His Val Ala Ala Ala Arg Gly Leu Glu Gln 
    210                 215                 220                 


His Val Ala Leu Tyr Leu Glu His Gly Ala Asp Val Gly Leu Arg Xaa 
225                 230                 235                 240 


Ser Gln Gly Glu Xaa Ala Leu Asn Xaa Ala Cys Ala Gly Ala Glu Gly 
                245                 250                 255     


Pro Gly Ser Cys Arg Arg His Gln Ala Ala Ala Arg Arg Leu Leu Glu 
            260                 265                 270         


Ala Gly Ala Asp Ala Arg Ala Ala Gly Arg Lys Arg His Xaa Pro Leu 
        275                 280                 285             


His Asn Ala Cys Ala Asn Gly Cys Gly Gly Leu Ala Glu Leu Leu Leu 
    290                 295                 300                 


Arg Tyr Gly Ala Arg Ala Glu Val Pro Asn Gly Ala Gly His Xaa Pro 
305                 310                 315                 320 


Met Asp Cys Ala Leu Gln Ala Val Gln Asp Ser Pro Asn Trp Glu Pro 
                325                 330                 335     


Glu Val Leu Phe Ala Ala Leu Leu Asp Tyr Gly Ala Gln Pro Val Arg 
            340                 345                 350         


Pro Glu Met Leu Lys His Cys Ala Asn Phe Pro Arg Ala Leu Glu Val 
        355                 360                 365             


Leu Leu Asn Ala Tyr Pro Cys Val Pro Ser Cys Glu Xaa Trp Val Glu 
    370                 375                 380                 


Ala Val Leu Pro Glu Leu Trp Lys Glu His Glu Ala Phe Tyr Ser Ser 
385                 390                 395                 400 


Ala Leu Cys Met Val Asn Gln Pro Arg Gln Leu Gln His Leu Ala Arg 
                405                 410                 415     


Leu Ala Val Arg Ala Arg Leu Gly Ser Arg Cys Arg Gln Gly Ala Xaa 
            420                 425                 430         


Arg Leu Pro Leu Pro Pro Leu Leu Arg Asp Tyr Leu Leu Leu Arg Val 
        435                 440                 445             


Glu Gly Cys Ile Gln 
    450             


<210> 3354
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<400> 3354
Met Ile Val Glu Xaa Val Ser Asn Gln Leu Ala Trp Ser Ala Glu Gln 
1               5                   10                  15      


Gly Phe Trp Val Leu Xaa Pro Lys Xaa Lys Gln Xaa Ala Pro Leu Ala 
            20                  25                  30          


Ile Ala Xaa Ala Arg Gly Tyr Xaa Asp Cys Ala Arg His Leu Ile Arg 
        35                  40                  45              


Gln Gly Ala Glu Leu Asp Ala Arg Val Gly Gly Arg Ala Ala Leu His 
    50                  55                  60                  


Glu Ala Cys Ala Arg Ala Gln 
65                  70      


<210> 3355
<211> 295
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<400> 3355
Met Ser Lys Ser Xaa Lys Leu Cys Gly Lys Xaa Ser Cys Pro Arg Ser 
1               5                   10                  15      


Asn Ile Phe Cys Asn Leu Leu Asp Lys Ile Val Lys Arg Pro Ser Leu 
            20                  25                  30          


Gln Phe Leu Gly Gln Trp Gly Tyr His Cys Tyr Glu Pro Arg Ile Tyr 
        35                  40                  45              


Arg Ser Leu Ala Lys Ile Leu Arg Tyr Val Asp Leu Asp Gly Phe Asp 
    50                  55                  60                  


Ala Leu Leu Xaa Asp Tyr Ile Ala Phe Val Glu Lys Ser Gly Tyr Arg 
65                  70                  75                  80  


Phe Glu Val Ser Phe Asn Leu Asp Phe Xaa Glu Ile Cys Val Asn Xaa 
                85                  90                  95      


Ile Leu Tyr Trp Val Phe Ala Arg Lys Gly Asn Pro Asp Phe Val Glu 
            100                 105                 110         


Leu Leu Leu Lys Lys Xaa Lys Asp Tyr Val Gln Asp Arg Ser Cys Asn 
        115                 120                 125             


Leu Ala Leu Ile Trp Arg Xaa Phe Xaa Pro Val Tyr Cys Pro Ser Pro 
    130                 135                 140                 


Leu Ser Gly Ile Xaa Pro Leu Phe Tyr Val Ala Gln Xaa Arg Gln Ser 
145                 150                 155                 160 


Asn Ile Phe Lys Ile Leu Leu Gln Tyr Gly Ile Leu Glu Arg Glu Lys 
                165                 170                 175     


Asn Pro Ile Asn Ile Val Leu Xaa Ile Val Leu Tyr Pro Ser Arg Val 
            180                 185                 190         


Arg Val Met Val Asp Arg Glu Leu Ala Asp Ile His Glu Asp Ala Lys 
        195                 200                 205             


Xaa Cys Leu Val Leu Cys Ser Arg Val Leu Ser Val Ile Ser Val Lys 
    210                 215                 220                 


Glu Ile Lys Xaa Gln Leu Ser Leu Gly Arg His Pro Ile Ile Ser Asn 
225                 230                 235                 240 


Trp Phe Asp Tyr Ile Pro Ser Xaa Arg Tyr Lys Asp Pro Cys Glu Leu 
                245                 250                 255     


Leu His Leu Cys Arg Leu Xaa Ile Arg Asn Gln Leu Leu Xaa Asn Asn 
            260                 265                 270         


Met Leu Pro Asp Gly Ile Phe Ser Leu Leu Ile Pro Ala Arg Leu Gln 
        275                 280                 285             


Asn Tyr Leu Asn Leu Glu Ile 
    290                 295 


<210> 3356
<211> 148
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<400> 3356
Ala Arg Asp Glu Asp Glu Arg Ser Pro Leu His Lys Ala Cys Gly His 
1               5                   10                  15      


Ala Ser His Ser Leu Ala Arg Leu Leu Leu Arg His Gly Ala Asp Ala 
            20                  25                  30          


Gly Ala Leu Asp Tyr Gly Gly Ala Ser Pro Leu Gly Arg Val Leu Gln 
        35                  40                  45              


Xaa Ala Ser Cys Ala Leu Gln Ala Ser Pro Gln Arg Xaa Val Gln Ala 
    50                  55                  60                  


Leu Leu Asn His Gly Ser Pro Xaa Val Trp Pro Asp Ala Phe Pro Lys 
65                  70                  75                  80  


Val Leu Lys Xaa Cys Ala Ser Val Pro Ala Val Ile Glu Val Leu Phe 
                85                  90                  95      


Asn Ser Tyr Pro Gln Leu Cys Leu Ser Glu Ser Trp Lys Glu Val Ile 
            100                 105                 110         


Pro Glu Glu Val Phe Gln Ala Arg Gly Leu Pro Phe Cys Pro Ser Leu 
        115                 120                 125             


Val Gln Asn Phe Cys Leu Phe Leu Leu Leu Cys Met Gly Ser Phe Ala 
    130                 135                 140                 


Leu Ile Phe Gly 
145             


<210> 3357
<211> 466
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<400> 3357
Met Ser Asn Ser Asp Tyr Leu Pro Asp Tyr Pro Leu Asn Ser Asp Leu 
1               5                   10                  15      


Val Lys Arg Leu Lys Ser Ala Leu Asp Ala Lys Asp Glu Glu Arg Val 
            20                  25                  30          


Arg Asp Leu Ile Cys Xaa Glu Ile Xaa Pro Val Asp Ala Val Ile Glu 
        35                  40                  45              


Leu Ala Asn Asp Asp Trp Met Lys Asp Pro Ser Ala Gln Leu Pro Xaa 
    50                  55                  60                  


Gly Met Leu Leu Gly Asp Leu Asp His Leu Lys Pro Leu Met Asp Gln 
65                  70                  75                  80  


Phe Phe Gln Asp Ala Asn Val Val Phe Glu Ile Asn Lys Asp Glu Met 
                85                  90                  95      


Glu Trp Gln Val Lys Ser Pro Ala Xaa Phe Gly Leu Ser Gly Leu Trp 
            100                 105                 110         


Xaa Leu Glu Tyr Lys Arg Glu Leu Xaa Xaa Pro Leu Cys Ile Ala Ala 
        115                 120                 125             


Ala His Gly His Xaa Ala Cys Val Arg His Leu Leu Gly Arg Gly Ala 
    130                 135                 140                 


Asp Pro Asp Ala Ser Pro Gly Gly Arg Gly Ala Leu His Glu Ala Cys 
145                 150                 155                 160 


Leu Gly Gly His Xaa Ala Cys Val Arg Leu Leu Leu Gln His Arg Ala 
                165                 170                 175     


Asp Pro Asp Leu Leu Ser Ala Glu Gly Leu Ala Pro Leu His Leu Cys 
            180                 185                 190         


Arg Xaa Ala Ala Ser Leu Gly Cys Ala Gln Ala Leu Leu Glu His Gly 
        195                 200                 205             


Ala Ser Val Gln Arg Val Gly Gly Xaa Gly Arg Asp Xaa Pro Leu His 
    210                 215                 220                 


Val Ala Ala Gln Arg Gly Leu Asp Glu His Ala Arg Leu Tyr Leu Gly 
225                 230                 235                 240 


Arg Gly Ala His Val Asp Ala Arg Asn Gly Arg Gly Glu Xaa Ala Leu 
                245                 250                 255     


Ser Ala Ala Cys Gly Ala Ala Arg Arg Pro Asp Glu His Gly Arg Cys 
            260                 265                 270         


Leu Arg Leu Cys Ala Leu Leu Leu Arg Arg Gly Ala Glu Ala Asp Ala 
        275                 280                 285             


Arg Asp Glu Asp Glu Arg Ser Pro Leu His Lys Ala Cys Gly His Ala 
    290                 295                 300                 


Ser His Ser Leu Ala Arg Leu Leu Leu Arg His Gly Ala Asp Ala Gly 
305                 310                 315                 320 


Ala Leu Asp Tyr Gly Gly Ala Ser Pro Leu Gly Arg Val Leu Gln Xaa 
                325                 330                 335     


Ala Ser Cys Ala Leu Gln Ala Ser Pro Gln Arg Xaa Val Gln Ala Leu 
            340                 345                 350         


Leu Asn His Gly Ser Pro Xaa Val Trp Pro Asp Ala Phe Pro Lys Val 
        355                 360                 365             


Leu Lys Xaa Cys Ala Ser Val Pro Ala Val Ile Glu Val Leu Phe Asn 
    370                 375                 380                 


Ser Tyr Pro Gln Leu Cys Leu Ser Glu Ser Trp Lys Glu Val Ile Pro 
385                 390                 395                 400 


Glu Glu Val Phe Gln Met His Lys Pro Phe Tyr Gln Ser Leu Phe Ala 
                405                 410                 415     


Leu Ala Leu Xaa Pro Arg Cys Leu Gln His Leu Cys Arg Cys Ala Leu 
            420                 425                 430         


Arg Arg Leu Phe Gly Lys Arg Cys Phe Asp Leu Ile Pro Leu Leu Pro 
        435                 440                 445             


Leu Pro Lys Pro Leu Gln Asn Tyr Leu Leu Leu Glu Pro Gln Gly Val 
    450                 455                 460                 


Leu His 
465     


<210> 3358
<211> 195
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<400> 3358
Met Ser Asn Ser Asp Tyr Leu Pro Asp Tyr Pro Leu Asn Ser Asp Leu 
1               5                   10                  15      


Val Lys Arg Leu Lys Ser Ala Leu Asp Ala Lys Asp Glu Glu Arg Val 
            20                  25                  30          


Arg Asp Leu Ile Cys Xaa Glu Ile Xaa Pro Val Asp Ala Val Ile Glu 
        35                  40                  45              


Leu Ala Asn Asp Asp Trp Met Lys Asp Pro Ser Ala Gln Leu Pro Xaa 
    50                  55                  60                  


Gly Met Leu Leu Gly Leu Trp Xaa Leu Glu Tyr Lys Arg Glu Leu Xaa 
65                  70                  75                  80  


Xaa Pro Leu Cys Ile Ala Ala Ala His Gly His Xaa Ala Cys Val Arg 
                85                  90                  95      


His Leu Leu Gly Arg Gly Ala Asp Pro Asp Ala Ser Pro Gly Gly Arg 
            100                 105                 110         


Gly Ala Leu His Glu Ala Cys Leu Gly Gly His Xaa Ala Cys Val Arg 
        115                 120                 125             


Leu Leu Leu Gln His Arg Ala Asp Pro Asp Leu Leu Ser Ala Glu Gly 
    130                 135                 140                 


Leu Ala Pro Leu His Leu Cys Arg Xaa Ala Ala Ser Leu Gly Cys Ala 
145                 150                 155                 160 


Gln Ala Leu Leu Glu His Gly Ala Ser Val Gln Arg Val Gly Gly Xaa 
                165                 170                 175     


Gly Arg Asp Xaa Pro Leu His Val Ala Ala Gln Arg Gly Leu Asp Glu 
            180                 185                 190         


His Ala Arg 
        195 


<210> 3359
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 3359
Met Ala Xaa Gln Ile Ser Xaa Arg Gly Ser Gln Cys Xaa Ile Gly Gln 
1               5                   10                  15      


Glu Glu Tyr Ser Leu Tyr Ser Ser Leu Ser Glu Asp Glu Leu Val Gln 
            20                  25                  30          


Met Ala Ile Glu Gln Ser Leu Ala Asp Lys Xaa Arg Gly Pro Xaa Xaa 
        35                  40                  45              


Ala Glu Ala Xaa Ala Ser Ala Cys Xaa Asn Arg Gln Pro Ala His Phe 
    50                  55                  60                  


Tyr Pro Trp Xaa Arg Pro Ala Asp Pro Leu Ile Lys Ala Ile Lys Asp 
65                  70                  75                  80  


Gly Asp Glu Glu Ala Leu Lys Xaa Met Ile Lys Glu Gly Lys Asn Leu 
                85                  90                  95      


Ala Glu Pro Asn Lys Glu Gly Trp Leu Pro Leu His Glu Ala Ala Tyr 
            100                 105                 110         


Tyr Gly Gln Val Gly Cys Leu Lys Val Leu 
        115                 120         


<210> 3360
<211> 635
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<400> 3360
Met Ala Xaa Gln Ile Ser Xaa Arg Gly Ser Gln Cys Xaa Ile Gly Gln 
1               5                   10                  15      


Glu Glu Tyr Ser Leu Tyr Ser Ser Leu Ser Glu Asp Glu Leu Val Gln 
            20                  25                  30          


Met Ala Ile Glu Gln Ser Leu Ala Asp Lys Xaa Arg Gly Pro Xaa Xaa 
        35                  40                  45              


Ala Glu Ala Xaa Ala Ser Ala Cys Xaa Asn Arg Gln Pro Ala His Phe 
    50                  55                  60                  


Tyr Pro Trp Xaa Arg Ser Xaa Ala Pro Pro Glu Ser Ser Pro Ala Arg 
65                  70                  75                  80  


Ala Pro Met Gly Leu Phe Gln Gly Val Met Gln Lys Tyr Ser Ser Ser 
                85                  90                  95      


Leu Phe Lys Xaa Ser Gln Leu Ala Pro Ala Asp Pro Leu Ile Lys Ala 
            100                 105                 110         


Ile Lys Asp Gly Asp Glu Glu Ala Leu Lys Xaa Met Ile Lys Glu Gly 
        115                 120                 125             


Lys Asn Leu Ala Glu Pro Asn Lys Glu Gly Trp Leu Pro Leu His Glu 
    130                 135                 140                 


Ala Ala Tyr Tyr Gly Gln Val Gly Cys Leu Lys Val Leu Gln Arg Ala 
145                 150                 155                 160 


Tyr Pro Gly Xaa Ile Asp Gln Arg Xaa Leu Gln Glu Glu Xaa Ala Val 
                165                 170                 175     


Tyr Leu Ala Xaa Cys Arg Gly His Leu Asp Cys Leu Leu Ser Leu Leu 
            180                 185                 190         


Gln Ala Gly Ala Glu Pro Asp Ile Ser Asn Lys Ser Arg Glu Xaa Pro 
        195                 200                 205             


Leu Tyr Lys Ala Cys Glu Arg Lys Asn Ala Glu Ala Val Lys Ile Leu 
    210                 215                 220                 


Val Gln His Asn Ala Asp Xaa Asn His Arg Cys Asn Arg Gly Trp Xaa 
225                 230                 235                 240 


Ala Leu His Glu Ser Val Ser Arg Asn Asp Leu Glu Val Met Gln Ile 
                245                 250                 255     


Leu Val Ser Gly Gly Ala Lys Val Glu Ser Lys Asn Ala Tyr Gly Ile 
            260                 265                 270         


Xaa Pro Leu Phe Val Ala Ala Gln Ser Gly Gln Leu Glu Ala Leu Arg 
        275                 280                 285             


Phe Leu Ala Lys Tyr Gly Ala Asp Ile Asn Xaa Gln Ala Ser Asp Asn 
    290                 295                 300                 


Ala Ser Ala Leu Tyr Glu Ala Cys Lys Asn Glu His Glu Glu Val Val 
305                 310                 315                 320 


Glu Phe Leu Leu Ser Gln Gly Ala Asp Ala Asn Lys Xaa Asn Lys Asp 
                325                 330                 335     


Gly Leu Leu Pro Leu His Ile Ala Ser Lys Lys Gly Asn Tyr Arg Ile 
            340                 345                 350         


Val Gln Met Leu Leu Pro Val Xaa Ser Arg Xaa Arg Ile Arg Arg Ser 
        355                 360                 365             


Gly Val Ser Pro Leu His Leu Ala Ala Glu Arg Asn His Asp Glu Val 
    370                 375                 380                 


Leu Glu Ala Leu Leu Ser Ala Arg Phe Asp Val Asn Xaa Pro Leu Ala 
385                 390                 395                 400 


Pro Glu Arg Ala Arg Leu Tyr Glu Asp Arg Arg Ser Ser Ala Leu Tyr 
                405                 410                 415     


Phe Ala Val Val Asn Asn Asn Val Tyr Ala Xaa Glu Leu Leu Leu Gln 
            420                 425                 430         


His Gly Ala Asp Pro Asn Arg Asp Val Ile Ser Pro Leu Leu Val Ala 
        435                 440                 445             


Ile Arg His Gly Cys Leu Arg Xaa Met Gln Leu Leu Leu Asp His Gly 
    450                 455                 460                 


Ala Asn Ile Asp Ala Tyr Ile Ala Xaa His Pro Xaa Ala Phe Pro Ala 
465                 470                 475                 480 


Xaa Ile Met Phe Ala Met Lys Cys Leu Ser Leu Leu Lys Phe Leu Met 
                485                 490                 495     


Asp Leu Gly Cys Asp Gly Glu Pro Cys Phe Ser Cys Leu Tyr Gly Asn 
            500                 505                 510         


Gly Pro His Pro Pro Ala Pro Gln Pro Ser Ser Arg Phe Asn Asp Ala 
        515                 520                 525             


Pro Ala Ala Asp Lys Glu Pro Ser Val Val Gln Phe Cys Glu Phe Val 
    530                 535                 540                 


Ser Ala Pro Glu Val Ser Arg Trp Ala Gly Pro Ile Ile Asp Val Leu 
545                 550                 555                 560 


Leu Asp Tyr Val Gly Asn Val Gln Leu Cys Ser Arg Leu Lys Glu His 
                565                 570                 575     


Ile Asp Ser Phe Glu Asp Trp Ala Val Ile Lys Glu Lys Ala Glu Pro 
            580                 585                 590         


Pro Arg Pro Leu Ala His Leu Cys Arg Leu Arg Val Arg Lys Ala Ile 
        595                 600                 605             


Gly Lys Tyr Arg Ile Lys Leu Leu Asp Xaa Leu Pro Leu Pro Gly Arg 
    610                 615                 620                 


Leu Ile Arg Tyr Leu Lys Tyr Glu Asn Xaa Gln 
625                 630                 635 


<210> 3361
<211> 112
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 3361
Met Gly Leu Phe Gln Gly Val Met Gln Lys Tyr Ser Ser Ser Leu Phe 
1               5                   10                  15      


Lys Xaa Ser Gln Leu Ala Pro Ala Asp Pro Leu Ile Lys Ala Ile Lys 
            20                  25                  30          


Asp Gly Asp Glu Glu Ala Leu Lys Xaa Met Ile Lys Glu Gly Lys Asn 
        35                  40                  45              


Leu Ala Glu Pro Asn Lys Glu Gly Trp Leu Pro Leu His Glu Ala Ala 
    50                  55                  60                  


Tyr Tyr Gly Gln Val Gly Cys Leu Lys Val Leu Gln Arg Ala Tyr Pro 
65                  70                  75                  80  


Gly Xaa Ile Asp Gln Arg Xaa Leu Gln Glu Glu Xaa Ala Val Tyr Leu 
                85                  90                  95      


Ala Xaa Cys Arg Gly His Leu Asp Cys Leu Leu Ser Leu Leu Gln Ala 
            100                 105                 110         


<210> 3362
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<400> 3362
Met Arg Pro Ala Asp Pro Leu Ile Lys Ala Ile Lys Asp Gly Asp Glu 
1               5                   10                  15      


Glu Ala Leu Lys Xaa Met Ile Lys Glu Gly Lys Asn Leu Ala Glu Pro 
            20                  25                  30          


Asn Lys Glu Gly Trp Leu Pro Leu His Glu Ala Ala Tyr Tyr Gly Gln 
        35                  40                  45              


Val Gly Cys Leu Lys Val Leu Gln Arg Ala Cys Glu Arg Lys Asn Ala 
    50                  55                  60                  


Glu Ala Val Lys Ile Leu Val Gln His Asn Ala Asp Xaa Asn His Arg 
65                  70                  75                  80  


Cys Asn Arg Gly Trp Xaa Ala Leu His Glu Ser Val Ser Arg Asn Asp 
                85                  90                  95      


Leu Glu Val Met Gln Ile Leu Val Ser Gly Gly Ala Lys Val Glu Ser 
            100                 105                 110         


Lys Asn Ala Tyr Gly Ile Xaa Pro Leu Phe Val Ala Ala Gln Ser Gly 
        115                 120                 125             


Gln Leu Glu Ala Leu Arg Phe 
    130                 135 


<210> 3363
<211> 481
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<400> 3363
Met Arg Pro Ala Asp Pro Leu Ile Lys Ala Ile Lys Asp Gly Asp Glu 
1               5                   10                  15      


Glu Ala Leu Lys Xaa Met Ile Lys Glu Gly Lys Asn Leu Ala Glu Pro 
            20                  25                  30          


Asn Lys Glu Gly Trp Leu Pro Leu His Glu Ala Ala Tyr Tyr Gly Gln 
        35                  40                  45              


Val Gly Cys Leu Lys Val Leu Gln Arg Ala Tyr Pro Gly Xaa Ile Asp 
    50                  55                  60                  


Gln Arg Xaa Leu Gln Glu Glu Xaa Ala Val Tyr Leu Ala Xaa Cys Arg 
65                  70                  75                  80  


Gly His Leu Asp Cys Leu Leu Ser Leu Leu Gln Ala Gly Ala Glu Pro 
                85                  90                  95      


Asp Ile Ser Asn Lys Ser Arg Glu Xaa Pro Leu Tyr Lys Ala Cys Glu 
            100                 105                 110         


Arg Lys Asn Ala Glu Ala Val Lys Ile Leu Val Gln His Asn Ala Asp 
        115                 120                 125             


Xaa Asn His Arg Cys Asn Arg Gly Trp Xaa Ala Leu His Glu Ser Val 
    130                 135                 140                 


Ser Arg Asn Asp Leu Glu Val Met Gln Ile Leu Val Ser Gly Gly Ala 
145                 150                 155                 160 


Lys Val Glu Ser Lys Asn Ala Tyr Gly Ile Xaa Pro Leu Phe Val Ala 
                165                 170                 175     


Ala Gln Ser Gly Gln Leu Glu Ala Leu Arg Phe Leu Ala Lys Tyr Gly 
            180                 185                 190         


Ala Asp Ile Asn Xaa Gln Ala Ser Asp Asn Ala Ser Ala Leu Tyr Glu 
        195                 200                 205             


Ala Cys Lys Asn Glu His Glu Glu Val Val Glu Phe Leu Leu Ser Gln 
    210                 215                 220                 


Gly Ala Asp Ala Asn Lys Xaa Asn Lys Asp Gly Leu Leu Pro Leu His 
225                 230                 235                 240 


Ile Ala Ser Lys Lys Gly Asn Tyr Arg Ile Val Gln Met Leu Leu Pro 
                245                 250                 255     


Val Xaa Ser Arg Xaa Arg Ile Arg Arg Ser Gly Val Ser Pro Leu His 
            260                 265                 270         


Leu Ala Ala Glu Arg Asn His Asp Glu Val Leu Glu Ala Leu Leu Ser 
        275                 280                 285             


Ala Arg Phe Asp Val Asn Xaa Pro Leu Ala Pro Glu Arg Ala Arg Leu 
    290                 295                 300                 


Tyr Glu Asp Arg Arg Ser Ser Ala Leu Tyr Phe Ala Val Val Asn Asn 
305                 310                 315                 320 


Asn Val Tyr Ala Xaa Glu Leu Leu Leu Gln His Gly Ala Asp Pro Asn 
                325                 330                 335     


Arg Asp Val Ile Ser Pro Leu Leu Val Ala Ile Arg His Gly Cys Leu 
            340                 345                 350         


Arg Xaa Met Gln Leu Leu Leu Asp His Gly Ala Asn Ile Asp Ala Tyr 
        355                 360                 365             


Ile Ala Xaa His Pro Xaa Ala Phe Pro Ala Xaa Ile Met Phe Ala Met 
    370                 375                 380                 


Lys Cys Leu Ser Leu Leu Lys Phe Leu Met Asp Leu Gly Cys Asp Gly 
385                 390                 395                 400 


Glu Pro Cys Phe Ser Cys Leu Tyr Gly Asn Gly Pro His Pro Pro Ala 
                405                 410                 415     


Pro Gln Pro Ser Ser Arg Phe Asn Asp Ala Pro Ala Ala Asp Lys Glu 
            420                 425                 430         


Pro Ser Val Val Gln Phe Cys Glu Phe Val Ser Ala Pro Glu Val Ser 
        435                 440                 445             


Arg Trp Ala Gly Pro Ile Ile Asp Val Leu Leu Asp Tyr Val Gly Asn 
    450                 455                 460                 


Val Gln Leu Cys Ser Arg Leu Lys Glu His Ile Asp Ser Phe Glu Asp 
465                 470                 475                 480 


Trp 
    


<210> 3364
<211> 587
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<400> 3364
Met Xaa Arg Phe Ser Tyr Ala Glu Tyr Phe Ser Leu Phe His Ser Cys 
1               5                   10                  15      


Ser Ala Pro Ser Arg Ser Xaa Ala Pro Pro Glu Ser Ser Pro Ala Arg 
            20                  25                  30          


Ala Pro Met Gly Leu Phe Gln Gly Val Met Gln Lys Tyr Ser Ser Ser 
        35                  40                  45              


Leu Phe Lys Xaa Ser Gln Leu Ala Pro Ala Asp Pro Leu Ile Lys Ala 
    50                  55                  60                  


Ile Lys Asp Gly Asp Glu Glu Ala Leu Lys Xaa Met Ile Lys Glu Gly 
65                  70                  75                  80  


Lys Asn Leu Ala Glu Pro Asn Lys Glu Gly Trp Leu Pro Leu His Glu 
                85                  90                  95      


Ala Ala Tyr Tyr Gly Gln Val Gly Cys Leu Lys Val Leu Gln Arg Ala 
            100                 105                 110         


Tyr Pro Gly Xaa Ile Asp Gln Arg Xaa Leu Gln Glu Glu Xaa Ala Val 
        115                 120                 125             


Tyr Leu Ala Xaa Cys Arg Gly His Leu Asp Cys Leu Leu Ser Leu Leu 
    130                 135                 140                 


Gln Ala Gly Ala Glu Pro Asp Ile Ser Asn Lys Ser Arg Glu Xaa Pro 
145                 150                 155                 160 


Leu Tyr Lys Ala Cys Glu Arg Lys Asn Ala Glu Ala Val Lys Ile Leu 
                165                 170                 175     


Val Gln His Asn Ala Asp Xaa Asn His Arg Cys Asn Arg Gly Trp Xaa 
            180                 185                 190         


Ala Leu His Glu Ser Val Ser Arg Asn Asp Leu Glu Val Met Gln Ile 
        195                 200                 205             


Leu Val Ser Gly Gly Ala Lys Val Glu Ser Lys Asn Ala Tyr Gly Ile 
    210                 215                 220                 


Xaa Pro Leu Phe Val Ala Ala Gln Ser Gly Gln Leu Glu Ala Leu Arg 
225                 230                 235                 240 


Phe Leu Ala Lys Tyr Gly Ala Asp Ile Asn Xaa Gln Ala Ser Asp Asn 
                245                 250                 255     


Ala Ser Ala Leu Tyr Glu Ala Cys Lys Asn Glu His Glu Glu Val Val 
            260                 265                 270         


Glu Phe Leu Leu Ser Gln Gly Ala Asp Ala Asn Lys Xaa Asn Lys Asp 
        275                 280                 285             


Gly Leu Leu Pro Leu His Ile Ala Ser Lys Lys Gly Asn Tyr Arg Ile 
    290                 295                 300                 


Val Gln Met Leu Leu Pro Val Xaa Ser Arg Xaa Arg Ile Arg Arg Ser 
305                 310                 315                 320 


Gly Val Ser Pro Leu His Leu Ala Ala Glu Arg Asn His Asp Glu Val 
                325                 330                 335     


Leu Glu Ala Leu Leu Ser Ala Arg Phe Asp Val Asn Xaa Pro Leu Ala 
            340                 345                 350         


Pro Glu Arg Ala Arg Leu Tyr Glu Asp Arg Arg Ser Ser Ala Leu Tyr 
        355                 360                 365             


Phe Ala Val Val Asn Asn Asn Val Tyr Ala Xaa Glu Leu Leu Leu Gln 
    370                 375                 380                 


His Gly Ala Asp Pro Asn Arg Asp Val Ile Ser Pro Leu Leu Val Ala 
385                 390                 395                 400 


Ile Arg His Gly Cys Leu Arg Xaa Met Gln Leu Leu Leu Asp His Gly 
                405                 410                 415     


Ala Asn Ile Asp Ala Tyr Ile Ala Xaa His Pro Xaa Ala Phe Pro Ala 
            420                 425                 430         


Xaa Ile Met Phe Ala Met Lys Cys Leu Ser Leu Leu Lys Phe Leu Met 
        435                 440                 445             


Asp Leu Gly Cys Asp Gly Glu Pro Cys Phe Ser Cys Leu Tyr Gly Asn 
    450                 455                 460                 


Gly Pro His Pro Pro Ala Pro Gln Pro Ser Ser Arg Phe Asn Asp Ala 
465                 470                 475                 480 


Pro Ala Ala Asp Lys Glu Pro Ser Val Val Gln Phe Cys Glu Phe Val 
                485                 490                 495     


Ser Ala Pro Glu Val Ser Arg Trp Ala Gly Pro Ile Ile Asp Val Leu 
            500                 505                 510         


Leu Asp Tyr Val Gly Asn Val Gln Leu Cys Ser Arg Leu Lys Glu His 
        515                 520                 525             


Ile Asp Ser Phe Glu Asp Trp Ala Val Ile Lys Glu Lys Ala Glu Pro 
    530                 535                 540                 


Pro Arg Pro Leu Ala His Leu Cys Arg Leu Arg Val Arg Lys Ala Ile 
545                 550                 555                 560 


Gly Lys Tyr Arg Ile Lys Leu Leu Asp Xaa Leu Pro Leu Pro Gly Arg 
                565                 570                 575     


Leu Ile Arg Tyr Leu Lys Tyr Glu Asn Xaa Gln 
            580                 585         


<210> 3365
<211> 518
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<400> 3365
Met Asp Phe Xaa Glu Ala Tyr Ala Asp Xaa Cys Ser Xaa Val Gly Leu 
1               5                   10                  15      


Ala Ala Arg Glu Gly Asn Val Lys Val Leu Arg Lys Leu Leu Lys Lys 
            20                  25                  30          


Gly Arg Ser Val Asp Val Ala Asp Asn Arg Gly Trp Met Pro Ile His 
        35                  40                  45              


Glu Ala Ala Tyr His Asn Ser Val Glu Cys Leu Gln Met Leu Ile Asn 
    50                  55                  60                  


Ala Asp Ser Ser Glu Asn Tyr Ile Lys Met Lys Xaa Phe Glu Gly Phe 
65                  70                  75                  80  


Cys Ala Leu His Leu Ala Ala Ser Gln Gly His Trp Lys Ile Val Gln 
                85                  90                  95      


Ile Leu Leu Glu Ala Gly Ala Asp Pro Asn Ala Xaa Xaa Leu Glu Glu 
            100                 105                 110         


Xaa Xaa Pro Leu Phe Leu Ala Val Glu Asn Gly Gln Ile Asp Val Leu 
        115                 120                 125             


Arg Leu Leu Leu Gln His Gly Ala Asn Val Asn Gly Ser His Ser Met 
    130                 135                 140                 


Cys Gly Trp Asn Ser Leu His Gln Ala Ser Phe Gln Glu Asn Ala Glu 
145                 150                 155                 160 


Ile Ile Lys Leu Leu Leu Arg Lys Gly Ala Asn Lys Glu Cys Gln Asp 
                165                 170                 175     


Asp Phe Gly Ile Xaa Pro Leu Phe Val Ala Ala Gln Tyr Gly Lys Leu 
            180                 185                 190         


Glu Ser Leu Ser Ile Leu Ile Ser Ser Gly Ala Asn Val Asn Cys Gln 
        195                 200                 205             


Ala Leu Asp Lys Ala Xaa Pro Leu Phe Ile Ala Ala Gln Glu Gly His 
    210                 215                 220                 


Xaa Lys Cys Val Glu Leu Leu Leu Ser Ser Gly Ala Asp Pro Asp Leu 
225                 230                 235                 240 


Tyr Cys Asn Glu Asp Ser Trp Gln Leu Pro Ile His Ala Ala Ala Gln 
                245                 250                 255     


Met Gly His Xaa Lys Ile Leu Asp Leu Leu Ile Pro Leu Xaa Asn Arg 
            260                 265                 270         


Ala Cys Asp Xaa Gly Leu Asn Lys Val Ser Pro Val Tyr Ser Ala Val 
        275                 280                 285             


Phe Gly Gly His Glu Asp Cys Leu Glu Ile Leu Leu Arg Asn Gly Tyr 
    290                 295                 300                 


Ser Pro Asp Ala Gln Ala Cys Leu Val Phe Gly Phe Ser Ser Pro Val 
305                 310                 315                 320 


Cys Met Ala Phe Gln Lys Asp Cys Glu Phe Phe Gly Ile Val Asn Ile 
                325                 330                 335     


Leu Leu Lys Tyr Gly Ala Gln Ile Asn Glu Leu His Leu Ala Tyr Cys 
            340                 345                 350         


Leu Lys Tyr Glu Lys Phe Ser Ile Phe Arg Tyr Phe Leu Arg Lys Gly 
        355                 360                 365             


Cys Ser Leu Gly Pro Trp Asn His Ile Tyr Glu Phe Val Asn His Ala 
    370                 375                 380                 


Ile Lys Ala Gln Ala Lys Tyr Lys Glu Trp Leu Pro His Leu Leu Val 
385                 390                 395                 400 


Ala Gly Phe Asp Pro Leu Ile Leu Leu Cys Asn Ser Trp Ile Asp Ser 
                405                 410                 415     


Val Ser Ile Asp Xaa Leu Ile Phe Xaa Leu Glu Phe Xaa Asn Trp Lys 
            420                 425                 430         


Xaa Leu Ala Pro Ala Val Glu Arg Met Leu Ser Ala Arg Ala Ser Asn 
        435                 440                 445             


Ala Trp Ile Leu Gln Gln His Ile Ala Xaa Val Pro Ser Leu Xaa His 
    450                 455                 460                 


Leu Cys Arg Leu Glu Ile Arg Ser Ser Leu Lys Ser Glu Arg Leu Arg 
465                 470                 475                 480 


Ser Asp Ser Tyr Ile Ser Gln Leu Pro Leu Pro Arg Ser Leu His Asn 
                485                 490                 495     


Tyr Leu Leu Tyr Glu Asp Val Leu Arg Met Tyr Glu Val Pro Glu Leu 
            500                 505                 510         


Ala Ala Ile Gln Asp Gly 
        515             


<210> 3366
<211> 445
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<400> 3366
Met Lys Xaa Phe Glu Gly Phe Cys Ala Leu His Leu Ala Ala Ser Gln 
1               5                   10                  15      


Gly His Trp Lys Ile Val Gln Ile Leu Leu Glu Ala Gly Ala Asp Pro 
            20                  25                  30          


Asn Ala Xaa Xaa Leu Glu Glu Xaa Xaa Pro Leu Phe Leu Ala Val Glu 
        35                  40                  45              


Asn Gly Gln Ile Asp Val Leu Arg Leu Leu Leu Gln His Gly Ala Asn 
    50                  55                  60                  


Val Asn Gly Ser His Ser Met Cys Gly Trp Asn Ser Leu His Gln Ala 
65                  70                  75                  80  


Ser Phe Gln Glu Asn Ala Glu Ile Ile Lys Leu Leu Leu Arg Lys Gly 
                85                  90                  95      


Ala Asn Lys Glu Cys Gln Asp Asp Phe Gly Ile Xaa Pro Leu Phe Val 
            100                 105                 110         


Ala Ala Gln Tyr Gly Lys Leu Glu Ser Leu Ser Ile Leu Ile Ser Ser 
        115                 120                 125             


Gly Ala Asn Val Asn Cys Gln Ala Leu Asp Lys Ala Xaa Pro Leu Phe 
    130                 135                 140                 


Ile Ala Ala Gln Glu Gly His Xaa Lys Cys Val Glu Leu Leu Leu Ser 
145                 150                 155                 160 


Ser Gly Ala Asp Pro Asp Leu Tyr Cys Asn Glu Asp Ser Trp Gln Leu 
                165                 170                 175     


Pro Ile His Ala Ala Ala Gln Met Gly His Xaa Lys Ile Leu Asp Leu 
            180                 185                 190         


Leu Ile Pro Leu Xaa Asn Arg Ala Cys Asp Xaa Gly Leu Asn Lys Val 
        195                 200                 205             


Ser Pro Val Tyr Ser Ala Val Phe Gly Gly His Glu Asp Cys Leu Glu 
    210                 215                 220                 


Ile Leu Leu Arg Asn Gly Tyr Ser Pro Asp Ala Gln Ala Cys Leu Val 
225                 230                 235                 240 


Phe Gly Phe Ser Ser Pro Val Cys Met Ala Phe Gln Lys Asp Cys Glu 
                245                 250                 255     


Phe Phe Gly Ile Val Asn Ile Leu Leu Lys Tyr Gly Ala Gln Ile Asn 
            260                 265                 270         


Glu Leu His Leu Ala Tyr Cys Leu Lys Tyr Glu Lys Phe Ser Ile Phe 
        275                 280                 285             


Arg Tyr Phe Leu Arg Lys Gly Cys Ser Leu Gly Pro Trp Asn His Ile 
    290                 295                 300                 


Tyr Glu Phe Val Asn His Ala Ile Lys Ala Gln Ala Lys Tyr Lys Glu 
305                 310                 315                 320 


Trp Leu Pro His Leu Leu Val Ala Gly Phe Asp Pro Leu Ile Leu Leu 
                325                 330                 335     


Cys Asn Ser Trp Ile Asp Ser Val Ser Ile Asp Xaa Leu Ile Phe Xaa 
            340                 345                 350         


Leu Glu Phe Xaa Asn Trp Lys Xaa Leu Ala Pro Ala Val Glu Arg Met 
        355                 360                 365             


Leu Ser Ala Arg Ala Ser Asn Ala Trp Ile Leu Gln Gln His Ile Ala 
    370                 375                 380                 


Xaa Val Pro Ser Leu Xaa His Leu Cys Arg Leu Glu Ile Arg Ser Ser 
385                 390                 395                 400 


Leu Lys Ser Glu Arg Leu Arg Ser Asp Ser Tyr Ile Ser Gln Leu Pro 
                405                 410                 415     


Leu Pro Arg Ser Leu His Asn Tyr Leu Leu Tyr Glu Asp Val Leu Arg 
            420                 425                 430         


Met Tyr Glu Val Pro Glu Leu Ala Ala Ile Gln Asp Gly 
        435                 440                 445 


<210> 3367
<211> 477
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<400> 3367
Xaa Asp Xaa Cys Ser Xaa Val Gly Leu Ala Ala Arg Glu Gly Asn Val 
1               5                   10                  15      


Lys Val Leu Arg Lys Leu Leu Lys Lys Gly Arg Ser Val Asp Val Ala 
            20                  25                  30          


Asp Asn Arg Gly Trp Met Pro Ile His Glu Ala Ala Tyr His Asn Ser 
        35                  40                  45              


Val Glu Cys Leu Gln Met Leu Ile Asn Ala Asp Ser Ser Glu Asn Tyr 
    50                  55                  60                  


Ile Lys Met Lys Xaa Phe Glu Gly Phe Cys Ala Leu His Leu Ala Ala 
65                  70                  75                  80  


Ser Gln Gly His Trp Lys Ile Val Gln Ile Leu Leu Glu Ala Gly Ala 
                85                  90                  95      


Asp Pro Asn Ala Xaa Xaa Leu Glu Glu Xaa Xaa Pro Leu Phe Leu Ala 
            100                 105                 110         


Val Glu Asn Gly Gln Ile Asp Val Leu Arg Leu Leu Leu Gln His Gly 
        115                 120                 125             


Ala Asn Val Asn Gly Ser His Ser Met Cys Gly Trp Asn Ser Leu His 
    130                 135                 140                 


Gln Ala Ser Phe Gln Glu Asn Ala Glu Ile Ile Lys Leu Leu Leu Arg 
145                 150                 155                 160 


Lys Gly Ala Asn Lys Glu Cys Gln Asp Asp Phe Gly Ile Xaa Pro Leu 
                165                 170                 175     


Phe Val Ala Ala Gln Tyr Gly Lys Leu Glu Ser Leu Ser Ile Leu Ile 
            180                 185                 190         


Ser Ser Gly Ala Asn Val Asn Cys Gln Ala Leu Asp Lys Ala Xaa Pro 
        195                 200                 205             


Leu Phe Ile Ala Ala Gln Glu Gly His Xaa Lys Cys Val Glu Leu Leu 
    210                 215                 220                 


Leu Ser Ser Gly Ala Asp Pro Asp Leu Tyr Cys Asn Glu Asp Ser Trp 
225                 230                 235                 240 


Gln Leu Pro Ile His Ala Ala Ala Gln Met Gly His Xaa Lys Ile Leu 
                245                 250                 255     


Asp Leu Leu Ile Pro Leu Xaa Asn Arg Ala Cys Asp Xaa Gly Leu Asn 
            260                 265                 270         


Lys Val Ser Pro Val Tyr Ser Ala Val Phe Gly Gly His Glu Asp Cys 
        275                 280                 285             


Leu Glu Ile Leu Leu Arg Asn Gly Tyr Ser Pro Asp Ala Gln Ala Cys 
    290                 295                 300                 


Leu Val Phe Gly Phe Ser Ser Pro Val Cys Met Ala Phe Gln Lys Asp 
305                 310                 315                 320 


Cys Glu Phe Phe Gly Ile Val Asn Ile Leu Leu Lys Tyr Gly Ala Gln 
                325                 330                 335     


Ile Asn Glu Leu His Leu Ala Tyr Cys Leu Lys Tyr Glu Lys Phe Ser 
            340                 345                 350         


Ile Phe Arg Tyr Phe Leu Arg Lys Gly Cys Ser Leu Gly Pro Trp Asn 
        355                 360                 365             


His Ile Tyr Glu Phe Val Asn His Ala Ile Lys Ala Gln Ala Lys Tyr 
    370                 375                 380                 


Lys Glu Trp Leu Pro His Leu Leu Val Ala Gly Phe Asp Pro Leu Ile 
385                 390                 395                 400 


Leu Leu Cys Asn Ser Trp Ile Asp Ser Val Ser Ile Asp Xaa Leu Ile 
                405                 410                 415     


Phe Xaa Leu Glu Phe Xaa Asn Trp Lys Xaa Leu Ala Pro Ala Val Glu 
            420                 425                 430         


Arg Met Leu Ser Ala Arg Ala Ser Asn Ala Trp Ile Leu Gln Gln His 
        435                 440                 445             


Ile Glu Gln Gly Phe Ile Leu Gln Lys Tyr Leu Gly Pro Ser Asn Ser 
    450                 455                 460                 


Gln Val Asp Phe Leu Leu Arg Gly Glu Leu Pro Ile Gly 
465                 470                 475         


<210> 3368
<211> 349
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<400> 3368
Met Asp Gly Xaa Xaa Ala Pro Val Xaa Lys Ser Gly Ala Ala Lys Leu 
1               5                   10                  15      


Val Lys Arg Asn Phe Leu Glu Ala Leu Lys Ser Asn Asp Phe Gly Lys 
            20                  25                  30          


Leu Lys Ala Ile Leu Ile Gln Arg Gln Ile Asp Val Asp Xaa Val Phe 
        35                  40                  45              


Glu Val Glu Asp Glu Asn Met Val Leu Ala Ser Tyr Lys Gln Gly Tyr 
    50                  55                  60                  


Trp Leu Pro Ser Tyr Lys Leu Lys Ser Ser Trp Ala Xaa Gly Leu His 
65                  70                  75                  80  


Leu Ser Val Leu Phe Gly His Val Glu Cys Leu Leu Val Leu Leu Asp 
                85                  90                  95      


His Asn Ala Xaa Ile Asn Cys Arg Pro Asn Gly Lys Xaa Pro Leu His 
            100                 105                 110         


Val Ala Cys Glu Met Ala Asn Val Asp Cys Val Lys Ile Leu Cys Asp 
        115                 120                 125             


Arg Gly Ala Lys Leu Asn Cys Tyr Ser Leu Ser Gly His Xaa Ala Leu 
    130                 135                 140                 


His Phe Cys Xaa Xaa Pro Ser Ser Ile Leu Cys Ala Lys Gln Leu Val 
145                 150                 155                 160 


Trp Arg Gly Ala Asn Val Asn Met Lys Xaa Asn Asn Gln Asp Glu Glu 
                165                 170                 175     


Xaa Pro Leu His Xaa Ala Ala His Phe Gly Leu Ser Glu Leu Val Ala 
            180                 185                 190         


Phe Tyr Val Glu His Gly Ala Ile Val Asp Ser Val Asn Ala His Met 
        195                 200                 205             


Glu Xaa Pro Leu Ala Ile Ala Ala Tyr Trp Ala Leu Arg Phe Lys Glu 
    210                 215                 220                 


Gln Glu Tyr Ser Xaa Glu His His Leu Val Cys Arg Met Leu Leu Asp 
225                 230                 235                 240 


Tyr Lys Ala Glu Val Asn Ala Arg Asp Asp Asp Phe Lys Ser Pro Leu 
                245                 250                 255     


His Lys Ala Ala Trp Asn Cys Asp His Val Leu Met His Met Met Leu 
            260                 265                 270         


Glu Ala Gly Ala Glu Ala Asn Leu Met Asp Ile Asn Gly Cys Ala Ala 
        275                 280                 285             


Ile Gln Tyr Val Leu Lys Val Xaa Ser Val Arg Pro Ala Ala Gln Pro 
    290                 295                 300                 


Glu Ile Cys Tyr Gln Leu Leu Leu Asn His Gly Ala Ala Arg Ile Tyr 
305                 310                 315                 320 


Pro Pro Gln Phe His Lys Val Arg Leu Cys Pro Val Val Ser Arg Leu 
                325                 330                 335     


Arg Lys Ile Gln Met Ala Ala Leu Ser Glu Ile Ser Lys 
            340                 345                 


<210> 3369
<211> 426
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<400> 3369
Met Asp Gly Xaa Xaa Ala Pro Val Xaa Lys Ser Gly Ala Ala Lys Leu 
1               5                   10                  15      


Val Lys Arg Asn Phe Leu Glu Ala Leu Lys Ser Asn Asp Phe Gly Lys 
            20                  25                  30          


Leu Lys Ala Ile Leu Ile Gln Arg Gln Ile Asp Val Asp Xaa Val Phe 
        35                  40                  45              


Glu Val Glu Asp Glu Asn Met Val Leu Ala Ser Tyr Lys Gln Gly Tyr 
    50                  55                  60                  


Trp Leu Pro Ser Tyr Lys Leu Lys Ser Ser Trp Ala Xaa Gly Leu His 
65                  70                  75                  80  


Leu Ser Val Leu Phe Gly His Val Glu Cys Leu Leu Val Leu Leu Asp 
                85                  90                  95      


His Asn Ala Xaa Ile Asn Cys Arg Pro Asn Gly Lys Xaa Pro Leu His 
            100                 105                 110         


Val Ala Cys Glu Met Ala Asn Val Asp Cys Val Lys Ile Leu Cys Asp 
        115                 120                 125             


Arg Gly Ala Lys Leu Asn Cys Tyr Ser Leu Ser Gly His Xaa Ala Leu 
    130                 135                 140                 


His Phe Cys Xaa Xaa Pro Ser Ser Ile Leu Cys Ala Lys Gln Leu Val 
145                 150                 155                 160 


Trp Arg Gly Ala Asn Val Asn Met Lys Xaa Asn Asn Gln Asp Glu Glu 
                165                 170                 175     


Xaa Pro Leu His Xaa Ala Ala His Phe Gly Leu Ser Glu Leu Val Ala 
            180                 185                 190         


Phe Tyr Val Glu His Gly Ala Ile Val Asp Ser Val Asn Ala His Met 
        195                 200                 205             


Glu Xaa Pro Leu Ala Ile Ala Ala Tyr Trp Ala Leu Arg Phe Lys Glu 
    210                 215                 220                 


Gln Glu Tyr Ser Xaa Glu His His Leu Val Cys Arg Met Leu Leu Asp 
225                 230                 235                 240 


Tyr Lys Ala Glu Val Asn Ala Arg Asp Asp Asp Phe Lys Ser Pro Leu 
                245                 250                 255     


His Lys Ala Ala Trp Asn Cys Asp His Val Leu Met His Met Met Leu 
            260                 265                 270         


Glu Ala Gly Ala Glu Ala Asn Leu Met Asp Ile Asn Gly Cys Ala Ala 
        275                 280                 285             


Ile Gln Tyr Val Leu Lys Val Xaa Ser Val Arg Pro Ala Ala Gln Pro 
    290                 295                 300                 


Glu Ile Cys Tyr Gln Leu Leu Leu Asn His Gly Ala Ala Arg Ile Tyr 
305                 310                 315                 320 


Pro Pro Gln Phe His Lys Val Ile Gln Ala Cys His Ser Cys Pro Lys 
                325                 330                 335     


Ala Ile Glu Val Val Val Asn Ala Tyr Glu His Ile Arg Trp Asn Xaa 
            340                 345                 350         


Lys Trp Arg Arg Ala Ile Pro Asp Asp Asp Leu Glu Lys Tyr Trp Asp 
        355                 360                 365             


Phe Tyr His Ser Leu Phe Xaa Val Cys Cys Asn Ser Pro Arg Xaa Leu 
    370                 375                 380                 


Met His Leu Ser Arg Cys Ala Ile Arg Arg Xaa Leu His Asn Arg Cys 
385                 390                 395                 400 


His Arg Ala Ile Pro Leu Leu Ser Leu Pro Leu Ser Leu Lys Lys Tyr 
                405                 410                 415     


Leu Leu Leu Glu Pro Glu Gly Ile Ile Tyr 
            420                 425     


<210> 3370
<211> 276
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<400> 3370
Met Pro Leu Cys Asn Gly Gly Asn Leu Ala Val Xaa Gly Ser Trp Ala 
1               5                   10                  15      


Asp Arg Ser Pro Leu His Glu Ala Ala Ser Gln Gly Arg Leu Leu Ala 
            20                  25                  30          


Leu Arg Xaa Leu Leu Ser Gln Gly Tyr Asn Val Asn Ala Val Xaa Leu 
        35                  40                  45              


Asp His Val Xaa Pro Leu His Glu Ala Cys Leu Gly Asp His Val Ala 
    50                  55                  60                  


Cys Ala Arg Xaa Leu Leu Glu Ala Gly Ala Asn Val Asn Ala Ile Xaa 
65                  70                  75                  80  


Ile Asp Gly Val Xaa Pro Leu Phe Asn Ala Cys Ser Gln Gly Ser Pro 
                85                  90                  95      


Ser Cys Ala Glu Leu Leu Leu Glu Tyr Gly Ala Lys Ala Gln Leu Glu 
            100                 105                 110         


Ser Cys Leu Pro Ser Pro Xaa His Glu Ala Ala Ser Lys Gly His His 
        115                 120                 125             


Glu Cys Leu Asp Ile Leu Ile Ser Trp Gly Ile Asp Val Asp Gln Glu 
    130                 135                 140                 


Ile Pro His Leu Gly Xaa Pro Leu Tyr Val Ala Cys Met Ser Gln Gln 
145                 150                 155                 160 


Phe His Cys Ile Trp Lys Leu Leu Tyr Ala Gly Ala Asp Val Gln Lys 
                165                 170                 175     


Gly Lys Tyr Trp Asp Xaa Pro Leu His Ala Ala Ala Gln Gln Ser Ser 
            180                 185                 190         


Xaa Glu Ile Val Asn Leu Leu Leu Glu Phe Gly Ala Asp Ile Asn Ala 
        195                 200                 205             


Lys Asn Xaa Glu Leu Leu Arg Pro Ile Asp Val Ala Xaa Ser Ser Ser 
    210                 215                 220                 


Met Val Glu Arg Ile Leu Leu Gln His Glu Ala Xaa Pro Ser Ser Leu 
225                 230                 235                 240 


Tyr Gln Leu Cys Arg Leu Cys Ile Arg Ser Tyr Ile Gly Lys Pro Arg 
                245                 250                 255     


Leu His Leu Ile Pro Gln Leu Gln Leu Pro Xaa Leu Leu Lys Asn Phe 
            260                 265                 270         


Leu Gln Tyr Arg 
        275     


<210> 3371
<211> 20
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<400> 3371
Met Ser Val Leu Glu Glu Asn Arg Pro Phe Ala Gln Gln Leu Ser Asn 
1               5                   10                  15      


Val Tyr Phe Xaa 
            20  


<210> 3372
<211> 329
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<400> 3372
Met Ser Val Leu Glu Glu Asn Arg Pro Phe Ala Gln Gln Leu Ser Asn 
1               5                   10                  15      


Val Tyr Phe Xaa Ile Leu Ser Leu Phe Cys Phe Lys Leu Phe Val Lys 
            20                  25                  30          


Ile Ser Leu Ala Ile Leu Ser His Phe Tyr Ile Val Lys Gly Asn Arg 
        35                  40                  45              


Lys Glu Ala Ala Arg Ile Ala Ala Glu Phe Tyr Gly Val Xaa Gln Gly 
    50                  55                  60                  


Gln Gly Ser Trp Ala Asp Arg Ser Pro Leu His Glu Ala Ala Ser Gln 
65                  70                  75                  80  


Gly Arg Leu Leu Ala Leu Arg Xaa Leu Leu Ser Gln Gly Tyr Asn Val 
                85                  90                  95      


Asn Ala Val Xaa Leu Asp His Val Xaa Pro Leu His Glu Ala Cys Leu 
            100                 105                 110         


Gly Asp His Val Ala Cys Ala Arg Xaa Leu Leu Glu Ala Gly Ala Asn 
        115                 120                 125             


Val Asn Ala Ile Xaa Ile Asp Gly Val Xaa Pro Leu Phe Asn Ala Cys 
    130                 135                 140                 


Ser Gln Gly Ser Pro Ser Cys Ala Glu Leu Leu Leu Glu Tyr Gly Ala 
145                 150                 155                 160 


Lys Ala Gln Leu Glu Ser Cys Leu Pro Ser Pro Xaa His Glu Ala Ala 
                165                 170                 175     


Ser Lys Gly His His Glu Cys Leu Asp Ile Leu Ile Ser Trp Gly Ile 
            180                 185                 190         


Asp Val Asp Gln Glu Ile Pro His Leu Gly Xaa Pro Leu Tyr Val Ala 
        195                 200                 205             


Cys Met Ser Gln Gln Phe His Cys Ile Trp Lys Leu Leu Tyr Ala Gly 
    210                 215                 220                 


Ala Asp Val Gln Lys Gly Lys Tyr Trp Asp Xaa Pro Leu His Ala Ala 
225                 230                 235                 240 


Ala Gln Gln Ser Ser Xaa Glu Ile Val Asn Leu Leu Leu Glu Phe Gly 
                245                 250                 255     


Ala Asp Ile Asn Ala Lys Asn Xaa Glu Leu Leu Arg Pro Ile Asp Val 
            260                 265                 270         


Ala Xaa Ser Ser Ser Met Val Glu Arg Ile Leu Leu Gln His Glu Ala 
        275                 280                 285             


Xaa Pro Ser Ser Leu Tyr Gln Leu Cys Arg Leu Cys Ile Arg Ser Tyr 
    290                 295                 300                 


Ile Gly Lys Pro Arg Leu His Leu Ile Pro Gln Leu Gln Leu Pro Xaa 
305                 310                 315                 320 


Leu Leu Lys Asn Phe Leu Gln Tyr Arg 
                325                 


<210> 3373
<211> 197
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<400> 3373
Met Pro Phe Leu His Gly Phe Arg Arg Ile Ile Phe Glu Tyr Gln Pro 
1               5                   10                  15      


Leu Val Asp Ala Ile Leu Gly Ser Leu Gly Ile Gln Asp Pro Glu Arg 
            20                  25                  30          


Gln Glu Ser Leu Asp Arg Pro Ser Tyr Val Ala Ser Glu Glu Ser Arg 
        35                  40                  45              


Ile Leu Val Leu Xaa Glu Leu Leu Glu Arg Lys Ala His Ser Pro Phe 
    50                  55                  60                  


Tyr Gln Glu Gly Val Ser Asn Ala Leu Leu Lys Met Ala Glu Leu Gly 
65                  70                  75                  80  


Leu Xaa Arg Ala Ala Asp Val Leu Leu Arg His Gly Ala Asn Leu Asn 
                85                  90                  95      


Phe Glu Asp Pro Val Xaa Tyr Tyr Xaa Ala Leu His Ile Ala Val Leu 
            100                 105                 110         


Arg Asn Gln Pro Asp Met Val Glu Leu Leu Val His His Gly Ala Asp 
        115                 120                 125             


Val Asn Arg Arg Asp Arg Glu Lys Leu Leu Cys Ser Met Leu Trp Pro 
    130                 135                 140                 


Ala Ala Xaa Gly Cys Arg Ser Xaa Ile Leu Arg Xaa Phe Val Ser Tyr 
145                 150                 155                 160 


Trp Lys Glu Gly Gln Xaa Ser Arg Pro Pro Pro Lys Met Gly Xaa Gln 
                165                 170                 175     


Cys Ser Pro Ala Ser Ser Ser Cys Leu Val Arg Pro Trp Glu Gly Xaa 
            180                 185                 190         


Lys Arg Arg Pro Arg 
        195         


<210> 3374
<211> 392
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<400> 3374
Met Pro Phe Leu His Gly Phe Arg Arg Ile Ile Phe Glu Tyr Gln Pro 
1               5                   10                  15      


Leu Val Asp Ala Ile Leu Gly Ser Leu Gly Ile Gln Asp Pro Glu Arg 
            20                  25                  30          


Gln Glu Ser Leu Asp Arg Pro Ser Tyr Val Ala Ser Glu Glu Ser Arg 
        35                  40                  45              


Ile Leu Val Leu Xaa Glu Leu Leu Glu Arg Lys Ala His Ser Pro Phe 
    50                  55                  60                  


Tyr Gln Glu Gly Val Ser Asn Ala Leu Leu Lys Met Ala Glu Leu Gly 
65                  70                  75                  80  


Leu Xaa Arg Ala Ala Asp Val Leu Leu Arg His Gly Ala Asn Leu Asn 
                85                  90                  95      


Phe Glu Asp Pro Val Xaa Tyr Tyr Xaa Ala Leu His Ile Ala Val Leu 
            100                 105                 110         


Arg Asn Gln Pro Asp Met Val Glu Leu Leu Val His His Gly Ala Asp 
        115                 120                 125             


Val Asn Arg Arg Asp Arg Ile His Glu Ser Ser Pro Leu Asp Leu Ala 
    130                 135                 140                 


Ser Glu Glu Pro Glu Arg Leu Pro Cys Leu Gln Arg Leu Leu Asp Leu 
145                 150                 155                 160 


Gly Ala Asp Val Asn Ala Ala Asp Lys His Gly Ala Asp Val Lys Ala 
                165                 170                 175     


Xaa Xaa Lys Asp Gly Asp Xaa Val Phe Xaa Cys Ile Ile Phe Leu Leu 
            180                 185                 190         


Gly Glu Xaa Val Gly Gly Asp Lys Glu Glu Ala Gln Met Ile Asn Arg 
        195                 200                 205             


Phe Cys Phe Gln Val Xaa Arg Leu Leu Leu Ala His Gly Ala Asp Pro 
    210                 215                 220                 


Ser Glu Cys Pro Ala His Glu Ser Leu Xaa His Ile Cys Leu Lys Ser 
225                 230                 235                 240 


Phe Lys Leu His Phe Pro Leu Leu Arg Phe Leu Leu Glu Ser Gly Ala 
                245                 250                 255     


Ala Tyr Asn Cys Ser Leu His Gly Ala Ser Cys Trp Ser Gly Phe His 
            260                 265                 270         


Ile Ile Phe Glu Arg Leu Cys Ser His Pro Gly Cys Xaa Glu Asp Glu 
        275                 280                 285             


Ser His Ala Asp Leu Leu Arg Lys Ala Glu Xaa Val Leu Asp Leu Met 
    290                 295                 300                 


Val Xaa Asn Ser Gln Lys Leu Gln Leu Pro Glu Asn Phe Asp Ile His 
305                 310                 315                 320 


Pro Val Gly Ser Leu Ala Glu Lys Ile Gln Ala Leu His Phe Ser Leu 
                325                 330                 335     


Arg Gln Leu Glu Ser Tyr Pro Pro Pro Leu Lys His Leu Cys Arg Val 
            340                 345                 350         


Ala Ile Arg Leu Tyr Leu Gln Pro Trp Pro Val Asp Val Lys Val Lys 
        355                 360                 365             


Ala Leu Pro Leu Pro Asp Arg Leu Lys Trp Tyr Leu Leu Ser Glu His 
    370                 375                 380                 


Ser Gly Ser Val Glu Asp Asp Ile 
385                 390         


<210> 3375
<211> 421
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<400> 3375
Met Pro Phe Leu His Gly Phe Arg Arg Ile Ile Phe Glu Tyr Gln Pro 
1               5                   10                  15      


Leu Val Asp Ala Ile Leu Gly Ser Leu Gly Ile Gln Asp Pro Glu Arg 
            20                  25                  30          


Gln Glu Ser Leu Asp Arg Pro Ser Tyr Val Ala Ser Glu Glu Ser Arg 
        35                  40                  45              


Ile Leu Val Leu Xaa Glu Leu Leu Glu Arg Lys Ala His Ser Pro Phe 
    50                  55                  60                  


Tyr Gln Glu Gly Val Ser Asn Ala Leu Leu Lys Met Ala Glu Leu Gly 
65                  70                  75                  80  


Leu Xaa Arg Ala Ala Asp Val Leu Leu Arg His Gly Ala Asn Leu Asn 
                85                  90                  95      


Phe Glu Asp Pro Val Xaa Tyr Tyr Xaa Ala Leu His Ile Ala Val Leu 
            100                 105                 110         


Arg Asn Gln Pro Asp Met Val Glu Leu Leu Val His His Gly Ala Asp 
        115                 120                 125             


Val Asn Arg Arg Asp Arg Ile His Glu Ser Ser Pro Leu Asp Leu Ala 
    130                 135                 140                 


Ser Glu Glu Pro Glu Arg Leu Pro Cys Leu Gln Arg Leu Leu Asp Leu 
145                 150                 155                 160 


Gly Ala Asp Val Asn Ala Ala Asp Lys His Gly Lys Xaa Ala Leu Leu 
                165                 170                 175     


His Ala Leu Ala Ser Ser Asp Gly Val Gln Ile His Asn Xaa Glu Asn 
            180                 185                 190         


Ile Arg Leu Leu Leu Glu Gly Gly Ala Asp Val Lys Ala Xaa Xaa Lys 
        195                 200                 205             


Asp Gly Asp Xaa Val Phe Xaa Cys Ile Ile Phe Leu Leu Gly Glu Xaa 
    210                 215                 220                 


Val Gly Gly Asp Lys Glu Glu Ala Gln Met Ile Asn Arg Phe Cys Phe 
225                 230                 235                 240 


Gln Val Xaa Arg Leu Leu Leu Ala His Gly Ala Asp Pro Ser Glu Cys 
                245                 250                 255     


Pro Ala His Glu Ser Leu Xaa His Ile Cys Leu Lys Ser Phe Lys Leu 
            260                 265                 270         


His Phe Pro Leu Leu Arg Phe Leu Leu Glu Ser Gly Ala Ala Tyr Asn 
        275                 280                 285             


Cys Ser Leu His Gly Ala Ser Cys Trp Ser Gly Phe His Ile Ile Phe 
    290                 295                 300                 


Glu Arg Leu Cys Ser His Pro Gly Cys Xaa Glu Asp Glu Ser His Ala 
305                 310                 315                 320 


Asp Leu Leu Arg Lys Ala Glu Xaa Val Leu Asp Leu Met Val Xaa Asn 
                325                 330                 335     


Ser Gln Lys Leu Gln Leu Pro Glu Asn Phe Asp Ile His Pro Val Gly 
            340                 345                 350         


Ser Leu Ala Glu Lys Ile Gln Ala Leu His Phe Ser Leu Arg Gln Leu 
        355                 360                 365             


Glu Ser Tyr Pro Pro Pro Leu Lys His Leu Cys Arg Val Ala Ile Arg 
    370                 375                 380                 


Leu Tyr Leu Gln Pro Trp Pro Val Asp Val Lys Val Lys Ala Leu Pro 
385                 390                 395                 400 


Leu Pro Asp Arg Leu Lys Trp Tyr Leu Leu Ser Glu His Ser Gly Ser 
                405                 410                 415     


Val Glu Asp Asp Ile 
            420     


<210> 3376
<211> 274
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<400> 3376
Met Leu His His His Cys Arg Arg Asn Pro Glu Leu Gln Glu Glu Leu 
1               5                   10                  15      


Gln Ile Gln Ala Ala Val Ala Ala Gly Asp Val His Xaa Val Arg Lys 
            20                  25                  30          


Met Leu Glu Gln Gly Tyr Ser Pro Asn Gly Arg Asp Ala Asn Gly Trp 
        35                  40                  45              


Xaa Leu Leu His Phe Ser Ala Ala Arg Gly Lys Glu Arg Cys Val Arg 
    50                  55                  60                  


Val Phe Leu Glu His Gly Ala Asp Pro Xaa Val Lys Asp Leu Ile Gly 
65                  70                  75                  80  


Gly Phe Xaa Ala Leu His Tyr Ala Ala Met His Gly Arg Ala Arg Ile 
                85                  90                  95      


Ala Arg Leu Met Leu Glu Ser Glu Tyr Arg Ser Asp Ile Ile Asn Ala 
            100                 105                 110         


Lys Ser Asn Asp Gly Trp Xaa Pro Leu His Val Ala Ala His Tyr Gly 
        115                 120                 125             


Arg Asp Ser Phe Val Arg Leu Leu Leu Glu Phe Lys Ala Glu Val Asp 
    130                 135                 140                 


Pro Leu Ser Asp Lys Gly Xaa Xaa Pro Leu Gln Leu Ala Ile Ile Arg 
145                 150                 155                 160 


Glu Arg Ser Ser Cys Val Lys Ile Leu Leu Asp His Asn Ala Asn Ile 
                165                 170                 175     


Asp Ile Gln Asn Gly Phe Leu Leu Arg Tyr Ala Val Ile Lys Ser Asn 
            180                 185                 190         


His Ser Tyr Cys Arg Met Phe Leu Gln Arg Gly Ala Asp Xaa Asn Leu 
        195                 200                 205             


Gly Arg Leu Glu Asp Gly Gln Xaa Pro Leu His Leu Ser Ala Leu Arg 
    210                 215                 220                 


Asp Asp Val Leu Cys Ala Arg Met Leu Tyr Asn Tyr Gly Ala Asp Xaa 
225                 230                 235                 240 


Asn Xaa Arg Asn Tyr Glu Gly Gln Xaa Pro Leu Ala Val Ser Ile Ser 
                245                 250                 255     


Ile Ser Gly Ser Ser Arg Pro Cys Leu Asp Phe Leu Gln Glu Val Xaa 
            260                 265                 270         


Ser Met 
        


<210> 3377
<211> 318
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<400> 3377
Met Leu His His His Cys Arg Arg Asn Pro Glu Leu Gln Glu Glu Leu 
1               5                   10                  15      


Gln Ile Gln Ala Ala Val Ala Ala Gly Asp Val His Xaa Val Arg Lys 
            20                  25                  30          


Met Leu Glu Gln Gly Tyr Ser Pro Asn Gly Arg Asp Ala Asn Gly Trp 
        35                  40                  45              


Xaa Leu Leu His Phe Ser Ala Ala Arg Gly Lys Glu Arg Cys Val Arg 
    50                  55                  60                  


Val Phe Leu Glu His Gly Ala Asp Pro Xaa Val Lys Asp Leu Ile Gly 
65                  70                  75                  80  


Gly Phe Xaa Ala Leu His Tyr Ala Ala Met His Gly Arg Ala Arg Ile 
                85                  90                  95      


Ala Arg Leu Met Leu Glu Ser Glu Tyr Arg Ser Asp Ile Ile Asn Ala 
            100                 105                 110         


Lys Ser Asn Asp Gly Trp Xaa Pro Leu His Val Ala Ala His Tyr Gly 
        115                 120                 125             


Arg Asp Ser Phe Val Arg Leu Leu Leu Glu Phe Lys Ala Glu Val Asp 
    130                 135                 140                 


Pro Leu Ser Asp Lys Gly Xaa Xaa Pro Leu Gln Leu Ala Ile Ile Arg 
145                 150                 155                 160 


Glu Arg Ser Ser Cys Val Lys Ile Leu Leu Asp His Asn Ala Asn Ile 
                165                 170                 175     


Asp Ile Gln Asn Gly Phe Leu Leu Arg Tyr Ala Val Ile Lys Ser Asn 
            180                 185                 190         


His Ser Tyr Cys Arg Met Phe Leu Gln Arg Gly Ala Asp Xaa Asn Leu 
        195                 200                 205             


Gly Arg Leu Glu Asp Gly Gln Xaa Pro Leu His Leu Ser Ala Leu Arg 
    210                 215                 220                 


Asp Asp Val Leu Cys Ala Arg Met Leu Tyr Asn Tyr Gly Ala Asp Xaa 
225                 230                 235                 240 


Asn Xaa Arg Asn Tyr Glu Gly Gln Xaa Pro Leu Ala Val Ser Ile Ser 
                245                 250                 255     


Ile Ser Gly Ser Ser Arg Pro Cys Leu Asp Phe Leu Gln Glu Val Xaa 
            260                 265                 270         


Arg Gln Pro Arg Asn Leu Gln Asp Leu Cys Arg Ile Lys Ile Arg Gln 
        275                 280                 285             


Cys Ile Gly Leu Gln Asn Leu Lys Leu Leu Asp Glu Leu Pro Ile Ala 
    290                 295                 300                 


Lys Val Met Lys Asp Tyr Leu Lys His Lys Phe Asp Asp Ile 
305                 310                 315             


<210> 3378
<211> 116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<400> 3378
Met Leu His His His Cys Arg Arg Asn Pro Glu Leu Gln Glu Glu Leu 
1               5                   10                  15      


Gln Ile Gln Ala Ala Val Ala Ala Gly Asp Val His Xaa Val Arg Lys 
            20                  25                  30          


Met Leu Glu Gln Gly Tyr Ser Pro Asn Gly Arg Asp Ala Asn Gly Trp 
        35                  40                  45              


Xaa Leu Leu His Phe Ser Ala Ala Arg Gly Lys Glu Arg Cys Val Arg 
    50                  55                  60                  


Val Phe Leu Glu His Gly Gly Gln Pro Arg Asn Leu Gln Asp Leu Cys 
65                  70                  75                  80  


Arg Ile Lys Ile Arg Gln Cys Ile Gly Leu Gln Asn Leu Lys Leu Leu 
                85                  90                  95      


Asp Glu Leu Pro Ile Ala Lys Val Met Lys Asp Tyr Leu Lys His Lys 
            100                 105                 110         


Phe Asp Asp Ile 
        115     


<210> 3379
<211> 51
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 3379
Met Ser Ser Ser Met Trp Tyr Ile Met Gln Ser Ile Gln Ser Lys Tyr 
1               5                   10                  15      


Ser Leu Ser Glu Arg Leu Ile Arg Xaa Ile Ala Ala Ile Arg Ser Phe 
            20                  25                  30          


Pro His Asp Asn Val Glu Asp Leu Ile Arg Gly Gly Ala Asp Val Asn 
        35                  40                  45              


Cys Xaa His 
    50      


<210> 3380
<211> 85
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 3380
Met Ser Ser Ser Met Trp Tyr Ile Met Gln Ser Ile Gln Ser Lys Tyr 
1               5                   10                  15      


Ser Leu Ser Glu Arg Leu Ile Arg Xaa Ile Ala Ala Ile Arg Ser Phe 
            20                  25                  30          


Pro His Asp Asn Val Glu Asp Leu Ile Arg Gly Gly Ala Asp Val Asn 
        35                  40                  45              


Cys Xaa His Gly Xaa Leu Lys Pro Leu His Cys Ala Cys Met Val Ser 
    50                  55                  60                  


Asp Ala Asp Cys Val Glu Leu Leu Leu Glu Lys Gly Ala Glu Asp Ser 
65                  70                  75                  80  


Leu Gly Val Ala Cys 
                85  


<210> 3381
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 3381
Met Ser Ser Ser Met Trp Tyr Ile Met Gln Ser Ile Gln Ser Lys Tyr 
1               5                   10                  15      


Ser Leu Ser Glu Arg Leu Ile Arg Xaa Ile Ala Ala Ile Arg Ser Phe 
            20                  25                  30          


Pro His Asp Asn Val Glu Asp Leu Ile Arg Gly Gly Ala Asp Val Asn 
        35                  40                  45              


Cys Xaa His Gly Xaa Leu Lys Pro Leu His Cys Ala Cys Met Val Ser 
    50                  55                  60                  


Asp Ala Asp Cys Val Glu Leu Leu Leu Glu Lys Gly Ala Glu Leu Leu 
65                  70                  75                  80  


Ser Tyr Leu His Leu Tyr His Gln Asp Ser Leu Gly Val Ala Cys 
                85                  90                  95  


<210> 3382
<211> 86
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<400> 3382
Met Ser Ser Ser Met Trp Tyr Ile Met Gln Ser Ile Gln Ser Lys Tyr 
1               5                   10                  15      


Ser Leu Ser Glu Arg Leu Ile Arg Xaa Ile Ala Ala Ile Arg Ser Phe 
            20                  25                  30          


Pro His Asp Asn Val Glu Asp Leu Ile Arg Gly Gly Ala Asp Val Asn 
        35                  40                  45              


Cys Xaa His Gly Xaa Leu Lys Pro Leu His Cys Ala Cys Met Val Ser 
    50                  55                  60                  


Asp Ala Asp Cys Val Glu Leu Leu Leu Glu Lys Gly Ala Glu Val Met 
65                  70                  75                  80  


Phe Leu Xaa His Ser His 
                85      


<210> 3383
<211> 112
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 3383
Met Ser Ser Ser Met Trp Tyr Ile Met Gln Ser Ile Gln Ser Lys Tyr 
1               5                   10                  15      


Ser Leu Ser Glu Arg Leu Ile Arg Xaa Ile Ala Ala Ile Arg Ser Phe 
            20                  25                  30          


Pro His Asp Asn Val Glu Asp Leu Ile Arg Gly Gly Ala Asp Val Asn 
        35                  40                  45              


Cys Xaa His Gly Xaa Leu Lys Pro Leu His Cys Ala Cys Met Val Ser 
    50                  55                  60                  


Asp Ala Asp Cys Val Glu Leu Leu Leu Glu Lys Gly Ala Glu Val Asn 
65                  70                  75                  80  


Ala Leu Asp Gly Tyr Asn Arg Xaa Ala Leu His Tyr Ala Ala Glu Lys 
                85                  90                  95      


Asp Glu Ala Cys Val Glu Val Leu Leu Glu Tyr Gly Ala Asn Pro Asn 
            100                 105                 110         


<210> 3384
<211> 114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 3384
Met Ser Ser Ser Met Trp Tyr Ile Met Gln Ser Ile Gln Ser Lys Tyr 
1               5                   10                  15      


Ser Leu Ser Glu Arg Leu Ile Arg Xaa Ile Ala Ala Ile Arg Ser Phe 
            20                  25                  30          


Pro His Asp Asn Val Glu Asp Leu Ile Arg Gly Gly Ala Asp Val Asn 
        35                  40                  45              


Cys Xaa His Gly Xaa Leu Lys Pro Leu His Cys Ala Cys Met Val Ser 
    50                  55                  60                  


Asp Ala Asp Cys Val Glu Leu Leu Leu Glu Lys Gly Ala Glu Val Asn 
65                  70                  75                  80  


Ala Leu Asp Gly Tyr Asn Arg Xaa Ala Leu His Tyr Ala Ala Glu Lys 
                85                  90                  95      


Asp Glu Ala Cys Val Glu Val Leu Leu Glu Tyr Gly Ala Asn Pro Asn 
            100                 105                 110         


Ala Leu 
        


<210> 3385
<211> 127
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<400> 3385
Met Ser Ser Ser Met Trp Tyr Ile Met Gln Ser Ile Gln Ser Lys Tyr 
1               5                   10                  15      


Ser Leu Ser Glu Arg Leu Ile Arg Xaa Ile Ala Ala Ile Arg Ser Phe 
            20                  25                  30          


Pro His Asp Asn Val Glu Asp Leu Ile Arg Gly Gly Ala Asp Val Asn 
        35                  40                  45              


Cys Xaa His Gly Xaa Leu Lys Pro Leu His Cys Ala Cys Met Val Ser 
    50                  55                  60                  


Asp Ala Asp Cys Val Glu Leu Leu Leu Glu Lys Gly Ala Glu Val Asn 
65                  70                  75                  80  


Ala Leu Asp Gly Tyr Asn Arg Xaa Ala Leu His Tyr Ala Ala Glu Lys 
                85                  90                  95      


Asp Glu Ala Cys Val Glu Val Leu Leu Glu Tyr Gly Ala Asn Pro Asn 
            100                 105                 110         


Ala Leu Asp Gly Asn Arg Asp Xaa Pro Leu His Trp Ala Ala Phe 
        115                 120                 125         


<210> 3386
<211> 288
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<400> 3386
Met Ser Ser Ser Met Trp Tyr Ile Met Gln Ser Ile Gln Ser Lys Tyr 
1               5                   10                  15      


Ser Leu Ser Glu Arg Leu Ile Arg Xaa Ile Ala Ala Ile Arg Ser Phe 
            20                  25                  30          


Pro His Asp Asn Val Glu Asp Leu Ile Arg Gly Gly Ala Asp Val Asn 
        35                  40                  45              


Cys Xaa His Gly Xaa Leu Lys Pro Leu His Cys Ala Cys Met Val Ser 
    50                  55                  60                  


Asp Ala Asp Cys Val Glu Leu Leu Leu Glu Lys Gly Ala Glu Val Asn 
65                  70                  75                  80  


Ala Leu Asp Gly Tyr Asn Arg Xaa Ala Leu His Tyr Ala Ala Glu Lys 
                85                  90                  95      


Asp Glu Ala Cys Val Glu Val Leu Leu Glu Tyr Gly Ala Asn Pro Asn 
            100                 105                 110         


Ala Leu Asp Gly Asn Arg Asp Xaa Pro Leu His Trp Ala Ala Phe Lys 
        115                 120                 125             


Asn Asn Ala Glu Cys Val Arg Ala Leu Leu Glu Ser Gly Ala Ser Val 
    130                 135                 140                 


Asn Ala Leu Asp Tyr Asn Asn Asp Xaa Pro Leu Ser Trp Ala Ala Met 
145                 150                 155                 160 


Lys Gly Asn Leu Glu Ser Val Ser Ile Leu Leu Asp Tyr Gly Ala Glu 
                165                 170                 175     


Val Arg Val Ile Asn Leu Ile Gly Gln Xaa Pro Ile Ser Arg Leu Val 
            180                 185                 190         


Ala Leu Leu Val Arg Gly Leu Gly Xaa Glu Lys Glu Asp Ser Cys Phe 
        195                 200                 205             


Glu Leu Leu His Arg Ala Val Gly His Phe Glu Leu Arg Lys Asn Gly 
    210                 215                 220                 


Xaa Met Pro Arg Glu Val Ala Arg Asp Pro Gln Leu Cys Glu Lys Leu 
225                 230                 235                 240 


Xaa Val Leu Cys Ser Ala Pro Gly Xaa Leu Lys Xaa Leu Ala Arg Tyr 
                245                 250                 255     


Ala Val Arg Arg Ser Leu Gly Leu Gln Tyr Leu Pro Asp Ala Val Lys 
            260                 265                 270         


Gly Leu Pro Leu Pro Ala Ser Leu Lys Glu Tyr Leu Leu Leu Leu Glu 
        275                 280                 285             


<210> 3387
<211> 65
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<400> 3387
Met Ser Ser Ser Met Trp Tyr Ile Met Gln Ser Ile Gln Ser Lys Tyr 
1               5                   10                  15      


Ser Leu Ser Glu Arg Leu Ile Arg Xaa Ile Ala Ala Ile Arg Ser Phe 
            20                  25                  30          


Pro His Asp Asn Val Glu Asp Leu Ile Arg Gly Ser Met Val Ala Ile 
        35                  40                  45              


Glu Ser Gly Leu Leu Val Gln Leu Ser Cys Leu Met Ile Arg Glu Gln 
    50                  55                  60                  


Met 
65  


<210> 3388
<211> 66
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<400> 3388
Met Ser Ser Ser Met Trp Tyr Ile Met Gln Ser Ile Gln Ser Lys Tyr 
1               5                   10                  15      


Ser Leu Ser Glu Arg Leu Ile Arg Xaa Ile Ala Ala Ile Arg Ser Phe 
            20                  25                  30          


Pro His Asp Asn Val Glu Asp Leu Ile Arg Gly Ser Met Val Ala Ile 
        35                  40                  45              


Glu Ser Gly Leu Leu Val Gln Leu Ser Cys Leu Met Ile Arg Phe Pro 
    50                  55                  60                  


Val Leu 
65      


<210> 3389
<211> 252
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<400> 3389
Met Asp Gly Lys Gln Gly Gly Met Asp Gly Ser Lys Pro Ala Gly Pro 
1               5                   10                  15      


Arg Asp Phe Pro Gly Ile Arg Leu Leu Ser Asn Pro Leu Met Gly Asp 
            20                  25                  30          


Ala Val Ser Asp Trp Ser Pro Met His Glu Ala Ala Ile His Gly His 
        35                  40                  45              


Gln Leu Ser Leu Arg Asn Leu Ile Ser Gln Gly Trp Ala Val Asn Ile 
    50                  55                  60                  


Ile Xaa Ala Asp His Val Ser Pro Leu His Glu Ala Cys Leu Gly Gly 
65                  70                  75                  80  


His Leu Ser Cys Val Lys Ile Leu Leu Lys His Gly Ala Gln Val Asn 
                85                  90                  95      


Gly Val Xaa Ala Asp Trp His Xaa Pro Leu Phe Asn Ala Cys Val Ser 
            100                 105                 110         


Gly Ser Trp Asp Cys Val Asn Leu Leu Leu Gln His Gly Ala Ser Val 
        115                 120                 125             


Gln Pro Glu Ser Asp Leu Ala Ser Pro Ile His Glu Ala Ala Arg Arg 
    130                 135                 140                 


Ala Tyr Gly Gly Asn Ile Asp His Lys Ile Ser His Leu Gly Xaa Pro 
145                 150                 155                 160 


Leu Tyr Leu Ala Cys Glu Asn Gln Gln Arg Ala Cys Val Lys Lys Leu 
                165                 170                 175     


Leu Glu Ser Gly Ala Asp Val Asn Gln Gly Lys Gly Gln Asp Ser Pro 
            180                 185                 190         


Leu His Ala Val Ala Arg Xaa Ala Ser Glu Glu Leu Ala Cys Leu Leu 
        195                 200                 205             


Met Asp Phe Gly Ala Asp Xaa Gln Ala Lys Asn Ala Glu Gly Lys Arg 
    210                 215                 220                 


Pro Val Glu Leu Val Pro Pro Glu Ser Pro Leu Ala Gln Leu Phe Leu 
225                 230                 235                 240 


Glu Arg Glu Gly Ala Ser Leu Pro Lys Pro Lys Pro 
                245                 250         


<210> 3390
<211> 262
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<400> 3390
Met Asp Gly Lys Gln Gly Gly Met Asp Gly Ser Lys Pro Ala Gly Pro 
1               5                   10                  15      


Arg Asp Phe Pro Gly Ile Arg Leu Leu Ser Asn Pro Leu Met Gly Asp 
            20                  25                  30          


Ala Val Ser Asp Trp Ser Pro Met His Glu Ala Ala Ile His Gly His 
        35                  40                  45              


Gln Leu Ser Leu Arg Asn Leu Ile Ser Gln Gly Trp Ala Val Asn Ile 
    50                  55                  60                  


Ile Xaa Ala Asp His Val Ser Pro Leu His Glu Ala Cys Leu Gly Gly 
65                  70                  75                  80  


His Leu Ser Cys Val Lys Ile Leu Leu Lys His Gly Ala Gln Val Asn 
                85                  90                  95      


Gly Val Xaa Ala Asp Trp His Xaa Pro Leu Phe Asn Ala Cys Val Ser 
            100                 105                 110         


Gly Ser Trp Asp Cys Val Asn Leu Leu Leu Gln His Gly Ala Ser Val 
        115                 120                 125             


Gln Pro Glu Ser Asp Leu Ala Ser Pro Ile His Glu Ala Ala Arg Arg 
    130                 135                 140                 


Gly His Val Glu Cys Val Asn Ser Leu Ile Ala Tyr Gly Gly Asn Ile 
145                 150                 155                 160 


Asp His Lys Ile Ser His Leu Gly Xaa Pro Leu Tyr Leu Ala Cys Glu 
                165                 170                 175     


Asn Gln Gln Arg Ala Cys Val Lys Lys Leu Leu Glu Ser Gly Ala Asp 
            180                 185                 190         


Val Asn Gln Gly Lys Gly Gln Asp Ser Pro Leu His Ala Val Ala Arg 
        195                 200                 205             


Xaa Ala Ser Glu Glu Leu Ala Cys Leu Leu Met Asp Phe Gly Ala Asp 
    210                 215                 220                 


Xaa Gln Ala Lys Asn Ala Glu Gly Lys Arg Pro Val Glu Leu Val Pro 
225                 230                 235                 240 


Pro Glu Ser Pro Leu Ala Gln Leu Phe Leu Glu Arg Glu Gly Ala Ser 
                245                 250                 255     


Leu Pro Lys Pro Lys Pro 
            260         


<210> 3391
<211> 294
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<400> 3391
Met Asp Gly Lys Gln Gly Gly Met Asp Gly Ser Lys Pro Ala Gly Pro 
1               5                   10                  15      


Arg Asp Phe Pro Gly Ile Arg Leu Leu Ser Asn Pro Leu Met Gly Asp 
            20                  25                  30          


Ala Val Ser Asp Trp Ser Pro Met His Glu Ala Ala Ile His Gly His 
        35                  40                  45              


Gln Leu Ser Leu Arg Asn Leu Ile Ser Gln Gly Trp Ala Val Asn Ile 
    50                  55                  60                  


Ile Xaa Ala Asp His Val Ser Pro Leu His Glu Ala Cys Leu Gly Gly 
65                  70                  75                  80  


His Leu Ser Cys Val Lys Ile Leu Leu Lys His Gly Ala Gln Val Asn 
                85                  90                  95      


Gly Val Xaa Ala Asp Trp His Xaa Pro Leu Phe Asn Ala Cys Val Ser 
            100                 105                 110         


Gly Ser Trp Asp Cys Val Asn Leu Leu Leu Gln His Gly Ala Ser Val 
        115                 120                 125             


Gln Pro Glu Ser Asp Leu Ala Ser Pro Ile His Glu Ala Ala Arg Arg 
    130                 135                 140                 


Gly His Val Glu Cys Val Asn Ser Leu Ile Ala Tyr Gly Gly Asn Ile 
145                 150                 155                 160 


Asp His Lys Ile Ser His Leu Gly Xaa Pro Leu Tyr Leu Ala Cys Glu 
                165                 170                 175     


Asn Gln Gln Arg Ala Cys Val Lys Lys Leu Leu Glu Ser Gly Ala Asp 
            180                 185                 190         


Val Asn Gln Gly Lys Gly Gln Asp Ser Pro Leu His Ala Val Ala Arg 
        195                 200                 205             


Xaa Ala Ser Glu Glu Leu Ala Cys Leu Leu Met Asp Phe Gly Ala Asp 
    210                 215                 220                 


Xaa Gln Ala Lys Asn Ala Glu Gly Lys Arg Pro Val Glu Leu Val Pro 
225                 230                 235                 240 


Pro Glu Ser Pro Leu Ala Gln Leu Phe Leu Glu Arg Glu Gly Pro Pro 
                245                 250                 255     


Ser Leu Met Gln Leu Cys Arg Leu Arg Ile Arg Lys Cys Phe Gly Ile 
            260                 265                 270         


Gln Gln His His Lys Ile Xaa Lys Leu Val Leu Pro Glu Asp Leu Lys 
        275                 280                 285             


Gln Phe Leu Leu His Leu 
    290                 


<210> 3392
<211> 211
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<400> 3392
Xaa Lys Ile Leu Leu Lys His Gly Ala Gln Val Asn Gly Val Xaa Ala 
1               5                   10                  15      


Asp Trp His Xaa Pro Leu Phe Asn Ala Cys Val Ser Gly Ser Trp Asp 
            20                  25                  30          


Cys Val Asn Leu Leu Leu Gln His Gly Ala Ser Val Gln Pro Glu Ser 
        35                  40                  45              


Asp Leu Ala Ser Pro Ile His Glu Ala Ala Arg Arg Gly His Val Glu 
    50                  55                  60                  


Cys Val Asn Ser Leu Ile Ala Tyr Gly Gly Asn Ile Asp His Lys Ile 
65                  70                  75                  80  


Ser His Leu Gly Xaa Pro Leu Tyr Leu Ala Cys Glu Asn Gln Gln Arg 
                85                  90                  95      


Ala Cys Val Lys Lys Leu Leu Glu Ser Gly Ala Asp Val Asn Gln Gly 
            100                 105                 110         


Lys Gly Gln Asp Ser Pro Leu His Ala Val Ala Arg Xaa Ala Ser Glu 
        115                 120                 125             


Glu Leu Ala Cys Leu Leu Met Asp Phe Gly Ala Asp Xaa Gln Ala Lys 
    130                 135                 140                 


Asn Ala Glu Gly Lys Arg Pro Val Glu Leu Val Pro Pro Glu Ser Pro 
145                 150                 155                 160 


Leu Ala Gln Leu Phe Leu Glu Arg Glu Asp Gly Val Xaa Leu Cys Arg 
                165                 170                 175     


Pro Gly Trp Ser Ala Val Ala Arg Ser Arg Leu Ile Ala Xaa Ser Ala 
            180                 185                 190         


Ser Arg Asn Ser Asp Lys Met Cys Ser Pro Gly Gln Gln Ser Phe Met 
        195                 200                 205             


Leu Leu Val 
    210     


<210> 3393
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 3393
Met Pro Ala Leu Pro Leu Asp Gln Leu Gln Ile Xaa His Lys Asp Pro 
1               5                   10                  15      


Lys Xaa Gly Lys Leu Arg Xaa Ser Pro Ala Leu Glu Xaa Ser Leu His 
            20                  25                  30          


Ser Ser Gln Val Xaa Xaa Val Xaa Trp Met Lys Pro Cys Leu Pro Ser 
        35                  40                  45              


Phe Arg Ser Ser Ala Ile Ser Ser Ser Xaa Val Val Cys Lys Gly Xaa 
    50                  55                  60                  


Gly Pro Ile Pro His Pro Arg Ser Leu Arg Arg Gly Ala Asp 
65                  70                  75              


<210> 3394
<211> 240
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<400> 3394
Met Pro Ala Leu Pro Leu Asp Gln Leu Gln Ile Xaa His Lys Asp Pro 
1               5                   10                  15      


Lys Xaa Gly Lys Leu Arg Xaa Ser Pro Ala Leu His Pro Glu Gln Lys 
            20                  25                  30          


Ala Asp Arg Tyr Phe Val Leu Tyr Lys Pro Pro Pro Lys Asp Asn Ile 
        35                  40                  45              


Pro Ala Leu Val Glu Glu Tyr Leu Glu Arg Ala Xaa Phe Val Ala Asn 
    50                  55                  60                  


Asp Leu Asp Trp Leu Leu Ala Leu Pro His Asp Lys Phe Trp Cys Gln 
65                  70                  75                  80  


Val Ile Phe Asp Glu Xaa Leu Gln Lys Cys Leu Asp Ser Tyr Leu Arg 
                85                  90                  95      


Tyr Val Pro Arg Lys Phe Asp Glu Gly Val Ala Ser Ala Pro Glu Val 
            100                 105                 110         


Val Asp Met Gln Lys Arg Leu His Arg Ser Val Phe Leu Xaa Phe Leu 
        115                 120                 125             


Arg Met Ser Xaa His Lys Glu Ser Lys Asp His Phe Ile Ser Pro Ser 
    130                 135                 140                 


Ala Phe Gly Glu Ile Leu Tyr Asn Asn Phe Leu Phe Asp Ile Pro Lys 
145                 150                 155                 160 


Ile Leu Asp Leu Cys Val Leu Phe Gly Lys Gly Asn Ser Pro Leu Leu 
                165                 170                 175     


Gln Lys Met Ile Gly Asn Ile Phe Xaa Gln Gln Pro Ser Tyr Tyr Ser 
            180                 185                 190         


Asp Leu Asp Glu Xaa Leu Pro Xaa Ile Leu Gln Val Phe Ser Asn Ile 
        195                 200                 205             


Leu Gln His Cys Gly Leu Gln Gly Asp Gly Ala Asn Xaa Xaa Pro Gln 
    210                 215                 220                 


Lys Leu Glu Glu Arg Gly Arg Leu Xaa Pro Ser Asp Met Pro Leu Leu 
225                 230                 235                 240 


<210> 3395
<211> 757
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<400> 3395
Met Pro Ala Leu Pro Leu Asp Gln Leu Gln Ile Xaa His Lys Asp Pro 
1               5                   10                  15      


Lys Xaa Gly Lys Leu Arg Xaa Ser Pro Ala Leu His Pro Glu Gln Lys 
            20                  25                  30          


Ala Asp Arg Tyr Phe Val Leu Tyr Lys Pro Pro Pro Lys Asp Asn Ile 
        35                  40                  45              


Pro Ala Leu Val Glu Glu Tyr Leu Glu Arg Ala Xaa Phe Val Ala Asn 
    50                  55                  60                  


Asp Leu Asp Trp Leu Leu Ala Leu Pro His Asp Lys Phe Trp Cys Gln 
65                  70                  75                  80  


Val Ile Phe Asp Glu Xaa Leu Gln Lys Cys Leu Asp Ser Tyr Leu Arg 
                85                  90                  95      


Tyr Val Pro Arg Lys Phe Asp Glu Gly Val Ala Ser Ala Pro Glu Val 
            100                 105                 110         


Val Asp Met Gln Lys Arg Leu His Arg Ser Val Phe Leu Xaa Phe Leu 
        115                 120                 125             


Arg Met Ser Xaa His Lys Glu Ser Lys Asp His Phe Ile Ser Pro Ser 
    130                 135                 140                 


Ala Phe Gly Glu Ile Leu Tyr Asn Asn Phe Leu Phe Asp Ile Pro Lys 
145                 150                 155                 160 


Ile Leu Asp Leu Cys Val Leu Phe Gly Lys Gly Asn Ser Pro Leu Leu 
                165                 170                 175     


Gln Lys Met Ile Gly Asn Ile Phe Xaa Gln Gln Pro Ser Tyr Tyr Ser 
            180                 185                 190         


Asp Leu Asp Glu Xaa Leu Pro Xaa Ile Leu Gln Val Phe Ser Asn Ile 
        195                 200                 205             


Leu Gln His Cys Gly Leu Gln Gly Asp Gly Ala Asn Xaa Xaa Pro Gln 
    210                 215                 220                 


Lys Leu Glu Glu Arg Gly Arg Leu Xaa Pro Ser Asp Met Pro Leu Leu 
225                 230                 235                 240 


Glu Leu Lys Asp Ile Val Leu Tyr Leu Cys Asp Xaa Cys Xaa Xaa Leu 
                245                 250                 255     


Trp Ala Phe Leu Asp Ile Phe Pro Leu Ala Cys Gln Xaa Phe Gln Lys 
            260                 265                 270         


His Asp Phe Cys Tyr Arg Leu Ala Ser Phe Tyr Glu Ala Ala Ile Pro 
        275                 280                 285             


Glu Met Glu Ser Ala Ile Lys Lys Arg Arg Leu Glu Asp Ser Lys Leu 
    290                 295                 300                 


Leu Gly Asp Leu Trp Gln Arg Leu Ser His Ser Arg Lys Lys Leu Met 
305                 310                 315                 320 


Glu Ile Phe His Ile Ile Leu Asn Gln Ile Cys Leu Leu Pro Ile Leu 
                325                 330                 335     


Glu Ser Ser Cys Asp Asn Ile Gln Gly Phe Ile Glu Glu Phe Leu Gln 
            340                 345                 350         


Ile Phe Ser Ser Leu Leu Gln Glu Lys Arg Phe Leu Arg Asp Tyr Asp 
        355                 360                 365             


Ala Leu Phe Pro Val Ala Glu Asp Ile Ser Leu Leu Gln Gln Ala Ser 
    370                 375                 380                 


Ser Val Leu Asp Glu Xaa Arg Xaa Ala Tyr Ile Leu Gln Ala Val Glu 
385                 390                 395                 400 


Ser Ala Trp Glu Gly Val Asp Arg Arg Lys Ala Xaa Asp Ala Lys Asp 
                405                 410                 415     


Pro Ser Val Ile Glu Glu Pro Asn Gly Glu Pro Asn Gly Val Xaa Val 
            420                 425                 430         


Xaa Ala Glu Ala Val Ser Gln Ala Ser Ser His Pro Glu Asn Ser Glu 
        435                 440                 445             


Glu Glu Glu Cys Met Gly Ala Ala Ala Ala Val Gly Pro Ala Met Cys 
    450                 455                 460                 


Gly Val Glu Leu Asp Ser Leu Ile Ser Gln Val Lys Asp Leu Leu Pro 
465                 470                 475                 480 


Asp Leu Gly Glu Gly Phe Ile Leu Ala Cys Leu Glu Tyr Tyr His Tyr 
                485                 490                 495     


Asp Pro Glu Gln Val Ile Asn Asn Ile Leu Glu Glu Arg Leu Ala Pro 
            500                 505                 510         


Xaa Leu Ser Gln Leu Asp Arg Asn Leu Asp Arg Glu Met Lys Pro Asp 
        515                 520                 525             


Pro Xaa Pro Leu Leu Xaa Ser Arg His Asn Val Phe Gln Asn Asp Glu 
    530                 535                 540                 


Phe Asp Val Phe Ser Arg Asp Ser Val Asp Leu Ser Arg Val His Lys 
545                 550                 555                 560 


Gly Lys Ser Xaa Arg Lys Glu Glu Asn Xaa Arg Ser Leu Leu Asn Asp 
                565                 570                 575     


Lys Arg Ala Val Ala Ala Gln Arg Gln Arg Tyr Glu Gln Tyr Ser Val 
            580                 585                 590         


Val Val Glu Glu Val Pro Leu Gln Pro Gly Glu Ser Leu Pro Tyr His 
        595                 600                 605             


Ser Val Tyr Tyr Glu Asp Glu Tyr Asp Asp Xaa Tyr Asp Gly Asn Gln 
    610                 615                 620                 


Val Gly Ala Asn Asp Ala Asp Ser Asp Asp Glu Leu Ile Ser Arg Arg 
625                 630                 635                 640 


Pro Phe Xaa Ile Pro Gln Val Leu Arg Xaa Lys Val Pro Arg Glu Gly 
                645                 650                 655     


Gln Glu Glu Asp Asp Asp Asp Glu Glu Asp Asp Ala Asp Glu Glu Ala 
            660                 665                 670         


Pro Lys Pro Asp His Phe Val Gln Asp Pro Ala Val Leu Arg Glu Lys 
        675                 680                 685             


Ala Glu Ala Arg Arg Met Ala Phe Leu Ala Lys Lys Gly Tyr Arg His 
    690                 695                 700                 


Asp Ser Ser Xaa Ala Val Ala Gly Ser Pro Arg Gly His Gly Gln Ser 
705                 710                 715                 720 


Arg Glu Xaa Xaa Gln Glu Arg Arg Lys Lys Glu Ala Asn Lys Ala Xaa 
                725                 730                 735     


Arg Ala Asn His Asn Arg Arg Xaa Met Ala Asp Arg Lys Arg Ser Lys 
            740                 745                 750         


Gly Met Ile Pro Ser 
        755         


<210> 3396
<211> 37
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<400> 3396
Met Pro Ala Leu Pro Leu Asp Gln Leu Gln Ile Xaa His Lys Asp Pro 
1               5                   10                  15      


Lys Xaa Gly Lys Leu Arg Xaa Ser Pro Ala Leu Ile Cys Xaa Cys Asn 
            20                  25                  30          


Ser Met Ile Gln Ile 
        35          


<210> 3397
<211> 681
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<400> 3397
Met Pro Ala Leu Pro Leu Asp Gln Leu Gln Ile Xaa His Lys Asp Pro 
1               5                   10                  15      


Lys Xaa Gly Lys Leu Arg Xaa Ser Pro Ala Leu Val Ile Phe Asp Glu 
            20                  25                  30          


Xaa Leu Gln Lys Cys Leu Asp Ser Tyr Leu Arg Tyr Val Pro Arg Lys 
        35                  40                  45              


Phe Asp Glu Gly Val Ala Ser Ala Pro Glu Val Val Asp Met Gln Lys 
    50                  55                  60                  


Arg Leu His Arg Ser Val Phe Leu Xaa Phe Leu Arg Met Ser Xaa His 
65                  70                  75                  80  


Lys Glu Ser Lys Ile Leu Asp Leu Cys Val Leu Phe Gly Lys Gly Asn 
                85                  90                  95      


Ser Pro Leu Leu Gln Lys Met Ile Gly Asn Ile Phe Xaa Gln Gln Pro 
            100                 105                 110         


Ser Tyr Tyr Ser Asp Leu Asp Glu Xaa Leu Pro Xaa Ile Leu Gln Val 
        115                 120                 125             


Phe Ser Asn Ile Leu Gln His Cys Gly Leu Gln Gly Asp Gly Ala Asn 
    130                 135                 140                 


Xaa Xaa Pro Gln Lys Leu Glu Glu Arg Gly Arg Leu Xaa Pro Ser Asp 
145                 150                 155                 160 


Met Pro Leu Leu Glu Leu Lys Asp Ile Val Leu Tyr Leu Cys Asp Xaa 
                165                 170                 175     


Cys Xaa Xaa Leu Trp Ala Phe Leu Asp Ile Phe Pro Leu Ala Cys Gln 
            180                 185                 190         


Xaa Phe Gln Lys His Asp Phe Cys Tyr Arg Leu Ala Ser Phe Tyr Glu 
        195                 200                 205             


Ala Ala Ile Pro Glu Met Glu Ser Ala Ile Lys Lys Arg Arg Leu Glu 
    210                 215                 220                 


Asp Ser Lys Leu Leu Gly Asp Leu Trp Gln Arg Leu Ser His Ser Arg 
225                 230                 235                 240 


Lys Lys Leu Met Glu Ile Phe His Ile Ile Leu Asn Gln Ile Cys Leu 
                245                 250                 255     


Leu Pro Ile Leu Glu Ser Ser Cys Asp Asn Ile Gln Gly Phe Ile Glu 
            260                 265                 270         


Glu Phe Leu Gln Ile Phe Ser Ser Leu Leu Gln Glu Lys Arg Phe Leu 
        275                 280                 285             


Arg Asp Tyr Asp Ala Leu Phe Pro Val Ala Glu Asp Ile Ser Leu Leu 
    290                 295                 300                 


Gln Gln Ala Ser Ser Val Leu Asp Glu Xaa Arg Xaa Ala Tyr Ile Leu 
305                 310                 315                 320 


Gln Ala Val Glu Ser Ala Trp Glu Gly Val Asp Arg Arg Lys Ala Xaa 
                325                 330                 335     


Asp Ala Lys Asp Pro Ser Val Ile Glu Glu Pro Asn Gly Glu Pro Asn 
            340                 345                 350         


Gly Val Xaa Val Xaa Ala Glu Ala Val Ser Gln Ala Ser Ser His Pro 
        355                 360                 365             


Glu Asn Ser Glu Glu Glu Glu Cys Met Gly Ala Ala Ala Ala Val Gly 
    370                 375                 380                 


Pro Ala Met Cys Gly Val Glu Leu Asp Ser Leu Ile Ser Gln Val Lys 
385                 390                 395                 400 


Asp Leu Leu Pro Asp Leu Gly Glu Gly Phe Ile Leu Ala Cys Leu Glu 
                405                 410                 415     


Tyr Tyr His Tyr Asp Pro Glu Gln Val Ile Asn Asn Ile Leu Glu Glu 
            420                 425                 430         


Arg Leu Ala Pro Xaa Leu Ser Gln Leu Asp Arg Asn Leu Asp Arg Glu 
        435                 440                 445             


Met Lys Pro Asp Pro Xaa Pro Leu Leu Xaa Ser Arg His Asn Val Phe 
    450                 455                 460                 


Gln Asn Asp Glu Phe Asp Val Phe Ser Arg Asp Ser Val Asp Leu Ser 
465                 470                 475                 480 


Arg Val His Lys Gly Lys Ser Xaa Arg Lys Glu Glu Asn Xaa Arg Ser 
                485                 490                 495     


Leu Leu Asn Asp Lys Arg Ala Val Ala Ala Gln Arg Gln Arg Tyr Glu 
            500                 505                 510         


Gln Tyr Ser Val Val Val Glu Glu Val Pro Leu Gln Pro Gly Glu Ser 
        515                 520                 525             


Leu Pro Tyr His Ser Val Tyr Tyr Glu Asp Glu Tyr Asp Asp Xaa Tyr 
    530                 535                 540                 


Asp Gly Asn Gln Val Gly Ala Asn Asp Ala Asp Ser Asp Asp Glu Leu 
545                 550                 555                 560 


Ile Ser Arg Arg Pro Phe Xaa Ile Pro Gln Val Leu Arg Xaa Lys Val 
                565                 570                 575     


Pro Arg Glu Gly Gln Glu Glu Asp Asp Asp Asp Glu Glu Asp Asp Ala 
            580                 585                 590         


Asp Glu Glu Ala Pro Lys Pro Asp His Phe Val Gln Asp Pro Ala Val 
        595                 600                 605             


Leu Arg Glu Lys Ala Glu Ala Arg Arg Met Ala Phe Leu Ala Lys Lys 
    610                 615                 620                 


Gly Tyr Arg His Asp Ser Ser Xaa Ala Val Ala Gly Ser Pro Arg Gly 
625                 630                 635                 640 


His Gly Gln Ser Arg Glu Xaa Xaa Gln Glu Arg Arg Lys Lys Glu Ala 
                645                 650                 655     


Asn Lys Ala Xaa Arg Ala Asn His Asn Arg Arg Xaa Met Ala Asp Arg 
            660                 665                 670         


Lys Arg Ser Lys Gly Met Ile Pro Ser 
        675                 680     


<210> 3398
<211> 87
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<400> 3398
Ser Trp Pro Ala Trp Ser Xaa Xaa Xaa Xaa Xaa Gln Ser Arg Glu Met 
1               5                   10                  15      


Lys Pro Asp Pro Xaa Pro Leu Leu Xaa Ser Arg His Asn Val Phe Gln 
            20                  25                  30          


Asn Asp Glu Phe Asp Val Phe Ser Arg Asp Ser Val Asp Leu Ser Arg 
        35                  40                  45              


Val His Lys Gly Lys Ser Xaa Arg Lys Glu Glu Asn Xaa Arg Ser Leu 
    50                  55                  60                  


Leu Asn Asp Lys Arg Ala Val Ala Ala Gln Arg Gln Arg Tyr Glu Gln 
65                  70                  75                  80  


Tyr Ser Val Val Val Glu Glu 
                85          


<210> 3399
<211> 54
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<400> 3399
Xaa Ser Ala Gly Ala Gln Gly Ala Val Xaa Val Val Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Xaa Glu Pro Val Val Glu Pro Pro Arg Pro Pro Arg 
            20                  25                  30          


Val Cys Arg Asp His Val Cys Leu Ile Cys Trp Asp Pro Arg Ala Gly 
        35                  40                  45              


Xaa Gly Gln Val Ile Leu 
    50                  


<210> 3400
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<400> 3400
Met Ala Leu Pro Arg Leu Xaa Gly Ala Leu Arg Ser Phe Ser Asn Val 
1               5                   10                  15      


Xaa Lys Gln Asp Asn Tyr Asn Glu Glu Val Ala Asp Leu Lys Ile Lys 
            20                  25                  30          


Arg Ser Lys Leu His Glu Gln Val Leu Asp Leu Gly Leu Xaa Trp Lys 
        35                  40                  45              


Lys Ile Ile Lys Phe Leu Asn Glu Lys Leu Glu Lys Ser Lys Met Gln 
    50                  55                  60                  


Ser Ile Asn Glu Asp Leu Lys Asp Ile Leu His Ala Ala Lys Gln Ile 
65                  70                  75                  80  


Glu Val Asn Cys Pro Phe Gln Lys Arg Arg Leu Asp Gly Lys Glu Glu 
                85                  90                  95      


Asp Glu Lys Met Ser Arg Ala Ser Asp Arg Phe Arg Gly Leu Arg 
            100                 105                 110     


<210> 3401
<211> 176
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<400> 3401
Met Ala Leu Pro Arg Leu Xaa Gly Ala Leu Arg Ser Phe Ser Asn Val 
1               5                   10                  15      


Xaa Lys Gln Asp Asn Tyr Asn Glu Glu Val Ala Asp Leu Lys Ile Lys 
            20                  25                  30          


Arg Ser Lys Leu His Glu Gln Val Leu Asp Leu Gly Leu Xaa Trp Lys 
        35                  40                  45              


Lys Ile Ile Lys Phe Leu Asn Glu Lys Leu Glu Lys Ser Lys Met Gln 
    50                  55                  60                  


Ser Ile Asn Glu Asp Leu Lys Asp Ile Leu His Ala Ala Lys Gln Ile 
65                  70                  75                  80  


Val Gly Xaa Asp Asn Gly Arg Glu Ala Ile Glu Ser Gly Ala Ala Phe 
                85                  90                  95      


Leu Phe Met Xaa Phe His Leu Lys Asp Ser Val Gly His Lys Glu Xaa 
            100                 105                 110         


Lys Ala Ile Lys Gln Met Phe Gly Pro Phe Pro Ser Ser Ser Ala Xaa 
        115                 120                 125             


Ala Ala Cys Asn Ala Xaa Asn Arg Ile Ile Ser His Phe Ser Gln Asp 
    130                 135                 140                 


Asp Leu Xaa Ala Leu Val Gln Met Xaa Glu Lys Glu His Gly Asp Arg 
145                 150                 155                 160 


Val Phe Phe Gly Lys Asn Leu Ala Phe Ser Phe Asp Met His Asp Leu 
                165                 170                 175     


<210> 3402
<211> 731
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<400> 3402
Met Ala Leu Pro Arg Leu Xaa Gly Ala Leu Arg Ser Phe Ser Asn Val 
1               5                   10                  15      


Xaa Lys Gln Asp Asn Tyr Asn Glu Glu Val Ala Asp Leu Lys Ile Lys 
            20                  25                  30          


Arg Ser Lys Leu His Glu Gln Val Leu Asp Leu Gly Leu Xaa Trp Lys 
        35                  40                  45              


Lys Ile Ile Lys Phe Leu Asn Glu Lys Leu Glu Lys Ser Lys Met Gln 
    50                  55                  60                  


Ser Ile Asn Glu Asp Leu Lys Asp Ile Leu His Ala Ala Lys Gln Ile 
65                  70                  75                  80  


Val Gly Xaa Asp Asn Gly Arg Glu Ala Ile Glu Ser Gly Ala Ala Phe 
                85                  90                  95      


Leu Phe Met Xaa Phe His Leu Lys Asp Ser Val Gly His Lys Glu Xaa 
            100                 105                 110         


Lys Ala Ile Lys Gln Met Phe Gly Pro Phe Pro Ser Ser Ser Ala Xaa 
        115                 120                 125             


Ala Ala Cys Asn Ala Xaa Asn Arg Ile Ile Ser His Phe Ser Gln Asp 
    130                 135                 140                 


Asp Leu Xaa Ala Leu Val Gln Met Xaa Glu Lys Glu His Gly Asp Arg 
145                 150                 155                 160 


Val Phe Phe Gly Lys Asn Leu Ala Phe Ser Phe Asp Met His Asp Leu 
                165                 170                 175     


Asp His Phe Asp Glu Leu Pro Ile Asn Gly Glu Xaa Gln Lys Xaa Ile 
            180                 185                 190         


Ser Leu Asp Tyr Lys Lys Phe Leu Asn Glu His Leu Gln Glu Ala Cys 
        195                 200                 205             


Xaa Pro Glu Leu Lys Pro Val Glu Lys Xaa Asn Gly Ser Phe Leu Trp 
    210                 215                 220                 


Cys Glu Val Glu Lys Tyr Leu Asn Ser Xaa Leu Lys Glu Met Xaa Glu 
225                 230                 235                 240 


Val Pro Arg Val Glu Asp Leu Cys Cys Xaa Leu Tyr Asp Met Leu Ala 
                245                 250                 255     


Ser Ile Lys Ser Gly Asp Glu Leu Gln Asp Glu Leu Phe Glu Leu Leu 
            260                 265                 270         


Gly Pro Glu Gly Leu Glu Leu Ile Glu Lys Leu Leu Gln Asn Arg Ile 
        275                 280                 285             


Xaa Ile Val Asp Arg Phe Leu Asn Ser Ser Asn Asp His Arg Phe Gln 
    290                 295                 300                 


Ala Leu Gln Asp Asn Cys Lys Lys Ile Leu Gly Glu Asn Ala Lys Pro 
305                 310                 315                 320 


Asn Tyr Gly Cys Gln Val Xaa Ile Gln Ser Glu Gln Glu Lys Gln Leu 
                325                 330                 335     


Met Lys Gln Tyr Arg Arg Glu Glu Lys Arg Ile Ala Arg Arg Glu Lys 
            340                 345                 350         


Lys Ala Gly Glu Asp Leu Glu Val Ser Glu Gly Leu Met Cys Phe Asp 
        355                 360                 365             


Pro Lys Glu Leu Arg Ile Gln Arg Glu Gln Ala Leu Leu Asn Ala Arg 
    370                 375                 380                 


Ser Val Pro Ile Leu Ser Arg Gln Arg Asp Ala Asp Val Glu Lys Ile 
385                 390                 395                 400 


His Tyr Pro His Val Tyr Asp Ser Gln Ala Glu Ala Met Lys Xaa Ser 
                405                 410                 415     


Ala Phe Ile Ala Gly Ala Lys Met Ile Leu Pro Glu Gly Ile Gln Arg 
            420                 425                 430         


Glu Asn Asn Lys Leu Tyr Glu Glu Val Arg Ile Pro Tyr Ser Glu Pro 
        435                 440                 445             


Met Pro Leu Ser Phe Glu Glu Lys Pro Val Tyr Ile Gln Asp Leu Asp 
    450                 455                 460                 


Glu Ile Gly Gln Leu Ala Phe Lys Gly Met Lys Arg Leu Asn Arg Ile 
465                 470                 475                 480 


Gln Ser Ile Val Phe Glu Xaa Ala Tyr Asn Xaa Asn Glu Asn Met Leu 
                485                 490                 495     


Ile Cys Ala Pro Xaa Gly Ala Gly Lys Xaa Asn Ile Ala Met Leu Xaa 
            500                 505                 510         


Val Leu His Glu Ile Arg Gln His Phe Gln Gln Gly Val Ile Lys Lys 
        515                 520                 525             


Asn Glu Phe Lys Ile Val Tyr Val Ala Pro Met Lys Ala Leu Ala Ala 
    530                 535                 540                 


Glu Met Xaa Asp Tyr Phe Ser Arg Arg Leu Glu Pro Leu Gly Ile Ile 
545                 550                 555                 560 


Val Lys Glu Leu Xaa Gly Asp Met Gln Leu Ser Lys Ser Glu Ile Leu 
                565                 570                 575     


Arg Xaa Gln Met Leu Val Xaa Xaa Pro Glu Lys Trp Asp Val Val Xaa 
            580                 585                 590         


Arg Lys Ser Val Gly Asp Val Ala Leu Ser Gln Ile Val Arg Leu Leu 
        595                 600                 605             


Ile Leu Asp Glu Val His Leu Leu His Glu Asp Arg Gly Pro Val Leu 
    610                 615                 620                 


Glu Ser Ile Val Ala Arg Xaa Leu Arg Gln Val Glu Ser Xaa Gln Ser 
625                 630                 635                 640 


Met Ile Arg Ile Leu Gly Leu Ser Ala Xaa Leu Pro Asn Tyr Leu Asp 
                645                 650                 655     


Val Ala Xaa Phe Leu His Val Asn Pro Tyr Ile Gly Leu Phe Phe Phe 
            660                 665                 670         


Asp Gly Arg Phe Arg Pro Val Pro Leu Gly Gln Xaa Phe Leu Gly Ile 
        675                 680                 685             


Lys Cys Ala Asn Lys Met Gln Gln Leu Asn Asn Met Asp Glu Val Cys 
    690                 695                 700                 


Tyr Glu Asn Val Leu Lys Gln Val Lys Ala Gly His Gln Val His Leu 
705                 710                 715                 720 


Phe Tyr Leu Leu Leu His Leu Phe Ile Cys Phe 
                725                 730     


<210> 3403
<211> 2202
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1007)..(1007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1106)..(1106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1300)..(1300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1356)..(1356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1372)..(1372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1412)..(1412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1426)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1448)..(1448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1480)..(1480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1491)..(1491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1571)..(1571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1581)..(1581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1602)..(1602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1611)..(1611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1630)..(1630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1648)..(1648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1665)..(1665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1672)..(1672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1681)..(1681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1743)..(1743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1745)..(1745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1755)..(1755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1757)..(1757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1814)..(1814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1828)..(1828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1842)..(1842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1856)..(1856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1889)..(1889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1911)..(1911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1913)..(1913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1915)..(1915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1939)..(1939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1944)..(1944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1963)..(1963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1991)..(1991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2023)..(2023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2060)..(2060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2062)..(2062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2104)..(2104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2148)..(2148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2158)..(2158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2180)..(2180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2190)..(2190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2197)..(2197)
<223> Selenocysteine

<400> 3403
Met Ala Leu Pro Arg Leu Xaa Gly Ala Leu Arg Ser Phe Ser Asn Val 
1               5                   10                  15      


Xaa Lys Gln Asp Asn Tyr Asn Glu Glu Val Ala Asp Leu Lys Ile Lys 
            20                  25                  30          


Arg Ser Lys Leu His Glu Gln Val Leu Asp Leu Gly Leu Xaa Trp Lys 
        35                  40                  45              


Lys Ile Ile Lys Phe Leu Asn Glu Lys Leu Glu Lys Ser Lys Met Gln 
    50                  55                  60                  


Ser Ile Asn Glu Asp Leu Lys Asp Ile Leu His Ala Ala Lys Gln Ile 
65                  70                  75                  80  


Val Gly Xaa Asp Asn Gly Arg Glu Ala Ile Glu Ser Gly Ala Ala Phe 
                85                  90                  95      


Leu Phe Met Xaa Phe His Leu Lys Asp Ser Val Gly His Lys Glu Xaa 
            100                 105                 110         


Lys Ala Ile Lys Gln Met Phe Gly Pro Phe Pro Ser Ser Ser Ala Xaa 
        115                 120                 125             


Ala Ala Cys Asn Ala Xaa Asn Arg Ile Ile Ser His Phe Ser Gln Asp 
    130                 135                 140                 


Asp Leu Xaa Ala Leu Val Gln Met Xaa Glu Lys Glu His Gly Asp Arg 
145                 150                 155                 160 


Val Phe Phe Gly Lys Asn Leu Ala Phe Ser Phe Asp Met His Asp Leu 
                165                 170                 175     


Asp His Phe Asp Glu Leu Pro Ile Asn Gly Glu Xaa Gln Lys Xaa Ile 
            180                 185                 190         


Ser Leu Asp Tyr Lys Lys Phe Leu Asn Glu His Leu Gln Glu Ala Cys 
        195                 200                 205             


Xaa Pro Glu Leu Lys Pro Val Glu Lys Xaa Asn Gly Ser Phe Leu Trp 
    210                 215                 220                 


Cys Glu Val Glu Lys Tyr Leu Asn Ser Xaa Leu Lys Glu Met Xaa Glu 
225                 230                 235                 240 


Val Pro Arg Val Glu Asp Leu Cys Cys Xaa Leu Tyr Asp Met Leu Ala 
                245                 250                 255     


Ser Ile Lys Ser Gly Asp Glu Leu Gln Asp Glu Leu Phe Glu Leu Leu 
            260                 265                 270         


Gly Pro Glu Gly Leu Glu Leu Ile Glu Lys Leu Leu Gln Asn Arg Ile 
        275                 280                 285             


Xaa Ile Val Asp Arg Phe Leu Asn Ser Ser Asn Asp His Arg Phe Gln 
    290                 295                 300                 


Ala Leu Gln Asp Asn Cys Lys Lys Ile Leu Gly Glu Asn Ala Lys Pro 
305                 310                 315                 320 


Asn Tyr Gly Cys Gln Val Xaa Ile Gln Ser Glu Gln Glu Lys Gln Leu 
                325                 330                 335     


Met Lys Gln Tyr Arg Arg Glu Glu Lys Arg Ile Ala Arg Arg Glu Lys 
            340                 345                 350         


Lys Ala Gly Glu Asp Leu Glu Val Ser Glu Gly Leu Met Cys Phe Asp 
        355                 360                 365             


Pro Lys Glu Leu Arg Ile Gln Arg Glu Gln Ala Leu Leu Asn Ala Arg 
    370                 375                 380                 


Ser Val Pro Ile Leu Ser Arg Gln Arg Asp Ala Asp Val Glu Lys Ile 
385                 390                 395                 400 


His Tyr Pro His Val Tyr Asp Ser Gln Ala Glu Ala Met Lys Xaa Ser 
                405                 410                 415     


Ala Phe Ile Ala Gly Ala Lys Met Ile Leu Pro Glu Gly Ile Gln Arg 
            420                 425                 430         


Glu Asn Asn Lys Leu Tyr Glu Glu Val Arg Ile Pro Tyr Ser Glu Pro 
        435                 440                 445             


Met Pro Leu Ser Phe Glu Glu Lys Pro Val Tyr Ile Gln Asp Leu Asp 
    450                 455                 460                 


Glu Ile Gly Gln Leu Ala Phe Lys Gly Met Lys Arg Leu Asn Arg Ile 
465                 470                 475                 480 


Gln Ser Ile Val Phe Glu Xaa Ala Tyr Asn Xaa Asn Glu Asn Met Leu 
                485                 490                 495     


Ile Cys Ala Pro Xaa Gly Ala Gly Lys Xaa Asn Ile Ala Met Leu Xaa 
            500                 505                 510         


Val Leu His Glu Ile Arg Gln His Phe Gln Gln Gly Val Ile Lys Lys 
        515                 520                 525             


Asn Glu Phe Lys Ile Val Tyr Val Ala Pro Met Lys Ala Leu Ala Ala 
    530                 535                 540                 


Glu Met Xaa Asp Tyr Phe Ser Arg Arg Leu Glu Pro Leu Gly Ile Ile 
545                 550                 555                 560 


Val Lys Glu Leu Xaa Gly Asp Met Gln Leu Ser Lys Ser Glu Ile Leu 
                565                 570                 575     


Arg Xaa Gln Met Leu Val Xaa Xaa Pro Glu Lys Trp Asp Val Val Xaa 
            580                 585                 590         


Arg Lys Ser Val Gly Asp Val Ala Leu Ser Gln Ile Val Arg Leu Leu 
        595                 600                 605             


Ile Leu Asp Glu Val His Leu Leu His Glu Asp Arg Gly Pro Val Leu 
    610                 615                 620                 


Glu Ser Ile Val Ala Arg Xaa Leu Arg Gln Val Glu Ser Xaa Gln Ser 
625                 630                 635                 640 


Met Ile Arg Ile Leu Gly Leu Ser Ala Xaa Leu Pro Asn Tyr Leu Asp 
                645                 650                 655     


Val Ala Xaa Phe Leu His Val Asn Pro Tyr Ile Gly Leu Phe Phe Phe 
            660                 665                 670         


Asp Gly Arg Phe Arg Pro Val Pro Leu Gly Gln Xaa Phe Leu Gly Ile 
        675                 680                 685             


Lys Cys Ala Asn Lys Met Gln Gln Leu Asn Asn Met Asp Glu Val Cys 
    690                 695                 700                 


Tyr Glu Asn Val Leu Lys Gln Val Lys Ala Gly His Gln Val Met Val 
705                 710                 715                 720 


Phe Val His Ala Arg Asn Ala Xaa Val Arg Xaa Ala Met Ser Leu Ile 
                725                 730                 735     


Glu Arg Ala Lys Asn Cys Gly His Ile Pro Phe Phe Phe Pro Xaa Gln 
            740                 745                 750         


Gly His Asp Tyr Val Leu Ala Glu Lys Gln Val Gln Arg Ser Arg Asn 
        755                 760                 765             


Lys Gln Val Arg Glu Leu Phe Pro Asp Gly Phe Ser Ile His His Ala 
    770                 775                 780                 


Gly Met Leu Arg Gln Asp Arg Asn Leu Val Glu Asn Leu Phe Ser Asn 
785                 790                 795                 800 


Gly His Ile Lys Val Leu Val Cys Xaa Ala Xaa Leu Ala Trp Gly Val 
                805                 810                 815     


Asn Leu Pro Ala His Ala Val Ile Ile Lys Gly Xaa Gln Ile Tyr Ala 
            820                 825                 830         


Ala Lys Arg Gly Ser Phe Val Asp Leu Gly Ile Leu Asp Val Met Gln 
        835                 840                 845             


Ile Phe Gly Arg Ala Gly Arg Pro Gln Phe Asp Lys Phe Gly Glu Gly 
    850                 855                 860                 


Ile Ile Ile Xaa Xaa His Asp Lys Leu Ser His Tyr Leu Xaa Leu Leu 
865                 870                 875                 880 


Xaa Gln Arg Asn Pro Ile Glu Ser Gln Phe Leu Glu Ser Leu Ala Asp 
                885                 890                 895     


Asn Leu Asn Ala Glu Ile Ala Leu Gly Xaa Val Xaa Asn Val Glu Glu 
            900                 905                 910         


Ala Val Lys Trp Ile Ser Tyr Xaa Tyr Leu Tyr Val Arg Met Arg Ala 
        915                 920                 925             


Asn Pro Leu Ala Tyr Gly Ile Ser His Lys Ala Tyr Gln Ile Asp Pro 
    930                 935                 940                 


Xaa Leu Arg Lys His Arg Glu Gln Leu Val Ile Glu Val Gly Arg Lys 
945                 950                 955                 960 


Leu Asp Lys Ala Gln Met Ile Arg Phe Glu Glu Arg Xaa Gly Tyr Phe 
                965                 970                 975     


Ser Ser Xaa Asp Leu Gly Arg Xaa Ala Ser His Tyr Tyr Ile Lys Tyr 
            980                 985                 990         


Asn Xaa Ile Glu Xaa Phe Asn Glu  Leu Phe Asp Ala His  Lys Xaa Glu 
        995                 1000                 1005             


Gly Asp  Ile Phe Ala Ile Val  Ser Lys Ala Glu Glu  Phe Asp Gln 
    1010                 1015                 1020             


Ile Lys  Val Arg Glu Glu Glu  Ile Glu Glu Leu Asp  Xaa Leu Leu 
    1025                 1030                 1035             


Ser Asn  Phe Cys Glu Leu Ser  Xaa Pro Gly Gly Val  Glu Asn Ser 
    1040                 1045                 1050             


Tyr Gly  Lys Ile Asn Ile Leu  Leu Gln Xaa Tyr Ile  Ser Arg Gly 
    1055                 1060                 1065             


Glu Met  Asp Ser Phe Ser Leu  Ile Ser Asp Ser Ala  Tyr Val Ala 
    1070                 1075                 1080             


Gln Asn  Ala Ala Arg Ile Val  Arg Ala Leu Phe Glu  Ile Ala Leu 
    1085                 1090                 1095             


Arg Lys  Arg Trp Pro Xaa Met  Xaa Tyr Arg Leu Leu  Asn Leu Ser 
    1100                 1105                 1110             


Lys Val  Ile Asp Lys Arg Leu  Trp Gly Trp Ala Ser  Pro Leu Arg 
    1115                 1120                 1125             


Gln Phe  Ser Ile Leu Pro Pro  His Ile Leu Xaa Arg  Leu Glu Glu 
    1130                 1135                 1140             


Lys Lys  Leu Xaa Val Asp Lys  Leu Lys Asp Met Arg  Lys Asp Glu 
    1145                 1150                 1155             


Ile Gly  His Ile Leu His His  Val Asn Ile Gly Leu  Lys Val Lys 
    1160                 1165                 1170             


Gln Cys  Val His Gln Ile Pro  Ser Val Met Met Glu  Ala Ser Ile 
    1175                 1180                 1185             


Gln Pro  Ile Xaa Arg Xaa Val  Leu Arg Val Xaa Leu  Ser Ile Tyr 
    1190                 1195                 1200             


Ala Asp  Phe Xaa Trp Asn Asp  Gln Val His Gly Xaa  Val Gly Glu 
    1205                 1210                 1215             


Pro Trp  Trp Ile Trp Val Glu  Asp Pro Xaa Asn Asp  His Ile Tyr 
    1220                 1225                 1230             


His Ser  Glu Tyr Phe Leu Ala  Leu Lys Lys Gln Val  Ile Ser Lys 
    1235                 1240                 1245             


Glu Ala  Gln Leu Leu Val Phe  Xaa Ile Pro Ile Phe  Glu Pro Leu 
    1250                 1255                 1260             


Pro Ser  Gln Tyr Tyr Ile Arg  Ala Val Ser Asp Arg  Trp Leu Gly 
    1265                 1270                 1275             


Ala Glu  Ala Val Cys Ile Ile  Asn Phe Gln His Leu  Ile Leu Pro 
    1280                 1285                 1290             


Glu Arg  His Pro Pro His Xaa  Glu Leu Leu Asp Leu  Gln Pro Leu 
    1295                 1300                 1305             


Pro Ile  Xaa Ala Leu Gly Cys  Lys Ala Tyr Glu Ala  Leu Tyr Asn 
    1310                 1315                 1320             


Phe Ser  His Phe Asn Pro Val  Gln Xaa Gln Ile Phe  His Xaa Leu 
    1325                 1330                 1335             


Tyr His  Xaa Asp Cys Asn Val  Leu Leu Gly Ala Pro  Xaa Gly Ser 
    1340                 1345                 1350             


Gly Lys  Xaa Val Ala Ala Glu  Leu Ala Ile Phe Arg  Val Phe Asn 
    1355                 1360                 1365             


Lys Tyr  Pro Xaa Ser Lys Ala  Val Tyr Ile Ala Pro  Leu Lys Ala 
    1370                 1375                 1380             


Leu Val  Arg Glu Arg Met Asp  Asp Trp Lys Val Arg  Ile Glu Glu 
    1385                 1390                 1395             


Lys Leu  Gly Lys Lys Val Ile  Glu Leu Xaa Gly Asp  Val Xaa Pro 
    1400                 1405                 1410             


Asp Met  Lys Ser Ile Ala Lys  Ala Asp Leu Ile Val  Xaa Xaa Pro 
    1415                 1420                 1425             


Glu Lys  Trp Asp Gly Val Ser  Arg Ser Trp Gln Asn  Arg Asn Tyr 
    1430                 1435                 1440             


Val Gln  Gln Val Xaa Ile Leu  Ile Ile Asp Glu Ile  His Leu Leu 
    1445                 1450                 1455             


Gly Glu  Glu Arg Gly Pro Val  Leu Glu Val Ile Val  Ser Arg Xaa 
    1460                 1465                 1470             


Asn Phe  Ile Ser Ser His Xaa  Glu Lys Pro Val Arg  Ile Val Gly 
    1475                 1480                 1485             


Leu Ser  Xaa Ala Leu Ala Asn  Ala Arg Asp Leu Ala  Asp Trp Leu 
    1490                 1495                 1500             


Asn Ile  Lys Gln Met Gly Leu  Phe Asn Phe Arg Pro  Ser Val Arg 
    1505                 1510                 1515             


Pro Val  Pro Leu Glu Val His  Ile Gln Gly Phe Pro  Gly Gln His 
    1520                 1525                 1530             


Tyr Cys  Pro Arg Met Ala Ser  Met Asn Lys Pro Ala  Phe Gln Ala 
    1535                 1540                 1545             


Ile Arg  Ser His Ser Pro Ala  Lys Pro Val Leu Ile  Phe Val Ser 
    1550                 1555                 1560             


Ser Arg  Arg Gln Xaa Arg Leu  Xaa Ala Leu Glu Leu  Ile Ala Phe 
    1565                 1570                 1575             


Leu Ala  Xaa Glu Glu Asp Pro  Lys Gln Trp Leu Asn  Met Asp Glu 
    1580                 1585                 1590             


Arg Glu  Met Glu Asn Ile Ile  Ala Xaa Val Arg Asp  Ser Asn Leu 
    1595                 1600                 1605             


Lys Leu  Xaa Leu Ala Phe Gly  Ile Gly Met His His  Ala Gly Leu 
    1610                 1615                 1620             


His Glu  Arg Asp Arg Lys Xaa  Val Glu Glu Leu Phe  Val Asn Cys 
    1625                 1630                 1635             


Lys Val  Gln Val Leu Ile Ala  Xaa Ser Xaa Leu Ala  Trp Gly Val 
    1640                 1645                 1650             


Asn Phe  Pro Ala His Leu Val  Ile Ile Lys Gly Xaa  Glu Tyr Tyr 
    1655                 1660                 1665             


Asp Gly  Lys Xaa Arg Arg Tyr  Val Asp Phe Pro Ile  Xaa Asp Val 
    1670                 1675                 1680             


Leu Gln  Met Met Gly Arg Ala  Gly Arg Pro Gln Phe  Asp Asp Gln 
    1685                 1690                 1695             


Gly Lys  Ala Val Ile Leu Val  His Asp Ile Lys Lys  Asp Phe Tyr 
    1700                 1705                 1710             


Lys Lys  Phe Leu Tyr Glu Pro  Phe Pro Val Glu Ser  Ser Leu Leu 
    1715                 1720                 1725             


Gly Val  Leu Ser Asp His Leu  Asn Ala Glu Ile Ala  Gly Gly Xaa 
    1730                 1735                 1740             


Ile Xaa  Ser Lys Gln Asp Ala  Leu Asp Tyr Ile Xaa  Trp Xaa Tyr 
    1745                 1750                 1755             


Phe Phe  Arg Arg Leu Ile Met  Asn Pro Ser Tyr Tyr  Asn Leu Gly 
    1760                 1765                 1770             


Asp Val  Ser His Asp Ser Val  Asn Lys Phe Leu Ser  His Leu Ile 
    1775                 1780                 1785             


Glu Lys  Ser Leu Ile Glu Leu  Glu Leu Ser Tyr Cys  Ile Glu Ile 
    1790                 1795                 1800             


Gly Glu  Asp Asn Arg Ser Ile  Glu Pro Leu Xaa Tyr  Gly Arg Ile 
    1805                 1810                 1815             


Ala Ser  Tyr Tyr Tyr Leu Lys  His Gln Xaa Val Lys  Met Phe Lys 
    1820                 1825                 1830             


Asp Arg  Leu Lys Pro Glu Cys  Ser Xaa Glu Glu Leu  Leu Ser Ile 
    1835                 1840                 1845             


Leu Ser  Asp Ala Glu Glu Tyr  Xaa Asp Leu Pro Val  Arg His Asn 
    1850                 1855                 1860             


Glu Asp  His Met Asn Ser Glu  Leu Ala Lys Cys Leu  Pro Ile Glu 
    1865                 1870                 1875             


Ser Asn  Pro His Ser Phe Asp  Ser Pro His Xaa Lys  Ala His Leu 
    1880                 1885                 1890             


Leu Leu  Gln Ala His Leu Ser  Arg Ala Met Leu Pro  Cys Pro Asp 
    1895                 1900                 1905             


Tyr Asp  Xaa Asp Xaa Lys Xaa  Val Leu Asp Gln Ala  Leu Arg Val 
    1910                 1915                 1920             


Cys Gln  Ala Met Leu Asp Val  Ala Ala Asn Gln Gly  Trp Leu Val 
    1925                 1930                 1935             


Xaa Val  Leu Asn Ile Xaa Asn  Leu Ile Gln Met Val  Ile Gln Gly 
    1940                 1945                 1950             


Arg Trp  Leu Lys Asp Ser Ser  Leu Leu Xaa Leu Pro  Asn Ile Glu 
    1955                 1960                 1965             


Asn His  His Leu His Leu Phe  Lys Lys Trp Lys Pro  Ile Met Lys 
    1970                 1975                 1980             


Gly Pro  His Ala Arg Gly Arg  Xaa Ser Ile Glu Ser  Leu Pro Glu 
    1985                 1990                 1995             


Leu Ile  His Ala Cys Gly Gly  Lys Asp His Val Phe  Ser Ser Met 
    2000                 2005                 2010             


Val Glu  Ser Glu Leu His Ala  Ala Lys Xaa Lys Gln  Ala Trp Asn 
    2015                 2020                 2025             


Phe Leu  Ser His Leu Pro Val  Ile Asn Val Gly Ile  Ser Val Lys 
    2030                 2035                 2040             


Gly Ser  Trp Asp Asp Leu Val  Glu Gly His Asn Glu  Leu Ser Val 
    2045                 2050                 2055             


Ser Xaa  Leu Xaa Ala Asp Lys  Arg Asp Asp Asn Lys  Trp Ile Lys 
    2060                 2065                 2070             


Leu His  Ala Asp Gln Glu Tyr  Val Leu Gln Val Ser  Leu Gln Arg 
    2075                 2080                 2085             


Val His  Phe Gly Phe His Lys  Gly Lys Pro Glu Ser  Cys Ala Val 
    2090                 2095                 2100             


Xaa Pro  Arg Phe Pro Lys Ser  Lys Asp Glu Gly Trp  Phe Leu Ile 
    2105                 2110                 2115             


Leu Gly  Glu Val Asp Lys Arg  Glu Leu Ile Ala Leu  Lys Arg Val 
    2120                 2125                 2130             


Gly Tyr  Ile Arg Asn His His  Val Ala Ser Leu Ser  Phe Tyr Xaa 
    2135                 2140                 2145             


Pro Glu  Ile Pro Gly Arg Tyr  Ile Tyr Xaa Leu Tyr  Phe Met Ser 
    2150                 2155                 2160             


Asp Cys  Tyr Leu Gly Leu Asp  Gln Gln Tyr Asp Ile  Tyr Leu Asn 
    2165                 2170                 2175             


Val Xaa  Gln Ala Ser Leu Ser  Ala Gln Val Asn Xaa  Lys Val Ser 
    2180                 2185                 2190             


Asp Ser  Leu Xaa Asp Leu Ala  Leu Lys 
    2195                 2200         


<210> 3404
<211> 48
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<400> 3404
Met Ala Leu Pro Arg Leu Xaa Gly Ala Leu Arg Ser Phe Ser Asn Val 
1               5                   10                  15      


Xaa Lys Gln Asp Asn Tyr Asn Glu Glu Val Ala Asp Leu Lys Leu Glu 
            20                  25                  30          


Leu Ile Met Gly Glu Lys Gln Leu Lys Val Gly Leu His Phe Ser Ser 
        35                  40                  45              


<210> 3405
<211> 236
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<400> 3405
Met Glu Ser Ser Ala Lys Met Glu Ser Gly Gly Ala Gly Gln Gln Pro 
1               5                   10                  15      


Gln Pro Gln Pro Gln Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe 
            20                  25                  30          


Ala Xaa Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln 
        35                  40                  45              


Ser Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Pro 
    50                  55                  60                  


Gln Leu Arg Pro Ala Ala Asp Gly Gln Pro Ser Gly Gly Gly His Lys 
65                  70                  75                  80  


Ser Ala Pro Lys Gln Val Lys Arg Gln Arg Ser Ser Ser Pro Glu Leu 
                85                  90                  95      


Met Arg Cys Lys Arg Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu 
            100                 105                 110         


Pro Gln Gln Gln Pro Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg 
        115                 120                 125             


Asn Arg Val Lys Leu Val Asn Leu Gly Phe Ala Xaa Leu Arg Glu His 
    130                 135                 140                 


Val Pro Asn Gly Ala Ala Asn Lys Lys Met Ser Lys Val Glu Xaa Leu 
145                 150                 155                 160 


Arg Ser Ala Val Glu Tyr Ile Arg Ala Leu Gln Gln Leu Leu Asp Glu 
                165                 170                 175     


His Asp Ala Val Ser Ala Ala Phe Gln Ala Gly Val Leu Ser Pro Xaa 
            180                 185                 190         


Ile Ser Pro Asn Tyr Ser Asn Asp Leu Asn Ser Met Ala Gly Ser Pro 
        195                 200                 205             


Val Ser Ser Tyr Ser Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ser Pro 
    210                 215                 220                 


Glu Glu Gln Glu Leu Leu Asp Phe Xaa Asn Trp Phe 
225                 230                 235     


<210> 3406
<211> 193
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(137)
<223> Selenocysteine

<400> 3406
Met Asp Gly Gly Xaa Leu Pro Arg Ser Ala Pro Pro Ala Pro Pro Val 
1               5                   10                  15      


Pro Val Gly Cys Ala Ala Arg Arg Arg Pro Ala Ser Pro Glu Leu Leu 
            20                  25                  30          


Arg Cys Ser Arg Arg Arg Arg Pro Ala Xaa Ala Glu Xaa Gly Gly Gly 
        35                  40                  45              


Ala Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg Asn Arg Val Lys 
    50                  55                  60                  


Leu Val Asn Leu Gly Phe Gln Ala Leu Arg Gln His Val Pro His Gly 
65                  70                  75                  80  


Gly Ala Ser Lys Lys Leu Ser Lys Val Glu Xaa Leu Arg Ser Ala Val 
                85                  90                  95      


Glu Tyr Ile Arg Ala Leu Gln Arg Leu Leu Ala Glu His Asp Ala Val 
            100                 105                 110         


Arg Asn Ala Leu Ala Gly Gly Leu Arg Pro Gln Ala Val Arg Pro Ser 
        115                 120                 125             


Ala Pro Arg Gly Pro Pro Gly Xaa Xaa Pro Val Ala Ala Ser Pro Ser 
    130                 135                 140                 


Arg Ala Ser Ser Ser Pro Gly Arg Gly Gly Ser Ser Glu Pro Gly Ser 
145                 150                 155                 160 


Pro Arg Ser Ala Tyr Ser Ser Asp Asp Ser Gly Cys Glu Gly Ala Leu 
                165                 170                 175     


Ser Pro Ala Glu Arg Glu Leu Leu Asp Phe Ser Ser Trp Leu Gly Gly 
            180                 185                 190         


Tyr 
    


<210> 3407
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(170)
<223> Selenocysteine

<400> 3407
Met Met Asp Asn Arg Gly Asn Ser Ser Leu Pro Asp Lys Leu Pro Ile 
1               5                   10                  15      


Phe Pro Asp Ser Ala Arg Leu Pro Leu Xaa Arg Ser Phe Tyr Leu Glu 
            20                  25                  30          


Pro Met Val Xaa Phe His Val His Pro Glu Ala Pro Val Ser Ser Pro 
        35                  40                  45              


Tyr Ser Glu Glu Leu Pro Arg Leu Pro Phe Pro Ser Asp Ser Leu Ile 
    50                  55                  60                  


Leu Gly Asn Tyr Ser Glu Pro Cys Pro Phe Ser Phe Pro Met Pro Tyr 
65                  70                  75                  80  


Pro Asn Tyr Arg Gly Cys Glu Tyr Ser Tyr Gly Pro Ala Phe Xaa Arg 
                85                  90                  95      


Lys Arg Asn Glu Arg Glu Arg Gln Arg Val Lys Cys Val Asn Glu Gly 
            100                 105                 110         


Tyr Ala Gln Leu Arg His His Leu Pro Glu Glu Tyr Leu Glu Lys Arg 
        115                 120                 125             


Leu Ser Lys Val Glu Xaa Leu Arg Ala Ala Ile Lys Tyr Ile Asn Tyr 
    130                 135                 140                 


Leu Gln Ser Leu Leu Tyr Pro Asp Lys Ala Glu Xaa Lys Asn Asn Pro 
145                 150                 155                 160 


Gly Lys Val Ser Ser Met Ile Ala Xaa Xaa Ser His His Ala Asp Pro 
                165                 170                 175     


Met Phe Arg Ile Val 
            180     


<210> 3408
<211> 173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<400> 3408
Met Met Glu Xaa Arg Lys Pro Ala Glu Arg Leu Ala Leu Pro Tyr Ser 
1               5                   10                  15      


Leu Arg Xaa Ala Pro Leu Gly Val Pro Gly Xaa Leu Pro Gly Leu Pro 
            20                  25                  30          


Arg Arg Asp Pro Leu Arg Val Ala Leu Arg Leu Asp Ala Ala Cys Trp 
        35                  40                  45              


Glu Trp Ala Arg Ser Gly Cys Ala Arg Gly Trp Gln Tyr Leu Pro Val 
    50                  55                  60                  


Pro Leu Asp Ser Ala Phe Glu Pro Ala Phe Leu Arg Lys Arg Asn Glu 
65                  70                  75                  80  


Arg Glu Arg Gln Arg Val Arg Cys Val Asn Glu Gly Tyr Ala Arg Leu 
                85                  90                  95      


Arg Asp His Leu Pro Arg Glu Leu Ala Asp Lys Arg Leu Ser Lys Val 
            100                 105                 110         


Glu Xaa Leu Arg Ala Ala Ile Asp Tyr Ile Lys His Leu Gln Glu Leu 
        115                 120                 125             


Leu Glu Arg Gln Ala Trp Gly Leu Glu Gly Ala Ala Gly Ala Val Pro 
    130                 135                 140                 


Gln Arg Arg Ala Glu Cys Asn Ser Asp Gly Glu Ser Lys Ala Ser Ser 
145                 150                 155                 160 


Ala Pro Ser Pro Ser Ser Glu Pro Glu Glu Gly Gly Ser 
                165                 170             


<210> 3409
<211> 206
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 3409
Met Asn Asn Asn Phe Cys Arg Ala Leu Val Asp Arg Arg Pro Leu Gly 
1               5                   10                  15      


Pro Pro Ser Cys Met Gln Leu Gly Val Met Pro Pro Pro Arg Gln Ala 
            20                  25                  30          


Pro Leu Pro Pro Ala Glu Pro Leu Gly Asn Val Pro Phe Leu Leu Tyr 
        35                  40                  45              


Pro Gly Pro Ala Glu Pro Pro Tyr Tyr Asp Ala Tyr Ala Gly Val Phe 
    50                  55                  60                  


Pro Tyr Val Pro Phe Pro Gly Ala Phe Gly Val Tyr Glu Tyr Pro Phe 
65                  70                  75                  80  


Glu Pro Ala Phe Ile Gln Lys Arg Asn Glu Arg Glu Arg Gln Arg Val 
                85                  90                  95      


Lys Cys Val Asn Glu Gly Tyr Ala Arg Leu Arg Gly His Leu Pro Gly 
            100                 105                 110         


Ala Leu Ala Glu Lys Arg Leu Ser Lys Val Glu Xaa Leu Arg Ala Ala 
        115                 120                 125             


Ile Arg Tyr Ile Lys Tyr Leu Gln Glu Leu Leu Ser Ser Ala Pro Asp 
    130                 135                 140                 


Gly Ser Xaa Pro Pro Ala Ser Arg Gly Leu Pro Gly Xaa Gly Pro Cys 
145                 150                 155                 160 


Pro Ala Pro Pro Ala Xaa Pro Arg Pro Asp Arg Pro Gly Asp Gly Glu 
                165                 170                 175     


Ala Arg Ala Pro Ser Ser Leu Val Pro Glu Ser Ser Glu Ser Ser Cys 
            180                 185                 190         


Phe Ser Pro Ser Pro Phe Leu Glu Ser Glu Glu Ser Trp His 
        195                 200                 205     


<210> 3410
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<400> 3410
Met Ala Lys Asp Phe Gln Asp Ile Gln Gln Leu Ser Ser Glu Glu Asn 
1               5                   10                  15      


Asp His Pro Phe His Gln Gly Glu Gly Pro Gly Xaa Arg Arg Leu Asn 
            20                  25                  30          


Pro Arg Arg Gly Asn Pro Phe Leu Lys Gly Pro Pro Pro Ala Gln Pro 
        35                  40                  45              


Leu Ala Gln Arg Leu Cys Ser Met Val Cys Phe Ser Leu Leu Ala Leu 
    50                  55                  60                  


Ser Phe Asn Ile Leu Leu Leu Val Val Ile Cys Val Xaa Gly Ser Gln 
65                  70                  75                  80  


Ser Ala Gln Leu Gln Ala Glu Leu Arg Ser Leu Lys Glu Ala Phe Ser 
                85                  90                  95      


Asn Phe Ser Ser Ser Xaa Leu Xaa Glu Val Gln Ala Ile Ser Xaa His 
            100                 105                 110         


Gly Gly Ser Val Gly Asp Lys Ile Xaa Ser Leu Gly Ala Lys Leu Glu 
        115                 120                 125             


Lys Gln Gln Gln Asp Leu Lys 
    130                 135 


<210> 3411
<211> 311
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<400> 3411
Met Ala Lys Asp Phe Gln Asp Ile Gln Gln Leu Ser Ser Glu Glu Asn 
1               5                   10                  15      


Asp His Pro Phe His Gln Gly Glu Gly Pro Gly Xaa Arg Arg Leu Asn 
            20                  25                  30          


Pro Arg Arg Gly Asn Pro Phe Leu Lys Gly Pro Pro Pro Ala Gln Pro 
        35                  40                  45              


Leu Ala Gln Arg Leu Cys Ser Met Val Cys Phe Ser Leu Leu Ala Leu 
    50                  55                  60                  


Ser Phe Asn Ile Leu Leu Leu Val Val Ile Cys Val Xaa Gly Ser Gln 
65                  70                  75                  80  


Ser Glu Gly His Gly Gly Ala Gln Leu Gln Ala Glu Leu Arg Ser Leu 
                85                  90                  95      


Lys Glu Ala Phe Ser Asn Phe Ser Ser Ser Xaa Leu Xaa Glu Val Gln 
            100                 105                 110         


Ala Ile Ser Xaa His Gly Gly Ser Val Gly Asp Lys Ile Xaa Ser Leu 
        115                 120                 125             


Gly Ala Lys Leu Glu Lys Gln Gln Gln Asp Leu Lys Ala Asp His Asp 
    130                 135                 140                 


Ala Leu Leu Phe His Leu Lys His Phe Pro Val Asp Leu Arg Phe Val 
145                 150                 155                 160 


Ala Cys Gln Met Glu Leu Leu His Ser Asn Gly Ser Gln Arg Xaa Cys 
                165                 170                 175     


Cys Pro Val Asn Trp Val Glu His Gln Gly Ser Cys Tyr Trp Phe Ser 
            180                 185                 190         


His Ser Gly Lys Ala Trp Ala Glu Ala Glu Lys Tyr Cys Gln Leu Glu 
        195                 200                 205             


Asn Ala His Leu Val Val Ile Asn Ser Trp Glu Glu Gln Lys Phe Ile 
    210                 215                 220                 


Val Gln His Xaa Asn Pro Phe Asn Xaa Trp Ile Gly Leu Xaa Asp Ser 
225                 230                 235                 240 


Asp Gly Ser Trp Lys Trp Val Asp Gly Xaa Asp Tyr Arg His Asn Tyr 
                245                 250                 255     


Lys Asn Trp Ala Val Xaa Gln Pro Asp Asn Trp His Gly His Glu Leu 
            260                 265                 270         


Gly Gly Ser Glu Asp Cys Val Glu Val Gln Pro Asp Gly Arg Trp Asn 
        275                 280                 285             


Asp Asp Phe Cys Leu Gln Val Tyr Arg Trp Val Cys Glu Lys Arg Arg 
    290                 295                 300                 


Asn Ala Xaa Gly Glu Val Ala 
305                 310     


<210> 3412
<211> 287
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<400> 3412
Met Ala Lys Asp Phe Gln Asp Ile Gln Gln Leu Ser Ser Glu Glu Asn 
1               5                   10                  15      


Asp His Pro Phe His Gln Gly Pro Pro Pro Ala Gln Pro Leu Ala Gln 
            20                  25                  30          


Arg Leu Cys Ser Met Val Cys Phe Ser Leu Leu Ala Leu Ser Phe Asn 
        35                  40                  45              


Ile Leu Leu Leu Val Val Ile Cys Val Xaa Gly Ser Gln Ser Ala Gln 
    50                  55                  60                  


Leu Gln Ala Glu Leu Arg Ser Leu Lys Glu Ala Phe Ser Asn Phe Ser 
65                  70                  75                  80  


Ser Ser Xaa Leu Xaa Glu Val Gln Ala Ile Ser Xaa His Gly Gly Ser 
                85                  90                  95      


Val Gly Asp Lys Ile Xaa Ser Leu Gly Ala Lys Leu Glu Lys Gln Gln 
            100                 105                 110         


Gln Asp Leu Lys Ala Asp His Asp Ala Leu Leu Phe His Leu Lys His 
        115                 120                 125             


Phe Pro Val Asp Leu Arg Phe Val Ala Cys Gln Met Glu Leu Leu His 
    130                 135                 140                 


Ser Asn Gly Ser Gln Arg Xaa Cys Cys Pro Val Asn Trp Val Glu His 
145                 150                 155                 160 


Gln Gly Ser Cys Tyr Trp Phe Ser His Ser Gly Lys Ala Trp Ala Glu 
                165                 170                 175     


Ala Glu Lys Tyr Cys Gln Leu Glu Asn Ala His Leu Val Val Ile Asn 
            180                 185                 190         


Ser Trp Glu Glu Gln Lys Phe Ile Val Gln His Xaa Asn Pro Phe Asn 
        195                 200                 205             


Xaa Trp Ile Gly Leu Xaa Asp Ser Asp Gly Ser Trp Lys Trp Val Asp 
    210                 215                 220                 


Gly Xaa Asp Tyr Arg His Asn Tyr Lys Asn Trp Ala Val Xaa Gln Pro 
225                 230                 235                 240 


Asp Asn Trp His Gly His Glu Leu Gly Gly Ser Glu Asp Cys Val Glu 
                245                 250                 255     


Val Gln Pro Asp Gly Arg Trp Asn Asp Asp Phe Cys Leu Gln Val Tyr 
            260                 265                 270         


Arg Trp Val Cys Glu Lys Arg Arg Asn Ala Xaa Gly Glu Val Ala 
        275                 280                 285         


<210> 3413
<211> 292
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<400> 3413
Met Ala Lys Asp Phe Gln Asp Ile Gln Gln Leu Ser Ser Glu Glu Asn 
1               5                   10                  15      


Asp His Pro Phe His Gln Gly Pro Pro Pro Ala Gln Pro Leu Ala Gln 
            20                  25                  30          


Arg Leu Cys Ser Met Val Cys Phe Ser Leu Leu Ala Leu Ser Phe Asn 
        35                  40                  45              


Ile Leu Leu Leu Val Val Ile Cys Val Xaa Gly Ser Gln Ser Glu Gly 
    50                  55                  60                  


His Gly Gly Ala Gln Leu Gln Ala Glu Leu Arg Ser Leu Lys Glu Ala 
65                  70                  75                  80  


Phe Ser Asn Phe Ser Ser Ser Xaa Leu Xaa Glu Val Gln Ala Ile Ser 
                85                  90                  95      


Xaa His Gly Gly Ser Val Gly Asp Lys Ile Xaa Ser Leu Gly Ala Lys 
            100                 105                 110         


Leu Glu Lys Gln Gln Gln Asp Leu Lys Ala Asp His Asp Ala Leu Leu 
        115                 120                 125             


Phe His Leu Lys His Phe Pro Val Asp Leu Arg Phe Val Ala Cys Gln 
    130                 135                 140                 


Met Glu Leu Leu His Ser Asn Gly Ser Gln Arg Xaa Cys Cys Pro Val 
145                 150                 155                 160 


Asn Trp Val Glu His Gln Gly Ser Cys Tyr Trp Phe Ser His Ser Gly 
                165                 170                 175     


Lys Ala Trp Ala Glu Ala Glu Lys Tyr Cys Gln Leu Glu Asn Ala His 
            180                 185                 190         


Leu Val Val Ile Asn Ser Trp Glu Glu Gln Lys Phe Ile Val Gln His 
        195                 200                 205             


Xaa Asn Pro Phe Asn Xaa Trp Ile Gly Leu Xaa Asp Ser Asp Gly Ser 
    210                 215                 220                 


Trp Lys Trp Val Asp Gly Xaa Asp Tyr Arg His Asn Tyr Lys Asn Trp 
225                 230                 235                 240 


Ala Val Xaa Gln Pro Asp Asn Trp His Gly His Glu Leu Gly Gly Ser 
                245                 250                 255     


Glu Asp Cys Val Glu Val Gln Pro Asp Gly Arg Trp Asn Asp Asp Phe 
            260                 265                 270         


Cys Leu Gln Val Tyr Arg Trp Val Cys Glu Lys Arg Arg Asn Ala Xaa 
        275                 280                 285             


Gly Glu Val Ala 
    290         


<210> 3414
<211> 2964
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1184)..(1184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1237)..(1237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1304)..(1304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1392)..(1392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1418)..(1419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1454)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1465)..(1465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1504)..(1504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1592)..(1592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1604)..(1604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1608)..(1608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1628)..(1628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1639)..(1639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1659)..(1659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1666)..(1666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1678)..(1678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1683)..(1683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1692)..(1692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1695)..(1695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1758)..(1758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1771)..(1771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1819)..(1819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1841)..(1841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1892)..(1892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1894)..(1894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1925)..(1925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1957)..(1957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1967)..(1967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2001)..(2002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2019)..(2019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2089)..(2090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2100)..(2100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2121)..(2121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2156)..(2156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2249)..(2249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2252)..(2252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2290)..(2290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2300)..(2300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2334)..(2334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2336)..(2336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2339)..(2339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2379)..(2379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2390)..(2390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2409)..(2409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2416)..(2416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2422)..(2422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2490)..(2490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2497)..(2497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2502)..(2502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2556)..(2556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2565)..(2565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2673)..(2673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2723)..(2723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2753)..(2753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2761)..(2761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2801)..(2801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2814)..(2814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2885)..(2885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2895)..(2895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2905)..(2905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2907)..(2907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2939)..(2939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2954)..(2954)
<223> Selenocysteine

<400> 3414
Met Asp Pro Arg Asn Xaa Ala Met Leu Gly Leu Gly Ser Asp Ser Glu 
1               5                   10                  15      


Gly Phe Ser Arg Lys Ser Pro Ser Ala Ile Ser Xaa Gly Xaa Leu Val 
            20                  25                  30          


Ser Lys Arg Glu Val Glu Leu Glu Lys Asn Xaa Lys Glu Glu Glu Asp 
        35                  40                  45              


Leu Arg Lys Arg Asn Arg Glu Arg Asn Ile Glu Ala Gly Lys Asp Asp 
    50                  55                  60                  


Gly Leu Xaa Asp Ala Gln Gln Gln Phe Ser Val Lys Glu Xaa Asn Phe 
65                  70                  75                  80  


Ser Glu Gly Asn Leu Lys Leu Lys Ile Gly Leu Gln Ala Lys Arg Xaa 
                85                  90                  95      


Lys Lys Pro Pro Lys Asn Leu Glu Asn Tyr Val Cys Arg Pro Ala Ile 
            100                 105                 110         


Lys Xaa Xaa Ile Lys His Pro Arg Lys Ala Leu Lys Ser Gly Lys Met 
        115                 120                 125             


Xaa Asp Glu Lys Asn Glu His Cys Pro Ser Lys Arg Asp Pro Ser Lys 
    130                 135                 140                 


Leu Tyr Lys Lys Ala Asp Asp Val Ala Ala Ile Glu Cys Gln Ser Glu 
145                 150                 155                 160 


Glu Val Ile Arg Leu His Ser Gln Gly Glu Asn Asn Pro Leu Ser Lys 
                165                 170                 175     


Lys Leu Ser Pro Val His Ser Glu Met Ala Asp Tyr Ile Asn Ala Xaa 
            180                 185                 190         


Pro Ser Xaa Leu Leu Gly Ser Arg Asp Pro Asp Leu Lys Asp Arg Ala 
        195                 200                 205             


Leu Leu Asn Gly Gly Xaa Ser Val Xaa Glu Lys Leu Ala Gln Leu Ile 
    210                 215                 220                 


Ala Xaa Cys Pro Pro Ser Lys Ser Ser Lys Xaa Lys Pro Lys Lys Leu 
225                 230                 235                 240 


Gly Xaa Gly Xaa Xaa Ala Gly Leu Val Ser Lys Asp Leu Ile Arg Lys 
                245                 250                 255     


Ala Gly Val Gly Ser Val Ala Gly Ile Ile His Lys Asp Leu Ile Lys 
            260                 265                 270         


Lys Pro Xaa Ile Ser Xaa Ala Val Gly Leu Val Xaa Lys Asp Pro Gly 
        275                 280                 285             


Lys Lys Pro Val Phe Asn Ala Ala Val Gly Leu Val Asn Lys Asp Ser 
    290                 295                 300                 


Val Lys Lys Leu Gly Xaa Gly Xaa Xaa Ala Val Phe Ile Asn Lys Asn 
305                 310                 315                 320 


Leu Gly Lys Lys Pro Gly Xaa Ile Xaa Xaa Val Gly Leu Leu Ser Lys 
                325                 330                 335     


Asp Ser Gly Lys Lys Leu Gly Ile Gly Ile Val Pro Gly Leu Val His 
            340                 345                 350         


Lys Glu Ser Gly Lys Lys Leu Gly Leu Gly Xaa Val Val Gly Leu Val 
        355                 360                 365             


Asn Lys Asp Leu Gly Lys Lys Leu Gly Ser Xaa Val Gly Leu Val Ala 
    370                 375                 380                 


Lys Asp Cys Ala Lys Lys Ile Val Ala Ser Ser Ala Met Gly Leu Val 
385                 390                 395                 400 


Asn Lys Asp Ile Gly Lys Lys Leu Met Ser Cys Pro Leu Ala Gly Leu 
                405                 410                 415     


Ile Ser Lys Asp Ala Ile Asn Leu Lys Ala Glu Ala Leu Leu Pro Xaa 
            420                 425                 430         


Gln Glu Pro Leu Lys Ala Ser Cys Ser Xaa Asn Ile Asn Asn Gln Glu 
        435                 440                 445             


Ser Gln Glu Leu Ser Glu Ser Leu Lys Asp Ser Ala Xaa Ser Lys Xaa 
    450                 455                 460                 


Phe Glu Lys Asn Val Val Arg Gln Asn Lys Glu Ser Ile Leu Glu Lys 
465                 470                 475                 480 


Phe Ser Val Arg Lys Glu Ile Ile Asn Leu Glu Lys Glu Met Phe Asn 
                485                 490                 495     


Glu Gly Xaa Cys Ile Gln Gln Asp Ser Phe Ser Ser Ser Glu Lys Gly 
            500                 505                 510         


Ser Tyr Glu Xaa Ser Lys His Glu Lys Gln Pro Pro Val Tyr Cys Xaa 
        515                 520                 525             


Ser Pro Asp Phe Lys Met Gly Gly Ala Ser Asp Val Ser Xaa Ala Lys 
    530                 535                 540                 


Ser Pro Phe Ser Ala Val Gly Glu Ser Asn Leu Pro Ser Pro Ser Pro 
545                 550                 555                 560 


Xaa Val Ser Val Asn Pro Leu Xaa Arg Ser Pro Pro Glu Xaa Ser Ser 
                565                 570                 575     


Gln Leu Ala Pro Asn Pro Leu Leu Leu Ser Ser Xaa Xaa Glu Leu Ile 
            580                 585                 590         


Glu Glu Ile Ser Glu Ser Val Gly Lys Asn Gln Phe Xaa Ser Glu Ser 
        595                 600                 605             


Xaa His Leu Asn Val Gly His Arg Ser Val Gly His Ser Ile Ser Ile 
    610                 615                 620                 


Glu Cys Lys Gly Ile Asp Lys Glu Val Asn Asp Ser Lys Xaa Xaa His 
625                 630                 635                 640 


Ile Asp Ile Pro Arg Ile Ser Ser Ser Leu Gly Lys Lys Pro Ser Leu 
                645                 650                 655     


Xaa Ser Glu Ser Ser Ile His Xaa Ile Xaa Pro Ser Val Val Asn Phe 
            660                 665                 670         


Xaa Ser Leu Phe Ser Asn Lys Pro Phe Leu Lys Leu Gly Ala Val Ser 
        675                 680                 685             


Ala Ser Asp Lys His Cys Gln Val Ala Glu Ser Leu Ser Xaa Ser Leu 
    690                 695                 700                 


Gln Ser Lys Pro Leu Lys Lys Arg Lys Gly Arg Lys Pro Arg Trp Xaa 
705                 710                 715                 720 


Lys Val Val Ala Arg Ser Xaa Cys Arg Ser Pro Lys Gly Leu Glu Leu 
                725                 730                 735     


Glu Arg Ser Glu Leu Phe Lys Asn Val Ser Cys Ser Ser Leu Ser Asn 
            740                 745                 750         


Ser Asn Ser Glu Pro Ala Lys Phe Met Lys Asn Ile Gly Pro Pro Ser 
        755                 760                 765             


Phe Val Asp His Asp Phe Leu Lys Arg Arg Leu Pro Lys Leu Ser Lys 
    770                 775                 780                 


Ser Xaa Ala Pro Ser Leu Ala Leu Leu Ala Asp Ser Glu Lys Pro Ser 
785                 790                 795                 800 


His Lys Ser Phe Ala Xaa His Lys Leu Ser Ser Ser Met Cys Val Ser 
                805                 810                 815     


Ser Asp Leu Leu Ser Asp Ile Tyr Lys Pro Lys Arg Gly Arg Pro Lys 
            820                 825                 830         


Ser Lys Glu Met Pro Gln Leu Glu Gly Pro Pro Lys Arg Xaa Leu Lys 
        835                 840                 845             


Ile Pro Ala Ser Lys Val Phe Ser Leu Gln Ser Lys Glu Glu Gln Glu 
    850                 855                 860                 


Pro Pro Ile Leu Gln Pro Glu Ile Glu Ile Pro Ser Phe Lys Gln Gly 
865                 870                 875                 880 


Leu Ser Val Ser Pro Phe Pro Lys Lys Arg Gly Arg Pro Lys Arg Gln 
                885                 890                 895     


Met Arg Ser Pro Val Lys Met Lys Pro Pro Val Leu Ser Val Ala Pro 
            900                 905                 910         


Phe Val Ala Xaa Glu Ser Pro Ser Lys Leu Glu Ser Glu Ser Asp Asn 
        915                 920                 925             


His Arg Ser Ser Ser Asp Phe Phe Glu Ser Glu Asp Gln Leu Gln Asp 
    930                 935                 940                 


Pro Asp Asp Leu Asp Asp Ser His Arg Pro Ser Val Cys Ser Met Ser 
945                 950                 955                 960 


Asp Leu Glu Met Glu Pro Asp Lys Lys Ile Xaa Lys Arg Asn Asn Gly 
                965                 970                 975     


Gln Leu Met Lys Xaa Ile Ile Arg Lys Ile Asn Lys Met Lys Xaa Leu 
            980                 985                 990         


Lys Arg Lys Lys Leu Leu Asn Gln  Ile Leu Ser Ser Ser  Val Glu Ser 
        995                 1000                 1005             


Ser Asn  Lys Gly Lys Val Gln  Ser Lys Leu His Asn  Xaa Val Ser 
    1010                 1015                 1020             


Ser Leu  Ala Ala Xaa Phe Gly  Ser Lys Leu Gly Gln  Gln Ile Asn 
    1025                 1030                 1035             


Val Ser  Lys Lys Gly Xaa Ile  Tyr Ile Gly Lys Arg  Arg Gly Arg 
    1040                 1045                 1050             


Lys Pro  Lys Xaa Val Leu Asn  Gly Ile Leu Ser Gly  Ser Pro Xaa 
    1055                 1060                 1065             


Ser Leu  Ala Val Leu Glu Gln  Xaa Ala Gln Gln Ala  Ala Gly Ser 
    1070                 1075                 1080             


Ala Leu  Gly Gln Ile Leu Pro  Pro Leu Leu Pro Ser  Ser Ala Ser 
    1085                 1090                 1095             


Ser Ser  Glu Ile Leu Pro Ser  Pro Ile Cys Ser Gln  Ser Ser Gly 
    1100                 1105                 1110             


Xaa Ser  Gly Gly Gln Ser Pro  Val Ser Ser Asp Ala  Gly Phe Val 
    1115                 1120                 1125             


Glu Pro  Ser Ser Val Pro Tyr  Leu His Leu His Ser  Arg Gln Gly 
    1130                 1135                 1140             


Ser Met  Ile Gln Xaa Leu Ala  Met Lys Lys Ala Ser  Lys Gly Arg 
    1145                 1150                 1155             


Arg Arg  Leu Ser Pro Pro Xaa  Leu Leu Pro Asn Ser  Pro Ser His 
    1160                 1165                 1170             


Leu Ser  Glu Leu Xaa Ser Leu  Lys Glu Ala Xaa Pro  Ser Pro Ile 
    1175                 1180                 1185             


Ser Glu  Ser His Ser Asp Glu  Xaa Ile Pro Ser Asp  Ser Gly Ile 
    1190                 1195                 1200             


Gly Xaa  Asp Asn Asn Ser Xaa  Ser Asp Arg Ala Glu  Lys Phe Cys 
    1205                 1210                 1215             


Gly Gln  Lys Lys Arg Arg His  Ser Phe Glu His Val  Ser Leu Ile 
    1220                 1225                 1230             


Pro Pro  Glu Xaa Ser Xaa Val  Leu Ser Ser Leu Lys  Glu Lys His 
    1235                 1240                 1245             


Lys His  Lys Cys Lys Arg Arg  Asn His Asp Tyr Leu  Ser Tyr Asp 
    1250                 1255                 1260             


Lys Met  Lys Arg Gln Lys Arg  Lys Arg Lys Lys Lys  Tyr Pro Gln 
    1265                 1270                 1275             


Leu Arg  Asn Arg Gln Asp Pro  Asp Phe Ile Ala Glu  Leu Glu Glu 
    1280                 1285                 1290             


Leu Ile  Ser Arg Leu Ser Glu  Ile Arg Ile Xaa His  Arg Ser His 
    1295                 1300                 1305             


His Phe  Ile Pro Arg Asp Leu  Leu Pro Xaa Ile Phe  Arg Ile Asn 
    1310                 1315                 1320             


Phe Asn  Ser Phe Tyr Xaa His  Pro Ser Phe Pro Leu  Asp Pro Leu 
    1325                 1330                 1335             


His Tyr  Ile Arg Lys Pro Asp  Leu Lys Lys Lys Arg  Gly Arg Pro 
    1340                 1345                 1350             


Pro Lys  Met Arg Glu Ala Met  Ala Glu Met Pro Phe  Met His Ser 
    1355                 1360                 1365             


Leu Ser  Phe Pro Leu Ser Ser  Xaa Gly Phe Tyr Pro  Ser Tyr Gly 
    1370                 1375                 1380             


Met Pro  Tyr Ser Pro Ser Pro  Leu Xaa Ala Ala Pro  Ile Gly Leu 
    1385                 1390                 1395             


Gly Tyr  Tyr Gly Arg Tyr Pro  Pro Xaa Leu Tyr Pro  Pro Pro Pro 
    1400                 1405                 1410             


Ser Pro  Ser Phe Xaa Xaa Pro  Leu Pro Pro Pro Ser  Tyr Met His 
    1415                 1420                 1425             


Ala Gly  His Leu Leu Leu Asn  Pro Ala Lys Tyr His  Lys Lys Lys 
    1430                 1435                 1440             


His Lys  Leu Leu Arg Gln Glu  Ala Phe Leu Xaa Xaa  Ser Arg Xaa 
    1445                 1450                 1455             


Pro Leu  Leu Ser Met Ser Xaa  Tyr Pro Ser Val Pro  Pro Glu Met 
    1460                 1465                 1470             


Ala Tyr  Gly Trp Met Val Glu  His Lys His Arg His  Arg His Lys 
    1475                 1480                 1485             


His Arg  Glu His Arg Ser Ser  Glu Gln Pro Gln Val  Ser Met Asp 
    1490                 1495                 1500             


Xaa Gly  Ser Ser Arg Ser Val  Leu Glu Ser Leu Lys  Arg Tyr Arg 
    1505                 1510                 1515             


Phe Gly  Lys Asp Ala Val Gly  Glu Arg Tyr Lys His  Lys Glu Lys 
    1520                 1525                 1530             


His Arg  Cys His Met Ser Cys  Pro His Leu Ser Pro  Ser Lys Ser 
    1535                 1540                 1545             


Leu Ile  Asn Arg Glu Glu Gln  Trp Val His Arg Glu  Pro Ser Glu 
    1550                 1555                 1560             


Ser Ser  Pro Leu Ala Leu Gly  Leu Gln Xaa Pro Leu  Gln Ile Asp 
    1565                 1570                 1575             


Cys Ser  Glu Ser Ser Pro Ser  Leu Ser Leu Gly Gly  Phe Xaa Pro 
    1580                 1585                 1590             


Asn Ser  Glu Pro Ala Ser Ser  Asp Glu His Xaa Asn  Leu Phe Xaa 
    1595                 1600                 1605             


Ser Ala  Ile Gly Ser Cys Arg  Val Ser Asn Pro Asn  Ser Ser Gly 
    1610                 1615                 1620             


Arg Lys  Lys Leu Xaa Asp Ser  Pro Gly Leu Phe Ser  Ala Gln Asp 
    1625                 1630                 1635             


Xaa Ser  Leu Asn Arg Leu His  Arg Lys Glu Ser Leu  Pro Ser Asn 
    1640                 1645                 1650             


Glu Arg  Ala Val Gln Xaa Leu  Ala Gly Ser Gln Pro  Xaa Ser Asp 
    1655                 1660                 1665             


Lys Pro  Ser Gln Arg Pro Ser  Glu Ser Xaa Asn Cys  Ser Pro Xaa 
    1670                 1675                 1680             


Arg Lys  Arg Ser Ser Ser Glu  Ser Xaa Ser Ser Xaa  Val Asn Gly 
    1685                 1690                 1695             


Val Pro  Ser Arg Ser Pro Arg  Leu Val Ala Ser Gly  Asp Asp Ser 
    1700                 1705                 1710             


Val Asp  Ser Leu Leu Gln Arg  Met Val Gln Asn Glu  Asp Gln Glu 
    1715                 1720                 1725             


Pro Met  Glu Lys Ser Ile Asp  Ala Val Ile Ala Xaa  Ala Ser Ala 
    1730                 1735                 1740             


Pro Pro  Ser Ser Ser Pro Gly  Arg Ser His Ser Lys  Asp Arg Xaa 
    1745                 1750                 1755             


Leu Gly  Lys Pro Asp Ser Leu  Leu Val Pro Ala Val  Xaa Ser Asp 
    1760                 1765                 1770             


Ser Cys  Asn Asn Ser Ile Ser  Leu Leu Ser Glu Lys  Leu Xaa Ser 
    1775                 1780                 1785             


Ser Cys  Ser Pro His His Ile  Lys Arg Ser Val Val  Glu Ala Met 
    1790                 1795                 1800             


Gln Arg  Gln Ala Arg Lys Met  Cys Asn Tyr Asp Lys  Ile Leu Ala 
    1805                 1810                 1815             


Xaa Lys  Lys Asn Leu Asp His  Val Asn Lys Ile Leu  Lys Ala Lys 
    1820                 1825                 1830             


Lys Leu  Gln Arg Gln Ala Arg  Xaa Gly Asn Asn Phe  Val Lys Arg 
    1835                 1840                 1845             


Arg Pro  Gly Arg Pro Arg Lys  Cys Pro Leu Gln Ala  Val Val Ser 
    1850                 1855                 1860             


Met Gln  Ala Phe Gln Ala Ala  Gln Phe Val Asn Pro  Glu Leu Asn 
    1865                 1870                 1875             


Arg Asp  Glu Glu Gly Ala Ala  Leu His Leu Ser Pro  Asp Xaa Val 
    1880                 1885                 1890             


Xaa Asp  Val Ile Glu Ala Val  Val Gln Ser Val Asn  Leu Asn Pro 
    1895                 1900                 1905             


Glu His  Lys Lys Gly Leu Lys  Arg Lys Gly Trp Leu  Leu Glu Glu 
    1910                 1915                 1920             


Gln Xaa  Arg Lys Lys Gln Lys  Pro Leu Pro Glu Glu  Glu Glu Gln 
    1925                 1930                 1935             


Glu Asn  Asn Lys Ser Phe Asn  Glu Ala Pro Val Glu  Ile Pro Ser 
    1940                 1945                 1950             


Pro Ser  Glu Xaa Pro Ala Lys  Pro Ser Glu Pro Glu  Ser Xaa Leu 
    1955                 1960                 1965             


Gln Pro  Val Leu Ser Leu Ile  Pro Arg Glu Lys Lys  Pro Pro Arg 
    1970                 1975                 1980             


Pro Pro  Lys Lys Lys Tyr Gln  Lys Ala Gly Leu Tyr  Ser Asp Val 
    1985                 1990                 1995             


Tyr Lys  Xaa Xaa Asp Pro Lys  Ser Arg Leu Ile Gln  Leu Lys Lys 
    2000                 2005                 2010             


Glu Lys  Leu Glu Tyr Xaa Pro  Gly Glu His Glu Tyr  Gly Leu Phe 
    2015                 2020                 2025             


Pro Ala  Pro Ile His Val Gly  Lys Tyr Leu Arg Gln  Lys Arg Ile 
    2030                 2035                 2040             


Asp Phe  Gln Leu Pro Tyr Asp  Ile Leu Trp Gln Trp  Lys His Asn 
    2045                 2050                 2055             


Gln Leu  Tyr Lys Lys Pro Asp  Val Pro Leu Tyr Lys  Lys Ile Arg 
    2060                 2065                 2070             


Ser Asn  Val Tyr Val Asp Val  Lys Pro Leu Ser Gly  Tyr Glu Ala 
    2075                 2080                 2085             


Xaa Xaa  Cys Asn Cys Lys Lys  Pro Asp Asp Asp Xaa  Arg Lys Gly 
    2090                 2095                 2100             


Cys Val  Asp Asp Cys Leu Asn  Arg Met Ile Phe Ala  Glu Cys Ser 
    2105                 2110                 2115             


Pro Asn  Xaa Cys Pro Cys Gly  Glu Gln Cys Cys Asn  Gln Arg Ile 
    2120                 2125                 2130             


Gln Arg  His Glu Trp Val Gln  Cys Leu Glu Arg Phe  Arg Ala Glu 
    2135                 2140                 2145             


Glu Lys  Gly Trp Gly Ile Arg  Xaa Lys Glu Pro Leu  Lys Ala Gly 
    2150                 2155                 2160             


Gln Phe  Ile Ile Glu Tyr Leu  Gly Glu Val Val Ser  Glu Gln Glu 
    2165                 2170                 2175             


Phe Arg  Asn Arg Met Ile Glu  Gln Tyr His Asn His  Ser Asp His 
    2180                 2185                 2190             


Tyr Cys  Leu Asn Leu Asp Ser  Gly Met Val Ile Asp  Ser Tyr Arg 
    2195                 2200                 2205             


Met Gly  Asn Glu Ala Arg Phe  Ile Asn His Ser Cys  Asp Pro Asn 
    2210                 2215                 2220             


Cys Glu  Met Gln Lys Trp Ser  Val Asn Gly Val Tyr  Arg Ile Gly 
    2225                 2230                 2235             


Leu Tyr  Ala Leu Lys Asp Met  Pro Ala Gly Xaa Glu  Leu Xaa Tyr 
    2240                 2245                 2250             


Asp Tyr  Asn Phe His Ser Phe  Asn Val Glu Lys Gln  Gln Leu Cys 
    2255                 2260                 2265             


Lys Cys  Gly Phe Glu Lys Cys  Arg Gly Ile Ile Gly  Gly Lys Ser 
    2270                 2275                 2280             


Gln Arg  Val Asn Gly Leu Xaa  Ser Ser Lys Asn Ser  Gln Pro Met 
    2285                 2290                 2295             


Ala Xaa  His Lys Lys Ser Gly  Arg Ser Lys Glu Lys  Arg Lys Ser 
    2300                 2305                 2310             


Lys His  Lys Leu Lys Lys Arg  Arg Gly His Leu Ser  Glu Glu Pro 
    2315                 2320                 2325             


Ser Glu  Asn Ile Asn Xaa Pro  Xaa Arg Leu Xaa Pro  Gln Leu Gln 
    2330                 2335                 2340             


Met Lys  Pro Met Ser Asn Arg  Glu Arg Asn Phe Val  Leu Lys His 
    2345                 2350                 2355             


His Val  Phe Leu Val Arg Asn  Trp Glu Lys Ile Arg  Gln Lys Gln 
    2360                 2365                 2370             


Glu Glu  Val Lys His Xaa Ser  Asp Asn Ile His Ser  Ala Ser Leu 
    2375                 2380                 2385             


Tyr Xaa  Arg Trp Asn Gly Ile  Cys Arg Asp Asp Gly  Asn Ile Lys 
    2390                 2395                 2400             


Ser Asp  Val Phe Met Xaa Gln  Phe Ser Ala Leu Gln  Xaa Ala Arg 
    2405                 2410                 2415             


Ser Val  Arg Xaa Arg Arg Leu  Ala Ala Ala Glu Glu  Asn Ile Glu 
    2420                 2425                 2430             


Val Ala  Arg Ala Ala Arg Leu  Ala Gln Ile Phe Lys  Glu Ile Cys 
    2435                 2440                 2445             


Asp Gly  Ile Ile Ser Tyr Lys  Asp Ser Ser Arg Gln  Ala Leu Ala 
    2450                 2455                 2460             


Ala Pro  Leu Leu Asn Leu Pro  Pro Lys Lys Lys Asn  Ala Asp Tyr 
    2465                 2470                 2475             


Tyr Glu  Lys Ile Ser Asp Pro  Leu Asp Leu Ile Xaa  Ile Glu Lys 
    2480                 2485                 2490             


Gln Ile  Leu Xaa Gly Tyr Tyr  Lys Xaa Val Glu Ala  Phe Asp Ala 
    2495                 2500                 2505             


Asp Met  Leu Lys Val Phe Arg  Asn Ala Glu Lys Tyr  Tyr Gly Arg 
    2510                 2515                 2520             


Lys Ser  Pro Val Gly Arg Asp  Val Cys Arg Leu Arg  Lys Ala Tyr 
    2525                 2530                 2535             


Tyr Asn  Ala Arg His Glu Ala  Ser Ala Gln Ile Asp  Glu Ile Val 
    2540                 2545                 2550             


Gly Glu  Xaa Ala Ser Glu Ala  Asp Ser Ser Glu Xaa  Ser Val Ser 
    2555                 2560                 2565             


Glu Lys  Glu Asn Gly His Glu  Lys Asp Asp Asp Val  Ile Arg Cys 
    2570                 2575                 2580             


Ile Cys  Gly Leu Tyr Lys Asp  Glu Gly Leu Met Ile  Gln Cys Asp 
    2585                 2590                 2595             


Lys Cys  Met Val Trp Gln His  Cys Asp Cys Met Gly  Val Asn Ser 
    2600                 2605                 2610             


Asp Val  Glu His Tyr Leu Cys  Glu Gln Cys Asp Pro  Arg Pro Val 
    2615                 2620                 2625             


Asp Arg  Glu Val Pro Met Ile  Pro Arg Pro His Tyr  Ala Gln Pro 
    2630                 2635                 2640             


Gly Cys  Val Tyr Phe Ile Cys  Leu Leu Arg Asp Asp  Leu Leu Leu 
    2645                 2650                 2655             


Arg Gln  Gly Asp Cys Val Tyr  Leu Met Arg Asp Ser  Arg Arg Xaa 
    2660                 2665                 2670             


Pro Asp  Gly His Pro Val Arg  Gln Ser Tyr Arg Leu  Leu Ser His 
    2675                 2680                 2685             


Ile Asn  Arg Asp Lys Leu Asp  Ile Phe Arg Ile Glu  Lys Leu Trp 
    2690                 2695                 2700             


Lys Asn  Glu Lys Glu Glu Arg  Phe Ala Phe Gly His  His Tyr Phe 
    2705                 2710                 2715             


Arg Pro  His Glu Xaa His His  Ser Pro Ser Arg Arg  Phe Tyr His 
    2720                 2725                 2730             


Asn Glu  Leu Phe Arg Val Pro  Leu Tyr Glu Ile Ile  Pro Leu Glu 
    2735                 2740                 2745             


Ala Val  Val Gly Xaa Cys Cys  Val Leu Asp Leu Tyr  Xaa Tyr Cys 
    2750                 2755                 2760             


Lys Gly  Arg Pro Lys Gly Val  Lys Glu Gln Asp Val  Tyr Ile Cys 
    2765                 2770                 2775             


Asp Tyr  Arg Leu Asp Lys Ser  Ala His Leu Phe Tyr  Lys Ile His 
    2780                 2785                 2790             


Arg Asn  Arg Tyr Pro Val Cys  Xaa Lys Pro Tyr Ala  Phe Asp His 
    2795                 2800                 2805             


Phe Pro  Lys Lys Leu Xaa Pro  Lys Lys Asp Phe Ser  Pro His Tyr 
    2810                 2815                 2820             


Val Pro  Asp Asn Tyr Lys Arg  Asn Gly Gly Arg Ser  Ser Trp Lys 
    2825                 2830                 2835             


Ser Glu  Arg Ser Lys Pro Pro  Leu Lys Asp Leu Gly  Gln Glu Asp 
    2840                 2845                 2850             


Asp Ala  Leu Pro Leu Ile Glu  Glu Val Leu Ala Ser  Gln Glu Gln 
    2855                 2860                 2865             


Ala Ala  Asn Glu Ile Pro Ser  Leu Glu Glu Pro Glu  Arg Glu Gly 
    2870                 2875                 2880             


Ala Xaa  Ala Asn Val Ser Glu  Gly Glu Lys Lys Xaa  Glu Glu Ser 
    2885                 2890                 2895             


Ser Gln  Glu Pro Gln Ser Xaa  Cys Xaa Pro Glu Glu  Arg Arg His 
    2900                 2905                 2910             


Asn Gln  Arg Glu Arg Leu Asn  Gln Ile Leu Leu Asn  Leu Leu Glu 
    2915                 2920                 2925             


Lys Ile  Pro Gly Lys Asn Ala  Ile Asp Val Xaa Tyr  Leu Leu Glu 
    2930                 2935                 2940             


Glu Gly  Ser Gly Arg Lys Leu  Arg Arg Arg Xaa Leu  Phe Ile Pro 
    2945                 2950                 2955             


Glu Asn  Ser Phe Arg Lys 
    2960                 


<210> 3415
<211> 2969
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1184)..(1184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1237)..(1237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1304)..(1304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1392)..(1392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1418)..(1419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1454)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1465)..(1465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1504)..(1504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1592)..(1592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1604)..(1604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1608)..(1608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1628)..(1628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1639)..(1639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1659)..(1659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1666)..(1666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1678)..(1678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1683)..(1683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1692)..(1692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1695)..(1695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1758)..(1758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1771)..(1771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1819)..(1819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1841)..(1841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1892)..(1892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1894)..(1894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1925)..(1925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1957)..(1957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1967)..(1967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2001)..(2002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2019)..(2019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2094)..(2095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2105)..(2105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2126)..(2126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2161)..(2161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2254)..(2254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2257)..(2257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2295)..(2295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2305)..(2305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2339)..(2339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2341)..(2341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2344)..(2344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2384)..(2384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2395)..(2395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2414)..(2414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2421)..(2421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2427)..(2427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2495)..(2495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2502)..(2502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2507)..(2507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2561)..(2561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2570)..(2570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2678)..(2678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2728)..(2728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2758)..(2758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2766)..(2766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2806)..(2806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2819)..(2819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2890)..(2890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2900)..(2900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2910)..(2910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2912)..(2912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2944)..(2944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2959)..(2959)
<223> Selenocysteine

<400> 3415
Met Asp Pro Arg Asn Xaa Ala Met Leu Gly Leu Gly Ser Asp Ser Glu 
1               5                   10                  15      


Gly Phe Ser Arg Lys Ser Pro Ser Ala Ile Ser Xaa Gly Xaa Leu Val 
            20                  25                  30          


Ser Lys Arg Glu Val Glu Leu Glu Lys Asn Xaa Lys Glu Glu Glu Asp 
        35                  40                  45              


Leu Arg Lys Arg Asn Arg Glu Arg Asn Ile Glu Ala Gly Lys Asp Asp 
    50                  55                  60                  


Gly Leu Xaa Asp Ala Gln Gln Gln Phe Ser Val Lys Glu Xaa Asn Phe 
65                  70                  75                  80  


Ser Glu Gly Asn Leu Lys Leu Lys Ile Gly Leu Gln Ala Lys Arg Xaa 
                85                  90                  95      


Lys Lys Pro Pro Lys Asn Leu Glu Asn Tyr Val Cys Arg Pro Ala Ile 
            100                 105                 110         


Lys Xaa Xaa Ile Lys His Pro Arg Lys Ala Leu Lys Ser Gly Lys Met 
        115                 120                 125             


Xaa Asp Glu Lys Asn Glu His Cys Pro Ser Lys Arg Asp Pro Ser Lys 
    130                 135                 140                 


Leu Tyr Lys Lys Ala Asp Asp Val Ala Ala Ile Glu Cys Gln Ser Glu 
145                 150                 155                 160 


Glu Val Ile Arg Leu His Ser Gln Gly Glu Asn Asn Pro Leu Ser Lys 
                165                 170                 175     


Lys Leu Ser Pro Val His Ser Glu Met Ala Asp Tyr Ile Asn Ala Xaa 
            180                 185                 190         


Pro Ser Xaa Leu Leu Gly Ser Arg Asp Pro Asp Leu Lys Asp Arg Ala 
        195                 200                 205             


Leu Leu Asn Gly Gly Xaa Ser Val Xaa Glu Lys Leu Ala Gln Leu Ile 
    210                 215                 220                 


Ala Xaa Cys Pro Pro Ser Lys Ser Ser Lys Xaa Lys Pro Lys Lys Leu 
225                 230                 235                 240 


Gly Xaa Gly Xaa Xaa Ala Gly Leu Val Ser Lys Asp Leu Ile Arg Lys 
                245                 250                 255     


Ala Gly Val Gly Ser Val Ala Gly Ile Ile His Lys Asp Leu Ile Lys 
            260                 265                 270         


Lys Pro Xaa Ile Ser Xaa Ala Val Gly Leu Val Xaa Lys Asp Pro Gly 
        275                 280                 285             


Lys Lys Pro Val Phe Asn Ala Ala Val Gly Leu Val Asn Lys Asp Ser 
    290                 295                 300                 


Val Lys Lys Leu Gly Xaa Gly Xaa Xaa Ala Val Phe Ile Asn Lys Asn 
305                 310                 315                 320 


Leu Gly Lys Lys Pro Gly Xaa Ile Xaa Xaa Val Gly Leu Leu Ser Lys 
                325                 330                 335     


Asp Ser Gly Lys Lys Leu Gly Ile Gly Ile Val Pro Gly Leu Val His 
            340                 345                 350         


Lys Glu Ser Gly Lys Lys Leu Gly Leu Gly Xaa Val Val Gly Leu Val 
        355                 360                 365             


Asn Lys Asp Leu Gly Lys Lys Leu Gly Ser Xaa Val Gly Leu Val Ala 
    370                 375                 380                 


Lys Asp Cys Ala Lys Lys Ile Val Ala Ser Ser Ala Met Gly Leu Val 
385                 390                 395                 400 


Asn Lys Asp Ile Gly Lys Lys Leu Met Ser Cys Pro Leu Ala Gly Leu 
                405                 410                 415     


Ile Ser Lys Asp Ala Ile Asn Leu Lys Ala Glu Ala Leu Leu Pro Xaa 
            420                 425                 430         


Gln Glu Pro Leu Lys Ala Ser Cys Ser Xaa Asn Ile Asn Asn Gln Glu 
        435                 440                 445             


Ser Gln Glu Leu Ser Glu Ser Leu Lys Asp Ser Ala Xaa Ser Lys Xaa 
    450                 455                 460                 


Phe Glu Lys Asn Val Val Arg Gln Asn Lys Glu Ser Ile Leu Glu Lys 
465                 470                 475                 480 


Phe Ser Val Arg Lys Glu Ile Ile Asn Leu Glu Lys Glu Met Phe Asn 
                485                 490                 495     


Glu Gly Xaa Cys Ile Gln Gln Asp Ser Phe Ser Ser Ser Glu Lys Gly 
            500                 505                 510         


Ser Tyr Glu Xaa Ser Lys His Glu Lys Gln Pro Pro Val Tyr Cys Xaa 
        515                 520                 525             


Ser Pro Asp Phe Lys Met Gly Gly Ala Ser Asp Val Ser Xaa Ala Lys 
    530                 535                 540                 


Ser Pro Phe Ser Ala Val Gly Glu Ser Asn Leu Pro Ser Pro Ser Pro 
545                 550                 555                 560 


Xaa Val Ser Val Asn Pro Leu Xaa Arg Ser Pro Pro Glu Xaa Ser Ser 
                565                 570                 575     


Gln Leu Ala Pro Asn Pro Leu Leu Leu Ser Ser Xaa Xaa Glu Leu Ile 
            580                 585                 590         


Glu Glu Ile Ser Glu Ser Val Gly Lys Asn Gln Phe Xaa Ser Glu Ser 
        595                 600                 605             


Xaa His Leu Asn Val Gly His Arg Ser Val Gly His Ser Ile Ser Ile 
    610                 615                 620                 


Glu Cys Lys Gly Ile Asp Lys Glu Val Asn Asp Ser Lys Xaa Xaa His 
625                 630                 635                 640 


Ile Asp Ile Pro Arg Ile Ser Ser Ser Leu Gly Lys Lys Pro Ser Leu 
                645                 650                 655     


Xaa Ser Glu Ser Ser Ile His Xaa Ile Xaa Pro Ser Val Val Asn Phe 
            660                 665                 670         


Xaa Ser Leu Phe Ser Asn Lys Pro Phe Leu Lys Leu Gly Ala Val Ser 
        675                 680                 685             


Ala Ser Asp Lys His Cys Gln Val Ala Glu Ser Leu Ser Xaa Ser Leu 
    690                 695                 700                 


Gln Ser Lys Pro Leu Lys Lys Arg Lys Gly Arg Lys Pro Arg Trp Xaa 
705                 710                 715                 720 


Lys Val Val Ala Arg Ser Xaa Cys Arg Ser Pro Lys Gly Leu Glu Leu 
                725                 730                 735     


Glu Arg Ser Glu Leu Phe Lys Asn Val Ser Cys Ser Ser Leu Ser Asn 
            740                 745                 750         


Ser Asn Ser Glu Pro Ala Lys Phe Met Lys Asn Ile Gly Pro Pro Ser 
        755                 760                 765             


Phe Val Asp His Asp Phe Leu Lys Arg Arg Leu Pro Lys Leu Ser Lys 
    770                 775                 780                 


Ser Xaa Ala Pro Ser Leu Ala Leu Leu Ala Asp Ser Glu Lys Pro Ser 
785                 790                 795                 800 


His Lys Ser Phe Ala Xaa His Lys Leu Ser Ser Ser Met Cys Val Ser 
                805                 810                 815     


Ser Asp Leu Leu Ser Asp Ile Tyr Lys Pro Lys Arg Gly Arg Pro Lys 
            820                 825                 830         


Ser Lys Glu Met Pro Gln Leu Glu Gly Pro Pro Lys Arg Xaa Leu Lys 
        835                 840                 845             


Ile Pro Ala Ser Lys Val Phe Ser Leu Gln Ser Lys Glu Glu Gln Glu 
    850                 855                 860                 


Pro Pro Ile Leu Gln Pro Glu Ile Glu Ile Pro Ser Phe Lys Gln Gly 
865                 870                 875                 880 


Leu Ser Val Ser Pro Phe Pro Lys Lys Arg Gly Arg Pro Lys Arg Gln 
                885                 890                 895     


Met Arg Ser Pro Val Lys Met Lys Pro Pro Val Leu Ser Val Ala Pro 
            900                 905                 910         


Phe Val Ala Xaa Glu Ser Pro Ser Lys Leu Glu Ser Glu Ser Asp Asn 
        915                 920                 925             


His Arg Ser Ser Ser Asp Phe Phe Glu Ser Glu Asp Gln Leu Gln Asp 
    930                 935                 940                 


Pro Asp Asp Leu Asp Asp Ser His Arg Pro Ser Val Cys Ser Met Ser 
945                 950                 955                 960 


Asp Leu Glu Met Glu Pro Asp Lys Lys Ile Xaa Lys Arg Asn Asn Gly 
                965                 970                 975     


Gln Leu Met Lys Xaa Ile Ile Arg Lys Ile Asn Lys Met Lys Xaa Leu 
            980                 985                 990         


Lys Arg Lys Lys Leu Leu Asn Gln  Ile Leu Ser Ser Ser  Val Glu Ser 
        995                 1000                 1005             


Ser Asn  Lys Gly Lys Val Gln  Ser Lys Leu His Asn  Xaa Val Ser 
    1010                 1015                 1020             


Ser Leu  Ala Ala Xaa Phe Gly  Ser Lys Leu Gly Gln  Gln Ile Asn 
    1025                 1030                 1035             


Val Ser  Lys Lys Gly Xaa Ile  Tyr Ile Gly Lys Arg  Arg Gly Arg 
    1040                 1045                 1050             


Lys Pro  Lys Xaa Val Leu Asn  Gly Ile Leu Ser Gly  Ser Pro Xaa 
    1055                 1060                 1065             


Ser Leu  Ala Val Leu Glu Gln  Xaa Ala Gln Gln Ala  Ala Gly Ser 
    1070                 1075                 1080             


Ala Leu  Gly Gln Ile Leu Pro  Pro Leu Leu Pro Ser  Ser Ala Ser 
    1085                 1090                 1095             


Ser Ser  Glu Ile Leu Pro Ser  Pro Ile Cys Ser Gln  Ser Ser Gly 
    1100                 1105                 1110             


Xaa Ser  Gly Gly Gln Ser Pro  Val Ser Ser Asp Ala  Gly Phe Val 
    1115                 1120                 1125             


Glu Pro  Ser Ser Val Pro Tyr  Leu His Leu His Ser  Arg Gln Gly 
    1130                 1135                 1140             


Ser Met  Ile Gln Xaa Leu Ala  Met Lys Lys Ala Ser  Lys Gly Arg 
    1145                 1150                 1155             


Arg Arg  Leu Ser Pro Pro Xaa  Leu Leu Pro Asn Ser  Pro Ser His 
    1160                 1165                 1170             


Leu Ser  Glu Leu Xaa Ser Leu  Lys Glu Ala Xaa Pro  Ser Pro Ile 
    1175                 1180                 1185             


Ser Glu  Ser His Ser Asp Glu  Xaa Ile Pro Ser Asp  Ser Gly Ile 
    1190                 1195                 1200             


Gly Xaa  Asp Asn Asn Ser Xaa  Ser Asp Arg Ala Glu  Lys Phe Cys 
    1205                 1210                 1215             


Gly Gln  Lys Lys Arg Arg His  Ser Phe Glu His Val  Ser Leu Ile 
    1220                 1225                 1230             


Pro Pro  Glu Xaa Ser Xaa Val  Leu Ser Ser Leu Lys  Glu Lys His 
    1235                 1240                 1245             


Lys His  Lys Cys Lys Arg Arg  Asn His Asp Tyr Leu  Ser Tyr Asp 
    1250                 1255                 1260             


Lys Met  Lys Arg Gln Lys Arg  Lys Arg Lys Lys Lys  Tyr Pro Gln 
    1265                 1270                 1275             


Leu Arg  Asn Arg Gln Asp Pro  Asp Phe Ile Ala Glu  Leu Glu Glu 
    1280                 1285                 1290             


Leu Ile  Ser Arg Leu Ser Glu  Ile Arg Ile Xaa His  Arg Ser His 
    1295                 1300                 1305             


His Phe  Ile Pro Arg Asp Leu  Leu Pro Xaa Ile Phe  Arg Ile Asn 
    1310                 1315                 1320             


Phe Asn  Ser Phe Tyr Xaa His  Pro Ser Phe Pro Leu  Asp Pro Leu 
    1325                 1330                 1335             


His Tyr  Ile Arg Lys Pro Asp  Leu Lys Lys Lys Arg  Gly Arg Pro 
    1340                 1345                 1350             


Pro Lys  Met Arg Glu Ala Met  Ala Glu Met Pro Phe  Met His Ser 
    1355                 1360                 1365             


Leu Ser  Phe Pro Leu Ser Ser  Xaa Gly Phe Tyr Pro  Ser Tyr Gly 
    1370                 1375                 1380             


Met Pro  Tyr Ser Pro Ser Pro  Leu Xaa Ala Ala Pro  Ile Gly Leu 
    1385                 1390                 1395             


Gly Tyr  Tyr Gly Arg Tyr Pro  Pro Xaa Leu Tyr Pro  Pro Pro Pro 
    1400                 1405                 1410             


Ser Pro  Ser Phe Xaa Xaa Pro  Leu Pro Pro Pro Ser  Tyr Met His 
    1415                 1420                 1425             


Ala Gly  His Leu Leu Leu Asn  Pro Ala Lys Tyr His  Lys Lys Lys 
    1430                 1435                 1440             


His Lys  Leu Leu Arg Gln Glu  Ala Phe Leu Xaa Xaa  Ser Arg Xaa 
    1445                 1450                 1455             


Pro Leu  Leu Ser Met Ser Xaa  Tyr Pro Ser Val Pro  Pro Glu Met 
    1460                 1465                 1470             


Ala Tyr  Gly Trp Met Val Glu  His Lys His Arg His  Arg His Lys 
    1475                 1480                 1485             


His Arg  Glu His Arg Ser Ser  Glu Gln Pro Gln Val  Ser Met Asp 
    1490                 1495                 1500             


Xaa Gly  Ser Ser Arg Ser Val  Leu Glu Ser Leu Lys  Arg Tyr Arg 
    1505                 1510                 1515             


Phe Gly  Lys Asp Ala Val Gly  Glu Arg Tyr Lys His  Lys Glu Lys 
    1520                 1525                 1530             


His Arg  Cys His Met Ser Cys  Pro His Leu Ser Pro  Ser Lys Ser 
    1535                 1540                 1545             


Leu Ile  Asn Arg Glu Glu Gln  Trp Val His Arg Glu  Pro Ser Glu 
    1550                 1555                 1560             


Ser Ser  Pro Leu Ala Leu Gly  Leu Gln Xaa Pro Leu  Gln Ile Asp 
    1565                 1570                 1575             


Cys Ser  Glu Ser Ser Pro Ser  Leu Ser Leu Gly Gly  Phe Xaa Pro 
    1580                 1585                 1590             


Asn Ser  Glu Pro Ala Ser Ser  Asp Glu His Xaa Asn  Leu Phe Xaa 
    1595                 1600                 1605             


Ser Ala  Ile Gly Ser Cys Arg  Val Ser Asn Pro Asn  Ser Ser Gly 
    1610                 1615                 1620             


Arg Lys  Lys Leu Xaa Asp Ser  Pro Gly Leu Phe Ser  Ala Gln Asp 
    1625                 1630                 1635             


Xaa Ser  Leu Asn Arg Leu His  Arg Lys Glu Ser Leu  Pro Ser Asn 
    1640                 1645                 1650             


Glu Arg  Ala Val Gln Xaa Leu  Ala Gly Ser Gln Pro  Xaa Ser Asp 
    1655                 1660                 1665             


Lys Pro  Ser Gln Arg Pro Ser  Glu Ser Xaa Asn Cys  Ser Pro Xaa 
    1670                 1675                 1680             


Arg Lys  Arg Ser Ser Ser Glu  Ser Xaa Ser Ser Xaa  Val Asn Gly 
    1685                 1690                 1695             


Val Pro  Ser Arg Ser Pro Arg  Leu Val Ala Ser Gly  Asp Asp Ser 
    1700                 1705                 1710             


Val Asp  Ser Leu Leu Gln Arg  Met Val Gln Asn Glu  Asp Gln Glu 
    1715                 1720                 1725             


Pro Met  Glu Lys Ser Ile Asp  Ala Val Ile Ala Xaa  Ala Ser Ala 
    1730                 1735                 1740             


Pro Pro  Ser Ser Ser Pro Gly  Arg Ser His Ser Lys  Asp Arg Xaa 
    1745                 1750                 1755             


Leu Gly  Lys Pro Asp Ser Leu  Leu Val Pro Ala Val  Xaa Ser Asp 
    1760                 1765                 1770             


Ser Cys  Asn Asn Ser Ile Ser  Leu Leu Ser Glu Lys  Leu Xaa Ser 
    1775                 1780                 1785             


Ser Cys  Ser Pro His His Ile  Lys Arg Ser Val Val  Glu Ala Met 
    1790                 1795                 1800             


Gln Arg  Gln Ala Arg Lys Met  Cys Asn Tyr Asp Lys  Ile Leu Ala 
    1805                 1810                 1815             


Xaa Lys  Lys Asn Leu Asp His  Val Asn Lys Ile Leu  Lys Ala Lys 
    1820                 1825                 1830             


Lys Leu  Gln Arg Gln Ala Arg  Xaa Gly Asn Asn Phe  Val Lys Arg 
    1835                 1840                 1845             


Arg Pro  Gly Arg Pro Arg Lys  Cys Pro Leu Gln Ala  Val Val Ser 
    1850                 1855                 1860             


Met Gln  Ala Phe Gln Ala Ala  Gln Phe Val Asn Pro  Glu Leu Asn 
    1865                 1870                 1875             


Arg Asp  Glu Glu Gly Ala Ala  Leu His Leu Ser Pro  Asp Xaa Val 
    1880                 1885                 1890             


Xaa Asp  Val Ile Glu Ala Val  Val Gln Ser Val Asn  Leu Asn Pro 
    1895                 1900                 1905             


Glu His  Lys Lys Gly Leu Lys  Arg Lys Gly Trp Leu  Leu Glu Glu 
    1910                 1915                 1920             


Gln Xaa  Arg Lys Lys Gln Lys  Pro Leu Pro Glu Glu  Glu Glu Gln 
    1925                 1930                 1935             


Glu Asn  Asn Lys Ser Phe Asn  Glu Ala Pro Val Glu  Ile Pro Ser 
    1940                 1945                 1950             


Pro Ser  Glu Xaa Pro Ala Lys  Pro Ser Glu Pro Glu  Ser Xaa Leu 
    1955                 1960                 1965             


Gln Pro  Val Leu Ser Leu Ile  Pro Arg Glu Lys Lys  Pro Pro Arg 
    1970                 1975                 1980             


Pro Pro  Lys Lys Lys Tyr Gln  Lys Ala Gly Leu Tyr  Ser Asp Val 
    1985                 1990                 1995             


Tyr Lys  Xaa Xaa Asp Pro Lys  Ser Arg Leu Ile Gln  Leu Lys Lys 
    2000                 2005                 2010             


Glu Lys  Leu Glu Tyr Xaa Pro  Gly Glu His Glu Tyr  Gly Leu Phe 
    2015                 2020                 2025             


Pro Ala  Pro Ile His Val Val  Phe Phe Val Ser Gly  Lys Tyr Leu 
    2030                 2035                 2040             


Arg Gln  Lys Arg Ile Asp Phe  Gln Leu Pro Tyr Asp  Ile Leu Trp 
    2045                 2050                 2055             


Gln Trp  Lys His Asn Gln Leu  Tyr Lys Lys Pro Asp  Val Pro Leu 
    2060                 2065                 2070             


Tyr Lys  Lys Ile Arg Ser Asn  Val Tyr Val Asp Val  Lys Pro Leu 
    2075                 2080                 2085             


Ser Gly  Tyr Glu Ala Xaa Xaa  Cys Asn Cys Lys Lys  Pro Asp Asp 
    2090                 2095                 2100             


Asp Xaa  Arg Lys Gly Cys Val  Asp Asp Cys Leu Asn  Arg Met Ile 
    2105                 2110                 2115             


Phe Ala  Glu Cys Ser Pro Asn  Xaa Cys Pro Cys Gly  Glu Gln Cys 
    2120                 2125                 2130             


Cys Asn  Gln Arg Ile Gln Arg  His Glu Trp Val Gln  Cys Leu Glu 
    2135                 2140                 2145             


Arg Phe  Arg Ala Glu Glu Lys  Gly Trp Gly Ile Arg  Xaa Lys Glu 
    2150                 2155                 2160             


Pro Leu  Lys Ala Gly Gln Phe  Ile Ile Glu Tyr Leu  Gly Glu Val 
    2165                 2170                 2175             


Val Ser  Glu Gln Glu Phe Arg  Asn Arg Met Ile Glu  Gln Tyr His 
    2180                 2185                 2190             


Asn His  Ser Asp His Tyr Cys  Leu Asn Leu Asp Ser  Gly Met Val 
    2195                 2200                 2205             


Ile Asp  Ser Tyr Arg Met Gly  Asn Glu Ala Arg Phe  Ile Asn His 
    2210                 2215                 2220             


Ser Cys  Asp Pro Asn Cys Glu  Met Gln Lys Trp Ser  Val Asn Gly 
    2225                 2230                 2235             


Val Tyr  Arg Ile Gly Leu Tyr  Ala Leu Lys Asp Met  Pro Ala Gly 
    2240                 2245                 2250             


Xaa Glu  Leu Xaa Tyr Asp Tyr  Asn Phe His Ser Phe  Asn Val Glu 
    2255                 2260                 2265             


Lys Gln  Gln Leu Cys Lys Cys  Gly Phe Glu Lys Cys  Arg Gly Ile 
    2270                 2275                 2280             


Ile Gly  Gly Lys Ser Gln Arg  Val Asn Gly Leu Xaa  Ser Ser Lys 
    2285                 2290                 2295             


Asn Ser  Gln Pro Met Ala Xaa  His Lys Lys Ser Gly  Arg Ser Lys 
    2300                 2305                 2310             


Glu Lys  Arg Lys Ser Lys His  Lys Leu Lys Lys Arg  Arg Gly His 
    2315                 2320                 2325             


Leu Ser  Glu Glu Pro Ser Glu  Asn Ile Asn Xaa Pro  Xaa Arg Leu 
    2330                 2335                 2340             


Xaa Pro  Gln Leu Gln Met Lys  Pro Met Ser Asn Arg  Glu Arg Asn 
    2345                 2350                 2355             


Phe Val  Leu Lys His His Val  Phe Leu Val Arg Asn  Trp Glu Lys 
    2360                 2365                 2370             


Ile Arg  Gln Lys Gln Glu Glu  Val Lys His Xaa Ser  Asp Asn Ile 
    2375                 2380                 2385             


His Ser  Ala Ser Leu Tyr Xaa  Arg Trp Asn Gly Ile  Cys Arg Asp 
    2390                 2395                 2400             


Asp Gly  Asn Ile Lys Ser Asp  Val Phe Met Xaa Gln  Phe Ser Ala 
    2405                 2410                 2415             


Leu Gln  Xaa Ala Arg Ser Val  Arg Xaa Arg Arg Leu  Ala Ala Ala 
    2420                 2425                 2430             


Glu Glu  Asn Ile Glu Val Ala  Arg Ala Ala Arg Leu  Ala Gln Ile 
    2435                 2440                 2445             


Phe Lys  Glu Ile Cys Asp Gly  Ile Ile Ser Tyr Lys  Asp Ser Ser 
    2450                 2455                 2460             


Arg Gln  Ala Leu Ala Ala Pro  Leu Leu Asn Leu Pro  Pro Lys Lys 
    2465                 2470                 2475             


Lys Asn  Ala Asp Tyr Tyr Glu  Lys Ile Ser Asp Pro  Leu Asp Leu 
    2480                 2485                 2490             


Ile Xaa  Ile Glu Lys Gln Ile  Leu Xaa Gly Tyr Tyr  Lys Xaa Val 
    2495                 2500                 2505             


Glu Ala  Phe Asp Ala Asp Met  Leu Lys Val Phe Arg  Asn Ala Glu 
    2510                 2515                 2520             


Lys Tyr  Tyr Gly Arg Lys Ser  Pro Val Gly Arg Asp  Val Cys Arg 
    2525                 2530                 2535             


Leu Arg  Lys Ala Tyr Tyr Asn  Ala Arg His Glu Ala  Ser Ala Gln 
    2540                 2545                 2550             


Ile Asp  Glu Ile Val Gly Glu  Xaa Ala Ser Glu Ala  Asp Ser Ser 
    2555                 2560                 2565             


Glu Xaa  Ser Val Ser Glu Lys  Glu Asn Gly His Glu  Lys Asp Asp 
    2570                 2575                 2580             


Asp Val  Ile Arg Cys Ile Cys  Gly Leu Tyr Lys Asp  Glu Gly Leu 
    2585                 2590                 2595             


Met Ile  Gln Cys Asp Lys Cys  Met Val Trp Gln His  Cys Asp Cys 
    2600                 2605                 2610             


Met Gly  Val Asn Ser Asp Val  Glu His Tyr Leu Cys  Glu Gln Cys 
    2615                 2620                 2625             


Asp Pro  Arg Pro Val Asp Arg  Glu Val Pro Met Ile  Pro Arg Pro 
    2630                 2635                 2640             


His Tyr  Ala Gln Pro Gly Cys  Val Tyr Phe Ile Cys  Leu Leu Arg 
    2645                 2650                 2655             


Asp Asp  Leu Leu Leu Arg Gln  Gly Asp Cys Val Tyr  Leu Met Arg 
    2660                 2665                 2670             


Asp Ser  Arg Arg Xaa Pro Asp  Gly His Pro Val Arg  Gln Ser Tyr 
    2675                 2680                 2685             


Arg Leu  Leu Ser His Ile Asn  Arg Asp Lys Leu Asp  Ile Phe Arg 
    2690                 2695                 2700             


Ile Glu  Lys Leu Trp Lys Asn  Glu Lys Glu Glu Arg  Phe Ala Phe 
    2705                 2710                 2715             


Gly His  His Tyr Phe Arg Pro  His Glu Xaa His His  Ser Pro Ser 
    2720                 2725                 2730             


Arg Arg  Phe Tyr His Asn Glu  Leu Phe Arg Val Pro  Leu Tyr Glu 
    2735                 2740                 2745             


Ile Ile  Pro Leu Glu Ala Val  Val Gly Xaa Cys Cys  Val Leu Asp 
    2750                 2755                 2760             


Leu Tyr  Xaa Tyr Cys Lys Gly  Arg Pro Lys Gly Val  Lys Glu Gln 
    2765                 2770                 2775             


Asp Val  Tyr Ile Cys Asp Tyr  Arg Leu Asp Lys Ser  Ala His Leu 
    2780                 2785                 2790             


Phe Tyr  Lys Ile His Arg Asn  Arg Tyr Pro Val Cys  Xaa Lys Pro 
    2795                 2800                 2805             


Tyr Ala  Phe Asp His Phe Pro  Lys Lys Leu Xaa Pro  Lys Lys Asp 
    2810                 2815                 2820             


Phe Ser  Pro His Tyr Val Pro  Asp Asn Tyr Lys Arg  Asn Gly Gly 
    2825                 2830                 2835             


Arg Ser  Ser Trp Lys Ser Glu  Arg Ser Lys Pro Pro  Leu Lys Asp 
    2840                 2845                 2850             


Leu Gly  Gln Glu Asp Asp Ala  Leu Pro Leu Ile Glu  Glu Val Leu 
    2855                 2860                 2865             


Ala Ser  Gln Glu Gln Ala Ala  Asn Glu Ile Pro Ser  Leu Glu Glu 
    2870                 2875                 2880             


Pro Glu  Arg Glu Gly Ala Xaa  Ala Asn Val Ser Glu  Gly Glu Lys 
    2885                 2890                 2895             


Lys Xaa  Glu Glu Ser Ser Gln  Glu Pro Gln Ser Xaa  Cys Xaa Pro 
    2900                 2905                 2910             


Glu Glu  Arg Arg His Asn Gln  Arg Glu Arg Leu Asn  Gln Ile Leu 
    2915                 2920                 2925             


Leu Asn  Leu Leu Glu Lys Ile  Pro Gly Lys Asn Ala  Ile Asp Val 
    2930                 2935                 2940             


Xaa Tyr  Leu Leu Glu Glu Gly  Ser Gly Arg Lys Leu  Arg Arg Arg 
    2945                 2950                 2955             


Xaa Leu  Phe Ile Pro Glu Asn  Ser Phe Arg Lys 
    2960                 2965                 


<210> 3416
<211> 177
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<400> 3416
Met Asp Pro Arg Asn Xaa Ala Met Leu Gly Leu Gly Ser Asp Ser Glu 
1               5                   10                  15      


Gly Phe Ser Arg Lys Ser Pro Ser Ala Ile Ser Xaa Gly Xaa Leu Val 
            20                  25                  30          


Ser Lys Arg Glu Val Glu Leu Glu Lys Asn Xaa Lys Glu Glu Glu Asp 
        35                  40                  45              


Leu Arg Lys Arg Asn Arg Glu Arg Asn Ile Glu Ala Gly Lys Asp Asp 
    50                  55                  60                  


Gly Leu Xaa Asp Ala Gln Gln Gln Phe Ser Val Lys Glu Xaa Asn Phe 
65                  70                  75                  80  


Ser Glu Gly Asn Leu Lys Leu Lys Ile Gly Leu Gln Ala Lys Arg Xaa 
                85                  90                  95      


Lys Lys Pro Pro Lys Asn Leu Glu Asn Tyr Val Cys Arg Pro Ala Ile 
            100                 105                 110         


Lys Xaa Xaa Ile Lys His Pro Arg Lys Ala Leu Lys Ser Gly Lys Met 
        115                 120                 125             


Xaa Asp Glu Lys Asn Glu His Cys Pro Ser Lys Arg Met Glu Ser Tyr 
    130                 135                 140                 


Ser Val Ala Gln Xaa Gly Val Gln Trp Cys Asp Leu Gly Ser Pro Gln 
145                 150                 155                 160 


Pro Pro Pro Pro Gly Phe Lys Arg Phe Ser Tyr Ser Pro Ala Ser Ala 
                165                 170                 175     


Pro 
    


<210> 3417
<211> 154
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<400> 3417
Xaa Leu Lys Val Phe Arg Asn Ala Glu Lys Tyr Tyr Gly Arg Lys Ser 
1               5                   10                  15      


Pro Val Gly Arg Asp Val Cys Arg Leu Arg Lys Ala Tyr Tyr Asn Ala 
            20                  25                  30          


Arg His Glu Ala Ser Ala Gln Ile Asp Glu Ile Val Gly Glu Xaa Ala 
        35                  40                  45              


Ser Glu Ala Asp Ser Ser Glu Xaa Ser Val Ser Glu Lys Glu Asn Gly 
    50                  55                  60                  


His Glu Lys Asp Asp Asp Val Ile Arg Cys Ile Cys Gly Leu Tyr Lys 
65                  70                  75                  80  


Asp Glu Gly Leu Met Ile Gln Cys Asp Lys Cys Met Val Trp Gln His 
                85                  90                  95      


Cys Asp Cys Met Gly Val Asn Ser Asp Val Glu His Tyr Leu Cys Glu 
            100                 105                 110         


Gln Cys Asp Pro Arg Pro Val Asp Arg Glu Tyr Asp Gln Arg Glu Asn 
        115                 120                 125             


Lys Ile Leu Arg Asn Leu Trp Lys Glu Trp His Tyr Ile Lys Leu Arg 
    130                 135                 140                 


Phe Leu Ala Gly His Gly Arg Ser Cys Leu 
145                 150                 


<210> 3418
<211> 263
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<400> 3418
Met Glu Leu Lys Ala Glu Glu Glu Glu Val Gly Gly Val Gln Pro Val 
1               5                   10                  15      


Ser Ile Gln Ala Phe Ala Ser Ser Ser Xaa Leu His Gly Leu Ala His 
            20                  25                  30          


Ile Phe Ser Tyr Glu Arg Leu Ser Leu Lys Arg Ala Leu Trp Ala Leu 
        35                  40                  45              


Cys Phe Leu Gly Ser Leu Ala Val Leu Leu Cys Val Cys Xaa Glu Arg 
    50                  55                  60                  


Val Gln Tyr Tyr Phe His Tyr His His Val Xaa Lys Leu Asp Glu Val 
65                  70                  75                  80  


Ala Ala Ser Gln Leu Xaa Phe Pro Ala Val Xaa Leu Cys Asn Leu Asn 
                85                  90                  95      


Glu Phe Arg Phe Ser Gln Val Ser Lys Asn Asp Leu Tyr His Ala Gly 
            100                 105                 110         


Glu Leu Leu Ala Leu Leu Asn Asn Arg Tyr Glu Ile Pro Asp Xaa Gln 
        115                 120                 125             


Met Ala Asp Glu Lys Gln Leu Glu Ile Leu Gln Asp Lys Ala Asn Phe 
    130                 135                 140                 


Arg Ser Phe Lys Pro Lys Pro Phe Asn Met Arg Glu Phe Tyr Asp Arg 
145                 150                 155                 160 


Ala Gly His Asp Ile Arg Asp Met Leu Leu Ser Cys His Phe Arg Gly 
                165                 170                 175     


Glu Val Cys Ser Ala Glu Asp Phe Lys Val Lys Pro Met Gln Val Ala 
            180                 185                 190         


Lys Glu Leu Arg Arg Cys Xaa Leu Pro Gly Xaa Val Phe Gln Gly Xaa 
        195                 200                 205             


Gln Arg Ala Arg Lys Gly Leu His Xaa Leu Trp Lys Val Leu His Val 
    210                 215                 220                 


Gln Leu Gly Pro Arg Trp Ala Ala Ala Ala Glu Asp His Glu Gly Trp 
225                 230                 235                 240 


Asp Gly Gln Trp Ala Gly Asn His Ala Gly His Pro Ala Gly Arg Val 
                245                 250                 255     


Pro Ala Cys Val Gly Gly Asp 
            260             


<210> 3419
<211> 528
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<400> 3419
Met Glu Leu Lys Ala Glu Glu Glu Glu Val Gly Gly Val Gln Pro Val 
1               5                   10                  15      


Ser Ile Gln Ala Phe Ala Ser Ser Ser Xaa Leu His Gly Leu Ala His 
            20                  25                  30          


Ile Phe Ser Tyr Glu Arg Leu Ser Leu Lys Arg Ala Leu Trp Ala Leu 
        35                  40                  45              


Cys Phe Leu Gly Ser Leu Ala Val Leu Leu Cys Val Cys Xaa Glu Arg 
    50                  55                  60                  


Val Gln Tyr Tyr Phe His Tyr His His Val Xaa Lys Leu Asp Glu Val 
65                  70                  75                  80  


Ala Ala Ser Gln Leu Xaa Phe Pro Ala Val Xaa Leu Cys Asn Leu Asn 
                85                  90                  95      


Glu Phe Arg Phe Ser Gln Val Ser Lys Asn Asp Leu Tyr His Ala Gly 
            100                 105                 110         


Glu Leu Leu Ala Leu Leu Asn Asn Arg Tyr Glu Ile Pro Asp Xaa Gln 
        115                 120                 125             


Met Ala Asp Glu Lys Gln Leu Glu Ile Leu Gln Asp Lys Ala Asn Phe 
    130                 135                 140                 


Arg Ser Phe Lys Pro Lys Pro Phe Asn Met Arg Glu Phe Tyr Asp Arg 
145                 150                 155                 160 


Ala Gly His Asp Ile Arg Asp Met Leu Leu Ser Cys His Phe Arg Gly 
                165                 170                 175     


Glu Val Cys Ser Ala Glu Asp Phe Lys Val Val Phe Xaa Arg Tyr Gly 
            180                 185                 190         


Lys Cys Tyr Xaa Phe Asn Ser Gly Arg Asp Gly Arg Pro Arg Leu Lys 
        195                 200                 205             


Xaa Met Lys Gly Gly Xaa Gly Asn Gly Leu Glu Ile Met Leu Asp Ile 
    210                 215                 220                 


Gln Gln Asp Glu Tyr Leu Pro Val Trp Gly Glu Xaa Asp Glu Xaa Ser 
225                 230                 235                 240 


Phe Glu Ala Gly Ile Lys Val Gln Ile His Ser Gln Asp Glu Pro Pro 
                245                 250                 255     


Phe Ile Asp Gln Leu Gly Phe Gly Val Ala Pro Gly Phe Gln Xaa Phe 
            260                 265                 270         


Val Ala Cys Gln Glu Gln Arg Leu Ile Tyr Leu Pro Pro Pro Trp Gly 
        275                 280                 285             


Xaa Cys Lys Ala Val Xaa Met Asp Ser Asp Leu Asp Phe Phe Asp Ser 
    290                 295                 300                 


Tyr Ser Ile Xaa Ala Cys Arg Ile Asp Cys Glu Xaa Arg Tyr Leu Val 
305                 310                 315                 320 


Glu Asn Cys Asn Cys Arg Met Val His Met Pro Gly Asp Ala Pro Tyr 
                325                 330                 335     


Cys Xaa Pro Glu Gln Tyr Lys Glu Cys Ala Asp Pro Ala Leu Asp Phe 
            340                 345                 350         


Leu Val Glu Lys Asp Gln Glu Tyr Cys Val Cys Glu Met Pro Cys Asn 
        355                 360                 365             


Leu Xaa Arg Tyr Gly Lys Glu Leu Ser Met Val Lys Ile Pro Ser Lys 
    370                 375                 380                 


Ala Ser Ala Lys Tyr Leu Ala Lys Lys Phe Asn Lys Ser Glu Gln Tyr 
385                 390                 395                 400 


Ile Gly Glu Asn Ile Leu Val Leu Asp Ile Phe Phe Glu Val Leu Asn 
                405                 410                 415     


Tyr Glu Xaa Ile Glu Gln Lys Lys Ala Tyr Glu Ile Ala Gly Leu Leu 
            420                 425                 430         


Gly Asp Ile Gly Gly Gln Met Gly Leu Phe Ile Gly Ala Ser Ile Leu 
        435                 440                 445             


Xaa Val Leu Glu Leu Phe Asp Tyr Ala Tyr Glu Val Ile Lys His Lys 
    450                 455                 460                 


Leu Cys Arg Arg Gly Lys Cys Gln Lys Glu Ala Lys Arg Ser Ser Ala 
465                 470                 475                 480 


Asp Lys Gly Val Ala Leu Ser Leu Asp Asp Val Lys Arg His Asn Pro 
                485                 490                 495     


Cys Glu Ser Leu Arg Gly His Pro Ala Gly Met Xaa Tyr Ala Ala Asn 
            500                 505                 510         


Ile Leu Pro His His Pro Ala Arg Gly Xaa Phe Glu Asp Phe Xaa Cys 
        515                 520                 525             


<210> 3420
<211> 574
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<400> 3420
Met Glu Leu Lys Ala Glu Glu Glu Glu Val Gly Gly Val Gln Pro Val 
1               5                   10                  15      


Ser Ile Gln Ala Phe Ala Ser Ser Ser Xaa Leu His Gly Leu Ala His 
            20                  25                  30          


Ile Phe Ser Tyr Glu Arg Leu Ser Leu Lys Arg Ala Leu Trp Ala Leu 
        35                  40                  45              


Cys Phe Leu Gly Ser Leu Ala Val Leu Leu Cys Val Cys Xaa Glu Arg 
    50                  55                  60                  


Val Gln Tyr Tyr Phe His Tyr His His Val Xaa Lys Leu Asp Glu Val 
65                  70                  75                  80  


Ala Ala Ser Gln Leu Xaa Phe Pro Ala Val Xaa Leu Cys Asn Leu Asn 
                85                  90                  95      


Glu Phe Arg Phe Ser Gln Val Ser Lys Asn Asp Leu Tyr His Ala Gly 
            100                 105                 110         


Glu Leu Leu Ala Leu Leu Asn Asn Arg Tyr Glu Ile Pro Asp Xaa Gln 
        115                 120                 125             


Met Ala Asp Glu Lys Gln Leu Glu Ile Leu Gln Asp Lys Ala Asn Phe 
    130                 135                 140                 


Arg Ser Phe Lys Pro Lys Pro Phe Asn Met Arg Glu Phe Tyr Asp Arg 
145                 150                 155                 160 


Ala Gly His Asp Ile Arg Asp Met Leu Leu Ser Cys His Phe Arg Gly 
                165                 170                 175     


Glu Val Cys Ser Ala Glu Asp Phe Lys Val Val Phe Xaa Arg Tyr Gly 
            180                 185                 190         


Lys Cys Tyr Xaa Phe Asn Ser Gly Arg Asp Gly Arg Pro Arg Leu Lys 
        195                 200                 205             


Xaa Met Lys Gly Gly Xaa Gly Asn Gly Leu Glu Ile Met Leu Asp Ile 
    210                 215                 220                 


Gln Gln Asp Glu Tyr Leu Pro Val Trp Gly Glu Xaa Asp Glu Xaa Ser 
225                 230                 235                 240 


Phe Glu Ala Gly Ile Lys Val Gln Ile His Ser Gln Asp Glu Pro Pro 
                245                 250                 255     


Phe Ile Asp Gln Leu Gly Phe Gly Val Ala Pro Gly Phe Gln Xaa Phe 
            260                 265                 270         


Val Ala Cys Gln Glu Gln Arg Leu Ile Tyr Leu Pro Pro Pro Trp Gly 
        275                 280                 285             


Xaa Cys Lys Ala Val Xaa Met Asp Ser Asp Leu Asp Phe Phe Asp Ser 
    290                 295                 300                 


Tyr Ser Ile Xaa Ala Cys Arg Ile Asp Cys Glu Xaa Arg Tyr Leu Val 
305                 310                 315                 320 


Glu Asn Cys Asn Cys Arg Met Val His Met Pro Gly Asp Ala Pro Tyr 
                325                 330                 335     


Cys Xaa Pro Glu Gln Tyr Lys Glu Cys Ala Asp Pro Ala Leu Asp Phe 
            340                 345                 350         


Leu Val Glu Lys Asp Gln Glu Tyr Cys Val Cys Glu Met Pro Cys Asn 
        355                 360                 365             


Leu Xaa Arg Tyr Gly Lys Glu Leu Ser Met Val Lys Ile Pro Ser Lys 
    370                 375                 380                 


Ala Ser Ala Lys Tyr Leu Ala Lys Lys Phe Asn Lys Ser Glu Gln Tyr 
385                 390                 395                 400 


Ile Gly Glu Asn Ile Leu Val Leu Asp Ile Phe Phe Glu Val Leu Asn 
                405                 410                 415     


Tyr Glu Xaa Ile Glu Gln Lys Lys Ala Tyr Glu Ile Ala Gly Leu Leu 
            420                 425                 430         


Gly Glu Leu Leu Met Xaa Pro Val Pro Phe Ser Cys His Gly His Gly 
        435                 440                 445             


Val Ala Pro Tyr His Pro Lys Ala Gly Cys Ser Leu Leu Ser His Glu 
    450                 455                 460                 


Gly Pro Pro Pro Gln Arg Pro Phe Pro Lys Pro Cys Cys Leu Gly Asp 
465                 470                 475                 480 


Ile Gly Gly Gln Met Gly Leu Phe Ile Gly Ala Ser Ile Leu Xaa Val 
                485                 490                 495     


Leu Glu Leu Phe Asp Tyr Ala Tyr Glu Val Ile Lys His Lys Leu Cys 
            500                 505                 510         


Arg Arg Gly Lys Cys Gln Lys Glu Ala Lys Arg Ser Ser Ala Asp Lys 
        515                 520                 525             


Gly Val Ala Leu Ser Leu Asp Asp Val Lys Arg His Asn Pro Cys Glu 
    530                 535                 540                 


Ser Leu Arg Gly His Pro Ala Gly Met Xaa Tyr Ala Ala Asn Ile Leu 
545                 550                 555                 560 


Pro His His Pro Ala Arg Gly Xaa Phe Glu Asp Phe Xaa Cys 
                565                 570                 


<210> 3421
<211> 562
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<400> 3421
Met Pro Ile Gln Ile Phe Cys Ser Met Ser Phe Ser Ser Gly Glu Glu 
1               5                   10                  15      


Ala Pro Gly Pro Leu Gly Asp Ile Trp Gly Pro His His His Gln Gln 
            20                  25                  30          


Gln Gln Asp Ile Ser Glu Ser Glu Glu Glu Glu Glu Glu Lys Glu Lys 
        35                  40                  45              


Glu Ala Val Arg Lys Glu Ala Ser Glu Gly His Ser Pro Met Asp Leu 
    50                  55                  60                  


Val Ala Phe Ala Asn Ser Cys Xaa Leu His Gly Xaa Asn His Ile Phe 
65                  70                  75                  80  


Val Glu Gly Gly Pro Gly Pro Arg Gln Val Leu Trp Ala Val Ala Phe 
                85                  90                  95      


Val Leu Ala Leu Gly Ala Phe Leu Cys Gln Val Gly Asp Arg Val Ala 
            100                 105                 110         


Tyr Tyr Leu Ser Tyr Pro His Val Xaa Leu Leu Asn Glu Val Ala Xaa 
        115                 120                 125             


Xaa Glu Leu Ala Phe Pro Ala Val Xaa Leu Cys Asn Xaa Asn Ala Val 
    130                 135                 140                 


Arg Leu Ser Gln Leu Ser Tyr Pro Asp Leu Leu Tyr Leu Ala Pro Met 
145                 150                 155                 160 


Leu Gly Leu Asp Glu Ser Asp Asp Pro Gly Val Pro Leu Ala Pro Pro 
                165                 170                 175     


Gly Pro Glu Ala Phe Ser Gly Glu Pro Phe Asn Leu His Arg Phe Tyr 
            180                 185                 190         


Asn Arg Ser Cys His Arg Leu Glu Asp Met Leu Leu Tyr Cys Ser Tyr 
        195                 200                 205             


Gln Gly Gly Pro Cys Gly Pro His Asn Phe Ser Val Val Phe Xaa Arg 
    210                 215                 220                 


Tyr Gly Lys Cys Tyr Xaa Phe Asn Ser Gly Arg Asp Gly Arg Pro Arg 
225                 230                 235                 240 


Leu Lys Xaa Met Lys Gly Gly Xaa Gly Asn Gly Leu Glu Ile Met Leu 
                245                 250                 255     


Asp Ile Gln Gln Asp Glu Tyr Leu Pro Val Trp Gly Glu Xaa Asp Glu 
            260                 265                 270         


Xaa Ser Phe Glu Ala Gly Ile Lys Val Gln Ile His Ser Gln Asp Glu 
        275                 280                 285             


Pro Pro Phe Ile Asp Gln Leu Gly Phe Gly Val Ala Pro Gly Phe Gln 
    290                 295                 300                 


Xaa Phe Val Ala Cys Gln Glu Gln Arg Leu Ile Tyr Leu Pro Pro Pro 
305                 310                 315                 320 


Trp Gly Xaa Cys Lys Ala Val Xaa Met Asp Ser Asp Leu Asp Phe Phe 
                325                 330                 335     


Asp Ser Tyr Ser Ile Xaa Ala Cys Arg Ile Asp Cys Glu Xaa Arg Tyr 
            340                 345                 350         


Leu Val Glu Asn Cys Asn Cys Arg Met Val His Met Pro Gly Asp Ala 
        355                 360                 365             


Pro Tyr Cys Xaa Pro Glu Gln Tyr Lys Glu Cys Ala Asp Pro Ala Leu 
    370                 375                 380                 


Asp Phe Leu Val Glu Lys Asp Gln Glu Tyr Cys Val Cys Glu Met Pro 
385                 390                 395                 400 


Cys Asn Leu Xaa Arg Tyr Gly Lys Glu Leu Ser Met Val Lys Ile Pro 
                405                 410                 415     


Ser Lys Ala Ser Ala Lys Tyr Leu Ala Lys Lys Phe Asn Lys Ser Glu 
            420                 425                 430         


Gln Tyr Ile Gly Glu Asn Ile Leu Val Leu Asp Ile Phe Phe Glu Val 
        435                 440                 445             


Leu Asn Tyr Glu Xaa Ile Glu Gln Lys Lys Ala Tyr Glu Ile Ala Gly 
    450                 455                 460                 


Leu Leu Gly Asp Ile Gly Gly Gln Met Gly Leu Phe Ile Gly Ala Ser 
465                 470                 475                 480 


Ile Leu Xaa Val Leu Glu Leu Phe Asp Tyr Ala Tyr Glu Val Ile Lys 
                485                 490                 495     


His Lys Leu Cys Arg Arg Gly Lys Cys Gln Lys Glu Ala Lys Arg Ser 
            500                 505                 510         


Ser Ala Asp Lys Gly Val Ala Leu Ser Leu Asp Asp Val Lys Arg His 
        515                 520                 525             


Asn Pro Cys Glu Ser Leu Arg Gly His Pro Ala Gly Met Xaa Tyr Ala 
    530                 535                 540                 


Ala Asn Ile Leu Pro His His Pro Ala Arg Gly Xaa Phe Glu Asp Phe 
545                 550                 555                 560 


Xaa Cys 
        


<210> 3422
<211> 127
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<400> 3422
Xaa Glu Asn Ile Leu Val Leu Asp Ile Phe Phe Glu Val Leu Asn Tyr 
1               5                   10                  15      


Glu Xaa Ile Glu Gln Lys Lys Ala Tyr Glu Ile Ala Gly Leu Leu Gly 
            20                  25                  30          


Asp Ile Gly Gly Gln Met Gly Leu Phe Ile Gly Ala Ser Ile Leu Xaa 
        35                  40                  45              


Val Leu Glu Leu Phe Asp Tyr Ala Tyr Glu Val Ile Lys His Lys Leu 
    50                  55                  60                  


Cys Arg Arg Gly Lys Cys Gln Lys Glu Ala Lys Arg Ser Ser Ala Asp 
65                  70                  75                  80  


Lys Gly Val Ala Leu Ser Leu Asp Asp Val Lys Arg His Asn Pro Cys 
                85                  90                  95      


Glu Ser Leu Arg Gly His Pro Ala Gly Met Xaa Tyr Ala Ala Asn Ile 
            100                 105                 110         


Leu Pro His His Pro Ala Arg Gly Xaa Phe Glu Asp Phe Xaa Cys 
        115                 120                 125         


<210> 3423
<211> 396
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<400> 3423
Xaa Ile Arg Asp Met Leu Leu Ser Cys His Phe Arg Gly Glu Val Cys 
1               5                   10                  15      


Ser Ala Glu Asp Phe Lys Val Lys Pro Met Gln Val Ala Lys Glu Leu 
            20                  25                  30          


Arg Arg Cys Xaa Leu Pro Gly Xaa Val Phe Gln Gly Xaa Gln Arg Ala 
        35                  40                  45              


Arg Lys Gly Glu Lys Gln Val Phe Xaa Arg Tyr Gly Lys Cys Tyr Xaa 
    50                  55                  60                  


Phe Asn Ser Gly Arg Asp Gly Arg Pro Arg Leu Lys Xaa Met Lys Gly 
65                  70                  75                  80  


Gly Xaa Gly Asn Gly Leu Glu Ile Met Leu Asp Ile Gln Gln Asp Glu 
                85                  90                  95      


Tyr Leu Pro Val Trp Gly Glu Xaa Asp Glu Xaa Ser Phe Glu Ala Gly 
            100                 105                 110         


Ile Lys Val Gln Ile His Ser Gln Asp Glu Pro Pro Phe Ile Asp Gln 
        115                 120                 125             


Leu Gly Phe Gly Val Ala Pro Gly Phe Gln Xaa Phe Val Ala Cys Gln 
    130                 135                 140                 


Glu Gln Arg Leu Ile Tyr Leu Pro Pro Pro Trp Gly Xaa Cys Lys Ala 
145                 150                 155                 160 


Val Xaa Met Asp Ser Asp Leu Asp Phe Phe Asp Ser Tyr Ser Ile Xaa 
                165                 170                 175     


Ala Cys Arg Ile Asp Cys Glu Xaa Arg Tyr Leu Val Glu Asn Cys Asn 
            180                 185                 190         


Cys Arg Met Val His Met Pro Gly Asp Ala Pro Tyr Cys Xaa Pro Glu 
        195                 200                 205             


Gln Tyr Lys Glu Cys Ala Asp Pro Ala Leu Asp Phe Leu Val Glu Lys 
    210                 215                 220                 


Asp Gln Glu Tyr Cys Val Cys Glu Met Pro Cys Asn Leu Xaa Arg Tyr 
225                 230                 235                 240 


Gly Lys Glu Leu Ser Met Val Lys Ile Pro Ser Lys Ala Ser Ala Lys 
                245                 250                 255     


Tyr Leu Ala Lys Lys Phe Asn Lys Ser Glu Gln Tyr Ile Gly Glu Asn 
            260                 265                 270         


Ile Leu Val Leu Asp Ile Phe Phe Glu Val Leu Asn Tyr Glu Xaa Ile 
        275                 280                 285             


Glu Gln Lys Lys Ala Tyr Glu Ile Ala Gly Leu Leu Gly Asp Ile Gly 
    290                 295                 300                 


Gly Gln Met Gly Leu Phe Ile Gly Ala Ser Ile Leu Xaa Val Leu Glu 
305                 310                 315                 320 


Leu Phe Asp Tyr Ala Tyr Glu Val Ile Lys His Lys Leu Cys Arg Arg 
                325                 330                 335     


Gly Lys Cys Gln Lys Glu Ala Lys Arg Ser Ser Ala Asp Lys Gly Val 
            340                 345                 350         


Ala Leu Ser Leu Asp Asp Val Lys Arg His Asn Pro Cys Glu Ser Leu 
        355                 360                 365             


Arg Gly His Pro Ala Gly Met Xaa Tyr Ala Ala Asn Ile Leu Pro His 
    370                 375                 380                 


His Pro Ala Arg Gly Xaa Phe Glu Asp Phe Xaa Cys 
385                 390                 395     


<210> 3424
<211> 149
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 3424
Cys Ala Ser Xaa Arg Tyr Ala Lys Glu Leu Ser Met Val Arg Ile Pro 
1               5                   10                  15      


Ser Arg Ala Ala Ala Arg Phe Leu Ala Arg Lys Leu Asn Arg Ser Glu 
            20                  25                  30          


Ala Tyr Ile Ala Glu Asn Val Leu Ala Leu Asp Ile Phe Phe Glu Ala 
        35                  40                  45              


Leu Asn Tyr Glu Xaa Val Glu Gln Lys Lys Ala Tyr Glu Met Ser Glu 
    50                  55                  60                  


Leu Leu Gly Asp Ile Gly Gly Gln Met Gly Leu Phe Ile Gly Ala Ser 
65                  70                  75                  80  


Leu Leu Xaa Ile Leu Glu Ile Leu Asp Tyr Leu Cys Glu Val Phe Arg 
                85                  90                  95      


Asp Lys Val Leu Gly Tyr Phe Trp Asn Arg Gln His Ser Gln Arg His 
            100                 105                 110         


Ser Ser Xaa Asn Leu Leu Gln Glu Gly Leu Gly Ser His Arg Xaa Gln 
        115                 120                 125             


Val Pro His Leu Ser Leu Gly Pro Ser Ser Arg Pro Ala Val Cys Val 
    130                 135                 140                 


Leu Gly Ala Pro Pro 
145                 


<210> 3425
<211> 407
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<400> 3425
Met Lys Pro Xaa Ser Gly Pro Glu Glu Ala Arg Arg Pro Ala Ser Asp 
1               5                   10                  15      


Ile Arg Val Phe Ala Ser Asn Cys Ser Met His Gly Leu Gly His Val 
            20                  25                  30          


Phe Gly Pro Gly Ser Leu Ser Leu Arg Arg Gly Met Trp Ala Ala Ala 
        35                  40                  45              


Val Val Leu Ser Val Ala Xaa Phe Leu Tyr Gln Val Ala Glu Arg Val 
    50                  55                  60                  


Arg Tyr Tyr Arg Glu Phe His His Gln Xaa Ala Leu Asp Glu Arg Glu 
65                  70                  75                  80  


Ser His Arg Leu Ile Phe Pro Ala Val Xaa Leu Cys Asn Ile Asn Pro 
                85                  90                  95      


Leu Arg Arg Ser Arg Leu Xaa Pro Asn Asp Leu His Trp Ala Gly Ser 
            100                 105                 110         


Ala Leu Leu Gly Leu Asp Pro Ala Glu His Ala Ala Phe Leu Arg Ala 
        115                 120                 125             


Leu Gly Arg Pro Pro Ala Pro Pro Gly Phe Met Pro Ser Pro Xaa Phe 
    130                 135                 140                 


Asp Met Ala Gln Leu Tyr Ala Arg Ala Gly His Ser Leu Asp Asp Met 
145                 150                 155                 160 


Leu Leu Asp Cys Arg Phe Arg Gly Gln Pro Cys Gly Pro Glu Asn Phe 
                165                 170                 175     


Xaa Xaa Ile Phe Xaa Arg Met Gly Lys Cys Tyr Xaa Phe Asn Ser Gly 
            180                 185                 190         


Ala Asp Gly Ala Glu Leu Leu Xaa Xaa Xaa Arg Gly Gly Met Gly Asn 
        195                 200                 205             


Gly Leu Asp Ile Met Leu Asp Val Gln Gln Glu Glu Tyr Leu Pro Val 
    210                 215                 220                 


Trp Arg Asp Asn Glu Glu Xaa Pro Phe Glu Val Gly Ile Arg Val Gln 
225                 230                 235                 240 


Ile His Ser Gln Glu Glu Pro Pro Ile Ile Asp Gln Leu Gly Leu Gly 
                245                 250                 255     


Val Ser Pro Gly Tyr Gln Xaa Phe Val Ser Cys Gln Gln Gln Gln Leu 
            260                 265                 270         


Ser Phe Leu Pro Pro Pro Trp Gly Asp Cys Ser Ser Ala Ser Leu Asn 
        275                 280                 285             


Pro Asn Tyr Glu Pro Glu Pro Ser Asp Pro Leu Gly Ser Pro Ser Pro 
    290                 295                 300                 


Ser Pro Ser Pro Pro Tyr Xaa Leu Met Gly Cys Arg Leu Ala Cys Glu 
305                 310                 315                 320 


Xaa Arg Tyr Val Ala Arg Lys Cys Gly Cys Arg Met Val Tyr Met Pro 
                325                 330                 335     


Gly Asp Val Pro Val Cys Ser Pro Gln Gln Tyr Lys Asn Cys Ala His 
            340                 345                 350         


Pro Ala Ile Gly Arg Xaa Cys Trp Pro Trp Xaa Ser Ser Leu Arg Pro 
        355                 360                 365             


Ser Xaa Met Arg Pro Trp Ser Arg Arg Arg Pro Met Arg Cys Gln Ser 
    370                 375                 380                 


Cys Leu Val Xaa Leu Gly Ala Arg Trp Gly Cys Ser Ser Gly Pro Ala 
385                 390                 395                 400 


Cys Ser Pro Ser Ser Arg Ser 
                405         


<210> 3426
<211> 531
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<400> 3426
Met Lys Pro Xaa Ser Gly Pro Glu Glu Ala Arg Arg Pro Ala Ser Asp 
1               5                   10                  15      


Ile Arg Val Phe Ala Ser Asn Cys Ser Met His Gly Leu Gly His Val 
            20                  25                  30          


Phe Gly Pro Gly Ser Leu Ser Leu Arg Arg Gly Met Trp Ala Ala Ala 
        35                  40                  45              


Val Val Leu Ser Val Ala Xaa Phe Leu Tyr Gln Val Ala Glu Arg Val 
    50                  55                  60                  


Arg Tyr Tyr Arg Glu Phe His His Gln Xaa Ala Leu Asp Glu Arg Glu 
65                  70                  75                  80  


Ser His Arg Leu Ile Phe Pro Ala Val Xaa Leu Cys Asn Ile Asn Pro 
                85                  90                  95      


Leu Arg Arg Ser Arg Leu Xaa Pro Asn Asp Leu His Trp Ala Gly Ser 
            100                 105                 110         


Ala Leu Leu Gly Leu Asp Pro Ala Glu His Ala Ala Phe Leu Arg Ala 
        115                 120                 125             


Leu Gly Arg Pro Pro Ala Pro Pro Gly Phe Met Pro Ser Pro Xaa Phe 
    130                 135                 140                 


Asp Met Ala Gln Leu Tyr Ala Arg Ala Gly His Ser Leu Asp Asp Met 
145                 150                 155                 160 


Leu Leu Asp Cys Arg Phe Arg Gly Gln Pro Cys Gly Pro Glu Asn Phe 
                165                 170                 175     


Xaa Xaa Ile Phe Xaa Arg Met Gly Lys Cys Tyr Xaa Phe Asn Ser Gly 
            180                 185                 190         


Ala Asp Gly Ala Glu Leu Leu Xaa Xaa Xaa Arg Gly Gly Met Gly Asn 
        195                 200                 205             


Gly Leu Asp Ile Met Leu Asp Val Gln Gln Glu Glu Tyr Leu Pro Val 
    210                 215                 220                 


Trp Arg Asp Asn Glu Glu Xaa Pro Phe Glu Val Gly Ile Arg Val Gln 
225                 230                 235                 240 


Ile His Ser Gln Glu Glu Pro Pro Ile Ile Asp Gln Leu Gly Leu Gly 
                245                 250                 255     


Val Ser Pro Gly Tyr Gln Xaa Phe Val Ser Cys Gln Gln Gln Gln Leu 
            260                 265                 270         


Ser Phe Leu Pro Pro Pro Trp Gly Asp Cys Ser Ser Ala Ser Leu Asn 
        275                 280                 285             


Pro Asn Tyr Glu Pro Glu Pro Ser Asp Pro Leu Gly Ser Pro Ser Pro 
    290                 295                 300                 


Ser Pro Ser Pro Pro Tyr Xaa Leu Met Gly Cys Arg Leu Ala Cys Glu 
305                 310                 315                 320 


Xaa Arg Tyr Val Ala Arg Lys Cys Gly Cys Arg Met Val Tyr Met Pro 
                325                 330                 335     


Gly Asp Val Pro Val Cys Ser Pro Gln Gln Tyr Lys Asn Cys Ala His 
            340                 345                 350         


Pro Ala Ile Asp Ala Met Leu Arg Lys Asp Ser Cys Ala Cys Pro Asn 
        355                 360                 365             


Pro Cys Ala Ser Xaa Arg Tyr Ala Lys Glu Leu Ser Met Val Arg Ile 
    370                 375                 380                 


Pro Ser Arg Ala Ala Ala Arg Phe Leu Ala Arg Lys Leu Asn Arg Ser 
385                 390                 395                 400 


Glu Ala Tyr Ile Ala Glu Asn Val Leu Ala Leu Asp Ile Phe Phe Glu 
                405                 410                 415     


Ala Leu Asn Tyr Glu Xaa Val Glu Gln Lys Lys Ala Tyr Glu Met Ser 
            420                 425                 430         


Glu Leu Leu Gly Asp Ile Gly Gly Gln Met Gly Leu Phe Ile Gly Ala 
        435                 440                 445             


Ser Leu Leu Xaa Ile Leu Glu Ile Leu Asp Tyr Leu Cys Glu Val Phe 
    450                 455                 460                 


Arg Asp Lys Val Leu Gly Tyr Phe Trp Asn Arg Gln His Ser Gln Arg 
465                 470                 475                 480 


His Ser Ser Xaa Asn Leu Leu Gln Glu Gly Leu Gly Ser His Arg Xaa 
                485                 490                 495     


Gln Val Pro His Leu Ser Leu Gly Pro Arg Pro Pro Xaa Pro Pro Cys 
            500                 505                 510         


Ala Val Xaa Lys Xaa Leu Ser Ala Ser His Arg Xaa Cys Tyr Leu Val 
        515                 520                 525             


Xaa Gln Leu 
    530     


<210> 3427
<211> 543
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<400> 3427
Met Lys Pro Xaa Ser Gly Pro Glu Glu Ala Arg Arg Pro Ala Ser Asp 
1               5                   10                  15      


Ile Arg Val Phe Ala Ser Asn Cys Ser Met His Gly Leu Gly His Val 
            20                  25                  30          


Phe Gly Pro Gly Ser Leu Ser Leu Arg Arg Gly Met Trp Ala Ala Ala 
        35                  40                  45              


Val Val Leu Ser Val Ala Xaa Phe Leu Tyr Gln Val Ala Glu Arg Val 
    50                  55                  60                  


Arg Tyr Tyr Arg Glu Phe His His Gln Xaa Ala Leu Asp Glu Arg Glu 
65                  70                  75                  80  


Ser His Arg Leu Ile Phe Pro Ala Val Xaa Leu Cys Asn Ile Asn Pro 
                85                  90                  95      


Leu Arg Arg Ser Arg Leu Xaa Pro Asn Asp Leu His Trp Ala Gly Ser 
            100                 105                 110         


Ala Leu Leu Gly Leu Asp Pro Ala Glu His Ala Ala Phe Leu Arg Ala 
        115                 120                 125             


Leu Gly Arg Pro Pro Ala Pro Pro Gly Phe Met Pro Ser Pro Xaa Phe 
    130                 135                 140                 


Asp Met Ala Gln Leu Tyr Ala Arg Ala Gly His Ser Leu Asp Asp Met 
145                 150                 155                 160 


Leu Leu Asp Cys Arg Phe Arg Gly Gln Pro Cys Gly Pro Glu Asn Phe 
                165                 170                 175     


Xaa Xaa Ile Phe Xaa Arg Met Gly Lys Cys Tyr Xaa Phe Asn Ser Gly 
            180                 185                 190         


Ala Asp Gly Ala Glu Leu Leu Xaa Xaa Xaa Arg Gly Gly Met Gly Asn 
        195                 200                 205             


Gly Leu Asp Ile Met Leu Asp Val Gln Gln Glu Glu Tyr Leu Pro Val 
    210                 215                 220                 


Trp Arg Asp Asn Glu Glu Xaa Pro Phe Glu Val Gly Ile Arg Val Gln 
225                 230                 235                 240 


Ile His Ser Gln Glu Glu Pro Pro Ile Ile Asp Gln Leu Gly Leu Gly 
                245                 250                 255     


Val Ser Pro Gly Tyr Gln Xaa Phe Val Ser Cys Gln Gln Gln Gln Leu 
            260                 265                 270         


Ser Phe Leu Pro Pro Pro Trp Gly Asp Cys Ser Ser Ala Ser Leu Asn 
        275                 280                 285             


Pro Asn Tyr Glu Pro Glu Pro Ser Asp Pro Leu Gly Ser Pro Ser Pro 
    290                 295                 300                 


Ser Pro Ser Pro Pro Tyr Xaa Leu Met Gly Cys Arg Leu Ala Cys Glu 
305                 310                 315                 320 


Xaa Arg Tyr Val Ala Arg Lys Cys Gly Cys Arg Met Val Tyr Met Pro 
                325                 330                 335     


Gly Asp Val Pro Val Cys Ser Pro Gln Gln Tyr Lys Asn Cys Ala His 
            340                 345                 350         


Pro Ala Ile Asp Ala Met Leu Arg Lys Asp Ser Cys Ala Cys Pro Asn 
        355                 360                 365             


Pro Cys Ala Ser Xaa Arg Tyr Ala Lys Glu Leu Ser Met Val Arg Ile 
    370                 375                 380                 


Pro Ser Arg Ala Ala Ala Arg Phe Leu Ala Arg Lys Leu Asn Arg Ser 
385                 390                 395                 400 


Glu Ala Tyr Ile Ala Glu Asn Val Leu Ala Leu Asp Ile Phe Phe Glu 
                405                 410                 415     


Ala Leu Asn Tyr Glu Xaa Val Glu Gln Lys Lys Ala Tyr Glu Met Ser 
            420                 425                 430         


Glu Leu Leu Gly Asp Ile Gly Gly Gln Met Gly Leu Phe Ile Gly Ala 
        435                 440                 445             


Ser Leu Leu Xaa Ile Leu Glu Ile Leu Asp Tyr Leu Cys Glu Val Phe 
    450                 455                 460                 


Arg Asp Lys Val Leu Gly Tyr Phe Trp Asn Arg Gln His Ser Gln Arg 
465                 470                 475                 480 


His Ser Ser Xaa Asn Leu Xaa Ser His Pro Ser Leu Cys Arg His Gln 
                485                 490                 495     


Asp Ser Leu Arg Leu Pro Pro His Leu Leu Pro Cys His Xaa Ala Leu 
            500                 505                 510         


Asp Leu Leu Ser Val Ser Ser Glu Pro Arg Pro Asp Ile Leu Asp Met 
        515                 520                 525             


Pro Ser Leu His Val Ala Phe Pro Ser Ser Pro Gln Ile Lys Ser 
    530                 535                 540             


<210> 3428
<211> 549
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<400> 3428
Met Lys Pro Xaa Ser Gly Pro Glu Glu Ala Arg Arg Pro Ala Ser Asp 
1               5                   10                  15      


Ile Arg Val Phe Ala Ser Asn Cys Ser Met His Gly Leu Gly His Val 
            20                  25                  30          


Phe Gly Pro Gly Ser Leu Ser Leu Arg Arg Gly Met Trp Ala Ala Ala 
        35                  40                  45              


Val Val Leu Ser Val Ala Xaa Phe Leu Tyr Gln Val Ala Glu Arg Val 
    50                  55                  60                  


Arg Tyr Tyr Arg Glu Phe His His Gln Xaa Ala Leu Asp Glu Arg Glu 
65                  70                  75                  80  


Ser His Arg Leu Ile Phe Pro Ala Val Xaa Leu Cys Asn Ile Asn Pro 
                85                  90                  95      


Leu Arg Arg Ser Arg Leu Xaa Pro Asn Asp Leu His Trp Ala Gly Ser 
            100                 105                 110         


Ala Leu Leu Gly Leu Asp Pro Ala Glu His Ala Ala Phe Leu Arg Ala 
        115                 120                 125             


Leu Gly Arg Pro Pro Ala Pro Pro Gly Phe Met Pro Ser Pro Xaa Phe 
    130                 135                 140                 


Asp Met Ala Gln Leu Tyr Ala Arg Ala Gly His Ser Leu Asp Asp Met 
145                 150                 155                 160 


Leu Leu Asp Cys Arg Phe Arg Gly Gln Pro Cys Gly Pro Glu Asn Phe 
                165                 170                 175     


Xaa Xaa Ile Phe Xaa Arg Met Gly Lys Cys Tyr Xaa Phe Asn Ser Gly 
            180                 185                 190         


Ala Asp Gly Ala Glu Leu Leu Xaa Xaa Xaa Arg Gly Gly Met Gly Asn 
        195                 200                 205             


Gly Leu Asp Ile Met Leu Asp Val Gln Gln Glu Glu Tyr Leu Pro Val 
    210                 215                 220                 


Trp Arg Asp Asn Glu Glu Xaa Pro Phe Glu Val Gly Ile Arg Val Gln 
225                 230                 235                 240 


Ile His Ser Gln Glu Glu Pro Pro Ile Ile Asp Gln Leu Gly Leu Gly 
                245                 250                 255     


Val Ser Pro Gly Tyr Gln Xaa Phe Val Ser Cys Gln Gln Gln Gln Leu 
            260                 265                 270         


Ser Phe Leu Pro Pro Pro Trp Gly Asp Cys Ser Ser Ala Ser Leu Asn 
        275                 280                 285             


Pro Asn Tyr Glu Pro Glu Pro Ser Asp Pro Leu Gly Ser Pro Ser Pro 
    290                 295                 300                 


Ser Pro Ser Pro Pro Tyr Xaa Leu Met Gly Cys Arg Leu Ala Cys Glu 
305                 310                 315                 320 


Xaa Arg Tyr Val Ala Arg Lys Cys Gly Cys Arg Met Val Tyr Met Pro 
                325                 330                 335     


Gly Asp Val Pro Val Cys Ser Pro Gln Gln Tyr Lys Asn Cys Ala His 
            340                 345                 350         


Pro Ala Ile Asp Ala Met Leu Arg Lys Asp Ser Cys Ala Cys Pro Asn 
        355                 360                 365             


Pro Cys Ala Ser Xaa Arg Tyr Ala Lys Glu Leu Ser Met Val Arg Ile 
    370                 375                 380                 


Pro Ser Arg Ala Ala Ala Arg Phe Leu Ala Arg Lys Leu Asn Arg Ser 
385                 390                 395                 400 


Glu Ala Tyr Ile Ala Glu Asn Val Leu Ala Leu Asp Ile Phe Phe Glu 
                405                 410                 415     


Ala Leu Asn Tyr Glu Xaa Val Glu Gln Lys Lys Ala Tyr Glu Met Ser 
            420                 425                 430         


Glu Leu Leu Gly Asp Ile Gly Gly Gln Met Gly Leu Phe Ile Gly Ala 
        435                 440                 445             


Ser Leu Leu Xaa Ile Leu Glu Ile Leu Asp Tyr Leu Cys Glu Val Phe 
    450                 455                 460                 


Arg Asp Lys Val Leu Gly Tyr Phe Trp Asn Arg Gln His Ser Gln Arg 
465                 470                 475                 480 


His Ser Ser Xaa Asn Leu Leu Gln Glu Gly Leu Gly Ser His Arg Xaa 
                485                 490                 495     


Gln Val Pro His Leu Ser Leu Gly Pro Ser Xaa Leu Leu Cys Ser Glu 
            500                 505                 510         


Asp Leu Pro Pro Leu Pro Val Pro Ser Pro Arg Leu Ser Pro Pro Pro 
        515                 520                 525             


Xaa Ala Pro Ala Xaa Leu Ser His Ser Ser Arg Pro Ala Val Cys Val 
    530                 535                 540                 


Leu Gly Ala Pro Pro 
545                 


<210> 3429
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<400> 3429
Xaa Glu Val Arg Leu Pro Asn Gly Val His Ala Arg Arg Arg Ala Ser 
1               5                   10                  15      


Val Gln Pro Pro Ala Val Gln Glu Leu Cys Pro Pro Gly His Arg Glu 
            20                  25                  30          


Asn Val Leu Ala Leu Asp Ile Phe Phe Glu Ala Leu Asn Tyr Glu Xaa 
        35                  40                  45              


Val Glu Gln Lys Lys Ala Tyr Glu Met Ser Glu Leu Leu Gly Asp Ile 
    50                  55                  60                  


Gly Gly Gln Met Gly Leu Phe Ile Gly Ala Ser Leu Leu Xaa Ile Leu 
65                  70                  75                  80  


Glu Ile Leu Asp Tyr Leu Cys Glu Val Phe Arg Asp Lys Val Leu Gly 
                85                  90                  95      


Tyr Phe Trp Asn Arg Gln His Ser Gln Arg His Ser Ser Xaa Asn Leu 
            100                 105                 110         


Leu Gln Glu Gly Leu Gly Ser His Arg Xaa Gln Val Pro His Leu Ser 
        115                 120                 125             


Leu Gly Pro Ser Ser Arg Pro Ala Val Cys Val Leu Gly Ala Pro Pro 
    130                 135                 140                 


<210> 3430
<211> 132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<400> 3430
Met Asp Val Xaa Arg Leu Leu Leu Ala Xaa Leu Leu Val Phe Leu Cys 
1               5                   10                  15      


Phe Phe Xaa Ala Asn Ser His Leu Pro Pro Glu Glu Lys Leu Arg Asp 
            20                  25                  30          


Asp Arg Ser Leu Arg Ser Asn Ser Ser Val Asn Leu Leu Asp Val Pro 
        35                  40                  45              


Ser Val Ser Ile Val Ala Leu Asn Lys Lys Ser Lys Gln Ile Gly Arg 
    50                  55                  60                  


Lys Ala Ala Glu Lys Lys Arg Ser Ser Lys Lys Glu Ala Ser Met Lys 
65                  70                  75                  80  


Lys Val Val Arg Pro Arg Xaa Pro Leu Ser Ala Pro Cys Val Ala Xaa 
                85                  90                  95      


Arg Asn Ser Cys Lys Pro Pro Ala Pro Ala Cys Cys Asp Pro Cys Ala 
            100                 105                 110         


Ser Cys Gln Cys Arg Phe Phe Arg Ser Ala Cys Ser Cys Arg Val Leu 
        115                 120                 125             


Ser Leu Asn Cys 
    130         


<210> 3431
<211> 1389
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1191)..(1191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1213)..(1213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1248)..(1248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1356)..(1356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1368)..(1369)
<223> Selenocysteine

<400> 3431
Met Ala Asn Arg Arg Val Gly Arg Gly Cys Trp Glu Val Ser Pro Xaa 
1               5                   10                  15      


Glu Arg Arg Pro Pro Ala Gly Leu Arg Gly Pro Ala Ala Glu Glu Glu 
            20                  25                  30          


Ala Ser Ser Pro Pro Val Leu Ser Leu Ser His Phe Cys Arg Ser Pro 
        35                  40                  45              


Phe Leu Cys Phe Gly Asp Val Leu Leu Gly Ala Ser Arg Xaa Leu Ser 
    50                  55                  60                  


Leu Ala Leu Asp Asn Pro Asn Glu Glu Val Ala Glu Val Lys Ile Ser 
65                  70                  75                  80  


His Phe Pro Ala Ala Asp Leu Gly Phe Ser Val Ser Gln Arg Cys Phe 
                85                  90                  95      


Val Leu Gln Pro Lys Glu Lys Ile Val Ile Ser Val Asn Trp Xaa Pro 
            100                 105                 110         


Leu Lys Glu Gly Arg Val Arg Glu Ile Met Xaa Phe Leu Val Asn Asp 
        115                 120                 125             


Val Leu Lys His Gln Ala Ile Leu Leu Gly Asn Ala Glu Glu Gln Lys 
    130                 135                 140                 


Lys Lys Lys Arg Ser Leu Trp Asp Xaa Ile Lys Lys Lys Lys Ile Ser 
145                 150                 155                 160 


Ala Ser Xaa Ser His Asn Arg Arg Val Ser Asn Ile Gln Asn Val Asn 
                165                 170                 175     


Lys Xaa Phe Ser Val Ser Gln Lys Val Asp Arg Arg Tyr Arg Gln Gln 
            180                 185                 190         


Xaa Tyr Phe Asn Lys Leu Lys Lys Ile Xaa Lys Xaa Val Gln Gln Arg 
        195                 200                 205             


Tyr Trp Ala Met Lys Glu Arg Asn Ile Gln Phe Gln Arg Tyr Asn Lys 
    210                 215                 220                 


Leu Arg His Ser Val Ile Tyr Ile Gln Ala Ile Phe Arg Gly Lys Lys 
225                 230                 235                 240 


Ala Arg Arg His Leu Lys Met Met His Ile Ala Ala Xaa Leu Ile Gln 
                245                 250                 255     


Arg Arg Phe Arg Xaa Leu Met Met Arg Arg Arg Phe Leu Ser Leu Lys 
            260                 265                 270         


Lys Xaa Ala Ile Leu Ile Gln Arg Lys Tyr Arg Ala His Leu Cys Xaa 
        275                 280                 285             


Lys His His Leu Gln Phe Leu Gln Val Gln Asn Ala Val Ile Lys Ile 
    290                 295                 300                 


Gln Ser Ser Tyr Arg Arg Trp Met Ile Arg Lys Arg Met Arg Glu Met 
305                 310                 315                 320 


His Arg Ala Ala Xaa Phe Ile Gln Ser Xaa Phe Arg Met His Arg Leu 
                325                 330                 335     


His Met Arg Tyr Gln Ala Leu Lys Gln Ala Ser Val Val Ile Gln Gln 
            340                 345                 350         


Gln Tyr Gln Ala Asn Arg Ala Ala Lys Leu Gln Arg Gln His Tyr Leu 
        355                 360                 365             


Arg Gln Arg His Ser Ala Val Ile Leu Gln Ala Ala Phe Arg Gly Met 
    370                 375                 380                 


Lys Xaa Arg Arg His Leu Lys Ser Met His Ser Ser Ala Xaa Leu Ile 
385                 390                 395                 400 


Gln Ser Arg Phe Arg Ser Leu Leu Val Arg Arg Arg Phe Ile Ser Leu 
                405                 410                 415     


Lys Lys Ala Xaa Ile Phe Val Gln Arg Lys Tyr Arg Ala Xaa Ile Cys 
            420                 425                 430         


Ala Lys His Lys Leu Tyr Gln Phe Leu His Leu Arg Lys Ala Ala Ile 
        435                 440                 445             


Xaa Ile Gln Ser Ser Tyr Arg Arg Leu Met Val Lys Lys Lys Leu Gln 
    450                 455                 460                 


Glu Met Gln Arg Ala Ala Val Leu Ile Gln Ala Xaa Phe Arg Met Tyr 
465                 470                 475                 480 


Arg Xaa Tyr Ile Xaa Phe Gln Xaa Trp Lys His Ala Ser Ile Leu Ile 
                485                 490                 495     


Gln Gln His Tyr Arg Xaa Tyr Arg Ala Ala Lys Leu Gln Arg Glu Asn 
            500                 505                 510         


Tyr Ile Arg Gln Trp His Ser Ala Val Val Ile Gln Ala Ala Tyr Lys 
        515                 520                 525             


Gly Met Lys Ala Arg Gln Leu Leu Arg Glu Lys His Lys Ala Ser Ile 
    530                 535                 540                 


Val Ile Gln Ser Xaa Tyr Arg Met Tyr Arg Gln Tyr Cys Phe Tyr Gln 
545                 550                 555                 560 


Lys Leu Gln Trp Ala Xaa Lys Ile Ile Gln Glu Lys Tyr Arg Ala Asn 
                565                 570                 575     


Lys Lys Lys Gln Lys Val Phe Gln His Asn Glu Leu Lys Lys Glu Xaa 
            580                 585                 590         


Cys Val Gln Ala Gly Phe Gln Asp Met Asn Ile Lys Lys Gln Ile Gln 
        595                 600                 605             


Glu Gln His Gln Ala Ala Ile Ile Ile Gln Lys His Cys Lys Ala Phe 
    610                 615                 620                 


Lys Ile Arg Lys His Tyr Leu His Leu Arg Ala Xaa Val Val Ser Ile 
625                 630                 635                 640 


Gln Arg Arg Tyr Arg Lys Leu Xaa Ala Val Arg Xaa Gln Ala Val Ile 
                645                 650                 655     


Cys Ile Gln Ser Tyr Tyr Arg Gly Phe Lys Val Arg Lys Asp Ile Gln 
            660                 665                 670         


Asn Met His Arg Ala Ala Xaa Leu Ile Gln Ser Phe Tyr Arg Met His 
        675                 680                 685             


Arg Ala Lys Val Asp Tyr Glu Xaa Lys Lys Xaa Ala Ile Val Val Ile 
    690                 695                 700                 


Gln Asn Tyr Tyr Arg Leu Tyr Val Arg Val Lys Xaa Glu Arg Lys Asn 
705                 710                 715                 720 


Phe Leu Ala Val Gln Lys Ser Val Arg Xaa Ile Gln Ala Ala Phe Arg 
                725                 730                 735     


Gly Met Lys Val Arg Gln Lys Leu Lys Asn Val Ser Glu Glu Lys Met 
            740                 745                 750         


Ala Ala Ile Val Asn Gln Ser Ala Leu Cys Cys Tyr Arg Ser Lys Xaa 
        755                 760                 765             


Gln Tyr Glu Ala Val Gln Ser Glu Gly Val Met Ile Gln Glu Trp Tyr 
    770                 775                 780                 


Lys Ala Ser Gly Leu Ala Cys Ser Gln Glu Ala Glu Tyr His Ser Gln 
785                 790                 795                 800 


Ser Arg Ala Ala Val Xaa Ile Gln Lys Ala Phe Cys Arg Met Val Xaa 
                805                 810                 815     


Arg Lys Leu Glu Xaa Gln Lys Cys Ala Ala Leu Arg Ile Gln Phe Phe 
            820                 825                 830         


Leu Gln Met Ala Val Tyr Arg Arg Arg Phe Val Gln Gln Lys Arg Ala 
        835                 840                 845             


Ala Ile Xaa Leu Gln His Tyr Phe Arg Xaa Trp Gln Xaa Arg Lys Gln 
    850                 855                 860                 


Phe Leu Leu Tyr Arg Lys Ala Ala Val Val Leu Gln Asn His Tyr Arg 
865                 870                 875                 880 


Ala Phe Leu Ser Ala Lys His Gln Arg Gln Val Tyr Leu Gln Ile Arg 
                885                 890                 895     


Ser Ser Val Ile Ile Ile Gln Ala Arg Ser Lys Gly Phe Ile Gln Lys 
            900                 905                 910         


Arg Lys Phe Gln Glu Ile Lys Asn Ser Xaa Ile Lys Ile Gln Ala Met 
        915                 920                 925             


Trp Arg Arg Tyr Arg Ala Lys Lys Tyr Leu Cys Lys Val Lys Ala Ala 
    930                 935                 940                 


Cys Lys Ile Gln Ala Trp Tyr Arg Cys Trp Arg Ala His Lys Glu Tyr 
945                 950                 955                 960 


Leu Ala Ile Leu Lys Ala Val Lys Ile Ile Gln Gly Cys Phe Tyr Xaa 
                965                 970                 975     


Lys Leu Glu Arg Xaa Arg Phe Leu Asn Val Arg Ala Ser Ala Ile Ile 
            980                 985                 990         


Ile Gln Arg Lys Trp Arg Ala Ile  Leu Pro Ala Lys Ile  Ala His Glu 
        995                 1000                 1005             


His Phe  Leu Met Ile Lys Arg  His Arg Ala Ala Cys  Leu Ile Gln 
    1010                 1015                 1020             


Ala His  Tyr Arg Gly Tyr Lys  Gly Arg Gln Val Phe  Leu Arg Gln 
    1025                 1030                 1035             


Lys Ser  Ala Ala Leu Ile Ile  Gln Lys Tyr Ile Arg  Ala Arg Glu 
    1040                 1045                 1050             


Ala Gly  Lys His Glu Arg Ile  Lys Tyr Ile Glu Phe  Lys Lys Ser 
    1055                 1060                 1065             


Xaa Val  Ile Leu Gln Ala Leu  Val Arg Gly Trp Leu  Val Arg Lys 
    1070                 1075                 1080             


Arg Phe  Leu Glu Gln Arg Ala  Lys Ile Arg Leu Leu  His Phe Xaa 
    1085                 1090                 1095             


Ala Ala  Ala Tyr Tyr His Leu  Asn Ala Val Arg Ile  Gln Arg Ala 
    1100                 1105                 1110             


Tyr Lys  Leu Tyr Leu Ala Val  Lys Asn Ala Asn Lys  Gln Val Asn 
    1115                 1120                 1125             


Ser Val  Ile Cys Ile Gln Arg  Trp Phe Arg Ala Arg  Leu Gln Glu 
    1130                 1135                 1140             


Lys Arg  Phe Ile Gln Lys Tyr  His Ser Ile Lys Lys  Ile Glu His 
    1145                 1150                 1155             


Glu Gly  Gln Glu Cys Leu Ser  Gln Arg Asn Arg Ala  Ala Ser Val 
    1160                 1165                 1170             


Ile Gln  Lys Ala Val Arg His  Phe Leu Leu Arg Lys  Lys Gln Glu 
    1175                 1180                 1185             


Lys Phe  Xaa Ser Gly Ile Ile  Lys Ile Gln Ala Leu  Trp Arg Gly 
    1190                 1195                 1200             


Tyr Ser  Trp Arg Lys Lys Asn  Asp Cys Xaa Lys Ile  Lys Ala Ile 
    1205                 1210                 1215             


Arg Leu  Ser Leu Gln Val Val  Asn Arg Glu Ile Arg  Glu Glu Asn 
    1220                 1225                 1230             


Lys Leu  Tyr Lys Arg Xaa Ala  Leu Ala Leu His Tyr  Leu Leu Xaa 
    1235                 1240                 1245             


Tyr Lys  His Leu Ser Ala Ile  Leu Glu Ala Leu Lys  His Leu Glu 
    1250                 1255                 1260             


Val Val  Xaa Arg Leu Ser Pro  Leu Cys Cys Glu Asn  Met Ala Gln 
    1265                 1270                 1275             


Ser Gly  Ala Ile Ser Lys Ile  Phe Val Leu Ile Arg  Ser Cys Asn 
    1280                 1285                 1290             


Arg Ser  Ile Pro Cys Met Glu  Val Ile Arg Tyr Ala  Val Gln Val 
    1295                 1300                 1305             


Leu Leu  Asn Val Ser Lys Tyr  Glu Lys Xaa Xaa Ser  Ala Val Tyr 
    1310                 1315                 1320             


Asp Val  Glu Asn Cys Ile Asp  Ile Leu Leu Glu Leu  Leu Gln Ile 
    1325                 1330                 1335             


Tyr Arg  Glu Lys Pro Gly Asn  Lys Val Ala Asp Lys  Gly Gly Ser 
    1340                 1345                 1350             


Ile Phe  Xaa Lys Xaa Cys Cys  Leu Leu Ala Ile Leu  Leu Lys Xaa 
    1355                 1360                 1365             


Xaa Asn  Arg Ala Ser Val Ser  Ile Ser Gln Leu Pro  Phe Phe Lys 
    1370                 1375                 1380             


Ile Ile  Phe Leu Trp Ser 
    1385                 


<210> 3432
<211> 1892
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1405)..(1405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1410)..(1410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1498)..(1498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1527)..(1527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1620)..(1620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1642)..(1642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1668)..(1668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1677)..(1677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1695)..(1695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1747)..(1748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1785)..(1785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1797)..(1798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1821)..(1821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1829)..(1829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1850)..(1850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1854)..(1854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1875)..(1875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1887)..(1887)
<223> Selenocysteine

<400> 3432
Met Ala Asn Arg Arg Val Gly Arg Gly Cys Trp Glu Val Ser Pro Xaa 
1               5                   10                  15      


Glu Arg Arg Pro Pro Ala Gly Leu Arg Gly Pro Ala Ala Glu Glu Glu 
            20                  25                  30          


Ala Ser Ser Pro Pro Val Leu Ser Leu Ser His Phe Cys Arg Ser Pro 
        35                  40                  45              


Phe Leu Cys Phe Gly Asp Val Leu Leu Gly Ala Ser Arg Xaa Leu Ser 
    50                  55                  60                  


Leu Ala Leu Asp Asn Pro Asn Glu Glu Val Ala Glu Val Lys Ile Ser 
65                  70                  75                  80  


His Phe Pro Ala Ala Asp Leu Gly Phe Ser Val Ser Gln Arg Cys Phe 
                85                  90                  95      


Val Leu Gln Pro Lys Glu Lys Ile Val Ile Ser Val Asn Trp Xaa Pro 
            100                 105                 110         


Leu Lys Glu Gly Arg Val Arg Glu Ile Met Xaa Phe Leu Val Asn Asp 
        115                 120                 125             


Val Leu Lys His Gln Ala Ile Leu Leu Gly Asn Ala Glu Glu Gln Lys 
    130                 135                 140                 


Lys Lys Lys Arg Ser Leu Trp Asp Xaa Ile Lys Lys Lys Lys Ile Ser 
145                 150                 155                 160 


Ala Ser Xaa Ser His Asn Arg Arg Val Ser Asn Ile Gln Asn Val Asn 
                165                 170                 175     


Lys Xaa Phe Ser Val Ser Gln Lys Val Asp Arg Val Arg Ser Pro Leu 
            180                 185                 190         


Gln Ala Cys Glu Asn Leu Ala Met Asn Glu Gly Gly Pro Pro Xaa Glu 
        195                 200                 205             


Asn Asn Ser Leu Ile Leu Glu Glu Asn Lys Ile Pro Ile Ser Pro Ile 
    210                 215                 220                 


Ser Pro Ala Phe Asn Glu Cys His Gly Ala Xaa Cys Leu Pro Leu Ser 
225                 230                 235                 240 


Val Arg Arg Ser Xaa Xaa Tyr Ser Ser Leu His Ala Ser Glu Asn Arg 
                245                 250                 255     


Glu Leu Leu Asn Val His Ser Ala Asn Val Ser Lys Val Ser Phe Asn 
            260                 265                 270         


Glu Lys Ala Val Xaa Glu Xaa Ser Phe Asn Ser Val Asn Val Asn Gly 
        275                 280                 285             


Gln Arg Gly Glu Asn Ser Lys Leu Ser Leu Xaa Pro Asn Cys Ser Ser 
    290                 295                 300                 


Xaa Leu Asn Ile Xaa Gln Ser Gln Ile His Phe Leu Ser Pro Asp Ser 
305                 310                 315                 320 


Phe Val Asn Asn Ser His Gly Ala Asn Asn Glu Leu Glu Leu Val Xaa 
                325                 330                 335     


Cys Leu Ser Ser Asp Met Phe Met Lys Asp Asn Ser Gln Pro Val His 
            340                 345                 350         


Leu Glu Ser Xaa Ile Ala His Glu Ile Tyr Gln Lys Ile Leu Ser Pro 
        355                 360                 365             


Asp Ser Phe Ile Lys Asp Asn Tyr Gly Leu Asn Gln Asp Leu Glu Ser 
    370                 375                 380                 


Glu Ser Val Asn Pro Ile Leu Ser Pro Asn Gln Phe Leu Lys Asp Asn 
385                 390                 395                 400 


Met Ala Tyr Met Cys Xaa Ser Gln Gln Xaa Cys Lys Val Pro Leu Ser 
                405                 410                 415     


Asn Glu Asn Ser Gln Val Pro Gln Ser Pro Glu Asp Trp Arg Lys Ser 
            420                 425                 430         


Glu Val Ser Pro Arg Ile Pro Glu Cys Gln Gly Ser Lys Ser Pro Lys 
        435                 440                 445             


Ala Ile Phe Glu Glu Leu Val Glu Met Lys Ser Asn Tyr Tyr Ser Phe 
    450                 455                 460                 


Ile Lys Gln Asn Asn Pro Lys Phe Ser Ala Val Gln Asp Ile Ser Ser 
465                 470                 475                 480 


His Ser His Asn Lys Gln Pro Lys Arg Arg Pro Ile Leu Ser Ala Xaa 
                485                 490                 495     


Val Xaa Lys Arg Lys Ala Xaa Cys Xaa Arg Glu Asn Gln Xaa Glu Ile 
            500                 505                 510         


Asn Lys Pro Lys Ala Lys Arg Cys Leu Asn Ser Ala Val Gly Glu His 
        515                 520                 525             


Glu Lys Val Ile Asn Asn Gln Lys Glu Lys Glu Asp Phe His Ser Tyr 
    530                 535                 540                 


Leu Pro Ile Ile Asp Pro Ile Leu Ser Lys Ser Lys Ser Tyr Lys Asn 
545                 550                 555                 560 


Glu Val Xaa Pro Ser Ser Xaa Xaa Ala Ser Val Ala Arg Lys Arg Lys 
                565                 570                 575     


Ser Asp Gly Ser Met Glu Asp Ala Asn Val Arg Val Ala Ile Xaa Glu 
            580                 585                 590         


His Xaa Glu Val Arg Glu Ile Lys Arg Ile His Phe Ser Pro Ser Glu 
        595                 600                 605             


Pro Lys Xaa Ser Ala Val Lys Lys Xaa Lys Asn Val Xaa Xaa Pro Ile 
    610                 615                 620                 


Ser Lys Arg Ile Ser Asn Arg Glu Lys Leu Asn Leu Lys Lys Lys Xaa 
625                 630                 635                 640 


Asp Leu Ser Ile Phe Arg Xaa Pro Ile Ser Lys Xaa Asn Lys Arg Xaa 
                645                 650                 655     


Lys Pro Ile Ile Ala Val Ala Gln Ser Ser Leu Xaa Phe Ile Lys Pro 
            660                 665                 670         


Leu Lys Xaa Asp Ile Pro Arg His Pro Met Pro Phe Ala Ala Lys Asn 
        675                 680                 685             


Met Phe Tyr Asp Glu Arg Trp Lys Glu Lys Gln Glu Gln Gly Phe Xaa 
    690                 695                 700                 


Trp Trp Leu Asn Phe Ile Leu Xaa Pro Asp Asp Phe Xaa Val Lys Xaa 
705                 710                 715                 720 


Asn Ile Ser Glu Val Asn Ala Ala Xaa Leu Leu Leu Gly Ile Glu Asn 
                725                 730                 735     


Gln His Lys Ile Ser Val Pro Arg Ala Pro Xaa Lys Glu Glu Met Ser 
            740                 745                 750         


Leu Arg Ala Tyr Xaa Ala Arg Cys Arg Leu Asn Arg Leu Arg Arg Ala 
        755                 760                 765             


Ala Cys Arg Leu Phe Xaa Ser Glu Lys Met Val Lys Ala Ile Lys Lys 
    770                 775                 780                 


Leu Glu Ile Glu Ile Glu Ala Arg Arg Leu Ile Val Arg Lys Asp Arg 
785                 790                 795                 800 


His Leu Trp Lys Asp Val Gly Glu Arg Gln Lys Val Leu Asn Trp Leu 
                805                 810                 815     


Leu Ser Tyr Asn Pro Leu Trp Leu Arg Ile Gly Leu Glu Xaa Xaa Tyr 
            820                 825                 830         


Gly Glu Leu Ile Ser Leu Glu Asp Asn Ser Asp Val Xaa Gly Leu Ala 
        835                 840                 845             


Met Phe Ile Leu Asn Arg Leu Leu Trp Asn Pro Asp Ile Ala Ala Glu 
    850                 855                 860                 


Tyr Arg His Pro Xaa Val Pro His Leu Tyr Arg Asp Gly His Glu Glu 
865                 870                 875                 880 


Ala Leu Ser Lys Phe Xaa Leu Lys Lys Leu Leu Leu Leu Val Cys Phe 
                885                 890                 895     


Leu Asp Tyr Ala Lys Ile Ser Arg Leu Ile Asp His Asp Pro Cys Leu 
            900                 905                 910         


Phe Cys Lys Asp Ala Glu Phe Lys Ala Ser Lys Glu Ile Leu Leu Ala 
        915                 920                 925             


Phe Ser Arg Asp Phe Leu Ser Gly Glu Gly Asp Leu Ser Arg His Leu 
    930                 935                 940                 


Gly Leu Leu Gly Leu Pro Val Asn His Val Gln Xaa Pro Phe Asp Glu 
945                 950                 955                 960 


Phe Asp Phe Ala Val Xaa Asn Leu Ala Val Asp Leu Gln Cys Gly Val 
                965                 970                 975     


Arg Leu Val Arg Xaa Met Glu Leu Leu Xaa Gln Asn Trp Asp Leu Ser 
            980                 985                 990         


Lys Lys Leu Arg Ile Pro Ala Ile  Ser Arg Leu Gln Lys  Met His Asn 
        995                 1000                 1005             


Val Asp  Ile Val Leu Gln Val  Leu Lys Ser Arg Gly  Ile Glu Leu 
    1010                 1015                 1020             


Ser Asp  Glu His Gly Asn Xaa  Ile Leu Ser Lys Asp  Ile Val Asp 
    1025                 1030                 1035             


Arg His  Arg Glu Lys Xaa Leu  Arg Leu Leu Trp Lys  Ile Ala Phe 
    1040                 1045                 1050             


Ala Phe  Gln Val Asp Ile Ser  Leu Asn Leu Asp Gln  Leu Lys Glu 
    1055                 1060                 1065             


Glu Ile  Ala Phe Leu Lys His  Xaa Lys Ser Ile Lys  Lys Xaa Ile 
    1070                 1075                 1080             


Ser Leu  Leu Ser Cys His Ser  Asp Asp Leu Ile Asn  Lys Lys Lys 
    1085                 1090                 1095             


Gly Lys  Arg Asp Ser Gly Ser  Phe Glu Gln Tyr Ser  Glu Asn Ile 
    1100                 1105                 1110             


Lys Leu  Leu Met Asp Trp Val  Asn Ala Val Cys Ala  Phe Tyr Asn 
    1115                 1120                 1125             


Lys Lys  Val Glu Asn Phe Xaa  Val Ser Phe Ser Asp  Gly Arg Val 
    1130                 1135                 1140             


Leu Cys  Tyr Leu Ile His His  Tyr His Pro Cys Tyr  Val Pro Phe 
    1145                 1150                 1155             


Asp Ala  Ile Cys Gln Arg Xaa  Xaa Gln Xaa Val Glu  Cys Xaa Gln 
    1160                 1165                 1170             


Xaa Gly  Ser Val Val Leu Asn  Ser Ser Ser Glu Ser  Asp Asp Ser 
    1175                 1180                 1185             


Ser Leu  Asp Met Ser Leu Lys  Ala Phe Asp His Glu  Asn Xaa Ser 
    1190                 1195                 1200             


Glu Leu  Tyr Lys Glu Leu Leu  Glu Asn Glu Lys Lys  Asn Phe His 
    1205                 1210                 1215             


Leu Val  Arg Ser Ala Val Arg  Asp Leu Gly Gly Ile  Pro Ala Met 
    1220                 1225                 1230             


Ile Asn  His Ser Asp Met Ser  Asn Xaa Ile Pro Asp  Glu Lys Val 
    1235                 1240                 1245             


Val Ile  Xaa Tyr Leu Ser Phe  Leu Cys Ala Arg Leu  Leu Asp Leu 
    1250                 1255                 1260             


Arg Lys  Glu Ile Arg Ala Ala  Arg Leu Ile Gln Xaa  Xaa Trp Arg 
    1265                 1270                 1275             


Lys Tyr  Lys Leu Lys Xaa Asp  Leu Lys Arg His Gln  Glu Arg Glu 
    1280                 1285                 1290             


Lys Ala  Ala Arg Ile Ile Gln  Leu Ala Val Ile Asn  Phe Leu Ala 
    1295                 1300                 1305             


Lys Gln  Arg Leu Arg Lys Arg  Val Asn Ala Ala Leu  Val Ile Gln 
    1310                 1315                 1320             


Lys Tyr  Trp Arg Arg Val Leu  Ala Gln Arg Lys Leu  Leu Met Leu 
    1325                 1330                 1335             


Lys Lys  Glu Lys Leu Glu Lys  Val Gln Asn Lys Ala  Ala Ser Leu 
    1340                 1345                 1350             


Ile Gln  Ala Met Trp Arg Arg  Tyr Arg Ala Lys Lys  Tyr Leu Cys 
    1355                 1360                 1365             


Lys Val  Lys Ala Ala Cys Lys  Ile Gln Ala Trp Tyr  Arg Cys Trp 
    1370                 1375                 1380             


Arg Ala  His Lys Glu Tyr Leu  Ala Ile Leu Lys Ala  Val Lys Ile 
    1385                 1390                 1395             


Ile Gln  Gly Cys Phe Tyr Xaa  Lys Leu Glu Arg Xaa  Arg Phe Leu 
    1400                 1405                 1410             


Asn Val  Arg Ala Ser Ala Ile  Ile Ile Gln Arg Lys  Trp Arg Ala 
    1415                 1420                 1425             


Ile Leu  Pro Ala Lys Ile Ala  His Glu His Phe Leu  Met Ile Lys 
    1430                 1435                 1440             


Arg His  Arg Ala Ala Cys Leu  Ile Gln Ala His Tyr  Arg Gly Tyr 
    1445                 1450                 1455             


Lys Gly  Arg Gln Val Phe Leu  Arg Gln Lys Ser Ala  Ala Leu Ile 
    1460                 1465                 1470             


Ile Gln  Lys Tyr Ile Arg Ala  Arg Glu Ala Gly Lys  His Glu Arg 
    1475                 1480                 1485             


Ile Lys  Tyr Ile Glu Phe Lys  Lys Ser Xaa Val Ile  Leu Gln Ala 
    1490                 1495                 1500             


Leu Val  Arg Gly Trp Leu Val  Arg Lys Arg Phe Leu  Glu Gln Arg 
    1505                 1510                 1515             


Ala Lys  Ile Arg Leu Leu His  Phe Xaa Ala Ala Ala  Tyr Tyr His 
    1520                 1525                 1530             


Leu Asn  Ala Val Arg Ile Gln  Arg Ala Tyr Lys Leu  Tyr Leu Ala 
    1535                 1540                 1545             


Val Lys  Asn Ala Asn Lys Gln  Val Asn Ser Val Ile  Cys Ile Gln 
    1550                 1555                 1560             


Arg Trp  Phe Arg Ala Arg Leu  Gln Glu Lys Arg Phe  Ile Gln Lys 
    1565                 1570                 1575             


Tyr His  Ser Ile Lys Lys Ile  Glu His Glu Gly Gln  Glu Cys Leu 
    1580                 1585                 1590             


Ser Gln  Arg Asn Arg Ala Ala  Ser Val Ile Gln Lys  Ala Val Arg 
    1595                 1600                 1605             


His Phe  Leu Leu Arg Lys Lys  Gln Glu Lys Phe Xaa  Ser Gly Ile 
    1610                 1615                 1620             


Ile Lys  Ile Gln Ala Leu Trp  Arg Gly Tyr Ser Trp  Arg Lys Lys 
    1625                 1630                 1635             


Asn Asp  Cys Xaa Lys Ile Lys  Ala Ile Arg Leu Ser  Leu Gln Val 
    1640                 1645                 1650             


Val Asn  Arg Glu Ile Arg Glu  Glu Asn Lys Leu Tyr  Lys Arg Xaa 
    1655                 1660                 1665             


Ala Leu  Ala Leu His Tyr Leu  Leu Xaa Tyr Lys His  Leu Ser Ala 
    1670                 1675                 1680             


Ile Leu  Glu Ala Leu Lys His  Leu Glu Val Val Xaa  Arg Leu Ser 
    1685                 1690                 1695             


Pro Leu  Cys Cys Glu Asn Met  Ala Gln Ser Gly Ala  Ile Ser Lys 
    1700                 1705                 1710             


Ile Phe  Val Leu Ile Arg Ser  Cys Asn Arg Ser Ile  Pro Cys Met 
    1715                 1720                 1725             


Glu Val  Ile Arg Tyr Ala Val  Gln Val Leu Leu Asn  Val Ser Lys 
    1730                 1735                 1740             


Tyr Glu  Lys Xaa Xaa Ser Ala  Val Tyr Asp Val Glu  Asn Cys Ile 
    1745                 1750                 1755             


Asp Ile  Leu Leu Glu Leu Leu  Gln Ile Tyr Arg Glu  Lys Pro Gly 
    1760                 1765                 1770             


Asn Lys  Val Ala Asp Lys Gly  Gly Ser Ile Phe Xaa  Lys Xaa Cys 
    1775                 1780                 1785             


Cys Leu  Leu Ala Ile Leu Leu  Lys Xaa Xaa Asn Arg  Ala Ser Asp 
    1790                 1795                 1800             


Val Arg  Ser Arg Ser Lys Val  Val Asp Arg Ile Tyr  Ser Leu Tyr 
    1805                 1810                 1815             


Lys Leu  Xaa Ala His Lys His  Lys Met Asn Xaa Glu  Arg Ile Leu 
    1820                 1825                 1830             


Tyr Lys  Gln Lys Lys Asn Ser  Ser Ile Ser Ile Pro  Phe Ile Pro 
    1835                 1840                 1845             


Glu Xaa  Pro Val Arg Xaa Arg  Ile Val Ser Arg Leu  Lys Pro Asp 
    1850                 1855                 1860             


Trp Val  Leu Arg Arg Asp Asn  Met Glu Glu Ile Xaa  Asn Pro Leu 
    1865                 1870                 1875             


Gln Ala  Ile Gln Met Val Met  Asp Xaa Leu Gly Ile  Pro Tyr 
    1880                 1885                 1890         


<210> 3433
<211> 3477
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1363)..(1363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1388)..(1388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1397)..(1397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1399)..(1399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1424)..(1424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1516)..(1516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1532)..(1532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1585)..(1585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1614)..(1614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1632)..(1632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1682)..(1682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1688)..(1688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1694)..(1694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1806)..(1806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1863)..(1863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1867)..(1867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1869)..(1869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1874)..(1874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1922)..(1922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1935)..(1935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1962)..(1962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2020)..(2020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2026)..(2026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2049)..(2049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2059)..(2059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2065)..(2065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2083)..(2083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2096)..(2096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2121)..(2121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2138)..(2138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2165)..(2165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2185)..(2185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2191)..(2191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2194)..(2194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2207)..(2207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2216)..(2216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2218)..(2218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2267)..(2267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2275)..(2275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2288)..(2288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2302)..(2302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2339)..(2339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2344)..(2344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2400)..(2400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2412)..(2412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2434)..(2434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2444)..(2444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2463)..(2463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2490)..(2490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2496)..(2496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2499)..(2499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2502)..(2502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2516)..(2516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2563)..(2563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2580)..(2580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2606)..(2606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2650)..(2650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2662)..(2662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2666)..(2666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2693)..(2693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2710)..(2710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2713)..(2713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2730)..(2730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2744)..(2744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2782)..(2782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2820)..(2820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2830)..(2830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2835)..(2835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2865)..(2865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2872)..(2872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2875)..(2875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2936)..(2936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2990)..(2990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2995)..(2995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3083)..(3083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3112)..(3112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3205)..(3205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3227)..(3227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3253)..(3253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3262)..(3262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3280)..(3280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3332)..(3333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3370)..(3370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3372)..(3372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3382)..(3383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3406)..(3406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3414)..(3414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3435)..(3435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3439)..(3439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3460)..(3460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3472)..(3472)
<223> Selenocysteine

<400> 3433
Met Ala Asn Arg Arg Val Gly Arg Gly Cys Trp Glu Val Ser Pro Xaa 
1               5                   10                  15      


Glu Arg Arg Pro Pro Ala Gly Leu Arg Gly Pro Ala Ala Glu Glu Glu 
            20                  25                  30          


Ala Ser Ser Pro Pro Val Leu Ser Leu Ser His Phe Cys Arg Ser Pro 
        35                  40                  45              


Phe Leu Cys Phe Gly Asp Val Leu Leu Gly Ala Ser Arg Xaa Leu Ser 
    50                  55                  60                  


Leu Ala Leu Asp Asn Pro Asn Glu Glu Val Ala Glu Val Lys Ile Ser 
65                  70                  75                  80  


His Phe Pro Ala Ala Asp Leu Gly Phe Ser Val Ser Gln Arg Cys Phe 
                85                  90                  95      


Val Leu Gln Pro Lys Glu Lys Ile Val Ile Ser Val Asn Trp Xaa Pro 
            100                 105                 110         


Leu Lys Glu Gly Arg Val Arg Glu Ile Met Xaa Phe Leu Val Asn Asp 
        115                 120                 125             


Val Leu Lys His Gln Ala Ile Leu Leu Gly Asn Ala Glu Glu Gln Lys 
    130                 135                 140                 


Lys Lys Lys Arg Ser Leu Trp Asp Xaa Ile Lys Lys Lys Lys Ile Ser 
145                 150                 155                 160 


Ala Ser Xaa Ser His Asn Arg Arg Val Ser Asn Ile Gln Asn Val Asn 
                165                 170                 175     


Lys Xaa Phe Ser Val Ser Gln Lys Val Asp Arg Val Arg Ser Pro Leu 
            180                 185                 190         


Gln Ala Cys Glu Asn Leu Ala Met Asn Glu Gly Gly Pro Pro Xaa Glu 
        195                 200                 205             


Asn Asn Ser Leu Ile Leu Glu Glu Asn Lys Ile Pro Ile Ser Pro Ile 
    210                 215                 220                 


Ser Pro Ala Phe Asn Glu Cys His Gly Ala Xaa Cys Leu Pro Leu Ser 
225                 230                 235                 240 


Val Arg Arg Ser Xaa Xaa Tyr Ser Ser Leu His Ala Ser Glu Asn Arg 
                245                 250                 255     


Glu Leu Leu Asn Val His Ser Ala Asn Val Ser Lys Val Ser Phe Asn 
            260                 265                 270         


Glu Lys Ala Val Xaa Glu Xaa Ser Phe Asn Ser Val Asn Val Asn Gly 
        275                 280                 285             


Gln Arg Gly Glu Asn Ser Lys Leu Ser Leu Xaa Pro Asn Cys Ser Ser 
    290                 295                 300                 


Xaa Leu Asn Ile Xaa Gln Ser Gln Ile His Phe Leu Ser Pro Asp Ser 
305                 310                 315                 320 


Phe Val Asn Asn Ser His Gly Ala Asn Asn Glu Leu Glu Leu Val Xaa 
                325                 330                 335     


Cys Leu Ser Ser Asp Met Phe Met Lys Asp Asn Ser Gln Pro Val His 
            340                 345                 350         


Leu Glu Ser Xaa Ile Ala His Glu Ile Tyr Gln Lys Ile Leu Ser Pro 
        355                 360                 365             


Asp Ser Phe Ile Lys Asp Asn Tyr Gly Leu Asn Gln Asp Leu Glu Ser 
    370                 375                 380                 


Glu Ser Val Asn Pro Ile Leu Ser Pro Asn Gln Phe Leu Lys Asp Asn 
385                 390                 395                 400 


Met Ala Tyr Met Cys Xaa Ser Gln Gln Xaa Cys Lys Val Pro Leu Ser 
                405                 410                 415     


Asn Glu Asn Ser Gln Val Pro Gln Ser Pro Glu Asp Trp Arg Lys Ser 
            420                 425                 430         


Glu Val Ser Pro Arg Ile Pro Glu Cys Gln Gly Ser Lys Ser Pro Lys 
        435                 440                 445             


Ala Ile Phe Glu Glu Leu Val Glu Met Lys Ser Asn Tyr Tyr Ser Phe 
    450                 455                 460                 


Ile Lys Gln Asn Asn Pro Lys Phe Ser Ala Val Gln Asp Ile Ser Ser 
465                 470                 475                 480 


His Ser His Asn Lys Gln Pro Lys Arg Arg Pro Ile Leu Ser Ala Xaa 
                485                 490                 495     


Val Xaa Lys Arg Lys Ala Xaa Cys Xaa Arg Glu Asn Gln Xaa Glu Ile 
            500                 505                 510         


Asn Lys Pro Lys Ala Lys Arg Cys Leu Asn Ser Ala Val Gly Glu His 
        515                 520                 525             


Glu Lys Val Ile Asn Asn Gln Lys Glu Lys Glu Asp Phe His Ser Tyr 
    530                 535                 540                 


Leu Pro Ile Ile Asp Pro Ile Leu Ser Lys Ser Lys Ser Tyr Lys Asn 
545                 550                 555                 560 


Glu Val Xaa Pro Ser Ser Xaa Xaa Ala Ser Val Ala Arg Lys Arg Lys 
                565                 570                 575     


Ser Asp Gly Ser Met Glu Asp Ala Asn Val Arg Val Ala Ile Xaa Glu 
            580                 585                 590         


His Xaa Glu Val Arg Glu Ile Lys Arg Ile His Phe Ser Pro Ser Glu 
        595                 600                 605             


Pro Lys Xaa Ser Ala Val Lys Lys Xaa Lys Asn Val Xaa Xaa Pro Ile 
    610                 615                 620                 


Ser Lys Arg Ile Ser Asn Arg Glu Lys Leu Asn Leu Lys Lys Lys Xaa 
625                 630                 635                 640 


Asp Leu Ser Ile Phe Arg Xaa Pro Ile Ser Lys Xaa Asn Lys Arg Xaa 
                645                 650                 655     


Lys Pro Ile Ile Ala Val Ala Gln Ser Ser Leu Xaa Phe Ile Lys Pro 
            660                 665                 670         


Leu Lys Xaa Asp Ile Pro Arg His Pro Met Pro Phe Ala Ala Lys Asn 
        675                 680                 685             


Met Phe Tyr Asp Glu Arg Trp Lys Glu Lys Gln Glu Gln Gly Phe Xaa 
    690                 695                 700                 


Trp Trp Leu Asn Phe Ile Leu Xaa Pro Asp Asp Phe Xaa Val Lys Xaa 
705                 710                 715                 720 


Asn Ile Ser Glu Val Asn Ala Ala Xaa Leu Leu Leu Gly Ile Glu Asn 
                725                 730                 735     


Gln His Lys Ile Ser Val Pro Arg Ala Pro Xaa Lys Glu Glu Met Ser 
            740                 745                 750         


Leu Arg Ala Tyr Xaa Ala Arg Cys Arg Leu Asn Arg Leu Arg Arg Ala 
        755                 760                 765             


Ala Cys Arg Leu Phe Xaa Ser Glu Lys Met Val Lys Ala Ile Lys Lys 
    770                 775                 780                 


Leu Glu Ile Glu Ile Glu Ala Arg Arg Leu Ile Val Arg Lys Asp Arg 
785                 790                 795                 800 


His Leu Trp Lys Asp Val Gly Glu Arg Gln Lys Val Leu Asn Trp Leu 
                805                 810                 815     


Leu Ser Tyr Asn Pro Leu Trp Leu Arg Ile Gly Leu Glu Xaa Xaa Tyr 
            820                 825                 830         


Gly Glu Leu Ile Ser Leu Glu Asp Asn Ser Asp Val Xaa Gly Leu Ala 
        835                 840                 845             


Met Phe Ile Leu Asn Arg Leu Leu Trp Asn Pro Asp Ile Ala Ala Glu 
    850                 855                 860                 


Tyr Arg His Pro Xaa Val Pro His Leu Tyr Arg Asp Gly His Glu Glu 
865                 870                 875                 880 


Ala Leu Ser Lys Phe Xaa Leu Lys Lys Leu Leu Leu Leu Val Cys Phe 
                885                 890                 895     


Leu Asp Tyr Ala Lys Ile Ser Arg Leu Ile Asp His Asp Pro Cys Leu 
            900                 905                 910         


Phe Cys Lys Asp Ala Glu Phe Lys Ala Ser Lys Glu Ile Leu Leu Ala 
        915                 920                 925             


Phe Ser Arg Asp Phe Leu Ser Gly Glu Gly Asp Leu Ser Arg His Leu 
    930                 935                 940                 


Gly Leu Leu Gly Leu Pro Val Asn His Val Gln Xaa Pro Phe Asp Glu 
945                 950                 955                 960 


Phe Asp Phe Ala Val Xaa Asn Leu Ala Val Asp Leu Gln Cys Gly Val 
                965                 970                 975     


Arg Leu Val Arg Xaa Met Glu Leu Leu Xaa Gln Asn Trp Asp Leu Ser 
            980                 985                 990         


Lys Lys Leu Arg Ile Pro Ala Ile  Ser Arg Leu Gln Lys  Met His Asn 
        995                 1000                 1005             


Val Asp  Ile Val Leu Gln Val  Leu Lys Ser Arg Gly  Ile Glu Leu 
    1010                 1015                 1020             


Ser Asp  Glu His Gly Asn Xaa  Ile Leu Ser Lys Asp  Ile Val Asp 
    1025                 1030                 1035             


Arg His  Arg Glu Lys Xaa Leu  Arg Leu Leu Trp Lys  Ile Ala Phe 
    1040                 1045                 1050             


Ala Phe  Gln Val Asp Ile Ser  Leu Asn Leu Asp Gln  Leu Lys Glu 
    1055                 1060                 1065             


Glu Ile  Ala Phe Leu Lys His  Xaa Lys Ser Ile Lys  Lys Xaa Ile 
    1070                 1075                 1080             


Ser Leu  Leu Ser Cys His Ser  Asp Asp Leu Ile Asn  Lys Lys Lys 
    1085                 1090                 1095             


Gly Lys  Arg Asp Ser Gly Ser  Phe Glu Gln Tyr Ser  Glu Asn Ile 
    1100                 1105                 1110             


Lys Leu  Leu Met Asp Trp Val  Asn Ala Val Cys Ala  Phe Tyr Asn 
    1115                 1120                 1125             


Lys Lys  Val Glu Asn Phe Xaa  Val Ser Phe Ser Asp  Gly Arg Val 
    1130                 1135                 1140             


Leu Cys  Tyr Leu Ile His His  Tyr His Pro Cys Tyr  Val Pro Phe 
    1145                 1150                 1155             


Asp Ala  Ile Cys Gln Arg Xaa  Xaa Gln Xaa Val Glu  Cys Xaa Gln 
    1160                 1165                 1170             


Xaa Gly  Ser Val Val Leu Asn  Ser Ser Ser Glu Ser  Asp Asp Ser 
    1175                 1180                 1185             


Ser Leu  Asp Met Ser Leu Lys  Ala Phe Asp His Glu  Asn Xaa Ser 
    1190                 1195                 1200             


Glu Leu  Tyr Lys Glu Leu Leu  Glu Asn Glu Lys Lys  Asn Phe His 
    1205                 1210                 1215             


Leu Val  Arg Ser Ala Val Arg  Asp Leu Gly Gly Ile  Pro Ala Met 
    1220                 1225                 1230             


Ile Asn  His Ser Asp Met Ser  Asn Xaa Ile Pro Asp  Glu Lys Val 
    1235                 1240                 1245             


Val Ile  Xaa Tyr Leu Ser Phe  Leu Cys Ala Arg Leu  Leu Asp Leu 
    1250                 1255                 1260             


Arg Lys  Glu Ile Arg Ala Ala  Arg Leu Ile Gln Xaa  Xaa Trp Arg 
    1265                 1270                 1275             


Lys Tyr  Lys Leu Lys Xaa Asp  Leu Lys Arg His Gln  Glu Arg Glu 
    1280                 1285                 1290             


Lys Ala  Ala Arg Ile Ile Gln  Leu Ala Val Ile Asn  Phe Leu Ala 
    1295                 1300                 1305             


Lys Gln  Arg Leu Arg Lys Arg  Val Asn Ala Ala Leu  Val Ile Gln 
    1310                 1315                 1320             


Lys Tyr  Trp Arg Arg Val Leu  Ala Gln Arg Lys Leu  Leu Met Leu 
    1325                 1330                 1335             


Lys Lys  Glu Lys Leu Glu Lys  Val Gln Asn Lys Ala  Ala Ser Leu 
    1340                 1345                 1350             


Ile Gln  Gly Tyr Trp Arg Arg  Tyr Ser Xaa Arg Gln  Arg Phe Leu 
    1355                 1360                 1365             


Lys Leu  Lys Tyr Tyr Ser Ile  Ile Leu Gln Ser Arg  Ile Arg Met 
    1370                 1375                 1380             


Ile Ile  Ala Val Xaa Ser Tyr  Lys Arg Tyr Leu Trp  Ala Xaa Val 
    1385                 1390                 1395             


Xaa Ile  Gln Arg His Trp Arg  Ala Tyr Leu Arg Arg  Lys Gln Asp 
    1400                 1405                 1410             


Gln Gln  Arg Tyr Glu Met Leu  Lys Ser Ser Xaa Leu  Ile Ile Gln 
    1415                 1420                 1425             


Ser Met  Phe Arg Lys Trp Lys  Gln Arg Lys Met Gln  Ser Gln Val 
    1430                 1435                 1440             


Lys Ala  Xaa Val Ile Leu Gln  Arg Ala Phe Arg Glu  Trp His Leu 
    1445                 1450                 1455             


Arg Lys  Gln Ala Lys Glu Glu  Asn Ser Ala Ile Ile  Ile Gln Ser 
    1460                 1465                 1470             


Trp Tyr  Arg Met His Lys Glu  Leu Arg Lys Tyr Ile  Tyr Ile Arg 
    1475                 1480                 1485             


Ser Cys  Val Val Ile Ile Gln  Lys Arg Phe Arg Cys  Phe Gln Ala 
    1490                 1495                 1500             


Gln Lys  Leu Tyr Lys Arg Arg  Lys Glu Ser Ile Leu  Xaa Ile Gln 
    1505                 1510                 1515             


Lys Tyr  Tyr Lys Ala Tyr Leu  Lys Gly Lys Ile Glu  Arg Xaa Asn 
    1520                 1525                 1530             


Tyr Leu  Gln Lys Arg Ala Ala  Ala Ile Gln Leu Gln  Ala Ala Phe 
    1535                 1540                 1545             


Arg Arg  Leu Lys Ala His Asn  Leu Cys Arg Gln Ile  Arg Ala Ala 
    1550                 1555                 1560             


Cys Val  Ile Gln Ser Tyr Trp  Arg Met Arg Gln Asp  Arg Val Arg 
    1565                 1570                 1575             


Phe Leu  Asn Leu Lys Lys Xaa  Ile Ile Lys Phe Gln  Ala His Val 
    1580                 1585                 1590             


Arg Lys  His Gln Gln Arg Gln  Lys Tyr Lys Lys Met  Lys Lys Ala 
    1595                 1600                 1605             


Ala Val  Ile Ile Gln Xaa His  Phe Arg Ala Tyr Ile  Phe Ala Met 
    1610                 1615                 1620             


Lys Val  Leu Ala Ser Tyr Gln  Lys Xaa Arg Ser Ala  Val Ile Val 
    1625                 1630                 1635             


Leu Gln  Ser Ala Tyr Arg Gly  Met Gln Ala Arg Lys  Met Tyr Ile 
    1640                 1645                 1650             


His Ile  Leu Xaa Ser Val Ile  Lys Ile Gln Ser Tyr  Tyr Arg Ala 
    1655                 1660                 1665             


Tyr Val  Ser Lys Lys Glu Phe  Leu Ser Leu Lys Asn  Ala Xaa Ile 
    1670                 1675                 1680             


Lys Leu  Gln Ser Xaa Val Lys  Met Lys Gln Xaa Arg  Lys Gln Tyr 
    1685                 1690                 1695             


Leu His  Leu Arg Ala Ala Ala  Leu Phe Ile Gln Gln  Cys Tyr Arg 
    1700                 1705                 1710             


Ser Lys  Lys Ile Ala Ala Gln  Lys Arg Glu Glu Tyr  Met Gln Met 
    1715                 1720                 1725             


Arg Glu  Ser Cys Ile Lys Leu  Gln Ala Phe Val Arg  Gly Tyr Leu 
    1730                 1735                 1740             


Val Arg  Lys Gln Met Arg Leu  Gln Arg Lys Ala Val  Ile Ser Leu 
    1745                 1750                 1755             


Gln Ser  Tyr Phe Arg Met Arg  Lys Ala Arg Gln Tyr  Tyr Leu Lys 
    1760                 1765                 1770             


Met Tyr  Lys Ala Ile Ile Val  Ile Gln Asn Tyr Tyr  His Ala Tyr 
    1775                 1780                 1785             


Lys Ala  Gln Val Asn Gln Arg  Lys Asn Phe Leu Gln  Val Lys Lys 
    1790                 1795                 1800             


Ala Ala  Xaa Cys Leu Gln Ala  Ala Tyr Arg Gly Tyr  Lys Val Arg 
    1805                 1810                 1815             


Gln Leu  Ile Lys Gln Gln Ser  Ile Ala Ala Leu Lys  Ile Gln Ser 
    1820                 1825                 1830             


Ala Phe  Arg Gly Tyr Asn Lys  Arg Val Lys Tyr Gln  Ser Val Leu 
    1835                 1840                 1845             


Gln Ser  Ile Ile Lys Ile Gln  Arg Trp Tyr Arg Ala  Tyr Lys Xaa 
    1850                 1855                 1860             


Leu His  Asp Xaa Arg Xaa His  Phe Leu Lys Xaa Lys  Ala Ala Val 
    1865                 1870                 1875             


Ile Ser  Leu Gln Ser Ala Tyr  Arg Gly Trp Lys Val  Arg Lys Gln 
    1880                 1885                 1890             


Ile Arg  Arg Glu His Gln Ala  Ala Leu Lys Ile Gln  Ser Ala Phe 
    1895                 1900                 1905             


Arg Met  Ala Lys Ala Gln Lys  Gln Phe Arg Leu Phe  Lys Xaa Ala 
    1910                 1915                 1920             


Ala Leu  Val Ile Gln Gln Asn  Phe Arg Ala Trp Xaa  Ala Gly Arg 
    1925                 1930                 1935             


Lys Gln  Cys Met Glu Tyr Ile  Glu Leu Arg His Ala  Val Leu Val 
    1940                 1945                 1950             


Leu Gln  Ser Met Trp Lys Gly  Lys Xaa Leu Arg Arg  Gln Leu Gln 
    1955                 1960                 1965             


Arg Gln  His Lys Cys Ala Ile  Ile Ile Gln Ser Tyr  Tyr Arg Met 
    1970                 1975                 1980             


His Val  Gln Gln Lys Lys Trp  Lys Ile Met Lys Lys  Ala Ala Leu 
    1985                 1990                 1995             


Leu Ile  Gln Lys Tyr Tyr Arg  Ala Tyr Ser Ile Gly  Arg Glu Gln 
    2000                 2005                 2010             


Asn His  Leu Tyr Leu Lys Xaa  Lys Ala Ala Val Val  Xaa Leu Gln 
    2015                 2020                 2025             


Ser Ala  Tyr Arg Gly Met Lys  Val Arg Lys Arg Ile  Lys Asp Cys 
    2030                 2035                 2040             


Asn Lys  Ala Ala Val Xaa Ile  Gln Ser Lys Tyr Arg  Ala Tyr Lys 
    2045                 2050                 2055             


Xaa Lys  Lys Lys Tyr Ala Xaa  Tyr Arg Ala Ser Ala  Ile Ile Ile 
    2060                 2065                 2070             


Gln Arg  Trp Tyr Arg Gly Ile  Lys Ile Xaa Asn His  Gln His Lys 
    2075                 2080                 2085             


Glu Tyr  Leu Asn Leu Lys Lys  Xaa Ala Ile Lys Ile  Gln Ser Val 
    2090                 2095                 2100             


Tyr Arg  Gly Ile Arg Val Arg  Arg His Ile Gln His  Met His Arg 
    2105                 2110                 2115             


Ala Ala  Xaa Phe Ile Lys Ala  Met Phe Lys Met His  Gln Ser Arg 
    2120                 2125                 2130             


Ile Ser  Tyr His Xaa Met Arg  Lys Ala Ala Ile Val  Ile Gln Val 
    2135                 2140                 2145             


Arg Cys  Arg Ala Tyr Tyr Gln  Gly Lys Met Gln Arg  Glu Lys Tyr 
    2150                 2155                 2160             


Leu Xaa  Ile Leu Lys Ala Val  Lys Val Leu Gln Ala  Ser Phe Arg 
    2165                 2170                 2175             


Gly Val  Arg Val Arg Arg Xaa  Leu Arg Lys Met Gln  Xaa Ala Ala 
    2180                 2185                 2190             


Xaa Leu  Ile Gln Ser Asn Tyr  Arg Arg Tyr Arg Gln  Gln Xaa Tyr 
    2195                 2200                 2205             


Phe Asn  Lys Leu Lys Lys Ile  Xaa Lys Xaa Val Gln  Gln Arg Tyr 
    2210                 2215                 2220             


Trp Ala  Met Lys Glu Arg Asn  Ile Gln Phe Gln Arg  Tyr Asn Lys 
    2225                 2230                 2235             


Leu Arg  His Ser Val Ile Tyr  Ile Gln Ala Ile Phe  Arg Gly Lys 
    2240                 2245                 2250             


Lys Ala  Arg Arg His Leu Lys  Met Met His Ile Ala  Ala Xaa Leu 
    2255                 2260                 2265             


Ile Gln  Arg Arg Phe Arg Xaa  Leu Met Met Arg Arg  Arg Phe Leu 
    2270                 2275                 2280             


Ser Leu  Lys Lys Xaa Ala Ile  Leu Ile Gln Arg Lys  Tyr Arg Ala 
    2285                 2290                 2295             


His Leu  Cys Xaa Lys His His  Leu Gln Phe Leu Gln  Val Gln Asn 
    2300                 2305                 2310             


Ala Val  Ile Lys Ile Gln Ser  Ser Tyr Arg Arg Trp  Met Ile Arg 
    2315                 2320                 2325             


Lys Arg  Met Arg Glu Met His  Arg Ala Ala Xaa Phe  Ile Gln Ser 
    2330                 2335                 2340             


Xaa Phe  Arg Met His Arg Leu  His Met Arg Tyr Gln  Ala Leu Lys 
    2345                 2350                 2355             


Gln Ala  Ser Val Val Ile Gln  Gln Gln Tyr Gln Ala  Asn Arg Ala 
    2360                 2365                 2370             


Ala Lys  Leu Gln Arg Gln His  Tyr Leu Arg Gln Arg  His Ser Ala 
    2375                 2380                 2385             


Val Ile  Leu Gln Ala Ala Phe  Arg Gly Met Lys Xaa  Arg Arg His 
    2390                 2395                 2400             


Leu Lys  Ser Met His Ser Ser  Ala Xaa Leu Ile Gln  Ser Arg Phe 
    2405                 2410                 2415             


Arg Ser  Leu Leu Val Arg Arg  Arg Phe Ile Ser Leu  Lys Lys Ala 
    2420                 2425                 2430             


Xaa Ile  Phe Val Gln Arg Lys  Tyr Arg Ala Xaa Ile  Cys Ala Lys 
    2435                 2440                 2445             


His Lys  Leu Tyr Gln Phe Leu  His Leu Arg Lys Ala  Ala Ile Xaa 
    2450                 2455                 2460             


Ile Gln  Ser Ser Tyr Arg Arg  Leu Met Val Lys Lys  Lys Leu Gln 
    2465                 2470                 2475             


Glu Met  Gln Arg Ala Ala Val  Leu Ile Gln Ala Xaa  Phe Arg Met 
    2480                 2485                 2490             


Tyr Arg  Xaa Tyr Ile Xaa Phe  Gln Xaa Trp Lys His  Ala Ser Ile 
    2495                 2500                 2505             


Leu Ile  Gln Gln His Tyr Arg  Xaa Tyr Arg Ala Ala  Lys Leu Gln 
    2510                 2515                 2520             


Arg Glu  Asn Tyr Ile Arg Gln  Trp His Ser Ala Val  Val Ile Gln 
    2525                 2530                 2535             


Ala Ala  Tyr Lys Gly Met Lys  Ala Arg Gln Leu Leu  Arg Glu Lys 
    2540                 2545                 2550             


His Lys  Ala Ser Ile Val Ile  Gln Ser Xaa Tyr Arg  Met Tyr Arg 
    2555                 2560                 2565             


Gln Tyr  Cys Phe Tyr Gln Lys  Leu Gln Trp Ala Xaa  Lys Ile Ile 
    2570                 2575                 2580             


Gln Glu  Lys Tyr Arg Ala Asn  Lys Lys Lys Gln Lys  Val Phe Gln 
    2585                 2590                 2595             


His Asn  Glu Leu Lys Lys Glu  Xaa Cys Val Gln Ala  Gly Phe Gln 
    2600                 2605                 2610             


Asp Met  Asn Ile Lys Lys Gln  Ile Gln Glu Gln His  Gln Ala Ala 
    2615                 2620                 2625             


Ile Ile  Ile Gln Lys His Cys  Lys Ala Phe Lys Ile  Arg Lys His 
    2630                 2635                 2640             


Tyr Leu  His Leu Arg Ala Xaa  Val Val Ser Ile Gln  Arg Arg Tyr 
    2645                 2650                 2655             


Arg Lys  Leu Xaa Ala Val Arg  Xaa Gln Ala Val Ile  Cys Ile Gln 
    2660                 2665                 2670             


Ser Tyr  Tyr Arg Gly Phe Lys  Val Arg Lys Asp Ile  Gln Asn Met 
    2675                 2680                 2685             


His Arg  Ala Ala Xaa Leu Ile  Gln Ser Phe Tyr Arg  Met His Arg 
    2690                 2695                 2700             


Ala Lys  Val Asp Tyr Glu Xaa  Lys Lys Xaa Ala Ile  Val Val Ile 
    2705                 2710                 2715             


Gln Asn  Tyr Tyr Arg Leu Tyr  Val Arg Val Lys Xaa  Glu Arg Lys 
    2720                 2725                 2730             


Asn Phe  Leu Ala Val Gln Lys  Ser Val Arg Xaa Ile  Gln Ala Ala 
    2735                 2740                 2745             


Phe Arg  Gly Met Lys Val Arg  Gln Lys Leu Lys Asn  Val Ser Glu 
    2750                 2755                 2760             


Glu Lys  Met Ala Ala Ile Val  Asn Gln Ser Ala Leu  Cys Cys Tyr 
    2765                 2770                 2775             


Arg Ser  Lys Xaa Gln Tyr Glu  Ala Val Gln Ser Glu  Gly Val Met 
    2780                 2785                 2790             


Ile Gln  Glu Trp Tyr Lys Ala  Ser Gly Leu Ala Cys  Ser Gln Glu 
    2795                 2800                 2805             


Ala Glu  Tyr His Ser Gln Ser  Arg Ala Ala Val Xaa  Ile Gln Lys 
    2810                 2815                 2820             


Ala Phe  Cys Arg Met Val Xaa  Arg Lys Leu Glu Xaa  Gln Lys Cys 
    2825                 2830                 2835             


Ala Ala  Leu Arg Ile Gln Phe  Phe Leu Gln Met Ala  Val Tyr Arg 
    2840                 2845                 2850             


Arg Arg  Phe Val Gln Gln Lys  Arg Ala Ala Ile Xaa  Leu Gln His 
    2855                 2860                 2865             


Tyr Phe  Arg Xaa Trp Gln Xaa  Arg Lys Gln Phe Leu  Leu Tyr Arg 
    2870                 2875                 2880             


Lys Ala  Ala Val Val Leu Gln  Asn His Tyr Arg Ala  Phe Leu Ser 
    2885                 2890                 2895             


Ala Lys  His Gln Arg Gln Val  Tyr Leu Gln Ile Arg  Ser Ser Val 
    2900                 2905                 2910             


Ile Ile  Ile Gln Ala Arg Ser  Lys Gly Phe Ile Gln  Lys Arg Lys 
    2915                 2920                 2925             


Phe Gln  Glu Ile Lys Asn Ser  Xaa Ile Lys Ile Gln  Ala Met Trp 
    2930                 2935                 2940             


Arg Arg  Tyr Arg Ala Lys Lys  Tyr Leu Cys Lys Val  Lys Ala Ala 
    2945                 2950                 2955             


Cys Lys  Ile Gln Ala Trp Tyr  Arg Cys Trp Arg Ala  His Lys Glu 
    2960                 2965                 2970             


Tyr Leu  Ala Ile Leu Lys Ala  Val Lys Ile Ile Gln  Gly Cys Phe 
    2975                 2980                 2985             


Tyr Xaa  Lys Leu Glu Arg Xaa  Arg Phe Leu Asn Val  Arg Ala Ser 
    2990                 2995                 3000             


Ala Ile  Ile Ile Gln Arg Lys  Trp Arg Ala Ile Leu  Pro Ala Lys 
    3005                 3010                 3015             


Ile Ala  His Glu His Phe Leu  Met Ile Lys Arg His  Arg Ala Ala 
    3020                 3025                 3030             


Cys Leu  Ile Gln Ala His Tyr  Arg Gly Tyr Lys Gly  Arg Gln Val 
    3035                 3040                 3045             


Phe Leu  Arg Gln Lys Ser Ala  Ala Leu Ile Ile Gln  Lys Tyr Ile 
    3050                 3055                 3060             


Arg Ala  Arg Glu Ala Gly Lys  His Glu Arg Ile Lys  Tyr Ile Glu 
    3065                 3070                 3075             


Phe Lys  Lys Ser Xaa Val Ile  Leu Gln Ala Leu Val  Arg Gly Trp 
    3080                 3085                 3090             


Leu Val  Arg Lys Arg Phe Leu  Glu Gln Arg Ala Lys  Ile Arg Leu 
    3095                 3100                 3105             


Leu His  Phe Xaa Ala Ala Ala  Tyr Tyr His Leu Asn  Ala Val Arg 
    3110                 3115                 3120             


Ile Gln  Arg Ala Tyr Lys Leu  Tyr Leu Ala Val Lys  Asn Ala Asn 
    3125                 3130                 3135             


Lys Gln  Val Asn Ser Val Ile  Cys Ile Gln Arg Trp  Phe Arg Ala 
    3140                 3145                 3150             


Arg Leu  Gln Glu Lys Arg Phe  Ile Gln Lys Tyr His  Ser Ile Lys 
    3155                 3160                 3165             


Lys Ile  Glu His Glu Gly Gln  Glu Cys Leu Ser Gln  Arg Asn Arg 
    3170                 3175                 3180             


Ala Ala  Ser Val Ile Gln Lys  Ala Val Arg His Phe  Leu Leu Arg 
    3185                 3190                 3195             


Lys Lys  Gln Glu Lys Phe Xaa  Ser Gly Ile Ile Lys  Ile Gln Ala 
    3200                 3205                 3210             


Leu Trp  Arg Gly Tyr Ser Trp  Arg Lys Lys Asn Asp  Cys Xaa Lys 
    3215                 3220                 3225             


Ile Lys  Ala Ile Arg Leu Ser  Leu Gln Val Val Asn  Arg Glu Ile 
    3230                 3235                 3240             


Arg Glu  Glu Asn Lys Leu Tyr  Lys Arg Xaa Ala Leu  Ala Leu His 
    3245                 3250                 3255             


Tyr Leu  Leu Xaa Tyr Lys His  Leu Ser Ala Ile Leu  Glu Ala Leu 
    3260                 3265                 3270             


Lys His  Leu Glu Val Val Xaa  Arg Leu Ser Pro Leu  Cys Cys Glu 
    3275                 3280                 3285             


Asn Met  Ala Gln Ser Gly Ala  Ile Ser Lys Ile Phe  Val Leu Ile 
    3290                 3295                 3300             


Arg Ser  Cys Asn Arg Ser Ile  Pro Cys Met Glu Val  Ile Arg Tyr 
    3305                 3310                 3315             


Ala Val  Gln Val Leu Leu Asn  Val Ser Lys Tyr Glu  Lys Xaa Xaa 
    3320                 3325                 3330             


Ser Ala  Val Tyr Asp Val Glu  Asn Cys Ile Asp Ile  Leu Leu Glu 
    3335                 3340                 3345             


Leu Leu  Gln Ile Tyr Arg Glu  Lys Pro Gly Asn Lys  Val Ala Asp 
    3350                 3355                 3360             


Lys Gly  Gly Ser Ile Phe Xaa  Lys Xaa Cys Cys Leu  Leu Ala Ile 
    3365                 3370                 3375             


Leu Leu  Lys Xaa Xaa Asn Arg  Ala Ser Asp Val Arg  Ser Arg Ser 
    3380                 3385                 3390             


Lys Val  Val Asp Arg Ile Tyr  Ser Leu Tyr Lys Leu  Xaa Ala His 
    3395                 3400                 3405             


Lys His  Lys Met Asn Xaa Glu  Arg Ile Leu Tyr Lys  Gln Lys Lys 
    3410                 3415                 3420             


Asn Ser  Ser Ile Ser Ile Pro  Phe Ile Pro Glu Xaa  Pro Val Arg 
    3425                 3430                 3435             


Xaa Arg  Ile Val Ser Arg Leu  Lys Pro Asp Trp Val  Leu Arg Arg 
    3440                 3445                 3450             


Asp Asn  Met Glu Glu Ile Xaa  Asn Pro Leu Gln Ala  Ile Gln Met 
    3455                 3460                 3465             


Val Met  Asp Xaa Leu Gly Ile  Pro Tyr 
    3470                 3475         


<210> 3434
<211> 1142
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1071)..(1071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<400> 3434
Met Ser Leu Arg Ala Tyr Xaa Ala Arg Cys Arg Leu Asn Arg Leu Arg 
1               5                   10                  15      


Arg Ala Ala Cys Arg Leu Phe Xaa Ser Glu Lys Met Val Lys Ala Ile 
            20                  25                  30          


Lys Lys Leu Glu Ile Glu Ile Glu Ala Arg Arg Leu Ile Val Arg Lys 
        35                  40                  45              


Asp Arg His Leu Trp Lys Asp Val Gly Glu Arg Gln Lys Val Leu Asn 
    50                  55                  60                  


Trp Leu Leu Ser Tyr Asn Pro Leu Trp Leu Arg Ile Gly Leu Glu Xaa 
65                  70                  75                  80  


Xaa Tyr Gly Glu Leu Ile Ser Leu Glu Asp Asn Ser Asp Val Xaa Gly 
                85                  90                  95      


Leu Ala Met Phe Ile Leu Asn Arg Leu Leu Trp Asn Pro Asp Ile Ala 
            100                 105                 110         


Ala Glu Tyr Arg His Pro Xaa Val Pro His Leu Tyr Arg Asp Gly His 
        115                 120                 125             


Glu Glu Ala Leu Ser Lys Phe Xaa Leu Lys Lys Leu Leu Leu Leu Val 
    130                 135                 140                 


Cys Phe Leu Asp Tyr Ala Lys Ile Ser Arg Leu Ile Asp His Asp Pro 
145                 150                 155                 160 


Cys Leu Phe Cys Lys Asp Ala Glu Phe Lys Ala Ser Lys Glu Ile Leu 
                165                 170                 175     


Leu Ala Phe Ser Arg Asp Phe Leu Ser Gly Glu Gly Asp Leu Ser Arg 
            180                 185                 190         


His Leu Gly Leu Leu Gly Leu Pro Val Asn His Val Gln Xaa Pro Phe 
        195                 200                 205             


Asp Glu Phe Asp Phe Ala Val Xaa Asn Leu Ala Val Asp Leu Gln Cys 
    210                 215                 220                 


Gly Val Arg Leu Val Arg Xaa Met Glu Leu Leu Xaa Gln Asn Trp Asp 
225                 230                 235                 240 


Leu Ser Lys Lys Leu Arg Ile Pro Ala Ile Ser Arg Leu Gln Lys Met 
                245                 250                 255     


His Asn Val Asp Ile Val Leu Gln Val Leu Lys Ser Arg Gly Ile Glu 
            260                 265                 270         


Leu Ser Asp Glu His Gly Asn Xaa Ile Leu Ser Lys Asp Ile Val Asp 
        275                 280                 285             


Arg His Arg Glu Lys Xaa Leu Arg Leu Leu Trp Lys Ile Ala Phe Ala 
    290                 295                 300                 


Phe Gln Val Asp Ile Ser Leu Asn Leu Asp Gln Leu Lys Glu Glu Ile 
305                 310                 315                 320 


Ala Phe Leu Lys His Xaa Lys Ser Ile Lys Lys Xaa Ile Ser Leu Leu 
                325                 330                 335     


Ser Cys His Ser Asp Asp Leu Ile Asn Lys Lys Lys Gly Lys Arg Asp 
            340                 345                 350         


Ser Gly Ser Phe Glu Gln Tyr Ser Glu Asn Ile Lys Leu Leu Met Asp 
        355                 360                 365             


Trp Val Asn Ala Val Cys Ala Phe Tyr Asn Lys Lys Val Glu Asn Phe 
    370                 375                 380                 


Xaa Val Ser Phe Ser Asp Gly Arg Val Leu Cys Tyr Leu Ile His His 
385                 390                 395                 400 


Tyr His Pro Cys Tyr Val Pro Phe Asp Ala Ile Cys Gln Arg Xaa Xaa 
                405                 410                 415     


Gln Xaa Val Glu Cys Xaa Gln Xaa Gly Ser Val Val Leu Asn Ser Ser 
            420                 425                 430         


Ser Glu Ser Asp Asp Ser Ser Leu Asp Met Ser Leu Lys Ala Phe Asp 
        435                 440                 445             


His Glu Asn Xaa Ser Glu Leu Tyr Lys Glu Leu Leu Glu Asn Glu Lys 
    450                 455                 460                 


Lys Asn Phe His Leu Val Arg Ser Ala Val Arg Asp Leu Gly Gly Ile 
465                 470                 475                 480 


Pro Ala Met Ile Asn His Ser Asp Met Ser Asn Xaa Ile Pro Asp Glu 
                485                 490                 495     


Lys Val Val Ile Xaa Tyr Leu Ser Phe Leu Cys Ala Arg Leu Leu Asp 
            500                 505                 510         


Leu Arg Lys Glu Ile Arg Ala Ala Arg Leu Ile Gln Xaa Xaa Trp Arg 
        515                 520                 525             


Lys Tyr Lys Leu Lys Xaa Asp Leu Lys Arg His Gln Glu Arg Glu Lys 
    530                 535                 540                 


Ala Ala Arg Ile Ile Gln Leu Ala Val Ile Asn Phe Leu Ala Lys Gln 
545                 550                 555                 560 


Arg Leu Arg Lys Arg Val Asn Ala Ala Leu Val Ile Gln Lys Tyr Trp 
                565                 570                 575     


Arg Arg Val Leu Ala Gln Arg Lys Leu Leu Met Leu Lys Lys Glu Lys 
            580                 585                 590         


Leu Glu Lys Val Gln Asn Lys Ala Ala Ser Leu Ile Gln Ala Met Trp 
        595                 600                 605             


Arg Arg Tyr Arg Ala Lys Lys Tyr Leu Cys Lys Val Lys Ala Ala Cys 
    610                 615                 620                 


Lys Ile Gln Ala Trp Tyr Arg Cys Trp Arg Ala His Lys Glu Tyr Leu 
625                 630                 635                 640 


Ala Ile Leu Lys Ala Val Lys Ile Ile Gln Gly Cys Phe Tyr Xaa Lys 
                645                 650                 655     


Leu Glu Arg Xaa Arg Phe Leu Asn Val Arg Ala Ser Ala Ile Ile Ile 
            660                 665                 670         


Gln Arg Lys Trp Arg Ala Ile Leu Pro Ala Lys Ile Ala His Glu His 
        675                 680                 685             


Phe Leu Met Ile Lys Arg His Arg Ala Ala Cys Leu Ile Gln Ala His 
    690                 695                 700                 


Tyr Arg Gly Tyr Lys Gly Arg Gln Val Phe Leu Arg Gln Lys Ser Ala 
705                 710                 715                 720 


Ala Leu Ile Ile Gln Lys Tyr Ile Arg Ala Arg Glu Ala Gly Lys His 
                725                 730                 735     


Glu Arg Ile Lys Tyr Ile Glu Phe Lys Lys Ser Xaa Val Ile Leu Gln 
            740                 745                 750         


Ala Leu Val Arg Gly Trp Leu Val Arg Lys Arg Phe Leu Glu Gln Arg 
        755                 760                 765             


Ala Lys Ile Arg Leu Leu His Phe Xaa Ala Ala Ala Tyr Tyr His Leu 
    770                 775                 780                 


Asn Ala Val Arg Ile Gln Arg Ala Tyr Lys Leu Tyr Leu Ala Val Lys 
785                 790                 795                 800 


Asn Ala Asn Lys Gln Val Asn Ser Val Ile Cys Ile Gln Arg Trp Phe 
                805                 810                 815     


Arg Ala Arg Leu Gln Glu Lys Arg Phe Ile Gln Lys Tyr His Ser Ile 
            820                 825                 830         


Lys Lys Ile Glu His Glu Gly Gln Glu Cys Leu Ser Gln Arg Asn Arg 
        835                 840                 845             


Ala Ala Ser Val Ile Gln Lys Ala Val Arg His Phe Leu Leu Arg Lys 
    850                 855                 860                 


Lys Gln Glu Lys Phe Xaa Ser Gly Ile Ile Lys Ile Gln Ala Leu Trp 
865                 870                 875                 880 


Arg Gly Tyr Ser Trp Arg Lys Lys Asn Asp Cys Xaa Lys Ile Lys Ala 
                885                 890                 895     


Ile Arg Leu Ser Leu Gln Val Val Asn Arg Glu Ile Arg Glu Glu Asn 
            900                 905                 910         


Lys Leu Tyr Lys Arg Xaa Ala Leu Ala Leu His Tyr Leu Leu Xaa Tyr 
        915                 920                 925             


Lys His Leu Ser Ala Ile Leu Glu Ala Leu Lys His Leu Glu Val Val 
    930                 935                 940                 


Xaa Arg Leu Ser Pro Leu Cys Cys Glu Asn Met Ala Gln Ser Gly Ala 
945                 950                 955                 960 


Ile Ser Lys Ile Phe Val Leu Ile Arg Ser Cys Asn Arg Ser Ile Pro 
                965                 970                 975     


Cys Met Glu Val Ile Arg Tyr Ala Val Gln Val Leu Leu Asn Val Ser 
            980                 985                 990         


Lys Tyr Glu Lys Xaa Xaa Ser Ala  Val Tyr Asp Val Glu  Asn Cys Ile 
        995                 1000                 1005             


Asp Ile  Leu Leu Glu Leu Leu  Gln Ile Tyr Arg Glu  Lys Pro Gly 
    1010                 1015                 1020             


Asn Lys  Val Ala Asp Lys Gly  Gly Ser Ile Phe Xaa  Lys Xaa Cys 
    1025                 1030                 1035             


Cys Leu  Leu Ala Ile Leu Leu  Lys Xaa Xaa Asn Arg  Ala Ser Asp 
    1040                 1045                 1050             


Val Arg  Ser Arg Ser Lys Val  Val Asp Arg Ile Tyr  Ser Leu Tyr 
    1055                 1060                 1065             


Lys Leu  Xaa Ala His Lys His  Lys Met Asn Xaa Glu  Arg Ile Leu 
    1070                 1075                 1080             


Tyr Lys  Gln Lys Lys Asn Ser  Ser Ile Ser Ile Pro  Phe Ile Pro 
    1085                 1090                 1095             


Glu Xaa  Pro Val Arg Xaa Arg  Ile Val Ser Arg Leu  Lys Pro Asp 
    1100                 1105                 1110             


Trp Val  Leu Arg Arg Asp Asn  Met Glu Glu Ile Xaa  Asn Pro Leu 
    1115                 1120                 1125             


Gln Ala  Ile Gln Met Val Met  Asp Xaa Leu Gly Ile  Pro Tyr 
    1130                 1135                 1140         


<210> 3435
<211> 243
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<400> 3435
Met Lys Glu Tyr Val Leu Leu Leu Phe Leu Ala Leu Cys Ser Ala Lys 
1               5                   10                  15      


Pro Phe Phe Ser Pro Ser His Ile Ala Leu Lys Asn Met Met Leu Lys 
            20                  25                  30          


Asp Met Glu Asp Xaa Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
        35                  40                  45              


Asp Asp Asp Glu Asp Asn Ser Leu Phe Pro Xaa Arg Glu Pro Arg Ser 
    50                  55                  60                  


His Phe Phe Pro Phe Asp Leu Phe Pro Met Cys Pro Phe Gly Cys Gln 
65                  70                  75                  80  


Cys Tyr Ser Arg Val Val His Cys Ser Asp Leu Gly Leu Xaa Ser Val 
                85                  90                  95      


Pro Xaa Asn Ile Pro Phe Asp Xaa Arg Met Leu Asp Leu Gln Asn Asn 
            100                 105                 110         


Lys Ile Lys Glu Ile Lys Glu Asn Asp Phe Lys Gly Leu Xaa Ser Leu 
        115                 120                 125             


Tyr Gly Leu Ile Leu Asn Asn Asn Lys Leu Xaa Lys Ile His Pro Lys 
    130                 135                 140                 


Ala Phe Leu Xaa Xaa Lys Lys Leu Arg Arg Leu Tyr Leu Ser His Asn 
145                 150                 155                 160 


Gln Leu Ser Glu Ile Pro Leu Asn Leu Pro Lys Ser Leu Ala Glu Leu 
                165                 170                 175     


Arg Ile His Glu Asn Lys Val Lys Lys Ile Gln Lys Asp Xaa Phe Lys 
            180                 185                 190         


Gly Met Asn Ala Leu His Val Leu Glu Met Ser Ala Asn Pro Leu Asp 
        195                 200                 205             


Asn Asn Gly Ile Glu Pro Gly Ala Phe Glu Gly Val Xaa Val Phe His 
    210                 215                 220                 


Ile Arg Ile Ala Glu Ala Lys Leu Xaa Ser Val Pro Lys Asp Asn Leu 
225                 230                 235                 240 


Pro Ser Phe 
            


<210> 3436
<211> 380
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<400> 3436
Met Lys Glu Tyr Val Leu Leu Leu Phe Leu Ala Leu Cys Ser Ala Lys 
1               5                   10                  15      


Pro Phe Phe Ser Pro Ser His Ile Ala Leu Lys Asn Met Met Leu Lys 
            20                  25                  30          


Asp Met Glu Asp Xaa Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
        35                  40                  45              


Asp Asp Asp Glu Asp Asn Ser Leu Phe Pro Xaa Arg Glu Pro Arg Ser 
    50                  55                  60                  


His Phe Phe Pro Phe Asp Leu Phe Pro Met Cys Pro Phe Gly Cys Gln 
65                  70                  75                  80  


Cys Tyr Ser Arg Val Val His Cys Ser Asp Leu Gly Leu Xaa Ser Val 
                85                  90                  95      


Pro Xaa Asn Ile Pro Phe Asp Xaa Arg Met Leu Asp Leu Gln Asn Asn 
            100                 105                 110         


Lys Ile Lys Glu Ile Lys Glu Asn Asp Phe Lys Gly Leu Xaa Ser Leu 
        115                 120                 125             


Tyr Gly Leu Ile Leu Asn Asn Asn Lys Leu Xaa Lys Ile His Pro Lys 
    130                 135                 140                 


Ala Phe Leu Xaa Xaa Lys Lys Leu Arg Arg Leu Tyr Leu Ser His Asn 
145                 150                 155                 160 


Gln Leu Ser Glu Ile Pro Leu Asn Leu Pro Lys Ser Leu Ala Glu Leu 
                165                 170                 175     


Arg Ile His Glu Asn Lys Val Lys Lys Ile Gln Lys Asp Xaa Phe Lys 
            180                 185                 190         


Gly Met Asn Ala Leu His Val Leu Glu Met Ser Ala Asn Pro Leu Asp 
        195                 200                 205             


Asn Asn Gly Ile Glu Pro Gly Ala Phe Glu Gly Val Xaa Val Phe His 
    210                 215                 220                 


Ile Arg Ile Ala Glu Ala Lys Leu Xaa Ser Val Pro Lys Gly Leu Pro 
225                 230                 235                 240 


Pro Xaa Leu Leu Glu Leu His Leu Asp Tyr Asn Lys Ile Ser Xaa Val 
                245                 250                 255     


Glu Leu Glu Asp Phe Lys Arg Tyr Lys Glu Leu Gln Arg Leu Gly Leu 
            260                 265                 270         


Gly Asn Asn Lys Ile Xaa Asp Ile Glu Asn Gly Ser Leu Ala Asn Ile 
        275                 280                 285             


Pro Arg Val Arg Glu Ile His Leu Glu Asn Asn Lys Leu Lys Lys Ile 
    290                 295                 300                 


Pro Ser Gly Leu Pro Glu Leu Lys Tyr Leu Gln Ile Ile Phe Leu His 
305                 310                 315                 320 


Ser Asn Ser Ile Ala Arg Val Gly Val Asn Asp Phe Cys Pro Xaa Val 
                325                 330                 335     


Pro Lys Met Lys Lys Ser Leu Tyr Ser Ala Ile Ser Leu Phe Asn Asn 
            340                 345                 350         


Pro Val Lys Tyr Trp Glu Met Gln Pro Ala Xaa Phe Arg Cys Val Leu 
        355                 360                 365             


Ser Arg Met Ser Val Gln Leu Gly Asn Phe Gly Met 
    370                 375                 380 


<210> 3437
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 3437
Met Gly Val Val Asn Phe Val Phe Arg Ala Ser Glu Asp Leu Gln Val 
1               5                   10                  15      


Leu Glu Asn Tyr Ser Asp Ala Pro Met Xaa Pro Lys Gln Ile Leu Gln 
            20                  25                  30          


Val Ile Glu Ala Glu Gly Leu Lys Glu Met Arg Ser Gly Xaa Ser Pro 
        35                  40                  45              


Leu Ala Cys Leu Asn Ala Met Leu His Ser Asn Ser Arg Gly Gly Glu 
    50                  55                  60                  


Gly Leu Phe Tyr Lys Leu Pro Gly Arg Ile Ser Leu Phe Xaa Leu Lys 
65                  70                  75                  80  


Val 
    


<210> 3438
<211> 1536
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (996)..(996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1179)..(1179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1189)..(1189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1262)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1282)..(1282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1293)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1308)..(1308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1346)..(1346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1367)..(1367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1383)..(1383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1447)..(1447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1489)..(1489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1493)..(1493)
<223> Selenocysteine

<400> 3438
Met Gly Val Val Asn Phe Val Phe Arg Ala Ser Glu Asp Leu Gln Val 
1               5                   10                  15      


Leu Glu Asn Tyr Ser Asp Ala Pro Met Xaa Pro Lys Gln Ile Leu Gln 
            20                  25                  30          


Val Ile Glu Ala Glu Gly Leu Lys Glu Met Ser Gly Xaa Ser Pro Leu 
        35                  40                  45              


Ala Cys Leu Asn Ala Met Leu His Ser Asn Ser Arg Gly Gly Glu Gly 
    50                  55                  60                  


Leu Phe Tyr Lys Leu Pro Gly Arg Ile Ser Leu Phe Xaa Leu Lys Lys 
65                  70                  75                  80  


Asp Ala Leu Gln Trp Ser Arg His Pro Ala Xaa Val Glu Gly Glu Glu 
                85                  90                  95      


Pro Glu Asp Xaa Ala Asp Val Glu Ser Cys Gly Ser Asn Glu Ala Ser 
            100                 105                 110         


Xaa Val Ser Gly Glu Asn Asp Val Ser Leu Asp Glu Xaa Ser Ser Asn 
        115                 120                 125             


Ala Ser Cys Ser Xaa Glu Ser Gln Ser Arg Pro Leu Ser Asn Pro Arg 
    130                 135                 140                 


Asp Ser Tyr Arg Ala Ser Ser Gln Ala Asn Lys Gln Lys Lys Lys Xaa 
145                 150                 155                 160 


Gly Val Met Leu Pro Arg Val Val Leu Xaa Pro Leu Lys Val Asn Gly 
                165                 170                 175     


Ala His Val Glu Ser Ala Ser Gly Phe Ser Gly Cys His Ala Asp Gly 
            180                 185                 190         


Glu Ser Gly Ser Pro Ser Ser Ser Ser Ser Gly Ser Leu Ala Leu Gly 
        195                 200                 205             


Ser Ala Ala Ile Arg Gly Gln Ala Glu Val Xaa Gln Asp Pro Ala Pro 
    210                 215                 220                 


Leu Leu Arg Gly Phe Arg Lys Pro Ala Xaa Gly Gln Met Lys Arg Asn 
225                 230                 235                 240 


Arg Gly Glu Glu Ile Asp Phe Glu Xaa Pro Gly Ser Ile Leu Val Asn 
                245                 250                 255     


Xaa Asn Leu Arg Ala Leu Ile Asn Ser Arg Xaa Phe His Ala Leu Pro 
            260                 265                 270         


Ser His Phe Gln Gln Gln Leu Leu Phe Leu Leu Pro Glu Val Asp Arg 
        275                 280                 285             


Gln Val Gly Xaa Asp Gly Leu Leu Arg Leu Ser Ser Ser Ala Leu Asn 
    290                 295                 300                 


Asn Glu Phe Phe Xaa His Ala Ala Gln Ser Trp Arg Glu Arg Leu Ala 
305                 310                 315                 320 


Asp Gly Glu Phe Xaa His Glu Met Gln Val Arg Ile Arg Gln Glu Met 
                325                 330                 335     


Glu Lys Glu Lys Lys Val Glu Gln Trp Lys Glu Lys Phe Phe Glu Asp 
            340                 345                 350         


Tyr Tyr Gly Gln Lys Leu Gly Leu Xaa Lys Glu Glu Ser Leu Gln Gln 
        355                 360                 365             


Asn Val Gly Gln Glu Glu Ala Glu Ile Lys Ser Gly Leu Cys Val Pro 
    370                 375                 380                 


Gly Glu Ser Val Arg Ile Gln Arg Gly Pro Ala Xaa Arg Gln Arg Asp 
385                 390                 395                 400 


Gly His Phe Lys Lys Arg Ser Arg Pro Asp Leu Arg Xaa Arg Ala Arg 
                405                 410                 415     


Arg Asn Leu Tyr Lys Lys Gln Glu Ser Glu Gln Ala Gly Val Ala Lys 
            420                 425                 430         


Asp Ala Lys Ser Val Ala Ser Asp Val Pro Leu Tyr Lys Asp Gly Glu 
        435                 440                 445             


Ala Lys Xaa Asp Pro Ala Gly Leu Ser Ser Pro His Leu Pro Gly Xaa 
    450                 455                 460                 


Ser Ser Ala Ala Pro Asp Leu Glu Gly Pro Glu Phe Pro Val Glu Ser 
465                 470                 475                 480 


Val Ala Ser Arg Ile Gln Ala Glu Pro Asp Asn Leu Ala Arg Ala Ser 
                485                 490                 495     


Ala Ser Pro Asp Arg Ile Pro Ser Leu Pro Gln Glu Xaa Val Asp Gln 
            500                 505                 510         


Glu Pro Lys Asp Gln Lys Arg Lys Ser Phe Glu Gln Ala Ala Ser Ala 
        515                 520                 525             


Ser Phe Pro Glu Lys Lys Pro Arg Leu Glu Asp Arg Gln Ser Phe Arg 
    530                 535                 540                 


Asn Xaa Ile Glu Ser Val His Xaa Glu Lys Pro Gln Pro Xaa Lys Glu 
545                 550                 555                 560 


Glu Pro Lys Val Pro Pro Ile Arg Ile Gln Leu Ser Arg Ile Lys Pro 
                565                 570                 575     


Pro Trp Val Val Lys Gly Gln Pro Xaa Tyr Gln Ile Cys Pro Arg Ile 
            580                 585                 590         


Ile Pro Xaa Xaa Glu Ser Ser Cys Arg Gly Trp Xaa Gly Ala Arg Xaa 
        595                 600                 605             


Leu Ala Asp Ile Lys Ala Arg Ala Leu Gln Val Arg Gly Ala Arg Gly 
    610                 615                 620                 


His His Cys His Arg Glu Ala Ala Xaa Xaa Ala Ile Gly Gly Gly Gly 
625                 630                 635                 640 


Gly Pro Gly Gly Gly Gly Gly Gly Ala Xaa Asp Glu Gly Gly Gly Arg 
                645                 650                 655     


Gly Ser Ser Ser Gly Asp Gly Gly Glu Ala Cys Gly His Pro Glu Pro 
            660                 665                 670         


Arg Gly Gly Pro Ser Xaa Pro Gly Lys Cys Xaa Ser Asp Leu Gln Arg 
        675                 680                 685             


Xaa Gln Leu Leu Pro Pro Tyr Pro Leu Asn Gly Glu His Xaa Gln Ala 
    690                 695                 700                 


Gly Xaa Ala Met Ser Arg Ala Arg Arg Glu Asp Leu Pro Ser Leu Arg 
705                 710                 715                 720 


Lys Glu Glu Ser Cys Leu Leu Gln Arg Ala Xaa Val Gly Leu Xaa Asp 
                725                 730                 735     


Gly Leu Gly Asp Ala Ser Gln Leu Pro Val Ala Pro Xaa Gly Asp Gln 
            740                 745                 750         


Pro Cys Gln Ala Leu Pro Leu Leu Ser Ser Gln Xaa Ser Val Ala Glu 
        755                 760                 765             


Arg Leu Val Glu Gln Pro Gln Leu His Pro Asp Val Arg Xaa Glu Cys 
    770                 775                 780                 


Glu Ser Gly Xaa Xaa Ser Trp Glu Ser Asp Asp Glu Glu Gln Gly Pro 
785                 790                 795                 800 


Xaa Val Pro Ala Asp Asn Gly Pro Ile Pro Ser Leu Val Gly Asp Asp 
                805                 810                 815     


Xaa Leu Glu Lys Gly Xaa Gly Gln Ala Leu Asp Ser His Pro Xaa Met 
            820                 825                 830         


Lys Asp Pro Val Asn Val Xaa Pro Ser Ser Xaa Pro Glu Ser Ser Pro 
        835                 840                 845             


Xaa Asp Cys Leu Gln Asn Arg Ala Phe Asp Asp Glu Leu Gly Leu Gly 
    850                 855                 860                 


Gly Ser Cys Pro Pro Met Arg Glu Ser Asp Xaa Arg Gln Glu Asn Leu 
865                 870                 875                 880 


Lys Xaa Lys Ala Leu Val Ser Asn Ser Ser Leu His Trp Ile Pro Ile 
                885                 890                 895     


Pro Ser Asn Asp Glu Val Val Lys Gln Pro Lys Pro Glu Ser Arg Glu 
            900                 905                 910         


His Ile Pro Ser Val Glu Pro Gln Val Gly Glu Glu Trp Glu Lys Ala 
        915                 920                 925             


Ala Pro Xaa Pro Pro Ala Leu Pro Gly Asp Leu Xaa Ala Glu Glu Gly 
    930                 935                 940                 


Leu Asp Pro Leu Asp Ser Leu Xaa Ser Leu Trp Xaa Val Pro Ser Arg 
945                 950                 955                 960 


Gly Gly Ser Asp Ser Asn Gly Ser Tyr Cys Gln Gln Val Asp Ile Glu 
                965                 970                 975     


Lys Leu Lys Ile Asn Gly Asp Ser Glu Ala Leu Ser Pro His Gly Glu 
            980                 985                 990         


Ser Xaa Asp Xaa Ala Ser Asp Phe  Glu Gly His Leu Xaa  Glu Asp Ser 
        995                 1000                 1005             


Ser Glu  Ala Asp Xaa Arg Glu  Ala Ala Val Xaa Lys  Gly Ser Ser 
    1010                 1015                 1020             


Val Asp  Lys Asp Glu Lys Pro  Asn Trp Asn Gln Ser  Ala Pro Leu 
    1025                 1030                 1035             


Ser Lys  Val Asn Gly Asp Met  Arg Leu Val Xaa Arg  Xaa Asp Gly 
    1040                 1045                 1050             


Met Val  Ala Pro Gln Ser Trp  Val Ser Arg Val Cys  Ala Val Arg 
    1055                 1060                 1065             


Gln Lys  Ile Pro Asp Ser Leu  Leu Leu Ala Ser Xaa  Glu Tyr Gln 
    1070                 1075                 1080             


Pro Arg  Ala Val Cys Leu Ser  Met Pro Gly Ser Ser  Val Glu Ala 
    1085                 1090                 1095             


Xaa Asn  Pro Leu Val Met Gln  Leu Leu Gln Gly Ser  Leu Pro Leu 
    1100                 1105                 1110             


Glu Lys  Val Leu Pro Pro Ala  His Asp Asp Ser Met  Ser Glu Ser 
    1115                 1120                 1125             


Pro Gln  Val Pro Leu Xaa Lys  Asp Gln Ser His Gly  Ser Leu Arg 
    1130                 1135                 1140             


Met Gly  Ser Leu His Gly Leu  Gly Lys Asn Ser Gly  Met Val Asp 
    1145                 1150                 1155             


Gly Ser  Ser Pro Ser Ser Leu  Arg Ala Leu Lys Glu  Pro Leu Leu 
    1160                 1165                 1170             


Pro Asp  Ser Cys Glu Xaa Gly  Xaa Gly Leu Ala Arg  Ile Glu Ala 
    1175                 1180                 1185             


Xaa Gln  Ala Pro Gly Ala Pro  Gln Lys Asn Cys Lys  Ala Val Pro 
    1190                 1195                 1200             


Ser Phe  Asp Ser Leu His Pro  Val Xaa Asn Pro Ile  Xaa Ser Ser 
    1205                 1210                 1215             


Arg Lys  Leu Glu Glu Met Asp  Ser Lys Glu Gln Phe  Ser Ser Phe 
    1220                 1225                 1230             


Ser Cys  Glu Asp Gln Lys Glu  Val Arg Ala Met Ser  Gln Asp Ser 
    1235                 1240                 1245             


Asn Ser  Asn Ala Ala Pro Gly  Lys Ser Pro Gly Asp  Leu Xaa Xaa 
    1250                 1255                 1260             


Ser Arg  Xaa Pro Arg Phe Ser  Ser Pro Asn Val Ile  Ser Phe Gly 
    1265                 1270                 1275             


Pro Glu  Gln Xaa Gly Arg Ala  Leu Gly Asp Gln Ser  Asn Val Xaa 
    1280                 1285                 1290             


Gly Gln  Gly Lys Lys Leu Phe  Gly Ser Gly Asn Val  Ala Ala Xaa 
    1295                 1300                 1305             


Leu Gln  Arg Pro Arg Pro Ala  Asp Pro Met Pro Leu  Pro Ala Glu 
    1310                 1315                 1320             


Ile Pro  Pro Val Phe Pro Ser  Gly Lys Leu Gly Pro  Ser Xaa Asn 
    1325                 1330                 1335             


Ser Met  Ser Gly Gly Val Gln  Xaa Pro Arg Glu Asp  Trp Ala Pro 
    1340                 1345                 1350             


Lys Pro  His Ala Phe Val Gly  Ser Val Lys Asn Glu  Lys Xaa Phe 
    1355                 1360                 1365             


Val Gly  Gly Pro Leu Lys Ala  Asn Ala Glu Asn Arg  Lys Ala Xaa 
    1370                 1375                 1380             


Gly His  Ser Pro Leu Glu Leu  Val Gly His Leu Glu  Gly Met Pro 
    1385                 1390                 1395             


Phe Val  Met Asp Leu Pro Phe  Trp Lys Leu Pro Arg  Glu Pro Gly 
    1400                 1405                 1410             


Lys Gly  Leu Ser Glu Pro Leu  Glu Pro Ser Ser Leu  Pro Ser Gln 
    1415                 1420                 1425             


Leu Ser  Ile Lys Gln Ala Phe  Tyr Gly Lys Leu Ser  Lys Leu Gln 
    1430                 1435                 1440             


Leu Ser  Ser Xaa Ser Phe Asn  Tyr Ser Ser Ser Ser  Pro Xaa Phe 
    1445                 1450                 1455             


Pro Lys  Gly Leu Ala Gly Ser  Val Val Gln Leu Ser  His Lys Ala 
    1460                 1465                 1470             


Asn Phe  Gly Ala Ser His Ser  Ala Ser Leu Ser Leu  Gln Met Phe 
    1475                 1480                 1485             


Xaa Asp  Ser Ser Xaa Val Glu  Ser Ile Ser Leu Gln  Cys Ala Cys 
    1490                 1495                 1500             


Ser Leu  Lys Ala Met Ile Met  Cys Gln Gly Cys Gly  Ala Phe Cys 
    1505                 1510                 1515             


His Asp  Asp Cys Ile Gly Pro  Ser Lys Leu Cys Val  Leu Cys Leu 
    1520                 1525                 1530             


Val Val  Arg 
    1535     


<210> 3439
<211> 1541
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1184)..(1184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1221)..(1221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1267)..(1268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1287)..(1287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1298)..(1298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1313)..(1313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1342)..(1342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1372)..(1372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1388)..(1388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1452)..(1452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1462)..(1462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1494)..(1494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1498)..(1498)
<223> Selenocysteine

<400> 3439
Met Lys Asp Lys Gln Lys Lys Lys Lys Glu Arg Xaa Trp Ala Glu Ala 
1               5                   10                  15      


Ala Arg Leu Val Leu Glu Asn Tyr Ser Asp Ala Pro Met Xaa Pro Lys 
            20                  25                  30          


Gln Ile Leu Gln Val Ile Glu Ala Glu Gly Leu Lys Glu Met Arg Ser 
        35                  40                  45              


Gly Xaa Ser Pro Leu Ala Cys Leu Asn Ala Met Leu His Ser Asn Ser 
    50                  55                  60                  


Arg Gly Gly Glu Gly Leu Phe Tyr Lys Leu Pro Gly Arg Ile Ser Leu 
65                  70                  75                  80  


Phe Xaa Leu Lys Lys Asp Ala Leu Gln Trp Ser Arg His Pro Ala Xaa 
                85                  90                  95      


Val Glu Gly Glu Glu Pro Glu Asp Xaa Ala Asp Val Glu Ser Cys Gly 
            100                 105                 110         


Ser Asn Glu Ala Ser Xaa Val Ser Gly Glu Asn Asp Val Ser Leu Asp 
        115                 120                 125             


Glu Xaa Ser Ser Asn Ala Ser Cys Ser Xaa Glu Ser Gln Ser Arg Pro 
    130                 135                 140                 


Leu Ser Asn Pro Arg Asp Ser Tyr Arg Ala Ser Ser Gln Ala Asn Lys 
145                 150                 155                 160 


Gln Lys Lys Lys Xaa Gly Val Met Leu Pro Arg Val Val Leu Xaa Pro 
                165                 170                 175     


Leu Lys Val Asn Gly Ala His Val Glu Ser Ala Ser Gly Phe Ser Gly 
            180                 185                 190         


Cys His Ala Asp Gly Glu Ser Gly Ser Pro Ser Ser Ser Ser Ser Gly 
        195                 200                 205             


Ser Leu Ala Leu Gly Ser Ala Ala Ile Arg Gly Gln Ala Glu Val Xaa 
    210                 215                 220                 


Gln Asp Pro Ala Pro Leu Leu Arg Gly Phe Arg Lys Pro Ala Xaa Gly 
225                 230                 235                 240 


Gln Met Lys Arg Asn Arg Gly Glu Glu Ile Asp Phe Glu Xaa Pro Gly 
                245                 250                 255     


Ser Ile Leu Val Asn Xaa Asn Leu Arg Ala Leu Ile Asn Ser Arg Xaa 
            260                 265                 270         


Phe His Ala Leu Pro Ser His Phe Gln Gln Gln Leu Leu Phe Leu Leu 
        275                 280                 285             


Pro Glu Val Asp Arg Gln Val Gly Xaa Asp Gly Leu Leu Arg Leu Ser 
    290                 295                 300                 


Ser Ser Ala Leu Asn Asn Glu Phe Phe Xaa His Ala Ala Gln Ser Trp 
305                 310                 315                 320 


Arg Glu Arg Leu Ala Asp Gly Glu Phe Xaa His Glu Met Gln Val Arg 
                325                 330                 335     


Ile Arg Gln Glu Met Glu Lys Glu Lys Lys Val Glu Gln Trp Lys Glu 
            340                 345                 350         


Lys Phe Phe Glu Asp Tyr Tyr Gly Gln Lys Leu Gly Leu Xaa Lys Glu 
        355                 360                 365             


Glu Ser Leu Gln Gln Asn Val Gly Gln Glu Glu Ala Glu Ile Lys Ser 
    370                 375                 380                 


Gly Leu Cys Val Pro Gly Glu Ser Val Arg Ile Gln Arg Gly Pro Ala 
385                 390                 395                 400 


Xaa Arg Gln Arg Asp Gly His Phe Lys Lys Arg Ser Arg Pro Asp Leu 
                405                 410                 415     


Arg Xaa Arg Ala Arg Arg Asn Leu Tyr Lys Lys Gln Glu Ser Glu Gln 
            420                 425                 430         


Ala Gly Val Ala Lys Asp Ala Lys Ser Val Ala Ser Asp Val Pro Leu 
        435                 440                 445             


Tyr Lys Asp Gly Glu Ala Lys Xaa Asp Pro Ala Gly Leu Ser Ser Pro 
    450                 455                 460                 


His Leu Pro Gly Xaa Ser Ser Ala Ala Pro Asp Leu Glu Gly Pro Glu 
465                 470                 475                 480 


Phe Pro Val Glu Ser Val Ala Ser Arg Ile Gln Ala Glu Pro Asp Asn 
                485                 490                 495     


Leu Ala Arg Ala Ser Ala Ser Pro Asp Arg Ile Pro Ser Leu Pro Gln 
            500                 505                 510         


Glu Xaa Val Asp Gln Glu Pro Lys Asp Gln Lys Arg Lys Ser Phe Glu 
        515                 520                 525             


Gln Ala Ala Ser Ala Ser Phe Pro Glu Lys Lys Pro Arg Leu Glu Asp 
    530                 535                 540                 


Arg Gln Ser Phe Arg Asn Xaa Ile Glu Ser Val His Xaa Glu Lys Pro 
545                 550                 555                 560 


Gln Pro Xaa Lys Glu Glu Pro Lys Val Pro Pro Ile Arg Ile Gln Leu 
                565                 570                 575     


Ser Arg Ile Lys Pro Pro Trp Val Val Lys Gly Gln Pro Xaa Tyr Gln 
            580                 585                 590         


Ile Cys Pro Arg Ile Ile Pro Xaa Xaa Glu Ser Ser Cys Arg Gly Trp 
        595                 600                 605             


Xaa Gly Ala Arg Xaa Leu Ala Asp Ile Lys Ala Arg Ala Leu Gln Val 
    610                 615                 620                 


Arg Gly Ala Arg Gly His His Cys His Arg Glu Ala Ala Xaa Xaa Ala 
625                 630                 635                 640 


Ile Gly Gly Gly Gly Gly Pro Gly Gly Gly Gly Gly Gly Ala Xaa Asp 
                645                 650                 655     


Glu Gly Gly Gly Arg Gly Ser Ser Ser Gly Asp Gly Gly Glu Ala Cys 
            660                 665                 670         


Gly His Pro Glu Pro Arg Gly Gly Pro Ser Xaa Pro Gly Lys Cys Xaa 
        675                 680                 685             


Ser Asp Leu Gln Arg Xaa Gln Leu Leu Pro Pro Tyr Pro Leu Asn Gly 
    690                 695                 700                 


Glu His Xaa Gln Ala Gly Xaa Ala Met Ser Arg Ala Arg Arg Glu Asp 
705                 710                 715                 720 


Leu Pro Ser Leu Arg Lys Glu Glu Ser Cys Leu Leu Gln Arg Ala Xaa 
                725                 730                 735     


Val Gly Leu Xaa Asp Gly Leu Gly Asp Ala Ser Gln Leu Pro Val Ala 
            740                 745                 750         


Pro Xaa Gly Asp Gln Pro Cys Gln Ala Leu Pro Leu Leu Ser Ser Gln 
        755                 760                 765             


Xaa Ser Val Ala Glu Arg Leu Val Glu Gln Pro Gln Leu His Pro Asp 
    770                 775                 780                 


Val Arg Xaa Glu Cys Glu Ser Gly Xaa Xaa Ser Trp Glu Ser Asp Asp 
785                 790                 795                 800 


Glu Glu Gln Gly Pro Xaa Val Pro Ala Asp Asn Gly Pro Ile Pro Ser 
                805                 810                 815     


Leu Val Gly Asp Asp Xaa Leu Glu Lys Gly Xaa Gly Gln Ala Leu Asp 
            820                 825                 830         


Ser His Pro Xaa Met Lys Asp Pro Val Asn Val Xaa Pro Ser Ser Xaa 
        835                 840                 845             


Pro Glu Ser Ser Pro Xaa Asp Cys Leu Gln Asn Arg Ala Phe Asp Asp 
    850                 855                 860                 


Glu Leu Gly Leu Gly Gly Ser Cys Pro Pro Met Arg Glu Ser Asp Xaa 
865                 870                 875                 880 


Arg Gln Glu Asn Leu Lys Xaa Lys Ala Leu Val Ser Asn Ser Ser Leu 
                885                 890                 895     


His Trp Ile Pro Ile Pro Ser Asn Asp Glu Val Val Lys Gln Pro Lys 
            900                 905                 910         


Pro Glu Ser Arg Glu His Ile Pro Ser Val Glu Pro Gln Val Gly Glu 
        915                 920                 925             


Glu Trp Glu Lys Ala Ala Pro Xaa Pro Pro Ala Leu Pro Gly Asp Leu 
    930                 935                 940                 


Xaa Ala Glu Glu Gly Leu Asp Pro Leu Asp Ser Leu Xaa Ser Leu Trp 
945                 950                 955                 960 


Xaa Val Pro Ser Arg Gly Gly Ser Asp Ser Asn Gly Ser Tyr Cys Gln 
                965                 970                 975     


Gln Val Asp Ile Glu Lys Leu Lys Ile Asn Gly Asp Ser Glu Ala Leu 
            980                 985                 990         


Ser Pro His Gly Glu Ser Xaa Asp  Xaa Ala Ser Asp Phe  Glu Gly His 
        995                 1000                 1005             


Leu Xaa  Glu Asp Ser Ser Glu  Ala Asp Xaa Arg Glu  Ala Ala Val 
    1010                 1015                 1020             


Xaa Lys  Gly Ser Ser Val Asp  Lys Asp Glu Lys Pro  Asn Trp Asn 
    1025                 1030                 1035             


Gln Ser  Ala Pro Leu Ser Lys  Val Asn Gly Asp Met  Arg Leu Val 
    1040                 1045                 1050             


Xaa Arg  Xaa Asp Gly Met Val  Ala Pro Gln Ser Trp  Val Ser Arg 
    1055                 1060                 1065             


Val Cys  Ala Val Arg Gln Lys  Ile Pro Asp Ser Leu  Leu Leu Ala 
    1070                 1075                 1080             


Ser Xaa  Glu Tyr Gln Pro Arg  Ala Val Cys Leu Ser  Met Pro Gly 
    1085                 1090                 1095             


Ser Ser  Val Glu Ala Xaa Asn  Pro Leu Val Met Gln  Leu Leu Gln 
    1100                 1105                 1110             


Gly Ser  Leu Pro Leu Glu Lys  Val Leu Pro Pro Ala  His Asp Asp 
    1115                 1120                 1125             


Ser Met  Ser Glu Ser Pro Gln  Val Pro Leu Xaa Lys  Asp Gln Ser 
    1130                 1135                 1140             


His Gly  Ser Leu Arg Met Gly  Ser Leu His Gly Leu  Gly Lys Asn 
    1145                 1150                 1155             


Ser Gly  Met Val Asp Gly Ser  Ser Pro Ser Ser Leu  Arg Ala Leu 
    1160                 1165                 1170             


Lys Glu  Pro Leu Leu Pro Asp  Ser Cys Glu Xaa Gly  Xaa Gly Leu 
    1175                 1180                 1185             


Ala Arg  Ile Glu Ala Xaa Gln  Ala Pro Gly Ala Pro  Gln Lys Asn 
    1190                 1195                 1200             


Cys Lys  Ala Val Pro Ser Phe  Asp Ser Leu His Pro  Val Xaa Asn 
    1205                 1210                 1215             


Pro Ile  Xaa Ser Ser Arg Lys  Leu Glu Glu Met Asp  Ser Lys Glu 
    1220                 1225                 1230             


Gln Phe  Ser Ser Phe Ser Cys  Glu Asp Gln Lys Glu  Val Arg Ala 
    1235                 1240                 1245             


Met Ser  Gln Asp Ser Asn Ser  Asn Ala Ala Pro Gly  Lys Ser Pro 
    1250                 1255                 1260             


Gly Asp  Leu Xaa Xaa Ser Arg  Xaa Pro Arg Phe Ser  Ser Pro Asn 
    1265                 1270                 1275             


Val Ile  Ser Phe Gly Pro Glu  Gln Xaa Gly Arg Ala  Leu Gly Asp 
    1280                 1285                 1290             


Gln Ser  Asn Val Xaa Gly Gln  Gly Lys Lys Leu Phe  Gly Ser Gly 
    1295                 1300                 1305             


Asn Val  Ala Ala Xaa Leu Gln  Arg Pro Arg Pro Ala  Asp Pro Met 
    1310                 1315                 1320             


Pro Leu  Pro Ala Glu Ile Pro  Pro Val Phe Pro Ser  Gly Lys Leu 
    1325                 1330                 1335             


Gly Pro  Ser Xaa Asn Ser Met  Ser Gly Gly Val Gln  Xaa Pro Arg 
    1340                 1345                 1350             


Glu Asp  Trp Ala Pro Lys Pro  His Ala Phe Val Gly  Ser Val Lys 
    1355                 1360                 1365             


Asn Glu  Lys Xaa Phe Val Gly  Gly Pro Leu Lys Ala  Asn Ala Glu 
    1370                 1375                 1380             


Asn Arg  Lys Ala Xaa Gly His  Ser Pro Leu Glu Leu  Val Gly His 
    1385                 1390                 1395             


Leu Glu  Gly Met Pro Phe Val  Met Asp Leu Pro Phe  Trp Lys Leu 
    1400                 1405                 1410             


Pro Arg  Glu Pro Gly Lys Gly  Leu Ser Glu Pro Leu  Glu Pro Ser 
    1415                 1420                 1425             


Ser Leu  Pro Ser Gln Leu Ser  Ile Lys Gln Ala Phe  Tyr Gly Lys 
    1430                 1435                 1440             


Leu Ser  Lys Leu Gln Leu Ser  Ser Xaa Ser Phe Asn  Tyr Ser Ser 
    1445                 1450                 1455             


Ser Ser  Pro Xaa Phe Pro Lys  Gly Leu Ala Gly Ser  Val Val Gln 
    1460                 1465                 1470             


Leu Ser  His Lys Ala Asn Phe  Gly Ala Ser His Ser  Ala Ser Leu 
    1475                 1480                 1485             


Ser Leu  Gln Met Phe Xaa Asp  Ser Ser Xaa Val Glu  Ser Ile Ser 
    1490                 1495                 1500             


Leu Gln  Cys Ala Cys Ser Leu  Lys Ala Met Ile Met  Cys Gln Gly 
    1505                 1510                 1515             


Cys Gly  Ala Phe Cys His Asp  Asp Cys Ile Gly Pro  Ser Lys Leu 
    1520                 1525                 1530             


Cys Val  Leu Cys Leu Val Val  Arg 
    1535                 1540     


<210> 3440
<211> 85
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<400> 3440
Met Lys Asp Lys Gln Lys Lys Lys Lys Glu Arg Xaa Trp Ala Glu Ala 
1               5                   10                  15      


Ala Arg Leu Val Leu Glu Asn Tyr Ser Asp Ala Pro Met Xaa Pro Lys 
            20                  25                  30          


Gln Ile Leu Gln Val Ile Glu Ala Glu Gly Leu Lys Glu Met Arg Ser 
        35                  40                  45              


Gly Xaa Ser Pro Leu Ala Cys Leu Asn Ala Met Leu His Ser Asn Ser 
    50                  55                  60                  


Arg Gly Gly Glu Gly Leu Phe Tyr Lys Leu Pro Gly Arg Ile Ser Leu 
65                  70                  75                  80  


Phe Xaa Leu Lys Val 
                85  


<210> 3441
<211> 57
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<400> 3441
Met Xaa Pro Lys Gln Ile Leu Gln Val Ile Glu Ala Glu Gly Leu Lys 
1               5                   10                  15      


Glu Met Arg Ser Gly Xaa Ser Pro Leu Ala Cys Leu Asn Ala Met Leu 
            20                  25                  30          


His Ser Asn Ser Arg Gly Gly Glu Gly Leu Phe Tyr Lys Leu Pro Gly 
        35                  40                  45              


Arg Ile Ser Leu Phe Xaa Leu Lys Arg 
    50                  55          


<210> 3442
<211> 74
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<400> 3442
Xaa Trp Ala Glu Ala Ala Arg Leu Val Leu Glu Asn Tyr Ser Asp Ala 
1               5                   10                  15      


Pro Met Xaa Pro Lys Gln Ile Leu Gln Val Ile Glu Ala Glu Gly Leu 
            20                  25                  30          


Lys Glu Met Arg Ser Gly Xaa Ser Pro Leu Ala Cys Leu Asn Ala Met 
        35                  40                  45              


Leu His Ser Asn Ser Arg Gly Gly Glu Gly Leu Phe Tyr Lys Leu Pro 
    50                  55                  60                  


Gly Arg Ile Ser Leu Phe Xaa Leu Lys Val 
65                  70                  


<210> 3443
<211> 918
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<400> 3443
Met Lys Arg Xaa Lys Cys Ala Asp Ile Asp Val Glu Xaa Pro Asp Ser 
1               5                   10                  15      


Ile Leu Val Asn Xaa Asn Leu Arg Ala Leu Ile Asn Lys His Xaa Phe 
            20                  25                  30          


Ser Val Leu Pro Gly Asp Cys Gln Gln Arg Leu Leu Leu Leu Leu Pro 
        35                  40                  45              


Glu Val Asp Arg Gln Val Gly Pro Asp Gly Leu Met Lys Leu Asn Gly 
    50                  55                  60                  


Ser Ala Leu Asn Asn Glu Phe Phe Xaa Ser Ala Ala Gln Gly Trp Lys 
65                  70                  75                  80  


Glu Arg Leu Ser Glu Gly Glu Phe Xaa Pro Glu Met Gln Val Arg Ile 
                85                  90                  95      


Arg Gln Glu Ile Glu Lys Glu Lys Lys Val Glu Pro Trp Lys Glu Gln 
            100                 105                 110         


Phe Phe Glu Ser Tyr Tyr Gly Gln Ser Ser Gly Leu Ser Leu Glu Asp 
        115                 120                 125             


Ser Lys Lys Leu Xaa Ala Ser Pro Ser Asp Pro Lys Val Lys Lys Xaa 
    130                 135                 140                 


Pro Ala Glu Gln Pro Lys Ser Met Pro Val Ser Glu Ala Ser Leu Ile 
145                 150                 155                 160 


Arg Ile Val Pro Val Val Ser Gln Ser Glu Cys Lys Glu Glu Ala Leu 
                165                 170                 175     


Gln Met Ser Ser Pro Gly Arg Lys Glu Glu Cys Glu Ser Gln Gly Glu 
            180                 185                 190         


Val Gln Pro Asn Phe Ser Xaa Ser Ser Glu Pro Leu Leu Ser Ser Ala 
        195                 200                 205             


Leu Asn Xaa His Glu Leu Ser Ser Ile Leu Pro Ile Lys Cys Pro Lys 
    210                 215                 220                 


Asp Glu Asp Leu Leu Glu Gln Lys Pro Val Xaa Ser Ala Glu Gln Glu 
225                 230                 235                 240 


Ser Glu Lys Asn His Leu Xaa Xaa Ala Ser Asn Tyr Asn Lys Ser Glu 
                245                 250                 255     


Ser Gln Glu Ser Leu Val Xaa Ser Pro Ser Lys Pro Lys Ser Pro Gly 
            260                 265                 270         


Val Glu Lys Pro Ile Val Lys Pro Xaa Ala Gly Ala Gly Pro Gln Glu 
        275                 280                 285             


Xaa Asn Met Lys Glu Pro Leu Ala Xaa Leu Val Asp Gln Ser Pro Glu 
    290                 295                 300                 


Ser Leu Lys Arg Lys Ser Ser Leu Xaa Gln Glu Glu Ala Pro Val Ser 
305                 310                 315                 320 


Trp Glu Lys Arg Pro Arg Val Xaa Glu Asn Arg Gln His Gln Gln Pro 
                325                 330                 335     


Phe Gln Val Ser Pro Gln Pro Phe Leu Asn Arg Gly Asp Arg Ile Gln 
            340                 345                 350         


Val Arg Lys Val Pro Pro Leu Lys Ile Pro Val Ser Arg Ile Ser Pro 
        355                 360                 365             


Met Pro Phe His Pro Ser Gln Val Ser Pro Arg Ala Arg Phe Pro Val 
    370                 375                 380                 


Ser Ile Xaa Ser Pro Asn Arg Xaa Gly Ala Arg Xaa Leu Ala Asp Ile 
385                 390                 395                 400 


Lys Ala Lys Ala Gln Leu Val Lys Ala Gln Arg Ala Ala Ala Ala Ala 
                405                 410                 415     


Ala Ala Ala Ala Ala Ala Ala Ala Ser Val Gly Gly Xaa Ile Pro Gly 
            420                 425                 430         


Pro Gly Pro Gly Gly Gly Gln Gly Pro Gly Glu Gly Gly Glu Gly Gln 
        435                 440                 445             


Xaa Ala Arg Gly Gly Ser Pro Gly Ser Asp Arg Val Ser Glu Xaa Gly 
    450                 455                 460                 


Lys Gly Pro Xaa Leu Glu Leu Ala Gly Xaa Gly Ser Arg Gly Gly Xaa 
465                 470                 475                 480 


Arg Glu Leu Leu Pro Cys Gly Pro Glu Xaa Gln Pro Gln Ser Glu Xaa 
                485                 490                 495     


Lys Xaa Xaa Pro Ser Gln Ala Gln Pro His Ser Val Ser Gly Ala Gln 
            500                 505                 510         


Leu Gln Gln Xaa Pro Pro Val Pro Pro Xaa Pro Ala Val Ser Gly Ala 
        515                 520                 525             


Cys Xaa Ser Val Pro Ser Pro Ala His Ile Glu Lys Leu Asp Asn Glu 
    530                 535                 540                 


Lys Leu Asn Pro Xaa Arg Ala Xaa Ala Xaa Val Ala Ser Val Ser His 
545                 550                 555                 560 


Pro Gln Gly Pro Ser Ser Cys Arg Gln Glu Lys Ala Pro Ser Pro Xaa 
                565                 570                 575     


Gly Phe Gln Leu Glu Asp Ile Ser Xaa Ser Gln Arg Phe Met Leu Gly 
            580                 585                 590         


Phe Ala Gly Arg Arg Xaa Ser Lys Pro Ala Met Ala Gly His Tyr Leu 
        595                 600                 605             


Leu Asn Ile Ser Xaa Tyr Gly Arg Gly Ser Glu Ser Phe Arg Arg Xaa 
    610                 615                 620                 


His Ser Val Asn Pro Glu Asp Arg Phe Cys Leu Ser Ser Pro Xaa Glu 
625                 630                 635                 640 


Ala Leu Lys Met Gly Tyr Xaa Asp Cys Lys Asn Ala Xaa Gly Glu Ser 
                645                 650                 655     


Ser Ser Ser Lys Glu Asp Asp Xaa Asp Glu Glu Ser Xaa Gly Asp Glu 
            660                 665                 670         


Gln Glu Ser Val Xaa Val Lys Glu Glu Pro Gln Val Ser Gln Ser Ala 
        675                 680                 685             


Gly Lys Gly Asp Xaa Ser Ser Gly Pro His Ser Arg Glu Xaa Leu Ser 
    690                 695                 700                 


Xaa Ser Asp Cys Leu Ala Ser Lys Asn Val Lys Ala Glu Ile Pro Leu 
705                 710                 715                 720 


Asn Glu Gln Xaa Xaa Leu Ser Lys Glu Asn Tyr Leu Phe Xaa Arg Gly 
                725                 730                 735     


Gln Xaa Phe Asp Glu Lys Xaa Leu Ala Arg Asp Leu Ile Gln Ala Ala 
            740                 745                 750         


Gln Lys Gln Met Ala His Ala Val Arg Gly Lys Ala Ile Arg Ser Ser 
        755                 760                 765             


Pro Glu Leu Phe Ser Ser Xaa Val Leu Pro Leu Pro Ala Asp Ser Pro 
    770                 775                 780                 


Xaa His Gln Pro Leu Leu Leu Pro Pro Leu Gln Xaa Pro Lys Leu Tyr 
785                 790                 795                 800 


Gly Ser Pro Xaa Gln Ile Gly Pro Ser Tyr Arg Gly Met Ile Asn Val 
                805                 810                 815     


Ser Xaa Ser Ser Asp Met Asp His Asn Ser Ala Val Pro Gly Ser Gln 
            820                 825                 830         


Val Ser Ser Asn Val Gly Asp Val Met Ser Phe Ser Val Xaa Val Xaa 
        835                 840                 845             


Xaa Ile Pro Ala Ser Gln Ala Met Asn Pro Ser Ser His Gly Gln Xaa 
    850                 855                 860                 


Ile Pro Val Gln Ala Phe Ser Glu Glu Asn Ser Ile Glu Gly Xaa Pro 
865                 870                 875                 880 


Ser Lys Cys Tyr Cys Arg Leu Lys Ala Met Ile Met Cys Lys Gly Cys 
                885                 890                 895     


Gly Ala Phe Cys His Asp Asp Cys Ile Gly Pro Ser Lys Leu Cys Val 
            900                 905                 910         


Ser Cys Leu Val Val Arg 
        915             


<210> 3444
<211> 1435
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (983)..(983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (996)..(996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1222)..(1222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1255)..(1255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1260)..(1260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1313)..(1313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1321)..(1321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1363)..(1363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1365)..(1366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1396)..(1396)
<223> Selenocysteine

<400> 3444
Met Arg Glu Lys Gly Arg Arg Lys Lys Gly Arg Xaa Trp Ala Glu Ala 
1               5                   10                  15      


Ala Lys Xaa Val Leu Glu Lys Tyr Pro Asn Xaa Pro Met Ser His Lys 
            20                  25                  30          


Glu Ile Leu Gln Val Ile Gln Arg Glu Gly Leu Lys Glu Ile Arg Ser 
        35                  40                  45              


Gly Xaa Ser Pro Leu Ala Cys Leu Asn Ala Met Leu His Xaa Asn Ser 
    50                  55                  60                  


Arg Gly Glu Glu Gly Ile Phe Tyr Lys Val Pro Gly Arg Met Gly Val 
65                  70                  75                  80  


Tyr Xaa Leu Lys Lys Asp Val Pro Asp Gly Val Lys Glu Leu Ser Glu 
                85                  90                  95      


Gly Ser Glu Glu Ser Ser Asp Gly Gln Ser Asp Ser Gln Ser Ser Glu 
            100                 105                 110         


Asn Ser Ser Ser Ser Ser Asp Gly Gly Ser Asn Lys Glu Gly Lys Lys 
        115                 120                 125             


Ser Arg Trp Lys Arg Lys Val Ser Ser Ser Ser Pro Gln Ser Gly Cys 
    130                 135                 140                 


Pro Ser Pro Xaa Ile Pro Ala Gly Lys Val Ile Ser Pro Ser Gln Lys 
145                 150                 155                 160 


His Ser Lys Lys Ala Leu Lys Gln Ala Leu Lys Gln Gln Gln Gln Lys 
                165                 170                 175     


Lys Gln Gln Gln Gln Cys Arg Pro Ser Ile Ser Ile Ser Ser Asn Gln 
            180                 185                 190         


His Leu Ser Leu Lys Xaa Val Lys Ala Ala Ser Asp Ser Val Pro Ala 
        195                 200                 205             


Lys Pro Ala Xaa Trp Glu Gly Lys Gln Ser Asp Gly Gln Xaa Gly Ser 
    210                 215                 220                 


Pro Gln Asn Ser Asn Ser Ser Phe Ser Ser Ser Val Lys Val Glu Asn 
225                 230                 235                 240 


Xaa Leu Leu Gly Leu Gly Lys Lys Ser Phe Gln Arg Ser Glu Arg Leu 
                245                 250                 255     


His Xaa Arg Gln Met Lys Arg Xaa Lys Cys Ala Asp Ile Asp Val Glu 
            260                 265                 270         


Xaa Pro Asp Ser Ile Leu Val Asn Xaa Asn Leu Arg Ala Leu Ile Asn 
        275                 280                 285             


Lys His Xaa Phe Ser Val Leu Pro Gly Asp Cys Gln Gln Arg Leu Leu 
    290                 295                 300                 


Leu Leu Leu Pro Glu Val Asp Arg Gln Val Gly Pro Asp Gly Leu Met 
305                 310                 315                 320 


Lys Leu Asn Gly Ser Ala Leu Asn Asn Glu Phe Phe Xaa Ser Ala Ala 
                325                 330                 335     


Gln Gly Trp Lys Glu Arg Leu Ser Glu Gly Glu Phe Xaa Pro Glu Met 
            340                 345                 350         


Gln Val Arg Ile Arg Gln Glu Ile Glu Lys Glu Lys Lys Val Glu Pro 
        355                 360                 365             


Trp Lys Glu Gln Phe Phe Glu Ser Tyr Tyr Gly Gln Ser Ser Gly Leu 
    370                 375                 380                 


Ser Leu Glu Asp Ser Lys Lys Leu Xaa Ala Ser Pro Ser Asp Pro Lys 
385                 390                 395                 400 


Val Lys Lys Xaa Pro Ala Glu Gln Pro Lys Ser Met Pro Val Ser Glu 
                405                 410                 415     


Ala Ser Leu Ile Arg Ile Val Pro Val Val Ser Gln Ser Glu Cys Lys 
            420                 425                 430         


Glu Glu Ala Leu Gln Met Ser Ser Pro Gly Arg Lys Glu Glu Cys Glu 
        435                 440                 445             


Ser Gln Gly Glu Val Gln Pro Asn Phe Ser Xaa Ser Ser Glu Pro Leu 
    450                 455                 460                 


Leu Ser Ser Ala Leu Asn Xaa His Glu Leu Ser Ser Ile Leu Pro Ile 
465                 470                 475                 480 


Lys Cys Pro Lys Asp Glu Asp Leu Leu Glu Gln Lys Pro Val Xaa Ser 
                485                 490                 495     


Ala Glu Gln Glu Ser Glu Lys Asn His Leu Xaa Xaa Ala Ser Asn Tyr 
            500                 505                 510         


Asn Lys Ser Glu Ser Gln Glu Ser Leu Val Xaa Ser Pro Ser Lys Pro 
        515                 520                 525             


Lys Ser Pro Gly Val Glu Lys Pro Ile Val Lys Pro Xaa Ala Gly Ala 
    530                 535                 540                 


Gly Pro Gln Glu Xaa Asn Met Lys Glu Pro Leu Ala Xaa Leu Val Asp 
545                 550                 555                 560 


Gln Ser Pro Glu Ser Leu Lys Arg Lys Ser Ser Leu Xaa Gln Glu Glu 
                565                 570                 575     


Ala Pro Val Ser Trp Glu Lys Arg Pro Arg Val Xaa Glu Asn Arg Gln 
            580                 585                 590         


His Gln Gln Pro Phe Gln Val Ser Pro Gln Pro Phe Leu Asn Arg Gly 
        595                 600                 605             


Asp Arg Ile Gln Val Arg Lys Val Pro Pro Leu Lys Ile Pro Val Ser 
    610                 615                 620                 


Arg Ile Ser Pro Met Pro Phe His Pro Ser Gln Val Ser Pro Arg Ala 
625                 630                 635                 640 


Arg Phe Pro Val Ser Ile Xaa Ser Pro Asn Arg Xaa Gly Ala Arg Xaa 
                645                 650                 655     


Leu Ala Asp Ile Lys Ala Lys Ala Gln Leu Val Lys Ala Gln Arg Ala 
            660                 665                 670         


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Val Gly Gly 
        675                 680                 685             


Xaa Ile Pro Gly Pro Gly Pro Gly Gly Gly Gln Gly Pro Gly Glu Gly 
    690                 695                 700                 


Gly Glu Gly Gln Xaa Ala Arg Gly Gly Ser Pro Gly Ser Asp Arg Val 
705                 710                 715                 720 


Ser Glu Xaa Gly Lys Gly Pro Xaa Leu Glu Leu Ala Gly Xaa Gly Ser 
                725                 730                 735     


Arg Gly Gly Xaa Arg Glu Leu Leu Pro Cys Gly Pro Glu Xaa Gln Pro 
            740                 745                 750         


Gln Ser Glu Xaa Lys Xaa Xaa Pro Ser Gln Ala Gln Pro His Ser Val 
        755                 760                 765             


Ser Gly Ala Gln Leu Gln Gln Xaa Pro Pro Val Pro Pro Xaa Pro Ala 
    770                 775                 780                 


Val Ser Gly Ala Cys Xaa Ser Val Pro Ser Pro Ala His Ile Glu Lys 
785                 790                 795                 800 


Leu Asp Asn Glu Lys Leu Asn Pro Xaa Arg Ala Xaa Ala Xaa Val Ala 
                805                 810                 815     


Ser Val Ser His Pro Gln Gly Pro Ser Ser Cys Arg Gln Glu Lys Ala 
            820                 825                 830         


Pro Ser Pro Xaa Gly Pro Ala Leu Ile Ser Gly Ala Ser Pro Val His 
        835                 840                 845             


Cys Ala Ala Asp Gly Xaa Val Glu Leu Lys Ala Gly Pro Ser Lys Asn 
    850                 855                 860                 


Ile Pro Asn Pro Ser Ala Ser Ser Lys Xaa Asp Ala Ser Val Pro Val 
865                 870                 875                 880 


Ala Val Xaa Pro Ser Pro Leu Xaa Ser Leu Leu Xaa Xaa Ala Xaa Leu 
                885                 890                 895     


Glu Lys Leu Pro Val Pro Gln Val Ser Ala Xaa Xaa Ala Pro Ala Gly 
            900                 905                 910         


Ser Ala Pro Pro Ser Ser Xaa Leu Pro Ala Ala Ser Ser Leu Lys Xaa 
        915                 920                 925             


Pro Gly Xaa Ser Leu Asn Met Asn Gly Pro Xaa Leu Arg Pro Xaa Ser 
    930                 935                 940                 


Ser Ile Pro Ala Asn Asn Pro Leu Val Xaa Gln Leu Leu Gln Gly Lys 
945                 950                 955                 960 


Asp Val Pro Met Glu Gln Ile Leu Pro Lys Pro Leu Xaa Lys Val Glu 
                965                 970                 975     


Met Lys Xaa Val Pro Leu Xaa Ala Lys Glu Glu Arg Gly Met Gly Ala 
            980                 985                 990         


Leu Ile Ala Xaa Asn Xaa Xaa Glu  Asn Ser Xaa Arg Glu  Glu Val Asn 
        995                 1000                 1005             


Glu Arg  Gln Ser His Pro Ala  Xaa Gln Gln Gln Leu  Gly Lys Xaa 
    1010                 1015                 1020             


Leu Gln  Ser Lys Gln Leu Pro  Gln Val Pro Arg Pro  Leu Gln Leu 
    1025                 1030                 1035             


Phe Ser  Ala Lys Glu Leu Arg  Asp Ser Ser Ile Asp  Xaa His Gln 
    1040                 1045                 1050             


Tyr His  Glu Gly Leu Ser Lys  Ala Xaa Gln Asp Gln  Ile Leu Gln 
    1055                 1060                 1065             


Xaa Leu  Ile Gln Arg Val Arg  Arg Gln Asn Leu Leu  Ser Val Val 
    1070                 1075                 1080             


Pro Pro  Ser Gln Phe Asn Phe  Ala His Ser Gly Phe  Gln Leu Glu 
    1085                 1090                 1095             


Asp Ile  Ser Xaa Ser Gln Arg  Phe Met Leu Gly Phe  Ala Gly Arg 
    1100                 1105                 1110             


Arg Xaa  Ser Lys Pro Ala Met  Ala Gly His Tyr Leu  Leu Asn Ile 
    1115                 1120                 1125             


Ser Xaa  Tyr Gly Arg Gly Ser  Glu Ser Phe Arg Arg  Xaa His Ser 
    1130                 1135                 1140             


Val Asn  Pro Glu Asp Arg Phe  Cys Leu Ser Ser Pro  Xaa Glu Ala 
    1145                 1150                 1155             


Leu Lys  Met Gly Tyr Xaa Asp  Cys Lys Asn Ala Xaa  Gly Glu Ser 
    1160                 1165                 1170             


Ser Ser  Ser Lys Glu Asp Asp  Xaa Asp Glu Glu Ser  Xaa Gly Asp 
    1175                 1180                 1185             


Glu Gln  Glu Ser Val Xaa Val  Lys Glu Glu Pro Gln  Val Ser Gln 
    1190                 1195                 1200             


Ser Ala  Gly Lys Gly Asp Xaa  Ser Ser Gly Pro His  Ser Arg Glu 
    1205                 1210                 1215             


Xaa Leu  Ser Xaa Ser Asp Cys  Leu Ala Ser Lys Asn  Val Lys Ala 
    1220                 1225                 1230             


Glu Ile  Pro Leu Asn Glu Gln  Xaa Xaa Leu Ser Lys  Glu Asn Tyr 
    1235                 1240                 1245             


Leu Phe  Xaa Arg Gly Gln Xaa  Phe Asp Glu Lys Xaa  Leu Ala Arg 
    1250                 1255                 1260             


Asp Leu  Ile Gln Ala Ala Gln  Lys Gln Met Ala His  Ala Val Arg 
    1265                 1270                 1275             


Gly Lys  Ala Ile Arg Ser Ser  Pro Glu Leu Phe Ser  Ser Xaa Val 
    1280                 1285                 1290             


Leu Pro  Leu Pro Ala Asp Ser  Pro Xaa His Gln Pro  Leu Leu Leu 
    1295                 1300                 1305             


Pro Pro  Leu Gln Xaa Pro Lys  Leu Tyr Gly Ser Pro  Xaa Gln Ile 
    1310                 1315                 1320             


Gly Pro  Ser Tyr Arg Gly Met  Ile Asn Val Ser Xaa  Ser Ser Asp 
    1325                 1330                 1335             


Met Asp  His Asn Ser Ala Val  Pro Gly Ser Gln Val  Ser Ser Asn 
    1340                 1345                 1350             


Val Gly  Asp Val Met Ser Phe  Ser Val Xaa Val Xaa  Xaa Ile Pro 
    1355                 1360                 1365             


Ala Ser  Gln Ala Met Asn Pro  Ser Ser His Gly Gln  Xaa Ile Pro 
    1370                 1375                 1380             


Val Gln  Ala Phe Ser Glu Glu  Asn Ser Ile Glu Gly  Xaa Pro Ser 
    1385                 1390                 1395             


Lys Cys  Tyr Cys Arg Leu Lys  Ala Met Ile Met Cys  Lys Gly Cys 
    1400                 1405                 1410             


Gly Ala  Phe Cys His Asp Asp  Cys Ile Gly Pro Ser  Lys Leu Cys 
    1415                 1420                 1425             


Val Ser  Cys Leu Val Val Arg  
    1430                 1435 


<210> 3445
<211> 1407
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1128)..(1128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1191)..(1191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1213)..(1214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1293)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1353)..(1353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1368)..(1368)
<223> Selenocysteine

<400> 3445
Met Ser His Lys Glu Ile Leu Gln Val Ile Gln Arg Glu Gly Leu Lys 
1               5                   10                  15      


Glu Ile Ser Ser Gly Xaa Ser Pro Leu Ala Cys Leu Asn Ala Met Leu 
            20                  25                  30          


His Xaa Asn Ser Arg Gly Glu Glu Gly Ile Phe Tyr Lys Val Pro Gly 
        35                  40                  45              


Arg Met Gly Val Tyr Xaa Leu Lys Lys Asp Val Pro Asp Gly Val Lys 
    50                  55                  60                  


Glu Leu Ser Glu Gly Ser Glu Glu Ser Ser Asp Gly Gln Ser Asp Ser 
65                  70                  75                  80  


Gln Ser Ser Glu Asn Ser Ser Ser Ser Ser Asp Gly Gly Ser Asn Lys 
                85                  90                  95      


Glu Gly Lys Lys Ser Arg Trp Lys Arg Lys Val Ser Ser Ser Ser Pro 
            100                 105                 110         


Gln Ser Gly Cys Pro Ser Pro Xaa Ile Pro Ala Gly Lys Val Ile Ser 
        115                 120                 125             


Pro Ser Gln Lys His Ser Lys Lys Ala Leu Lys Gln Ala Leu Lys Gln 
    130                 135                 140                 


Gln Gln Gln Lys Lys Gln Gln Gln Gln Cys Arg Pro Ser Ile Ser Ile 
145                 150                 155                 160 


Ser Ser Asn Gln His Leu Ser Leu Lys Xaa Val Lys Ala Ala Ser Asp 
                165                 170                 175     


Ser Val Pro Ala Lys Pro Ala Xaa Trp Glu Gly Lys Gln Ser Asp Gly 
            180                 185                 190         


Gln Xaa Gly Ser Pro Gln Asn Ser Asn Ser Ser Phe Ser Ser Ser Val 
        195                 200                 205             


Lys Val Glu Asn Xaa Leu Leu Gly Leu Gly Lys Lys Ser Phe Gln Arg 
    210                 215                 220                 


Ser Glu Arg Leu His Xaa Arg Gln Met Lys Arg Xaa Lys Cys Ala Asp 
225                 230                 235                 240 


Ile Asp Val Glu Xaa Pro Asp Ser Ile Leu Val Asn Xaa Asn Leu Arg 
                245                 250                 255     


Ala Leu Ile Asn Lys His Xaa Phe Ser Val Leu Pro Gly Asp Cys Gln 
            260                 265                 270         


Gln Arg Leu Leu Leu Leu Leu Pro Glu Val Asp Arg Gln Val Gly Pro 
        275                 280                 285             


Asp Gly Leu Met Lys Leu Asn Gly Ser Ala Leu Asn Asn Glu Phe Phe 
    290                 295                 300                 


Xaa Ser Ala Ala Gln Gly Trp Lys Glu Arg Leu Ser Glu Gly Glu Phe 
305                 310                 315                 320 


Xaa Pro Glu Met Gln Val Arg Ile Arg Gln Glu Ile Glu Lys Glu Lys 
                325                 330                 335     


Lys Val Glu Pro Trp Lys Glu Gln Phe Phe Glu Ser Tyr Tyr Gly Gln 
            340                 345                 350         


Ser Ser Gly Leu Ser Leu Glu Asp Ser Lys Lys Leu Xaa Ala Ser Pro 
        355                 360                 365             


Ser Asp Pro Lys Val Lys Lys Xaa Pro Ala Glu Gln Pro Lys Ser Met 
    370                 375                 380                 


Pro Val Ser Glu Ala Ser Leu Ile Arg Ile Val Pro Val Val Ser Gln 
385                 390                 395                 400 


Ser Glu Cys Lys Glu Glu Ala Leu Gln Met Ser Ser Pro Gly Arg Lys 
                405                 410                 415     


Glu Glu Cys Glu Ser Gln Gly Glu Val Gln Pro Asn Phe Ser Xaa Ser 
            420                 425                 430         


Ser Glu Pro Leu Leu Ser Ser Ala Leu Asn Xaa His Glu Leu Ser Ser 
        435                 440                 445             


Ile Leu Pro Ile Lys Cys Pro Lys Asp Glu Asp Leu Leu Glu Gln Lys 
    450                 455                 460                 


Pro Val Xaa Ser Ala Glu Gln Glu Ser Glu Lys Asn His Leu Xaa Xaa 
465                 470                 475                 480 


Ala Ser Asn Tyr Asn Lys Ser Glu Ser Gln Glu Ser Leu Val Xaa Ser 
                485                 490                 495     


Pro Ser Lys Pro Lys Ser Pro Gly Val Glu Lys Pro Ile Val Lys Pro 
            500                 505                 510         


Xaa Ala Gly Ala Gly Pro Gln Glu Xaa Asn Met Lys Glu Pro Leu Ala 
        515                 520                 525             


Xaa Leu Val Asp Gln Ser Pro Glu Ser Leu Lys Arg Lys Ser Ser Leu 
    530                 535                 540                 


Xaa Gln Glu Glu Ala Pro Val Ser Trp Glu Lys Arg Pro Arg Val Xaa 
545                 550                 555                 560 


Glu Asn Arg Gln His Gln Gln Pro Phe Gln Val Ser Pro Gln Pro Phe 
                565                 570                 575     


Leu Asn Arg Gly Asp Arg Ile Gln Val Arg Lys Val Pro Pro Leu Lys 
            580                 585                 590         


Ile Pro Val Ser Arg Ile Ser Pro Met Pro Phe His Pro Ser Gln Val 
        595                 600                 605             


Ser Pro Arg Ala Arg Phe Pro Val Ser Ile Xaa Ser Pro Asn Arg Xaa 
    610                 615                 620                 


Gly Ala Arg Xaa Leu Ala Asp Ile Lys Ala Lys Ala Gln Leu Val Lys 
625                 630                 635                 640 


Ala Gln Arg Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                645                 650                 655     


Ser Val Gly Gly Xaa Ile Pro Gly Pro Gly Pro Gly Gly Gly Gln Gly 
            660                 665                 670         


Pro Gly Glu Gly Gly Glu Gly Gln Xaa Ala Arg Gly Gly Ser Pro Gly 
        675                 680                 685             


Ser Asp Arg Val Ser Glu Xaa Gly Lys Gly Pro Xaa Leu Glu Leu Ala 
    690                 695                 700                 


Gly Xaa Gly Ser Arg Gly Gly Xaa Arg Glu Leu Leu Pro Cys Gly Pro 
705                 710                 715                 720 


Glu Xaa Gln Pro Gln Ser Glu Xaa Lys Xaa Xaa Pro Ser Gln Ala Gln 
                725                 730                 735     


Pro His Ser Val Ser Gly Ala Gln Leu Gln Gln Xaa Pro Pro Val Pro 
            740                 745                 750         


Pro Xaa Pro Ala Val Ser Gly Ala Cys Xaa Ser Val Pro Ser Pro Ala 
        755                 760                 765             


His Ile Glu Lys Leu Asp Asn Glu Lys Leu Asn Pro Xaa Arg Ala Xaa 
    770                 775                 780                 


Ala Xaa Val Ala Ser Val Ser His Pro Gln Gly Pro Ser Ser Cys Arg 
785                 790                 795                 800 


Gln Glu Lys Ala Pro Ser Pro Xaa Gly Pro Ala Leu Ile Ser Gly Ala 
                805                 810                 815     


Ser Pro Val His Cys Ala Ala Asp Gly Xaa Val Glu Leu Lys Ala Gly 
            820                 825                 830         


Pro Ser Lys Asn Ile Pro Asn Pro Ser Ala Ser Ser Lys Xaa Asp Ala 
        835                 840                 845             


Ser Val Pro Val Ala Val Xaa Pro Ser Pro Leu Xaa Ser Leu Leu Xaa 
    850                 855                 860                 


Xaa Ala Xaa Leu Glu Lys Leu Pro Val Pro Gln Val Ser Ala Xaa Xaa 
865                 870                 875                 880 


Ala Pro Ala Gly Ser Ala Pro Pro Ser Ser Xaa Leu Pro Ala Ala Ser 
                885                 890                 895     


Ser Leu Lys Xaa Pro Gly Xaa Ser Leu Asn Met Asn Gly Pro Xaa Leu 
            900                 905                 910         


Arg Pro Xaa Ser Ser Ile Pro Ala Asn Asn Pro Leu Val Xaa Gln Leu 
        915                 920                 925             


Leu Gln Gly Lys Asp Val Pro Met Glu Gln Ile Leu Pro Lys Pro Leu 
    930                 935                 940                 


Xaa Lys Val Glu Met Lys Xaa Val Pro Leu Xaa Ala Lys Glu Glu Arg 
945                 950                 955                 960 


Gly Met Gly Ala Leu Ile Ala Xaa Asn Xaa Xaa Glu Asn Ser Xaa Arg 
                965                 970                 975     


Glu Glu Val Asn Glu Arg Gln Ser His Pro Ala Xaa Gln Gln Gln Leu 
            980                 985                 990         


Gly Lys Xaa Leu Gln Ser Lys Gln  Leu Pro Gln Val Pro  Arg Pro Leu 
        995                 1000                 1005             


Gln Leu  Phe Ser Ala Lys Glu  Leu Arg Asp Ser Ser  Ile Asp Xaa 
    1010                 1015                 1020             


His Gln  Tyr His Glu Gly Leu  Ser Lys Ala Xaa Gln  Asp Gln Ile 
    1025                 1030                 1035             


Leu Gln  Xaa Leu Ile Gln Arg  Val Arg Arg Gln Asn  Leu Leu Ser 
    1040                 1045                 1050             


Val Val  Pro Pro Ser Gln Phe  Asn Phe Ala His Ser  Gly Phe Gln 
    1055                 1060                 1065             


Leu Glu  Asp Ile Ser Xaa Ser  Gln Arg Phe Met Leu  Gly Phe Ala 
    1070                 1075                 1080             


Gly Arg  Arg Xaa Ser Lys Pro  Ala Met Ala Gly His  Tyr Leu Leu 
    1085                 1090                 1095             


Asn Ile  Ser Xaa Tyr Gly Arg  Gly Ser Glu Ser Phe  Arg Arg Xaa 
    1100                 1105                 1110             


His Ser  Val Asn Pro Glu Asp  Arg Phe Cys Leu Ser  Ser Pro Xaa 
    1115                 1120                 1125             


Glu Ala  Leu Lys Met Gly Tyr  Xaa Asp Cys Lys Asn  Ala Xaa Gly 
    1130                 1135                 1140             


Glu Ser  Ser Ser Ser Lys Glu  Asp Asp Xaa Asp Glu  Glu Ser Xaa 
    1145                 1150                 1155             


Gly Asp  Glu Gln Glu Ser Val  Xaa Val Lys Glu Glu  Pro Gln Val 
    1160                 1165                 1170             


Ser Gln  Ser Ala Gly Lys Gly  Asp Xaa Ser Ser Gly  Pro His Ser 
    1175                 1180                 1185             


Arg Glu  Xaa Leu Ser Xaa Ser  Asp Cys Leu Ala Ser  Lys Asn Val 
    1190                 1195                 1200             


Lys Ala  Glu Ile Pro Leu Asn  Glu Gln Xaa Xaa Leu  Ser Lys Glu 
    1205                 1210                 1215             


Asn Tyr  Leu Phe Xaa Arg Gly  Gln Xaa Phe Asp Glu  Lys Xaa Leu 
    1220                 1225                 1230             


Ala Arg  Asp Leu Ile Gln Ala  Ala Gln Lys Gln Met  Ala His Ala 
    1235                 1240                 1245             


Val Arg  Gly Lys Ala Ile Arg  Ser Ser Pro Glu Leu  Phe Ser Ser 
    1250                 1255                 1260             


Xaa Val  Leu Pro Leu Pro Ala  Asp Ser Pro Xaa His  Gln Pro Leu 
    1265                 1270                 1275             


Leu Leu  Pro Pro Leu Gln Xaa  Pro Lys Leu Tyr Gly  Ser Pro Xaa 
    1280                 1285                 1290             


Gln Ile  Gly Pro Ser Tyr Arg  Gly Met Ile Asn Val  Ser Xaa Ser 
    1295                 1300                 1305             


Ser Asp  Met Asp His Asn Ser  Ala Val Pro Gly Ser  Gln Val Ser 
    1310                 1315                 1320             


Ser Asn  Val Gly Asp Val Met  Ser Phe Ser Val Xaa  Val Xaa Xaa 
    1325                 1330                 1335             


Ile Pro  Ala Ser Gln Ala Met  Asn Pro Ser Ser His  Gly Gln Xaa 
    1340                 1345                 1350             


Ile Pro  Val Gln Ala Phe Ser  Glu Glu Asn Ser Ile  Glu Gly Xaa 
    1355                 1360                 1365             


Pro Ser  Lys Cys Tyr Cys Arg  Leu Lys Ala Met Ile  Met Cys Lys 
    1370                 1375                 1380             


Gly Cys  Gly Ala Phe Cys His  Asp Asp Cys Ile Gly  Pro Ser Lys 
    1385                 1390                 1395             


Leu Cys  Val Ser Cys Leu Val  Val Arg 
    1400                 1405         


<210> 3446
<211> 148
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 3446
Met Ala Ala Ser Ala Leu Arg Gly Leu Pro Val Ala Gly Gly Gly Glu 
1               5                   10                  15      


Ser Ser Glu Ser Glu Asp Asp Gly Trp Glu Ile Gly Tyr Leu Asp Arg 
            20                  25                  30          


Xaa Ser Gln Lys Leu Lys Arg Leu Leu Pro Ile Glu Glu Lys Lys Glu 
        35                  40                  45              


Lys Phe Lys Lys Ala Met Xaa Ile Gly Asp Val Ser Leu Val Gln Glu 
    50                  55                  60                  


Leu Leu Asp Ser Gly Ile Ser Val Asp Ser Asn Phe Gln Tyr Gly Trp 
65                  70                  75                  80  


Xaa Pro Leu Met Tyr Ala Ala Ser Val Ala Asn Ala Glu Leu Val Arg 
                85                  90                  95      


Val Leu Leu Asp Arg Gly Ala Asn Ala Ser Phe Glu Lys Asp Lys Gln 
            100                 105                 110         


Ser Ile Leu Ile Xaa Ala Cys Ser Ala His Gly Ser Glu Glu Gln Ile 
        115                 120                 125             


Leu Lys Cys Val Glu Leu Leu Leu Ser Arg Asn Ala Asp Pro Asn Val 
    130                 135                 140                 


Ala Cys Arg Leu 
145             


<210> 3447
<211> 475
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<400> 3447
Met Ala Ala Ser Ala Leu Arg Gly Leu Pro Val Ala Gly Gly Gly Glu 
1               5                   10                  15      


Ser Ser Glu Ser Glu Asp Asp Gly Trp Glu Ile Gly Tyr Leu Asp Arg 
            20                  25                  30          


Xaa Ser Gln Lys Leu Lys Arg Leu Leu Pro Ile Glu Glu Lys Lys Glu 
        35                  40                  45              


Lys Phe Lys Lys Ala Met Xaa Ile Gly Asp Val Ser Leu Val Gln Glu 
    50                  55                  60                  


Leu Leu Asp Ser Gly Ile Ser Val Asp Ser Asn Phe Gln Tyr Gly Trp 
65                  70                  75                  80  


Xaa Pro Leu Met Tyr Ala Ala Ser Val Ala Asn Ala Glu Leu Val Arg 
                85                  90                  95      


Val Leu Leu Asp Arg Gly Ala Asn Ala Ser Phe Glu Lys Asp Lys Gln 
            100                 105                 110         


Ser Ile Leu Ile Xaa Ala Cys Ser Ala His Gly Ser Glu Glu Gln Ile 
        115                 120                 125             


Leu Lys Cys Val Glu Leu Leu Leu Ser Arg Asn Ala Asp Pro Asn Val 
    130                 135                 140                 


Ala Cys Arg Arg Leu Met Xaa Pro Ile Met Tyr Ala Ala Arg Asp Gly 
145                 150                 155                 160 


His Xaa Gln Val Val Ala Leu Leu Val Ala His Gly Ala Glu Val Asn 
                165                 170                 175     


Xaa Gln Asp Glu Asn Gly Tyr Xaa Ala Leu Xaa Trp Ala Ala Arg Gln 
            180                 185                 190         


Gly His Lys Asn Ile Val Leu Lys Leu Leu Glu Leu Gly Ala Asn Lys 
        195                 200                 205             


Met Leu Gln Xaa Lys Asp Gly Lys Met Pro Ser Glu Ile Ala Lys Arg 
    210                 215                 220                 


Asn Lys His His Glu Ile Phe Asn Leu Leu Ser Phe Xaa Leu Asn Pro 
225                 230                 235                 240 


Leu Glu Gly Lys Leu Gln Gln Leu Xaa Lys Glu Asp Xaa Ile Cys Lys 
                245                 250                 255     


Ile Leu Xaa Xaa Asp Ser Asp Arg Glu Lys Asp His Ile Phe Ser Ser 
            260                 265                 270         


Tyr Xaa Ala Phe Gly Asp Leu Glu Val Phe Leu His Gly Leu Gly Leu 
        275                 280                 285             


Glu His Met Xaa Asp Leu Leu Lys Glu Arg Asp Ile Xaa Leu Arg His 
    290                 295                 300                 


Leu Leu Xaa Met Arg Glu Asp Glu Phe Xaa Lys Asn Gly Ile Xaa Ser 
305                 310                 315                 320 


Lys Asp Gln Gln Lys Ile Leu Ala Ala Leu Lys Glu Leu Gln Val Glu 
                325                 330                 335     


Glu Ile Gln Phe Gly Glu Leu Ser Glu Glu Xaa Lys Leu Glu Ile Ser 
            340                 345                 350         


Gly Asp Glu Phe Leu Asn Phe Leu Leu Lys Leu Asn Lys Gln Cys Gly 
        355                 360                 365             


His Leu Ile Xaa Ala Val Gln Asn Val Ile Xaa Glu Leu Pro Val Asn 
    370                 375                 380                 


Ser Gln Lys Ile Xaa Leu Glu Trp Ala Ser Pro Gln Asn Phe Xaa Ser 
385                 390                 395                 400 


Val Cys Glu Glu Leu Val Asn Asn Val Glu Asp Leu Ser Glu Lys Val 
                405                 410                 415     


Cys Lys Leu Lys Asp Leu Ile Gln Lys Leu Gln Asn Glu Arg Glu Asn 
            420                 425                 430         


Asp Pro Xaa His Ile Gln Leu Arg Glu Glu Val Ser Xaa Trp Asn Ser 
        435                 440                 445             


Arg Ile Leu Lys Arg Xaa Ala Ile Xaa Ile Cys Gly Phe Gly Phe Leu 
    450                 455                 460                 


Leu Phe Ile Cys Lys Leu Xaa Phe Gln Arg Lys 
465                 470                 475 


<210> 3448
<211> 45
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<400> 3448
Met Xaa Ile Gly Asp Val Ser Leu Val Gln Glu Leu Leu Asp Ser Gly 
1               5                   10                  15      


Ile Ser Val Asp Ser Asn Phe Gln Tyr Gly Trp Xaa Pro Leu Met Tyr 
            20                  25                  30          


Ala Ala Ser Val Ala Asn Ala Glu Leu Val Arg Val Leu 
        35                  40                  45  


<210> 3449
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(70)
<223> Selenocysteine

<400> 3449
Met Glu Asp Ser His Lys Ser Xaa Xaa Ser Glu Xaa Ala Pro Gln Pro 
1               5                   10                  15      


Gly Ser Ala Val Gln Gly Ala His Ile Ser His Ile Ala Gln Gln Gly 
            20                  25                  30          


Leu Xaa Leu Ser Pro Arg Leu Val Cys Ser Ser Val Asn Ile Ala His 
        35                  40                  45              


Cys Ser Leu Asp Leu Leu Cys Ser Ser Asn Pro Pro Ala Ser Ala Pro 
    50                  55                  60                  


Gln Val Ala Gly Xaa Xaa Gly Ile Ile Phe Ile Arg Lys 
65                  70                  75          


<210> 3450
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<400> 3450
Met Glu Asp Ser His Lys Ser Xaa Xaa Ser Glu Xaa Ala Pro Gln Pro 
1               5                   10                  15      


Gly Ser Ala Val Gln Gly Ala His Ile Ser His Ile Ala Gln Gln Leu 
            20                  25                  30          


Pro Leu Pro Gln Met Glu Pro Tyr Ser Trp Gln Val Gln Ala Gln Met 
        35                  40                  45              


Glu Tyr Arg Asp Phe Arg His 
    50                  55  


<210> 3451
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<400> 3451
Met Glu Asp Ser His Lys Ser Xaa Xaa Ser Glu Xaa Ala Pro Gln Pro 
1               5                   10                  15      


Gly Ser Ala Val Gln Gly Ala His Ile Ser His Ile Ala Gln Gln Val 
            20                  25                  30          


Ser Ser Leu Ser Glu Ser Glu Glu Ser Gln Asp Ser Ser Asp Ser Ile 
        35                  40                  45              


Gly Ser Ser Gln Lys Ala His Gly Ile Leu Ala Arg Arg Pro Ser Tyr 
    50                  55                  60                  


Arg Lys Ile Leu Lys Asp Leu Ser Ser Glu Asp Xaa Arg Gly Arg Lys 
65                  70                  75                  80  


Gly Asp Gly Glu Asn Ser Gly Val Ser Ala Ala Val Xaa Ser Met Ser 
                85                  90                  95      


Val Pro Xaa Pro Ile Tyr Gln Xaa Ser Ser Gly Gln Tyr Ile Ala Ile 
            100                 105                 110         


Ala Pro Asn Gly Ala Leu Gln Leu Ala Ser Pro Gly Xaa Asp Gly Val 
        115                 120                 125             


Gln Gly Leu Gln Xaa Leu Xaa Met Xaa Asn Ser Gly Ser Xaa Gln Gln 
    130                 135                 140                 


Gly Xaa Xaa Ile Leu Gln Tyr Ala Gln Xaa Ser Asp Gly Gln Gln Ile 
145                 150                 155                 160 


Leu Val Pro Ser Asn Gln Val Val Val Gln 
                165                 170 


<210> 3452
<211> 200
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<400> 3452
Met Glu Asp Ser His Lys Ser Xaa Xaa Ser Glu Xaa Ala Pro Gln Pro 
1               5                   10                  15      


Gly Ser Ala Val Gln Gly Ala His Ile Ser His Ile Ala Gln Gln Val 
            20                  25                  30          


Ser Ser Leu Ser Glu Ser Glu Glu Ser Gln Asp Ser Ser Asp Ser Ile 
        35                  40                  45              


Gly Ser Ser Gln Lys Ala His Gly Ile Leu Ala Arg Arg Pro Ser Tyr 
    50                  55                  60                  


Arg Lys Ile Leu Lys Asp Leu Ser Ser Glu Asp Xaa Arg Gly Arg Lys 
65                  70                  75                  80  


Gly Asp Gly Glu Asn Ser Gly Val Ser Ala Ala Val Xaa Ser Met Ser 
                85                  90                  95      


Val Pro Xaa Pro Ile Tyr Gln Xaa Ser Ser Gly Gln Tyr Ile Ala Ile 
            100                 105                 110         


Ala Pro Asn Gly Ala Leu Gln Leu Ala Ser Pro Gly Xaa Asp Gly Val 
        115                 120                 125             


Gln Gly Leu Gln Xaa Leu Xaa Met Xaa Asn Ser Gly Ser Xaa Gln Gln 
    130                 135                 140                 


Gly Xaa Xaa Ile Leu Gln Tyr Ala Gln Xaa Ser Asp Gly Gln Gln Ile 
145                 150                 155                 160 


Leu Val Pro Ser Asn Gln Val Val Val Gln Xaa Ala Ser Gly Asp Met 
                165                 170                 175     


Gln Xaa Tyr Gln Ile Arg Xaa Xaa Pro Ser Ala Xaa Ser Leu Pro Gln 
            180                 185                 190         


Xaa Val Val Met Xaa Ser Pro Val 
        195                 200 


<210> 3453
<211> 271
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<400> 3453
Met Glu Asp Ser His Lys Ser Xaa Xaa Ser Glu Xaa Ala Pro Gln Pro 
1               5                   10                  15      


Gly Ser Ala Val Gln Gly Ala His Ile Ser His Ile Ala Gln Gln Val 
            20                  25                  30          


Ser Ser Leu Ser Glu Ser Glu Glu Ser Gln Asp Ser Ser Asp Ser Ile 
        35                  40                  45              


Gly Ser Ser Gln Lys Ala His Gly Ile Leu Ala Arg Arg Pro Ser Tyr 
    50                  55                  60                  


Arg Lys Ile Leu Lys Asp Leu Ser Ser Glu Asp Xaa Arg Gly Arg Lys 
65                  70                  75                  80  


Gly Asp Gly Glu Asn Ser Gly Val Ser Ala Ala Val Xaa Ser Met Ser 
                85                  90                  95      


Val Pro Xaa Pro Ile Tyr Gln Xaa Ser Ser Gly Gln Tyr Ile Ala Ile 
            100                 105                 110         


Ala Pro Asn Gly Ala Leu Gln Leu Ala Ser Pro Gly Xaa Asp Gly Val 
        115                 120                 125             


Gln Gly Leu Gln Xaa Leu Xaa Met Xaa Asn Ser Gly Ser Xaa Gln Gln 
    130                 135                 140                 


Gly Xaa Xaa Ile Leu Gln Tyr Ala Gln Xaa Ser Asp Gly Gln Gln Ile 
145                 150                 155                 160 


Leu Val Pro Ser Asn Gln Val Val Val Gln Xaa Ala Ser Gly Asp Met 
                165                 170                 175     


Gln Xaa Tyr Gln Ile Arg Xaa Xaa Pro Ser Ala Xaa Ser Leu Pro Gln 
            180                 185                 190         


Xaa Val Val Met Xaa Ser Pro Val Xaa Leu Xaa Ser Gln Xaa Xaa Lys 
        195                 200                 205             


Xaa Asp Asp Pro Gln Leu Lys Arg Glu Ile Arg Leu Met Lys Asn Arg 
    210                 215                 220                 


Glu Ala Ala Arg Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys Cys 
225                 230                 235                 240 


Leu Glu Asn Arg Val Ala Val Leu Glu Asn Gln Asn Lys Xaa Leu Ile 
                245                 250                 255     


Glu Glu Leu Lys Xaa Leu Lys Asp Leu Tyr Ser Asn Lys Ser Val 
            260                 265                 270     


<210> 3454
<211> 329
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<400> 3454
Met Ala Ala Tyr Lys Phe Gln Ile Ile Gln Gln Ala Val Pro Ser Pro 
1               5                   10                  15      


Xaa Ser Ser Xaa Val Ile Xaa Gln Ala Pro Ser Ser Asn Arg Pro Ile 
            20                  25                  30          


Val Pro Val Pro Gly Pro Phe Pro Leu Leu Leu His Leu Pro Asn Gly 
        35                  40                  45              


Gln Xaa Met Pro Val Ala Ile Pro Ala Ser Ile Xaa Ser Ser Asn Val 
    50                  55                  60                  


His Val Pro Ala Ala Val Pro Leu Val Arg Pro Val Xaa Met Val Pro 
65                  70                  75                  80  


Ser Val Pro Gly Ile Pro Gly Pro Ser Ser Pro Gln Pro Val Gln Ser 
                85                  90                  95      


Glu Ala Lys Met Arg Leu Lys Ala Ala Leu Xaa Gln Gln His Pro Pro 
            100                 105                 110         


Val Xaa Asn Gly Asp Xaa Val Lys Gly His Gly Ser Gly Leu Val Arg 
        115                 120                 125             


Xaa Gln Ser Glu Glu Ser Arg Pro Gln Ser Leu Gln Gln Pro Ala Xaa 
    130                 135                 140                 


Ser Xaa Xaa Glu Xaa Pro Ala Ser Pro Ala His Xaa Xaa Pro Gln Xaa 
145                 150                 155                 160 


Gln Ser Xaa Ser Gly Arg Arg Arg Arg Ala Ala Asn Glu Asp Pro Asp 
                165                 170                 175     


Glu Lys Arg Arg Lys Phe Leu Glu Arg Asn Arg Ala Ala Ala Ser Arg 
            180                 185                 190         


Cys Arg Gln Lys Arg Lys Val Trp Val Gln Ser Leu Glu Lys Lys Ala 
        195                 200                 205             


Glu Asp Leu Ser Ser Leu Asn Gly Gln Leu Gln Ser Glu Val Xaa Leu 
    210                 215                 220                 


Leu Arg Asn Glu Val Ala Gln Leu Lys Gln Leu Leu Leu Ala His Lys 
225                 230                 235                 240 


Asp Cys Pro Val Xaa Ala Met Gln Lys Lys Ser Gly Tyr His Xaa Ala 
                245                 250                 255     


Asp Lys Asp Asp Ser Ser Glu Asp Ile Ser Val Pro Ser Ser Pro His 
            260                 265                 270         


Xaa Glu Ala Ile Gln His Ser Ser Val Ser Xaa Ser Asn Gly Val Ser 
        275                 280                 285             


Ser Xaa Ser Lys Ala Glu Ala Val Ala Xaa Ser Val Leu Xaa Gln Met 
    290                 295                 300                 


Ala Asp Gln Ser Xaa Glu Pro Ala Leu Ser Gln Ile Val Met Ala Pro 
305                 310                 315                 320 


Ser Ser Gln Ser Gln Pro Ser Gly Ser 
                325                 


<210> 3455
<211> 43
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<400> 3455
Met Lys Phe Lys Leu His Val Asn Ser Ala Arg Gln Tyr Lys Asp Leu 
1               5                   10                  15      


Trp Asn Met Ser Asp Asp Lys Pro Phe Leu Cys Xaa Ala Pro Gly Cys 
            20                  25                  30          


Gly Gln Ile Arg Pro Gln His Gln Gln Asp Ser 
        35                  40              


<210> 3456
<211> 209
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<400> 3456
Met Lys Phe Lys Leu His Val Asn Ser Ala Arg Gln Tyr Lys Asp Leu 
1               5                   10                  15      


Trp Asn Met Ser Asp Asp Lys Pro Phe Leu Cys Xaa Ala Pro Gly Cys 
            20                  25                  30          


Gly Gln Arg Phe Xaa Asn Glu Asp His Leu Ala Val His Lys His Lys 
        35                  40                  45              


His Glu Met Xaa Leu Lys Phe Gly Pro Ala Arg Asn Asp Ser Val Ile 
    50                  55                  60                  


Val Ala Asp Gln Xaa Pro Xaa Pro Xaa Arg Phe Leu Lys Asn Cys Glu 
65                  70                  75                  80  


Glu Val Gly Leu Phe Asn Glu Leu Ala Ser Pro Phe Glu Asn Glu Phe 
                85                  90                  95      


Lys Lys Ala Ser Glu Asp Asp Ile Lys Lys Met Pro Leu Asp Leu Ser 
            100                 105                 110         


Pro Leu Ala Xaa Pro Ile Ile Arg Ser Lys Ile Glu Glu Pro Ser Val 
        115                 120                 125             


Val Glu Xaa Xaa His Gln Asp Ser Pro Leu Pro His Pro Glu Ser Xaa 
    130                 135                 140                 


Xaa Ser Asp Glu Lys Glu Val Pro Leu Ala Gln Xaa Ala Gln Pro Xaa 
145                 150                 155                 160 


Ser Ala Ile Val Arg Pro Ala Ser Leu Gln Val Pro Asn Val Leu Leu 
                165                 170                 175     


Xaa Ser Ser Asp Ser Ser Val Ile Ile Gln Gln Ala Val Pro Ser Pro 
            180                 185                 190         


Xaa Ser Ser Xaa Val Ile Xaa Gln Ala Pro Ser Ser Asn Arg Pro Ile 
        195                 200                 205             


Val 
    


<210> 3457
<211> 395
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<400> 3457
Met Lys Phe Lys Leu His Val Asn Ser Ala Arg Gln Tyr Lys Asp Leu 
1               5                   10                  15      


Trp Asn Met Ser Asp Asp Lys Pro Phe Leu Cys Xaa Ala Pro Gly Cys 
            20                  25                  30          


Gly Gln Arg Phe Xaa Asn Glu Asp His Leu Ala Val His Lys His Lys 
        35                  40                  45              


His Glu Met Xaa Leu Lys Phe Gly Pro Ala Arg Asn Asp Ser Val Ile 
    50                  55                  60                  


Val Ala Asp Gln Xaa Pro Xaa Pro Xaa Arg Phe Leu Lys Asn Cys Glu 
65                  70                  75                  80  


Glu Val Gly Leu Phe Asn Glu Leu Ala Ser Pro Phe Glu Asn Glu Phe 
                85                  90                  95      


Lys Lys Ala Ser Glu Asp Asp Ile Lys Lys Met Pro Leu Asp Leu Ser 
            100                 105                 110         


Pro Leu Ala Xaa Pro Ile Ile Arg Ser Lys Ile Glu Glu Pro Ser Val 
        115                 120                 125             


Val Glu Xaa Xaa His Gln Asp Ser Pro Leu Pro His Pro Glu Ser Xaa 
    130                 135                 140                 


Xaa Ser Asp Glu Lys Glu Val Pro Leu Ala Gln Xaa Ala Gln Pro Xaa 
145                 150                 155                 160 


Ser Ala Ile Val Arg Pro Ala Ser Leu Gln Val Pro Asn Val Leu Leu 
                165                 170                 175     


Xaa Ser Ser Asp Ser Ser Val Ile Ile Gln Gln Ala Val Pro Ser Pro 
            180                 185                 190         


Xaa Ser Ser Xaa Val Ile Xaa Gln Ala Pro Ser Ser Asn Arg Pro Ile 
        195                 200                 205             


Val Pro Val Pro Gly Pro Phe Pro Leu Leu Leu His Leu Pro Asn Gly 
    210                 215                 220                 


Gln Xaa Met Pro Val Ala Ile Pro Ala Ser Ile Xaa Ser Ser Asn Val 
225                 230                 235                 240 


His Val Pro Ala Ala Val Pro Leu Val Arg Pro Val Xaa Met Val Pro 
                245                 250                 255     


Ser Val Pro Gly Ile Pro Gly Pro Ser Ser Pro Gln Pro Val Gln Ser 
            260                 265                 270         


Glu Ala Lys Met Arg Leu Lys Ala Ala Leu Xaa Gln Gln His Pro Pro 
        275                 280                 285             


Val Xaa Asn Gly Asp Xaa Val Lys Gly His Gly Ser Gly Leu Val Arg 
    290                 295                 300                 


Xaa Gln Ser Glu Glu Ser Arg Pro Gln Ser Leu Gln Gln Pro Ala Xaa 
305                 310                 315                 320 


Ser Xaa Xaa Glu Xaa Pro Ala Ser Pro Ala His Xaa Xaa Pro Gln Xaa 
                325                 330                 335     


Gln Ser Xaa Ser Gly Arg Arg Arg Arg Ala Ala Asn Glu Asp Pro Asp 
            340                 345                 350         


Glu Lys Arg Arg Lys Phe Leu Glu Arg Asn Arg Ala Ala Ala Ser Arg 
        355                 360                 365             


Cys Arg Gln Lys Arg Lys Val Trp Val Gln Ser Leu Glu Lys Lys Ala 
    370                 375                 380                 


Glu Asp Leu Ser Ser Leu Asn Gly Gln Leu Gln 
385                 390                 395 


<210> 3458
<211> 505
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<400> 3458
Met Lys Phe Lys Leu His Val Asn Ser Ala Arg Gln Tyr Lys Asp Leu 
1               5                   10                  15      


Trp Asn Met Ser Asp Asp Lys Pro Phe Leu Cys Xaa Ala Pro Gly Cys 
            20                  25                  30          


Gly Gln Arg Phe Xaa Asn Glu Asp His Leu Ala Val His Lys His Lys 
        35                  40                  45              


His Glu Met Xaa Leu Lys Phe Gly Pro Ala Arg Asn Asp Ser Val Ile 
    50                  55                  60                  


Val Ala Asp Gln Xaa Pro Xaa Pro Xaa Arg Phe Leu Lys Asn Cys Glu 
65                  70                  75                  80  


Glu Val Gly Leu Phe Asn Glu Leu Ala Ser Pro Phe Glu Asn Glu Phe 
                85                  90                  95      


Lys Lys Ala Ser Glu Asp Asp Ile Lys Lys Met Pro Leu Asp Leu Ser 
            100                 105                 110         


Pro Leu Ala Xaa Pro Ile Ile Arg Ser Lys Ile Glu Glu Pro Ser Val 
        115                 120                 125             


Val Glu Xaa Xaa His Gln Asp Ser Pro Leu Pro His Pro Glu Ser Xaa 
    130                 135                 140                 


Xaa Ser Asp Glu Lys Glu Val Pro Leu Ala Gln Xaa Ala Gln Pro Xaa 
145                 150                 155                 160 


Ser Ala Ile Val Arg Pro Ala Ser Leu Gln Val Pro Asn Val Leu Leu 
                165                 170                 175     


Xaa Ser Ser Asp Ser Ser Val Ile Ile Gln Gln Ala Val Pro Ser Pro 
            180                 185                 190         


Xaa Ser Ser Xaa Val Ile Xaa Gln Ala Pro Ser Ser Asn Arg Pro Ile 
        195                 200                 205             


Val Pro Val Pro Gly Pro Phe Pro Leu Leu Leu His Leu Pro Asn Gly 
    210                 215                 220                 


Gln Xaa Met Pro Val Ala Ile Pro Ala Ser Ile Xaa Ser Ser Asn Val 
225                 230                 235                 240 


His Val Pro Ala Ala Val Pro Leu Val Arg Pro Val Xaa Met Val Pro 
                245                 250                 255     


Ser Val Pro Gly Ile Pro Gly Pro Ser Ser Pro Gln Pro Val Gln Ser 
            260                 265                 270         


Glu Ala Lys Met Arg Leu Lys Ala Ala Leu Xaa Gln Gln His Pro Pro 
        275                 280                 285             


Val Xaa Asn Gly Asp Xaa Val Lys Gly His Gly Ser Gly Leu Val Arg 
    290                 295                 300                 


Xaa Gln Ser Glu Glu Ser Arg Pro Gln Ser Leu Gln Gln Pro Ala Xaa 
305                 310                 315                 320 


Ser Xaa Xaa Glu Xaa Pro Ala Ser Pro Ala His Xaa Xaa Pro Gln Xaa 
                325                 330                 335     


Gln Ser Xaa Ser Gly Arg Arg Arg Arg Ala Ala Asn Glu Asp Pro Asp 
            340                 345                 350         


Glu Lys Arg Arg Lys Phe Leu Glu Arg Asn Arg Ala Ala Ala Ser Arg 
        355                 360                 365             


Cys Arg Gln Lys Arg Lys Val Trp Val Gln Ser Leu Glu Lys Lys Ala 
    370                 375                 380                 


Glu Asp Leu Ser Ser Leu Asn Gly Gln Leu Gln Ser Glu Val Xaa Leu 
385                 390                 395                 400 


Leu Arg Asn Glu Val Ala Gln Leu Lys Gln Leu Leu Leu Ala His Lys 
                405                 410                 415     


Asp Cys Pro Val Xaa Ala Met Gln Lys Lys Ser Gly Tyr His Xaa Ala 
            420                 425                 430         


Asp Lys Asp Asp Ser Ser Glu Asp Ile Ser Val Pro Ser Ser Pro His 
        435                 440                 445             


Xaa Glu Ala Ile Gln His Ser Ser Val Ser Xaa Ser Asn Gly Val Ser 
    450                 455                 460                 


Ser Xaa Ser Lys Ala Glu Ala Val Ala Xaa Ser Val Leu Xaa Gln Met 
465                 470                 475                 480 


Ala Asp Gln Ser Xaa Glu Pro Ala Leu Ser Gln Ile Val Met Ala Pro 
                485                 490                 495     


Ser Ser Gln Ser Gln Pro Ser Gly Ser 
            500                 505 


<210> 3459
<211> 237
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<400> 3459
Met Lys Phe Lys Leu His Val Asn Ser Ala Arg Gln Tyr Lys Asp Leu 
1               5                   10                  15      


Trp Asn Met Ser Asp Asp Lys Pro Phe Leu Cys Xaa Ala Pro Gly Cys 
            20                  25                  30          


Gly Gln Arg Phe Xaa Asn Glu Asp His Leu Ala Val His Lys His Lys 
        35                  40                  45              


His Glu Met Xaa Leu Lys Phe Gly Pro Ala Arg Asn Asp Ser Val Ile 
    50                  55                  60                  


Val Ala Asp Gln Xaa Pro Xaa Pro Xaa Arg Phe Leu Lys Asn Cys Glu 
65                  70                  75                  80  


Glu Val Gly Leu Phe Asn Glu Leu Ala Ser Pro Phe Glu Asn Glu Phe 
                85                  90                  95      


Lys Lys Ala Ser Glu Asp Asp Ile Lys Lys Met Pro Leu Asp Leu Ser 
            100                 105                 110         


Pro Leu Ala Xaa Pro Ile Ile Arg Ser Lys Ile Glu Glu Pro Ser Val 
        115                 120                 125             


Val Glu Xaa Xaa His Gln Asp Ser Pro Leu Pro His Pro Glu Ser Xaa 
    130                 135                 140                 


Xaa Ser Asp Glu Lys Glu Val Pro Leu Ala Gln Xaa Ala Gln Pro Xaa 
145                 150                 155                 160 


Ser Ala Ile Val Arg Pro Ala Ser Leu Gln Val Pro Asn Val Leu Leu 
                165                 170                 175     


Xaa Ser Ser Asp Ser Ser Val Ile Ile Gln Gln Ala Val Pro Ser Pro 
            180                 185                 190         


Xaa Ser Ser Xaa Val Ile Xaa Gln Ala Pro Ser Ser Asn Arg Pro Ile 
        195                 200                 205             


Val Ser Phe Asp Gln Ser Pro Trp Cys Leu Val Phe Gln Glu Ser Gln 
    210                 215                 220                 


Val Leu Pro Leu Pro Asn Gln Tyr Ser Gln Lys Gln Lys 
225                 230                 235         


<210> 3460
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<400> 3460
Met Lys Phe Lys Leu His Val Asn Ser Ala Arg Gln Tyr Lys Asp Leu 
1               5                   10                  15      


Trp Asn Met Ser Asp Asp Lys Pro Phe Leu Cys Xaa Ala Pro Gly Cys 
            20                  25                  30          


Gly Gln Ser Glu Val Xaa Leu Leu Arg Asn Glu Val Ala Gln Leu Lys 
        35                  40                  45              


Gln Leu Leu Leu Ala His Lys Asp Cys Pro Val Xaa Ala Met Gln Lys 
    50                  55                  60                  


Lys Ser Gly Tyr His Xaa Ala Asp Lys Asp Asp Ser Ser Glu Asp Ile 
65                  70                  75                  80  


Ser Val Pro Ser Ser Pro His Xaa Glu Ala Ile Gln His Ser Ser Val 
                85                  90                  95      


Ser Xaa Ser Asn Gly Val Ser Ser Xaa Ser Lys Ala Glu Ala Val Ala 
            100                 105                 110         


Xaa Ser Val Leu Xaa Gln Met Ala Asp Gln Ser Xaa Glu Pro Ala Leu 
        115                 120                 125             


Ser Gln Ile Val Met Ala Pro Ser Ser Gln Ser Gln Pro Ser Gly Ser 
    130                 135                 140                 


<210> 3461
<211> 487
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<400> 3461
Met Ser Asp Asp Lys Pro Phe Leu Cys Xaa Ala Pro Gly Cys Gly Gln 
1               5                   10                  15      


Arg Phe Xaa Asn Glu Asp His Leu Ala Val His Lys His Lys His Glu 
            20                  25                  30          


Met Xaa Leu Lys Phe Gly Pro Ala Arg Asn Asp Ser Val Ile Val Ala 
        35                  40                  45              


Asp Gln Xaa Pro Xaa Pro Xaa Arg Phe Leu Lys Asn Cys Glu Glu Val 
    50                  55                  60                  


Gly Leu Phe Asn Glu Leu Ala Ser Pro Phe Glu Asn Glu Phe Lys Lys 
65                  70                  75                  80  


Ala Ser Glu Asp Asp Ile Lys Lys Met Pro Leu Asp Leu Ser Pro Leu 
                85                  90                  95      


Ala Xaa Pro Ile Ile Arg Ser Lys Ile Glu Glu Pro Ser Val Val Glu 
            100                 105                 110         


Xaa Xaa His Gln Asp Ser Pro Leu Pro His Pro Glu Ser Xaa Xaa Ser 
        115                 120                 125             


Asp Glu Lys Glu Val Pro Leu Ala Gln Xaa Ala Gln Pro Xaa Ser Ala 
    130                 135                 140                 


Ile Val Arg Pro Ala Ser Leu Gln Val Pro Asn Val Leu Leu Xaa Ser 
145                 150                 155                 160 


Ser Asp Ser Ser Val Ile Ile Gln Gln Ala Val Pro Ser Pro Xaa Ser 
                165                 170                 175     


Ser Xaa Val Ile Xaa Gln Ala Pro Ser Ser Asn Arg Pro Ile Val Pro 
            180                 185                 190         


Val Pro Gly Pro Phe Pro Leu Leu Leu His Leu Pro Asn Gly Gln Xaa 
        195                 200                 205             


Met Pro Val Ala Ile Pro Ala Ser Ile Xaa Ser Ser Asn Val His Val 
    210                 215                 220                 


Pro Ala Ala Val Pro Leu Val Arg Pro Val Xaa Met Val Pro Ser Val 
225                 230                 235                 240 


Pro Gly Ile Pro Gly Pro Ser Ser Pro Gln Pro Val Gln Ser Glu Ala 
                245                 250                 255     


Lys Met Arg Leu Lys Ala Ala Leu Xaa Gln Gln His Pro Pro Val Xaa 
            260                 265                 270         


Asn Gly Asp Xaa Val Lys Gly His Gly Ser Gly Leu Val Arg Xaa Gln 
        275                 280                 285             


Ser Glu Glu Ser Arg Pro Gln Ser Leu Gln Gln Pro Ala Xaa Ser Xaa 
    290                 295                 300                 


Xaa Glu Xaa Pro Ala Ser Pro Ala His Xaa Xaa Pro Gln Xaa Gln Ser 
305                 310                 315                 320 


Xaa Ser Gly Arg Arg Arg Arg Ala Ala Asn Glu Asp Pro Asp Glu Lys 
                325                 330                 335     


Arg Arg Lys Phe Leu Glu Arg Asn Arg Ala Ala Ala Ser Arg Cys Arg 
            340                 345                 350         


Gln Lys Arg Lys Val Trp Val Gln Ser Leu Glu Lys Lys Ala Glu Asp 
        355                 360                 365             


Leu Ser Ser Leu Asn Gly Gln Leu Gln Ser Glu Val Xaa Leu Leu Arg 
    370                 375                 380                 


Asn Glu Val Ala Gln Leu Lys Gln Leu Leu Leu Ala His Lys Asp Cys 
385                 390                 395                 400 


Pro Val Xaa Ala Met Gln Lys Lys Ser Gly Tyr His Xaa Ala Asp Lys 
                405                 410                 415     


Asp Asp Ser Ser Glu Asp Ile Ser Val Pro Ser Ser Pro His Xaa Glu 
            420                 425                 430         


Ala Ile Gln His Ser Ser Val Ser Xaa Ser Asn Gly Val Ser Ser Xaa 
        435                 440                 445             


Ser Lys Ala Glu Ala Val Ala Xaa Ser Val Leu Xaa Gln Met Ala Asp 
    450                 455                 460                 


Gln Ser Xaa Glu Pro Ala Leu Ser Gln Ile Val Met Ala Pro Ser Ser 
465                 470                 475                 480 


Gln Ser Gln Pro Ser Gly Ser 
                485         


<210> 3462
<211> 389
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<400> 3462
Met Ser Asp Asp Lys Pro Phe Leu Cys Xaa Ala Pro Gly Cys Gly Gln 
1               5                   10                  15      


Arg Phe Xaa Asn Glu Asp His Leu Ala Val His Lys His Lys His Glu 
            20                  25                  30          


Met Xaa Leu Lys Phe Gly Pro Ala Arg Asn Asp Ser Val Ile Val Ala 
        35                  40                  45              


Asp Gln Xaa Pro Xaa Pro Xaa Arg Phe Leu Lys Asn Cys Glu Glu Val 
    50                  55                  60                  


Gly Leu Phe Asn Glu Leu Ala Ser Pro Phe Glu Asn Glu Phe Lys Lys 
65                  70                  75                  80  


Ala Ser Glu Asp Asp Ile Lys Lys Met Pro Leu Asp Leu Ser Pro Leu 
                85                  90                  95      


Ala Xaa Pro Ile Ile Arg Ser Lys Ile Glu Glu Pro Ser Val Val Glu 
            100                 105                 110         


Xaa Xaa His Gln Asp Ser Pro Leu Pro His Pro Glu Ser Xaa Xaa Ser 
        115                 120                 125             


Asp Glu Lys Leu Val Arg Pro Val Xaa Met Val Pro Ser Val Pro Gly 
    130                 135                 140                 


Ile Pro Gly Pro Ser Ser Pro Gln Pro Val Gln Ser Glu Ala Lys Met 
145                 150                 155                 160 


Arg Leu Lys Ala Ala Leu Xaa Gln Gln His Pro Pro Val Xaa Asn Gly 
                165                 170                 175     


Asp Xaa Val Lys Gly His Gly Ser Gly Leu Val Arg Xaa Gln Ser Glu 
            180                 185                 190         


Glu Ser Arg Pro Gln Ser Leu Gln Gln Pro Ala Xaa Ser Xaa Xaa Glu 
        195                 200                 205             


Xaa Pro Ala Ser Pro Ala His Xaa Xaa Pro Gln Xaa Gln Ser Xaa Ser 
    210                 215                 220                 


Gly Arg Arg Arg Arg Ala Ala Asn Glu Asp Pro Asp Glu Lys Arg Arg 
225                 230                 235                 240 


Lys Phe Leu Glu Arg Asn Arg Ala Ala Ala Ser Arg Cys Arg Gln Lys 
                245                 250                 255     


Arg Lys Val Trp Val Gln Ser Leu Glu Lys Lys Ala Glu Asp Leu Ser 
            260                 265                 270         


Ser Leu Asn Gly Gln Leu Gln Ser Glu Val Xaa Leu Leu Arg Asn Glu 
        275                 280                 285             


Val Ala Gln Leu Lys Gln Leu Leu Leu Ala His Lys Asp Cys Pro Val 
    290                 295                 300                 


Xaa Ala Met Gln Lys Lys Ser Gly Tyr His Xaa Ala Asp Lys Asp Asp 
305                 310                 315                 320 


Ser Ser Glu Asp Ile Ser Val Pro Ser Ser Pro His Xaa Glu Ala Ile 
                325                 330                 335     


Gln His Ser Ser Val Ser Xaa Ser Asn Gly Val Ser Ser Xaa Ser Lys 
            340                 345                 350         


Ala Glu Ala Val Ala Xaa Ser Val Leu Xaa Gln Met Ala Asp Gln Ser 
        355                 360                 365             


Xaa Glu Pro Ala Leu Ser Gln Ile Val Met Ala Pro Ser Ser Gln Ser 
    370                 375                 380                 


Gln Pro Ser Gly Ser 
385                 


<210> 3463
<211> 189
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<400> 3463
Met Tyr Cys Ala Trp Met Trp Pro Asp Gln Xaa Pro Xaa Pro Xaa Arg 
1               5                   10                  15      


Phe Leu Lys Asn Cys Glu Glu Val Gly Leu Phe Asn Glu Leu Ala Ser 
            20                  25                  30          


Pro Phe Glu Asn Glu Phe Lys Lys Ala Ser Glu Asp Asp Ile Lys Lys 
        35                  40                  45              


Met Pro Leu Asp Leu Ser Pro Leu Ala Xaa Pro Ile Ile Arg Ser Lys 
    50                  55                  60                  


Ile Glu Glu Pro Ser Val Val Glu Xaa Xaa His Gln Asp Ser Pro Leu 
65                  70                  75                  80  


Pro His Pro Glu Ser Xaa Xaa Ser Asp Glu Lys Glu Val Pro Leu Ala 
                85                  90                  95      


Gln Xaa Ala Gln Pro Xaa Ser Ala Ile Val Arg Pro Ala Ser Leu Gln 
            100                 105                 110         


Val Pro Asn Val Leu Leu Xaa Ser Ser Asp Ser Ser Val Ile Ile Gln 
        115                 120                 125             


Gln Ala Val Pro Ser Pro Xaa Ser Ser Xaa Val Ile Xaa Gln Ala Pro 
    130                 135                 140                 


Ser Ser Asn Arg Pro Ile Val Pro Val Pro Gly Pro Phe Pro Leu Leu 
145                 150                 155                 160 


Leu His Leu Pro Asn Gly Gln Xaa Met Pro Val Ala Ile Pro Ala Ser 
                165                 170                 175     


Ile Xaa Ser Ser Asn Val His Val Pro Ala Ala Val Pro 
            180                 185                 


<210> 3464
<211> 447
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<400> 3464
Met Tyr Cys Ala Trp Met Trp Pro Asp Gln Xaa Pro Xaa Pro Xaa Arg 
1               5                   10                  15      


Phe Leu Lys Asn Cys Glu Glu Val Gly Leu Phe Asn Glu Leu Ala Ser 
            20                  25                  30          


Pro Phe Glu Asn Glu Phe Lys Lys Ala Ser Glu Asp Asp Ile Lys Lys 
        35                  40                  45              


Met Pro Leu Asp Leu Ser Pro Leu Ala Xaa Pro Ile Ile Arg Ser Lys 
    50                  55                  60                  


Ile Glu Glu Pro Ser Val Val Glu Xaa Xaa His Gln Asp Ser Pro Leu 
65                  70                  75                  80  


Pro His Pro Glu Ser Xaa Xaa Ser Asp Glu Lys Glu Val Pro Leu Ala 
                85                  90                  95      


Gln Xaa Ala Gln Pro Xaa Ser Ala Ile Val Arg Pro Ala Ser Leu Gln 
            100                 105                 110         


Val Pro Asn Val Leu Leu Xaa Ser Ser Asp Ser Ser Val Ile Ile Gln 
        115                 120                 125             


Gln Ala Val Pro Ser Pro Xaa Ser Ser Xaa Val Ile Xaa Gln Ala Pro 
    130                 135                 140                 


Ser Ser Asn Arg Pro Ile Val Pro Val Pro Gly Pro Phe Pro Leu Leu 
145                 150                 155                 160 


Leu His Leu Pro Asn Gly Gln Xaa Met Pro Val Ala Ile Pro Ala Ser 
                165                 170                 175     


Ile Xaa Ser Ser Asn Val His Val Pro Ala Ala Val Pro Leu Val Arg 
            180                 185                 190         


Pro Val Xaa Met Val Pro Ser Val Pro Gly Ile Pro Gly Pro Ser Ser 
        195                 200                 205             


Pro Gln Pro Val Gln Ser Glu Ala Lys Met Arg Leu Lys Ala Ala Leu 
    210                 215                 220                 


Xaa Gln Gln His Pro Pro Val Xaa Asn Gly Asp Xaa Val Lys Gly His 
225                 230                 235                 240 


Gly Ser Gly Leu Val Arg Xaa Gln Ser Glu Glu Ser Arg Pro Gln Ser 
                245                 250                 255     


Leu Gln Gln Pro Ala Xaa Ser Xaa Xaa Glu Xaa Pro Ala Ser Pro Ala 
            260                 265                 270         


His Xaa Xaa Pro Gln Xaa Gln Ser Xaa Ser Gly Arg Arg Arg Arg Ala 
        275                 280                 285             


Ala Asn Glu Asp Pro Asp Glu Lys Arg Arg Lys Phe Leu Glu Arg Asn 
    290                 295                 300                 


Arg Ala Ala Ala Ser Arg Cys Arg Gln Lys Arg Lys Val Trp Val Gln 
305                 310                 315                 320 


Ser Leu Glu Lys Lys Ala Glu Asp Leu Ser Ser Leu Asn Gly Gln Leu 
                325                 330                 335     


Gln Ser Glu Val Xaa Leu Leu Arg Asn Glu Val Ala Gln Leu Lys Gln 
            340                 345                 350         


Leu Leu Leu Ala His Lys Asp Cys Pro Val Xaa Ala Met Gln Lys Lys 
        355                 360                 365             


Ser Gly Tyr His Xaa Ala Asp Lys Asp Asp Ser Ser Glu Asp Ile Ser 
    370                 375                 380                 


Val Pro Ser Ser Pro His Xaa Glu Ala Ile Gln His Ser Ser Val Ser 
385                 390                 395                 400 


Xaa Ser Asn Gly Val Ser Ser Xaa Ser Lys Ala Glu Ala Val Ala Xaa 
                405                 410                 415     


Ser Val Leu Xaa Gln Met Ala Asp Gln Ser Xaa Glu Pro Ala Leu Ser 
            420                 425                 430         


Gln Ile Val Met Ala Pro Ser Ser Gln Ser Gln Pro Ser Gly Ser 
        435                 440                 445         


<210> 3465
<211> 265
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<400> 3465
Xaa Tyr Lys Asp Leu Trp Asn Met Ser Asp Asp Lys Pro Phe Leu Cys 
1               5                   10                  15      


Xaa Ala Pro Gly Cys Gly Gln Arg Phe Xaa Asn Glu Asp His Leu Ala 
            20                  25                  30          


Val His Lys His Lys His Glu Met Xaa Leu Lys Phe Gly Pro Ala Arg 
        35                  40                  45              


Asn Asp Ser Val Ile Val Ala Asp Gln Xaa Pro Xaa Pro Xaa Arg Phe 
    50                  55                  60                  


Leu Lys Asn Cys Glu Glu Val Gly Leu Phe Asn Glu Leu Ala Ser Pro 
65                  70                  75                  80  


Phe Glu Asn Glu Phe Lys Lys Ala Ser Glu Asp Asp Ile Lys Lys Met 
                85                  90                  95      


Pro Leu Asp Leu Ser Pro Leu Ala Xaa Pro Ile Ile Arg Ser Lys Ile 
            100                 105                 110         


Glu Glu Pro Ser Val Val Glu Xaa Xaa His Gln Asp Ser Pro Leu Pro 
        115                 120                 125             


His Pro Glu Ser Xaa Xaa Ser Asp Glu Lys Glu Val Pro Leu Ala Gln 
    130                 135                 140                 


Xaa Ala Gln Pro Xaa Ser Ala Ile Val Arg Pro Ala Ser Pro Ala His 
145                 150                 155                 160 


Xaa Xaa Pro Gln Xaa Gln Ser Xaa Ser Gly Arg Arg Arg Arg Ala Ala 
                165                 170                 175     


Asn Glu Asp Pro Asp Glu Lys Arg Arg Lys Phe Leu Glu Arg Asn Arg 
            180                 185                 190         


Ala Ala Ala Ser Arg Cys Arg Gln Lys Arg Lys Val Trp Val Gln Ser 
        195                 200                 205             


Leu Glu Lys Lys Ala Glu Asp Leu Ser Ser Leu Asn Gly Gln Leu Gln 
    210                 215                 220                 


Leu Leu Ile Lys Met Ile Val Gln Lys Xaa Phe Gln Cys Arg Val Val 
225                 230                 235                 240 


His Ile Gln Lys Leu Tyr Ser Ile Val Arg Ser Ala His Pro Met Glu 
                245                 250                 255     


Ser Val Gln Pro Pro Arg Gln Lys Leu 
            260                 265 


<210> 3466
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<400> 3466
Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Glu Glu Leu 
1               5                   10                  15      


Arg Phe Ala Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala 
            20                  25                  30          


Leu Glu Ser Val Xaa Val Ser Asp Arg Pro Leu Gly Val Ser Ile Xaa 
        35                  40                  45              


Lys Ala Glu Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg 
    50                  55                  60                  


Glu Arg Asn Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu 
65                  70                  75                  80  


Lys Xaa Glu Cys Leu Gln Lys Leu Pro Arg Pro Phe Trp Val Gln Lys 
                85                  90                  95      


Xaa Cys Ile Trp Ala Val Asp Ser Cys Lys 
            100                 105     


<210> 3467
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 3467
Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Val Ser Ala 
1               5                   10                  15      


Ser Ala Ile Val Pro Cys Leu Ser Pro Pro Gly Ser Leu Val Phe Glu 
            20                  25                  30          


Asp Phe Ala Asn Leu Xaa Pro Phe Val Lys Glu Glu Leu Arg Phe Ala 
        35                  40                  45              


Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala Leu Glu Ser 
    50                  55                  60                  


Val Xaa Val Ser Asp Arg Pro Leu Gly Val Ser Ile Xaa Lys Ala Glu 
65                  70                  75                  80  


Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg Glu Arg Asn 
                85                  90                  95      


Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu Lys Xaa Glu 
            100                 105                 110         


Cys Leu Gln Lys Glu Ser Glu Lys Leu Glu Ser Val Asn Ala Glu Leu 
        115                 120                 125             


Lys Ala Gln Ile Glu Glu Leu Lys Asn Glu Lys Gln His Leu Ile Tyr 
    130                 135                 140                 


Met Leu Asn Leu His Arg Pro Xaa Cys Ile Val Arg Ala Gln Asn Gly 
145                 150                 155                 160 


Arg Xaa Pro Glu Asp Glu Arg Asn Leu Phe Ile Gln Gln Ile Lys 
                165                 170                 175 


<210> 3468
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<400> 3468
Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Val Ser Ala 
1               5                   10                  15      


Ser Ala Ile Val Pro Cys Leu Ser Pro Pro Gly Ser Leu Val Phe Glu 
            20                  25                  30          


Asp Phe Ala Asn Leu Xaa Pro Phe Val Lys Glu Glu Leu Arg Phe Ala 
        35                  40                  45              


Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala Leu Glu Ser 
    50                  55                  60                  


Val Xaa Val Ser Asp Arg Pro Leu Gly Val Ser Ile Xaa Lys Ala Glu 
65                  70                  75                  80  


Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg Glu Arg Asn 
                85                  90                  95      


Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu Lys Xaa Glu 
            100                 105                 110         


Cys Leu Gln Lys Glu Ser Glu Lys Leu Glu Ser Val Asn Ala Glu Leu 
        115                 120                 125             


Lys Ala Gln Ile Glu Glu Leu Lys Asn Glu Lys Gln His Leu Ile Tyr 
    130                 135                 140                 


Met Leu Asn Leu His Arg Pro Xaa Cys Ile Val Arg Ala Gln Asn Gly 
145                 150                 155                 160 


Arg Xaa Pro Glu Asp Glu Arg Asn Leu Phe Ile Gln Gln Ile Lys Glu 
                165                 170                 175     


Gly Xaa Leu Gln Ser 
            180     


<210> 3469
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<400> 3469
Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Val Ser Ala 
1               5                   10                  15      


Ser Ala Ile Val Pro Cys Leu Ser Pro Pro Gly Ser Leu Val Phe Glu 
            20                  25                  30          


Asp Phe Ala Asn Leu Xaa Pro Phe Val Lys Glu Glu Leu Arg Phe Ala 
        35                  40                  45              


Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala Leu Glu Ser 
    50                  55                  60                  


Val Xaa Val Ser Asp Arg Pro Leu Gly Val Ser Ile Xaa Lys Ala Glu 
65                  70                  75                  80  


Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg Glu Arg Asn 
                85                  90                  95      


Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu Lys Xaa Glu 
            100                 105                 110         


Cys Leu Gln Lys Leu Pro Arg Pro Phe Trp Val Gln Lys Xaa Cys Ile 
        115                 120                 125             


Trp Ala Val Asp Ser Cys Lys 
    130                 135 


<210> 3470
<211> 124
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<400> 3470
Met Ser Ser Ala Leu Glu Ser Val Xaa Val Ser Asp Arg Pro Leu Gly 
1               5                   10                  15      


Val Ser Ile Xaa Lys Ala Glu Val Ala Pro Glu Glu Asp Glu Arg Lys 
            20                  25                  30          


Lys Arg Arg Arg Glu Arg Asn Lys Ile Ala Ala Ala Lys Cys Arg Asn 
        35                  40                  45              


Lys Lys Lys Glu Lys Xaa Glu Cys Leu Gln Lys Glu Ser Glu Lys Leu 
    50                  55                  60                  


Glu Ser Val Asn Ala Glu Leu Lys Ala Gln Ile Glu Glu Leu Lys Asn 
65                  70                  75                  80  


Glu Lys Gln His Leu Ile Tyr Met Leu Asn Leu His Arg Pro Xaa Cys 
                85                  90                  95      


Ile Val Arg Ala Gln Asn Gly Arg Xaa Pro Glu Asp Glu Arg Asn Leu 
            100                 105                 110         


Phe Ile Gln Gln Ile Lys Glu Gly Xaa Leu Gln Ser 
        115                 120                 


<210> 3471
<211> 153
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 3471
Xaa Glu Arg Ser Leu Glu Gln Asn Asp Ala Ser Xaa Pro Arg Pro Glu 
1               5                   10                  15      


Leu Arg Phe Ala Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser 
            20                  25                  30          


Ala Leu Glu Ser Val Xaa Val Ser Asp Arg Pro Leu Gly Val Ser Ile 
        35                  40                  45              


Xaa Lys Ala Glu Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg 
    50                  55                  60                  


Arg Glu Arg Asn Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys 
65                  70                  75                  80  


Glu Lys Xaa Glu Cys Leu Gln Lys Glu Ser Glu Lys Leu Glu Ser Val 
                85                  90                  95      


Asn Ala Glu Leu Lys Ala Gln Ile Glu Glu Leu Lys Asn Glu Lys Gln 
            100                 105                 110         


His Leu Ile Tyr Met Leu Asn Leu His Arg Pro Xaa Cys Ile Val Arg 
        115                 120                 125             


Ala Gln Asn Gly Arg Xaa Pro Glu Asp Glu Arg Asn Leu Phe Ile Gln 
    130                 135                 140                 


Gln Ile Lys Glu Gly Xaa Leu Gln Ser 
145                 150             


<210> 3472
<211> 351
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<400> 3472
Met Xaa Glu Met Ser Phe Leu Ser Ser Glu Val Leu Val Gly Asp Leu 
1               5                   10                  15      


Met Ser Pro Phe Asp Gln Ser Gly Leu Gly Ala Glu Glu Ser Leu Gly 
            20                  25                  30          


Leu Leu Asp Asp Tyr Leu Glu Val Ala Lys His Phe Lys Pro His Gly 
        35                  40                  45              


Phe Ser Ser Asp Lys Ala Lys Ala Gly Ser Ser Glu Trp Leu Ala Val 
    50                  55                  60                  


Asp Gly Leu Val Ser Pro Ser Asn Asn Ser Lys Glu Asp Ala Phe Ser 
65                  70                  75                  80  


Gly Xaa Asp Trp Met Leu Glu Lys Met Asp Leu Lys Glu Phe Asp Leu 
                85                  90                  95      


Asp Ala Leu Leu Gly Ile Asp Asp Leu Glu Xaa Met Pro Asp Asp Leu 
            100                 105                 110         


Leu Xaa Xaa Leu Asp Asp Xaa Cys Asp Leu Phe Ala Pro Leu Val Gln 
        115                 120                 125             


Glu Xaa Asn Lys Gln Pro Pro Gln Xaa Val Asn Pro Ile Gly His Leu 
    130                 135                 140                 


Pro Glu Ser Leu Xaa Lys Pro Asp Gln Val Ala Pro Phe Xaa Phe Leu 
145                 150                 155                 160 


Gln Pro Leu Pro Leu Ser Pro Gly Val Leu Ser Ser Xaa Pro Asp His 
                165                 170                 175     


Ser Phe Ser Leu Glu Leu Gly Ser Glu Val Asp Ile Xaa Glu Gly Asp 
            180                 185                 190         


Arg Lys Pro Asp Tyr Xaa Ala Tyr Val Ala Met Ile Pro Gln Cys Ile 
        195                 200                 205             


Lys Glu Glu Asp Xaa Pro Ser Asp Asn Asp Ser Gly Ile Cys Met Ser 
    210                 215                 220                 


Pro Glu Ser Tyr Leu Gly Ser Pro Gln His Ser Pro Ser Xaa Arg Gly 
225                 230                 235                 240 


Ser Pro Asn Arg Ser Leu Pro Ser Pro Gly Val Leu Cys Gly Ser Ala 
                245                 250                 255     


Arg Pro Lys Pro Tyr Asp Pro Pro Gly Glu Lys Met Val Ala Ala Lys 
            260                 265                 270         


Val Lys Gly Glu Lys Leu Asp Lys Lys Leu Lys Lys Met Glu Gln Asn 
        275                 280                 285             


Lys Xaa Ala Ala Xaa Arg Tyr Arg Gln Lys Lys Arg Ala Glu Gln Glu 
    290                 295                 300                 


Ala Leu Xaa Gly Glu Cys Lys Glu Leu Glu Lys Lys Asn Glu Ala Leu 
305                 310                 315                 320 


Lys Glu Arg Ala Asp Ser Leu Ala Lys Glu Ile Gln Tyr Leu Lys Asp 
                325                 330                 335     


Leu Ile Glu Glu Val Arg Lys Ala Arg Gly Lys Lys Arg Val Pro 
            340                 345                 350     


<210> 3473
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<400> 3473
Met Ser Leu Leu Ala Xaa Leu Gly Leu Glu Leu Asp Arg Ala Leu Leu 
1               5                   10                  15      


Pro Ala Ser Gly Leu Gly Trp Leu Val Asp Tyr Gly Lys Leu Pro Pro 
            20                  25                  30          


Ala Pro Ala Pro Leu Ala Pro Tyr Glu Val Leu Gly Gly Ala Leu Glu 
        35                  40                  45              


Gly Gly Leu Pro Val Gly Gly Glu Pro Leu Ala Gly Asp Gly Phe Ser 
    50                  55                  60                  


Asp Trp Met Xaa Glu Arg Val Asp Phe Xaa Ala Leu Leu Pro Leu Glu 
65                  70                  75                  80  


Pro Pro Leu Pro Pro Gly Xaa Leu Pro Gln Pro Ser Pro Xaa Pro Pro 
                85                  90                  95      


Asp Leu Glu Ala Met Ala Ser Leu Leu Lys Lys Glu Leu Glu Gln Met 
            100                 105                 110         


Glu Asp Phe Phe Leu Asp Ala Pro Pro Leu 
        115                 120         


<210> 3474
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<400> 3474
Met Ser Leu Leu Ala Xaa Leu Gly Leu Glu Leu Asp Arg Ala Leu Leu 
1               5                   10                  15      


Pro Ala Ser Gly Leu Gly Trp Leu Val Asp Tyr Gly Lys Leu Pro Pro 
            20                  25                  30          


Ala Pro Ala Pro Leu Ala Pro Tyr Glu Val Leu Gly Gly Ala Leu Glu 
        35                  40                  45              


Gly Gly Leu Pro Val Gly Gly Glu Pro Leu Ala Gly Asp Gly Phe Ser 
    50                  55                  60                  


Asp Trp Met Xaa Glu Arg Val Asp Phe Xaa Ala Leu Leu Pro Leu Glu 
65                  70                  75                  80  


Pro Pro Leu Pro Pro Gly Xaa Leu Pro Gln Pro Ser Pro Xaa Pro Pro 
                85                  90                  95      


Asp Leu Glu Ala Met Ala Ser Leu Leu Lys Lys Glu Leu Glu Gln Met 
            100                 105                 110         


Glu Asp Phe Phe Leu Asp Ala Pro Pro Leu Pro Pro Pro Ser Pro Pro 
        115                 120                 125             


Pro Leu 
    130 


<210> 3475
<211> 282
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<400> 3475
Met Ser Leu Leu Ala Xaa Leu Gly Leu Glu Leu Asp Arg Ala Leu Leu 
1               5                   10                  15      


Pro Ala Ser Gly Leu Gly Trp Leu Val Asp Tyr Gly Lys Leu Pro Pro 
            20                  25                  30          


Ala Pro Ala Pro Leu Ala Pro Tyr Glu Val Leu Gly Gly Ala Leu Glu 
        35                  40                  45              


Gly Gly Leu Pro Val Gly Gly Glu Pro Leu Ala Gly Asp Gly Phe Ser 
    50                  55                  60                  


Asp Trp Met Xaa Glu Arg Val Asp Phe Xaa Ala Leu Leu Pro Leu Glu 
65                  70                  75                  80  


Pro Pro Leu Pro Pro Gly Xaa Leu Pro Gln Pro Ser Pro Xaa Pro Pro 
                85                  90                  95      


Asp Leu Glu Ala Met Ala Ser Leu Leu Lys Lys Glu Leu Glu Gln Met 
            100                 105                 110         


Glu Asp Phe Phe Leu Asp Ala Pro Pro Leu Pro Pro Pro Ser Pro Pro 
        115                 120                 125             


Pro Leu Pro Pro Pro Pro Leu Pro Pro Ala Pro Ser Leu Pro Leu Ser 
    130                 135                 140                 


Leu Pro Ser Phe Asp Leu Pro Gln Pro Pro Val Leu Asp Xaa Leu Asp 
145                 150                 155                 160 


Leu Leu Ala Ile Tyr Cys Arg Asn Glu Ala Gly Gln Glu Glu Val Gly 
                165                 170                 175     


Met Pro Pro Leu Pro Pro Pro Gln Gln Pro Pro Pro Pro Ser Pro Pro 
            180                 185                 190         


Gln Pro Ser Arg Leu Ala Pro Tyr Pro His Pro Ala Xaa Xaa Arg Gly 
        195                 200                 205             


Asp Arg Lys Gln Lys Lys Arg Asp Gln Asn Lys Ser Ala Ala Leu Arg 
    210                 215                 220                 


Tyr Arg Gln Arg Lys Arg Ala Glu Gly Glu Ala Leu Glu Gly Glu Cys 
225                 230                 235                 240 


Gln Gly Leu Glu Ala Arg Asn Arg Glu Leu Lys Glu Arg Ala Glu Ser 
                245                 250                 255     


Val Glu Arg Glu Ile Gln Tyr Val Lys Asp Leu Leu Ile Glu Val Tyr 
            260                 265                 270         


Lys Ala Arg Ser Gln Arg Xaa Arg Ser Cys 
        275                 280         


<210> 3476
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<400> 3476
Met Ser Leu Leu Ala Xaa Leu Gly Leu Glu Leu Asp Arg Ala Leu Leu 
1               5                   10                  15      


Pro Ala Ser Gly Leu Gly Trp Leu Val Asp Tyr Gly Lys Leu Pro Pro 
            20                  25                  30          


Ala Pro Ala Pro Leu Ala Pro Tyr Glu Val Leu Gly Gly Ala Leu Glu 
        35                  40                  45              


Gly Gly Leu Pro Val Gly Gly Glu Pro Leu Ala Gly Lys Gly Arg Trp 
    50                  55                  60                  


Lys Val Glu Leu Gly Ser Gly Gly Gln Gly Lys Met Gly Glu Glu Glu 
65                  70                  75                  80  


Leu Ile His Val Phe Asn Lys Tyr 
                85              


<210> 3477
<211> 670
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<400> 3477
Met Gly Glu Pro Ala Gly Val Ala Gly Xaa Met Glu Ser Pro Phe Ser 
1               5                   10                  15      


Pro Gly Leu Phe His Arg Leu Asp Glu Asp Trp Asp Ser Ala Leu Phe 
            20                  25                  30          


Ala Glu Leu Gly Tyr Phe Xaa Asp Xaa Asp Glu Leu Gln Leu Glu Ala 
        35                  40                  45              


Ala Asn Glu Xaa Tyr Glu Asn Asn Phe Asp Asn Leu Asp Phe Asp Leu 
    50                  55                  60                  


Asp Leu Met Pro Trp Glu Ser Asp Ile Trp Asp Ile Asn Asn Gln Ile 
65                  70                  75                  80  


Cys Xaa Val Lys Asp Ile Lys Ala Glu Pro Gln Pro Leu Ser Pro Ala 
                85                  90                  95      


Ser Ser Ser Tyr Ser Val Ser Ser Pro Arg Ser Val Asp Ser Tyr Ser 
            100                 105                 110         


Ser Xaa Gln His Val Pro Glu Glu Leu Asp Leu Ser Ser Ser Ser Gln 
        115                 120                 125             


Met Ser Pro Leu Ser Leu Tyr Gly Glu Asn Ser Asn Ser Leu Ser Ser 
    130                 135                 140                 


Ala Glu Pro Leu Lys Glu Asp Lys Pro Val Xaa Gly Pro Arg Asn Lys 
145                 150                 155                 160 


Xaa Glu Asn Gly Leu Xaa Pro Lys Lys Lys Ile Gln Val Asn Ser Lys 
                165                 170                 175     


Pro Ser Ile Gln Pro Lys Pro Leu Leu Leu Pro Ala Ala Pro Lys Xaa 
            180                 185                 190         


Gln Xaa Asn Ser Ser Val Pro Ala Lys Xaa Ile Ile Ile Gln Xaa Val 
        195                 200                 205             


Pro Xaa Leu Met Pro Leu Ala Lys Gln Gln Pro Ile Ile Ser Leu Gln 
    210                 215                 220                 


Pro Ala Pro Xaa Lys Gly Gln Xaa Val Leu Leu Ser Gln Pro Xaa Val 
225                 230                 235                 240 


Val Gln Leu Gln Ala Pro Gly Val Leu Pro Ser Ala Gln Pro Val Leu 
                245                 250                 255     


Ala Val Ala Gly Gly Val Xaa Gln Leu Pro Asn His Val Val Asn Val 
            260                 265                 270         


Val Pro Ala Pro Ser Ala Asn Ser Pro Val Asn Gly Lys Leu Ser Val 
        275                 280                 285             


Xaa Lys Pro Val Leu Gln Ser Xaa Met Arg Asn Val Gly Ser Asp Ile 
    290                 295                 300                 


Ala Val Leu Arg Arg Gln Gln Arg Met Ile Lys Asn Arg Glu Ser Ala 
305                 310                 315                 320 


Cys Gln Ser Arg Lys Lys Lys Lys Glu Tyr Met Leu Gly Leu Glu Ala 
                325                 330                 335     


Arg Leu Lys Ala Ala Leu Ser Glu Asn Glu Gln Leu Lys Lys Glu Asn 
            340                 345                 350         


Gly Xaa Leu Lys Arg Gln Leu Asp Glu Val Val Ser Glu Asn Gln Arg 
        355                 360                 365             


Leu Lys Val Pro Ser Pro Lys Arg Arg Val Val Cys Val Met Ile Val 
    370                 375                 380                 


Leu Ala Phe Ile Ile Leu Asn Tyr Gly Pro Met Ser Met Leu Glu Gln 
385                 390                 395                 400 


Asp Ser Arg Arg Met Asn Pro Ser Val Ser Pro Ala Asn Gln Arg Arg 
                405                 410                 415     


His Leu Leu Gly Phe Ser Ala Lys Glu Ala Gln Asp Xaa Ser Asp Gly 
            420                 425                 430         


Ile Ile Gln Lys Asn Ser Tyr Arg Tyr Asp His Ser Val Ser Asn Asp 
        435                 440                 445             


Lys Ala Leu Met Val Leu Xaa Glu Glu Pro Leu Leu Tyr Ile Pro Pro 
    450                 455                 460                 


Pro Pro Cys Gln Pro Leu Ile Asn Xaa Xaa Glu Ser Leu Arg Leu Asn 
465                 470                 475                 480 


His Glu Leu Arg Gly Trp Val His Arg His Glu Val Glu Arg Xaa Lys 
                485                 490                 495     


Ser Arg Arg Met Xaa Asn Asn Gln Gln Lys Xaa Arg Ile Leu Gln Gly 
            500                 505                 510         


Ala Leu Glu Gln Gly Ser Asn Ser Gln Leu Met Ala Val Gln Tyr Xaa 
        515                 520                 525             


Glu Xaa Xaa Ser Ser Ile Ser Arg Asn Ser Gly Ser Glu Leu Gln Val 
    530                 535                 540                 


Tyr Tyr Ala Ser Pro Arg Ser Tyr Gln Asp Phe Phe Glu Ala Ile Arg 
545                 550                 555                 560 


Arg Arg Gly Asp Xaa Phe Tyr Val Val Ser Phe Arg Arg Asp His Leu 
                565                 570                 575     


Leu Leu Pro Ala Xaa Xaa His Asn Lys Xaa Xaa Arg Pro Lys Met Ser 
            580                 585                 590         


Ile Val Leu Pro Ala Ile Asn Ile Asn Glu Asn Val Ile Asn Gly Gln 
        595                 600                 605             


Asp Tyr Glu Val Met Met Gln Ile Asp Cys Gln Val Met Asp Xaa Arg 
    610                 615                 620                 


Ile Leu His Ile Lys Ser Ser Ser Val Pro Pro Tyr Leu Arg Asp Gln 
625                 630                 635                 640 


Gln Arg Asn Gln Xaa Asn Xaa Phe Phe Gly Ser Pro Pro Ala Ala Xaa 
                645                 650                 655     


Glu Ala Xaa His Val Val Ser Xaa Ile Pro Glu Ser Leu Gln 
            660                 665                 670 


<210> 3478
<211> 700
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<400> 3478
Met Ala Glu Leu Met Leu Leu Ser Glu Ile Ala Asp Pro Xaa Arg Phe 
1               5                   10                  15      


Phe Xaa Asp Asn Leu Leu Ser Pro Glu Asp Trp Asp Ser Xaa Leu Tyr 
            20                  25                  30          


Ser Gly Leu Asp Glu Val Ala Glu Glu Gln Xaa Gln Leu Phe Arg Cys 
        35                  40                  45              


Pro Glu Gln Asp Val Pro Phe Asp Gly Ser Ser Leu Asp Val Gly Met 
    50                  55                  60                  


Asp Val Ser Pro Ser Glu Pro Pro Trp Glu Leu Leu Pro Ile Phe Pro 
65                  70                  75                  80  


Asp Leu Gln Val Lys Ser Glu Pro Ser Ser Pro Cys Ser Ser Ser Ser 
                85                  90                  95      


Leu Ser Ser Glu Ser Ser Arg Leu Ser Xaa Glu Pro Ser Ser Glu Ala 
            100                 105                 110         


Leu Gly Val Gly Glu Val Leu His Val Lys Xaa Glu Ser Leu Ala Pro 
        115                 120                 125             


Pro Leu Cys Leu Leu Gly Asp Asp Pro Xaa Ser Ser Phe Glu Xaa Val 
    130                 135                 140                 


Gln Ile Asn Val Ile Pro Xaa Ser Asp Asp Ser Ser Asp Val Gln Xaa 
145                 150                 155                 160 


Lys Ile Glu Pro Val Ser Pro Cys Ser Ser Val Asn Ser Glu Ala Ser 
                165                 170                 175     


Leu Leu Ser Ala Asp Ser Ser Ser Gln Ala Phe Ile Gly Glu Glu Val 
            180                 185                 190         


Leu Glu Val Lys Xaa Glu Ser Leu Ser Pro Ser Gly Cys Leu Leu Trp 
        195                 200                 205             


Asp Val Pro Ala Pro Ser Leu Gly Ala Val Gln Ile Ser Met Gly Pro 
    210                 215                 220                 


Ser Leu Asp Gly Ser Ser Gly Lys Ala Leu Pro Xaa Arg Lys Pro Pro 
225                 230                 235                 240 


Leu Gln Pro Lys Pro Val Val Leu Xaa Xaa Val Pro Met Pro Ser Arg 
                245                 250                 255     


Ala Val Pro Pro Ser Xaa Xaa Val Leu Leu Gln Ser Leu Val Gln Pro 
            260                 265                 270         


Pro Pro Val Ser Pro Val Val Leu Ile Gln Gly Ala Ile Arg Val Gln 
        275                 280                 285             


Pro Glu Gly Pro Ala Pro Ser Leu Pro Arg Pro Glu Arg Lys Ser Ile 
    290                 295                 300                 


Val Pro Ala Pro Met Pro Gly Asn Ser Cys Pro Pro Glu Val Asp Ala 
305                 310                 315                 320 


Lys Leu Leu Lys Arg Gln Gln Arg Met Ile Lys Asn Arg Glu Ser Ala 
                325                 330                 335     


Cys Gln Ser Arg Arg Lys Lys Lys Glu Tyr Leu Gln Gly Leu Glu Ala 
            340                 345                 350         


Arg Leu Gln Ala Val Leu Ala Asp Asn Gln Gln Leu Arg Arg Glu Asn 
        355                 360                 365             


Ala Ala Leu Arg Arg Arg Leu Glu Ala Leu Leu Ala Glu Asn Ser Glu 
    370                 375                 380                 


Leu Lys Leu Gly Ser Gly Asn Arg Lys Val Val Cys Ile Met Val Phe 
385                 390                 395                 400 


Leu Leu Phe Ile Ala Phe Asn Phe Gly Pro Val Ser Ile Ser Glu Pro 
                405                 410                 415     


Pro Ser Ala Pro Ile Ser Pro Arg Met Asn Lys Gly Glu Pro Gln Pro 
            420                 425                 430         


Arg Arg His Leu Leu Gly Phe Ser Glu Gln Glu Pro Val Gln Gly Val 
        435                 440                 445             


Glu Pro Leu Gln Gly Ser Ser Gln Gly Pro Lys Glu Pro Gln Pro Ser 
    450                 455                 460                 


Pro Xaa Asp Gln Pro Ser Phe Ser Asn Leu Xaa Ala Phe Pro Gly Gly 
465                 470                 475                 480 


Ala Lys Glu Leu Leu Leu Arg Asp Leu Asp Gln Leu Phe Leu Ser Ser 
                485                 490                 495     


Asp Cys Arg His Phe Asn Arg Xaa Glu Ser Leu Arg Leu Ala Asp Glu 
            500                 505                 510         


Leu Ser Gly Trp Val Gln Arg His Gln Arg Gly Arg Arg Lys Ile Pro 
        515                 520                 525             


Gln Arg Ala Gln Glu Arg Gln Lys Ser Gln Pro Arg Lys Lys Ser Pro 
    530                 535                 540                 


Pro Val Lys Ala Val Pro Ile Gln Pro Pro Gly Pro Pro Glu Arg Asp 
545                 550                 555                 560 


Ser Val Gly Gln Leu Gln Leu Tyr Arg His Pro Asp Arg Ser Gln Pro 
                565                 570                 575     


Ala Phe Leu Asp Ala Ile Asp Arg Arg Glu Asp Xaa Phe Tyr Val Val 
            580                 585                 590         


Ser Phe Arg Arg Asp His Leu Leu Leu Pro Ala Ile Ser His Asn Lys 
        595                 600                 605             


Xaa Ser Arg Pro Lys Met Ser Leu Val Met Pro Ala Met Ala Pro Asn 
    610                 615                 620                 


Glu Xaa Leu Ser Gly Arg Gly Ala Pro Gly Asp Tyr Glu Glu Met Met 
625                 630                 635                 640 


Gln Ile Glu Cys Glu Val Met Asp Xaa Arg Val Ile His Ile Lys Xaa 
                645                 650                 655     


Ser Xaa Val Pro Pro Ser Leu Arg Lys Gln Pro Ser Pro Xaa Pro Gly 
            660                 665                 670         


Asn Ala Xaa Gly Gly Pro Leu Pro Val Ser Ala Ala Ser Gln Ala His 
        675                 680                 685             


Gln Ala Ser His Gln Pro Leu Tyr Leu Asn His Pro 
    690                 695                 700 


<210> 3479
<211> 703
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<400> 3479
Met Ala Glu Leu Met Leu Leu Ser Glu Ile Ala Asp Pro Xaa Arg Phe 
1               5                   10                  15      


Phe Xaa Asp Asn Leu Leu Ser Pro Glu Asp Trp Gly Leu Gln Asn Ser 
            20                  25                  30          


Xaa Leu Tyr Ser Gly Leu Asp Glu Val Ala Glu Glu Gln Xaa Gln Leu 
        35                  40                  45              


Phe Arg Cys Pro Glu Gln Asp Val Pro Phe Asp Gly Ser Ser Leu Asp 
    50                  55                  60                  


Val Gly Met Asp Val Ser Pro Ser Glu Pro Pro Trp Glu Leu Leu Pro 
65                  70                  75                  80  


Ile Phe Pro Asp Leu Gln Val Lys Ser Glu Pro Ser Ser Pro Cys Ser 
                85                  90                  95      


Ser Ser Ser Leu Ser Ser Glu Ser Ser Arg Leu Ser Xaa Glu Pro Ser 
            100                 105                 110         


Ser Glu Ala Leu Gly Val Gly Glu Val Leu His Val Lys Xaa Glu Ser 
        115                 120                 125             


Leu Ala Pro Pro Leu Cys Leu Leu Gly Asp Asp Pro Xaa Ser Ser Phe 
    130                 135                 140                 


Glu Xaa Val Gln Ile Asn Val Ile Pro Xaa Ser Asp Asp Ser Ser Asp 
145                 150                 155                 160 


Val Gln Xaa Lys Ile Glu Pro Val Ser Pro Cys Ser Ser Val Asn Ser 
                165                 170                 175     


Glu Ala Ser Leu Leu Ser Ala Asp Ser Ser Ser Gln Ala Phe Ile Gly 
            180                 185                 190         


Glu Glu Val Leu Glu Val Lys Xaa Glu Ser Leu Ser Pro Ser Gly Cys 
        195                 200                 205             


Leu Leu Trp Asp Val Pro Ala Pro Ser Leu Gly Ala Val Gln Ile Ser 
    210                 215                 220                 


Met Gly Pro Ser Leu Asp Gly Ser Ser Gly Lys Ala Leu Pro Xaa Arg 
225                 230                 235                 240 


Lys Pro Pro Leu Gln Pro Lys Pro Val Val Leu Xaa Xaa Val Pro Met 
                245                 250                 255     


Pro Ser Arg Ala Val Pro Pro Ser Xaa Xaa Val Leu Leu Gln Ser Leu 
            260                 265                 270         


Val Gln Pro Pro Pro Val Ser Pro Val Val Leu Ile Gln Gly Ala Ile 
        275                 280                 285             


Arg Val Gln Pro Glu Gly Pro Ala Pro Ser Leu Pro Arg Pro Glu Arg 
    290                 295                 300                 


Lys Ser Ile Val Pro Ala Pro Met Pro Gly Asn Ser Cys Pro Pro Glu 
305                 310                 315                 320 


Val Asp Ala Lys Leu Leu Lys Arg Gln Gln Arg Met Ile Lys Asn Arg 
                325                 330                 335     


Glu Ser Ala Cys Gln Ser Arg Arg Lys Lys Lys Glu Tyr Leu Gln Gly 
            340                 345                 350         


Leu Glu Ala Arg Leu Gln Ala Val Leu Ala Asp Asn Gln Gln Leu Arg 
        355                 360                 365             


Arg Glu Asn Ala Ala Leu Arg Arg Arg Leu Glu Ala Leu Leu Ala Glu 
    370                 375                 380                 


Asn Ser Glu Leu Lys Leu Gly Ser Gly Asn Arg Lys Val Val Cys Ile 
385                 390                 395                 400 


Met Val Phe Leu Leu Phe Ile Ala Phe Asn Phe Gly Pro Val Ser Ile 
                405                 410                 415     


Ser Glu Pro Pro Ser Ala Pro Ile Ser Pro Arg Met Asn Lys Gly Glu 
            420                 425                 430         


Pro Gln Pro Arg Arg His Leu Leu Gly Phe Ser Glu Gln Glu Pro Val 
        435                 440                 445             


Gln Gly Val Glu Pro Leu Gln Gly Ser Ser Gln Gly Pro Lys Glu Pro 
    450                 455                 460                 


Gln Pro Ser Pro Xaa Asp Gln Pro Ser Phe Ser Asn Leu Xaa Ala Phe 
465                 470                 475                 480 


Pro Gly Gly Ala Lys Glu Leu Leu Leu Arg Asp Leu Asp Gln Leu Phe 
                485                 490                 495     


Leu Ser Ser Asp Cys Arg His Phe Asn Arg Xaa Glu Ser Leu Arg Leu 
            500                 505                 510         


Ala Asp Glu Leu Ser Gly Trp Val Gln Arg His Gln Arg Gly Arg Arg 
        515                 520                 525             


Lys Ile Pro Gln Arg Ala Gln Glu Arg Gln Lys Ser Gln Pro Arg Lys 
    530                 535                 540                 


Lys Ser Pro Pro Val Lys Ala Val Pro Ile Gln Pro Pro Gly Pro Pro 
545                 550                 555                 560 


Glu Arg Asp Ser Val Gly Gln Leu Gln Leu Tyr Arg His Pro Asp Arg 
                565                 570                 575     


Ser Gln Pro Ala Phe Leu Asp Ala Ile Asp Arg Arg Glu Asp Xaa Phe 
            580                 585                 590         


Tyr Val Val Ser Phe Arg Arg Asp His Leu Leu Leu Pro Ala Ile Ser 
        595                 600                 605             


His Asn Lys Xaa Ser Arg Pro Lys Met Ser Leu Val Met Pro Ala Met 
    610                 615                 620                 


Ala Pro Asn Glu Xaa Leu Ser Gly Arg Gly Ala Pro Gly Asp Tyr Glu 
625                 630                 635                 640 


Glu Met Met Gln Ile Glu Cys Glu Val Met Asp Xaa Arg Val Ile His 
                645                 650                 655     


Ile Lys Xaa Ser Xaa Val Pro Pro Ser Leu Arg Lys Gln Pro Ser Pro 
            660                 665                 670         


Xaa Pro Gly Asn Ala Xaa Gly Gly Pro Leu Pro Val Ser Ala Ala Ser 
        675                 680                 685             


Gln Ala His Gln Ala Ser His Gln Pro Leu Tyr Leu Asn His Pro 
    690                 695                 700             


<210> 3480
<211> 142
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<400> 3480
Xaa Gln Pro Ser Pro Xaa Asp Gln Pro Ser Phe Ser Asn Leu Xaa Ala 
1               5                   10                  15      


Phe Pro Gly Gly Ala Lys Glu Leu Leu Leu Arg Asp Leu Asp Gln Leu 
            20                  25                  30          


Phe Leu Ser Ser Asp Cys Arg His Phe Asn Arg Xaa Glu Ser Leu Arg 
        35                  40                  45              


Leu Ala Asp Glu Leu Ser Gly Trp Val Gln Arg His Gln Arg Gly Arg 
    50                  55                  60                  


Arg Lys Ile Pro Gln Arg Ala Gln Glu Arg Gln Ser Leu Asp Xaa Ser 
65                  70                  75                  80  


Pro Ser Arg Ser Leu Ser His Gly Arg Ser His Leu Gln Leu Arg Gln 
                85                  90                  95      


Ser Pro Ser Asn Pro Leu Asp Pro Gln Lys Gly Ile Leu Trp Ala Ser 
            100                 105                 110         


Cys Asn Tyr Ile Ala Xaa Gln Xaa Val Arg Ser Gln His Ser Trp Met 
        115                 120                 125             


Gln Leu Xaa Asp Gly Lys Xaa His Phe Met Leu Ser Leu Ser 
    130                 135                 140         


<210> 3481
<211> 483
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<400> 3481
Met Gly Asp Asp Arg Pro Phe Val Cys Asn Ala Pro Gly Cys Gly Gln 
1               5                   10                  15      


Arg Phe Xaa Asn Glu Asp His Leu Ala Val His Lys His Lys His Glu 
            20                  25                  30          


Met Xaa Leu Lys Phe Gly Pro Ala Arg Xaa Asp Ser Val Ile Ile Ala 
        35                  40                  45              


Asp Gln Xaa Pro Xaa Pro Xaa Arg Phe Leu Lys Asn Cys Glu Glu Val 
    50                  55                  60                  


Gly Leu Phe Asn Glu Leu Ala Ser Ser Phe Glu His Glu Phe Lys Lys 
65                  70                  75                  80  


Ala Ala Asp Glu Asp Glu Lys Lys Ala Ala Ala Gly Pro Leu Asp Met 
                85                  90                  95      


Ser Leu Pro Ser Xaa Pro Asp Ile Lys Ile Lys Glu Glu Glu Pro Val 
            100                 105                 110         


Glu Val Asp Ser Ser Pro Pro Asp Ser Pro Ala Ser Ser Pro Cys Ser 
        115                 120                 125             


Pro Pro Leu Lys Glu Lys Glu Val Xaa Pro Lys Pro Val Leu Ile Ser 
    130                 135                 140                 


Xaa Pro Xaa Pro Xaa Ile Val Arg Pro Gly Ser Leu Pro Leu His Leu 
145                 150                 155                 160 


Gly Tyr Asp Pro Leu His Pro Xaa Leu Pro Ser Pro Xaa Ser Val Ile 
                165                 170                 175     


Xaa Gln Ala Pro Pro Ser Asn Arg Gln Met Gly Ser Pro Xaa Gly Ser 
            180                 185                 190         


Leu Pro Leu Val Met His Leu Ala Asn Gly Gln Xaa Met Pro Val Leu 
        195                 200                 205             


Pro Gly Pro Pro Val Gln Met Pro Ser Val Ile Ser Leu Ala Arg Pro 
    210                 215                 220                 


Val Ser Met Val Pro Asn Ile Pro Gly Ile Pro Gly Pro Pro Val Asn 
225                 230                 235                 240 


Ser Ser Gly Ser Ile Ser Pro Ser Gly His Pro Ile Pro Ser Glu Ala 
                245                 250                 255     


Lys Met Arg Leu Lys Ala Xaa Leu Xaa His Gln Val Ser Ser Ile Asn 
            260                 265                 270         


Gly Gly Cys Gly Met Val Val Gly Xaa Ala Ser Xaa Met Val Xaa Ala 
        275                 280                 285             


Arg Pro Glu Gln Ser Gln Ile Leu Ile Gln His Pro Asp Ala Pro Ser 
    290                 295                 300                 


Pro Ala Gln Pro Gln Val Ser Pro Ala Gln Pro Xaa Pro Ser Xaa Gly 
305                 310                 315                 320 


Gly Arg Arg Arg Arg Xaa Val Asp Glu Asp Pro Asp Glu Arg Arg Gln 
                325                 330                 335     


Arg Phe Leu Glu Arg Asn Arg Ala Ala Ala Ser Arg Cys Arg Gln Lys 
            340                 345                 350         


Arg Lys Leu Trp Val Ser Ser Leu Glu Lys Lys Ala Glu Glu Leu Xaa 
        355                 360                 365             


Ser Gln Asn Ile Gln Leu Ser Asn Glu Val Xaa Leu Leu Arg Asn Glu 
    370                 375                 380                 


Val Ala Gln Leu Lys Gln Leu Leu Leu Ala His Lys Asp Cys Pro Val 
385                 390                 395                 400 


Xaa Ala Leu Gln Lys Lys Xaa Gln Gly Tyr Leu Glu Ser Pro Lys Glu 
                405                 410                 415     


Ser Ser Glu Pro Xaa Gly Ser Pro Ala Pro Val Ile Gln His Ser Ser 
            420                 425                 430         


Ala Xaa Ala Pro Ser Asn Gly Leu Ser Val Arg Ser Ala Ala Glu Ala 
        435                 440                 445             


Val Ala Xaa Ser Val Leu Xaa Gln Met Ala Ser Gln Arg Xaa Glu Leu 
    450                 455                 460                 


Ser Met Pro Ile Gln Ser His Val Ile Met Xaa Pro Gln Ser Gln Ser 
465                 470                 475                 480 


Ala Gly Arg 
            


<210> 3482
<211> 163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<400> 3482
Met Gly Asp Asp Arg Pro Phe Val Cys Asn Ala Pro Gly Cys Gly Gln 
1               5                   10                  15      


Arg Phe Xaa Asn Glu Asp His Leu Ala Val His Lys His Lys His Glu 
            20                  25                  30          


Met Xaa Leu Lys Phe Gly Pro Ala Arg Xaa Asp Ser Val Ile Ile Ala 
        35                  40                  45              


Asp Gln Xaa Pro Xaa Pro Xaa Arg Phe Leu Lys Asn Cys Glu Glu Val 
    50                  55                  60                  


Gly Leu Phe Asn Glu Leu Ala Ser Ser Phe Glu His Glu Phe Lys Lys 
65                  70                  75                  80  


Ala Ala Asp Glu Asp Glu Lys Lys Ala Arg Ser Arg Xaa Val Ala Lys 
                85                  90                  95      


Lys Leu Val Ala Ala Ala Gly Pro Leu Asp Met Ser Leu Pro Ser Xaa 
            100                 105                 110         


Pro Asp Ile Lys Ile Lys Glu Glu Glu Pro Val Glu Val Asp Ser Ser 
        115                 120                 125             


Pro Pro Asp Ser Pro Ala Ser Ser Pro Cys Ser Pro Pro Leu Lys Glu 
    130                 135                 140                 


Lys Glu Val Xaa Pro Lys Pro Val Leu Ile Ser Xaa Pro Xaa Pro Xaa 
145                 150                 155                 160 


Ile Val Arg 
            


<210> 3483
<211> 494
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<400> 3483
Met Gly Asp Asp Arg Pro Phe Val Cys Asn Ala Pro Gly Cys Gly Gln 
1               5                   10                  15      


Arg Phe Xaa Asn Glu Asp His Leu Ala Val His Lys His Lys His Glu 
            20                  25                  30          


Met Xaa Leu Lys Phe Gly Pro Ala Arg Xaa Asp Ser Val Ile Ile Ala 
        35                  40                  45              


Asp Gln Xaa Pro Xaa Pro Xaa Arg Phe Leu Lys Asn Cys Glu Glu Val 
    50                  55                  60                  


Gly Leu Phe Asn Glu Leu Ala Ser Ser Phe Glu His Glu Phe Lys Lys 
65                  70                  75                  80  


Ala Ala Asp Glu Asp Glu Lys Lys Ala Arg Ser Arg Xaa Val Ala Lys 
                85                  90                  95      


Lys Leu Val Ala Ala Ala Gly Pro Leu Asp Met Ser Leu Pro Ser Xaa 
            100                 105                 110         


Pro Asp Ile Lys Ile Lys Glu Glu Glu Pro Val Glu Val Asp Ser Ser 
        115                 120                 125             


Pro Pro Asp Ser Pro Ala Ser Ser Pro Cys Ser Pro Pro Leu Lys Glu 
    130                 135                 140                 


Lys Glu Val Xaa Pro Lys Pro Val Leu Ile Ser Xaa Pro Xaa Pro Xaa 
145                 150                 155                 160 


Ile Val Arg Pro Gly Ser Leu Pro Leu His Leu Gly Tyr Asp Pro Leu 
                165                 170                 175     


His Pro Xaa Leu Pro Ser Pro Xaa Ser Val Ile Xaa Gln Ala Pro Pro 
            180                 185                 190         


Ser Asn Arg Gln Met Gly Ser Pro Xaa Gly Ser Leu Pro Leu Val Met 
        195                 200                 205             


His Leu Ala Asn Gly Gln Xaa Met Pro Val Leu Pro Gly Pro Pro Val 
    210                 215                 220                 


Gln Met Pro Ser Val Ile Ser Leu Ala Arg Pro Val Ser Met Val Pro 
225                 230                 235                 240 


Asn Ile Pro Gly Ile Pro Gly Pro Pro Val Asn Ser Ser Gly Ser Ile 
                245                 250                 255     


Ser Pro Ser Gly His Pro Ile Pro Ser Glu Ala Lys Met Arg Leu Lys 
            260                 265                 270         


Ala Xaa Leu Xaa His Gln Val Ser Ser Ile Asn Gly Gly Cys Gly Met 
        275                 280                 285             


Val Val Gly Xaa Ala Ser Xaa Met Val Xaa Ala Arg Pro Glu Gln Ser 
    290                 295                 300                 


Gln Ile Leu Ile Gln His Pro Asp Ala Pro Ser Pro Ala Gln Pro Gln 
305                 310                 315                 320 


Val Ser Pro Ala Gln Pro Xaa Pro Ser Xaa Gly Gly Arg Arg Arg Arg 
                325                 330                 335     


Xaa Val Asp Glu Asp Pro Asp Glu Arg Arg Gln Arg Phe Leu Glu Arg 
            340                 345                 350         


Asn Arg Ala Ala Ala Ser Arg Cys Arg Gln Lys Arg Lys Leu Trp Val 
        355                 360                 365             


Ser Ser Leu Glu Lys Lys Ala Glu Glu Leu Xaa Ser Gln Asn Ile Gln 
    370                 375                 380                 


Leu Ser Asn Glu Val Xaa Leu Leu Arg Asn Glu Val Ala Gln Leu Lys 
385                 390                 395                 400 


Gln Leu Leu Leu Ala His Lys Asp Cys Pro Val Xaa Ala Leu Gln Lys 
                405                 410                 415     


Lys Xaa Gln Gly Tyr Leu Glu Ser Pro Lys Glu Ser Ser Glu Pro Xaa 
            420                 425                 430         


Gly Ser Pro Ala Pro Val Ile Gln His Ser Ser Ala Xaa Ala Pro Ser 
        435                 440                 445             


Asn Gly Leu Ser Val Arg Ser Ala Ala Glu Ala Val Ala Xaa Ser Val 
    450                 455                 460                 


Leu Xaa Gln Met Ala Ser Gln Arg Xaa Glu Leu Ser Met Pro Ile Gln 
465                 470                 475                 480 


Ser His Val Ile Met Xaa Pro Gln Ser Gln Ser Ala Gly Arg 
                485                 490                 


<210> 3484
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<400> 3484
Met Gly Asp Asp Arg Pro Phe Val Cys Asn Ala Pro Gly Cys Gly Gln 
1               5                   10                  15      


Arg Phe Xaa Asn Glu Asp His Leu Ala Val His Lys His Lys His Glu 
            20                  25                  30          


Met Xaa Leu Lys Phe Gly Pro Ala Arg Xaa Asp Ser Val Ile Ile Ala 
        35                  40                  45              


Asp Gln Xaa Pro Xaa Pro Xaa Arg Phe Leu Lys Asn Cys Glu Glu Val 
    50                  55                  60                  


Gly Leu Phe Asn Glu Leu Ala Ser Ser Phe Glu His Glu Phe Lys Lys 
65                  70                  75                  80  


Ala Ala Asp Glu Asp Glu Lys Lys Ala Arg Ser Arg Xaa Val Ala Lys 
                85                  90                  95      


Lys Leu Val Val Phe Arg Pro Arg Leu Phe Leu Leu Cys Phe Gly Ile 
            100                 105                 110         


Ile Phe Leu Ile Gly 
        115         


<210> 3485
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 3485
Met Ser Leu Pro Ser Xaa Pro Asp Ile Lys Ile Lys Glu Glu Glu Pro 
1               5                   10                  15      


Val Glu Val Asp Ser Ser Pro Pro Asp Ser Pro Ala Ser Ser Pro Cys 
            20                  25                  30          


Ser Pro Pro Leu Lys Glu Lys Glu Val Xaa Pro Lys Pro Val Leu Ile 
        35                  40                  45              


Ser Xaa Pro Xaa Pro Xaa Ile Val Arg Pro Gly Ser Leu Pro Leu His 
    50                  55                  60                  


Leu Gly Tyr Asp Pro Leu His Pro Xaa Leu Pro Ser Pro Xaa 
65                  70                  75              


<210> 3486
<211> 79
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 3486
Met Ser Leu Pro Ser Xaa Pro Asp Ile Lys Ile Lys Glu Glu Glu Pro 
1               5                   10                  15      


Val Glu Val Asp Ser Ser Pro Pro Asp Ser Pro Ala Ser Ser Pro Cys 
            20                  25                  30          


Ser Pro Pro Leu Lys Glu Lys Glu Val Xaa Pro Lys Pro Val Leu Ile 
        35                  40                  45              


Ser Xaa Pro Xaa Pro Xaa Ile Val Arg Pro Gly Ser Leu Pro Leu His 
    50                  55                  60                  


Leu Gly Tyr Asp Pro Leu His Pro Xaa Leu Pro Ser Pro Xaa Ser 
65                  70                  75                  


<210> 3487
<211> 140
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<400> 3487
Met Ala Glu Glu Pro Gln Ser Val Leu Gln Leu Pro Xaa Ser Ile Ala 
1               5                   10                  15      


Ala Gly Gly Glu Gly Leu Xaa Asp Val Ser Pro Glu Xaa Xaa Xaa Pro 
            20                  25                  30          


Glu Pro Pro Ser Ser Ala Ala Val Ser Pro Gly Xaa Glu Glu Pro Ala 
        35                  40                  45              


Gly Asp Xaa Lys Lys Lys Ile Asp Ile Leu Leu Lys Ala Val Gly Asp 
    50                  55                  60                  


Xaa Pro Ile Met Lys Xaa Lys Lys Trp Ala Val Glu Arg Xaa Arg Xaa 
65                  70                  75                  80  


Ile Gln Gly Leu Ile Asp Phe Ile Lys Lys Phe Leu Lys Leu Val Ala 
                85                  90                  95      


Ser Glu Gln Leu Phe Ile Tyr Val Asn Gln Ser Phe Ala Pro Ser Pro 
            100                 105                 110         


Asp Gln Glu Val Gly Xaa Leu Tyr Glu Cys Phe Gly Ser Asp Gly Lys 
        115                 120                 125             


Leu Val Leu His Tyr Cys Lys Ser Gln Ala Trp Gly 
    130                 135                 140 


<210> 3488
<211> 74
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<400> 3488
Met Ala Glu Glu Pro Gln Ser Val Leu Gln Leu Pro Xaa Ser Ile Ala 
1               5                   10                  15      


Ala Gly Gly Glu Gly Leu Xaa Asp Val Ser Pro Glu Xaa Xaa Xaa Pro 
            20                  25                  30          


Glu Pro Pro Ser Ser Ala Ala Val Ser Pro Gly Xaa Glu Glu Pro Ala 
        35                  40                  45              


Gly Asp Xaa Lys Lys Lys Ile Tyr Leu Cys Glu Ser Val Leu Cys Ser 
    50                  55                  60                  


Phe Pro Arg Pro Arg Ser Trp Asn Ser Leu 
65                  70                  


<210> 3489
<211> 75
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<400> 3489
Met Ala Glu Glu Pro Gln Ser Val Leu Gln Leu Pro Xaa Ser Ile Ala 
1               5                   10                  15      


Ala Gly Gly Glu Gly Leu Xaa Asp Val Ser Pro Glu Xaa Xaa Xaa Pro 
            20                  25                  30          


Glu Pro Pro Ser Ser Ala Ala Val Ser Pro Gly Xaa Glu Glu Pro Ala 
        35                  40                  45              


Gly Asp Xaa Lys Lys Lys Asn Asp Ser Gly Leu Trp Pro Gly Ala Val 
    50                  55                  60                  


Ala His Ser Cys Asn Pro Ser Xaa Leu Val Gly 
65                  70                  75  


<210> 3490
<211> 56
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<400> 3490
Met Ala Glu Glu Pro Gln Ser Val Leu Gln Leu Pro Xaa Ser Ile Ala 
1               5                   10                  15      


Ala Gly Gly Glu Gly Leu Xaa Asp Val Ser Pro Glu Xaa Xaa Xaa Pro 
            20                  25                  30          


Glu Pro Pro Ser Ser Ala Ala Val Ser Pro Gly Xaa Glu Glu Pro Ala 
        35                  40                  45              


Gly Asp Xaa Lys Lys Lys Ser Asn 
    50                  55      


<210> 3491
<211> 59
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<400> 3491
Xaa Glu Pro Gln Ser Val Leu Gln Leu Pro Xaa Ser Ile Ala Ala Gly 
1               5                   10                  15      


Gly Glu Gly Leu Xaa Asp Val Ser Pro Glu Xaa Xaa Xaa Pro Glu Pro 
            20                  25                  30          


Pro Ser Ser Ala Ala Val Ser Pro Gly Xaa Glu Glu Pro Ala Gly Asp 
        35                  40                  45              


Xaa Lys Lys Lys Ile Gly Cys Glu Phe Xaa Pro 
    50                  55                  


<210> 3492
<211> 66
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<400> 3492
Xaa Ser Pro Ser Lys Met Ala Glu Glu Pro Gln Ser Val Leu Gln Leu 
1               5                   10                  15      


Pro Xaa Ser Ile Ala Ala Gly Gly Glu Gly Leu Xaa Asp Val Ser Pro 
            20                  25                  30          


Glu Xaa Xaa Xaa Pro Glu Pro Pro Ser Ser Ala Ala Val Ser Pro Gly 
        35                  40                  45              


Xaa Glu Glu Pro Ala Gly Asp Xaa Lys Lys Lys Ile Gly Cys Glu Phe 
    50                  55                  60                  


Xaa Pro 
65      


<210> 3493
<211> 153
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 3493
Met His Tyr Pro Ile Gly Leu Leu Phe Asp Leu Leu Ala Ser Ser Ser 
1               5                   10                  15      


Ala Leu Pro Trp Asn Ile Xaa Val His Phe Lys Ser Phe Pro Glu Lys 
            20                  25                  30          


Asp Leu Leu His Cys Pro Ser Lys Asp Ala Ile Glu Ala His Phe Met 
        35                  40                  45              


Ser Cys Met Lys Glu Ala Asp Ala Leu Lys His Lys Ser Gln Val Ile 
    50                  55                  60                  


Asn Glu Met Gln Lys Lys Asp His Lys Gln Leu Trp Met Gly Leu Gln 
65                  70                  75                  80  


Asn Asp Arg Phe Asp Gln Phe Trp Ala Ile Asn Arg Lys Leu Met Glu 
                85                  90                  95      


Tyr Pro Ala Glu Glu Asn Gly Phe Arg Tyr Ile Pro Phe Arg Ile Tyr 
            100                 105                 110         


Gln Xaa Xaa Xaa Glu Arg Pro Phe Ile Gln Lys Leu Phe Arg Pro Val 
        115                 120                 125             


Ala Ala Asp Gly Gln Leu His Xaa Leu Gly Asp Leu Leu Lys Glu Val 
    130                 135                 140                 


Cys Pro Ser Ala Ile Asp Pro Glu Asp 
145                 150             


<210> 3494
<211> 159
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 3494
Met His Tyr Pro Ile Gly Leu Leu Phe Asp Leu Leu Ala Ser Ser Ser 
1               5                   10                  15      


Ala Leu Pro Trp Asn Ile Xaa Val His Phe Lys Ser Phe Pro Glu Lys 
            20                  25                  30          


Asp Leu Leu His Cys Pro Ser Lys Asp Ala Ile Glu Ala His Phe Met 
        35                  40                  45              


Ser Cys Met Lys Glu Ala Asp Ala Leu Lys His Lys Ser Gln Val Ile 
    50                  55                  60                  


Asn Glu Met Gln Lys Lys Asp His Lys Gln Leu Trp Met Gly Leu Gln 
65                  70                  75                  80  


Asn Asp Arg Phe Asp Gln Phe Trp Ala Ile Asn Arg Lys Leu Met Glu 
                85                  90                  95      


Tyr Pro Ala Glu Glu Asn Gly Phe Arg Tyr Ile Pro Phe Arg Ile Tyr 
            100                 105                 110         


Gln Xaa Xaa Xaa Glu Arg Pro Phe Ile Gln Lys Leu Phe Arg Pro Val 
        115                 120                 125             


Ala Ala Asp Gly Gln Leu His Xaa Leu Gly Asp Leu Leu Lys Glu Val 
    130                 135                 140                 


Cys Pro Ser Ala Ile Asp Pro Glu Glu Ile Pro Pro Gly Glu Asp 
145                 150                 155                 


<210> 3495
<211> 44
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<400> 3495
Met Xaa Asp Asp Lys Asp Val Leu Arg Asp Val Trp Phe Gly Arg Ile 
1               5                   10                  15      


Pro Xaa Cys Phe Xaa Leu Tyr Gln Asp Glu Ile Xaa Glu Arg Glu Ala 
            20                  25                  30          


Glu Pro Tyr Tyr Ala Leu Ser Asn Trp Phe Ala Ile 
        35                  40                  


<210> 3496
<211> 162
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<400> 3496
Met Xaa Asp Asp Lys Asp Val Leu Arg Asp Val Trp Phe Gly Arg Ile 
1               5                   10                  15      


Pro Xaa Cys Phe Xaa Leu Tyr Gln Asp Glu Ile Xaa Glu Arg Glu Ala 
            20                  25                  30          


Glu Pro Tyr Tyr Leu Leu Leu Pro Arg Val Ser Tyr Leu Xaa Leu Val 
        35                  40                  45              


Xaa Asp Lys Val Lys Lys His Phe Gln Lys Val Met Arg Gln Glu Asp 
    50                  55                  60                  


Ile Ser Glu Ile Trp Phe Glu Tyr Glu Gly Xaa Pro Leu Lys Trp His 
65                  70                  75                  80  


Tyr Pro Ile Gly Leu Leu Phe Asp Leu Leu Ala Ser Ser Ser Ala Leu 
                85                  90                  95      


Pro Trp Asn Ile Xaa Val His Phe Lys Ser Phe Pro Glu Lys Asp Leu 
            100                 105                 110         


Leu His Cys Pro Ser Lys Asp Ala Ile Glu Ala His Phe Met Ser Cys 
        115                 120                 125             


Met Lys Glu Ala Asp Ala Leu Lys His Lys Ser Gln Val Ile Asn Glu 
    130                 135                 140                 


Met Gln Lys Lys Asp His Lys Gln Leu Trp Met Gly Leu Gln Asn Asp 
145                 150                 155                 160 


Asn Asp 
        


<210> 3497
<211> 275
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<400> 3497
Met Xaa Asp Asp Lys Asp Val Leu Arg Asp Val Trp Phe Gly Arg Ile 
1               5                   10                  15      


Pro Xaa Cys Phe Xaa Leu Tyr Gln Asp Glu Ile Xaa Glu Arg Glu Ala 
            20                  25                  30          


Glu Pro Tyr Tyr Leu Leu Leu Pro Arg Val Ser Tyr Leu Xaa Leu Val 
        35                  40                  45              


Xaa Asp Lys Val Lys Lys His Phe Gln Lys Val Met Arg Gln Glu Asp 
    50                  55                  60                  


Ile Ser Glu Ile Trp Phe Glu Tyr Glu Gly Xaa Pro Leu Lys Trp His 
65                  70                  75                  80  


Tyr Pro Ile Gly Leu Leu Phe Asp Leu Leu Ala Ser Ser Ser Ala Leu 
                85                  90                  95      


Pro Trp Asn Ile Xaa Val His Phe Lys Ser Phe Pro Glu Lys Asp Leu 
            100                 105                 110         


Leu His Cys Pro Ser Lys Asp Ala Ile Glu Ala His Phe Met Ser Cys 
        115                 120                 125             


Met Lys Glu Ala Asp Ala Leu Lys His Lys Ser Gln Val Ile Asn Glu 
    130                 135                 140                 


Met Gln Lys Lys Asp His Lys Gln Leu Trp Met Gly Leu Gln Asn Asp 
145                 150                 155                 160 


Arg Phe Asp Gln Phe Trp Ala Ile Asn Arg Lys Leu Met Glu Tyr Pro 
                165                 170                 175     


Ala Glu Glu Asn Gly Phe Arg Tyr Ile Pro Phe Arg Ile Tyr Gln Xaa 
            180                 185                 190         


Xaa Xaa Glu Arg Pro Phe Ile Gln Lys Leu Phe Arg Pro Val Ala Ala 
        195                 200                 205             


Asp Gly Gln Leu His Xaa Leu Gly Asp Leu Leu Lys Glu Val Cys Pro 
    210                 215                 220                 


Ser Ala Ile Asp Pro Glu Asp Gly Glu Lys Lys Asn Gln Val Met Ile 
225                 230                 235                 240 


His Gly Ile Glu Pro Met Leu Glu Xaa Pro Leu Gln Trp Leu Ser Glu 
                245                 250                 255     


His Leu Ser Tyr Pro Asp Asn Phe Leu His Ile Ser Ile Ile Pro Gln 
            260                 265                 270         


Pro Xaa Asp 
        275 


<210> 3498
<211> 91
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<400> 3498
Met Xaa Asp Asp Lys Asp Val Leu Arg Asp Val Trp Phe Gly Arg Ile 
1               5                   10                  15      


Pro Xaa Cys Phe Xaa Leu Tyr Gln Asp Glu Ile Xaa Glu Arg Glu Ala 
            20                  25                  30          


Glu Pro Tyr Tyr Xaa Asp Leu Xaa Ser Phe Gly Pro Ser Ile Gly Asn 
        35                  40                  45              


Ser Trp Asn Ile Leu Gln Lys Lys Met Asp Phe Val Ile Ser Pro Leu 
    50                  55                  60                  


Glu Tyr Ile Arg Gln Arg Leu Lys Asp Leu Ser Phe Arg Ser Cys Phe 
65                  70                  75                  80  


Val Leu Trp Leu Gln Met Asp Ser Cys Xaa His 
                85                  90      


<210> 3499
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<400> 3499
Ile Asp His Leu Phe Ile Ser Asn Leu Pro Glu Ile Val Val Glu Leu 
1               5                   10                  15      


Leu Met Xaa Leu His Glu Pro Ala Asn Ser Ser Ala Ser Gln Ser Xaa 
            20                  25                  30          


Asp Leu Cys Asp Phe Ser Gly Asp Leu Asp Pro Ala Pro Asn Pro Pro 
        35                  40                  45              


His Phe Pro Ser His Val Ile Lys Ala Xaa Phe Ala Tyr Ile Ser Asn 
    50                  55                  60                  


Cys His Lys Xaa Lys Leu Lys Ser Ile Leu Glu Ile Leu Ser Lys Ser 
65                  70                  75                  80  


Pro Asp Ser Tyr Gln Lys Ile Leu Leu Ala Ile Cys Glu Gln Ala Ala 
                85                  90                  95      


Glu Xaa Asn Asn Val Tyr Lys Lys His Arg Ile Leu Lys Ile Tyr His 
            100                 105                 110         


Leu Phe Val Ser Leu Leu Leu Lys Asp Ile Lys Ser Gly Leu Gly Gly 
        115                 120                 125             


Ala Trp Ala Phe Val Leu Arg Asp Val Ile Tyr Xaa Leu Ile His Tyr 
    130                 135                 140                 


Ile Asn Gln Arg Lys Leu Xaa Ile Phe Ser Gln 
145                 150                 155 


<210> 3500
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 3500
Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Xaa Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Xaa Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Xaa Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Xaa Gln Ala Ser Arg Gln Lys Lys 
                85                  90              


<210> 3501
<211> 154
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<400> 3501
Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Xaa Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Xaa Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Xaa Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Xaa Gln Ala Ser Arg Gln Lys Lys Met Gln Glu 
                85                  90                  95      


Ile Ser Ser Leu Val Lys Tyr Phe Ile Lys Cys Ala Asn Arg Lys Leu 
            100                 105                 110         


Phe Ser Val Tyr Phe Arg Leu Tyr Leu Lys Pro Ser Gln Asp Val His 
        115                 120                 125             


Arg Val Leu Val Ala Arg Ile Ile His Ala Val Xaa Lys Gly Cys Cys 
    130                 135                 140                 


Ser Gln Xaa Asp Gly Leu Asn Ser Lys Phe 
145                 150                 


<210> 3502
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 3502
Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Xaa Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Xaa Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Xaa Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Xaa Gln Ala Ser Arg Gln Lys Lys Met Gln Glu 
                85                  90                  95      


Ile Ser Ser Leu Val Lys Tyr Phe Ile Lys Cys Ala Asn Arg Arg Ala 
            100                 105                 110         


Pro Arg Leu Lys Cys Gln Glu Leu Leu Asn Tyr Ile Met Asp Xaa Val 
        115                 120                 125             


Lys Asp Ser Ser Asn Gly Ala 
    130                 135 


<210> 3503
<211> 1369
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1200)..(1200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1314)..(1314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1316)..(1316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1363)..(1363)
<223> Selenocysteine

<400> 3503
Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Xaa Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Xaa Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Xaa Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Xaa Gln Ala Ser Arg Gln Lys Lys Met Gln Glu 
                85                  90                  95      


Ile Ser Ser Leu Val Lys Tyr Phe Ile Lys Cys Ala Asn Arg Arg Ala 
            100                 105                 110         


Pro Arg Leu Lys Cys Gln Glu Leu Leu Asn Tyr Ile Met Asp Xaa Val 
        115                 120                 125             


Lys Asp Ser Ser Asn Gly Ala Ile Tyr Gly Ala Asp Cys Ser Asn Ile 
    130                 135                 140                 


Leu Leu Lys Asp Ile Leu Ser Val Arg Lys Tyr Trp Cys Glu Ile Ser 
145                 150                 155                 160 


Gln Gln Gln Trp Leu Glu Leu Phe Ser Val Tyr Phe Arg Leu Tyr Leu 
                165                 170                 175     


Lys Pro Ser Gln Asp Val His Arg Val Leu Val Ala Arg Ile Ile His 
            180                 185                 190         


Ala Val Xaa Lys Gly Cys Cys Ser Gln Xaa Asp Gly Leu Asn Ser Lys 
        195                 200                 205             


Phe Leu Asp Phe Phe Ser Lys Ala Ile Gln Cys Ala Arg Gln Glu Lys 
    210                 215                 220                 


Ser Ser Ser Gly Leu Asn His Ile Leu Ala Ala Leu Xaa Ile Phe Leu 
225                 230                 235                 240 


Lys Xaa Leu Ala Val Asn Phe Arg Ile Arg Val Cys Glu Leu Gly Asp 
                245                 250                 255     


Glu Ile Leu Pro Xaa Leu Leu Tyr Ile Trp Xaa Gln His Arg Leu Asn 
            260                 265                 270         


Asp Ser Leu Lys Glu Val Ile Ile Glu Leu Phe Gln Leu Gln Ile Tyr 
        275                 280                 285             


Ile His His Pro Lys Gly Ala Lys Xaa Gln Glu Lys Gly Ala Tyr Glu 
    290                 295                 300                 


Ser Xaa Lys Trp Arg Ser Ile Leu Tyr Asn Leu Tyr Asp Leu Leu Val 
305                 310                 315                 320 


Asn Glu Ile Ser His Ile Gly Ser Arg Gly Lys Tyr Ser Ser Gly Phe 
                325                 330                 335     


Arg Asn Ile Ala Val Lys Glu Asn Leu Ile Glu Leu Met Ala Asp Ile 
            340                 345                 350         


Cys His Gln Val Phe Asn Glu Asp Xaa Arg Ser Leu Glu Ile Ser Gln 
        355                 360                 365             


Ser Tyr Xaa Xaa Xaa Gln Arg Glu Ser Ser Asp Tyr Ser Val Pro Cys 
    370                 375                 380                 


Lys Arg Lys Lys Ile Glu Leu Gly Trp Glu Val Ile Lys Asp His Leu 
385                 390                 395                 400 


Gln Lys Ser Gln Asn Asp Phe Asp Leu Val Pro Trp Leu Gln Ile Ala 
                405                 410                 415     


Xaa Gln Leu Ile Ser Lys Tyr Pro Ala Ser Leu Pro Asn Cys Glu Leu 
            420                 425                 430         


Ser Pro Leu Leu Met Ile Leu Ser Gln Leu Leu Pro Gln Gln Arg His 
        435                 440                 445             


Gly Glu Arg Xaa Pro Tyr Val Leu Arg Cys Leu Xaa Glu Val Ala Leu 
    450                 455                 460                 


Cys Gln Asp Lys Arg Ser Asn Leu Glu Ser Ser Gln Lys Ser Asp Leu 
465                 470                 475                 480 


Leu Lys Leu Trp Asn Lys Ile Trp Cys Ile Xaa Phe Arg Gly Ile Ser 
                485                 490                 495     


Ser Glu Gln Ile Gln Ala Glu Asn Phe Gly Leu Leu Gly Ala Ile Ile 
            500                 505                 510         


Gln Gly Ser Leu Val Glu Val Asp Arg Glu Phe Trp Lys Leu Phe Xaa 
        515                 520                 525             


Gly Ser Ala Cys Arg Pro Ser Cys Pro Ala Val Cys Cys Leu Xaa Leu 
    530                 535                 540                 


Ala Leu Xaa Xaa Ser Ile Val Pro Gly Xaa Val Lys Met Gly Ile Glu 
545                 550                 555                 560 


Gln Asn Met Cys Glu Val Asn Arg Ser Phe Ser Leu Lys Glu Ser Ile 
                565                 570                 575     


Met Lys Trp Leu Leu Phe Tyr Gln Leu Glu Gly Asp Leu Glu Asn Ser 
            580                 585                 590         


Xaa Glu Val Pro Pro Ile Leu His Ser Asn Phe Pro His Leu Val Leu 
        595                 600                 605             


Glu Lys Ile Leu Val Ser Leu Xaa Met Lys Asn Cys Lys Ala Ala Met 
    610                 615                 620                 


Asn Phe Phe Gln Ser Val Pro Glu Cys Glu His His Gln Lys Asp Lys 
625                 630                 635                 640 


Glu Glu Leu Ser Phe Ser Glu Val Glu Glu Leu Phe Leu Gln Xaa Xaa 
                645                 650                 655     


Phe Asp Lys Met Asp Phe Leu Xaa Ile Val Arg Glu Cys Gly Ile Glu 
            660                 665                 670         


Lys His Gln Ser Ser Ile Gly Phe Ser Val His Gln Asn Leu Lys Glu 
        675                 680                 685             


Ser Leu Asp Arg Cys Leu Leu Gly Leu Ser Glu Gln Leu Leu Asn Asn 
    690                 695                 700                 


Tyr Ser Ser Glu Ile Xaa Asn Ser Glu Xaa Leu Val Arg Cys Ser Arg 
705                 710                 715                 720 


Leu Leu Val Gly Val Leu Gly Cys Tyr Cys Tyr Met Gly Val Ile Ala 
                725                 730                 735     


Glu Glu Glu Ala Tyr Lys Ser Glu Leu Phe Gln Lys Ala Lys Ser Leu 
            740                 745                 750         


Met Gln Cys Ala Gly Glu Ser Ile Xaa Leu Phe Lys Asn Lys Xaa Asn 
        755                 760                 765             


Glu Glu Phe Arg Ile Gly Ser Leu Arg Asn Met Met Gln Leu Cys Xaa 
    770                 775                 780                 


Arg Cys Leu Ser Asn Cys Xaa Lys Lys Ser Pro Asn Lys Ile Ala Ser 
785                 790                 795                 800 


Gly Phe Phe Leu Arg Leu Leu Xaa Ser Lys Leu Met Asn Asp Ile Ala 
                805                 810                 815     


Asp Ile Cys Lys Ser Leu Ala Ser Phe Ile Lys Lys Pro Phe Asp Arg 
            820                 825                 830         


Gly Glu Val Glu Ser Met Glu Asp Asp Xaa Asn Gly Asn Leu Met Glu 
        835                 840                 845             


Val Glu Asp Gln Ser Ser Met Asn Leu Phe Asn Asp Tyr Pro Asp Ser 
    850                 855                 860                 


Ser Val Ser Asp Ala Asn Glu Pro Gly Glu Ser Gln Ser Xaa Ile Gly 
865                 870                 875                 880 


Ala Ile Asn Pro Leu Ala Glu Glu Tyr Leu Ser Lys Gln Asp Leu Leu 
                885                 890                 895     


Phe Leu Asp Met Leu Lys Phe Leu Cys Leu Cys Val Xaa Xaa Ala Gln 
            900                 905                 910         


Xaa Asn Xaa Val Ser Phe Arg Ala Ala Asp Ile Arg Arg Lys Leu Leu 
        915                 920                 925             


Met Leu Ile Asp Ser Ser Xaa Leu Glu Pro Xaa Lys Ser Leu His Leu 
    930                 935                 940                 


His Met Tyr Leu Met Leu Leu Lys Glu Leu Pro Gly Glu Glu Tyr Pro 
945                 950                 955                 960 


Leu Pro Met Glu Asp Val Leu Glu Leu Leu Lys Pro Leu Ser Asn Val 
                965                 970                 975     


Cys Ser Leu Tyr Arg Arg Asp Gln Asp Val Cys Lys Xaa Ile Leu Asn 
            980                 985                 990         


His Val Leu His Val Val Lys Asn  Leu Gly Gln Ser Asn  Met Asp Ser 
        995                 1000                 1005             


Glu Asn  Xaa Arg Asp Ala Gln  Gly Gln Phe Leu Xaa  Val Ile Gly 
    1010                 1015                 1020             


Ala Phe  Trp His Leu Xaa Lys  Glu Arg Lys Tyr Ile  Phe Ser Val 
    1025                 1030                 1035             


Arg Met  Ala Leu Val Asn Cys  Leu Lys Xaa Leu Leu  Glu Ala Asp 
    1040                 1045                 1050             


Pro Tyr  Ser Lys Trp Ala Ile  Leu Asn Val Met Gly  Lys Asp Phe 
    1055                 1060                 1065             


Pro Val  Asn Glu Val Phe Xaa  Gln Phe Leu Ala Asp  Asn His His 
    1070                 1075                 1080             


Gln Val  Arg Met Leu Ala Ala  Glu Ser Ile Asn Arg  Leu Phe Gln 
    1085                 1090                 1095             


Asp Xaa  Lys Gly Asp Ser Ser  Arg Leu Leu Lys Ala  Leu Pro Leu 
    1100                 1105                 1110             


Lys Leu  Gln Gln Xaa Ala Phe  Glu Asn Ala Tyr Leu  Lys Ala Gln 
    1115                 1120                 1125             


Glu Gly  Met Arg Glu Met Ser  His Ser Ala Glu Asn  Pro Glu Xaa 
    1130                 1135                 1140             


Leu Asp  Glu Ile Tyr Asn Arg  Lys Ser Val Leu Leu  Xaa Leu Ile 
    1145                 1150                 1155             


Ala Val  Val Leu Ser Cys Ser  Pro Ile Cys Glu Lys  Gln Ala Leu 
    1160                 1165                 1170             


Phe Ala  Leu Cys Lys Ser Val  Lys Glu Asn Gly Leu  Glu Pro His 
    1175                 1180                 1185             


Leu Val  Lys Lys Val Leu Glu  Lys Val Ser Glu Xaa  Phe Gly Tyr 
    1190                 1195                 1200             


Arg Arg  Leu Glu Asp Phe Met  Ala Ser His Leu Asp  Tyr Leu Val 
    1205                 1210                 1215             


Leu Glu  Trp Leu Asn Leu Gln  Asp Xaa Glu Tyr Asn  Leu Ser Ser 
    1220                 1225                 1230             


Phe Pro  Phe Ile Leu Leu Asn  Tyr Xaa Asn Ile Glu  Asp Phe Tyr 
    1235                 1240                 1245             


Arg Ser  Cys Tyr Lys Val Leu  Ile Pro His Leu Val  Ile Arg Ser 
    1250                 1255                 1260             


His Phe  Asp Glu Val Lys Ser  Ile Ala Asn Gln Ile  Gln Glu Asp 
    1265                 1270                 1275             


Trp Lys  Ser Leu Leu Xaa Asp  Cys Phe Pro Lys Ile  Leu Val Asn 
    1280                 1285                 1290             


Ile Leu  Pro Tyr Phe Ala Tyr  Glu Gly Xaa Arg Asp  Ser Gly Met 
    1295                 1300                 1305             


Ala Gln  Gln Arg Glu Xaa Ala  Xaa Lys Val Tyr Asp  Met Leu Lys 
    1310                 1315                 1320             


Ser Glu  Asn Leu Leu Gly Lys  Gln Ile Asp His Leu  Phe Ile Ser 
    1325                 1330                 1335             


Asn Leu  Pro Glu Ile Val Val  Glu Leu Leu Met Xaa  Leu His Glu 
    1340                 1345                 1350             


Pro Ala  Asn Ser Ser Ala Ser  Gln Ser Xaa Asp Leu  Cys Asp Phe 
    1355                 1360                 1365             


Ser 
    


<210> 3504
<211> 3056
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1200)..(1200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1314)..(1314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1316)..(1316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1363)..(1363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1399)..(1399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1429)..(1429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1471)..(1471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1504)..(1504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1507)..(1507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1523)..(1523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1558)..(1558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1577)..(1577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1662)..(1662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1685)..(1685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1697)..(1697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1711)..(1711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1716)..(1716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1735)..(1735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1743)..(1743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1745)..(1745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1756)..(1757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1769)..(1769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1808)..(1808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1810)..(1810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1819)..(1819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1835)..(1835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1840)..(1840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1854)..(1854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1864)..(1864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1871)..(1871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1880)..(1880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1884)..(1885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1908)..(1908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1926)..(1926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1953)..(1953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1984)..(1985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1997)..(1997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2031)..(2031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2035)..(2035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2048)..(2048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2053)..(2053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2059)..(2059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2113)..(2113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2122)..(2122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2142)..(2142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2172)..(2172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2194)..(2194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2228)..(2228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2252)..(2252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2264)..(2264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2268)..(2268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2333)..(2333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2335)..(2335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2348)..(2348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2359)..(2359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2396)..(2396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2434)..(2434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2438)..(2438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2513)..(2513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2529)..(2529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2556)..(2556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2573)..(2573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2584)..(2584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2599)..(2599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2608)..(2608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2636)..(2636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2640)..(2640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2654)..(2654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2666)..(2666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2674)..(2674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2682)..(2682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2737)..(2737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2743)..(2743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2745)..(2745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2751)..(2751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2754)..(2754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2771)..(2771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2773)..(2773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2853)..(2853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2858)..(2858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2902)..(2902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2905)..(2905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2911)..(2911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2921)..(2921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2934)..(2934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2944)..(2944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2947)..(2947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2961)..(2961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2978)..(2978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2983)..(2983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3024)..(3024)
<223> Selenocysteine

<400> 3504
Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Xaa Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Xaa Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Xaa Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Xaa Gln Ala Ser Arg Gln Lys Lys Met Gln Glu 
                85                  90                  95      


Ile Ser Ser Leu Val Lys Tyr Phe Ile Lys Cys Ala Asn Arg Arg Ala 
            100                 105                 110         


Pro Arg Leu Lys Cys Gln Glu Leu Leu Asn Tyr Ile Met Asp Xaa Val 
        115                 120                 125             


Lys Asp Ser Ser Asn Gly Ala Ile Tyr Gly Ala Asp Cys Ser Asn Ile 
    130                 135                 140                 


Leu Leu Lys Asp Ile Leu Ser Val Arg Lys Tyr Trp Cys Glu Ile Ser 
145                 150                 155                 160 


Gln Gln Gln Trp Leu Glu Leu Phe Ser Val Tyr Phe Arg Leu Tyr Leu 
                165                 170                 175     


Lys Pro Ser Gln Asp Val His Arg Val Leu Val Ala Arg Ile Ile His 
            180                 185                 190         


Ala Val Xaa Lys Gly Cys Cys Ser Gln Xaa Asp Gly Leu Asn Ser Lys 
        195                 200                 205             


Phe Leu Asp Phe Phe Ser Lys Ala Ile Gln Cys Ala Arg Gln Glu Lys 
    210                 215                 220                 


Ser Ser Ser Gly Leu Asn His Ile Leu Ala Ala Leu Xaa Ile Phe Leu 
225                 230                 235                 240 


Lys Xaa Leu Ala Val Asn Phe Arg Ile Arg Val Cys Glu Leu Gly Asp 
                245                 250                 255     


Glu Ile Leu Pro Xaa Leu Leu Tyr Ile Trp Xaa Gln His Arg Leu Asn 
            260                 265                 270         


Asp Ser Leu Lys Glu Val Ile Ile Glu Leu Phe Gln Leu Gln Ile Tyr 
        275                 280                 285             


Ile His His Pro Lys Gly Ala Lys Xaa Gln Glu Lys Gly Ala Tyr Glu 
    290                 295                 300                 


Ser Xaa Lys Trp Arg Ser Ile Leu Tyr Asn Leu Tyr Asp Leu Leu Val 
305                 310                 315                 320 


Asn Glu Ile Ser His Ile Gly Ser Arg Gly Lys Tyr Ser Ser Gly Phe 
                325                 330                 335     


Arg Asn Ile Ala Val Lys Glu Asn Leu Ile Glu Leu Met Ala Asp Ile 
            340                 345                 350         


Cys His Gln Val Phe Asn Glu Asp Xaa Arg Ser Leu Glu Ile Ser Gln 
        355                 360                 365             


Ser Tyr Xaa Xaa Xaa Gln Arg Glu Ser Ser Asp Tyr Ser Val Pro Cys 
    370                 375                 380                 


Lys Arg Lys Lys Ile Glu Leu Gly Trp Glu Val Ile Lys Asp His Leu 
385                 390                 395                 400 


Gln Lys Ser Gln Asn Asp Phe Asp Leu Val Pro Trp Leu Gln Ile Ala 
                405                 410                 415     


Xaa Gln Leu Ile Ser Lys Tyr Pro Ala Ser Leu Pro Asn Cys Glu Leu 
            420                 425                 430         


Ser Pro Leu Leu Met Ile Leu Ser Gln Leu Leu Pro Gln Gln Arg His 
        435                 440                 445             


Gly Glu Arg Xaa Pro Tyr Val Leu Arg Cys Leu Xaa Glu Val Ala Leu 
    450                 455                 460                 


Cys Gln Asp Lys Arg Ser Asn Leu Glu Ser Ser Gln Lys Ser Asp Leu 
465                 470                 475                 480 


Leu Lys Leu Trp Asn Lys Ile Trp Cys Ile Xaa Phe Arg Gly Ile Ser 
                485                 490                 495     


Ser Glu Gln Ile Gln Ala Glu Asn Phe Gly Leu Leu Gly Ala Ile Ile 
            500                 505                 510         


Gln Gly Ser Leu Val Glu Val Asp Arg Glu Phe Trp Lys Leu Phe Xaa 
        515                 520                 525             


Gly Ser Ala Cys Arg Pro Ser Cys Pro Ala Val Cys Cys Leu Xaa Leu 
    530                 535                 540                 


Ala Leu Xaa Xaa Ser Ile Val Pro Gly Xaa Val Lys Met Gly Ile Glu 
545                 550                 555                 560 


Gln Asn Met Cys Glu Val Asn Arg Ser Phe Ser Leu Lys Glu Ser Ile 
                565                 570                 575     


Met Lys Trp Leu Leu Phe Tyr Gln Leu Glu Gly Asp Leu Glu Asn Ser 
            580                 585                 590         


Xaa Glu Val Pro Pro Ile Leu His Ser Asn Phe Pro His Leu Val Leu 
        595                 600                 605             


Glu Lys Ile Leu Val Ser Leu Xaa Met Lys Asn Cys Lys Ala Ala Met 
    610                 615                 620                 


Asn Phe Phe Gln Ser Val Pro Glu Cys Glu His His Gln Lys Asp Lys 
625                 630                 635                 640 


Glu Glu Leu Ser Phe Ser Glu Val Glu Glu Leu Phe Leu Gln Xaa Xaa 
                645                 650                 655     


Phe Asp Lys Met Asp Phe Leu Xaa Ile Val Arg Glu Cys Gly Ile Glu 
            660                 665                 670         


Lys His Gln Ser Ser Ile Gly Phe Ser Val His Gln Asn Leu Lys Glu 
        675                 680                 685             


Ser Leu Asp Arg Cys Leu Leu Gly Leu Ser Glu Gln Leu Leu Asn Asn 
    690                 695                 700                 


Tyr Ser Ser Glu Ile Xaa Asn Ser Glu Xaa Leu Val Arg Cys Ser Arg 
705                 710                 715                 720 


Leu Leu Val Gly Val Leu Gly Cys Tyr Cys Tyr Met Gly Val Ile Ala 
                725                 730                 735     


Glu Glu Glu Ala Tyr Lys Ser Glu Leu Phe Gln Lys Ala Lys Ser Leu 
            740                 745                 750         


Met Gln Cys Ala Gly Glu Ser Ile Xaa Leu Phe Lys Asn Lys Xaa Asn 
        755                 760                 765             


Glu Glu Phe Arg Ile Gly Ser Leu Arg Asn Met Met Gln Leu Cys Xaa 
    770                 775                 780                 


Arg Cys Leu Ser Asn Cys Xaa Lys Lys Ser Pro Asn Lys Ile Ala Ser 
785                 790                 795                 800 


Gly Phe Phe Leu Arg Leu Leu Xaa Ser Lys Leu Met Asn Asp Ile Ala 
                805                 810                 815     


Asp Ile Cys Lys Ser Leu Ala Ser Phe Ile Lys Lys Pro Phe Asp Arg 
            820                 825                 830         


Gly Glu Val Glu Ser Met Glu Asp Asp Xaa Asn Gly Asn Leu Met Glu 
        835                 840                 845             


Val Glu Asp Gln Ser Ser Met Asn Leu Phe Asn Asp Tyr Pro Asp Ser 
    850                 855                 860                 


Ser Val Ser Asp Ala Asn Glu Pro Gly Glu Ser Gln Ser Xaa Ile Gly 
865                 870                 875                 880 


Ala Ile Asn Pro Leu Ala Glu Glu Tyr Leu Ser Lys Gln Asp Leu Leu 
                885                 890                 895     


Phe Leu Asp Met Leu Lys Phe Leu Cys Leu Cys Val Xaa Xaa Ala Gln 
            900                 905                 910         


Xaa Asn Xaa Val Ser Phe Arg Ala Ala Asp Ile Arg Arg Lys Leu Leu 
        915                 920                 925             


Met Leu Ile Asp Ser Ser Xaa Leu Glu Pro Xaa Lys Ser Leu His Leu 
    930                 935                 940                 


His Met Tyr Leu Met Leu Leu Lys Glu Leu Pro Gly Glu Glu Tyr Pro 
945                 950                 955                 960 


Leu Pro Met Glu Asp Val Leu Glu Leu Leu Lys Pro Leu Ser Asn Val 
                965                 970                 975     


Cys Ser Leu Tyr Arg Arg Asp Gln Asp Val Cys Lys Xaa Ile Leu Asn 
            980                 985                 990         


His Val Leu His Val Val Lys Asn  Leu Gly Gln Ser Asn  Met Asp Ser 
        995                 1000                 1005             


Glu Asn  Xaa Arg Asp Ala Gln  Gly Gln Phe Leu Xaa  Val Ile Gly 
    1010                 1015                 1020             


Ala Phe  Trp His Leu Xaa Lys  Glu Arg Lys Tyr Ile  Phe Ser Val 
    1025                 1030                 1035             


Arg Met  Ala Leu Val Asn Cys  Leu Lys Xaa Leu Leu  Glu Ala Asp 
    1040                 1045                 1050             


Pro Tyr  Ser Lys Trp Ala Ile  Leu Asn Val Met Gly  Lys Asp Phe 
    1055                 1060                 1065             


Pro Val  Asn Glu Val Phe Xaa  Gln Phe Leu Ala Asp  Asn His His 
    1070                 1075                 1080             


Gln Val  Arg Met Leu Ala Ala  Glu Ser Ile Asn Arg  Leu Phe Gln 
    1085                 1090                 1095             


Asp Xaa  Lys Gly Asp Ser Ser  Arg Leu Leu Lys Ala  Leu Pro Leu 
    1100                 1105                 1110             


Lys Leu  Gln Gln Xaa Ala Phe  Glu Asn Ala Tyr Leu  Lys Ala Gln 
    1115                 1120                 1125             


Glu Gly  Met Arg Glu Met Ser  His Ser Ala Glu Asn  Pro Glu Xaa 
    1130                 1135                 1140             


Leu Asp  Glu Ile Tyr Asn Arg  Lys Ser Val Leu Leu  Xaa Leu Ile 
    1145                 1150                 1155             


Ala Val  Val Leu Ser Cys Ser  Pro Ile Cys Glu Lys  Gln Ala Leu 
    1160                 1165                 1170             


Phe Ala  Leu Cys Lys Ser Val  Lys Glu Asn Gly Leu  Glu Pro His 
    1175                 1180                 1185             


Leu Val  Lys Lys Val Leu Glu  Lys Val Ser Glu Xaa  Phe Gly Tyr 
    1190                 1195                 1200             


Arg Arg  Leu Glu Asp Phe Met  Ala Ser His Leu Asp  Tyr Leu Val 
    1205                 1210                 1215             


Leu Glu  Trp Leu Asn Leu Gln  Asp Xaa Glu Tyr Asn  Leu Ser Ser 
    1220                 1225                 1230             


Phe Pro  Phe Ile Leu Leu Asn  Tyr Xaa Asn Ile Glu  Asp Phe Tyr 
    1235                 1240                 1245             


Arg Ser  Cys Tyr Lys Val Leu  Ile Pro His Leu Val  Ile Arg Ser 
    1250                 1255                 1260             


His Phe  Asp Glu Val Lys Ser  Ile Ala Asn Gln Ile  Gln Glu Asp 
    1265                 1270                 1275             


Trp Lys  Ser Leu Leu Xaa Asp  Cys Phe Pro Lys Ile  Leu Val Asn 
    1280                 1285                 1290             


Ile Leu  Pro Tyr Phe Ala Tyr  Glu Gly Xaa Arg Asp  Ser Gly Met 
    1295                 1300                 1305             


Ala Gln  Gln Arg Glu Xaa Ala  Xaa Lys Val Tyr Asp  Met Leu Lys 
    1310                 1315                 1320             


Ser Glu  Asn Leu Leu Gly Lys  Gln Ile Asp His Leu  Phe Ile Ser 
    1325                 1330                 1335             


Asn Leu  Pro Glu Ile Val Val  Glu Leu Leu Met Xaa  Leu His Glu 
    1340                 1345                 1350             


Pro Ala  Asn Ser Ser Ala Ser  Gln Ser Xaa Asp Leu  Cys Asp Phe 
    1355                 1360                 1365             


Ser Gly  Asp Leu Asp Pro Ala  Pro Asn Pro Pro His  Phe Pro Ser 
    1370                 1375                 1380             


His Val  Ile Lys Ala Xaa Phe  Ala Tyr Ile Ser Asn  Cys His Lys 
    1385                 1390                 1395             


Xaa Lys  Leu Lys Ser Ile Leu  Glu Ile Leu Ser Lys  Ser Pro Asp 
    1400                 1405                 1410             


Ser Tyr  Gln Lys Ile Leu Leu  Ala Ile Cys Glu Gln  Ala Ala Glu 
    1415                 1420                 1425             


Xaa Asn  Asn Val Tyr Lys Lys  His Arg Ile Leu Lys  Ile Tyr His 
    1430                 1435                 1440             


Leu Phe  Val Ser Leu Leu Leu  Lys Asp Ile Lys Ser  Gly Leu Gly 
    1445                 1450                 1455             


Gly Ala  Trp Ala Phe Val Leu  Arg Asp Val Ile Tyr  Xaa Leu Ile 
    1460                 1465                 1470             


His Tyr  Ile Asn Gln Arg Pro  Ser Cys Ile Met Asp  Val Ser Leu 
    1475                 1480                 1485             


Arg Ser  Phe Ser Leu Cys Cys  Asp Leu Leu Ser Gln  Val Cys Gln 
    1490                 1495                 1500             


Xaa Ala  Val Xaa Tyr Cys Lys  Asp Ala Leu Glu Asn  His Leu His 
    1505                 1510                 1515             


Val Ile  Val Gly Xaa Leu Ile  Pro Leu Val Tyr Glu  Gln Val Glu 
    1520                 1525                 1530             


Val Gln  Lys Gln Val Leu Asp  Leu Leu Lys Tyr Leu  Val Ile Asp 
    1535                 1540                 1545             


Asn Lys  Asp Asn Glu Asn Leu  Tyr Ile Xaa Ile Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Phe  Pro Asp His Val Val  Phe Lys Asp Leu Arg  Ile Xaa Gln 
    1565                 1570                 1575             


Gln Lys  Ile Lys Tyr Ser Arg  Gly Pro Phe Ser Leu  Leu Glu Glu 
    1580                 1585                 1590             


Ile Asn  His Phe Leu Ser Val  Ser Val Tyr Asp Ala  Leu Pro Leu 
    1595                 1600                 1605             


Xaa Arg  Leu Glu Gly Leu Lys  Asp Leu Arg Arg Gln  Leu Glu Leu 
    1610                 1615                 1620             


His Lys  Asp Gln Met Val Asp  Ile Met Arg Ala Ser  Gln Asp Asn 
    1625                 1630                 1635             


Pro Gln  Asp Gly Ile Met Val  Lys Leu Val Val Asn  Leu Leu Gln 
    1640                 1645                 1650             


Leu Ser  Lys Met Ala Ile Asn  His Xaa Gly Glu Lys  Glu Val Leu 
    1655                 1660                 1665             


Glu Ala  Val Gly Ser Cys Leu  Gly Glu Val Gly Pro  Ile Asp Phe 
    1670                 1675                 1680             


Ser Xaa  Ile Ala Ile Gln His  Ser Lys Asp Ala Ser  Tyr Xaa Lys 
    1685                 1690                 1695             


Ala Leu  Lys Leu Phe Glu Asp  Lys Glu Leu Gln Trp  Xaa Phe Ile 
    1700                 1705                 1710             


Met Leu  Xaa Tyr Leu Asn Asn  Xaa Leu Val Glu Asp  Cys Val Lys 
    1715                 1720                 1725             


Val Arg  Ser Ala Ala Val Xaa  Cys Leu Lys Asn Ile  Leu Ala Xaa 
    1730                 1735                 1740             


Lys Xaa  Gly His Ser Phe Trp  Glu Ile Tyr Lys Met  Xaa Xaa Asp 
    1745                 1750                 1755             


Pro Met  Leu Ala Tyr Leu Gln  Pro Phe Arg Xaa Ser  Arg Lys Lys 
    1760                 1765                 1770             


Phe Leu  Glu Val Pro Arg Phe  Asp Lys Glu Asn Pro  Phe Glu Gly 
    1775                 1780                 1785             


Leu Asp  Asp Ile Asn Leu Trp  Ile Pro Leu Ser Glu  Asn His Asp 
    1790                 1795                 1800             


Ile Trp  Ile Lys Xaa Leu Xaa  Cys Ala Phe Leu Asp  Ser Gly Gly 
    1805                 1810                 1815             


Xaa Lys  Cys Glu Ile Leu Gln  Leu Leu Lys Pro Met  Cys Glu Val 
    1820                 1825                 1830             


Lys Xaa  Asp Phe Cys Gln Xaa  Val Leu Pro Tyr Leu  Ile His Asp 
    1835                 1840                 1845             


Ile Leu  Leu Gln Asp Xaa Asn  Glu Ser Trp Arg Asn  Leu Leu Ser 
    1850                 1855                 1860             


Xaa His  Val Gln Gly Phe Phe  Xaa Ser Cys Leu Arg  His Phe Ser 
    1865                 1870                 1875             


Gln Xaa  Ser Arg Ser Xaa Xaa  Pro Ala Asn Leu Asp  Ser Glu Ser 
    1880                 1885                 1890             


Glu His  Phe Phe Arg Cys Cys  Leu Asp Lys Lys Ser  Gln Arg Xaa 
    1895                 1900                 1905             


Met Leu  Ala Val Val Asp Tyr  Met Arg Arg Gln Lys  Arg Pro Ser 
    1910                 1915                 1920             


Ser Gly  Xaa Ile Phe Asn Asp  Ala Phe Trp Leu Asp  Leu Asn Tyr 
    1925                 1930                 1935             


Leu Glu  Val Ala Lys Val Ala  Gln Ser Cys Ala Ala  His Phe Xaa 
    1940                 1945                 1950             


Ala Leu  Leu Tyr Ala Glu Ile  Tyr Ala Asp Lys Lys  Ser Met Asp 
    1955                 1960                 1965             


Asp Gln  Glu Lys Arg Ser Leu  Ala Phe Glu Glu Gly  Ser Gln Ser 
    1970                 1975                 1980             


Xaa Xaa  Ile Ser Ser Leu Ser  Glu Lys Ser Lys Glu  Glu Xaa Gly 
    1985                 1990                 1995             


Ile Ser  Leu Gln Asp Leu Leu  Leu Glu Ile Tyr Arg  Ser Ile Gly 
    2000                 2005                 2010             


Glu Pro  Asp Ser Leu Tyr Gly  Cys Gly Gly Gly Lys  Met Leu Gln 
    2015                 2020                 2025             


Pro Ile  Xaa Arg Leu Arg Xaa  Tyr Glu His Glu Ala  Met Trp Gly 
    2030                 2035                 2040             


Lys Ala  Leu Val Xaa Tyr Asp  Leu Glu Xaa Ala Ile  Pro Ser Ser 
    2045                 2050                 2055             


Xaa Arg  Gln Ala Gly Ile Ile  Gln Ala Leu Gln Asn  Leu Gly Leu 
    2060                 2065                 2070             


Cys His  Ile Leu Ser Val Tyr  Leu Lys Gly Leu Asp  Tyr Glu Asn 
    2075                 2080                 2085             


Lys Asp  Trp Cys Pro Glu Leu  Glu Glu Leu His Tyr  Gln Ala Ala 
    2090                 2095                 2100             


Trp Arg  Asn Met Gln Trp Asp  His Cys Xaa Ser Val  Ser Lys Glu 
    2105                 2110                 2115             


Val Glu  Gly Xaa Ser Tyr His  Glu Ser Leu Tyr Asn  Ala Leu Gln 
    2120                 2125                 2130             


Ser Leu  Arg Asp Arg Glu Phe  Ser Xaa Phe Tyr Glu  Ser Leu Lys 
    2135                 2140                 2145             


Tyr Ala  Arg Val Lys Glu Val  Glu Glu Met Cys Lys  Arg Ser Leu 
    2150                 2155                 2160             


Glu Ser  Val Tyr Ser Leu Tyr  Pro Xaa Leu Ser Arg  Leu Gln Ala 
    2165                 2170                 2175             


Ile Gly  Glu Leu Glu Ser Ile  Gly Glu Leu Phe Ser  Arg Ser Val 
    2180                 2185                 2190             


Xaa His  Arg Gln Leu Ser Glu  Val Tyr Ile Lys Trp  Gln Lys His 
    2195                 2200                 2205             


Ser Gln  Leu Leu Lys Asp Ser  Asp Phe Ser Phe Gln  Glu Pro Ile 
    2210                 2215                 2220             


Met Ala  Leu Arg Xaa Val Ile  Leu Glu Ile Leu Met  Glu Lys Glu 
    2225                 2230                 2235             


Met Asp  Asn Ser Gln Arg Glu  Cys Ile Lys Asp Ile  Leu Xaa Lys 
    2240                 2245                 2250             


His Leu  Val Glu Leu Ser Ile  Leu Ala Arg Xaa Phe  Lys Asn Xaa 
    2255                 2260                 2265             


Gln Leu  Pro Glu Arg Ala Ile  Phe Gln Ile Lys Gln  Tyr Asn Ser 
    2270                 2275                 2280             


Val Ser  Cys Gly Val Ser Glu  Trp Gln Leu Glu Glu  Ala Gln Val 
    2285                 2290                 2295             


Phe Trp  Ala Lys Lys Glu Gln  Ser Leu Ala Leu Ser  Ile Leu Lys 
    2300                 2305                 2310             


Gln Met  Ile Lys Lys Leu Asp  Ala Ser Cys Ala Ala  Asn Asn Pro 
    2315                 2320                 2325             


Ser Leu  Lys Leu Xaa Tyr Xaa  Glu Cys Leu Arg Val  Cys Gly Asn 
    2330                 2335                 2340             


Trp Leu  Ala Glu Xaa Cys Leu  Glu Asn Pro Ala Val  Ile Met Gln 
    2345                 2350                 2355             


Xaa Tyr  Leu Glu Lys Ala Val  Glu Val Ala Gly Asn  Tyr Asp Gly 
    2360                 2365                 2370             


Glu Ser  Ser Asp Glu Leu Arg  Asn Gly Lys Met Lys  Ala Phe Leu 
    2375                 2380                 2385             


Ser Leu  Ala Arg Phe Ser Asp  Xaa Gln Tyr Gln Arg  Ile Glu Asn 
    2390                 2395                 2400             


Tyr Met  Lys Ser Ser Glu Phe  Glu Asn Lys Gln Ala  Leu Leu Lys 
    2405                 2410                 2415             


Arg Ala  Lys Glu Glu Val Gly  Leu Leu Arg Glu His  Lys Ile Gln 
    2420                 2425                 2430             


Xaa Asn  Arg Tyr Xaa Val Lys  Val Gln Arg Glu Leu  Glu Leu Asp 
    2435                 2440                 2445             


Glu Leu  Ala Leu Arg Ala Leu  Lys Glu Asp Arg Lys  Arg Phe Leu 
    2450                 2455                 2460             


Cys Lys  Ala Val Glu Asn Tyr  Ile Asn Cys Leu Leu  Ser Gly Glu 
    2465                 2470                 2475             


Glu His  Asp Met Trp Val Phe  Arg Leu Cys Ser Leu  Trp Leu Glu 
    2480                 2485                 2490             


Asn Ser  Gly Val Ser Glu Val  Asn Gly Met Met Lys  Arg Asp Gly 
    2495                 2500                 2505             


Met Lys  Ile Pro Xaa Tyr Lys  Phe Leu Pro Leu Met  Tyr Gln Leu 
    2510                 2515                 2520             


Ala Ala  Arg Met Gly Xaa Lys  Met Met Gly Gly Leu  Gly Phe His 
    2525                 2530                 2535             


Glu Val  Leu Asn Asn Leu Ile  Ser Arg Ile Ser Met  Asp His Pro 
    2540                 2545                 2550             


His His  Xaa Leu Phe Ile Ile  Leu Ala Leu Ala Asn  Ala Asn Arg 
    2555                 2560                 2565             


Asp Glu  Phe Leu Xaa Lys Pro  Glu Val Ala Arg Arg  Ser Arg Ile 
    2570                 2575                 2580             


Xaa Lys  Asn Val Pro Lys Gln  Ser Ser Gln Leu Asp  Glu Asp Arg 
    2585                 2590                 2595             


Xaa Glu  Ala Ala Asn Arg Ile  Ile Cys Xaa Ile Arg  Ser Arg Arg 
    2600                 2605                 2610             


Pro Gln  Met Val Arg Ser Val  Glu Ala Leu Cys Asp  Ala Tyr Ile 
    2615                 2620                 2625             


Ile Leu  Ala Asn Leu Asp Ala  Xaa Gln Trp Lys Xaa  Gln Arg Lys 
    2630                 2635                 2640             


Gly Ile  Asn Ile Pro Ala Asp  Gln Pro Ile Xaa Lys  Leu Lys Asn 
    2645                 2650                 2655             


Leu Glu  Asp Val Val Val Pro  Xaa Met Glu Ile Lys  Val Asp His 
    2660                 2665                 2670             


Xaa Gly  Glu Tyr Gly Asn Leu  Val Xaa Ile Gln Ser  Phe Lys Ala 
    2675                 2680                 2685             


Glu Phe  Arg Leu Ala Gly Gly  Val Asn Leu Pro Lys  Ile Ile Asp 
    2690                 2695                 2700             


Cys Val  Gly Ser Asp Gly Lys  Glu Arg Arg Gln Leu  Val Lys Gly 
    2705                 2710                 2715             


Arg Asp  Asp Leu Arg Gln Asp  Ala Val Met Gln Gln  Val Phe Gln 
    2720                 2725                 2730             


Met Cys  Asn Xaa Leu Leu Gln  Arg Asn Xaa Glu Xaa  Arg Lys Arg 
    2735                 2740                 2745             


Lys Leu  Xaa Ile Cys Xaa Tyr  Lys Val Val Pro Leu  Ser Gln Arg 
    2750                 2755                 2760             


Ser Gly  Val Leu Glu Trp Cys  Xaa Gly Xaa Val Pro  Ile Gly Glu 
    2765                 2770                 2775             


Phe Leu  Val Asn Asn Glu Asp  Gly Ala His Lys Arg  Tyr Arg Pro 
    2780                 2785                 2790             


Asn Asp  Phe Ser Ala Phe Gln  Cys Gln Lys Lys Met  Met Glu Val 
    2795                 2800                 2805             


Gln Lys  Lys Ser Phe Glu Glu  Lys Tyr Glu Val Phe  Met Asp Val 
    2810                 2815                 2820             


Cys Gln  Asn Phe Gln Pro Val  Phe Arg Tyr Phe Cys  Met Glu Lys 
    2825                 2830                 2835             


Phe Leu  Asp Pro Ala Ile Trp  Phe Glu Lys Arg Leu  Ala Tyr Xaa 
    2840                 2845                 2850             


Arg Ser  Val Ala Xaa Ser Ser  Ile Val Gly Tyr Ile  Leu Gly Leu 
    2855                 2860                 2865             


Gly Asp  Arg His Val Gln Asn  Ile Leu Ile Asn Glu  Gln Ser Ala 
    2870                 2875                 2880             


Glu Leu  Val His Ile Asp Leu  Gly Val Ala Phe Glu  Gln Gly Lys 
    2885                 2890                 2895             


Ile Leu  Pro Xaa Pro Glu Xaa  Val Pro Phe Arg Leu  Xaa Arg Asp 
    2900                 2905                 2910             


Ile Val  Asp Gly Met Gly Ile  Xaa Gly Val Glu Gly  Val Phe Arg 
    2915                 2920                 2925             


Arg Cys  Cys Glu Lys Xaa Met  Glu Val Met Arg Asn  Ser Gln Glu 
    2930                 2935                 2940             


Xaa Leu  Leu Xaa Ile Val Glu  Val Leu Leu Tyr Asp  Pro Leu Phe 
    2945                 2950                 2955             


Asp Trp  Xaa Met Asn Pro Leu  Lys Ala Leu Tyr Leu  Gln Gln Arg 
    2960                 2965                 2970             


Pro Glu  Asp Glu Xaa Glu Leu  His Pro Xaa Leu Asn  Ala Asp Asp 
    2975                 2980                 2985             


Gln Glu  Cys Lys Arg Asn Leu  Ser Asp Ile Asp Gln  Ser Phe Asn 
    2990                 2995                 3000             


Lys Val  Ala Glu Arg Val Leu  Met Arg Leu Gln Glu  Lys Leu Lys 
    3005                 3010                 3015             


Gly Val  Glu Glu Gly Xaa Val  Leu Ser Val Gly Gly  Gln Val Asn 
    3020                 3025                 3030             


Leu Leu  Ile Gln Gln Ala Ile  Asp Pro Lys Asn Leu  Ser Arg Leu 
    3035                 3040                 3045             


Phe Pro  Gly Trp Lys Ala Trp  Val 
    3050                 3055     


<210> 3505
<211> 168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 3505
Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Xaa Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Xaa Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Xaa Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Xaa Gln Ala Ser Arg Gln Lys Lys Met Gln Glu 
                85                  90                  95      


Ile Ser Ser Leu Val Lys Tyr Phe Ile Lys Cys Ala Asn Arg Arg Ala 
            100                 105                 110         


Pro Arg Leu Lys Cys Gln Glu Leu Leu Asn Tyr Ile Met Asp Xaa Val 
        115                 120                 125             


Lys Asp Ser Ser Asn Gly Ala Ile Tyr Gly Ala Asp Cys Ser Asn Ile 
    130                 135                 140                 


Leu Leu Lys Asp Ile Leu Ser Val Arg Lys Tyr Trp Cys Glu Ile Ser 
145                 150                 155                 160 


Gln Gln Gln Trp Leu Gly Met Phe 
                165             


<210> 3506
<211> 112
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 3506
Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Xaa Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Xaa Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Xaa Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Xaa Gln Ala Ser Arg Gln Lys Lys Met Gln Glu 
                85                  90                  95      


Ile Ser Ser Leu Val Lys Tyr Phe Ile Lys Cys Ala Asn Arg Ser Lys 
            100                 105                 110         


<210> 3507
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<400> 3507
Xaa Cys Glu Val Lys Xaa Asp Phe Cys Gln Xaa Val Leu Pro Tyr Leu 
1               5                   10                  15      


Ile His Asp Ile Leu Leu Gln Asp Xaa Asn Glu Ser Trp Arg Asn Leu 
            20                  25                  30          


Leu Ser Xaa His Val Gln Gly Phe Phe Xaa Ser Cys Leu Arg His Phe 
        35                  40                  45              


Ser Gln Xaa Ser Arg Ser Xaa Xaa Pro Ala Asn Leu Asp Ser Asp Leu 
    50                  55                  60                  


Leu Gln Glu Gln Phe Leu Met Met Leu Ser Gly Trp Ile 
65                  70                  75          


<210> 3508
<211> 354
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<400> 3508
Met Ser Arg Leu Leu His Ala Glu Glu Trp Ala Glu Val Lys Glu Leu 
1               5                   10                  15      


Gly Asp His His Arg Gln Pro Gln Pro His His Leu Pro Gln Pro Pro 
            20                  25                  30          


Pro Pro Pro Gln Pro Pro Ala Xaa Leu Gln Ala Arg Glu His Pro Val 
        35                  40                  45              


Tyr Pro Pro Glu Leu Ser Leu Leu Asp Ser Xaa Asp Pro Arg Ala Trp 
    50                  55                  60                  


Leu Ala Pro Xaa Leu Gln Gly Ile Cys Xaa Ala Arg Ala Ala Gln Tyr 
65                  70                  75                  80  


Leu Leu His Ser Pro Glu Leu Gly Ala Ser Glu Ala Ala Ala Pro Arg 
                85                  90                  95      


Asp Glu Val Asp Gly Arg Gly Glu Leu Val Arg Arg Ser Ser Gly Gly 
            100                 105                 110         


Ala Ser Ser Ser Lys Ser Pro Gly Pro Val Lys Val Arg Glu Gln Leu 
        115                 120                 125             


Cys Lys Leu Lys Gly Gly Val Val Val Asp Glu Leu Gly Cys Ser Arg 
    130                 135                 140                 


Gln Arg Ala Pro Ser Ser Lys Gln Val Asn Gly Val Gln Lys Gln Arg 
145                 150                 155                 160 


Arg Leu Ala Ala Asn Ala Arg Glu Arg Arg Arg Met His Gly Leu Asn 
                165                 170                 175     


His Ala Phe Asp Gln Leu Arg Asn Val Ile Pro Ser Phe Asn Asn Asp 
            180                 185                 190         


Lys Lys Leu Ser Lys Tyr Glu Xaa Leu Gln Met Ala Gln Ile Tyr Ile 
        195                 200                 205             


Asn Ala Leu Ser Glu Leu Leu Gln Xaa Pro Ser Gly Gly Glu Gln Pro 
    210                 215                 220                 


Pro Pro Pro Pro Ala Ser Cys Lys Ser Asp His His His Leu Arg Xaa 
225                 230                 235                 240 


Ala Ala Ser Tyr Glu Gly Gly Ala Gly Asn Ala Xaa Ala Ala Gly Ala 
                245                 250                 255     


Gln Gln Ala Ser Gly Gly Ser Gln Arg Pro Xaa Pro Pro Gly Ser Cys 
            260                 265                 270         


Arg Xaa Arg Phe Ser Ala Pro Ala Ser Ala Gly Gly Tyr Ser Val Gln 
        275                 280                 285             


Leu Asp Ala Leu His Phe Ser Xaa Phe Glu Asp Ser Ala Leu Xaa Ala 
    290                 295                 300                 


Met Met Ala Gln Lys Asn Leu Ser Pro Ser Leu Pro Gly Ser Ile Leu 
305                 310                 315                 320 


Gln Pro Val Gln Glu Glu Asn Ser Lys Xaa Ser Pro Arg Ser His Arg 
                325                 330                 335     


Ser Asp Gly Glu Phe Ser Pro His Ser His Tyr Ser Asp Ser Asp Glu 
            340                 345                 350         


Ala Ser 
        


<210> 3509
<211> 152
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<400> 3509
Met Lys Ser Cys Lys Pro Ser Gly Pro Pro Ala Gly Ala Arg Val Ala 
1               5                   10                  15      


Pro Pro Cys Ala Gly Gly Xaa Glu Cys Ala Gly Xaa Cys Ala Gly Ala 
            20                  25                  30          


Gly Arg Leu Glu Ser Ala Ala Arg Arg Arg Leu Ala Ala Asn Ala Arg 
        35                  40                  45              


Glu Arg Arg Arg Met Gln Gly Leu Asn Xaa Ala Phe Asp Arg Leu Arg 
    50                  55                  60                  


Arg Val Val Pro Gln Trp Gly Gln Asp Lys Lys Leu Ser Lys Tyr Glu 
65                  70                  75                  80  


Xaa Leu Gln Met Ala Leu Ser Tyr Ile Met Ala Leu Xaa Arg Ile Leu 
                85                  90                  95      


Ala Glu Ala Glu Arg Phe Gly Ser Glu Arg Asp Trp Val Gly Leu His 
            100                 105                 110         


Cys Glu His Phe Gly Arg Asp His Tyr Leu Pro Phe Pro Gly Ala Lys 
        115                 120                 125             


Leu Pro Gly Glu Ser Glu Leu Tyr Ser Gln Arg Leu Phe Gly Phe Gln 
    130                 135                 140                 


Pro Glu Pro Phe Gln Met Ala Xaa 
145                 150         


<210> 3510
<211> 321
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<400> 3510
Met Lys His Ile Pro Val Leu Glu Asp Gly Pro Trp Lys Xaa Val Cys 
1               5                   10                  15      


Val Lys Glu Leu Asn Gly Leu Lys Lys Leu Lys Arg Lys Gly Lys Glu 
            20                  25                  30          


Pro Ala Arg Arg Ala Asn Gly Tyr Lys Xaa Phe Arg Leu Asp Leu Glu 
        35                  40                  45              


Ala Pro Glu Pro Arg Ala Val Ala Xaa Asn Gly Leu Arg Asp Arg Xaa 
    50                  55                  60                  


His Arg Leu Gln Pro Val Pro Val Pro Val Pro Val Pro Val Pro Val 
65                  70                  75                  80  


Ala Pro Ala Val Pro Pro Arg Gly Gly Xaa Asp Xaa Ala Gly Glu Arg 
                85                  90                  95      


Gly Gly Ser Arg Ala Pro Glu Val Ser Asp Ala Arg Lys Arg Cys Phe 
            100                 105                 110         


Ala Leu Gly Ala Val Gly Pro Gly Leu Pro Xaa Pro Pro Pro Pro Pro 
        115                 120                 125             


Pro Pro Ala Pro Gln Ser Gln Ala Pro Gly Gly Pro Glu Ala Gln Pro 
    130                 135                 140                 


Phe Arg Glu Pro Gly Leu Arg Pro Arg Ile Leu Leu Cys Ala Pro Pro 
145                 150                 155                 160 


Ala Arg Pro Ala Pro Ser Ala Pro Pro Ala Pro Pro Ala Pro Pro Glu 
                165                 170                 175     


Ser Xaa Val Arg Pro Ala Pro Pro Xaa Arg Pro Gly Glu Ser Ser Tyr 
            180                 185                 190         


Ser Ser Ile Ser His Val Ile Tyr Asn Asn His Gln Asp Ser Ser Ala 
        195                 200                 205             


Ser Pro Arg Lys Arg Pro Gly Glu Ala Xaa Ala Ala Ser Ser Glu Ile 
    210                 215                 220                 


Lys Ala Leu Gln Gln Xaa Arg Arg Leu Leu Ala Asn Ala Arg Glu Arg 
225                 230                 235                 240 


Xaa Arg Val His Xaa Ile Ser Ala Ala Phe Glu Ala Leu Arg Lys Gln 
                245                 250                 255     


Val Pro Cys Tyr Ser Tyr Gly Gln Lys Leu Ser Lys Leu Ala Ile Leu 
            260                 265                 270         


Arg Ile Ala Cys Asn Tyr Ile Leu Ser Leu Ala Arg Leu Ala Asp Leu 
        275                 280                 285             


Asp Tyr Ser Ala Asp His Ser Asn Leu Ser Phe Ser Glu Cys Val Gln 
    290                 295                 300                 


Arg Cys Xaa Arg Xaa Leu Gln Ala Glu Gly Arg Ala Lys Lys Arg Lys 
305                 310                 315                 320 


Glu 
    


<210> 3511
<211> 1013
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<400> 3511
Met Gly Asp Lys Lys Asp Asp Lys Asp Ser Pro Lys Lys Asn Lys Gly 
1               5                   10                  15      


Lys Glu Arg Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala Met Xaa 
            20                  25                  30          


Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn Xaa Asp 
        35                  40                  45              


Cys Val Gln Gly Leu Xaa His Ser Lys Ala Gln Glu Ile Leu Ala Arg 
    50                  55                  60                  


Asp Gly Pro Asn Ala Leu Xaa Pro Pro Pro Xaa Xaa Pro Glu Trp Val 
65                  70                  75                  80  


Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile 
                85                  90                  95      


Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly Xaa Glu 
            100                 105                 110         


Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala 
        115                 120                 125             


Val Val Ile Ile Xaa Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser 
    130                 135                 140                 


Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu 
145                 150                 155                 160 


Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu Val Val 
                165                 170                 175     


Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp 
            180                 185                 190         


Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu 
        195                 200                 205             


Xaa Gly Glu Ser Glu Pro Gln Xaa Arg Ser Pro Asp Cys Xaa His Asp 
    210                 215                 220                 


Asn Pro Leu Glu Xaa Arg Asn Ile Xaa Phe Phe Ser Xaa Asn Cys Val 
225                 230                 235                 240 


Glu Gly Xaa Ala Arg Gly Val Val Val Ala Xaa Gly Asp Arg Xaa Val 
                245                 250                 255     


Met Gly Arg Ile Ala Xaa Leu Ala Ser Gly Leu Glu Val Gly Lys Xaa 
            260                 265                 270         


Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Xaa Gly Val 
        275                 280                 285             


Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly 
    290                 295                 300                 


Tyr Xaa Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala 
305                 310                 315                 320 


Asn Val Pro Glu Gly Leu Leu Ala Xaa Val Xaa Val Cys Leu Xaa Leu 
                325                 330                 335     


Xaa Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu 
            340                 345                 350         


Ala Val Glu Xaa Leu Gly Ser Xaa Ser Xaa Ile Cys Ser Asp Lys Xaa 
        355                 360                 365             


Gly Xaa Leu Xaa Gln Asn Arg Met Xaa Val Ala His Met Trp Phe Asp 
    370                 375                 380                 


Asn Gln Ile His Glu Ala Asp Xaa Xaa Glu Asp Gln Ser Gly Xaa Ser 
385                 390                 395                 400 


Phe Asp Lys Ser Ser His Xaa Trp Val Ala Leu Ser His Ile Ala Gly 
                405                 410                 415     


Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val 
            420                 425                 430         


Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys 
        435                 440                 445             


Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn 
    450                 455                 460                 


Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Xaa Asn Lys Tyr Gln Leu 
465                 470                 475                 480 


Ser Ile His Glu Xaa Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val 
                485                 490                 495     


Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Xaa Ile Leu 
            500                 505                 510         


Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe 
        515                 520                 525             


Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly 
    530                 535                 540                 


Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Phe Pro Lys Gly Phe Ala 
545                 550                 555                 560 


Phe Asp Cys Asp Asp Val Asn Phe Xaa Xaa Asp Asn Leu Cys Phe Val 
                565                 570                 575     


Gly Leu Met Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala 
            580                 585                 590         


Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Xaa Gly 
        595                 600                 605             


Asp His Pro Ile Xaa Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile 
    610                 615                 620                 


Ser Glu Gly Asn Glu Xaa Val Glu Asp Ile Ala Ala Arg Leu Asn Ile 
625                 630                 635                 640 


Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His 
                645                 650                 655     


Gly Xaa Asp Leu Lys Asp Phe Xaa Ser Glu Gln Ile Asp Glu Ile Leu 
            660                 665                 670         


Gln Asn His Xaa Glu Ile Val Phe Ala Arg Xaa Ser Pro Gln Gln Lys 
        675                 680                 685             


Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val 
    690                 695                 700                 


Xaa Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile 
705                 710                 715                 720 


Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala 
                725                 730                 735     


Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Xaa Gly Val 
            740                 745                 750         


Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr 
        755                 760                 765             


Xaa Leu Xaa Ser Asn Ile Pro Glu Ile Xaa Pro Phe Leu Leu Phe Ile 
    770                 775                 780                 


Met Ala Asn Ile Pro Leu Pro Leu Gly Xaa Ile Xaa Ile Leu Cys Ile 
785                 790                 795                 800 


Asp Leu Gly Xaa Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala 
                805                 810                 815     


Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg Xaa Asp 
            820                 825                 830         


Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly 
        835                 840                 845             


Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala 
    850                 855                 860                 


Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp 
865                 870                 875                 880 


Asp Asp Arg Xaa Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
                885                 890                 895     


Xaa Tyr Glu Gln Arg Lys Val Val Glu Phe Xaa Cys His Xaa Ala Phe 
            900                 905                 910         


Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys 
        915                 920                 925             


Xaa Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu 
    930                 935                 940                 


Ile Phe Gly Leu Phe Glu Glu Xaa Ala Leu Ala Ala Phe Leu Ser Tyr 
945                 950                 955                 960 


Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser 
                965                 970                 975     


Trp Trp Phe Cys Ala Phe Pro Tyr Ser Phe Leu Ile Phe Val Tyr Asp 
            980                 985                 990         


Glu Ile Arg Lys Leu Ile Leu Arg  Arg Asn Pro Gly Gly  Trp Val Glu 
        995                 1000                 1005             


Lys Glu  Xaa Tyr Tyr 
    1010             


<210> 3512
<211> 1226
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1196)
<223> Selenocysteine

<400> 3512
Met Gly Asp Lys Lys Asp Asp Lys Asp Ser Pro Lys Lys Asn Lys Gly 
1               5                   10                  15      


Lys Glu Arg Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala Met Xaa 
            20                  25                  30          


Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn Xaa Asp 
        35                  40                  45              


Cys Val Gln Gly Leu Xaa His Ser Lys Ala Gln Glu Ile Leu Ala Arg 
    50                  55                  60                  


Asp Gly Pro Asn Ala Leu Xaa Pro Pro Pro Xaa Xaa Pro Glu Trp Val 
65                  70                  75                  80  


Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile 
                85                  90                  95      


Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly Xaa Glu 
            100                 105                 110         


Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala 
        115                 120                 125             


Val Val Ile Ile Xaa Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser 
    130                 135                 140                 


Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu 
145                 150                 155                 160 


Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu Val Val 
                165                 170                 175     


Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp 
            180                 185                 190         


Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu 
        195                 200                 205             


Xaa Gly Glu Ser Glu Pro Gln Xaa Arg Ser Pro Asp Cys Xaa His Asp 
    210                 215                 220                 


Asn Pro Leu Glu Xaa Arg Asn Ile Xaa Phe Phe Ser Xaa Asn Cys Val 
225                 230                 235                 240 


Glu Gly Xaa Ala Arg Gly Val Val Val Ala Xaa Gly Asp Arg Xaa Val 
                245                 250                 255     


Met Gly Arg Ile Ala Xaa Leu Ala Ser Gly Leu Glu Val Gly Lys Xaa 
            260                 265                 270         


Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Xaa Gly Val 
        275                 280                 285             


Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly 
    290                 295                 300                 


Tyr Xaa Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala 
305                 310                 315                 320 


Asn Val Pro Glu Gly Leu Leu Ala Xaa Val Xaa Val Cys Leu Xaa Leu 
                325                 330                 335     


Xaa Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu 
            340                 345                 350         


Ala Val Glu Xaa Leu Gly Ser Xaa Ser Xaa Ile Cys Ser Asp Lys Xaa 
        355                 360                 365             


Gly Xaa Leu Xaa Gln Asn Arg Met Xaa Val Ala His Met Trp Phe Asp 
    370                 375                 380                 


Asn Gln Ile His Glu Ala Asp Xaa Xaa Glu Asp Gln Ser Gly Xaa Ser 
385                 390                 395                 400 


Phe Asp Lys Ser Ser His Xaa Trp Val Ala Leu Ser His Ile Ala Gly 
                405                 410                 415     


Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val 
            420                 425                 430         


Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys 
        435                 440                 445             


Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn 
    450                 455                 460                 


Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Xaa Asn Lys Tyr Gln Leu 
465                 470                 475                 480 


Ser Ile His Glu Xaa Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val 
                485                 490                 495     


Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Xaa Ile Leu 
            500                 505                 510         


Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe 
        515                 520                 525             


Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly 
    530                 535                 540                 


Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Phe Pro Lys Gly Phe Ala 
545                 550                 555                 560 


Phe Asp Cys Asp Asp Val Asn Phe Xaa Xaa Asp Asn Leu Cys Phe Val 
                565                 570                 575     


Gly Leu Met Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala 
            580                 585                 590         


Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Xaa Gly 
        595                 600                 605             


Asp His Pro Ile Xaa Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile 
    610                 615                 620                 


Ser Glu Gly Asn Glu Xaa Val Glu Asp Ile Ala Ala Arg Leu Asn Ile 
625                 630                 635                 640 


Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His 
                645                 650                 655     


Gly Xaa Asp Leu Lys Asp Phe Xaa Ser Glu Gln Ile Asp Glu Ile Leu 
            660                 665                 670         


Gln Asn His Xaa Glu Ile Val Phe Ala Arg Xaa Ser Pro Gln Gln Lys 
        675                 680                 685             


Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val 
    690                 695                 700                 


Xaa Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile 
705                 710                 715                 720 


Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala 
                725                 730                 735     


Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Xaa Gly Val 
            740                 745                 750         


Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr 
        755                 760                 765             


Xaa Leu Xaa Ser Asn Ile Pro Glu Ile Xaa Pro Phe Leu Leu Phe Ile 
    770                 775                 780                 


Met Ala Asn Ile Pro Leu Pro Leu Gly Xaa Ile Xaa Ile Leu Cys Ile 
785                 790                 795                 800 


Asp Leu Gly Xaa Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala 
                805                 810                 815     


Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg Xaa Asp 
            820                 825                 830         


Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly 
        835                 840                 845             


Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala 
    850                 855                 860                 


Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp 
865                 870                 875                 880 


Asp Asp Arg Xaa Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
                885                 890                 895     


Xaa Tyr Glu Gln Arg Lys Val Val Glu Phe Xaa Cys His Xaa Ala Phe 
            900                 905                 910         


Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys 
        915                 920                 925             


Xaa Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu 
    930                 935                 940                 


Ile Phe Gly Leu Phe Glu Glu Xaa Ala Leu Ala Ala Phe Leu Ser Tyr 
945                 950                 955                 960 


Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser 
                965                 970                 975     


Trp Trp Phe Cys Ala Phe Pro Tyr Ser Phe Leu Ile Phe Val Tyr Asp 
            980                 985                 990         


Glu Ile Arg Lys Leu Ile Leu Arg  Arg Asn Pro Gly Gly  Glu Gly Ala 
        995                 1000                 1005             


Arg Gln  Gly Ser Arg Gly Gly  Arg Gly Ala Ala Gly  Ser Gln Ala 
    1010                 1015                 1020             


Ala Gly  Pro Arg Leu Pro Ser  Pro Cys Trp Met Ala  Leu Pro Pro 
    1025                 1030                 1035             


Gly Ser  His Ser Ser Leu Ser  Ser His Leu Ser Gly  His Pro Leu 
    1040                 1045                 1050             


Cys Leu  Leu Xaa Gly Leu Cys  Leu Cys Gly Phe Leu  Val Ser Leu 
    1055                 1060                 1065             


Pro Leu  Cys Pro Ser Leu Cys  Trp Ala Ala Arg Leu  Ala Cys Leu 
    1070                 1075                 1080             


Ser Pro  Ser Leu Xaa Leu Ser  Leu Ser Phe Leu Leu  Cys Leu Ser 
    1085                 1090                 1095             


Arg Leu  Gly Gly Glu Gly Asn  Leu Leu Leu Xaa Ser  Ala Pro Pro 
    1100                 1105                 1110             


His Arg  Pro Ser Leu Pro Arg  Pro Pro Gly Pro Gly  Pro Pro Leu 
    1115                 1120                 1125             


Ser Val  Pro Pro Ile Leu Tyr  Ser Gly Gly Arg Ser  Pro Leu Phe 
    1130                 1135                 1140             


Leu Trp  Pro His Leu Gly Pro  His Pro Leu His Tyr  Leu Leu Pro 
    1145                 1150                 1155             


Pro Pro  Leu Trp Leu Ala Ser  Leu Pro Cys Pro Lys  Pro Leu Ser 
    1160                 1165                 1170             


Ser Leu  Phe Ser Val Ser Val  Ser Leu Pro Leu Leu  Xaa Pro Leu 
    1175                 1180                 1185             


Ser Ile  Pro Pro Ala Pro Ala  Xaa Ser Leu Gly Ser  Phe Leu Leu 
    1190                 1195                 1200             


Pro Phe  Ser Pro Pro Ala Asp  Ala Ile Ser Gly Ser  Gly Gln Leu 
    1205                 1210                 1215             


Ser Asn  Ile Ser Val Gly Arg  Glu 
    1220                 1225     


<210> 3513
<211> 1024
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<400> 3513
Met Gly Gly Trp Glu Glu Glu Arg Asn Arg Arg Ala Xaa Asp Lys Lys 
1               5                   10                  15      


Asp Asp Lys Asp Ser Pro Lys Lys Asn Lys Gly Lys Glu Arg Arg Asp 
            20                  25                  30          


Leu Asp Asp Leu Lys Lys Glu Val Ala Met Xaa Glu His Lys Met Ser 
        35                  40                  45              


Val Glu Glu Val Cys Arg Lys Tyr Asn Xaa Asp Cys Val Gln Gly Leu 
    50                  55                  60                  


Xaa His Ser Lys Ala Gln Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala 
65                  70                  75                  80  


Leu Xaa Pro Pro Pro Xaa Xaa Pro Glu Trp Val Lys Phe Cys Arg Gln 
                85                  90                  95      


Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile Gly Ala Ile Leu Cys 
            100                 105                 110         


Phe Leu Ala Tyr Gly Ile Gln Ala Gly Xaa Glu Asp Asp Pro Ser Gly 
        115                 120                 125             


Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala Val Val Ile Ile Xaa 
    130                 135                 140                 


Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu 
145                 150                 155                 160 


Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Glu Gly 
                165                 170                 175     


Glu Lys Met Gln Val Asn Ala Glu Glu Val Val Val Gly Asp Leu Val 
            180                 185                 190         


Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp Leu Arg Ile Ile Ser 
        195                 200                 205             


Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu Xaa Gly Glu Ser Glu 
    210                 215                 220                 


Pro Gln Xaa Arg Ser Pro Asp Cys Xaa His Asp Asn Pro Leu Glu Xaa 
225                 230                 235                 240 


Arg Asn Ile Xaa Phe Phe Ser Xaa Asn Cys Val Glu Gly Xaa Ala Arg 
                245                 250                 255     


Gly Val Val Val Ala Xaa Gly Asp Arg Xaa Val Met Gly Arg Ile Ala 
            260                 265                 270         


Xaa Leu Ala Ser Gly Leu Glu Val Gly Lys Xaa Pro Ile Ala Ile Glu 
        275                 280                 285             


Ile Glu His Phe Ile Gln Leu Ile Xaa Gly Val Ala Val Phe Leu Gly 
    290                 295                 300                 


Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly Tyr Xaa Trp Leu Glu 
305                 310                 315                 320 


Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly 
                325                 330                 335     


Leu Leu Ala Xaa Val Xaa Val Cys Leu Xaa Leu Xaa Ala Lys Arg Met 
            340                 345                 350         


Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Xaa Leu 
        355                 360                 365             


Gly Ser Xaa Ser Xaa Ile Cys Ser Asp Lys Xaa Gly Xaa Leu Xaa Gln 
    370                 375                 380                 


Asn Arg Met Xaa Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu 
385                 390                 395                 400 


Ala Asp Xaa Xaa Glu Asp Gln Ser Gly Xaa Ser Phe Asp Lys Ser Ser 
                405                 410                 415     


His Xaa Trp Val Ala Leu Ser His Ile Ala Gly Leu Cys Asn Arg Ala 
            420                 425                 430         


Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val Leu Lys Arg Asp Val 
        435                 440                 445             


Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Ser 
    450                 455                 460                 


Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn Lys Lys Val Ala Glu 
465                 470                 475                 480 


Ile Pro Phe Asn Ser Xaa Asn Lys Tyr Gln Leu Ser Ile His Glu Xaa 
                485                 490                 495     


Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val Met Lys Gly Ala Pro 
            500                 505                 510         


Glu Arg Ile Leu Asp Arg Cys Ser Xaa Ile Leu Leu Gln Gly Lys Glu 
        515                 520                 525             


Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe Gln Asn Ala Tyr Leu 
    530                 535                 540                 


Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Tyr Tyr 
545                 550                 555                 560 


Leu Pro Glu Glu Gln Phe Pro Lys Gly Phe Ala Phe Asp Cys Asp Asp 
                565                 570                 575     


Val Asn Phe Xaa Xaa Asp Asn Leu Cys Phe Val Gly Leu Met Ser Met 
            580                 585                 590         


Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg 
        595                 600                 605             


Ser Ala Gly Ile Lys Val Ile Met Val Xaa Gly Asp His Pro Ile Xaa 
    610                 615                 620                 


Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu 
625                 630                 635                 640 


Xaa Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val 
                645                 650                 655     


Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His Gly Xaa Asp Leu Lys 
            660                 665                 670         


Asp Phe Xaa Ser Glu Gln Ile Asp Glu Ile Leu Gln Asn His Xaa Glu 
        675                 680                 685             


Ile Val Phe Ala Arg Xaa Ser Pro Gln Gln Lys Leu Ile Ile Val Glu 
    690                 695                 700                 


Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val Xaa Gly Asp Gly Val 
705                 710                 715                 720 


Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly 
                725                 730                 735     


Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu 
            740                 745                 750         


Asp Asp Asn Phe Ala Ser Ile Val Xaa Gly Val Glu Glu Gly Arg Leu 
        755                 760                 765             


Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Xaa Leu Xaa Ser Asn 
    770                 775                 780                 


Ile Pro Glu Ile Xaa Pro Phe Leu Leu Phe Ile Met Ala Asn Ile Pro 
785                 790                 795                 800 


Leu Pro Leu Gly Xaa Ile Xaa Ile Leu Cys Ile Asp Leu Gly Xaa Asp 
                805                 810                 815     


Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala Ala Glu Ser Asp Ile 
            820                 825                 830         


Met Lys Arg Gln Pro Arg Asn Pro Arg Xaa Asp Lys Leu Val Asn Glu 
        835                 840                 845             


Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu 
    850                 855                 860                 


Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu 
865                 870                 875                 880 


Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp Asp Asp Arg Xaa Val 
                885                 890                 895     


Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp Xaa Tyr Glu Gln Arg 
            900                 905                 910         


Lys Val Val Glu Phe Xaa Cys His Xaa Ala Phe Phe Val Ser Ile Val 
        915                 920                 925             


Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys Xaa Arg Arg Asn Ser 
    930                 935                 940                 


Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe 
945                 950                 955                 960 


Glu Glu Xaa Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Asp 
                965                 970                 975     


Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser Trp Trp Phe Cys Ala 
            980                 985                 990         


Phe Pro Tyr Ser Phe Leu Ile Phe  Val Tyr Asp Glu Ile  Arg Lys Leu 
        995                 1000                 1005             


Ile Leu  Arg Arg Asn Pro Gly  Gly Trp Val Glu Lys  Glu Xaa Tyr 
    1010                 1015                 1020             


Tyr 
    


<210> 3514
<211> 1026
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<400> 3514
Met Gly Ser Gly Gly Ser Asp Ser Tyr Arg Ile Ala Xaa Ser Gln Asp 
1               5                   10                  15      


Lys Lys Asp Asp Lys Asp Ser Pro Lys Lys Asn Lys Gly Lys Glu Arg 
            20                  25                  30          


Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala Met Xaa Glu His Lys 
        35                  40                  45              


Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn Xaa Asp Cys Val Gln 
    50                  55                  60                  


Gly Leu Xaa His Ser Lys Ala Gln Glu Ile Leu Ala Arg Asp Gly Pro 
65                  70                  75                  80  


Asn Ala Leu Xaa Pro Pro Pro Xaa Xaa Pro Glu Trp Val Lys Phe Cys 
                85                  90                  95      


Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile Gly Ala Ile 
            100                 105                 110         


Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly Xaa Glu Asp Asp Pro 
        115                 120                 125             


Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala Val Val Ile 
    130                 135                 140                 


Ile Xaa Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile 
145                 150                 155                 160 


Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg 
                165                 170                 175     


Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu Val Val Val Gly Asp 
            180                 185                 190         


Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp Leu Arg Ile 
        195                 200                 205             


Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu Xaa Gly Glu 
    210                 215                 220                 


Ser Glu Pro Gln Xaa Arg Ser Pro Asp Cys Xaa His Asp Asn Pro Leu 
225                 230                 235                 240 


Glu Xaa Arg Asn Ile Xaa Phe Phe Ser Xaa Asn Cys Val Glu Gly Xaa 
                245                 250                 255     


Ala Arg Gly Val Val Val Ala Xaa Gly Asp Arg Xaa Val Met Gly Arg 
            260                 265                 270         


Ile Ala Xaa Leu Ala Ser Gly Leu Glu Val Gly Lys Xaa Pro Ile Ala 
        275                 280                 285             


Ile Glu Ile Glu His Phe Ile Gln Leu Ile Xaa Gly Val Ala Val Phe 
    290                 295                 300                 


Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly Tyr Xaa Trp 
305                 310                 315                 320 


Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro 
                325                 330                 335     


Glu Gly Leu Leu Ala Xaa Val Xaa Val Cys Leu Xaa Leu Xaa Ala Lys 
            340                 345                 350         


Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu 
        355                 360                 365             


Xaa Leu Gly Ser Xaa Ser Xaa Ile Cys Ser Asp Lys Xaa Gly Xaa Leu 
    370                 375                 380                 


Xaa Gln Asn Arg Met Xaa Val Ala His Met Trp Phe Asp Asn Gln Ile 
385                 390                 395                 400 


His Glu Ala Asp Xaa Xaa Glu Asp Gln Ser Gly Xaa Ser Phe Asp Lys 
                405                 410                 415     


Ser Ser His Xaa Trp Val Ala Leu Ser His Ile Ala Gly Leu Cys Asn 
            420                 425                 430         


Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val Leu Lys Arg 
        435                 440                 445             


Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu 
    450                 455                 460                 


Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn Lys Lys Val 
465                 470                 475                 480 


Ala Glu Ile Pro Phe Asn Ser Xaa Asn Lys Tyr Gln Leu Ser Ile His 
                485                 490                 495     


Glu Xaa Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val Met Lys Gly 
            500                 505                 510         


Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Xaa Ile Leu Leu Gln Gly 
        515                 520                 525             


Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe Gln Asn Ala 
    530                 535                 540                 


Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His 
545                 550                 555                 560 


Tyr Tyr Leu Pro Glu Glu Gln Phe Pro Lys Gly Phe Ala Phe Asp Cys 
                565                 570                 575     


Asp Asp Val Asn Phe Xaa Xaa Asp Asn Leu Cys Phe Val Gly Leu Met 
            580                 585                 590         


Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys 
        595                 600                 605             


Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Xaa Gly Asp His Pro 
    610                 615                 620                 


Ile Xaa Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly 
625                 630                 635                 640 


Asn Glu Xaa Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser 
                645                 650                 655     


Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His Gly Xaa Asp 
            660                 665                 670         


Leu Lys Asp Phe Xaa Ser Glu Gln Ile Asp Glu Ile Leu Gln Asn His 
        675                 680                 685             


Xaa Glu Ile Val Phe Ala Arg Xaa Ser Pro Gln Gln Lys Leu Ile Ile 
    690                 695                 700                 


Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val Xaa Gly Asp 
705                 710                 715                 720 


Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala 
                725                 730                 735     


Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile 
            740                 745                 750         


Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Xaa Gly Val Glu Glu Gly 
        755                 760                 765             


Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Xaa Leu Xaa 
    770                 775                 780                 


Ser Asn Ile Pro Glu Ile Xaa Pro Phe Leu Leu Phe Ile Met Ala Asn 
785                 790                 795                 800 


Ile Pro Leu Pro Leu Gly Xaa Ile Xaa Ile Leu Cys Ile Asp Leu Gly 
                805                 810                 815     


Xaa Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala Ala Glu Ser 
            820                 825                 830         


Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg Xaa Asp Lys Leu Val 
        835                 840                 845             


Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln 
    850                 855                 860                 


Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala Glu Asn Gly 
865                 870                 875                 880 


Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp Asp Asp Arg 
                885                 890                 895     


Xaa Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp Xaa Tyr Glu 
            900                 905                 910         


Gln Arg Lys Val Val Glu Phe Xaa Cys His Xaa Ala Phe Phe Val Ser 
        915                 920                 925             


Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys Xaa Arg Arg 
    930                 935                 940                 


Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly 
945                 950                 955                 960 


Leu Phe Glu Glu Xaa Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly 
                965                 970                 975     


Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser Trp Trp Phe 
            980                 985                 990         


Cys Ala Phe Pro Tyr Ser Phe Leu  Ile Phe Val Tyr Asp  Glu Ile Arg 
        995                 1000                 1005             


Lys Leu  Ile Leu Arg Arg Asn  Pro Gly Gly Trp Val  Glu Lys Glu 
    1010                 1015                 1020             


Xaa Tyr  Tyr 
    1025     


<210> 3515
<211> 251
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<400> 3515
Met Xaa Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn 
1               5                   10                  15      


Xaa Asp Cys Val Gln Gly Leu Xaa His Ser Lys Ala Gln Glu Ile Leu 
            20                  25                  30          


Ala Arg Asp Gly Pro Asn Ala Leu Xaa Pro Pro Pro Xaa Xaa Pro Glu 
        35                  40                  45              


Trp Val Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu 
    50                  55                  60                  


Trp Ile Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly 
65                  70                  75                  80  


Xaa Glu Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu 
                85                  90                  95      


Ala Ala Val Val Ile Ile Xaa Gly Cys Phe Ser Tyr Tyr Gln Glu Ala 
            100                 105                 110         


Lys Ser Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln 
        115                 120                 125             


Ala Leu Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu 
    130                 135                 140                 


Val Val Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro 
145                 150                 155                 160 


Ala Asp Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser 
                165                 170                 175     


Ser Leu Xaa Gly Glu Ser Glu Pro Gln Xaa Arg Ser Pro Asp Cys Xaa 
            180                 185                 190         


His Asp Asn Pro Leu Glu Xaa Arg Asn Ile Xaa Phe Phe Ser Xaa Asn 
        195                 200                 205             


Cys Val Glu Gly Xaa Ala Arg Gly Val Val Val Ala Xaa Gly Asp Arg 
    210                 215                 220                 


Xaa Val Met Gly Arg Ile Ala Xaa Leu Ala Ser Gly Leu Glu Val Gly 
225                 230                 235                 240 


Lys Xaa Pro Ile Ala Ile Glu Ile Glu His Phe 
                245                 250     


<210> 3516
<211> 983
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<400> 3516
Met Xaa Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn 
1               5                   10                  15      


Xaa Asp Cys Val Gln Gly Leu Xaa His Ser Lys Ala Gln Glu Ile Leu 
            20                  25                  30          


Ala Arg Asp Gly Pro Asn Ala Leu Xaa Pro Pro Pro Xaa Xaa Pro Glu 
        35                  40                  45              


Trp Val Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu 
    50                  55                  60                  


Trp Ile Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly 
65                  70                  75                  80  


Xaa Glu Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu 
                85                  90                  95      


Ala Ala Val Val Ile Ile Xaa Gly Cys Phe Ser Tyr Tyr Gln Glu Ala 
            100                 105                 110         


Lys Ser Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln 
        115                 120                 125             


Ala Leu Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu 
    130                 135                 140                 


Val Val Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro 
145                 150                 155                 160 


Ala Asp Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser 
                165                 170                 175     


Ser Leu Xaa Gly Glu Ser Glu Pro Gln Xaa Arg Ser Pro Asp Cys Xaa 
            180                 185                 190         


His Asp Asn Pro Leu Glu Xaa Arg Asn Ile Xaa Phe Phe Ser Xaa Asn 
        195                 200                 205             


Cys Val Glu Gly Xaa Ala Arg Gly Val Val Val Ala Xaa Gly Asp Arg 
    210                 215                 220                 


Xaa Val Met Gly Arg Ile Ala Xaa Leu Ala Ser Gly Leu Glu Val Gly 
225                 230                 235                 240 


Lys Xaa Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Xaa 
                245                 250                 255     


Gly Val Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile 
            260                 265                 270         


Leu Gly Tyr Xaa Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile 
        275                 280                 285             


Val Ala Asn Val Pro Glu Gly Leu Leu Ala Xaa Val Xaa Val Cys Leu 
    290                 295                 300                 


Xaa Leu Xaa Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn 
305                 310                 315                 320 


Leu Glu Ala Val Glu Xaa Leu Gly Ser Xaa Ser Xaa Ile Cys Ser Asp 
                325                 330                 335     


Lys Xaa Gly Xaa Leu Xaa Gln Asn Arg Met Xaa Val Ala His Met Trp 
            340                 345                 350         


Phe Asp Asn Gln Ile His Glu Ala Asp Xaa Xaa Glu Asp Gln Ser Gly 
        355                 360                 365             


Xaa Ser Phe Asp Lys Ser Ser His Xaa Trp Val Ala Leu Ser His Ile 
    370                 375                 380                 


Ala Gly Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile 
385                 390                 395                 400 


Pro Val Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu 
                405                 410                 415     


Leu Lys Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu 
            420                 425                 430         


Arg Asn Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Xaa Asn Lys Tyr 
        435                 440                 445             


Gln Leu Ser Ile His Glu Xaa Glu Asp Pro Asn Asp Asn Arg Tyr Leu 
    450                 455                 460                 


Leu Val Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Xaa 
465                 470                 475                 480 


Ile Leu Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu 
                485                 490                 495     


Ala Phe Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val 
            500                 505                 510         


Leu Gly Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Phe Pro Lys Gly 
        515                 520                 525             


Phe Ala Phe Asp Cys Asp Asp Val Asn Phe Xaa Xaa Asp Asn Leu Cys 
    530                 535                 540                 


Phe Val Gly Leu Met Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro 
545                 550                 555                 560 


Asp Ala Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val 
                565                 570                 575     


Xaa Gly Asp His Pro Ile Xaa Ala Lys Ala Ile Ala Lys Gly Val Gly 
            580                 585                 590         


Ile Ile Ser Glu Gly Asn Glu Xaa Val Glu Asp Ile Ala Ala Arg Leu 
        595                 600                 605             


Asn Ile Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val 
    610                 615                 620                 


Ile His Gly Xaa Asp Leu Lys Asp Phe Xaa Ser Glu Gln Ile Asp Glu 
625                 630                 635                 640 


Ile Leu Gln Asn His Xaa Glu Ile Val Phe Ala Arg Xaa Ser Pro Gln 
                645                 650                 655     


Gln Lys Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val 
            660                 665                 670         


Ala Val Xaa Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala 
        675                 680                 685             


Asp Ile Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln 
    690                 695                 700                 


Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Xaa 
705                 710                 715                 720 


Gly Val Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile 
                725                 730                 735     


Ala Tyr Xaa Leu Xaa Ser Asn Ile Pro Glu Ile Xaa Pro Phe Leu Leu 
            740                 745                 750         


Phe Ile Met Ala Asn Ile Pro Leu Pro Leu Gly Xaa Ile Xaa Ile Leu 
        755                 760                 765             


Cys Ile Asp Leu Gly Xaa Asp Met Val Pro Ala Ile Ser Leu Ala Tyr 
    770                 775                 780                 


Glu Ala Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg 
785                 790                 795                 800 


Xaa Asp Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln 
                805                 810                 815     


Ile Gly Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile 
            820                 825                 830         


Leu Ala Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu 
        835                 840                 845             


Asn Trp Asp Asp Arg Xaa Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln 
    850                 855                 860                 


Gln Trp Xaa Tyr Glu Gln Arg Lys Val Val Glu Phe Xaa Cys His Xaa 
865                 870                 875                 880 


Ala Phe Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile 
                885                 890                 895     


Cys Lys Xaa Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys 
            900                 905                 910         


Ile Leu Ile Phe Gly Leu Phe Glu Glu Xaa Ala Leu Ala Ala Phe Leu 
        915                 920                 925             


Ser Tyr Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys 
    930                 935                 940                 


Pro Ser Trp Trp Phe Cys Ala Phe Pro Tyr Ser Phe Leu Ile Phe Val 
945                 950                 955                 960 


Tyr Asp Glu Ile Arg Lys Leu Ile Leu Arg Arg Asn Pro Gly Gly Trp 
                965                 970                 975     


Val Glu Lys Glu Xaa Tyr Tyr 
            980             


<210> 3517
<211> 303
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<400> 3517
Met Ala Arg Gly Lys Ala Lys Glu Glu Gly Ser Trp Lys Lys Phe Ile 
1               5                   10                  15      


Trp Asn Ser Glu Lys Lys Glu Phe Leu Gly Arg Xaa Gly Gly Ser Trp 
            20                  25                  30          


Phe Lys Ile Leu Leu Phe Tyr Val Ile Phe Tyr Gly Cys Leu Ala Gly 
        35                  40                  45              


Ile Phe Ile Gly Xaa Ile Gln Val Met Leu Leu Xaa Ile Ser Glu Phe 
    50                  55                  60                  


Lys Pro Xaa Tyr Gln Asp Arg Val Ala Pro Pro Gly Leu Xaa Gln Ile 
65                  70                  75                  80  


Pro Gln Ile Gln Lys Xaa Glu Ile Ser Phe Arg Pro Asn Asp Pro Lys 
                85                  90                  95      


Ser Tyr Glu Ala Tyr Val Leu Asn Ile Val Arg Phe Leu Glu Lys Tyr 
            100                 105                 110         


Lys Asp Ser Ala Gln Arg Asp Asp Met Ile Phe Glu Asp Cys Gly Asp 
        115                 120                 125             


Val Pro Ser Glu Pro Lys Glu Arg Gly Asp Phe Asn His Glu Arg Gly 
    130                 135                 140                 


Glu Arg Lys Val Cys Arg Phe Lys Leu Glu Trp Leu Gly Asn Cys Ser 
145                 150                 155                 160 


Gly Leu Asn Asp Glu Xaa Tyr Gly Tyr Lys Glu Gly Lys Pro Cys Ile 
                165                 170                 175     


Ile Ile Lys Leu Asn Arg Val Leu Gly Phe Lys Pro Lys Pro Pro Lys 
            180                 185                 190         


Asn Glu Ser Leu Glu Xaa Tyr Pro Val Met Lys Tyr Asn Pro Asn Val 
        195                 200                 205             


Leu Pro Val Gln Cys Xaa Gly Lys Arg Asp Glu Asp Lys Asp Lys Val 
    210                 215                 220                 


Gly Asn Val Glu Tyr Phe Gly Leu Gly Asn Ser Pro Gly Phe Pro Leu 
225                 230                 235                 240 


Gln Tyr Tyr Pro Tyr Tyr Gly Lys Leu Leu Gln Pro Lys Tyr Leu Gln 
                245                 250                 255     


Pro Leu Leu Ala Val Gln Phe Xaa Asn Leu Xaa Met Asp Xaa Glu Ile 
            260                 265                 270         


Arg Ile Glu Cys Lys Ala Tyr Gly Glu Asn Ile Gly Tyr Ser Glu Lys 
        275                 280                 285             


Asp Arg Phe Gln Gly Arg Phe Asp Val Lys Ile Glu Val Lys Ser 
    290                 295                 300             


<210> 3518
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 3518
Met Leu Leu Xaa Ile Ser Glu Phe Lys Pro Xaa Tyr Gln Asp Arg Val 
1               5                   10                  15      


Ala Pro Pro Gly Leu Xaa Gln Ile Pro Gln Ile Gln Lys Xaa Glu Ile 
            20                  25                  30          


Ser Phe Arg Pro Asn Asp Pro Lys Ser Tyr Glu Ala Tyr Val Leu Asn 
        35                  40                  45              


Ile Val Arg Phe Leu Glu Lys Tyr Lys Asp Ser Ala Gln Arg Asp Asp 
    50                  55                  60                  


Met Ile Phe Glu Asp Cys Gly Asp Val Pro Ser Glu Pro Lys Glu Arg 
65                  70                  75                  80  


Gly Asp Phe Asn His Glu Arg Gly Glu Arg Lys Val Cys Arg Phe Lys 
                85                  90                  95      


Leu Glu Trp Leu Gly Asn Cys Ser Gly Leu Asn Asp Glu Xaa Tyr Gly 
            100                 105                 110         


Tyr Lys Glu Gly Lys Pro Cys Ile Ile Ile Lys Leu Asn Arg Val Leu 
        115                 120                 125             


Gly Phe 
    130 


<210> 3519
<211> 994
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<400> 3519
Met Glu Ala Ala His Ala Lys Xaa Xaa Glu Glu Cys Leu Ala Tyr Phe 
1               5                   10                  15      


Gly Val Ser Glu Xaa Xaa Gly Leu Xaa Pro Asp Gln Val Lys Arg Asn 
            20                  25                  30          


Leu Glu Lys Tyr Gly Leu Asn Glu Leu Pro Ala Glu Glu Gly Lys Xaa 
        35                  40                  45              


Leu Trp Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Xaa Ile Xaa Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Ile Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Ala Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Ile Leu Ala Ile Lys Ser Xaa Xaa Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Xaa Gly Glu Ser Val Ser Val Ile Lys His Xaa Glu 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Xaa Asn Ile Ala Ala Gly Lys Ala Leu Gly Ile Val Ala 
    210                 215                 220                 


Xaa Xaa Gly Val Gly Xaa Glu Ile Gly Lys Ile Arg Asp Gln Met Ala 
225                 230                 235                 240 


Ala Xaa Glu Gln Asp Lys Xaa Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Val Ala Val Trp 
            260                 265                 270         


Leu Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Phe Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Xaa Xaa Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Xaa Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Xaa Leu Gly Cys Xaa Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Xaa Gly Xaa Leu Xaa Xaa Asn Gln Met Ser Val Cys Lys Met Phe Ile 
        355                 360                 365             


Ile Asp Lys Val Asp Gly Asp Ile Cys Leu Leu Asn Glu Phe Ser Ile 
    370                 375                 380                 


Xaa Gly Ser Xaa Tyr Ala Pro Glu Gly Glu Val Leu Lys Asn Asp Lys 
385                 390                 395                 400 


Pro Val Arg Pro Gly Gln Tyr Asp Gly Leu Val Glu Leu Ala Xaa Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ser Leu Asp Phe Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Xaa Glu Xaa Ala Leu Xaa Xaa Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asn Xaa Asp Val Arg Ser Leu Ser Lys 
    450                 455                 460                 


Val Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Arg Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Xaa Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Ser Pro Ala Lys Ser Ser Arg Ala Ala Val Gly Asn Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Asn Tyr Val 
        515                 520                 525             


Arg Val Gly Xaa Xaa Arg Val Pro Leu Xaa Gly Pro Val Lys Glu Lys 
    530                 535                 540                 


Ile Met Ala Val Ile Lys Glu Trp Gly Xaa Gly Arg Asp Xaa Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Xaa Arg Asp Xaa Pro Pro Lys Arg Glu Glu Met 
                565                 570                 575     


Val Leu Asp Asp Ser Ala Arg Phe Leu Glu Tyr Glu Xaa Asp Leu Xaa 
            580                 585                 590         


Phe Val Gly Val Val Gly Met Leu Asp Pro Pro Arg Lys Glu Val Xaa 
        595                 600                 605             


Gly Ser Ile Gln Leu Cys Arg Asp Ala Gly Ile Arg Val Ile Met Ile 
    610                 615                 620                 


Xaa Gly Asp Asn Lys Gly Xaa Ala Ile Ala Ile Cys Arg Arg Ile Gly 
625                 630                 635                 640 


Ile Phe Gly Glu Asn Glu Glu Val Ala Asp Arg Ala Tyr Xaa Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Pro Leu Ala Glu Gln Arg Glu Ala Cys Arg Arg 
            660                 665                 670         


Ala Cys Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val 
        675                 680                 685             


Glu Tyr Leu Gln Ser Tyr Asp Glu Ile Xaa Ala Met Xaa Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Xaa Ala Val Ala Lys Xaa Ala Ser Glu Met Val Leu Ala 
                725                 730                 735     


Asp Asp Asn Phe Ser Xaa Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Xaa Ala Ala Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Xaa Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Xaa Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Asp Arg Pro Pro Arg Ser Pro Lys Glu Pro Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Met Ala Ile Gly Gly Tyr Val Gly Ala Ala Xaa 
        835                 840                 845             


Val Gly Ala Ala Ala Trp Trp Phe Leu Tyr Ala Glu Asp Gly Pro His 
    850                 855                 860                 


Val Asn Tyr Ser Gln Leu Xaa His Phe Met Gln Cys Xaa Glu Asp Asn 
865                 870                 875                 880 


Xaa His Phe Glu Gly Ile Asp Cys Glu Val Phe Glu Ala Pro Glu Pro 
                885                 890                 895     


Met Xaa Met Ala Leu Ser Val Leu Val Xaa Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Val Asn Ile Trp Leu Leu Gly Ser Ile Cys Leu Ser Met Ser Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Tyr Val Asp Pro Leu Pro Met Ile Phe Lys Leu Arg 
945                 950                 955                 960 


Ala Leu Asp Leu Xaa Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Gly Leu Asp Glu Ile Leu Lys Phe Val Ala Arg Asn Tyr Leu 
            980                 985                 990         


Glu Gly 
        


<210> 3520
<211> 1001
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<400> 3520
Met Glu Ala Ala His Ala Lys Xaa Xaa Glu Glu Cys Leu Ala Tyr Phe 
1               5                   10                  15      


Gly Val Ser Glu Xaa Xaa Gly Leu Xaa Pro Asp Gln Val Lys Arg Asn 
            20                  25                  30          


Leu Glu Lys Tyr Gly Leu Asn Glu Leu Pro Ala Glu Glu Gly Lys Xaa 
        35                  40                  45              


Leu Trp Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Xaa Ile Xaa Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Ile Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Ala Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Ile Leu Ala Ile Lys Ser Xaa Xaa Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Xaa Gly Glu Ser Val Ser Val Ile Lys His Xaa Glu 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Xaa Asn Ile Ala Ala Gly Lys Ala Leu Gly Ile Val Ala 
    210                 215                 220                 


Xaa Xaa Gly Val Gly Xaa Glu Ile Gly Lys Ile Arg Asp Gln Met Ala 
225                 230                 235                 240 


Ala Xaa Glu Gln Asp Lys Xaa Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Val Ala Val Trp 
            260                 265                 270         


Leu Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Phe Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Xaa Xaa Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Xaa Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Xaa Leu Gly Cys Xaa Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Xaa Gly Xaa Leu Xaa Xaa Asn Gln Met Ser Val Cys Lys Met Phe Ile 
        355                 360                 365             


Ile Asp Lys Val Asp Gly Asp Ile Cys Leu Leu Asn Glu Phe Ser Ile 
    370                 375                 380                 


Xaa Gly Ser Xaa Tyr Ala Pro Glu Gly Glu Val Leu Lys Asn Asp Lys 
385                 390                 395                 400 


Pro Val Arg Pro Gly Gln Tyr Asp Gly Leu Val Glu Leu Ala Xaa Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ser Leu Asp Phe Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Xaa Glu Xaa Ala Leu Xaa Xaa Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asn Xaa Asp Val Arg Ser Leu Ser Lys 
    450                 455                 460                 


Val Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Arg Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Xaa Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Ser Pro Ala Lys Ser Ser Arg Ala Ala Val Gly Asn Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Asn Tyr Val 
        515                 520                 525             


Arg Val Gly Xaa Xaa Arg Val Pro Leu Xaa Gly Pro Val Lys Glu Lys 
    530                 535                 540                 


Ile Met Ala Val Ile Lys Glu Trp Gly Xaa Gly Arg Asp Xaa Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Xaa Arg Asp Xaa Pro Pro Lys Arg Glu Glu Met 
                565                 570                 575     


Val Leu Asp Asp Ser Ala Arg Phe Leu Glu Tyr Glu Xaa Asp Leu Xaa 
            580                 585                 590         


Phe Val Gly Val Val Gly Met Leu Asp Pro Pro Arg Lys Glu Val Xaa 
        595                 600                 605             


Gly Ser Ile Gln Leu Cys Arg Asp Ala Gly Ile Arg Val Ile Met Ile 
    610                 615                 620                 


Xaa Gly Asp Asn Lys Gly Xaa Ala Ile Ala Ile Cys Arg Arg Ile Gly 
625                 630                 635                 640 


Ile Phe Gly Glu Asn Glu Glu Val Ala Asp Arg Ala Tyr Xaa Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Pro Leu Ala Glu Gln Arg Glu Ala Cys Arg Arg 
            660                 665                 670         


Ala Cys Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val 
        675                 680                 685             


Glu Tyr Leu Gln Ser Tyr Asp Glu Ile Xaa Ala Met Xaa Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Xaa Ala Val Ala Lys Xaa Ala Ser Glu Met Val Leu Ala 
                725                 730                 735     


Asp Asp Asn Phe Ser Xaa Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Xaa Ala Ala Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Xaa Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Xaa Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Asp Arg Pro Pro Arg Ser Pro Lys Glu Pro Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Met Ala Ile Gly Gly Tyr Val Gly Ala Ala Xaa 
        835                 840                 845             


Val Gly Ala Ala Ala Trp Trp Phe Leu Tyr Ala Glu Asp Gly Pro His 
    850                 855                 860                 


Val Asn Tyr Ser Gln Leu Xaa His Phe Met Gln Cys Xaa Glu Asp Asn 
865                 870                 875                 880 


Xaa His Phe Glu Gly Ile Asp Cys Glu Val Phe Glu Ala Pro Glu Pro 
                885                 890                 895     


Met Xaa Met Ala Leu Ser Val Leu Val Xaa Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Val Asn Ile Trp Leu Leu Gly Ser Ile Cys Leu Ser Met Ser Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Tyr Val Asp Pro Leu Pro Met Ile Phe Lys Leu Arg 
945                 950                 955                 960 


Ala Leu Asp Leu Xaa Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Gly Leu Asp Glu Ile Leu Lys Phe Val Ala Arg Asn Tyr Leu 
            980                 985                 990         


Glu Asp Pro Glu Asp Glu Arg Arg  Lys 
        995                 1000     


<210> 3521
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3521
Met Gly Lys Val Tyr Arg Ala Asp Arg Lys Ser Val Gln Arg Ile Lys 
1               5                   10                  15      


Ala Arg Asp Ile Val Pro Gly Asp Ile Val 
            20                  25      


<210> 3522
<211> 869
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<400> 3522
Met Gly Lys Val Tyr Arg Ala Asp Arg Lys Ser Val Gln Arg Ile Lys 
1               5                   10                  15      


Ala Arg Asp Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp 
            20                  25                  30          


Lys Val Pro Ala Asp Ile Arg Ile Leu Ala Ile Lys Ser Xaa Xaa Leu 
        35                  40                  45              


Arg Val Asp Gln Ser Ile Leu Xaa Gly Glu Ser Val Ser Val Ile Lys 
    50                  55                  60                  


His Xaa Glu Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys 
65                  70                  75                  80  


Asn Met Leu Phe Ser Gly Xaa Asn Ile Ala Ala Gly Lys Ala Leu Gly 
                85                  90                  95      


Ile Val Ala Xaa Xaa Gly Val Gly Xaa Glu Ile Gly Lys Ile Arg Asp 
            100                 105                 110         


Gln Met Ala Ala Xaa Glu Gln Asp Lys Xaa Pro Leu Gln Gln Lys Leu 
        115                 120                 125             


Asp Glu Phe Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Val 
    130                 135                 140                 


Ala Val Trp Leu Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly 
145                 150                 155                 160 


Gly Ser Trp Phe Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala 
                165                 170                 175     


Leu Ala Val Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Xaa Xaa 
            180                 185                 190         


Cys Leu Ala Leu Gly Xaa Arg Arg Met Ala Lys Lys Asn Ala Ile Val 
        195                 200                 205             


Arg Ser Leu Pro Ser Val Glu Xaa Leu Gly Cys Xaa Ser Val Ile Cys 
    210                 215                 220                 


Ser Asp Lys Xaa Gly Xaa Leu Xaa Xaa Asn Gln Met Ser Val Cys Lys 
225                 230                 235                 240 


Met Phe Ile Ile Asp Lys Val Asp Gly Asp Ile Cys Leu Leu Asn Glu 
                245                 250                 255     


Phe Ser Ile Xaa Gly Ser Xaa Tyr Ala Pro Glu Gly Glu Val Leu Lys 
            260                 265                 270         


Asn Asp Lys Pro Val Arg Pro Gly Gln Tyr Asp Gly Leu Val Glu Leu 
        275                 280                 285             


Ala Xaa Ile Cys Ala Leu Cys Asn Asp Ser Ser Leu Asp Phe Asn Glu 
    290                 295                 300                 


Ala Lys Gly Val Tyr Glu Lys Val Gly Glu Ala Xaa Glu Xaa Ala Leu 
305                 310                 315                 320 


Xaa Xaa Leu Val Glu Lys Met Asn Val Phe Asn Xaa Asp Val Arg Ser 
                325                 330                 335     


Leu Ser Lys Val Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Arg Gln 
            340                 345                 350         


Leu Met Lys Lys Glu Phe Xaa Leu Glu Phe Ser Arg Asp Arg Lys Ser 
        355                 360                 365             


Met Ser Val Tyr Cys Ser Pro Ala Lys Ser Ser Arg Ala Ala Val Gly 
    370                 375                 380                 


Asn Lys Met Phe Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys 
385                 390                 395                 400 


Asn Tyr Val Arg Val Gly Xaa Xaa Arg Val Pro Leu Xaa Gly Pro Val 
                405                 410                 415     


Lys Glu Lys Ile Met Ala Val Ile Lys Glu Trp Gly Xaa Gly Arg Asp 
            420                 425                 430         


Xaa Leu Arg Cys Leu Ala Leu Ala Xaa Arg Asp Xaa Pro Pro Lys Arg 
        435                 440                 445             


Glu Glu Met Val Leu Asp Asp Ser Ala Arg Phe Leu Glu Tyr Glu Xaa 
    450                 455                 460                 


Asp Leu Xaa Phe Val Gly Val Val Gly Met Leu Asp Pro Pro Arg Lys 
465                 470                 475                 480 


Glu Val Xaa Gly Ser Ile Gln Leu Cys Arg Asp Ala Gly Ile Arg Val 
                485                 490                 495     


Ile Met Ile Xaa Gly Asp Asn Lys Gly Xaa Ala Ile Ala Ile Cys Arg 
            500                 505                 510         


Arg Ile Gly Ile Phe Gly Glu Asn Glu Glu Val Ala Asp Arg Ala Tyr 
        515                 520                 525             


Xaa Gly Arg Glu Phe Asp Asp Leu Pro Leu Ala Glu Gln Arg Glu Ala 
    530                 535                 540                 


Cys Arg Arg Ala Cys Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser 
545                 550                 555                 560 


Lys Ile Val Glu Tyr Leu Gln Ser Tyr Asp Glu Ile Xaa Ala Met Xaa 
                565                 570                 575     


Gly Asp Gly Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly 
            580                 585                 590         


Ile Ala Met Gly Ser Gly Xaa Ala Val Ala Lys Xaa Ala Ser Glu Met 
        595                 600                 605             


Val Leu Ala Asp Asp Asn Phe Ser Xaa Ile Val Ala Ala Val Glu Glu 
    610                 615                 620                 


Gly Arg Ala Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile 
625                 630                 635                 640 


Ser Ser Asn Val Gly Glu Val Val Cys Ile Phe Leu Xaa Ala Ala Leu 
                645                 650                 655     


Gly Leu Pro Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu 
            660                 665                 670         


Val Xaa Asp Gly Leu Pro Ala Xaa Ala Leu Gly Phe Asn Pro Pro Asp 
        675                 680                 685             


Leu Asp Ile Met Asp Arg Pro Pro Arg Ser Pro Lys Glu Pro Leu Ile 
    690                 695                 700                 


Ser Gly Trp Leu Phe Phe Arg Tyr Met Ala Ile Gly Gly Tyr Val Gly 
705                 710                 715                 720 


Ala Ala Xaa Val Gly Ala Ala Ala Trp Trp Phe Leu Tyr Ala Glu Asp 
                725                 730                 735     


Gly Pro His Val Asn Tyr Ser Gln Leu Xaa His Phe Met Gln Cys Xaa 
            740                 745                 750         


Glu Asp Asn Xaa His Phe Glu Gly Ile Asp Cys Glu Val Phe Glu Ala 
        755                 760                 765             


Pro Glu Pro Met Xaa Met Ala Leu Ser Val Leu Val Xaa Ile Glu Met 
    770                 775                 780                 


Cys Asn Ala Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met 
785                 790                 795                 800 


Pro Pro Trp Val Asn Ile Trp Leu Leu Gly Ser Ile Cys Leu Ser Met 
                805                 810                 815     


Ser Leu His Phe Leu Ile Leu Tyr Val Asp Pro Leu Pro Met Ile Phe 
            820                 825                 830         


Lys Leu Arg Ala Leu Asp Leu Xaa Gln Trp Leu Met Val Leu Lys Ile 
        835                 840                 845             


Ser Leu Pro Val Ile Gly Leu Asp Glu Ile Leu Lys Phe Val Ala Arg 
    850                 855                 860                 


Asn Tyr Leu Glu Gly 
865                 


<210> 3523
<211> 114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<400> 3523
Met Asn Leu Ser Phe Ser Ser Phe Ser Trp Val Glu Leu Pro Ala Glu 
1               5                   10                  15      


Glu Gly Lys Xaa Leu Trp Glu Leu Val Ile Glu Gln Phe Glu Asp Leu 
            20                  25                  30          


Leu Val Arg Ile Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala 
        35                  40                  45              


Trp Phe Glu Glu Gly Glu Glu Xaa Ile Xaa Ala Phe Val Glu Pro Phe 
    50                  55                  60                  


Val Ile Leu Leu Ile Leu Ile Ala Asn Ala Ile Val Gly Val Trp Gln 
65                  70                  75                  80  


Glu Arg Asn Ala Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro 
                85                  90                  95      


Glu Met Gly Lys Val Tyr Arg Ala Asp Arg Lys Ser Val Gln Arg Ile 
            100                 105                 110         


Lys Ala 
        


<210> 3524
<211> 41
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<400> 3524
Val Ile Cys Ser Asp Lys Xaa Gly Xaa Leu Xaa Xaa Asn Gln Met Ser 
1               5                   10                  15      


Val Cys Lys Gly Leu Pro Leu Xaa Ser Gly Gln Glu Pro Leu Pro Phe 
            20                  25                  30          


Xaa Glu Phe Cys Gly Arg Leu His Pro 
        35                  40      


<210> 3525
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<400> 3525
Xaa Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val Ala 
1               5                   10                  15      


Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Xaa Xaa Cys Leu Ala Leu 
            20                  25                  30          


Gly Xaa Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu Pro 
        35                  40                  45              


Ser Val Glu Xaa Leu Gly Cys Xaa Ser Val Ile Cys Ser Asp Lys Xaa 
    50                  55                  60                  


Gly Xaa Leu Xaa Xaa Asn Gln Met Ser Val Cys Lys Met Phe Ile Ile 
65                  70                  75                  80  


Asp Lys Val Asp Gly Asp Ile Cys Leu Leu Asn Glu Phe Ser Ile Xaa 
                85                  90                  95      


Gly Ser Xaa Tyr Ala Pro Glu Gly Glu Val Pro Lys Val Ser Met Arg 
            100                 105                 110         


Arg Ser Ala Arg Pro Pro Arg Gln His Ser Pro Pro Trp Trp Arg Arg 
        115                 120                 125             


<210> 3526
<211> 24
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 3526
Xaa Lys Ile Ser Leu Pro Val Ile Gly Leu Asp Glu Ile Leu Lys Phe 
1               5                   10                  15      


Val Ala Arg Asn Tyr Leu Glu Gly 
            20                  


<210> 3527
<211> 46
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<400> 3527
Leu Ile Phe Gln Ile Xaa Pro Leu Asn Val Xaa Gln Trp Leu Met Val 
1               5                   10                  15      


Leu Lys Ile Ser Leu Pro Val Ile Leu Met Asp Glu Xaa Leu Lys Phe 
            20                  25                  30          


Val Ala Arg Asn Tyr Leu Glu Pro Val Leu Ser Ser Glu Leu 
        35                  40                  45      


<210> 3528
<211> 997
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<400> 3528
Met Glu Asn Ala His Xaa Lys Xaa Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Xaa Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Xaa 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Xaa Ile Xaa Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Xaa Ser Ile Lys Ser Xaa Xaa Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Xaa Gly Glu Ser Val Ser Val Ile Lys His Xaa Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Xaa Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Xaa Gly Val Asn Xaa Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Xaa Glu Gln Glu Arg Xaa Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Xaa Xaa Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Xaa Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Xaa Leu Gly Cys Xaa Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Xaa Gly Xaa Leu Xaa Xaa Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Arg Val Glu Gly Asp Xaa Cys Ser Leu Asn Glu Phe Xaa Ile 
    370                 375                 380                 


Xaa Gly Ser Xaa Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Xaa Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Xaa Glu Xaa Ala Leu Xaa Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Xaa Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Xaa Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Xaa Pro Asn Lys Pro Ser Arg Xaa Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Xaa His Ile Arg 
        515                 520                 525             


Val Gly Ser Xaa Lys Val Pro Met Xaa Ser Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Xaa Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Xaa His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Xaa Asn Leu Xaa Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Xaa 
    610                 615                 620                 


Gly Asp Asn Lys Gly Xaa Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Xaa Ser Lys Ala Phe Xaa Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Xaa Ala Met Xaa Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Xaa Ala Val Ala Lys Xaa Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Xaa Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Xaa Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Xaa Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Xaa Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Xaa Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Xaa Met Ala Leu Ser Val Leu Val Xaa Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Xaa Pro 
945                 950                 955                 960 


Leu Asn Val Xaa Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Xaa Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Pro Ala Ile Leu Glu 
        995         


<210> 3529
<211> 1042
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<400> 3529
Met Glu Asn Ala His Xaa Lys Xaa Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Xaa Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Xaa 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Xaa Ile Xaa Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Xaa Ser Ile Lys Ser Xaa Xaa Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Xaa Gly Glu Ser Val Ser Val Ile Lys His Xaa Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Xaa Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Xaa Gly Val Asn Xaa Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Xaa Glu Gln Glu Arg Xaa Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Xaa Xaa Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Xaa Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Xaa Leu Gly Cys Xaa Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Xaa Gly Xaa Leu Xaa Xaa Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Arg Val Glu Gly Asp Xaa Cys Ser Leu Asn Glu Phe Xaa Ile 
    370                 375                 380                 


Xaa Gly Ser Xaa Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Xaa Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Xaa Glu Xaa Ala Leu Xaa Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Xaa Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Xaa Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Xaa Pro Asn Lys Pro Ser Arg Xaa Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Xaa His Ile Arg 
        515                 520                 525             


Val Gly Ser Xaa Lys Val Pro Met Xaa Ser Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Xaa Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Xaa His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Xaa Asn Leu Xaa Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Xaa 
    610                 615                 620                 


Gly Asp Asn Lys Gly Xaa Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Xaa Ser Lys Ala Phe Xaa Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Xaa Ala Met Xaa Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Xaa Ala Val Ala Lys Xaa Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Xaa Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Xaa Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Xaa Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Xaa Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Xaa Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Xaa Met Ala Leu Ser Val Leu Val Xaa Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Xaa Pro 
945                 950                 955                 960 


Leu Asn Val Xaa Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Xaa Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Pro Gly Lys Glu Cys Val Gln Pro  Ala Xaa Lys Ser Cys  Ser Phe Ser 
        995                 1000                 1005             


Ala Cys  Xaa Asp Gly Ile Ser  Trp Pro Phe Val Leu  Leu Ile Met 
    1010                 1015                 1020             


Pro Leu  Val Ile Trp Val Tyr  Ser Xaa Asp Xaa Asn  Phe Ser Asp 
    1025                 1030                 1035             


Met Phe  Trp Ser 
    1040         


<210> 3530
<211> 50
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<400> 3530
Met Glu Asn Ala His Xaa Lys Xaa Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Xaa Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Gly Arg Cys Arg Glu Lys Pro Cys Trp 
        35                  40                  45              


Asn Leu 
    50  


<210> 3531
<211> 44
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<400> 3531
Met Gln Leu Trp Val Tyr Gly Arg Lys Glu Met Leu Lys Met Pro Ser 
1               5                   10                  15      


Lys Pro Leu Arg Asn Met Ser Leu Lys Trp Ala Lys Cys Ile Asp Arg 
            20                  25                  30          


Xaa Glu Arg Val Cys Ser Gly Leu Lys Leu Lys Xaa 
        35                  40                  


<210> 3532
<211> 933
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (873)..(873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(925)
<223> Selenocysteine

<400> 3532
Xaa Xaa Ile Xaa Ala Phe Val Glu Pro Phe Val Ile Leu Leu Ile Leu 
1               5                   10                  15      


Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala Glu Asn 
            20                  25                  30          


Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys Val Tyr 
        35                  40                  45              


Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp Ile Val 
    50                  55                  60                  


Pro Gly Asp Ile Val Glu Ile Ala Gly Glu Ser Val Ser Val Ile Lys 
65                  70                  75                  80  


His Xaa Asp Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys 
                85                  90                  95      


Asn Met Leu Phe Ser Gly Xaa Asn Ile Ala Ala Gly Lys Ala Met Gly 
            100                 105                 110         


Val Val Val Ala Xaa Gly Val Asn Xaa Glu Ile Gly Lys Ile Arg Asp 
        115                 120                 125             


Glu Met Val Ala Xaa Glu Gln Glu Arg Xaa Pro Leu Gln Gln Lys Leu 
    130                 135                 140                 


Asp Glu Phe Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile 
145                 150                 155                 160 


Ala Val Trp Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly 
                165                 170                 175     


Gly Ser Trp Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala 
            180                 185                 190         


Leu Ala Val Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Xaa Xaa 
        195                 200                 205             


Cys Leu Ala Leu Gly Xaa Arg Arg Met Ala Lys Lys Asn Ala Ile Val 
    210                 215                 220                 


Arg Ser Leu Pro Ser Val Glu Xaa Leu Gly Cys Xaa Ser Val Ile Cys 
225                 230                 235                 240 


Ser Asp Lys Xaa Gly Xaa Leu Xaa Xaa Asn Gln Met Ser Val Cys Arg 
                245                 250                 255     


Met Phe Ile Leu Asp Arg Val Glu Gly Asp Xaa Cys Ser Leu Asn Glu 
            260                 265                 270         


Phe Xaa Ile Xaa Gly Ser Xaa Tyr Ala Pro Ile Gly Glu Val His Lys 
        275                 280                 285             


Asp Asp Lys Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu 
    290                 295                 300                 


Ala Xaa Ile Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu 
305                 310                 315                 320 


Ala Lys Gly Val Tyr Glu Lys Val Gly Glu Ala Xaa Glu Xaa Ala Leu 
                325                 330                 335     


Xaa Cys Leu Val Glu Lys Met Asn Val Phe Asp Xaa Glu Leu Lys Gly 
            340                 345                 350         


Leu Ser Lys Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln 
        355                 360                 365             


Leu Met Lys Lys Glu Phe Xaa Leu Glu Phe Ser Arg Asp Arg Lys Ser 
    370                 375                 380                 


Met Ser Val Tyr Cys Xaa Pro Asn Lys Pro Ser Arg Xaa Ser Met Ser 
385                 390                 395                 400 


Lys Met Phe Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Xaa 
                405                 410                 415     


His Ile Arg Val Gly Ser Xaa Lys Val Pro Met Xaa Ser Gly Val Lys 
            420                 425                 430         


Gln Lys Ile Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Xaa 
        435                 440                 445             


Leu Arg Cys Leu Ala Leu Ala Xaa His Asp Asn Pro Leu Arg Arg Glu 
    450                 455                 460                 


Glu Met His Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Xaa Asn 
465                 470                 475                 480 


Leu Xaa Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu 
                485                 490                 495     


Val Ala Ser Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile 
            500                 505                 510         


Met Ile Xaa Gly Asp Asn Lys Gly Xaa Ala Val Ala Ile Cys Arg Arg 
        515                 520                 525             


Ile Gly Ile Phe Gly Gln Asp Glu Asp Val Xaa Ser Lys Ala Phe Xaa 
    530                 535                 540                 


Gly Arg Glu Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys 
545                 550                 555                 560 


Leu Asn Ala Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys 
                565                 570                 575     


Ile Val Glu Phe Leu Gln Ser Phe Asp Glu Ile Xaa Ala Met Xaa Gly 
            580                 585                 590         


Asp Gly Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile 
        595                 600                 605             


Ala Met Gly Ser Gly Xaa Ala Val Ala Lys Xaa Ala Ser Glu Met Val 
    610                 615                 620                 


Leu Ala Asp Asp Asn Phe Ser Xaa Ile Val Ala Ala Val Glu Glu Gly 
625                 630                 635                 640 


Arg Ala Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser 
                645                 650                 655     


Ser Asn Val Gly Glu Val Val Cys Ile Phe Leu Xaa Ala Ala Leu Gly 
            660                 665                 670         


Phe Pro Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val 
        675                 680                 685             


Xaa Asp Gly Leu Pro Ala Xaa Ala Leu Gly Phe Asn Pro Pro Asp Leu 
    690                 695                 700                 


Asp Ile Met Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser 
705                 710                 715                 720 


Gly Trp Leu Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala 
                725                 730                 735     


Ala Xaa Val Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly 
            740                 745                 750         


Pro Arg Val Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu 
        755                 760                 765             


Asp Asn Pro Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro 
    770                 775                 780                 


Tyr Pro Met Xaa Met Ala Leu Ser Val Leu Val Xaa Ile Glu Met Cys 
785                 790                 795                 800 


Asn Ala Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro 
                805                 810                 815     


Pro Trp Glu Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser 
            820                 825                 830         


Leu His Phe Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln 
        835                 840                 845             


Ile Xaa Pro Leu Asn Val Xaa Gln Trp Leu Met Val Leu Lys Ile Ser 
    850                 855                 860                 


Leu Pro Val Ile Leu Met Asp Glu Xaa Leu Lys Phe Val Ala Arg Asn 
865                 870                 875                 880 


Tyr Leu Glu Pro Gly Lys Glu Cys Val Gln Pro Ala Xaa Lys Ser Cys 
                885                 890                 895     


Ser Phe Ser Ala Cys Xaa Asp Gly Ile Ser Trp Pro Phe Val Leu Leu 
            900                 905                 910         


Ile Met Pro Leu Val Ile Trp Val Tyr Ser Xaa Asp Xaa Asn Phe Ser 
        915                 920                 925             


Asp Met Phe Trp Ser 
    930             


<210> 3533
<211> 1170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1151)
<223> Selenocysteine

<400> 3533
Met Xaa Asn Pro Ser Asp Arg Val Leu Pro Ala Asn Ser Met Ala Glu 
1               5                   10                  15      


Ser Arg Glu Gly Asp Phe Gly Cys Xaa Val Met Glu Leu Arg Lys Leu 
            20                  25                  30          


Met Glu Leu Arg Ser Arg Asp Ala Leu Xaa Gln Ile Asn Val His Tyr 
        35                  40                  45              


Gly Gly Val Gln Asn Leu Cys Ser Arg Leu Lys Xaa Ser Pro Val Glu 
    50                  55                  60                  


Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Lys Arg Arg Gln Val Phe 
65                  70                  75                  80  


Gly His Asn Val Ile Pro Pro Lys Lys Pro Lys Xaa Phe Leu Glu Leu 
                85                  90                  95      


Val Trp Glu Ala Leu Gln Asp Val Xaa Leu Ile Ile Leu Glu Ile Ala 
            100                 105                 110         


Ala Ile Ile Ser Leu Val Leu Ser Phe Tyr Arg Pro Ala Gly Glu Glu 
        115                 120                 125             


Asn Glu Leu Cys Gly Gln Val Ala Xaa Xaa Pro Glu Asp Glu Asn Glu 
    130                 135                 140                 


Ala Gln Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Phe Ser Val Ile 
145                 150                 155                 160 


Ile Val Val Leu Val Xaa Ala Phe Asn Asp Trp Ser Lys Glu Lys Gln 
                165                 170                 175     


Phe Arg Gly Leu Gln Cys Arg Ile Glu Gln Glu Gln Lys Phe Ser Ile 
            180                 185                 190         


Ile Arg Asn Gly Gln Leu Ile Gln Leu Pro Val Ala Glu Ile Val Val 
        195                 200                 205             


Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala Asp Gly 
    210                 215                 220                 


Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser Leu Xaa 
225                 230                 235                 240 


Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys Asp Pro Met Leu 
                245                 250                 255     


Leu Ser Gly Xaa His Val Met Glu Gly Ser Gly Arg Met Val Val Xaa 
            260                 265                 270         


Ala Val Gly Val Asn Ser Gln Xaa Gly Ile Ile Leu Xaa Leu Leu Gly 
        275                 280                 285             


Val Asn Glu Asp Asp Glu Gly Glu Lys Lys Lys Lys Gly Lys Lys Gln 
    290                 295                 300                 


Gly Val Pro Glu Asn Arg Asn Lys Ala Lys Xaa Gln Asp Gly Val Ala 
305                 310                 315                 320 


Leu Glu Ile Gln Pro Leu Asn Ser Gln Glu Gly Ile Asp Asn Glu Glu 
                325                 330                 335     


Lys Asp Lys Lys Ala Val Lys Val Pro Lys Lys Glu Lys Ser Val Leu 
            340                 345                 350         


Gln Gly Lys Leu Xaa Arg Leu Ala Val Gln Ile Gly Lys Ala Gly Leu 
        355                 360                 365             


Leu Met Ser Ala Leu Xaa Val Phe Ile Leu Ile Leu Tyr Phe Val Ile 
    370                 375                 380                 


Asp Asn Phe Val Ile Asn Arg Arg Pro Trp Leu Pro Glu Cys Xaa Pro 
385                 390                 395                 400 


Ile Tyr Ile Gln Tyr Phe Val Lys Phe Phe Ile Ile Gly Ile Xaa Val 
                405                 410                 415     


Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala Val Xaa Ile Ser 
            420                 425                 430         


Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn Asn Leu Val Arg 
        435                 440                 445             


His Leu Asp Ala Cys Glu Xaa Met Gly Asn Ala Xaa Ala Ile Cys Ser 
    450                 455                 460                 


Asp Lys Xaa Gly Xaa Leu Xaa Met Asn Arg Met Xaa Val Val Gln Ala 
465                 470                 475                 480 


Tyr Ile Gly Gly Ile His Tyr Arg Gln Ile Pro Ser Pro Asp Val Phe 
                485                 490                 495     


Leu Pro Lys Val Leu Asp Leu Ile Val Asn Gly Ile Ser Ile Asn Ser 
            500                 505                 510         


Ala Tyr Xaa Ser Lys Ile Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro 
        515                 520                 525             


Arg Gln Val Gly Asn Lys Xaa Glu Cys Ala Leu Leu Gly Phe Val Xaa 
    530                 535                 540                 


Asp Leu Lys Gln Asp Tyr Gln Ala Val Arg Asn Glu Val Pro Glu Glu 
545                 550                 555                 560 


Lys Leu Tyr Lys Val Tyr Xaa Phe Asn Ser Val Arg Lys Ser Met Ser 
                565                 570                 575     


Xaa Val Ile Arg Asn Pro Asn Gly Gly Phe Arg Met Tyr Ser Lys Gly 
            580                 585                 590         


Ala Ser Glu Ile Ile Leu Arg Lys Cys Asn Arg Ile Leu Asp Arg Lys 
        595                 600                 605             


Gly Glu Ala Val Pro Phe Lys Asn Lys Asp Arg Asp Asp Met Val Arg 
    610                 615                 620                 


Xaa Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg Xaa Ile Cys Ile 
625                 630                 635                 640 


Ala Tyr Arg Asp Phe Asp Asp Xaa Glu Pro Ser Trp Asp Asn Glu Asn 
                645                 650                 655     


Glu Ile Leu Xaa Glu Leu Xaa Cys Ile Ala Val Val Gly Ile Glu Asp 
            660                 665                 670         


Pro Val Arg Pro Glu Val Pro Asp Ala Ile Ala Lys Cys Lys Gln Ala 
        675                 680                 685             


Gly Ile Xaa Val Arg Met Val Xaa Gly Asp Asn Ile Asn Xaa Ala Arg 
    690                 695                 700                 


Ala Ile Ala Xaa Lys Cys Gly Ile Leu Xaa Pro Gly Asp Asp Phe Leu 
705                 710                 715                 720 


Cys Leu Glu Gly Lys Glu Phe Asn Arg Leu Ile Arg Asn Glu Lys Gly 
                725                 730                 735     


Glu Val Glu Gln Glu Lys Leu Asp Lys Ile Trp Pro Lys Leu Arg Val 
            740                 745                 750         


Leu Ala Arg Ser Ser Pro Xaa Asp Lys His Xaa Leu Val Lys Gly Ile 
        755                 760                 765             


Ile Asp Ser Xaa Val Gly Glu His Arg Gln Val Val Ala Val Xaa Gly 
    770                 775                 780                 


Asp Gly Xaa Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe 
785                 790                 795                 800 


Ala Met Gly Ile Ala Gly Xaa Asp Val Ala Lys Glu Ala Ser Asp Ile 
                805                 810                 815     


Ile Leu Xaa Asp Asp Asn Phe Xaa Ser Ile Val Lys Ala Val Met Trp 
            820                 825                 830         


Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu 
        835                 840                 845             


Xaa Val Asn Val Val Ala Val Ile Val Ala Phe Xaa Gly Ala Cys Ile 
    850                 855                 860                 


Xaa Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu 
865                 870                 875                 880 


Ile Met Asp Xaa Phe Ala Ser Leu Ala Leu Ala Xaa Glu Pro Pro Xaa 
                885                 890                 895     


Glu Ser Leu Leu Lys Arg Arg Pro Tyr Gly Arg Asn Lys Pro Leu Ile 
            900                 905                 910         


Ser Arg Xaa Met Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu 
        915                 920                 925             


Ile Val Ile Phe Ile Leu Val Phe Ala Gly Glu Lys Phe Phe Asp Ile 
    930                 935                 940                 


Asp Ser Gly Arg Lys Ala Pro Leu His Ser Pro Pro Ser Gln His Tyr 
945                 950                 955                 960 


Xaa Ile Val Phe Asn Xaa Phe Val Leu Met Gln Leu Phe Asn Glu Ile 
                965                 970                 975     


Asn Ser Arg Lys Ile His Gly Glu Lys Asn Val Phe Ser Gly Ile Tyr 
            980                 985                 990         


Arg Asn Ile Ile Phe Cys Ser Val  Val Leu Gly Xaa Phe  Ile Cys Gln 
        995                 1000                 1005             


Ile Phe  Ile Val Glu Phe Gly  Gly Lys Pro Phe Ser  Cys Xaa Ser 
    1010                 1015                 1020             


Leu Ser  Leu Ser Gln Trp Leu  Trp Cys Leu Phe Ile  Gly Ile Gly 
    1025                 1030                 1035             


Glu Leu  Leu Trp Gly Gln Phe  Ile Ser Ala Ile Pro  Xaa Arg Ser 
    1040                 1045                 1050             


Leu Lys  Phe Leu Lys Glu Ala  Gly His Gly Xaa Xaa  Lys Glu Glu 
    1055                 1060                 1065             


Ile Xaa  Lys Asp Ala Glu Gly  Leu Asp Glu Ile Asp  His Ala Glu 
    1070                 1075                 1080             


Met Glu  Leu Arg Arg Gly Gln  Ile Leu Trp Phe Arg  Gly Leu Asn 
    1085                 1090                 1095             


Arg Ile  Gln Xaa Gln Ile Asp  Val Ile Asn Xaa Phe  Gln Xaa Gly 
    1100                 1105                 1110             


Ala Ser  Phe Lys Gly Val Leu  Arg Arg Gln Asn Met  Gly Gln His 
    1115                 1120                 1125             


Leu Asp  Val Lys Leu Val Pro  Ser Ser Ser Tyr Val  Ala Val Ala 
    1130                 1135                 1140             


Pro Val  Lys Ser Ser Pro Xaa  Xaa Ser Val Pro Ala  Val Ser Ser 
    1145                 1150                 1155             


Pro Pro  Met Gly Asn Gln Ser  Gly Gln Ser Val Pro  
    1160                 1165                 1170 


<210> 3534
<211> 1205
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1145)..(1145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1179)..(1179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<400> 3534
Met Xaa Asn Pro Ser Asp Arg Val Leu Pro Ala Asn Ser Met Ala Glu 
1               5                   10                  15      


Ser Arg Glu Gly Asp Phe Gly Cys Xaa Val Met Glu Leu Arg Lys Leu 
            20                  25                  30          


Met Glu Leu Arg Ser Arg Asp Ala Leu Xaa Gln Ile Asn Val His Tyr 
        35                  40                  45              


Gly Gly Val Gln Asn Leu Cys Ser Arg Leu Lys Xaa Ser Pro Val Glu 
    50                  55                  60                  


Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Lys Arg Arg Gln Val Phe 
65                  70                  75                  80  


Gly His Asn Val Ile Pro Pro Lys Lys Pro Lys Xaa Phe Leu Glu Leu 
                85                  90                  95      


Val Trp Glu Ala Leu Gln Asp Val Xaa Leu Ile Ile Leu Glu Ile Ala 
            100                 105                 110         


Ala Ile Ile Ser Leu Val Leu Ser Phe Tyr Arg Pro Ala Gly Glu Glu 
        115                 120                 125             


Asn Glu Leu Cys Gly Gln Val Ala Xaa Xaa Pro Glu Asp Glu Asn Glu 
    130                 135                 140                 


Ala Gln Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Phe Ser Val Ile 
145                 150                 155                 160 


Ile Val Val Leu Val Xaa Ala Phe Asn Asp Trp Ser Lys Glu Lys Gln 
                165                 170                 175     


Phe Arg Gly Leu Gln Cys Arg Ile Glu Gln Glu Gln Lys Phe Ser Ile 
            180                 185                 190         


Ile Arg Asn Gly Gln Leu Ile Gln Leu Pro Val Ala Glu Ile Val Val 
        195                 200                 205             


Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala Asp Gly 
    210                 215                 220                 


Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser Leu Xaa 
225                 230                 235                 240 


Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys Asp Pro Met Leu 
                245                 250                 255     


Leu Ser Gly Xaa His Val Met Glu Gly Ser Gly Arg Met Val Val Xaa 
            260                 265                 270         


Ala Val Gly Val Asn Ser Gln Xaa Gly Ile Ile Leu Xaa Leu Leu Gly 
        275                 280                 285             


Val Asn Glu Asp Asp Glu Gly Glu Lys Lys Lys Lys Gly Lys Lys Gln 
    290                 295                 300                 


Gly Val Pro Glu Asn Arg Asn Lys Ala Lys Xaa Gln Asp Gly Val Ala 
305                 310                 315                 320 


Leu Glu Ile Gln Pro Leu Asn Ser Gln Glu Gly Ile Asp Asn Glu Glu 
                325                 330                 335     


Lys Asp Lys Lys Ala Val Lys Val Pro Lys Lys Glu Lys Ser Val Leu 
            340                 345                 350         


Gln Gly Lys Leu Xaa Arg Leu Ala Val Gln Ile Gly Lys Ala Gly Leu 
        355                 360                 365             


Leu Met Ser Ala Leu Xaa Val Phe Ile Leu Ile Leu Tyr Phe Val Ile 
    370                 375                 380                 


Asp Asn Phe Val Ile Asn Arg Arg Pro Trp Leu Pro Glu Cys Xaa Pro 
385                 390                 395                 400 


Ile Tyr Ile Gln Tyr Phe Val Lys Phe Phe Ile Ile Gly Ile Xaa Val 
                405                 410                 415     


Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala Val Xaa Ile Ser 
            420                 425                 430         


Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn Asn Leu Val Arg 
        435                 440                 445             


His Leu Asp Ala Cys Glu Xaa Met Gly Asn Ala Xaa Ala Ile Cys Ser 
    450                 455                 460                 


Asp Lys Xaa Gly Xaa Leu Xaa Met Asn Arg Met Xaa Val Val Gln Ala 
465                 470                 475                 480 


Tyr Ile Gly Gly Ile His Tyr Arg Gln Ile Pro Ser Pro Asp Val Phe 
                485                 490                 495     


Leu Pro Lys Val Leu Asp Leu Ile Val Asn Gly Ile Ser Ile Asn Ser 
            500                 505                 510         


Ala Tyr Xaa Ser Lys Ile Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro 
        515                 520                 525             


Arg Gln Val Gly Asn Lys Xaa Glu Cys Ala Leu Leu Gly Phe Val Xaa 
    530                 535                 540                 


Asp Leu Lys Gln Asp Tyr Gln Ala Val Arg Asn Glu Val Pro Glu Glu 
545                 550                 555                 560 


Lys Leu Tyr Lys Val Tyr Xaa Phe Asn Ser Val Arg Lys Ser Met Ser 
                565                 570                 575     


Xaa Val Ile Arg Asn Pro Asn Gly Gly Phe Arg Met Tyr Ser Lys Gly 
            580                 585                 590         


Ala Ser Glu Ile Ile Leu Arg Lys Cys Asn Arg Ile Leu Asp Arg Lys 
        595                 600                 605             


Gly Glu Ala Val Pro Phe Lys Asn Lys Asp Arg Asp Asp Met Val Arg 
    610                 615                 620                 


Xaa Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg Xaa Ile Cys Ile 
625                 630                 635                 640 


Ala Tyr Arg Asp Phe Asp Asp Xaa Glu Pro Ser Trp Asp Asn Glu Asn 
                645                 650                 655     


Glu Ile Leu Xaa Glu Leu Xaa Cys Ile Ala Val Val Gly Ile Glu Asp 
            660                 665                 670         


Pro Val Arg Pro Glu Val Pro Asp Ala Ile Ala Lys Cys Lys Gln Ala 
        675                 680                 685             


Gly Ile Xaa Val Arg Met Val Xaa Gly Asp Asn Ile Asn Xaa Ala Arg 
    690                 695                 700                 


Ala Ile Ala Xaa Lys Cys Gly Ile Leu Xaa Pro Gly Asp Asp Phe Leu 
705                 710                 715                 720 


Cys Leu Glu Gly Lys Glu Phe Asn Arg Leu Ile Arg Asn Glu Lys Gly 
                725                 730                 735     


Glu Val Glu Gln Glu Lys Leu Asp Lys Ile Trp Pro Lys Leu Arg Val 
            740                 745                 750         


Leu Ala Arg Ser Ser Pro Xaa Asp Lys His Xaa Leu Val Lys Gly Ile 
        755                 760                 765             


Ile Asp Ser Xaa Val Gly Glu His Arg Gln Val Val Ala Val Xaa Gly 
    770                 775                 780                 


Asp Gly Xaa Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe 
785                 790                 795                 800 


Ala Met Gly Ile Ala Gly Xaa Asp Val Ala Lys Glu Ala Ser Asp Ile 
                805                 810                 815     


Ile Leu Xaa Asp Asp Asn Phe Xaa Ser Ile Val Lys Ala Val Met Trp 
            820                 825                 830         


Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu 
        835                 840                 845             


Xaa Val Asn Val Val Ala Val Ile Val Ala Phe Xaa Gly Ala Cys Ile 
    850                 855                 860                 


Xaa Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu 
865                 870                 875                 880 


Ile Met Asp Xaa Phe Ala Ser Leu Ala Leu Ala Xaa Glu Pro Pro Xaa 
                885                 890                 895     


Glu Ser Leu Leu Lys Arg Arg Pro Tyr Gly Arg Asn Lys Pro Leu Ile 
            900                 905                 910         


Ser Arg Xaa Met Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu 
        915                 920                 925             


Ile Val Ile Phe Ile Leu Val Phe Ala Gly Glu Lys Phe Phe Asp Ile 
    930                 935                 940                 


Asp Ser Gly Arg Lys Ala Pro Leu His Ser Pro Pro Ser Gln His Tyr 
945                 950                 955                 960 


Xaa Ile Val Phe Asn Xaa Phe Val Leu Met Gln Leu Phe Asn Glu Ile 
                965                 970                 975     


Asn Ser Arg Lys Ile His Gly Glu Lys Asn Val Phe Ser Gly Ile Tyr 
            980                 985                 990         


Arg Asn Ile Ile Phe Cys Ser Val  Val Leu Gly Xaa Phe  Ile Cys Gln 
        995                 1000                 1005             


Ile Phe  Ile Val Glu Phe Gly  Gly Lys Pro Phe Ser  Cys Xaa Ser 
    1010                 1015                 1020             


Leu Ser  Leu Ser Gln Trp Leu  Trp Cys Leu Phe Ile  Gly Ile Gly 
    1025                 1030                 1035             


Glu Leu  Leu Trp Gly Gln Phe  Ile Ser Ala Ile Pro  Xaa Arg Ser 
    1040                 1045                 1050             


Leu Lys  Phe Leu Lys Glu Ala  Gly His Gly Xaa Xaa  Lys Glu Glu 
    1055                 1060                 1065             


Ile Xaa  Lys Asp Ala Glu Gly  Leu Asp Glu Ile Asp  His Ala Glu 
    1070                 1075                 1080             


Met Glu  Leu Arg Arg Gly Gln  Ile Leu Trp Phe Arg  Gly Leu Asn 
    1085                 1090                 1095             


Arg Ile  Gln Xaa Gln Ile Lys  Val Val Lys Ala Phe  His Ser Ser 
    1100                 1105                 1110             


Leu His  Glu Ser Ile Gln Lys  Pro Tyr Asn Gln Lys  Ser Ile His 
    1115                 1120                 1125             


Ser Phe  Met Xaa His Pro Glu  Phe Ala Ile Glu Glu  Glu Leu Pro 
    1130                 1135                 1140             


Arg Xaa  Pro Leu Leu Asp Glu  Glu Glu Glu Glu Asn  Pro Asp Lys 
    1145                 1150                 1155             


Ala Ser  Lys Phe Gly Xaa Arg  Val Leu Leu Leu Asp  Gly Glu Val 
    1160                 1165                 1170             


Xaa Pro  Tyr Ala Asn Xaa Asn  Asn Asn Ala Val Asp  Cys Asn Gln 
    1175                 1180                 1185             


Val Gln  Leu Pro Gln Ser Asp  Ser Ser Leu Gln Ser  Leu Glu Xaa 
    1190                 1195                 1200             


Ser Val  
    1205 


<210> 3535
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 3535
Xaa Gly Gly Lys Pro Phe Ser Cys Xaa Ser Leu Ser Leu Ser Gln Trp 
1               5                   10                  15      


Leu Trp Cys Leu Phe Ile Gly Ile Gly Glu Leu Leu Trp Gly Gln Phe 
            20                  25                  30          


Ile Ser Ala Ile Pro Xaa Arg Ser Leu Lys Phe Leu Lys Glu Ala Gly 
        35                  40                  45              


His Gly Xaa Xaa Lys Glu Glu Ile Xaa Lys Asp Ala Glu Gly Leu Asp 
    50                  55                  60                  


Glu Ile Asp His Ala Glu Met Glu Leu Arg Arg Gly Gln Ile Leu Trp 
65                  70                  75                  80  


Phe Arg Gly Leu Asn Arg Ile Gln Xaa Gln His Leu Leu Gln Asp Ser 
                85                  90                  95      


Asp Leu Leu Pro Asp Lys Glu Glu Ala Ile Ile Ser Ser Ser Leu Phe 
            100                 105                 110         


Pro Ser Cys Asn Phe 
        115         


<210> 3536
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(116)
<223> Selenocysteine

<400> 3536
Xaa Ile Gly Glu Leu Leu Trp Gly Gln Phe Ile Ser Ala Ile Pro Xaa 
1               5                   10                  15      


Arg Ser Leu Lys Phe Leu Lys Glu Ala Gly His Gly Xaa Xaa Lys Glu 
            20                  25                  30          


Glu Ile Xaa Lys Asp Ala Glu Gly Leu Asp Glu Ile Asp His Ala Glu 
        35                  40                  45              


Met Glu Leu Arg Arg Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg 
    50                  55                  60                  


Ile Gln Xaa Gln Ile Asp Val Ile Asn Xaa Phe Gln Xaa Gly Ala Ser 
65                  70                  75                  80  


Phe Lys Gly Val Leu Arg Arg Gln Asn Met Gly Gln His Leu Asp Val 
                85                  90                  95      


Lys Leu Val Pro Ser Ser Ser Tyr Val Ala Val Ala Pro Val Lys Ser 
            100                 105                 110         


Ser Pro Xaa Xaa Ser Val Pro Ala Val Ser Ser Pro Pro Met Gly Ser 
        115                 120                 125             


Glu 
    


<210> 3537
<211> 102
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(83)
<223> Selenocysteine

<400> 3537
Xaa Xaa Lys Asp Ala Glu Gly Leu Asp Glu Ile Asp His Ala Glu Met 
1               5                   10                  15      


Glu Leu Arg Arg Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile 
            20                  25                  30          


Gln Xaa Gln Ile Asp Val Ile Asn Xaa Phe Gln Xaa Gly Ala Ser Phe 
        35                  40                  45              


Lys Gly Val Leu Arg Arg Gln Asn Met Gly Gln His Leu Asp Val Lys 
    50                  55                  60                  


Leu Val Pro Ser Ser Ser Tyr Val Ala Val Ala Pro Val Lys Ser Ser 
65                  70                  75                  80  


Pro Xaa Xaa Ser Val Pro Ala Val Ser Ser Pro Pro Met Gly Asn Gln 
                85                  90                  95      


Ser Gly Gln Ser Val Pro 
            100         


<210> 3538
<211> 50
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<400> 3538
Leu Val Asp Asp Asp Phe Gln Xaa Ile Met Ser Ala Ile Glu Glu Gly 
1               5                   10                  15      


Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg Phe Gln Leu Ser 
            20                  25                  30          


Xaa Phe Cys Gly Ser Ile Leu Leu Trp Met Asp Pro Gln Leu Arg Ala 
        35                  40                  45              


Leu Glu 
    50  


<210> 3539
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 3539
Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr Ser Phe Gly Ile Ile 
1               5                   10                  15      


Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly Lys Asp Ile Leu Glu 
            20                  25                  30          


Met Phe Xaa Ile Ser Val Ser Leu Ala Val Ala Ala Ile Pro Glu Gly 
        35                  40                  45              


Leu Pro Ile Val Val Xaa Val Xaa Leu Ala Leu Gly Val Met Arg Met 
    50                  55                  60                  


Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro Ile Val Glu Xaa Leu 
65                  70                  75                  80  


Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Xaa Gly Xaa Leu Xaa Lys 
                85                  90                  95      


Asn Glu Met Xaa Val Xaa His Ile Phe Xaa Ser Asp Gly Leu His Ala 
            100                 105                 110         


Glu Val Xaa Gly Val Gly Tyr Asn Gln Phe Gly Glu Val Ile Val Asp 
        115                 120                 125             


Gly Asp Val 
    130     


<210> 3540
<211> 953
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<400> 3540
Met Asp Ser Leu Leu Pro Pro Ser Arg Phe Ser Tyr Phe Lys Lys Tyr 
1               5                   10                  15      


Pro Leu His Ala Ile Arg Arg Tyr Leu Ser Xaa Leu Arg Asn Gln Arg 
            20                  25                  30          


Ala Glu Glu Gln Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn 
        35                  40                  45              


Glu Xaa Met Ile Pro Val Leu Xaa Ser Lys Lys Ala Ser Glu Leu Pro 
    50                  55                  60                  


Val Ser Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu 
65                  70                  75                  80  


Asn Lys Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu 
                85                  90                  95      


Phe Asp Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln 
            100                 105                 110         


Phe Lys Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser 
        115                 120                 125             


Val Leu Met His Gln Phe Asp Asp Ala Val Ser Ile Xaa Val Ala Ile 
    130                 135                 140                 


Leu Ile Val Val Xaa Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys 
145                 150                 155                 160 


Ser Leu Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val 
                165                 170                 175     


Arg Glu Gly Lys Leu Glu His Xaa Leu Ala Arg Asp Leu Val Pro Gly 
            180                 185                 190         


Asp Xaa Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg 
        195                 200                 205             


Leu Phe Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Xaa Gly 
    210                 215                 220                 


Glu Xaa Xaa Pro Cys Ser Lys Val Xaa Ala Pro Gln Pro Ala Ala Xaa 
225                 230                 235                 240 


Asn Gly Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Xaa Leu 
                245                 250                 255     


Val Arg Cys Gly Lys Ala Lys Gly Val Val Ile Gly Xaa Gly Glu Asn 
            260                 265                 270         


Ser Glu Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro 
        275                 280                 285             


Lys Xaa Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser 
    290                 295                 300                 


Phe Tyr Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu 
305                 310                 315                 320 


Leu Gly Lys Asp Ile Leu Glu Met Phe Xaa Ile Ser Val Ser Leu Ala 
                325                 330                 335     


Val Ala Ala Ile Pro Glu Gly Leu Pro Ile Val Val Xaa Val Xaa Leu 
            340                 345                 350         


Ala Leu Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys 
        355                 360                 365             


Leu Pro Ile Val Glu Xaa Leu Gly Cys Cys Asn Val Ile Cys Ser Asp 
    370                 375                 380                 


Lys Xaa Gly Xaa Leu Xaa Lys Asn Glu Met Xaa Val Xaa His Ile Phe 
385                 390                 395                 400 


Xaa Ser Asp Gly Leu His Ala Glu Val Xaa Gly Val Gly Tyr Asn Gln 
                405                 410                 415     


Phe Gly Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn 
            420                 425                 430         


Pro Ala Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala 
        435                 440                 445             


Val Ile Arg Asn Asn Xaa Leu Met Gly Lys Pro Xaa Glu Gly Ala Leu 
    450                 455                 460                 


Ile Ala Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr 
465                 470                 475                 480 


Ile Arg Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala 
                485                 490                 495     


Val Lys Cys Val His Arg Xaa Gln Gln Asp Arg Pro Glu Ile Cys Phe 
            500                 505                 510         


Met Lys Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Xaa Xaa Tyr Gln 
        515                 520                 525             


Ser Lys Gly Gln Xaa Leu Xaa Leu Xaa Gln Gln Gln Arg Asp Val Tyr 
    530                 535                 540                 


Gln Gln Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala 
545                 550                 555                 560 


Leu Ala Ser Gly Pro Glu Leu Gly Gln Leu Xaa Phe Leu Gly Leu Val 
                565                 570                 575     


Gly Ile Ile Asp Pro Pro Arg Xaa Gly Val Lys Glu Ala Val Xaa Xaa 
            580                 585                 590         


Leu Ile Ala Ser Gly Val Ser Ile Lys Met Ile Xaa Gly Asp Ser Gln 
        595                 600                 605             


Glu Xaa Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Xaa 
    610                 615                 620                 


Ser Gln Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln 
625                 630                 635                 640 


Leu Ser Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro 
                645                 650                 655     


Arg His Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val 
            660                 665                 670         


Val Ala Met Xaa Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala 
        675                 680                 685             


Ala Asp Ile Gly Val Ala Met Gly Gln Xaa Gly Xaa Asp Val Cys Lys 
    690                 695                 700                 


Glu Ala Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Xaa Ile Met 
705                 710                 715                 720 


Ser Ala Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe 
                725                 730                 735     


Val Arg Phe Gln Leu Ser Xaa Ser Ile Ala Ala Leu Xaa Leu Ile Ser 
            740                 745                 750         


Leu Ala Xaa Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile 
        755                 760                 765             


Leu Trp Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly 
    770                 775                 780                 


Val Glu Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp 
785                 790                 795                 800 


Lys Asp Ser Ile Leu Xaa Lys Asn Leu Ile Leu Lys Ile Leu Val Ser 
                805                 810                 815     


Ser Ile Ile Ile Val Cys Gly Xaa Leu Phe Val Phe Trp Arg Glu Leu 
            820                 825                 830         


Arg Asp Asn Val Ile Xaa Pro Arg Asp Xaa Xaa Met Xaa Phe Xaa Cys 
        835                 840                 845             


Phe Val Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Xaa 
    850                 855                 860                 


Lys Ser Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr 
865                 870                 875                 880 


Ala Val Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro 
                885                 890                 895     


Pro Leu Gln Lys Val Phe Gln Xaa Glu Ser Leu Ser Ile Leu Asp Leu 
            900                 905                 910         


Leu Phe Leu Leu Gly Leu Xaa Ser Ser Val Cys Ile Val Ala Glu Ile 
        915                 920                 925             


Ile Lys Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser 
    930                 935                 940                 


Ser Xaa Ser Ser Ser Phe Leu Glu Val 
945                 950             


<210> 3541
<211> 973
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<400> 3541
Met Asp Ser Leu Leu Pro Pro Ser Arg Phe Ser Tyr Phe Lys Lys Tyr 
1               5                   10                  15      


Pro Leu His Ala Ile Arg Arg Tyr Leu Ser Xaa Leu Arg Asn Gln Arg 
            20                  25                  30          


Ala Glu Glu Gln Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn 
        35                  40                  45              


Glu Xaa Met Ile Pro Val Leu Xaa Ser Lys Lys Ala Ser Glu Leu Pro 
    50                  55                  60                  


Val Ser Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu 
65                  70                  75                  80  


Asn Lys Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu 
                85                  90                  95      


Phe Asp Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln 
            100                 105                 110         


Phe Lys Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser 
        115                 120                 125             


Val Leu Met His Gln Phe Asp Asp Ala Val Ser Ile Xaa Val Ala Ile 
    130                 135                 140                 


Leu Ile Val Val Xaa Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys 
145                 150                 155                 160 


Ser Leu Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val 
                165                 170                 175     


Arg Glu Gly Lys Leu Glu His Xaa Leu Ala Arg Asp Leu Val Pro Gly 
            180                 185                 190         


Asp Xaa Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg 
        195                 200                 205             


Leu Phe Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Xaa Gly 
    210                 215                 220                 


Glu Xaa Xaa Pro Cys Ser Lys Val Xaa Ala Pro Gln Pro Ala Ala Xaa 
225                 230                 235                 240 


Asn Gly Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Xaa Leu 
                245                 250                 255     


Val Arg Cys Gly Lys Ala Lys Gly Val Val Ile Gly Xaa Gly Glu Asn 
            260                 265                 270         


Ser Glu Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro 
        275                 280                 285             


Lys Xaa Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser 
    290                 295                 300                 


Phe Tyr Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu 
305                 310                 315                 320 


Leu Gly Lys Asp Ile Leu Glu Met Phe Xaa Ile Ser Val Ser Leu Ala 
                325                 330                 335     


Val Ala Ala Ile Pro Glu Gly Leu Pro Ile Val Val Xaa Val Xaa Leu 
            340                 345                 350         


Ala Leu Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys 
        355                 360                 365             


Leu Pro Ile Val Glu Xaa Leu Gly Cys Cys Asn Val Ile Cys Ser Asp 
    370                 375                 380                 


Lys Xaa Gly Xaa Leu Xaa Lys Asn Glu Met Xaa Val Xaa His Ile Phe 
385                 390                 395                 400 


Xaa Ser Asp Gly Leu His Ala Glu Val Xaa Gly Val Gly Tyr Asn Gln 
                405                 410                 415     


Phe Gly Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn 
            420                 425                 430         


Pro Ala Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala 
        435                 440                 445             


Val Ile Arg Asn Asn Xaa Leu Met Gly Lys Pro Xaa Glu Gly Ala Leu 
    450                 455                 460                 


Ile Ala Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr 
465                 470                 475                 480 


Ile Arg Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala 
                485                 490                 495     


Val Lys Cys Val His Arg Xaa Gln Gln Asp Arg Pro Glu Ile Cys Phe 
            500                 505                 510         


Met Lys Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Xaa Xaa Tyr Gln 
        515                 520                 525             


Ser Lys Gly Gln Xaa Leu Xaa Leu Xaa Gln Gln Gln Arg Asp Val Tyr 
    530                 535                 540                 


Gln Gln Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala 
545                 550                 555                 560 


Leu Ala Ser Gly Pro Glu Leu Gly Gln Leu Xaa Phe Leu Gly Leu Val 
                565                 570                 575     


Gly Ile Ile Asp Pro Pro Arg Xaa Gly Val Lys Glu Ala Val Xaa Xaa 
            580                 585                 590         


Leu Ile Ala Ser Gly Val Ser Ile Lys Met Ile Xaa Gly Asp Ser Gln 
        595                 600                 605             


Glu Xaa Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Xaa 
    610                 615                 620                 


Ser Gln Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln 
625                 630                 635                 640 


Leu Ser Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro 
                645                 650                 655     


Arg His Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val 
            660                 665                 670         


Val Ala Met Xaa Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala 
        675                 680                 685             


Ala Asp Ile Gly Val Ala Met Gly Gln Xaa Gly Xaa Asp Val Cys Lys 
    690                 695                 700                 


Glu Ala Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Xaa Ile Met 
705                 710                 715                 720 


Ser Ala Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe 
                725                 730                 735     


Val Arg Phe Gln Leu Ser Xaa Ser Ile Ala Ala Leu Xaa Leu Ile Ser 
            740                 745                 750         


Leu Ala Xaa Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile 
        755                 760                 765             


Leu Trp Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly 
    770                 775                 780                 


Val Glu Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp 
785                 790                 795                 800 


Lys Asp Ser Ile Leu Xaa Lys Asn Leu Ile Leu Lys Ile Leu Val Ser 
                805                 810                 815     


Ser Ile Ile Ile Val Cys Gly Xaa Leu Phe Val Phe Trp Arg Glu Leu 
            820                 825                 830         


Arg Asp Asn Val Ile Xaa Pro Arg Asp Xaa Xaa Met Xaa Phe Xaa Cys 
        835                 840                 845             


Phe Val Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Xaa 
    850                 855                 860                 


Lys Ser Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr 
865                 870                 875                 880 


Ala Val Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro 
                885                 890                 895     


Pro Leu Gln Lys Val Phe Gln Xaa Glu Ser Leu Ser Ile Leu Asp Leu 
            900                 905                 910         


Leu Phe Leu Leu Gly Leu Xaa Ser Ser Val Cys Ile Val Ala Glu Ile 
        915                 920                 925             


Ile Lys Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Trp 
    930                 935                 940                 


Leu Trp Glu Arg Ser Gly Gln Gln Leu Val Glu Ile His Pro His Leu 
945                 950                 955                 960 


Glu Xaa Gly Leu Pro Leu Xaa Glu Asp Val Ser Cys Val 
                965                 970             


<210> 3542
<211> 944
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<400> 3542
Met Asp Ser Leu Leu Pro Pro Ser Arg Phe Ser Tyr Phe Lys Lys Tyr 
1               5                   10                  15      


Pro Leu His Ala Ile Arg Arg Tyr Leu Ser Xaa Leu Arg Asn Gln Arg 
            20                  25                  30          


Ala Glu Glu Gln Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn 
        35                  40                  45              


Glu Xaa Met Ile Pro Val Leu Xaa Ser Lys Lys Ala Ser Glu Leu Pro 
    50                  55                  60                  


Val Ser Glu Val Ala Ser Ile Leu Gln Phe Lys Asn Pro Leu Ile Met 
65                  70                  75                  80  


Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu Met His Gln Phe Asp 
                85                  90                  95      


Asp Ala Val Ser Ile Xaa Val Ala Ile Leu Ile Val Val Xaa Val Ala 
            100                 105                 110         


Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu Glu Glu Leu Ser Lys 
        115                 120                 125             


Leu Val Pro Pro Glu Cys His Cys Val Arg Glu Gly Lys Leu Glu His 
    130                 135                 140                 


Xaa Leu Ala Arg Asp Leu Val Pro Gly Asp Xaa Val Cys Leu Ser Val 
145                 150                 155                 160 


Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe Glu Ala Val Asp Leu 
                165                 170                 175     


Ser Ile Asp Glu Ser Ser Leu Xaa Gly Glu Xaa Xaa Pro Cys Ser Lys 
            180                 185                 190         


Val Xaa Ala Pro Gln Pro Ala Ala Xaa Asn Gly Asp Leu Ala Ser Arg 
        195                 200                 205             


Ser Asn Ile Ala Phe Met Gly Xaa Leu Val Arg Cys Gly Lys Ala Lys 
    210                 215                 220                 


Gly Val Val Ile Gly Xaa Gly Glu Asn Ser Glu Phe Gly Glu Val Phe 
225                 230                 235                 240 


Lys Met Met Gln Ala Glu Glu Ala Pro Lys Xaa Pro Leu Gln Lys Ser 
                245                 250                 255     


Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr Ser Phe Gly Ile Ile 
            260                 265                 270         


Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly Lys Asp Ile Leu Glu 
        275                 280                 285             


Met Phe Xaa Ile Ser Val Ser Leu Ala Val Ala Ala Ile Pro Glu Gly 
    290                 295                 300                 


Leu Pro Ile Val Val Xaa Val Xaa Leu Ala Leu Gly Val Met Arg Met 
305                 310                 315                 320 


Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro Ile Val Glu Xaa Leu 
                325                 330                 335     


Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Xaa Gly Xaa Leu Xaa Lys 
            340                 345                 350         


Asn Glu Met Xaa Val Xaa His Ile Phe Xaa Ser Asp Gly Leu His Ala 
        355                 360                 365             


Glu Val Xaa Gly Val Gly Tyr Asn Gln Phe Gly Glu Val Ile Val Asp 
    370                 375                 380                 


Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala Val Ser Arg Ile Val 
385                 390                 395                 400 


Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile Arg Asn Asn Xaa Leu 
                405                 410                 415     


Met Gly Lys Pro Xaa Glu Gly Ala Leu Ile Ala Leu Ala Met Lys Met 
            420                 425                 430         


Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg Lys Ala Glu Tyr Pro 
        435                 440                 445             


Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys Cys Val His Arg Xaa 
    450                 455                 460                 


Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys Gly Ala Tyr Glu Gln 
465                 470                 475                 480 


Val Ile Lys Tyr Cys Xaa Xaa Tyr Gln Ser Lys Gly Gln Xaa Leu Xaa 
                485                 490                 495     


Leu Xaa Gln Gln Gln Arg Asp Val Tyr Gln Gln Glu Lys Ala Arg Met 
            500                 505                 510         


Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala Ser Gly Pro Glu Leu 
        515                 520                 525             


Gly Gln Leu Xaa Phe Leu Gly Leu Val Gly Ile Ile Asp Pro Pro Arg 
    530                 535                 540                 


Xaa Gly Val Lys Glu Ala Val Xaa Xaa Leu Ile Ala Ser Gly Val Ser 
545                 550                 555                 560 


Ile Lys Met Ile Xaa Gly Asp Ser Gln Glu Xaa Ala Val Ala Ile Ala 
                565                 570                 575     


Ser Arg Leu Gly Leu Tyr Ser Lys Xaa Ser Gln Ser Val Ser Gly Glu 
            580                 585                 590         


Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser Gln Ile Val Pro Lys 
        595                 600                 605             


Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His Lys Met Lys Ile Ile 
    610                 615                 620                 


Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala Met Xaa Gly Asp Gly 
625                 630                 635                 640 


Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp Ile Gly Val Ala Met 
                645                 650                 655     


Gly Gln Xaa Gly Xaa Asp Val Cys Lys Glu Ala Ala Asp Met Ile Leu 
            660                 665                 670         


Val Asp Asp Asp Phe Gln Xaa Ile Met Ser Ala Ile Glu Glu Gly Lys 
        675                 680                 685             


Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg Phe Gln Leu Ser Xaa 
    690                 695                 700                 


Ser Ile Ala Ala Leu Xaa Leu Ile Ser Leu Ala Xaa Leu Met Asn Phe 
705                 710                 715                 720 


Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp Ile Asn Ile Ile Met 
                725                 730                 735     


Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu Pro Val Asp Lys Asp 
            740                 745                 750         


Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp Ser Ile Leu Xaa Lys 
        755                 760                 765             


Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile Ile Ile Val Cys Gly 
    770                 775                 780                 


Xaa Leu Phe Val Phe Trp Arg Glu Leu Arg Asp Asn Val Ile Xaa Pro 
785                 790                 795                 800 


Arg Asp Xaa Xaa Met Xaa Phe Xaa Cys Phe Val Phe Phe Asp Met Phe 
                805                 810                 815     


Asn Ala Leu Ser Ser Arg Ser Gln Xaa Lys Ser Val Phe Glu Ile Gly 
            820                 825                 830         


Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val Leu Gly Ser Ile Met 
        835                 840                 845             


Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu Gln Lys Val Phe Gln 
    850                 855                 860                 


Xaa Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe Leu Leu Gly Leu Xaa 
865                 870                 875                 880 


Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys Lys Val Glu Arg Ser 
                885                 890                 895     


Arg Glu Lys Ile Gln Lys His Val Ser Ser Xaa Ser Ser Ser Phe Leu 
            900                 905                 910         


Glu Val Trp Leu Trp Glu Arg Ser Gly Gln Gln Leu Val Glu Ile His 
        915                 920                 925             


Pro His Leu Glu Xaa Gly Leu Pro Leu Xaa Glu Asp Val Ser Cys Val 
    930                 935                 940                 


<210> 3543
<211> 82
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<400> 3543
Met Ile Pro Val Leu Xaa Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
1               5                   10                  15      


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
            20                  25                  30          


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
        35                  40                  45              


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
    50                  55                  60                  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
65                  70                  75                  80  


Met His 
        


<210> 3544
<211> 903
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<400> 3544
Met Ile Pro Val Leu Xaa Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
1               5                   10                  15      


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
            20                  25                  30          


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
        35                  40                  45              


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
    50                  55                  60                  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
65                  70                  75                  80  


Met His Gln Phe Asp Asp Ala Val Ser Ile Xaa Val Ala Ile Leu Ile 
                85                  90                  95      


Val Val Xaa Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
            100                 105                 110         


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
        115                 120                 125             


Gly Lys Leu Glu His Xaa Leu Ala Arg Asp Leu Val Pro Gly Asp Xaa 
    130                 135                 140                 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
145                 150                 155                 160 


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Xaa Gly Glu Xaa 
                165                 170                 175     


Xaa Pro Cys Ser Lys Val Xaa Ala Pro Gln Pro Ala Ala Xaa Asn Gly 
            180                 185                 190         


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Xaa Leu Val Arg 
        195                 200                 205             


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Xaa Gly Glu Asn Ser Glu 
    210                 215                 220                 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Xaa 
225                 230                 235                 240 


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
                245                 250                 255     


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
            260                 265                 270         


Lys Asp Ile Leu Glu Met Phe Xaa Ile Ser Val Ser Leu Ala Val Ala 
        275                 280                 285             


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Xaa Val Xaa Leu Ala Leu 
    290                 295                 300                 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
305                 310                 315                 320 


Ile Val Glu Xaa Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Xaa 
                325                 330                 335     


Gly Xaa Leu Xaa Lys Asn Glu Met Xaa Val Xaa His Ile Phe Xaa Ser 
            340                 345                 350         


Asp Gly Leu His Ala Glu Val Xaa Gly Val Gly Tyr Asn Gln Phe Gly 
        355                 360                 365             


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
    370                 375                 380                 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
385                 390                 395                 400 


Arg Asn Asn Xaa Leu Met Gly Lys Pro Xaa Glu Gly Ala Leu Ile Ala 
                405                 410                 415     


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
            420                 425                 430         


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
        435                 440                 445             


Cys Val His Arg Xaa Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
    450                 455                 460                 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Xaa Xaa Tyr Gln Ser Lys 
465                 470                 475                 480 


Gly Gln Xaa Leu Xaa Leu Xaa Gln Gln Gln Arg Asp Val Tyr Gln Gln 
                485                 490                 495     


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
            500                 505                 510         


Ser Gly Pro Glu Leu Gly Gln Leu Xaa Phe Leu Gly Leu Val Gly Ile 
        515                 520                 525             


Ile Asp Pro Pro Arg Xaa Gly Val Lys Glu Ala Val Xaa Xaa Leu Ile 
    530                 535                 540                 


Ala Ser Gly Val Ser Ile Lys Met Ile Xaa Gly Asp Ser Gln Glu Xaa 
545                 550                 555                 560 


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Xaa Ser Gln 
                565                 570                 575     


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
            580                 585                 590         


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
        595                 600                 605             


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
    610                 615                 620                 


Met Xaa Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
625                 630                 635                 640 


Ile Gly Val Ala Met Gly Gln Xaa Gly Xaa Asp Val Cys Lys Glu Ala 
                645                 650                 655     


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Xaa Ile Met Ser Ala 
            660                 665                 670         


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
        675                 680                 685             


Phe Gln Leu Ser Xaa Ser Ile Ala Ala Leu Xaa Leu Ile Ser Leu Ala 
    690                 695                 700                 


Xaa Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
705                 710                 715                 720 


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
                725                 730                 735     


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
            740                 745                 750         


Ser Ile Leu Xaa Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
        755                 760                 765             


Ile Ile Val Cys Gly Xaa Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
    770                 775                 780                 


Asn Val Ile Xaa Pro Arg Asp Xaa Xaa Met Xaa Phe Xaa Cys Phe Val 
785                 790                 795                 800 


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Xaa Lys Ser 
                805                 810                 815     


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
            820                 825                 830         


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
        835                 840                 845             


Gln Lys Val Phe Gln Xaa Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
    850                 855                 860                 


Leu Leu Gly Leu Xaa Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
865                 870                 875                 880 


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Xaa 
                885                 890                 895     


Ser Ser Ser Phe Leu Glu Val 
            900             


<210> 3545
<211> 923
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<400> 3545
Met Ile Pro Val Leu Xaa Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
1               5                   10                  15      


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
            20                  25                  30          


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
        35                  40                  45              


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
    50                  55                  60                  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
65                  70                  75                  80  


Met His Gln Phe Asp Asp Ala Val Ser Ile Xaa Val Ala Ile Leu Ile 
                85                  90                  95      


Val Val Xaa Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
            100                 105                 110         


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
        115                 120                 125             


Gly Lys Leu Glu His Xaa Leu Ala Arg Asp Leu Val Pro Gly Asp Xaa 
    130                 135                 140                 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
145                 150                 155                 160 


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Xaa Gly Glu Xaa 
                165                 170                 175     


Xaa Pro Cys Ser Lys Val Xaa Ala Pro Gln Pro Ala Ala Xaa Asn Gly 
            180                 185                 190         


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Xaa Leu Val Arg 
        195                 200                 205             


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Xaa Gly Glu Asn Ser Glu 
    210                 215                 220                 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Xaa 
225                 230                 235                 240 


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
                245                 250                 255     


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
            260                 265                 270         


Lys Asp Ile Leu Glu Met Phe Xaa Ile Ser Val Ser Leu Ala Val Ala 
        275                 280                 285             


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Xaa Val Xaa Leu Ala Leu 
    290                 295                 300                 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
305                 310                 315                 320 


Ile Val Glu Xaa Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Xaa 
                325                 330                 335     


Gly Xaa Leu Xaa Lys Asn Glu Met Xaa Val Xaa His Ile Phe Xaa Ser 
            340                 345                 350         


Asp Gly Leu His Ala Glu Val Xaa Gly Val Gly Tyr Asn Gln Phe Gly 
        355                 360                 365             


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
    370                 375                 380                 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
385                 390                 395                 400 


Arg Asn Asn Xaa Leu Met Gly Lys Pro Xaa Glu Gly Ala Leu Ile Ala 
                405                 410                 415     


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
            420                 425                 430         


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
        435                 440                 445             


Cys Val His Arg Xaa Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
    450                 455                 460                 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Xaa Xaa Tyr Gln Ser Lys 
465                 470                 475                 480 


Gly Gln Xaa Leu Xaa Leu Xaa Gln Gln Gln Arg Asp Val Tyr Gln Gln 
                485                 490                 495     


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
            500                 505                 510         


Ser Gly Pro Glu Leu Gly Gln Leu Xaa Phe Leu Gly Leu Val Gly Ile 
        515                 520                 525             


Ile Asp Pro Pro Arg Xaa Gly Val Lys Glu Ala Val Xaa Xaa Leu Ile 
    530                 535                 540                 


Ala Ser Gly Val Ser Ile Lys Met Ile Xaa Gly Asp Ser Gln Glu Xaa 
545                 550                 555                 560 


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Xaa Ser Gln 
                565                 570                 575     


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
            580                 585                 590         


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
        595                 600                 605             


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
    610                 615                 620                 


Met Xaa Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
625                 630                 635                 640 


Ile Gly Val Ala Met Gly Gln Xaa Gly Xaa Asp Val Cys Lys Glu Ala 
                645                 650                 655     


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Xaa Ile Met Ser Ala 
            660                 665                 670         


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
        675                 680                 685             


Phe Gln Leu Ser Xaa Ser Ile Ala Ala Leu Xaa Leu Ile Ser Leu Ala 
    690                 695                 700                 


Xaa Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
705                 710                 715                 720 


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
                725                 730                 735     


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
            740                 745                 750         


Ser Ile Leu Xaa Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
        755                 760                 765             


Ile Ile Val Cys Gly Xaa Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
    770                 775                 780                 


Asn Val Ile Xaa Pro Arg Asp Xaa Xaa Met Xaa Phe Xaa Cys Phe Val 
785                 790                 795                 800 


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Xaa Lys Ser 
                805                 810                 815     


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
            820                 825                 830         


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
        835                 840                 845             


Gln Lys Val Phe Gln Xaa Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
    850                 855                 860                 


Leu Leu Gly Leu Xaa Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
865                 870                 875                 880 


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Trp Leu Trp 
                885                 890                 895     


Glu Arg Ser Gly Gln Gln Leu Val Glu Ile His Pro His Leu Glu Xaa 
            900                 905                 910         


Gly Leu Pro Leu Xaa Glu Asp Val Ser Cys Val 
        915                 920             


<210> 3546
<211> 102
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<400> 3546
Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Xaa 
1               5                   10                  15      


Met Ile Pro Val Leu Xaa Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp 
            100         


<210> 3547
<211> 120
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 3547
Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Xaa 
1               5                   10                  15      


Met Ile Pro Val Leu Xaa Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Xaa Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Xaa Val Ala Phe Val Gln 
        115                 120 


<210> 3548
<211> 888
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<400> 3548
Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Xaa 
1               5                   10                  15      


Met Ile Pro Val Leu Xaa Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Xaa Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Xaa Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Xaa Leu Ala Arg Asp Leu Val Pro Gly Asp Xaa 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Xaa Gly Glu Xaa 
            180                 185                 190         


Xaa Pro Cys Ser Lys Val Xaa Ala Pro Gln Pro Ala Ala Xaa Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Xaa Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Xaa Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Xaa 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Xaa Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Xaa Val Xaa Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Xaa Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Xaa 
            340                 345                 350         


Gly Xaa Leu Xaa Lys Asn Glu Met Xaa Val Xaa His Ile Phe Xaa Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Xaa Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Xaa Leu Met Gly Lys Pro Xaa Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Xaa Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Xaa Xaa Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Xaa Leu Xaa Leu Xaa Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Xaa Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Xaa Gly Val Lys Glu Ala Val Xaa Xaa Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Xaa Gly Asp Ser Gln Glu Xaa 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Xaa Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Xaa Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Xaa Gly Xaa Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Xaa Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Xaa Ser Ile Ala Ala Leu Xaa Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Xaa Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Xaa Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Xaa Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Xaa Pro Arg Asp Xaa Xaa Met Xaa Phe Xaa Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Xaa Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Xaa Glu Ser Leu Ser Ile Leu Gly Leu Ala Leu 
865                 870                 875                 880 


Gly Glu Glu Trp Xaa Ala Ala Gly 
                885             


<210> 3549
<211> 919
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<400> 3549
Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Xaa 
1               5                   10                  15      


Met Ile Pro Val Leu Xaa Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Xaa Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Xaa Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Xaa Leu Ala Arg Asp Leu Val Pro Gly Asp Xaa 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Xaa Gly Glu Xaa 
            180                 185                 190         


Xaa Pro Cys Ser Lys Val Xaa Ala Pro Gln Pro Ala Ala Xaa Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Xaa Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Xaa Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Xaa 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Xaa Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Xaa Val Xaa Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Xaa Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Xaa 
            340                 345                 350         


Gly Xaa Leu Xaa Lys Asn Glu Met Xaa Val Xaa His Ile Phe Xaa Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Xaa Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Xaa Leu Met Gly Lys Pro Xaa Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Xaa Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Xaa Xaa Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Xaa Leu Xaa Leu Xaa Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Xaa Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Xaa Gly Val Lys Glu Ala Val Xaa Xaa Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Xaa Gly Asp Ser Gln Glu Xaa 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Xaa Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Xaa Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Xaa Gly Xaa Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Xaa Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Xaa Ser Ile Ala Ala Leu Xaa Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Xaa Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Xaa Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Xaa Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Xaa Pro Arg Asp Xaa Xaa Met Xaa Phe Xaa Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Xaa Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Xaa Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Xaa Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Xaa 
            900                 905                 910         


Ser Ser Ser Phe Leu Glu Val 
        915                 


<210> 3550
<211> 939
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<400> 3550
Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Xaa 
1               5                   10                  15      


Met Ile Pro Val Leu Xaa Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Xaa Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Xaa Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Xaa Leu Ala Arg Asp Leu Val Pro Gly Asp Xaa 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Xaa Gly Glu Xaa 
            180                 185                 190         


Xaa Pro Cys Ser Lys Val Xaa Ala Pro Gln Pro Ala Ala Xaa Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Xaa Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Xaa Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Xaa 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Xaa Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Xaa Val Xaa Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Xaa Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Xaa 
            340                 345                 350         


Gly Xaa Leu Xaa Lys Asn Glu Met Xaa Val Xaa His Ile Phe Xaa Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Xaa Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Xaa Leu Met Gly Lys Pro Xaa Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Xaa Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Xaa Xaa Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Xaa Leu Xaa Leu Xaa Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Xaa Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Xaa Gly Val Lys Glu Ala Val Xaa Xaa Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Xaa Gly Asp Ser Gln Glu Xaa 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Xaa Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Xaa Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Xaa Gly Xaa Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Xaa Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Xaa Ser Ile Ala Ala Leu Xaa Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Xaa Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Xaa Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Xaa Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Xaa Pro Arg Asp Xaa Xaa Met Xaa Phe Xaa Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Xaa Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Xaa Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Xaa Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Trp Leu Trp 
            900                 905                 910         


Glu Arg Ser Gly Gln Gln Leu Val Glu Ile His Pro His Leu Glu Xaa 
        915                 920                 925             


Gly Leu Pro Leu Xaa Glu Asp Val Ser Cys Val 
    930                 935                 


<210> 3551
<211> 949
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<400> 3551
Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Xaa 
1               5                   10                  15      


Met Ile Pro Val Leu Xaa Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Xaa Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Xaa Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Xaa Leu Ala Arg Asp Leu Val Pro Gly Asp Xaa 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Xaa Gly Glu Xaa 
            180                 185                 190         


Xaa Pro Cys Ser Lys Val Xaa Ala Pro Gln Pro Ala Ala Xaa Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Xaa Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Xaa Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Xaa 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Xaa Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Xaa Val Xaa Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Xaa Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Xaa 
            340                 345                 350         


Gly Xaa Leu Xaa Lys Asn Glu Met Xaa Val Xaa His Ile Phe Xaa Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Xaa Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Xaa Leu Met Gly Lys Pro Xaa Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Xaa Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Xaa Xaa Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Xaa Leu Xaa Leu Xaa Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Xaa Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Xaa Gly Val Lys Glu Ala Val Xaa Xaa Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Xaa Gly Asp Ser Gln Glu Xaa 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Xaa Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Xaa Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Xaa Gly Xaa Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Xaa Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Xaa Ser Ile Ala Ala Leu Xaa Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Xaa Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Xaa Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Xaa Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Xaa Pro Arg Asp Xaa Xaa Met Xaa Phe Xaa Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Xaa Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Xaa Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Xaa Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Xaa 
            900                 905                 910         


Ser Ser Ser Phe Leu Glu Val Trp Leu Trp Glu Arg Ser Gly Gln Gln 
        915                 920                 925             


Leu Val Glu Ile His Pro His Leu Glu Xaa Gly Leu Pro Leu Xaa Glu 
    930                 935                 940                 


Asp Val Ser Cys Val 
945                 


<210> 3552
<211> 215
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<400> 3552
Val Xaa Val Xaa Leu Ala Leu Gly Val Met Arg Met Val Lys Lys Arg 
1               5                   10                  15      


Ala Ile Val Lys Lys Leu Pro Ile Val Glu Xaa Leu Gly Cys Cys Asn 
            20                  25                  30          


Val Ile Cys Ser Asp Lys Xaa Gly Xaa Leu Xaa Lys Asn Glu Met Xaa 
        35                  40                  45              


Val Xaa His Ile Phe Xaa Ser Asp Gly Leu His Ala Glu Val Xaa Gly 
    50                  55                  60                  


Val Gly Tyr Asn Gln Phe Gly Glu Val Ile Val Asp Gly Asp Val Val 
65                  70                  75                  80  


His Gly Phe Tyr Asn Pro Ala Val Ser Arg Ile Val Glu Ala Gly Cys 
                85                  90                  95      


Val Cys Asn Asp Ala Val Ile Arg Asn Asn Xaa Leu Met Gly Lys Pro 
            100                 105                 110         


Xaa Glu Gly Ala Leu Ile Ala Leu Ala Met Lys Met Gly Leu Asp Gly 
        115                 120                 125             


Leu Gln Gln Asp Tyr Ile Arg Lys Ala Glu Tyr Pro Phe Ser Ser Glu 
    130                 135                 140                 


Gln Lys Trp Met Ala Val Lys Cys Val His Arg Xaa Gln Gln Asp Arg 
145                 150                 155                 160 


Pro Glu Ile Cys Phe Met Lys Gly Ala Tyr Glu Gln Val Ile Lys Tyr 
                165                 170                 175     


Cys Xaa Xaa Tyr Gln Ser Lys Gly Gln Xaa Leu Xaa Leu Xaa Gln Gln 
            180                 185                 190         


Gln Arg Asp Val Tyr Gln Gln Glu Lys Ala Arg Met Gly Ser Ala Gly 
        195                 200                 205             


Leu Arg Val Tyr Leu Val Phe 
    210                 215 


<210> 3553
<211> 314
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<400> 3553
Xaa Glu Gly Ala Leu Ile Ala Leu Ala Met Lys Met Gly Leu Asp Gly 
1               5                   10                  15      


Leu Gln Gln Asp Tyr Ile Arg Lys Ala Glu Tyr Pro Phe Ser Ser Glu 
            20                  25                  30          


Gln Lys Trp Met Ala Val Lys Cys Val His Arg Xaa Gln Gln Asp Arg 
        35                  40                  45              


Pro Glu Ile Cys Phe Met Lys Gly Ala Tyr Glu Gln Val Ile Lys Tyr 
    50                  55                  60                  


Cys Xaa Xaa Tyr Gln Ser Lys Gly Gln Xaa Leu Xaa Leu Xaa Gln Gln 
65                  70                  75                  80  


Gln Arg Asp Val Tyr Gln Gln Glu Lys Ala Arg Met Gly Ser Ala Gly 
                85                  90                  95      


Leu Arg Ala Ser Arg Leu Gly Leu Tyr Ser Lys Xaa Ser Gln Ser Val 
            100                 105                 110         


Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser Gln Ile 
        115                 120                 125             


Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His Lys Met 
    130                 135                 140                 


Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala Met Xaa 
145                 150                 155                 160 


Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp Ile Gly 
                165                 170                 175     


Val Ala Met Gly Gln Xaa Gly Xaa Asp Val Cys Lys Glu Ala Ala Asp 
            180                 185                 190         


Met Ile Leu Val Asp Asp Asp Phe Gln Xaa Ile Met Ser Ala Ile Glu 
        195                 200                 205             


Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg Phe Gln 
    210                 215                 220                 


Leu Ser Xaa Ser Ile Ala Ala Leu Xaa Leu Ile Ser Leu Ala Xaa Leu 
225                 230                 235                 240 


Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp Ile Asn 
                245                 250                 255     


Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu Pro Val 
            260                 265                 270         


Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp Ser Ile 
        275                 280                 285             


Leu Xaa Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile Ile Ile 
    290                 295                 300                 


Val Cys Gly Xaa Leu Phe Val Phe Trp Arg 
305                 310                 


<210> 3554
<211> 903
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<400> 3554
Xaa Lys Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu 
1               5                   10                  15      


Phe Asp Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln 
            20                  25                  30          


Phe Lys Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser 
        35                  40                  45              


Val Leu Met His Gln Phe Asp Asp Ala Val Ser Ile Xaa Val Ala Ile 
    50                  55                  60                  


Leu Ile Val Val Xaa Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys 
65                  70                  75                  80  


Ser Leu Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val 
                85                  90                  95      


Arg Glu Gly Lys Leu Glu His Xaa Leu Ala Arg Asp Leu Val Pro Gly 
            100                 105                 110         


Asp Xaa Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg 
        115                 120                 125             


Leu Phe Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Xaa Gly 
    130                 135                 140                 


Glu Xaa Xaa Pro Cys Ser Lys Val Xaa Ala Pro Gln Pro Ala Ala Xaa 
145                 150                 155                 160 


Asn Gly Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Xaa Leu 
                165                 170                 175     


Val Arg Cys Gly Lys Ala Lys Gly Val Val Ile Gly Xaa Gly Glu Asn 
            180                 185                 190         


Ser Glu Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro 
        195                 200                 205             


Lys Xaa Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser 
    210                 215                 220                 


Phe Tyr Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu 
225                 230                 235                 240 


Leu Gly Lys Asp Ile Leu Glu Met Phe Xaa Ile Ser Val Ser Leu Ala 
                245                 250                 255     


Val Ala Ala Ile Pro Glu Gly Leu Pro Ile Val Val Xaa Val Xaa Leu 
            260                 265                 270         


Ala Leu Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys 
        275                 280                 285             


Leu Pro Ile Val Glu Xaa Leu Gly Cys Cys Asn Val Ile Cys Ser Asp 
    290                 295                 300                 


Lys Xaa Gly Xaa Leu Xaa Lys Asn Glu Met Xaa Val Xaa His Ile Phe 
305                 310                 315                 320 


Xaa Ser Asp Gly Leu His Ala Glu Val Xaa Gly Val Gly Tyr Asn Gln 
                325                 330                 335     


Phe Gly Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn 
            340                 345                 350         


Pro Ala Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala 
        355                 360                 365             


Val Ile Arg Asn Asn Xaa Leu Met Gly Lys Pro Xaa Glu Gly Ala Leu 
    370                 375                 380                 


Ile Ala Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr 
385                 390                 395                 400 


Ile Arg Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala 
                405                 410                 415     


Val Lys Cys Val His Arg Xaa Gln Gln Asp Arg Pro Glu Ile Cys Phe 
            420                 425                 430         


Met Lys Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Xaa Xaa Tyr Gln 
        435                 440                 445             


Ser Lys Gly Gln Xaa Leu Xaa Leu Xaa Gln Gln Gln Arg Asp Val Tyr 
    450                 455                 460                 


Gln Gln Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala 
465                 470                 475                 480 


Leu Ala Ser Gly Pro Glu Leu Gly Gln Leu Xaa Phe Leu Gly Leu Val 
                485                 490                 495     


Gly Ile Ile Asp Pro Pro Arg Xaa Gly Val Lys Glu Ala Val Xaa Xaa 
            500                 505                 510         


Leu Ile Ala Ser Gly Val Ser Ile Lys Met Ile Xaa Gly Asp Ser Gln 
        515                 520                 525             


Glu Xaa Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Xaa 
    530                 535                 540                 


Ser Gln Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln 
545                 550                 555                 560 


Leu Ser Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro 
                565                 570                 575     


Arg His Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val 
            580                 585                 590         


Val Ala Met Xaa Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala 
        595                 600                 605             


Ala Asp Ile Gly Val Ala Met Gly Gln Xaa Gly Xaa Asp Val Cys Lys 
    610                 615                 620                 


Glu Ala Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Xaa Ile Met 
625                 630                 635                 640 


Ser Ala Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe 
                645                 650                 655     


Val Arg Phe Gln Leu Ser Xaa Ser Ile Ala Ala Leu Xaa Leu Ile Ser 
            660                 665                 670         


Leu Ala Xaa Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile 
        675                 680                 685             


Leu Trp Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly 
    690                 695                 700                 


Val Glu Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp 
705                 710                 715                 720 


Lys Asp Ser Ile Leu Xaa Lys Asn Leu Ile Leu Lys Ile Leu Val Ser 
                725                 730                 735     


Ser Ile Ile Ile Val Cys Gly Xaa Leu Phe Val Phe Trp Arg Glu Leu 
            740                 745                 750         


Arg Asp Asn Val Ile Xaa Pro Arg Asp Xaa Xaa Met Xaa Phe Xaa Cys 
        755                 760                 765             


Phe Val Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Xaa 
    770                 775                 780                 


Lys Ser Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr 
785                 790                 795                 800 


Ala Val Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro 
                805                 810                 815     


Pro Leu Gln Lys Val Phe Gln Xaa Glu Ser Leu Ser Ile Leu Asp Leu 
            820                 825                 830         


Leu Phe Leu Leu Gly Leu Xaa Ser Ser Val Cys Ile Val Ala Glu Ile 
        835                 840                 845             


Ile Lys Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser 
    850                 855                 860                 


Ser Xaa Ser Ser Ser Phe Leu Glu Val Trp Leu Trp Glu Arg Ser Gly 
865                 870                 875                 880 


Gln Gln Leu Val Glu Ile His Pro His Leu Glu Xaa Gly Leu Pro Leu 
                885                 890                 895     


Xaa Glu Asp Val Ser Cys Val 
            900             


<210> 3555
<211> 44
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<400> 3555
Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg 
1               5                   10                  15      


Arg Ala Gly Leu Asn Xaa Phe Ala Leu Gly Leu Gln Lys Cys Phe Gly 
            20                  25                  30          


Phe Ile Phe His Cys Cys Lys Glu Leu Pro Cys Leu 
        35                  40                  


<210> 3556
<211> 199
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<400> 3556
Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg 
1               5                   10                  15      


Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala 
            20                  25                  30          


Ala Arg Asn Phe His Ala Ser Asn Xaa His Leu Gln Lys Xaa Ala Ile 
        35                  40                  45              


Val Asp Val Pro Val Gly Glu Glu Leu Leu Gly Arg Val Val Asp Ala 
    50                  55                  60                  


Leu Gly Asn Ala Ile Asp Gly Lys Gly Pro Ile Gly Ser Lys Xaa Arg 
65                  70                  75                  80  


Arg Arg Val Gly Leu Lys Ala Pro Gly Ile Ile Pro Arg Ile Ser Val 
                85                  90                  95      


Arg Glu Pro Met Gln Xaa Gly Ile Lys Ala Val Asp Ser Leu Val Pro 
            100                 105                 110         


Ile Gly Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp Arg Gln Xaa Gly 
        115                 120                 125             


Lys Xaa Ser Ile Ala Ile Asp Xaa Ile Ile Asn Gln Lys Arg Phe Asn 
    130                 135                 140                 


Asp Gly Ser Asp Glu Lys Lys Lys Leu Tyr Cys Ile Tyr Val Ala Ile 
145                 150                 155                 160 


Gly Gln Lys Arg Ser Xaa Val Ala Gln Leu Val Lys Arg Leu Xaa Asp 
                165                 170                 175     


Ala Asp Ala Met Lys Tyr Xaa Ile Val Val Ser Ala Xaa Ala Ser Asp 
            180                 185                 190         


Ala Ala Pro Leu Gln Tyr Leu 
        195                 


<210> 3557
<211> 58
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<400> 3557
Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg 
1               5                   10                  15      


Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala 
            20                  25                  30          


Ala Arg Asn Phe His Ala Ser Asn Xaa His Leu Gln Lys Xaa Gly Lys 
        35                  40                  45              


Leu Leu Phe Leu Ser Leu Arg Arg Xaa Tyr 
    50                  55              


<210> 3558
<211> 531
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<400> 3558
Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg 
1               5                   10                  15      


Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala 
            20                  25                  30          


Ala Arg Asn Phe His Ala Ser Asn Xaa His Leu Gln Lys Xaa Gly Xaa 
        35                  40                  45              


Ala Glu Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Xaa 
    50                  55                  60                  


Ser Val Asp Leu Glu Glu Xaa Gly Arg Val Leu Ser Ile Gly Asp Gly 
65                  70                  75                  80  


Ile Ala Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val 
                85                  90                  95      


Glu Phe Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp 
            100                 105                 110         


Asn Val Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly 
        115                 120                 125             


Asp Ile Val Lys Arg Xaa Gly Ala Ile Val Asp Gly Pro Ile Gly Ser 
    130                 135                 140                 


Lys Xaa Arg Arg Arg Val Gly Leu Lys Ala Pro Gly Ile Ile Pro Arg 
145                 150                 155                 160 


Ile Ser Val Arg Glu Pro Met Gln Xaa Gly Ile Lys Ala Val Asp Ser 
                165                 170                 175     


Leu Val Pro Ile Gly Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp Arg 
            180                 185                 190         


Gln Xaa Gly Lys Xaa Ser Ile Ala Ile Asp Xaa Ile Ile Asn Gln Lys 
        195                 200                 205             


Arg Phe Asn Asp Gly Ser Asp Glu Lys Lys Lys Leu Tyr Cys Ile Tyr 
    210                 215                 220                 


Val Ala Ile Gly Gln Lys Arg Ser Xaa Val Ala Gln Leu Val Lys Arg 
225                 230                 235                 240 


Leu Xaa Asp Ala Asp Ala Met Lys Tyr Xaa Ile Val Val Ser Ala Xaa 
                245                 250                 255     


Ala Ser Asp Ala Ala Pro Leu Gln Tyr Leu Ala Pro Tyr Ser Gly Cys 
            260                 265                 270         


Ser Met Gly Glu Tyr Phe Arg Asp Asn Gly Lys His Ala Leu Ile Ile 
        275                 280                 285             


Tyr Asp Asp Leu Ser Lys Gln Ala Val Ala Tyr Arg Gln Met Ser Leu 
    290                 295                 300                 


Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala Tyr Pro Gly Asp Val Phe 
305                 310                 315                 320 


Tyr Leu His Ser Arg Leu Leu Glu Arg Ala Ala Lys Met Asn Asp Ala 
                325                 330                 335     


Phe Gly Gly Gly Ser Leu Xaa Ala Leu Pro Val Ile Glu Xaa Gln Ala 
            340                 345                 350         


Gly Asp Val Ser Ala Tyr Ile Pro Xaa Asn Val Ile Ser Ile Xaa Asp 
        355                 360                 365             


Gly Gln Ile Phe Leu Glu Xaa Glu Leu Phe Tyr Lys Gly Ile Arg Pro 
    370                 375                 380                 


Ala Ile Asn Val Gly Leu Ser Val Ser Arg Val Gly Ser Ala Ala Gln 
385                 390                 395                 400 


Xaa Arg Ala Met Lys Gln Val Ala Gly Xaa Met Lys Leu Glu Leu Ala 
                405                 410                 415     


Gln Tyr Arg Glu Val Ala Ala Phe Ala Gln Phe Gly Ser Asp Leu Asp 
            420                 425                 430         


Ala Ala Xaa Gln Gln Leu Leu Ser Arg Gly Val Arg Leu Xaa Glu Leu 
        435                 440                 445             


Leu Lys Gln Gly Gln Tyr Ser Pro Met Ala Ile Glu Glu Gln Val Ala 
    450                 455                 460                 


Val Ile Tyr Ala Gly Val Arg Gly Tyr Leu Asp Lys Leu Glu Pro Ser 
465                 470                 475                 480 


Lys Ile Xaa Lys Phe Glu Asn Ala Phe Leu Ser His Val Val Ser Gln 
                485                 490                 495     


His Gln Ala Leu Leu Gly Xaa Ile Arg Ala Asp Gly Lys Ile Ser Glu 
            500                 505                 510         


Gln Ser Asp Ala Lys Leu Lys Glu Ile Val Xaa Asn Phe Leu Ala Gly 
        515                 520                 525             


Phe Glu Ala 
    530     


<210> 3559
<211> 205
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<400> 3559
Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg 
1               5                   10                  15      


Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala 
            20                  25                  30          


Ala Arg Asn Phe His Ala Ser Asn Xaa His Leu Gln Lys Xaa Gly Xaa 
        35                  40                  45              


Ala Glu Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Xaa 
    50                  55                  60                  


Ser Val Asp Leu Glu Glu Xaa Gly Arg Val Leu Ser Ile Gly Asp Gly 
65                  70                  75                  80  


Ile Ala Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val 
                85                  90                  95      


Glu Phe Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp 
            100                 105                 110         


Asn Val Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly 
        115                 120                 125             


Asp Ile Val Lys Arg Xaa Gly Ala Ile Val Asp Val Pro Val Gly Glu 
    130                 135                 140                 


Glu Leu Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly 
145                 150                 155                 160 


Lys Gly Pro Ile Gly Ser Lys Xaa Arg Arg Arg Val Gly Leu Lys Ala 
                165                 170                 175     


Pro Gly Ile Ile Pro Arg Ile Ser Val Arg Glu Pro Met Gln Xaa Gly 
            180                 185                 190         


Ile Lys Ala Val Asp Ser Leu Val Pro Ile Gly Arg Gly 
        195                 200                 205 


<210> 3560
<211> 553
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<400> 3560
Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg 
1               5                   10                  15      


Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala 
            20                  25                  30          


Ala Arg Asn Phe His Ala Ser Asn Xaa His Leu Gln Lys Xaa Gly Xaa 
        35                  40                  45              


Ala Glu Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Xaa 
    50                  55                  60                  


Ser Val Asp Leu Glu Glu Xaa Gly Arg Val Leu Ser Ile Gly Asp Gly 
65                  70                  75                  80  


Ile Ala Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val 
                85                  90                  95      


Glu Phe Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp 
            100                 105                 110         


Asn Val Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly 
        115                 120                 125             


Asp Ile Val Lys Arg Xaa Gly Ala Ile Val Asp Val Pro Val Gly Glu 
    130                 135                 140                 


Glu Leu Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly 
145                 150                 155                 160 


Lys Gly Pro Ile Gly Ser Lys Xaa Arg Arg Arg Val Gly Leu Lys Ala 
                165                 170                 175     


Pro Gly Ile Ile Pro Arg Ile Ser Val Arg Glu Pro Met Gln Xaa Gly 
            180                 185                 190         


Ile Lys Ala Val Asp Ser Leu Val Pro Ile Gly Arg Gly Gln Arg Glu 
        195                 200                 205             


Leu Ile Ile Gly Asp Arg Gln Xaa Gly Lys Xaa Ser Ile Ala Ile Asp 
    210                 215                 220                 


Xaa Ile Ile Asn Gln Lys Arg Phe Asn Asp Gly Ser Asp Glu Lys Lys 
225                 230                 235                 240 


Lys Leu Tyr Cys Ile Tyr Val Ala Ile Gly Gln Lys Arg Ser Xaa Val 
                245                 250                 255     


Ala Gln Leu Val Lys Arg Leu Xaa Asp Ala Asp Ala Met Lys Tyr Xaa 
            260                 265                 270         


Ile Val Val Ser Ala Xaa Ala Ser Asp Ala Ala Pro Leu Gln Tyr Leu 
        275                 280                 285             


Ala Pro Tyr Ser Gly Cys Ser Met Gly Glu Tyr Phe Arg Asp Asn Gly 
    290                 295                 300                 


Lys His Ala Leu Ile Ile Tyr Asp Asp Leu Ser Lys Gln Ala Val Ala 
305                 310                 315                 320 


Tyr Arg Gln Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala 
                325                 330                 335     


Tyr Pro Gly Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala 
            340                 345                 350         


Ala Lys Met Asn Asp Ala Phe Gly Gly Gly Ser Leu Xaa Ala Leu Pro 
        355                 360                 365             


Val Ile Glu Xaa Gln Ala Gly Asp Val Ser Ala Tyr Ile Pro Xaa Asn 
    370                 375                 380                 


Val Ile Ser Ile Xaa Asp Gly Gln Ile Phe Leu Glu Xaa Glu Leu Phe 
385                 390                 395                 400 


Tyr Lys Gly Ile Arg Pro Ala Ile Asn Val Gly Leu Ser Val Ser Arg 
                405                 410                 415     


Val Gly Ser Ala Ala Gln Xaa Arg Ala Met Lys Gln Val Ala Gly Xaa 
            420                 425                 430         


Met Lys Leu Glu Leu Ala Gln Tyr Arg Glu Val Ala Ala Phe Ala Gln 
        435                 440                 445             


Phe Gly Ser Asp Leu Asp Ala Ala Xaa Gln Gln Leu Leu Ser Arg Gly 
    450                 455                 460                 


Val Arg Leu Xaa Glu Leu Leu Lys Gln Gly Gln Tyr Ser Pro Met Ala 
465                 470                 475                 480 


Ile Glu Glu Gln Val Ala Val Ile Tyr Ala Gly Val Arg Gly Tyr Leu 
                485                 490                 495     


Asp Lys Leu Glu Pro Ser Lys Ile Xaa Lys Phe Glu Asn Ala Phe Leu 
            500                 505                 510         


Ser His Val Val Ser Gln His Gln Ala Leu Leu Gly Xaa Ile Arg Ala 
        515                 520                 525             


Asp Gly Lys Ile Ser Glu Gln Ser Asp Ala Lys Leu Lys Glu Ile Val 
    530                 535                 540                 


Xaa Asn Phe Leu Ala Gly Phe Glu Ala 
545                 550             


<210> 3561
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<400> 3561
Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg 
1               5                   10                  15      


Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala 
            20                  25                  30          


Ala Arg Asn Phe His Ala Ser Asn Xaa His Leu Gln Lys Xaa Gly Xaa 
        35                  40                  45              


Ala Glu Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Xaa 
    50                  55                  60                  


Ser Val Asp Leu Glu Glu Xaa Gly Arg Val Leu Ser Trp 
65                  70                  75          


<210> 3562
<211> 90
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<400> 3562
Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg 
1               5                   10                  15      


Arg Ala Gly Leu Val Ser Xaa Glu Gly Arg His Asp Ala Gly Gly Arg 
            20                  25                  30          


Val Gly Leu Gln Gly Gly Gly Ala Pro Ala Arg Ala Leu Ser Ala Gly 
        35                  40                  45              


Gly Arg Gly Ala Val Ala Asn Ala Ala Ile Leu His Pro Trp Leu Leu 
    50                  55                  60                  


Arg Leu Asp Arg Ala Gly Asp Xaa Gly Ala Leu Leu Leu Val Xaa Cys 
65                  70                  75                  80  


Ala Glu Ala Glu Trp Tyr Arg Ala Asp Ser 
                85                  90  


<210> 3563
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<400> 3563
Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Xaa Ser Val 
1               5                   10                  15      


Asp Leu Glu Glu Xaa Gly Arg Val Leu Ser Ile Gly Asp Gly Ile Ala 
            20                  25                  30          


Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val Glu Phe 
        35                  40                  45              


Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp Asn Val 
    50                  55                  60                  


Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly Asp Ile 
65                  70                  75                  80  


Val Lys Arg Xaa Gly Ala Ile Val Asp Val Pro Val Gly Glu Glu Leu 
                85                  90                  95      


Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly Lys 
            100                 105                 110     


<210> 3564
<211> 145
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<400> 3564
Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Xaa Ser Val 
1               5                   10                  15      


Asp Leu Glu Glu Xaa Gly Arg Val Leu Ser Ile Gly Asp Gly Ile Ala 
            20                  25                  30          


Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val Glu Phe 
        35                  40                  45              


Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp Asn Val 
    50                  55                  60                  


Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly Asp Ile 
65                  70                  75                  80  


Val Lys Arg Xaa Gly Ala Ile Val Asp Val Pro Val Gly Glu Glu Leu 
                85                  90                  95      


Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly Lys Gly 
            100                 105                 110         


Pro Ile Gly Ser Lys Xaa Arg Arg Arg Val Gly Leu Lys Ala Pro Gly 
        115                 120                 125             


Ile Ile Pro Arg Ile Ser Val Arg Glu Pro Met Gln Xaa Gly Ile Lys 
    130                 135                 140                 


Ala 
145 


<210> 3565
<211> 207
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<400> 3565
Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Xaa Ser Val 
1               5                   10                  15      


Asp Leu Glu Glu Xaa Gly Arg Val Leu Ser Ile Gly Asp Gly Ile Ala 
            20                  25                  30          


Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val Glu Phe 
        35                  40                  45              


Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp Asn Val 
    50                  55                  60                  


Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly Asp Ile 
65                  70                  75                  80  


Val Lys Arg Xaa Gly Ala Ile Val Asp Val Pro Val Gly Glu Glu Leu 
                85                  90                  95      


Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly Lys Gly 
            100                 105                 110         


Pro Ile Gly Ser Lys Xaa Arg Arg Arg Val Gly Leu Lys Ala Pro Gly 
        115                 120                 125             


Ile Ile Pro Arg Ile Ser Val Arg Glu Pro Met Gln Xaa Gly Ile Lys 
    130                 135                 140                 


Ala Val Asp Ser Leu Val Pro Ile Gly Arg Gly Gln Arg Glu Leu Ile 
145                 150                 155                 160 


Ile Gly Asp Arg Gln Xaa Gly Lys Xaa Ser Ile Ala Ile Asp Xaa Ile 
                165                 170                 175     


Ile Asn Gln Lys Arg Phe Asn Asp Gly Ser Asp Glu Lys Lys Lys Leu 
            180                 185                 190         


Tyr Cys Ile Tyr Val Ala Ile Gly Gln Lys Arg Ser Xaa Val Ala 
        195                 200                 205         


<210> 3566
<211> 503
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<400> 3566
Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Xaa Ser Val 
1               5                   10                  15      


Asp Leu Glu Glu Xaa Gly Arg Val Leu Ser Ile Gly Asp Gly Ile Ala 
            20                  25                  30          


Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val Glu Phe 
        35                  40                  45              


Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp Asn Val 
    50                  55                  60                  


Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly Asp Ile 
65                  70                  75                  80  


Val Lys Arg Xaa Gly Ala Ile Val Asp Val Pro Val Gly Glu Glu Leu 
                85                  90                  95      


Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly Lys Gly 
            100                 105                 110         


Pro Ile Gly Ser Lys Xaa Arg Arg Arg Val Gly Leu Lys Ala Pro Gly 
        115                 120                 125             


Ile Ile Pro Arg Ile Ser Val Arg Glu Pro Met Gln Xaa Gly Ile Lys 
    130                 135                 140                 


Ala Val Asp Ser Leu Val Pro Ile Gly Arg Gly Gln Arg Glu Leu Ile 
145                 150                 155                 160 


Ile Gly Asp Arg Gln Xaa Gly Lys Xaa Ser Ile Ala Ile Asp Xaa Ile 
                165                 170                 175     


Ile Asn Gln Lys Arg Phe Asn Asp Gly Ser Asp Glu Lys Lys Lys Leu 
            180                 185                 190         


Tyr Cys Ile Tyr Val Ala Ile Gly Gln Lys Arg Ser Xaa Val Ala Gln 
        195                 200                 205             


Leu Val Lys Arg Leu Xaa Asp Ala Asp Ala Met Lys Tyr Xaa Ile Val 
    210                 215                 220                 


Val Ser Ala Xaa Ala Ser Asp Ala Ala Pro Leu Gln Tyr Leu Ala Pro 
225                 230                 235                 240 


Tyr Ser Gly Cys Ser Met Gly Glu Tyr Phe Arg Asp Asn Gly Lys His 
                245                 250                 255     


Ala Leu Ile Ile Tyr Asp Asp Leu Ser Lys Gln Ala Val Ala Tyr Arg 
            260                 265                 270         


Gln Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala Tyr Pro 
        275                 280                 285             


Gly Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala Ala Lys 
    290                 295                 300                 


Met Asn Asp Ala Phe Gly Gly Gly Ser Leu Xaa Ala Leu Pro Val Ile 
305                 310                 315                 320 


Glu Xaa Gln Ala Gly Asp Val Ser Ala Tyr Ile Pro Xaa Asn Val Ile 
                325                 330                 335     


Ser Ile Xaa Asp Gly Gln Ile Phe Leu Glu Xaa Glu Leu Phe Tyr Lys 
            340                 345                 350         


Gly Ile Arg Pro Ala Ile Asn Val Gly Leu Ser Val Ser Arg Val Gly 
        355                 360                 365             


Ser Ala Ala Gln Xaa Arg Ala Met Lys Gln Val Ala Gly Xaa Met Lys 
    370                 375                 380                 


Leu Glu Leu Ala Gln Tyr Arg Glu Val Ala Ala Phe Ala Gln Phe Gly 
385                 390                 395                 400 


Ser Asp Leu Asp Ala Ala Xaa Gln Gln Leu Leu Ser Arg Gly Val Arg 
                405                 410                 415     


Leu Xaa Glu Leu Leu Lys Gln Gly Gln Tyr Ser Pro Met Ala Ile Glu 
            420                 425                 430         


Glu Gln Val Ala Val Ile Tyr Ala Gly Val Arg Gly Tyr Leu Asp Lys 
        435                 440                 445             


Leu Glu Pro Ser Lys Ile Xaa Lys Phe Glu Asn Ala Phe Leu Ser His 
    450                 455                 460                 


Val Val Ser Gln His Gln Ala Leu Leu Gly Xaa Ile Arg Ala Asp Gly 
465                 470                 475                 480 


Lys Ile Ser Glu Gln Ser Asp Ala Lys Leu Lys Glu Ile Val Xaa Asn 
                485                 490                 495     


Phe Leu Ala Gly Phe Glu Ala 
            500             


<210> 3567
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<400> 3567
Met Val Ile Leu Trp Arg Lys Lys Lys Ser Pro Ser Arg Ser Pro Glu 
1               5                   10                  15      


Met Leu Trp Val His Leu Ser Leu Leu Gln Gly Xaa Ser Met Pro Leu 
            20                  25                  30          


Xaa Leu Ile Phe Lys Arg Leu Arg Trp Asp Phe Ala Val Leu Ala Arg 
        35                  40                  45              


Leu Val Gln Xaa Leu Gly Leu Lys Trp Ser Ala Arg Leu Pro Lys Cys 
    50                  55                  60                  


Trp Tyr Tyr Trp Arg Glu Pro Leu His Pro Xaa Pro Val Cys 
65                  70                  75              


<210> 3568
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<400> 3568
Ala Gln Ala Leu Trp Arg Met Pro Trp Leu Pro Val Phe Leu Ser Leu 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Gln Gln Val Pro Leu Val 
            20                  25                  30          


Leu Trp Ser Ser Asp Arg Asp Leu Trp Ala Pro Ala Ala Asp Xaa His 
        35                  40                  45              


Glu Gly His Ile Xaa Ser Asp Leu Gln Leu Ser Xaa Tyr Leu Asp Pro 
    50                  55                  60                  


Ala Leu Glu Leu Gly Pro Arg Asn Val Leu Leu Phe Leu Gln Asp Lys 
65                  70                  75                  80  


Leu Ser Ile Glu Asp Phe Xaa Ala Tyr Gly Gly Val Phe Gly Asn Lys 
                85                  90                  95      


Gln Asp Ser Ala Phe Ser Asn Leu Glu His Xaa Gln Val Arg Arg Cys 
            100                 105                 110         


Pro Ile His Ser Gly Pro His Ser Gly Pro Pro Phe Gln Gly Gly Pro 
        115                 120                 125             


<210> 3569
<211> 281
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<400> 3569
Met Ala Pro Arg Glu Val Leu Xaa Gly Asn Asp Glu Val Ile Gly Gln 
1               5                   10                  15      


Val Leu Ser Xaa Leu Lys Ser Glu Asp Val Pro Tyr Xaa Ala Ala Leu 
            20                  25                  30          


Xaa Ala Val Arg Pro Ser Arg Val Ala Arg Asp Val Ala Val Val Ala 
        35                  40                  45              


Gly Gly Leu Gly Arg Gln Leu Leu Gln Lys Gln Pro Val Ser Pro Val 
    50                  55                  60                  


Ile His Pro Pro Val Ser Tyr Asn Asp Xaa Ala Pro Arg Ile Leu Phe 
65                  70                  75                  80  


Trp Ala Gln Asn Phe Ser Val Ala Tyr Lys Asp Gln Trp Glu Asp Leu 
                85                  90                  95      


Xaa Pro Leu Xaa Phe Gly Val Gln Glu Leu Asn Leu Xaa Gly Ser Phe 
            100                 105                 110         


Trp Asn Asp Ser Phe Ala Arg Leu Ser Leu Xaa Tyr Glu Arg Leu Phe 
        115                 120                 125             


Gly Xaa Xaa Val Xaa Phe Lys Phe Ile Leu Ala Asn Arg Leu Tyr Pro 
    130                 135                 140                 


Val Ser Ala Arg His Trp Phe Xaa Met Glu Arg Leu Glu Val His Ser 
145                 150                 155                 160 


Asn Gly Ser Val Ala Tyr Phe Asn Ala Ser Gln Val Xaa Gly Pro Ser 
                165                 170                 175     


Ile Tyr Ser Phe His Cys Glu Tyr Val Ser Ser Leu Ser Lys Lys Gly 
            180                 185                 190         


Ser Leu Leu Val Ala Arg Xaa Gln Pro Ser Pro Trp Gln Met Met Leu 
        195                 200                 205             


Gln Asp Phe Gln Ile Gln Ala Phe Asn Val Met Gly Glu Gln Phe Ser 
    210                 215                 220                 


Tyr Ala Ser Asp Cys Ala Ser Phe Phe Ser Pro Gly Ile Trp Met Gly 
225                 230                 235                 240 


Leu Leu Xaa Ser Leu Phe Met Leu Phe Ile Phe Xaa Tyr Gly Leu His 
                245                 250                 255     


Met Ile Leu Ser Leu Lys Xaa Met Asp Arg Phe Asp Asp His Lys Gly 
            260                 265                 270         


Pro Xaa Ile Ser Leu Xaa Gln Ile Val 
        275                 280     


<210> 3570
<211> 273
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<400> 3570
Met Met Ala Ala Met Ala Xaa Ala Arg Val Arg Met Gly Pro Arg Cys 
1               5                   10                  15      


Ala Gln Ala Leu Trp Arg Met Pro Trp Leu Pro Val Phe Leu Ser Leu 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Gln Gln Val Pro Leu Val 
        35                  40                  45              


Leu Trp Ser Ser Asp Arg Asp Leu Trp Ala Pro Ala Ala Asp Xaa His 
    50                  55                  60                  


Glu Gly His Ile Xaa Ser Asp Leu Gln Leu Ser Xaa Tyr Leu Asp Pro 
65                  70                  75                  80  


Ala Leu Glu Leu Gly Pro Arg Asn Val Leu Leu Phe Leu Gln Asp Lys 
                85                  90                  95      


Leu Ser Ile Glu Asp Phe Xaa Ala Tyr Gly Gly Val Phe Gly Asn Lys 
            100                 105                 110         


Gln Asp Ser Ala Phe Ser Asn Leu Glu Asn Ala Leu Asp Leu Ala Pro 
        115                 120                 125             


Ser Ser Leu Val Leu Pro Ala Val Asp Trp Tyr Ala Val Ser Xaa Leu 
    130                 135                 140                 


Xaa Xaa Tyr Leu Gln Glu Lys Leu Gly Ala Ser Pro Leu His Val Ala 
145                 150                 155                 160 


Arg Asp Val Ala Val Val Ala Gly Gly Leu Gly Arg Gln Leu Leu Gln 
                165                 170                 175     


Lys Gln Pro Val Ser Pro Val Ile His Pro Pro Val Ser Tyr Asn Asp 
            180                 185                 190         


Xaa Ala Pro Arg Ile Leu Phe Trp Ala Gln Asn Phe Ser Val Ala Tyr 
        195                 200                 205             


Lys Asp Gln Trp Glu Asp Leu Xaa Pro Leu Xaa Phe Gly Val Gln Glu 
    210                 215                 220                 


Leu Asn Leu Xaa Gly Ser Phe Trp Asn Asp Ser Phe Ala Arg Phe Ile 
225                 230                 235                 240 


Leu Ala Asn Arg Leu Tyr Pro Val Ser Ala Arg His Trp Phe Xaa Met 
                245                 250                 255     


Glu Arg Leu Glu Val His Ser Asn Gly Ser Val Ala Tyr Phe Asn Ala 
            260                 265                 270         


Ser 
    


<210> 3571
<211> 230
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<400> 3571
Met Met Ala Ala Met Ala Xaa Ala Arg Val Arg Met Gly Pro Arg Cys 
1               5                   10                  15      


Ala Gln Ala Leu Trp Arg Met Pro Trp Leu Pro Val Phe Leu Ser Leu 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Gln Gln Val Pro Leu Val 
        35                  40                  45              


Leu Trp Ser Ser Asp Arg Asp Leu Trp Ala Pro Ala Ala Asp Xaa His 
    50                  55                  60                  


Glu Gly His Ile Xaa Ser Asp Leu Gln Leu Ser Xaa Tyr Leu Asp Pro 
65                  70                  75                  80  


Ala Leu Glu Leu Gly Pro Arg Asn Val Leu Leu Phe Leu Gln Asp Lys 
                85                  90                  95      


Leu Ser Ile Glu Asp Phe Xaa Ala Tyr Gly Gly Val Phe Gly Asn Lys 
            100                 105                 110         


Gln Asp Ser Ala Phe Ser Asn Leu Glu Asn Ala Leu Asp Leu Ala Pro 
        115                 120                 125             


Ser Ser Leu Val Leu Pro Ala Val Asp Trp Tyr Ala Val Ser Xaa Leu 
    130                 135                 140                 


Xaa Xaa Tyr Leu Gln Glu Lys Leu Gly Ala Ser Pro Leu His Val Asp 
145                 150                 155                 160 


Leu Ala Xaa Leu Arg Glu Leu Lys Leu Asn Ala Ser Leu Pro Ala Leu 
                165                 170                 175     


Leu Leu Ile Arg Leu Pro Tyr Xaa Ala Ser Ser Gly Leu Met Ala Pro 
            180                 185                 190         


Arg Glu Val Leu Xaa Asp Glu Val Ile Gly Gln Val Leu Ser Xaa Leu 
        195                 200                 205             


Lys Ser Glu Asp Val Pro Tyr Xaa Ala Ala Leu Xaa Ala Val Arg Pro 
    210                 215                 220                 


Ser Arg Val Ala Arg Asp 
225                 230 


<210> 3572
<211> 470
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<400> 3572
Met Met Ala Ala Met Ala Xaa Ala Arg Val Arg Met Gly Pro Arg Cys 
1               5                   10                  15      


Ala Gln Ala Leu Trp Arg Met Pro Trp Leu Pro Val Phe Leu Ser Leu 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Gln Gln Val Pro Leu Val 
        35                  40                  45              


Leu Trp Ser Ser Asp Arg Asp Leu Trp Ala Pro Ala Ala Asp Xaa His 
    50                  55                  60                  


Glu Gly His Ile Xaa Ser Asp Leu Gln Leu Ser Xaa Tyr Leu Asp Pro 
65                  70                  75                  80  


Ala Leu Glu Leu Gly Pro Arg Asn Val Leu Leu Phe Leu Gln Asp Lys 
                85                  90                  95      


Leu Ser Ile Glu Asp Phe Xaa Ala Tyr Gly Gly Val Phe Gly Asn Lys 
            100                 105                 110         


Gln Asp Ser Ala Phe Ser Asn Leu Glu Asn Ala Leu Asp Leu Ala Pro 
        115                 120                 125             


Ser Ser Leu Val Leu Pro Ala Val Asp Trp Tyr Ala Val Ser Xaa Leu 
    130                 135                 140                 


Xaa Xaa Tyr Leu Gln Glu Lys Leu Gly Ala Ser Pro Leu His Val Asp 
145                 150                 155                 160 


Leu Ala Xaa Leu Arg Glu Leu Lys Leu Asn Ala Ser Leu Pro Ala Leu 
                165                 170                 175     


Leu Leu Ile Arg Leu Pro Tyr Xaa Ala Ser Ser Gly Leu Met Ala Pro 
            180                 185                 190         


Arg Glu Val Leu Xaa Gly Asn Asp Glu Val Ile Gly Gln Val Leu Ser 
        195                 200                 205             


Xaa Leu Lys Ser Glu Asp Val Pro Tyr Xaa Ala Ala Leu Xaa Ala Val 
    210                 215                 220                 


Arg Pro Ser Arg Val Ala Arg Asp Val Ala Val Val Ala Gly Gly Leu 
225                 230                 235                 240 


Gly Arg Gln Leu Leu Gln Lys Gln Pro Val Ser Pro Val Ile His Pro 
                245                 250                 255     


Pro Val Ser Tyr Asn Asp Xaa Ala Pro Arg Ile Leu Phe Trp Ala Gln 
            260                 265                 270         


Asn Phe Ser Val Ala Tyr Lys Asp Gln Trp Glu Asp Leu Xaa Pro Leu 
        275                 280                 285             


Xaa Phe Gly Val Gln Glu Leu Asn Leu Xaa Gly Ser Phe Trp Asn Asp 
    290                 295                 300                 


Ser Phe Ala Arg Leu Ser Leu Xaa Tyr Glu Arg Leu Phe Gly Xaa Xaa 
305                 310                 315                 320 


Val Xaa Phe Lys Phe Ile Leu Ala Asn Arg Leu Tyr Pro Val Ser Ala 
                325                 330                 335     


Arg His Trp Phe Xaa Met Glu Arg Leu Glu Val His Ser Asn Gly Ser 
            340                 345                 350         


Val Ala Tyr Phe Asn Ala Ser Gln Val Xaa Gly Pro Ser Ile Tyr Ser 
        355                 360                 365             


Phe His Cys Glu Tyr Val Ser Ser Leu Ser Lys Lys Gly Ser Leu Leu 
    370                 375                 380                 


Val Ala Arg Xaa Gln Pro Ser Pro Trp Gln Met Met Leu Gln Asp Phe 
385                 390                 395                 400 


Gln Ile Gln Ala Phe Asn Val Met Gly Glu Gln Phe Ser Tyr Ala Ser 
                405                 410                 415     


Asp Cys Ala Ser Phe Phe Ser Pro Gly Ile Trp Met Gly Leu Leu Xaa 
            420                 425                 430         


Ser Leu Phe Met Leu Phe Ile Phe Xaa Tyr Gly Leu His Met Ile Leu 
        435                 440                 445             


Ser Leu Lys Xaa Met Asp Arg Phe Asp Asp His Lys Gly Pro Xaa Ile 
    450                 455                 460                 


Ser Leu Xaa Gln Ile Val 
465                 470 


<210> 3573
<211> 134
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 3573
Met Met Ala Ala Met Ala Xaa Ala Arg Val Arg Met Gly Pro Arg Cys 
1               5                   10                  15      


Ala Gln Ala Leu Trp Arg Met Pro Trp Leu Pro Val Phe Leu Ser Leu 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Gln Gln Val Pro Leu Val 
        35                  40                  45              


Leu Trp Ser Ser Asp Arg Asp Leu Trp Ala Pro Ala Ala Asp Xaa His 
    50                  55                  60                  


Glu Gly His Ile Xaa Ser Asp Leu Gln Leu Ser Xaa Tyr Leu Asp Pro 
65                  70                  75                  80  


Ala Leu Glu Leu Gly Pro Arg Asn Val Leu Leu Phe Leu Gln Asp Lys 
                85                  90                  95      


Val Arg Pro Pro Gln Pro Xaa Leu Pro Arg Ser Ser Gly Gly Ser Gln 
            100                 105                 110         


Ala Pro Ser Pro His Asp Xaa Asp Ala His Ser Pro Arg Glu Ala Ser 
        115                 120                 125             


Val Xaa Leu Ser Gln Leu 
    130                 


<210> 3574
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 3574
Xaa Ala Ala Met Ala Xaa Ala Arg Val Arg Met Gly Pro Arg Cys Ala 
1               5                   10                  15      


Gln Ala Leu Trp Arg Met Pro Trp Leu Pro Val Phe Leu Ser Leu Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Glu Gln Gln Val Pro Leu Val Leu 
        35                  40                  45              


Trp Ser Ser Asp Arg Asp Leu Trp Ala Pro Ala Ala Asp Xaa His Glu 
    50                  55                  60                  


Gly His Ile Xaa Ser Asp Leu Gln Leu Ser Xaa Tyr Leu Asp Pro Ala 
65                  70                  75                  80  


Leu Glu Leu Gly Pro Arg Asn Val Leu Leu Phe Leu Gln Asp Lys Val 
                85                  90                  95      


Arg Pro Pro Gln Pro Xaa Leu Pro Arg Ser Ser Gly Gly Ser Gln Ala 
            100                 105                 110         


Pro Ser Pro His Asp Xaa Asp Ala His Ser Pro Arg Glu Ala Ser Val 
        115                 120                 125             


Xaa Leu Ser Gln Leu 
    130             


<210> 3575
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<400> 3575
Phe His Arg Pro Arg Ala Xaa Val Met Val Met Val Lys Gly Val Asn 
1               5                   10                  15      


Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr Pro Leu Glu Asn 
            20                  25                  30          


Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser Pro Asp Leu Tyr 
        35                  40                  45              


Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys Arg Tyr Gly Glu 
    50                  55                  60                  


Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu Val Asp Ala Leu 
65                  70                  75                  80  


Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly Gly Asn Ala Val 
                85                  90                  95      


Val Glu Leu Val Xaa Val Lys Ser Phe Asp Xaa Ser Leu Ile Arg Lys 
            100                 105                 110         


Xaa Arg Xaa Ile Leu Glu Ala Lys Gln Ala Lys Asn Pro Ala Ser Pro 
        115                 120                 125             


Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser Val Val Phe Asn 
    130                 135                 140                 


Met Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala Val Ile Ile Xaa 
145                 150                 155                 160 


Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp Ser Ile Ile Tyr 
                165                 170                 175     


Arg Met Xaa Asn Gln Lys Ile Arg Met Asp 
            180                 185     


<210> 3576
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 3576
Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Xaa Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Xaa Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
    130                 135                 140                 


Glu Asp Leu Ser Val Xaa Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
145                 150                 155                 160 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
                165                 170                 175     


Asn Glu Asn Ala Leu Phe Phe Trp Ala Leu 
            180                 185     


<210> 3577
<211> 209
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<400> 3577
Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Xaa Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Xaa Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
    130                 135                 140                 


Glu Asp Leu Ser Val Xaa Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
145                 150                 155                 160 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
                165                 170                 175     


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
            180                 185                 190         


Ile Ser Ser Leu Gly Glu Xaa Xaa Tyr Leu Pro Arg Xaa Gln Ala Trp 
        195                 200                 205             


Ala 
    


<210> 3578
<211> 345
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<400> 3578
Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Xaa Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Xaa Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
    130                 135                 140                 


Glu Asp Leu Ser Val Xaa Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
145                 150                 155                 160 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
                165                 170                 175     


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
            180                 185                 190         


Ile Ser Ser Leu His Leu Ala Lys Asp His Ser Pro Asp Leu Tyr Ser 
        195                 200                 205             


Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys Arg Tyr Gly Glu Asp 
    210                 215                 220                 


Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu Val Asp Ala Leu Gln 
225                 230                 235                 240 


Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly Gly Asn Ala Val Val 
                245                 250                 255     


Glu Leu Val Xaa Val Lys Ser Phe Asp Xaa Ser Leu Ile Arg Lys Xaa 
            260                 265                 270         


Arg Xaa Ile Leu Glu Ala Lys Gln Ala Lys Asn Pro Ala Ser Pro Tyr 
        275                 280                 285             


Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser Val Val Phe Asn Met 
    290                 295                 300                 


Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala Val Ile Ile Xaa Ser 
305                 310                 315                 320 


Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp Ser Ile Ile Tyr Arg 
                325                 330                 335     


Met Xaa Asn Gln Lys Ile Arg Met Asp 
            340                 345 


<210> 3579
<211> 331
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<400> 3579
Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Xaa Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Xaa Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
    130                 135                 140                 


Glu Asp Leu Ser Val Xaa Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
145                 150                 155                 160 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
                165                 170                 175     


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
            180                 185                 190         


Ile Ser Ser Leu Leu Ala Gly Leu Asp Glu Ile Gly Lys Arg Tyr Gly 
        195                 200                 205             


Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu Val Asp Ala 
    210                 215                 220                 


Leu Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly Gly Asn Ala 
225                 230                 235                 240 


Val Val Glu Leu Val Xaa Val Lys Ser Phe Asp Xaa Ser Leu Ile Arg 
                245                 250                 255     


Lys Xaa Arg Xaa Ile Leu Glu Ala Lys Gln Ala Lys Asn Pro Ala Ser 
            260                 265                 270         


Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser Val Val Phe 
        275                 280                 285             


Asn Met Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala Val Ile Ile 
    290                 295                 300                 


Xaa Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp Ser Ile Ile 
305                 310                 315                 320 


Tyr Arg Met Xaa Asn Gln Lys Ile Arg Met Asp 
                325                 330     


<210> 3580
<211> 349
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<400> 3580
Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Xaa Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Xaa Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
    130                 135                 140                 


Glu Asp Leu Ser Val Xaa Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
145                 150                 155                 160 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
                165                 170                 175     


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
            180                 185                 190         


Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser 
        195                 200                 205             


Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys 
    210                 215                 220                 


Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu 
225                 230                 235                 240 


Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly 
                245                 250                 255     


Gly Asn Ala Val Val Glu Leu Val Xaa Val Lys Ser Phe Asp Xaa Ser 
            260                 265                 270         


Leu Ile Arg Lys Xaa Arg Xaa Ile Leu Glu Ala Lys Gln Ala Asn Pro 
        275                 280                 285             


Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser Val 
    290                 295                 300                 


Val Phe Asn Met Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala Val 
305                 310                 315                 320 


Ile Ile Xaa Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp Ser 
                325                 330                 335     


Ile Ile Tyr Arg Met Xaa Asn Gln Lys Ile Arg Met Asp 
            340                 345                 


<210> 3581
<211> 350
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<400> 3581
Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Xaa Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Xaa Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
    130                 135                 140                 


Glu Asp Leu Ser Val Xaa Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
145                 150                 155                 160 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
                165                 170                 175     


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
            180                 185                 190         


Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser 
        195                 200                 205             


Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys 
    210                 215                 220                 


Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu 
225                 230                 235                 240 


Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly 
                245                 250                 255     


Gly Asn Ala Val Val Glu Leu Val Xaa Val Lys Ser Phe Asp Xaa Ser 
            260                 265                 270         


Leu Ile Arg Lys Xaa Arg Xaa Ile Leu Glu Ala Lys Gln Ala Lys Asn 
        275                 280                 285             


Pro Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser 
    290                 295                 300                 


Val Val Phe Asn Met Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala 
305                 310                 315                 320 


Val Ile Ile Xaa Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp 
                325                 330                 335     


Ser Ile Ile Tyr Arg Met Xaa Asn Gln Lys Ile Arg Met Asp 
            340                 345                 350 


<210> 3582
<211> 258
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<400> 3582
Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Xaa Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Xaa Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
    130                 135                 140                 


Glu Asp Leu Ser Val Xaa Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
145                 150                 155                 160 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
                165                 170                 175     


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
            180                 185                 190         


Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser 
        195                 200                 205             


Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys 
    210                 215                 220                 


Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu 
225                 230                 235                 240 


Val Asp Ala Leu Gln Lys Met Xaa Cys Xaa Val Phe Met Val Gly Met 
                245                 250                 255     


Gln Trp 
        


<210> 3583
<211> 262
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 3583
Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Xaa Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Xaa Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
    130                 135                 140                 


Glu Asp Leu Ser Val Xaa Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
145                 150                 155                 160 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
                165                 170                 175     


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
            180                 185                 190         


Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser 
        195                 200                 205             


Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys 
    210                 215                 220                 


Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu 
225                 230                 235                 240 


Val Asp Ala Leu Gln Lys Ser Leu Trp Trp Glu Cys Ser Gly Arg Val 
                245                 250                 255     


Ser His Cys Gln Val Ile 
            260         


<210> 3584
<211> 143
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<400> 3584
Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Xaa Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Xaa Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Ser Val Tyr Gly Arg Glu Gly Lys Leu Ser Val 
    130                 135                 140             


<210> 3585
<211> 318
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<400> 3585
Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Xaa Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
            100                 105                 110         


Glu Asp Leu Ser Val Xaa Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
        115                 120                 125             


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
    130                 135                 140                 


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
145                 150                 155                 160 


Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser 
                165                 170                 175     


Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys 
            180                 185                 190         


Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu 
        195                 200                 205             


Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly 
    210                 215                 220                 


Gly Asn Ala Val Val Glu Leu Val Xaa Val Lys Ser Phe Asp Xaa Ser 
225                 230                 235                 240 


Leu Ile Arg Lys Xaa Arg Xaa Ile Leu Glu Ala Lys Gln Ala Lys Asn 
                245                 250                 255     


Pro Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser 
            260                 265                 270         


Val Val Phe Asn Met Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala 
        275                 280                 285             


Val Ile Ile Xaa Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp 
    290                 295                 300                 


Ser Ile Ile Tyr Arg Met Xaa Asn Gln Lys Ile Arg Met Asp 
305                 310                 315             


<210> 3586
<211> 317
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<400> 3586
Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Xaa Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
            100                 105                 110         


Glu Asp Leu Ser Val Xaa Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
        115                 120                 125             


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
    130                 135                 140                 


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
145                 150                 155                 160 


Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser 
                165                 170                 175     


Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys 
            180                 185                 190         


Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu 
        195                 200                 205             


Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly 
    210                 215                 220                 


Gly Asn Ala Val Val Glu Leu Val Xaa Val Lys Ser Phe Asp Xaa Ser 
225                 230                 235                 240 


Leu Ile Arg Lys Xaa Arg Xaa Ile Leu Glu Ala Lys Gln Ala Asn Pro 
                245                 250                 255     


Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser Val 
            260                 265                 270         


Val Phe Asn Met Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala Val 
        275                 280                 285             


Ile Ile Xaa Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp Ser 
    290                 295                 300                 


Ile Ile Tyr Arg Met Xaa Asn Gln Lys Ile Arg Met Asp 
305                 310                 315         


<210> 3587
<211> 272
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<400> 3587
Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Xaa Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu 
            100                 105                 110         


His Asp Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp 
        115                 120                 125             


His Ser Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile 
    130                 135                 140                 


Gly Lys Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys 
145                 150                 155                 160 


Ile Leu Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu 
                165                 170                 175     


Tyr Gly Gly Asn Ala Val Val Glu Leu Val Xaa Val Lys Ser Phe Asp 
            180                 185                 190         


Xaa Ser Leu Ile Arg Lys Xaa Arg Xaa Ile Leu Glu Ala Lys Gln Ala 
        195                 200                 205             


Lys Asn Pro Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu 
    210                 215                 220                 


Tyr Ser Val Val Phe Asn Met Val Leu Trp Ile Met Ile Ala Leu Ala 
225                 230                 235                 240 


Leu Ala Val Ile Ile Xaa Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly 
                245                 250                 255     


Tyr Asp Ser Ile Ile Tyr Arg Met Xaa Asn Gln Lys Ile Arg Met Asp 
            260                 265                 270         


<210> 3588
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<400> 3588
Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala Val 
1               5                   10                  15      


Gly Asn Leu Phe His Arg Pro Arg Ala Xaa Val Met Val Met Val Lys 
            20                  25                  30          


Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr Pro 
        35                  40                  45              


Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser Ile 
    50                  55                  60                  


His Ser Leu Phe Ser Glu Glu Xaa Pro Val Val Leu Gln Leu Ala Pro 
65                  70                  75                  80  


Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe Glu 
                85                  90                  95      


Asp Leu Ser Val Xaa Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln Glu 
            100                 105                 110         


Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn Asn 
        115                 120                 125             


<210> 3589
<211> 301
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<400> 3589
Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala Val 
1               5                   10                  15      


Gly Asn Leu Phe His Arg Pro Arg Ala Xaa Val Met Val Met Val Lys 
            20                  25                  30          


Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr Pro 
        35                  40                  45              


Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser Ile 
    50                  55                  60                  


His Ser Leu Phe Ser Glu Glu Xaa Pro Val Val Leu Gln Leu Ala Pro 
65                  70                  75                  80  


Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe Glu 
                85                  90                  95      


Asp Leu Ser Val Xaa Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln Glu 
            100                 105                 110         


Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn Asn 
        115                 120                 125             


Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp Ile 
    130                 135                 140                 


Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser Pro 
145                 150                 155                 160 


Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys Arg 
                165                 170                 175     


Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu Val 
            180                 185                 190         


Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly Gly 
        195                 200                 205             


Asn Ala Val Val Glu Leu Val Xaa Val Lys Ser Phe Asp Xaa Ser Leu 
    210                 215                 220                 


Ile Arg Lys Xaa Arg Xaa Ile Leu Glu Ala Lys Gln Ala Lys Asn Pro 
225                 230                 235                 240 


Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser Val 
                245                 250                 255     


Val Phe Asn Met Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala Val 
            260                 265                 270         


Ile Ile Xaa Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp Ser 
        275                 280                 285             


Ile Ile Tyr Arg Met Xaa Asn Gln Lys Ile Arg Met Asp 
    290                 295                 300     


<210> 3590
<211> 274
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<400> 3590
Met Val Met Val Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser 
1               5                   10                  15      


Val Ile Ser Tyr Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser 
            20                  25                  30          


Val Ala Asn Ser Ile His Ser Leu Phe Ser Glu Glu Xaa Pro Val Val 
        35                  40                  45              


Leu Gln Leu Ala Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala 
    50                  55                  60                  


Asn Ser Val Phe Glu Asp Leu Ser Val Xaa Leu Arg Gln Leu Arg Asn 
65                  70                  75                  80  


Arg Leu Phe Gln Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser 
                85                  90                  95      


Leu Ser Arg Asn Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln 
            100                 105                 110         


Val Leu His Asp Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala 
        115                 120                 125             


Lys Asp His Ser Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp 
    130                 135                 140                 


Glu Ile Gly Lys Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala 
145                 150                 155                 160 


Ser Lys Ile Leu Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr 
                165                 170                 175     


Ser Leu Tyr Gly Gly Asn Ala Val Val Glu Leu Val Xaa Val Lys Ser 
            180                 185                 190         


Phe Asp Xaa Ser Leu Ile Arg Lys Xaa Arg Xaa Ile Leu Glu Ala Lys 
        195                 200                 205             


Gln Ala Lys Asn Pro Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn 
    210                 215                 220                 


Phe Glu Tyr Ser Val Val Phe Asn Met Val Leu Trp Ile Met Ile Ala 
225                 230                 235                 240 


Leu Ala Leu Ala Val Ile Ile Xaa Ser Tyr Asn Ile Trp Asn Met Asp 
                245                 250                 255     


Pro Gly Tyr Asp Ser Ile Ile Tyr Arg Met Xaa Asn Gln Lys Ile Arg 
            260                 265                 270         


Met Asp 
        


<210> 3591
<211> 273
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<400> 3591
Met Val Met Val Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser 
1               5                   10                  15      


Val Ile Ser Tyr Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser 
            20                  25                  30          


Val Ala Asn Ser Ile His Ser Leu Phe Ser Glu Glu Xaa Pro Val Val 
        35                  40                  45              


Leu Gln Leu Ala Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala 
    50                  55                  60                  


Asn Ser Val Phe Glu Asp Leu Ser Val Xaa Leu Arg Gln Leu Arg Asn 
65                  70                  75                  80  


Arg Leu Phe Gln Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser 
                85                  90                  95      


Leu Ser Arg Asn Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln 
            100                 105                 110         


Val Leu His Asp Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala 
        115                 120                 125             


Lys Asp His Ser Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp 
    130                 135                 140                 


Glu Ile Gly Lys Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala 
145                 150                 155                 160 


Ser Lys Ile Leu Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr 
                165                 170                 175     


Ser Leu Tyr Gly Gly Asn Ala Val Val Glu Leu Val Xaa Val Lys Ser 
            180                 185                 190         


Phe Asp Xaa Ser Leu Ile Arg Lys Xaa Arg Xaa Ile Leu Glu Ala Lys 
        195                 200                 205             


Gln Ala Asn Pro Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe 
    210                 215                 220                 


Glu Tyr Ser Val Val Phe Asn Met Val Leu Trp Ile Met Ile Ala Leu 
225                 230                 235                 240 


Ala Leu Ala Val Ile Ile Xaa Ser Tyr Asn Ile Trp Asn Met Asp Pro 
                245                 250                 255     


Gly Tyr Asp Ser Ile Ile Tyr Arg Met Xaa Asn Gln Lys Ile Arg Met 
            260                 265                 270         


Asp 
    


<210> 3592
<211> 59
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<400> 3592
Met Val Met Val Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser 
1               5                   10                  15      


Val Ile Ser Tyr Pro Leu Glu Asn Phe Leu Leu Val Leu Xaa Val Leu 
            20                  25                  30          


Gln Ile Pro Phe Xaa Pro Tyr Phe Leu Arg Lys Leu Leu Leu Phe Cys 
        35                  40                  45              


Ser Trp Leu Pro Val Arg Lys Glu Cys Ile Trp 
    50                  55                  


<210> 3593
<211> 101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<400> 3593
Met Val Met Val Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser 
1               5                   10                  15      


Val Ile Ser Tyr Pro Leu Glu Asn Arg Val Tyr Met Val Gly Lys Ala 
            20                  25                  30          


Asn Ser Val Phe Glu Asp Leu Ser Val Xaa Leu Arg Gln Leu Arg Asn 
        35                  40                  45              


Arg Leu Phe Gln Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser 
    50                  55                  60                  


Leu Ser Arg Asn Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln 
65                  70                  75                  80  


Val Leu His Asp Ile Ser Ser Leu Gly Glu Xaa Xaa Tyr Leu Pro Arg 
                85                  90                  95      


Xaa Gln Ala Trp Ala 
            100     


<210> 3594
<211> 242
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<400> 3594
Met Val Met Val Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser 
1               5                   10                  15      


Val Ile Ser Tyr Pro Leu Glu Asn Arg Val Tyr Met Val Gly Lys Ala 
            20                  25                  30          


Asn Ser Val Phe Glu Asp Leu Ser Val Xaa Leu Arg Gln Leu Arg Asn 
        35                  40                  45              


Arg Leu Phe Gln Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser 
    50                  55                  60                  


Leu Ser Arg Asn Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln 
65                  70                  75                  80  


Val Leu His Asp Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala 
                85                  90                  95      


Lys Asp His Ser Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp 
            100                 105                 110         


Glu Ile Gly Lys Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala 
        115                 120                 125             


Ser Lys Ile Leu Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr 
    130                 135                 140                 


Ser Leu Tyr Gly Gly Asn Ala Val Val Glu Leu Val Xaa Val Lys Ser 
145                 150                 155                 160 


Phe Asp Xaa Ser Leu Ile Arg Lys Xaa Arg Xaa Ile Leu Glu Ala Lys 
                165                 170                 175     


Gln Ala Lys Asn Pro Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn 
            180                 185                 190         


Phe Glu Tyr Ser Val Val Phe Asn Met Val Leu Trp Ile Met Ile Ala 
        195                 200                 205             


Leu Ala Leu Ala Val Ile Ile Xaa Ser Tyr Asn Ile Trp Asn Met Asp 
    210                 215                 220                 


Pro Gly Tyr Asp Ser Ile Ile Tyr Arg Met Xaa Asn Gln Lys Ile Arg 
225                 230                 235                 240 


Met Asp 
        


<210> 3595
<211> 196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<400> 3595
Met Val Met Val Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser 
1               5                   10                  15      


Val Ile Ser Tyr Pro Leu Glu Asn Val Asp Leu Leu Phe Leu Ser Glu 
            20                  25                  30          


Leu Gln Val Leu His Asp Ile Ser Ser Leu Leu Ser Arg His Lys His 
        35                  40                  45              


Leu Ala Lys Asp His Ser Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly 
    50                  55                  60                  


Leu Asp Glu Ile Gly Lys Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg 
65                  70                  75                  80  


Asp Ala Ser Lys Ile Leu Val Asp Ala Leu Gln Lys Phe Ala Asp Asp 
                85                  90                  95      


Met Tyr Ser Leu Tyr Gly Gly Asn Ala Val Val Glu Leu Val Xaa Val 
            100                 105                 110         


Lys Ser Phe Asp Xaa Ser Leu Ile Arg Lys Xaa Arg Xaa Ile Leu Glu 
        115                 120                 125             


Ala Lys Gln Ala Lys Asn Pro Ala Ser Pro Tyr Asn Leu Ala Tyr Lys 
    130                 135                 140                 


Tyr Asn Phe Glu Tyr Ser Val Val Phe Asn Met Val Leu Trp Ile Met 
145                 150                 155                 160 


Ile Ala Leu Ala Leu Ala Val Ile Ile Xaa Ser Tyr Asn Ile Trp Asn 
                165                 170                 175     


Met Asp Pro Gly Tyr Asp Ser Ile Ile Tyr Arg Met Xaa Asn Gln Lys 
            180                 185                 190         


Ile Arg Met Asp 
        195     


<210> 3596
<211> 294
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<400> 3596
Xaa Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
1               5                   10                  15      


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
            20                  25                  30          


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
        35                  40                  45              


Val Gly Asn Leu Phe His Arg Pro Arg Ala Xaa Val Met Val Met Val 
    50                  55                  60                  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
65                  70                  75                  80  


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
                85                  90                  95      


Ile His Ser Leu Phe Ser Glu Glu Xaa Pro Val Val Leu Gln Leu Ala 
            100                 105                 110         


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
        115                 120                 125             


Glu Asp Leu Ser Val Xaa Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
    130                 135                 140                 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
145                 150                 155                 160 


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
                165                 170                 175     


Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser 
            180                 185                 190         


Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys 
        195                 200                 205             


Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu 
    210                 215                 220                 


Val Asp Ala Leu Gln Lys Lys Asn Pro Ala Ser Pro Tyr Asn Leu Ala 
225                 230                 235                 240 


Tyr Lys Tyr Asn Phe Glu Tyr Ser Val Val Phe Asn Met Val Leu Trp 
                245                 250                 255     


Ile Met Ile Ala Leu Ala Leu Ala Val Ile Ile Xaa Ser Tyr Asn Ile 
            260                 265                 270         


Trp Asn Met Asp Pro Gly Tyr Asp Ser Ile Ile Tyr Arg Met Xaa Asn 
        275                 280                 285             


Gln Lys Ile Arg Met Asp 
    290                 


<210> 3597
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<400> 3597
Xaa Ser Leu Tyr Gly Gly Asn Ala Val Val Glu Leu Val Xaa Val Lys 
1               5                   10                  15      


Ser Phe Asp Xaa Ser Leu Ile Arg Lys Xaa Arg Xaa Ile Leu Glu Ala 
            20                  25                  30          


Lys Gln Ala Glu Lys Glu His Val Tyr Gln Lys Lys Lys Lys Glu Arg 
        35                  40                  45              


Asn Lys Glu Val Phe Met Gly Val Lys Ser Phe Asn Val Cys Leu Ser 
    50                  55                  60                  


Ser Glu Leu Pro Ala Glu Glu Pro Ser Lys Ser Leu 
65                  70                  75      


<210> 3598
<211> 195
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<400> 3598
Ala Asn Ile Pro Ile Met Asp Xaa Gly Glu Asn Pro Glu Val Pro Phe 
1               5                   10                  15      


Pro Arg Asp Met Ile Asp Leu Glu Ala Asn Phe Glu Lys Ile Glu Asn 
            20                  25                  30          


Glu Leu Lys Glu Ile Asn Xaa Asn Gln Glu Ala Leu Lys Arg Asn Phe 
        35                  40                  45              


Leu Glu Leu Xaa Glu Leu Lys Phe Ile Leu Arg Lys Xaa Gln Gln Phe 
    50                  55                  60                  


Phe Asp Glu Met Ala Asp Pro Asp Leu Leu Glu Glu Ser Ser Ser Leu 
65                  70                  75                  80  


Leu Glu Pro Ser Glu Met Gly Arg Gly Xaa Pro Leu Arg Leu Gly Phe 
                85                  90                  95      


Val Ala Gly Val Ile Asn Arg Glu Arg Ile Pro Xaa Phe Glu Arg Met 
            100                 105                 110         


Leu Trp Arg Val Cys Arg Gly Asn Val Phe Leu Arg Gln Ala Glu Ile 
        115                 120                 125             


Glu Asn Pro Leu Glu Asp Pro Val Xaa Val Glu Ser His Ser Val Val 
    130                 135                 140                 


Gln Ala Arg Val Gln Trp Arg Asp Leu Gly Ser Pro Gln Pro Pro Leu 
145                 150                 155                 160 


Pro Gly Phe Lys Arg Phe Ser Cys Leu Ser Leu Pro Ser Ser Trp Gly 
                165                 170                 175     


Leu Gln Gly Asp Tyr Val His Lys Ser Val Phe Ile Ile Phe Phe Gln 
            180                 185                 190         


Gly Asp Gln 
        195 


<210> 3599
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<400> 3599
Ala Tyr Asp Ala His Xaa Ser Glu Asn Ala Pro Ser Leu Leu Ile His 
1               5                   10                  15      


Phe Ile Asn Met Phe Leu Phe Ser Tyr Pro Glu Ser Gly Tyr Ser Met 
            20                  25                  30          


Leu Tyr Ser Gly Gln Lys Gly Ile Gln Cys Phe Leu Val Val Val Ala 
        35                  40                  45              


Leu Leu Cys Val Pro Trp Met Leu Leu Phe Lys Pro Leu Val Leu Arg 
    50                  55                  60                  


Arg Gln Tyr Leu Arg Arg Lys His Leu Gly Xaa Leu Asn Phe Gly Gly 
65                  70                  75                  80  


Ile Arg Val Gly Asn Gly Pro Xaa Glu Glu Asp Ala Glu Ile Ile Gln 
                85                  90                  95      


His Asp Gln Leu Ser Xaa His Ser Glu Asp Ala Asp Glu Pro Ser Glu 
            100                 105                 110         


Asp Glu Val Phe Asp Phe Gly Asp Xaa Met Val His Gln Ala Ile His 
        115                 120                 125             


Xaa Ile Glu Tyr Cys Leu Gly Cys Ile Ser Asn Xaa Ala Ser Tyr Leu 
    130                 135                 140                 


Arg Leu Trp Ala Leu Ser Leu Ala His Ala Arg Leu Ser Ser Arg Ile 
145                 150                 155                 160 


Asn Ser Xaa Ala Gly Pro Val Ser Ser Ser Tyr Pro Ser Pro Ser Ser 
                165                 170                 175     


Ile Phe Gly Lys Gly Ser Leu Lys Ser Glu Ser Leu 
            180                 185             


<210> 3600
<211> 198
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<400> 3600
Met Gly Glu Leu Phe Arg Ser Glu Glu Met Xaa Leu Ala Gln Leu Phe 
1               5                   10                  15      


Leu Gln Ser Glu Ala Ala Tyr Cys Cys Val Ser Glu Leu Gly Glu Leu 
            20                  25                  30          


Gly Lys Val Gln Phe Arg Asp Ala Asn Phe Glu Lys Ile Glu Asn Glu 
        35                  40                  45              


Leu Lys Glu Ile Asn Xaa Asn Gln Glu Ala Leu Lys Arg Asn Phe Leu 
    50                  55                  60                  


Glu Leu Xaa Glu Leu Lys Phe Ile Leu Arg Lys Xaa Gln Gln Phe Phe 
65                  70                  75                  80  


Asp Glu Met Ala Asp Pro Asp Leu Leu Glu Glu Ser Ser Ser Leu Leu 
                85                  90                  95      


Glu Pro Ser Glu Met Gly Arg Gly Xaa Pro Leu Arg Leu Gly Phe Val 
            100                 105                 110         


Ala Gly Val Ile Asn Arg Glu Arg Ile Pro Xaa Phe Glu Arg Met Leu 
        115                 120                 125             


Trp Arg Val Cys Arg Gly Asn Val Phe Leu Arg Gln Ala Glu Ile Glu 
    130                 135                 140                 


Asn Pro Leu Glu Asp Pro Val Xaa Gly Asp Tyr Val His Lys Ser Val 
145                 150                 155                 160 


Phe Ile Ile Phe Phe Gln Gly Asp Gln Leu Lys Asn Arg Val Lys Lys 
                165                 170                 175     


Ile Cys Glu Gly Phe Arg Ala Ser Leu Tyr Pro Cys Pro Glu Xaa Pro 
            180                 185                 190         


Gln Glu Arg Lys Glu Met 
        195             


<210> 3601
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<400> 3601
Met Gly Glu Leu Phe Arg Ser Glu Glu Met Xaa Leu Ala Gln Leu Phe 
1               5                   10                  15      


Leu Gln Ser Glu Ala Ala Tyr Cys Cys Val Ser Glu Leu Gly Glu Leu 
            20                  25                  30          


Gly Lys Val Gln Phe Arg Asp Leu Asn Pro Asp Val Asn Val Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Glu Met Asp Arg Lys 
    50                  55                  60                  


Leu Arg Phe Val Glu Lys Glu Ile Arg Lys Ala Asn Ile Pro Ile Met 
65                  70                  75                  80  


Asp Xaa Gly Glu Asn Pro Glu Val Pro Phe Pro Arg Asp 
                85                  90              


<210> 3602
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<400> 3602
Met Gly Glu Leu Phe Arg Ser Glu Glu Met Xaa Leu Ala Gln Leu Phe 
1               5                   10                  15      


Leu Gln Ser Glu Ala Ala Tyr Cys Cys Val Ser Glu Leu Gly Glu Leu 
            20                  25                  30          


Gly Lys Val Gln Phe Arg Asp Leu Asn Pro Asp Val Asn Val Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Glu Met Asp Arg Lys 
    50                  55                  60                  


Leu Arg Phe Val Glu Lys Glu Ile Arg Lys Ala Asn Ile Pro Ile Met 
65                  70                  75                  80  


Asp Xaa Gly Glu Asn Pro Glu Val Pro Phe Pro Arg Asp Met Ile Asp 
                85                  90                  95      


Leu Glu Ala Asn Phe Glu Lys Ile Glu Asn Glu Leu Lys Glu Ile Asn 
            100                 105                 110         


Xaa Asn Gln Glu Ala Leu Lys Arg Asn Phe Leu Glu Leu Xaa Glu Leu 
        115                 120                 125             


Lys Phe 
    130 


<210> 3603
<211> 838
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<400> 3603
Met Gly Glu Leu Phe Arg Ser Glu Glu Met Xaa Leu Ala Gln Leu Phe 
1               5                   10                  15      


Leu Gln Ser Glu Ala Ala Tyr Cys Cys Val Ser Glu Leu Gly Glu Leu 
            20                  25                  30          


Gly Lys Val Gln Phe Arg Asp Leu Asn Pro Asp Val Asn Val Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Glu Met Asp Arg Lys 
    50                  55                  60                  


Leu Arg Phe Val Glu Lys Glu Ile Arg Lys Ala Asn Ile Pro Ile Met 
65                  70                  75                  80  


Asp Xaa Gly Glu Asn Pro Glu Val Pro Phe Pro Arg Asp Met Ile Asp 
                85                  90                  95      


Leu Glu Ala Asn Phe Glu Lys Ile Glu Asn Glu Leu Lys Glu Ile Asn 
            100                 105                 110         


Xaa Asn Gln Glu Ala Leu Lys Arg Asn Phe Leu Glu Leu Xaa Glu Leu 
        115                 120                 125             


Lys Phe Ile Leu Arg Lys Xaa Gln Gln Phe Phe Asp Glu Ala Glu Leu 
    130                 135                 140                 


His His Gln Gln Met Ala Asp Pro Asp Leu Leu Glu Glu Ser Ser Ser 
145                 150                 155                 160 


Leu Leu Glu Pro Ser Glu Met Gly Arg Gly Xaa Pro Leu Arg Leu Gly 
                165                 170                 175     


Phe Val Ala Gly Val Ile Asn Arg Glu Arg Ile Pro Xaa Phe Glu Arg 
            180                 185                 190         


Met Leu Trp Arg Val Cys Arg Gly Asn Val Phe Leu Arg Gln Ala Glu 
        195                 200                 205             


Ile Glu Asn Pro Leu Glu Asp Pro Val Xaa Gly Asp Tyr Val His Lys 
    210                 215                 220                 


Ser Val Phe Ile Ile Phe Phe Gln Gly Asp Gln Leu Lys Asn Arg Val 
225                 230                 235                 240 


Lys Lys Ile Cys Glu Gly Phe Arg Ala Ser Leu Tyr Pro Cys Pro Glu 
                245                 250                 255     


Xaa Pro Gln Glu Arg Lys Glu Met Ala Ser Gly Val Asn Xaa Arg Ile 
            260                 265                 270         


Asp Asp Leu Gln Met Val Leu Asn Gln Xaa Glu Asp His Arg Gln Arg 
        275                 280                 285             


Val Leu Gln Ala Ala Ala Lys Asn Ile Arg Val Trp Phe Ile Lys Val 
    290                 295                 300                 


Arg Lys Met Lys Ala Ile Tyr His Xaa Leu Asn Leu Cys Asn Ile Asp 
305                 310                 315                 320 


Val Xaa Gln Lys Cys Leu Ile Ala Glu Val Trp Cys Pro Val Xaa Asp 
                325                 330                 335     


Leu Asp Ser Ile Gln Phe Ala Leu Arg Arg Gly Xaa Glu His Ser Gly 
            340                 345                 350         


Ser Xaa Val Pro Ser Ile Leu Asn Arg Met Gln Xaa Asn Gln Xaa Pro 
        355                 360                 365             


Pro Xaa Tyr Asn Lys Xaa Asn Lys Phe Xaa Tyr Gly Phe Gln Asn Ile 
    370                 375                 380                 


Val Asp Ala Tyr Gly Ile Gly Xaa Tyr Arg Glu Ile Asn Pro Ala Pro 
385                 390                 395                 400 


Tyr Xaa Ile Ile Xaa Phe Pro Phe Leu Phe Ala Val Met Phe Gly Asp 
                405                 410                 415     


Phe Gly His Gly Ile Leu Met Xaa Leu Phe Ala Val Trp Met Val Leu 
            420                 425                 430         


Arg Glu Ser Arg Ile Leu Ser Gln Lys Asn Glu Asn Glu Met Phe Ser 
        435                 440                 445             


Xaa Val Phe Ser Gly Arg Tyr Ile Ile Leu Leu Met Gly Val Phe Ser 
    450                 455                 460                 


Met Tyr Xaa Gly Leu Ile Tyr Asn Asp Cys Phe Ser Lys Ser Leu Asn 
465                 470                 475                 480 


Ile Phe Gly Ser Ser Trp Ser Val Arg Pro Met Phe Xaa Tyr Asn Trp 
                485                 490                 495     


Xaa Glu Glu Xaa Leu Arg Gly Asn Pro Val Leu Gln Leu Asn Pro Ala 
            500                 505                 510         


Leu Pro Gly Val Phe Gly Gly Pro Tyr Pro Phe Gly Ile Asp Pro Ile 
        515                 520                 525             


Trp Asn Ile Ala Xaa Asn Lys Leu Xaa Phe Leu Asn Ser Phe Lys Met 
    530                 535                 540                 


Lys Met Ser Val Ile Leu Gly Ile Ile His Met Leu Phe Gly Val Ser 
545                 550                 555                 560 


Leu Ser Leu Phe Asn His Ile Tyr Phe Lys Lys Pro Leu Asn Ile Tyr 
                565                 570                 575     


Phe Gly Phe Ile Pro Glu Ile Ile Phe Met Xaa Ser Leu Phe Gly Tyr 
            580                 585                 590         


Leu Val Ile Leu Ile Phe Tyr Lys Trp Xaa Ala Tyr Asp Ala His Xaa 
        595                 600                 605             


Ser Glu Asn Ala Pro Ser Leu Leu Ile His Phe Ile Asn Met Phe Leu 
    610                 615                 620                 


Phe Ser Tyr Pro Glu Ser Gly Tyr Ser Met Leu Tyr Ser Gly Gln Lys 
625                 630                 635                 640 


Gly Ile Gln Cys Phe Leu Val Val Val Ala Leu Leu Cys Val Pro Trp 
                645                 650                 655     


Met Leu Leu Phe Lys Pro Leu Val Leu Arg Arg Gln Tyr Leu Arg Arg 
            660                 665                 670         


Lys His Leu Gly Xaa Leu Asn Phe Gly Gly Ile Arg Val Gly Asn Gly 
        675                 680                 685             


Pro Xaa Glu Glu Asp Ala Glu Ile Ile Gln His Asp Gln Leu Ser Xaa 
    690                 695                 700                 


His Ser Glu Asp Ala Asp Glu Phe Asp Phe Gly Asp Xaa Met Val His 
705                 710                 715                 720 


Gln Ala Ile His Xaa Ile Glu Tyr Cys Leu Gly Cys Ile Ser Asn Xaa 
                725                 730                 735     


Ala Ser Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala Gln Leu 
            740                 745                 750         


Ser Glu Val Leu Trp Xaa Met Val Ile His Ile Gly Leu Ser Val Lys 
        755                 760                 765             


Ser Leu Ala Gly Gly Leu Val Leu Phe Phe Phe Phe Xaa Ala Phe Ala 
    770                 775                 780                 


Xaa Leu Xaa Val Ala Ile Leu Leu Ile Met Glu Gly Leu Ser Ala Phe 
785                 790                 795                 800 


Leu His Ala Leu Arg Leu His Trp Val Glu Phe Gln Asn Lys Phe Tyr 
                805                 810                 815     


Ser Gly Xaa Gly Phe Lys Phe Leu Pro Phe Ser Phe Glu His Ile Arg 
            820                 825                 830         


Glu Gly Lys Phe Glu Glu 
        835             


<210> 3604
<211> 831
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<400> 3604
Met Gly Glu Leu Phe Arg Ser Glu Glu Met Xaa Leu Ala Gln Leu Phe 
1               5                   10                  15      


Leu Gln Ser Glu Ala Ala Tyr Cys Cys Val Ser Glu Leu Gly Glu Leu 
            20                  25                  30          


Gly Lys Val Gln Phe Arg Asp Leu Asn Pro Asp Val Asn Val Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Glu Met Asp Arg Lys 
    50                  55                  60                  


Leu Arg Phe Val Glu Lys Glu Ile Arg Lys Ala Asn Ile Pro Ile Met 
65                  70                  75                  80  


Asp Xaa Gly Glu Asn Pro Glu Val Pro Phe Pro Arg Asp Met Ile Asp 
                85                  90                  95      


Leu Glu Ala Asn Phe Glu Lys Ile Glu Asn Glu Leu Lys Glu Ile Asn 
            100                 105                 110         


Xaa Asn Gln Glu Ala Leu Lys Arg Asn Phe Leu Glu Leu Xaa Glu Leu 
        115                 120                 125             


Lys Phe Ile Leu Arg Lys Xaa Gln Gln Phe Phe Asp Glu Met Ala Asp 
    130                 135                 140                 


Pro Asp Leu Leu Glu Glu Ser Ser Ser Leu Leu Glu Pro Ser Glu Met 
145                 150                 155                 160 


Gly Arg Gly Xaa Pro Leu Arg Leu Gly Phe Val Ala Gly Val Ile Asn 
                165                 170                 175     


Arg Glu Arg Ile Pro Xaa Phe Glu Arg Met Leu Trp Arg Val Cys Arg 
            180                 185                 190         


Gly Asn Val Phe Leu Arg Gln Ala Glu Ile Glu Asn Pro Leu Glu Asp 
        195                 200                 205             


Pro Val Xaa Gly Asp Tyr Val His Lys Ser Val Phe Ile Ile Phe Phe 
    210                 215                 220                 


Gln Gly Asp Gln Leu Lys Asn Arg Val Lys Lys Ile Cys Glu Gly Phe 
225                 230                 235                 240 


Arg Ala Ser Leu Tyr Pro Cys Pro Glu Xaa Pro Gln Glu Arg Lys Glu 
                245                 250                 255     


Met Ala Ser Gly Val Asn Xaa Arg Ile Asp Asp Leu Gln Met Val Leu 
            260                 265                 270         


Asn Gln Xaa Glu Asp His Arg Gln Arg Val Leu Gln Ala Ala Ala Lys 
        275                 280                 285             


Asn Ile Arg Val Trp Phe Ile Lys Val Arg Lys Met Lys Ala Ile Tyr 
    290                 295                 300                 


His Xaa Leu Asn Leu Cys Asn Ile Asp Val Xaa Gln Lys Cys Leu Ile 
305                 310                 315                 320 


Ala Glu Val Trp Cys Pro Val Xaa Asp Leu Asp Ser Ile Gln Phe Ala 
                325                 330                 335     


Leu Arg Arg Gly Xaa Glu His Ser Gly Ser Xaa Val Pro Ser Ile Leu 
            340                 345                 350         


Asn Arg Met Gln Xaa Asn Gln Xaa Pro Pro Xaa Tyr Asn Lys Xaa Asn 
        355                 360                 365             


Lys Phe Xaa Tyr Gly Phe Gln Asn Ile Val Asp Ala Tyr Gly Ile Gly 
    370                 375                 380                 


Xaa Tyr Arg Glu Ile Asn Pro Ala Pro Tyr Xaa Ile Ile Xaa Phe Pro 
385                 390                 395                 400 


Phe Leu Phe Ala Val Met Phe Gly Asp Phe Gly His Gly Ile Leu Met 
                405                 410                 415     


Xaa Leu Phe Ala Val Trp Met Val Leu Arg Glu Ser Arg Ile Leu Ser 
            420                 425                 430         


Gln Lys Asn Glu Asn Glu Met Phe Ser Xaa Val Phe Ser Gly Arg Tyr 
        435                 440                 445             


Ile Ile Leu Leu Met Gly Val Phe Ser Met Tyr Xaa Gly Leu Ile Tyr 
    450                 455                 460                 


Asn Asp Cys Phe Ser Lys Ser Leu Asn Ile Phe Gly Ser Ser Trp Ser 
465                 470                 475                 480 


Val Arg Pro Met Phe Xaa Tyr Asn Trp Xaa Glu Glu Xaa Leu Arg Gly 
                485                 490                 495     


Asn Pro Val Leu Gln Leu Asn Pro Ala Leu Pro Gly Val Phe Gly Gly 
            500                 505                 510         


Pro Tyr Pro Phe Gly Ile Asp Pro Ile Trp Asn Ile Ala Xaa Asn Lys 
        515                 520                 525             


Leu Xaa Phe Leu Asn Ser Phe Lys Met Lys Met Ser Val Ile Leu Gly 
    530                 535                 540                 


Ile Ile His Met Leu Phe Gly Val Ser Leu Ser Leu Phe Asn His Ile 
545                 550                 555                 560 


Tyr Phe Lys Lys Pro Leu Asn Ile Tyr Phe Gly Phe Ile Pro Glu Ile 
                565                 570                 575     


Ile Phe Met Xaa Ser Leu Phe Gly Tyr Leu Val Ile Leu Ile Phe Tyr 
            580                 585                 590         


Lys Trp Xaa Ala Tyr Asp Ala His Xaa Ser Glu Asn Ala Pro Ser Leu 
        595                 600                 605             


Leu Ile His Phe Ile Asn Met Phe Leu Phe Ser Tyr Pro Glu Ser Gly 
    610                 615                 620                 


Tyr Ser Met Leu Tyr Ser Gly Gln Lys Gly Ile Gln Cys Phe Leu Val 
625                 630                 635                 640 


Val Val Ala Leu Leu Cys Val Pro Trp Met Leu Leu Phe Lys Pro Leu 
                645                 650                 655     


Val Leu Arg Arg Gln Tyr Leu Arg Arg Lys His Leu Gly Xaa Leu Asn 
            660                 665                 670         


Phe Gly Gly Ile Arg Val Gly Asn Gly Pro Xaa Glu Glu Asp Ala Glu 
        675                 680                 685             


Ile Ile Gln His Asp Gln Leu Ser Xaa His Ser Glu Asp Ala Asp Glu 
    690                 695                 700                 


Phe Asp Phe Gly Asp Xaa Met Val His Gln Ala Ile His Xaa Ile Glu 
705                 710                 715                 720 


Tyr Cys Leu Gly Cys Ile Ser Asn Xaa Ala Ser Tyr Leu Arg Leu Trp 
                725                 730                 735     


Ala Leu Ser Leu Ala His Ala Gln Leu Ser Glu Val Leu Trp Xaa Met 
            740                 745                 750         


Val Ile His Ile Gly Leu Ser Val Lys Ser Leu Ala Gly Gly Leu Val 
        755                 760                 765             


Leu Phe Phe Phe Phe Xaa Ala Phe Ala Xaa Leu Xaa Val Ala Ile Leu 
    770                 775                 780                 


Leu Ile Met Glu Gly Leu Ser Ala Phe Leu His Ala Leu Arg Leu His 
785                 790                 795                 800 


Trp Val Glu Phe Gln Asn Lys Phe Tyr Ser Gly Xaa Gly Phe Lys Phe 
                805                 810                 815     


Leu Pro Phe Ser Phe Glu His Ile Arg Glu Gly Lys Phe Glu Glu 
            820                 825                 830     


<210> 3605
<211> 837
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<400> 3605
Met Gly Glu Leu Phe Arg Ser Glu Glu Met Xaa Leu Ala Gln Leu Phe 
1               5                   10                  15      


Leu Gln Ser Glu Ala Ala Tyr Cys Cys Val Ser Glu Leu Gly Glu Leu 
            20                  25                  30          


Gly Lys Val Gln Phe Arg Asp Leu Asn Pro Asp Val Asn Val Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Glu Met Asp Arg Lys 
    50                  55                  60                  


Leu Arg Phe Val Glu Lys Glu Ile Arg Lys Ala Asn Ile Pro Ile Met 
65                  70                  75                  80  


Asp Xaa Gly Glu Asn Pro Glu Val Pro Phe Pro Arg Asp Met Ile Asp 
                85                  90                  95      


Leu Glu Ala Asn Phe Glu Lys Ile Glu Asn Glu Leu Lys Glu Ile Asn 
            100                 105                 110         


Xaa Asn Gln Glu Ala Leu Lys Arg Asn Phe Leu Glu Leu Xaa Glu Leu 
        115                 120                 125             


Lys Phe Ile Leu Arg Lys Xaa Gln Gln Phe Phe Asp Glu Met Ala Asp 
    130                 135                 140                 


Pro Asp Leu Leu Glu Glu Ser Ser Ser Leu Leu Glu Pro Ser Glu Met 
145                 150                 155                 160 


Gly Arg Gly Xaa Pro Leu Arg Leu Gly Phe Val Ala Gly Val Ile Asn 
                165                 170                 175     


Arg Glu Arg Ile Pro Xaa Phe Glu Arg Met Leu Trp Arg Val Cys Arg 
            180                 185                 190         


Gly Asn Val Phe Leu Arg Gln Ala Glu Ile Glu Asn Pro Leu Glu Asp 
        195                 200                 205             


Pro Val Xaa Gly Asp Tyr Val His Lys Ser Val Phe Ile Ile Phe Phe 
    210                 215                 220                 


Gln Gly Asp Gln Leu Lys Asn Arg Val Lys Lys Ile Cys Glu Gly Phe 
225                 230                 235                 240 


Arg Ala Ser Leu Tyr Pro Cys Pro Glu Xaa Pro Gln Glu Arg Lys Glu 
                245                 250                 255     


Met Ala Ser Gly Val Asn Xaa Arg Ile Asp Asp Leu Gln Met Val Leu 
            260                 265                 270         


Asn Gln Xaa Glu Asp His Arg Gln Arg Val Leu Gln Ala Ala Ala Lys 
        275                 280                 285             


Asn Ile Arg Val Trp Phe Ile Lys Val Arg Lys Met Lys Ala Ile Tyr 
    290                 295                 300                 


His Xaa Leu Asn Leu Cys Asn Ile Asp Val Xaa Gln Lys Cys Leu Ile 
305                 310                 315                 320 


Ala Glu Val Trp Cys Pro Val Xaa Asp Leu Asp Ser Ile Gln Phe Ala 
                325                 330                 335     


Leu Arg Arg Gly Xaa Glu His Ser Gly Ser Xaa Val Pro Ser Ile Leu 
            340                 345                 350         


Asn Arg Met Gln Xaa Asn Gln Xaa Pro Pro Xaa Tyr Asn Lys Xaa Asn 
        355                 360                 365             


Lys Phe Xaa Tyr Gly Phe Gln Asn Ile Val Asp Ala Tyr Gly Ile Gly 
    370                 375                 380                 


Xaa Tyr Arg Glu Ile Asn Pro Ala Pro Tyr Xaa Ile Ile Xaa Phe Pro 
385                 390                 395                 400 


Phe Leu Phe Ala Val Met Phe Gly Asp Phe Gly His Gly Ile Leu Met 
                405                 410                 415     


Xaa Leu Phe Ala Val Trp Met Val Leu Arg Glu Ser Arg Ile Leu Ser 
            420                 425                 430         


Gln Lys Asn Glu Asn Glu Met Phe Ser Xaa Val Phe Ser Gly Arg Tyr 
        435                 440                 445             


Ile Ile Leu Leu Met Gly Val Phe Ser Met Tyr Xaa Gly Leu Ile Tyr 
    450                 455                 460                 


Asn Asp Cys Phe Ser Lys Ser Leu Asn Ile Phe Gly Ser Ser Trp Ser 
465                 470                 475                 480 


Val Arg Pro Met Phe Xaa Tyr Asn Trp Xaa Glu Glu Xaa Leu Arg Gly 
                485                 490                 495     


Asn Pro Val Leu Gln Leu Asn Pro Ala Leu Pro Gly Val Phe Gly Gly 
            500                 505                 510         


Pro Tyr Pro Phe Gly Ile Asp Pro Ile Trp Asn Ile Ala Xaa Asn Lys 
        515                 520                 525             


Leu Xaa Phe Leu Asn Ser Phe Lys Met Lys Met Ser Val Ile Leu Gly 
    530                 535                 540                 


Ile Ile His Met Leu Phe Gly Val Ser Leu Ser Leu Phe Asn His Ile 
545                 550                 555                 560 


Tyr Phe Lys Lys Pro Leu Asn Ile Tyr Phe Gly Phe Ile Pro Glu Ile 
                565                 570                 575     


Ile Phe Met Xaa Ser Leu Phe Gly Tyr Leu Val Ile Leu Ile Phe Tyr 
            580                 585                 590         


Lys Trp Xaa Ala Tyr Asp Ala His Xaa Ser Glu Asn Ala Pro Ser Leu 
        595                 600                 605             


Leu Ile His Phe Ile Asn Met Phe Leu Phe Ser Tyr Pro Glu Ser Gly 
    610                 615                 620                 


Tyr Ser Met Leu Tyr Ser Gly Gln Lys Gly Ile Gln Cys Phe Leu Val 
625                 630                 635                 640 


Val Val Ala Leu Leu Cys Val Pro Trp Met Leu Leu Phe Lys Pro Leu 
                645                 650                 655     


Val Leu Arg Arg Gln Tyr Leu Arg Arg Lys His Leu Gly Xaa Leu Asn 
            660                 665                 670         


Phe Gly Gly Ile Arg Val Gly Asn Gly Pro Xaa Glu Glu Asp Ala Glu 
        675                 680                 685             


Ile Ile Gln His Asp Gln Leu Ser Xaa His Ser Glu Asp Ala Asp Glu 
    690                 695                 700                 


Pro Ser Glu Asp Glu Val Phe Asp Phe Gly Asp Xaa Met Val His Gln 
705                 710                 715                 720 


Ala Ile His Xaa Ile Glu Tyr Cys Leu Gly Cys Ile Ser Asn Xaa Ala 
                725                 730                 735     


Ser Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala Gln Leu Ser 
            740                 745                 750         


Glu Val Leu Trp Xaa Met Val Ile His Ile Gly Leu Ser Val Lys Ser 
        755                 760                 765             


Leu Ala Gly Gly Leu Val Leu Phe Phe Phe Phe Xaa Ala Phe Ala Xaa 
    770                 775                 780                 


Leu Xaa Val Ala Ile Leu Leu Ile Met Glu Gly Leu Ser Ala Phe Leu 
785                 790                 795                 800 


His Ala Leu Arg Leu His Trp Val Glu Phe Gln Asn Lys Phe Tyr Ser 
                805                 810                 815     


Gly Xaa Gly Phe Lys Phe Leu Pro Phe Ser Phe Glu His Ile Arg Glu 
            820                 825                 830         


Gly Lys Phe Glu Glu 
        835         


<210> 3606
<211> 788
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<400> 3606
Met Gly Glu Leu Phe Arg Ser Glu Glu Met Xaa Leu Ala Gln Leu Phe 
1               5                   10                  15      


Leu Gln Ser Glu Ala Ala Tyr Cys Cys Val Ser Glu Leu Gly Glu Leu 
            20                  25                  30          


Gly Lys Val Gln Phe Arg Asp Leu Asn Pro Asp Val Asn Val Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Glu Met Asp Arg Lys 
    50                  55                  60                  


Leu Arg Phe Val Glu Lys Glu Ile Arg Lys Ala Asn Ile Pro Ile Met 
65                  70                  75                  80  


Asp Xaa Gly Glu Asn Pro Glu Val Pro Phe Pro Arg Asp Met Ile Asp 
                85                  90                  95      


Leu Glu Met Ala Asp Pro Asp Leu Leu Glu Glu Ser Ser Ser Leu Leu 
            100                 105                 110         


Glu Pro Ser Glu Met Gly Arg Gly Xaa Pro Leu Arg Leu Gly Phe Val 
        115                 120                 125             


Ala Gly Val Ile Asn Arg Glu Arg Ile Pro Xaa Phe Glu Arg Met Leu 
    130                 135                 140                 


Trp Arg Val Cys Arg Gly Asn Val Phe Leu Arg Gln Ala Glu Ile Glu 
145                 150                 155                 160 


Asn Pro Leu Glu Asp Pro Val Xaa Gly Asp Tyr Val His Lys Ser Val 
                165                 170                 175     


Phe Ile Ile Phe Phe Gln Gly Asp Gln Leu Lys Asn Arg Val Lys Lys 
            180                 185                 190         


Ile Cys Glu Gly Phe Arg Ala Ser Leu Tyr Pro Cys Pro Glu Xaa Pro 
        195                 200                 205             


Gln Glu Arg Lys Glu Met Ala Ser Gly Val Asn Xaa Arg Ile Asp Asp 
    210                 215                 220                 


Leu Gln Met Val Leu Asn Gln Xaa Glu Asp His Arg Gln Arg Val Leu 
225                 230                 235                 240 


Gln Ala Ala Ala Lys Asn Ile Arg Val Trp Phe Ile Lys Val Arg Lys 
                245                 250                 255     


Met Lys Ala Ile Tyr His Xaa Leu Asn Leu Cys Asn Ile Asp Val Xaa 
            260                 265                 270         


Gln Lys Cys Leu Ile Ala Glu Val Trp Cys Pro Val Xaa Asp Leu Asp 
        275                 280                 285             


Ser Ile Gln Phe Ala Leu Arg Arg Gly Xaa Glu His Ser Gly Ser Xaa 
    290                 295                 300                 


Val Pro Ser Ile Leu Asn Arg Met Gln Xaa Asn Gln Xaa Pro Pro Xaa 
305                 310                 315                 320 


Tyr Asn Lys Xaa Asn Lys Phe Xaa Tyr Gly Phe Gln Asn Ile Val Asp 
                325                 330                 335     


Ala Tyr Gly Ile Gly Xaa Tyr Arg Glu Ile Asn Pro Ala Pro Tyr Xaa 
            340                 345                 350         


Ile Ile Xaa Phe Pro Phe Leu Phe Ala Val Met Phe Gly Asp Phe Gly 
        355                 360                 365             


His Gly Ile Leu Met Xaa Leu Phe Ala Val Trp Met Val Leu Arg Glu 
    370                 375                 380                 


Ser Arg Ile Leu Ser Gln Lys Asn Glu Asn Glu Met Phe Ser Xaa Val 
385                 390                 395                 400 


Phe Ser Gly Arg Tyr Ile Ile Leu Leu Met Gly Val Phe Ser Met Tyr 
                405                 410                 415     


Xaa Gly Leu Ile Tyr Asn Asp Cys Phe Ser Lys Ser Leu Asn Ile Phe 
            420                 425                 430         


Gly Ser Ser Trp Ser Val Arg Pro Met Phe Xaa Tyr Asn Trp Xaa Glu 
        435                 440                 445             


Glu Xaa Leu Arg Gly Asn Pro Val Leu Gln Leu Asn Pro Ala Leu Pro 
    450                 455                 460                 


Gly Val Phe Gly Gly Pro Tyr Pro Phe Gly Ile Asp Pro Ile Trp Asn 
465                 470                 475                 480 


Ile Ala Xaa Asn Lys Leu Xaa Phe Leu Asn Ser Phe Lys Met Lys Met 
                485                 490                 495     


Ser Val Ile Leu Gly Ile Ile His Met Leu Phe Gly Val Ser Leu Ser 
            500                 505                 510         


Leu Phe Asn His Ile Tyr Phe Lys Lys Pro Leu Asn Ile Tyr Phe Gly 
        515                 520                 525             


Phe Ile Pro Glu Ile Ile Phe Met Xaa Ser Leu Phe Gly Tyr Leu Val 
    530                 535                 540                 


Ile Leu Ile Phe Tyr Lys Trp Xaa Ala Tyr Asp Ala His Xaa Ser Glu 
545                 550                 555                 560 


Asn Ala Pro Ser Leu Leu Ile His Phe Ile Asn Met Phe Leu Phe Ser 
                565                 570                 575     


Tyr Pro Glu Ser Gly Tyr Ser Met Leu Tyr Ser Gly Gln Lys Gly Ile 
            580                 585                 590         


Gln Cys Phe Leu Val Val Val Ala Leu Leu Cys Val Pro Trp Met Leu 
        595                 600                 605             


Leu Phe Lys Pro Leu Val Leu Arg Arg Gln Tyr Leu Arg Arg Lys His 
    610                 615                 620                 


Leu Gly Xaa Leu Asn Phe Gly Gly Ile Arg Val Gly Asn Gly Pro Xaa 
625                 630                 635                 640 


Glu Glu Asp Ala Glu Ile Ile Gln His Asp Gln Leu Ser Xaa His Ser 
                645                 650                 655     


Glu Asp Ala Asp Glu Phe Asp Phe Gly Asp Xaa Met Val His Gln Ala 
            660                 665                 670         


Ile His Xaa Ile Glu Tyr Cys Leu Gly Cys Ile Ser Asn Xaa Ala Ser 
        675                 680                 685             


Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala Gln Leu Ser Glu 
    690                 695                 700                 


Val Leu Trp Xaa Met Val Ile His Ile Gly Leu Ser Val Lys Ser Leu 
705                 710                 715                 720 


Ala Gly Gly Leu Val Leu Phe Phe Phe Phe Xaa Ala Phe Ala Xaa Leu 
                725                 730                 735     


Xaa Val Ala Ile Leu Leu Ile Met Glu Gly Leu Ser Ala Phe Leu His 
            740                 745                 750         


Ala Leu Arg Leu His Trp Val Glu Phe Gln Asn Lys Phe Tyr Ser Gly 
        755                 760                 765             


Xaa Gly Phe Lys Phe Leu Pro Phe Ser Phe Glu His Ile Arg Glu Gly 
    770                 775                 780                 


Lys Phe Glu Glu 
785             


<210> 3607
<211> 794
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<400> 3607
Met Gly Glu Leu Phe Arg Ser Glu Glu Met Xaa Leu Ala Gln Leu Phe 
1               5                   10                  15      


Leu Gln Ser Glu Ala Ala Tyr Cys Cys Val Ser Glu Leu Gly Glu Leu 
            20                  25                  30          


Gly Lys Val Gln Phe Arg Asp Leu Asn Pro Asp Val Asn Val Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Glu Met Asp Arg Lys 
    50                  55                  60                  


Leu Arg Phe Val Glu Lys Glu Ile Arg Lys Ala Asn Ile Pro Ile Met 
65                  70                  75                  80  


Asp Xaa Gly Glu Asn Pro Glu Val Pro Phe Pro Arg Asp Met Ile Asp 
                85                  90                  95      


Leu Glu Met Ala Asp Pro Asp Leu Leu Glu Glu Ser Ser Ser Leu Leu 
            100                 105                 110         


Glu Pro Ser Glu Met Gly Arg Gly Xaa Pro Leu Arg Leu Gly Phe Val 
        115                 120                 125             


Ala Gly Val Ile Asn Arg Glu Arg Ile Pro Xaa Phe Glu Arg Met Leu 
    130                 135                 140                 


Trp Arg Val Cys Arg Gly Asn Val Phe Leu Arg Gln Ala Glu Ile Glu 
145                 150                 155                 160 


Asn Pro Leu Glu Asp Pro Val Xaa Gly Asp Tyr Val His Lys Ser Val 
                165                 170                 175     


Phe Ile Ile Phe Phe Gln Gly Asp Gln Leu Lys Asn Arg Val Lys Lys 
            180                 185                 190         


Ile Cys Glu Gly Phe Arg Ala Ser Leu Tyr Pro Cys Pro Glu Xaa Pro 
        195                 200                 205             


Gln Glu Arg Lys Glu Met Ala Ser Gly Val Asn Xaa Arg Ile Asp Asp 
    210                 215                 220                 


Leu Gln Met Val Leu Asn Gln Xaa Glu Asp His Arg Gln Arg Val Leu 
225                 230                 235                 240 


Gln Ala Ala Ala Lys Asn Ile Arg Val Trp Phe Ile Lys Val Arg Lys 
                245                 250                 255     


Met Lys Ala Ile Tyr His Xaa Leu Asn Leu Cys Asn Ile Asp Val Xaa 
            260                 265                 270         


Gln Lys Cys Leu Ile Ala Glu Val Trp Cys Pro Val Xaa Asp Leu Asp 
        275                 280                 285             


Ser Ile Gln Phe Ala Leu Arg Arg Gly Xaa Glu His Ser Gly Ser Xaa 
    290                 295                 300                 


Val Pro Ser Ile Leu Asn Arg Met Gln Xaa Asn Gln Xaa Pro Pro Xaa 
305                 310                 315                 320 


Tyr Asn Lys Xaa Asn Lys Phe Xaa Tyr Gly Phe Gln Asn Ile Val Asp 
                325                 330                 335     


Ala Tyr Gly Ile Gly Xaa Tyr Arg Glu Ile Asn Pro Ala Pro Tyr Xaa 
            340                 345                 350         


Ile Ile Xaa Phe Pro Phe Leu Phe Ala Val Met Phe Gly Asp Phe Gly 
        355                 360                 365             


His Gly Ile Leu Met Xaa Leu Phe Ala Val Trp Met Val Leu Arg Glu 
    370                 375                 380                 


Ser Arg Ile Leu Ser Gln Lys Asn Glu Asn Glu Met Phe Ser Xaa Val 
385                 390                 395                 400 


Phe Ser Gly Arg Tyr Ile Ile Leu Leu Met Gly Val Phe Ser Met Tyr 
                405                 410                 415     


Xaa Gly Leu Ile Tyr Asn Asp Cys Phe Ser Lys Ser Leu Asn Ile Phe 
            420                 425                 430         


Gly Ser Ser Trp Ser Val Arg Pro Met Phe Xaa Tyr Asn Trp Xaa Glu 
        435                 440                 445             


Glu Xaa Leu Arg Gly Asn Pro Val Leu Gln Leu Asn Pro Ala Leu Pro 
    450                 455                 460                 


Gly Val Phe Gly Gly Pro Tyr Pro Phe Gly Ile Asp Pro Ile Trp Asn 
465                 470                 475                 480 


Ile Ala Xaa Asn Lys Leu Xaa Phe Leu Asn Ser Phe Lys Met Lys Met 
                485                 490                 495     


Ser Val Ile Leu Gly Ile Ile His Met Leu Phe Gly Val Ser Leu Ser 
            500                 505                 510         


Leu Phe Asn His Ile Tyr Phe Lys Lys Pro Leu Asn Ile Tyr Phe Gly 
        515                 520                 525             


Phe Ile Pro Glu Ile Ile Phe Met Xaa Ser Leu Phe Gly Tyr Leu Val 
    530                 535                 540                 


Ile Leu Ile Phe Tyr Lys Trp Xaa Ala Tyr Asp Ala His Xaa Ser Glu 
545                 550                 555                 560 


Asn Ala Pro Ser Leu Leu Ile His Phe Ile Asn Met Phe Leu Phe Ser 
                565                 570                 575     


Tyr Pro Glu Ser Gly Tyr Ser Met Leu Tyr Ser Gly Gln Lys Gly Ile 
            580                 585                 590         


Gln Cys Phe Leu Val Val Val Ala Leu Leu Cys Val Pro Trp Met Leu 
        595                 600                 605             


Leu Phe Lys Pro Leu Val Leu Arg Arg Gln Tyr Leu Arg Arg Lys His 
    610                 615                 620                 


Leu Gly Xaa Leu Asn Phe Gly Gly Ile Arg Val Gly Asn Gly Pro Xaa 
625                 630                 635                 640 


Glu Glu Asp Ala Glu Ile Ile Gln His Asp Gln Leu Ser Xaa His Ser 
                645                 650                 655     


Glu Asp Ala Asp Glu Pro Ser Glu Asp Glu Val Phe Asp Phe Gly Asp 
            660                 665                 670         


Xaa Met Val His Gln Ala Ile His Xaa Ile Glu Tyr Cys Leu Gly Cys 
        675                 680                 685             


Ile Ser Asn Xaa Ala Ser Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala 
    690                 695                 700                 


His Ala Gln Leu Ser Glu Val Leu Trp Xaa Met Val Ile His Ile Gly 
705                 710                 715                 720 


Leu Ser Val Lys Ser Leu Ala Gly Gly Leu Val Leu Phe Phe Phe Phe 
                725                 730                 735     


Xaa Ala Phe Ala Xaa Leu Xaa Val Ala Ile Leu Leu Ile Met Glu Gly 
            740                 745                 750         


Leu Ser Ala Phe Leu His Ala Leu Arg Leu His Trp Val Glu Phe Gln 
        755                 760                 765             


Asn Lys Phe Tyr Ser Gly Xaa Gly Phe Lys Phe Leu Pro Phe Ser Phe 
    770                 775                 780                 


Glu His Ile Arg Glu Gly Lys Phe Glu Glu 
785                 790                 


<210> 3608
<211> 68
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<400> 3608
Met Gly Glu Leu Phe Arg Ser Glu Glu Met Xaa Leu Ala Gln Leu Phe 
1               5                   10                  15      


Leu Gln Ser Glu Ala Ala Tyr Cys Cys Val Ser Glu Leu Gly Glu Leu 
            20                  25                  30          


Gly Lys Val Gln Phe Arg Asp Leu Asn Pro Asp Val Asn Val Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Glu Met Asp Arg Lys 
    50                  55                  60                  


Leu Arg Gln Phe 
65              


<210> 3609
<211> 483
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<400> 3609
Met Gln Xaa Asn Gln Xaa Pro Pro Xaa Tyr Asn Lys Xaa Asn Lys Phe 
1               5                   10                  15      


Xaa Tyr Gly Phe Gln Asn Ile Val Asp Ala Tyr Gly Ile Gly Xaa Tyr 
            20                  25                  30          


Arg Glu Ile Asn Pro Ala Pro Tyr Xaa Ile Ile Xaa Phe Pro Phe Leu 
        35                  40                  45              


Phe Ala Val Met Phe Gly Asp Phe Gly His Gly Ile Leu Met Xaa Leu 
    50                  55                  60                  


Phe Ala Val Trp Met Val Leu Arg Glu Ser Arg Ile Leu Ser Gln Lys 
65                  70                  75                  80  


Asn Glu Asn Glu Met Phe Ser Xaa Val Phe Ser Gly Arg Tyr Ile Ile 
                85                  90                  95      


Leu Leu Met Gly Val Phe Ser Met Tyr Xaa Gly Leu Ile Tyr Asn Asp 
            100                 105                 110         


Cys Phe Ser Lys Ser Leu Asn Ile Phe Gly Ser Ser Trp Ser Val Arg 
        115                 120                 125             


Pro Met Phe Xaa Tyr Asn Trp Xaa Glu Glu Xaa Leu Arg Gly Asn Pro 
    130                 135                 140                 


Val Leu Gln Leu Asn Pro Ala Leu Pro Gly Val Phe Gly Gly Pro Tyr 
145                 150                 155                 160 


Pro Phe Gly Ile Asp Pro Ile Trp Asn Ile Ala Xaa Asn Lys Leu Xaa 
                165                 170                 175     


Phe Leu Asn Ser Phe Lys Met Lys Met Ser Val Ile Leu Gly Ile Ile 
            180                 185                 190         


His Met Leu Phe Gly Val Ser Leu Ser Leu Phe Asn His Ile Tyr Phe 
        195                 200                 205             


Lys Lys Pro Leu Asn Ile Tyr Phe Gly Phe Ile Pro Glu Ile Ile Phe 
    210                 215                 220                 


Met Xaa Ser Leu Phe Gly Tyr Leu Val Ile Leu Ile Phe Tyr Lys Trp 
225                 230                 235                 240 


Xaa Ala Tyr Asp Ala His Xaa Ser Glu Asn Ala Pro Ser Leu Leu Ile 
                245                 250                 255     


His Phe Ile Asn Met Phe Leu Phe Ser Tyr Pro Glu Ser Gly Tyr Ser 
            260                 265                 270         


Met Leu Tyr Ser Gly Gln Lys Gly Ile Gln Cys Phe Leu Val Val Val 
        275                 280                 285             


Ala Leu Leu Cys Val Pro Trp Met Leu Leu Phe Lys Pro Leu Val Leu 
    290                 295                 300                 


Arg Arg Gln Tyr Leu Arg Arg Lys His Leu Gly Xaa Leu Asn Phe Gly 
305                 310                 315                 320 


Gly Ile Arg Val Gly Asn Gly Pro Xaa Glu Glu Asp Ala Glu Ile Ile 
                325                 330                 335     


Gln His Asp Gln Leu Ser Xaa His Ser Glu Asp Ala Asp Glu Pro Ser 
            340                 345                 350         


Glu Asp Glu Val Phe Asp Phe Gly Asp Xaa Met Val His Gln Ala Ile 
        355                 360                 365             


His Xaa Ile Glu Tyr Cys Leu Gly Cys Ile Ser Asn Xaa Ala Ser Tyr 
    370                 375                 380                 


Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala Gln Leu Ser Glu Val 
385                 390                 395                 400 


Leu Trp Xaa Met Val Ile His Ile Gly Leu Ser Val Lys Ser Leu Ala 
                405                 410                 415     


Gly Gly Leu Val Leu Phe Phe Phe Phe Xaa Ala Phe Ala Xaa Leu Xaa 
            420                 425                 430         


Val Ala Ile Leu Leu Ile Met Glu Gly Leu Ser Ala Phe Leu His Ala 
        435                 440                 445             


Leu Arg Leu His Trp Val Glu Phe Gln Asn Lys Phe Tyr Ser Gly Xaa 
    450                 455                 460                 


Gly Phe Lys Phe Leu Pro Phe Ser Phe Glu His Ile Arg Glu Gly Lys 
465                 470                 475                 480 


Phe Glu Glu 
            


<210> 3610
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<400> 3610
Pro Trp Met Leu Leu Phe Lys Pro Leu Val Leu Arg Arg Gln Tyr Leu 
1               5                   10                  15      


Arg Arg Lys His Leu Glu Gly Gln Pro Val Glu Ala Pro Val Ser Pro 
            20                  25                  30          


Asn Pro Ser Gln Gln Gly Leu Glu Ala Ala Ala Ala Ala Xaa Gly Xaa 
        35                  40                  45              


Leu Asn Phe Gly Gly Ile Arg Val Gly Asn Gly Pro Xaa Glu Glu Asp 
    50                  55                  60                  


Ala Glu Ile Ile Gln His Asp Gln Leu Ser Xaa His Ser Glu Asp Ala 
65                  70                  75                  80  


Asp Glu Pro Ser Glu Asp Glu Val Phe Asp Phe Gly Asp Xaa Met Val 
                85                  90                  95      


His Gln Ala Ile His Xaa Ile Glu Tyr Cys Leu Gly Cys Ile Ser Asn 
            100                 105                 110         


Xaa Ala Ser Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala Gln 
        115                 120                 125             


Leu Ser Glu Val Leu Trp Xaa Met Val Ile His Ile Gly Leu Ser Val 
    130                 135                 140                 


Lys Ser Leu Ala Gly Gly Leu Val Leu Phe Phe Phe Phe Xaa Ala Phe 
145                 150                 155                 160 


Ala Xaa Leu Xaa Val Ala Ile Leu Leu Ile Met Glu Gly Leu Ser Ala 
                165                 170                 175     


Phe Leu His Ala Leu Arg Leu His Trp Val Glu Phe Gln Asn Lys 
            180                 185                 190     


<210> 3611
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<400> 3611
Xaa Leu Val Ile Leu Ile Phe Tyr Lys Trp Xaa Ala Tyr Asp Ala His 
1               5                   10                  15      


Xaa Ser Glu Asn Ala Pro Ser Leu Leu Ile His Phe Ile Asn Met Phe 
            20                  25                  30          


Leu Phe Ser Tyr Pro Glu Ser Gly Tyr Ser Met Leu Tyr Ser Gly Gln 
        35                  40                  45              


Lys Gly Ile Gln Cys Phe Leu Val Val Val Ala Leu Leu Cys Val Pro 
    50                  55                  60                  


Trp Met Leu Leu Phe Lys Pro Leu Val Leu Arg Arg Gln Tyr Leu Arg 
65                  70                  75                  80  


Arg Lys His Leu Gly Xaa Leu Asn Phe Gly Gly Ile Arg Val Gly Asn 
                85                  90                  95      


Gly Pro Xaa Glu Glu Asp Ala Glu Ile Ile Gln His Asp Gln Leu Ser 
            100                 105                 110         


Xaa His Ser Glu Asp Ala Asp Glu Ala Leu Ala Pro Ala Gln Trp Lys 
        115                 120                 125             


His 
    


<210> 3612
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 3612
Met Ala Cys Glu Glu Phe Asn Phe Gly Glu Ile Leu Met Xaa Gln Val 
1               5                   10                  15      


Ile His Ser Ile Glu Tyr Cys Leu Gly Cys Ile Ser Asn Xaa Ala Ser 
            20                  25                  30          


Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala Gln Leu Ser Asp 
        35                  40                  45              


Val Leu Trp Ala Met Leu Met Arg Val Gly Leu Arg Val Asp Xaa Xaa 
    50                  55                  60                  


Tyr Gly Val Leu Leu Leu Leu Pro Val Ile Ala Leu Phe Ala Val Leu 
65                  70                  75                  80  


Xaa Ile Phe Ile Leu Leu Ile Met Glu Gly Leu Ser Ala Phe Leu His 
                85                  90                  95      


Ala Ile Arg Leu His Trp Val Glu Phe Gln Asn Lys Phe Tyr Val Gly 
            100                 105                 110         


Ala Gly Xaa Lys Phe Val Pro Phe Ser Phe Ser Leu Leu Ser Ser Lys 
        115                 120                 125             


Phe Asn Asn 
    130     


<210> 3613
<211> 372
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<400> 3613
Met Gly Ser Leu Phe Arg Ser Glu Xaa Met Cys Leu Ala Gln Leu Phe 
1               5                   10                  15      


Leu Gln Ser Gly Xaa Ala Tyr Glu Cys Leu Ser Ala Leu Gly Glu Lys 
            20                  25                  30          


Gly Leu Val Gln Phe Arg Asp Leu Asn Gln Asn Val Ser Ser Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Gly Glu Val Lys Arg Cys Glu Glu Leu Glu Arg Ile 
    50                  55                  60                  


Leu Val Tyr Leu Val Gln Glu Ile Asn Arg Ala Asp Ile Pro Leu Pro 
65                  70                  75                  80  


Glu Gly Glu Ala Ser Pro Pro Ala Pro Pro Leu Lys Gln Val Leu Glu 
                85                  90                  95      


Met Gln Glu Gln Leu Gln Lys Leu Glu Val Glu Leu Arg Glu Val Xaa 
            100                 105                 110         


Lys Asn Lys Glu Lys Leu Arg Lys Asn Leu Leu Glu Leu Ile Glu Tyr 
        115                 120                 125             


Xaa His Met Leu Arg Val Xaa Lys Xaa Phe Val Lys Arg Asn Val Glu 
    130                 135                 140                 


Phe Glu Pro Xaa Tyr Glu Glu Phe Pro Ser Leu Glu Ser Asp Ser Leu 
145                 150                 155                 160 


Leu Asp Tyr Ser Cys Met Gln Arg Leu Gly Ala Lys Leu Gly Phe Val 
                165                 170                 175     


Ser Gly Leu Ile Asn Gln Gly Lys Val Glu Ala Phe Glu Lys Met Leu 
            180                 185                 190         


Trp Arg Val Cys Lys Gly Tyr Xaa Ile Val Ser Tyr Ala Glu Leu Asp 
        195                 200                 205             


Glu Ser Leu Glu Asp Pro Glu Xaa Gly Glu Val Ile Lys Trp Tyr Val 
    210                 215                 220                 


Phe Leu Ile Ser Phe Trp Gly Glu Gln Ile Gly His Lys Val Lys Lys 
225                 230                 235                 240 


Ile Cys Asp Cys Tyr His Cys His Val Tyr Pro Tyr Pro Asn Xaa Ala 
                245                 250                 255     


Glu Glu Arg Arg Glu Ile Gln Glu Gly Leu Asn Xaa Arg Ile Gln Asp 
            260                 265                 270         


Leu Tyr Xaa Val Leu His Lys Xaa Glu Asp Tyr Leu Arg Gln Val Leu 
        275                 280                 285             


Cys Lys Ala Ala Glu Ser Val Tyr Ser Arg Val Ile Gln Val Lys Lys 
    290                 295                 300                 


Met Lys Ala Ile Tyr His Met Leu Asn Met Cys Ser Phe Asp Val Xaa 
305                 310                 315                 320 


Asn Lys Cys Leu Ile Ala Glu Val Trp Cys Pro Glu Ala Asp Leu Gln 
                325                 330                 335     


Asp Leu Arg Arg Ala Leu Glu Glu Gly Ser Val Arg Leu Pro Ser Ser 
            340                 345                 350         


Pro Leu Pro Gly Xaa Glu Glu Arg Leu Met Glu Leu Ile Asn Ser Glu 
        355                 360                 365             


Lys Lys Arg Lys 
    370         


<210> 3614
<211> 856
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<400> 3614
Met Gly Ser Leu Phe Arg Ser Glu Xaa Met Cys Leu Ala Gln Leu Phe 
1               5                   10                  15      


Leu Gln Ser Gly Xaa Ala Tyr Glu Cys Leu Ser Ala Leu Gly Glu Lys 
            20                  25                  30          


Gly Leu Val Gln Phe Arg Asp Leu Asn Gln Asn Val Ser Ser Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Gly Glu Val Lys Arg Cys Glu Glu Leu Glu Arg Ile 
    50                  55                  60                  


Leu Val Tyr Leu Val Gln Glu Ile Asn Arg Ala Asp Ile Pro Leu Pro 
65                  70                  75                  80  


Glu Gly Glu Ala Ser Pro Pro Ala Pro Pro Leu Lys Gln Val Leu Glu 
                85                  90                  95      


Met Gln Glu Gln Leu Gln Lys Leu Glu Val Glu Leu Arg Glu Val Xaa 
            100                 105                 110         


Lys Asn Lys Glu Lys Leu Arg Lys Asn Leu Leu Glu Leu Ile Glu Tyr 
        115                 120                 125             


Xaa His Met Leu Arg Val Xaa Lys Xaa Phe Val Lys Arg Asn Val Glu 
    130                 135                 140                 


Phe Glu Pro Xaa Tyr Glu Glu Phe Pro Ser Leu Glu Ser Asp Ser Leu 
145                 150                 155                 160 


Leu Asp Tyr Ser Cys Met Gln Arg Leu Gly Ala Lys Leu Gly Phe Val 
                165                 170                 175     


Ser Gly Leu Ile Asn Gln Gly Lys Val Glu Ala Phe Glu Lys Met Leu 
            180                 185                 190         


Trp Arg Val Cys Lys Gly Tyr Xaa Ile Val Ser Tyr Ala Glu Leu Asp 
        195                 200                 205             


Glu Ser Leu Glu Asp Pro Glu Xaa Gly Glu Val Ile Lys Trp Tyr Val 
    210                 215                 220                 


Phe Leu Ile Ser Phe Trp Gly Glu Gln Ile Gly His Lys Val Lys Lys 
225                 230                 235                 240 


Ile Cys Asp Cys Tyr His Cys His Val Tyr Pro Tyr Pro Asn Xaa Ala 
                245                 250                 255     


Glu Glu Arg Arg Glu Ile Gln Glu Gly Leu Asn Xaa Arg Ile Gln Asp 
            260                 265                 270         


Leu Tyr Xaa Val Leu His Lys Xaa Glu Asp Tyr Leu Arg Gln Val Leu 
        275                 280                 285             


Cys Lys Ala Ala Glu Ser Val Tyr Ser Arg Val Ile Gln Val Lys Lys 
    290                 295                 300                 


Met Lys Ala Ile Tyr His Met Leu Asn Met Cys Ser Phe Asp Val Xaa 
305                 310                 315                 320 


Asn Lys Cys Leu Ile Ala Glu Val Trp Cys Pro Glu Ala Asp Leu Gln 
                325                 330                 335     


Asp Leu Arg Arg Ala Leu Glu Glu Gly Ser Arg Glu Ser Gly Ala Xaa 
            340                 345                 350         


Ile Pro Ser Phe Met Asn Ile Ile Pro Xaa Lys Glu Xaa Pro Pro Xaa 
        355                 360                 365             


Arg Ile Arg Xaa Asn Lys Phe Xaa Glu Gly Phe Gln Asn Ile Val Asp 
    370                 375                 380                 


Ala Tyr Gly Val Gly Ser Tyr Arg Glu Val Asn Pro Ala Leu Phe Xaa 
385                 390                 395                 400 


Ile Ile Xaa Phe Pro Phe Leu Phe Ala Val Met Phe Gly Asp Phe Gly 
                405                 410                 415     


His Gly Phe Val Met Phe Leu Phe Ala Leu Leu Leu Val Leu Asn Glu 
            420                 425                 430         


Asn His Pro Arg Leu Asn Gln Ser Gln Glu Ile Met Arg Met Phe Phe 
        435                 440                 445             


Asn Gly Arg Tyr Ile Leu Leu Leu Met Gly Leu Phe Ser Val Tyr Xaa 
    450                 455                 460                 


Gly Leu Ile Tyr Asn Asp Cys Phe Ser Lys Ser Val Asn Leu Phe Gly 
465                 470                 475                 480 


Ser Gly Trp Asn Val Ser Ala Met Tyr Ser Ser Ser His Pro Pro Ala 
                485                 490                 495     


Glu His Lys Lys Met Val Leu Trp Asn Asp Ser Val Val Arg His Asn 
            500                 505                 510         


Ser Ile Leu Gln Leu Asp Pro Ser Ile Pro Gly Val Phe Arg Gly Pro 
        515                 520                 525             


Tyr Pro Leu Gly Ile Asp Pro Ile Trp Asn Leu Ala Xaa Asn Arg Leu 
    530                 535                 540                 


Xaa Phe Leu Asn Ser Phe Lys Met Lys Met Ser Val Ile Leu Gly Ile 
545                 550                 555                 560 


Ile His Met Xaa Phe Gly Val Ile Leu Gly Ile Phe Asn His Leu His 
                565                 570                 575     


Phe Arg Lys Lys Phe Asn Ile Tyr Leu Val Ser Ile Pro Glu Leu Leu 
            580                 585                 590         


Phe Met Leu Cys Ile Phe Gly Tyr Leu Ile Phe Met Ile Phe Tyr Lys 
        595                 600                 605             


Trp Leu Val Phe Ser Ala Glu Xaa Ser Arg Val Ala Pro Ser Ile Leu 
    610                 615                 620                 


Ile Glu Phe Ile Asn Met Phe Leu Phe Pro Ala Ser Lys Xaa Ser Gly 
625                 630                 635                 640 


Leu Tyr Xaa Gly Gln Glu Tyr Val Gln Arg Val Leu Leu Val Val Xaa 
                645                 650                 655     


Ala Leu Ser Val Pro Val Leu Phe Leu Gly Lys Pro Leu Phe Leu Leu 
            660                 665                 670         


Trp Leu His Asn Gly Arg Ser Cys Phe Gly Val Asn Arg Ser Gly Tyr 
        675                 680                 685             


Xaa Leu Ile Arg Lys Asp Ser Glu Glu Glu Val Ser Leu Leu Gly Ser 
    690                 695                 700                 


Gln Asp Ile Glu Glu Gly Asn His Gln Val Glu Asp Gly Cys Arg Glu 
705                 710                 715                 720 


Met Ala Cys Glu Glu Phe Asn Phe Gly Glu Ile Leu Met Xaa Gln Val 
                725                 730                 735     


Ile His Ser Ile Glu Tyr Cys Leu Gly Cys Ile Ser Asn Xaa Ala Ser 
            740                 745                 750         


Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala Gln Leu Ser Asp 
        755                 760                 765             


Val Leu Trp Ala Met Leu Met Arg Val Gly Leu Arg Val Asp Xaa Xaa 
    770                 775                 780                 


Tyr Gly Val Leu Leu Leu Leu Pro Val Ile Ala Leu Phe Ala Val Leu 
785                 790                 795                 800 


Xaa Ile Phe Ile Leu Leu Ile Met Glu Gly Leu Ser Ala Phe Leu His 
                805                 810                 815     


Ala Ile Arg Leu His Trp Val Glu Phe Gln Asn Lys Phe Tyr Val Gly 
            820                 825                 830         


Ala Gly Xaa Lys Phe Val Pro Phe Ser Phe Ser Leu Leu Ser Ser Lys 
        835                 840                 845             


Phe Asn Asn Asp Asp Ser Val Ala 
    850                 855     


<210> 3615
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 3615
Met Leu Cys Asp Leu Ser Gln Phe Asn Phe Gly Glu Ile Leu Met Xaa 
1               5                   10                  15      


Gln Val Ile His Ser Ile Glu Tyr Cys Leu Gly Cys Ile Ser Asn Xaa 
            20                  25                  30          


Ala Ser Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala Gln Leu 
        35                  40                  45              


Ser Asp Val Leu Trp Ala Met Leu Met Arg Val Gly Leu Arg Val Asp 
    50                  55                  60                  


Xaa Xaa Tyr Gly Val Leu Leu Leu Leu Pro Val Ile Ala Leu Phe Ala 
65                  70                  75                  80  


Val Leu Xaa Ile Phe Ile Leu Leu Ile Met Glu Gly Leu Ser Ala Phe 
                85                  90                  95      


Leu His Ala Ile Arg Leu His Trp Val Glu Phe Gln Asn Lys Phe Tyr 
            100                 105                 110         


Val Gly Ala Gly Xaa Lys Phe Val Pro Phe Ser Phe Ser Leu Leu Ser 
        115                 120                 125             


Ser Lys Phe Asn Asn Asp Asp Ser Val Ala 
    130                 135             


<210> 3616
<211> 328
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<400> 3616
Met Leu Arg Val Xaa Lys Xaa Phe Val Lys Arg Asn Val Glu Phe Glu 
1               5                   10                  15      


Pro Xaa Tyr Glu Glu Phe Pro Ser Leu Glu Ser Asp Ser Leu Leu Asp 
            20                  25                  30          


Tyr Ser Cys Met Gln Arg Leu Gly Ala Lys Leu Gly Phe Val Ser Gly 
        35                  40                  45              


Leu Ile Asn Gln Gly Lys Val Glu Ala Phe Glu Lys Met Leu Trp Arg 
    50                  55                  60                  


Val Cys Lys Gly Tyr Xaa Ile Val Ser Tyr Ala Glu Leu Asp Glu Ser 
65                  70                  75                  80  


Leu Glu Asp Pro Glu Xaa Gly Glu Val Ile Lys Trp Tyr Val Phe Leu 
                85                  90                  95      


Ile Ser Phe Trp Gly Glu Gln Ile Gly His Lys Val Lys Lys Ile Cys 
            100                 105                 110         


Asp Cys Tyr His Cys His Val Tyr Pro Tyr Pro Asn Xaa Ala Glu Glu 
        115                 120                 125             


Arg Arg Glu Ile Gln Glu Gly Leu Asn Xaa Arg Ile Gln Asp Leu Tyr 
    130                 135                 140                 


Xaa Val Leu His Lys Xaa Glu Asp Tyr Leu Arg Gln Val Leu Cys Lys 
145                 150                 155                 160 


Ala Ala Glu Ser Val Tyr Ser Arg Val Ile Gln Val Lys Lys Met Lys 
                165                 170                 175     


Ala Ile Tyr His Met Leu Asn Met Cys Ser Phe Asp Val Xaa Asn Lys 
            180                 185                 190         


Cys Leu Ile Ala Glu Val Trp Cys Pro Glu Ala Asp Leu Gln Asp Leu 
        195                 200                 205             


Arg Arg Ala Leu Glu Glu Gly Ser Arg Glu Ser Gly Ala Xaa Ile Pro 
    210                 215                 220                 


Ser Phe Met Asn Ile Ile Pro Xaa Lys Glu Xaa Pro Pro Xaa Arg Ile 
225                 230                 235                 240 


Arg Xaa Asn Lys Phe Xaa Glu Gly Phe Gln Asn Ile Val Asp Ala Tyr 
                245                 250                 255     


Gly Val Gly Ser Tyr Arg Glu Val Asn Pro Ala Leu Phe Xaa Ile Ile 
            260                 265                 270         


Xaa Phe Pro Phe Leu Phe Ala Val Met Phe Gly Asp Phe Gly His Gly 
        275                 280                 285             


Phe Val Met Phe Leu Phe Ala Leu Leu Leu Val Leu Asn Glu Asn His 
    290                 295                 300                 


Pro Arg Leu Asn Gln Ser Gln Glu Ile Met Arg Met Phe Phe Asn Gly 
305                 310                 315                 320 


Arg Tyr Ile Leu Leu Leu Met Gly 
                325             


<210> 3617
<211> 840
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<400> 3617
Met Val Ser Val Phe Arg Ser Glu Glu Met Cys Leu Ser Gln Leu Phe 
1               5                   10                  15      


Leu Gln Val Glu Ala Ala Tyr Cys Cys Val Ala Glu Leu Gly Glu Leu 
            20                  25                  30          


Gly Leu Val Gln Phe Lys Asp Leu Asn Met Asn Val Asn Ser Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Ser Leu Glu Arg Ile 
    50                  55                  60                  


Leu Arg Phe Leu Glu Asp Glu Met Gln Asn Glu Ile Val Val Gln Leu 
65                  70                  75                  80  


Leu Glu Lys Ser Pro Leu Xaa Pro Leu Pro Arg Glu Met Ile Xaa Leu 
                85                  90                  95      


Glu Xaa Val Leu Glu Lys Leu Glu Gly Glu Leu Gln Glu Ala Asn Gln 
            100                 105                 110         


Asn Gln Gln Ala Leu Lys Gln Ser Phe Leu Glu Leu Xaa Glu Leu Lys 
        115                 120                 125             


Tyr Leu Leu Lys Lys Xaa Gln Asp Phe Phe Glu Xaa Glu Xaa Asn Leu 
    130                 135                 140                 


Ala Asp Asp Phe Phe Xaa Glu Asp Xaa Ser Gly Leu Leu Glu Leu Lys 
145                 150                 155                 160 


Ala Val Pro Ala Tyr Met Xaa Gly Lys Leu Gly Phe Ile Ala Gly Val 
                165                 170                 175     


Ile Asn Arg Glu Arg Met Ala Ser Phe Glu Arg Leu Leu Trp Arg Ile 
            180                 185                 190         


Cys Arg Gly Asn Val Tyr Leu Lys Phe Ser Glu Met Asp Ala Pro Leu 
        195                 200                 205             


Glu Asp Pro Val Xaa Lys Glu Glu Ile Gln Lys Asn Ile Phe Ile Ile 
    210                 215                 220                 


Phe Tyr Gln Gly Glu Gln Leu Arg Gln Lys Ile Lys Lys Ile Cys Asp 
225                 230                 235                 240 


Gly Phe Arg Ala Xaa Val Tyr Pro Cys Pro Glu Pro Ala Val Glu Arg 
                245                 250                 255     


Arg Glu Met Leu Glu Ser Val Asn Val Arg Leu Glu Asp Leu Ile Xaa 
            260                 265                 270         


Val Ile Xaa Gln Xaa Glu Ser His Arg Gln Arg Leu Leu Gln Glu Ala 
        275                 280                 285             


Ala Ala Asn Trp His Ser Trp Leu Ile Lys Val Gln Lys Met Lys Ala 
    290                 295                 300                 


Val Tyr His Ile Leu Asn Met Cys Asn Ile Asp Val Xaa Gln Gln Cys 
305                 310                 315                 320 


Val Ile Ala Glu Ile Trp Phe Pro Val Ala Asp Ala Xaa Arg Ile Lys 
                325                 330                 335     


Arg Ala Leu Glu Gln Gly Met Glu Leu Ser Gly Ser Ser Met Ala Pro 
            340                 345                 350         


Ile Met Xaa Xaa Val Gln Ser Lys Xaa Ala Pro Pro Xaa Phe Asn Arg 
        355                 360                 365             


Xaa Asn Lys Phe Xaa Ala Gly Phe Gln Asn Ile Val Asp Ala Tyr Gly 
    370                 375                 380                 


Val Gly Ser Tyr Arg Glu Ile Asn Pro Ala Pro Tyr Xaa Ile Ile Xaa 
385                 390                 395                 400 


Phe Pro Phe Leu Phe Ala Val Met Phe Gly Asp Cys Gly His Gly Xaa 
                405                 410                 415     


Val Met Leu Leu Ala Ala Leu Trp Met Ile Leu Asn Glu Arg Arg Leu 
            420                 425                 430         


Leu Ser Gln Lys Xaa Asp Asn Glu Ile Trp Asn Xaa Phe Phe His Gly 
        435                 440                 445             


Arg Tyr Leu Ile Leu Leu Met Gly Ile Phe Ser Ile Tyr Xaa Gly Leu 
    450                 455                 460                 


Ile Tyr Asn Asp Cys Phe Ser Lys Ser Leu Asn Ile Phe Gly Ser Ser 
465                 470                 475                 480 


Trp Ser Val Gln Pro Met Phe Arg Asn Gly Xaa Trp Asn Xaa His Val 
                485                 490                 495     


Met Glu Glu Ser Leu Tyr Leu Gln Leu Asp Pro Ala Ile Pro Gly Val 
            500                 505                 510         


Tyr Phe Gly Asn Pro Tyr Pro Phe Gly Ile Asp Pro Ile Trp Asn Leu 
        515                 520                 525             


Ala Ser Asn Lys Leu Xaa Phe Leu Asn Ser Tyr Lys Met Lys Met Ser 
    530                 535                 540                 


Val Ile Leu Gly Ile Val Gln Met Val Phe Gly Val Ile Leu Ser Leu 
545                 550                 555                 560 


Phe Asn His Ile Tyr Phe Arg Arg Xaa Leu Asn Ile Ile Leu Gln Phe 
                565                 570                 575     


Ile Pro Glu Met Ile Phe Ile Leu Cys Leu Phe Gly Tyr Leu Val Phe 
            580                 585                 590         


Met Ile Ile Phe Lys Trp Cys Cys Phe Asp Val His Val Ser Gln His 
        595                 600                 605             


Ala Pro Ser Ile Leu Ile His Phe Ile Asn Met Phe Leu Phe Asn Tyr 
    610                 615                 620                 


Ser Asp Ser Ser Asn Ala Pro Leu Tyr Lys His Gln Gln Glu Val Gln 
625                 630                 635                 640 


Ser Phe Phe Val Val Met Ala Leu Ile Ser Val Pro Trp Met Leu Leu 
                645                 650                 655     


Ile Lys Pro Phe Ile Leu Arg Ala Ser His Arg Lys Ser Gln Leu Gln 
            660                 665                 670         


Ala Ser Arg Ile Gln Glu Asp Ala Xaa Glu Asn Ile Glu Gly Asp Ser 
        675                 680                 685             


Ser Ser Pro Ser Ser Arg Ser Gly Gln Arg Xaa Ser Ala Asp Xaa His 
    690                 695                 700                 


Gly Ala Leu Asp Asp His Gly Glu Glu Phe Asn Phe Gly Asp Val Phe 
705                 710                 715                 720 


Val His Gln Ala Ile His Xaa Ile Glu Tyr Cys Leu Gly Cys Ile Ser 
                725                 730                 735     


Asn Xaa Ala Ser Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala 
            740                 745                 750         


Gln Leu Ser Glu Val Leu Trp Xaa Met Val Met Asn Ser Gly Leu Gln 
        755                 760                 765             


Xaa Arg Gly Trp Gly Gly Ile Val Gly Val Phe Ile Ile Phe Ala Val 
    770                 775                 780                 


Phe Ala Val Leu Xaa Val Ala Ile Leu Leu Ile Met Glu Gly Leu Ser 
785                 790                 795                 800 


Ala Phe Leu His Ala Leu Arg Leu His Trp Val Glu Phe Gln Asn Lys 
                805                 810                 815     


Phe Tyr Val Gly Asp Gly Tyr Lys Phe Ser Pro Phe Ser Phe Lys His 
            820                 825                 830         


Ile Leu Asp Gly Xaa Ala Glu Glu 
        835                 840 


<210> 3618
<211> 46
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<400> 3618
Met Xaa Gly Leu Ala Leu Leu Tyr Ser Gly Val Phe Val Ala Phe Trp 
1               5                   10                  15      


Ala Cys Ala Leu Ala Val Ala Val Leu Ser Pro Gly Gly Ser Leu Arg 
            20                  25                  30          


Xaa Pro Leu Gln Gly Gly Gly Pro Ser Ala Arg Gln Leu Leu 
        35                  40                  45      


<210> 3619
<211> 252
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<400> 3619
Met Xaa Gly Leu Ala Leu Leu Tyr Ser Gly Val Phe Val Ala Phe Trp 
1               5                   10                  15      


Ala Cys Ala Leu Ala Val Gly Glu Ala Gly Ser Trp Arg Ala Gly Ala 
            20                  25                  30          


Ala Ser Arg Pro Ser Trp Pro Gly Arg Asn Ser Ala Gly Lys Trp Pro 
        35                  40                  45              


Ala Gly Asn Xaa Gly Pro Pro Arg Ala Leu His Pro Arg Leu Trp Gly 
    50                  55                  60                  


Leu Ala Pro Ala Arg Ala Ser Asp Ser Asp Lys Gly Asp Pro Asp Phe 
65                  70                  75                  80  


Gln Leu Leu Glu Glu Gly Phe Leu Xaa Glu Xaa Ser Pro Phe Met Trp 
                85                  90                  95      


Ser Asn Leu Gly Ile Gly Leu Ala Ile Ser Leu Ser Val Val Gly Ala 
            100                 105                 110         


Ala Trp Gly Ile Tyr Ile Xaa Gly Ser Ser Ile Ile Gly Gly Gly Val 
        115                 120                 125             


Lys Ala Pro Arg Ile Lys Xaa Lys Asn Leu Val Ser Ile Ile Phe Cys 
    130                 135                 140                 


Glu Ala Val Ala Ile Tyr Gly Ile Ile Met Ala Ile Val Ile Ser Asn 
145                 150                 155                 160 


Met Ala Glu Pro Phe Ser Ala Xaa Asp Pro Lys Ala Ile Gly His Arg 
                165                 170                 175     


Asn Tyr His Ala Gly Tyr Ser Met Phe Gly Ala Gly Leu Xaa Val Gly 
            180                 185                 190         


Leu Ser Asn Leu Phe Cys Gly Val Cys Val Gly Ile Val Gly Ser Gly 
        195                 200                 205             


Ala Ala Leu Ala Asp Ala Gln Asn Pro Ser Leu Phe Val Lys Ile Leu 
    210                 215                 220                 


Ile Val Glu Ile Phe Gly Ser Ala Ile Gly Leu Phe Gly Val Ile Val 
225                 230                 235                 240 


Ala Ile Leu Gln Xaa Ser Arg Val Lys Met Gly Asp 
                245                 250         


<210> 3620
<211> 205
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<400> 3620
Met Xaa Gly Leu Ala Leu Leu Tyr Ser Gly Val Phe Val Ala Phe Trp 
1               5                   10                  15      


Ala Cys Ala Leu Ala Val Gly Val Cys Tyr Xaa Ile Phe Asp Leu Gly 
            20                  25                  30          


Phe Arg Phe Asp Val Ala Trp Phe Leu Xaa Glu Xaa Ser Pro Phe Met 
        35                  40                  45              


Trp Ser Asn Leu Gly Ile Gly Leu Ala Ile Ser Leu Ser Val Val Gly 
    50                  55                  60                  


Ala Ala Trp Gly Ile Tyr Ile Xaa Gly Ser Ser Ile Ile Gly Gly Gly 
65                  70                  75                  80  


Val Lys Ala Pro Arg Ile Lys Xaa Lys Asn Leu Val Ser Ile Ile Phe 
                85                  90                  95      


Cys Glu Ala Val Ala Ile Tyr Gly Ile Ile Met Ala Ile Val Ile Ser 
            100                 105                 110         


Asn Met Ala Glu Pro Phe Ser Ala Xaa Asp Pro Lys Ala Ile Gly His 
        115                 120                 125             


Arg Asn Tyr His Ala Gly Tyr Ser Met Phe Gly Ala Gly Leu Xaa Val 
    130                 135                 140                 


Gly Leu Ser Asn Leu Phe Cys Gly Val Cys Val Gly Ile Val Gly Ser 
145                 150                 155                 160 


Gly Ala Ala Leu Ala Asp Ala Gln Asn Pro Ser Leu Phe Val Lys Ile 
                165                 170                 175     


Leu Ile Val Glu Ile Phe Gly Ser Ala Ile Gly Leu Phe Gly Val Ile 
            180                 185                 190         


Val Ala Ile Leu Gln Xaa Ser Arg Val Lys Met Gly Asp 
        195                 200                 205 


<210> 3621
<211> 261
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<400> 3621
Met Xaa Gly Leu Ala Leu Leu Tyr Ser Gly Val Phe Val Ala Phe Trp 
1               5                   10                  15      


Ala Cys Ala Leu Ala Val Gly Val Cys Tyr Xaa Ile Phe Asp Leu Gly 
            20                  25                  30          


Phe Arg Phe Asp Val Ala Trp Phe Leu Xaa Glu Xaa Ser Pro Phe Met 
        35                  40                  45              


Trp Ser Asn Leu Gly Ile Gly Leu Ala Ile Ser Leu Ser Val Val Gly 
    50                  55                  60                  


Ala Ala Trp Gly Ile Tyr Ile Xaa Gly Ser Ser Ile Ile Gly Gly Gly 
65                  70                  75                  80  


Val Lys Ala Pro Arg Ile Lys Xaa Lys Asn Leu Val Ser Ile Ile Phe 
                85                  90                  95      


Cys Glu Ala Val Ala Ile Tyr Gly Ile Ile Met Ala Ile Val Ile Ser 
            100                 105                 110         


Asn Met Ala Glu Pro Phe Ser Ala Xaa Asp Pro Lys Ala Ile Gly His 
        115                 120                 125             


Arg Asn Tyr His Ala Gly Tyr Ser Met Phe Gly Ala Gly Leu Xaa Val 
    130                 135                 140                 


Gly Leu Ser Asn Leu Phe Cys Gly Val Cys Val Gly Ile Val Gly Ser 
145                 150                 155                 160 


Gly Ala Ala Leu Ala Asp Ala Gln Asn Pro Ser Leu Phe Val Lys Ile 
                165                 170                 175     


Leu Ile Val Glu Ile Phe Gly Ser Ala Ile Gly Leu Phe Gly Val Ile 
            180                 185                 190         


Val Ala Ile Leu Gln Val Met Asn Pro Leu Gly Lys Pro Leu Cys Pro 
        195                 200                 205             


Cys Pro Gln Pro Ser Leu Xaa Leu Leu Leu Glu Lys Leu Lys Cys Ser 
    210                 215                 220                 


Pro Ser Leu Pro Ile Xaa Ile Asp Ser Pro Lys Gln Leu Pro Pro Pro 
225                 230                 235                 240 


His Phe His Leu Leu Val Phe Ser Tyr Arg Gly Ser Leu Phe Leu Ser 
                245                 250                 255     


Leu Ile Trp Cys His 
            260     


<210> 3622
<211> 86
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<400> 3622
Met Trp Ser Asn Leu Gly Ile Gly Leu Ala Ile Ser Leu Ser Val Val 
1               5                   10                  15      


Gly Ala Ala Trp Gly Ile Tyr Ile Xaa Gly Ser Ser Ile Ile Gly Gly 
            20                  25                  30          


Gly Val Lys Ala Pro Arg Ile Lys Xaa Lys Asn Leu Val Ser Ile Ile 
        35                  40                  45              


Phe Cys Glu Ala Val Ala Ile Tyr Gly Ile Ile Met Ala Ile Val Ile 
    50                  55                  60                  


Ser Asn Met Ala Glu Pro Phe Ser Ala Xaa Asp Pro Lys Ala Ile Gly 
65                  70                  75                  80  


His Arg Asn Tyr His Ala 
                85      


<210> 3623
<211> 158
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<400> 3623
Met Trp Ser Asn Leu Gly Ile Gly Leu Ala Ile Ser Leu Ser Val Val 
1               5                   10                  15      


Gly Ala Ala Trp Gly Ile Tyr Ile Xaa Gly Ser Ser Ile Ile Gly Gly 
            20                  25                  30          


Gly Val Lys Ala Pro Arg Ile Lys Xaa Lys Asn Leu Val Ser Ile Ile 
        35                  40                  45              


Phe Cys Glu Ala Val Ala Ile Tyr Gly Ile Ile Met Ala Ile Val Ile 
    50                  55                  60                  


Ser Asn Met Ala Glu Pro Phe Ser Ala Xaa Asp Pro Lys Ala Ile Gly 
65                  70                  75                  80  


His Arg Asn Tyr His Ala Gly Tyr Ser Met Phe Gly Ala Gly Leu Xaa 
                85                  90                  95      


Val Gly Leu Ser Asn Leu Phe Cys Gly Val Cys Val Gly Ile Val Gly 
            100                 105                 110         


Ser Gly Ala Ala Leu Ala Asp Ala Gln Asn Pro Ser Leu Phe Val Lys 
        115                 120                 125             


Ile Leu Ile Val Glu Ile Phe Gly Ser Ala Ile Gly Leu Phe Gly Val 
    130                 135                 140                 


Ile Val Ala Ile Leu Gln Xaa Ser Arg Val Lys Met Gly Asp 
145                 150                 155             


<210> 3624
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<400> 3624
Xaa Ala Val Gly Glu Ala Gly Ser Trp Arg Ala Gly Ala Ala Ser Arg 
1               5                   10                  15      


Pro Ser Trp Pro Gly Arg Asn Ser Ala Gly Lys Trp Pro Ala Gly Asn 
            20                  25                  30          


Xaa Gly Pro Pro Arg Ala Leu His Pro Arg Leu Trp Gly Leu Ala Pro 
        35                  40                  45              


Ala Arg Ala Ser Asp Ser Asp Lys Gly Asp Pro Asp Phe Gln Leu Leu 
    50                  55                  60                  


Glu Glu Gly Cys Gly Arg Glu Ser Ala Xaa Pro Phe Leu Ile Trp Ala 
65                  70                  75                  80  


Ser Ala Leu Met Trp His Gly Ser 
                85              


<210> 3625
<211> 63
<212> PRT
<213> Homo sapiens

<400> 3625
Met Ser Glu Ser Lys Ser Gly Pro Asp Pro Gly Arg Cys Leu Trp His 
1               5                   10                  15      


Ser Gln Glu Arg Tyr Arg His Cys Gly His Val Cys His Ala Ala Gly 
            20                  25                  30          


Ala Asp His Glu Val His His Pro Ser Gly His Gly Trp His His Arg 
        35                  40                  45              


His Leu Arg Pro Gly Gly Gly Ser Pro His Arg Gln Leu Pro Glu 
    50                  55                  60              


<210> 3626
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<400> 3626
Met Ser Glu Ser Lys Ser Gly Pro Glu Tyr Ala Ser Phe Phe Ala Val 
1               5                   10                  15      


Met Gly Ala Ser Ala Ala Met Val Phe Ser Ala Leu Gly Ala Ala Tyr 
            20                  25                  30          


Gly Xaa Ala Lys Ser Gly Xaa Gly Ile Ala Ala Met Ser Val Met Arg 
        35                  40                  45              


Pro Glu Gln Ile Met Lys Ser Ile Ile Pro Val Val Met Ala Gly Ile 
    50                  55                  60                  


Ile Ala Ile Tyr Gly Leu Val Val Ala Val Leu Ile Ala Asn Ser Leu 
65                  70                  75                  80  


Asn Asp Asp Ile Ser Leu Tyr Lys Ser Phe Leu Gln Leu Gly Ala Gly 
                85                  90                  95      


Leu Ser Val Gly Leu Ser Gly Leu Ala Ala Gly Phe Ala Ile Gly Ile 
            100                 105                 110         


Val Gly Asp Ala Gly Val Arg Gly Xaa Ala Gln Gln Pro Arg Leu Phe 
        115                 120                 125             


Val Gly Met Ile Leu Ile Leu Ile Phe Ala Glu Val Leu Gly Leu Tyr 
    130                 135                 140                 


Gly Leu Ile Val Ala Leu Ile Leu Ser Xaa Lys 
145                 150                 155 


<210> 3627
<211> 112
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 3627
Met Ser Val Met Arg Pro Glu Gln Ile Met Lys Ser Ile Ile Pro Val 
1               5                   10                  15      


Val Met Ala Gly Ile Ile Ala Ile Tyr Gly Leu Val Val Ala Val Leu 
            20                  25                  30          


Ile Ala Asn Ser Leu Asn Asp Asp Ile Ser Leu Tyr Lys Ser Phe Leu 
        35                  40                  45              


Gln Leu Gly Ala Gly Leu Ser Val Gly Leu Ser Gly Leu Ala Ala Gly 
    50                  55                  60                  


Phe Ala Ile Gly Ile Val Gly Asp Ala Gly Val Arg Gly Xaa Ala Gln 
65                  70                  75                  80  


Gln Pro Arg Leu Phe Val Gly Met Ile Leu Ile Leu Ile Phe Ala Glu 
                85                  90                  95      


Val Leu Gly Leu Tyr Gly Leu Ile Val Ala Leu Ile Leu Ser Xaa Lys 
            100                 105                 110         


<210> 3628
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<400> 3628
Met Ser Phe Phe Pro Glu Leu Tyr Phe Asn Val Asp Asn Gly Tyr Leu 
1               5                   10                  15      


Glu Gly Leu Val Arg Gly Leu Lys Ala Gly Val Leu Ser Gln Ala Asp 
            20                  25                  30          


Tyr Leu Asn Leu Val Gln Cys Glu Xaa Leu Glu Asp Leu Lys Leu His 
        35                  40                  45              


Leu Gln Ser Xaa Asp Tyr Gly Asn Phe Leu Ala Asn Glu Ala Ser Pro 
    50                  55                  60                  


Leu Xaa Val Ser Val Ile Asp Asp Arg Leu Lys Glu Lys Met Val Val 
65                  70                  75                  80  


Glu Phe Arg His Met Arg Asn His Ala Tyr Glu Pro Leu Ala Ser Phe 
                85                  90                  95      


Leu Asp Phe Ile Xaa Cys Leu Xaa Leu Xaa Leu Glu Glu Phe Pro Leu 
            100                 105                 110         


Gly Leu Ile 
        115 


<210> 3629
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<400> 3629
Met Ser Phe Phe Pro Glu Leu Tyr Phe Asn Val Asp Asn Gly Tyr Leu 
1               5                   10                  15      


Glu Gly Leu Val Arg Gly Leu Lys Ala Gly Val Leu Ser Gln Ala Asp 
            20                  25                  30          


Tyr Leu Asn Leu Val Gln Cys Glu Xaa Leu Glu Asp Leu Lys Leu His 
        35                  40                  45              


Leu Gln Ser Xaa Asp Tyr Gly Asn Phe Leu Ala Asn Glu Ala Ser Pro 
    50                  55                  60                  


Leu Xaa Val Ser Val Ile Asp Asp Arg Leu Lys Glu Lys Met Val Val 
65                  70                  75                  80  


Glu Phe Arg His Met Arg Asn His Ala Tyr Glu Pro Leu Ala Ser Phe 
                85                  90                  95      


Leu Asp Phe Ile Xaa Gly Phe Phe Pro Gly Leu His Phe Arg Ala Gly 
            100                 105                 110         


Pro 
    


<210> 3630
<211> 392
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<400> 3630
Met Ser Phe Phe Pro Glu Leu Tyr Phe Asn Val Asp Asn Gly Tyr Leu 
1               5                   10                  15      


Glu Gly Leu Val Arg Gly Leu Lys Ala Gly Val Leu Ser Gln Ala Asp 
            20                  25                  30          


Tyr Leu Asn Leu Val Gln Cys Glu Xaa Leu Glu Asp Leu Lys Leu His 
        35                  40                  45              


Leu Gln Ser Xaa Asp Tyr Gly Asn Phe Leu Ala Asn Glu Ala Ser Pro 
    50                  55                  60                  


Leu Xaa Val Ser Val Ile Asp Asp Arg Leu Lys Glu Lys Met Val Val 
65                  70                  75                  80  


Glu Phe Arg His Met Arg Asn His Ala Tyr Glu Pro Leu Ala Ser Phe 
                85                  90                  95      


Leu Asp Phe Ile Xaa Gln Glu Ser Glu Ala Gly Xaa Pro Glu Gly Pro 
            100                 105                 110         


Gly Asn Met Pro Lys Leu Gly Ser Arg Pro Ser Pro Gly His Arg Pro 
        115                 120                 125             


Pro Phe Leu Arg Val Ser Leu Leu Pro Trp Pro Pro Ser Ser Tyr Ser 
    130                 135                 140                 


Tyr Met Ile Asp Asn Val Ile Leu Leu Ile Xaa Gly Xaa Leu His Gln 
145                 150                 155                 160 


Arg Ser Ile Ala Glu Leu Val Pro Lys Cys His Pro Leu Gly Ser Phe 
                165                 170                 175     


Glu Gln Met Glu Ala Val Asn Ile Ala Gln Xaa Pro Ala Glu Leu Tyr 
            180                 185                 190         


Asn Ala Ile Leu Val Asp Xaa Pro Leu Ala Ala Phe Phe Gln Asp Cys 
        195                 200                 205             


Ile Ser Glu Gln Asp Leu Asp Glu Met Asn Ile Glu Ile Ile Arg Asn 
    210                 215                 220                 


Xaa Leu Tyr Lys Ala Tyr Leu Glu Ser Phe Tyr Lys Phe Cys Xaa Leu 
225                 230                 235                 240 


Leu Gly Gly Xaa Xaa Ala Asp Ala Met Cys Pro Ile Leu Glu Phe Glu 
                245                 250                 255     


Ala Asp Arg Arg Ala Phe Ile Ile Xaa Ile Asn Ser Phe Gly Xaa Glu 
            260                 265                 270         


Leu Ser Lys Glu Asp Arg Ala Lys Leu Phe Pro His Cys Gly Arg Leu 
        275                 280                 285             


Tyr Pro Glu Gly Leu Ala Gln Leu Ala Arg Ala Asp Asp Tyr Glu Gln 
    290                 295                 300                 


Val Lys Asn Val Ala Asp Tyr Tyr Pro Glu Tyr Lys Leu Leu Phe Glu 
305                 310                 315                 320 


Gly Ala Gly Ser Asn Pro Gly Asp Lys Xaa Leu Glu Asp Arg Phe Phe 
                325                 330                 335     


Glu His Glu Val Lys Leu Asn Lys Leu Ala Phe Leu Asn Gln Phe His 
            340                 345                 350         


Phe Gly Val Phe Tyr Ala Phe Val Lys Leu Lys Glu Gln Glu Cys Arg 
        355                 360                 365             


Asn Ile Val Trp Ile Ala Glu Cys Ile Ala Gln Arg His Arg Ala Lys 
    370                 375                 380                 


Ile Asp Asn Tyr Ile Pro Ile Phe 
385                 390         


<210> 3631
<211> 351
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<400> 3631
Met Ser Phe Phe Pro Glu Leu Tyr Phe Asn Val Asp Asn Gly Tyr Leu 
1               5                   10                  15      


Glu Gly Leu Val Arg Gly Leu Lys Ala Gly Val Leu Ser Gln Ala Asp 
            20                  25                  30          


Tyr Leu Asn Leu Val Gln Cys Glu Xaa Leu Glu Asp Leu Lys Leu His 
        35                  40                  45              


Leu Gln Ser Xaa Asp Tyr Gly Asn Phe Leu Ala Asn Glu Ala Ser Pro 
    50                  55                  60                  


Leu Xaa Val Ser Val Ile Asp Asp Arg Leu Lys Glu Lys Met Val Val 
65                  70                  75                  80  


Glu Phe Arg His Met Arg Asn His Ala Tyr Glu Pro Leu Ala Ser Phe 
                85                  90                  95      


Leu Asp Phe Ile Xaa Tyr Ser Tyr Met Ile Asp Asn Val Ile Leu Leu 
            100                 105                 110         


Ile Xaa Gly Xaa Leu His Gln Arg Ser Ile Ala Glu Leu Val Pro Lys 
        115                 120                 125             


Cys His Pro Leu Gly Ser Phe Glu Gln Met Glu Ala Val Asn Ile Ala 
    130                 135                 140                 


Gln Xaa Pro Ala Glu Leu Tyr Asn Ala Ile Leu Val Asp Xaa Pro Leu 
145                 150                 155                 160 


Ala Ala Phe Phe Gln Asp Cys Ile Ser Glu Gln Asp Leu Asp Glu Met 
                165                 170                 175     


Asn Ile Glu Ile Ile Arg Asn Xaa Leu Tyr Lys Ala Tyr Leu Glu Ser 
            180                 185                 190         


Phe Tyr Lys Phe Cys Xaa Leu Leu Gly Gly Xaa Xaa Ala Asp Ala Met 
        195                 200                 205             


Cys Pro Ile Leu Glu Phe Glu Ala Asp Arg Arg Ala Phe Ile Ile Xaa 
    210                 215                 220                 


Ile Asn Ser Phe Gly Xaa Glu Leu Ser Lys Glu Asp Arg Ala Lys Leu 
225                 230                 235                 240 


Phe Pro His Cys Gly Arg Leu Tyr Pro Glu Gly Leu Ala Gln Leu Ala 
                245                 250                 255     


Arg Ala Asp Asp Tyr Glu Gln Val Lys Asn Val Ala Asp Tyr Tyr Pro 
            260                 265                 270         


Glu Tyr Lys Leu Leu Phe Glu Gly Ala Gly Ser Asn Pro Gly Asp Lys 
        275                 280                 285             


Xaa Leu Glu Asp Arg Phe Phe Glu His Glu Val Lys Leu Asn Lys Leu 
    290                 295                 300                 


Ala Phe Leu Asn Gln Phe His Phe Gly Val Phe Tyr Ala Phe Val Lys 
305                 310                 315                 320 


Leu Lys Glu Gln Glu Cys Arg Asn Ile Val Trp Ile Ala Glu Cys Ile 
                325                 330                 335     


Ala Gln Arg His Arg Ala Lys Ile Asp Asn Tyr Ile Pro Ile Phe 
            340                 345                 350     


<210> 3632
<211> 57
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<400> 3632
Met Ser Phe Phe Pro Glu Leu Tyr Phe Asn Val Asp Asn Gly Tyr Leu 
1               5                   10                  15      


Glu Gly Leu Val Arg Gly Leu Lys Ala Gly Val Leu Ser Gln Ala Asp 
            20                  25                  30          


Tyr Leu Asn Leu Val Gln Cys Glu Xaa Leu Glu Gly Met Asp Gly Ala 
        35                  40                  45              


Xaa Arg Asp Ala Arg Gly Xaa Cys Pro 
    50                  55          


<210> 3633
<211> 47
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<400> 3633
Met Ser Phe Phe Pro Glu Leu Tyr Phe Asn Val Asp Asn Gly Tyr Leu 
1               5                   10                  15      


Glu Gly Leu Val Arg Gly Leu Lys Ala Gly Val Leu Ser Gln Ala Asp 
            20                  25                  30          


Tyr Leu Asn Leu Val Gln Cys Glu Xaa Leu Glu Val Xaa Val Xaa 
        35                  40                  45          


<210> 3634
<211> 274
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<400> 3634
Met Val Val Glu Phe Arg His Met Arg Asn His Ala Tyr Glu Pro Leu 
1               5                   10                  15      


Ala Ser Phe Leu Asp Phe Ile Xaa Tyr Ser Tyr Met Ile Asp Asn Val 
            20                  25                  30          


Ile Leu Leu Ile Xaa Gly Xaa Leu His Gln Arg Ser Ile Ala Glu Leu 
        35                  40                  45              


Val Pro Lys Cys His Pro Leu Gly Ser Phe Glu Gln Met Glu Ala Val 
    50                  55                  60                  


Asn Ile Ala Gln Xaa Pro Ala Glu Leu Tyr Asn Ala Ile Leu Val Asp 
65                  70                  75                  80  


Xaa Pro Leu Ala Ala Phe Phe Gln Asp Cys Ile Ser Glu Gln Asp Leu 
                85                  90                  95      


Asp Glu Met Asn Ile Glu Ile Ile Arg Asn Xaa Leu Tyr Lys Ala Tyr 
            100                 105                 110         


Leu Glu Ser Phe Tyr Lys Phe Cys Xaa Leu Leu Gly Gly Xaa Xaa Ala 
        115                 120                 125             


Asp Ala Met Cys Pro Ile Leu Glu Phe Glu Ala Asp Arg Arg Ala Phe 
    130                 135                 140                 


Ile Ile Xaa Ile Asn Ser Phe Gly Xaa Glu Leu Ser Lys Glu Asp Arg 
145                 150                 155                 160 


Ala Lys Leu Phe Pro His Cys Gly Arg Leu Tyr Pro Glu Gly Leu Ala 
                165                 170                 175     


Gln Leu Ala Arg Ala Asp Asp Tyr Glu Gln Val Lys Asn Val Ala Asp 
            180                 185                 190         


Tyr Tyr Pro Glu Tyr Lys Leu Leu Phe Glu Gly Ala Gly Ser Asn Pro 
        195                 200                 205             


Gly Asp Lys Xaa Leu Glu Asp Arg Phe Phe Glu His Glu Val Lys Leu 
    210                 215                 220                 


Asn Lys Leu Ala Phe Leu Asn Gln Phe His Phe Gly Val Phe Tyr Ala 
225                 230                 235                 240 


Phe Val Lys Leu Lys Glu Gln Glu Cys Arg Asn Ile Val Trp Ile Ala 
                245                 250                 255     


Glu Cys Ile Ala Gln Arg His Arg Ala Lys Ile Asp Asn Tyr Ile Pro 
            260                 265                 270         


Ile Phe 
        


<210> 3635
<211> 232
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<400> 3635
Xaa Phe Pro Glu Leu Tyr Phe Asn Val Asp Asn Gly Tyr Leu Glu Gly 
1               5                   10                  15      


Leu Val Arg Gly Leu Lys Ala Gly Val Leu Ser Gln Ala Asp Tyr Leu 
            20                  25                  30          


Asn Leu Val Gln Cys Glu Xaa Leu Glu Ala Ala Phe Phe Gln Asp Cys 
        35                  40                  45              


Ile Ser Glu Gln Asp Leu Asp Glu Met Asn Ile Glu Ile Ile Arg Asn 
    50                  55                  60                  


Xaa Leu Tyr Lys Ala Tyr Leu Glu Ser Phe Tyr Lys Phe Cys Xaa Leu 
65                  70                  75                  80  


Leu Gly Gly Xaa Xaa Ala Asp Ala Met Cys Pro Ile Leu Glu Phe Glu 
                85                  90                  95      


Ala Asp Arg Arg Ala Phe Ile Ile Xaa Ile Asn Ser Phe Gly Xaa Glu 
            100                 105                 110         


Leu Ser Lys Glu Asp Arg Ala Lys Leu Phe Pro His Cys Gly Arg Leu 
        115                 120                 125             


Tyr Pro Glu Gly Leu Ala Gln Leu Ala Arg Ala Asp Asp Tyr Glu Gln 
    130                 135                 140                 


Val Lys Asn Val Ala Asp Tyr Tyr Pro Glu Tyr Lys Leu Leu Phe Glu 
145                 150                 155                 160 


Gly Ala Gly Ser Asn Pro Gly Asp Lys Xaa Leu Glu Asp Arg Phe Phe 
                165                 170                 175     


Glu His Glu Val Lys Leu Asn Lys Leu Ala Phe Leu Asn Gln Phe His 
            180                 185                 190         


Phe Gly Val Phe Tyr Ala Phe Val Lys Leu Lys Glu Gln Glu Cys Arg 
        195                 200                 205             


Asn Ile Val Trp Ile Ala Glu Cys Ile Ala Gln Arg His Arg Ala Lys 
    210                 215                 220                 


Ile Asp Asn Tyr Ile Pro Ile Phe 
225                 230         


<210> 3636
<211> 40
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<400> 3636
Xaa His Phe Lys Gly Phe Ser Leu Arg Gln Pro Val Asp Phe Pro Gly 
1               5                   10                  15      


Ala Leu Ala Gly Ala Glu Ile Xaa Gly Arg Ser Leu Trp Pro Ala Ser 
            20                  25                  30          


Ser Xaa Val Arg Pro Val Lys Gly 
        35                  40  


<210> 3637
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<400> 3637
Xaa Leu Glu His Leu Leu Glu Gln Arg Ser Gln Glu Gly His Ser Gly 
1               5                   10                  15      


Gln Gln Val Ala Leu Leu Asp Gln Ser Arg Ala Glu Val Met Leu Gly 
            20                  25                  30          


Leu Arg Ala Arg Gly Leu Xaa Gly Cys Gly Gly Glu Ala Glu Leu Gln 
        35                  40                  45              


Leu Gln Gly Tyr Met Asp Cys Trp Val Lys Val Xaa Ala Asn His Ser 
    50                  55                  60                  


Ile Trp Arg Xaa Ser Phe Trp 
65                  70      


<210> 3638
<211> 227
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<400> 3638
Xaa Leu Lys Leu His Leu Gln Ser Xaa Asp Tyr Gly Asn Phe Leu Ala 
1               5                   10                  15      


Asn Glu Ala Ser Pro Leu Xaa Val Ser Val Ile Asp Asp Arg Leu Lys 
            20                  25                  30          


Glu Lys Met Val Val Glu Phe Arg His Met Arg Asn His Ala Tyr Glu 
        35                  40                  45              


Pro Leu Ala Ser Phe Leu Asp Phe Ile Xaa Tyr Ser Tyr Met Ile Asp 
    50                  55                  60                  


Asn Val Ile Leu Leu Ile Xaa Gly Xaa Leu His Gln Arg Ser Ile Ala 
65                  70                  75                  80  


Glu Leu Val Pro Lys Cys His Pro Leu Gly Ser Phe Glu Gln Met Glu 
                85                  90                  95      


Ala Val Asn Ile Ala Gln Xaa Pro Ala Glu Leu Tyr Asn Ala Ile Leu 
            100                 105                 110         


Val Asp Xaa Pro Leu Ala Ala Phe Phe Gln Asp Cys Ile Ser Glu Gln 
        115                 120                 125             


Asp Leu Asp Glu Met Asn Ile Glu Ile Ile Arg Asn Xaa Leu Tyr Lys 
    130                 135                 140                 


Ala Tyr Leu Glu Ser Phe Tyr Lys Phe Cys Xaa Leu Leu Gly Gly Xaa 
145                 150                 155                 160 


Xaa Ala Asp Ala Met Cys Pro Ile Leu Glu Ser Cys Pro Lys Arg Xaa 
                165                 170                 175     


Val Pro Ser Ser Phe His Xaa Val Gly Gly Ser Xaa Leu Arg Ala Trp 
            180                 185                 190         


Arg Ser Trp Leu Gly Leu Xaa Xaa Met Asn Arg Ser Arg Xaa Trp Pro 
        195                 200                 205             


Ile Xaa Xaa Arg Ser Xaa Ser Cys Ser Ser Arg Val Gln Val Ala Xaa 
    210                 215                 220                 


Leu Glu Xaa 
225         


<210> 3639
<211> 58
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<400> 3639
Xaa Ser Cys Xaa Ser Arg Ala Ser Leu Ser Gly Ser Leu Trp Xaa Ser 
1               5                   10                  15      


Leu Glu His Leu Leu Glu Gln Arg Ser Gln Glu Gly His Ser Gly Gln 
            20                  25                  30          


Gln Val Ala Leu Leu Asp Gln Ser Arg Ala Glu Glu Trp Met Val Pro 
        35                  40                  45              


Gln Gly Met Pro Glu Gly Leu Val Pro Glu 
    50                  55              


<210> 3640
<211> 36
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<400> 3640
Met Leu Glu Gly Ala Glu Leu Tyr Phe Asn Val Asp His Gly Tyr Leu 
1               5                   10                  15      


Glu Gly Leu Val Arg Gly Cys Lys Ala Ser Leu Leu Xaa Gln Gln Asp 
            20                  25                  30          


Tyr Ile Asn Leu 
        35      


<210> 3641
<211> 43
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<400> 3641
Met Leu Glu Gly Ala Glu Leu Tyr Phe Asn Val Asp His Gly Tyr Leu 
1               5                   10                  15      


Glu Gly Leu Val Arg Gly Cys Lys Ala Ser Leu Leu Xaa Gln Gln Asp 
            20                  25                  30          


Tyr Ile Asn Leu Val Gln Cys Glu Xaa Leu Glu 
        35                  40              


<210> 3642
<211> 350
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<400> 3642
Met Leu Glu Gly Ala Glu Leu Tyr Phe Asn Val Asp His Gly Tyr Leu 
1               5                   10                  15      


Glu Gly Leu Val Arg Gly Cys Lys Ala Ser Leu Leu Xaa Gln Gln Asp 
            20                  25                  30          


Tyr Ile Asn Leu Val Gln Cys Glu Xaa Leu Glu Asp Leu Lys Ile His 
        35                  40                  45              


Leu Gln Xaa Xaa Asp Tyr Gly Asn Phe Leu Ala Asn His Xaa Asn Pro 
    50                  55                  60                  


Leu Xaa Val Ser Lys Ile Asp Xaa Glu Met Arg Lys Arg Leu Cys Gly 
65                  70                  75                  80  


Glu Phe Glu Tyr Phe Arg Asn His Ser Leu Glu Pro Leu Ser Xaa Phe 
                85                  90                  95      


Leu Xaa Tyr Met Xaa Cys Ser Tyr Met Ile Asp Asn Val Ile Leu Leu 
            100                 105                 110         


Met Asn Gly Ala Leu Gln Lys Lys Ser Val Lys Glu Ile Leu Gly Lys 
        115                 120                 125             


Cys His Pro Leu Gly Arg Phe Xaa Glu Met Glu Ala Val Asn Ile Ala 
    130                 135                 140                 


Glu Xaa Pro Ser Asp Leu Phe Asn Ala Ile Leu Ile Glu Xaa Pro Leu 
145                 150                 155                 160 


Ala Pro Phe Phe Gln Asp Cys Met Ser Glu Asn Ala Leu Asp Glu Leu 
                165                 170                 175     


Asn Ile Glu Leu Leu Arg Asn Lys Leu Tyr Lys Ser Tyr Leu Glu Ala 
            180                 185                 190         


Phe Tyr Lys Phe Cys Lys Asn His Gly Asp Val Xaa Ala Glu Val Met 
        195                 200                 205             


Cys Pro Ile Leu Glu Phe Glu Ala Asp Arg Arg Ala Phe Ile Ile Xaa 
    210                 215                 220                 


Leu Asn Ser Phe Gly Xaa Glu Leu Ser Lys Glu Asp Arg Glu Xaa Leu 
225                 230                 235                 240 


Tyr Pro Xaa Phe Gly Lys Leu Tyr Pro Glu Gly Leu Arg Leu Leu Ala 
                245                 250                 255     


Gln Ala Glu Asp Phe Asp Gln Met Lys Asn Val Ala Asp His Tyr Gly 
            260                 265                 270         


Val Tyr Lys Pro Leu Phe Glu Ala Val Gly Gly Ser Gly Gly Lys Xaa 
        275                 280                 285             


Leu Glu Asp Val Phe Tyr Glu Arg Glu Val Gln Met Asn Val Leu Ala 
    290                 295                 300                 


Phe Asn Arg Gln Phe His Tyr Gly Val Phe Tyr Ala Tyr Val Lys Leu 
305                 310                 315                 320 


Lys Glu Gln Glu Ile Arg Asn Ile Val Trp Ile Ala Glu Cys Ile Ser 
                325                 330                 335     


Gln Arg His Arg Xaa Lys Ile Asn Ser Tyr Ile Pro Ile Leu 
            340                 345                 350 


<210> 3643
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<400> 3643
Met Ala Tyr His Gly Leu Xaa Val Pro Leu Ile Val Met Ser Val Phe 
1               5                   10                  15      


Trp Gly Phe Val Gly Phe Leu Val Pro Trp Phe Ile Pro Lys Gly Pro 
            20                  25                  30          


Asn Arg Gly Val Ile Ile Xaa Met Leu Val Xaa Cys Ser Val Cys Cys 
        35                  40                  45              


Tyr Leu Phe Trp Leu Ile Ala Ile Leu Ala Gln Leu Asn Pro Leu Phe 
    50                  55                  60                  


Gly Pro Gln Leu Lys Asn Glu Xaa Ile Trp Tyr Leu Lys Tyr His Trp 
65                  70                  75                  80  


Pro 
    


<210> 3644
<211> 58
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<400> 3644
Met Ala Tyr His Gly Leu Xaa Val Pro Leu Ile Val Met Ser Val Phe 
1               5                   10                  15      


Trp Gly Phe Val Gly Phe Leu Val Pro Trp Phe Ile Pro Lys Gly Pro 
            20                  25                  30          


Asn Arg Gly Val Ile Ile Xaa Met Leu Val Xaa Cys Ser Val Cys Cys 
        35                  40                  45              


Tyr Leu Leu Ser Arg Glu Glu Asn Ala Phe 
    50                  55              


<210> 3645
<211> 65
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<400> 3645
Met Ala Tyr His Gly Leu Xaa Val Pro Leu Ile Val Met Ser Val Phe 
1               5                   10                  15      


Trp Gly Phe Val Gly Phe Leu Val Pro Trp Phe Ile Pro Lys Gly Pro 
            20                  25                  30          


Asn Arg Gly Trp Leu Ile Ala Ile Leu Ala Gln Leu Asn Pro Leu Phe 
        35                  40                  45              


Gly Pro Gln Leu Lys Asn Glu Xaa Ile Trp Tyr Leu Lys Tyr His Trp 
    50                  55                  60                  


Pro 
65  


<210> 3646
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<400> 3646
Met Arg Val Arg Gly Pro Ala Arg Leu Ile Ala Ser Gly Ala Arg Leu 
1               5                   10                  15      


Leu Leu Arg Met Leu Ser Ala Leu Pro Gly Trp Gly Pro Ala His Leu 
            20                  25                  30          


Gln Arg Pro Leu Leu Gly Pro Ala Ser Cys Leu Gly Ile Leu Arg Pro 
        35                  40                  45              


Ala Met Xaa Ala His Ser Phe Ala Leu Pro Val Ile Ile Phe Xaa Xaa 
    50                  55                  60                  


Phe Trp Gly Leu Val Gly Ile Ala Gly Pro Trp Phe Val Pro Lys Gly 
65                  70                  75                  80  


Pro Asn Arg Gly Val Ile Ile Xaa Met Leu Val Ala Xaa Ala Val Cys 
                85                  90                  95      


Cys Tyr Leu Phe Trp Leu Ile Ala Ile Leu Ala Gln Leu Asn Pro Leu 
            100                 105                 110         


Phe Gly Pro Gln Leu Lys Asn Glu Xaa Ile Trp Tyr Val Arg Phe Leu 
        115                 120                 125             


Trp Glu 
    130 


<210> 3647
<211> 213
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<400> 3647
Met Arg Val Arg Gly Pro Ala Arg Leu Ile Ala Ser Gly Ala Arg Leu 
1               5                   10                  15      


Leu Leu Arg Met Leu Ser Ala Leu Pro Gly Trp Gly Pro Ala His Leu 
            20                  25                  30          


Gln Arg Pro Leu Leu Gly Pro Ala Ser Cys Leu Gly Ile Leu Arg Pro 
        35                  40                  45              


Ala Met Xaa Ala His Ser Phe Ala Leu Pro Val Ile Ile Phe Xaa Xaa 
    50                  55                  60                  


Phe Trp Gly Leu Val Gly Ile Ala Gly Pro Trp Phe Val Pro Lys Gly 
65                  70                  75                  80  


Pro Asn Arg Gly Val Ile Ile Xaa Met Leu Val Ala Xaa Ala Val Cys 
                85                  90                  95      


Cys Tyr Leu Leu Cys Pro Ala Leu Gly Met Xaa Val Ala Pro Leu Ser 
            100                 105                 110         


Leu Xaa Xaa Pro Ser Ser Gly Pro Ser Pro Xaa Gln Leu Cys Leu Val 
        115                 120                 125             


Xaa Ser Ser Leu Leu Leu Ala Pro Arg Asp Pro Asp Pro Gln Gly Leu 
    130                 135                 140                 


Pro Gly Ser Trp Lys Ser Ser Gln Ser Ser Gln Pro Ala Arg Ala Leu 
145                 150                 155                 160 


Gly Ser Pro Gly His Ser Ser Gly Arg Gly Asp Val Leu Leu Gln Tyr 
                165                 170                 175     


Pro His Cys Ser Gly Val Cys Pro Leu Ser Gln Gly Asp Ala Ala Gly 
            180                 185                 190         


Glu Leu Val Trp Val Gly Ser Phe Pro Leu Gln Xaa Gly Gln Met Pro 
        195                 200                 205             


Gly Leu Ser Pro Ser 
    210             


<210> 3648
<211> 79
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<400> 3648
Met Xaa Ala His Ser Phe Ala Leu Pro Val Ile Ile Phe Xaa Xaa Phe 
1               5                   10                  15      


Trp Gly Leu Val Gly Ile Ala Gly Pro Trp Phe Val Pro Lys Gly Pro 
            20                  25                  30          


Asn Arg Gly Val Ile Ile Xaa Met Leu Val Ala Xaa Ala Val Cys Cys 
        35                  40                  45              


Tyr Leu Phe Phe Gln Ala Ala Pro Tyr Xaa His Glu Ile Xaa Xaa Leu 
    50                  55                  60                  


Glu Ile Cys Xaa Trp Glu Phe Leu Leu Phe Met Asn Ala Pro Arg 
65                  70                  75                  


<210> 3649
<211> 187
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<400> 3649
Met Xaa Ala His Ser Phe Ala Leu Pro Val Ile Ile Phe Xaa Xaa Phe 
1               5                   10                  15      


Trp Gly Leu Val Gly Ile Ala Gly Pro Trp Phe Val Pro Lys Gly Pro 
            20                  25                  30          


Asn Arg Gly Val Ile Ile Xaa Met Leu Val Ala Xaa Ala Val Cys Cys 
        35                  40                  45              


Tyr Leu Phe Trp Leu Ile Ala Ile Leu Ala Gln Leu Asn Pro Leu Phe 
    50                  55                  60                  


Gly Pro Gln Leu Lys Asn Glu Xaa Ile Trp Cys Pro Ala Leu Gly Met 
65                  70                  75                  80  


Xaa Val Ala Pro Leu Ser Leu Xaa Xaa Pro Ser Ser Gly Pro Ser Pro 
                85                  90                  95      


Xaa Gln Leu Cys Leu Val Xaa Ser Ser Leu Leu Leu Ala Pro Arg Asp 
            100                 105                 110         


Pro Asp Pro Gln Gly Leu Pro Gly Ser Trp Lys Ser Ser Gln Ser Ser 
        115                 120                 125             


Gln Pro Ala Arg Ala Leu Gly Ser Pro Gly His Ser Ser Gly Arg Gly 
    130                 135                 140                 


Asp Val Leu Leu Gln Tyr Pro His Cys Ser Gly Val Cys Pro Leu Ser 
145                 150                 155                 160 


Gln Gly Asp Ala Ala Gly Glu Leu Val Trp Val Gly Ser Phe Pro Leu 
                165                 170                 175     


Gln Xaa Gly Gln Met Pro Gly Leu Ser Pro Ser 
            180                 185         


<210> 3650
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<400> 3650
Met Xaa Ala His Ser Phe Ala Leu Pro Val Ile Ile Phe Xaa Xaa Phe 
1               5                   10                  15      


Trp Gly Leu Val Gly Ile Ala Gly Pro Trp Phe Val Pro Lys Gly Pro 
            20                  25                  30          


Asn Arg Gly Val Ile Ile Xaa Met Leu Val Ala Xaa Ala Val Cys Cys 
        35                  40                  45              


Tyr Leu Phe Trp Leu Ile Ala Ile Leu Ala Gln Leu Asn Pro Leu Phe 
    50                  55                  60                  


Gly Pro Gln Leu Lys Asn Glu Xaa Ile Trp Tyr Val Arg Phe Leu Trp 
65                  70                  75                  80  


Glu 
    


<210> 3651
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<400> 3651
Met Xaa Ala His Ser Phe Ala Leu Pro Val Ile Ile Phe Xaa Xaa Phe 
1               5                   10                  15      


Trp Gly Leu Val Gly Ile Ala Gly Pro Trp Phe Val Pro Lys Gly Pro 
            20                  25                  30          


Asn Arg Gly Val Ile Ile Xaa Met Leu Val Ala Xaa Ala Val Cys Cys 
        35                  40                  45              


Tyr Leu Leu Cys Pro Ala Leu Gly Met Xaa Val Ala Pro Leu Ser Leu 
    50                  55                  60                  


Xaa Xaa Pro Ser Ser Gly Pro Ser Pro Xaa Gln Leu Cys Leu Val Xaa 
65                  70                  75                  80  


Ser Ser Leu Leu Leu Ala Pro Arg Asp Pro Asp Pro Gln Gly Leu Pro 
                85                  90                  95      


Gly Ser Trp Lys Ser Ser Gln Ser Ser Gln Pro Ala Arg Ala Leu Gly 
            100                 105                 110         


Ser Pro Gly His Ser Ser Gly Arg Gly Asp Val Leu Leu Gln Tyr Pro 
        115                 120                 125             


His Cys Ser Gly Val Cys Pro Leu Ser Gln Gly Asp Ala Ala Gly Glu 
    130                 135                 140                 


Leu Val Trp Val Gly Ser Phe Pro Leu Gln Xaa Gly Gln Met Pro Gly 
145                 150                 155                 160 


Leu Ser Pro Ser 
                


<210> 3652
<211> 185
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<400> 3652
Met Ala Gly Ala Ala Met Tyr Glu Leu Val Arg Val Gly His Ser Glu 
1               5                   10                  15      


Leu Val Gly Glu Ile Ile Arg Leu Glu Gly Asp Met Ala Xaa Ile Gln 
            20                  25                  30          


Val Tyr Glu Glu Xaa Ser Gly Val Ser Val Gly Asp Pro Val Leu Arg 
        35                  40                  45              


Xaa Gly Lys Pro Leu Ser Val Glu Leu Gly Pro Gly Ile Met Gly Ala 
    50                  55                  60                  


Ile Phe Asp Gly Ile Gln Arg Pro Leu Ser Asp Ile Ser Ser Gln Xaa 
65                  70                  75                  80  


Gln Ser Ile Tyr Ile Pro Arg Gly Val Asn Val Ser Ala Leu Ser Arg 
                85                  90                  95      


Asp Ile Lys Trp Asp Phe Xaa Pro Cys Lys Asn Leu Arg Val Gly Ser 
            100                 105                 110         


His Ile Xaa Gly Gly Asp Ile Tyr Gly Ile Val Ser Glu Asn Ser Leu 
        115                 120                 125             


Ile Lys His Lys Ile Met Leu Pro Pro Arg Asn Arg Gly Xaa Val Xaa 
    130                 135                 140                 


Tyr Ile Ala Pro Pro Gly Asn Tyr Asp Xaa Ser Asp Val Val Leu Glu 
145                 150                 155                 160 


Leu Glu Phe Glu Gly Val Lys Glu Lys Phe Xaa Met Val Gln Val Trp 
                165                 170                 175     


Pro Val Arg Gln Val Arg Pro Val Xaa 
            180                 185 


<210> 3653
<211> 49
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<400> 3653
Met Asp Phe Ser Lys Leu Pro Lys Ile Leu Asp Glu Asp Lys Glu Ser 
1               5                   10                  15      


Xaa Phe Gly Tyr Val His Gly Val Ser Gly Pro Ala Phe Xaa Pro Cys 
            20                  25                  30          


Ile Ile Ala Xaa Leu Arg Xaa Tyr Leu Asn Pro Xaa Ser Gly Tyr Ser 
        35                  40                  45              


Leu 
    


<210> 3654
<211> 221
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<400> 3654
Met Asp Phe Ser Lys Leu Pro Lys Ile Leu Asp Glu Asp Lys Glu Ser 
1               5                   10                  15      


Xaa Phe Gly Tyr Val His Gly Val Ser Gly Pro Val Val Xaa Ala Cys 
            20                  25                  30          


Asp Met Ala Gly Ala Ala Met Tyr Glu Leu Val Arg Val Gly His Ser 
        35                  40                  45              


Glu Leu Val Gly Glu Ile Ile Arg Leu Glu Gly Asp Met Ala Xaa Ile 
    50                  55                  60                  


Gln Val Tyr Glu Glu Xaa Ser Gly Val Ser Val Gly Asp Pro Val Leu 
65                  70                  75                  80  


Arg Xaa Gly Lys Pro Leu Ser Val Glu Leu Gly Pro Gly Ile Met Gly 
                85                  90                  95      


Ala Ile Phe Asp Gly Ile Gln Arg Pro Leu Ser Asp Ile Ser Ser Gln 
            100                 105                 110         


Xaa Gln Ser Ile Tyr Ile Pro Arg Gly Val Asn Val Ser Ala Leu Ser 
        115                 120                 125             


Arg Asp Ile Lys Trp Asp Phe Xaa Pro Cys Lys Asn Leu Arg Val Gly 
    130                 135                 140                 


Ser His Ile Xaa Gly Gly Asp Ile Tyr Gly Ile Val Ser Glu Asn Ser 
145                 150                 155                 160 


Leu Ile Lys His Lys Ile Met Leu Pro Pro Arg Asn Arg Gly Xaa Val 
                165                 170                 175     


Xaa Tyr Ile Ala Pro Pro Gly Asn Tyr Asp Xaa Ser Asp Val Val Leu 
            180                 185                 190         


Glu Leu Glu Phe Glu Gly Val Lys Glu Lys Phe Xaa Met Val Gln Val 
        195                 200                 205             


Trp Pro Val Arg Gln Val Arg Pro Val Xaa Glu Lys Leu 
    210                 215                 220     


<210> 3655
<211> 617
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<400> 3655
Met Asp Phe Ser Lys Leu Pro Lys Ile Leu Asp Glu Asp Lys Glu Ser 
1               5                   10                  15      


Xaa Phe Gly Tyr Val His Gly Val Ser Gly Pro Val Val Xaa Ala Cys 
            20                  25                  30          


Asp Met Ala Gly Ala Ala Met Tyr Glu Leu Val Arg Val Gly His Ser 
        35                  40                  45              


Glu Leu Val Gly Glu Ile Ile Arg Leu Glu Gly Asp Met Ala Xaa Ile 
    50                  55                  60                  


Gln Val Tyr Glu Glu Xaa Ser Gly Val Ser Val Gly Asp Pro Val Leu 
65                  70                  75                  80  


Arg Xaa Gly Lys Pro Leu Ser Val Glu Leu Gly Pro Gly Ile Met Gly 
                85                  90                  95      


Ala Ile Phe Asp Gly Ile Gln Arg Pro Leu Ser Asp Ile Ser Ser Gln 
            100                 105                 110         


Xaa Gln Ser Ile Tyr Ile Pro Arg Gly Val Asn Val Ser Ala Leu Ser 
        115                 120                 125             


Arg Asp Ile Lys Trp Asp Phe Xaa Pro Cys Lys Asn Leu Arg Val Gly 
    130                 135                 140                 


Ser His Ile Xaa Gly Gly Asp Ile Tyr Gly Ile Val Ser Glu Asn Ser 
145                 150                 155                 160 


Leu Ile Lys His Lys Ile Met Leu Pro Pro Arg Asn Arg Gly Xaa Val 
                165                 170                 175     


Xaa Tyr Ile Ala Pro Pro Gly Asn Tyr Asp Xaa Ser Asp Val Val Leu 
            180                 185                 190         


Glu Leu Glu Phe Glu Gly Val Lys Glu Lys Phe Xaa Met Val Gln Val 
        195                 200                 205             


Trp Pro Val Arg Gln Val Arg Pro Val Xaa Glu Lys Leu Pro Ala Asn 
    210                 215                 220                 


His Pro Leu Leu Xaa Gly Gln Arg Val Leu Asp Ala Leu Phe Pro Cys 
225                 230                 235                 240 


Val Gln Gly Gly Xaa Xaa Ala Ile Pro Gly Ala Phe Gly Cys Gly Lys 
                245                 250                 255     


Xaa Val Ile Ser Gln Ser Leu Ser Lys Tyr Ser Asn Ser Asp Val Ile 
            260                 265                 270         


Ile Tyr Val Gly Cys Gly Glu Arg Gly Asn Glu Met Ser Glu Val Leu 
        275                 280                 285             


Arg Asp Phe Pro Glu Leu Xaa Met Glu Val Asp Gly Lys Val Glu Ser 
    290                 295                 300                 


Ile Met Lys Arg Xaa Ala Leu Val Ala Asn Xaa Ser Asn Met Pro Val 
305                 310                 315                 320 


Ala Ala Arg Glu Ala Ser Ile Tyr Xaa Gly Ile Xaa Leu Ser Glu Tyr 
                325                 330                 335     


Phe Arg Asp Met Gly Tyr His Val Ser Met Met Ala Asp Ser Xaa Ser 
            340                 345                 350         


Arg Trp Ala Glu Ala Leu Arg Glu Ile Ser Gly Arg Leu Ala Glu Met 
        355                 360                 365             


Pro Ala Asp Ser Gly Tyr Pro Ala Tyr Leu Gly Ala Arg Leu Ala Ser 
    370                 375                 380                 


Phe Tyr Glu Arg Ala Gly Arg Val Lys Cys Leu Gly Asn Pro Glu Arg 
385                 390                 395                 400 


Glu Gly Ser Val Ser Ile Val Gly Ala Val Ser Pro Pro Gly Gly Asp 
                405                 410                 415     


Phe Ser Asp Pro Val Xaa Ser Ala Xaa Leu Gly Ile Val Gln Val Phe 
            420                 425                 430         


Trp Gly Leu Asp Lys Lys Leu Ala Gln Arg Lys His Phe Pro Ser Val 
        435                 440                 445             


Asn Trp Leu Ile Ser Tyr Ser Lys Tyr Met Arg Ala Leu Asp Glu Tyr 
    450                 455                 460                 


Tyr Asp Lys His Phe Xaa Glu Phe Val Pro Leu Arg Xaa Lys Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Gln Glu Glu Glu Asp Leu Ala Glu Ile Val Gln Leu Val 
                485                 490                 495     


Gly Lys Ala Ser Leu Ala Glu Xaa Asp Lys Ile Xaa Leu Glu Val Ala 
            500                 505                 510         


Lys Leu Ile Lys Asp Asp Phe Leu Gln Gln Asn Gly Tyr Xaa Pro Tyr 
        515                 520                 525             


Asp Arg Phe Cys Pro Phe Tyr Lys Xaa Val Gly Met Leu Ser Asn Met 
    530                 535                 540                 


Ile Ala Phe Tyr Asp Met Ala Arg Arg Ala Val Glu Xaa Xaa Ala Gln 
545                 550                 555                 560 


Ser Asp Asn Lys Ile Xaa Trp Ser Ile Ile Arg Glu His Met Gly Asp 
                565                 570                 575     


Ile Leu Tyr Lys Leu Ser Ser Met Lys Phe Lys Asp Pro Leu Lys Asp 
            580                 585                 590         


Gly Glu Ala Lys Ile Lys Ser Asp Tyr Ala Gln Leu Leu Glu Asp Met 
        595                 600                 605             


Gln Asn Ala Phe Arg Ser Leu Glu Asp 
    610                 615         


<210> 3656
<211> 496
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<400> 3656
Met Ala Met Glu Ile Asp Ser Arg Pro Gly Gly Leu Pro Gly Ser Ser 
1               5                   10                  15      


Cys Asn Leu Gly Ala Ala Arg Glu His Met Gln Ala Val Xaa Arg Asn 
            20                  25                  30          


Tyr Ile Xaa His Pro Arg Val Xaa Tyr Arg Xaa Val Cys Ser Val Asn 
        35                  40                  45              


Gly Pro Leu Val Val Leu Asp Arg Val Lys Phe Ala Gln Tyr Ala Glu 
    50                  55                  60                  


Ile Val His Phe Xaa Leu Pro Asp Gly Xaa Gln Arg Ser Gly Gln Val 
65                  70                  75                  80  


Leu Glu Val Ala Gly Xaa Lys Ala Ile Val Gln Val Phe Glu Gly Xaa 
                85                  90                  95      


Ser Gly Ile Asp Ala Arg Lys Xaa Xaa Cys Glu Phe Xaa Gly Asp Ile 
            100                 105                 110         


Leu Arg Xaa Pro Val Ser Glu Asp Met Leu Gly Arg Val Phe Asn Gly 
        115                 120                 125             


Ser Gly Lys Pro Ile Asp Lys Gly Pro Val Val Met Ala Glu Asp Phe 
    130                 135                 140                 


Leu Asp Ile Asn Gly Gln Pro Ile Asn Pro His Ser Arg Ile Tyr Pro 
145                 150                 155                 160 


Glu Glu Met Ile Gln Xaa Gly Ile Ser Pro Ile Asp Val Met Asn Ser 
                165                 170                 175     


Ile Ala Arg Gly Gln Lys Ile Pro Ile Phe Ser Ala Ala Gly Leu Pro 
            180                 185                 190         


His Asn Glu Ile Ala Ala Gln Ile Cys Arg Gln Ala Gly Leu Val Lys 
        195                 200                 205             


Lys Ser Lys Ala Val Leu Asp Tyr His Asp Asp Asn Phe Ala Ile Val 
    210                 215                 220                 


Phe Ala Ala Met Gly Val Asn Met Glu Xaa Ala Arg Phe Phe Lys Ser 
225                 230                 235                 240 


Asp Phe Glu Gln Asn Gly Xaa Met Gly Asn Val Cys Leu Phe Leu Asn 
                245                 250                 255     


Leu Ala Asn Asp Pro Xaa Ile Glu Arg Ile Ile Xaa Pro Arg Leu Ala 
            260                 265                 270         


Leu Xaa Xaa Ala Glu Phe Leu Ala Tyr Gln Cys Glu Lys His Val Leu 
        275                 280                 285             


Val Ile Leu Xaa Asp Met Ser Ser Tyr Ala Glu Ala Leu Arg Glu Val 
    290                 295                 300                 


Ser Ala Ala Arg Glu Glu Val Pro Gly Arg Arg Gly Phe Pro Gly Tyr 
305                 310                 315                 320 


Met Tyr Xaa Asp Leu Ala Xaa Ile Tyr Glu Arg Ala Gly Arg Val Glu 
                325                 330                 335     


Asp Ile Xaa His Pro Ile Pro Asp Leu Xaa Gly Phe Ile Xaa Glu Gly 
            340                 345                 350         


Gln Ile Tyr Val Asp Arg Gln Leu His Asn Arg Gln Ile Tyr Pro Pro 
        355                 360                 365             


Ile Asn Val Leu Pro Ser Leu Ser Arg Leu Met Lys Ser Ala Ile Gly 
    370                 375                 380                 


Glu Gly Met Xaa Arg Lys Asp His Gly Asp Val Ser Asn Gln Leu Tyr 
385                 390                 395                 400 


Ala Cys Tyr Ala Ile Gly Lys Asp Val Gln Ala Met Lys Ala Val Val 
                405                 410                 415     


Gly Glu Glu Ala Leu Xaa Ser Glu Asp Leu Leu Tyr Leu Glu Phe Leu 
            420                 425                 430         


Gln Lys Phe Glu Lys Asn Phe Ile Asn Gln Gly Pro Tyr Glu Asn Arg 
        435                 440                 445             


Ser Val Phe Glu Ser Leu Asp Leu Gly Trp Lys Leu Leu Arg Ile Phe 
    450                 455                 460                 


Pro Lys Glu Met Leu Lys Arg Ile Pro Gln Ala Val Ile Asp Glu Phe 
465                 470                 475                 480 


Tyr Ser Arg Glu Gly Ala Leu Gln Asp Leu Ala Pro Asp Xaa Ala Leu 
                485                 490                 495     


<210> 3657
<211> 513
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<400> 3657
Met Ala Met Glu Ile Asp Ser Arg Pro Gly Gly Leu Pro Gly Ser Ser 
1               5                   10                  15      


Cys Asn Leu Gly Ala Ala Arg Glu His Met Gln Ala Val Xaa Arg Asn 
            20                  25                  30          


Tyr Ile Xaa His Pro Arg Val Xaa Tyr Arg Xaa Val Cys Ser Val Asn 
        35                  40                  45              


Gly Pro Leu Val Val Leu Asp Arg Val Lys Phe Ala Gln Tyr Ala Glu 
    50                  55                  60                  


Ile Val His Phe Xaa Leu Pro Asp Gly Xaa Gln Arg Ser Gly Gln Val 
65                  70                  75                  80  


Leu Glu Val Ala Gly Xaa Lys Ala Ile Val Gln Val Phe Glu Gly Xaa 
                85                  90                  95      


Ser Gly Ile Asp Ala Arg Lys Xaa Xaa Cys Glu Phe Xaa Gly Asp Ile 
            100                 105                 110         


Leu Arg Xaa Pro Val Ser Glu Asp Met Leu Gly Arg Val Phe Asn Gly 
        115                 120                 125             


Ser Gly Lys Pro Ile Asp Lys Gly Pro Val Val Met Ala Glu Asp Phe 
    130                 135                 140                 


Leu Asp Ile Asn Gly Gln Pro Ile Asn Pro His Ser Arg Ile Tyr Pro 
145                 150                 155                 160 


Glu Glu Met Ile Gln Xaa Gly Ile Ser Pro Ile Asp Val Met Asn Ser 
                165                 170                 175     


Ile Ala Arg Gly Gln Lys Ile Pro Ile Phe Ser Ala Ala Gly Leu Pro 
            180                 185                 190         


His Asn Glu Ile Ala Ala Gln Ile Cys Arg Gln Ala Gly Leu Val Lys 
        195                 200                 205             


Lys Ser Lys Ala Val Leu Asp Tyr His Asp Asp Asn Phe Ala Ile Val 
    210                 215                 220                 


Phe Ala Ala Met Gly Val Asn Met Glu Xaa Ala Arg Phe Phe Lys Ser 
225                 230                 235                 240 


Asp Phe Glu Gln Asn Gly Xaa Met Gly Asn Val Cys Leu Phe Leu Asn 
                245                 250                 255     


Leu Ala Asn Asp Pro Xaa Ile Glu Arg Ile Ile Xaa Pro Arg Leu Ala 
            260                 265                 270         


Leu Xaa Xaa Ala Glu Phe Leu Ala Tyr Gln Cys Glu Lys His Val Leu 
        275                 280                 285             


Val Ile Leu Xaa Asp Met Ser Ser Tyr Ala Glu Ala Leu Arg Glu Val 
    290                 295                 300                 


Ser Ala Ala Arg Glu Glu Val Pro Gly Arg Arg Gly Phe Pro Gly Tyr 
305                 310                 315                 320 


Met Tyr Xaa Asp Leu Ala Xaa Ile Tyr Glu Arg Ala Gly Arg Val Glu 
                325                 330                 335     


Gly Arg Gly Gly Ser Ile Xaa Gln Ile Pro Ile Leu Xaa Met Pro Asn 
            340                 345                 350         


Asp Asp Ile Xaa His Pro Ile Pro Asp Leu Xaa Gly Phe Ile Xaa Glu 
        355                 360                 365             


Gly Gln Ile Tyr Val Asp Arg Gln Leu His Asn Arg Gln Ile Tyr Pro 
    370                 375                 380                 


Pro Ile Asn Val Leu Pro Ser Leu Ser Arg Leu Met Lys Ser Ala Ile 
385                 390                 395                 400 


Gly Glu Gly Met Xaa Arg Lys Asp His Gly Asp Val Ser Asn Gln Leu 
                405                 410                 415     


Tyr Ala Cys Tyr Ala Ile Gly Lys Asp Val Gln Ala Met Lys Ala Val 
            420                 425                 430         


Val Gly Glu Glu Ala Leu Xaa Ser Glu Asp Leu Leu Tyr Leu Glu Phe 
        435                 440                 445             


Leu Gln Lys Phe Glu Lys Asn Phe Ile Asn Gln Gly Pro Tyr Glu Asn 
    450                 455                 460                 


Arg Ser Val Phe Glu Ser Leu Asp Leu Gly Trp Lys Leu Leu Arg Ile 
465                 470                 475                 480 


Phe Pro Lys Glu Met Leu Lys Arg Ile Pro Gln Ala Val Ile Asp Glu 
                485                 490                 495     


Phe Tyr Ser Arg Glu Gly Ala Leu Gln Asp Leu Ala Pro Asp Xaa Ala 
            500                 505                 510         


Leu 
    


<210> 3658
<211> 248
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 3658
Met Ala Met Glu Ile Asp Ser Arg Pro Gly Gly Leu Pro Gly Ser Ser 
1               5                   10                  15      


Cys Asn Leu Gly Ala Ala Arg Glu His Met Gln Ala Val Xaa Arg Asn 
            20                  25                  30          


Tyr Ile Xaa His Pro Arg Val Xaa Tyr Arg Xaa Val Cys Ser Val Asn 
        35                  40                  45              


Gly Pro Leu Val Val Leu Asp Arg Val Lys Phe Ala Gln Tyr Ala Glu 
    50                  55                  60                  


Ile Val His Phe Xaa Leu Pro Asp Gly Xaa Gln Arg Ser Gly Gln Val 
65                  70                  75                  80  


Leu Glu Val Ala Gly Xaa Lys Ala Ile Val Gln Val Phe Glu Gly Xaa 
                85                  90                  95      


Ser Gly Ile Asp Ala Arg Lys Xaa Xaa Cys Glu Phe Xaa Gly Asp Ile 
            100                 105                 110         


Leu Arg Xaa Pro Val Ser Glu Asp Met Leu Gly Arg Val Phe Asn Gly 
        115                 120                 125             


Ser Gly Lys Pro Ile Asp Lys Gly Pro Val Val Met Ala Glu Asp Phe 
    130                 135                 140                 


Leu Asp Ile Asn Gly Gln Pro Ile Asn Pro His Ser Arg Ile Tyr Pro 
145                 150                 155                 160 


Glu Glu Met Ile Gln Xaa Gly Ile Ser Pro Ile Asp Val Met Asn Ser 
                165                 170                 175     


Ile Ala Arg Gly Gln Lys Ile Pro Ile Phe Ser Ala Ala Gly Leu Pro 
            180                 185                 190         


His Asn Glu Ile Ala Ala Gln Ile Cys Arg Gln Ala Gly Leu Val Lys 
        195                 200                 205             


Lys Ser Lys Ala Val Leu Asp Tyr His Asp Asp Asn Phe Ala Ile Val 
    210                 215                 220                 


Phe Ala Ala Met Gly Val Arg Arg Leu Ser Arg Leu Ala Ser Glu His 
225                 230                 235                 240 


Gly Asp Ser Gln Ile Leu Gln Val 
                245             


<210> 3659
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 3659
Met Lys Ser Ala Ile Gly Glu Gly Met Xaa Arg Lys Asp His Gly Asp 
1               5                   10                  15      


Val Ser Asn Gln Leu Tyr Ala Cys Tyr Ala Ile Gly Lys Asp Val Gln 
            20                  25                  30          


Ala Met Lys Ala Val Val Gly Glu Glu Ala Leu Xaa Ser Glu Asp Leu 
        35                  40                  45              


Leu Tyr Leu Glu Phe Leu Gln Lys Phe Glu Lys Asn Phe Ile Asn Gln 
    50                  55                  60                  


Gly Pro Tyr Glu Asn Arg Ser Val Phe Glu Ser Leu Asp Leu Gly Trp 
65                  70                  75                  80  


Lys Leu Leu Arg Ile Phe Pro Lys Glu Met Leu Lys Arg Ile Pro Gln 
                85                  90                  95      


Ala Val Ile Asp Glu Phe Tyr Ser Arg Glu Gly Ala Leu Gln Asp Leu 
            100                 105                 110         


Ala Pro Asp Xaa Ala Leu 
        115             


<210> 3660
<211> 74
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<400> 3660
Met Leu Gly Arg Val Phe Asn Gly Ser Gly Lys Pro Ile Asp Lys Gly 
1               5                   10                  15      


Pro Val Val Met Ala Glu Asp Phe Leu Asp Ile Asn Gly Gln Pro Ile 
            20                  25                  30          


Asn Pro His Ser Arg Ile Tyr Pro Glu Glu Met Ile Gln Xaa Gly Ile 
        35                  40                  45              


Ser Pro Ile Asp Val Met Asn Ser Ile Ala Arg Gly Gln Lys Ile Pro 
    50                  55                  60                  


Ile Phe Ser Ala Ala Gly Leu Pro His Asn 
65                  70                  


<210> 3661
<211> 249
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<400> 3661
Met Xaa Leu Xaa Ala Met Val Ala Gly Pro Val Xaa Ala Asn Asp Pro 
1               5                   10                  15      


Asp Gly Pro Gly Trp Glu Gly Gly Gly Val Trp Arg Glu Glu Gly Lys 
            20                  25                  30          


Ala Glu Asp Ala Ser Val Cys Val Ser Arg Val Phe Gly Val Arg Pro 
        35                  40                  45              


Leu Leu Xaa Pro Ala Pro Pro Pro Ala Tyr Arg Xaa Val Cys Ser Val 
    50                  55                  60                  


Asn Gly Pro Leu Val Val Leu Asp Arg Val Lys Phe Ala Gln Tyr Ala 
65                  70                  75                  80  


Glu Ile Val His Phe Xaa Leu Pro Asp Gly Xaa Gln Arg Ser Gly Gln 
                85                  90                  95      


Val Leu Glu Val Ala Gly Xaa Lys Ala Ile Val Gln Val Phe Glu Gly 
            100                 105                 110         


Xaa Ser Gly Ile Asp Ala Arg Lys Xaa Xaa Cys Glu Phe Xaa Gly Asp 
        115                 120                 125             


Ile Leu Arg Xaa Pro Val Ser Glu Asp Met Leu Gly Arg Val Phe Asn 
    130                 135                 140                 


Gly Ser Gly Lys Pro Ile Asp Lys Gly Pro Val Val Met Ala Glu Asp 
145                 150                 155                 160 


Phe Leu Asp Ile Asn Gly Gln Pro Ile Asn Pro His Ser Arg Ile Tyr 
                165                 170                 175     


Pro Glu Glu Met Ile Gln Xaa Gly Ile Ser Pro Ile Asp Val Met Asn 
            180                 185                 190         


Ser Ile Ala Arg Gly Gln Lys Ile Pro Ile Phe Ser Ala Ala Gly Leu 
        195                 200                 205             


Pro His Asn Glu Ile Ala Ala Gln Ile Cys Arg Gln Ala Gly Leu Val 
    210                 215                 220                 


Lys Lys Ser Lys Ala Val Leu Asp Tyr His Asp Asp Asn Phe Ala Ile 
225                 230                 235                 240 


Val Phe Ala Ala Met Gly Val Arg Arg 
                245                 


<210> 3662
<211> 511
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<400> 3662
Met Ala Leu Arg Ala Met Arg Gly Ile Val Asn Gly Ala Ala Pro Glu 
1               5                   10                  15      


Leu Pro Val Pro Xaa Gly Gly Pro Ala Val Gly Ala Arg Glu Gln Ala 
            20                  25                  30          


Leu Ala Val Ser Arg Asn Tyr Leu Ser Gln Pro Arg Leu Xaa Tyr Lys 
        35                  40                  45              


Xaa Val Ser Gly Val Asn Gly Pro Leu Val Ile Leu Asp His Val Lys 
    50                  55                  60                  


Phe Pro Arg Tyr Ala Glu Ile Val His Leu Xaa Leu Pro Asp Gly Xaa 
65                  70                  75                  80  


Lys Arg Ser Gly Gln Val Leu Glu Val Ser Gly Ser Lys Ala Val Val 
                85                  90                  95      


Gln Val Phe Glu Gly Xaa Ser Gly Ile Asp Ala Lys Lys Xaa Ser Cys 
            100                 105                 110         


Glu Phe Xaa Gly Asp Ile Leu Arg Xaa Pro Val Ser Glu Asp Met Leu 
        115                 120                 125             


Gly Arg Val Phe Asn Gly Ser Gly Lys Pro Ile Asp Arg Gly Pro Val 
    130                 135                 140                 


Val Leu Ala Glu Asp Phe Leu Asp Ile Met Gly Gln Pro Ile Asn Pro 
145                 150                 155                 160 


Gln Cys Arg Ile Tyr Pro Glu Glu Met Ile Gln Xaa Gly Ile Ser Ala 
                165                 170                 175     


Ile Asp Gly Met Asn Ser Ile Ala Arg Gly Gln Lys Ile Pro Ile Phe 
            180                 185                 190         


Ser Ala Ala Gly Leu Pro His Asn Glu Ile Ala Ala Gln Ile Cys Arg 
        195                 200                 205             


Gln Ala Gly Leu Val Lys Lys Ser Lys Asp Val Val Asp Tyr Ser Glu 
    210                 215                 220                 


Glu Asn Phe Ala Ile Val Phe Ala Ala Met Gly Val Asn Met Glu Xaa 
225                 230                 235                 240 


Ala Arg Phe Phe Lys Ser Asp Phe Glu Glu Asn Gly Ser Met Asp Asn 
                245                 250                 255     


Val Cys Leu Phe Leu Asn Leu Ala Asn Asp Pro Xaa Ile Glu Arg Ile 
            260                 265                 270         


Ile Xaa Pro Arg Leu Ala Leu Xaa Xaa Ala Glu Phe Leu Ala Tyr Gln 
        275                 280                 285             


Cys Glu Lys His Val Leu Val Ile Leu Xaa Asp Met Ser Ser Tyr Ala 
    290                 295                 300                 


Glu Ala Leu Arg Glu Val Ser Ala Ala Arg Glu Glu Val Pro Gly Arg 
305                 310                 315                 320 


Arg Gly Phe Pro Gly Tyr Met Tyr Xaa Asp Leu Ala Xaa Ile Tyr Glu 
                325                 330                 335     


Arg Ala Gly Arg Val Glu Gly Arg Asn Gly Ser Ile Xaa Gln Ile Pro 
            340                 345                 350         


Ile Leu Xaa Met Pro Asn Asp Asp Ile Xaa His Pro Ile Pro Asp Leu 
        355                 360                 365             


Xaa Gly Tyr Ile Xaa Glu Gly Gln Ile Tyr Val Asp Arg Gln Leu His 
    370                 375                 380                 


Asn Arg Gln Ile Tyr Pro Pro Ile Asn Val Leu Pro Ser Leu Ser Arg 
385                 390                 395                 400 


Leu Met Lys Ser Ala Ile Gly Glu Gly Met Xaa Arg Lys Asp His Ala 
                405                 410                 415     


Asp Val Ser Asn Gln Leu Tyr Ala Cys Tyr Ala Ile Gly Lys Asp Val 
            420                 425                 430         


Gln Ala Met Lys Ala Val Val Gly Glu Glu Ala Leu Xaa Ser Asp Asp 
        435                 440                 445             


Leu Leu Tyr Leu Glu Phe Leu Gln Lys Phe Glu Arg Asn Phe Ile Ala 
    450                 455                 460                 


Gln Gly Pro Tyr Glu Asn Arg Xaa Val Phe Glu Xaa Leu Asp Ile Gly 
465                 470                 475                 480 


Trp Gln Leu Leu Arg Ile Phe Pro Lys Glu Met Leu Lys Arg Ile Pro 
                485                 490                 495     


Gln Ser Xaa Leu Ser Glu Phe Tyr Pro Arg Asp Ser Ala Lys His 
            500                 505                 510     


<210> 3663
<211> 66
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<400> 3663
Met Ala Leu Arg Ala Met Arg Gly Ile Val Asn Gly Ala Ala Pro Glu 
1               5                   10                  15      


Leu Pro Val Pro Xaa Gly Gly Pro Ala Val Gly Ala Arg Glu Gln Ala 
            20                  25                  30          


Leu Ala Val Ser Arg Asn Tyr Leu Ser Gln Pro Arg Leu Xaa Tyr Lys 
        35                  40                  45              


Xaa Val Ser Gly Val Asn Gly Pro Leu Val Ile Leu Asp His Val Lys 
    50                  55                  60                  


Val Cys 
65      


<210> 3664
<211> 199
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<400> 3664
Xaa Gly Ala Ala Pro Glu Leu Pro Val Pro Xaa Gly Gly Pro Ala Val 
1               5                   10                  15      


Gly Ala Arg Glu Gln Ala Leu Ala Val Ser Arg Asn Tyr Leu Ser Gln 
            20                  25                  30          


Pro Arg Leu Xaa Tyr Lys Xaa Val Ser Gly Val Asn Gly Pro Leu Val 
        35                  40                  45              


Ile Leu Asp His Val Lys Phe Pro Arg Tyr Ala Glu Ile Val His Leu 
    50                  55                  60                  


Xaa Leu Pro Asp Gly Xaa Lys Arg Ser Gly Gln Val Leu Glu Val Ser 
65                  70                  75                  80  


Gly Ser Lys Ala Val Val Gln Val Phe Glu Gly Xaa Ser Gly Ile Asp 
                85                  90                  95      


Ala Lys Lys Xaa Ser Cys Glu Phe Xaa Gly Asp Ile Leu Arg Xaa Pro 
            100                 105                 110         


Val Ser Glu Asp Met Leu Gly Arg Val Phe Asn Gly Ser Gly Lys Pro 
        115                 120                 125             


Ile Asp Arg Gly Pro Val Val Leu Ala Glu Asp Phe Leu Asp Ile Met 
    130                 135                 140                 


Gly Gln Pro Ile Asn Pro Gln Cys Arg Ile Tyr Pro Glu Glu Met Ile 
145                 150                 155                 160 


Gln Xaa Gly Ile Ser Ala Ile Asp Gly Met Asn Ser Ile Ala Arg Gly 
                165                 170                 175     


Gln Lys Ile Pro Ile Phe Ser Ala Ala Gly Leu Pro His Asn Glu Val 
            180                 185                 190         


Arg Xaa Gly Ile Gly Leu Leu 
        195                 


<210> 3665
<211> 49
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<400> 3665
Xaa Gln Ala Met Lys Ala Val Val Gly Glu Glu Ala Leu Xaa Ser Asp 
1               5                   10                  15      


Asp Leu Leu Tyr Leu Glu Phe Leu Gln Lys Phe Glu Arg Asn Phe Ile 
            20                  25                  30          


Ala Gln Gly Val Ser Leu Cys Arg Pro Gly Trp Ser Xaa Val Val Arg 
        35                  40                  45              


Ser 
    


<210> 3666
<211> 56
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<400> 3666
Xaa Arg Gly Ile Val Asn Gly Ala Ala Pro Glu Leu Pro Val Pro Xaa 
1               5                   10                  15      


Gly Gly Pro Ala Val Gly Ala Arg Glu Gln Ala Leu Ala Val Ser Arg 
            20                  25                  30          


Asn Tyr Leu Ser Gln Pro Arg Leu Ser Tyr Xaa Ile Ser Pro Ile Ser 
        35                  40                  45              


Phe Val Xaa Phe Val Xaa Ser Ala 
    50                  55      


<210> 3667
<211> 307
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<400> 3667
Met Ala Asp Val Leu Glu Asp Ser Lys Asp Lys Val Gln Glu Asn Leu 
1               5                   10                  15      


Leu Ala Asn Gly Val Asp Leu Val Xaa Tyr Ile Xaa Arg Phe Gln Trp 
            20                  25                  30          


Asp Met Ala Lys Tyr Pro Ile Lys Gln Ser Leu Lys Asn Ile Ser Glu 
        35                  40                  45              


Ile Ile Ala Lys Gly Val Xaa Gln Ile Asp Asn Asp Leu Lys Ser Arg 
    50                  55                  60                  


Ala Ser Ala Tyr Asn Asn Leu Lys Gly Asn Leu Gln Asn Leu Glu Arg 
65                  70                  75                  80  


Lys Asn Ala Gly Ser Leu Leu Xaa Arg Ser Leu Ala Glu Ile Val Lys 
                85                  90                  95      


Lys Asp Asp Phe Val Leu Asp Ser Glu Tyr Leu Val Xaa Leu Leu Val 
            100                 105                 110         


Val Val Pro Lys Leu Asn His Asn Asp Trp Ile Lys Gln Tyr Glu Xaa 
        115                 120                 125             


Leu Ala Glu Met Val Val Pro Arg Ser Ser Asn Val Leu Ser Glu Asp 
    130                 135                 140                 


Gln Asp Ser Tyr Leu Cys Asn Val Xaa Leu Phe Arg Lys Ala Val Asp 
145                 150                 155                 160 


Asp Phe Arg His Lys Ala Arg Glu Asn Lys Phe Ile Val Arg Asp Phe 
                165                 170                 175     


Gln Tyr Asn Glu Glu Glu Met Lys Ala Asp Lys Glu Glu Met Asn Arg 
            180                 185                 190         


Leu Ser Xaa Asp Lys Lys Lys Gln Phe Gly Pro Leu Val Arg Trp Leu 
        195                 200                 205             


Lys Val Asn Phe Ser Glu Ala Phe Ile Ala Trp Ile His Val Lys Ala 
    210                 215                 220                 


Leu Arg Val Phe Val Glu Ser Val Leu Arg Tyr Gly Leu Pro Val Asn 
225                 230                 235                 240 


Phe Gln Ala Met Leu Leu Gln Pro Asn Lys Lys Xaa Leu Lys Lys Leu 
                245                 250                 255     


Arg Glu Val Leu His Glu Leu Tyr Lys His Leu Asp Ser Ser Ala Ala 
            260                 265                 270         


Ala Ile Ile Asp Ala Pro Met Asp Ile Pro Gly Leu Asn Leu Ser Gln 
        275                 280                 285             


Gln Glu Tyr Tyr Pro Tyr Val Tyr Tyr Lys Ile Asp Cys Asn Leu Leu 
    290                 295                 300                 


Glu Phe Lys 
305         


<210> 3668
<211> 382
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<400> 3668
Met Xaa Glu Phe Trp Leu Ile Ser Ala Pro Gly Glu Lys Xaa Cys Gln 
1               5                   10                  15      


Gln Xaa Trp Glu Lys Leu His Ala Ala Xaa Ser Lys Asn Asn Asn Leu 
            20                  25                  30          


Ala Val Xaa Ser Lys Phe Asn Ile Pro Asp Leu Lys Val Gly Xaa Leu 
        35                  40                  45              


Asp Val Leu Val Gly Leu Ser Asp Glu Leu Ala Lys Leu Asp Ala Phe 
    50                  55                  60                  


Val Glu Gly Val Val Lys Lys Val Ala Gln Tyr Met Ala Asp Val Leu 
65                  70                  75                  80  


Glu Asp Ser Lys Asp Lys Val Gln Glu Asn Leu Leu Ala Asn Gly Val 
                85                  90                  95      


Asp Leu Val Xaa Tyr Ile Xaa Arg Phe Gln Trp Asp Met Ala Lys Tyr 
            100                 105                 110         


Pro Ile Lys Gln Ser Leu Lys Asn Ile Ser Glu Ile Ile Ala Lys Gly 
        115                 120                 125             


Val Xaa Gln Ile Asp Asn Asp Leu Lys Ser Arg Ala Ser Ala Tyr Asn 
    130                 135                 140                 


Asn Leu Lys Gly Asn Leu Gln Asn Leu Glu Arg Lys Asn Ala Gly Ser 
145                 150                 155                 160 


Leu Leu Xaa Arg Ser Leu Ala Glu Ile Val Lys Lys Asp Asp Phe Val 
                165                 170                 175     


Leu Asp Ser Glu Tyr Leu Val Xaa Leu Leu Val Val Val Pro Lys Leu 
            180                 185                 190         


Asn His Asn Asp Trp Ile Lys Gln Tyr Glu Xaa Leu Ala Glu Met Val 
        195                 200                 205             


Val Pro Arg Ser Ser Asn Val Leu Ser Glu Asp Gln Asp Ser Tyr Leu 
    210                 215                 220                 


Cys Asn Val Xaa Leu Phe Arg Lys Ala Val Asp Asp Phe Arg His Lys 
225                 230                 235                 240 


Ala Arg Glu Asn Lys Phe Ile Val Arg Asp Phe Gln Tyr Asn Glu Glu 
                245                 250                 255     


Glu Met Lys Ala Asp Lys Glu Glu Met Asn Arg Leu Ser Xaa Asp Lys 
            260                 265                 270         


Lys Lys Gln Phe Gly Pro Leu Val Arg Trp Leu Lys Val Asn Phe Ser 
        275                 280                 285             


Glu Ala Phe Ile Ala Trp Ile His Val Lys Ala Leu Arg Val Phe Val 
    290                 295                 300                 


Glu Ser Val Leu Arg Tyr Gly Leu Pro Val Asn Phe Gln Ala Met Leu 
305                 310                 315                 320 


Leu Gln Pro Asn Lys Lys Xaa Leu Lys Lys Leu Arg Glu Val Leu His 
                325                 330                 335     


Glu Leu Tyr Lys His Leu Asp Ser Ser Ala Ala Ala Ile Ile Asp Ala 
            340                 345                 350         


Pro Met Asp Ile Pro Gly Leu Asn Leu Ser Gln Gln Glu Tyr Tyr Pro 
        355                 360                 365             


Tyr Val Tyr Tyr Lys Ile Asp Cys Asn Leu Leu Glu Phe Lys 
    370                 375                 380         


<210> 3669
<211> 437
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<400> 3669
Met Ser Glu Phe Trp Leu Ile Ser Ala Pro Gly Asp Lys Glu Asn Leu 
1               5                   10                  15      


Gln Ala Leu Glu Arg Met Asn Xaa Val Xaa Ser Lys Ser Asn Leu Ser 
            20                  25                  30          


Tyr Asn Xaa Lys Phe Ala Ile Pro Asp Phe Lys Val Gly Xaa Leu Asp 
        35                  40                  45              


Ser Leu Val Gly Leu Ser Asp Glu Leu Gly Lys Leu Asp Xaa Phe Ala 
    50                  55                  60                  


Glu Ser Leu Ile Arg Arg Met Ala Gln Ser Val Val Glu Val Met Glu 
65                  70                  75                  80  


Asp Ser Lys Gly Lys Val Gln Glu His Leu Leu Ala Asn Gly Gly Leu 
                85                  90                  95      


Lys Gly Lys Met Lys Cys Leu Lys Ile Asp Leu Xaa Ser Phe Val Xaa 
            100                 105                 110         


His Phe Glu Trp Asp Met Ala Lys Tyr Pro Val Lys Gln Pro Leu Val 
        115                 120                 125             


Ser Val Val Asp Xaa Ile Ala Lys Gln Leu Ala Gln Ile Glu Met Asp 
    130                 135                 140                 


Leu Lys Ser Arg Xaa Ala Ala Tyr Asn Xaa Leu Lys Xaa Asn Leu Glu 
145                 150                 155                 160 


Asn Leu Glu Lys Lys Ser Met Gly Asn Leu Phe Xaa Arg Xaa Leu Ser 
                165                 170                 175     


Asp Ile Val Ser Lys Glu Asp Phe Val Leu Asp Ser Glu Tyr Leu Val 
            180                 185                 190         


Xaa Leu Leu Val Ile Val Pro Lys Pro Asn Tyr Ser Gln Trp Gln Lys 
        195                 200                 205             


Xaa Tyr Glu Ser Leu Ser Asp Met Val Val Pro Arg Ser Xaa Lys Leu 
    210                 215                 220                 


Ile Xaa Glu Asp Lys Glu Gly Gly Leu Phe Xaa Val Xaa Leu Phe Arg 
225                 230                 235                 240 


Lys Val Ile Glu Asp Phe Lys Xaa Lys Ala Lys Glu Asn Lys Phe Xaa 
                245                 250                 255     


Val Arg Glu Phe Tyr Tyr Asp Glu Lys Glu Ile Glu Arg Glu Arg Glu 
            260                 265                 270         


Glu Met Ala Arg Leu Leu Ser Asp Lys Lys Gln Gln Tyr Gln Xaa Ser 
        275                 280                 285             


Cys Val Ala Leu Lys Lys Gly Ser Ser Xaa Phe Pro Asp His Lys Val 
    290                 295                 300                 


Lys Val Xaa Pro Leu Gly Asn Pro Asp Arg Pro Ala Ala Gly Gln Xaa 
305                 310                 315                 320 


Asp Arg Glu Arg Glu Ser Glu Gly Glu Gly Glu Gly Pro Leu Leu Arg 
                325                 330                 335     


Trp Leu Lys Val Asn Phe Ser Glu Ala Phe Ile Ala Trp Ile His Ile 
            340                 345                 350         


Lys Ala Leu Arg Val Phe Val Glu Ser Val Leu Arg Tyr Gly Leu Pro 
        355                 360                 365             


Val Asn Phe Gln Ala Val Leu Leu Gln Pro His Lys Lys Ser Ser Xaa 
    370                 375                 380                 


Lys Arg Leu Arg Glu Val Leu Asn Ser Val Phe Arg His Leu Asp Glu 
385                 390                 395                 400 


Val Ala Ala Xaa Ser Ile Leu Asp Ala Ser Val Glu Ile Pro Gly Leu 
                405                 410                 415     


Gln Leu Asn Asn Gln Asp Tyr Phe Pro Tyr Val Tyr Phe His Ile Asp 
            420                 425                 430         


Leu Ser Leu Leu Asp 
        435         


<210> 3670
<211> 381
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<400> 3670
Met Ser Glu Phe Trp Leu Ile Ser Ala Pro Gly Asp Lys Glu Asn Leu 
1               5                   10                  15      


Gln Ala Leu Glu Arg Met Asn Xaa Val Xaa Ser Lys Ser Asn Leu Ser 
            20                  25                  30          


Tyr Asn Xaa Lys Phe Ala Ile Pro Asp Phe Lys Val Gly Xaa Leu Asp 
        35                  40                  45              


Ser Leu Val Gly Leu Ser Asp Glu Leu Gly Lys Leu Asp Xaa Phe Ala 
    50                  55                  60                  


Glu Ser Leu Ile Arg Arg Met Ala Gln Ser Val Val Glu Val Met Glu 
65                  70                  75                  80  


Asp Ser Lys Gly Lys Val Gln Glu His Leu Leu Ala Asn Gly Val Asp 
                85                  90                  95      


Leu Xaa Ser Phe Val Xaa His Phe Glu Trp Asp Met Ala Lys Tyr Pro 
            100                 105                 110         


Val Lys Gln Pro Leu Val Ser Val Val Asp Xaa Ile Ala Lys Gln Leu 
        115                 120                 125             


Ala Gln Ile Glu Met Asp Leu Lys Ser Arg Xaa Ala Ala Tyr Asn Xaa 
    130                 135                 140                 


Leu Lys Xaa Asn Leu Glu Asn Leu Glu Lys Lys Ser Met Gly Asn Leu 
145                 150                 155                 160 


Phe Xaa Arg Xaa Leu Ser Asp Ile Val Ser Lys Glu Asp Phe Val Leu 
                165                 170                 175     


Asp Ser Glu Tyr Leu Val Xaa Leu Leu Val Ile Val Pro Lys Pro Asn 
            180                 185                 190         


Tyr Ser Gln Trp Gln Lys Xaa Tyr Glu Ser Leu Ser Asp Met Val Val 
        195                 200                 205             


Pro Arg Ser Xaa Lys Leu Ile Xaa Glu Asp Lys Glu Gly Gly Leu Phe 
    210                 215                 220                 


Xaa Val Xaa Leu Phe Arg Lys Val Ile Glu Asp Phe Lys Xaa Lys Ala 
225                 230                 235                 240 


Lys Glu Asn Lys Phe Xaa Val Arg Glu Phe Tyr Tyr Asp Glu Lys Glu 
                245                 250                 255     


Ile Glu Arg Glu Arg Glu Glu Met Ala Arg Leu Leu Ser Asp Lys Lys 
            260                 265                 270         


Gln Gln Tyr Gly Pro Leu Leu Arg Trp Leu Lys Val Asn Phe Ser Glu 
        275                 280                 285             


Ala Phe Ile Ala Trp Ile His Ile Lys Ala Leu Arg Val Phe Val Glu 
    290                 295                 300                 


Ser Val Leu Arg Tyr Gly Leu Pro Val Asn Phe Gln Ala Val Leu Leu 
305                 310                 315                 320 


Gln Pro His Lys Lys Ser Ser Xaa Lys Arg Leu Arg Glu Val Leu Asn 
                325                 330                 335     


Ser Val Phe Arg His Leu Asp Glu Val Ala Ala Xaa Ser Ile Leu Asp 
            340                 345                 350         


Ala Ser Val Glu Ile Pro Gly Leu Gln Leu Asn Asn Gln Asp Tyr Phe 
        355                 360                 365             


Pro Tyr Val Tyr Phe His Ile Asp Leu Ser Leu Leu Asp 
    370                 375                 380     


<210> 3671
<211> 427
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<400> 3671
Met Ser Glu Phe Trp Leu Ile Ser Ala Pro Gly Asp Lys Glu Asn Leu 
1               5                   10                  15      


Gln Ala Leu Glu Arg Met Asn Xaa Val Xaa Ser Lys Ser Asn Leu Ser 
            20                  25                  30          


Tyr Asn Xaa Lys Phe Ala Ile Pro Asp Phe Lys Val Gly Xaa Leu Asp 
        35                  40                  45              


Ser Leu Val Gly Leu Ser Asp Glu Leu Gly Lys Leu Asp Xaa Phe Ala 
    50                  55                  60                  


Glu Ser Leu Ile Arg Arg Met Ala Gln Ser Val Val Glu Val Met Glu 
65                  70                  75                  80  


Asp Ser Lys Gly Lys Val Gln Glu His Leu Leu Ala Asn Gly Val Asp 
                85                  90                  95      


Leu Xaa Ser Phe Val Xaa His Phe Glu Trp Asp Met Ala Lys Tyr Pro 
            100                 105                 110         


Val Lys Gln Pro Leu Val Ser Val Val Asp Xaa Ile Ala Lys Gln Leu 
        115                 120                 125             


Ala Gln Ile Glu Met Asp Leu Lys Ser Arg Xaa Ala Ala Tyr Asn Xaa 
    130                 135                 140                 


Leu Lys Xaa Asn Leu Glu Asn Leu Glu Lys Lys Ser Met Gly Asn Leu 
145                 150                 155                 160 


Phe Xaa Arg Xaa Leu Ser Asp Ile Val Ser Lys Glu Asp Phe Val Leu 
                165                 170                 175     


Asp Ser Glu Tyr Leu Val Xaa Leu Leu Val Ile Val Pro Lys Pro Asn 
            180                 185                 190         


Tyr Ser Gln Trp Gln Lys Xaa Tyr Glu Ser Leu Ser Asp Met Val Val 
        195                 200                 205             


Pro Arg Ser Xaa Lys Leu Ile Xaa Glu Asp Lys Glu Gly Gly Leu Phe 
    210                 215                 220                 


Xaa Val Xaa Leu Phe Arg Lys Val Ile Glu Asp Phe Lys Xaa Lys Ala 
225                 230                 235                 240 


Lys Glu Asn Lys Phe Xaa Val Arg Glu Phe Tyr Tyr Asp Glu Lys Glu 
                245                 250                 255     


Ile Glu Arg Glu Arg Glu Glu Met Ala Arg Leu Leu Ser Asp Lys Lys 
            260                 265                 270         


Gln Gln Tyr Gln Xaa Ser Cys Val Ala Leu Lys Lys Gly Ser Ser Xaa 
        275                 280                 285             


Phe Pro Asp His Lys Val Lys Val Xaa Pro Leu Gly Asn Pro Asp Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gln Xaa Asp Arg Glu Arg Glu Ser Glu Gly Glu Gly 
305                 310                 315                 320 


Glu Gly Pro Leu Leu Arg Trp Leu Lys Val Asn Phe Ser Glu Ala Phe 
                325                 330                 335     


Ile Ala Trp Ile His Ile Lys Ala Leu Arg Val Phe Val Glu Ser Val 
            340                 345                 350         


Leu Arg Tyr Gly Leu Pro Val Asn Phe Gln Ala Val Leu Leu Gln Pro 
        355                 360                 365             


His Lys Lys Ser Ser Xaa Lys Arg Leu Arg Glu Val Leu Asn Ser Val 
    370                 375                 380                 


Phe Arg His Leu Asp Glu Val Ala Ala Xaa Ser Ile Leu Asp Ala Ser 
385                 390                 395                 400 


Val Glu Ile Pro Gly Leu Gln Leu Asn Asn Gln Asp Tyr Phe Pro Tyr 
                405                 410                 415     


Val Tyr Phe His Ile Asp Leu Ser Leu Leu Asp 
            420                 425         


<210> 3672
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<400> 3672
Lys Lys Ile Ile Glu Xaa Lys Met Leu Met Gly Glu Val Met Arg Glu 
1               5                   10                  15      


Ala Ala Phe Ser Leu Ala Glu Ala Lys Phe Xaa Ala Gly Asp Phe Ser 
            20                  25                  30          


Xaa Xaa Val Ile Gln Asn Val Asn Lys Ala Gln Val Lys Ile Arg Ala 
        35                  40                  45              


Lys Lys Asp Asn Val Ala Gly Val Xaa Leu Pro Val Phe Glu His Tyr 
    50                  55                  60                  


His Glu Gly Xaa Asp Ser Tyr Glu Leu Xaa Gly Leu Ala Arg Gly Gly 
65                  70                  75                  80  


Glu Gln Leu Ala Lys Leu Lys Arg Asn Tyr Ala Lys Ala Val Glu Leu 
                85                  90                  95      


Leu Val Glu Leu Ala Ser Leu Gln Val Lys Glu Asn Xaa Arg Glu Glu 
            100                 105                 110         


Lys Asp Ser Lys Gly Lys Ile 
        115                 


<210> 3673
<211> 59
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<400> 3673
Met Lys Ala Arg Leu Lys Gly Ala Gln Xaa Gly Arg Asn Leu Leu Lys 
1               5                   10                  15      


Lys Lys Ser Asp Ala Leu Xaa Leu Arg Phe Arg Gln Ile Leu Lys Lys 
            20                  25                  30          


Ile Ile Glu Xaa Lys Met Leu Met Gly Glu Val Met Arg Glu Ala Ala 
        35                  40                  45              


Phe Ser Leu Ala Glu Ala Lys Phe Xaa Ala Gly 
    50                  55                  


<210> 3674
<211> 192
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<400> 3674
Met Leu Met Gly Glu Val Met Arg Glu Ala Ala Phe Ser Leu Ala Glu 
1               5                   10                  15      


Ala Lys Phe Xaa Ala Gly Asp Phe Ser Xaa Xaa Val Ile Gln Asn Val 
            20                  25                  30          


Asn Lys Ala Gln Val Lys Ile Arg Ala Lys Lys Asp Asn Val Ala Gly 
        35                  40                  45              


Val Xaa Leu Pro Val Phe Glu His Tyr His Glu Gly Xaa Asp Ser Tyr 
    50                  55                  60                  


Glu Leu Xaa Gly Leu Ala Arg Gly Gly Glu Gln Leu Ala Lys Leu Lys 
65                  70                  75                  80  


Arg Asn Tyr Ala Lys Ala Val Glu Leu Leu Val Glu Leu Ala Ser Leu 
                85                  90                  95      


Gln Xaa Ser Phe Val Xaa Leu Asp Glu Ala Ile Lys Ile Xaa Asn Arg 
            100                 105                 110         


Arg Val Asn Ala Ile Glu His Val Ile Ile Pro Arg Ile Glu Arg Xaa 
        115                 120                 125             


Leu Ala Tyr Ile Ile Xaa Glu Leu Asp Glu Arg Glu Arg Glu Glu Phe 
    130                 135                 140                 


Tyr Arg Leu Lys Lys Ile Gln Glu Lys Lys Lys Ile Leu Lys Glu Lys 
145                 150                 155                 160 


Ser Glu Lys Asp Leu Glu Gln Arg Arg Ala Ala Gly Glu Val Leu Glu 
                165                 170                 175     


Pro Ala Asn Leu Leu Ala Glu Glu Lys Asp Glu Asp Leu Leu Phe Glu 
            180                 185                 190         


<210> 3675
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<400> 3675
Met Ser Gly Lys Asp Arg Ile Glu Ile Phe Pro Ser Arg Met Ala Gln 
1               5                   10                  15      


Xaa Ile Met Lys Ala Arg Leu Lys Gly Ala Gln Xaa Gly Arg Asn Leu 
            20                  25                  30          


Leu Lys Lys Lys Ser Asp Ala Leu Xaa Leu Arg Phe Arg Gln Ile Leu 
        35                  40                  45              


Lys Lys Ile Ile Glu Xaa Lys Met Leu Met Gly Glu Val Met Arg Glu 
    50                  55                  60                  


Ala Ala Phe Ser Leu Ala Glu Ala 
65                  70          


<210> 3676
<211> 86
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<400> 3676
Met Ser Gly Lys Asp Arg Ile Glu Ile Phe Pro Ser Arg Met Ala Gln 
1               5                   10                  15      


Xaa Ile Met Lys Ala Arg Leu Lys Gly Ala Gln Xaa Gly Arg Asn Leu 
            20                  25                  30          


Leu Lys Lys Lys Ser Asp Ala Leu Xaa Leu Arg Phe Arg Gln Ile Leu 
        35                  40                  45              


Lys Lys Ile Ile Glu Xaa Lys Met Leu Met Gly Glu Val Met Arg Glu 
    50                  55                  60                  


Ala Ala Phe Ser Leu Ala Glu Ala Lys Phe Xaa Ala Gly Asp Phe Arg 
65                  70                  75                  80  


Cys Tyr Phe Ala Ser Ile 
                85      


<210> 3677
<211> 179
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<400> 3677
Met Ser Gly Lys Asp Arg Ile Glu Ile Phe Pro Ser Arg Met Ala Gln 
1               5                   10                  15      


Xaa Ile Met Lys Ala Arg Leu Lys Gly Ala Gln Xaa Gly Arg Asn Leu 
            20                  25                  30          


Leu Lys Lys Lys Ser Asp Ala Leu Xaa Leu Arg Phe Arg Gln Ile Leu 
        35                  40                  45              


Lys Lys Ile Ile Glu Xaa Lys Met Leu Met Gly Glu Val Met Arg Glu 
    50                  55                  60                  


Ala Ala Phe Ser Leu Ala Glu Ala Lys Phe Xaa Ala Gly Asp Phe Ser 
65                  70                  75                  80  


Xaa Xaa Val Ile Gln Asn Val Asn Lys Ala Gln Val Lys Ile Arg Ala 
                85                  90                  95      


Lys Lys Asp Asn Val Ala Gly Val Xaa Leu Pro Val Phe Glu His Tyr 
            100                 105                 110         


His Glu Gly Xaa Asp Ser Tyr Glu Leu Xaa Gly Leu Ala Arg Gly Gly 
        115                 120                 125             


Glu Gln Leu Ala Lys Leu Lys Arg Asn Tyr Ala Lys Ala Val Glu Leu 
    130                 135                 140                 


Leu Val Glu Leu Ala Ser Leu Gln Ser Ser Phe Pro Gly Leu Asn Val 
145                 150                 155                 160 


Leu Leu Leu Ile Ser Ser Gln Ser Trp Met Arg Glu Ser Glu Lys Ser 
                165                 170                 175     


Ser Ile Gly 
            


<210> 3678
<211> 247
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<400> 3678
Met Ser Gly Lys Asp Arg Ile Glu Ile Phe Pro Ser Arg Met Ala Gln 
1               5                   10                  15      


Xaa Ile Met Lys Ala Arg Leu Lys Gly Ala Gln Xaa Gly Arg Asn Leu 
            20                  25                  30          


Leu Lys Lys Lys Ser Asp Ala Leu Xaa Leu Arg Phe Arg Gln Ile Leu 
        35                  40                  45              


Lys Lys Ile Ile Glu Xaa Lys Met Leu Met Gly Glu Val Met Arg Glu 
    50                  55                  60                  


Ala Ala Phe Ser Leu Ala Glu Ala Lys Phe Xaa Ala Gly Asp Phe Ser 
65                  70                  75                  80  


Xaa Xaa Val Ile Gln Asn Val Asn Lys Ala Gln Val Lys Ile Arg Ala 
                85                  90                  95      


Lys Lys Asp Asn Val Ala Gly Val Xaa Leu Pro Val Phe Glu His Tyr 
            100                 105                 110         


His Glu Gly Xaa Asp Ser Tyr Glu Leu Xaa Gly Leu Ala Arg Gly Gly 
        115                 120                 125             


Glu Gln Leu Ala Lys Leu Lys Arg Asn Tyr Ala Lys Ala Val Glu Leu 
    130                 135                 140                 


Leu Val Glu Leu Ala Ser Leu Gln Xaa Ser Phe Val Xaa Leu Asp Glu 
145                 150                 155                 160 


Ala Ile Lys Ile Xaa Asn Arg Arg Val Asn Ala Ile Glu His Val Ile 
                165                 170                 175     


Ile Pro Arg Ile Glu Arg Xaa Leu Ala Tyr Ile Ile Xaa Glu Leu Asp 
            180                 185                 190         


Glu Arg Glu Arg Glu Glu Phe Tyr Arg Leu Lys Lys Ile Gln Glu Lys 
        195                 200                 205             


Lys Lys Ile Leu Lys Glu Lys Ser Glu Lys Asp Leu Glu Gln Arg Arg 
    210                 215                 220                 


Ala Ala Gly Glu Val Leu Glu Pro Ala Asn Leu Leu Ala Glu Glu Lys 
225                 230                 235                 240 


Asp Glu Asp Leu Leu Phe Glu 
                245         


<210> 3679
<211> 148
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<400> 3679
Met Ser Gly Lys Asp Arg Ile Glu Ile Phe Pro Ser Arg Met Ala Gln 
1               5                   10                  15      


Xaa Ile Met Lys Ala Arg Leu Lys Gly Ala Gln Xaa Gly Arg Asn Leu 
            20                  25                  30          


Leu Lys Lys Lys Ser Asp Ala Leu Xaa Leu Arg Phe Arg Gln Ile Leu 
        35                  40                  45              


Lys Lys Ile Ile Glu Xaa Ser Phe Val Xaa Leu Asp Glu Ala Ile Lys 
    50                  55                  60                  


Ile Xaa Asn Arg Arg Val Asn Ala Ile Glu His Val Ile Ile Pro Arg 
65                  70                  75                  80  


Ile Glu Arg Xaa Leu Ala Tyr Ile Ile Xaa Glu Leu Asp Glu Arg Glu 
                85                  90                  95      


Arg Glu Glu Phe Tyr Arg Leu Lys Lys Ile Gln Glu Lys Lys Lys Ile 
            100                 105                 110         


Leu Lys Glu Lys Ser Glu Lys Asp Leu Glu Gln Arg Arg Ala Ala Gly 
        115                 120                 125             


Glu Val Leu Glu Pro Ala Asn Leu Leu Ala Glu Glu Lys Asp Glu Asp 
    130                 135                 140                 


Leu Leu Phe Glu 
145             


<210> 3680
<211> 153
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 3680
Arg Ala Lys Lys Asp Asn Val Ala Gly Val Xaa Leu Pro Val Phe Glu 
1               5                   10                  15      


His Tyr His Glu Gly Xaa Asp Ser Tyr Glu Leu Xaa Gly Leu Ala Arg 
            20                  25                  30          


Gly Gly Glu Gln Leu Ala Lys Leu Lys Arg Asn Tyr Ala Lys Ala Val 
        35                  40                  45              


Glu Leu Leu Val Glu Leu Ala Ser Leu Gln Xaa Ser Phe Val Xaa Leu 
    50                  55                  60                  


Asp Glu Ala Ile Lys Ile Xaa Asn Arg Arg Val Asn Ala Ile Glu His 
65                  70                  75                  80  


Val Ile Ile Pro Arg Ile Glu Arg Xaa Leu Ala Tyr Ile Ile Xaa Glu 
                85                  90                  95      


Leu Asp Glu Arg Glu Arg Glu Glu Phe Tyr Arg Leu Lys Lys Ile Gln 
            100                 105                 110         


Glu Lys Lys Lys Ile Leu Lys Glu Lys Ser Glu Lys Asp Leu Glu Gln 
        115                 120                 125             


Arg Arg Ala Ala Gly Glu Val Leu Glu Pro Ala Asn Leu Leu Ala Glu 
    130                 135                 140                 


Glu Lys Asp Glu Asp Leu Leu Phe Glu 
145                 150             


<210> 3681
<211> 44
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(22)
<223> Selenocysteine

<400> 3681
Val Met Arg Glu Ala Ala Phe Ser Leu Ala Glu Ala Lys Phe Xaa Ala 
1               5                   10                  15      


Gly Asp Phe Ser Xaa Xaa Val Ile Gln Asn Val Asn Lys Ala Gln Val 
            20                  25                  30          


Lys Ile Arg Ala Lys Lys Asp Asn Val Ala Ala Cys 
        35                  40                  


<210> 3682
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 3682
Met Ala Leu Ser Asp Ala Asp Val Gln Lys Gln Ala Glu Glu Glu Phe 
1               5                   10                  15      


Asn Ile Glu Lys Gly Arg Leu Val Gln Xaa Gln Arg Leu Lys Ile Met 
            20                  25                  30          


Glu Tyr Tyr Glu Lys Lys Glu Lys Gln Ile Glu Gln Gln Lys Lys Ile 
        35                  40                  45              


Gln Met Ser Asn Leu Met Asn Gln Ala Arg Leu Lys Val Leu Arg Ala 
    50                  55                  60                  


Arg Asp Asp Leu Ile Xaa Asp Leu Leu Asn Glu Ala Lys Gln Arg Leu 
65                  70                  75                  80  


Ser Lys Val Val Lys Asp Xaa Xaa Arg Tyr Gln Val Leu Leu Asp Gly 
                85                  90                  95      


Leu Val Leu Gln Gly Leu Tyr Gln Leu Leu Glu Pro Arg Met Ile Val 
            100                 105                 110         


Arg Cys Arg Lys Gln Asp Phe Pro Leu Val Lys Ala Ala Val Gln Lys 
        115                 120                 125             


Ala Ile Pro Met Tyr Lys Ile Ala Xaa Lys Asn Asp Val Asp Val Gln 
    130                 135                 140                 


Ile Asp Gln Glu Ser Tyr Leu Pro Glu Asp Ile Ala Gly Gly Val Glu 
145                 150                 155                 160 


Ile Tyr Asn Gly Asp Arg Lys Ile Lys Val Ser Asn Xaa Leu Glu Ser 
                165                 170                 175     


Arg Leu Asp Leu Ile Ala Gln Gln Met Met Pro Glu Val Arg Gly Ala 
            180                 185                 190         


Leu Phe Gly Ala Asn Ala Asn Arg Lys Phe Leu Asp 
        195                 200                 


<210> 3683
<211> 226
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<400> 3683
Met Ala Leu Ser Asp Ala Asp Val Gln Lys Gln Ile Lys His Met Met 
1               5                   10                  15      


Ala Phe Ile Glu Gln Glu Ala Asn Glu Lys Ala Glu Glu Ile Asp Ala 
            20                  25                  30          


Lys Ala Glu Glu Glu Phe Asn Ile Glu Lys Gly Arg Leu Val Gln Xaa 
        35                  40                  45              


Gln Arg Leu Lys Ile Met Glu Tyr Tyr Glu Lys Lys Glu Lys Gln Ile 
    50                  55                  60                  


Glu Gln Gln Lys Lys Ile Gln Met Ser Asn Leu Met Asn Gln Ala Arg 
65                  70                  75                  80  


Leu Lys Val Leu Arg Ala Arg Asp Asp Leu Ile Xaa Asp Leu Leu Asn 
                85                  90                  95      


Glu Ala Lys Gln Arg Leu Ser Lys Val Val Lys Asp Xaa Xaa Arg Tyr 
            100                 105                 110         


Gln Val Leu Leu Asp Gly Leu Val Leu Gln Gly Leu Tyr Gln Leu Leu 
        115                 120                 125             


Glu Pro Arg Met Ile Val Arg Cys Arg Lys Gln Asp Phe Pro Leu Val 
    130                 135                 140                 


Lys Ala Ala Val Gln Lys Ala Ile Pro Met Tyr Lys Ile Ala Xaa Lys 
145                 150                 155                 160 


Asn Asp Val Asp Val Gln Ile Asp Gln Glu Ser Tyr Leu Pro Glu Asp 
                165                 170                 175     


Ile Ala Gly Gly Val Glu Ile Tyr Asn Gly Asp Arg Lys Ile Lys Val 
            180                 185                 190         


Ser Asn Xaa Leu Glu Ser Arg Leu Asp Leu Ile Ala Gln Gln Met Met 
        195                 200                 205             


Pro Glu Val Arg Gly Ala Leu Phe Gly Ala Asn Ala Asn Arg Lys Phe 
    210                 215                 220                 


Leu Asp 
225     


<210> 3684
<211> 196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 3684
Met Ala Leu Ser Asp Ala Asp Val Gln Lys Gln Ile Lys His Met Met 
1               5                   10                  15      


Ala Phe Ile Glu Gln Glu Ala Asn Glu Lys Ala Glu Glu Ile Asp Ala 
            20                  25                  30          


Lys Ala Glu Glu Glu Phe Asn Ile Glu Lys Gly Arg Leu Val Gln Xaa 
        35                  40                  45              


Gln Arg Leu Lys Ile Met Glu Tyr Tyr Glu Lys Lys Glu Lys Gln Ile 
    50                  55                  60                  


Glu Gln Gln Lys Lys Ile Gln Met Ser Asn Leu Met Asn Gln Ala Arg 
65                  70                  75                  80  


Leu Lys Val Leu Arg Ala Arg Asp Asp Leu Ile Xaa Gly Leu Tyr Gln 
                85                  90                  95      


Leu Leu Glu Pro Arg Met Ile Val Arg Cys Arg Lys Gln Asp Phe Pro 
            100                 105                 110         


Leu Val Lys Ala Ala Val Gln Lys Ala Ile Pro Met Tyr Lys Ile Ala 
        115                 120                 125             


Xaa Lys Asn Asp Val Asp Val Gln Ile Asp Gln Glu Ser Tyr Leu Pro 
    130                 135                 140                 


Glu Asp Ile Ala Gly Gly Val Glu Ile Tyr Asn Gly Asp Arg Lys Ile 
145                 150                 155                 160 


Lys Val Ser Asn Xaa Leu Glu Ser Arg Leu Asp Leu Ile Ala Gln Gln 
                165                 170                 175     


Met Met Pro Glu Val Arg Gly Ala Leu Phe Gly Ala Asn Ala Asn Arg 
            180                 185                 190         


Lys Phe Leu Asp 
        195     


<210> 3685
<211> 203
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<400> 3685
Met Gln Ser Arg Asp Gly Val Ser Pro Cys Trp Pro Gly Trp Ser Gln 
1               5                   10                  15      


Ser Leu Asp Leu Val Ile Arg Leu Pro Arg Pro Pro Gln Val Leu Gly 
            20                  25                  30          


Leu Gln Ala Glu Glu Glu Phe Asn Ile Glu Lys Gly Arg Leu Val Gln 
        35                  40                  45              


Xaa Gln Arg Leu Lys Ile Met Glu Tyr Tyr Glu Lys Lys Glu Lys Gln 
    50                  55                  60                  


Ile Glu Gln Gln Lys Lys Ile Gln Met Ser Asn Leu Met Asn Gln Ala 
65                  70                  75                  80  


Arg Leu Lys Val Leu Arg Ala Arg Asp Asp Leu Ile Xaa Asp Leu Leu 
                85                  90                  95      


Asn Glu Ala Lys Gln Arg Leu Ser Lys Val Val Lys Asp Xaa Xaa Arg 
            100                 105                 110         


Tyr Gln Val Leu Leu Asp Gly Leu Val Leu Gln Gly Leu Tyr Gln Leu 
        115                 120                 125             


Leu Glu Pro Arg Met Ile Val Arg Cys Arg Lys Gln Asp Phe Pro Leu 
    130                 135                 140                 


Val Lys Ala Ala Val Gln Lys Ala Ile Pro Met Tyr Lys Ile Ala Xaa 
145                 150                 155                 160 


Lys Asn Asp Val Asp Val Gln Ile Asp Gln Glu Ser Tyr Leu Pro Glu 
                165                 170                 175     


Asp Ile Ala Gly Gly Val Glu Ile Tyr Asn Gly Asp Arg Lys Ile Lys 
            180                 185                 190         


Val Ser Asn Xaa Leu Glu Ser Arg Leu Asp Leu 
        195                 200             


<210> 3686
<211> 226
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<400> 3686
Met Ala Leu Ser Asp Val Asp Val Lys Lys Gln Ile Lys His Met Met 
1               5                   10                  15      


Ala Phe Ile Glu Gln Glu Ala Asn Glu Lys Ala Glu Glu Ile Asp Ala 
            20                  25                  30          


Lys Ala Glu Glu Glu Phe Asn Ile Glu Lys Gly Arg Leu Val Gln Xaa 
        35                  40                  45              


Gln Arg Leu Lys Ile Met Glu Tyr Tyr Glu Lys Lys Glu Lys Gln Ile 
    50                  55                  60                  


Glu Gln Gln Lys Lys Ile Leu Met Ser Xaa Met Arg Asn Gln Ala Arg 
65                  70                  75                  80  


Leu Lys Val Leu Arg Ala Arg Asn Asp Leu Ile Ser Asp Leu Leu Ser 
                85                  90                  95      


Glu Ala Lys Leu Arg Leu Ser Arg Ile Val Glu Asp Pro Glu Val Tyr 
            100                 105                 110         


Gln Gly Leu Leu Asp Lys Leu Val Leu Gln Gly Leu Leu Arg Leu Leu 
        115                 120                 125             


Glu Pro Val Met Ile Val Arg Cys Arg Pro Gln Asp Leu Leu Leu Val 
    130                 135                 140                 


Glu Ala Ala Val Gln Lys Ala Ile Pro Glu Tyr Met Xaa Ile Ser Gln 
145                 150                 155                 160 


Lys His Val Glu Val Gln Ile Asp Lys Glu Ala Tyr Leu Ala Val Asn 
                165                 170                 175     


Ala Ala Gly Gly Val Glu Val Tyr Ser Gly Asn Gln Arg Ile Lys Val 
            180                 185                 190         


Ser Asn Xaa Leu Glu Ser Arg Leu Asp Leu Ser Ala Lys Gln Lys Met 
        195                 200                 205             


Pro Glu Ile Arg Met Ala Leu Phe Gly Ala Asn Xaa Asn Arg Lys Phe 
    210                 215                 220                 


Phe Ile 
225     


<210> 3687
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<400> 3687
Met Ala Gly Arg Gly Lys Leu Ile Ala Val Ile Gly Asp Glu Asp Xaa 
1               5                   10                  15      


Val Xaa Gly Phe Leu Leu Gly Gly Ile Gly Glu Leu Asn Lys Asn Arg 
            20                  25                  30          


His Pro Asn Phe Leu Val Val Glu Lys Asp Xaa Xaa Ile Asn Glu Ile 
        35                  40                  45              


Glu Asp Xaa Phe Arg Gln Phe Leu Asn Arg Asp Asp Ile Gly Ile Ile 
    50                  55                  60                  


Leu Ile Asn Gln Tyr Ile Ala Glu Met Val Arg His Ala Leu Asp Ala 
65                  70                  75                  80  


His Gln Gln Ser Ile Pro Ala Val Leu Glu Ile Pro Ser Lys Glu His 
                85                  90                  95      


Pro Tyr Asp Ala Ala Lys Asp Ser Ile Leu Arg Arg Ala Arg Gly Met 
            100                 105                 110         


Phe Xaa Ala Glu Asp Leu Arg 
        115                 


<210> 3688
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<400> 3688
Met Ala Gly Arg Gly Lys Leu Ile Ala Val Ile Gly Asp Glu Asp Xaa 
1               5                   10                  15      


Val Xaa Gly Phe Leu Leu Gly Gly Ile Gly Glu Leu Asn Lys Asn Arg 
            20                  25                  30          


His Pro Asn Phe Leu Val Val Glu Lys Asp Xaa Xaa Ile Asn Glu Ile 
        35                  40                  45              


Glu Asp Xaa Phe Arg Ser Leu Gly Ser Leu Pro Gly Ser Val Val Glu 
    50                  55                  60                  


Ala Asn Pro Asn Gln Arg Asp Pro Pro Leu Trp Asp Glu Ile Asp Ser 
65                  70                  75                  80  


Arg Gln Phe Leu Asn Arg Asp Asp Ile Gly Ile Ile Leu Ile Asn Gln 
                85                  90                  95      


Tyr Ile Ala Glu Met Val Arg His Ala Leu Asp Ala His Gln Gln Ser 
            100                 105                 110         


Ile Pro Ala Val Leu Glu Ile Pro Ser Lys Glu His Pro Tyr Asp Ala 
        115                 120                 125             


Ala Lys Asp Ser Ile Leu Arg Arg Ala Arg Gly Met Phe Xaa Ala Glu 
    130                 135                 140                 


Asp Leu Arg 
145         


<210> 3689
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 3689
Met Ala Ser Gln Ser Gln Gly Ile Gln Gln Leu Leu Gln Ala Glu Lys 
1               5                   10                  15      


Arg Ala Ala Glu Lys Val Ser Glu Ala Arg Lys Arg Lys Asn Arg Arg 
            20                  25                  30          


Leu Lys Gln Ala Lys Glu Glu Ala Gln Ala Glu Ile Glu Gln Tyr Arg 
        35                  40                  45              


Leu Gln Arg Glu Lys Glu Phe Lys Ala Lys Glu Ala Ala Ala Leu Gly 
    50                  55                  60                  


Ser Arg Gly Ser Cys Ser Xaa Glu Val Glu Lys Glu Xaa Gln Glu Lys 
65                  70                  75                  80  


Met Xaa Ile Leu Gln Xaa Tyr Phe Arg Gln Asn Arg Asp Glu Val Leu 
                85                  90                  95      


Asp Asn Leu Leu Ala Phe Val Cys Asp Ile Arg Pro Glu Ile His Glu 
            100                 105                 110         


Asn Tyr Arg Ile Asn Gly 
        115             


<210> 3690
<211> 158
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 3690
Gly Gly Gln Gln His Ala Val Pro Cys Pro His Gly Gly Pro Gly Gly 
1               5                   10                  15      


Gln Gly Gln Pro Arg Ala Glu Ala Ala Gly Xaa Gly Gln Gly His Arg 
            20                  25                  30          


Gly Gly His Arg Pro Gly Ala Val Val Gly Ala Ala Gln His Leu His 
        35                  40                  45              


Arg Gly Leu Gly Val Ala Gly Gly Gly Pro Gly Pro Gly Pro Ala Val 
    50                  55                  60                  


Leu Gln Xaa Arg Lys Ala Arg Arg Leu Lys Gln Ala Lys Glu Glu Ala 
65                  70                  75                  80  


Gln Met Glu Val Glu Gln Tyr Arg Arg Glu Arg Glu His Glu Phe Gln 
                85                  90                  95      


Ser Lys Gln Gln Ala Ala Met Gly Ser Gln Gly Asn Leu Ser Ala Glu 
            100                 105                 110         


Val Glu Gln Ala Xaa Arg Arg Gln Val Gln Gly Met Gln Ser Ser Gln 
        115                 120                 125             


Gln Arg Asn Arg Glu Arg Val Leu Ala Gln Leu Leu Gly Met Val Cys 
    130                 135                 140                 


Asp Val Arg Pro Gln Val His Pro Asn Tyr Arg Ile Ser Ala 
145                 150                 155             


<210> 3691
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<400> 3691
Met Ala Ser Gln Ser Gln Gly Ile Gln Gln Leu Leu Gln Ala Glu Lys 
1               5                   10                  15      


Arg Ala Ala Glu Lys Val Ala Asp Ala Arg Lys Arg Lys Ala Arg Arg 
            20                  25                  30          


Leu Lys Gln Ala Lys Glu Glu Ala Gln Met Glu Val Glu Gln Tyr Arg 
        35                  40                  45              


Arg Glu Arg Glu His Glu Phe Gln Ser Lys Gln Gln Ala Ala Met Gly 
    50                  55                  60                  


Ser Gln Gly Asn Leu Ser Ala Glu Val Glu Gln Ala Xaa Arg Arg Gln 
65                  70                  75                  80  


Val Gln Gly Met Gln Ser Ser Gln Gln Arg Asn Arg Glu Arg Val Leu 
                85                  90                  95      


Ala Gln Leu Leu Gly Met Val Cys Asp Val Arg Pro Gln Val His Pro 
            100                 105                 110         


Asn Tyr Arg Ile Ser Ala 
        115             


<210> 3692
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<400> 3692
Met Ala Ser Gln Ser Gln Gly Ile Gln Gln Leu Leu Gln Ala Glu Lys 
1               5                   10                  15      


Arg Ala Ala Glu Lys Val Ala Asp Ala Arg Lys Arg Lys Ala Arg Arg 
            20                  25                  30          


Leu Lys Gln Ala Xaa Arg Arg Gln Val Gln Gly Met Gln Ser Ser Gln 
        35                  40                  45              


Gln Arg Asn Arg Glu Arg Val Leu Ala Gln Leu Leu Gly Met Val Cys 
    50                  55                  60                  


Asp Val Arg Pro Gln Val His Pro Asn Tyr Arg Ile Ser Ala 
65                  70                  75              


<210> 3693
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<400> 3693
Met Glu Val Glu Gln Tyr Arg Arg Glu Arg Glu His Glu Phe Gln Ser 
1               5                   10                  15      


Lys Gln Gln Ala Ala Met Gly Ser Gln Gly Asn Leu Ser Ala Glu Val 
            20                  25                  30          


Glu Gln Ala Xaa Arg Arg Gln Val Gln Gly Met Gln Ser Ser Gln Gln 
        35                  40                  45              


Arg Asn Arg Glu Arg Val Leu Ala Gln Leu Leu Gly Met Val Cys Asp 
    50                  55                  60                  


Val Arg Pro Gln Val His Pro Asn Tyr Arg Ile Ser Ala 
65                  70                  75          


<210> 3694
<211> 59
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<400> 3694
Met Xaa Ser Gln Ser Gln Gly Ile His Gln Leu Leu Gln Ala Glu Lys 
1               5                   10                  15      


Arg Ala Lys Asp Lys Leu Glu Glu Ala Lys Lys Ile Leu His Leu Leu 
            20                  25                  30          


Phe Leu Lys Arg Arg Asp Trp Asp Cys Phe Trp Lys Arg Lys Ala Ile 
        35                  40                  45              


Glu Ala Ser Gln Gly Gly Ser Asn Gly Arg Asn 
    50                  55                  


<210> 3695
<211> 124
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<400> 3695
Met Xaa Ser Gln Ser Gln Gly Ile His Gln Leu Leu Gln Ala Glu Lys 
1               5                   10                  15      


Arg Ala Lys Asp Lys Leu Glu Glu Ala Lys Lys Lys Xaa Gly Xaa Ala 
            20                  25                  30          


Ser Gly Lys Gly Lys Arg Leu Lys Gln Ala Lys Glu Glu Ala Met Val 
        35                  40                  45              


Glu Ile Asp Gln Tyr Arg Met Gln Arg Asp Lys Glu Phe Arg Leu Lys 
    50                  55                  60                  


Gln Ser Lys Ile Met Gly Ser Gln Asn Asn Leu Ser Asp Glu Ile Glu 
65                  70                  75                  80  


Glu Gln Xaa Leu Gly Lys Ile Gln Glu Leu Asn Gly His Tyr Asn Lys 
                85                  90                  95      


Tyr Met Glu Ser Val Met Asn Gln Leu Leu Ser Met Val Cys Asp Met 
            100                 105                 110         


Lys Pro Glu Ile His Val Asn Tyr Arg Ala Xaa Asn 
        115                 120                 


<210> 3696
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 3696
Met Xaa Ser Gln Ser Gln Gly Ile His Gln Leu Leu Gln Ala Glu Lys 
1               5                   10                  15      


Arg Ala Lys Asp Lys Leu Glu Glu Ala Lys Lys Arg Lys Gly Lys Arg 
            20                  25                  30          


Leu Lys Gln Ala Lys Glu Glu Ala Met Val Glu Ile Asp Gln Tyr Arg 
        35                  40                  45              


Met Gln Arg Asp Lys Glu Phe Arg Leu Lys Gln Ser Lys Ile Met Gly 
    50                  55                  60                  


Ser Gln Asn Asn Leu Ser Asp Glu Ile Glu Glu Gln Xaa Leu Gly Lys 
65                  70                  75                  80  


Ile Gln Glu Leu Asn Gly His Tyr Asn Lys Tyr Met Glu Ser Val Met 
                85                  90                  95      


Asn Gln Leu Leu Ser Met Val Cys Asp Met Lys Pro Glu Ile His Val 
            100                 105                 110         


Asn Tyr Arg Ala Xaa Asn 
        115             


<210> 3697
<211> 86
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<400> 3697
Phe Asp Tyr Ala Arg Cys Ser Lys Asn Xaa Ala Trp Pro Tyr Phe Leu 
1               5                   10                  15      


Pro Met Leu Asn Arg Gln Asp Pro Phe Xaa Val His Met Ala Ala Arg 
            20                  25                  30          


Ile Ile Ala Lys Leu Ala Ala Trp Gly Lys Glu Leu Met Glu Gly Ser 
        35                  40                  45              


Asp Leu Asn Tyr Tyr Phe Asn Trp Ile Lys Xaa Gln Leu Ser Ser Gln 
    50                  55                  60                  


Lys Leu Arg Gly Ser Gly Val Ala Val Glu Xaa Gly Xaa Val Ser Ser 
65                  70                  75                  80  


Ser Asp His Ser Ile Gln 
                85      


<210> 3698
<211> 443
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<400> 3698
Met Ile Ser Ala Glu Asp Cys Glu Phe Ile Gln Arg Phe Glu Met Lys 
1               5                   10                  15      


Arg Ser Pro Glu Glu Lys Gln Glu Met Leu Gln Xaa Glu Gly Ser Gln 
            20                  25                  30          


Cys Ala Lys Xaa Phe Ile Asn Leu Met Xaa His Ile Cys Lys Glu Gln 
        35                  40                  45              


Xaa Val Gln Tyr Ile Leu Xaa Met Val Asp Asp Met Leu Gln Glu Asn 
    50                  55                  60                  


His Gln Arg Val Ser Ile Phe Phe Asp Tyr Ala Arg Cys Ser Lys Asn 
65                  70                  75                  80  


Xaa Ala Trp Pro Tyr Phe Leu Pro Met Leu Asn Arg Gln Asp Pro Phe 
                85                  90                  95      


Xaa Val His Met Ala Ala Arg Ile Ile Ala Lys Leu Ala Ala Trp Gly 
            100                 105                 110         


Lys Glu Leu Met Glu Gly Ser Asp Leu Asn Tyr Tyr Phe Asn Trp Ile 
        115                 120                 125             


Lys Xaa Gln Leu Ser Ser Gln Lys Leu Arg Gly Ser Gly Val Ala Val 
    130                 135                 140                 


Glu Xaa Gly Xaa Val Ser Ser Ser Asp Ser Ser Gln Tyr Val Gln Cys 
145                 150                 155                 160 


Val Ala Gly Cys Leu Gln Leu Met Leu Arg Val Asn Glu Tyr Arg Phe 
                165                 170                 175     


Ala Trp Val Glu Ala Asp Gly Val Asn Cys Ile Met Gly Val Leu Ser 
            180                 185                 190         


Asn Lys Cys Gly Phe Gln Leu Gln Tyr Gln Met Ile Phe Ser Ile Trp 
        195                 200                 205             


Leu Leu Ala Phe Ser Pro Gln Met Cys Glu His Leu Arg Arg Tyr Asn 
    210                 215                 220                 


Ile Ile Pro Val Leu Ser Asp Ile Leu Gln Glu Ser Val Lys Glu Lys 
225                 230                 235                 240 


Val Xaa Arg Ile Ile Leu Ala Ala Phe Arg Asn Phe Leu Glu Lys Ser 
                245                 250                 255     


Xaa Glu Arg Glu Xaa Arg Gln Glu Tyr Ala Leu Ala Met Ile Gln Cys 
            260                 265                 270         


Lys Val Leu Lys Gln Leu Glu Asn Leu Glu Gln Gln Lys Tyr Asp Asp 
        275                 280                 285             


Glu Asp Ile Ser Glu Asp Ile Lys Phe Leu Leu Glu Lys Leu Gly Glu 
    290                 295                 300                 


Ser Val Gln Asp Leu Ser Ser Phe Asp Glu Tyr Ser Ser Glu Leu Lys 
305                 310                 315                 320 


Ser Gly Arg Leu Glu Trp Ser Pro Val His Lys Ser Glu Lys Phe Trp 
                325                 330                 335     


Arg Glu Asn Ala Val Arg Leu Asn Glu Lys Asn Tyr Glu Leu Leu Lys 
            340                 345                 350         


Ile Leu Xaa Lys Leu Leu Glu Val Ser Asp Asp Pro Gln Val Leu Ala 
        355                 360                 365             


Val Ala Ala His Asp Val Gly Glu Tyr Val Arg His Tyr Pro Arg Gly 
    370                 375                 380                 


Lys Arg Val Ile Glu Gln Leu Gly Gly Lys Gln Leu Val Met Asn His 
385                 390                 395                 400 


Met His His Glu Asp Gln Gln Val Arg Tyr Asn Ala Leu Leu Ala Val 
                405                 410                 415     


Gln Lys Leu Met Val His Asn Trp Glu Tyr Leu Gly Lys Gln Leu Gln 
            420                 425                 430         


Ser Glu Gln Pro Gln Xaa Ala Ala Ala Arg Ser 
        435                 440             


<210> 3699
<211> 101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 3699
Met Xaa Lys Met Asp Ile Arg Gly Ala Val Asp Ala Ala Val Pro Xaa 
1               5                   10                  15      


Asn Ile Ile Ala Ala Lys Ala Ala Glu Val Arg Ala Asn Lys Val Asn 
            20                  25                  30          


Trp Gln Ser Tyr Leu Gln Gly Gln Met Ile Ser Ala Glu Asp Cys Glu 
        35                  40                  45              


Phe Ile Gln Arg Phe Glu Met Lys Arg Ser Pro Glu Glu Lys Gln Glu 
    50                  55                  60                  


Met Leu Gln Xaa Glu Gly Ser Gln Cys Ala Lys Xaa Phe Ile Asn Leu 
65                  70                  75                  80  


Met Xaa His Ile Cys Lys Glu Gln Xaa Val Gln Tyr Ile Leu Xaa Met 
                85                  90                  95      


Val Asp Asp Met Leu 
            100     


<210> 3700
<211> 102
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 3700
Met Xaa Lys Met Asp Ile Arg Gly Ala Val Asp Ala Ala Val Pro Xaa 
1               5                   10                  15      


Asn Ile Ile Ala Ala Lys Ala Ala Glu Val Arg Ala Asn Lys Val Asn 
            20                  25                  30          


Trp Gln Ser Tyr Leu Gln Gly Gln Met Ile Ser Ala Glu Asp Cys Glu 
        35                  40                  45              


Phe Ile Gln Arg Phe Glu Met Lys Arg Ser Pro Glu Glu Lys Gln Glu 
    50                  55                  60                  


Met Leu Gln Xaa Glu Gly Ser Gln Cys Ala Lys Xaa Phe Ile Asn Leu 
65                  70                  75                  80  


Met Xaa His Ile Cys Lys Glu Gln Xaa Val Gln Tyr Ile Leu Xaa Met 
                85                  90                  95      


Val Asp Asp Met Leu Gln 
            100         


<210> 3701
<211> 483
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<400> 3701
Met Xaa Lys Met Asp Ile Arg Gly Ala Val Asp Ala Ala Val Pro Xaa 
1               5                   10                  15      


Asn Ile Ile Ala Ala Lys Ala Ala Glu Val Arg Ala Asn Lys Val Asn 
            20                  25                  30          


Trp Gln Ser Tyr Leu Gln Gly Gln Met Ile Ser Ala Glu Asp Cys Glu 
        35                  40                  45              


Phe Ile Gln Arg Phe Glu Met Lys Arg Ser Pro Glu Glu Lys Gln Glu 
    50                  55                  60                  


Met Leu Gln Xaa Glu Gly Ser Gln Cys Ala Lys Xaa Phe Ile Asn Leu 
65                  70                  75                  80  


Met Xaa His Ile Cys Lys Glu Gln Xaa Val Gln Tyr Ile Leu Xaa Met 
                85                  90                  95      


Val Asp Asp Met Leu Gln Glu Asn His Gln Arg Val Ser Ile Phe Phe 
            100                 105                 110         


Asp Tyr Ala Arg Cys Ser Lys Asn Xaa Ala Trp Pro Tyr Phe Leu Pro 
        115                 120                 125             


Met Leu Asn Arg Gln Asp Pro Phe Xaa Val His Met Ala Ala Arg Ile 
    130                 135                 140                 


Ile Ala Lys Leu Ala Ala Trp Gly Lys Glu Leu Met Glu Gly Ser Asp 
145                 150                 155                 160 


Leu Asn Tyr Tyr Phe Asn Trp Ile Lys Xaa Gln Leu Ser Ser Gln Lys 
                165                 170                 175     


Leu Arg Gly Ser Gly Val Ala Val Glu Xaa Gly Xaa Val Ser Ser Ser 
            180                 185                 190         


Asp Ser Ser Gln Tyr Val Gln Cys Val Ala Gly Cys Leu Gln Leu Met 
        195                 200                 205             


Leu Arg Val Asn Glu Tyr Arg Phe Ala Trp Val Glu Ala Asp Gly Val 
    210                 215                 220                 


Asn Cys Ile Met Gly Val Leu Ser Asn Lys Cys Gly Phe Gln Leu Gln 
225                 230                 235                 240 


Tyr Gln Met Ile Phe Ser Ile Trp Leu Leu Ala Phe Ser Pro Gln Met 
                245                 250                 255     


Cys Glu His Leu Arg Arg Tyr Asn Ile Ile Pro Val Leu Ser Asp Ile 
            260                 265                 270         


Leu Gln Glu Ser Val Lys Glu Lys Val Xaa Arg Ile Ile Leu Ala Ala 
        275                 280                 285             


Phe Arg Asn Phe Leu Glu Lys Ser Xaa Glu Arg Glu Xaa Arg Gln Glu 
    290                 295                 300                 


Tyr Ala Leu Ala Met Ile Gln Cys Lys Val Leu Lys Gln Leu Glu Asn 
305                 310                 315                 320 


Leu Glu Gln Gln Lys Tyr Asp Asp Glu Asp Ile Ser Glu Asp Ile Lys 
                325                 330                 335     


Phe Leu Leu Glu Lys Leu Gly Glu Ser Val Gln Asp Leu Ser Ser Phe 
            340                 345                 350         


Asp Glu Tyr Ser Ser Glu Leu Lys Ser Gly Arg Leu Glu Trp Ser Pro 
        355                 360                 365             


Val His Lys Ser Glu Lys Phe Trp Arg Glu Asn Ala Val Arg Leu Asn 
    370                 375                 380                 


Glu Lys Asn Tyr Glu Leu Leu Lys Ile Leu Xaa Lys Leu Leu Glu Val 
385                 390                 395                 400 


Ser Asp Asp Pro Gln Val Leu Ala Val Ala Ala His Asp Val Gly Glu 
                405                 410                 415     


Tyr Val Arg His Tyr Pro Arg Gly Lys Arg Val Ile Glu Gln Leu Gly 
            420                 425                 430         


Gly Lys Gln Leu Val Met Asn His Met His His Glu Asp Gln Gln Val 
        435                 440                 445             


Arg Tyr Asn Ala Leu Leu Ala Val Gln Lys Leu Met Val His Asn Trp 
    450                 455                 460                 


Glu Tyr Leu Gly Lys Gln Leu Gln Ser Glu Gln Pro Gln Xaa Ala Ala 
465                 470                 475                 480 


Ala Arg Ser 
            


<210> 3702
<211> 465
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<400> 3702
Met Xaa Lys Met Asp Ile Arg Gly Ala Val Asp Ala Ala Val Pro Xaa 
1               5                   10                  15      


Asn Ile Ile Ala Ala Lys Ala Ala Glu Val Arg Ala Asn Lys Val Asn 
            20                  25                  30          


Trp Gln Ser Tyr Leu Gln Gly Gln Met Ile Ser Ala Glu Asp Cys Glu 
        35                  40                  45              


Phe Ile Gln Arg Phe Glu Met Lys Arg Ser Pro Glu Glu Lys Gln Glu 
    50                  55                  60                  


Met Leu Gln Xaa Glu Gly Ser Gln Cys Ala Lys Xaa Phe Ile Asn Leu 
65                  70                  75                  80  


Met Xaa His Ile Cys Lys Glu Gln Xaa Val Gln Tyr Ile Leu Xaa Met 
                85                  90                  95      


Val Asp Asp Met Leu Gln Glu Asn His Gln Arg Val Ser Ile Phe Phe 
            100                 105                 110         


Asp Tyr Ala Arg Cys Ser Lys Asn Xaa Ala Trp Pro Tyr Phe Leu Pro 
        115                 120                 125             


Met Leu Asn Arg Gln Asp Pro Phe Xaa Val His Met Ala Ala Arg Ile 
    130                 135                 140                 


Ile Ala Lys Leu Ala Ala Trp Gly Lys Glu Leu Met Glu Gly Ser Asp 
145                 150                 155                 160 


Leu Asn Tyr Tyr Phe Asn Trp Ile Lys Xaa Gln Leu Ser Ser Gln Ser 
                165                 170                 175     


Ser Gln Tyr Val Gln Cys Val Ala Gly Cys Leu Gln Leu Met Leu Arg 
            180                 185                 190         


Val Asn Glu Tyr Arg Phe Ala Trp Val Glu Ala Asp Gly Val Asn Cys 
        195                 200                 205             


Ile Met Gly Val Leu Ser Asn Lys Cys Gly Phe Gln Leu Gln Tyr Gln 
    210                 215                 220                 


Met Ile Phe Ser Ile Trp Leu Leu Ala Phe Ser Pro Gln Met Cys Glu 
225                 230                 235                 240 


His Leu Arg Arg Tyr Asn Ile Ile Pro Val Leu Ser Asp Ile Leu Gln 
                245                 250                 255     


Glu Ser Val Lys Glu Lys Val Xaa Arg Ile Ile Leu Ala Ala Phe Arg 
            260                 265                 270         


Asn Phe Leu Glu Lys Ser Xaa Glu Arg Glu Xaa Arg Gln Glu Tyr Ala 
        275                 280                 285             


Leu Ala Met Ile Gln Cys Lys Val Leu Lys Gln Leu Glu Asn Leu Glu 
    290                 295                 300                 


Gln Gln Lys Tyr Asp Asp Glu Asp Ile Ser Glu Asp Ile Lys Phe Leu 
305                 310                 315                 320 


Leu Glu Lys Leu Gly Glu Ser Val Gln Asp Leu Ser Ser Phe Asp Glu 
                325                 330                 335     


Tyr Ser Ser Glu Leu Lys Ser Gly Arg Leu Glu Trp Ser Pro Val His 
            340                 345                 350         


Lys Ser Glu Lys Phe Trp Arg Glu Asn Ala Val Arg Leu Asn Glu Lys 
        355                 360                 365             


Asn Tyr Glu Leu Leu Lys Ile Leu Xaa Lys Leu Leu Glu Val Ser Asp 
    370                 375                 380                 


Asp Pro Gln Val Leu Ala Val Ala Ala His Asp Val Gly Glu Tyr Val 
385                 390                 395                 400 


Arg His Tyr Pro Arg Gly Lys Arg Val Ile Glu Gln Leu Gly Gly Lys 
                405                 410                 415     


Gln Leu Val Met Asn His Met His His Glu Asp Gln Gln Val Arg Tyr 
            420                 425                 430         


Asn Ala Leu Leu Ala Val Gln Lys Leu Met Val His Asn Trp Glu Tyr 
        435                 440                 445             


Leu Gly Lys Gln Leu Gln Ser Glu Gln Pro Gln Xaa Ala Ala Ala Arg 
    450                 455                 460                 


Ser 
465 


<210> 3703
<211> 48
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<400> 3703
Met Xaa Lys Met Asp Ile Arg Gly Ala Val Asp Ala Ala Val Pro Xaa 
1               5                   10                  15      


Asn Ile Ile Ala Ala Lys Ala Ala Glu Val Arg Ala Asn Lys Val Asn 
            20                  25                  30          


Trp Gln Ser Tyr Leu Gln Gly Gln Met Ile Ser Ala Glu Asp Phe Cys 
        35                  40                  45              


<210> 3704
<211> 48
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<400> 3704
Met Xaa Lys Met Asp Ile Arg Gly Ala Val Asp Ala Ala Val Pro Xaa 
1               5                   10                  15      


Asn Ile Ile Ala Ala Lys Ala Ala Glu Val Arg Ala Asn Lys Val Asn 
            20                  25                  30          


Trp Gln Ser Tyr Leu Gln Gly Gln Met Ile Ser Ala Glu Asp Leu Cys 
        35                  40                  45              


<210> 3705
<211> 36
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<400> 3705
Met Xaa Lys Met Asp Ile Arg Gly Ala Val Asp Ala Ala Val Pro Xaa 
1               5                   10                  15      


Asn Ile Ile Ala Ala Lys Arg Cys Phe Lys Leu Lys Ala Ala Ser Val 
            20                  25                  30          


Leu Lys His Leu 
        35      


<210> 3706
<211> 60
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<400> 3706
Met Ala Val Xaa Ala Leu Ala Ala Arg Xaa Trp Leu Gly Val Trp Gly 
1               5                   10                  15      


Val Arg Xaa Met Gln Ala Arg Gly Phe Gly Ser Asp Gln Ser Glu Asn 
            20                  25                  30          


Val Asp Arg Gly Ala Gly Ser Ile Arg Glu Ala Gly Gly Ala Phe Gly 
        35                  40                  45              


Lys Arg Glu Gln Ala Glu Glu Glu Arg Tyr Phe Arg 
    50                  55                  60  


<210> 3707
<211> 75
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<400> 3707
Met Ala Val Xaa Ala Leu Ala Ala Arg Xaa Trp Leu Gly Val Trp Gly 
1               5                   10                  15      


Val Arg Xaa Met Gln Ala Arg Gly Phe Gly Ser Asp Gln Ser Glu Asn 
            20                  25                  30          


Val Asp Arg Gly Ala Gly Ser Ile Arg Glu Ala Gly Gly Ala Phe Gly 
        35                  40                  45              


Lys Arg Glu Gln Ala Glu Glu Glu Arg Tyr Phe Arg Ala Leu Gly Ala 
    50                  55                  60                  


Xaa Phe Cys Phe Phe Ala Val Glu Ala Val Val 
65                  70                  75  


<210> 3708
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<400> 3708
Met Ala Val Xaa Ala Leu Ala Ala Arg Xaa Trp Leu Gly Val Trp Gly 
1               5                   10                  15      


Val Arg Xaa Met Gln Ala Arg Gly Phe Gly Ser Asp Gln Ser Glu Asn 
            20                  25                  30          


Val Asp Arg Gly Ala Gly Ser Ile Arg Glu Ala Gly Gly Ala Phe Gly 
        35                  40                  45              


Lys Arg Glu Gln Ala Glu Glu Glu Arg Tyr Phe Arg Ala Gln Ser Arg 
    50                  55                  60                  


Glu Gln Leu Ala Ala Leu Lys Lys His His Glu Glu Glu Ile Val His 
65                  70                  75                  80  


His Lys Lys Glu Ile Glu Arg Leu Gln Lys Glu Ile Glu Arg His Lys 
                85                  90                  95      


Gln Lys Ile Lys Met Leu Lys His Asp Asp 
            100                 105     


<210> 3709
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<400> 3709
Met Ala Val Xaa Ala Leu Ala Ala Arg Xaa Trp Leu Gly Val Trp Gly 
1               5                   10                  15      


Val Arg Xaa Met Gln Ala Arg Gly Phe Gly Ser Asp Gln Ser Glu Asn 
            20                  25                  30          


Val Asp Arg Gly Ala Gly Ser Ile Arg Glu Ala Gly Gly Ala Phe Gly 
        35                  40                  45              


Lys Arg Glu Gln Ala Glu Glu Glu Arg Tyr Phe Arg His Tyr Arg Leu 
    50                  55                  60                  


Cys Phe Glu Ile Ser Leu Gly 
65                  70      


<210> 3710
<211> 39
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<400> 3710
Ala Pro Leu Asn Glu Xaa Gly Glu Val Val Asn Glu Lys Val Ser Arg 
1               5                   10                  15      


Arg Trp Gln Val Leu Gln Ile His Leu Ser Asn Val Lys Phe Val Leu 
            20                  25                  30          


Gln Arg Val Leu Pro Leu Ile 
        35                  


<210> 3711
<211> 80
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 3711
His Asn Met Val Asn Gly Met Gly Pro Met Gly Xaa Glu Gly Leu Phe 
1               5                   10                  15      


Arg Arg Ala Cys Glu Val Xaa Met Arg Leu Met Arg Asp Gln Arg Glu 
            20                  25                  30          


Pro Leu Met Ser Val Leu Lys Xaa Phe Leu His Asp Pro Leu Val Glu 
        35                  40                  45              


Trp Ser Lys Pro Val Lys Gly His Ser Lys Ala Pro Leu Asn Glu Xaa 
    50                  55                  60                  


Gly Glu Val Val Asn Glu Lys Met Ala Ser Ser Ser Asn Ser Phe Lys 
65                  70                  75                  80  


<210> 3712
<211> 2644
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1176)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1323)..(1323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1327)..(1327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1382)..(1382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1435)..(1435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1460)..(1460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1469)..(1469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1500)..(1500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1512)..(1512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1525)..(1525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1563)..(1563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1566)..(1566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1578)..(1578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1580)..(1580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1589)..(1589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1620)..(1620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1630)..(1630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1652)..(1652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1663)..(1663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1719)..(1719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1751)..(1751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1767)..(1767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1772)..(1772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1798)..(1799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1817)..(1817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1890)..(1890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1939)..(1939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1989)..(1989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2013)..(2013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2029)..(2029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2054)..(2054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2092)..(2092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2099)..(2099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2127)..(2127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2130)..(2130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2140)..(2140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2180)..(2180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2216)..(2216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2219)..(2219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2236)..(2236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2241)..(2241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2254)..(2254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2269)..(2269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2276)..(2276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2364)..(2364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2383)..(2383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2391)..(2391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2402)..(2402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2443)..(2443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2448)..(2448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2461)..(2461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2487)..(2487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2504)..(2504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2516)..(2516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2528)..(2528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2539)..(2539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2556)..(2556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2580)..(2580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2590)..(2590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2605)..(2605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2610)..(2610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2628)..(2628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2641)..(2641)
<223> Selenocysteine

<400> 3712
Met Gly Glu His Gly Leu Glu Leu Ala Ser Met Ile Pro Ala Leu Arg 
1               5                   10                  15      


Glu Leu Gly Ser Ala Xaa Pro Glu Glu Tyr Asn Xaa Val Val Gln Lys 
            20                  25                  30          


Pro Arg Gln Ile Leu Cys Gln Phe Ile Asp Arg Ile Leu Xaa Asp Val 
        35                  40                  45              


Asn Val Val Ala Val Glu Leu Val Lys Lys Xaa Asp Ser Gln Pro Xaa 
    50                  55                  60                  


Ser Val Met Leu Leu Asp Phe Ile Gln His Ile Met Lys Ser Ser Pro 
65                  70                  75                  80  


Leu Met Phe Val Asn Val Ser Gly Ser His Glu Ala Lys Gly Ser Cys 
                85                  90                  95      


Ile Glu Phe Ser Asn Trp Ile Ile Xaa Arg Leu Leu Arg Ile Ala Ala 
            100                 105                 110         


Xaa Pro Ser Cys His Leu Leu His Lys Lys Ile Cys Glu Val Ile Cys 
        115                 120                 125             


Ser Leu Leu Phe Leu Phe Lys Ser Lys Ser Pro Ala Ile Phe Gly Val 
    130                 135                 140                 


Leu Xaa Lys Glu Leu Leu Gln Leu Phe Glu Asp Leu Val Tyr Leu His 
145                 150                 155                 160 


Arg Arg Asn Val Met Gly His Ala Val Glu Trp Pro Val Val Met Ser 
                165                 170                 175     


Arg Phe Leu Ser Gln Leu Asp Glu His Met Gly Tyr Leu Gln Ser Ala 
            180                 185                 190         


Pro Leu Gln Leu Met Ser Met Gln Asn Leu Glu Phe Ile Glu Val Xaa 
        195                 200                 205             


Leu Leu Met Val Leu Xaa Arg Ile Ile Ala Ile Val Phe Phe Arg Arg 
    210                 215                 220                 


Gln Glu Leu Leu Leu Trp Gln Ile Gly Cys Val Leu Leu Glu Tyr Gly 
225                 230                 235                 240 


Ser Pro Lys Ile Lys Ser Leu Ala Ile Ser Phe Leu Xaa Glu Leu Phe 
                245                 250                 255     


Gln Leu Gly Gly Leu Pro Ala Gln Pro Ala Ser Xaa Phe Phe Ser Ser 
            260                 265                 270         


Phe Leu Glu Leu Leu Lys His Leu Val Glu Met Asp Xaa Asp Gln Leu 
        275                 280                 285             


Lys Leu Tyr Glu Glu Pro Leu Ser Lys Leu Ile Lys Xaa Leu Phe Pro 
    290                 295                 300                 


Phe Glu Ala Glu Ala Tyr Arg Asn Ile Glu Pro Val Tyr Leu Asn Met 
305                 310                 315                 320 


Leu Leu Glu Lys Leu Cys Val Met Phe Glu Asp Gly Val Leu Met Arg 
                325                 330                 335     


Leu Lys Ser Asp Leu Leu Lys Ala Ala Leu Cys His Leu Leu Gln Tyr 
            340                 345                 350         


Phe Leu Lys Phe Val Pro Ala Gly Tyr Glu Ser Ala Leu Gln Val Arg 
        355                 360                 365             


Lys Val Tyr Val Arg Asn Ile Cys Lys Ala Leu Leu Asp Val Leu Gly 
    370                 375                 380                 


Ile Glu Val Asp Ala Glu Tyr Leu Leu Gly Pro Leu Tyr Ala Ala Leu 
385                 390                 395                 400 


Lys Met Glu Ser Met Glu Ile Ile Glu Glu Ile Gln Cys Gln Xaa Gln 
                405                 410                 415     


Gln Glu Asn Leu Ser Ser Asn Ser Asp Gly Ile Ser Pro Lys Arg Arg 
            420                 425                 430         


Arg Leu Ser Ser Ser Leu Asn Pro Ser Lys Arg Ala Pro Lys Gln Xaa 
        435                 440                 445             


Glu Glu Ile Lys His Val Asp Met Asn Gln Lys Ser Ile Leu Trp Ser 
    450                 455                 460                 


Ala Leu Lys Gln Lys Ala Glu Ser Leu Gln Ile Ser Leu Glu Tyr Ser 
465                 470                 475                 480 


Gly Leu Lys Asn Pro Val Ile Glu Met Leu Glu Gly Ile Ala Val Val 
                485                 490                 495     


Leu Gln Leu Xaa Ala Leu Cys Xaa Val His Cys Ser His Gln Asn Met 
            500                 505                 510         


Asn Cys Arg Xaa Phe Lys Asp Cys Gln His Lys Ser Lys Lys Lys Pro 
        515                 520                 525             


Ser Val Val Ile Xaa Trp Met Ser Leu Asp Phe Tyr Xaa Lys Val Leu 
    530                 535                 540                 


Lys Ser Cys Arg Ser Leu Leu Glu Ser Val Gln Lys Leu Asp Leu Glu 
545                 550                 555                 560 


Ala Xaa Ile Asp Lys Val Val Lys Ile Tyr Asp Ala Leu Ile Tyr Met 
                565                 570                 575     


Gln Val Asn Ser Ser Phe Glu Asp His Ile Leu Glu Asp Leu Cys Gly 
            580                 585                 590         


Met Leu Ser Leu Pro Trp Ile Tyr Ser His Ser Asp Asp Gly Cys Leu 
        595                 600                 605             


Lys Leu Xaa Xaa Phe Ala Ala Asn Leu Leu Xaa Leu Ser Cys Arg Ile 
    610                 615                 620                 


Ser Asp Ser Tyr Ser Pro Gln Ala Gln Ser Arg Cys Val Phe Leu Leu 
625                 630                 635                 640 


Xaa Leu Phe Pro Arg Arg Ile Phe Leu Glu Trp Arg Xaa Ala Val Tyr 
                645                 650                 655     


Asn Trp Ala Leu Gln Ser Ser His Glu Val Ile Arg Ala Ser Cys Val 
            660                 665                 670         


Ser Gly Phe Phe Ile Leu Leu Gln Gln Gln Asn Ser Cys Asn Arg Val 
        675                 680                 685             


Pro Lys Ile Leu Ile Asp Lys Val Lys Asp Asp Ser Asp Ile Val Lys 
    690                 695                 700                 


Lys Glu Phe Ala Ser Ile Leu Gly Gln Leu Val Cys Xaa Leu His Gly 
705                 710                 715                 720 


Met Phe Tyr Leu Xaa Ser Ser Leu Xaa Glu Pro Phe Ser Glu His Gly 
                725                 730                 735     


His Val Asp Leu Phe Cys Arg Asn Leu Lys Ala Xaa Ser Gln His Glu 
            740                 745                 750         


Cys Ser Ser Ser Gln Leu Lys Ala Ser Val Cys Lys Pro Phe Leu Phe 
        755                 760                 765             


Leu Leu Lys Lys Lys Ile Pro Ser Pro Val Lys Leu Ala Phe Ile Asp 
    770                 775                 780                 


Asn Leu His His Leu Cys Lys His Leu Asp Phe Arg Glu Asp Glu Xaa 
785                 790                 795                 800 


Asp Val Lys Ala Val Leu Gly Xaa Leu Leu Asn Leu Met Glu Asp Pro 
                805                 810                 815     


Asp Lys Asp Val Arg Val Ala Phe Ser Gly Asn Ile Lys His Ile Leu 
            820                 825                 830         


Glu Ser Leu Asp Ser Glu Asp Gly Phe Ile Lys Glu Leu Phe Val Leu 
        835                 840                 845             


Arg Met Lys Glu Ala Tyr Xaa His Ala Gln Ile Ser Arg Asn Asn Glu 
    850                 855                 860                 


Leu Lys Asp Xaa Leu Ile Leu Xaa Xaa Gly Asp Ile Gly Arg Ala Ala 
865                 870                 875                 880 


Lys Gly Asp Leu Val Pro Phe Ala Leu Leu His Leu Leu His Cys Leu 
                885                 890                 895     


Leu Ser Lys Ser Ala Ser Val Ser Gly Ala Ala Tyr Xaa Glu Ile Arg 
            900                 905                 910         


Ala Leu Val Ala Ala Lys Ser Val Lys Leu Gln Ser Phe Phe Ser Gln 
        915                 920                 925             


Tyr Lys Lys Pro Ile Cys Gln Phe Leu Val Glu Ser Leu His Ser Ser 
    930                 935                 940                 


Gln Met Xaa Ala Leu Pro Asn Xaa Pro Cys Gln Asn Ala Asp Val Arg 
945                 950                 955                 960 


Lys Gln Asp Val Ala His Gln Arg Glu Met Ala Leu Asn Xaa Leu Ser 
                965                 970                 975     


Glu Ile Ala Asn Val Phe Asp Phe Pro Asp Leu Asn Arg Phe Leu Xaa 
            980                 985                 990         


Arg Xaa Leu Gln Val Leu Leu Pro  Asp Leu Ala Ala Lys  Ala Ser Pro 
        995                 1000                 1005             


Ala Ala  Ser Ala Leu Ile Arg  Xaa Leu Gly Lys Gln  Leu Asn Val 
    1010                 1015                 1020             


Asn Arg  Arg Glu Ile Leu Ile  Asn Asn Phe Lys Tyr  Ile Phe Ser 
    1025                 1030                 1035             


His Leu  Val Cys Ser Cys Ser  Lys Asp Glu Leu Glu  Arg Ala Leu 
    1040                 1045                 1050             


His Tyr  Leu Lys Asn Glu Xaa  Glu Ile Glu Leu Gly  Ser Leu Leu 
    1055                 1060                 1065             


Arg Gln  Asp Phe Gln Gly Leu  His Asn Glu Leu Leu  Leu Arg Ile 
    1070                 1075                 1080             


Gly Glu  His Tyr Gln Gln Val  Phe Asn Gly Leu Ser  Ile Leu Ala 
    1085                 1090                 1095             


Ser Phe  Ala Ser Ser Asp Asp  Pro Tyr Gln Gly Pro  Arg Asp Ile 
    1100                 1105                 1110             


Ile Ser  Pro Glu Leu Met Ala  Asp Tyr Leu Gln Pro  Lys Leu Leu 
    1115                 1120                 1125             


Gly Ile  Leu Ala Phe Phe Asn  Met Gln Leu Leu Ser  Ser Ser Val 
    1130                 1135                 1140             


Gly Ile  Glu Asp Lys Lys Met  Ala Leu Asn Ser Leu  Met Ser Leu 
    1145                 1150                 1155             


Met Lys  Leu Met Gly Pro Lys  His Val Ser Ser Val  Arg Val Lys 
    1160                 1165                 1170             


Met Met  Xaa Xaa Leu Arg Xaa  Gly Leu Arg Phe Lys  Asp Asp Phe 
    1175                 1180                 1185             


Pro Glu  Leu Cys Cys Arg Ala  Trp Asp Cys Phe Val  Arg Cys Leu 
    1190                 1195                 1200             


Asp His  Ala Cys Leu Gly Ser  Leu Leu Ser His Val  Ile Val Ala 
    1205                 1210                 1215             


Leu Leu  Pro Leu Ile His Ile  Gln Pro Lys Glu Xaa  Ala Ala Ile 
    1220                 1225                 1230             


Phe His  Tyr Leu Ile Ile Glu  Asn Arg Asp Ala Val  Gln Asp Phe 
    1235                 1240                 1245             


Leu His  Glu Ile Tyr Phe Leu  Pro Asp His Pro Glu  Leu Lys Lys 
    1250                 1255                 1260             


Ile Lys  Ala Val Leu Gln Glu  Tyr Arg Lys Glu Xaa  Ser Glu Ser 
    1265                 1270                 1275             


Xaa Asp  Leu Gln Xaa Xaa Leu  Gln Leu Ser Met Lys  Ala Ile Gln 
    1280                 1285                 1290             


His Glu  Asn Val Asp Val Arg  Ile His Ala Leu Xaa  Ser Leu Lys 
    1295                 1300                 1305             


Glu Xaa  Leu Tyr Lys Asn Gln  Glu Lys Leu Ile Lys  Tyr Ala Xaa 
    1310                 1315                 1320             


Asp Ser  Glu Xaa Val Glu Pro  Ile Ile Ser Gln Leu  Val Xaa Val 
    1325                 1330                 1335             


Leu Leu  Lys Gly Cys Gln Asp  Ala Asn Ser Gln Ala  Arg Leu Leu 
    1340                 1345                 1350             


Cys Gly  Glu Cys Leu Gly Glu  Leu Gly Ala Ile Asp  Pro Gly Arg 
    1355                 1360                 1365             


Leu Asp  Phe Ser Xaa Xaa Glu  Xaa Gln Gly Lys Asp  Phe Xaa Phe 
    1370                 1375                 1380             


Val Xaa  Gly Val Glu Asp Ser  Ser Phe Ala Tyr Gly  Leu Leu Met 
    1385                 1390                 1395             


Glu Leu  Xaa Arg Ala Tyr Leu  Ala Tyr Ala Asp Asn  Ser Arg Ala 
    1400                 1405                 1410             


Gln Asp  Ser Ala Ala Tyr Ala  Ile Gln Glu Leu Leu  Ser Ile Tyr 
    1415                 1420                 1425             


Asp Cys  Arg Glu Met Glu Xaa  Asn Gly Pro Gly His  Gln Leu Trp 
    1430                 1435                 1440             


Arg Arg  Phe Pro Glu His Val  Arg Glu Ile Leu Glu  Pro His Leu 
    1445                 1450                 1455             


Asn Xaa  Arg Tyr Lys Ser Ser  Gln Lys Ser Xaa Asp  Trp Ser Gly 
    1460                 1465                 1470             


Val Lys  Lys Pro Ile Tyr Leu  Ser Lys Leu Gly Ser  Asn Phe Ala 
    1475                 1480                 1485             


Glu Trp  Ser Ala Ser Trp Ala  Gly Tyr Leu Ile Xaa  Lys Val Arg 
    1490                 1495                 1500             


His Asp  Leu Ala Ser Lys Ile  Phe Xaa Cys Cys Ser  Ile Met Met 
    1505                 1510                 1515             


Lys His  Asp Phe Lys Val Xaa  Ile Tyr Leu Leu Pro  His Ile Leu 
    1520                 1525                 1530             


Val Tyr  Val Leu Leu Gly Cys  Asn Gln Glu Asp Gln  Gln Glu Val 
    1535                 1540                 1545             


Tyr Ala  Glu Ile Met Ala Val  Leu Lys His Asp Asp  Gln His Xaa 
    1550                 1555                 1560             


Ile Asn  Xaa Gln Asp Ile Ala  Ser Asp Leu Cys Gln  Leu Ser Xaa 
    1565                 1570                 1575             


Gln Xaa  Val Phe Ser Met Leu  Asp His Leu Xaa Gln  Trp Ala Arg 
    1580                 1585                 1590             


His Lys  Phe Gln Ala Leu Lys  Ala Glu Lys Cys Pro  His Ser Lys 
    1595                 1600                 1605             


Ser Asn  Arg Asn Lys Val Asp  Ser Met Val Ser Xaa  Val Asp Tyr 
    1610                 1615                 1620             


Glu Asp  Tyr Gln Ser Val Xaa  Arg Phe Leu Asp Leu  Ile Pro Gln 
    1625                 1630                 1635             


Asp Xaa  Leu Ala Val Ala Ser  Phe Arg Ser Lys Ala  Tyr Xaa Arg 
    1640                 1645                 1650             


Ala Val  Met His Phe Glu Ser  Phe Ile Xaa Glu Lys  Lys Gln Asn 
    1655                 1660                 1665             


Ile Gln  Glu His Leu Gly Phe  Leu Gln Lys Leu Tyr  Ala Ala Met 
    1670                 1675                 1680             


His Glu  Pro Asp Gly Val Ala  Gly Val Ser Ala Ile  Arg Lys Ala 
    1685                 1690                 1695             


Glu Pro  Ser Leu Lys Glu Gln  Ile Leu Glu His Glu  Ser Leu Gly 
    1700                 1705                 1710             


Leu Leu  Arg Asp Ala Xaa Ala  Cys Tyr Asp Arg Ala  Ile Gln Leu 
    1715                 1720                 1725             


Glu Pro  Asp Gln Ile Ile His  Tyr His Gly Val Val  Lys Ser Met 
    1730                 1735                 1740             


Leu Gly  Leu Gly Gln Leu Ser  Xaa Val Ile Xaa Gln  Val Asn Gly 
    1745                 1750                 1755             


Val His  Ala Asn Arg Ser Glu  Trp Xaa Asp Glu Leu  Asn Xaa Tyr 
    1760                 1765                 1770             


Arg Val  Glu Ala Ala Trp Lys  Leu Ser Gln Trp Asp  Leu Val Glu 
    1775                 1780                 1785             


Asn Tyr  Leu Ala Ala Asp Gly  Lys Ser Xaa Xaa Trp  Ser Val Arg 
    1790                 1795                 1800             


Leu Gly  Gln Leu Leu Leu Ser  Ala Lys Lys Arg Asp  Ile Xaa Ala 
    1805                 1810                 1815             


Phe Tyr  Asp Ser Leu Lys Leu  Val Arg Ala Glu Gln  Ile Val Pro 
    1820                 1825                 1830             


Leu Ser  Ala Ala Ser Phe Glu  Arg Gly Ser Tyr Gln  Arg Gly Tyr 
    1835                 1840                 1845             


Glu Tyr  Ile Val Arg Leu His  Met Leu Cys Glu Leu  Glu His Ser 
    1850                 1855                 1860             


Ile Lys  Pro Leu Phe Gln His  Ser Pro Gly Asp Ser  Ser Gln Glu 
    1865                 1870                 1875             


Asp Ser  Leu Asn Trp Val Ala  Arg Leu Glu Met Xaa  Gln Asn Ser 
    1880                 1885                 1890             


Tyr Arg  Ala Lys Glu Pro Ile  Leu Ala Leu Arg Arg  Ala Leu Leu 
    1895                 1900                 1905             


Ser Leu  Asn Lys Arg Pro Asp  Tyr Asn Glu Met Val  Gly Glu Cys 
    1910                 1915                 1920             


Trp Leu  Gln Ser Ala Arg Val  Ala Arg Lys Ala Gly  His His Gln 
    1925                 1930                 1935             


Xaa Ala  Tyr Asn Ala Leu Leu  Asn Ala Gly Glu Ser  Arg Leu Ala 
    1940                 1945                 1950             


Glu Leu  Tyr Val Glu Arg Ala  Lys Trp Leu Trp Ser  Lys Gly Asp 
    1955                 1960                 1965             


Val His  Gln Ala Leu Ile Val  Leu Gln Lys Gly Val  Glu Leu Cys 
    1970                 1975                 1980             


Phe Pro  Glu Asn Glu Xaa Pro  Pro Glu Gly Lys Asn  Met Leu Ile 
    1985                 1990                 1995             


His Gly  Arg Ala Met Leu Leu  Val Gly Arg Phe Met  Glu Glu Xaa 
    2000                 2005                 2010             


Ala Asn  Phe Glu Ser Asn Ala  Ile Met Lys Lys Tyr  Lys Asp Val 
    2015                 2020                 2025             


Xaa Ala  Cys Leu Pro Glu Trp  Glu Asp Gly His Phe  Tyr Leu Ala 
    2030                 2035                 2040             


Lys Tyr  Tyr Asp Lys Leu Met  Pro Met Val Xaa Asp  Asn Lys Met 
    2045                 2050                 2055             


Glu Lys  Gln Gly Asp Leu Ile  Arg Tyr Ile Val Leu  His Phe Gly 
    2060                 2065                 2070             


Arg Ser  Leu Gln Tyr Gly Asn  Gln Phe Ile Tyr Gln  Ser Met Pro 
    2075                 2080                 2085             


Arg Met  Leu Xaa Leu Trp Leu  Asp Tyr Gly Xaa Lys  Ala Tyr Glu 
    2090                 2095                 2100             


Trp Glu  Lys Ala Gly Arg Ser  Asp Arg Val Gln Met  Arg Asn Asp 
    2105                 2110                 2115             


Leu Gly  Lys Ile Asn Lys Val  Ile Xaa Glu His Xaa  Asn Tyr Leu 
    2120                 2125                 2130             


Ala Pro  Tyr Gln Phe Leu Xaa  Ala Phe Ser Gln Leu  Ile Ser Arg 
    2135                 2140                 2145             


Ile Cys  His Ser His Asp Glu  Val Phe Val Val Leu  Met Glu Ile 
    2150                 2155                 2160             


Ile Ala  Lys Val Phe Leu Ala  Tyr Pro Gln Gln Ala  Met Trp Met 
    2165                 2170                 2175             


Met Xaa  Ala Val Ser Lys Ser  Ser Tyr Pro Met Arg  Val Asn Arg 
    2180                 2185                 2190             


Cys Lys  Glu Ile Leu Asn Lys  Ala Ile His Met Lys  Lys Ser Leu 
    2195                 2200                 2205             


Glu Lys  Phe Val Gly Asp Ala  Xaa Arg Leu Xaa Asp  Lys Leu Leu 
    2210                 2215                 2220             


Glu Leu  Cys Asn Lys Pro Val  Asp Gly Ser Ser Ser  Xaa Leu Ser 
    2225                 2230                 2235             


Met Ser  Xaa His Phe Lys Met  Leu Lys Lys Leu Val  Glu Glu Ala 
    2240                 2245                 2250             


Xaa Phe  Ser Glu Ile Leu Ile  Pro Leu Gln Ser Val  Met Ile Pro 
    2255                 2260                 2265             


Xaa Leu  Pro Ser Ile Leu Gly  Xaa His Ala Asn His  Ala Ser His 
    2270                 2275                 2280             


Glu Pro  Phe Pro Gly His Trp  Ala Tyr Ile Ala Gly  Phe Asp Asp 
    2285                 2290                 2295             


Met Val  Glu Ile Leu Ala Ser  Leu Gln Lys Pro Lys  Lys Ile Ser 
    2300                 2305                 2310             


Leu Lys  Gly Ser Asp Gly Lys  Phe Tyr Ile Met Met  Cys Lys Pro 
    2315                 2320                 2325             


Lys Asp  Asp Leu Arg Lys Asp  Cys Arg Leu Met Glu  Phe Asn Ser 
    2330                 2335                 2340             


Leu Ile  Asn Lys Cys Leu Arg  Lys Asp Ala Glu Ser  Arg Arg Arg 
    2345                 2350                 2355             


Glu Leu  His Ile Arg Xaa Tyr  Ala Val Ile Pro Leu  Asn Asp Glu 
    2360                 2365                 2370             


Cys Gly  Ile Ile Glu Trp Val  Asn Asn Xaa Ala Gly  Leu Arg Pro 
    2375                 2380                 2385             


Ile Leu  Xaa Lys Leu Tyr Lys  Glu Lys Gly Val Tyr  Met Xaa Gly 
    2390                 2395                 2400             


Lys Glu  Leu Arg Gln Cys Met  Leu Pro Lys Ser Ala  Ala Leu Ser 
    2405                 2410                 2415             


Glu Lys  Leu Lys Val Phe Arg  Glu Phe Leu Leu Pro  Arg His Pro 
    2420                 2425                 2430             


Pro Ile  Phe His Glu Trp Phe  Leu Arg Xaa Phe Pro  Asp Pro Xaa 
    2435                 2440                 2445             


Ser Trp  Tyr Ser Ser Arg Ser  Ala Tyr Cys Arg Ser  Xaa Ala Val 
    2450                 2455                 2460             


Met Ser  Met Val Gly Tyr Ile  Leu Gly Leu Gly Asp  Arg His Gly 
    2465                 2470                 2475             


Glu Asn  Ile Leu Phe Asp Ser  Leu Xaa Gly Glu Cys  Val His Val 
    2480                 2485                 2490             


Asp Phe  Asn Cys Leu Phe Asn  Lys Gly Glu Xaa Phe  Glu Val Pro 
    2495                 2500                 2505             


Glu Ile  Val Pro Phe Arg Leu  Xaa His Asn Met Val  Asn Gly Met 
    2510                 2515                 2520             


Gly Pro  Met Gly Xaa Glu Gly  Leu Phe Arg Arg Ala  Cys Glu Val 
    2525                 2530                 2535             


Xaa Met  Arg Leu Met Arg Asp  Gln Arg Glu Pro Leu  Met Ser Val 
    2540                 2545                 2550             


Leu Lys  Xaa Phe Leu His Asp  Pro Leu Val Glu Trp  Ser Lys Pro 
    2555                 2560                 2565             


Val Lys  Gly His Ser Lys Ala  Pro Leu Asn Glu Xaa  Gly Glu Val 
    2570                 2575                 2580             


Val Asn  Glu Lys Ala Lys Xaa  His Val Leu Asp Ile  Glu Gln Arg 
    2585                 2590                 2595             


Leu Gln  Gly Val Ile Lys Xaa  Arg Asn Arg Val Xaa  Gly Leu Pro 
    2600                 2605                 2610             


Leu Ser  Ile Glu Gly His Val  His Tyr Leu Ile Gln  Glu Ala Xaa 
    2615                 2620                 2625             


Asp Glu  Asn Leu Leu Cys Gln  Met Tyr Leu Gly Trp  Xaa Pro Tyr 
    2630                 2635                 2640             


Met 
    


<210> 3713
<211> 100
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 3713
Met Gly Glu His Gly Leu Glu Leu Ala Ser Met Ile Pro Ala Leu Arg 
1               5                   10                  15      


Glu Leu Gly Ser Ala Xaa Pro Glu Glu Tyr Asn Xaa Val Val Gln Lys 
            20                  25                  30          


Pro Arg Gln Ile Leu Cys Gln Phe Ile Asp Arg Ile Leu Xaa Asp Val 
        35                  40                  45              


Asn Val Val Ala Val Glu Leu Val Lys Lys Xaa Asp Ser Gln Pro Xaa 
    50                  55                  60                  


Ser Val Met Leu Leu Asp Phe Ile Gln His Ile Met Lys Ser Ser Pro 
65                  70                  75                  80  


Leu Met Phe Val Asn Val Ser Gly Ser His Glu Ala Lys Gly Ser Cys 
                85                  90                  95      


Ile Val Phe Pro 
            100 


<210> 3714
<211> 309
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<400> 3714
Met Leu Leu Glu Lys Leu Cys Val Met Phe Glu Asp Gly Val Leu Met 
1               5                   10                  15      


Arg Leu Lys Ser Asp Leu Leu Lys Ala Ala Leu Cys His Leu Leu Gln 
            20                  25                  30          


Tyr Phe Leu Lys Phe Val Pro Ala Gly Tyr Glu Ser Ala Leu Gln Val 
        35                  40                  45              


Arg Lys Val Tyr Val Arg Asn Ile Cys Lys Ala Leu Leu Asp Val Leu 
    50                  55                  60                  


Gly Ile Glu Val Asp Ala Glu Tyr Leu Leu Gly Pro Leu Tyr Ala Ala 
65                  70                  75                  80  


Leu Lys Met Glu Ser Met Glu Ile Ile Glu Glu Ile Gln Cys Gln Xaa 
                85                  90                  95      


Gln Gln Glu Asn Leu Ser Ser Asn Ser Asp Gly Ile Ser Pro Lys Arg 
            100                 105                 110         


Arg Arg Leu Ser Ser Ser Leu Asn Pro Ser Lys Arg Ala Pro Lys Gln 
        115                 120                 125             


Xaa Glu Asp Arg Xaa Phe Lys Asp Cys Gln His Lys Ser Lys Lys Lys 
    130                 135                 140                 


Pro Ser Val Val Ile Xaa Trp Met Ser Leu Asp Phe Tyr Xaa Lys Val 
145                 150                 155                 160 


Leu Lys Ser Cys Arg Ser Leu Leu Glu Ser Val Gln Lys Leu Asp Leu 
                165                 170                 175     


Glu Ala Xaa Ile Asp Lys Val Val Lys Ile Tyr Asp Ala Leu Ile Tyr 
            180                 185                 190         


Met Gln Val Asn Ser Ser Phe Glu Asp His Ile Leu Glu Asp Leu Cys 
        195                 200                 205             


Gly Met Leu Ser Leu Pro Trp Ile Tyr Ser His Ser Asp Asp Gly Cys 
    210                 215                 220                 


Leu Lys Leu Xaa Xaa Phe Ala Ala Asn Leu Leu Xaa Leu Ser Cys Arg 
225                 230                 235                 240 


Ile Ser Asp Ser Tyr Ser Pro Gln Ala Gln Ser Arg Cys Val Phe Leu 
                245                 250                 255     


Leu Xaa Leu Phe Pro Arg Arg Ile Phe Leu Glu Trp Arg Xaa Ala Val 
            260                 265                 270         


Tyr Asn Trp Ala Leu Gln Ser Ser His Glu Val Ile Arg Ala Ser Cys 
        275                 280                 285             


Val Ser Gly Phe Phe Ile Leu Leu Gln Gln Gln Asn Ser Cys Asn Arg 
    290                 295                 300                 


Val Pro Lys Ile Leu 
305                 


<210> 3715
<211> 457
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<400> 3715
Xaa Glu Val Phe Val Val Leu Met Glu Ile Ile Ala Lys Val Phe Leu 
1               5                   10                  15      


Ala Tyr Pro Gln Gln Ala Met Trp Met Met Xaa Ala Val Ser Lys Ser 
            20                  25                  30          


Ser Tyr Pro Met Arg Val Asn Arg Cys Lys Glu Ile Leu Asn Lys Ala 
        35                  40                  45              


Ile His Met Lys Lys Ser Leu Glu Lys Phe Val Gly Asp Ala Xaa Arg 
    50                  55                  60                  


Leu Xaa Asp Lys Leu Leu Glu Leu Cys Asn Lys Pro Val Asp Gly Ser 
65                  70                  75                  80  


Ser Ser Xaa Leu Ser Met Ser Xaa His Phe Lys Met Leu Lys Lys Leu 
                85                  90                  95      


Val Glu Glu Ala Xaa Phe Ser Glu Ile Leu Ile Pro Leu Gln Ser Val 
            100                 105                 110         


Met Ile Pro Xaa Leu Pro Ser Ile Leu Gly Xaa His Ala Asn His Ala 
        115                 120                 125             


Ser His Glu Pro Phe Pro Gly His Trp Ala Tyr Ile Ala Gly Phe Asp 
    130                 135                 140                 


Asp Met Val Glu Ile Leu Ala Ser Leu Gln Lys Pro Lys Lys Ile Ser 
145                 150                 155                 160 


Leu Lys Gly Ser Asp Gly Lys Phe Tyr Ile Met Met Cys Lys Pro Lys 
                165                 170                 175     


Asp Asp Leu Arg Lys Asp Cys Arg Leu Met Glu Phe Asn Ser Leu Ile 
            180                 185                 190         


Asn Lys Cys Leu Arg Lys Asp Ala Glu Ser Arg Arg Arg Glu Leu His 
        195                 200                 205             


Ile Arg Xaa Tyr Ala Val Ile Pro Leu Asn Asp Glu Cys Gly Ile Ile 
    210                 215                 220                 


Glu Trp Val Asn Asn Xaa Ala Gly Leu Arg Pro Ile Leu Xaa Lys Leu 
225                 230                 235                 240 


Tyr Lys Glu Lys Gly Val Tyr Met Xaa Gly Lys Glu Leu Arg Gln Cys 
                245                 250                 255     


Met Leu Pro Lys Ser Ala Ala Leu Ser Glu Lys Leu Lys Val Phe Arg 
            260                 265                 270         


Glu Phe Leu Leu Pro Arg His Pro Pro Ile Phe His Glu Trp Phe Leu 
        275                 280                 285             


Arg Xaa Phe Pro Asp Pro Xaa Ser Trp Tyr Ser Ser Arg Ser Ala Tyr 
    290                 295                 300                 


Cys Arg Ser Xaa Ala Val Met Ser Met Val Gly Tyr Ile Leu Gly Leu 
305                 310                 315                 320 


Gly Asp Arg His Gly Glu Asn Ile Leu Phe Asp Ser Leu Xaa Gly Glu 
                325                 330                 335     


Cys Val His Val Asp Phe Asn Cys Leu Phe Asn Lys Gly Glu Xaa Phe 
            340                 345                 350         


Glu Val Pro Glu Ile Val Pro Phe Arg Leu Xaa His Asn Met Val Asn 
        355                 360                 365             


Gly Met Gly Pro Met Gly Xaa Glu Gly Leu Phe Arg Arg Ala Cys Glu 
    370                 375                 380                 


Val Xaa Met Arg Leu Met Arg Asp Gln Arg Glu Pro Leu Met Ser Val 
385                 390                 395                 400 


Leu Lys Xaa Phe Leu His Asp Pro Leu Val Glu Trp Ser Lys Pro Val 
                405                 410                 415     


Lys Gly His Ser Lys Ala Pro Leu Asn Glu Xaa Gly Glu Val Val Asn 
            420                 425                 430         


Glu Lys Val Ser Arg Arg Tyr Ser Leu Ile Trp Ala Val Val Leu Ile 
        435                 440                 445             


Ser Xaa Asn Glu Leu Asp Met Gln Leu 
    450                 455         


<210> 3716
<211> 764
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<400> 3716
Met Ala Gly Xaa Ser Ala Pro Gly Ser Lys Arg Arg Ser Glu Pro Pro 
1               5                   10                  15      


Ala Pro Arg Pro Gly Pro Pro Pro Gly Xaa Gly His Pro Pro Ser Lys 
            20                  25                  30          


Arg Ala Arg Gly Phe Ser Ala Ala Ala Ala Pro Asp Pro Asp Asp Pro 
        35                  40                  45              


Phe Gly Ala His Gly Asp Phe Xaa Ala Asp Asp Leu Glu Glu Leu Asp 
    50                  55                  60                  


Xaa Leu Ala Ser Gln Ala Leu Ser Gln Cys Pro Ala Ala Ala Arg Asp 
65                  70                  75                  80  


Val Ser Ser Asp His Lys Val His Arg Leu Leu Asp Gly Met Ser Lys 
                85                  90                  95      


Asn Pro Ser Gly Lys Asn Arg Glu Xaa Val Pro Ile Lys Asp Asn Phe 
            100                 105                 110         


Glu Leu Glu Val Leu Gln Ala Gln Tyr Lys Glu Leu Lys Glu Lys Met 
        115                 120                 125             


Lys Val Met Glu Glu Glu Val Leu Ile Lys Asn Gly Glu Ile Lys Ile 
    130                 135                 140                 


Leu Arg Asp Ser Leu His Gln Xaa Glu Ser Val Leu Glu Glu Gln Arg 
145                 150                 155                 160 


Arg Ser His Phe Leu Leu Glu Gln Glu Lys Xaa Gln Ala Leu Ser Asp 
                165                 170                 175     


Lys Glu Lys Glu Phe Ser Lys Lys Leu Gln Ser Leu Gln Ser Glu Leu 
            180                 185                 190         


Gln Phe Lys Asp Ala Glu Met Asn Glu Leu Arg Xaa Lys Leu Gln Xaa 
        195                 200                 205             


Ser Glu Arg Ala Asn Lys Leu Ala Ala Pro Ser Val Ser His Val Ser 
    210                 215                 220                 


Pro Arg Lys Asn Pro Ser Val Val Ile Lys Pro Glu Ala Cys Ser Pro 
225                 230                 235                 240 


Gln Phe Gly Lys Xaa Ser Phe Pro Xaa Lys Glu Ser Phe Ser Ala Asn 
                245                 250                 255     


Met Ser Leu Pro His Pro Cys Gln Xaa Glu Ser Gly Tyr Lys Pro Leu 
            260                 265                 270         


Val Gly Arg Glu Asp Ser Lys Pro His Ser Leu Arg Gly Asp Ser Ile 
        275                 280                 285             


Lys Gln Glu Glu Ala Gln Lys Ser Phe Val Asp Ser Trp Arg Gln Arg 
    290                 295                 300                 


Ser Asn Xaa Gln Gly Ser Ile Leu Ile Asn Leu Leu Leu Lys Gln Pro 
305                 310                 315                 320 


Leu Ile Pro Gly Ser Ser Leu Ser Leu Cys His Leu Leu Ser Ser Ser 
                325                 330                 335     


Ser Glu Ser Pro Ala Gly Xaa Pro Leu Gln Pro Pro Gly Phe Gly Ser 
            340                 345                 350         


Xaa Leu Ala Gly Met Ser Gly Leu Arg Xaa Xaa Gly Ser Tyr Asp Gly 
        355                 360                 365             


Ser Phe Ser Leu Ser Ala Leu Arg Glu Ala Gln Asn Leu Ala Phe Xaa 
    370                 375                 380                 


Gly Leu Asn Leu Val Ala Arg Asn Glu Cys Ser Arg Asp Gly Asp Pro 
385                 390                 395                 400 


Ala Glu Gly Gly Arg Arg Ala Phe Pro Leu Cys Gln Leu Pro Gly Ala 
                405                 410                 415     


Val His Phe Leu Pro Leu Val Gln Phe Phe Ile Gly Leu His Cys Gln 
            420                 425                 430         


Ala Leu Gln Asp Leu Ala Ala Ala Lys Arg Ser Gly Ala Pro Gly Asp 
        435                 440                 445             


Ser Pro Xaa His Ser Ser Cys Val Ser Ser Gly Val Glu Xaa Asn Pro 
    450                 455                 460                 


Glu Asp Ser Val Cys Ile Leu Glu Gly Phe Ser Val Xaa Ala Leu Ser 
465                 470                 475                 480 


Ile Leu Gln His Leu Val Cys His Ser Gly Ala Val Val Ser Leu Leu 
                485                 490                 495     


Leu Ser Gly Val Gly Ala Asp Ser Ala Ala Gly Glu Gly Asn Arg Ser 
            500                 505                 510         


Leu Val His Arg Leu Ser Asp Gly Asp Met Xaa Ser Ala Leu Arg Gly 
        515                 520                 525             


Val Ala Asp Asp Gln Gly Gln His Pro Leu Leu Lys Met Leu Leu His 
    530                 535                 540                 


Leu Leu Ala Phe Ser Ser Ala Ala Xaa Gly His Leu Gln Ala Ser Val 
545                 550                 555                 560 


Leu Xaa Gln Cys Leu Lys Val Leu Val Lys Leu Ala Glu Asn Xaa Ser 
                565                 570                 575     


Cys Asp Phe Leu Pro Arg Phe Gln Cys Val Phe Gln Val Leu Pro Lys 
            580                 585                 590         


Cys Leu Ser Pro Glu Xaa Pro Leu Pro Ser Val Leu Leu Ala Val Glu 
        595                 600                 605             


Leu Leu Ser Leu Leu Ala Asp His Asp Gln Leu Ala Pro Gln Leu Cys 
    610                 615                 620                 


Ser His Ser Glu Gly Cys Leu Leu Leu Leu Leu Tyr Met Tyr Ile Xaa 
625                 630                 635                 640 


Ser Arg Pro Asp Arg Val Ala Leu Glu Xaa Gln Trp Leu Gln Leu Glu 
                645                 650                 655     


Gln Glu Val Val Arg Ala Leu Xaa Val Met Leu His Arg Gln Trp Leu 
            660                 665                 670         


Xaa Val Arg Arg Ala Gly Gly Pro Pro Arg Xaa Asp Gln Gln Arg Arg 
        675                 680                 685             


Xaa Val Arg Cys Leu Arg Asp Xaa Val Leu Leu Leu His Gly Leu Ser 
    690                 695                 700                 


Gln Lys Asp Lys Leu Phe Met Met His Cys Val Glu Val Leu His Gln 
705                 710                 715                 720 


Phe Asp Gln Val Met Pro Gly Val Ser Met Leu Ile Arg Gly Leu Pro 
                725                 730                 735     


Asp Val Xaa Asp Cys Glu Glu Ala Ala Leu Asp Asp Leu Cys Ala Ala 
            740                 745                 750         


Glu Xaa Asp Val Glu Asp Pro Glu Val Glu Cys Gly 
        755                 760                 


<210> 3717
<211> 791
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<400> 3717
Met Ala Gly Xaa Ser Ala Pro Gly Ser Lys Arg Arg Ser Glu Pro Pro 
1               5                   10                  15      


Ala Pro Arg Pro Gly Pro Pro Pro Gly Xaa Gly His Pro Pro Ser Lys 
            20                  25                  30          


Arg Ala Arg Gly Phe Ser Ala Ala Ala Ala Pro Asp Pro Asp Asp Pro 
        35                  40                  45              


Phe Gly Ala His Gly Asp Phe Xaa Ala Asp Asp Leu Glu Glu Leu Asp 
    50                  55                  60                  


Xaa Leu Ala Ser Gln Ala Leu Ser Gln Cys Pro Ala Ala Ala Arg Asp 
65                  70                  75                  80  


Val Ser Ser Asp His Lys Val His Arg Leu Leu Asp Gly Met Ser Lys 
                85                  90                  95      


Asn Pro Ser Gly Lys Asn Arg Glu Xaa Val Pro Ile Lys Asp Asn Phe 
            100                 105                 110         


Glu Leu Glu Val Leu Gln Ala Gln Tyr Lys Glu Leu Lys Glu Lys Met 
        115                 120                 125             


Lys Val Met Glu Glu Glu Val Leu Ile Lys Asn Gly Glu Ile Lys Ile 
    130                 135                 140                 


Leu Arg Asp Ser Leu His Gln Xaa Glu Ser Val Leu Glu Glu Gln Arg 
145                 150                 155                 160 


Arg Ser His Phe Leu Leu Glu Gln Glu Lys Xaa Gln Ala Leu Ser Asp 
                165                 170                 175     


Lys Glu Lys Glu Phe Ser Lys Lys Leu Gln Ser Leu Gln Ser Glu Leu 
            180                 185                 190         


Gln Phe Lys Asp Ala Glu Met Asn Glu Leu Arg Xaa Lys Leu Gln Xaa 
        195                 200                 205             


Ser Glu Arg Ala Asn Lys Leu Ala Ala Pro Ser Val Ser His Val Ser 
    210                 215                 220                 


Pro Arg Lys Asn Pro Ser Val Val Ile Lys Pro Glu Ala Cys Ser Pro 
225                 230                 235                 240 


Gln Phe Gly Lys Xaa Ser Phe Pro Xaa Lys Glu Ser Phe Ser Ala Asn 
                245                 250                 255     


Met Ser Leu Pro His Pro Cys Gln Xaa Glu Ser Gly Tyr Lys Pro Leu 
            260                 265                 270         


Val Gly Arg Glu Asp Ser Lys Pro His Ser Leu Arg Gly Asp Ser Ile 
        275                 280                 285             


Lys Gln Glu Glu Ala Gln Lys Ser Phe Val Asp Ser Trp Arg Gln Arg 
    290                 295                 300                 


Ser Asn Xaa Gln Gly Ser Ile Leu Ile Asn Leu Leu Leu Lys Gln Pro 
305                 310                 315                 320 


Leu Ile Pro Gly Ser Ser Leu Ser Leu Cys His Leu Leu Ser Ser Ser 
                325                 330                 335     


Ser Glu Ser Pro Ala Gly Xaa Pro Leu Gln Pro Pro Gly Phe Gly Ser 
            340                 345                 350         


Xaa Leu Ala Gly Met Ser Gly Leu Arg Xaa Xaa Gly Ser Tyr Asp Gly 
        355                 360                 365             


Ser Phe Ser Leu Ser Ala Leu Arg Glu Ala Gln Asn Leu Ala Phe Xaa 
    370                 375                 380                 


Gly Leu Asn Leu Val Ala Arg Asn Glu Cys Ser Arg Asp Gly Asp Pro 
385                 390                 395                 400 


Ala Glu Gly Gly Arg Arg Ala Phe Pro Leu Cys Gln Leu Pro Gly Ala 
                405                 410                 415     


Val His Phe Leu Pro Leu Val Gln Phe Phe Ile Gly Leu His Cys Gln 
            420                 425                 430         


Ala Leu Gln Asp Leu Ala Ala Ala Lys Arg Ser Gly Ala Pro Gly Asp 
        435                 440                 445             


Ser Pro Xaa His Ser Ser Cys Val Ser Ser Gly Val Glu Xaa Asn Pro 
    450                 455                 460                 


Glu Asp Ser Val Cys Ile Leu Glu Gly Phe Ser Val Xaa Ala Leu Ser 
465                 470                 475                 480 


Ile Leu Gln His Leu Val Cys His Ser Gly Ala Val Val Ser Leu Leu 
                485                 490                 495     


Leu Ser Gly Val Gly Ala Asp Ser Ala Ala Gly Glu Gly Asn Arg Ser 
            500                 505                 510         


Leu Val His Arg Leu Ser Asp Gly Asp Met Xaa Ser Ala Leu Arg Gly 
        515                 520                 525             


Val Ala Asp Asp Gln Gly Gln His Pro Leu Leu Lys Met Leu Leu His 
    530                 535                 540                 


Leu Leu Ala Phe Ser Ser Ala Ala Xaa Gly His Leu Gln Ala Ser Val 
545                 550                 555                 560 


Leu Xaa Gln Cys Leu Lys Val Leu Val Lys Leu Ala Glu Asn Xaa Ser 
                565                 570                 575     


Cys Asp Phe Leu Pro Arg Phe Gln Cys Val Phe Gln Val Leu Pro Lys 
            580                 585                 590         


Cys Leu Ser Pro Glu Xaa Pro Leu Pro Ser Val Leu Leu Ala Val Glu 
        595                 600                 605             


Leu Leu Ser Leu Leu Ala Asp His Asp Gln Leu Ala Pro Gln Leu Cys 
    610                 615                 620                 


Ser His Ser Glu Gly Cys Leu Leu Leu Leu Leu Tyr Met Tyr Ile Xaa 
625                 630                 635                 640 


Ser Arg Pro Asp Arg Val Ala Leu Glu Xaa Gln Trp Leu Gln Leu Glu 
                645                 650                 655     


Gln Glu Val Val Trp Leu Leu Ala Lys Leu Gly Val Gln Ser Pro Leu 
            660                 665                 670         


Pro Pro Val Xaa Gly Ser Asn Cys Gln Cys Asn Val Glu Val Val Arg 
        675                 680                 685             


Ala Leu Xaa Val Met Leu His Arg Gln Trp Leu Xaa Val Arg Arg Ala 
    690                 695                 700                 


Gly Gly Pro Pro Arg Xaa Asp Gln Gln Arg Arg Xaa Val Arg Cys Leu 
705                 710                 715                 720 


Arg Asp Xaa Val Leu Leu Leu His Gly Leu Ser Gln Lys Asp Lys Leu 
                725                 730                 735     


Phe Met Met His Cys Val Glu Val Leu His Gln Phe Asp Gln Val Met 
            740                 745                 750         


Pro Gly Val Ser Met Leu Ile Arg Gly Leu Pro Asp Val Xaa Asp Cys 
        755                 760                 765             


Glu Glu Ala Ala Leu Asp Asp Leu Cys Ala Ala Glu Xaa Asp Val Glu 
    770                 775                 780                 


Asp Pro Glu Val Glu Cys Gly 
785                 790     


<210> 3718
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 3718
Met Ser Lys Asn Pro Ser Gly Lys Asn Arg Glu Xaa Val Pro Ile Lys 
1               5                   10                  15      


Asp Asn Phe Glu Leu Glu Val Leu Gln Ala Gln Tyr Lys Glu Leu Lys 
            20                  25                  30          


Glu Lys Met Lys Val Met Glu Glu Glu Val Leu Ile Lys Asn Gly Glu 
        35                  40                  45              


Ile Lys Ile Leu Arg Asp Ser Leu His Gln Xaa Glu Ser Val Leu Glu 
    50                  55                  60                  


Glu Gln Arg Arg Ser His Phe Leu Leu Glu Gln Glu Lys Xaa Gln Ala 
65                  70                  75                  80  


Leu Ser Asp Lys Glu Lys Glu Phe Ser Lys Lys Leu Gln Ser Leu Gln 
                85                  90                  95      


Ser Glu Leu Gln Phe Lys Asp Ala Glu Met Asn Glu Leu Arg Xaa Lys 
            100                 105                 110         


Leu Gln Xaa Ser Glu Arg Ala Asn Lys Leu Ala Ala Pro Ser Val Ser 
        115                 120                 125             


His Val Arg 
    130     


<210> 3719
<211> 196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<400> 3719
Met Ser Lys Asn Pro Ser Gly Lys Asn Arg Glu Xaa Val Pro Ile Lys 
1               5                   10                  15      


Asp Asn Phe Glu Leu Glu Val Leu Gln Ala Gln Tyr Lys Glu Leu Lys 
            20                  25                  30          


Glu Lys Met Lys Val Met Glu Glu Glu Val Leu Ile Lys Asn Gly Glu 
        35                  40                  45              


Ile Lys Ile Leu Arg Asp Ser Leu His Gln Xaa Glu Ser Val Leu Glu 
    50                  55                  60                  


Glu Gln Arg Arg Ser His Phe Leu Leu Glu Gln Glu Lys Xaa Gln Ala 
65                  70                  75                  80  


Leu Ser Asp Lys Glu Lys Glu Phe Ser Lys Lys Leu Gln Ser Leu Gln 
                85                  90                  95      


Ser Glu Leu Gln Phe Lys Asp Ala Glu Met Asn Glu Leu Arg Xaa Lys 
            100                 105                 110         


Leu Gln Xaa Ser Glu Arg Ala Asn Lys Leu Ala Ala Pro Ser Val Ser 
        115                 120                 125             


His Val Ser Pro Arg Lys Asn Pro Ser Val Val Ile Lys Pro Glu Ala 
    130                 135                 140                 


Cys Ser Pro Gln Phe Gly Lys Xaa Ser Phe Pro Xaa Lys Glu Ser Phe 
145                 150                 155                 160 


Ser Ala Asn Met Ser Leu Pro His Pro Cys Gln Xaa Glu Ser Gly Tyr 
                165                 170                 175     


Lys Pro Leu Val Gly Arg Glu Asp Ser Lys Pro His Ser Leu Arg Gly 
            180                 185                 190         


Asp Ser Ile Lys 
        195     


<210> 3720
<211> 698
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<400> 3720
Met Ser Lys Asn Pro Ser Gly Lys Asn Arg Glu Xaa Val Pro Ile Lys 
1               5                   10                  15      


Asp Asn Phe Glu Leu Glu Val Leu Gln Ala Gln Tyr Lys Glu Leu Lys 
            20                  25                  30          


Glu Lys Met Lys Val Met Glu Glu Glu Val Leu Ile Lys Asn Gly Glu 
        35                  40                  45              


Ile Lys Ile Leu Arg Asp Ser Leu His Gln Xaa Glu Ser Val Leu Glu 
    50                  55                  60                  


Glu Gln Arg Arg Ser His Phe Leu Leu Glu Gln Glu Lys Xaa Gln Ala 
65                  70                  75                  80  


Leu Ser Asp Lys Glu Lys Glu Phe Ser Lys Lys Leu Gln Ser Leu Gln 
                85                  90                  95      


Ser Glu Leu Gln Phe Lys Asp Ala Glu Met Asn Glu Leu Arg Xaa Lys 
            100                 105                 110         


Leu Gln Xaa Ser Glu Arg Ala Asn Lys Leu Ala Ala Pro Ser Val Ser 
        115                 120                 125             


His Val Ser Pro Arg Lys Asn Pro Ser Val Val Ile Lys Pro Glu Ala 
    130                 135                 140                 


Cys Ser Pro Gln Phe Gly Lys Xaa Ser Phe Pro Xaa Lys Glu Ser Phe 
145                 150                 155                 160 


Ser Ala Asn Met Ser Leu Pro His Pro Cys Gln Xaa Glu Ser Gly Tyr 
                165                 170                 175     


Lys Pro Leu Val Gly Arg Glu Asp Ser Lys Pro His Ser Leu Arg Gly 
            180                 185                 190         


Asp Ser Ile Lys Gln Glu Glu Ala Gln Lys Ser Phe Val Asp Ser Trp 
        195                 200                 205             


Arg Gln Arg Ser Asn Xaa Gln Gly Ser Ile Leu Ile Asn Leu Leu Leu 
    210                 215                 220                 


Lys Gln Pro Leu Ile Pro Gly Ser Ser Leu Ser Leu Cys His Leu Leu 
225                 230                 235                 240 


Ser Ser Ser Ser Glu Ser Pro Ala Gly Xaa Pro Leu Gln Pro Pro Gly 
                245                 250                 255     


Phe Gly Ser Xaa Leu Ala Gly Met Ser Gly Leu Arg Xaa Xaa Gly Ser 
            260                 265                 270         


Tyr Asp Gly Ser Phe Ser Leu Ser Ala Leu Arg Glu Ala Gln Asn Leu 
        275                 280                 285             


Ala Phe Xaa Gly Leu Asn Leu Val Ala Arg Asn Glu Cys Ser Arg Asp 
    290                 295                 300                 


Gly Asp Pro Ala Glu Gly Gly Arg Arg Ala Phe Pro Leu Cys Gln Leu 
305                 310                 315                 320 


Pro Gly Ala Val His Phe Leu Pro Leu Val Gln Phe Phe Ile Gly Leu 
                325                 330                 335     


His Cys Gln Ala Leu Gln Asp Leu Ala Ala Ala Lys Arg Ser Gly Ala 
            340                 345                 350         


Pro Gly Asp Ser Pro Xaa His Ser Ser Cys Val Ser Ser Gly Val Glu 
        355                 360                 365             


Xaa Asn Pro Glu Asp Ser Val Cys Ile Leu Glu Gly Phe Ser Val Xaa 
    370                 375                 380                 


Ala Leu Ser Ile Leu Gln His Leu Val Cys His Ser Gly Ala Val Val 
385                 390                 395                 400 


Ser Leu Leu Leu Ser Gly Val Gly Ala Asp Ser Ala Ala Gly Glu Gly 
                405                 410                 415     


Asn Arg Ser Leu Val His Arg Leu Ser Asp Gly Asp Met Xaa Ser Ala 
            420                 425                 430         


Leu Arg Gly Val Ala Asp Asp Gln Gly Gln His Pro Leu Leu Lys Met 
        435                 440                 445             


Leu Leu His Leu Leu Ala Phe Ser Ser Ala Ala Xaa Gly His Leu Gln 
    450                 455                 460                 


Ala Ser Val Leu Xaa Gln Cys Leu Lys Val Leu Val Lys Leu Ala Glu 
465                 470                 475                 480 


Asn Xaa Ser Cys Asp Phe Leu Pro Arg Phe Gln Cys Val Phe Gln Val 
                485                 490                 495     


Leu Pro Lys Cys Leu Ser Pro Glu Xaa Pro Leu Pro Ser Val Leu Leu 
            500                 505                 510         


Ala Val Glu Leu Leu Ser Leu Leu Ala Asp His Asp Gln Leu Ala Pro 
        515                 520                 525             


Gln Leu Cys Ser His Ser Glu Gly Cys Leu Leu Leu Leu Leu Tyr Met 
    530                 535                 540                 


Tyr Ile Xaa Ser Arg Pro Asp Arg Val Ala Leu Glu Xaa Gln Trp Leu 
545                 550                 555                 560 


Gln Leu Glu Gln Glu Val Val Trp Leu Leu Ala Lys Leu Gly Val Gln 
                565                 570                 575     


Ser Pro Leu Pro Pro Val Xaa Gly Ser Asn Cys Gln Cys Asn Val Glu 
            580                 585                 590         


Val Val Arg Ala Leu Xaa Val Met Leu His Arg Gln Trp Leu Xaa Val 
        595                 600                 605             


Arg Arg Ala Gly Gly Pro Pro Arg Xaa Asp Gln Gln Arg Arg Xaa Val 
    610                 615                 620                 


Arg Cys Leu Arg Asp Xaa Val Leu Leu Leu His Gly Leu Ser Gln Lys 
625                 630                 635                 640 


Asp Lys Leu Phe Met Met His Cys Val Glu Val Leu His Gln Phe Asp 
                645                 650                 655     


Gln Val Met Pro Gly Val Ser Met Leu Ile Arg Gly Leu Pro Asp Val 
            660                 665                 670         


Xaa Asp Cys Glu Glu Ala Ala Leu Asp Asp Leu Cys Ala Ala Glu Xaa 
        675                 680                 685             


Asp Val Glu Asp Pro Glu Val Glu Cys Gly 
    690                 695             


<210> 3721
<211> 398
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<400> 3721
Met Glu Xaa Gly Gly Arg Ala Arg Xaa Gly Xaa Pro Gln Pro Ala Ala 
1               5                   10                  15      


Pro Gly Val Trp Arg Ala Arg Pro Ala Gly Gly Gly Gly Gly Gly Ala 
            20                  25                  30          


Ser Ser Trp Leu Leu Asp Gly Asn Ser Trp Leu Leu Cys Tyr Gly Phe 
        35                  40                  45              


Leu Tyr Leu Ala Leu Tyr Ala Gln Val Ser Gln Ser Lys Pro Cys Glu 
    50                  55                  60                  


Arg Xaa Gly Ser Cys Phe Ser Gly Arg Cys Val Asn Ser Xaa Cys Leu 
65                  70                  75                  80  


Cys Asp Pro Gly Trp Val Gly Asp Gln Cys Gln His Cys Gln Gly Arg 
                85                  90                  95      


Phe Lys Leu Xaa Glu Pro Ser Gly Tyr Leu Xaa Asp Gly Pro Ile Asn 
            100                 105                 110         


Tyr Lys Tyr Lys Xaa Lys Cys Xaa Trp Leu Ile Glu Gly Tyr Pro Asn 
        115                 120                 125             


Ala Val Leu Arg Leu Arg Phe Asn His Phe Ala Xaa Glu Cys Ser Trp 
    130                 135                 140                 


Asp His Met Tyr Val Tyr Asp Gly Asp Ser Ile Tyr Ala Pro Leu Ile 
145                 150                 155                 160 


Ala Val Leu Ser Gly Leu Ile Val Pro Glu Ile Arg Gly Asn Glu Xaa 
                165                 170                 175     


Val Pro Glu Val Val Xaa Xaa Ser Gly Tyr Ala Leu Leu His Phe Phe 
            180                 185                 190         


Ser Asp Ala Ala Tyr Asn Leu Xaa Gly Phe Asn Ile Phe Tyr Ser Ile 
        195                 200                 205             


Asn Ser Cys Pro Asn Asn Cys Ser Gly His Gly Lys Cys Xaa Xaa Ser 
    210                 215                 220                 


Val Ser Val Pro Ser Gln Val Tyr Cys Glu Cys Asp Lys Tyr Trp Lys 
225                 230                 235                 240 


Gly Glu Ala Cys Asp Ile Pro Tyr Cys Lys Ala Asn Cys Gly Ser Pro 
                245                 250                 255     


Asp His Gly Tyr Cys Asp Leu Xaa Gly Glu Lys Leu Cys Val Cys Asn 
            260                 265                 270         


Asp Ser Trp Gln Gly Pro Asp Cys Ser Leu Asn Val Pro Ser Xaa Glu 
        275                 280                 285             


Ser Tyr Trp Ile Leu Pro Asn Val Lys Pro Phe Ser Pro Ser Val Gly 
    290                 295                 300                 


Arg Ala Ser His Lys Ala Val Leu His Gly Lys Phe Met Trp Val Ile 
305                 310                 315                 320 


Gly Gly Tyr Xaa Phe Asn Tyr Ser Ser Phe Gln Met Val Leu Lys Lys 
                325                 330                 335     


Xaa Ser Leu Cys Met Glu Ala Glu Leu Lys Gln Met Met Ala Met Ser 
            340                 345                 350         


Gln Met Asn Tyr Gly Phe Leu Xaa Tyr Ile Val Ser His Gly Val Gln 
        355                 360                 365             


Lys Leu Leu Leu Phe Leu Asp Met Val Ser Ser Met Leu Trp Arg Asp 
    370                 375                 380                 


Ile Gln His Ile Leu Trp Ser Trp Ile Val Glu Met Leu Ser 
385                 390                 395             


<210> 3722
<211> 467
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<400> 3722
Met Glu Xaa Gly Gly Arg Ala Arg Xaa Gly Xaa Pro Gln Pro Ala Ala 
1               5                   10                  15      


Pro Gly Val Trp Arg Ala Arg Pro Ala Gly Gly Gly Gly Gly Gly Ala 
            20                  25                  30          


Ser Ser Trp Leu Leu Asp Gly Asn Ser Trp Leu Leu Cys Tyr Gly Phe 
        35                  40                  45              


Leu Tyr Leu Ala Leu Tyr Ala Gln Val Ser Gln Ser Lys Pro Cys Glu 
    50                  55                  60                  


Arg Xaa Gly Ser Cys Phe Ser Gly Arg Cys Val Asn Ser Xaa Cys Leu 
65                  70                  75                  80  


Cys Asp Pro Gly Trp Val Gly Asp Gln Cys Gln His Cys Gln Gly Arg 
                85                  90                  95      


Phe Lys Leu Xaa Glu Pro Ser Gly Tyr Leu Xaa Asp Gly Pro Ile Asn 
            100                 105                 110         


Tyr Lys Tyr Lys Xaa Lys Cys Xaa Trp Leu Ile Glu Gly Tyr Pro Asn 
        115                 120                 125             


Ala Val Leu Arg Leu Arg Phe Asn His Phe Ala Xaa Glu Cys Ser Trp 
    130                 135                 140                 


Asp His Met Tyr Val Tyr Asp Gly Asp Ser Ile Tyr Ala Pro Leu Ile 
145                 150                 155                 160 


Ala Val Leu Ser Gly Leu Ile Val Pro Glu Ile Arg Gly Asn Glu Xaa 
                165                 170                 175     


Val Pro Glu Val Val Xaa Xaa Ser Gly Tyr Ala Leu Leu His Phe Phe 
            180                 185                 190         


Ser Asp Ala Ala Tyr Asn Leu Xaa Gly Phe Asn Ile Phe Tyr Ser Ile 
        195                 200                 205             


Asn Ser Cys Pro Asn Asn Cys Ser Gly His Gly Lys Cys Xaa Xaa Ser 
    210                 215                 220                 


Val Ser Val Pro Ser Gln Val Tyr Cys Glu Cys Asp Lys Tyr Trp Lys 
225                 230                 235                 240 


Gly Glu Ala Cys Asp Ile Pro Tyr Cys Lys Ala Asn Cys Gly Ser Pro 
                245                 250                 255     


Asp His Gly Tyr Cys Asp Leu Xaa Gly Glu Lys Leu Cys Val Cys Asn 
            260                 265                 270         


Asp Ser Trp Gln Gly Pro Asp Cys Ser Leu Asn Val Pro Ser Xaa Glu 
        275                 280                 285             


Ser Tyr Trp Ile Leu Pro Asn Val Lys Pro Phe Ser Pro Ser Val Gly 
    290                 295                 300                 


Arg Ala Ser His Lys Ala Val Leu His Gly Lys Phe Met Trp Val Ile 
305                 310                 315                 320 


Gly Gly Tyr Xaa Phe Asn Tyr Ser Ser Phe Gln Met Val Leu Asn Tyr 
                325                 330                 335     


Asn Leu Glu Ser Ser Ile Trp Asn Val Gly Xaa Pro Ser Arg Gly Pro 
            340                 345                 350         


Leu Gln Arg Tyr Gly His Ser Leu Ala Leu Tyr Gln Glu Asn Ile Phe 
        355                 360                 365             


Met Tyr Gly Gly Arg Ile Glu Xaa Asn Asp Gly Asn Val Xaa Asp Glu 
    370                 375                 380                 


Leu Trp Val Phe Asn Ile His Ser Gln Ser Trp Ser Xaa Lys Xaa Pro 
385                 390                 395                 400 


Xaa Val Leu Gly His Gly Gln Gln Tyr Ala Val Glu Gly His Ser Ala 
                405                 410                 415     


His Ile Met Glu Leu Asp Ser Arg Asp Val Val Met Ile Ile Ile Phe 
            420                 425                 430         


Gly Tyr Ser Ala Ile Tyr Gly Tyr Xaa Ser Ser Ile Gln Glu Tyr His 
        435                 440                 445             


Ile Cys Glu Leu Leu Lys Asn Cys Asn Phe Phe Ile Asp Trp Glu Cys 
    450                 455                 460                 


Phe Ser Leu 
465         


<210> 3723
<211> 1379
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1058)..(1058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1105)..(1105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1117)..(1117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1226)..(1226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1293)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1321)..(1321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1377)..(1377)
<223> Selenocysteine

<400> 3723
Met Glu Xaa Gly Gly Arg Ala Arg Xaa Gly Xaa Pro Gln Pro Ala Ala 
1               5                   10                  15      


Pro Gly Val Trp Arg Ala Arg Pro Ala Gly Gly Gly Gly Gly Gly Ala 
            20                  25                  30          


Ser Ser Trp Leu Leu Asp Gly Asn Ser Trp Leu Leu Cys Tyr Gly Phe 
        35                  40                  45              


Leu Tyr Leu Ala Leu Tyr Ala Gln Val Ser Gln Ser Lys Pro Cys Glu 
    50                  55                  60                  


Arg Xaa Gly Ser Cys Phe Ser Gly Arg Cys Val Asn Ser Xaa Cys Leu 
65                  70                  75                  80  


Cys Asp Pro Gly Trp Val Gly Asp Gln Cys Gln His Cys Gln Gly Arg 
                85                  90                  95      


Phe Lys Leu Xaa Glu Pro Ser Gly Tyr Leu Xaa Asp Gly Pro Ile Asn 
            100                 105                 110         


Tyr Lys Tyr Lys Xaa Lys Cys Xaa Trp Leu Ile Glu Gly Tyr Pro Asn 
        115                 120                 125             


Ala Val Leu Arg Leu Arg Phe Asn His Phe Ala Xaa Glu Cys Ser Trp 
    130                 135                 140                 


Asp His Met Tyr Val Tyr Asp Gly Asp Ser Ile Tyr Ala Pro Leu Ile 
145                 150                 155                 160 


Ala Val Leu Ser Gly Leu Ile Val Pro Glu Ile Arg Gly Asn Glu Xaa 
                165                 170                 175     


Val Pro Glu Val Val Xaa Xaa Ser Gly Tyr Ala Leu Leu His Phe Phe 
            180                 185                 190         


Ser Asp Ala Ala Tyr Asn Leu Xaa Gly Phe Asn Ile Phe Tyr Ser Ile 
        195                 200                 205             


Asn Ser Cys Pro Asn Asn Cys Ser Gly His Gly Lys Cys Xaa Xaa Ser 
    210                 215                 220                 


Val Ser Val Pro Ser Gln Val Tyr Cys Glu Cys Asp Lys Tyr Trp Lys 
225                 230                 235                 240 


Gly Glu Ala Cys Asp Ile Pro Tyr Cys Lys Ala Asn Cys Gly Ser Pro 
                245                 250                 255     


Asp His Gly Tyr Cys Asp Leu Xaa Gly Glu Lys Leu Cys Val Cys Asn 
            260                 265                 270         


Asp Ser Trp Gln Gly Pro Asp Cys Ser Leu Asn Val Pro Ser Xaa Glu 
        275                 280                 285             


Ser Tyr Trp Ile Leu Pro Asn Val Lys Pro Phe Ser Pro Ser Val Gly 
    290                 295                 300                 


Arg Ala Ser His Lys Ala Val Leu His Gly Lys Phe Met Trp Val Ile 
305                 310                 315                 320 


Gly Gly Tyr Xaa Phe Asn Tyr Ser Ser Phe Gln Met Val Leu Asn Tyr 
                325                 330                 335     


Asn Leu Glu Ser Ser Ile Trp Asn Val Gly Xaa Pro Ser Arg Gly Pro 
            340                 345                 350         


Leu Gln Arg Tyr Gly His Ser Leu Ala Leu Tyr Gln Glu Asn Ile Phe 
        355                 360                 365             


Met Tyr Gly Gly Arg Ile Glu Xaa Asn Asp Gly Asn Val Xaa Asp Glu 
    370                 375                 380                 


Leu Trp Val Phe Asn Ile His Ser Gln Ser Trp Ser Xaa Lys Xaa Pro 
385                 390                 395                 400 


Xaa Val Leu Gly His Gly Gln Gln Tyr Ala Val Glu Gly His Ser Ala 
                405                 410                 415     


His Ile Met Glu Leu Asp Ser Arg Asp Val Val Met Ile Ile Ile Phe 
            420                 425                 430         


Gly Tyr Ser Ala Ile Tyr Gly Tyr Xaa Ser Ser Ile Gln Glu Tyr His 
        435                 440                 445             


Ile Ser Ser Asn Xaa Trp Leu Val Pro Glu Xaa Lys Gly Ala Ile Val 
    450                 455                 460                 


Gln Gly Gly Tyr Gly His Xaa Ser Val Tyr Asp Glu Ile Xaa Lys Ser 
465                 470                 475                 480 


Ile Tyr Val His Gly Gly Tyr Lys Ala Leu Pro Gly Asn Lys Tyr Gly 
                485                 490                 495     


Leu Val Asp Asp Leu Tyr Lys Tyr Glu Val Asn Xaa Lys Xaa Trp Xaa 
            500                 505                 510         


Ile Leu Lys Glu Ser Gly Phe Ala Arg Tyr Leu His Ser Ala Val Leu 
        515                 520                 525             


Ile Asn Gly Ala Met Leu Ile Phe Gly Gly Asn Xaa His Asn Asp Xaa 
    530                 535                 540                 


Ser Leu Ser Asn Gly Ala Lys Cys Phe Ser Ala Asp Phe Leu Ala Tyr 
545                 550                 555                 560 


Asp Ile Ala Cys Asp Glu Trp Lys Ile Leu Pro Lys Pro Asn Leu His 
                565                 570                 575     


Arg Asp Val Asn Arg Phe Gly His Ser Ala Val Val Ile Asn Gly Ser 
            580                 585                 590         


Met Tyr Ile Phe Gly Gly Phe Ser Ser Val Leu Leu Asn Asp Ile Leu 
        595                 600                 605             


Val Tyr Lys Pro Pro Asn Cys Lys Ala Phe Arg Asp Glu Glu Leu Cys 
    610                 615                 620                 


Lys Asn Ala Gly Pro Gly Ile Lys Cys Val Trp Asn Lys Asn His Cys 
625                 630                 635                 640 


Glu Ser Trp Glu Ser Gly Asn Xaa Asn Asn Ile Leu Arg Ala Lys Cys 
                645                 650                 655     


Pro Pro Lys Xaa Ala Ala Ser Asp Asp Arg Cys Tyr Arg Tyr Ala Asp 
            660                 665                 670         


Cys Ala Ser Cys Xaa Ala Asn Xaa Asn Gly Cys Gln Trp Cys Asp Asp 
        675                 680                 685             


Lys Lys Cys Ile Ser Ala Asn Ser Asn Cys Ser Met Ser Val Lys Asn 
    690                 695                 700                 


Tyr Xaa Lys Cys His Val Arg Asn Glu Gln Ile Cys Asn Lys Leu Xaa 
705                 710                 715                 720 


Ser Cys Lys Ser Cys Ser Leu Asn Leu Asn Cys Gln Trp Asp Gln Arg 
                725                 730                 735     


Gln Gln Glu Cys Gln Ala Leu Pro Ala His Leu Cys Gly Glu Gly Trp 
            740                 745                 750         


Ser His Ile Gly Asp Ala Cys Leu Arg Val Asn Ser Ser Arg Glu Asn 
        755                 760                 765             


Tyr Asp Asn Ala Lys Leu Tyr Cys Tyr Asn Leu Ser Gly Asn Leu Ala 
    770                 775                 780                 


Ser Leu Xaa Xaa Ser Lys Glu Val Glu Phe Val Leu Asp Glu Ile Gln 
785                 790                 795                 800 


Lys Tyr Xaa Gln Gln Lys Val Ser Pro Trp Val Gly Leu Arg Lys Ile 
                805                 810                 815     


Asn Ile Ser Tyr Trp Gly Trp Glu Asp Met Ser Pro Phe Xaa Asn Xaa 
            820                 825                 830         


Xaa Leu Gln Trp Leu Pro Gly Glu Pro Asn Asp Ser Gly Phe Cys Ala 
        835                 840                 845             


Tyr Leu Glu Arg Ala Ala Val Ala Gly Leu Lys Ala Asn Pro Cys Xaa 
    850                 855                 860                 


Ser Met Ala Asn Gly Leu Val Cys Glu Lys Pro Val Val Ser Pro Asn 
865                 870                 875                 880 


Gln Asn Ala Arg Pro Cys Lys Lys Pro Cys Ser Leu Arg Xaa Ser Cys 
                885                 890                 895     


Ser Asn Cys Xaa Ser Asn Gly Met Glu Cys Met Trp Cys Ser Ser Xaa 
            900                 905                 910         


Lys Arg Cys Val Asp Ser Asn Ala Tyr Ile Ile Ser Phe Pro Tyr Gly 
        915                 920                 925             


Gln Cys Leu Glu Trp Gln Xaa Ala Xaa Cys Ser Pro Gln Asn Cys Ser 
    930                 935                 940                 


Gly Leu Arg Xaa Cys Gly Gln Cys Leu Glu Gln Pro Gly Cys Gly Trp 
945                 950                 955                 960 


Cys Asn Asp Pro Ser Asn Xaa Gly Arg Gly His Cys Ile Glu Gly Ser 
                965                 970                 975     


Ser Arg Gly Pro Met Lys Leu Ile Gly Met His His Ser Glu Met Val 
            980                 985                 990         


Leu Asp Xaa Asn Leu Cys Pro Lys  Glu Lys Asn Tyr Glu  Trp Ser Phe 
        995                 1000                 1005             


Ile Gln  Cys Pro Ala Cys Gln  Cys Asn Gly His Ser  Xaa Cys Ile 
    1010                 1015                 1020             


Asn Asn  Asn Val Cys Glu Gln  Cys Lys Asn Leu Xaa  Xaa Gly Lys 
    1025                 1030                 1035             


Gln Cys  Gln Asp Cys Met Pro  Gly Tyr Tyr Gly Asp  Pro Xaa Asn 
    1040                 1045                 1050             


Gly Gly  Gln Cys Xaa Ala Cys  Xaa Cys Ser Gly His  Ala Asn Ile 
    1055                 1060                 1065             


Cys His  Leu His Xaa Gly Lys  Cys Phe Cys Xaa Xaa  Lys Gly Ile 
    1070                 1075                 1080             


Lys Gly  Asp Gln Cys Gln Leu  Cys Asp Ser Glu Asn  Arg Tyr Val 
    1085                 1090                 1095             


Gly Asn  Pro Leu Arg Gly Xaa  Cys Tyr Tyr Ser Leu  Leu Ile Asp 
    1100                 1105                 1110             


Tyr Gln  Phe Xaa Phe Ser Leu  Leu Gln Glu Asp Asp  Arg His His 
    1115                 1120                 1125             


Xaa Ala  Ile Asn Phe Ile Ala  Asn Pro Glu Gln Ser  Asn Lys Asn 
    1130                 1135                 1140             


Leu Asp  Ile Ser Ile Asn Ala  Ser Asn Asn Phe Asn  Leu Asn Ile 
    1145                 1150                 1155             


Xaa Trp  Ser Val Gly Ser Xaa  Ala Gly Xaa Ile Ser  Gly Glu Glu 
    1160                 1165                 1170             


Xaa Ser  Ile Val Ser Lys Asn  Asn Ile Lys Glu Tyr  Arg Asp Ser 
    1175                 1180                 1185             


Phe Ser  Tyr Glu Lys Phe Asn  Phe Arg Ser Asn Pro  Asn Ile Xaa 
    1190                 1195                 1200             


Phe Tyr  Val Tyr Val Ser Asn  Phe Ser Trp Pro Ile  Lys Ile Gln 
    1205                 1210                 1215             


Ile Ala  Phe Ser Gln His Asn  Xaa Ile Met Asp Leu  Val Gln Phe 
    1220                 1225                 1230             


Phe Val  Xaa Phe Phe Ser Cys  Phe Leu Ser Leu Leu  Leu Val Ala 
    1235                 1240                 1245             


Ala Val  Val Trp Lys Ile Lys  Gln Xaa Cys Trp Ala  Ser Arg Arg 
    1250                 1255                 1260             


Arg Glu  Gln Leu Leu Arg Glu  Arg Gln Gln Met Ala  Ser Arg Pro 
    1265                 1270                 1275             


Phe Ala  Ser Val Asp Val Ala  Leu Glu Val Gly Ala  Glu Gln Xaa 
    1280                 1285                 1290             


Glu Phe  Leu Arg Gly Pro Leu  Glu Gly Ala Pro Lys  Pro Ile Ala 
    1295                 1300                 1305             


Ile Glu  Pro Cys Ala Gly Asn  Arg Ala Ala Val Leu  Xaa Val Phe 
    1310                 1315                 1320             


Leu Cys  Leu Pro Arg Gly Ser  Ser Gly Ala Pro Pro  Pro Gly Gln 
    1325                 1330                 1335             


Ser Gly  Leu Ala Ile Ala Ser  Ala Leu Ile Asp Ile  Ser Gln Gln 
    1340                 1345                 1350             


Lys Ala  Ser Asp Ser Lys Asp  Lys Xaa Ser Gly Val  Arg Asn Arg 
    1355                 1360                 1365             


Lys His  Leu Ser Xaa Arg Gln  Gly Xaa Cys Val 
    1370                 1375                 


<210> 3724
<211> 36
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<400> 3724
Met Pro Glu Cys Asp Trp Arg Gln Pro Ser Gly Gly Asp Gly Gly Trp 
1               5                   10                  15      


Asp Leu Ser Leu Leu Xaa Gly Glu Arg Asp Ser Asp Gly Arg Arg Asp 
            20                  25                  30          


Phe Ala Arg Glu 
        35      


<210> 3725
<211> 252
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<400> 3725
Met Pro Glu Cys Asp Trp Arg Gln Pro Ser Gly Gly Asp Gly Gly Trp 
1               5                   10                  15      


Asp Leu Ser Leu Leu Xaa Gly Glu Arg Asp Ser Asp Gly Arg Arg Leu 
            20                  25                  30          


Xaa Glu Pro Ser Gly Tyr Leu Xaa Asp Gly Pro Ile Asn Tyr Lys Tyr 
        35                  40                  45              


Lys Xaa Lys Cys Xaa Trp Leu Ile Glu Gly Tyr Pro Asn Ala Val Leu 
    50                  55                  60                  


Arg Leu Arg Phe Asn His Phe Ala Xaa Glu Cys Ser Trp Asp His Met 
65                  70                  75                  80  


Tyr Val Tyr Asp Gly Asp Ser Ile Tyr Ala Pro Leu Ile Ala Val Leu 
                85                  90                  95      


Ser Gly Leu Ile Val Pro Glu Ile Arg Gly Asn Glu Xaa Val Pro Glu 
            100                 105                 110         


Val Val Xaa Xaa Ser Gly Tyr Ala Leu Leu His Phe Phe Ser Asp Ala 
        115                 120                 125             


Ala Tyr Asn Leu Xaa Gly Phe Asn Ile Phe Tyr Ser Ile Asn Ser Cys 
    130                 135                 140                 


Pro Asn Asn Cys Ser Gly His Gly Lys Cys Xaa Xaa Ser Val Ser Val 
145                 150                 155                 160 


Pro Ser Gln Val Tyr Cys Glu Cys Asp Lys Tyr Trp Lys Gly Glu Ala 
                165                 170                 175     


Cys Asp Ile Pro Tyr Cys Lys Ala Asn Cys Gly Ser Pro Asp His Gly 
            180                 185                 190         


Tyr Cys Asp Leu Xaa Gly Glu Lys Leu Cys Val Cys Asn Asp Ser Trp 
        195                 200                 205             


Gln Gly Pro Asp Cys Ser Leu Asn Val Pro Ser Xaa Glu Ser Tyr Trp 
    210                 215                 220                 


Ile Leu Pro Asn Val Lys Pro Phe Ser Pro Ser Val Gly Arg Ala Ser 
225                 230                 235                 240 


His Lys Ala Val Leu His Gly Lys Phe Met Trp Val 
                245                 250         


<210> 3726
<211> 216
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<400> 3726
Xaa Cys Glu Lys Pro Val Val Ser Pro Asn Gln Asn Ala Arg Pro Cys 
1               5                   10                  15      


Lys Lys Pro Cys Ser Leu Arg Xaa Ser Cys Ser Asn Cys Xaa Ser Asn 
            20                  25                  30          


Gly Met Glu Cys Met Trp Cys Ser Ser Xaa Lys Arg Cys Val Asp Ser 
        35                  40                  45              


Asn Ala Tyr Ile Ile Ser Phe Pro Tyr Gly Gln Cys Leu Glu Trp Gln 
    50                  55                  60                  


Xaa Ala Xaa Cys Ser Pro Gln Asn Cys Ser Gly Leu Arg Xaa Cys Gly 
65                  70                  75                  80  


Gln Cys Leu Glu Gln Pro Gly Cys Gly Trp Cys Asn Asp Pro Ser Asn 
                85                  90                  95      


Xaa Gly Arg Gly His Cys Ile Glu Gly Ser Ser Arg Gly Pro Met Lys 
            100                 105                 110         


Leu Ile Gly Met His His Ser Glu Met Val Leu Asp Xaa Asn Leu Cys 
        115                 120                 125             


Pro Lys Glu Lys Asn Tyr Glu Trp Ser Phe Ile Gln Cys Pro Ala Cys 
    130                 135                 140                 


Xaa Cys Ser Gly His Ala Asn Ile Cys His Leu His Xaa Gly Lys Cys 
145                 150                 155                 160 


Phe Cys Xaa Xaa Lys Gly Ile Lys Gly Asp Gln Cys Gln Leu Cys Asp 
                165                 170                 175     


Ser Glu Asn Arg Tyr Val Gly Asn Pro Leu Arg Gly Xaa Cys Tyr Tyr 
            180                 185                 190         


Ser Leu Leu Ile Asp Tyr Gln Phe Xaa Phe Ser Leu Leu Gln Glu Asp 
        195                 200                 205             


Asp Arg His His Xaa Ala Ile Asn 
    210                 215     


<210> 3727
<211> 198
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<400> 3727
Glu Asp Gly Gly Val Met Ile Ile Gly Tyr Glu Met Tyr Arg Asn Leu 
1               5                   10                  15      


Ala Gln Gly Arg Asn Val Lys Ser Arg Lys Leu Lys Glu Ile Phe Asn 
            20                  25                  30          


Lys Ala Leu Val Asp Pro Gly Pro Asp Phe Val Val Cys Asp Glu Gly 
        35                  40                  45              


His Ile Leu Lys Asn Glu Ala Ser Ala Val Ser Lys Ala Met Asn Ser 
    50                  55                  60                  


Ile Arg Ser Arg Arg Arg Ile Ile Leu Xaa Gly Xaa Pro Leu Gln Asn 
65                  70                  75                  80  


Asn Leu Ile Glu Tyr His Cys Met Val Asn Phe Ile Lys Glu Asn Leu 
                85                  90                  95      


Leu Gly Ser Ile Lys Glu Phe Arg Asn Arg Phe Ile Asn Pro Ile Gln 
            100                 105                 110         


Asn Gly Gln Cys Ala Asp Ser Xaa Met Val Asp Val Arg Val Met Lys 
        115                 120                 125             


Lys Arg Ala His Ile Leu Tyr Glu Met Leu Ala Gly Cys Val Gln Arg 
    130                 135                 140                 


Lys Asp Tyr Xaa Ala Leu Xaa Lys Phe Leu Pro Pro Lys His Glu Tyr 
145                 150                 155                 160 


Val Leu Ala Val Arg Met Xaa Ser Ile Gln Cys Lys Leu Tyr Gln Tyr 
                165                 170                 175     


Tyr Leu Asp His Leu Xaa Val Leu His Leu Asn Lys Met Gly Met Leu 
            180                 185                 190         


Lys Ser Ile Lys Tyr Phe 
        195             


<210> 3728
<211> 6
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<400> 3728
Lys Arg Gly Asp Leu Xaa 
1               5       


<210> 3729
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<400> 3729
Met Met Glu Asn Ser Lys Glu Glu Gly Xaa Ser Ser Ser Glu Lys Ser 
1               5                   10                  15      


Lys Ser Ser Gly Ser Ser Arg Ser Lys Arg Lys Pro Ser Ile Val Xaa 
            20                  25                  30          


Lys Tyr Val Glu Ser Asp Asp Glu Lys Pro Leu Asp Asp Glu Xaa Val 
        35                  40                  45              


Asn Glu Asp Ala Ser Asn Glu Asn Ser Glu Asn Asp Ile Xaa Met Gln 
    50                  55                  60                  


Ser Leu Pro Lys Glu Asp Gly Leu His Gly Ile Val Ser Cys Xaa Ala 
65                  70                  75                  80  


Cys Gly Gln Gln Val Asn His Phe Gln Lys Asp Ser Ile Tyr Arg His 
                85                  90                  95      


Pro Ser Leu Gln Val Leu Ile Cys Lys Asn Cys Phe 
            100                 105             


<210> 3730
<211> 528
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<400> 3730
Met Met Glu Asn Ser Lys Glu Glu Gly Xaa Ser Ser Ser Glu Lys Ser 
1               5                   10                  15      


Lys Ser Ser Gly Ser Ser Arg Ser Lys Arg Lys Pro Ser Ile Val Xaa 
            20                  25                  30          


Lys Tyr Val Glu Ser Asp Asp Glu Lys Pro Leu Asp Asp Glu Xaa Val 
        35                  40                  45              


Asn Glu Asp Ala Ser Asn Glu Asn Ser Glu Asn Asp Ile Xaa Met Gln 
    50                  55                  60                  


Ser Leu Pro Lys Gly Xaa Val Ile Val Gln Pro Glu Pro Val Leu Asn 
65                  70                  75                  80  


Glu Asp Lys Asp Asp Phe Lys Gly Pro Glu Phe Arg Ser Arg Ser Lys 
                85                  90                  95      


Met Lys Xaa Glu Asn Leu Lys Lys Arg Gly Glu Asp Gly Leu His Gly 
            100                 105                 110         


Ile Val Ser Cys Xaa Ala Cys Gly Gln Gln Val Asn His Phe Gln Lys 
        115                 120                 125             


Asp Ser Ile Tyr Arg His Pro Ser Leu Gln Val Leu Ile Cys Lys Asn 
    130                 135                 140                 


Cys Phe Lys Tyr Tyr Met Ser Asp Asp Ile Ser Arg Asp Ser Asp Gly 
145                 150                 155                 160 


Met Asp Glu Gln Cys Arg Trp Cys Ala Glu Gly Gly Asn Leu Ile Cys 
                165                 170                 175     


Cys Asp Phe Cys His Asn Ala Phe Cys Lys Lys Cys Ile Leu Arg Asn 
            180                 185                 190         


Leu Gly Arg Lys Glu Leu Ser Xaa Ile Met Asp Glu Asn Asn Gln Trp 
        195                 200                 205             


Tyr Cys Tyr Ile Cys His Pro Glu Pro Leu Leu Asp Leu Val Xaa Ala 
    210                 215                 220                 


Cys Asn Ser Val Phe Glu Asn Leu Glu Gln Leu Leu Gln Gln Asn Lys 
225                 230                 235                 240 


Lys Lys Ile Lys Val Asp Ser Glu Lys Ser Asn Lys Val Tyr Glu His 
                245                 250                 255     


Xaa Ser Arg Phe Ser Pro Lys Lys Xaa Ser Ser Asn Cys Asn Gly Glu 
            260                 265                 270         


Glu Lys Lys Leu Asp Asp Ser Cys Ser Gly Ser Val Xaa Tyr Ser Tyr 
        275                 280                 285             


Ser Ala Leu Ile Val Pro Lys Glu Met Ile Lys Lys Ala Lys Lys Leu 
    290                 295                 300                 


Ile Glu Xaa Xaa Ala Asn Met Asn Ser Ser Tyr Val Lys Phe Leu Lys 
305                 310                 315                 320 


Gln Ala Xaa Asp Asn Ser Glu Ile Ser Ser Ala Xaa Lys Leu Arg Gln 
                325                 330                 335     


Leu Lys Ala Phe Lys Ser Val Leu Ala Asp Ile Lys Lys Ala His Leu 
            340                 345                 350         


Ala Leu Glu Glu Asp Leu Asn Ser Glu Phe Arg Ala Met Asp Ala Val 
        355                 360                 365             


Asn Lys Glu Lys Asn Xaa Lys Glu His Lys Val Ile Asp Ala Lys Phe 
    370                 375                 380                 


Glu Xaa Lys Ala Arg Lys Gly Glu Lys Pro Cys Ala Leu Glu Lys Lys 
385                 390                 395                 400 


Asp Ile Ser Lys Ser Glu Ala Lys Leu Ser Arg Lys Gln Val Asp Ser 
                405                 410                 415     


Glu His Met His Gln Asn Val Pro Xaa Glu Glu Gln Arg Xaa Asn Lys 
            420                 425                 430         


Ser Xaa Gly Gly Glu His Lys Lys Ser Asp Arg Lys Glu Glu Pro Gln 
        435                 440                 445             


Tyr Glu Pro Ala Asn Xaa Ser Glu Asp Leu Asp Met Asp Ile Val Ser 
    450                 455                 460                 


Val Pro Ser Ser Val Pro Glu Asp Ile Phe Glu Asn Leu Glu Xaa Ala 
465                 470                 475                 480 


Met Glu Val Gln Ser Ser Val Asp His Gln Gly Asp Gly Ser Ser Gly 
                485                 490                 495     


Xaa Glu Gln Glu Val Glu Ser Ser Ser Val Lys Leu Asn Ile Ser Ser 
            500                 505                 510         


Lys Asp Asn Arg Gly Gly Ile Lys Ser Lys Xaa Xaa Ala Lys Val Xaa 
        515                 520                 525             


<210> 3731
<211> 47
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<400> 3731
Met Asn Gln Asn Xaa Asp Lys Ile Ser Gly Ser Gly Ser Asn Ser Asp 
1               5                   10                  15      


Met Met Glu Asn Ser Lys Glu Glu Gly Xaa Ser Ser Ser Glu Lys Ser 
            20                  25                  30          


Lys Ser Ser Gly Ser Ser Arg Ser Lys Arg Lys Pro Ser Ile Val 
        35                  40                  45          


<210> 3732
<211> 1351
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1123)..(1123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1189)..(1189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1235)..(1235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1278)..(1278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<400> 3732
Met Xaa Ala Glu Pro Met Ser Glu Ser Lys Leu Asn Xaa Leu Val Gln 
1               5                   10                  15      


Lys Leu His Asp Phe Leu Ala His Ser Ser Glu Glu Ser Glu Glu Xaa 
            20                  25                  30          


Ser Ser Pro Pro Arg Leu Ala Met Asn Gln Asn Xaa Asp Lys Ile Ser 
        35                  40                  45              


Gly Ser Gly Ser Asn Ser Asp Met Met Glu Asn Ser Lys Glu Glu Gly 
    50                  55                  60                  


Xaa Ser Ser Ser Glu Lys Ser Lys Ser Ser Gly Ser Ser Arg Ser Lys 
65                  70                  75                  80  


Arg Lys Pro Ser Ile Val Xaa Lys Tyr Val Glu Ser Asp Asp Glu Lys 
                85                  90                  95      


Pro Leu Asp Asp Glu Xaa Val Asn Glu Asp Ala Ser Asn Glu Asn Ser 
            100                 105                 110         


Glu Asn Asp Ile Xaa Met Gln Ser Leu Pro Lys Asp Gly Leu His Gly 
        115                 120                 125             


Ile Val Ser Cys Xaa Ala Cys Gly Gln Gln Val Asn His Phe Gln Lys 
    130                 135                 140                 


Asp Ser Ile Tyr Arg His Pro Ser Leu Gln Val Leu Ile Cys Lys Asn 
145                 150                 155                 160 


Cys Phe Lys Tyr Tyr Met Ser Asp Asp Ile Ser Arg Asp Ser Asp Gly 
                165                 170                 175     


Met Asp Glu Gln Cys Arg Trp Cys Ala Glu Gly Gly Asn Leu Ile Cys 
            180                 185                 190         


Cys Asp Phe Cys His Asn Ala Phe Cys Lys Lys Cys Ile Leu Arg Asn 
        195                 200                 205             


Leu Gly Arg Lys Glu Leu Ser Xaa Ile Met Asp Glu Asn Asn Gln Trp 
    210                 215                 220                 


Tyr Cys Tyr Ile Cys His Pro Glu Pro Leu Leu Asp Leu Val Xaa Ala 
225                 230                 235                 240 


Cys Asn Ser Val Phe Glu Asn Leu Glu Gln Leu Leu Gln Gln Asn Lys 
                245                 250                 255     


Lys Lys Ile Lys Val Asp Ser Glu Lys Ser Asn Lys Val Tyr Glu His 
            260                 265                 270         


Xaa Ser Arg Phe Ser Pro Lys Lys Xaa Ser Ser Asn Cys Asn Gly Glu 
        275                 280                 285             


Glu Lys Lys Leu Asp Asp Ser Cys Ser Gly Ser Val Xaa Tyr Ser Tyr 
    290                 295                 300                 


Ser Ala Leu Ile Val Pro Lys Glu Met Ile Lys Lys Ala Lys Lys Leu 
305                 310                 315                 320 


Ile Glu Xaa Xaa Ala Asn Met Asn Ser Ser Tyr Val Lys Phe Leu Lys 
                325                 330                 335     


Gln Ala Xaa Asp Asn Ser Glu Ile Ser Ser Ala Xaa Lys Leu Arg Gln 
            340                 345                 350         


Leu Lys Ala Phe Lys Ser Val Leu Ala Asp Ile Lys Lys Ala His Leu 
        355                 360                 365             


Ala Leu Glu Glu Asp Leu Asn Ser Glu Phe Arg Ala Met Asp Ala Val 
    370                 375                 380                 


Asn Lys Glu Lys Asn Xaa Lys Glu His Lys Val Ile Asp Ala Lys Phe 
385                 390                 395                 400 


Glu Xaa Lys Ala Arg Lys Gly Glu Lys Pro Cys Ala Leu Glu Lys Lys 
                405                 410                 415     


Asp Ile Ser Lys Ser Glu Ala Lys Leu Ser Arg Lys Gln Val Asp Ser 
            420                 425                 430         


Glu His Met His Gln Asn Val Pro Xaa Glu Glu Gln Arg Xaa Asn Lys 
        435                 440                 445             


Ser Xaa Gly Gly Glu His Lys Lys Ser Asp Arg Lys Glu Glu Pro Gln 
    450                 455                 460                 


Tyr Glu Pro Ala Asn Xaa Ser Glu Asp Leu Asp Met Asp Ile Val Ser 
465                 470                 475                 480 


Val Pro Ser Ser Val Pro Glu Asp Ile Phe Glu Asn Leu Glu Xaa Ala 
                485                 490                 495     


Met Glu Val Gln Ser Ser Val Asp His Gln Gly Asp Gly Ser Ser Gly 
            500                 505                 510         


Xaa Glu Gln Glu Val Glu Ser Ser Ser Val Lys Leu Asn Ile Ser Ser 
        515                 520                 525             


Lys Asp Asn Arg Gly Gly Ala Asp Cys Gln Glu Val Pro Gln Asp Lys 
    530                 535                 540                 


Asp Gly Tyr Lys Ser Cys Gly Leu Asn Pro Lys Leu Glu Lys Cys Gly 
545                 550                 555                 560 


Leu Gly Gln Glu Asn Ser Asp Asn Glu His Leu Val Glu Asn Glu Val 
                565                 570                 575     


Ser Leu Leu Leu Glu Glu Ser Asp Leu Arg Arg Ser Pro Arg Val Lys 
            580                 585                 590         


Xaa Xaa Pro Leu Arg Arg Pro Xaa Glu Xaa Asn Pro Val Xaa Ser Asn 
        595                 600                 605             


Ser Asp Glu Glu Cys Asn Glu Xaa Val Lys Glu Lys Gln Lys Leu Ser 
    610                 615                 620                 


Val Pro Val Arg Lys Lys Asp Lys Arg Asn Ser Ser Asp Ser Ala Ile 
625                 630                 635                 640 


Asp Asn Pro Lys Pro Asn Lys Leu Pro Lys Ser Lys Gln Ser Glu Xaa 
                645                 650                 655     


Val Asp Gln Asn Ser Asp Ser Asp Glu Met Leu Ala Ile Leu Lys Glu 
            660                 665                 670         


Val Ser Arg Met Ser His Ser Ser Ser Ser Asp Xaa Asp Ile Asn Glu 
        675                 680                 685             


Ile His Xaa Asn His Lys Xaa Leu Tyr Asp Leu Lys Xaa Gln Ala Gly 
    690                 695                 700                 


Lys Asp Asp Lys Gly Lys Arg Lys Arg Lys Ser Ser Xaa Ser Gly Ser 
705                 710                 715                 720 


Asp Phe Asp Xaa Lys Lys Gly Lys Ser Ala Lys Ser Ser Ile Ile Ser 
                725                 730                 735     


Lys Lys Lys Arg Gln Xaa Gln Ser Glu Ser Ser Asn Tyr Asp Ser Glu 
            740                 745                 750         


Leu Glu Lys Glu Ile Lys Ser Met Ser Lys Ile Gly Ala Ala Arg Xaa 
        755                 760                 765             


Xaa Lys Lys Arg Ile Pro Asn Xaa Lys Asp Phe Asp Ser Ser Glu Asp 
    770                 775                 780                 


Glu Lys His Ser Lys Lys Gly Met Asp Asn Gln Gly His Lys Asn Leu 
785                 790                 795                 800 


Lys Xaa Ser Gln Glu Gly Ser Ser Asp Asp Ala Glu Arg Lys Gln Glu 
                805                 810                 815     


Arg Glu Xaa Phe Ser Ser Ala Glu Gly Xaa Val Asp Lys Asp Xaa Xaa 
            820                 825                 830         


Ile Met Glu Leu Arg Asp Arg Leu Pro Lys Lys Gln Gln Ala Ser Ala 
        835                 840                 845             


Ser Xaa Asp Gly Val Asp Lys Leu Ser Gly Lys Glu Glu Ser Phe Xaa 
    850                 855                 860                 


Ser Leu Glu Val Arg Lys Val Ala Glu Xaa Lys Glu Lys Ser Lys His 
865                 870                 875                 880 


Leu Lys Xaa Lys Xaa Cys Lys Lys Val Gln Asp Gly Leu Ser Asp Ile 
                885                 890                 895     


Ala Glu Lys Phe Leu Lys Lys Asp Gln Ser Asp Glu Xaa Ser Glu Asp 
            900                 905                 910         


Asp Lys Lys Gln Ser Lys Lys Gly Xaa Glu Glu Lys Lys Lys Pro Ser 
        915                 920                 925             


Asp Phe Lys Lys Lys Val Ile Lys Met Glu Gln Gln Tyr Glu Ser Ser 
    930                 935                 940                 


Ser Asp Gly Xaa Glu Lys Leu Pro Glu Arg Glu Glu Ile Cys His Phe 
945                 950                 955                 960 


Pro Lys Gly Ile Lys Gln Ile Lys Asn Gly Xaa Xaa Asp Gly Glu Lys 
                965                 970                 975     


Lys Ser Lys Lys Ile Arg Asp Lys Xaa Ser Lys Lys Lys Asp Glu Leu 
            980                 985                 990         


Ser Asp Tyr Ala Glu Lys Ser Xaa  Gly Lys Gly Asp Ser  Cys Asp Ser 
        995                 1000                 1005             


Ser Glu  Asp Lys Lys Ser Lys  Asn Gly Ala Tyr Gly  Arg Glu Lys 
    1010                 1015                 1020             


Lys Arg  Cys Lys Leu Leu Gly  Lys Ser Ser Arg Lys  Arg Gln Asp 
    1025                 1030                 1035             


Cys Ser  Ser Ser Asp Xaa Glu  Lys Tyr Ser Met Lys  Glu Asp Gly 
    1040                 1045                 1050             


Cys Asn  Ser Ser Asp Lys Arg  Leu Lys Arg Ile Glu  Leu Arg Glu 
    1055                 1060                 1065             


Arg Arg  Asn Leu Ser Ser Lys  Arg Asn Xaa Lys Glu  Ile Gln Ser 
    1070                 1075                 1080             


Gly Ser  Ser Ser Ser Asp Ala  Glu Glu Ser Ser Glu  Asp Asn Lys 
    1085                 1090                 1095             


Lys Lys  Lys Gln Arg Xaa Ser  Ser Lys Lys Lys Ala  Val Ile Val 
    1100                 1105                 1110             


Lys Glu  Lys Lys Arg Asn Ser  Leu Arg Xaa Ser Xaa  Lys Arg Lys 
    1115                 1120                 1125             


Gln Ala  Asp Ile Xaa Ser Ser  Ser Ser Ser Asp Ile  Glu Asp Asp 
    1130                 1135                 1140             


Asp Gln  Asn Ser Ile Gly Glu  Gly Ser Ser Asp Glu  Gln Lys Ile 
    1145                 1150                 1155             


Lys Pro  Val Xaa Glu Asn Leu  Val Leu Ser Ser His  Xaa Gly Phe 
    1160                 1165                 1170             


Cys Gln  Ser Ser Gly Asp Glu  Ala Leu Ser Lys Ser  Val Pro Val 
    1175                 1180                 1185             


Xaa Val  Asp Asp Asp Asp Asp  Asp Asn Asp Pro Glu  Asn Arg Ile 
    1190                 1195                 1200             


Ala Lys  Lys Met Leu Leu Glu  Glu Ile Lys Ala Asn  Leu Ser Ser 
    1205                 1210                 1215             


Asp Glu  Asp Gly Ser Ser Asp  Asp Glu Pro Glu Glu  Gly Lys Lys 
    1220                 1225                 1230             


Arg Xaa  Gly Lys Gln Asn Glu  Glu Asn Pro Gly Asp  Glu Glu Ala 
    1235                 1240                 1245             


Lys Asn  Gln Val Asn Ser Glu  Ser Asp Ser Asp Ser  Glu Glu Ser 
    1250                 1255                 1260             


Lys Lys  Pro Arg Tyr Arg His  Arg Leu Leu Arg His  Lys Leu Xaa 
    1265                 1270                 1275             


Val Ser  Asp Gly Glu Ser Gly  Glu Glu Lys Lys Xaa  Lys Pro Lys 
    1280                 1285                 1290             


Glu His  Lys Glu Val Lys Gly  Arg Asn Arg Arg Lys  Val Ser Ser 
    1295                 1300                 1305             


Glu Asp  Ser Glu Asp Ser Asp  Phe Gln Glu Ser Gly  Val Ser Glu 
    1310                 1315                 1320             


Glu Val  Ser Glu Ser Glu Asp  Glu Gln Arg Pro Arg  Xaa Arg Ser 
    1325                 1330                 1335             


Ala Lys  Lys Ala Glu Leu Glu  Glu Asn Gln Arg Ser  Tyr 
    1340                 1345                 1350     


<210> 3733
<211> 2454
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1108)..(1108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1308)..(1308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1320)..(1320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1366)..(1366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1453)..(1453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1491)..(1491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1496)..(1497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1507)..(1507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1544)..(1544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1563)..(1563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1572)..(1572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1583)..(1583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1592)..(1592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1620)..(1620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1709)..(1709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1711)..(1711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1755)..(1755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1783)..(1783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1786)..(1786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1802)..(1802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1817)..(1817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1846)..(1846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1880)..(1880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1890)..(1890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1935)..(1935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1951)..(1951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1969)..(1969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2024)..(2024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2052)..(2053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2068)..(2068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2079)..(2079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2119)..(2119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2132)..(2132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2143)..(2143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2162)..(2162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2167)..(2167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2171)..(2171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2190)..(2190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2197)..(2197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2229)..(2229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2248)..(2248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2255)..(2255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2257)..(2257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2268)..(2268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2301)..(2301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2305)..(2305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2358)..(2358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2389)..(2389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2394)..(2394)
<223> Selenocysteine

<400> 3733
Met Xaa Ala Glu Pro Met Ser Glu Ser Lys Leu Asn Xaa Leu Val Gln 
1               5                   10                  15      


Lys Leu His Asp Phe Leu Ala His Ser Ser Glu Glu Ser Glu Glu Xaa 
            20                  25                  30          


Ser Ser Pro Pro Arg Leu Ala Met Asn Gln Asn Xaa Asp Lys Ile Ser 
        35                  40                  45              


Gly Ser Gly Ser Asn Ser Asp Met Met Glu Asn Ser Lys Glu Glu Gly 
    50                  55                  60                  


Xaa Ser Ser Ser Glu Lys Ser Lys Ser Ser Gly Ser Ser Arg Ser Lys 
65                  70                  75                  80  


Arg Lys Pro Ser Ile Val Xaa Lys Tyr Val Glu Ser Asp Asp Glu Lys 
                85                  90                  95      


Pro Leu Asp Asp Glu Xaa Val Asn Glu Asp Ala Ser Asn Glu Asn Ser 
            100                 105                 110         


Glu Asn Asp Ile Xaa Met Gln Ser Leu Pro Lys Glu Asp Gly Leu His 
        115                 120                 125             


Gly Ile Val Ser Cys Xaa Ala Cys Gly Gln Gln Val Asn His Phe Gln 
    130                 135                 140                 


Lys Asp Ser Ile Tyr Arg His Pro Ser Leu Gln Val Leu Ile Cys Lys 
145                 150                 155                 160 


Asn Cys Phe Lys Tyr Tyr Met Ser Asp Asp Ile Ser Arg Asp Ser Asp 
                165                 170                 175     


Gly Met Asp Glu Gln Cys Arg Trp Cys Ala Glu Gly Gly Asn Leu Ile 
            180                 185                 190         


Cys Cys Asp Phe Cys His Asn Ala Phe Cys Lys Lys Cys Ile Leu Arg 
        195                 200                 205             


Asn Leu Gly Arg Lys Glu Leu Ser Xaa Ile Met Asp Glu Asn Asn Gln 
    210                 215                 220                 


Trp Tyr Cys Tyr Ile Cys His Pro Glu Pro Leu Leu Asp Leu Val Xaa 
225                 230                 235                 240 


Ala Cys Asn Ser Val Phe Glu Asn Leu Glu Gln Leu Leu Gln Gln Asn 
                245                 250                 255     


Lys Lys Lys Ile Lys Val Asp Ser Glu Lys Ser Asn Lys Val Tyr Glu 
            260                 265                 270         


His Xaa Ser Arg Phe Ser Pro Lys Lys Xaa Ser Ser Asn Cys Asn Gly 
        275                 280                 285             


Glu Glu Lys Lys Leu Asp Asp Ser Cys Ser Gly Ser Val Xaa Tyr Ser 
    290                 295                 300                 


Tyr Ser Ala Leu Ile Val Pro Lys Glu Met Ile Lys Lys Ala Lys Lys 
305                 310                 315                 320 


Leu Ile Glu Xaa Xaa Ala Asn Met Asn Ser Ser Tyr Val Lys Phe Leu 
                325                 330                 335     


Lys Gln Ala Xaa Asp Asn Ser Glu Ile Ser Ser Ala Xaa Lys Leu Arg 
            340                 345                 350         


Gln Leu Lys Ala Phe Lys Ser Val Leu Ala Asp Ile Lys Lys Ala His 
        355                 360                 365             


Leu Ala Leu Glu Glu Asp Leu Asn Ser Glu Phe Arg Ala Met Asp Ala 
    370                 375                 380                 


Val Asn Lys Glu Lys Asn Xaa Lys Glu His Lys Val Ile Asp Ala Lys 
385                 390                 395                 400 


Phe Glu Xaa Lys Ala Arg Lys Gly Glu Lys Pro Cys Ala Leu Glu Lys 
                405                 410                 415     


Lys Asp Ile Ser Lys Ser Glu Ala Lys Leu Ser Arg Lys Gln Val Asp 
            420                 425                 430         


Ser Glu His Met His Gln Asn Val Pro Xaa Glu Glu Gln Arg Xaa Asn 
        435                 440                 445             


Lys Ser Xaa Gly Gly Glu His Lys Lys Ser Asp Arg Lys Glu Glu Pro 
    450                 455                 460                 


Gln Tyr Glu Pro Ala Asn Xaa Ser Glu Asp Leu Asp Met Asp Ile Val 
465                 470                 475                 480 


Ser Val Pro Ser Ser Val Pro Glu Asp Ile Phe Glu Asn Leu Glu Xaa 
                485                 490                 495     


Ala Met Glu Val Gln Ser Ser Val Asp His Gln Gly Asp Gly Ser Ser 
            500                 505                 510         


Gly Xaa Glu Gln Glu Val Glu Ser Ser Ser Val Lys Leu Asn Ile Ser 
        515                 520                 525             


Ser Lys Asp Asn Arg Gly Gly Ile Lys Ser Lys Xaa Xaa Ala Lys Val 
    530                 535                 540                 


Xaa Lys Glu Leu Tyr Val Lys Leu Xaa Pro Val Ser Leu Ser Asn Ser 
545                 550                 555                 560 


Pro Ile Lys Gly Ala Asp Cys Gln Glu Val Pro Gln Asp Lys Asp Gly 
                565                 570                 575     


Tyr Lys Ser Cys Gly Leu Asn Pro Lys Leu Glu Lys Cys Gly Leu Gly 
            580                 585                 590         


Gln Glu Asn Ser Asp Asn Glu His Leu Val Glu Asn Glu Val Ser Leu 
        595                 600                 605             


Leu Leu Glu Glu Ser Asp Leu Arg Arg Ser Pro Arg Val Lys Xaa Xaa 
    610                 615                 620                 


Pro Leu Arg Arg Pro Xaa Glu Xaa Asn Pro Val Xaa Ser Asn Ser Asp 
625                 630                 635                 640 


Glu Glu Cys Asn Glu Xaa Val Lys Glu Lys Gln Lys Leu Ser Val Pro 
                645                 650                 655     


Val Arg Lys Lys Asp Lys Arg Asn Ser Ser Asp Ser Ala Ile Asp Asn 
            660                 665                 670         


Pro Lys Pro Asn Lys Leu Pro Lys Ser Lys Gln Ser Glu Xaa Val Asp 
        675                 680                 685             


Gln Asn Ser Asp Ser Asp Glu Met Leu Ala Ile Leu Lys Glu Val Ser 
    690                 695                 700                 


Arg Met Ser His Ser Ser Ser Ser Asp Xaa Asp Ile Asn Glu Ile His 
705                 710                 715                 720 


Xaa Asn His Lys Xaa Leu Tyr Asp Leu Lys Xaa Gln Ala Gly Lys Asp 
                725                 730                 735     


Asp Lys Gly Lys Arg Lys Arg Lys Ser Ser Xaa Ser Gly Ser Asp Phe 
            740                 745                 750         


Asp Xaa Lys Lys Gly Lys Ser Ala Lys Ser Ser Ile Ile Ser Lys Lys 
        755                 760                 765             


Lys Arg Gln Xaa Gln Ser Glu Ser Ser Asn Tyr Asp Ser Glu Leu Glu 
    770                 775                 780                 


Lys Glu Ile Lys Ser Met Ser Lys Ile Gly Ala Ala Arg Xaa Xaa Lys 
785                 790                 795                 800 


Lys Arg Ile Pro Asn Xaa Lys Asp Phe Asp Ser Ser Glu Asp Glu Lys 
                805                 810                 815     


His Ser Lys Lys Gly Met Asp Asn Gln Gly His Lys Asn Leu Lys Xaa 
            820                 825                 830         


Ser Gln Glu Gly Ser Ser Asp Asp Ala Glu Arg Lys Gln Glu Arg Glu 
        835                 840                 845             


Xaa Phe Ser Ser Ala Glu Gly Xaa Val Asp Lys Asp Xaa Xaa Ile Met 
    850                 855                 860                 


Glu Leu Arg Asp Arg Leu Pro Lys Lys Gln Gln Ala Ser Ala Ser Xaa 
865                 870                 875                 880 


Asp Gly Val Asp Lys Leu Ser Gly Lys Glu Glu Ser Phe Xaa Ser Leu 
                885                 890                 895     


Glu Val Arg Lys Val Ala Glu Xaa Lys Glu Lys Ser Lys His Leu Lys 
            900                 905                 910         


Xaa Lys Xaa Cys Lys Lys Val Gln Asp Gly Leu Ser Asp Ile Ala Glu 
        915                 920                 925             


Lys Phe Leu Lys Lys Asp Gln Ser Asp Glu Xaa Ser Glu Asp Asp Lys 
    930                 935                 940                 


Lys Gln Ser Lys Lys Gly Xaa Glu Glu Lys Lys Lys Pro Ser Asp Phe 
945                 950                 955                 960 


Lys Lys Lys Val Ile Lys Met Glu Gln Gln Tyr Glu Ser Ser Ser Asp 
                965                 970                 975     


Gly Xaa Glu Lys Leu Pro Glu Arg Glu Glu Ile Cys His Phe Pro Lys 
            980                 985                 990         


Gly Ile Lys Gln Ile Lys Asn Gly  Xaa Xaa Asp Gly Glu  Lys Lys Ser 
        995                 1000                 1005             


Lys Lys  Ile Arg Asp Lys Xaa  Ser Lys Lys Lys Asp  Glu Leu Ser 
    1010                 1015                 1020             


Asp Tyr  Ala Glu Lys Ser Xaa  Gly Lys Gly Asp Ser  Cys Asp Ser 
    1025                 1030                 1035             


Ser Glu  Asp Lys Lys Ser Lys  Asn Gly Ala Tyr Gly  Arg Glu Lys 
    1040                 1045                 1050             


Lys Arg  Cys Lys Leu Leu Gly  Lys Ser Ser Arg Lys  Arg Gln Asp 
    1055                 1060                 1065             


Cys Ser  Ser Ser Asp Xaa Glu  Lys Tyr Ser Met Lys  Glu Asp Gly 
    1070                 1075                 1080             


Cys Asn  Ser Ser Asp Lys Arg  Leu Lys Arg Ile Glu  Leu Arg Glu 
    1085                 1090                 1095             


Arg Arg  Asn Leu Ser Ser Lys  Arg Asn Xaa Lys Glu  Ile Gln Ser 
    1100                 1105                 1110             


Gly Ser  Ser Ser Ser Asp Ala  Glu Glu Ser Ser Glu  Asp Asn Lys 
    1115                 1120                 1125             


Lys Lys  Lys Gln Arg Xaa Ser  Ser Lys Lys Lys Ala  Val Ile Val 
    1130                 1135                 1140             


Lys Glu  Lys Lys Arg Asn Ser  Leu Arg Xaa Ser Xaa  Lys Arg Lys 
    1145                 1150                 1155             


Gln Ala  Asp Ile Xaa Ser Ser  Ser Ser Ser Asp Ile  Glu Asp Asp 
    1160                 1165                 1170             


Asp Gln  Asn Ser Ile Gly Glu  Gly Ser Ser Asp Glu  Gln Lys Ile 
    1175                 1180                 1185             


Lys Pro  Val Xaa Glu Asn Leu  Val Leu Ser Ser His  Xaa Gly Phe 
    1190                 1195                 1200             


Cys Gln  Ser Ser Gly Asp Glu  Ala Leu Ser Lys Ser  Val Pro Val 
    1205                 1210                 1215             


Xaa Val  Asp Asp Asp Asp Asp  Asp Asn Asp Pro Glu  Asn Arg Ile 
    1220                 1225                 1230             


Ala Lys  Lys Met Leu Leu Glu  Glu Ile Lys Ala Asn  Leu Ser Ser 
    1235                 1240                 1245             


Asp Glu  Asp Gly Ser Ser Asp  Asp Glu Pro Glu Glu  Gly Lys Lys 
    1250                 1255                 1260             


Arg Xaa  Gly Lys Gln Asn Glu  Glu Asn Pro Gly Asp  Glu Glu Ala 
    1265                 1270                 1275             


Lys Asn  Gln Val Asn Ser Glu  Ser Asp Ser Asp Ser  Glu Glu Ser 
    1280                 1285                 1290             


Lys Lys  Pro Arg Tyr Arg His  Arg Leu Leu Arg His  Lys Leu Xaa 
    1295                 1300                 1305             


Val Ser  Asp Gly Glu Ser Gly  Glu Glu Lys Lys Xaa  Lys Pro Lys 
    1310                 1315                 1320             


Glu His  Lys Glu Val Lys Gly  Arg Asn Arg Arg Lys  Val Ser Ser 
    1325                 1330                 1335             


Glu Asp  Ser Glu Asp Ser Asp  Phe Gln Glu Ser Gly  Val Ser Glu 
    1340                 1345                 1350             


Glu Val  Ser Glu Ser Glu Asp  Glu Gln Arg Pro Arg  Xaa Arg Ser 
    1355                 1360                 1365             


Ala Lys  Lys Ala Glu Leu Glu  Glu Asn Gln Arg Ser  Tyr Lys Gln 
    1370                 1375                 1380             


Lys Lys  Lys Arg Arg Arg Ile  Lys Val Gln Glu Asp  Ser Ser Ser 
    1385                 1390                 1395             


Glu Asn  Lys Ser Asn Ser Glu  Glu Glu Glu Glu Glu  Lys Glu Glu 
    1400                 1405                 1410             


Glu Glu  Glu Glu Glu Glu Glu  Glu Glu Glu Glu Glu  Glu Asp Glu 
    1415                 1420                 1425             


Asn Asp  Asp Ser Lys Ser Pro  Gly Lys Gly Arg Lys  Lys Ile Arg 
    1430                 1435                 1440             


Lys Ile  Leu Lys Asp Asp Lys  Leu Arg Xaa Glu Xaa  Gln Asn Ala 
    1445                 1450                 1455             


Leu Lys  Glu Glu Glu Glu Arg  Arg Lys Arg Ile Ala  Glu Arg Glu 
    1460                 1465                 1470             


Arg Glu  Arg Glu Lys Leu Arg  Glu Val Ile Glu Ile  Glu Asp Ala 
    1475                 1480                 1485             


Ser Pro  Xaa Lys Cys Pro Ile  Xaa Xaa Lys Leu Val  Leu Asp Glu 
    1490                 1495                 1500             


Asp Glu  Glu Xaa Lys Glu Pro  Leu Val Gln Val His  Arg Asn Met 
    1505                 1510                 1515             


Val Ile  Lys Leu Lys Pro His  Gln Val Asp Gly Val  Gln Phe Met 
    1520                 1525                 1530             


Trp Asp  Cys Cys Cys Glu Ser  Val Lys Lys Xaa Lys  Lys Ser Pro 
    1535                 1540                 1545             


Gly Ser  Gly Cys Ile Leu Ala  His Cys Met Gly Leu  Gly Lys Xaa 
    1550                 1555                 1560             


Leu Gln  Val Val Ser Phe Leu  His Xaa Val Leu Leu  Cys Asp Lys 
    1565                 1570                 1575             


Leu Asp  Phe Ser Xaa Ala Leu  Val Val Cys Pro Leu  Asn Xaa Ala 
    1580                 1585                 1590             


Leu Asn  Trp Met Asn Glu Phe  Glu Lys Trp Gln Glu  Gly Leu Lys 
    1595                 1600                 1605             


Asp Asp  Glu Lys Leu Glu Val  Ser Glu Leu Ala Xaa  Val Lys Arg 
    1610                 1615                 1620             


Pro Gln  Glu Arg Ser Tyr Met  Leu Gln Arg Trp Gln  Glu Asp Gly 
    1625                 1630                 1635             


Gly Val  Met Ile Ile Gly Tyr  Glu Met Tyr Arg Asn  Leu Ala Gln 
    1640                 1645                 1650             


Gly Arg  Asn Val Lys Ser Arg  Lys Leu Lys Glu Ile  Phe Asn Lys 
    1655                 1660                 1665             


Ala Leu  Val Asp Pro Gly Pro  Asp Phe Val Val Cys  Asp Glu Gly 
    1670                 1675                 1680             


His Ile  Leu Lys Asn Glu Ala  Ser Ala Val Ser Lys  Ala Met Asn 
    1685                 1690                 1695             


Ser Ile  Arg Ser Arg Arg Arg  Ile Ile Leu Xaa Gly  Xaa Pro Leu 
    1700                 1705                 1710             


Gln Asn  Asn Leu Ile Glu Tyr  His Cys Met Val Asn  Phe Ile Lys 
    1715                 1720                 1725             


Glu Asn  Leu Leu Gly Ser Ile  Lys Glu Phe Arg Asn  Arg Phe Ile 
    1730                 1735                 1740             


Asn Pro  Ile Gln Asn Gly Gln  Cys Ala Asp Ser Xaa  Met Val Asp 
    1745                 1750                 1755             


Val Arg  Val Met Lys Lys Arg  Ala His Ile Leu Tyr  Glu Met Leu 
    1760                 1765                 1770             


Ala Gly  Cys Val Gln Arg Lys  Asp Tyr Xaa Ala Leu  Xaa Lys Phe 
    1775                 1780                 1785             


Leu Pro  Pro Lys His Glu Tyr  Val Leu Ala Val Arg  Met Xaa Ser 
    1790                 1795                 1800             


Ile Gln  Cys Lys Leu Tyr Gln  Tyr Tyr Leu Asp His  Leu Xaa Gly 
    1805                 1810                 1815             


Val Gly  Asn Asn Ser Glu Gly  Gly Arg Gly Lys Ala  Gly Ala Lys 
    1820                 1825                 1830             


Leu Phe  Gln Asp Phe Gln Met  Leu Ser Arg Ile Trp  Xaa His Pro 
    1835                 1840                 1845             


Trp Cys  Leu Gln Leu Asp Tyr  Ile Ser Lys Glu Asn  Lys Gly Tyr 
    1850                 1855                 1860             


Phe Asp  Glu Asp Ser Met Asp  Glu Phe Ile Ala Ser  Asp Ser Asp 
    1865                 1870                 1875             


Glu Xaa  Ser Met Ser Leu Ser  Ser Asp Asp Tyr Xaa  Lys Lys Lys 
    1880                 1885                 1890             


Lys Lys  Gly Lys Lys Gly Lys  Lys Asp Ser Ser Ser  Ser Gly Ser 
    1895                 1900                 1905             


Gly Ser  Asp Asn Asp Val Glu  Val Ile Lys Val Trp  Asn Ser Arg 
    1910                 1915                 1920             


Ser Arg  Gly Gly Gly Glu Gly  Asn Val Asp Glu Xaa  Gly Asn Asn 
    1925                 1930                 1935             


Pro Ser  Val Ser Leu Lys Leu  Glu Glu Ser Lys Ala  Xaa Ser Ser 
    1940                 1945                 1950             


Ser Asn  Pro Ser Ser Pro Ala  Pro Asp Trp Tyr Lys  Asp Phe Val 
    1955                 1960                 1965             


Xaa Asp  Ala Asp Ala Glu Val  Leu Glu His Ser Gly  Lys Met Val 
    1970                 1975                 1980             


Leu Leu  Phe Glu Ile Leu Arg  Met Ala Glu Glu Ile  Gly Asp Lys 
    1985                 1990                 1995             


Val Leu  Val Phe Ser Gln Ser  Leu Ile Ser Leu Asp  Leu Ile Glu 
    2000                 2005                 2010             


Asp Phe  Leu Glu Leu Ala Ser  Arg Glu Lys Xaa Glu  Asp Lys Asp 
    2015                 2020                 2025             


Lys Pro  Leu Ile Tyr Lys Gly  Glu Gly Lys Trp Leu  Arg Asn Ile 
    2030                 2035                 2040             


Asp Tyr  Tyr Arg Leu Asp Gly  Ser Xaa Xaa Ala Gln  Ser Arg Lys 
    2045                 2050                 2055             


Lys Trp  Ala Glu Glu Phe Asn  Asp Glu Xaa Asn Val  Arg Gly Arg 
    2060                 2065                 2070             


Leu Phe  Ile Ile Ser Xaa Lys  Ala Gly Ser Leu Gly  Ile Asn Leu 
    2075                 2080                 2085             


Val Ala  Ala Asn Arg Val Ile  Ile Phe Asp Ala Ser  Trp Asn Pro 
    2090                 2095                 2100             


Ser Tyr  Asp Ile Gln Ser Ile  Phe Arg Val Tyr Arg  Phe Gly Gln 
    2105                 2110                 2115             


Xaa Lys  Pro Val Tyr Val Tyr  Arg Phe Leu Ala Gln  Gly Xaa Met 
    2120                 2125                 2130             


Glu Asp  Lys Ile Tyr Asp Arg  Gln Val Xaa Lys Gln  Ser Leu Ser 
    2135                 2140                 2145             


Phe Arg  Val Val Asp Gln Gln  Gln Val Glu Arg His  Phe Xaa Met 
    2150                 2155                 2160             


Asn Glu  Leu Xaa Glu Leu Tyr  Xaa Phe Glu Pro Asp  Leu Leu Asp 
    2165                 2170                 2175             


Asp Pro  Asn Ser Glu Lys Lys  Lys Lys Arg Asp Xaa  Pro Met Leu 
    2180                 2185                 2190             


Pro Lys  Asp Xaa Ile Leu Ala  Glu Leu Leu Gln Ile  His Lys Glu 
    2195                 2200                 2205             


His Ile  Val Gly Tyr His Glu  His Asp Ser Leu Leu  Asp His Lys 
    2210                 2215                 2220             


Glu Glu  Glu Glu Leu Xaa Glu  Glu Glu Arg Lys Ala  Ala Trp Ala 
    2225                 2230                 2235             


Glu Tyr  Glu Ala Glu Lys Lys  Gly Leu Xaa Met Arg  Phe Asn Ile 
    2240                 2245                 2250             


Pro Xaa  Gly Xaa Asn Leu Pro  Pro Val Ser Phe Asn  Ser Gln Xaa 
    2255                 2260                 2265             


Pro Tyr  Ile Pro Phe Asn Leu  Gly Ala Leu Ser Ala  Met Ser Asn 
    2270                 2275                 2280             


Gln Gln  Leu Glu Asp Leu Ile  Asn Gln Gly Arg Glu  Lys Val Val 
    2285                 2290                 2295             


Glu Ala  Xaa Asn Ser Val Xaa  Ala Val Arg Ile Gln  Pro Leu Glu 
    2300                 2305                 2310             


Asp Ile  Ile Ser Ala Val Trp  Lys Glu Asn Met Asn  Leu Ser Glu 
    2315                 2320                 2325             


Ala Gln  Val Gln Ala Leu Ala  Leu Ser Arg Gln Ala  Ser Gln Glu 
    2330                 2335                 2340             


Leu Asp  Val Lys Arg Arg Glu  Ala Ile Tyr Asn Asp  Val Leu Xaa 
    2345                 2350                 2355             


Lys Gln  Gln Met Leu Ile Ser  Cys Val Gln Arg Ile  Leu Met Asn 
    2360                 2365                 2370             


Arg Arg  Leu Gln Gln Gln Tyr  Asn Gln Gln Gln Gln  Gln Gln Met 
    2375                 2380                 2385             


Xaa Tyr  Gln Gln Ala Xaa Leu  Gly His Leu Met Met  Pro Lys Pro 
    2390                 2395                 2400             


Pro Asn  Leu Ile Met Asn Pro  Ser Asn Tyr Gln Gln  Ile Asp Met 
    2405                 2410                 2415             


Arg Gly  Met Tyr Gln Pro Val  Ala Gly Gly Met Gln  Pro Pro Pro 
    2420                 2425                 2430             


Leu Gln  Arg Ala Pro Pro Pro  Met Arg Ser Lys Asn  Pro Gly Pro 
    2435                 2440                 2445             


Ser Gln  Gly Lys Ser Met 
    2450                 


<210> 3734
<211> 954
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<400> 3734
Met Xaa Ala Glu Pro Met Ser Glu Ser Lys Leu Asn Xaa Leu Val Gln 
1               5                   10                  15      


Lys Leu His Asp Phe Leu Ala His Ser Ser Glu Glu Ser Glu Glu Xaa 
            20                  25                  30          


Ser Ser Pro Pro Arg Leu Ala Met Asn Gln Asn Xaa Asp Lys Ile Ser 
        35                  40                  45              


Gly Ser Gly Ser Asn Ser Asp Met Met Glu Asn Ser Lys Glu Glu Gly 
    50                  55                  60                  


Xaa Ser Ser Ser Glu Lys Ser Lys Ser Ser Gly Ser Ser Arg Ser Lys 
65                  70                  75                  80  


Arg Lys Pro Ser Ile Val Xaa Lys Tyr Val Glu Ser Asp Asp Glu Lys 
                85                  90                  95      


Pro Leu Asp Asp Glu Xaa Val Asn Glu Asp Ala Ser Asn Glu Asn Ser 
            100                 105                 110         


Glu Asn Asp Ile Xaa Met Gln Ser Leu Pro Lys Gly Xaa Val Ile Val 
        115                 120                 125             


Gln Pro Glu Pro Val Leu Asn Glu Asp Lys Asp Asp Phe Lys Gly Pro 
    130                 135                 140                 


Glu Phe Arg Ser Arg Ser Lys Met Lys Xaa Glu Asn Leu Lys Lys Arg 
145                 150                 155                 160 


Gly Glu Asp Gly Leu His Gly Ile Val Ser Cys Xaa Ala Cys Gly Gln 
                165                 170                 175     


Gln Val Asn His Phe Gln Lys Asp Ser Ile Tyr Arg His Pro Ser Leu 
            180                 185                 190         


Gln Val Leu Ile Cys Lys Asn Cys Phe Lys Tyr Tyr Met Ser Asp Asp 
        195                 200                 205             


Ile Ser Arg Asp Ser Asp Gly Met Asp Glu Gln Cys Arg Trp Cys Ala 
    210                 215                 220                 


Glu Gly Gly Asn Leu Ile Cys Cys Asp Phe Cys His Asn Ala Phe Cys 
225                 230                 235                 240 


Lys Lys Cys Ile Leu Arg Asn Leu Gly Arg Lys Glu Leu Ser Xaa Ile 
                245                 250                 255     


Met Asp Glu Asn Asn Gln Trp Tyr Cys Tyr Ile Cys His Pro Glu Pro 
            260                 265                 270         


Leu Leu Asp Leu Val Xaa Ala Cys Asn Ser Val Phe Glu Asn Leu Glu 
        275                 280                 285             


Gln Leu Leu Gln Gln Asn Lys Lys Lys Ile Lys Val Asp Ser Glu Lys 
    290                 295                 300                 


Ser Asn Lys Val Tyr Glu His Xaa Ser Arg Phe Ser Pro Lys Lys Xaa 
305                 310                 315                 320 


Ser Ser Asn Cys Asn Gly Glu Glu Lys Lys Leu Asp Asp Ser Cys Ser 
                325                 330                 335     


Gly Ser Val Xaa Tyr Ser Tyr Ser Ala Leu Ile Val Pro Lys Glu Met 
            340                 345                 350         


Ile Lys Lys Ala Lys Lys Leu Ile Glu Xaa Xaa Ala Asn Met Asn Ser 
        355                 360                 365             


Ser Tyr Val Lys Phe Leu Lys Gln Ala Xaa Asp Asn Ser Glu Ile Ser 
    370                 375                 380                 


Ser Ala Xaa Lys Leu Arg Gln Leu Lys Ala Phe Lys Ser Val Leu Ala 
385                 390                 395                 400 


Asp Ile Lys Lys Ala His Leu Ala Leu Glu Glu Asp Leu Asn Ser Glu 
                405                 410                 415     


Phe Arg Ala Met Asp Ala Val Asn Lys Glu Lys Asn Xaa Lys Glu His 
            420                 425                 430         


Lys Val Ile Asp Ala Lys Phe Glu Xaa Lys Ala Arg Lys Gly Glu Lys 
        435                 440                 445             


Pro Cys Ala Leu Glu Lys Lys Asp Ile Ser Lys Ser Glu Ala Lys Leu 
    450                 455                 460                 


Ser Arg Lys Gln Val Asp Ser Glu His Met His Gln Asn Val Pro Xaa 
465                 470                 475                 480 


Glu Glu Gln Arg Xaa Asn Lys Ser Xaa Gly Gly Glu His Lys Lys Ser 
                485                 490                 495     


Asp Arg Lys Glu Glu Pro Gln Tyr Glu Pro Ala Asn Xaa Ser Glu Asp 
            500                 505                 510         


Leu Asp Met Asp Ile Val Ser Val Pro Ser Ser Val Pro Glu Asp Ile 
        515                 520                 525             


Phe Glu Asn Leu Glu Xaa Ala Met Glu Val Gln Ser Ser Val Asp His 
    530                 535                 540                 


Gln Gly Asp Gly Ser Ser Gly Xaa Glu Gln Glu Val Glu Ser Ser Ser 
545                 550                 555                 560 


Val Lys Leu Asn Ile Ser Ser Lys Asp Asn Arg Gly Gly Ala Asp Cys 
                565                 570                 575     


Gln Glu Val Pro Gln Asp Lys Asp Gly Tyr Lys Ser Cys Gly Leu Asn 
            580                 585                 590         


Pro Lys Leu Glu Lys Cys Gly Leu Gly Gln Glu Asn Ser Asp Asn Glu 
        595                 600                 605             


His Leu Val Glu Asn Glu Val Ser Leu Leu Leu Glu Glu Ser Asp Leu 
    610                 615                 620                 


Arg Arg Ser Pro Arg Val Lys Xaa Xaa Pro Leu Arg Arg Pro Xaa Glu 
625                 630                 635                 640 


Xaa Asn Pro Val Xaa Ser Asn Ser Asp Glu Glu Cys Asn Glu Xaa Val 
                645                 650                 655     


Lys Glu Lys Gln Lys Leu Ser Val Pro Val Arg Lys Lys Asp Lys Arg 
            660                 665                 670         


Asn Ser Ser Asp Ser Ala Ile Asp Asn Pro Lys Pro Asn Lys Leu Pro 
        675                 680                 685             


Lys Ser Lys Gln Ser Glu Xaa Val Asp Gln Asn Ser Asp Ser Asp Glu 
    690                 695                 700                 


Met Leu Ala Ile Leu Lys Glu Val Ser Arg Met Ser His Ser Ser Ser 
705                 710                 715                 720 


Ser Asp Xaa Asp Ile Asn Glu Ile His Xaa Asn His Lys Xaa Leu Tyr 
                725                 730                 735     


Asp Leu Lys Xaa Gln Ala Gly Lys Asp Asp Lys Gly Lys Arg Lys Arg 
            740                 745                 750         


Lys Ser Ser Xaa Ser Gly Ser Asp Phe Asp Xaa Lys Lys Gly Lys Ser 
        755                 760                 765             


Ala Lys Ser Ser Ile Ile Ser Lys Lys Lys Arg Gln Xaa Gln Ser Glu 
    770                 775                 780                 


Ser Ser Asn Tyr Asp Ser Glu Leu Glu Lys Glu Ile Lys Ser Met Ser 
785                 790                 795                 800 


Lys Ile Gly Ala Ala Arg Xaa Xaa Lys Lys Arg Ile Pro Asn Xaa Lys 
                805                 810                 815     


Asp Phe Asp Ser Ser Glu Asp Glu Lys His Ser Lys Lys Gly Met Asp 
            820                 825                 830         


Asn Gln Gly His Lys Asn Leu Lys Xaa Ser Gln Glu Gly Ser Ser Asp 
        835                 840                 845             


Asp Ala Glu Arg Lys Gln Glu Arg Glu Xaa Phe Ser Ser Ala Glu Gly 
    850                 855                 860                 


Xaa Val Asp Lys Asp Xaa Xaa Ile Met Glu Leu Arg Asp Arg Leu Pro 
865                 870                 875                 880 


Lys Lys Gln Gln Ala Ser Ala Ser Xaa Asp Gly Val Asp Lys Leu Ser 
                885                 890                 895     


Gly Lys Glu Glu Ser Phe Xaa Ser Leu Glu Val Arg Lys Val Ala Glu 
            900                 905                 910         


Xaa Lys Glu Lys Ser Lys His Leu Lys Xaa Lys Xaa Cys Lys Lys Val 
        915                 920                 925             


Gln Asp Gly Leu Ser Asp Ile Ala Glu Lys Phe Leu Lys Lys Asp Gln 
    930                 935                 940                 


Ser Asp Glu Xaa Ser Glu Asp Asp Lys Lys 
945                 950                 


<210> 3735
<211> 2492
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1191)..(1191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1193)..(1193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1346)..(1346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1491)..(1491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1493)..(1493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1529)..(1529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1534)..(1535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1601)..(1601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1610)..(1610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1630)..(1630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1658)..(1658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1747)..(1747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1749)..(1749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1793)..(1793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1821)..(1821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1824)..(1824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1840)..(1840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1855)..(1855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1884)..(1884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1918)..(1918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1928)..(1928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1973)..(1973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1989)..(1989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2007)..(2007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2062)..(2062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2090)..(2091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2106)..(2106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2117)..(2117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2157)..(2157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2170)..(2170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2181)..(2181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2200)..(2200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2205)..(2205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2209)..(2209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2228)..(2228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2235)..(2235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2267)..(2267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2286)..(2286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2293)..(2293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2295)..(2295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2306)..(2306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2339)..(2339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2343)..(2343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2396)..(2396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2427)..(2427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2432)..(2432)
<223> Selenocysteine

<400> 3735
Met Xaa Ala Glu Pro Met Ser Glu Ser Lys Leu Asn Xaa Leu Val Gln 
1               5                   10                  15      


Lys Leu His Asp Phe Leu Ala His Ser Ser Glu Glu Ser Glu Glu Xaa 
            20                  25                  30          


Ser Ser Pro Pro Arg Leu Ala Met Asn Gln Asn Xaa Asp Lys Ile Ser 
        35                  40                  45              


Gly Ser Gly Ser Asn Ser Asp Met Met Glu Asn Ser Lys Glu Glu Gly 
    50                  55                  60                  


Xaa Ser Ser Ser Glu Lys Ser Lys Ser Ser Gly Ser Ser Arg Ser Lys 
65                  70                  75                  80  


Arg Lys Pro Ser Ile Val Xaa Lys Tyr Val Glu Ser Asp Asp Glu Lys 
                85                  90                  95      


Pro Leu Asp Asp Glu Xaa Val Asn Glu Asp Ala Ser Asn Glu Asn Ser 
            100                 105                 110         


Glu Asn Asp Ile Xaa Met Gln Ser Leu Pro Lys Gly Xaa Val Ile Val 
        115                 120                 125             


Gln Pro Glu Pro Val Leu Asn Glu Asp Lys Asp Asp Phe Lys Gly Pro 
    130                 135                 140                 


Glu Phe Arg Ser Arg Ser Lys Met Lys Xaa Glu Asn Leu Lys Lys Arg 
145                 150                 155                 160 


Gly Glu Asp Gly Leu His Gly Ile Val Ser Cys Xaa Ala Cys Gly Gln 
                165                 170                 175     


Gln Val Asn His Phe Gln Lys Asp Ser Ile Tyr Arg His Pro Ser Leu 
            180                 185                 190         


Gln Val Leu Ile Cys Lys Asn Cys Phe Lys Tyr Tyr Met Ser Asp Asp 
        195                 200                 205             


Ile Ser Arg Asp Ser Asp Gly Met Asp Glu Gln Cys Arg Trp Cys Ala 
    210                 215                 220                 


Glu Gly Gly Asn Leu Ile Cys Cys Asp Phe Cys His Asn Ala Phe Cys 
225                 230                 235                 240 


Lys Lys Cys Ile Leu Arg Asn Leu Gly Arg Lys Glu Leu Ser Xaa Ile 
                245                 250                 255     


Met Asp Glu Asn Asn Gln Trp Tyr Cys Tyr Ile Cys His Pro Glu Pro 
            260                 265                 270         


Leu Leu Asp Leu Val Xaa Ala Cys Asn Ser Val Phe Glu Asn Leu Glu 
        275                 280                 285             


Gln Leu Leu Gln Gln Asn Lys Lys Lys Ile Lys Val Asp Ser Glu Lys 
    290                 295                 300                 


Ser Asn Lys Val Tyr Glu His Xaa Ser Arg Phe Ser Pro Lys Lys Xaa 
305                 310                 315                 320 


Ser Ser Asn Cys Asn Gly Glu Glu Lys Lys Leu Asp Asp Ser Cys Ser 
                325                 330                 335     


Gly Ser Val Xaa Tyr Ser Tyr Ser Ala Leu Ile Val Pro Lys Glu Met 
            340                 345                 350         


Ile Lys Lys Ala Lys Lys Leu Ile Glu Xaa Xaa Ala Asn Met Asn Ser 
        355                 360                 365             


Ser Tyr Val Lys Phe Leu Lys Gln Ala Xaa Asp Asn Ser Glu Ile Ser 
    370                 375                 380                 


Ser Ala Xaa Lys Leu Arg Gln Leu Lys Ala Phe Lys Ser Val Leu Ala 
385                 390                 395                 400 


Asp Ile Lys Lys Ala His Leu Ala Leu Glu Glu Asp Leu Asn Ser Glu 
                405                 410                 415     


Phe Arg Ala Met Asp Ala Val Asn Lys Glu Lys Asn Xaa Lys Glu His 
            420                 425                 430         


Lys Val Ile Asp Ala Lys Phe Glu Xaa Lys Ala Arg Lys Gly Glu Lys 
        435                 440                 445             


Pro Cys Ala Leu Glu Lys Lys Asp Ile Ser Lys Ser Glu Ala Lys Leu 
    450                 455                 460                 


Ser Arg Lys Gln Val Asp Ser Glu His Met His Gln Asn Val Pro Xaa 
465                 470                 475                 480 


Glu Glu Gln Arg Xaa Asn Lys Ser Xaa Gly Gly Glu His Lys Lys Ser 
                485                 490                 495     


Asp Arg Lys Glu Glu Pro Gln Tyr Glu Pro Ala Asn Xaa Ser Glu Asp 
            500                 505                 510         


Leu Asp Met Asp Ile Val Ser Val Pro Ser Ser Val Pro Glu Asp Ile 
        515                 520                 525             


Phe Glu Asn Leu Glu Xaa Ala Met Glu Val Gln Ser Ser Val Asp His 
    530                 535                 540                 


Gln Gly Asp Gly Ser Ser Gly Xaa Glu Gln Glu Val Glu Ser Ser Ser 
545                 550                 555                 560 


Val Lys Leu Asn Ile Ser Ser Lys Asp Asn Arg Gly Gly Ile Lys Ser 
                565                 570                 575     


Lys Xaa Xaa Ala Lys Val Xaa Lys Glu Leu Tyr Val Lys Leu Xaa Pro 
            580                 585                 590         


Val Ser Leu Ser Asn Ser Pro Ile Lys Gly Ala Asp Cys Gln Glu Val 
        595                 600                 605             


Pro Gln Asp Lys Asp Gly Tyr Lys Ser Cys Gly Leu Asn Pro Lys Leu 
    610                 615                 620                 


Glu Lys Cys Gly Leu Gly Gln Glu Asn Ser Asp Asn Glu His Leu Val 
625                 630                 635                 640 


Glu Asn Glu Val Ser Leu Leu Leu Glu Glu Ser Asp Leu Arg Arg Ser 
                645                 650                 655     


Pro Arg Val Lys Xaa Xaa Pro Leu Arg Arg Pro Xaa Glu Xaa Asn Pro 
            660                 665                 670         


Val Xaa Ser Asn Ser Asp Glu Glu Cys Asn Glu Xaa Val Lys Glu Lys 
        675                 680                 685             


Gln Lys Leu Ser Val Pro Val Arg Lys Lys Asp Lys Arg Asn Ser Ser 
    690                 695                 700                 


Asp Ser Ala Ile Asp Asn Pro Lys Pro Asn Lys Leu Pro Lys Ser Lys 
705                 710                 715                 720 


Gln Ser Glu Xaa Val Asp Gln Asn Ser Asp Ser Asp Glu Met Leu Ala 
                725                 730                 735     


Ile Leu Lys Glu Val Ser Arg Met Ser His Ser Ser Ser Ser Asp Xaa 
            740                 745                 750         


Asp Ile Asn Glu Ile His Xaa Asn His Lys Xaa Leu Tyr Asp Leu Lys 
        755                 760                 765             


Xaa Gln Ala Gly Lys Asp Asp Lys Gly Lys Arg Lys Arg Lys Ser Ser 
    770                 775                 780                 


Xaa Ser Gly Ser Asp Phe Asp Xaa Lys Lys Gly Lys Ser Ala Lys Ser 
785                 790                 795                 800 


Ser Ile Ile Ser Lys Lys Lys Arg Gln Xaa Gln Ser Glu Ser Ser Asn 
                805                 810                 815     


Tyr Asp Ser Glu Leu Glu Lys Glu Ile Lys Ser Met Ser Lys Ile Gly 
            820                 825                 830         


Ala Ala Arg Xaa Xaa Lys Lys Arg Ile Pro Asn Xaa Lys Asp Phe Asp 
        835                 840                 845             


Ser Ser Glu Asp Glu Lys His Ser Lys Lys Gly Met Asp Asn Gln Gly 
    850                 855                 860                 


His Lys Asn Leu Lys Xaa Ser Gln Glu Gly Ser Ser Asp Asp Ala Glu 
865                 870                 875                 880 


Arg Lys Gln Glu Arg Glu Xaa Phe Ser Ser Ala Glu Gly Xaa Val Asp 
                885                 890                 895     


Lys Asp Xaa Xaa Ile Met Glu Leu Arg Asp Arg Leu Pro Lys Lys Gln 
            900                 905                 910         


Gln Ala Ser Ala Ser Xaa Asp Gly Val Asp Lys Leu Ser Gly Lys Glu 
        915                 920                 925             


Glu Ser Phe Xaa Ser Leu Glu Val Arg Lys Val Ala Glu Xaa Lys Glu 
    930                 935                 940                 


Lys Ser Lys His Leu Lys Xaa Lys Xaa Cys Lys Lys Val Gln Asp Gly 
945                 950                 955                 960 


Leu Ser Asp Ile Ala Glu Lys Phe Leu Lys Lys Asp Gln Ser Asp Glu 
                965                 970                 975     


Xaa Ser Glu Asp Asp Lys Lys Gln Ser Lys Lys Gly Xaa Glu Glu Lys 
            980                 985                 990         


Lys Lys Pro Ser Asp Phe Lys Lys  Lys Val Ile Lys Met  Glu Gln Gln 
        995                 1000                 1005             


Tyr Glu  Ser Ser Ser Asp Gly  Xaa Glu Lys Leu Pro  Glu Arg Glu 
    1010                 1015                 1020             


Glu Ile  Cys His Phe Pro Lys  Gly Ile Lys Gln Ile  Lys Asn Gly 
    1025                 1030                 1035             


Xaa Xaa  Asp Gly Glu Lys Lys  Ser Lys Lys Ile Arg  Asp Lys Xaa 
    1040                 1045                 1050             


Ser Lys  Lys Lys Asp Glu Leu  Ser Asp Tyr Ala Glu  Lys Ser Xaa 
    1055                 1060                 1065             


Gly Lys  Gly Asp Ser Cys Asp  Ser Ser Glu Asp Lys  Lys Ser Lys 
    1070                 1075                 1080             


Asn Gly  Ala Tyr Gly Arg Glu  Lys Lys Arg Cys Lys  Leu Leu Gly 
    1085                 1090                 1095             


Lys Ser  Ser Arg Lys Arg Gln  Asp Cys Ser Ser Ser  Asp Xaa Glu 
    1100                 1105                 1110             


Lys Tyr  Ser Met Lys Glu Asp  Gly Cys Asn Ser Ser  Asp Lys Arg 
    1115                 1120                 1125             


Leu Lys  Arg Ile Glu Leu Arg  Glu Arg Arg Asn Leu  Ser Ser Lys 
    1130                 1135                 1140             


Arg Asn  Xaa Lys Glu Ile Gln  Ser Gly Ser Ser Ser  Ser Asp Ala 
    1145                 1150                 1155             


Glu Glu  Ser Ser Glu Asp Asn  Lys Lys Lys Lys Gln  Arg Xaa Ser 
    1160                 1165                 1170             


Ser Lys  Lys Lys Ala Val Ile  Val Lys Glu Lys Lys  Arg Asn Ser 
    1175                 1180                 1185             


Leu Arg  Xaa Ser Xaa Lys Arg  Lys Gln Ala Asp Ile  Xaa Ser Ser 
    1190                 1195                 1200             


Ser Ser  Ser Asp Ile Glu Asp  Asp Asp Gln Asn Ser  Ile Gly Glu 
    1205                 1210                 1215             


Gly Ser  Ser Asp Glu Gln Lys  Ile Lys Pro Val Xaa  Glu Asn Leu 
    1220                 1225                 1230             


Val Leu  Ser Ser His Xaa Gly  Phe Cys Gln Ser Ser  Gly Asp Glu 
    1235                 1240                 1245             


Ala Leu  Ser Lys Ser Val Pro  Val Xaa Val Asp Asp  Asp Asp Asp 
    1250                 1255                 1260             


Asp Asn  Asp Pro Glu Asn Arg  Ile Ala Lys Lys Met  Leu Leu Glu 
    1265                 1270                 1275             


Glu Ile  Lys Ala Asn Leu Ser  Ser Asp Glu Asp Gly  Ser Ser Asp 
    1280                 1285                 1290             


Asp Glu  Pro Glu Glu Gly Lys  Lys Arg Xaa Gly Lys  Gln Asn Glu 
    1295                 1300                 1305             


Glu Asn  Pro Gly Asp Glu Glu  Ala Lys Asn Gln Val  Asn Ser Glu 
    1310                 1315                 1320             


Ser Asp  Ser Asp Ser Glu Glu  Ser Lys Lys Pro Arg  Tyr Arg His 
    1325                 1330                 1335             


Arg Leu  Leu Arg His Lys Leu  Xaa Val Ser Asp Gly  Glu Ser Gly 
    1340                 1345                 1350             


Glu Glu  Lys Lys Xaa Lys Pro  Lys Glu His Lys Glu  Val Lys Gly 
    1355                 1360                 1365             


Arg Asn  Arg Arg Lys Val Ser  Ser Glu Asp Ser Glu  Asp Ser Asp 
    1370                 1375                 1380             


Phe Gln  Glu Ser Gly Val Ser  Glu Glu Val Ser Glu  Ser Glu Asp 
    1385                 1390                 1395             


Glu Gln  Arg Pro Arg Xaa Arg  Ser Ala Lys Lys Ala  Glu Leu Glu 
    1400                 1405                 1410             


Glu Asn  Gln Arg Ser Tyr Lys  Gln Lys Lys Lys Arg  Arg Arg Ile 
    1415                 1420                 1425             


Lys Val  Gln Glu Asp Ser Ser  Ser Glu Asn Lys Ser  Asn Ser Glu 
    1430                 1435                 1440             


Glu Glu  Glu Glu Glu Lys Glu  Glu Glu Glu Glu Glu  Glu Glu Glu 
    1445                 1450                 1455             


Glu Glu  Glu Glu Glu Glu Asp  Glu Asn Asp Asp Ser  Lys Ser Pro 
    1460                 1465                 1470             


Gly Lys  Gly Arg Lys Lys Ile  Arg Lys Ile Leu Lys  Asp Asp Lys 
    1475                 1480                 1485             


Leu Arg  Xaa Glu Xaa Gln Asn  Ala Leu Lys Glu Glu  Glu Glu Arg 
    1490                 1495                 1500             


Arg Lys  Arg Ile Ala Glu Arg  Glu Arg Glu Arg Glu  Lys Leu Arg 
    1505                 1510                 1515             


Glu Val  Ile Glu Ile Glu Asp  Ala Ser Pro Xaa Lys  Cys Pro Ile 
    1520                 1525                 1530             


Xaa Xaa  Lys Leu Val Leu Asp  Glu Asp Glu Glu Xaa  Lys Glu Pro 
    1535                 1540                 1545             


Leu Val  Gln Val His Arg Asn  Met Val Ile Lys Leu  Lys Pro His 
    1550                 1555                 1560             


Gln Val  Asp Gly Val Gln Phe  Met Trp Asp Cys Cys  Cys Glu Ser 
    1565                 1570                 1575             


Val Lys  Lys Xaa Lys Lys Ser  Pro Gly Ser Gly Cys  Ile Leu Ala 
    1580                 1585                 1590             


His Cys  Met Gly Leu Gly Lys  Xaa Leu Gln Val Val  Ser Phe Leu 
    1595                 1600                 1605             


His Xaa  Val Leu Leu Cys Asp  Lys Leu Asp Phe Ser  Xaa Ala Leu 
    1610                 1615                 1620             


Val Val  Cys Pro Leu Asn Xaa  Ala Leu Asn Trp Met  Asn Glu Phe 
    1625                 1630                 1635             


Glu Lys  Trp Gln Glu Gly Leu  Lys Asp Asp Glu Lys  Leu Glu Val 
    1640                 1645                 1650             


Ser Glu  Leu Ala Xaa Val Lys  Arg Pro Gln Glu Arg  Ser Tyr Met 
    1655                 1660                 1665             


Leu Gln  Arg Trp Gln Glu Asp  Gly Gly Val Met Ile  Ile Gly Tyr 
    1670                 1675                 1680             


Glu Met  Tyr Arg Asn Leu Ala  Gln Gly Arg Asn Val  Lys Ser Arg 
    1685                 1690                 1695             


Lys Leu  Lys Glu Ile Phe Asn  Lys Ala Leu Val Asp  Pro Gly Pro 
    1700                 1705                 1710             


Asp Phe  Val Val Cys Asp Glu  Gly His Ile Leu Lys  Asn Glu Ala 
    1715                 1720                 1725             


Ser Ala  Val Ser Lys Ala Met  Asn Ser Ile Arg Ser  Arg Arg Arg 
    1730                 1735                 1740             


Ile Ile  Leu Xaa Gly Xaa Pro  Leu Gln Asn Asn Leu  Ile Glu Tyr 
    1745                 1750                 1755             


His Cys  Met Val Asn Phe Ile  Lys Glu Asn Leu Leu  Gly Ser Ile 
    1760                 1765                 1770             


Lys Glu  Phe Arg Asn Arg Phe  Ile Asn Pro Ile Gln  Asn Gly Gln 
    1775                 1780                 1785             


Cys Ala  Asp Ser Xaa Met Val  Asp Val Arg Val Met  Lys Lys Arg 
    1790                 1795                 1800             


Ala His  Ile Leu Tyr Glu Met  Leu Ala Gly Cys Val  Gln Arg Lys 
    1805                 1810                 1815             


Asp Tyr  Xaa Ala Leu Xaa Lys  Phe Leu Pro Pro Lys  His Glu Tyr 
    1820                 1825                 1830             


Val Leu  Ala Val Arg Met Xaa  Ser Ile Gln Cys Lys  Leu Tyr Gln 
    1835                 1840                 1845             


Tyr Tyr  Leu Asp His Leu Xaa  Gly Val Gly Asn Asn  Ser Glu Gly 
    1850                 1855                 1860             


Gly Arg  Gly Lys Ala Gly Ala  Lys Leu Phe Gln Asp  Phe Gln Met 
    1865                 1870                 1875             


Leu Ser  Arg Ile Trp Xaa His  Pro Trp Cys Leu Gln  Leu Asp Tyr 
    1880                 1885                 1890             


Ile Ser  Lys Glu Asn Lys Gly  Tyr Phe Asp Glu Asp  Ser Met Asp 
    1895                 1900                 1905             


Glu Phe  Ile Ala Ser Asp Ser  Asp Glu Xaa Ser Met  Ser Leu Ser 
    1910                 1915                 1920             


Ser Asp  Asp Tyr Xaa Lys Lys  Lys Lys Lys Gly Lys  Lys Gly Lys 
    1925                 1930                 1935             


Lys Asp  Ser Ser Ser Ser Gly  Ser Gly Ser Asp Asn  Asp Val Glu 
    1940                 1945                 1950             


Val Ile  Lys Val Trp Asn Ser  Arg Ser Arg Gly Gly  Gly Glu Gly 
    1955                 1960                 1965             


Asn Val  Asp Glu Xaa Gly Asn  Asn Pro Ser Val Ser  Leu Lys Leu 
    1970                 1975                 1980             


Glu Glu  Ser Lys Ala Xaa Ser  Ser Ser Asn Pro Ser  Ser Pro Ala 
    1985                 1990                 1995             


Pro Asp  Trp Tyr Lys Asp Phe  Val Xaa Asp Ala Asp  Ala Glu Val 
    2000                 2005                 2010             


Leu Glu  His Ser Gly Lys Met  Val Leu Leu Phe Glu  Ile Leu Arg 
    2015                 2020                 2025             


Met Ala  Glu Glu Ile Gly Asp  Lys Val Leu Val Phe  Ser Gln Ser 
    2030                 2035                 2040             


Leu Ile  Ser Leu Asp Leu Ile  Glu Asp Phe Leu Glu  Leu Ala Ser 
    2045                 2050                 2055             


Arg Glu  Lys Xaa Glu Asp Lys  Asp Lys Pro Leu Ile  Tyr Lys Gly 
    2060                 2065                 2070             


Glu Gly  Lys Trp Leu Arg Asn  Ile Asp Tyr Tyr Arg  Leu Asp Gly 
    2075                 2080                 2085             


Ser Xaa  Xaa Ala Gln Ser Arg  Lys Lys Trp Ala Glu  Glu Phe Asn 
    2090                 2095                 2100             


Asp Glu  Xaa Asn Val Arg Gly  Arg Leu Phe Ile Ile  Ser Xaa Lys 
    2105                 2110                 2115             


Ala Gly  Ser Leu Gly Ile Asn  Leu Val Ala Ala Asn  Arg Val Ile 
    2120                 2125                 2130             


Ile Phe  Asp Ala Ser Trp Asn  Pro Ser Tyr Asp Ile  Gln Ser Ile 
    2135                 2140                 2145             


Phe Arg  Val Tyr Arg Phe Gly  Gln Xaa Lys Pro Val  Tyr Val Tyr 
    2150                 2155                 2160             


Arg Phe  Leu Ala Gln Gly Xaa  Met Glu Asp Lys Ile  Tyr Asp Arg 
    2165                 2170                 2175             


Gln Val  Xaa Lys Gln Ser Leu  Ser Phe Arg Val Val  Asp Gln Gln 
    2180                 2185                 2190             


Gln Val  Glu Arg His Phe Xaa  Met Asn Glu Leu Xaa  Glu Leu Tyr 
    2195                 2200                 2205             


Xaa Phe  Glu Pro Asp Leu Leu  Asp Asp Pro Asn Ser  Glu Lys Lys 
    2210                 2215                 2220             


Lys Lys  Arg Asp Xaa Pro Met  Leu Pro Lys Asp Xaa  Ile Leu Ala 
    2225                 2230                 2235             


Glu Leu  Leu Gln Ile His Lys  Glu His Ile Val Gly  Tyr His Glu 
    2240                 2245                 2250             


His Asp  Ser Leu Leu Asp His  Lys Glu Glu Glu Glu  Leu Xaa Glu 
    2255                 2260                 2265             


Glu Glu  Arg Lys Ala Ala Trp  Ala Glu Tyr Glu Ala  Glu Lys Lys 
    2270                 2275                 2280             


Gly Leu  Xaa Met Arg Phe Asn  Ile Pro Xaa Gly Xaa  Asn Leu Pro 
    2285                 2290                 2295             


Pro Val  Ser Phe Asn Ser Gln  Xaa Pro Tyr Ile Pro  Phe Asn Leu 
    2300                 2305                 2310             


Gly Ala  Leu Ser Ala Met Ser  Asn Gln Gln Leu Glu  Asp Leu Ile 
    2315                 2320                 2325             


Asn Gln  Gly Arg Glu Lys Val  Val Glu Ala Xaa Asn  Ser Val Xaa 
    2330                 2335                 2340             


Ala Val  Arg Ile Gln Pro Leu  Glu Asp Ile Ile Ser  Ala Val Trp 
    2345                 2350                 2355             


Lys Glu  Asn Met Asn Leu Ser  Glu Ala Gln Val Gln  Ala Leu Ala 
    2360                 2365                 2370             


Leu Ser  Arg Gln Ala Ser Gln  Glu Leu Asp Val Lys  Arg Arg Glu 
    2375                 2380                 2385             


Ala Ile  Tyr Asn Asp Val Leu  Xaa Lys Gln Gln Met  Leu Ile Ser 
    2390                 2395                 2400             


Cys Val  Gln Arg Ile Leu Met  Asn Arg Arg Leu Gln  Gln Gln Tyr 
    2405                 2410                 2415             


Asn Gln  Gln Gln Gln Gln Gln  Met Xaa Tyr Gln Gln  Ala Xaa Leu 
    2420                 2425                 2430             


Gly His  Leu Met Met Pro Lys  Pro Pro Asn Leu Ile  Met Asn Pro 
    2435                 2440                 2445             


Ser Asn  Tyr Gln Gln Ile Asp  Met Arg Gly Met Tyr  Gln Pro Val 
    2450                 2455                 2460             


Ala Gly  Gly Met Gln Pro Pro  Pro Leu Gln Arg Ala  Pro Pro Pro 
    2465                 2470                 2475             


Met Arg  Ser Lys Asn Pro Gly  Pro Ser Gln Gly Lys  Ser Met 
    2480                 2485                 2490         


<210> 3736
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<400> 3736
Met Xaa Ala Glu Pro Met Ser Glu Ser Lys Leu Asn Xaa Leu Val Gln 
1               5                   10                  15      


Lys Leu His Asp Phe Leu Ala His Ser Ser Glu Glu Ser Glu Glu Xaa 
            20                  25                  30          


Ser Ser Pro Pro Arg Leu Ala Met Asn Gln Asn Xaa Asp Lys Ile Ser 
        35                  40                  45              


Gly Ser Gly Ser Asn Ser Asp Met Met Glu Asn Ser Lys Glu Glu Gly 
    50                  55                  60                  


Xaa Ser Ser Ser Glu Lys Ser Lys Ser Ser Gly Ser Ser Arg Ser Lys 
65                  70                  75                  80  


Arg Lys Pro Ser Ile Val Xaa Lys Tyr Val Glu Ser Asp Asp Glu Lys 
                85                  90                  95      


Pro Leu Asp Asp Glu Xaa Val Asn Glu Asp Ala Ser Asn Glu Asn Ser 
            100                 105                 110         


Glu Asn Asp Ile Xaa Met Gln Ser Leu Pro Lys Gly Xaa Val Ile Val 
        115                 120                 125             


Gln Pro Glu Pro Val Leu Asn Glu Asp Lys Asp Asp Phe Lys Gly Pro 
    130                 135                 140                 


Glu Phe Arg Ser Arg Ser Lys Met Lys Xaa Glu Asn Leu Lys Lys Arg 
145                 150                 155                 160 


Gly Val Leu Trp 
                


<210> 3737
<211> 293
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<400> 3737
Xaa Xaa Asp Gly Glu Lys Lys Ser Lys Lys Ile Arg Asp Lys Xaa Ser 
1               5                   10                  15      


Lys Lys Lys Asp Glu Leu Ser Asp Tyr Ala Glu Lys Ser Xaa Gly Lys 
            20                  25                  30          


Gly Asp Ser Cys Asp Ser Ser Glu Asp Lys Lys Ser Lys Asn Gly Ala 
        35                  40                  45              


Tyr Gly Arg Glu Lys Lys Arg Cys Lys Leu Leu Gly Lys Ser Ser Arg 
    50                  55                  60                  


Lys Arg Gln Asp Cys Ser Ser Ser Asp Xaa Glu Lys Tyr Ser Met Lys 
65                  70                  75                  80  


Glu Asp Gly Cys Asn Ser Ser Asp Lys Arg Leu Lys Arg Ile Glu Leu 
                85                  90                  95      


Arg Glu Arg Arg Asn Leu Ser Ser Lys Arg Asn Xaa Lys Glu Ile Gln 
            100                 105                 110         


Ser Gly Ser Ser Ser Ser Asp Ala Glu Glu Ser Ser Glu Asp Asn Lys 
        115                 120                 125             


Lys Lys Lys Gln Arg Xaa Ser Ser Lys Lys Lys Ala Val Ile Val Lys 
    130                 135                 140                 


Glu Lys Lys Arg Asn Ser Leu Arg Xaa Ser Xaa Lys Arg Lys Gln Ala 
145                 150                 155                 160 


Asp Ile Xaa Ser Ser Ser Ser Ser Asp Ile Glu Asp Asp Asp Gln Asn 
                165                 170                 175     


Ser Ile Gly Glu Gly Ser Ser Asp Glu Gln Lys Ile Lys Pro Val Xaa 
            180                 185                 190         


Glu Asn Leu Val Leu Ser Ser His Xaa Gly Phe Cys Gln Ser Ser Gly 
        195                 200                 205             


Asp Glu Ala Leu Ser Lys Ser Val Pro Val Xaa Val Asp Asp Asp Asp 
    210                 215                 220                 


Asp Asp Asn Asp Pro Glu Asn Arg Tyr Asp Ser Ile Cys Lys Asp Phe 
225                 230                 235                 240 


Lys Lys Ile Ile Xaa His Pro Arg His Gly His Lys Gln Gln Gln Arg 
                245                 250                 255     


Asn Ser Lys Gln Val Val Lys Xaa Arg Ser Ala Cys Leu Arg Lys Xaa 
            260                 265                 270         


Arg Ser Gln Ser Ser Cys Lys Phe Glu Arg Lys Ala Arg Lys Trp Ala 
        275                 280                 285             


Lys Xaa Gln Lys Pro 
    290             


<210> 3738
<211> 198
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<400> 3738
Xaa Glu Glu Gly Xaa Ser Ser Ser Glu Lys Ser Lys Ser Ser Gly Ser 
1               5                   10                  15      


Ser Arg Ser Lys Arg Lys Pro Ser Ile Val Xaa Lys Tyr Val Glu Ser 
            20                  25                  30          


Asp Asp Glu Lys Pro Leu Asp Asp Glu Xaa Val Asn Glu Asp Ala Ser 
        35                  40                  45              


Asn Glu Asn Ser Glu Asn Asp Ile Xaa Met Gln Ser Leu Pro Lys Gly 
    50                  55                  60                  


Xaa Val Ile Val Gln Pro Glu Pro Val Leu Asn Glu Asp Lys Asp Asp 
65                  70                  75                  80  


Phe Lys Gly Pro Glu Phe Arg Ser Arg Ser Lys Met Lys Xaa Glu Asn 
                85                  90                  95      


Leu Lys Lys Arg Gly Asp Gly Leu His Gly Ile Val Ser Cys Xaa Ala 
            100                 105                 110         


Cys Gly Gln Gln Val Asn His Phe Gln Lys Asp Ser Ile Tyr Arg His 
        115                 120                 125             


Pro Ser Leu Gln Val Leu Ile Cys Lys Asn Cys Phe Lys Tyr Tyr Met 
    130                 135                 140                 


Ser Asp Asp Ile Ser Arg Asp Ser Asp Gly Met Asp Glu Gln Cys Arg 
145                 150                 155                 160 


Trp Cys Ala Glu Gly Gly Asn Leu Ile Cys Cys Asp Phe Cys His Asn 
                165                 170                 175     


Ala Phe Cys Lys Lys Cys Ile Leu Arg Asn Leu Gly Arg Lys Glu Leu 
            180                 185                 190         


Ser Xaa Ile Met Asp Glu 
        195             


<210> 3739
<211> 66
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<400> 3739
Xaa Glu Asn Asp Asp Ser Lys Ser Pro Gly Lys Gly Arg Lys Lys Ile 
1               5                   10                  15      


Arg Lys Ile Leu Lys Asp Asp Lys Leu Arg Xaa Glu Xaa Gln Asn Ala 
            20                  25                  30          


Leu Lys Glu Glu Glu Glu Arg Arg Lys Arg Ile Ala Glu Arg Glu Arg 
        35                  40                  45              


Glu Arg Glu Lys Leu Arg Glu Val Xaa Asn Phe Phe Leu Leu Leu Phe 
    50                  55                  60                  


Leu Leu 
65      


<210> 3740
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<400> 3740
Xaa Arg Gly Lys Ala Gly Ala Lys Leu Phe Gln Asp Phe Gln Met Leu 
1               5                   10                  15      


Ser Arg Ile Trp Xaa His Pro Trp Cys Leu Gln Leu Asp Tyr Ile Ser 
            20                  25                  30          


Lys Glu Asn Lys Gly Tyr Phe Asp Glu Asp Ser Met Asp Glu Phe Ile 
        35                  40                  45              


Ala Ser Asp Ser Asp Glu Xaa Ser Met Ser Leu Ser Ser Asp Asp Tyr 
    50                  55                  60                  


Xaa Lys Lys Lys Lys Lys Gly Lys Lys Gly Lys Lys Asp Ser Ser Ser 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Asp Asn Asp Val Glu Val Ile Lys Val Trp Asn 
                85                  90                  95      


Ser Arg Ser Arg Gly Gly Gly Glu Gly Asn Val Asp Glu Xaa Gly Asn 
            100                 105                 110         


Asn Pro Ser Val Ser Leu Lys Leu Glu Glu Asn Ile Tyr Lys Val Leu 
        115                 120                 125             


Xaa Ile Cys Pro Asp Ile Arg Arg Glu Leu Ile Ser Leu Asn Gly Lys 
    130                 135                 140                 


Leu Lys Lys Val Lys Leu Leu Leu Leu Leu Ile Gln Ala Ala Gln Leu 
145                 150                 155                 160 


Gln Xaa Gly Xaa Lys Ile Leu Leu Gln Met Leu Met Leu Arg Phe 
                165                 170                 175 


<210> 3741
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<400> 3741
Asp Lys Leu Ile Gly Lys Lys Arg Lys Cys Ser Pro Ser Ser Ser Ser 
1               5                   10                  15      


Ile Asn Asn Ser Ser Ser Lys Pro Xaa Lys Val Ala Lys Val Pro Ala 
            20                  25                  30          


Val Asn Asn Val His Met Lys His Xaa Gly Xaa Ile Pro Gly Ala Gln 
        35                  40                  45              


Gly Leu Met Asn Ser Ser Leu Leu His Gln Asp Ile Ser Ser Pro Cys 
    50                  55                  60                  


Leu Arg Xaa Gly Ile Ser Ala Xaa Ser Pro Gln Ser Pro Asp Leu Lys 
65                  70                  75                  80  


Ser Lys Gly Xaa Ser Leu Xaa Ala Glu Asn Ser Xaa Gly Arg Asn Asn 
                85                  90                  95      


Ala Asp Xaa Phe Glu Asp Lys Leu His Leu His Ser Ala Leu Trp Xaa 
            100                 105                 110         


Pro Arg Cys 
        115 


<210> 3742
<211> 747
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<400> 3742
Met Glu Gly Ser Lys Xaa Pro Leu Gln Ser Ser Pro Ser Ala Gln Glu 
1               5                   10                  15      


Leu Lys Ala Pro Leu Glu Arg Arg His Ser Ser Ser Ser Lys Pro Pro 
            20                  25                  30          


Leu Ala Val Pro Pro Xaa Ser Val Phe Ser Phe Phe Pro Ser Leu Ser 
        35                  40                  45              


Lys Ser Lys Gly Gly Ser Ala Ser Gly Ser Asn Arg Ser Ser Ser Gly 
    50                  55                  60                  


Gly Val Leu Ser Ala Ser Ser Ser Ser Ser Lys Leu Leu Lys Ser Pro 
65                  70                  75                  80  


Lys Glu Lys Leu Gln Leu Arg Gly Asn Xaa Arg Pro Met His Pro Ile 
                85                  90                  95      


Gln Gln Ser Arg Val Pro His Gly Arg Ile Met Xaa Pro Ser Val Lys 
            100                 105                 110         


Val Glu Lys Ile His Pro Lys Met Asp Gly Xaa Leu Leu Lys Ser Ala 
        115                 120                 125             


Val Gly Pro Xaa Cys Pro Ala Xaa Val Ser Ser Leu Val Lys Pro Gly 
    130                 135                 140                 


Leu Asn Cys Pro Ser Ile Pro Lys Pro Xaa Leu Pro Ser Pro Gly Gln 
145                 150                 155                 160 


Ile Leu Asn Gly Lys Gly Leu Pro Ala Pro Pro Xaa Leu Glu Lys Lys 
                165                 170                 175     


Pro Glu Asp Asn Ser Asn Asn Arg Lys Phe Leu Asn Lys Arg Leu Ser 
            180                 185                 190         


Glu Arg Glu Phe Asp Pro Asp Ile His Cys Gly Val Ile Asp Leu Asp 
        195                 200                 205             


Xaa Lys Lys Pro Cys Xaa Arg Ser Leu Xaa Cys Lys Xaa His Ser Leu 
    210                 215                 220                 


Xaa Gln Arg Arg Ala Val Gln Gly Arg Arg Lys Arg Phe Asp Val Leu 
225                 230                 235                 240 


Leu Ala Glu His Lys Asn Lys Xaa Arg Glu Lys Glu Leu Ile Arg His 
                245                 250                 255     


Pro Asp Ser Gln Gln Pro Pro Gln Pro Leu Arg Asp Pro His Pro Ala 
            260                 265                 270         


Pro Pro Arg Xaa Ser Gln Glu Pro His Gln Asn Pro His Gly Val Ile 
        275                 280                 285             


Pro Ser Glu Ser Lys Pro Phe Val Ala Ser Lys Pro Lys Pro His Xaa 
    290                 295                 300                 


Pro Ser Leu Pro Arg Pro Pro Gly Cys Pro Ala Gln Gln Gly Gly Ser 
305                 310                 315                 320 


Ala Pro Ile Asp Pro Pro Pro Val His Glu Ser Pro His Pro Pro Leu 
                325                 330                 335     


Pro Ala Xaa Glu Pro Ala Ser Arg Leu Ser Ser Glu Glu Gly Glu Gly 
            340                 345                 350         


Asp Asp Lys Glu Glu Ser Val Glu Lys Leu Asp Cys His Tyr Ser Gly 
        355                 360                 365             


His His Pro Gln Pro Ala Ser Phe Cys Xaa Phe Gly Ser Arg Gln Ile 
    370                 375                 380                 


Gly Arg Gly Tyr Tyr Val Phe Asp Ser Arg Trp Asn Arg Leu Arg Cys 
385                 390                 395                 400 


Ala Leu Asn Leu Met Val Glu Lys His Leu Asn Ala Gln Leu Trp Lys 
                405                 410                 415     


Lys Ile Pro Pro Val Pro Ser Xaa Xaa Ser Pro Ile Ser Xaa Arg Ile 
            420                 425                 430         


Pro His Arg Xaa Asn Ser Val Pro Xaa Ser Gln Cys Gly Val Ser Tyr 
        435                 440                 445             


Leu Ala Ala Ala Xaa Val Ser Xaa Ser Pro Val Leu Leu Ser Ser Xaa 
    450                 455                 460                 


Cys Ile Ser Pro Asn Ser Lys Ser Val Pro Ala His Gly Xaa Xaa Leu 
465                 470                 475                 480 


Asn Ala Gln Pro Ala Ala Ser Gly Ala Met Asp Pro Val Cys Ser Met 
                485                 490                 495     


Gln Ser Arg Gln Val Ser Ser Ser Ser Ser Ser Pro Ser Xaa Pro Ser 
            500                 505                 510         


Gly Leu Ser Ser Val Pro Ser Ser Pro Met Ser Arg Lys Pro Gln Lys 
        515                 520                 525             


Leu Lys Ser Ser Lys Ser Leu Arg Pro Lys Glu Ser Ser Gly Asn Ser 
    530                 535                 540                 


Xaa Asn Cys Gln Asn Ala Ser Ser Ser Xaa Ser Gly Gly Ser Gly Lys 
545                 550                 555                 560 


Lys Arg Lys Asn Ser Ser Pro Leu Leu Val His Ser Ser Ser Ser Ser 
                565                 570                 575     


Ser Ser Ser Ser Ser Ser Ser His Ser Met Glu Ser Phe Arg Lys Asn 
            580                 585                 590         


Cys Val Ala His Ser Gly Pro Pro Tyr Pro Ser Xaa Val Xaa Ser Ser 
        595                 600                 605             


His Ser Ile Gly Leu Asn Cys Val Xaa Asn Lys Ala Asn Ala Val Asn 
    610                 615                 620                 


Val Arg His Asp Gln Ser Gly Arg Gly Pro Pro Xaa Gly Ser Pro Ala 
625                 630                 635                 640 


Glu Ser Ile Lys Arg Met Ser Val Met Val Asn Ser Ser Asp Ser Xaa 
                645                 650                 655     


Leu Ser Leu Gly Pro Phe Ile His Gln Ser Asn Glu Leu Pro Val Asn 
            660                 665                 670         


Ser His Gly Ser Phe Ser His Ser His Xaa Pro Leu Asp Lys Leu Ile 
        675                 680                 685             


Gly Lys Lys Arg Lys Cys Ser Pro Ser Ser Ser Ser Ile Asn Asn Ser 
    690                 695                 700                 


Ser Ser Lys Pro Xaa Lys Val Ala Lys Val Pro Ala Val Asn Asn Val 
705                 710                 715                 720 


His Met Lys His Xaa Gly Xaa Ile Pro Gly Ala Gln Gly Leu Met Asn 
                725                 730                 735     


Ser Ser Leu Leu His Gln Pro Lys Ala Arg Pro 
            740                 745         


<210> 3743
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3743
Met Ser Glu Arg Ala Ala Asp Asp Val Arg Gly Glu Pro Arg Arg Ala 
1               5                   10                  15      


Ala Ala Ala Ala Gly Gly Ala Ala Ala Ala 
            20                  25      


<210> 3744
<211> 892
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<400> 3744
Met Ser Glu Arg Ala Ala Asp Asp Val Arg Gly Glu Pro Arg Arg Ala 
1               5                   10                  15      


Ala Ala Ala Ala Gly Gly Ala Ala Ala Ala Ala Ala Arg Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Gln Pro Gln Arg Gln 
        35                  40                  45              


Gln His Pro Pro Pro Pro Pro Arg Arg Xaa Arg Pro Glu Asp Gly Gly 
    50                  55                  60                  


Pro Gly Ala Ala Ser Xaa Ser Ala Ala Ala Met Ala Xaa Val Gly Glu 
65                  70                  75                  80  


Arg Arg Pro Leu Pro Ser Pro Glu Val Met Leu Gly Gln Ser Trp Asn 
                85                  90                  95      


Leu Trp Val Glu Ala Ser Lys Leu Pro Gly Lys Asp Gly Xaa Glu Leu 
            100                 105                 110         


Asp Glu Ser Phe Lys Glu Phe Gly Lys Asn Arg Glu Val Met Gly Leu 
        115                 120                 125             


Cys Arg Glu Asp Met Pro Ile Phe Gly Phe Cys Pro Ala His Asp Asp 
    130                 135                 140                 


Phe Tyr Leu Val Val Cys Asn Asp Cys Asn Gln Val Val Lys Pro Gln 
145                 150                 155                 160 


Ala Phe Gln Ser His Tyr Glu Arg Arg His Ser Ser Ser Ser Lys Pro 
                165                 170                 175     


Pro Leu Ala Val Pro Pro Xaa Ser Val Phe Ser Phe Phe Pro Ser Leu 
            180                 185                 190         


Ser Lys Ser Lys Gly Gly Ser Ala Ser Gly Ser Asn Arg Ser Ser Ser 
        195                 200                 205             


Gly Gly Val Leu Ser Ala Ser Ser Ser Ser Ser Lys Leu Leu Lys Ser 
    210                 215                 220                 


Pro Lys Glu Lys Leu Gln Leu Arg Gly Asn Xaa Arg Pro Met His Pro 
225                 230                 235                 240 


Ile Gln Gln Ser Arg Val Pro His Gly Arg Ile Met Xaa Pro Ser Val 
                245                 250                 255     


Lys Val Glu Lys Ile His Pro Lys Met Asp Gly Xaa Leu Leu Lys Ser 
            260                 265                 270         


Ala Val Gly Pro Xaa Cys Pro Ala Xaa Val Ser Ser Leu Val Lys Pro 
        275                 280                 285             


Gly Leu Asn Cys Pro Ser Ile Pro Lys Pro Xaa Leu Pro Ser Pro Gly 
    290                 295                 300                 


Gln Ile Leu Asn Gly Lys Gly Leu Pro Ala Pro Pro Xaa Leu Glu Lys 
305                 310                 315                 320 


Lys Pro Glu Asp Asn Ser Asn Asn Arg Lys Phe Leu Asn Lys Arg Leu 
                325                 330                 335     


Ser Glu Arg Glu Phe Asp Pro Asp Ile His Cys Gly Val Ile Asp Leu 
            340                 345                 350         


Asp Xaa Lys Lys Pro Cys Xaa Arg Ser Leu Xaa Cys Lys Xaa His Ser 
        355                 360                 365             


Leu Xaa Gln Arg Arg Ala Val Gln Gly Arg Arg Lys Arg Phe Asp Val 
    370                 375                 380                 


Leu Leu Ala Glu His Lys Asn Lys Xaa Arg Glu Lys Glu Leu Ile Arg 
385                 390                 395                 400 


His Pro Asp Ser Gln Gln Pro Pro Gln Pro Leu Arg Asp Pro His Pro 
                405                 410                 415     


Ala Pro Pro Arg Xaa Ser Gln Glu Pro His Gln Asn Pro His Gly Val 
            420                 425                 430         


Ile Pro Ser Glu Ser Lys Pro Phe Val Ala Ser Lys Pro Lys Pro His 
        435                 440                 445             


Xaa Pro Ser Leu Pro Arg Pro Pro Gly Cys Pro Ala Gln Gln Gly Gly 
    450                 455                 460                 


Ser Ala Pro Ile Asp Pro Pro Pro Val His Glu Ser Pro His Pro Pro 
465                 470                 475                 480 


Leu Pro Ala Xaa Glu Pro Ala Ser Arg Leu Ser Ser Glu Glu Gly Glu 
                485                 490                 495     


Gly Asp Asp Lys Glu Glu Ser Val Glu Lys Leu Asp Cys His Tyr Ser 
            500                 505                 510         


Gly His His Pro Gln Pro Ala Ser Phe Cys Xaa Phe Gly Ser Arg Gln 
        515                 520                 525             


Ile Gly Arg Gly Tyr Tyr Val Phe Asp Ser Arg Trp Asn Arg Leu Arg 
    530                 535                 540                 


Cys Ala Leu Asn Leu Met Val Glu Lys His Leu Asn Ala Gln Leu Trp 
545                 550                 555                 560 


Lys Lys Ile Pro Pro Val Pro Ser Xaa Xaa Ser Pro Ile Ser Xaa Arg 
                565                 570                 575     


Ile Pro His Arg Xaa Asn Ser Val Pro Xaa Ser Gln Cys Gly Val Ser 
            580                 585                 590         


Tyr Leu Ala Ala Ala Xaa Val Ser Xaa Ser Pro Val Leu Leu Ser Ser 
        595                 600                 605             


Xaa Cys Ile Ser Pro Asn Ser Lys Ser Val Pro Ala His Gly Xaa Xaa 
    610                 615                 620                 


Leu Asn Ala Gln Pro Ala Ala Ser Gly Ala Met Asp Pro Val Cys Ser 
625                 630                 635                 640 


Met Gln Ser Arg Gln Val Ser Ser Ser Ser Ser Ser Pro Ser Xaa Pro 
                645                 650                 655     


Ser Gly Leu Ser Ser Val Pro Ser Ser Pro Met Ser Arg Lys Pro Gln 
            660                 665                 670         


Lys Leu Lys Ser Ser Lys Ser Leu Arg Pro Lys Glu Ser Ser Gly Asn 
        675                 680                 685             


Ser Xaa Asn Cys Gln Asn Ala Ser Ser Ser Xaa Ser Gly Gly Ser Gly 
    690                 695                 700                 


Lys Lys Arg Lys Asn Ser Ser Pro Leu Leu Val His Ser Ser Ser Ser 
705                 710                 715                 720 


Ser Ser Ser Ser Ser Ser Ser Ser His Ser Met Glu Ser Phe Arg Lys 
                725                 730                 735     


Asn Cys Val Ala His Ser Gly Pro Pro Tyr Pro Ser Xaa Val Xaa Ser 
            740                 745                 750         


Ser His Ser Ile Gly Leu Asn Cys Val Xaa Asn Lys Ala Asn Ala Val 
        755                 760                 765             


Asn Val Arg His Asp Gln Ser Gly Arg Gly Pro Pro Xaa Gly Ser Pro 
    770                 775                 780                 


Ala Glu Ser Ile Lys Arg Met Ser Val Met Val Asn Ser Ser Asp Ser 
785                 790                 795                 800 


Xaa Leu Ser Leu Gly Pro Phe Ile His Gln Ser Asn Glu Leu Pro Val 
                805                 810                 815     


Asn Ser His Gly Ser Phe Ser His Ser His Xaa Pro Leu Asp Lys Leu 
            820                 825                 830         


Ile Gly Lys Lys Arg Lys Cys Ser Pro Ser Ser Ser Ser Ile Asn Asn 
        835                 840                 845             


Ser Ser Ser Lys Pro Xaa Lys Val Ala Lys Val Pro Ala Val Asn Asn 
    850                 855                 860                 


Val His Met Lys His Xaa Gly Xaa Ile Pro Gly Ala Gln Gly Leu Met 
865                 870                 875                 880 


Asn Ser Ser Leu Leu His Gln Pro Lys Ala Arg Pro 
                885                 890         


<210> 3745
<211> 945
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<400> 3745
Met Ser Glu Arg Ala Ala Asp Asp Val Arg Gly Glu Pro Arg Arg Ala 
1               5                   10                  15      


Ala Ala Ala Ala Gly Gly Ala Ala Ala Ala Ala Ala Arg Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Gln Pro Gln Arg Gln 
        35                  40                  45              


Gln His Pro Pro Pro Pro Pro Arg Arg Xaa Arg Pro Glu Asp Gly Gly 
    50                  55                  60                  


Pro Gly Ala Ala Ser Xaa Ser Ala Ala Ala Met Ala Xaa Val Gly Glu 
65                  70                  75                  80  


Arg Arg Pro Leu Pro Ser Pro Glu Val Met Leu Gly Gln Ser Trp Asn 
                85                  90                  95      


Leu Trp Val Glu Ala Ser Lys Leu Pro Gly Lys Asp Gly Xaa Glu Leu 
            100                 105                 110         


Asp Glu Ser Phe Lys Glu Phe Gly Lys Asn Arg Glu Val Met Gly Leu 
        115                 120                 125             


Cys Arg Glu Asp Met Pro Ile Phe Gly Phe Cys Pro Ala His Asp Asp 
    130                 135                 140                 


Phe Tyr Leu Val Val Cys Asn Asp Cys Asn Gln Val Val Lys Pro Gln 
145                 150                 155                 160 


Ala Phe Gln Ser His Tyr Glu Arg Arg His Ser Ser Ser Ser Lys Pro 
                165                 170                 175     


Pro Leu Ala Val Pro Pro Xaa Ser Val Phe Ser Phe Phe Pro Ser Leu 
            180                 185                 190         


Ser Lys Ser Lys Gly Gly Ser Ala Ser Gly Ser Asn Arg Ser Ser Ser 
        195                 200                 205             


Gly Gly Val Leu Ser Ala Ser Ser Ser Ser Ser Lys Leu Leu Lys Ser 
    210                 215                 220                 


Pro Lys Glu Lys Leu Gln Leu Arg Gly Asn Xaa Arg Pro Met His Pro 
225                 230                 235                 240 


Ile Gln Gln Ser Arg Val Pro His Gly Arg Ile Met Xaa Pro Ser Val 
                245                 250                 255     


Lys Val Glu Lys Ile His Pro Lys Met Asp Gly Xaa Leu Leu Lys Ser 
            260                 265                 270         


Ala Val Gly Pro Xaa Cys Pro Ala Xaa Val Ser Ser Leu Val Lys Pro 
        275                 280                 285             


Gly Leu Asn Cys Pro Ser Ile Pro Lys Pro Xaa Leu Pro Ser Pro Gly 
    290                 295                 300                 


Gln Ile Leu Asn Gly Lys Gly Leu Pro Ala Pro Pro Xaa Leu Glu Lys 
305                 310                 315                 320 


Lys Pro Glu Asp Asn Ser Asn Asn Arg Lys Phe Leu Asn Lys Arg Leu 
                325                 330                 335     


Ser Glu Arg Glu Phe Asp Pro Asp Ile His Cys Gly Val Ile Asp Leu 
            340                 345                 350         


Asp Xaa Lys Lys Pro Cys Xaa Arg Ser Leu Xaa Cys Lys Xaa His Ser 
        355                 360                 365             


Leu Xaa Gln Arg Arg Ala Val Gln Gly Arg Arg Lys Arg Phe Asp Val 
    370                 375                 380                 


Leu Leu Ala Glu His Lys Asn Lys Xaa Arg Glu Lys Glu Leu Ile Arg 
385                 390                 395                 400 


His Pro Asp Ser Gln Gln Pro Pro Gln Pro Leu Arg Asp Pro His Pro 
                405                 410                 415     


Ala Pro Pro Arg Xaa Ser Gln Glu Pro His Gln Asn Pro His Gly Val 
            420                 425                 430         


Ile Pro Ser Glu Ser Lys Pro Phe Val Ala Ser Lys Pro Lys Pro His 
        435                 440                 445             


Xaa Pro Ser Leu Pro Arg Pro Pro Gly Cys Pro Ala Gln Gln Gly Gly 
    450                 455                 460                 


Ser Ala Pro Ile Asp Pro Pro Pro Val His Glu Ser Pro His Pro Pro 
465                 470                 475                 480 


Leu Pro Ala Xaa Glu Pro Ala Ser Arg Leu Ser Ser Glu Glu Gly Glu 
                485                 490                 495     


Gly Asp Asp Lys Glu Glu Ser Val Glu Lys Leu Asp Cys His Tyr Ser 
            500                 505                 510         


Gly His His Pro Gln Pro Ala Ser Phe Cys Xaa Phe Gly Ser Arg Gln 
        515                 520                 525             


Ile Gly Arg Gly Tyr Tyr Val Phe Asp Ser Arg Trp Asn Arg Leu Arg 
    530                 535                 540                 


Cys Ala Leu Asn Leu Met Val Glu Lys His Leu Asn Ala Gln Leu Trp 
545                 550                 555                 560 


Lys Lys Ile Pro Pro Val Pro Ser Xaa Xaa Ser Pro Ile Ser Xaa Arg 
                565                 570                 575     


Ile Pro His Arg Xaa Asn Ser Val Pro Xaa Ser Gln Cys Gly Val Ser 
            580                 585                 590         


Tyr Leu Ala Ala Ala Xaa Val Ser Xaa Ser Pro Val Leu Leu Ser Ser 
        595                 600                 605             


Xaa Cys Ile Ser Pro Asn Ser Lys Ser Val Pro Ala His Gly Xaa Xaa 
    610                 615                 620                 


Leu Asn Ala Gln Pro Ala Ala Ser Gly Ala Met Asp Pro Val Cys Ser 
625                 630                 635                 640 


Met Gln Ser Arg Gln Val Ser Ser Ser Ser Ser Ser Pro Ser Xaa Pro 
                645                 650                 655     


Ser Gly Leu Ser Ser Val Pro Ser Ser Pro Met Ser Arg Lys Pro Gln 
            660                 665                 670         


Lys Leu Lys Ser Ser Lys Ser Leu Arg Pro Lys Glu Ser Ser Gly Asn 
        675                 680                 685             


Ser Xaa Asn Cys Gln Asn Ala Ser Ser Ser Xaa Ser Gly Gly Ser Gly 
    690                 695                 700                 


Lys Lys Arg Lys Asn Ser Ser Pro Leu Leu Val His Ser Ser Ser Ser 
705                 710                 715                 720 


Ser Ser Ser Ser Ser Ser Ser Ser His Ser Met Glu Ser Phe Arg Lys 
                725                 730                 735     


Asn Cys Val Ala His Ser Gly Pro Pro Tyr Pro Ser Xaa Val Xaa Ser 
            740                 745                 750         


Ser His Ser Ile Gly Leu Asn Cys Val Xaa Asn Lys Ala Asn Ala Val 
        755                 760                 765             


Asn Val Arg His Asp Gln Ser Gly Arg Gly Pro Pro Xaa Gly Ser Pro 
    770                 775                 780                 


Ala Glu Ser Ile Lys Arg Met Ser Val Met Val Asn Ser Ser Asp Ser 
785                 790                 795                 800 


Xaa Leu Ser Leu Gly Pro Phe Ile His Gln Ser Asn Glu Leu Pro Val 
                805                 810                 815     


Asn Ser His Gly Ser Phe Ser His Ser His Xaa Pro Leu Asp Lys Leu 
            820                 825                 830         


Ile Gly Lys Lys Arg Lys Cys Ser Pro Ser Ser Ser Ser Ile Asn Asn 
        835                 840                 845             


Ser Ser Ser Lys Pro Xaa Lys Val Ala Lys Val Pro Ala Val Asn Asn 
    850                 855                 860                 


Val His Met Lys His Xaa Gly Xaa Ile Pro Gly Ala Gln Gly Leu Met 
865                 870                 875                 880 


Asn Ser Ser Leu Leu His Gln Asp Ile Ser Ser Pro Cys Leu Arg Xaa 
                885                 890                 895     


Gly Ile Ser Ala Xaa Ser Pro Gln Ser Pro Asp Leu Lys Ser Lys Gly 
            900                 905                 910         


Xaa Ser Leu Xaa Ala Glu Asn Ser Xaa Gly Arg Asn Asn Ala Asp Xaa 
        915                 920                 925             


Phe Glu Asp Lys Leu His Leu His Ser Ala Leu Trp Xaa Pro Arg Cys 
    930                 935                 940                 


Leu 
945 


<210> 3746
<211> 79
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<400> 3746
Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Xaa 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Xaa Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu 
65                  70                  75                  


<210> 3747
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 3747
Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Xaa 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Xaa Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Xaa Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Xaa Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro 
            100                 105     


<210> 3748
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 3748
Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Xaa 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Xaa Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Xaa Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Xaa Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val 
145         


<210> 3749
<211> 189
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 3749
Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Xaa 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Xaa Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Xaa Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Xaa Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg 
            180                 185                 


<210> 3750
<211> 271
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<400> 3750
Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Xaa 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Xaa Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Xaa Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Xaa Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Xaa Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Xaa Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Xaa Ala Xaa Tyr Ile Xaa Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys 
            260                 265                 270     


<210> 3751
<211> 347
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<400> 3751
Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Xaa 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Xaa Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Xaa Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Xaa Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Xaa Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Xaa Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Xaa Ala Xaa Tyr Ile Xaa Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Xaa Xaa 
        275                 280                 285             


Leu Cys Gly Xaa Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Xaa Tyr Gln Glu 
                325                 330                 335     


Xaa Tyr Lys Arg Ile Ser Arg Val Arg Arg Asn 
            340                 345         


<210> 3752
<211> 403
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<400> 3752
Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Xaa 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Xaa Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Xaa Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Xaa Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Xaa Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Xaa Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Xaa Ala Xaa Tyr Ile Xaa Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Xaa Xaa 
        275                 280                 285             


Leu Cys Gly Xaa Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Xaa Tyr Gln Glu 
                325                 330                 335     


Xaa Tyr Lys Arg Ile Ser Arg Val Glu Phe Xaa Phe Pro Asp Phe Val 
            340                 345                 350         


Xaa Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Xaa 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser 
            


<210> 3753
<211> 312
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<400> 3753
Met Ala Gln Lys Glu Asn Ser Tyr Pro Trp Pro Tyr Gly Arg Gln Xaa 
1               5                   10                  15      


Ala Pro Ser Gly Leu Ser Xaa Leu Pro Gln Arg Val Leu Arg Lys Glu 
            20                  25                  30          


Pro Val Xaa Pro Ser Ala Leu Val Leu Met Ser Arg Ser Asn Val Gln 
        35                  40                  45              


Pro Xaa Ala Ala Pro Gly Gln Lys Val Met Glu Asn Ser Ser Gly Xaa 
    50                  55                  60                  


Pro Asp Ile Leu Xaa Arg His Phe Xaa Ile Asp Asp Phe Glu Ile Gly 
65                  70                  75                  80  


Arg Pro Leu Gly Lys Ala Leu Leu Cys Leu Trp Pro Glu Ala Ser Ser 
                85                  90                  95      


Val Ser Ser Pro Ser His Pro Asn Ile Leu Arg Leu Tyr Asn Tyr Phe 
            100                 105                 110         


Tyr Asp Arg Arg Arg Ile Tyr Leu Ile Leu Glu Tyr Ala Pro Arg Gly 
        115                 120                 125             


Glu Leu Tyr Lys Glu Leu Gln Lys Ser Cys Xaa Phe Asp Glu Gln Arg 
    130                 135                 140                 


Xaa Ala Xaa Ile Met Glu Glu Leu Ala Asp Ala Leu Met Tyr Cys His 
145                 150                 155                 160 


Gly Lys Lys Val Ile His Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu 
                165                 170                 175     


Gly Leu Lys Gly Glu Leu Lys Ile Ala Asp Phe Gly Trp Ser Val His 
            180                 185                 190         


Ala Pro Ser Leu Arg Arg Lys Xaa Met Cys Gly Xaa Leu Asp Tyr Leu 
        195                 200                 205             


Pro Pro Glu Met Ile Glu Gly Arg Met His Asn Glu Lys Val Asp Leu 
    210                 215                 220                 


Trp Cys Ile Gly Val Leu Cys Tyr Glu Leu Leu Val Gly Asn Pro Pro 
225                 230                 235                 240 


Phe Glu Ser Ala Ser His Asn Glu Xaa Tyr Arg Arg Ile Val Lys Val 
                245                 250                 255     


Asp Leu Lys Phe Pro Ala Ser Val Pro Met Gly Ala Gln Asp Leu Ile 
            260                 265                 270         


Ser Lys Leu Leu Arg His Asn Pro Ser Glu Arg Leu Pro Leu Ala Gln 
        275                 280                 285             


Val Ser Ala His Pro Trp Val Arg Ala Asn Ser Arg Arg Val Leu Pro 
    290                 295                 300                 


Pro Ser Ala Leu Gln Ser Val Ala 
305                 310         


<210> 3754
<211> 123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<400> 3754
Met Ala Gln Lys Glu Asn Ser Tyr Pro Trp Pro Tyr Gly Arg Gln Xaa 
1               5                   10                  15      


Ala Pro Ser Gly Leu Ser Xaa Leu Pro Gln Arg Val Leu Arg Lys Glu 
            20                  25                  30          


Pro Val Xaa Pro Ser Ala Leu Val Leu Met Ser Arg Ser Asn Val Gln 
        35                  40                  45              


Pro Xaa Ala Ala Pro Gly Gln Lys Val Met Glu Asn Ser Ser Gly Xaa 
    50                  55                  60                  


Pro Asp Ile Leu Xaa Arg His Phe Xaa Ile Asp Asp Phe Glu Ile Gly 
65                  70                  75                  80  


Arg Pro Leu Gly Lys Asp His Gly Gly Val Gly Arg Cys Ser Asn Val 
                85                  90                  95      


Leu Pro Trp Glu Glu Gly Asp Ser Gln Arg His Lys Ala Arg Lys Ser 
            100                 105                 110         


Ala Leu Arg Ala Gln Gly Arg Ala Glu Asp Cys 
        115                 120             


<210> 3755
<211> 228
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<400> 3755
Met Ala Gln Lys Glu Asn Ser Tyr Pro Trp Pro Tyr Gly Arg Gln Xaa 
1               5                   10                  15      


Ala Pro Ser Gly Leu Ser Xaa Leu Pro Gln Arg Val Leu Arg Lys Glu 
            20                  25                  30          


Pro Val Xaa Pro Ser Ala Leu Val Leu Met Ser Arg Ser Asn Val Gln 
        35                  40                  45              


Pro Xaa Ala Ala Pro Gly Gln Lys Val Met Glu Asn Ser Ser Gly Xaa 
    50                  55                  60                  


Pro Asp Ile Leu Xaa Arg His Phe Xaa Ile Asp Asp Phe Glu Ile Gly 
65                  70                  75                  80  


Arg Pro Leu Gly Lys Gly Lys Phe Gly Asn Val Tyr Leu Ala Arg Glu 
                85                  90                  95      


Lys Lys Ser His Phe Ile Val Ala Leu Lys Val Leu Phe Lys Ser Gln 
            100                 105                 110         


Ile Glu Lys Glu Gly Val Glu His Gln Leu Arg Arg Glu Ile Glu Ile 
        115                 120                 125             


Gln Ala His Leu His His Pro Asn Ile Leu Arg Leu Tyr Asn Tyr Phe 
    130                 135                 140                 


Tyr Asp Arg Arg Arg Ile Tyr Leu Ile Leu Glu Tyr Ala Pro Arg Gly 
145                 150                 155                 160 


Glu Leu Tyr Lys Glu Leu Gln Lys Ser Cys Xaa Phe Asp Glu Gln Arg 
                165                 170                 175     


Xaa Ala Xaa Ile Met Glu Glu Leu Ala Asp Ala Leu Met Tyr Cys His 
            180                 185                 190         


Gly Lys Lys Val Ile His Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu 
        195                 200                 205             


Gly Leu Lys Gly Glu Leu Lys Ile Ala Asp Phe Gly Trp Ser Val His 
    210                 215                 220                 


Ala Pro Ser Leu 
225             


<210> 3756
<211> 344
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<400> 3756
Met Ala Gln Lys Glu Asn Ser Tyr Pro Trp Pro Tyr Gly Arg Gln Xaa 
1               5                   10                  15      


Ala Pro Ser Gly Leu Ser Xaa Leu Pro Gln Arg Val Leu Arg Lys Glu 
            20                  25                  30          


Pro Val Xaa Pro Ser Ala Leu Val Leu Met Ser Arg Ser Asn Val Gln 
        35                  40                  45              


Pro Xaa Ala Ala Pro Gly Gln Lys Val Met Glu Asn Ser Ser Gly Xaa 
    50                  55                  60                  


Pro Asp Ile Leu Xaa Arg His Phe Xaa Ile Asp Asp Phe Glu Ile Gly 
65                  70                  75                  80  


Arg Pro Leu Gly Lys Gly Lys Phe Gly Asn Val Tyr Leu Ala Arg Glu 
                85                  90                  95      


Lys Lys Ser His Phe Ile Val Ala Leu Lys Val Leu Phe Lys Ser Gln 
            100                 105                 110         


Ile Glu Lys Glu Gly Val Glu His Gln Leu Arg Arg Glu Ile Glu Ile 
        115                 120                 125             


Gln Ala His Leu His His Pro Asn Ile Leu Arg Leu Tyr Asn Tyr Phe 
    130                 135                 140                 


Tyr Asp Arg Arg Arg Ile Tyr Leu Ile Leu Glu Tyr Ala Pro Arg Gly 
145                 150                 155                 160 


Glu Leu Tyr Lys Glu Leu Gln Lys Ser Cys Xaa Phe Asp Glu Gln Arg 
                165                 170                 175     


Xaa Ala Xaa Ile Met Glu Glu Leu Ala Asp Ala Leu Met Tyr Cys His 
            180                 185                 190         


Gly Lys Lys Val Ile His Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu 
        195                 200                 205             


Gly Leu Lys Gly Glu Leu Lys Ile Ala Asp Phe Gly Trp Ser Val His 
    210                 215                 220                 


Ala Pro Ser Leu Arg Arg Lys Xaa Met Cys Gly Xaa Leu Asp Tyr Leu 
225                 230                 235                 240 


Pro Pro Glu Met Ile Glu Gly Arg Met His Asn Glu Lys Val Asp Leu 
                245                 250                 255     


Trp Cys Ile Gly Val Leu Cys Tyr Glu Leu Leu Val Gly Asn Pro Pro 
            260                 265                 270         


Phe Glu Ser Ala Ser His Asn Glu Xaa Tyr Arg Arg Ile Val Lys Val 
        275                 280                 285             


Asp Leu Lys Phe Pro Ala Ser Val Pro Met Gly Ala Gln Asp Leu Ile 
    290                 295                 300                 


Ser Lys Leu Leu Arg His Asn Pro Ser Glu Arg Leu Pro Leu Ala Gln 
305                 310                 315                 320 


Val Ser Ala His Pro Trp Val Arg Ala Asn Ser Arg Arg Val Leu Pro 
                325                 330                 335     


Pro Ser Ala Leu Gln Ser Val Ala 
            340                 


<210> 3757
<211> 345
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<400> 3757
Met Ala Gln Lys Glu Asn Ser Tyr Pro Trp Pro Tyr Gly Arg Gln Xaa 
1               5                   10                  15      


Ala Pro Ser Gly Leu Ser Xaa Leu Pro Gln Arg Val Leu Arg Lys Glu 
            20                  25                  30          


Pro Val Xaa Pro Ser Ala Leu Val Leu Met Ser Arg Ser Asn Val Gln 
        35                  40                  45              


Pro Xaa Ala Ala Pro Gly Gln Lys Val Met Glu Asn Ser Ser Gly Xaa 
    50                  55                  60                  


Pro Asp Ile Leu Xaa Arg Arg His Phe Xaa Ile Asp Asp Phe Glu Ile 
65                  70                  75                  80  


Gly Arg Pro Leu Gly Lys Gly Lys Phe Gly Asn Val Tyr Leu Ala Arg 
                85                  90                  95      


Glu Lys Lys Ser His Phe Ile Val Ala Leu Lys Val Leu Phe Lys Ser 
            100                 105                 110         


Gln Ile Glu Lys Glu Gly Val Glu His Gln Leu Arg Arg Glu Ile Glu 
        115                 120                 125             


Ile Gln Ala His Leu His His Pro Asn Ile Leu Arg Leu Tyr Asn Tyr 
    130                 135                 140                 


Phe Tyr Asp Arg Arg Arg Ile Tyr Leu Ile Leu Glu Tyr Ala Pro Arg 
145                 150                 155                 160 


Gly Glu Leu Tyr Lys Glu Leu Gln Lys Ser Cys Xaa Phe Asp Glu Gln 
                165                 170                 175     


Arg Xaa Ala Xaa Ile Met Glu Glu Leu Ala Asp Ala Leu Met Tyr Cys 
            180                 185                 190         


His Gly Lys Lys Val Ile His Arg Asp Ile Lys Pro Glu Asn Leu Leu 
        195                 200                 205             


Leu Gly Leu Lys Gly Glu Leu Lys Ile Ala Asp Phe Gly Trp Ser Val 
    210                 215                 220                 


His Ala Pro Ser Leu Arg Arg Lys Xaa Met Cys Gly Xaa Leu Asp Tyr 
225                 230                 235                 240 


Leu Pro Pro Glu Met Ile Glu Gly Arg Met His Asn Glu Lys Val Asp 
                245                 250                 255     


Leu Trp Cys Ile Gly Val Leu Cys Tyr Glu Leu Leu Val Gly Asn Pro 
            260                 265                 270         


Pro Phe Glu Ser Ala Ser His Asn Glu Xaa Tyr Arg Arg Ile Val Lys 
        275                 280                 285             


Val Asp Leu Lys Phe Pro Ala Ser Val Pro Met Gly Ala Gln Asp Leu 
    290                 295                 300                 


Ile Ser Lys Leu Leu Arg His Asn Pro Ser Glu Arg Leu Pro Leu Ala 
305                 310                 315                 320 


Gln Val Ser Ala His Pro Trp Val Arg Ala Asn Ser Arg Arg Val Leu 
                325                 330                 335     


Pro Pro Ser Ala Leu Gln Ser Val Ala 
            340                 345 


<210> 3758
<211> 70
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<400> 3758
Met Ser Arg Ser Asn Val Gln Pro Xaa Ala Ala Pro Gly Gln Lys Val 
1               5                   10                  15      


Met Glu Asn Ser Ser Gly Xaa Pro Asp Ile Leu Xaa Arg His Phe Xaa 
            20                  25                  30          


Ile Asp Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe Gly 
        35                  40                  45              


Asn Val Tyr Leu Ala Arg Glu Lys Lys Ser His Phe Ile Val Ala Leu 
    50                  55                  60                  


Lys Val Leu Phe Lys Ser 
65                  70  


<210> 3759
<211> 172
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<400> 3759
Met Ser Arg Ser Asn Val Gln Pro Xaa Ala Ala Pro Gly Gln Lys Val 
1               5                   10                  15      


Met Glu Asn Ser Ser Gly Xaa Pro Asp Ile Leu Xaa Arg His Phe Xaa 
            20                  25                  30          


Ile Asp Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe Gly 
        35                  40                  45              


Asn Val Tyr Leu Ala Arg Glu Lys Lys Ser His Phe Ile Val Ala Leu 
    50                  55                  60                  


Lys Val Leu Phe Lys Ser Gln Ile Glu Lys Glu Gly Val Glu His Gln 
65                  70                  75                  80  


Leu Arg Arg Glu Ile Glu Ile Gln Ala His Leu His His Pro Asn Ile 
                85                  90                  95      


Leu Arg Leu Tyr Asn Tyr Phe Tyr Asp Arg Arg Arg Ile Tyr Leu Ile 
            100                 105                 110         


Leu Glu Tyr Ala Pro Arg Gly Glu Leu Tyr Lys Glu Leu Gln Lys Ser 
        115                 120                 125             


Cys Xaa Phe Asp Glu Gln Arg Xaa Ala Xaa Ile Met Glu Glu Leu Ala 
    130                 135                 140                 


Asp Ala Leu Met Tyr Cys His Gly Lys Lys Val Ile His Arg Asp Ile 
145                 150                 155                 160 


Lys Pro Glu Asn Leu Leu Leu Gly Leu Lys Gly Glu 
                165                 170         


<210> 3760
<211> 303
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<400> 3760
Met Ser Arg Ser Asn Val Gln Pro Xaa Ala Ala Pro Gly Gln Lys Val 
1               5                   10                  15      


Met Glu Asn Ser Ser Gly Xaa Pro Asp Ile Leu Xaa Arg His Phe Xaa 
            20                  25                  30          


Ile Asp Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe Gly 
        35                  40                  45              


Asn Val Tyr Leu Ala Arg Glu Lys Lys Ser His Phe Ile Val Ala Leu 
    50                  55                  60                  


Lys Val Leu Phe Lys Ser Gln Ile Glu Lys Glu Gly Val Glu His Gln 
65                  70                  75                  80  


Leu Arg Arg Glu Ile Glu Ile Gln Ala His Leu His His Pro Asn Ile 
                85                  90                  95      


Leu Arg Leu Tyr Asn Tyr Phe Tyr Asp Arg Arg Arg Ile Tyr Leu Ile 
            100                 105                 110         


Leu Glu Tyr Ala Pro Arg Gly Glu Leu Tyr Lys Glu Leu Gln Lys Ser 
        115                 120                 125             


Cys Xaa Phe Asp Glu Gln Arg Xaa Ala Xaa Ile Met Glu Glu Leu Ala 
    130                 135                 140                 


Asp Ala Leu Met Tyr Cys His Gly Lys Lys Val Ile His Arg Asp Ile 
145                 150                 155                 160 


Lys Pro Glu Asn Leu Leu Leu Gly Leu Lys Gly Glu Leu Lys Ile Ala 
                165                 170                 175     


Asp Phe Gly Trp Ser Val His Ala Pro Ser Leu Arg Arg Lys Xaa Met 
            180                 185                 190         


Cys Gly Xaa Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg Met 
        195                 200                 205             


His Asn Glu Lys Val Asp Leu Trp Cys Ile Gly Val Leu Cys Tyr Glu 
    210                 215                 220                 


Leu Leu Val Gly Asn Pro Pro Phe Glu Ser Ala Ser His Asn Glu Xaa 
225                 230                 235                 240 


Tyr Arg Arg Ile Val Lys Val Asp Leu Lys Phe Pro Ala Ser Val Pro 
                245                 250                 255     


Met Gly Ala Gln Asp Leu Ile Ser Lys Leu Leu Arg His Asn Pro Ser 
            260                 265                 270         


Glu Arg Leu Pro Leu Ala Gln Val Ser Ala His Pro Trp Val Arg Ala 
        275                 280                 285             


Asn Ser Arg Arg Val Leu Pro Pro Ser Ala Leu Gln Ser Val Ala 
    290                 295                 300             


<210> 3761
<211> 231
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<400> 3761
Met Ser Arg Ser Asn Val Gln Pro Xaa Ala Ala Pro Gly Gln Lys Val 
1               5                   10                  15      


Met Glu Asn Ser Ser Gly Xaa Pro Asp Ile Leu Xaa Arg Arg His Phe 
            20                  25                  30          


Xaa Ile Asp Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
        35                  40                  45              


Gly Asn Val Tyr Leu Ala Arg Glu Lys Lys Ser His Phe Ile Val Ala 
    50                  55                  60                  


Leu Lys Val Leu Phe Lys Ser Gln Ile Glu Lys Glu Gly Val Glu His 
65                  70                  75                  80  


Gln Leu Arg Arg Glu Ile Glu Ile Gln Ala His Leu His His Pro Asn 
                85                  90                  95      


Ile Leu Arg Leu Tyr Asn Tyr Phe Tyr Asp Arg Arg Arg Ile Tyr Leu 
            100                 105                 110         


Ile Leu Glu Tyr Ala Pro Arg Gly Glu Leu Tyr Lys Glu Leu Gln Lys 
        115                 120                 125             


Ser Cys Xaa Phe Asp Glu Gln Arg Xaa Ala Xaa Ile Met Glu Glu Leu 
    130                 135                 140                 


Ala Asp Ala Leu Met Tyr Cys His Gly Lys Lys Val Ile His Arg Asp 
145                 150                 155                 160 


Ile Lys Pro Glu Asn Leu Leu Leu Gly Leu Lys Gly Glu Leu Lys Ile 
                165                 170                 175     


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Leu Arg Arg Lys Xaa 
            180                 185                 190         


Met Cys Gly Xaa Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
        195                 200                 205             


Met His Asn Glu Lys Val Asp Leu Trp Cys Ile Gly Val Leu Cys Tyr 
    210                 215                 220                 


Glu Leu Leu Val Gly Asn Pro 
225                 230     


<210> 3762
<211> 242
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<400> 3762
Xaa Arg His Phe Xaa Ile Asp Asp Phe Glu Ile Gly Arg Pro Leu Gly 
1               5                   10                  15      


Lys Gly Lys Phe Gly Asn Val Tyr Leu Ala Arg Glu Lys Lys Ser His 
            20                  25                  30          


Phe Ile Val Ala Leu Lys Val Leu Phe Lys Ser Gln Ile Glu Lys Glu 
        35                  40                  45              


Gly Val Glu His Gln Leu Arg Arg Glu Ile Glu Ile Gln Ala His Leu 
    50                  55                  60                  


His His Pro Asn Ile Leu Arg Leu Tyr Asn Tyr Phe Tyr Asp Arg Arg 
65                  70                  75                  80  


Arg Ile Tyr Leu Ile Leu Glu Tyr Ala Pro Arg Gly Glu Leu Tyr Lys 
                85                  90                  95      


Glu Leu Gln Lys Ser Cys Xaa Phe Asp Glu Gln Arg Xaa Ala Xaa Ile 
            100                 105                 110         


Met Glu Glu Leu Ala Asp Ala Leu Met Tyr Cys His Gly Lys Lys Val 
        115                 120                 125             


Ile His Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Gly Leu Lys Gly 
    130                 135                 140                 


Glu Leu Lys Ile Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Leu 
145                 150                 155                 160 


Arg Arg Lys Xaa Met Cys Gly Xaa Leu Asp Tyr Leu Pro Pro Glu Met 
                165                 170                 175     


Ile Glu Gly Arg Met His Asn Glu Lys Val Asp Leu Lys Phe Pro Ala 
            180                 185                 190         


Ser Val Pro Met Gly Ala Gln Asp Leu Ile Ser Lys Leu Leu Arg His 
        195                 200                 205             


Asn Pro Ser Glu Arg Leu Pro Leu Ala Gln Val Ser Ala His Pro Trp 
    210                 215                 220                 


Val Arg Ala Asn Ser Arg Arg Val Leu Pro Pro Ser Ala Leu Gln Ser 
225                 230                 235                 240 


Val Ala 
        


<210> 3763
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<400> 3763
Met Pro Asp Xaa Met Leu Pro Ala Cys Phe Leu Gly Leu Leu Ala Phe 
1               5                   10                  15      


Ser Ser Ala Cys Tyr Phe Gln Asn Cys Pro Arg Gly Gly Lys Arg Ala 
            20                  25                  30          


Met Ser Asp Leu Glu Leu Arg Gln Cys Leu Pro Cys Gly Pro Gly Gly 
        35                  40                  45              


Lys Gly Arg Cys Phe Gly Pro Ser Ile Cys Cys Ala Asp Glu Leu Gly 
    50                  55                  60                  


Cys Phe Val Gly Xaa Ala Glu Ala Leu Arg Cys Gln Glu Glu Asn Tyr 
65                  70                  75                  80  


Leu Pro Ser Pro Cys Gln Ser Gly Gln Lys Ala Cys Gly Ser Gly Gly 
                85                  90                  95      


Arg Cys Ala Ala Phe Gly Val Cys Cys Asn Asp Glu Ser Cys Val Xaa 
            100                 105                 110         


Glu Pro Glu Cys Arg Glu Gly Phe His Arg Arg Ala Arg Ala Ser Asp 
        115                 120                 125             


Arg Ser Asn Ala Xaa Gln Leu Asp Gly Pro Ala Gly Ala Leu Leu Leu 
    130                 135                 140                 


Arg Leu Val Gln Leu Ala Gly Ala Pro Glu Pro Phe Glu Pro Ala Gln 
145                 150                 155                 160 


Pro Asp Ala Tyr 
                


<210> 3764
<211> 418
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<400> 3764
Met Arg Leu Ser Ala Gly Pro Asp Ala Gly Pro Ser Gly Asn Ser Ser 
1               5                   10                  15      


Pro Trp Trp Pro Leu Ala Xaa Gly Ala Gly Asn Xaa Ser Arg Glu Ala 
            20                  25                  30          


Glu Ala Leu Gly Glu Gly Asn Gly Pro Pro Arg Asp Val Arg Asn Glu 
        35                  40                  45              


Glu Leu Ala Lys Leu Glu Ile Ala Val Leu Ala Val Xaa Phe Ala Val 
    50                  55                  60                  


Ala Val Leu Gly Asn Ser Ser Val Leu Leu Ala Leu His Arg Xaa Pro 
65                  70                  75                  80  


Arg Lys Xaa Ser Arg Met His Leu Phe Ile Arg His Leu Ser Leu Ala 
                85                  90                  95      


Asp Leu Ala Val Ala Phe Phe Gln Val Leu Pro Gln Met Cys Trp Asp 
            100                 105                 110         


Ile Xaa Tyr Arg Phe Arg Gly Pro Asp Trp Leu Cys Arg Val Val Lys 
        115                 120                 125             


His Leu Gln Val Phe Gly Met Phe Ala Ser Ala Tyr Met Leu Val Val 
    130                 135                 140                 


Met Xaa Ala Asp Arg Tyr Ile Ala Val Cys His Pro Leu Lys Xaa Leu 
145                 150                 155                 160 


Gln Gln Pro Ala Arg Arg Ser Arg Leu Met Ile Ala Ala Ala Trp Val 
                165                 170                 175     


Leu Ser Phe Val Leu Ser Xaa Pro Gln Tyr Phe Val Phe Ser Met Ile 
            180                 185                 190         


Glu Val Asn Asn Val Xaa Lys Ala Arg Asp Cys Trp Ala Xaa Phe Ile 
        195                 200                 205             


Gln Pro Trp Gly Ser Arg Ala Tyr Val Xaa Trp Met Xaa Gly Gly Ile 
    210                 215                 220                 


Phe Val Ala Pro Val Val Ile Leu Gly Xaa Cys Tyr Gly Phe Ile Cys 
225                 230                 235                 240 


Tyr Asn Ile Trp Cys Asn Val Arg Gly Lys Xaa Ala Ser Arg Gln Ser 
                245                 250                 255     


Lys Gly Ala Glu Gln Ala Gly Val Ala Phe Gln Lys Gly Phe Leu Leu 
            260                 265                 270         


Ala Pro Cys Val Ser Ser Val Lys Ser Ile Ser Arg Ala Lys Ile Arg 
        275                 280                 285             


Xaa Val Lys Met Xaa Phe Val Ile Val Xaa Ala Tyr Ile Val Cys Trp 
    290                 295                 300                 


Ala Pro Phe Phe Ile Ile Gln Met Trp Ser Val Trp Asp Pro Met Ser 
305                 310                 315                 320 


Val Trp Xaa Glu Ser Glu Asn Pro Xaa Ile Xaa Ile Xaa Ala Leu Leu 
                325                 330                 335     


Gly Ser Leu Asn Ser Cys Cys Asn Pro Trp Ile Tyr Met Phe Phe Ser 
            340                 345                 350         


Gly His Leu Leu Gln Asp Cys Val Gln Ser Phe Pro Cys Cys Gln Asn 
        355                 360                 365             


Met Lys Glu Lys Phe Asn Lys Glu Asp Xaa Asp Ser Met Ser Arg Arg 
    370                 375                 380                 


Gln Xaa Phe Tyr Ser Asn Asn Arg Ser Pro Xaa Asn Ser Xaa Gly Met 
385                 390                 395                 400 


Trp Lys Asp Ser Pro Lys Ser Ser Lys Ser Ile Lys Phe Ile Pro Val 
                405                 410                 415     


Ser Xaa 
        


<210> 3765
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<400> 3765
Met Xaa Gly Gly Ile Phe Val Ala Pro Val Val Ile Leu Gly Xaa Cys 
1               5                   10                  15      


Tyr Gly Phe Ile Cys Tyr Asn Ile Trp Cys Asn Val Arg Gly Lys Xaa 
            20                  25                  30          


Ala Ser Arg Gln Ser Lys Gly Ala Glu Gln Ala Gly Val Ala Phe Gln 
        35                  40                  45              


Lys Gly Phe Leu Leu Ala Pro Cys Val Ser Ser Val Lys Ser Ile Ser 
    50                  55                  60                  


Arg Ala Lys Ile Arg Xaa Val Lys Met Xaa Phe Val Ile Val Xaa Ala 
65                  70                  75                  80  


Tyr Ile Val Cys Trp Ala Pro Phe Phe Ile Ile Gln Met Trp Ser Val 
                85                  90                  95      


Trp Asp Pro Met Ser Val Trp Xaa Glu Ser Glu Asn Pro Xaa Ile Xaa 
            100                 105                 110         


Ile Xaa Ala Leu Leu Gly Ser Leu Asn Ser Cys Cys Asn Pro Trp Ile 
        115                 120                 125             


Tyr Met Phe Phe Ser Gly His Leu Leu Gln Asp Cys Val Gln Ser Phe 
    130                 135                 140                 


Pro Cys Cys Gln Asn Met Lys Glu Lys Phe Asn Lys Glu Asp Xaa Asp 
145                 150                 155                 160 


Ser Met Ser Arg Arg Gln Xaa Phe Tyr Ser Asn Asn Arg Ser Pro Xaa 
                165                 170                 175     


Asn Ser Xaa Asp Lys Lys Met Arg Xaa Gly 
            180                 185     


<210> 3766
<211> 424
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<400> 3766
Met Asp Ser Gly Pro Leu Trp Asp Ala Asn Pro Xaa Pro Arg Gly Xaa 
1               5                   10                  15      


Leu Ser Ala Pro Asn Ala Xaa Xaa Pro Trp Leu Gly Arg Asp Glu Glu 
            20                  25                  30          


Leu Ala Lys Val Glu Ile Gly Val Leu Ala Xaa Val Leu Val Leu Ala 
        35                  40                  45              


Xaa Gly Gly Asn Leu Ala Val Leu Leu Xaa Leu Gly Gln Leu Gly Arg 
    50                  55                  60                  


Lys Arg Ser Arg Met His Leu Phe Val Leu His Leu Ala Leu Xaa Asp 
65                  70                  75                  80  


Leu Ala Val Ala Leu Phe Gln Val Leu Pro Gln Leu Leu Trp Asp Ile 
                85                  90                  95      


Xaa Tyr Arg Phe Gln Gly Pro Asp Leu Leu Cys Arg Ala Val Lys Tyr 
            100                 105                 110         


Leu Gln Val Leu Ser Met Phe Ala Ser Xaa Tyr Met Leu Leu Ala Met 
        115                 120                 125             


Xaa Leu Asp Arg Tyr Leu Ala Val Cys His Pro Leu Arg Ser Leu Gln 
    130                 135                 140                 


Gln Pro Gly Gln Ser Xaa Tyr Leu Leu Ile Ala Ala Pro Trp Leu Leu 
145                 150                 155                 160 


Ala Ala Ile Phe Ser Leu Pro Gln Val Phe Ile Phe Ser Leu Arg Glu 
                165                 170                 175     


Val Ile Gln Gly Ser Gly Val Leu Asp Cys Trp Ala Asp Phe Gly Phe 
            180                 185                 190         


Pro Trp Gly Pro Arg Ala Tyr Leu Xaa Trp Xaa Xaa Leu Ala Ile Phe 
        195                 200                 205             


Val Leu Pro Val Xaa Met Leu Xaa Ala Cys Tyr Ser Leu Ile Cys His 
    210                 215                 220                 


Glu Ile Cys Lys Asn Leu Lys Val Lys Xaa Gln Ala Trp Arg Val Gly 
225                 230                 235                 240 


Gly Gly Gly Trp Arg Xaa Trp Asp Arg Pro Ser Pro Ser Xaa Leu Ala 
                245                 250                 255     


Ala Xaa Xaa Arg Gly Leu Pro Ser Arg Val Ser Ser Ile Asn Xaa Ile 
            260                 265                 270         


Ser Arg Ala Lys Ile Arg Xaa Val Lys Met Xaa Phe Val Ile Val Leu 
        275                 280                 285             


Ala Tyr Ile Ala Cys Trp Ala Pro Phe Phe Ser Val Gln Met Trp Ser 
    290                 295                 300                 


Val Trp Asp Lys Asn Ala Pro Asp Glu Asp Ser Xaa Asn Val Ala Phe 
305                 310                 315                 320 


Xaa Ile Ser Met Leu Leu Gly Asn Leu Asn Ser Cys Cys Asn Pro Trp 
                325                 330                 335     


Ile Tyr Met Gly Phe Asn Ser His Leu Leu Pro Arg Pro Leu Arg His 
            340                 345                 350         


Leu Ala Cys Cys Gly Gly Pro Gln Pro Arg Met Arg Arg Arg Leu Ser 
        355                 360                 365             


Asp Gly Ser Leu Ser Ser Arg His Xaa Xaa Leu Leu Xaa Arg Ser Ser 
    370                 375                 380                 


Cys Pro Ala Xaa Leu Ser Leu Ser Leu Ser Leu Xaa Leu Ser Gly Arg 
385                 390                 395                 400 


Pro Arg Pro Glu Glu Ser Pro Arg Asp Leu Glu Leu Ala Asp Gly Glu 
                405                 410                 415     


Gly Xaa Ala Glu Xaa Ile Ile Phe 
            420                 


<210> 3767
<211> 48
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<400> 3767
Met Leu Met Ala Ser Xaa Xaa Ser Ala Cys Pro Ser Ser Ser Ser Ser 
1               5                   10                  15      


Pro Ser Ala Xaa Trp Lys Val Ala Ala Gly Ser Leu Xaa Ala Gly Pro 
            20                  25                  30          


Ala Leu Arg Ser Pro Gly Ala Val Ala Pro Met Ser Pro Gly Leu Pro 
        35                  40                  45              


<210> 3768
<211> 309
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<400> 3768
Met Leu Met Ala Ser Xaa Xaa Ser Ala Val Pro Gly His Pro Ser Leu 
1               5                   10                  15      


Pro Ser Leu Pro Ser Asn Ser Ser Gln Glu Arg Pro Leu Asp Xaa Arg 
            20                  25                  30          


Asp Pro Leu Leu Ala Arg Ala Glu Leu Ala Leu Leu Ser Ile Val Phe 
        35                  40                  45              


Val Ala Val Ala Leu Ser Asn Gly Leu Val Leu Ala Ala Leu Ala Arg 
    50                  55                  60                  


Arg Gly Arg Arg Gly His Trp Ala Pro Ile His Val Phe Ile Gly His 
65                  70                  75                  80  


Leu Cys Leu Ala Asp Leu Ala Val Ala Leu Phe Gln Val Leu Pro Gln 
                85                  90                  95      


Leu Ala Trp Lys Ala Xaa Asp Arg Phe Arg Gly Pro Asp Ala Leu Cys 
            100                 105                 110         


Arg Ala Val Lys Tyr Leu Gln Met Val Gly Met Tyr Ala Ser Ser Tyr 
        115                 120                 125             


Met Ile Leu Ala Met Xaa Leu Asp Arg His Arg Ala Ile Cys Arg Pro 
    130                 135                 140                 


Met Leu Ala Tyr Arg His Gly Ser Gly Ala His Trp Asn Arg Pro Val 
145                 150                 155                 160 


Leu Val Ala Trp Ala Phe Ser Leu Leu Leu Ser Leu Pro Gln Leu Phe 
                165                 170                 175     


Ile Phe Ala Gln Arg Asn Val Glu Gly Gly Ser Gly Val Xaa Asp Cys 
            180                 185                 190         


Trp Ala Cys Phe Ala Glu Pro Trp Gly Arg Arg Xaa Tyr Val Xaa Trp 
        195                 200                 205             


Ile Ala Leu Met Val Phe Val Ala Pro Xaa Leu Gly Ile Ala Ala Cys 
    210                 215                 220                 


Gln Val Leu Ile Phe Arg Glu Ile His Ala Ser Leu Val Pro Gly Pro 
225                 230                 235                 240 


Ser Glu Arg Pro Gly Gly Arg Arg Arg Gly Arg Arg Xaa Gly Ser Pro 
                245                 250                 255     


Gly Glu Gly Ala His Val Ser Ala Ala Val Ala Lys Xaa Val Arg Met 
            260                 265                 270         


Xaa Leu Val Ile Val Val Val Tyr Val Leu Cys Trp Ala Pro Phe Phe 
        275                 280                 285             


Leu Val Gln Leu Trp Ala Ala Trp Asp Pro Glu Ala Pro Leu Glu Gly 
    290                 295                 300                 


Gly Cys Ser Arg Gly 
305                 


<210> 3769
<211> 371
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<400> 3769
Met Leu Met Ala Ser Xaa Xaa Ser Ala Val Pro Gly His Pro Ser Leu 
1               5                   10                  15      


Pro Ser Leu Pro Ser Asn Ser Ser Gln Glu Arg Pro Leu Asp Xaa Arg 
            20                  25                  30          


Asp Pro Leu Leu Ala Arg Ala Glu Leu Ala Leu Leu Ser Ile Val Phe 
        35                  40                  45              


Val Ala Val Ala Leu Ser Asn Gly Leu Val Leu Ala Ala Leu Ala Arg 
    50                  55                  60                  


Arg Gly Arg Arg Gly His Trp Ala Pro Ile His Val Phe Ile Gly His 
65                  70                  75                  80  


Leu Cys Leu Ala Asp Leu Ala Val Ala Leu Phe Gln Val Leu Pro Gln 
                85                  90                  95      


Leu Ala Trp Lys Ala Xaa Asp Arg Phe Arg Gly Pro Asp Ala Leu Cys 
            100                 105                 110         


Arg Ala Val Lys Tyr Leu Gln Met Val Gly Met Tyr Ala Ser Ser Tyr 
        115                 120                 125             


Met Ile Leu Ala Met Xaa Leu Asp Arg His Arg Ala Ile Cys Arg Pro 
    130                 135                 140                 


Met Leu Ala Tyr Arg His Gly Ser Gly Ala His Trp Asn Arg Pro Val 
145                 150                 155                 160 


Leu Val Ala Trp Ala Phe Ser Leu Leu Leu Ser Leu Pro Gln Leu Phe 
                165                 170                 175     


Ile Phe Ala Gln Arg Asn Val Glu Gly Gly Ser Gly Val Xaa Asp Cys 
            180                 185                 190         


Trp Ala Cys Phe Ala Glu Pro Trp Gly Arg Arg Xaa Tyr Val Xaa Trp 
        195                 200                 205             


Ile Ala Leu Met Val Phe Val Ala Pro Xaa Leu Gly Ile Ala Ala Cys 
    210                 215                 220                 


Gln Val Leu Ile Phe Arg Glu Ile His Ala Ser Leu Val Pro Gly Pro 
225                 230                 235                 240 


Ser Glu Arg Pro Gly Gly Arg Arg Arg Gly Arg Arg Xaa Gly Ser Pro 
                245                 250                 255     


Gly Glu Gly Ala His Val Ser Ala Ala Val Ala Lys Xaa Val Arg Met 
            260                 265                 270         


Xaa Leu Val Ile Val Val Val Tyr Val Leu Cys Trp Ala Pro Phe Phe 
        275                 280                 285             


Leu Val Gln Leu Trp Ala Ala Trp Asp Pro Glu Ala Pro Leu Glu Gly 
    290                 295                 300                 


Ala Pro Phe Val Leu Leu Met Leu Leu Ala Ser Leu Asn Ser Cys Xaa 
305                 310                 315                 320 


Asn Pro Trp Ile Tyr Ala Ser Phe Ser Ser Ser Val Ser Ser Glu Leu 
                325                 330                 335     


Arg Ser Leu Leu Cys Cys Ala Arg Gly Arg Xaa Pro Pro Ser Leu Gly 
            340                 345                 350         


Pro Gln Asp Glu Ser Cys Xaa Xaa Ala Ser Ser Ser Leu Ala Lys Asp 
        355                 360                 365             


Xaa Ser Ser 
    370     


<210> 3770
<211> 372
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<400> 3770
Met Leu Met Ala Ser Xaa Xaa Ser Ala Val Pro Gly His Pro Ser Leu 
1               5                   10                  15      


Pro Ser Leu Pro Ser Asn Ser Ser Gln Glu Arg Pro Leu Asp Xaa Arg 
            20                  25                  30          


Asp Pro Leu Leu Ala Arg Ala Glu Leu Ala Leu Leu Ser Ile Val Phe 
        35                  40                  45              


Val Ala Val Ala Leu Ser Asn Gly Leu Val Leu Ala Ala Leu Ala Arg 
    50                  55                  60                  


Arg Gly Arg Arg Gly His Trp Ala Pro Ile His Val Phe Ile Gly His 
65                  70                  75                  80  


Leu Cys Leu Ala Asp Leu Ala Val Ala Leu Phe Gln Val Leu Pro Gln 
                85                  90                  95      


Leu Ala Trp Lys Ala Xaa Asp Arg Phe Arg Gly Pro Asp Ala Leu Cys 
            100                 105                 110         


Arg Ala Val Lys Tyr Leu Gln Met Val Gly Met Tyr Ala Ser Ser Tyr 
        115                 120                 125             


Met Ile Leu Ala Met Xaa Leu Asp Arg His Arg Ala Ile Cys Arg Pro 
    130                 135                 140                 


Met Leu Ala Tyr Arg His Gly Ser Gly Ala His Trp Asn Arg Pro Val 
145                 150                 155                 160 


Leu Val Ala Trp Ala Phe Ser Leu Leu Leu Ser Leu Pro Gln Leu Phe 
                165                 170                 175     


Ile Phe Ala Gln Arg Asn Val Glu Gly Gly Ser Gly Val Xaa Asp Cys 
            180                 185                 190         


Trp Ala Cys Phe Ala Glu Pro Trp Gly Arg Arg Xaa Tyr Val Xaa Trp 
        195                 200                 205             


Ile Ala Leu Met Val Phe Val Ala Pro Xaa Leu Gly Ile Ala Ala Cys 
    210                 215                 220                 


Gln Val Leu Ile Phe Arg Glu Ile His Ala Ser Leu Val Pro Gly Pro 
225                 230                 235                 240 


Ser Glu Arg Pro Gly Gly Arg Arg Arg Gly Arg Arg Xaa Gly Ser Pro 
                245                 250                 255     


Gly Glu Gly Ala His Val Ser Ala Ala Val Ala Lys Xaa Val Arg Met 
            260                 265                 270         


Xaa Leu Gly Arg Pro Leu Cys Tyr Ser Cys Cys Trp Pro Ala Ser Xaa 
        275                 280                 285             


Ala Ala Pro Xaa Pro Gly Ser Met His Leu Ser Ala Ala Ala Cys Pro 
    290                 295                 300                 


Gln Ser Cys Glu Ala Cys Ser Ala Val Pro Gly Asp Ala Pro His Pro 
305                 310                 315                 320 


Ala Trp Val Pro Lys Met Ser Pro Ala Pro Pro Pro Ala Pro Pro Trp 
                325                 330                 335     


Pro Arg Xaa Leu His Arg Glu Glu Leu Leu Gly Val Leu Pro Leu Glu 
            340                 345                 350         


Ala Leu Arg Ser Ser Ala Ala Phe Leu Gly Leu Val Leu Gly Ala Xaa 
        355                 360                 365             


Gly Arg Gly Xaa 
    370         


<210> 3771
<211> 826
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<400> 3771
Met Asn Ile Gln Glu Gln Gly Phe Pro Leu Asp Leu Gly Ala Ser Phe 
1               5                   10                  15      


Xaa Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu Leu 
            20                  25                  30          


Val Ser Xaa Asp Pro Arg Pro Ala Ser Tyr Ser Phe Cys Ser Gly Lys 
        35                  40                  45              


Gly Val Gly Ile Lys Gly Glu Xaa Ser Xaa Ala Xaa Pro Arg Arg Ser 
    50                  55                  60                  


Asp Leu Asp Leu Gly Tyr Glu Pro Glu Gly Ser Ala Ser Pro Xaa Pro 
65                  70                  75                  80  


Pro Tyr Leu Lys Trp Ala Glu Ser Leu His Ser Leu Leu Asp Asp Gln 
                85                  90                  95      


Asp Gly Ile Ser Leu Phe Arg Xaa Phe Leu Lys Gln Glu Gly Cys Ala 
            100                 105                 110         


Asp Leu Leu Asp Phe Trp Phe Ala Cys Xaa Gly Phe Arg Lys Leu Glu 
        115                 120                 125             


Pro Cys Asp Ser Asn Glu Glu Lys Arg Leu Lys Leu Ala Arg Ala Ile 
    130                 135                 140                 


Tyr Arg Lys Tyr Ile Leu Asp Asn Asn Gly Ile Val Ser Arg Gln Xaa 
145                 150                 155                 160 


Lys Pro Ala Xaa Lys Ser Phe Ile Lys Gly Cys Ile Met Lys Gln Leu 
                165                 170                 175     


Ile Asp Pro Ala Met Phe Asp Gln Ala Gln Xaa Glu Ile Gln Ala Xaa 
            180                 185                 190         


Met Glu Glu Asn Xaa Tyr Pro Ser Phe Leu Lys Ser Asp Ile Tyr Leu 
        195                 200                 205             


Glu Tyr Xaa Arg Xaa Gly Ser Glu Ser Pro Lys Val Cys Ser Asp Gln 
    210                 215                 220                 


Ser Ser Gly Ser Gly Xaa Gly Lys Gly Ile Ser Gly Tyr Leu Pro Xaa 
225                 230                 235                 240 


Leu Asn Glu Asp Glu Glu Trp Lys Cys Asp Gln Asp Met Asp Glu Asp 
                245                 250                 255     


Asp Gly Arg Asp Ala Ala Pro Pro Gly Arg Leu Pro Gln Lys Leu Leu 
            260                 265                 270         


Leu Glu Xaa Ala Ala Pro Arg Val Ser Ser Ser Arg Arg Tyr Ser Glu 
        275                 280                 285             


Gly Arg Glu Phe Arg Tyr Gly Ser Trp Arg Glu Pro Val Asn Pro Tyr 
    290                 295                 300                 


Tyr Val Asn Ala Gly Tyr Ala Leu Ala Pro Ala Xaa Ser Ala Asn Asp 
305                 310                 315                 320 


Ser Glu Gln Gln Ser Leu Ser Ser Asp Ala Asp Xaa Leu Ser Leu Xaa 
                325                 330                 335     


Asp Ser Ser Val Asp Gly Ile Pro Pro Tyr Arg Ile Arg Lys Gln His 
            340                 345                 350         


Arg Arg Glu Met Gln Glu Ser Val Gln Val Asn Gly Arg Val Pro Leu 
        355                 360                 365             


Pro His Ile Pro Arg Xaa Tyr Arg Val Pro Lys Glu Val Arg Val Glu 
    370                 375                 380                 


Pro Gln Lys Phe Ala Glu Glu Leu Ile His Arg Leu Glu Ala Val Gln 
385                 390                 395                 400 


Arg Xaa Arg Glu Ala Glu Glu Lys Leu Glu Glu Arg Leu Lys Arg Val 
                405                 410                 415     


Arg Met Glu Glu Glu Gly Glu Asp Gly Asp Pro Ser Ser Gly Pro Pro 
            420                 425                 430         


Gly Pro Cys His Lys Leu Pro Pro Ala Pro Ala Trp His His Phe Pro 
        435                 440                 445             


Pro Arg Cys Val Asp Met Gly Cys Ala Gly Leu Arg Asp Ala His Glu 
    450                 455                 460                 


Glu Asn Pro Glu Ser Ile Leu Asp Glu His Val Gln Arg Val Leu Arg 
465                 470                 475                 480 


Xaa Pro Gly Arg Gln Ser Pro Gly Pro Gly His Arg Ser Pro Asp Ser 
                485                 490                 495     


Gly His Val Ala Lys Met Pro Val Ala Leu Gly Gly Ala Ala Ser Gly 
            500                 505                 510         


His Gly Lys His Val Pro Lys Ser Gly Ala Lys Leu Asp Ala Ala Gly 
        515                 520                 525             


Leu His His His Arg His Val His His His Val His His Ser Xaa Ala 
    530                 535                 540                 


Arg Pro Lys Glu Gln Val Glu Ala Glu Ala Xaa Arg Arg Ala Gln Ser 
545                 550                 555                 560 


Ser Phe Ala Trp Gly Leu Glu Pro His Ser His Gly Ala Arg Ser Arg 
                565                 570                 575     


Gly Tyr Ser Glu Ser Val Gly Ala Ala Pro Asn Ala Ser Asp Gly Leu 
            580                 585                 590         


Ala His Ser Gly Lys Val Gly Val Ala Cys Lys Arg Asn Ala Lys Lys 
        595                 600                 605             


Ala Glu Ser Gly Lys Ser Ala Ser Xaa Glu Val Pro Gly Ala Ser Glu 
    610                 615                 620                 


Asp Ala Glu Lys Asn Gln Lys Ile Met Gln Trp Ile Ile Glu Gly Glu 
625                 630                 635                 640 


Lys Glu Ile Ser Arg His Arg Arg Xaa Gly His Gly Ser Ser Gly Xaa 
                645                 650                 655     


Arg Lys Pro Gln Pro His Glu Asn Ser Arg Pro Leu Ser Leu Glu His 
            660                 665                 670         


Pro Trp Ala Gly Pro Gln Leu Arg Xaa Ser Val Gln Pro Ser His Leu 
        675                 680                 685             


Phe Ile Gln Asp Pro Xaa Met Pro Pro His Pro Ala Pro Asn Pro Leu 
    690                 695                 700                 


Xaa Gln Leu Glu Glu Ala Arg Arg Arg Leu Glu Glu Glu Glu Lys Arg 
705                 710                 715                 720 


Ala Ser Arg Ala Pro Ser Lys Gln Arg Xaa Arg Ser Gln Arg Lys Val 
                725                 730                 735     


Gly Gly Gly Ser Ala Gln Pro Cys Asp Ser Ile Val Val Ala Tyr Tyr 
            740                 745                 750         


Phe Cys Gly Glu Pro Ile Pro Tyr Arg Xaa Leu Val Arg Gly Arg Ala 
        755                 760                 765             


Val Xaa Leu Gly Gln Phe Lys Glu Leu Leu Xaa Lys Lys Gly Ser Tyr 
    770                 775                 780                 


Arg Tyr Tyr Phe Lys Lys Val Ser Asp Glu Phe Asp Cys Gly Val Val 
785                 790                 795                 800 


Phe Glu Glu Val Arg Glu Asp Glu Ala Val Leu Pro Val Phe Glu Glu 
                805                 810                 815     


Lys Ile Ile Gly Lys Val Glu Lys Val Asp 
            820                 825     


<210> 3772
<211> 862
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<400> 3772
Met Asn Ile Gln Glu Gln Gly Phe Pro Leu Asp Leu Gly Ala Ser Phe 
1               5                   10                  15      


Xaa Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu Leu 
            20                  25                  30          


Val Ser Xaa Asp Pro Arg Pro Ala Ser Tyr Ser Phe Cys Ser Gly Lys 
        35                  40                  45              


Gly Val Gly Ile Lys Gly Glu Xaa Ser Xaa Ala Xaa Pro Arg Arg Ser 
    50                  55                  60                  


Asp Leu Asp Leu Gly Tyr Glu Pro Glu Gly Ser Ala Ser Pro Xaa Pro 
65                  70                  75                  80  


Pro Tyr Leu Lys Trp Ala Glu Ser Leu His Ser Leu Leu Asp Asp Gln 
                85                  90                  95      


Asp Gly Ile Ser Leu Phe Arg Xaa Phe Leu Lys Gln Glu Gly Cys Ala 
            100                 105                 110         


Asp Leu Leu Asp Phe Trp Phe Ala Cys Xaa Gly Phe Arg Lys Leu Glu 
        115                 120                 125             


Pro Cys Asp Ser Asn Glu Glu Lys Arg Leu Lys Leu Ala Arg Ala Ile 
    130                 135                 140                 


Tyr Arg Lys Tyr Ile Leu Asp Asn Asn Gly Ile Val Ser Arg Gln Xaa 
145                 150                 155                 160 


Lys Pro Ala Xaa Lys Ser Phe Ile Lys Gly Cys Ile Met Lys Gln Leu 
                165                 170                 175     


Ile Asp Pro Ala Met Phe Asp Gln Ala Gln Xaa Glu Ile Gln Ala Xaa 
            180                 185                 190         


Met Glu Glu Asn Xaa Tyr Pro Ser Phe Leu Lys Ser Asp Ile Tyr Leu 
        195                 200                 205             


Glu Tyr Xaa Arg Xaa Gly Ser Glu Ser Pro Lys Val Cys Ser Asp Gln 
    210                 215                 220                 


Ser Ser Gly Ser Gly Xaa Gly Lys Gly Ile Ser Gly Tyr Leu Pro Xaa 
225                 230                 235                 240 


Leu Asn Glu Asp Glu Glu Trp Lys Cys Asp Gln Asp Met Asp Glu Asp 
                245                 250                 255     


Asp Gly Arg Asp Ala Ala Pro Pro Gly Arg Leu Pro Gln Lys Leu Leu 
            260                 265                 270         


Leu Glu Xaa Ala Ala Pro Arg Val Ser Ser Ser Arg Arg Tyr Ser Glu 
        275                 280                 285             


Gly Arg Glu Phe Arg Tyr Gly Ser Trp Arg Glu Pro Val Asn Pro Tyr 
    290                 295                 300                 


Tyr Val Asn Ala Gly Tyr Ala Leu Ala Pro Ala Xaa Ser Ala Asn Asp 
305                 310                 315                 320 


Ser Glu Gln Gln Ser Leu Ser Ser Asp Ala Asp Xaa Leu Ser Leu Xaa 
                325                 330                 335     


Asp Ser Ser Val Asp Gly Ile Pro Pro Tyr Arg Ile Arg Lys Gln His 
            340                 345                 350         


Arg Arg Glu Met Gln Glu Ser Val Gln Val Asn Gly Arg Val Pro Leu 
        355                 360                 365             


Pro His Ile Pro Arg Xaa Tyr Arg Val Pro Lys Glu Val Arg Val Glu 
    370                 375                 380                 


Pro Gln Lys Phe Ala Glu Glu Leu Ile His Arg Leu Glu Ala Val Gln 
385                 390                 395                 400 


Arg Xaa Arg Glu Ala Glu Glu Lys Leu Glu Glu Arg Leu Lys Arg Val 
                405                 410                 415     


Arg Met Glu Glu Glu Gly Glu Asp Gly Asp Pro Ser Ser Gly Pro Pro 
            420                 425                 430         


Gly Pro Cys His Lys Leu Pro Pro Ala Pro Ala Trp His His Phe Pro 
        435                 440                 445             


Pro Arg Cys Val Asp Met Gly Cys Ala Gly Leu Arg Asp Ala His Glu 
    450                 455                 460                 


Glu Asn Pro Glu Ser Ile Leu Asp Glu His Val Gln Arg Val Leu Arg 
465                 470                 475                 480 


Xaa Pro Gly Arg Gln Ser Pro Gly Pro Gly His Arg Ser Pro Asp Ser 
                485                 490                 495     


Gly His Val Ala Lys Met Pro Val Ala Leu Gly Gly Ala Ala Ser Gly 
            500                 505                 510         


His Gly Lys His Val Pro Lys Ser Gly Ala Lys Leu Asp Ala Ala Gly 
        515                 520                 525             


Leu His His His Arg His Val His His His Val His His Ser Xaa Ala 
    530                 535                 540                 


Arg Pro Lys Glu Gln Val Glu Ala Glu Ala Xaa Arg Arg Ala Gln Ser 
545                 550                 555                 560 


Ser Phe Ala Trp Gly Leu Glu Pro His Ser His Gly Ala Arg Ser Arg 
                565                 570                 575     


Gly Tyr Ser Glu Ser Val Gly Ala Ala Pro Asn Ala Ser Asp Gly Leu 
            580                 585                 590         


Ala His Ser Gly Lys Val Gly Val Ala Cys Lys Arg Asn Ala Lys Lys 
        595                 600                 605             


Ala Glu Ser Gly Lys Ser Ala Ser Xaa Glu Val Pro Gly Ala Ser Glu 
    610                 615                 620                 


Asp Ala Glu Lys Asn Gln Lys Ile Met Gln Trp Ile Ile Glu Gly Glu 
625                 630                 635                 640 


Lys Glu Ile Ser Arg His Arg Arg Xaa Gly His Gly Ser Ser Gly Xaa 
                645                 650                 655     


Arg Lys Pro Gln Pro His Glu Asn Ser Arg Pro Leu Ser Leu Glu His 
            660                 665                 670         


Pro Trp Ala Gly Pro Gln Leu Arg Xaa Ser Val Gln Pro Ser His Leu 
        675                 680                 685             


Phe Ile Gln Asp Pro Xaa Met Pro Pro His Pro Ala Pro Asn Pro Leu 
    690                 695                 700                 


Xaa Gln Leu Glu Glu Ala Arg Arg Arg Leu Glu Glu Glu Glu Lys Arg 
705                 710                 715                 720 


Ala Ser Arg Ala Pro Ser Lys Gln Arg Tyr Val Gln Glu Val Met Arg 
                725                 730                 735     


Arg Gly Arg Ala Cys Val Arg Pro Ala Cys Ala Pro Val Leu His Val 
            740                 745                 750         


Val Pro Ala Val Ser Asp Met Glu Leu Ser Glu Xaa Glu Xaa Arg Ser 
        755                 760                 765             


Gln Arg Lys Val Gly Gly Gly Ser Ala Gln Pro Cys Asp Ser Ile Val 
    770                 775                 780                 


Val Ala Tyr Tyr Phe Cys Gly Glu Pro Ile Pro Tyr Arg Xaa Leu Val 
785                 790                 795                 800 


Arg Gly Arg Ala Val Xaa Leu Gly Gln Phe Lys Glu Leu Leu Xaa Lys 
                805                 810                 815     


Lys Gly Ser Tyr Arg Tyr Tyr Phe Lys Lys Val Ser Asp Glu Phe Asp 
            820                 825                 830         


Cys Gly Val Val Phe Glu Glu Val Arg Glu Asp Glu Ala Val Leu Pro 
        835                 840                 845             


Val Phe Glu Glu Lys Ile Ile Gly Lys Val Glu Lys Val Asp 
    850                 855                 860         


<210> 3773
<211> 102
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 3773
Xaa Leu Glu Glu Glu Glu Lys Arg Ala Ser Arg Ala Pro Ser Lys Gln 
1               5                   10                  15      


Arg Xaa Arg Ser Gln Arg Lys Val Gly Gly Gly Ser Ala Gln Pro Cys 
            20                  25                  30          


Asp Ser Ile Val Val Ala Tyr Tyr Phe Cys Gly Glu Pro Ile Pro Tyr 
        35                  40                  45              


Arg Xaa Leu Val Arg Gly Arg Ala Val Xaa Leu Gly Gln Phe Lys Glu 
    50                  55                  60                  


Leu Leu Xaa Lys Lys Gly Ser Tyr Arg Pro Pro Ser His Leu Arg Cys 
65                  70                  75                  80  


Cys Leu Leu Xaa Ala Leu Leu Xaa Ser Val Leu Gln Ile Leu Leu Gln 
                85                  90                  95      


Glu Ser Glu Arg Arg Val 
            100         


<210> 3774
<211> 151
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 3774
Met Ser Ser Ala Met Leu Val Xaa Cys Leu Pro Asp Pro Ser Ser Ser 
1               5                   10                  15      


Phe Arg Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu 
            20                  25                  30          


Xaa Pro Pro Cys Gln Pro Gly Val Gly Lys Gly Gln Val Xaa Lys Pro 
        35                  40                  45              


Met Pro Val Ser Ser Asn Xaa Arg Arg Asn Glu Asp Gly Leu Gly Glu 
    50                  55                  60                  


Pro Glu Gly Arg Ala Ser Pro Asp Ser Pro Leu Xaa Arg Trp Xaa Lys 
65                  70                  75                  80  


Ser Leu His Ser Leu Leu Gly Asp Gln Asp Gly Ala Tyr Leu Phe Arg 
                85                  90                  95      


Xaa Phe Leu Glu Arg Glu Lys Cys Val Asp Xaa Leu Asp Phe Trp Phe 
            100                 105                 110         


Ala Cys Asn Gly Phe Arg Gln Met Asn Leu Lys Asp Xaa Lys Xaa Leu 
        115                 120                 125             


Arg Val Ala Lys Ala Ile Tyr Lys Arg Tyr Ile Glu Asn Asn Ser Ile 
    130                 135                 140                 


Val Ser Lys Gln Leu Lys Pro 
145                 150     


<210> 3775
<211> 192
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<400> 3775
Met Ser Ser Ala Met Leu Val Xaa Cys Leu Pro Asp Pro Ser Ser Ser 
1               5                   10                  15      


Phe Arg Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu 
            20                  25                  30          


Xaa Pro Pro Cys Gln Pro Gly Val Gly Lys Gly Gln Val Xaa Lys Pro 
        35                  40                  45              


Met Pro Val Ser Ser Asn Xaa Arg Arg Asn Glu Asp Gly Leu Gly Glu 
    50                  55                  60                  


Pro Glu Gly Arg Ala Ser Pro Asp Ser Pro Leu Xaa Arg Trp Xaa Lys 
65                  70                  75                  80  


Ser Leu His Ser Leu Leu Gly Asp Gln Asp Gly Ala Tyr Leu Phe Arg 
                85                  90                  95      


Xaa Phe Leu Glu Arg Glu Lys Cys Val Asp Xaa Leu Asp Phe Trp Phe 
            100                 105                 110         


Ala Cys Asn Gly Phe Arg Gln Met Asn Leu Lys Asp Xaa Lys Xaa Leu 
        115                 120                 125             


Arg Val Ala Lys Ala Ile Tyr Lys Arg Tyr Ile Glu Asn Asn Ser Ile 
    130                 135                 140                 


Val Ser Lys Gln Leu Lys Pro Ala Xaa Lys Xaa Tyr Ile Arg Asp Gly 
145                 150                 155                 160 


Ile Lys Lys Gln Gln Ile Asp Ser Ile Met Phe Asp Gln Ala Gln Xaa 
                165                 170                 175     


Glu Ile Gln Ser Val Met Glu Glu Asn Ala Tyr Gln Met Phe Leu Xaa 
            180                 185                 190         


<210> 3776
<211> 271
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<400> 3776
Met Ser Ser Ala Met Leu Val Xaa Cys Leu Pro Asp Pro Ser Ser Ser 
1               5                   10                  15      


Phe Arg Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu 
            20                  25                  30          


Xaa Pro Pro Cys Gln Pro Gly Val Gly Lys Gly Gln Val Xaa Lys Pro 
        35                  40                  45              


Met Pro Val Ser Ser Asn Xaa Arg Arg Asn Glu Asp Gly Leu Gly Glu 
    50                  55                  60                  


Pro Glu Gly Arg Ala Ser Pro Asp Ser Pro Leu Xaa Arg Trp Xaa Lys 
65                  70                  75                  80  


Ser Leu His Ser Leu Leu Gly Asp Gln Asp Gly Ala Tyr Leu Phe Arg 
                85                  90                  95      


Xaa Phe Leu Glu Arg Glu Lys Cys Val Asp Xaa Leu Asp Phe Trp Phe 
            100                 105                 110         


Ala Cys Asn Gly Phe Arg Gln Met Asn Leu Lys Asp Xaa Lys Xaa Leu 
        115                 120                 125             


Arg Val Ala Lys Ala Ile Tyr Lys Arg Tyr Ile Glu Asn Asn Ser Ile 
    130                 135                 140                 


Val Ser Lys Gln Leu Lys Pro Ala Xaa Lys Xaa Tyr Ile Arg Asp Gly 
145                 150                 155                 160 


Ile Lys Lys Gln Gln Ile Asp Ser Ile Met Phe Asp Gln Ala Gln Xaa 
                165                 170                 175     


Glu Ile Gln Ser Val Met Glu Glu Asn Ala Tyr Gln Met Phe Leu Xaa 
            180                 185                 190         


Ser Asp Ile Tyr Leu Glu Tyr Val Arg Ser Gly Gly Glu Asn Xaa Ala 
        195                 200                 205             


Tyr Met Ser Asn Gly Gly Leu Gly Ser Leu Lys Val Val Cys Gly Tyr 
    210                 215                 220                 


Leu Pro Xaa Leu Asn Glu Glu Glu Glu Trp Xaa Cys Ala Asp Phe Lys 
225                 230                 235                 240 


Cys Lys Leu Ser Pro Xaa Val Val Gly Leu Ser Ser Lys Xaa Leu Arg 
                245                 250                 255     


Ala Xaa Ala Ser Val Arg Ser Xaa Glu Xaa Val Asp Ser Gly Tyr 
            260                 265                 270     


<210> 3777
<211> 778
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<400> 3777
Met Ser Ser Ala Met Leu Val Xaa Cys Leu Pro Asp Pro Ser Ser Ser 
1               5                   10                  15      


Phe Arg Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu 
            20                  25                  30          


Xaa Pro Pro Cys Gln Pro Gly Val Gly Lys Gly Gln Val Xaa Lys Pro 
        35                  40                  45              


Met Pro Val Ser Ser Asn Xaa Arg Arg Asn Glu Asp Gly Leu Gly Glu 
    50                  55                  60                  


Pro Glu Gly Arg Ala Ser Pro Asp Ser Pro Leu Xaa Arg Trp Xaa Lys 
65                  70                  75                  80  


Ser Leu His Ser Leu Leu Gly Asp Gln Asp Gly Ala Tyr Leu Phe Arg 
                85                  90                  95      


Xaa Phe Leu Glu Arg Glu Lys Cys Val Asp Xaa Leu Asp Phe Trp Phe 
            100                 105                 110         


Ala Cys Asn Gly Phe Arg Gln Met Asn Leu Lys Asp Xaa Lys Xaa Leu 
        115                 120                 125             


Arg Val Ala Lys Ala Ile Tyr Lys Arg Tyr Ile Glu Asn Asn Ser Ile 
    130                 135                 140                 


Val Ser Lys Gln Leu Lys Pro Ala Xaa Lys Xaa Tyr Ile Arg Asp Gly 
145                 150                 155                 160 


Ile Lys Lys Gln Gln Ile Asp Ser Ile Met Phe Asp Gln Ala Gln Xaa 
                165                 170                 175     


Glu Ile Gln Ser Val Met Glu Glu Asn Ala Tyr Gln Met Phe Leu Xaa 
            180                 185                 190         


Ser Asp Ile Tyr Leu Glu Tyr Val Arg Ser Gly Gly Glu Asn Xaa Ala 
        195                 200                 205             


Tyr Met Ser Asn Gly Gly Leu Gly Ser Leu Lys Val Val Cys Gly Tyr 
    210                 215                 220                 


Leu Pro Xaa Leu Asn Glu Glu Glu Glu Trp Xaa Cys Ala Asp Phe Lys 
225                 230                 235                 240 


Cys Lys Leu Ser Pro Xaa Val Val Gly Leu Ser Ser Lys Xaa Leu Arg 
                245                 250                 255     


Ala Xaa Ala Ser Val Arg Ser Xaa Glu Xaa Val Asp Ser Gly Tyr Arg 
            260                 265                 270         


Ser Phe Lys Arg Ser Asp Pro Val Asn Pro Tyr His Ile Gly Ser Gly 
        275                 280                 285             


Tyr Val Phe Ala Pro Ala Xaa Ser Ala Asn Asp Ser Glu Ile Ser Ser 
    290                 295                 300                 


Asp Ala Leu Xaa Asp Asp Ser Met Ser Met Xaa Asp Ser Ser Val Asp 
305                 310                 315                 320 


Gly Ile Pro Pro Tyr Arg Val Gly Ser Lys Lys Gln Leu Gln Arg Glu 
                325                 330                 335     


Met His Arg Ser Val Lys Ala Asn Gly Gln Val Ser Leu Pro His Phe 
            340                 345                 350         


Pro Arg Xaa His Arg Leu Pro Lys Glu Met Xaa Pro Val Glu Pro Ala 
        355                 360                 365             


Xaa Phe Ala Ala Glu Leu Ile Ser Arg Leu Glu Lys Leu Lys Leu Glu 
    370                 375                 380                 


Leu Glu Ser Arg His Ser Leu Glu Glu Arg Leu Gln Gln Ile Arg Glu 
385                 390                 395                 400 


Asp Glu Glu Arg Glu Gly Ser Glu Leu Xaa Leu Asn Ser Arg Glu Gly 
                405                 410                 415     


Ala Pro Xaa Gln His Pro Leu Ser Leu Leu Pro Ser Gly Ser Tyr Glu 
            420                 425                 430         


Glu Asp Pro Gln Xaa Ile Leu Asp Asp His Leu Ser Arg Val Leu Lys 
        435                 440                 445             


Xaa Pro Gly Cys Gln Ser Pro Gly Val Gly Arg Tyr Ser Pro Arg Ser 
    450                 455                 460                 


Arg Ser Pro Asp His His His His His His Ser Gln Tyr His Ser Leu 
465                 470                 475                 480 


Leu Pro Pro Gly Gly Lys Leu Pro Pro Ala Ala Ala Ser Pro Gly Ala 
                485                 490                 495     


Cys Pro Leu Leu Gly Gly Lys Gly Phe Val Xaa Lys Gln Xaa Xaa Lys 
            500                 505                 510         


His Val His His His Tyr Ile His His His Ala Val Pro Lys Xaa Lys 
        515                 520                 525             


Glu Glu Ile Glu Ala Glu Ala Xaa Gln Arg Val His Cys Phe Cys Pro 
    530                 535                 540                 


Gly Gly Ser Glu Tyr Tyr Cys Tyr Ser Lys Cys Lys Ser His Ser Lys 
545                 550                 555                 560 


Ala Pro Glu Xaa Met Pro Ser Glu Gln Phe Gly Ala Gln Ser Xaa Lys 
                565                 570                 575     


Lys Ala Tyr Pro Leu Glu Ser Ala Arg Ser Ser Pro Gly Glu Arg Ala 
            580                 585                 590         


Ser Arg His His Leu Trp Gly Gly Asn Ser Gly His Pro Arg Xaa Xaa 
        595                 600                 605             


Pro Arg Ala His Leu Phe Xaa Gln Asp Pro Ala Met Pro Pro Leu Xaa 
    610                 615                 620                 


Pro Pro Asn Xaa Leu Ala Gln Leu Glu Glu Ala Cys Arg Arg Leu Ala 
625                 630                 635                 640 


Glu Val Ser Lys Pro Pro Lys Gln Arg Cys Cys Val Ala Ser Gln Gln 
                645                 650                 655     


Arg Asp Arg Asn His Ser Ala Xaa Val Gln Xaa Gly Ala Xaa Pro Phe 
            660                 665                 670         


Ser Asn Pro Ser Leu Ala Pro Glu Asp His Lys Glu Pro Lys Lys Leu 
        675                 680                 685             


Ala Gly Val His Ala Leu Gln Ala Ser Glu Leu Val Val Xaa Tyr Phe 
    690                 695                 700                 


Phe Cys Gly Glu Glu Ile Pro Tyr Arg Arg Met Leu Lys Ala Gln Ser 
705                 710                 715                 720 


Leu Xaa Leu Gly His Phe Lys Glu Gln Leu Ser Lys Lys Gly Asn Tyr 
                725                 730                 735     


Arg Tyr Tyr Phe Lys Lys Ala Ser Asp Glu Phe Ala Cys Gly Ala Val 
            740                 745                 750         


Phe Glu Glu Ile Trp Glu Asp Glu Xaa Val Leu Pro Met Tyr Glu Gly 
        755                 760                 765             


Arg Ile Leu Gly Lys Val Glu Arg Ile Asp 
    770                 775             


<210> 3778
<211> 843
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<400> 3778
Met Ser Ser Ala Met Leu Val Xaa Cys Leu Pro Asp Pro Ser Ser Ser 
1               5                   10                  15      


Phe Arg Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu 
            20                  25                  30          


Xaa Pro Pro Cys Gln Pro Gly Val Gly Lys Gly Gln Val Xaa Lys Pro 
        35                  40                  45              


Met Pro Val Ser Ser Asn Xaa Arg Arg Asn Glu Asp Gly Leu Gly Glu 
    50                  55                  60                  


Pro Glu Gly Arg Ala Ser Pro Asp Ser Pro Leu Xaa Arg Trp Xaa Lys 
65                  70                  75                  80  


Ser Leu His Ser Leu Leu Gly Asp Gln Asp Gly Ala Tyr Leu Phe Arg 
                85                  90                  95      


Xaa Phe Leu Glu Arg Glu Lys Cys Val Asp Xaa Leu Asp Phe Trp Phe 
            100                 105                 110         


Ala Cys Asn Gly Phe Arg Gln Met Asn Leu Lys Asp Xaa Lys Xaa Leu 
        115                 120                 125             


Arg Val Ala Lys Ala Ile Tyr Lys Arg Tyr Ile Glu Asn Asn Ser Ile 
    130                 135                 140                 


Val Ser Lys Gln Leu Lys Pro Ala Xaa Lys Xaa Tyr Ile Arg Asp Gly 
145                 150                 155                 160 


Ile Lys Lys Gln Gln Ile Asp Ser Ile Met Phe Asp Gln Ala Gln Xaa 
                165                 170                 175     


Glu Ile Gln Ser Val Met Glu Glu Asn Ala Tyr Gln Met Phe Leu Xaa 
            180                 185                 190         


Ser Asp Ile Tyr Leu Glu Tyr Val Arg Ser Gly Gly Glu Asn Xaa Ala 
        195                 200                 205             


Tyr Met Ser Asn Gly Gly Leu Gly Ser Leu Lys Val Val Cys Gly Tyr 
    210                 215                 220                 


Leu Pro Xaa Leu Asn Glu Glu Glu Glu Trp Xaa Cys Ala Asp Phe Lys 
225                 230                 235                 240 


Cys Lys Leu Ser Pro Xaa Val Val Gly Leu Ser Ser Lys Xaa Leu Arg 
                245                 250                 255     


Ala Xaa Ala Ser Val Arg Ser Xaa Glu Xaa Val Asp Ser Gly Tyr Arg 
            260                 265                 270         


Ser Phe Lys Arg Ser Asp Pro Val Asn Pro Tyr His Ile Gly Ser Gly 
        275                 280                 285             


Tyr Val Phe Ala Pro Ala Xaa Ser Ala Asn Asp Ser Glu Ile Ser Ser 
    290                 295                 300                 


Asp Ala Leu Xaa Asp Asp Ser Met Ser Met Xaa Asp Ser Ser Val Asp 
305                 310                 315                 320 


Gly Ile Pro Pro Tyr Arg Val Gly Ser Lys Lys Gln Leu Gln Arg Glu 
                325                 330                 335     


Met His Arg Ser Val Lys Ala Asn Gly Gln Val Ser Leu Pro His Phe 
            340                 345                 350         


Pro Arg Xaa His Arg Leu Pro Lys Glu Met Xaa Pro Val Glu Pro Ala 
        355                 360                 365             


Xaa Phe Ala Ala Glu Leu Ile Ser Arg Leu Glu Lys Leu Lys Leu Glu 
    370                 375                 380                 


Leu Glu Ser Arg His Ser Leu Glu Glu Arg Leu Gln Gln Ile Arg Glu 
385                 390                 395                 400 


Asp Glu Glu Arg Glu Gly Ser Glu Leu Xaa Leu Asn Ser Arg Glu Gly 
                405                 410                 415     


Ala Pro Xaa Gln His Pro Leu Ser Leu Leu Pro Ser Gly Ser Tyr Glu 
            420                 425                 430         


Glu Asp Pro Gln Xaa Ile Leu Asp Asp His Leu Ser Arg Val Leu Lys 
        435                 440                 445             


Xaa Pro Gly Cys Gln Ser Pro Gly Val Gly Arg Tyr Ser Pro Arg Ser 
    450                 455                 460                 


Arg Ser Pro Asp His His His His His His Ser Gln Tyr His Ser Leu 
465                 470                 475                 480 


Leu Pro Pro Gly Gly Lys Leu Pro Pro Ala Ala Ala Ser Pro Gly Ala 
                485                 490                 495     


Cys Pro Leu Leu Gly Gly Lys Gly Phe Val Xaa Lys Gln Xaa Xaa Lys 
            500                 505                 510         


His Val His His His Tyr Ile His His His Ala Val Pro Lys Xaa Lys 
        515                 520                 525             


Glu Glu Ile Glu Ala Glu Ala Xaa Gln Arg Val His Cys Phe Cys Pro 
    530                 535                 540                 


Gly Gly Ser Glu Tyr Tyr Cys Tyr Ser Lys Cys Lys Ser His Ser Lys 
545                 550                 555                 560 


Ala Pro Glu Xaa Met Pro Ser Glu Gln Phe Gly Gly Ser Arg Gly Ser 
                565                 570                 575     


Xaa Leu Pro Lys Arg Asn Gly Lys Gly Xaa Glu Pro Gly Leu Ala Leu 
            580                 585                 590         


Pro Ala Arg Glu Gly Gly Ala Pro Gly Gly Ala Gly Ala Leu Gln Leu 
        595                 600                 605             


Pro Arg Glu Glu Gly Asp Arg Ser Gln Asp Val Trp Gln Trp Met Leu 
    610                 615                 620                 


Glu Ser Glu Arg Gln Ser Lys Pro Lys Pro His Ser Ala Gln Ser Xaa 
625                 630                 635                 640 


Lys Lys Ala Tyr Pro Leu Glu Ser Ala Arg Ser Ser Pro Gly Glu Arg 
                645                 650                 655     


Ala Ser Arg His His Leu Trp Gly Gly Asn Ser Gly His Pro Arg Xaa 
            660                 665                 670         


Xaa Pro Arg Ala His Leu Phe Xaa Gln Asp Pro Ala Met Pro Pro Leu 
        675                 680                 685             


Xaa Pro Pro Asn Xaa Leu Ala Gln Leu Glu Glu Ala Cys Arg Arg Leu 
    690                 695                 700                 


Ala Glu Val Ser Lys Pro Pro Lys Gln Arg Cys Cys Val Ala Ser Gln 
705                 710                 715                 720 


Gln Arg Asp Arg Asn His Ser Ala Xaa Val Gln Xaa Gly Ala Xaa Pro 
                725                 730                 735     


Phe Ser Asn Pro Ser Leu Ala Pro Glu Asp His Lys Glu Pro Lys Lys 
            740                 745                 750         


Leu Ala Gly Val His Ala Leu Gln Ala Ser Glu Leu Val Val Xaa Tyr 
        755                 760                 765             


Phe Phe Cys Gly Glu Glu Ile Pro Tyr Arg Arg Met Leu Lys Ala Gln 
    770                 775                 780                 


Ser Leu Xaa Leu Gly His Phe Lys Glu Gln Leu Ser Lys Lys Gly Asn 
785                 790                 795                 800 


Tyr Arg Tyr Tyr Phe Lys Lys Ala Ser Asp Glu Phe Ala Cys Gly Ala 
                805                 810                 815     


Val Phe Glu Glu Ile Trp Glu Asp Glu Xaa Val Leu Pro Met Tyr Glu 
            820                 825                 830         


Gly Arg Ile Leu Gly Lys Val Glu Arg Ile Asp 
        835                 840             


<210> 3779
<211> 160
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 3779
Met Ser Ser Ala Met Leu Val Xaa Cys Leu Pro Asp Pro Ser Ser Ser 
1               5                   10                  15      


Phe Arg Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu 
            20                  25                  30          


Xaa Pro Pro Cys Gln Pro Gly Val Gly Lys Gly Gln Val Xaa Lys Pro 
        35                  40                  45              


Met Pro Val Ser Ser Asn Xaa Arg Arg Asn Glu Asp Gly Leu Gly Glu 
    50                  55                  60                  


Pro Glu Gly Arg Ala Ser Pro Asp Ser Pro Leu Xaa Arg Trp Xaa Lys 
65                  70                  75                  80  


Ser Leu His Ser Leu Leu Gly Asp Gln Asp Gly Ala Tyr Leu Phe Arg 
                85                  90                  95      


Xaa Phe Leu Glu Arg Glu Lys Cys Val Asp Xaa Leu Asp Phe Trp Phe 
            100                 105                 110         


Ala Cys Asn Gly Phe Arg Gln Met Asn Leu Lys Asp Xaa Lys Xaa Leu 
        115                 120                 125             


Arg Val Ala Lys Asp Phe Cys His Asp Ile Leu Phe Tyr Leu Tyr Cys 
    130                 135                 140                 


Lys Leu Cys Ile Ile Lys Ser Ser Phe Lys Glu Asn Tyr Leu Val Gln 
145                 150                 155                 160 


<210> 3780
<211> 885
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(864)
<223> Selenocysteine

<400> 3780
Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Xaa Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Xaa Gly Ala Arg 
        35                  40                  45              


Gly Leu Xaa Gly Xaa Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Xaa Gln Xaa Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Xaa Ser Leu Gln Leu Ser Asp Xaa 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Xaa Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Xaa Val Ala Ala Asn Xaa Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Xaa Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Xaa Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Xaa Xaa Ser Arg Xaa Ala Xaa Ile Xaa Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Xaa Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Xaa Pro Gly Leu Ser Gly Ile Tyr Pro Leu Xaa 
                245                 250                 255     


His Cys Xaa Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Xaa Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Xaa Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Xaa Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Xaa His Trp Leu Pro Val Glu Xaa Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Xaa Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Xaa Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Xaa Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Xaa Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Xaa Val Cys Val Ala Ala Tyr Xaa Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Val Lys Glu Pro 
            420                 425                 430         


Ser Xaa Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala 
        435                 440                 445             


Val Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu Val His 
    450                 455                 460                 


Arg Arg Lys Lys Glu Xaa Arg Tyr Gly Glu Val Phe Glu Pro Xaa Val 
465                 470                 475                 480 


Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser 
                485                 490                 495     


Arg Arg Xaa Xaa Glu Ala Xaa Leu Asn Ser Leu Gly Ile Ser Glu Glu 
            500                 505                 510         


Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala 
        515                 520                 525             


Leu Gly Lys Xaa Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly 
    530                 535                 540                 


Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Xaa Met 
545                 550                 555                 560 


Lys Ile Ala Ile Cys Xaa Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu 
                565                 570                 575     


Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile 
            580                 585                 590         


Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val 
        595                 600                 605             


Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu 
    610                 615                 620                 


Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Xaa Gln Met Leu 
625                 630                 635                 640 


Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Xaa 
                645                 650                 655     


Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn 
            660                 665                 670         


Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile 
        675                 680                 685             


Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val 
    690                 695                 700                 


Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Xaa Ser Lys 
705                 710                 715                 720 


Ser Asp Val Trp Ser Phe Gly Val Xaa Met Trp Glu Ile Ala Xaa Arg 
                725                 730                 735     


Gly Gln Xaa Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr 
            740                 745                 750         


Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly 
        755                 760                 765             


Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg 
    770                 775                 780                 


Pro Ser Phe Xaa Glu Leu Arg Glu Asp Leu Glu Asn Xaa Leu Lys Ala 
785                 790                 795                 800 


Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp 
                805                 810                 815     


Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp 
            820                 825                 830         


Pro Pro Xaa Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Xaa Ala 
        835                 840                 845             


Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Xaa Xaa 
    850                 855                 860                 


Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly 
865                 870                 875                 880 


Gln Glu Asp Gly Ala 
                885 


<210> 3781
<211> 894
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(873)
<223> Selenocysteine

<400> 3781
Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Xaa Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Xaa Gly Ala Arg 
        35                  40                  45              


Gly Leu Xaa Gly Xaa Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Xaa Gln Xaa Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Xaa Ser Leu Gln Leu Ser Asp Xaa 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Xaa Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Xaa Val Ala Ala Asn Xaa Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Xaa Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Xaa Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Xaa Xaa Ser Arg Xaa Ala Xaa Ile Xaa Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Xaa Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Xaa Pro Gly Leu Ser Gly Ile Tyr Pro Leu Xaa 
                245                 250                 255     


His Cys Xaa Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Xaa Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Xaa Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Xaa Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Xaa His Trp Leu Pro Val Glu Xaa Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Xaa Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Xaa Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Xaa Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Xaa Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Xaa Val Cys Val Ala Ala Tyr Xaa Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Xaa Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Xaa Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Xaa Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Xaa Xaa Glu Ala Xaa 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Xaa Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Xaa Met Lys Ile Ala Ile Cys Xaa Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Xaa Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Xaa Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Xaa Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Xaa Met Trp Glu Ile Ala Xaa Arg Gly Gln Xaa Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Xaa Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Xaa Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Xaa Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Xaa Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Xaa Xaa Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210> 3782
<211> 626
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(605)
<223> Selenocysteine

<400> 3782
Met Gly Ile Gln Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Xaa 
1               5                   10                  15      


Ser Gln Ala Ser Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His 
            20                  25                  30          


Pro His Xaa Pro Tyr His Ile Arg Val Ala Cys Xaa Ser Ser Gln Gly 
        35                  40                  45              


Pro Ser Ser Trp Xaa His Trp Leu Pro Val Glu Xaa Pro Glu Gly Val 
    50                  55                  60                  


Pro Leu Gly Pro Pro Glu Asn Ile Ser Ala Xaa Arg Asn Gly Ser Gln 
65                  70                  75                  80  


Ala Phe Val His Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Xaa Leu 
                85                  90                  95      


Leu Gly Tyr Arg Leu Ala Tyr Gln Gly Gln Asp Xaa Pro Glu Val Leu 
            100                 105                 110         


Met Asp Ile Gly Leu Arg Gln Glu Val Xaa Leu Glu Leu Gln Gly Asp 
        115                 120                 125             


Gly Ser Val Ser Asn Leu Xaa Val Cys Val Ala Ala Tyr Xaa Ala Ala 
    130                 135                 140                 


Gly Asp Gly Pro Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro 
145                 150                 155                 160 


Gly Gln Ala Gln Pro Val His Gln Leu Val Lys Glu Pro Ser Xaa Pro 
                165                 170                 175     


Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala 
            180                 185                 190         


Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys 
        195                 200                 205             


Lys Glu Xaa Arg Tyr Gly Glu Val Phe Glu Pro Xaa Val Glu Arg Gly 
    210                 215                 220                 


Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Xaa 
225                 230                 235                 240 


Xaa Glu Ala Xaa Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu 
                245                 250                 255     


Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys 
            260                 265                 270         


Xaa Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn 
        275                 280                 285             


Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Xaa Met Lys Ile Ala 
    290                 295                 300                 


Ile Cys Xaa Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys 
305                 310                 315                 320 


Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys 
                325                 330                 335     


Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu 
            340                 345                 350         


Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg 
        355                 360                 365             


Leu Gly Asp Gln Pro Val Tyr Leu Pro Xaa Gln Met Leu Val Lys Phe 
    370                 375                 380                 


Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Xaa Lys Arg Phe 
385                 390                 395                 400 


Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met 
                405                 410                 415     


Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly 
            420                 425                 430         


Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile 
        435                 440                 445             


Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Xaa Ser Lys Ser Asp Val 
    450                 455                 460                 


Trp Ser Phe Gly Val Xaa Met Trp Glu Ile Ala Xaa Arg Gly Gln Xaa 
465                 470                 475                 480 


Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln 
                485                 490                 495     


Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala 
            500                 505                 510         


Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe 
        515                 520                 525             


Xaa Glu Leu Arg Glu Asp Leu Glu Asn Xaa Leu Lys Ala Leu Pro Pro 
    530                 535                 540                 


Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly 
545                 550                 555                 560 


Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Xaa 
                565                 570                 575     


Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Xaa Ala Ala Glu Val 
            580                 585                 590         


His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Xaa Xaa Pro Ser Pro 
        595                 600                 605             


Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp 
    610                 615                 620                 


Gly Ala 
625     


<210> 3783
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 3783
Met Asp Ala Leu Val Glu Asp Asp Ile Cys Ile Leu Asn His Glu Lys 
1               5                   10                  15      


Ala His Lys Arg Asp Xaa Val Xaa Pro Val Ser Ile Tyr Ser Gly Asp 
            20                  25                  30          


Glu Ser Val Ala Ser His Phe Ala Leu Val Xaa Ala Tyr Glu Asp Ile 
        35                  40                  45              


Lys Lys Arg Leu Lys Asp Ser Glu Lys Glu Asn Ser Leu Leu Lys Lys 
    50                  55                  60                  


Arg Ile Arg Phe Leu Glu Glu Lys Leu Ile Ala Arg Phe Glu Glu Glu 
65                  70                  75                  80  


Xaa Ser Ser Val Gly Arg Glu Gln Val Asn Lys Ala Tyr His Ala 
                85                  90                  95  


<210> 3784
<211> 215
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<400> 3784
Met Asp Ala Leu Val Glu Asp Asp Ile Cys Ile Leu Asn His Glu Lys 
1               5                   10                  15      


Ala His Lys Arg Asp Xaa Val Xaa Pro Val Ser Ile Tyr Ser Gly Asp 
            20                  25                  30          


Glu Ser Val Ala Ser His Phe Ala Leu Val Xaa Ala Tyr Glu Asp Ile 
        35                  40                  45              


Lys Lys Arg Leu Lys Asp Ser Glu Lys Glu Asn Ser Leu Leu Lys Lys 
    50                  55                  60                  


Arg Ile Arg Phe Leu Glu Glu Lys Leu Ile Ala Arg Phe Glu Glu Glu 
65                  70                  75                  80  


Xaa Ser Ser Val Gly Arg Glu Gln Val Asn Lys Ala Tyr His Ala Tyr 
                85                  90                  95      


Arg Glu Val Cys Ile Asp Arg Asp Asn Leu Lys Ser Lys Leu Asp Lys 
            100                 105                 110         


Met Asn Lys Asp Asn Ser Glu Ser Leu Lys Val Leu Asn Glu Gln Leu 
        115                 120                 125             


Gln Ser Lys Glu Val Glu Leu Leu Gln Leu Arg Xaa Glu Val Glu Xaa 
    130                 135                 140                 


Gln Gln Val Met Arg Asn Leu Asn Pro Pro Ser Ser Asn Trp Glu Val 
145                 150                 155                 160 


Glu Lys Leu Ser Cys Asp Leu Lys Ile His Gly Leu Glu Gln Glu Leu 
                165                 170                 175     


Glu Leu Met Arg Lys Glu Cys Ser Asp Leu Lys Ile Glu Leu Gln Lys 
            180                 185                 190         


Ala Lys Gln Xaa Asp Pro Tyr Gln Glu Asp Asn Leu Lys Ser Arg Asp 
        195                 200                 205             


Leu Gln Lys Leu Ser Ile Ser 
    210                 215 


<210> 3785
<211> 243
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<400> 3785
Met Asp Ala Leu Val Glu Asp Asp Ile Cys Ile Leu Asn His Glu Lys 
1               5                   10                  15      


Ala His Lys Arg Asp Xaa Val Xaa Pro Val Ser Ile Tyr Ser Gly Asp 
            20                  25                  30          


Glu Ser Val Ala Ser His Phe Ala Leu Val Xaa Ala Tyr Glu Asp Ile 
        35                  40                  45              


Lys Lys Arg Leu Lys Asp Ser Glu Lys Glu Asn Ser Leu Leu Lys Lys 
    50                  55                  60                  


Arg Ile Arg Phe Leu Glu Glu Lys Leu Ile Ala Arg Phe Glu Glu Glu 
65                  70                  75                  80  


Xaa Ser Ser Val Gly Arg Glu Gln Val Asn Lys Ala Tyr His Ala Tyr 
                85                  90                  95      


Arg Glu Val Cys Ile Asp Arg Asp Asn Leu Lys Ser Lys Leu Asp Lys 
            100                 105                 110         


Met Asn Lys Asp Asn Ser Glu Ser Leu Lys Val Leu Asn Glu Gln Leu 
        115                 120                 125             


Gln Ser Lys Glu Val Glu Leu Leu Gln Leu Arg Xaa Glu Val Glu Xaa 
    130                 135                 140                 


Gln Gln Val Met Arg Asn Leu Asn Pro Pro Ser Ser Asn Trp Glu Val 
145                 150                 155                 160 


Glu Lys Leu Ser Cys Asp Leu Lys Ile His Gly Leu Glu Gln Glu Leu 
                165                 170                 175     


Glu Leu Met Arg Lys Glu Cys Ser Asp Leu Lys Ile Glu Leu Gln Lys 
            180                 185                 190         


Ala Lys Gln Xaa Asp Pro Tyr Gln Glu Asp Asn Leu Lys Ser Arg Asp 
        195                 200                 205             


Leu Gln Lys Leu Ser Ile Ser Arg Gln Ser Ile Cys Ser Xaa Ala Trp 
    210                 215                 220                 


Ser Ala Val Ala Gln Ser Trp Asp Ser Met Asn Phe Glu Asp Cys Ser 
225                 230                 235                 240 


Leu Phe Ala 
            


<210> 3786
<211> 232
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<400> 3786
Met Asp Ala Leu Val Glu Asp Asp Ile Cys Ile Leu Asn His Glu Lys 
1               5                   10                  15      


Ala His Lys Arg Asp Xaa Val Xaa Pro Val Ser Ile Tyr Ser Gly Asp 
            20                  25                  30          


Glu Ser Val Ala Ser His Phe Ala Leu Val Xaa Ala Tyr Glu Asp Ile 
        35                  40                  45              


Lys Lys Arg Leu Lys Asp Ser Glu Lys Glu Asn Ser Leu Leu Lys Lys 
    50                  55                  60                  


Arg Ile Arg Phe Leu Glu Glu Lys Leu Ile Ala Arg Phe Glu Glu Glu 
65                  70                  75                  80  


Xaa Ser Ser Val Gly Arg Glu Gln Val Asn Lys Ala Tyr His Ala Tyr 
                85                  90                  95      


Arg Glu Val Cys Ile Asp Arg Asp Asn Leu Lys Ser Lys Leu Asp Lys 
            100                 105                 110         


Met Asn Lys Asp Asn Ser Glu Ser Leu Lys Val Leu Asn Glu Gln Leu 
        115                 120                 125             


Gln Ser Lys Glu Val Glu Leu Leu Gln Leu Arg Xaa Glu Val Glu Xaa 
    130                 135                 140                 


Gln Gln Val Met Arg Asn Leu Asn Pro Pro Ser Ser Asn Trp Glu Val 
145                 150                 155                 160 


Glu Lys Leu Ser Cys Asp Leu Lys Ile His Gly Leu Glu Gln Glu Leu 
                165                 170                 175     


Glu Leu Met Arg Lys Glu Cys Ser Asp Leu Lys Ile Glu Leu Gln Lys 
            180                 185                 190         


Ala Lys Gln Xaa Asp Pro Tyr Gln Glu Asp Asn Leu Lys Ser Arg Asp 
        195                 200                 205             


Leu Gln Lys Leu Ser Ile Ser Arg Val Ser Val Ala Gln Pro Gly Val 
    210                 215                 220                 


Gln Trp Arg Asn His Gly Ile Ala 
225                 230         


<210> 3787
<211> 392
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<400> 3787
Met Asp Ala Leu Val Glu Asp Asp Ile Cys Ile Leu Asn His Glu Lys 
1               5                   10                  15      


Ala His Lys Arg Asp Xaa Val Xaa Pro Val Ser Ile Tyr Ser Gly Asp 
            20                  25                  30          


Glu Ser Val Ala Ser His Phe Ala Leu Val Xaa Ala Tyr Glu Asp Ile 
        35                  40                  45              


Lys Lys Arg Leu Lys Asp Ser Glu Lys Glu Asn Ser Leu Leu Lys Lys 
    50                  55                  60                  


Arg Ile Arg Phe Leu Glu Glu Lys Leu Ile Ala Arg Phe Glu Glu Glu 
65                  70                  75                  80  


Xaa Ser Ser Val Gly Arg Glu Gln Val Asn Lys Ala Tyr His Ala Tyr 
                85                  90                  95      


Arg Glu Val Cys Ile Asp Arg Asp Asn Leu Lys Ser Lys Leu Asp Lys 
            100                 105                 110         


Met Asn Lys Asp Asn Ser Glu Ser Leu Lys Val Leu Asn Glu Gln Leu 
        115                 120                 125             


Gln Ser Lys Glu Val Glu Leu Leu Gln Leu Arg Xaa Glu Val Glu Xaa 
    130                 135                 140                 


Gln Gln Val Met Arg Asn Leu Asn Pro Pro Ser Ser Asn Trp Glu Val 
145                 150                 155                 160 


Glu Lys Leu Ser Cys Asp Leu Lys Ile His Gly Leu Glu Gln Glu Leu 
                165                 170                 175     


Glu Leu Met Arg Lys Glu Cys Ser Asp Leu Lys Ile Glu Leu Gln Lys 
            180                 185                 190         


Ala Lys Gln Xaa Asp Pro Tyr Gln Glu Asp Asn Leu Lys Ser Arg Asp 
        195                 200                 205             


Leu Gln Lys Leu Ser Ile Ser Ser Asp Asn Met Gln His Ala Tyr Trp 
    210                 215                 220                 


Glu Leu Lys Arg Glu Met Ser Asn Leu His Leu Val Xaa Gln Val Gln 
225                 230                 235                 240 


Ala Glu Leu Leu Arg Lys Leu Lys Xaa Ser Xaa Ala Ile Lys Lys Ala 
                245                 250                 255     


Cys Ala Pro Val Gly Cys Ser Glu Asp Leu Gly Arg Asp Ser Xaa Lys 
            260                 265                 270         


Leu His Leu Met Asn Phe Xaa Ala Xaa Tyr Xaa Arg His Pro Pro Leu 
        275                 280                 285             


Leu Pro Asn Gly Lys Ala Leu Cys His Xaa Xaa Ser Ser Pro Leu Pro 
    290                 295                 300                 


Gly Asp Val Lys Val Leu Ser Glu Lys Ala Ile Leu Gln Ser Trp Xaa 
305                 310                 315                 320 


Asp Asn Glu Arg Ser Ile Pro Asn Asp Gly Xaa Cys Phe Gln Glu His 
                325                 330                 335     


Ser Ser Tyr Gly Arg Asn Ser Leu Glu Asp Asn Ser Trp Val Phe Pro 
            340                 345                 350         


Ser Pro Pro Lys Ser Ser Glu Xaa Ala Phe Gly Glu Xaa Lys Xaa Lys 
        355                 360                 365             


Xaa Leu Pro Leu Pro Asn Leu Pro Pro Leu His Tyr Leu Asp Gln His 
    370                 375                 380                 


Asn Gln Asn Cys Leu Tyr Lys Asn 
385                 390         


<210> 3788
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<400> 3788
Xaa Leu Lys Ser Arg Asp Leu Gln Lys Leu Ser Ile Ser Ser Asp Asn 
1               5                   10                  15      


Met Gln His Ala Tyr Trp Glu Leu Lys Arg Glu Met Ser Asn Leu His 
            20                  25                  30          


Leu Val Xaa Gln Val Gln Ala Glu Leu Leu Arg Lys Leu Lys Xaa Ser 
        35                  40                  45              


Xaa Ala Ile Lys Lys Ala Leu Ser Gln Asn Arg Ala Met Arg Ser Xaa 
    50                  55                  60                  


Ala Pro Val Leu Gly Xaa His Gly Val Lys Asp Lys 
65                  70                  75      


<210> 3789
<211> 150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 3789
Met Xaa Ala Ala Ser Cys Phe Gln Ser Gln Asn Pro Gly Val Ser Xaa 
1               5                   10                  15      


Val Val Leu Gly Ala Tyr Asp Leu Arg Arg Arg Glu Arg Gln Ser Arg 
            20                  25                  30          


Gln Xaa Phe Ser Ile Ser Ser Met Ser Glu Asn Gly Tyr Asp Pro Gln 
        35                  40                  45              


Gln Asn Leu Asn Asp Leu Met Leu Leu Gln Leu Asp Arg Glu Ala Asn 
    50                  55                  60                  


Leu Xaa Ser Ser Val Xaa Ile Leu Pro Leu Pro Leu Gln Asn Ala Xaa 
65                  70                  75                  80  


Val Glu Ala Gly Xaa Arg Cys Gln Val Ala Gly Trp Gly Ser Gln Arg 
                85                  90                  95      


Ser Gly Gly Arg Leu Ser Arg Phe Pro Arg Phe Val Asn Val Xaa Val 
            100                 105                 110         


Xaa Pro Glu Asp Gln Cys Arg Pro Asn Asn Val Cys Xaa Gly Val Leu 
        115                 120                 125             


Xaa Arg Arg Gly Gly Ile Cys Asn Val Ser Ala Pro Cys Gly Gly Arg 
    130                 135                 140                 


Arg Gly Pro Glu Arg Tyr 
145                 150 


<210> 3790
<211> 251
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<400> 3790
Met Xaa Arg Leu Xaa Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Gly Ser Ser Pro Leu Leu Asp Ile Val Gly Gly Arg Lys 
            20                  25                  30          


Ala Arg Pro Arg Gln Phe Pro Phe Leu Ala Ser Ile Gln Asn Gln Gly 
        35                  40                  45              


Arg His Phe Cys Gly Gly Ala Leu Ile His Ala Arg Phe Val Met Xaa 
    50                  55                  60                  


Ala Ala Ser Cys Phe Gln Ser Gln Asn Pro Gly Val Ser Xaa Val Val 
65                  70                  75                  80  


Leu Gly Ala Tyr Asp Leu Arg Arg Arg Glu Arg Gln Ser Arg Gln Xaa 
                85                  90                  95      


Phe Ser Ile Ser Ser Met Ser Glu Asn Gly Tyr Asp Pro Gln Gln Asn 
            100                 105                 110         


Leu Asn Asp Leu Met Leu Leu Gln Leu Asp Arg Glu Ala Asn Leu Xaa 
        115                 120                 125             


Ser Ser Val Xaa Ile Leu Pro Leu Pro Leu Gln Asn Ala Xaa Val Glu 
    130                 135                 140                 


Ala Gly Xaa Arg Cys Gln Val Ala Gly Trp Gly Ser Gln Arg Ser Gly 
145                 150                 155                 160 


Gly Arg Leu Ser Arg Phe Pro Arg Phe Val Asn Val Xaa Val Xaa Pro 
                165                 170                 175     


Glu Asp Gln Cys Arg Pro Asn Asn Val Cys Xaa Gly Val Leu Xaa Arg 
            180                 185                 190         


Arg Gly Gly Ile Cys Asn Gly Asp Gly Gly Xaa Pro Leu Val Cys Glu 
        195                 200                 205             


Gly Leu Ala His Gly Val Ala Ser Phe Ser Leu Gly Pro Cys Gly Arg 
    210                 215                 220                 


Gly Pro Asp Phe Phe Xaa Arg Val Ala Leu Phe Arg Asp Trp Ile Asp 
225                 230                 235                 240 


Gly Val Leu Asn Asn Pro Gly Pro Gly Pro Ala 
                245                 250     


<210> 3791
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<400> 3791
Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
1               5                   10                  15      


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
            20                  25                  30          


Ser Phe Tyr Leu Leu Tyr Tyr Xaa Glu Phe Xaa Pro Xaa Glu Lys Asp 
        35                  40                  45              


Glu Tyr Ala Cys Arg Val Asn His Val Xaa Leu Ser Gln Pro Lys Ile 
    50                  55                  60                  


Val Lys Trp Asp Arg Asp Met 
65                  70      


<210> 3792
<211> 51
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<400> 3792
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln His Ser Gly Leu Leu Xaa Ser Ser Ser Arg 
            20                  25                  30          


Glu Trp Lys Val Lys Phe Pro Glu Leu Leu Cys Val Trp Val Ser Ser 
        35                  40                  45              


Ile Arg His 
    50      


<210> 3793
<211> 101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 3793
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Xaa Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile 
        35                  40                  45              


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
    50                  55                  60                  


Tyr Leu Leu Tyr Tyr Xaa Glu Phe Xaa Pro Xaa Glu Lys Asp Glu Tyr 
65                  70                  75                  80  


Ala Cys Arg Val Asn His Val Xaa Leu Ser Gln Pro Lys Ile Val Lys 
                85                  90                  95      


Trp Asp Arg Asp Met 
            100     


<210> 3794
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<400> 3794
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Xaa Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Xaa Glu Phe Xaa Pro Xaa Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Xaa Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210> 3795
<211> 57
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(43)
<223> Selenocysteine

<400> 3795
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Arg Glu Leu Lys Lys Trp Ser Ile Gln Xaa Cys Leu Ser 
            20                  25                  30          


Ala Arg Xaa Gly Leu Ser Ile Ser Cys Xaa Xaa Leu Asn Ser Pro Pro 
        35                  40                  45              


Leu Lys Lys Met Ser Met Pro Ala Val 
    50                  55          


<210> 3796
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<400> 3796
Leu Leu Met Val Asn Gly Gln Val Glu Ser Ala Gln Phe Pro Glu Tyr 
1               5                   10                  15      


Asp Asp Leu Tyr Cys Lys Tyr Cys Phe Val Tyr Gly Gln Asp Trp Ala 
            20                  25                  30          


Pro Xaa Ala Gly Leu Glu Glu Gly Ile Ser Gln Ile Xaa Ser Lys Ser 
        35                  40                  45              


Gln Asp Val Arg Gln Ala Leu Val Trp Asn Phe Pro Ile Asp Val Xaa 
    50                  55                  60                  


Phe Lys Ser Xaa Asn Pro Tyr Gly Trp Pro Gln Ile Val Leu Ser Val 
65                  70                  75                  80  


Tyr Gly Pro Asp Val Phe Gly Asn Asp Val Val Arg Gly Tyr Gly Ala 
                85                  90                  95      


Val His Val Pro Phe Ser Pro Gly Arg His Lys Arg Xaa Ile Pro Met 
            100                 105                 110         


Phe Val Pro Glu Ser Xaa Ser Lys Leu Gln Lys Phe Xaa Arg Ser Ala 
        115                 120                 125             


Ser Cys Ser Xaa His 
    130             


<210> 3797
<211> 153
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 3797
Met Ala Xaa Ala Ser Pro Ser Val Phe Leu Leu Met Val Asn Gly Gln 
1               5                   10                  15      


Val Glu Ser Ala Gln Phe Pro Glu Tyr Asp Asp Leu Tyr Cys Lys Tyr 
            20                  25                  30          


Cys Phe Val Tyr Gly Gln Asp Trp Ala Pro Xaa Ala Gly Leu Glu Glu 
        35                  40                  45              


Gly Ile Ser Gln Ile Xaa Ser Lys Ser Gln Asp Val Arg Gln Ala Leu 
    50                  55                  60                  


Val Trp Asn Phe Pro Ile Asp Val Xaa Phe Lys Ser Xaa Asn Pro Tyr 
65                  70                  75                  80  


Gly Trp Pro Gln Ile Val Leu Ser Val Tyr Gly Pro Asp Val Phe Gly 
                85                  90                  95      


Asn Asp Val Val Arg Gly Tyr Gly Ala Val His Val Pro Phe Ser Pro 
            100                 105                 110         


Gly Arg His Lys Arg Xaa Ile Pro Met Phe Val Pro Glu Ser Xaa Ser 
        115                 120                 125             


Lys Leu Gln Lys Phe Xaa Ser Leu Cys Leu Val Ala Ser Ser Asp Leu 
    130                 135                 140                 


Gln Ala Ala Pro Pro Xaa Glu Asp Lys 
145                 150             


<210> 3798
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<400> 3798
Met Ala Xaa Ala Ser Pro Ser Val Phe Leu Leu Met Val Asn Gly Gln 
1               5                   10                  15      


Val Glu Ser Ala Gln Phe Pro Glu Tyr Asp Asp Leu Tyr Cys Lys Tyr 
            20                  25                  30          


Cys Phe Val Tyr Gly Gln Asp Trp Ala Pro Xaa Ala Gly Leu Glu Glu 
        35                  40                  45              


Gly Ile Ser Gln Ile Xaa Ser Lys Ser Gln Asp Val Arg Gln Ala Leu 
    50                  55                  60                  


Val Trp Asn Phe Pro Ile Asp Val Xaa Phe Lys Ser Xaa Asn Pro Tyr 
65                  70                  75                  80  


Gly Trp Pro Gln Ile Val Leu Ser Val Tyr Gly Pro Asp Val Phe Gly 
                85                  90                  95      


Asn Asp Val Val Arg Gly Tyr Gly Ala Val His Val Pro Phe Ser Pro 
            100                 105                 110         


Gly Arg His Lys Arg Xaa Ile Pro Met Phe Val Pro Glu Ser Xaa Ser 
        115                 120                 125             


Lys Leu Gln Lys Phe Xaa Ser Trp Phe Met Gly Arg Arg Pro Glu Tyr 
    130                 135                 140                 


Xaa Asp Pro Lys Val Val Ala Gln Gly Glu Gly Arg Glu Ala Ile Xaa 
145                 150                 155                 160 


Ala Pro Arg Lys Ala Val Phe Ser Val His Gly Leu Xaa Ser Pro Arg 
                165                 170                 175     


Ala Leu Ala Leu Val His Ile Lys Gly Xaa 
            180                 185     


<210> 3799
<211> 161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<400> 3799
Met Ala Xaa Ala Ser Pro Ser Val Phe Leu Leu Met Val Asn Gly Gln 
1               5                   10                  15      


Val Glu Ser Ala Gln Phe Pro Glu Tyr Asp Asp Leu Tyr Cys Lys Tyr 
            20                  25                  30          


Cys Phe Val Tyr Gly Gln Asp Trp Ala Pro Xaa Ala Gly Leu Glu Glu 
        35                  40                  45              


Gly Ile Ser Gln Ile Xaa Ser Lys Ser Gln Asp Val Arg Gln Ala Leu 
    50                  55                  60                  


Val Trp Asn Phe Pro Ile Asp Val Xaa Phe Lys Ser Xaa Asn Pro Tyr 
65                  70                  75                  80  


Gly Trp Pro Gln Ile Val Leu Ser Val Tyr Gly Pro Asp Val Phe Gly 
                85                  90                  95      


Asn Asp Val Val Arg Gly Tyr Gly Ala Val His Val Pro Phe Ser Pro 
            100                 105                 110         


Gly Arg His Lys Arg Xaa Ile Pro Met Phe Val Pro Glu Ser Xaa Ser 
        115                 120                 125             


Lys Leu Gln Lys Phe Xaa Ser Trp Phe Met Gly Arg Arg Pro Glu Tyr 
    130                 135                 140                 


Xaa Asp Pro Lys Val Val Ala Gln Gly Glu Gly Arg Glu Ala Gln Pro 
145                 150                 155                 160 


Gly 
    


<210> 3800
<211> 187
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 3800
Met Ala Xaa Ala Ser Pro Ser Val Phe Leu Leu Met Val Asn Gly Gln 
1               5                   10                  15      


Val Glu Ser Ala Gln Phe Pro Glu Tyr Asp Asp Leu Tyr Cys Lys Tyr 
            20                  25                  30          


Cys Phe Val Tyr Gly Gln Asp Trp Ala Pro Xaa Ala Gly Leu Glu Glu 
        35                  40                  45              


Gly Ile Ser Gln Ile Xaa Ser Lys Ser Gln Asp Val Arg Gln Ala Leu 
    50                  55                  60                  


Val Trp Asn Phe Pro Ile Asp Val Xaa Phe Lys Ser Xaa Asn Pro Tyr 
65                  70                  75                  80  


Gly Trp Pro Gln Ile Val Leu Ser Val Tyr Gly Pro Asp Val Phe Gly 
                85                  90                  95      


Asn Asp Val Val Arg Gly Tyr Gly Ala Val His Val Pro Phe Ser Pro 
            100                 105                 110         


Gly Arg His Lys Arg Xaa Ile Pro Met Phe Val Pro Glu Ser Xaa Ser 
        115                 120                 125             


Lys Leu Gln Lys Phe Xaa Ser Trp Phe Met Gly Arg Arg Pro Glu Tyr 
    130                 135                 140                 


Xaa Asp Pro Lys Val Val Ala Gln Gly Glu Gly Arg Glu Asp Glu Asn 
145                 150                 155                 160 


Ala Glu Ala Glu Ile Pro Arg Ser Xaa Trp Val Ser Leu Cys Pro Ser 
                165                 170                 175     


Pro Ala Trp Leu Met Leu Pro Phe Cys Pro Gln 
            180                 185         


<210> 3801
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<400> 3801
Met Ala Xaa Ala Ser Pro Ser Val Phe Leu Leu Met Val Asn Gly Gln 
1               5                   10                  15      


Val Glu Ser Ala Gln Phe Pro Glu Tyr Asp Asp Leu Tyr Cys Lys Tyr 
            20                  25                  30          


Cys Phe Val Tyr Gly Gln Asp Trp Ala Pro Xaa Ala Gly Leu Glu Glu 
        35                  40                  45              


Gly Ile Ser Gln Ile Xaa Ser Lys Ser Gln Asp Val Arg Gln Ala Leu 
    50                  55                  60                  


Val Trp Asn Phe Pro Ile Asp Val Xaa Phe Lys Ser Xaa Asn Pro Tyr 
65                  70                  75                  80  


Gly Trp Pro Gln Ile Val Leu Ser Val Tyr Gly Pro Asp Val Phe Gly 
                85                  90                  95      


Asn Asp Val Val Arg Gly Tyr Gly Ala Val His Val Pro Phe Ser Pro 
            100                 105                 110         


Gly Arg His Lys Arg Xaa Ile Pro Met Phe Val Pro Glu Ser Xaa Ser 
        115                 120                 125             


Lys Leu Gln Lys Phe Xaa Ser Trp Phe Met Gly Arg Arg Pro Glu Tyr 
    130                 135                 140                 


Xaa Asp Pro Lys Val Val Ala Gln Gly Glu Gly Arg Glu Val Xaa Arg 
145                 150                 155                 160 


Val Arg Ser Gln Gly Phe Val Xaa Leu Leu Phe Asn Val Val Xaa Lys 
                165                 170                 175     


Asp Met Arg Lys Leu Gly Tyr Asp Xaa Gly Pro Ser Asp Xaa Gln Gly 
            180                 185                 190         


Val Leu Gly Pro Ser Pro Pro Gln Ser Phe Pro Gln 
        195                 200                 


<210> 3802
<211> 19
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<400> 3802
Met Met Xaa Ser Xaa Ala Ser Xaa Ala Leu Cys Xaa Ala Arg Xaa Gly 
1               5                   10                  15      


Pro Pro Gln 
            


<210> 3803
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<400> 3803
Met Met Xaa Ser Xaa Ala Ser Xaa Ala Leu Cys Xaa Ala Arg Xaa Gly 
1               5                   10                  15      


Pro Pro Gln Arg Val Trp Arg Arg Gly Ser His Arg Ser His Pro Arg 
            20                  25                  30          


Ala Lys Met Cys Gly Lys His Trp Cys Gly Xaa Ser Pro Leu Met Ser 
        35                  40                  45              


Pro Leu Lys Ala Pro Xaa Pro Xaa Ala Gly His Arg Ser Cys Ser Ala 
    50                  55                  60                  


Cys Met Asp Gln Met Cys Ser Gly Xaa Met Trp Phe Glu Ala Met Gly 
65                  70                  75                  80  


Pro Cys Xaa Cys Pro Ser His Leu Ala Gly Xaa Lys Gly Pro Ser Pro 
                85                  90                  95      


Cys Leu Ser Gln Asn Leu Arg Leu Asn Cys 
            100                 105     


<210> 3804
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<400> 3804
Met Met Xaa Ser Xaa Ala Ser Xaa Ala Leu Cys Xaa Ala Arg Xaa Gly 
1               5                   10                  15      


Pro Pro Gln Arg Val Trp Arg Arg Gly Ser His Arg Ser His Pro Arg 
            20                  25                  30          


Ala Lys Met Cys Gly Lys His Trp Cys Gly Xaa Ser Pro Leu Met Ser 
        35                  40                  45              


Pro Leu Lys Ala Pro Xaa Pro Xaa Ala Gly His Arg Ser Cys Ser Ala 
    50                  55                  60                  


Cys Met Asp Gln Met Cys Ser Gly Xaa Met Trp Phe Glu Ala Met Gly 
65                  70                  75                  80  


Pro Cys Xaa Cys Pro Ser His Leu Ala Gly Xaa Lys Gly Pro Ser Pro 
                85                  90                  95      


Cys Leu Ser Gln Asn Leu Arg Leu Asn Cys Arg Ser Leu Gln Ala Gly 
            100                 105                 110         


Ser Trp Gly Gly Gly Pro Ser Xaa Gln Xaa Pro Arg Trp Trp Leu Arg 
        115                 120                 125             


Val Lys Ala Gly Lys Pro Pro Ser Gly Leu Ser Val Lys Asp Ser Ser 
    130                 135                 140                 


Val Ser Arg 
145         


<210> 3805
<211> 140
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<400> 3805
Met Met Xaa Ser Xaa Ala Ser Xaa Ala Leu Cys Xaa Ala Arg Xaa Gly 
1               5                   10                  15      


Pro Pro Gln Arg Val Trp Arg Arg Gly Ser His Arg Ser His Pro Arg 
            20                  25                  30          


Ala Lys Met Cys Gly Lys His Trp Cys Gly Xaa Ser Pro Leu Met Ser 
        35                  40                  45              


Pro Leu Lys Ala Pro Xaa Pro Xaa Ala Gly His Arg Ser Cys Ser Ala 
    50                  55                  60                  


Cys Met Asp Gln Met Cys Ser Gly Xaa Met Trp Phe Glu Ala Met Gly 
65                  70                  75                  80  


Pro Cys Xaa Cys Pro Ser His Leu Ala Gly Xaa Lys Gly Pro Ser Pro 
                85                  90                  95      


Cys Leu Ser Gln Asn Leu Arg Leu Asn Cys Arg Ser Leu Gln Ala Gly 
            100                 105                 110         


Ser Trp Gly Gly Gly Pro Ser Xaa Gln Xaa Pro Arg Trp Trp Leu Arg 
        115                 120                 125             


Val Lys Ala Gly Lys Val Lys Leu Pro Pro Leu Ser 
    130                 135                 140 


<210> 3806
<211> 213
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<400> 3806
Met Met Xaa Ser Xaa Ala Ser Xaa Ala Leu Cys Xaa Ala Arg Xaa Gly 
1               5                   10                  15      


Pro Pro Gln Arg Val Trp Arg Arg Gly Ser His Arg Ser His Pro Arg 
            20                  25                  30          


Ala Lys Met Cys Gly Lys His Trp Cys Gly Xaa Ser Pro Leu Met Ser 
        35                  40                  45              


Pro Leu Lys Ala Pro Xaa Pro Xaa Ala Gly His Arg Ser Cys Ser Ala 
    50                  55                  60                  


Cys Met Asp Gln Met Cys Ser Gly Xaa Met Trp Phe Glu Ala Met Gly 
65                  70                  75                  80  


Pro Cys Xaa Cys Pro Ser His Leu Ala Gly Xaa Lys Gly Pro Ser Pro 
                85                  90                  95      


Cys Leu Ser Gln Asn Leu Arg Leu Asn Cys Arg Ser Leu Gln Ala Gly 
            100                 105                 110         


Ser Trp Gly Gly Gly Pro Ser Xaa Gln Xaa Pro Arg Trp Trp Leu Arg 
        115                 120                 125             


Val Lys Ala Gly Lys Val Lys Leu Pro Pro Leu Ser Tyr Pro His Pro 
    130                 135                 140                 


Pro Tyr Arg Leu Gln Pro Gly Ser Gly Trp Ala Gln Gly Trp Gly Glu 
145                 150                 155                 160 


Cys Arg Gly Pro Ala Arg His Ile Gly Ala Ser Pro Gln Met Phe Pro 
                165                 170                 175     


Asp Glu Gly Leu Val Gly Ala Gln Arg Val Cys His Val Cys Leu Ser 
            180                 185                 190         


Arg Gln Pro Leu Tyr Leu Pro Val Arg Gly Leu Gly Gln Ala Leu Leu 
        195                 200                 205             


Ser Pro Phe Tyr Arg 
    210             


<210> 3807
<211> 112
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<400> 3807
Ser Asn Arg Ala Arg Pro Arg Trp Val Pro Pro Ala Pro Pro Asp Leu 
1               5                   10                  15      


Pro Trp Arg Pro Arg Val Leu Ala Ser Phe Tyr Ser Trp Ser Xaa Gly 
            20                  25                  30          


Arg Trp Arg Ala Pro Ser Phe Gln Ser Met Met Xaa Ser Xaa Ala Ser 
        35                  40                  45              


Xaa Ala Leu Cys Xaa Ala Arg Xaa Gly Pro Pro Gln Arg Val Trp Arg 
    50                  55                  60                  


Arg Gly Ser His Arg Ser His Pro Arg Ala Lys Met Cys Gly Lys His 
65                  70                  75                  80  


Trp Cys Gly Xaa Ser Pro Leu Met Ser Pro Leu Lys Ala Pro Xaa Pro 
                85                  90                  95      


Xaa Ala Ala Val Gln Leu Ala Phe Trp Lys Phe Arg Val His Gln Gly 
            100                 105                 110         


<210> 3808
<211> 25
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<400> 3808
Met Ser Leu Ser Glu Asn Ser Val Phe Ala Tyr Glu Ser Ser Val His 
1               5                   10                  15      


Ser Xaa Asn Val Leu Leu Ser Leu Asn 
            20                  25  


<210> 3809
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<400> 3809
Met Ser Leu Ser Glu Asn Ser Val Phe Ala Tyr Glu Ser Ser Val His 
1               5                   10                  15      


Ser Xaa Asn Val Leu Leu Ser Leu Asn Asp Gln Arg Lys Lys Asp Val 
            20                  25                  30          


Leu Cys Asp Val Xaa Ile Phe Val Glu Gly Gln Arg Phe Arg Ala His 
        35                  40                  45              


Arg Ser Val Leu Ala Ala Cys Ser Ser Tyr Phe His Ser Arg Ile Val 
    50                  55                  60                  


Gly Gln Ala Asp Gly Glu Leu Asn Ile Xaa Leu Pro Glu Glu Val Xaa 
65                  70                  75                  80  


Val Lys Gly Phe Glu Pro Leu Ile Gln Phe Ala Tyr Xaa Ala Lys Leu 
                85                  90                  95      


Ile Leu Ser Lys Glu Asn Val Asp Glu Val Cys Lys Cys Val Glu Phe 
            100                 105                 110         


Leu Ser Val His Asn Ile Glu Glu Ser Cys Phe Gln Phe Leu Lys Phe 
        115                 120                 125             


Lys Phe Leu Asp Ser Xaa Ala Asp Gln Gln Glu Cys Pro Arg Lys Lys 
    130                 135                 140                 


Cys Phe Ser Ser His Cys Gln Lys Xaa Asp Leu Lys Leu Ser Leu Leu 
145                 150                 155                 160 


Asp Gln Arg Asp Leu Glu Xaa Asp Glu Val 
                165                 170 


<210> 3810
<211> 220
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<400> 3810
Met Ser Leu Ser Glu Asn Ser Val Phe Ala Tyr Glu Ser Ser Val His 
1               5                   10                  15      


Ser Xaa Asn Val Leu Leu Ser Leu Asn Asp Gln Arg Lys Lys Asp Val 
            20                  25                  30          


Leu Cys Asp Val Xaa Ile Phe Val Glu Gly Gln Arg Phe Arg Ala His 
        35                  40                  45              


Arg Ser Val Leu Ala Ala Cys Ser Ser Tyr Phe His Ser Arg Ile Val 
    50                  55                  60                  


Gly Gln Ala Asp Gly Glu Leu Asn Ile Xaa Leu Pro Glu Glu Val Xaa 
65                  70                  75                  80  


Val Lys Gly Phe Glu Pro Leu Ile Gln Phe Ala Tyr Xaa Ala Lys Leu 
                85                  90                  95      


Ile Leu Ser Lys Glu Asn Val Asp Glu Val Cys Lys Cys Val Glu Phe 
            100                 105                 110         


Leu Ser Val His Asn Ile Glu Glu Ser Cys Phe Gln Phe Leu Lys Phe 
        115                 120                 125             


Lys Phe Leu Asp Ser Xaa Ala Asp Gln Gln Glu Cys Pro Arg Lys Lys 
    130                 135                 140                 


Cys Phe Ser Ser His Cys Gln Lys Xaa Asp Leu Lys Leu Ser Leu Leu 
145                 150                 155                 160 


Asp Gln Arg Asp Leu Glu Xaa Asp Glu Val Glu Glu Phe Leu Glu Asn 
                165                 170                 175     


Lys Asn Val Gln Xaa Pro Gln Cys Lys Leu Arg Arg Tyr Gln Gly Asn 
            180                 185                 190         


Ala Lys Ala Ser Pro Pro Leu Gln Asp Ser Ala Ser Gln Xaa Tyr Glu 
        195                 200                 205             


Ser Met Cys Leu Glu Lys Asp Ala Ala Leu Ala Leu 
    210                 215                 220 


<210> 3811
<211> 225
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<400> 3811
Met Ser Leu Ser Glu Asn Ser Val Phe Ala Tyr Glu Ser Ser Val His 
1               5                   10                  15      


Ser Xaa Asn Val Leu Leu Ser Leu Asn Asp Gln Arg Lys Lys Asp Val 
            20                  25                  30          


Leu Cys Asp Val Xaa Ile Phe Val Glu Gly Gln Arg Phe Arg Ala His 
        35                  40                  45              


Arg Ser Val Leu Ala Ala Cys Ser Ser Tyr Phe His Ser Arg Ile Val 
    50                  55                  60                  


Gly Gln Ala Asp Gly Glu Leu Asn Ile Xaa Leu Pro Glu Glu Val Xaa 
65                  70                  75                  80  


Val Lys Gly Phe Glu Pro Leu Ile Gln Phe Ala Tyr Xaa Ala Lys Leu 
                85                  90                  95      


Ile Leu Ser Lys Glu Asn Val Asp Glu Val Cys Lys Cys Val Glu Phe 
            100                 105                 110         


Leu Ser Val His Asn Ile Glu Glu Ser Cys Phe Gln Phe Leu Lys Phe 
        115                 120                 125             


Lys Phe Leu Asp Ser Xaa Ala Asp Gln Gln Glu Cys Pro Arg Lys Lys 
    130                 135                 140                 


Cys Phe Ser Ser His Cys Gln Lys Xaa Asp Leu Lys Leu Ser Leu Leu 
145                 150                 155                 160 


Asp Gln Arg Asp Leu Glu Xaa Asp Glu Val Glu Glu Phe Leu Glu Asn 
                165                 170                 175     


Lys Asn Val Gln Xaa Pro Gln Cys Lys Leu Arg Arg Tyr Gln Gly Asn 
            180                 185                 190         


Ala Lys Ala Ser Pro Pro Leu Gln Asp Ser Ala Ser Gln Xaa Tyr Glu 
        195                 200                 205             


Ser Met Cys Leu Glu Lys Asp Ala Ala Leu Ala Leu Pro Ser Leu Cys 
    210                 215                 220                 


Pro 
225 


<210> 3812
<211> 736
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(734)
<223> Selenocysteine

<400> 3812
Met Ser Leu Ser Glu Asn Ser Val Phe Ala Tyr Glu Ser Ser Val His 
1               5                   10                  15      


Ser Xaa Asn Val Leu Leu Ser Leu Asn Asp Gln Arg Lys Lys Asp Val 
            20                  25                  30          


Leu Cys Asp Val Xaa Ile Phe Val Glu Gly Gln Arg Phe Arg Ala His 
        35                  40                  45              


Arg Ser Val Leu Ala Ala Cys Ser Ser Tyr Phe His Ser Arg Ile Val 
    50                  55                  60                  


Gly Gln Ala Asp Gly Glu Leu Asn Ile Xaa Leu Pro Glu Glu Val Xaa 
65                  70                  75                  80  


Val Lys Gly Phe Glu Pro Leu Ile Gln Phe Ala Tyr Xaa Ala Lys Leu 
                85                  90                  95      


Ile Leu Ser Lys Glu Asn Val Asp Glu Val Cys Lys Cys Val Glu Phe 
            100                 105                 110         


Leu Ser Val His Asn Ile Glu Glu Ser Cys Phe Gln Phe Leu Lys Phe 
        115                 120                 125             


Lys Phe Leu Asp Ser Xaa Ala Asp Gln Gln Glu Cys Pro Arg Lys Lys 
    130                 135                 140                 


Cys Phe Ser Ser His Cys Gln Lys Xaa Asp Leu Lys Leu Ser Leu Leu 
145                 150                 155                 160 


Asp Gln Arg Asp Leu Glu Xaa Asp Glu Val Glu Glu Phe Leu Glu Asn 
                165                 170                 175     


Lys Asn Val Gln Xaa Pro Gln Cys Lys Leu Arg Arg Tyr Gln Gly Asn 
            180                 185                 190         


Ala Lys Ala Ser Pro Pro Leu Gln Asp Ser Ala Ser Gln Xaa Tyr Glu 
        195                 200                 205             


Ser Met Cys Leu Glu Lys Asp Ala Ala Leu Ala Leu Pro Ser Leu Cys 
    210                 215                 220                 


Pro Lys Tyr Arg Lys Phe Gln Lys Ala Phe Gly Xaa Asp Arg Val Arg 
225                 230                 235                 240 


Xaa Gly Glu Ser Ser Val Lys Asp Ile His Ala Ser Val Gln Pro Asn 
                245                 250                 255     


Glu Arg Ser Glu Asn Glu Cys Leu Gly Gly Val Pro Glu Cys Arg Asp 
            260                 265                 270         


Leu Gln Val Met Leu Lys Cys Asp Glu Ser Lys Leu Ala Met Glu Pro 
        275                 280                 285             


Glu Glu Xaa Lys Lys Asp Pro Ala Ser Gln Cys Pro Xaa Glu Lys Ser 
    290                 295                 300                 


Glu Val Xaa Pro Phe Pro His Asn Ser Ser Ile Asp Pro His Gly Leu 
305                 310                 315                 320 


Tyr Ser Leu Ser Leu Leu His Xaa Tyr Asp Gln Tyr Gly Asp Leu Asn 
                325                 330                 335     


Phe Ala Gly Met Gln Asn Xaa Xaa Val Leu Xaa Glu Lys Pro Leu Ser 
            340                 345                 350         


Gly Xaa Asp Val Gln Glu Lys Xaa Phe Gly Glu Ser Gln Asp Leu Pro 
        355                 360                 365             


Leu Lys Ser Asp Leu Gly Xaa Arg Glu Asp Ser Ser Val Ala Ser Ser 
    370                 375                 380                 


Asp Arg Ser Ser Val Glu Arg Glu Val Ala Glu His Leu Ala Lys Gly 
385                 390                 395                 400 


Phe Trp Ser Asp Ile Cys Ser Xaa Asp Xaa Pro Cys Gln Met Gln Leu 
                405                 410                 415     


Ser Pro Ala Val Ala Lys Asp Gly Ser Glu Gln Ile Ser Gln Lys Arg 
            420                 425                 430         


Ser Glu Cys Pro Trp Leu Gly Ile Arg Ile Ser Glu Ser Pro Glu Pro 
        435                 440                 445             


Gly Gln Arg Xaa Phe Xaa Xaa Leu Ser Ser Val Asn Cys Pro Phe Ile 
    450                 455                 460                 


Ser Xaa Leu Ser Xaa Glu Gly Cys Ser Ser Asn Leu Glu Ile Gly Asn 
465                 470                 475                 480 


Asp Asp Tyr Val Ser Glu Pro Gln Gln Glu Pro Cys Pro Tyr Ala Cys 
                485                 490                 495     


Val Ile Ser Leu Gly Asp Asp Ser Glu Xaa Asp Xaa Glu Gly Asp Ser 
            500                 505                 510         


Glu Ser Cys Ser Ala Arg Glu Gln Glu Cys Glu Val Lys Leu Pro Phe 
        515                 520                 525             


Asn Ala Gln Arg Ile Ile Ser Leu Ser Arg Asn Asp Phe Gln Ser Leu 
    530                 535                 540                 


Leu Lys Met His Lys Leu Xaa Pro Glu Gln Leu Asp Cys Ile His Asp 
545                 550                 555                 560 


Ile Arg Arg Arg Ser Lys Asn Arg Ile Ala Ala Gln Arg Cys Arg Lys 
                565                 570                 575     


Arg Lys Leu Asp Cys Ile Gln Asn Leu Glu Ser Glu Ile Glu Lys Leu 
            580                 585                 590         


Gln Ser Glu Lys Glu Ser Leu Leu Lys Glu Arg Asp His Ile Leu Ser 
        595                 600                 605             


Xaa Leu Gly Glu Xaa Lys Gln Asn Leu Xaa Gly Leu Cys Gln Lys Val 
    610                 615                 620                 


Cys Lys Glu Ala Ala Leu Ser Gln Glu Gln Ile Gln Ile Leu Ala Lys 
625                 630                 635                 640 


Tyr Ser Ala Ala Asp Cys Pro Leu Ser Phe Leu Ile Ser Glu Lys Asp 
                645                 650                 655     


Lys Ser Xaa Pro Asp Gly Glu Leu Ala Leu Pro Ser Ile Phe Ser Leu 
            660                 665                 670         


Ser Asp Arg Pro Pro Ala Val Leu Pro Pro Cys Ala Arg Gly Asn Ser 
        675                 680                 685             


Glu Pro Gly Tyr Ala Arg Gly Gln Glu Ser Gln Gln Met Ser Xaa Ala 
    690                 695                 700                 


Xaa Ser Glu Gln Ala Gly Pro Ala Glu Gln Cys Arg Gln Ser Gly Gly 
705                 710                 715                 720 


Ile Ser Asp Phe Cys Gln Gln Met Xaa Asp Lys Cys Xaa Xaa Asp Glu 
                725                 730                 735     


<210> 3813
<211> 218
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<400> 3813
Xaa Pro Trp Leu Gly Ile Arg Ile Ser Glu Ser Pro Glu Pro Gly Gln 
1               5                   10                  15      


Arg Xaa Phe Xaa Xaa Leu Ser Ser Val Asn Cys Pro Phe Ile Ser Xaa 
            20                  25                  30          


Leu Ser Xaa Glu Gly Cys Ser Ser Asn Leu Glu Ile Gly Asn Asp Asp 
        35                  40                  45              


Tyr Val Ser Glu Pro Gln Gln Glu Pro Cys Pro Tyr Ala Cys Val Ile 
    50                  55                  60                  


Ser Leu Gly Asp Asp Ser Glu Xaa Asp Xaa Glu Gly Asp Ser Glu Ser 
65                  70                  75                  80  


Cys Ser Ala Arg Glu Gln Glu Cys Glu Val Lys Leu Pro Phe Asn Ala 
                85                  90                  95      


Gln Arg Ile Ile Ser Leu Ser Arg Asn Asp Phe Gln Ser Leu Leu Lys 
            100                 105                 110         


Met His Lys Leu Xaa Pro Glu Gln Leu Asp Cys Ile His Asp Ile Arg 
        115                 120                 125             


Arg Arg Ser Lys Asn Arg Ile Ala Ala Gln Arg Cys Arg Lys Arg Lys 
    130                 135                 140                 


Leu Asp Cys Ile Gln Asn Leu Glu Ser Glu Ile Glu Lys Leu Asn His 
145                 150                 155                 160 


Gly Leu Trp Ser Leu Asn Gln Gln Pro Trp Phe Ala Asn Ile Pro Cys 
                165                 170                 175     


Xaa Ile Val Glu Xaa Gly Trp Met Pro Cys Ala Leu Ser Gly His Val 
            180                 185                 190         


Arg Pro Xaa Glu Gly Gln Ile Arg Val Lys Arg Lys Pro Glu Asp Gly 
        195                 200                 205             


Arg Asp Ile Phe Glu Gly Xaa Ser Cys Gln 
    210                 215             


<210> 3814
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 3814
Xaa Ser Glu Pro Gln Gln Glu Pro Cys Pro Tyr Ala Cys Val Ile Ser 
1               5                   10                  15      


Leu Gly Asp Asp Ser Glu Xaa Asp Xaa Glu Gly Asp Ser Glu Ser Cys 
            20                  25                  30          


Ser Ala Arg Glu Gln Glu Cys Glu Val Lys Leu Pro Phe Asn Ala Gln 
        35                  40                  45              


Arg Ile Ile Ser Leu Ser Arg Asn Asp Phe Gln Ser Leu Leu Lys Met 
    50                  55                  60                  


His Lys Leu Xaa Pro Glu Gln Leu Asp Cys Ile His Asp Ile Arg Arg 
65                  70                  75                  80  


Arg Ser Lys Asn Arg Ile Ala Ala Gln Arg Cys Arg Lys Arg Lys Leu 
                85                  90                  95      


Asp Cys Ile Gln Asn Leu Glu Ser Glu Ile Glu Lys Leu Pro Xaa Ser 
            100                 105                 110         


His Ala Pro Ser Trp Arg Leu Ala Gly Cys Pro Val Leu Tyr Gln Gly 
        115                 120                 125             


Met Ser Asp Gln Gln Arg Gly Lys Ser Glu 
    130                 135             


<210> 3815
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<400> 3815
Met Ser Val Asp Glu Lys Pro Asp Ser Pro Met Tyr Val Tyr Glu Ser 
1               5                   10                  15      


Xaa Val His Cys Xaa Asn Ile Leu Leu Gly Leu Asn Asp Gln Arg Lys 
            20                  25                  30          


Lys Asp Ile Leu Cys Asp Val Xaa Leu Ile Val Glu Arg Lys Glu Phe 
        35                  40                  45              


Arg Ala His Arg Ala Val Leu Ala Ala Cys Ser Glu Tyr Phe Trp Gln 
    50                  55                  60                  


Ala Leu Val Gly Gln Xaa Lys Asn Asp Leu Val Val Ser Leu Pro Glu 
65                  70                  75                  80  


Glu 
    


<210> 3816
<211> 841
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<400> 3816
Met Ser Val Asp Glu Lys Pro Asp Ser Pro Met Tyr Val Tyr Glu Ser 
1               5                   10                  15      


Xaa Val His Cys Xaa Asn Ile Leu Leu Gly Leu Asn Asp Gln Arg Lys 
            20                  25                  30          


Lys Asp Ile Leu Cys Asp Val Xaa Leu Ile Val Glu Arg Lys Glu Phe 
        35                  40                  45              


Arg Ala His Arg Ala Val Leu Ala Ala Cys Ser Glu Tyr Phe Trp Gln 
    50                  55                  60                  


Ala Leu Val Gly Gln Xaa Lys Asn Asp Leu Val Val Ser Leu Pro Glu 
65                  70                  75                  80  


Glu Val Xaa Ala Arg Gly Phe Gly Pro Leu Leu Gln Phe Ala Tyr Xaa 
                85                  90                  95      


Ala Lys Leu Leu Leu Ser Arg Glu Asn Ile Arg Glu Val Ile Arg Cys 
            100                 105                 110         


Ala Glu Phe Leu Arg Met His Asn Leu Glu Asp Ser Cys Phe Ser Phe 
        115                 120                 125             


Leu Gln Xaa Gln Leu Leu Asn Ser Glu Asp Gly Leu Phe Val Cys Arg 
    130                 135                 140                 


Lys Asp Ala Ala Cys Gln Arg Pro His Glu Asp Cys Glu Asn Ser Ala 
145                 150                 155                 160 


Gly Glu Glu Glu Asp Glu Glu Glu Glu Xaa Met Asp Ser Glu Xaa Ala 
                165                 170                 175     


Lys Met Ala Cys Pro Arg Asp Gln Met Leu Pro Glu Pro Ile Ser Phe 
            180                 185                 190         


Glu Ala Ala Ala Ile Pro Val Ala Glu Lys Glu Glu Ala Leu Leu Pro 
        195                 200                 205             


Glu Pro Asp Val Pro Xaa Asp Xaa Lys Glu Ser Ser Glu Lys Asp Ala 
    210                 215                 220                 


Leu Xaa Gln Tyr Pro Arg Tyr Lys Lys Tyr Gln Leu Ala Cys Xaa Lys 
225                 230                 235                 240 


Asn Val Tyr Asn Ala Ser Ser His Ser Xaa Ser Gly Phe Ala Ser Xaa 
                245                 250                 255     


Phe Arg Glu Asp Asn Ser Ser Asn Ser Leu Lys Pro Gly Leu Ala Arg 
            260                 265                 270         


Gly Gln Ile Lys Ser Glu Pro Pro Ser Glu Glu Asn Glu Glu Glu Ser 
        275                 280                 285             


Ile Xaa Leu Cys Leu Ser Gly Asp Glu Pro Asp Ala Lys Asp Arg Ala 
    290                 295                 300                 


Gly Asp Val Glu Met Asp Arg Lys Gln Pro Ser Pro Ala Pro Xaa Pro 
305                 310                 315                 320 


Xaa Ala Pro Ala Gly Ala Ala Cys Leu Glu Arg Ser Arg Ser Val Ala 
                325                 330                 335     


Ser Pro Ser Cys Leu Arg Ser Leu Phe Ser Ile Xaa Lys Ser Val Glu 
            340                 345                 350         


Leu Ser Gly Leu Pro Ser Xaa Ser Gln Gln His Phe Ala Arg Ser Pro 
        355                 360                 365             


Ala Cys Pro Phe Asp Lys Gly Ile Xaa Gln Gly Asp Leu Lys Xaa Asp 
    370                 375                 380                 


Tyr Xaa Pro Phe Xaa Gly Asn Tyr Gly Gln Pro His Val Gly Gln Lys 
385                 390                 395                 400 


Glu Val Ser Asn Phe Xaa Met Gly Ser Pro Leu Arg Gly Pro Gly Leu 
                405                 410                 415     


Glu Ala Leu Cys Lys Gln Glu Gly Glu Leu Asp Arg Arg Ser Val Ile 
            420                 425                 430         


Phe Ser Ser Ser Ala Cys Asp Gln Val Ser Xaa Ser Val His Ser Tyr 
        435                 440                 445             


Ser Gly Val Ser Ser Leu Asp Lys Asp Leu Ser Glu Pro Val Pro Lys 
    450                 455                 460                 


Gly Leu Trp Val Gly Ala Gly Gln Ser Leu Pro Ser Ser Gln Ala Tyr 
465                 470                 475                 480 


Ser His Gly Gly Leu Met Ala Asp His Leu Pro Gly Arg Met Arg Pro 
                485                 490                 495     


Asn Xaa Ser Cys Pro Val Pro Ile Lys Val Cys Pro Arg Ser Pro Pro 
            500                 505                 510         


Leu Glu Xaa Arg Xaa Arg Xaa Ser Ser Ser Cys Ser Ser Tyr Ser Tyr 
        515                 520                 525             


Ala Glu Asp Gly Ser Gly Gly Ser Pro Cys Ser Leu Pro Leu Cys Glu 
    530                 535                 540                 


Phe Ser Ser Ser Pro Cys Ser Gln Gly Ala Arg Phe Leu Ala Xaa Glu 
545                 550                 555                 560 


His Gln Glu Pro Gly Leu Met Gly Asp Gly Met Tyr Asn Gln Val Arg 
                565                 570                 575     


Pro Gln Ile Lys Cys Glu Gln Ser Tyr Gly Xaa Asn Ser Ser Asp Glu 
            580                 585                 590         


Ser Gly Ser Phe Ser Glu Ala Asp Ser Glu Ser Cys Pro Val Gln Asp 
        595                 600                 605             


Arg Gly Gln Glu Val Lys Leu Pro Phe Pro Val Asp Gln Ile Xaa Asp 
    610                 615                 620                 


Leu Pro Arg Asn Asp Phe Gln Met Met Ile Lys Met His Lys Leu Xaa 
625                 630                 635                 640 


Ser Glu Gln Leu Glu Phe Ile His Asp Val Arg Arg Arg Ser Lys Asn 
                645                 650                 655     


Arg Ile Ala Ala Gln Arg Cys Arg Lys Arg Lys Leu Asp Cys Ile Gln 
            660                 665                 670         


Asn Leu Glu Cys Glu Ile Arg Lys Leu Val Cys Glu Lys Glu Lys Leu 
        675                 680                 685             


Leu Ser Glu Arg Asn Gln Leu Lys Ala Cys Met Gly Glu Leu Leu Asp 
    690                 695                 700                 


Asn Phe Ser Cys Leu Ser Gln Glu Val Cys Arg Asp Ile Gln Ser Pro 
705                 710                 715                 720 


Glu Gln Ile Gln Ala Leu His Arg Tyr Cys Pro Val Leu Arg Pro Met 
                725                 730                 735     


Asp Leu Pro Xaa Ala Ser Ser Ile Asn Pro Ala Pro Leu Gly Ala Glu 
            740                 745                 750         


Gln Asn Ile Ala Ala Ser Gln Cys Ala Val Gly Glu Asn Val Pro Cys 
        755                 760                 765             


Cys Leu Glu Pro Gly Ala Ala Pro Pro Gly Pro Pro Trp Ala Pro Ser 
    770                 775                 780                 


Asn Xaa Ser Glu Asn Cys Xaa Ser Gly Arg Arg Leu Glu Gly Xaa Asp 
785                 790                 795                 800 


Pro Gly Xaa Phe Ser Glu Arg Gly Pro Pro Leu Glu Pro Arg Ser Gln 
                805                 810                 815     


Xaa Val Xaa Val Asp Phe Cys Gln Glu Met Xaa Asp Lys Cys Xaa Xaa 
            820                 825                 830         


Asp Glu Gln Pro Arg Lys Asp Tyr Xaa 
        835                 840     


<210> 3817
<211> 157
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 3817
Met Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu Asp Ser Ser 
1               5                   10                  15      


Ser Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro Ser 
            20                  25                  30          


Gly Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu Trp Asp Ala 
        35                  40                  45              


Ser His Gln Gln Glu Gln Pro Xaa Ser Ser Ser His His Gly Glu Gly 
    50                  55                  60                  


Xaa Ser Ser Pro Glu Glu Arg Gly His Ser Asn Ala Asp Ala Ala Lys 
65                  70                  75                  80  


Leu Gln Leu Asp Ala Ser Leu Pro Val Leu Val Gly Ser Glu Leu Gly 
                85                  90                  95      


Gln Gly Lys Leu Arg Pro Leu Pro Val Xaa Phe Ala Pro His Pro Glu 
            100                 105                 110         


Xaa Pro Pro Val Pro Xaa Ala Leu Gly Ser His Leu Glu Tyr Gly Arg 
        115                 120                 125             


Lys Tyr Phe Pro Gln Ala Tyr Ala Lys Arg Gly Ser Val Leu Ser Pro 
    130                 135                 140                 


Leu Glu Gly Gly Leu Xaa Gln Ile Pro Phe Arg Cys Val 
145                 150                 155         


<210> 3818
<211> 168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 3818
Met Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu Asp Ser Ser 
1               5                   10                  15      


Ser Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro Ser 
            20                  25                  30          


Gly Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu Trp Asp Ala 
        35                  40                  45              


Ser His Gln Gln Glu Gln Pro Xaa Ser Ser Ser His His Gly Gly Ala 
    50                  55                  60                  


Gly Ala Val Glu Ile Arg Ser Arg His Ser Ser Tyr Pro Ala Gly Xaa 
65                  70                  75                  80  


Glu Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe Arg Gly Arg 
                85                  90                  95      


Ser Arg Ser Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg Tyr Gly Arg 
            100                 105                 110         


Glu Leu Arg Arg Met Ser Asp Glu Phe Val Asp Ser Phe Lys Lys Gly 
        115                 120                 125             


Leu Pro Arg Pro Lys Ser Ala Gly Xaa Ala Xaa Gln Met Arg Gln Ser 
    130                 135                 140                 


Ser Ser Trp Xaa Arg Val Phe Gln Ser Trp Trp Asp Arg Asn Leu Gly 
145                 150                 155                 160 


Arg Gly Ser Ser Ala Pro Ser Gln 
                165             


<210> 3819
<211> 163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 3819
Met Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu Asp Ser Ser 
1               5                   10                  15      


Ser Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro Ser 
            20                  25                  30          


Gly Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu Trp Asp Ala 
        35                  40                  45              


Ser His Gln Gln Glu Gln Pro Xaa Ser Ser Ser His His Gly Gly Arg 
    50                  55                  60                  


Xaa Ser Tyr Ser Pro Ser Trp Glu Ser Glu Asp Ser Glu Asn Pro Ser 
65                  70                  75                  80  


Ala Gly Met Leu Ala Glu Ala Ser Ala Gly Met Ser Ala Pro Ala Ala 
                85                  90                  95      


Asp Ser Glu Ala Gln His Ala Glu Asn Val Lys Leu Glu Ala Leu Gly 
            100                 105                 110         


Leu Trp Arg Ser Gly Val Ala Xaa Ala Pro Xaa Pro Arg Gly Arg Arg 
        115                 120                 125             


Xaa Xaa Lys Gly Trp Gly Arg Ser Pro Ala Pro Phe Gly Ala Ala Arg 
    130                 135                 140                 


Ala Arg Arg Pro Pro Xaa Ser Gly Gln His Ser Ala Met Ala Ala Ser 
145                 150                 155                 160 


Ser Gly Gly 
            


<210> 3820
<211> 51
<212> PRT
<213> Homo sapiens

<400> 3820
Met Gly Glu Glu Pro Ser Pro Phe Arg Gly Arg Ser Arg Ser Ala Pro 
1               5                   10                  15      


Pro Asn Leu Trp Ala Ala Gln Arg Tyr Gly Arg Glu Leu Arg Arg Met 
            20                  25                  30          


Ser Asp Glu Phe Val Asp Ser Phe Lys Lys Gly Leu Pro Arg Pro Lys 
        35                  40                  45              


Ser Ala Gly 
    50      


<210> 3821
<211> 64
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<400> 3821
Met Gly Glu Glu Pro Ser Pro Phe Arg Gly Arg Ser Arg Ser Ala Pro 
1               5                   10                  15      


Pro Asn Leu Trp Ala Ala Gln Arg Tyr Gly Arg Glu Leu Arg Arg Met 
            20                  25                  30          


Ser Asp Glu Phe Val Asp Ser Phe Lys Lys Gly Leu Pro Arg Pro Lys 
        35                  40                  45              


Ser Ala Gly Xaa Ala Xaa Gln Met Arg Gln Ser Ser Ser Trp Xaa Arg 
    50                  55                  60                  


<210> 3822
<211> 63
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<400> 3822
Asp Gly Cys Arg Val Met Leu Ile Gly Lys Lys Asn Ser Pro Gln Glu 
1               5                   10                  15      


Glu Val Glu Leu Lys Lys Leu Lys His Leu Glu Lys Ser Val Glu Lys 
            20                  25                  30          


Ile Ala Asp Gln Leu Glu Glu Leu Asn Lys Glu Leu Xaa Gly Ile Gln 
        35                  40                  45              


Gln Arg Trp Gly Phe Xaa Met Leu Ala Arg Leu Val Ser Asn Ser 
    50                  55                  60              


<210> 3823
<211> 345
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<400> 3823
Leu Ala Gln Arg Gly Gly Ala Arg Arg Pro Arg Gly Asp Arg Glu Arg 
1               5                   10                  15      


Leu Gly Ser Arg Leu Arg Ala Leu Arg Pro Gly Arg Glu Pro Arg Gln 
            20                  25                  30          


Ser Glu Pro Pro Ala Gln Arg Gly Pro Pro Pro Ser Gly Arg Pro Pro 
        35                  40                  45              


Ala Arg Ser Xaa Ala Ser Gly His Asp Arg Pro Xaa Arg Gly Ala Ala 
    50                  55                  60                  


Ala Gly Ala Arg Arg Pro Arg Met Lys Lys Lys Xaa Arg Arg Arg Ser 
65                  70                  75                  80  


Xaa Arg Ser Glu Glu Leu Xaa Arg Ser Glu Glu Leu Xaa Leu Ser Glu 
                85                  90                  95      


Glu Ala Xaa Trp Ser Glu Glu Ala Xaa Gln Ser Glu Glu Ala Xaa Gln 
            100                 105                 110         


Gly Glu Glu Met Asn Arg Ser Gln Glu Val Xaa Arg Asp Glu Glu Ser 
        115                 120                 125             


Xaa Arg Ser Glu Glu Val Xaa Arg Glu Glu Met Ala Ala Ala Gly Leu 
    130                 135                 140                 


Xaa Val Xaa Val Xaa His Ser Asn Glu Lys His Asp Leu His Val Xaa 
145                 150                 155                 160 


Ser Gln Gln Gly Ser Ser Glu Pro Val Val Gln Asp Leu Ala Gln Val 
                165                 170                 175     


Val Glu Glu Val Ile Gly Val Pro Gln Ser Phe Gln Lys Leu Ile Phe 
            180                 185                 190         


Lys Gly Lys Ser Leu Lys Glu Met Glu Xaa Pro Leu Ser Ala Leu Gly 
        195                 200                 205             


Ile Gln Asp Gly Cys Arg Val Met Leu Ile Gly Lys Lys Asn Ser Pro 
    210                 215                 220                 


Gln Glu Glu Val Glu Leu Lys Lys Leu Lys His Leu Glu Lys Ser Val 
225                 230                 235                 240 


Glu Lys Ile Ala Asp Gln Leu Glu Glu Leu Asn Lys Glu Leu Xaa Gly 
                245                 250                 255     


Ile Gln Gln Gly Phe Leu Pro Lys Asp Leu Gln Ala Glu Ala Leu Cys 
            260                 265                 270         


Lys Leu Asp Arg Arg Val Lys Ala Xaa Ile Glu Gln Phe Met Lys Ile 
        275                 280                 285             


Leu Glu Glu Ile Asp Xaa Leu Ile Leu Pro Glu Asn Phe Lys Asp Ser 
    290                 295                 300                 


Arg Leu Lys Arg Lys Gly Leu Val Lys Lys Val Gln Ala Phe Leu Ala 
305                 310                 315                 320 


Glu Cys Asp Xaa Val Glu Gln Asn Ile Cys Gln Glu Xaa Glu Arg Leu 
                325                 330                 335     


Gln Ser Xaa Asn Phe Ala Leu Ala Glu 
            340                 345 


<210> 3824
<211> 48
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<400> 3824
Met Asn Arg Ser Gln Glu Val Xaa Arg Asp Glu Glu Ser Xaa Arg Ser 
1               5                   10                  15      


Glu Glu Ala Met Arg Ser Xaa Xaa Phe Met Leu Pro Pro Ser Arg Ala 
            20                  25                  30          


Ala Val Asn Gln Leu Ser Lys Xaa Trp Pro Arg Leu Leu Lys Arg Ser 
        35                  40                  45              


<210> 3825
<211> 150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<400> 3825
Met Asn Arg Ser Gln Glu Val Xaa Arg Asp Glu Glu Ser Xaa Arg Ser 
1               5                   10                  15      


Glu Glu Val Xaa Arg Glu Glu Met Ala Ala Ala Gly Leu Xaa Val Xaa 
            20                  25                  30          


Val Xaa His Ser Glu Cys Arg Ala Pro Gly Asn Glu Lys His Asp Leu 
        35                  40                  45              


His Val Xaa Ser Gln Gln Gly Ser Ser Glu Pro Val Val Gln Asp Leu 
    50                  55                  60                  


Ala Gln Val Val Glu Glu Val Ile Gly Val Pro Gln Ser Phe Gln Lys 
65                  70                  75                  80  


Leu Ile Phe Lys Gly Lys Ser Leu Lys Glu Met Glu Xaa Pro Leu Ser 
                85                  90                  95      


Ala Leu Gly Ile Gln Asp Gly Cys Arg Val Met Leu Ile Gly Lys Lys 
            100                 105                 110         


Asn Ser Pro Gln Glu Glu Val Glu Leu Lys Lys Leu Lys His Leu Glu 
        115                 120                 125             


Lys Ser Val Glu Lys Ile Ala Asp Gln Leu Glu Glu Leu Asn Lys Glu 
    130                 135                 140                 


Leu Xaa Gly Ile Gln Gln 
145                 150 


<210> 3826
<211> 94
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<400> 3826
Met Asn Arg Ser Gln Glu Val Xaa Arg Asp Glu Glu Ser Xaa Arg Ser 
1               5                   10                  15      


Glu Glu Val Xaa Arg Glu Glu Met Ala Ala Ala Gly Leu Xaa Val Xaa 
            20                  25                  30          


Val Xaa His Ser Glu Cys Arg Ala Pro Gly Asn Glu Lys His Asp Leu 
        35                  40                  45              


His Val Xaa Ser Gln Gln Gly Ser Ser Glu Pro Val Val Gln Asp Leu 
    50                  55                  60                  


Ala Gln Val Val Glu Glu Val Ile Gly Val Pro Gln Ser Phe Gln Lys 
65                  70                  75                  80  


Leu Ile Phe Lys Val Leu Gln Gln Ile Phe Ile Glu Asp Leu 
                85                  90                  


<210> 3827
<211> 230
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<400> 3827
Met Asn Arg Ser Gln Glu Val Xaa Arg Asp Glu Glu Ser Xaa Arg Ser 
1               5                   10                  15      


Glu Glu Val Xaa Arg Glu Glu Met Ala Ala Ala Gly Leu Xaa Val Xaa 
            20                  25                  30          


Val Xaa His Ser Asn Glu Lys His Asp Leu His Val Xaa Ser Gln Gln 
        35                  40                  45              


Gly Ser Ser Glu Pro Val Val Gln Asp Leu Ala Gln Val Val Glu Glu 
    50                  55                  60                  


Val Ile Gly Val Pro Gln Ser Phe Gln Lys Leu Ile Phe Lys Gly Lys 
65                  70                  75                  80  


Ser Leu Lys Glu Met Glu Xaa Pro Leu Ser Ala Leu Gly Ile Gln Asp 
                85                  90                  95      


Gly Cys Arg Val Met Leu Ile Gly Lys Lys Asn Ser Pro Gln Glu Glu 
            100                 105                 110         


Val Glu Leu Lys Lys Leu Lys His Leu Glu Lys Ser Val Glu Lys Ile 
        115                 120                 125             


Ala Asp Gln Leu Glu Glu Leu Asn Lys Glu Leu Xaa Gly Ile Gln Gln 
    130                 135                 140                 


Gly Phe Leu Pro Lys Asp Leu Gln Ala Glu Ala Leu Cys Lys Leu Asp 
145                 150                 155                 160 


Arg Arg Val Lys Ala Xaa Ile Glu Gln Phe Met Lys Ile Leu Glu Glu 
                165                 170                 175     


Ile Asp Xaa Leu Ile Leu Pro Glu Asn Phe Lys Asp Ser Arg Leu Lys 
            180                 185                 190         


Arg Lys Gly Leu Val Lys Lys Val Gln Ala Phe Leu Ala Glu Cys Asp 
        195                 200                 205             


Xaa Val Glu Gln Asn Ile Cys Gln Glu Xaa Glu Arg Leu Gln Ser Xaa 
    210                 215                 220                 


Asn Phe Ala Leu Ala Glu 
225                 230 


<210> 3828
<211> 160
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<400> 3828
Met Asn Arg Ser Gln Glu Val Xaa Arg Asp Glu Glu Ser Xaa Arg Ser 
1               5                   10                  15      


Glu Glu Val Xaa Arg Glu Glu Met Ala Ala Ala Gly Leu Xaa Val Xaa 
            20                  25                  30          


Val Xaa His Ser Asn Glu Lys His Asp Leu His Val Xaa Ser Gln Gln 
        35                  40                  45              


Gly Ser Ser Glu Pro Val Val Gln Asp Leu Ala Gln Val Val Glu Glu 
    50                  55                  60                  


Val Ile Gly Val Pro Gln Ser Phe Gln Lys Leu Ile Phe Lys Val Leu 
65                  70                  75                  80  


Gln Gln Ile Phe Ile Glu Asp Leu Leu Gly Ile Gly His Ser Gln Xaa 
                85                  90                  95      


Pro Gly Gln Val Ser Asp Leu Lys Ser Tyr Asp Asp Gly Arg Asn Leu 
            100                 105                 110         


Xaa Ile Phe Asp Glu Ala His Gly Gln Ser Ser Leu Ala Arg Lys Ile 
        115                 120                 125             


Ser Glu Gly Asn Gly Asn Xaa Val Val Ser Xaa Trp Asn Xaa Arg Trp 
    130                 135                 140                 


Leu Pro Gly His Val Asn Trp Glu Lys Glu Gln Ser Xaa Gly Arg Gly 
145                 150                 155                 160 


<210> 3829
<211> 325
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<400> 3829
Met Gln Glu Xaa Pro Ser Ser Ala Asn Gly Pro Ser Arg Glu Gly Ser 
1               5                   10                  15      


Arg Leu Pro Pro Ala Arg Glu Gly His Pro Val Tyr Pro Gln Leu Arg 
            20                  25                  30          


Pro Gly Tyr Ile Pro Ile Pro Val Leu His Glu Gly Ala Glu Asn Arg 
        35                  40                  45              


Gln Val His Pro Phe His Val Tyr Pro Gln Pro Gly Met Gln Arg Phe 
    50                  55                  60                  


Arg Xaa Glu Ala Ala Ala Ala Ala Pro Gln Arg Ser Gln Ser Pro Leu 
65                  70                  75                  80  


Arg Gly Met Pro Glu Xaa Xaa Gln Pro Asp Lys Gln Cys Gly Gln Val 
                85                  90                  95      


Ala Ala Ala Ala Ala Ala Gln Pro Pro Ala Ser His Gly Pro Glu Arg 
            100                 105                 110         


Ser Gln Ser Pro Ala Ala Ser Asp Cys Ser Ser Ser Ser Ser Ser Ala 
        115                 120                 125             


Ser Leu Pro Ser Ser Gly Arg Ser Ser Leu Gly Ser His Gln Leu Pro 
    130                 135                 140                 


Arg Gly Tyr Ile Ser Ile Pro Val Ile His Glu Gln Asn Val Xaa Arg 
145                 150                 155                 160 


Pro Ala Ala Gln Pro Ser Phe His Gln Ala Gln Lys Xaa His Tyr Pro 
                165                 170                 175     


Ala Gln Gln Gly Glu Tyr Gln Xaa His Gln Pro Val Tyr His Lys Ile 
            180                 185                 190         


Gln Gly Asp Asp Trp Glu Pro Arg Pro Leu Arg Ala Ala Ser Pro Phe 
        195                 200                 205             


Arg Ser Ser Val Gln Gly Ala Ser Ser Arg Glu Gly Ser Pro Ala Arg 
    210                 215                 220                 


Ser Ser Xaa Pro Leu His Ser Pro Ser Pro Ile Arg Val His Xaa Val 
225                 230                 235                 240 


Val Asp Arg Pro Gln Pro Met Xaa His Arg Glu Xaa Ala Pro Val Ser 
                245                 250                 255     


Gln Pro Glu Asn Lys Pro Glu Ser Lys Pro Gly Pro Val Gly Pro Glu 
            260                 265                 270         


Leu Pro Pro Gly His Ile Pro Ile Gln Val Ile Arg Lys Glu Val Asp 
        275                 280                 285             


Ser Lys Pro Val Ser Gln Lys Pro Pro Pro Pro Ser Glu Lys Val Glu 
    290                 295                 300                 


Val Lys Val Pro Pro Ala Pro Val Pro Cys Pro Pro Pro Ser Pro Gly 
305                 310                 315                 320 


Pro Ser Ala Val Pro 
                325 


<210> 3830
<211> 575
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<400> 3830
Met Ser Ala Ala Xaa His Ser Pro Met Met Gln Val Ala Ser Gly Asn 
1               5                   10                  15      


Gly Asp Arg Asp Pro Leu Pro Pro Gly Trp Glu Ile Lys Ile Asp Pro 
            20                  25                  30          


Gln Xaa Gly Trp Pro Phe Phe Val Asp His Asn Ser Arg Xaa Xaa Xaa 
        35                  40                  45              


Trp Asn Asp Pro Arg Val Pro Ser Glu Gly Pro Lys Glu Xaa Pro Ser 
    50                  55                  60                  


Ser Ala Asn Gly Pro Ser Arg Glu Gly Ser Arg Leu Pro Pro Ala Arg 
65                  70                  75                  80  


Glu Gly His Pro Val Tyr Pro Gln Leu Arg Pro Gly Tyr Ile Pro Ile 
                85                  90                  95      


Pro Val Leu His Glu Gly Ala Glu Asn Arg Gln Val His Pro Phe His 
            100                 105                 110         


Val Tyr Pro Gln Pro Gly Met Gln Arg Phe Arg Xaa Glu Ala Ala Ala 
        115                 120                 125             


Ala Ala Pro Gln Arg Ser Gln Ser Pro Leu Arg Gly Met Pro Glu Xaa 
    130                 135                 140                 


Xaa Gln Pro Asp Lys Gln Cys Gly Gln Val Ala Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Gln Pro Pro Ala Ser His Gly Pro Glu Arg Ser Gln Ser Pro Ala Ala 
                165                 170                 175     


Ser Asp Cys Ser Ser Ser Ser Ser Ser Ala Ser Leu Pro Ser Ser Gly 
            180                 185                 190         


Arg Ser Ser Leu Gly Ser His Gln Leu Pro Arg Gly Tyr Ile Ser Ile 
        195                 200                 205             


Pro Val Ile His Glu Gln Asn Val Xaa Arg Pro Ala Ala Gln Pro Ser 
    210                 215                 220                 


Phe His Gln Ala Gln Lys Xaa His Tyr Pro Ala Gln Gln Gly Glu Tyr 
225                 230                 235                 240 


Gln Xaa His Gln Pro Val Tyr His Lys Ile Gln Gly Asp Asp Trp Glu 
                245                 250                 255     


Pro Arg Pro Leu Arg Ala Ala Ser Pro Phe Arg Ser Ser Val Gln Gly 
            260                 265                 270         


Ala Ser Ser Arg Glu Gly Ser Pro Ala Arg Ser Ser Xaa Pro Leu His 
        275                 280                 285             


Ser Pro Ser Pro Ile Arg Val His Xaa Val Val Asp Arg Pro Gln Gln 
    290                 295                 300                 


Pro Met Xaa His Arg Glu Xaa Ala Pro Val Ser Gln Pro Glu Asn Lys 
305                 310                 315                 320 


Pro Glu Ser Lys Pro Gly Pro Val Gly Pro Glu Leu Pro Pro Gly His 
                325                 330                 335     


Ile Pro Ile Gln Val Ile Arg Lys Glu Val Asp Ser Lys Pro Val Ser 
            340                 345                 350         


Gln Lys Pro Pro Pro Pro Ser Glu Lys Val Glu Val Lys Val Pro Pro 
        355                 360                 365             


Ala Pro Val Pro Cys Pro Pro Pro Ser Pro Gly Pro Ser Ala Val Pro 
    370                 375                 380                 


Ser Ser Pro Lys Ser Val Ala Xaa Glu Glu Arg Ala Ala Pro Ser Xaa 
385                 390                 395                 400 


Ala Pro Ala Glu Ala Xaa Pro Pro Lys Pro Gly Glu Ala Glu Ala Pro 
                405                 410                 415     


Pro Lys His Pro Gly Val Leu Lys Val Glu Ala Ile Leu Glu Lys Val 
            420                 425                 430         


Gln Gly Leu Glu Gln Ala Val Asp Asn Phe Glu Gly Lys Lys Xaa Asp 
        435                 440                 445             


Lys Lys Tyr Leu Met Ile Glu Glu Tyr Leu Xaa Lys Glu Leu Leu Ala 
    450                 455                 460                 


Leu Asp Ser Val Asp Pro Glu Gly Arg Ala Asp Val Arg Gln Ala Arg 
465                 470                 475                 480 


Arg Asp Gly Val Arg Lys Val Gln Xaa Ile Leu Glu Lys Leu Glu Gln 
                485                 490                 495     


Lys Ala Ile Asp Val Pro Gly Gln Val Gln Val Tyr Glu Leu Gln Pro 
            500                 505                 510         


Ser Asn Leu Glu Ala Asp Gln Pro Leu Gln Ala Ile Met Glu Met Gly 
        515                 520                 525             


Ala Val Ala Ala Asp Lys Gly Lys Lys Asn Ala Gly Asn Ala Glu Asp 
    530                 535                 540                 


Pro His Xaa Glu Xaa Gln Gln Pro Glu Ala Xaa Ala Ala Ala Xaa Ser 
545                 550                 555                 560 


Asn Pro Ser Ser Met Xaa Asp Xaa Pro Gly Asn Pro Ala Ala Pro 
                565                 570                 575 


<210> 3831
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<400> 3831
Ala Tyr Tyr Ala Pro Gly Tyr Xaa Gln Xaa Ser Tyr Ser Xaa Glu Val 
1               5                   10                  15      


Pro Ser Xaa Tyr Arg Ser Ser Gly Asn Ser Pro Xaa Pro Val Ser Arg 
            20                  25                  30          


Trp Ile Tyr Pro Gln Gln Asp Cys Gln Xaa Glu Ala Pro Pro Leu Arg 
        35                  40                  45              


Gly Gln Val Pro Gly Tyr Pro Pro Ser Gln Asn Pro Gly Met Xaa Leu 
    50                  55                  60                  


Pro His Tyr Pro Tyr Gly Asp Gly Asn Arg Ser Val Pro Gln Ser Gly 
65                  70                  75                  80  


Pro Xaa Val Arg Pro Gln Glu Asp Ala Trp Ala Ser Pro Gly Ala Tyr 
                85                  90                  95      


Gly Met Gly Gly Arg Tyr Pro Trp Pro Ser Ser Ala Pro Ser Ala Pro 
            100                 105                 110         


Pro Gly Asn Leu Tyr Met Xaa Glu Ser Xaa Ser Pro Trp Pro Ser Ser 
        115                 120                 125             


Gly Ser Pro Gln Ser Pro Pro Ser Pro Pro Val Gln Gln Pro Lys Val 
    130                 135                 140                 


Gly Asp Leu Asn Val Val Pro Leu Met Cys Val 
145                 150                 155 


<210> 3832
<211> 457
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (60)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<400> 3832
Met Ser Ala Leu Arg Arg Ser Gly Tyr Gly Pro Ser Asp Gly Pro Ser 
1               5                   10                  15      


Tyr Gly Arg Tyr Tyr Gly Pro Gly Gly Gly Asp Val Pro Val His Pro 
            20                  25                  30          


Pro Pro Pro Leu Tyr Pro Leu Arg Pro Glu Pro Pro Gln Pro Pro Ile 
        35                  40                  45              


Ser Trp Arg Val Arg Gly Gly Gly Pro Ala Glu Xaa Xaa Trp Leu Gly 
    50                  55                  60                  


Glu Gly Gly Gly Gly Asp Gly Tyr Tyr Pro Ser Gly Gly Ala Trp Pro 
65                  70                  75                  80  


Glu Pro Gly Arg Ala Gly Gly Ser His Gln Glu Gln Pro Pro Tyr Pro 
                85                  90                  95      


Ser Tyr Asn Ser Asn Tyr Trp Asn Ser Xaa Ala Arg Ser Arg Ala Pro 
            100                 105                 110         


Tyr Pro Ser Xaa Tyr Pro Val Arg Pro Glu Leu Gln Gly Gln Ser Leu 
        115                 120                 125             


Asn Ser Tyr Xaa Asn Gly Ala Tyr Gly Pro Xaa Tyr Pro Pro Gly Pro 
    130                 135                 140                 


Gly Ala Asn Xaa Ala Ser Tyr Ser Gly Ala Tyr Tyr Ala Pro Gly Tyr 
145                 150                 155                 160 


Xaa Gln Xaa Ser Tyr Ser Xaa Glu Val Pro Ser Xaa Tyr Arg Ser Ser 
                165                 170                 175     


Gly Asn Ser Pro Xaa Pro Val Ser Arg Trp Ile Tyr Pro Gln Gln Asp 
            180                 185                 190         


Cys Gln Xaa Glu Ala Pro Pro Leu Arg Gly Gln Val Pro Gly Tyr Pro 
        195                 200                 205             


Pro Ser Gln Asn Pro Gly Met Xaa Leu Pro His Tyr Pro Tyr Gly Asp 
    210                 215                 220                 


Gly Asn Arg Ser Val Pro Gln Ser Gly Pro Xaa Val Arg Pro Gln Glu 
225                 230                 235                 240 


Asp Ala Trp Ala Ser Pro Gly Ala Tyr Gly Met Gly Gly Arg Tyr Pro 
                245                 250                 255     


Trp Pro Ser Ser Ala Pro Ser Ala Pro Pro Gly Asn Leu Tyr Met Xaa 
            260                 265                 270         


Glu Ser Xaa Ser Pro Trp Pro Ser Ser Gly Ser Pro Gln Ser Pro Pro 
        275                 280                 285             


Ser Pro Pro Val Gln Gln Pro Lys Asp Ser Ser Tyr Pro Tyr Ser Gln 
    290                 295                 300                 


Ser Asp Gln Ser Met Asn Arg His Asn Phe Pro Cys Ser Val His Gln 
305                 310                 315                 320 


Tyr Glu Ser Ser Gly Xaa Val Asn Asn Asp Asp Ser Asp Leu Leu Asp 
                325                 330                 335     


Ser Gln Val Gln Tyr Ser Ala Glu Pro Gln Leu Tyr Gly Asn Ala Xaa 
            340                 345                 350         


Ser Asp His Pro Asn Asn Gln Asp Gln Ser Ser Ser Leu Pro Glu Glu 
        355                 360                 365             


Cys Val Pro Ser Asp Glu Ser Xaa Pro Pro Ser Ile Lys Lys Ile Ile 
    370                 375                 380                 


His Val Leu Glu Lys Val Gln Tyr Leu Glu Gln Glu Val Glu Glu Phe 
385                 390                 395                 400 


Val Gly Lys Lys Xaa Asp Lys Ala Tyr Trp Leu Leu Glu Glu Met Leu 
                405                 410                 415     


Xaa Lys Glu Leu Leu Glu Leu Asp Ser Val Glu Xaa Gly Gly Gln Asp 
            420                 425                 430         


Ser Val Arg Gln Ala Arg Lys Glu Ala Val Cys Lys Ile Gln Ala Ile 
        435                 440                 445             


Leu Glu Lys Leu Glu Lys Lys Gly Leu 
    450                 455         


<210> 3833
<211> 421
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (60)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<400> 3833
Met Ser Ala Leu Arg Arg Ser Gly Tyr Gly Pro Ser Asp Gly Pro Ser 
1               5                   10                  15      


Tyr Gly Arg Tyr Tyr Gly Pro Gly Gly Gly Asp Val Pro Val His Pro 
            20                  25                  30          


Pro Pro Pro Leu Tyr Pro Leu Arg Pro Glu Pro Pro Gln Pro Pro Ile 
        35                  40                  45              


Ser Trp Arg Val Arg Gly Gly Gly Pro Ala Glu Xaa Xaa Trp Leu Gly 
    50                  55                  60                  


Glu Gly Gly Gly Gly Asp Gly Tyr Tyr Pro Ser Gly Gly Ala Trp Pro 
65                  70                  75                  80  


Glu Pro Gly Arg Ala Gly Gly Ser His Gln Ser Leu Asn Ser Tyr Xaa 
                85                  90                  95      


Asn Gly Ala Tyr Gly Pro Xaa Tyr Pro Pro Gly Pro Gly Ala Asn Xaa 
            100                 105                 110         


Ala Ser Tyr Ser Gly Ala Tyr Tyr Ala Pro Gly Tyr Xaa Gln Xaa Ser 
        115                 120                 125             


Tyr Ser Xaa Glu Val Pro Ser Xaa Tyr Arg Ser Ser Gly Asn Ser Pro 
    130                 135                 140                 


Xaa Pro Val Ser Arg Trp Ile Tyr Pro Gln Gln Asp Cys Gln Xaa Glu 
145                 150                 155                 160 


Ala Pro Pro Leu Arg Gly Gln Val Pro Gly Tyr Pro Pro Ser Gln Asn 
                165                 170                 175     


Pro Gly Met Xaa Leu Pro His Tyr Pro Tyr Gly Asp Gly Asn Arg Ser 
            180                 185                 190         


Val Pro Gln Ser Gly Pro Xaa Val Arg Pro Gln Glu Asp Ala Trp Ala 
        195                 200                 205             


Ser Pro Gly Ala Tyr Gly Met Gly Gly Arg Tyr Pro Trp Pro Ser Ser 
    210                 215                 220                 


Ala Pro Ser Ala Pro Pro Gly Asn Leu Tyr Met Xaa Glu Ser Xaa Ser 
225                 230                 235                 240 


Pro Trp Pro Ser Ser Gly Ser Pro Gln Ser Pro Pro Ser Pro Pro Val 
                245                 250                 255     


Gln Gln Pro Lys Asp Ser Ser Tyr Pro Tyr Ser Gln Ser Asp Gln Ser 
            260                 265                 270         


Met Asn Arg His Asn Phe Pro Cys Ser Val His Gln Tyr Glu Ser Ser 
        275                 280                 285             


Gly Xaa Val Asn Asn Asp Asp Ser Asp Leu Leu Asp Ser Gln Val Gln 
    290                 295                 300                 


Tyr Ser Ala Glu Pro Gln Leu Tyr Gly Asn Ala Xaa Ser Asp His Pro 
305                 310                 315                 320 


Asn Asn Gln Asp Gln Ser Ser Ser Leu Pro Glu Glu Cys Val Pro Ser 
                325                 330                 335     


Asp Glu Ser Xaa Pro Pro Ser Ile Lys Lys Ile Ile His Val Leu Glu 
            340                 345                 350         


Lys Val Gln Tyr Leu Glu Gln Glu Val Glu Glu Phe Val Gly Lys Lys 
        355                 360                 365             


Xaa Asp Lys Ala Tyr Trp Leu Leu Glu Glu Met Leu Xaa Lys Glu Leu 
    370                 375                 380                 


Leu Glu Leu Asp Ser Val Glu Xaa Gly Gly Gln Asp Ser Val Arg Gln 
385                 390                 395                 400 


Ala Arg Lys Glu Ala Val Cys Lys Ile Gln Ala Ile Leu Glu Lys Leu 
                405                 410                 415     


Glu Lys Lys Gly Leu 
            420     


<210> 3834
<211> 211
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<400> 3834
Met Asp Met Gly Asn Gln His Pro Ser Ile Ser Arg Leu Gln Glu Ile 
1               5                   10                  15      


Gln Lys Glu Val Lys Ser Val Glu Gln Gln Val Ile Gly Phe Ser Gly 
            20                  25                  30          


Leu Ser Asp Asp Lys Asn Tyr Lys Lys Leu Glu Arg Ile Leu Xaa Lys 
        35                  40                  45              


Gln Leu Phe Glu Ile Asp Ser Val Asp Xaa Glu Gly Lys Gly Asp Ile 
    50                  55                  60                  


Gln Gln Ala Arg Lys Arg Ala Ala Gln Glu Xaa Glu Arg Leu Leu Lys 
65                  70                  75                  80  


Glu Leu Glu Gln Asn Ala Asn His Pro His Arg Ile Glu Ile Gln Asn 
                85                  90                  95      


Ile Phe Glu Glu Ala Gln Ser Leu Val Arg Glu Lys Ile Val Pro Phe 
            100                 105                 110         


Tyr Asn Gly Gly Asn Cys Val Xaa Asp Glu Phe Glu Glu Gly Ile Gln 
        115                 120                 125             


Asp Ile Ile Leu Arg Leu Xaa His Val Lys Xaa Gly Gly Lys Ile Ser 
    130                 135                 140                 


Leu Arg Lys Ala Arg Tyr His Xaa Leu Xaa Lys Ile Cys Ala Val Gln 
145                 150                 155                 160 


Glu Ile Ile Glu Asp Cys Met Lys Lys Gln Pro Ser Leu Pro Leu Ser 
                165                 170                 175     


Glu Asp Ala His Pro Ser Val Ala Lys Ile Asn Phe Val Met Cys Glu 
            180                 185                 190         


Val Asn Lys Ala Arg Gly Val Leu Ile Ala Leu Leu Met Gly Val Asn 
        195                 200                 205             


Asn Asn Glu 
    210     


<210> 3835
<211> 447
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<400> 3835
Met Asp Met Gly Asn Gln His Pro Ser Ile Ser Arg Leu Gln Glu Ile 
1               5                   10                  15      


Gln Lys Glu Val Lys Ser Val Glu Gln Gln Val Ile Gly Phe Ser Gly 
            20                  25                  30          


Leu Ser Asp Asp Lys Asn Tyr Lys Lys Leu Glu Arg Ile Leu Xaa Lys 
        35                  40                  45              


Gln Leu Phe Glu Ile Asp Ser Val Asp Xaa Glu Gly Lys Gly Asp Ile 
    50                  55                  60                  


Gln Gln Ala Arg Lys Arg Ala Ala Gln Glu Xaa Glu Arg Leu Leu Lys 
65                  70                  75                  80  


Glu Leu Glu Gln Asn Ala Asn His Pro His Arg Ile Glu Ile Gln Asn 
                85                  90                  95      


Ile Phe Glu Glu Ala Gln Ser Leu Val Arg Glu Lys Ile Val Pro Phe 
            100                 105                 110         


Tyr Asn Gly Gly Asn Cys Val Xaa Asp Glu Phe Glu Glu Gly Ile Gln 
        115                 120                 125             


Asp Ile Ile Leu Arg Leu Xaa His Val Lys Xaa Gly Gly Lys Ile Ser 
    130                 135                 140                 


Leu Arg Lys Ala Arg Tyr His Xaa Leu Xaa Lys Ile Cys Ala Val Gln 
145                 150                 155                 160 


Glu Ile Ile Glu Asp Cys Met Lys Lys Gln Pro Ser Leu Pro Leu Ser 
                165                 170                 175     


Glu Asp Ala His Pro Ser Val Ala Lys Ile Asn Phe Val Met Cys Glu 
            180                 185                 190         


Val Asn Lys Ala Arg Gly Val Leu Ile Ala Leu Leu Met Gly Val Asn 
        195                 200                 205             


Asn Asn Glu Xaa Cys Arg His Leu Ser Cys Val Leu Ser Gly Leu Ile 
    210                 215                 220                 


Ala Asp Leu Asp Ala Leu Asp Val Cys Gly Arg Xaa Glu Ile Arg Asn 
225                 230                 235                 240 


Tyr Arg Arg Glu Val Val Glu Asp Ile Asn Lys Leu Leu Lys Tyr Leu 
                245                 250                 255     


Asp Leu Glu Glu Glu Ala Asp Xaa Xaa Lys Ala Phe Asp Leu Arg Gln 
            260                 265                 270         


Asn His Ser Ile Leu Lys Ile Glu Lys Val Leu Lys Arg Met Arg Glu 
        275                 280                 285             


Ile Lys Asn Glu Leu Leu Gln Ala Gln Asn Pro Ser Glu Leu Tyr Leu 
    290                 295                 300                 


Ser Ser Lys Xaa Glu Leu Gln Gly Leu Ile Gly Gln Leu Asp Glu Val 
305                 310                 315                 320 


Ser Leu Glu Lys Asn Pro Cys Ile Arg Glu Ala Arg Arg Arg Ala Val 
                325                 330                 335     


Ile Glu Val Gln Xaa Leu Ile Xaa Tyr Ile Asp Leu Lys Glu Ala Leu 
            340                 345                 350         


Glu Lys Arg Lys Leu Phe Ala Cys Glu Glu His Pro Ser His Lys Ala 
        355                 360                 365             


Val Trp Asn Val Leu Gly Asn Leu Ser Glu Ile Gln Gly Glu Val Leu 
    370                 375                 380                 


Ser Phe Asp Gly Asn Arg Xaa Asp Lys Asn Tyr Ile Arg Leu Glu Glu 
385                 390                 395                 400 


Leu Leu Xaa Lys Gln Leu Leu Ala Leu Asp Ala Val Asp Pro Gln Gly 
                405                 410                 415     


Glu Glu Lys Cys Lys Ala Ala Arg Lys Gln Ala Val Arg Leu Ala Gln 
            420                 425                 430         


Asn Ile Leu Ser Tyr Leu Asp Leu Lys Ser Asp Glu Trp Glu Tyr 
        435                 440                 445         


<210> 3836
<211> 488
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<400> 3836
Met Arg Phe His Trp Leu Pro Xaa Leu Ser Glu Pro Phe Asp Arg Asn 
1               5                   10                  15      


Gln Glu Leu Glu Xaa Cys Ile Arg Pro Leu Trp Xaa Pro Ser Gly Ser 
            20                  25                  30          


Ala Cys Glu Xaa Glu His Asn Lys Ser Met Asp Met Gly Asn Gln His 
        35                  40                  45              


Pro Ser Ile Ser Arg Leu Gln Glu Ile Gln Lys Glu Val Lys Ser Val 
    50                  55                  60                  


Glu Gln Gln Val Ile Gly Phe Ser Gly Leu Ser Asp Asp Lys Asn Tyr 
65                  70                  75                  80  


Lys Lys Leu Glu Arg Ile Leu Xaa Lys Gln Leu Phe Glu Ile Asp Ser 
                85                  90                  95      


Val Asp Xaa Glu Gly Lys Gly Asp Ile Gln Gln Ala Arg Lys Arg Ala 
            100                 105                 110         


Ala Gln Glu Xaa Glu Arg Leu Leu Lys Glu Leu Glu Gln Asn Ala Asn 
        115                 120                 125             


His Pro His Arg Ile Glu Ile Gln Asn Ile Phe Glu Glu Ala Gln Ser 
    130                 135                 140                 


Leu Val Arg Glu Lys Ile Val Pro Phe Tyr Asn Gly Gly Asn Cys Val 
145                 150                 155                 160 


Xaa Asp Glu Phe Glu Glu Gly Ile Gln Asp Ile Ile Leu Arg Leu Xaa 
                165                 170                 175     


His Val Lys Xaa Gly Gly Lys Ile Ser Leu Arg Lys Ala Arg Tyr His 
            180                 185                 190         


Xaa Leu Xaa Lys Ile Cys Ala Val Gln Glu Ile Ile Glu Asp Cys Met 
        195                 200                 205             


Lys Lys Gln Pro Ser Leu Pro Leu Ser Glu Asp Ala His Pro Ser Val 
    210                 215                 220                 


Ala Lys Ile Asn Phe Val Met Cys Glu Val Asn Lys Ala Arg Gly Val 
225                 230                 235                 240 


Leu Ile Ala Leu Leu Met Gly Val Asn Asn Asn Glu Xaa Cys Arg His 
                245                 250                 255     


Leu Ser Cys Val Leu Ser Gly Leu Ile Ala Asp Leu Asp Ala Leu Asp 
            260                 265                 270         


Val Cys Gly Arg Xaa Glu Ile Arg Asn Tyr Arg Arg Glu Val Val Glu 
        275                 280                 285             


Asp Ile Asn Lys Leu Leu Lys Tyr Leu Asp Leu Glu Glu Glu Ala Asp 
    290                 295                 300                 


Xaa Xaa Lys Ala Phe Asp Leu Arg Gln Asn His Ser Ile Leu Lys Ile 
305                 310                 315                 320 


Glu Lys Val Leu Lys Arg Met Arg Glu Ile Lys Asn Glu Leu Leu Gln 
                325                 330                 335     


Ala Gln Asn Pro Ser Glu Leu Tyr Leu Ser Ser Lys Xaa Glu Leu Gln 
            340                 345                 350         


Gly Leu Ile Gly Gln Leu Asp Glu Val Ser Leu Glu Lys Asn Pro Cys 
        355                 360                 365             


Ile Arg Glu Ala Arg Arg Arg Ala Val Ile Glu Val Gln Xaa Leu Ile 
    370                 375                 380                 


Xaa Tyr Ile Asp Leu Lys Glu Ala Leu Glu Lys Arg Lys Leu Phe Ala 
385                 390                 395                 400 


Cys Glu Glu His Pro Ser His Lys Ala Val Trp Asn Val Leu Gly Asn 
                405                 410                 415     


Leu Ser Glu Ile Gln Gly Glu Val Leu Ser Phe Asp Gly Asn Arg Xaa 
            420                 425                 430         


Asp Lys Asn Tyr Ile Arg Leu Glu Glu Leu Leu Xaa Lys Gln Leu Leu 
        435                 440                 445             


Ala Leu Asp Ala Val Asp Pro Gln Gly Glu Glu Lys Cys Lys Ala Ala 
    450                 455                 460                 


Arg Lys Gln Ala Val Arg Leu Ala Gln Asn Ile Leu Ser Tyr Leu Asp 
465                 470                 475                 480 


Leu Lys Ser Asp Glu Trp Glu Tyr 
                485             


<210> 3837
<211> 158
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<400> 3837
Met Glu Pro Asn Asp Ser Xaa Ser Xaa Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Xaa Leu Asp Ser Gln Xaa Arg Xaa Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Xaa His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Xaa Gly Ser Ala Ser Ala Xaa His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Xaa Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Xaa Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile 
145                 150                 155             


<210> 3838
<211> 197
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<400> 3838
Met Glu Pro Asn Asp Ser Xaa Ser Xaa Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Xaa Leu Asp Ser Gln Xaa Arg Xaa Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Xaa His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Xaa Gly Ser Ala Ser Ala Xaa His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Xaa Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Xaa Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
145                 150                 155                 160 


Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                165                 170                 175     


Gln Xaa Leu Leu Ser Arg Met Glu Cys Arg Gly Gly Pro Gln Pro Gln 
            180                 185                 190         


His Ser Gln Pro Pro 
        195         


<210> 3839
<211> 258
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<400> 3839
Met Glu Pro Asn Asp Ser Xaa Ser Xaa Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Xaa Leu Asp Ser Gln Xaa Arg Xaa Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Xaa His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Xaa Gly Ser Ala Ser Ala Xaa His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Xaa Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Xaa Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
145                 150                 155                 160 


Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                165                 170                 175     


Gln Xaa Leu Leu Ser Arg Met Glu Cys Arg Gly Gly Pro Gln Pro Gln 
            180                 185                 190         


His Ser Gln Pro Pro Pro Gln Pro Pro Ala Val Xaa Pro Glu Pro Val 
        195                 200                 205             


Ala Leu Ser Ser Gln Xaa Ser Glu Pro Val Glu Ser Glu Ala Pro Pro 
    210                 215                 220                 


Arg Glu Pro Met Glu Ala Glu Glu Val Glu Glu Arg Ala Pro Ala Gln 
225                 230                 235                 240 


Asn Pro Glu Leu Xaa Pro Gly Pro Ala Pro Ala Gly Pro Xaa Pro Ala 
                245                 250                 255     


Pro Glu 
        


<210> 3840
<211> 259
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<400> 3840
Met Glu Pro Asn Asp Ser Xaa Ser Xaa Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Xaa Leu Asp Ser Gln Xaa Arg Xaa Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Xaa His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Xaa Gly Ser Ala Ser Ala Xaa His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Xaa Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Xaa Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
145                 150                 155                 160 


Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                165                 170                 175     


Gln Xaa Leu Leu Ser Arg Met Glu Cys Arg Gly Gly Pro Gln Pro Gln 
            180                 185                 190         


His Ser Gln Pro Pro Pro Gln Pro Pro Ala Val Xaa Pro Glu Pro Val 
        195                 200                 205             


Ala Leu Ser Ser Gln Xaa Ser Glu Pro Val Glu Ser Glu Ala Pro Pro 
    210                 215                 220                 


Arg Glu Pro Met Glu Ala Glu Glu Val Glu Glu Arg Ala Pro Ala Gln 
225                 230                 235                 240 


Asn Pro Glu Leu Xaa Pro Gly Pro Ala Pro Ala Gly Pro Xaa Pro Ala 
                245                 250                 255     


Pro Glu Xaa 
            


<210> 3841
<211> 262
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<400> 3841
Met Glu Pro Asn Asp Ser Xaa Ser Xaa Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Xaa Leu Asp Ser Gln Xaa Arg Xaa Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Xaa His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Xaa Gly Ser Ala Ser Ala Xaa His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Xaa Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Xaa Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
145                 150                 155                 160 


Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                165                 170                 175     


Gln Xaa Leu Leu Ser Arg Met Glu Cys Arg Gly Gly Pro Gln Pro Gln 
            180                 185                 190         


His Ser Gln Pro Pro Pro Gln Pro Pro Ala Val Xaa Pro Glu Pro Val 
        195                 200                 205             


Ala Leu Ser Ser Gln Xaa Ser Glu Pro Val Glu Ser Glu Ala Pro Pro 
    210                 215                 220                 


Arg Glu Pro Met Glu Ala Glu Glu Val Glu Glu Arg Ala Pro Ala Gln 
225                 230                 235                 240 


Asn Pro Glu Leu Xaa Pro Gly Pro Ala Pro Ala Gly Pro Xaa Pro Ala 
                245                 250                 255     


Pro Glu Xaa Asn Ala Pro 
            260         


<210> 3842
<211> 515
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<400> 3842
Met Glu Pro Asn Asp Ser Xaa Ser Xaa Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Xaa Leu Asp Ser Gln Xaa Arg Xaa Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Xaa His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Xaa Gly Ser Ala Ser Ala Xaa His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Xaa Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Xaa Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
145                 150                 155                 160 


Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                165                 170                 175     


Gln Xaa Leu Leu Ser Arg Met Glu Cys Arg Gly Gly Pro Gln Pro Gln 
            180                 185                 190         


His Ser Gln Pro Pro Pro Gln Pro Pro Ala Val Xaa Pro Glu Pro Val 
        195                 200                 205             


Ala Leu Ser Ser Gln Xaa Ser Glu Pro Val Glu Ser Glu Ala Pro Pro 
    210                 215                 220                 


Arg Glu Pro Met Glu Ala Glu Glu Val Glu Glu Arg Ala Pro Ala Gln 
225                 230                 235                 240 


Asn Pro Glu Leu Xaa Pro Gly Pro Ala Pro Ala Gly Pro Xaa Pro Ala 
                245                 250                 255     


Pro Glu Xaa Asn Ala Pro Asn His Pro Ser Pro Ala Glu Tyr Val Glu 
            260                 265                 270         


Val Leu Gln Glu Leu Gln Arg Leu Glu Ser Arg Leu Gln Pro Phe Leu 
        275                 280                 285             


Gln Arg Tyr Tyr Glu Val Leu Gly Ala Ala Ala Xaa Xaa Asp Tyr Asn 
    290                 295                 300                 


Asn Asn His Glu Gly Arg Glu Glu Asp Gln Arg Leu Ile Asn Leu Val 
305                 310                 315                 320 


Gly Glu Ser Leu Arg Leu Leu Gly Asn Xaa Phe Val Ala Leu Ser Asp 
                325                 330                 335     


Leu Arg Cys Asn Leu Ala Cys Xaa Pro Pro Arg His Leu His Val Val 
            340                 345                 350         


Arg Pro Met Ser His Tyr Xaa Xaa Pro Met Val Leu Gln Gln Ala Ala 
        355                 360                 365             


Ile Pro Ile Gln Ile Asn Val Gly Xaa Xaa Val Xaa Met Xaa Gly Asn 
    370                 375                 380                 


Gly Xaa Arg Pro Pro Pro Xaa Pro Asn Ala Glu Ala Pro Pro Pro Gly 
385                 390                 395                 400 


Pro Gly Gln Ala Ser Ser Val Ala Pro Ser Ser Xaa Asn Val Glu Ser 
                405                 410                 415     


Ser Ala Glu Gly Ala Pro Pro Pro Gly Pro Ala Pro Pro Pro Ala Xaa 
            420                 425                 430         


Ser His Pro Arg Val Ile Arg Ile Ser His Gln Ser Val Glu Pro Val 
        435                 440                 445             


Val Met Met His Met Asn Ile Gln Asp Ser Gly Xaa Gln Pro Gly Gly 
    450                 455                 460                 


Val Pro Ser Ala Pro Xaa Gly Pro Leu Gly Pro Pro Gly His Gly Gln 
465                 470                 475                 480 


Xaa Leu Gly Ser Xaa Leu Ile Gln Leu Pro Ser Leu Pro Pro Glu Phe 
                485                 490                 495     


Met His Ala Val Ala His Gln Ile Xaa His Gln Ala Met Val Ala Ala 
            500                 505                 510         


Val Ala Ser 
        515 


<210> 3843
<211> 743
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<400> 3843
Met Glu Pro Asn Asp Ser Xaa Ser Xaa Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Xaa Leu Asp Ser Gln Xaa Arg Xaa Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Xaa His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Xaa Gly Ser Ala Ser Ala Xaa His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Xaa Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Xaa Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
145                 150                 155                 160 


Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                165                 170                 175     


Gln Xaa Leu Leu Ser Arg Met Glu Cys Arg Gly Gly Pro Gln Pro Gln 
            180                 185                 190         


His Ser Gln Pro Pro Pro Gln Pro Pro Ala Val Xaa Pro Glu Pro Val 
        195                 200                 205             


Ala Leu Ser Ser Gln Xaa Ser Glu Pro Val Glu Ser Glu Ala Pro Pro 
    210                 215                 220                 


Arg Glu Pro Met Glu Ala Glu Glu Val Glu Glu Arg Ala Pro Ala Gln 
225                 230                 235                 240 


Asn Pro Glu Leu Xaa Pro Gly Pro Ala Pro Ala Gly Pro Xaa Pro Ala 
                245                 250                 255     


Pro Glu Xaa Asn Ala Pro Asn His Pro Ser Pro Ala Glu Tyr Val Glu 
            260                 265                 270         


Val Leu Gln Glu Leu Gln Arg Leu Glu Ser Arg Leu Gln Pro Phe Leu 
        275                 280                 285             


Gln Arg Tyr Tyr Glu Val Leu Gly Ala Ala Ala Xaa Xaa Asp Tyr Asn 
    290                 295                 300                 


Asn Asn His Glu Gly Arg Glu Glu Asp Gln Arg Leu Ile Asn Leu Val 
305                 310                 315                 320 


Gly Glu Ser Leu Arg Leu Leu Gly Asn Xaa Phe Val Ala Leu Ser Asp 
                325                 330                 335     


Leu Arg Cys Asn Leu Ala Cys Xaa Pro Pro Arg His Leu His Val Val 
            340                 345                 350         


Arg Pro Met Ser His Tyr Xaa Xaa Pro Met Val Leu Gln Gln Ala Ala 
        355                 360                 365             


Ile Pro Ile Gln Ile Asn Val Gly Xaa Xaa Val Xaa Met Xaa Gly Asn 
    370                 375                 380                 


Gly Xaa Arg Pro Pro Pro Xaa Pro Asn Ala Glu Ala Pro Pro Pro Gly 
385                 390                 395                 400 


Pro Gly Gln Ala Ser Ser Val Ala Pro Ser Ser Xaa Asn Val Glu Ser 
                405                 410                 415     


Ser Ala Glu Gly Ala Pro Pro Pro Gly Pro Ala Pro Pro Pro Ala Xaa 
            420                 425                 430         


Ser His Pro Arg Val Ile Arg Ile Ser His Gln Ser Val Glu Pro Val 
        435                 440                 445             


Val Met Met His Met Asn Ile Gln Asp Ser Gly Xaa Gln Pro Gly Gly 
    450                 455                 460                 


Val Pro Ser Ala Pro Xaa Gly Pro Leu Gly Pro Pro Gly His Gly Gln 
465                 470                 475                 480 


Xaa Leu Gly Ser Xaa Leu Ile Gln Leu Pro Ser Leu Pro Pro Glu Phe 
                485                 490                 495     


Met His Ala Val Ala His Gln Ile Xaa His Gln Ala Met Val Ala Ala 
            500                 505                 510         


Val Ala Ser Ala Ala Ala Gly Gln Gln Val Pro Gly Phe Pro Xaa Ala 
        515                 520                 525             


Pro Xaa Arg Val Val Ile Ala Arg Pro Xaa Pro Pro Gln Ala Arg Pro 
    530                 535                 540                 


Ser His Pro Gly Gly Pro Pro Val Ser Gly Xaa Leu Gln Gly Ala Gly 
545                 550                 555                 560 


Leu Gly Xaa Asn Ala Ser Leu Ala Gln Met Val Ser Gly Leu Val Gly 
                565                 570                 575     


Gln Leu Leu Met Gln Pro Val Leu Val Ala Gln Gly Xaa Pro Gly Met 
            580                 585                 590         


Ala Pro Pro Pro Ala Pro Ala Xaa Ala Ser Ala Ser Ala Gly Xaa Xaa 
        595                 600                 605             


Asn Xaa Ala Xaa Xaa Ala Gly Pro Ala Pro Gly Gly Pro Ala Gln Pro 
    610                 615                 620                 


Pro Pro Xaa Pro Gln Pro Ser Met Ala Asp Leu Gln Phe Ser Gln Leu 
625                 630                 635                 640 


Leu Gly Asn Leu Leu Gly Pro Ala Gly Pro Gly Ala Gly Gly Ser Gly 
                645                 650                 655     


Val Ala Ser Pro Xaa Ile Xaa Val Ala Met Pro Gly Val Pro Ala Phe 
            660                 665                 670         


Leu Gln Gly Met Xaa Asp Phe Leu Gln Ala Xaa Gln Xaa Ala Pro Pro 
        675                 680                 685             


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro Glu Gln Gln Xaa 
    690                 695                 700                 


Met Pro Pro Pro Gly Ser Pro Ser Gly Gly Ala Gly Ser Pro Gly Gly 
705                 710                 715                 720 


Leu Gly Leu Glu Ser Leu Ser Pro Glu Phe Phe Xaa Ser Val Val Gln 
                725                 730                 735     


Gly Val Leu Ser Ser Leu Leu 
            740             


<210> 3844
<211> 743
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<400> 3844
Met Glu Pro Asn Asp Ser Xaa Ser Xaa Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Xaa Leu Asp Ser Gln Xaa Arg Xaa Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Xaa His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Xaa Gly Ser Ala Ser Ala Xaa His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Xaa Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Xaa Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
145                 150                 155                 160 


Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                165                 170                 175     


Gln Xaa Leu Leu Ser Arg Met Glu Cys Arg Gly Gly Pro Gln Pro Gln 
            180                 185                 190         


His Ser Gln Pro Pro Pro Gln Pro Pro Ala Val Xaa Pro Glu Pro Val 
        195                 200                 205             


Ala Leu Ser Ser Gln Xaa Ser Glu Pro Val Glu Ser Glu Ala Pro Pro 
    210                 215                 220                 


Arg Glu Pro Met Glu Ala Glu Glu Val Glu Glu Arg Ala Pro Ala Gln 
225                 230                 235                 240 


Asn Pro Glu Leu Xaa Pro Gly Pro Ala Pro Ala Gly Pro Xaa Pro Ala 
                245                 250                 255     


Pro Glu Xaa Asn Ala Pro Asn His Pro Ser Pro Ala Glu Tyr Val Glu 
            260                 265                 270         


Val Leu Gln Glu Leu Gln Arg Leu Glu Ser Arg Leu Gln Pro Phe Leu 
        275                 280                 285             


Gln Arg Tyr Tyr Glu Val Leu Gly Ala Ala Ala Xaa Xaa Asp Tyr Asn 
    290                 295                 300                 


Asn Asn His Glu Gly Arg Glu Glu Asp Gln Arg Leu Ile Asn Leu Val 
305                 310                 315                 320 


Gly Glu Ser Leu Arg Leu Leu Gly Asn Xaa Phe Val Ala Leu Ser Asp 
                325                 330                 335     


Leu Arg Cys Asn Leu Ala Cys Xaa Pro Pro Arg His Leu His Val Val 
            340                 345                 350         


Arg Pro Met Ser His Tyr Xaa Xaa Pro Met Val Leu Gln Gln Ala Ala 
        355                 360                 365             


Ile Pro Ile Gln Ile Asn Val Gly Xaa Xaa Val Xaa Met Xaa Gly Asn 
    370                 375                 380                 


Gly Xaa Arg Pro Pro Pro Xaa Pro Asn Ala Glu Ala Pro Pro Pro Gly 
385                 390                 395                 400 


Pro Gly Gln Ala Ser Ser Val Ala Pro Ser Ser Xaa Asn Val Glu Ser 
                405                 410                 415     


Ser Ala Glu Gly Ala Pro Pro Pro Gly Pro Ala Pro Pro Pro Ala Xaa 
            420                 425                 430         


Ser His Pro Arg Val Ile Arg Ile Ser His Gln Ser Val Glu Pro Val 
        435                 440                 445             


Val Met Met His Met Asn Ile Gln Asp Ser Gly Xaa Gln Pro Gly Gly 
    450                 455                 460                 


Val Pro Ser Ala Pro Xaa Gly Pro Leu Gly Pro Pro Gly His Gly Gln 
465                 470                 475                 480 


Xaa Leu Gly Ser Xaa Leu Ile Gln Leu Pro Ser Leu Pro Pro Glu Phe 
                485                 490                 495     


Met His Ala Val Ala His Gln Ile Xaa His Gln Ala Met Val Ala Ala 
            500                 505                 510         


Val Ala Ser Ala Ala Ala Gly Gln Gln Val Pro Gly Phe Pro Xaa Ala 
        515                 520                 525             


Pro Xaa Arg Val Val Ile Ala Arg Pro Xaa Pro Pro Gln Ala Arg Pro 
    530                 535                 540                 


Ser His Pro Gly Gly Pro Pro Val Ser Gly Xaa Leu Gln Gly Ala Gly 
545                 550                 555                 560 


Leu Gly Xaa Asn Ala Ser Leu Ala Gln Met Val Ser Gly Leu Val Gly 
                565                 570                 575     


Gln Leu Leu Met Gln Pro Val Leu Val Ala Gln Gly Xaa Pro Gly Met 
            580                 585                 590         


Ala Pro Pro Pro Ala Pro Ala Xaa Ala Ser Ala Ser Ala Gly Xaa Xaa 
        595                 600                 605             


Asn Xaa Ala Xaa Xaa Ala Gly Pro Ala Pro Gly Gly Pro Ala Gln Pro 
    610                 615                 620                 


Pro Pro Xaa Pro Gln Pro Ser Met Ala Asp Leu Gln Phe Ser Gln Leu 
625                 630                 635                 640 


Leu Gly Asn Leu Leu Gly Pro Ala Gly Pro Gly Ala Gly Gly Pro Gly 
                645                 650                 655     


Val Ala Ser Pro Xaa Ile Xaa Val Ala Met Pro Gly Val Pro Ala Phe 
            660                 665                 670         


Leu Gln Gly Met Xaa Asp Phe Leu Gln Ala Xaa Gln Xaa Ala Pro Pro 
        675                 680                 685             


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro Glu Gln Gln Xaa 
    690                 695                 700                 


Met Pro Pro Pro Gly Ser Pro Ser Gly Gly Ala Gly Ser Pro Gly Gly 
705                 710                 715                 720 


Leu Gly Leu Glu Ser Leu Ser Pro Glu Phe Phe Xaa Ser Val Val Gln 
                725                 730                 735     


Gly Val Leu Ser Ser Leu Leu 
            740             


<210> 3845
<211> 903
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(784)
<223> Selenocysteine

<400> 3845
Met Glu Pro Asn Asp Ser Xaa Ser Xaa Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Xaa Leu Asp Ser Gln Xaa Arg Xaa Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Xaa His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Xaa Gly Ser Ala Ser Ala Xaa His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Xaa Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Xaa Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
145                 150                 155                 160 


Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                165                 170                 175     


Gln Xaa Leu Leu Ser Arg Met Glu Cys Arg Gly Gly Pro Gln Pro Gln 
            180                 185                 190         


His Ser Gln Pro Pro Pro Gln Pro Pro Ala Val Xaa Pro Glu Pro Val 
        195                 200                 205             


Ala Leu Ser Ser Gln Xaa Ser Glu Pro Val Glu Ser Glu Ala Pro Pro 
    210                 215                 220                 


Arg Glu Pro Met Glu Ala Glu Glu Val Glu Glu Arg Ala Pro Ala Gln 
225                 230                 235                 240 


Asn Pro Glu Leu Xaa Pro Gly Pro Ala Pro Ala Gly Pro Xaa Pro Ala 
                245                 250                 255     


Pro Glu Xaa Asn Ala Pro Asn His Pro Ser Pro Ala Glu Tyr Val Glu 
            260                 265                 270         


Val Leu Gln Glu Leu Gln Arg Leu Glu Ser Arg Leu Gln Pro Phe Leu 
        275                 280                 285             


Gln Arg Tyr Tyr Glu Val Leu Gly Ala Ala Ala Xaa Xaa Asp Tyr Asn 
    290                 295                 300                 


Asn Asn His Glu Gly Arg Glu Glu Asp Gln Arg Leu Ile Asn Leu Val 
305                 310                 315                 320 


Gly Glu Ser Leu Arg Leu Leu Gly Asn Xaa Phe Val Ala Leu Ser Asp 
                325                 330                 335     


Leu Arg Cys Asn Leu Ala Cys Xaa Pro Pro Arg His Leu His Val Val 
            340                 345                 350         


Arg Pro Met Ser His Tyr Xaa Xaa Pro Met Val Leu Gln Gln Ala Ala 
        355                 360                 365             


Ile Pro Ile Gln Ile Asn Val Gly Xaa Xaa Val Xaa Met Xaa Gly Asn 
    370                 375                 380                 


Gly Xaa Arg Pro Pro Pro Xaa Pro Asn Ala Glu Ala Pro Pro Pro Gly 
385                 390                 395                 400 


Pro Gly Gln Ala Ser Ser Val Ala Pro Ser Ser Xaa Asn Val Glu Ser 
                405                 410                 415     


Ser Ala Glu Gly Ala Pro Pro Pro Gly Pro Ala Pro Pro Pro Ala Xaa 
            420                 425                 430         


Ser His Pro Arg Val Ile Arg Ile Ser His Gln Ser Val Glu Pro Val 
        435                 440                 445             


Val Met Met His Met Asn Ile Gln Asp Ser Gly Xaa Gln Pro Gly Gly 
    450                 455                 460                 


Val Pro Ser Ala Pro Xaa Gly Pro Leu Gly Pro Pro Gly His Gly Gln 
465                 470                 475                 480 


Xaa Leu Gly Gln Gln Val Pro Gly Phe Pro Xaa Ala Pro Xaa Arg Val 
                485                 490                 495     


Val Ile Ala Arg Pro Xaa Pro Pro Gln Ala Arg Pro Ser His Pro Gly 
            500                 505                 510         


Gly Pro Pro Val Ser Gly Xaa Leu Gly Ala Gly Leu Gly Xaa Asn Ala 
        515                 520                 525             


Ser Leu Ala Gln Met Val Ser Gly Leu Val Gly Gln Leu Leu Met Gln 
    530                 535                 540                 


Pro Val Leu Val Ala Gln Gly Xaa Pro Gly Ser Pro Gly Gly Leu Gly 
545                 550                 555                 560 


Leu Glu Ser Leu Ser Pro Glu Phe Phe Xaa Ser Val Val Gln Gly Val 
                565                 570                 575     


Leu Ser Ser Leu Leu Gly Ser Leu Gly Ala Arg Ala Gly Ser Ser Glu 
            580                 585                 590         


Ser Ile Ala Ala Phe Ile Gln Arg Leu Ser Gly Ser Ser Asn Ile Phe 
        595                 600                 605             


Glu Pro Gly Ala Asp Gly Ala Leu Gly Phe Phe Gly Ala Leu Leu Ser 
    610                 615                 620                 


Leu Leu Cys Gln Asn Phe Ser Met Val Asp Val Val Met Leu Leu His 
625                 630                 635                 640 


Gly His Phe Gln Pro Leu Gln Arg Leu Gln Pro Gln Leu Arg Ser Phe 
                645                 650                 655     


Phe His Gln His Tyr Leu Gly Gly Gln Glu Pro Xaa Pro Ser Asn Ile 
            660                 665                 670         


Arg Met Ala Xaa His Xaa Leu Ile Xaa Gly Leu Glu Glu Tyr Val Arg 
        675                 680                 685             


Glu Ser Phe Ser Leu Val Gln Val Gln Pro Gly Val Asp Ile Ile Arg 
    690                 695                 700                 


Xaa Asn Leu Glu Phe Leu Gln Glu Gln Phe Asn Ser Ile Ala Ala His 
705                 710                 715                 720 


Val Leu His Cys Xaa Asp Ser Gly Phe Gly Ala Arg Leu Leu Glu Leu 
                725                 730                 735     


Cys Asn Gln Gly Leu Phe Glu Cys Leu Ala Leu Asn Leu His Cys Leu 
            740                 745                 750         


Gly Gly Gln Gln Met Glu Leu Ala Ala Val Ile Asn Gly Arg Ile Arg 
        755                 760                 765             


Arg Met Ser Arg Gly Val Asn Pro Ser Leu Val Ser Trp Leu Xaa Xaa 
    770                 775                 780                 


Met Met Gly Leu Arg Leu Gln Val Val Leu Glu His Met Pro Val Gly 
785                 790                 795                 800 


Pro Asp Ala Ile Leu Arg Tyr Val Arg Arg Val Gly Asp Pro Pro Gln 
                805                 810                 815     


Pro Leu Pro Glu Glu Pro Met Glu Val Gln Gly Ala Glu Arg Ala Ser 
            820                 825                 830         


Pro Glu Pro Gln Glu Trp Val Pro Ile Ile Gln Gln Asp Ile Gln Ser 
        835                 840                 845             


Gln Arg Lys Val Lys Pro Gln Pro Pro Leu Ser Asp Ala Tyr Leu Ser 
    850                 855                 860                 


Gly Met Pro Ala Lys Arg Arg Lys Leu Arg Ser Asp Ile Gln Lys Arg 
865                 870                 875                 880 


Leu Gln Glu Asp Pro Asn Tyr Ser Pro Gln Arg Phe Pro Asn Ala Gln 
                885                 890                 895     


Arg Ala Phe Ala Asp Asp Pro 
            900             


<210> 3846
<211> 1077
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<400> 3846
Met Glu Pro Asn Asp Ser Xaa Ser Xaa Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Xaa Leu Asp Ser Gln Xaa Arg Xaa Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Xaa His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Xaa Gly Ser Ala Ser Ala Xaa His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Xaa Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Xaa Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
145                 150                 155                 160 


Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                165                 170                 175     


Gln Xaa Leu Leu Ser Arg Met Glu Cys Arg Gly Gly Pro Gln Pro Gln 
            180                 185                 190         


His Ser Gln Pro Pro Pro Gln Pro Pro Ala Val Xaa Pro Glu Pro Val 
        195                 200                 205             


Ala Leu Ser Ser Gln Xaa Ser Glu Pro Val Glu Ser Glu Ala Pro Pro 
    210                 215                 220                 


Arg Glu Pro Met Glu Ala Glu Glu Val Glu Glu Arg Ala Pro Ala Gln 
225                 230                 235                 240 


Asn Pro Glu Leu Xaa Pro Gly Pro Ala Pro Ala Gly Pro Xaa Pro Ala 
                245                 250                 255     


Pro Glu Xaa Asn Ala Pro Asn His Pro Ser Pro Ala Glu Tyr Val Glu 
            260                 265                 270         


Val Leu Gln Glu Leu Gln Arg Leu Glu Ser Arg Leu Gln Pro Phe Leu 
        275                 280                 285             


Gln Arg Tyr Tyr Glu Val Leu Gly Ala Ala Ala Xaa Xaa Asp Tyr Asn 
    290                 295                 300                 


Asn Asn His Glu Gly Arg Glu Glu Asp Gln Arg Leu Ile Asn Leu Val 
305                 310                 315                 320 


Gly Glu Ser Leu Arg Leu Leu Gly Asn Xaa Phe Val Ala Leu Ser Asp 
                325                 330                 335     


Leu Arg Cys Asn Leu Ala Cys Xaa Pro Pro Arg His Leu His Val Val 
            340                 345                 350         


Arg Pro Met Ser His Tyr Xaa Xaa Pro Met Val Leu Gln Gln Ala Ala 
        355                 360                 365             


Ile Pro Ile Gln Ile Asn Val Gly Xaa Xaa Val Xaa Met Xaa Gly Asn 
    370                 375                 380                 


Gly Xaa Arg Pro Pro Pro Xaa Pro Asn Ala Glu Ala Pro Pro Pro Gly 
385                 390                 395                 400 


Pro Gly Gln Ala Ser Ser Val Ala Pro Ser Ser Xaa Asn Val Glu Ser 
                405                 410                 415     


Ser Ala Glu Gly Ala Pro Pro Pro Gly Pro Ala Pro Pro Pro Ala Xaa 
            420                 425                 430         


Ser His Pro Arg Val Ile Arg Ile Ser His Gln Ser Val Glu Pro Val 
        435                 440                 445             


Val Met Met His Met Asn Ile Gln Asp Ser Gly Xaa Gln Pro Gly Gly 
    450                 455                 460                 


Val Pro Ser Ala Pro Xaa Gly Pro Leu Gly Pro Pro Gly His Gly Gln 
465                 470                 475                 480 


Xaa Leu Gly Gln Gln Val Pro Gly Phe Pro Xaa Ala Pro Xaa Arg Val 
                485                 490                 495     


Val Ile Ala Arg Pro Xaa Pro Pro Gln Ala Arg Pro Ser His Pro Gly 
            500                 505                 510         


Gly Pro Pro Val Ser Gly Xaa Leu Gln Gly Ala Gly Leu Gly Xaa Asn 
        515                 520                 525             


Ala Ser Leu Ala Gln Met Val Ser Gly Leu Val Gly Gln Leu Leu Met 
    530                 535                 540                 


Gln Pro Val Leu Val Ala Gln Gly Xaa Pro Gly Met Ala Pro Pro Pro 
545                 550                 555                 560 


Ala Pro Ala Xaa Ala Ser Ala Ser Ala Gly Xaa Xaa Asn Xaa Ala Xaa 
                565                 570                 575     


Xaa Ala Gly Pro Ala Pro Gly Gly Pro Ala Gln Pro Pro Pro Xaa Pro 
            580                 585                 590         


Gln Pro Ser Met Ala Asp Leu Gln Phe Ser Gln Leu Leu Gly Asn Leu 
        595                 600                 605             


Leu Gly Pro Ala Gly Pro Gly Ala Gly Gly Ser Gly Val Ala Ser Pro 
    610                 615                 620                 


Xaa Ile Xaa Val Ala Met Pro Gly Val Pro Ala Phe Leu Gln Gly Met 
625                 630                 635                 640 


Xaa Asp Phe Leu Gln Ala Xaa Gln Xaa Ala Pro Pro Pro Pro Pro Pro 
                645                 650                 655     


Pro Pro Pro Pro Pro Pro Ala Pro Glu Gln Gln Xaa Met Pro Pro Pro 
            660                 665                 670         


Gly Ser Pro Ser Gly Gly Ala Gly Ser Pro Gly Gly Leu Gly Leu Glu 
        675                 680                 685             


Ser Leu Ser Pro Glu Phe Phe Xaa Ser Val Val Gln Gly Val Leu Ser 
    690                 695                 700                 


Ser Leu Leu Gly Ser Leu Gly Ala Arg Ala Gly Ser Ser Glu Ser Ile 
705                 710                 715                 720 


Ala Ala Phe Ile Gln Arg Leu Ser Gly Ser Ser Asn Ile Phe Glu Pro 
                725                 730                 735     


Gly Ala Asp Gly Ala Leu Gly Phe Phe Gly Ala Leu Leu Ser Leu Leu 
            740                 745                 750         


Cys Gln Asn Phe Ser Met Val Asp Val Val Met Leu Leu His Gly His 
        755                 760                 765             


Phe Gln Pro Leu Gln Arg Leu Gln Pro Gln Leu Arg Ser Phe Phe His 
    770                 775                 780                 


Gln His Tyr Leu Gly Gly Gln Glu Pro Xaa Pro Ser Asn Ile Arg Met 
785                 790                 795                 800 


Ala Xaa His Xaa Leu Ile Xaa Gly Leu Glu Glu Tyr Val Arg Glu Ser 
                805                 810                 815     


Phe Ser Leu Val Gln Val Gln Pro Gly Val Asp Ile Ile Arg Xaa Asn 
            820                 825                 830         


Leu Glu Phe Leu Gln Glu Gln Phe Asn Ser Ile Ala Ala His Val Leu 
        835                 840                 845             


His Cys Xaa Asp Ser Gly Phe Gly Ala Arg Leu Leu Glu Leu Cys Asn 
    850                 855                 860                 


Gln Gly Leu Phe Glu Cys Leu Ala Leu Asn Leu His Cys Leu Gly Gly 
865                 870                 875                 880 


Gln Gln Met Glu Leu Ala Ala Val Ile Asn Gly Arg Ile Arg Arg Met 
                885                 890                 895     


Ser Arg Gly Val Asn Pro Ser Leu Val Ser Trp Leu Xaa Xaa Met Met 
            900                 905                 910         


Gly Leu Arg Leu Gln Val Val Leu Glu His Met Pro Val Gly Pro Asp 
        915                 920                 925             


Ala Ile Leu Arg Tyr Val Arg Arg Val Gly Asp Pro Pro Gln Pro Leu 
    930                 935                 940                 


Pro Glu Glu Pro Met Glu Val Gln Gly Ala Glu Arg Ala Ser Pro Glu 
945                 950                 955                 960 


Pro Gln Arg Glu Asn Ala Ser Pro Ala Pro Gly Xaa Xaa Ala Glu Glu 
                965                 970                 975     


Ala Met Ser Arg Gly Pro Pro Pro Ala Pro Glu Gly Gly Ser Arg Asp 
            980                 985                 990         


Glu Gln Asp Gly Ala Ser Ala Glu  Xaa Glu Pro Trp Ala  Ala Ala Val 
        995                 1000                 1005             


Pro Pro  Glu Trp Val Pro Ile  Ile Gln Gln Asp Ile  Gln Ser Gln 
    1010                 1015                 1020             


Arg Lys  Val Lys Pro Gln Pro  Pro Leu Ser Asp Ala  Tyr Leu Ser 
    1025                 1030                 1035             


Gly Met  Pro Ala Lys Arg Arg  Lys Leu Arg Ser Asp  Ile Gln Lys 
    1040                 1045                 1050             


Arg Leu  Gln Glu Asp Pro Asn  Tyr Ser Pro Gln Arg  Phe Pro Asn 
    1055                 1060                 1065             


Ala Gln  Arg Ala Phe Ala Asp  Asp Pro 
    1070                 1075         


<210> 3847
<211> 1077
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<400> 3847
Met Glu Pro Asn Asp Ser Xaa Ser Xaa Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Xaa Leu Asp Ser Gln Xaa Arg Xaa Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Xaa His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Xaa Gly Ser Ala Ser Ala Xaa His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Xaa Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Xaa Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
145                 150                 155                 160 


Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                165                 170                 175     


Gln Xaa Leu Leu Ser Arg Met Glu Cys Arg Gly Gly Pro Gln Pro Gln 
            180                 185                 190         


His Ser Gln Pro Pro Pro Gln Pro Pro Ala Val Xaa Pro Glu Pro Val 
        195                 200                 205             


Ala Leu Ser Ser Gln Xaa Ser Glu Pro Val Glu Ser Glu Ala Pro Pro 
    210                 215                 220                 


Arg Glu Pro Met Glu Ala Glu Glu Val Glu Glu Arg Ala Pro Ala Gln 
225                 230                 235                 240 


Asn Pro Glu Leu Xaa Pro Gly Pro Ala Pro Ala Gly Pro Xaa Pro Ala 
                245                 250                 255     


Pro Glu Xaa Asn Ala Pro Asn His Pro Ser Pro Ala Glu Tyr Val Glu 
            260                 265                 270         


Val Leu Gln Glu Leu Gln Arg Leu Glu Ser Arg Leu Gln Pro Phe Leu 
        275                 280                 285             


Gln Arg Tyr Tyr Glu Val Leu Gly Ala Ala Ala Xaa Xaa Asp Tyr Asn 
    290                 295                 300                 


Asn Asn His Glu Gly Arg Glu Glu Asp Gln Arg Leu Ile Asn Leu Val 
305                 310                 315                 320 


Gly Glu Ser Leu Arg Leu Leu Gly Asn Xaa Phe Val Ala Leu Ser Asp 
                325                 330                 335     


Leu Arg Cys Asn Leu Ala Cys Xaa Pro Pro Arg His Leu His Val Val 
            340                 345                 350         


Arg Pro Met Ser His Tyr Xaa Xaa Pro Met Val Leu Gln Gln Ala Ala 
        355                 360                 365             


Ile Pro Ile Gln Ile Asn Val Gly Xaa Xaa Val Xaa Met Xaa Gly Asn 
    370                 375                 380                 


Gly Xaa Arg Pro Pro Pro Xaa Pro Asn Ala Glu Ala Pro Pro Pro Gly 
385                 390                 395                 400 


Pro Gly Gln Ala Ser Ser Val Ala Pro Ser Ser Xaa Asn Val Glu Ser 
                405                 410                 415     


Ser Ala Glu Gly Ala Pro Pro Pro Gly Pro Ala Pro Pro Pro Ala Xaa 
            420                 425                 430         


Ser His Pro Arg Val Ile Arg Ile Ser His Gln Ser Val Glu Pro Val 
        435                 440                 445             


Val Met Met His Met Asn Ile Gln Asp Ser Gly Xaa Gln Pro Gly Gly 
    450                 455                 460                 


Val Pro Ser Ala Pro Xaa Gly Pro Leu Gly Pro Pro Gly His Gly Gln 
465                 470                 475                 480 


Xaa Leu Gly Gln Gln Val Pro Gly Phe Pro Xaa Ala Pro Xaa Arg Val 
                485                 490                 495     


Val Ile Ala Arg Pro Xaa Pro Pro Gln Ala Arg Pro Ser His Pro Gly 
            500                 505                 510         


Gly Pro Pro Val Ser Gly Xaa Leu Gln Gly Ala Gly Leu Gly Xaa Asn 
        515                 520                 525             


Ala Ser Leu Ala Gln Met Val Ser Gly Leu Val Gly Gln Leu Leu Met 
    530                 535                 540                 


Gln Pro Val Leu Val Ala Gln Gly Xaa Pro Gly Met Ala Pro Pro Pro 
545                 550                 555                 560 


Ala Pro Ala Xaa Ala Ser Ala Ser Ala Gly Xaa Xaa Asn Xaa Ala Xaa 
                565                 570                 575     


Xaa Ala Gly Pro Ala Pro Gly Gly Pro Ala Gln Pro Pro Pro Xaa Pro 
            580                 585                 590         


Gln Pro Ser Met Ala Asp Leu Gln Phe Ser Gln Leu Leu Gly Asn Leu 
        595                 600                 605             


Leu Gly Pro Ala Gly Pro Gly Ala Gly Gly Pro Gly Val Ala Ser Pro 
    610                 615                 620                 


Xaa Ile Xaa Val Ala Met Pro Gly Val Pro Ala Phe Leu Gln Gly Met 
625                 630                 635                 640 


Xaa Asp Phe Leu Gln Ala Xaa Gln Xaa Ala Pro Pro Pro Pro Pro Pro 
                645                 650                 655     


Pro Pro Pro Pro Pro Pro Ala Pro Glu Gln Gln Xaa Met Pro Pro Pro 
            660                 665                 670         


Gly Ser Pro Ser Gly Gly Ala Gly Ser Pro Gly Gly Leu Gly Leu Glu 
        675                 680                 685             


Ser Leu Ser Pro Glu Phe Phe Xaa Ser Val Val Gln Gly Val Leu Ser 
    690                 695                 700                 


Ser Leu Leu Gly Ser Leu Gly Ala Arg Ala Gly Ser Ser Glu Ser Ile 
705                 710                 715                 720 


Ala Ala Phe Ile Gln Arg Leu Ser Gly Ser Ser Asn Ile Phe Glu Pro 
                725                 730                 735     


Gly Ala Asp Gly Ala Leu Gly Phe Phe Gly Ala Leu Leu Ser Leu Leu 
            740                 745                 750         


Cys Gln Asn Phe Ser Met Val Asp Val Val Met Leu Leu His Gly His 
        755                 760                 765             


Phe Gln Pro Leu Gln Arg Leu Gln Pro Gln Leu Arg Ser Phe Phe His 
    770                 775                 780                 


Gln His Tyr Leu Gly Gly Gln Glu Pro Xaa Pro Ser Asn Ile Arg Met 
785                 790                 795                 800 


Ala Xaa His Xaa Leu Ile Xaa Gly Leu Glu Glu Tyr Val Arg Glu Ser 
                805                 810                 815     


Phe Ser Leu Val Gln Val Gln Pro Gly Val Asp Ile Ile Arg Xaa Asn 
            820                 825                 830         


Leu Glu Phe Leu Gln Glu Gln Phe Asn Ser Ile Ala Ala His Val Leu 
        835                 840                 845             


His Cys Xaa Asp Ser Gly Phe Gly Ala Arg Leu Leu Glu Leu Cys Asn 
    850                 855                 860                 


Gln Gly Leu Phe Glu Cys Leu Ala Leu Asn Leu His Cys Leu Gly Gly 
865                 870                 875                 880 


Gln Gln Met Glu Leu Ala Ala Val Ile Asn Gly Arg Ile Arg Arg Met 
                885                 890                 895     


Ser Arg Gly Val Asn Pro Ser Leu Val Ser Trp Leu Xaa Xaa Met Met 
            900                 905                 910         


Gly Leu Arg Leu Gln Val Val Leu Glu His Met Pro Val Gly Pro Asp 
        915                 920                 925             


Ala Ile Leu Arg Tyr Val Arg Arg Val Gly Asp Pro Pro Gln Pro Leu 
    930                 935                 940                 


Pro Glu Glu Pro Met Glu Val Gln Gly Ala Glu Arg Ala Ser Pro Glu 
945                 950                 955                 960 


Pro Gln Arg Glu Asn Ala Ser Pro Ala Pro Gly Xaa Xaa Ala Glu Glu 
                965                 970                 975     


Ala Met Ser Arg Gly Pro Pro Pro Ala Pro Glu Gly Gly Ser Arg Asp 
            980                 985                 990         


Glu Gln Asp Gly Ala Ser Ala Glu  Xaa Glu Pro Trp Ala  Ala Ala Val 
        995                 1000                 1005             


Pro Pro  Glu Trp Val Pro Ile  Ile Gln Gln Asp Ile  Gln Ser Gln 
    1010                 1015                 1020             


Arg Lys  Val Lys Pro Gln Pro  Pro Leu Ser Asp Ala  Tyr Leu Ser 
    1025                 1030                 1035             


Gly Met  Pro Ala Lys Arg Arg  Lys Leu Arg Ser Asp  Ile Gln Lys 
    1040                 1045                 1050             


Arg Leu  Gln Glu Asp Pro Asn  Tyr Ser Pro Gln Arg  Phe Pro Asn 
    1055                 1060                 1065             


Ala Gln  Arg Ala Phe Ala Asp  Asp Pro 
    1070                 1075         


<210> 3848
<211> 1126
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<400> 3848
Met Glu Pro Asn Asp Ser Xaa Ser Xaa Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Xaa Leu Asp Ser Gln Xaa Arg Xaa Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Xaa His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Xaa Gly Ser Ala Ser Ala Xaa His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Xaa Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Xaa Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
145                 150                 155                 160 


Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                165                 170                 175     


Gln Xaa Leu Leu Ser Arg Met Glu Cys Arg Gly Gly Pro Gln Pro Gln 
            180                 185                 190         


His Ser Gln Pro Pro Pro Gln Pro Pro Ala Val Xaa Pro Glu Pro Val 
        195                 200                 205             


Ala Leu Ser Ser Gln Xaa Ser Glu Pro Val Glu Ser Glu Ala Pro Pro 
    210                 215                 220                 


Arg Glu Pro Met Glu Ala Glu Glu Val Glu Glu Arg Ala Pro Ala Gln 
225                 230                 235                 240 


Asn Pro Glu Leu Xaa Pro Gly Pro Ala Pro Ala Gly Pro Xaa Pro Ala 
                245                 250                 255     


Pro Glu Xaa Asn Ala Pro Asn His Pro Ser Pro Ala Glu Tyr Val Glu 
            260                 265                 270         


Val Leu Gln Glu Leu Gln Arg Leu Glu Ser Arg Leu Gln Pro Phe Leu 
        275                 280                 285             


Gln Arg Tyr Tyr Glu Val Leu Gly Ala Ala Ala Xaa Xaa Asp Tyr Asn 
    290                 295                 300                 


Asn Asn His Glu Gly Arg Glu Glu Asp Gln Arg Leu Ile Asn Leu Val 
305                 310                 315                 320 


Gly Glu Ser Leu Arg Leu Leu Gly Asn Xaa Phe Val Ala Leu Ser Asp 
                325                 330                 335     


Leu Arg Cys Asn Leu Ala Cys Xaa Pro Pro Arg His Leu His Val Val 
            340                 345                 350         


Arg Pro Met Ser His Tyr Xaa Xaa Pro Met Val Leu Gln Gln Ala Ala 
        355                 360                 365             


Ile Pro Ile Gln Ile Asn Val Gly Xaa Xaa Val Xaa Met Xaa Gly Asn 
    370                 375                 380                 


Gly Xaa Arg Pro Pro Pro Xaa Pro Asn Ala Glu Ala Pro Pro Pro Gly 
385                 390                 395                 400 


Pro Gly Gln Ala Ser Ser Val Ala Pro Ser Ser Xaa Asn Val Glu Ser 
                405                 410                 415     


Ser Ala Glu Gly Ala Pro Pro Pro Gly Pro Ala Pro Pro Pro Ala Xaa 
            420                 425                 430         


Ser His Pro Arg Val Ile Arg Ile Ser His Gln Ser Val Glu Pro Val 
        435                 440                 445             


Val Met Met His Met Asn Ile Gln Asp Ser Gly Xaa Gln Pro Gly Gly 
    450                 455                 460                 


Val Pro Ser Ala Pro Xaa Gly Pro Leu Gly Pro Pro Gly His Gly Gln 
465                 470                 475                 480 


Xaa Leu Gly Gln Gln Val Pro Gly Phe Pro Xaa Ala Pro Xaa Arg Val 
                485                 490                 495     


Val Ile Ala Arg Pro Xaa Pro Pro Gln Ala Arg Pro Ser His Pro Gly 
            500                 505                 510         


Gly Pro Pro Val Ser Gly Xaa Leu Gln Gly Ala Gly Leu Gly Xaa Asn 
        515                 520                 525             


Ala Ser Leu Ala Gln Met Val Ser Gly Leu Val Gly Gln Leu Leu Met 
    530                 535                 540                 


Gln Pro Val Leu Val Ala Gln Gly Xaa Pro Gly Met Ala Pro Pro Pro 
545                 550                 555                 560 


Ala Pro Ala Xaa Ala Ser Ala Ser Ala Gly Xaa Xaa Asn Xaa Ala Xaa 
                565                 570                 575     


Xaa Ala Gly Pro Ala Pro Gly Gly Pro Ala Gln Pro Pro Pro Xaa Pro 
            580                 585                 590         


Gln Pro Ser Met Ala Asp Leu Gln Phe Ser Gln Leu Leu Gly Asn Leu 
        595                 600                 605             


Leu Gly Pro Ala Gly Pro Gly Ala Gly Gly Ser Gly Val Ala Ser Pro 
    610                 615                 620                 


Xaa Ile Xaa Val Ala Met Pro Gly Val Pro Ala Phe Leu Gln Gly Met 
625                 630                 635                 640 


Xaa Asp Phe Leu Gln Ala Xaa Gln Xaa Ala Pro Pro Pro Pro Pro Pro 
                645                 650                 655     


Pro Pro Pro Pro Pro Pro Ala Pro Glu Gln Gln Xaa Met Pro Pro Pro 
            660                 665                 670         


Gly Ser Pro Ser Gly Gly Ala Gly Ser Pro Gly Gly Leu Gly Leu Glu 
        675                 680                 685             


Ser Leu Ser Pro Glu Phe Phe Xaa Ser Val Val Gln Gly Val Leu Ser 
    690                 695                 700                 


Ser Leu Leu Gly Ser Leu Gly Ala Arg Ala Gly Ser Ser Glu Ser Ile 
705                 710                 715                 720 


Ala Ala Phe Ile Gln Arg Leu Ser Gly Ser Ser Asn Ile Phe Glu Pro 
                725                 730                 735     


Gly Ala Asp Gly Ala Leu Gly Phe Phe Gly Ala Leu Leu Ser Leu Leu 
            740                 745                 750         


Cys Gln Asn Phe Ser Met Val Asp Val Val Met Leu Leu His Gly His 
        755                 760                 765             


Phe Gln Pro Leu Gln Arg Leu Gln Pro Gln Leu Arg Ser Phe Phe His 
    770                 775                 780                 


Gln His Tyr Leu Gly Gly Gln Glu Pro Xaa Pro Ser Asn Ile Arg Met 
785                 790                 795                 800 


Ala Xaa His Xaa Leu Ile Xaa Gly Leu Glu Glu Tyr Val Arg Glu Ser 
                805                 810                 815     


Phe Ser Leu Val Gln Val Gln Pro Gly Val Asp Ile Ile Arg Xaa Asn 
            820                 825                 830         


Leu Glu Phe Leu Gln Glu Gln Phe Asn Ser Ile Ala Ala His Val Leu 
        835                 840                 845             


His Cys Xaa Asp Ser Gly Phe Gly Ala Arg Leu Leu Glu Leu Cys Asn 
    850                 855                 860                 


Gln Gly Leu Phe Glu Cys Leu Ala Leu Asn Leu His Cys Leu Gly Gly 
865                 870                 875                 880 


Gln Gln Met Glu Leu Ala Ala Val Ile Asn Gly Arg Ile Arg Arg Met 
                885                 890                 895     


Ser Arg Gly Val Asn Pro Ser Leu Val Ser Trp Leu Xaa Xaa Met Met 
            900                 905                 910         


Gly Leu Arg Leu Gln Val Val Leu Glu His Met Pro Val Gly Pro Asp 
        915                 920                 925             


Ala Ile Leu Arg Tyr Val Arg Arg Val Gly Asp Pro Pro Gln Pro Leu 
    930                 935                 940                 


Pro Glu Glu Pro Met Glu Val Gln Gly Ala Glu Arg Ala Ser Pro Glu 
945                 950                 955                 960 


Pro Gln Arg Glu Asn Ala Ser Pro Ala Pro Gly Xaa Xaa Ala Glu Glu 
                965                 970                 975     


Ala Met Ser Arg Gly Pro Pro Pro Ala Pro Glu Gly Gly Ser Arg Asp 
            980                 985                 990         


Glu Gln Asp Gly Ala Ser Ala Glu  Xaa Glu Pro Trp Ala  Ala Ala Val 
        995                 1000                 1005             


Pro Pro  Glu Trp Val Pro Ile  Ile Gln Gln Asp Ile  Gln Ser Gln 
    1010                 1015                 1020             


Arg Lys  Val Lys Pro Gln Pro  Pro Leu Ser Asp Ala  Tyr Leu Ser 
    1025                 1030                 1035             


Gly Met  Pro Ala Lys Arg Arg  Lys Xaa Met Gln Gly  Glu Gly Pro 
    1040                 1045                 1050             


Gln Leu  Leu Leu Ser Glu Ala  Val Ser Arg Ala Ala  Lys Ala Ala 
    1055                 1060                 1065             


Gly Ala  Arg Pro Leu Xaa Ser  Pro Glu Ser Leu Ser  Arg Asp Leu 
    1070                 1075                 1080             


Glu Ala  Pro Glu Val Gln Glu  Ser Tyr Arg Gln Gln  Leu Arg Ser 
    1085                 1090                 1095             


Asp Ile  Gln Lys Arg Leu Gln  Glu Asp Pro Asn Tyr  Ser Pro Gln 
    1100                 1105                 1110             


Arg Phe  Pro Asn Ala Gln Arg  Ala Phe Ala Asp Asp  Pro 
    1115                 1120                 1125     


<210> 3849
<211> 1126
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<400> 3849
Met Glu Pro Asn Asp Ser Xaa Ser Xaa Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Xaa Leu Asp Ser Gln Xaa Arg Xaa Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Xaa His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Xaa Gly Ser Ala Ser Ala Xaa His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Xaa Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Xaa Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
145                 150                 155                 160 


Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                165                 170                 175     


Gln Xaa Leu Leu Ser Arg Met Glu Cys Arg Gly Gly Pro Gln Pro Gln 
            180                 185                 190         


His Ser Gln Pro Pro Pro Gln Pro Pro Ala Val Xaa Pro Glu Pro Val 
        195                 200                 205             


Ala Leu Ser Ser Gln Xaa Ser Glu Pro Val Glu Ser Glu Ala Pro Pro 
    210                 215                 220                 


Arg Glu Pro Met Glu Ala Glu Glu Val Glu Glu Arg Ala Pro Ala Gln 
225                 230                 235                 240 


Asn Pro Glu Leu Xaa Pro Gly Pro Ala Pro Ala Gly Pro Xaa Pro Ala 
                245                 250                 255     


Pro Glu Xaa Asn Ala Pro Asn His Pro Ser Pro Ala Glu Tyr Val Glu 
            260                 265                 270         


Val Leu Gln Glu Leu Gln Arg Leu Glu Ser Arg Leu Gln Pro Phe Leu 
        275                 280                 285             


Gln Arg Tyr Tyr Glu Val Leu Gly Ala Ala Ala Xaa Xaa Asp Tyr Asn 
    290                 295                 300                 


Asn Asn His Glu Gly Arg Glu Glu Asp Gln Arg Leu Ile Asn Leu Val 
305                 310                 315                 320 


Gly Glu Ser Leu Arg Leu Leu Gly Asn Xaa Phe Val Ala Leu Ser Asp 
                325                 330                 335     


Leu Arg Cys Asn Leu Ala Cys Xaa Pro Pro Arg His Leu His Val Val 
            340                 345                 350         


Arg Pro Met Ser His Tyr Xaa Xaa Pro Met Val Leu Gln Gln Ala Ala 
        355                 360                 365             


Ile Pro Ile Gln Ile Asn Val Gly Xaa Xaa Val Xaa Met Xaa Gly Asn 
    370                 375                 380                 


Gly Xaa Arg Pro Pro Pro Xaa Pro Asn Ala Glu Ala Pro Pro Pro Gly 
385                 390                 395                 400 


Pro Gly Gln Ala Ser Ser Val Ala Pro Ser Ser Xaa Asn Val Glu Ser 
                405                 410                 415     


Ser Ala Glu Gly Ala Pro Pro Pro Gly Pro Ala Pro Pro Pro Ala Xaa 
            420                 425                 430         


Ser His Pro Arg Val Ile Arg Ile Ser His Gln Ser Val Glu Pro Val 
        435                 440                 445             


Val Met Met His Met Asn Ile Gln Asp Ser Gly Xaa Gln Pro Gly Gly 
    450                 455                 460                 


Val Pro Ser Ala Pro Xaa Gly Pro Leu Gly Pro Pro Gly His Gly Gln 
465                 470                 475                 480 


Xaa Leu Gly Gln Gln Val Pro Gly Phe Pro Xaa Ala Pro Xaa Arg Val 
                485                 490                 495     


Val Ile Ala Arg Pro Xaa Pro Pro Gln Ala Arg Pro Ser His Pro Gly 
            500                 505                 510         


Gly Pro Pro Val Ser Gly Xaa Leu Gln Gly Ala Gly Leu Gly Xaa Asn 
        515                 520                 525             


Ala Ser Leu Ala Gln Met Val Ser Gly Leu Val Gly Gln Leu Leu Met 
    530                 535                 540                 


Gln Pro Val Leu Val Ala Gln Gly Xaa Pro Gly Met Ala Pro Pro Pro 
545                 550                 555                 560 


Ala Pro Ala Xaa Ala Ser Ala Ser Ala Gly Xaa Xaa Asn Xaa Ala Xaa 
                565                 570                 575     


Xaa Ala Gly Pro Ala Pro Gly Gly Pro Ala Gln Pro Pro Pro Xaa Pro 
            580                 585                 590         


Gln Pro Ser Met Ala Asp Leu Gln Phe Ser Gln Leu Leu Gly Asn Leu 
        595                 600                 605             


Leu Gly Pro Ala Gly Pro Gly Ala Gly Gly Pro Gly Val Ala Ser Pro 
    610                 615                 620                 


Xaa Ile Xaa Val Ala Met Pro Gly Val Pro Ala Phe Leu Gln Gly Met 
625                 630                 635                 640 


Xaa Asp Phe Leu Gln Ala Xaa Gln Xaa Ala Pro Pro Pro Pro Pro Pro 
                645                 650                 655     


Pro Pro Pro Pro Pro Pro Ala Pro Glu Gln Gln Xaa Met Pro Pro Pro 
            660                 665                 670         


Gly Ser Pro Ser Gly Gly Ala Gly Ser Pro Gly Gly Leu Gly Leu Glu 
        675                 680                 685             


Ser Leu Ser Pro Glu Phe Phe Xaa Ser Val Val Gln Gly Val Leu Ser 
    690                 695                 700                 


Ser Leu Leu Gly Ser Leu Gly Ala Arg Ala Gly Ser Ser Glu Ser Ile 
705                 710                 715                 720 


Ala Ala Phe Ile Gln Arg Leu Ser Gly Ser Ser Asn Ile Phe Glu Pro 
                725                 730                 735     


Gly Ala Asp Gly Ala Leu Gly Phe Phe Gly Ala Leu Leu Ser Leu Leu 
            740                 745                 750         


Cys Gln Asn Phe Ser Met Val Asp Val Val Met Leu Leu His Gly His 
        755                 760                 765             


Phe Gln Pro Leu Gln Arg Leu Gln Pro Gln Leu Arg Ser Phe Phe His 
    770                 775                 780                 


Gln His Tyr Leu Gly Gly Gln Glu Pro Xaa Pro Ser Asn Ile Arg Met 
785                 790                 795                 800 


Ala Xaa His Xaa Leu Ile Xaa Gly Leu Glu Glu Tyr Val Arg Glu Ser 
                805                 810                 815     


Phe Ser Leu Val Gln Val Gln Pro Gly Val Asp Ile Ile Arg Xaa Asn 
            820                 825                 830         


Leu Glu Phe Leu Gln Glu Gln Phe Asn Ser Ile Ala Ala His Val Leu 
        835                 840                 845             


His Cys Xaa Asp Ser Gly Phe Gly Ala Arg Leu Leu Glu Leu Cys Asn 
    850                 855                 860                 


Gln Gly Leu Phe Glu Cys Leu Ala Leu Asn Leu His Cys Leu Gly Gly 
865                 870                 875                 880 


Gln Gln Met Glu Leu Ala Ala Val Ile Asn Gly Arg Ile Arg Arg Met 
                885                 890                 895     


Ser Arg Gly Val Asn Pro Ser Leu Val Ser Trp Leu Xaa Xaa Met Met 
            900                 905                 910         


Gly Leu Arg Leu Gln Val Val Leu Glu His Met Pro Val Gly Pro Asp 
        915                 920                 925             


Ala Ile Leu Arg Tyr Val Arg Arg Val Gly Asp Pro Pro Gln Pro Leu 
    930                 935                 940                 


Pro Glu Glu Pro Met Glu Val Gln Gly Ala Glu Arg Ala Ser Pro Glu 
945                 950                 955                 960 


Pro Gln Arg Glu Asn Ala Ser Pro Ala Pro Gly Xaa Xaa Ala Glu Glu 
                965                 970                 975     


Ala Met Ser Arg Gly Pro Pro Pro Ala Pro Glu Gly Gly Ser Arg Asp 
            980                 985                 990         


Glu Gln Asp Gly Ala Ser Ala Glu  Xaa Glu Pro Trp Ala  Ala Ala Val 
        995                 1000                 1005             


Pro Pro  Glu Trp Val Pro Ile  Ile Gln Gln Asp Ile  Gln Ser Gln 
    1010                 1015                 1020             


Arg Lys  Val Lys Pro Gln Pro  Pro Leu Ser Asp Ala  Tyr Leu Ser 
    1025                 1030                 1035             


Gly Met  Pro Ala Lys Arg Arg  Lys Xaa Met Gln Gly  Glu Gly Pro 
    1040                 1045                 1050             


Gln Leu  Leu Leu Ser Glu Ala  Val Ser Arg Ala Ala  Lys Ala Ala 
    1055                 1060                 1065             


Gly Ala  Arg Pro Leu Xaa Ser  Pro Glu Ser Leu Ser  Arg Asp Leu 
    1070                 1075                 1080             


Glu Ala  Pro Glu Val Gln Glu  Ser Tyr Arg Gln Gln  Leu Arg Ser 
    1085                 1090                 1095             


Asp Ile  Gln Lys Arg Leu Gln  Glu Asp Pro Asn Tyr  Ser Pro Gln 
    1100                 1105                 1110             


Arg Phe  Pro Asn Ala Gln Arg  Ala Phe Ala Asp Asp  Pro 
    1115                 1120                 1125     


<210> 3850
<211> 233
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<400> 3850
Met Glu Pro Asn Asp Ser Xaa Ser Xaa Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Xaa Leu Asp Ser Gln Xaa Arg Xaa Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Xaa His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Xaa Gly Ser Ala Ser Ala Xaa His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Xaa Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Xaa Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
145                 150                 155                 160 


Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                165                 170                 175     


Gln Xaa Leu Leu Ser Arg Met Glu Xaa Leu Pro Tyr Leu Gln Cys Arg 
            180                 185                 190         


Gly Gly Pro Gln Pro Gln His Ser Gln Pro Pro Pro Gln Pro Pro Ala 
        195                 200                 205             


Val Xaa Pro Glu Pro Val Ala Leu Ser Ser Gln Xaa Ser Glu Pro Val 
    210                 215                 220                 


Glu Ser Glu Ala Pro Pro Arg Glu Pro 
225                 230             


<210> 3851
<211> 1132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1007)..(1007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<400> 3851
Met Glu Pro Asn Asp Ser Xaa Ser Xaa Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Xaa Leu Asp Ser Gln Xaa Arg Xaa Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Xaa His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Xaa Gly Ser Ala Ser Ala Xaa His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Xaa Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Xaa Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
145                 150                 155                 160 


Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                165                 170                 175     


Gln Xaa Leu Leu Ser Arg Met Glu Xaa Leu Pro Tyr Leu Gln Cys Arg 
            180                 185                 190         


Gly Gly Pro Gln Pro Gln His Ser Gln Pro Pro Pro Gln Pro Pro Ala 
        195                 200                 205             


Val Xaa Pro Glu Pro Val Ala Leu Ser Ser Gln Xaa Ser Glu Pro Val 
    210                 215                 220                 


Glu Ser Glu Ala Pro Pro Arg Glu Pro Met Glu Ala Glu Glu Val Glu 
225                 230                 235                 240 


Glu Arg Ala Pro Ala Gln Asn Pro Glu Leu Xaa Pro Gly Pro Ala Pro 
                245                 250                 255     


Ala Gly Pro Xaa Pro Ala Pro Glu Xaa Asn Ala Pro Asn His Pro Ser 
            260                 265                 270         


Pro Ala Glu Tyr Val Glu Val Leu Gln Glu Leu Gln Arg Leu Glu Ser 
        275                 280                 285             


Arg Leu Gln Pro Phe Leu Gln Arg Tyr Tyr Glu Val Leu Gly Ala Ala 
    290                 295                 300                 


Ala Xaa Xaa Asp Tyr Asn Asn Asn His Glu Gly Arg Glu Glu Asp Gln 
305                 310                 315                 320 


Arg Leu Ile Asn Leu Val Gly Glu Ser Leu Arg Leu Leu Gly Asn Xaa 
                325                 330                 335     


Phe Val Ala Leu Ser Asp Leu Arg Cys Asn Leu Ala Cys Xaa Pro Pro 
            340                 345                 350         


Arg His Leu His Val Val Arg Pro Met Ser His Tyr Xaa Xaa Pro Met 
        355                 360                 365             


Val Leu Gln Gln Ala Ala Ile Pro Ile Gln Ile Asn Val Gly Xaa Xaa 
    370                 375                 380                 


Val Xaa Met Xaa Gly Asn Gly Xaa Arg Pro Pro Pro Xaa Pro Asn Ala 
385                 390                 395                 400 


Glu Ala Pro Pro Pro Gly Pro Gly Gln Ala Ser Ser Val Ala Pro Ser 
                405                 410                 415     


Ser Xaa Asn Val Glu Ser Ser Ala Glu Gly Ala Pro Pro Pro Gly Pro 
            420                 425                 430         


Ala Pro Pro Pro Ala Xaa Ser His Pro Arg Val Ile Arg Ile Ser His 
        435                 440                 445             


Gln Ser Val Glu Pro Val Val Met Met His Met Asn Ile Gln Asp Ser 
    450                 455                 460                 


Gly Xaa Gln Pro Gly Gly Val Pro Ser Ala Pro Xaa Gly Pro Leu Gly 
465                 470                 475                 480 


Pro Pro Gly His Gly Gln Xaa Leu Gly Gln Gln Val Pro Gly Phe Pro 
                485                 490                 495     


Xaa Ala Pro Xaa Arg Val Val Ile Ala Arg Pro Xaa Pro Pro Gln Ala 
            500                 505                 510         


Arg Pro Ser His Pro Gly Gly Pro Pro Val Ser Gly Xaa Leu Gln Gly 
        515                 520                 525             


Ala Gly Leu Gly Xaa Asn Ala Ser Leu Ala Gln Met Val Ser Gly Leu 
    530                 535                 540                 


Val Gly Gln Leu Leu Met Gln Pro Val Leu Val Ala Gln Gly Xaa Pro 
545                 550                 555                 560 


Gly Met Ala Pro Pro Pro Ala Pro Ala Xaa Ala Ser Ala Ser Ala Gly 
                565                 570                 575     


Xaa Xaa Asn Xaa Ala Xaa Xaa Ala Gly Pro Ala Pro Gly Gly Pro Ala 
            580                 585                 590         


Gln Pro Pro Pro Xaa Pro Gln Pro Ser Met Ala Asp Leu Gln Phe Ser 
        595                 600                 605             


Gln Leu Leu Gly Asn Leu Leu Gly Pro Ala Gly Pro Gly Ala Gly Gly 
    610                 615                 620                 


Ser Gly Val Ala Ser Pro Xaa Ile Xaa Val Ala Met Pro Gly Val Pro 
625                 630                 635                 640 


Ala Phe Leu Gln Gly Met Xaa Asp Phe Leu Gln Ala Xaa Gln Xaa Ala 
                645                 650                 655     


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro Glu Gln 
            660                 665                 670         


Gln Xaa Met Pro Pro Pro Gly Ser Pro Ser Gly Gly Ala Gly Ser Pro 
        675                 680                 685             


Gly Gly Leu Gly Leu Glu Ser Leu Ser Pro Glu Phe Phe Xaa Ser Val 
    690                 695                 700                 


Val Gln Gly Val Leu Ser Ser Leu Leu Gly Ser Leu Gly Ala Arg Ala 
705                 710                 715                 720 


Gly Ser Ser Glu Ser Ile Ala Ala Phe Ile Gln Arg Leu Ser Gly Ser 
                725                 730                 735     


Ser Asn Ile Phe Glu Pro Gly Ala Asp Gly Ala Leu Gly Phe Phe Gly 
            740                 745                 750         


Ala Leu Leu Ser Leu Leu Cys Gln Asn Phe Ser Met Val Asp Val Val 
        755                 760                 765             


Met Leu Leu His Gly His Phe Gln Pro Leu Gln Arg Leu Gln Pro Gln 
    770                 775                 780                 


Leu Arg Ser Phe Phe His Gln His Tyr Leu Gly Gly Gln Glu Pro Xaa 
785                 790                 795                 800 


Pro Ser Asn Ile Arg Met Ala Xaa His Xaa Leu Ile Xaa Gly Leu Glu 
                805                 810                 815     


Glu Tyr Val Arg Glu Ser Phe Ser Leu Val Gln Val Gln Pro Gly Val 
            820                 825                 830         


Asp Ile Ile Arg Xaa Asn Leu Glu Phe Leu Gln Glu Gln Phe Asn Ser 
        835                 840                 845             


Ile Ala Ala His Val Leu His Cys Xaa Asp Ser Gly Phe Gly Ala Arg 
    850                 855                 860                 


Leu Leu Glu Leu Cys Asn Gln Gly Leu Phe Glu Cys Leu Ala Leu Asn 
865                 870                 875                 880 


Leu His Cys Leu Gly Gly Gln Gln Met Glu Leu Ala Ala Val Ile Asn 
                885                 890                 895     


Gly Arg Ile Arg Arg Met Ser Arg Gly Val Asn Pro Ser Leu Val Ser 
            900                 905                 910         


Trp Leu Xaa Xaa Met Met Gly Leu Arg Leu Gln Val Val Leu Glu His 
        915                 920                 925             


Met Pro Val Gly Pro Asp Ala Ile Leu Arg Tyr Val Arg Arg Val Gly 
    930                 935                 940                 


Asp Pro Pro Gln Pro Leu Pro Glu Glu Pro Met Glu Val Gln Gly Ala 
945                 950                 955                 960 


Glu Arg Ala Ser Pro Glu Pro Gln Arg Glu Asn Ala Ser Pro Ala Pro 
                965                 970                 975     


Gly Xaa Xaa Ala Glu Glu Ala Met Ser Arg Gly Pro Pro Pro Ala Pro 
            980                 985                 990         


Glu Gly Gly Ser Arg Asp Glu Gln  Asp Gly Ala Ser Ala  Glu Xaa Glu 
        995                 1000                 1005             


Pro Trp  Ala Ala Ala Val Pro  Pro Glu Trp Val Pro  Ile Ile Gln 
    1010                 1015                 1020             


Gln Asp  Ile Gln Ser Gln Arg  Lys Val Lys Pro Gln  Pro Pro Leu 
    1025                 1030                 1035             


Ser Asp  Ala Tyr Leu Ser Gly  Met Pro Ala Lys Arg  Arg Lys Xaa 
    1040                 1045                 1050             


Met Gln  Gly Glu Gly Pro Gln  Leu Leu Leu Ser Glu  Ala Val Ser 
    1055                 1060                 1065             


Arg Ala  Ala Lys Ala Ala Gly  Ala Arg Pro Leu Xaa  Ser Pro Glu 
    1070                 1075                 1080             


Ser Leu  Ser Arg Asp Leu Glu  Ala Pro Glu Val Gln  Glu Ser Tyr 
    1085                 1090                 1095             


Arg Gln  Gln Leu Arg Ser Asp  Ile Gln Lys Arg Leu  Gln Glu Asp 
    1100                 1105                 1110             


Pro Asn  Tyr Ser Pro Gln Arg  Phe Pro Asn Ala Gln  Arg Ala Phe 
    1115                 1120                 1125             


Ala Asp  Asp Pro 
    1130         


<210> 3852
<211> 1132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1007)..(1007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<400> 3852
Met Glu Pro Asn Asp Ser Xaa Ser Xaa Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Xaa Leu Asp Ser Gln Xaa Arg Xaa Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Xaa His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Xaa Gly Ser Ala Ser Ala Xaa His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Xaa Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Xaa Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
145                 150                 155                 160 


Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                165                 170                 175     


Gln Xaa Leu Leu Ser Arg Met Glu Xaa Leu Pro Tyr Leu Gln Cys Arg 
            180                 185                 190         


Gly Gly Pro Gln Pro Gln His Ser Gln Pro Pro Pro Gln Pro Pro Ala 
        195                 200                 205             


Val Xaa Pro Glu Pro Val Ala Leu Ser Ser Gln Xaa Ser Glu Pro Val 
    210                 215                 220                 


Glu Ser Glu Ala Pro Pro Arg Glu Pro Met Glu Ala Glu Glu Val Glu 
225                 230                 235                 240 


Glu Arg Ala Pro Ala Gln Asn Pro Glu Leu Xaa Pro Gly Pro Ala Pro 
                245                 250                 255     


Ala Gly Pro Xaa Pro Ala Pro Glu Xaa Asn Ala Pro Asn His Pro Ser 
            260                 265                 270         


Pro Ala Glu Tyr Val Glu Val Leu Gln Glu Leu Gln Arg Leu Glu Ser 
        275                 280                 285             


Arg Leu Gln Pro Phe Leu Gln Arg Tyr Tyr Glu Val Leu Gly Ala Ala 
    290                 295                 300                 


Ala Xaa Xaa Asp Tyr Asn Asn Asn His Glu Gly Arg Glu Glu Asp Gln 
305                 310                 315                 320 


Arg Leu Ile Asn Leu Val Gly Glu Ser Leu Arg Leu Leu Gly Asn Xaa 
                325                 330                 335     


Phe Val Ala Leu Ser Asp Leu Arg Cys Asn Leu Ala Cys Xaa Pro Pro 
            340                 345                 350         


Arg His Leu His Val Val Arg Pro Met Ser His Tyr Xaa Xaa Pro Met 
        355                 360                 365             


Val Leu Gln Gln Ala Ala Ile Pro Ile Gln Ile Asn Val Gly Xaa Xaa 
    370                 375                 380                 


Val Xaa Met Xaa Gly Asn Gly Xaa Arg Pro Pro Pro Xaa Pro Asn Ala 
385                 390                 395                 400 


Glu Ala Pro Pro Pro Gly Pro Gly Gln Ala Ser Ser Val Ala Pro Ser 
                405                 410                 415     


Ser Xaa Asn Val Glu Ser Ser Ala Glu Gly Ala Pro Pro Pro Gly Pro 
            420                 425                 430         


Ala Pro Pro Pro Ala Xaa Ser His Pro Arg Val Ile Arg Ile Ser His 
        435                 440                 445             


Gln Ser Val Glu Pro Val Val Met Met His Met Asn Ile Gln Asp Ser 
    450                 455                 460                 


Gly Xaa Gln Pro Gly Gly Val Pro Ser Ala Pro Xaa Gly Pro Leu Gly 
465                 470                 475                 480 


Pro Pro Gly His Gly Gln Xaa Leu Gly Gln Gln Val Pro Gly Phe Pro 
                485                 490                 495     


Xaa Ala Pro Xaa Arg Val Val Ile Ala Arg Pro Xaa Pro Pro Gln Ala 
            500                 505                 510         


Arg Pro Ser His Pro Gly Gly Pro Pro Val Ser Gly Xaa Leu Gln Gly 
        515                 520                 525             


Ala Gly Leu Gly Xaa Asn Ala Ser Leu Ala Gln Met Val Ser Gly Leu 
    530                 535                 540                 


Val Gly Gln Leu Leu Met Gln Pro Val Leu Val Ala Gln Gly Xaa Pro 
545                 550                 555                 560 


Gly Met Ala Pro Pro Pro Ala Pro Ala Xaa Ala Ser Ala Ser Ala Gly 
                565                 570                 575     


Xaa Xaa Asn Xaa Ala Xaa Xaa Ala Gly Pro Ala Pro Gly Gly Pro Ala 
            580                 585                 590         


Gln Pro Pro Pro Xaa Pro Gln Pro Ser Met Ala Asp Leu Gln Phe Ser 
        595                 600                 605             


Gln Leu Leu Gly Asn Leu Leu Gly Pro Ala Gly Pro Gly Ala Gly Gly 
    610                 615                 620                 


Pro Gly Val Ala Ser Pro Xaa Ile Xaa Val Ala Met Pro Gly Val Pro 
625                 630                 635                 640 


Ala Phe Leu Gln Gly Met Xaa Asp Phe Leu Gln Ala Xaa Gln Xaa Ala 
                645                 650                 655     


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro Glu Gln 
            660                 665                 670         


Gln Xaa Met Pro Pro Pro Gly Ser Pro Ser Gly Gly Ala Gly Ser Pro 
        675                 680                 685             


Gly Gly Leu Gly Leu Glu Ser Leu Ser Pro Glu Phe Phe Xaa Ser Val 
    690                 695                 700                 


Val Gln Gly Val Leu Ser Ser Leu Leu Gly Ser Leu Gly Ala Arg Ala 
705                 710                 715                 720 


Gly Ser Ser Glu Ser Ile Ala Ala Phe Ile Gln Arg Leu Ser Gly Ser 
                725                 730                 735     


Ser Asn Ile Phe Glu Pro Gly Ala Asp Gly Ala Leu Gly Phe Phe Gly 
            740                 745                 750         


Ala Leu Leu Ser Leu Leu Cys Gln Asn Phe Ser Met Val Asp Val Val 
        755                 760                 765             


Met Leu Leu His Gly His Phe Gln Pro Leu Gln Arg Leu Gln Pro Gln 
    770                 775                 780                 


Leu Arg Ser Phe Phe His Gln His Tyr Leu Gly Gly Gln Glu Pro Xaa 
785                 790                 795                 800 


Pro Ser Asn Ile Arg Met Ala Xaa His Xaa Leu Ile Xaa Gly Leu Glu 
                805                 810                 815     


Glu Tyr Val Arg Glu Ser Phe Ser Leu Val Gln Val Gln Pro Gly Val 
            820                 825                 830         


Asp Ile Ile Arg Xaa Asn Leu Glu Phe Leu Gln Glu Gln Phe Asn Ser 
        835                 840                 845             


Ile Ala Ala His Val Leu His Cys Xaa Asp Ser Gly Phe Gly Ala Arg 
    850                 855                 860                 


Leu Leu Glu Leu Cys Asn Gln Gly Leu Phe Glu Cys Leu Ala Leu Asn 
865                 870                 875                 880 


Leu His Cys Leu Gly Gly Gln Gln Met Glu Leu Ala Ala Val Ile Asn 
                885                 890                 895     


Gly Arg Ile Arg Arg Met Ser Arg Gly Val Asn Pro Ser Leu Val Ser 
            900                 905                 910         


Trp Leu Xaa Xaa Met Met Gly Leu Arg Leu Gln Val Val Leu Glu His 
        915                 920                 925             


Met Pro Val Gly Pro Asp Ala Ile Leu Arg Tyr Val Arg Arg Val Gly 
    930                 935                 940                 


Asp Pro Pro Gln Pro Leu Pro Glu Glu Pro Met Glu Val Gln Gly Ala 
945                 950                 955                 960 


Glu Arg Ala Ser Pro Glu Pro Gln Arg Glu Asn Ala Ser Pro Ala Pro 
                965                 970                 975     


Gly Xaa Xaa Ala Glu Glu Ala Met Ser Arg Gly Pro Pro Pro Ala Pro 
            980                 985                 990         


Glu Gly Gly Ser Arg Asp Glu Gln  Asp Gly Ala Ser Ala  Glu Xaa Glu 
        995                 1000                 1005             


Pro Trp  Ala Ala Ala Val Pro  Pro Glu Trp Val Pro  Ile Ile Gln 
    1010                 1015                 1020             


Gln Asp  Ile Gln Ser Gln Arg  Lys Val Lys Pro Gln  Pro Pro Leu 
    1025                 1030                 1035             


Ser Asp  Ala Tyr Leu Ser Gly  Met Pro Ala Lys Arg  Arg Lys Xaa 
    1040                 1045                 1050             


Met Gln  Gly Glu Gly Pro Gln  Leu Leu Leu Ser Glu  Ala Val Ser 
    1055                 1060                 1065             


Arg Ala  Ala Lys Ala Ala Gly  Ala Arg Pro Leu Xaa  Ser Pro Glu 
    1070                 1075                 1080             


Ser Leu  Ser Arg Asp Leu Glu  Ala Pro Glu Val Gln  Glu Ser Tyr 
    1085                 1090                 1095             


Arg Gln  Gln Leu Arg Ser Asp  Ile Gln Lys Arg Leu  Gln Glu Asp 
    1100                 1105                 1110             


Pro Asn  Tyr Ser Pro Gln Arg  Phe Pro Asn Ala Gln  Arg Ala Phe 
    1115                 1120                 1125             


Ala Asp  Asp Pro 
    1130         


<210> 3853
<211> 206
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<400> 3853
Met Glu Pro Asn Asp Ser Xaa Ser Xaa Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Xaa Leu Asp Ser Gln Xaa Arg Xaa Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Xaa His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Xaa Gly Ser Ala Ser Ala Xaa His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Xaa Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Xaa Phe Asn Leu Pro Ser Glu Pro 
    130                 135                 140                 


Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile Gln Xaa 
145                 150                 155                 160 


Leu Leu Ser Arg Met Glu Cys Arg Gly Gly Pro Gln Pro Gln His Ser 
                165                 170                 175     


Gln Pro Pro Pro Gln Pro Pro Ala Val Xaa Pro Glu Pro Val Ala Leu 
            180                 185                 190         


Ser Ser Gln Xaa Ser Glu Pro Val Glu Ser Glu Ala Pro Pro 
        195                 200                 205     


<210> 3854
<211> 215
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<400> 3854
Met Glu Pro Asn Asp Ser Xaa Ser Xaa Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Xaa Leu Asp Ser Gln Xaa Arg Xaa Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Xaa His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Xaa Gly Ser Ala Ser Ala Xaa His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Xaa Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Xaa Phe Asn Leu Pro Ser Glu Pro 
    130                 135                 140                 


Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile Gln Xaa 
145                 150                 155                 160 


Leu Leu Ser Arg Met Glu Cys Arg Gly Gly Pro Gln Pro Gln His Ser 
                165                 170                 175     


Gln Pro Pro Pro Gln Pro Pro Ala Val Xaa Pro Glu Pro Val Ala Leu 
            180                 185                 190         


Ser Ser Gln Xaa Ser Glu Pro Val Glu Ser Glu Ala Pro Pro Arg Glu 
        195                 200                 205             


Pro Met Glu Ala Glu Glu Val 
    210                 215 


<210> 3855
<211> 244
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<400> 3855
Met Glu Pro Asn Asp Ser Xaa Ser Xaa Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Xaa Leu Asp Ser Gln Xaa Arg Xaa Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Xaa His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Xaa Gly Ser Ala Ser Ala Xaa His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Xaa Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Xaa Phe Asn Leu Pro Ser Glu Pro 
    130                 135                 140                 


Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile Gln Xaa 
145                 150                 155                 160 


Leu Leu Ser Arg Met Glu Cys Arg Gly Gly Pro Gln Pro Gln His Ser 
                165                 170                 175     


Gln Pro Pro Pro Gln Pro Pro Ala Val Xaa Pro Glu Pro Val Ala Leu 
            180                 185                 190         


Ser Ser Gln Xaa Ser Glu Pro Val Glu Ser Glu Ala Pro Pro Arg Glu 
        195                 200                 205             


Pro Met Glu Ala Glu Glu Val Glu Glu Arg Ala Pro Ala Gln Asn Pro 
    210                 215                 220                 


Glu Leu Xaa Pro Gly Pro Ala Pro Ala Gly Pro Xaa Pro Ala Pro Glu 
225                 230                 235                 240 


Xaa Asn Ala Pro 
                


<210> 3856
<211> 245
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<400> 3856
Pro Pro Arg His Leu His Val Val Arg Pro Met Ser His Tyr Xaa Xaa 
1               5                   10                  15      


Pro Met Val Leu Gln Gln Ala Ala Ile Pro Ile Gln Ile Asn Val Gly 
            20                  25                  30          


Xaa Xaa Val Xaa Met Xaa Gly Pro Ala Pro Pro Pro Ala Xaa Ser His 
        35                  40                  45              


Pro Arg Val Ile Arg Ile Ser His Gln Ser Val Glu Pro Val Val Met 
    50                  55                  60                  


Met His Met Asn Ile Gln Asp Ser Gly Xaa Gln Pro Gly Gly Val Pro 
65                  70                  75                  80  


Ser Ala Pro Xaa Gly Pro Leu Gly Pro Pro Gly His Gly Gln Xaa Leu 
                85                  90                  95      


Gly Gln Gln Val Pro Gly Phe Pro Xaa Ala Pro Xaa Arg Val Val Ile 
            100                 105                 110         


Ala Arg Pro Xaa Pro Pro Gln Ala Arg Pro Ser His Pro Gly Gly Pro 
        115                 120                 125             


Pro Val Ser Gly Xaa Leu Gln Gly Ala Gly Leu Gly Xaa Asn Ala Ser 
    130                 135                 140                 


Leu Ala Gln Met Val Ser Gly Leu Val Gly Gln Leu Leu Met Gln Pro 
145                 150                 155                 160 


Val Leu Val Ala Gln Gly Xaa Pro Gly Met Ala Pro Pro Pro Ala Pro 
                165                 170                 175     


Ala Xaa Ala Ser Ala Ser Ala Gly Xaa Xaa Asn Xaa Ala Xaa Xaa Ala 
            180                 185                 190         


Gly Pro Ala Pro Gly Gly Pro Ala Gln Pro Pro Pro Xaa Pro Gln Pro 
        195                 200                 205             


Ser Met Ala Asp Leu Gln Phe Ser Gln Leu Leu Gly Asn Leu Leu Gly 
    210                 215                 220                 


Pro Ala Gly Pro Gly Ala Gly Gly Pro Gly Val Ala Ser Pro Xaa Ile 
225                 230                 235                 240 


Xaa Val Ala Met Pro 
                245 


<210> 3857
<211> 245
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<400> 3857
Pro Pro Arg His Leu His Val Val Arg Pro Met Ser His Tyr Xaa Xaa 
1               5                   10                  15      


Pro Met Val Leu Gln Gln Ala Ala Ile Pro Ile Gln Ile Asn Val Gly 
            20                  25                  30          


Xaa Xaa Val Xaa Met Xaa Gly Pro Ala Pro Pro Pro Ala Xaa Ser His 
        35                  40                  45              


Pro Arg Val Ile Arg Ile Ser His Gln Ser Val Glu Pro Val Val Met 
    50                  55                  60                  


Met His Met Asn Ile Gln Asp Ser Gly Xaa Gln Pro Gly Gly Val Pro 
65                  70                  75                  80  


Ser Ala Pro Xaa Gly Pro Leu Gly Pro Pro Gly His Gly Gln Xaa Leu 
                85                  90                  95      


Gly Gln Gln Val Pro Gly Phe Pro Xaa Ala Pro Xaa Arg Val Val Ile 
            100                 105                 110         


Ala Arg Pro Xaa Pro Pro Gln Ala Arg Pro Ser His Pro Gly Gly Pro 
        115                 120                 125             


Pro Val Ser Gly Xaa Leu Gln Gly Ala Gly Leu Gly Xaa Asn Ala Ser 
    130                 135                 140                 


Leu Ala Gln Met Val Ser Gly Leu Val Gly Gln Leu Leu Met Gln Pro 
145                 150                 155                 160 


Val Leu Val Ala Gln Gly Xaa Pro Gly Met Ala Pro Pro Pro Ala Pro 
                165                 170                 175     


Ala Xaa Ala Ser Ala Ser Ala Gly Xaa Xaa Asn Xaa Ala Xaa Xaa Ala 
            180                 185                 190         


Gly Pro Ala Pro Gly Gly Pro Ala Gln Pro Pro Pro Xaa Pro Gln Pro 
        195                 200                 205             


Ser Met Ala Asp Leu Gln Phe Ser Gln Leu Leu Gly Asn Leu Leu Gly 
    210                 215                 220                 


Pro Ala Gly Pro Gly Ala Gly Gly Ser Gly Val Ala Ser Pro Xaa Ile 
225                 230                 235                 240 


Xaa Val Ala Met Pro 
                245 


<210> 3858
<211> 238
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<400> 3858
Ser Ser Ala Glu Gly Ala Pro Pro Pro Gly Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


Xaa Ser His Pro Arg Val Ile Arg Ile Ser His Gln Ser Val Glu Pro 
            20                  25                  30          


Val Val Met Met His Met Asn Ile Gln Gly Pro Leu Ser Leu Ser Pro 
        35                  40                  45              


Cys Pro Asp Ser Gly Xaa Gln Pro Gly Gly Val Pro Ser Ala Pro Xaa 
    50                  55                  60                  


Gly Pro Leu Gly Pro Pro Gly His Gly Gln Xaa Leu Gly Gln Gln Val 
65                  70                  75                  80  


Pro Gly Phe Pro Xaa Ala Pro Xaa Arg Val Val Ile Ala Arg Pro Xaa 
                85                  90                  95      


Pro Pro Gln Ala Arg Pro Ser His Pro Gly Gly Pro Pro Val Ser Gly 
            100                 105                 110         


Xaa Leu Gln Gly Ala Gly Leu Gly Xaa Asn Ala Ser Leu Ala Gln Met 
        115                 120                 125             


Val Ser Gly Leu Val Gly Gln Leu Leu Met Gln Pro Val Leu Val Ala 
    130                 135                 140                 


Gln Gly Xaa Pro Gly Met Ala Pro Pro Pro Ala Pro Ala Xaa Ala Ser 
145                 150                 155                 160 


Ala Ser Ala Gly Xaa Xaa Asn Xaa Ala Xaa Xaa Ala Gly Pro Ala Pro 
                165                 170                 175     


Gly Gly Pro Ala Gln Pro Pro Pro Xaa Pro Gln Pro Ser Met Ala Asp 
            180                 185                 190         


Leu Gln Phe Ser Gln Leu Leu Gly Asn Leu Leu Gly Pro Ala Gly Pro 
        195                 200                 205             


Gly Ala Gly Gly Pro Gly Val Ala Ser Pro Xaa Ile Xaa Val Ala Met 
    210                 215                 220                 


Pro Gly Val Pro Ala Phe Leu Gln Gly Met Xaa Asp Phe Leu 
225                 230                 235             


<210> 3859
<211> 238
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<400> 3859
Ser Ser Ala Glu Gly Ala Pro Pro Pro Gly Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


Xaa Ser His Pro Arg Val Ile Arg Ile Ser His Gln Ser Val Glu Pro 
            20                  25                  30          


Val Val Met Met His Met Asn Ile Gln Gly Pro Leu Ser Leu Ser Pro 
        35                  40                  45              


Cys Pro Asp Ser Gly Xaa Gln Pro Gly Gly Val Pro Ser Ala Pro Xaa 
    50                  55                  60                  


Gly Pro Leu Gly Pro Pro Gly His Gly Gln Xaa Leu Gly Gln Gln Val 
65                  70                  75                  80  


Pro Gly Phe Pro Xaa Ala Pro Xaa Arg Val Val Ile Ala Arg Pro Xaa 
                85                  90                  95      


Pro Pro Gln Ala Arg Pro Ser His Pro Gly Gly Pro Pro Val Ser Gly 
            100                 105                 110         


Xaa Leu Gln Gly Ala Gly Leu Gly Xaa Asn Ala Ser Leu Ala Gln Met 
        115                 120                 125             


Val Ser Gly Leu Val Gly Gln Leu Leu Met Gln Pro Val Leu Val Ala 
    130                 135                 140                 


Gln Gly Xaa Pro Gly Met Ala Pro Pro Pro Ala Pro Ala Xaa Ala Ser 
145                 150                 155                 160 


Ala Ser Ala Gly Xaa Xaa Asn Xaa Ala Xaa Xaa Ala Gly Pro Ala Pro 
                165                 170                 175     


Gly Gly Pro Ala Gln Pro Pro Pro Xaa Pro Gln Pro Ser Met Ala Asp 
            180                 185                 190         


Leu Gln Phe Ser Gln Leu Leu Gly Asn Leu Leu Gly Pro Ala Gly Pro 
        195                 200                 205             


Gly Ala Gly Gly Ser Gly Val Ala Ser Pro Xaa Ile Xaa Val Ala Met 
    210                 215                 220                 


Pro Gly Val Pro Ala Phe Leu Gln Gly Met Xaa Asp Phe Leu 
225                 230                 235             


<210> 3860
<211> 185
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 3860
Xaa Leu Ala Cys Xaa Pro Pro Arg His Leu His Val Val Arg Pro Met 
1               5                   10                  15      


Ser His Tyr Xaa Xaa Pro Met Val Leu Gln Gln Ala Ala Ile Pro Ile 
            20                  25                  30          


Gln Ile Asn Val Gly Xaa Xaa Val Xaa Met Xaa Gly Asn Gly Xaa Arg 
        35                  40                  45              


Pro Pro Pro Xaa Pro Asn Ala Glu Ala Pro Pro Pro Gly Pro Gly Gln 
    50                  55                  60                  


Ala Ser Ser Val Ala Pro Ser Ser Xaa Asn Val Glu Ser Ser Ala Glu 
65                  70                  75                  80  


Gly Ala Pro Pro Pro Gly Pro Ala Pro Pro Pro Ala Xaa Ser His Pro 
                85                  90                  95      


Arg Val Ile Arg Ile Ser His Gln Ser Val Glu Pro Val Val Met Met 
            100                 105                 110         


His Met Asn Ile Gln Gly Gln Gln Val Pro Gly Phe Pro Xaa Ala Pro 
        115                 120                 125             


Xaa Arg Val Val Ile Ala Arg Pro Xaa Pro Pro Gln Ala Arg Pro Ser 
    130                 135                 140                 


His Pro Gly Gly Pro Pro Val Ser Gly Xaa Leu Gln Gly Ala Gly Leu 
145                 150                 155                 160 


Gly Xaa Asn Ala Ser Leu Ala Gln Met Val Ser Gly Leu Val Gly Gln 
                165                 170                 175     


Leu Leu Met Gln Pro Val Leu Val Ala 
            180                 185 


<210> 3861
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(17)
<223> Selenocysteine

<400> 3861
Xaa Arg Met Ser Arg Gly Val Asn Pro Ser Leu Val Ser Trp Leu Xaa 
1               5                   10                  15      


Xaa Met Met Gly Leu Arg Leu Gln Val Val Leu Glu His Met Pro Val 
            20                  25                  30          


Gly Pro Asp Ala Ile Leu Arg Tyr Val Arg Arg Val Gly Asp Pro Pro 
        35                  40                  45              


Gln Pro Leu Pro Glu Glu Pro Met Glu Val Gln Gly Ala Glu Arg Ala 
    50                  55                  60                  


Ser Pro Glu Pro Gln Glu Trp Val Pro Ile Ile Gln Gln Asp Ile Gln 
65                  70                  75                  80  


Ser Gln Arg Lys Val Lys Pro Gln Pro Pro Leu Ser Asp Ala Tyr Leu 
                85                  90                  95      


Ser Gly Met Pro Ala Lys Arg Arg Lys Leu Arg Ser Asp Ile Gln Lys 
            100                 105                 110         


Arg Leu Gln Glu Asp Pro Asn Tyr Ser Pro Gln Arg Phe Pro Asn Ala 
        115                 120                 125             


Gln Arg Ala Phe Ala Asp Asp Pro 
    130                 135     


<210> 3862
<211> 226
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (58)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 3862
Xaa Ser Gly Phe Gly Ala Arg Leu Leu Glu Leu Cys Asn Gln Gly Leu 
1               5                   10                  15      


Phe Glu Cys Leu Ala Leu Asn Leu His Cys Leu Gly Gly Gln Gln Met 
            20                  25                  30          


Glu Leu Ala Ala Val Ile Asn Gly Arg Ile Arg Arg Met Ser Arg Gly 
        35                  40                  45              


Val Asn Pro Ser Leu Val Ser Trp Leu Xaa Xaa Met Met Gly Leu Arg 
    50                  55                  60                  


Leu Gln Val Val Leu Glu His Met Pro Val Gly Pro Asp Ala Ile Leu 
65                  70                  75                  80  


Arg Tyr Val Arg Arg Val Gly Asp Pro Pro Gln Pro Leu Pro Glu Glu 
                85                  90                  95      


Pro Met Glu Val Gln Gly Ala Glu Arg Ala Ser Pro Glu Pro Gln Arg 
            100                 105                 110         


Glu Asn Ala Ser Pro Ala Pro Gly Xaa Xaa Ala Glu Glu Ala Met Ser 
        115                 120                 125             


Arg Gly Pro Pro Pro Ala Pro Glu Gly Gly Ser Arg Asp Glu Gln Asp 
    130                 135                 140                 


Gly Ala Ser Ala Glu Xaa Glu Pro Trp Ala Ala Ala Val Pro Pro Glu 
145                 150                 155                 160 


Trp Val Pro Ile Ile Gln Gln Asp Ile Gln Ser Gln Arg Lys Val Lys 
                165                 170                 175     


Pro Gln Pro Pro Leu Ser Asp Ala Tyr Leu Ser Gly Met Pro Ala Lys 
            180                 185                 190         


Arg Arg Lys Leu Arg Ser Asp Ile Gln Lys Arg Leu Gln Glu Asp Pro 
        195                 200                 205             


Asn Tyr Ser Pro Gln Arg Phe Pro Asn Ala Gln Arg Ala Phe Ala Asp 
    210                 215                 220                 


Asp Pro 
225     


<210> 3863
<211> 140
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<400> 3863
Met Glu Gln Phe Asn Pro Ser Leu Arg Asn Phe Ile Ala Met Gly Lys 
1               5                   10                  15      


Asn Tyr Glu Lys Ala Leu Ala Gly Val Xaa Tyr Ala Ala Lys Gly Tyr 
            20                  25                  30          


Phe Asp Ala Leu Val Lys Met Gly Glu Leu Ala Ser Glu Ser Gln Gly 
        35                  40                  45              


Ser Lys Glu Leu Gly Asp Val Leu Phe Gln Met Ala Glu Val His Arg 
    50                  55                  60                  


Gln Ile Gln Asn Gln Leu Glu Glu Met Leu Lys Ser Phe His Asn Glu 
65                  70                  75                  80  


Leu Leu Xaa Gln Leu Glu Gln Lys Val Glu Leu Asp Ser Arg Tyr Leu 
                85                  90                  95      


Ser Ala Ala Leu Lys Lys Tyr Gln Xaa Glu Gln Arg Ser Lys Gly Asp 
            100                 105                 110         


Ala Leu Asp Lys Cys Gln Ala Glu Leu Lys Lys Leu Arg Lys Lys Ser 
        115                 120                 125             


Gln Gly Ser Lys Asn Pro Gln Lys Tyr Ser Asp Lys 
    130                 135                 140 


<210> 3864
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<400> 3864
Met Glu Gln Phe Asn Pro Ser Leu Arg Asn Phe Ile Ala Met Gly Lys 
1               5                   10                  15      


Asn Tyr Glu Lys Ala Leu Ala Gly Val Xaa Tyr Ala Ala Lys Gly Tyr 
            20                  25                  30          


Phe Asp Ala Leu Val Lys Met Gly Glu Leu Ala Ser Glu Ser Gln Gly 
        35                  40                  45              


Ser Lys Glu Leu Gly Asp Val Leu Phe Gln Met Ala Glu Val His Arg 
    50                  55                  60                  


Gln Ile Gln Asn Gln Leu Glu Glu Met Leu Lys Ser Phe His Asn Glu 
65                  70                  75                  80  


Leu Leu Xaa Gln Leu Glu Gln Lys Val Glu Leu Asp Ser Arg Tyr Leu 
                85                  90                  95      


Ser Ala Ala Leu Lys Lys Tyr Gln Xaa Glu Gln Arg Ser Lys Gly Asp 
            100                 105                 110         


Ala Leu Asp Lys Cys Gln Ala Glu Leu Lys Lys Leu Arg Lys Lys Ser 
        115                 120                 125             


Gln Gly Ser Lys Asn Pro Gln Lys Tyr Ser Asp Lys Glu Leu Gln Tyr 
    130                 135                 140                 


Ile Asp Ala Ile Ser Asn Lys Gln Gly Glu Leu Glu Asn Tyr Val Ser 
145                 150                 155                 160 


Asp Gly Tyr Lys Xaa Ala Leu Xaa Glu Glu Arg Arg Arg Phe Cys 
                165                 170                 175 


<210> 3865
<211> 58
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<400> 3865
Met Gly Glu Leu Ala Ser Glu Ser Gln Gly Ser Lys Glu Leu Gly Asp 
1               5                   10                  15      


Val Leu Phe Gln Met Ala Glu Val His Arg Gln Ile Gln Asn Gln Leu 
            20                  25                  30          


Glu Glu Met Leu Lys Ser Phe His Asn Glu Leu Leu Xaa Gln Leu Glu 
        35                  40                  45              


Gln Lys Val Glu Leu Asp Ser Arg Leu Arg 
    50                  55              


<210> 3866
<211> 79
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<400> 3866
Met Gly Glu Leu Ala Ser Glu Ser Gln Gly Ser Lys Glu Leu Gly Asp 
1               5                   10                  15      


Val Leu Phe Gln Met Ala Glu Val His Arg Gln Ile Gln Asn Gln Leu 
            20                  25                  30          


Glu Glu Met Leu Lys Ser Phe His Asn Glu Leu Leu Xaa Gln Leu Glu 
        35                  40                  45              


Gln Lys Val Glu Leu Asp Ser Arg Tyr Leu Ser Ala Ala Leu Lys Lys 
    50                  55                  60                  


Tyr Gln Xaa Glu Gln Arg Ser Lys Gly Asp Ala Leu Asp Lys Cys 
65                  70                  75                  


<210> 3867
<211> 114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<400> 3867
Met Gly Glu Leu Ala Ser Glu Ser Gln Gly Ser Lys Glu Leu Gly Asp 
1               5                   10                  15      


Val Leu Phe Gln Met Ala Glu Val His Arg Gln Ile Gln Asn Gln Leu 
            20                  25                  30          


Glu Glu Met Leu Lys Ser Phe His Asn Glu Leu Leu Xaa Gln Leu Glu 
        35                  40                  45              


Gln Lys Val Glu Leu Asp Ser Arg Tyr Leu Ser Ala Ala Leu Lys Lys 
    50                  55                  60                  


Tyr Gln Xaa Glu Gln Arg Ser Lys Gly Asp Ala Leu Asp Lys Cys Gln 
65                  70                  75                  80  


Ala Glu Leu Lys Lys Leu Arg Lys Lys Ser Gln Gly Ser Lys Asn Pro 
                85                  90                  95      


Gln Lys Tyr Ser Asp Lys Glu Leu Gln Tyr Ile Asp Ala Ile Ser Asn 
            100                 105                 110         


Lys Gln 
        


<210> 3868
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 3868
Met Gly Glu Leu Ala Ser Glu Ser Gln Gly Ser Lys Glu Leu Gly Asp 
1               5                   10                  15      


Val Leu Phe Gln Met Ala Glu Val His Arg Gln Ile Gln Asn Gln Leu 
            20                  25                  30          


Glu Glu Met Leu Lys Ser Phe His Asn Glu Leu Leu Xaa Gln Leu Glu 
        35                  40                  45              


Gln Lys Val Glu Leu Asp Ser Arg Tyr Leu Ser Ala Ala Leu Lys Lys 
    50                  55                  60                  


Tyr Gln Xaa Glu Gln Arg Ser Lys Gly Asp Ala Leu Asp Lys Cys Gln 
65                  70                  75                  80  


Ala Glu Leu Lys Lys Leu Arg Lys Lys Ser Gln Gly Ser Lys Asn Pro 
                85                  90                  95      


Gln Lys Tyr Ser Asp Lys Glu Leu Gln Tyr Ile Asp Ala Ile Ser Asn 
            100                 105                 110         


Lys Gln Gly Glu Leu Glu Asn Tyr Val Ser Asp Gly Tyr Lys Xaa Ala 
        115                 120                 125             


Leu Xaa Glu Glu Arg Arg Arg 
    130                 135 


<210> 3869
<211> 180
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 3869
Met Gly Glu Leu Ala Ser Glu Ser Gln Gly Ser Lys Glu Leu Gly Asp 
1               5                   10                  15      


Val Leu Phe Gln Met Ala Glu Val His Arg Gln Ile Gln Asn Gln Leu 
            20                  25                  30          


Glu Glu Met Leu Lys Ser Phe His Asn Glu Leu Leu Xaa Gln Leu Glu 
        35                  40                  45              


Gln Lys Val Glu Leu Asp Ser Arg Tyr Leu Ser Ala Ala Leu Lys Lys 
    50                  55                  60                  


Tyr Gln Xaa Glu Gln Arg Ser Lys Gly Asp Ala Leu Asp Lys Cys Gln 
65                  70                  75                  80  


Ala Glu Leu Lys Lys Leu Arg Lys Lys Ser Gln Gly Ser Lys Asn Pro 
                85                  90                  95      


Gln Lys Tyr Ser Asp Lys Glu Leu Gln Tyr Ile Asp Ala Ile Ser Asn 
            100                 105                 110         


Lys Gln Gly Glu Leu Glu Asn Tyr Val Ser Asp Gly Tyr Lys Xaa Ala 
        115                 120                 125             


Leu Xaa Glu Glu Arg Arg Arg Phe Cys Phe Leu Val Glu Lys Gln Cys 
    130                 135                 140                 


Ala Val Ala Lys Asn Ser Ala Ala Tyr His Ser Lys Gly Lys Glu Leu 
145                 150                 155                 160 


Leu Ala Gln Lys Leu Pro Leu Trp Gln Gln Ala Cys Ala Asp Pro Ser 
                165                 170                 175     


Lys Ile Pro Glu 
            180 


<210> 3870
<211> 234
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<400> 3870
Met Gly Glu Leu Ala Ser Glu Ser Gln Gly Ser Lys Glu Leu Gly Asp 
1               5                   10                  15      


Val Leu Phe Gln Met Ala Glu Val His Arg Gln Ile Gln Asn Gln Leu 
            20                  25                  30          


Glu Glu Met Leu Lys Ser Phe His Asn Glu Leu Leu Xaa Gln Leu Glu 
        35                  40                  45              


Gln Lys Val Glu Leu Asp Ser Arg Tyr Leu Ser Ala Ala Leu Lys Lys 
    50                  55                  60                  


Tyr Gln Xaa Glu Gln Arg Ser Lys Gly Asp Ala Leu Asp Lys Cys Gln 
65                  70                  75                  80  


Ala Glu Leu Lys Lys Leu Arg Lys Lys Ser Gln Gly Ser Lys Asn Pro 
                85                  90                  95      


Gln Lys Tyr Ser Asp Lys Glu Leu Gln Tyr Ile Asp Ala Ile Ser Asn 
            100                 105                 110         


Lys Gln Gly Glu Leu Glu Asn Tyr Val Ser Asp Gly Tyr Lys Xaa Ala 
        115                 120                 125             


Leu Xaa Glu Glu Arg Arg Arg Phe Cys Phe Leu Val Glu Lys Gln Cys 
    130                 135                 140                 


Ala Val Ala Lys Asn Ser Ala Ala Tyr His Ser Lys Gly Lys Glu Leu 
145                 150                 155                 160 


Leu Ala Gln Lys Leu Pro Leu Trp Gln Gln Ala Cys Ala Asp Pro Ser 
                165                 170                 175     


Lys Ile Pro Glu Arg Ala Val Gln Leu Met Gln Gln Val Ala Ser Asn 
            180                 185                 190         


Gly Ala Xaa Leu Pro Ser Ala Leu Ser Ala Ser Lys Ser Asn Leu Val 
        195                 200                 205             


Ile Ser Asp Pro Ile Pro Gly Ala Lys Pro Leu Pro Val Pro Pro Glu 
    210                 215                 220                 


Leu Ala Pro Phe Val Gly Arg Met Ser Ala 
225                 230                 


<210> 3871
<211> 375
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<400> 3871
Met Leu Leu Pro Glu Gly Gln Arg Gln Arg Ala Leu Gly Phe Gly Xaa 
1               5                   10                  15      


Val Xaa Ser Xaa Tyr Ser Pro Val Gly Gln Tyr Ile Asp Ala Ile Ser 
            20                  25                  30          


Asn Lys Gln Gly Glu Leu Glu Asn Tyr Val Ser Asp Gly Tyr Lys Xaa 
        35                  40                  45              


Ala Leu Xaa Glu Glu Arg Arg Arg Phe Cys Phe Leu Val Glu Lys Gln 
    50                  55                  60                  


Cys Ala Val Ala Lys Asn Ser Ala Ala Tyr His Ser Lys Gly Lys Glu 
65                  70                  75                  80  


Leu Leu Ala Gln Lys Leu Pro Leu Trp Gln Gln Ala Cys Ala Asp Pro 
                85                  90                  95      


Ser Lys Ile Pro Glu Arg Ala Val Gln Leu Met Gln Gln Val Ala Ser 
            100                 105                 110         


Asn Gly Ala Xaa Leu Pro Ser Ala Leu Ser Ala Ser Lys Ser Asn Leu 
        115                 120                 125             


Val Ile Ser Asp Pro Ile Pro Gly Ala Lys Pro Leu Pro Val Pro Pro 
    130                 135                 140                 


Glu Leu Ala Pro Phe Val Gly Arg Met Ser Ala Gln Glu Ser Xaa Pro 
145                 150                 155                 160 


Ile Met Asn Gly Val Xaa Gly Pro Asp Gly Glu Asp Tyr Ser Pro Trp 
                165                 170                 175     


Ala Asp Arg Lys Ala Ala Gln Pro Lys Ser Leu Ser Pro Pro Gln Ser 
            180                 185                 190         


Gln Ser Lys Leu Ser Asp Ser Tyr Ser Asn Xaa Leu Pro Val Arg Lys 
        195                 200                 205             


Ser Val Xaa Pro Lys Asn Ser Tyr Ala Xaa Xaa Glu Asn Lys Xaa Leu 
    210                 215                 220                 


Pro Arg Ser Ser Ser Met Ala Ala Gly Leu Glu Arg Asn Gly Arg Met 
225                 230                 235                 240 


Arg Val Lys Ala Ile Phe Ser His Ala Ala Gly Asp Asn Ser Xaa Leu 
                245                 250                 255     


Leu Ser Phe Lys Glu Gly Asp Leu Ile Xaa Leu Leu Val Pro Glu Ala 
            260                 265                 270         


Arg Asp Gly Trp His Tyr Gly Glu Ser Glu Lys Xaa Lys Met Arg Gly 
        275                 280                 285             


Trp Phe Pro Phe Ser Tyr Xaa Arg Val Leu Asp Ser Asp Gly Ser Asp 
    290                 295                 300                 


Arg Leu His Met Ser Leu Gln Gln Gly Lys Ser Ser Ser Xaa Gly Asn 
305                 310                 315                 320 


Leu Leu Asp Lys Asp Asp Leu Ala Ile Pro Pro Pro Asp Tyr Gly Ala 
                325                 330                 335     


Ala Ser Arg Ala Phe Pro Ala Gln Xaa Ala Ser Gly Phe Lys Gln Arg 
            340                 345                 350         


Pro Tyr Ser Val Ala Val Pro Ala Phe Ser Gln Gly Leu Asp Asp Tyr 
        355                 360                 365             


Gly Ala Arg Ser Met Ser Arg 
    370                 375 


<210> 3872
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 3872
Met Gln Gln Val Ala Ser Asn Gly Ala Xaa Leu Pro Ser Ala Leu Ser 
1               5                   10                  15      


Ala Ser Lys Ser Asn Leu Val Ile Ser Asp Pro Ile Pro Gly Ala Lys 
            20                  25                  30          


Pro Leu Pro Val Pro Pro Glu Leu Ala Pro Phe Val Gly Arg Met Ser 
        35                  40                  45              


Ala Gln Glu Ser Xaa Pro Ile Met Asn Gly Val Xaa Gly Pro Asp Gly 
    50                  55                  60                  


Glu Asp Tyr Ser Pro Trp Ala Asp Arg Lys Ala Ala Gln Pro Lys Ser 
65                  70                  75                  80  


Leu Ser Pro Pro Gln Ser Gln Ser Lys Leu Ser Asp Ser Tyr Ser Asn 
                85                  90                  95      


Xaa Leu Pro Val Arg Lys Ser Val Xaa Pro Lys Asn Ser Tyr Ala Xaa 
            100                 105                 110         


Xaa Glu Asn Lys Xaa Leu Pro Arg Ser Ser Ser Met Ala Ala Gly Leu 
        115                 120                 125             


Glu Arg 
    130 


<210> 3873
<211> 149
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 3873
Met Ser Leu Ser Arg Ser Glu Glu Met His Arg Leu Xaa Glu Asn Val 
1               5                   10                  15      


Tyr Lys Arg Val Glu Glu Lys Tyr Gln Arg Asn Leu Phe Pro Ile Phe 
            20                  25                  30          


Ser Pro Ser Ala Leu Lys Pro Glu Ser Arg Asn Phe Arg Gly Glu Ser 
        35                  40                  45              


Trp Gln Gly Xaa Ile Met Glu Gln Phe Asn Pro Ser Leu Arg Asn Phe 
    50                  55                  60                  


Ile Ala Met Gly Lys Asn Tyr Glu Lys Ala Leu Ala Gly Val Xaa Tyr 
65                  70                  75                  80  


Ala Ala Lys Gly Tyr Phe Asp Ala Leu Val Lys Met Gly Glu Leu Ala 
                85                  90                  95      


Ser Glu Ser Gln Gly Ser Lys Glu Leu Gly Asp Val Leu Phe Gln Met 
            100                 105                 110         


Ala Glu Val His Arg Gln Ile Gln Asn Gln Leu Glu Glu Met Leu Lys 
        115                 120                 125             


Ser Phe His Asn Glu Leu Leu Xaa Gln Leu Glu Gln Lys Val Glu Leu 
    130                 135                 140                 


Asp Ser Arg Leu Arg 
145                 


<210> 3874
<211> 553
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<400> 3874
Met Ser Leu Ser Arg Ser Glu Glu Met His Arg Leu Xaa Glu Asn Val 
1               5                   10                  15      


Tyr Lys Arg Val Glu Glu Lys Tyr Gln Arg Asn Leu Phe Pro Ile Phe 
            20                  25                  30          


Ser Pro Ser Ala Leu Lys Pro Glu Ser Arg Asn Phe Arg Gly Glu Ser 
        35                  40                  45              


Trp Gln Gly Xaa Ile Met Glu Gln Phe Asn Pro Ser Leu Arg Asn Phe 
    50                  55                  60                  


Ile Ala Met Gly Lys Asn Tyr Glu Lys Ala Leu Ala Gly Val Xaa Tyr 
65                  70                  75                  80  


Ala Ala Lys Gly Tyr Phe Asp Ala Leu Val Lys Met Gly Glu Leu Ala 
                85                  90                  95      


Ser Glu Ser Gln Gly Ser Lys Glu Leu Gly Asp Val Leu Phe Gln Met 
            100                 105                 110         


Ala Glu Val His Arg Gln Ile Gln Asn Gln Leu Glu Glu Met Leu Lys 
        115                 120                 125             


Ser Phe His Asn Glu Leu Leu Xaa Gln Leu Glu Gln Lys Val Glu Leu 
    130                 135                 140                 


Asp Ser Arg Tyr Leu Ser Ala Ala Leu Lys Lys Tyr Gln Xaa Glu Gln 
145                 150                 155                 160 


Arg Ser Lys Gly Asp Ala Leu Asp Lys Cys Gln Ala Glu Leu Lys Lys 
                165                 170                 175     


Leu Arg Lys Lys Ser Gln Gly Ser Lys Asn Pro Gln Lys Tyr Ser Asp 
            180                 185                 190         


Lys Glu Leu Gln Tyr Ile Asp Ala Ile Ser Asn Lys Gln Gly Glu Leu 
        195                 200                 205             


Glu Asn Tyr Val Ser Asp Gly Tyr Lys Xaa Ala Leu Xaa Glu Glu Arg 
    210                 215                 220                 


Arg Arg Phe Cys Phe Leu Val Glu Lys Gln Cys Ala Val Ala Lys Asn 
225                 230                 235                 240 


Ser Ala Ala Tyr His Ser Lys Gly Lys Glu Leu Leu Ala Gln Lys Leu 
                245                 250                 255     


Pro Leu Trp Gln Gln Ala Cys Ala Asp Pro Ser Lys Ile Pro Glu Arg 
            260                 265                 270         


Ala Val Gln Leu Met Gln Gln Val Ala Ser Asn Gly Ala Xaa Leu Pro 
        275                 280                 285             


Ser Ala Leu Ser Ala Ser Lys Ser Asn Leu Val Ile Ser Asp Pro Ile 
    290                 295                 300                 


Pro Gly Ala Lys Pro Leu Pro Val Pro Pro Glu Leu Ala Pro Phe Val 
305                 310                 315                 320 


Gly Arg Met Ser Ala Gln Glu Ser Xaa Pro Ile Met Asn Gly Val Xaa 
                325                 330                 335     


Gly Pro Asp Gly Glu Asp Tyr Ser Pro Trp Ala Asp Arg Lys Ala Ala 
            340                 345                 350         


Gln Pro Lys Ser Leu Ser Pro Pro Gln Ser Gln Ser Lys Leu Ser Asp 
        355                 360                 365             


Ser Tyr Ser Asn Xaa Leu Pro Val Arg Lys Ser Val Xaa Pro Lys Asn 
    370                 375                 380                 


Ser Tyr Ala Xaa Xaa Glu Asn Lys Xaa Leu Pro Arg Ser Ser Ser Met 
385                 390                 395                 400 


Ala Ala Gly Leu Glu Arg Asn Gly Arg Met Arg Val Lys Ala Ile Phe 
                405                 410                 415     


Ser His Ala Ala Gly Asp Asn Ser Xaa Leu Leu Ser Phe Lys Glu Gly 
            420                 425                 430         


Asp Leu Ile Xaa Leu Leu Val Pro Glu Ala Arg Asp Gly Trp His Tyr 
        435                 440                 445             


Gly Glu Ser Glu Lys Xaa Lys Met Arg Gly Trp Phe Pro Phe Ser Tyr 
    450                 455                 460                 


Xaa Arg Val Leu Asp Ser Asp Gly Ser Asp Arg Leu His Met Ser Leu 
465                 470                 475                 480 


Gln Gln Gly Lys Ser Ser Ser Xaa Gly Asn Leu Leu Asp Lys Asp Asp 
                485                 490                 495     


Leu Ala Ile Pro Pro Pro Asp Tyr Gly Ala Ala Ser Arg Ala Phe Pro 
            500                 505                 510         


Ala Gln Xaa Ala Ser Gly Phe Lys Gln Arg Pro Tyr Ser Val Ala Val 
        515                 520                 525             


Pro Ala Phe Ser Gln Gly Leu Asp Asp Tyr Gly Ala Arg Ser Met Ser 
    530                 535                 540                 


Ser Ala Asp Val Glu Val Ala Arg Phe 
545                 550             


<210> 3875
<211> 512
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<400> 3875
Met Ser Leu Ser Arg Ser Glu Glu Met His Arg Leu Xaa Glu Asn Val 
1               5                   10                  15      


Tyr Lys Xaa Ile Met Glu Gln Phe Asn Pro Ser Leu Arg Asn Phe Ile 
            20                  25                  30          


Ala Met Gly Lys Asn Tyr Glu Lys Ala Leu Ala Gly Val Xaa Tyr Ala 
        35                  40                  45              


Ala Lys Gly Tyr Phe Asp Ala Leu Val Lys Met Gly Glu Leu Ala Ser 
    50                  55                  60                  


Glu Ser Gln Gly Ser Lys Glu Leu Gly Asp Val Leu Phe Gln Met Ala 
65                  70                  75                  80  


Glu Val His Arg Gln Ile Gln Asn Gln Leu Glu Glu Met Leu Lys Ser 
                85                  90                  95      


Phe His Asn Glu Leu Leu Xaa Gln Leu Glu Gln Lys Val Glu Leu Asp 
            100                 105                 110         


Ser Arg Tyr Leu Ser Ala Ala Leu Lys Lys Tyr Gln Xaa Glu Gln Arg 
        115                 120                 125             


Ser Lys Gly Asp Ala Leu Asp Lys Cys Gln Ala Glu Leu Lys Lys Leu 
    130                 135                 140                 


Arg Lys Lys Ser Gln Gly Ser Lys Asn Pro Gln Lys Tyr Ser Asp Lys 
145                 150                 155                 160 


Glu Leu Gln Tyr Ile Asp Ala Ile Ser Asn Lys Gln Gly Glu Leu Glu 
                165                 170                 175     


Asn Tyr Val Ser Asp Gly Tyr Lys Xaa Ala Leu Xaa Glu Glu Arg Arg 
            180                 185                 190         


Arg Phe Cys Phe Leu Val Glu Lys Gln Cys Ala Val Ala Lys Asn Ser 
        195                 200                 205             


Ala Ala Tyr His Ser Lys Gly Lys Glu Leu Leu Ala Gln Lys Leu Pro 
    210                 215                 220                 


Leu Trp Gln Gln Ala Cys Ala Asp Pro Ser Lys Ile Pro Glu Arg Ala 
225                 230                 235                 240 


Val Gln Leu Met Gln Gln Val Ala Ser Asn Gly Ala Xaa Leu Pro Ser 
                245                 250                 255     


Ala Leu Ser Ala Ser Lys Ser Asn Leu Val Ile Ser Asp Pro Ile Pro 
            260                 265                 270         


Gly Ala Lys Pro Leu Pro Val Pro Pro Glu Leu Ala Pro Phe Val Gly 
        275                 280                 285             


Arg Met Ser Ala Gln Glu Ser Xaa Pro Ile Met Asn Gly Val Xaa Gly 
    290                 295                 300                 


Pro Asp Gly Glu Asp Tyr Ser Pro Trp Ala Asp Arg Lys Ala Ala Gln 
305                 310                 315                 320 


Pro Lys Ser Leu Ser Pro Pro Gln Ser Gln Ser Lys Leu Ser Asp Ser 
                325                 330                 335     


Tyr Ser Asn Xaa Leu Pro Val Arg Lys Ser Val Xaa Pro Lys Asn Ser 
            340                 345                 350         


Tyr Ala Xaa Xaa Glu Asn Lys Xaa Leu Pro Arg Ser Ser Ser Met Ala 
        355                 360                 365             


Ala Gly Leu Glu Arg Asn Gly Arg Met Arg Val Lys Ala Ile Phe Ser 
    370                 375                 380                 


His Ala Ala Gly Asp Asn Ser Xaa Leu Leu Ser Phe Lys Glu Gly Asp 
385                 390                 395                 400 


Leu Ile Xaa Leu Leu Val Pro Glu Ala Arg Asp Gly Trp His Tyr Gly 
                405                 410                 415     


Glu Ser Glu Lys Xaa Lys Met Arg Gly Trp Phe Pro Phe Ser Tyr Xaa 
            420                 425                 430         


Arg Val Leu Asp Ser Asp Gly Ser Asp Arg Leu His Met Ser Leu Gln 
        435                 440                 445             


Gln Gly Lys Ser Ser Ser Xaa Gly Asn Leu Leu Asp Lys Asp Asp Leu 
    450                 455                 460                 


Ala Ile Pro Pro Pro Asp Tyr Gly Ala Ala Ser Arg Ala Phe Pro Ala 
465                 470                 475                 480 


Gln Xaa Ala Ser Gly Phe Lys Gln Arg Pro Tyr Ser Val Ala Val Pro 
                485                 490                 495     


Ala Phe Ser Gln Gly Leu Asp Asp Tyr Gly Ala Arg Ser Met Ser Arg 
            500                 505                 510         


<210> 3876
<211> 520
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<400> 3876
Met Ser Leu Ser Arg Ser Glu Glu Met His Arg Leu Xaa Glu Asn Val 
1               5                   10                  15      


Tyr Lys Xaa Ile Met Glu Gln Phe Asn Pro Ser Leu Arg Asn Phe Ile 
            20                  25                  30          


Ala Met Gly Lys Asn Tyr Glu Lys Ala Leu Ala Gly Val Xaa Tyr Ala 
        35                  40                  45              


Ala Lys Gly Tyr Phe Asp Ala Leu Val Lys Met Gly Glu Leu Ala Ser 
    50                  55                  60                  


Glu Ser Gln Gly Ser Lys Glu Leu Gly Asp Val Leu Phe Gln Met Ala 
65                  70                  75                  80  


Glu Val His Arg Gln Ile Gln Asn Gln Leu Glu Glu Met Leu Lys Ser 
                85                  90                  95      


Phe His Asn Glu Leu Leu Xaa Gln Leu Glu Gln Lys Val Glu Leu Asp 
            100                 105                 110         


Ser Arg Tyr Leu Ser Ala Ala Leu Lys Lys Tyr Gln Xaa Glu Gln Arg 
        115                 120                 125             


Ser Lys Gly Asp Ala Leu Asp Lys Cys Gln Ala Glu Leu Lys Lys Leu 
    130                 135                 140                 


Arg Lys Lys Ser Gln Gly Ser Lys Asn Pro Gln Lys Tyr Ser Asp Lys 
145                 150                 155                 160 


Glu Leu Gln Tyr Ile Asp Ala Ile Ser Asn Lys Gln Gly Glu Leu Glu 
                165                 170                 175     


Asn Tyr Val Ser Asp Gly Tyr Lys Xaa Ala Leu Xaa Glu Glu Arg Arg 
            180                 185                 190         


Arg Phe Cys Phe Leu Val Glu Lys Gln Cys Ala Val Ala Lys Asn Ser 
        195                 200                 205             


Ala Ala Tyr His Ser Lys Gly Lys Glu Leu Leu Ala Gln Lys Leu Pro 
    210                 215                 220                 


Leu Trp Gln Gln Ala Cys Ala Asp Pro Ser Lys Ile Pro Glu Arg Ala 
225                 230                 235                 240 


Val Gln Leu Met Gln Gln Val Ala Ser Asn Gly Ala Xaa Leu Pro Ser 
                245                 250                 255     


Ala Leu Ser Ala Ser Lys Ser Asn Leu Val Ile Ser Asp Pro Ile Pro 
            260                 265                 270         


Gly Ala Lys Pro Leu Pro Val Pro Pro Glu Leu Ala Pro Phe Val Gly 
        275                 280                 285             


Arg Met Ser Ala Gln Glu Ser Xaa Pro Ile Met Asn Gly Val Xaa Gly 
    290                 295                 300                 


Pro Asp Gly Glu Asp Tyr Ser Pro Trp Ala Asp Arg Lys Ala Ala Gln 
305                 310                 315                 320 


Pro Lys Ser Leu Ser Pro Pro Gln Ser Gln Ser Lys Leu Ser Asp Ser 
                325                 330                 335     


Tyr Ser Asn Xaa Leu Pro Val Arg Lys Ser Val Xaa Pro Lys Asn Ser 
            340                 345                 350         


Tyr Ala Xaa Xaa Glu Asn Lys Xaa Leu Pro Arg Ser Ser Ser Met Ala 
        355                 360                 365             


Ala Gly Leu Glu Arg Asn Gly Arg Met Arg Val Lys Ala Ile Phe Ser 
    370                 375                 380                 


His Ala Ala Gly Asp Asn Ser Xaa Leu Leu Ser Phe Lys Glu Gly Asp 
385                 390                 395                 400 


Leu Ile Xaa Leu Leu Val Pro Glu Ala Arg Asp Gly Trp His Tyr Gly 
                405                 410                 415     


Glu Ser Glu Lys Xaa Lys Met Arg Gly Trp Phe Pro Phe Ser Tyr Xaa 
            420                 425                 430         


Arg Val Leu Asp Ser Asp Gly Ser Asp Arg Leu His Met Ser Leu Gln 
        435                 440                 445             


Gln Gly Lys Ser Ser Ser Xaa Gly Asn Leu Leu Asp Lys Asp Asp Leu 
    450                 455                 460                 


Ala Ile Pro Pro Pro Asp Tyr Gly Ala Ala Ser Arg Ala Phe Pro Ala 
465                 470                 475                 480 


Gln Xaa Ala Ser Gly Phe Lys Gln Arg Pro Tyr Ser Val Ala Val Pro 
                485                 490                 495     


Ala Phe Ser Gln Gly Leu Asp Asp Tyr Gly Ala Arg Ser Met Ser Ser 
            500                 505                 510         


Ala Asp Val Glu Val Ala Arg Phe 
        515                 520 


<210> 3877
<211> 521
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<400> 3877
Met Ser Leu Ser Arg Ser Glu Glu Met His Arg Leu Xaa Glu Asn Val 
1               5                   10                  15      


Tyr Lys Xaa Ile Met Glu Gln Phe Asn Pro Ser Leu Arg Asn Phe Ile 
            20                  25                  30          


Ala Met Gly Lys Asn Tyr Glu Lys Ala Leu Ala Gly Val Xaa Tyr Ala 
        35                  40                  45              


Ala Lys Gly Tyr Phe Asp Ala Leu Val Lys Met Gly Glu Leu Ala Ser 
    50                  55                  60                  


Glu Ser Gln Gly Ser Lys Glu Leu Gly Asp Val Leu Phe Gln Met Ala 
65                  70                  75                  80  


Glu Val His Arg Gln Ile Gln Asn Gln Leu Glu Glu Met Leu Lys Ser 
                85                  90                  95      


Phe His Asn Glu Leu Leu Xaa Gln Leu Glu Gln Lys Val Glu Leu Asp 
            100                 105                 110         


Ser Arg Tyr Leu Ser Ala Ala Leu Lys Lys Tyr Gln Xaa Glu Gln Arg 
        115                 120                 125             


Ser Lys Gly Asp Ala Leu Asp Lys Cys Gln Ala Glu Leu Lys Lys Leu 
    130                 135                 140                 


Arg Lys Lys Ser Gln Gly Ser Lys Asn Pro Gln Lys Tyr Ser Asp Lys 
145                 150                 155                 160 


Glu Leu Gln Tyr Ile Asp Ala Ile Ser Asn Lys Gln Gly Glu Leu Glu 
                165                 170                 175     


Asn Tyr Val Ser Asp Gly Tyr Lys Xaa Ala Leu Xaa Glu Glu Arg Arg 
            180                 185                 190         


Arg Phe Cys Phe Leu Val Glu Lys Gln Cys Ala Val Ala Lys Asn Ser 
        195                 200                 205             


Ala Ala Tyr His Ser Lys Gly Lys Glu Leu Leu Ala Gln Lys Leu Pro 
    210                 215                 220                 


Leu Trp Gln Gln Ala Cys Ala Asp Pro Ser Lys Ile Pro Glu Arg Ala 
225                 230                 235                 240 


Val Gln Leu Met Gln Gln Val Ala Ser Asn Gly Ala Xaa Leu Pro Ser 
                245                 250                 255     


Ala Leu Ser Ala Ser Lys Ser Asn Leu Val Ile Ser Asp Pro Ile Pro 
            260                 265                 270         


Gly Ala Lys Pro Leu Pro Val Pro Pro Glu Leu Ala Pro Phe Val Gly 
        275                 280                 285             


Arg Met Ser Ala Gln Glu Ser Xaa Pro Ile Met Asn Gly Val Xaa Gly 
    290                 295                 300                 


Pro Asp Gly Glu Asp Tyr Ser Pro Trp Ala Asp Arg Lys Ala Ala Gln 
305                 310                 315                 320 


Pro Lys Ser Leu Ser Pro Pro Gln Ser Gln Ser Lys Leu Ser Asp Ser 
                325                 330                 335     


Tyr Ser Asn Xaa Leu Pro Val Arg Lys Ser Val Xaa Pro Lys Asn Ser 
            340                 345                 350         


Tyr Ala Xaa Xaa Glu Asn Lys Xaa Leu Pro Arg Ser Ser Ser Met Ala 
        355                 360                 365             


Ala Gly Leu Glu Arg Asn Gly Arg Met Arg Val Lys Ala Ile Phe Ser 
    370                 375                 380                 


His Ala Ala Gly Asp Asn Ser Xaa Leu Leu Ser Phe Lys Glu Gly Asp 
385                 390                 395                 400 


Leu Ile Xaa Leu Leu Val Pro Glu Ala Arg Asp Gly Trp His Tyr Gly 
                405                 410                 415     


Glu Ser Glu Lys Xaa Lys Met Arg Gly Trp Phe Pro Phe Ser Tyr Xaa 
            420                 425                 430         


Arg Val Leu Asp Ser Asp Gly Ser Asp Arg Leu His Met Ser Leu Gln 
        435                 440                 445             


Gln Gly Lys Ser Ser Ser Xaa Gly Asn Leu Leu Asp Lys Asp Asp Leu 
    450                 455                 460                 


Ala Ile Pro Pro Pro Asp Tyr Gly Ala Ala Ser Arg Ala Phe Pro Ala 
465                 470                 475                 480 


Gln Xaa Ala Ser Gly Phe Lys Gln Arg Pro Tyr Ser Val Ala Val Pro 
                485                 490                 495     


Ala Phe Ser Gln Gly Leu Asp Asp Tyr Gly Ala Arg Ser Met Ser Ser 
            500                 505                 510         


Gly Ser Gly Xaa Leu Val Ser Xaa Val 
        515                 520     


<210> 3878
<211> 534
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<400> 3878
Met Ser Leu Ser Arg Ser Glu Glu Met His Arg Leu Xaa Glu Asn Val 
1               5                   10                  15      


Tyr Lys Xaa Ile Met Glu Gln Phe Asn Pro Ser Leu Arg Asn Phe Ile 
            20                  25                  30          


Ala Met Gly Lys Asn Tyr Glu Lys Ala Leu Ala Gly Val Xaa Tyr Ala 
        35                  40                  45              


Ala Lys Gly Tyr Phe Asp Ala Leu Val Lys Met Gly Glu Leu Ala Ser 
    50                  55                  60                  


Glu Ser Gln Gly Ser Lys Glu Leu Gly Asp Val Leu Phe Gln Met Ala 
65                  70                  75                  80  


Glu Val His Arg Gln Ile Gln Asn Gln Leu Glu Glu Met Leu Lys Ser 
                85                  90                  95      


Phe His Asn Glu Leu Leu Xaa Gln Leu Glu Gln Lys Val Glu Leu Asp 
            100                 105                 110         


Ser Arg Tyr Leu Ser Ala Ala Leu Lys Lys Tyr Gln Xaa Glu Gln Arg 
        115                 120                 125             


Ser Lys Gly Asp Ala Leu Asp Lys Cys Gln Ala Glu Leu Lys Lys Leu 
    130                 135                 140                 


Arg Lys Lys Ser Gln Gly Ser Lys Asn Pro Gln Lys Tyr Ser Asp Lys 
145                 150                 155                 160 


Glu Leu Gln Tyr Ile Asp Ala Ile Ser Asn Lys Gln Gly Glu Leu Glu 
                165                 170                 175     


Asn Tyr Val Ser Asp Gly Tyr Lys Xaa Ala Leu Xaa Glu Glu Arg Arg 
            180                 185                 190         


Arg Phe Cys Phe Leu Val Glu Lys Gln Cys Ala Val Ala Lys Asn Ser 
        195                 200                 205             


Ala Ala Tyr His Ser Lys Gly Lys Glu Leu Leu Ala Gln Lys Leu Pro 
    210                 215                 220                 


Leu Trp Gln Gln Ala Cys Ala Asp Pro Ser Lys Ile Pro Glu Arg Ala 
225                 230                 235                 240 


Val Gln Leu Met Gln Gln Val Ala Ser Asn Gly Ala Xaa Leu Pro Ser 
                245                 250                 255     


Ala Leu Ser Ala Ser Lys Ser Asn Leu Val Ile Ser Asp Pro Ile Pro 
            260                 265                 270         


Gly Ala Lys Pro Leu Pro Val Pro Pro Glu Leu Ala Pro Phe Val Gly 
        275                 280                 285             


Arg Met Ser Ala Gln Glu Ser Xaa Pro Ile Met Asn Gly Val Xaa Gly 
    290                 295                 300                 


Pro Asp Gly Glu Asp Tyr Ser Pro Trp Ala Asp Arg Lys Ala Ala Gln 
305                 310                 315                 320 


Pro Lys Ser Leu Ser Pro Pro Gln Ser Gln Ser Lys Leu Ser Asp Ser 
                325                 330                 335     


Tyr Ser Asn Xaa Leu Pro Val Arg Lys Ser Val Xaa Pro Lys Asn Ser 
            340                 345                 350         


Tyr Ala Xaa Xaa Glu Asn Lys Xaa Leu Pro Arg Ser Ser Ser Met Ala 
        355                 360                 365             


Ala Gly Leu Glu Arg Asn Gly Arg Met Arg Val Lys Ala Ile Phe Ser 
    370                 375                 380                 


His Ala Ala Gly Asp Asn Ser Xaa Leu Leu Ser Phe Lys Glu Gly Asp 
385                 390                 395                 400 


Leu Ile Xaa Leu Leu Val Pro Glu Ala Arg Asp Gly Trp His Tyr Gly 
                405                 410                 415     


Glu Ser Glu Lys Xaa Lys Met Arg Gly Trp Phe Pro Phe Ser Tyr Xaa 
            420                 425                 430         


Arg Val Leu Asp Ser Asp Gly Ser Asp Arg Leu His Met Ser Leu Gln 
        435                 440                 445             


Gln Gly Lys Ser Ser Ser Xaa Gly Asn Leu Leu Asp Lys Asp Asp Leu 
    450                 455                 460                 


Ala Ile Pro Pro Pro Asp Tyr Gly Ala Ala Ser Arg Ala Phe Pro Ala 
465                 470                 475                 480 


Gln Xaa Ala Ser Gly Phe Lys Gln Arg Pro Tyr Ser Val Ala Val Pro 
                485                 490                 495     


Ala Phe Ser Gln Gly Leu Asp Asp Tyr Gly Ala Arg Ser Met Ser Arg 
            500                 505                 510         


Asn Pro Phe Ala His Val Gln Leu Lys Pro Xaa Val Xaa Asn Asp Arg 
        515                 520                 525             


Ser Ala Pro Leu Leu Ser 
    530                 


<210> 3879
<211> 552
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<400> 3879
Met Ser Leu Ser Arg Ser Glu Glu Met His Arg Leu Xaa Glu Asn Val 
1               5                   10                  15      


Tyr Lys Xaa Ile Met Glu Gln Phe Asn Pro Ser Leu Arg Asn Phe Ile 
            20                  25                  30          


Ala Met Gly Lys Asn Tyr Glu Lys Ala Leu Ala Gly Val Xaa Tyr Ala 
        35                  40                  45              


Ala Lys Gly Tyr Phe Asp Ala Leu Val Lys Met Gly Glu Leu Ala Ser 
    50                  55                  60                  


Glu Ser Gln Gly Ser Lys Glu Leu Gly Asp Val Leu Phe Gln Met Ala 
65                  70                  75                  80  


Glu Val His Arg Gln Ile Gln Asn Gln Leu Glu Glu Met Leu Lys Ser 
                85                  90                  95      


Phe His Asn Glu Leu Leu Xaa Gln Leu Glu Gln Lys Val Glu Leu Asp 
            100                 105                 110         


Ser Arg Tyr Leu Ser Ala Ala Leu Lys Lys Tyr Gln Xaa Glu Gln Arg 
        115                 120                 125             


Ser Lys Gly Asp Ala Leu Asp Lys Cys Gln Ala Glu Leu Lys Lys Leu 
    130                 135                 140                 


Arg Lys Lys Ser Gln Gly Ser Lys Asn Pro Gln Lys Tyr Ser Asp Lys 
145                 150                 155                 160 


Glu Leu Gln Tyr Ile Asp Ala Ile Ser Asn Lys Gln Gly Glu Leu Glu 
                165                 170                 175     


Asn Tyr Val Ser Asp Gly Tyr Lys Xaa Ala Leu Xaa Glu Glu Arg Arg 
            180                 185                 190         


Arg Phe Cys Phe Leu Val Glu Lys Gln Cys Ala Val Ala Lys Asn Ser 
        195                 200                 205             


Ala Ala Tyr His Ser Lys Gly Lys Glu Leu Leu Ala Gln Lys Leu Pro 
    210                 215                 220                 


Leu Trp Gln Gln Ala Cys Ala Asp Pro Ser Lys Ile Pro Glu Arg Ala 
225                 230                 235                 240 


Val Gln Leu Met Gln Gln Val Ala Ser Asn Gly Ala Xaa Leu Pro Ser 
                245                 250                 255     


Ala Leu Ser Ala Ser Lys Ser Asn Leu Val Ile Ser Asp Pro Ile Pro 
            260                 265                 270         


Gly Ala Lys Pro Leu Pro Val Pro Pro Glu Leu Ala Pro Phe Val Gly 
        275                 280                 285             


Arg Met Ser Ala Gln Glu Ser Xaa Pro Ile Met Asn Gly Val Xaa Gly 
    290                 295                 300                 


Pro Asp Gly Glu Asp Tyr Ser Pro Trp Ala Asp Arg Lys Ala Ala Gln 
305                 310                 315                 320 


Pro Lys Ser Leu Ser Pro Pro Gln Ser Gln Ser Lys Leu Ser Asp Ser 
                325                 330                 335     


Tyr Ser Asn Xaa Leu Pro Val Arg Lys Ser Val Xaa Pro Lys Asn Ser 
            340                 345                 350         


Tyr Ala Xaa Xaa Glu Asn Lys Xaa Leu Pro Arg Ser Ser Ser Met Ala 
        355                 360                 365             


Ala Gly Leu Glu Arg Asn Gly Arg Met Arg Val Lys Ala Ile Phe Ser 
    370                 375                 380                 


His Ala Ala Gly Asp Asn Ser Xaa Leu Leu Ser Phe Lys Glu Gly Asp 
385                 390                 395                 400 


Leu Ile Xaa Leu Leu Val Pro Glu Ala Arg Asp Gly Trp His Tyr Gly 
                405                 410                 415     


Glu Ser Glu Lys Xaa Lys Met Arg Gly Trp Phe Pro Phe Ser Tyr Xaa 
            420                 425                 430         


Arg Val Leu Asp Ser Asp Gly Ser Asp Arg Leu His Met Ser Leu Gln 
        435                 440                 445             


Gln Gly Lys Ser Ser Ser Xaa Gly Asn Leu Leu Asp Lys Asp Asp Leu 
    450                 455                 460                 


Ala Ile Pro Pro Pro Asp Tyr Gly Ala Ala Ser Arg Ala Phe Pro Ala 
465                 470                 475                 480 


Gln Xaa Ala Ser Gly Phe Lys Gln Arg Pro Tyr Ser Val Ala Val Pro 
                485                 490                 495     


Ala Phe Ser Gln Gly Leu Asp Asp Tyr Gly Ala Arg Ser Met Ser Arg 
            500                 505                 510         


Asn Pro Phe Ala His Val Gln Leu Lys Pro Xaa Val Xaa Asn Asp Arg 
        515                 520                 525             


Cys Asp Leu Ser Ala Gln Gly Pro Glu Gly Arg Glu His Gly Asp Gly 
    530                 535                 540                 


Ser Ala Arg Xaa Leu Ala Gly Arg 
545                 550         


<210> 3880
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<400> 3880
Met Ser Leu Ser Arg Ser Glu Glu Met His Arg Leu Xaa Glu Asn Val 
1               5                   10                  15      


Tyr Lys Xaa Ile Met Glu Gln Phe Asn Pro Ser Leu Arg Asn Phe Ile 
            20                  25                  30          


Ala Met Gly Lys Asn Tyr Glu Lys Ala Leu Ala Gly Val Xaa Tyr Ala 
        35                  40                  45              


Ala Lys Gly Tyr Phe Asp Ala Leu Val Lys Met Gly Glu Leu Ala Ser 
    50                  55                  60                  


Glu Ser Gln Gly Ser Lys Glu Leu Gly Asp Val Leu Phe Gln Met Ala 
65                  70                  75                  80  


Glu Val His Arg Gln Ile Gln Asn Gln Leu Glu Glu Met Pro Cys Pro 
                85                  90                  95      


Ala Ser Cys Ser Gly Ser Met Cys Trp Ser 
            100                 105     


<210> 3881
<211> 97
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<400> 3881
Gln Xaa Glu Gln Arg Ser Lys Gly Asp Ala Leu Asp Lys Cys Gln Ala 
1               5                   10                  15      


Glu Leu Lys Lys Leu Arg Lys Lys Ser Gln Gly Ser Lys Asn Pro Gln 
            20                  25                  30          


Lys Tyr Ser Asp Lys Glu Leu Gln Tyr Ile Asp Ala Ile Ser Asn Lys 
        35                  40                  45              


Gln Gly Glu Leu Glu Asn Tyr Val Ser Asp Gly Tyr Lys Xaa Ala Leu 
    50                  55                  60                  


Xaa Glu Glu Arg Arg Arg Phe Cys Phe Leu Val Glu Lys Gln Cys Ala 
65                  70                  75                  80  


Val Ala Lys Asn Ser Ala Ala Tyr His Ser Lys Gly Gly Pro Gly Pro 
                85                  90                  95      


Val 
    


<210> 3882
<211> 216
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<400> 3882
Xaa Pro Lys Ser Leu Ser Pro Pro Gln Ser Gln Ser Lys Leu Ser Asp 
1               5                   10                  15      


Ser Tyr Ser Asn Xaa Leu Pro Val Arg Lys Ser Val Xaa Pro Lys Asn 
            20                  25                  30          


Ser Tyr Ala Xaa Xaa Ala Glu Asn Lys Xaa Leu Pro Arg Ser Ser Ser 
        35                  40                  45              


Met Ala Ala Gly Leu Glu Arg Asn Gly Arg Met Arg Val Lys Ala Ile 
    50                  55                  60                  


Phe Ser His Ala Ala Gly Asp Asn Ser Xaa Leu Leu Ser Phe Lys Glu 
65                  70                  75                  80  


Gly Asp Leu Ile Xaa Leu Leu Val Pro Glu Ala Arg Asp Gly Trp His 
                85                  90                  95      


Tyr Gly Glu Ser Glu Lys Xaa Lys Met Arg Gly Trp Phe Pro Phe Ser 
            100                 105                 110         


Tyr Xaa Arg Val Leu Asp Ser Asp Gly Ser Asp Arg Leu His Met Ser 
        115                 120                 125             


Leu Gln Gln Gly Lys Ser Ser Ser Xaa Gly Asn Leu Leu Asp Lys Asp 
    130                 135                 140                 


Asp Leu Ala Ile Pro Pro Pro Asp Tyr Gly Ala Ala Ser Arg Ala Phe 
145                 150                 155                 160 


Pro Ala Gln Xaa Ala Ser Gly Phe Lys Gln Arg Pro Tyr Ser Val Ala 
                165                 170                 175     


Val Pro Ala Phe Ser Gln Gly Leu Asp Asp Tyr Gly Ala Arg Ser Met 
            180                 185                 190         


Ser Arg Asn Pro Phe Ala His Val Gln Leu Lys Pro Xaa Val Xaa Asn 
        195                 200                 205             


Asp Arg Ser Ala Pro Leu Leu Ser 
    210                 215     


<210> 3883
<211> 511
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<400> 3883
Met Ser Arg Gly Pro Glu Glu Val Asn Arg Leu Xaa Glu Ser Xaa Tyr 
1               5                   10                  15      


Arg Asn Val Met Glu Gln Phe Asn Pro Gly Leu Arg Asn Leu Ile Asn 
            20                  25                  30          


Leu Gly Lys Asn Tyr Glu Lys Ala Val Asn Ala Met Ile Leu Ala Gly 
        35                  40                  45              


Lys Ala Tyr Tyr Asp Gly Val Ala Lys Ile Gly Glu Ile Ala Xaa Gly 
    50                  55                  60                  


Ser Pro Val Ser Xaa Glu Leu Gly His Val Leu Ile Glu Ile Ser Ser 
65                  70                  75                  80  


Xaa His Lys Lys Leu Asn Glu Ser Leu Asp Glu Asn Phe Lys Lys Phe 
                85                  90                  95      


His Lys Glu Ile Ile His Glu Leu Glu Lys Lys Ile Glu Leu Asp Val 
            100                 105                 110         


Lys Tyr Met Asn Ala Xaa Leu Lys Arg Tyr Gln Xaa Glu His Lys Asn 
        115                 120                 125             


Lys Leu Glu Ser Leu Glu Lys Ser Gln Ala Glu Leu Lys Lys Ile Arg 
    130                 135                 140                 


Arg Lys Ser Gln Gly Ser Arg Asn Ala Leu Lys Tyr Glu His Lys Glu 
145                 150                 155                 160 


Ile Glu Tyr Val Glu Xaa Val Xaa Ser Arg Gln Ser Glu Ile Gln Lys 
                165                 170                 175     


Phe Ile Ala Asp Gly Cys Lys Glu Ala Leu Leu Glu Glu Lys Arg Arg 
            180                 185                 190         


Phe Cys Phe Leu Val Asp Lys His Cys Gly Phe Ala Asn His Ile His 
        195                 200                 205             


Tyr Tyr His Leu Gln Ser Ala Glu Leu Leu Asn Ser Lys Leu Pro Arg 
    210                 215                 220                 


Trp Gln Glu Xaa Cys Val Asp Ala Ile Lys Val Pro Glu Lys Ile Met 
225                 230                 235                 240 


Asn Met Ile Glu Glu Ile Lys Xaa Pro Ala Ser Xaa Pro Val Ser Gly 
                245                 250                 255     


Xaa Pro Gln Ala Ser Pro Met Ile Glu Arg Ser Asn Val Val Arg Lys 
            260                 265                 270         


Asp Tyr Asp Xaa Leu Ser Lys Cys Ser Pro Lys Met Pro Pro Ala Pro 
        275                 280                 285             


Ser Gly Arg Ala Tyr Xaa Ser Pro Leu Ile Asp Met Phe Asn Asn Pro 
    290                 295                 300                 


Ala Xaa Ala Ala Pro Asn Ser Gln Arg Val Asn Asn Ser Xaa Gly Xaa 
305                 310                 315                 320 


Ser Glu Asp Pro Ser Leu Gln Arg Ser Val Ser Val Ala Xaa Gly Leu 
                325                 330                 335     


Asn Met Met Lys Lys Gln Lys Val Lys Xaa Ile Phe Pro His Xaa Ala 
            340                 345                 350         


Gly Ser Asn Lys Xaa Leu Leu Ser Phe Ala Gln Gly Asp Val Ile Xaa 
        355                 360                 365             


Leu Leu Ile Pro Glu Glu Lys Asp Gly Trp Leu Tyr Gly Glu His Asp 
    370                 375                 380                 


Val Ser Lys Ala Arg Gly Trp Phe Pro Ser Ser Tyr Xaa Lys Leu Leu 
385                 390                 395                 400 


Glu Glu Asn Glu Xaa Glu Ala Val Xaa Val Pro Xaa Pro Ser Pro Xaa 
                405                 410                 415     


Pro Val Arg Ser Ile Ser Xaa Val Asn Leu Ser Glu Asn Ser Ser Val 
            420                 425                 430         


Val Ile Pro Pro Pro Asp Tyr Leu Glu Cys Leu Ser Met Gly Ala Ala 
        435                 440                 445             


Ala Asp Arg Arg Ala Asp Ser Ala Arg Xaa Xaa Ser Xaa Phe Lys Ala 
    450                 455                 460                 


Pro Ala Ser Lys Pro Glu Xaa Ala Ala Pro Asn Asp Ala Asn Gly Xaa 
465                 470                 475                 480 


Ala Lys Pro Pro Phe Leu Ser Gly Glu Asn Pro Phe Ala Xaa Val Lys 
                485                 490                 495     


Leu Arg Pro Xaa Val Xaa Asn Asp Arg Ser Ala Pro Ile Ile Arg 
            500                 505                 510     


<210> 3884
<211> 515
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<400> 3884
Met Ala Pro Glu Met Asp Gln Phe Tyr Arg Ser Xaa Met Ala Ile Tyr 
1               5                   10                  15      


Lys Ser Ile Met Glu Gln Phe Asn Pro Ala Leu Glu Asn Leu Val Tyr 
            20                  25                  30          


Leu Gly Asn Asn Tyr Leu Arg Ala Phe His Ala Leu Ser Glu Ala Ala 
        35                  40                  45              


Glu Val Tyr Phe Ser Ala Ile Gln Lys Ile Gly Glu Arg Ala Leu Gln 
    50                  55                  60                  


Ser Pro Xaa Ser Gln Ile Leu Gly Glu Ile Leu Val Gln Met Ser Asp 
65                  70                  75                  80  


Xaa Gln Arg His Leu Asn Ser Asp Leu Glu Val Val Val Gln Xaa Phe 
                85                  90                  95      


His Gly Gly Leu Leu Gln His Met Glu Lys Asn Xaa Lys Leu Asp Met 
            100                 105                 110         


Gln Phe Ile Lys Asp Ser Arg Gln His Tyr Glu Leu Glu Tyr Arg His 
        115                 120                 125             


Arg Ala Ala Asn Leu Glu Lys Cys Met Ser Glu Leu Trp Arg Met Glu 
    130                 135                 140                 


Arg Lys Arg Asp Lys Asn Val Arg Glu Met Lys Glu Ser Val Asn Arg 
145                 150                 155                 160 


Leu His Ala Gln Met Gln Ala Phe Val Ser Glu Ser Gln Arg Ala Ala 
                165                 170                 175     


Glu Leu Glu Glu Lys Arg Arg Tyr Arg Phe Leu Ala Glu Lys His Leu 
            180                 185                 190         


Leu Leu Ser Asn Xaa Phe Leu Gln Phe Phe Gly Arg Ala Arg Gly Met 
        195                 200                 205             


Leu Gln Asn Arg Val Leu Leu Trp Lys Glu Gln Ser Glu Ala Ser Arg 
    210                 215                 220                 


Ser Pro Ser Arg Ala His Ser Pro Gly Leu Leu Gly Pro Ala Leu Gly 
225                 230                 235                 240 


Pro Pro Tyr Pro Ser Gly Arg Leu Xaa Pro Xaa Cys Leu Asp Met Pro 
                245                 250                 255     


Pro Arg Pro Leu Gly Glu Phe Ser Ser Pro Arg Ser Arg His Gly Ser 
            260                 265                 270         


Gly Ser Tyr Gly Xaa Glu Pro Asp Ala Arg Pro Ala Ser Gln Leu Glu 
        275                 280                 285             


Pro Asp Arg Arg Ser Leu Pro Arg Xaa Pro Ser Ala Ser Ser Leu Tyr 
    290                 295                 300                 


Ser Gly Ser Ala Gln Ser Ser Arg Ser Asn Ser Phe Gly Glu Arg Pro 
305                 310                 315                 320 


Gly Gly Gly Gly Gly Ala Arg Arg Val Arg Ala Leu Val Ser His Ser 
                325                 330                 335     


Glu Gly Ala Asn His Xaa Leu Leu Arg Phe Ser Ala Gly Asp Val Val 
            340                 345                 350         


Glu Val Leu Val Pro Glu Ala Gln Asn Gly Trp Leu Tyr Gly Lys Leu 
        355                 360                 365             


Glu Gly Ser Ser Ala Ser Gly Trp Phe Pro Glu Ala Tyr Val Lys Ala 
    370                 375                 380                 


Leu Glu Glu Gly Pro Val Asn Pro Met Xaa Pro Val Xaa Pro Met Xaa 
385                 390                 395                 400 


Ser Met Xaa Ser Met Ser Pro Met Xaa Pro Met Asn Pro Gly Asn Glu 
                405                 410                 415     


Leu Pro Ser Arg Ser Tyr Pro Leu Arg Gly Ser His Ser Leu Asp Asp 
            420                 425                 430         


Leu Leu Asp Arg Pro Gly Asn Ser Xaa Pro Ser Arg Val Pro Ser Arg 
        435                 440                 445             


Ala Pro Ser Pro Ala Pro Pro Pro Leu Pro Ser Ser Arg Arg Ser Ser 
    450                 455                 460                 


Met Gly Ser Xaa Ala Val Ala Xaa Asp Val Lys Lys Leu Met Ser Ser 
465                 470                 475                 480 


Glu Gln Tyr Pro Pro Gln Glu Leu Phe Pro Arg Gly Xaa Asn Pro Phe 
                485                 490                 495     


Ala Xaa Val Lys Leu Arg Pro Xaa Ile Xaa Asn Asp Arg Ser Ala Pro 
            500                 505                 510         


Leu Ile Arg 
        515 


<210> 3885
<211> 529
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<400> 3885
Met Ala Pro Glu Met Asp Gln Phe Tyr Arg Ser Xaa Met Ala Ile Tyr 
1               5                   10                  15      


Lys Ser Ile Met Glu Gln Phe Asn Pro Ala Leu Glu Asn Leu Val Tyr 
            20                  25                  30          


Leu Gly Asn Asn Tyr Leu Arg Ala Phe His Ala Leu Ser Glu Ala Ala 
        35                  40                  45              


Glu Val Tyr Phe Ser Ala Ile Gln Lys Ile Gly Glu Arg Ala Leu Gln 
    50                  55                  60                  


Ser Pro Xaa Ser Gln Ile Leu Gly Glu Ile Leu Val Gln Met Ser Asp 
65                  70                  75                  80  


Xaa Gln Arg His Leu Asn Ser Asp Leu Glu Val Val Val Gln Xaa Phe 
                85                  90                  95      


His Gly Gly Leu Leu Gln His Met Glu Lys Asn Xaa Lys Leu Asp Met 
            100                 105                 110         


Gln Phe Ile Lys Asp Ser Arg Gln His Tyr Glu Leu Glu Tyr Arg His 
        115                 120                 125             


Arg Ala Ala Asn Leu Glu Lys Cys Met Ser Glu Leu Trp Arg Met Glu 
    130                 135                 140                 


Arg Lys Arg Asp Lys Asn Val Arg Glu Met Lys Glu Ser Val Asn Arg 
145                 150                 155                 160 


Leu His Ala Gln Met Gln Ala Phe Val Ser Glu Ser Gln Arg Ala Ala 
                165                 170                 175     


Glu Leu Glu Glu Lys Arg Arg Tyr Arg Phe Leu Ala Glu Lys His Leu 
            180                 185                 190         


Leu Leu Ser Asn Xaa Phe Leu Gln Phe Phe Gly Arg Ala Arg Gly Met 
        195                 200                 205             


Leu Gln Asn Arg Val Leu Leu Trp Lys Glu Gln Ser Glu Ala Ser Arg 
    210                 215                 220                 


Ser Pro Ser Arg Ala His Ser Pro Gly Leu Leu Gly Pro Ala Leu Gly 
225                 230                 235                 240 


Pro Pro Tyr Pro Ser Gly Arg Leu Xaa Pro Xaa Cys Leu Asp Met Pro 
                245                 250                 255     


Pro Arg Pro Leu Gly Glu Phe Ser Ser Pro Arg Ser Arg His Gly Ser 
            260                 265                 270         


Gly Ser Tyr Gly Xaa Glu Pro Asp Ala Arg Pro Ala Ser Gln Leu Glu 
        275                 280                 285             


Pro Asp Arg Arg Ser Leu Pro Arg Xaa Pro Ser Ala Ser Ser Leu Tyr 
    290                 295                 300                 


Ser Gly Ser Ala Gln Ser Ser Arg Ser Asn Ser Phe Gly Glu Arg Pro 
305                 310                 315                 320 


Gly Gly Gly Gly Gly Ala Arg Arg Val Arg Ala Leu Val Ser His Ser 
                325                 330                 335     


Glu Gly Ala Asn His Xaa Leu Leu Arg Phe Ser Ala Gly Asp Val Val 
            340                 345                 350         


Glu Val Leu Val Pro Glu Ala Gln Asn Gly Trp Leu Tyr Gly Lys Leu 
        355                 360                 365             


Glu Gly Ser Ser Ala Ser Gly Trp Phe Pro Glu Ala Tyr Val Lys Ala 
    370                 375                 380                 


Leu Glu Glu Gly Pro Val Asn Pro Met Xaa Pro Val Xaa Pro Met Xaa 
385                 390                 395                 400 


Ser Met Xaa Ser Met Ser Pro Met Xaa Pro Met Asn Pro Gly Asn Glu 
                405                 410                 415     


Leu Pro Ser Arg Ser Tyr Pro Leu Arg Gly Ser His Ser Leu Asp Asp 
            420                 425                 430         


Leu Leu Asp Arg Pro Gly Asn Ser Ile Ala Pro Ser Glu Tyr Trp Asp 
        435                 440                 445             


Gly Gln Ser Arg Ser Arg Xaa Pro Ser Arg Val Pro Ser Arg Ala Pro 
    450                 455                 460                 


Ser Pro Ala Pro Pro Pro Leu Pro Ser Ser Arg Arg Ser Ser Met Gly 
465                 470                 475                 480 


Ser Xaa Ala Val Ala Xaa Asp Val Lys Lys Leu Met Ser Ser Glu Gln 
                485                 490                 495     


Tyr Pro Pro Gln Glu Leu Phe Pro Arg Gly Xaa Asn Pro Phe Ala Xaa 
            500                 505                 510         


Val Lys Leu Arg Pro Xaa Ile Xaa Asn Asp Arg Ser Ala Pro Leu Ile 
        515                 520                 525             


Arg 
    


<210> 3886
<211> 196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<400> 3886
Ser Ser Arg Ser Asn Ser Phe Gly Glu Arg Pro Gly Gly Gly Gly Gly 
1               5                   10                  15      


Ala Arg Arg Val Arg Ala Leu Val Ser His Ser Glu Gly Ala Asn His 
            20                  25                  30          


Xaa Leu Leu Arg Phe Ser Ala Gly Asp Val Val Glu Val Leu Val Pro 
        35                  40                  45              


Glu Ala Gln Asn Gly Trp Leu Tyr Gly Lys Leu Glu Gly Ser Ser Ala 
    50                  55                  60                  


Ser Gly Trp Phe Pro Glu Ala Tyr Val Lys Ala Leu Glu Glu Gly Pro 
65                  70                  75                  80  


Val Asn Pro Met Xaa Pro Val Xaa Pro Met Xaa Ser Met Xaa Ser Met 
                85                  90                  95      


Ser Pro Met Xaa Pro Met Asn Pro Gly Asn Glu Leu Pro Ser Arg Ser 
            100                 105                 110         


Tyr Pro Leu Arg Gly Ser His Ser Leu Asp Asp Leu Leu Asp Arg Pro 
        115                 120                 125             


Gly Asn Ser Ile Ala Pro Ser Glu Tyr Trp Asp Gly Gln Ser Arg Ser 
    130                 135                 140                 


Arg Xaa Pro Ser Arg Val Pro Ser Arg Ala Pro Ser Pro Ala Pro Pro 
145                 150                 155                 160 


Pro Leu Pro Ser Ser Arg Arg Ser Ser Met Gly Ser Xaa Ala Val Ala 
                165                 170                 175     


Xaa Asp Val Lys Gly His Lys Ser Phe Cys His Cys Gln Ala Ser Ser 
            180                 185                 190         


His His His Gln 
        195     


<210> 3887
<211> 1187
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1165)
<223> Selenocysteine

<400> 3887
Met Arg Pro Arg Gly Ala Ala Phe Ala Ala Gly Pro Pro Gly Asp Leu 
1               5                   10                  15      


His Leu Gly Xaa Ala Ile Gly Phe Ala Gly Ala Ile Trp Arg Ser Arg 
            20                  25                  30          


Ser Pro Ala Met Ser Xaa Leu Leu Asp Ile Lys Ser Ser Val Leu Arg 
        35                  40                  45              


Gln Val Gln Val Cys Pro Ser Phe Arg Arg Arg Xaa Glu Gln Asp Pro 
    50                  55                  60                  


Gly Ser Ala Ser Ala Asp Pro Gln Glu Pro Ala Xaa Gly Ala Trp Lys 
65                  70                  75                  80  


Pro Gly Asp Gly Val Glu Phe Phe Ala His Met Arg Leu Met Leu Lys 
                85                  90                  95      


Lys Gly Glu Gly Arg Gln Gly Leu Pro Cys Leu Glu Val Pro Leu Arg 
            100                 105                 110         


Ser Gly Ser Pro Ala Pro Pro Glu Pro Val Asp Pro Ser Leu Gly Leu 
        115                 120                 125             


Arg Ala Leu Ala Pro Glu Glu Val Glu Met Leu Tyr Glu Glu Ala Leu 
    130                 135                 140                 


Tyr Xaa Val Leu Tyr Arg Ala Gly Xaa Met Gly Pro Asp Gln Val Asp 
145                 150                 155                 160 


Asp Glu Glu Ala Leu Leu Ser Tyr Leu Gln Gln Val Phe Gly Xaa Ser 
                165                 170                 175     


Leu Glu Glu His Xaa Glu Ala Ile Glu Arg Val Arg Lys Ala Lys Ala 
            180                 185                 190         


Pro Xaa Tyr Ala Leu Lys Val Ser Val Met Arg Ala Lys Asn Leu Leu 
        195                 200                 205             


Ala Lys Asp Pro Asn Gly Phe Ser Asp Pro Tyr Cys Met Leu Gly Ile 
    210                 215                 220                 


Leu Pro Ala Ser Asp Ala Xaa Arg Glu Pro Arg Ala Gln Lys Glu Gln 
225                 230                 235                 240 


Arg Phe Gly Phe Arg Lys Gly Ser Lys Arg Gly Gly Pro Leu Pro Ala 
                245                 250                 255     


Lys Cys Ile Gln Val Xaa Glu Val Lys Ser Ser Xaa Leu Asn Pro Val 
            260                 265                 270         


Trp Lys Glu His Phe Leu Phe Glu Ile Glu Asp Val Ser Xaa Asp Gln 
        275                 280                 285             


Leu His Leu Asp Ile Trp Asp His Asp Asp Asp Val Ser Leu Val Glu 
    290                 295                 300                 


Ala Cys Arg Lys Leu Asn Glu Val Ile Gly Leu Lys Gly Met Gly Arg 
305                 310                 315                 320 


Tyr Phe Lys Gln Ile Val Lys Ser Ala Arg Ala Asn Gly Xaa Ala Gly 
                325                 330                 335     


Pro Xaa Glu Asp His Xaa Asp Asp Phe Leu Gly Cys Leu Asn Ile Pro 
            340                 345                 350         


Val Arg Glu Val Pro Val Ala Gly Val Asp Arg Trp Phe Lys Leu Glu 
        355                 360                 365             


Pro Arg Ser Ser Ala Ser Arg Val Gln Gly His Cys His Leu Val Leu 
    370                 375                 380                 


Lys Leu Ile Xaa Xaa Gln Arg Asp Xaa Ala Met Ser Gln Arg Gly Arg 
385                 390                 395                 400 


Ser Gly Phe Leu Ser His Leu Leu Leu Leu Ser His Leu Leu Arg Leu 
                405                 410                 415     


Glu His Ser Ala Glu Glu Pro Asn Ser Ser Ser Trp Arg Gly Glu Leu 
            420                 425                 430         


Ser Xaa Pro Ala Ala Xaa Ile Leu Cys Leu His Gly Ala Gln Ser Asn 
        435                 440                 445             


Leu Ser Pro Leu Gln Leu Ala Val Leu His Trp Gln Val Ser Ser Arg 
    450                 455                 460                 


His His Gln Xaa Cys Xaa Leu Asp Tyr Ser Tyr Leu Leu Gly Leu Leu 
465                 470                 475                 480 


Glu Asp Met Gln Ala His Trp Glu Glu Ala Pro Ser Leu Pro Gln Glu 
                485                 490                 495     


Gln Glu Glu Ser Leu Ala Asp Ser Leu Ser Ala Phe Ser Glu Phe Gly 
            500                 505                 510         


Leu Gln Leu Leu Arg Gln Leu Arg Asp Tyr Phe Pro Ala Xaa Asn Ser 
        515                 520                 525             


Xaa Ala Val His Arg Leu Glu Leu Leu Leu Lys Cys Leu Gly Lys Leu 
    530                 535                 540                 


Gln Leu Phe Gln Pro Ser Phe Glu Ile Cys Pro Phe Glu Ser Glu Leu 
545                 550                 555                 560 


Asn Met Asp Ile Ala Ala Ala Leu Lys Arg Gly Asn Arg Glu Trp Tyr 
                565                 570                 575     


Asp Arg Ile Leu Asn Asp Lys Ser Pro Arg Glu Gln Pro Gly Pro Gln 
            580                 585                 590         


Arg Leu Pro Gly Leu Val Val Leu Ala Asp Ala Val Tyr Asp Asp Leu 
        595                 600                 605             


Gln Phe Cys Tyr Ser Val Tyr Ala Ser Leu Phe His Ser Ile Leu Asn 
    610                 615                 620                 


Val Asp Val Phe Xaa Leu Xaa Phe Arg Gln Leu Glu Arg Leu Val Ala 
625                 630                 635                 640 


Glu Glu Ala Trp Val Leu Xaa Glu Glu Leu Ser Pro Lys Met Xaa Leu 
                645                 650                 655     


Glu Val Ala Ser Gly Leu Phe Glu Leu Tyr Leu Xaa Leu Ala Asp Leu 
            660                 665                 670         


Gln Arg Phe Trp Asp Ser Ile Pro Gly Arg Asp Ser Arg Ser Leu Ala 
        675                 680                 685             


Leu Ala Gly Ile His Ala Pro Phe Leu Pro Ala Val Lys Leu Trp Phe 
    690                 695                 700                 


Gln Val Leu Arg Asp Gln Ala Lys Trp Arg Leu Gln Gly Ala Val Asp 
705                 710                 715                 720 


Met Asp Xaa Leu Glu Pro Val Asp Ala Ser Ser Arg His Ser Ser Ser 
                725                 730                 735     


Ala Ala Xaa Ala Gly Leu Cys Leu Ser His Ile Gln Glu Leu Trp Val 
            740                 745                 750         


Arg Leu Ala Trp Pro Asp Pro Ala Gln Ala Gln Gly Leu Gly Xaa Gln 
        755                 760                 765             


Leu Gly Gln Asp Val Cys Glu Ala Xaa Leu Phe Tyr Xaa Glu Leu Leu 
    770                 775                 780                 


Arg Lys Lys Val Asp Xaa Gln Pro Gly Ala Ala Gly Glu Ala Val Ser 
785                 790                 795                 800 


Glu Ala Leu Cys Val Val Leu Asn Asn Val Glu Leu Val Arg Lys Ala 
                805                 810                 815     


Ala Gly Gln Ala Leu Lys Gly Leu Ala Trp Pro Glu Gly Ala Xaa Gly 
            820                 825                 830         


Pro Glu Gly Val Leu Pro Arg Pro Leu Leu Ser Cys Xaa Gln Ala Leu 
        835                 840                 845             


Asp Asp Asp Leu Gln Arg Glu Ala His Xaa Val Xaa Ala His Leu Xaa 
    850                 855                 860                 


Ser Lys Met Val Gly Asp Ile Arg Lys Tyr Val Gln His Ile Ser Leu 
865                 870                 875                 880 


Ser Pro Asp Ser Ile Gln Asn Asp Glu Ala Val Ala Pro Leu Met Lys 
                885                 890                 895     


Tyr Leu Asp Glu Lys Leu Ala Leu Leu Asn Ala Ser Leu Val Lys Gly 
            900                 905                 910         


Asn Leu Ser Arg Val Leu Glu Ala Leu Trp Glu Leu Leu Leu Gln Ala 
        915                 920                 925             


Ile Leu Gln Ala Leu Gly Ala Asn Arg Asp Val Ser Ala Asp Phe Tyr 
    930                 935                 940                 


Ser Arg Phe His Phe Xaa Leu Glu Ala Leu Val Ser Phe Phe His Ala 
945                 950                 955                 960 


Glu Gly Gln Gly Leu Pro Leu Glu Ser Leu Arg Asp Gly Ser Tyr Lys 
                965                 970                 975     


Arg Leu Lys Glu Glu Leu Arg Leu His Lys Cys Ser Xaa Arg Glu Cys 
            980                 985                 990         


Ile Glu Gln Phe Tyr Leu Asp Lys  Leu Lys Gln Arg Xaa  Leu Glu Gln 
        995                 1000                 1005             


Asn Arg  Phe Gly Arg Leu Ser  Val Arg Cys His Tyr  Glu Ala Ala 
    1010                 1015                 1020             


Glu Gln  Arg Leu Ala Val Glu  Val Leu His Ala Ala  Asp Leu Leu 
    1025                 1030                 1035             


Pro Leu  Asp Ala Asn Gly Leu  Ser Asp Pro Phe Val  Ile Val Glu 
    1040                 1045                 1050             


Leu Gly  Pro Pro His Leu Phe  Pro Leu Val Arg Ser  Gln Arg Xaa 
    1055                 1060                 1065             


Gln Val  Lys Xaa Arg Xaa Leu  His Pro Val Tyr Asp  Glu Leu Phe 
    1070                 1075                 1080             


Tyr Phe  Ser Val Pro Ala Glu  Ala Cys Arg Arg Arg  Ala Ala Cys 
    1085                 1090                 1095             


Val Leu  Phe Xaa Val Met Asp  His Asp Trp Leu Ser  Xaa Asn Asp 
    1100                 1105                 1110             


Phe Ala  Gly Glu Ala Ala Leu  Gly Leu Gly Gly Val  Xaa Gly Val 
    1115                 1120                 1125             


Ala Arg  Pro Gln Val Gly Gly  Gly Ala Arg Ala Gly  Gln Pro Val 
    1130                 1135                 1140             


Xaa Leu  His Leu Cys Arg Pro  Arg Ala Gln Val Arg  Ser Ala Leu 
    1145                 1150                 1155             


Arg Arg  Leu Glu Gly Arg Xaa  Ser Lys Glu Ala Gln  Glu Phe Val 
    1160                 1165                 1170             


Lys Lys  Leu Lys Glu Leu Glu  Lys Cys Met Glu Ala  Asp Pro 
    1175                 1180                 1185         


<210> 3888
<211> 1169
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1093)..(1093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1108)..(1108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<400> 3888
Met Ser Xaa Leu Leu Asp Ile Lys Ser Ser Val Leu Arg Gln Val Gln 
1               5                   10                  15      


Val Cys Pro Ser Phe Arg Arg Arg Xaa Glu Gln Asp Pro Gly Ser Ala 
            20                  25                  30          


Ser Ala Asp Pro Gln Glu Pro Ala Xaa Gly Ala Trp Lys Pro Gly Asp 
        35                  40                  45              


Gly Val Glu Phe Phe Ala His Met Arg Leu Met Leu Lys Lys Gly Glu 
    50                  55                  60                  


Gly Arg Gln Gly Leu Pro Cys Leu Glu Ala Trp Gly Ser Pro Cys Arg 
65                  70                  75                  80  


Gln Ser Pro His Pro Gly Pro His Xaa Gln Val Pro Leu Arg Ser Gly 
                85                  90                  95      


Ser Pro Ala Pro Pro Glu Pro Val Asp Pro Ser Leu Gly Leu Arg Ala 
            100                 105                 110         


Leu Ala Pro Glu Glu Val Glu Met Leu Tyr Glu Glu Ala Leu Tyr Xaa 
        115                 120                 125             


Val Leu Tyr Arg Ala Gly Xaa Met Gly Pro Asp Gln Val Asp Asp Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ser Tyr Leu Gln Gln Val Phe Gly Xaa Ser Leu Glu 
145                 150                 155                 160 


Glu His Xaa Glu Ala Ile Glu Arg Val Arg Lys Ala Lys Ala Pro Xaa 
                165                 170                 175     


Tyr Ala Leu Lys Val Ser Val Met Arg Ala Lys Asn Leu Leu Ala Lys 
            180                 185                 190         


Asp Pro Asn Gly Phe Ser Asp Pro Tyr Cys Met Leu Gly Ile Leu Pro 
        195                 200                 205             


Ala Ser Asp Ala Xaa Arg Glu Pro Arg Ala Gln Lys Glu Gln Arg Phe 
    210                 215                 220                 


Gly Phe Arg Lys Gly Ser Lys Arg Gly Gly Pro Leu Pro Ala Lys Cys 
225                 230                 235                 240 


Ile Gln Val Xaa Glu Val Lys Ser Ser Xaa Leu Asn Pro Val Trp Lys 
                245                 250                 255     


Glu His Phe Leu Phe Glu Ile Glu Asp Val Ser Xaa Asp Gln Leu His 
            260                 265                 270         


Leu Asp Ile Trp Asp His Asp Asp Asp Val Ser Leu Val Glu Ala Cys 
        275                 280                 285             


Arg Lys Leu Asn Glu Val Ile Gly Leu Lys Gly Met Gly Arg Tyr Phe 
    290                 295                 300                 


Lys Gln Ile Val Lys Ser Ala Arg Ala Asn Gly Xaa Ala Gly Pro Xaa 
305                 310                 315                 320 


Glu Asp His Xaa Asp Asp Phe Leu Gly Cys Leu Asn Ile Pro Val Arg 
                325                 330                 335     


Glu Val Pro Val Ala Gly Val Asp Arg Trp Phe Lys Leu Glu Pro Arg 
            340                 345                 350         


Ser Ser Ala Ser Arg Val Gln Gly His Cys His Leu Val Leu Lys Leu 
        355                 360                 365             


Ile Xaa Xaa Gln Arg Asp Xaa Ala Met Ser Gln Arg Gly Arg Ser Gly 
    370                 375                 380                 


Phe Leu Ser His Leu Leu Leu Leu Ser His Leu Leu Arg Leu Glu His 
385                 390                 395                 400 


Ser Ala Glu Glu Pro Asn Ser Ser Ser Trp Arg Gly Glu Leu Ser Xaa 
                405                 410                 415     


Pro Ala Ala Xaa Ile Leu Cys Leu His Gly Ala Gln Ser Asn Leu Ser 
            420                 425                 430         


Pro Leu Gln Leu Ala Val Leu His Trp Gln Val Ser Ser Arg His His 
        435                 440                 445             


Gln Xaa Cys Xaa Leu Asp Tyr Ser Tyr Leu Leu Gly Leu Leu Glu Asp 
    450                 455                 460                 


Met Gln Ala His Trp Glu Glu Ala Pro Ser Leu Pro Gln Glu Gln Glu 
465                 470                 475                 480 


Glu Ser Leu Ala Asp Ser Leu Ser Ala Phe Ser Glu Phe Gly Leu Gln 
                485                 490                 495     


Leu Leu Arg Gln Leu Arg Asp Tyr Phe Pro Ala Xaa Asn Ser Xaa Ala 
            500                 505                 510         


Val His Arg Leu Glu Leu Leu Leu Lys Cys Leu Gly Lys Leu Gln Leu 
        515                 520                 525             


Phe Gln Pro Ser Phe Glu Ile Cys Pro Phe Glu Ser Glu Leu Asn Met 
    530                 535                 540                 


Asp Ile Ala Ala Ala Leu Lys Arg Gly Asn Arg Glu Trp Tyr Asp Arg 
545                 550                 555                 560 


Ile Leu Asn Asp Lys Ser Pro Arg Glu Gln Pro Gly Pro Gln Arg Leu 
                565                 570                 575     


Pro Gly Leu Val Val Leu Ala Asp Ala Val Tyr Asp Asp Leu Gln Phe 
            580                 585                 590         


Cys Tyr Ser Val Tyr Ala Ser Leu Phe His Ser Ile Leu Asn Val Asp 
        595                 600                 605             


Val Phe Xaa Leu Xaa Phe Arg Gln Leu Glu Arg Leu Val Ala Glu Glu 
    610                 615                 620                 


Ala Trp Val Leu Xaa Glu Glu Leu Ser Pro Lys Met Xaa Leu Glu Val 
625                 630                 635                 640 


Ala Ser Gly Leu Phe Glu Leu Tyr Leu Xaa Leu Ala Asp Leu Gln Arg 
                645                 650                 655     


Phe Trp Asp Ser Ile Pro Gly Arg Asp Ser Arg Ser Leu Ala Leu Ala 
            660                 665                 670         


Gly Ile His Ala Pro Phe Leu Pro Ala Val Lys Leu Trp Phe Gln Val 
        675                 680                 685             


Leu Arg Asp Gln Ala Lys Trp Arg Leu Gln Gly Ala Val Asp Met Asp 
    690                 695                 700                 


Xaa Leu Glu Pro Val Asp Ala Ser Ser Arg His Ser Ser Ser Ala Ala 
705                 710                 715                 720 


Xaa Ala Gly Leu Cys Leu Ser His Ile Gln Glu Leu Trp Val Arg Leu 
                725                 730                 735     


Ala Trp Pro Asp Pro Ala Gln Ala Gln Gly Leu Gly Xaa Gln Leu Gly 
            740                 745                 750         


Gln Asp Val Cys Glu Ala Xaa Leu Phe Tyr Xaa Glu Leu Leu Arg Lys 
        755                 760                 765             


Lys Val Asp Xaa Gln Pro Gly Ala Ala Gly Glu Ala Val Ser Glu Ala 
    770                 775                 780                 


Leu Cys Val Val Leu Asn Asn Val Glu Leu Val Arg Lys Ala Ala Gly 
785                 790                 795                 800 


Gln Ala Leu Lys Gly Leu Ala Trp Pro Glu Gly Ala Xaa Gly Pro Glu 
                805                 810                 815     


Gly Val Leu Pro Arg Pro Leu Leu Ser Cys Xaa Gln Ala Leu Asp Asp 
            820                 825                 830         


Asp Leu Gln Arg Glu Ala His Xaa Val Xaa Ala His Leu Xaa Ser Lys 
        835                 840                 845             


Met Val Gly Asp Ile Arg Lys Tyr Val Gln His Ile Ser Leu Ser Pro 
    850                 855                 860                 


Asp Ser Ile Gln Asn Asp Glu Ala Val Ala Pro Leu Met Lys Tyr Leu 
865                 870                 875                 880 


Asp Glu Lys Leu Ala Leu Leu Asn Ala Ser Leu Val Lys Gly Asn Leu 
                885                 890                 895     


Ser Arg Val Leu Glu Ala Leu Trp Glu Leu Leu Leu Gln Ala Ile Leu 
            900                 905                 910         


Gln Ala Leu Gly Ala Asn Arg Asp Val Ser Ala Asp Phe Tyr Ser Arg 
        915                 920                 925             


Phe His Phe Xaa Leu Glu Ala Leu Val Ser Phe Phe His Ala Glu Gly 
    930                 935                 940                 


Gln Gly Leu Pro Leu Glu Ser Leu Arg Asp Gly Ser Tyr Lys Arg Leu 
945                 950                 955                 960 


Lys Glu Glu Leu Arg Leu His Lys Cys Ser Xaa Arg Glu Cys Ile Glu 
                965                 970                 975     


Gln Phe Tyr Leu Asp Lys Leu Lys Gln Arg Xaa Leu Glu Gln Asn Arg 
            980                 985                 990         


Phe Gly Arg Leu Ser Val Arg Cys  His Tyr Glu Ala Ala  Glu Gln Arg 
        995                 1000                 1005             


Leu Ala  Val Glu Val Leu His  Ala Ala Asp Leu Leu  Pro Leu Asp 
    1010                 1015                 1020             


Ala Asn  Gly Leu Ser Asp Pro  Phe Val Ile Val Glu  Leu Gly Pro 
    1025                 1030                 1035             


Pro His  Leu Phe Pro Leu Val  Arg Ser Gln Arg Xaa  Gln Val Lys 
    1040                 1045                 1050             


Xaa Arg  Xaa Leu His Pro Val  Tyr Asp Glu Leu Phe  Tyr Phe Ser 
    1055                 1060                 1065             


Val Pro  Ala Glu Ala Cys Arg  Arg Arg Ala Ala Cys  Val Leu Phe 
    1070                 1075                 1080             


Xaa Val  Met Asp His Asp Trp  Leu Ser Xaa Asn Asp  Phe Ala Gly 
    1085                 1090                 1095             


Glu Ala  Ala Leu Gly Leu Gly  Gly Val Xaa Gly Val  Ala Arg Pro 
    1100                 1105                 1110             


Gln Val  Gly Gly Gly Ala Arg  Ala Gly Gln Pro Val  Xaa Leu His 
    1115                 1120                 1125             


Leu Cys  Arg Pro Arg Ala Gln  Val Arg Ser Ala Leu  Arg Arg Leu 
    1130                 1135                 1140             


Glu Gly  Arg Xaa Ser Lys Glu  Ala Gln Glu Phe Val  Lys Lys Leu 
    1145                 1150                 1155             


Lys Glu  Leu Glu Lys Cys Met  Glu Ala Asp Pro 
    1160                 1165                 


<210> 3889
<211> 1124
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<400> 3889
Met Ser Xaa Leu Leu Asp Ile Lys Ser Ser Val Leu Arg Gln Val Gln 
1               5                   10                  15      


Val Cys Pro Ser Phe Arg Arg Arg Xaa Glu Gln Asp Pro Gly Ser Ala 
            20                  25                  30          


Ser Ala Asp Pro Gln Glu Pro Ala Xaa Gly Ala Trp Lys Pro Gly Asp 
        35                  40                  45              


Gly Val Glu Phe Phe Ala His Met Arg Leu Met Leu Lys Lys Gly Glu 
    50                  55                  60                  


Gly Arg Gln Gly Leu Pro Cys Leu Glu Val Pro Leu Arg Ser Gly Ser 
65                  70                  75                  80  


Pro Ala Pro Pro Glu Pro Val Asp Pro Ser Leu Gly Leu Arg Ala Leu 
                85                  90                  95      


Ala Pro Glu Glu Ala Leu Leu Ser Tyr Leu Gln Gln Val Phe Gly Xaa 
            100                 105                 110         


Ser Leu Glu Glu His Xaa Glu Ala Ile Glu Arg Val Arg Lys Ala Lys 
        115                 120                 125             


Ala Pro Xaa Tyr Ala Leu Lys Val Ser Val Met Arg Ala Lys Asn Leu 
    130                 135                 140                 


Leu Ala Lys Asp Pro Asn Gly Phe Ser Asp Pro Tyr Cys Met Leu Gly 
145                 150                 155                 160 


Ile Leu Pro Ala Ser Asp Ala Xaa Arg Glu Pro Arg Ala Gln Lys Glu 
                165                 170                 175     


Gln Arg Phe Gly Phe Arg Lys Gly Ser Lys Arg Gly Gly Pro Leu Pro 
            180                 185                 190         


Ala Lys Cys Ile Gln Val Xaa Glu Val Lys Ser Ser Xaa Leu Asn Pro 
        195                 200                 205             


Val Trp Lys Glu His Phe Leu Phe Glu Ile Glu Asp Val Ser Xaa Asp 
    210                 215                 220                 


Gln Leu His Leu Asp Ile Trp Asp His Asp Asp Asp Val Ser Leu Val 
225                 230                 235                 240 


Glu Ala Cys Arg Lys Leu Asn Glu Val Ile Gly Leu Lys Gly Met Gly 
                245                 250                 255     


Arg Tyr Phe Lys Gln Ile Val Lys Ser Ala Arg Ala Asn Gly Xaa Ala 
            260                 265                 270         


Gly Pro Xaa Glu Asp His Xaa Asp Asp Phe Leu Gly Cys Leu Asn Ile 
        275                 280                 285             


Pro Val Arg Glu Val Pro Val Ala Gly Val Asp Arg Trp Phe Lys Leu 
    290                 295                 300                 


Glu Pro Arg Ser Ser Ala Ser Arg Val Gln Gly His Cys His Leu Val 
305                 310                 315                 320 


Leu Lys Leu Ile Xaa Xaa Gln Arg Asp Xaa Ala Met Ser Gln Arg Gly 
                325                 330                 335     


Arg Ser Gly Phe Leu Ser His Leu Leu Leu Leu Ser His Leu Leu Arg 
            340                 345                 350         


Leu Glu His Ser Ala Glu Glu Pro Asn Ser Ser Ser Trp Arg Gly Glu 
        355                 360                 365             


Leu Ser Xaa Pro Ala Ala Xaa Ile Leu Cys Leu His Gly Ala Gln Ser 
    370                 375                 380                 


Asn Leu Ser Pro Leu Gln Leu Ala Val Leu His Trp Gln Val Ser Ser 
385                 390                 395                 400 


Arg His His Gln Xaa Cys Xaa Leu Asp Tyr Ser Tyr Leu Leu Gly Leu 
                405                 410                 415     


Leu Glu Asp Met Gln Ala His Trp Glu Glu Ala Pro Ser Leu Pro Gln 
            420                 425                 430         


Glu Gln Glu Glu Ser Leu Ala Asp Ser Leu Ser Ala Phe Ser Glu Phe 
        435                 440                 445             


Gly Leu Gln Leu Leu Arg Gln Leu Arg Asp Tyr Phe Pro Ala Xaa Asn 
    450                 455                 460                 


Ser Xaa Ala Val His Arg Leu Glu Leu Leu Leu Lys Cys Leu Gly Lys 
465                 470                 475                 480 


Leu Gln Leu Phe Gln Pro Ser Phe Glu Ile Cys Pro Phe Glu Ser Glu 
                485                 490                 495     


Leu Asn Met Asp Ile Ala Ala Ala Leu Lys Arg Gly Asn Arg Glu Trp 
            500                 505                 510         


Tyr Asp Arg Ile Leu Asn Asp Lys Ser Pro Arg Glu Gln Pro Gly Pro 
        515                 520                 525             


Gln Arg Leu Pro Gly Leu Val Val Leu Ala Asp Ala Val Tyr Asp Asp 
    530                 535                 540                 


Leu Gln Phe Cys Tyr Ser Val Tyr Ala Ser Leu Phe His Ser Ile Leu 
545                 550                 555                 560 


Asn Val Asp Val Phe Xaa Leu Xaa Phe Arg Gln Leu Glu Arg Leu Val 
                565                 570                 575     


Ala Glu Glu Ala Trp Val Leu Xaa Glu Glu Leu Ser Pro Lys Met Xaa 
            580                 585                 590         


Leu Glu Val Ala Ser Gly Leu Phe Glu Leu Tyr Leu Xaa Leu Ala Asp 
        595                 600                 605             


Leu Gln Arg Phe Trp Asp Ser Ile Pro Gly Arg Asp Ser Arg Ser Leu 
    610                 615                 620                 


Ala Leu Ala Gly Ile His Ala Pro Phe Leu Pro Ala Val Lys Leu Trp 
625                 630                 635                 640 


Phe Gln Val Leu Arg Asp Gln Ala Lys Trp Arg Leu Gln Gly Ala Val 
                645                 650                 655     


Asp Met Asp Xaa Leu Glu Pro Val Asp Ala Ser Ser Arg His Ser Ser 
            660                 665                 670         


Ser Ala Ala Xaa Ala Gly Leu Cys Leu Ser His Ile Gln Glu Leu Trp 
        675                 680                 685             


Val Arg Leu Ala Trp Pro Asp Pro Ala Gln Ala Gln Gly Leu Gly Xaa 
    690                 695                 700                 


Gln Leu Gly Gln Asp Val Cys Glu Ala Xaa Leu Phe Tyr Xaa Glu Leu 
705                 710                 715                 720 


Leu Arg Lys Lys Val Asp Xaa Gln Pro Gly Ala Ala Gly Glu Ala Val 
                725                 730                 735     


Ser Glu Ala Leu Cys Val Val Leu Asn Asn Val Glu Leu Val Arg Lys 
            740                 745                 750         


Ala Ala Gly Gln Ala Leu Lys Gly Leu Ala Trp Pro Glu Gly Ala Xaa 
        755                 760                 765             


Gly Pro Glu Gly Val Leu Pro Arg Pro Leu Leu Ser Cys Xaa Gln Ala 
    770                 775                 780                 


Leu Asp Asp Asp Leu Gln Arg Glu Ala His Xaa Val Xaa Ala His Leu 
785                 790                 795                 800 


Xaa Ser Lys Met Val Gly Asp Ile Arg Lys Tyr Val Gln His Ile Ser 
                805                 810                 815     


Leu Ser Pro Asp Ser Ile Gln Asn Asp Glu Ala Val Ala Pro Leu Met 
            820                 825                 830         


Lys Tyr Leu Asp Glu Lys Leu Ala Leu Leu Asn Ala Ser Leu Val Lys 
        835                 840                 845             


Gly Asn Leu Ser Arg Val Leu Glu Ala Leu Trp Glu Leu Leu Leu Gln 
    850                 855                 860                 


Ala Ile Leu Gln Ala Leu Gly Ala Asn Arg Asp Val Ser Ala Asp Phe 
865                 870                 875                 880 


Tyr Ser Arg Phe His Phe Xaa Leu Glu Ala Leu Val Ser Phe Phe His 
                885                 890                 895     


Ala Glu Gly Gln Gly Leu Pro Leu Glu Ser Leu Arg Asp Gly Ser Tyr 
            900                 905                 910         


Lys Arg Leu Lys Glu Glu Leu Arg Leu His Lys Cys Ser Xaa Arg Glu 
        915                 920                 925             


Cys Ile Glu Gln Phe Tyr Leu Asp Lys Leu Lys Gln Arg Xaa Leu Glu 
    930                 935                 940                 


Gln Asn Arg Phe Gly Arg Leu Ser Val Arg Cys His Tyr Glu Ala Ala 
945                 950                 955                 960 


Glu Gln Arg Leu Ala Val Glu Val Leu His Ala Ala Asp Leu Leu Pro 
                965                 970                 975     


Leu Asp Ala Asn Gly Leu Ser Asp Pro Phe Val Ile Val Glu Leu Gly 
            980                 985                 990         


Pro Pro His Leu Phe Pro Leu Val  Arg Ser Gln Arg Xaa  Gln Val Lys 
        995                 1000                 1005             


Xaa Arg  Xaa Leu His Pro Val  Tyr Asp Glu Leu Phe  Tyr Phe Ser 
    1010                 1015                 1020             


Val Pro  Ala Glu Ala Cys Arg  Arg Arg Ala Ala Cys  Val Leu Phe 
    1025                 1030                 1035             


Xaa Val  Met Asp His Asp Trp  Leu Ser Xaa Asn Asp  Phe Ala Gly 
    1040                 1045                 1050             


Glu Ala  Ala Leu Gly Leu Gly  Gly Val Xaa Gly Val  Ala Arg Pro 
    1055                 1060                 1065             


Gln Val  Gly Gly Gly Ala Arg  Ala Gly Gln Pro Val  Xaa Leu His 
    1070                 1075                 1080             


Leu Cys  Arg Pro Arg Ala Gln  Val Arg Ser Ala Leu  Arg Arg Leu 
    1085                 1090                 1095             


Glu Gly  Arg Xaa Ser Lys Glu  Ala Gln Glu Phe Val  Lys Lys Leu 
    1100                 1105                 1110             


Lys Glu  Leu Glu Lys Cys Met  Glu Ala Asp Pro 
    1115                 1120                 


<210> 3890
<211> 1129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1107)..(1107)
<223> Selenocysteine

<400> 3890
Met Ser Xaa Leu Leu Asp Ile Lys Ser Ser Val Leu Arg Gln Val Gln 
1               5                   10                  15      


Val Cys Pro Ser Phe Arg Arg Arg Xaa Glu Gln Asp Pro Gly Ser Ala 
            20                  25                  30          


Ser Ala Asp Pro Gln Glu Pro Ala Xaa Gly Ala Trp Lys Pro Gly Asp 
        35                  40                  45              


Gly Val Glu Phe Phe Ala His Met Arg Leu Met Leu Lys Lys Gly Glu 
    50                  55                  60                  


Gly Arg Gln Gly Leu Pro Cys Leu Glu Val Pro Leu Arg Ser Gly Ser 
65                  70                  75                  80  


Pro Ala Pro Pro Glu Pro Val Asp Pro Ser Leu Gly Leu Arg Ala Leu 
                85                  90                  95      


Ala Pro Glu Glu Val Asp Asp Glu Glu Ala Leu Leu Ser Tyr Leu Gln 
            100                 105                 110         


Gln Val Phe Gly Xaa Ser Leu Glu Glu His Xaa Glu Ala Ile Glu Arg 
        115                 120                 125             


Val Arg Lys Ala Lys Ala Pro Xaa Tyr Ala Leu Lys Val Ser Val Met 
    130                 135                 140                 


Arg Ala Lys Asn Leu Leu Ala Lys Asp Pro Asn Gly Phe Ser Asp Pro 
145                 150                 155                 160 


Tyr Cys Met Leu Gly Ile Leu Pro Ala Ser Asp Ala Xaa Arg Glu Pro 
                165                 170                 175     


Arg Ala Gln Lys Glu Gln Arg Phe Gly Phe Arg Lys Gly Ser Lys Arg 
            180                 185                 190         


Gly Gly Pro Leu Pro Ala Lys Cys Ile Gln Val Xaa Glu Val Lys Ser 
        195                 200                 205             


Ser Xaa Leu Asn Pro Val Trp Lys Glu His Phe Leu Phe Glu Ile Glu 
    210                 215                 220                 


Asp Val Ser Xaa Asp Gln Leu His Leu Asp Ile Trp Asp His Asp Asp 
225                 230                 235                 240 


Asp Val Ser Leu Val Glu Ala Cys Arg Lys Leu Asn Glu Val Ile Gly 
                245                 250                 255     


Leu Lys Gly Met Gly Arg Tyr Phe Lys Gln Ile Val Lys Ser Ala Arg 
            260                 265                 270         


Ala Asn Gly Xaa Ala Gly Pro Xaa Glu Asp His Xaa Asp Asp Phe Leu 
        275                 280                 285             


Gly Cys Leu Asn Ile Pro Val Arg Glu Val Pro Val Ala Gly Val Asp 
    290                 295                 300                 


Arg Trp Phe Lys Leu Glu Pro Arg Ser Ser Ala Ser Arg Val Gln Gly 
305                 310                 315                 320 


His Cys His Leu Val Leu Lys Leu Ile Xaa Xaa Gln Arg Asp Xaa Ala 
                325                 330                 335     


Met Ser Gln Arg Gly Arg Ser Gly Phe Leu Ser His Leu Leu Leu Leu 
            340                 345                 350         


Ser His Leu Leu Arg Leu Glu His Ser Ala Glu Glu Pro Asn Ser Ser 
        355                 360                 365             


Ser Trp Arg Gly Glu Leu Ser Xaa Pro Ala Ala Xaa Ile Leu Cys Leu 
    370                 375                 380                 


His Gly Ala Gln Ser Asn Leu Ser Pro Leu Gln Leu Ala Val Leu His 
385                 390                 395                 400 


Trp Gln Val Ser Ser Arg His His Gln Xaa Cys Xaa Leu Asp Tyr Ser 
                405                 410                 415     


Tyr Leu Leu Gly Leu Leu Glu Asp Met Gln Ala His Trp Glu Glu Ala 
            420                 425                 430         


Pro Ser Leu Pro Gln Glu Gln Glu Glu Ser Leu Ala Asp Ser Leu Ser 
        435                 440                 445             


Ala Phe Ser Glu Phe Gly Leu Gln Leu Leu Arg Gln Leu Arg Asp Tyr 
    450                 455                 460                 


Phe Pro Ala Xaa Asn Ser Xaa Ala Val His Arg Leu Glu Leu Leu Leu 
465                 470                 475                 480 


Lys Cys Leu Gly Lys Leu Gln Leu Phe Gln Pro Ser Phe Glu Ile Cys 
                485                 490                 495     


Pro Phe Glu Ser Glu Leu Asn Met Asp Ile Ala Ala Ala Leu Lys Arg 
            500                 505                 510         


Gly Asn Arg Glu Trp Tyr Asp Arg Ile Leu Asn Asp Lys Ser Pro Arg 
        515                 520                 525             


Glu Gln Pro Gly Pro Gln Arg Leu Pro Gly Leu Val Val Leu Ala Asp 
    530                 535                 540                 


Ala Val Tyr Asp Asp Leu Gln Phe Cys Tyr Ser Val Tyr Ala Ser Leu 
545                 550                 555                 560 


Phe His Ser Ile Leu Asn Val Asp Val Phe Xaa Leu Xaa Phe Arg Gln 
                565                 570                 575     


Leu Glu Arg Leu Val Ala Glu Glu Ala Trp Val Leu Xaa Glu Glu Leu 
            580                 585                 590         


Ser Pro Lys Met Xaa Leu Glu Val Ala Ser Gly Leu Phe Glu Leu Tyr 
        595                 600                 605             


Leu Xaa Leu Ala Asp Leu Gln Arg Phe Trp Asp Ser Ile Pro Gly Arg 
    610                 615                 620                 


Asp Ser Arg Ser Leu Ala Leu Ala Gly Ile His Ala Pro Phe Leu Pro 
625                 630                 635                 640 


Ala Val Lys Leu Trp Phe Gln Val Leu Arg Asp Gln Ala Lys Trp Arg 
                645                 650                 655     


Leu Gln Gly Ala Val Asp Met Asp Xaa Leu Glu Pro Val Asp Ala Ser 
            660                 665                 670         


Ser Arg His Ser Ser Ser Ala Ala Xaa Ala Gly Leu Cys Leu Ser His 
        675                 680                 685             


Ile Gln Glu Leu Trp Val Arg Leu Ala Trp Pro Asp Pro Ala Gln Ala 
    690                 695                 700                 


Gln Gly Leu Gly Xaa Gln Leu Gly Gln Asp Val Cys Glu Ala Xaa Leu 
705                 710                 715                 720 


Phe Tyr Xaa Glu Leu Leu Arg Lys Lys Val Asp Xaa Gln Pro Gly Ala 
                725                 730                 735     


Ala Gly Glu Ala Val Ser Glu Ala Leu Cys Val Val Leu Asn Asn Val 
            740                 745                 750         


Glu Leu Val Arg Lys Ala Ala Gly Gln Ala Leu Lys Gly Leu Ala Trp 
        755                 760                 765             


Pro Glu Gly Ala Xaa Gly Pro Glu Gly Val Leu Pro Arg Pro Leu Leu 
    770                 775                 780                 


Ser Cys Xaa Gln Ala Leu Asp Asp Asp Leu Gln Arg Glu Ala His Xaa 
785                 790                 795                 800 


Val Xaa Ala His Leu Xaa Ser Lys Met Val Gly Asp Ile Arg Lys Tyr 
                805                 810                 815     


Val Gln His Ile Ser Leu Ser Pro Asp Ser Ile Gln Asn Asp Glu Ala 
            820                 825                 830         


Val Ala Pro Leu Met Lys Tyr Leu Asp Glu Lys Leu Ala Leu Leu Asn 
        835                 840                 845             


Ala Ser Leu Val Lys Gly Asn Leu Ser Arg Val Leu Glu Ala Leu Trp 
    850                 855                 860                 


Glu Leu Leu Leu Gln Ala Ile Leu Gln Ala Leu Gly Ala Asn Arg Asp 
865                 870                 875                 880 


Val Ser Ala Asp Phe Tyr Ser Arg Phe His Phe Xaa Leu Glu Ala Leu 
                885                 890                 895     


Val Ser Phe Phe His Ala Glu Gly Gln Gly Leu Pro Leu Glu Ser Leu 
            900                 905                 910         


Arg Asp Gly Ser Tyr Lys Arg Leu Lys Glu Glu Leu Arg Leu His Lys 
        915                 920                 925             


Cys Ser Xaa Arg Glu Cys Ile Glu Gln Phe Tyr Leu Asp Lys Leu Lys 
    930                 935                 940                 


Gln Arg Xaa Leu Glu Gln Asn Arg Phe Gly Arg Leu Ser Val Arg Cys 
945                 950                 955                 960 


His Tyr Glu Ala Ala Glu Gln Arg Leu Ala Val Glu Val Leu His Ala 
                965                 970                 975     


Ala Asp Leu Leu Pro Leu Asp Ala Asn Gly Leu Ser Asp Pro Phe Val 
            980                 985                 990         


Ile Val Glu Leu Gly Pro Pro His  Leu Phe Pro Leu Val  Arg Ser Gln 
        995                 1000                 1005             


Arg Xaa  Gln Val Lys Xaa Arg  Xaa Leu His Pro Val  Tyr Asp Glu 
    1010                 1015                 1020             


Leu Phe  Tyr Phe Ser Val Pro  Ala Glu Ala Cys Arg  Arg Arg Ala 
    1025                 1030                 1035             


Ala Cys  Val Leu Phe Xaa Val  Met Asp His Asp Trp  Leu Ser Xaa 
    1040                 1045                 1050             


Asn Asp  Phe Ala Gly Glu Ala  Ala Leu Gly Leu Gly  Gly Val Xaa 
    1055                 1060                 1065             


Gly Val  Ala Arg Pro Gln Val  Gly Gly Gly Ala Arg  Ala Gly Gln 
    1070                 1075                 1080             


Pro Val  Xaa Leu His Leu Cys  Arg Pro Arg Ala Gln  Val Arg Ser 
    1085                 1090                 1095             


Ala Leu  Arg Arg Leu Glu Gly  Arg Xaa Ser Lys Glu  Ala Gln Glu 
    1100                 1105                 1110             


Phe Val  Lys Lys Leu Lys Glu  Leu Glu Lys Cys Met  Glu Ala Asp 
    1115                 1120                 1125             


Pro 
    


<210> 3891
<211> 1116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<400> 3891
Met Ser Xaa Leu Leu Asp Ile Lys Ser Ser Val Leu Arg Gln Val Gln 
1               5                   10                  15      


Val Cys Pro Ser Phe Arg Arg Arg Xaa Glu Gln Asp Pro Gly Ser Ala 
            20                  25                  30          


Ser Ala Asp Pro Gln Glu Pro Ala Xaa Gly Ala Trp Lys Pro Gly Asp 
        35                  40                  45              


Gly Val Glu Phe Phe Ala His Met Arg Leu Met Leu Lys Lys Gly Glu 
    50                  55                  60                  


Gly Arg Gln Gly Leu Pro Cys Leu Glu Val Pro Leu Arg Ser Gly Ser 
65                  70                  75                  80  


Pro Ala Pro Pro Glu Pro Val Asp Pro Ser Leu Gly Leu Arg Ala Leu 
                85                  90                  95      


Ala Pro Glu Glu Val Glu Met Leu Tyr Glu Glu Ala Leu Tyr Xaa Val 
            100                 105                 110         


Leu Tyr Arg Ala Gly Xaa Met Gly Pro Asp Gln Val Asp Asp Glu Glu 
        115                 120                 125             


Ala Leu Leu Ser Tyr Leu Gln Gln Val Phe Gly Xaa Ser Leu Glu Glu 
    130                 135                 140                 


His Xaa Glu Ala Ile Glu Arg Val Arg Lys Ala Lys Ala Pro Xaa Tyr 
145                 150                 155                 160 


Ala Leu Lys Val Ser Val Met Arg Ala Lys Asn Leu Leu Ala Lys Asp 
                165                 170                 175     


Pro Asn Gly Phe Ser Asp Pro Tyr Cys Met Leu Gly Ile Leu Pro Ala 
            180                 185                 190         


Ser Asp Ala Xaa Arg Glu Pro Arg Ala Gln Lys Glu Gln Arg Phe Gly 
        195                 200                 205             


Phe Arg Lys Gly Ser Lys Arg Gly Gly Pro Leu Pro Ala Lys Cys Ile 
    210                 215                 220                 


Gln Val Xaa Glu Val Lys Ser Ser Xaa Leu Asn Pro Val Trp Lys Glu 
225                 230                 235                 240 


His Phe Leu Phe Glu Ile Glu Asp Val Ser Xaa Asp Gln Leu His Leu 
                245                 250                 255     


Asp Ile Trp Asp His Asp Asp Asp Val Ser Leu Val Glu Ala Cys Arg 
            260                 265                 270         


Lys Leu Asn Glu Val Ile Gly Leu Lys Gly Met Gly Arg Tyr Phe Lys 
        275                 280                 285             


Gln Ile Val Lys Ser Ala Arg Ala Asn Gly Xaa Ala Gly Pro Xaa Glu 
    290                 295                 300                 


Asp His Xaa Asp Asp Phe Leu Gly Cys Leu Asn Ile Pro Val Arg Arg 
305                 310                 315                 320 


Asp Xaa Ala Met Ser Gln Arg Gly Arg Ser Gly Phe Leu Ser His Leu 
                325                 330                 335     


Leu Leu Leu Ser His Leu Leu Arg Leu Glu His Ser Ala Glu Glu Pro 
            340                 345                 350         


Asn Ser Ser Ser Trp Arg Gly Glu Leu Ser Xaa Pro Ala Ala Xaa Ile 
        355                 360                 365             


Leu Cys Leu His Gly Ala Gln Ser Asn Leu Ser Pro Leu Gln Leu Ala 
    370                 375                 380                 


Val Leu His Trp Gln Val Ser Ser Arg His His Gln Xaa Cys Xaa Leu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Leu Leu Gly Leu Leu Glu Asp Met Gln Ala His Trp 
                405                 410                 415     


Glu Glu Ala Pro Ser Leu Pro Gln Glu Gln Glu Glu Ser Leu Ala Asp 
            420                 425                 430         


Ser Leu Ser Ala Phe Ser Glu Phe Gly Leu Gln Leu Leu Arg Gln Leu 
        435                 440                 445             


Arg Asp Tyr Phe Pro Ala Xaa Asn Ser Xaa Ala Val His Arg Leu Glu 
    450                 455                 460                 


Leu Leu Leu Lys Cys Leu Gly Lys Leu Gln Leu Phe Gln Pro Ser Phe 
465                 470                 475                 480 


Glu Ile Cys Pro Phe Glu Ser Glu Leu Asn Met Asp Ile Ala Ala Ala 
                485                 490                 495     


Leu Lys Arg Gly Asn Arg Glu Trp Tyr Asp Arg Ile Leu Asn Asp Lys 
            500                 505                 510         


Ser Pro Arg Glu Gln Pro Gly Pro Gln Arg Leu Pro Gly Leu Val Val 
        515                 520                 525             


Leu Ala Asp Ala Val Tyr Asp Asp Leu Gln Phe Cys Tyr Ser Val Tyr 
    530                 535                 540                 


Ala Ser Leu Phe His Ser Ile Leu Asn Val Asp Val Phe Xaa Leu Xaa 
545                 550                 555                 560 


Phe Arg Gln Leu Glu Arg Leu Val Ala Glu Glu Ala Trp Val Leu Xaa 
                565                 570                 575     


Glu Glu Leu Ser Pro Lys Met Xaa Leu Glu Val Ala Ser Gly Leu Phe 
            580                 585                 590         


Glu Leu Tyr Leu Xaa Leu Ala Asp Leu Gln Arg Phe Trp Asp Ser Ile 
        595                 600                 605             


Pro Gly Arg Asp Ser Arg Ser Leu Ala Leu Ala Gly Ile His Ala Pro 
    610                 615                 620                 


Phe Leu Pro Ala Val Lys Leu Trp Phe Gln Val Leu Arg Asp Gln Ala 
625                 630                 635                 640 


Lys Trp Arg Leu Gln Gly Ala Val Asp Met Asp Xaa Leu Glu Pro Val 
                645                 650                 655     


Asp Ala Ser Ser Arg His Ser Ser Ser Ala Ala Xaa Ala Gly Leu Cys 
            660                 665                 670         


Leu Ser His Ile Gln Glu Leu Trp Val Arg Leu Ala Trp Pro Asp Pro 
        675                 680                 685             


Ala Gln Ala Gln Gly Leu Gly Xaa Gln Leu Gly Gln Asp Val Cys Glu 
    690                 695                 700                 


Ala Xaa Leu Phe Tyr Xaa Glu Leu Leu Arg Lys Lys Val Asp Xaa Gln 
705                 710                 715                 720 


Pro Gly Ala Ala Gly Glu Ala Val Ser Glu Ala Leu Cys Val Val Leu 
                725                 730                 735     


Asn Asn Val Glu Leu Val Arg Lys Ala Ala Gly Gln Ala Leu Lys Gly 
            740                 745                 750         


Leu Ala Trp Pro Glu Gly Ala Xaa Gly Pro Glu Gly Val Leu Pro Arg 
        755                 760                 765             


Pro Leu Leu Ser Cys Xaa Gln Ala Leu Asp Asp Asp Leu Gln Arg Glu 
    770                 775                 780                 


Ala His Xaa Val Xaa Ala His Leu Xaa Ser Lys Met Val Gly Asp Ile 
785                 790                 795                 800 


Arg Lys Tyr Val Gln His Ile Ser Leu Ser Pro Asp Ser Ile Gln Asn 
                805                 810                 815     


Asp Glu Ala Val Ala Pro Leu Met Lys Tyr Leu Asp Glu Lys Leu Ala 
            820                 825                 830         


Leu Leu Asn Ala Ser Leu Val Lys Gly Asn Leu Ser Arg Val Leu Glu 
        835                 840                 845             


Ala Leu Trp Glu Leu Leu Leu Gln Ala Ile Leu Gln Ala Leu Gly Ala 
    850                 855                 860                 


Asn Arg Asp Val Ser Ala Asp Phe Tyr Ser Arg Phe His Phe Xaa Leu 
865                 870                 875                 880 


Glu Ala Leu Val Ser Phe Phe His Ala Glu Gly Gln Gly Leu Pro Leu 
                885                 890                 895     


Glu Ser Leu Arg Asp Gly Ser Tyr Lys Arg Leu Lys Glu Glu Leu Arg 
            900                 905                 910         


Leu His Lys Cys Ser Xaa Arg Glu Cys Ile Glu Gln Phe Tyr Leu Asp 
        915                 920                 925             


Lys Leu Lys Gln Arg Xaa Leu Glu Gln Asn Arg Phe Gly Arg Leu Ser 
    930                 935                 940                 


Val Arg Cys His Tyr Glu Ala Ala Glu Gln Arg Leu Ala Val Glu Val 
945                 950                 955                 960 


Leu His Ala Ala Asp Leu Leu Pro Leu Asp Ala Asn Gly Leu Ser Asp 
                965                 970                 975     


Pro Phe Val Ile Val Glu Leu Gly Pro Pro His Leu Phe Pro Leu Val 
            980                 985                 990         


Arg Ser Gln Arg Xaa Gln Val Lys  Xaa Arg Xaa Leu His  Pro Val Tyr 
        995                 1000                 1005             


Asp Glu  Leu Phe Tyr Phe Ser  Val Pro Ala Glu Ala  Cys Arg Arg 
    1010                 1015                 1020             


Arg Ala  Ala Cys Val Leu Phe  Xaa Val Met Asp His  Asp Trp Leu 
    1025                 1030                 1035             


Ser Xaa  Asn Asp Phe Ala Gly  Glu Ala Ala Leu Gly  Leu Gly Gly 
    1040                 1045                 1050             


Val Xaa  Gly Val Ala Arg Pro  Gln Val Gly Gly Gly  Ala Arg Ala 
    1055                 1060                 1065             


Gly Gln  Pro Val Xaa Leu His  Leu Cys Arg Pro Arg  Ala Gln Val 
    1070                 1075                 1080             


Arg Ser  Ala Leu Arg Arg Leu  Glu Gly Arg Xaa Ser  Lys Glu Ala 
    1085                 1090                 1095             


Gln Glu  Phe Val Lys Lys Leu  Lys Glu Leu Glu Lys  Cys Met Glu 
    1100                 1105                 1110             


Ala Asp  Pro 
    1115     


<210> 3892
<211> 1152
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1091)..(1091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<400> 3892
Met Ser Xaa Leu Leu Asp Ile Lys Ser Ser Val Leu Arg Gln Val Gln 
1               5                   10                  15      


Val Cys Pro Ser Phe Arg Arg Arg Xaa Glu Gln Asp Pro Gly Ser Ala 
            20                  25                  30          


Ser Ala Asp Pro Gln Glu Pro Ala Xaa Gly Ala Trp Lys Pro Gly Asp 
        35                  40                  45              


Gly Val Glu Phe Phe Ala His Met Arg Leu Met Leu Lys Lys Gly Glu 
    50                  55                  60                  


Gly Arg Gln Gly Leu Pro Cys Leu Glu Val Pro Leu Arg Ser Gly Ser 
65                  70                  75                  80  


Pro Ala Pro Pro Glu Pro Val Asp Pro Ser Leu Gly Leu Arg Ala Leu 
                85                  90                  95      


Ala Pro Glu Glu Val Glu Met Leu Tyr Glu Glu Ala Leu Tyr Xaa Val 
            100                 105                 110         


Leu Tyr Arg Ala Gly Xaa Met Gly Pro Asp Gln Val Asp Asp Glu Glu 
        115                 120                 125             


Ala Leu Leu Ser Tyr Leu Gln Gln Val Phe Gly Xaa Ser Leu Glu Glu 
    130                 135                 140                 


His Xaa Glu Ala Ile Glu Arg Val Arg Lys Ala Lys Ala Pro Xaa Tyr 
145                 150                 155                 160 


Ala Leu Lys Val Ser Val Met Arg Ala Lys Asn Leu Leu Ala Lys Asp 
                165                 170                 175     


Pro Asn Gly Phe Ser Asp Pro Tyr Cys Met Leu Gly Ile Leu Pro Ala 
            180                 185                 190         


Ser Asp Ala Xaa Arg Glu Pro Arg Ala Gln Lys Glu Gln Arg Phe Gly 
        195                 200                 205             


Phe Arg Lys Gly Ser Lys Arg Gly Gly Pro Leu Pro Ala Lys Cys Ile 
    210                 215                 220                 


Gln Val Xaa Glu Val Lys Ser Ser Xaa Leu Asn Pro Val Trp Lys Glu 
225                 230                 235                 240 


His Phe Leu Phe Glu Ile Glu Asp Val Ser Xaa Asp Gln Leu His Leu 
                245                 250                 255     


Asp Ile Trp Asp His Asp Asp Asp Val Ser Leu Val Glu Ala Cys Arg 
            260                 265                 270         


Lys Leu Asn Glu Val Ile Gly Leu Lys Gly Met Gly Arg Tyr Phe Lys 
        275                 280                 285             


Gln Ile Val Lys Ser Ala Arg Ala Asn Gly Xaa Ala Gly Pro Xaa Glu 
    290                 295                 300                 


Asp His Xaa Asp Asp Phe Leu Gly Cys Leu Asn Ile Pro Val Arg Glu 
305                 310                 315                 320 


Val Pro Val Ala Gly Val Asp Arg Trp Phe Lys Leu Glu Pro Arg Ser 
                325                 330                 335     


Ser Ala Ser Arg Val Gln Gly His Cys His Leu Val Leu Lys Leu Ile 
            340                 345                 350         


Xaa Xaa Gln Arg Asp Xaa Ala Met Ser Gln Arg Gly Arg Ser Gly Phe 
        355                 360                 365             


Leu Ser His Leu Leu Leu Leu Ser His Leu Leu Arg Leu Glu His Ser 
    370                 375                 380                 


Ala Glu Glu Pro Asn Ser Ser Ser Trp Arg Gly Glu Leu Ser Xaa Pro 
385                 390                 395                 400 


Ala Ala Xaa Ile Leu Cys Leu His Gly Ala Gln Ser Asn Leu Ser Pro 
                405                 410                 415     


Leu Gln Leu Ala Val Leu His Trp Gln Val Ser Ser Arg His His Gln 
            420                 425                 430         


Xaa Cys Xaa Leu Asp Tyr Ser Tyr Leu Leu Gly Leu Leu Glu Asp Met 
        435                 440                 445             


Gln Ala His Trp Glu Glu Ala Pro Ser Leu Pro Gln Glu Gln Glu Glu 
    450                 455                 460                 


Ser Leu Ala Asp Ser Leu Ser Ala Phe Ser Glu Phe Gly Leu Gln Leu 
465                 470                 475                 480 


Leu Arg Gln Leu Arg Asp Tyr Phe Pro Ala Xaa Asn Ser Xaa Ala Val 
                485                 490                 495     


His Arg Leu Glu Leu Leu Leu Lys Cys Leu Gly Lys Leu Gln Leu Phe 
            500                 505                 510         


Gln Pro Ser Phe Glu Ile Cys Pro Phe Glu Ser Glu Leu Asn Met Asp 
        515                 520                 525             


Ile Ala Ala Ala Leu Lys Arg Gly Asn Arg Glu Trp Tyr Asp Arg Ile 
    530                 535                 540                 


Leu Asn Asp Lys Ser Pro Arg Glu Gln Pro Gly Pro Gln Arg Leu Pro 
545                 550                 555                 560 


Gly Leu Val Val Leu Ala Asp Ala Val Tyr Asp Asp Leu Gln Phe Cys 
                565                 570                 575     


Tyr Ser Val Tyr Ala Ser Leu Phe His Ser Ile Leu Asn Val Asp Val 
            580                 585                 590         


Phe Xaa Leu Xaa Phe Arg Gln Leu Glu Arg Leu Val Ala Glu Glu Ala 
        595                 600                 605             


Trp Val Leu Xaa Glu Glu Leu Ser Pro Lys Met Xaa Leu Glu Val Ala 
    610                 615                 620                 


Ser Gly Leu Phe Glu Leu Tyr Leu Xaa Leu Ala Asp Leu Gln Arg Phe 
625                 630                 635                 640 


Trp Asp Ser Ile Pro Gly Arg Asp Ser Arg Ser Leu Ala Leu Ala Gly 
                645                 650                 655     


Ile His Ala Pro Phe Leu Pro Ala Val Lys Leu Trp Phe Gln Val Leu 
            660                 665                 670         


Arg Asp Gln Ala Lys Trp Arg Leu Gln Gly Ala Val Asp Met Asp Xaa 
        675                 680                 685             


Leu Glu Pro Val Asp Ala Ser Ser Arg His Ser Ser Ser Ala Ala Xaa 
    690                 695                 700                 


Ala Gly Leu Cys Leu Ser His Ile Gln Glu Leu Trp Val Arg Leu Ala 
705                 710                 715                 720 


Trp Pro Asp Pro Ala Gln Ala Gln Gly Leu Gly Xaa Gln Leu Gly Gln 
                725                 730                 735     


Asp Val Cys Glu Ala Xaa Leu Phe Tyr Xaa Glu Leu Leu Arg Lys Lys 
            740                 745                 750         


Val Asp Xaa Gln Pro Gly Ala Ala Gly Glu Ala Val Ser Glu Ala Leu 
        755                 760                 765             


Cys Val Val Leu Asn Asn Val Glu Leu Val Arg Lys Ala Ala Gly Gln 
    770                 775                 780                 


Ala Leu Lys Gly Leu Ala Trp Pro Glu Gly Ala Xaa Gly Pro Glu Gly 
785                 790                 795                 800 


Val Leu Pro Arg Pro Leu Leu Ser Cys Xaa Gln Ala Leu Asp Asp Asp 
                805                 810                 815     


Leu Gln Arg Glu Ala His Xaa Val Xaa Ala His Leu Xaa Ser Lys Met 
            820                 825                 830         


Val Gly Asp Ile Arg Lys Tyr Val Gln His Ile Ser Leu Ser Pro Asp 
        835                 840                 845             


Ser Ile Gln Asn Asp Glu Ala Val Ala Pro Leu Met Lys Tyr Leu Asp 
    850                 855                 860                 


Glu Lys Leu Ala Leu Leu Asn Ala Ser Leu Val Lys Gly Asn Leu Ser 
865                 870                 875                 880 


Arg Val Leu Glu Ala Leu Trp Glu Leu Leu Leu Gln Ala Ile Leu Gln 
                885                 890                 895     


Ala Leu Gly Ala Asn Arg Asp Val Ser Ala Asp Phe Tyr Ser Arg Phe 
            900                 905                 910         


His Phe Xaa Leu Glu Ala Leu Val Ser Phe Phe His Ala Glu Gly Gln 
        915                 920                 925             


Gly Leu Pro Leu Glu Ser Leu Arg Asp Gly Ser Tyr Lys Arg Leu Lys 
    930                 935                 940                 


Glu Glu Leu Arg Leu His Lys Cys Ser Xaa Arg Glu Cys Ile Glu Gln 
945                 950                 955                 960 


Phe Tyr Leu Asp Lys Leu Lys Gln Arg Xaa Leu Glu Gln Asn Arg Phe 
                965                 970                 975     


Gly Arg Leu Ser Val Arg Cys His Tyr Glu Ala Ala Glu Gln Arg Leu 
            980                 985                 990         


Ala Val Glu Val Leu His Ala Ala  Asp Leu Leu Pro Leu  Asp Ala Asn 
        995                 1000                 1005             


Gly Leu  Ser Asp Pro Phe Val  Ile Val Glu Leu Gly  Pro Pro His 
    1010                 1015                 1020             


Leu Phe  Pro Leu Val Arg Ser  Gln Arg Xaa Gln Val  Lys Xaa Arg 
    1025                 1030                 1035             


Xaa Leu  His Pro Val Tyr Asp  Glu Leu Phe Tyr Phe  Ser Val Pro 
    1040                 1045                 1050             


Ala Glu  Ala Cys Arg Arg Arg  Ala Ala Cys Val Leu  Phe Xaa Val 
    1055                 1060                 1065             


Met Asp  His Asp Trp Leu Ser  Xaa Asn Asp Phe Ala  Gly Glu Ala 
    1070                 1075                 1080             


Ala Leu  Gly Leu Gly Gly Val  Xaa Gly Val Ala Arg  Pro Gln Val 
    1085                 1090                 1095             


Gly Gly  Gly Ala Arg Ala Gly  Gln Pro Val Xaa Leu  His Leu Cys 
    1100                 1105                 1110             


Arg Pro  Arg Ala Gln Val Arg  Ser Ala Leu Arg Arg  Leu Glu Gly 
    1115                 1120                 1125             


Arg Xaa  Ser Lys Glu Ala Gln  Glu Phe Val Lys Lys  Leu Lys Glu 
    1130                 1135                 1140             


Leu Glu  Lys Cys Met Glu Ala  Asp Pro 
    1145                 1150         


<210> 3893
<211> 217
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<400> 3893
Xaa Tyr Ser Val Tyr Ala Ser Leu Phe His Ser Ile Leu Asn Val Asp 
1               5                   10                  15      


Val Phe Xaa Leu Xaa Phe Arg Gln Leu Glu Arg Leu Val Ala Glu Glu 
            20                  25                  30          


Ala Trp Val Leu Xaa Glu Glu Leu Ser Pro Lys Met Xaa Leu Glu Val 
        35                  40                  45              


Ala Ser Gly Leu Phe Glu Leu Tyr Leu Xaa Leu Ala Asp Leu Gln Arg 
    50                  55                  60                  


Phe Trp Asp Ser Ile Pro Gly Arg Asp Ser Arg Ser Leu Ala Leu Ala 
65                  70                  75                  80  


Gly Ile His Ala Pro Phe Leu Pro Ala Val Lys Leu Trp Phe Gln Val 
                85                  90                  95      


Leu Arg Asp Gln Ala Lys Trp Arg Leu Gln Gly Ala Val Asp Met Asp 
            100                 105                 110         


Xaa Leu Glu Pro Val Asp Ala Ser Ser Arg His Ser Ser Ser Ala Ala 
        115                 120                 125             


Xaa Ala Gly Leu Cys Leu Ser His Ile Gln Glu Leu Trp Val Arg Leu 
    130                 135                 140                 


Ala Trp Pro Asp Pro Ala Gln Ala Gln Gly Leu Gly Xaa Gln Leu Gly 
145                 150                 155                 160 


Gln Asp Val Cys Glu Ala Xaa Leu Phe Tyr Xaa Glu Leu Leu Arg Lys 
                165                 170                 175     


Lys Val Asp Xaa Gln Pro Gly Ala Ala Gly Glu Ala Val Ser Glu Ala 
            180                 185                 190         


Leu Cys Val Val Leu Asn Asn Val Glu Leu Val Arg Lys Ala Ala Gly 
        195                 200                 205             


Gln Ala His Leu Cys Pro Ser Cys Leu 
    210                 215         


<210> 3894
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<400> 3894
Xaa Tyr Xaa Glu Leu Leu Arg Lys Lys Val Asp Xaa Gln Pro Gly Ala 
1               5                   10                  15      


Ala Gly Glu Ala Val Ser Glu Ala Leu Cys Val Val Leu Asn Asn Val 
            20                  25                  30          


Glu Leu Val Arg Lys Ala Ala Gly Gln Ala Leu Lys Gly Leu Ala Trp 
        35                  40                  45              


Pro Glu Gly Ala Xaa Gly Pro Glu Gly Val Leu Pro Arg Pro Leu Leu 
    50                  55                  60                  


Ser Cys Xaa Gln Ala Leu Asp Asp Asp Leu Gln Arg Glu Ala His Xaa 
65                  70                  75                  80  


Val Xaa Ala His Leu Xaa Ser Lys Met Val Gly Asp Ile Arg Lys Tyr 
                85                  90                  95      


Val Gln His Ile Ser Leu Ser Pro Asp Ser Ile Gln Asn Asp Glu Ala 
            100                 105                 110         


Val Ala Pro Leu Met Lys Tyr Leu Asp Glu Lys Leu Ala Leu Leu Asn 
        115                 120                 125             


Ala Ser Leu Val Lys Gly Asn Leu Ser Ser Arg Phe His Phe Xaa Leu 
    130                 135                 140                 


Glu Ala Leu Val Ser Phe Phe His Ala Glu Gly Gln Gly Leu Pro Leu 
145                 150                 155                 160 


Glu Ser Leu Arg Asp Gly Ser Tyr Lys Arg Leu Lys Glu Glu Leu Arg 
                165                 170                 175     


Leu His Lys Cys Ser Xaa Arg Glu Cys Ile Glu Gln Phe Tyr Leu 
            180                 185                 190     


<210> 3895
<211> 153
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 3895
Met Ala Ser Gly Gln Gly Pro Gly Pro Pro Arg Gln Glu Cys Gly Glu 
1               5                   10                  15      


Pro Ala Leu Pro Ser Ala Ser Glu Glu Gln Val Ala Gln Asp Xaa Glu 
            20                  25                  30          


Glu Val Phe Arg Ser Tyr Val Phe Tyr Arg His Gln Gln Glu Gln Glu 
        35                  40                  45              


Ala Glu Gly Val Ala Ala Pro Ala Asp Pro Glu Met Val Xaa Leu Pro 
    50                  55                  60                  


Leu Gln Pro Ser Ser Xaa Met Gly Gln Val Gly Arg Gln Leu Ala Ile 
65                  70                  75                  80  


Ile Gly Asp Asp Ile Asn Arg Arg Tyr Asp Ser Glu Phe Gln Xaa Met 
                85                  90                  95      


Leu Gln His Leu Gln Pro Xaa Ala Glu Asn Ala Tyr Glu Tyr Phe Xaa 
            100                 105                 110         


Lys Ile Ala Xaa Arg Pro Ala Ala Xaa Pro Xaa Ala Cys Leu Arg Val 
        115                 120                 125             


Ala Ser Ile Gly Ala Val Trp Trp Leu Phe Trp Ala Ser Ala Xaa Val 
    130                 135                 140                 


Trp Pro Tyr Xaa Ser Xaa Ser Met Ala 
145                 150             


<210> 3896
<211> 211
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<400> 3896
Met Ala Ser Gly Gln Gly Pro Gly Pro Pro Arg Gln Glu Cys Gly Glu 
1               5                   10                  15      


Pro Ala Leu Pro Ser Ala Ser Glu Glu Gln Val Ala Gln Asp Xaa Glu 
            20                  25                  30          


Glu Val Phe Arg Ser Tyr Val Phe Tyr Arg His Gln Gln Glu Gln Glu 
        35                  40                  45              


Ala Glu Gly Val Ala Ala Pro Ala Asp Pro Glu Met Val Xaa Leu Pro 
    50                  55                  60                  


Leu Gln Pro Ser Ser Xaa Met Gly Gln Val Gly Arg Gln Leu Ala Ile 
65                  70                  75                  80  


Ile Gly Asp Asp Ile Asn Arg Arg Tyr Asp Ser Glu Phe Gln Xaa Met 
                85                  90                  95      


Leu Gln His Leu Gln Pro Xaa Ala Glu Asn Ala Tyr Glu Tyr Phe Xaa 
            100                 105                 110         


Lys Ile Ala Xaa Ser Leu Phe Glu Ser Gly Ile Asn Trp Gly Arg Val 
        115                 120                 125             


Val Ala Leu Leu Gly Phe Gly Tyr Arg Leu Ala Leu His Val Tyr Gln 
    130                 135                 140                 


His Gly Leu Xaa Gly Phe Leu Gly Gln Val Xaa Arg Phe Val Val Asp 
145                 150                 155                 160 


Phe Met Leu His His Cys Ile Ala Arg Trp Ile Ala Gln Arg Gly Gly 
                165                 170                 175     


Trp Val Ala Ala Leu Asn Leu Gly Asn Gly Pro Ile Leu Asn Val Leu 
            180                 185                 190         


Val Val Leu Gly Val Val Leu Leu Gly Gln Phe Val Val Arg Arg Phe 
        195                 200                 205             


Phe Lys Ser 
    210     


<210> 3897
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<400> 3897
Met Ala Ser Gly Gln Gly Pro Gly Pro Pro Arg Gln Glu Cys Gly Glu 
1               5                   10                  15      


Pro Ala Leu Pro Ser Ala Ser Glu Glu Gln Val Ala Gln Asp Xaa Glu 
            20                  25                  30          


Glu Val Phe Arg Ser Tyr Val Phe Tyr Arg His Gln Gln Gln Pro Ser 
        35                  40                  45              


Ser Xaa Met Gly Gln Val Gly Arg Gln Leu Ala Ile Ile Gly Asp Asp 
    50                  55                  60                  


Ile Asn Arg Arg Tyr Asp Ser Glu Phe Gln Xaa Met Leu Gln His Leu 
65                  70                  75                  80  


Gln Pro Xaa Ala Glu Asn Ala Tyr Glu Tyr Phe Xaa Lys Ile Ala Xaa 
                85                  90                  95      


Ser Leu Phe Glu Ser Gly Ile Asn Trp Gly Arg Val Val Ala Leu Leu 
            100                 105                 110         


Gly Phe Gly Tyr Arg Leu Ala Leu His Val Tyr Gln His Gly Leu Xaa 
        115                 120                 125             


Gly Phe Leu Gly Gln Val Xaa Arg Phe Val Val Asp Phe Met Leu His 
    130                 135                 140                 


His Cys Ile Ala Arg Trp Ile Ala Gln Arg Gly Gly Trp Val Ala Ala 
145                 150                 155                 160 


Leu Asn Leu Gly Asn Gly Pro Ile Leu Asn Val Leu Val Val Leu Gly 
                165                 170                 175     


Val Val Leu Leu Gly Gln Phe Val Val Arg Arg Phe Phe Lys Ser 
            180                 185                 190     


<210> 3898
<211> 260
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<400> 3898
Met Asp Arg His Ser Ser Tyr Ile Phe Ile Trp Leu Gln Leu Glu Leu 
1               5                   10                  15      


Cys Ala Met Ala Val Leu Leu Xaa Lys Gly Glu Ile Arg Cys Tyr Cys 
            20                  25                  30          


Asp Ala Ala His Cys Val Ala Xaa Gly Tyr Met Cys Lys Ser Glu Leu 
        35                  40                  45              


Ser Ala Cys Phe Ser Arg Leu Leu Asp Pro Gln Asn Ser Asn Ser Pro 
    50                  55                  60                  


Leu Xaa His Gly Cys Leu Asp Ser Leu Ala Ser Xaa Xaa Asp Ile Cys 
65                  70                  75                  80  


Gln Ala Lys Gln Ala Arg Asn His Ser Gly Xaa Xaa Ile Pro Xaa Leu 
                85                  90                  95      


Glu Cys Cys His Glu Asp Met Cys Asn Tyr Arg Gly Leu His Asp Val 
            100                 105                 110         


Leu Ser Pro Pro Arg Gly Glu Ala Ser Gly Gln Gly Asn Arg Tyr Gln 
        115                 120                 125             


His Asp Gly Ser Arg Asn Leu Ile Xaa Lys Val Gln Glu Leu Xaa Ser 
    130                 135                 140                 


Ser Lys Glu Leu Trp Phe Arg Ala Ala Val Ile Ala Val Pro Ile Ala 
145                 150                 155                 160 


Gly Gly Leu Ile Leu Val Leu Leu Ile Met Leu Ala Leu Arg Met Leu 
                165                 170                 175     


Arg Ser Glu Asn Lys Arg Leu Gln Asp Gln Arg Gln Gln Met Leu Ser 
            180                 185                 190         


Arg Leu His Tyr Ser Phe His Gly His His Ser Lys Lys Gly Gln Val 
        195                 200                 205             


Ala Lys Leu Asp Leu Glu Cys Met Val Pro Val Ser Gly His Glu Asn 
    210                 215                 220                 


Cys Cys Leu Xaa Cys Asp Lys Met Arg Gln Ala Asp Leu Ser Asn Asp 
225                 230                 235                 240 


Lys Ile Leu Ser Leu Val His Trp Gly Met Tyr Ser Gly His Gly Lys 
                245                 250                 255     


Leu Glu Phe Val 
            260 


<210> 3899
<211> 755
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<400> 3899
Met Ile Tyr Glu Glu Asp Ala Glu Glu Trp Ala Leu Tyr Leu Xaa Glu 
1               5                   10                  15      


Val Phe Leu His Val Val Lys Arg Glu Ala Ile Leu Leu Tyr Arg Leu 
            20                  25                  30          


Glu Asn Phe Ser Phe Arg His Leu Glu Leu Leu Asn Leu Xaa Ser Tyr 
        35                  40                  45              


Lys Cys Lys Leu Leu Ile Leu Ser Asn Ser Leu Leu Arg Asp Leu Xaa 
    50                  55                  60                  


Pro Lys Lys Cys Gln Phe Leu Glu Lys Ile Leu His Ser Pro Lys Ser 
65                  70                  75                  80  


Val Val Xaa Leu Leu Cys Gly Val Lys Ser Ser Asp Gln Leu Tyr Glu 
                85                  90                  95      


Leu Leu Asn Ile Ser Gln Ser Arg Trp Glu Ile Ser Xaa Glu Gln Glu 
            100                 105                 110         


Pro Glu Asp Tyr Ile Ser Val Ile Gln Ser Ile Ile Phe Lys Asp Ser 
        115                 120                 125             


Glu Asp Tyr Phe Glu Val Asn Ile Pro Xaa Asp Leu Arg Ala Lys His 
    130                 135                 140                 


Ser Gly Glu Ile Ser Glu Arg Lys Glu Ile Glu Glu Leu Ser Glu Ala 
145                 150                 155                 160 


Ser Arg Asn Xaa Ile Pro Leu Ala Val Val Leu Pro Xaa Glu Ile Pro 
                165                 170                 175     


Cys Glu Asn Pro Gly Glu Ile Phe Ile Ile Leu Arg Asp Glu Val Ile 
            180                 185                 190         


Gly Asp Xaa Val Glu Val Glu Phe Xaa Ser Ser Asn Lys Arg Ile Arg 
        195                 200                 205             


Xaa Arg Pro Ala Leu Trp Asn Lys Lys Val Trp Cys Met Lys Ala Leu 
    210                 215                 220                 


Glu Phe Pro Ala Gly Ser Val His Val Asn Val Tyr Cys Asp Gly Ile 
225                 230                 235                 240 


Val Lys Ala Xaa Xaa Lys Ile Lys Tyr Tyr Pro Xaa Ala Lys Ala Lys 
                245                 250                 255     


Glu Cys Leu Phe Arg Met Ala Asp Ser Gly Glu Ser Leu Cys Gln Asn 
            260                 265                 270         


Ser Ile Glu Glu Leu Asp Gly Val Leu Xaa Ser Ile Phe Lys His Glu 
        275                 280                 285             


Ile Pro Tyr Tyr Glu Phe Gln Ser Leu Gln Xaa Glu Ile Cys Ser Gln 
    290                 295                 300                 


Asn Lys Tyr Xaa His Phe Lys Glu Leu Pro Xaa Leu Leu His Cys Ala 
305                 310                 315                 320 


Ala Lys Phe Gly Leu Lys Asn Leu Ala Ile His Leu Leu Gln Cys Ser 
                325                 330                 335     


Gly Ala Xaa Trp Ala Ser Lys Met Lys Asn Met Glu Gly Ser Asp Pro 
            340                 345                 350         


Ala His Ile Ala Glu Arg His Gly His Lys Glu Leu Lys Lys Ile Phe 
        355                 360                 365             


Glu Asp Phe Ser Ile Gln Glu Ile Asp Ile Asn Asn Glu Gln Glu Asn 
    370                 375                 380                 


Asp Tyr Glu Glu Asp Ile Ala Ser Phe Ser Xaa Tyr Ile Pro Ser Xaa 
385                 390                 395                 400 


Gln Asn Pro Ala Phe His His Glu Ser Arg Lys Xaa Tyr Gly Gln Ser 
                405                 410                 415     


Ala Asp Gly Ala Glu Ala Asn Glu Met Glu Gly Glu Gly Lys Gln Asn 
            420                 425                 430         


Gly Ser Gly Met Glu Xaa Lys His Ser Pro Leu Glu Val Gly Ser Glu 
        435                 440                 445             


Ser Ser Glu Asp Gln Tyr Asp Asp Leu Tyr Val Phe Ile Pro Gly Ala 
    450                 455                 460                 


Asp Pro Glu Asn Asn Ser Gln Glu Pro Leu Met Ser Ser Arg Pro Pro 
465                 470                 475                 480 


Leu Pro Pro Pro Arg Pro Val Ala Asn Ala Phe Gln Leu Glu Arg Pro 
                485                 490                 495     


His Phe Xaa Leu Pro Gly Xaa Met Val Glu Gly Gln Met Glu Arg Ser 
            500                 505                 510         


Gln Asn Trp Gly His Pro Gly Val Arg Gln Glu Xaa Gly Asp Glu Pro 
        515                 520                 525             


Lys Gly Glu Lys Glu Lys Lys Glu Glu Glu Lys Glu Gln Glu Glu Glu 
    530                 535                 540                 


Glu Asp Pro Tyr Xaa Phe Ala Glu Ile Asp Asp Ser Glu Tyr Asp Met 
545                 550                 555                 560 


Ile Leu Ala Asn Leu Ser Ile Lys Lys Lys Xaa Gly Ser Arg Ser Phe 
                565                 570                 575     


Ile Ile Asn Arg Pro Pro Ala Pro Xaa Pro Arg Pro Xaa Ser Ile Pro 
            580                 585                 590         


Pro Lys Glu Glu Xaa Xaa Pro Tyr Ile Ala Gln Val Phe Gln Gln Lys 
        595                 600                 605             


Xaa Ala Arg Arg Gln Ser Asp Asp Asp Lys Phe Cys Gly Leu Pro Lys 
    610                 615                 620                 


Lys Gln Asp Arg Ala Arg Ile Glu Ser Pro Ala Phe Ser Xaa Leu Arg 
625                 630                 635                 640 


Gly Cys Leu Xaa Asp Gly Gln Glu Glu Leu Ile Leu Leu Gln Glu Lys 
                645                 650                 655     


Val Lys Asn Gly Lys Met Ser Met Asp Glu Ala Leu Glu Lys Phe Lys 
            660                 665                 670         


His Trp Gln Met Gly Lys Ser Gly Leu Glu Met Ile Gln Gln Glu Lys 
        675                 680                 685             


Leu Arg Gln Leu Arg Asp Cys Ile Ile Gly Lys Arg Pro Glu Glu Glu 
    690                 695                 700                 


Asn Val Tyr Asn Lys Leu Xaa Ile Val His His Pro Gly Gly Lys Glu 
705                 710                 715                 720 


Xaa Ala His Asn Glu Asn Lys Phe Tyr Asn Val His Phe Ser Asn Lys 
                725                 730                 735     


Leu Pro Ala Arg Pro Gln Val Glu Lys Glu Phe Gly Phe Cys Cys Lys 
            740                 745                 750         


Lys Asp His 
        755 


<210> 3900
<211> 652
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<400> 3900
Met Leu Pro Ala Ala Pro Gly Lys Gly Leu Gly Ser Pro Asp Pro Ala 
1               5                   10                  15      


Pro Cys Gly Pro Ala Pro Pro Asp Ser Glu Asp Tyr Phe Glu Val Asn 
            20                  25                  30          


Ile Pro Xaa Asp Leu Arg Ala Lys His Ser Gly Glu Ile Ser Glu Arg 
        35                  40                  45              


Lys Glu Ile Glu Glu Leu Ser Glu Ala Ser Arg Asn Xaa Ile Pro Leu 
    50                  55                  60                  


Ala Val Val Leu Pro Xaa Glu Ile Pro Cys Glu Asn Pro Gly Glu Ile 
65                  70                  75                  80  


Phe Ile Ile Leu Arg Asp Glu Val Ile Gly Asp Xaa Val Glu Val Glu 
                85                  90                  95      


Phe Xaa Ser Ser Asn Lys Arg Ile Arg Xaa Arg Pro Ala Leu Trp Asn 
            100                 105                 110         


Lys Lys Val Trp Cys Met Lys Ala Leu Glu Phe Pro Ala Gly Ser Val 
        115                 120                 125             


His Val Asn Val Tyr Cys Asp Gly Ile Val Lys Ala Xaa Xaa Lys Ile 
    130                 135                 140                 


Lys Tyr Tyr Pro Xaa Ala Lys Ala Lys Glu Cys Leu Phe Arg Met Ala 
145                 150                 155                 160 


Asp Ser Gly Glu Ser Leu Cys Gln Asn Ser Ile Glu Glu Leu Asp Gly 
                165                 170                 175     


Val Leu Xaa Ser Ile Phe Lys His Glu Ile Pro Tyr Tyr Glu Phe Gln 
            180                 185                 190         


Ser Leu Gln Xaa Glu Ile Cys Ser Gln Asn Lys Tyr Xaa His Phe Lys 
        195                 200                 205             


Glu Leu Pro Xaa Leu Leu His Cys Ala Ala Lys Phe Gly Leu Lys Asn 
    210                 215                 220                 


Leu Ala Ile His Leu Leu Gln Cys Ser Gly Ala Xaa Trp Ala Ser Lys 
225                 230                 235                 240 


Met Lys Asn Met Glu Gly Ser Asp Pro Ala His Ile Ala Glu Arg His 
                245                 250                 255     


Gly His Lys Glu Leu Lys Lys Ile Phe Glu Asp Phe Ser Ile Gln Glu 
            260                 265                 270         


Ile Asp Ile Asn Asn Glu Gln Glu Asn Asp Tyr Glu Glu Asp Ile Ala 
        275                 280                 285             


Ser Phe Ser Xaa Tyr Ile Pro Ser Xaa Gln Asn Pro Ala Phe His His 
    290                 295                 300                 


Glu Ser Arg Lys Xaa Tyr Gly Gln Ser Ala Asp Gly Ala Glu Ala Asn 
305                 310                 315                 320 


Glu Met Glu Gly Glu Gly Lys Gln Asn Gly Ser Gly Met Glu Xaa Lys 
                325                 330                 335     


His Ser Pro Leu Glu Val Gly Ser Glu Ser Ser Glu Asp Gln Tyr Asp 
            340                 345                 350         


Asp Leu Tyr Val Phe Ile Pro Gly Ala Asp Pro Glu Asn Asn Ser Gln 
        355                 360                 365             


Glu Pro Leu Met Ser Ser Arg Pro Pro Leu Pro Pro Pro Arg Pro Val 
    370                 375                 380                 


Ala Asn Ala Phe Gln Leu Glu Arg Pro His Phe Xaa Leu Pro Gly Xaa 
385                 390                 395                 400 


Met Val Glu Gly Gln Met Glu Arg Ser Gln Asn Trp Gly His Pro Gly 
                405                 410                 415     


Val Arg Gln Glu Xaa Gly Asp Glu Pro Lys Gly Glu Lys Glu Lys Lys 
            420                 425                 430         


Glu Glu Glu Lys Glu Gln Glu Glu Glu Glu Asp Pro Tyr Xaa Phe Ala 
        435                 440                 445             


Glu Ile Asp Asp Ser Glu Tyr Asp Met Ile Leu Ala Asn Leu Ser Ile 
    450                 455                 460                 


Lys Lys Lys Xaa Gly Ser Arg Ser Phe Ile Ile Asn Arg Pro Pro Ala 
465                 470                 475                 480 


Pro Xaa Pro Arg Pro Xaa Ser Ile Pro Pro Lys Glu Glu Xaa Xaa Pro 
                485                 490                 495     


Tyr Ile Ala Gln Val Phe Gln Gln Lys Xaa Ala Arg Arg Gln Ser Asp 
            500                 505                 510         


Asp Asp Lys Phe Cys Gly Leu Pro Lys Lys Gln Asp Arg Ala Arg Ile 
        515                 520                 525             


Glu Ser Pro Ala Phe Ser Xaa Leu Arg Gly Cys Leu Xaa Asp Gly Gln 
    530                 535                 540                 


Glu Glu Leu Ile Leu Leu Gln Glu Lys Val Lys Asn Gly Lys Met Ser 
545                 550                 555                 560 


Met Asp Glu Ala Leu Glu Lys Phe Lys His Trp Gln Met Gly Lys Ser 
                565                 570                 575     


Gly Leu Glu Met Ile Gln Gln Glu Lys Leu Arg Gln Leu Arg Asp Cys 
            580                 585                 590         


Ile Ile Gly Lys Arg Pro Glu Glu Glu Asn Val Tyr Asn Lys Leu Xaa 
        595                 600                 605             


Ile Val His His Pro Gly Gly Lys Glu Xaa Ala His Asn Glu Asn Lys 
    610                 615                 620                 


Phe Tyr Asn Val His Phe Ser Asn Lys Leu Pro Ala Arg Pro Gln Val 
625                 630                 635                 640 


Glu Lys Glu Phe Gly Phe Cys Cys Lys Lys Asp His 
                645                 650         


<210> 3901
<211> 785
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<400> 3901
Met Leu Pro Ala Ala Pro Gly Lys Gly Leu Gly Ser Pro Asp Pro Ala 
1               5                   10                  15      


Pro Cys Gly Pro Ala Pro Pro Gly Asn Xaa Lys Asp Ile Ile Met Ile 
            20                  25                  30          


Tyr Glu Glu Asp Ala Glu Glu Trp Ala Leu Tyr Leu Xaa Glu Val Phe 
        35                  40                  45              


Leu His Val Val Lys Arg Glu Ala Ile Leu Leu Tyr Arg Leu Glu Asn 
    50                  55                  60                  


Phe Ser Phe Arg His Leu Glu Leu Leu Asn Leu Xaa Ser Tyr Lys Cys 
65                  70                  75                  80  


Lys Leu Leu Ile Leu Ser Asn Ser Leu Leu Arg Asp Leu Xaa Pro Lys 
                85                  90                  95      


Lys Cys Gln Phe Leu Glu Lys Ile Leu His Ser Pro Lys Ser Val Val 
            100                 105                 110         


Xaa Leu Leu Cys Gly Val Lys Ser Ser Asp Gln Leu Tyr Glu Leu Leu 
        115                 120                 125             


Asn Ile Ser Gln Ser Arg Trp Glu Ile Ser Xaa Glu Gln Glu Pro Glu 
    130                 135                 140                 


Asp Tyr Ile Ser Val Ile Gln Ser Ile Ile Phe Lys Asp Ser Glu Asp 
145                 150                 155                 160 


Tyr Phe Glu Val Asn Ile Pro Xaa Asp Leu Arg Ala Lys His Ser Gly 
                165                 170                 175     


Glu Ile Ser Glu Arg Lys Glu Ile Glu Glu Leu Ser Glu Ala Ser Arg 
            180                 185                 190         


Asn Xaa Ile Pro Leu Ala Val Val Leu Pro Xaa Glu Ile Pro Cys Glu 
        195                 200                 205             


Asn Pro Gly Glu Ile Phe Ile Ile Leu Arg Asp Glu Val Ile Gly Asp 
    210                 215                 220                 


Xaa Val Glu Val Glu Phe Xaa Ser Ser Asn Lys Arg Ile Arg Xaa Arg 
225                 230                 235                 240 


Pro Ala Leu Trp Asn Lys Lys Val Trp Cys Met Lys Ala Leu Glu Phe 
                245                 250                 255     


Pro Ala Gly Ser Val His Val Asn Val Tyr Cys Asp Gly Ile Val Lys 
            260                 265                 270         


Ala Xaa Xaa Lys Ile Lys Tyr Tyr Pro Xaa Ala Lys Ala Lys Glu Cys 
        275                 280                 285             


Leu Phe Arg Met Ala Asp Ser Gly Glu Ser Leu Cys Gln Asn Ser Ile 
    290                 295                 300                 


Glu Glu Leu Asp Gly Val Leu Xaa Ser Ile Phe Lys His Glu Ile Pro 
305                 310                 315                 320 


Tyr Tyr Glu Phe Gln Ser Leu Gln Xaa Glu Ile Cys Ser Gln Asn Lys 
                325                 330                 335     


Tyr Xaa His Phe Lys Glu Leu Pro Xaa Leu Leu His Cys Ala Ala Lys 
            340                 345                 350         


Phe Gly Leu Lys Asn Leu Ala Ile His Leu Leu Gln Cys Ser Gly Ala 
        355                 360                 365             


Xaa Trp Ala Ser Lys Met Lys Asn Met Glu Gly Ser Asp Pro Ala His 
    370                 375                 380                 


Ile Ala Glu Arg His Gly His Lys Glu Leu Lys Lys Ile Phe Glu Asp 
385                 390                 395                 400 


Phe Ser Ile Gln Glu Ile Asp Ile Asn Asn Glu Gln Glu Asn Asp Tyr 
                405                 410                 415     


Glu Glu Asp Ile Ala Ser Phe Ser Xaa Tyr Ile Pro Ser Xaa Gln Asn 
            420                 425                 430         


Pro Ala Phe His His Glu Ser Arg Lys Xaa Tyr Gly Gln Ser Ala Asp 
        435                 440                 445             


Gly Ala Glu Ala Asn Glu Met Glu Gly Glu Gly Lys Gln Asn Gly Ser 
    450                 455                 460                 


Gly Met Glu Xaa Lys His Ser Pro Leu Glu Val Gly Ser Glu Ser Ser 
465                 470                 475                 480 


Glu Asp Gln Tyr Asp Asp Leu Tyr Val Phe Ile Pro Gly Ala Asp Pro 
                485                 490                 495     


Glu Asn Asn Ser Gln Glu Pro Leu Met Ser Ser Arg Pro Pro Leu Pro 
            500                 505                 510         


Pro Pro Arg Pro Val Ala Asn Ala Phe Gln Leu Glu Arg Pro His Phe 
        515                 520                 525             


Xaa Leu Pro Gly Xaa Met Val Glu Gly Gln Met Glu Arg Ser Gln Asn 
    530                 535                 540                 


Trp Gly His Pro Gly Val Arg Gln Glu Xaa Gly Asp Glu Pro Lys Gly 
545                 550                 555                 560 


Glu Lys Glu Lys Lys Glu Glu Glu Lys Glu Gln Glu Glu Glu Glu Asp 
                565                 570                 575     


Pro Tyr Xaa Phe Ala Glu Ile Asp Asp Ser Glu Tyr Asp Met Ile Leu 
            580                 585                 590         


Ala Asn Leu Ser Ile Lys Lys Lys Xaa Gly Ser Arg Ser Phe Ile Ile 
        595                 600                 605             


Asn Arg Pro Pro Ala Pro Xaa Pro Arg Pro Xaa Ser Ile Pro Pro Lys 
    610                 615                 620                 


Glu Glu Xaa Xaa Pro Tyr Ile Ala Gln Val Phe Gln Gln Lys Xaa Ala 
625                 630                 635                 640 


Arg Arg Gln Ser Asp Asp Asp Lys Phe Cys Gly Leu Pro Lys Lys Gln 
                645                 650                 655     


Asp Arg Ala Arg Ile Glu Ser Pro Ala Phe Ser Xaa Leu Arg Gly Cys 
            660                 665                 670         


Leu Xaa Asp Gly Gln Glu Glu Leu Ile Leu Leu Gln Glu Lys Val Lys 
        675                 680                 685             


Asn Gly Lys Met Ser Met Asp Glu Ala Leu Glu Lys Phe Lys His Trp 
    690                 695                 700                 


Gln Met Gly Lys Ser Gly Leu Glu Met Ile Gln Gln Glu Lys Leu Arg 
705                 710                 715                 720 


Gln Leu Arg Asp Cys Ile Ile Gly Lys Arg Pro Glu Glu Glu Asn Val 
                725                 730                 735     


Tyr Asn Lys Leu Xaa Ile Val His His Pro Gly Gly Lys Glu Xaa Ala 
            740                 745                 750         


His Asn Glu Asn Lys Phe Tyr Asn Val His Phe Ser Asn Lys Leu Pro 
        755                 760                 765             


Ala Arg Pro Gln Val Glu Lys Glu Phe Gly Phe Cys Cys Lys Lys Asp 
    770                 775                 780                 


His 
785 


<210> 3902
<211> 770
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<400> 3902
Met Val Asn Cys His Leu Lys Ile Gly Asn Xaa Lys Asp Ile Ile Met 
1               5                   10                  15      


Ile Tyr Glu Glu Asp Ala Glu Glu Trp Ala Leu Tyr Leu Xaa Glu Val 
            20                  25                  30          


Phe Leu His Val Val Lys Arg Glu Ala Ile Leu Leu Tyr Arg Leu Glu 
        35                  40                  45              


Asn Phe Ser Phe Arg His Leu Glu Leu Leu Asn Leu Xaa Ser Tyr Lys 
    50                  55                  60                  


Cys Lys Leu Leu Ile Leu Ser Asn Ser Leu Leu Arg Asp Leu Xaa Pro 
65                  70                  75                  80  


Lys Lys Cys Gln Phe Leu Glu Lys Ile Leu His Ser Pro Lys Ser Val 
                85                  90                  95      


Val Xaa Leu Leu Cys Gly Val Lys Ser Ser Asp Gln Leu Tyr Glu Leu 
            100                 105                 110         


Leu Asn Ile Ser Gln Ser Arg Trp Glu Ile Ser Xaa Glu Gln Glu Pro 
        115                 120                 125             


Glu Asp Tyr Ile Ser Val Ile Gln Ser Ile Ile Phe Lys Asp Ser Glu 
    130                 135                 140                 


Asp Tyr Phe Glu Val Asn Ile Pro Xaa Asp Leu Arg Ala Lys His Ser 
145                 150                 155                 160 


Gly Glu Ile Ser Glu Arg Lys Glu Ile Glu Glu Leu Ser Glu Ala Ser 
                165                 170                 175     


Arg Asn Xaa Ile Pro Leu Ala Val Val Leu Pro Xaa Glu Ile Pro Cys 
            180                 185                 190         


Glu Asn Pro Gly Glu Ile Phe Ile Ile Leu Arg Asp Glu Val Ile Gly 
        195                 200                 205             


Asp Xaa Val Glu Val Glu Phe Xaa Ser Ser Asn Lys Arg Ile Arg Xaa 
    210                 215                 220                 


Arg Pro Ala Leu Trp Asn Lys Lys Val Trp Cys Met Lys Ala Leu Glu 
225                 230                 235                 240 


Phe Pro Ala Gly Ser Val His Val Asn Val Tyr Cys Asp Gly Ile Val 
                245                 250                 255     


Lys Ala Xaa Xaa Lys Ile Lys Tyr Tyr Pro Xaa Ala Lys Ala Lys Glu 
            260                 265                 270         


Cys Leu Phe Arg Met Ala Asp Ser Gly Glu Ser Leu Cys Gln Asn Ser 
        275                 280                 285             


Ile Glu Glu Leu Asp Gly Val Leu Xaa Ser Ile Phe Lys His Glu Ile 
    290                 295                 300                 


Pro Tyr Tyr Glu Phe Gln Ser Leu Gln Xaa Glu Ile Cys Ser Gln Asn 
305                 310                 315                 320 


Lys Tyr Xaa His Phe Lys Glu Leu Pro Xaa Leu Leu His Cys Ala Ala 
                325                 330                 335     


Lys Phe Gly Leu Lys Asn Leu Ala Ile His Leu Leu Gln Cys Ser Gly 
            340                 345                 350         


Ala Xaa Trp Ala Ser Lys Met Lys Asn Met Glu Gly Ser Asp Pro Ala 
        355                 360                 365             


His Ile Ala Glu Arg His Gly His Lys Glu Leu Lys Lys Ile Phe Glu 
    370                 375                 380                 


Asp Phe Ser Ile Gln Glu Ile Asp Ile Asn Asn Glu Gln Glu Asn Asp 
385                 390                 395                 400 


Tyr Glu Glu Asp Ile Ala Ser Phe Ser Xaa Tyr Ile Pro Ser Xaa Gln 
                405                 410                 415     


Asn Pro Ala Phe His His Glu Ser Arg Lys Xaa Tyr Gly Gln Ser Ala 
            420                 425                 430         


Asp Gly Ala Glu Ala Asn Glu Met Glu Gly Glu Gly Lys Gln Asn Gly 
        435                 440                 445             


Ser Gly Met Glu Xaa Lys His Ser Pro Leu Glu Val Gly Ser Glu Ser 
    450                 455                 460                 


Ser Glu Asp Gln Tyr Asp Asp Leu Tyr Val Phe Ile Pro Gly Ala Asp 
465                 470                 475                 480 


Pro Glu Asn Asn Ser Gln Glu Pro Leu Met Ser Ser Arg Pro Pro Leu 
                485                 490                 495     


Pro Pro Pro Arg Pro Val Ala Asn Ala Phe Gln Leu Glu Arg Pro His 
            500                 505                 510         


Phe Xaa Leu Pro Gly Xaa Met Val Glu Gly Gln Met Glu Arg Ser Gln 
        515                 520                 525             


Asn Trp Gly His Pro Gly Val Arg Gln Glu Xaa Gly Asp Glu Pro Lys 
    530                 535                 540                 


Gly Glu Lys Glu Lys Lys Glu Glu Glu Lys Glu Gln Glu Glu Glu Glu 
545                 550                 555                 560 


Asp Pro Tyr Xaa Phe Ala Glu Ile Asp Asp Ser Glu Tyr Asp Met Ile 
                565                 570                 575     


Leu Ala Asn Leu Ser Ile Lys Lys Lys Xaa Gly Ser Arg Ser Phe Ile 
            580                 585                 590         


Ile Asn Arg Pro Pro Ala Pro Xaa Pro Arg Pro Xaa Ser Ile Pro Pro 
        595                 600                 605             


Lys Glu Glu Xaa Xaa Pro Tyr Ile Ala Gln Val Phe Gln Gln Lys Xaa 
    610                 615                 620                 


Ala Arg Arg Gln Ser Asp Asp Asp Lys Phe Cys Gly Leu Pro Lys Lys 
625                 630                 635                 640 


Gln Asp Arg Ala Arg Ile Glu Ser Pro Ala Phe Ser Xaa Leu Arg Gly 
                645                 650                 655     


Cys Leu Xaa Asp Gly Gln Glu Glu Leu Ile Leu Leu Gln Glu Lys Val 
            660                 665                 670         


Lys Asn Gly Lys Met Ser Met Asp Glu Ala Leu Glu Lys Phe Lys His 
        675                 680                 685             


Trp Gln Met Gly Lys Ser Gly Leu Glu Met Ile Gln Gln Glu Lys Leu 
    690                 695                 700                 


Arg Gln Leu Arg Asp Cys Ile Ile Gly Lys Arg Pro Glu Glu Glu Asn 
705                 710                 715                 720 


Val Tyr Asn Lys Leu Xaa Ile Val His His Pro Gly Gly Lys Glu Xaa 
                725                 730                 735     


Ala His Asn Glu Asn Lys Phe Tyr Asn Val His Phe Ser Asn Lys Leu 
            740                 745                 750         


Pro Ala Arg Pro Gln Val Glu Lys Glu Phe Gly Phe Cys Cys Lys Lys 
        755                 760                 765             


Asp His 
    770 


<210> 3903
<211> 195
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<400> 3903
Met Met Ser Glu His Asp Leu Ala Asp Val Val Gln Ile Ala Val Glu 
1               5                   10                  15      


Asp Leu Ser Pro Asp His Pro Gly Xaa Glu Leu Trp Asp Ile Val Leu 
            20                  25                  30          


Glu Asn His Val Val Xaa Asp Glu Asp Glu Pro Ala Leu Lys Arg Gln 
        35                  40                  45              


Arg Leu Glu Ile Asn Cys Gln Asp Pro Ser Ile Lys Ser Phe Leu Tyr 
    50                  55                  60                  


Ser Ile Asn Gln Xaa Ile Cys Leu Arg Leu Asp Ser Ile Glu Ala Lys 
65                  70                  75                  80  


Leu Gln Ala Leu Glu Ala Xaa Cys Lys Ser Leu Glu Glu Lys Leu Asp 
                85                  90                  95      


Leu Val Xaa Asn Lys Gln His Ser Pro Ile Gln Val Pro Met Val Ala 
            100                 105                 110         


Gly Ser Pro Leu Gly Ala Xaa Gln Xaa Cys Asn Lys Val Arg Cys Ala 
        115                 120                 125             


Val Pro Gly Arg Arg Gln Asn Xaa Ile Val Val Lys Val Pro Gly Gln 
    130                 135                 140                 


Glu Asp Ser His His Glu Asp Gly Glu Ser Gly Ser Glu Ala Ser Asp 
145                 150                 155                 160 


Ser Val Ser Ser Cys Gly Gln Ala Gly Ser Gln Ser Ile Gly Ser Asn 
                165                 170                 175     


Val Xaa Leu Ile Xaa Leu Asn Ser Glu Glu Asp Tyr Pro Asn Gly Xaa 
            180                 185                 190         


Trp Leu Gly 
        195 


<210> 3904
<211> 497
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<400> 3904
Met Met Ser Glu His Asp Leu Ala Asp Val Val Gln Ile Ala Val Glu 
1               5                   10                  15      


Asp Leu Ser Pro Asp His Pro Gly Xaa Glu Leu Trp Asp Ile Val Leu 
            20                  25                  30          


Glu Asn His Val Val Xaa Asp Glu Asp Glu Pro Ala Leu Lys Arg Gln 
        35                  40                  45              


Arg Leu Glu Ile Asn Cys Gln Asp Pro Ser Ile Lys Ser Phe Leu Tyr 
    50                  55                  60                  


Ser Ile Asn Gln Xaa Ile Cys Leu Arg Leu Asp Ser Ile Glu Ala Lys 
65                  70                  75                  80  


Leu Gln Ala Leu Glu Ala Xaa Cys Lys Ser Leu Glu Glu Lys Leu Asp 
                85                  90                  95      


Leu Val Xaa Asn Lys Gln His Ser Pro Ile Gln Val Pro Met Val Ala 
            100                 105                 110         


Gly Ser Pro Leu Gly Ala Xaa Gln Xaa Cys Asn Lys Val Arg Cys Ala 
        115                 120                 125             


Val Pro Gly Arg Arg Gln Asn Xaa Ile Val Val Lys Val Pro Gly Gln 
    130                 135                 140                 


Glu Asp Ser His His Glu Asp Gly Glu Ser Gly Ser Glu Ala Ser Asp 
145                 150                 155                 160 


Ser Val Ser Ser Cys Gly Gln Ala Gly Ser Gln Ser Ile Gly Ser Asn 
                165                 170                 175     


Val Xaa Leu Ile Xaa Leu Asn Ser Glu Glu Asp Tyr Pro Asn Gly Xaa 
            180                 185                 190         


Trp Leu Gly Asp Glu Asn Asn Pro Glu Met Arg Val Arg Cys Ala Ile 
        195                 200                 205             


Ile Pro Ser Asp Met Leu His Ile Ser Xaa Asn Cys Arg Xaa Ala Glu 
    210                 215                 220                 


Lys Met Ala Leu Xaa Leu Leu Asp Tyr Leu Phe His Arg Glu Val Gln 
225                 230                 235                 240 


Ala Val Ser Asn Leu Ser Gly Gln Gly Lys His Gly Lys Lys Gln Leu 
                245                 250                 255     


Asp Pro Leu Xaa Ile Tyr Gly Ile Arg Cys His Leu Phe Tyr Lys Phe 
            260                 265                 270         


Gly Ile Xaa Glu Ser Asp Trp Tyr Arg Ile Lys Gln Ser Ile Asp Ser 
        275                 280                 285             


Lys Cys Arg Xaa Ala Trp Arg Arg Lys Gln Arg Gly Gln Ser Leu Ala 
    290                 295                 300                 


Val Lys Ser Phe Ser Arg Arg Xaa Pro Asn Ser Ser Ser Tyr Cys Pro 
305                 310                 315                 320 


Ser Glu Pro Met Met Ser Xaa Pro Pro Pro Ala Ser Glu Leu Pro Gln 
                325                 330                 335     


Pro Gln Pro Gln Pro Gln Ala Leu His Tyr Ala Leu Ala Asn Ala Gln 
            340                 345                 350         


Gln Val Gln Ile His Gln Ile Gly Glu Asp Gly Gln Val Gln Val Ile 
        355                 360                 365             


Pro Gln Gly His Leu His Ile Ala Gln Val Pro Gln Gly Glu Gln Val 
    370                 375                 380                 


Gln Ile Xaa Gln Asp Ser Glu Gly Asn Leu Gln Ile His His Val Gly 
385                 390                 395                 400 


Gln Asp Gly Gln Leu Leu Glu Ala Xaa Arg Ile Pro Cys Leu Leu Ala 
                405                 410                 415     


Pro Ser Val Phe Lys Ala Ser Ser Gly Gln Val Leu Gln Gly Ala Gln 
            420                 425                 430         


Leu Ile Ala Val Ala Ser Ser Asp Pro Ala Ala Ala Gly Val Asp Gly 
        435                 440                 445             


Ser Pro Leu Gln Gly Ser Asp Ile Gln Val Gln Tyr Val Gln Leu Ala 
    450                 455                 460                 


Pro Val Ser Asp His Xaa Ala Gly Ala Gln Xaa Ala Glu Ala Leu Gln 
465                 470                 475                 480 


Pro Xaa Leu Gln Pro Glu Met Gln Leu Glu His Gly Ala Ile Gln Ile 
                485                 490                 495     


Gln 
    


<210> 3905
<211> 40
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<400> 3905
Met Met Ser Glu His Asp Leu Ala Asp Val Val Gln Ile Ala Val Glu 
1               5                   10                  15      


Asp Leu Ser Pro Asp His Pro Gly Xaa Glu Leu Trp Asp Ser Ser Cys 
            20                  25                  30          


Phe Gly Glu Ser Cys Ser Asp Arg 
        35                  40  


<210> 3906
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3906
Met Met Ser Glu His Asp Leu Ala Asp Val Val Gln Ile Ala Val Glu 
1               5                   10                  15      


Asp Leu Ser Pro Asp His Pro Val Val Leu Glu Asn 
            20                  25              


<210> 3907
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<400> 3907
Met Met Ser Glu His Asp Leu Ala Asp Val Val Gln Ile Ala Val Glu 
1               5                   10                  15      


Asp Leu Ser Pro Asp His Pro Val Val Leu Glu Asn His Val Val Xaa 
            20                  25                  30          


Asp Glu Asp Glu Pro Ala Leu Lys Arg Gln Arg Leu Glu Ile Asn Cys 
        35                  40                  45              


Gln Asp Pro Ser Ile Lys Ser Phe Leu Tyr Ser Ile Asn Gln Xaa Ile 
    50                  55                  60                  


Cys Leu Arg Leu Asp Ser Ile Glu Ala Lys Leu Gln Ala Leu Glu Ala 
65                  70                  75                  80  


Xaa Cys Lys Ser Leu Glu Glu Lys Leu Asp Leu Val Xaa Asn Lys 
                85                  90                  95  


<210> 3908
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 3908
Met Met Ser Glu His Asp Leu Ala Asp Val Val Gln Ile Ala Val Glu 
1               5                   10                  15      


Asp Leu Ser Pro Asp His Pro Val Val Leu Glu Asn His Val Val Xaa 
            20                  25                  30          


Asp Glu Asp Glu Pro Ala Leu Lys Arg Gln Arg Leu Glu Ile Asn Cys 
        35                  40                  45              


Gln Asp Pro Ser Ile Lys Ser Phe Leu Tyr Ser Ile Asn Gln Xaa Ile 
    50                  55                  60                  


Cys Leu Arg Leu Asp Ser Ile Glu Ala Lys Leu Gln Ala Leu Glu Ala 
65                  70                  75                  80  


Xaa Cys Lys Ser Leu Glu Glu Lys Leu Asp Leu Val Xaa Asn Lys Gln 
                85                  90                  95      


His Ser Pro Ile Gln Val Pro Met Val Ala Gly Ser Pro Leu Gly Ala 
            100                 105                 110         


Xaa Gln Xaa Cys Asn Lys 
        115             


<210> 3909
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 3909
Met Met Ser Glu His Asp Leu Ala Asp Val Val Gln Ile Ala Val Glu 
1               5                   10                  15      


Asp Leu Ser Pro Asp His Pro Val Val Leu Glu Asn His Val Val Xaa 
            20                  25                  30          


Asp Glu Asp Glu Pro Ala Leu Lys Arg Gln Arg Leu Glu Ile Asn Cys 
        35                  40                  45              


Gln Asp Pro Ser Ile Lys Ser Phe Leu Tyr Ser Ile Asn Gln Xaa Ile 
    50                  55                  60                  


Cys Leu Arg Leu Asp Ser Ile Glu Ala Lys Leu Gln Ala Leu Glu Ala 
65                  70                  75                  80  


Xaa Cys Lys Ser Leu Glu Glu Lys Leu Asp Leu Val Xaa Asn Lys Gln 
                85                  90                  95      


His Ser Pro Ile Gln Val Pro Met Val Ala Gly Ser Pro Leu Gly Ala 
            100                 105                 110         


Xaa Gln Xaa Cys Asn Lys Val 
        115                 


<210> 3910
<211> 466
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<400> 3910
Met Met Ser Glu His Asp Leu Ala Asp Val Val Gln Ile Ala Val Glu 
1               5                   10                  15      


Asp Leu Ser Pro Asp His Pro Val Val Leu Glu Asn His Val Val Xaa 
            20                  25                  30          


Asp Glu Asp Glu Pro Ala Leu Lys Arg Gln Arg Leu Glu Ile Asn Cys 
        35                  40                  45              


Gln Asp Pro Ser Ile Lys Ser Phe Leu Tyr Ser Ile Asn Gln Xaa Ile 
    50                  55                  60                  


Cys Leu Arg Leu Asp Ser Ile Glu Ala Lys Leu Gln Ala Leu Glu Ala 
65                  70                  75                  80  


Xaa Cys Lys Ser Leu Glu Glu Lys Leu Asp Leu Val Xaa Asn Lys Gln 
                85                  90                  95      


His Ser Pro Ile Gln Val Pro Met Val Ala Gly Ser Pro Leu Gly Ala 
            100                 105                 110         


Xaa Gln Xaa Cys Asn Lys Val Arg Cys Ala Val Pro Gly Arg Arg Gln 
        115                 120                 125             


Asn Xaa Ile Val Val Lys Val Pro Gly Gln Glu Asp Ser His His Glu 
    130                 135                 140                 


Asp Gly Glu Ser Gly Ser Glu Ala Ser Asp Ser Val Ser Ser Cys Gly 
145                 150                 155                 160 


Gln Ala Gly Ser Gln Ser Ile Gly Ser Asn Val Xaa Leu Ile Xaa Leu 
                165                 170                 175     


Asn Ser Glu Glu Asp Tyr Pro Asn Gly Xaa Trp Leu Gly Asp Glu Asn 
            180                 185                 190         


Asn Pro Glu Met Arg Val Arg Cys Ala Ile Ile Pro Ser Asp Met Leu 
        195                 200                 205             


His Ile Ser Xaa Asn Cys Arg Xaa Ala Glu Lys Met Ala Leu Xaa Leu 
    210                 215                 220                 


Leu Asp Tyr Leu Phe His Arg Glu Val Gln Ala Val Ser Asn Leu Ser 
225                 230                 235                 240 


Gly Gln Gly Lys His Gly Lys Lys Gln Leu Asp Pro Leu Xaa Ile Tyr 
                245                 250                 255     


Gly Ile Arg Cys His Leu Phe Tyr Lys Phe Gly Ile Xaa Glu Ser Asp 
            260                 265                 270         


Trp Tyr Arg Ile Lys Gln Ser Ile Asp Ser Lys Cys Arg Xaa Ala Trp 
        275                 280                 285             


Arg Arg Lys Gln Arg Gly Gln Ser Leu Ala Val Lys Ser Phe Ser Arg 
    290                 295                 300                 


Arg Xaa Pro Asn Ser Ser Ser Tyr Cys Pro Ser Glu Pro Met Met Ser 
305                 310                 315                 320 


Xaa Pro Pro Pro Ala Ser Glu Leu Pro Gln Pro Gln Pro Gln Pro Gln 
                325                 330                 335     


Ala Leu His Tyr Ala Leu Ala Asn Ala Gln Gln Val Gln Ile His Gln 
            340                 345                 350         


Ile Gly Glu Asp Gly Gln Val Gln Val Gly His Leu His Ile Ala Gln 
        355                 360                 365             


Val Pro Gln Gly Glu Gln Val Gln Ile Xaa Gln Asp Ser Glu Gly Asn 
    370                 375                 380                 


Leu Gln Ile His His Val Gly Gln Asp Gly Gln Val Leu Gln Gly Ala 
385                 390                 395                 400 


Gln Leu Ile Ala Val Ala Ser Ser Asp Pro Ala Ala Ala Gly Val Asp 
                405                 410                 415     


Gly Ser Pro Leu Gln Gly Ser Asp Ile Gln Val Gln Tyr Val Gln Leu 
            420                 425                 430         


Ala Pro Val Ser Asp His Xaa Ala Gly Ala Gln Xaa Ala Glu Ala Leu 
        435                 440                 445             


Gln Pro Xaa Leu Gln Pro Glu Met Gln Leu Glu His Gly Ala Ile Gln 
    450                 455                 460                 


Ile Gln 
465     


<210> 3911
<211> 469
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<400> 3911
Met Met Ser Glu His Asp Leu Ala Asp Val Val Gln Ile Ala Val Glu 
1               5                   10                  15      


Asp Leu Ser Pro Asp His Pro Val Val Leu Glu Asn His Val Val Xaa 
            20                  25                  30          


Asp Glu Asp Glu Pro Ala Leu Lys Arg Gln Arg Leu Glu Ile Asn Cys 
        35                  40                  45              


Gln Asp Pro Ser Ile Lys Ser Phe Leu Tyr Ser Ile Asn Gln Xaa Ile 
    50                  55                  60                  


Cys Leu Arg Leu Asp Ser Ile Glu Ala Lys Leu Gln Ala Leu Glu Ala 
65                  70                  75                  80  


Xaa Cys Lys Ser Leu Glu Glu Lys Leu Asp Leu Val Xaa Asn Lys Gln 
                85                  90                  95      


His Ser Pro Ile Gln Val Pro Met Val Ala Gly Ser Pro Leu Gly Ala 
            100                 105                 110         


Xaa Gln Xaa Cys Asn Lys Val Arg Cys Ala Val Pro Gly Arg Arg Gln 
        115                 120                 125             


Asn Xaa Ile Val Val Lys Val Pro Gly Gln Glu Asp Ser His His Glu 
    130                 135                 140                 


Asp Gly Glu Ser Gly Ser Glu Ala Ser Asp Ser Val Ser Ser Cys Gly 
145                 150                 155                 160 


Gln Ala Gly Ser Gln Ser Ile Gly Ser Asn Val Xaa Leu Ile Xaa Leu 
                165                 170                 175     


Asn Ser Glu Glu Asp Tyr Pro Asn Gly Xaa Trp Leu Gly Asp Glu Asn 
            180                 185                 190         


Asn Pro Glu Met Arg Val Arg Cys Ala Ile Ile Pro Ser Asp Met Leu 
        195                 200                 205             


His Ile Ser Xaa Asn Cys Arg Xaa Ala Glu Lys Met Ala Leu Xaa Leu 
    210                 215                 220                 


Leu Asp Tyr Leu Phe His Arg Glu Val Gln Ala Val Ser Asn Leu Ser 
225                 230                 235                 240 


Gly Gln Gly Lys His Gly Lys Lys Gln Leu Asp Pro Leu Xaa Ile Tyr 
                245                 250                 255     


Gly Ile Arg Cys His Leu Phe Tyr Lys Phe Gly Ile Xaa Glu Ser Asp 
            260                 265                 270         


Trp Tyr Arg Ile Lys Gln Ser Ile Asp Ser Lys Cys Arg Xaa Ala Trp 
        275                 280                 285             


Arg Arg Lys Gln Arg Gly Gln Ser Leu Ala Val Lys Ser Phe Ser Arg 
    290                 295                 300                 


Arg Xaa Pro Asn Ser Ser Ser Tyr Cys Pro Ser Glu Pro Met Met Ser 
305                 310                 315                 320 


Xaa Pro Pro Pro Ala Ser Glu Leu Pro Gln Pro Gln Pro Gln Pro Gln 
                325                 330                 335     


Ala Leu His Tyr Ala Leu Ala Asn Ala Gln Gln Val Gln Ile His Gln 
            340                 345                 350         


Ile Gly Glu Asp Gly Gln Val Gln Val Ile Pro Gln Gly His Leu His 
        355                 360                 365             


Ile Ala Gln Val Pro Gln Gly Glu Gln Val Gln Ile Xaa Gln Asp Ser 
    370                 375                 380                 


Glu Gly Asn Leu Gln Ile His His Val Gly Gln Asp Gly Gln Val Leu 
385                 390                 395                 400 


Gln Gly Ala Gln Leu Ile Ala Val Ala Ser Ser Asp Pro Ala Ala Ala 
                405                 410                 415     


Gly Val Asp Gly Ser Pro Leu Gln Gly Ser Asp Ile Gln Val Gln Tyr 
            420                 425                 430         


Val Gln Leu Ala Pro Val Ser Asp His Xaa Ala Gly Ala Gln Xaa Ala 
        435                 440                 445             


Glu Ala Leu Gln Pro Xaa Leu Gln Pro Glu Met Gln Leu Glu His Gly 
    450                 455                 460                 


Ala Ile Gln Ile Gln 
465                 


<210> 3912
<211> 491
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<400> 3912
Met Met Ser Glu His Asp Leu Ala Asp Val Val Gln Ile Ala Val Glu 
1               5                   10                  15      


Asp Leu Ser Pro Asp His Pro Val Val Leu Glu Asn His Val Val Xaa 
            20                  25                  30          


Asp Glu Asp Glu Pro Ala Leu Lys Arg Gln Arg Leu Glu Ile Asn Cys 
        35                  40                  45              


Gln Asp Pro Ser Ile Lys Ser Phe Leu Tyr Ser Ile Asn Gln Xaa Ile 
    50                  55                  60                  


Cys Leu Arg Leu Asp Ser Ile Glu Ala Lys Leu Gln Ala Leu Glu Ala 
65                  70                  75                  80  


Xaa Cys Lys Ser Leu Glu Glu Lys Leu Asp Leu Val Xaa Asn Lys Gln 
                85                  90                  95      


His Ser Pro Ile Gln Val Pro Met Val Ala Gly Ser Pro Leu Gly Ala 
            100                 105                 110         


Xaa Gln Xaa Cys Asn Lys Val Arg Cys Ala Val Pro Gly Arg Arg Gln 
        115                 120                 125             


Asn Xaa Ile Val Val Lys Val Pro Gly Gln Glu Asp Ser His His Glu 
    130                 135                 140                 


Asp Gly Glu Ser Gly Ser Glu Ala Ser Asp Ser Val Ser Ser Cys Gly 
145                 150                 155                 160 


Gln Ala Gly Ser Gln Ser Ile Gly Ser Asn Val Xaa Leu Ile Xaa Leu 
                165                 170                 175     


Asn Ser Glu Glu Asp Tyr Pro Asn Gly Xaa Trp Leu Gly Asp Glu Asn 
            180                 185                 190         


Asn Pro Glu Met Arg Val Arg Cys Ala Ile Ile Pro Ser Asp Met Leu 
        195                 200                 205             


His Ile Ser Xaa Asn Cys Arg Xaa Ala Glu Lys Met Ala Leu Xaa Leu 
    210                 215                 220                 


Leu Asp Tyr Leu Phe His Arg Glu Val Gln Ala Val Ser Asn Leu Ser 
225                 230                 235                 240 


Gly Gln Gly Lys His Gly Lys Lys Gln Leu Asp Pro Leu Xaa Ile Tyr 
                245                 250                 255     


Gly Ile Arg Cys His Leu Phe Tyr Lys Phe Gly Ile Xaa Glu Ser Asp 
            260                 265                 270         


Trp Tyr Arg Ile Lys Gln Ser Ile Asp Ser Lys Cys Arg Xaa Ala Trp 
        275                 280                 285             


Arg Arg Lys Gln Arg Gly Gln Ser Leu Ala Val Lys Ser Phe Ser Arg 
    290                 295                 300                 


Arg Xaa Pro Asn Ser Ser Ser Tyr Cys Pro Ser Glu Pro Met Met Ser 
305                 310                 315                 320 


Xaa Pro Pro Pro Ala Ser Glu Leu Pro Gln Pro Gln Pro Gln Pro Gln 
                325                 330                 335     


Ala Leu His Tyr Ala Leu Ala Asn Ala Gln Gln Val Gln Ile His Gln 
            340                 345                 350         


Ile Gly Glu Asp Gly Gln Val Gln Val Ile Pro Gln Gly His Leu His 
        355                 360                 365             


Ile Ala Gln Val Pro Gln Gly Glu Gln Val Gln Ile Xaa Gln Asp Ser 
    370                 375                 380                 


Glu Gly Asn Leu Gln Ile His His Val Gly Gln Asp Gly Gln Leu Leu 
385                 390                 395                 400 


Glu Ala Xaa Arg Ile Pro Cys Leu Leu Ala Pro Ser Val Phe Lys Ala 
                405                 410                 415     


Ser Ser Gly Gln Val Leu Gln Gly Ala Gln Leu Ile Ala Val Ala Ser 
            420                 425                 430         


Ser Asp Pro Ala Ala Ala Gly Val Asp Gly Ser Pro Leu Gln Gly Ser 
        435                 440                 445             


Asp Ile Gln Val Gln Tyr Val Gln Leu Ala Pro Val Ser Asp His Xaa 
    450                 455                 460                 


Ala Gly Ala Gln Xaa Ala Glu Ala Leu Gln Pro Xaa Leu Gln Pro Glu 
465                 470                 475                 480 


Met Gln Leu Glu His Gly Ala Ile Gln Ile Gln 
                485                 490     


<210> 3913
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 3913
Met Met Ser Glu His Asp Leu Ala Asp Val Val Gln Ile Ala Val Glu 
1               5                   10                  15      


Asp Leu Ser Pro Asp His Pro Val Val Leu Glu Asn His Val Val Xaa 
            20                  25                  30          


Asp Glu Asp Glu Pro Ala Leu Lys Arg Gln Arg Leu Glu Ile Asn Cys 
        35                  40                  45              


Gln Asp Pro Ser Ile Lys Ser Phe Leu Tyr Ser Ile Asn Gln Xaa Ile 
    50                  55                  60                  


Cys Leu Arg Leu Asp Ser Ile Glu Ala Lys Leu Gln Ala Leu Glu Ala 
65                  70                  75                  80  


Xaa Cys Lys Ser Leu Glu Glu Lys Leu Asp Leu Val Xaa Asn Lys Gln 
                85                  90                  95      


His Ser Pro Ile Gln Val Pro Met Val Ala Gly Ser Pro Leu Gly Ala 
            100                 105                 110         


Xaa Gln Xaa Cys Asn Lys Val Arg Cys Leu Pro Gln Gln Ser Gly Pro 
        115                 120                 125             


<210> 3914
<211> 123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 3914
Met Met Ser Glu His Asp Leu Ala Asp Val Val Gln Ile Ala Val Glu 
1               5                   10                  15      


Asp Leu Ser Pro Asp His Pro Val Val Leu Glu Asn His Val Val Xaa 
            20                  25                  30          


Asp Glu Asp Glu Pro Ala Leu Lys Arg Gln Arg Leu Glu Ile Asn Cys 
        35                  40                  45              


Gln Asp Pro Ser Ile Lys Ser Phe Leu Tyr Ser Ile Asn Gln Xaa Ile 
    50                  55                  60                  


Cys Leu Arg Leu Asp Ser Ile Glu Ala Lys Leu Gln Ala Leu Glu Ala 
65                  70                  75                  80  


Xaa Cys Lys Ser Leu Glu Glu Lys Leu Asp Leu Val Xaa Asn Lys Gln 
                85                  90                  95      


His Ser Pro Ile Gln Val Pro Met Val Ala Gly Ser Pro Leu Gly Ala 
            100                 105                 110         


Xaa Gln Xaa Cys Asn Lys Val Arg Cys Val Val 
        115                 120             


<210> 3915
<211> 508
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<400> 3915
Met Met Ser Glu His Asp Leu Ala Asp Val Val Gln Ile Ala Val Glu 
1               5                   10                  15      


Asp Leu Ser Pro Asp His Pro Val Val Leu Glu Asn His Val Val Xaa 
            20                  25                  30          


Asp Glu Asp Glu Pro Ala Leu Lys Arg Gln Arg Leu Glu Ile Asn Cys 
        35                  40                  45              


Gln Asp Pro Ser Ile Lys Ser Phe Leu Tyr Ser Ile Asn Gln Xaa Ile 
    50                  55                  60                  


Cys Leu Arg Leu Asp Ser Ile Glu Ala Lys Leu Gln Ala Leu Glu Ala 
65                  70                  75                  80  


Xaa Cys Lys Ser Leu Glu Glu Lys Leu Asp Leu Val Xaa Asn Lys Gln 
                85                  90                  95      


His Ser Pro Ile Gln Val Pro Met Val Ala Gly Ser Pro Leu Gly Ala 
            100                 105                 110         


Xaa Gln Xaa Cys Asn Lys Val Arg Cys Val Val Pro Gln Xaa Xaa Val 
        115                 120                 125             


Ile Leu Asn Asn Asp Arg Gln Asn Ala Ile Val Ala Lys Met Glu Asp 
    130                 135                 140                 


Pro Leu Ser Asn Arg Ala Pro Asp Ser Leu Glu Asn Val Ile Ser Asn 
145                 150                 155                 160 


Ala Val Pro Gly Arg Arg Gln Asn Xaa Ile Val Val Lys Val Pro Gly 
                165                 170                 175     


Gln Glu Asp Ser His His Glu Asp Gly Glu Ser Gly Ser Glu Ala Ser 
            180                 185                 190         


Asp Ser Val Ser Ser Cys Gly Gln Ala Gly Ser Gln Ser Ile Gly Ser 
        195                 200                 205             


Asn Val Xaa Leu Ile Xaa Leu Asn Ser Glu Glu Asp Tyr Pro Asn Gly 
    210                 215                 220                 


Xaa Trp Leu Gly Asp Glu Asn Asn Pro Glu Met Arg Val Arg Cys Ala 
225                 230                 235                 240 


Ile Ile Pro Ser Asp Met Leu His Ile Ser Xaa Asn Cys Arg Xaa Ala 
                245                 250                 255     


Glu Lys Met Ala Leu Xaa Leu Leu Asp Tyr Leu Phe His Arg Glu Val 
            260                 265                 270         


Gln Ala Val Ser Asn Leu Ser Gly Gln Gly Lys His Gly Lys Lys Gln 
        275                 280                 285             


Leu Asp Pro Leu Xaa Ile Tyr Gly Ile Arg Cys His Leu Phe Tyr Lys 
    290                 295                 300                 


Phe Gly Ile Xaa Glu Ser Asp Trp Tyr Arg Ile Lys Gln Ser Ile Asp 
305                 310                 315                 320 


Ser Lys Cys Arg Xaa Ala Trp Arg Arg Lys Gln Arg Gly Gln Ser Leu 
                325                 330                 335     


Ala Val Lys Ser Phe Ser Arg Arg Xaa Pro Asn Ser Ser Ser Tyr Cys 
            340                 345                 350         


Pro Ser Glu Pro Met Met Ser Xaa Pro Pro Pro Ala Ser Glu Leu Pro 
        355                 360                 365             


Gln Pro Gln Pro Gln Pro Gln Ala Leu His Tyr Ala Leu Ala Asn Ala 
    370                 375                 380                 


Gln Gln Val Gln Ile His Gln Ile Gly Glu Asp Gly Gln Val Gln Val 
385                 390                 395                 400 


Ile Pro Gln Gly His Leu His Ile Ala Gln Val Pro Gln Gly Glu Gln 
                405                 410                 415     


Val Gln Ile Xaa Gln Asp Ser Glu Gly Asn Leu Gln Ile His His Val 
            420                 425                 430         


Gly Gln Asp Gly Gln Val Leu Gln Gly Ala Gln Leu Ile Ala Val Ala 
        435                 440                 445             


Ser Ser Asp Pro Ala Ala Ala Gly Val Asp Gly Ser Pro Leu Gln Gly 
    450                 455                 460                 


Ser Asp Ile Gln Val Gln Tyr Val Gln Leu Ala Pro Val Ser Asp His 
465                 470                 475                 480 


Xaa Ala Gly Ala Gln Xaa Ala Glu Ala Leu Gln Pro Xaa Leu Gln Pro 
                485                 490                 495     


Glu Met Gln Leu Glu His Gly Ala Ile Gln Ile Gln 
            500                 505             


<210> 3916
<211> 519
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<400> 3916
Met Met Ser Glu His Asp Leu Ala Asp Val Val Gln Ile Ala Val Glu 
1               5                   10                  15      


Asp Leu Ser Pro Asp His Pro Val Val Leu Glu Asn His Val Val Xaa 
            20                  25                  30          


Asp Glu Asp Glu Pro Ala Leu Lys Arg Gln Arg Leu Glu Ile Asn Cys 
        35                  40                  45              


Gln Asp Pro Ser Ile Lys Xaa Ile Cys Leu Arg Leu Asp Ser Ile Glu 
    50                  55                  60                  


Ala Lys Leu Gln Ala Leu Glu Ala Xaa Cys Lys Ser Leu Glu Glu Lys 
65                  70                  75                  80  


Leu Asp Leu Val Xaa Asn Lys Gln His Ser Pro Ile Gln Val Pro Met 
                85                  90                  95      


Val Ala Gly Ser Pro Leu Gly Ala Xaa Gln Xaa Cys Asn Lys Val Arg 
            100                 105                 110         


Cys Val Val Pro Gln Xaa Xaa Val Ile Leu Asn Asn Asp Arg Gln Asn 
        115                 120                 125             


Ala Ile Val Ala Lys Met Glu Asp Pro Leu Ser Asn Arg Ala Pro Asp 
    130                 135                 140                 


Ser Leu Glu Asn Val Ile Ser Asn Ala Val Pro Gly Arg Arg Gln Asn 
145                 150                 155                 160 


Xaa Ile Val Val Lys Val Pro Gly Gln Glu Asp Ser His His Glu Asp 
                165                 170                 175     


Gly Glu Ser Gly Ser Glu Ala Ser Asp Ser Val Ser Ser Cys Gly Gln 
            180                 185                 190         


Ala Gly Ser Gln Ser Ile Gly Ser Asn Val Xaa Leu Ile Xaa Leu Asn 
        195                 200                 205             


Ser Glu Glu Asp Tyr Pro Asn Gly Xaa Trp Leu Gly Asp Glu Asn Asn 
    210                 215                 220                 


Pro Glu Met Arg Val Arg Cys Ala Ile Ile Pro Ser Asp Met Leu His 
225                 230                 235                 240 


Ile Ser Xaa Asn Cys Arg Xaa Ala Glu Lys Met Ala Leu Xaa Leu Leu 
                245                 250                 255     


Asp Tyr Leu Phe His Arg Glu Val Gln Ala Val Ser Asn Leu Ser Gly 
            260                 265                 270         


Gln Gly Lys His Gly Lys Lys Gln Leu Asp Pro Leu Xaa Ile Tyr Gly 
        275                 280                 285             


Ile Arg Cys His Leu Phe Tyr Lys Phe Gly Ile Xaa Glu Ser Asp Trp 
    290                 295                 300                 


Tyr Arg Ile Lys Gln Ser Ile Asp Ser Lys Cys Arg Xaa Ala Trp Arg 
305                 310                 315                 320 


Arg Lys Gln Arg Gly Gln Ser Leu Ala Val Lys Ser Phe Ser Arg Arg 
                325                 330                 335     


Xaa Pro Asn Ser Ser Ser Tyr Cys Pro Ser Glu Pro Met Met Ser Xaa 
            340                 345                 350         


Pro Pro Pro Ala Ser Glu Leu Pro Gln Pro Gln Pro Gln Pro Gln Ala 
        355                 360                 365             


Leu His Tyr Ala Leu Ala Asn Ala Gln Gln Val Gln Ile His Gln Ile 
    370                 375                 380                 


Gly Glu Asp Gly Gln Val Gln Val Gly His Leu His Ile Ala Gln Val 
385                 390                 395                 400 


Pro Gln Gly Glu Gln Val Gln Ile Xaa Gln Asp Ser Glu Gly Asn Leu 
                405                 410                 415     


Gln Ile His His Val Gly Gln Asp Gly Gln Leu Leu Glu Ala Xaa Arg 
            420                 425                 430         


Ile Pro Cys Leu Leu Ala Pro Ser Val Phe Lys Ala Ser Ser Gly Gln 
        435                 440                 445             


Val Leu Gln Gly Ala Gln Leu Ile Ala Val Ala Ser Ser Asp Pro Ala 
    450                 455                 460                 


Ala Ala Gly Val Asp Gly Ser Pro Leu Gln Gly Ser Asp Ile Gln Val 
465                 470                 475                 480 


Gln Tyr Val Gln Leu Ala Pro Val Ser Asp His Xaa Ala Gly Ala Gln 
                485                 490                 495     


Xaa Ala Glu Ala Leu Gln Pro Xaa Leu Gln Pro Glu Met Gln Leu Glu 
            500                 505                 510         


His Gly Ala Ile Gln Ile Gln 
        515                 


<210> 3917
<211> 56
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<400> 3917
Met Arg Ser Leu Pro Val Arg Ser His Glu Ala Glu Gly Ile Ala Val 
1               5                   10                  15      


Cys Cys Xaa Gln Gly Xaa Pro Ala Pro Gln Pro Leu Ser Ser Trp Asp 
            20                  25                  30          


Tyr Pro Val Val Leu Glu Asn His Val Val Xaa Asp Glu Asp Glu Pro 
        35                  40                  45              


Ala Leu Lys Arg Gln Arg Leu Glu 
    50                  55      


<210> 3918
<211> 758
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<400> 3918
Met Pro Asp Asn Arg Gln Pro Arg Asn Arg Gln Pro Arg Ile Arg Ser 
1               5                   10                  15      


Gly Asn Glu Pro Arg Ser Ala Pro Ala Met Glu Pro Asp Gly Arg Gly 
            20                  25                  30          


Ala Trp Ala His Ser Arg Ala Ala Leu Asp Arg Leu Glu Lys Leu Leu 
        35                  40                  45              


Arg Cys Ser Arg Cys Asn Cys Val Ser Asp Cys Ile Gly Xaa Gly Cys 
    50                  55                  60                  


Pro Val Cys Tyr Xaa Pro Ala Trp Ile Gln Asp Leu Lys Ile Asn Arg 
65                  70                  75                  80  


Gln Leu Asp Ser Met Ile Gln Leu Cys Ser Lys Leu Arg Asn Leu Leu 
                85                  90                  95      


His Asp Asn Glu Leu Ser Asp Leu Lys Glu Asp Lys Pro Arg Lys Ser 
            100                 105                 110         


Leu Phe Asn Asp Ala Gly Asn Lys Lys Asn Ser Ile Lys Met Trp Phe 
        115                 120                 125             


Ser Pro Arg Ser Lys Lys Val Arg Tyr Val Val Ser Lys Ala Ser Val 
    130                 135                 140                 


Gln Xaa Gln Pro Ala Ile Lys Lys Asp Ala Ser Ala Gln Gln Asp Ser 
145                 150                 155                 160 


Tyr Glu Phe Val Ser Pro Ser Pro Pro Ala Asp Val Ser Glu Arg Ala 
                165                 170                 175     


Lys Lys Ala Ser Ala Arg Ser Gly Lys Lys Gln Lys Lys Lys Xaa Leu 
            180                 185                 190         


Ala Glu Ile Asn Gln Lys Trp Asn Leu Glu Ala Glu Lys Glu Asp Gly 
        195                 200                 205             


Glu Phe Asp Ser Lys Glu Glu Ser Lys Gln Lys Leu Val Ser Phe Cys 
    210                 215                 220                 


Ser Gln Pro Ser Val Ile Ser Ser Pro Gln Ile Asn Gly Glu Ile Asp 
225                 230                 235                 240 


Leu Leu Ala Ser Gly Ser Leu Xaa Glu Ser Glu Cys Phe Gly Ser Leu 
                245                 250                 255     


Xaa Glu Val Ser Leu Pro Leu Ala Glu Gln Ile Glu Ser Pro Asp Xaa 
            260                 265                 270         


Lys Ser Arg Asn Glu Val Val Xaa Pro Glu Lys Val Cys Lys Asn Tyr 
        275                 280                 285             


Leu Xaa Ser Lys Lys Ser Leu Pro Leu Glu Asn Asn Gly Lys Arg Gly 
    290                 295                 300                 


His His Asn Arg Leu Ser Ser Pro Ile Ser Lys Arg Cys Arg Xaa Ser 
305                 310                 315                 320 


Ile Leu Ser Xaa Ser Gly Asp Phe Val Lys Gln Xaa Val Pro Ser Glu 
                325                 330                 335     


Asn Ile Pro Leu Pro Glu Cys Ser Ser Pro Pro Ser Cys Lys Arg Lys 
            340                 345                 350         


Val Gly Gly Xaa Ser Gly Arg Lys Asn Ser Asn Met Ser Asp Glu Phe 
        355                 360                 365             


Ile Ser Leu Ser Pro Gly Xaa Pro Pro Ser Xaa Leu Ser Ser Ser Ser 
    370                 375                 380                 


Tyr Arg Arg Val Met Ser Ser Pro Ser Ala Met Lys Leu Leu Pro Asn 
385                 390                 395                 400 


Met Ala Val Lys Arg Asn His Arg Gly Glu Xaa Leu Leu His Ile Ala 
                405                 410                 415     


Ser Ile Lys Gly Asp Ile Pro Ser Val Glu Tyr Leu Leu Gln Asn Gly 
            420                 425                 430         


Ser Asp Pro Asn Val Lys Asp His Ala Gly Trp Xaa Pro Leu His Glu 
        435                 440                 445             


Ala Cys Asn His Gly His Leu Lys Val Val Glu Leu Leu Leu Gln His 
    450                 455                 460                 


Lys Ala Leu Val Asn Xaa Xaa Gly Tyr Gln Asn Asp Ser Pro Leu His 
465                 470                 475                 480 


Asp Ala Ala Lys Asn Gly His Val Asp Ile Val Lys Leu Leu Leu Ser 
                485                 490                 495     


Tyr Gly Ala Ser Arg Asn Ala Val Asn Ile Phe Gly Leu Arg Pro Val 
            500                 505                 510         


Asp Tyr Xaa Asp Asp Glu Ser Met Lys Ser Leu Leu Leu Leu Pro Glu 
        515                 520                 525             


Lys Asn Glu Ser Ser Ser Ala Ser His Cys Ser Val Met Asn Xaa Gly 
    530                 535                 540                 


Gln Arg Arg Asp Gly Pro Leu Val Leu Ile Gly Ser Gly Leu Ser Ser 
545                 550                 555                 560 


Glu Gln Gln Lys Met Leu Ser Glu Leu Ala Val Ile Leu Lys Ala Lys 
                565                 570                 575     


Lys Tyr Xaa Glu Phe Asp Ser Xaa Val Xaa His Val Val Val Pro Gly 
            580                 585                 590         


Asp Ala Val Gln Ser Xaa Leu Lys Cys Met Leu Gly Ile Leu Asn Gly 
        595                 600                 605             


Cys Trp Ile Leu Lys Phe Glu Trp Val Lys Ala Cys Leu Arg Arg Lys 
    610                 615                 620                 


Val Cys Glu Gln Glu Glu Lys Tyr Glu Ile Pro Glu Gly Pro Arg Arg 
625                 630                 635                 640 


Ser Arg Leu Asn Arg Glu Gln Leu Leu Pro Lys Leu Phe Asp Gly Cys 
                645                 650                 655     


Tyr Phe Tyr Leu Trp Gly Xaa Phe Lys His His Pro Lys Asp Asn Leu 
            660                 665                 670         


Ile Lys Leu Val Xaa Ala Gly Gly Gly Gln Ile Leu Ser Arg Lys Pro 
        675                 680                 685             


Lys Pro Asp Ser Asp Val Xaa Gln Xaa Ile Asn Xaa Val Ala Tyr His 
    690                 695                 700                 


Ala Arg Pro Asp Ser Asp Gln Arg Phe Cys Xaa Gln Tyr Ile Ile Tyr 
705                 710                 715                 720 


Glu Asp Leu Cys Asn Tyr His Pro Glu Arg Val Arg Gln Gly Lys Val 
                725                 730                 735     


Trp Lys Ala Pro Ser Ser Trp Phe Ile Asp Cys Val Met Ser Phe Glu 
            740                 745                 750         


Leu Leu Pro Leu Asp Ser 
        755             


<210> 3919
<211> 307
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<400> 3919
Met Pro Asp Asn Arg Gln Pro Arg Asn Arg Gln Pro Arg Ile Arg Ser 
1               5                   10                  15      


Gly Asn Glu Pro Arg Ser Ala Pro Ala Met Glu Pro Asp Gly Arg Gly 
            20                  25                  30          


Ala Trp Ala His Ser Arg Ala Ala Leu Asp Arg Leu Glu Lys Leu Leu 
        35                  40                  45              


Arg Cys Ser Arg Cys Asn Ile Phe Gly Leu Arg Pro Val Asp Tyr Xaa 
    50                  55                  60                  


Asp Asp Glu Ser Met Lys Ser Leu Leu Leu Leu Pro Glu Lys Asn Glu 
65                  70                  75                  80  


Ser Ser Ser Ala Ser His Cys Ser Val Met Asn Xaa Gly Gln Arg Arg 
                85                  90                  95      


Asp Gly Pro Leu Val Leu Ile Gly Ser Gly Leu Ser Ser Glu Gln Gln 
            100                 105                 110         


Lys Met Leu Ser Glu Leu Ala Val Ile Leu Lys Ala Lys Lys Tyr Xaa 
        115                 120                 125             


Glu Phe Asp Ser Xaa Val Xaa His Val Val Val Pro Gly Asp Ala Val 
    130                 135                 140                 


Gln Ser Xaa Leu Lys Cys Met Leu Gly Ile Leu Asn Gly Cys Trp Ile 
145                 150                 155                 160 


Leu Lys Phe Glu Trp Val Lys Ala Cys Leu Arg Arg Lys Val Cys Glu 
                165                 170                 175     


Gln Glu Glu Lys Tyr Glu Ile Pro Glu Gly Pro Arg Arg Ser Arg Leu 
            180                 185                 190         


Asn Arg Glu Gln Leu Leu Pro Lys Leu Phe Asp Gly Cys Tyr Phe Tyr 
        195                 200                 205             


Leu Trp Gly Xaa Phe Lys His His Pro Lys Asp Asn Leu Ile Lys Leu 
    210                 215                 220                 


Val Xaa Ala Gly Gly Gly Gln Ile Leu Ser Arg Lys Pro Lys Pro Asp 
225                 230                 235                 240 


Ser Asp Val Xaa Gln Xaa Ile Asn Xaa Val Ala Tyr His Ala Arg Pro 
                245                 250                 255     


Asp Ser Asp Gln Arg Phe Cys Xaa Gln Tyr Ile Ile Tyr Glu Asp Leu 
            260                 265                 270         


Cys Asn Tyr His Pro Glu Arg Val Arg Gln Gly Lys Val Trp Lys Ala 
        275                 280                 285             


Pro Ser Ser Trp Phe Ile Asp Cys Val Met Ser Phe Glu Leu Leu Pro 
    290                 295                 300                 


Leu Asp Ser 
305         


<210> 3920
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<400> 3920
Met Pro Asp Asn Arg Gln Pro Arg Asn Arg Gln Pro Arg Ile Arg Ser 
1               5                   10                  15      


Gly Asn Glu Pro Arg Ser Ala Pro Ala Met Glu Pro Asp Gly Arg Gly 
            20                  25                  30          


Ala Trp Ala His Ser Arg Ala Ala Leu Asp Arg Leu Glu Lys Leu Leu 
        35                  40                  45              


Arg Cys Ser Arg Cys Xaa Asn Ile Leu Arg Glu Pro Val Cys Leu Gly 
    50                  55                  60                  


Gly Cys Glu His Ile Phe Cys Arg Phe Glu Arg Arg 
65                  70                  75      


<210> 3921
<211> 777
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<400> 3921
Met Pro Asp Asn Arg Gln Pro Arg Asn Arg Gln Pro Arg Ile Arg Ser 
1               5                   10                  15      


Gly Asn Glu Pro Arg Ser Ala Pro Ala Met Glu Pro Asp Gly Arg Gly 
            20                  25                  30          


Ala Trp Ala His Ser Arg Ala Ala Leu Asp Arg Leu Glu Lys Leu Leu 
        35                  40                  45              


Arg Cys Ser Arg Cys Xaa Asn Ile Leu Arg Glu Pro Val Cys Leu Gly 
    50                  55                  60                  


Gly Cys Glu His Ile Phe Cys Ser Asn Cys Val Ser Asp Cys Ile Gly 
65                  70                  75                  80  


Xaa Gly Cys Pro Val Cys Tyr Xaa Pro Ala Trp Ile Gln Asp Leu Lys 
                85                  90                  95      


Ile Asn Arg Gln Leu Asp Ser Met Ile Gln Leu Cys Ser Lys Leu Arg 
            100                 105                 110         


Asn Leu Leu His Asp Asn Glu Leu Ser Asp Leu Lys Glu Asp Lys Pro 
        115                 120                 125             


Arg Lys Ser Leu Phe Asn Asp Ala Gly Asn Lys Lys Asn Ser Ile Lys 
    130                 135                 140                 


Met Trp Phe Ser Pro Arg Ser Lys Lys Val Arg Tyr Val Val Ser Lys 
145                 150                 155                 160 


Ala Ser Val Gln Xaa Gln Pro Ala Ile Lys Lys Asp Ala Ser Ala Gln 
                165                 170                 175     


Gln Asp Ser Tyr Glu Phe Val Ser Pro Ser Pro Pro Ala Asp Val Ser 
            180                 185                 190         


Glu Arg Ala Lys Lys Ala Ser Ala Arg Ser Gly Lys Lys Gln Lys Lys 
        195                 200                 205             


Lys Xaa Leu Ala Glu Ile Asn Gln Lys Trp Asn Leu Glu Ala Glu Lys 
    210                 215                 220                 


Glu Asp Gly Glu Phe Asp Ser Lys Glu Glu Ser Lys Gln Lys Leu Val 
225                 230                 235                 240 


Ser Phe Cys Ser Gln Pro Ser Val Ile Ser Ser Pro Gln Ile Asn Gly 
                245                 250                 255     


Glu Ile Asp Leu Leu Ala Ser Gly Ser Leu Xaa Glu Ser Glu Cys Phe 
            260                 265                 270         


Gly Ser Leu Xaa Glu Val Ser Leu Pro Leu Ala Glu Gln Ile Glu Ser 
        275                 280                 285             


Pro Asp Xaa Lys Ser Arg Asn Glu Val Val Xaa Pro Glu Lys Val Cys 
    290                 295                 300                 


Lys Asn Tyr Leu Xaa Ser Lys Lys Ser Leu Pro Leu Glu Asn Asn Gly 
305                 310                 315                 320 


Lys Arg Gly His His Asn Arg Leu Ser Ser Pro Ile Ser Lys Arg Cys 
                325                 330                 335     


Arg Xaa Ser Ile Leu Ser Xaa Ser Gly Asp Phe Val Lys Gln Xaa Val 
            340                 345                 350         


Pro Ser Glu Asn Ile Pro Leu Pro Glu Cys Ser Ser Pro Pro Ser Cys 
        355                 360                 365             


Lys Arg Lys Val Gly Gly Xaa Ser Gly Arg Lys Asn Ser Asn Met Ser 
    370                 375                 380                 


Asp Glu Phe Ile Ser Leu Ser Pro Gly Xaa Pro Pro Ser Xaa Leu Ser 
385                 390                 395                 400 


Ser Ser Ser Tyr Arg Arg Val Met Ser Ser Pro Ser Ala Met Lys Leu 
                405                 410                 415     


Leu Pro Asn Met Ala Val Lys Arg Asn His Arg Gly Glu Xaa Leu Leu 
            420                 425                 430         


His Ile Ala Ser Ile Lys Gly Asp Ile Pro Ser Val Glu Tyr Leu Leu 
        435                 440                 445             


Gln Asn Gly Ser Asp Pro Asn Val Lys Asp His Ala Gly Trp Xaa Pro 
    450                 455                 460                 


Leu His Glu Ala Cys Asn His Gly His Leu Lys Val Val Glu Leu Leu 
465                 470                 475                 480 


Leu Gln His Lys Ala Leu Val Asn Xaa Xaa Gly Tyr Gln Asn Asp Ser 
                485                 490                 495     


Pro Leu His Asp Ala Ala Lys Asn Gly His Val Asp Ile Val Lys Leu 
            500                 505                 510         


Leu Leu Ser Tyr Gly Ala Ser Arg Asn Ala Val Asn Ile Phe Gly Leu 
        515                 520                 525             


Arg Pro Val Asp Tyr Xaa Asp Asp Glu Ser Met Lys Ser Leu Leu Leu 
    530                 535                 540                 


Leu Pro Glu Lys Asn Glu Ser Ser Ser Ala Ser His Cys Ser Val Met 
545                 550                 555                 560 


Asn Xaa Gly Gln Arg Arg Asp Gly Pro Leu Val Leu Ile Gly Ser Gly 
                565                 570                 575     


Leu Ser Ser Glu Gln Gln Lys Met Leu Ser Glu Leu Ala Val Ile Leu 
            580                 585                 590         


Lys Ala Lys Lys Tyr Xaa Glu Phe Asp Ser Xaa Val Xaa His Val Val 
        595                 600                 605             


Val Pro Gly Asp Ala Val Gln Ser Xaa Leu Lys Cys Met Leu Gly Ile 
    610                 615                 620                 


Leu Asn Gly Cys Trp Ile Leu Lys Phe Glu Trp Val Lys Ala Cys Leu 
625                 630                 635                 640 


Arg Arg Lys Val Cys Glu Gln Glu Glu Lys Tyr Glu Ile Pro Glu Gly 
                645                 650                 655     


Pro Arg Arg Ser Arg Leu Asn Arg Glu Gln Leu Leu Pro Lys Leu Phe 
            660                 665                 670         


Asp Gly Cys Tyr Phe Tyr Leu Trp Gly Xaa Phe Lys His His Pro Lys 
        675                 680                 685             


Asp Asn Leu Ile Lys Leu Val Xaa Ala Gly Gly Gly Gln Ile Leu Ser 
    690                 695                 700                 


Arg Lys Pro Lys Pro Asp Ser Asp Val Xaa Gln Xaa Ile Asn Xaa Val 
705                 710                 715                 720 


Ala Tyr His Ala Arg Pro Asp Ser Asp Gln Arg Phe Cys Xaa Gln Tyr 
                725                 730                 735     


Ile Ile Tyr Glu Asp Leu Cys Asn Tyr His Pro Glu Arg Val Arg Gln 
            740                 745                 750         


Gly Lys Val Trp Lys Ala Pro Ser Ser Trp Phe Ile Asp Cys Val Met 
        755                 760                 765             


Ser Phe Glu Leu Leu Pro Leu Asp Ser 
    770                 775         


<210> 3922
<211> 127
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<400> 3922
Met Pro Asp Asn Arg Gln Pro Arg Asn Arg Gln Pro Arg Ile Arg Ser 
1               5                   10                  15      


Gly Asn Glu Pro Arg Ser Ala Pro Ala Met Glu Pro Asp Gly Arg Gly 
            20                  25                  30          


Ala Trp Ala His Ser Arg Ala Ala Leu Asp Arg Leu Glu Lys Leu Leu 
        35                  40                  45              


Arg Cys Ser Arg Cys Xaa Asn Ile Leu Arg Glu Pro Val Cys Leu Gly 
    50                  55                  60                  


Gly Cys Glu His Ile Phe Cys Ser Asn Cys Val Ser Asp Cys Ile Gly 
65                  70                  75                  80  


Xaa Gly Cys Pro Val Cys Tyr Xaa Pro Ala Trp Ile Gln Asp Leu Lys 
                85                  90                  95      


Ile Asn Arg Gln Leu Asp Ser Met Ile Gln Leu Cys Ser Lys Leu Arg 
            100                 105                 110         


Asn Leu Leu His Asp Asn Glu Leu Ser Gly Arg His Xaa Phe Cys 
        115                 120                 125         


<210> 3923
<211> 264
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<400> 3923
Met Pro Asp Asn Arg Gln Pro Arg Asn Arg Gln Pro Arg Ile Arg Ser 
1               5                   10                  15      


Gly Asn Glu Pro Arg Ser Ala Pro Ala Met Glu Pro Asp Gly Arg Gly 
            20                  25                  30          


Ala Trp Ala His Ser Arg Ala Ala Leu Asp Arg Leu Glu Lys Leu Leu 
        35                  40                  45              


Arg Cys Ser Arg Cys Xaa Asn Ile Leu Arg Glu Pro Val Cys Leu Gly 
    50                  55                  60                  


Gly Cys Glu His Ile Phe Cys Ser Asn Cys Val Ser Asp Cys Ile Gly 
65                  70                  75                  80  


Xaa Gly Cys Pro Val Cys Tyr Xaa Pro Ala Trp Ile Gln Asp Leu Lys 
                85                  90                  95      


Ile Asn Arg Gln Leu Asp Ser Met Ile Gln Leu Cys Ser Lys Leu Arg 
            100                 105                 110         


Asn Leu Leu His Asp Asn Glu Leu Ser Gly Val Lys Ala Cys Leu Arg 
        115                 120                 125             


Arg Lys Val Cys Glu Gln Glu Glu Lys Tyr Glu Ile Pro Glu Gly Pro 
    130                 135                 140                 


Arg Arg Ser Arg Leu Asn Arg Glu Gln Leu Leu Pro Lys Leu Phe Asp 
145                 150                 155                 160 


Gly Cys Tyr Phe Tyr Leu Trp Gly Xaa Phe Lys His His Pro Lys Asp 
                165                 170                 175     


Asn Leu Ile Lys Leu Val Xaa Ala Gly Gly Gly Gln Ile Leu Ser Arg 
            180                 185                 190         


Lys Pro Lys Pro Asp Ser Asp Val Xaa Gln Xaa Ile Asn Xaa Val Ala 
        195                 200                 205             


Tyr His Ala Arg Pro Asp Ser Asp Gln Arg Phe Cys Xaa Gln Tyr Ile 
    210                 215                 220                 


Ile Tyr Glu Asp Leu Cys Asn Tyr His Pro Glu Arg Val Arg Gln Gly 
225                 230                 235                 240 


Lys Val Trp Lys Ala Pro Ser Ser Trp Phe Ile Asp Cys Val Met Ser 
                245                 250                 255     


Phe Glu Leu Leu Pro Leu Asp Ser 
            260                 


<210> 3924
<211> 216
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 3924
Met Pro Asp Asn Arg Gln Pro Arg Asn Arg Gln Pro Arg Ile Arg Ser 
1               5                   10                  15      


Gly Asn Glu Pro Arg Ser Ala Pro Ala Met Glu Pro Asp Gly Arg Gly 
            20                  25                  30          


Ala Trp Ala His Ser Arg Ala Ala Leu Asp Arg Leu Glu Lys Leu Leu 
        35                  40                  45              


Arg Cys Ser Arg Cys Xaa Asn Ile Leu Arg Glu Pro Val Cys Leu Gly 
    50                  55                  60                  


Gly Cys Glu His Ile Phe Cys Ser Asn Ile Phe Gly Leu Arg Pro Val 
65                  70                  75                  80  


Asp Tyr Xaa Asp Asp Glu Ser Met Lys Ser Leu Leu Leu Leu Pro Glu 
                85                  90                  95      


Lys Asn Glu Ser Ser Ser Ala Ser His Cys Ser Val Met Asn Xaa Gly 
            100                 105                 110         


Gln Arg Arg Asp Gly Pro Leu Val Leu Ile Gly Ser Gly Leu Ser Ser 
        115                 120                 125             


Glu Gln Gln Lys Met Leu Ser Glu Leu Ala Val Ile Leu Lys Ala Lys 
    130                 135                 140                 


Lys Tyr Xaa Glu Phe Asp Ser Xaa Val Xaa His Val Val Val Pro Gly 
145                 150                 155                 160 


Asp Ala Val Gln Ser Xaa Leu Lys Cys Met Leu Gly Ile Leu Asn Gly 
                165                 170                 175     


Cys Trp Ile Leu Lys Phe Glu Trp Val Lys Ala Cys Leu Arg Arg Lys 
            180                 185                 190         


Val Cys Glu Gln Glu Glu Lys Tyr Glu Ile Pro Glu Gly Pro Arg Arg 
        195                 200                 205             


Ser Arg Leu Asn Arg Glu Gln Leu 
    210                 215     


<210> 3925
<211> 326
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<400> 3925
Met Pro Asp Asn Arg Gln Pro Arg Asn Arg Gln Pro Arg Ile Arg Ser 
1               5                   10                  15      


Gly Asn Glu Pro Arg Ser Ala Pro Ala Met Glu Pro Asp Gly Arg Gly 
            20                  25                  30          


Ala Trp Ala His Ser Arg Ala Ala Leu Asp Arg Leu Glu Lys Leu Leu 
        35                  40                  45              


Arg Cys Ser Arg Cys Xaa Asn Ile Leu Arg Glu Pro Val Cys Leu Gly 
    50                  55                  60                  


Gly Cys Glu His Ile Phe Cys Ser Asn Ile Phe Gly Leu Arg Pro Val 
65                  70                  75                  80  


Asp Tyr Xaa Asp Asp Glu Ser Met Lys Ser Leu Leu Leu Leu Pro Glu 
                85                  90                  95      


Lys Asn Glu Ser Ser Ser Ala Ser His Cys Ser Val Met Asn Xaa Gly 
            100                 105                 110         


Gln Arg Arg Asp Gly Pro Leu Val Leu Ile Gly Ser Gly Leu Ser Ser 
        115                 120                 125             


Glu Gln Gln Lys Met Leu Ser Glu Leu Ala Val Ile Leu Lys Ala Lys 
    130                 135                 140                 


Lys Tyr Xaa Glu Phe Asp Ser Xaa Val Xaa His Val Val Val Pro Gly 
145                 150                 155                 160 


Asp Ala Val Gln Ser Xaa Leu Lys Cys Met Leu Gly Ile Leu Asn Gly 
                165                 170                 175     


Cys Trp Ile Leu Lys Phe Glu Trp Val Lys Ala Cys Leu Arg Arg Lys 
            180                 185                 190         


Val Cys Glu Gln Glu Glu Lys Tyr Glu Ile Pro Glu Gly Pro Arg Arg 
        195                 200                 205             


Ser Arg Leu Asn Arg Glu Gln Leu Leu Pro Lys Leu Phe Asp Gly Cys 
    210                 215                 220                 


Tyr Phe Tyr Leu Trp Gly Xaa Phe Lys His His Pro Lys Asp Asn Leu 
225                 230                 235                 240 


Ile Lys Leu Val Xaa Ala Gly Gly Gly Gln Ile Leu Ser Arg Lys Pro 
                245                 250                 255     


Lys Pro Asp Ser Asp Val Xaa Gln Xaa Ile Asn Xaa Val Ala Tyr His 
            260                 265                 270         


Ala Arg Pro Asp Ser Asp Gln Arg Phe Cys Xaa Gln Tyr Ile Ile Tyr 
        275                 280                 285             


Glu Asp Leu Cys Asn Tyr His Pro Glu Arg Val Arg Gln Gly Lys Val 
    290                 295                 300                 


Trp Lys Ala Pro Ser Ser Trp Phe Ile Asp Cys Val Met Ser Phe Glu 
305                 310                 315                 320 


Leu Leu Pro Leu Asp Ser 
                325     


<210> 3926
<211> 167
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<400> 3926
Met Val Ala Val Pro Gly Pro Xaa Val Ala Pro Arg Ser Xaa Ala Trp 
1               5                   10                  15      


Arg Ser Cys Cys Ala Ala Arg Val Gly Val Lys Ala Cys Leu Arg Arg 
            20                  25                  30          


Lys Val Cys Glu Gln Glu Glu Lys Tyr Glu Ile Pro Glu Gly Pro Arg 
        35                  40                  45              


Arg Ser Arg Leu Asn Arg Glu Gln Leu Leu Pro Lys Leu Phe Asp Gly 
    50                  55                  60                  


Cys Tyr Phe Tyr Leu Trp Gly Xaa Phe Lys His His Pro Lys Asp Asn 
65                  70                  75                  80  


Leu Ile Lys Leu Val Xaa Ala Gly Gly Gly Gln Ile Leu Ser Arg Lys 
                85                  90                  95      


Pro Lys Pro Asp Ser Asp Val Xaa Gln Xaa Ile Asn Xaa Val Ala Tyr 
            100                 105                 110         


His Ala Arg Pro Asp Ser Asp Gln Arg Phe Cys Xaa Gln Tyr Ile Ile 
        115                 120                 125             


Tyr Glu Asp Leu Cys Asn Tyr His Pro Glu Arg Val Arg Gln Gly Lys 
    130                 135                 140                 


Val Trp Lys Ala Pro Ser Ser Trp Phe Ile Asp Cys Val Met Ser Phe 
145                 150                 155                 160 


Glu Leu Leu Pro Leu Asp Ser 
                165         


<210> 3927
<211> 44
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 3927
Xaa Val Lys Ala Cys Leu Arg Arg Lys Val Cys Glu Gln Glu Glu Lys 
1               5                   10                  15      


Tyr Glu Ile Pro Glu Gly Pro Arg Arg Ser Arg Leu Asn Arg Glu Gln 
            20                  25                  30          


Leu His Leu Ile Leu Lys Asp Asp His Asp Glu Gln 
        35                  40                  


<210> 3928
<211> 327
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<400> 3928
Met Glu Gly Ser Asn Gly Phe Gly Ile Asp Ser Ile Leu Ser His Arg 
1               5                   10                  15      


Ala Gly Ser Pro Ala Leu Pro Lys Gly Asp Pro Leu Leu Gly Asp Cys 
            20                  25                  30          


Arg Ser Pro Leu Glu Leu Ser Pro Arg Ser Glu Ser Ser Ser Asp Cys 
        35                  40                  45              


Ser Ser Pro Ala Ser Pro Gly Arg Asp Cys Leu Glu Xaa Gly Xaa Pro 
    50                  55                  60                  


Arg Pro Gly Gly Ala Ser Gly Pro Gly Leu Asp Ser His Leu Gln Pro 
65                  70                  75                  80  


Gly Gln Leu Ser Ala Pro Ala Gln Ser Arg Xaa Val Xaa Ser Ser Phe 
                85                  90                  95      


Leu Ile Arg Asp Ile Leu Ala Asp Cys Lys Pro Leu Ala Ala Cys Ala 
            100                 105                 110         


Pro Tyr Ser Ser Ser Gly Gln Pro Ala Ala Pro Glu Pro Gly Gly Arg 
        115                 120                 125             


Leu Ala Ala Lys Ala Ala Glu Asp Phe Arg Asp Lys Leu Asp Lys Ser 
    130                 135                 140                 


Gly Ser Asn Ala Ser Ser Asp Ser Glu Tyr Lys Val Lys Glu Glu Gly 
145                 150                 155                 160 


Asp Arg Glu Ile Ser Ser Ser Arg Asp Ser Pro Pro Val Arg Leu Lys 
                165                 170                 175     


Lys Pro Arg Lys Ala Arg Xaa Ala Phe Xaa Asp His Gln Leu Ala Gln 
            180                 185                 190         


Leu Glu Arg Ser Phe Glu Arg Gln Lys Tyr Leu Ser Val Gln Asp Arg 
        195                 200                 205             


Met Glu Leu Ala Ala Ser Leu Asn Leu Xaa Asp Xaa Gln Val Lys Xaa 
    210                 215                 220                 


Trp Tyr Gln Asn Arg Arg Xaa Lys Trp Lys Arg Gln Xaa Ala Val Gly 
225                 230                 235                 240 


Leu Glu Leu Leu Ala Glu Ala Gly Asn Tyr Ser Ala Leu Gln Arg Met 
                245                 250                 255     


Phe Pro Ser Pro Tyr Phe Tyr Pro Gln Ser Leu Val Ser Asn Leu Asp 
            260                 265                 270         


Pro Gly Ala Ala Leu Tyr Leu Tyr Arg Gly Pro Ser Ala Pro Pro Pro 
        275                 280                 285             


Ala Leu Gln Arg Pro Leu Val Pro Arg Ile Leu Ile His Gly Leu Gln 
    290                 295                 300                 


Gly Ala Ser Glu Pro Pro Pro Pro Leu Pro Pro Leu Ala Gly Val Leu 
305                 310                 315                 320 


Pro Arg Ala Ala Gln Pro Arg 
                325         


<210> 3929
<211> 387
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<400> 3929
Met Xaa Met Glu Gly Ala Ser Gly Ser Ser Phe Gly Ile Asp Xaa Ile 
1               5                   10                  15      


Leu Ser Ser Ala Ser Ser Gly Ser Pro Gly Met Met Asn Gly Asp Phe 
            20                  25                  30          


Arg Pro Leu Gly Glu Ala Arg Xaa Ala Asp Phe Arg Ser Gln Ala Xaa 
        35                  40                  45              


Pro Ser Pro Cys Ser Glu Ile Asp Xaa Val Gly Xaa Ala Pro Ser Ser 
    50                  55                  60                  


Pro Ile Ser Val Xaa Met Glu Pro Pro Glu Pro His Leu Val Ala Asp 
65                  70                  75                  80  


Ala Xaa Gln His His His His Leu His His Ser Gln Gln Pro Pro Pro 
                85                  90                  95      


Pro Ala Ala Ala Pro Xaa Gln Ser Leu Gln Pro Leu Pro Gln Gln Gln 
            100                 105                 110         


Gln Pro Leu Pro Pro Gln Gln Pro Pro Pro Pro Pro Pro Gln Gln Leu 
        115                 120                 125             


Gly Ser Ala Ala Ser Ala Pro Arg Xaa Ser Xaa Ser Ser Phe Leu Ile 
    130                 135                 140                 


Lys Asp Ile Leu Gly Asp Ser Lys Pro Leu Ala Ala Cys Ala Pro Tyr 
145                 150                 155                 160 


Ser Xaa Ser Val Ser Ser Pro His His Xaa Pro Lys Gln Glu Ser Asn 
                165                 170                 175     


Ala Val His Glu Ser Phe Arg Pro Lys Leu Glu Gln Glu Asp Ser Lys 
            180                 185                 190         


Xaa Lys Leu Asp Lys Arg Glu Asp Ser Gln Ser Asp Ile Lys Cys His 
        195                 200                 205             


Gly Xaa Lys Glu Glu Gly Asp Arg Glu Ile Xaa Ser Ser Arg Glu Ser 
    210                 215                 220                 


Pro Pro Val Arg Ala Lys Lys Pro Arg Lys Ala Arg Xaa Ala Phe Ser 
225                 230                 235                 240 


Asp His Gln Leu Asn Gln Leu Glu Arg Ser Phe Glu Arg Gln Lys Tyr 
                245                 250                 255     


Leu Ser Val Gln Asp Arg Met Asp Leu Ala Ala Ala Leu Asn Leu Xaa 
            260                 265                 270         


Asp Xaa Gln Val Lys Xaa Trp Tyr Gln Asn Arg Arg Xaa Lys Trp Lys 
        275                 280                 285             


Arg Gln Xaa Ala Val Gly Leu Glu Leu Leu Ala Glu Ala Gly Asn Tyr 
    290                 295                 300                 


Ser Ala Leu Gln Arg Met Phe Pro Ser Pro Tyr Phe Tyr His Pro Ser 
305                 310                 315                 320 


Leu Leu Gly Ser Met Asp Ser Xaa Xaa Ala Ala Ala Ala Ala Ala Ala 
                325                 330                 335     


Met Tyr Ser Ser Met Tyr Arg Xaa Pro Pro Ala Pro His Pro Gln Leu 
            340                 345                 350         


Gln Arg Pro Leu Val Pro Arg Val Leu Ile His Gly Leu Gly Pro Gly 
        355                 360                 365             


Gly Gln Pro Ala Leu Asn Pro Leu Ser Ser Pro Ile Pro Gly Xaa Pro 
    370                 375                 380                 


His Pro Arg 
385         


<210> 3930
<211> 100
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<400> 3930
Met Gly Leu Glu Lys Arg Phe Glu Lys Gln Lys Tyr Leu Ser Xaa Pro 
1               5                   10                  15      


Asp Arg Ile Asp Leu Ala Glu Ser Leu Gly Leu Ser Gln Leu Gln Val 
            20                  25                  30          


Lys Xaa Trp Tyr Gln Asn Arg Arg Met Lys Trp Lys Lys Ile Val Leu 
        35                  40                  45              


Gln Gly Gly Gly Leu Glu Ser Pro Xaa Lys Pro Lys Gly Arg Pro Lys 
    50                  55                  60                  


Lys Asn Ser Ile Pro Xaa Ser Glu Gln Leu Xaa Glu Gln Glu Arg Ala 
65                  70                  75                  80  


Lys Asp Ala Glu Lys Pro Ala Glu Val Pro Gly Glu Pro Ser Asp Arg 
                85                  90                  95      


Ser Arg Glu Asp 
            100 


<210> 3931
<211> 254
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<400> 3931
Met Gln Arg Pro Gly Glu Pro Gly Ala Ala Arg Phe Gly Pro Pro Glu 
1               5                   10                  15      


Gly Cys Ala Asp His Arg Pro His Arg Tyr Arg Ser Phe Met Ile Glu 
            20                  25                  30          


Glu Ile Leu Xaa Glu Pro Pro Gly Pro Lys Gly Ala Ala Pro Ala Ala 
        35                  40                  45              


Ala Ala Ala Ala Ala Gly Glu Leu Leu Lys Phe Gly Val Gln Ala Leu 
    50                  55                  60                  


Leu Ala Ala Arg Pro Phe His Ser His Leu Ala Val Leu Lys Ala Glu 
65                  70                  75                  80  


Gln Ala Ala Val Phe Lys Phe Pro Leu Ala Pro Leu Gly Cys Ser Gly 
                85                  90                  95      


Leu Ser Ser Ala Leu Leu Ala Ala Gly Pro Gly Leu Pro Gly Ala Ala 
            100                 105                 110         


Gly Ala Pro His Leu Pro Leu Glu Leu Gln Leu Arg Gly Lys Leu Glu 
        115                 120                 125             


Ala Ala Gly Pro Gly Glu Pro Gly Xaa Lys Ala Lys Lys Gly Arg Arg 
    130                 135                 140                 


Ser Arg Xaa Val Phe Xaa Glu Leu Gln Leu Met Gly Leu Glu Lys Arg 
145                 150                 155                 160 


Phe Glu Lys Gln Lys Tyr Leu Ser Xaa Pro Asp Arg Ile Asp Leu Ala 
                165                 170                 175     


Glu Ser Leu Gly Leu Ser Gln Leu Gln Val Lys Xaa Trp Tyr Gln Asn 
            180                 185                 190         


Arg Arg Met Lys Trp Lys Lys Ile Val Leu Gln Gly Gly Gly Leu Glu 
        195                 200                 205             


Ser Pro Xaa Lys Pro Lys Gly Arg Pro Lys Lys Asn Ser Ile Pro Xaa 
    210                 215                 220                 


Ser Glu Gln Leu Xaa Glu Gln Glu Arg Ala Lys Asp Ala Glu Lys Pro 
225                 230                 235                 240 


Ala Glu Val Pro Gly Glu Pro Ser Asp Arg Ser Arg Glu Asp 
                245                 250                 


<210> 3932
<211> 279
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<400> 3932
Met His Cys His Ala Glu Leu Arg Leu Ser Ser Pro Gly Gln Leu Lys 
1               5                   10                  15      


Ala Ala Arg Arg Arg Tyr Lys Xaa Phe Met Ile Asp Glu Ile Leu Ser 
            20                  25                  30          


Lys Glu Xaa Cys Asp Tyr Phe Glu Lys Leu Ser Leu Tyr Ser Val Cys 
        35                  40                  45              


Pro Ser Leu Val Val Arg Pro Lys Pro Leu His Ser Cys Xaa Gly Ser 
    50                  55                  60                  


Pro Ser Leu Arg Ala Tyr Pro Leu Leu Ser Val Ile Xaa Arg Gln Pro 
65                  70                  75                  80  


Xaa Val Ile Ser His Leu Val Pro Ala Xaa Pro Gly Ile Ala Gln Ala 
                85                  90                  95      


Leu Ser Cys His Gln Val Xaa Glu Ala Val Ser Ala Glu Ala Pro Gly 
            100                 105                 110         


Gly Glu Ala Leu Ala Ser Ser Glu Ser Glu Xaa Glu Gln Pro Xaa Pro 
        115                 120                 125             


Arg Gln Lys Lys Pro Arg Arg Ser Arg Xaa Ile Phe Xaa Glu Leu Gln 
    130                 135                 140                 


Leu Met Gly Leu Glu Lys Lys Phe Gln Lys Gln Lys Tyr Leu Ser Xaa 
145                 150                 155                 160 


Pro Asp Arg Leu Asp Leu Ala Gln Ser Leu Gly Leu Xaa Gln Leu Gln 
                165                 170                 175     


Val Lys Xaa Trp Tyr Gln Asn Arg Arg Met Lys Trp Lys Lys Met Val 
            180                 185                 190         


Leu Lys Gly Gly Gln Glu Ala Pro Xaa Lys Pro Lys Gly Arg Pro Lys 
        195                 200                 205             


Lys Asn Ser Ile Pro Xaa Ser Glu Glu Ile Glu Ala Glu Glu Lys Met 
    210                 215                 220                 


Asn Ser Gln Ala Gln Gly Gln Glu Gln Leu Glu Pro Ser Gln Gly Gln 
225                 230                 235                 240 


Glu Glu Leu Cys Glu Ala Gln Glu Pro Lys Ala Arg Asp Val Pro Leu 
                245                 250                 255     


Glu Met Ala Glu Pro Pro Asp Pro Pro Gln Glu Leu Pro Ile Pro Ser 
            260                 265                 270         


Ser Glu Pro Pro Pro Leu Ser 
        275                 


<210> 3933
<211> 46
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<400> 3933
Met Gly Gly Lys Leu Ser Lys Lys Lys Lys Gly Tyr Asn Val Asn Asp 
1               5                   10                  15      


Glu Lys Ala Lys Glu Lys Asp Lys Lys Ala Glu Gly Ala Ala Xaa Glu 
            20                  25                  30          


Glu Glu Gly Xaa Pro Lys Glu Ser Glu Pro Gln Ala Ala Ala 
        35                  40                  45      


<210> 3934
<211> 227
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<400> 3934
Met Gly Gly Lys Leu Ser Lys Lys Lys Lys Gly Tyr Asn Val Asn Asp 
1               5                   10                  15      


Glu Lys Ala Lys Glu Lys Asp Lys Lys Ala Glu Gly Ala Ala Xaa Glu 
            20                  25                  30          


Glu Glu Gly Xaa Pro Lys Glu Ser Glu Pro Gln Ala Ala Ala Glu Pro 
        35                  40                  45              


Ala Glu Ala Lys Glu Gly Lys Glu Lys Pro Asp Gln Asp Ala Glu Gly 
    50                  55                  60                  


Lys Ala Glu Glu Lys Glu Gly Glu Lys Asp Ala Ala Ala Ala Lys Glu 
65                  70                  75                  80  


Glu Ala Pro Lys Ala Glu Pro Glu Lys Xaa Glu Gly Ala Ala Glu Ala 
                85                  90                  95      


Lys Ala Glu Pro Pro Lys Ala Pro Glu Gln Glu Gln Ala Ala Pro Gly 
            100                 105                 110         


Pro Ala Ala Gly Gly Glu Ala Pro Lys Ala Ala Glu Ala Ala Ala Ala 
        115                 120                 125             


Pro Ala Glu Ser Ala Ala Pro Ala Ala Gly Glu Glu Pro Ser Lys Glu 
    130                 135                 140                 


Glu Gly Glu Pro Lys Lys Xaa Glu Ala Pro Ala Ala Pro Ala Ala Gln 
145                 150                 155                 160 


Glu Xaa Lys Ser Asp Gly Ala Pro Ala Ser Asp Ser Lys Pro Gly Ser 
                165                 170                 175     


Ser Glu Ala Ala Pro Ser Ser Lys Glu Xaa Pro Ala Ala Xaa Glu Ala 
            180                 185                 190         


Pro Ser Ser Xaa Pro Lys Ala Gln Gly Pro Ala Ala Ser Ala Glu Glu 
        195                 200                 205             


Pro Lys Pro Val Glu Ala Pro Ala Ala Asn Ser Asp Gln Xaa Val Xaa 
    210                 215                 220                 


Val Lys Glu 
225         


<210> 3935
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<400> 3935
Met Pro His Ser Ser Asp Ser Ser Asp Ser Ser Phe Ser Arg Ser Pro 
1               5                   10                  15      


Pro Pro Gly Lys Gln Asp Ser Ser Asp Asp Val Arg Arg Val Gln Arg 
            20                  25                  30          


Arg Glu Lys Asn Arg Ile Ala Ala Gln Lys Ser Arg Gln Arg Gln Xaa 
        35                  40                  45              


Gln Lys Ala Asp Xaa Leu His Leu Glu Ser Glu Asp Leu Glu Lys Gln 
    50                  55                  60                  


Asn Ala Ala Leu Arg Lys Glu Ile Lys Gln Leu Xaa Glu Glu Leu Lys 
65                  70                  75                  80  


Tyr Phe Xaa Ser Val Leu Asn Ser His Glu Pro Leu Cys Ser Val Leu 
                85                  90                  95      


Ala Ala Ser Xaa Pro Ser Pro Pro Glu Val Val Tyr Ser Ala His Ala 
            100                 105                 110         


Phe His Gln Pro His Val Ser Ser Pro Arg Phe Gln Pro 
        115                 120                 125 


<210> 3936
<211> 73
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<400> 3936
Met Pro His Ser Ser Asp Ser Ser Asp Ser Ser Phe Ser Arg Ser Pro 
1               5                   10                  15      


Pro Pro Gly Lys Gln Asp Ser Ser Asp Asp Val Arg Arg Val Gln Arg 
            20                  25                  30          


Arg Glu Lys Asn Arg Ile Ala Ala Gln Lys Ser Arg Gln Arg Gln Xaa 
        35                  40                  45              


Gln Lys Ser Ile Lys Lys Asp Ala Gln Val Pro Trp His Arg Ala Arg 
    50                  55                  60                  


Arg Ala Gly Asn Gly Tyr Phe Ser Lys 
65                  70              


<210> 3937
<211> 250
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<400> 3937
Met Ala Pro Val Gly Lys Arg Ile Gly Gly Leu Gly Asp Xaa Arg Val 
1               5                   10                  15      


Gly Gly Pro Cys Ile Ser Gln Gln His Glu Ser Leu Glu Lys Asp Asn 
            20                  25                  30          


Leu Ala Leu Arg Lys Glu Ile Gln Ser Leu Gln Ala Glu Leu Ala Trp 
        35                  40                  45              


Trp Ser Arg Xaa Leu His Val His Glu Arg Leu Cys Pro Met Asp Cys 
    50                  55                  60                  


Ala Ser Cys Ser Ala Pro Gly Leu Leu Gly Cys Trp Asp Gln Ala Glu 
65                  70                  75                  80  


Gly Leu Leu Gly Pro Gly Pro Gln Gly Gln His Gly Cys Arg Glu Gln 
                85                  90                  95      


Leu Glu Leu Phe Gln Xaa Pro Gly Ser Cys Tyr Pro Ala Gln Pro Leu 
            100                 105                 110         


Ser Pro Gly Pro Gln Pro His Asp Ser Pro Ser Leu Leu Gln Cys Pro 
        115                 120                 125             


Leu Pro Ser Leu Ser Leu Gly Pro Ala Val Val Ala Glu Pro Pro Val 
    130                 135                 140                 


Gln Leu Ser Pro Ser Pro Leu Leu Phe Ala Ser His Xaa Gly Ser Ser 
145                 150                 155                 160 


Leu Gln Gly Ser Ser Ser Lys Leu Ser Ala Leu Gln Pro Ser Leu Xaa 
                165                 170                 175     


Ala Gln Xaa Ala Pro Pro Gln Pro Leu Glu Leu Glu His Pro Xaa Arg 
            180                 185                 190         


Gly Lys Leu Gly Ser Ser Pro Asp Asn Pro Ser Ser Ala Leu Gly Leu 
        195                 200                 205             


Ala Arg Leu Gln Ser Arg Glu His Lys Pro Ala Leu Ser Ala Ala Xaa 
    210                 215                 220                 


Trp Gln Gly Leu Val Val Asp Pro Ser Pro His Pro Leu Leu Ala Phe 
225                 230                 235                 240 


Pro Leu Leu Ser Ser Ala Gln Val His Phe 
                245                 250 


<210> 3938
<211> 189
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<400> 3938
Met Asp Cys Ala Ser Cys Ser Ala Pro Gly Leu Leu Gly Cys Trp Asp 
1               5                   10                  15      


Gln Ala Glu Gly Leu Leu Gly Pro Gly Pro Gln Gly Gln His Gly Cys 
            20                  25                  30          


Arg Glu Gln Leu Glu Leu Phe Gln Xaa Pro Gly Ser Cys Tyr Pro Ala 
        35                  40                  45              


Gln Pro Leu Ser Pro Gly Pro Gln Pro His Asp Ser Pro Ser Leu Leu 
    50                  55                  60                  


Gln Cys Pro Leu Pro Ser Leu Ser Leu Gly Pro Ala Val Val Ala Glu 
65                  70                  75                  80  


Pro Pro Val Gln Leu Ser Pro Ser Pro Leu Leu Phe Ala Ser His Xaa 
                85                  90                  95      


Gly Ser Ser Leu Gln Gly Ser Ser Ser Lys Leu Ser Ala Leu Gln Pro 
            100                 105                 110         


Ser Leu Xaa Ala Gln Xaa Ala Pro Pro Gln Pro Leu Glu Leu Glu His 
        115                 120                 125             


Pro Xaa Arg Gly Lys Leu Gly Ser Ser Pro Asp Asn Pro Ser Ser Ala 
    130                 135                 140                 


Leu Gly Leu Ala Arg Leu Gln Ser Arg Glu His Lys Pro Ala Leu Ser 
145                 150                 155                 160 


Ala Ala Xaa Trp Gln Gly Leu Val Val Asp Pro Ser Pro His Pro Leu 
                165                 170                 175     


Leu Ala Phe Pro Leu Leu Ser Ser Ala Gln Val His Phe 
            180                 185                 


<210> 3939
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<400> 3939
Met His Leu Cys Gly Gly Asn Gly Leu Leu Xaa Gln Xaa Asp Pro Lys 
1               5                   10                  15      


Glu Gln Gln Arg Gln Leu Lys Lys Gln Lys Asn Arg Ala Ala Ala Gln 
            20                  25                  30          


Arg Ser Arg Gln Lys His Xaa Asp Lys Ala Asp Ala Leu His Gln His 
        35                  40                  45              


Glu Ser Leu Glu Lys Asp Asn Leu Ala Leu Arg Lys Glu Ile Gln Ser 
    50                  55                  60                  


Leu Gln Ala Glu Leu Ala Trp Trp Ser Arg Xaa Leu His Val His Glu 
65                  70                  75                  80  


Arg Leu Cys Pro Met Asp Cys Ala Ser Cys Ser Ala Pro Gly Leu Leu 
                85                  90                  95      


Gly Cys Trp Asp Gln Ala Glu Gly Leu Leu Gly Pro Gly Pro Gln Gly 
            100                 105                 110         


Gln His Gly Cys Arg Glu Gln Leu Glu Leu Phe Gln Xaa Pro Gly Ser 
        115                 120                 125             


Cys Tyr Pro Ala Gln Pro Leu Ser Pro Gly Pro Gln Pro His Asp Ser 
    130                 135                 140                 


Pro Ser Leu Leu Gln Cys Pro Leu Pro Ser Leu 
145                 150                 155 


<210> 3940
<211> 274
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<400> 3940
Met His Leu Cys Gly Gly Asn Gly Leu Leu Xaa Gln Xaa Asp Pro Lys 
1               5                   10                  15      


Glu Gln Gln Arg Gln Leu Lys Lys Gln Lys Asn Arg Ala Ala Ala Gln 
            20                  25                  30          


Arg Ser Arg Gln Lys His Xaa Asp Lys Ala Asp Ala Leu His Gln Gln 
        35                  40                  45              


His Glu Ser Leu Glu Lys Asp Asn Leu Ala Leu Arg Lys Glu Ile Gln 
    50                  55                  60                  


Ser Leu Gln Ala Glu Leu Ala Trp Trp Ser Arg Xaa Leu His Val His 
65                  70                  75                  80  


Glu Arg Leu Cys Pro Met Asp Cys Ala Ser Cys Ser Ala Pro Gly Leu 
                85                  90                  95      


Leu Gly Cys Trp Asp Gln Ala Glu Gly Leu Leu Gly Pro Gly Pro Gln 
            100                 105                 110         


Gly Gln His Gly Cys Arg Glu Gln Leu Glu Leu Phe Gln Xaa Pro Gly 
        115                 120                 125             


Ser Cys Tyr Pro Ala Gln Pro Leu Ser Pro Gly Pro Gln Pro His Asp 
    130                 135                 140                 


Ser Pro Ser Leu Leu Gln Cys Pro Leu Pro Ser Leu Ser Leu Gly Pro 
145                 150                 155                 160 


Ala Val Val Ala Glu Pro Pro Val Gln Leu Ser Pro Ser Pro Leu Leu 
                165                 170                 175     


Phe Ala Ser His Xaa Gly Ser Ser Leu Gln Gly Ser Ser Ser Lys Leu 
            180                 185                 190         


Ser Ala Leu Gln Pro Ser Leu Xaa Ala Gln Xaa Ala Pro Pro Gln Pro 
        195                 200                 205             


Leu Glu Leu Glu His Pro Xaa Arg Gly Lys Leu Gly Ser Ser Pro Asp 
    210                 215                 220                 


Asn Pro Ser Ser Ala Leu Gly Leu Ala Arg Leu Gln Ser Arg Glu His 
225                 230                 235                 240 


Lys Pro Ala Leu Ser Ala Ala Xaa Trp Gln Gly Leu Val Val Asp Pro 
                245                 250                 255     


Ser Pro His Pro Leu Leu Ala Phe Pro Leu Leu Ser Ser Ala Gln Val 
            260                 265                 270         


His Phe 
        


<210> 3941
<211> 127
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 3941
Met Ser Gln Gly Leu Pro Ala Ala Gly Ser Val Leu Gln Arg Ser Val 
1               5                   10                  15      


Ala Ala Pro Gly Asn Gln Pro Gln Pro Gln Pro Gln Gln Gln Ser Pro 
            20                  25                  30          


Glu Asp Asp Asp Arg Lys Val Arg Arg Arg Glu Lys Asn Arg Val Ala 
        35                  40                  45              


Ala Gln Arg Ser Arg Lys Lys Gln Xaa Gln Lys Ala Asp Lys Leu His 
    50                  55                  60                  


Glu Glu Tyr Glu Ser Leu Glu Gln Glu Asn Xaa Met Leu Arg Arg Glu 
65                  70                  75                  80  


Ile Gly Lys Leu Xaa Glu Glu Leu Lys His Leu Xaa Glu Ala Leu Lys 
                85                  90                  95      


Glu His Glu Lys Met Cys Pro Leu Leu Leu Cys Pro Met Asn Phe Val 
            100                 105                 110         


Pro Val Pro Pro Arg Pro Asp Pro Val Ala Gly Cys Leu Pro Arg 
        115                 120                 125         


<210> 3942
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 3942
Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Phe His Pro Gly 
1               5                   10                  15      


Ser Ser Arg Ala Asn Gly Gly Glu Ala Pro Glu Leu Ala Leu Asp Pro 
            20                  25                  30          


Val Pro Gln Asp Ala Ser Xaa Lys Lys Leu Ser Glu Cys Leu Lys Arg 
        35                  40                  45              


Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile Ala 
    50                  55                  60                  


Ala Val Asp Xaa Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala Ala 
65                  70                  75                  80  


Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala Leu 
                85                  90                  95      


Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Xaa Lys Val 
            100                 105                 110         


Pro Glu Leu Ile Arg Xaa Ile Met Gly Trp Xaa Leu Asp Phe Leu Arg 
        115                 120                 125             


Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Asp Gly Leu 
    130                 135                 140                 


Leu Ser Tyr Phe Gly Xaa Pro Xaa Trp Gln Xaa Val Xaa Ile Phe Val 
145                 150                 155                 160 


Ala Gly Val Leu Xaa Ala Ser Leu Xaa Ile Trp Lys Lys Met Gly 
                165                 170                 175 


<210> 3943
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<400> 3943
Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Pro Xaa Ser Ser 
1               5                   10                  15      


Glu Gln Ile Met Lys Xaa Gly Ala Leu Leu Leu Gln Gly Phe Ile Gln 
            20                  25                  30          


Asp Arg Ala Gly Arg Met Gly Gly Glu Ala Pro Glu Leu Ala Leu Asp 
        35                  40                  45              


Pro Val Pro Gln Asp Ala Ser Xaa Lys Lys Leu Ser Glu Cys Leu Lys 
    50                  55                  60                  


Arg Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile 
65                  70                  75                  80  


Ala Ala Val Asp Xaa Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala 
                85                  90                  95      


Ala Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala 
            100                 105                 110         


Leu Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Gly Val Lys Trp 
        115                 120                 125             


Arg Asp Leu Gly Ser Leu Gln Pro Leu Pro Pro Gly Phe Lys Arg Phe 
    130                 135                 140                 


Xaa Cys Leu Ser Ile Pro Arg Ser Trp Asp Tyr Arg Pro Cys Ala Pro 
145                 150                 155                 160 


Arg Cys Arg Asn 
                


<210> 3944
<211> 192
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<400> 3944
Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Pro Xaa Ser Ser 
1               5                   10                  15      


Glu Gln Ile Met Lys Xaa Gly Ala Leu Leu Leu Gln Gly Phe Ile Gln 
            20                  25                  30          


Asp Arg Ala Gly Arg Met Gly Gly Glu Ala Pro Glu Leu Ala Leu Asp 
        35                  40                  45              


Pro Val Pro Gln Asp Ala Ser Xaa Lys Lys Leu Ser Glu Cys Leu Lys 
    50                  55                  60                  


Arg Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile 
65                  70                  75                  80  


Ala Ala Val Asp Xaa Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala 
                85                  90                  95      


Ala Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala 
            100                 105                 110         


Leu Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Xaa Lys 
        115                 120                 125             


Val Pro Glu Leu Ile Arg Xaa Ile Met Gly Trp Xaa Leu Asp Phe Leu 
    130                 135                 140                 


Arg Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Asp Gly 
145                 150                 155                 160 


Leu Leu Ser Tyr Phe Gly Xaa Pro Xaa Trp Gln Xaa Val Xaa Ile Phe 
                165                 170                 175     


Val Ala Gly Val Leu Xaa Ala Ser Leu Xaa Ile Trp Lys Lys Met Gly 
            180                 185                 190         


<210> 3945
<211> 179
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 3945
Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Pro Xaa Ser Ser 
1               5                   10                  15      


Glu Gln Ile Met Lys Xaa Gly Ala Leu Leu Leu Gln Gly Phe Ile Gln 
            20                  25                  30          


Asp Arg Ala Gly Arg Met Gly Gly Glu Ala Pro Glu Leu Ala Leu Asp 
        35                  40                  45              


Pro Val Pro Gln Asp Ala Ser Xaa Lys Lys Leu Ser Glu Cys Leu Lys 
    50                  55                  60                  


Arg Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile 
65                  70                  75                  80  


Ala Ala Val Asp Xaa Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala 
                85                  90                  95      


Ala Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala 
            100                 105                 110         


Leu Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Xaa Lys 
        115                 120                 125             


Val Pro Glu Leu Ile Arg Xaa Ile Met Gly Trp Xaa Leu Asp Phe Leu 
    130                 135                 140                 


Arg Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Xaa Val 
145                 150                 155                 160 


Xaa Ile Phe Val Ala Gly Val Leu Xaa Ala Ser Leu Xaa Ile Trp Lys 
                165                 170                 175     


Lys Met Gly 
            


<210> 3946
<211> 218
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<400> 3946
Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Pro Xaa Ser Ser 
1               5                   10                  15      


Glu Gln Ile Met Lys Xaa Gly Ala Leu Leu Leu Gln Gly Phe Ile Gln 
            20                  25                  30          


Asp Arg Ala Gly Arg Met Gly Gly Glu Ala Pro Glu Leu Ala Leu Asp 
        35                  40                  45              


Pro Val Pro Gln Asp Ala Ser Xaa Lys Lys Leu Ser Glu Cys Leu Lys 
    50                  55                  60                  


Arg Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile 
65                  70                  75                  80  


Ala Ala Val Asp Xaa Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala 
                85                  90                  95      


Ala Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala 
            100                 105                 110         


Leu Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Xaa Lys 
        115                 120                 125             


Val Pro Glu Leu Ile Arg Xaa Ile Met Gly Trp Xaa Leu Asp Phe Leu 
    130                 135                 140                 


Arg Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Val Arg 
145                 150                 155                 160 


Leu Leu Lys Pro Pro His Pro His His Arg Ala Leu Xaa Xaa Ala Pro 
                165                 170                 175     


Ala Pro Pro Ser Leu Pro Pro Ala Xaa Pro Leu Gly Pro Trp Ala Phe 
            180                 185                 190         


Trp Ser Arg Ser Gln Trp Cys Pro Leu Pro Ile Phe Arg Ser Ser Asp 
        195                 200                 205             


Val Val Tyr Asn Ala Phe Ser Leu Arg Val 
    210                 215             


<210> 3947
<211> 143
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<400> 3947
Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Pro Xaa Ser Ser 
1               5                   10                  15      


Glu Gln Ile Met Lys Xaa Gly Ala Leu Leu Leu Gln Gly Met Ile Ala 
            20                  25                  30          


Ala Val Asp Xaa Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala Ala 
        35                  40                  45              


Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala Leu 
    50                  55                  60                  


Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Xaa Lys Val 
65                  70                  75                  80  


Pro Glu Leu Ile Arg Xaa Ile Met Gly Trp Xaa Leu Asp Phe Leu Arg 
                85                  90                  95      


Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Asp Gly Leu 
            100                 105                 110         


Leu Ser Tyr Phe Gly Xaa Pro Xaa Trp Gln Xaa Val Xaa Ile Phe Val 
        115                 120                 125             


Ala Gly Val Leu Xaa Ala Ser Leu Xaa Ile Trp Lys Lys Met Gly 
    130                 135                 140             


<210> 3948
<211> 41
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<400> 3948
Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Val Ser Ser Arg Ile 
1               5                   10                  15      


Glu Gln Gly Glu Trp Gly Gly Arg His Pro Ser Trp Pro Trp Xaa Arg 
            20                  25                  30          


Cys Leu Arg Met Arg Pro Pro Arg Ser 
        35                  40      


<210> 3949
<211> 140
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<400> 3949
Met Ile Ala Ala Val Asp Xaa Asp Ser Pro Arg Glu Val Phe Phe Arg 
1               5                   10                  15      


Val Ala Ala Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val 
            20                  25                  30          


Val Ala Leu Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys 
        35                  40                  45              


Xaa Lys Val Pro Glu Leu Ile Arg Xaa Ile Met Gly Trp Xaa Leu Asp 
    50                  55                  60                  


Phe Leu Arg Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp 
65                  70                  75                  80  


Val Arg Leu Leu Lys Pro Pro His Pro His His Arg Ala Leu Xaa Xaa 
                85                  90                  95      


Ala Pro Ala Pro Pro Ser Leu Pro Pro Ala Xaa Pro Leu Gly Pro Trp 
            100                 105                 110         


Ala Phe Trp Ser Arg Ser Gln Trp Cys Pro Leu Pro Ile Phe Arg Ser 
        115                 120                 125             


Ser Asp Val Val Tyr Asn Ala Phe Ser Leu Arg Val 
    130                 135                 140 


<210> 3950
<211> 126
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<400> 3950
Xaa Gly Arg Val Arg Gly Ala Ala Gln Arg Arg Gly Met Ile Ala Ala 
1               5                   10                  15      


Val Asp Xaa Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala Ala Asp 
            20                  25                  30          


Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala Leu Phe 
        35                  40                  45              


Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Xaa Lys Val Pro 
    50                  55                  60                  


Glu Leu Ile Arg Xaa Ile Met Gly Trp Xaa Leu Asp Phe Leu Arg Glu 
65                  70                  75                  80  


Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Asp Gly Leu Leu 
                85                  90                  95      


Ser Tyr Phe Gly Xaa Pro Xaa Trp Gln Xaa Val Xaa Ile Phe Val Ala 
            100                 105                 110         


Gly Val Leu Xaa Ala Ser Leu Xaa Ile Trp Lys Lys Met Gly 
        115                 120                 125     


<210> 3951
<211> 1524
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1103)..(1103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1152)..(1152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1270)..(1270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1273)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1294)..(1294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1304)..(1304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1388)..(1388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1481)..(1481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1488)..(1488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1515)..(1515)
<223> Selenocysteine

<400> 3951
Met Pro Leu Leu His Arg Lys Pro Phe Val Arg Gln Lys Pro Pro Ala 
1               5                   10                  15      


Asp Leu Arg Pro Asp Glu Glu Val Phe Tyr Cys Lys Val Xaa Asn Glu 
            20                  25                  30          


Ile Phe Arg His Tyr Asp Asp Phe Phe Glu Arg Xaa Ile Leu Cys Asn 
        35                  40                  45              


Ser Leu Val Trp Ser Cys Ala Val Xaa Gly Arg Pro Gly Leu Xaa Tyr 
    50                  55                  60                  


Gln Glu Ala Leu Glu Ser Glu Lys Lys Ala Arg Gln Asn Leu Gln Ser 
65                  70                  75                  80  


Phe Pro Glu Pro Leu Ile Ile Pro Val Leu Tyr Leu Xaa Ser Leu Xaa 
                85                  90                  95      


His Arg Ser Arg Leu His Glu Ile Cys Asp Asp Ile Phe Ala Tyr Val 
            100                 105                 110         


Lys Asp Arg Tyr Phe Val Glu Glu Xaa Val Glu Val Ile Arg Asn Asn 
        115                 120                 125             


Gly Ala Arg Leu Gln Cys Arg Ile Leu Glu Val Leu Pro Pro Ser His 
    130                 135                 140                 


Gln Asn Gly Phe Ala Asn Gly His Val Asn Ser Val Asp Gly Glu Xaa 
145                 150                 155                 160 


Ile Ile Ile Ser Asp Ser Asp Asp Ser Glu Xaa Gln Ser Cys Ser Phe 
                165                 170                 175     


Gln Asn Gly Lys Lys Lys Asp Ala Ile Asp Pro Leu Leu Phe Lys Tyr 
            180                 185                 190         


Lys Val Gln Pro Xaa Lys Lys Glu Leu His Glu Ser Ala Ile Val Lys 
        195                 200                 205             


Ala Xaa Gln Ile Ser Arg Arg Lys His Leu Phe Ser Arg Asp Lys Leu 
    210                 215                 220                 


Lys Leu Phe Leu Lys Gln His Cys Glu Pro Gln Asp Gly Val Ile Lys 
225                 230                 235                 240 


Ile Lys Ala Ser Ser Leu Ser Xaa Tyr Lys Ile Ala Glu Gln Asp Phe 
                245                 250                 255     


Ser Tyr Phe Phe Pro Asp Asp Pro Pro Xaa Phe Ile Phe Ser Pro Ala 
            260                 265                 270         


Asn Arg Arg Arg Gly Arg Pro Pro Lys Arg Ile His Ile Ser Gln Glu 
        275                 280                 285             


Asp Asn Val Ala Asn Lys Gln Xaa Leu Ala Ser Tyr Arg Ser Lys Ala 
    290                 295                 300                 


Xaa Lys Glu Arg Asp Lys Leu Leu Lys Gln Glu Glu Met Lys Ser Leu 
305                 310                 315                 320 


Ala Phe Glu Lys Ala Lys Leu Lys Arg Glu Lys Ala Asp Ala Leu Glu 
                325                 330                 335     


Ala Lys Lys Lys Glu Lys Glu Asp Lys Glu Lys Lys Arg Glu Glu Leu 
            340                 345                 350         


Lys Lys Ile Val Glu Glu Glu Arg Leu Lys Lys Lys Glu Glu Lys Glu 
        355                 360                 365             


Arg Leu Lys Val Glu Arg Glu Lys Glu Arg Glu Lys Leu Arg Glu Glu 
    370                 375                 380                 


Lys Arg Lys Tyr Val Glu Tyr Leu Lys Gln Trp Ser Lys Pro Arg Glu 
385                 390                 395                 400 


Asp Met Glu Cys Asp Asp Leu Lys Glu Leu Pro Glu Pro Xaa Pro Val 
                405                 410                 415     


Lys Xaa Arg Leu Pro Pro Glu Ile Phe Gly Asp Ala Leu Met Val Leu 
            420                 425                 430         


Glu Phe Leu Asn Ala Phe Gly Glu Leu Phe Asp Leu Gln Asp Glu Phe 
        435                 440                 445             


Pro Asp Gly Val Xaa Leu Glu Val Leu Glu Glu Ala Leu Val Gly Asn 
    450                 455                 460                 


Asp Ser Glu Gly Pro Leu Cys Glu Leu Leu Phe Phe Phe Leu Xaa Ala 
465                 470                 475                 480 


Ile Phe Gln Ala Ile Ala Glu Glu Glu Glu Glu Val Ala Lys Glu Gln 
                485                 490                 495     


Leu Xaa Asp Ala Asp Xaa Lys Gly Cys Ser Leu Lys Ser Leu Asp Leu 
            500                 505                 510         


Asp Ser Cys Xaa Leu Ser Glu Ile Leu Arg Leu His Ile Leu Ala Ser 
        515                 520                 525             


Gly Ala Asp Val Xaa Ser Ala Asn Ala Lys Tyr Arg Tyr Gln Lys Arg 
    530                 535                 540                 


Gly Gly Phe Asp Ala Xaa Asp Asp Ala Cys Met Glu Leu Arg Leu Ser 
545                 550                 555                 560 


Asn Pro Ser Leu Val Lys Lys Leu Ser Ser Xaa Ser Val Tyr Asp Leu 
                565                 570                 575     


Xaa Pro Gly Glu Lys Met Lys Ile Leu His Ala Leu Cys Gly Lys Leu 
            580                 585                 590         


Leu Xaa Leu Val Ser Xaa Arg Asp Phe Ile Glu Asp Tyr Val Asp Ile 
        595                 600                 605             


Leu Arg Gln Ala Lys Gln Glu Phe Arg Glu Leu Lys Ala Glu Gln His 
    610                 615                 620                 


Arg Lys Glu Arg Glu Glu Ala Ala Ala Arg Ile Arg Lys Arg Lys Glu 
625                 630                 635                 640 


Glu Lys Leu Lys Glu Gln Glu Gln Lys Met Lys Glu Lys Gln Glu Lys 
                645                 650                 655     


Leu Lys Glu Asp Glu Gln Arg Asn Ser Xaa Ala Asp Ile Ser Ile Gly 
            660                 665                 670         


Glu Glu Glu Arg Glu Asp Phe Asp Xaa Ser Ile Glu Ser Lys Asp Xaa 
        675                 680                 685             


Glu Gln Lys Glu Leu Asp Gln Asp Met Val Xaa Glu Asp Glu Asp Asp 
    690                 695                 700                 


Pro Gly Ser His Lys Arg Gly Arg Arg Gly Lys Arg Gly Gln Asn Gly 
705                 710                 715                 720 


Phe Lys Glu Phe Xaa Arg Gln Glu Gln Ile Asn Cys Val Xaa Arg Glu 
                725                 730                 735     


Pro Leu Xaa Ala Asp Glu Glu Glu Ala Leu Lys Gln Glu His Gln Arg 
            740                 745                 750         


Lys Glu Lys Glu Leu Leu Glu Lys Ile Gln Ser Ala Ile Ala Cys Xaa 
        755                 760                 765             


Asn Ile Phe Pro Leu Gly Arg Asp Arg Met Tyr Arg Arg Tyr Trp Ile 
    770                 775                 780                 


Phe Pro Ser Ile Pro Gly Leu Phe Ile Glu Glu Asp Tyr Ser Gly Leu 
785                 790                 795                 800 


Xaa Glu Asp Met Leu Leu Pro Arg Pro Ser Ser Phe Gln Asn Asn Val 
                805                 810                 815     


Gln Ser Gln Asp Pro Gln Val Ser Xaa Lys Xaa Gly Glu Pro Leu Met 
            820                 825                 830         


Ser Glu Ser Xaa Ser Asn Ile Asp Gln Gly Pro Arg Asp His Ser Val 
        835                 840                 845             


Gln Leu Pro Lys Pro Val His Lys Pro Asn Arg Trp Cys Phe Tyr Ser 
    850                 855                 860                 


Ser Cys Glu Gln Leu Asp Gln Leu Ile Glu Ala Leu Asn Ser Arg Gly 
865                 870                 875                 880 


His Arg Glu Ser Ala Leu Lys Glu Xaa Leu Leu Gln Glu Lys Ser Arg 
                885                 890                 895     


Ile Cys Ala Gln Leu Ala Arg Phe Ser Glu Glu Lys Phe His Phe Ser 
            900                 905                 910         


Asp Lys Pro Gln Pro Asp Ser Lys Pro Xaa Tyr Ser Arg Gly Arg Ser 
        915                 920                 925             


Ser Asn Ala Tyr Asp Pro Ser Gln Met Cys Ala Glu Lys Gln Leu Glu 
    930                 935                 940                 


Leu Arg Leu Arg Asp Phe Leu Leu Asp Ile Glu Asp Arg Ile Tyr Gln 
945                 950                 955                 960 


Gly Xaa Leu Gly Ala Ile Lys Val Xaa Asp Arg His Ile Trp Arg Ser 
                965                 970                 975     


Ala Leu Glu Ser Gly Arg Tyr Glu Leu Leu Ser Glu Glu Asn Lys Glu 
            980                 985                 990         


Asn Gly Ile Ile Lys Xaa Val Asn  Glu Asp Val Glu Glu  Met Glu Ile 
        995                 1000                 1005             


Asp Glu  Gln Xaa Lys Val Ile  Val Lys Asp Arg Leu  Leu Gly Ile 
    1010                 1015                 1020             


Lys Xaa  Glu Xaa Pro Ser Xaa  Val Ser Xaa Asn Ala  Ser Xaa Pro 
    1025                 1030                 1035             


Gln Ser  Val Ser Ser Val Val  His Tyr Leu Ala Met  Ala Leu Phe 
    1040                 1045                 1050             


Gln Ile  Glu Gln Gly Ile Glu  Arg Arg Phe Leu Lys  Ala Pro Leu 
    1055                 1060                 1065             


Asp Ala  Ser Asp Ser Gly Arg  Ser Tyr Lys Xaa Val  Leu Asp Arg 
    1070                 1075                 1080             


Trp Arg  Glu Ser Leu Leu Ser  Ser Ala Ser Leu Ser  Gln Val Phe 
    1085                 1090                 1095             


Leu His  Leu Ser Xaa Leu Asp  Arg Ser Val Ile Trp  Ser Lys Ser 
    1100                 1105                 1110             


Ile Leu  Asn Ala Arg Cys Lys  Ile Cys Arg Lys Lys  Gly Asp Ala 
    1115                 1120                 1125             


Glu Asn  Met Val Leu Cys Asp  Gly Cys Asp Arg Gly  His His Xaa 
    1130                 1135                 1140             


Tyr Cys  Val Arg Pro Lys Leu  Lys Xaa Val Pro Glu  Gly Asp Trp 
    1145                 1150                 1155             


Phe Cys  Pro Glu Cys Arg Pro  Lys Gln Arg Ser Arg  Arg Leu Ser 
    1160                 1165                 1170             


Ser Arg  Gln Arg Pro Ser Leu  Glu Ser Asp Glu Asp  Val Glu Asp 
    1175                 1180                 1185             


Ser Met  Gly Gly Glu Asp Asp  Glu Val Asp Gly Asp  Glu Glu Glu 
    1190                 1195                 1200             


Gly Gln  Ser Glu Glu Glu Glu  Tyr Glu Val Glu Gln  Asp Glu Asp 
    1205                 1210                 1215             


Asp Ser  Gln Glu Glu Glu Glu  Val Ser Leu Pro Lys  Arg Gly Arg 
    1220                 1225                 1230             


Pro Gln  Val Arg Leu Pro Val  Lys Xaa Arg Gly Lys  Leu Ser Ser 
    1235                 1240                 1245             


Ser Phe  Ser Ser Arg Gly Gln  Gln Gln Glu Pro Gly  Arg Tyr Pro 
    1250                 1255                 1260             


Ser Arg  Ser Gln Gln Ser Xaa  Pro Lys Xaa Xaa Val  Ser Ser Lys 
    1265                 1270                 1275             


Xaa Gly  Arg Ser Leu Arg Lys  Ile Asn Ser Ala Pro  Pro Xaa Glu 
    1280                 1285                 1290             


Xaa Lys  Ser Leu Arg Ile Ala  Ser Arg Ser Xaa Arg  His Ser His 
    1295                 1300                 1305             


Gly Pro  Leu Gln Ala Asp Val  Phe Val Glu Leu Leu  Ser Pro Arg 
    1310                 1315                 1320             


Arg Lys  Arg Arg Gly Arg Lys  Ser Ala Asn Asn Xaa  Pro Glu Asn 
    1325                 1330                 1335             


Ser Pro  Asn Phe Pro Asn Phe  Arg Val Ile Ala Xaa  Lys Ser Ser 
    1340                 1345                 1350             


Glu Gln  Ser Arg Ser Val Asn  Ile Ala Ser Lys Leu  Ser Leu Gln 
    1355                 1360                 1365             


Glu Ser  Glu Ser Lys Arg Arg  Cys Arg Lys Arg Gln  Ser Pro Glu 
    1370                 1375                 1380             


Pro Ser  Pro Val Xaa Leu Gly  Arg Arg Ser Ser Gly  Arg Gln Gly 
    1385                 1390                 1395             


Gly Val  His Glu Leu Ser Ala  Phe Glu Gln Leu Val  Val Glu Leu 
    1400                 1405                 1410             


Val Arg  His Asp Asp Ser Trp  Pro Phe Leu Lys Leu  Val Ser Lys 
    1415                 1420                 1425             


Ile Gln  Val Pro Asp Tyr Tyr  Asp Ile Ile Lys Lys  Pro Ile Ala 
    1430                 1435                 1440             


Leu Asn  Ile Ile Arg Glu Lys  Val Asn Lys Cys Glu  Tyr Lys Leu 
    1445                 1450                 1455             


Ala Ser  Glu Phe Ile Asp Asp  Ile Glu Leu Met Phe  Ser Asn Cys 
    1460                 1465                 1470             


Phe Glu  Tyr Asn Pro Arg Asn  Xaa Ser Glu Ala Lys  Ala Gly Xaa 
    1475                 1480                 1485             


Arg Leu  Gln Ala Phe Phe His  Ile Gln Ala Gln Lys  Leu Gly Leu 
    1490                 1495                 1500             


His Val  Xaa Pro Ser Asn Val  Asp Gln Val Ser Xaa  Pro Pro Ala 
    1505                 1510                 1515             


Ala Lys  Lys Ser Arg Ile 
    1520                 


<210> 3952
<211> 1556
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1184)..(1184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1324)..(1324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1367)..(1367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1382)..(1382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1520)..(1520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1538)..(1538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<400> 3952
Met Pro Leu Leu His Arg Lys Pro Phe Val Arg Gln Lys Pro Pro Ala 
1               5                   10                  15      


Asp Leu Arg Pro Asp Glu Glu Val Phe Tyr Cys Lys Val Xaa Asn Glu 
            20                  25                  30          


Ile Phe Arg His Tyr Asp Asp Phe Phe Glu Arg Xaa Ile Leu Cys Asn 
        35                  40                  45              


Ser Leu Val Trp Ser Cys Ala Val Xaa Gly Arg Pro Gly Leu Xaa Tyr 
    50                  55                  60                  


Gln Glu Ala Leu Glu Ser Glu Lys Lys Ala Arg Gln Asn Leu Gln Ser 
65                  70                  75                  80  


Phe Pro Glu Pro Leu Ile Ile Pro Val Leu Tyr Leu Xaa Ser Leu Xaa 
                85                  90                  95      


His Arg Ser Arg Leu His Glu Ile Cys Asp Asp Ile Phe Ala Tyr Val 
            100                 105                 110         


Lys Asp Arg Tyr Phe Val Glu Glu Xaa Val Glu Val Ile Arg Asn Asn 
        115                 120                 125             


Gly Ala Arg Leu Gln Cys Arg Ile Leu Glu Val Leu Pro Pro Ser His 
    130                 135                 140                 


Gln Asn Gly Phe Ala Asn Gly His Val Asn Ser Val Asp Gly Glu Xaa 
145                 150                 155                 160 


Ile Ile Ile Ser Asp Ser Asp Asp Ser Glu Xaa Gln Ser Cys Ser Phe 
                165                 170                 175     


Gln Asn Gly Lys Lys Lys Asp Ala Ile Asp Pro Leu Leu Phe Lys Tyr 
            180                 185                 190         


Lys Val Gln Pro Xaa Lys Lys Glu Leu His Glu Ser Ala Ile Val Lys 
        195                 200                 205             


Ala Xaa Gln Ile Ser Arg Arg Lys His Leu Phe Ser Arg Asp Lys Leu 
    210                 215                 220                 


Lys Leu Phe Leu Lys Gln His Cys Glu Pro Gln Asp Gly Val Ile Lys 
225                 230                 235                 240 


Ile Lys Ala Ser Ser Leu Ser Xaa Tyr Lys Ile Ala Glu Gln Asp Phe 
                245                 250                 255     


Ser Tyr Phe Phe Pro Asp Asp Pro Pro Xaa Phe Ile Phe Ser Pro Ala 
            260                 265                 270         


Asn Arg Arg Arg Gly Arg Pro Pro Lys Arg Ile His Ile Ser Gln Glu 
        275                 280                 285             


Asp Asn Val Ala Asn Lys Gln Xaa Leu Ala Ser Tyr Arg Ser Lys Ala 
    290                 295                 300                 


Xaa Lys Glu Arg Asp Lys Leu Leu Lys Gln Glu Glu Met Lys Ser Leu 
305                 310                 315                 320 


Ala Phe Glu Lys Ala Lys Leu Lys Arg Glu Lys Ala Asp Ala Leu Glu 
                325                 330                 335     


Ala Lys Lys Lys Glu Lys Glu Asp Lys Glu Lys Lys Arg Glu Glu Leu 
            340                 345                 350         


Lys Lys Ile Val Glu Glu Glu Arg Leu Lys Lys Lys Glu Glu Lys Glu 
        355                 360                 365             


Arg Leu Lys Val Glu Arg Glu Lys Glu Arg Glu Lys Leu Arg Glu Glu 
    370                 375                 380                 


Lys Arg Lys Tyr Val Glu Tyr Leu Lys Gln Trp Ser Lys Pro Arg Glu 
385                 390                 395                 400 


Asp Met Glu Cys Asp Asp Leu Lys Glu Leu Pro Glu Pro Xaa Pro Val 
                405                 410                 415     


Lys Xaa Arg Leu Pro Pro Glu Ile Phe Gly Asp Ala Leu Met Val Leu 
            420                 425                 430         


Glu Phe Leu Asn Ala Phe Gly Glu Leu Phe Asp Leu Gln Asp Glu Phe 
        435                 440                 445             


Pro Asp Gly Val Xaa Leu Glu Val Leu Glu Glu Ala Leu Val Gly Asn 
    450                 455                 460                 


Asp Ser Glu Gly Pro Leu Cys Glu Leu Leu Phe Phe Phe Leu Xaa Ala 
465                 470                 475                 480 


Ile Phe Gln Ala Ile Ala Glu Glu Glu Glu Glu Val Ala Lys Glu Gln 
                485                 490                 495     


Leu Xaa Asp Ala Asp Xaa Lys Asp Leu Xaa Glu Ala Leu Asp Glu Asp 
            500                 505                 510         


Ala Asp Pro Xaa Lys Ser Ala Leu Ser Ala Val Ala Ser Leu Ala Ala 
        515                 520                 525             


Ala Trp Pro Gln Leu His Gln Gly Cys Ser Leu Lys Ser Leu Asp Leu 
    530                 535                 540                 


Asp Ser Cys Xaa Leu Ser Glu Ile Leu Arg Leu His Ile Leu Ala Ser 
545                 550                 555                 560 


Gly Ala Asp Val Xaa Ser Ala Asn Ala Lys Tyr Arg Tyr Gln Lys Arg 
                565                 570                 575     


Gly Gly Phe Asp Ala Xaa Asp Asp Ala Cys Met Glu Leu Arg Leu Ser 
            580                 585                 590         


Asn Pro Ser Leu Val Lys Lys Leu Ser Ser Xaa Ser Val Tyr Asp Leu 
        595                 600                 605             


Xaa Pro Gly Glu Lys Met Lys Ile Leu His Ala Leu Cys Gly Lys Leu 
    610                 615                 620                 


Leu Xaa Leu Val Ser Xaa Arg Asp Phe Ile Glu Asp Tyr Val Asp Ile 
625                 630                 635                 640 


Leu Arg Gln Ala Lys Gln Glu Phe Arg Glu Leu Lys Ala Glu Gln His 
                645                 650                 655     


Arg Lys Glu Arg Glu Glu Ala Ala Ala Arg Ile Arg Lys Arg Lys Glu 
            660                 665                 670         


Glu Lys Leu Lys Glu Gln Glu Gln Lys Met Lys Glu Lys Gln Glu Lys 
        675                 680                 685             


Leu Lys Glu Asp Glu Gln Arg Asn Ser Xaa Ala Asp Ile Ser Ile Gly 
    690                 695                 700                 


Glu Glu Glu Arg Glu Asp Phe Asp Xaa Ser Ile Glu Ser Lys Asp Xaa 
705                 710                 715                 720 


Glu Gln Lys Glu Leu Asp Gln Asp Met Val Xaa Glu Asp Glu Asp Asp 
                725                 730                 735     


Pro Gly Ser His Lys Arg Gly Arg Arg Gly Lys Arg Gly Gln Asn Gly 
            740                 745                 750         


Phe Lys Glu Phe Xaa Arg Gln Glu Gln Ile Asn Cys Val Xaa Arg Glu 
        755                 760                 765             


Pro Leu Xaa Ala Asp Glu Glu Glu Ala Leu Lys Gln Glu His Gln Arg 
    770                 775                 780                 


Lys Glu Lys Glu Leu Leu Glu Lys Ile Gln Ser Ala Ile Ala Cys Xaa 
785                 790                 795                 800 


Asn Ile Phe Pro Leu Gly Arg Asp Arg Met Tyr Arg Arg Tyr Trp Ile 
                805                 810                 815     


Phe Pro Ser Ile Pro Gly Leu Phe Ile Glu Glu Asp Tyr Ser Gly Leu 
            820                 825                 830         


Xaa Glu Asp Met Leu Leu Pro Arg Pro Ser Ser Phe Gln Asn Asn Val 
        835                 840                 845             


Gln Ser Gln Asp Pro Gln Val Ser Xaa Lys Xaa Gly Glu Pro Leu Met 
    850                 855                 860                 


Ser Glu Ser Xaa Ser Asn Ile Asp Gln Gly Pro Arg Asp His Ser Val 
865                 870                 875                 880 


Gln Leu Pro Lys Pro Val His Lys Pro Asn Arg Trp Cys Phe Tyr Ser 
                885                 890                 895     


Ser Cys Glu Gln Leu Asp Gln Leu Ile Glu Ala Leu Asn Ser Arg Gly 
            900                 905                 910         


His Arg Glu Ser Ala Leu Lys Glu Xaa Leu Leu Gln Glu Lys Ser Arg 
        915                 920                 925             


Ile Cys Ala Gln Leu Ala Arg Phe Ser Glu Glu Lys Phe His Phe Ser 
    930                 935                 940                 


Asp Lys Pro Gln Pro Asp Ser Lys Pro Xaa Tyr Ser Arg Gly Arg Ser 
945                 950                 955                 960 


Ser Asn Ala Tyr Asp Pro Ser Gln Met Cys Ala Glu Lys Gln Leu Glu 
                965                 970                 975     


Leu Arg Leu Arg Asp Phe Leu Leu Asp Ile Glu Asp Arg Ile Tyr Gln 
            980                 985                 990         


Gly Xaa Leu Gly Ala Ile Lys Val  Xaa Asp Arg His Ile  Trp Arg Ser 
        995                 1000                 1005             


Ala Leu  Glu Ser Gly Arg Tyr  Glu Leu Leu Ser Glu  Glu Asn Lys 
    1010                 1015                 1020             


Glu Asn  Gly Ile Ile Lys Xaa  Val Asn Glu Asp Val  Glu Glu Met 
    1025                 1030                 1035             


Glu Ile  Asp Glu Gln Xaa Lys  Val Ile Val Lys Asp  Arg Leu Leu 
    1040                 1045                 1050             


Gly Ile  Lys Xaa Glu Xaa Pro  Ser Xaa Val Ser Xaa  Asn Ala Ser 
    1055                 1060                 1065             


Xaa Pro  Gln Ser Val Ser Ser  Val Val His Tyr Leu  Ala Met Ala 
    1070                 1075                 1080             


Leu Phe  Gln Ile Glu Gln Gly  Ile Glu Arg Arg Phe  Leu Lys Ala 
    1085                 1090                 1095             


Pro Leu  Asp Ala Ser Asp Ser  Gly Arg Ser Tyr Lys  Xaa Val Leu 
    1100                 1105                 1110             


Asp Arg  Trp Arg Glu Ser Leu  Leu Ser Ser Ala Ser  Leu Ser Gln 
    1115                 1120                 1125             


Val Phe  Leu His Leu Ser Xaa  Leu Asp Arg Ser Val  Ile Trp Ser 
    1130                 1135                 1140             


Lys Ser  Ile Leu Asn Ala Arg  Cys Lys Ile Cys Arg  Lys Lys Gly 
    1145                 1150                 1155             


Asp Ala  Glu Asn Met Val Leu  Cys Asp Gly Cys Asp  Arg Gly His 
    1160                 1165                 1170             


His Xaa  Tyr Cys Val Arg Pro  Lys Leu Lys Xaa Val  Pro Glu Gly 
    1175                 1180                 1185             


Asp Trp  Phe Cys Pro Glu Cys  Arg Pro Lys Gln Arg  Ser Arg Arg 
    1190                 1195                 1200             


Leu Ser  Ser Arg Gln Arg Pro  Ser Leu Glu Ser Asp  Glu Asp Val 
    1205                 1210                 1215             


Glu Asp  Ser Met Gly Gly Glu  Asp Asp Glu Val Asp  Gly Asp Glu 
    1220                 1225                 1230             


Glu Glu  Gly Gln Ser Glu Glu  Glu Glu Tyr Glu Val  Glu Gln Asp 
    1235                 1240                 1245             


Glu Asp  Asp Ser Gln Glu Glu  Glu Glu Val Ser Leu  Pro Lys Arg 
    1250                 1255                 1260             


Gly Arg  Pro Gln Val Arg Leu  Pro Val Lys Xaa Arg  Gly Lys Leu 
    1265                 1270                 1275             


Ser Ser  Ser Phe Ser Ser Arg  Gly Gln Gln Gln Glu  Pro Gly Arg 
    1280                 1285                 1290             


Tyr Pro  Ser Arg Ser Gln Gln  Ser Xaa Pro Lys Xaa  Xaa Val Ser 
    1295                 1300                 1305             


Ser Lys  Xaa Gly Arg Ser Leu  Arg Lys Ile Asn Ser  Ala Pro Pro 
    1310                 1315                 1320             


Xaa Glu  Xaa Lys Ser Leu Arg  Ile Ala Ser Arg Ser  Xaa Arg His 
    1325                 1330                 1335             


Ser His  Gly Pro Leu Gln Ala  Asp Val Phe Val Glu  Leu Leu Ser 
    1340                 1345                 1350             


Pro Arg  Arg Lys Arg Arg Gly  Arg Lys Ser Ala Asn  Asn Xaa Pro 
    1355                 1360                 1365             


Glu Asn  Ser Pro Asn Phe Pro  Asn Phe Arg Val Ile  Ala Xaa Lys 
    1370                 1375                 1380             


Ser Ser  Glu Gln Ser Arg Ser  Val Asn Ile Ala Ser  Lys Leu Ser 
    1385                 1390                 1395             


Leu Gln  Glu Ser Glu Ser Lys  Arg Arg Cys Arg Lys  Arg Gln Ser 
    1400                 1405                 1410             


Pro Glu  Pro Ser Pro Val Xaa  Leu Gly Arg Arg Ser  Ser Gly Arg 
    1415                 1420                 1425             


Gln Gly  Gly Val His Glu Leu  Ser Ala Phe Glu Gln  Leu Val Val 
    1430                 1435                 1440             


Glu Leu  Val Arg His Asp Asp  Ser Trp Pro Phe Leu  Lys Leu Val 
    1445                 1450                 1455             


Ser Lys  Ile Gln Val Pro Asp  Tyr Tyr Asp Ile Ile  Lys Lys Pro 
    1460                 1465                 1470             


Ile Ala  Leu Asn Ile Ile Arg  Glu Lys Val Asn Lys  Cys Glu Tyr 
    1475                 1480                 1485             


Lys Leu  Ala Ser Glu Phe Ile  Asp Asp Ile Glu Leu  Met Phe Ser 
    1490                 1495                 1500             


Asn Cys  Phe Glu Tyr Asn Pro  Arg Asn Xaa Ser Glu  Ala Lys Ala 
    1505                 1510                 1515             


Gly Xaa  Arg Leu Gln Ala Phe  Phe His Ile Gln Ala  Gln Lys Leu 
    1520                 1525                 1530             


Gly Leu  His Val Xaa Pro Ser  Asn Val Asp Gln Val  Ser Xaa Pro 
    1535                 1540                 1545             


Pro Ala  Ala Lys Lys Ser Arg  Ile 
    1550                 1555     


<210> 3953
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 3953
Xaa Leu Leu Gly Ile Lys Xaa Glu Xaa Pro Ser Xaa Val Ser Xaa Asn 
1               5                   10                  15      


Ala Ser Xaa Pro Gln Ser Val Ser Ser Val Val His Tyr Leu Ala Met 
            20                  25                  30          


Ala Leu Phe Gln Ile Glu Gln Gly Ile Glu Arg Arg Phe Leu Lys Ala 
        35                  40                  45              


Pro Leu Gly Lys Xaa Glu Ile Asn Lys Asp Gln Lys Gly Asp Arg Lys 
    50                  55                  60                  


Lys Lys Gly Gln Glu Lys Glu Arg Gly Arg Ser Ile 
65                  70                  75      


<210> 3954
<211> 12
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 3954
Xaa Arg Lys Arg Gln Ser Pro Gly Pro Arg Leu Leu 
1               5                   10          


<210> 3955
<211> 218
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<400> 3955
Xaa Ser Cys Xaa Leu Ser Glu Ile Leu Arg Leu His Ile Leu Ala Ser 
1               5                   10                  15      


Gly Ala Asp Val Xaa Ser Ala Asn Ala Lys Tyr Arg Tyr Gln Lys Arg 
            20                  25                  30          


Gly Gly Phe Asp Ala Xaa Asp Asp Ala Cys Met Glu Leu Arg Leu Ser 
        35                  40                  45              


Asn Pro Ser Leu Val Lys Lys Leu Ser Ser Xaa Ser Val Tyr Asp Leu 
    50                  55                  60                  


Xaa Pro Gly Glu Lys Met Lys Ile Leu His Ala Leu Cys Gly Lys Leu 
65                  70                  75                  80  


Leu Xaa Leu Val Ser Xaa Arg Asp Phe Ile Glu Asp Tyr Val Asp Ile 
                85                  90                  95      


Leu Arg Gln Ala Lys Gln Glu Phe Arg Glu Leu Lys Ala Glu Gln His 
            100                 105                 110         


Arg Lys Glu Arg Glu Glu Ala Ala Ala Arg Ile Arg Lys Arg Lys Glu 
        115                 120                 125             


Glu Lys Leu Lys Glu Gln Glu Gln Lys Met Lys Glu Lys Gln Glu Lys 
    130                 135                 140                 


Leu Lys Glu Asp Glu Gln Arg Asn Ser Xaa Ala Asp Ile Ser Ile Gly 
145                 150                 155                 160 


Glu Glu Glu Arg Glu Asp Phe Asp Xaa Ser Ile Glu Ser Lys Asp Xaa 
                165                 170                 175     


Glu Gln Lys Glu Leu Asp Gln Asp Met Val Xaa Glu Asp Glu Asp Asp 
            180                 185                 190         


Pro Gly Ser His Lys Arg Gly Arg Arg Gly Asn Xaa Glu Ile Ser Leu 
        195                 200                 205             


Gly His Ser Cys Val Phe Val Phe Asn Gln 
    210                 215             


<210> 3956
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<400> 3956
Xaa Tyr Val Lys Asp Arg Tyr Phe Val Glu Glu Xaa Val Glu Val Ile 
1               5                   10                  15      


Arg Asn Asn Gly Ala Arg Leu Gln Cys Arg Ile Leu Glu Val Leu Pro 
            20                  25                  30          


Pro Ser His Gln Asn Gly Phe Ala Asn Gly His Val Asn Ser Val Asp 
        35                  40                  45              


Gly Glu Xaa Ile Ile Ile Ser Asp Ser Asp Asp Ser Glu Xaa Gln Ser 
    50                  55                  60                  


Cys Ser Phe Gln Asn Gly Phe Pro Leu Leu Xaa Ala Lys 
65                  70                  75          


<210> 3957
<211> 1483
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1161)..(1161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1235)..(1235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1246)..(1246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1287)..(1287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1369)..(1369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1388)..(1388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1406)..(1406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1413)..(1413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1432)..(1432)
<223> Selenocysteine

<400> 3957
Met Ala Pro Leu Leu Gly Arg Lys Pro Phe Pro Leu Val Lys Pro Leu 
1               5                   10                  15      


Pro Gly Glu Glu Pro Leu Phe Xaa Ile Pro His Xaa Gln Glu Ala Phe 
            20                  25                  30          


Arg Xaa Arg Glu Glu Tyr Glu Ala Arg Leu Glu Arg Tyr Ser Glu Arg 
        35                  40                  45              


Ile Trp Xaa Cys Lys Ser Xaa Gly Ser Ser Gln Leu Xaa His Lys Glu 
    50                  55                  60                  


Ala Trp Glu Glu Glu Gln Glu Val Ala Glu Leu Leu Lys Glu Glu Phe 
65                  70                  75                  80  


Pro Ala Trp Tyr Glu Lys Leu Val Leu Glu Met Val His His Asn Xaa 
                85                  90                  95      


Ala Ser Leu Glu Lys Leu Val Asp Xaa Ala Trp Leu Glu Ile Met Xaa 
            100                 105                 110         


Lys Tyr Ala Val Gly Glu Glu Cys Asp Phe Glu Val Gly Lys Glu Lys 
        115                 120                 125             


Met Leu Lys Val Lys Ile Val Lys Ile His Pro Leu Glu Lys Val Asp 
    130                 135                 140                 


Glu Glu Ala Xaa Glu Lys Lys Ser Asp Gly Ala Cys Asp Ser Pro Ser 
145                 150                 155                 160 


Ser Asp Lys Glu Asn Ser Ser Gln Ile Ala Gln Asp His Gln Lys Lys 
                165                 170                 175     


Glu Xaa Val Val Lys Glu Asp Glu Gly Arg Arg Glu Ser Ile Asn Asp 
            180                 185                 190         


Arg Ala Arg Arg Ser Pro Arg Lys Leu Pro Xaa Ser Leu Lys Lys Gly 
        195                 200                 205             


Glu Arg Lys Trp Ala Pro Pro Lys Phe Leu Pro His Lys Tyr Asp Val 
    210                 215                 220                 


Lys Leu Gln Asn Glu Asp Lys Ile Ile Ser Asn Val Pro Ala Asp Ser 
225                 230                 235                 240 


Leu Ile Arg Xaa Glu Arg Pro Pro Asn Lys Glu Ile Val Arg Tyr Phe 
                245                 250                 255     


Ile Arg His Asn Ala Leu Arg Ala Gly Xaa Gly Glu Asn Ala Pro Trp 
            260                 265                 270         


Val Val Glu Asp Glu Leu Val Lys Lys Tyr Ser Leu Pro Ser Lys Phe 
        275                 280                 285             


Ser Asp Phe Leu Leu Asp Pro Tyr Lys Tyr Met Xaa Leu Asn Pro Ser 
    290                 295                 300                 


Xaa Lys Arg Lys Asn Xaa Gly Ser Pro Asp Arg Lys Pro Ser Lys Lys 
305                 310                 315                 320 


Ser Lys Xaa Asp Asn Ser Ser Leu Ser Ser Pro Leu Asn Pro Lys Leu 
                325                 330                 335     


Trp Cys His Val His Leu Lys Lys Ser Leu Ser Gly Ser Pro Leu Lys 
            340                 345                 350         


Val Lys Asn Ser Lys Asn Ser Lys Ser Pro Glu Glu His Leu Glu Glu 
        355                 360                 365             


Met Met Lys Met Met Ser Pro Asn Lys Leu His Xaa Asn Phe His Ile 
    370                 375                 380                 


Pro Lys Lys Gly Pro Pro Ala Lys Lys Pro Gly Lys His Ser Asp Lys 
385                 390                 395                 400 


Pro Leu Lys Ala Lys Gly Arg Ser Lys Gly Ile Leu Asn Gly Gln Lys 
                405                 410                 415     


Ser Xaa Gly Asn Ser Lys Ser Pro Lys Lys Gly Leu Lys Xaa Pro Lys 
            420                 425                 430         


Xaa Lys Met Lys Gln Met Xaa Leu Leu Asp Met Ala Lys Gly Xaa Gln 
        435                 440                 445             


Lys Met Xaa Arg Ala Pro Arg Asn Ser Gly Gly Xaa Pro Arg Xaa Ser 
    450                 455                 460                 


Ser Lys Pro His Lys His Leu Pro Pro Ala Ala Leu His Leu Ile Ala 
465                 470                 475                 480 


Tyr Tyr Lys Glu Asn Lys Asp Arg Glu Asp Lys Arg Ser Ala Leu Ser 
                485                 490                 495     


Cys Val Ile Ser Lys Xaa Ala Arg Leu Leu Ser Ser Glu Asp Arg Ala 
            500                 505                 510         


Arg Leu Pro Glu Glu Leu Arg Ser Leu Val Gln Lys Arg Tyr Glu Leu 
        515                 520                 525             


Leu Glu His Lys Lys Arg Trp Ala Ser Met Ser Glu Glu Gln Arg Lys 
    530                 535                 540                 


Glu Tyr Leu Lys Lys Lys Arg Glu Glu Leu Lys Lys Lys Leu Lys Glu 
545                 550                 555                 560 


Lys Ala Lys Glu Arg Arg Glu Lys Glu Met Leu Glu Arg Leu Glu Lys 
                565                 570                 575     


Gln Lys Arg Tyr Glu Asp Gln Glu Leu Xaa Gly Lys Asn Leu Pro Ala 
            580                 585                 590         


Phe Arg Leu Val Asp Xaa Pro Glu Gly Leu Pro Asn Xaa Leu Phe Gly 
        595                 600                 605             


Asp Val Ala Met Val Val Glu Phe Leu Ser Cys Tyr Ser Gly Leu Leu 
    610                 615                 620                 


Leu Pro Asp Ala Gln Tyr Pro Ile Xaa Ala Val Ser Leu Met Glu Ala 
625                 630                 635                 640 


Leu Ser Ala Asp Lys Gly Gly Phe Leu Tyr Leu Asn Arg Val Leu Val 
                645                 650                 655     


Ile Leu Leu Gln Xaa Leu Leu Gln Asp Glu Ile Ala Glu Asp Tyr Gly 
            660                 665                 670         


Glu Leu Gly Met Lys Leu Ser Glu Ile Pro Leu Xaa Leu His Ser Val 
        675                 680                 685             


Ser Glu Leu Val Arg Leu Cys Leu Arg Arg Ser Asp Val Gln Glu Glu 
    690                 695                 700                 


Ser Glu Gly Ser Asp Xaa Asp Asp Asn Lys Asp Ser Ala Ala Phe Glu 
705                 710                 715                 720 


Asp Asn Glu Val Gln Asp Glu Phe Leu Glu Lys Leu Glu Xaa Ser Glu 
                725                 730                 735     


Phe Phe Glu Leu Xaa Ser Glu Glu Lys Leu Gln Ile Leu Xaa Ala Leu 
            740                 745                 750         


Cys His Arg Ile Leu Met Xaa Tyr Ser Val Gln Asp His Met Glu Xaa 
        755                 760                 765             


Arg Gln Gln Met Ser Ala Glu Leu Trp Lys Glu Arg Leu Ala Val Leu 
    770                 775                 780                 


Lys Glu Glu Asn Asp Lys Lys Arg Ala Glu Lys Gln Lys Arg Lys Glu 
785                 790                 795                 800 


Met Glu Ala Lys Asn Lys Glu Asn Gly Lys Val Glu Asn Gly Leu Gly 
                805                 810                 815     


Lys Xaa Asp Arg Lys Lys Glu Ile Val Lys Phe Glu Pro Gln Val Asp 
            820                 825                 830         


Xaa Glu Ala Glu Asp Met Ile Ser Ala Val Lys Ser Arg Arg Leu Leu 
        835                 840                 845             


Ala Ile Gln Ala Lys Lys Glu Arg Glu Ile Gln Glu Arg Glu Met Lys 
    850                 855                 860                 


Val Lys Leu Glu Arg Gln Ala Glu Glu Glu Arg Ile Arg Lys His Lys 
865                 870                 875                 880 


Ala Ala Ala Glu Lys Ala Phe Gln Glu Gly Ile Ala Lys Ala Lys Leu 
                885                 890                 895     


Val Met Arg Arg Xaa Pro Ile Gly Xaa Asp Arg Asn His Asn Arg Tyr 
            900                 905                 910         


Trp Leu Phe Ser Asp Glu Val Pro Gly Leu Phe Ile Glu Lys Gly Trp 
        915                 920                 925             


Val His Asp Ser Ile Asp Tyr Arg Phe Asn His His Cys Lys Asp His 
    930                 935                 940                 


Xaa Val Ser Gly Asp Glu Asp Tyr Cys Pro Arg Ser Lys Lys Ala Asn 
945                 950                 955                 960 


Leu Gly Lys Asn Ala Ser Met Asn Xaa Gln His Gly Xaa Ala Xaa Glu 
                965                 970                 975     


Val Ala Val Glu Xaa Xaa Xaa Pro Lys Gln Gly Gln Asn Leu Trp Phe 
            980                 985                 990         


Leu Cys Asp Ser Gln Lys Glu Leu  Asp Glu Leu Leu Asn  Cys Leu His 
        995                 1000                 1005             


Pro Gln  Gly Ile Arg Glu Ser  Gln Leu Lys Glu Arg  Leu Glu Lys 
    1010                 1015                 1020             


Arg Tyr  Gln Asp Ile Ile His  Ser Ile His Leu Ala  Arg Lys Pro 
    1025                 1030                 1035             


Asn Leu  Gly Leu Lys Ser Cys  Asp Gly Asn Gln Glu  Leu Leu Asn 
    1040                 1045                 1050             


Phe Leu  Arg Ser Asp Leu Ile  Glu Val Ala Xaa Arg  Leu Gln Lys 
    1055                 1060                 1065             


Gly Gly  Leu Gly Tyr Val Glu  Glu Xaa Ser Glu Phe  Glu Ala Arg 
    1070                 1075                 1080             


Val Ile  Ser Leu Glu Lys Leu  Lys Asp Phe Gly Glu  Cys Val Ile 
    1085                 1090                 1095             


Ala Leu  Gln Ala Ser Val Ile  Lys Lys Phe Leu Gln  Gly Phe Met 
    1100                 1105                 1110             


Ala Pro  Lys Gln Lys Arg Arg  Lys Leu Gln Ser Glu  Asp Ser Ala 
    1115                 1120                 1125             


Lys Xaa  Glu Glu Val Asp Glu  Glu Lys Lys Met Val  Glu Glu Ala 
    1130                 1135                 1140             


Lys Val  Ala Ser Ala Leu Glu  Lys Trp Lys Xaa Ala  Ile Arg Glu 
    1145                 1150                 1155             


Ala Gln  Xaa Phe Ser Arg Met  His Val Leu Leu Gly  Met Leu Asp 
    1160                 1165                 1170             


Ala Cys  Ile Lys Trp Asp Met  Ser Ala Glu Asn Ala  Arg Cys Lys 
    1175                 1180                 1185             


Val Cys  Arg Lys Lys Gly Glu  Asp Asp Lys Leu Ile  Leu Cys Asp 
    1190                 1195                 1200             


Glu Cys  Asn Lys Ala Phe His  Leu Phe Cys Leu Arg  Pro Ala Leu 
    1205                 1210                 1215             


Tyr Glu  Val Pro Asp Gly Glu  Trp Gln Cys Pro Ala  Cys Gln Pro 
    1220                 1225                 1230             


Ala Xaa  Ala Arg Arg Asn Ser  Arg Gly Arg Asn Tyr  Xaa Glu Glu 
    1235                 1240                 1245             


Ser Ala  Ser Glu Asp Ser Glu  Asp Asp Glu Ser Asp  Glu Glu Glu 
    1250                 1255                 1260             


Glu Glu  Glu Glu Glu Glu Glu  Glu Glu Glu Asp Tyr  Glu Val Ala 
    1265                 1270                 1275             


Gly Leu  Arg Leu Arg Pro Arg  Lys Xaa Ile Arg Gly  Lys His Ser 
    1280                 1285                 1290             


Val Ile  Pro Pro Ala Ala Arg  Ser Gly Arg Arg Pro  Gly Lys Lys 
    1295                 1300                 1305             


Pro His  Ser Xaa Arg Arg Ser  Gln Pro Lys Ala Pro  Pro Val Asp 
    1310                 1315                 1320             


Asp Ala  Glu Val Asp Glu Leu  Val Leu Gln Xaa Lys  Arg Ser Ser 
    1325                 1330                 1335             


Arg Arg  Gln Ser Leu Glu Leu  Gln Lys Cys Glu Glu  Ile Leu His 
    1340                 1345                 1350             


Lys Ile  Val Lys Tyr Arg Phe  Ser Trp Pro Phe Arg  Glu Pro Val 
    1355                 1360                 1365             


Xaa Arg  Asp Glu Ala Glu Asp  Tyr Tyr Asp Val Ile  Xaa His Pro 
    1370                 1375                 1380             


Met Asp  Phe Gln Xaa Val Gln  Asn Lys Cys Ser Cys  Gly Ser Tyr 
    1385                 1390                 1395             


Arg Ser  Val Gln Glu Phe Leu  Xaa Asp Met Lys Gln  Val Phe Xaa 
    1400                 1405                 1410             


Asn Ala  Glu Val Tyr Asn Cys  Arg Gly Ser His Val  Leu Ser Cys 
    1415                 1420                 1425             


Met Val  Lys Xaa Glu Gln Cys  Leu Val Ala Leu Leu  His Lys His 
    1430                 1435                 1440             


Leu Pro  Gly His Pro Tyr Val  Arg Arg Lys Arg Lys  Lys Phe Pro 
    1445                 1450                 1455             


Asp Arg  Leu Ala Glu Asp Glu  Gly Asp Ser Glu Pro  Glu Ala Val 
    1460                 1465                 1470             


Gly Gln  Ser Arg Gly Arg Arg  Gln Lys Lys 
    1475                 1480             


<210> 3958
<211> 116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<400> 3958
Met Glu Ala Asn Asp His Phe Asn Phe Xaa Gly Leu Pro Pro Ala Pro 
1               5                   10                  15      


Ala Ala Ser Gly Leu Lys Pro Ser Pro Ser Ser Gly Glu Gly Leu Tyr 
            20                  25                  30          


Xaa Asn Gly Ser Pro Met Asn Phe Pro Gln Gln Gly Lys Ser Leu Asn 
        35                  40                  45              


Gly Asp Val Asn Val Asn Gly Leu Ser Xaa Val Ser His Xaa Xaa Xaa 
    50                  55                  60                  


Ser Gly Ile Leu Asn Ser Ala Pro His Ser Ser Ser Xaa Ser His Leu 
65                  70                  75                  80  


His His Pro Ser Val Ala Tyr Asp Cys Leu Trp Asn Tyr Ser Gln Tyr 
                85                  90                  95      


Pro Ser Ala Asn Pro Gly Ser Asn Leu Lys Asp Pro Pro Leu Leu Ser 
            100                 105                 110         


Gln Phe Ser Gly 
        115     


<210> 3959
<211> 132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<400> 3959
Met Glu Ala Asn Asp His Phe Asn Phe Xaa Gly Leu Pro Pro Ala Pro 
1               5                   10                  15      


Ala Ala Ser Gly Leu Lys Pro Ser Pro Ser Ser Gly Glu Gly Leu Tyr 
            20                  25                  30          


Xaa Asn Gly Ser Pro Met Asn Phe Pro Gln Gln Gly Lys Ser Leu Asn 
        35                  40                  45              


Gly Asp Val Asn Val Asn Gly Leu Ser Xaa Val Ser His Xaa Xaa Xaa 
    50                  55                  60                  


Ser Gly Ile Leu Asn Ser Ala Pro His Ser Ser Ser Xaa Ser His Leu 
65                  70                  75                  80  


His His Pro Ser Val Ala Tyr Asp Cys Leu Trp Asn Tyr Ser Gln Tyr 
                85                  90                  95      


Pro Ser Ala Asn Pro Gly Ser Asn Leu Lys Asp Pro Pro Leu Leu Ser 
            100                 105                 110         


Gln Phe Ser Gly Gly Gln Tyr Pro Leu Asn Gly Ile Leu Gly Gly Ser 
        115                 120                 125             


Arg Gln Pro Ser 
    130         


<210> 3960
<211> 1903
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1193)..(1193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1287)..(1287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1346)..(1346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1375)..(1375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1397)..(1397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1422)..(1422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1425)..(1425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1508)..(1508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1511)..(1511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1537)..(1537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1544)..(1544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1562)..(1562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1577)..(1578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1619)..(1619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1627)..(1629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1636)..(1636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1645)..(1645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1676)..(1676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1719)..(1719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1731)..(1731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1798)..(1798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1840)..(1840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1851)..(1851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1869)..(1869)
<223> Selenocysteine

<400> 3960
Met Glu Ala Asn Asp His Phe Asn Phe Xaa Gly Leu Pro Pro Ala Pro 
1               5                   10                  15      


Ala Ala Ser Gly Leu Lys Pro Ser Pro Ser Ser Gly Glu Gly Leu Tyr 
            20                  25                  30          


Xaa Asn Gly Ser Pro Met Asn Phe Pro Gln Gln Gly Lys Ser Leu Asn 
        35                  40                  45              


Gly Asp Val Asn Val Asn Gly Leu Ser Xaa Val Ser His Xaa Xaa Xaa 
    50                  55                  60                  


Ser Gly Ile Leu Asn Ser Ala Pro His Ser Ser Ser Xaa Ser His Leu 
65                  70                  75                  80  


His His Pro Ser Val Ala Tyr Asp Cys Leu Trp Asn Tyr Ser Gln Tyr 
                85                  90                  95      


Pro Ser Ala Asn Pro Gly Ser Asn Leu Lys Asp Pro Pro Leu Leu Ser 
            100                 105                 110         


Gln Phe Ser Gly Gly Gln Tyr Pro Leu Asn Gly Ile Leu Gly Gly Ser 
        115                 120                 125             


Arg Gln Pro Ser Ser Pro Ser His Asn Xaa Asn Leu Arg Ala Gly Ser 
    130                 135                 140                 


Gln Glu Phe Trp Ala Asn Gly Xaa Gln Ser Pro Met Gly Leu Asn Phe 
145                 150                 155                 160 


Asp Ser Gln Glu Leu Tyr Asp Ser Phe Pro Asp Gln Asn Phe Glu Val 
                165                 170                 175     


Met Pro Asn Gly Pro Pro Ser Phe Phe Xaa Ser Pro Gln Xaa Ser Pro 
            180                 185                 190         


Met Leu Gly Ser Ser Ile Gln Xaa Phe Ala Pro Ser Gln Glu Val Gly 
        195                 200                 205             


Ser Gly Ile His Pro Asp Glu Ala Ala Glu Lys Glu Met Xaa Ser Val 
    210                 215                 220                 


Val Ala Glu Asn Gly Xaa Gly Leu Val Gly Ser Leu Glu Leu Glu Glu 
225                 230                 235                 240 


Glu Gln Pro Glu Leu Lys Met Cys Gly Tyr Asn Gly Ser Val Pro Ser 
                245                 250                 255     


Val Glu Ser Leu His Gln Glu Val Ser Val Leu Val Pro Asp Pro Xaa 
            260                 265                 270         


Val Ser Cys Leu Asp Asp Pro Ser His Leu Pro Asp Gln Leu Glu Asp 
        275                 280                 285             


Xaa Pro Ile Leu Ser Glu Asp Ser Leu Glu Pro Phe Asn Ser Leu Ala 
    290                 295                 300                 


Pro Glu Pro Val Ser Gly Gly Leu Tyr Gly Ile Asp Asp Xaa Glu Leu 
305                 310                 315                 320 


Met Gly Ala Glu Asp Lys Leu Pro Leu Glu Asp Ser Pro Val Ile Ser 
                325                 330                 335     


Ala Leu Asp Cys Pro Ser Leu Asn Asn Ala Xaa Ala Phe Ser Leu Leu 
            340                 345                 350         


Ala Asp Asp Ser Gln Xaa Ser Xaa Ser Ile Phe Ala Ser Pro Xaa Ser 
        355                 360                 365             


Pro Pro Val Leu Gly Glu Ser Val Leu Gln Asp Asn Ser Phe Asp Leu 
    370                 375                 380                 


Asn Asn Gly Ser Asp Ala Glu Gln Glu Glu Met Glu Xaa Gln Ser Ser 
385                 390                 395                 400 


Asp Phe Pro Pro Ser Leu Xaa Gln Pro Ala Pro Asp Gln Ser Ser Xaa 
                405                 410                 415     


Ile Gln Leu His Pro Ala Xaa Ser Pro Ala Val Ser Pro Xaa Xaa Ser 
            420                 425                 430         


Pro Ala Val Ser Leu Val Val Ser Pro Ala Ala Ser Pro Glu Ile Ser 
        435                 440                 445             


Pro Glu Val Cys Pro Ala Ala Ser Xaa Val Val Ser Pro Ala Val Phe 
    450                 455                 460                 


Ser Val Val Ser Pro Ala Ser Ser Ala Val Leu Pro Ala Val Ser Leu 
465                 470                 475                 480 


Glu Val Pro Leu Xaa Ala Ser Val Xaa Ser Pro Lys Ala Ser Pro Val 
                485                 490                 495     


Xaa Ser Pro Ala Ala Ala Phe Pro Xaa Ala Ser Pro Ala Asn Lys Asp 
            500                 505                 510         


Val Ser Ser Phe Leu Glu Xaa Xaa Ala Asp Val Glu Glu Ile Xaa Gly 
        515                 520                 525             


Glu Gly Leu Xaa Ala Ser Gly Ser Gly Asp Val Met Arg Arg Arg Ile 
    530                 535                 540                 


Ala Xaa Pro Glu Glu Val Arg Leu Pro Leu Gln His Gly Trp Arg Arg 
545                 550                 555                 560 


Glu Val Arg Ile Lys Lys Gly Ser His Arg Trp Gln Gly Glu Xaa Trp 
                565                 570                 575     


Tyr Tyr Gly Pro Cys Gly Lys Arg Met Lys Gln Phe Pro Glu Val Ile 
            580                 585                 590         


Lys Tyr Leu Ser Arg Asn Val Val His Ser Val Arg Arg Glu His Phe 
        595                 600                 605             


Ser Phe Ser Pro Arg Met Pro Val Gly Asp Phe Phe Glu Glu Arg Asp 
    610                 615                 620                 


Xaa Pro Glu Gly Leu Gln Trp Val Gln Leu Ser Ala Glu Glu Ile Pro 
625                 630                 635                 640 


Ser Arg Ile Gln Ala Ile Xaa Gly Lys Arg Gly Arg Pro Arg Asn Xaa 
                645                 650                 655     


Glu Lys Ala Lys Xaa Lys Glu Val Pro Lys Val Lys Arg Gly Arg Gly 
            660                 665                 670         


Arg Pro Pro Lys Val Lys Ile Xaa Glu Leu Leu Asn Lys Xaa Asp Asn 
        675                 680                 685             


Arg Pro Leu Lys Lys Leu Glu Ala Gln Glu Xaa Leu Asn Glu Glu Asp 
    690                 695                 700                 


Lys Ala Lys Ile Ala Lys Ser Lys Lys Lys Met Arg Gln Lys Val Gln 
705                 710                 715                 720 


Arg Gly Glu Cys Gln Xaa Xaa Ile Gln Gly Gln Ala Arg Asn Lys Arg 
                725                 730                 735     


Lys Gln Glu Xaa Lys Ser Leu Lys Gln Lys Glu Ala Lys Lys Lys Ser 
            740                 745                 750         


Lys Ala Glu Lys Glu Lys Gly Lys Xaa Lys Gln Glu Lys Leu Lys Glu 
        755                 760                 765             


Lys Val Lys Arg Glu Lys Lys Glu Lys Val Lys Met Lys Glu Lys Glu 
    770                 775                 780                 


Glu Val Xaa Lys Ala Lys Pro Ala Cys Lys Ala Asp Lys Xaa Leu Ala 
785                 790                 795                 800 


Xaa Gln Arg Arg Leu Glu Glu Arg Gln Arg Gln Gln Met Ile Leu Glu 
                805                 810                 815     


Glu Met Lys Lys Pro Xaa Glu Asp Met Cys Leu Xaa Asp His Gln Pro 
            820                 825                 830         


Leu Pro Asp Phe Ser Arg Val Pro Gly Leu Xaa Leu Pro Ser Gly Ala 
        835                 840                 845             


Phe Ser Asp Cys Leu Xaa Ile Val Glu Phe Leu His Ser Phe Gly Lys 
    850                 855                 860                 


Val Leu Gly Phe Asp Pro Ala Lys Asp Val Pro Ser Leu Gly Val Leu 
865                 870                 875                 880 


Gln Glu Gly Leu Leu Cys Gln Gly Asp Ser Leu Gly Glu Val Gln Asp 
                885                 890                 895     


Leu Leu Val Arg Leu Leu Lys Ala Ala Leu His Asp Pro Gly Phe Pro 
            900                 905                 910         


Ser Tyr Cys Gln Ser Leu Lys Ile Leu Gly Glu Lys Val Ser Glu Ile 
        915                 920                 925             


Pro Leu Xaa Arg Asp Asn Val Ser Glu Ile Leu Arg Cys Phe Leu Met 
    930                 935                 940                 


Ala Tyr Gly Val Glu Pro Ala Leu Cys Asp Arg Leu Arg Xaa Gln Pro 
945                 950                 955                 960 


Phe Gln Ala Gln Pro Pro Gln Gln Lys Ala Ala Val Leu Ala Phe Leu 
                965                 970                 975     


Val His Glu Leu Asn Gly Ser Xaa Leu Ile Ile Asn Glu Ile Asp Lys 
            980                 985                 990         


Xaa Leu Glu Ser Met Ser Ser Tyr  Arg Lys Asn Lys Trp  Ile Val Glu 
        995                 1000                 1005             


Gly Arg  Leu Arg Arg Leu Lys  Xaa Val Leu Ala Lys  Arg Xaa Gly 
    1010                 1015                 1020             


Arg Ser  Glu Val Glu Met Glu  Gly Pro Glu Glu Cys  Leu Gly Arg 
    1025                 1030                 1035             


Arg Arg  Ser Ser Arg Ile Met  Glu Glu Xaa Ser Gly  Met Glu Glu 
    1040                 1045                 1050             


Glu Glu  Glu Glu Glu Ser Ile  Ala Ala Val Pro Gly  Arg Arg Gly 
    1055                 1060                 1065             


Arg Arg  Asp Gly Glu Val Asp  Ala Xaa Ala Ser Ser  Ile Pro Glu 
    1070                 1075                 1080             


Leu Glu  Arg Gln Ile Glu Lys  Leu Ser Lys Arg Gln  Leu Phe Phe 
    1085                 1090                 1095             


Arg Lys  Lys Leu Leu His Ser  Ser Gln Met Leu Arg  Ala Val Ser 
    1100                 1105                 1110             


Leu Gly  Gln Asp Arg Tyr Arg  Arg Arg Tyr Trp Val  Leu Pro Tyr 
    1115                 1120                 1125             


Leu Ala  Gly Ile Phe Val Glu  Gly Xaa Glu Gly Asn  Leu Val Pro 
    1130                 1135                 1140             


Glu Glu  Val Ile Lys Lys Glu  Xaa Asp Ser Leu Lys  Val Ala Ala 
    1145                 1150                 1155             


His Ala  Ser Leu Asn Pro Ala  Leu Phe Ser Met Lys  Met Glu Leu 
    1160                 1165                 1170             


Ala Gly  Ser Asn Xaa Xaa Ala  Ser Ser Pro Ala Arg  Ala Arg Gly 
    1175                 1180                 1185             


Arg Pro  Arg Lys Xaa Lys Pro  Gly Ser Met Gln Pro  Arg His Leu 
    1190                 1195                 1200             


Lys Ser  Pro Val Arg Gly Gln  Asp Ser Glu Gln Pro  Gln Ala Gln 
    1205                 1210                 1215             


Leu Gln  Pro Glu Ala Gln Leu  His Ala Pro Ala Gln  Pro Gln Pro 
    1220                 1225                 1230             


Gln Leu  Gln Leu Gln Leu Gln  Ser His Lys Gly Phe  Leu Glu Gln 
    1235                 1240                 1245             


Glu Gly  Ser Pro Leu Ser Leu  Gly Gln Ser Gln His  Asp Leu Ser 
    1250                 1255                 1260             


Gln Ser  Ala Phe Leu Ser Trp  Leu Ser Gln Xaa Gln  Ser His Ser 
    1265                 1270                 1275             


Ser Leu  Leu Ser Ser Ser Val  Leu Xaa Pro Asp Ser  Ser Pro Gly 
    1280                 1285                 1290             


Lys Leu  Asp Pro Ala Pro Ser  Gln Pro Pro Glu Glu  Pro Glu Pro 
    1295                 1300                 1305             


Asp Glu  Ala Glu Ser Ser Pro  Asp Pro Gln Ala Leu  Trp Phe Asn 
    1310                 1315                 1320             


Ile Ser  Ala Gln Met Pro Cys  Asn Ala Ala Pro Xaa  Pro Pro Pro 
    1325                 1330                 1335             


Ala Val  Ser Glu Asp Gln Pro  Xaa Pro Ser Pro Gln  Gln Leu Ala 
    1340                 1345                 1350             


Ser Ser  Lys Pro Met Asn Arg  Pro Ser Ala Ala Asn  Pro Cys Ser 
    1355                 1360                 1365             


Pro Val  Gln Phe Ser Ser Xaa  Pro Leu Ala Gly Leu  Ala Pro Lys 
    1370                 1375                 1380             


Arg Arg  Ala Gly Asp Pro Gly  Glu Met Pro Gln Ser  Pro Xaa Gly 
    1385                 1390                 1395             


Leu Gly  Gln Pro Lys Arg Arg  Gly Arg Pro Pro Ser  Lys Phe Phe 
    1400                 1405                 1410             


Lys Gln  Met Glu Gln Arg Tyr  Leu Xaa Gln Leu Xaa  Ala Gln Pro 
    1415                 1420                 1425             


Val Pro  Pro Glu Met Cys Ser  Gly Trp Trp Trp Ile  Arg Asp Pro 
    1430                 1435                 1440             


Glu Met  Leu Asp Ala Met Leu  Lys Ala Leu His Pro  Arg Gly Ile 
    1445                 1450                 1455             


Arg Glu  Lys Ala Leu His Lys  His Leu Asn Lys His  Arg Asp Phe 
    1460                 1465                 1470             


Leu Gln  Glu Val Cys Leu Arg  Pro Ser Ala Asp Pro  Ile Phe Glu 
    1475                 1480                 1485             


Pro Arg  Gln Leu Pro Ala Phe  Gln Glu Gly Ile Met  Ser Trp Ser 
    1490                 1495                 1500             


Pro Lys  Glu Lys Xaa Tyr Glu  Xaa Asp Leu Ala Val  Leu Gln Trp 
    1505                 1510                 1515             


Val Glu  Glu Leu Glu Gln Arg  Val Ile Met Ser Asp  Leu Gln Ile 
    1520                 1525                 1530             


Arg Gly  Trp Xaa Cys Pro Ser  Pro Asp Ser Xaa Arg  Glu Asp Leu 
    1535                 1540                 1545             


Ala Tyr  Cys Glu His Leu Ser  Asp Ser Gln Glu Asp  Ile Xaa Trp 
    1550                 1555                 1560             


Arg Gly  Arg Gly Arg Glu Gly  Leu Ala Pro Gln Arg  Lys Xaa Xaa 
    1565                 1570                 1575             


Asn Pro  Leu Asp Leu Ala Val  Met Arg Leu Ala Ala  Leu Glu Gln 
    1580                 1585                 1590             


Asn Val  Glu Arg Arg Tyr Leu  Arg Glu Pro Leu Trp  Pro Xaa His 
    1595                 1600                 1605             


Glu Val  Val Leu Glu Lys Ala  Leu Leu Ser Xaa Pro  Asn Gly Ala 
    1610                 1615                 1620             


Pro Glu  Gly Xaa Xaa Xaa Glu  Ile Ser Tyr Glu Ile  Xaa Pro Arg 
    1625                 1630                 1635             


Ile Arg  Val Trp Arg Gln Xaa  Leu Glu Arg Cys Arg  Ser Ala Ala 
    1640                 1645                 1650             


Gln Val  Cys Leu Cys Leu Gly  Gln Leu Glu Arg Ser  Ile Ala Trp 
    1655                 1660                 1665             


Glu Lys  Ser Val Asn Lys Val  Xaa Cys Leu Val Cys  Arg Lys Gly 
    1670                 1675                 1680             


Asp Asn  Asp Glu Phe Leu Leu  Leu Cys Asp Gly Cys  Asp Arg Gly 
    1685                 1690                 1695             


Cys His  Ile Tyr Cys His Arg  Pro Lys Met Glu Ala  Val Pro Glu 
    1700                 1705                 1710             


Gly Asp  Trp Phe Cys Xaa Val  Cys Leu Ala Gln Gln  Val Glu Gly 
    1715                 1720                 1725             


Glu Phe  Xaa Gln Lys Pro Gly  Phe Pro Lys Arg Gly  Gln Lys Arg 
    1730                 1735                 1740             


Lys Ser  Gly Tyr Ser Leu Asn  Phe Ser Glu Gly Asp  Gly Arg Arg 
    1745                 1750                 1755             


Arg Arg  Val Leu Leu Arg Gly  Arg Glu Ser Pro Ala  Ala Gly Pro 
    1760                 1765                 1770             


Arg Tyr  Ser Glu Glu Gly Leu  Ser Pro Ser Lys Arg  Arg Arg Leu 
    1775                 1780                 1785             


Ser Met  Arg Asn His His Ser  Asp Leu Xaa Phe Cys  Glu Ile Ile 
    1790                 1795                 1800             


Leu Met  Glu Met Glu Ser His  Asp Ala Ala Trp Pro  Phe Leu Glu 
    1805                 1810                 1815             


Pro Val  Asn Pro Arg Leu Val  Ser Gly Tyr Arg Arg  Ile Ile Lys 
    1820                 1825                 1830             


Asn Pro  Met Asp Phe Ser Xaa  Met Arg Glu Arg Leu  Leu Arg Gly 
    1835                 1840                 1845             


Gly Tyr  Xaa Ser Ser Glu Glu  Phe Ala Ala Asp Ala  Leu Leu Val 
    1850                 1855                 1860             


Phe Asp  Asn Cys Gln Xaa Phe  Asn Glu Asp Asp Ser  Glu Val Gly 
    1865                 1870                 1875             


Lys Ala  Gly His Ile Met Arg  Arg Phe Phe Glu Ser  Arg Trp Glu 
    1880                 1885                 1890             


Glu Phe  Tyr Gln Gly Lys Gln  Ala Asn Leu 
    1895                 1900             


<210> 3961
<211> 1875
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1123)..(1123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1246)..(1246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1347)..(1347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1369)..(1369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1394)..(1394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1397)..(1397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1480)..(1480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1509)..(1509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1516)..(1516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1534)..(1534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1549)..(1550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1579)..(1579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1591)..(1591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1599)..(1601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1608)..(1608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1617)..(1617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1648)..(1648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1691)..(1691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1703)..(1703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1770)..(1770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1812)..(1812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1823)..(1823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1841)..(1841)
<223> Selenocysteine

<400> 3961
Met Glu Met Glu Ala Asn Asp His Phe Asn Phe Xaa Gly Leu Pro Pro 
1               5                   10                  15      


Ala Pro Ala Ala Ser Gly Leu Lys Pro Ser Pro Ser Ser Gly Glu Gly 
            20                  25                  30          


Leu Tyr Xaa Asn Gly Ser Pro Met Asn Phe Pro Gln Gln Gly Lys Ser 
        35                  40                  45              


Leu Asn Gly Asp Val Asn Val Asn Gly Leu Ser Xaa Val Ser His Xaa 
    50                  55                  60                  


Xaa Xaa Ser Gly Ile Leu Asn Ser Ala Pro His Ser Ser Ser Xaa Ser 
65                  70                  75                  80  


His Leu His His Pro Ser Val Ala Tyr Asp Cys Leu Trp Asn Tyr Ser 
                85                  90                  95      


Gln Tyr Pro Ser Ala Asn Pro Gly Ser Asn Leu Lys Asp Pro Pro Leu 
            100                 105                 110         


Leu Ser Gln Phe Ser Gly Gly Gln Tyr Pro Leu Asn Gly Ile Leu Gly 
        115                 120                 125             


Gly Ser Arg Gln Pro Ser Ser Pro Ser His Asn Xaa Asn Leu Arg Ala 
    130                 135                 140                 


Gly Ser Gln Glu Phe Trp Ala Asn Gly Xaa Gln Ser Pro Met Gly Leu 
145                 150                 155                 160 


Asn Phe Asp Ser Gln Glu Leu Tyr Asp Ser Phe Pro Asp Gln Asn Phe 
                165                 170                 175     


Glu Glu Val Gly Ser Gly Ile His Pro Asp Glu Ala Ala Glu Lys Glu 
            180                 185                 190         


Met Xaa Ser Val Val Ala Glu Asn Gly Xaa Gly Leu Val Gly Ser Leu 
        195                 200                 205             


Glu Leu Glu Glu Glu Gln Pro Glu Leu Lys Met Cys Gly Tyr Asn Gly 
    210                 215                 220                 


Ser Val Pro Ser Val Glu Ser Leu His Gln Glu Val Ser Val Leu Val 
225                 230                 235                 240 


Pro Asp Pro Xaa Val Ser Cys Leu Asp Asp Pro Ser His Leu Pro Asp 
                245                 250                 255     


Gln Leu Glu Asp Xaa Pro Ile Leu Ser Glu Asp Ser Leu Glu Pro Phe 
            260                 265                 270         


Asn Ser Leu Ala Pro Glu Pro Val Ser Gly Gly Leu Tyr Gly Ile Asp 
        275                 280                 285             


Asp Xaa Glu Leu Met Gly Ala Glu Asp Lys Leu Pro Leu Glu Asp Ser 
    290                 295                 300                 


Pro Val Ile Ser Ala Leu Asp Cys Pro Ser Leu Asn Asn Ala Xaa Ala 
305                 310                 315                 320 


Phe Ser Leu Leu Ala Asp Asp Ser Gln Xaa Ser Xaa Ser Ile Phe Ala 
                325                 330                 335     


Ser Pro Xaa Ser Pro Pro Val Leu Gly Glu Ser Val Leu Gln Asp Asn 
            340                 345                 350         


Ser Phe Asp Leu Asn Asn Gly Ser Asp Ala Glu Gln Glu Glu Met Glu 
        355                 360                 365             


Xaa Gln Ser Ser Asp Phe Pro Pro Ser Leu Xaa Gln Pro Ala Pro Asp 
    370                 375                 380                 


Gln Ser Ser Xaa Ile Gln Leu His Pro Ala Xaa Ser Pro Ala Val Ser 
385                 390                 395                 400 


Pro Xaa Xaa Ser Pro Ala Val Ser Leu Val Val Ser Pro Ala Ala Ser 
                405                 410                 415     


Pro Glu Ile Ser Pro Glu Val Cys Pro Ala Ala Ser Xaa Val Val Ser 
            420                 425                 430         


Pro Ala Val Phe Ser Val Val Ser Pro Ala Ser Ser Ala Val Leu Pro 
        435                 440                 445             


Ala Val Ser Leu Glu Val Pro Leu Xaa Ala Ser Val Xaa Ser Pro Lys 
    450                 455                 460                 


Ala Ser Pro Val Xaa Ser Pro Ala Ala Ala Phe Pro Xaa Ala Ser Pro 
465                 470                 475                 480 


Ala Asn Lys Asp Val Ser Ser Phe Leu Glu Xaa Xaa Ala Asp Val Glu 
                485                 490                 495     


Glu Ile Xaa Gly Glu Gly Leu Xaa Ala Ser Gly Ser Gly Asp Val Met 
            500                 505                 510         


Arg Arg Arg Ile Ala Xaa Pro Glu Glu Val Arg Leu Pro Leu Gln His 
        515                 520                 525             


Gly Trp Arg Arg Glu Val Arg Ile Lys Lys Gly Ser His Arg Trp Gln 
    530                 535                 540                 


Gly Glu Xaa Trp Tyr Tyr Gly Pro Cys Gly Lys Arg Met Lys Gln Phe 
545                 550                 555                 560 


Pro Glu Val Ile Lys Tyr Leu Ser Arg Asn Val Val His Ser Val Arg 
                565                 570                 575     


Arg Glu His Phe Ser Phe Ser Pro Arg Met Pro Val Gly Asp Phe Phe 
            580                 585                 590         


Glu Glu Arg Asp Xaa Pro Glu Gly Leu Gln Trp Val Gln Leu Ser Ala 
        595                 600                 605             


Glu Glu Ile Pro Ser Arg Ile Gln Ala Ile Xaa Gly Lys Arg Gly Arg 
    610                 615                 620                 


Pro Arg Asn Xaa Glu Lys Ala Lys Xaa Lys Glu Val Pro Lys Val Lys 
625                 630                 635                 640 


Arg Gly Arg Gly Arg Pro Pro Lys Val Lys Ile Xaa Glu Leu Leu Asn 
                645                 650                 655     


Lys Xaa Asp Asn Arg Pro Leu Lys Lys Leu Glu Ala Gln Glu Xaa Leu 
            660                 665                 670         


Asn Glu Glu Asp Lys Ala Lys Ile Ala Lys Ser Lys Lys Lys Met Arg 
        675                 680                 685             


Gln Lys Val Gln Arg Gly Glu Cys Gln Xaa Xaa Ile Gln Gly Gln Ala 
    690                 695                 700                 


Arg Asn Lys Arg Lys Gln Glu Xaa Lys Ser Leu Lys Gln Lys Glu Ala 
705                 710                 715                 720 


Lys Lys Lys Ser Lys Ala Glu Lys Glu Lys Gly Lys Xaa Lys Gln Glu 
                725                 730                 735     


Lys Leu Lys Glu Lys Val Lys Arg Glu Lys Lys Glu Lys Val Lys Met 
            740                 745                 750         


Lys Glu Lys Glu Glu Val Xaa Lys Ala Lys Pro Ala Cys Lys Ala Asp 
        755                 760                 765             


Lys Xaa Leu Ala Xaa Gln Arg Arg Leu Glu Glu Arg Gln Arg Gln Gln 
    770                 775                 780                 


Met Ile Leu Glu Glu Met Lys Lys Pro Xaa Glu Asp Met Cys Leu Xaa 
785                 790                 795                 800 


Asp His Gln Pro Leu Pro Asp Phe Ser Arg Val Pro Gly Leu Xaa Leu 
                805                 810                 815     


Pro Ser Gly Ala Phe Ser Asp Cys Leu Xaa Ile Val Glu Phe Leu His 
            820                 825                 830         


Ser Phe Gly Lys Val Leu Gly Phe Asp Pro Ala Lys Asp Val Pro Ser 
        835                 840                 845             


Leu Gly Val Leu Gln Glu Gly Leu Leu Cys Gln Gly Asp Ser Leu Gly 
    850                 855                 860                 


Glu Val Gln Asp Leu Leu Val Arg Leu Leu Lys Ala Ala Leu His Asp 
865                 870                 875                 880 


Pro Gly Phe Pro Ser Tyr Cys Gln Ser Leu Lys Ile Leu Gly Glu Lys 
                885                 890                 895     


Val Ser Glu Ile Pro Leu Xaa Arg Asp Asn Val Ser Glu Ile Leu Arg 
            900                 905                 910         


Cys Phe Leu Met Ala Tyr Gly Val Glu Pro Ala Leu Cys Asp Arg Leu 
        915                 920                 925             


Arg Xaa Gln Pro Phe Gln Ala Gln Pro Pro Gln Gln Lys Ala Ala Val 
    930                 935                 940                 


Leu Ala Phe Leu Val His Glu Leu Asn Gly Ser Xaa Leu Ile Ile Asn 
945                 950                 955                 960 


Glu Ile Asp Lys Xaa Leu Glu Ser Met Ser Ser Tyr Arg Lys Asn Lys 
                965                 970                 975     


Trp Ile Val Glu Gly Arg Leu Arg Arg Leu Lys Xaa Val Leu Ala Lys 
            980                 985                 990         


Arg Xaa Gly Arg Ser Glu Val Glu  Met Glu Gly Pro Glu  Glu Cys Leu 
        995                 1000                 1005             


Gly Arg  Arg Arg Ser Ser Arg  Ile Met Glu Glu Xaa  Ser Gly Met 
    1010                 1015                 1020             


Glu Glu  Glu Glu Glu Glu Glu  Ser Ile Ala Ala Val  Pro Gly Arg 
    1025                 1030                 1035             


Arg Gly  Arg Arg Asp Gly Glu  Val Asp Ala Xaa Ala  Ser Ser Ile 
    1040                 1045                 1050             


Pro Glu  Leu Glu Arg Gln Ile  Glu Lys Leu Ser Lys  Arg Gln Leu 
    1055                 1060                 1065             


Phe Phe  Arg Lys Lys Leu Leu  His Ser Ser Gln Met  Leu Arg Ala 
    1070                 1075                 1080             


Val Ser  Leu Gly Gln Asp Arg  Tyr Arg Arg Arg Tyr  Trp Val Leu 
    1085                 1090                 1095             


Pro Tyr  Leu Ala Gly Ile Phe  Val Glu Gly Xaa Glu  Gly Asn Leu 
    1100                 1105                 1110             


Val Pro  Glu Glu Val Ile Lys  Lys Glu Xaa Asp Ser  Leu Lys Val 
    1115                 1120                 1125             


Ala Ala  His Ala Ser Leu Asn  Pro Ala Leu Phe Ser  Met Lys Met 
    1130                 1135                 1140             


Glu Leu  Ala Gly Ser Asn Xaa  Xaa Ala Ser Ser Pro  Ala Arg Ala 
    1145                 1150                 1155             


Arg Gly  Arg Pro Arg Lys Xaa  Lys Pro Gly Ser Met  Gln Pro Arg 
    1160                 1165                 1170             


His Leu  Lys Ser Pro Val Arg  Gly Gln Asp Ser Glu  Gln Pro Gln 
    1175                 1180                 1185             


Ala Gln  Leu Gln Pro Glu Ala  Gln Leu His Ala Pro  Ala Gln Pro 
    1190                 1195                 1200             


Gln Pro  Gln Leu Gln Leu Gln  Leu Gln Ser His Lys  Gly Phe Leu 
    1205                 1210                 1215             


Glu Gln  Glu Gly Ser Pro Leu  Ser Leu Gly Gln Ser  Gln His Asp 
    1220                 1225                 1230             


Leu Ser  Gln Ser Ala Phe Leu  Ser Trp Leu Ser Gln  Xaa Gln Ser 
    1235                 1240                 1245             


His Ser  Ser Leu Leu Ser Ser  Ser Val Leu Xaa Pro  Asp Ser Ser 
    1250                 1255                 1260             


Pro Gly  Lys Leu Asp Pro Ala  Pro Ser Gln Pro Pro  Glu Glu Pro 
    1265                 1270                 1275             


Glu Pro  Asp Glu Ala Glu Ser  Ser Pro Asp Pro Gln  Ala Leu Trp 
    1280                 1285                 1290             


Phe Asn  Ile Ser Ala Gln Met  Pro Cys Asn Ala Ala  Pro Xaa Pro 
    1295                 1300                 1305             


Pro Pro  Ala Val Ser Glu Asp  Gln Pro Xaa Pro Ser  Pro Gln Gln 
    1310                 1315                 1320             


Leu Ala  Ser Ser Lys Pro Met  Asn Arg Pro Ser Ala  Ala Asn Pro 
    1325                 1330                 1335             


Cys Ser  Pro Val Gln Phe Ser  Ser Xaa Pro Leu Ala  Gly Leu Ala 
    1340                 1345                 1350             


Pro Lys  Arg Arg Ala Gly Asp  Pro Gly Glu Met Pro  Gln Ser Pro 
    1355                 1360                 1365             


Xaa Gly  Leu Gly Gln Pro Lys  Arg Arg Gly Arg Pro  Pro Ser Lys 
    1370                 1375                 1380             


Phe Phe  Lys Gln Met Glu Gln  Arg Tyr Leu Xaa Gln  Leu Xaa Ala 
    1385                 1390                 1395             


Gln Pro  Val Pro Pro Glu Met  Cys Ser Gly Trp Trp  Trp Ile Arg 
    1400                 1405                 1410             


Asp Pro  Glu Met Leu Asp Ala  Met Leu Lys Ala Leu  His Pro Arg 
    1415                 1420                 1425             


Gly Ile  Arg Glu Lys Ala Leu  His Lys His Leu Asn  Lys His Arg 
    1430                 1435                 1440             


Asp Phe  Leu Gln Glu Val Cys  Leu Arg Pro Ser Ala  Asp Pro Ile 
    1445                 1450                 1455             


Phe Glu  Pro Arg Gln Leu Pro  Ala Phe Gln Glu Gly  Ile Met Ser 
    1460                 1465                 1470             


Trp Ser  Pro Lys Glu Lys Xaa  Tyr Glu Xaa Asp Leu  Ala Val Leu 
    1475                 1480                 1485             


Gln Trp  Val Glu Glu Leu Glu  Gln Arg Val Ile Met  Ser Asp Leu 
    1490                 1495                 1500             


Gln Ile  Arg Gly Trp Xaa Cys  Pro Ser Pro Asp Ser  Xaa Arg Glu 
    1505                 1510                 1515             


Asp Leu  Ala Tyr Cys Glu His  Leu Ser Asp Ser Gln  Glu Asp Ile 
    1520                 1525                 1530             


Xaa Trp  Arg Gly Arg Gly Arg  Glu Gly Leu Ala Pro  Gln Arg Lys 
    1535                 1540                 1545             


Xaa Xaa  Asn Pro Leu Asp Leu  Ala Val Met Arg Leu  Ala Ala Leu 
    1550                 1555                 1560             


Glu Gln  Asn Val Glu Arg Arg  Tyr Leu Arg Glu Pro  Leu Trp Pro 
    1565                 1570                 1575             


Xaa His  Glu Val Val Leu Glu  Lys Ala Leu Leu Ser  Xaa Pro Asn 
    1580                 1585                 1590             


Gly Ala  Pro Glu Gly Xaa Xaa  Xaa Glu Ile Ser Tyr  Glu Ile Xaa 
    1595                 1600                 1605             


Pro Arg  Ile Arg Val Trp Arg  Gln Xaa Leu Glu Arg  Cys Arg Ser 
    1610                 1615                 1620             


Ala Ala  Gln Val Cys Leu Cys  Leu Gly Gln Leu Glu  Arg Ser Ile 
    1625                 1630                 1635             


Ala Trp  Glu Lys Ser Val Asn  Lys Val Xaa Cys Leu  Val Cys Arg 
    1640                 1645                 1650             


Lys Gly  Asp Asn Asp Glu Phe  Leu Leu Leu Cys Asp  Gly Cys Asp 
    1655                 1660                 1665             


Arg Gly  Cys His Ile Tyr Cys  His Arg Pro Lys Met  Glu Ala Val 
    1670                 1675                 1680             


Pro Glu  Gly Asp Trp Phe Cys  Xaa Val Cys Leu Ala  Gln Gln Val 
    1685                 1690                 1695             


Glu Gly  Glu Phe Xaa Gln Lys  Pro Gly Phe Pro Lys  Arg Gly Gln 
    1700                 1705                 1710             


Lys Arg  Lys Ser Gly Tyr Ser  Leu Asn Phe Ser Glu  Gly Asp Gly 
    1715                 1720                 1725             


Arg Arg  Arg Arg Val Leu Leu  Arg Gly Arg Glu Ser  Pro Ala Ala 
    1730                 1735                 1740             


Gly Pro  Arg Tyr Ser Glu Glu  Gly Leu Ser Pro Ser  Lys Arg Arg 
    1745                 1750                 1755             


Arg Leu  Ser Met Arg Asn His  His Ser Asp Leu Xaa  Phe Cys Glu 
    1760                 1765                 1770             


Ile Ile  Leu Met Glu Met Glu  Ser His Asp Ala Ala  Trp Pro Phe 
    1775                 1780                 1785             


Leu Glu  Pro Val Asn Pro Arg  Leu Val Ser Gly Tyr  Arg Arg Ile 
    1790                 1795                 1800             


Ile Lys  Asn Pro Met Asp Phe  Ser Xaa Met Arg Glu  Arg Leu Leu 
    1805                 1810                 1815             


Arg Gly  Gly Tyr Xaa Ser Ser  Glu Glu Phe Ala Ala  Asp Ala Leu 
    1820                 1825                 1830             


Leu Val  Phe Asp Asn Cys Gln  Xaa Phe Asn Glu Asp  Asp Ser Glu 
    1835                 1840                 1845             


Val Gly  Lys Ala Gly His Ile  Met Arg Arg Phe Phe  Glu Ser Arg 
    1850                 1855                 1860             


Trp Glu  Glu Phe Tyr Gln Gly  Lys Gln Ala Asn Leu  
    1865                 1870                 1875 


<210> 3962
<211> 1905
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1195)..(1195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1276)..(1276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1377)..(1377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1399)..(1399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1424)..(1424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1510)..(1510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1539)..(1539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1546)..(1546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1564)..(1564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1579)..(1580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1629)..(1631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1638)..(1638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1647)..(1647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1678)..(1678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1733)..(1733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1800)..(1800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1842)..(1842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1853)..(1853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1871)..(1871)
<223> Selenocysteine

<400> 3962
Met Glu Met Glu Ala Asn Asp His Phe Asn Phe Xaa Gly Leu Pro Pro 
1               5                   10                  15      


Ala Pro Ala Ala Ser Gly Leu Lys Pro Ser Pro Ser Ser Gly Glu Gly 
            20                  25                  30          


Leu Tyr Xaa Asn Gly Ser Pro Met Asn Phe Pro Gln Gln Gly Lys Ser 
        35                  40                  45              


Leu Asn Gly Asp Val Asn Val Asn Gly Leu Ser Xaa Val Ser His Xaa 
    50                  55                  60                  


Xaa Xaa Ser Gly Ile Leu Asn Ser Ala Pro His Ser Ser Ser Xaa Ser 
65                  70                  75                  80  


His Leu His His Pro Ser Val Ala Tyr Asp Cys Leu Trp Asn Tyr Ser 
                85                  90                  95      


Gln Tyr Pro Ser Ala Asn Pro Gly Ser Asn Leu Lys Asp Pro Pro Leu 
            100                 105                 110         


Leu Ser Gln Phe Ser Gly Gly Gln Tyr Pro Leu Asn Gly Ile Leu Gly 
        115                 120                 125             


Gly Ser Arg Gln Pro Ser Ser Pro Ser His Asn Xaa Asn Leu Arg Ala 
    130                 135                 140                 


Gly Ser Gln Glu Phe Trp Ala Asn Gly Xaa Gln Ser Pro Met Gly Leu 
145                 150                 155                 160 


Asn Phe Asp Ser Gln Glu Leu Tyr Asp Ser Phe Pro Asp Gln Asn Phe 
                165                 170                 175     


Glu Val Met Pro Asn Gly Pro Pro Ser Phe Phe Xaa Ser Pro Gln Xaa 
            180                 185                 190         


Ser Pro Met Leu Gly Ser Ser Ile Gln Xaa Phe Ala Pro Ser Gln Glu 
        195                 200                 205             


Val Gly Ser Gly Ile His Pro Asp Glu Ala Ala Glu Lys Glu Met Xaa 
    210                 215                 220                 


Ser Val Val Ala Glu Asn Gly Xaa Gly Leu Val Gly Ser Leu Glu Leu 
225                 230                 235                 240 


Glu Glu Glu Gln Pro Glu Leu Lys Met Cys Gly Tyr Asn Gly Ser Val 
                245                 250                 255     


Pro Ser Val Glu Ser Leu His Gln Glu Val Ser Val Leu Val Pro Asp 
            260                 265                 270         


Pro Xaa Val Ser Cys Leu Asp Asp Pro Ser His Leu Pro Asp Gln Leu 
        275                 280                 285             


Glu Asp Xaa Pro Ile Leu Ser Glu Asp Ser Leu Glu Pro Phe Asn Ser 
    290                 295                 300                 


Leu Ala Pro Glu Pro Val Ser Gly Gly Leu Tyr Gly Ile Asp Asp Xaa 
305                 310                 315                 320 


Glu Leu Met Gly Ala Glu Asp Lys Leu Pro Leu Glu Asp Ser Pro Val 
                325                 330                 335     


Ile Ser Ala Leu Asp Cys Pro Ser Leu Asn Asn Ala Xaa Ala Phe Ser 
            340                 345                 350         


Leu Leu Ala Asp Asp Ser Gln Xaa Ser Xaa Ser Ile Phe Ala Ser Pro 
        355                 360                 365             


Xaa Ser Pro Pro Val Leu Gly Glu Ser Val Leu Gln Asp Asn Ser Phe 
    370                 375                 380                 


Asp Leu Asn Asn Gly Ser Asp Ala Glu Gln Glu Glu Met Glu Xaa Gln 
385                 390                 395                 400 


Ser Ser Asp Phe Pro Pro Ser Leu Xaa Gln Pro Ala Pro Asp Gln Ser 
                405                 410                 415     


Ser Xaa Ile Gln Leu His Pro Ala Xaa Ser Pro Ala Val Ser Pro Xaa 
            420                 425                 430         


Xaa Ser Pro Ala Val Ser Leu Val Val Ser Pro Ala Ala Ser Pro Glu 
        435                 440                 445             


Ile Ser Pro Glu Val Cys Pro Ala Ala Ser Xaa Val Val Ser Pro Ala 
    450                 455                 460                 


Val Phe Ser Val Val Ser Pro Ala Ser Ser Ala Val Leu Pro Ala Val 
465                 470                 475                 480 


Ser Leu Glu Val Pro Leu Xaa Ala Ser Val Xaa Ser Pro Lys Ala Ser 
                485                 490                 495     


Pro Val Xaa Ser Pro Ala Ala Ala Phe Pro Xaa Ala Ser Pro Ala Asn 
            500                 505                 510         


Lys Asp Val Ser Ser Phe Leu Glu Xaa Xaa Ala Asp Val Glu Glu Ile 
        515                 520                 525             


Xaa Gly Glu Gly Leu Xaa Ala Ser Gly Ser Gly Asp Val Met Arg Arg 
    530                 535                 540                 


Arg Ile Ala Xaa Pro Glu Glu Val Arg Leu Pro Leu Gln His Gly Trp 
545                 550                 555                 560 


Arg Arg Glu Val Arg Ile Lys Lys Gly Ser His Arg Trp Gln Gly Glu 
                565                 570                 575     


Xaa Trp Tyr Tyr Gly Pro Cys Gly Lys Arg Met Lys Gln Phe Pro Glu 
            580                 585                 590         


Val Ile Lys Tyr Leu Ser Arg Asn Val Val His Ser Val Arg Arg Glu 
        595                 600                 605             


His Phe Ser Phe Ser Pro Arg Met Pro Val Gly Asp Phe Phe Glu Glu 
    610                 615                 620                 


Arg Asp Xaa Pro Glu Gly Leu Gln Trp Val Gln Leu Ser Ala Glu Glu 
625                 630                 635                 640 


Ile Pro Ser Arg Ile Gln Ala Ile Xaa Gly Lys Arg Gly Arg Pro Arg 
                645                 650                 655     


Asn Xaa Glu Lys Ala Lys Xaa Lys Glu Val Pro Lys Val Lys Arg Gly 
            660                 665                 670         


Arg Gly Arg Pro Pro Lys Val Lys Ile Xaa Glu Leu Leu Asn Lys Xaa 
        675                 680                 685             


Asp Asn Arg Pro Leu Lys Lys Leu Glu Ala Gln Glu Xaa Leu Asn Glu 
    690                 695                 700                 


Glu Asp Lys Ala Lys Ile Ala Lys Ser Lys Lys Lys Met Arg Gln Lys 
705                 710                 715                 720 


Val Gln Arg Gly Glu Cys Gln Xaa Xaa Ile Gln Gly Gln Ala Arg Asn 
                725                 730                 735     


Lys Arg Lys Gln Glu Xaa Lys Ser Leu Lys Gln Lys Glu Ala Lys Lys 
            740                 745                 750         


Lys Ser Lys Ala Glu Lys Glu Lys Gly Lys Xaa Lys Gln Glu Lys Leu 
        755                 760                 765             


Lys Glu Lys Val Lys Arg Glu Lys Lys Glu Lys Val Lys Met Lys Glu 
    770                 775                 780                 


Lys Glu Glu Val Xaa Lys Ala Lys Pro Ala Cys Lys Ala Asp Lys Xaa 
785                 790                 795                 800 


Leu Ala Xaa Gln Arg Arg Leu Glu Glu Arg Gln Arg Gln Gln Met Ile 
                805                 810                 815     


Leu Glu Glu Met Lys Lys Pro Xaa Glu Asp Met Cys Leu Xaa Asp His 
            820                 825                 830         


Gln Pro Leu Pro Asp Phe Ser Arg Val Pro Gly Leu Xaa Leu Pro Ser 
        835                 840                 845             


Gly Ala Phe Ser Asp Cys Leu Xaa Ile Val Glu Phe Leu His Ser Phe 
    850                 855                 860                 


Gly Lys Val Leu Gly Phe Asp Pro Ala Lys Asp Val Pro Ser Leu Gly 
865                 870                 875                 880 


Val Leu Gln Glu Gly Leu Leu Cys Gln Gly Asp Ser Leu Gly Glu Val 
                885                 890                 895     


Gln Asp Leu Leu Val Arg Leu Leu Lys Ala Ala Leu His Asp Pro Gly 
            900                 905                 910         


Phe Pro Ser Tyr Cys Gln Ser Leu Lys Ile Leu Gly Glu Lys Val Ser 
        915                 920                 925             


Glu Ile Pro Leu Xaa Arg Asp Asn Val Ser Glu Ile Leu Arg Cys Phe 
    930                 935                 940                 


Leu Met Ala Tyr Gly Val Glu Pro Ala Leu Cys Asp Arg Leu Arg Xaa 
945                 950                 955                 960 


Gln Pro Phe Gln Ala Gln Pro Pro Gln Gln Lys Ala Ala Val Leu Ala 
                965                 970                 975     


Phe Leu Val His Glu Leu Asn Gly Ser Xaa Leu Ile Ile Asn Glu Ile 
            980                 985                 990         


Asp Lys Xaa Leu Glu Ser Met Ser  Ser Tyr Arg Lys Asn  Lys Trp Ile 
        995                 1000                 1005             


Val Glu  Gly Arg Leu Arg Arg  Leu Lys Xaa Val Leu  Ala Lys Arg 
    1010                 1015                 1020             


Xaa Gly  Arg Ser Glu Val Glu  Met Glu Gly Pro Glu  Glu Cys Leu 
    1025                 1030                 1035             


Gly Arg  Arg Arg Ser Ser Arg  Ile Met Glu Glu Xaa  Ser Gly Met 
    1040                 1045                 1050             


Glu Glu  Glu Glu Glu Glu Glu  Ser Ile Ala Ala Val  Pro Gly Arg 
    1055                 1060                 1065             


Arg Gly  Arg Arg Asp Gly Glu  Val Asp Ala Xaa Ala  Ser Ser Ile 
    1070                 1075                 1080             


Pro Glu  Leu Glu Arg Gln Ile  Glu Lys Leu Ser Lys  Arg Gln Leu 
    1085                 1090                 1095             


Phe Phe  Arg Lys Lys Leu Leu  His Ser Ser Gln Met  Leu Arg Ala 
    1100                 1105                 1110             


Val Ser  Leu Gly Gln Asp Arg  Tyr Arg Arg Arg Tyr  Trp Val Leu 
    1115                 1120                 1125             


Pro Tyr  Leu Ala Gly Ile Phe  Val Glu Gly Xaa Glu  Gly Asn Leu 
    1130                 1135                 1140             


Val Pro  Glu Glu Val Ile Lys  Lys Glu Xaa Asp Ser  Leu Lys Val 
    1145                 1150                 1155             


Ala Ala  His Ala Ser Leu Asn  Pro Ala Leu Phe Ser  Met Lys Met 
    1160                 1165                 1170             


Glu Leu  Ala Gly Ser Asn Xaa  Xaa Ala Ser Ser Pro  Ala Arg Ala 
    1175                 1180                 1185             


Arg Gly  Arg Pro Arg Lys Xaa  Lys Pro Gly Ser Met  Gln Pro Arg 
    1190                 1195                 1200             


His Leu  Lys Ser Pro Val Arg  Gly Gln Asp Ser Glu  Gln Pro Gln 
    1205                 1210                 1215             


Ala Gln  Leu Gln Pro Glu Ala  Gln Leu His Ala Pro  Ala Gln Pro 
    1220                 1225                 1230             


Gln Pro  Gln Leu Gln Leu Gln  Leu Gln Ser His Lys  Gly Phe Leu 
    1235                 1240                 1245             


Glu Gln  Glu Gly Ser Pro Leu  Ser Leu Gly Gln Ser  Gln His Asp 
    1250                 1255                 1260             


Leu Ser  Gln Ser Ala Phe Leu  Ser Trp Leu Ser Gln  Xaa Gln Ser 
    1265                 1270                 1275             


His Ser  Ser Leu Leu Ser Ser  Ser Val Leu Xaa Pro  Asp Ser Ser 
    1280                 1285                 1290             


Pro Gly  Lys Leu Asp Pro Ala  Pro Ser Gln Pro Pro  Glu Glu Pro 
    1295                 1300                 1305             


Glu Pro  Asp Glu Ala Glu Ser  Ser Pro Asp Pro Gln  Ala Leu Trp 
    1310                 1315                 1320             


Phe Asn  Ile Ser Ala Gln Met  Pro Cys Asn Ala Ala  Pro Xaa Pro 
    1325                 1330                 1335             


Pro Pro  Ala Val Ser Glu Asp  Gln Pro Xaa Pro Ser  Pro Gln Gln 
    1340                 1345                 1350             


Leu Ala  Ser Ser Lys Pro Met  Asn Arg Pro Ser Ala  Ala Asn Pro 
    1355                 1360                 1365             


Cys Ser  Pro Val Gln Phe Ser  Ser Xaa Pro Leu Ala  Gly Leu Ala 
    1370                 1375                 1380             


Pro Lys  Arg Arg Ala Gly Asp  Pro Gly Glu Met Pro  Gln Ser Pro 
    1385                 1390                 1395             


Xaa Gly  Leu Gly Gln Pro Lys  Arg Arg Gly Arg Pro  Pro Ser Lys 
    1400                 1405                 1410             


Phe Phe  Lys Gln Met Glu Gln  Arg Tyr Leu Xaa Gln  Leu Xaa Ala 
    1415                 1420                 1425             


Gln Pro  Val Pro Pro Glu Met  Cys Ser Gly Trp Trp  Trp Ile Arg 
    1430                 1435                 1440             


Asp Pro  Glu Met Leu Asp Ala  Met Leu Lys Ala Leu  His Pro Arg 
    1445                 1450                 1455             


Gly Ile  Arg Glu Lys Ala Leu  His Lys His Leu Asn  Lys His Arg 
    1460                 1465                 1470             


Asp Phe  Leu Gln Glu Val Cys  Leu Arg Pro Ser Ala  Asp Pro Ile 
    1475                 1480                 1485             


Phe Glu  Pro Arg Gln Leu Pro  Ala Phe Gln Glu Gly  Ile Met Ser 
    1490                 1495                 1500             


Trp Ser  Pro Lys Glu Lys Xaa  Tyr Glu Xaa Asp Leu  Ala Val Leu 
    1505                 1510                 1515             


Gln Trp  Val Glu Glu Leu Glu  Gln Arg Val Ile Met  Ser Asp Leu 
    1520                 1525                 1530             


Gln Ile  Arg Gly Trp Xaa Cys  Pro Ser Pro Asp Ser  Xaa Arg Glu 
    1535                 1540                 1545             


Asp Leu  Ala Tyr Cys Glu His  Leu Ser Asp Ser Gln  Glu Asp Ile 
    1550                 1555                 1560             


Xaa Trp  Arg Gly Arg Gly Arg  Glu Gly Leu Ala Pro  Gln Arg Lys 
    1565                 1570                 1575             


Xaa Xaa  Asn Pro Leu Asp Leu  Ala Val Met Arg Leu  Ala Ala Leu 
    1580                 1585                 1590             


Glu Gln  Asn Val Glu Arg Arg  Tyr Leu Arg Glu Pro  Leu Trp Pro 
    1595                 1600                 1605             


Xaa His  Glu Val Val Leu Glu  Lys Ala Leu Leu Ser  Xaa Pro Asn 
    1610                 1615                 1620             


Gly Ala  Pro Glu Gly Xaa Xaa  Xaa Glu Ile Ser Tyr  Glu Ile Xaa 
    1625                 1630                 1635             


Pro Arg  Ile Arg Val Trp Arg  Gln Xaa Leu Glu Arg  Cys Arg Ser 
    1640                 1645                 1650             


Ala Ala  Gln Val Cys Leu Cys  Leu Gly Gln Leu Glu  Arg Ser Ile 
    1655                 1660                 1665             


Ala Trp  Glu Lys Ser Val Asn  Lys Val Xaa Cys Leu  Val Cys Arg 
    1670                 1675                 1680             


Lys Gly  Asp Asn Asp Glu Phe  Leu Leu Leu Cys Asp  Gly Cys Asp 
    1685                 1690                 1695             


Arg Gly  Cys His Ile Tyr Cys  His Arg Pro Lys Met  Glu Ala Val 
    1700                 1705                 1710             


Pro Glu  Gly Asp Trp Phe Cys  Xaa Val Cys Leu Ala  Gln Gln Val 
    1715                 1720                 1725             


Glu Gly  Glu Phe Xaa Gln Lys  Pro Gly Phe Pro Lys  Arg Gly Gln 
    1730                 1735                 1740             


Lys Arg  Lys Ser Gly Tyr Ser  Leu Asn Phe Ser Glu  Gly Asp Gly 
    1745                 1750                 1755             


Arg Arg  Arg Arg Val Leu Leu  Arg Gly Arg Glu Ser  Pro Ala Ala 
    1760                 1765                 1770             


Gly Pro  Arg Tyr Ser Glu Glu  Gly Leu Ser Pro Ser  Lys Arg Arg 
    1775                 1780                 1785             


Arg Leu  Ser Met Arg Asn His  His Ser Asp Leu Xaa  Phe Cys Glu 
    1790                 1795                 1800             


Ile Ile  Leu Met Glu Met Glu  Ser His Asp Ala Ala  Trp Pro Phe 
    1805                 1810                 1815             


Leu Glu  Pro Val Asn Pro Arg  Leu Val Ser Gly Tyr  Arg Arg Ile 
    1820                 1825                 1830             


Ile Lys  Asn Pro Met Asp Phe  Ser Xaa Met Arg Glu  Arg Leu Leu 
    1835                 1840                 1845             


Arg Gly  Gly Tyr Xaa Ser Ser  Glu Glu Phe Ala Ala  Asp Ala Leu 
    1850                 1855                 1860             


Leu Val  Phe Asp Asn Cys Gln  Xaa Phe Asn Glu Asp  Asp Ser Glu 
    1865                 1870                 1875             


Val Gly  Lys Ala Gly His Ile  Met Arg Arg Phe Phe  Glu Ser Arg 
    1880                 1885                 1890             


Trp Glu  Glu Phe Tyr Gln Gly  Lys Gln Ala Asn Leu  
    1895                 1900                 1905 


<210> 3963
<211> 837
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<400> 3963
Val Pro Gly Arg Arg Gly Arg Arg Asp Gly Glu Val Asp Ala Xaa Ala 
1               5                   10                  15      


Ser Ser Ile Pro Glu Leu Glu Arg Gln Ile Glu Lys Leu Ser Lys Arg 
            20                  25                  30          


Gln Leu Phe Phe Arg Lys Lys Leu Leu His Ser Ser Gln Met Leu Arg 
        35                  40                  45              


Ala Val Ser Leu Gly Gln Asp Arg Tyr Arg Arg Arg Tyr Trp Val Leu 
    50                  55                  60                  


Pro Tyr Leu Ala Gly Ile Phe Val Glu Gly Xaa Glu Gly Asn Leu Val 
65                  70                  75                  80  


Pro Glu Glu Val Ile Lys Lys Glu Xaa Asp Ser Leu Lys Val Ala Ala 
                85                  90                  95      


His Ala Ser Leu Asn Pro Ala Leu Phe Ser Met Lys Met Glu Leu Ala 
            100                 105                 110         


Gly Ser Asn Xaa Xaa Ala Ser Ser Pro Ala Arg Ala Arg Gly Arg Pro 
        115                 120                 125             


Arg Lys Xaa Lys Pro Gly Ser Met Gln Pro Arg His Leu Lys Ser Pro 
    130                 135                 140                 


Val Arg Gly Gln Asp Ser Glu Gln Pro Gln Ala Gln Leu Gln Pro Glu 
145                 150                 155                 160 


Ala Gln Leu His Ala Pro Ala Gln Pro Gln Pro Gln Leu Gln Leu Gln 
                165                 170                 175     


Leu Gln Ser His Lys Gly Phe Leu Glu Gln Glu Gly Ser Pro Leu Ser 
            180                 185                 190         


Leu Gly Gln Ser Gln His Asp Leu Ser Gln Ser Ala Phe Leu Ser Trp 
        195                 200                 205             


Leu Ser Gln Xaa Gln Ser His Ser Ser Leu Leu Ser Ser Ser Val Leu 
    210                 215                 220                 


Xaa Pro Asp Ser Ser Pro Gly Lys Leu Asp Pro Ala Pro Ser Gln Pro 
225                 230                 235                 240 


Pro Glu Glu Pro Glu Pro Asp Glu Ala Glu Ser Ser Pro Asp Pro Gln 
                245                 250                 255     


Ala Leu Trp Phe Asn Ile Ser Ala Gln Met Pro Cys Asn Ala Ala Pro 
            260                 265                 270         


Xaa Pro Pro Pro Ala Val Ser Glu Asp Gln Pro Xaa Pro Ser Pro Gln 
        275                 280                 285             


Gln Leu Ala Ser Ser Lys Pro Met Asn Arg Pro Ser Ala Ala Asn Pro 
    290                 295                 300                 


Cys Ser Pro Val Gln Phe Ser Ser Xaa Pro Leu Ala Gly Leu Ala Pro 
305                 310                 315                 320 


Lys Arg Arg Ala Gly Asp Pro Gly Glu Met Pro Gln Ser Pro Xaa Gly 
                325                 330                 335     


Leu Gly Gln Pro Lys Arg Arg Gly Arg Pro Pro Ser Lys Phe Phe Lys 
            340                 345                 350         


Gln Met Glu Gln Arg Tyr Leu Xaa Gln Leu Xaa Ala Gln Pro Val Pro 
        355                 360                 365             


Pro Gly Trp Trp Trp Ile Arg Asp Pro Glu Met Leu Asp Ala Met Leu 
    370                 375                 380                 


Lys Ala Leu His Pro Arg Gly Ile Arg Glu Lys Ala Leu His Lys His 
385                 390                 395                 400 


Leu Asn Lys His Arg Asp Phe Leu Gln Glu Val Cys Leu Arg Pro Ser 
                405                 410                 415     


Ala Asp Pro Ile Phe Glu Pro Arg Gln Leu Pro Ala Phe Gln Glu Gly 
            420                 425                 430         


Ile Met Ser Trp Ser Pro Lys Glu Lys Xaa Tyr Glu Xaa Asp Leu Ala 
        435                 440                 445             


Val Leu Gln Trp Val Glu Glu Leu Glu Gln Arg Val Ile Met Ser Asp 
    450                 455                 460                 


Leu Gln Ile Arg Gly Trp Xaa Cys Pro Ser Pro Asp Ser Xaa Arg Glu 
465                 470                 475                 480 


Asp Leu Ala Tyr Cys Glu His Leu Ser Asp Ser Gln Glu Asp Ile Xaa 
                485                 490                 495     


Trp Arg Gly Arg Gly Arg Glu Gly Leu Ala Pro Gln Arg Lys Xaa Xaa 
            500                 505                 510         


Asn Pro Leu Asp Leu Ala Val Met Arg Leu Ala Ala Leu Glu Gln Asn 
        515                 520                 525             


Val Glu Arg Arg Tyr Leu Arg Glu Pro Leu Trp Pro Xaa His Glu Val 
    530                 535                 540                 


Val Leu Glu Lys Ala Leu Leu Ser Xaa Pro Asn Gly Ala Pro Glu Gly 
545                 550                 555                 560 


Xaa Xaa Xaa Glu Ile Ser Tyr Glu Ile Xaa Pro Arg Ile Arg Val Trp 
                565                 570                 575     


Arg Gln Xaa Leu Glu Arg Cys Arg Ser Ala Ala Gln Val Cys Leu Cys 
            580                 585                 590         


Leu Gly Gln Leu Glu Arg Ser Ile Ala Trp Glu Lys Ser Val Asn Lys 
        595                 600                 605             


Val Xaa Cys Leu Val Cys Arg Lys Gly Asp Asn Asp Glu Phe Leu Leu 
    610                 615                 620                 


Leu Cys Asp Gly Cys Asp Arg Gly Cys His Ile Tyr Cys His Arg Pro 
625                 630                 635                 640 


Lys Met Glu Ala Val Pro Glu Gly Asp Trp Phe Cys Xaa Val Cys Leu 
                645                 650                 655     


Ala Gln Gln Val Glu Gly Glu Phe Xaa Gln Lys Pro Gly Phe Pro Lys 
            660                 665                 670         


Arg Gly Gln Lys Arg Lys Ser Gly Tyr Ser Leu Asn Phe Ser Glu Gly 
        675                 680                 685             


Asp Gly Arg Arg Arg Arg Val Leu Leu Arg Gly Arg Glu Ser Pro Ala 
    690                 695                 700                 


Ala Gly Pro Arg Tyr Ser Glu Glu Gly Leu Ser Pro Ser Lys Arg Arg 
705                 710                 715                 720 


Arg Leu Ser Met Arg Asn His His Ser Asp Leu Xaa Phe Cys Glu Ile 
                725                 730                 735     


Ile Leu Met Glu Met Glu Ser His Asp Ala Ala Trp Pro Phe Leu Glu 
            740                 745                 750         


Pro Val Asn Pro Arg Leu Val Ser Gly Tyr Arg Arg Ile Ile Lys Asn 
        755                 760                 765             


Pro Met Asp Phe Ser Xaa Met Arg Glu Arg Leu Leu Arg Gly Gly Tyr 
    770                 775                 780                 


Xaa Ser Ser Glu Glu Phe Ala Ala Asp Ala Leu Leu Val Phe Asp Asn 
785                 790                 795                 800 


Cys Gln Xaa Phe Asn Glu Asp Asp Ser Glu Val Gly Lys Ala Gly His 
                805                 810                 815     


Ile Met Arg Arg Phe Phe Glu Ser Arg Trp Glu Glu Phe Tyr Gln Gly 
            820                 825                 830         


Lys Gln Ala Asn Leu 
        835         


<210> 3964
<211> 277
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<400> 3964
Xaa Leu Ala Asp Asp Ser Gln Xaa Ser Xaa Ser Ile Phe Ala Ser Pro 
1               5                   10                  15      


Xaa Ser Pro Pro Val Leu Gly Glu Ser Val Leu Gln Asp Asn Ser Phe 
            20                  25                  30          


Asp Leu Asn Asn Gly Ser Asp Ala Glu Gln Glu Glu Met Glu Xaa Gln 
        35                  40                  45              


Ser Ser Asp Phe Pro Pro Ser Leu Xaa Gln Pro Ala Pro Asp Gln Ser 
    50                  55                  60                  


Ser Xaa Ile Gln Leu His Pro Ala Xaa Ser Pro Ala Val Ser Pro Xaa 
65                  70                  75                  80  


Xaa Ser Pro Ala Val Ser Leu Val Val Ser Pro Ala Ala Ser Pro Glu 
                85                  90                  95      


Ile Ser Pro Glu Val Cys Pro Ala Ala Ser Xaa Val Val Ser Pro Ala 
            100                 105                 110         


Val Phe Ser Val Val Ser Pro Ala Ser Ser Ala Val Leu Pro Ala Val 
        115                 120                 125             


Ser Leu Glu Val Pro Leu Xaa Ala Ser Val Xaa Ser Pro Lys Ala Ser 
    130                 135                 140                 


Pro Val Xaa Ser Pro Ala Ala Ala Phe Pro Xaa Ala Ser Pro Ala Asn 
145                 150                 155                 160 


Lys Asp Val Ser Ser Phe Leu Glu Xaa Xaa Ala Asp Val Glu Glu Ile 
                165                 170                 175     


Xaa Gly Glu Gly Leu Xaa Ala Ser Gly Ser Gly Asp Val Met Arg Arg 
            180                 185                 190         


Arg Ile Ala Xaa Pro Glu Glu Val Arg Leu Pro Leu Gln His Gly Ala 
        195                 200                 205             


His Val Leu Leu Trp Gln Val Ala Glu Arg Gly Ala His Gln Glu Gly 
    210                 215                 220                 


Gln Pro Pro Met Ala Gly Gly Asp Leu Val Leu Trp Pro Leu Trp Glu 
225                 230                 235                 240 


Glu Asp Glu Ala Ile Ser Arg Ser Asp Gln Val Pro Glu Pro Gln Arg 
                245                 250                 255     


Gly Xaa Gln Cys Pro Pro Arg Ala Leu Gln Leu Gln Ser Pro Tyr Ala 
            260                 265                 270         


Cys Trp Arg Phe Leu 
        275         


<210> 3965
<211> 162
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<400> 3965
Xaa Asn Ala Ala Pro Xaa Pro Pro Pro Ala Val Ser Glu Asp Gln Pro 
1               5                   10                  15      


Xaa Pro Ser Pro Gln Gln Leu Ala Ser Ser Lys Pro Met Asn Arg Pro 
            20                  25                  30          


Ser Ala Ala Asn Pro Cys Ser Pro Val Gln Phe Ser Ser Xaa Pro Leu 
        35                  40                  45              


Ala Gly Leu Ala Pro Lys Arg Arg Ala Gly Asp Pro Gly Glu Met Pro 
    50                  55                  60                  


Gln Ser Pro Xaa Gly Leu Gly Gln Pro Lys Arg Arg Gly Arg Pro Pro 
65                  70                  75                  80  


Lys Met Cys Ser Gly Trp Trp Trp Ile Arg Asp Pro Glu Met Leu Asp 
                85                  90                  95      


Ala Met Leu Lys Ala Leu His Pro Arg Gly Ile Arg Glu Lys Ala Leu 
            100                 105                 110         


His Lys His Leu Asn Lys His Arg Asp Phe Leu Gln Glu Val Cys Leu 
        115                 120                 125             


Arg Pro Ser Ala Asp Pro Ile Phe Glu Pro Arg Gln Leu Pro Ala Phe 
    130                 135                 140                 


Gln Glu Gly Ile Met Ser Trp Ser Pro Lys Glu Lys Xaa Tyr Glu Xaa 
145                 150                 155                 160 


Asp Leu 
        


<210> 3966
<211> 205
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<400> 3966
Xaa Trp Gln Gly Glu Xaa Trp Tyr Tyr Gly Pro Cys Gly Lys Arg Met 
1               5                   10                  15      


Lys Gln Phe Pro Glu Val Ile Lys Tyr Leu Ser Arg Asn Val Val His 
            20                  25                  30          


Ser Val Arg Arg Glu His Phe Ser Phe Ser Pro Arg Met Pro Val Gly 
        35                  40                  45              


Asp Phe Phe Glu Glu Arg Asp Xaa Pro Glu Trp Val Gln Leu Ser Ala 
    50                  55                  60                  


Glu Glu Ile Pro Ser Arg Ile Gln Ala Ile Xaa Gly Lys Arg Gly Arg 
65                  70                  75                  80  


Pro Arg Asn Xaa Glu Lys Ala Lys Xaa Lys Glu Val Pro Lys Val Lys 
                85                  90                  95      


Arg Gly Arg Gly Arg Pro Pro Lys Val Lys Ile Xaa Glu Leu Leu Asn 
            100                 105                 110         


Lys Xaa Asp Asn Arg Pro Leu Lys Lys Leu Glu Ala Gln Glu Xaa Leu 
        115                 120                 125             


Asn Glu Glu Asp Lys Ala Lys Ile Ala Lys Ser Lys Lys Lys Met Arg 
    130                 135                 140                 


Gln Lys Val Gln Arg Gly Glu Cys Gln Xaa Xaa Ile Gln Gly Gln Ala 
145                 150                 155                 160 


Arg Asn Lys Arg Lys Gln Glu Xaa Lys Ser Leu Lys Gln Lys Glu Ala 
                165                 170                 175     


Lys Lys Lys Ser Lys Ala Glu Lys Glu Lys Gly Lys Xaa Lys Gln Glu 
            180                 185                 190         


Lys Leu Lys Glu Lys Val Lys Arg Glu Lys Lys Glu Lys 
        195                 200                 205 


<210> 3967
<211> 2132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1247)..(1247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1293)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1395)..(1395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1405)..(1405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1461)..(1461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1478)..(1478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1480)..(1480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1495)..(1495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1515)..(1515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1517)..(1517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1530)..(1530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1535)..(1535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1538)..(1538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1544)..(1544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1549)..(1549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1562)..(1562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1602)..(1602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1612)..(1612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1634)..(1634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1653)..(1653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1720)..(1720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1743)..(1743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1805)..(1805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1816)..(1816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1839)..(1839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1922)..(1922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1930)..(1931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1950)..(1950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1963)..(1963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1973)..(1973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1975)..(1975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1978)..(1978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1986)..(1986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2006)..(2006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2017)..(2017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2038)..(2038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2042)..(2042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2073)..(2073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2088)..(2088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2102)..(2102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2126)..(2126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2128)..(2128)
<223> Selenocysteine

<400> 3967
Met Glu Ser Gly Glu Arg Leu Pro Ser Ser Ala Ala Ser Ser Xaa Xaa 
1               5                   10                  15      


Pro Xaa Ser Ser Ser Xaa Pro Ser Val Ala Ser Val Val Ser Lys Gly 
            20                  25                  30          


Gly Leu Ser Xaa Gly Val Ala Ser Leu Ser Ser Xaa Ile Asn Pro Cys 
        35                  40                  45              


Gly His Leu Phe Arg Xaa Ala Gly Asp Gln Pro Phe Asn Leu Ser Xaa 
    50                  55                  60                  


Val Ser Ser Ala Phe Pro Met Val Ser His Pro Val Phe Gly Leu His 
65                  70                  75                  80  


Ser Ala Ser Ser Gly His Ser Glu Phe Gly Gly Leu Gly Xaa Leu Gly 
                85                  90                  95      


Xaa Pro Xaa Ala Leu Ala Ala His Pro Gln Leu Ala Ser Phe Pro Glu 
            100                 105                 110         


Trp Trp Arg Xaa Xaa Asp Ala His Xaa Arg Xaa Gly Ala Xaa Phe Phe 
        115                 120                 125             


Pro Pro Leu Leu Gly Ile Pro Pro Leu Phe Ala Pro Pro Ala Gln Asn 
    130                 135                 140                 


His Asp Ser Ser Ser Phe His Ser Arg Xaa Ser Gly Lys Ser Asn Arg 
145                 150                 155                 160 


Asn Gly Pro Glu Lys Gly Val Asn Gly Ser Ile Asn Gly Ser Asn Xaa 
                165                 170                 175     


Ser Ser Val Ile Gly Ile Asn Xaa Ser Val Leu Ser Xaa Xaa Ala Ser 
            180                 185                 190         


Ser Ser Met Gly Gln Xaa Lys Ser Xaa Ser Ser Gly Gly Gly Asn Arg 
        195                 200                 205             


Lys Cys Asn Gln Glu Gln Ser Lys Asn Gln Pro Leu Asp Ala Arg Val 
    210                 215                 220                 


Asp Lys Ile Lys Asp Lys Lys Pro Arg Lys Lys Ala Met Glu Ser Ser 
225                 230                 235                 240 


Ser Asn Ser Asp Ser Asp Ser Gly Xaa Ser Ser Asp Xaa Ser Ser Glu 
                245                 250                 255     


Gly Ile Ser Ser Ser Asp Ser Asp Asp Leu Glu Glu Asp Glu Glu Glu 
            260                 265                 270         


Glu Asp Gln Ser Ile Glu Glu Ser Glu Asp Asp Asp Ser Asp Ser Glu 
        275                 280                 285             


Ser Glu Ala Gln His Lys Ser Asn Asn Gln Val Leu Leu His Gly Ile 
    290                 295                 300                 


Ser Asp Pro Lys Ala Asp Gly Gln Lys Ala Xaa Glu Lys Ala Gln Glu 
305                 310                 315                 320 


Lys Arg Ile His Gln Pro Leu Pro Leu Ala Ser Glu Ser Gln Xaa His 
                325                 330                 335     


Ser Phe Gln Ser Gln Gln Lys Gln Pro Gln Val Leu Ser Gln Gln Leu 
            340                 345                 350         


Pro Phe Ile Phe Gln Ser Ser Gln Ala Lys Glu Glu Ser Val Asn Lys 
        355                 360                 365             


His Xaa Ser Val Ile Gln Ser Xaa Gly Leu Val Ser Asn Val Lys Pro 
    370                 375                 380                 


Leu Ser Leu Val Asn Gln Ala Lys Lys Glu Xaa Tyr Met Lys Leu Ile 
385                 390                 395                 400 


Val Pro Ser Pro Asp Val Leu Lys Ala Gly Asn Lys Asn Xaa Ser Glu 
                405                 410                 415     


Glu Ser Ser Leu Leu Xaa Ser Glu Leu Arg Ser Lys Arg Glu Gln Tyr 
            420                 425                 430         


Lys Gln Ala Phe Pro Ser Gln Leu Lys Lys Gln Glu Ser Ser Lys Ser 
        435                 440                 445             


Leu Lys Lys Val Ile Ala Ala Leu Ser Asn Pro Lys Ala Xaa Ser Ser 
    450                 455                 460                 


Ser Pro Ala His Pro Lys Gln Xaa Leu Glu Asn Asn His Pro Asn Pro 
465                 470                 475                 480 


Phe Leu Xaa Asn Ala Leu Leu Gly Asn His Gln Pro Asn Gly Val Ile 
                485                 490                 495     


Gln Ser Val Ile Gln Glu Ala Pro Leu Ala Leu Xaa Xaa Lys Xaa Lys 
            500                 505                 510         


Met Gln Ser Lys Ile Asn Glu Asn Ile Ala Ala Ala Ser Ser Xaa Pro 
        515                 520                 525             


Phe Ser Ser Pro Val Asn Leu Ser Xaa Ser Gly Arg Arg Xaa Pro Gly 
    530                 535                 540                 


Asn Gln Xaa Pro Val Met Pro Ser Ala Ser Pro Ile Leu His Ser Gln 
545                 550                 555                 560 


Gly Lys Glu Lys Ala Val Ser Asn Asn Val Asn Pro Val Lys Xaa Gln 
                565                 570                 575     


His His Ser His Pro Ala Lys Ser Leu Val Glu Gln Phe Arg Gly Xaa 
            580                 585                 590         


Asp Ser Asp Ile Pro Ser Ser Lys Asp Ser Glu Asp Ser Asn Glu Asp 
        595                 600                 605             


Glu Glu Glu Asp Asp Glu Glu Glu Asp Glu Glu Asp Asp Glu Asp Asp 
    610                 615                 620                 


Glu Ser Asp Asp Ser Gln Ser Glu Ser Asp Ser Asn Ser Glu Ser Asp 
625                 630                 635                 640 


Xaa Glu Gly Ser Glu Glu Glu Asp Asp Asp Asp Lys Asp Gln Asp Glu 
                645                 650                 655     


Ser Asp Ser Asp Xaa Glu Gly Glu Lys Xaa Ser Met Lys Leu Asn Lys 
            660                 665                 670         


Xaa Xaa Ser Ser Val Lys Ser Pro Ser Met Ser Leu Xaa Gly His Ser 
        675                 680                 685             


Xaa Pro Arg Asn Leu His Ile Ala Lys Ala Pro Gly Ser Ala Pro Ala 
    690                 695                 700                 


Ala Leu Cys Ser Glu Ser Gln Ser Pro Ala Phe Leu Gly Xaa Ser Ser 
705                 710                 715                 720 


Ser Xaa Leu Xaa Ser Ser Pro His Ser Gly Xaa Ser Lys Arg Arg Arg 
                725                 730                 735     


Val Xaa Asp Glu Arg Glu Leu Arg Ile Pro Leu Glu Tyr Gly Trp Gln 
            740                 745                 750         


Arg Glu Xaa Arg Ile Arg Asn Phe Gly Gly Arg Leu Gln Gly Glu Val 
        755                 760                 765             


Ala Tyr Tyr Ala Pro Cys Gly Lys Lys Leu Arg Gln Tyr Pro Glu Val 
    770                 775                 780                 


Ile Lys Gly Met Gln Trp Cys Leu Leu Lys Glu Glu Asp Val Ile Pro 
785                 790                 795                 800 


Arg Ile Arg Ala Met Glu Gly Arg Arg Gly Arg Pro Pro Asn Pro Asp 
                805                 810                 815     


Arg Gln Arg Ala Arg Glu Glu Ser Arg Met Arg Arg Arg Lys Gly Arg 
            820                 825                 830         


Pro Pro Asn Val Gly Asn Ala Glu Phe Leu Asp Asn Ala Asp Ala Lys 
        835                 840                 845             


Leu Leu Arg Lys Leu Gln Ala Gln Glu Ile Ala Arg Gln Ala Ala Gln 
    850                 855                 860                 


Ile Lys Leu Leu Arg Lys Leu Gln Lys Gln Glu Gln Ala Arg Val Ala 
865                 870                 875                 880 


Lys Glu Ala Lys Lys Gln Gln Ala Ile Met Ala Ala Glu Glu Lys Arg 
                885                 890                 895     


Lys Gln Lys Glu Gln Ile Lys Ile Met Lys Gln Gln Glu Lys Ile Lys 
            900                 905                 910         


Arg Ile Gln Gln Ile Arg Met Glu Lys Glu Leu Arg Ala Gln Gln Ile 
        915                 920                 925             


Leu Glu Ala Lys Lys Lys Lys Lys Glu Glu Ala Ala Asn Ala Lys Leu 
    930                 935                 940                 


Leu Glu Ala Glu Lys Arg Ile Lys Glu Lys Glu Met Arg Arg Gln Gln 
945                 950                 955                 960 


Ala Val Leu Leu Lys His Gln Glu Arg Glu Arg Arg Arg Gln His Met 
                965                 970                 975     


Met Leu Met Lys Ala Met Glu Ala Arg Lys Lys Ala Glu Glu Lys Glu 
            980                 985                 990         


Arg Leu Lys Gln Glu Lys Arg Asp  Glu Lys Arg Leu Asn  Lys Glu Arg 
        995                 1000                 1005             


Lys Leu  Glu Gln Arg Arg Leu  Glu Leu Glu Met Ala  Lys Glu Leu 
    1010                 1015                 1020             


Lys Lys  Pro Asn Glu Asp Met  Cys Leu Ala Asp Gln  Lys Pro Leu 
    1025                 1030                 1035             


Pro Glu  Leu Pro Arg Ile Pro  Gly Leu Val Leu Ser  Gly Ser Xaa 
    1040                 1045                 1050             


Phe Ser  Asp Cys Leu Met Val  Val Gln Phe Leu Arg  Asn Phe Gly 
    1055                 1060                 1065             


Lys Val  Leu Gly Phe Asp Val  Asn Ile Asp Val Pro  Asn Leu Ser 
    1070                 1075                 1080             


Val Leu  Gln Glu Gly Leu Leu  Asn Ile Gly Asp Ser  Met Gly Glu 
    1085                 1090                 1095             


Val Gln  Asp Leu Leu Val Arg  Leu Leu Ser Ala Ala  Val Cys Asp 
    1100                 1105                 1110             


Pro Gly  Leu Ile Xaa Gly Tyr  Lys Ala Lys Xaa Ala  Leu Gly Glu 
    1115                 1120                 1125             


His Leu  Leu Asn Val Gly Val  Asn Arg Asp Asn Val  Ser Glu Ile 
    1130                 1135                 1140             


Leu Gln  Ile Phe Met Glu Ala  His Cys Gly Gln Xaa  Glu Leu Xaa 
    1145                 1150                 1155             


Glu Ser  Leu Lys Xaa Lys Ala  Phe Gln Ala His Xaa  Pro Ala Gln 
    1160                 1165                 1170             


Lys Ala  Ser Val Leu Ala Phe  Leu Ile Asn Glu Leu  Ala Cys Ser 
    1175                 1180                 1185             


Lys Ser  Val Val Ser Glu Ile  Asp Lys Asn Ile Asp  Tyr Met Ser 
    1190                 1195                 1200             


Asn Leu  Arg Arg Asp Lys Trp  Val Val Glu Gly Lys  Leu Arg Lys 
    1205                 1210                 1215             


Leu Arg  Ile Ile His Ala Lys  Lys Xaa Gly Lys Arg  Asp Xaa Ser 
    1220                 1225                 1230             


Gly Gly  Ile Asp Leu Gly Glu  Glu Gln His Pro Leu  Gly Xaa Pro 
    1235                 1240                 1245             


Xaa Pro  Gly Arg Lys Arg Arg  Arg Lys Gly Gly Asp  Ser Asp Tyr 
    1250                 1255                 1260             


Asp Asp  Asp Asp Asp Asp Asp  Ser Asp Asp Gln Gly  Asp Glu Asp 
    1265                 1270                 1275             


Asp Glu  Asp Glu Glu Asp Lys  Glu Asp Lys Lys Gly  Lys Lys Xaa 
    1280                 1285                 1290             


Asp Ile  Cys Glu Asp Glu Asp  Glu Gly Asp Gln Ala  Ala Ser Val 
    1295                 1300                 1305             


Glu Glu  Leu Glu Lys Gln Ile  Glu Lys Leu Ser Lys  Gln Gln Ser 
    1310                 1315                 1320             


Gln Tyr  Arg Arg Lys Leu Phe  Asp Ala Ser His Ser  Leu Arg Ser 
    1325                 1330                 1335             


Val Met  Phe Gly Gln Asp Arg  Tyr Arg Arg Arg Tyr  Trp Ile Leu 
    1340                 1345                 1350             


Pro Gln  Cys Gly Gly Ile Phe  Val Glu Gly Met Glu  Ser Gly Glu 
    1355                 1360                 1365             


Gly Leu  Glu Glu Ile Ala Lys  Glu Arg Glu Lys Leu  Lys Lys Ala 
    1370                 1375                 1380             


Glu Ser  Val Gln Ile Lys Glu  Glu Met Phe Glu Xaa  Ser Gly Asp 
    1385                 1390                 1395             


Ser Leu  Asn Cys Ser Asn Xaa  Asp His Cys Glu Gln  Lys Glu Asp 
    1400                 1405                 1410             


Leu Lys  Glu Lys Asp Asn Xaa  Asn Leu Phe Leu Gln  Lys Pro Gly 
    1415                 1420                 1425             


Ser Phe  Ser Lys Leu Ser Lys  Leu Leu Glu Val Ala  Lys Met Pro 
    1430                 1435                 1440             


Pro Glu  Ser Glu Val Met Xaa  Pro Lys Pro Asn Ala  Gly Ala Asn 
    1445                 1450                 1455             


Gly Cys  Xaa Leu Ser Tyr Gln  Asn Ser Gly Lys His  Ser Leu Gly 
    1460                 1465                 1470             


Ser Val  Gln Ser Xaa Ala Xaa  Gln Ser Asn Val Glu  Lys Ala Asp 
    1475                 1480                 1485             


Ser Asn  Asn Leu Phe Asn Xaa  Gly Ser Ser Gly Pro  Gly Lys Phe 
    1490                 1495                 1500             


Tyr Ser  Pro Leu Pro Asn Asp  Gln Leu Leu Lys Xaa  Leu Xaa Glu 
    1505                 1510                 1515             


Lys Asn  Arg Gln Trp Phe Ser  Leu Leu Pro Arg Xaa  Pro Cys Asp 
    1520                 1525                 1530             


Asp Xaa  Ser Leu Xaa His Ala  Asp Met Ser Xaa Ala  Ser Leu Val 
    1535                 1540                 1545             


Xaa Pro  Gln Ser Gln Pro Pro  Ser Lys Ser Pro Ser  Pro Xaa Pro 
    1550                 1555                 1560             


Ala Pro  Leu Gly Ser Ser Ala  Gln Asn Pro Val Gly  Leu Asn Pro 
    1565                 1570                 1575             


Phe Ala  Leu Ser Pro Leu Gln  Val Lys Gly Gly Val  Ser Met Met 
    1580                 1585                 1590             


Gly Leu  Gln Phe Cys Gly Trp  Pro Xaa Gly Val Val  Xaa Ser Asn 
    1595                 1600                 1605             


Ile Pro  Phe Xaa Ser Ser Val  Pro Ser Leu Gly Ser  Gly Leu Gly 
    1610                 1615                 1620             


Leu Ser  Glu Gly Asn Gly Asn  Ser Phe Leu Xaa Ser  Asn Val Ala 
    1625                 1630                 1635             


Ser Ser  Lys Ser Glu Ser Pro  Val Pro Gln Asn Glu  Lys Ala Xaa 
    1640                 1645                 1650             


Ser Ala  Gln Pro Ala Ala Val  Glu Val Ala Lys Pro  Val Asp Phe 
    1655                 1660                 1665             


Pro Ser  Pro Lys Pro Ile Pro  Glu Glu Met Gln Phe  Gly Trp Trp 
    1670                 1675                 1680             


Arg Ile  Ile Asp Pro Glu Asp  Leu Lys Ala Leu Leu  Lys Val Leu 
    1685                 1690                 1695             


His Leu  Arg Gly Ile Arg Glu  Lys Ala Leu Gln Lys  Gln Ile Gln 
    1700                 1705                 1710             


Lys His  Leu Asp Tyr Ile Xaa  Gln Ala Cys Leu Lys  Asn Lys Asp 
    1715                 1720                 1725             


Val Ala  Ile Ile Glu Leu Asn  Glu Asn Glu Glu Asn  Gln Val Xaa 
    1730                 1735                 1740             


Arg Asp  Ile Val Glu Asn Trp  Ser Val Glu Glu Gln  Ala Met Glu 
    1745                 1750                 1755             


Met Asp  Leu Ser Val Leu Gln  Gln Val Glu Asp Leu  Glu Arg Arg 
    1760                 1765                 1770             


Val Ala  Ser Ala Ser Leu Gln  Val Lys Gly Trp Met  Cys Pro Glu 
    1775                 1780                 1785             


Pro Ala  Ser Glu Arg Glu Asp  Leu Val Tyr Phe Glu  His Lys Ser 
    1790                 1795                 1800             


Phe Xaa  Lys Leu Cys Lys Glu  His Asp Gly Glu Phe  Xaa Gly Glu 
    1805                 1810                 1815             


Asp Glu  Ser Ser Ala His Ala  Leu Glu Arg Lys Ser  Asp Asn Pro 
    1820                 1825                 1830             


Leu Asp  Ile Ala Val Xaa Arg  Leu Ala Asp Leu Glu  Arg Asn Ile 
    1835                 1840                 1845             


Glu Arg  Arg Ile Glu Glu Asp  Ile Ala Pro Gly Leu  Arg Val Trp 
    1850                 1855                 1860             


Arg Arg  Ala Leu Ser Glu Ala  Arg Ser Ala Ala Gln  Val Ala Leu 
    1865                 1870                 1875             


Cys Ile  Gln Gln Leu Gln Lys  Ser Ile Ala Trp Glu  Lys Ser Ile 
    1880                 1885                 1890             


Met Lys  Val Tyr Cys Gln Ile  Cys Arg Lys Gly Asp  Asn Glu Glu 
    1895                 1900                 1905             


Leu Leu  Leu Leu Cys Asp Gly  Cys Asp Lys Gly Cys  His Xaa Tyr 
    1910                 1915                 1920             


Cys His  Arg Pro Lys Ile Xaa  Xaa Ile Pro Asp Gly  Asp Trp Phe 
    1925                 1930                 1935             


Cys Pro  Ala Cys Ile Ala Lys  Ala Ser Gly Gln Xaa  Leu Lys Ile 
    1940                 1945                 1950             


Lys Lys  Leu His Val Lys Gly  Lys Lys Xaa Asn Glu  Ser Lys Lys 
    1955                 1960                 1965             


Gly Lys  Lys Val Xaa Leu Xaa  Gly Asp Xaa Glu Asp  Glu Asp Ser 
    1970                 1975                 1980             


Ala Ser  Xaa Ser Ser Ser Leu  Lys Arg Gly Asn Lys  Asp Leu Lys 
    1985                 1990                 1995             


Lys Arg  Lys Met Glu Glu Asn  Xaa Ser Ile Asn Leu  Ser Lys Gln 
    2000                 2005                 2010             


Glu Ser  Phe Xaa Ser Val Lys  Lys Pro Lys Arg Asp  Asp Ser Lys 
    2015                 2020                 2025             


Asp Leu  Ala Leu Cys Ser Met  Ile Leu Xaa Glu Met  Glu Xaa His 
    2030                 2035                 2040             


Glu Asp  Ala Trp Pro Phe Leu  Leu Pro Val Asn Leu  Lys Leu Val 
    2045                 2050                 2055             


Pro Gly  Tyr Lys Lys Val Ile  Lys Lys Pro Met Asp  Phe Ser Xaa 
    2060                 2065                 2070             


Ile Arg  Glu Lys Leu Ser Ser  Gly Gln Tyr Pro Asn  Leu Glu Xaa 
    2075                 2080                 2085             


Phe Ala  Leu Asp Val Arg Leu  Val Phe Asp Asn Cys  Glu Xaa Phe 
    2090                 2095                 2100             


Asn Glu  Asp Asp Ser Asp Ile  Gly Arg Ala Gly His  Asn Met Arg 
    2105                 2110                 2115             


Lys Tyr  Phe Glu Lys Lys Trp  Xaa Asp Xaa Phe Lys  Val Ser 
    2120                 2125                 2130         


<210> 3968
<211> 143
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 3968
Met Glu Ser Gly Glu Arg Leu Pro Ser Ser Ala Ala Ser Ser Xaa Xaa 
1               5                   10                  15      


Pro Xaa Ser Ser Ser Xaa Pro Ser Val Ala Ser Val Val Ser Lys Gly 
            20                  25                  30          


Gly Leu Ser Xaa Gly Val Ala Ser Leu Ser Ser Xaa Ile Asn Pro Cys 
        35                  40                  45              


Gly His Leu Phe Arg Xaa Ala Gly Asp Gln Pro Phe Asn Leu Ser Xaa 
    50                  55                  60                  


Val Ser Ser Ala Phe Pro Met Val Ser His Pro Val Phe Gly Leu His 
65                  70                  75                  80  


Ser Ala Ser Ser Gly His Ser Glu Phe Gly Gly Leu Gly Xaa Leu Gly 
                85                  90                  95      


Xaa Pro Xaa Ala Leu Ala Ala His Pro Gln Leu Ala Ser Phe Pro Gly 
            100                 105                 110         


Ala Glu Trp Trp Arg Xaa Xaa Asp Ala His Xaa Arg Xaa Gly Ala Xaa 
        115                 120                 125             


Phe Phe Pro Pro Leu Leu Gly Ile Pro Pro Leu Phe Ala Pro Pro 
    130                 135                 140             


<210> 3969
<211> 2168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1191)..(1191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1206)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1268)..(1268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1431)..(1431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1456)..(1456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1486)..(1486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1497)..(1497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1514)..(1514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1516)..(1516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1531)..(1531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1551)..(1551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1553)..(1553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1566)..(1566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1571)..(1571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1580)..(1580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1585)..(1585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1598)..(1598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1638)..(1638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1642)..(1642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1648)..(1648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1670)..(1670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1689)..(1689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1756)..(1756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1779)..(1779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1841)..(1841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1852)..(1852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1875)..(1875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1958)..(1958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1966)..(1967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1986)..(1986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1999)..(1999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2009)..(2009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2011)..(2011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2014)..(2014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2022)..(2022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2042)..(2042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2053)..(2053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2074)..(2074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2078)..(2078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2109)..(2109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2124)..(2124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2138)..(2138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2162)..(2162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2164)..(2164)
<223> Selenocysteine

<400> 3969
Met Glu Ser Gly Glu Arg Leu Pro Ser Ser Ala Ala Ser Ser Xaa Xaa 
1               5                   10                  15      


Pro Xaa Ser Ser Ser Xaa Pro Ser Val Ala Ser Val Val Ser Lys Gly 
            20                  25                  30          


Gly Leu Ser Xaa Gly Val Ala Ser Leu Ser Ser Xaa Ile Asn Pro Cys 
        35                  40                  45              


Gly His Leu Phe Arg Xaa Ala Gly Asp Gln Pro Phe Asn Leu Ser Xaa 
    50                  55                  60                  


Val Ser Ser Ala Phe Pro Met Val Ser His Pro Val Phe Gly Leu His 
65                  70                  75                  80  


Ser Ala Ser Ser Gly His Ser Glu Phe Gly Gly Leu Gly Xaa Leu Gly 
                85                  90                  95      


Xaa Pro Xaa Ala Leu Ala Ala His Pro Gln Leu Ala Ser Phe Pro Gly 
            100                 105                 110         


Ala Glu Trp Trp Arg Xaa Xaa Asp Ala His Xaa Arg Xaa Gly Ala Xaa 
        115                 120                 125             


Phe Phe Pro Pro Leu Leu Gly Ile Pro Pro Leu Phe Ala Pro Pro Ala 
    130                 135                 140                 


Gln Asn His Asp Ser Ser Ser Phe His Ser Arg Xaa Ser Gly Lys Ser 
145                 150                 155                 160 


Asn Arg Asn Gly Pro Glu Lys Gly Val Asn Gly Ser Ile Asn Gly Ser 
                165                 170                 175     


Asn Xaa Ser Ser Val Ile Gly Ile Asn Xaa Ser Val Leu Ser Xaa Xaa 
            180                 185                 190         


Ala Ser Ser Ser Met Gly Gln Xaa Lys Ser Xaa Ser Ser Gly Gly Gly 
        195                 200                 205             


Asn Arg Lys Cys Asn Gln Glu Gln Ser Lys Asn Gln Pro Leu Asp Ala 
    210                 215                 220                 


Arg Val Asp Lys Ile Lys Asp Lys Lys Pro Arg Lys Lys Ala Met Glu 
225                 230                 235                 240 


Ser Ser Ser Asn Ser Asp Ser Asp Ser Gly Xaa Ser Ser Asp Xaa Ser 
                245                 250                 255     


Ser Glu Gly Ile Ser Ser Ser Asp Ser Asp Asp Leu Glu Glu Asp Glu 
            260                 265                 270         


Glu Glu Glu Asp Gln Ser Ile Glu Glu Ser Glu Asp Asp Asp Ser Asp 
        275                 280                 285             


Ser Glu Ser Glu Ala Gln His Lys Ser Asn Asn Gln Val Leu Leu His 
    290                 295                 300                 


Gly Ile Ser Asp Pro Lys Ala Asp Gly Gln Lys Ala Xaa Glu Lys Ala 
305                 310                 315                 320 


Gln Glu Lys Arg Ile His Gln Pro Leu Pro Leu Ala Ser Glu Ser Gln 
                325                 330                 335     


Xaa His Ser Phe Gln Ser Gln Gln Lys Gln Pro Gln Val Leu Ser Gln 
            340                 345                 350         


Gln Leu Pro Phe Ile Phe Gln Ser Ser Gln Ala Lys Glu Glu Ser Val 
        355                 360                 365             


Asn Lys His Xaa Ser Val Ile Gln Ser Xaa Gly Leu Val Ser Asn Val 
    370                 375                 380                 


Lys Pro Leu Ser Leu Val Asn Gln Ala Lys Lys Glu Xaa Tyr Met Lys 
385                 390                 395                 400 


Leu Ile Val Pro Ser Pro Asp Val Leu Lys Ala Gly Asn Lys Asn Xaa 
                405                 410                 415     


Ser Glu Glu Ser Ser Leu Leu Xaa Ser Glu Leu Arg Ser Lys Arg Glu 
            420                 425                 430         


Gln Tyr Lys Gln Ala Phe Pro Ser Gln Leu Lys Lys Gln Glu Ser Ser 
        435                 440                 445             


Lys Ser Leu Lys Lys Val Ile Ala Ala Leu Ser Asn Pro Lys Ala Xaa 
    450                 455                 460                 


Ser Ser Ser Pro Ala His Pro Lys Gln Xaa Leu Glu Asn Asn His Pro 
465                 470                 475                 480 


Asn Pro Phe Leu Xaa Asn Ala Leu Leu Gly Asn His Gln Pro Asn Gly 
                485                 490                 495     


Val Ile Gln Ser Val Ile Gln Glu Ala Pro Leu Ala Leu Xaa Xaa Lys 
            500                 505                 510         


Xaa Lys Met Gln Ser Lys Ile Asn Glu Asn Ile Ala Ala Ala Ser Ser 
        515                 520                 525             


Xaa Pro Phe Ser Ser Pro Val Asn Leu Ser Xaa Ser Gly Arg Arg Xaa 
    530                 535                 540                 


Pro Gly Asn Gln Xaa Pro Val Met Pro Ser Ala Ser Pro Ile Leu His 
545                 550                 555                 560 


Ser Gln Gly Lys Glu Lys Ala Val Ser Asn Asn Val Asn Pro Val Lys 
                565                 570                 575     


Xaa Gln His His Ser His Pro Ala Lys Ser Leu Val Glu Gln Phe Arg 
            580                 585                 590         


Gly Xaa Asp Ser Asp Ile Pro Ser Ser Lys Asp Ser Glu Asp Ser Asn 
        595                 600                 605             


Glu Asp Glu Glu Glu Asp Asp Glu Glu Glu Asp Glu Glu Asp Asp Glu 
    610                 615                 620                 


Asp Asp Glu Ser Asp Asp Ser Gln Ser Glu Ser Asp Ser Asn Ser Glu 
625                 630                 635                 640 


Ser Asp Xaa Glu Gly Ser Glu Glu Glu Asp Asp Asp Asp Lys Asp Gln 
                645                 650                 655     


Asp Glu Ser Asp Ser Asp Xaa Glu Gly Glu Lys Xaa Ser Met Lys Leu 
            660                 665                 670         


Asn Lys Xaa Xaa Ser Ser Val Lys Ser Pro Ser Met Ser Leu Xaa Gly 
        675                 680                 685             


His Ser Xaa Pro Arg Asn Leu His Ile Ala Lys Ala Pro Gly Ser Ala 
    690                 695                 700                 


Pro Ala Ala Leu Cys Ser Glu Ser Gln Ser Pro Ala Phe Leu Gly Xaa 
705                 710                 715                 720 


Ser Ser Ser Xaa Leu Xaa Ser Ser Pro His Ser Gly Xaa Ser Lys Arg 
                725                 730                 735     


Arg Arg Val Xaa Asp Glu Arg Glu Leu Arg Ile Pro Leu Glu Tyr Gly 
            740                 745                 750         


Trp Gln Arg Glu Xaa Arg Ile Arg Asn Phe Gly Gly Arg Leu Gln Gly 
        755                 760                 765             


Glu Val Ala Tyr Tyr Ala Pro Cys Gly Lys Lys Leu Arg Gln Tyr Pro 
    770                 775                 780                 


Glu Val Ile Lys Tyr Leu Ser Arg Asn Gly Ile Met Asp Ile Ser Arg 
785                 790                 795                 800 


Asp Asn Phe Ser Phe Ser Ala Lys Ile Arg Val Gly Asp Phe Tyr Glu 
                805                 810                 815     


Ala Arg Asp Gly Pro Gln Gly Met Gln Trp Cys Leu Leu Lys Glu Glu 
            820                 825                 830         


Asp Val Ile Pro Arg Ile Arg Ala Met Glu Gly Arg Arg Gly Arg Pro 
        835                 840                 845             


Pro Asn Pro Asp Arg Gln Arg Ala Arg Glu Glu Ser Arg Met Arg Arg 
    850                 855                 860                 


Arg Lys Gly Arg Pro Pro Asn Val Gly Asn Ala Glu Phe Leu Asp Asn 
865                 870                 875                 880 


Ala Asp Ala Lys Leu Leu Arg Lys Leu Gln Ala Gln Glu Ile Ala Arg 
                885                 890                 895     


Gln Ala Ala Gln Ile Lys Leu Leu Arg Lys Leu Gln Lys Gln Glu Gln 
            900                 905                 910         


Ala Arg Val Ala Lys Glu Ala Lys Lys Gln Gln Ala Ile Met Ala Ala 
        915                 920                 925             


Glu Glu Lys Arg Lys Gln Lys Glu Gln Ile Lys Ile Met Lys Gln Gln 
    930                 935                 940                 


Glu Lys Ile Lys Arg Ile Gln Gln Ile Arg Met Glu Lys Glu Leu Arg 
945                 950                 955                 960 


Ala Gln Gln Ile Leu Glu Ala Lys Lys Lys Lys Lys Glu Glu Ala Ala 
                965                 970                 975     


Asn Ala Lys Leu Leu Glu Ala Glu Lys Arg Ile Lys Glu Lys Glu Met 
            980                 985                 990         


Arg Arg Gln Gln Ala Val Leu Leu  Lys His Gln Glu Arg  Glu Arg Arg 
        995                 1000                 1005             


Arg Gln  His Met Met Leu Met  Lys Ala Met Glu Ala  Arg Lys Lys 
    1010                 1015                 1020             


Ala Glu  Glu Lys Glu Arg Leu  Lys Gln Glu Lys Arg  Asp Glu Lys 
    1025                 1030                 1035             


Arg Leu  Asn Lys Glu Arg Lys  Leu Glu Gln Arg Arg  Leu Glu Leu 
    1040                 1045                 1050             


Glu Met  Ala Lys Glu Leu Lys  Lys Pro Asn Glu Asp  Met Cys Leu 
    1055                 1060                 1065             


Ala Asp  Gln Lys Pro Leu Pro  Glu Leu Pro Arg Ile  Pro Gly Leu 
    1070                 1075                 1080             


Val Leu  Ser Gly Ser Xaa Phe  Ser Asp Cys Leu Met  Val Val Gln 
    1085                 1090                 1095             


Phe Leu  Arg Asn Phe Gly Lys  Val Leu Gly Phe Asp  Val Asn Ile 
    1100                 1105                 1110             


Asp Val  Pro Asn Leu Ser Val  Leu Gln Glu Gly Leu  Leu Asn Ile 
    1115                 1120                 1125             


Gly Asp  Ser Met Gly Glu Val  Gln Asp Leu Leu Val  Arg Leu Leu 
    1130                 1135                 1140             


Ser Ala  Ala Val Cys Asp Pro  Gly Leu Ile Xaa Gly  Tyr Lys Ala 
    1145                 1150                 1155             


Lys Xaa  Ala Leu Gly Glu His  Leu Leu Asn Val Gly  Val Asn Arg 
    1160                 1165                 1170             


Asp Asn  Val Ser Glu Ile Leu  Gln Ile Phe Met Glu  Ala His Cys 
    1175                 1180                 1185             


Gly Gln  Xaa Glu Leu Xaa Glu  Ser Leu Lys Xaa Lys  Ala Phe Gln 
    1190                 1195                 1200             


Ala His  Xaa Pro Ala Gln Lys  Ala Ser Val Leu Ala  Phe Leu Ile 
    1205                 1210                 1215             


Asn Glu  Leu Ala Cys Ser Lys  Ser Val Val Ser Glu  Ile Asp Lys 
    1220                 1225                 1230             


Asn Ile  Asp Tyr Met Ser Asn  Leu Arg Arg Asp Lys  Trp Val Val 
    1235                 1240                 1245             


Glu Gly  Lys Leu Arg Lys Leu  Arg Ile Ile His Ala  Lys Lys Xaa 
    1250                 1255                 1260             


Gly Lys  Arg Asp Xaa Ser Gly  Gly Ile Asp Leu Gly  Glu Glu Gln 
    1265                 1270                 1275             


His Pro  Leu Gly Xaa Pro Xaa  Pro Gly Arg Lys Arg  Arg Arg Lys 
    1280                 1285                 1290             


Gly Gly  Asp Ser Asp Tyr Asp  Asp Asp Asp Asp Asp  Asp Ser Asp 
    1295                 1300                 1305             


Asp Gln  Gly Asp Glu Asp Asp  Glu Asp Glu Glu Asp  Lys Glu Asp 
    1310                 1315                 1320             


Lys Lys  Gly Lys Lys Xaa Asp  Ile Cys Glu Asp Glu  Asp Glu Gly 
    1325                 1330                 1335             


Asp Gln  Ala Ala Ser Val Glu  Glu Leu Glu Lys Gln  Ile Glu Lys 
    1340                 1345                 1350             


Leu Ser  Lys Gln Gln Ser Gln  Tyr Arg Arg Lys Leu  Phe Asp Ala 
    1355                 1360                 1365             


Ser His  Ser Leu Arg Ser Val  Met Phe Gly Gln Asp  Arg Tyr Arg 
    1370                 1375                 1380             


Arg Arg  Tyr Trp Ile Leu Pro  Gln Cys Gly Gly Ile  Phe Val Glu 
    1385                 1390                 1395             


Gly Met  Glu Ser Gly Glu Gly  Leu Glu Glu Ile Ala  Lys Glu Arg 
    1400                 1405                 1410             


Glu Lys  Leu Lys Lys Ala Glu  Ser Val Gln Ile Lys  Glu Glu Met 
    1415                 1420                 1425             


Phe Glu  Xaa Ser Gly Asp Ser  Leu Asn Cys Ser Asn  Xaa Asp His 
    1430                 1435                 1440             


Cys Glu  Gln Lys Glu Asp Leu  Lys Glu Lys Asp Asn  Xaa Asn Leu 
    1445                 1450                 1455             


Phe Leu  Gln Lys Pro Gly Ser  Phe Ser Lys Leu Ser  Lys Leu Leu 
    1460                 1465                 1470             


Glu Val  Ala Lys Met Pro Pro  Glu Ser Glu Val Met  Xaa Pro Lys 
    1475                 1480                 1485             


Pro Asn  Ala Gly Ala Asn Gly  Cys Xaa Leu Ser Tyr  Gln Asn Ser 
    1490                 1495                 1500             


Gly Lys  His Ser Leu Gly Ser  Val Gln Ser Xaa Ala  Xaa Gln Ser 
    1505                 1510                 1515             


Asn Val  Glu Lys Ala Asp Ser  Asn Asn Leu Phe Asn  Xaa Gly Ser 
    1520                 1525                 1530             


Ser Gly  Pro Gly Lys Phe Tyr  Ser Pro Leu Pro Asn  Asp Gln Leu 
    1535                 1540                 1545             


Leu Lys  Xaa Leu Xaa Glu Lys  Asn Arg Gln Trp Phe  Ser Leu Leu 
    1550                 1555                 1560             


Pro Arg  Xaa Pro Cys Asp Asp  Xaa Ser Leu Xaa His  Ala Asp Met 
    1565                 1570                 1575             


Ser Xaa  Ala Ser Leu Val Xaa  Pro Gln Ser Gln Pro  Pro Ser Lys 
    1580                 1585                 1590             


Ser Pro  Ser Pro Xaa Pro Ala  Pro Leu Gly Ser Ser  Ala Gln Asn 
    1595                 1600                 1605             


Pro Val  Gly Leu Asn Pro Phe  Ala Leu Ser Pro Leu  Gln Val Lys 
    1610                 1615                 1620             


Gly Gly  Val Ser Met Met Gly  Leu Gln Phe Cys Gly  Trp Pro Xaa 
    1625                 1630                 1635             


Gly Val  Val Xaa Ser Asn Ile  Pro Phe Xaa Ser Ser  Val Pro Ser 
    1640                 1645                 1650             


Leu Gly  Ser Gly Leu Gly Leu  Ser Glu Gly Asn Gly  Asn Ser Phe 
    1655                 1660                 1665             


Leu Xaa  Ser Asn Val Ala Ser  Ser Lys Ser Glu Ser  Pro Val Pro 
    1670                 1675                 1680             


Gln Asn  Glu Lys Ala Xaa Ser  Ala Gln Pro Ala Ala  Val Glu Val 
    1685                 1690                 1695             


Ala Lys  Pro Val Asp Phe Pro  Ser Pro Lys Pro Ile  Pro Glu Glu 
    1700                 1705                 1710             


Met Gln  Phe Gly Trp Trp Arg  Ile Ile Asp Pro Glu  Asp Leu Lys 
    1715                 1720                 1725             


Ala Leu  Leu Lys Val Leu His  Leu Arg Gly Ile Arg  Glu Lys Ala 
    1730                 1735                 1740             


Leu Gln  Lys Gln Ile Gln Lys  His Leu Asp Tyr Ile  Xaa Gln Ala 
    1745                 1750                 1755             


Cys Leu  Lys Asn Lys Asp Val  Ala Ile Ile Glu Leu  Asn Glu Asn 
    1760                 1765                 1770             


Glu Glu  Asn Gln Val Xaa Arg  Asp Ile Val Glu Asn  Trp Ser Val 
    1775                 1780                 1785             


Glu Glu  Gln Ala Met Glu Met  Asp Leu Ser Val Leu  Gln Gln Val 
    1790                 1795                 1800             


Glu Asp  Leu Glu Arg Arg Val  Ala Ser Ala Ser Leu  Gln Val Lys 
    1805                 1810                 1815             


Gly Trp  Met Cys Pro Glu Pro  Ala Ser Glu Arg Glu  Asp Leu Val 
    1820                 1825                 1830             


Tyr Phe  Glu His Lys Ser Phe  Xaa Lys Leu Cys Lys  Glu His Asp 
    1835                 1840                 1845             


Gly Glu  Phe Xaa Gly Glu Asp  Glu Ser Ser Ala His  Ala Leu Glu 
    1850                 1855                 1860             


Arg Lys  Ser Asp Asn Pro Leu  Asp Ile Ala Val Xaa  Arg Leu Ala 
    1865                 1870                 1875             


Asp Leu  Glu Arg Asn Ile Glu  Arg Arg Ile Glu Glu  Asp Ile Ala 
    1880                 1885                 1890             


Pro Gly  Leu Arg Val Trp Arg  Arg Ala Leu Ser Glu  Ala Arg Ser 
    1895                 1900                 1905             


Ala Ala  Gln Val Ala Leu Cys  Ile Gln Gln Leu Gln  Lys Ser Ile 
    1910                 1915                 1920             


Ala Trp  Glu Lys Ser Ile Met  Lys Val Tyr Cys Gln  Ile Cys Arg 
    1925                 1930                 1935             


Lys Gly  Asp Asn Glu Glu Leu  Leu Leu Leu Cys Asp  Gly Cys Asp 
    1940                 1945                 1950             


Lys Gly  Cys His Xaa Tyr Cys  His Arg Pro Lys Ile  Xaa Xaa Ile 
    1955                 1960                 1965             


Pro Asp  Gly Asp Trp Phe Cys  Pro Ala Cys Ile Ala  Lys Ala Ser 
    1970                 1975                 1980             


Gly Gln  Xaa Leu Lys Ile Lys  Lys Leu His Val Lys  Gly Lys Lys 
    1985                 1990                 1995             


Xaa Asn  Glu Ser Lys Lys Gly  Lys Lys Val Xaa Leu  Xaa Gly Asp 
    2000                 2005                 2010             


Xaa Glu  Asp Glu Asp Ser Ala  Ser Xaa Ser Ser Ser  Leu Lys Arg 
    2015                 2020                 2025             


Gly Asn  Lys Asp Leu Lys Lys  Arg Lys Met Glu Glu  Asn Xaa Ser 
    2030                 2035                 2040             


Ile Asn  Leu Ser Lys Gln Glu  Ser Phe Xaa Ser Val  Lys Lys Pro 
    2045                 2050                 2055             


Lys Arg  Asp Asp Ser Lys Asp  Leu Ala Leu Cys Ser  Met Ile Leu 
    2060                 2065                 2070             


Xaa Glu  Met Glu Xaa His Glu  Asp Ala Trp Pro Phe  Leu Leu Pro 
    2075                 2080                 2085             


Val Asn  Leu Lys Leu Val Pro  Gly Tyr Lys Lys Val  Ile Lys Lys 
    2090                 2095                 2100             


Pro Met  Asp Phe Ser Xaa Ile  Arg Glu Lys Leu Ser  Ser Gly Gln 
    2105                 2110                 2115             


Tyr Pro  Asn Leu Glu Xaa Phe  Ala Leu Asp Val Arg  Leu Val Phe 
    2120                 2125                 2130             


Asp Asn  Cys Glu Xaa Phe Asn  Glu Asp Asp Ser Asp  Ile Gly Arg 
    2135                 2140                 2145             


Ala Gly  His Asn Met Arg Lys  Tyr Phe Glu Lys Lys  Trp Xaa Asp 
    2150                 2155                 2160             


Xaa Phe  Lys Val Ser 
    2165             


<210> 3970
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<400> 3970
Met Glu Ser Gly Glu Arg Leu Pro Ser Ser Ala Ala Ser Ser Xaa Xaa 
1               5                   10                  15      


Pro Xaa Ser Ser Ser Xaa Pro Ser Val Ala Ser Val Val Ser Lys Gly 
            20                  25                  30          


Gly Leu Ser Xaa Gly Val Ala Ser Leu Ser Ser Xaa Ile Asn Pro Cys 
        35                  40                  45              


Gly Val Asn Gly Ser Ile Asn Gly Ser Asn Xaa Ser Ser Val Ile Gly 
    50                  55                  60                  


Ile Asn Xaa Ser Val Leu Ser Xaa Xaa Ala Ser Ser Ser Met Gly Gln 
65                  70                  75                  80  


Xaa Lys Ser Xaa Ser Ser Gly Gly Gly Asn Arg Lys Cys Asn Gln 
                85                  90                  95  


<210> 3971
<211> 643
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<400> 3971
Met Gly Gln Xaa Lys Ser Xaa Ser Ser Gly Gly Gly Asn Arg Lys Cys 
1               5                   10                  15      


Asn Gln Glu Gln Ser Lys Asn Gln Pro Leu Asp Ala Arg Val Asp Lys 
            20                  25                  30          


Ile Lys Asp Lys Lys Pro Arg Lys Lys Ala Met Glu Ser Ser Ser Asn 
        35                  40                  45              


Ser Asp Ser Asp Ser Gly Xaa Ser Ser Asp Xaa Ser Ser Glu Gly Ile 
    50                  55                  60                  


Ser Ser Ser Asp Ser Asp Asp Leu Glu Glu Asp Glu Glu Glu Glu Asp 
65                  70                  75                  80  


Gln Ser Ile Glu Glu Ser Glu Asp Asp Asp Ser Asp Ser Glu Ser Glu 
                85                  90                  95      


Ala Gln His Lys Ser Asn Asn Gln Val Leu Leu His Gly Ile Ser Asp 
            100                 105                 110         


Pro Lys Ala Asp Gly Gln Lys Ala Xaa Glu Lys Ala Gln Glu Lys Arg 
        115                 120                 125             


Ile His Gln Pro Leu Pro Leu Ala Ser Glu Ser Gln Xaa His Ser Phe 
    130                 135                 140                 


Gln Ser Gln Gln Lys Gln Pro Gln Val Leu Ser Gln Gln Leu Pro Phe 
145                 150                 155                 160 


Ile Phe Gln Ser Ser Gln Ala Lys Glu Glu Ser Val Asn Lys His Xaa 
                165                 170                 175     


Ser Val Ile Gln Ser Xaa Gly Leu Val Ser Asn Val Lys Pro Leu Ser 
            180                 185                 190         


Leu Val Asn Gln Ala Lys Lys Glu Xaa Tyr Met Lys Leu Ile Val Pro 
        195                 200                 205             


Ser Pro Asp Val Leu Lys Ala Gly Asn Lys Asn Xaa Ser Glu Glu Ser 
    210                 215                 220                 


Ser Leu Leu Xaa Ser Glu Leu Arg Ser Lys Arg Glu Gln Tyr Lys Gln 
225                 230                 235                 240 


Ala Phe Pro Ser Gln Leu Lys Lys Gln Glu Ser Ser Lys Ser Leu Lys 
                245                 250                 255     


Lys Val Ile Ala Ala Leu Ser Asn Pro Lys Ala Xaa Ser Ser Ser Pro 
            260                 265                 270         


Ala His Pro Lys Gln Xaa Leu Glu Asn Asn His Pro Asn Pro Phe Leu 
        275                 280                 285             


Xaa Asn Ala Leu Leu Gly Asn His Gln Pro Asn Gly Val Ile Gln Ser 
    290                 295                 300                 


Val Ile Gln Glu Ala Pro Leu Ala Leu Xaa Xaa Lys Xaa Lys Met Gln 
305                 310                 315                 320 


Ser Lys Ile Asn Glu Asn Ile Ala Ala Ala Ser Ser Xaa Pro Phe Ser 
                325                 330                 335     


Ser Pro Val Asn Leu Ser Xaa Ser Gly Arg Arg Xaa Pro Gly Asn Gln 
            340                 345                 350         


Xaa Pro Val Met Pro Ser Ala Ser Pro Ile Leu His Ser Gln Gly Lys 
        355                 360                 365             


Glu Lys Ala Val Ser Asn Asn Val Asn Pro Val Lys Xaa Gln His His 
    370                 375                 380                 


Ser His Pro Ala Lys Ser Leu Val Glu Gln Phe Arg Gly Xaa Asp Ser 
385                 390                 395                 400 


Asp Ile Pro Ser Ser Lys Asp Ser Glu Asp Ser Asn Glu Asp Glu Glu 
                405                 410                 415     


Glu Asp Asp Glu Glu Glu Asp Glu Glu Asp Asp Glu Asp Asp Glu Ser 
            420                 425                 430         


Asp Asp Ser Gln Ser Gly Xaa Ser Lys Arg Arg Arg Val Xaa Asp Glu 
        435                 440                 445             


Arg Glu Leu Arg Ile Pro Leu Glu Tyr Gly Trp Gln Arg Glu Xaa Arg 
    450                 455                 460                 


Ile Arg Asn Phe Gly Gly Arg Leu Gln Gly Glu Val Ala Tyr Tyr Ala 
465                 470                 475                 480 


Pro Cys Gly Lys Lys Leu Arg Gln Tyr Pro Glu Val Ile Lys Tyr Leu 
                485                 490                 495     


Ser Arg Asn Gly Ile Met Asp Ile Ser Arg Asp Asn Phe Ser Phe Ser 
            500                 505                 510         


Ala Lys Ile Arg Val Gly Asp Phe Tyr Glu Ala Arg Asp Gly Pro Gln 
        515                 520                 525             


Gly Met Gln Trp Cys Leu Leu Lys Glu Glu Asp Val Ile Pro Arg Ile 
    530                 535                 540                 


Arg Ala Met Glu Gly Arg Arg Gly Arg Pro Pro Asn Pro Asp Arg Gln 
545                 550                 555                 560 


Arg Ala Arg Glu Glu Ser Arg Met Arg Arg Arg Lys Gly Arg Pro Pro 
                565                 570                 575     


Asn Val Gly Asn Ala Glu Phe Leu Asp Asn Ala Asp Ala Lys Leu Leu 
            580                 585                 590         


Arg Lys Leu Gln Ala Gln Glu Ile Ala Arg Gln Ala Ala Gln Ile Lys 
        595                 600                 605             


Leu Leu Arg Lys Leu Gln Lys Gln Glu Gln Ala Arg Val Ala Lys Glu 
    610                 615                 620                 


Ala Lys Lys Gln Gln Ala Ile Met Leu Leu Arg Arg Ser Gly Ser Lys 
625                 630                 635                 640 


Lys Asn Arg 
            


<210> 3972
<211> 179
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<400> 3972
Val Glu Asn Trp Ser Val Glu Glu Gln Ala Met Glu Met Asp Leu Ser 
1               5                   10                  15      


Val Leu Gln Gln Val Glu Asp Leu Glu Arg Arg Val Ala Ser Ala Ser 
            20                  25                  30          


Leu Gln Val Lys Gly Trp Met Cys Pro Glu Pro Ala Ser Glu Arg Glu 
        35                  40                  45              


Asp Leu Val Tyr Phe Glu His Lys Ser Phe Xaa Lys Leu Cys Lys Glu 
    50                  55                  60                  


His Asp Gly Glu Phe Xaa Gly Glu Asp Glu Ser Ser Ala His Ala Leu 
65                  70                  75                  80  


Glu Arg Lys Ser Asp Asn Pro Leu Asp Ile Ala Val Xaa Arg Leu Ala 
                85                  90                  95      


Asp Leu Glu Arg Asn Ile Glu Arg Arg Tyr Leu Lys Ser Pro Leu Ser 
            100                 105                 110         


Xaa Xaa Ile Gln Ile Lys Leu Asp Asn Val Gly Xaa Val Xaa Val Pro 
        115                 120                 125             


Ala Pro Ala Pro Ser Val Ser Gly Asp Gly Asp Gly Ile Glu Glu Asp 
    130                 135                 140                 


Ile Ala Pro Gly Leu Arg Val Trp Arg Arg Ala Leu Ser Glu Ala Arg 
145                 150                 155                 160 


Ser Ala Ala Gln Val Ala Leu Cys Ile Gln Gln Leu Gln Lys Ser Ile 
                165                 170                 175     


Ala Trp Glu 
            


<210> 3973
<211> 211
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 3973
Xaa Ile Gln Gln Ile Arg Met Glu Lys Glu Leu Arg Ala Gln Gln Ile 
1               5                   10                  15      


Leu Glu Ala Lys Lys Lys Lys Lys Glu Glu Ala Ala Asn Ala Lys Leu 
            20                  25                  30          


Leu Glu Ala Glu Lys Arg Ile Lys Glu Lys Glu Met Arg Arg Gln Gln 
        35                  40                  45              


Ala Val Leu Leu Lys His Gln Glu Leu Glu Arg His Arg Leu Asp Met 
    50                  55                  60                  


Glu Arg Glu Arg Arg Arg Gln His Met Met Leu Met Lys Ala Met Glu 
65                  70                  75                  80  


Ala Arg Lys Lys Ala Glu Glu Lys Glu Arg Leu Lys Gln Glu Lys Arg 
                85                  90                  95      


Asp Glu Lys Arg Leu Asn Lys Glu Arg Lys Leu Glu Gln Arg Arg Leu 
            100                 105                 110         


Glu Leu Glu Met Ala Lys Glu Leu Lys Lys Pro Asn Glu Asp Met Cys 
        115                 120                 125             


Leu Ala Asp Gln Lys Pro Leu Pro Glu Leu Pro Arg Ile Pro Gly Leu 
    130                 135                 140                 


Val Leu Ser Gly Ser Xaa Phe Ser Asp Cys Leu Met Val Val Gln Phe 
145                 150                 155                 160 


Leu Arg Asn Phe Gly Lys Val Leu Gly Phe Asp Val Asn Ile Asp Val 
                165                 170                 175     


Pro Asn Leu Ser Val Leu Gln Glu Gly Leu Leu Asn Ile Gly Asp Ser 
            180                 185                 190         


Met Gly Glu Val Gln Asp Leu Leu Val Arg Leu Leu Ser Ala Ala Val 
        195                 200                 205             


Cys Asp Pro 
    210     


<210> 3974
<211> 194
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<400> 3974
Xaa Asn Asn Val Asn Pro Val Lys Xaa Gln His His Ser His Pro Ala 
1               5                   10                  15      


Lys Ser Leu Val Glu Gln Phe Arg Gly Xaa Asp Ser Asp Ile Pro Ser 
            20                  25                  30          


Ser Lys Asp Ser Glu Asp Ser Asn Glu Asp Glu Glu Glu Asp Asp Glu 
        35                  40                  45              


Glu Glu Asp Glu Glu Asp Asp Glu Asp Asp Glu Ser Asp Asp Ser Gln 
    50                  55                  60                  


Ser Gly Xaa Ser Lys Arg Arg Arg Val Xaa Asp Glu Arg Glu Leu Arg 
65                  70                  75                  80  


Ile Pro Leu Glu Tyr Gly Trp Gln Arg Glu Xaa Arg Ile Arg Asn Phe 
                85                  90                  95      


Gly Gly Arg Leu Gln Gly Glu Val Ala Tyr Tyr Ala Pro Cys Gly Lys 
            100                 105                 110         


Lys Leu Arg Gln Tyr Pro Glu Val Ile Lys Tyr Leu Ser Arg Asn Gly 
        115                 120                 125             


Ile Met Asp Ile Ser Arg Asp Asn Phe Ser Phe Ser Ala Lys Ile Arg 
    130                 135                 140                 


Val Gly Asp Phe Tyr Glu Ala Arg Asp Gly Pro Gln Gly Met Gln Trp 
145                 150                 155                 160 


Cys Leu Leu Lys Glu Glu Asp Val Ile Pro Arg Ile Arg Ala Met Glu 
                165                 170                 175     


Gly Arg Arg Gly Arg Pro Pro Asn Pro Asp Arg Gln Arg Ala Arg Glu 
            180                 185                 190         


Glu Ser 
        


<210> 3975
<211> 193
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<400> 3975
Met Ala Arg Ala Arg Gln Glu Gly Ser Ser Pro Glu Pro Val Glu Gly 
1               5                   10                  15      


Leu Ala Arg Asp Gly Pro Arg Pro Phe Pro Leu Gly Arg Leu Val Pro 
            20                  25                  30          


Ser Ala Val Ser Cys Gly Leu Cys Glu Pro Gly Leu Ala Ala Ala Pro 
        35                  40                  45              


Ala Ala Pro Xaa Leu Leu Pro Ala Ala Tyr Leu Cys Ala Pro Xaa Ala 
    50                  55                  60                  


Pro Pro Ala Val Xaa Ala Ala Leu Gly Gly Ser Arg Trp Pro Gly Gly 
65                  70                  75                  80  


Pro Arg Ser Arg Pro Arg Gly Pro Arg Pro Asp Gly Pro Gln Pro Ser 
                85                  90                  95      


Leu Ser Leu Ala Glu Gln His Leu Glu Ser Pro Val Pro Ser Ala Pro 
            100                 105                 110         


Gly Ala Leu Ala Gly Gly Pro Xaa Gln Ala Ala Pro Gly Val Arg Gly 
        115                 120                 125             


Glu Glu Glu Gln Trp Ala Arg Glu Ile Gly Ala Gln Leu Arg Arg Met 
    130                 135                 140                 


Ala Asp Asp Leu Asn Ala Gln Tyr Glu Arg Arg Arg Gln Glu Glu Gln 
145                 150                 155                 160 


Gln Arg His Arg Pro Ser Pro Trp Arg Val Leu Tyr Asn Leu Ile Met 
                165                 170                 175     


Gly Leu Leu Pro Leu Pro Arg Gly His Arg Ala Pro Glu Met Glu Pro 
            180                 185                 190         


Asn 
    


<210> 3976
<211> 101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<400> 3976
Met Lys Phe Gly Met Gly Ser Ala Gln Ala Cys Pro Cys Gln Val Pro 
1               5                   10                  15      


Arg Ala Ala Ser Xaa Xaa Trp Val Pro Cys Gln Ile Cys Glu Xaa Arg 
            20                  25                  30          


Gly Ala Ala Ala Ala Pro Pro Leu Xaa Leu Glu Gly Pro Val Gln Ser 
        35                  40                  45              


His His Gly Xaa Pro Ala Leu Xaa Gln Gly Pro Gln Ser Pro Arg Asp 
    50                  55                  60                  


Gly Ala Gln Leu Gly Ala Cys Xaa Arg Pro Val Asp Val Arg Asp Ser 
65                  70                  75                  80  


Gly Gly Arg Pro Leu Pro Pro Pro Asp Xaa Leu Ala Ser Ala Gly Asp 
                85                  90                  95      


Phe Leu Cys Xaa Met 
            100     


<210> 3977
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<400> 3977
Met Lys Phe Gly Met Gly Ser Ala Gln Ala Cys Pro Cys Gln Val Pro 
1               5                   10                  15      


Arg Ala Ala Ser Xaa Xaa Trp Val Pro Cys Gln Ile Cys Gly Pro Gln 
            20                  25                  30          


Pro Ser Leu Ser Leu Ala Glu Gln His Leu Glu Ser Pro Val Pro Ser 
        35                  40                  45              


Ala Pro Gly Ala Leu Ala Gly Gly Pro Xaa Gln Ala Ala Pro Gly Val 
    50                  55                  60                  


Arg Gly Glu Glu Glu Gln Trp Ala Arg Glu Ile Gly Ala Gln Leu Arg 
65                  70                  75                  80  


Arg Met Ala Asp Asp Leu Asn Ala Gln Tyr Glu Arg Arg Arg Gln Glu 
                85                  90                  95      


Glu Gln Gln Arg His Arg Pro Ser Pro Trp Arg Val Leu Tyr Asn Leu 
            100                 105                 110         


Ile Met Gly Leu Leu Pro Leu Pro Arg Gly His Arg Ala Pro Glu Met 
        115                 120                 125             


Glu Pro Asn 
    130     


<210> 3978
<211> 261
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<400> 3978
Met Lys Phe Gly Met Gly Ser Ala Gln Ala Cys Pro Cys Gln Val Pro 
1               5                   10                  15      


Arg Ala Ala Ser Xaa Xaa Trp Val Pro Cys Gln Ile Cys Gly Pro Arg 
            20                  25                  30          


Glu Arg His Gly Pro Arg Xaa Pro Gly Gly Gln Leu Pro Gly Ala Arg 
        35                  40                  45              


Arg Gly Pro Gly Pro Arg Arg Pro Ala Pro Leu Pro Ala Arg Pro Pro 
    50                  55                  60                  


Gly Ala Leu Gly Ser Val Leu Arg Pro Leu Arg Ala Arg Pro Gly Cys 
65                  70                  75                  80  


Arg Pro Arg Arg Pro His Pro Ala Ala Arg Cys Leu Pro Leu Arg Pro 
                85                  90                  95      


His Arg Pro Xaa Arg Arg His Arg Arg Pro Gly Gly Phe Pro Leu Ala 
            100                 105                 110         


Trp Gly Ser Pro Gln Pro Ala Pro Arg Pro Ala Pro Gly Arg Ser Ser 
        115                 120                 125             


Ala Leu Ala Leu Ala Gly Gly Ala Ala Pro Gly Val Ala Arg Ala Gln 
    130                 135                 140                 


Arg Pro Gly Gly Ser Gly Gly Arg Ser His Pro Gly Gly Pro Gly Ser 
145                 150                 155                 160 


Pro Arg Gly Gly Gly Xaa Val Gly Pro Gly Asp Arg Gly Pro Ala Ala 
                165                 170                 175     


Ala Asp Gly Gly Arg Pro Gln Arg Xaa Val Arg Ala Ala Glu Xaa Arg 
            180                 185                 190         


Gly Ala Ala Ala Ala Pro Pro Leu Xaa Leu Glu Gly Pro Val Gln Ser 
        195                 200                 205             


His His Gly Xaa Pro Ala Leu Xaa Gln Gly Pro Gln Ser Pro Arg Asp 
    210                 215                 220                 


Gly Ala Gln Leu Gly Ala Cys Xaa Arg Pro Val Asp Val Arg Asp Ser 
225                 230                 235                 240 


Gly Gly Arg Pro Leu Pro Pro Pro Asp Xaa Leu Ala Ser Ala Gly Asp 
                245                 250                 255     


Phe Leu Cys Xaa Met 
            260     


<210> 3979
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<400> 3979
Asp Glu Ile Val Ala Glu Met Xaa Glu Xaa Glu Ile Val Xaa Ser Leu 
1               5                   10                  15      


Cys Pro Met Tyr Gly Ser Arg Phe Gly Tyr Ala Leu Ser Asn Gly Xaa 
            20                  25                  30          


Val Gly Val Tyr Asp Lys Xaa Ser Arg Tyr Trp Arg Ile Lys Ser Lys 
        35                  40                  45              


Asn His Ala Met Ser Ile His Ala Phe Asp Leu Asn Ser Asp Gly Val 
    50                  55                  60                  


Asn Glu Leu Ile Xaa Gly Trp Ser Asn Gly Lys Val Asp Ala Arg Ser 
65                  70                  75                  80  


Asp Arg Xaa Gly Glu Val Ile Phe Lys Asp Asn Phe Ser Ser Ala Ile 
                85                  90                  95      


Ala Gly Val Val Glu Gly Asp Tyr Arg Met Asp Gly His Ile His Pro 
            100                 105                 110         


Gly Leu Pro Ala Trp His Gly 
        115                 


<210> 3980
<211> 142
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<400> 3980
Leu Gln Val Glu Ala Asp Phe Pro Val Tyr Phe Glu Glu Leu Arg Lys 
1               5                   10                  15      


Val Leu Val Lys Val Asp Glu Tyr His Ser Val His Gln Lys Leu Ser 
            20                  25                  30          


Ala Asp Met Ala Asp His Ser Asn Leu Ile Arg Ser Leu Leu Val Gly 
        35                  40                  45              


Ala Glu Asp Ala Arg Leu Met Arg Asp Met Lys Xaa Met Lys Ser Arg 
    50                  55                  60                  


Tyr Met Glu Leu Tyr Asp Leu Asn Arg Asp Leu Leu Asn Gly Tyr Lys 
65                  70                  75                  80  


Ile Arg Cys Asn Asn His Xaa Glu Leu Leu Gly Asn Leu Lys Ala Val 
                85                  90                  95      


Asn Gln Ala Ile Gln Arg Ala Gly Arg Leu Arg Val Gly Lys Pro Lys 
            100                 105                 110         


Asn Gln Val Ile Xaa Ala Cys Arg Asp Ala Ile Arg Ser Asn Asn Ile 
        115                 120                 125             


Asn Xaa Leu Phe Lys Ile Met Arg Val Gly Xaa Ala Ser Ser 
    130                 135                 140         


<210> 3981
<211> 675
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<400> 3981
Met Leu Leu Pro Val Phe Xaa Leu Lys Leu Arg His Lys Ile Ser Pro 
1               5                   10                  15      


Arg Met Val Ala Ile Gly Arg Tyr Asp Gly Xaa His Pro Cys Leu Ala 
            20                  25                  30          


Ala Ala Xaa Gln Xaa Gly Lys Val Phe Ile His Asn Pro His Xaa Arg 
        35                  40                  45              


Asn Gln His Val Ser Ala Ser Arg Val Phe Gln Ser Pro Leu Glu Ser 
    50                  55                  60                  


Asp Val Ser Leu Leu Ser Ile Asn Gln Ala Val Ser Cys Leu Xaa Ala 
65                  70                  75                  80  


Gly Val Leu Asn Pro Glu Leu Gly Tyr Asp Ala Leu Leu Val Gly Xaa 
                85                  90                  95      


Gln Xaa Asn Leu Leu Ala Tyr Asp Val Tyr Asn Asn Ser Asp Leu Phe 
            100                 105                 110         


Tyr Arg Glu Val Ala Asp Gly Ala Asn Ala Ile Val Leu Gly Xaa Leu 
        115                 120                 125             


Gly Asp Ile Ser Ser Pro Leu Ala Ile Ile Gly Gly Asn Cys Ala Leu 
    130                 135                 140                 


Gln Gly Phe Asn His Glu Gly Ser Asp Leu Phe Trp Xaa Val Xaa Gly 
145                 150                 155                 160 


Asp Asn Val Asn Ser Leu Ala Leu Cys Asp Phe Asp Gly Asp Gly Lys 
                165                 170                 175     


Lys Glu Leu Leu Val Gly Ser Glu Asp Phe Asp Ile Arg Val Phe Lys 
            180                 185                 190         


Glu Asp Glu Ile Val Ala Glu Met Xaa Glu Xaa Glu Ile Val Xaa Ser 
        195                 200                 205             


Leu Cys Pro Met Tyr Gly Ser Arg Phe Gly Tyr Ala Leu Ser Asn Gly 
    210                 215                 220                 


Xaa Val Gly Val Tyr Asp Lys Xaa Ser Arg Tyr Trp Arg Ile Lys Ser 
225                 230                 235                 240 


Lys Asn His Ala Met Ser Ile His Ala Phe Asp Leu Asn Ser Asp Gly 
                245                 250                 255     


Val Asn Glu Leu Ile Xaa Gly Trp Ser Asn Gly Lys Val Asp Ala Arg 
            260                 265                 270         


Ser Asp Arg Xaa Gly Glu Val Ile Phe Lys Asp Asn Phe Ser Ser Ala 
        275                 280                 285             


Ile Ala Gly Val Val Glu Gly Asp Tyr Arg Met Asp Gly His Ile Gln 
    290                 295                 300                 


Leu Ile Cys Cys Ser Val Asp Gly Glu Ile Arg Gly Tyr Leu Pro Gly 
305                 310                 315                 320 


Xaa Ala Glu Met Arg Gly Asn Leu Met Asp Xaa Ser Ala Glu Gln Asp 
                325                 330                 335     


Leu Ile Arg Glu Leu Ser Gln Lys Lys Gln Asn Leu Leu Leu Glu Leu 
            340                 345                 350         


Arg Asn Tyr Glu Glu Asn Ala Lys Ala Glu Leu Ala Ser Pro Leu Asn 
        355                 360                 365             


Glu Ala Asp Gly His Arg Gly Ile Ile Pro Ala Asn Xaa Arg Leu His 
    370                 375                 380                 


Xaa Xaa Leu Ser Val Ser Leu Gly Asn Glu Xaa Gln Xaa Ala His Xaa 
385                 390                 395                 400 


Glu Leu Arg Ile Ser Xaa Ser Asn Asp Xaa Ile Ile Arg Ala Val Leu 
                405                 410                 415     


Ile Phe Ala Glu Gly Ile Phe Xaa Gly Glu Ser His Val Val His Pro 
            420                 425                 430         


Ser Ile His Asn Leu Ser Ser Ser Ile Cys Ile Pro Ile Val Pro Pro 
        435                 440                 445             


Lys Asp Val Pro Val Asp Leu His Leu Lys Ala Phe Val Gly Tyr Arg 
    450                 455                 460                 


Ser Ser Xaa Gln Phe His Val Phe Glu Ser Xaa Arg Gln Leu Pro Arg 
465                 470                 475                 480 


Phe Ser Met Tyr Ala Leu Xaa Ser Leu Asp Pro Ala Ser Glu Pro Ile 
                485                 490                 495     


Ser Tyr Val Asn Phe Xaa Ile Ala Glu Arg Ala Gln Arg Val Val Val 
            500                 505                 510         


Trp Leu Gly Gln Asn Phe Leu Leu Pro Glu Asp Xaa His Ile Gln Asn 
        515                 520                 525             


Ala Pro Phe Gln Val Cys Phe Xaa Ser Leu Arg Asn Gly Gly His Leu 
    530                 535                 540                 


His Ile Lys Ile Lys Leu Ser Gly Glu Val Asp Glu Tyr His Ser Val 
545                 550                 555                 560 


His Gln Lys Leu Ser Ala Asp Met Ala Asp His Ser Asn Leu Ile Arg 
                565                 570                 575     


Ser Leu Leu Val Gly Ala Glu Asp Ala Arg Leu Met Arg Asp Met Lys 
            580                 585                 590         


Xaa Met Lys Ser Arg Tyr Met Glu Leu Tyr Asp Leu Asn Arg Asp Leu 
        595                 600                 605             


Leu Asn Gly Tyr Lys Ile Arg Cys Asn Asn His Xaa Glu Leu Leu Gly 
    610                 615                 620                 


Asn Leu Lys Ala Val Asn Gln Ala Ile Gln Arg Ala Gly Arg Leu Arg 
625                 630                 635                 640 


Val Gly Lys Pro Lys Asn Gln Val Ile Xaa Ala Cys Arg Asp Ala Ile 
                645                 650                 655     


Arg Ser Asn Asn Ile Asn Xaa Leu Phe Lys Ile Met Arg Val Gly Xaa 
            660                 665                 670         


Ala Ser Ser 
        675 


<210> 3982
<211> 721
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<400> 3982
Met Leu Leu Pro Val Phe Xaa Leu Lys Leu Arg His Lys Ile Ser Pro 
1               5                   10                  15      


Arg Met Val Ala Ile Gly Arg Tyr Asp Gly Xaa His Pro Cys Leu Ala 
            20                  25                  30          


Ala Ala Xaa Gln Xaa Gly Lys Val Phe Ile His Asn Pro His Xaa Arg 
        35                  40                  45              


Asn Gln His Val Ser Ala Ser Arg Val Phe Gln Ser Pro Leu Glu Ser 
    50                  55                  60                  


Asp Val Ser Leu Leu Ser Ile Asn Gln Ala Val Ser Cys Leu Xaa Ala 
65                  70                  75                  80  


Gly Val Leu Asn Pro Glu Leu Gly Tyr Asp Ala Leu Leu Val Gly Xaa 
                85                  90                  95      


Gln Xaa Asn Leu Leu Ala Tyr Asp Val Tyr Asn Asn Ser Asp Leu Phe 
            100                 105                 110         


Tyr Arg Glu Val Ala Asp Gly Ala Asn Ala Ile Val Leu Gly Xaa Leu 
        115                 120                 125             


Gly Asp Ile Ser Ser Pro Leu Ala Ile Ile Gly Gly Asn Cys Ala Leu 
    130                 135                 140                 


Gln Gly Phe Asn His Glu Gly Ser Asp Leu Phe Trp Xaa Val Xaa Gly 
145                 150                 155                 160 


Asp Asn Val Asn Ser Leu Ala Leu Cys Asp Phe Asp Gly Asp Gly Lys 
                165                 170                 175     


Lys Glu Leu Leu Val Gly Ser Glu Asp Phe Asp Ile Arg Val Phe Lys 
            180                 185                 190         


Glu Asp Glu Ile Val Ala Glu Met Xaa Glu Xaa Glu Ile Val Xaa Ser 
        195                 200                 205             


Leu Cys Pro Met Tyr Gly Ser Arg Phe Gly Tyr Ala Leu Ser Asn Gly 
    210                 215                 220                 


Xaa Val Gly Val Tyr Asp Lys Xaa Ser Arg Tyr Trp Arg Ile Lys Ser 
225                 230                 235                 240 


Lys Asn His Ala Met Ser Ile His Ala Phe Asp Leu Asn Ser Asp Gly 
                245                 250                 255     


Val Asn Glu Leu Ile Xaa Gly Trp Ser Asn Gly Lys Val Asp Ala Arg 
            260                 265                 270         


Ser Asp Arg Xaa Gly Glu Val Ile Phe Lys Asp Asn Phe Ser Ser Ala 
        275                 280                 285             


Ile Ala Gly Val Val Glu Gly Asp Tyr Arg Met Asp Gly His Ile Gln 
    290                 295                 300                 


Leu Ile Cys Cys Ser Val Asp Gly Glu Ile Arg Gly Tyr Leu Pro Gly 
305                 310                 315                 320 


Xaa Ala Glu Met Arg Gly Asn Leu Met Asp Xaa Ser Ala Glu Gln Asp 
                325                 330                 335     


Leu Ile Arg Glu Leu Ser Gln Lys Lys Gln Asn Leu Leu Leu Glu Leu 
            340                 345                 350         


Arg Asn Tyr Glu Glu Asn Ala Lys Ala Glu Leu Ala Ser Pro Leu Asn 
        355                 360                 365             


Glu Ala Asp Gly His Arg Gly Ile Ile Pro Ala Asn Xaa Arg Leu His 
    370                 375                 380                 


Xaa Xaa Leu Ser Val Ser Leu Gly Asn Glu Xaa Gln Xaa Ala His Xaa 
385                 390                 395                 400 


Glu Leu Arg Ile Ser Xaa Ser Asn Asp Xaa Ile Ile Arg Ala Val Leu 
                405                 410                 415     


Ile Phe Ala Glu Gly Ile Phe Xaa Gly Glu Ser His Val Val His Pro 
            420                 425                 430         


Ser Ile His Asn Leu Ser Ser Ser Ile Cys Ile Pro Ile Val Pro Pro 
        435                 440                 445             


Lys Asp Val Pro Val Asp Leu His Leu Lys Ala Phe Val Gly Tyr Arg 
    450                 455                 460                 


Ser Ser Xaa Gln Phe His Val Phe Glu Ser Xaa Arg Gln Leu Pro Arg 
465                 470                 475                 480 


Phe Ser Met Tyr Ala Leu Xaa Ser Leu Asp Pro Ala Ser Glu Pro Ile 
                485                 490                 495     


Ser Tyr Val Asn Phe Xaa Ile Ala Glu Arg Ala Gln Arg Val Val Val 
            500                 505                 510         


Trp Leu Gly Gln Asn Phe Leu Leu Pro Glu Asp Xaa His Ile Gln Asn 
        515                 520                 525             


Ala Pro Phe Gln Val Cys Phe Xaa Ser Leu Arg Asn Gly Gly His Leu 
    530                 535                 540                 


His Ile Lys Ile Lys Leu Ser Gly Glu Ile Xaa Ile Asn Xaa Asp Asp 
545                 550                 555                 560 


Ile Asp Leu Ala Gly Asp Ile Ile Gln Ser Met Ala Ser Phe Phe Ala 
                565                 570                 575     


Ile Glu Asp Leu Gln Val Glu Ala Asp Phe Pro Val Tyr Phe Glu Glu 
            580                 585                 590         


Leu Arg Lys Val Leu Val Lys Val Asp Glu Tyr His Ser Val His Gln 
        595                 600                 605             


Lys Leu Ser Ala Asp Met Ala Asp His Ser Asn Leu Ile Arg Ser Leu 
    610                 615                 620                 


Leu Val Gly Ala Glu Asp Ala Arg Leu Met Arg Asp Met Lys Xaa Met 
625                 630                 635                 640 


Lys Ser Arg Tyr Met Glu Leu Tyr Asp Leu Asn Arg Asp Leu Leu Asn 
                645                 650                 655     


Gly Tyr Lys Ile Arg Cys Asn Asn His Xaa Glu Leu Leu Gly Asn Leu 
            660                 665                 670         


Lys Ala Val Asn Gln Ala Ile Gln Arg Ala Gly Arg Leu Arg Val Gly 
        675                 680                 685             


Lys Pro Lys Asn Gln Val Ile Xaa Ala Cys Arg Asp Ala Ile Arg Ser 
    690                 695                 700                 


Asn Asn Ile Asn Xaa Leu Phe Lys Ile Met Arg Val Gly Xaa Ala Ser 
705                 710                 715                 720 


Ser 
    


<210> 3983
<211> 85
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<400> 3983
Xaa Lys Xaa Met Lys Ser Arg Tyr Met Glu Leu Tyr Asp Leu Asn Arg 
1               5                   10                  15      


Asp Leu Leu Asn Gly Tyr Lys Ile Arg Cys Asn Asn His Xaa Glu Leu 
            20                  25                  30          


Leu Gly Asn Leu Lys Ala Val Asn Gln Ala Ile Gln Arg Ala Gly Arg 
        35                  40                  45              


Leu Arg Val Gly Lys Pro Lys Asn Gln Val Ile Xaa Ala Cys Arg Asp 
    50                  55                  60                  


Ala Ile Arg Ser Asn Asn Ile Asn Xaa Leu Phe Lys Ile Met Arg Val 
65                  70                  75                  80  


Gly Xaa Ala Ser Ser 
                85  


<210> 3984
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<400> 3984
Xaa Asn Leu Ser Ser Ser Ile Cys Ile Pro Ile Val Pro Pro Lys Asp 
1               5                   10                  15      


Val Pro Val Asp Leu His Leu Lys Ala Phe Val Gly Tyr Arg Ser Ser 
            20                  25                  30          


Xaa Gln Phe His Val Phe Glu Ser Xaa Arg Gln Leu Pro Arg Phe Ser 
        35                  40                  45              


Met Tyr Ala Leu Xaa Ser Leu Asp Pro Ala Ser Glu Pro Ile Ser Tyr 
    50                  55                  60                  


Val Asn Phe Xaa Ile Ala Glu Arg Ala Gln Arg Gln 
65                  70                  75      


<210> 3985
<211> 281
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<400> 3985
Glu Arg Val Ala Xaa Arg Xaa Gln Phe Pro Val Ser Xaa Glu Ser Gln 
1               5                   10                  15      


Lys Pro Arg Gln Lys Lys Ala Pro Glu Phe Pro Ile Leu Glu Lys Gln 
            20                  25                  30          


Asn Trp Leu Ile His Leu His Tyr Ile Arg Lys Asp Tyr Glu Ala Cys 
        35                  40                  45              


Lys Ala Val Ile Lys Glu Gln Leu Gln Glu Xaa Gln Gly Leu Cys Glu 
    50                  55                  60                  


Tyr Ala Ile Tyr Val Gln Ala Leu Ile Phe Arg Leu Glu Gly Asn Ile 
65                  70                  75                  80  


Gln Glu Ser Leu Glu Leu Phe Gln Xaa Cys Ala Val Leu Ser Pro Gln 
                85                  90                  95      


Ser Ala Asp Asn Leu Lys Gln Val Ala Arg Ser Leu Phe Leu Leu Gly 
            100                 105                 110         


Lys His Lys Ala Ala Ile Glu Val Tyr Asn Glu Ala Ala Lys Leu Asn 
        115                 120                 125             


Gln Lys Asp Trp Glu Ile Ser His Asn Leu Gly Val Cys Tyr Ile Tyr 
    130                 135                 140                 


Leu Lys Gln Phe Asn Lys Ala Gln Asp Gln Leu His Asn Ala Leu Asn 
145                 150                 155                 160 


Leu Asn Arg His Asp Leu Xaa Tyr Ile Met Leu Gly Lys Ile His Leu 
                165                 170                 175     


Leu Glu Gly Asp Leu Asp Lys Ala Ile Glu Val Tyr Lys Lys Ala Val 
            180                 185                 190         


Glu Phe Ser Pro Glu Asn Xaa Glu Leu Leu Xaa Xaa Leu Gly Leu Leu 
        195                 200                 205             


Tyr Leu Gln Ala Ile Leu Ala Ala Gly Ser Met Met Gln Xaa His Gly 
    210                 215                 220                 


Asp Phe Asp Val Ala Leu Xaa Lys Tyr Arg Val Val Ala Cys Ala Val 
225                 230                 235                 240 


Pro Glu Ser Pro Pro Leu Trp Asn Asn Ile Gly Met Cys Phe Phe Gly 
                245                 250                 255     


Lys Lys Lys Tyr Val Ala Ala Ile Ser Cys Leu Lys Arg Ala Asn Tyr 
            260                 265                 270         


Leu Ala Pro Phe Asp Trp Lys Ile Leu 
        275                 280     


<210> 3986
<211> 50
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<400> 3986
Met Ala Glu Glu Arg Val Ala Xaa Asp Cys Ser Pro Ser Trp Gly Ala 
1               5                   10                  15      


Leu Asp Gly Glu Gly Arg Leu Phe Xaa Ser Asn Gly Ser Tyr Arg Ser 
            20                  25                  30          


Ala Ile Phe Phe Cys Leu Gly Gly Leu Glu Glu Asn Ser Ile Ser Cys 
        35                  40                  45              


Ile Tyr 
    50  


<210> 3987
<211> 20
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<400> 3987
Met Ala Glu Glu Arg Val Ala Xaa Leu Gln Ser Phe Leu Phe Trp Arg 
1               5                   10                  15      


Ser Arg Xaa Gly 
            20  


<210> 3988
<211> 519
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<400> 3988
Met Ala Glu Glu Arg Val Ala Xaa Arg Xaa Gln Phe Pro Val Ser Xaa 
1               5                   10                  15      


Glu Ser Gln Lys Pro Arg Gln Lys Lys Ala Pro Glu Phe Pro Ile Leu 
            20                  25                  30          


Glu Lys Gln Asn Trp Leu Ile His Leu His Tyr Ile Arg Lys Asp Tyr 
        35                  40                  45              


Glu Ala Cys Lys Ala Val Ile Lys Glu Gln Leu Gln Glu Xaa Gln Gly 
    50                  55                  60                  


Leu Cys Glu Tyr Ala Ile Tyr Val Gln Ala Leu Ile Phe Arg Leu Glu 
65                  70                  75                  80  


Gly Asn Ile Gln Glu Ser Leu Glu Leu Phe Gln Xaa Cys Ala Val Leu 
                85                  90                  95      


Ser Pro Gln Ser Ala Asp Asn Leu Lys Gln Val Ala Arg Ser Leu Phe 
            100                 105                 110         


Leu Leu Gly Lys His Lys Ala Ala Ile Glu Val Tyr Asn Glu Ala Ala 
        115                 120                 125             


Lys Leu Asn Gln Lys Asp Trp Glu Ile Ser His Asn Leu Gly Val Cys 
    130                 135                 140                 


Tyr Ile Tyr Leu Lys Gln Phe Asn Lys Ala Gln Asp Gln Leu His Asn 
145                 150                 155                 160 


Ala Leu Asn Leu Asn Arg His Asp Leu Xaa Tyr Ile Met Leu Gly Lys 
                165                 170                 175     


Ile His Leu Leu Glu Gly Asp Leu Asp Lys Ala Ile Glu Val Tyr Lys 
            180                 185                 190         


Lys Ala Val Glu Phe Ser Pro Glu Asn Xaa Glu Leu Leu Xaa Xaa Leu 
        195                 200                 205             


Gly Leu Leu Tyr Leu Gln Leu Gly Ile Tyr Gln Lys Ala Phe Glu His 
    210                 215                 220                 


Leu Gly Asn Ala Leu Xaa Tyr Asp Pro Xaa Asn Tyr Lys Ala Ile Leu 
225                 230                 235                 240 


Ala Ala Gly Ser Met Met Gln Xaa His Gly Asp Phe Asp Val Ala Leu 
                245                 250                 255     


Xaa Lys Tyr Arg Val Val Ala Cys Ala Val Pro Glu Ser Pro Pro Leu 
            260                 265                 270         


Trp Asn Asn Ile Gly Met Cys Phe Phe Gly Lys Lys Lys Tyr Val Ala 
        275                 280                 285             


Ala Ile Ser Cys Leu Lys Arg Ala Asn Tyr Leu Ala Pro Phe Asp Trp 
    290                 295                 300                 


Lys Ile Leu Tyr Asn Leu Gly Leu Val His Leu Xaa Met Gln Gln Tyr 
305                 310                 315                 320 


Ala Ser Ala Phe His Phe Leu Ser Ala Ala Ile Asn Phe Gln Pro Lys 
                325                 330                 335     


Met Gly Glu Leu Tyr Met Leu Leu Ala Val Ala Leu Xaa Asn Leu Glu 
            340                 345                 350         


Asp Ile Glu Asn Ala Lys Arg Ala Tyr Ala Glu Ala Val His Leu Asp 
        355                 360                 365             


Lys Cys Asn Pro Leu Val Asn Leu Asn Tyr Ala Val Leu Leu Tyr Asn 
    370                 375                 380                 


Gln Gly Glu Lys Lys Asn Ala Leu Ala Gln Tyr Gln Glu Met Glu Lys 
385                 390                 395                 400 


Lys Val Ser Leu Leu Lys Asp Asn Ser Ser Leu Glu Phe Asp Ser Glu 
                405                 410                 415     


Met Val Glu Met Ala Gln Lys Leu Gly Ala Ala Leu Gln Val Gly Glu 
            420                 425                 430         


Ala Leu Val Trp Xaa Lys Pro Val Lys Asp Pro Lys Ser Lys His Gln 
        435                 440                 445             


Xaa Xaa Ser Xaa Ser Lys Pro Ala Ser Phe Gln Gln Pro Leu Gly Ser 
    450                 455                 460                 


Asn Gln Ala Leu Gly Gln Ala Met Ser Ser Ala Ala Ala Tyr Arg Xaa 
465                 470                 475                 480 


Leu Pro Ser Gly Ala Gly Gly Xaa Ser Gln Phe Xaa Lys Pro Pro Ser 
                485                 490                 495     


Leu Pro Leu Glu Pro Glu Pro Ala Val Glu Ser Ser Pro Xaa Glu Xaa 
            500                 505                 510         


Ser Glu Gln Ile Arg Glu Lys 
        515                 


<210> 3989
<211> 142
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<400> 3989
Met Ala Glu Glu Arg Val Ala Xaa Arg Xaa Gln Phe Pro Val Ser Xaa 
1               5                   10                  15      


Glu Ser Gln Lys Pro Arg Gln Lys Lys Ala Pro Glu Phe Pro Ile Leu 
            20                  25                  30          


Glu Lys Gln Asn Trp Leu Ile His Leu His Tyr Ile Arg Lys Asp Tyr 
        35                  40                  45              


Glu Ala Cys Lys Ala Val Ile Lys Glu Gln Leu Gln Glu Xaa Gln Gly 
    50                  55                  60                  


Leu Cys Glu Tyr Ala Ile Tyr Val Gln Ala Leu Ile Phe Arg Leu Glu 
65                  70                  75                  80  


Gly Asn Ile Gln Glu Ser Leu Glu Leu Phe Gln Xaa Cys Ala Val Leu 
                85                  90                  95      


Ser Pro Gln Ser Ala Asp Asn Leu Lys Gln Val Ala Arg Ser Leu Phe 
            100                 105                 110         


Leu Leu Gly Lys His Lys Ala Ala Ile Glu Val Tyr Asn Glu Ala Ala 
        115                 120                 125             


Lys Leu Asn Gln Lys Asp Trp Pro Arg Arg Ser Ala Ile Xaa 
    130                 135                 140         


<210> 3990
<211> 103
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 3990
Met Ala Glu Glu Arg Val Ala Xaa Arg Xaa Gln Phe Pro Val Ser Xaa 
1               5                   10                  15      


Glu Ser Gln Lys Pro Arg Gln Lys Lys Ala Pro Glu Phe Pro Ile Leu 
            20                  25                  30          


Glu Lys Gln Asn Trp Leu Ile His Leu His Tyr Ile Arg Lys Asp Tyr 
        35                  40                  45              


Glu Ala Cys Lys Ala Val Ile Lys Glu Gln Leu Gln Glu Xaa Gln Gly 
    50                  55                  60                  


Leu Cys Glu Tyr Ala Ile Tyr Val Gln Asp Phe Phe Trp Glu Asn Ile 
65                  70                  75                  80  


Lys Leu Pro Leu Lys Tyr Ile Met Lys Gln Leu Asn Ser Xaa Arg Lys 
                85                  90                  95      


Ile Gly Arg Ser Ala Ile Xaa 
            100             


<210> 3991
<211> 33
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<400> 3991
Met Ala Glu Glu Arg Val Ala Xaa Arg Xaa Gln Phe Pro Val Ser Xaa 
1               5                   10                  15      


Glu Ser Gln Lys Pro Arg Gln Lys Lys Gly Asp Phe Leu Leu Ala Phe 
            20                  25                  30          


Ser 
    


<210> 3992
<211> 67
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<400> 3992
Met Ala Glu Glu Arg Val Ala Xaa Arg Xaa Gln Phe Pro Val Ser Xaa 
1               5                   10                  15      


Glu Ser Gln Lys Pro Arg Gln Lys Lys Gly Gly Val Gly Val Ser Asn 
            20                  25                  30          


Asp Leu Glu Tyr Gln Lys Phe Asn Leu Tyr Ile Tyr Ser Ser Arg Val 
        35                  40                  45              


Ser Tyr Phe Gly Glu Ala Glu Leu Val Asp Ser Ser Ser Leu Tyr Pro 
    50                  55                  60                  


Glu Arg Leu 
65          


<210> 3993
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 3993
Met Ala Glu Glu Arg Val Ala Xaa Val Ser Ala Glu Ile Leu Phe Ser 
1               5                   10                  15      


Cys Pro Ala Ala Gly Gln Gly Lys Leu Ala Gly Gly Phe Cys Pro Met 
            20                  25                  30          


Gln Arg Phe Leu Glu Arg Gly Gly Ala Gly Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Gly Arg Gly Asp Xaa Val Pro Phe Leu Leu Ser Arg Glu Leu Val Ala 
    50                  55                  60                  


Trp Gly Lys Ser Gly Tyr Leu Ala Ala Gln Val Leu Phe 
65                  70                  75          


<210> 3994
<211> 141
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 3994
Met Ala Leu Xaa Val Val Pro Ser Phe Ser Val Ser Gly Val Trp Lys 
1               5                   10                  15      


Arg Xaa Gln Phe Pro Val Ser Xaa Glu Ser Gln Lys Pro Arg Gln Lys 
            20                  25                  30          


Lys Glu Phe Pro Ile Leu Glu Lys Gln Asn Trp Leu Ile His Leu His 
        35                  40                  45              


Tyr Ile Arg Lys Asp Tyr Glu Ala Cys Lys Ala Val Ile Lys Glu Gln 
    50                  55                  60                  


Leu Gln Glu Xaa Gln Gly Leu Cys Glu Tyr Ala Ile Tyr Val Gln Ala 
65                  70                  75                  80  


Leu Ile Phe Arg Leu Glu Gly Asn Ile Gln Glu Ser Leu Glu Leu Phe 
                85                  90                  95      


Gln Xaa Cys Ala Val Leu Ser Pro Gln Ser Ala Asp Asn Leu Lys Gln 
            100                 105                 110         


Val Ala Arg Ser Leu Phe Leu Leu Gly Lys His Lys Ala Ala Ile Glu 
        115                 120                 125             


Val Tyr Asn Glu Ala Ala Lys Leu Asn Gln Lys Asp Trp 
    130                 135                 140     


<210> 3995
<211> 347
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<400> 3995
Met Leu Gly Lys Ile His Leu Leu Glu Gly Asp Leu Asp Lys Ala Ile 
1               5                   10                  15      


Glu Val Tyr Lys Lys Ala Val Glu Phe Ser Pro Glu Asn Xaa Glu Leu 
            20                  25                  30          


Leu Xaa Xaa Leu Gly Leu Leu Tyr Leu Gln Leu Gly Ile Tyr Gln Lys 
        35                  40                  45              


Ala Phe Glu His Leu Gly Asn Ala Leu Xaa Tyr Asp Pro Xaa Asn Tyr 
    50                  55                  60                  


Lys Ala Ile Leu Ala Ala Gly Ser Met Met Gln Xaa His Gly Asp Phe 
65                  70                  75                  80  


Asp Val Ala Leu Xaa Lys Tyr Arg Val Val Ala Cys Ala Val Pro Glu 
                85                  90                  95      


Ser Pro Pro Leu Trp Asn Asn Ile Gly Met Cys Phe Phe Gly Lys Lys 
            100                 105                 110         


Lys Tyr Val Ala Ala Ile Ser Cys Leu Lys Arg Ala Asn Tyr Leu Ala 
        115                 120                 125             


Pro Phe Asp Trp Lys Ile Leu Tyr Asn Leu Gly Leu Val His Leu Xaa 
    130                 135                 140                 


Met Gln Gln Tyr Ala Ser Ala Phe His Phe Leu Ser Ala Ala Ile Asn 
145                 150                 155                 160 


Phe Gln Pro Lys Met Gly Glu Leu Tyr Met Leu Leu Ala Val Ala Leu 
                165                 170                 175     


Xaa Asn Leu Glu Asp Ile Glu Asn Ala Lys Arg Ala Tyr Ala Glu Ala 
            180                 185                 190         


Val His Leu Asp Lys Cys Asn Pro Leu Val Asn Leu Asn Tyr Ala Val 
        195                 200                 205             


Leu Leu Tyr Asn Gln Gly Glu Lys Lys Asn Ala Leu Ala Gln Tyr Gln 
    210                 215                 220                 


Glu Met Glu Lys Lys Val Ser Leu Leu Lys Asp Asn Ser Ser Leu Glu 
225                 230                 235                 240 


Phe Asp Ser Glu Met Val Glu Met Ala Gln Lys Leu Gly Ala Ala Leu 
                245                 250                 255     


Gln Val Gly Glu Ala Leu Val Trp Xaa Lys Pro Val Lys Asp Pro Lys 
            260                 265                 270         


Ser Lys His Gln Xaa Xaa Ser Xaa Ser Lys Pro Ala Ser Phe Gln Gln 
        275                 280                 285             


Pro Leu Gly Ser Asn Gln Ala Leu Gly Gln Ala Met Ser Ser Ala Ala 
    290                 295                 300                 


Ala Tyr Arg Xaa Leu Pro Ser Gly Ala Gly Gly Xaa Ser Gln Phe Xaa 
305                 310                 315                 320 


Lys Pro Pro Ser Leu Pro Leu Glu Pro Glu Pro Ala Val Glu Ser Ser 
                325                 330                 335     


Pro Xaa Glu Xaa Ser Glu Gln Ile Arg Glu Lys 
            340                 345         


<210> 3996
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<400> 3996
Xaa Asn Phe Gln Pro Lys Met Gly Glu Leu Tyr Met Leu Leu Ala Ala 
1               5                   10                  15      


Glu Leu Ser Ser Cys Ser Ala Phe Phe Val Ala Val Ala Leu Xaa Asn 
            20                  25                  30          


Leu Glu Asp Ile Glu Asn Ala Lys Arg Ala Tyr Ala Glu Ala Val His 
        35                  40                  45              


Leu Asp Lys Cys Asn Pro Leu Val Asn Leu Asn Tyr Ala Val Leu Leu 
    50                  55                  60                  


Tyr Asn Gln Gly Glu Lys Lys Asn Ala Leu Ala Gln Tyr Gln Glu Met 
65                  70                  75                  80  


Glu Lys Lys Val Ser Leu Leu Lys Asp Asn Ser Ser Leu Glu Phe Asp 
                85                  90                  95      


Ser Glu Met Val Glu Met Ala Gln Lys Leu Gly Ala Ala Leu Gln Val 
            100                 105                 110         


Gly Glu Ala Leu Val Trp Xaa Lys Pro Val Lys Asp Pro Lys Ser Lys 
        115                 120                 125             


His Gln Xaa Xaa Ser Xaa Ser Lys Pro Ala Ser Phe Gln Gln Pro Leu 
    130                 135                 140                 


Gly Ser Asn Gln Ala Leu Gly Gln Ala Met Ser Ser Ala Ala Ala Tyr 
145                 150                 155                 160 


Arg Xaa Leu Pro Ser Gly Ala Gly Gly Xaa Ser Gln Phe Xaa Lys Pro 
                165                 170                 175     


Pro Ser Leu Pro Leu 
            180     


<210> 3997
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<400> 3997
Asp Val Leu Ser Lys Glu Ala Xaa Lys Arg Lys Ile Asn Leu Asn Ile 
1               5                   10                  15      


Ser Tyr Glu Ile Asn Glu Val Ser Val Lys His Xaa Leu Lys Leu Ile 
            20                  25                  30          


His Pro Lys Leu Glu Tyr Gln Leu Leu Leu Ala Lys Lys Val Gln Leu 
        35                  40                  45              


Ile Asp Ala Leu Lys Glu Leu Gln Ile His Glu Gly Asn Xaa Asn Phe 
    50                  55                  60                  


Leu Ile Pro Glu Tyr His Cys Ile Leu Glu Glu Ala Asp His Leu Gln 
65                  70                  75                  80  


Glu Glu Tyr Lys Lys Gln Pro Ala His Leu Glu Arg Leu Tyr Gly Met 
                85                  90                  95      


Ile Xaa Asp Leu Phe Ile Asp Lys Phe Lys Phe Lys Gly Xaa Asn Val 
            100                 105                 110         


Lys Xaa Lys Val Pro Leu Leu Leu Glu Ile Leu Asp Ser Tyr Asp Gln 
        115                 120                 125             


Asn Ala Leu Ile Ser Phe Phe Asp Ala Ala 
    130                 135             


<210> 3998
<211> 672
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<400> 3998
Met Asp Leu Ile Leu Asn Arg Met Asp Tyr Leu Gln Val Gly Val Xaa 
1               5                   10                  15      


Ser Gln Lys Xaa Met Lys Leu Ile Pro Ala Ser Arg His Arg Ala Xaa 
            20                  25                  30          


Gln Lys Val Val Ile Gly Asp His Asp Gly Val Val Met Cys Phe Gly 
        35                  40                  45              


Met Lys Lys Gly Glu Ala Ala Ala Val Phe Lys Xaa Leu Pro Gly Pro 
    50                  55                  60                  


Lys Ile Ala Arg Leu Glu Leu Gly Gly Val Ile Asn Xaa Pro Gln Glu 
65                  70                  75                  80  


Lys Ile Phe Ile Ala Ala Ala Ser Glu Ile Arg Gly Phe Xaa Lys Arg 
                85                  90                  95      


Gly Lys Gln Phe Leu Ser Phe Glu Xaa Asn Leu Xaa Glu Ser Ile Lys 
            100                 105                 110         


Ala Met His Ile Ser Gly Ser Asp Leu Phe Leu Ser Ala Ser Tyr Ile 
        115                 120                 125             


Tyr Asn His Tyr Cys Asp Cys Lys Asp Gln His Tyr Tyr Leu Ser Gly 
    130                 135                 140                 


Asp Lys Ile Asn Asp Val Ile Cys Leu Pro Val Glu Arg Leu Ser Arg 
145                 150                 155                 160 


Ile Xaa Pro Val Leu Ala Cys Gln Asp Arg Val Leu Arg Val Leu Gln 
                165                 170                 175     


Gly Ser Asp Val Met Tyr Ala Val Glu Val Pro Gly Pro Pro Xaa Val 
            180                 185                 190         


Leu Ala Leu His Asn Gly Asn Gly Gly Asp Ser Gly Glu Asp Leu Leu 
        195                 200                 205             


Phe Gly Xaa Ser Asp Gly Lys Leu Ala Leu Ile Gln Ile Xaa Xaa Ser 
    210                 215                 220                 


Lys Pro Val Arg Lys Trp Glu Ile Gln Asn Glu Lys Lys Arg Gly Gly 
225                 230                 235                 240 


Ile Leu Cys Ile Asp Ser Phe Asp Ile Val Gly Asp Gly Val Lys Asp 
                245                 250                 255     


Leu Leu Val Gly Arg Asp Asp Gly Met Val Glu Val Tyr Ser Phe Asp 
            260                 265                 270         


Asn Ala Asn Glu Pro Val Leu Arg Phe Asp Gln Met Leu Ser Glu Ser 
        275                 280                 285             


Val Xaa Ser Ile Gln Gly Gly Cys Val Gly Lys Asp Ser Tyr Asp Glu 
    290                 295                 300                 


Ile Val Val Ser Xaa Tyr Ser Gly Trp Val Xaa Gly Leu Xaa Xaa Glu 
305                 310                 315                 320 


Pro Ile His Lys Glu Ser Gly Pro Gly Glu Glu Leu Lys Ile Asn Gln 
                325                 330                 335     


Glu Met Gln Asn Lys Ile Ser Ser Leu Arg Asn Glu Leu Glu His Leu 
            340                 345                 350         


Gln Tyr Lys Val Leu Gln Glu Arg Glu Asn Tyr Gln Gln Ser Ser Gln 
        355                 360                 365             


Ser Ser Lys Ala Lys Ser Ala Val Pro Ser Phe Gly Ile Asn Asp Lys 
    370                 375                 380                 


Phe Xaa Leu Asn Lys Asp Asp Ala Ser Tyr Ser Leu Ile Leu Glu Val 
385                 390                 395                 400 


Gln Xaa Ala Ile Asp Asn Val Leu Ile Gln Ser Asp Val Pro Ile Asp 
                405                 410                 415     


Leu Leu Asp Val Asp Lys Asn Ser Ala Val Val Ser Phe Ser Ser Cys 
            420                 425                 430         


Asp Ser Glu Ser Asn Asp Asn Phe Leu Leu Ala Xaa Tyr Arg Cys Gln 
        435                 440                 445             


Ala Asp Xaa Xaa Arg Leu Glu Leu Lys Ile Arg Ser Ile Glu Gly Gln 
    450                 455                 460                 


Tyr Gly Xaa Leu Gln Ala Tyr Val Xaa Pro Arg Ile Gln Pro Lys Xaa 
465                 470                 475                 480 


Cys Gln Val Arg Gln Tyr His Ile Lys Pro Leu Ser Leu His Gln Arg 
                485                 490                 495     


Xaa His Phe Ile Asp His Asp Arg Pro Met Asn Xaa Leu Xaa Leu Xaa 
            500                 505                 510         


Gly Gln Phe Ser Phe Ala Glu Val His Ser Trp Val Val Phe Cys Leu 
        515                 520                 525             


Pro Glu Val Pro Glu Lys Pro Pro Ala Gly Glu Cys Val Xaa Phe Tyr 
    530                 535                 540                 


Phe Gln Asn Xaa Phe Leu Asp Xaa Gln Leu Glu Ser Xaa Tyr Arg Lys 
545                 550                 555                 560 


Gly Glu Gly Val Phe Lys Ser Asp Asn Ile Ser Xaa Ile Ser Ile Leu 
                565                 570                 575     


Lys Asp Val Leu Ser Lys Glu Ala Xaa Lys Arg Lys Ile Asn Leu Asn 
            580                 585                 590         


Ile Ser Tyr Glu Ile Asn Glu Val Ser Val Lys His Xaa Leu Lys Leu 
        595                 600                 605             


Ile His Pro Lys Leu Glu Tyr Gln Leu Leu Leu Ala Lys Lys Val Gln 
    610                 615                 620                 


Leu Ile Asp Ala Leu Lys Glu Leu Gln Ile His Glu Gly Asn Xaa Asn 
625                 630                 635                 640 


Phe Leu Ile Pro Glu Tyr His Cys Ile Leu Glu Glu Ala Asp His Leu 
                645                 650                 655     


Gln Glu Glu Tyr Lys Lys Gln Pro Ala His Leu Glu Arg Leu Tyr Gly 
            660                 665                 670         


<210> 3999
<211> 715
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<400> 3999
Met Asp Leu Ile Leu Asn Arg Met Asp Tyr Leu Gln Val Gly Val Xaa 
1               5                   10                  15      


Ser Gln Lys Xaa Met Lys Leu Ile Pro Ala Ser Arg His Arg Ala Xaa 
            20                  25                  30          


Gln Lys Val Val Ile Gly Asp His Asp Gly Val Val Met Cys Phe Gly 
        35                  40                  45              


Met Lys Lys Gly Glu Ala Ala Ala Val Phe Lys Xaa Leu Pro Gly Pro 
    50                  55                  60                  


Lys Ile Ala Arg Leu Glu Leu Gly Gly Val Ile Asn Xaa Pro Gln Glu 
65                  70                  75                  80  


Lys Ile Phe Ile Ala Ala Ala Ser Glu Ile Arg Gly Phe Xaa Lys Arg 
                85                  90                  95      


Gly Lys Gln Phe Leu Ser Phe Glu Xaa Asn Leu Xaa Glu Ser Ile Lys 
            100                 105                 110         


Ala Met His Ile Ser Gly Ser Asp Leu Phe Leu Ser Ala Ser Tyr Ile 
        115                 120                 125             


Tyr Asn His Tyr Cys Asp Cys Lys Asp Gln His Tyr Tyr Leu Ser Gly 
    130                 135                 140                 


Asp Lys Ile Asn Asp Val Ile Cys Leu Pro Val Glu Arg Leu Ser Arg 
145                 150                 155                 160 


Ile Xaa Pro Val Leu Ala Cys Gln Asp Arg Val Leu Arg Val Leu Gln 
                165                 170                 175     


Gly Ser Asp Val Met Tyr Ala Val Glu Val Pro Gly Pro Pro Xaa Val 
            180                 185                 190         


Leu Ala Leu His Asn Gly Asn Gly Gly Asp Ser Gly Glu Asp Leu Leu 
        195                 200                 205             


Phe Gly Xaa Ser Asp Gly Lys Leu Ala Leu Ile Gln Ile Xaa Xaa Ser 
    210                 215                 220                 


Lys Pro Val Arg Lys Trp Glu Ile Gln Asn Glu Lys Lys Arg Gly Gly 
225                 230                 235                 240 


Ile Leu Cys Ile Asp Ser Phe Asp Ile Val Gly Asp Gly Val Lys Asp 
                245                 250                 255     


Leu Leu Val Gly Arg Asp Asp Gly Met Val Glu Val Tyr Ser Phe Asp 
            260                 265                 270         


Asn Ala Asn Glu Pro Val Leu Arg Phe Asp Gln Met Leu Ser Glu Ser 
        275                 280                 285             


Val Xaa Ser Ile Gln Gly Gly Cys Val Gly Lys Asp Ser Tyr Asp Glu 
    290                 295                 300                 


Ile Val Val Ser Xaa Tyr Ser Gly Trp Val Xaa Gly Leu Xaa Xaa Glu 
305                 310                 315                 320 


Pro Ile His Lys Glu Ser Gly Pro Gly Glu Glu Leu Lys Ile Asn Gln 
                325                 330                 335     


Glu Met Gln Asn Lys Ile Ser Ser Leu Arg Asn Glu Leu Glu His Leu 
            340                 345                 350         


Gln Tyr Lys Val Leu Gln Glu Arg Glu Asn Tyr Gln Gln Ser Ser Gln 
        355                 360                 365             


Ser Ser Lys Ala Lys Ser Ala Val Pro Ser Phe Gly Ile Asn Asp Lys 
    370                 375                 380                 


Phe Xaa Leu Asn Lys Asp Asp Ala Ser Tyr Ser Leu Ile Leu Glu Val 
385                 390                 395                 400 


Gln Xaa Ala Ile Asp Asn Val Leu Ile Gln Ser Asp Val Pro Ile Asp 
                405                 410                 415     


Leu Leu Asp Val Asp Lys Asn Ser Ala Val Val Ser Phe Ser Ser Cys 
            420                 425                 430         


Asp Ser Glu Ser Asn Asp Asn Phe Leu Leu Ala Xaa Tyr Arg Cys Gln 
        435                 440                 445             


Ala Asp Xaa Xaa Arg Leu Glu Leu Lys Ile Arg Ser Ile Glu Gly Gln 
    450                 455                 460                 


Tyr Gly Xaa Leu Gln Ala Tyr Val Xaa Pro Arg Ile Gln Pro Lys Xaa 
465                 470                 475                 480 


Cys Gln Val Arg Gln Tyr His Ile Lys Pro Leu Ser Leu His Gln Arg 
                485                 490                 495     


Xaa His Phe Ile Asp His Asp Arg Pro Met Asn Xaa Leu Xaa Leu Xaa 
            500                 505                 510         


Gly Gln Phe Ser Phe Ala Glu Val His Ser Trp Val Val Phe Cys Leu 
        515                 520                 525             


Pro Glu Val Pro Glu Lys Pro Pro Ala Gly Glu Cys Val Xaa Phe Tyr 
    530                 535                 540                 


Phe Gln Asn Xaa Phe Leu Asp Xaa Gln Leu Glu Ser Xaa Tyr Arg Lys 
545                 550                 555                 560 


Gly Glu Gly Val Phe Lys Ser Asp Asn Ile Ser Xaa Ile Ser Ile Leu 
                565                 570                 575     


Lys Asp Val Leu Ser Lys Glu Ala Xaa Lys Arg Lys Ile Asn Leu Asn 
            580                 585                 590         


Ile Ser Tyr Glu Ile Asn Glu Val Ser Val Lys His Xaa Leu Lys Leu 
        595                 600                 605             


Ile His Pro Lys Leu Glu Tyr Gln Leu Leu Leu Ala Lys Lys Val Gln 
    610                 615                 620                 


Leu Ile Asp Ala Leu Lys Glu Leu Gln Ile His Glu Gly Asn Xaa Asn 
625                 630                 635                 640 


Phe Leu Ile Pro Glu Tyr His Cys Ile Leu Glu Glu Ala Asp His Leu 
                645                 650                 655     


Gln Glu Glu Tyr Lys Lys Gln Pro Ala His Leu Glu Arg Leu Tyr Gly 
            660                 665                 670         


Met Ile Xaa Asp Leu Phe Ile Asp Lys Phe Lys Phe Lys Gly Xaa Asn 
        675                 680                 685             


Val Lys Xaa Lys Val Pro Leu Leu Leu Glu Ile Leu Asp Ser Tyr Asp 
    690                 695                 700                 


Gln Asn Ala Leu Ile Ser Phe Phe Asp Ala Ala 
705                 710                 715 


<210> 4000
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4000
Met Lys Gly Ser Asn Arg Asn Lys Asp His Ser Ala Glu 
1               5                   10              


<210> 4001
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4001
Met Lys Gly Ser Asn Arg Asn Lys Asp His Ser Ala Glu Gly Glu Gly 
1               5                   10                  15      


Val Gly Lys Arg Pro Lys Arg Lys 
            20                  


<210> 4002
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<400> 4002
Met Lys Gly Ser Asn Arg Asn Lys Asp His Ser Ala Glu Gly Glu Gly 
1               5                   10                  15      


Val Gly Lys Arg Pro Lys Arg Lys Cys Leu Gln Trp His Pro Leu Leu 
            20                  25                  30          


Ala Lys Lys Leu Leu Asp Phe Ser Glu Glu Glu Glu Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Asp Ile Asp Lys Xaa Arg Ile Glu Ala Gln Tyr Lys Asn Arg 
    50                  55                  60                  


Gly Leu Ala Cys Leu Val Leu Ser Ser Cys Leu Arg Asn Glu Asn Gly 
65                  70                  75                  80  


Ala Trp His Ile Val Gln Leu Leu Gly Ala Asp Gly Leu Glu Gln Asp 
                85                  90                  95      


Val Gly Glu Xaa Glu Asp Asp Glu Ser Pro Glu Gln Arg Ala Arg Arg 
            100                 105                 110         


Pro Met Asn Ala Phe Leu Leu 
        115                 


<210> 4003
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<400> 4003
Met Lys Gly Ser Asn Arg Asn Lys Asp His Ser Ala Glu Gly Glu Gly 
1               5                   10                  15      


Val Gly Lys Arg Pro Lys Arg Lys Cys Leu Gln Trp His Pro Leu Leu 
            20                  25                  30          


Ala Lys Lys Leu Leu Asp Phe Ser Glu Glu Glu Glu Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Asp Ile Asp Lys Val Gln Leu Leu Gly Ala Asp Gly Leu Glu 
    50                  55                  60                  


Gln Asp Val Gly Glu Xaa Glu 
65                  70      


<210> 4004
<211> 85
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<400> 4004
Met Lys Gly Ser Asn Arg Asn Lys Asp His Ser Ala Glu Gly Glu Gly 
1               5                   10                  15      


Val Gly Lys Arg Pro Lys Arg Lys Cys Leu Gln Trp His Pro Leu Leu 
            20                  25                  30          


Ala Lys Lys Leu Leu Asp Phe Ser Glu Glu Glu Glu Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Asp Ile Asp Lys Val Gln Leu Leu Gly Ala Asp Gly Leu Glu 
    50                  55                  60                  


Gln Asp Val Gly Glu Xaa Glu Asp Asp Glu Ser Pro Glu Gln Arg Ala 
65                  70                  75                  80  


Arg Arg Pro Met Asn 
                85  


<210> 4005
<211> 98
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<400> 4005
Met Lys Gly Ser Asn Arg Asn Lys Asp His Ser Ala Glu Gly Glu Gly 
1               5                   10                  15      


Val Gly Lys Arg Pro Lys Arg Lys Cys Leu Gln Trp His Pro Leu Leu 
            20                  25                  30          


Ala Lys Lys Leu Leu Asp Phe Ser Glu Glu Glu Glu Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Asp Ile Asp Lys Val Gln Leu Leu Gly Ala Asp Gly Leu Glu 
    50                  55                  60                  


Gln Asp Val Gly Glu Xaa Glu Asp Asp Glu Ser Pro Glu Gln Arg Ala 
65                  70                  75                  80  


Arg Arg Pro Met Asn Ala Phe Leu Leu Phe Cys Lys Arg His Arg Ser 
                85                  90                  95      


Leu Val 
        


<210> 4006
<211> 114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 4006
Met Lys Gly Ser Asn Arg Asn Lys Asp His Ser Ala Glu Gly Glu Gly 
1               5                   10                  15      


Val Gly Lys Arg Pro Lys Arg Lys Cys Leu Gln Trp His Pro Leu Leu 
            20                  25                  30          


Ala Lys Lys Leu Leu Asp Phe Ser Glu Glu Glu Glu Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Asp Ile Asp Lys Val Gln Leu Leu Gly Ala Asp Gly Leu Glu 
    50                  55                  60                  


Gln Asp Val Gly Glu Xaa Glu Asp Asp Glu Ser Pro Glu Gln Arg Ala 
65                  70                  75                  80  


Arg Arg Pro Met Asn Ala Phe Leu Leu Phe Cys Lys Arg His Arg Ser 
                85                  90                  95      


Leu Val Arg Gln Glu His Pro Arg Leu Asp Asn Arg Gly Ala Xaa Lys 
            100                 105                 110         


Ile Leu 
        


<210> 4007
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 4007
Met Lys Gly Ser Asn Arg Asn Lys Asp His Ser Ala Glu Gly Glu Gly 
1               5                   10                  15      


Val Gly Lys Arg Pro Lys Arg Lys Cys Leu Gln Trp His Pro Leu Leu 
            20                  25                  30          


Ala Lys Lys Leu Leu Asp Phe Ser Glu Glu Glu Glu Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Asp Ile Asp Lys Val Gln Leu Leu Gly Ala Asp Gly Leu Glu 
    50                  55                  60                  


Gln Asp Val Gly Glu Xaa Glu Asp Asp Glu Ser Pro Glu Gln Arg Ala 
65                  70                  75                  80  


Arg Arg Pro Met Asn Ala Phe Leu Leu Phe Cys Lys Arg His Arg Ser 
                85                  90                  95      


Leu Val Arg Gln Glu His Pro Arg Leu Asp Asn Arg Gly Ala Xaa Lys 
            100                 105                 110         


Ile Leu Ala Asp Trp Trp Ala Val Leu Asp Pro Lys Glu Lys Gln Lys 
        115                 120                 125             


Tyr Xaa Asp Met Ala Lys Glu Tyr Lys Asp Ala Phe Met Lys Ala Asn 
    130                 135                 140                 


<210> 4008
<211> 149
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 4008
Met Lys Gly Ser Asn Arg Asn Lys Asp His Ser Ala Glu Gly Glu Gly 
1               5                   10                  15      


Val Gly Lys Arg Pro Lys Arg Lys Cys Leu Gln Trp His Pro Leu Leu 
            20                  25                  30          


Ala Lys Lys Leu Leu Asp Phe Ser Glu Glu Glu Glu Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Asp Ile Asp Lys Val Gln Leu Leu Gly Ala Asp Gly Leu Glu 
    50                  55                  60                  


Gln Asp Val Gly Glu Xaa Glu Asp Asp Glu Ser Pro Glu Gln Arg Ala 
65                  70                  75                  80  


Arg Arg Pro Met Asn Ala Phe Leu Leu Phe Cys Lys Arg His Arg Ser 
                85                  90                  95      


Leu Val Arg Gln Glu His Pro Arg Leu Asp Asn Arg Gly Ala Xaa Lys 
            100                 105                 110         


Ile Leu Ala Asp Trp Trp Ala Val Leu Asp Pro Lys Glu Lys Gln Lys 
        115                 120                 125             


Tyr Xaa Asp Met Ala Lys Glu Tyr Lys Asp Ala Phe Met Lys Ala Asn 
    130                 135                 140                 


Pro Gly Tyr Lys Trp 
145                 


<210> 4009
<211> 159
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(153)
<223> Selenocysteine

<400> 4009
Met Lys Gly Ser Asn Arg Asn Lys Asp His Ser Ala Glu Gly Glu Gly 
1               5                   10                  15      


Val Gly Lys Arg Pro Lys Arg Lys Cys Leu Gln Trp His Pro Leu Leu 
            20                  25                  30          


Ala Lys Lys Leu Leu Asp Phe Ser Glu Glu Glu Glu Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Asp Ile Asp Lys Val Gln Leu Leu Gly Ala Asp Gly Leu Glu 
    50                  55                  60                  


Gln Asp Val Gly Glu Xaa Glu Asp Asp Glu Ser Pro Glu Gln Arg Ala 
65                  70                  75                  80  


Arg Arg Pro Met Asn Ala Phe Leu Leu Phe Cys Lys Arg His Arg Ser 
                85                  90                  95      


Leu Val Arg Gln Glu His Pro Arg Leu Asp Asn Arg Gly Ala Xaa Lys 
            100                 105                 110         


Ile Leu Ala Asp Trp Trp Ala Val Leu Asp Pro Lys Glu Lys Gln Lys 
        115                 120                 125             


Tyr Xaa Asp Met Ala Lys Glu Tyr Lys Asp Ala Phe Met Lys Ala Asn 
    130                 135                 140                 


Pro Gly Tyr Lys Trp Cys Pro Xaa Xaa Asn Lys Pro Val Lys Ser 
145                 150                 155                 


<210> 4010
<211> 166
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<400> 4010
Met Lys Gly Ser Asn Arg Asn Lys Asp His Ser Ala Glu Gly Glu Gly 
1               5                   10                  15      


Val Gly Lys Arg Pro Lys Arg Lys Cys Leu Gln Trp His Pro Leu Leu 
            20                  25                  30          


Ala Lys Lys Leu Leu Asp Phe Ser Glu Glu Glu Glu Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Asp Ile Asp Lys Val Gln Leu Leu Gly Ala Asp Gly Leu Glu 
    50                  55                  60                  


Gln Asp Val Gly Glu Xaa Glu Asp Asp Glu Ser Pro Glu Gln Arg Ala 
65                  70                  75                  80  


Arg Arg Pro Met Asn Ala Phe Leu Leu Phe Cys Lys Arg His Arg Ser 
                85                  90                  95      


Leu Val Arg Gln Glu His Pro Arg Leu Asp Asn Arg Gly Ala Xaa Lys 
            100                 105                 110         


Ile Leu Ala Asp Trp Trp Ala Val Leu Asp Pro Lys Glu Lys Gln Lys 
        115                 120                 125             


Tyr Xaa Asp Met Ala Lys Glu Tyr Lys Asp Ala Phe Met Lys Ala Asn 
    130                 135                 140                 


Pro Gly Tyr Lys Trp Cys Pro Xaa Xaa Asn Lys Pro Val Lys Ser Pro 
145                 150                 155                 160 


Xaa Pro Xaa Val Asn Pro 
                165     


<210> 4011
<211> 193
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<400> 4011
Met Lys Gly Ser Asn Arg Asn Lys Asp His Ser Ala Glu Gly Glu Gly 
1               5                   10                  15      


Val Gly Lys Arg Pro Lys Arg Lys Cys Leu Gln Trp His Pro Leu Leu 
            20                  25                  30          


Ala Lys Lys Leu Leu Asp Phe Ser Glu Glu Glu Glu Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Asp Ile Asp Lys Val Gln Leu Leu Gly Ala Asp Gly Leu Glu 
    50                  55                  60                  


Gln Asp Val Gly Glu Xaa Glu Asp Asp Glu Ser Pro Glu Gln Arg Ala 
65                  70                  75                  80  


Arg Arg Pro Met Asn Ala Phe Leu Leu Phe Cys Lys Arg His Arg Ser 
                85                  90                  95      


Leu Val Arg Gln Glu His Pro Arg Leu Asp Asn Arg Gly Ala Xaa Lys 
            100                 105                 110         


Ile Leu Ala Asp Trp Trp Ala Val Leu Asp Pro Lys Glu Lys Gln Lys 
        115                 120                 125             


Tyr Xaa Asp Met Ala Lys Glu Tyr Lys Asp Ala Phe Met Lys Ala Asn 
    130                 135                 140                 


Pro Gly Tyr Lys Trp Cys Pro Xaa Xaa Asn Lys Pro Val Lys Ser Pro 
145                 150                 155                 160 


Xaa Pro Xaa Val Asn Pro Arg Lys Lys Leu Trp Ala Phe Pro Ser Asp 
                165                 170                 175     


Ser Ser Arg Asp Leu Pro Ser Pro Lys Lys Ala Lys Xaa Glu Glu Met 
            180                 185                 190         


Pro 
    


<210> 4012
<211> 205
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<400> 4012
Met Lys Gly Ser Asn Arg Asn Lys Asp His Ser Ala Glu Gly Glu Gly 
1               5                   10                  15      


Val Gly Lys Arg Pro Lys Arg Lys Cys Leu Gln Trp His Pro Leu Leu 
            20                  25                  30          


Ala Lys Lys Leu Leu Asp Phe Ser Glu Glu Glu Glu Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Asp Ile Asp Lys Val Gln Leu Leu Gly Ala Asp Gly Leu Glu 
    50                  55                  60                  


Gln Asp Val Gly Glu Xaa Glu Asp Asp Glu Ser Pro Glu Gln Arg Ala 
65                  70                  75                  80  


Arg Arg Pro Met Asn Ala Phe Leu Leu Phe Cys Lys Arg His Arg Ser 
                85                  90                  95      


Leu Val Arg Gln Glu His Pro Arg Leu Asp Asn Arg Gly Ala Xaa Lys 
            100                 105                 110         


Ile Leu Ala Asp Trp Trp Ala Val Leu Asp Pro Lys Glu Lys Gln Lys 
        115                 120                 125             


Tyr Xaa Asp Met Ala Lys Glu Tyr Lys Asp Ala Phe Met Lys Ala Asn 
    130                 135                 140                 


Pro Gly Tyr Lys Trp Cys Pro Xaa Xaa Asn Lys Pro Val Lys Ser Pro 
145                 150                 155                 160 


Xaa Pro Xaa Val Asn Pro Arg Lys Lys Leu Trp Ala Phe Pro Ser Asp 
                165                 170                 175     


Ser Ser Arg Asp Leu Pro Ser Pro Lys Lys Ala Lys Xaa Glu Glu Met 
            180                 185                 190         


Pro Gln Leu Asn Phe Gly Met Ala Asp Pro Xaa Gln Met 
        195                 200                 205 


<210> 4013
<211> 448
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<400> 4013
Met Lys Gly Ser Asn Arg Asn Lys Asp His Ser Ala Glu Gly Glu Gly 
1               5                   10                  15      


Val Gly Lys Arg Pro Lys Arg Lys Cys Leu Gln Trp His Pro Leu Leu 
            20                  25                  30          


Ala Lys Lys Leu Leu Asp Phe Ser Glu Glu Glu Glu Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Asp Ile Asp Lys Val Gln Leu Leu Gly Ala Asp Gly Leu Glu 
    50                  55                  60                  


Gln Asp Val Gly Glu Xaa Glu Asp Asp Glu Ser Pro Glu Gln Arg Ala 
65                  70                  75                  80  


Arg Arg Pro Met Asn Ala Phe Leu Leu Phe Cys Lys Arg His Arg Ser 
                85                  90                  95      


Leu Val Arg Gln Glu His Pro Arg Leu Asp Asn Arg Gly Ala Xaa Lys 
            100                 105                 110         


Ile Leu Ala Asp Trp Trp Ala Val Leu Asp Pro Lys Glu Lys Gln Lys 
        115                 120                 125             


Tyr Xaa Asp Met Ala Lys Glu Tyr Lys Asp Ala Phe Met Lys Ala Asn 
    130                 135                 140                 


Pro Gly Tyr Lys Trp Cys Pro Xaa Xaa Asn Lys Pro Val Lys Ser Pro 
145                 150                 155                 160 


Xaa Pro Xaa Val Asn Pro Arg Lys Lys Leu Trp Ala Phe Pro Ser Asp 
                165                 170                 175     


Ser Ser Arg Asp Leu Pro Ser Pro Lys Lys Ala Lys Xaa Glu Glu Met 
            180                 185                 190         


Pro Gln Leu Asn Phe Gly Met Ala Asp Pro Xaa Gln Met Gly Gly Leu 
        195                 200                 205             


Ser Met Leu Leu Leu Ala Gly Glu His Ala Leu Gly Xaa Pro Glu Val 
    210                 215                 220                 


Ser Ser Gly Xaa Cys Arg Pro Asp Val Ser Glu Ser Pro Glu Leu Arg 
225                 230                 235                 240 


Gln Lys Ser Pro Leu Phe Gln Phe Ala Glu Ile Ser Ser Ser Xaa Ser 
                245                 250                 255     


His Ser Asp Ala Ser Xaa Lys Gln Cys Gln Xaa Ser Ala Leu Phe Gln 
            260                 265                 270         


Phe Ala Glu Ile Ser Ser Asn Xaa Ser Gln Leu Gly Gly Ala Glu Pro 
        275                 280                 285             


Val Lys Arg Cys Gly Lys Ser Ala Leu Phe Gln Leu Ala Glu Met Cys 
    290                 295                 300                 


Leu Ala Ser Glu Gly Met Lys Met Glu Glu Ser Lys Leu Ile Lys Ala 
305                 310                 315                 320 


Lys Glu Ser Asp Gly Gly Arg Ile Lys Glu Leu Glu Lys Gly Lys Glu 
                325                 330                 335     


Glu Lys Glu Ile Lys Met Glu Lys Xaa Asp Glu Xaa Arg Leu Gln Lys 
            340                 345                 350         


Glu Ala Glu Phe Glu Lys Ser Ala Lys Glu Asn Leu Arg Asp Ser Lys 
        355                 360                 365             


Glu Leu Arg Asn Phe Glu Ala Leu Gln Ile Asp Asp Ile Met Ala Ile 
    370                 375                 380                 


Lys Met Glu Asp Pro Lys Glu Ile Arg Lys Glu Glu Leu Glu Glu Asp 
385                 390                 395                 400 


His Lys Cys Ser His Phe Pro Asp Phe Ser Tyr Ser Ala Ser Ser Lys 
                405                 410                 415     


Ile Ile Ile Ser Asp Val Pro Ser Arg Lys Asp His Met Cys His Pro 
            420                 425                 430         


His Gly Ile Met Ile Ile Glu Asp Pro Ala Ala Leu Asn Lys Pro Glu 
        435                 440                 445             


<210> 4014
<211> 628
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<400> 4014
Met Lys Gly Ser Asn Arg Asn Lys Asp His Ser Ala Glu Gly Glu Gly 
1               5                   10                  15      


Val Gly Lys Arg Pro Lys Arg Lys Cys Leu Gln Trp His Pro Leu Leu 
            20                  25                  30          


Ala Lys Lys Leu Leu Asp Phe Ser Glu Glu Glu Glu Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Asp Ile Asp Lys Val Gln Leu Leu Gly Ala Asp Gly Leu Glu 
    50                  55                  60                  


Gln Asp Val Gly Glu Xaa Glu Asp Asp Glu Ser Pro Glu Gln Arg Ala 
65                  70                  75                  80  


Arg Arg Pro Met Asn Ala Phe Leu Leu Phe Cys Lys Arg His Arg Ser 
                85                  90                  95      


Leu Val Arg Gln Glu His Pro Arg Leu Asp Asn Arg Gly Ala Xaa Lys 
            100                 105                 110         


Ile Leu Ala Asp Trp Trp Ala Val Leu Asp Pro Lys Glu Lys Gln Lys 
        115                 120                 125             


Tyr Xaa Asp Met Ala Lys Glu Tyr Lys Asp Ala Phe Met Lys Ala Asn 
    130                 135                 140                 


Pro Gly Tyr Lys Trp Cys Pro Xaa Xaa Asn Lys Pro Val Lys Ser Pro 
145                 150                 155                 160 


Xaa Pro Xaa Val Asn Pro Arg Lys Lys Leu Trp Ala Phe Pro Ser Asp 
                165                 170                 175     


Ser Ser Arg Asp Leu Pro Ser Pro Lys Lys Ala Lys Xaa Glu Glu Met 
            180                 185                 190         


Pro Gln Leu Asn Phe Gly Met Ala Asp Pro Xaa Gln Met Gly Gly Leu 
        195                 200                 205             


Ser Met Leu Leu Leu Ala Gly Glu His Ala Leu Gly Xaa Pro Glu Val 
    210                 215                 220                 


Ser Ser Gly Xaa Cys Arg Pro Asp Val Ser Glu Ser Pro Glu Leu Arg 
225                 230                 235                 240 


Gln Lys Ser Pro Leu Phe Gln Phe Ala Glu Ile Ser Ser Ser Xaa Ser 
                245                 250                 255     


His Ser Asp Ala Ser Xaa Lys Gln Cys Gln Xaa Ser Ala Leu Phe Gln 
            260                 265                 270         


Phe Ala Glu Ile Ser Ser Asn Xaa Ser Gln Leu Gly Gly Ala Glu Pro 
        275                 280                 285             


Val Lys Arg Cys Gly Lys Ser Ala Leu Phe Gln Leu Ala Glu Glu Asn 
    290                 295                 300                 


Glu Ala Gln Glu Lys Glu Xaa Pro Leu Ile Met Lys Gly Val Gly Met 
305                 310                 315                 320 


Lys Lys Ala Gly His Leu Val Arg Val Gly Pro Val Gly Ala Arg Ser 
                325                 330                 335     


Ser Arg Arg Gln Ser Gln Lys Lys Xaa Val Ser Leu Ala Pro Gln Ser 
            340                 345                 350         


Trp Met Lys Asn Leu Lys Lys Asn Ser Xaa Ala Ser Leu Asn Ile Val 
        355                 360                 365             


Leu Leu His Leu Xaa Gly Asn Val Tyr Leu Ser Gln Glu Lys Arg Arg 
    370                 375                 380                 


Arg Leu Glu Met Cys Pro Gln Asn Arg Leu Lys Pro Ala Lys Val Leu 
385                 390                 395                 400 


Ser Ser Leu Arg Lys Arg Xaa Tyr Ser Xaa Lys Leu Ser Ala Asn Ile 
                405                 410                 415     


Ser Xaa Lys Arg Arg Ser Pro Met Phe Arg Lys Lys Glu Val Gly Ile 
            420                 425                 430         


Asn Gly Gln Xaa Ser Asn Ser Ser Trp Met Pro Phe Xaa Leu Gln Lys 
        435                 440                 445             


Pro Tyr Phe Gln Lys Xaa Glu Xaa Pro Trp Ser Leu Phe Ile Arg Leu 
    450                 455                 460                 


Lys Ile Ser His Pro Phe Ser Xaa Leu Gln Ser Gln Gln Gln Arg Lys 
465                 470                 475                 480 


Asn Leu Trp Trp Ala Ala Lys Arg Glu Lys Gln Gly Lys Pro Arg Leu 
                485                 490                 495     


His Xaa Leu Ser Gly Gln Gln Met Ala Gly Tyr His Gln Gln Glu Val 
            500                 505                 510         


Leu Trp Met Xaa Asn Gln Arg Asn Asn Cys Arg Gly Val Ser Leu Lys 
        515                 520                 525             


Gln Leu Arg Gln Xaa Ala Met Xaa Asn Ala His Xaa Xaa Pro Arg Ser 
    530                 535                 540                 


Gly Arg Arg Gly Ala Val Leu Gln Lys Cys Leu Pro Cys Leu Arg Ser 
545                 550                 555                 560 


Leu Ala Ser Leu Arg Trp Leu Lys Trp Gln Pro Trp Lys Met Cys Xaa 
                565                 570                 575     


Glu Val Arg Gly Gln Leu Arg Ser Pro Met Met Asp Ser Gln Lys Lys 
            580                 585                 590         


Cys Arg Arg Leu Leu Tyr Leu Phe Pro Ala Leu Xaa Ser Glu Ala Pro 
        595                 600                 605             


Phe His Cys Lys Xaa Leu Cys Phe Xaa Tyr Tyr Pro Ser Leu Val Phe 
    610                 615                 620                 


Xaa Glu Gly Cys 
625             


<210> 4015
<211> 891
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<400> 4015
Met Lys Gly Ser Asn Arg Asn Lys Asp His Ser Ala Glu Gly Glu Gly 
1               5                   10                  15      


Val Gly Lys Arg Pro Lys Arg Lys Cys Leu Gln Trp His Pro Leu Leu 
            20                  25                  30          


Ala Lys Lys Leu Leu Asp Phe Ser Glu Glu Glu Glu Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Asp Ile Asp Lys Val Gln Leu Leu Gly Ala Asp Gly Leu Glu 
    50                  55                  60                  


Gln Asp Val Gly Glu Xaa Glu Asp Asp Glu Ser Pro Glu Gln Arg Ala 
65                  70                  75                  80  


Arg Arg Pro Met Asn Ala Phe Leu Leu Phe Cys Lys Arg His Arg Ser 
                85                  90                  95      


Leu Val Arg Gln Glu His Pro Arg Leu Asp Asn Arg Gly Ala Xaa Lys 
            100                 105                 110         


Ile Leu Ala Asp Trp Trp Ala Val Leu Asp Pro Lys Glu Lys Gln Lys 
        115                 120                 125             


Tyr Xaa Asp Met Ala Lys Glu Tyr Lys Asp Ala Phe Met Lys Ala Asn 
    130                 135                 140                 


Pro Gly Tyr Lys Trp Cys Pro Xaa Xaa Asn Lys Pro Val Lys Ser Pro 
145                 150                 155                 160 


Xaa Pro Xaa Val Asn Pro Arg Lys Lys Leu Trp Ala Phe Pro Ser Asp 
                165                 170                 175     


Ser Ser Arg Asp Leu Pro Ser Pro Lys Lys Ala Lys Xaa Glu Glu Met 
            180                 185                 190         


Pro Gln Leu Asn Phe Gly Met Ala Asp Pro Xaa Gln Met Gly Gly Leu 
        195                 200                 205             


Ser Met Leu Leu Leu Ala Gly Glu His Ala Leu Gly Xaa Pro Glu Val 
    210                 215                 220                 


Ser Ser Gly Xaa Cys Arg Pro Asp Val Ser Glu Ser Pro Glu Leu Arg 
225                 230                 235                 240 


Gln Lys Ser Pro Leu Phe Gln Phe Ala Glu Ile Ser Ser Ser Xaa Ser 
                245                 250                 255     


His Ser Asp Ala Ser Xaa Lys Gln Cys Gln Xaa Ser Ala Leu Phe Gln 
            260                 265                 270         


Phe Ala Glu Ile Ser Ser Asn Xaa Ser Gln Leu Gly Gly Ala Glu Pro 
        275                 280                 285             


Val Lys Arg Cys Gly Lys Ser Ala Leu Phe Gln Leu Ala Glu Met Cys 
    290                 295                 300                 


Leu Ala Ser Glu Gly Met Lys Met Glu Glu Ser Lys Leu Ile Lys Ala 
305                 310                 315                 320 


Lys Glu Ser Asp Gly Gly Arg Ile Lys Glu Leu Glu Lys Gly Lys Glu 
                325                 330                 335     


Glu Lys Glu Ile Lys Met Glu Lys Xaa Asp Glu Xaa Arg Leu Gln Lys 
            340                 345                 350         


Glu Ala Glu Phe Glu Lys Ser Ala Lys Glu Asn Leu Arg Asp Ser Lys 
        355                 360                 365             


Glu Leu Arg Asn Phe Glu Ala Leu Gln Ile Asp Asp Ile Met Ala Ile 
    370                 375                 380                 


Lys Met Glu Asp Pro Lys Glu Ile Arg Lys Glu Glu Leu Glu Glu Asp 
385                 390                 395                 400 


His Lys Cys Ser His Phe Pro Asp Phe Ser Tyr Ser Ala Ser Ser Lys 
                405                 410                 415     


Ile Ile Ile Ser Asp Val Pro Ser Arg Lys Asp His Met Cys His Pro 
            420                 425                 430         


His Gly Ile Met Ile Ile Glu Asp Pro Ala Ala Leu Asn Lys Pro Glu 
        435                 440                 445             


Lys Leu Lys Lys Lys Lys Lys Lys Ser Lys Met Asp Arg His Gly Asn 
    450                 455                 460                 


Asp Lys Ser Xaa Pro Lys Lys Xaa Cys Lys Lys Arg Gln Ser Ser Glu 
465                 470                 475                 480 


Ser Asp Ile Glu Ser Val Ile Tyr Xaa Ile Glu Ala Val Ala Lys Gly 
                485                 490                 495     


Asp Trp Gly Ile Glu Lys Leu Gly Asp Xaa Pro Arg Lys Lys Val Arg 
            500                 505                 510         


Xaa Ser Ser Ser Gly Lys Gly Ser Ile Leu Asp Ala Lys Pro Pro Lys 
        515                 520                 525             


Lys Lys Val Lys Ser Arg Glu Lys Lys Met Ser Lys Glu Lys Ser Ser 
    530                 535                 540                 


Asp Xaa Xaa Lys Glu Ser Arg Pro Pro Asp Phe Ile Ser Ile Ser Ala 
545                 550                 555                 560 


Ser Lys Asn Ile Ser Gly Glu Xaa Pro Glu Gly Ile Lys Ala Glu Pro 
                565                 570                 575     


Leu Xaa Pro Met Glu Asp Ala Leu Pro Pro Ser Leu Ser Gly Gln Ala 
            580                 585                 590         


Lys Pro Glu Asp Ser Asp Cys His Arg Lys Ile Glu Xaa Cys Gly Ser 
        595                 600                 605             


Arg Lys Ser Glu Arg Ser Cys Lys Gly Ala Leu Tyr Lys Xaa Leu Val 
    610                 615                 620                 


Ser Glu Gly Met Leu Xaa Ser Leu Arg Ala Asn Val Asp Arg Gly Lys 
625                 630                 635                 640 


Arg Ser Ser Gly Lys Gly Asn Ser Ser Asp His Glu Gly Cys Trp Asn 
                645                 650                 655     


Glu Glu Ser Trp Xaa Phe Ser Gln Ser Gly Xaa Ser Gly Ser Lys Lys 
            660                 665                 670         


Phe Lys Lys Xaa Lys Pro Lys Glu Asp Cys Leu Leu Gly Ser Ala Lys 
        675                 680                 685             


Leu Asp Glu Glu Phe Glu Lys Lys Phe Asn Ser Leu Pro Gln Tyr Ser 
    690                 695                 700                 


Pro Val Xaa Phe Asp Arg Lys Cys Val Pro Val Pro Arg Lys Lys Lys 
705                 710                 715                 720 


Lys Xaa Gly Asn Val Ser Ser Glu Pro Xaa Lys Xaa Ser Lys Ala Ile 
                725                 730                 735     


Phe Ser Glu Asp Arg Asn Xaa Met Glu Pro Val His Lys Val Lys Asn 
            740                 745                 750         


Ile Pro Ser Ile Phe Asn Xaa Pro Glu Pro Xaa Xaa Xaa Gln Glu Pro 
        755                 760                 765             


Leu Val Gly Ser Gln Lys Arg Lys Ala Arg Lys Xaa Lys Ile Xaa His 
    770                 775                 780                 


Leu Val Arg Xaa Ala Asp Gly Arg Val Ser Pro Ala Gly Gly Xaa Leu 
785                 790                 795                 800 


Asp Asp Lys Pro Lys Glu Gln Leu Gln Arg Ser Leu Pro Lys Ala Xaa 
                805                 810                 815     


Glu Xaa Asp Cys Asn Asp Lys Cys Ser His Asn Xaa Glu Val Gly Glu 
            820                 825                 830         


Xaa Arg Ser Ser Xaa Pro Glu Met Pro Ala Val Ser Ala Phe Phe Ser 
        835                 840                 845             


Leu Ala Ala Leu Ala Glu Val Ala Ala Met Glu Asn Val His Arg Gly 
    850                 855                 860                 


Gln Arg Ser Xaa Pro Leu Xaa His Asp Gly Gln Pro Lys Glu Met Pro 
865                 870                 875                 880 


Gln Ala Pro Val Leu Ile Ser Cys Ala Asp Gln 
                885                 890     


<210> 4016
<211> 911
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<400> 4016
Met Lys Gly Ser Asn Arg Asn Lys Asp His Ser Ala Glu Gly Glu Gly 
1               5                   10                  15      


Val Gly Lys Arg Pro Lys Arg Lys Cys Leu Gln Trp His Pro Leu Leu 
            20                  25                  30          


Ala Lys Lys Leu Leu Asp Phe Ser Glu Glu Glu Glu Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Asp Ile Asp Lys Val Gln Leu Leu Gly Ala Asp Gly Leu Glu 
    50                  55                  60                  


Gln Asp Val Gly Glu Xaa Glu Asp Asp Glu Ser Pro Glu Gln Arg Ala 
65                  70                  75                  80  


Arg Arg Pro Met Asn Ala Phe Leu Leu Phe Cys Lys Arg His Arg Ser 
                85                  90                  95      


Leu Val Arg Gln Glu His Pro Arg Leu Asp Asn Arg Gly Ala Xaa Lys 
            100                 105                 110         


Ile Leu Ala Asp Trp Trp Ala Val Leu Asp Pro Lys Glu Lys Gln Lys 
        115                 120                 125             


Tyr Xaa Asp Met Ala Lys Glu Tyr Lys Asp Ala Phe Met Lys Ala Asn 
    130                 135                 140                 


Pro Gly Tyr Lys Trp Cys Pro Xaa Xaa Asn Lys Pro Val Lys Ser Pro 
145                 150                 155                 160 


Xaa Pro Xaa Val Asn Pro Arg Lys Lys Leu Trp Ala Phe Pro Ser Asp 
                165                 170                 175     


Ser Ser Arg Asp Leu Pro Ser Pro Lys Lys Ala Lys Xaa Glu Glu Met 
            180                 185                 190         


Pro Gln Leu Asn Phe Gly Met Ala Asp Pro Xaa Gln Met Gly Gly Leu 
        195                 200                 205             


Ser Met Leu Leu Leu Ala Gly Glu His Ala Leu Gly Xaa Pro Glu Val 
    210                 215                 220                 


Ser Ser Gly Xaa Cys Arg Pro Asp Val Ser Glu Ser Pro Glu Leu Arg 
225                 230                 235                 240 


Gln Lys Ser Pro Leu Phe Gln Phe Ala Glu Ile Ser Ser Ser Xaa Ser 
                245                 250                 255     


His Ser Asp Ala Ser Xaa Lys Gln Cys Gln Xaa Ser Ala Leu Phe Gln 
            260                 265                 270         


Phe Ala Glu Ile Ser Ser Asn Xaa Ser Gln Leu Gly Gly Ala Glu Pro 
        275                 280                 285             


Val Lys Arg Cys Gly Lys Ser Ala Leu Phe Gln Leu Ala Glu Met Cys 
    290                 295                 300                 


Leu Ala Ser Glu Gly Met Lys Met Glu Glu Ser Lys Leu Ile Lys Ala 
305                 310                 315                 320 


Lys Glu Ser Asp Gly Gly Arg Ile Lys Glu Leu Glu Lys Gly Lys Glu 
                325                 330                 335     


Glu Lys Glu Ile Lys Met Glu Lys Xaa Asp Glu Xaa Arg Leu Gln Lys 
            340                 345                 350         


Glu Ala Glu Phe Glu Lys Ser Ala Lys Glu Asn Leu Arg Asp Ser Lys 
        355                 360                 365             


Glu Leu Arg Asn Phe Glu Ala Leu Gln Ile Asp Asp Ile Met Ala Ile 
    370                 375                 380                 


Lys Met Glu Asp Pro Lys Glu Ile Arg Lys Glu Glu Leu Glu Glu Asp 
385                 390                 395                 400 


His Lys Cys Ser His Phe Pro Asp Phe Ser Tyr Ser Ala Ser Ser Lys 
                405                 410                 415     


Ile Ile Ile Ser Asp Val Pro Ser Arg Lys Asp His Met Cys His Pro 
            420                 425                 430         


His Gly Ile Met Ile Ile Glu Asp Pro Ala Ala Leu Asn Lys Pro Glu 
        435                 440                 445             


Lys Leu Lys Lys Lys Lys Lys Lys Ser Lys Met Asp Arg His Gly Asn 
    450                 455                 460                 


Asp Lys Ser Xaa Pro Lys Lys Xaa Cys Lys Lys Arg Gln Ser Ser Glu 
465                 470                 475                 480 


Ser Asp Ile Glu Ser Val Ile Tyr Xaa Ile Glu Ala Val Ala Lys Gly 
                485                 490                 495     


Asp Trp Gly Ile Glu Lys Leu Gly Asp Xaa Pro Arg Lys Lys Val Arg 
            500                 505                 510         


Xaa Ser Ser Ser Gly Lys Gly Ser Ile Leu Asp Ala Lys Pro Pro Lys 
        515                 520                 525             


Lys Lys Val Lys Ser Arg Glu Lys Lys Met Ser Lys Glu Lys Ser Ser 
    530                 535                 540                 


Asp Xaa Xaa Lys Glu Ser Arg Pro Pro Asp Phe Ile Ser Ile Ser Ala 
545                 550                 555                 560 


Ser Lys Asn Ile Ser Gly Glu Xaa Pro Glu Gly Ile Lys Ala Glu Pro 
                565                 570                 575     


Leu Xaa Pro Met Glu Asp Ala Leu Pro Pro Ser Leu Ser Gly Gln Ala 
            580                 585                 590         


Lys Pro Glu Asp Ser Asp Cys His Arg Lys Ile Glu Xaa Cys Gly Ser 
        595                 600                 605             


Arg Lys Ser Glu Arg Ser Cys Lys Gly Ala Leu Tyr Lys Xaa Leu Val 
    610                 615                 620                 


Ser Glu Gly Met Leu Xaa Ser Leu Arg Ala Asn Val Asp Arg Gly Lys 
625                 630                 635                 640 


Arg Ser Ser Gly Lys Gly Asn Ser Ser Asp His Glu Gly Cys Trp Asn 
                645                 650                 655     


Glu Glu Ser Trp Xaa Phe Ser Gln Ser Gly Xaa Ser Gly Ser Lys Lys 
            660                 665                 670         


Phe Lys Lys Xaa Lys Pro Lys Glu Asp Cys Leu Leu Gly Ser Ala Lys 
        675                 680                 685             


Leu Asp Glu Glu Phe Glu Lys Lys Phe Asn Ser Leu Pro Gln Tyr Ser 
    690                 695                 700                 


Pro Val Xaa Phe Asp Arg Lys Cys Val Pro Val Pro Arg Lys Lys Lys 
705                 710                 715                 720 


Lys Xaa Gly Asn Val Ser Ser Glu Pro Xaa Lys Xaa Ser Lys Gly Ser 
                725                 730                 735     


Gly Asp Lys Trp Ser Asn Lys Gln Leu Phe Leu Asp Ala Ile His Pro 
            740                 745                 750         


Xaa Glu Ala Ile Phe Ser Glu Asp Arg Asn Xaa Met Glu Pro Val His 
        755                 760                 765             


Lys Val Lys Asn Ile Pro Ser Ile Phe Asn Xaa Pro Glu Pro Xaa Xaa 
    770                 775                 780                 


Xaa Gln Glu Pro Leu Val Gly Ser Gln Lys Arg Lys Ala Arg Lys Xaa 
785                 790                 795                 800 


Lys Ile Xaa His Leu Val Arg Xaa Ala Asp Gly Arg Val Ser Pro Ala 
                805                 810                 815     


Gly Gly Xaa Leu Asp Asp Lys Pro Lys Glu Gln Leu Gln Arg Ser Leu 
            820                 825                 830         


Pro Lys Ala Xaa Glu Xaa Asp Cys Asn Asp Lys Cys Ser His Asn Xaa 
        835                 840                 845             


Glu Val Gly Glu Xaa Arg Ser Ser Xaa Pro Glu Met Pro Ala Val Ser 
    850                 855                 860                 


Ala Phe Phe Ser Leu Ala Ala Leu Ala Glu Val Ala Ala Met Glu Asn 
865                 870                 875                 880 


Val His Arg Gly Gln Arg Ser Xaa Pro Leu Xaa His Asp Gly Gln Pro 
                885                 890                 895     


Lys Glu Met Pro Gln Ala Pro Val Leu Ile Ser Cys Ala Asp Gln 
            900                 905                 910     


<210> 4017
<211> 941
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<400> 4017
Met Lys Gly Ser Asn Arg Asn Lys Asp His Ser Ala Glu Gly Glu Gly 
1               5                   10                  15      


Val Gly Lys Arg Pro Lys Arg Lys Cys Leu Gln Trp His Pro Leu Leu 
            20                  25                  30          


Ala Lys Lys Leu Leu Asp Phe Ser Glu Glu Glu Glu Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Asp Ile Asp Lys Val Gln Leu Leu Gly Ala Asp Gly Leu Glu 
    50                  55                  60                  


Gln Asp Val Gly Glu Xaa Glu Asp Asp Glu Ser Pro Glu Gln Arg Ala 
65                  70                  75                  80  


Arg Arg Pro Met Asn Ala Phe Leu Leu Phe Cys Lys Arg His Arg Ser 
                85                  90                  95      


Leu Val Arg Gln Glu His Pro Arg Leu Asp Asn Arg Gly Ala Xaa Lys 
            100                 105                 110         


Ile Leu Ala Asp Trp Trp Ala Val Leu Asp Pro Lys Glu Lys Gln Lys 
        115                 120                 125             


Tyr Xaa Asp Met Ala Lys Glu Tyr Lys Asp Ala Phe Met Lys Ala Asn 
    130                 135                 140                 


Pro Gly Tyr Lys Trp Cys Pro Xaa Xaa Asn Lys Pro Val Lys Ser Pro 
145                 150                 155                 160 


Xaa Pro Xaa Val Asn Pro Arg Lys Lys Leu Trp Ala Phe Pro Ser Asp 
                165                 170                 175     


Ser Ser Arg Asp Leu Pro Ser Pro Lys Lys Ala Lys Xaa Glu Glu Met 
            180                 185                 190         


Pro Gln Leu Asn Phe Gly Met Ala Asp Pro Xaa Gln Met Gly Gly Leu 
        195                 200                 205             


Ser Met Leu Leu Leu Ala Gly Glu His Ala Leu Gly Xaa Pro Glu Val 
    210                 215                 220                 


Ser Ser Gly Xaa Cys Arg Pro Asp Val Ser Glu Ser Pro Glu Leu Arg 
225                 230                 235                 240 


Gln Lys Ser Pro Leu Phe Gln Phe Ala Glu Ile Ser Ser Ser Xaa Ser 
                245                 250                 255     


His Ser Asp Ala Ser Xaa Lys Gln Cys Gln Xaa Ser Ala Leu Phe Gln 
            260                 265                 270         


Phe Ala Glu Ile Ser Ser Asn Xaa Ser Gln Leu Gly Gly Ala Glu Pro 
        275                 280                 285             


Val Lys Arg Cys Gly Lys Ser Ala Leu Phe Gln Leu Ala Glu Met Cys 
    290                 295                 300                 


Leu Ala Ser Glu Gly Met Lys Met Glu Glu Ser Lys Leu Ile Lys Ala 
305                 310                 315                 320 


Lys Glu Ser Asp Gly Gly Arg Ile Lys Glu Leu Glu Lys Gly Lys Glu 
                325                 330                 335     


Glu Lys Glu Ile Lys Met Glu Lys Xaa Asp Glu Xaa Arg Leu Gln Lys 
            340                 345                 350         


Glu Ala Glu Phe Glu Lys Ser Ala Lys Glu Asn Leu Arg Asp Ser Lys 
        355                 360                 365             


Glu Leu Arg Asn Phe Glu Ala Leu Gln Ile Asp Asp Ile Met Ala Ile 
    370                 375                 380                 


Lys Met Glu Asp Pro Lys Glu Ile Arg Lys Glu Glu Leu Glu Glu Asp 
385                 390                 395                 400 


His Lys Cys Ser His Phe Pro Asp Phe Ser Tyr Ser Ala Ser Ser Lys 
                405                 410                 415     


Ile Ile Ile Ser Asp Val Pro Ser Arg Lys Asp His Met Cys His Pro 
            420                 425                 430         


His Gly Ile Met Ile Ile Glu Asp Pro Ala Ala Leu Asn Lys Pro Glu 
        435                 440                 445             


Lys Leu Lys Lys Lys Lys Lys Lys Ser Lys Met Asp Arg His Gly Asn 
    450                 455                 460                 


Asp Lys Ser Xaa Pro Lys Lys Xaa Cys Lys Lys Arg Gln Ser Ser Glu 
465                 470                 475                 480 


Ser Asp Ile Glu Ser Val Ile Tyr Xaa Ile Glu Ala Val Ala Lys Gly 
                485                 490                 495     


Asp Trp Gly Ile Glu Lys Leu Gly Asp Xaa Pro Arg Lys Lys Val Arg 
            500                 505                 510         


Xaa Ser Ser Ser Gly Lys Gly Ser Ile Leu Asp Ala Lys Pro Pro Lys 
        515                 520                 525             


Lys Lys Val Lys Ser Arg Glu Lys Lys Met Ser Lys Glu Lys Ser Ser 
    530                 535                 540                 


Asp Xaa Xaa Lys Glu Ser Arg Pro Pro Asp Phe Ile Ser Ile Ser Ala 
545                 550                 555                 560 


Ser Lys Asn Ile Ser Gly Glu Xaa Pro Glu Gly Ile Lys Ala Glu Pro 
                565                 570                 575     


Leu Xaa Pro Met Glu Asp Ala Leu Pro Pro Ser Leu Ser Gly Gln Ala 
            580                 585                 590         


Lys Pro Glu Asp Ser Asp Cys His Arg Lys Ile Glu Xaa Cys Gly Ser 
        595                 600                 605             


Arg Lys Ser Glu Arg Ser Cys Lys Gly Ala Leu Tyr Lys Xaa Leu Val 
    610                 615                 620                 


Ser Glu Gly Met Leu Xaa Ser Leu Arg Ala Asn Val Asp Arg Gly Lys 
625                 630                 635                 640 


Arg Ser Ser Gly Lys Gly Asn Ser Ser Asp His Glu Gly Cys Trp Asn 
                645                 650                 655     


Glu Glu Ser Trp Xaa Phe Ser Gln Ser Gly Xaa Ser Gly Ser Lys Lys 
            660                 665                 670         


Phe Lys Lys Xaa Lys Pro Lys Glu Asp Cys Leu Leu Gly Ser Ala Lys 
        675                 680                 685             


Leu Asp Glu Glu Phe Glu Lys Lys Phe Asn Ser Leu Pro Gln Tyr Ser 
    690                 695                 700                 


Pro Val Xaa Phe Asp Arg Lys Cys Val Pro Val Pro Arg Lys Lys Lys 
705                 710                 715                 720 


Lys Xaa Gly Asn Val Ser Ser Glu Pro Xaa Lys Xaa Ser Lys Gly Pro 
                725                 730                 735     


Phe Gln Ser Gln Lys Lys Asn Leu Phe His Lys Ile Val Ser Lys Tyr 
            740                 745                 750         


Lys His Lys Lys Glu Lys Pro Asn Val Pro Glu Lys Gly Ser Gly Asp 
        755                 760                 765             


Lys Trp Ser Asn Lys Gln Leu Phe Leu Asp Ala Ile His Pro Xaa Glu 
    770                 775                 780                 


Ala Ile Phe Ser Glu Asp Arg Asn Xaa Met Glu Pro Val His Lys Val 
785                 790                 795                 800 


Lys Asn Ile Pro Ser Ile Phe Asn Xaa Pro Glu Pro Xaa Xaa Xaa Gln 
                805                 810                 815     


Glu Pro Leu Val Gly Ser Gln Lys Arg Lys Ala Arg Lys Xaa Lys Ile 
            820                 825                 830         


Xaa His Leu Val Arg Xaa Ala Asp Gly Arg Val Ser Pro Ala Gly Gly 
        835                 840                 845             


Xaa Leu Asp Asp Lys Pro Lys Glu Gln Leu Gln Arg Ser Leu Pro Lys 
    850                 855                 860                 


Ala Xaa Glu Xaa Asp Cys Asn Asp Lys Cys Ser His Asn Xaa Glu Val 
865                 870                 875                 880 


Gly Glu Xaa Arg Ser Ser Xaa Pro Glu Met Pro Ala Val Ser Ala Phe 
                885                 890                 895     


Phe Ser Leu Ala Ala Leu Ala Glu Val Ala Ala Met Glu Asn Val His 
            900                 905                 910         


Arg Gly Gln Arg Ser Xaa Pro Leu Xaa His Asp Gly Gln Pro Lys Glu 
        915                 920                 925             


Met Pro Gln Ala Pro Val Leu Ile Ser Cys Ala Asp Gln 
    930                 935                 940     


<210> 4018
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 4018
Asn Xaa Pro Glu Pro Xaa Xaa Xaa Gln Glu Pro Leu Val Gly Ser Gln 
1               5                   10                  15      


Lys Arg Lys Ala Arg Lys Xaa Lys Ile Xaa His Leu Val Arg Xaa Ala 
            20                  25                  30          


Asp Gly Arg Val Ser Pro Ala Gly Asp Asp Lys Pro Lys Glu Gln Leu 
        35                  40                  45              


Gln Arg Ser Leu Pro Lys Ala Xaa Glu Xaa Asp Cys Asn Asp Lys Cys 
    50                  55                  60                  


Ser His Asn Xaa Glu Val Gly Glu Xaa Arg Ser Ser Xaa Pro Glu Met 
65                  70                  75                  80  


Pro Ala Val Ser Ala Phe Phe Ser Leu Ala Ala Leu Ala Glu Val Ala 
                85                  90                  95      


Ala Met Glu Asn Val His Arg Gly Gln Arg Ser Xaa Pro Leu Xaa His 
            100                 105                 110         


Asp Gly Gln Pro Lys Glu Met Pro Gln Ala Pro Val Leu Ile Ser Cys 
        115                 120                 125             


Ala Asp Gln 
    130     


<210> 4019
<211> 80
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<400> 4019
Xaa Xaa Lys Xaa Ser Lys Gly Pro Phe Gln Ser Gln Lys Lys Asn Leu 
1               5                   10                  15      


Phe His Lys Ile Val Ser Lys Tyr Lys His Lys Lys Glu Lys Pro Asn 
            20                  25                  30          


Val Pro Glu Lys Gly Ser Gly Asp Lys Trp Ser Asn Lys Gln Leu Phe 
        35                  40                  45              


Leu Asp Ala Ile His Pro Xaa Glu Glu Pro Xaa Xaa Xaa Gln Glu Pro 
    50                  55                  60                  


Leu Val Gly Ser Gln Lys Arg Lys Ala Arg Lys Xaa Lys Ile Xaa His 
65                  70                  75                  80  


<210> 4020
<211> 588
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<400> 4020
Met Glu Pro Pro Asp Ala Pro Ala Gln Ala Arg Gly Ala Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Ala Val Leu Leu Ala Ala His Pro Asp Ala Gln Ala Glu 
            20                  25                  30          


Val Arg Leu Ser Val Pro Pro Leu Val Glu Val Met Arg Gly Lys Ser 
        35                  40                  45              


Val Ile Leu Asp Cys Xaa Pro Xaa Gly Xaa His Asp His Tyr Met Leu 
    50                  55                  60                  


Glu Trp Phe Leu Xaa Asp Arg Ser Gly Ala Arg Pro Arg Leu Ala Ser 
65                  70                  75                  80  


Ala Glu Met Gln Gly Ser Glu Leu Gln Val Xaa Met His Asp Xaa Arg 
                85                  90                  95      


Gly Arg Ser Pro Pro Tyr Gln Leu Asp Ser Gln Gly Arg Leu Val Leu 
            100                 105                 110         


Ala Glu Ala Gln Val Gly Asp Glu Arg Asp Tyr Val Cys Val Val Arg 
        115                 120                 125             


Ala Gly Ala Ala Gly Xaa Ala Glu Ala Xaa Ala Arg Leu Asn Val Phe 
    130                 135                 140                 


Ala Lys Pro Glu Ala Xaa Glu Val Ser Pro Asn Lys Gly Xaa Leu Ser 
145                 150                 155                 160 


Val Met Glu Asp Ser Ala Gln Glu Ile Ala Xaa Cys Asn Ser Arg Asn 
                165                 170                 175     


Gly Asn Pro Ala Pro Lys Ile Xaa Trp Tyr Arg Asn Gly Gln Arg Leu 
            180                 185                 190         


Glu Val Pro Val Glu Met Asn Pro Glu Gly Tyr Met Xaa Ser Arg Xaa 
        195                 200                 205             


Val Arg Glu Ala Ser Gly Leu Leu Ser Leu Xaa Ser Xaa Leu Tyr Leu 
    210                 215                 220                 


Arg Leu Arg Lys Asp Asp Arg Asp Ala Ser Phe His Cys Ala Ala His 
225                 230                 235                 240 


Tyr Ser Leu Pro Glu Gly Arg His Gly Arg Leu Asp Ser Pro Xaa Phe 
                245                 250                 255     


His Leu Xaa Leu His Tyr Pro Xaa Glu His Val Gln Phe Trp Val Gly 
            260                 265                 270         


Ser Pro Ser Xaa Pro Ala Gly Trp Val Arg Glu Gly Asp Xaa Val Gln 
        275                 280                 285             


Leu Leu Cys Arg Gly Asp Gly Ser Pro Ser Pro Glu Tyr Xaa Leu Phe 
    290                 295                 300                 


Arg Leu Gln Asp Glu Gln Glu Glu Val Leu Asn Val Asn Leu Glu Gly 
305                 310                 315                 320 


Asn Leu Xaa Leu Glu Gly Val Xaa Arg Gly Gln Ser Gly Xaa Tyr Gly 
                325                 330                 335     


Cys Arg Val Glu Asp Tyr Asp Ala Ala Asp Asp Val Gln Leu Ser Lys 
            340                 345                 350         


Xaa Leu Glu Leu Arg Val Ala Tyr Leu Asp Pro Leu Glu Leu Ser Glu 
        355                 360                 365             


Gly Lys Val Leu Ser Leu Pro Leu Asn Ser Ser Ala Val Val Asn Cys 
    370                 375                 380                 


Ser Val His Gly Leu Pro Xaa Pro Ala Leu Arg Trp Xaa Lys Asp Ser 
385                 390                 395                 400 


Xaa Pro Leu Gly Asp Gly Pro Met Leu Ser Leu Ser Ser Ile Xaa Phe 
                405                 410                 415     


Asp Ser Asn Gly Xaa Tyr Val Cys Glu Ala Ser Leu Pro Xaa Val Pro 
            420                 425                 430         


Val Leu Ser Arg Xaa Gln Asn Phe Xaa Leu Leu Val Gln Gly Ser Pro 
        435                 440                 445             


Glu Leu Lys Xaa Ala Glu Ile Glu Pro Lys Ala Asp Gly Ser Trp Arg 
    450                 455                 460                 


Glu Gly Asp Glu Val Xaa Leu Ile Cys Ser Ala Arg Gly His Pro Asp 
465                 470                 475                 480 


Pro Lys Leu Ser Trp Ser Gln Leu Gly Gly Ser Pro Ala Glu Pro Ile 
                485                 490                 495     


Pro Gly Arg Gln Gly Trp Val Ser Ser Ser Leu Xaa Leu Lys Val Xaa 
            500                 505                 510         


Ser Ala Leu Ser Arg Asp Gly Ile Ser Cys Glu Ala Ser Asn Pro His 
        515                 520                 525             


Gly Asn Lys Arg His Val Phe His Phe Gly Xaa Val Ser Pro Gln Xaa 
    530                 535                 540                 


Ser Gln Ala Gly Val Ala Val Met Ala Val Ala Val Ser Val Gly Leu 
545                 550                 555                 560 


Leu Leu Leu Val Val Ala Val Phe Tyr Cys Val Arg Arg Lys Gly Gly 
                565                 570                 575     


Pro Cys Cys Arg Gln Arg Arg Glu Lys Gly Ala Pro 
            580                 585             


<210> 4021
<211> 628
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<400> 4021
Met Glu Pro Pro Asp Ala Pro Ala Gln Ala Arg Gly Ala Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Ala Val Leu Leu Ala Ala His Pro Asp Ala Gln Ala Glu 
            20                  25                  30          


Val Arg Leu Ser Val Pro Pro Leu Val Glu Val Met Arg Gly Lys Ser 
        35                  40                  45              


Val Ile Leu Asp Cys Xaa Pro Xaa Gly Xaa His Asp His Tyr Met Leu 
    50                  55                  60                  


Glu Trp Phe Leu Xaa Asp Arg Ser Gly Ala Arg Pro Arg Leu Ala Ser 
65                  70                  75                  80  


Ala Glu Met Gln Gly Ser Glu Leu Gln Val Xaa Met His Asp Xaa Arg 
                85                  90                  95      


Gly Arg Ser Pro Pro Tyr Gln Leu Asp Ser Gln Gly Arg Leu Val Leu 
            100                 105                 110         


Ala Glu Ala Gln Val Gly Asp Glu Arg Asp Tyr Val Cys Val Val Arg 
        115                 120                 125             


Ala Gly Ala Ala Gly Xaa Ala Glu Ala Xaa Ala Arg Leu Asn Val Phe 
    130                 135                 140                 


Ala Lys Pro Glu Ala Xaa Glu Val Ser Pro Asn Lys Gly Xaa Leu Ser 
145                 150                 155                 160 


Val Met Glu Asp Ser Ala Gln Glu Ile Ala Xaa Cys Asn Ser Arg Asn 
                165                 170                 175     


Gly Asn Pro Ala Pro Lys Ile Xaa Trp Tyr Arg Asn Gly Gln Arg Leu 
            180                 185                 190         


Glu Val Pro Val Glu Met Asn Pro Glu Gly Tyr Met Xaa Ser Arg Xaa 
        195                 200                 205             


Val Arg Glu Ala Ser Gly Leu Leu Ser Leu Xaa Ser Xaa Leu Tyr Leu 
    210                 215                 220                 


Arg Leu Arg Lys Asp Asp Arg Asp Ala Ser Phe His Cys Ala Ala His 
225                 230                 235                 240 


Tyr Ser Leu Pro Glu Gly Arg His Gly Arg Leu Asp Ser Pro Xaa Phe 
                245                 250                 255     


His Leu Xaa Leu His Tyr Pro Xaa Glu His Val Gln Phe Trp Val Gly 
            260                 265                 270         


Ser Pro Ser Xaa Pro Ala Gly Trp Val Arg Glu Gly Asp Xaa Val Gln 
        275                 280                 285             


Leu Leu Cys Arg Gly Asp Gly Ser Pro Ser Pro Glu Tyr Xaa Leu Phe 
    290                 295                 300                 


Arg Leu Gln Asp Glu Gln Glu Glu Val Leu Asn Val Asn Leu Glu Gly 
305                 310                 315                 320 


Asn Leu Xaa Leu Glu Gly Val Xaa Arg Gly Gln Ser Gly Xaa Tyr Gly 
                325                 330                 335     


Cys Arg Val Glu Asp Tyr Asp Ala Ala Asp Asp Val Gln Leu Ser Lys 
            340                 345                 350         


Xaa Leu Glu Leu Arg Val Ala Tyr Leu Asp Pro Leu Glu Leu Ser Glu 
        355                 360                 365             


Gly Lys Val Leu Ser Leu Pro Leu Asn Ser Ser Ala Val Val Asn Cys 
    370                 375                 380                 


Ser Val His Gly Leu Pro Xaa Pro Ala Leu Arg Trp Xaa Lys Asp Ser 
385                 390                 395                 400 


Xaa Pro Leu Gly Asp Gly Pro Met Leu Ser Leu Ser Ser Ile Xaa Phe 
                405                 410                 415     


Asp Ser Asn Gly Xaa Tyr Val Cys Glu Ala Ser Leu Pro Xaa Val Pro 
            420                 425                 430         


Val Leu Ser Arg Xaa Gln Asn Phe Xaa Leu Leu Val Gln Gly Ser Pro 
        435                 440                 445             


Glu Leu Lys Xaa Ala Glu Ile Glu Pro Lys Ala Asp Gly Ser Trp Arg 
    450                 455                 460                 


Glu Gly Asp Glu Val Xaa Leu Ile Cys Ser Ala Arg Gly His Pro Asp 
465                 470                 475                 480 


Pro Lys Leu Ser Trp Ser Gln Leu Gly Gly Ser Pro Ala Glu Pro Ile 
                485                 490                 495     


Pro Gly Arg Gln Gly Trp Val Ser Ser Ser Leu Xaa Leu Lys Val Xaa 
            500                 505                 510         


Ser Ala Leu Ser Arg Asp Gly Ile Ser Cys Glu Ala Ser Asn Pro His 
        515                 520                 525             


Gly Asn Lys Arg His Val Phe His Phe Gly Xaa Val Ser Pro Gln Xaa 
    530                 535                 540                 


Ser Gln Ala Gly Val Ala Val Met Ala Val Ala Val Ser Val Gly Leu 
545                 550                 555                 560 


Leu Leu Leu Val Val Ala Val Phe Tyr Cys Val Arg Arg Lys Gly Gly 
                565                 570                 575     


Pro Cys Cys Arg Gln Arg Arg Glu Lys Gly Ala Pro Pro Pro Gly Glu 
            580                 585                 590         


Pro Gly Leu Ser His Ser Gly Ser Glu Gln Pro Glu Gln Xaa Gly Leu 
        595                 600                 605             


Leu Met Gly Gly Ala Ser Gly Gly Ala Arg Gly Gly Ser Gly Gly Phe 
    610                 615                 620                 


Gly Asp Glu Cys 
625             


<210> 4022
<211> 291
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<400> 4022
Met Glu Pro Pro Asp Ala Pro Ala Gln Ala Arg Gly Ala Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Ala Val Leu Leu Ala Ala His Pro Asp Ala Gln Ala Glu 
            20                  25                  30          


Val Arg Leu Ser Val Pro Pro Leu Val Glu Val Met Arg Gly Lys Ser 
        35                  40                  45              


Val Ile Leu Asp Cys Xaa Pro Xaa Gly Xaa His Asp His Tyr Met Leu 
    50                  55                  60                  


Glu Trp Phe Leu Val Xaa Met His Asp Xaa Arg Gly Arg Ser Pro Pro 
65                  70                  75                  80  


Tyr Gln Leu Asp Ser Gln Gly Arg Leu Val Leu Ala Glu Ala Gln Val 
                85                  90                  95      


Gly Asp Glu Arg Asp Tyr Val Cys Val Val Arg Ala Gly Ala Ala Gly 
            100                 105                 110         


Xaa Ala Glu Ala Xaa Ala Arg Leu Asn Val Phe Ala Lys Pro Glu Ala 
        115                 120                 125             


Xaa Glu Val Ser Pro Asn Lys Gly Xaa Leu Ser Val Met Glu Asp Ser 
    130                 135                 140                 


Ala Gln Glu Ile Ala Xaa Cys Asn Ser Arg Asn Gly Asn Pro Ala Pro 
145                 150                 155                 160 


Lys Ile Xaa Trp Tyr Arg Asn Gly Gln Arg Leu Glu Val Pro Val Glu 
                165                 170                 175     


Met Asn Pro Glu Gly Tyr Met Xaa Ser Arg Xaa Val Arg Glu Ala Ser 
            180                 185                 190         


Gly Leu Leu Ser Leu Xaa Ser Xaa Leu Tyr Leu Arg Leu Arg Lys Asp 
        195                 200                 205             


Asp Arg Asp Ala Ser Phe His Cys Ala Ala His Tyr Ser Leu Pro Glu 
    210                 215                 220                 


Gly Arg His Gly Arg Leu Asp Ser Pro Xaa Phe His Leu Xaa Leu His 
225                 230                 235                 240 


Tyr Pro Xaa Glu His Val Gln Phe Trp Val Gly Ser Pro Ser Xaa Pro 
                245                 250                 255     


Ala Gly Trp Val Arg Glu Gly Asp Xaa Val Gln Leu Leu Cys Arg Gly 
            260                 265                 270         


Asp Gly Ser Pro Ser Pro Glu Tyr Xaa Leu Phe Arg Leu Gln Val Xaa 
        275                 280                 285             


His Pro Arg 
    290     


<210> 4023
<211> 61
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<400> 4023
Xaa Gly Tyr Met Xaa Ser Arg Xaa Val Arg Glu Ala Ser Gly Leu Leu 
1               5                   10                  15      


Ser Leu Xaa Ser Xaa Leu Tyr Leu Arg Leu Arg Lys Asp Asp Arg Asp 
            20                  25                  30          


Ala Ser Phe His Cys Ala Ala His Tyr Ser Leu Pro Glu Gly Arg His 
        35                  40                  45              


Gly Arg Leu Asp Ser Pro Xaa Phe His Leu Xaa Leu His 
    50                  55                  60      


<210> 4024
<211> 313
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<400> 4024
Met Gly Ala Glu Ala Ser Ser Ser Trp Cys Pro Gly Xaa Ala Leu Pro 
1               5                   10                  15      


Glu Glu Arg Leu Ser Val Lys Arg Ala Ser Glu Ile Ser Gly Phe Leu 
            20                  25                  30          


Gly Gln Gly Ser Ser Gly Glu Ala Ala Leu Asp Val Leu Xaa His Val 
        35                  40                  45              


Leu Glu Gly Ala Gly Asn Lys Leu Xaa Ser Ser Cys Gly Lys Pro Ser 
    50                  55                  60                  


Ser Asn Arg Met Ser Leu Gln Trp Xaa Ala Val Ala Xaa Phe Leu Tyr 
65                  70                  75                  80  


Ala Glu Val Phe Val Val Leu Leu Leu Cys Ile Pro Phe Ile Ser Pro 
                85                  90                  95      


Lys Arg Trp Gln Lys Ile Phe Lys Ser Arg Leu Val Glu Leu Leu Val 
            100                 105                 110         


Ser Tyr Gly Asn Xaa Phe Phe Val Val Leu Ile Val Ile Leu Val Leu 
        115                 120                 125             


Leu Val Ile Asp Ala Val Arg Glu Ile Arg Lys Tyr Asp Asp Val Xaa 
    130                 135                 140                 


Glu Lys Val Asn Leu Gln Asn Asn Pro Gly Ala Met Glu His Phe His 
145                 150                 155                 160 


Met Lys Leu Phe Arg Ala Gln Arg Asn Leu Tyr Ile Ala Gly Phe Ser 
                165                 170                 175     


Leu Leu Leu Ser Phe Leu Leu Arg Arg Leu Val Xaa Leu Ile Ser Gln 
            180                 185                 190         


Gln Ala Xaa Leu Leu Ala Ser Asn Glu Ala Phe Lys Lys Gln Ala Glu 
        195                 200                 205             


Ser Ala Ser Glu Ala Ala Lys Lys Tyr Met Glu Glu Asn Asp Gln Leu 
    210                 215                 220                 


Lys Lys Gly Ala Ala Val Asp Gly Gly Lys Leu Asp Val Gly Asn Ala 
225                 230                 235                 240 


Glu Val Lys Leu Glu Glu Glu Asn Arg Ser Leu Lys Ala Asp Leu Gln 
                245                 250                 255     


Lys Leu Lys Asp Glu Leu Ala Ser Xaa Lys Gln Lys Leu Glu Lys Ala 
            260                 265                 270         


Glu Asn Gln Val Leu Ala Met Arg Lys Gln Ser Glu Gly Leu Xaa Lys 
        275                 280                 285             


Glu Tyr Asp Arg Leu Leu Glu Glu His Ala Lys Leu Gln Ala Ala Val 
    290                 295                 300                 


Asp Gly Pro Met Asp Lys Lys Glu Glu 
305                 310             


<210> 4025
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 4025
Met Ser Leu Gln Trp Xaa Ala Val Ala Xaa Phe Leu Tyr Ala Glu Val 
1               5                   10                  15      


Phe Val Val Leu Leu Leu Cys Ile Pro Phe Ile Ser Pro Lys Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Lys Ser Arg Leu Val Glu Leu Leu Val Ser Tyr Gly 
        35                  40                  45              


Asn Xaa Phe Phe Val Val Leu Ile Val Ile Leu Val Leu Leu Val Ile 
    50                  55                  60                  


Asp Ala Val Arg Glu Ile Arg Lys Tyr Asp Asp Val Xaa Glu Lys Val 
65                  70                  75                  80  


Asn Leu Gln Asn Asn Pro Gly Ala Met Glu His Phe His Met Lys Leu 
                85                  90                  95      


Phe Arg Ala Gln Arg Asn Leu Tyr Ile Ala Gly Phe Ser Leu Leu Leu 
            100                 105                 110         


Ser Phe Leu Leu Arg Arg Leu Val Xaa Leu Ile Ser Gln Gln Ala Xaa 
        115                 120                 125             


Leu Leu Ala Ser Asn Glu Ala Phe Lys Lys 
    130                 135             


<210> 4026
<211> 178
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 4026
Met Ser Leu Gln Trp Xaa Ala Val Ala Xaa Phe Leu Tyr Ala Glu Val 
1               5                   10                  15      


Phe Val Val Leu Leu Leu Cys Ile Pro Phe Ile Ser Pro Lys Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Lys Ser Arg Leu Val Glu Leu Leu Val Ser Tyr Gly 
        35                  40                  45              


Asn Xaa Phe Phe Val Val Leu Ile Val Ile Leu Val Leu Leu Val Ile 
    50                  55                  60                  


Asp Ala Val Arg Glu Ile Arg Lys Tyr Asp Asp Val Xaa Glu Lys Val 
65                  70                  75                  80  


Asn Leu Gln Asn Asn Pro Gly Ala Met Glu His Phe His Met Lys Leu 
                85                  90                  95      


Phe Arg Ala Gln Arg Asn Leu Tyr Ile Ala Gly Phe Ser Leu Leu Leu 
            100                 105                 110         


Ser Phe Leu Leu Arg Arg Leu Val Xaa Leu Ile Ser Gln Gln Ala Xaa 
        115                 120                 125             


Leu Leu Ala Ser Asn Glu Ala Phe Lys Lys Gln Ala Glu Ser Ala Ser 
    130                 135                 140                 


Glu Ala Ala Lys Lys Tyr Met Glu Glu Asn Asp Gln Leu Lys Lys Gly 
145                 150                 155                 160 


Ala Ala Val Asp Gly Gly Lys Leu Asp Val Gly Asn Ala Glu Val Lys 
                165                 170                 175     


Leu Glu 
        


<210> 4027
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 4027
Met Ser Leu Gln Trp Xaa Ala Val Ala Xaa Phe Leu Tyr Ala Glu Val 
1               5                   10                  15      


Phe Val Val Leu Leu Leu Cys Ile Pro Phe Ile Ser Pro Lys Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Lys Ser Arg Leu Val Glu Leu Leu Val Ser Tyr Gly 
        35                  40                  45              


Asn Xaa Phe Phe Val Val Leu Ile Val Ile Leu Val Leu Leu Val Ile 
    50                  55                  60                  


Asp Ala Val Arg Glu Ile Arg Lys Tyr Asp Asp Val Xaa Glu Lys Val 
65                  70                  75                  80  


Asn Leu Gln Asn Asn Pro Gly Ala Met Glu His Phe His Met Lys Leu 
                85                  90                  95      


Phe Arg Ala Gln Arg Asn Leu Tyr Ile Ala Gly Phe Ser Leu Leu Leu 
            100                 105                 110         


Ser Phe Leu Leu Arg Arg Leu Val Xaa Leu Ile Ser Gln Gln Ala Xaa 
        115                 120                 125             


Leu Leu Ala Ser Asn Glu Ala Phe Lys Lys Gln Ala Glu Ser Ala Ser 
    130                 135                 140                 


Glu Ala Ala Lys Lys Tyr Met Glu Glu Asn Asp Gln Leu Lys Lys Gly 
145                 150                 155                 160 


Ala Ala Val Asp Gly Gly Lys Leu Asp Val Gly Asn Ala Glu Val Lys 
                165                 170                 175     


Leu Glu Glu Glu Asn Arg 
            180         


<210> 4028
<211> 187
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 4028
Met Ser Leu Gln Trp Xaa Ala Val Ala Xaa Phe Leu Tyr Ala Glu Val 
1               5                   10                  15      


Phe Val Val Leu Leu Leu Cys Ile Pro Phe Ile Ser Pro Lys Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Lys Ser Arg Leu Val Glu Leu Leu Val Ser Tyr Gly 
        35                  40                  45              


Asn Xaa Phe Phe Val Val Leu Ile Val Ile Leu Val Leu Leu Val Ile 
    50                  55                  60                  


Asp Ala Val Arg Glu Ile Arg Lys Tyr Asp Asp Val Xaa Glu Lys Val 
65                  70                  75                  80  


Asn Leu Gln Asn Asn Pro Gly Ala Met Glu His Phe His Met Lys Leu 
                85                  90                  95      


Phe Arg Ala Gln Arg Asn Leu Tyr Ile Ala Gly Phe Ser Leu Leu Leu 
            100                 105                 110         


Ser Phe Leu Leu Arg Arg Leu Val Xaa Leu Ile Ser Gln Gln Ala Xaa 
        115                 120                 125             


Leu Leu Ala Ser Asn Glu Ala Phe Lys Lys Gln Ala Glu Ser Ala Ser 
    130                 135                 140                 


Glu Ala Ala Lys Lys Tyr Met Glu Glu Asn Asp Gln Leu Lys Lys Gly 
145                 150                 155                 160 


Ala Ala Val Asp Gly Gly Lys Leu Asp Val Gly Asn Ala Glu Val Lys 
                165                 170                 175     


Leu Glu Glu Glu Asn Arg Ser Leu Lys Ala Asp 
            180                 185         


<210> 4029
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 4029
Met Ser Leu Gln Trp Xaa Ala Val Ala Xaa Phe Leu Tyr Ala Glu Val 
1               5                   10                  15      


Phe Val Val Leu Leu Leu Cys Ile Pro Phe Ile Ser Pro Lys Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Lys Ser Arg Leu Val Glu Leu Leu Val Ser Tyr Gly 
        35                  40                  45              


Asn Xaa Phe Phe Val Val Leu Ile Val Ile Leu Val Leu Leu Val Ile 
    50                  55                  60                  


Asp Ala Val Arg Glu Ile Arg Lys Tyr Asp Asp Val Xaa Glu Lys Val 
65                  70                  75                  80  


Asn Leu Gln Asn Asn Pro Gly Ala Met Glu His Phe His Met Lys Leu 
                85                  90                  95      


Phe Arg Ala Gln Arg Asn Leu Tyr Ile Ala Gly Phe Ser Leu Leu Leu 
            100                 105                 110         


Ser Phe Leu Leu Arg Arg Leu Val Xaa Leu Ile Ser Gln Gln Ala Xaa 
        115                 120                 125             


Leu Leu Ala Ser Asn Glu Ala Phe Lys Lys Gln Ala Glu Ser Ala Ser 
    130                 135                 140                 


Glu Ala Ala Lys Lys Tyr Met Glu Glu Asn Asp Gln Leu Lys Lys Gly 
145                 150                 155                 160 


Ala Ala Val Asp Gly Gly Lys Leu Asp Val Gly Asn Ala Glu Val Lys 
                165                 170                 175     


Leu Glu Glu Glu Asn Arg Ser Leu Lys Ala Asp Leu 
            180                 185             


<210> 4030
<211> 246
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<400> 4030
Met Ser Leu Gln Trp Xaa Ala Val Ala Xaa Phe Leu Tyr Ala Glu Val 
1               5                   10                  15      


Phe Val Val Leu Leu Leu Cys Ile Pro Phe Ile Ser Pro Lys Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Lys Ser Arg Leu Val Glu Leu Leu Val Ser Tyr Gly 
        35                  40                  45              


Asn Xaa Phe Phe Val Val Leu Ile Val Ile Leu Val Leu Leu Val Ile 
    50                  55                  60                  


Asp Ala Val Arg Glu Ile Arg Lys Tyr Asp Asp Val Xaa Glu Lys Val 
65                  70                  75                  80  


Asn Leu Gln Asn Asn Pro Gly Ala Met Glu His Phe His Met Lys Leu 
                85                  90                  95      


Phe Arg Ala Gln Arg Asn Leu Tyr Ile Ala Gly Phe Ser Leu Leu Leu 
            100                 105                 110         


Ser Phe Leu Leu Arg Arg Leu Val Xaa Leu Ile Ser Gln Gln Ala Xaa 
        115                 120                 125             


Leu Leu Ala Ser Asn Glu Ala Phe Lys Lys Gln Ala Glu Ser Ala Ser 
    130                 135                 140                 


Glu Ala Ala Lys Lys Tyr Met Glu Glu Asn Asp Gln Leu Lys Lys Gly 
145                 150                 155                 160 


Ala Ala Val Asp Gly Gly Lys Leu Asp Val Gly Asn Ala Glu Val Lys 
                165                 170                 175     


Leu Glu Glu Glu Asn Arg Ser Leu Lys Ala Asp Leu Gln Lys Leu Lys 
            180                 185                 190         


Asp Glu Leu Ala Ser Xaa Lys Gln Lys Leu Glu Lys Ala Glu Asn Gln 
        195                 200                 205             


Val Leu Ala Met Arg Lys Gln Ser Glu Gly Leu Xaa Lys Glu Tyr Asp 
    210                 215                 220                 


Arg Leu Leu Glu Glu His Ala Lys Leu Gln Ala Ala Val Asp Gly Pro 
225                 230                 235                 240 


Met Asp Lys Lys Glu Glu 
                245     


<210> 4031
<211> 868
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<400> 4031
Met Glu Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala Glu Ser 
1               5                   10                  15      


Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Xaa Val Leu Glu 
            20                  25                  30          


Gln Asp Xaa Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu His Gly 
        35                  40                  45              


Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val Gly Met 
    50                  55                  60                  


Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly Pro Pro Ala Xaa Pro 
65                  70                  75                  80  


Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro Pro Ala Ser Gln 
                85                  90                  95      


Tyr Xaa Pro Met Leu Pro Asn Xaa Tyr Gln Pro Gln Pro Asp Ser Val 
            100                 105                 110         


Tyr Leu Val Pro Xaa Pro Ser Lys Ala Gln Gln Gly Leu Tyr Gln Val 
        115                 120                 125             


Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala Lys Gln Xaa Ser 
    130                 135                 140                 


Xaa Phe Ser Lys Gln Xaa Pro His His Pro Phe Pro Ser Pro Ala Xaa 
145                 150                 155                 160 


Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro Ala Gln Asp Ile 
                165                 170                 175     


Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp Ile Tyr Gln Val 
            180                 185                 190         


Pro Pro Ser Met Asp Xaa Arg Ser Trp Glu Gly Xaa Lys Pro Pro Ala 
        195                 200                 205             


Lys Val Val Val Pro Xaa Arg Val Gly Gln Gly Tyr Val Tyr Glu Ala 
    210                 215                 220                 


Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg His Leu Leu Ala 
225                 230                 235                 240 


Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly Leu Leu 
                245                 250                 255     


Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Xaa Pro Pro Met Ala Val 
            260                 265                 270         


Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr Asp Val Pro 
        275                 280                 285             


Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His His Ala Val Tyr 
    290                 295                 300                 


Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp Gly Pro Leu Leu 
305                 310                 315                 320 


Arg Glu Glu Xaa Tyr Asp Val Pro Pro Ala Phe Ala Lys Ala Lys Pro 
                325                 330                 335     


Phe Asp Pro Ala Arg Xaa Pro Leu Val Leu Ala Ala Pro Pro Pro Asp 
            340                 345                 350         


Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro Pro Ala Pro Asp 
        355                 360                 365             


Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly Pro Gly Xaa Leu 
    370                 375                 380                 


Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu Val Ala Asp Gly 
385                 390                 395                 400 


Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro Pro Ala Glu Arg 
                405                 410                 415     


Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser Ser Xaa Gly Ser 
            420                 425                 430         


Xaa Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val Ala Gly Pro Gly 
        435                 440                 445             


Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala Leu Ala Arg Leu 
    450                 455                 460                 


Gln Gln Gly Val Ser Ala Xaa Val Ala His Leu Leu Asp Leu Ala Gly 
465                 470                 475                 480 


Ser Ala Gly Ala Xaa Gly Ser Trp Arg Ser Pro Ser Glu Pro Gln Glu 
                485                 490                 495     


Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala Val Gln Ser Ala 
            500                 505                 510         


Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val Gly Asn Ala Ala 
        515                 520                 525             


His Xaa Ser Asp Arg Ala Leu His Ala Lys Leu Ser Arg Gln Leu Gln 
    530                 535                 540                 


Lys Met Glu Asp Val His Gln Xaa Leu Val Ala His Gly Gln Ala Leu 
545                 550                 555                 560 


Asp Ala Gly Arg Gly Gly Ser Gly Ala Xaa Leu Glu Asp Leu Asp Arg 
                565                 570                 575     


Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala Lys Gln Leu Ala 
            580                 585                 590         


Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg Arg Xaa Lys Ala 
        595                 600                 605             


Xaa Ala Pro Gly Pro Glu Gly Gly Gly Xaa Leu His Pro Asn Pro Xaa 
    610                 615                 620                 


Asp Lys Xaa Ser Ser Ile Gln Ser Arg Pro Leu Pro Ser Pro Pro Lys 
625                 630                 635                 640 


Phe Xaa Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu Asn Ser Glu Gly 
                645                 650                 655     


Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln Gly Lys Glu Glu 
            660                 665                 670         


Phe Glu Lys Xaa Gln Lys Glu Leu Leu Glu Lys Gly Ser Ile Xaa Arg 
        675                 680                 685             


Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys Gln Phe Glu Arg 
    690                 695                 700                 


Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp Leu Ala Asn Trp 
705                 710                 715                 720 


Xaa Pro Ala Gln Pro Leu Ala Pro Gly Arg Xaa Gly Gly Leu Gly Pro 
                725                 730                 735     


Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln Cys Glu Ala Asn 
            740                 745                 750         


Leu Xaa Xaa Leu Xaa Asn Ala Val Asp Ala Phe Phe Xaa Ala Val Ala 
        755                 760                 765             


Xaa Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser Lys Phe Val Ile 
    770                 775                 780                 


Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Xaa Leu Ser Arg Gln 
785                 790                 795                 800 


Ala Lys Ala Ala Asp Val Arg Ser Gln Val Xaa His Tyr Ser Asn Leu 
                805                 810                 815     


Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Xaa Xaa Lys Ala Ala Ala 
            820                 825                 830         


Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met Val Glu Arg Val 
        835                 840                 845             


Lys Glu Leu Gly His Ser Xaa Gln Gln Phe Arg Arg Val Leu Gly Gln 
    850                 855                 860                 


Leu Ala Ala Ala 
865             


<210> 4032
<211> 888
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<400> 4032
Met His Cys Pro Gly Glu Ala Pro Leu Ala Ala Pro Arg Pro Xaa Pro 
1               5                   10                  15      


Lys Asp Pro Cys Leu Arg Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn 
            20                  25                  30          


Val Ala Glu Ser Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met 
        35                  40                  45              


Xaa Val Leu Glu Gln Asp Xaa Gln Gly Leu Asp Gly Trp Trp Leu Cys 
    50                  55                  60                  


Ser Leu His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile 
65                  70                  75                  80  


Leu Val Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly Pro 
                85                  90                  95      


Pro Ala Xaa Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro 
            100                 105                 110         


Pro Ala Ser Gln Tyr Xaa Pro Met Leu Pro Asn Xaa Tyr Gln Pro Gln 
        115                 120                 125             


Pro Asp Ser Val Tyr Leu Val Pro Xaa Pro Ser Lys Ala Gln Gln Gly 
    130                 135                 140                 


Leu Tyr Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala 
145                 150                 155                 160 


Lys Gln Xaa Ser Xaa Phe Ser Lys Gln Xaa Pro His His Pro Phe Pro 
                165                 170                 175     


Ser Pro Ala Xaa Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro 
            180                 185                 190         


Ala Gln Asp Ile Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp 
        195                 200                 205             


Ile Tyr Gln Val Pro Pro Ser Met Asp Xaa Arg Ser Trp Glu Gly Xaa 
    210                 215                 220                 


Lys Pro Pro Ala Lys Val Val Val Pro Xaa Arg Val Gly Gln Gly Tyr 
225                 230                 235                 240 


Val Tyr Glu Ala Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg 
                245                 250                 255     


His Leu Leu Ala Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val 
            260                 265                 270         


Arg Gly Leu Leu Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Xaa Pro 
        275                 280                 285             


Pro Met Ala Val Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val 
    290                 295                 300                 


Tyr Asp Val Pro Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His 
305                 310                 315                 320 


His Ala Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp 
                325                 330                 335     


Gly Pro Leu Leu Arg Glu Glu Xaa Tyr Asp Val Pro Pro Ala Phe Ala 
            340                 345                 350         


Lys Ala Lys Pro Phe Asp Pro Ala Arg Xaa Pro Leu Val Leu Ala Ala 
        355                 360                 365             


Pro Pro Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro 
    370                 375                 380                 


Pro Ala Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly 
385                 390                 395                 400 


Pro Gly Xaa Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu 
                405                 410                 415     


Val Ala Asp Gly Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro 
            420                 425                 430         


Pro Ala Glu Arg Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser 
        435                 440                 445             


Ser Xaa Gly Ser Xaa Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val 
    450                 455                 460                 


Ala Gly Pro Gly Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala 
465                 470                 475                 480 


Leu Ala Arg Leu Gln Gln Gly Val Ser Ala Xaa Val Ala His Leu Leu 
                485                 490                 495     


Asp Leu Ala Gly Ser Ala Gly Ala Xaa Gly Ser Trp Arg Ser Pro Ser 
            500                 505                 510         


Glu Pro Gln Glu Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala 
        515                 520                 525             


Val Gln Ser Ala Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val 
    530                 535                 540                 


Gly Asn Ala Ala His Xaa Ser Asp Arg Ala Leu His Ala Lys Leu Ser 
545                 550                 555                 560 


Arg Gln Leu Gln Lys Met Glu Asp Val His Gln Xaa Leu Val Ala His 
                565                 570                 575     


Gly Gln Ala Leu Asp Ala Gly Arg Gly Gly Ser Gly Ala Xaa Leu Glu 
            580                 585                 590         


Asp Leu Asp Arg Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala 
        595                 600                 605             


Lys Gln Leu Ala Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg 
    610                 615                 620                 


Arg Xaa Lys Ala Xaa Ala Pro Gly Pro Glu Gly Gly Gly Xaa Leu His 
625                 630                 635                 640 


Pro Asn Pro Xaa Asp Lys Xaa Ser Ser Ile Gln Ser Arg Pro Leu Pro 
                645                 650                 655     


Ser Pro Pro Lys Phe Xaa Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu 
            660                 665                 670         


Asn Ser Glu Gly Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln 
        675                 680                 685             


Gly Lys Glu Glu Phe Glu Lys Xaa Gln Lys Glu Leu Leu Glu Lys Gly 
    690                 695                 700                 


Ser Ile Xaa Arg Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys 
705                 710                 715                 720 


Gln Phe Glu Arg Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp 
                725                 730                 735     


Leu Ala Asn Trp Xaa Pro Ala Gln Pro Leu Ala Pro Gly Arg Xaa Gly 
            740                 745                 750         


Gly Leu Gly Pro Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln 
        755                 760                 765             


Cys Glu Ala Asn Leu Xaa Xaa Leu Xaa Asn Ala Val Asp Ala Phe Phe 
    770                 775                 780                 


Xaa Ala Val Ala Xaa Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser 
785                 790                 795                 800 


Lys Phe Val Ile Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Xaa 
                805                 810                 815     


Leu Ser Arg Gln Ala Lys Ala Ala Asp Val Arg Ser Gln Val Xaa His 
            820                 825                 830         


Tyr Ser Asn Leu Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Xaa Xaa 
        835                 840                 845             


Lys Ala Ala Ala Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met 
    850                 855                 860                 


Val Glu Arg Val Lys Glu Leu Gly His Ser Xaa Gln Gln Phe Arg Arg 
865                 870                 875                 880 


Val Leu Gly Gln Leu Ala Ala Ala 
                885             


<210> 4033
<211> 888
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<400> 4033
Met Leu Xaa His Arg Pro Gln Glu Ala Glu Gln Arg Gly Arg Xaa Pro 
1               5                   10                  15      


Gly Pro Ser Phe Glu Trp Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn 
            20                  25                  30          


Val Ala Glu Ser Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met 
        35                  40                  45              


Xaa Val Leu Glu Gln Asp Xaa Gln Gly Leu Asp Gly Trp Trp Leu Cys 
    50                  55                  60                  


Ser Leu His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile 
65                  70                  75                  80  


Leu Val Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly Pro 
                85                  90                  95      


Pro Ala Xaa Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro 
            100                 105                 110         


Pro Ala Ser Gln Tyr Xaa Pro Met Leu Pro Asn Xaa Tyr Gln Pro Gln 
        115                 120                 125             


Pro Asp Ser Val Tyr Leu Val Pro Xaa Pro Ser Lys Ala Gln Gln Gly 
    130                 135                 140                 


Leu Tyr Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala 
145                 150                 155                 160 


Lys Gln Xaa Ser Xaa Phe Ser Lys Gln Xaa Pro His His Pro Phe Pro 
                165                 170                 175     


Ser Pro Ala Xaa Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro 
            180                 185                 190         


Ala Gln Asp Ile Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp 
        195                 200                 205             


Ile Tyr Gln Val Pro Pro Ser Met Asp Xaa Arg Ser Trp Glu Gly Xaa 
    210                 215                 220                 


Lys Pro Pro Ala Lys Val Val Val Pro Xaa Arg Val Gly Gln Gly Tyr 
225                 230                 235                 240 


Val Tyr Glu Ala Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg 
                245                 250                 255     


His Leu Leu Ala Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val 
            260                 265                 270         


Arg Gly Leu Leu Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Xaa Pro 
        275                 280                 285             


Pro Met Ala Val Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val 
    290                 295                 300                 


Tyr Asp Val Pro Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His 
305                 310                 315                 320 


His Ala Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp 
                325                 330                 335     


Gly Pro Leu Leu Arg Glu Glu Xaa Tyr Asp Val Pro Pro Ala Phe Ala 
            340                 345                 350         


Lys Ala Lys Pro Phe Asp Pro Ala Arg Xaa Pro Leu Val Leu Ala Ala 
        355                 360                 365             


Pro Pro Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro 
    370                 375                 380                 


Pro Ala Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly 
385                 390                 395                 400 


Pro Gly Xaa Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu 
                405                 410                 415     


Val Ala Asp Gly Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro 
            420                 425                 430         


Pro Ala Glu Arg Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser 
        435                 440                 445             


Ser Xaa Gly Ser Xaa Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val 
    450                 455                 460                 


Ala Gly Pro Gly Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala 
465                 470                 475                 480 


Leu Ala Arg Leu Gln Gln Gly Val Ser Ala Xaa Val Ala His Leu Leu 
                485                 490                 495     


Asp Leu Ala Gly Ser Ala Gly Ala Xaa Gly Ser Trp Arg Ser Pro Ser 
            500                 505                 510         


Glu Pro Gln Glu Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala 
        515                 520                 525             


Val Gln Ser Ala Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val 
    530                 535                 540                 


Gly Asn Ala Ala His Xaa Ser Asp Arg Ala Leu His Ala Lys Leu Ser 
545                 550                 555                 560 


Arg Gln Leu Gln Lys Met Glu Asp Val His Gln Xaa Leu Val Ala His 
                565                 570                 575     


Gly Gln Ala Leu Asp Ala Gly Arg Gly Gly Ser Gly Ala Xaa Leu Glu 
            580                 585                 590         


Asp Leu Asp Arg Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala 
        595                 600                 605             


Lys Gln Leu Ala Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg 
    610                 615                 620                 


Arg Xaa Lys Ala Xaa Ala Pro Gly Pro Glu Gly Gly Gly Xaa Leu His 
625                 630                 635                 640 


Pro Asn Pro Xaa Asp Lys Xaa Ser Ser Ile Gln Ser Arg Pro Leu Pro 
                645                 650                 655     


Ser Pro Pro Lys Phe Xaa Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu 
            660                 665                 670         


Asn Ser Glu Gly Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln 
        675                 680                 685             


Gly Lys Glu Glu Phe Glu Lys Xaa Gln Lys Glu Leu Leu Glu Lys Gly 
    690                 695                 700                 


Ser Ile Xaa Arg Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys 
705                 710                 715                 720 


Gln Phe Glu Arg Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp 
                725                 730                 735     


Leu Ala Asn Trp Xaa Pro Ala Gln Pro Leu Ala Pro Gly Arg Xaa Gly 
            740                 745                 750         


Gly Leu Gly Pro Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln 
        755                 760                 765             


Cys Glu Ala Asn Leu Xaa Xaa Leu Xaa Asn Ala Val Asp Ala Phe Phe 
    770                 775                 780                 


Xaa Ala Val Ala Xaa Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser 
785                 790                 795                 800 


Lys Phe Val Ile Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Xaa 
                805                 810                 815     


Leu Ser Arg Gln Ala Lys Ala Ala Asp Val Arg Ser Gln Val Xaa His 
            820                 825                 830         


Tyr Ser Asn Leu Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Xaa Xaa 
        835                 840                 845             


Lys Ala Ala Ala Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met 
    850                 855                 860                 


Val Glu Arg Val Lys Glu Leu Gly His Ser Xaa Gln Gln Phe Arg Arg 
865                 870                 875                 880 


Val Leu Gly Gln Leu Ala Ala Ala 
                885             


<210> 4034
<211> 870
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<400> 4034
Met Asn His Leu Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala 
1               5                   10                  15      


Glu Ser Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Xaa Val 
            20                  25                  30          


Leu Glu Gln Asp Xaa Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu 
        35                  40                  45              


His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val 
    50                  55                  60                  


Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly Pro Pro Ala 
65                  70                  75                  80  


Xaa Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro Pro Ala 
                85                  90                  95      


Ser Gln Tyr Xaa Pro Met Leu Pro Asn Xaa Tyr Gln Pro Gln Pro Asp 
            100                 105                 110         


Ser Val Tyr Leu Val Pro Xaa Pro Ser Lys Ala Gln Gln Gly Leu Tyr 
        115                 120                 125             


Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala Lys Gln 
    130                 135                 140                 


Xaa Ser Xaa Phe Ser Lys Gln Xaa Pro His His Pro Phe Pro Ser Pro 
145                 150                 155                 160 


Ala Xaa Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro Ala Gln 
                165                 170                 175     


Asp Ile Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp Ile Tyr 
            180                 185                 190         


Gln Val Pro Pro Ser Met Asp Xaa Arg Ser Trp Glu Gly Xaa Lys Pro 
        195                 200                 205             


Pro Ala Lys Val Val Val Pro Xaa Arg Val Gly Gln Gly Tyr Val Tyr 
    210                 215                 220                 


Glu Ala Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg His Leu 
225                 230                 235                 240 


Leu Ala Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly 
                245                 250                 255     


Leu Leu Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Xaa Pro Pro Met 
            260                 265                 270         


Ala Val Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr Asp 
        275                 280                 285             


Val Pro Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His His Ala 
    290                 295                 300                 


Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp Gly Pro 
305                 310                 315                 320 


Leu Leu Arg Glu Glu Xaa Tyr Asp Val Pro Pro Ala Phe Ala Lys Ala 
                325                 330                 335     


Lys Pro Phe Asp Pro Ala Arg Xaa Pro Leu Val Leu Ala Ala Pro Pro 
            340                 345                 350         


Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro Pro Ala 
        355                 360                 365             


Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly Pro Gly 
    370                 375                 380                 


Xaa Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu Val Ala 
385                 390                 395                 400 


Asp Gly Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro Pro Ala 
                405                 410                 415     


Glu Arg Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser Ser Xaa 
            420                 425                 430         


Gly Ser Xaa Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val Ala Gly 
        435                 440                 445             


Pro Gly Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala Leu Ala 
    450                 455                 460                 


Arg Leu Gln Gln Gly Val Ser Ala Xaa Val Ala His Leu Leu Asp Leu 
465                 470                 475                 480 


Ala Gly Ser Ala Gly Ala Xaa Gly Ser Trp Arg Ser Pro Ser Glu Pro 
                485                 490                 495     


Gln Glu Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala Val Gln 
            500                 505                 510         


Ser Ala Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val Gly Asn 
        515                 520                 525             


Ala Ala His Xaa Ser Asp Arg Ala Leu His Ala Lys Leu Ser Arg Gln 
    530                 535                 540                 


Leu Gln Lys Met Glu Asp Val His Gln Xaa Leu Val Ala His Gly Gln 
545                 550                 555                 560 


Ala Leu Asp Ala Gly Arg Gly Gly Ser Gly Ala Xaa Leu Glu Asp Leu 
                565                 570                 575     


Asp Arg Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala Lys Gln 
            580                 585                 590         


Leu Ala Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg Arg Xaa 
        595                 600                 605             


Lys Ala Xaa Ala Pro Gly Pro Glu Gly Gly Gly Xaa Leu His Pro Asn 
    610                 615                 620                 


Pro Xaa Asp Lys Xaa Ser Ser Ile Gln Ser Arg Pro Leu Pro Ser Pro 
625                 630                 635                 640 


Pro Lys Phe Xaa Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu Asn Ser 
                645                 650                 655     


Glu Gly Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln Gly Lys 
            660                 665                 670         


Glu Glu Phe Glu Lys Xaa Gln Lys Glu Leu Leu Glu Lys Gly Ser Ile 
        675                 680                 685             


Xaa Arg Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys Gln Phe 
    690                 695                 700                 


Glu Arg Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp Leu Ala 
705                 710                 715                 720 


Asn Trp Xaa Pro Ala Gln Pro Leu Ala Pro Gly Arg Xaa Gly Gly Leu 
                725                 730                 735     


Gly Pro Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln Cys Glu 
            740                 745                 750         


Ala Asn Leu Xaa Xaa Leu Xaa Asn Ala Val Asp Ala Phe Phe Xaa Ala 
        755                 760                 765             


Val Ala Xaa Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser Lys Phe 
    770                 775                 780                 


Val Ile Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Xaa Leu Ser 
785                 790                 795                 800 


Arg Gln Ala Lys Ala Ala Asp Val Arg Ser Gln Val Xaa His Tyr Ser 
                805                 810                 815     


Asn Leu Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Xaa Xaa Lys Ala 
            820                 825                 830         


Ala Ala Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met Val Glu 
        835                 840                 845             


Arg Val Lys Glu Leu Gly His Ser Xaa Gln Gln Phe Arg Arg Val Leu 
    850                 855                 860                 


Gly Gln Leu Ala Ala Ala 
865                 870 


<210> 4035
<211> 888
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<400> 4035
Met Asn His Leu Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala 
1               5                   10                  15      


Glu Ser Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Xaa Val 
            20                  25                  30          


Leu Glu Gln Asp Xaa Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu 
        35                  40                  45              


His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val 
    50                  55                  60                  


Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly Pro Pro Ala 
65                  70                  75                  80  


Xaa Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro Pro Ala 
                85                  90                  95      


Ser Gln Tyr Xaa Pro Met Leu Pro Asn Xaa Tyr Gln Pro Gln Pro Asp 
            100                 105                 110         


Ser Val Tyr Leu Val Pro Xaa Pro Ser Lys Ala Gln Gln Gly Leu Tyr 
        115                 120                 125             


Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala Lys Gln 
    130                 135                 140                 


Xaa Ser Xaa Phe Ser Lys Gln Xaa Pro His His Pro Phe Pro Ser Pro 
145                 150                 155                 160 


Ala Xaa Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro Ala Gln 
                165                 170                 175     


Asp Ile Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp Ile Tyr 
            180                 185                 190         


Gln Val Pro Pro Ser Met Asp Xaa Arg Ser Trp Glu Gly Xaa Lys Pro 
        195                 200                 205             


Pro Ala Lys Val Val Val Pro Xaa Arg Val Gly Gln Gly Tyr Val Tyr 
    210                 215                 220                 


Glu Ala Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg His Leu 
225                 230                 235                 240 


Leu Ala Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly 
                245                 250                 255     


Leu Leu Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Xaa Pro Pro Met 
            260                 265                 270         


Ala Val Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr Asp 
        275                 280                 285             


Val Pro Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His His Ala 
    290                 295                 300                 


Val Ser Lys Cys Gln Gly Asn Ala Arg Ala Arg Leu Arg Leu Trp Gly 
305                 310                 315                 320 


Val Trp Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp 
                325                 330                 335     


Gly Pro Leu Leu Arg Glu Glu Xaa Tyr Asp Val Pro Pro Ala Phe Ala 
            340                 345                 350         


Lys Ala Lys Pro Phe Asp Pro Ala Arg Xaa Pro Leu Val Leu Ala Ala 
        355                 360                 365             


Pro Pro Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro 
    370                 375                 380                 


Pro Ala Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly 
385                 390                 395                 400 


Pro Gly Xaa Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu 
                405                 410                 415     


Val Ala Asp Gly Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro 
            420                 425                 430         


Pro Ala Glu Arg Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser 
        435                 440                 445             


Ser Xaa Gly Ser Xaa Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val 
    450                 455                 460                 


Ala Gly Pro Gly Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala 
465                 470                 475                 480 


Leu Ala Arg Leu Gln Gln Gly Val Ser Ala Xaa Val Ala His Leu Leu 
                485                 490                 495     


Asp Leu Ala Gly Ser Ala Gly Ala Xaa Gly Ser Trp Arg Ser Pro Ser 
            500                 505                 510         


Glu Pro Gln Glu Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala 
        515                 520                 525             


Val Gln Ser Ala Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val 
    530                 535                 540                 


Gly Asn Ala Ala His Xaa Ser Asp Arg Ala Leu His Ala Lys Leu Ser 
545                 550                 555                 560 


Arg Gln Leu Gln Lys Met Glu Asp Val His Gln Xaa Leu Val Ala His 
                565                 570                 575     


Gly Gln Ala Leu Asp Ala Gly Arg Gly Gly Ser Gly Ala Xaa Leu Glu 
            580                 585                 590         


Asp Leu Asp Arg Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala 
        595                 600                 605             


Lys Gln Leu Ala Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg 
    610                 615                 620                 


Arg Xaa Lys Ala Xaa Ala Pro Gly Pro Glu Gly Gly Gly Xaa Leu His 
625                 630                 635                 640 


Pro Asn Pro Xaa Asp Lys Xaa Ser Ser Ile Gln Ser Arg Pro Leu Pro 
                645                 650                 655     


Ser Pro Pro Lys Phe Xaa Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu 
            660                 665                 670         


Asn Ser Glu Gly Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln 
        675                 680                 685             


Gly Lys Glu Glu Phe Glu Lys Xaa Gln Lys Glu Leu Leu Glu Lys Gly 
    690                 695                 700                 


Ser Ile Xaa Arg Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys 
705                 710                 715                 720 


Gln Phe Glu Arg Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp 
                725                 730                 735     


Leu Ala Asn Trp Xaa Pro Ala Gln Pro Leu Ala Pro Gly Arg Xaa Gly 
            740                 745                 750         


Gly Leu Gly Pro Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln 
        755                 760                 765             


Cys Glu Ala Asn Leu Xaa Xaa Leu Xaa Asn Ala Val Asp Ala Phe Phe 
    770                 775                 780                 


Xaa Ala Val Ala Xaa Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser 
785                 790                 795                 800 


Lys Phe Val Ile Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Xaa 
                805                 810                 815     


Leu Ser Arg Gln Ala Lys Ala Ala Asp Val Arg Ser Gln Val Xaa His 
            820                 825                 830         


Tyr Ser Asn Leu Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Xaa Xaa 
        835                 840                 845             


Lys Ala Ala Ala Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met 
    850                 855                 860                 


Val Glu Arg Val Lys Glu Leu Gly His Ser Xaa Gln Gln Phe Arg Arg 
865                 870                 875                 880 


Val Leu Gly Gln Leu Ala Ala Ala 
                885             


<210> 4036
<211> 916
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<400> 4036
Met Pro Ala Lys Pro Phe Leu Ser Ser Val Leu Leu Ser Trp Lys Val 
1               5                   10                  15      


Leu Asp Phe Ser Gly Pro Gly Pro Gln Gly Xaa Gly Gln Pro Cys Ser 
            20                  25                  30          


Cys Gly His Trp Ala Glu Gly Gln Gly Gly Pro Pro Glu Pro Ala Gly 
        35                  40                  45              


Gly Pro Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala Glu Ser 
    50                  55                  60                  


Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Xaa Val Leu Glu 
65                  70                  75                  80  


Gln Asp Xaa Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu His Gly 
                85                  90                  95      


Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val Gly Met 
            100                 105                 110         


Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly Pro Pro Ala Xaa Pro 
        115                 120                 125             


Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro Pro Ala Ser Gln 
    130                 135                 140                 


Tyr Xaa Pro Met Leu Pro Asn Xaa Tyr Gln Pro Gln Pro Asp Ser Val 
145                 150                 155                 160 


Tyr Leu Val Pro Xaa Pro Ser Lys Ala Gln Gln Gly Leu Tyr Gln Val 
                165                 170                 175     


Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala Lys Gln Xaa Ser 
            180                 185                 190         


Xaa Phe Ser Lys Gln Xaa Pro His His Pro Phe Pro Ser Pro Ala Xaa 
        195                 200                 205             


Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro Ala Gln Asp Ile 
    210                 215                 220                 


Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp Ile Tyr Gln Val 
225                 230                 235                 240 


Pro Pro Ser Met Asp Xaa Arg Ser Trp Glu Gly Xaa Lys Pro Pro Ala 
                245                 250                 255     


Lys Val Val Val Pro Xaa Arg Val Gly Gln Gly Tyr Val Tyr Glu Ala 
            260                 265                 270         


Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg His Leu Leu Ala 
        275                 280                 285             


Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly Leu Leu 
    290                 295                 300                 


Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Xaa Pro Pro Met Ala Val 
305                 310                 315                 320 


Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr Asp Val Pro 
                325                 330                 335     


Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His His Ala Val Tyr 
            340                 345                 350         


Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp Gly Pro Leu Leu 
        355                 360                 365             


Arg Glu Glu Xaa Tyr Asp Val Pro Pro Ala Phe Ala Lys Ala Lys Pro 
    370                 375                 380                 


Phe Asp Pro Ala Arg Xaa Pro Leu Val Leu Ala Ala Pro Pro Pro Asp 
385                 390                 395                 400 


Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro Pro Ala Pro Asp 
                405                 410                 415     


Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly Pro Gly Xaa Leu 
            420                 425                 430         


Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu Val Ala Asp Gly 
        435                 440                 445             


Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro Pro Ala Glu Arg 
    450                 455                 460                 


Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser Ser Xaa Gly Ser 
465                 470                 475                 480 


Xaa Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val Ala Gly Pro Gly 
                485                 490                 495     


Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala Leu Ala Arg Leu 
            500                 505                 510         


Gln Gln Gly Val Ser Ala Xaa Val Ala His Leu Leu Asp Leu Ala Gly 
        515                 520                 525             


Ser Ala Gly Ala Xaa Gly Ser Trp Arg Ser Pro Ser Glu Pro Gln Glu 
    530                 535                 540                 


Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala Val Gln Ser Ala 
545                 550                 555                 560 


Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val Gly Asn Ala Ala 
                565                 570                 575     


His Xaa Ser Asp Arg Ala Leu His Ala Lys Leu Ser Arg Gln Leu Gln 
            580                 585                 590         


Lys Met Glu Asp Val His Gln Xaa Leu Val Ala His Gly Gln Ala Leu 
        595                 600                 605             


Asp Ala Gly Arg Gly Gly Ser Gly Ala Xaa Leu Glu Asp Leu Asp Arg 
    610                 615                 620                 


Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala Lys Gln Leu Ala 
625                 630                 635                 640 


Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg Arg Xaa Lys Ala 
                645                 650                 655     


Xaa Ala Pro Gly Pro Glu Gly Gly Gly Xaa Leu His Pro Asn Pro Xaa 
            660                 665                 670         


Asp Lys Xaa Ser Ser Ile Gln Ser Arg Pro Leu Pro Ser Pro Pro Lys 
        675                 680                 685             


Phe Xaa Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu Asn Ser Glu Gly 
    690                 695                 700                 


Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln Gly Lys Glu Glu 
705                 710                 715                 720 


Phe Glu Lys Xaa Gln Lys Glu Leu Leu Glu Lys Gly Ser Ile Xaa Arg 
                725                 730                 735     


Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys Gln Phe Glu Arg 
            740                 745                 750         


Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp Leu Ala Asn Trp 
        755                 760                 765             


Xaa Pro Ala Gln Pro Leu Ala Pro Gly Arg Xaa Gly Gly Leu Gly Pro 
    770                 775                 780                 


Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln Cys Glu Ala Asn 
785                 790                 795                 800 


Leu Xaa Xaa Leu Xaa Asn Ala Val Asp Ala Phe Phe Xaa Ala Val Ala 
                805                 810                 815     


Xaa Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser Lys Phe Val Ile 
            820                 825                 830         


Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Xaa Leu Ser Arg Gln 
        835                 840                 845             


Ala Lys Ala Ala Asp Val Arg Ser Gln Val Xaa His Tyr Ser Asn Leu 
    850                 855                 860                 


Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Xaa Xaa Lys Ala Ala Ala 
865                 870                 875                 880 


Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met Val Glu Arg Val 
                885                 890                 895     


Lys Glu Leu Gly His Ser Xaa Gln Gln Phe Arg Arg Val Leu Gly Gln 
            900                 905                 910         


Leu Ala Ala Ala 
        915     


<210> 4037
<211> 57
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 4037
Met Pro Ala Lys Pro Phe Leu Ser Ser Val Leu Leu Ser Trp Lys Val 
1               5                   10                  15      


Leu Asp Phe Ser Gly Pro Gly Pro Gln Gly Xaa Gly Gln Pro Cys Ser 
            20                  25                  30          


Cys Gly His Trp Ala Glu Gly Gln Gly Gly Pro Pro Glu Pro Ala Gly 
        35                  40                  45              


Gly Pro Val Ser Gln Gly Ser Ser Asp 
    50                  55          


<210> 4038
<211> 722
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<400> 4038
Met Gln Gly Lys Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala 
1               5                   10                  15      


Glu Ser Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Xaa Val 
            20                  25                  30          


Leu Glu Gln Asp Xaa Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu 
        35                  40                  45              


His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val 
    50                  55                  60                  


Val Val Pro Xaa Arg Val Gly Gln Gly Tyr Val Tyr Glu Ala Ala Gln 
65                  70                  75                  80  


Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg His Leu Leu Ala Pro Gly 
                85                  90                  95      


Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly Leu Leu Pro Ser 
            100                 105                 110         


Gln Tyr Gly Gln Glu Val Tyr Asp Xaa Pro Pro Met Ala Val Lys Gly 
        115                 120                 125             


Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr Asp Val Pro Pro Ser 
    130                 135                 140                 


Val Glu Lys Gly Leu Pro Pro Ser Asn His His Ala Val Tyr Asp Val 
145                 150                 155                 160 


Pro Pro Ser Val Ser Lys Asp Val Pro Asp Gly Pro Leu Leu Arg Glu 
                165                 170                 175     


Glu Xaa Tyr Asp Val Pro Pro Ala Phe Ala Lys Ala Lys Pro Phe Asp 
            180                 185                 190         


Pro Ala Arg Xaa Pro Leu Val Leu Ala Ala Pro Pro Pro Asp Ser Pro 
        195                 200                 205             


Pro Ala Glu Asp Val Tyr Asp Val Pro Pro Pro Ala Pro Asp Leu Tyr 
    210                 215                 220                 


Asp Val Pro Pro Gly Leu Arg Arg Pro Gly Pro Gly Xaa Leu Tyr Asp 
225                 230                 235                 240 


Val Pro Arg Glu Arg Val Leu Pro Pro Glu Val Ala Asp Gly Gly Val 
                245                 250                 255     


Val Asp Ser Gly Val Tyr Ala Val Pro Pro Pro Ala Glu Arg Glu Ala 
            260                 265                 270         


Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser Ser Xaa Gly Ser Xaa Arg 
        275                 280                 285             


Ser Ser Gln Ser Ala Ser Ser Leu Glu Val Ala Gly Pro Gly Arg Glu 
    290                 295                 300                 


Pro Leu Glu Leu Glu Val Ala Val Glu Ala Leu Ala Arg Leu Gln Gln 
305                 310                 315                 320 


Gly Val Ser Ala Xaa Val Ala His Leu Leu Asp Leu Ala Gly Ser Ala 
                325                 330                 335     


Gly Ala Xaa Gly Ser Trp Arg Ser Pro Ser Glu Pro Gln Glu Pro Leu 
            340                 345                 350         


Val Gln Asp Leu Gln Ala Ala Val Ala Ala Val Gln Ser Ala Val His 
        355                 360                 365             


Glu Leu Leu Glu Phe Ala Arg Ser Ala Val Gly Asn Ala Ala His Xaa 
    370                 375                 380                 


Ser Asp Arg Ala Leu His Ala Lys Leu Ser Arg Gln Leu Gln Lys Met 
385                 390                 395                 400 


Glu Asp Val His Gln Xaa Leu Val Ala His Gly Gln Ala Leu Asp Ala 
                405                 410                 415     


Gly Arg Gly Gly Ser Gly Ala Xaa Leu Glu Asp Leu Asp Arg Leu Val 
            420                 425                 430         


Ala Cys Ser Arg Ala Val Pro Glu Asp Ala Lys Gln Leu Ala Ser Phe 
        435                 440                 445             


Leu His Gly Asn Ala Ser Leu Leu Phe Arg Arg Xaa Lys Ala Xaa Ala 
    450                 455                 460                 


Pro Gly Pro Glu Gly Gly Gly Xaa Leu His Pro Asn Pro Xaa Asp Lys 
465                 470                 475                 480 


Xaa Ser Ser Ile Gln Ser Arg Pro Leu Pro Ser Pro Pro Lys Phe Xaa 
                485                 490                 495     


Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu Asn Ser Glu Gly Gly Trp 
            500                 505                 510         


Met Glu Asp Tyr Asp Tyr Val His Leu Gln Gly Lys Glu Glu Phe Glu 
        515                 520                 525             


Lys Xaa Gln Lys Glu Leu Leu Glu Lys Gly Ser Ile Xaa Arg Gln Gly 
    530                 535                 540                 


Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys Gln Phe Glu Arg Leu Glu 
545                 550                 555                 560 


Gln Glu Val Ser Arg Pro Ile Asp His Asp Leu Ala Asn Trp Xaa Pro 
                565                 570                 575     


Ala Gln Pro Leu Ala Pro Gly Arg Xaa Gly Gly Leu Gly Pro Ser Asp 
            580                 585                 590         


Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln Cys Glu Ala Asn Leu Xaa 
        595                 600                 605             


Xaa Leu Xaa Asn Ala Val Asp Ala Phe Phe Xaa Ala Val Ala Xaa Asn 
    610                 615                 620                 


Gln Pro Pro Lys Ile Phe Val Ala His Ser Lys Phe Val Ile Leu Ser 
625                 630                 635                 640 


Ala His Lys Leu Val Phe Ile Gly Asp Xaa Leu Ser Arg Gln Ala Lys 
                645                 650                 655     


Ala Ala Asp Val Arg Ser Gln Val Xaa His Tyr Ser Asn Leu Leu Cys 
            660                 665                 670         


Asp Leu Leu Arg Gly Ile Val Ala Xaa Xaa Lys Ala Ala Ala Leu Gln 
        675                 680                 685             


Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met Val Glu Arg Val Lys Glu 
    690                 695                 700                 


Leu Gly His Ser Xaa Gln Gln Phe Arg Arg Val Leu Gly Gln Leu Ala 
705                 710                 715                 720 


Ala Ala 
        


<210> 4039
<211> 870
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<400> 4039
Met Ser Val Pro Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala 
1               5                   10                  15      


Glu Ser Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Xaa Val 
            20                  25                  30          


Leu Glu Gln Asp Xaa Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu 
        35                  40                  45              


His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val 
    50                  55                  60                  


Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly Pro Pro Ala 
65                  70                  75                  80  


Xaa Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro Pro Ala 
                85                  90                  95      


Ser Gln Tyr Xaa Pro Met Leu Pro Asn Xaa Tyr Gln Pro Gln Pro Asp 
            100                 105                 110         


Ser Val Tyr Leu Val Pro Xaa Pro Ser Lys Ala Gln Gln Gly Leu Tyr 
        115                 120                 125             


Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala Lys Gln 
    130                 135                 140                 


Xaa Ser Xaa Phe Ser Lys Gln Xaa Pro His His Pro Phe Pro Ser Pro 
145                 150                 155                 160 


Ala Xaa Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro Ala Gln 
                165                 170                 175     


Asp Ile Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp Ile Tyr 
            180                 185                 190         


Gln Val Pro Pro Ser Met Asp Xaa Arg Ser Trp Glu Gly Xaa Lys Pro 
        195                 200                 205             


Pro Ala Lys Val Val Val Pro Xaa Arg Val Gly Gln Gly Tyr Val Tyr 
    210                 215                 220                 


Glu Ala Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg His Leu 
225                 230                 235                 240 


Leu Ala Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly 
                245                 250                 255     


Leu Leu Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Xaa Pro Pro Met 
            260                 265                 270         


Ala Val Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr Asp 
        275                 280                 285             


Val Pro Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His His Ala 
    290                 295                 300                 


Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp Gly Pro 
305                 310                 315                 320 


Leu Leu Arg Glu Glu Xaa Tyr Asp Val Pro Pro Ala Phe Ala Lys Ala 
                325                 330                 335     


Lys Pro Phe Asp Pro Ala Arg Xaa Pro Leu Val Leu Ala Ala Pro Pro 
            340                 345                 350         


Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro Pro Ala 
        355                 360                 365             


Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly Pro Gly 
    370                 375                 380                 


Xaa Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu Val Ala 
385                 390                 395                 400 


Asp Gly Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro Pro Ala 
                405                 410                 415     


Glu Arg Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser Ser Xaa 
            420                 425                 430         


Gly Ser Xaa Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val Ala Gly 
        435                 440                 445             


Pro Gly Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala Leu Ala 
    450                 455                 460                 


Arg Leu Gln Gln Gly Val Ser Ala Xaa Val Ala His Leu Leu Asp Leu 
465                 470                 475                 480 


Ala Gly Ser Ala Gly Ala Xaa Gly Ser Trp Arg Ser Pro Ser Glu Pro 
                485                 490                 495     


Gln Glu Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala Val Gln 
            500                 505                 510         


Ser Ala Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val Gly Asn 
        515                 520                 525             


Ala Ala His Xaa Ser Asp Arg Ala Leu His Ala Lys Leu Ser Arg Gln 
    530                 535                 540                 


Leu Gln Lys Met Glu Asp Val His Gln Xaa Leu Val Ala His Gly Gln 
545                 550                 555                 560 


Ala Leu Asp Ala Gly Arg Gly Gly Ser Gly Ala Xaa Leu Glu Asp Leu 
                565                 570                 575     


Asp Arg Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala Lys Gln 
            580                 585                 590         


Leu Ala Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg Arg Xaa 
        595                 600                 605             


Lys Ala Xaa Ala Pro Gly Pro Glu Gly Gly Gly Xaa Leu His Pro Asn 
    610                 615                 620                 


Pro Xaa Asp Lys Xaa Ser Ser Ile Gln Ser Arg Pro Leu Pro Ser Pro 
625                 630                 635                 640 


Pro Lys Phe Xaa Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu Asn Ser 
                645                 650                 655     


Glu Gly Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln Gly Lys 
            660                 665                 670         


Glu Glu Phe Glu Lys Xaa Gln Lys Glu Leu Leu Glu Lys Gly Ser Ile 
        675                 680                 685             


Xaa Arg Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys Gln Phe 
    690                 695                 700                 


Glu Arg Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp Leu Ala 
705                 710                 715                 720 


Asn Trp Xaa Pro Ala Gln Pro Leu Ala Pro Gly Arg Xaa Gly Gly Leu 
                725                 730                 735     


Gly Pro Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln Cys Glu 
            740                 745                 750         


Ala Asn Leu Xaa Xaa Leu Xaa Asn Ala Val Asp Ala Phe Phe Xaa Ala 
        755                 760                 765             


Val Ala Xaa Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser Lys Phe 
    770                 775                 780                 


Val Ile Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Xaa Leu Ser 
785                 790                 795                 800 


Arg Gln Ala Lys Ala Ala Asp Val Arg Ser Gln Val Xaa His Tyr Ser 
                805                 810                 815     


Asn Leu Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Xaa Xaa Lys Ala 
            820                 825                 830         


Ala Ala Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met Val Glu 
        835                 840                 845             


Arg Val Lys Glu Leu Gly His Ser Xaa Gln Gln Phe Arg Arg Val Leu 
    850                 855                 860                 


Gly Gln Leu Ala Ala Ala 
865                 870 


<210> 4040
<211> 50
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<400> 4040
Met Xaa Val Leu Glu Gln Asp Xaa Gln Gly Leu Asp Gly Trp Trp Leu 
1               5                   10                  15      


Cys Ser Leu His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys 
            20                  25                  30          


Ile Leu Val Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly 
        35                  40                  45              


Pro Pro 
    50  


<210> 4041
<211> 59
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 4041
Met Xaa Val Leu Glu Gln Asp Xaa Gln Gly Leu Asp Gly Trp Trp Leu 
1               5                   10                  15      


Cys Ser Leu His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys 
            20                  25                  30          


Ile Leu Val Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly 
        35                  40                  45              


Pro Pro Ala Xaa Pro Ala Gln Pro Gln Pro Gly 
    50                  55                  


<210> 4042
<211> 80
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<400> 4042
Met Xaa Val Leu Glu Gln Asp Xaa Gln Gly Leu Asp Gly Trp Trp Leu 
1               5                   10                  15      


Cys Ser Leu His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys 
            20                  25                  30          


Ile Leu Val Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly 
        35                  40                  45              


Pro Pro Ala Xaa Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala 
    50                  55                  60                  


Pro Pro Ala Ser Gln Tyr Xaa Pro Met Leu Pro Asn Xaa Tyr Gln Pro 
65                  70                  75                  80  


<210> 4043
<211> 120
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<400> 4043
Met Xaa Val Leu Glu Gln Asp Xaa Gln Gly Leu Asp Gly Trp Trp Leu 
1               5                   10                  15      


Cys Ser Leu His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys 
            20                  25                  30          


Ile Leu Val Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly 
        35                  40                  45              


Pro Pro Ala Xaa Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala 
    50                  55                  60                  


Pro Pro Ala Ser Gln Tyr Xaa Pro Met Leu Pro Asn Xaa Tyr Gln Pro 
65                  70                  75                  80  


Gln Pro Asp Ser Val Tyr Leu Val Pro Xaa Pro Ser Lys Ala Gln Gln 
                85                  90                  95      


Gly Leu Tyr Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro 
            100                 105                 110         


Ala Lys Gln Xaa Ser Xaa Phe Ser 
        115                 120 


<210> 4044
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<400> 4044
Met Xaa Val Leu Glu Gln Asp Xaa Gln Gly Leu Asp Gly Trp Trp Leu 
1               5                   10                  15      


Cys Ser Leu His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys 
            20                  25                  30          


Ile Leu Val Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly 
        35                  40                  45              


Pro Pro Ala Xaa Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala 
    50                  55                  60                  


Pro Pro Ala Ser Gln Tyr Xaa Pro Met Leu Pro Asn Xaa Tyr Gln Pro 
65                  70                  75                  80  


Gln Pro Asp Ser Val Tyr Leu Val Pro Xaa Pro Ser Lys Ala Gln Gln 
                85                  90                  95      


Gly Leu Tyr Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro 
            100                 105                 110         


Ala Lys Gln Xaa Ser Xaa Phe Ser Lys Gln Xaa Pro His His Pro Phe 
        115                 120                 125             


<210> 4045
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<400> 4045
Met Xaa Val Leu Glu Gln Asp Xaa Gln Gly Leu Asp Gly Trp Trp Leu 
1               5                   10                  15      


Cys Ser Leu His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys 
            20                  25                  30          


Ile Leu Val Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly 
        35                  40                  45              


Pro Pro Ala Xaa Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala 
    50                  55                  60                  


Pro Pro Ala Ser Gln Tyr Xaa Pro Met Leu Pro Asn Xaa Tyr Gln Pro 
65                  70                  75                  80  


Gln Pro Asp Ser Val Tyr Leu Val Pro Xaa Pro Ser Lys Ala Gln Gln 
                85                  90                  95      


Gly Leu Tyr Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro 
            100                 105                 110         


Ala Lys Gln Xaa Ser Xaa Phe Ser Lys Gln Xaa Pro His His Pro Phe 
        115                 120                 125             


Pro Ser Pro Ala Xaa 
    130             


<210> 4046
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<400> 4046
Met Xaa Val Leu Glu Gln Asp Xaa Gln Gly Leu Asp Gly Trp Trp Leu 
1               5                   10                  15      


Cys Ser Leu His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys 
            20                  25                  30          


Ile Leu Val Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly 
        35                  40                  45              


Pro Pro Ala Xaa Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala 
    50                  55                  60                  


Pro Pro Ala Ser Gln Tyr Xaa Pro Met Leu Pro Asn Xaa Tyr Gln Pro 
65                  70                  75                  80  


Gln Pro Asp Ser Val Tyr Leu Val Pro Xaa Pro Ser Lys Ala Gln Gln 
                85                  90                  95      


Gly Leu Tyr Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro 
            100                 105                 110         


Ala Lys Gln Xaa Ser Xaa Phe Ser Lys Gln Xaa Pro His His Pro Phe 
        115                 120                 125             


Pro Ser Pro Ala Xaa Asp Leu 
    130                 135 


<210> 4047
<211> 238
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<400> 4047
Xaa Pro Gln Phe Gln Ser Pro Pro Ala Lys Gln Xaa Ser Xaa Phe Ser 
1               5                   10                  15      


Lys Gln Xaa Pro His His Pro Phe Pro Ser Pro Ala Xaa Asp Leu Tyr 
            20                  25                  30          


Gln Val Pro Pro Gly Pro Gly Gly Pro Ala Gln Asp Ile Tyr Gln Val 
        35                  40                  45              


Pro Pro Ser Ala Gly Met Gly His Asp Ile Tyr Gln Val Pro Pro Ser 
    50                  55                  60                  


Met Asp Xaa Arg Ser Trp Glu Gly Xaa Lys Pro Pro Ala Lys Val Val 
65                  70                  75                  80  


Val Pro Xaa Arg Val Gly Gln Gly Tyr Val Tyr Glu Ala Ala Gln Pro 
                85                  90                  95      


Glu Gln Asp Glu Tyr Asp Ile Pro Arg His Leu Leu Ala Pro Gly Pro 
            100                 105                 110         


Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly Leu Leu Pro Ser Gln 
        115                 120                 125             


Tyr Gly Gln Glu Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val 
    130                 135                 140                 


Pro Asp Gly Pro Leu Leu Arg Glu Glu Xaa Tyr Asp Val Pro Pro Ala 
145                 150                 155                 160 


Phe Ala Lys Ala Lys Pro Phe Asp Pro Ala Arg Xaa Pro Leu Val Leu 
                165                 170                 175     


Ala Ala Pro Pro Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Asp Val 
            180                 185                 190         


Pro Pro Pro Ala Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg 
        195                 200                 205             


Pro Gly Pro Gly Xaa Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro 
    210                 215                 220                 


Pro Glu Val Ala Asp Gly Gly Val Val Asp Ser Gly Val Tyr 
225                 230                 235             


<210> 4048
<211> 825
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<400> 4048
Met Ala Ala Gly Lys Phe Ala Ser Leu Pro Arg Asn Met Pro Val Asn 
1               5                   10                  15      


His Gln Phe Pro Leu Ala Ser Ser Met Asp Leu Leu Ser Ser Arg Ser 
            20                  25                  30          


Pro Leu Ala Glu His Arg Pro Asp Ala Tyr Gln Asp Val Ser Ile His 
        35                  40                  45              


Gly Xaa Leu Pro Arg Lys Lys Lys Gly Pro Pro Pro Ile Arg Ser Cys 
    50                  55                  60                  


Asp Asp Phe Ser His Met Gly Xaa Leu Pro His Ser Lys Ser Pro Arg 
65                  70                  75                  80  


Gln Asn Ser Pro Val Xaa Gln Asp Gly Ile Gln Glu Ser Pro Trp Gln 
                85                  90                  95      


Asp Arg His Gly Glu Xaa Phe Xaa Phe Arg Asp Pro His Leu Leu Asp 
            100                 105                 110         


Pro Xaa Val Glu Tyr Val Lys Phe Ser Lys Glu Arg His Ile Met Asp 
        115                 120                 125             


Arg Xaa Pro Glu Lys Leu Lys Lys Glu Leu Glu Glu Glu Leu Leu Leu 
    130                 135                 140                 


Ser Ser Glu Asp Leu Arg Ser His Ala Trp Tyr His Gly Arg Ile Pro 
145                 150                 155                 160 


Arg Gln Val Ser Glu Asn Leu Val Gln Arg Asp Gly Asp Phe Leu Val 
                165                 170                 175     


Arg Asp Ser Leu Ser Ser Pro Gly Asn Phe Val Leu Xaa Cys Gln Trp 
            180                 185                 190         


Lys Asn Leu Ala Gln His Phe Lys Ile Asn Arg Xaa Val Leu Arg Leu 
        195                 200                 205             


Ser Glu Ala Tyr Ser Arg Val Gln Tyr Gln Phe Glu Met Glu Ser Phe 
    210                 215                 220                 


Asp Ser Ile Pro Gly Leu Val Arg Cys Tyr Val Gly Asn Arg Arg Pro 
225                 230                 235                 240 


Ile Ser Gln Gln Ser Gly Ala Ile Ile Phe Gln Pro Ile Asn Arg Xaa 
                245                 250                 255     


Val Pro Leu Arg Cys Leu Glu Glu His Tyr Gly Xaa Ser Pro Gly Gln 
            260                 265                 270         


Ala Arg Glu Gly Ser Leu Xaa Lys Gly Arg Pro Asp Val Ala Lys Arg 
        275                 280                 285             


Leu Ser Leu Xaa Met Gly Gly Val Gln Ala Arg Glu Gln Asn Leu Pro 
    290                 295                 300                 


Arg Gly Asn Leu Leu Arg Asn Lys Glu Lys Ser Gly Ser Gln Pro Ala 
305                 310                 315                 320 


Cys Leu Asp His Met Gln Asp Arg Arg Ala Leu Ser Leu Lys Ala His 
                325                 330                 335     


Gln Ser Glu Ser Tyr Leu Pro Ile Gly Cys Lys Leu Pro Pro Gln Ser 
            340                 345                 350         


Ser Gly Val Asp Xaa Ser Pro Cys Pro Asn Ser Pro Val Phe Arg Xaa 
        355                 360                 365             


Gly Ser Glu Pro Ala Leu Ser Pro Ala Val Val Arg Arg Val Ser Ser 
    370                 375                 380                 


Asp Ala Arg Ala Gly Glu Ala Leu Arg Gly Ser Asp Ser Gln Leu Cys 
385                 390                 395                 400 


Pro Lys Pro Pro Pro Lys Pro Cys Lys Val Pro Phe Leu Lys Val Pro 
                405                 410                 415     


Ser Ser Pro Ser Ala Trp Leu Asn Ser Glu Ala Asn Tyr Cys Glu Leu 
            420                 425                 430         


Asn Pro Ala Phe Ala Xaa Gly Cys Gly Arg Gly Ala Lys Leu Pro Ser 
        435                 440                 445             


Cys Ala Gln Gly Ser His Xaa Glu Leu Leu Xaa Ala Lys Gln Asn Glu 
    450                 455                 460                 


Ala Pro Gly Pro Arg Asn Ser Gly Val Asn Tyr Leu Ile Leu Asp Asp 
465                 470                 475                 480 


Asp Asp Arg Glu Arg Pro Trp Glu Pro Ala Ala Ala Gln Met Glu Lys 
                485                 490                 495     


Gly Gln Trp Asp Lys Gly Glu Phe Val Xaa Pro Leu Leu Glu Xaa Val 
            500                 505                 510         


Ser Ser Phe Arg Pro Asn Glu Phe Glu Ser Lys Phe Leu Pro Pro Glu 
        515                 520                 525             


Asn Lys Pro Leu Glu Xaa Ala Met Leu Lys Arg Ala Lys Glu Leu Phe 
    530                 535                 540                 


Xaa Asn Asn Asp Pro Lys Val Ile Ala Gln His Val Leu Ser Met Asp 
545                 550                 555                 560 


Cys Arg Val Ala Arg Ile Leu Gly Val Ser Glu Glu Met Arg Arg Asn 
                565                 570                 575     


Met Gly Val Ser Ser Gly Leu Glu Leu Ile Xaa Leu Pro His Gly His 
            580                 585                 590         


Gln Leu Arg Leu Asp Ile Ile Glu Arg His Asn Xaa Met Ala Ile Gly 
        595                 600                 605             


Ile Ala Val Asp Ile Leu Gly Cys Xaa Gly Xaa Leu Glu Asp Arg Ala 
    610                 615                 620                 


Ala Xaa Leu Ser Lys Ile Ile Gln Val Ala Val Glu Leu Lys Asp Ser 
625                 630                 635                 640 


Met Gly Asp Leu Tyr Ser Phe Ser Ala Leu Met Lys Ala Leu Glu Met 
                645                 650                 655     


Pro Gln Ile Xaa Arg Leu Glu Lys Xaa Trp Xaa Ala Leu Arg His Gln 
            660                 665                 670         


Tyr Xaa Gln Xaa Ala Ile Leu Tyr Glu Lys Gln Leu Lys Pro Phe Ser 
        675                 680                 685             


Lys Leu Leu His Glu Gly Arg Glu Ser Xaa Cys Val Pro Pro Asn Asn 
    690                 695                 700                 


Val Ser Val Pro Leu Leu Met Pro Leu Val Xaa Leu Met Glu Arg Gln 
705                 710                 715                 720 


Ala Val Xaa Phe Glu Gly Xaa Asp Met Trp Glu Lys Asn Asp Gln Ser 
                725                 730                 735     


Cys Glu Ile Met Leu Asn His Leu Ala Xaa Ala Arg Phe Met Ala Glu 
            740                 745                 750         


Ala Ala Asp Ser Tyr Arg Met Asn Ala Glu Arg Ile Leu Ala Gly Phe 
        755                 760                 765             


Gln Pro Asp Glu Glu Met Asn Glu Ile Cys Lys Xaa Glu Phe Gln Met 
    770                 775                 780                 


Arg Leu Leu Trp Gly Ser Lys Gly Ala Gln Val Asn Gln Xaa Glu Arg 
785                 790                 795                 800 


Tyr Glu Lys Phe Asn Gln Ile Leu Xaa Ala Leu Ser Arg Lys Leu Glu 
                805                 810                 815     


Pro Pro Pro Val Lys Gln Ala Glu Leu 
            820                 825 


<210> 4049
<211> 734
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<400> 4049
Met Pro Lys Glu Cys Ser Ala Phe His Ala Leu Ser Ala Ala Leu Cys 
1               5                   10                  15      


Cys Phe Tyr His Arg Lys Ser Phe Ile Gly Val Lys Phe Ser Lys Glu 
            20                  25                  30          


Arg His Ile Met Asp Arg Xaa Pro Glu Lys Leu Lys Lys Glu Leu Glu 
        35                  40                  45              


Glu Glu Leu Leu Leu Ser Ser Glu Asp Leu Arg Ser His Ala Trp Tyr 
    50                  55                  60                  


His Gly Arg Ile Pro Arg Gln Val Ser Glu Asn Leu Val Gln Arg Asp 
65                  70                  75                  80  


Gly Asp Phe Leu Val Arg Asp Ser Leu Ser Ser Pro Gly Asn Phe Val 
                85                  90                  95      


Leu Xaa Cys Gln Trp Lys Asn Leu Ala Gln His Phe Lys Ile Asn Arg 
            100                 105                 110         


Xaa Val Leu Arg Leu Ser Glu Ala Tyr Ser Arg Val Gln Tyr Gln Phe 
        115                 120                 125             


Glu Met Glu Ser Phe Asp Ser Ile Pro Gly Leu Val Arg Cys Tyr Val 
    130                 135                 140                 


Gly Asn Arg Arg Pro Ile Ser Gln Gln Ser Gly Ala Ile Ile Phe Gln 
145                 150                 155                 160 


Pro Ile Asn Arg Xaa Val Pro Leu Arg Cys Leu Glu Glu His Tyr Gly 
                165                 170                 175     


Xaa Ser Pro Gly Gln Ala Arg Glu Gly Ser Leu Xaa Lys Gly Arg Pro 
            180                 185                 190         


Asp Val Ala Lys Arg Leu Ser Leu Xaa Met Gly Gly Val Gln Ala Arg 
        195                 200                 205             


Glu Gln Asn Leu Pro Arg Gly Asn Leu Leu Arg Asn Lys Glu Lys Ser 
    210                 215                 220                 


Gly Ser Gln Pro Ala Cys Leu Asp His Met Gln Asp Arg Arg Ala Leu 
225                 230                 235                 240 


Ser Leu Lys Ala His Gln Ser Glu Ser Tyr Leu Pro Ile Gly Cys Lys 
                245                 250                 255     


Leu Pro Pro Gln Ser Ser Gly Val Asp Xaa Ser Pro Cys Pro Asn Ser 
            260                 265                 270         


Pro Val Phe Arg Xaa Gly Ser Glu Pro Ala Leu Ser Pro Ala Val Val 
        275                 280                 285             


Arg Arg Val Ser Ser Asp Ala Arg Ala Gly Glu Ala Leu Arg Gly Ser 
    290                 295                 300                 


Asp Ser Gln Leu Cys Pro Lys Pro Pro Pro Lys Pro Cys Lys Val Pro 
305                 310                 315                 320 


Phe Leu Lys Val Pro Ser Ser Pro Ser Ala Trp Leu Asn Ser Glu Ala 
                325                 330                 335     


Asn Tyr Cys Glu Leu Asn Pro Ala Phe Ala Xaa Gly Cys Gly Arg Gly 
            340                 345                 350         


Ala Lys Leu Pro Ser Cys Ala Gln Gly Ser His Xaa Glu Leu Leu Xaa 
        355                 360                 365             


Ala Lys Gln Asn Glu Ala Pro Gly Pro Arg Asn Ser Gly Val Asn Tyr 
    370                 375                 380                 


Leu Ile Leu Asp Asp Asp Asp Arg Glu Arg Pro Trp Glu Pro Ala Ala 
385                 390                 395                 400 


Ala Gln Met Glu Lys Gly Gln Trp Asp Lys Gly Glu Phe Val Xaa Pro 
                405                 410                 415     


Leu Leu Glu Xaa Val Ser Ser Phe Arg Pro Asn Glu Phe Glu Ser Lys 
            420                 425                 430         


Phe Leu Pro Pro Glu Asn Lys Pro Leu Glu Xaa Ala Met Leu Lys Arg 
        435                 440                 445             


Ala Lys Glu Leu Phe Xaa Asn Asn Asp Pro Lys Val Ile Ala Gln His 
    450                 455                 460                 


Val Leu Ser Met Asp Cys Arg Val Ala Arg Ile Leu Gly Val Ser Glu 
465                 470                 475                 480 


Glu Met Arg Arg Asn Met Gly Val Ser Ser Gly Leu Glu Leu Ile Xaa 
                485                 490                 495     


Leu Pro His Gly His Gln Leu Arg Leu Asp Ile Ile Glu Arg His Asn 
            500                 505                 510         


Xaa Met Ala Ile Gly Ile Ala Val Asp Ile Leu Gly Cys Xaa Gly Xaa 
        515                 520                 525             


Leu Glu Asp Arg Ala Ala Xaa Leu Ser Lys Ile Ile Gln Val Ala Val 
    530                 535                 540                 


Glu Leu Lys Asp Ser Met Gly Asp Leu Tyr Ser Phe Ser Ala Leu Met 
545                 550                 555                 560 


Lys Ala Leu Glu Met Pro Gln Ile Xaa Arg Leu Glu Lys Xaa Trp Xaa 
                565                 570                 575     


Ala Leu Arg His Gln Tyr Xaa Gln Xaa Ala Ile Leu Tyr Glu Lys Gln 
            580                 585                 590         


Leu Lys Pro Phe Ser Lys Leu Leu His Glu Gly Arg Glu Ser Xaa Cys 
        595                 600                 605             


Val Pro Pro Asn Asn Val Ser Val Pro Leu Leu Met Pro Leu Val Xaa 
    610                 615                 620                 


Leu Met Glu Arg Gln Ala Val Xaa Phe Glu Gly Xaa Asp Met Trp Glu 
625                 630                 635                 640 


Lys Asn Asp Gln Ser Cys Glu Ile Met Leu Asn His Leu Ala Xaa Ala 
                645                 650                 655     


Arg Phe Met Ala Glu Ala Ala Asp Ser Tyr Arg Met Asn Ala Glu Arg 
            660                 665                 670         


Ile Leu Ala Gly Phe Gln Pro Asp Glu Glu Met Asn Glu Ile Cys Lys 
        675                 680                 685             


Xaa Glu Phe Gln Met Arg Leu Leu Trp Gly Ser Lys Gly Ala Gln Val 
    690                 695                 700                 


Asn Gln Xaa Glu Arg Tyr Glu Lys Phe Asn Gln Ile Leu Xaa Ala Leu 
705                 710                 715                 720 


Ser Arg Lys Leu Glu Pro Pro Pro Val Lys Gln Ala Glu Leu 
                725                 730                 


<210> 4050
<211> 501
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<400> 4050
Met Gln Asp Arg Arg Ala Leu Ser Leu Lys Ala His Gln Ser Glu Ser 
1               5                   10                  15      


Tyr Leu Pro Ile Gly Cys Lys Leu Pro Pro Gln Ser Ser Gly Val Asp 
            20                  25                  30          


Xaa Ser Pro Cys Pro Asn Ser Pro Val Phe Arg Xaa Gly Ser Glu Pro 
        35                  40                  45              


Ala Leu Ser Pro Ala Val Val Arg Arg Val Ser Ser Asp Ala Arg Ala 
    50                  55                  60                  


Gly Glu Ala Leu Arg Gly Ser Asp Ser Gln Leu Cys Pro Lys Pro Pro 
65                  70                  75                  80  


Pro Lys Pro Cys Lys Val Pro Phe Leu Lys Val Pro Ser Ser Pro Ser 
                85                  90                  95      


Ala Trp Leu Asn Ser Glu Ala Asn Tyr Cys Glu Leu Asn Pro Ala Phe 
            100                 105                 110         


Ala Xaa Gly Cys Gly Arg Gly Ala Lys Leu Pro Ser Cys Ala Gln Gly 
        115                 120                 125             


Ser His Xaa Glu Leu Leu Xaa Ala Lys Gln Asn Glu Ala Pro Gly Pro 
    130                 135                 140                 


Arg Asn Ser Gly Val Asn Tyr Leu Ile Leu Asp Asp Asp Asp Arg Glu 
145                 150                 155                 160 


Arg Pro Trp Glu Pro Ala Ala Ala Gln Met Glu Lys Gly Gln Trp Asp 
                165                 170                 175     


Lys Gly Glu Phe Val Xaa Pro Leu Leu Glu Xaa Val Ser Ser Phe Arg 
            180                 185                 190         


Pro Asn Glu Phe Glu Ser Lys Phe Leu Pro Pro Glu Asn Lys Pro Leu 
        195                 200                 205             


Glu Xaa Ala Met Leu Lys Arg Ala Lys Glu Leu Phe Xaa Asn Asn Asp 
    210                 215                 220                 


Pro Lys Val Ile Ala Gln His Val Leu Ser Met Asp Cys Arg Val Ala 
225                 230                 235                 240 


Arg Ile Leu Gly Val Ser Glu Glu Met Arg Arg Asn Met Gly Val Ser 
                245                 250                 255     


Ser Gly Leu Glu Leu Ile Xaa Leu Pro His Gly His Gln Leu Arg Leu 
            260                 265                 270         


Asp Ile Ile Glu Arg His Asn Xaa Met Ala Ile Gly Ile Ala Val Asp 
        275                 280                 285             


Ile Leu Gly Cys Xaa Gly Xaa Leu Glu Asp Arg Ala Ala Xaa Leu Ser 
    290                 295                 300                 


Lys Ile Ile Gln Val Ala Val Glu Leu Lys Asp Ser Met Gly Asp Leu 
305                 310                 315                 320 


Tyr Ser Phe Ser Ala Leu Met Lys Ala Leu Glu Met Pro Gln Ile Xaa 
                325                 330                 335     


Arg Leu Glu Lys Xaa Trp Xaa Ala Leu Arg His Gln Tyr Xaa Gln Xaa 
            340                 345                 350         


Ala Ile Leu Tyr Glu Lys Gln Leu Lys Pro Phe Ser Lys Leu Leu His 
        355                 360                 365             


Glu Gly Arg Glu Ser Xaa Cys Val Pro Pro Asn Asn Val Ser Val Pro 
    370                 375                 380                 


Leu Leu Met Pro Leu Val Xaa Leu Met Glu Arg Gln Ala Val Xaa Phe 
385                 390                 395                 400 


Glu Gly Xaa Asp Met Trp Glu Lys Asn Asp Gln Ser Cys Glu Ile Met 
                405                 410                 415     


Leu Asn His Leu Ala Xaa Ala Arg Phe Met Ala Glu Ala Ala Asp Ser 
            420                 425                 430         


Tyr Arg Met Asn Ala Glu Arg Ile Leu Ala Gly Phe Gln Pro Asp Glu 
        435                 440                 445             


Glu Met Asn Glu Ile Cys Lys Xaa Glu Phe Gln Met Arg Leu Leu Trp 
    450                 455                 460                 


Gly Ser Lys Gly Ala Gln Val Asn Gln Xaa Glu Arg Tyr Glu Lys Phe 
465                 470                 475                 480 


Asn Gln Ile Leu Xaa Ala Leu Ser Arg Lys Leu Glu Pro Pro Pro Val 
                485                 490                 495     


Lys Gln Ala Glu Leu 
            500     


<210> 4051
<211> 156
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(152)
<223> Selenocysteine

<400> 4051
Met Glu Pro Xaa Ala Pro Ser Leu Xaa Glu Glu Asp Leu Xaa Glu Val 
1               5                   10                  15      


Lys Lys Asp Ala Leu Glu Asn Leu Arg Val Tyr Leu Cys Glu Lys Ile 
            20                  25                  30          


Ile Ala Glu Arg His Phe Asp His Leu Arg Ala Lys Lys Ile Leu Ser 
        35                  40                  45              


Arg Glu Asp Xaa Glu Glu Ile Ser Cys Arg Xaa Ser Ser Arg Lys Arg 
    50                  55                  60                  


Ala Gly Lys Leu Leu Asp Tyr Leu Gln Glu Asn Pro Lys Gly Leu Asp 
65                  70                  75                  80  


Xaa Leu Val Glu Ser Ile Arg Arg Glu Lys Xaa Gln Asn Phe Leu Ile 
                85                  90                  95      


Gln Lys Ile Xaa Asp Glu Val Leu Lys Leu Arg Asn Ile Lys Leu Glu 
            100                 105                 110         


His Leu Lys Asp Gly Ala Xaa Asn Asn Leu Ser Arg Ser Asn Ser Asp 
        115                 120                 125             


Glu Ser Asn Phe Ser Glu Lys Leu Arg Ala Ser Xaa Val Met Tyr His 
    130                 135                 140                 


Pro Glu Gly Glu Ser Ser Xaa Xaa Pro Phe Phe Tyr 
145                 150                 155     


<210> 4052
<211> 233
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<400> 4052
Met Glu Pro Xaa Ala Pro Ser Leu Xaa Glu Glu Asp Leu Xaa Glu Val 
1               5                   10                  15      


Lys Lys Asp Ala Leu Glu Asn Leu Arg Val Tyr Leu Cys Glu Lys Ile 
            20                  25                  30          


Ile Ala Glu Arg His Phe Asp His Leu Arg Ala Lys Lys Ile Leu Ser 
        35                  40                  45              


Arg Glu Asp Xaa Glu Glu Ile Ser Cys Arg Xaa Ser Ser Arg Lys Arg 
    50                  55                  60                  


Ala Gly Lys Leu Leu Asp Tyr Leu Gln Glu Asn Pro Lys Gly Leu Asp 
65                  70                  75                  80  


Xaa Leu Val Glu Ser Ile Arg Arg Glu Lys Xaa Gln Asn Phe Leu Ile 
                85                  90                  95      


Gln Lys Ile Xaa Asp Glu Val Leu Lys Leu Arg Asn Ile Lys Leu Glu 
            100                 105                 110         


His Leu Lys Gly Leu Lys Cys Ser Ser Cys Glu Pro Phe Pro Asp Gly 
        115                 120                 125             


Ala Xaa Asn Asn Leu Ser Arg Ser Asn Ser Asp Glu Ser Asn Phe Ser 
    130                 135                 140                 


Glu Lys Leu Arg Ala Ser Xaa Val Met Tyr His Pro Glu Gly Glu Ser 
145                 150                 155                 160 


Ser Xaa Xaa Pro Phe Phe Ser Xaa Asn Ser Ser Leu Asn Leu Pro Val 
                165                 170                 175     


Leu Glu Val Gly Arg Xaa Glu Asn Xaa Ile Phe Ser Ser Xaa Xaa Leu 
            180                 185                 190         


Pro Arg Pro Gly Asp Pro Gly Ala Pro Pro Leu Pro Pro Asp Leu Gln 
        195                 200                 205             


Leu Glu Glu Glu Gly Xaa Cys Ala Asn Ser Ser Glu Met Phe Leu Pro 
    210                 215                 220                 


Leu Arg Ser Arg Xaa Val Ser Arg Gln 
225                 230             


<210> 4053
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 4053
Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile Glu His Lys Arg 
1               5                   10                  15      


Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala Val Asp Lys Pro 
            20                  25                  30          


Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser Asn Pro Val Glu 
        35                  40                  45              


Val Gly Ile Gln Val Xaa Pro Glu Asp Asp Asp Cys Leu Ser Xaa Ser 
    50                  55                  60                  


Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala Asp Lys Leu Leu 
65                  70                  75                  80  


His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His Gly Ala Leu Ile 
                85                  90                  95      


Pro Xaa Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln Gly Ile Cys Lys 
            100                 105                 110         


Asp Glu Pro Ser Ser Tyr Xaa Cys Xaa Xaa Cys Lys Gln Pro Phe Xaa 
        115                 120                 125             


Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Xaa His Gly Leu Arg 
    130                 135                 140                 


Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Xaa Pro Arg Val Leu 
145                 150                 155                 160 


His Xaa Pro Pro Phe Gly Val Val Pro Arg Glu Leu Lys Met Cys Gly 
                165                 170                 175     


Ser Phe Arg Met Glu Ala Arg Glu Pro Leu Ser Ser Glu Lys Ile 
            180                 185                 190     


<210> 4054
<211> 142
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<400> 4054
Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Xaa Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Xaa Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Xaa Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Xaa Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Ala Gln Xaa Glu Leu Glu Asp Val Phe Val Tyr Leu Met Val 
    130                 135                 140         


<210> 4055
<211> 773
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<400> 4055
Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Xaa Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Xaa Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Xaa Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Xaa Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His 
    130                 135                 140                 


Gly Ala Leu Ile Pro Xaa Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln 
145                 150                 155                 160 


Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Xaa Cys Xaa Xaa Cys Lys 
                165                 170                 175     


Gln Pro Phe Xaa Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Xaa 
            180                 185                 190         


His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Xaa 
        195                 200                 205             


Pro Arg Val Gly Ile Pro Ser Gly Leu Gly Ala Glu Cys Pro Ser Gln 
    210                 215                 220                 


Pro Pro Leu His Gly Ile His Ile Ala Asp Asn Asn Pro Phe Asn Leu 
225                 230                 235                 240 


Leu Arg Ile Pro Gly Ser Val Ser Arg Glu Ala Ser Gly Leu Ala Glu 
                245                 250                 255     


Gly Arg Phe Pro Pro Xaa Pro Pro Leu Phe Ser Pro Pro Pro Arg His 
            260                 265                 270         


His Leu Asp Pro His Arg Ile Glu Arg Leu Gly Ala Glu Glu Met Ala 
        275                 280                 285             


Leu Ala Xaa His His Pro Ser Ala Phe Asp Arg Val Leu Arg Leu Asn 
    290                 295                 300                 


Pro Met Ala Met Glu Pro Pro Ala Met Asp Phe Ser Arg Arg Leu Arg 
305                 310                 315                 320 


Glu Leu Ala Gly Asn Xaa Ser Ser Pro Pro Leu Ser Pro Gly Arg Pro 
                325                 330                 335     


Ser Pro Met Gln Arg Leu Leu Gln Pro Phe Gln Pro Gly Ser Lys Pro 
            340                 345                 350         


Pro Phe Leu Ala Xaa Pro Pro Leu Pro Pro Leu Gln Ser Ala Pro Pro 
        355                 360                 365             


Pro Ser Gln Pro Pro Val Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys 
    370                 375                 380                 


Xaa Phe Lys Phe Gln Ser Asn Leu Val Val His Arg Arg Ser His Xaa 
385                 390                 395                 400 


Gly Glu Lys Pro Tyr Lys Cys Asn Leu Cys Asp His Ala Cys Xaa Gln 
                405                 410                 415     


Ala Ser Lys Leu Lys Arg His Met Lys Xaa His Met His Lys Ser Ser 
            420                 425                 430         


Pro Met Xaa Val Lys Ser Asp Asp Gly Leu Ser Xaa Ala Ser Ser Pro 
        435                 440                 445             


Glu Pro Gly Xaa Ser Asp Leu Val Gly Ser Ala Ser Ser Ala Leu Lys 
    450                 455                 460                 


Ser Val Val Ala Lys Phe Lys Ser Glu Asn Asp Pro Asn Leu Ile Pro 
465                 470                 475                 480 


Glu Asn Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu 
                485                 490                 495     


Glu Glu Glu Glu Glu Glu Glu Glu Leu Xaa Glu Ser Glu Arg Val Asp 
            500                 505                 510         


Tyr Gly Phe Gly Leu Ser Leu Glu Ala Ala Arg His His Glu Asn Ser 
        515                 520                 525             


Ser Arg Gly Ala Val Val Gly Val Gly Asp Glu Ser Arg Ala Leu Pro 
    530                 535                 540                 


Asp Val Met Gln Gly Met Val Leu Ser Ser Met Gln His Phe Ser Glu 
545                 550                 555                 560 


Ala Phe His Gln Val Leu Gly Glu Lys His Lys Arg Gly His Leu Ala 
                565                 570                 575     


Glu Ala Glu Gly His Arg Asp Xaa Cys Asp Glu Asp Ser Val Ala Gly 
            580                 585                 590         


Glu Ser Asp Arg Ile Asp Asp Gly Xaa Val Asn Gly Arg Gly Cys Ser 
        595                 600                 605             


Pro Gly Glu Ser Ala Ser Gly Gly Leu Ser Lys Lys Leu Leu Leu Gly 
    610                 615                 620                 


Ser Pro Ser Ser Leu Ser Pro Phe Ser Lys Arg Ile Lys Leu Glu Lys 
625                 630                 635                 640 


Glu Phe Asp Leu Pro Pro Ala Ala Met Pro Asn Xaa Glu Asn Val Tyr 
                645                 650                 655     


Ser Gln Trp Leu Ala Gly Tyr Ala Ala Ser Arg Gln Leu Lys Asp Pro 
            660                 665                 670         


Phe Leu Ser Phe Gly Asp Ser Arg Gln Ser Pro Phe Ala Ser Ser Ser 
        675                 680                 685             


Glu His Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Xaa Pro Pro Gly 
    690                 695                 700                 


Glu Leu Asp Gly Gly Ile Ser Gly Arg Ser Gly Xaa Gly Ser Gly Gly 
705                 710                 715                 720 


Ser Xaa Pro His Ile Ser Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys 
                725                 730                 735     


Glu Gly Arg Arg Ser Asp Xaa Cys Ser Ser His Xaa Pro Ile Arg Arg 
            740                 745                 750         


Ser Xaa Gln Arg Ala Gln Asp Val Trp Gln Phe Ser Asp Gly Ser Ser 
        755                 760                 765             


Arg Ala Leu Lys Phe 
    770             


<210> 4056
<211> 835
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<400> 4056
Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Xaa Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Xaa Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Xaa Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Xaa Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His 
    130                 135                 140                 


Gly Ala Leu Ile Pro Xaa Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln 
145                 150                 155                 160 


Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Xaa Cys Xaa Xaa Cys Lys 
                165                 170                 175     


Gln Pro Phe Xaa Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Xaa 
            180                 185                 190         


His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Xaa 
        195                 200                 205             


Pro Arg Val Gly Ile Pro Ser Gly Leu Gly Ala Glu Cys Pro Ser Gln 
    210                 215                 220                 


Pro Pro Leu His Gly Ile His Ile Ala Asp Asn Asn Pro Phe Asn Leu 
225                 230                 235                 240 


Leu Arg Ile Pro Gly Ser Val Ser Arg Glu Ala Ser Gly Leu Ala Glu 
                245                 250                 255     


Gly Arg Phe Pro Pro Xaa Pro Pro Leu Phe Ser Pro Pro Pro Arg His 
            260                 265                 270         


His Leu Asp Pro His Arg Ile Glu Arg Leu Gly Ala Glu Glu Met Ala 
        275                 280                 285             


Leu Ala Xaa His His Pro Ser Ala Phe Asp Arg Val Leu Arg Leu Asn 
    290                 295                 300                 


Pro Met Ala Met Glu Pro Pro Ala Met Asp Phe Ser Arg Arg Leu Arg 
305                 310                 315                 320 


Glu Leu Ala Gly Asn Xaa Ser Ser Pro Pro Leu Ser Pro Gly Arg Pro 
                325                 330                 335     


Ser Pro Met Gln Arg Leu Leu Gln Pro Phe Gln Pro Gly Ser Lys Pro 
            340                 345                 350         


Pro Phe Leu Ala Xaa Pro Pro Leu Pro Pro Leu Gln Ser Ala Pro Pro 
        355                 360                 365             


Pro Ser Gln Pro Pro Val Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys 
    370                 375                 380                 


Xaa Phe Lys Phe Gln Ser Asn Leu Val Val His Arg Arg Ser His Xaa 
385                 390                 395                 400 


Gly Glu Lys Pro Tyr Lys Cys Asn Leu Cys Asp His Ala Cys Xaa Gln 
                405                 410                 415     


Ala Ser Lys Leu Lys Arg His Met Lys Xaa His Met His Lys Ser Ser 
            420                 425                 430         


Pro Met Xaa Val Lys Ser Asp Asp Gly Leu Ser Xaa Ala Ser Ser Pro 
        435                 440                 445             


Glu Pro Gly Xaa Ser Asp Leu Val Gly Ser Ala Ser Ser Ala Leu Lys 
    450                 455                 460                 


Ser Val Val Ala Lys Phe Lys Ser Glu Asn Asp Pro Asn Leu Ile Pro 
465                 470                 475                 480 


Glu Asn Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu 
                485                 490                 495     


Glu Glu Glu Glu Glu Glu Glu Glu Leu Xaa Glu Ser Glu Arg Val Asp 
            500                 505                 510         


Tyr Gly Phe Gly Leu Ser Leu Glu Ala Ala Arg His His Glu Asn Ser 
        515                 520                 525             


Ser Arg Gly Ala Val Val Gly Val Gly Asp Glu Ser Arg Ala Leu Pro 
    530                 535                 540                 


Asp Val Met Gln Gly Met Val Leu Ser Ser Met Gln His Phe Ser Glu 
545                 550                 555                 560 


Ala Phe His Gln Val Leu Gly Glu Lys His Lys Arg Gly His Leu Ala 
                565                 570                 575     


Glu Ala Glu Gly His Arg Asp Xaa Cys Asp Glu Asp Ser Val Ala Gly 
            580                 585                 590         


Glu Ser Asp Arg Ile Asp Asp Gly Xaa Val Asn Gly Arg Gly Cys Ser 
        595                 600                 605             


Pro Gly Glu Ser Ala Ser Gly Gly Leu Ser Lys Lys Leu Leu Leu Gly 
    610                 615                 620                 


Ser Pro Ser Ser Leu Ser Pro Phe Ser Lys Arg Ile Lys Leu Glu Lys 
625                 630                 635                 640 


Glu Phe Asp Leu Pro Pro Ala Ala Met Pro Asn Xaa Glu Asn Val Tyr 
                645                 650                 655     


Ser Gln Trp Leu Ala Gly Tyr Ala Ala Ser Arg Gln Leu Lys Asp Pro 
            660                 665                 670         


Phe Leu Ser Phe Gly Asp Ser Arg Gln Ser Pro Phe Ala Ser Ser Ser 
        675                 680                 685             


Glu His Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Xaa Pro Pro Gly 
    690                 695                 700                 


Glu Leu Asp Gly Gly Ile Ser Gly Arg Ser Gly Xaa Gly Ser Gly Gly 
705                 710                 715                 720 


Ser Xaa Pro His Ile Ser Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys 
                725                 730                 735     


Glu Gly Arg Arg Ser Asp Xaa Cys Glu Tyr Cys Gly Lys Val Phe Lys 
            740                 745                 750         


Asn Cys Ser Asn Leu Xaa Val His Arg Arg Ser His Xaa Gly Glu Arg 
        755                 760                 765             


Pro Tyr Lys Cys Glu Leu Cys Asn Tyr Ala Cys Ala Gln Ser Ser Lys 
    770                 775                 780                 


Leu Xaa Arg His Met Lys Xaa His Gly Gln Val Gly Lys Asp Val Tyr 
785                 790                 795                 800 


Lys Cys Glu Ile Cys Lys Met Pro Phe Ser Val Tyr Ser Xaa Leu Glu 
                805                 810                 815     


Lys His Met Lys Lys Trp His Ser Asp Arg Val Leu Asn Asn Asp Ile 
            820                 825                 830         


Lys Xaa Glu 
        835 


<210> 4057
<211> 243
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<400> 4057
Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Xaa Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Xaa Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Xaa Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Xaa Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His 
    130                 135                 140                 


Gly Ala Leu Ile Pro Xaa Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln 
145                 150                 155                 160 


Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Xaa Cys Xaa Xaa Cys Lys 
                165                 170                 175     


Gln Pro Phe Xaa Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Xaa 
            180                 185                 190         


His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Xaa 
        195                 200                 205             


Pro Arg Val Leu His Xaa Pro Pro Phe Gly Val Val Pro Arg Glu Leu 
    210                 215                 220                 


Lys Met Cys Gly Ser Phe Arg Met Glu Ala Arg Glu Pro Leu Ser Ser 
225                 230                 235                 240 


Glu Lys Ile 
            


<210> 4058
<211> 801
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<400> 4058
Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Xaa Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Xaa Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Xaa Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Xaa Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Gly Lys Asp Glu Pro Ser Ser Tyr Xaa Cys Xaa Xaa Cys Lys Gln Pro 
    130                 135                 140                 


Phe Xaa Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Xaa His Gly 
145                 150                 155                 160 


Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Xaa Pro Arg 
                165                 170                 175     


Val Gly Ile Pro Ser Gly Leu Gly Ala Glu Cys Pro Ser Gln Pro Pro 
            180                 185                 190         


Leu His Gly Ile His Ile Ala Asp Asn Asn Pro Phe Asn Leu Leu Arg 
        195                 200                 205             


Ile Pro Gly Ser Val Ser Arg Glu Ala Ser Gly Leu Ala Glu Gly Arg 
    210                 215                 220                 


Phe Pro Pro Xaa Pro Pro Leu Phe Ser Pro Pro Pro Arg His His Leu 
225                 230                 235                 240 


Asp Pro His Arg Ile Glu Arg Leu Gly Ala Glu Glu Met Ala Leu Ala 
                245                 250                 255     


Xaa His His Pro Ser Ala Phe Asp Arg Val Leu Arg Leu Asn Pro Met 
            260                 265                 270         


Ala Met Glu Pro Pro Ala Met Asp Phe Ser Arg Arg Leu Arg Glu Leu 
        275                 280                 285             


Ala Gly Asn Xaa Ser Ser Pro Pro Leu Ser Pro Gly Arg Pro Ser Pro 
    290                 295                 300                 


Met Gln Arg Leu Leu Gln Pro Phe Gln Pro Gly Ser Lys Pro Pro Phe 
305                 310                 315                 320 


Leu Ala Xaa Pro Pro Leu Pro Pro Leu Gln Ser Ala Pro Pro Pro Ser 
                325                 330                 335     


Gln Pro Pro Val Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys Xaa Phe 
            340                 345                 350         


Lys Phe Gln Ser Asn Leu Val Val His Arg Arg Ser His Xaa Gly Glu 
        355                 360                 365             


Lys Pro Tyr Lys Cys Asn Leu Cys Asp His Ala Cys Xaa Gln Ala Ser 
    370                 375                 380                 


Lys Leu Lys Arg His Met Lys Xaa His Met His Lys Ser Ser Pro Met 
385                 390                 395                 400 


Xaa Val Lys Ser Asp Asp Gly Leu Ser Xaa Ala Ser Ser Pro Glu Pro 
                405                 410                 415     


Gly Xaa Ser Asp Leu Val Gly Ser Ala Ser Ser Ala Leu Lys Ser Val 
            420                 425                 430         


Val Ala Lys Phe Lys Ser Glu Asn Asp Pro Asn Leu Ile Pro Glu Asn 
        435                 440                 445             


Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu 
    450                 455                 460                 


Glu Glu Glu Glu Glu Glu Leu Xaa Glu Ser Glu Arg Val Asp Tyr Gly 
465                 470                 475                 480 


Phe Gly Leu Ser Leu Glu Ala Ala Arg His His Glu Asn Ser Ser Arg 
                485                 490                 495     


Gly Ala Val Val Gly Val Gly Asp Glu Ser Arg Ala Leu Pro Asp Val 
            500                 505                 510         


Met Gln Gly Met Val Leu Ser Ser Met Gln His Phe Ser Glu Ala Phe 
        515                 520                 525             


His Gln Val Leu Gly Glu Lys His Lys Arg Gly His Leu Ala Glu Ala 
    530                 535                 540                 


Glu Gly His Arg Asp Xaa Cys Asp Glu Asp Ser Val Ala Gly Glu Ser 
545                 550                 555                 560 


Asp Arg Ile Asp Asp Gly Xaa Val Asn Gly Arg Gly Cys Ser Pro Gly 
                565                 570                 575     


Glu Ser Ala Ser Gly Gly Leu Ser Lys Lys Leu Leu Leu Gly Ser Pro 
            580                 585                 590         


Ser Ser Leu Ser Pro Phe Ser Lys Arg Ile Lys Leu Glu Lys Glu Phe 
        595                 600                 605             


Asp Leu Pro Pro Ala Ala Met Pro Asn Xaa Glu Asn Val Tyr Ser Gln 
    610                 615                 620                 


Trp Leu Ala Gly Tyr Ala Ala Ser Arg Gln Leu Lys Asp Pro Phe Leu 
625                 630                 635                 640 


Ser Phe Gly Asp Ser Arg Gln Ser Pro Phe Ala Ser Ser Ser Glu His 
                645                 650                 655     


Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Xaa Pro Pro Gly Glu Leu 
            660                 665                 670         


Asp Gly Gly Ile Ser Gly Arg Ser Gly Xaa Gly Ser Gly Gly Ser Xaa 
        675                 680                 685             


Pro His Ile Ser Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys Glu Gly 
    690                 695                 700                 


Arg Arg Ser Asp Xaa Cys Glu Tyr Cys Gly Lys Val Phe Lys Asn Cys 
705                 710                 715                 720 


Ser Asn Leu Xaa Val His Arg Arg Ser His Xaa Gly Glu Arg Pro Tyr 
                725                 730                 735     


Lys Cys Glu Leu Cys Asn Tyr Ala Cys Ala Gln Ser Ser Lys Leu Xaa 
            740                 745                 750         


Arg His Met Lys Xaa His Gly Gln Val Gly Lys Asp Val Tyr Lys Cys 
        755                 760                 765             


Glu Ile Cys Lys Met Pro Phe Ser Val Tyr Ser Xaa Leu Glu Lys His 
    770                 775                 780                 


Met Lys Lys Trp His Ser Asp Arg Val Leu Asn Asn Asp Ile Lys Xaa 
785                 790                 795                 800 


Glu 
    


<210> 4059
<211> 167
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<400> 4059
Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Xaa Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Xaa Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Xaa Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Xaa Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Gly Asn Pro Arg Gly Ser Ser Glu Lys Ser Pro Gly Cys Gln Cys Lys 
    130                 135                 140                 


Gly Pro Ala Leu Ser Pro Arg Arg Pro Ser Gly Lys Cys Xaa Gly Leu 
145                 150                 155                 160 


Gln Leu Phe Pro Arg Pro Leu 
                165         


<210> 4060
<211> 17
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<400> 4060
Xaa Lys Lys Trp His Ser Asp Arg Val Leu Asn Asn Asp Ile Lys Xaa 
1               5                   10                  15      


Glu 
    


<210> 4061
<211> 823
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<400> 4061
Met Ser Arg Arg Lys Gln Gly Asn Pro Gln His Leu Ser Gln Arg Glu 
1               5                   10                  15      


Leu Ile Xaa Pro Glu Ala Asp His Val Glu Ala Ala Ile Leu Glu Glu 
            20                  25                  30          


Asp Glu Gly Leu Glu Ile Glu Glu Pro Ser Gly Leu Gly Leu Met Val 
        35                  40                  45              


Gly Gly Pro Asp Pro Asp Leu Leu Xaa Cys Gly Gln Cys Gln Met Asn 
    50                  55                  60                  


Phe Pro Leu Gly Asp Ile Leu Val Phe Ile Glu His Lys Arg Lys Gln 
65                  70                  75                  80  


Cys Gly Gly Ser Leu Gly Ala Cys Tyr Asp Lys Ala Leu Asp Lys Asp 
                85                  90                  95      


Ser Pro Pro Pro Ser Ser Arg Ser Glu Leu Arg Lys Val Ser Glu Pro 
            100                 105                 110         


Val Glu Ile Gly Ile Gln Val Xaa Pro Asp Glu Asp Asp His Leu Leu 
        115                 120                 125             


Ser Pro Xaa Lys Gly Ile Cys Pro Lys Gln Glu Asn Ile Ala Gly Lys 
    130                 135                 140                 


Asp Glu Pro Ser Ser Tyr Ile Cys Xaa Xaa Cys Lys Gln Pro Phe Asn 
145                 150                 155                 160 


Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Xaa His Gly Phe Arg 
                165                 170                 175     


Ile Tyr Leu Glu Pro Gly Pro Ala Ser Ser Ser Leu Xaa Pro Arg Leu 
            180                 185                 190         


Xaa Ile Pro Pro Pro Leu Gly Pro Glu Ala Val Ala Gln Ser Pro Leu 
        195                 200                 205             


Met Asn Phe Leu Gly Asp Ser Asn Pro Phe Asn Leu Leu Arg Met Xaa 
    210                 215                 220                 


Gly Pro Ile Leu Arg Asp His Pro Gly Phe Gly Glu Gly Arg Leu Pro 
225                 230                 235                 240 


Gly Xaa Pro Pro Leu Phe Ser Pro Pro Pro Arg His His Leu Asp Pro 
                245                 250                 255     


His Arg Leu Ser Ala Glu Glu Met Gly Leu Val Ala Gln His Pro Ser 
            260                 265                 270         


Ala Phe Asp Arg Val Met Arg Leu Asn Pro Met Ala Ile Asp Ser Pro 
        275                 280                 285             


Ala Met Asp Phe Ser Arg Arg Leu Arg Glu Leu Ala Gly Asn Ser Ser 
    290                 295                 300                 


Xaa Pro Pro Pro Val Ser Pro Gly Arg Gly Asn Pro Met His Arg Leu 
305                 310                 315                 320 


Leu Asn Pro Phe Gln Pro Ser Pro Lys Ser Pro Phe Leu Ser Xaa Pro 
                325                 330                 335     


Pro Leu Pro Pro Met Pro Pro Gly Gly Xaa Pro Pro Pro Gln Pro Pro 
            340                 345                 350         


Ala Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys Xaa Phe Lys Phe Gln 
        355                 360                 365             


Ser Asn Leu Ile Val His Arg Arg Ser His Xaa Gly Glu Lys Pro Tyr 
    370                 375                 380                 


Lys Cys Gln Leu Cys Asp His Ala Cys Ser Gln Ala Ser Lys Leu Lys 
385                 390                 395                 400 


Arg His Met Lys Xaa His Met His Lys Ala Gly Ser Leu Ala Gly Arg 
                405                 410                 415     


Ser Asp Asp Gly Leu Ser Ala Ala Ser Ser Pro Glu Pro Gly Xaa Ser 
            420                 425                 430         


Glu Leu Ala Gly Glu Gly Leu Lys Ala Ala Asp Gly Asp Phe Arg His 
        435                 440                 445             


His Glu Ser Asp Pro Ser Leu Gly His Glu Pro Glu Glu Glu Asp Glu 
    450                 455                 460                 


Glu Glu Glu Glu Glu Glu Glu Glu Leu Leu Leu Glu Asn Glu Ser Arg 
465                 470                 475                 480 


Pro Glu Ser Ser Phe Ser Met Asp Ser Glu Leu Ser Arg Asn Arg Glu 
                485                 490                 495     


Asn Gly Gly Gly Gly Val Pro Gly Val Pro Gly Ala Gly Gly Gly Ala 
            500                 505                 510         


Ala Lys Ala Leu Ala Asp Glu Lys Ala Leu Val Leu Gly Lys Val Met 
        515                 520                 525             


Glu Asn Val Gly Leu Gly Ala Leu Pro Gln Tyr Gly Glu Leu Leu Ala 
    530                 535                 540                 


Asp Lys Gln Lys Arg Gly Ala Phe Leu Lys Arg Ala Ala Gly Gly Gly 
545                 550                 555                 560 


Asp Ala Gly Asp Asp Asp Asp Ala Gly Gly Cys Gly Asp Ala Gly Ala 
                565                 570                 575     


Gly Gly Ala Val Asn Gly Arg Gly Gly Gly Phe Ala Pro Gly Xaa Glu 
            580                 585                 590         


Pro Phe Pro Gly Leu Phe Pro Arg Lys Pro Ala Pro Leu Pro Ser Pro 
        595                 600                 605             


Gly Leu Asn Ser Ala Ala Lys Arg Ile Lys Val Glu Lys Asp Leu Glu 
    610                 615                 620                 


Leu Pro Pro Ala Ala Leu Ile Pro Ser Glu Asn Val Tyr Ser Gln Trp 
625                 630                 635                 640 


Leu Val Gly Tyr Ala Ala Ser Arg His Phe Met Lys Asp Pro Phe Leu 
                645                 650                 655     


Gly Phe Xaa Asp Ala Arg Gln Ser Pro Phe Ala Xaa Ser Ser Glu His 
            660                 665                 670         


Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Xaa Pro Pro Gly Asp Leu 
        675                 680                 685             


Leu Asp Gly Gly Leu Ser Gly Arg Ser Gly Xaa Ala Ser Gly Gly Ser 
    690                 695                 700                 


Xaa Pro His Leu Gly Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys Glu 
705                 710                 715                 720 


Gly Arg Arg Ser Asp Xaa Cys Glu Tyr Cys Gly Lys Val Phe Lys Asn 
                725                 730                 735     


Cys Ser Asn Leu Xaa Val His Arg Arg Ser His Xaa Gly Glu Arg Pro 
            740                 745                 750         


Tyr Lys Cys Glu Leu Cys Asn Tyr Ala Cys Ala Gln Ser Ser Lys Leu 
        755                 760                 765             


Xaa Arg His Met Lys Xaa His Gly Gln Ile Gly Lys Glu Val Tyr Arg 
    770                 775                 780                 


Cys Asp Ile Cys Gln Met Pro Phe Ser Val Tyr Ser Xaa Leu Glu Lys 
785                 790                 795                 800 


His Met Lys Lys Trp His Gly Glu His Leu Leu Xaa Asn Asp Val Lys 
                805                 810                 815     


Ile Glu Gln Ala Glu Arg Ser 
            820             


<210> 4062
<211> 894
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<400> 4062
Met Ser Arg Arg Lys Gln Gly Asn Pro Gln His Leu Ser Gln Arg Glu 
1               5                   10                  15      


Leu Ile Xaa Pro Glu Ala Asp His Val Glu Ala Ala Ile Leu Glu Glu 
            20                  25                  30          


Asp Glu Gly Leu Glu Ile Glu Glu Pro Ser Gly Leu Gly Leu Met Val 
        35                  40                  45              


Gly Gly Pro Asp Pro Asp Leu Leu Xaa Cys Gly Gln Cys Gln Met Asn 
    50                  55                  60                  


Phe Pro Leu Gly Asp Ile Leu Val Phe Ile Glu His Lys Arg Lys Gln 
65                  70                  75                  80  


Cys Gly Gly Ser Leu Gly Ala Cys Tyr Asp Lys Ala Leu Asp Lys Asp 
                85                  90                  95      


Ser Pro Pro Pro Ser Ser Arg Ser Glu Leu Arg Lys Val Ser Glu Pro 
            100                 105                 110         


Val Glu Ile Gly Ile Gln Val Xaa Pro Asp Glu Asp Asp His Leu Leu 
        115                 120                 125             


Ser Pro Xaa Lys Gly Ile Cys Pro Lys Gln Glu Asn Ile Ala Gly Pro 
    130                 135                 140                 


Cys Arg Pro Ala Gln Leu Pro Ala Val Ala Pro Ile Ala Ala Ser Ser 
145                 150                 155                 160 


His Pro His Ser Ser Val Ile Xaa Ser Pro Leu Arg Ala Leu Gly Ala 
                165                 170                 175     


Leu Pro Pro Cys Leu Pro Leu Pro Cys Cys Ser Ala Arg Pro Val Ser 
            180                 185                 190         


Gly Asp Gly Xaa Gln Gly Glu Gly Gln Xaa Glu Ala Pro Phe Gly Cys 
        195                 200                 205             


Gln Cys Gln Leu Ser Gly Lys Asp Glu Pro Ser Ser Tyr Ile Cys Xaa 
    210                 215                 220                 


Xaa Cys Lys Gln Pro Phe Asn Ser Ala Trp Phe Leu Leu Gln His Ala 
225                 230                 235                 240 


Gln Asn Xaa His Gly Phe Arg Ile Tyr Leu Glu Pro Gly Pro Ala Ser 
                245                 250                 255     


Ser Ser Leu Xaa Pro Arg Leu Xaa Ile Pro Pro Pro Leu Gly Pro Glu 
            260                 265                 270         


Ala Val Ala Gln Ser Pro Leu Met Asn Phe Leu Gly Asp Ser Asn Pro 
        275                 280                 285             


Phe Asn Leu Leu Arg Met Xaa Gly Pro Ile Leu Arg Asp His Pro Gly 
    290                 295                 300                 


Phe Gly Glu Gly Arg Leu Pro Gly Xaa Pro Pro Leu Phe Ser Pro Pro 
305                 310                 315                 320 


Pro Arg His His Leu Asp Pro His Arg Leu Ser Ala Glu Glu Met Gly 
                325                 330                 335     


Leu Val Ala Gln His Pro Ser Ala Phe Asp Arg Val Met Arg Leu Asn 
            340                 345                 350         


Pro Met Ala Ile Asp Ser Pro Ala Met Asp Phe Ser Arg Arg Leu Arg 
        355                 360                 365             


Glu Leu Ala Gly Asn Ser Ser Xaa Pro Pro Pro Val Ser Pro Gly Arg 
    370                 375                 380                 


Gly Asn Pro Met His Arg Leu Leu Asn Pro Phe Gln Pro Ser Pro Lys 
385                 390                 395                 400 


Ser Pro Phe Leu Ser Xaa Pro Pro Leu Pro Pro Met Pro Pro Gly Gly 
                405                 410                 415     


Xaa Pro Pro Pro Gln Pro Pro Ala Lys Ser Lys Ser Cys Glu Phe Cys 
            420                 425                 430         


Gly Lys Xaa Phe Lys Phe Gln Ser Asn Leu Ile Val His Arg Arg Ser 
        435                 440                 445             


His Xaa Gly Glu Lys Pro Tyr Lys Cys Gln Leu Cys Asp His Ala Cys 
    450                 455                 460                 


Ser Gln Ala Ser Lys Leu Lys Arg His Met Lys Xaa His Met His Lys 
465                 470                 475                 480 


Ala Gly Ser Leu Ala Gly Arg Ser Asp Asp Gly Leu Ser Ala Ala Ser 
                485                 490                 495     


Ser Pro Glu Pro Gly Xaa Ser Glu Leu Ala Gly Glu Gly Leu Lys Ala 
            500                 505                 510         


Ala Asp Gly Asp Phe Arg His His Glu Ser Asp Pro Ser Leu Gly His 
        515                 520                 525             


Glu Pro Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Leu 
    530                 535                 540                 


Leu Leu Glu Asn Glu Ser Arg Pro Glu Ser Ser Phe Ser Met Asp Ser 
545                 550                 555                 560 


Glu Leu Ser Arg Asn Arg Glu Asn Gly Gly Gly Gly Val Pro Gly Val 
                565                 570                 575     


Pro Gly Ala Gly Gly Gly Ala Ala Lys Ala Leu Ala Asp Glu Lys Ala 
            580                 585                 590         


Leu Val Leu Gly Lys Val Met Glu Asn Val Gly Leu Gly Ala Leu Pro 
        595                 600                 605             


Gln Tyr Gly Glu Leu Leu Ala Asp Lys Gln Lys Arg Gly Ala Phe Leu 
    610                 615                 620                 


Lys Arg Ala Ala Gly Gly Gly Asp Ala Gly Asp Asp Asp Asp Ala Gly 
625                 630                 635                 640 


Gly Cys Gly Asp Ala Gly Ala Gly Gly Ala Val Asn Gly Arg Gly Gly 
                645                 650                 655     


Gly Phe Ala Pro Gly Xaa Glu Pro Phe Pro Gly Leu Phe Pro Arg Lys 
            660                 665                 670         


Pro Ala Pro Leu Pro Ser Pro Gly Leu Asn Ser Ala Ala Lys Arg Ile 
        675                 680                 685             


Lys Val Glu Lys Asp Leu Glu Leu Pro Pro Ala Ala Leu Ile Pro Ser 
    690                 695                 700                 


Glu Asn Val Tyr Ser Gln Trp Leu Val Gly Tyr Ala Ala Ser Arg His 
705                 710                 715                 720 


Phe Met Lys Asp Pro Phe Leu Gly Phe Xaa Asp Ala Arg Gln Ser Pro 
                725                 730                 735     


Phe Ala Xaa Ser Ser Glu His Ser Ser Glu Asn Gly Ser Leu Arg Phe 
            740                 745                 750         


Ser Xaa Pro Pro Gly Asp Leu Leu Asp Gly Gly Leu Ser Gly Arg Ser 
        755                 760                 765             


Gly Xaa Ala Ser Gly Gly Ser Xaa Pro His Leu Gly Gly Pro Gly Pro 
    770                 775                 780                 


Gly Arg Pro Ser Ser Lys Glu Gly Arg Arg Ser Asp Xaa Cys Glu Tyr 
785                 790                 795                 800 


Cys Gly Lys Val Phe Lys Asn Cys Ser Asn Leu Xaa Val His Arg Arg 
                805                 810                 815     


Ser His Xaa Gly Glu Arg Pro Tyr Lys Cys Glu Leu Cys Asn Tyr Ala 
            820                 825                 830         


Cys Ala Gln Ser Ser Lys Leu Xaa Arg His Met Lys Xaa His Gly Gln 
        835                 840                 845             


Ile Gly Lys Glu Val Tyr Arg Cys Asp Ile Cys Gln Met Pro Phe Ser 
    850                 855                 860                 


Val Tyr Ser Xaa Leu Glu Lys His Met Lys Lys Trp His Gly Glu His 
865                 870                 875                 880 


Leu Leu Xaa Asn Asp Val Lys Ile Glu Gln Ala Glu Arg Ser 
                885                 890                 


<210> 4063
<211> 700
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<400> 4063
Met Ser Arg Arg Lys Gln Gly Asn Pro Gln His Leu Ser Gln Arg Glu 
1               5                   10                  15      


Leu Ile Xaa Arg Lys Asp Glu Pro Ser Ser Tyr Ile Cys Xaa Xaa Cys 
            20                  25                  30          


Lys Gln Pro Phe Asn Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn 
        35                  40                  45              


Xaa His Gly Phe Arg Ile Tyr Leu Glu Pro Gly Pro Ala Ser Ser Ser 
    50                  55                  60                  


Leu Xaa Pro Arg Leu Xaa Ile Pro Pro Pro Leu Gly Pro Glu Ala Val 
65                  70                  75                  80  


Ala Gln Ser Pro Leu Met Asn Phe Leu Gly Asp Ser Asn Pro Phe Asn 
                85                  90                  95      


Leu Leu Arg Met Xaa Gly Pro Ile Leu Arg Asp His Pro Gly Phe Gly 
            100                 105                 110         


Glu Gly Arg Leu Pro Gly Xaa Pro Pro Leu Phe Ser Pro Pro Pro Arg 
        115                 120                 125             


His His Leu Asp Pro His Arg Leu Ser Ala Glu Glu Met Gly Leu Val 
    130                 135                 140                 


Ala Gln His Pro Ser Ala Phe Asp Arg Val Met Arg Leu Asn Pro Met 
145                 150                 155                 160 


Ala Ile Asp Ser Pro Ala Met Asp Phe Ser Arg Arg Leu Arg Glu Leu 
                165                 170                 175     


Ala Gly Asn Ser Ser Xaa Pro Pro Pro Val Ser Pro Gly Arg Gly Asn 
            180                 185                 190         


Pro Met His Arg Leu Leu Asn Pro Phe Gln Pro Ser Pro Lys Ser Pro 
        195                 200                 205             


Phe Leu Ser Xaa Pro Pro Leu Pro Pro Met Pro Pro Gly Gly Xaa Pro 
    210                 215                 220                 


Pro Pro Gln Pro Pro Ala Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys 
225                 230                 235                 240 


Xaa Phe Lys Phe Gln Ser Asn Leu Ile Val His Arg Arg Ser His Xaa 
                245                 250                 255     


Gly Glu Lys Pro Tyr Lys Cys Gln Leu Cys Asp His Ala Cys Ser Gln 
            260                 265                 270         


Ala Ser Lys Leu Lys Arg His Met Lys Xaa His Met His Lys Ala Gly 
        275                 280                 285             


Ser Leu Ala Gly Arg Ser Asp Asp Gly Leu Ser Ala Ala Ser Ser Pro 
    290                 295                 300                 


Glu Pro Gly Xaa Ser Glu Leu Ala Gly Glu Gly Leu Lys Ala Ala Asp 
305                 310                 315                 320 


Gly Asp Phe Arg His His Glu Ser Asp Pro Ser Leu Gly His Glu Pro 
                325                 330                 335     


Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Leu Leu Leu 
            340                 345                 350         


Glu Asn Glu Ser Arg Pro Glu Ser Ser Phe Ser Met Asp Ser Glu Leu 
        355                 360                 365             


Ser Arg Asn Arg Glu Asn Gly Gly Gly Gly Val Pro Gly Val Pro Gly 
    370                 375                 380                 


Ala Gly Gly Gly Ala Ala Lys Ala Leu Ala Asp Glu Lys Ala Leu Val 
385                 390                 395                 400 


Leu Gly Lys Val Met Glu Asn Val Gly Leu Gly Ala Leu Pro Gln Tyr 
                405                 410                 415     


Gly Glu Leu Leu Ala Asp Lys Gln Lys Arg Gly Ala Phe Leu Lys Arg 
            420                 425                 430         


Ala Ala Gly Gly Gly Asp Ala Gly Asp Asp Asp Asp Ala Gly Gly Cys 
        435                 440                 445             


Gly Asp Ala Gly Ala Gly Gly Ala Val Asn Gly Arg Gly Gly Gly Phe 
    450                 455                 460                 


Ala Pro Gly Xaa Glu Pro Phe Pro Gly Leu Phe Pro Arg Lys Pro Ala 
465                 470                 475                 480 


Pro Leu Pro Ser Pro Gly Leu Asn Ser Ala Ala Lys Arg Ile Lys Val 
                485                 490                 495     


Glu Lys Asp Leu Glu Leu Pro Pro Ala Ala Leu Ile Pro Ser Glu Asn 
            500                 505                 510         


Val Tyr Ser Gln Trp Leu Val Gly Tyr Ala Ala Ser Arg His Phe Met 
        515                 520                 525             


Lys Asp Pro Phe Leu Gly Phe Xaa Asp Ala Arg Gln Ser Pro Phe Ala 
    530                 535                 540                 


Xaa Ser Ser Glu His Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Xaa 
545                 550                 555                 560 


Pro Pro Gly Asp Leu Leu Asp Gly Gly Leu Ser Gly Arg Ser Gly Xaa 
                565                 570                 575     


Ala Ser Gly Gly Ser Xaa Pro His Leu Gly Gly Pro Gly Pro Gly Arg 
            580                 585                 590         


Pro Ser Ser Lys Glu Gly Arg Arg Ser Asp Xaa Cys Glu Tyr Cys Gly 
        595                 600                 605             


Lys Val Phe Lys Asn Cys Ser Asn Leu Xaa Val His Arg Arg Ser His 
    610                 615                 620                 


Xaa Gly Glu Arg Pro Tyr Lys Cys Glu Leu Cys Asn Tyr Ala Cys Ala 
625                 630                 635                 640 


Gln Ser Ser Lys Leu Xaa Arg His Met Lys Xaa His Gly Gln Ile Gly 
                645                 650                 655     


Lys Glu Val Tyr Arg Cys Asp Ile Cys Gln Met Pro Phe Ser Val Tyr 
            660                 665                 670         


Ser Xaa Leu Glu Lys His Met Lys Lys Trp His Gly Glu His Leu Leu 
        675                 680                 685             


Xaa Asn Asp Val Lys Ile Glu Gln Ala Glu Arg Ser 
    690                 695                 700 


<210> 4064
<211> 239
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<400> 4064
Met Ala His Ala Gly Arg Xaa Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Xaa Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Xaa Ser Pro Leu Gln Xaa Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Xaa 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Xaa Pro Phe Xaa Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Xaa Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Xaa Glu Tyr Leu Asn Arg His Leu His Xaa Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             


Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Xaa Leu Leu Ser Leu Ala 
    210                 215                 220                 


Leu Val Gly Ala Cys Ile Xaa Leu Gly Ala Tyr Leu Gly His Lys 
225                 230                 235                 


<210> 4065
<211> 205
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<400> 4065
Met Ala His Ala Gly Arg Xaa Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Xaa Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Xaa Ser Pro Leu Gln Xaa Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Xaa 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Xaa Pro Phe Xaa Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Xaa Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Xaa Glu Tyr Leu Asn Arg His Leu His Xaa Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Val Gly Ala Leu Gly Asp Val Ser Leu Gly 
        195                 200                 205 


<210> 4066
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<400> 4066
Met Xaa Asp Cys Glu Phe Gly Tyr Ile Tyr Arg Leu Ala Gln Asp Tyr 
1               5                   10                  15      


Leu Gln Cys Val Leu Gln Ile Pro Gln Pro Gly Ser Gly Pro Ser Lys 
            20                  25                  30          


Xaa Ser Arg Val Leu Gln Asn Val Ala Phe Ser Val Gln Lys Glu Val 
        35                  40                  45              


Glu Lys Asn Leu Lys Ser Cys Leu Asp Asn Val Asn Val Val Ser Val 
    50                  55                  60                  


Asp Xaa Ala Arg Xaa Leu Phe Asn Gln Val Met Glu Lys Glu Phe Glu 
65                  70                  75                  80  


Asp Gly Ile Ile Asn Trp Gly Arg Ile Val Xaa Ile Phe Ala Phe Glu 
                85                  90                  95      


Gly Ile Leu Ile Lys Lys Leu Leu Arg Gln Gln Ile Ala Pro Asp Val 
            100                 105                 110         


Asp Xaa Tyr Lys Glu Ile Ser Tyr Phe Val Ala Glu Phe Ile Met Asn 
        115                 120                 125             


Asn Xaa Gly Glu Trp Ile Arg Gln Asn Gly Gly Trp Glu Asn Gly Phe 
    130                 135                 140                 


Val Lys Lys Phe Glu Pro Lys Ser Gly Trp Met Xaa Phe Leu Glu Val 
145                 150                 155                 160 


Xaa Gly Lys Ile Cys Glu Met Leu Ser Leu Leu Lys Gln Tyr Cys 
                165                 170                 175 


<210> 4067
<211> 163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<400> 4067
Met Xaa Asp Cys Glu Phe Gly Tyr Ile Tyr Arg Leu Ala Gln Asp Tyr 
1               5                   10                  15      


Leu Gln Cys Val Leu Gln Ile Pro Gln Pro Gly Ser Gly Pro Ser Lys 
            20                  25                  30          


Xaa Ser Arg Val Leu Gln Asn Val Ala Phe Ser Val Gln Lys Glu Val 
        35                  40                  45              


Glu Lys Asn Leu Lys Ser Cys Leu Asp Asn Val Asn Val Val Ser Val 
    50                  55                  60                  


Asp Xaa Ala Arg Xaa Leu Phe Asn Gln Val Met Glu Lys Glu Phe Glu 
65                  70                  75                  80  


Asp Gly Ile Ile Asn Trp Gly Arg Ile Val Xaa Ile Phe Ala Phe Glu 
                85                  90                  95      


Gly Ile Leu Ile Lys Lys Leu Leu Arg Gln Gln Ile Ala Pro Asp Val 
            100                 105                 110         


Asp Xaa Tyr Lys Glu Ile Ser Tyr Phe Val Ala Glu Phe Ile Met Asn 
        115                 120                 125             


Asn Xaa Gly Glu Trp Ile Arg Gln Asn Gly Gly Trp Gly Lys Trp His 
    130                 135                 140                 


Asn His Xaa Pro Met Leu Val Glu Ser Val Ala His Lys Lys Arg Lys 
145                 150                 155                 160 


Met Ala Leu 
            


<210> 4068
<211> 48
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<400> 4068
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Xaa Glu Ala Pro Glu Gly Xaa Glu Ser Glu Met Glu Xaa Pro 
        35                  40                  45              


<210> 4069
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<400> 4069
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Xaa Glu Ala Pro Glu Gly Xaa Glu Ser Glu Met Glu Xaa Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Xaa Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Xaa Ser Gln Leu 
            100                 105                 110         


His Ile Xaa Pro Gly Xaa Ala Tyr Gln Ser Phe Glu Gln Asp Xaa Phe 
        115                 120                 125             


Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln 
    130                 135                 140                 


Glu Arg Phe Asn Arg Trp Phe Leu Xaa Gly Met Xaa Val Ala Gly Val 
145                 150                 155                 160 


Val Leu Leu Gly Ser Leu Phe Ser Arg Lys 
                165                 170 


<210> 4070
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<400> 4070
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Xaa Glu Ala Pro Glu Gly Xaa Glu Ser Glu Met Glu Xaa Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Xaa Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Xaa Ser Gln Leu 
            100                 105                 110         


His Ile Xaa Pro Gly Xaa Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             


Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 


Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 


Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Xaa Tyr Leu Asn Asp 
                165                 170                 175     


His Leu Glu Pro Trp 
            180     


<210> 4071
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<400> 4071
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Xaa Glu Ala Pro Glu Gly Xaa Glu Ser Glu Met Glu Xaa Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Xaa Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Xaa Ser Gln Leu 
            100                 105                 110         


His Ile Xaa Pro Gly Xaa Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             


Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 


Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 


Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Xaa Tyr Leu Asn Asp 
                165                 170                 175     


His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp 
            180                 185             


<210> 4072
<211> 205
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<400> 4072
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Xaa Glu Ala Pro Glu Gly Xaa Glu Ser Glu Met Glu Xaa Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Xaa Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Xaa Ser Gln Leu 
            100                 105                 110         


His Ile Xaa Pro Gly Xaa Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             


Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 


Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 


Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Xaa Tyr Leu Asn Asp 
                165                 170                 175     


His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Xaa Phe Val 
            180                 185                 190         


Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys 
        195                 200                 205 


<210> 4073
<211> 233
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<400> 4073
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Xaa Glu Ala Pro Glu Gly Xaa Glu Ser Glu Met Glu Xaa Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Xaa Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Xaa Ser Gln Leu 
            100                 105                 110         


His Ile Xaa Pro Gly Xaa Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             


Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 


Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 


Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Xaa Tyr Leu Asn Asp 
                165                 170                 175     


His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Xaa Phe Val 
            180                 185                 190         


Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
        195                 200                 205             


Arg Phe Asn Arg Trp Phe Leu Xaa Gly Met Xaa Val Ala Gly Val Val 
    210                 215                 220                 


Leu Leu Gly Ser Leu Phe Ser Arg Lys 
225                 230             


<210> 4074
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<400> 4074
Met Val Asp Gln Leu Arg Glu Arg Xaa Xaa Met Ala Asp Pro Leu Arg 
1               5                   10                  15      


Glu Arg Xaa Glu Leu Leu Leu Ala Asp Tyr Leu Gly Tyr Cys Ala Arg 
            20                  25                  30          


Glu Pro Gly Xaa Pro Glu Pro Ala Pro Ser Xaa Pro Glu Ala Ala Val 
        35                  40                  45              


Leu Arg Ser Ala Ala Ala Arg Leu Arg Gln Ile His Arg Ser Phe Phe 
    50                  55                  60                  


Ser Ala Tyr Leu Gly Tyr Pro Gly Asn Arg Phe Glu Leu Val Ala Leu 
65                  70                  75                  80  


Met Ala Asp Ser Val Leu Ser Asp Ser Pro Gly Pro Xaa Trp Gly Arg 
                85                  90                  95      


Val Val Xaa Leu Val Xaa Phe Ala Gly Xaa Leu Leu Glu Arg Gly Pro 
            100                 105                 110         


Leu Val Xaa Ala Arg Trp Lys Lys Trp Gly Phe Gln Pro Arg Leu Lys 
        115                 120                 125             


Glu Gln Glu Gly Asp Val Ala Arg Asp Cys Gln Arg Leu Val Ala Leu 
    130                 135                 140                 


Leu Ser Ser Arg Leu Met Gly Gln His Arg Ala Trp Leu Gln Ala Gln 
145                 150                 155                 160 


Gly Gly Trp Asp Gly Phe Cys His Phe Phe Arg Xaa Pro Phe Pro Leu 
                165                 170                 175     


Ala Phe Trp Arg Lys Gln Leu Val Gln Ala Phe Leu Ser Cys Leu Leu 
            180                 185                 190         


Xaa Xaa Ala Phe Ile Tyr Leu Trp Xaa Arg Leu Leu 
        195                 200                 


<210> 4075
<211> 241
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<400> 4075
Met Val Asp Gln Leu Arg Glu Arg Xaa Xaa Met Ala Asp Pro Leu Arg 
1               5                   10                  15      


Glu Arg Xaa Glu Leu Leu Leu Ala Asp Tyr Leu Gly Tyr Cys Ala Arg 
            20                  25                  30          


Glu Pro Gly Xaa Pro Glu Pro Ala Pro Ser Xaa Pro Glu Ala Ala Val 
        35                  40                  45              


Leu Arg Ser Ala Ala Ala Arg Leu Arg Gln Ile His Arg Ser Phe Phe 
    50                  55                  60                  


Ser Ala Tyr Leu Gly Tyr Pro Gly Asn Arg Phe Glu Leu Val Ala Leu 
65                  70                  75                  80  


Met Ala Asp Ser Val Leu Ser Asp Ser Pro Gly Pro Xaa Trp Gly Arg 
                85                  90                  95      


Val Val Xaa Leu Val Xaa Phe Ala Gly Xaa Leu Leu Glu Arg Gly Pro 
            100                 105                 110         


Leu Val Xaa Ala Arg Trp Lys Lys Trp Gly Phe Gln Pro Arg Leu Lys 
        115                 120                 125             


Glu Gln Glu Gly Asp Val Ala Arg Asp Cys Gln Arg Leu Val Ala Leu 
    130                 135                 140                 


Leu Ser Ser Arg Leu Met Gly Gln His Arg Ala Trp Leu Gln Ala Gln 
145                 150                 155                 160 


Gly Gly Trp Val Ser Xaa Arg Arg Xaa Pro Gly His Gly Ala Gly Arg 
                165                 170                 175     


Ala Ala Gly Lys Arg Pro Arg Gly Trp His Gly Trp Leu Leu Ser Leu 
            180                 185                 190         


Leu Gln Asp Pro Leu Ser Xaa Gly Phe Leu Glu Lys Xaa Ala Gly Pro 
        195                 200                 205             


Gly Phe Ser Val Met Leu Val Asn Asn Ser Leu His Leu Ser Leu Asp 
    210                 215                 220                 


Xaa Ile Ile Met Ser Phe Lys Xaa Phe Asn Pro Leu Leu Pro Ala Gln 
225                 230                 235                 240 


Leu 
    


<210> 4076
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<400> 4076
Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly Arg Gln 
1               5                   10                  15      


Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala Pro Xaa 
            20                  25                  30          


Ser Leu Gln Xaa Glu Pro Gln Asp Arg Ser Pro Ala Pro Met Ser Cys 
        35                  40                  45              


Asp Lys Ser Xaa Gln Xaa Pro Ser Pro Pro Cys Gln Ala Phe Asn His 
    50                  55                  60                  


Tyr Leu Ser Ala Met Asp Asp Ser Ala Gly Ser Ser Leu Arg Ile Ala 
65                  70                  75                  80  


Leu His Arg Glu Val Gln Trp Pro Leu Lys Trp Leu Ala Lys Ser Ser 
                85                  90                  95      


<210> 4077
<211> 85
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<400> 4077
Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Xaa Ser Leu Gln Xaa Glu Pro Gln Ala Ser Met Arg Gln Ala Glu 
        35                  40                  45              


Pro Ala Asp Met Arg Pro Glu Ile Trp Ile Ala Gln Glu Leu Arg Arg 
    50                  55                  60                  


Ile Gly Asp Glu Phe Asn Ala Tyr Tyr Ala Arg Arg Leu Ala Lys Leu 
65                  70                  75                  80  


Leu Ala Ser Ser Xaa 
                85  


<210> 4078
<211> 82
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<400> 4078
Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Xaa Ser Leu Gln Xaa Glu Pro Gln Ala Ser Met Arg Gln Ala Glu 
        35                  40                  45              


Pro Ala Asp Met Arg Pro Glu Ile Trp Ile Ala Gln Glu Leu Arg Arg 
    50                  55                  60                  


Ile Gly Asp Glu Phe Asn Ala Tyr Tyr Ala Arg Arg Met Pro Leu Pro 
65                  70                  75                  80  


Pro Asp 
        


<210> 4079
<211> 109
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<400> 4079
Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Xaa Ser Leu Gln Xaa Glu Pro Gln Asp Arg Ser Pro Ala Pro Met 
        35                  40                  45              


Ser Cys Asp Lys Ser Xaa Gln Xaa Pro Ser Pro Pro Cys Gln Ala Phe 
    50                  55                  60                  


Asn His Tyr Leu Ser Ala Met Ala Ser Met Arg Gln Ala Glu Pro Ala 
65                  70                  75                  80  


Asp Met Arg Pro Glu Ile Trp Ile Ala Gln Glu Leu Arg Arg Ile Gly 
                85                  90                  95      


Asp Glu Phe Asn Ala Tyr Tyr Ala Arg Arg Leu Glu Lys 
            100                 105                 


<210> 4080
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<400> 4080
Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Xaa Ser Leu Gln Xaa Glu Pro Gln Asp Arg Ser Pro Ala Pro Met 
        35                  40                  45              


Ser Cys Asp Lys Ser Xaa Gln Xaa Pro Ser Pro Pro Cys Gln Ala Phe 
    50                  55                  60                  


Asn His Tyr Leu Ser Ala Met Ala Ser Met Arg Gln Ala Glu Pro Ala 
65                  70                  75                  80  


Asp Met Arg Pro Glu Ile Trp Ile Ala Gln Glu Leu Arg Arg Ile Gly 
                85                  90                  95      


Asp Glu Phe Asn Ala Tyr Tyr Ala Arg Arg Val Phe Leu Asn Asn Tyr 
            100                 105                 110         


Gln Ala Ala Glu Asp His Pro Arg Met Val Ile Leu Arg Leu Leu Arg 
        115                 120                 125             


Tyr Ile Val Arg Leu Val Trp Arg Met His 
    130                 135             


<210> 4081
<211> 98
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<400> 4081
Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Xaa Ser Leu Gln Xaa Glu Pro Gln Asp Arg Ser Pro Ala Pro Met 
        35                  40                  45              


Ser Cys Asp Lys Ser Xaa Gln Xaa Pro Ser Pro Pro Cys Gln Ala Phe 
    50                  55                  60                  


Asn His Tyr Leu Ser Ala Met Asp Asp Ser Ala Gly Ser Ser Leu Arg 
65                  70                  75                  80  


Ile Ala Leu His Arg Glu Val Gln Trp Pro Leu Lys Trp Leu Ala Lys 
                85                  90                  95      


Ser Ser 
        


<210> 4082
<211> 80
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<400> 4082
Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Xaa Ser Leu Gln Xaa Glu Pro Gln Asp Arg Ser Pro Ala Pro Met 
        35                  40                  45              


Ser Cys Asp Lys Ser Xaa Gln Xaa Pro Ser Pro Pro Cys Gln Ala Phe 
    50                  55                  60                  


Asn His Tyr Leu Ser Ala Met Val Arg Glu Ile Glu Glu Val Val Val 
65                  70                  75                  80  


<210> 4083
<211> 112
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 4083
Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Xaa Ser Leu Gln Xaa Glu Pro Gln Asp Arg Ser Pro Ala Pro Met 
        35                  40                  45              


Ser Cys Asp Lys Ser Xaa Gln Xaa Pro Ser Pro Pro Cys Gln Ala Phe 
    50                  55                  60                  


Asn His Tyr Leu Ser Ala Met Val Val Ile Leu Glu Asp Ile Gly Asp 
65                  70                  75                  80  


Leu Ser Leu Cys Phe Gly Phe Ile Phe Xaa Gly Leu Asp Leu Tyr Gly 
                85                  90                  95      


His His His Ser Gln Asp Xaa Glu Gln Leu Asn His Lys Asp Phe Ser 
            100                 105                 110         


<210> 4084
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<400> 4084
Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Xaa Ser Leu Gln Xaa Glu Pro Gln Gly Asn Pro Glu Gly Asn His 
        35                  40                  45              


Gly Gly Glu Gly Asp Ser Cys Pro His Gly Ser Pro Gln Gly Pro Leu 
    50                  55                  60                  


Ala Pro Pro Ala Ser Pro Gly Pro 
65                  70          


<210> 4085
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 4085
Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Xaa Ser Leu Gln Xaa Glu Pro Gln Gly Asn Pro Glu Gly Asn His 
        35                  40                  45              


Gly Gly Glu Gly Asp Ser Cys Pro His Gly Ser Pro Gln Gly Pro Leu 
    50                  55                  60                  


Ala Pro Pro Ala Ser Pro Gly Pro Phe Ala Xaa Arg Ser Pro Leu Phe 
65                  70                  75                  80  


Ile Phe Met Arg Arg Ser Ser Leu Leu Ser Arg Ser Ser Ser Gly Tyr 
                85                  90                  95      


Phe Ser Phe Asp Xaa Asp Arg Ser Pro Ala Pro Met Ser Cys Asp Lys 
            100                 105                 110         


Ser Xaa Gln Xaa Pro Ser Pro Pro Cys Gln 
        115                 120         


<210> 4086
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 4086
Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Xaa Ser Leu Gln Xaa Glu Pro Gln Gly Asn Pro Glu Gly Asn His 
        35                  40                  45              


Gly Gly Glu Gly Asp Ser Cys Pro His Gly Ser Pro Gln Gly Pro Leu 
    50                  55                  60                  


Ala Pro Pro Ala Ser Pro Gly Pro Phe Ala Xaa Arg Ser Pro Leu Phe 
65                  70                  75                  80  


Ile Phe Met Arg Arg Ser Ser Leu Leu Ser Arg Ser Ser Ser Gly Tyr 
                85                  90                  95      


Phe Ser Phe Asp Xaa Asp Arg Ser Pro Ala Pro Met Ser Cys Asp Lys 
            100                 105                 110         


Ser Xaa Gln Xaa Pro Ser Pro Pro Cys Gln Ala Phe Asn His Tyr Leu 
        115                 120                 125             


Ser Ala Met Ala Asn Trp Asp 
    130                 135 


<210> 4087
<211> 169
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 4087
Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Xaa Ser Leu Gln Xaa Glu Pro Gln Gly Asn Pro Glu Gly Asn His 
        35                  40                  45              


Gly Gly Glu Gly Asp Ser Cys Pro His Gly Ser Pro Gln Gly Pro Leu 
    50                  55                  60                  


Ala Pro Pro Ala Ser Pro Gly Pro Phe Ala Xaa Arg Ser Pro Leu Phe 
65                  70                  75                  80  


Ile Phe Met Arg Arg Ser Ser Leu Leu Ser Arg Ser Ser Ser Gly Tyr 
                85                  90                  95      


Phe Ser Phe Asp Xaa Asp Arg Ser Pro Ala Pro Met Ser Cys Asp Lys 
            100                 105                 110         


Ser Xaa Gln Xaa Pro Ser Pro Pro Cys Gln Ala Phe Asn His Tyr Leu 
        115                 120                 125             


Ser Ala Met Ala Ser Met Arg Gln Ala Glu Pro Ala Asp Met Arg Pro 
    130                 135                 140                 


Glu Ile Trp Ile Ala Gln Glu Leu Arg Arg Ile Gly Asp Glu Phe Asn 
145                 150                 155                 160 


Ala Tyr Tyr Ala Arg Arg Leu Glu Lys 
                165                 


<210> 4088
<211> 172
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 4088
Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Xaa Ser Leu Gln Xaa Glu Pro Gln Gly Asn Pro Glu Gly Asn His 
        35                  40                  45              


Gly Gly Glu Gly Asp Ser Cys Pro His Gly Ser Pro Gln Gly Pro Leu 
    50                  55                  60                  


Ala Pro Pro Ala Ser Pro Gly Pro Phe Ala Xaa Arg Ser Pro Leu Phe 
65                  70                  75                  80  


Ile Phe Met Arg Arg Ser Ser Leu Leu Ser Arg Ser Ser Ser Gly Tyr 
                85                  90                  95      


Phe Ser Phe Asp Xaa Asp Arg Ser Pro Ala Pro Met Ser Cys Asp Lys 
            100                 105                 110         


Ser Xaa Gln Xaa Pro Ser Pro Pro Cys Gln Ala Phe Asn His Tyr Leu 
        115                 120                 125             


Ser Ala Met Ala Ser Met Arg Gln Ala Glu Pro Ala Asp Met Arg Pro 
    130                 135                 140                 


Glu Ile Trp Ile Ala Gln Glu Leu Arg Arg Ile Gly Asp Glu Phe Asn 
145                 150                 155                 160 


Ala Tyr Tyr Ala Arg Arg Met Pro Leu Pro Pro Asp 
                165                 170         


<210> 4089
<211> 198
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 4089
Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Xaa Ser Leu Gln Xaa Glu Pro Gln Gly Asn Pro Glu Gly Asn His 
        35                  40                  45              


Gly Gly Glu Gly Asp Ser Cys Pro His Gly Ser Pro Gln Gly Pro Leu 
    50                  55                  60                  


Ala Pro Pro Ala Ser Pro Gly Pro Phe Ala Xaa Arg Ser Pro Leu Phe 
65                  70                  75                  80  


Ile Phe Met Arg Arg Ser Ser Leu Leu Ser Arg Ser Ser Ser Gly Tyr 
                85                  90                  95      


Phe Ser Phe Asp Xaa Asp Arg Ser Pro Ala Pro Met Ser Cys Asp Lys 
            100                 105                 110         


Ser Xaa Gln Xaa Pro Ser Pro Pro Cys Gln Ala Phe Asn His Tyr Leu 
        115                 120                 125             


Ser Ala Met Ala Ser Met Arg Gln Ala Glu Pro Ala Asp Met Arg Pro 
    130                 135                 140                 


Glu Ile Trp Ile Ala Gln Glu Leu Arg Arg Ile Gly Asp Glu Phe Asn 
145                 150                 155                 160 


Ala Tyr Tyr Ala Arg Arg Val Phe Leu Asn Asn Tyr Gln Ala Ala Glu 
                165                 170                 175     


Asp His Pro Arg Met Val Ile Leu Arg Leu Leu Arg Tyr Ile Val Arg 
            180                 185                 190         


Leu Val Trp Arg Met His 
        195             


<210> 4090
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 4090
Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Xaa Ser Leu Gln Xaa Glu Pro Gln Gly Asn Pro Glu Gly Asn His 
        35                  40                  45              


Gly Gly Glu Gly Asp Ser Cys Pro His Gly Ser Pro Gln Gly Pro Leu 
    50                  55                  60                  


Ala Pro Pro Ala Ser Pro Gly Pro Phe Ala Xaa Arg Ser Pro Leu Phe 
65                  70                  75                  80  


Ile Phe Met Arg Arg Ser Ser Leu Leu Ser Arg Ser Ser Ser Gly Tyr 
                85                  90                  95      


Phe Ser Phe Asp Xaa Asp Arg Ser Pro Ala Pro Met Ser Cys Asp Lys 
            100                 105                 110         


Ser Xaa Gln Xaa Pro Ser Pro Pro Cys Gln Ala Phe Asn His Tyr Leu 
        115                 120                 125             


Ser Ala Met Gly Ile Phe Glu 
    130                 135 


<210> 4091
<211> 140
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 4091
Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Xaa Ser Leu Gln Xaa Glu Pro Gln Gly Asn Pro Glu Gly Asn His 
        35                  40                  45              


Gly Gly Glu Gly Asp Ser Cys Pro His Gly Ser Pro Gln Gly Pro Leu 
    50                  55                  60                  


Ala Pro Pro Ala Ser Pro Gly Pro Phe Ala Xaa Arg Ser Pro Leu Phe 
65                  70                  75                  80  


Ile Phe Met Arg Arg Ser Ser Leu Leu Ser Arg Ser Ser Ser Gly Tyr 
                85                  90                  95      


Phe Ser Phe Asp Xaa Asp Arg Ser Pro Ala Pro Met Ser Cys Asp Lys 
            100                 105                 110         


Ser Xaa Gln Xaa Pro Ser Pro Pro Cys Gln Ala Phe Asn His Tyr Leu 
        115                 120                 125             


Ser Ala Met Val Arg Glu Ile Glu Glu Val Val Val 
    130                 135                 140 


<210> 4092
<211> 75
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<400> 4092
Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Xaa Ser Leu Gln Xaa Glu Pro Gln Val Ser Leu Cys His Pro Gly 
        35                  40                  45              


Trp Ser Ala Leu Val Arg Ser Trp Leu Xaa Ala Xaa Ser Asn Ser Gln 
    50                  55                  60                  


Val Gln Ala Val Leu Leu Pro Gln Pro Pro Lys 
65                  70                  75  


<210> 4093
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 4093
Met Ala Gly Ser Glu Glu Leu Gly Leu Arg Glu Asp Xaa Leu Arg Val 
1               5                   10                  15      


Leu Ala Ala Phe Leu Arg Arg Gly Glu Ala Ala Gly Ser Pro Val Pro 
            20                  25                  30          


Xaa Pro Pro Arg Pro Ser Tyr Ser Arg Leu Leu Cys Phe Gly Gly Pro 
        35                  40                  45              


Ala Ala Gly Xaa Ala Gly Pro Arg Ala Ala Glu Ile Ser Ala Gln Pro 
    50                  55                  60                  


Arg Ile Xaa Gly Ser Pro Ile Asp Arg Glu Gly Ser His Xaa Ala Glu 
65                  70                  75                  80  


Ala Gly Gly Pro Ala Gly Gly Gly Gly Arg Ser His 
                85                  90          


<210> 4094
<211> 250
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<400> 4094
Met Ala Gly Ser Glu Glu Leu Gly Leu Arg Glu Asp Xaa Leu Arg Val 
1               5                   10                  15      


Leu Ala Ala Phe Leu Arg Arg Gly Glu Ala Ala Gly Ser Pro Val Pro 
            20                  25                  30          


Xaa Pro Pro Arg Ser Pro Ala Gln Glu Glu Pro Xaa Asp Phe Leu Ser 
        35                  40                  45              


Arg Leu Arg Arg Cys Leu Pro Cys Ser Leu Gly Arg Gly Ala Ala Pro 
    50                  55                  60                  


Ser Glu Ser Pro Arg Pro Cys Ser Leu Pro Ile Arg Pro Cys Tyr Gly 
65                  70                  75                  80  


Leu Glu Pro Gly Pro Ala Xaa Pro Asp Phe Tyr Ala Leu Val Ala Gln 
                85                  90                  95      


Arg Leu Glu Gln Leu Val Gln Glu Gln Leu Lys Ser Pro Pro Ser Pro 
            100                 105                 110         


Glu Leu Gln Gly Pro Pro Ser Xaa Glu Lys Glu Ala Ile Leu Arg Arg 
        115                 120                 125             


Leu Val Ala Leu Leu Glu Glu Glu Ala Glu Val Ile Asn Gln Lys Leu 
    130                 135                 140                 


Ala Ser Asp Pro Ala Leu Arg Ser Lys Leu Val Arg Leu Ser Ser Asp 
145                 150                 155                 160 


Ser Phe Ala Arg Leu Val Glu Leu Phe Cys Ser Arg Asp Asp Ser Ser 
                165                 170                 175     


Arg Pro Ser Arg Ala Cys Pro Gly Pro Pro Pro Pro Ser Pro Glu Pro 
            180                 185                 190         


Leu Ala Arg Leu Ala Leu Ala Met Glu Leu Ser Arg Arg Val Ala Gly 
        195                 200                 205             


Leu Gly Gly Xaa Leu Ala Gly Leu Ser Val Glu His Val His Ser Phe 
    210                 215                 220                 


Xaa Pro Trp Ile Gln Ala His Gly Gly Trp Glu Gly Ile Leu Ala Val 
225                 230                 235                 240 


Ser Pro Val Asp Leu Asn Leu Pro Leu Asp 
                245                 250 


<210> 4095
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<400> 4095
Met Ala Gly Ser Glu Glu Leu Gly Leu Arg Glu Asp Xaa Leu Arg Val 
1               5                   10                  15      


Leu Ala Ala Phe Leu Arg Arg Gly Glu Ala Ala Gly Ser Pro Val Pro 
            20                  25                  30          


Xaa Pro Pro Arg Ser Pro Ala Gln Glu Glu Pro Xaa Asp Phe Leu Ser 
        35                  40                  45              


Arg Leu Arg Arg Cys Leu Pro Cys Ser Leu Gly Arg Gly Ala Ala Pro 
    50                  55                  60                  


Ser Glu Ser Pro Arg Pro Cys Ser Leu Pro Ile Arg Pro Cys Tyr Gly 
65                  70                  75                  80  


Leu Glu Pro Gly Pro Ala Xaa Pro Asp Phe Tyr Ala Leu Val Ala Gln 
                85                  90                  95      


Arg Leu Glu Gln Leu Val Gln Glu Gln Leu Lys Ser Pro Pro Ser Pro 
            100                 105                 110         


Gly Gly His Pro Gly Cys Phe Xaa Arg Gly Leu Glu Leu Ala Ile Gly 
        115                 120                 125             


Leu Ser Ser Phe Ser Glu Ala Ala Xaa Arg 
    130                 135             


<210> 4096
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<400> 4096
Met Ala Gly Ser Glu Glu Leu Gly Leu Arg Glu Asp Xaa Leu Arg Val 
1               5                   10                  15      


Leu Ala Ala Phe Leu Arg Arg Gly Glu Ala Ala Gly Ser Pro Val Pro 
            20                  25                  30          


Xaa Pro Pro Arg Ser Pro Ala Gln Glu Glu Pro Xaa Asp Phe Leu Ser 
        35                  40                  45              


Arg Leu Arg Arg Cys Leu Pro Cys Ser Leu Gly Val Glu His Val His 
    50                  55                  60                  


Ser Phe Xaa Pro Trp Ile Gln Ala His Gly Gly Trp Glu Gly Ile Leu 
65                  70                  75                  80  


Ala Val Ser Pro Val Asp Leu Asn Leu Pro Leu Asp 
                85                  90          


<210> 4097
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 4097
Met Gly Arg Pro Ala Gly Leu Phe Pro Pro Leu Cys Pro Phe Leu Gly 
1               5                   10                  15      


Phe Arg Pro Glu Ala Cys Trp Glu Arg His Met Gln Ile Glu Arg Ala 
            20                  25                  30          


Pro Ser Val Pro Pro Phe Leu Arg Trp Ala Gly Tyr Arg Pro Gly Pro 
        35                  40                  45              


Val Arg Arg Arg Gly Lys Val Glu Leu Ile Lys Phe Val Arg Val Gln 
    50                  55                  60                  


Trp Arg Arg Pro Gln Val Glu Trp Arg Arg Arg Arg Trp Gly Pro Gly 
65                  70                  75                  80  


Pro Gly Ala Ser Met Ala Gly Ser Glu Glu Leu Gly Leu Arg Glu Asp 
                85                  90                  95      


Xaa Leu Arg Val Leu Ala Ala Phe Leu Arg Arg Gly Glu Ala Ala Gly 
            100                 105                 110         


Ser Pro Val Pro Xaa Pro Pro Arg Arg Ala Ser Trp Leu Phe His Pro 
        115                 120                 125             


Trp Xaa 
    130 


<210> 4098
<211> 193
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<400> 4098
Met Gly Arg Pro Ala Gly Leu Phe Pro Pro Leu Cys Pro Phe Leu Gly 
1               5                   10                  15      


Phe Arg Pro Glu Ala Cys Trp Glu Arg His Met Gln Ile Glu Arg Ala 
            20                  25                  30          


Pro Ser Val Pro Pro Phe Leu Arg Trp Ala Gly Tyr Arg Pro Gly Pro 
        35                  40                  45              


Val Arg Arg Arg Gly Lys Val Glu Leu Ile Lys Phe Val Arg Val Gln 
    50                  55                  60                  


Trp Arg Arg Pro Gln Val Glu Trp Arg Arg Arg Arg Trp Gly Pro Gly 
65                  70                  75                  80  


Pro Gly Ala Ser Met Ala Gly Ser Glu Glu Leu Gly Leu Arg Glu Asp 
                85                  90                  95      


Xaa Leu Arg Val Leu Ala Ala Phe Leu Arg Arg Gly Glu Ala Ala Gly 
            100                 105                 110         


Ser Pro Val Pro Xaa Pro Pro Arg Ser Pro Ala Gln Glu Glu Pro Xaa 
        115                 120                 125             


Asp Phe Leu Ser Arg Leu Arg Arg Cys Leu Pro Cys Ser Leu Gly Arg 
    130                 135                 140                 


Gly Ala Ala Pro Ser Glu Ser Pro Arg Pro Cys Ser Leu Pro Ile Arg 
145                 150                 155                 160 


Pro Cys Tyr Gly Leu Glu Pro Gly Gly His Pro Gly Cys Phe Xaa Arg 
                165                 170                 175     


Gly Leu Glu Leu Ala Ile Gly Leu Ser Ser Phe Ser Glu Ala Ala Xaa 
            180                 185                 190         


Arg 
    


<210> 4099
<211> 334
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<400> 4099
Met Gly Arg Pro Ala Gly Leu Phe Pro Pro Leu Cys Pro Phe Leu Gly 
1               5                   10                  15      


Phe Arg Pro Glu Ala Cys Trp Glu Arg His Met Gln Ile Glu Arg Ala 
            20                  25                  30          


Pro Ser Val Pro Pro Phe Leu Arg Trp Ala Gly Tyr Arg Pro Gly Pro 
        35                  40                  45              


Val Arg Arg Arg Gly Lys Val Glu Leu Ile Lys Phe Val Arg Val Gln 
    50                  55                  60                  


Trp Arg Arg Pro Gln Val Glu Trp Arg Arg Arg Arg Trp Gly Pro Gly 
65                  70                  75                  80  


Pro Gly Ala Ser Met Ala Gly Ser Glu Glu Leu Gly Leu Arg Glu Asp 
                85                  90                  95      


Xaa Leu Arg Val Leu Ala Ala Phe Leu Arg Arg Gly Glu Ala Ala Gly 
            100                 105                 110         


Ser Pro Val Pro Xaa Pro Pro Arg Ser Pro Ala Gln Glu Glu Pro Xaa 
        115                 120                 125             


Asp Phe Leu Ser Arg Leu Arg Arg Cys Leu Pro Cys Ser Leu Gly Arg 
    130                 135                 140                 


Gly Ala Ala Pro Ser Glu Ser Pro Arg Pro Cys Ser Leu Pro Ile Arg 
145                 150                 155                 160 


Pro Cys Tyr Gly Leu Glu Pro Gly Pro Ala Xaa Pro Asp Phe Tyr Ala 
                165                 170                 175     


Leu Val Ala Gln Arg Leu Glu Gln Leu Val Gln Glu Gln Leu Lys Ser 
            180                 185                 190         


Pro Pro Ser Pro Glu Leu Gln Gly Pro Pro Ser Xaa Glu Lys Glu Ala 
        195                 200                 205             


Ile Leu Arg Arg Leu Val Ala Leu Leu Glu Glu Glu Ala Glu Val Ile 
    210                 215                 220                 


Asn Gln Lys Leu Ala Ser Asp Pro Ala Leu Arg Ser Lys Leu Val Arg 
225                 230                 235                 240 


Leu Ser Ser Asp Ser Phe Ala Arg Leu Val Glu Leu Phe Cys Ser Arg 
                245                 250                 255     


Asp Asp Ser Ser Arg Pro Ser Arg Ala Cys Pro Gly Pro Pro Pro Pro 
            260                 265                 270         


Ser Pro Glu Pro Leu Ala Arg Leu Ala Leu Ala Met Glu Leu Ser Arg 
        275                 280                 285             


Arg Val Ala Gly Leu Gly Gly Xaa Leu Ala Gly Leu Ser Val Glu His 
    290                 295                 300                 


Val His Ser Phe Xaa Pro Trp Ile Gln Ala His Gly Gly Trp Glu Gly 
305                 310                 315                 320 


Ile Leu Ala Val Ser Pro Val Asp Leu Asn Leu Pro Leu Asp 
                325                 330                 


<210> 4100
<211> 269
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<400> 4100
Met Gly Arg Pro Ala Gly Leu Phe Pro Pro Leu Cys Pro Phe Leu Gly 
1               5                   10                  15      


Phe Arg Pro Glu Ala Cys Trp Glu Arg His Met Gln Ile Glu Arg Ala 
            20                  25                  30          


Pro Ser Val Pro Pro Phe Leu Arg Trp Ala Gly Tyr Arg Pro Gly Pro 
        35                  40                  45              


Val Arg Arg Arg Gly Lys Val Glu Leu Ile Lys Phe Val Arg Val Gln 
    50                  55                  60                  


Trp Arg Arg Pro Gln Val Glu Trp Arg Arg Arg Arg Trp Gly Pro Gly 
65                  70                  75                  80  


Pro Gly Ala Ser Met Ala Gly Ser Glu Glu Leu Gly Leu Arg Glu Asp 
                85                  90                  95      


Xaa Leu Arg Val Leu Ala Ala Phe Leu Arg Arg Gly Glu Ala Ala Gly 
            100                 105                 110         


Ser Pro Val Pro Xaa Pro Pro Arg Ser Pro Ala Gln Glu Glu Pro Xaa 
        115                 120                 125             


Asp Phe Leu Ser Arg Leu Arg Arg Cys Leu Pro Cys Ser Leu Gly Arg 
    130                 135                 140                 


Gly Ala Ala Pro Ser Glu Ser Pro Arg Pro Cys Ser Leu Pro Ile Arg 
145                 150                 155                 160 


Pro Cys Tyr Gly Leu Glu Pro Gly Pro Ala Xaa Pro Asp Phe Tyr Ala 
                165                 170                 175     


Leu Val Ala Gln Arg Leu Glu Gln Leu Val Gln Glu Gln Leu Lys Ser 
            180                 185                 190         


Pro Pro Ser Pro Glu Leu Gln Gly Pro Pro Ser Xaa Glu Lys Glu Ala 
        195                 200                 205             


Ile Leu Arg Arg Leu Val Ala Leu Leu Glu Glu Glu Ala Glu Val Ile 
    210                 215                 220                 


Asn Gln Lys Val Met Gly Ile Cys Pro Xaa Pro Trp Gln Gly Gln Glu 
225                 230                 235                 240 


Leu Arg Asn Gly Gly His Pro Gly Cys Phe Xaa Arg Gly Leu Glu Leu 
                245                 250                 255     


Ala Ile Gly Leu Ser Ser Phe Ser Glu Ala Ala Xaa Arg 
            260                 265                 


<210> 4101
<211> 333
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<400> 4101
Met Gly Arg Pro Ala Gly Leu Phe Pro Pro Leu Cys Pro Phe Leu Gly 
1               5                   10                  15      


Phe Arg Pro Glu Ala Cys Trp Glu Arg His Met Gln Ile Glu Arg Ala 
            20                  25                  30          


Pro Ser Val Pro Pro Phe Leu Arg Trp Ala Gly Tyr Arg Pro Gly Pro 
        35                  40                  45              


Val Arg Arg Arg Gly Lys Val Glu Leu Ile Lys Phe Val Arg Val Gln 
    50                  55                  60                  


Trp Arg Arg Pro Gln Val Glu Trp Arg Arg Arg Arg Trp Gly Pro Gly 
65                  70                  75                  80  


Pro Gly Ala Ser Met Ala Gly Ser Glu Glu Leu Gly Leu Arg Glu Asp 
                85                  90                  95      


Xaa Leu Arg Val Leu Ala Ala Phe Leu Arg Arg Gly Glu Ala Ala Gly 
            100                 105                 110         


Ser Pro Val Pro Xaa Pro Pro Ser Pro Ala Gln Glu Glu Pro Xaa Asp 
        115                 120                 125             


Phe Leu Ser Arg Leu Arg Arg Cys Leu Pro Cys Ser Leu Gly Arg Gly 
    130                 135                 140                 


Ala Ala Pro Ser Glu Ser Pro Arg Pro Cys Ser Leu Pro Ile Arg Pro 
145                 150                 155                 160 


Cys Tyr Gly Leu Glu Pro Gly Pro Ala Xaa Pro Asp Phe Tyr Ala Leu 
                165                 170                 175     


Val Ala Gln Arg Leu Glu Gln Leu Val Gln Glu Gln Leu Lys Ser Pro 
            180                 185                 190         


Pro Ser Pro Glu Leu Gln Gly Pro Pro Ser Xaa Glu Lys Glu Ala Ile 
        195                 200                 205             


Leu Arg Arg Leu Val Ala Leu Leu Glu Glu Glu Ala Glu Val Ile Asn 
    210                 215                 220                 


Gln Lys Leu Ala Ser Asp Pro Ala Leu Arg Ser Lys Leu Val Arg Leu 
225                 230                 235                 240 


Ser Ser Asp Ser Phe Ala Arg Leu Val Glu Leu Phe Cys Ser Arg Asp 
                245                 250                 255     


Asp Ser Ser Arg Pro Ser Arg Ala Cys Pro Gly Pro Pro Pro Pro Ser 
            260                 265                 270         


Pro Glu Pro Leu Ala Arg Leu Ala Leu Ala Met Glu Leu Ser Arg Arg 
        275                 280                 285             


Val Ala Gly Leu Gly Gly Xaa Leu Ala Gly Leu Ser Val Glu His Val 
    290                 295                 300                 


His Ser Phe Xaa Pro Trp Ile Gln Ala His Gly Gly Trp Glu Gly Ile 
305                 310                 315                 320 


Leu Ala Val Ser Pro Val Asp Leu Asn Leu Pro Leu Asp 
                325                 330             


<210> 4102
<211> 51
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<400> 4102
Met Ala Xaa Pro Ala Ser Ala Pro Asp Xaa Arg Ala Leu Val Ala Asp 
1               5                   10                  15      


Phe Val Gly Tyr Lys Leu Arg Gln Lys Gly Tyr Val Cys Gly Ala Gly 
            20                  25                  30          


Pro Gly Glu Gly Pro Ala Ala Asp Pro Leu His Gln Ala Met Arg Ala 
        35                  40                  45              


Ala Gly Asp 
    50      


<210> 4103
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<400> 4103
Met Ala Xaa Pro Ala Ser Ala Pro Asp Xaa Arg Ala Leu Val Ala Asp 
1               5                   10                  15      


Phe Val Gly Tyr Lys Leu Arg Gln Lys Gly Tyr Val Cys Gly Ala Gly 
            20                  25                  30          


Pro Gly Glu Gly Pro Ala Ala Asp Pro Leu His Gln Ala Met Arg Ala 
        35                  40                  45              


Ala Gly Asp Glu Phe Glu Xaa Arg Phe Arg Arg Xaa Phe Ser Asp Leu 
    50                  55                  60                  


Ala Ala Gln Leu His Val Xaa Pro 
65                  70          


<210> 4104
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<400> 4104
Met Ala Xaa Pro Ala Ser Ala Pro Asp Xaa Arg Ala Leu Val Ala Asp 
1               5                   10                  15      


Phe Val Gly Tyr Lys Leu Arg Gln Lys Gly Tyr Val Cys Gly Ala Gly 
            20                  25                  30          


Pro Gly Glu Gly Pro Ala Ala Asp Pro Leu His Gln Ala Met Arg Ala 
        35                  40                  45              


Ala Gly Asp Glu Phe Glu Xaa Arg Phe Arg Arg Xaa Phe Ser Asp Leu 
    50                  55                  60                  


Ala Ala Gln Leu His Val Xaa Pro Gly Ser Ala Gln Gln Arg Phe Xaa 
65                  70                  75                  80  


Gln Val Ser Asp Glu Leu Phe Gln Gly Gly Pro Asn Trp Gly Arg Leu 
                85                  90                  95      


Val Ala Phe Phe Val Phe Gly Ala Ala Leu Cys Ala Glu Ser Val Asn 
            100                 105                 110         


Lys Glu Met Glu Pro Leu Val Gly Gln Val Gln Glu Trp Met Val Ala 
        115                 120                 125             


Tyr Leu Glu Xaa Gln Leu Ala Asp Trp Ile His Ser Ser Gly Gly Trp 
    130                 135                 140                 


<210> 4105
<211> 149
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 4105
Met Ala Xaa Pro Ala Ser Ala Pro Asp Xaa Arg Ala Leu Val Ala Asp 
1               5                   10                  15      


Phe Val Gly Tyr Lys Leu Arg Gln Lys Gly Tyr Val Cys Gly Ala Gly 
            20                  25                  30          


Pro Gly Glu Gly Pro Ala Ala Asp Pro Leu His Gln Ala Met Arg Ala 
        35                  40                  45              


Ala Gly Asp Glu Phe Glu Xaa Arg Phe Arg Arg Xaa Phe Ser Asp Leu 
    50                  55                  60                  


Ala Ala Gln Leu His Val Xaa Pro Gly Ser Ala Gln Gln Arg Phe Xaa 
65                  70                  75                  80  


Gln Val Ser Asp Glu Leu Phe Gln Gly Gly Pro Asn Trp Gly Arg Leu 
                85                  90                  95      


Val Ala Phe Phe Val Phe Gly Ala Ala Leu Cys Ala Glu Ser Val Asn 
            100                 105                 110         


Lys Glu Met Glu Pro Leu Val Gly Gln Val Gln Glu Trp Met Val Ala 
        115                 120                 125             


Tyr Leu Glu Xaa Gln Leu Ala Asp Trp Ile His Ser Ser Gly Gly Trp 
    130                 135                 140                 


Ala Glu Phe Xaa Ala 
145                 


<210> 4106
<211> 193
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<400> 4106
Met Ala Xaa Pro Ala Ser Ala Pro Asp Xaa Arg Ala Leu Val Ala Asp 
1               5                   10                  15      


Phe Val Gly Tyr Lys Leu Arg Gln Lys Gly Tyr Val Cys Gly Ala Gly 
            20                  25                  30          


Pro Gly Glu Gly Pro Ala Ala Asp Pro Leu His Gln Ala Met Arg Ala 
        35                  40                  45              


Ala Gly Asp Glu Phe Glu Xaa Arg Phe Arg Arg Xaa Phe Ser Asp Leu 
    50                  55                  60                  


Ala Ala Gln Leu His Val Xaa Pro Gly Ser Ala Gln Gln Arg Phe Xaa 
65                  70                  75                  80  


Gln Val Ser Asp Glu Leu Phe Gln Gly Gly Pro Asn Trp Gly Arg Leu 
                85                  90                  95      


Val Ala Phe Phe Val Phe Gly Ala Ala Leu Cys Ala Glu Ser Val Asn 
            100                 105                 110         


Lys Glu Met Glu Pro Leu Val Gly Gln Val Gln Glu Trp Met Val Ala 
        115                 120                 125             


Tyr Leu Glu Xaa Gln Leu Ala Asp Trp Ile His Ser Ser Gly Gly Trp 
    130                 135                 140                 


Ala Glu Phe Xaa Ala Leu Tyr Gly Asp Gly Ala Leu Glu Glu Ala Arg 
145                 150                 155                 160 


Arg Leu Arg Glu Gly Asn Trp Ala Ser Val Arg Xaa Val Leu Xaa Gly 
                165                 170                 175     


Ala Val Ala Leu Gly Ala Leu Val Xaa Val Gly Ala Phe Phe Ala Ser 
            180                 185                 190         


Lys 
    


<210> 4107
<211> 167
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<400> 4107
Xaa Arg Xaa Phe Ser Asp Leu Ala Ala Gln Leu His Val Xaa Pro Gly 
1               5                   10                  15      


Ser Ala Gln Gln Arg Phe Xaa Gln Val Ser Asp Glu Leu Phe Gln Gly 
            20                  25                  30          


Gly Pro Asn Trp Gly Arg Leu Val Ala Phe Phe Val Phe Gly Ala Ala 
        35                  40                  45              


Leu Cys Ala Glu Ser Val Asn Lys Glu Met Glu Pro Leu Val Gly Gln 
    50                  55                  60                  


Val Gln Glu Trp Met Val Ala Tyr Leu Glu Xaa Gln Leu Ala Asp Trp 
65                  70                  75                  80  


Ile His Ser Ser Gly Gly Trp Ala Glu Phe Xaa Ala Leu Tyr Gly Asp 
                85                  90                  95      


Gly Ala Leu Glu Glu Ala Arg Arg Leu Arg Glu Gly Asn Trp Ala Ser 
            100                 105                 110         


Val Arg Xaa Val Leu Xaa Gly Ala Val Ala Leu Gly Ala Leu Val Trp 
        115                 120                 125             


Ser Xaa Leu Phe Xaa Leu Pro Ser Xaa Xaa Gly His Ile Ser Leu Leu 
    130                 135                 140                 


Ala Phe Pro Gly Xaa Phe Ser Gln Glu Glu Leu Gln Gly Pro Trp Pro 
145                 150                 155                 160 


Gly Tyr Gln Asn Ala Leu Leu 
                165         


<210> 4108
<211> 333
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<400> 4108
Met Ala Xaa Pro Ala Ser Ala Pro Asp Xaa Arg Ala Leu Val Ala Asp 
1               5                   10                  15      


Phe Val Gly Tyr Lys Leu Arg Gln Lys Gly Tyr Val Cys Gly Ala Gly 
            20                  25                  30          


Pro Gly Glu Gly Pro Ala Ala Asp Pro Leu His Gln Ala Met Arg Ala 
        35                  40                  45              


Ala Gly Asp Glu Phe Glu Xaa Arg Phe Arg Arg Xaa Phe Ser Asp Leu 
    50                  55                  60                  


Ala Ala Gln Leu His Val Xaa Pro Gly Ser Ala Gln Gln Arg Phe Xaa 
65                  70                  75                  80  


Gln Val Ser Asp Glu Leu Phe Gln Gly Gly Pro Asn Trp Gly Arg Leu 
                85                  90                  95      


Val Ala Phe Phe Val Phe Gly Ala Ala Leu Cys Ala Glu Ser Val Asn 
            100                 105                 110         


Lys Glu Met Glu Pro Leu Val Gly Gln Val Gln Glu Trp Met Val Ala 
        115                 120                 125             


Tyr Leu Glu Xaa Gln Leu Ala Asp Trp Ile His Ser Ser Gly Gly Trp 
    130                 135                 140                 


Glu Leu Glu Ala Ile Lys Ala Arg Val Arg Glu Met Glu Glu Glu Ala 
145                 150                 155                 160 


Glu Lys Leu Lys Glu Leu Gln Asn Glu Val Glu Lys Gln Met Asn Met 
                165                 170                 175     


Ser Pro Pro Pro Gly Asn Ala Gly Pro Val Ile Met Ser Ile Glu Glu 
            180                 185                 190         


Lys Met Glu Ala Asp Ala Arg Ser Ile Tyr Val Gly Asn Val Asp Tyr 
        195                 200                 205             


Gly Ala Xaa Ala Glu Glu Leu Glu Ala His Phe His Gly Cys Gly Ser 
    210                 215                 220                 


Val Asn Arg Val Xaa Ile Leu Cys Asp Lys Phe Ser Gly His Pro Lys 
225                 230                 235                 240 


Gly Phe Ala Tyr Ile Glu Phe Ser Asp Lys Glu Ser Val Arg Xaa Ser 
                245                 250                 255     


Leu Ala Leu Asp Glu Ser Leu Phe Arg Gly Arg Gln Ile Lys Val Ile 
            260                 265                 270         


Pro Lys Arg Xaa Asn Arg Pro Gly Ile Ser Xaa Xaa Asp Arg Gly Phe 
        275                 280                 285             


Pro Arg Ala Arg Tyr Arg Ala Arg Xaa Xaa Asn Tyr Asn Ser Ser Arg 
    290                 295                 300                 


Ser Arg Phe Tyr Ser Gly Phe Asn Ser Arg Pro Arg Gly Arg Val Tyr 
305                 310                 315                 320 


Arg Gly Arg Ala Arg Ala Xaa Ser Trp Tyr Ser Pro Tyr 
                325                 330             


<210> 4109
<211> 454
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<400> 4109
Met Pro Arg Cys Pro Ala Gly Ala Met Asp Glu Gly Pro Val Asp Leu 
1               5                   10                  15      


Arg Xaa Arg Pro Lys Ala Ala Gly Leu Pro Gly Ala Ala Leu Pro Leu 
            20                  25                  30          


Arg Lys Arg Pro Leu Arg Ala Pro Ser Pro Glu Pro Ala Ala Pro Arg 
        35                  40                  45              


Gly Ala Ala Gly Leu Val Val Pro Leu Asp Pro Leu Arg Gly Gly Cys 
    50                  55                  60                  


Asp Leu Pro Ala Val Pro Gly Pro Pro His Gly Leu Ala Arg Pro Glu 
65                  70                  75                  80  


Ala Leu Tyr Tyr Pro Gly Ala Leu Leu Pro Leu Tyr Pro Xaa Arg Ala 
                85                  90                  95      


Met Gly Ser Pro Phe Pro Leu Val Asn Leu Pro Xaa Pro Leu Tyr Pro 
            100                 105                 110         


Met Met Cys Pro Met Glu His Pro Leu Ser Ala Asp Ile Ala Met Ala 
        115                 120                 125             


Xaa Arg Ala Asp Glu Asp Gly Asp Xaa Pro Leu His Ile Ala Val Val 
    130                 135                 140                 


Gln Gly Asn Leu Pro Ala Val His Arg Leu Val Asn Leu Phe Gln Gln 
145                 150                 155                 160 


Gly Gly Arg Glu Leu Asp Ile Tyr Asn Asn Leu Arg Gln Xaa Pro Leu 
                165                 170                 175     


His Leu Ala Val Ile Xaa Xaa Leu Pro Ser Val Val Arg Leu Leu Val 
            180                 185                 190         


Xaa Ala Gly Ala Ser Pro Met Ala Leu Asp Arg His Gly Gln Xaa Ala 
        195                 200                 205             


Ala His Leu Ala Cys Glu His Arg Ser Pro Xaa Cys Leu Arg Ala Leu 
    210                 215                 220                 


Leu Asp Ser Ala Ala Pro Gly Xaa Leu Asp Leu Glu Ala Arg Asn Tyr 
225                 230                 235                 240 


Asp Gly Leu Xaa Ala Leu His Val Ala Val Asn Xaa Glu Cys Gln Glu 
                245                 250                 255     


Xaa Val Gln Leu Leu Leu Glu Arg Gly Ala Asp Ile Asp Ala Val Asp 
            260                 265                 270         


Ile Lys Ser Gly Arg Ser Pro Leu Ile His Ala Val Glu Asn Asn Ser 
        275                 280                 285             


Leu Ser Met Val Gln Leu Leu Leu Gln His Gly Ala Asn Val Asn Ala 
    290                 295                 300                 


Gln Met Tyr Ser Gly Ser Ser Ala Leu His Ser Ala Ser Gly Arg Gly 
305                 310                 315                 320 


Leu Leu Pro Leu Val Arg Xaa Leu Val Arg Ser Gly Ala Asp Ser Ser 
                325                 330                 335     


Leu Lys Asn Cys His Asn Asp Xaa Pro Leu Met Val Ala Arg Ser Arg 
            340                 345                 350         


Arg Val Ile Asp Ile Leu Arg Gly Lys Ala Xaa Arg Pro Ala Ser Xaa 
        355                 360                 365             


Ser Gln Pro Asp Pro Ser Pro Asp Arg Ser Ala Asn Xaa Ser Pro Glu 
    370                 375                 380                 


Ser Ser Ser Arg Leu Ser Ser Asn Gly Leu Leu Ser Ala Ser Pro Ser 
385                 390                 395                 400 


Ser Ser Pro Ser Gln Ser Pro Pro Arg Asp Pro Pro Gly Phe Pro Met 
                405                 410                 415     


Ala Pro Pro Asn Phe Phe Leu Pro Ser Pro Ser Pro Pro Ala Phe Leu 
            420                 425                 430         


Pro Phe Ala Gly Val Leu Arg Gly Pro Gly Arg Pro Val Pro Pro Ser 
        435                 440                 445             


Pro Ala Pro Gly Gly Ser 
    450                 


<210> 4110
<211> 308
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<400> 4110
Xaa Glu His Pro Leu Ser Ala Asp Ile Ala Met Ala Xaa Arg Ala Asp 
1               5                   10                  15      


Glu Asp Gly Asp Xaa Pro Leu His Ile Ala Val Val Gln Gly Asn Leu 
            20                  25                  30          


Pro Ala Val His Arg Leu Val Asn Leu Phe Gln Gln Gly Gly Arg Glu 
        35                  40                  45              


Leu Asp Ile Tyr Asn Asn Leu Arg Gln Xaa Pro Leu His Leu Ala Val 
    50                  55                  60                  


Ile Xaa Xaa Leu Pro Ser Val Val Arg Leu Leu Val Xaa Ala Gly Ala 
65                  70                  75                  80  


Ser Pro Met Ala Leu Asp Arg His Gly Gln Xaa Ala Ala His Leu Ala 
                85                  90                  95      


Cys Glu His Arg Ser Pro Xaa Cys Leu Arg Ala Leu Leu Asp Ser Ala 
            100                 105                 110         


Ala Pro Gly Xaa Leu Asp Leu Glu Ala Arg Asn Tyr Asp Gly Leu Xaa 
        115                 120                 125             


Ala Leu His Val Ala Val Asn Xaa Glu Cys Gln Glu Xaa Val Gln Leu 
    130                 135                 140                 


Leu Leu Glu Arg Gly Ala Asp Ile Asp Ala Val Asp Ile Lys Ser Gly 
145                 150                 155                 160 


Arg Ser Pro Leu Ile His Ala Val Glu Asn Asn Ser Leu Ser Met Val 
                165                 170                 175     


Gln Leu Leu Leu Gln His Gly Ala Asn Val Asn Ala Gln Met Tyr Ser 
            180                 185                 190         


Gly Ser Ser Ala Leu His Ser Ala Ser Gly Arg Gly Leu Leu Pro Leu 
        195                 200                 205             


Val Arg Xaa Leu Val Arg Ser Gly Ala Asp Ser Ser Leu Lys Asn Cys 
    210                 215                 220                 


His Asn Asp Xaa Pro Leu Met Val Ala Arg Ser Arg Arg Val Ser Arg 
225                 230                 235                 240 


Gly Ser Cys Gly His Ala Pro Cys Xaa Arg Val Ser Ala Gly Trp Leu 
                245                 250                 255     


Gln Val Ile Asp Ile Leu Arg Gly Lys Ala Xaa Arg Pro Ala Ser Xaa 
            260                 265                 270         


Ser Gln Pro Asp Pro Ser Pro Asp Arg Ser Ala Asn Xaa Ser Pro Glu 
        275                 280                 285             


Ser Ser Ser Arg Leu Ser Ser Asn Gly Leu Leu Ser Ala Ser Pro Ser 
    290                 295                 300                 


Ser Ser Pro Ser 
305             


<210> 4111
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<400> 4111
Met Ala Ser Pro Ala Asp Ser Cys Ile Gln Phe Xaa Arg His Ala Ser 
1               5                   10                  15      


Asp Val Leu Leu Asn Leu Asn Arg Leu Arg Ser Arg Asp Ile Leu Xaa 
            20                  25                  30          


Asp Val Val Ile Val Val Ser Arg Glu Gln Phe Arg Ala His Lys Xaa 
        35                  40                  45              


Val Leu Met Ala Cys Arg Ser 
    50                  55  


<210> 4112
<211> 104
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 4112
Met Ala Ser Pro Ala Asp Ser Cys Ile Gln Phe Xaa Arg His Ala Ser 
1               5                   10                  15      


Asp Val Leu Leu Asn Leu Asn Arg Leu Arg Ser Arg Asp Ile Leu Xaa 
            20                  25                  30          


Asp Val Val Ile Val Val Ser Arg Glu Gln Phe Arg Ala His Lys Xaa 
        35                  40                  45              


Val Leu Met Ala Cys Ser Gly Leu Phe Tyr Ser Ile Phe Xaa Asp Gln 
    50                  55                  60                  


Leu Lys Cys Asn Leu Ser Val Ile Asn Leu Asp Pro Glu Ile Asn Pro 
65                  70                  75                  80  


Glu Gly Phe Cys Ile Leu Leu Asp Phe Met Tyr Xaa Ser Arg Leu Asn 
                85                  90                  95      


Leu Arg Glu Gly Asn Ile Met Ala 
            100                 


<210> 4113
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<400> 4113
Met Ala Ser Pro Ala Asp Ser Cys Ile Gln Phe Xaa Arg His Ala Ser 
1               5                   10                  15      


Asp Val Leu Leu Asn Leu Asn Arg Leu Arg Ser Arg Asp Ile Leu Xaa 
            20                  25                  30          


Asp Val Val Ile Val Val Ser Arg Glu Gln Phe Arg Ala His Lys Xaa 
        35                  40                  45              


Val Leu Met Ala Cys Ser Gly Leu Phe Tyr Ser Ile Phe Xaa Asp Gln 
    50                  55                  60                  


Leu Lys Cys Asn Leu Ser Val Ile Asn Leu Asp Pro Glu Ile Asn Pro 
65                  70                  75                  80  


Glu Gly Phe Cys Ile Leu Leu Asp Phe Met Tyr Xaa Ser Arg Leu Asn 
                85                  90                  95      


Leu Arg Glu Gly Asn Ile Met Ala Val Met Ala Xaa Ala Met Tyr Leu 
            100                 105                 110         


Gln Met Glu His Val Val Asp Xaa Cys Arg 
        115                 120         


<210> 4114
<211> 650
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<400> 4114
Met Ala Ser Pro Ala Asp Ser Cys Ile Gln Phe Xaa Arg His Ala Ser 
1               5                   10                  15      


Asp Val Leu Leu Asn Leu Asn Arg Leu Arg Ser Arg Asp Ile Leu Xaa 
            20                  25                  30          


Asp Val Val Ile Val Val Ser Arg Glu Gln Phe Arg Ala His Lys Xaa 
        35                  40                  45              


Val Leu Met Ala Cys Ser Gly Leu Phe Tyr Ser Ile Phe Xaa Asp Gln 
    50                  55                  60                  


Leu Lys Cys Asn Leu Ser Val Ile Asn Leu Asp Pro Glu Ile Asn Pro 
65                  70                  75                  80  


Glu Gly Phe Cys Ile Leu Leu Asp Phe Met Tyr Xaa Ser Arg Leu Asn 
                85                  90                  95      


Leu Arg Glu Gly Asn Ile Met Ala Val Met Ala Xaa Ala Met Tyr Leu 
            100                 105                 110         


Gln Met Glu His Val Val Asp Xaa Cys Arg Lys Phe Ile Lys Ala Ser 
        115                 120                 125             


Glu Ala Glu Met Val Ser Ala Ile Lys Pro Pro Arg Glu Glu Phe Leu 
    130                 135                 140                 


Asn Ser Arg Met Leu Met Pro Gln Asp Ile Met Ala Tyr Arg Gly Arg 
145                 150                 155                 160 


Glu Val Val Glu Asn Asn Leu Pro Leu Arg Ser Ala Pro Gly Cys Glu 
                165                 170                 175     


Ser Arg Ala Phe Ala Pro Ser Leu Tyr Ser Gly Leu Ser Xaa Pro Pro 
            180                 185                 190         


Ala Ser Tyr Ser Met Tyr Ser His Leu Pro Val Ser Ser Leu Leu Phe 
        195                 200                 205             


Ser Asp Glu Glu Phe Arg Asp Val Arg Met Pro Val Ala Asn Pro Phe 
    210                 215                 220                 


Pro Lys Glu Arg Ala Leu Pro Cys Asp Ser Ala Arg Pro Val Pro Gly 
225                 230                 235                 240 


Glu Tyr Ser Arg Pro Xaa Leu Glu Val Ser Pro Asn Val Cys His Ser 
                245                 250                 255     


Asn Ile Tyr Ser Pro Lys Glu Xaa Ile Pro Glu Glu Ala Arg Ser Asp 
            260                 265                 270         


Met His Tyr Ser Val Ala Glu Gly Leu Lys Pro Ala Ala Pro Ser Ala 
        275                 280                 285             


Arg Asn Ala Pro Tyr Phe Pro Cys Asp Lys Ala Ser Lys Glu Glu Glu 
    290                 295                 300                 


Arg Pro Ser Ser Glu Asp Glu Ile Ala Leu His Phe Glu Pro Pro Asn 
305                 310                 315                 320 


Ala Pro Leu Asn Arg Lys Gly Leu Val Ser Pro Gln Ser Pro Gln Lys 
                325                 330                 335     


Ser Asp Cys Gln Pro Asn Ser Pro Xaa Glu Ser Cys Ser Ser Lys Asn 
            340                 345                 350         


Ala Cys Ile Leu Gln Ala Ser Gly Ser Pro Pro Ala Lys Ser Pro Xaa 
        355                 360                 365             


Asp Pro Lys Ala Cys Asn Trp Lys Lys Tyr Lys Phe Ile Val Leu Asn 
    370                 375                 380                 


Ser Leu Asn Gln Asn Ala Lys Pro Glu Gly Pro Glu Gln Ala Glu Leu 
385                 390                 395                 400 


Gly Arg Leu Ser Pro Arg Ala Tyr Xaa Ala Pro Pro Ala Cys Gln Pro 
                405                 410                 415     


Pro Met Glu Pro Glu Asn Leu Asp Leu Gln Ser Pro Xaa Lys Leu Ser 
            420                 425                 430         


Ala Ser Gly Glu Asp Ser Xaa Ile Pro Gln Ala Ser Arg Leu Asn Asn 
        435                 440                 445             


Ile Val Asn Arg Ser Met Xaa Gly Ser Pro Arg Ser Ser Ser Glu Ser 
    450                 455                 460                 


His Ser Pro Leu Tyr Met His Pro Pro Lys Cys Xaa Ser Cys Gly Ser 
465                 470                 475                 480 


Gln Ser Pro Gln His Ala Glu Met Cys Leu His Xaa Ala Gly Pro Xaa 
                485                 490                 495     


Phe Pro Glu Glu Met Gly Glu Xaa Gln Ser Glu Tyr Ser Asp Ser Ser 
            500                 505                 510         


Cys Gly Glu Lys Pro Tyr Arg Cys Asn Ile Cys Gly Ala Gln Phe Asn 
        515                 520                 525             


Arg Pro Ala Asn Leu Lys Xaa His Xaa Arg Ile His Ser Gly Glu Lys 
    530                 535                 540                 


Pro Tyr Lys Cys Glu Xaa Cys Gly Ala Arg Phe Val Gln Val Ala His 
545                 550                 555                 560 


Leu Arg Ala His Val Leu Ile His Xaa Gly Glu Lys Pro Tyr Pro Cys 
                565                 570                 575     


Glu Ile Cys Gly Xaa Arg Phe Arg His Leu Gln Xaa Leu Lys Ser His 
            580                 585                 590         


Leu Arg Ile His Xaa Gly Glu Lys Pro Tyr His Cys Glu Lys Cys Asn 
        595                 600                 605             


Leu His Phe Arg His Lys Ser Gln Leu Arg Leu His Leu Arg Gln Lys 
    610                 615                 620                 


His Gly Ala Ile Xaa Asn Xaa Lys Val Gln Tyr Arg Val Ser Ala Xaa 
625                 630                 635                 640 


Asp Leu Pro Pro Glu Leu Pro Lys Ala Cys 
                645                 650 


<210> 4115
<211> 706
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<400> 4115
Met Ala Ser Pro Ala Asp Ser Cys Ile Gln Phe Xaa Arg His Ala Ser 
1               5                   10                  15      


Asp Val Leu Leu Asn Leu Asn Arg Leu Arg Ser Arg Asp Ile Leu Xaa 
            20                  25                  30          


Asp Val Val Ile Val Val Ser Arg Glu Gln Phe Arg Ala His Lys Xaa 
        35                  40                  45              


Val Leu Met Ala Cys Ser Gly Leu Phe Tyr Ser Ile Phe Xaa Asp Gln 
    50                  55                  60                  


Leu Lys Cys Asn Leu Ser Val Ile Asn Leu Asp Pro Glu Ile Asn Pro 
65                  70                  75                  80  


Glu Gly Phe Cys Ile Leu Leu Asp Phe Met Tyr Xaa Ser Arg Leu Asn 
                85                  90                  95      


Leu Arg Glu Gly Asn Ile Met Ala Val Met Ala Xaa Ala Met Tyr Leu 
            100                 105                 110         


Gln Met Glu His Val Val Asp Xaa Cys Arg Lys Phe Ile Lys Ala Ser 
        115                 120                 125             


Glu Ala Glu Met Val Ser Ala Ile Lys Pro Pro Arg Glu Glu Phe Leu 
    130                 135                 140                 


Asn Ser Arg Met Leu Met Pro Gln Asp Ile Met Ala Tyr Arg Gly Arg 
145                 150                 155                 160 


Glu Val Val Glu Asn Asn Leu Pro Leu Arg Ser Ala Pro Gly Cys Glu 
                165                 170                 175     


Ser Arg Ala Phe Ala Pro Ser Leu Tyr Ser Gly Leu Ser Xaa Pro Pro 
            180                 185                 190         


Ala Ser Tyr Ser Met Tyr Ser His Leu Pro Val Ser Ser Leu Leu Phe 
        195                 200                 205             


Ser Asp Glu Glu Phe Arg Asp Val Arg Met Pro Val Ala Asn Pro Phe 
    210                 215                 220                 


Pro Lys Glu Arg Ala Leu Pro Cys Asp Ser Ala Arg Pro Val Pro Gly 
225                 230                 235                 240 


Glu Tyr Ser Arg Pro Xaa Leu Glu Val Ser Pro Asn Val Cys His Ser 
                245                 250                 255     


Asn Ile Tyr Ser Pro Lys Glu Xaa Ile Pro Glu Glu Ala Arg Ser Asp 
            260                 265                 270         


Met His Tyr Ser Val Ala Glu Gly Leu Lys Pro Ala Ala Pro Ser Ala 
        275                 280                 285             


Arg Asn Ala Pro Tyr Phe Pro Cys Asp Lys Ala Ser Lys Glu Glu Glu 
    290                 295                 300                 


Arg Pro Ser Ser Glu Asp Glu Ile Ala Leu His Phe Glu Pro Pro Asn 
305                 310                 315                 320 


Ala Pro Leu Asn Arg Lys Gly Leu Val Ser Pro Gln Ser Pro Gln Lys 
                325                 330                 335     


Ser Asp Cys Gln Pro Asn Ser Pro Xaa Glu Ser Cys Ser Ser Lys Asn 
            340                 345                 350         


Ala Cys Ile Leu Gln Ala Ser Gly Ser Pro Pro Ala Lys Ser Pro Xaa 
        355                 360                 365             


Asp Pro Lys Ala Cys Asn Trp Lys Lys Tyr Lys Phe Ile Val Leu Asn 
    370                 375                 380                 


Ser Leu Asn Gln Asn Ala Lys Pro Glu Gly Pro Glu Gln Ala Glu Leu 
385                 390                 395                 400 


Gly Arg Leu Ser Pro Arg Ala Tyr Xaa Ala Pro Pro Ala Cys Gln Pro 
                405                 410                 415     


Pro Met Glu Pro Glu Asn Leu Asp Leu Gln Ser Pro Xaa Lys Leu Ser 
            420                 425                 430         


Ala Ser Gly Glu Asp Ser Xaa Ile Pro Gln Ala Ser Arg Leu Asn Asn 
        435                 440                 445             


Ile Val Asn Arg Ser Met Xaa Gly Ser Pro Arg Ser Ser Ser Glu Ser 
    450                 455                 460                 


His Ser Pro Leu Tyr Met His Pro Pro Lys Cys Xaa Ser Cys Gly Ser 
465                 470                 475                 480 


Gln Ser Pro Gln His Ala Glu Met Cys Leu His Xaa Ala Gly Pro Xaa 
                485                 490                 495     


Phe Pro Glu Glu Met Gly Glu Xaa Gln Ser Glu Tyr Ser Asp Ser Ser 
            500                 505                 510         


Cys Glu Asn Gly Ala Phe Phe Cys Asn Glu Cys Asp Cys Arg Phe Ser 
        515                 520                 525             


Glu Glu Ala Ser Leu Lys Arg His Xaa Leu Gln Xaa His Ser Asp Lys 
    530                 535                 540                 


Pro Tyr Lys Cys Asp Arg Cys Gln Ala Ser Phe Arg Tyr Lys Gly Asn 
545                 550                 555                 560 


Leu Ala Ser His Lys Xaa Val His Xaa Gly Glu Lys Pro Tyr Arg Cys 
                565                 570                 575     


Asn Ile Cys Gly Ala Gln Phe Asn Arg Pro Ala Asn Leu Lys Xaa His 
            580                 585                 590         


Xaa Arg Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Glu Xaa Cys Gly 
        595                 600                 605             


Ala Arg Phe Val Gln Val Ala His Leu Arg Ala His Val Leu Ile His 
    610                 615                 620                 


Xaa Gly Glu Lys Pro Tyr Pro Cys Glu Ile Cys Gly Xaa Arg Phe Arg 
625                 630                 635                 640 


His Leu Gln Xaa Leu Lys Ser His Leu Arg Ile His Xaa Gly Glu Lys 
                645                 650                 655     


Pro Tyr His Cys Glu Lys Cys Asn Leu His Phe Arg His Lys Ser Gln 
            660                 665                 670         


Leu Arg Leu His Leu Arg Gln Lys His Gly Ala Ile Xaa Asn Xaa Lys 
        675                 680                 685             


Val Gln Tyr Arg Val Ser Ala Xaa Asp Leu Pro Pro Glu Leu Pro Lys 
    690                 695                 700                 


Ala Cys 
705     


<210> 4116
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<400> 4116
Cys Ser Ser Gly Leu Asp Ser Leu Val Pro Gly Asp Glu Asp Lys Pro 
1               5                   10                  15      


Tyr Lys Cys Gln Leu Cys Arg Ser Ser Phe Arg Tyr Lys Gly Asn Leu 
            20                  25                  30          


Ala Ser His Arg Xaa Val His Xaa Gly Glu Lys Pro Tyr His Cys Ser 
        35                  40                  45              


Ile Cys Gly Ala Arg Phe Asn Arg Pro Ala Asn Leu Lys Xaa His Ser 
    50                  55                  60                  


Arg Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Glu Xaa Cys Gly Ser 
65                  70                  75                  80  


Arg Phe Val Gln Val Ala His Leu Arg Ala His Val Leu Ile His Xaa 
                85                  90                  95      


Gly Glu Lys Pro Tyr Pro Cys Pro Xaa Cys Gly Xaa Arg Phe Arg His 
            100                 105                 110         


Leu Gln Xaa Leu Lys Ser His Val Arg Ile His Xaa Gly Glu Lys Pro 
        115                 120                 125             


Tyr His Glu Pro Val Xaa Ser 
    130                 135 


<210> 4117
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<400> 4117
Met Gly Ser Pro Ala Ala Pro Glu Gly Ala Leu Gly Tyr Val Arg Glu 
1               5                   10                  15      


Phe Xaa Arg His Ser Ser Asp Val Leu Gly Asn Leu Asn Glu Leu Arg 
            20                  25                  30          


Leu Arg Gly Ile Leu Xaa Asp Val Xaa Leu Leu Val Gly Gly Gln Pro 
        35                  40                  45              


Leu Arg Ala His Lys Ala Val Leu Ile Ala Cys Ser Gly Phe Phe Tyr 
    50                  55                  60                  


Ser Ile Phe Arg Gly Arg Ala Gly Val Gly Val Asp Val Leu Ser Leu 
65                  70                  75                  80  


Pro Gly Gly Pro Glu Ala Arg Gly Phe Ala Pro Leu Leu Asp Phe Met 
                85                  90                  95      


Tyr Xaa Ser Arg Leu Arg Leu Ser Pro Ala Xaa Ala Pro Ala Val 
            100                 105                 110     


<210> 4118
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 4118
Met Gly Ser Pro Ala Ala Pro Glu Gly Ala Leu Gly Tyr Val Arg Glu 
1               5                   10                  15      


Phe Xaa Arg His Ser Ser Asp Val Leu Gly Asn Leu Asn Glu Leu Arg 
            20                  25                  30          


Leu Arg Gly Ile Leu Xaa Asp Val Xaa Leu Leu Val Gly Gly Gln Pro 
        35                  40                  45              


Leu Arg Ala His Lys Ala Val Leu Ile Ala Cys Ser Gly Phe Phe Tyr 
    50                  55                  60                  


Ser Ile Phe Arg Gly Arg Ala Gly Val Gly Val Asp Val Leu Ser Leu 
65                  70                  75                  80  


Pro Gly Gly Pro Glu Ala Arg Gly Phe Ala Pro Leu Leu Asp Phe Met 
                85                  90                  95      


Tyr Xaa Ser Arg Leu Arg Leu Ser Pro Ala Xaa Ala Pro Ala Val Leu 
            100                 105                 110         


Ala Ala Ala Xaa Tyr Leu Gln Met Glu His Val Val Gln Ala Cys His 
        115                 120                 125             


Arg Phe Ile Gln Ala 
    130             


<210> 4119
<211> 479
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<400> 4119
Met Gly Ser Pro Ala Ala Pro Glu Gly Ala Leu Gly Tyr Val Arg Glu 
1               5                   10                  15      


Phe Xaa Arg His Ser Ser Asp Val Leu Gly Asn Leu Asn Glu Leu Arg 
            20                  25                  30          


Leu Arg Gly Ile Leu Xaa Asp Val Xaa Leu Leu Val Gly Gly Gln Pro 
        35                  40                  45              


Leu Arg Ala His Lys Ala Val Leu Ile Ala Cys Ser Gly Phe Phe Tyr 
    50                  55                  60                  


Ser Ile Phe Arg Gly Arg Ala Gly Val Gly Val Asp Val Leu Ser Leu 
65                  70                  75                  80  


Pro Gly Gly Pro Glu Ala Arg Gly Phe Ala Pro Leu Leu Asp Phe Met 
                85                  90                  95      


Tyr Xaa Ser Arg Leu Arg Leu Ser Pro Ala Xaa Ala Pro Ala Val Leu 
            100                 105                 110         


Ala Ala Ala Xaa Tyr Leu Gln Met Glu His Val Val Gln Ala Cys His 
        115                 120                 125             


Arg Phe Ile Gln Ala Ser Tyr Glu Pro Leu Gly Ile Ser Leu Arg Pro 
    130                 135                 140                 


Leu Glu Ala Glu Pro Pro Xaa Pro Pro Xaa Ala Pro Pro Pro Gly Ser 
145                 150                 155                 160 


Pro Arg Arg Ser Glu Gly His Pro Asp Pro Pro Xaa Glu Ser Arg Ser 
                165                 170                 175     


Cys Ser Gln Gly Pro Pro Ser Pro Ala Ser Pro Asp Pro Lys Ala Cys 
            180                 185                 190         


Asn Trp Lys Lys Tyr Lys Tyr Ile Val Leu Asn Ser Gln Ala Ser Gln 
        195                 200                 205             


Ala Gly Ser Leu Val Gly Glu Arg Ser Ser Gly Gln Pro Cys Pro Gln 
    210                 215                 220                 


Ala Arg Leu Pro Ser Gly Asp Glu Ala Ser Ser Ser Ser Ser Ser Ser 
225                 230                 235                 240 


Ser Ser Ser Ser Glu Glu Gly Pro Ile Pro Gly Pro Gln Ser Arg Leu 
                245                 250                 255     


Ser Pro Xaa Ala Ala Xaa Val Gln Phe Lys Cys Gly Ala Pro Ala Ser 
            260                 265                 270         


Xaa Pro Tyr Leu Leu Xaa Ser Gln Ala Gln Asp Xaa Ser Gly Ser Pro 
        275                 280                 285             


Ser Glu Arg Ala Arg Pro Leu Pro Gly Ser Glu Phe Phe Ser Cys Gln 
    290                 295                 300                 


Asn Cys Glu Ala Val Ala Gly Cys Ser Ser Gly Leu Asp Ser Leu Val 
305                 310                 315                 320 


Pro Gly Asp Glu Asp Lys Pro Tyr Lys Cys Gln Leu Cys Arg Ser Ser 
                325                 330                 335     


Phe Arg Tyr Lys Gly Asn Leu Ala Ser His Arg Xaa Val His Xaa Gly 
            340                 345                 350         


Glu Lys Pro Tyr His Cys Ser Ile Cys Gly Ala Arg Phe Asn Arg Pro 
        355                 360                 365             


Ala Asn Leu Lys Xaa His Ser Arg Ile His Ser Gly Glu Lys Pro Tyr 
    370                 375                 380                 


Lys Cys Glu Xaa Cys Gly Ser Arg Phe Val Gln Val Ala His Leu Arg 
385                 390                 395                 400 


Ala His Val Leu Ile His Xaa Gly Glu Lys Pro Tyr Pro Cys Pro Xaa 
                405                 410                 415     


Cys Gly Xaa Arg Phe Arg His Leu Gln Xaa Leu Lys Ser His Val Arg 
            420                 425                 430         


Ile His Xaa Gly Glu Lys Pro Tyr His Cys Asp Pro Cys Gly Leu His 
        435                 440                 445             


Phe Arg His Lys Ser Gln Leu Arg Leu His Leu Arg Gln Lys His Gly 
    450                 455                 460                 


Ala Ala Xaa Asn Xaa Lys Val His Tyr His Ile Leu Gly Gly Pro 
465                 470                 475                 


<210> 4120
<211> 202
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<400> 4120
Met Ser Gly Arg Ser Val Arg Ala Glu Xaa Arg Ser Arg Ala Lys Asp 
1               5                   10                  15      


Asp Ile Lys Lys Val Met Ala Ala Ile Glu Lys Val Arg Lys Trp Glu 
            20                  25                  30          


Lys Lys Trp Val Xaa Val Gly Asp Xaa Ser Leu Arg Ile Phe Lys Trp 
        35                  40                  45              


Val Pro Val Xaa Asp Ser Lys Glu Lys Glu Lys Ser Lys Ser Asn Ser 
    50                  55                  60                  


Ser Ala Ala Arg Glu Pro Asn Gly Phe Pro Ser Asp Ala Ser Ala Asn 
65                  70                  75                  80  


Ser Ser Leu Leu Leu Glu Phe Gln Asp Glu Asn Ser Asn Gln Ser Ser 
                85                  90                  95      


Val Ser Asp Val Tyr Gln Leu Lys Val Asp Ser Ser Xaa Asn Ser Ser 
            100                 105                 110         


Pro Ser Pro Gln Gln Ser Glu Ser Leu Ser Pro Ala His Xaa Ser Asp 
        115                 120                 125             


Phe Arg Xaa Asp Asp Ser Gln Pro Pro Xaa Leu Gly Gln Glu Ile Leu 
    130                 135                 140                 


Glu Glu Pro Ser Leu Pro Ser Ser Glu Val Ala Asp Glu Pro Pro Xaa 
145                 150                 155                 160 


Leu Xaa Lys Glu Glu Pro Val Pro Leu Glu Xaa Gln Val Val Glu Glu 
                165                 170                 175     


Glu Glu Asp Ser Gly Ala Pro Pro Leu Lys Arg Phe Cys Val Asp Gln 
            180                 185                 190         


Pro Xaa Val Pro Gln Xaa Ala Ser Glu Ser 
        195                 200         


<210> 4121
<211> 145
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<400> 4121
Met Ser Gly Arg Ser Val Arg Ala Glu Xaa Arg Ser Arg Ala Lys Asp 
1               5                   10                  15      


Asp Ile Lys Lys Val Met Ala Ala Ile Glu Lys Val Arg Lys Trp Glu 
            20                  25                  30          


Lys Lys Trp Val Xaa Val Gly Asp Xaa Ser Leu Arg Ile Phe Lys Trp 
        35                  40                  45              


Val Pro Val Xaa Asp Ser Lys Glu Lys Glu Lys Ser Lys Ser Asn Ser 
    50                  55                  60                  


Ser Ala Ala Arg Glu Pro Asn Gly Phe Pro Ser Asp Ala Ser Ala Asn 
65                  70                  75                  80  


Ser Ser Leu Leu Leu Glu Phe Gln Glu Pro Ser Leu Pro Ser Ser Glu 
                85                  90                  95      


Val Ala Asp Glu Pro Pro Xaa Leu Xaa Lys Glu Glu Pro Val Pro Leu 
            100                 105                 110         


Glu Xaa Gln Val Val Glu Glu Glu Glu Asp Ser Gly Ala Pro Pro Leu 
        115                 120                 125             


Lys Arg Phe Cys Val Asp Gln Pro Xaa Val Pro Gln Xaa Ala Ser Glu 
    130                 135                 140                 


Ser 
145 


<210> 4122
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 4122
Met Ser Gly Arg Ser Val Arg Ala Glu Xaa Arg Ser Arg Ala Lys Asp 
1               5                   10                  15      


Asp Ile Lys Lys Val Met Ala Ala Ile Glu Lys Val Arg Lys Trp Glu 
            20                  25                  30          


Lys Lys Trp Val Xaa Val Gly Asp Xaa Ser Leu Arg Ile Phe Lys Trp 
        35                  40                  45              


Val Pro Val Xaa Asp Ser Lys Glu Arg Gln Ser Leu Ala Met Leu Ser 
    50                  55                  60                  


Arg Leu Val Val Asn Ser Trp Pro Gln Ala Val Pro Gln Pro 
65                  70                  75              


<210> 4123
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 4123
Met Ser Gly Arg Ser Val Arg Ala Glu Xaa Arg Ser Arg Ala Lys Asp 
1               5                   10                  15      


Asp Ile Lys Lys Val Met Ala Ala Ile Glu Lys Val Arg Lys Trp Glu 
            20                  25                  30          


Lys Lys Trp Val Xaa Val Gly Asp Xaa Ser Leu Arg Ile Phe Lys Trp 
        35                  40                  45              


Val Pro Val Xaa Asp Ser Lys Glu Xaa Lys Xaa Ala Xaa Arg Val Pro 
    50                  55                  60                  


Cys Leu Xaa Ser Ile Ser Leu Arg Trp Xaa Ala Ala Pro Xaa Gln Ala 
65                  70                  75                  80  


Pro Ala Pro Ser Arg Val Ser Pro 
                85              


<210> 4124
<211> 213
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<400> 4124
Met Xaa Glu Ser Arg Ser Val Xaa Gln Ala Gly Val His Trp Arg Asn 
1               5                   10                  15      


Leu Gly Ser Leu Gln Pro Leu Pro Leu Arg Phe Lys Gln Phe Ser Cys 
            20                  25                  30          


Leu Ser Leu Leu Ser Ser Trp Asp Tyr Arg Glu Lys Lys Trp Val Xaa 
        35                  40                  45              


Val Gly Asp Xaa Ser Leu Arg Ile Phe Lys Trp Val Pro Val Xaa Asp 
    50                  55                  60                  


Ser Lys Glu Lys Glu Lys Ser Lys Ser Asn Ser Ser Ala Ala Arg Glu 
65                  70                  75                  80  


Pro Asn Gly Phe Pro Ser Asp Ala Ser Ala Asn Ser Ser Leu Leu Leu 
                85                  90                  95      


Glu Phe Gln Asp Glu Asn Ser Asn Gln Ser Ser Val Ser Asp Val Tyr 
            100                 105                 110         


Gln Leu Lys Val Asp Ser Ser Xaa Asn Ser Ser Pro Ser Pro Gln Gln 
        115                 120                 125             


Ser Glu Ser Leu Ser Pro Ala His Xaa Ser Asp Phe Arg Xaa Asp Asp 
    130                 135                 140                 


Ser Gln Pro Pro Xaa Leu Gly Gln Glu Ile Leu Glu Glu Pro Ser Leu 
145                 150                 155                 160 


Pro Ser Ser Glu Val Ala Asp Glu Pro Pro Xaa Leu Xaa Lys Glu Glu 
                165                 170                 175     


Pro Val Pro Leu Glu Xaa Gln Val Val Glu Glu Glu Glu Asp Ser Gly 
            180                 185                 190         


Ala Pro Pro Leu Lys Arg Phe Cys Val Asp Gln Pro Xaa Val Pro Gln 
        195                 200                 205             


Xaa Ala Ser Glu Ser 
    210             


<210> 4125
<211> 1426
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1083)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1248)..(1248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1299)..(1299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1306)..(1306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1340)..(1340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1346)..(1346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<400> 4125
Met His Ser Ser Asn Pro Lys Val Arg Ser Ser Pro Ser Gly Asn Xaa 
1               5                   10                  15      


Gln Ser Ser Pro Lys Ser Lys Gln Glu Val Met Val Arg Pro Pro Xaa 
            20                  25                  30          


Val Met Ser Pro Ser Gly Asn Pro Gln Leu Asp Ser Lys Phe Ser Asn 
        35                  40                  45              


Gln Gly Lys Gln Gly Gly Ser Ala Ser Gln Ser Gln Pro Ser Pro Cys 
    50                  55                  60                  


Asp Ser Lys Ser Gly Gly His Xaa Pro Lys Ala Leu Pro Gly Pro Gly 
65                  70                  75                  80  


Gly Ser Met Gly Leu Lys Asn Gly Ala Gly Asn Gly Ala Lys Gly Lys 
                85                  90                  95      


Gly Lys Arg Glu Arg Ser Ile Ser Ala Asp Ser Phe Asp Gln Arg Asp 
            100                 105                 110         


Pro Gly Xaa Pro Asn Asp Asp Ser Asp Ile Lys Glu Cys Asn Ser Ala 
        115                 120                 125             


Asp His Ile Lys Ser Gln Asp Ser Gln His Xaa Pro His Ser Met Xaa 
    130                 135                 140                 


Pro Ser Asn Ala Xaa Ala Pro Arg Ser Ser Xaa Pro Ser His Gly Gln 
145                 150                 155                 160 


Xaa Xaa Ala Xaa Glu Pro Xaa Pro Ala Gln Lys Xaa Pro Ala Lys Val 
                165                 170                 175     


Val Tyr Val Phe Ser Xaa Glu Met Ala Asn Lys Ala Ala Glu Ala Val 
            180                 185                 190         


Leu Lys Gly Gln Val Glu Xaa Ile Val Ser Phe His Ile Gln Asn Ile 
        195                 200                 205             


Ser Asn Asn Lys Xaa Glu Arg Ser Xaa Ala Pro Leu Asn Xaa Gln Ile 
    210                 215                 220                 


Ser Ala Leu Arg Asn Asp Pro Lys Pro Leu Pro Gln Gln Pro Pro Ala 
225                 230                 235                 240 


Pro Ala Asn Gln Asp Gln Asn Ser Ser Gln Asn Xaa Arg Leu Gln Pro 
                245                 250                 255     


Xaa Pro Pro Ile Pro Ala Pro Ala Pro Lys Pro Ala Ala Pro Pro Arg 
            260                 265                 270         


Pro Leu Asp Arg Glu Ser Pro Gly Val Glu Asn Lys Leu Ile Pro Ser 
        275                 280                 285             


Val Gly Ser Pro Ala Ser Ser Xaa Pro Leu Pro Pro Asp Gly Xaa Gly 
    290                 295                 300                 


Pro Asn Ser Xaa Pro Asn Asn Arg Ala Val Xaa Pro Val Ser Gln Gly 
305                 310                 315                 320 


Ser Asn Ser Ser Ser Ala Asp Pro Lys Ala Pro Pro Pro Pro Pro Val 
                325                 330                 335     


Ser Ser Gly Glu Pro Pro Xaa Leu Gly Glu Asn Pro Asp Gly Leu Ser 
            340                 345                 350         


Gln Glu Gln Leu Glu His Arg Glu Arg Ser Leu Gln Xaa Leu Arg Asp 
        355                 360                 365             


Ile Gln Arg Met Leu Phe Pro Asp Glu Lys Glu Phe Xaa Gly Ala Gln 
    370                 375                 380                 


Ser Gly Gly Pro Gln Gln Asn Pro Gly Val Leu Asp Gly Pro Gln Lys 
385                 390                 395                 400 


Lys Pro Glu Gly Pro Ile Gln Ala Met Met Ala Gln Ser Gln Ser Leu 
                405                 410                 415     


Gly Lys Gly Pro Gly Pro Arg Xaa Asp Val Gly Ala Pro Phe Gly Pro 
            420                 425                 430         


Gln Gly His Arg Asp Val Pro Phe Ser Pro Asp Glu Met Val Pro Pro 
        435                 440                 445             


Ser Met Asn Ser Gln Ser Gly Xaa Ile Gly Pro Asp His Leu Asp His 
    450                 455                 460                 


Met Xaa Pro Glu Gln Ile Ala Trp Leu Lys Leu Gln Gln Glu Phe Tyr 
465                 470                 475                 480 


Glu Glu Lys Arg Arg Lys Gln Glu Gln Val Val Val Gln Gln Cys Ser 
                485                 490                 495     


Leu Gln Asp Met Met Val His Gln His Gly Pro Arg Gly Val Val Arg 
            500                 505                 510         


Gly Pro Pro Pro Pro Tyr Gln Met Xaa Pro Ser Glu Gly Trp Ala Pro 
        515                 520                 525             


Gly Gly Xaa Glu Pro Phe Ser Asp Gly Ile Asn Met Pro His Ser Leu 
    530                 535                 540                 


Pro Pro Arg Gly Met Ala Pro His Pro Asn Met Pro Gly Ser Gln Met 
545                 550                 555                 560 


Arg Leu Pro Gly Phe Ala Gly Met Ile Asn Ser Glu Met Glu Gly Pro 
                565                 570                 575     


Asn Val Pro Asn Pro Ala Ser Arg Pro Gly Leu Ser Gly Val Ser Trp 
            580                 585                 590         


Pro Asp Asp Val Pro Lys Ile Pro Asp Gly Arg Asn Phe Pro Pro Gly 
        595                 600                 605             


Gln Gly Ile Phe Ser Gly Pro Gly Arg Gly Glu Arg Phe Pro Asn Pro 
    610                 615                 620                 


Gln Gly Leu Ser Glu Glu Met Phe Gln Gln Gln Leu Ala Glu Lys Gln 
625                 630                 635                 640 


Leu Gly Leu Pro Pro Gly Met Ala Met Glu Gly Ile Arg Pro Ser Met 
                645                 650                 655     


Glu Met Asn Arg Met Ile Pro Gly Ser Gln Arg His Met Glu Pro Gly 
            660                 665                 670         


Asn Asn Pro Ile Phe Pro Arg Ile Pro Val Glu Gly Pro Leu Ser Pro 
        675                 680                 685             


Ser Arg Gly Asp Phe Pro Lys Gly Ile Pro Pro Gln Met Gly Pro Gly 
    690                 695                 700                 


Arg Glu Leu Glu Phe Gly Met Val Pro Ser Gly Met Lys Gly Asp Val 
705                 710                 715                 720 


Asn Leu Asn Val Asn Met Gly Ser Asn Ser Gln Met Ile Pro Gln Lys 
                725                 730                 735     


Met Arg Glu Ala Gly Ala Gly Pro Glu Glu Met Leu Lys Leu Arg Pro 
            740                 745                 750         


Gly Gly Ser Asp Met Leu Pro Ala Gln Gln Lys Met Val Pro Leu Pro 
        755                 760                 765             


Phe Gly Glu His Pro Gln Gln Glu Tyr Gly Met Gly Pro Arg Pro Phe 
    770                 775                 780                 


Leu Pro Met Ser Gln Gly Pro Gly Ser Asn Ser Gly Leu Arg Asn Leu 
785                 790                 795                 800 


Arg Glu Pro Ile Gly Pro Asp Gln Arg Xaa Asn Ser Arg Leu Ser His 
                805                 810                 815     


Met Pro Pro Leu Pro Leu Asn Pro Ser Ser Asn Pro Xaa Ser Leu Asn 
            820                 825                 830         


Xaa Ala Pro Pro Val Gln Arg Gly Leu Gly Arg Lys Pro Leu Asp Ile 
        835                 840                 845             


Ser Val Ala Gly Ser Gln Val His Ser Pro Gly Ile Asn Pro Leu Lys 
    850                 855                 860                 


Ser Pro Xaa Met His Gln Val Gln Ser Pro Met Leu Gly Ser Pro Ser 
865                 870                 875                 880 


Gly Asn Leu Lys Ser Pro Gln Xaa Pro Ser Gln Leu Ala Gly Met Leu 
                885                 890                 895     


Ala Gly Pro Ala Ala Ala Ala Ser Ile Lys Ser Pro Pro Val Leu Gly 
            900                 905                 910         


Ser Ala Ala Ala Ser Pro Val His Leu Lys Ser Pro Ser Leu Pro Ala 
        915                 920                 925             


Pro Ser Pro Gly Trp Xaa Ser Ser Pro Lys Pro Pro Leu Gln Ser Pro 
    930                 935                 940                 


Gly Ile Pro Pro Asn His Lys Ala Pro Leu Xaa Met Ala Ser Pro Ala 
945                 950                 955                 960 


Met Leu Gly Asn Val Glu Ser Gly Gly Pro Pro Pro Pro Xaa Ala Ser 
                965                 970                 975     


Gln Pro Ala Ser Val Asn Ile Pro Gly Ser Leu Pro Ser Ser Xaa Pro 
            980                 985                 990         


Tyr Xaa Met Pro Pro Glu Pro Xaa  Leu Ser Gln Asn Pro  Leu Ser Ile 
        995                 1000                 1005             


Met Met  Ser Arg Met Ser Lys  Phe Ala Met Pro Ser  Ser Xaa Pro 
    1010                 1015                 1020             


Leu Tyr  His Asp Ala Ile Lys  Xaa Val Ala Ser Ser  Asp Asp Asp 
    1025                 1030                 1035             


Ser Pro  Pro Ala Arg Ser Pro  Asn Leu Pro Ser Met  Asn Asn Met 
    1040                 1045                 1050             


Pro Gly  Met Gly Ile Asn Xaa  Gln Asn Pro Arg Ile  Ser Gly Pro 
    1055                 1060                 1065             


Asn Pro  Val Val Pro Met Pro  Xaa Leu Ser Pro Met  Gly Met Xaa 
    1070                 1075                 1080             


Gln Pro  Leu Ser His Ser Asn  Gln Met Pro Ser Pro  Asn Ala Val 
    1085                 1090                 1095             


Gly Pro  Asn Ile Pro Pro His  Gly Val Pro Met Gly  Pro Gly Leu 
    1100                 1105                 1110             


Met Ser  His Asn Pro Ile Met  Gly His Gly Ser Gln  Glu Pro Pro 
    1115                 1120                 1125             


Met Val  Pro Gln Gly Arg Met  Gly Phe Pro Gln Gly  Phe Pro Pro 
    1130                 1135                 1140             


Val Gln  Ser Pro Pro Gln Gln  Val Pro Phe Pro His  Asn Gly Pro 
    1145                 1150                 1155             


Ser Gly  Gly Gln Gly Ser Phe  Pro Gly Gly Met Gly  Phe Pro Gly 
    1160                 1165                 1170             


Glu Gly  Pro Leu Gly Arg Pro  Ser Asn Leu Pro Gln  Ser Ser Ala 
    1175                 1180                 1185             


Asp Ala  Ala Leu Cys Lys Pro  Gly Gly Pro Gly Gly  Pro Asp Ser 
    1190                 1195                 1200             


Phe Xaa  Val Leu Gly Asn Ser  Met Pro Ser Val Phe  Xaa Asp Pro 
    1205                 1210                 1215             


Asp Leu  Gln Glu Val Ile Arg  Pro Gly Ala Xaa Gly  Ile Pro Glu 
    1220                 1225                 1230             


Phe Asp  Leu Ser Arg Ile Ile  Pro Ser Glu Lys Pro  Ser Gln Xaa 
    1235                 1240                 1245             


Leu Gln  Tyr Phe Pro Arg Gly  Glu Val Pro Gly Arg  Lys Gln Pro 
    1250                 1255                 1260             


Gln Gly  Pro Gly Pro Gly Phe  Ser His Met Gln Gly  Met Met Gly 
    1265                 1270                 1275             


Glu Gln  Ala Pro Arg Met Gly  Leu Ala Leu Pro Gly  Met Gly Gly 
    1280                 1285                 1290             


Pro Gly  Pro Val Gly Xaa Pro  Asp Ile Pro Leu Gly  Xaa Ala Pro 
    1295                 1300                 1305             


Ser Met  Pro Gly His Asn Pro  Met Arg Pro Pro Ala  Phe Leu Gln 
    1310                 1315                 1320             


Gln Gly  Met Met Gly Pro His  His Arg Met Met Ser  Pro Ala Gln 
    1325                 1330                 1335             


Ser Xaa  Met Pro Gly Gln Pro  Xaa Leu Met Ser Asn  Pro Ala Ala 
    1340                 1345                 1350             


Ala Val  Gly Met Ile Pro Gly  Lys Asp Arg Gly Pro  Ala Gly Leu 
    1355                 1360                 1365             


Tyr Xaa  His Pro Gly Pro Val  Gly Ser Pro Gly Met  Met Met Ser 
    1370                 1375                 1380             


Met Gln  Gly Met Met Gly Pro  Gln Gln Asn Ile Met  Ile Pro Pro 
    1385                 1390                 1395             


Gln Met  Arg Pro Arg Gly Met  Ala Ala Asp Val Gly  Met Gly Gly 
    1400                 1405                 1410             


Phe Ser  Gln Gly Pro Gly Asn  Pro Gly Asn Met Met  Phe 
    1415                 1420                 1425     


<210> 4126
<211> 1462
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1280)..(1280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1282)..(1282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1366)..(1366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1392)..(1392)
<223> Selenocysteine

<400> 4126
Met His Pro Glu Asn Lys Leu Xaa Asn His Gly Lys Xaa Gly Asn Gly 
1               5                   10                  15      


Gly Ala Gln Ser Gln His Gln Asn Val Asn Gln Gly Pro Xaa Cys Asn 
            20                  25                  30          


Val Gly Ser Lys Gly Val Gly Ala Gly Asn His Gly Ala Lys Ala Asn 
        35                  40                  45              


Gln Ile Ser Pro Ser Asn Ser Ser Leu Lys Asn Pro Gln Ala Gly Val 
    50                  55                  60                  


Pro Pro Phe Ser Ser Leu Lys Gly Lys Val Lys Arg Asp Arg Ser Val 
65                  70                  75                  80  


Ser Val Asp Ser Gly Glu Gln Arg Glu Ala Gly Xaa Pro Ser Leu Asp 
                85                  90                  95      


Ser Glu Ala Lys Glu Val Ala Pro Arg Ser Lys Arg Arg Cys Val Leu 
            100                 105                 110         


Glu Arg Lys Gln Pro Tyr Ser Gly Asp Glu Trp Cys Ser Gly Pro Asp 
        115                 120                 125             


Ser Glu Glu Asp Asp Lys Pro Ile Gly Ala Xaa His Asn Cys Asn Val 
    130                 135                 140                 


Ala Asp Pro Ala Met Ala Ala Pro Gln Leu Gly Pro Gly Gln Xaa Xaa 
145                 150                 155                 160 


Gln Leu Pro Leu Ser Glu Ser Ser Val Pro Gly Ala Pro His Gly Pro 
                165                 170                 175     


Pro Pro Gly Leu Arg Pro Asp Ala Pro Gly Gly Gly Gly Gly Gly Gly 
            180                 185                 190         


Gly Val Pro Gly Lys Pro Pro Ser Gln Phe Val Tyr Val Phe Xaa Xaa 
        195                 200                 205             


His Leu Ala Asn Xaa Ala Ala Glu Ala Val Leu Gln Gly Arg Ala Asp 
    210                 215                 220                 


Ser Ile Leu Ala Tyr His Gln Gln Asn Val Pro Arg Ala Lys Leu Asp 
225                 230                 235                 240 


Gln Ala Pro Lys Val Pro Pro Xaa Pro Glu Pro Leu Pro Leu Ser Xaa 
                245                 250                 255     


Pro Ser Ala Gly Xaa Pro Gln Ser Gln Pro Pro Pro Leu Pro Pro Pro 
            260                 265                 270         


Pro Pro Pro Ala Pro Gly Ser Ala Pro Pro Ala Leu Pro Pro Glu Gly 
        275                 280                 285             


Pro Pro Glu Asp Ser Ser Gln Asp Leu Ala Pro Asn Ser Val Gly Ala 
    290                 295                 300                 


Ala Ser Xaa Gly Gly Gly Xaa Gly Gly Xaa His Pro Asn Xaa Pro Xaa 
305                 310                 315                 320 


Ala Xaa Xaa Ala Asn Asn Pro Leu Pro Pro Gly Gly Asp Pro Ser Ser 
                325                 330                 335     


Ala Pro Gly Pro Ala Leu Leu Gly Glu Ala Ala Ala Pro Gly Asn Gly 
            340                 345                 350         


Gln Arg Ser Leu Val Gly Ser Glu Gly Leu Ser Lys Glu Gln Leu Glu 
        355                 360                 365             


His Arg Glu Arg Ser Leu Gln Xaa Leu Arg Asp Ile Glu Arg Leu Leu 
    370                 375                 380                 


Leu Arg Ser Gly Glu Xaa Glu Pro Phe Leu Lys Gly Pro Pro Gly Gly 
385                 390                 395                 400 


Ala Gly Glu Gly Gly Pro Pro Ala Gln Ala Pro Pro Pro Pro Gln Gln 
                405                 410                 415     


Pro Pro Xaa Ala Pro Pro Ser Gly Leu Lys Lys Tyr Glu Glu Pro Leu 
            420                 425                 430         


Gln Ser Met Ile Ser Gln Xaa Gln Ser Leu Gly Gly Pro Pro Leu Glu 
        435                 440                 445             


His Glu Val Pro Gly His Pro Pro Gly Gly Asp Met Gly Gln Gln Met 
    450                 455                 460                 


Asn Met Met Ile Gln Arg Leu Gly Gln Asp Ser Leu Xaa Pro Glu Gln 
465                 470                 475                 480 


Val Ala Trp Arg Lys Leu Gln Glu Glu Tyr Tyr Glu Glu Lys Arg Arg 
                485                 490                 495     


Lys Glu Glu Gln Ile Gly Leu His Gly Ser Arg Pro Leu Gln Asp Met 
            500                 505                 510         


Met Gly Met Gly Gly Met Met Val Arg Gly Pro Pro Pro Pro Tyr His 
        515                 520                 525             


Ser Lys Pro Gly Asp Gln Trp Pro Pro Gly Met Gly Ala Gln Leu Arg 
    530                 535                 540                 


Gly Pro Met Asp Val Gln Asp Pro Met Gln Leu Arg Gly Gly Pro Pro 
545                 550                 555                 560 


Phe Pro Gly Pro Arg Phe Pro Gly Asn Gln Ile Gln Arg Val Pro Gly 
                565                 570                 575     


Phe Gly Gly Met Gln Ser Met Pro Met Glu Val Pro Met Asn Ala Met 
            580                 585                 590         


Gln Arg Pro Val Arg Pro Gly Met Gly Trp Xaa Glu Asp Leu Pro Pro 
        595                 600                 605             


Met Gly Gly Pro Ser Asn Phe Ala Gln Asn Xaa Met Pro Tyr Pro Gly 
    610                 615                 620                 


Gly Gln Gly Glu Ala Glu Arg Phe Met Xaa Pro Arg Val Arg Glu Glu 
625                 630                 635                 640 


Leu Leu Arg His Gln Leu Leu Glu Lys Arg Ser Met Gly Met Gln Arg 
                645                 650                 655     


Pro Leu Gly Met Ala Gly Ser Gly Met Gly Gln Ser Met Glu Met Glu 
            660                 665                 670         


Arg Met Met Gln Ala His Arg Gln Met Asp Pro Ala Met Phe Pro Gly 
        675                 680                 685             


Gln Met Ala Gly Gly Glu Gly Leu Ala Gly Xaa Pro Met Gly Met Glu 
    690                 695                 700                 


Phe Gly Gly Gly Arg Gly Leu Leu Ser Pro Pro Met Gly Gln Ser Gly 
705                 710                 715                 720 


Leu Arg Glu Val Asp Pro Pro Met Gly Pro Gly Asn Leu Asn Met Asn 
                725                 730                 735     


Met Asn Val Asn Met Asn Met Asn Met Asn Leu Asn Val Gln Met Xaa 
            740                 745                 750         


Pro Gln Gln Gln Met Leu Met Ser Gln Lys Met Arg Gly Pro Gly Asp 
        755                 760                 765             


Leu Met Gly Pro Gln Gly Leu Ser Pro Glu Glu Met Ala Arg Val Arg 
    770                 775                 780                 


Ala Gln Asn Ser Ser Gly Val Met Gly Gly Pro Gln Lys Met Leu Met 
785                 790                 795                 800 


Pro Ser Gln Phe Pro Asn Gln Gly Gln Gln Gly Phe Ser Gly Gly Gln 
                805                 810                 815     


Gly Pro Tyr Gln Ala Met Ser Gln Asp Met Gly Asn Xaa Gln Asp Met 
            820                 825                 830         


Phe Ser Pro Asp Gln Ser Ser Met Pro Met Ser Asn Val Gly Xaa Xaa 
        835                 840                 845             


Arg Leu Ser His Met Pro Leu Pro Pro Ala Ser Asn Pro Pro Gly Xaa 
    850                 855                 860                 


Val His Ser Ala Pro Asn Arg Gly Leu Gly Arg Arg Pro Ser Asp Leu 
865                 870                 875                 880 


Xaa Ile Ser Ile Asn Gln Met Gly Ser Pro Gly Met Gly His Leu Lys 
                885                 890                 895     


Ser Pro Xaa Leu Ser Gln Val His Ser Pro Leu Val Xaa Ser Pro Ser 
            900                 905                 910         


Ala Asn Leu Lys Ser Pro Gln Xaa Pro Ser Gln Met Val Pro Leu Pro 
        915                 920                 925             


Ser Ala Asn Pro Pro Gly Pro Leu Lys Ser Pro Gln Val Leu Gly Ser 
    930                 935                 940                 


Ser Leu Ser Val Arg Ser Pro Xaa Gly Ser Pro Ser Arg Leu Lys Ser 
945                 950                 955                 960 


Pro Ser Met Ala Val Pro Ser Pro Gly Trp Val Ala Ser Pro Lys Xaa 
                965                 970                 975     


Ala Met Pro Ser Pro Gly Val Ser Gln Asn Lys Gln Pro Pro Leu Asn 
            980                 985                 990         


Met Asn Ser Ser Xaa Xaa Leu Ser  Asn Met Glu Gln Gly  Xaa Leu Pro 
        995                 1000                 1005             


Pro Ser  Gly Pro Arg Ser Ser  Ser Ser Ala Pro Pro  Ala Asn Pro 
    1010                 1015                 1020             


Pro Ser  Gly Leu Met Asn Pro  Ser Leu Pro Phe Xaa  Ser Ser Pro 
    1025                 1030                 1035             


Asp Pro  Xaa Pro Ser Gln Asn  Pro Leu Ser Leu Met  Met Xaa Gln 
    1040                 1045                 1050             


Met Ser  Lys Tyr Ala Met Pro  Ser Ser Xaa Pro Leu  Tyr His Asn 
    1055                 1060                 1065             


Ala Ile  Lys Xaa Ile Ala Xaa  Ser Asp Asp Glu Leu  Leu Pro Asp 
    1070                 1075                 1080             


Arg Pro  Leu Leu Pro Pro Pro  Pro Pro Pro Gln Gly  Ser Gly Pro 
    1085                 1090                 1095             


Gly Ile  Ser Asn Ser Gln Pro  Ser Gln Met His Leu  Asn Ser Ala 
    1100                 1105                 1110             


Ala Ala  Gln Ser Pro Met Gly  Met Asn Leu Pro Gly  Gln Gln Pro 
    1115                 1120                 1125             


Leu Ser  His Glu Pro Pro Pro  Ala Met Leu Pro Ser  Pro Xaa Pro 
    1130                 1135                 1140             


Leu Gly  Ser Asn Ile Pro Leu  His Pro Asn Ala Gln  Gly Xaa Gly 
    1145                 1150                 1155             


Gly Pro  Pro Gln Asn Ser Met  Met Met Ala Pro Gly  Gly Pro Asp 
    1160                 1165                 1170             


Ser Leu  Asn Ala Pro Cys Gly  Pro Val Pro Ser Ser  Ser Gln Met 
    1175                 1180                 1185             


Met Pro  Phe Pro Pro Arg Leu  Gln Gln Pro His Gly  Ala Met Ala 
    1190                 1195                 1200             


Pro Xaa  Gly Gly Gly Gly Gly  Gly Pro Gly Leu Gln  Gln His Tyr 
    1205                 1210                 1215             


Pro Ser  Gly Met Ala Leu Pro  Pro Glu Asp Leu Pro  Asn Gln Pro 
    1220                 1225                 1230             


Pro Gly  Pro Met Pro Pro Gln  Gln His Leu Met Gly  Lys Ala Met 
    1235                 1240                 1245             


Ala Gly  Arg Met Gly Asp Ala  Tyr Pro Pro Gly Val  Leu Pro Gly 
    1250                 1255                 1260             


Val Ala  Ser Val Leu Asn Asp  Pro Glu Leu Ser Glu  Val Ile Arg 
    1265                 1270                 1275             


Pro Xaa  Pro Xaa Gly Ile Pro  Glu Phe Asp Leu Ser  Arg Ile Ile 
    1280                 1285                 1290             


Pro Ser  Glu Lys Pro Ser Ser  Xaa Leu Gln Tyr Phe  Pro Lys Ser 
    1295                 1300                 1305             


Glu Asn  Gln Pro Pro Lys Ala  Gln Pro Pro Asn Leu  His Leu Met 
    1310                 1315                 1320             


Asn Leu  Gln Asn Met Met Ala  Glu Gln Xaa Pro Ser  Arg Pro Pro 
    1325                 1330                 1335             


Asn Leu  Pro Gly Gln Gln Gly  Val Gln Arg Gly Leu  Asn Met Ser 
    1340                 1345                 1350             


Met Cys  His Pro Gly Gln Met  Ser Leu Leu Gly Arg  Xaa Gly Val 
    1355                 1360                 1365             


Pro Pro  Gln Gln Gly Met Val  Pro His Gly Leu His  Gln Gly Val 
    1370                 1375                 1380             


Met Ser  Pro Pro Gln Gly Leu  Met Xaa Gln Gln Asn  Phe Met Leu 
    1385                 1390                 1395             


Met Lys  Gln Arg Gly Val Gly  Gly Glu Val Tyr Ser  Gln Pro Pro 
    1400                 1405                 1410             


His Met  Leu Ser Pro Gln Gly  Ser Leu Met Gly Pro  Pro Pro Gln 
    1415                 1420                 1425             


Gln Asn  Leu Met Val Ser His  Pro Leu Arg Gln Arg  Ser Val Ser 
    1430                 1435                 1440             


Leu Asp  Ser Gln Met Gly Tyr  Leu Pro Ala Pro Gly  Gly Met Ala 
    1445                 1450                 1455             


Asn Leu  Pro Phe 
    1460         


<210> 4127
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<400> 4127
Met Arg Ile Leu Ala Asn Lys Xaa Arg Leu Pro His Pro Arg Arg Arg 
1               5                   10                  15      


Glu Ala Pro Gly Ser Pro Pro Leu Ser Pro Arg Gly His Cys Pro Pro 
            20                  25                  30          


Ala Pro Ala Lys Pro Met His Pro Glu Asn Lys Leu Xaa Asn His Gly 
        35                  40                  45              


Lys Xaa Gly Asn Gly Gly Ala Gln Ser Gln His Gln Asn Val Asn Gln 
    50                  55                  60                  


Gly Pro Xaa Cys Asn Val Gly Ser Lys Gly Val Gly Ala Gly Asn His 
65                  70                  75                  80  


Gly Ala Lys Ala Asn Gln Ile Ser 
                85              


<210> 4128
<211> 1499
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1179)..(1179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1317)..(1317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1319)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1338)..(1338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1403)..(1403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1429)..(1429)
<223> Selenocysteine

<400> 4128
Met Arg Ile Leu Ala Asn Lys Xaa Arg Leu Pro His Pro Arg Arg Arg 
1               5                   10                  15      


Glu Ala Pro Gly Ser Pro Pro Leu Ser Pro Arg Gly His Cys Pro Pro 
            20                  25                  30          


Ala Pro Ala Lys Pro Met His Pro Glu Asn Lys Leu Xaa Asn His Gly 
        35                  40                  45              


Lys Xaa Gly Asn Gly Gly Ala Gln Ser Gln His Gln Asn Val Asn Gln 
    50                  55                  60                  


Gly Pro Xaa Cys Asn Val Gly Ser Lys Gly Val Gly Ala Gly Asn His 
65                  70                  75                  80  


Gly Ala Lys Ala Asn Gln Ile Ser Pro Ser Asn Ser Ser Leu Lys Asn 
                85                  90                  95      


Pro Gln Ala Gly Val Pro Pro Phe Ser Ser Leu Lys Gly Lys Val Lys 
            100                 105                 110         


Arg Asp Arg Ser Val Ser Val Asp Ser Gly Glu Gln Arg Glu Ala Gly 
        115                 120                 125             


Xaa Pro Ser Leu Asp Ser Glu Ala Lys Glu Val Ala Pro Arg Ser Lys 
    130                 135                 140                 


Arg Arg Cys Val Leu Glu Arg Lys Gln Pro Tyr Ser Gly Asp Glu Trp 
145                 150                 155                 160 


Cys Ser Gly Pro Asp Ser Glu Glu Asp Asp Lys Pro Ile Gly Ala Xaa 
                165                 170                 175     


His Asn Cys Asn Val Ala Asp Pro Ala Met Ala Ala Pro Gln Leu Gly 
            180                 185                 190         


Pro Gly Gln Xaa Xaa Gln Leu Pro Leu Ser Glu Ser Ser Val Pro Gly 
        195                 200                 205             


Ala Pro His Gly Pro Pro Pro Gly Leu Arg Pro Asp Ala Pro Gly Gly 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Val Pro Gly Lys Pro Pro Ser Gln Phe Val 
225                 230                 235                 240 


Tyr Val Phe Xaa Xaa His Leu Ala Asn Xaa Ala Ala Glu Ala Val Leu 
                245                 250                 255     


Gln Gly Arg Ala Asp Ser Ile Leu Ala Tyr His Gln Gln Asn Val Pro 
            260                 265                 270         


Arg Ala Lys Leu Asp Gln Ala Pro Lys Val Pro Pro Xaa Pro Glu Pro 
        275                 280                 285             


Leu Pro Leu Ser Xaa Pro Ser Ala Gly Xaa Pro Gln Ser Gln Pro Pro 
    290                 295                 300                 


Pro Leu Pro Pro Pro Pro Pro Pro Ala Pro Gly Ser Ala Pro Pro Ala 
305                 310                 315                 320 


Leu Pro Pro Glu Gly Pro Pro Glu Asp Ser Ser Gln Asp Leu Ala Pro 
                325                 330                 335     


Asn Ser Val Gly Ala Ala Ser Xaa Gly Gly Gly Xaa Gly Gly Xaa His 
            340                 345                 350         


Pro Asn Xaa Pro Xaa Ala Xaa Xaa Ala Asn Asn Pro Leu Pro Pro Gly 
        355                 360                 365             


Gly Asp Pro Ser Ser Ala Pro Gly Pro Ala Leu Leu Gly Glu Ala Ala 
    370                 375                 380                 


Ala Pro Gly Asn Gly Gln Arg Ser Leu Val Gly Ser Glu Gly Leu Ser 
385                 390                 395                 400 


Lys Glu Gln Leu Glu His Arg Glu Arg Ser Leu Gln Xaa Leu Arg Asp 
                405                 410                 415     


Ile Glu Arg Leu Leu Leu Arg Ser Gly Glu Xaa Glu Pro Phe Leu Lys 
            420                 425                 430         


Gly Pro Pro Gly Gly Ala Gly Glu Gly Gly Pro Pro Ala Gln Ala Pro 
        435                 440                 445             


Pro Pro Pro Gln Gln Pro Pro Xaa Ala Pro Pro Ser Gly Leu Lys Lys 
    450                 455                 460                 


Tyr Glu Glu Pro Leu Gln Ser Met Ile Ser Gln Xaa Gln Ser Leu Gly 
465                 470                 475                 480 


Gly Pro Pro Leu Glu His Glu Val Pro Gly His Pro Pro Gly Gly Asp 
                485                 490                 495     


Met Gly Gln Gln Met Asn Met Met Ile Gln Arg Leu Gly Gln Asp Ser 
            500                 505                 510         


Leu Xaa Pro Glu Gln Val Ala Trp Arg Lys Leu Gln Glu Glu Tyr Tyr 
        515                 520                 525             


Glu Glu Lys Arg Arg Lys Glu Glu Gln Ile Gly Leu His Gly Ser Arg 
    530                 535                 540                 


Pro Leu Gln Asp Met Met Gly Met Gly Gly Met Met Val Arg Gly Pro 
545                 550                 555                 560 


Pro Pro Pro Tyr His Ser Lys Pro Gly Asp Gln Trp Pro Pro Gly Met 
                565                 570                 575     


Gly Ala Gln Leu Arg Gly Pro Met Asp Val Gln Asp Pro Met Gln Leu 
            580                 585                 590         


Arg Gly Gly Pro Pro Phe Pro Gly Pro Arg Phe Pro Gly Asn Gln Ile 
        595                 600                 605             


Gln Arg Val Pro Gly Phe Gly Gly Met Gln Ser Met Pro Met Glu Val 
    610                 615                 620                 


Pro Met Asn Ala Met Gln Arg Pro Val Arg Pro Gly Met Gly Trp Xaa 
625                 630                 635                 640 


Glu Asp Leu Pro Pro Met Gly Gly Pro Ser Asn Phe Ala Gln Asn Xaa 
                645                 650                 655     


Met Pro Tyr Pro Gly Gly Gln Gly Glu Ala Glu Arg Phe Met Xaa Pro 
            660                 665                 670         


Arg Val Arg Glu Glu Leu Leu Arg His Gln Leu Leu Glu Lys Arg Ser 
        675                 680                 685             


Met Gly Met Gln Arg Pro Leu Gly Met Ala Gly Ser Gly Met Gly Gln 
    690                 695                 700                 


Ser Met Glu Met Glu Arg Met Met Gln Ala His Arg Gln Met Asp Pro 
705                 710                 715                 720 


Ala Met Phe Pro Gly Gln Met Ala Gly Gly Glu Gly Leu Ala Gly Xaa 
                725                 730                 735     


Pro Met Gly Met Glu Phe Gly Gly Gly Arg Gly Leu Leu Ser Pro Pro 
            740                 745                 750         


Met Gly Gln Ser Gly Leu Arg Glu Val Asp Pro Pro Met Gly Pro Gly 
        755                 760                 765             


Asn Leu Asn Met Asn Met Asn Val Asn Met Asn Met Asn Met Asn Leu 
    770                 775                 780                 


Asn Val Gln Met Xaa Pro Gln Gln Gln Met Leu Met Ser Gln Lys Met 
785                 790                 795                 800 


Arg Gly Pro Gly Asp Leu Met Gly Pro Gln Gly Leu Ser Pro Glu Glu 
                805                 810                 815     


Met Ala Arg Val Arg Ala Gln Asn Ser Ser Gly Val Met Gly Gly Pro 
            820                 825                 830         


Gln Lys Met Leu Met Pro Ser Gln Phe Pro Asn Gln Gly Gln Gln Gly 
        835                 840                 845             


Phe Ser Gly Gly Gln Gly Pro Tyr Gln Ala Met Ser Gln Asp Met Gly 
    850                 855                 860                 


Asn Xaa Gln Asp Met Phe Ser Pro Asp Gln Ser Ser Met Pro Met Ser 
865                 870                 875                 880 


Asn Val Gly Xaa Xaa Arg Leu Ser His Met Pro Leu Pro Pro Ala Ser 
                885                 890                 895     


Asn Pro Pro Gly Xaa Val His Ser Ala Pro Asn Arg Gly Leu Gly Arg 
            900                 905                 910         


Arg Pro Ser Asp Leu Xaa Ile Ser Ile Asn Gln Met Gly Ser Pro Gly 
        915                 920                 925             


Met Gly His Leu Lys Ser Pro Xaa Leu Ser Gln Val His Ser Pro Leu 
    930                 935                 940                 


Val Xaa Ser Pro Ser Ala Asn Leu Lys Ser Pro Gln Xaa Pro Ser Gln 
945                 950                 955                 960 


Met Val Pro Leu Pro Ser Ala Asn Pro Pro Gly Pro Leu Lys Ser Pro 
                965                 970                 975     


Gln Val Leu Gly Ser Ser Leu Ser Val Arg Ser Pro Xaa Gly Ser Pro 
            980                 985                 990         


Ser Arg Leu Lys Ser Pro Ser Met  Ala Val Pro Ser Pro  Gly Trp Val 
        995                 1000                 1005             


Ala Ser  Pro Lys Xaa Ala Met  Pro Ser Pro Gly Val  Ser Gln Asn 
    1010                 1015                 1020             


Lys Gln  Pro Pro Leu Asn Met  Asn Ser Ser Xaa Xaa  Leu Ser Asn 
    1025                 1030                 1035             


Met Glu  Gln Gly Xaa Leu Pro  Pro Ser Gly Pro Arg  Ser Ser Ser 
    1040                 1045                 1050             


Ser Ala  Pro Pro Ala Asn Pro  Pro Ser Gly Leu Met  Asn Pro Ser 
    1055                 1060                 1065             


Leu Pro  Phe Xaa Ser Ser Pro  Asp Pro Xaa Pro Ser  Gln Asn Pro 
    1070                 1075                 1080             


Leu Ser  Leu Met Met Xaa Gln  Met Ser Lys Tyr Ala  Met Pro Ser 
    1085                 1090                 1095             


Ser Xaa  Pro Leu Tyr His Asn  Ala Ile Lys Xaa Ile  Ala Xaa Ser 
    1100                 1105                 1110             


Asp Asp  Glu Leu Leu Pro Asp  Arg Pro Leu Leu Pro  Pro Pro Pro 
    1115                 1120                 1125             


Pro Pro  Gln Gly Ser Gly Pro  Gly Ile Ser Asn Ser  Gln Pro Ser 
    1130                 1135                 1140             


Gln Met  His Leu Asn Ser Ala  Ala Ala Gln Ser Pro  Met Gly Met 
    1145                 1150                 1155             


Asn Leu  Pro Gly Gln Gln Pro  Leu Ser His Glu Pro  Pro Pro Ala 
    1160                 1165                 1170             


Met Leu  Pro Ser Pro Xaa Pro  Leu Gly Ser Asn Ile  Pro Leu His 
    1175                 1180                 1185             


Pro Asn  Ala Gln Gly Xaa Gly  Gly Pro Pro Gln Asn  Ser Met Met 
    1190                 1195                 1200             


Met Ala  Pro Gly Gly Pro Asp  Ser Leu Asn Ala Pro  Cys Gly Pro 
    1205                 1210                 1215             


Val Pro  Ser Ser Ser Gln Met  Met Pro Phe Pro Pro  Arg Leu Gln 
    1220                 1225                 1230             


Gln Pro  His Gly Ala Met Ala  Pro Xaa Gly Gly Gly  Gly Gly Gly 
    1235                 1240                 1245             


Pro Gly  Leu Gln Gln His Tyr  Pro Ser Gly Met Ala  Leu Pro Pro 
    1250                 1255                 1260             


Glu Asp  Leu Pro Asn Gln Pro  Pro Gly Pro Met Pro  Pro Gln Gln 
    1265                 1270                 1275             


His Leu  Met Gly Lys Ala Met  Ala Gly Arg Met Gly  Asp Ala Tyr 
    1280                 1285                 1290             


Pro Pro  Gly Val Leu Pro Gly  Val Ala Ser Val Leu  Asn Asp Pro 
    1295                 1300                 1305             


Glu Leu  Ser Glu Val Ile Arg  Pro Xaa Pro Xaa Gly  Ile Pro Glu 
    1310                 1315                 1320             


Phe Asp  Leu Ser Arg Ile Ile  Pro Ser Glu Lys Pro  Ser Ser Xaa 
    1325                 1330                 1335             


Leu Gln  Tyr Phe Pro Lys Ser  Glu Asn Gln Pro Pro  Lys Ala Gln 
    1340                 1345                 1350             


Pro Pro  Asn Leu His Leu Met  Asn Leu Gln Asn Met  Met Ala Glu 
    1355                 1360                 1365             


Gln Xaa  Pro Ser Arg Pro Pro  Asn Leu Pro Gly Gln  Gln Gly Val 
    1370                 1375                 1380             


Gln Arg  Gly Leu Asn Met Ser  Met Cys His Pro Gly  Gln Met Ser 
    1385                 1390                 1395             


Leu Leu  Gly Arg Xaa Gly Val  Pro Pro Gln Gln Gly  Met Val Pro 
    1400                 1405                 1410             


His Gly  Leu His Gln Gly Val  Met Ser Pro Pro Gln  Gly Leu Met 
    1415                 1420                 1425             


Xaa Gln  Gln Asn Phe Met Leu  Met Lys Gln Arg Gly  Val Gly Gly 
    1430                 1435                 1440             


Glu Val  Tyr Ser Gln Pro Pro  His Met Leu Ser Pro  Gln Gly Ser 
    1445                 1450                 1455             


Leu Met  Gly Pro Pro Pro Gln  Gln Asn Leu Met Val  Ser His Pro 
    1460                 1465                 1470             


Leu Arg  Gln Arg Ser Val Ser  Leu Asp Ser Gln Met  Gly Tyr Leu 
    1475                 1480                 1485             


Pro Ala  Pro Gly Gly Met Ala  Asn Leu Pro Phe 
    1490                 1495                 


<210> 4129
<211> 467
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<400> 4129
Met Gly Arg Ser Asn Ser Arg Ser His Ser Ser Arg Ser Lys Ser Arg 
1               5                   10                  15      


Ser Gln Ser Ser Ser Arg Ser Arg Ser Arg Ser His Ser Arg Lys Lys 
            20                  25                  30          


Arg Tyr Arg Ser Arg Ser Arg Xaa Tyr Ser Arg Ser Arg Ser Arg Asp 
        35                  40                  45              


Arg Met Tyr Ser Arg Asp Tyr Arg Arg Asp Tyr Arg Asn Asn Arg Gly 
    50                  55                  60                  


Met Arg Arg Pro Tyr Gly Tyr Arg Gly Arg Gly Arg Gly Tyr Tyr Gln 
65                  70                  75                  80  


Gly Gly Gly Gly Arg Tyr His Arg Gly Gly Tyr Arg Pro Val Trp Asn 
                85                  90                  95      


Arg Arg His Ser Arg Ser Pro Arg Arg Gly Arg Ser Arg Ser Arg Ser 
            100                 105                 110         


Pro Lys Arg Arg Ser Val Ser Ser Gln Arg Ser Arg Ser Arg Ser Arg 
        115                 120                 125             


Arg Ser Tyr Arg Ser Ser Arg Ser Pro Arg Ser Ser Ser Ser Arg Ser 
    130                 135                 140                 


Ser Ser Pro Tyr Ser Lys Ser Pro Val Ser Lys Arg Arg Gly Ser Gln 
145                 150                 155                 160 


Glu Lys Gln Xaa Lys Lys Ala Glu Gly Glu Pro Gln Glu Glu Ser Pro 
                165                 170                 175     


Leu Lys Ser Lys Ser Gln Glu Glu Pro Lys Asp Xaa Phe Glu His Asp 
            180                 185                 190         


Pro Ser Glu Ser Ile Asp Glu Phe Asn Lys Ser Ser Ala Xaa Ser Gly 
        195                 200                 205             


Asp Ile Trp Pro Gly Leu Ser Ala Tyr Asp Asn Ser Pro Arg Ser Pro 
    210                 215                 220                 


His Ser Pro Ser Pro Ile Ala Xaa Pro Pro Ser Gln Ser Ser Ser Cys 
225                 230                 235                 240 


Ser Asp Ala Pro Met Leu Ser Xaa Val His Ser Ala Lys Asn Xaa Pro 
                245                 250                 255     


Ser Gln His Ser His Ser Ile Gln His Ser Pro Glu Arg Ser Gly Ser 
            260                 265                 270         


Gly Ser Val Gly Asn Gly Ser Ser Arg Tyr Ser Pro Ser Gln Asn Ser 
        275                 280                 285             


Pro Ile His His Ile Pro Ser Arg Arg Ser Pro Ala Lys Xaa Ile Ala 
    290                 295                 300                 


Pro Gln Asn Ala Pro Arg Asp Glu Ser Arg Gly Arg Ser Ser Phe Tyr 
305                 310                 315                 320 


Pro Asp Gly Gly Asp Gln Glu Xaa Ala Lys Xaa Gly Lys Phe Leu Lys 
                325                 330                 335     


Ser Pro Pro Leu His Lys Asn Leu Asp Ala Arg Glu Lys Ser Xaa Phe 
            340                 345                 350         


Arg Glu Glu Ser Pro Leu Arg Ile Lys Met Ile Ala Ser Asp Ser His 
        355                 360                 365             


Arg Pro Glu Val Lys Leu Lys Met Ala Pro Val Pro Leu Asp Asp Ser 
    370                 375                 380                 


Asn Arg Pro Ala Ser Leu Xaa Lys Asp Arg Leu Leu Ala Ser Xaa Leu 
385                 390                 395                 400 


Val His Ser Val Lys Lys Glu Gln Glu Phe Arg Ser Ile Phe Asp His 
                405                 410                 415     


Ile Lys Leu Pro Gln Ala Ser Lys Ser Xaa Ser Glu Ser Phe Ile Gln 
            420                 425                 430         


His Ile Val Ser Leu Val His His Val Lys Gly Pro Gly Ile Cys Phe 
        435                 440                 445             


Glu Met Ala Lys Ser Met Phe Gln Ser Lys Ile Ala Val Glu Arg Tyr 
    450                 455                 460                 


Arg Gln Ser 
465         


<210> 4130
<211> 750
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<400> 4130
Met Gly Arg Ser Asn Ser Arg Ser His Ser Ser Arg Ser Lys Ser Arg 
1               5                   10                  15      


Ser Gln Ser Ser Ser Arg Ser Arg Ser Arg Ser His Ser Arg Lys Lys 
            20                  25                  30          


Arg Tyr Arg Ser Arg Ser Arg Xaa Tyr Ser Arg Ser Arg Ser Arg Asp 
        35                  40                  45              


Arg Met Tyr Ser Arg Asp Tyr Arg Arg Asp Tyr Arg Asn Asn Arg Gly 
    50                  55                  60                  


Met Arg Arg Pro Tyr Gly Tyr Arg Gly Arg Gly Arg Gly Tyr Tyr Gln 
65                  70                  75                  80  


Gly Gly Gly Gly Arg Tyr His Arg Gly Gly Tyr Arg Pro Val Trp Asn 
                85                  90                  95      


Arg Arg His Ser Arg Ser Pro Arg Arg Gly Arg Ser Arg Ser Arg Ser 
            100                 105                 110         


Pro Lys Arg Arg Ser Val Ser Ser Gln Arg Ser Arg Ser Arg Ser Arg 
        115                 120                 125             


Arg Ser Tyr Arg Ser Ser Arg Ser Pro Arg Ser Ser Ser Ser Arg Ser 
    130                 135                 140                 


Ser Ser Pro Tyr Ser Lys Ser Pro Val Ser Lys Arg Arg Gly Ser Gln 
145                 150                 155                 160 


Glu Lys Gln Xaa Lys Lys Ala Glu Gly Glu Pro Gln Glu Glu Ser Pro 
                165                 170                 175     


Leu Lys Ser Lys Ser Gln Glu Glu Pro Lys Asp Xaa Phe Glu His Asp 
            180                 185                 190         


Pro Ser Glu Ser Ile Asp Glu Phe Asn Lys Ser Ser Ala Xaa Ser Gly 
        195                 200                 205             


Asp Ile Trp Pro Gly Leu Ser Ala Tyr Asp Asn Ser Pro Arg Ser Pro 
    210                 215                 220                 


His Ser Pro Ser Pro Ile Ala Xaa Pro Pro Ser Gln Ser Ser Ser Cys 
225                 230                 235                 240 


Ser Asp Ala Pro Met Leu Ser Xaa Val His Ser Ala Lys Asn Xaa Pro 
                245                 250                 255     


Ser Gln His Ser His Ser Ile Gln His Ser Pro Glu Arg Ser Gly Ser 
            260                 265                 270         


Gly Ser Val Gly Asn Gly Ser Ser Arg Tyr Ser Pro Ser Gln Asn Ser 
        275                 280                 285             


Pro Ile His His Ile Pro Ser Arg Arg Ser Pro Ala Lys Xaa Ile Ala 
    290                 295                 300                 


Pro Gln Asn Ala Pro Arg Asp Glu Ser Arg Gly Arg Ser Ser Phe Tyr 
305                 310                 315                 320 


Pro Asp Gly Gly Asp Gln Glu Xaa Ala Lys Xaa Gly Lys Phe Leu Lys 
                325                 330                 335     


Arg Phe Xaa Asp Glu Glu Ser Arg Val Phe Leu Leu Asp Arg Gly Asn 
            340                 345                 350         


Xaa Arg Asp Lys Glu Ala Ser Lys Glu Lys Gly Ser Glu Lys Gly Arg 
        355                 360                 365             


Ala Glu Gly Glu Trp Glu Asp Gln Glu Ala Leu Asp Tyr Phe Ser Asp 
    370                 375                 380                 


Lys Glu Ser Gly Lys Gln Lys Phe Asn Asp Ser Glu Gly Asp Asp Xaa 
385                 390                 395                 400 


Glu Glu Xaa Glu Asp Tyr Arg Gln Phe Arg Lys Ser Val Leu Ala Asp 
                405                 410                 415     


Gln Gly Lys Ser Phe Ala Xaa Ala Ser His Arg Asn Xaa Glu Glu Glu 
            420                 425                 430         


Gly Leu Lys Tyr Lys Ser Lys Val Ser Leu Lys Gly Asn Arg Glu Ser 
        435                 440                 445             


Asp Gly Phe Arg Glu Glu Lys Asn Tyr Lys Leu Lys Glu Xaa Gly Tyr 
    450                 455                 460                 


Val Val Glu Arg Pro Ser Xaa Xaa Lys Asp Lys His Lys Glu Glu Asp 
465                 470                 475                 480 


Lys Asn Ser Glu Arg Ile Xaa Val Lys Lys Glu Xaa Gln Ser Pro Glu 
                485                 490                 495     


Gln Val Lys Ser Glu Lys Leu Lys Asp Leu Phe Asp Tyr Ser Pro Pro 
            500                 505                 510         


Leu His Lys Asn Leu Asp Ala Arg Glu Lys Ser Xaa Phe Arg Glu Glu 
        515                 520                 525             


Ser Pro Leu Arg Ile Lys Met Ile Ala Ser Asp Ser His Arg Pro Glu 
    530                 535                 540                 


Val Lys Leu Lys Met Ala Pro Val Pro Leu Asp Asp Ser Asn Arg Pro 
545                 550                 555                 560 


Ala Ser Leu Xaa Lys Asp Arg Leu Leu Ala Ser Xaa Leu Val His Ser 
                565                 570                 575     


Val Lys Lys Glu Gln Glu Phe Arg Ser Ile Phe Asp His Ile Lys Leu 
            580                 585                 590         


Pro Gln Ala Ser Lys Ser Xaa Ser Glu Ser Phe Ile Gln His Ile Val 
        595                 600                 605             


Ser Leu Val His His Val Lys Glu Gln Tyr Phe Lys Ser Ala Ala Met 
    610                 615                 620                 


Xaa Leu Asn Glu Arg Phe Xaa Ser Tyr Gln Lys Ala Xaa Glu Glu His 
625                 630                 635                 640 


Ser Xaa Arg Gln Lys Ser Pro Glu Ile His Arg Arg Ile Asp Ile Ser 
                645                 650                 655     


Pro Ser Xaa Leu Arg Lys His Xaa Arg Leu Ala Gly Glu Glu Arg Val 
            660                 665                 670         


Phe Lys Glu Glu Asn Gln Lys Gly Asp Lys Lys Leu Arg Cys Asp Ser 
        675                 680                 685             


Ala Asp Leu Arg His Asp Ile Asp Arg Arg Arg Lys Glu Arg Ser Lys 
    690                 695                 700                 


Glu Arg Gly Asp Ser Lys Gly Ser Arg Glu Ser Ser Gly Ser Arg Lys 
705                 710                 715                 720 


Gln Glu Lys Xaa Pro Lys Asp Tyr Lys Glu Tyr Lys Ser Tyr Lys Asp 
                725                 730                 735     


Asp Ser Lys Asn Val Phe Val Phe Tyr Xaa Ala Tyr Gly Gly 
            740                 745                 750 


<210> 4131
<211> 869
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<400> 4131
Met Gly Arg Ser Asn Ser Arg Ser His Ser Ser Arg Ser Lys Ser Arg 
1               5                   10                  15      


Ser Gln Ser Ser Ser Arg Ser Arg Ser Arg Ser His Ser Arg Lys Lys 
            20                  25                  30          


Arg Tyr Arg Ser Arg Ser Arg Xaa Tyr Ser Arg Ser Arg Ser Arg Asp 
        35                  40                  45              


Arg Met Tyr Ser Arg Asp Tyr Arg Arg Asp Tyr Arg Asn Asn Arg Gly 
    50                  55                  60                  


Met Arg Arg Pro Tyr Gly Tyr Arg Gly Arg Gly Arg Gly Tyr Tyr Gln 
65                  70                  75                  80  


Gly Gly Gly Gly Arg Tyr His Arg Gly Gly Tyr Arg Pro Val Trp Asn 
                85                  90                  95      


Arg Arg His Ser Arg Ser Pro Arg Arg Gly Arg Ser Arg Ser Arg Ser 
            100                 105                 110         


Pro Lys Arg Arg Ser Val Ser Ser Gln Arg Ser Arg Ser Arg Ser Arg 
        115                 120                 125             


Arg Ser Tyr Arg Ser Ser Arg Ser Pro Arg Ser Ser Ser Ser Arg Ser 
    130                 135                 140                 


Ser Ser Pro Tyr Ser Lys Ser Pro Val Ser Lys Arg Arg Gly Ser Gln 
145                 150                 155                 160 


Glu Lys Gln Xaa Lys Lys Ala Glu Gly Glu Pro Gln Glu Glu Ser Pro 
                165                 170                 175     


Leu Lys Ser Lys Ser Gln Glu Glu Pro Lys Asp Xaa Phe Glu His Asp 
            180                 185                 190         


Pro Ser Glu Ser Ile Asp Glu Phe Asn Lys Ser Ser Ala Xaa Ser Gly 
        195                 200                 205             


Asp Ile Trp Pro Gly Leu Ser Ala Tyr Asp Asn Ser Pro Arg Ser Pro 
    210                 215                 220                 


His Ser Pro Ser Pro Ile Ala Xaa Pro Pro Ser Gln Ser Ser Ser Cys 
225                 230                 235                 240 


Ser Asp Ala Pro Met Leu Ser Xaa Val His Ser Ala Lys Asn Xaa Pro 
                245                 250                 255     


Ser Gln His Ser His Ser Ile Gln His Ser Pro Glu Arg Ser Gly Ser 
            260                 265                 270         


Gly Ser Val Gly Asn Gly Ser Ser Arg Tyr Ser Pro Ser Gln Asn Ser 
        275                 280                 285             


Pro Ile His His Ile Pro Ser Arg Arg Ser Pro Ala Lys Xaa Ile Ala 
    290                 295                 300                 


Pro Gln Asn Ala Pro Arg Asp Glu Ser Arg Gly Arg Ser Ser Phe Tyr 
305                 310                 315                 320 


Pro Asp Gly Gly Asp Gln Glu Xaa Ala Lys Xaa Gly Lys Phe Leu Lys 
                325                 330                 335     


Arg Phe Xaa Asp Glu Glu Ser Arg Val Phe Leu Leu Asp Arg Gly Asn 
            340                 345                 350         


Xaa Arg Asp Lys Glu Ala Ser Lys Glu Lys Gly Ser Glu Lys Gly Arg 
        355                 360                 365             


Ala Glu Gly Glu Trp Glu Asp Gln Glu Ala Leu Asp Tyr Phe Ser Asp 
    370                 375                 380                 


Lys Glu Ser Gly Lys Gln Lys Phe Asn Asp Ser Glu Gly Asp Asp Xaa 
385                 390                 395                 400 


Glu Glu Xaa Glu Asp Tyr Arg Gln Phe Arg Lys Ser Val Leu Ala Asp 
                405                 410                 415     


Gln Gly Lys Ser Phe Ala Xaa Ala Ser His Arg Asn Xaa Glu Glu Glu 
            420                 425                 430         


Gly Leu Lys Tyr Lys Ser Lys Val Ser Leu Lys Gly Asn Arg Glu Ser 
        435                 440                 445             


Asp Gly Phe Arg Glu Glu Lys Asn Tyr Lys Leu Lys Glu Xaa Gly Tyr 
    450                 455                 460                 


Val Val Glu Arg Pro Ser Xaa Xaa Lys Asp Lys His Lys Glu Glu Asp 
465                 470                 475                 480 


Lys Asn Ser Glu Arg Ile Xaa Val Lys Lys Glu Xaa Gln Ser Pro Glu 
                485                 490                 495     


Gln Val Lys Ser Glu Lys Leu Lys Asp Leu Phe Asp Tyr Ser Pro Pro 
            500                 505                 510         


Leu His Lys Asn Leu Asp Ala Arg Glu Lys Ser Xaa Phe Arg Glu Glu 
        515                 520                 525             


Ser Pro Leu Arg Ile Lys Met Ile Ala Ser Asp Ser His Arg Pro Glu 
    530                 535                 540                 


Val Lys Leu Lys Met Ala Pro Val Pro Leu Asp Asp Ser Asn Arg Pro 
545                 550                 555                 560 


Ala Ser Leu Xaa Lys Asp Arg Leu Leu Ala Ser Xaa Leu Val His Ser 
                565                 570                 575     


Val Lys Lys Glu Gln Glu Phe Arg Ser Ile Phe Asp His Ile Lys Leu 
            580                 585                 590         


Pro Gln Ala Ser Lys Ser Xaa Ser Glu Ser Phe Ile Gln His Ile Val 
        595                 600                 605             


Ser Leu Val His His Val Lys Glu Gln Tyr Phe Lys Ser Ala Ala Met 
    610                 615                 620                 


Xaa Leu Asn Glu Arg Phe Xaa Ser Tyr Gln Lys Ala Xaa Glu Glu His 
625                 630                 635                 640 


Ser Xaa Arg Gln Lys Ser Pro Glu Ile His Arg Arg Ile Asp Ile Ser 
                645                 650                 655     


Pro Ser Xaa Leu Arg Lys His Xaa Arg Leu Ala Gly Glu Glu Arg Val 
            660                 665                 670         


Phe Lys Glu Glu Asn Gln Lys Gly Asp Lys Lys Leu Arg Cys Asp Ser 
        675                 680                 685             


Ala Asp Leu Arg His Asp Ile Asp Arg Arg Arg Lys Glu Arg Ser Lys 
    690                 695                 700                 


Glu Arg Gly Asp Ser Lys Gly Ser Arg Glu Ser Ser Gly Ser Arg Lys 
705                 710                 715                 720 


Gln Glu Lys Xaa Pro Lys Asp Tyr Lys Glu Tyr Lys Ser Tyr Lys Asp 
                725                 730                 735     


Asp Ser Lys His Lys Arg Glu Gln Asp His Ser Arg Ser Ser Ser Ser 
            740                 745                 750         


Ser Ala Ser Pro Ser Ser Pro Ser Ser Arg Glu Glu Lys Glu Ser Lys 
        755                 760                 765             


Lys Glu Arg Glu Glu Glu Phe Lys Xaa His His Glu Met Lys Glu Tyr 
    770                 775                 780                 


Ser Gly Phe Ala Gly Val Ser Arg Pro Arg Gly Xaa Phe His Asp Asp 
785                 790                 795                 800 


Arg Asp Asp Gly Val Asp Tyr Trp Ala Lys Arg Gly Arg Gly Arg Gly 
                805                 810                 815     


Xaa Phe Gln Arg Gly Arg Gly Arg Phe Asn Phe Lys Lys Ser Gly Ser 
            820                 825                 830         


Ser Pro Lys Trp Xaa His Asp Lys Tyr Gln Gly Asp Gly Ile Val Glu 
        835                 840                 845             


Asp Glu Glu Glu Xaa Met Glu Asn Asn Glu Glu Lys Lys Asp Arg Arg 
    850                 855                 860                 


Lys Glu Glu Lys Glu 
865                 


<210> 4132
<211> 918
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<400> 4132
Met Gly Arg Ser Asn Ser Arg Ser His Ser Ser Arg Ser Lys Ser Arg 
1               5                   10                  15      


Ser Gln Ser Ser Ser Arg Ser Arg Ser Arg Ser His Ser Arg Lys Lys 
            20                  25                  30          


Arg Tyr Arg Ser Arg Ser Arg Xaa Tyr Ser Arg Ser Arg Ser Arg Asp 
        35                  40                  45              


Arg Met Tyr Ser Arg Asp Tyr Arg Arg Asp Tyr Arg Asn Asn Arg Gly 
    50                  55                  60                  


Met Arg Arg Pro Tyr Gly Tyr Arg Gly Arg Gly Arg Gly Tyr Tyr Gln 
65                  70                  75                  80  


Gly Gly Gly Gly Arg Tyr His Arg Gly Gly Tyr Arg Pro Val Trp Asn 
                85                  90                  95      


Arg Arg His Ser Arg Ser Pro Arg Arg Gly Arg Ser Arg Ser Arg Ser 
            100                 105                 110         


Pro Lys Arg Arg Ser Val Ser Ser Gln Arg Ser Arg Ser Arg Ser Arg 
        115                 120                 125             


Arg Ser Tyr Arg Ser Ser Arg Ser Pro Arg Ser Ser Ser Ser Arg Ser 
    130                 135                 140                 


Ser Ser Pro Tyr Ser Lys Ser Pro Val Ser Lys Arg Arg Gly Ser Gln 
145                 150                 155                 160 


Glu Lys Gln Xaa Lys Lys Ala Glu Gly Glu Pro Gln Glu Glu Ser Pro 
                165                 170                 175     


Leu Lys Ser Lys Ser Gln Glu Glu Pro Lys Asp Xaa Phe Glu His Asp 
            180                 185                 190         


Pro Ser Glu Ser Ile Asp Glu Phe Asn Lys Ser Ser Ala Xaa Ser Gly 
        195                 200                 205             


Asp Ile Trp Pro Gly Leu Ser Ala Tyr Asp Asn Ser Pro Arg Ser Pro 
    210                 215                 220                 


His Ser Pro Ser Pro Ile Ala Xaa Pro Pro Ser Gln Ser Ser Ser Cys 
225                 230                 235                 240 


Ser Asp Ala Pro Met Leu Ser Xaa Val His Ser Ala Lys Asn Xaa Pro 
                245                 250                 255     


Ser Gln His Ser His Ser Ile Gln His Ser Pro Glu Arg Ser Gly Ser 
            260                 265                 270         


Gly Ser Val Gly Asn Gly Ser Ser Arg Tyr Ser Pro Ser Gln Asn Ser 
        275                 280                 285             


Pro Ile His His Ile Pro Ser Arg Arg Ser Pro Ala Lys Xaa Ile Ala 
    290                 295                 300                 


Pro Gln Asn Ala Pro Arg Asp Glu Ser Arg Gly Arg Ser Ser Phe Tyr 
305                 310                 315                 320 


Pro Asp Gly Gly Asp Gln Glu Xaa Ala Lys Xaa Gly Lys Phe Leu Lys 
                325                 330                 335     


Arg Phe Xaa Asp Glu Glu Ser Arg Val Phe Leu Leu Asp Arg Gly Asn 
            340                 345                 350         


Xaa Arg Asp Lys Glu Ala Ser Lys Glu Lys Gly Ser Glu Lys Gly Arg 
        355                 360                 365             


Ala Glu Gly Glu Trp Glu Asp Gln Glu Ala Leu Asp Tyr Phe Ser Asp 
    370                 375                 380                 


Lys Glu Ser Gly Lys Gln Lys Phe Asn Asp Ser Glu Gly Asp Asp Xaa 
385                 390                 395                 400 


Glu Glu Xaa Glu Asp Tyr Arg Gln Phe Arg Lys Ser Val Leu Ala Asp 
                405                 410                 415     


Gln Gly Lys Ser Phe Ala Xaa Ala Ser His Arg Asn Xaa Glu Glu Glu 
            420                 425                 430         


Gly Leu Lys Tyr Lys Ser Lys Val Ser Leu Lys Gly Asn Arg Glu Ser 
        435                 440                 445             


Asp Gly Phe Arg Glu Glu Lys Asn Tyr Lys Leu Lys Glu Xaa Gly Tyr 
    450                 455                 460                 


Val Val Glu Arg Pro Ser Xaa Xaa Lys Asp Lys His Lys Glu Glu Asp 
465                 470                 475                 480 


Lys Asn Ser Glu Arg Ile Xaa Val Lys Lys Glu Xaa Gln Ser Pro Glu 
                485                 490                 495     


Gln Val Lys Ser Glu Lys Leu Lys Asp Leu Phe Asp Tyr Ser Pro Pro 
            500                 505                 510         


Leu His Lys Asn Leu Asp Ala Arg Glu Lys Ser Xaa Phe Arg Glu Glu 
        515                 520                 525             


Ser Pro Leu Arg Ile Lys Met Ile Ala Ser Asp Ser His Arg Pro Glu 
    530                 535                 540                 


Val Lys Leu Lys Met Ala Pro Val Pro Leu Asp Asp Ser Asn Arg Pro 
545                 550                 555                 560 


Ala Ser Leu Xaa Lys Asp Arg Leu Leu Ala Ser Xaa Leu Val His Ser 
                565                 570                 575     


Val Lys Lys Glu Gln Glu Phe Arg Ser Ile Phe Asp His Ile Lys Leu 
            580                 585                 590         


Pro Gln Ala Ser Lys Ser Xaa Ser Glu Ser Phe Ile Gln His Ile Val 
        595                 600                 605             


Ser Leu Val His His Val Lys Glu Gln Tyr Phe Lys Ser Ala Ala Met 
    610                 615                 620                 


Xaa Leu Asn Glu Arg Phe Xaa Ser Tyr Gln Lys Ala Xaa Glu Glu His 
625                 630                 635                 640 


Ser Xaa Arg Gln Lys Ser Pro Glu Ile His Arg Arg Ile Asp Ile Ser 
                645                 650                 655     


Pro Ser Xaa Leu Arg Lys His Xaa Arg Leu Ala Gly Glu Glu Arg Val 
            660                 665                 670         


Phe Lys Glu Glu Asn Gln Lys Gly Asp Lys Lys Leu Arg Cys Asp Ser 
        675                 680                 685             


Ala Asp Leu Arg His Asp Ile Asp Arg Arg Arg Lys Glu Arg Ser Lys 
    690                 695                 700                 


Glu Arg Gly Asp Ser Lys Gly Ser Arg Glu Ser Ser Gly Ser Arg Lys 
705                 710                 715                 720 


Gln Glu Lys Xaa Pro Lys Asp Tyr Lys Glu Tyr Lys Ser Tyr Lys Asp 
                725                 730                 735     


Asp Ser Lys His Lys Arg Glu Gln Asp His Ser Arg Ser Ser Ser Ser 
            740                 745                 750         


Ser Ala Ser Pro Ser Ser Pro Ser Ser Arg Glu Glu Lys Glu Ser Lys 
        755                 760                 765             


Lys Glu Arg Glu Glu Glu Phe Lys Xaa His His Glu Met Lys Glu Tyr 
    770                 775                 780                 


Ser Gly Phe Ala Gly Val Ser Arg Pro Arg Gly Xaa Phe Phe Arg Ile 
785                 790                 795                 800 


Arg Gly Arg Gly Arg Ala Arg Gly Val Phe Ala Gly Xaa Asn Xaa Gly 
                805                 810                 815     


Pro Asn Asn Ser Asn Xaa Xaa Phe Gln Lys Arg Pro Lys Glu Glu Glu 
            820                 825                 830         


Trp Asp Pro Glu Tyr Xaa Pro Lys Ser Lys Lys Tyr Phe Leu His Asp 
        835                 840                 845             


Asp Arg Asp Asp Gly Val Asp Tyr Trp Ala Lys Arg Gly Arg Gly Arg 
    850                 855                 860                 


Gly Xaa Phe Gln Arg Gly Arg Gly Arg Phe Asn Phe Lys Lys Ser Gly 
865                 870                 875                 880 


Ser Ser Pro Lys Trp Xaa His Asp Lys Tyr Gln Gly Asp Gly Ile Val 
                885                 890                 895     


Glu Asp Glu Glu Glu Xaa Met Glu Asn Asn Glu Glu Lys Lys Asp Arg 
            900                 905                 910         


Arg Lys Glu Glu Lys Glu 
        915             


<210> 4133
<211> 726
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<400> 4133
Met Gly Arg Ser Asn Ser Arg Ser His Ser Ser Arg Ser Lys Ser Arg 
1               5                   10                  15      


Ser Gln Ser Ser Ser Arg Ser Arg Ser Arg Ser His Ser Arg Lys Lys 
            20                  25                  30          


Arg Tyr Ser Ser Arg Ser Arg Ser Arg Xaa Tyr Ser Arg Ser Arg Ser 
        35                  40                  45              


Arg Asp Arg Met Tyr Ser Arg Asp Tyr Arg Arg Asp Tyr Arg Asn Asn 
    50                  55                  60                  


Arg Gly Met Arg Arg Pro Tyr Gly Tyr Arg Gly Arg Gly Arg Gly Tyr 
65                  70                  75                  80  


Tyr Gln Gly Gly Gly Gly Arg Tyr His Arg Gly Gly Tyr Arg Pro Val 
                85                  90                  95      


Trp Asn Arg Arg His Ser Arg Ser Pro Arg Arg Gly Arg Ser Arg Ser 
            100                 105                 110         


Arg Ser Pro Lys Arg Arg Ser Val Ser Ser Gln Arg Ser Arg Ser Arg 
        115                 120                 125             


Ser Arg Arg Ser Tyr Arg Ser Ser Arg Ser Pro Arg Ser Ser Ser Ser 
    130                 135                 140                 


Arg Ser Ser Ser Pro Tyr Ser Lys Ser Pro Val Ser Lys Arg Arg Gly 
145                 150                 155                 160 


Ser Gln Glu Lys Gln Xaa Lys Lys Ala Glu Gly Glu Pro Gln Glu Glu 
                165                 170                 175     


Ser Pro Leu Lys Ser Lys Ser Gln Glu Glu Pro Lys Asp Xaa Phe Glu 
            180                 185                 190         


His Asp Pro Ser Glu Ser Ile Asp Glu Phe Asn Lys Ser Ser Ala Xaa 
        195                 200                 205             


Ser Gly Asp Ile Trp Pro Gly Leu Ser Ala Tyr Asp Asn Ser Pro Arg 
    210                 215                 220                 


Ser Pro His Ser Pro Ser Pro Ile Ala Xaa Pro Pro Ser Gln Ser Ser 
225                 230                 235                 240 


Ser Cys Ser Asp Ala Pro Met Leu Ser Xaa Val His Ser Ala Lys Asn 
                245                 250                 255     


Xaa Pro Ser Gln His Ser His Ser Ile Gln His Ser Pro Glu Arg Ser 
            260                 265                 270         


Gly Ser Gly Ser Val Gly Asn Gly Ser Ser Arg Tyr Ser Pro Ser Gln 
        275                 280                 285             


Asn Ser Pro Ile His His Ile Pro Ser Arg Arg Ser Pro Ala Lys Xaa 
    290                 295                 300                 


Ile Ala Pro Gln Asn Ala Pro Arg Asp Glu Ser Arg Gly Arg Ser Ser 
305                 310                 315                 320 


Phe Tyr Pro Asp Gly Gly Asp Gln Glu Xaa Ala Lys Xaa Gly Lys Phe 
                325                 330                 335     


Leu Lys Arg Phe Xaa Asp Glu Glu Ser Arg Val Phe Leu Leu Asp Arg 
            340                 345                 350         


Gly Asn Xaa Arg Asp Lys Glu Ala Ser Lys Glu Lys Gly Ser Glu Lys 
        355                 360                 365             


Gly Arg Ala Glu Gly Glu Trp Glu Asp Gln Glu Ala Leu Asp Tyr Phe 
    370                 375                 380                 


Ser Asp Lys Glu Ser Gly Lys Gln Lys Phe Asn Asp Ser Glu Gly Asp 
385                 390                 395                 400 


Asp Xaa Glu Glu Xaa Glu Asp Tyr Arg Gln Phe Arg Lys Ser Val Leu 
                405                 410                 415     


Ala Asp Gln Gly Lys Ser Phe Ala Xaa Ala Ser His Arg Asn Xaa Glu 
            420                 425                 430         


Glu Glu Gly Leu Lys Tyr Lys Ser Lys Val Ser Leu Lys Gly Asn Arg 
        435                 440                 445             


Glu Ser Asp Gly Phe Arg Glu Glu Lys Asn Tyr Lys Leu Lys Glu Xaa 
    450                 455                 460                 


Gly Tyr Val Val Glu Arg Pro Ser Xaa Xaa Lys Asp Lys His Lys Glu 
465                 470                 475                 480 


Glu Asp Lys Asn Ser Glu Arg Ile Xaa Val Lys Lys Glu Xaa Gln Ser 
                485                 490                 495     


Pro Glu Gln Val Lys Ser Glu Lys Leu Lys Asp Leu Phe Asp Tyr Ser 
            500                 505                 510         


Pro Pro Leu His Lys Asn Leu Asp Ala Arg Glu Lys Ser Xaa Phe Arg 
        515                 520                 525             


Glu Glu Ser Pro Leu Arg Ile Lys Met Ile Ala Ser Asp Ser His Arg 
    530                 535                 540                 


Pro Glu Val Lys Leu Lys Met Ala Pro Val Pro Leu Asp Asp Ser Asn 
545                 550                 555                 560 


Arg Pro Ala Ser Leu Xaa Lys Asp Arg Leu Leu Ala Ser Xaa Leu Val 
                565                 570                 575     


His Ser Val Lys Lys Glu Gln Glu Phe Arg Ser Ile Phe Asp His Ile 
            580                 585                 590         


Lys Leu Pro Gln Ala Ser Lys Ser Xaa Ser Glu Ser Phe Ile Gln His 
        595                 600                 605             


Ile Val Ser Leu Val His His Val Lys Glu Gln Tyr Phe Lys Ser Ala 
    610                 615                 620                 


Ala Met Xaa Leu Asn Glu Arg Phe Xaa Ser Tyr Gln Lys Ala Xaa Glu 
625                 630                 635                 640 


Glu His Ser Xaa Arg Gln Lys Ser Pro Glu Ile His Arg Ile Asp Ile 
                645                 650                 655     


Ser Pro Ser Xaa Leu Arg Lys His Xaa Arg Leu Ala Gly Glu Glu Arg 
            660                 665                 670         


Val Phe Lys Glu Glu Asn Gln Lys Gly Asp Lys Lys Leu Arg Cys Asp 
        675                 680                 685             


Ser Ala Asp Leu Arg His Asp Ile Asp Arg Arg Arg Lys Glu Arg Ser 
    690                 695                 700                 


Lys Glu Arg Gly Asp Ser Lys Gly Ser Arg Glu Ser Ser Gly Ser Arg 
705                 710                 715                 720 


Lys Gln Glu Lys Xaa Pro 
                725     


<210> 4134
<211> 747
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<400> 4134
Met Gly Arg Ser Asn Ser Arg Ser His Ser Ser Arg Ser Lys Ser Arg 
1               5                   10                  15      


Ser Gln Ser Ser Ser Arg Ser Arg Ser Arg Ser His Ser Arg Lys Lys 
            20                  25                  30          


Arg Tyr Ser Ser Arg Ser Arg Ser Arg Xaa Tyr Ser Arg Ser Arg Ser 
        35                  40                  45              


Arg Asp Arg Met Tyr Ser Arg Asp Tyr Arg Arg Asp Tyr Arg Asn Asn 
    50                  55                  60                  


Arg Gly Met Arg Arg Pro Tyr Gly Tyr Arg Gly Arg Gly Arg Gly Tyr 
65                  70                  75                  80  


Tyr Gln Gly Gly Gly Gly Arg Tyr His Arg Gly Gly Tyr Arg Pro Val 
                85                  90                  95      


Trp Asn Arg Arg His Ser Arg Ser Pro Arg Arg Gly Arg Ser Arg Ser 
            100                 105                 110         


Arg Ser Pro Lys Arg Arg Ser Val Ser Ser Gln Arg Ser Arg Ser Arg 
        115                 120                 125             


Ser Arg Arg Ser Tyr Arg Ser Ser Arg Ser Pro Arg Ser Ser Ser Ser 
    130                 135                 140                 


Arg Ser Ser Ser Pro Tyr Ser Lys Ser Pro Val Ser Lys Arg Arg Gly 
145                 150                 155                 160 


Ser Gln Glu Lys Gln Xaa Lys Lys Ala Glu Gly Glu Pro Gln Glu Glu 
                165                 170                 175     


Ser Pro Leu Lys Ser Lys Ser Gln Glu Glu Pro Lys Asp Xaa Phe Glu 
            180                 185                 190         


His Asp Pro Ser Glu Ser Ile Asp Glu Phe Asn Lys Ser Ser Ala Xaa 
        195                 200                 205             


Ser Gly Asp Ile Trp Pro Gly Leu Ser Ala Tyr Asp Asn Ser Pro Arg 
    210                 215                 220                 


Ser Pro His Ser Pro Ser Pro Ile Ala Xaa Pro Pro Ser Gln Ser Ser 
225                 230                 235                 240 


Ser Cys Ser Asp Ala Pro Met Leu Ser Xaa Val His Ser Ala Lys Asn 
                245                 250                 255     


Xaa Pro Ser Gln His Ser His Ser Ile Gln His Ser Pro Glu Arg Ser 
            260                 265                 270         


Gly Ser Gly Ser Val Gly Asn Gly Ser Ser Arg Tyr Ser Pro Ser Gln 
        275                 280                 285             


Asn Ser Pro Ile His His Ile Pro Ser Arg Arg Ser Pro Ala Lys Xaa 
    290                 295                 300                 


Ile Ala Pro Gln Asn Ala Pro Arg Asp Glu Ser Arg Gly Arg Ser Ser 
305                 310                 315                 320 


Phe Tyr Pro Asp Gly Gly Asp Gln Glu Xaa Ala Lys Xaa Gly Lys Phe 
                325                 330                 335     


Leu Lys Ser Pro Pro Leu His Lys Asn Leu Asp Ala Arg Glu Lys Ser 
            340                 345                 350         


Xaa Phe Arg Glu Glu Ser Pro Leu Arg Ile Lys Met Ile Ala Ser Asp 
        355                 360                 365             


Ser His Arg Pro Glu Val Lys Leu Lys Met Ala Pro Val Pro Leu Asp 
    370                 375                 380                 


Asp Ser Asn Arg Pro Ala Ser Leu Xaa Lys Asp Arg Leu Leu Ala Ser 
385                 390                 395                 400 


Xaa Leu Val His Ser Val Lys Lys Glu Gln Glu Phe Arg Ser Ile Phe 
                405                 410                 415     


Asp His Ile Lys Leu Pro Gln Ala Ser Lys Ser Xaa Ser Glu Ser Phe 
            420                 425                 430         


Ile Gln His Ile Val Ser Leu Val His His Val Lys Glu Gln Tyr Phe 
        435                 440                 445             


Lys Ser Ala Ala Met Xaa Leu Asn Glu Arg Phe Xaa Ser Tyr Gln Lys 
    450                 455                 460                 


Ala Xaa Glu Glu His Ser Xaa Arg Gln Lys Ser Pro Glu Ile His Arg 
465                 470                 475                 480 


Arg Ile Asp Ile Ser Pro Ser Xaa Leu Arg Lys His Xaa Arg Leu Ala 
                485                 490                 495     


Gly Glu Glu Arg Val Phe Lys Glu Glu Asn Gln Lys Gly Asp Lys Lys 
            500                 505                 510         


Leu Arg Cys Asp Ser Ala Asp Leu Arg His Asp Ile Asp Arg Arg Arg 
        515                 520                 525             


Lys Glu Arg Ser Lys Glu Arg Gly Asp Ser Lys Gly Ser Arg Glu Ser 
    530                 535                 540                 


Ser Gly Ser Arg Lys Gln Glu Lys Xaa Pro Lys Asp Tyr Lys Glu Tyr 
545                 550                 555                 560 


Lys Ser Tyr Lys Asp Asp Ser Lys His Lys Arg Glu Gln Asp His Ser 
                565                 570                 575     


Arg Ser Ser Ser Ser Ser Ala Ser Pro Ser Ser Pro Ser Ser Arg Glu 
            580                 585                 590         


Glu Lys Glu Ser Lys Lys Glu Arg Glu Glu Glu Phe Lys Xaa His His 
        595                 600                 605             


Glu Met Lys Glu Tyr Ser Gly Phe Ala Gly Val Ser Arg Pro Arg Gly 
    610                 615                 620                 


Xaa Phe Phe Arg Ile Arg Gly Arg Gly Arg Ala Arg Gly Val Phe Ala 
625                 630                 635                 640 


Gly Xaa Asn Xaa Gly Pro Asn Asn Ser Asn Xaa Xaa Phe Gln Lys Arg 
                645                 650                 655     


Pro Lys Glu Glu Glu Trp Asp Pro Glu Tyr Xaa Pro Lys Ser Lys Lys 
            660                 665                 670         


Tyr Phe Leu His Asp Asp Arg Asp Asp Gly Val Asp Tyr Trp Ala Lys 
        675                 680                 685             


Arg Gly Arg Gly Arg Gly Xaa Phe Gln Arg Gly Arg Gly Arg Phe Asn 
    690                 695                 700                 


Phe Lys Lys Ser Gly Ser Ser Pro Lys Trp Xaa His Asp Lys Tyr Gln 
705                 710                 715                 720 


Gly Asp Gly Ile Val Glu Asp Glu Glu Glu Xaa Met Glu Asn Asn Glu 
                725                 730                 735     


Glu Lys Lys Asp Arg Arg Lys Glu Glu Lys Glu 
            740                 745         


<210> 4135
<211> 752
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<400> 4135
Met Gly Arg Ser Asn Ser Arg Ser His Ser Ser Arg Ser Lys Ser Arg 
1               5                   10                  15      


Ser Gln Ser Ser Ser Arg Ser Arg Ser Arg Ser His Ser Arg Lys Lys 
            20                  25                  30          


Arg Tyr Ser Ser Arg Ser Arg Ser Arg Xaa Tyr Ser Arg Ser Arg Ser 
        35                  40                  45              


Arg Asp Arg Met Tyr Ser Arg Asp Tyr Arg Arg Asp Tyr Arg Asn Asn 
    50                  55                  60                  


Arg Gly Met Arg Arg Pro Tyr Gly Tyr Arg Gly Arg Gly Arg Gly Tyr 
65                  70                  75                  80  


Tyr Gln Gly Gly Gly Gly Arg Tyr His Arg Gly Gly Tyr Arg Pro Val 
                85                  90                  95      


Trp Asn Arg Arg His Ser Arg Ser Pro Arg Arg Gly Arg Ser Arg Ser 
            100                 105                 110         


Arg Ser Pro Lys Arg Arg Ser Val Ser Ser Gln Arg Ser Arg Ser Arg 
        115                 120                 125             


Ser Arg Arg Ser Tyr Arg Ser Ser Arg Ser Pro Arg Ser Ser Ser Ser 
    130                 135                 140                 


Arg Ser Ser Ser Pro Tyr Ser Lys Ser Pro Val Ser Lys Arg Arg Gly 
145                 150                 155                 160 


Ser Gln Glu Lys Gln Xaa Lys Lys Ala Glu Gly Glu Pro Gln Glu Glu 
                165                 170                 175     


Ser Pro Leu Lys Ser Lys Ser Gln Glu Glu Pro Lys Asp Xaa Phe Glu 
            180                 185                 190         


His Asp Pro Ser Glu Ser Ile Asp Glu Phe Asn Lys Ser Ser Ala Xaa 
        195                 200                 205             


Ser Gly Asp Ile Trp Pro Gly Leu Ser Ala Tyr Asp Asn Ser Pro Arg 
    210                 215                 220                 


Ser Pro His Ser Pro Ser Pro Ile Ala Xaa Pro Pro Ser Gln Ser Ser 
225                 230                 235                 240 


Ser Cys Ser Asp Ala Pro Met Leu Ser Xaa Val His Ser Ala Lys Asn 
                245                 250                 255     


Xaa Pro Ser Gln His Ser His Ser Ile Gln His Ser Pro Glu Arg Ser 
            260                 265                 270         


Gly Ser Gly Ser Val Gly Asn Gly Ser Ser Arg Tyr Ser Pro Ser Gln 
        275                 280                 285             


Asn Ser Pro Ile His His Ile Pro Ser Arg Arg Ser Pro Ala Lys Xaa 
    290                 295                 300                 


Ile Ala Pro Gln Asn Ala Pro Arg Asp Glu Ser Arg Gly Arg Ser Ser 
305                 310                 315                 320 


Phe Tyr Pro Asp Gly Gly Asp Gln Glu Xaa Ala Lys Xaa Gly Lys Phe 
                325                 330                 335     


Leu Lys Arg Phe Xaa Asp Glu Glu Ser Arg Val Phe Leu Leu Asp Arg 
            340                 345                 350         


Gly Asn Xaa Arg Asp Lys Glu Ala Ser Lys Glu Lys Gly Ser Glu Lys 
        355                 360                 365             


Gly Arg Ala Glu Gly Glu Trp Glu Asp Gln Glu Ala Leu Asp Tyr Phe 
    370                 375                 380                 


Ser Asp Lys Glu Ser Gly Lys Gln Lys Phe Asn Asp Ser Glu Gly Asp 
385                 390                 395                 400 


Asp Xaa Glu Glu Xaa Glu Asp Tyr Arg Gln Phe Arg Lys Ser Val Leu 
                405                 410                 415     


Ala Asp Gln Gly Lys Ser Phe Ala Xaa Ala Ser His Arg Asn Xaa Glu 
            420                 425                 430         


Glu Glu Gly Leu Lys Tyr Lys Ser Lys Val Ser Leu Lys Gly Asn Arg 
        435                 440                 445             


Glu Ser Asp Gly Phe Arg Glu Glu Lys Asn Tyr Lys Leu Lys Glu Xaa 
    450                 455                 460                 


Gly Tyr Val Val Glu Arg Pro Ser Xaa Xaa Lys Asp Lys His Lys Glu 
465                 470                 475                 480 


Glu Asp Lys Asn Ser Glu Arg Ile Xaa Val Lys Lys Glu Xaa Gln Ser 
                485                 490                 495     


Pro Glu Gln Val Lys Ser Glu Lys Leu Lys Asp Leu Phe Asp Tyr Ser 
            500                 505                 510         


Pro Pro Leu His Lys Asn Leu Asp Ala Arg Glu Lys Ser Xaa Phe Arg 
        515                 520                 525             


Glu Glu Ser Pro Leu Arg Ile Lys Met Ile Ala Ser Asp Ser His Arg 
    530                 535                 540                 


Pro Glu Val Lys Leu Lys Met Ala Pro Val Pro Leu Asp Asp Ser Asn 
545                 550                 555                 560 


Arg Pro Ala Ser Leu Xaa Lys Asp Arg Leu Leu Ala Ser Xaa Leu Val 
                565                 570                 575     


His Ser Val Lys Lys Glu Gln Glu Phe Arg Ser Ile Phe Asp His Ile 
            580                 585                 590         


Lys Leu Pro Gln Ala Ser Lys Ser Xaa Ser Glu Ser Phe Ile Gln His 
        595                 600                 605             


Ile Val Ser Leu Val His His Val Lys Glu Gln Tyr Phe Lys Ser Ala 
    610                 615                 620                 


Ala Met Xaa Leu Asn Glu Arg Phe Xaa Ser Tyr Gln Lys Ala Xaa Glu 
625                 630                 635                 640 


Glu His Ser Xaa Arg Gln Lys Ser Pro Glu Ile His Arg Arg Ile Asp 
                645                 650                 655     


Ile Ser Pro Ser Xaa Leu Arg Lys His Xaa Arg Leu Ala Gly Glu Glu 
            660                 665                 670         


Arg Val Phe Lys Glu Glu Asn Gln Lys Gly Asp Lys Lys Leu Arg Cys 
        675                 680                 685             


Asp Ser Ala Asp Leu Arg His Asp Ile Asp Arg Arg Arg Lys Glu Arg 
    690                 695                 700                 


Ser Lys Glu Arg Gly Asp Ser Lys Gly Ser Arg Glu Ser Ser Gly Ser 
705                 710                 715                 720 


Arg Lys Gln Glu Lys Xaa Pro Lys Asp Tyr Lys Glu Tyr Lys Ser Tyr 
                725                 730                 735     


Lys Asp Asp Ser Lys Asn Val Phe Val Phe Tyr Xaa Ala Tyr Gly Gly 
            740                 745                 750         


<210> 4136
<211> 871
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<400> 4136
Met Gly Arg Ser Asn Ser Arg Ser His Ser Ser Arg Ser Lys Ser Arg 
1               5                   10                  15      


Ser Gln Ser Ser Ser Arg Ser Arg Ser Arg Ser His Ser Arg Lys Lys 
            20                  25                  30          


Arg Tyr Ser Ser Arg Ser Arg Ser Arg Xaa Tyr Ser Arg Ser Arg Ser 
        35                  40                  45              


Arg Asp Arg Met Tyr Ser Arg Asp Tyr Arg Arg Asp Tyr Arg Asn Asn 
    50                  55                  60                  


Arg Gly Met Arg Arg Pro Tyr Gly Tyr Arg Gly Arg Gly Arg Gly Tyr 
65                  70                  75                  80  


Tyr Gln Gly Gly Gly Gly Arg Tyr His Arg Gly Gly Tyr Arg Pro Val 
                85                  90                  95      


Trp Asn Arg Arg His Ser Arg Ser Pro Arg Arg Gly Arg Ser Arg Ser 
            100                 105                 110         


Arg Ser Pro Lys Arg Arg Ser Val Ser Ser Gln Arg Ser Arg Ser Arg 
        115                 120                 125             


Ser Arg Arg Ser Tyr Arg Ser Ser Arg Ser Pro Arg Ser Ser Ser Ser 
    130                 135                 140                 


Arg Ser Ser Ser Pro Tyr Ser Lys Ser Pro Val Ser Lys Arg Arg Gly 
145                 150                 155                 160 


Ser Gln Glu Lys Gln Xaa Lys Lys Ala Glu Gly Glu Pro Gln Glu Glu 
                165                 170                 175     


Ser Pro Leu Lys Ser Lys Ser Gln Glu Glu Pro Lys Asp Xaa Phe Glu 
            180                 185                 190         


His Asp Pro Ser Glu Ser Ile Asp Glu Phe Asn Lys Ser Ser Ala Xaa 
        195                 200                 205             


Ser Gly Asp Ile Trp Pro Gly Leu Ser Ala Tyr Asp Asn Ser Pro Arg 
    210                 215                 220                 


Ser Pro His Ser Pro Ser Pro Ile Ala Xaa Pro Pro Ser Gln Ser Ser 
225                 230                 235                 240 


Ser Cys Ser Asp Ala Pro Met Leu Ser Xaa Val His Ser Ala Lys Asn 
                245                 250                 255     


Xaa Pro Ser Gln His Ser His Ser Ile Gln His Ser Pro Glu Arg Ser 
            260                 265                 270         


Gly Ser Gly Ser Val Gly Asn Gly Ser Ser Arg Tyr Ser Pro Ser Gln 
        275                 280                 285             


Asn Ser Pro Ile His His Ile Pro Ser Arg Arg Ser Pro Ala Lys Xaa 
    290                 295                 300                 


Ile Ala Pro Gln Asn Ala Pro Arg Asp Glu Ser Arg Gly Arg Ser Ser 
305                 310                 315                 320 


Phe Tyr Pro Asp Gly Gly Asp Gln Glu Xaa Ala Lys Xaa Gly Lys Phe 
                325                 330                 335     


Leu Lys Arg Phe Xaa Asp Glu Glu Ser Arg Val Phe Leu Leu Asp Arg 
            340                 345                 350         


Gly Asn Xaa Arg Asp Lys Glu Ala Ser Lys Glu Lys Gly Ser Glu Lys 
        355                 360                 365             


Gly Arg Ala Glu Gly Glu Trp Glu Asp Gln Glu Ala Leu Asp Tyr Phe 
    370                 375                 380                 


Ser Asp Lys Glu Ser Gly Lys Gln Lys Phe Asn Asp Ser Glu Gly Asp 
385                 390                 395                 400 


Asp Xaa Glu Glu Xaa Glu Asp Tyr Arg Gln Phe Arg Lys Ser Val Leu 
                405                 410                 415     


Ala Asp Gln Gly Lys Ser Phe Ala Xaa Ala Ser His Arg Asn Xaa Glu 
            420                 425                 430         


Glu Glu Gly Leu Lys Tyr Lys Ser Lys Val Ser Leu Lys Gly Asn Arg 
        435                 440                 445             


Glu Ser Asp Gly Phe Arg Glu Glu Lys Asn Tyr Lys Leu Lys Glu Xaa 
    450                 455                 460                 


Gly Tyr Val Val Glu Arg Pro Ser Xaa Xaa Lys Asp Lys His Lys Glu 
465                 470                 475                 480 


Glu Asp Lys Asn Ser Glu Arg Ile Xaa Val Lys Lys Glu Xaa Gln Ser 
                485                 490                 495     


Pro Glu Gln Val Lys Ser Glu Lys Leu Lys Asp Leu Phe Asp Tyr Ser 
            500                 505                 510         


Pro Pro Leu His Lys Asn Leu Asp Ala Arg Glu Lys Ser Xaa Phe Arg 
        515                 520                 525             


Glu Glu Ser Pro Leu Arg Ile Lys Met Ile Ala Ser Asp Ser His Arg 
    530                 535                 540                 


Pro Glu Val Lys Leu Lys Met Ala Pro Val Pro Leu Asp Asp Ser Asn 
545                 550                 555                 560 


Arg Pro Ala Ser Leu Xaa Lys Asp Arg Leu Leu Ala Ser Xaa Leu Val 
                565                 570                 575     


His Ser Val Lys Lys Glu Gln Glu Phe Arg Ser Ile Phe Asp His Ile 
            580                 585                 590         


Lys Leu Pro Gln Ala Ser Lys Ser Xaa Ser Glu Ser Phe Ile Gln His 
        595                 600                 605             


Ile Val Ser Leu Val His His Val Lys Glu Gln Tyr Phe Lys Ser Ala 
    610                 615                 620                 


Ala Met Xaa Leu Asn Glu Arg Phe Xaa Ser Tyr Gln Lys Ala Xaa Glu 
625                 630                 635                 640 


Glu His Ser Xaa Arg Gln Lys Ser Pro Glu Ile His Arg Arg Ile Asp 
                645                 650                 655     


Ile Ser Pro Ser Xaa Leu Arg Lys His Xaa Arg Leu Ala Gly Glu Glu 
            660                 665                 670         


Arg Val Phe Lys Glu Glu Asn Gln Lys Gly Asp Lys Lys Leu Arg Cys 
        675                 680                 685             


Asp Ser Ala Asp Leu Arg His Asp Ile Asp Arg Arg Arg Lys Glu Arg 
    690                 695                 700                 


Ser Lys Glu Arg Gly Asp Ser Lys Gly Ser Arg Glu Ser Ser Gly Ser 
705                 710                 715                 720 


Arg Lys Gln Glu Lys Xaa Pro Lys Asp Tyr Lys Glu Tyr Lys Ser Tyr 
                725                 730                 735     


Lys Asp Asp Ser Lys His Lys Arg Glu Gln Asp His Ser Arg Ser Ser 
            740                 745                 750         


Ser Ser Ser Ala Ser Pro Ser Ser Pro Ser Ser Arg Glu Glu Lys Glu 
        755                 760                 765             


Ser Lys Lys Glu Arg Glu Glu Glu Phe Lys Xaa His His Glu Met Lys 
    770                 775                 780                 


Glu Tyr Ser Gly Phe Ala Gly Val Ser Arg Pro Arg Gly Xaa Phe His 
785                 790                 795                 800 


Asp Asp Arg Asp Asp Gly Val Asp Tyr Trp Ala Lys Arg Gly Arg Gly 
                805                 810                 815     


Arg Gly Xaa Phe Gln Arg Gly Arg Gly Arg Phe Asn Phe Lys Lys Ser 
            820                 825                 830         


Gly Ser Ser Pro Lys Trp Xaa His Asp Lys Tyr Gln Gly Asp Gly Ile 
        835                 840                 845             


Val Glu Asp Glu Glu Glu Xaa Met Glu Asn Asn Glu Glu Lys Lys Asp 
    850                 855                 860                 


Arg Arg Lys Glu Glu Lys Glu 
865                 870     


<210> 4137
<211> 920
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<400> 4137
Met Gly Arg Ser Asn Ser Arg Ser His Ser Ser Arg Ser Lys Ser Arg 
1               5                   10                  15      


Ser Gln Ser Ser Ser Arg Ser Arg Ser Arg Ser His Ser Arg Lys Lys 
            20                  25                  30          


Arg Tyr Ser Ser Arg Ser Arg Ser Arg Xaa Tyr Ser Arg Ser Arg Ser 
        35                  40                  45              


Arg Asp Arg Met Tyr Ser Arg Asp Tyr Arg Arg Asp Tyr Arg Asn Asn 
    50                  55                  60                  


Arg Gly Met Arg Arg Pro Tyr Gly Tyr Arg Gly Arg Gly Arg Gly Tyr 
65                  70                  75                  80  


Tyr Gln Gly Gly Gly Gly Arg Tyr His Arg Gly Gly Tyr Arg Pro Val 
                85                  90                  95      


Trp Asn Arg Arg His Ser Arg Ser Pro Arg Arg Gly Arg Ser Arg Ser 
            100                 105                 110         


Arg Ser Pro Lys Arg Arg Ser Val Ser Ser Gln Arg Ser Arg Ser Arg 
        115                 120                 125             


Ser Arg Arg Ser Tyr Arg Ser Ser Arg Ser Pro Arg Ser Ser Ser Ser 
    130                 135                 140                 


Arg Ser Ser Ser Pro Tyr Ser Lys Ser Pro Val Ser Lys Arg Arg Gly 
145                 150                 155                 160 


Ser Gln Glu Lys Gln Xaa Lys Lys Ala Glu Gly Glu Pro Gln Glu Glu 
                165                 170                 175     


Ser Pro Leu Lys Ser Lys Ser Gln Glu Glu Pro Lys Asp Xaa Phe Glu 
            180                 185                 190         


His Asp Pro Ser Glu Ser Ile Asp Glu Phe Asn Lys Ser Ser Ala Xaa 
        195                 200                 205             


Ser Gly Asp Ile Trp Pro Gly Leu Ser Ala Tyr Asp Asn Ser Pro Arg 
    210                 215                 220                 


Ser Pro His Ser Pro Ser Pro Ile Ala Xaa Pro Pro Ser Gln Ser Ser 
225                 230                 235                 240 


Ser Cys Ser Asp Ala Pro Met Leu Ser Xaa Val His Ser Ala Lys Asn 
                245                 250                 255     


Xaa Pro Ser Gln His Ser His Ser Ile Gln His Ser Pro Glu Arg Ser 
            260                 265                 270         


Gly Ser Gly Ser Val Gly Asn Gly Ser Ser Arg Tyr Ser Pro Ser Gln 
        275                 280                 285             


Asn Ser Pro Ile His His Ile Pro Ser Arg Arg Ser Pro Ala Lys Xaa 
    290                 295                 300                 


Ile Ala Pro Gln Asn Ala Pro Arg Asp Glu Ser Arg Gly Arg Ser Ser 
305                 310                 315                 320 


Phe Tyr Pro Asp Gly Gly Asp Gln Glu Xaa Ala Lys Xaa Gly Lys Phe 
                325                 330                 335     


Leu Lys Arg Phe Xaa Asp Glu Glu Ser Arg Val Phe Leu Leu Asp Arg 
            340                 345                 350         


Gly Asn Xaa Arg Asp Lys Glu Ala Ser Lys Glu Lys Gly Ser Glu Lys 
        355                 360                 365             


Gly Arg Ala Glu Gly Glu Trp Glu Asp Gln Glu Ala Leu Asp Tyr Phe 
    370                 375                 380                 


Ser Asp Lys Glu Ser Gly Lys Gln Lys Phe Asn Asp Ser Glu Gly Asp 
385                 390                 395                 400 


Asp Xaa Glu Glu Xaa Glu Asp Tyr Arg Gln Phe Arg Lys Ser Val Leu 
                405                 410                 415     


Ala Asp Gln Gly Lys Ser Phe Ala Xaa Ala Ser His Arg Asn Xaa Glu 
            420                 425                 430         


Glu Glu Gly Leu Lys Tyr Lys Ser Lys Val Ser Leu Lys Gly Asn Arg 
        435                 440                 445             


Glu Ser Asp Gly Phe Arg Glu Glu Lys Asn Tyr Lys Leu Lys Glu Xaa 
    450                 455                 460                 


Gly Tyr Val Val Glu Arg Pro Ser Xaa Xaa Lys Asp Lys His Lys Glu 
465                 470                 475                 480 


Glu Asp Lys Asn Ser Glu Arg Ile Xaa Val Lys Lys Glu Xaa Gln Ser 
                485                 490                 495     


Pro Glu Gln Val Lys Ser Glu Lys Leu Lys Asp Leu Phe Asp Tyr Ser 
            500                 505                 510         


Pro Pro Leu His Lys Asn Leu Asp Ala Arg Glu Lys Ser Xaa Phe Arg 
        515                 520                 525             


Glu Glu Ser Pro Leu Arg Ile Lys Met Ile Ala Ser Asp Ser His Arg 
    530                 535                 540                 


Pro Glu Val Lys Leu Lys Met Ala Pro Val Pro Leu Asp Asp Ser Asn 
545                 550                 555                 560 


Arg Pro Ala Ser Leu Xaa Lys Asp Arg Leu Leu Ala Ser Xaa Leu Val 
                565                 570                 575     


His Ser Val Lys Lys Glu Gln Glu Phe Arg Ser Ile Phe Asp His Ile 
            580                 585                 590         


Lys Leu Pro Gln Ala Ser Lys Ser Xaa Ser Glu Ser Phe Ile Gln His 
        595                 600                 605             


Ile Val Ser Leu Val His His Val Lys Glu Gln Tyr Phe Lys Ser Ala 
    610                 615                 620                 


Ala Met Xaa Leu Asn Glu Arg Phe Xaa Ser Tyr Gln Lys Ala Xaa Glu 
625                 630                 635                 640 


Glu His Ser Xaa Arg Gln Lys Ser Pro Glu Ile His Arg Arg Ile Asp 
                645                 650                 655     


Ile Ser Pro Ser Xaa Leu Arg Lys His Xaa Arg Leu Ala Gly Glu Glu 
            660                 665                 670         


Arg Val Phe Lys Glu Glu Asn Gln Lys Gly Asp Lys Lys Leu Arg Cys 
        675                 680                 685             


Asp Ser Ala Asp Leu Arg His Asp Ile Asp Arg Arg Arg Lys Glu Arg 
    690                 695                 700                 


Ser Lys Glu Arg Gly Asp Ser Lys Gly Ser Arg Glu Ser Ser Gly Ser 
705                 710                 715                 720 


Arg Lys Gln Glu Lys Xaa Pro Lys Asp Tyr Lys Glu Tyr Lys Ser Tyr 
                725                 730                 735     


Lys Asp Asp Ser Lys His Lys Arg Glu Gln Asp His Ser Arg Ser Ser 
            740                 745                 750         


Ser Ser Ser Ala Ser Pro Ser Ser Pro Ser Ser Arg Glu Glu Lys Glu 
        755                 760                 765             


Ser Lys Lys Glu Arg Glu Glu Glu Phe Lys Xaa His His Glu Met Lys 
    770                 775                 780                 


Glu Tyr Ser Gly Phe Ala Gly Val Ser Arg Pro Arg Gly Xaa Phe Phe 
785                 790                 795                 800 


Arg Ile Arg Gly Arg Gly Arg Ala Arg Gly Val Phe Ala Gly Xaa Asn 
                805                 810                 815     


Xaa Gly Pro Asn Asn Ser Asn Xaa Xaa Phe Gln Lys Arg Pro Lys Glu 
            820                 825                 830         


Glu Glu Trp Asp Pro Glu Tyr Xaa Pro Lys Ser Lys Lys Tyr Phe Leu 
        835                 840                 845             


His Asp Asp Arg Asp Asp Gly Val Asp Tyr Trp Ala Lys Arg Gly Arg 
    850                 855                 860                 


Gly Arg Gly Xaa Phe Gln Arg Gly Arg Gly Arg Phe Asn Phe Lys Lys 
865                 870                 875                 880 


Ser Gly Ser Ser Pro Lys Trp Xaa His Asp Lys Tyr Gln Gly Asp Gly 
                885                 890                 895     


Ile Val Glu Asp Glu Glu Glu Xaa Met Glu Asn Asn Glu Glu Lys Lys 
            900                 905                 910         


Asp Arg Arg Lys Glu Glu Lys Glu 
        915                 920 


<210> 4138
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 4138
Gln His Ser His Ser Ile Gln His Ser Pro Glu Arg Ser Gly Ser Gly 
1               5                   10                  15      


Ser Val Gly Asn Gly Ser Ser Arg Tyr Ser Pro Ser Gln Asn Ser Pro 
            20                  25                  30          


Ile His His Ile Pro Ser Arg Arg Ser Pro Ala Lys Xaa Ile Ala Pro 
        35                  40                  45              


Gln Asn Ala Pro Arg Asp Glu Ser Arg Gly Arg Ser Ser Phe Tyr Pro 
    50                  55                  60                  


Asp Gly Gly Asp Gln Glu Xaa Ala Lys Xaa Gly Lys Phe Leu Lys Arg 
65                  70                  75                  80  


Phe Xaa Asp Glu Glu Ser Arg Val Phe Leu Leu Asp Arg Val Pro Leu 
                85                  90                  95      


Tyr Xaa Arg Ile Trp Met His Glu Lys Ser Leu Pro Ser Glu Arg Lys 
            100                 105                 110         


Ala His Leu Gly Ser Lys 
        115             


<210> 4139
<211> 126
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 4139
Xaa Asp His Ser Arg Ser Ser Ser Ser Ser Ala Ser Pro Ser Ser Pro 
1               5                   10                  15      


Ser Ser Arg Glu Glu Lys Glu Ser Lys Lys Glu Arg Glu Glu Glu Phe 
            20                  25                  30          


Lys Xaa His His Glu Met Lys Glu Tyr Ser Gly Phe Ala Gly Val Ser 
        35                  40                  45              


Arg Pro Arg Gly Xaa Phe His Asp Asp Arg Asp Asp Gly Val Asp Tyr 
    50                  55                  60                  


Trp Ala Lys Arg Gly Arg Gly Arg Gly Xaa Phe Gln Arg Gly Arg Gly 
65                  70                  75                  80  


Arg Phe Asn Phe Lys Lys Ser Gly Ser Ser Pro Lys Trp Xaa His Asp 
                85                  90                  95      


Lys Tyr Gln Gly Asp Gly Ile Val Glu Asp Glu Glu Glu Xaa Met Glu 
            100                 105                 110         


Asn Asn Glu Glu Lys Lys Asp Arg Arg Lys Glu Glu Lys Glu 
        115                 120                 125     


<210> 4140
<211> 187
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<400> 4140
Xaa Gly Ser Arg Glu Ser Ser Gly Ser Arg Lys Gln Glu Lys Xaa Pro 
1               5                   10                  15      


Lys Asp Tyr Lys Glu Tyr Lys Ser Tyr Lys Asp Asp Ser Ser Arg Glu 
            20                  25                  30          


Glu Lys Glu Ser Lys Lys Glu Arg Glu Glu Glu Phe Lys Xaa His His 
        35                  40                  45              


Glu Met Lys Glu Tyr Ser Gly Phe Ala Gly Val Ser Arg Pro Arg Gly 
    50                  55                  60                  


Xaa Phe Phe Arg Ile Arg Gly Arg Gly Arg Ala Arg Gly Val Phe Ala 
65                  70                  75                  80  


Gly Xaa Asn Xaa Gly Pro Asn Asn Ser Asn Xaa Xaa Phe Gln Lys Arg 
                85                  90                  95      


Pro Lys Glu Glu Glu Trp Asp Pro Glu Tyr Xaa Pro Lys Ser Lys Lys 
            100                 105                 110         


Tyr Phe Leu His Asp Asp Arg Asp Asp Gly Val Asp Tyr Trp Ala Lys 
        115                 120                 125             


Arg Gly Arg Gly Arg Gly Xaa Phe Gln Arg Gly Arg Gly Arg Phe Asn 
    130                 135                 140                 


Phe Lys Lys Ser Gly Ser Ser Pro Lys Trp Xaa His Asp Lys Tyr Gln 
145                 150                 155                 160 


Gly Asp Gly Ile Val Glu Asp Glu Glu Glu Xaa Met Glu Asn Asn Glu 
                165                 170                 175     


Glu Lys Lys Asp Arg Arg Lys Glu Glu Lys Glu 
            180                 185         


<210> 4141
<211> 257
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<400> 4141
Ala Leu Glu Ser Xaa Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
1               5                   10                  15      


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Xaa 
            20                  25                  30          


Tyr Leu Ser His Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys 
        35                  40                  45              


Ala Ala Ala Xaa Xaa Ser Gln Pro Val Leu Xaa Ser Gln Gln Ile Glu 
    50                  55                  60                  


Xaa Ile Phe Phe Lys Val Pro Glu Leu Tyr Glu Ile His Lys Glu Phe 
65                  70                  75                  80  


Tyr Asp Gly Leu Phe Pro Arg Val Gln Gln Trp Ser His Gln Gln Arg 
                85                  90                  95      


Val Gly Asp Leu Phe Gln Lys Leu Asn Leu Arg Ala Arg Ser Asn Lys 
            100                 105                 110         


Asp Ala Lys Asp Pro Xaa Xaa Lys Asn Ser Leu Glu Xaa Leu Leu Tyr 
        115                 120                 125             


Lys Pro Val Asp Arg Val Xaa Arg Ser Xaa Leu Val Leu His Asp Leu 
    130                 135                 140                 


Leu Lys His Xaa Pro Ala Ser His Pro Asp His Pro Leu Leu Gln Asp 
145                 150                 155                 160 


Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile Asn Glu Glu Ile 
                165                 170                 175     


Xaa Pro Arg Arg Gln Ser Met Xaa Val Lys Lys Gly Glu His Arg Gln 
            180                 185                 190         


Leu Leu Lys Asp Ser Phe Met Val Glu Leu Val Glu Gly Ala Arg Lys 
        195                 200                 205             


Leu Arg His Val Phe Leu Phe Xaa Asp Leu Leu Leu Cys Xaa Lys Leu 
    210                 215                 220                 


Lys Lys Gln Ser Gly Gly Lys Xaa Gln Gln Tyr Asp Cys Lys Trp Tyr 
225                 230                 235                 240 


Ile Pro Leu Xaa Asp Leu Ser Phe Gln Met Val Asp Glu Leu Glu Ala 
                245                 250                 255     


Val 
    


<210> 4142
<211> 465
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<400> 4142
Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Xaa Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Xaa Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Xaa Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Xaa Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Xaa Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Xaa Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Xaa Xaa Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Xaa Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Xaa Ile Val Gly Val Arg Lys Xaa Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Glu His Pro Gly Ala Ala Glu Glu 
            420                 425                 430         


Val Phe Gln Lys Leu Leu Pro Asp Ile Arg Gly Ala Ala Asp Ala Asp 
        435                 440                 445             


Gln Leu Val Cys Glu Xaa Pro Asp Cys Pro Gln His Ser Ala Asp His 
    450                 455                 460                 


Gln 
465 


<210> 4143
<211> 1227
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1083)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1161)..(1161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1225)
<223> Selenocysteine

<400> 4143
Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Xaa Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Xaa Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Xaa Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Xaa Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Xaa Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Xaa Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Xaa Xaa Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Xaa Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Xaa Ile Val Gly Val Arg Lys Xaa Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Xaa 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Glu Ser Xaa Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Xaa 
            500                 505                 510         


Tyr Leu Ser His Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys 
        515                 520                 525             


Ala Ala Ala Xaa Xaa Ser Gln Pro Val Leu Xaa Ser Gln Gln Ile Glu 
    530                 535                 540                 


Xaa Ile Phe Phe Lys Val Pro Glu Leu Tyr Glu Ile His Lys Glu Phe 
545                 550                 555                 560 


Tyr Asp Gly Leu Phe Pro Arg Val Gln Gln Trp Ser His Gln Gln Arg 
                565                 570                 575     


Val Gly Asp Leu Phe Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Arg 
            580                 585                 590         


Ala Phe Val Asp Asn Tyr Gly Val Ala Met Glu Met Ala Glu Lys Cys 
        595                 600                 605             


Cys Gln Ala Asn Ala Gln Phe Ala Glu Ile Ser Glu Asn Leu Arg Ala 
    610                 615                 620                 


Arg Ser Asn Lys Asp Ala Lys Asp Pro Xaa Xaa Lys Asn Ser Leu Glu 
625                 630                 635                 640 


Xaa Leu Leu Tyr Lys Pro Val Asp Arg Val Xaa Arg Ser Xaa Leu Val 
                645                 650                 655     


Leu His Asp Leu Leu Lys His Xaa Pro Ala Ser His Pro Asp His Pro 
            660                 665                 670         


Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile 
        675                 680                 685             


Asn Glu Glu Ile Xaa Pro Arg Arg Gln Ser Met Xaa Val Lys Lys Gly 
    690                 695                 700                 


Glu His Arg Gln Leu Leu Lys Asp Ser Phe Met Val Glu Leu Val Glu 
705                 710                 715                 720 


Gly Ala Arg Lys Leu Arg His Val Phe Leu Phe Xaa Asp Leu Leu Leu 
                725                 730                 735     


Cys Xaa Lys Leu Lys Lys Gln Ser Gly Gly Lys Xaa Gln Gln Tyr Asp 
            740                 745                 750         


Cys Lys Trp Tyr Ile Pro Leu Xaa Asp Leu Ser Phe Gln Met Val Asp 
        755                 760                 765             


Glu Leu Glu Ala Val Pro Asn Ile Pro Leu Val Pro Asp Glu Glu Leu 
    770                 775                 780                 


Asp Ala Leu Lys Ile Lys Ile Ser Gln Ile Lys Asn Asp Ile Gln Arg 
785                 790                 795                 800 


Glu Lys Arg Ala Asn Lys Gly Ser Lys Ala Xaa Glu Arg Leu Lys Lys 
                805                 810                 815     


Lys Leu Ser Glu Gln Glu Ser Leu Leu Leu Leu Met Ser Pro Ser Met 
            820                 825                 830         


Ala Phe Arg Val His Ser Arg Asn Gly Lys Ser Tyr Xaa Phe Leu Ile 
        835                 840                 845             


Ser Ser Asp Tyr Glu Arg Ala Glu Trp Arg Glu Asn Ile Arg Glu Gln 
    850                 855                 860                 


Gln Lys Lys Cys Phe Arg Ser Phe Ser Leu Xaa Ser Val Glu Leu Gln 
865                 870                 875                 880 


Met Leu Xaa Asn Ser Cys Val Lys Leu Gln Xaa Val His Ser Ile Pro 
                885                 890                 895     


Leu Xaa Ile Asn Lys Glu Asp Asp Glu Ser Pro Gly Leu Tyr Gly Phe 
            900                 905                 910         


Leu Asn Val Ile Val His Ser Ala Xaa Gly Phe Lys Gln Ser Ser Asn 
        915                 920                 925             


Leu Tyr Cys Xaa Leu Glu Val Asp Ser Phe Gly Tyr Phe Val Asn Lys 
    930                 935                 940                 


Ala Lys Xaa Arg Val Tyr Arg Asp Xaa Ala Glu Pro Asn Trp Asn Glu 
945                 950                 955                 960 


Leu Asp Pro Gln Ala Leu Gln Asp Arg Asp Trp Gln Arg Xaa Val Ile 
                965                 970                 975     


Ala Met Asn Gly Ile Glu Val Lys Leu Ser Val Lys Phe Asn Ser Arg 
            980                 985                 990         


Glu Phe Ser Leu Lys Arg Met Pro  Ser Arg Lys Gln Xaa  Gly Val Phe 
        995                 1000                 1005             


Gly Val  Lys Ile Ala Val Val  Xaa Lys Arg Glu Arg  Ser Lys Val 
    1010                 1015                 1020             


Pro Tyr  Ile Val Arg Gln Cys  Val Glu Glu Ile Glu  Arg Arg Gly 
    1025                 1030                 1035             


Met Glu  Glu Val Gly Ile Tyr  Arg Val Ser Gly Val  Ala Xaa Asp 
    1040                 1045                 1050             


Ile Gln  Ala Leu Lys Ala Ala  Phe Asp Val Asn Asn  Lys Asp Val 
    1055                 1060                 1065             


Ser Val  Met Met Ser Glu Met  Asp Val Asn Ala Ile  Ala Gly Xaa 
    1070                 1075                 1080             


Leu Lys  Leu Tyr Phe Arg Glu  Leu Pro Glu Pro Leu  Phe Xaa Asp 
    1085                 1090                 1095             


Glu Phe  Tyr Pro Asn Phe Ala  Glu Gly Ile Ala Leu  Ser Asp Pro 
    1100                 1105                 1110             


Val Ala  Lys Glu Ser Cys Met  Leu Asn Leu Leu Leu  Ser Leu Pro 
    1115                 1120                 1125             


Glu Ala  Asn Leu Leu Xaa Phe  Leu Phe Leu Leu Asp  His Leu Lys 
    1130                 1135                 1140             


Arg Val  Ala Glu Lys Glu Ala  Val Asn Lys Met Ser  Leu His Asn 
    1145                 1150                 1155             


Leu Ala  Xaa Val Phe Gly Pro  Xaa Leu Leu Arg Pro  Ser Glu Lys 
    1160                 1165                 1170             


Glu Ser  Lys Leu Pro Ala Asn  Pro Ser Gln Pro Ile  Xaa Met Xaa 
    1175                 1180                 1185             


Asp Ser  Trp Ser Leu Glu Val  Met Ser Gln Val Gln  Val Leu Leu 
    1190                 1195                 1200             


Tyr Phe  Leu Gln Leu Glu Ala  Ile Pro Ala Pro Asp  Ser Lys Arg 
    1205                 1210                 1215             


Gln Ser  Ile Leu Phe Ser Xaa  Glu Val 
    1220                 1225         


<210> 4144
<211> 1271
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<400> 4144
Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Xaa Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Xaa Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Xaa Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Xaa Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Xaa Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Xaa Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Xaa Xaa Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Xaa Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Xaa Ile Val Gly Val Arg Lys Xaa Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Xaa 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Glu Ser Xaa Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Xaa 
            500                 505                 510         


Tyr Leu Ser His Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys 
        515                 520                 525             


Ala Ala Ala Xaa Xaa Ser Gln Pro Val Leu Xaa Ser Gln Gln Ile Glu 
    530                 535                 540                 


Xaa Ile Phe Phe Lys Val Pro Glu Leu Tyr Glu Ile His Lys Glu Phe 
545                 550                 555                 560 


Tyr Asp Gly Leu Phe Pro Arg Val Gln Gln Trp Ser His Gln Gln Arg 
                565                 570                 575     


Val Gly Asp Leu Phe Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Arg 
            580                 585                 590         


Ala Phe Val Asp Asn Tyr Gly Val Ala Met Glu Met Ala Glu Lys Cys 
        595                 600                 605             


Cys Gln Ala Asn Ala Gln Phe Ala Glu Ile Ser Glu Asn Leu Arg Ala 
    610                 615                 620                 


Arg Ser Asn Lys Asp Ala Lys Asp Pro Xaa Xaa Lys Asn Ser Leu Glu 
625                 630                 635                 640 


Xaa Leu Leu Tyr Lys Pro Val Asp Arg Val Xaa Arg Ser Xaa Leu Val 
                645                 650                 655     


Leu His Asp Leu Leu Lys His Xaa Pro Ala Ser His Pro Asp His Pro 
            660                 665                 670         


Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile 
        675                 680                 685             


Asn Glu Glu Ile Xaa Pro Arg Arg Gln Ser Met Xaa Val Lys Lys Gly 
    690                 695                 700                 


Glu His Arg Gln Leu Leu Lys Asp Ser Phe Met Val Glu Leu Val Glu 
705                 710                 715                 720 


Gly Ala Arg Lys Leu Arg His Val Phe Leu Phe Xaa Asp Leu Leu Leu 
                725                 730                 735     


Cys Xaa Lys Leu Lys Lys Gln Ser Gly Gly Lys Xaa Gln Gln Tyr Asp 
            740                 745                 750         


Cys Lys Trp Tyr Ile Pro Leu Xaa Asp Leu Ser Phe Gln Met Val Asp 
        755                 760                 765             


Glu Leu Glu Ala Val Pro Asn Ile Pro Leu Val Pro Asp Glu Glu Leu 
    770                 775                 780                 


Asp Ala Leu Lys Ile Lys Ile Ser Gln Ile Lys Asn Asp Ile Gln Arg 
785                 790                 795                 800 


Glu Lys Arg Ala Asn Lys Gly Ser Lys Ala Xaa Glu Arg Leu Lys Lys 
                805                 810                 815     


Lys Leu Ser Glu Gln Glu Ser Leu Leu Leu Leu Met Ser Pro Ser Met 
            820                 825                 830         


Ala Phe Arg Val His Ser Arg Asn Gly Lys Ser Tyr Xaa Phe Leu Ile 
        835                 840                 845             


Ser Ser Asp Tyr Glu Arg Ala Glu Trp Arg Glu Asn Ile Arg Glu Gln 
    850                 855                 860                 


Gln Lys Lys Cys Phe Arg Ser Phe Ser Leu Xaa Ser Val Glu Leu Gln 
865                 870                 875                 880 


Met Leu Xaa Asn Ser Cys Val Lys Leu Gln Xaa Val His Ser Ile Pro 
                885                 890                 895     


Leu Xaa Ile Asn Lys Glu Asp Asp Glu Ser Pro Gly Leu Tyr Gly Phe 
            900                 905                 910         


Leu Asn Val Ile Val His Ser Ala Xaa Gly Phe Lys Gln Ser Ser Asn 
        915                 920                 925             


Leu Tyr Cys Xaa Leu Glu Val Asp Ser Phe Gly Tyr Phe Val Asn Lys 
    930                 935                 940                 


Ala Lys Xaa Arg Val Tyr Arg Asp Xaa Ala Glu Pro Asn Trp Asn Glu 
945                 950                 955                 960 


Glu Phe Glu Ile Glu Leu Glu Gly Ser Gln Xaa Leu Arg Ile Leu Cys 
                965                 970                 975     


Tyr Glu Lys Cys Tyr Asn Lys Xaa Lys Ile Pro Lys Glu Asp Gly Glu 
            980                 985                 990         


Ser Xaa Asp Arg Leu Met Gly Lys  Gly Gln Val Gln Leu  Asp Pro Gln 
        995                 1000                 1005             


Ala Leu  Gln Asp Arg Asp Trp  Gln Arg Xaa Val Ile  Ala Met Asn 
    1010                 1015                 1020             


Gly Ile  Glu Val Lys Leu Ser  Val Lys Phe Asn Ser  Arg Glu Phe 
    1025                 1030                 1035             


Ser Leu  Lys Arg Met Pro Ser  Arg Lys Gln Xaa Gly  Val Phe Gly 
    1040                 1045                 1050             


Val Lys  Ile Ala Val Val Xaa  Lys Arg Glu Arg Ser  Lys Val Pro 
    1055                 1060                 1065             


Tyr Ile  Val Arg Gln Cys Val  Glu Glu Ile Glu Arg  Arg Gly Met 
    1070                 1075                 1080             


Glu Glu  Val Gly Ile Tyr Arg  Val Ser Gly Val Ala  Xaa Asp Ile 
    1085                 1090                 1095             


Gln Ala  Leu Lys Ala Ala Phe  Asp Val Asn Asn Lys  Asp Val Ser 
    1100                 1105                 1110             


Val Met  Met Ser Glu Met Asp  Val Asn Ala Ile Ala  Gly Xaa Leu 
    1115                 1120                 1125             


Lys Leu  Tyr Phe Arg Glu Leu  Pro Glu Pro Leu Phe  Xaa Asp Glu 
    1130                 1135                 1140             


Phe Tyr  Pro Asn Phe Ala Glu  Gly Ile Ala Leu Ser  Asp Pro Val 
    1145                 1150                 1155             


Ala Lys  Glu Ser Cys Met Leu  Asn Leu Leu Leu Ser  Leu Pro Glu 
    1160                 1165                 1170             


Ala Asn  Leu Leu Xaa Phe Leu  Phe Leu Leu Asp His  Leu Lys Arg 
    1175                 1180                 1185             


Val Ala  Glu Lys Glu Ala Val  Asn Lys Met Ser Leu  His Asn Leu 
    1190                 1195                 1200             


Ala Xaa  Val Phe Gly Pro Xaa  Leu Leu Arg Pro Ser  Glu Lys Glu 
    1205                 1210                 1215             


Ser Lys  Leu Pro Ala Asn Pro  Ser Gln Pro Ile Xaa  Met Xaa Asp 
    1220                 1225                 1230             


Ser Trp  Ser Leu Glu Val Met  Ser Gln Val Gln Val  Leu Leu Tyr 
    1235                 1240                 1245             


Phe Leu  Gln Leu Glu Ala Ile  Pro Ala Pro Asp Ser  Lys Arg Gln 
    1250                 1255                 1260             


Ser Ile  Leu Phe Ser Xaa Glu  Val 
    1265                 1270     


<210> 4145
<211> 353
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<400> 4145
Met Ala Ser Ser Trp Pro Pro Leu Glu Leu Gln Ser Ser Asn Gln Ser 
1               5                   10                  15      


Gln Leu Phe Pro Gln Asn Ala Xaa Ala Cys Asp Asn Ala Pro Glu Ala 
            20                  25                  30          


Trp Asp Leu Leu His Arg Val Leu Pro Xaa Phe Ile Ile Ser Ile Cys 
        35                  40                  45              


Phe Phe Gly Leu Leu Gly Asn Leu Phe Val Leu Leu Val Phe Leu Leu 
    50                  55                  60                  


Pro Arg Arg Gln Leu Asn Val Ala Glu Ile Tyr Leu Ala Asn Leu Ala 
65                  70                  75                  80  


Ala Ser Asp Leu Val Phe Val Leu Gly Leu Pro Phe Trp Ala Glu Asn 
                85                  90                  95      


Ile Trp Asn Gln Phe Asn Trp Pro Phe Gly Ala Leu Leu Cys Arg Val 
            100                 105                 110         


Ile Asn Gly Val Ile Lys Ala Asn Leu Phe Ile Ser Ile Phe Leu Val 
        115                 120                 125             


Val Ala Ile Ser Gln Asp Arg Tyr Arg Val Leu Val His Pro Met Ala 
    130                 135                 140                 


Ser Arg Arg Gln Gln Arg Arg Arg Gln Ala Arg Val Xaa Cys Val Leu 
145                 150                 155                 160 


Ile Trp Val Val Gly Gly Leu Leu Ser Ile Pro Xaa Phe Leu Leu Arg 
                165                 170                 175     


Ser Ile Gln Ala Val Pro Asp Leu Asn Ile Xaa Ala Cys Ile Leu Leu 
            180                 185                 190         


Leu Pro His Glu Ala Trp His Phe Ala Arg Ile Val Glu Leu Asn Ile 
        195                 200                 205             


Leu Gly Phe Leu Leu Pro Leu Ala Ala Ile Val Phe Phe Asn Tyr His 
    210                 215                 220                 


Ile Leu Ala Ser Leu Arg Xaa Arg Glu Glu Val Ser Arg Xaa Arg Cys 
225                 230                 235                 240 


Gly Gly Arg Lys Asp Ser Lys Xaa Xaa Ala Leu Ile Leu Xaa Leu Val 
                245                 250                 255     


Val Ala Phe Leu Val Cys Trp Ala Pro Tyr His Phe Phe Ala Phe Leu 
            260                 265                 270         


Glu Phe Leu Phe Gln Val Gln Ala Val Arg Gly Cys Phe Trp Glu Asp 
        275                 280                 285             


Phe Ile Asp Leu Gly Leu Gln Leu Ala Asn Phe Phe Ala Phe Xaa Asn 
    290                 295                 300                 


Ser Ser Leu Asn Pro Val Ile Tyr Val Phe Val Gly Arg Leu Phe Arg 
305                 310                 315                 320 


Xaa Lys Val Trp Glu Leu Tyr Lys Gln Cys Xaa Pro Lys Ser Leu Ala 
                325                 330                 335     


Pro Ile Ser Ser Ser His Arg Lys Glu Ile Phe Gln Leu Phe Trp Arg 
            340                 345                 350         


Asn 
    


<210> 4146
<211> 284
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<400> 4146
Met Ala Ser Ser Trp Pro Pro Leu Glu Leu Gln Ser Ser Asn Gln Ser 
1               5                   10                  15      


Gln Leu Phe Pro Gln Asn Ala Xaa Ala Cys Asp Asn Ala Pro Glu Ala 
            20                  25                  30          


Trp Asp Leu Leu His Arg Val Leu Pro Xaa Phe Ile Ile Ser Ile Cys 
        35                  40                  45              


Phe Phe Gly Leu Leu Gly Asn Leu Phe Val Leu Leu Val Phe Leu Leu 
    50                  55                  60                  


Pro Arg Arg Gln Leu Asn Val Ala Glu Ile Tyr Leu Ala Asn Leu Ala 
65                  70                  75                  80  


Ala Ser Asp Leu Val Phe Val Leu Gly Leu Pro Phe Trp Ala Glu Asn 
                85                  90                  95      


Ile Trp Asn Gln Phe Asn Trp Pro Phe Gly Ala Leu Leu Cys Arg Val 
            100                 105                 110         


Ile Asn Gly Val Ile Lys Ala Asn Leu Phe Ile Ser Ile Phe Leu Val 
        115                 120                 125             


Val Ala Ile Ser Gln Asp Arg Tyr Arg Val Leu Val His Pro Met Ala 
    130                 135                 140                 


Ser Arg Arg Gln Gln Arg Arg Arg Gln Ala Arg Val Xaa Cys Val Leu 
145                 150                 155                 160 


Ile Trp Val Val Gly Gly Leu Leu Ser Ile Pro Xaa Phe Leu Leu Arg 
                165                 170                 175     


Ser Ile Gln Ala Val Pro Asp Leu Asn Ile Xaa Ala Cys Ile Leu Leu 
            180                 185                 190         


Leu Pro His Glu Ala Trp His Phe Ala Arg Ile Val Glu Leu Asn Ile 
        195                 200                 205             


Leu Gly Phe Leu Leu Pro Leu Ala Ala Ile Val Phe Phe Asn Tyr His 
    210                 215                 220                 


Ile Leu Ala Ser Leu Arg Xaa Arg Glu Glu Val Ser Arg Xaa Ser Ser 
225                 230                 235                 240 


Leu Asn Pro Val Ile Tyr Val Phe Val Gly Arg Leu Phe Arg Xaa Lys 
                245                 250                 255     


Pro Ala Leu Ser Arg Trp Leu Ile Lys Ile Leu Ser Arg Ser Cys Lys 
            260                 265                 270         


Asn Gln Ser His Xaa Arg Glu Glu Arg Ala Gly Arg 
        275                 280                 


<210> 4147
<211> 391
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<400> 4147
Met Phe Ser Pro Trp Lys Ile Ser Met Phe Leu Ser Val Arg Glu Asp 
1               5                   10                  15      


Ser Val Pro Xaa Xaa Ala Ser Phe Ser Ala Asp Met Leu Asn Val Xaa 
            20                  25                  30          


Leu Gln Gly Pro Xaa Leu Asn Gly Xaa Phe Ala Gln Ser Lys Cys Pro 
        35                  40                  45              


Gln Val Glu Trp Leu Gly Trp Leu Asn Xaa Ile Gln Pro Pro Phe Leu 
    50                  55                  60                  


Trp Val Leu Phe Val Leu Ala Xaa Leu Glu Asn Ile Phe Val Leu Ser 
65                  70                  75                  80  


Val Phe Cys Leu His Lys Ser Ser Cys Xaa Val Ala Glu Ile Tyr Leu 
                85                  90                  95      


Gly Asn Leu Ala Ala Ala Asp Leu Ile Leu Ala Cys Gly Leu Pro Phe 
            100                 105                 110         


Trp Ala Ile Xaa Ile Ser Asn Asn Phe Asp Trp Leu Phe Gly Glu Xaa 
        115                 120                 125             


Leu Cys Arg Val Val Asn Ala Ile Ile Ser Met Asn Leu Tyr Ser Ser 
    130                 135                 140                 


Ile Cys Phe Leu Met Leu Val Ser Ile Asp Arg Tyr Leu Ala Leu Val 
145                 150                 155                 160 


Lys Xaa Met Ser Met Gly Arg Met Arg Gly Val Arg Trp Ala Lys Leu 
                165                 170                 175     


Tyr Ser Leu Val Ile Trp Gly Cys Xaa Leu Leu Leu Ser Ser Pro Met 
            180                 185                 190         


Leu Val Phe Arg Xaa Met Lys Glu Tyr Ser Asp Glu Gly His Asn Val 
        195                 200                 205             


Xaa Ala Cys Val Ile Ser Tyr Pro Ser Leu Ile Trp Glu Val Phe Xaa 
    210                 215                 220                 


Asn Met Leu Leu Asn Val Val Gly Phe Leu Leu Pro Leu Ser Val Ile 
225                 230                 235                 240 


Xaa Phe Cys Xaa Met Gln Ile Met Gln Val Leu Arg Asn Asn Glu Met 
                245                 250                 255     


Gln Lys Phe Lys Glu Ile Gln Xaa Glu Arg Arg Ala Xaa Val Leu Val 
            260                 265                 270         


Leu Val Val Leu Leu Leu Phe Ile Ile Cys Trp Leu Pro Phe Gln Ile 
        275                 280                 285             


Ser Xaa Phe Leu Asp Xaa Leu His Arg Leu Gly Ile Leu Ser Ser Cys 
    290                 295                 300                 


Gln Asp Glu Arg Ile Ile Asp Val Ile Xaa Gln Ile Ala Ser Phe Met 
305                 310                 315                 320 


Ala Tyr Ser Asn Ser Cys Leu Asn Pro Leu Val Tyr Val Ile Val Gly 
                325                 330                 335     


Lys Arg Phe Arg Lys Lys Ser Trp Glu Val Tyr Gln Gly Val Cys Gln 
            340                 345                 350         


Lys Gly Gly Cys Arg Ser Glu Pro Ile Gln Met Glu Asn Ser Met Gly 
        355                 360                 365             


Xaa Leu Arg Xaa Ser Ile Ser Val Glu Arg Gln Ile His Lys Leu Gln 
    370                 375                 380                 


Asp Trp Ala Gly Ser Arg Gln 
385                 390     


<210> 4148
<211> 364
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<400> 4148
Met Leu Asn Val Xaa Leu Gln Gly Pro Xaa Leu Asn Gly Xaa Phe Ala 
1               5                   10                  15      


Gln Ser Lys Cys Pro Gln Val Glu Trp Leu Gly Trp Leu Asn Xaa Ile 
            20                  25                  30          


Gln Pro Pro Phe Leu Trp Val Leu Phe Val Leu Ala Xaa Leu Glu Asn 
        35                  40                  45              


Ile Phe Val Leu Ser Val Phe Cys Leu His Lys Ser Ser Cys Xaa Val 
    50                  55                  60                  


Ala Glu Ile Tyr Leu Gly Asn Leu Ala Ala Ala Asp Leu Ile Leu Ala 
65                  70                  75                  80  


Cys Gly Leu Pro Phe Trp Ala Ile Xaa Ile Ser Asn Asn Phe Asp Trp 
                85                  90                  95      


Leu Phe Gly Glu Xaa Leu Cys Arg Val Val Asn Ala Ile Ile Ser Met 
            100                 105                 110         


Asn Leu Tyr Ser Ser Ile Cys Phe Leu Met Leu Val Ser Ile Asp Arg 
        115                 120                 125             


Tyr Leu Ala Leu Val Lys Xaa Met Ser Met Gly Arg Met Arg Gly Val 
    130                 135                 140                 


Arg Trp Ala Lys Leu Tyr Ser Leu Val Ile Trp Gly Cys Xaa Leu Leu 
145                 150                 155                 160 


Leu Ser Ser Pro Met Leu Val Phe Arg Xaa Met Lys Glu Tyr Ser Asp 
                165                 170                 175     


Glu Gly His Asn Val Xaa Ala Cys Val Ile Ser Tyr Pro Ser Leu Ile 
            180                 185                 190         


Trp Glu Val Phe Xaa Asn Met Leu Leu Asn Val Val Gly Phe Leu Leu 
        195                 200                 205             


Pro Leu Ser Val Ile Xaa Phe Cys Xaa Met Gln Ile Met Gln Val Leu 
    210                 215                 220                 


Arg Asn Asn Glu Met Gln Lys Phe Lys Glu Ile Gln Xaa Glu Arg Arg 
225                 230                 235                 240 


Ala Xaa Val Leu Val Leu Val Val Leu Leu Leu Phe Ile Ile Cys Trp 
                245                 250                 255     


Leu Pro Phe Gln Ile Ser Xaa Phe Leu Asp Xaa Leu His Arg Leu Gly 
            260                 265                 270         


Ile Leu Ser Ser Cys Gln Asp Glu Arg Ile Ile Asp Val Ile Xaa Gln 
        275                 280                 285             


Ile Ala Ser Phe Met Ala Tyr Ser Asn Ser Cys Leu Asn Pro Leu Val 
    290                 295                 300                 


Tyr Val Ile Val Gly Lys Arg Phe Arg Lys Lys Ser Trp Glu Val Tyr 
305                 310                 315                 320 


Gln Gly Val Cys Gln Lys Gly Gly Cys Arg Ser Glu Pro Ile Gln Met 
                325                 330                 335     


Glu Asn Ser Met Gly Xaa Leu Arg Xaa Ser Ile Ser Val Glu Arg Gln 
            340                 345                 350         


Ile His Lys Leu Gln Asp Trp Ala Gly Ser Arg Gln 
        355                 360                 


<210> 4149
<211> 329
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<400> 4149
Met Cys Gly Ala Xaa Ser Phe Leu His Glu Cys Xaa Arg Leu Ile Leu 
1               5                   10                  15      


Val Xaa Xaa Gln Asn Ala Glu Phe Leu Gln Lys Gly Leu Gln Val His 
            20                  25                  30          


Xaa Cys Phe Gly Val Tyr Pro His Ala Ser Val Trp His Asp Cys Ala 
        35                  40                  45              


Ser Gln Lys Lys Gly Cys Ala Val Tyr Leu His Val Ser Val Glu Phe 
    50                  55                  60                  


Asn Lys Leu Ile Pro Glu Asn Gly Phe Ile Lys Phe His Gln Val Arg 
65                  70                  75                  80  


Arg Val Met Xaa Ile Leu Phe Leu Xaa Met Val Ile Ser Tyr Phe Gly 
                85                  90                  95      


Cys Met Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly 
            100                 105                 110         


Gly Leu Ala Tyr Pro Gly Val Arg Xaa His Gly Xaa Leu Glu Ser Val 
        115                 120                 125             


Asn Gly Pro Lys Ala Gly Ser Arg Gly Leu Xaa Ser Leu Ala Asp Xaa 
    130                 135                 140                 


Phe Glu His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg 
145                 150                 155                 160 


Pro Asn Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Xaa Ser Arg Val 
                165                 170                 175     


Met Leu Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu 
            180                 185                 190         


Glu Glu Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val 
        195                 200                 205             


Arg Arg His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp 
    210                 215                 220                 


Ser Ile Ser Glu Trp Val Xaa Ala Ala Asp Lys Lys Xaa Ala Val Asp 
225                 230                 235                 240 


Met Ser Gly Gly Xaa Val Xaa Val Leu Glu Lys Val Pro Val Ser Lys 
                245                 250                 255     


Gly Gln Leu Lys Gln Tyr Phe Tyr Glu Xaa Lys Cys Asn Pro Met Gly 
            260                 265                 270         


Tyr Xaa Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser 
        275                 280                 285             


Gln Cys Arg Xaa Xaa Gln Ser Tyr Val Arg Ala Leu Xaa Met Asp Ser 
    290                 295                 300                 


Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Xaa Ser Cys Val 
305                 310                 315                 320 


Cys Xaa Leu Xaa Ile Lys Arg Gly Arg 
                325                 


<210> 4150
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<400> 4150
Met Cys Gly Ala Xaa Ser Phe Leu His Glu Cys Xaa Arg Leu Ile Leu 
1               5                   10                  15      


Val Xaa Xaa Gln Asn Ala Glu Phe Leu Gln Lys Gly Leu Gln Val His 
            20                  25                  30          


Xaa Cys Phe Gly Val Tyr Pro His Ala Ser Val Trp His Asp Cys Ala 
        35                  40                  45              


Ser Gln Lys Lys Gly Cys Ala Val Tyr Leu His Val Ser Val Glu Phe 
    50                  55                  60                  


Asn Lys Leu Ile Pro Glu Asn Gly Phe Ile Lys Gly Trp 
65                  70                  75          


<210> 4151
<211> 255
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<400> 4151
Met Phe His Gln Val Arg Arg Val Met Xaa Ile Leu Phe Leu Xaa Met 
1               5                   10                  15      


Val Ile Ser Tyr Phe Gly Cys Met Lys Ala Ala Pro Met Lys Glu Ala 
            20                  25                  30          


Asn Ile Arg Gly Gln Gly Gly Leu Ala Tyr Pro Gly Val Arg Xaa His 
        35                  40                  45              


Gly Xaa Leu Glu Ser Val Asn Gly Pro Lys Ala Gly Ser Arg Gly Leu 
    50                  55                  60                  


Xaa Ser Leu Ala Asp Xaa Phe Glu His Val Ile Glu Glu Leu Leu Asp 
65                  70                  75                  80  


Glu Asp Gln Lys Val Arg Pro Asn Glu Glu Asn Asn Lys Asp Ala Asp 
                85                  90                  95      


Leu Tyr Xaa Ser Arg Val Met Leu Ser Ser Gln Val Pro Leu Glu Pro 
            100                 105                 110         


Pro Leu Leu Phe Leu Leu Glu Glu Tyr Lys Asn Tyr Leu Asp Ala Ala 
        115                 120                 125             


Asn Met Ser Met Arg Val Arg Arg His Ser Asp Pro Ala Arg Arg Gly 
    130                 135                 140                 


Glu Leu Ser Val Cys Asp Ser Ile Ser Glu Trp Val Xaa Ala Ala Asp 
145                 150                 155                 160 


Lys Lys Xaa Ala Val Asp Met Ser Gly Gly Xaa Val Xaa Val Leu Glu 
                165                 170                 175     


Lys Val Pro Val Ser Lys Gly Gln Leu Lys Gln Tyr Phe Tyr Glu Xaa 
            180                 185                 190         


Lys Cys Asn Pro Met Gly Tyr Xaa Lys Glu Gly Cys Arg Gly Ile Asp 
        195                 200                 205             


Lys Arg His Trp Asn Ser Gln Cys Arg Xaa Xaa Gln Ser Tyr Val Arg 
    210                 215                 220                 


Ala Leu Xaa Met Asp Ser Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg 
225                 230                 235                 240 


Ile Asp Xaa Ser Cys Val Cys Xaa Leu Xaa Ile Lys Arg Gly Arg 
                245                 250                 255 


<210> 4152
<211> 262
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<400> 4152
Met Gln Ser Arg Glu Glu Glu Trp Phe His Gln Val Arg Arg Val Met 
1               5                   10                  15      


Xaa Ile Leu Phe Leu Xaa Met Val Ile Ser Tyr Phe Gly Cys Met Lys 
            20                  25                  30          


Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu Ala 
        35                  40                  45              


Tyr Pro Gly Val Arg Xaa His Gly Xaa Leu Glu Ser Val Asn Gly Pro 
    50                  55                  60                  


Lys Ala Gly Ser Arg Gly Leu Xaa Ser Leu Ala Asp Xaa Phe Glu His 
65                  70                  75                  80  


Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn Glu 
                85                  90                  95      


Glu Asn Asn Lys Asp Ala Asp Leu Tyr Xaa Ser Arg Val Met Leu Ser 
            100                 105                 110         


Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu Tyr 
        115                 120                 125             


Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg His 
    130                 135                 140                 


Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile Ser 
145                 150                 155                 160 


Glu Trp Val Xaa Ala Ala Asp Lys Lys Xaa Ala Val Asp Met Ser Gly 
                165                 170                 175     


Gly Xaa Val Xaa Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln Leu 
            180                 185                 190         


Lys Gln Tyr Phe Tyr Glu Xaa Lys Cys Asn Pro Met Gly Tyr Xaa Lys 
        195                 200                 205             


Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys Arg 
    210                 215                 220                 


Xaa Xaa Gln Ser Tyr Val Arg Ala Leu Xaa Met Asp Ser Lys Lys Arg 
225                 230                 235                 240 


Ile Gly Trp Arg Phe Ile Arg Ile Asp Xaa Ser Cys Val Cys Xaa Leu 
                245                 250                 255     


Xaa Ile Lys Arg Gly Arg 
            260         


<210> 4153
<211> 247
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<400> 4153
Met Xaa Ile Leu Phe Leu Xaa Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Xaa His Gly Xaa Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Xaa Ser Leu Ala Asp Xaa Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Xaa Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Xaa Ala Ala Asp Lys Lys Xaa Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Xaa Val Xaa Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Xaa Lys Cys Asn Pro Met Gly Tyr Xaa 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Xaa Xaa Gln Ser Tyr Val Arg Ala Leu Xaa Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Xaa Ser Cys Val Cys Xaa 
225                 230                 235                 240 


Leu Xaa Ile Lys Arg Gly Arg 
                245         


<210> 4154
<211> 846
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<400> 4154
Met Phe Arg Arg Ala Arg Leu Ser Val Lys Pro Asn Val Arg Pro Gly 
1               5                   10                  15      


Val Gly Ala Arg Gly Ser Xaa Ala Ser Asn Pro Gln Arg Gly Arg Glu 
            20                  25                  30          


Ser Pro Arg Pro Pro Asp Pro Ala Xaa Asp Ser Ala Ser Lys Pro Ala 
        35                  40                  45              


Glu Pro Xaa Asp Val Pro Xaa Val Asp Phe Gly Gly Ala Glu Pro Gln 
    50                  55                  60                  


Glu Lys Ala Pro Arg Ser Ser Xaa Glu Lys Xaa Gly Gly Asp Asn Asp 
65                  70                  75                  80  


Val Glu Glu Ser Ser Arg Ser Ser Ser Xaa Val Ser Gln Arg Arg Lys 
                85                  90                  95      


Arg Ile Ser Ser Xaa Ser Ser Leu Val Lys Ser Ser Val Ser Val Pro 
            100                 105                 110         


Ser Glu Ser His Pro Leu Ser Xaa Ile Asn Gln Glu Ala Pro Gln Pro 
        115                 120                 125             


Xaa Ala Xaa Ser Xaa Lys Glu Lys Gln Pro Cys Ser Asp Arg Tyr Arg 
    130                 135                 140                 


Ile Tyr Lys Ala Gln Lys Leu Arg Glu Met Leu Lys Glu Glu Leu Arg 
145                 150                 155                 160 


Lys Glu Lys Lys Gln Trp Lys Asn Lys Tyr Ala Ile Asn Glu Ser Gln 
                165                 170                 175     


Arg Pro Pro Asp Arg Ser Lys Met Xaa Met Arg Asp Phe Ile Tyr Tyr 
            180                 185                 190         


Leu Pro Asp Asn Asn Pro Met Xaa Ser Ser Leu Glu Gln Glu Lys Lys 
        195                 200                 205             


Xaa Glu Lys Pro Ser Xaa Pro Val Gln Xaa Arg Glu Gln Glu Gly Lys 
    210                 215                 220                 


Ser Xaa Pro Asn Ala Glu Asp Asn Glu Met Glu Glu Glu Xaa Asp Asp 
225                 230                 235                 240 


Gly Pro Leu Leu Val Pro Arg Val Lys Val Ala Glu Asp Gly Ser Ile 
                245                 250                 255     


Ile Leu Asp Glu Glu Ser Leu Xaa Val Glu Val Leu Arg Xaa Lys Gly 
            260                 265                 270         


Pro Cys Val Val Glu Glu Asn Asp Pro Ile Phe Glu Arg Gly Ser Xaa 
        275                 280                 285             


Xaa Xaa Tyr Ser Ser Phe Arg Lys Asn Tyr Tyr Ser Lys Pro Trp Ser 
    290                 295                 300                 


Asn Lys Glu Xaa Asp Met Phe Phe Leu Ala Ile Ser Met Val Gly Xaa 
305                 310                 315                 320 


Asp Phe Ser Met Ile Gly Gln Leu Phe Pro His Arg Ala Arg Ile Glu 
                325                 330                 335     


Ile Lys Asn Lys Phe Lys Arg Glu Glu Lys Xaa Asn Gly Trp Arg Ile 
            340                 345                 350         


Asp Lys Ala Phe Gln Glu Lys Arg Pro Phe Asp Phe Asp Phe Phe Ala 
        355                 360                 365             


His Leu Leu Gln Lys Val Leu Ala Glu Glu Glu Lys Arg Lys Gln Lys 
    370                 375                 380                 


Ser Val Lys Asn His Ser Leu Lys Glu Lys Lys Ser Xaa Lys Pro Arg 
385                 390                 395                 400 


Lys Asn Val Lys Val Lys Lys Val Ala Cys Glu Gly Val Asn Asn Asp 
                405                 410                 415     


Pro Asp Glu Ser Met Ser Ser Arg Ile Ser Asp Xaa Glu Arg Ser Gln 
            420                 425                 430         


Lys Asp Ala Gln Xaa Val Glu Glu Glu Ser Leu Xaa Leu Ser Arg Glu 
        435                 440                 445             


Asp Ala Glu Gln Val Ala Leu Glu Val Asp Leu Asn Gln Lys Lys Arg 
    450                 455                 460                 


Arg Arg Lys Lys Gln Asp Gly Ala Asn Glu Leu Gly Val Asn Asn Leu 
465                 470                 475                 480 


Leu Glu Asn Ala Xaa Val Gln Ala Gly Pro Ser Lys Gly Glu Lys His 
                485                 490                 495     


Lys Asn Lys Cys Gln Ala Ile Arg Pro Glu Leu Lys Glu Gly Glu Cys 
            500                 505                 510         


Ser Lys Glu Gln Met Leu Ser Cys Xaa Gln Asn Ile Asp Gly Ile Val 
        515                 520                 525             


Gly Phe Ala Ser Xaa Glu Lys Val Glu Lys Arg Xaa Asp Pro Ile Leu 
    530                 535                 540                 


Ser Leu Ser Asn Gln Gln Asp Ala Xaa Ser Val Ala Xaa Glu Ser Ser 
545                 550                 555                 560 


Glu Ser Ser Xaa Ser Asp Leu Pro Ser Phe Glu Val Gly Ile Arg Ala 
                565                 570                 575     


Leu Cys Glu Val Asn Asn Ala Glu Gly Ser Cys Ile Glu Glu Arg Asn 
            580                 585                 590         


Val Asp Leu Lys Asn Asn Ser Leu Glu Ile Asp Gln Xaa Glu Asn Val 
        595                 600                 605             


Lys Pro Met Leu Arg Gly Arg Phe Gln Arg Pro Lys Pro Asn Leu Ser 
    610                 615                 620                 


Arg Ala Gly Lys Lys Ser Val Leu Ser Gln Gly Lys Xaa Glu Ser Glu 
625                 630                 635                 640 


Ser Lys Asn Ser His Ser Lys Xaa Ser Val Glu Lys Asn His Val Glu 
                645                 650                 655     


Lys Asp Lys Met Asn Xaa Leu Asp Ile Leu Arg Met Glu Xaa Xaa Glu 
            660                 665                 670         


Arg Glu Asn Pro Glu Ala Glu Xaa Val Ser Val Leu Gly Glu Lys Asn 
        675                 680                 685             


Cys Leu Gln Glu Gly Ser Gln Leu Lys Ala Leu Arg Pro Val Gln Val 
    690                 695                 700                 


Arg Gly Arg Leu Gln Lys Pro Lys Pro Asn Ala Gly Lys Ala Ala Glu 
705                 710                 715                 720 


Arg Lys Glu Ile Leu Ile Ser Gln Glu Glu Ile Gly Ala Asn Val Glu 
                725                 730                 735     


Lys Asn Glu Asn Glu Ser Cys Ala Asp Arg Asp Xaa Pro Gln His Met 
            740                 745                 750         


Glu Asp Gln Ser Arg Lys Asp Phe Glu Glu Glu Asp Val Ile Leu Gln 
        755                 760                 765             


Pro Glu Lys Asn Asp Ser Phe Gln Asn Val Gln Pro Asp Glu Pro Lys 
    770                 775                 780                 


Val Leu Asn Glu Cys Leu Ser Val Gln Glu Asn Asn Lys Ala Asn Lys 
785                 790                 795                 800 


Leu Asn Gln Val Pro Ile Leu Arg Xaa Arg Phe Gln Lys Pro Lys Pro 
                805                 810                 815     


Asn Ile Gly Arg Gly Xaa Gly Arg Arg Glu Ile Ser Ser Lys Glu Glu 
            820                 825                 830         


Val Leu Glu Lys Ile Leu Ser Leu Gly Lys Trp Arg Gln His 
        835                 840                 845     


<210> 4155
<211> 2624
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1131)..(1131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1138)..(1138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1314)..(1314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1328)..(1328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1365)..(1365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1396)..(1396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1454)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1485)..(1485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1503)..(1503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1517)..(1517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1551)..(1551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1556)..(1556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1613)..(1613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1619)..(1619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1627)..(1627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1659)..(1659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1662)..(1662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1678)..(1678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1705)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1726)..(1726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1738)..(1738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1776)..(1776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1795)..(1795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1804)..(1804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1815)..(1816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1820)..(1820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1841)..(1841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1853)..(1853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1867)..(1867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1921)..(1921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1928)..(1928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1947)..(1947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1950)..(1951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1967)..(1968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1978)..(1978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1983)..(1983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1988)..(1988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1991)..(1991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2048)..(2049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2081)..(2081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2083)..(2083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2086)..(2086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2091)..(2091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2110)..(2110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2113)..(2113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2128)..(2128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2135)..(2135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2139)..(2139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2147)..(2147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2158)..(2159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2177)..(2177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2186)..(2186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2212)..(2212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2216)..(2216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2243)..(2243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2250)..(2250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2252)..(2252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2269)..(2269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2289)..(2289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2302)..(2302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2305)..(2305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2325)..(2325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2338)..(2338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2389)..(2389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2398)..(2399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2407)..(2407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2413)..(2413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2425)..(2425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2429)..(2429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2431)..(2432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2477)..(2477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2490)..(2490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2569)..(2570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2580)..(2580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2606)..(2607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2623)..(2623)
<223> Selenocysteine

<400> 4155
Met Phe Arg Arg Ala Arg Leu Ser Val Lys Pro Asn Val Arg Pro Gly 
1               5                   10                  15      


Val Gly Ala Arg Gly Ser Xaa Ala Ser Asn Pro Gln Arg Gly Arg Glu 
            20                  25                  30          


Ser Pro Arg Pro Pro Asp Pro Ala Xaa Asp Ser Ala Ser Lys Pro Ala 
        35                  40                  45              


Glu Pro Xaa Asp Val Pro Xaa Val Asp Phe Gly Gly Ala Glu Pro Gln 
    50                  55                  60                  


Glu Lys Ala Pro Arg Ser Ser Xaa Glu Lys Xaa Gly Gly Asp Asn Asp 
65                  70                  75                  80  


Val Glu Glu Ser Ser Arg Ser Ser Ser Xaa Val Ser Gln Arg Arg Lys 
                85                  90                  95      


Arg Ile Ser Ser Xaa Ser Ser Leu Val Lys Ser Ser Val Ser Val Pro 
            100                 105                 110         


Ser Glu Ser His Pro Leu Ser Xaa Ile Asn Gln Glu Ala Pro Gln Pro 
        115                 120                 125             


Xaa Ala Xaa Ser Xaa Lys Glu Lys Gln Pro Cys Ser Asp Arg Tyr Arg 
    130                 135                 140                 


Ile Tyr Lys Ala Gln Lys Leu Arg Glu Met Leu Lys Glu Glu Leu Arg 
145                 150                 155                 160 


Lys Glu Lys Lys Gln Trp Lys Asn Lys Tyr Ala Ile Asn Glu Ser Gln 
                165                 170                 175     


Arg Pro Pro Asp Arg Ser Lys Met Xaa Met Arg Asp Phe Ile Tyr Tyr 
            180                 185                 190         


Leu Pro Asp Asn Asn Pro Met Xaa Ser Ser Leu Glu Gln Glu Lys Lys 
        195                 200                 205             


Xaa Glu Lys Pro Ser Xaa Pro Val Gln Xaa Arg Glu Gln Glu Gly Lys 
    210                 215                 220                 


Ser Xaa Pro Asn Ala Glu Asp Asn Glu Met Glu Glu Glu Xaa Asp Asp 
225                 230                 235                 240 


Gly Pro Leu Leu Val Pro Arg Val Lys Val Ala Glu Asp Gly Ser Ile 
                245                 250                 255     


Ile Leu Asp Glu Glu Ser Leu Xaa Val Glu Val Leu Arg Xaa Lys Gly 
            260                 265                 270         


Pro Cys Val Val Glu Glu Asn Asp Pro Ile Phe Glu Arg Gly Ser Xaa 
        275                 280                 285             


Xaa Xaa Tyr Ser Ser Phe Arg Lys Asn Tyr Tyr Ser Lys Pro Trp Ser 
    290                 295                 300                 


Asn Lys Glu Xaa Asp Met Phe Phe Leu Ala Ile Ser Met Val Gly Xaa 
305                 310                 315                 320 


Asp Phe Ser Met Ile Gly Gln Leu Phe Pro His Arg Ala Arg Ile Glu 
                325                 330                 335     


Ile Lys Asn Lys Phe Lys Arg Glu Glu Lys Xaa Asn Gly Trp Arg Ile 
            340                 345                 350         


Asp Lys Ala Phe Gln Glu Lys Arg Pro Phe Asp Phe Asp Phe Phe Ala 
        355                 360                 365             


His Leu Leu Gln Lys Val Leu Ala Glu Glu Glu Lys Arg Lys Gln Lys 
    370                 375                 380                 


Ser Val Lys Asn His Ser Leu Lys Glu Lys Lys Ser Xaa Lys Pro Arg 
385                 390                 395                 400 


Lys Asn Val Lys Val Lys Lys Val Ala Cys Glu Gly Val Asn Asn Asp 
                405                 410                 415     


Pro Asp Glu Ser Met Ser Ser Arg Ile Ser Asp Xaa Glu Arg Ser Gln 
            420                 425                 430         


Lys Asp Ala Gln Xaa Val Glu Glu Glu Ser Leu Xaa Leu Ser Arg Glu 
        435                 440                 445             


Asp Ala Glu Gln Val Ala Leu Glu Val Asp Leu Asn Gln Lys Lys Arg 
    450                 455                 460                 


Arg Arg Lys Lys Gln Asp Gly Ala Asn Glu Leu Gly Val Asn Asn Leu 
465                 470                 475                 480 


Leu Glu Asn Ala Xaa Val Gln Ala Gly Pro Ser Lys Gly Glu Lys His 
                485                 490                 495     


Lys Asn Lys Cys Gln Ala Ile Arg Pro Glu Leu Lys Glu Gly Glu Cys 
            500                 505                 510         


Ser Lys Glu Gln Met Leu Ser Cys Xaa Gln Asn Ile Asp Gly Ile Val 
        515                 520                 525             


Gly Phe Ala Ser Xaa Glu Lys Val Glu Lys Arg Xaa Asp Pro Ile Leu 
    530                 535                 540                 


Ser Leu Ser Asn Gln Gln Asp Ala Xaa Ser Val Ala Xaa Glu Ser Ser 
545                 550                 555                 560 


Glu Ser Ser Xaa Ser Asp Leu Pro Ser Phe Glu Val Gly Ile Arg Ala 
                565                 570                 575     


Leu Cys Glu Val Asn Asn Ala Glu Gly Ser Cys Ile Glu Glu Arg Asn 
            580                 585                 590         


Val Asp Leu Lys Asn Asn Ser Leu Glu Ile Asp Gln Xaa Glu Asn Val 
        595                 600                 605             


Lys Pro Met Leu Arg Gly Arg Phe Gln Arg Pro Lys Pro Asn Leu Ser 
    610                 615                 620                 


Arg Ala Gly Lys Lys Ser Val Leu Ser Gln Gly Lys Xaa Glu Ser Glu 
625                 630                 635                 640 


Ser Lys Asn Ser His Ser Lys Xaa Ser Val Glu Lys Asn His Val Glu 
                645                 650                 655     


Lys Asp Lys Met Asn Xaa Leu Asp Ile Leu Arg Met Glu Xaa Xaa Glu 
            660                 665                 670         


Arg Glu Asn Pro Glu Ala Glu Xaa Val Ser Val Leu Gly Glu Lys Asn 
        675                 680                 685             


Cys Leu Gln Glu Gly Ser Gln Leu Lys Ala Leu Arg Pro Val Gln Val 
    690                 695                 700                 


Arg Gly Arg Leu Gln Lys Pro Lys Pro Asn Ala Gly Lys Ala Ala Glu 
705                 710                 715                 720 


Arg Lys Glu Ile Leu Ile Ser Gln Glu Glu Ile Gly Ala Asn Val Glu 
                725                 730                 735     


Lys Asn Glu Asn Glu Ser Cys Ala Asp Arg Asp Xaa Pro Gln His Met 
            740                 745                 750         


Glu Asp Gln Ser Arg Lys Asp Phe Glu Glu Glu Asp Val Ile Leu Gln 
        755                 760                 765             


Pro Glu Lys Asn Asp Ser Phe Gln Asn Val Gln Pro Asp Glu Pro Lys 
    770                 775                 780                 


Val Leu Asn Glu Cys Leu Ser Val Gln Glu Asn Asn Lys Ala Asn Lys 
785                 790                 795                 800 


Leu Asn Gln Val Pro Ile Leu Arg Xaa Arg Phe Gln Lys Pro Lys Pro 
                805                 810                 815     


Asn Ile Gly Arg Gly Xaa Gly Arg Arg Glu Ile Ser Ser Lys Glu Glu 
            820                 825                 830         


Val Leu Glu Lys Ile Leu Val Ser Gly Glu Met Ala Ala Ala Leu Arg 
        835                 840                 845             


Glu Xaa Val Arg Leu Asp Xaa Ser Pro Lys Glu Met Val Pro Ala Glu 
    850                 855                 860                 


Ile Asn Xaa Lys Glu Met Gln Ser Asp Leu Lys Glu Xaa Gly Arg Arg 
865                 870                 875                 880 


Ala Ile Ser Pro Arg Glu Lys Ile Leu Asp Val Ile Asp Asp Xaa Ile 
                885                 890                 895     


Glu Met Glu Xaa Gly Leu Lys Ala Met Gly Arg Glu Ile Cys Leu Arg 
            900                 905                 910         


Glu Lys Xaa Pro Glu Val Ile Asp Ala Xaa Glu Glu Ile Asp Lys Asp 
        915                 920                 925             


Leu Glu Glu Ala Gly Arg Arg Glu Ile Ser Pro Gln Lys Asn Gly Pro 
    930                 935                 940                 


Glu Glu Val Lys Pro Leu Gly Glu Val Glu Xaa Asp Leu Lys Ala Xaa 
945                 950                 955                 960 


Gly Asn Glu Ser Ser Pro Arg Glu Lys Xaa Pro Glu Val Xaa Asp Ala 
                965                 970                 975     


Xaa Glu Glu Ile Asp Lys Asn Leu Glu Glu Xaa Gly Arg Arg Lys Ile 
            980                 985                 990         


Ser Pro Arg Glu Asn Gly Pro Glu  Glu Val Lys Pro Val  Asp Glu Met 
        995                 1000                 1005             


Glu Xaa  Asp Leu Asn Ala Xaa  Gly Arg Glu Ser Ser  Pro Arg Glu 
    1010                 1015                 1020             


Lys Xaa  Pro Glu Val Ile Asp  Ala Xaa Glu Glu Ile  Asp Leu Glu 
    1025                 1030                 1035             


Glu Xaa  Glu Arg Glu Val Ser  Pro Gln Glu Asn Gly  Leu Glu Glu 
    1040                 1045                 1050             


Val Lys  Pro Leu Gly Glu Met  Glu Xaa Asp Leu Lys  Ala Xaa Gly 
    1055                 1060                 1065             


Arg Asp  Ser Phe Pro Arg Gly  Lys Xaa Pro Glu Val  Ile Asp Ala 
    1070                 1075                 1080             


Ile Glu  Glu Ile Glu Ile Asp  Leu Glu Glu Xaa Glu  Arg Glu Ile 
    1085                 1090                 1095             


Ser Pro  Gln Glu Asn Gly Leu  Glu Glu Val Lys Pro  Leu Gly Glu 
    1100                 1105                 1110             


Met Gln  Xaa Asp Leu Lys Ala  Xaa Gly Arg Glu Ile  Ser Pro Arg 
    1115                 1120                 1125             


Glu Lys  Xaa Pro Glu Val Ile  Asp Ala Xaa Glu Glu  Ile Asp Lys 
    1130                 1135                 1140             


Asp Leu  Glu Glu Xaa Gly Arg  Arg Glu Ile Ser Pro  Glu Glu Asn 
    1145                 1150                 1155             


Gly Pro  Glu Glu Val Lys Pro  Val Asp Glu Met Glu  Xaa Asp Leu 
    1160                 1165                 1170             


Lys Xaa  Xaa Gly Arg Glu Gly  Ser Ser Arg Glu Lys  Xaa Arg Glu 
    1175                 1180                 1185             


Val Ile  Asp Ala Ala Glu Val  Ile Glu Xaa Asp Leu  Glu Glu Xaa 
    1190                 1195                 1200             


Glu Arg  Glu Ile Ser Pro Gln  Glu Asn Gly Pro Glu  Glu Val Lys 
    1205                 1210                 1215             


Pro Val  Gly Lys Met Glu Xaa  Asp Leu Lys Glu Ile  Arg Glu Glu 
    1220                 1225                 1230             


Ile Ser  Gln Arg Glu Lys Val  Leu Ala Glu Phe Ser  Ala Ile Arg 
    1235                 1240                 1245             


Glu Lys  Glu Ile Asp Leu Lys  Glu Xaa Gly Lys Arg  Asp Ile Pro 
    1250                 1255                 1260             


Ile Met  Glu Lys Val Ser Gly  Lys Met Ala Val Val  Glu Glu Met 
    1265                 1270                 1275             


Glu Ala  Asp Leu Lys Glu Xaa  Gly Lys Glu Asn Phe  Arg Glu Arg 
    1280                 1285                 1290             


Gly Ser  Glu Glu Ile Cys Val  Xaa Glu Glu Lys Val  Ala Glu Leu 
    1295                 1300                 1305             


Lys Gln  Xaa Gly Lys Xaa Asp  Ile Ser Pro Arg Glu  Asn Glu Leu 
    1310                 1315                 1320             


Glu Glu  Xaa Ser Xaa Ser Arg  Gln Xaa Asp Xaa His  Leu Met Gln 
    1325                 1330                 1335             


Ser Gly  Ser Asn Asp Phe Ser  Ala Val Pro Ser Leu  Asp Ile Gln 
    1340                 1345                 1350             


Asn Ile  Ser Ser Glu Val Leu  Ser Met Met His Xaa  Pro Val Glu 
    1355                 1360                 1365             


Glu Lys  Arg Asn Ser Glu Lys  Glu Val Ser Ser His  Phe Ser His 
    1370                 1375                 1380             


Phe Lys  Ile Ser Ser Gln Xaa  His Glu Ser Asp Lys  Xaa Glu Val 
    1385                 1390                 1395             


Gln Gly  Ile Gln Ser Pro Asp  Val Pro Glu Gln Phe  Ser Asp Ile 
    1400                 1405                 1410             


Asn Leu  Ser Lys Ser Leu Pro  Gln Glu Gln Lys Pro  Leu Glu Ile 
    1415                 1420                 1425             


Lys Pro  Ala Pro Phe Val Arg  Ser Arg Phe Lys Arg  Pro Lys Pro 
    1430                 1435                 1440             


Asn Leu  Ala Arg Ala Ala Leu  Lys Arg Glu Xaa Xaa  Glu Ser Glu 
    1445                 1450                 1455             


Lys Tyr  Ile Tyr Glu Lys Lys  Ser Glu Xaa Lys Lys  Met Glu Xaa 
    1460                 1465                 1470             


Ile Val  Met Gln Glu Asn Asn  Glu Gln Xaa Asp Xaa  Leu Pro Ser 
    1475                 1480                 1485             


Gln His  Asp Glu Ala Ser Leu  Met Ile Ser Arg Glu  Lys Asp Xaa 
    1490                 1495                 1500             


Leu Gly  His Arg Asn Glu Glu  Ala Val Ile Leu Pro  Cys Xaa Gln 
    1505                 1510                 1515             


Xaa Glu  Arg Asn Leu Ser Pro  Ser Asn Ser Cys Glu  Pro Lys Glu 
    1520                 1525                 1530             


Glu Ser  Gln Ser Ala Pro Val  Gln Lys Asn Asp Ser  Val Val Ser 
    1535                 1540                 1545             


Val Gly  Xaa Asn Asn Val Asn  Xaa Phe Gln Gln Glu  Met Lys Glu 
    1550                 1555                 1560             


Ser Val  Ile Gln Xaa Ala Arg  Gln Val Arg Gly Arg  Leu Gln Arg 
    1565                 1570                 1575             


Pro Arg  Pro Asn Ile Arg Lys  Xaa Gly Gln Arg Gln  Ile Val Asp 
    1580                 1585                 1590             


Lys Gly  Glu Ala Lys Gly Ile  Ile Lys Glu Gly Arg  Xaa Ile Leu 
    1595                 1600                 1605             


Pro Lys  Asp Glu Xaa Glu Lys  Lys Val Leu Xaa Val  Ser Asn Ser 
    1610                 1615                 1620             


Gln Ile  Glu Xaa Glu Ile Glu  Val Pro Ser Ser Ala  Val Pro Glu 
    1625                 1630                 1635             


His Arg  Met Tyr Glu Asn Gln  Ser Gln Val Val Leu  Val Glu Asn 
    1640                 1645                 1650             


Leu His  Val Asn Lys Xaa Asn  Glu Xaa Ile Arg His  Glu Asn Lys 
    1655                 1660                 1665             


Pro Tyr  Val Pro Ser Ser Ala  Gln Met Xaa Arg Arg  Lys Phe Gln 
    1670                 1675                 1680             


Lys Ala  Lys Pro Asn Leu Gly  Arg Ala His Ser Lys  Lys Glu Glu 
    1685                 1690                 1695             


Pro Val  Leu Glu Lys Val Xaa  Xaa Asp Gln Ser Lys  Glu Gly Lys 
    1700                 1705                 1710             


Pro Glu  Asp His Leu Leu Gln  Lys Gly Ala Ser Asn  Xaa Gln Leu 
    1715                 1720                 1725             


Leu Leu  Lys Glu Lys Ala Glu  Leu Leu Xaa Ser Leu  Glu Val Ser 
    1730                 1735                 1740             


Ala Arg  Lys Asp Cys Val Gly  Ser Lys Glu Ser Ala  Leu Ala Lys 
    1745                 1750                 1755             


Ile Asp  Ala Glu Leu Glu Glu  Val Gly Pro Ser Arg  Arg Val Gly 
    1760                 1765                 1770             


Glu Glu  Xaa Val Gly Asp Asn  Ser Pro Ser Ser Val  Val Glu Glu 
    1775                 1780                 1785             


Gln Tyr  Leu Asn Lys Leu Xaa  Ser Cys Pro Gln Pro  Leu Asn Glu 
    1790                 1795                 1800             


Xaa Ser  Tyr Ser Lys Ile Ala  Leu Asp Gly Lys Xaa  Xaa Ile Ser 
    1805                 1810                 1815             


Ser Xaa  Ser Glu Tyr Glu Arg  Asn Arg Gly Glu Arg  Arg Ser His 
    1820                 1825                 1830             


Lys Lys  Phe Lys Pro Asn Val  Xaa Arg Gly Arg Gly  Ser Lys Arg 
    1835                 1840                 1845             


Val Arg  Gly Lys Xaa Ser Lys  Lys Glu Pro Arg Ala  Ser Lys Ala 
    1850                 1855                 1860             


Met Leu  Val Xaa Leu Arg Ala  Ser Gln Glu Glu Asp  Asp Asp Ala 
    1865                 1870                 1875             


Asp Asp  Phe Glu Ser Asp Tyr  Glu Glu Glu Ser Tyr  His Leu Ala 
    1880                 1885                 1890             


Pro Glu  Glu Val Asn Lys Ala  Pro Val Phe Val Pro  Val Gly Leu 
    1895                 1900                 1905             


Arg Ser  Pro Glu Pro Val Ser  Ala Gln Ile Glu Glu  Xaa Met Glu 
    1910                 1915                 1920             


Glu Leu  Glu Ile Xaa Val Asn  Val Pro Asp Val Gly  Cys Ile Ala 
    1925                 1930                 1935             


Val Val  Glu His Glu Leu Pro  Asn Xaa Asp Val Xaa  Xaa Glu Glu 
    1940                 1945                 1950             


Met Lys  Gln Glu Glu Asn Leu  Ser Val Pro Phe Glu  Met Xaa Xaa 
    1955                 1960                 1965             


Ser Glu  His Ile Gln Asp Glu  Pro Gly Xaa Asn Asp  Gly Ser Xaa 
    1970                 1975                 1980             


Glu Ala  Ala Ile Xaa Leu Leu  Xaa Met Gly Asp Leu  Val Leu Gln 
    1985                 1990                 1995             


Ser Glu  Ile Ser Ser Glu Gln  Gly Asp Val Gly Val  Cys Ile Ile 
    2000                 2005                 2010             


Pro His  Val His Ser Lys Asp  Lys Ser His Ile Pro  Ser Ser Leu 
    2015                 2020                 2025             


Asp Asn  Val Asn His Lys Ile  Val His Glu Cys Gln  Glu Leu Ser 
    2030                 2035                 2040             


Ser Pro  Val Ile Xaa Xaa Ser  Pro Ala Ser Phe Glu  Glu Asn Lys 
    2045                 2050                 2055             


Ile Val  Leu Glu Glu Gln Ser  Ser Arg Glu Glu Ile  Ser Leu Met 
    2060                 2065                 2070             


Glu Lys  Val Lys Glu Asn Ala  Xaa Pro Xaa Arg Asn  Xaa Ile Ser 
    2075                 2080                 2085             


Lys Val  Xaa Ser Asn Leu Arg  Ile Arg Ser Arg Leu  Ala Lys Pro 
    2090                 2095                 2100             


Lys Pro  Asn Leu Glu Lys Xaa  Leu Gly Xaa Asn Arg  Leu Asp Asp 
    2105                 2110                 2115             


Tyr Gln  Glu Val Ser Ser Leu  Cys Val Xaa Lys Gly  Ala Glu Met 
    2120                 2125                 2130             


Glu Xaa  Gln Arg Glu Xaa Glu  Lys Asn Ala Ser Lys  Ala Xaa Glu 
    2135                 2140                 2145             


Leu Glu  Asn Lys Asn Leu Gly  Pro Val Xaa Xaa Ala  Glu Asn Lys 
    2150                 2155                 2160             


Asp Gln  Ser Lys Leu Ala Cys  Val His Gly Ile Lys  Gly Xaa Ser 
    2165                 2170                 2175             


Ile Ser  Ser Glu Val Asn Leu  Xaa Glu Arg Asn Glu  Asn Gln Glu 
    2180                 2185                 2190             


Glu Ser  Ser Gln Glu Val His  Met Leu Ser Val Ala  Pro Val Ala 
    2195                 2200                 2205             


Ser Ser  Glu Xaa Gly Pro Cys  Xaa Leu Gly Leu Asp  Arg Gly Leu 
    2210                 2215                 2220             


Gly Glu  Asn Ser Val Glu Glu  Pro Gln Ile Lys Asp  Ser Lys Gly 
    2225                 2230                 2235             


Asp Ser  Val Leu Xaa Leu Pro  Val Pro Glu Tyr Xaa  Pro Xaa Ser 
    2240                 2245                 2250             


Ile Pro  Glu Val Gln Gln Glu  Asn Ile Ile Asn Pro  Gln Asp Leu 
    2255                 2260                 2265             


Xaa Val  Asn Leu Val Ala Asn  Val Pro Gln Asp Gly  Glu Asp Glu 
    2270                 2275                 2280             


Gln Ala  Phe Ile Leu Xaa Leu  Val Glu Ile Pro Ala  Asn Ala Val 
    2285                 2290                 2295             


Glu Glu  Phe Xaa Asp Ala Xaa  Ala Gln Phe Met Pro  Asn Pro Leu 
    2300                 2305                 2310             


Leu Pro  Ala Pro Ile Leu Val  Lys Ser Val Asn Xaa  Glu Glu Arg 
    2315                 2320                 2325             


Gly Asp  Met Ser Ile Cys Leu  Pro Ala Xaa Ser Val  Gly Gln Asp 
    2330                 2335                 2340             


Ala Met  Gly Leu Ser Ile Ser  Gly Arg Asp Asn Ser  Lys Lys Pro 
    2345                 2350                 2355             


Pro Asp  Asn Leu Asp Leu Val  Ser Arg Lys Arg Phe  Gln Cys Arg 
    2360                 2365                 2370             


Leu Asp  Lys Asn Asp His Ile  Pro Pro Ala Lys Lys  Arg Ser Leu 
    2375                 2380                 2385             


Xaa Leu  Arg Asp Asp Cys Gln  Glu Tyr Xaa Xaa Glu  Val His Ser 
    2390                 2395                 2400             


Lys Glu  Leu Xaa Asn Val Phe  Glu Glu Xaa Gly Glu  Ser His Lys 
    2405                 2410                 2415             


Gly Gln  Asp Ile Phe Leu Xaa  Ser Gly Ser Xaa Leu  Xaa Xaa Pro 
    2420                 2425                 2430             


Glu Pro  Gln Arg Gln Gln Val  Glu Ala Ala Phe Gln  Ser Arg Gly 
    2435                 2440                 2445             


Ser Arg  Ser Pro Asp Ala Cys  Met Asp Lys Asn Val  Pro Gln Leu 
    2450                 2455                 2460             


Pro Gln  Asp Glu Met Ile Val  Ser Asp Lys Glu Glu  Arg Xaa Asp 
    2465                 2470                 2475             


Ala Ala  Pro Lys Ser Gln Gln  Met Asp Ser Arg Xaa  Ser Ser Ser 
    2480                 2485                 2490             


Lys Ala  Ser Leu Ser Arg Pro  Gly Arg Arg Pro Leu  Gly Phe Leu 
    2495                 2500                 2505             


Ser Leu  Ile Cys Ser Lys Asn  Ser Leu Glu Ser Asp  Glu Pro Met 
    2510                 2515                 2520             


Gln Val  His Ser Lys Lys Arg  Leu Lys Pro Leu Ile  Pro Gly Leu 
    2525                 2530                 2535             


Arg Lys  Lys Leu Lys Arg Ser  Asn Pro Phe Asn Glu  Ser Gln Glu 
    2540                 2545                 2550             


Lys Asn  Arg Glu Ser Ser Asp  Leu Leu Pro Ser Pro  Ser Val Ile 
    2555                 2560                 2565             


Xaa Xaa  Gln Ser Glu Asn Ile  Ser Ser Ser Ala Xaa  Gln Val Ser 
    2570                 2575                 2580             


Cys Asp  Gln Pro Leu Leu Lys  Glu Gly Tyr Lys Ser  Ala Gln Lys 
    2585                 2590                 2595             


Arg Ala  Pro Gln Gly Glu Ala  Xaa Xaa Val Ser Glu  Tyr Phe Phe 
    2600                 2605                 2610             


Asn Asp  Ile Phe Ile Glu Val  Asp Glu Xaa Glu 
    2615                 2620                 


<210> 4156
<211> 846
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<400> 4156
Met Phe Arg Arg Ala Arg Leu Ser Val Lys Pro Asn Val Arg Pro Gly 
1               5                   10                  15      


Val Gly Ala Arg Gly Ser Xaa Ala Ser Asn Pro Gln Arg Gly Arg Glu 
            20                  25                  30          


Ser Pro Arg Pro Pro Glu Pro Ala Xaa Asp Ser Ala Ser Lys Pro Ala 
        35                  40                  45              


Glu Pro Xaa Asp Val Pro Xaa Val Asp Phe Gly Gly Ala Glu Pro Gln 
    50                  55                  60                  


Glu Lys Ala Pro Arg Ser Ser Xaa Glu Lys Xaa Gly Gly Asp Asn Asp 
65                  70                  75                  80  


Val Glu Glu Ser Ser Arg Ser Ser Ser Xaa Val Ser Gln Arg Arg Lys 
                85                  90                  95      


Arg Ile Ser Ser Xaa Ser Ser Leu Val Lys Ser Ser Val Ser Val Pro 
            100                 105                 110         


Ser Glu Ser His Pro Leu Ser Xaa Ile Asn Gln Glu Ala Pro Gln Pro 
        115                 120                 125             


Xaa Ala Xaa Ser Xaa Lys Glu Lys Gln Pro Cys Ser Asp Arg Tyr Arg 
    130                 135                 140                 


Ile Tyr Lys Ala Gln Lys Leu Arg Glu Met Leu Lys Glu Glu Leu Arg 
145                 150                 155                 160 


Lys Glu Lys Lys Gln Trp Lys Asn Lys Tyr Ala Ile Asn Glu Ser Gln 
                165                 170                 175     


Arg Pro Pro Asp Arg Ser Lys Met Xaa Met Arg Asp Phe Ile Tyr Tyr 
            180                 185                 190         


Leu Pro Asp Asn Asn Pro Met Xaa Ser Ser Leu Glu Gln Glu Lys Lys 
        195                 200                 205             


Xaa Glu Lys Pro Ser Xaa Pro Val Gln Xaa Arg Glu Gln Glu Gly Lys 
    210                 215                 220                 


Ser Xaa Pro Asn Ala Glu Asp Asn Glu Met Glu Glu Glu Xaa Asp Asp 
225                 230                 235                 240 


Gly Pro Leu Leu Val Pro Arg Val Lys Val Ala Glu Asp Gly Ser Ile 
                245                 250                 255     


Ile Leu Asp Glu Glu Ser Leu Xaa Val Glu Val Leu Arg Xaa Lys Gly 
            260                 265                 270         


Pro Cys Val Val Glu Glu Asn Asp Pro Ile Phe Glu Arg Gly Ser Xaa 
        275                 280                 285             


Xaa Xaa Tyr Ser Ser Phe Arg Lys Asn Tyr Tyr Ser Lys Pro Trp Ser 
    290                 295                 300                 


Asn Lys Glu Xaa Asp Met Phe Phe Leu Ala Ile Ser Met Val Gly Xaa 
305                 310                 315                 320 


Asp Phe Ser Met Ile Gly Gln Leu Phe Pro His Arg Ala Arg Ile Glu 
                325                 330                 335     


Ile Lys Asn Lys Phe Lys Arg Glu Glu Lys Xaa Asn Gly Trp Arg Ile 
            340                 345                 350         


Asp Lys Ala Phe Gln Glu Lys Arg Pro Phe Asp Phe Asp Phe Phe Ala 
        355                 360                 365             


His Leu Leu Gln Lys Val Leu Ala Glu Glu Glu Lys Arg Lys Gln Lys 
    370                 375                 380                 


Ser Val Lys Asn His Ser Leu Lys Glu Lys Lys Ser Xaa Lys Pro Arg 
385                 390                 395                 400 


Lys Asn Val Lys Val Lys Lys Val Ala Cys Glu Gly Val Asn Asn Asp 
                405                 410                 415     


Pro Asp Glu Ser Met Ser Ser Arg Ile Ser Asp Xaa Glu Arg Ser Gln 
            420                 425                 430         


Lys Asp Ala Gln Xaa Val Glu Glu Glu Ser Leu Xaa Leu Ser Arg Glu 
        435                 440                 445             


Asp Ala Glu Gln Val Ala Leu Glu Val Asp Leu Asn Gln Lys Lys Arg 
    450                 455                 460                 


Arg Arg Lys Lys Gln Asp Gly Ala Asn Glu Leu Gly Val Asn Asn Leu 
465                 470                 475                 480 


Leu Glu Asn Ala Xaa Val Gln Ala Gly Pro Ser Lys Gly Glu Lys His 
                485                 490                 495     


Lys Asn Lys Cys Gln Ala Ile Arg Pro Glu Leu Lys Glu Gly Glu Cys 
            500                 505                 510         


Ser Lys Glu Gln Met Leu Ser Cys Xaa Gln Asn Ile Asp Gly Ile Val 
        515                 520                 525             


Gly Phe Ala Ser Xaa Glu Lys Val Glu Lys Arg Xaa Asp Pro Ile Leu 
    530                 535                 540                 


Ser Leu Ser Asn Gln Gln Asp Ala Xaa Ser Val Ala Xaa Glu Ser Ser 
545                 550                 555                 560 


Glu Ser Ser Xaa Ser Asp Leu Pro Ser Phe Glu Val Gly Ile Arg Ala 
                565                 570                 575     


Leu Cys Glu Val Asn Asn Ala Glu Gly Ser Cys Ile Glu Glu Arg Asn 
            580                 585                 590         


Val Asp Leu Lys Asn Asn Ser Leu Glu Ile Asp Gln Xaa Glu Asn Val 
        595                 600                 605             


Lys Pro Met Leu Arg Gly Arg Phe Gln Arg Pro Lys Pro Asn Leu Ser 
    610                 615                 620                 


Arg Ala Gly Lys Lys Ser Val Leu Ser Gln Gly Lys Xaa Glu Ser Glu 
625                 630                 635                 640 


Ser Lys Asn Ser His Ser Lys Xaa Ser Val Glu Lys Asn His Val Glu 
                645                 650                 655     


Lys Asp Lys Met Asn Xaa Leu Asp Ile Leu Arg Met Glu Xaa Xaa Glu 
            660                 665                 670         


Arg Glu Asn Pro Glu Ala Glu Xaa Val Ser Val Leu Gly Glu Lys Asn 
        675                 680                 685             


Cys Leu Gln Glu Gly Ser Gln Leu Lys Ala Leu Arg Pro Val Gln Val 
    690                 695                 700                 


Arg Gly Arg Leu Gln Lys Pro Lys Pro Asn Ala Gly Lys Ala Ala Glu 
705                 710                 715                 720 


Arg Lys Glu Ile Leu Ile Ser Gln Glu Glu Ile Gly Ala Asn Val Glu 
                725                 730                 735     


Lys Asn Glu Asn Glu Ser Cys Ala Asp Arg Asp Xaa Pro Gln His Met 
            740                 745                 750         


Glu Asp Gln Ser Arg Lys Asp Phe Glu Glu Glu Asp Val Ile Leu Gln 
        755                 760                 765             


Pro Glu Lys Asn Asp Ser Phe Gln Asn Val Gln Pro Asp Glu Pro Lys 
    770                 775                 780                 


Val Leu Asn Glu Cys Leu Ser Val Gln Glu Asn Asn Lys Ala Asn Lys 
785                 790                 795                 800 


Leu Asn Gln Val Pro Ile Leu Arg Xaa Arg Phe Gln Lys Pro Lys Pro 
                805                 810                 815     


Asn Ile Gly Arg Gly Xaa Gly Arg Arg Glu Ile Ser Ser Lys Glu Glu 
            820                 825                 830         


Val Leu Glu Lys Ile Leu Ser Leu Gly Lys Trp Arg Gln His 
        835                 840                 845     


<210> 4157
<211> 2624
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1131)..(1131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1138)..(1138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1314)..(1314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1328)..(1328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1365)..(1365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1396)..(1396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1454)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1485)..(1485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1503)..(1503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1517)..(1517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1551)..(1551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1556)..(1556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1613)..(1613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1619)..(1619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1627)..(1627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1659)..(1659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1662)..(1662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1678)..(1678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1705)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1726)..(1726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1738)..(1738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1776)..(1776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1795)..(1795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1804)..(1804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1815)..(1816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1820)..(1820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1841)..(1841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1853)..(1853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1867)..(1867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1921)..(1921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1928)..(1928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1947)..(1947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1950)..(1951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1967)..(1968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1978)..(1978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1983)..(1983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1988)..(1988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1991)..(1991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2048)..(2049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2081)..(2081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2083)..(2083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2086)..(2086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2091)..(2091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2110)..(2110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2113)..(2113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2128)..(2128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2135)..(2135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2139)..(2139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2147)..(2147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2158)..(2159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2177)..(2177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2186)..(2186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2212)..(2212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2216)..(2216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2243)..(2243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2250)..(2250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2252)..(2252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2269)..(2269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2289)..(2289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2302)..(2302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2305)..(2305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2325)..(2325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2338)..(2338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2389)..(2389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2398)..(2399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2407)..(2407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2413)..(2413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2425)..(2425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2429)..(2429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2431)..(2432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2477)..(2477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2490)..(2490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2569)..(2570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2580)..(2580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2606)..(2607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2623)..(2623)
<223> Selenocysteine

<400> 4157
Met Phe Arg Arg Ala Arg Leu Ser Val Lys Pro Asn Val Arg Pro Gly 
1               5                   10                  15      


Val Gly Ala Arg Gly Ser Xaa Ala Ser Asn Pro Gln Arg Gly Arg Glu 
            20                  25                  30          


Ser Pro Arg Pro Pro Glu Pro Ala Xaa Asp Ser Ala Ser Lys Pro Ala 
        35                  40                  45              


Glu Pro Xaa Asp Val Pro Xaa Val Asp Phe Gly Gly Ala Glu Pro Gln 
    50                  55                  60                  


Glu Lys Ala Pro Arg Ser Ser Xaa Glu Lys Xaa Gly Gly Asp Asn Asp 
65                  70                  75                  80  


Val Glu Glu Ser Ser Arg Ser Ser Ser Xaa Val Ser Gln Arg Arg Lys 
                85                  90                  95      


Arg Ile Ser Ser Xaa Ser Ser Leu Val Lys Ser Ser Val Ser Val Pro 
            100                 105                 110         


Ser Glu Ser His Pro Leu Ser Xaa Ile Asn Gln Glu Ala Pro Gln Pro 
        115                 120                 125             


Xaa Ala Xaa Ser Xaa Lys Glu Lys Gln Pro Cys Ser Asp Arg Tyr Arg 
    130                 135                 140                 


Ile Tyr Lys Ala Gln Lys Leu Arg Glu Met Leu Lys Glu Glu Leu Arg 
145                 150                 155                 160 


Lys Glu Lys Lys Gln Trp Lys Asn Lys Tyr Ala Ile Asn Glu Ser Gln 
                165                 170                 175     


Arg Pro Pro Asp Arg Ser Lys Met Xaa Met Arg Asp Phe Ile Tyr Tyr 
            180                 185                 190         


Leu Pro Asp Asn Asn Pro Met Xaa Ser Ser Leu Glu Gln Glu Lys Lys 
        195                 200                 205             


Xaa Glu Lys Pro Ser Xaa Pro Val Gln Xaa Arg Glu Gln Glu Gly Lys 
    210                 215                 220                 


Ser Xaa Pro Asn Ala Glu Asp Asn Glu Met Glu Glu Glu Xaa Asp Asp 
225                 230                 235                 240 


Gly Pro Leu Leu Val Pro Arg Val Lys Val Ala Glu Asp Gly Ser Ile 
                245                 250                 255     


Ile Leu Asp Glu Glu Ser Leu Xaa Val Glu Val Leu Arg Xaa Lys Gly 
            260                 265                 270         


Pro Cys Val Val Glu Glu Asn Asp Pro Ile Phe Glu Arg Gly Ser Xaa 
        275                 280                 285             


Xaa Xaa Tyr Ser Ser Phe Arg Lys Asn Tyr Tyr Ser Lys Pro Trp Ser 
    290                 295                 300                 


Asn Lys Glu Xaa Asp Met Phe Phe Leu Ala Ile Ser Met Val Gly Xaa 
305                 310                 315                 320 


Asp Phe Ser Met Ile Gly Gln Leu Phe Pro His Arg Ala Arg Ile Glu 
                325                 330                 335     


Ile Lys Asn Lys Phe Lys Arg Glu Glu Lys Xaa Asn Gly Trp Arg Ile 
            340                 345                 350         


Asp Lys Ala Phe Gln Glu Lys Arg Pro Phe Asp Phe Asp Phe Phe Ala 
        355                 360                 365             


His Leu Leu Gln Lys Val Leu Ala Glu Glu Glu Lys Arg Lys Gln Lys 
    370                 375                 380                 


Ser Val Lys Asn His Ser Leu Lys Glu Lys Lys Ser Xaa Lys Pro Arg 
385                 390                 395                 400 


Lys Asn Val Lys Val Lys Lys Val Ala Cys Glu Gly Val Asn Asn Asp 
                405                 410                 415     


Pro Asp Glu Ser Met Ser Ser Arg Ile Ser Asp Xaa Glu Arg Ser Gln 
            420                 425                 430         


Lys Asp Ala Gln Xaa Val Glu Glu Glu Ser Leu Xaa Leu Ser Arg Glu 
        435                 440                 445             


Asp Ala Glu Gln Val Ala Leu Glu Val Asp Leu Asn Gln Lys Lys Arg 
    450                 455                 460                 


Arg Arg Lys Lys Gln Asp Gly Ala Asn Glu Leu Gly Val Asn Asn Leu 
465                 470                 475                 480 


Leu Glu Asn Ala Xaa Val Gln Ala Gly Pro Ser Lys Gly Glu Lys His 
                485                 490                 495     


Lys Asn Lys Cys Gln Ala Ile Arg Pro Glu Leu Lys Glu Gly Glu Cys 
            500                 505                 510         


Ser Lys Glu Gln Met Leu Ser Cys Xaa Gln Asn Ile Asp Gly Ile Val 
        515                 520                 525             


Gly Phe Ala Ser Xaa Glu Lys Val Glu Lys Arg Xaa Asp Pro Ile Leu 
    530                 535                 540                 


Ser Leu Ser Asn Gln Gln Asp Ala Xaa Ser Val Ala Xaa Glu Ser Ser 
545                 550                 555                 560 


Glu Ser Ser Xaa Ser Asp Leu Pro Ser Phe Glu Val Gly Ile Arg Ala 
                565                 570                 575     


Leu Cys Glu Val Asn Asn Ala Glu Gly Ser Cys Ile Glu Glu Arg Asn 
            580                 585                 590         


Val Asp Leu Lys Asn Asn Ser Leu Glu Ile Asp Gln Xaa Glu Asn Val 
        595                 600                 605             


Lys Pro Met Leu Arg Gly Arg Phe Gln Arg Pro Lys Pro Asn Leu Ser 
    610                 615                 620                 


Arg Ala Gly Lys Lys Ser Val Leu Ser Gln Gly Lys Xaa Glu Ser Glu 
625                 630                 635                 640 


Ser Lys Asn Ser His Ser Lys Xaa Ser Val Glu Lys Asn His Val Glu 
                645                 650                 655     


Lys Asp Lys Met Asn Xaa Leu Asp Ile Leu Arg Met Glu Xaa Xaa Glu 
            660                 665                 670         


Arg Glu Asn Pro Glu Ala Glu Xaa Val Ser Val Leu Gly Glu Lys Asn 
        675                 680                 685             


Cys Leu Gln Glu Gly Ser Gln Leu Lys Ala Leu Arg Pro Val Gln Val 
    690                 695                 700                 


Arg Gly Arg Leu Gln Lys Pro Lys Pro Asn Ala Gly Lys Ala Ala Glu 
705                 710                 715                 720 


Arg Lys Glu Ile Leu Ile Ser Gln Glu Glu Ile Gly Ala Asn Val Glu 
                725                 730                 735     


Lys Asn Glu Asn Glu Ser Cys Ala Asp Arg Asp Xaa Pro Gln His Met 
            740                 745                 750         


Glu Asp Gln Ser Arg Lys Asp Phe Glu Glu Glu Asp Val Ile Leu Gln 
        755                 760                 765             


Pro Glu Lys Asn Asp Ser Phe Gln Asn Val Gln Pro Asp Glu Pro Lys 
    770                 775                 780                 


Val Leu Asn Glu Cys Leu Ser Val Gln Glu Asn Asn Lys Ala Asn Lys 
785                 790                 795                 800 


Leu Asn Gln Val Pro Ile Leu Arg Xaa Arg Phe Gln Lys Pro Lys Pro 
                805                 810                 815     


Asn Ile Gly Arg Gly Xaa Gly Arg Arg Glu Ile Ser Ser Lys Glu Glu 
            820                 825                 830         


Val Leu Glu Lys Ile Leu Val Ser Gly Glu Met Ala Ala Ala Leu Arg 
        835                 840                 845             


Glu Xaa Val Arg Leu Asp Xaa Ser Pro Lys Glu Met Val Pro Ala Glu 
    850                 855                 860                 


Ile Asn Xaa Lys Glu Met Gln Ser Asp Leu Lys Glu Xaa Gly Arg Arg 
865                 870                 875                 880 


Ala Ile Ser Pro Arg Glu Lys Ile Leu Asp Val Ile Asp Asp Xaa Ile 
                885                 890                 895     


Glu Met Glu Xaa Gly Leu Lys Ala Met Gly Arg Glu Ile Cys Leu Arg 
            900                 905                 910         


Glu Lys Xaa Pro Glu Val Ile Asp Ala Xaa Glu Glu Ile Asp Lys Asp 
        915                 920                 925             


Leu Glu Glu Ala Gly Arg Arg Glu Ile Ser Pro Gln Lys Asn Gly Pro 
    930                 935                 940                 


Glu Glu Val Lys Pro Leu Gly Glu Val Glu Xaa Asp Leu Lys Ala Xaa 
945                 950                 955                 960 


Gly Asn Glu Ser Ser Pro Arg Glu Lys Xaa Pro Glu Val Xaa Asp Ala 
                965                 970                 975     


Xaa Glu Glu Ile Asp Lys Asn Leu Glu Glu Xaa Gly Arg Arg Lys Ile 
            980                 985                 990         


Ser Pro Arg Glu Asn Gly Pro Glu  Glu Val Lys Pro Val  Asp Glu Met 
        995                 1000                 1005             


Glu Xaa  Asp Leu Asn Ala Xaa  Gly Arg Glu Ser Ser  Pro Arg Glu 
    1010                 1015                 1020             


Lys Xaa  Pro Glu Val Ile Asp  Ala Xaa Glu Glu Ile  Asp Leu Glu 
    1025                 1030                 1035             


Glu Xaa  Glu Arg Glu Val Ser  Pro Gln Glu Asn Gly  Leu Glu Glu 
    1040                 1045                 1050             


Val Lys  Pro Leu Gly Glu Met  Glu Xaa Asp Leu Lys  Ala Xaa Gly 
    1055                 1060                 1065             


Arg Asp  Ser Phe Pro Arg Gly  Lys Xaa Pro Glu Val  Ile Asp Ala 
    1070                 1075                 1080             


Ile Glu  Glu Ile Glu Ile Asp  Leu Glu Glu Xaa Glu  Arg Glu Ile 
    1085                 1090                 1095             


Ser Pro  Gln Glu Asn Gly Leu  Glu Glu Val Lys Pro  Leu Gly Glu 
    1100                 1105                 1110             


Met Gln  Xaa Asp Leu Lys Ala  Xaa Gly Arg Glu Ile  Ser Pro Arg 
    1115                 1120                 1125             


Glu Lys  Xaa Pro Glu Val Ile  Asp Ala Xaa Glu Glu  Ile Asp Lys 
    1130                 1135                 1140             


Asp Leu  Glu Glu Xaa Gly Arg  Arg Glu Ile Ser Pro  Glu Glu Asn 
    1145                 1150                 1155             


Gly Pro  Glu Glu Val Lys Pro  Val Asp Glu Met Glu  Xaa Asp Leu 
    1160                 1165                 1170             


Lys Xaa  Xaa Gly Arg Glu Gly  Ser Ser Arg Glu Lys  Xaa Arg Glu 
    1175                 1180                 1185             


Val Ile  Asp Ala Ala Glu Val  Ile Glu Xaa Asp Leu  Glu Glu Xaa 
    1190                 1195                 1200             


Glu Arg  Glu Ile Ser Pro Gln  Glu Asn Gly Pro Glu  Glu Val Lys 
    1205                 1210                 1215             


Pro Val  Gly Lys Met Glu Xaa  Asp Leu Lys Glu Ile  Arg Glu Glu 
    1220                 1225                 1230             


Ile Ser  Gln Arg Glu Lys Val  Leu Ala Glu Phe Ser  Ala Ile Arg 
    1235                 1240                 1245             


Glu Lys  Glu Ile Asp Leu Lys  Glu Xaa Gly Lys Arg  Asp Ile Pro 
    1250                 1255                 1260             


Ile Met  Glu Lys Val Ser Gly  Lys Met Ala Val Val  Glu Glu Met 
    1265                 1270                 1275             


Glu Ala  Asp Leu Lys Glu Xaa  Gly Lys Glu Asn Phe  Arg Glu Arg 
    1280                 1285                 1290             


Gly Ser  Glu Glu Ile Cys Val  Xaa Glu Glu Lys Val  Ala Glu Leu 
    1295                 1300                 1305             


Lys Gln  Xaa Gly Lys Xaa Asp  Ile Ser Pro Arg Glu  Asn Glu Leu 
    1310                 1315                 1320             


Glu Glu  Xaa Ser Xaa Ser Arg  Gln Xaa Asp Xaa His  Leu Met Gln 
    1325                 1330                 1335             


Ser Gly  Ser Asn Asp Phe Ser  Ala Val Pro Ser Leu  Asp Ile Gln 
    1340                 1345                 1350             


Asn Ile  Ser Ser Glu Val Leu  Ser Met Met His Xaa  Pro Val Glu 
    1355                 1360                 1365             


Glu Lys  Arg Asn Ser Glu Lys  Glu Val Ser Ser His  Phe Ser His 
    1370                 1375                 1380             


Phe Lys  Ile Ser Ser Gln Xaa  His Glu Ser Asp Lys  Xaa Glu Val 
    1385                 1390                 1395             


Gln Gly  Ile Gln Ser Pro Asp  Val Pro Glu Gln Phe  Ser Asp Ile 
    1400                 1405                 1410             


Asn Leu  Ser Lys Ser Leu Pro  Gln Glu Gln Lys Pro  Leu Glu Ile 
    1415                 1420                 1425             


Lys Pro  Ala Pro Phe Val Arg  Ser Arg Phe Lys Arg  Pro Lys Pro 
    1430                 1435                 1440             


Asn Leu  Ala Arg Ala Ala Leu  Lys Arg Glu Xaa Xaa  Glu Ser Glu 
    1445                 1450                 1455             


Lys Tyr  Ile Tyr Glu Lys Lys  Ser Glu Xaa Lys Lys  Met Glu Xaa 
    1460                 1465                 1470             


Ile Val  Met Gln Glu Asn Asn  Glu Gln Xaa Asp Xaa  Leu Pro Ser 
    1475                 1480                 1485             


Gln His  Asp Glu Ala Ser Leu  Met Ile Ser Arg Glu  Lys Asp Xaa 
    1490                 1495                 1500             


Leu Gly  His Arg Asn Glu Glu  Ala Val Ile Leu Pro  Cys Xaa Gln 
    1505                 1510                 1515             


Xaa Glu  Arg Asn Leu Ser Pro  Ser Asn Ser Cys Glu  Pro Lys Glu 
    1520                 1525                 1530             


Glu Ser  Gln Ser Ala Pro Val  Gln Lys Asn Asp Ser  Val Val Ser 
    1535                 1540                 1545             


Val Gly  Xaa Asn Asn Val Asn  Xaa Phe Gln Gln Glu  Met Lys Glu 
    1550                 1555                 1560             


Ser Val  Ile Gln Xaa Ala Arg  Gln Val Arg Gly Arg  Leu Gln Arg 
    1565                 1570                 1575             


Pro Arg  Pro Asn Ile Arg Lys  Xaa Gly Gln Arg Gln  Ile Val Asp 
    1580                 1585                 1590             


Lys Gly  Glu Ala Lys Gly Ile  Ile Lys Glu Gly Arg  Xaa Ile Leu 
    1595                 1600                 1605             


Pro Lys  Asp Glu Xaa Glu Lys  Lys Val Leu Xaa Val  Ser Asn Ser 
    1610                 1615                 1620             


Gln Ile  Glu Xaa Glu Ile Glu  Val Pro Ser Ser Ala  Val Pro Glu 
    1625                 1630                 1635             


His Arg  Met Tyr Glu Asn Gln  Ser Gln Val Val Leu  Val Glu Asn 
    1640                 1645                 1650             


Leu His  Val Asn Lys Xaa Asn  Glu Xaa Ile Arg His  Glu Asn Lys 
    1655                 1660                 1665             


Pro Tyr  Val Pro Ser Ser Ala  Gln Met Xaa Arg Arg  Lys Phe Gln 
    1670                 1675                 1680             


Lys Ala  Lys Pro Asn Leu Gly  Arg Ala His Ser Lys  Lys Glu Glu 
    1685                 1690                 1695             


Pro Val  Leu Glu Lys Val Xaa  Xaa Asp Gln Ser Lys  Glu Gly Lys 
    1700                 1705                 1710             


Pro Glu  Asp His Leu Leu Gln  Lys Gly Ala Ser Asn  Xaa Gln Leu 
    1715                 1720                 1725             


Leu Leu  Lys Glu Lys Ala Glu  Leu Leu Xaa Ser Leu  Glu Val Ser 
    1730                 1735                 1740             


Ala Arg  Lys Asp Cys Val Gly  Ser Lys Glu Ser Ala  Leu Ala Lys 
    1745                 1750                 1755             


Ile Asp  Ala Glu Leu Glu Glu  Val Gly Pro Ser Arg  Arg Val Gly 
    1760                 1765                 1770             


Glu Glu  Xaa Val Gly Asp Asn  Ser Pro Ser Ser Val  Val Glu Glu 
    1775                 1780                 1785             


Gln Tyr  Leu Asn Lys Leu Xaa  Ser Cys Pro Gln Pro  Leu Asn Glu 
    1790                 1795                 1800             


Xaa Ser  Tyr Ser Lys Ile Ala  Leu Asp Gly Lys Xaa  Xaa Ile Ser 
    1805                 1810                 1815             


Ser Xaa  Ser Glu Tyr Glu Arg  Asn Arg Gly Glu Arg  Arg Ser His 
    1820                 1825                 1830             


Lys Lys  Phe Lys Pro Asn Val  Xaa Arg Gly Arg Gly  Ser Lys Arg 
    1835                 1840                 1845             


Val Arg  Gly Lys Xaa Ser Lys  Lys Glu Pro Arg Ala  Ser Lys Ala 
    1850                 1855                 1860             


Met Leu  Val Xaa Leu Arg Ala  Ser Gln Glu Glu Asp  Asp Asp Ala 
    1865                 1870                 1875             


Asp Asp  Phe Glu Ser Asp Tyr  Glu Glu Glu Ser Tyr  His Leu Ala 
    1880                 1885                 1890             


Pro Glu  Glu Val Asn Lys Ala  Pro Val Phe Val Pro  Val Gly Leu 
    1895                 1900                 1905             


Arg Ser  Pro Glu Pro Val Ser  Ala Gln Ile Glu Glu  Xaa Met Glu 
    1910                 1915                 1920             


Glu Leu  Glu Ile Xaa Val Asn  Val Pro Asp Val Gly  Cys Ile Ala 
    1925                 1930                 1935             


Val Val  Glu His Glu Leu Pro  Asn Xaa Asp Val Xaa  Xaa Glu Glu 
    1940                 1945                 1950             


Met Lys  Gln Glu Glu Asn Leu  Ser Val Pro Phe Glu  Met Xaa Xaa 
    1955                 1960                 1965             


Ser Glu  His Ile Gln Asp Glu  Pro Gly Xaa Asn Asp  Gly Ser Xaa 
    1970                 1975                 1980             


Glu Ala  Ala Ile Xaa Leu Leu  Xaa Met Gly Asp Leu  Val Leu Gln 
    1985                 1990                 1995             


Ser Glu  Ile Ser Ser Glu Gln  Gly Asp Val Gly Val  Cys Ile Ile 
    2000                 2005                 2010             


Pro His  Val His Ser Lys Asp  Lys Ser His Ile Pro  Ser Ser Leu 
    2015                 2020                 2025             


Asp Asn  Val Asn His Lys Ile  Val His Glu Cys Gln  Glu Leu Ser 
    2030                 2035                 2040             


Ser Pro  Val Ile Xaa Xaa Ser  Pro Ala Ser Phe Glu  Glu Asn Lys 
    2045                 2050                 2055             


Ile Val  Leu Glu Glu Gln Ser  Ser Arg Glu Glu Ile  Ser Leu Met 
    2060                 2065                 2070             


Glu Lys  Val Lys Glu Asn Ala  Xaa Pro Xaa Arg Asn  Xaa Ile Ser 
    2075                 2080                 2085             


Lys Val  Xaa Ser Asn Leu Arg  Ile Arg Ser Arg Leu  Ala Lys Pro 
    2090                 2095                 2100             


Lys Pro  Asn Leu Glu Lys Xaa  Leu Gly Xaa Asn Arg  Leu Asp Asp 
    2105                 2110                 2115             


Tyr Gln  Glu Val Ser Ser Leu  Cys Val Xaa Lys Gly  Ala Glu Met 
    2120                 2125                 2130             


Glu Xaa  Gln Arg Glu Xaa Glu  Lys Asn Ala Ser Lys  Ala Xaa Glu 
    2135                 2140                 2145             


Leu Glu  Asn Lys Asn Leu Gly  Pro Val Xaa Xaa Ala  Glu Asn Lys 
    2150                 2155                 2160             


Asp Gln  Ser Lys Leu Ala Cys  Val His Gly Ile Lys  Gly Xaa Ser 
    2165                 2170                 2175             


Ile Ser  Ser Glu Val Asn Leu  Xaa Glu Arg Asn Glu  Asn Gln Glu 
    2180                 2185                 2190             


Glu Ser  Ser Gln Glu Val His  Met Leu Ser Val Ala  Pro Val Ala 
    2195                 2200                 2205             


Ser Ser  Glu Xaa Gly Pro Cys  Xaa Leu Gly Leu Asp  Arg Gly Leu 
    2210                 2215                 2220             


Gly Glu  Asn Ser Val Glu Glu  Pro Gln Ile Lys Asp  Ser Lys Gly 
    2225                 2230                 2235             


Asp Ser  Val Leu Xaa Leu Pro  Val Pro Glu Tyr Xaa  Pro Xaa Ser 
    2240                 2245                 2250             


Ile Pro  Glu Val Gln Gln Glu  Asn Ile Ile Asn Pro  Gln Asp Leu 
    2255                 2260                 2265             


Xaa Val  Asn Leu Val Ala Asn  Val Pro Gln Asp Gly  Glu Asp Glu 
    2270                 2275                 2280             


Gln Ala  Phe Ile Leu Xaa Leu  Val Glu Ile Pro Ala  Asn Ala Val 
    2285                 2290                 2295             


Glu Glu  Phe Xaa Asp Ala Xaa  Ala Gln Phe Met Pro  Asn Pro Leu 
    2300                 2305                 2310             


Leu Pro  Ala Pro Ile Leu Val  Lys Ser Val Asn Xaa  Glu Glu Arg 
    2315                 2320                 2325             


Gly Asp  Met Ser Ile Cys Leu  Pro Ala Xaa Ser Val  Gly Gln Asp 
    2330                 2335                 2340             


Ala Met  Gly Leu Ser Ile Ser  Gly Arg Asp Asn Ser  Lys Lys Pro 
    2345                 2350                 2355             


Pro Asp  Asn Leu Asp Leu Val  Ser Arg Lys Arg Phe  Gln Cys Arg 
    2360                 2365                 2370             


Leu Asp  Lys Asn Asp His Ile  Pro Pro Ala Lys Lys  Arg Ser Leu 
    2375                 2380                 2385             


Xaa Leu  Arg Asp Asp Cys Gln  Glu Tyr Xaa Xaa Glu  Val His Ser 
    2390                 2395                 2400             


Lys Glu  Leu Xaa Asn Val Phe  Glu Glu Xaa Gly Glu  Ser His Lys 
    2405                 2410                 2415             


Gly Gln  Asp Ile Phe Leu Xaa  Ser Gly Ser Xaa Leu  Xaa Xaa Pro 
    2420                 2425                 2430             


Glu Pro  Gln Arg Gln Gln Val  Glu Ala Ala Phe Gln  Ser Arg Gly 
    2435                 2440                 2445             


Ser Arg  Ser Pro Asp Ala Cys  Met Asp Lys Asn Val  Pro Gln Leu 
    2450                 2455                 2460             


Pro Gln  Asp Glu Met Ile Val  Ser Asp Lys Glu Glu  Arg Xaa Asp 
    2465                 2470                 2475             


Ala Ala  Pro Lys Ser Gln Gln  Met Asp Ser Arg Xaa  Ser Ser Ser 
    2480                 2485                 2490             


Lys Ala  Ser Leu Ser Arg Pro  Gly Arg Arg Pro Leu  Gly Phe Leu 
    2495                 2500                 2505             


Ser Leu  Ile Cys Ser Lys Asn  Ser Leu Glu Ser Asp  Glu Pro Met 
    2510                 2515                 2520             


Gln Val  His Ser Lys Lys Arg  Leu Lys Pro Leu Ile  Pro Gly Leu 
    2525                 2530                 2535             


Arg Lys  Lys Leu Lys Arg Ser  Asn Pro Phe Asn Glu  Ser Gln Glu 
    2540                 2545                 2550             


Lys Asn  Arg Glu Ser Ser Asp  Leu Leu Pro Ser Pro  Ser Val Ile 
    2555                 2560                 2565             


Xaa Xaa  Gln Ser Glu Asn Ile  Ser Ser Ser Ala Xaa  Gln Val Ser 
    2570                 2575                 2580             


Cys Asp  Gln Pro Leu Leu Lys  Glu Gly Tyr Lys Ser  Ala Gln Lys 
    2585                 2590                 2595             


Arg Ala  Pro Gln Gly Glu Ala  Xaa Xaa Val Ser Glu  Tyr Phe Phe 
    2600                 2605                 2610             


Asn Asp  Ile Phe Ile Glu Val  Asp Glu Xaa Glu 
    2615                 2620                 


<210> 4158
<211> 606
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<400> 4158
Xaa Asp Val Xaa Xaa Glu Glu Met Lys Gln Glu Glu Asn Leu Ser Val 
1               5                   10                  15      


Pro Phe Glu Met Xaa Xaa Ser Glu His Ile Gln Asp Glu Pro Gly Val 
            20                  25                  30          


Cys Ile Ile Pro His Val His Ser Lys Asp Lys Ser His Ile Pro Ser 
        35                  40                  45              


Ser Leu Asp Asn Val Asn His Lys Ile Val His Glu Cys Gln Glu Leu 
    50                  55                  60                  


Ser Ser Pro Val Ile Xaa Xaa Ser Pro Ala Ser Phe Glu Glu Asn Lys 
65                  70                  75                  80  


Ile Val Leu Glu Glu Gln Ser Ser Arg Glu Glu Ile Ser Leu Met Glu 
                85                  90                  95      


Lys Val Lys Glu Asn Ala Xaa Pro Xaa Arg Asn Xaa Ile Ser Lys Val 
            100                 105                 110         


Xaa Ser Asn Leu Arg Ile Arg Ser Arg Leu Ala Lys Pro Lys Pro Asn 
        115                 120                 125             


Leu Glu Lys Xaa Leu Gly Xaa Asn Arg Leu Asp Asp Tyr Gln Glu Val 
    130                 135                 140                 


Ser Ser Leu Cys Val Xaa Lys Gly Ala Glu Met Glu Xaa Gln Arg Glu 
145                 150                 155                 160 


Xaa Glu Lys Asn Ala Ser Lys Ala Xaa Glu Leu Glu Asn Lys Asn Leu 
                165                 170                 175     


Gly Pro Val Xaa Xaa Ala Glu Asn Lys Asp Gln Ser Lys Leu Ala Cys 
            180                 185                 190         


Val His Gly Ile Lys Gly Xaa Ser Ile Ser Ser Glu Val Asn Leu Xaa 
        195                 200                 205             


Glu Arg Asn Glu Asn Gln Glu Glu Ser Ser Gln Glu Val His Met Leu 
    210                 215                 220                 


Ser Val Ala Pro Val Ala Ser Ser Glu Xaa Gly Pro Cys Xaa Leu Gly 
225                 230                 235                 240 


Leu Asp Arg Gly Leu Gly Glu Asn Ser Val Glu Glu Pro Gln Ile Lys 
                245                 250                 255     


Asp Ser Lys Gly Asp Ser Val Leu Xaa Leu Pro Val Pro Glu Tyr Xaa 
            260                 265                 270         


Pro Xaa Ser Ile Pro Glu Val Gln Gln Glu Asn Ile Ile Asn Pro Gln 
        275                 280                 285             


Asp Leu Xaa Val Asn Leu Val Ala Asn Val Pro Gln Asp Gly Glu Asp 
    290                 295                 300                 


Glu Gln Ala Phe Ile Leu Xaa Leu Val Glu Ile Pro Ala Asn Ala Val 
305                 310                 315                 320 


Glu Glu Phe Xaa Asp Ala Xaa Ala Gln Phe Met Pro Asn Pro Leu Leu 
                325                 330                 335     


Pro Ala Pro Ile Leu Val Lys Ser Val Asn Xaa Glu Glu Arg Gly Asp 
            340                 345                 350         


Met Ser Ile Cys Leu Pro Ala Xaa Ser Val Gly Gln Asp Ala Met Gly 
        355                 360                 365             


Leu Ser Ile Ser Gly Arg Asp Asn Ser Lys Lys Pro Pro Asp Asn Leu 
    370                 375                 380                 


Asp Leu Val Ser Arg Lys Arg Phe Gln Cys Arg Leu Asp Lys Asn Asp 
385                 390                 395                 400 


His Ile Pro Pro Ala Lys Lys Arg Ser Leu Xaa Leu Arg Asp Asp Cys 
                405                 410                 415     


Gln Glu Tyr Xaa Xaa Glu Val His Ser Lys Glu Leu Xaa Asn Val Phe 
            420                 425                 430         


Glu Glu Xaa Gly Glu Ser His Lys Gly Gln Asp Ile Phe Leu Xaa Ser 
        435                 440                 445             


Gly Ser Xaa Leu Xaa Xaa Pro Glu Pro Gln Arg Gln Gln Val Glu Ala 
    450                 455                 460                 


Ala Phe Gln Ser Arg Gly Ser Arg Ser Pro Asp Ala Cys Met Asp Lys 
465                 470                 475                 480 


Asn Val Pro Gln Leu Pro Gln Asp Glu Met Ile Val Ser Asp Lys Glu 
                485                 490                 495     


Glu Arg Xaa Asp Ala Ala Pro Lys Ser Gln Gln Met Asp Ser Arg Xaa 
            500                 505                 510         


Ser Ser Ser Lys Ala Ser Leu Ser Arg Pro Gly Arg Arg Pro Leu Gly 
        515                 520                 525             


Phe Leu Ser Leu Ile Cys Ser Lys Asn Ser Leu Glu Ser Asp Glu Pro 
    530                 535                 540                 


Met Gln Val His Ser Lys Lys Arg Leu Lys Pro Leu Ile Pro Gly Leu 
545                 550                 555                 560 


Arg Lys Lys Leu Lys Arg Ser Asn Pro Phe Asn Glu Ser Gln Glu Lys 
                565                 570                 575     


Asn Arg Glu Ser Ser Asp Leu Leu Pro Ser Pro Ser Val Ile Xaa Xaa 
            580                 585                 590         


Gln Ser Glu Asn Ile Ser Ser Ser Ala Xaa Gln Arg Pro Phe 
        595                 600                 605     


<210> 4159
<211> 583
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(573)
<223> Selenocysteine

<400> 4159
Xaa Arg Lys Asp Cys Val Gly Ser Lys Glu Ser Ala Leu Ala Lys Ile 
1               5                   10                  15      


Asp Ala Glu Leu Glu Glu Val Gly Pro Ser Arg Arg Val Gly Glu Glu 
            20                  25                  30          


Xaa Val Gly Asp Asn Ser Pro Ser Ser Val Val Glu Glu Gln Tyr Leu 
        35                  40                  45              


Asn Lys Leu Xaa Ser Cys Pro Gln Pro Leu Asn Glu Xaa Ser Tyr Ser 
    50                  55                  60                  


Lys Ile Ala Leu Asp Gly Lys Xaa Xaa Ile Ser Ser Xaa Ser Glu Tyr 
65                  70                  75                  80  


Glu Arg Asn Arg Gly Glu Arg Arg Ser His Lys Lys Phe Lys Pro Asn 
                85                  90                  95      


Val Xaa Arg Gly Arg Gly Ser Lys Arg Val Arg Gly Lys Xaa Ser Lys 
            100                 105                 110         


Lys Glu Pro Arg Ala Ser Lys Ala Met Leu Val Xaa Leu Arg Ala Ser 
        115                 120                 125             


Gln Glu Glu Asp Asp Asp Ala Asp Asp Phe Glu Ser Asp Tyr Glu Glu 
    130                 135                 140                 


Glu Ser Tyr His Leu Ala Pro Glu Glu Val Asn Lys Ala Pro Val Phe 
145                 150                 155                 160 


Val Pro Val Gly Leu Arg Ser Pro Glu Pro Val Ser Ala Gln Ile Glu 
                165                 170                 175     


Glu Xaa Met Glu Glu Leu Glu Ile Xaa Val Asn Val Pro Asp Val Gly 
            180                 185                 190         


Cys Ile Ala Val Val Glu His Glu Leu Pro Asn Xaa Asp Val Xaa Xaa 
        195                 200                 205             


Glu Glu Met Lys Gln Glu Glu Asn Leu Ser Val Pro Phe Glu Met Xaa 
    210                 215                 220                 


Xaa Ser Glu His Ile Gln Asp Glu Pro Gly Xaa Asn Asp Gly Ser Xaa 
225                 230                 235                 240 


Glu Ala Ala Ile Xaa Leu Leu Xaa Met Gly Asp Leu Val Leu Gln Ser 
                245                 250                 255     


Glu Ile Ser Ser Glu Gln Gly Asp Gly Val Cys Ile Ile Pro His Val 
            260                 265                 270         


His Ser Lys Asp Lys Ser His Ile Pro Ser Ser Leu Asp Asn Val Asn 
        275                 280                 285             


His Lys Ile Val His Glu Cys Gln Glu Leu Ser Ser Pro Val Ile Xaa 
    290                 295                 300                 


Xaa Ser Pro Ala Ser Phe Glu Glu Asn Lys Ile Val Leu Glu Glu Gln 
305                 310                 315                 320 


Ser Ser Arg Glu Glu Ile Ser Leu Met Glu Lys Val Lys Glu Asn Ala 
                325                 330                 335     


Xaa Pro Xaa Arg Asn Xaa Ile Ser Lys Val Xaa Ser Asn Leu Arg Ile 
            340                 345                 350         


Arg Ser Arg Leu Ala Lys Pro Lys Pro Asn Leu Glu Lys Xaa Leu Gly 
        355                 360                 365             


Xaa Asn Arg Leu Asp Asp Tyr Gln Glu Val Ser Ser Leu Cys Val Xaa 
    370                 375                 380                 


Lys Gly Ala Glu Met Glu Xaa Gln Arg Glu Xaa Glu Lys Asn Ala Ser 
385                 390                 395                 400 


Lys Ala Xaa Glu Leu Glu Asn Lys Asn Leu Gly Pro Val Xaa Xaa Ala 
                405                 410                 415     


Glu Asn Lys Asp Gln Ser Lys Leu Ala Cys Val His Gly Ile Lys Gly 
            420                 425                 430         


Xaa Ser Ile Ser Ser Glu Val Asn Leu Xaa Glu Arg Asn Glu Asn Gln 
        435                 440                 445             


Glu Glu Ser Ser Gln Glu Val His Met Leu Ser Val Ala Pro Val Ala 
    450                 455                 460                 


Ser Ser Glu Xaa Gly Pro Cys Xaa Leu Gly Leu Asp Arg Gly Leu Gly 
465                 470                 475                 480 


Glu Asn Ser Val Glu Glu Pro Gln Ile Lys Asp Ser Lys Gly Asp Ser 
                485                 490                 495     


Val Leu Xaa Leu Pro Val Pro Glu Tyr Xaa Pro Xaa Ser Ile Pro Glu 
            500                 505                 510         


Val Gln Gln Glu Asn Ile Ile Asn Pro Gln Asp Leu Xaa Val Phe Val 
        515                 520                 525             


Tyr Gln Gln Leu Gln Leu Val Lys Met Pro Trp Val Tyr Leu Phe Leu 
    530                 535                 540                 


Glu Glu Ile Ile Leu Lys Ser Arg Leu Ile Ile Trp Ile Leu Tyr Leu 
545                 550                 555                 560 


Gly Arg Asp Phe Asn Ala Gly Leu Ile Lys Met Xaa Xaa Phe Leu Leu 
                565                 570                 575     


Pro Lys Asn Val His Ser Leu 
            580             


<210> 4160
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<400> 4160
Gly Asn His Ser Tyr Leu Glu Ser Leu Xaa Asp Lys Ser Lys Ala Glu 
1               5                   10                  15      


Val Gln Trp His Asp Leu Gly Leu Leu Gln Pro Pro Pro Pro Gly Phe 
            20                  25                  30          


Lys Gln Phe Pro Cys Leu Ser Leu Leu Ser Ile Trp Asp Tyr Arg His 
        35                  40                  45              


Ala Pro Pro Arg Pro Ala Asn 
    50                  55  


<210> 4161
<211> 132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 4161
Leu Asn Val Xaa Glu Asn Glu Cys Gln Asn Tyr Lys Arg Cys Leu Glu 
1               5                   10                  15      


Ile Leu Glu Gln Met Asn Glu Asp Asp Ser Glu Gln Leu Gln Met Glu 
            20                  25                  30          


Leu Lys Glu Leu Ala Leu Glu Glu Glu Arg Leu Ile Gln Glu Leu Glu 
        35                  40                  45              


Asp Val Glu Lys Asn Arg Lys Ile Val Ala Glu Asn Leu Glu Lys Val 
    50                  55                  60                  


Gln Ala Glu Ala Glu Arg Leu Asp Gln Glu Glu Ala Gln Met Asp Val 
65                  70                  75                  80  


Glu Lys Gly Lys Ile Glu Asp Xaa Gly Gly Ser Gly Gly Ser Tyr Ser 
                85                  90                  95      


Ile Lys Xaa Gln Phe Asn Ser Glu Glu Gln Trp Xaa Lys Ala Leu Lys 
            100                 105                 110         


Phe Met Leu Xaa Asn Leu Lys Trp Gly Leu Ala Trp Val Ser Ser Gln 
        115                 120                 125             


Phe Tyr Asn Lys 
    130         


<210> 4162
<211> 20
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<400> 4162
Met Glu Gly Ser Lys Xaa Ser Asn Asn Ser Xaa Met Gln Val Ser Phe 
1               5                   10                  15      


Val Cys Gln Arg 
            20  


<210> 4163
<211> 59
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<400> 4163
Met Glu Gly Ser Lys Xaa Ser Asn Asn Ser Xaa Met Gln Val Ser Phe 
1               5                   10                  15      


Val Cys Gln Arg Cys Ser Gln Pro Leu Lys Leu Asp Xaa Ser Phe Lys 
            20                  25                  30          


Ile Leu Asp Arg Val Xaa Ile Gln Glu Leu Xaa Ala Pro Leu Leu Xaa 
        35                  40                  45              


Xaa Ala Gln Ala Lys Pro Gly Glu Xaa Gln Glu 
    50                  55                  


<210> 4164
<211> 450
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<400> 4164
Met Glu Gly Ser Lys Xaa Ser Asn Asn Ser Xaa Met Gln Val Ser Phe 
1               5                   10                  15      


Val Cys Gln Arg Cys Ser Gln Pro Leu Lys Leu Asp Xaa Ser Phe Lys 
            20                  25                  30          


Ile Leu Asp Arg Val Xaa Ile Gln Glu Leu Xaa Ala Pro Leu Leu Xaa 
        35                  40                  45              


Xaa Ala Gln Ala Lys Pro Gly Glu Xaa Gln Glu Glu Glu Xaa Asn Ser 
    50                  55                  60                  


Gly Glu Glu Pro Phe Ile Glu Xaa Pro Arg Gln Asp Gly Val Ser Arg 
65                  70                  75                  80  


Arg Phe Ile Pro Pro Ala Arg Met Met Ser Xaa Glu Ser Ala Asn Ser 
                85                  90                  95      


Phe Xaa Leu Ile Gly Glu Ala Ser Asp Gly Gly Xaa Met Glu Asn Leu 
            100                 105                 110         


Ser Arg Arg Leu Lys Val Xaa Gly Asp Leu Phe Asp Ile Met Ser Gly 
        115                 120                 125             


Gln Xaa Asp Val Asp His Pro Leu Cys Glu Glu Cys Xaa Asp Xaa Leu 
    130                 135                 140                 


Leu Asp Gln Leu Asp Xaa Gln Leu Asn Val Xaa Glu Asn Glu Cys Gln 
145                 150                 155                 160 


Asn Tyr Lys Arg Cys Leu Glu Ile Leu Glu Gln Met Asn Glu Asp Asp 
                165                 170                 175     


Ser Glu Gln Leu Gln Met Glu Leu Lys Glu Leu Ala Leu Glu Glu Glu 
            180                 185                 190         


Arg Leu Ile Gln Glu Leu Glu Asp Val Glu Lys Asn Arg Lys Ile Val 
        195                 200                 205             


Ala Glu Asn Leu Glu Lys Val Gln Ala Glu Ala Glu Arg Leu Asp Gln 
    210                 215                 220                 


Glu Glu Ala Gln Tyr Gln Arg Glu Tyr Ser Glu Phe Lys Arg Gln Gln 
225                 230                 235                 240 


Leu Glu Leu Asp Asp Glu Leu Lys Ser Val Glu Asn Gln Met Arg Tyr 
                245                 250                 255     


Ala Gln Xaa Gln Leu Asp Lys Leu Lys Lys Xaa Asn Val Phe Asn Ala 
            260                 265                 270         


Xaa Phe His Ile Trp His Ser Gly Gln Phe Gly Xaa Ile Asn Asn Phe 
        275                 280                 285             


Arg Leu Gly Arg Leu Pro Ser Val Pro Val Glu Trp Asn Glu Ile Asn 
    290                 295                 300                 


Ala Ala Trp Gly Gln Xaa Val Leu Leu Leu His Ala Leu Ala Asn Lys 
305                 310                 315                 320 


Met Gly Leu Lys Phe Gln Arg Tyr Arg Leu Val Pro Tyr Gly Asn His 
                325                 330                 335     


Ser Tyr Leu Glu Ser Leu Xaa Asp Lys Ser Lys Glu Leu Pro Leu Tyr 
            340                 345                 350         


Cys Ser Gly Gly Leu Arg Phe Phe Trp Asp Asn Lys Phe Asp His Ala 
        355                 360                 365             


Met Val Ala Phe Leu Asp Cys Val Gln Gln Phe Lys Glu Glu Val Glu 
    370                 375                 380                 


Lys Gly Glu Xaa Arg Phe Cys Leu Pro Tyr Arg Met Asp Val Glu Lys 
385                 390                 395                 400 


Gly Lys Ile Glu Asp Xaa Gly Gly Ser Gly Gly Ser Tyr Ser Ile Lys 
                405                 410                 415     


Xaa Gln Phe Asn Ser Glu Glu Gln Trp Xaa Lys Ala Leu Lys Phe Met 
            420                 425                 430         


Leu Xaa Asn Leu Lys Trp Gly Leu Ala Trp Val Ser Ser Gln Phe Tyr 
        435                 440                 445             


Asn Lys 
    450 


<210> 4165
<211> 176
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<400> 4165
Met Glu Gly Ser Lys Xaa Ser Asn Asn Ser Xaa Met Gln Val Ser Phe 
1               5                   10                  15      


Val Cys Gln Arg Cys Ser Gln Pro Leu Lys Leu Asp Xaa Ser Phe Lys 
            20                  25                  30          


Ile Leu Asp Arg Val Xaa Ile Gln Glu Leu Xaa Ala Pro Leu Leu Xaa 
        35                  40                  45              


Xaa Ala Gln Ala Lys Pro Gly Glu Xaa Gln Glu Glu Glu Xaa Asn Ser 
    50                  55                  60                  


Gly Glu Glu Pro Phe Ile Glu Xaa Pro Arg Gln Asp Gly Val Ser Arg 
65                  70                  75                  80  


Arg Phe Ile Pro Pro Ala Arg Arg Cys Leu Glu Ile Leu Glu Gln Met 
                85                  90                  95      


Asn Glu Asp Asp Ser Glu Gln Leu Gln Met Glu Leu Lys Glu Leu Ala 
            100                 105                 110         


Leu Glu Glu Glu Arg Leu Ile Gln Glu Leu Glu Asp Val Glu Lys Asn 
        115                 120                 125             


Arg Lys Ile Val Ala Glu Asn Leu Glu Lys Val Gln Ala Glu Ala Glu 
    130                 135                 140                 


Arg Leu Asp Gln Glu Glu Ala Gln His Ser Gly Gln Phe Gly Xaa Ile 
145                 150                 155                 160 


Asn Asn Phe Arg Leu Gly Arg Leu Pro Ser Val Pro Val Glu Trp Asn 
                165                 170                 175     


<210> 4166
<211> 279
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<400> 4166
Met Glu Gly Ser Lys Xaa Ser Asn Asn Ser Xaa Met Gln Val Ser Phe 
1               5                   10                  15      


Val Cys Gln Arg Cys Ser Gln Pro Leu Lys Leu Asp Xaa Ser Phe Lys 
            20                  25                  30          


Ile Leu Asp Arg Val Xaa Ile Gln Glu Leu Xaa Ala Pro Leu Leu Xaa 
        35                  40                  45              


Xaa Ala Gln Ala Lys Pro Gly Glu Xaa Gln Glu Glu Glu Xaa Asn Ser 
    50                  55                  60                  


Gly Glu Glu Pro Phe Ile Glu Xaa Pro Arg Gln Asp Gly Val Ser Arg 
65                  70                  75                  80  


Arg Phe Ile Pro Pro Ala Arg Arg Cys Leu Glu Ile Leu Glu Gln Met 
                85                  90                  95      


Asn Glu Asp Asp Ser Glu Gln Leu Gln Met Glu Leu Lys Glu Leu Ala 
            100                 105                 110         


Leu Glu Glu Glu Arg Leu Ile Gln Glu Leu Glu Asp Val Glu Lys Asn 
        115                 120                 125             


Arg Lys Ile Val Ala Glu Asn Leu Glu Lys Val Gln Ala Glu Ala Glu 
    130                 135                 140                 


Arg Leu Asp Gln Glu Glu Ala Gln Tyr Gln Arg Glu Tyr Ser Glu Phe 
145                 150                 155                 160 


Lys Arg Gln Gln Leu Glu Leu Asp Asp Glu Leu Lys Ser Val Glu Asn 
                165                 170                 175     


Gln Met Arg Tyr Ala Gln Xaa Gln Leu Asp Lys Leu Lys Lys Xaa Asn 
            180                 185                 190         


Val Phe Asn Ala Xaa Phe His Ile Trp His Ser Gly Gln Phe Gly Xaa 
        195                 200                 205             


Ile Asn Asn Phe Arg Leu Gly Arg Leu Pro Ser Val Pro Val Glu Trp 
    210                 215                 220                 


Asn Glu Ile Asn Ala Ala Trp Gly Gln Xaa Val Leu Leu Leu His Ala 
225                 230                 235                 240 


Leu Ala Asn Lys Met Gly Leu Lys Phe Gln Arg Tyr Arg Leu Val Pro 
                245                 250                 255     


Tyr Gly Asn His Ser Tyr Leu Glu Ser Leu Xaa Asp Lys Ser Lys Asp 
            260                 265                 270         


Gly Cys Gly Glu Arg Gln Asp 
        275                 


<210> 4167
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<400> 4167
Met Glu Gly Ser Lys Xaa Ser Asn Asn Ser Xaa Met Gln Val Ser Phe 
1               5                   10                  15      


Val Cys Gln Arg Cys Ser Gln Pro Leu Lys Leu Asp Xaa Ser Phe Lys 
            20                  25                  30          


Ile Leu Asp Arg Val Xaa Ile Gln Glu Leu Xaa Gly Gln Arg Asp Pro 
        35                  40                  45              


Trp Lys Glu Gly Gly Gln Glu Cys Gly Ser Ser Ile Xaa Tyr His Ser 
    50                  55                  60                  


Pro Gly Glu Xaa Arg Arg Asp Pro Gly Gly Arg Asp 
65                  70                  75      


<210> 4168
<211> 109
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<400> 4168
Xaa Ala Ala Trp Gly Gln Xaa Val Leu Leu Leu His Ala Leu Ala Asn 
1               5                   10                  15      


Lys Met Gly Leu Lys Phe Gln Arg Ser Cys Arg Tyr Xaa Val Leu Gly 
            20                  25                  30          


Gly Cys Gly Phe Ser Gly Xaa Xaa Ser Leu Xaa Met Gln Trp Trp Leu 
        35                  40                  45              


Ser Trp Xaa Val Cys Ser Ser Ser Lys Lys Arg Leu Arg Lys Ala Arg 
    50                  55                  60                  


His Val Phe Val Phe Pro Xaa Gly Trp Met Trp Arg Lys Ala Arg Leu 
65                  70                  75                  80  


Lys Xaa Gln Glu Ala Val Ala Ala Pro Ile Pro Ser Lys Pro Ser Leu 
                85                  90                  95      


Xaa Leu Arg Ser Ser Gly Gln Lys Leu Ser Ser Ser Cys 
            100                 105                 


<210> 4169
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<400> 4169
Xaa Ala Gln Xaa Gln Leu Asp Lys Leu Lys Lys Xaa Asn Val Phe Asn 
1               5                   10                  15      


Ala Xaa Phe His Ile Trp His Ser Gly Gln Phe Gly Xaa Ile Asn Asn 
            20                  25                  30          


Phe Arg Leu Gly Arg Leu Pro Ser Val Pro Val Glu Trp Asn Glu Ile 
        35                  40                  45              


Asn Ala Ala Trp Gly Gln Xaa Val Leu Leu Leu His Ala Leu Ala Asn 
    50                  55                  60                  


Lys Met Gly Leu Lys Phe Gln Arg 
65                  70          


<210> 4170
<211> 229
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<400> 4170
Xaa Gly Gln Xaa Asp Val Asp His Pro Leu Cys Glu Glu Cys Xaa Asp 
1               5                   10                  15      


Xaa Leu Leu Asp Gln Leu Asp Xaa Gln Leu Asn Val Xaa Glu Asn Glu 
            20                  25                  30          


Cys Gln Asn Tyr Lys Arg Cys Leu Glu Ile Leu Glu Gln Met Asn Glu 
        35                  40                  45              


Asp Asp Ser Glu Gln Leu Gln Met Glu Leu Lys Glu Leu Ala Leu Glu 
    50                  55                  60                  


Glu Glu Arg Leu Ile Gln Glu Leu Glu Asp Val Glu Lys Asn Arg Lys 
65                  70                  75                  80  


Ile Val Ala Glu Asn Leu Glu Lys Val Gln Ala Glu Ala Glu Arg Leu 
                85                  90                  95      


Asp Gln Glu Glu Ala Gln Tyr Gln Arg Glu Tyr Ser Glu Phe Lys Arg 
            100                 105                 110         


Gln Gln Leu Glu Leu Asp Asp Glu Leu Lys Ser Val Glu Asn Gln Met 
        115                 120                 125             


Arg Tyr Ala Gln Xaa Gln Leu Asp Lys Leu Lys Lys Xaa Asn Val Phe 
    130                 135                 140                 


Asn Ala Xaa Phe His Ile Trp His Ser Gly Gln Phe Gly Xaa Ile Asn 
145                 150                 155                 160 


Asn Phe Arg Leu Gly Arg Leu Pro Ser Val Pro Val Glu Trp Asn Glu 
                165                 170                 175     


Ile Asn Ala Ala Trp Gly Gln Xaa Val Leu Leu Leu His Ala Leu Ala 
            180                 185                 190         


Asn Lys Met Gly Leu Lys Phe Gln Arg Tyr Arg Leu Val Pro Tyr Gly 
        195                 200                 205             


Asn His Ser Tyr Leu Glu Ser Leu Xaa Asp Lys Ser Lys Asp Gly Cys 
    210                 215                 220                 


Gly Glu Arg Gln Asp 
225                 


<210> 4171
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<400> 4171
Xaa His Ser Gly Gln Phe Gly Xaa Ile Asn Asn Phe Arg Leu Gly Arg 
1               5                   10                  15      


Leu Pro Ser Val Pro Val Glu Trp Asn Glu Ile Asn Ala Ala Trp Gly 
            20                  25                  30          


Gln Xaa Val Leu Leu Leu His Ala Leu Ala Asn Lys Met Gly Leu Lys 
        35                  40                  45              


Phe Gln Arg Met Asp Val Glu Lys Gly Lys Ile Glu Asp Xaa Gly Gly 
    50                  55                  60                  


Ser Gly Gly Ser Tyr Ser Ile Lys Xaa Gln Phe Asn Ser Glu Glu Gln 
65                  70                  75                  80  


Trp Xaa Lys Ala Leu Lys Phe Met Leu Xaa Asn Leu Lys Trp Gly Leu 
                85                  90                  95      


Ala Trp Val Ser Ser Gln Phe Tyr Asn Lys 
            100                 105     


<210> 4172
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<400> 4172
Met Gln Lys Ile Val Gln Xaa Asp Glu Ile Xaa Asn Xaa Gln Ala Phe 
1               5                   10                  15      


Arg Lys Gly Lys Arg Lys Arg Xaa Glu Xaa Met Asp Ser Glu Asn Ala 
            20                  25                  30          


Asn Ser Asp Met Asp Lys Gly Gln Arg Asp Pro Tyr Ser Gly Asn Ala 
        35                  40                  45              


Phe Leu Pro Gly Glu Ser Ser Ser Glu Asp Glu Glu Pro Leu Ala Glu 
    50                  55                  60                  


Leu Ser Lys Glu Glu Leu Cys Ala Lys Ile Lys Ser Leu Lys Glu Lys 
65                  70                  75                  80  


Leu Xaa Asn Xaa Arg Lys Glu Asn Ser Arg Leu Arg Gln Ser Leu Val 
                85                  90                  95      


Met Leu Gln Ala Trp Ser Arg Glu Leu Pro 
            100                 105     


<210> 4173
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(124)
<223> Selenocysteine

<400> 4173
Met Gln Lys Ile Val Gln Xaa Asp Glu Ile Xaa Asn Xaa Gln Ala Phe 
1               5                   10                  15      


Arg Lys Gly Lys Arg Lys Arg Xaa Glu Xaa Met Asp Ser Glu Asn Ala 
            20                  25                  30          


Asn Ser Asp Met Asp Lys Gly Gln Arg Asp Pro Tyr Ser Gly Asn Ala 
        35                  40                  45              


Phe Leu Pro Gly Glu Ser Ser Ser Glu Asp Glu Glu Pro Leu Ala Glu 
    50                  55                  60                  


Leu Ser Lys Glu Glu Leu Cys Ala Lys Ile Lys Ser Leu Lys Glu Lys 
65                  70                  75                  80  


Leu Xaa Asn Xaa Arg Lys Glu Asn Ser Arg Leu Arg Gln Ser Leu Val 
                85                  90                  95      


Met Leu Gln Gly Asn Lys Leu Asp Ile Xaa Xaa Glu Lys Xaa Ile Leu 
            100                 105                 110         


His Gly Gly Met Lys Xaa Leu Asn Val Val Xaa Xaa Ser Ser His Pro 
        115                 120                 125             


Val 
    


<210> 4174
<211> 279
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<400> 4174
Met Gln Lys Ile Val Gln Xaa Asp Glu Ile Xaa Asn Xaa Gln Ala Phe 
1               5                   10                  15      


Arg Lys Gly Lys Arg Lys Arg Xaa Glu Xaa Met Asp Ser Glu Asn Ala 
            20                  25                  30          


Asn Ser Asp Met Asp Lys Gly Gln Arg Asp Pro Tyr Ser Gly Asn Ala 
        35                  40                  45              


Phe Leu Pro Gly Glu Ser Ser Ser Glu Asp Glu Glu Pro Leu Ala Glu 
    50                  55                  60                  


Leu Ser Lys Glu Glu Leu Cys Ala Lys Ile Lys Ser Leu Lys Glu Lys 
65                  70                  75                  80  


Leu Xaa Asn Xaa Arg Lys Glu Asn Ser Arg Leu Arg Gln Ser Leu Val 
                85                  90                  95      


Met Leu Gln Val Leu Pro Gln Ala Val Xaa Gln Phe Glu Glu Leu Val 
            100                 105                 110         


Gly Met Ala Glu Ala Leu Leu Lys Gly Gly Gly Xaa Met Ser Xaa Ser 
        115                 120                 125             


Ala Ser Xaa Leu Trp Arg Ala Xaa Asn Asn Ser Ser Pro Asp Ser Phe 
    130                 135                 140                 


Ala Ser Xaa Cys Ser Asn Ser Asn Ser Asn Ser Ser Ser Pro Val Ser 
145                 150                 155                 160 


Leu Lys Pro Glu Glu Glu His Gln Xaa Asp Glu Lys Gln Phe Gln Ile 
                165                 170                 175     


Glu Lys Trp Gln Ile Ala Arg Cys Asn Lys Ser Lys Pro Gln Lys Phe 
            180                 185                 190         


Ile Asn Asp Leu Met Gln Val Leu Tyr Xaa Asn Glu Tyr Met Ala Xaa 
        195                 200                 205             


His Ser Leu Xaa Gly Ala Lys Ser Ser Xaa Ser Arg Asp Lys Ala Val 
    210                 215                 220                 


Lys Pro Ala Met Asn Gln Asn Glu Val Gln Glu Ile Ile Gly Val Xaa 
225                 230                 235                 240 


Lys Gln Leu Phe Pro Asn Xaa Asp Asp Val Ser Ile Arg Arg Met Ile 
                245                 250                 255     


Gly Gln Lys Leu Asn Asn Cys Xaa Lys Lys Pro Asn Leu Ser Lys Asn 
            260                 265                 270         


Leu Asn Ser Gln Asp Ile Lys 
        275                 


<210> 4175
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 4175
Met Glu Ser Lys Glu Lys Arg Ala Val Asn Ser Leu Ser Met Glu Asn 
1               5                   10                  15      


Ala Asn Gln Glu Asn Glu Glu Lys Glu Gln Val Ala Asn Lys Gly Glu 
            20                  25                  30          


Pro Leu Ala Leu Pro Leu Asp Ala Gly Glu Tyr Cys Val Pro Arg Gly 
        35                  40                  45              


Asn Arg Arg Arg Phe Arg Val Arg Gln Pro Ile Leu Gln Tyr Arg Trp 
    50                  55                  60                  


Asp Met Met His Arg Leu Gly Glu Pro Gln Ala Arg Met Arg Glu Glu 
65                  70                  75                  80  


Asn Met Glu Arg Ile Gly Glu Glu Val Arg Gln Leu Met Glu Lys Leu 
                85                  90                  95      


Arg Glu Lys Gln Leu Ser His Ser Leu Arg Ala Val Ser Xaa Asp Pro 
            100                 105                 110         


Pro His His Asp His His Asp Glu Phe Cys Leu Met Pro 
        115                 120                 125 


<210> 4176
<211> 111
<212> PRT
<213> Homo sapiens

<400> 4176
Met Ala Asn Ile His Gln Glu Asn Glu Glu Met Glu Gln Pro Met Gln 
1               5                   10                  15      


Asn Gly Glu Glu Asp Arg Pro Leu Gly Gly Gly Glu Gly His Gln Pro 
            20                  25                  30          


Ala Gly Asn Arg Arg Gly Gln Ala Arg Arg Leu Ala Pro Asn Phe Arg 
        35                  40                  45              


Trp Ala Ile Pro Asn Arg Gln Ile Asn Asp Gly Met Gly Gly Asp Gly 
    50                  55                  60                  


Asp Asp Met Glu Ile Phe Met Glu Glu Met Arg Glu Ile Arg Arg Lys 
65                  70                  75                  80  


Leu Arg Glu Leu Gln Leu Arg Asn Cys Leu Arg Ile Leu Met Gly Glu 
                85                  90                  95      


Leu Ser Asn His His Asp His His Asp Glu Phe Cys Leu Met Pro 
            100                 105                 110     


<210> 4177
<211> 101
<212> PRT
<213> Homo sapiens

<400> 4177
Met Glu Gln Pro Met Gln Asn Gly Glu Glu Asp Arg Pro Leu Gly Gly 
1               5                   10                  15      


Gly Glu Gly His Gln Pro Ala Gly Asn Arg Arg Gly Gln Ala Arg Arg 
            20                  25                  30          


Leu Ala Pro Asn Phe Arg Trp Ala Ile Pro Asn Arg Gln Ile Asn Asp 
        35                  40                  45              


Gly Met Gly Gly Asp Gly Asp Asp Met Glu Ile Phe Met Glu Glu Met 
    50                  55                  60                  


Arg Glu Ile Arg Arg Lys Leu Arg Glu Leu Gln Leu Arg Asn Cys Leu 
65                  70                  75                  80  


Arg Ile Leu Met Gly Glu Leu Ser Asn His His Asp His His Asp Glu 
                85                  90                  95      


Phe Cys Leu Met Pro 
            100     


<210> 4178
<211> 100
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<400> 4178
Met Arg Ala Leu Xaa Leu Leu Ala Leu Leu Ala Leu Ala Ala Leu Cys 
1               5                   10                  15      


Ile Ala Gly Gln Ala Gly Ala Lys Pro Ser Gly Ala Glu Ser Ser Lys 
            20                  25                  30          


Gly Ala Ala Phe Val Ser Lys Gln Glu Gly Ser Glu Val Val Lys Arg 
        35                  40                  45              


Pro Arg Arg Tyr Leu Tyr Gln Trp Leu Gly Ala Pro Val Pro Tyr Pro 
    50                  55                  60                  


Asp Pro Leu Glu Pro Arg Arg Glu Val Cys Glu Leu Asn Pro Asp Cys 
65                  70                  75                  80  


Asp Glu Leu Ala Asp His Ile Gly Phe Gln Glu Ala Tyr Arg Arg Phe 
                85                  90                  95      


Tyr Gly Pro Val 
            100 


<210> 4179
<211> 368
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<400> 4179
Met Trp Pro Leu Trp Arg Leu Val Ser Leu Leu Ala Leu Ser Gln Ala 
1               5                   10                  15      


Leu Pro Phe Glu Gln Arg Gly Phe Trp Asp Phe Xaa Leu Asp Asp Gly 
            20                  25                  30          


Pro Phe Met Met Asn Asp Glu Glu Ala Ser Gly Ala Asp Xaa Ser Gly 
        35                  40                  45              


Val Leu Asp Pro Asp Ser Val Xaa Pro Xaa Tyr Ser Ala Met Cys Pro 
    50                  55                  60                  


Phe Gly Cys His Cys His Leu Arg Val Val Gln Cys Ser Asp Leu Gly 
65                  70                  75                  80  


Leu Lys Ser Val Pro Lys Glu Ile Ser Pro Asp Xaa Xaa Leu Leu Asp 
                85                  90                  95      


Leu Gln Asn Asn Asp Ile Ser Glu Leu Arg Lys Asp Asp Phe Lys Gly 
            100                 105                 110         


Leu Gln His Leu Tyr Ala Leu Val Leu Val Asn Asn Lys Ile Ser Lys 
        115                 120                 125             


Ile His Glu Lys Ala Phe Ser Pro Leu Arg Lys Leu Gln Lys Leu Tyr 
    130                 135                 140                 


Ile Ser Lys Asn His Leu Val Glu Ile Pro Pro Asn Leu Pro Ser Ser 
145                 150                 155                 160 


Leu Val Glu Leu Arg Ile His Asp Asn Arg Ile Arg Lys Val Pro Lys 
                165                 170                 175     


Gly Val Phe Ser Gly Leu Arg Asn Met Asn Cys Ile Glu Met Gly Gly 
            180                 185                 190         


Asn Pro Leu Glu Asn Ser Gly Phe Glu Pro Gly Ala Phe Asp Gly Leu 
        195                 200                 205             


Lys Leu Asn Tyr Leu Arg Ile Ser Glu Ala Lys Leu Xaa Gly Ile Pro 
    210                 215                 220                 


Lys Asp Leu Pro Glu Xaa Leu Asn Glu Leu His Leu Asp His Asn Lys 
225                 230                 235                 240 


Ile Gln Ala Ile Glu Leu Glu Asp Leu Leu Arg Tyr Ser Lys Leu Tyr 
                245                 250                 255     


Arg Leu Gly Leu Gly His Asn Gln Ile Arg Met Ile Glu Asn Gly Ser 
            260                 265                 270         


Leu Ser Phe Leu Pro Xaa Leu Arg Glu Leu His Leu Asp Asn Asn Lys 
        275                 280                 285             


Leu Ala Arg Val Pro Ser Gly Leu Pro Asp Leu Lys Leu Leu Gln Val 
    290                 295                 300                 


Val Tyr Leu His Ser Asn Asn Ile Xaa Lys Val Gly Val Asn Asp Phe 
305                 310                 315                 320 


Cys Pro Met Gly Phe Gly Val Lys Arg Ala Tyr Tyr Asn Gly Ile Ser 
                325                 330                 335     


Leu Phe Asn Asn Pro Val Pro Tyr Trp Glu Val Gln Pro Ala Xaa Phe 
            340                 345                 350         


Arg Cys Val Xaa Asp Arg Leu Ala Ile Gln Phe Gly Asn Tyr Lys Lys 
        355                 360                 365             


<210> 4180
<211> 238
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<400> 4180
Met Trp Pro Leu Trp Arg Leu Val Ser Leu Leu Ala Leu Ser Gln Ala 
1               5                   10                  15      


Leu Pro Phe Glu Gln Arg Gly Phe Trp Asp Phe Xaa Leu Asp Asp Gly 
            20                  25                  30          


Pro Phe Met Met Asn Asp Glu Glu Ala Ser Gly Ala Asp Xaa Ser Gly 
        35                  40                  45              


Val Leu Asp Pro Asp Ser Val Xaa Pro Xaa Tyr Ser Ala Met Cys Pro 
    50                  55                  60                  


Phe Gly Cys His Cys His Leu Arg Val Val Gln Cys Ser Asp Leu Gly 
65                  70                  75                  80  


Leu Lys Ser Val Pro Lys Glu Ile Ser Pro Asp Xaa Xaa Leu Leu Asp 
                85                  90                  95      


Leu Gln Asn Asn Asp Ile Ser Glu Leu Arg Lys Asp Asp Phe Lys Gly 
            100                 105                 110         


Leu Gln His Leu Tyr Val Arg Ser Trp Glu Glu Pro Ala Gly Leu Gln 
        115                 120                 125             


Gln Arg Ala Gly Val Arg Ala Leu Val Leu Val Asn Asn Lys Ile Ser 
    130                 135                 140                 


Lys Ile His Glu Lys Ala Phe Ser Pro Leu Arg Lys Leu Gln Lys Leu 
145                 150                 155                 160 


Tyr Ile Ser Lys Asn His Leu Val Glu Ile Pro Pro Asn Leu Pro Ser 
                165                 170                 175     


Ser Leu Val Glu Leu Arg Ile His Asp Asn Arg Ile Arg Lys Val Pro 
            180                 185                 190         


Lys Gly Val Phe Ser Gly Leu Arg Asn Met Asn Cys Ile Glu Met Gly 
        195                 200                 205             


Gly Asn Pro Leu Glu Asn Ser Gly Phe Glu Pro Gly Ala Phe Asp Gly 
    210                 215                 220                 


Leu Lys Leu Asn Tyr Leu Arg Ile Ser Glu Ala Lys Leu Xaa 
225                 230                 235             


<210> 4181
<211> 189
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<400> 4181
Met Lys Xaa Lys Asn Arg Pro Pro Arg Arg Arg Ala Pro Val Gln Asp 
1               5                   10                  15      


Xaa Glu Ala Xaa Pro Gly Glu Gly Xaa Pro Asp Gly Ser Leu Pro Asn 
            20                  25                  30          


Pro Gly Pro Glu Pro Ala Lys Gly Leu Arg Ser Arg Pro Ala Arg Ala 
        35                  40                  45              


Ala Ala Arg Ala Pro Gly Glu Gly Arg Arg Arg Arg Pro Gly Pro Ser 
    50                  55                  60                  


Gly Pro Gly Gly Arg Arg Asp Ser Ser Ile Gln Arg Arg Leu Glu Ser 
65                  70                  75                  80  


Asn Glu Arg Glu Arg Gln Arg Met His Lys Leu Asn Asn Ala Phe Gln 
                85                  90                  95      


Ala Leu Arg Glu Val Ile Pro His Val Arg Ala Asp Lys Lys Leu Ser 
            100                 105                 110         


Lys Ile Glu Xaa Leu Xaa Leu Ala Lys Asn Tyr Ile Lys Ser Leu Xaa 
        115                 120                 125             


Ala Xaa Ile Leu Xaa Met Ser Ser Ser Arg Leu Pro Gly Leu Glu Gly 
    130                 135                 140                 


Pro Gly Pro Lys Leu Tyr Gln His Tyr Gln Gln Gln Gln Gln Val Ala 
145                 150                 155                 160 


Gly Gly Ala Leu Gly Ala Xaa Glu Ala Gln Pro Gln Gly His Leu Gln 
                165                 170                 175     


Arg Tyr Ser Xaa Gln Ile His Ser Phe Arg Glu Gly Xaa 
            180                 185                 


<210> 4182
<211> 235
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 4182
Met Leu Arg Gly Ala Pro Gly Leu Gly Leu Xaa Ala Arg Lys Gly Ala 
1               5                   10                  15      


Glu Asp Ser Ala Glu Asp Leu Gly Gly Pro Cys Pro Glu Pro Gly Gly 
            20                  25                  30          


Asp Ser Gly Val Leu Gly Ala Asn Gly Ala Ser Cys Ser Arg Gly Glu 
        35                  40                  45              


Ala Glu Glu Pro Ala Gly Arg Arg Arg Ala Arg Pro Val Arg Ser Lys 
    50                  55                  60                  


Ala Arg Arg Met Ala Ala Asn Val Arg Glu Arg Lys Arg Ile Leu Asp 
65                  70                  75                  80  


Tyr Asn Glu Ala Phe Asn Ala Leu Arg Arg Ala Leu Arg His Asp Leu 
                85                  90                  95      


Gly Gly Lys Arg Leu Ser Lys Ile Ala Xaa Leu Arg Arg Ala Ile His 
            100                 105                 110         


Arg Ile Ala Ala Leu Ser Leu Val Leu Arg Ala Ser Pro Ala Pro Arg 
        115                 120                 125             


Gly Pro Cys Gly His Leu Glu Cys His Gly Pro Ala Ala Arg Gly Asp 
    130                 135                 140                 


Xaa Gly Asp Xaa Gly Ala Ser Pro Pro Pro Pro Ala Gly Pro Ser Leu 
145                 150                 155                 160 


Ala Arg Pro Asp Ala Ala Arg Pro Ser Val Pro Ser Ala Pro Arg Cys 
                165                 170                 175     


Ala Ser Cys Pro Pro His Ala Pro Leu Ala Arg Pro Ser Ala Val Ala 
            180                 185                 190         


Glu Gly Pro Gly Leu Ala Gln Ala Ser Gly Gly Ser Trp Arg Arg Cys 
        195                 200                 205             


Pro Gly Ala Ser Ser Ala Gly Pro Pro Pro Trp Pro Arg Gly Tyr Leu 
    210                 215                 220                 


Arg Ser Ala Pro Gly Met Gly His Pro Arg Ser 
225                 230                 235 


<210> 4183
<211> 381
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<400> 4183
Met Glu Arg Gly Met His Leu Gly Ala Ala Ala Ala Gly Glu Asp Asp 
1               5                   10                  15      


Leu Phe Leu His Lys Ser Leu Ser Ala Ser Xaa Ser Lys Arg Leu Glu 
            20                  25                  30          


Ala Ala Phe Arg Ser Xaa Pro Pro Gly Met Asp Leu Ser Leu Ala Pro 
        35                  40                  45              


Pro Pro Arg Glu Arg Pro Ala Ser Ser Ser Ser Ser Pro Leu Gly Cys 
    50                  55                  60                  


Phe Glu Pro Ala Asp Pro Glu Gly Ala Gly Leu Leu Leu Pro Pro Pro 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Ser Ala Gly Ser Gly Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Val Gly Val Pro Gly Leu Leu Val Gly Ser Ala Gly Val Gly Gly 
            100                 105                 110         


Asp Pro Ser Leu Ser Ser Leu Pro Ala Gly Ala Ala Leu Cys Leu Lys 
        115                 120                 125             


Tyr Gly Glu Ser Ala Ser Arg Gly Ser Val Ala Glu Ser Ser Gly Gly 
    130                 135                 140                 


Glu Gln Ser Pro Asp Asp Asp Ser Asp Gly Arg Cys Glu Leu Val Leu 
145                 150                 155                 160 


Arg Ala Gly Val Ala Asp Pro Arg Ala Ser Pro Gly Ala Gly Gly Gly 
                165                 170                 175     


Gly Ala Lys Ala Ala Glu Gly Cys Ser Asn Ala His Leu His Gly Gly 
            180                 185                 190         


Ala Ser Val Pro Pro Gly Gly Leu Gly Gly Gly Gly Gly Gly Gly Ser 
        195                 200                 205             


Ser Ser Gly Ser Ser Gly Gly Gly Gly Gly Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Lys Lys Ser Lys Glu Gln 
225                 230                 235                 240 


Lys Ala Leu Arg Leu Asn Ile Asn Ala Arg Glu Arg Arg Arg Met His 
                245                 250                 255     


Asp Leu Asn Asp Ala Leu Asp Glu Leu Arg Ala Val Ile Pro Tyr Ala 
            260                 265                 270         


His Ser Pro Ser Val Arg Lys Leu Ser Lys Ile Ala Xaa Leu Leu Leu 
        275                 280                 285             


Ala Lys Asn Tyr Ile Leu Met Gln Ala Gln Ala Leu Glu Glu Met Arg 
    290                 295                 300                 


Arg Leu Val Ala Tyr Leu Asn Gln Gly Gln Ala Ile Ser Ala Ala Ser 
305                 310                 315                 320 


Leu Pro Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu His Pro 
                325                 330                 335     


Ala Leu Gly Ala Tyr Glu Gln Ala Ala Gly Tyr Pro Phe Ser Ala Gly 
            340                 345                 350         


Leu Pro Pro Ala Ala Ser Cys Pro Glu Lys Cys Ala Leu Phe Asn Ser 
        355                 360                 365             


Val Ser Ser Ser Leu Cys Lys Gln Cys Xaa Glu Lys Pro 
    370                 375                 380     


<210> 4184
<211> 225
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<400> 4184
Met Ala Glu Leu Lys Ser Leu Ser Gly Asp Ala Tyr Leu Ala Leu Ser 
1               5                   10                  15      


His Gly Tyr Ala Ala Ala Ala Ala Gly Leu Ala Tyr Gly Ala Ala Arg 
            20                  25                  30          


Glu Pro Glu Ala Ala Arg Gly Tyr Gly Xaa Pro Gly Pro Gly Gly Asp 
        35                  40                  45              


Leu Pro Ala Ala Pro Ala Pro Arg Ala Pro Ala Gln Ala Ala Glu Ser 
    50                  55                  60                  


Ser Gly Glu Gln Ser Gly Asp Glu Asp Asp Ala Phe Glu Gln Arg Arg 
65                  70                  75                  80  


Arg Arg Arg Gly Pro Gly Ser Ala Ala Asp Gly Arg Arg Arg Pro Arg 
                85                  90                  95      


Glu Gln Arg Ser Leu Arg Leu Ser Ile Asn Ala Arg Glu Arg Arg Arg 
            100                 105                 110         


Met His Asp Leu Asn Asp Ala Leu Asp Gly Leu Arg Ala Val Ile Pro 
        115                 120                 125             


Tyr Ala His Ser Pro Ser Val Arg Lys Leu Ser Lys Ile Ala Xaa Leu 
    130                 135                 140                 


Leu Leu Ala Lys Asn Tyr Ile Leu Met Gln Ala Gln Ala Leu Asp Glu 
145                 150                 155                 160 


Met Arg Arg Leu Val Ala Phe Leu Asn Gln Gly Gln Gly Leu Ala Ala 
                165                 170                 175     


Pro Val Asn Ala Ala Pro Leu Xaa Pro Phe Gly Gln Ala Xaa Val Cys 
            180                 185                 190         


Pro Phe Ser Ala Gly Ala Ala Leu Gly Pro Cys Pro Asp Lys Cys Ala 
        195                 200                 205             


Ala Phe Ser Gly Xaa Pro Ser Ala Leu Cys Lys His Cys His Glu Lys 
    210                 215                 220                 


Pro 
225 


<210> 4185
<211> 241
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<400> 4185
Met Ser Ile Arg Pro Pro Gly Glu Pro Pro Ser Pro Gly Gly Ala Ala 
1               5                   10                  15      


Met Ala Glu Leu Lys Ser Leu Ser Gly Asp Ala Tyr Leu Ala Leu Ser 
            20                  25                  30          


His Gly Tyr Ala Ala Ala Ala Ala Gly Leu Ala Tyr Gly Ala Ala Arg 
        35                  40                  45              


Glu Pro Glu Ala Ala Arg Gly Tyr Gly Xaa Pro Gly Pro Gly Gly Asp 
    50                  55                  60                  


Leu Pro Ala Ala Pro Ala Pro Arg Ala Pro Ala Gln Ala Ala Glu Ser 
65                  70                  75                  80  


Ser Gly Glu Gln Ser Gly Asp Glu Asp Asp Ala Phe Glu Gln Arg Arg 
                85                  90                  95      


Arg Arg Arg Gly Pro Gly Ser Ala Ala Asp Gly Arg Arg Arg Pro Arg 
            100                 105                 110         


Glu Gln Arg Ser Leu Arg Leu Ser Ile Asn Ala Arg Glu Arg Arg Arg 
        115                 120                 125             


Met His Asp Leu Asn Asp Ala Leu Asp Gly Leu Arg Ala Val Ile Pro 
    130                 135                 140                 


Tyr Ala His Ser Pro Ser Val Arg Lys Leu Ser Lys Ile Ala Xaa Leu 
145                 150                 155                 160 


Leu Leu Ala Lys Asn Tyr Ile Leu Met Gln Ala Gln Ala Leu Asp Glu 
                165                 170                 175     


Met Arg Arg Leu Val Ala Phe Leu Asn Gln Gly Gln Gly Leu Ala Ala 
            180                 185                 190         


Pro Val Asn Ala Ala Pro Leu Xaa Pro Phe Gly Gln Ala Xaa Val Cys 
        195                 200                 205             


Pro Phe Ser Ala Gly Ala Ala Leu Gly Pro Cys Pro Asp Lys Cys Ala 
    210                 215                 220                 


Ala Phe Ser Gly Xaa Pro Ser Ala Leu Cys Lys His Cys His Glu Lys 
225                 230                 235                 240 


Pro 
    


<210> 4186
<211> 412
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<400> 4186
Met Glu Arg Ile Pro Ser Ala Gln Pro Pro Pro Ala Cys Leu Pro Lys 
1               5                   10                  15      


Ala Pro Gly Leu Glu His Gly Asp Leu Pro Gly Met Tyr Pro Ala His 
            20                  25                  30          


Met Tyr Gln Val Tyr Lys Ser Arg Arg Gly Ile Lys Arg Ser Glu Asp 
        35                  40                  45              


Ser Lys Glu Xaa Tyr Lys Leu Pro His Arg Leu Ile Glu Lys Lys Arg 
    50                  55                  60                  


Arg Asp Arg Ile Asn Glu Cys Ile Ala Gln Leu Lys Asp Leu Leu Pro 
65                  70                  75                  80  


Glu His Leu Lys Leu Xaa Xaa Leu Gly His Leu Glu Lys Ala Val Val 
                85                  90                  95      


Leu Glu Leu Xaa Leu Lys His Val Lys Ala Leu Xaa Asn Leu Ile Asp 
            100                 105                 110         


Gln Gln Gln Gln Lys Ile Ile Ala Leu Gln Ser Gly Leu Gln Ala Gly 
        115                 120                 125             


Glu Leu Ser Gly Arg Asn Val Glu Xaa Gly Gln Glu Met Phe Cys Ser 
    130                 135                 140                 


Gly Phe Gln Xaa Cys Ala Arg Glu Val Leu Gln Tyr Leu Ala Lys His 
145                 150                 155                 160 


Glu Asn Xaa Arg Asp Leu Lys Ser Ser Gln Leu Val Xaa His Leu His 
                165                 170                 175     


Arg Val Val Ser Glu Leu Leu Gln Gly Gly Xaa Ser Arg Lys Pro Ser 
            180                 185                 190         


Asp Pro Ala Pro Lys Val Met Asp Phe Lys Glu Lys Pro Ser Ser Pro 
        195                 200                 205             


Ala Lys Gly Ser Glu Gly Pro Gly Lys Asn Cys Val Pro Val Ile Gln 
    210                 215                 220                 


Arg Xaa Phe Ala His Ser Ser Gly Glu Gln Ser Gly Ser Asp Xaa Asp 
225                 230                 235                 240 


Xaa Asp Ser Gly Tyr Gly Gly Glu Ser Glu Lys Gly Asp Leu Arg Ser 
                245                 250                 255     


Glu Gln Pro Cys Phe Lys Ser Asp His Gly Arg Arg Phe Xaa Met Gly 
            260                 265                 270         


Glu Arg Ile Gly Ala Ile Lys Gln Glu Ser Glu Glu Pro Pro Xaa Lys 
        275                 280                 285             


Lys Asn Arg Met Gln Leu Ser Asp Asp Glu Gly His Phe Xaa Ser Ser 
    290                 295                 300                 


Asp Leu Ile Ser Ser Pro Phe Leu Gly Pro His Pro His Gln Pro Pro 
305                 310                 315                 320 


Phe Cys Leu Pro Phe Tyr Leu Ile Pro Pro Ser Ala Xaa Ala Tyr Leu 
                325                 330                 335     


Pro Met Leu Glu Lys Cys Trp Tyr Pro Xaa Ser Val Pro Val Leu Tyr 
            340                 345                 350         


Pro Gly Leu Asn Ala Ser Ala Ala Ala Leu Ser Ser Phe Met Asn Pro 
        355                 360                 365             


Asp Lys Ile Ser Ala Pro Leu Leu Met Pro Gln Arg Leu Pro Ser Pro 
    370                 375                 380                 


Leu Pro Ala His Pro Ser Val Asp Ser Ser Val Leu Leu Gln Ala Leu 
385                 390                 395                 400 


Lys Pro Ile Pro Pro Leu Asn Leu Glu Xaa Lys Asp 
                405                 410         


<210> 4187
<211> 482
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<400> 4187
Met Asp Glu Gly Ile Pro His Leu Gln Glu Arg Gln Leu Leu Glu His 
1               5                   10                  15      


Arg Asp Phe Ile Gly Leu Asp Tyr Ser Ser Leu Tyr Met Cys Lys Pro 
            20                  25                  30          


Lys Arg Ser Met Lys Arg Asp Asp Xaa Lys Asp Xaa Tyr Lys Leu Pro 
        35                  40                  45              


His Arg Leu Ile Glu Lys Lys Arg Arg Asp Arg Ile Asn Glu Cys Ile 
    50                  55                  60                  


Ala Gln Leu Lys Asp Leu Leu Pro Glu His Leu Lys Leu Xaa Xaa Leu 
65                  70                  75                  80  


Gly His Leu Glu Lys Ala Val Val Leu Glu Leu Xaa Leu Lys His Leu 
                85                  90                  95      


Lys Ala Leu Xaa Ala Leu Xaa Glu Gln Gln His Gln Lys Ile Ile Ala 
            100                 105                 110         


Leu Gln Asn Gly Glu Arg Ser Leu Lys Ser Pro Ile Gln Ser Asp Leu 
        115                 120                 125             


Asp Ala Phe His Ser Gly Phe Gln Xaa Cys Ala Lys Glu Val Leu Gln 
    130                 135                 140                 


Tyr Leu Ser Arg Phe Glu Ser Trp Xaa Pro Arg Glu Pro Arg Cys Val 
145                 150                 155                 160 


Gln Leu Ile Asn His Leu His Ala Val Ala Xaa Gln Phe Leu Pro Xaa 
                165                 170                 175     


Pro Gln Leu Leu Xaa Gln Gln Val Pro Leu Ser Lys Gly Xaa Gly Ala 
            180                 185                 190         


Pro Ser Ala Ala Gly Ser Ala Ala Ala Pro Cys Leu Glu Arg Ala Gly 
        195                 200                 205             


Gln Lys Leu Glu Pro Leu Ala Tyr Cys Val Pro Val Ile Gln Arg Xaa 
    210                 215                 220                 


Gln Pro Ser Ala Glu Leu Ala Ala Glu Asn Asp Xaa Asp Xaa Asp Ser 
225                 230                 235                 240 


Gly Tyr Gly Gly Glu Ala Glu Ala Arg Pro Asp Arg Glu Lys Gly Lys 
                245                 250                 255     


Gly Ala Gly Ala Ser Arg Val Xaa Ile Lys Gln Glu Pro Pro Gly Glu 
            260                 265                 270         


Asp Ser Pro Ala Pro Lys Arg Met Lys Leu Asp Ser Arg Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Pro Gly Gly Gly Ala Ala Ala Ala Ala Ala Ala Leu 
    290                 295                 300                 


Leu Gly Pro Asp Pro Ala Ala Ala Ala Ala Leu Leu Arg Pro Asp Ala 
305                 310                 315                 320 


Ala Leu Leu Ser Ser Leu Val Ala Phe Gly Gly Gly Gly Gly Ala Pro 
                325                 330                 335     


Phe Pro Gln Pro Ala Ala Ala Ala Ala Pro Phe Cys Leu Pro Phe Cys 
            340                 345                 350         


Phe Leu Ser Pro Ser Ala Ala Ala Ala Tyr Val Gln Pro Phe Leu Asp 
        355                 360                 365             


Lys Ser Gly Leu Glu Lys Tyr Leu Tyr Pro Ala Ala Ala Ala Ala Pro 
    370                 375                 380                 


Phe Pro Leu Leu Tyr Pro Gly Ile Pro Ala Pro Ala Ala Ala Ala Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Phe Pro Cys Leu Ser 
                405                 410                 415     


Ser Val Leu Ser Pro Pro Pro Glu Lys Ala Gly Ala Ala Ala Ala Xaa 
            420                 425                 430         


Leu Leu Pro His Glu Val Ala Pro Leu Gly Ala Pro His Pro Gln His 
        435                 440                 445             


Pro His Gly Arg Xaa His Leu Pro Phe Ala Gly Pro Arg Glu Pro Gly 
    450                 455                 460                 


Asn Pro Glu Ser Ser Ala Gln Glu Asp Pro Ser Gln Pro Gly Lys Glu 
465                 470                 475                 480 


Ala Pro 
        


<210> 4188
<211> 638
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<400> 4188
Met Phe Gly Ser Ser Arg Tyr Leu Gly Ser Ser Glu Gln Pro Arg Ala 
1               5                   10                  15      


Asn Ser Leu Gly Pro Ser Asp Arg Xaa Leu Val Leu Cys Ser Leu Val 
            20                  25                  30          


Glu Gly Glu Asp Lys Val Asn Pro Ser Glu Pro His Gly Leu Arg Met 
        35                  40                  45              


Glu Glu Lys Trp Leu Leu Lys Gly Lys Leu Arg Asn Gln Arg Asn Gln 
    50                  55                  60                  


Asn Lys Leu Leu Ser Pro Asn Lys Lys Gln Arg Lys Asn His Xaa Ser 
65                  70                  75                  80  


Lys Leu Gln Glu Leu Ala Leu Leu Leu Pro Ile Ala Leu Lys Xaa Gly 
                85                  90                  95      


Xaa Lys Lys Leu Xaa Lys Lys Glu Ile Leu Val His Val Leu Gln Tyr 
            100                 105                 110         


Ile Gln Tyr Leu Gln Arg Asn Ile Asp Ala Ala Lys Ala Leu Phe Lys 
        115                 120                 125             


Cys His Ile Xaa Xaa Gly Glu Gly Gly Leu Ala Gly Leu Gly Gln Lys 
    130                 135                 140                 


Pro Ala Trp Gly Pro Ala Arg Arg Arg Arg His Ser Xaa Pro Ser Ser 
145                 150                 155                 160 


Ser Pro Ser Ser Gln Lys Ser Cys Leu Gln Gly Ala Cys Gln Lys Pro 
                165                 170                 175     


Arg Lys Lys Lys Leu Xaa Gln Ala Ser Glu Ser Gln Xaa Arg Xaa Pro 
            180                 185                 190         


Lys Pro Arg Arg Ser Leu Ala Leu Asn Lys Pro Glu Lys Leu Val Ala 
        195                 200                 205             


Pro Ser Pro Asp Gln Lys Gly Ser Gly Xaa Gly Gly Xaa Xaa Xaa Pro 
    210                 215                 220                 


Pro Arg Cys Pro Asp Ser Cys Gly His Pro Arg Pro Ala Ser Ser Ser 
225                 230                 235                 240 


Pro Pro Gly Asp Arg Lys Gly Gly Gln Ser Gln Leu Xaa Leu Leu Asp 
                245                 250                 255     


Leu Ala Glu Asp Xaa Ile His Cys Asp Ile Ser Ser Cys Trp Cys Gln 
            260                 265                 270         


Gly Ser Val Gln Asp Asp Ala Pro Phe Pro Ala Leu Leu Ala Gln Glu 
        275                 280                 285             


Asp Val Ala Arg Ile His Phe Leu Asn Lys Xaa Gln Pro His Pro Arg 
    290                 295                 300                 


Gln Lys Leu Val Phe Tyr Asp Ser Ser Glu Asp Val Asp Lys Gly Ser 
305                 310                 315                 320 


Leu Asp Ala Asp Pro Trp Leu Pro Ala Trp Xaa Pro Glu Asn Ser Pro 
                325                 330                 335     


Gln Gly Ser Pro Leu Phe Leu Gly Pro Pro Gln Ile Asp Val Trp Ser 
            340                 345                 350         


Gly Xaa Gly His Pro Ser Glu Ile Leu Gly Leu Ser Pro Ser Leu Phe 
        355                 360                 365             


Ser Ser Pro Gly Lys Leu Leu Pro Asp Glu Ile Leu Glu Asp Asp Met 
    370                 375                 380                 


Glu Tyr Leu Xaa Gln Ala Ala Phe Phe Glu Glu Val Cys Leu Asp Leu 
385                 390                 395                 400 


Glu Ser Ser Pro Ser Ala Tyr Xaa Gln Glu Ala Pro Gln Glu Lys Asp 
                405                 410                 415     


Xaa Ala Ser Lys Ala Pro Lys Asp Pro Pro Glu Ser His Ser Leu His 
            420                 425                 430         


Arg Ser Ser Val Ser Leu Asp His Cys Tyr Leu Ser Leu Ser Gly Asn 
        435                 440                 445             


Ser Lys Ala Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
    450                 455                 460                 


Ser Glu Asp Ser Asp Ser Glu Pro Leu Trp Lys Gln Arg Glu Asp Met 
465                 470                 475                 480 


Gln Ala Asn Pro Val Gly Xaa Pro Gly Ser Ser Glu Glu Asp Glu Asp 
                485                 490                 495     


Xaa Xaa Trp Xaa Pro Xaa Arg Leu Ala Ser Pro Leu Leu Ala Ala Glu 
            500                 505                 510         


Lys Lys Ala Xaa Lys Gly Gln Val Ala Arg Ala Pro Val Lys Pro Lys 
        515                 520                 525             


Glu Lys Lys Lys Gly Pro Cys Pro Pro Gln Met Lys Lys Lys Cys Val 
    530                 535                 540                 


Asn Gly Phe Ile Met Phe Cys Arg Met Asn Arg Lys Gln Tyr Ile Arg 
545                 550                 555                 560 


Ser Cys Pro Gly Xaa Ala Ser Xaa Ala Ala Xaa Lys Glu Leu Ala Gln 
                565                 570                 575     


Leu Trp Arg Val Met Xaa Gln Gln Glu Arg Arg Pro Tyr Cys Xaa Lys 
            580                 585                 590         


Ala Arg Arg Phe Ser Arg Gln His Asn Arg Ile Val Lys Gln Asp Gly 
        595                 600                 605             


Ser Ser Ser Glu Ala Glu Asp Trp Glu Xaa Pro Lys Pro Phe Tyr Gln 
    610                 615                 620                 


Leu Leu Ala Glu Lys Ala Leu Pro Leu Pro Pro His Leu Gln 
625                 630                 635             


<210> 4189
<211> 974
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<400> 4189
Met Ala Ala Gln Gly Glu Pro Gly Tyr Leu Ala Ala Gln Ser Asp Pro 
1               5                   10                  15      


Gly Ser Asn Ser Glu Arg Ser Xaa Asp Ser Pro Val Pro Gly Ser Glu 
            20                  25                  30          


Asp Asp Leu Val Ala Gly Ala Xaa Leu His Ser Pro Glu Trp Ser Glu 
        35                  40                  45              


Glu Arg Phe Arg Val Asp Arg Lys Lys Leu Glu Ala Met Leu Gln Ala 
    50                  55                  60                  


Ala Ala Glu Gly Lys Gly Arg Ser Gly Glu Asp Phe Phe Gln Lys Ile 
65                  70                  75                  80  


Met Glu Glu Xaa Asn Xaa Gln Ile Ala Trp Pro Ser Lys Leu Lys Ile 
                85                  90                  95      


Gly Ala Lys Ser Lys Lys Asp Pro His Ile Lys Val Ser Gly Lys Lys 
            100                 105                 110         


Glu Asp Val Lys Glu Ala Lys Glu Met Ile Met Ser Val Leu Asp Xaa 
        115                 120                 125             


Lys Ser Asn Arg Val Xaa Leu Lys Met Asp Val Ser His Xaa Glu His 
    130                 135                 140                 


Ser His Val Ile Gly Lys Gly Gly Asn Asn Ile Lys Lys Val Met Glu 
145                 150                 155                 160 


Glu Xaa Gly Cys His Ile His Phe Pro Asp Ser Asn Arg Asn Asn Gln 
                165                 170                 175     


Ala Glu Lys Ser Asn Gln Val Ser Ile Ala Gly Gln Pro Ala Gly Val 
            180                 185                 190         


Glu Ser Ala Arg Val Arg Ile Arg Glu Leu Leu Pro Leu Val Leu Met 
        195                 200                 205             


Phe Glu Leu Pro Ile Ala Gly Ile Leu Gln Pro Val Pro Asp Pro Asn 
    210                 215                 220                 


Ser Pro Ser Ile Gln His Ile Ser Gln Xaa Tyr Asn Ile Ser Val Ser 
225                 230                 235                 240 


Phe Lys Gln Arg Ser Arg Met Tyr Gly Ala Xaa Val Ile Val Arg Gly 
                245                 250                 255     


Ser Gln Asn Asn Xaa Ser Ala Val Lys Glu Gly Xaa Ala Met Leu Leu 
            260                 265                 270         


Glu His Leu Ala Gly Ser Leu Ala Ser Ala Ile Pro Val Ser Xaa Gln 
        275                 280                 285             


Leu Asp Ile Ala Ala Gln His His Leu Phe Met Met Gly Arg Asn Gly 
    290                 295                 300                 


Ser Asn Ile Lys His Ile Met Gln Arg Xaa Gly Ala Gln Ile His Phe 
305                 310                 315                 320 


Pro Asp Pro Ser Asn Pro Gln Lys Lys Ser Xaa Val Tyr Leu Gln Gly 
                325                 330                 335     


Xaa Ile Glu Ser Val Cys Leu Ala Arg Gln Tyr Leu Met Gly Cys Leu 
            340                 345                 350         


Pro Leu Val Leu Met Phe Asp Met Lys Glu Glu Ile Glu Val Asp Pro 
        355                 360                 365             


Gln Phe Ile Ala Gln Leu Met Glu Gln Leu Asp Val Phe Ile Ser Ile 
    370                 375                 380                 


Lys Pro Lys Pro Lys Gln Pro Ser Lys Ser Val Ile Val Lys Ser Val 
385                 390                 395                 400 


Glu Arg Asn Ala Leu Asn Met Tyr Glu Ala Arg Lys Cys Leu Leu Gly 
                405                 410                 415     


Leu Glu Ser Ser Gly Val Xaa Ile Ala Xaa Ser Pro Ser Pro Ala Ser 
            420                 425                 430         


Cys Pro Ala Gly Leu Ala Cys Pro Ser Leu Asp Ile Leu Ala Ser Ala 
        435                 440                 445             


Gly Leu Gly Leu Xaa Gly Leu Gly Leu Leu Gly Pro Xaa Xaa Leu Ser 
    450                 455                 460                 


Leu Asn Xaa Ser Xaa Xaa Pro Asn Ser Leu Leu Asn Ala Leu Asn Ser 
465                 470                 475                 480 


Ser Val Ser Pro Leu Gln Ser Pro Ser Ser Gly Xaa Pro Ser Pro Xaa 
                485                 490                 495     


Leu Trp Ala Pro Pro Leu Ala Asn Xaa Ser Ser Ala Xaa Gly Phe Ser 
            500                 505                 510         


Ala Ile Pro His Leu Met Ile Pro Ser Xaa Ala Gln Ala Xaa Leu Xaa 
        515                 520                 525             


Asn Ile Leu Leu Ser Gly Val Pro Xaa Tyr Gly His Xaa Ala Pro Ser 
    530                 535                 540                 


Pro Pro Pro Gly Leu Xaa Pro Val Asp Val His Ile Asn Ser Met Gln 
545                 550                 555                 560 


Xaa Glu Gly Lys Lys Ile Ser Ala Ala Leu Asn Gly His Ala Gln Ser 
                565                 570                 575     


Pro Asp Ile Lys Tyr Gly Ala Ile Ser Xaa Ser Ser Leu Gly Glu Lys 
            580                 585                 590         


Val Leu Ser Ala Asn His Gly Asp Pro Ser Ile Gln Xaa Ser Gly Ser 
        595                 600                 605             


Glu Gln Xaa Ser Pro Lys Ser Ser Pro Xaa Glu Gly Cys Asn Asp Ala 
    610                 615                 620                 


Phe Val Glu Val Gly Met Pro Arg Ser Pro Ser His Ser Gly Asn Ala 
625                 630                 635                 640 


Gly Asp Leu Lys Gln Met Met Cys Pro Ser Lys Val Ser Cys Ala Lys 
                645                 650                 655     


Arg Gln Xaa Val Glu Leu Leu Gln Gly Xaa Lys Asn Ser His Leu His 
            660                 665                 670         


Ser Xaa Asp Arg Leu Leu Ser Asp Pro Glu Leu Ser Ala Xaa Glu Ser 
        675                 680                 685             


Pro Leu Ala Asp Lys Lys Ala Pro Gly Ser Glu Arg Ala Ala Glu Arg 
    690                 695                 700                 


Ala Ala Ala Ala Gln Gln Asn Ser Glu Arg Ala His Leu Ala Pro Arg 
705                 710                 715                 720 


Ser Ser Tyr Val Asn Met Gln Ala Phe Asp Tyr Glu Gln Lys Lys Leu 
                725                 730                 735     


Leu Ala Xaa Lys Ala Met Leu Lys Lys Pro Val Val Xaa Glu Val Arg 
            740                 745                 750         


Xaa Pro Xaa Asn Xaa Trp Ser Gly Leu Gly Phe Ser Lys Ser Met Pro 
        755                 760                 765             


Ala Glu Xaa Ile Lys Glu Leu Arg Arg Ala Asn His Val Ser Tyr Lys 
    770                 775                 780                 


Pro Xaa Met Xaa Xaa Xaa Tyr Glu Gly Ser Ser Met Ser Leu Ser Arg 
785                 790                 795                 800 


Ser Asn Ser Arg Glu His Leu Gly Gly Gly Ser Glu Ser Asp Asn Trp 
                805                 810                 815     


Arg Asp Arg Asn Gly Ile Gly Pro Gly Ser His Ser Glu Phe Ala Ala 
            820                 825                 830         


Ser Ile Gly Ser Pro Lys Arg Lys Gln Asn Lys Ser Xaa Glu His Tyr 
        835                 840                 845             


Leu Ser Ser Ser Asn Tyr Met Asp Cys Ile Ser Ser Leu Xaa Gly Ser 
    850                 855                 860                 


Asn Gly Cys Asn Leu Asn Ser Ser Phe Lys Gly Ser Asp Leu Pro Glu 
865                 870                 875                 880 


Leu Phe Ser Lys Leu Gly Leu Gly Lys Tyr Xaa Asp Val Phe Gln Gln 
                885                 890                 895     


Gln Glu Ile Asp Leu Gln Xaa Phe Leu Xaa Leu Xaa Asp Gln Asp Leu 
            900                 905                 910         


Lys Glu Leu Gly Ile Xaa Xaa Phe Gly Ala Arg Arg Lys Met Leu Leu 
        915                 920                 925             


Ala Ile Ser Glu Leu Asn Lys Asn Arg Arg Lys Leu Phe Glu Ser Pro 
    930                 935                 940                 


Asn Ala Arg Xaa Ser Phe Leu Glu Gly Gly Ala Ser Gly Arg Leu Pro 
945                 950                 955                 960 


Arg Gln Tyr His Ser Asp Ile Ala Ser Val Ser Gly Arg Trp 
                965                 970                 


<210> 4190
<211> 506
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<400> 4190
Met Glu Gln Leu Asp Val Phe Ile Ser Ile Lys Pro Lys Pro Lys Gln 
1               5                   10                  15      


Pro Ser Lys Ser Val Ile Val Lys Ser Val Glu Arg Asn Ala Leu Asn 
            20                  25                  30          


Met Tyr Glu Ala Arg Lys Cys Leu Leu Gly Leu Glu Ser Ser Gly Val 
        35                  40                  45              


Xaa Ile Ala Xaa Ser Pro Ser Pro Ala Ser Cys Pro Ala Gly Leu Ala 
    50                  55                  60                  


Cys Pro Ser Leu Asp Ile Leu Ala Ser Ala Gly Leu Gly Leu Xaa Gly 
65                  70                  75                  80  


Leu Gly Leu Leu Gly Pro Xaa Xaa Leu Ser Leu Asn Xaa Ser Xaa Xaa 
                85                  90                  95      


Pro Asn Ser Leu Leu Asn Ala Leu Asn Ser Ser Val Ser Pro Leu Gln 
            100                 105                 110         


Ser Pro Ser Ser Gly Xaa Pro Ser Pro Xaa Leu Trp Ala Pro Pro Leu 
        115                 120                 125             


Ala Asn Xaa Ser Ser Ala Xaa Gly Phe Ser Ala Ile Pro His Leu Met 
    130                 135                 140                 


Ile Pro Ser Xaa Ala Gln Ala Xaa Leu Xaa Asn Ile Leu Leu Ser Gly 
145                 150                 155                 160 


Val Pro Xaa Tyr Gly His Xaa Ala Pro Ser Pro Pro Pro Gly Leu Xaa 
                165                 170                 175     


Pro Val Asp Val His Ile Asn Ser Met Gln Xaa Glu Gly Lys Lys Ile 
            180                 185                 190         


Ser Ala Ala Leu Asn Gly His Ala Gln Ser Pro Asp Ile Lys Tyr Gly 
        195                 200                 205             


Ala Ile Ser Xaa Ser Ser Leu Gly Glu Lys Val Leu Ser Ala Asn His 
    210                 215                 220                 


Gly Asp Pro Ser Ile Gln Xaa Ser Gly Ser Glu Gln Xaa Ser Pro Lys 
225                 230                 235                 240 


Ser Ser Pro Xaa Glu Gly Cys Asn Asp Ala Phe Val Glu Val Gly Met 
                245                 250                 255     


Pro Arg Ser Pro Ser His Ser Gly Asn Ala Gly Asp Leu Lys Gln Met 
            260                 265                 270         


Met Cys Pro Ser Lys Val Ser Cys Ala Lys Arg Gln Xaa Val Glu Leu 
        275                 280                 285             


Leu Gln Gly Xaa Lys Asn Ser His Leu His Ser Xaa Asp Arg Leu Leu 
    290                 295                 300                 


Ser Asp Pro Glu Leu Ser Ala Xaa Glu Ser Pro Leu Ala Asp Lys Lys 
305                 310                 315                 320 


Ala Pro Gly Ser Glu Arg Ala Ala Glu Arg Ala Ala Ala Ala Gln Gln 
                325                 330                 335     


Asn Ser Glu Arg Ala His Leu Ala Pro Arg Ser Ser Tyr Val Asn Met 
            340                 345                 350         


Gln Ala Phe Asp Tyr Glu Gln Lys Lys Leu Leu Ala Xaa Lys Ala Met 
        355                 360                 365             


Leu Lys Lys Pro Val Val Xaa Glu Val Arg Xaa Pro Xaa Asn Xaa Trp 
    370                 375                 380                 


Ser Gly Leu Gly Phe Ser Lys Ser Met Pro Ala Glu Xaa Ile Lys Glu 
385                 390                 395                 400 


Leu Arg Arg Ala Asn His Val Ser Tyr Lys Pro Xaa Met Xaa Xaa Xaa 
                405                 410                 415     


Tyr Glu Gly Ser Ser Met Ser Leu Ser Arg Ser Asn Ser Arg Glu His 
            420                 425                 430         


Leu Gly Gly Gly Ser Glu Ser Asp Asn Trp Arg Asp Arg Asn Gly Ile 
        435                 440                 445             


Gly Pro Gly Ser His Ser Glu Phe Ala Ala Ser Ile Gly Ser Pro Lys 
    450                 455                 460                 


Arg Lys Gln Asn Lys Ser Ser Glu Arg Cys Val Leu Cys Xaa Leu Leu 
465                 470                 475                 480 


Gly Ile Pro Arg Leu Glu Cys Val Tyr Leu Gly Trp Ser Ile Xaa Asp 
                485                 490                 495     


Cys Gly Leu Ser Asp Phe Lys Cys Leu Val 
            500                 505     


<210> 4191
<211> 827
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<400> 4191
Met Ala Ala Glu Glu Val Leu Gln Xaa Val Asp His Tyr Lys Xaa Glu 
1               5                   10                  15      


Ile Glu Arg Leu Xaa Lys Glu Leu Xaa Glu Xaa Xaa His Glu Lys Ile 
            20                  25                  30          


Gln Ala Ala Glu Tyr Gly Leu Val Val Leu Glu Glu Lys Leu Xaa Leu 
        35                  40                  45              


Lys Gln Gln Tyr Asp Glu Leu Glu Ala Glu Tyr Asp Ser Leu Lys Gln 
    50                  55                  60                  


Glu Leu Glu Gln Leu Lys Glu Ala Phe Gly Gln Ser Phe Ser Ile His 
65                  70                  75                  80  


Arg Lys Val Ala Glu Asp Gly Glu Xaa Arg Glu Glu Xaa Leu Leu Gln 
                85                  90                  95      


Glu Ser Ala Ser Lys Glu Ala Tyr Tyr Leu Gly Lys Ile Leu Glu Met 
            100                 105                 110         


Gln Asn Glu Leu Lys Gln Ser Arg Ala Val Val Xaa Asn Val Gln Ala 
        115                 120                 125             


Glu Asn Glu Arg Leu Xaa Ala Val Val Gln Asp Leu Lys Glu Asn Asn 
    130                 135                 140                 


Glu Met Val Glu Leu Gln Arg Ile Arg Met Lys Asp Glu Ile Arg Glu 
145                 150                 155                 160 


Tyr Lys Phe Arg Glu Ala Arg Leu Leu Gln Asp Tyr Xaa Glu Leu Glu 
                165                 170                 175     


Glu Glu Asn Ile Xaa Leu Gln Lys Leu Val Ser Xaa Leu Lys Gln Asn 
            180                 185                 190         


Gln Val Glu Tyr Glu Gly Leu Lys His Glu Ile Lys Arg Phe Glu Glu 
        195                 200                 205             


Glu Xaa Val Leu Leu Asn Ser Gln Leu Glu Asp Ala Ile Arg Leu Lys 
    210                 215                 220                 


Glu Ile Ala Glu His Gln Leu Glu Glu Ala Leu Glu Xaa Leu Lys Asn 
225                 230                 235                 240 


Glu Arg Glu Gln Lys Asn Asn Leu Arg Lys Glu Leu Ser Gln Tyr Ile 
                245                 250                 255     


Ser Leu Asn Asp Asn His Ile Ser Ile Ser Val Asp Gly Leu Lys Phe 
            260                 265                 270         


Ala Glu Asp Gly Ser Glu Pro Asn Asn Asp Asp Lys Met Asn Gly His 
        275                 280                 285             


Ile His Gly Pro Leu Val Lys Leu Asn Gly Asp Tyr Arg Xaa Pro Xaa 
    290                 295                 300                 


Leu Arg Lys Gly Glu Ser Leu Asn Pro Val Ser Asp Leu Phe Ser Glu 
305                 310                 315                 320 


Leu Asn Ile Ser Glu Ile Gln Lys Leu Lys Gln Gln Leu Met Gln Val 
                325                 330                 335     


Glu Arg Glu Lys Ala Ile Leu Leu Ala Asn Leu Gln Glu Ser Gln Xaa 
            340                 345                 350         


Gln Leu Glu His Xaa Lys Gly Ala Leu Xaa Glu Gln His Glu Arg Val 
        355                 360                 365             


His Arg Leu Xaa Glu His Val Asn Ala Met Arg Gly Leu Gln Ser Ser 
    370                 375                 380                 


Lys Glu Leu Lys Ala Glu Leu Asp Gly Glu Lys Gly Arg Asp Ser Gly 
385                 390                 395                 400 


Glu Glu Ala His Asp Tyr Glu Val Asp Ile Asn Gly Leu Glu Ile Leu 
                405                 410                 415     


Glu Cys Lys Tyr Arg Val Ala Val Xaa Glu Val Ile Asp Leu Lys Ala 
            420                 425                 430         


Glu Ile Lys Ala Leu Lys Glu Lys Tyr Asn Lys Ser Val Glu Asn Tyr 
        435                 440                 445             


Xaa Asp Glu Lys Ala Lys Tyr Glu Ser Lys Ile Gln Met Tyr Asp Glu 
    450                 455                 460                 


Gln Val Xaa Ser Leu Glu Lys Xaa Xaa Lys Glu Ser Gly Glu Lys Met 
465                 470                 475                 480 


Ala His Met Glu Lys Glu Leu Gln Lys Met Xaa Ser Ile Ala Asn Glu 
                485                 490                 495     


Asn His Ser Xaa Leu Asn Xaa Ala Gln Asp Glu Leu Val Xaa Phe Ser 
            500                 505                 510         


Glu Glu Leu Ala Gln Leu Tyr His His Val Cys Leu Cys Asn Asn Glu 
        515                 520                 525             


Xaa Pro Asn Arg Val Met Leu Asp Tyr Tyr Arg Gln Ser Arg Val Xaa 
    530                 535                 540                 


Arg Ser Gly Ser Leu Lys Gly Pro Asp Asp Pro Arg Gly Leu Leu Ser 
545                 550                 555                 560 


Pro Arg Leu Ala Arg Arg Gly Val Ser Ser Pro Val Glu Xaa Arg Xaa 
                565                 570                 575     


Ser Ser Glu Pro Val Ala Lys Glu Ser Xaa Glu Ala Ser Lys Glu Pro 
            580                 585                 590         


Ser Pro Xaa Lys Xaa Pro Xaa Ile Ser Pro Val Ile Xaa Ala Pro Pro 
        595                 600                 605             


Ser Ser Pro Val Leu Asp Xaa Ser Asp Ile Arg Lys Glu Pro Met Asn 
    610                 615                 620                 


Ile Tyr Asn Leu Asn Ala Ile Ile Arg Asp Gln Ile Lys His Leu Gln 
625                 630                 635                 640 


Lys Ala Val Asp Arg Ser Leu Gln Leu Ser Arg Gln Arg Ala Ala Ala 
                645                 650                 655     


Arg Glu Leu Ala Pro Met Ile Asp Lys Asp Lys Glu Ala Leu Met Glu 
            660                 665                 670         


Glu Ile Leu Lys Leu Lys Ser Leu Leu Ser Xaa Lys Arg Glu Gln Ile 
        675                 680                 685             


Ala Xaa Leu Arg Ala Val Leu Lys Ala Asn Lys Gln Xaa Ala Glu Val 
    690                 695                 700                 


Ala Leu Ala Asn Leu Lys Asn Lys Tyr Glu Asn Glu Lys Ala Met Val 
705                 710                 715                 720 


Xaa Glu Xaa Met Xaa Lys Leu Arg Asn Glu Leu Lys Ala Leu Lys Glu 
                725                 730                 735     


Asp Ala Ala Xaa Phe Ser Ser Leu Arg Ala Met Phe Ala Xaa Arg Cys 
            740                 745                 750         


Asp Glu Tyr Val Xaa Gln Leu Asp Glu Met Gln Arg Gln Leu Ala Ala 
        755                 760                 765             


Ala Glu Asp Glu Lys Lys Xaa Leu Asn Xaa Leu Leu Arg Met Ala Ile 
    770                 775                 780                 


Gln Gln Lys Leu Ala Leu Xaa Gln Arg Leu Glu Asp Leu Glu Phe Asp 
785                 790                 795                 800 


His Glu Gln Ser Arg Arg Ser Lys Gly Lys Leu Gly Lys Ser Lys Ile 
                805                 810                 815     


Gly Ser Pro Lys Xaa Ile Phe Xaa Phe Pro Leu 
            820                 825         


<210> 4192
<211> 835
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<400> 4192
Met Ala Ala Glu Glu Val Leu Gln Xaa Val Asp His Tyr Lys Xaa Glu 
1               5                   10                  15      


Ile Glu Arg Leu Xaa Lys Glu Leu Xaa Glu Xaa Xaa His Glu Lys Ile 
            20                  25                  30          


Gln Ala Ala Glu Tyr Gly Leu Val Val Leu Glu Glu Lys Leu Xaa Leu 
        35                  40                  45              


Lys Gln Gln Tyr Asp Glu Leu Glu Ala Glu Tyr Asp Ser Leu Lys Gln 
    50                  55                  60                  


Glu Leu Glu Gln Leu Lys Glu Ala Phe Gly Gln Ser Phe Ser Ile His 
65                  70                  75                  80  


Arg Lys Val Ala Glu Asp Gly Glu Xaa Arg Glu Glu Xaa Leu Leu Gln 
                85                  90                  95      


Glu Ser Ala Ser Lys Glu Ala Tyr Tyr Leu Gly Lys Ile Leu Glu Met 
            100                 105                 110         


Gln Asn Glu Leu Lys Gln Ser Arg Ala Val Val Xaa Asn Val Gln Ala 
        115                 120                 125             


Glu Asn Glu Arg Leu Xaa Ala Val Val Gln Asp Leu Lys Glu Asn Asn 
    130                 135                 140                 


Glu Met Val Glu Leu Gln Arg Ile Arg Met Lys Asp Glu Ile Arg Glu 
145                 150                 155                 160 


Tyr Lys Phe Arg Glu Ala Arg Leu Leu Gln Asp Tyr Xaa Glu Leu Glu 
                165                 170                 175     


Glu Glu Asn Ile Xaa Leu Gln Lys Leu Val Ser Xaa Leu Lys Gln Asn 
            180                 185                 190         


Gln Val Glu Tyr Glu Gly Leu Lys His Glu Ile Lys Arg Phe Glu Glu 
        195                 200                 205             


Glu Xaa Val Leu Leu Asn Ser Gln Leu Glu Asp Ala Ile Arg Leu Lys 
    210                 215                 220                 


Glu Ile Ala Glu His Gln Leu Glu Glu Ala Leu Glu Xaa Leu Lys Asn 
225                 230                 235                 240 


Glu Arg Glu Gln Lys Asn Asn Leu Arg Lys Glu Leu Ser Gln Tyr Ile 
                245                 250                 255     


Ser Leu Asn Asp Asn His Ile Ser Ile Ser Val Asp Gly Leu Lys Phe 
            260                 265                 270         


Ala Glu Asp Gly Ser Glu Pro Asn Asn Asp Asp Lys Met Asn Gly His 
        275                 280                 285             


Ile His Gly Pro Leu Val Lys Leu Asn Gly Asp Tyr Arg Xaa Pro Xaa 
    290                 295                 300                 


Leu Arg Lys Gly Glu Ser Leu Asn Pro Val Ser Asp Leu Phe Ser Glu 
305                 310                 315                 320 


Leu Asn Ile Ser Glu Ile Gln Lys Leu Lys Gln Gln Leu Met Gln Val 
                325                 330                 335     


Glu Arg Glu Lys Ala Ile Leu Leu Ala Asn Leu Gln Glu Ser Gln Xaa 
            340                 345                 350         


Gln Leu Glu His Xaa Lys Gly Ala Leu Xaa Glu Gln His Glu Arg Val 
        355                 360                 365             


His Arg Leu Xaa Glu His Val Asn Ala Met Arg Gly Leu Gln Ser Ser 
    370                 375                 380                 


Lys Glu Leu Lys Ala Glu Leu Asp Gly Glu Lys Gly Arg Asp Ser Gly 
385                 390                 395                 400 


Glu Glu Ala His Asp Tyr Glu Val Asp Ile Asn Gly Leu Glu Ile Leu 
                405                 410                 415     


Glu Cys Lys Tyr Arg Val Ala Val Xaa Glu Val Ile Asp Leu Lys Ala 
            420                 425                 430         


Glu Ile Lys Ala Leu Lys Glu Lys Tyr Asn Lys Ser Val Glu Asn Tyr 
        435                 440                 445             


Xaa Asp Glu Lys Ala Lys Tyr Glu Ser Lys Ile Gln Met Tyr Asp Glu 
    450                 455                 460                 


Gln Val Xaa Ser Leu Glu Lys Xaa Xaa Lys Glu Ser Gly Glu Lys Met 
465                 470                 475                 480 


Ala His Met Glu Lys Glu Leu Gln Lys Met Xaa Ser Ile Ala Asn Glu 
                485                 490                 495     


Asn His Ser Xaa Leu Asn Xaa Ala Gln Asp Glu Leu Val Xaa Phe Ser 
            500                 505                 510         


Glu Glu Leu Ala Gln Leu Tyr His His Val Cys Leu Cys Asn Asn Glu 
        515                 520                 525             


Xaa Pro Asn Arg Val Met Leu Asp Tyr Tyr Arg Gln Ser Arg Val Xaa 
    530                 535                 540                 


Arg Ser Gly Ser Leu Lys Gly Pro Asp Asp Pro Arg Gly Leu Leu Ser 
545                 550                 555                 560 


Pro Arg Leu Ala Arg Arg Gly Val Ser Ser Pro Val Glu Xaa Arg Xaa 
                565                 570                 575     


Ser Ser Glu Pro Val Ala Lys Glu Ser Xaa Glu Ala Ser Lys Glu Pro 
            580                 585                 590         


Ser Pro Xaa Lys Xaa Pro Xaa Ile Ser Pro Val Ile Xaa Ala Pro Pro 
        595                 600                 605             


Ser Ser Pro Val Leu Asp Xaa Ser Asp Ile Arg Lys Glu Pro Met Asn 
    610                 615                 620                 


Ile Tyr Asn Leu Asn Ala Ile Ile Arg Asp Gln Ile Lys His Leu Gln 
625                 630                 635                 640 


Lys Ala Val Asp Arg Ser Leu Gln Leu Ser Arg Gln Arg Ala Ala Ala 
                645                 650                 655     


Arg Glu Leu Ala Pro Met Ile Asp Lys Asp Lys Glu Ala Leu Met Glu 
            660                 665                 670         


Glu Ile Leu Lys Leu Lys Ser Leu Leu Ser Xaa Lys Arg Glu Gln Ile 
        675                 680                 685             


Ala Xaa Leu Arg Ala Val Leu Lys Ala Asn Lys Gln Xaa Ala Glu Val 
    690                 695                 700                 


Ala Leu Ala Asn Leu Lys Asn Lys Tyr Glu Asn Glu Lys Ala Met Val 
705                 710                 715                 720 


Xaa Glu Xaa Met Xaa Lys Leu Arg Asn Glu Leu Lys Ala Leu Lys Glu 
                725                 730                 735     


Asp Ala Ala Xaa Phe Ser Ser Leu Arg Ala Met Phe Ala Xaa Arg Cys 
            740                 745                 750         


Asp Glu Tyr Val Xaa Gln Leu Asp Glu Met Gln Arg Gln Leu Ala Ala 
        755                 760                 765             


Ala Glu Asp Glu Lys Lys Xaa Leu Asn Xaa Leu Leu Arg Met Ala Ile 
    770                 775                 780                 


Gln Gln Lys Leu Ala Leu Xaa Gln Arg Leu Glu Asp Leu Glu Phe Asp 
785                 790                 795                 800 


His Glu Gln Ser Arg Arg Ser Lys Gly Lys Leu Gly Lys Ser Lys Ile 
                805                 810                 815     


Gly Ser Pro Lys Ile Val Ser Ser Leu Leu Pro Pro Tyr Arg His Ser 
            820                 825                 830         


Ala His Asn 
        835 


<210> 4193
<211> 975
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<400> 4193
Met Ala Ala Glu Glu Val Leu Gln Xaa Val Asp His Tyr Lys Xaa Glu 
1               5                   10                  15      


Ile Glu Arg Leu Xaa Lys Glu Leu Xaa Glu Xaa Xaa His Glu Lys Ile 
            20                  25                  30          


Gln Ala Ala Glu Tyr Gly Leu Val Val Leu Glu Glu Lys Leu Xaa Leu 
        35                  40                  45              


Lys Gln Gln Tyr Asp Glu Leu Glu Ala Glu Tyr Asp Ser Leu Lys Gln 
    50                  55                  60                  


Glu Leu Glu Gln Leu Lys Glu Ala Phe Gly Gln Ser Phe Ser Ile His 
65                  70                  75                  80  


Arg Lys Val Ala Glu Asp Gly Glu Xaa Arg Glu Glu Xaa Leu Leu Gln 
                85                  90                  95      


Glu Ser Ala Ser Lys Glu Ala Tyr Tyr Leu Gly Lys Ile Leu Glu Met 
            100                 105                 110         


Gln Asn Glu Leu Lys Gln Ser Arg Ala Val Val Xaa Asn Val Gln Ala 
        115                 120                 125             


Glu Asn Glu Arg Leu Xaa Ala Val Val Gln Asp Leu Lys Glu Asn Asn 
    130                 135                 140                 


Glu Met Val Glu Leu Gln Arg Ile Arg Met Lys Asp Glu Ile Arg Glu 
145                 150                 155                 160 


Tyr Lys Phe Arg Glu Ala Arg Leu Leu Gln Asp Tyr Xaa Glu Leu Glu 
                165                 170                 175     


Glu Glu Asn Ile Xaa Leu Gln Lys Leu Val Ser Xaa Leu Lys Gln Asn 
            180                 185                 190         


Gln Val Glu Tyr Glu Gly Leu Lys His Glu Ile Lys Arg Phe Glu Glu 
        195                 200                 205             


Glu Xaa Val Leu Leu Asn Ser Gln Leu Glu Asp Ala Ile Arg Leu Lys 
    210                 215                 220                 


Glu Ile Ala Glu His Gln Leu Glu Glu Ala Leu Glu Xaa Leu Lys Asn 
225                 230                 235                 240 


Glu Arg Glu Gln Lys Asn Asn Leu Arg Lys Glu Leu Ser Gln Tyr Ile 
                245                 250                 255     


Ser Leu Asn Asp Asn His Ile Ser Ile Ser Val Asp Gly Leu Lys Phe 
            260                 265                 270         


Ala Glu Asp Gly Ser Glu Pro Asn Asn Asp Asp Lys Met Asn Gly His 
        275                 280                 285             


Ile His Gly Pro Leu Val Lys Leu Asn Gly Asp Tyr Arg Xaa Pro Xaa 
    290                 295                 300                 


Leu Arg Lys Gly Glu Ser Leu Asn Pro Val Ser Asp Leu Phe Ser Glu 
305                 310                 315                 320 


Leu Asn Ile Ser Glu Ile Gln Lys Leu Lys Gln Gln Leu Met Gln Val 
                325                 330                 335     


Glu Arg Glu Lys Ala Ile Leu Leu Ala Asn Leu Gln Glu Ser Gln Xaa 
            340                 345                 350         


Gln Leu Glu His Xaa Lys Gly Ala Leu Xaa Glu Gln His Glu Arg Val 
        355                 360                 365             


His Arg Leu Xaa Glu His Val Asn Ala Met Arg Gly Leu Gln Ser Ser 
    370                 375                 380                 


Lys Glu Leu Lys Ala Glu Leu Asp Gly Glu Lys Gly Arg Asp Ser Gly 
385                 390                 395                 400 


Glu Glu Ala His Asp Tyr Glu Val Asp Ile Asn Gly Leu Glu Ile Leu 
                405                 410                 415     


Glu Cys Lys Tyr Arg Val Ala Val Xaa Glu Val Ile Asp Leu Lys Ala 
            420                 425                 430         


Glu Ile Lys Ala Leu Lys Glu Lys Tyr Asn Lys Ser Val Glu Asn Tyr 
        435                 440                 445             


Xaa Asp Glu Lys Ala Lys Tyr Glu Ser Lys Ile Gln Met Tyr Asp Glu 
    450                 455                 460                 


Gln Val Xaa Ser Leu Glu Lys Xaa Xaa Lys Glu Ser Gly Glu Lys Met 
465                 470                 475                 480 


Ala His Met Glu Lys Glu Leu Gln Lys Met Xaa Ser Ile Ala Asn Glu 
                485                 490                 495     


Asn His Ser Xaa Leu Asn Xaa Ala Gln Asp Glu Leu Val Xaa Phe Ser 
            500                 505                 510         


Glu Glu Leu Ala Gln Leu Tyr His His Val Cys Leu Cys Asn Asn Glu 
        515                 520                 525             


Xaa Pro Asn Arg Val Met Leu Asp Tyr Tyr Arg Gln Ser Arg Val Xaa 
    530                 535                 540                 


Arg Ser Gly Ser Leu Lys Gly Pro Asp Asp Pro Arg Gly Leu Leu Ser 
545                 550                 555                 560 


Pro Arg Leu Ala Arg Arg Gly Val Ser Ser Pro Val Glu Xaa Arg Xaa 
                565                 570                 575     


Ser Ser Glu Pro Val Ala Lys Glu Ser Xaa Glu Ala Ser Lys Glu Pro 
            580                 585                 590         


Ser Pro Xaa Lys Xaa Pro Xaa Ile Ser Pro Val Ile Xaa Ala Pro Pro 
        595                 600                 605             


Ser Ser Pro Val Leu Asp Xaa Ser Asp Ile Arg Lys Glu Pro Met Asn 
    610                 615                 620                 


Ile Tyr Asn Leu Asn Ala Ile Ile Arg Asp Gln Ile Lys His Leu Gln 
625                 630                 635                 640 


Lys Ala Val Asp Arg Ser Leu Gln Leu Ser Arg Gln Arg Ala Ala Ala 
                645                 650                 655     


Arg Glu Leu Ala Pro Met Ile Asp Lys Asp Lys Glu Ala Leu Met Glu 
            660                 665                 670         


Glu Ile Leu Lys Leu Lys Ser Leu Leu Ser Xaa Lys Arg Glu Gln Ile 
        675                 680                 685             


Ala Xaa Leu Arg Ala Val Leu Lys Ala Asn Lys Gln Xaa Ala Glu Val 
    690                 695                 700                 


Ala Leu Ala Asn Leu Lys Asn Lys Tyr Glu Asn Glu Lys Ala Met Val 
705                 710                 715                 720 


Xaa Glu Xaa Met Xaa Lys Leu Arg Asn Glu Leu Lys Ala Leu Lys Glu 
                725                 730                 735     


Asp Ala Ala Xaa Phe Ser Ser Leu Arg Ala Met Phe Ala Xaa Arg Cys 
            740                 745                 750         


Asp Glu Tyr Val Xaa Gln Leu Asp Glu Met Gln Arg Gln Leu Ala Ala 
        755                 760                 765             


Ala Glu Asp Glu Lys Lys Xaa Leu Asn Xaa Leu Leu Arg Met Ala Ile 
    770                 775                 780                 


Gln Gln Lys Leu Ala Leu Xaa Gln Arg Leu Glu Asp Leu Glu Phe Asp 
785                 790                 795                 800 


His Glu Gln Ser Arg Arg Ser Lys Gly Lys Leu Gly Lys Ser Lys Ile 
                805                 810                 815     


Gly Ser Pro Lys Val Ser Gly Glu Ala Ser Val Xaa Val Pro Xaa Ile 
            820                 825                 830         


Asp Xaa Tyr Leu Leu His Ser Gln Gly Pro Gln Xaa Pro Asn Ile Arg 
        835                 840                 845             


Val Ser Ser Gly Xaa Gln Arg Lys Arg Gln Phe Ser Pro Ser Leu Cys 
    850                 855                 860                 


Asp Gln Ser Arg Pro Arg Xaa Ser Gly Ala Ser Tyr Leu Gln Asn Leu 
865                 870                 875                 880 


Leu Arg Val Pro Pro Asp Pro Xaa Ser Xaa Glu Ser Phe Leu Leu Lys 
                885                 890                 895     


Gly Pro Pro Ser Met Ser Glu Phe Ile Gln Gly His Arg Leu Ser Lys 
            900                 905                 910         


Glu Lys Arg Leu Xaa Val Ala Pro Pro Asp Cys Gln Gln Pro Ala Ala 
        915                 920                 925             


Ser Val Pro Pro Gln Cys Ser Gln Leu Ala Gly Arg Gln Asp Cys Pro 
    930                 935                 940                 


Xaa Val Ser Pro Asp Xaa Ala Leu Pro Glu Glu Gln Pro His Ser Ser 
945                 950                 955                 960 


Ser Gln Cys Ala Pro Leu His Cys Leu Ser Lys Pro Pro His Pro 
                965                 970                 975 


<210> 4194
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<400> 4194
Met Ala Ala Glu Glu Val Leu Gln Xaa Val Asp His Tyr Lys Xaa Glu 
1               5                   10                  15      


Ile Glu Arg Leu Xaa Lys Glu Leu Xaa Glu Xaa Xaa His Glu Lys Ile 
            20                  25                  30          


Gln Ala Ala Glu Tyr Gly Leu Val Val Leu Glu Glu Lys Leu Xaa Leu 
        35                  40                  45              


Lys Gln Gln Tyr Asp Glu Leu Glu Ala Glu Tyr Asp Ser Leu Lys Gln 
    50                  55                  60                  


Glu Leu Glu Gln Leu Lys Glu Gly Pro Leu Leu Leu Lys Asp Val Ile 
65                  70                  75                  80  


Tyr Asp Ile Leu Asn Gln Leu Ala Phe Gln Phe Ser Val 
                85                  90              


<210> 4195
<211> 79
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<400> 4195
Met Ala Ala Glu Glu Val Leu Gln Xaa Val Asp His Tyr Lys Xaa Glu 
1               5                   10                  15      


Ile Glu Arg Leu Xaa Lys Glu Leu Xaa Glu Xaa Xaa His Glu Lys Ile 
            20                  25                  30          


Gln Ala Ala Glu Tyr Gly Leu Val Val Leu Glu Glu Lys Leu Xaa Leu 
        35                  40                  45              


Lys Gln Gln Tyr Asp Glu Leu Glu Ala Glu Tyr Asp Ser Leu Lys Gln 
    50                  55                  60                  


Glu Leu Glu Gln Leu Lys Glu Gly Pro Leu Leu Val Arg Glu Asp 
65                  70                  75                  


<210> 4196
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<400> 4196
Met Ala Ala Glu Glu Val Leu Gln Xaa Val Asp His Tyr Lys Xaa Glu 
1               5                   10                  15      


Ile Glu Arg Leu Xaa Lys Glu Leu Xaa Glu Xaa Xaa His Glu Lys Ile 
            20                  25                  30          


Gln Ala Ala Glu Tyr Gly Leu Val Val Leu Glu Glu Lys Leu Xaa Leu 
        35                  40                  45              


Lys Gln Gln Tyr Asp Glu Leu Glu Ala Glu Tyr Asp Ser Leu Lys Gln 
    50                  55                  60                  


Glu Leu Glu Gln Leu Lys Glu Val Ser Cys Leu Ser Pro Leu Pro Phe 
65                  70                  75                  80  


Leu Ala Leu Xaa Pro Pro Xaa Arg Lys Ala His Ser Ser 
                85                  90              


<210> 4197
<211> 173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 4197
Xaa Ala Glu Val Ala Leu Ala Asn Leu Lys Asn Lys Tyr Glu Asn Glu 
1               5                   10                  15      


Lys Ala Met Val Xaa Glu Xaa Met Xaa Lys Leu Arg Asn Glu Leu Lys 
            20                  25                  30          


Ala Leu Lys Glu Asp Ala Ala Xaa Phe Ser Ser Leu Arg Ala Met Phe 
        35                  40                  45              


Ala Xaa Arg Cys Asp Glu Tyr Val Xaa Gln Leu Asp Glu Met Gln Arg 
    50                  55                  60                  


Gln Leu Ala Ala Ala Glu Asp Glu Lys Lys Xaa Leu Asn Xaa Leu Leu 
65                  70                  75                  80  


Arg Met Ala Ile Gln Gln Lys Leu Ala Leu Xaa Gln Arg Leu Glu Asp 
                85                  90                  95      


Leu Glu Phe Asp His Glu Gln Ser Arg Arg Ser Lys Gly Lys Leu Gly 
            100                 105                 110         


Lys Ser Lys Ile Gly Ser Pro Lys Val Ser Gly Glu Ala Ser Val Xaa 
        115                 120                 125             


Val Pro Xaa Ile Asp Xaa Tyr Leu Leu His Ser Gln Gly Pro Gln Xaa 
    130                 135                 140                 


Pro Asn Ile Arg Val Ser Ser Gly Xaa Gln Arg Lys Arg Tyr Ala Cys 
145                 150                 155                 160 


Ser Asp Leu His Ser Xaa Val Gln Trp Pro Asp Phe Ser 
                165                 170             


<210> 4198
<211> 69
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<400> 4198
Xaa Ser Arg Gln Arg Ala Ala Ala Arg Glu Leu Ala Pro Met Ile Asp 
1               5                   10                  15      


Lys Asp Lys Glu Ala Leu Met Glu Glu Ile Leu Lys Leu Lys Ser Leu 
            20                  25                  30          


Leu Ser Xaa Lys Arg Glu Gln Ile Ala Xaa Leu Arg Ala Val Leu Lys 
        35                  40                  45              


Ala Asn Lys Gln Ala Gln Cys Leu Leu Met Lys Ser Val Asn Ala Tyr 
    50                  55                  60                  


Glu Ala Pro Ser Ile 
65                  


<210> 4199
<211> 241
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<400> 4199
Met Cys Ser Gly Ala Gly Val Met Met Ala Arg Trp Ala Ala Arg Gly 
1               5                   10                  15      


Arg Ala Gly Trp Arg Ser Xaa Val Arg Ile Leu Ser Pro Leu Gly His 
            20                  25                  30          


Cys Glu Pro Gly Val Ser Arg Ser Cys Arg Ala Ala Gln Ala Met Asp 
        35                  40                  45              


Cys Glu Val Asn Asn Gly Ser Ser Leu Arg Asp Glu Cys Ile Xaa Asn 
    50                  55                  60                  


Leu Leu Val Phe Gly Phe Leu Gln Ser Cys Ser Asp Asn Ser Phe Arg 
65                  70                  75                  80  


Arg Glu Leu Asp Ala Leu Gly His Glu Leu Pro Val Leu Ala Pro Gln 
                85                  90                  95      


Trp Glu Gly Tyr Asp Glu Leu Gln Xaa Asp Gly Asn Arg Ser Ser His 
            100                 105                 110         


Ser Arg Leu Gly Arg Ile Glu Ala Asp Ser Glu Ser Gln Glu Asp Ile 
        115                 120                 125             


Ile Arg Asn Ile Ala Arg His Leu Ala Gln Val Gly Asp Ser Met Asp 
    130                 135                 140                 


Arg Ser Ile Pro Pro Gly Leu Val Asn Gly Leu Ala Leu Gln Leu Arg 
145                 150                 155                 160 


Asn Xaa Ser Arg Ser Glu Glu Asp Arg Asn Arg Asp Leu Ala Xaa Ala 
                165                 170                 175     


Leu Glu Gln Leu Leu Gln Ala Tyr Pro Arg Asp Met Glu Lys Glu Lys 
            180                 185                 190         


Xaa Met Leu Val Leu Ala Leu Leu Leu Ala Lys Lys Val Ala Ser His 
        195                 200                 205             


Xaa Pro Ser Leu Leu Arg Asp Val Phe His Xaa Xaa Val Asn Phe Ile 
    210                 215                 220                 


Asn Gln Asn Leu Arg Xaa Tyr Val Arg Ser Leu Ala Arg Asn Gly Met 
225                 230                 235                 240 


Asp 
    


<210> 4200
<211> 195
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<400> 4200
Met Asp Cys Glu Val Asn Asn Gly Ser Ser Leu Arg Asp Glu Cys Ile 
1               5                   10                  15      


Xaa Asn Leu Leu Val Phe Gly Phe Leu Gln Ser Cys Ser Asp Asn Ser 
            20                  25                  30          


Phe Arg Arg Glu Leu Asp Ala Leu Gly His Glu Leu Pro Val Leu Ala 
        35                  40                  45              


Pro Gln Trp Glu Gly Tyr Asp Glu Leu Gln Xaa Asp Gly Asn Arg Ser 
    50                  55                  60                  


Ser His Ser Arg Leu Gly Arg Ile Glu Ala Asp Ser Glu Ser Gln Glu 
65                  70                  75                  80  


Asp Ile Ile Arg Asn Ile Ala Arg His Leu Ala Gln Val Gly Asp Ser 
                85                  90                  95      


Met Asp Arg Ser Ile Pro Pro Gly Leu Val Asn Gly Leu Ala Leu Gln 
            100                 105                 110         


Leu Arg Asn Xaa Ser Arg Ser Glu Glu Asp Arg Asn Arg Asp Leu Ala 
        115                 120                 125             


Xaa Ala Leu Glu Gln Leu Leu Gln Ala Tyr Pro Arg Asp Met Glu Lys 
    130                 135                 140                 


Glu Lys Xaa Met Leu Val Leu Ala Leu Leu Leu Ala Lys Lys Val Ala 
145                 150                 155                 160 


Ser His Xaa Pro Ser Leu Leu Arg Asp Val Phe His Xaa Xaa Val Asn 
                165                 170                 175     


Phe Ile Asn Gln Asn Leu Arg Xaa Tyr Val Arg Ser Leu Ala Arg Asn 
            180                 185                 190         


Gly Met Asp 
        195 


<210> 4201
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 4201
Met Asp Cys Glu Val Asn Asn Gly Ser Ser Leu Arg Asp Glu Cys Ile 
1               5                   10                  15      


Xaa Asn Leu Leu Val Phe Gly Phe Leu Gln Ser Cys Ser Asp Asn Ser 
            20                  25                  30          


Phe Arg Arg Glu Leu Asp Ala Leu Gly His Glu Leu Pro Val Leu Ala 
        35                  40                  45              


Pro Gln Trp Glu Gly Tyr Asp Glu Leu Gln Xaa Asp Gly Asn Arg Ser 
    50                  55                  60                  


Ser His Ser Arg Leu Gly Arg Ile Glu Ala Gly Ala Ser Asp Asn Asn 
65                  70                  75                  80  


Xaa Ala Ser Ala Glu Glu Glu Xaa Glu Ala Ala Gly Ser Val Ala Val 
                85                  90                  95      


Glu Arg Gly Leu His Gly Ala Ala Xaa Val Ile Leu Lys Val Lys Lys 
            100                 105                 110         


Xaa Ser Ser Gly Ile Leu Pro Gly Xaa Ser Pro Arg Ser Gly Xaa Ala 
        115                 120                 125             


Trp Xaa Val Ala Ser Leu Arg Ala Trp 
    130                 135         


<210> 4202
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<400> 4202
Met Asp Cys Glu Val Asn Asn Gly Ser Ser Leu Arg Asp Glu Cys Ile 
1               5                   10                  15      


Xaa Asn Leu Leu Val Phe Gly Phe Leu Gln Ser Cys Ser Asp Asn Ser 
            20                  25                  30          


Phe Arg Arg Glu Leu Asp Ala Leu Gly His Glu Leu Pro Val Leu Ala 
        35                  40                  45              


Pro Gln Trp Glu Gly Tyr Asp Glu Leu Gln Xaa Asp Gly Asn Arg Ser 
    50                  55                  60                  


Ser His Ser Arg Leu Gly Arg Ile Glu Ala Gly Ala Ser Asp Asn Asn 
65                  70                  75                  80  


Xaa Ala Ser Ala Glu Glu Glu Xaa Glu Ala Ala Gly Ser Val Ala Val 
                85                  90                  95      


Glu Arg Gly Leu His Gly Ala Ala Xaa Val Val Leu Gly Gln Gly Gln 
            100                 105                 110         


His Gly Gly Cys Ala Pro Glu Glu Glu Asp 
        115                 120         


<210> 4203
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 4203
Met Asp Arg Ser Ile Pro Pro Gly Leu Val Asn Gly Leu Ala Leu Gln 
1               5                   10                  15      


Leu Arg Asn Xaa Ser Arg Ser Glu Glu Asp Arg Asn Arg Asp Leu Ala 
            20                  25                  30          


Xaa Ala Leu Glu Gln Leu Leu Gln Ala Tyr Pro Arg Asp Met Glu Lys 
        35                  40                  45              


Glu Lys Xaa Met Leu Val Leu Ala Leu Leu Leu Ala Lys Lys Val Ala 
    50                  55                  60                  


Ser His Xaa Pro Ser Leu Leu Arg Asp Val Phe His Xaa Xaa Val Asn 
65                  70                  75                  80  


Phe Ile Asn Gln Asn Leu Arg Xaa Tyr Val Arg Ser Leu Ala Arg Asn 
                85                  90                  95      


Gly Met Asp 
            


<210> 4204
<211> 139
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<400> 4204
Met Ala Leu Phe Gln Gln Leu Xaa Cys Val Leu Pro Ile Leu Asp Asn 
1               5                   10                  15      


Leu Leu Lys Ala Asn Val Ile Asn Lys Gln Glu His Asp Ile Ile Lys 
            20                  25                  30          


Gln Lys Xaa Gln Ile Pro Leu Gln Ala Arg Glu Leu Ile Asp Xaa Ile 
        35                  40                  45              


Leu Val Lys Gly Asn Ala Ala Ala Asn Ile Phe Lys Asn Cys Leu Lys 
    50                  55                  60                  


Glu Ile Asp Ser Xaa Leu Tyr Lys Asn Leu Phe Val Asp Lys Asn Met 
65                  70                  75                  80  


Lys Tyr Ile Pro Xaa Glu Asp Val Ser Gly Leu Ser Leu Glu Glu Gln 
                85                  90                  95      


Leu Arg Arg Leu Gln Glu Glu Arg Xaa Cys Lys Val Cys Met Asp Lys 
            100                 105                 110         


Glu Val Ser Val Val Phe Ile Pro Cys Gly His Leu Val Val Cys Gln 
        115                 120                 125             


Glu Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile 
    130                 135                 


<210> 4205
<211> 79
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<400> 4205
Met Glu Cys Asn Phe Val Ala Val Glu Asp Ile Ser Ser Ser Arg Xaa 
1               5                   10                  15      


Asn Pro Tyr Ser Tyr Ala Met Ser Xaa Glu Glu Ala Arg Phe Leu Xaa 
            20                  25                  30          


Tyr His Met Trp Pro Leu Xaa Phe Leu Ser Pro Ser Glu Leu Ala Arg 
        35                  40                  45              


Ala Gly Phe Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala 
    50                  55                  60                  


Cys Gly Gly Lys Leu Ser Asn Trp Glu Pro Lys Asp Asp Ala Met 
65                  70                  75                  


<210> 4206
<211> 149
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<400> 4206
Met Glu Asp Ser Xaa Ile Leu Ser Asp Trp Xaa Asn Ser Asn Lys Gln 
1               5                   10                  15      


Lys Met Lys Tyr Asp Phe Ser Cys Glu Leu Tyr Arg Met Ser Xaa Tyr 
            20                  25                  30          


Ser Xaa Phe Pro Ala Gly Val Pro Val Ser Glu Arg Ser Leu Ala Arg 
        35                  40                  45              


Ala Gly Phe Tyr Tyr Xaa Gly Val Asn Asp Lys Val Lys Cys Phe Cys 
    50                  55                  60                  


Cys Gly Leu Met Leu Asp Asn Trp Lys Leu Gly Asp Ser Pro Ile Gln 
65                  70                  75                  80  


Lys His Lys Gln Leu Tyr Pro Ser Cys Ser Phe Ile Gln Asn Leu Val 
                85                  90                  95      


Ser Ala Ser Leu Gly Ser Xaa Ser Lys Asn Xaa Ser Pro Met Arg Asn 
            100                 105                 110         


Ser Phe Ala His Ser Leu Ser Pro Xaa Leu Glu His Ser Ser Leu Phe 
        115                 120                 125             


Ser Gly Ser Tyr Ser Ser Leu Ser Pro Asn Pro Leu Asn Ser Arg Ala 
    130                 135                 140                 


Val Glu Asp Ile Ser 
145                 


<210> 4207
<211> 597
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<400> 4207
Met Glu Asp Ser Xaa Ile Leu Ser Asp Trp Xaa Asn Ser Asn Lys Gln 
1               5                   10                  15      


Lys Met Lys Tyr Asp Phe Ser Cys Glu Leu Tyr Arg Met Ser Xaa Tyr 
            20                  25                  30          


Ser Xaa Phe Pro Ala Gly Val Pro Val Ser Glu Arg Ser Leu Ala Arg 
        35                  40                  45              


Ala Gly Phe Tyr Tyr Xaa Gly Val Asn Asp Lys Val Lys Cys Phe Cys 
    50                  55                  60                  


Cys Gly Leu Met Leu Asp Asn Trp Lys Leu Gly Asp Ser Pro Ile Gln 
65                  70                  75                  80  


Lys His Lys Gln Leu Tyr Pro Ser Cys Ser Phe Ile Gln Asn Leu Val 
                85                  90                  95      


Ser Ala Ser Leu Gly Ser Xaa Ser Lys Asn Xaa Ser Pro Met Arg Asn 
            100                 105                 110         


Ser Phe Ala His Ser Leu Ser Pro Xaa Leu Glu His Ser Ser Leu Phe 
        115                 120                 125             


Ser Gly Ser Tyr Ser Ser Leu Ser Pro Asn Pro Leu Asn Ser Arg Ala 
    130                 135                 140                 


Val Glu Asp Ile Ser Ser Ser Arg Xaa Asn Pro Tyr Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Xaa Glu Glu Ala Arg Phe Leu Xaa Tyr His Met Trp Pro Leu Xaa 
                165                 170                 175     


Phe Leu Ser Pro Ser Glu Leu Ala Arg Ala Gly Phe Tyr Tyr Ile Gly 
            180                 185                 190         


Pro Gly Asp Arg Val Ala Cys Phe Ala Cys Gly Gly Lys Leu Ser Asn 
        195                 200                 205             


Trp Glu Pro Lys Asp Asp Ala Met Ser Glu His Arg Arg His Phe Pro 
    210                 215                 220                 


Asn Cys Pro Phe Leu Glu Asn Ser Leu Glu Xaa Leu Arg Phe Ser Ile 
225                 230                 235                 240 


Ser Asn Leu Ser Met Gln Xaa His Ala Ala Arg Met Arg Xaa Phe Met 
                245                 250                 255     


Tyr Trp Pro Ser Ser Val Pro Val Gln Pro Glu Gln Leu Ala Ser Ala 
            260                 265                 270         


Gly Phe Tyr Tyr Val Gly Arg Asn Asp Asp Val Lys Cys Phe Cys Cys 
        275                 280                 285             


Asp Gly Gly Leu Arg Cys Trp Glu Ser Gly Asp Asp Pro Trp Val Glu 
    290                 295                 300                 


His Ala Lys Trp Phe Pro Arg Cys Glu Phe Leu Ile Arg Met Lys Gly 
305                 310                 315                 320 


Gln Glu Phe Val Asp Glu Ile Gln Gly Arg Tyr Pro His Leu Leu Glu 
                325                 330                 335     


Gln Leu Leu Ser Xaa Ser Asp Xaa Xaa Gly Glu Glu Asn Ala Asp Pro 
            340                 345                 350         


Pro Ile Ile His Phe Gly Pro Gly Glu Ser Ser Ser Glu Asp Ala Val 
        355                 360                 365             


Met Met Asn Xaa Pro Val Val Lys Ser Ala Leu Glu Met Gly Phe Asn 
    370                 375                 380                 


Arg Asp Leu Val Lys Gln Xaa Val Gln Ser Lys Ile Leu Xaa Xaa Gly 
385                 390                 395                 400 


Glu Asn Tyr Lys Xaa Val Asn Asp Ile Val Ser Ala Leu Leu Asn Ala 
                405                 410                 415     


Glu Asp Glu Lys Arg Glu Glu Glu Lys Glu Lys Gln Ala Glu Glu Met 
            420                 425                 430         


Ala Ser Asp Asp Leu Ser Leu Ile Arg Lys Asn Arg Met Ala Leu Phe 
        435                 440                 445             


Gln Gln Leu Xaa Cys Val Leu Pro Ile Leu Asp Asn Leu Leu Lys Ala 
    450                 455                 460                 


Asn Val Ile Asn Lys Gln Glu His Asp Ile Ile Lys Gln Lys Xaa Gln 
465                 470                 475                 480 


Ile Pro Leu Gln Ala Arg Glu Leu Ile Asp Xaa Ile Leu Val Lys Gly 
                485                 490                 495     


Asn Ala Ala Ala Asn Ile Phe Lys Asn Cys Leu Lys Glu Ile Asp Ser 
            500                 505                 510         


Xaa Leu Tyr Lys Asn Leu Phe Val Asp Lys Asn Met Lys Tyr Ile Pro 
        515                 520                 525             


Xaa Glu Asp Val Ser Gly Leu Ser Leu Glu Glu Gln Leu Arg Arg Leu 
    530                 535                 540                 


Gln Glu Glu Arg Xaa Cys Lys Val Cys Met Asp Lys Glu Val Ser Val 
545                 550                 555                 560 


Val Phe Ile Pro Cys Gly His Leu Val Val Cys Gln Glu Cys Ala Pro 
                565                 570                 575     


Ser Leu Arg Lys Cys Pro Ile Cys Arg Gly Ile Ile Lys Gly Xaa Val 
            580                 585                 590         


Arg Xaa Phe Leu Ser 
        595         


<210> 4208
<211> 534
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<400> 4208
Met His Lys Xaa Ala Ser Gln Arg Leu Phe Pro Gly Pro Ser Tyr Gln 
1               5                   10                  15      


Asn Ile Lys Ser Ile Met Glu Asp Ser Xaa Ile Leu Ser Asp Trp Xaa 
            20                  25                  30          


Asn Ser Asn Lys Gln Lys Met Lys Tyr Asp Phe Ser Cys Glu Leu Tyr 
        35                  40                  45              


Arg Met Ser Xaa Tyr Ser Xaa Phe Pro Ala Gly Val Pro Val Ser Glu 
    50                  55                  60                  


Arg Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Xaa Gly Val Asn Asp Lys 
65                  70                  75                  80  


Val Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Leu Gly 
                85                  90                  95      


Asp Ser Pro Ile Gln Lys His Lys Gln Leu Tyr Pro Ser Cys Ser Phe 
            100                 105                 110         


Ile Gln Asn Leu Val Ser Ala Ser Leu Gly Ser Xaa Ser Lys Asn Xaa 
        115                 120                 125             


Ser Pro Met Arg Asn Ser Phe Ala His Ser Leu Ser Pro Xaa Leu Glu 
    130                 135                 140                 


His Ser Ser Leu Phe Ser Gly Ser Tyr Ser Ser Leu Ser Pro Asn Pro 
145                 150                 155                 160 


Leu Asn Ser Arg Ala Val Glu Asp Ile Ser Ser Ser Arg Xaa Asn Pro 
                165                 170                 175     


Tyr Ser Tyr Ala Met Ser Xaa Glu Glu Ala Arg Phe Leu Xaa Tyr His 
            180                 185                 190         


Met Trp Pro Leu Xaa Phe Leu Ser Pro Ser Glu Leu Ala Arg Ala Gly 
        195                 200                 205             


Phe Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys Gly 
    210                 215                 220                 


Gly Lys Leu Ser Asn Trp Glu Pro Lys Asp Asp Ala Met Ser Glu His 
225                 230                 235                 240 


Arg Arg His Phe Pro Asn Cys Pro Phe Leu Glu Asn Ser Leu Glu Xaa 
                245                 250                 255     


Leu Arg Phe Ser Ile Ser Asn Leu Ser Met Gln Xaa His Ala Ala Arg 
            260                 265                 270         


Met Arg Xaa Phe Met Tyr Trp Pro Ser Ser Val Pro Val Gln Pro Glu 
        275                 280                 285             


Gln Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Arg Asn Asp Asp Val 
    290                 295                 300                 


Lys Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser Gly Asp 
305                 310                 315                 320 


Asp Pro Trp Val Glu His Ala Lys Trp Phe Pro Arg Cys Glu Phe Leu 
                325                 330                 335     


Ile Arg Met Lys Gly Gln Glu Phe Val Asp Glu Ile Gln Gly Arg Tyr 
            340                 345                 350         


Pro His Leu Leu Glu Gln Leu Leu Ser Xaa Ser Asp Xaa Xaa Gly Glu 
        355                 360                 365             


Glu Asn Ala Asp Pro Pro Ile Ile His Phe Gly Pro Gly Glu Ser Ser 
    370                 375                 380                 


Ser Glu Asp Ala Val Met Met Asn Xaa Pro Val Val Lys Ser Ala Leu 
385                 390                 395                 400 


Glu Met Gly Phe Asn Arg Asp Leu Val Lys Gln Xaa Val Gln Ser Lys 
                405                 410                 415     


Ile Leu Xaa Xaa Gly Glu Asn Tyr Lys Xaa Val Asn Asp Ile Val Ser 
            420                 425                 430         


Ala Leu Leu Asn Ala Glu Asp Glu Lys Arg Glu Glu Glu Lys Glu Lys 
        435                 440                 445             


Gln Ala Glu Glu Met Ala Ser Asp Asp Leu Ser Leu Ile Arg Lys Asn 
    450                 455                 460                 


Arg Met Ala Leu Phe Gln Gln Leu Xaa Cys Val Leu Pro Ile Leu Asp 
465                 470                 475                 480 


Asn Leu Leu Lys Ala Asn Val Ile Asn Lys Gln Glu His Asp Ile Ile 
                485                 490                 495     


Lys Gln Lys Xaa Gln Ile Pro Leu Gln Ala Arg Glu Leu Ile Asp Xaa 
            500                 505                 510         


Ile Leu Val Lys Gly Asn Ala Ala Ala Asn Ile Phe Lys Asn Cys Leu 
        515                 520                 525             


Lys Val Lys Gln Arg Phe 
    530                 


<210> 4209
<211> 618
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<400> 4209
Met His Lys Xaa Ala Ser Gln Arg Leu Phe Pro Gly Pro Ser Tyr Gln 
1               5                   10                  15      


Asn Ile Lys Ser Ile Met Glu Asp Ser Xaa Ile Leu Ser Asp Trp Xaa 
            20                  25                  30          


Asn Ser Asn Lys Gln Lys Met Lys Tyr Asp Phe Ser Cys Glu Leu Tyr 
        35                  40                  45              


Arg Met Ser Xaa Tyr Ser Xaa Phe Pro Ala Gly Val Pro Val Ser Glu 
    50                  55                  60                  


Arg Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Xaa Gly Val Asn Asp Lys 
65                  70                  75                  80  


Val Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Leu Gly 
                85                  90                  95      


Asp Ser Pro Ile Gln Lys His Lys Gln Leu Tyr Pro Ser Cys Ser Phe 
            100                 105                 110         


Ile Gln Asn Leu Val Ser Ala Ser Leu Gly Ser Xaa Ser Lys Asn Xaa 
        115                 120                 125             


Ser Pro Met Arg Asn Ser Phe Ala His Ser Leu Ser Pro Xaa Leu Glu 
    130                 135                 140                 


His Ser Ser Leu Phe Ser Gly Ser Tyr Ser Ser Leu Ser Pro Asn Pro 
145                 150                 155                 160 


Leu Asn Ser Arg Ala Val Glu Asp Ile Ser Ser Ser Arg Xaa Asn Pro 
                165                 170                 175     


Tyr Ser Tyr Ala Met Ser Xaa Glu Glu Ala Arg Phe Leu Xaa Tyr His 
            180                 185                 190         


Met Trp Pro Leu Xaa Phe Leu Ser Pro Ser Glu Leu Ala Arg Ala Gly 
        195                 200                 205             


Phe Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys Gly 
    210                 215                 220                 


Gly Lys Leu Ser Asn Trp Glu Pro Lys Asp Asp Ala Met Ser Glu His 
225                 230                 235                 240 


Arg Arg His Phe Pro Asn Cys Pro Phe Leu Glu Asn Ser Leu Glu Xaa 
                245                 250                 255     


Leu Arg Phe Ser Ile Ser Asn Leu Ser Met Gln Xaa His Ala Ala Arg 
            260                 265                 270         


Met Arg Xaa Phe Met Tyr Trp Pro Ser Ser Val Pro Val Gln Pro Glu 
        275                 280                 285             


Gln Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Arg Asn Asp Asp Val 
    290                 295                 300                 


Lys Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser Gly Asp 
305                 310                 315                 320 


Asp Pro Trp Val Glu His Ala Lys Trp Phe Pro Arg Cys Glu Phe Leu 
                325                 330                 335     


Ile Arg Met Lys Gly Gln Glu Phe Val Asp Glu Ile Gln Gly Arg Tyr 
            340                 345                 350         


Pro His Leu Leu Glu Gln Leu Leu Ser Xaa Ser Asp Xaa Xaa Gly Glu 
        355                 360                 365             


Glu Asn Ala Asp Pro Pro Ile Ile His Phe Gly Pro Gly Glu Ser Ser 
    370                 375                 380                 


Ser Glu Asp Ala Val Met Met Asn Xaa Pro Val Val Lys Ser Ala Leu 
385                 390                 395                 400 


Glu Met Gly Phe Asn Arg Asp Leu Val Lys Gln Xaa Val Gln Ser Lys 
                405                 410                 415     


Ile Leu Xaa Xaa Gly Glu Asn Tyr Lys Xaa Val Asn Asp Ile Val Ser 
            420                 425                 430         


Ala Leu Leu Asn Ala Glu Asp Glu Lys Arg Glu Glu Glu Lys Glu Lys 
        435                 440                 445             


Gln Ala Glu Glu Met Ala Ser Asp Asp Leu Ser Leu Ile Arg Lys Asn 
    450                 455                 460                 


Arg Met Ala Leu Phe Gln Gln Leu Xaa Cys Val Leu Pro Ile Leu Asp 
465                 470                 475                 480 


Asn Leu Leu Lys Ala Asn Val Ile Asn Lys Gln Glu His Asp Ile Ile 
                485                 490                 495     


Lys Gln Lys Xaa Gln Ile Pro Leu Gln Ala Arg Glu Leu Ile Asp Xaa 
            500                 505                 510         


Ile Leu Val Lys Gly Asn Ala Ala Ala Asn Ile Phe Lys Asn Cys Leu 
        515                 520                 525             


Lys Glu Ile Asp Ser Xaa Leu Tyr Lys Asn Leu Phe Val Asp Lys Asn 
    530                 535                 540                 


Met Lys Tyr Ile Pro Xaa Glu Asp Val Ser Gly Leu Ser Leu Glu Glu 
545                 550                 555                 560 


Gln Leu Arg Arg Leu Gln Glu Glu Arg Xaa Cys Lys Val Cys Met Asp 
                565                 570                 575     


Lys Glu Val Ser Val Val Phe Ile Pro Cys Gly His Leu Val Val Cys 
            580                 585                 590         


Gln Glu Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg Gly Ile 
        595                 600                 605             


Ile Lys Gly Xaa Val Arg Xaa Phe Leu Ser 
    610                 615             


<210> 4210
<211> 183
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<400> 4210
Met Lys Gly Gln Glu Phe Val Asp Glu Ile Gln Gly Arg Tyr Pro His 
1               5                   10                  15      


Leu Leu Glu Gln Leu Leu Ser Xaa Ser Asp Xaa Xaa Gly Glu Glu Asn 
            20                  25                  30          


Ala Asp Pro Pro Ile Ile His Phe Gly Pro Gly Glu Ser Ser Ser Glu 
        35                  40                  45              


Asp Ala Val Met Met Asn Xaa Pro Val Val Lys Ser Ala Leu Glu Met 
    50                  55                  60                  


Gly Phe Asn Arg Asp Leu Val Lys Gln Xaa Val Gln Ser Lys Ile Leu 
65                  70                  75                  80  


Xaa Xaa Gly Glu Asn Tyr Lys Xaa Val Asn Asp Ile Val Ser Ala Leu 
                85                  90                  95      


Leu Asn Ala Glu Asp Glu Lys Arg Glu Glu Glu Lys Glu Lys Gln Ala 
            100                 105                 110         


Glu Glu Met Ala Ser Asp Asp Leu Ser Leu Ile Arg Lys Asn Arg Met 
        115                 120                 125             


Ala Leu Phe Gln Gln Leu Xaa Cys Val Leu Pro Ile Leu Asp Asn Leu 
    130                 135                 140                 


Leu Lys Ala Asn Val Ile Asn Lys Gln Glu His Asp Ile Ile Lys Gln 
145                 150                 155                 160 


Lys Xaa Gln Ile Pro Leu Gln Ala Arg Glu Leu Ile Asp Xaa Ile Leu 
                165                 170                 175     


Val Lys Gly Asn Ala Ala Ala 
            180             


<210> 4211
<211> 569
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<400> 4211
Met Ser Xaa Tyr Ser Xaa Phe Pro Ala Gly Val Pro Val Ser Glu Arg 
1               5                   10                  15      


Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Xaa Gly Val Asn Asp Lys Val 
            20                  25                  30          


Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Leu Gly Asp 
        35                  40                  45              


Ser Pro Ile Gln Lys His Lys Gln Leu Tyr Pro Ser Cys Ser Phe Ile 
    50                  55                  60                  


Gln Asn Leu Val Ser Ala Ser Leu Gly Ser Xaa Ser Lys Asn Xaa Ser 
65                  70                  75                  80  


Pro Met Arg Asn Ser Phe Ala His Ser Leu Ser Pro Xaa Leu Glu His 
                85                  90                  95      


Ser Ser Leu Phe Ser Gly Ser Tyr Ser Ser Leu Ser Pro Asn Pro Leu 
            100                 105                 110         


Asn Ser Arg Ala Val Glu Asp Ile Ser Ser Ser Arg Xaa Asn Pro Tyr 
        115                 120                 125             


Ser Tyr Ala Met Ser Xaa Glu Glu Ala Arg Phe Leu Xaa Tyr His Met 
    130                 135                 140                 


Trp Pro Leu Xaa Phe Leu Ser Pro Ser Glu Leu Ala Arg Ala Gly Phe 
145                 150                 155                 160 


Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys Gly Gly 
                165                 170                 175     


Lys Leu Ser Asn Trp Glu Pro Lys Asp Asp Ala Met Ser Glu His Arg 
            180                 185                 190         


Arg His Phe Pro Asn Cys Pro Phe Leu Glu Asn Ser Leu Glu Xaa Leu 
        195                 200                 205             


Arg Phe Ser Ile Ser Asn Leu Ser Met Gln Xaa His Ala Ala Arg Met 
    210                 215                 220                 


Arg Xaa Phe Met Tyr Trp Pro Ser Ser Val Pro Val Gln Pro Glu Gln 
225                 230                 235                 240 


Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Arg Asn Asp Asp Val Lys 
                245                 250                 255     


Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser Gly Asp Asp 
            260                 265                 270         


Pro Trp Val Glu His Ala Lys Trp Phe Pro Arg Cys Glu Phe Leu Ile 
        275                 280                 285             


Arg Met Lys Gly Gln Glu Phe Val Asp Glu Ile Gln Gly Arg Tyr Pro 
    290                 295                 300                 


His Leu Leu Glu Gln Leu Leu Ser Xaa Ser Asp Xaa Xaa Gly Glu Glu 
305                 310                 315                 320 


Asn Ala Asp Pro Pro Ile Ile His Phe Gly Pro Gly Glu Ser Ser Ser 
                325                 330                 335     


Glu Asp Ala Val Met Met Asn Xaa Pro Val Val Lys Ser Ala Leu Glu 
            340                 345                 350         


Met Gly Phe Asn Arg Asp Leu Val Lys Gln Xaa Val Gln Ser Lys Ile 
        355                 360                 365             


Leu Xaa Xaa Gly Glu Asn Tyr Lys Xaa Val Asn Asp Ile Val Ser Ala 
    370                 375                 380                 


Leu Leu Asn Ala Glu Asp Glu Lys Arg Glu Glu Glu Lys Glu Lys Gln 
385                 390                 395                 400 


Ala Glu Glu Met Ala Ser Asp Asp Leu Ser Leu Ile Arg Lys Asn Arg 
                405                 410                 415     


Met Ala Leu Phe Gln Gln Leu Xaa Cys Val Leu Pro Ile Leu Asp Asn 
            420                 425                 430         


Leu Leu Lys Ala Asn Val Ile Asn Lys Gln Glu His Asp Ile Ile Lys 
        435                 440                 445             


Gln Lys Xaa Gln Ile Pro Leu Gln Ala Arg Glu Leu Ile Asp Xaa Ile 
    450                 455                 460                 


Leu Val Lys Gly Asn Ala Ala Ala Asn Ile Phe Lys Asn Cys Leu Lys 
465                 470                 475                 480 


Glu Ile Asp Ser Xaa Leu Tyr Lys Asn Leu Phe Val Asp Lys Asn Met 
                485                 490                 495     


Lys Tyr Ile Pro Xaa Glu Asp Val Ser Gly Leu Ser Leu Glu Glu Gln 
            500                 505                 510         


Leu Arg Arg Leu Gln Glu Glu Arg Xaa Cys Lys Val Cys Met Asp Lys 
        515                 520                 525             


Glu Val Ser Val Val Phe Ile Pro Cys Gly His Leu Val Val Cys Gln 
    530                 535                 540                 


Glu Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg Gly Ile Ile 
545                 550                 555                 560 


Lys Gly Xaa Val Arg Xaa Phe Leu Ser 
                565                 


<210> 4212
<211> 262
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<400> 4212
Tyr Asp Phe Ser Cys Glu Leu Tyr Arg Met Ser Xaa Tyr Ser Xaa Phe 
1               5                   10                  15      


Pro Ala Gly Val Pro Val Ser Glu Arg Ser Leu Ala Arg Ala Gly Phe 
            20                  25                  30          


Tyr Tyr Xaa Gly Val Asn Asp Lys Val Lys Cys Phe Cys Cys Gly Leu 
        35                  40                  45              


Met Leu Asp Asn Trp Lys Leu Gly Asp Ser Pro Ile Gln Lys His Lys 
    50                  55                  60                  


Gln Leu Tyr Pro Ser Cys Ser Phe Ile Gln Asn Leu Val Ser Ala Ser 
65                  70                  75                  80  


Leu Gly Ser Xaa Ser Lys Asn Xaa Ser Pro Met Arg Asn Ser Phe Ala 
                85                  90                  95      


His Ser Leu Ser Pro Xaa Leu Glu His Ser Ser Leu Phe Ser Gly Ser 
            100                 105                 110         


Tyr Ser Ser Leu Ser Pro Asn Pro Leu Asn Ser Arg Ala Val Glu Asp 
        115                 120                 125             


Ile Ser Ser Ser Arg Xaa Asn Pro Tyr Ser Tyr Ala Met Ser Xaa Glu 
    130                 135                 140                 


Glu Ala Arg Phe Leu Xaa Tyr His Met Trp Pro Leu Xaa Phe Leu Ser 
145                 150                 155                 160 


Pro Ser Glu Leu Ala Arg Ala Gly Phe Tyr Tyr Ile Gly Pro Gly Asp 
                165                 170                 175     


Arg Val Ala Cys Phe Ala Cys Gly Gly Lys Leu Ser Asn Trp Glu Pro 
            180                 185                 190         


Lys Asp Asp Ala Met Ser Glu His Arg Arg His Phe Pro Asn Cys Pro 
        195                 200                 205             


Phe Leu Glu Asn Ser Leu Glu Xaa Leu Arg Phe Ser Ile Ser Asn Leu 
    210                 215                 220                 


Ser Met Gln Xaa His Ala Ala Arg Met Arg Xaa Phe Met Tyr Trp Pro 
225                 230                 235                 240 


Ser Ser Val Pro Val Gln Pro Glu Gln Leu Ala Ser Ala Gly Phe Tyr 
                245                 250                 255     


Tyr Val Gly Val Ser Ser 
            260         


<210> 4213
<211> 604
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<400> 4213
Met Asn Ile Val Glu Asn Ser Ile Phe Leu Ser Asn Leu Met Lys Ser 
1               5                   10                  15      


Ala Asn Xaa Phe Glu Leu Lys Tyr Asp Leu Ser Cys Glu Leu Tyr Arg 
            20                  25                  30          


Met Ser Xaa Tyr Ser Xaa Phe Pro Ala Gly Val Pro Val Ser Glu Arg 
        35                  40                  45              


Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Xaa Gly Val Asn Asp Lys Val 
    50                  55                  60                  


Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Arg Gly Asp 
65                  70                  75                  80  


Ser Pro Xaa Glu Lys His Lys Lys Leu Tyr Pro Ser Cys Arg Phe Val 
                85                  90                  95      


Gln Ser Leu Asn Ser Val Asn Asn Leu Glu Ala Xaa Ser Gln Pro Xaa 
            100                 105                 110         


Phe Pro Ser Ser Val Xaa Asn Ser Xaa His Ser Leu Leu Pro Gly Xaa 
        115                 120                 125             


Glu Asn Ser Gly Tyr Phe Arg Gly Ser Tyr Ser Asn Ser Pro Ser Asn 
    130                 135                 140                 


Pro Val Asn Ser Arg Ala Asn Gln Asp Phe Ser Ala Leu Met Arg Ser 
145                 150                 155                 160 


Ser Tyr His Cys Ala Met Asn Asn Glu Asn Ala Arg Leu Leu Xaa Phe 
                165                 170                 175     


Gln Xaa Trp Pro Leu Xaa Phe Leu Ser Pro Xaa Asp Leu Ala Lys Ala 
            180                 185                 190         


Gly Phe Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys 
        195                 200                 205             


Gly Gly Lys Leu Ser Asn Trp Glu Pro Lys Asp Asn Ala Met Ser Glu 
    210                 215                 220                 


His Leu Arg His Phe Pro Lys Cys Pro Phe Ile Glu Asn Gln Leu Gln 
225                 230                 235                 240 


Asp Xaa Ser Arg Tyr Xaa Val Ser Asn Leu Ser Met Gln Xaa His Ala 
                245                 250                 255     


Ala Arg Phe Lys Xaa Phe Phe Asn Trp Pro Ser Ser Val Leu Val Asn 
            260                 265                 270         


Pro Glu Gln Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Asn Ser Asp 
        275                 280                 285             


Asp Val Lys Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser 
    290                 295                 300                 


Gly Asp Asp Pro Trp Val Gln His Ala Lys Trp Phe Pro Arg Cys Glu 
305                 310                 315                 320 


Tyr Leu Ile Arg Ile Lys Gly Gln Glu Phe Ile Arg Gln Val Gln Ala 
                325                 330                 335     


Ser Tyr Pro His Leu Leu Glu Gln Leu Leu Ser Xaa Ser Asp Ser Pro 
            340                 345                 350         


Gly Asp Glu Asn Ala Glu Ser Ser Ile Ile His Phe Glu Pro Gly Glu 
        355                 360                 365             


Asp His Ser Glu Asp Ala Ile Met Met Asn Xaa Pro Val Ile Asn Ala 
    370                 375                 380                 


Ala Val Glu Met Gly Phe Ser Arg Ser Leu Val Lys Gln Xaa Val Gln 
385                 390                 395                 400 


Arg Lys Ile Leu Ala Xaa Gly Glu Asn Tyr Arg Leu Val Asn Asp Leu 
                405                 410                 415     


Val Leu Asp Leu Leu Asn Ala Glu Asp Glu Ile Arg Glu Glu Glu Arg 
            420                 425                 430         


Glu Arg Ala Xaa Glu Glu Lys Glu Ser Asn Asp Leu Leu Leu Ile Arg 
        435                 440                 445             


Lys Asn Arg Met Ala Leu Phe Gln His Leu Xaa Cys Val Ile Pro Ile 
    450                 455                 460                 


Leu Asp Ser Leu Leu Xaa Ala Gly Ile Ile Asn Glu Gln Glu His Asp 
465                 470                 475                 480 


Val Ile Lys Gln Lys Xaa Gln Xaa Ser Leu Gln Ala Arg Glu Leu Ile 
                485                 490                 495     


Asp Xaa Ile Leu Val Lys Gly Asn Ile Ala Ala Xaa Val Phe Arg Asn 
            500                 505                 510         


Ser Leu Gln Glu Ala Glu Ala Val Leu Tyr Glu His Leu Phe Val Gln 
        515                 520                 525             


Gln Asp Ile Lys Tyr Ile Pro Xaa Glu Asp Val Ser Asp Leu Pro Val 
    530                 535                 540                 


Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Arg Xaa Cys Lys Val Cys 
545                 550                 555                 560 


Met Asp Lys Glu Val Ser Ile Val Phe Ile Pro Cys Gly His Leu Val 
                565                 570                 575     


Val Cys Lys Asp Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg 
            580                 585                 590         


Ser Xaa Ile Lys Gly Xaa Val Arg Xaa Phe Leu Ser 
        595                 600                 


<210> 4214
<211> 183
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<400> 4214
Gln Leu Gln Asp Xaa Ser Arg Tyr Xaa Val Ser Asn Leu Ser Met Gln 
1               5                   10                  15      


Xaa His Ala Ala Arg Phe Lys Xaa Phe Phe Asn Trp Pro Ser Ser Val 
            20                  25                  30          


Leu Val Asn Pro Glu Gln Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly 
        35                  40                  45              


Asn Ser Asp Asp Val Lys Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys 
    50                  55                  60                  


Trp Glu Ser Gly Asp Asp Pro Trp Val Gln His Ala Lys Trp Phe Pro 
65                  70                  75                  80  


Arg Trp Ser Leu Ala Leu Leu Pro Arg Leu Glu Cys Asp Gly Val Met 
                85                  90                  95      


Ser Ala His Cys Asn Leu Arg Leu Leu Gly Ser Gly Asn Ser His Ala 
            100                 105                 110         


Ser Ser Leu Ala Ser Ser Trp Asp Tyr Arg Cys Glu Tyr Leu Ile Arg 
        115                 120                 125             


Ile Lys Gly Gln Glu Phe Ile Arg Gln Val Gln Ala Ser Tyr Pro His 
    130                 135                 140                 


Leu Leu Glu Gln Leu Leu Ser Xaa Ser Asp Ser Pro Gly Asp Glu Asn 
145                 150                 155                 160 


Ala Glu Ser Ser Ile Ile His Phe Glu Pro Gly Glu Asp His Ser Glu 
                165                 170                 175     


Asp Ala Ile Met Met Asn Xaa 
            180             


<210> 4215
<211> 142
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 4215
Met Gly Ala Pro Xaa Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Xaa Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Xaa Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Xaa 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His 
65                  70                  75                  80  


Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu 
                85                  90                  95      


Xaa Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys 
            100                 105                 110         


Ile Ala Lys Glu Xaa Asn Asn Lys Lys Lys Glu Phe Glu Glu Xaa Ala 
        115                 120                 125             


Glu Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp 
    130                 135                 140         


<210> 4216
<211> 120
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<400> 4216
Met Gly Ala Pro Xaa Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Xaa Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Xaa Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Xaa 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His 
65                  70                  75                  80  


Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu 
                85                  90                  95      


Xaa Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys 
            100                 105                 110         


Ile Glu Arg Ala Leu Leu Ala Glu 
        115                 120 


<210> 4217
<211> 165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 4217
Met Gly Ala Pro Xaa Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Xaa Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Xaa Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Xaa 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Gly Pro Gly Xaa Val Ala 
65                  70                  75                  80  


Tyr Ala Cys Asn Xaa Ser Xaa Leu Gly Gly Arg Gly Gly Arg Ile Xaa 
                85                  90                  95      


Arg Glu Glu His Lys Lys His Ser Ser Gly Cys Ala Phe Leu Ser Val 
            100                 105                 110         


Lys Lys Gln Phe Glu Glu Leu Xaa Leu Gly Glu Phe Leu Lys Leu Asp 
        115                 120                 125             


Arg Glu Arg Ala Lys Asn Lys Ile Ala Lys Glu Xaa Asn Asn Lys Lys 
    130                 135                 140                 


Lys Glu Phe Glu Glu Xaa Ala Glu Lys Val Arg Arg Ala Ile Glu Gln 
145                 150                 155                 160 


Leu Ala Ala Met Asp 
                165 


<210> 4218
<211> 74
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<400> 4218
Met Gly Ala Pro Xaa Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Xaa Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Xaa Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Xaa 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Met 
65                  70                  


<210> 4219
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 4219
Met Gly Ala Pro Xaa Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Xaa Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Xaa Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Xaa 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Met Gln Arg Lys Pro Xaa Ile 
65                  70                  75                  80  


Arg Arg Lys Asn Leu Arg Lys Leu Arg Arg Lys Cys Ala Val Pro Ser 
                85                  90                  95      


Ser Ser Trp Leu Pro Trp Ile Glu Ala Ser Gly Arg Ser Cys Leu Val 
            100                 105                 110         


Pro Glu Trp Leu His His Phe Gln Gly Leu Phe Pro Gly Ala Xaa Ser 
        115                 120                 125             


Leu Pro Val Gly Pro Leu Ala Met Ser 
    130                 135         


<210> 4220
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<400> 4220
Met Gly Ala Pro Xaa Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Xaa Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Xaa Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Xaa 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Met Arg Glu Leu Cys 
65                  70                  75              


<210> 4221
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 4221
Xaa Asn Trp Pro Phe Leu Glu Gly Cys Ala Cys Xaa Pro Glu Arg Met 
1               5                   10                  15      


Ala Glu Ala Gly Phe Ile His Cys Pro Xaa Glu Asn Glu Pro Asp Leu 
            20                  25                  30          


Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu Glu Gly Trp Glu Pro Asp 
        35                  40                  45              


Asp Asp Pro Ile Gly Pro Gly Xaa Val Ala Tyr Ala Cys Asn Xaa Ser 
    50                  55                  60                  


Xaa Leu Gly Gly Arg Gly Gly Arg Ile Xaa Arg Glu Glu His Lys Lys 
65                  70                  75                  80  


His Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu 
                85                  90                  95      


Leu Xaa Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn 
            100                 105                 110         


Lys Ile Glu Arg Ala Leu Leu Ala Glu 
        115                 120     


<210> 4222
<211> 83
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<400> 4222
Xaa Asn Trp Pro Phe Leu Glu Gly Cys Ala Cys Xaa Pro Glu Arg Met 
1               5                   10                  15      


Ala Glu Ala Gly Phe Ile His Cys Pro Xaa Glu Asn Glu Pro Asp Leu 
            20                  25                  30          


Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu Glu Gly Trp Glu Pro Asp 
        35                  40                  45              


Asp Asp Pro Ile Gly Pro Gly Xaa Val Ala Tyr Ala Cys Asn Xaa Ser 
    50                  55                  60                  


Xaa Leu Gly Gly Arg Gly Gly Arg Ile Xaa Arg Ser Gly Asp Arg Asp 
65                  70                  75                  80  


His Leu Gly 
            


<210> 4223
<211> 52
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<400> 4223
Xaa Asn Trp Pro Phe Leu Glu Gly Cys Ala Cys Xaa Pro Glu Arg Met 
1               5                   10                  15      


Ala Glu Ala Gly Phe Ile His Cys Pro Xaa Glu Asn Glu Pro Asp Leu 
            20                  25                  30          


Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu Glu Gly Trp Glu Pro Asp 
        35                  40                  45              


Asp Asp Pro Met 
    50          


<210> 4224
<211> 4857
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1123)..(1123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1281)..(1281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1339)..(1339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1355)..(1355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1443)..(1444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1475)..(1475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1486)..(1486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1494)..(1494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1548)..(1548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1558)..(1558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1569)..(1569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1577)..(1577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1591)..(1591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1601)..(1601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1658)..(1659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1697)..(1697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1700)..(1701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1706)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1710)..(1710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1792)..(1792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1802)..(1802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1808)..(1808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1821)..(1821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1835)..(1835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1839)..(1839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1859)..(1859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1867)..(1867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1882)..(1882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1937)..(1937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2008)..(2008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2017)..(2017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2020)..(2020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2025)..(2025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2033)..(2033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2053)..(2053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2071)..(2071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2078)..(2078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2159)..(2159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2184)..(2184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2210)..(2210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2282)..(2282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2295)..(2295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2305)..(2305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2308)..(2309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2322)..(2322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2345)..(2345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2365)..(2365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2368)..(2368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2390)..(2390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2409)..(2409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2433)..(2433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2441)..(2441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2459)..(2459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2465)..(2465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2469)..(2469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2519)..(2519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2530)..(2530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2551)..(2551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2558)..(2558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2588)..(2588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2599)..(2599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2601)..(2601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2604)..(2604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2610)..(2610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2612)..(2612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2626)..(2626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2666)..(2666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2674)..(2674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2702)..(2702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2706)..(2706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2714)..(2714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2718)..(2718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2727)..(2727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2730)..(2730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2744)..(2744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2748)..(2748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2769)..(2769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2774)..(2774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2784)..(2784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2786)..(2786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2794)..(2794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2803)..(2803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2821)..(2821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2828)..(2828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2843)..(2843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2855)..(2855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2864)..(2864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2872)..(2872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2914)..(2914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2947)..(2948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2950)..(2951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2971)..(2971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3018)..(3018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3038)..(3038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3041)..(3042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3049)..(3049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3059)..(3059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3074)..(3074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3091)..(3091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3113)..(3113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3115)..(3115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3121)..(3121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3128)..(3128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3144)..(3144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3147)..(3147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3168)..(3168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3170)..(3170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3175)..(3175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3186)..(3186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3211)..(3211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3234)..(3234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3255)..(3255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3259)..(3259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3263)..(3263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3290)..(3290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3302)..(3302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3306)..(3307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3311)..(3311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3326)..(3326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3339)..(3339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3355)..(3355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3361)..(3361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3390)..(3390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3412)..(3412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3431)..(3431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3440)..(3441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3446)..(3446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3481)..(3481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3567)..(3567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3580)..(3580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3593)..(3593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3606)..(3606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3612)..(3612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3679)..(3679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3691)..(3691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3713)..(3713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3725)..(3725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3736)..(3736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3748)..(3749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3752)..(3753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3757)..(3757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3763)..(3763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3791)..(3791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3800)..(3800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3823)..(3823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3840)..(3840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3857)..(3857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3864)..(3865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3876)..(3876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3880)..(3880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3931)..(3931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3942)..(3942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3950)..(3950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3961)..(3961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3982)..(3982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3988)..(3988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4005)..(4005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4014)..(4014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4021)..(4021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4047)..(4047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4064)..(4064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4104)..(4104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4106)..(4107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4121)..(4121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4135)..(4135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4149)..(4149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4192)..(4192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4211)..(4211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4223)..(4224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4227)..(4228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4269)..(4269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4280)..(4280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4282)..(4282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4293)..(4293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4297)..(4297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4300)..(4300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4311)..(4311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4321)..(4321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4348)..(4348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4417)..(4417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4431)..(4431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4435)..(4435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4442)..(4442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4446)..(4446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4448)..(4448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4460)..(4460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4475)..(4475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4484)..(4484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4492)..(4493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4539)..(4539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4584)..(4584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4587)..(4587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4614)..(4614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4619)..(4619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4647)..(4648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4672)..(4672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4685)..(4685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4717)..(4717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4721)..(4721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4735)..(4735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4789)..(4789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4801)..(4801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4821)..(4821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4831)..(4832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4837)..(4837)
<223> Selenocysteine

<400> 4224
Met Val Xaa Gly Gly Gly Ala Ala Pro Pro Gly Xaa Val Xaa Glu Pro 
1               5                   10                  15      


Leu Pro Ser Val Ile Val Leu Ser Ala Gly Arg Lys Met Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ser Gly Pro Gly Cys Ser Ser Ala Ala Gly Ala Gly 
        35                  40                  45              


Ala Ala Gly Val Ser Glu Trp Leu Val Leu Arg Asp Gly Cys Met His 
    50                  55                  60                  


Cys Asp Ala Asp Gly Leu His Ser Leu Ser Tyr His Pro Ala Leu Asn 
65                  70                  75                  80  


Ala Ile Leu Ala Val Xaa Ser Arg Gly Xaa Ile Lys Val Ile Asp Gly 
                85                  90                  95      


Xaa Ser Gly Ala Xaa Leu Gln Ala Ser Ala Leu Ser Ala Lys Pro Gly 
            100                 105                 110         


Gly Gln Val Lys Cys Gln Tyr Ile Ser Ala Val Asp Lys Val Ile Phe 
        115                 120                 125             


Val Asp Asp Tyr Ala Val Gly Cys Arg Lys Asp Leu Asn Gly Ile Leu 
    130                 135                 140                 


Leu Leu Asp Xaa Ala Leu Gln Xaa Pro Val Ser Lys Gln Asp Asp Val 
145                 150                 155                 160 


Val Gln Leu Glu Leu Pro Val Xaa Glu Ala Gln Gln Leu Leu Ser Ala 
                165                 170                 175     


Cys Leu Glu Lys Val Asp Ile Ser Ser Xaa Glu Gly Tyr Asp Leu Phe 
            180                 185                 190         


Ile Xaa Gln Leu Lys Asp Gly Leu Lys Asn Xaa Ser His Glu Xaa Ala 
        195                 200                 205             


Ala Asn His Lys Val Ala Lys Trp Ala Xaa Val Xaa Phe His Leu Pro 
    210                 215                 220                 


His His Val Leu Lys Ser Ile Ala Ser Ala Ile Val Asn Glu Leu Lys 
225                 230                 235                 240 


Lys Ile Asn Gln Asn Val Ala Ala Leu Pro Val Ala Ser Ser Val Met 
                245                 250                 255     


Asp Arg Leu Ser Tyr Leu Leu Pro Ser Ala Arg Pro Glu Leu Gly Val 
            260                 265                 270         


Gly Pro Gly Arg Ser Val Asp Arg Ser Leu Met Tyr Ser Glu Ala Asn 
        275                 280                 285             


Arg Arg Glu Xaa Phe Xaa Ser Trp Pro His Val Gly Tyr Arg Trp Ala 
    290                 295                 300                 


Gln Pro Asp Pro Met Ala Gln Ala Gly Phe Tyr His Gln Pro Ala Ser 
305                 310                 315                 320 


Ser Gly Asp Asp Arg Ala Met Cys Phe Xaa Cys Ser Val Cys Leu Val 
                325                 330                 335     


Cys Trp Glu Pro Xaa Asp Glu Pro Trp Ser Glu His Glu Arg His Ser 
            340                 345                 350         


Pro Asn Cys Pro Phe Val Lys Gly Glu His Xaa Gln Asn Val Pro Leu 
        355                 360                 365             


Ser Val Xaa Leu Ala Xaa Ser Pro Ala Gln Phe Pro Cys Xaa Asp Gly 
    370                 375                 380                 


Xaa Asp Arg Ile Ser Cys Phe Gly Ser Gly Ser Cys Pro His Phe Leu 
385                 390                 395                 400 


Ala Ala Ala Xaa Lys Arg Gly Lys Ile Cys Ile Trp Asp Val Ser Lys 
                405                 410                 415     


Leu Met Lys Val His Leu Lys Phe Glu Ile Asn Ala Tyr Asp Pro Ala 
            420                 425                 430         


Ile Val Gln Gln Leu Ile Leu Ser Gly Asp Pro Ser Ser Gly Val Asp 
        435                 440                 445             


Ser Arg Arg Pro Xaa Leu Ala Trp Leu Glu Asp Ser Ser Ser Cys Ser 
    450                 455                 460                 


Asp Ile Pro Lys Leu Glu Gly Asp Ser Asp Asp Leu Leu Glu Asp Ser 
465                 470                 475                 480 


Asp Ser Glu Glu His Ser Arg Ser Asp Ser Val Xaa Gly His Xaa Ser 
                485                 490                 495     


Gln Lys Glu Ala Met Glu Val Ser Leu Asp Ile Xaa Ala Leu Ser Ile 
            500                 505                 510         


Leu Gln Gln Pro Glu Lys Leu Gln Trp Glu Ile Val Ala Asn Val Leu 
        515                 520                 525             


Glu Asp Xaa Val Lys Asp Leu Glu Glu Leu Gly Ala Asn Pro Cys Leu 
    530                 535                 540                 


Xaa Asn Ser Lys Ser Glu Lys Xaa Lys Glu Lys His Gln Glu Gln His 
545                 550                 555                 560 


Asn Ile Pro Phe Pro Cys Leu Leu Ala Gly Gly Leu Leu Xaa Tyr Lys 
                565                 570                 575     


Ser Pro Ala Xaa Ser Pro Ile Ser Ser Asn Ser His Arg Ser Leu Asp 
            580                 585                 590         


Gly Leu Ser Arg Xaa Gln Gly Glu Ser Ile Ser Glu Gln Gly Ser Xaa 
        595                 600                 605             


Asp Asn Glu Ser Cys Xaa Asn Ser Glu Leu Asn Ser Pro Leu Val Arg 
    610                 615                 620                 


Arg Xaa Leu Pro Val Leu Leu Leu Tyr Ser Ile Lys Glu Ser Asp Glu 
625                 630                 635                 640 


Lys Ala Gly Lys Ile Phe Ser Gln Met Asn Asn Ile Met Ser Lys Ser 
                645                 650                 655     


Leu His Asp Asp Gly Phe Xaa Val Pro Gln Ile Ile Glu Met Glu Leu 
            660                 665                 670         


Asp Ser Gln Glu Gln Leu Leu Leu Gln Asp Pro Pro Val Xaa Tyr Ile 
        675                 680                 685             


Gln Gln Phe Ala Asp Ala Ala Ala Asn Leu Xaa Ser Pro Asp Ser Glu 
    690                 695                 700                 


Lys Trp Asn Ser Val Phe Pro Lys Pro Gly Xaa Leu Val Gln Cys Leu 
705                 710                 715                 720 


Arg Leu Pro Lys Phe Ala Glu Glu Glu Asn Leu Cys Ile Asp Ser Ile 
                725                 730                 735     


Xaa Pro Cys Ala Asp Gly Ile His Leu Leu Val Gly Leu Arg Xaa Cys 
            740                 745                 750         


Pro Val Glu Ser Leu Ser Ala Ile Asn Gln Val Glu Ala Leu Asn Asn 
        755                 760                 765             


Leu Asn Lys Leu Asn Ser Ala Leu Cys Asn Arg Arg Lys Gly Glu Leu 
    770                 775                 780                 


Glu Ser Asn Leu Ala Val Val Asn Gly Ala Asn Ile Ser Val Ile Gln 
785                 790                 795                 800 


His Glu Ser Pro Ala Asp Val Gln Xaa Pro Leu Ile Ile Gln Pro Glu 
                805                 810                 815     


Gln Arg Asn Val Ser Gly Gly Tyr Leu Val Leu Tyr Lys Met Asn Tyr 
            820                 825                 830         


Ala Xaa Arg Ile Val Xaa Leu Glu Glu Glu Pro Ile Lys Ile Gln His 
        835                 840                 845             


Ile Lys Asp Pro Gln Asp Xaa Ile Xaa Ser Leu Ile Leu Leu Pro Pro 
    850                 855                 860                 


Asp Ile Leu Asp Asn Arg Glu Asp Asp Cys Glu Glu Pro Ile Glu Asp 
865                 870                 875                 880 


Met Gln Leu Xaa Ser Lys Asn Gly Phe Glu Arg Glu Lys Xaa Ser Asp 
                885                 890                 895     


Ile Ser Xaa Leu Gly His Leu Val Ile Xaa Xaa Gln Gly Gly Tyr Val 
            900                 905                 910         


Lys Ile Leu Asp Leu Ser Asn Phe Glu Ile Leu Ala Lys Val Glu Pro 
        915                 920                 925             


Pro Lys Lys Glu Gly Xaa Glu Glu Gln Asp Xaa Phe Val Ser Val Ile 
    930                 935                 940                 


Tyr Cys Ser Gly Xaa Asp Arg Leu Cys Ala Cys Xaa Lys Gly Gly Glu 
945                 950                 955                 960 


Leu His Phe Leu Gln Ile Gly Gly Xaa Cys Asp Asp Ile Asp Glu Ala 
                965                 970                 975     


Asp Ile Leu Val Asp Gly Ser Leu Ser Lys Gly Ile Glu Pro Ser Ser 
            980                 985                 990         


Glu Gly Ser Lys Pro Leu Ser Asn  Pro Ser Ser Pro Gly  Ile Ser Gly 
        995                 1000                 1005             


Val Asp  Leu Leu Val Asp Gln  Pro Phe Xaa Leu Glu  Ile Leu Xaa 
    1010                 1015                 1020             


Ser Leu  Val Glu Leu Xaa Arg  Phe Glu Xaa Leu Xaa  Pro Arg Phe 
    1025                 1030                 1035             


Ser Ala  Xaa Val Pro Pro Cys  Trp Val Glu Val Gln  Gln Glu Gln 
    1040                 1045                 1050             


Gln Gln  Arg Arg His Pro Gln  His Leu His Gln Gln  His His Gly 
    1055                 1060                 1065             


Asp Ala  Ala Gln His Xaa Arg  Xaa Trp Lys Leu Gln  Xaa Asp Ser 
    1070                 1075                 1080             


Asn Ser  Trp Asp Glu His Val  Phe Glu Leu Val Leu  Pro Lys Ala 
    1085                 1090                 1095             


Cys Met  Val Gly His Val Asp  Phe Lys Phe Val Leu  Asn Ser Asn 
    1100                 1105                 1110             


Ile Xaa  Asn Ile Pro Gln Ile  Gln Val Xaa Leu Leu  Lys Asn Lys 
    1115                 1120                 1125             


Ala Pro  Gly Leu Gly Lys Val  Asn Ala Leu Asn Ile  Glu Val Glu 
    1130                 1135                 1140             


Gln Asn  Gly Lys Pro Ser Leu  Val Asp Leu Asn Glu  Glu Met Gln 
    1145                 1150                 1155             


His Met  Asp Val Glu Glu Ser  Gln Cys Leu Arg Leu  Cys Pro Phe 
    1160                 1165                 1170             


Leu Glu  Asp His Lys Glu Asp  Ile Leu Cys Gly Pro  Val Trp Leu 
    1175                 1180                 1185             


Ala Ser  Gly Leu Asp Leu Ser  Gly His Ala Gly Met  Leu Xaa Leu 
    1190                 1195                 1200             


Xaa Ser  Pro Lys Leu Val Lys  Gly Met Ala Gly Gly  Lys Tyr Arg 
    1205                 1210                 1215             


Ser Phe  Leu Ile His Val Lys  Ala Val Asn Glu Arg  Gly Xaa Glu 
    1220                 1225                 1230             


Glu Ile  Cys Asn Gly Gly Met  Arg Pro Val Val Arg  Leu Pro Ser 
    1235                 1240                 1245             


Leu Lys  His Gln Ser Asn Lys  Gly Tyr Ser Leu Ala  Ser Leu Leu 
    1250                 1255                 1260             


Ala Lys  Val Ala Ala Gly Lys  Glu Lys Ser Ser Asn  Val Lys Asn 
    1265                 1270                 1275             


Glu Asn  Xaa Ser Gly Xaa Arg  Lys Ser Glu Asn Leu  Arg Gly Cys 
    1280                 1285                 1290             


Asp Leu  Leu Gln Glu Val Ser  Val Xaa Ile Arg Arg  Phe Lys Lys 
    1295                 1300                 1305             


Xaa Ser  Ile Ser Lys Glu Arg  Val Gln Arg Cys Ala  Met Leu Gln 
    1310                 1315                 1320             


Phe Ser  Glu Phe His Glu Lys  Leu Leu Asn Xaa Leu  Cys Arg Lys 
    1325                 1330                 1335             


Xaa Asp  Asp Gly Gln Ile Xaa  Glu His Ala Gln Ser  Leu Val Leu 
    1340                 1345                 1350             


Asp Xaa  Leu Cys Trp Leu Ala  Gly Val His Ser Asn  Gly Pro Gly 
    1355                 1360                 1365             


Ser Ser  Lys Glu Gly Asn Glu  Asn Leu Leu Ser Lys  Xaa Arg Lys 
    1370                 1375                 1380             


Phe Leu  Ser Asp Ile Val Arg  Val Cys Phe Phe Glu  Ala Gly Arg 
    1385                 1390                 1395             


Ser Ile  Ala His Lys Cys Ala  Arg Phe Leu Ala Leu  Cys Ile Ser 
    1400                 1405                 1410             


Asn Gly  Lys Cys Asp Pro Cys  Gln Pro Ala Phe Gly  Pro Val Leu 
    1415                 1420                 1425             


Leu Lys  Ala Leu Leu Asp Asn  Met Ser Phe Leu Pro  Ala Ala Xaa 
    1430                 1435                 1440             


Xaa Gly  Gly Ser Val Tyr Trp  Tyr Phe Val Leu Leu  Asn Tyr Val 
    1445                 1450                 1455             


Lys Asp  Glu Asp Leu Ala Gly  Cys Ser Xaa Ala Cys  Ala Ser Leu 
    1460                 1465                 1470             


Leu Xaa  Ala Val Ser Arg Gln  Leu Gln Asp Arg Leu  Xaa Pro Met 
    1475                 1480                 1485             


Glu Ala  Leu Leu Gln Xaa Arg  Tyr Gly Leu Tyr Ser  Ser Pro Phe 
    1490                 1495                 1500             


Asp Pro  Val Leu Phe Asp Leu  Glu Met Ser Gly Ser  Ser Cys Lys 
    1505                 1510                 1515             


Asn Val  Tyr Asn Ser Ser Ile  Gly Val Gln Ser Asp  Glu Ile Asp 
    1520                 1525                 1530             


Leu Ser  Asp Val Leu Ser Gly  Asn Gly Lys Val Ser  Ser Cys Xaa 
    1535                 1540                 1545             


Ala Ala  Glu Gly Ser Phe Xaa  Ser Leu Xaa Gly Leu  Leu Glu Val 
    1550                 1555                 1560             


Glu Pro  Leu His Phe Xaa Cys  Val Ser Xaa Ser Asp  Gly Xaa Arg 
    1565                 1570                 1575             


Ile Glu  Arg Asp Asp Ala Met  Ser Ser Phe Gly Val  Xaa Pro Ala 
    1580                 1585                 1590             


Val Gly  Gly Leu Ser Ser Gly  Xaa Val Gly Glu Ala  Ser Xaa Ala 
    1595                 1600                 1605             


Leu Ser  Ser Ala Ala Gln Val  Ala Leu Gln Ser Leu  Ser His Ala 
    1610                 1615                 1620             


Met Ala  Ser Ala Glu Gln Gln  Leu Gln Val Leu Gln  Glu Lys Gln 
    1625                 1630                 1635             


Gln Gln  Leu Leu Lys Leu Gln  Gln Gln Lys Ala Lys  Leu Glu Ala 
    1640                 1645                 1650             


Lys Leu  His Gln Xaa Xaa Ala  Ala Ala Ala Ala Ala  Ala Ser Ala 
    1655                 1660                 1665             


Val Gly  Pro Val His Asn Ser  Val Pro Ser Asn Pro  Val Ala Ala 
    1670                 1675                 1680             


Pro Gly  Phe Phe Ile His Pro  Ser Asp Val Ile Pro  Pro Xaa Pro 
    1685                 1690                 1695             


Lys Xaa  Xaa Pro Leu Phe Met  Xaa Pro Pro Leu Xaa  Pro Pro Asn 
    1700                 1705                 1710             


Glu Ala  Val Ser Val Val Ile  Asn Ala Glu Leu Ala  Gln Leu Phe 
    1715                 1720                 1725             


Pro Gly  Ser Val Ile Asp Pro  Pro Ala Val Asn Leu  Ala Ala His 
    1730                 1735                 1740             


Asn Lys  Asn Ser Asn Lys Ser  Arg Met Asn Pro Leu  Gly Ser Gly 
    1745                 1750                 1755             


Leu Ala  Leu Ala Ile Ser His  Ala Ser His Phe Leu  Gln Pro Pro 
    1760                 1765                 1770             


Pro His  Gln Ser Ile Ile Ile  Glu Arg Met His Ser  Gly Ala Arg 
    1775                 1780                 1785             


Arg Phe  Val Xaa Leu Asp Phe  Gly Arg Pro Ile Leu  Leu Xaa Asp 
    1790                 1795                 1800             


Val Leu  Ile Pro Xaa Cys Gly  Asp Leu Ala Ser Leu  Ser Ile Asp 
    1805                 1810                 1815             


Ile Trp  Xaa Leu Gly Glu Glu  Val Asp Gly Arg Arg  Leu Val Val 
    1820                 1825                 1830             


Ala Xaa  Asp Ile Ser Xaa His  Ser Leu Ile Leu His  Asp Leu Ile 
    1835                 1840                 1845             


Pro Pro  Pro Val Cys Arg Phe  Met Lys Ile Xaa Val  Ile Gly Arg 
    1850                 1855                 1860             


Tyr Gly  Ser Xaa Asn Ala Arg  Ala Lys Ile Pro Leu  Gly Phe Tyr 
    1865                 1870                 1875             


Tyr Gly  His Xaa Tyr Ile Leu  Pro Trp Glu Ser Glu  Leu Lys Leu 
    1880                 1885                 1890             


Met His  Asp Pro Leu Lys Gly  Glu Gly Glu Ser Ala  Asn Gln Pro 
    1895                 1900                 1905             


Glu Ile  Asp Gln His Leu Ala  Met Met Val Ala Leu  Gln Glu Asp 
    1910                 1915                 1920             


Ile Gln  Cys Arg Tyr Asn Leu  Ala Cys His Arg Leu  Glu Xaa Leu 
    1925                 1930                 1935             


Leu Gln  Ser Ile Asp Leu Pro  Pro Leu Asn Ser Ala  Asn Asn Ala 
    1940                 1945                 1950             


Gln Tyr  Phe Leu Arg Lys Pro  Asp Lys Ala Val Glu  Glu Asp Ser 
    1955                 1960                 1965             


Arg Val  Phe Ser Ala Tyr Gln  Asp Cys Ile Gln Leu  Gln Leu Gln 
    1970                 1975                 1980             


Leu Asn  Leu Ala His Asn Ala  Val Gln Arg Leu Lys  Val Ala Leu 
    1985                 1990                 1995             


Gly Ala  Ser Arg Lys Met Leu  Ser Glu Xaa Ser Asn  Pro Glu Asp 
    2000                 2005                 2010             


Leu Ile  Gln Xaa Ser Ser Xaa  Glu Gln Leu Arg Xaa  Ile Ile Arg 
    2015                 2020                 2025             


Tyr Leu  Leu Asp Xaa Leu Leu  Ser Leu Leu His Ala  Ser Asn Gly 
    2030                 2035                 2040             


His Ser  Val Pro Ala Val Leu  Gln Ser Xaa Phe His  Ala Gln Ala 
    2045                 2050                 2055             


Cys Glu  Glu Leu Phe Lys His  Leu Cys Ile Ser Gly  Xaa Pro Lys 
    2060                 2065                 2070             


Ile Arg  Leu His Xaa Gly Leu  Leu Leu Val Gln Leu  Cys Gly Gly 
    2075                 2080                 2085             


Glu Arg  Trp Trp Gly Gln Phe  Leu Ser Asn Val Leu  Gln Glu Leu 
    2090                 2095                 2100             


Tyr Asn  Ser Glu Gln Leu Leu  Ile Phe Pro Gln Asp  Arg Val Phe 
    2105                 2110                 2115             


Met Leu  Leu Ser Cys Ile Gly  Gln Arg Ser Leu Ser  Asn Ser Gly 
    2120                 2125                 2130             


Val Leu  Glu Ser Leu Leu Asn  Leu Leu Asp Asn Leu  Leu Ser Pro 
    2135                 2140                 2145             


Leu Gln  Pro Gln Leu Pro Met  His Arg Arg Xaa Glu  Gly Val Leu 
    2150                 2155                 2160             


Asp Ile  Pro Met Ile Ser Trp  Val Val Met Leu Val  Ser Arg Leu 
    2165                 2170                 2175             


Leu Asp  Tyr Val Ala Xaa Val  Glu Asp Glu Ala Ala  Ala Ala Lys 
    2180                 2185                 2190             


Lys Pro  Leu Asn Gly Asn Gln  Trp Ser Phe Ile Asn  Asn Asn Leu 
    2195                 2200                 2205             


His Xaa  Gln Ser Leu Asn Arg  Ser Ser Lys Gly Ser  Ser Ser Leu 
    2210                 2215                 2220             


Asp Arg  Leu Tyr Ser Arg Lys  Ile Arg Lys Gln Leu  Val His His 
    2225                 2230                 2235             


Lys Gln  Gln Leu Asn Leu Leu  Lys Ala Lys Gln Lys  Ala Leu Val 
    2240                 2245                 2250             


Glu Gln  Met Glu Lys Glu Lys  Ile Gln Ser Asn Lys  Gly Ser Ser 
    2255                 2260                 2265             


Tyr Lys  Leu Leu Val Glu Gln  Ala Lys Leu Lys Gln  Ala Xaa Ser 
    2270                 2275                 2280             


Lys His  Phe Lys Asp Leu Ile  Arg Leu Arg Arg Xaa  Ala Glu Trp 
    2285                 2290                 2295             


Ser Arg  Ser Asn Leu Asp Xaa  Glu Val Xaa Xaa Ala  Lys Glu Ser 
    2300                 2305                 2310             


Pro Glu  Ile Glu Pro Leu Pro  Phe Xaa Leu Ala His  Glu Arg Cys 
    2315                 2320                 2325             


Ile Ser  Val Val Gln Lys Leu  Val Leu Phe Leu Leu  Ser Met Asp 
    2330                 2335                 2340             


Phe Xaa  Cys His Ala Asp Leu  Leu Leu Phe Val Cys  Lys Val Leu 
    2345                 2350                 2355             


Ala Arg  Ile Ala Asn Ala Xaa  Arg Pro Xaa Ile His  Leu Cys Glu 
    2360                 2365                 2370             


Ile Val  Asn Glu Pro Gln Leu  Glu Arg Leu Leu Leu  Leu Leu Val 
    2375                 2380                 2385             


Gly Xaa  Asp Phe Asn Arg Gly  Asp Ile Ser Trp Gly  Gly Ala Trp 
    2390                 2395                 2400             


Ala Gln  Tyr Ser Leu Xaa Cys  Met Leu Gln Asp Ile  Leu Ala Gly 
    2405                 2410                 2415             


Glu Leu  Leu Ala Pro Val Ala  Ala Glu Ala Met Glu  Glu Gly Xaa 
    2420                 2425                 2430             


Val Gly  Asp Asp Val Gly Ala  Xaa Ala Gly Asp Ser  Asp Asp Ser 
    2435                 2440                 2445             


Leu Gln  Gln Ser Ser Val Gln  Leu Leu Glu Xaa Ile  Asp Glu Pro 
    2450                 2455                 2460             


Leu Xaa  His Asp Ile Xaa Gly  Ala Pro Pro Leu Ser  Ser Leu Glu 
    2465                 2470                 2475             


Lys Asp  Lys Glu Ile Asp Leu  Glu Leu Leu Gln Asp  Leu Met Glu 
    2480                 2485                 2490             


Val Asp  Ile Asp Pro Leu Asp  Ile Asp Leu Glu Lys  Asp Pro Leu 
    2495                 2500                 2505             


Ala Ala  Lys Val Phe Lys Pro  Ile Ser Ser Xaa Trp  Tyr Asp Tyr 
    2510                 2515                 2520             


Trp Gly  Ala Asp Tyr Gly Xaa  Tyr Asn Tyr Asn Pro  Tyr Ile Gly 
    2525                 2530                 2535             


Gly Leu  Gly Ile Pro Val Ala  Lys Pro Pro Ala Asn  Xaa Glu Lys 
    2540                 2545                 2550             


Asn Gly  Ser Gln Xaa Val Ser  Val Ser Val Ser Gln  Ala Leu Asp 
    2555                 2560                 2565             


Ala Arg  Leu Glu Val Gly Leu  Glu Gln Gln Ala Glu  Leu Met Leu 
    2570                 2575                 2580             


Lys Met  Met Ser Xaa Leu Glu  Ala Asp Ser Ile Leu  Gln Ala Leu 
    2585                 2590                 2595             


Xaa Asn  Xaa Ser Pro Xaa Leu  Ser Gln Ser Pro Xaa  Gly Xaa Asp 
    2600                 2605                 2610             


Asp Ser  Leu Leu Gly Gly Leu  Gln Ala Ala Asn Gln  Xaa Ser Gln 
    2615                 2620                 2625             


Leu Ile  Ile Gln Leu Ser Ser  Val Pro Met Leu Asn  Val Cys Phe 
    2630                 2635                 2640             


Asn Lys  Leu Phe Ser Met Leu  Gln Val His His Val  Gln Leu Glu 
    2645                 2650                 2655             


Ser Leu  Leu Gln Leu Trp Leu  Xaa Leu Ser Leu Asn  Ser Ser Ser 
    2660                 2665                 2670             


Xaa Gly  Asn Lys Glu Asn Gly  Ala Asp Ile Phe Leu  Tyr Asn Ala 
    2675                 2680                 2685             


Asn Arg  Ile Pro Val Ile Ser  Leu Asn Gln Ala Ser  Ile Xaa Ser 
    2690                 2695                 2700             


Phe Leu  Xaa Val Leu Ala Trp  Tyr Pro Asn Xaa Leu  Leu Arg Xaa 
    2705                 2710                 2715             


Trp Cys  Leu Val Leu His Ser  Leu Xaa Leu Met Xaa  Asn Met Gln 
    2720                 2725                 2730             


Leu Asn  Ser Gly Ser Ser Ser  Ala Ile Gly Xaa Gln  Glu Ser Xaa 
    2735                 2740                 2745             


Ala His  Leu Leu Val Ser Asp  Pro Asn Leu Ile His  Val Leu Val 
    2750                 2755                 2760             


Lys Phe  Leu Ser Gly Xaa Ser  Pro His Gly Xaa Asn  Gln His Ser 
    2765                 2770                 2775             


Pro Gln  Val Gly Pro Xaa Ala  Xaa Gln Ala Met Gln  Glu Phe Leu 
    2780                 2785                 2790             


Xaa Arg  Leu Gln Val His Leu  Ser Ser Xaa Cys Pro  Gln Ile Phe 
    2795                 2800                 2805             


Ser Glu  Phe Leu Leu Lys Leu  Ile His Ile Leu Ser  Xaa Glu Arg 
    2810                 2815                 2820             


Gly Ala  Phe Gln Xaa Gly Gln  Gly Pro Leu Asp Ala  Gln Val Lys 
    2825                 2830                 2835             


Leu Leu  Glu Phe Xaa Leu Glu  Gln Asn Phe Glu Val  Val Ser Val 
    2840                 2845                 2850             


Ser Xaa  Ile Ser Ala Val Ile  Glu Ser Val Xaa Phe  Leu Val His 
    2855                 2860                 2865             


His Tyr  Ile Xaa Cys Ser Asp  Lys Val Met Ser Arg  Ser Gly Ser 
    2870                 2875                 2880             


Asp Ser  Ser Val Gly Ala Arg  Ala Cys Phe Gly Gly  Leu Phe Ala 
    2885                 2890                 2895             


Asn Leu  Ile Arg Pro Gly Asp  Ala Lys Ala Val Cys  Gly Glu Met 
    2900                 2905                 2910             


Xaa Arg  Asp Gln Leu Met Phe  Asp Leu Leu Lys Leu  Val Asn Ile 
    2915                 2920                 2925             


Leu Val  Gln Leu Pro Leu Ser  Gly Asn Arg Glu Tyr  Ser Ala Arg 
    2930                 2935                 2940             


Val Ser  Val Xaa Xaa Asn Xaa  Xaa Asp Ser Val Ser  Asp Glu Glu 
    2945                 2950                 2955             


Lys Val  Ser Gly Gly Lys Asp  Gly Asn Gly Ser Ser  Xaa Ser Val 
    2960                 2965                 2970             


Gln Gly  Ser Pro Ala Tyr Val  Ala Asp Leu Val Leu  Ala Asn Gln 
    2975                 2980                 2985             


Gln Ile  Met Ser Gln Ile Leu  Ser Ala Leu Gly Leu  Cys Asn Ser 
    2990                 2995                 3000             


Ser Ala  Met Ala Met Ile Ile  Gly Ala Ser Gly Leu  His Leu Xaa 
    3005                 3010                 3015             


Lys His  Glu Asn Phe His Gly  Gly Leu Asp Ala Ile  Ser Val Gly 
    3020                 3025                 3030             


Asp Gly  Leu Phe Xaa Ile Leu  Xaa Xaa Leu Ser Lys  Lys Ala Ser 
    3035                 3040                 3045             


Xaa Val  His Met Met Leu Gln  Pro Ile Leu Xaa Tyr  Met Ala Cys 
    3050                 3055                 3060             


Gly Tyr  Met Gly Arg Gln Gly  Ser Leu Ala Xaa Cys  Gln Leu Ser 
    3065                 3070                 3075             


Glu Pro  Leu Leu Trp Phe Ile  Leu Arg Val Leu Asp  Xaa Ser Asp 
    3080                 3085                 3090             


Ala Leu  Lys Ala Phe His Asp  Met Gly Gly Val Gln  Leu Ile Cys 
    3095                 3100                 3105             


Asn Asn  Met Val Xaa Ser Xaa  Arg Ala Ile Val Asn  Xaa Ala Arg 
    3110                 3115                 3120             


Ser Met  Val Ser Xaa Ile Met  Lys Phe Leu Asp Ser  Gly Pro Asn 
    3125                 3130                 3135             


Lys Ala  Val Asp Ser Xaa Leu  Lys Xaa Arg Ile Leu  Ala Ser Glu 
    3140                 3145                 3150             


Pro Asp  Asn Ala Glu Gly Ile  His Asn Phe Ala Pro  Leu Gly Xaa 
    3155                 3160                 3165             


Ile Xaa  Ser Ser Ser Pro Xaa  Ala Gln Pro Ala Glu  Val Leu Leu 
    3170                 3175                 3180             


Gln Ala  Xaa Pro Pro His Arg  Arg Ala Arg Ser Ala  Ala Trp Ser 
    3185                 3190                 3195             


Tyr Ile  Phe Leu Pro Glu Glu  Ala Trp Cys Asp Leu  Xaa Ile His 
    3200                 3205                 3210             


Leu Pro  Ala Ala Val Leu Leu  Lys Glu Ile His Ile  Gln Pro His 
    3215                 3220                 3225             


Leu Ala  Ser Leu Ala Xaa Cys  Pro Ser Ser Val Ser  Val Glu Val 
    3230                 3235                 3240             


Ser Ala  Asp Gly Val Asn Met  Leu Pro Leu Ser Xaa  Pro Val Val 
    3245                 3250                 3255             


Xaa Ser  Gly Leu Xaa Tyr Ile  Lys Ile Gln Leu Val  Lys Ala Glu 
    3260                 3265                 3270             


Val Ala  Ser Ala Val Cys Leu  Arg Leu His Arg Pro  Arg Asp Ala 
    3275                 3280                 3285             


Ser Xaa  Leu Gly Leu Ser Gln  Ile Lys Leu Leu Gly  Leu Xaa Ala 
    3290                 3295                 3300             


Phe Gly  Xaa Xaa Ser Ser Ala  Xaa Val Asn Asn Pro  Phe Leu Pro 
    3305                 3310                 3315             


Ser Glu  Asp Gln Val Ser Lys  Xaa Ser Ile Gly Trp  Leu Arg Leu 
    3320                 3325                 3330             


Leu His  His Cys Leu Xaa His  Ile Ser Asp Leu Glu  Gly Met Met 
    3335                 3340                 3345             


Ala Ser  Ala Ala Ala Pro Xaa  Ala Asn Leu Leu Gln  Xaa Cys Ala 
    3350                 3355                 3360             


Ala Leu  Leu Met Ser Pro Tyr  Cys Gly Met His Ser  Pro Asn Ile 
    3365                 3370                 3375             


Glu Val  Val Leu Val Lys Ile  Gly Leu Gln Ser Xaa  Arg Ile Gly 
    3380                 3385                 3390             


Leu Lys  Leu Ile Asp Ile Leu  Leu Arg Asn Cys Ala  Ala Ser Gly 
    3395                 3400                 3405             


Ser Asp  Pro Xaa Asp Leu Asn  Ser Pro Leu Leu Phe  Gly Arg Leu 
    3410                 3415                 3420             


Asn Gly  Leu Ser Ser Asp Ser  Xaa Ile Asp Ile Leu  Tyr Gln Leu 
    3425                 3430                 3435             


Gly Xaa  Xaa Gln Asp Pro Gly  Xaa Lys Asp Arg Ile  Gln Ala Leu 
    3440                 3445                 3450             


Leu Lys  Trp Val Ser Asp Ser  Ala Arg Val Ala Ala  Met Lys Arg 
    3455                 3460                 3465             


Ser Gly  Arg Met Asn Tyr Met  Cys Pro Asn Ser Ser  Xaa Val Glu 
    3470                 3475                 3480             


Tyr Gly  Leu Leu Met Pro Ser  Pro Ser His Leu His  Cys Val Ala 
    3485                 3490                 3495             


Ala Ile  Leu Trp His Ser Tyr  Glu Leu Leu Val Glu  Tyr Asp Leu 
    3500                 3505                 3510             


Pro Ala  Leu Leu Asp Gln Glu  Leu Phe Glu Leu Leu  Phe Asn Trp 
    3515                 3520                 3525             


Ser Met  Ser Leu Pro Cys Asn  Met Val Leu Lys Lys  Ala Val Asp 
    3530                 3535                 3540             


Ser Leu  Leu Cys Ser Met Cys  His Val His Pro Asn  Tyr Phe Ser 
    3545                 3550                 3555             


Leu Leu  Met Gly Trp Met Gly  Ile Xaa Pro Pro Pro  Val Gln Cys 
    3560                 3565                 3570             


His His  Arg Leu Ser Met Xaa  Asp Asp Ser Lys Lys  Gln Asp Leu 
    3575                 3580                 3585             


Ser Ser  Ser Leu Xaa Asp Asp  Ser Lys Asn Ala Gln  Ala Pro Leu 
    3590                 3595                 3600             


Ala Leu  Xaa Glu Ser His Leu  Ala Xaa Leu Ala Ser  Ser Ser Gln 
    3605                 3610                 3615             


Ser Pro  Glu Ala Ile Lys Gln  Leu Leu Asp Ser Gly  Leu Pro Ser 
    3620                 3625                 3630             


Leu Leu  Val Arg Ser Leu Ala  Ser Phe Cys Phe Ser  His Ile Ser 
    3635                 3640                 3645             


Ser Ser  Glu Ser Ile Ala Gln  Ser Ile Asp Ile Ser  Gln Asp Lys 
    3650                 3655                 3660             


Leu Arg  Arg His His Val Pro  Gln Gln Cys Asn Lys  Met Pro Ile 
    3665                 3670                 3675             


Xaa Ala  Asp Leu Val Ala Pro  Ile Leu Arg Phe Leu  Xaa Glu Val 
    3680                 3685                 3690             


Gly Asn  Ser His Ile Met Lys  Asp Trp Leu Gly Gly  Ser Glu Val 
    3695                 3700                 3705             


Asn Pro  Leu Trp Xaa Ala Leu  Leu Phe Leu Leu Cys  His Ser Gly 
    3710                 3715                 3720             


Ser Xaa  Ser Gly Ser His Asn  Leu Gly Ala Gln Gln  Xaa Ser Ala 
    3725                 3730                 3735             


Arg Ser  Ala Ser Leu Ser Ser  Ala Ala Xaa Xaa Gly  Leu Xaa Xaa 
    3740                 3745                 3750             


Gln Gln  Arg Xaa Ala Ile Glu  Asn Ala Xaa Val Ala  Phe Phe Leu 
    3755                 3760                 3765             


Gln Cys  Ile Ser Cys His Pro  Asn Asn Gln Lys Leu  Met Ala Gln 
    3770                 3775                 3780             


Val Leu  Cys Glu Leu Phe Gln  Xaa Ser Pro Gln Arg  Gly Asn Leu 
    3785                 3790                 3795             


Pro Xaa  Ser Gly Asn Ile Ser  Gly Phe Ile Arg Arg  Leu Phe Leu 
    3800                 3805                 3810             


Gln Leu  Met Leu Glu Asp Glu  Lys Val Xaa Met Phe  Leu Gln Ser 
    3815                 3820                 3825             


Pro Cys  Pro Leu Tyr Lys Gly  Arg Ile Asn Ala Xaa  Ser His Val 
    3830                 3835                 3840             


Ile Gln  His Pro Met Tyr Gly  Ala Gly His Lys Phe  Arg Xaa Leu 
    3845                 3850                 3855             


His Leu  Pro Val Ser Xaa Xaa  Leu Ser Asp Val Leu  Asp Arg Val 
    3860                 3865                 3870             


Ser Asp  Xaa Pro Ser Ile Xaa  Ala Lys Leu Ile Ser  Glu Gln Lys 
    3875                 3880                 3885             


Asp Asp  Lys Glu Lys Lys Asn  His Glu Glu Lys Glu  Lys Val Lys 
    3890                 3895                 3900             


Ala Glu  Asn Gly Phe Gln Asp  Asn Tyr Ser Val Val  Val Ala Ser 
    3905                 3910                 3915             


Gly Leu  Lys Ser Gln Ser Lys  Arg Ala Val Ser Ala  Xaa Pro Pro 
    3920                 3925                 3930             


Arg Pro  Pro Ser Arg Arg Gly  Arg Xaa Ile Pro Asp  Lys Ile Gly 
    3935                 3940                 3945             


Ser Xaa  Ser Gly Ala Glu Ala  Ala Asn Lys Ile Ile  Xaa Val Pro 
    3950                 3955                 3960             


Val Phe  His Leu Phe His Lys  Leu Leu Ala Gly Gln  Pro Leu Pro 
    3965                 3970                 3975             


Ala Glu  Met Xaa Leu Ala Gln  Leu Leu Xaa Leu Leu  Tyr Asp Arg 
    3980                 3985                 3990             


Lys Leu  Pro Gln Gly Tyr Arg  Ser Ile Asp Leu Xaa  Val Lys Leu 
    3995                 4000                 4005             


Gly Ser  Arg Val Ile Xaa Asp  Pro Ser Leu Ser Lys  Xaa Asp Ser 
    4010                 4015                 4020             


Tyr Lys  Arg Leu His Pro Glu  Lys Asp His Gly Asp  Leu Leu Ala 
    4025                 4030                 4035             


Ser Cys  Pro Glu Asp Glu Ala  Leu Xaa Pro Gly Asp  Glu Cys Met 
    4040                 4045                 4050             


Asp Gly  Ile Leu Asp Glu Ser  Leu Leu Glu Xaa Cys  Pro Ile Gln 
    4055                 4060                 4065             


Ser Pro  Leu Gln Val Phe Ala  Gly Met Gly Gly Leu  Ala Leu Ile 
    4070                 4075                 4080             


Ala Glu  Arg Leu Pro Met Leu  Tyr Pro Glu Val Ile  Gln Gln Val 
    4085                 4090                 4095             


Ser Ala  Pro Val Val Xaa Ser  Xaa Xaa Gln Glu Lys  Pro Lys Asp 
    4100                 4105                 4110             


Ser Asp  Gln Phe Glu Trp Val  Xaa Ile Glu Gln Ser  Gly Glu Leu 
    4115                 4120                 4125             


Val Tyr  Glu Ala Pro Glu Xaa  Val Ala Ala Glu Pro  Pro Pro Ile 
    4130                 4135                 4140             


Lys Ser  Ala Val Gln Xaa Met  Ser Pro Ile Pro Ala  His Ser Leu 
    4145                 4150                 4155             


Ala Ala  Phe Gly Leu Phe Leu  Arg Leu Pro Gly Tyr  Ala Glu Val 
    4160                 4165                 4170             


Leu Leu  Lys Glu Arg Lys His  Ala Gln Cys Leu Leu  Arg Leu Val 
    4175                 4180                 4185             


Leu Gly  Val Xaa Asp Asp Gly  Glu Gly Ser His Ile  Leu Gln Ser 
    4190                 4195                 4200             


Pro Ser  Ala Asn Val Leu Pro  Xaa Leu Pro Phe His  Val Leu Arg 
    4205                 4210                 4215             


Ser Leu  Phe Ser Xaa Xaa Pro  Leu Xaa Xaa Asp Asp  Gly Val Leu 
    4220                 4225                 4230             


Leu Arg  Arg Met Ala Leu Glu  Ile Gly Ala Leu His  Leu Ile Leu 
    4235                 4240                 4245             


Val Cys  Leu Ser Ala Leu Ser  His His Ser Pro Arg  Val Pro Asn 
    4250                 4255                 4260             


Ser Ser  Val Asn Gln Xaa Glu  Pro Gln Val Ser Ser  Ser His Asn 
    4265                 4270                 4275             


Pro Xaa  Ser Xaa Glu Glu Gln  Gln Leu Tyr Trp Ala  Lys Gly Xaa 
    4280                 4285                 4290             


Gly Phe  Gly Xaa Gly Ser Xaa  Ala Ser Gly Trp Asp  Val Glu Gln 
    4295                 4300                 4305             


Ala Leu  Xaa Lys Gln Arg Leu  Glu Glu Glu His Val  Xaa Cys Leu 
    4310                 4315                 4320             


Leu Gln  Val Leu Ala Ser Tyr  Ile Asn Pro Val Ser  Ser Ala Val 
    4325                 4330                 4335             


Asn Gly  Glu Ala Gln Ser Ser  His Glu Xaa Arg Gly  Gln Asn Ser 
    4340                 4345                 4350             


Asn Ala  Leu Pro Ser Val Leu  Leu Glu Leu Leu Ser  Gln Ser Cys 
    4355                 4360                 4365             


Leu Ile  Pro Ala Met Ser Ser  Tyr Leu Arg Asn Asp  Ser Val Leu 
    4370                 4375                 4380             


Asp Met  Ala Arg His Val Pro  Leu Tyr Arg Ala Leu  Leu Glu Leu 
    4385                 4390                 4395             


Leu Arg  Ala Ile Ala Ser Cys  Ala Ala Met Val Pro  Leu Leu Leu 
    4400                 4405                 4410             


Pro Leu  Ser Xaa Glu Asn Gly  Glu Glu Glu Glu Glu  Gln Ser Glu 
    4415                 4420                 4425             


Cys Gln  Xaa Ser Val Gly Xaa  Leu Leu Ala Lys Met  Lys Xaa Cys 
    4430                 4435                 4440             


Val Asp  Xaa Tyr Xaa Asn Arg  Leu Arg Ser Lys Arg  Glu Asn Val 
    4445                 4450                 4455             


Lys Xaa  Gly Val Lys Pro Asp  Ala Ser Asp Gln Glu  Pro Glu Gly 
    4460                 4465                 4470             


Leu Xaa  Leu Leu Val Pro Asp  Ile Gln Lys Xaa Ala  Glu Ile Val 
    4475                 4480                 4485             


Tyr Ala  Ala Xaa Xaa Ser Leu  Arg Gln Ala Asn Gln  Glu Lys Lys 
    4490                 4495                 4500             


Leu Gly  Glu Tyr Ser Lys Lys  Ala Ala Met Lys Pro  Lys Pro Leu 
    4505                 4510                 4515             


Ser Val  Leu Lys Ser Leu Glu  Glu Lys Tyr Val Ala  Val Met Lys 
    4520                 4525                 4530             


Lys Leu  Gln Phe Asp Xaa Phe  Glu Met Val Ser Glu  Asp Glu Asp 
    4535                 4540                 4545             


Gly Lys  Leu Gly Phe Lys Val  Asn Tyr His Tyr Met  Ser Gln Val 
    4550                 4555                 4560             


Lys Asn  Ala Asn Asp Ala Asn  Ser Ala Ala Arg Ala  Arg Arg Leu 
    4565                 4570                 4575             


Ala Gln  Glu Ala Val Xaa Leu  Ser Xaa Ser Leu Pro  Leu Ser Ser 
    4580                 4585                 4590             


Ser Ser  Ser Val Phe Val Arg  Cys Asp Glu Glu Arg  Leu Asp Ile 
    4595                 4600                 4605             


Met Lys  Val Leu Ile Xaa Gly  Pro Ala Asp Xaa Pro  Tyr Ala Asn 
    4610                 4615                 4620             


Gly Cys  Phe Glu Phe Asp Val  Tyr Phe Pro Gln Asp  Tyr Pro Ser 
    4625                 4630                 4635             


Ser Pro  Pro Leu Val Asn Leu  Glu Xaa Xaa Gly Gly  His Ser Val 
    4640                 4645                 4650             


Arg Phe  Asn Pro Asn Leu Tyr  Asn Asp Gly Lys Val  Cys Leu Ser 
    4655                 4660                 4665             


Ile Leu  Asn Xaa Trp His Gly  Arg Pro Glu Glu Lys  Trp Asn Pro 
    4670                 4675                 4680             


Gln Xaa  Ser Ser Phe Leu Gln  Val Leu Val Ser Val  Gln Ser Leu 
    4685                 4690                 4695             


Ile Leu  Val Ala Glu Pro Tyr  Phe Asn Glu Pro Gly  Tyr Glu Arg 
    4700                 4705                 4710             


Ser Arg  Gly Xaa Pro Ser Gly  Xaa Gln Ser Ser Arg  Glu Tyr Asp 
    4715                 4720                 4725             


Gly Asn  Ile Arg Gln Ala Xaa  Val Lys Trp Ala Met  Leu Glu Gln 
    4730                 4735                 4740             


Ile Arg  Asn Pro Ser Pro Cys  Phe Lys Glu Val Ile  His Lys His 
    4745                 4750                 4755             


Phe Tyr  Leu Lys Arg Val Glu  Ile Met Ala Gln Cys  Glu Glu Trp 
    4760                 4765                 4770             


Ile Ala  Asp Ile Gln Gln Tyr  Ser Ser Asp Lys Arg  Val Gly Arg 
    4775                 4780                 4785             


Xaa Met  Ser His His Ala Ala  Ala Leu Lys Arg His  Xaa Ala Gln 
    4790                 4795                 4800             


Leu Arg  Glu Glu Leu Leu Lys  Leu Pro Cys Pro Glu  Gly Leu Asp 
    4805                 4810                 4815             


Pro Asp  Xaa Asp Asp Ala Pro  Glu Val Cys Arg Ala  Xaa Xaa Gly 
    4820                 4825                 4830             


Ala Glu  Glu Xaa Leu Met His  Asp Gln Val Lys Pro  Ser Ser Ser 
    4835                 4840                 4845             


Lys Glu  Leu Pro Ser Asp Phe  Gln Leu 
    4850                 4855         


<210> 4225
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<400> 4225
Ser Trp Asp Glu His Val Phe Glu Leu Val Leu Pro Lys Ala Cys Met 
1               5                   10                  15      


Val Gly His Val Asp Phe Lys Phe Val Leu Asn Ser Asn Ile Xaa Asn 
            20                  25                  30          


Ile Pro Gln Ile Gln Val Xaa Leu Leu Lys Asn Lys Ala Pro Gly Leu 
        35                  40                  45              


Gly Lys Val Asn Gly Leu Arg Leu Cys Pro Phe Leu Glu Asp His Lys 
    50                  55                  60                  


Glu Asp Ile Leu Cys Gly Pro Val Trp Leu Ala Ser Gly Leu Asp Leu 
65                  70                  75                  80  


Ser Gly His Ala Gly Met Leu Xaa Leu Xaa Ser Pro Lys Leu Val Lys 
                85                  90                  95      


Gly Met Ala Gly Gly Lys Tyr Arg Ser Phe Leu Ile His Val Lys Ala 
            100                 105                 110         


Val Asn Glu Arg Gly Xaa Glu Glu Ile Cys Asn Gly Gly Met Arg Pro 
        115                 120                 125             


Val Val Arg Leu Pro Ser Leu Lys His Gln Ser Asn Lys Gly Tyr Ser 
    130                 135                 140                 


Leu Ala Ser Leu Leu Ala Lys Val Ala Ala Gly Lys Glu Lys Ser Ser 
145                 150                 155                 160 


Asn Val Lys Asn Glu Asn Xaa Ser Gly Xaa Arg Lys Ser Glu Asn Leu 
                165                 170                 175     


Arg Gly Cys Asp Leu Leu Gln Glu Val Ser Val Xaa Ile Arg Arg 
            180                 185                 190     


<210> 4226
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<400> 4226
Xaa Glu Asp His Lys Glu Asp Ile Leu Cys Gly Pro Val Trp Leu Ala 
1               5                   10                  15      


Ser Gly Leu Asp Leu Ser Gly His Ala Gly Met Leu Xaa Leu Xaa Ser 
            20                  25                  30          


Pro Lys Leu Val Lys Gly Met Ala Gly Gly Lys Tyr Arg Ser Phe Leu 
        35                  40                  45              


Ile His Val Lys Ala Val Asn Glu Arg Gly Xaa Glu Glu Ile Cys Asn 
    50                  55                  60                  


Gly Gly Met Arg Pro Val Val Arg Leu Pro Ser Leu Lys His Gln Ser 
65                  70                  75                  80  


Asn Lys Gly Tyr Ser Leu Ala Ser Leu Leu Ala Lys Val Ala Ala Gly 
                85                  90                  95      


Lys Ser Ala Xaa Met Cys His Val Xaa Val Phe Arg Ile Ser 
            100                 105                 110 


<210> 4227
<211> 280
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<400> 4227
Met Gly Pro Lys Asp Ser Ala Lys Cys Leu His Arg Gly Pro Gln Pro 
1               5                   10                  15      


Ser His Trp Ala Ala Gly Asp Gly Pro Xaa Gln Glu Arg Cys Gly Pro 
            20                  25                  30          


Arg Ser Leu Gly Ser Pro Val Leu Gly Leu Asp Xaa Cys Arg Ala Trp 
        35                  40                  45              


Asp His Val Asp Gly Gln Ile Leu Gly Gln Leu Arg Pro Leu Xaa Glu 
    50                  55                  60                  


Glu Glu Glu Glu Glu Gly Ala Gly Ala Xaa Leu Ser Arg Gly Pro Ala 
65                  70                  75                  80  


Phe Pro Gly Met Gly Ser Glu Glu Leu Arg Leu Ala Ser Phe Tyr Asp 
                85                  90                  95      


Trp Pro Leu Xaa Ala Glu Val Pro Pro Glu Leu Leu Ala Ala Ala Gly 
            100                 105                 110         


Phe Phe His Xaa Gly His Gln Asp Lys Val Arg Cys Phe Phe Cys Tyr 
        115                 120                 125             


Gly Gly Leu Gln Ser Trp Lys Arg Gly Asp Asp Pro Trp Xaa Glu His 
    130                 135                 140                 


Ala Lys Trp Phe Pro Ser Cys Gln Phe Leu Leu Arg Ser Lys Gly Arg 
145                 150                 155                 160 


Asp Phe Val His Ser Val Gln Glu Xaa His Ser Gln Leu Leu Gly Ser 
                165                 170                 175     


Trp Asp Pro Trp Glu Glu Pro Glu Asp Ala Ala Pro Val Ala Pro Ser 
            180                 185                 190         


Val Pro Ala Ser Gly Tyr Pro Glu Leu Pro Xaa Pro Arg Arg Glu Val 
        195                 200                 205             


Gln Ser Glu Ser Ala Gln Glu Pro Gly Ala Arg Asp Val Glu Ala Gln 
    210                 215                 220                 


Leu Arg Arg Leu Gln Glu Glu Arg Xaa Cys Lys Val Cys Leu Asp Arg 
225                 230                 235                 240 


Ala Val Ser Ile Val Phe Val Pro Cys Gly His Leu Val Cys Ala Glu 
                245                 250                 255     


Cys Ala Pro Gly Leu Gln Leu Cys Pro Ile Cys Arg Ala Pro Val Arg 
            260                 265                 270         


Ser Arg Val Arg Xaa Phe Leu Ser 
        275                 280 


<210> 4228
<211> 298
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<400> 4228
Met Gly Pro Lys Asp Ser Ala Lys Cys Leu His Arg Gly Pro Gln Pro 
1               5                   10                  15      


Ser His Trp Ala Ala Gly Asp Gly Pro Xaa Gln Glu Arg Cys Gly Pro 
            20                  25                  30          


Arg Ser Leu Gly Ser Pro Val Leu Gly Leu Asp Xaa Cys Arg Ala Trp 
        35                  40                  45              


Asp His Val Asp Gly Gln Ile Leu Gly Gln Leu Arg Pro Leu Xaa Glu 
    50                  55                  60                  


Glu Glu Glu Glu Glu Gly Ala Gly Ala Xaa Leu Ser Arg Gly Pro Ala 
65                  70                  75                  80  


Phe Pro Gly Met Gly Ser Glu Glu Leu Arg Leu Ala Ser Phe Tyr Asp 
                85                  90                  95      


Trp Pro Leu Xaa Ala Glu Val Pro Pro Glu Leu Leu Ala Ala Ala Gly 
            100                 105                 110         


Phe Phe His Xaa Gly His Gln Asp Lys Val Arg Cys Phe Phe Cys Tyr 
        115                 120                 125             


Gly Gly Leu Gln Ser Trp Lys Arg Gly Asp Asp Pro Trp Xaa Glu His 
    130                 135                 140                 


Ala Lys Trp Phe Pro Ser Cys Gln Phe Leu Leu Arg Ser Lys Gly Arg 
145                 150                 155                 160 


Asp Phe Val His Ser Val Gln Glu Xaa His Ser Gln Leu Leu Gly Ser 
                165                 170                 175     


Trp Asp Pro Trp Glu Glu Pro Glu Asp Ala Ala Pro Val Ala Pro Ser 
            180                 185                 190         


Val Pro Ala Ser Gly Tyr Pro Glu Leu Pro Xaa Pro Arg Arg Glu Val 
        195                 200                 205             


Gln Ser Glu Ser Ala Gln Glu Pro Gly Gly Val Ser Pro Ala Glu Ala 
    210                 215                 220                 


Gln Arg Ala Trp Trp Val Leu Glu Pro Pro Gly Ala Arg Asp Val Glu 
225                 230                 235                 240 


Ala Gln Leu Arg Arg Leu Gln Glu Glu Arg Xaa Cys Lys Val Cys Leu 
                245                 250                 255     


Asp Arg Ala Val Ser Ile Val Phe Val Pro Cys Gly His Leu Val Cys 
            260                 265                 270         


Ala Glu Cys Ala Pro Gly Leu Gln Leu Cys Pro Ile Cys Arg Ala Pro 
        275                 280                 285             


Val Arg Ser Arg Val Arg Xaa Phe Leu Ser 
    290                 295             


<210> 4229
<211> 193
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<400> 4229
Met Pro Leu Pro Trp Asp Tyr Pro Glu Ala Pro Trp Arg Arg Leu His 
1               5                   10                  15      


Ser Ser Pro Pro Arg Pro Cys Pro Arg Ala Leu Gln Gly Gly Gly Arg 
            20                  25                  30          


Arg Gly Pro Asn Pro Asp Pro Arg Gly Ser Lys Gly Leu Lys Gln Xaa 
        35                  40                  45              


Val Gly Ala Leu Asn Pro Asn Leu His Leu Trp Gly Ile Cys Ser Cys 
    50                  55                  60                  


Gln Phe Leu Leu Arg Ser Lys Gly Arg Asp Phe Val His Ser Val Gln 
65                  70                  75                  80  


Glu Xaa His Ser Gln Leu Leu Gly Ser Trp Asp Pro Trp Glu Glu Pro 
                85                  90                  95      


Glu Asp Ala Ala Pro Val Ala Pro Ser Val Pro Ala Ser Gly Tyr Pro 
            100                 105                 110         


Glu Leu Pro Xaa Pro Arg Arg Glu Val Gln Ser Glu Ser Ala Gln Glu 
        115                 120                 125             


Pro Gly Ala Arg Asp Val Glu Ala Gln Leu Arg Arg Leu Gln Glu Glu 
    130                 135                 140                 


Arg Xaa Cys Lys Val Cys Leu Asp Arg Ala Val Ser Ile Val Phe Val 
145                 150                 155                 160 


Pro Cys Gly His Leu Val Cys Ala Glu Cys Ala Pro Gly Leu Gln Leu 
                165                 170                 175     


Cys Pro Ile Cys Arg Ala Pro Val Arg Ser Arg Val Arg Xaa Phe Leu 
            180                 185                 190         


Ser 
    


<210> 4230
<211> 236
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<400> 4230
Met Xaa Gly Tyr Glu Ala Arg Leu Ile Xaa Phe Gly Xaa Trp Met Tyr 
1               5                   10                  15      


Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly Phe Tyr Ala Ile Gly 
            20                  25                  30          


Gln Glu Asp Lys Val Gln Cys Phe His Cys Gly Gly Gly Leu Ala Asn 
        35                  40                  45              


Trp Lys Pro Lys Glu Asp Pro Trp Glu Gln His Ala Lys Trp Tyr Pro 
    50                  55                  60                  


Gly Cys Lys Tyr Leu Leu Glu Glu Lys Gly His Glu Tyr Ile Asn Asn 
65                  70                  75                  80  


Ile His Leu Xaa Arg Ser Leu Glu Gly Ala Leu Val Gln Xaa Xaa Lys 
                85                  90                  95      


Lys Xaa Pro Ser Leu Xaa Lys Arg Ile Ser Asp Xaa Ile Phe Pro Asn 
            100                 105                 110         


Pro Met Leu Gln Glu Ala Ile Arg Met Gly Phe Asp Phe Lys Asp Val 
        115                 120                 125             


Lys Lys Ile Met Glu Glu Arg Ile Gln Xaa Ser Gly Ser Asn Tyr Lys 
    130                 135                 140                 


Xaa Leu Glu Val Leu Val Ala Asp Leu Val Ser Ala Gln Lys Asp Xaa 
145                 150                 155                 160 


Xaa Glu Asn Glu Leu Asn Gln Xaa Ser Leu Gln Arg Glu Ile Ser Pro 
                165                 170                 175     


Glu Glu Pro Leu Arg Arg Leu Gln Glu Glu Lys Leu Cys Lys Ile Cys 
            180                 185                 190         


Met Asp Arg His Ile Ala Val Val Phe Ile Pro Cys Gly His Leu Val 
        195                 200                 205             


Xaa Cys Lys Gln Cys Ala Glu Ala Val Asp Arg Cys Pro Met Cys Ser 
    210                 215                 220                 


Ala Val Ile Asp Phe Lys Gln Arg Val Phe Met Ser 
225                 230                 235     


<210> 4231
<211> 505
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<400> 4231
Met Gly Leu Val Ser Ser Lys Lys Pro Asp Lys Glu Lys Pro Ile Lys 
1               5                   10                  15      


Glu Lys Asp Lys Gly Gln Trp Ser Pro Leu Lys Val Ser Ala Gln Asp 
            20                  25                  30          


Lys Asp Ala Pro Pro Leu Pro Pro Leu Val Val Phe Asn His Leu Xaa 
        35                  40                  45              


Pro Pro Pro Pro Asp Glu His Leu Asp Glu Asp Lys His Phe Val Val 
    50                  55                  60                  


Ala Leu Tyr Asp Tyr Xaa Ala Met Asn Asp Arg Asp Leu Gln Met Leu 
65                  70                  75                  80  


Lys Gly Glu Lys Leu Gln Val Leu Lys Gly Xaa Gly Asp Trp Trp Leu 
                85                  90                  95      


Ala Arg Ser Leu Val Xaa Gly Arg Glu Gly Tyr Val Pro Ser Asn Phe 
            100                 105                 110         


Val Ala Arg Val Glu Ser Leu Glu Met Glu Arg Trp Phe Phe Arg Ser 
        115                 120                 125             


Gln Gly Arg Lys Glu Ala Glu Arg Gln Leu Leu Ala Pro Ile Asn Lys 
    130                 135                 140                 


Ala Gly Ser Phe Leu Ile Arg Glu Ser Glu Xaa Asn Lys Gly Ala Phe 
145                 150                 155                 160 


Ser Leu Ser Val Lys Asp Val Xaa Xaa Gln Gly Glu Leu Ile Lys His 
                165                 170                 175     


Tyr Lys Ile Arg Cys Leu Asp Glu Gly Gly Tyr Tyr Ile Ser Pro Arg 
            180                 185                 190         


Ile Xaa Phe Pro Ser Leu Gln Ala Leu Val Gln His Tyr Ser Lys Lys 
        195                 200                 205             


Gly Asp Gly Leu Cys Gln Arg Leu Xaa Leu Pro Cys Val Arg Pro Ala 
    210                 215                 220                 


Pro Gln Asn Pro Trp Ala Gln Asp Glu Trp Glu Ile Pro Arg Gln Ser 
225                 230                 235                 240 


Leu Arg Leu Val Arg Lys Leu Gly Ser Gly Gln Phe Gly Glu Val Trp 
                245                 250                 255     


Met Gly Tyr Tyr Lys Asn Asn Met Lys Val Ala Ile Lys Xaa Leu Lys 
            260                 265                 270         


Glu Gly Xaa Met Ser Pro Glu Ala Phe Leu Gly Glu Ala Asn Val Met 
        275                 280                 285             


Lys Ala Leu Gln His Glu Arg Leu Val Arg Leu Tyr Ala Val Val Xaa 
    290                 295                 300                 


Lys Glu Pro Ile Tyr Ile Val Xaa Glu Tyr Met Ala Arg Gly Cys Leu 
305                 310                 315                 320 


Leu Asp Phe Leu Lys Xaa Asp Glu Gly Ser Arg Leu Ser Leu Pro Arg 
                325                 330                 335     


Leu Ile Asp Met Ser Ala Gln Ile Ala Glu Gly Met Ala Tyr Ile Glu 
            340                 345                 350         


Arg Met Asn Ser Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val 
        355                 360                 365             


Ser Glu Ala Leu Cys Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Ile 
    370                 375                 380                 


Ile Asp Ser Glu Tyr Xaa Ala Gln Glu Gly Ala Lys Phe Pro Ile Lys 
385                 390                 395                 400 


Trp Xaa Ala Pro Glu Ala Ile His Phe Gly Val Phe Xaa Ile Lys Ala 
                405                 410                 415     


Asp Val Trp Ser Phe Gly Val Leu Leu Met Glu Val Val Xaa Tyr Gly 
            420                 425                 430         


Arg Val Pro Tyr Pro Gly Met Ser Asn Pro Glu Val Ile Arg Asn Leu 
        435                 440                 445             


Glu Arg Gly Tyr Arg Met Pro Arg Pro Asp Xaa Cys Pro Pro Glu Leu 
    450                 455                 460                 


Tyr Arg Gly Val Ile Ala Glu Cys Trp Arg Ser Arg Pro Glu Glu Arg 
465                 470                 475                 480 


Pro Xaa Phe Glu Phe Leu Gln Ser Val Leu Glu Asp Phe Tyr Xaa Ala 
                485                 490                 495     


Xaa Glu Arg Gln Tyr Glu Leu Gln Pro 
            500                 505 


<210> 4232
<211> 434
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<400> 4232
Met Asn Asp Arg Asp Leu Gln Met Leu Lys Gly Glu Lys Leu Gln Val 
1               5                   10                  15      


Leu Lys Gly Xaa Gly Asp Trp Trp Leu Ala Arg Ser Leu Val Xaa Gly 
            20                  25                  30          


Arg Glu Gly Tyr Val Pro Ser Asn Phe Val Ala Arg Val Glu Ser Leu 
        35                  40                  45              


Glu Met Glu Arg Trp Phe Phe Arg Ser Gln Gly Arg Lys Glu Ala Glu 
    50                  55                  60                  


Arg Gln Leu Leu Ala Pro Ile Asn Lys Ala Gly Ser Phe Leu Ile Arg 
65                  70                  75                  80  


Glu Ser Glu Xaa Asn Lys Gly Ala Phe Ser Leu Ser Val Lys Asp Val 
                85                  90                  95      


Xaa Xaa Gln Gly Glu Leu Ile Lys His Tyr Lys Ile Arg Cys Leu Asp 
            100                 105                 110         


Glu Gly Gly Tyr Tyr Ile Ser Pro Arg Ile Xaa Phe Pro Ser Leu Gln 
        115                 120                 125             


Ala Leu Val Gln His Tyr Ser Lys Lys Gly Asp Gly Leu Cys Gln Arg 
    130                 135                 140                 


Leu Xaa Leu Pro Cys Val Arg Pro Ala Pro Gln Asn Pro Trp Ala Gln 
145                 150                 155                 160 


Asp Glu Trp Glu Ile Pro Arg Gln Ser Leu Arg Leu Val Arg Lys Leu 
                165                 170                 175     


Gly Ser Gly Gln Phe Gly Glu Val Trp Met Gly Tyr Tyr Lys Asn Asn 
            180                 185                 190         


Met Lys Val Ala Ile Lys Xaa Leu Lys Glu Gly Xaa Met Ser Pro Glu 
        195                 200                 205             


Ala Phe Leu Gly Glu Ala Asn Val Met Lys Ala Leu Gln His Glu Arg 
    210                 215                 220                 


Leu Val Arg Leu Tyr Ala Val Val Xaa Lys Glu Pro Ile Tyr Ile Val 
225                 230                 235                 240 


Xaa Glu Tyr Met Ala Arg Gly Cys Leu Leu Asp Phe Leu Lys Xaa Asp 
                245                 250                 255     


Glu Gly Ser Arg Leu Ser Leu Pro Arg Leu Ile Asp Met Ser Ala Gln 
            260                 265                 270         


Ile Ala Glu Gly Met Ala Tyr Ile Glu Arg Met Asn Ser Ile His Arg 
        275                 280                 285             


Asp Leu Arg Ala Ala Asn Ile Leu Val Ser Glu Ala Leu Cys Cys Lys 
    290                 295                 300                 


Ile Ala Asp Phe Gly Leu Ala Arg Ile Ile Asp Ser Glu Tyr Xaa Ala 
305                 310                 315                 320 


Gln Glu Gly Ala Lys Phe Pro Ile Lys Trp Xaa Ala Pro Glu Ala Ile 
                325                 330                 335     


His Phe Gly Val Phe Xaa Ile Lys Ala Asp Val Trp Ser Phe Gly Val 
            340                 345                 350         


Leu Leu Met Glu Val Val Xaa Tyr Gly Arg Val Pro Tyr Pro Gly Met 
        355                 360                 365             


Ser Asn Pro Glu Val Ile Arg Asn Leu Glu Arg Gly Tyr Arg Met Pro 
    370                 375                 380                 


Arg Pro Asp Xaa Cys Pro Pro Glu Leu Tyr Arg Gly Val Ile Ala Glu 
385                 390                 395                 400 


Cys Trp Arg Ser Arg Pro Glu Glu Arg Pro Xaa Phe Glu Phe Leu Gln 
                405                 410                 415     


Ser Val Leu Glu Asp Phe Tyr Xaa Ala Xaa Glu Arg Gln Tyr Glu Leu 
            420                 425                 430         


Gln Pro 
        


<210> 4233
<211> 413
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(413)
<223> Selenocysteine

<400> 4233
Met Ala Ala Val Pro Gln Asn Asn Leu Gln Glu Gln Leu Glu Arg His 
1               5                   10                  15      


Ser Ala Arg Xaa Leu Asn Asn Lys Leu Ser Leu Ser Lys Pro Lys Phe 
            20                  25                  30          


Ser Gly Phe Xaa Phe Lys Lys Lys Xaa Ser Ser Asp Asn Asn Val Ser 
        35                  40                  45              


Val Xaa Asn Val Ser Val Ala Lys Xaa Pro Val Leu Arg Asn Lys Asp 
    50                  55                  60                  


Val Asn Val Xaa Glu Asp Phe Ser Phe Ser Glu Pro Leu Pro Asn Xaa 
65                  70                  75                  80  


Xaa Asn Gln Gln Arg Val Lys Asp Phe Phe Lys Asn Ala Pro Ala Gly 
                85                  90                  95      


Gln Glu Xaa Gln Arg Gly Gly Ser Lys Ser Leu Leu Pro Asp Phe Leu 
            100                 105                 110         


Gln Xaa Pro Lys Glu Val Val Cys Xaa Xaa Gln Asn Xaa Pro Xaa Val 
        115                 120                 125             


Lys Lys Ser Arg Asp Xaa Ala Leu Lys Lys Leu Glu Phe Ser Ser Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ser Xaa Ile Asn Asp Trp Asp Asp Met Asp Asp Phe 
145                 150                 155                 160 


Asp Xaa Ser Glu Xaa Ser Lys Ser Phe Val Xaa Pro Pro Gln Ser His 
                165                 170                 175     


Phe Val Arg Val Ser Xaa Ala Gln Lys Ser Lys Lys Gly Lys Arg Asn 
            180                 185                 190         


Phe Phe Lys Ala Gln Leu Tyr Xaa Xaa Asn Xaa Val Lys Xaa Asp Leu 
        195                 200                 205             


Pro Pro Pro Ser Ser Glu Ser Glu Gln Ile Asp Leu Xaa Glu Glu Gln 
    210                 215                 220                 


Lys Asp Asp Ser Glu Trp Leu Ser Ser Asp Val Ile Cys Ile Asp Asp 
225                 230                 235                 240 


Gly Pro Ile Ala Glu Val His Ile Asn Glu Asp Ala Gln Glu Ser Asp 
                245                 250                 255     


Ser Leu Lys Xaa His Leu Glu Asp Glu Arg Asp Asn Ser Glu Lys Lys 
            260                 265                 270         


Lys Asn Leu Glu Glu Ala Glu Leu His Ser Xaa Glu Lys Val Pro Cys 
        275                 280                 285             


Ile Glu Phe Asp Asp Asp Asp Tyr Asp Xaa Asp Phe Val Pro Pro Ser 
    290                 295                 300                 


Pro Glu Glu Ile Ile Ser Ala Ser Ser Ser Ser Ser Lys Cys Leu Ser 
305                 310                 315                 320 


Xaa Leu Lys Asp Leu Asp Xaa Ser Asp Arg Lys Glu Asp Val Leu Ser 
                325                 330                 335     


Xaa Ser Lys Asp Leu Leu Ser Lys Pro Glu Lys Met Ser Met Gln Glu 
            340                 345                 350         


Leu Asn Pro Glu Xaa Ser Xaa Asp Cys Asp Gly Ser His Cys Val Ala 
        355                 360                 365             


Gln Ala Gly Leu Glu Leu Leu Asp Leu Ser Asn Pro Pro Ala Leu Ala 
    370                 375                 380                 


Ser Pro Lys Gly Trp Asp Tyr Ser His Glu Pro Pro Cys Leu Ala Lys 
385                 390                 395                 400 


Xaa Phe Phe Phe Phe Pro Gln Arg Lys Ile Leu Xaa Xaa 
                405                 410             


<210> 4234
<211> 1286
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1240)..(1240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<400> 4234
Met Ala Ala Val Pro Gln Asn Asn Leu Gln Glu Gln Leu Glu Arg His 
1               5                   10                  15      


Ser Ala Arg Xaa Leu Asn Asn Lys Leu Ser Leu Ser Lys Pro Lys Phe 
            20                  25                  30          


Ser Gly Phe Xaa Phe Lys Lys Lys Xaa Ser Ser Asp Asn Asn Val Ser 
        35                  40                  45              


Val Xaa Asn Val Ser Val Ala Lys Xaa Pro Val Leu Arg Asn Lys Asp 
    50                  55                  60                  


Val Asn Val Xaa Glu Asp Phe Ser Phe Ser Glu Pro Leu Pro Asn Xaa 
65                  70                  75                  80  


Xaa Asn Gln Gln Arg Val Lys Asp Phe Phe Lys Asn Ala Pro Ala Gly 
                85                  90                  95      


Gln Glu Xaa Gln Arg Gly Gly Ser Lys Ser Leu Leu Pro Asp Phe Leu 
            100                 105                 110         


Gln Xaa Pro Lys Glu Val Val Cys Xaa Xaa Gln Asn Xaa Pro Xaa Val 
        115                 120                 125             


Lys Lys Ser Arg Asp Xaa Ala Leu Lys Lys Leu Glu Phe Ser Ser Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ser Xaa Ile Asn Asp Trp Asp Asp Met Asp Asp Phe 
145                 150                 155                 160 


Asp Xaa Ser Glu Xaa Ser Lys Ser Phe Val Xaa Pro Pro Gln Ser His 
                165                 170                 175     


Phe Val Arg Val Ser Xaa Ala Gln Lys Ser Lys Lys Gly Lys Arg Asn 
            180                 185                 190         


Phe Phe Lys Ala Gln Leu Tyr Xaa Xaa Asn Xaa Val Lys Xaa Asp Leu 
        195                 200                 205             


Pro Pro Pro Ser Ser Glu Ser Glu Gln Ile Asp Leu Xaa Glu Glu Gln 
    210                 215                 220                 


Lys Asp Asp Ser Glu Trp Leu Ser Ser Asp Val Ile Cys Ile Asp Asp 
225                 230                 235                 240 


Gly Pro Ile Ala Glu Val His Ile Asn Glu Asp Ala Gln Glu Ser Asp 
                245                 250                 255     


Ser Leu Lys Xaa His Leu Glu Asp Glu Arg Asp Asn Ser Glu Lys Lys 
            260                 265                 270         


Lys Asn Leu Glu Glu Ala Glu Leu His Ser Xaa Glu Lys Val Pro Cys 
        275                 280                 285             


Ile Glu Phe Asp Asp Asp Asp Tyr Asp Xaa Asp Phe Val Pro Pro Ser 
    290                 295                 300                 


Pro Glu Glu Ile Ile Ser Ala Ser Ser Ser Ser Ser Lys Cys Leu Ser 
305                 310                 315                 320 


Xaa Leu Lys Asp Leu Asp Xaa Ser Asp Arg Lys Glu Asp Val Leu Ser 
                325                 330                 335     


Xaa Ser Lys Asp Leu Leu Ser Lys Pro Glu Lys Met Ser Met Gln Glu 
            340                 345                 350         


Leu Asn Pro Glu Xaa Ser Xaa Asp Cys Asp Ala Arg Gln Ile Ser Leu 
        355                 360                 365             


Gln Gln Gln Leu Ile His Val Met Glu His Ile Cys Lys Leu Ile Asp 
    370                 375                 380                 


Xaa Ile Pro Asp Asp Lys Leu Lys Leu Leu Asp Cys Gly Asn Glu Leu 
385                 390                 395                 400 


Leu Gln Gln Arg Asn Ile Arg Arg Lys Leu Leu Xaa Glu Val Asp Phe 
                405                 410                 415     


Asn Lys Ser Asp Ala Ser Leu Leu Gly Ser Leu Trp Arg Tyr Arg Pro 
            420                 425                 430         


Asp Ser Leu Asp Gly Pro Met Glu Gly Asp Ser Cys Pro Xaa Gly Asn 
        435                 440                 445             


Ser Met Lys Glu Leu Asn Phe Ser His Leu Pro Ser Asn Ser Val Ser 
    450                 455                 460                 


Pro Gly Asp Cys Leu Leu Xaa Xaa Xaa Leu Gly Lys Xaa Gly Phe Ser 
465                 470                 475                 480 


Ala Xaa Arg Lys Asn Leu Phe Glu Arg Pro Leu Phe Asn Xaa His Leu 
                485                 490                 495     


Gln Lys Ser Phe Val Ser Ser Asn Trp Ala Glu Xaa Pro Arg Leu Gly 
            500                 505                 510         


Lys Lys Asn Glu Ser Ser Tyr Phe Pro Gly Asn Val Leu Xaa Ser Xaa 
        515                 520                 525             


Ala Val Lys Asp Gln Asn Lys His Xaa Ala Ser Ile Asn Asp Leu Glu 
    530                 535                 540                 


Arg Glu Xaa Gln Pro Ser Tyr Asp Ile Asp Asn Phe Asp Ile Asp Asp 
545                 550                 555                 560 


Phe Asp Asp Asp Asp Asp Trp Glu Asp Ile Met His Asn Leu Ala Ala 
                565                 570                 575     


Ser Lys Ser Ser Xaa Ala Ala Tyr Gln Pro Ile Lys Glu Gly Arg Pro 
            580                 585                 590         


Ile Lys Ser Val Ser Glu Arg Leu Ser Ser Ala Lys Xaa Asp Cys Leu 
        595                 600                 605             


Pro Val Ser Ser Xaa Ala Gln Asn Ile Asn Phe Ser Glu Ser Ile Gln 
    610                 615                 620                 


Asn Tyr Xaa Asp Lys Ser Ala Gln Asn Leu Ala Ser Arg Asn Leu Lys 
625                 630                 635                 640 


His Glu Arg Phe Gln Ser Leu Ser Phe Pro His Xaa Lys Glu Met Met 
                645                 650                 655     


Lys Ile Phe His Lys Lys Phe Gly Leu His Asn Phe Arg Xaa Asn Gln 
            660                 665                 670         


Leu Glu Ala Ile Asn Ala Ala Leu Leu Gly Glu Asp Cys Phe Ile Leu 
        675                 680                 685             


Met Pro Xaa Gly Gly Gly Lys Ser Leu Cys Tyr Gln Leu Pro Ala Cys 
    690                 695                 700                 


Val Ser Pro Gly Val Xaa Val Val Ile Ser Pro Leu Arg Ser Leu Ile 
705                 710                 715                 720 


Val Asp Gln Val Gln Lys Leu Xaa Ser Leu Asp Ile Pro Ala Xaa Tyr 
                725                 730                 735     


Leu Xaa Gly Asp Lys Xaa Asp Ser Glu Ala Xaa Asn Ile Tyr Leu Gln 
            740                 745                 750         


Leu Ser Lys Lys Asp Pro Ile Ile Lys Leu Leu Tyr Val Xaa Pro Glu 
        755                 760                 765             


Lys Ile Cys Ala Ser Asn Arg Leu Ile Ser Xaa Leu Glu Asn Leu Tyr 
    770                 775                 780                 


Glu Arg Lys Leu Leu Ala Arg Phe Val Ile Asp Glu Ala His Cys Val 
785                 790                 795                 800 


Ser Gln Trp Gly His Asp Phe Arg Gln Asp Tyr Lys Arg Met Asn Met 
                805                 810                 815     


Leu Arg Gln Lys Phe Pro Ser Val Pro Val Met Ala Leu Xaa Ala Xaa 
            820                 825                 830         


Ala Asn Pro Arg Val Gln Lys Asp Ile Leu Xaa Gln Leu Lys Ile Leu 
        835                 840                 845             


Arg Pro Gln Val Phe Ser Met Ser Phe Asn Arg His Asn Leu Lys Tyr 
    850                 855                 860                 


Tyr Val Leu Pro Lys Lys Pro Lys Lys Val Ala Phe Asp Cys Leu Glu 
865                 870                 875                 880 


Trp Ile Arg Lys His His Pro Tyr Asp Ser Gly Ile Ile Tyr Cys Leu 
                885                 890                 895     


Ser Arg Arg Glu Cys Asp Xaa Met Ala Asp Xaa Leu Gln Arg Asp Gly 
            900                 905                 910         


Leu Ala Ala Leu Ala Tyr His Ala Gly Leu Ser Asp Ser Ala Arg Asp 
        915                 920                 925             


Glu Val Gln Gln Lys Trp Ile Asn Gln Asp Gly Cys Gln Val Ile Cys 
    930                 935                 940                 


Ala Xaa Ile Ala Phe Gly Met Gly Ile Asp Lys Pro Asp Val Arg Phe 
945                 950                 955                 960 


Val Ile His Ala Ser Leu Pro Lys Ser Val Glu Gly Tyr Tyr Gln Glu 
                965                 970                 975     


Ser Gly Arg Ala Gly Arg Asp Gly Glu Ile Ser His Cys Leu Leu Phe 
            980                 985                 990         


Tyr Xaa Tyr His Asp Val Xaa Arg  Leu Lys Arg Leu Ile  Met Met Glu 
        995                 1000                 1005             


Lys Asp  Gly Asn His His Xaa  Arg Glu Xaa His Phe  Asn Asn Leu 
    1010                 1015                 1020             


Tyr Ser  Met Val His Tyr Cys  Glu Asn Ile Xaa Glu  Cys Arg Arg 
    1025                 1030                 1035             


Ile Gln  Leu Leu Ala Tyr Phe  Gly Glu Asn Gly Phe  Asn Pro Asp 
    1040                 1045                 1050             


Phe Cys  Lys Lys His Pro Asp  Val Ser Cys Asp Asn  Cys Cys Lys 
    1055                 1060                 1065             


Xaa Lys  Asp Tyr Lys Xaa Arg  Asp Val Xaa Asp Asp  Val Lys Ser 
    1070                 1075                 1080             


Ile Val  Arg Phe Val Gln Glu  His Ser Ser Ser Gln  Gly Met Arg 
    1085                 1090                 1095             


Asn Ile  Lys His Val Gly Pro  Ser Gly Arg Phe Xaa  Met Asn Met 
    1100                 1105                 1110             


Leu Val  Asp Ile Phe Leu Glu  Ser Leu Ser Ser Asp  Pro Glu Val 
    1115                 1120                 1125             


Leu Leu  Gln Ile Asp Gly Val  Xaa Glu Asp Lys Leu  Glu Lys Tyr 
    1130                 1135                 1140             


Gly Ala  Glu Val Ile Ser Val  Leu Gln Lys Tyr Ser  Glu Trp Xaa 
    1145                 1150                 1155             


Ser Pro  Ala Glu Asp Ser Ser  Pro Gly Ile Ser Leu  Ser Ser Ser 
    1160                 1165                 1170             


Arg Gly  Pro Gly Arg Ser Ala  Ala Glu Glu Leu Asp  Glu Glu Ile 
    1175                 1180                 1185             


Pro Val  Ser Ser His Tyr Phe  Ala Ser Lys Xaa Arg  Asn Glu Arg 
    1190                 1195                 1200             


Lys Arg  Lys Lys Met Pro Ala  Ser Gln Arg Ser Lys  Arg Arg Lys 
    1205                 1210                 1215             


Xaa Ala  Ser Ser Gly Ser Lys  Ala Lys Gly Gly Ser  Ala Xaa Cys 
    1220                 1225                 1230             


Arg Lys  Ile Ser Ser Lys Xaa  Lys Ser Ser Ser Ile  Ile Gly Ser 
    1235                 1240                 1245             


Ser Ser  Ala Ser His Xaa Ser  Gln Ala Xaa Ser Gly  Ala Asn Ser 
    1250                 1255                 1260             


Lys Leu  Gly Ile Met Ala Pro  Pro Lys Pro Ile Asn  Arg Pro Phe 
    1265                 1270                 1275             


Leu Lys  Pro Ser Tyr Ala Phe  Ser 
    1280                 1285     


<210> 4235
<211> 1417
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1179)..(1179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1243)..(1243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1245)..(1245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1267)..(1267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1330)..(1330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1363)..(1363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Selenocysteine

<400> 4235
Met Ala Ala Val Pro Gln Asn Asn Leu Gln Glu Gln Leu Glu Arg His 
1               5                   10                  15      


Ser Ala Arg Xaa Leu Asn Asn Lys Leu Ser Leu Ser Lys Pro Lys Phe 
            20                  25                  30          


Ser Gly Phe Xaa Phe Lys Lys Lys Xaa Ser Ser Asp Asn Asn Val Ser 
        35                  40                  45              


Val Xaa Asn Val Ser Val Ala Lys Xaa Pro Val Leu Arg Asn Lys Asp 
    50                  55                  60                  


Val Asn Val Xaa Glu Asp Phe Ser Phe Ser Glu Pro Leu Pro Asn Xaa 
65                  70                  75                  80  


Xaa Asn Gln Gln Arg Val Lys Asp Phe Phe Lys Asn Ala Pro Ala Gly 
                85                  90                  95      


Gln Glu Xaa Gln Arg Gly Gly Ser Lys Ser Leu Leu Pro Asp Phe Leu 
            100                 105                 110         


Gln Xaa Pro Lys Glu Val Val Cys Xaa Xaa Gln Asn Xaa Pro Xaa Val 
        115                 120                 125             


Lys Lys Ser Arg Asp Xaa Ala Leu Lys Lys Leu Glu Phe Ser Ser Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ser Xaa Ile Asn Asp Trp Asp Asp Met Asp Asp Phe 
145                 150                 155                 160 


Asp Xaa Ser Glu Xaa Ser Lys Ser Phe Val Xaa Pro Pro Gln Ser His 
                165                 170                 175     


Phe Val Arg Val Ser Xaa Ala Gln Lys Ser Lys Lys Gly Lys Arg Asn 
            180                 185                 190         


Phe Phe Lys Ala Gln Leu Tyr Xaa Xaa Asn Xaa Val Lys Xaa Asp Leu 
        195                 200                 205             


Pro Pro Pro Ser Ser Glu Ser Glu Gln Ile Asp Leu Xaa Glu Glu Gln 
    210                 215                 220                 


Lys Asp Asp Ser Glu Trp Leu Ser Ser Asp Val Ile Cys Ile Asp Asp 
225                 230                 235                 240 


Gly Pro Ile Ala Glu Val His Ile Asn Glu Asp Ala Gln Glu Ser Asp 
                245                 250                 255     


Ser Leu Lys Xaa His Leu Glu Asp Glu Arg Asp Asn Ser Glu Lys Lys 
            260                 265                 270         


Lys Asn Leu Glu Glu Ala Glu Leu His Ser Xaa Glu Lys Val Pro Cys 
        275                 280                 285             


Ile Glu Phe Asp Asp Asp Asp Tyr Asp Xaa Asp Phe Val Pro Pro Ser 
    290                 295                 300                 


Pro Glu Glu Ile Ile Ser Ala Ser Ser Ser Ser Ser Lys Cys Leu Ser 
305                 310                 315                 320 


Xaa Leu Lys Asp Leu Asp Xaa Ser Asp Arg Lys Glu Asp Val Leu Ser 
                325                 330                 335     


Xaa Ser Lys Asp Leu Leu Ser Lys Pro Glu Lys Met Ser Met Gln Glu 
            340                 345                 350         


Leu Asn Pro Glu Xaa Ser Xaa Asp Cys Asp Ala Arg Gln Ile Ser Leu 
        355                 360                 365             


Gln Gln Gln Leu Ile His Val Met Glu His Ile Cys Lys Leu Ile Asp 
    370                 375                 380                 


Xaa Ile Pro Asp Asp Lys Leu Lys Leu Leu Asp Cys Gly Asn Glu Leu 
385                 390                 395                 400 


Leu Gln Gln Arg Asn Ile Arg Arg Lys Leu Leu Xaa Glu Val Asp Phe 
                405                 410                 415     


Asn Lys Ser Asp Ala Ser Leu Leu Gly Ser Leu Trp Arg Tyr Arg Pro 
            420                 425                 430         


Asp Ser Leu Asp Gly Pro Met Glu Gly Asp Ser Cys Pro Xaa Gly Asn 
        435                 440                 445             


Ser Met Lys Glu Leu Asn Phe Ser His Leu Pro Ser Asn Ser Val Ser 
    450                 455                 460                 


Pro Gly Asp Cys Leu Leu Xaa Xaa Xaa Leu Gly Lys Xaa Gly Phe Ser 
465                 470                 475                 480 


Ala Xaa Arg Lys Asn Leu Phe Glu Arg Pro Leu Phe Asn Xaa His Leu 
                485                 490                 495     


Gln Lys Ser Phe Val Ser Ser Asn Trp Ala Glu Xaa Pro Arg Leu Gly 
            500                 505                 510         


Lys Lys Asn Glu Ser Ser Tyr Phe Pro Gly Asn Val Leu Xaa Ser Xaa 
        515                 520                 525             


Ala Val Lys Asp Gln Asn Lys His Xaa Ala Ser Ile Asn Asp Leu Glu 
    530                 535                 540                 


Arg Glu Xaa Gln Pro Ser Tyr Asp Ile Asp Asn Phe Asp Ile Asp Asp 
545                 550                 555                 560 


Phe Asp Asp Asp Asp Asp Trp Glu Asp Ile Met His Asn Leu Ala Ala 
                565                 570                 575     


Ser Lys Ser Ser Xaa Ala Ala Tyr Gln Pro Ile Lys Glu Gly Arg Pro 
            580                 585                 590         


Ile Lys Ser Val Ser Glu Arg Leu Ser Ser Ala Lys Xaa Asp Cys Leu 
        595                 600                 605             


Pro Val Ser Ser Xaa Ala Gln Asn Ile Asn Phe Ser Glu Ser Ile Gln 
    610                 615                 620                 


Asn Tyr Xaa Asp Lys Ser Ala Gln Asn Leu Ala Ser Arg Asn Leu Lys 
625                 630                 635                 640 


His Glu Arg Phe Gln Ser Leu Ser Phe Pro His Xaa Lys Glu Met Met 
                645                 650                 655     


Lys Ile Phe His Lys Lys Phe Gly Leu His Asn Phe Arg Xaa Asn Gln 
            660                 665                 670         


Leu Glu Ala Ile Asn Ala Ala Leu Leu Gly Glu Asp Cys Phe Ile Leu 
        675                 680                 685             


Met Pro Xaa Gly Gly Gly Lys Ser Leu Cys Tyr Gln Leu Pro Ala Cys 
    690                 695                 700                 


Val Ser Pro Gly Val Xaa Val Val Ile Ser Pro Leu Arg Ser Leu Ile 
705                 710                 715                 720 


Val Asp Gln Val Gln Lys Leu Xaa Ser Leu Asp Ile Pro Ala Xaa Tyr 
                725                 730                 735     


Leu Xaa Gly Asp Lys Xaa Asp Ser Glu Ala Xaa Asn Ile Tyr Leu Gln 
            740                 745                 750         


Leu Ser Lys Lys Asp Pro Ile Ile Lys Leu Leu Tyr Val Xaa Pro Glu 
        755                 760                 765             


Lys Ile Cys Ala Ser Asn Arg Leu Ile Ser Xaa Leu Glu Asn Leu Tyr 
    770                 775                 780                 


Glu Arg Lys Leu Leu Ala Arg Phe Val Ile Asp Glu Ala His Cys Val 
785                 790                 795                 800 


Ser Gln Trp Gly His Asp Phe Arg Gln Asp Tyr Lys Arg Met Asn Met 
                805                 810                 815     


Leu Arg Gln Lys Phe Pro Ser Val Pro Val Met Ala Leu Xaa Ala Xaa 
            820                 825                 830         


Ala Asn Pro Arg Val Gln Lys Asp Ile Leu Xaa Gln Leu Lys Ile Leu 
        835                 840                 845             


Arg Pro Gln Val Phe Ser Met Ser Phe Asn Arg His Asn Leu Lys Tyr 
    850                 855                 860                 


Tyr Val Leu Pro Lys Lys Pro Lys Lys Val Ala Phe Asp Cys Leu Glu 
865                 870                 875                 880 


Trp Ile Arg Lys His His Pro Tyr Asp Ser Gly Ile Ile Tyr Cys Leu 
                885                 890                 895     


Ser Arg Arg Glu Cys Asp Xaa Met Ala Asp Xaa Leu Gln Arg Asp Gly 
            900                 905                 910         


Leu Ala Ala Leu Ala Tyr His Ala Gly Leu Ser Asp Ser Ala Arg Asp 
        915                 920                 925             


Glu Val Gln Gln Lys Trp Ile Asn Gln Asp Gly Cys Gln Val Ile Cys 
    930                 935                 940                 


Ala Xaa Ile Ala Phe Gly Met Gly Ile Asp Lys Pro Asp Val Arg Phe 
945                 950                 955                 960 


Val Ile His Ala Ser Leu Pro Lys Ser Val Glu Gly Tyr Tyr Gln Glu 
                965                 970                 975     


Ser Gly Arg Ala Gly Arg Asp Gly Glu Ile Ser His Cys Leu Leu Phe 
            980                 985                 990         


Tyr Xaa Tyr His Asp Val Xaa Arg  Leu Lys Arg Leu Ile  Met Met Glu 
        995                 1000                 1005             


Lys Asp  Gly Asn His His Xaa  Arg Glu Xaa His Phe  Asn Asn Leu 
    1010                 1015                 1020             


Tyr Ser  Met Val His Tyr Cys  Glu Asn Ile Xaa Glu  Cys Arg Arg 
    1025                 1030                 1035             


Ile Gln  Leu Leu Ala Tyr Phe  Gly Glu Asn Gly Phe  Asn Pro Asp 
    1040                 1045                 1050             


Phe Cys  Lys Lys His Pro Asp  Val Ser Cys Asp Asn  Cys Cys Lys 
    1055                 1060                 1065             


Xaa Lys  Asp Tyr Lys Xaa Arg  Asp Val Xaa Asp Asp  Val Lys Ser 
    1070                 1075                 1080             


Ile Val  Arg Phe Val Gln Glu  His Ser Ser Ser Gln  Gly Met Arg 
    1085                 1090                 1095             


Asn Ile  Lys His Val Gly Pro  Ser Gly Arg Phe Xaa  Met Asn Met 
    1100                 1105                 1110             


Leu Val  Asp Ile Phe Leu Gly  Ser Lys Ser Ala Lys  Ile Gln Ser 
    1115                 1120                 1125             


Gly Ile  Phe Gly Lys Gly Ser  Ala Tyr Ser Arg His  Asn Ala Glu 
    1130                 1135                 1140             


Arg Leu  Phe Lys Lys Leu Ile  Leu Asp Lys Ile Leu  Asp Glu Asp 
    1145                 1150                 1155             


Leu Tyr  Ile Asn Ala Asn Asp  Gln Ala Ile Ala Tyr  Val Met Leu 
    1160                 1165                 1170             


Gly Asn  Lys Ala Gln Xaa Val  Leu Asn Gly Asn Leu  Lys Val Asp 
    1175                 1180                 1185             


Phe Met  Glu Xaa Glu Asn Ser  Ser Ser Val Lys Lys  Gln Lys Ala 
    1190                 1195                 1200             


Leu Val  Ala Lys Val Ser Gln  Arg Glu Glu Met Val  Lys Lys Cys 
    1205                 1210                 1215             


Leu Gly  Glu Leu Xaa Glu Val  Cys Lys Ser Leu Gly  Lys Val Phe 
    1220                 1225                 1230             


Gly Val  His Tyr Phe Asn Ile  Phe Asn Xaa Val Xaa  Leu Lys Lys 
    1235                 1240                 1245             


Leu Ala  Glu Ser Leu Ser Ser  Asp Pro Glu Val Leu  Leu Gln Ile 
    1250                 1255                 1260             


Asp Gly  Val Xaa Glu Asp Lys  Leu Glu Lys Tyr Gly  Ala Glu Val 
    1265                 1270                 1275             


Ile Ser  Val Leu Gln Lys Tyr  Ser Glu Trp Xaa Ser  Pro Ala Glu 
    1280                 1285                 1290             


Asp Ser  Ser Pro Gly Ile Ser  Leu Ser Ser Ser Arg  Gly Pro Gly 
    1295                 1300                 1305             


Arg Ser  Ala Ala Glu Glu Leu  Asp Glu Glu Ile Pro  Val Ser Ser 
    1310                 1315                 1320             


His Tyr  Phe Ala Ser Lys Xaa  Arg Asn Glu Arg Lys  Arg Lys Lys 
    1325                 1330                 1335             


Met Pro  Ala Ser Gln Arg Ser  Lys Arg Arg Lys Xaa  Ala Ser Ser 
    1340                 1345                 1350             


Gly Ser  Lys Ala Lys Gly Gly  Ser Ala Xaa Cys Arg  Lys Ile Ser 
    1355                 1360                 1365             


Ser Lys  Xaa Lys Ser Ser Ser  Ile Ile Gly Ser Ser  Ser Ala Ser 
    1370                 1375                 1380             


His Xaa  Ser Gln Ala Xaa Ser  Gly Ala Asn Ser Lys  Leu Gly Ile 
    1385                 1390                 1395             


Met Ala  Pro Pro Lys Pro Ile  Asn Arg Pro Phe Leu  Lys Pro Ser 
    1400                 1405                 1410             


Tyr Ala  Phe Ser 
    1415         


<210> 4236
<211> 65
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<400> 4236
Met Asp Lys Leu Asn Lys Ile Xaa Val Pro Ala Ser Gln Lys Leu Arg 
1               5                   10                  15      


Gln Leu Gln Lys Met Val His Asp Ile Lys Asn Asn Glu Gly Gly Ile 
            20                  25                  30          


Met Asn Lys Ile Lys Lys Leu Lys Val Lys Ala Pro Pro Ser Val Pro 
        35                  40                  45              


Arg Arg Asp Tyr Ala Ser Asp Xaa Cys Ser Leu Ser Trp Asn Pro Ser 
    50                  55                  60                  


Lys 
65  


<210> 4237
<211> 404
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<400> 4237
Met Asp Lys Leu Asn Lys Ile Xaa Val Pro Ala Ser Gln Lys Leu Arg 
1               5                   10                  15      


Gln Leu Gln Lys Met Val His Asp Ile Lys Asn Asn Glu Gly Gly Ile 
            20                  25                  30          


Met Asn Lys Ile Lys Lys Leu Lys Val Lys Ala Pro Pro Ser Val Pro 
        35                  40                  45              


Arg Arg Asp Tyr Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp 
    50                  55                  60                  


Ser Asp Asp Phe Asp Ser Asp Tyr Glu Asn Pro Asp Glu His Ser Asp 
65                  70                  75                  80  


Ser Glu Met Tyr Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Tyr 
                85                  90                  95      


Glu Pro Pro Pro Val Glu Gln Glu Xaa Arg Pro Val His Pro Ala Leu 
            100                 105                 110         


Pro Phe Ala Arg Gly Glu Tyr Ile Asp Asn Arg Ser Ser Gln Arg His 
        115                 120                 125             


Ser Pro Pro Phe Ser Lys Xaa Leu Pro Ser Lys Pro Ser Trp Pro Ser 
    130                 135                 140                 


Glu Lys Ala Arg Leu Xaa Ser Xaa Leu Pro Ala Leu Xaa Ala Leu Gln 
145                 150                 155                 160 


Lys Pro Gln Val Pro Pro Lys Pro Lys Gly Leu Leu Glu Asp Glu Ala 
                165                 170                 175     


Asp Tyr Val Val Pro Val Glu Asp Asn Asp Glu Asn Tyr Ile His Pro 
            180                 185                 190         


Xaa Glu Ser Ser Ser Pro Pro Pro Glu Lys Ala Pro Met Val Asn Arg 
        195                 200                 205             


Ser Xaa Lys Pro Asn Ser Ser Xaa Pro Ala Ser Pro Pro Gly Xaa Ala 
    210                 215                 220                 


Ser Gly Arg Asn Ser Gly Ala Trp Glu Xaa Lys Ser Pro Pro Pro Ala 
225                 230                 235                 240 


Ala Pro Ser Pro Leu Pro Arg Ala Gly Lys Lys Pro Xaa Xaa Pro Leu 
                245                 250                 255     


Lys Xaa Xaa Pro Val Ala Ser Gln Gln Asn Ala Ser Ser Val Cys Glu 
            260                 265                 270         


Glu Lys Pro Ile Pro Ala Glu Arg His Arg Gly Ser Ser His Arg Gln 
        275                 280                 285             


Glu Ala Val Gln Ser Pro Val Phe Pro Pro Ala Gln Lys Gln Ile His 
    290                 295                 300                 


Gln Lys Pro Ile Pro Leu Pro Arg Phe Xaa Glu Gly Gly Asn Pro Xaa 
305                 310                 315                 320 


Val Asp Gly Pro Leu Pro Ser Phe Ser Ser Asn Ser Xaa Ile Ser Glu 
                325                 330                 335     


Gln Glu Ala Gly Val Leu Cys Lys Pro Trp Tyr Ala Gly Ala Cys Asp 
            340                 345                 350         


Arg Lys Ser Ala Glu Glu Ala Leu His Arg Ser Asn Lys Tyr Phe Gly 
        355                 360                 365             


Ser Val Ala Glu Ile Ile Arg Asn His Gln His Ser Pro Leu Val Leu 
    370                 375                 380                 


Ile Asp Ser Gln Asn Asn Xaa Lys Asp Ser Xaa Arg Leu Lys Tyr Ala 
385                 390                 395                 400 


Val Lys Val Ser 
                


<210> 4238
<211> 456
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<400> 4238
Met Asp Lys Leu Asn Lys Ile Xaa Val Pro Ala Ser Gln Lys Leu Arg 
1               5                   10                  15      


Gln Leu Gln Lys Met Val His Asp Ile Lys Asn Asn Glu Gly Gly Ile 
            20                  25                  30          


Met Asn Lys Ile Lys Lys Leu Lys Val Lys Ala Pro Pro Ser Val Pro 
        35                  40                  45              


Arg Arg Asp Tyr Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp 
    50                  55                  60                  


Ser Asp Asp Phe Asp Ser Asp Tyr Glu Asn Pro Asp Glu His Ser Asp 
65                  70                  75                  80  


Ser Glu Met Tyr Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Tyr 
                85                  90                  95      


Glu Pro Pro Pro Val Glu Gln Glu Xaa Arg Pro Val His Pro Ala Leu 
            100                 105                 110         


Pro Phe Ala Arg Gly Glu Tyr Ile Asp Asn Arg Ser Ser Gln Arg His 
        115                 120                 125             


Ser Pro Pro Phe Ser Lys Xaa Leu Pro Ser Lys Pro Ser Trp Pro Ser 
    130                 135                 140                 


Glu Lys Ala Arg Leu Xaa Ser Xaa Leu Pro Ala Leu Xaa Ala Leu Gln 
145                 150                 155                 160 


Lys Pro Gln Val Pro Pro Lys Pro Lys Gly Leu Leu Glu Asp Glu Ala 
                165                 170                 175     


Asp Tyr Val Val Pro Val Glu Asp Asn Asp Glu Asn Tyr Ile His Pro 
            180                 185                 190         


Xaa Glu Ser Ser Ser Pro Pro Pro Glu Lys Ala Pro Met Val Asn Arg 
        195                 200                 205             


Ser Xaa Lys Pro Asn Ser Ser Xaa Pro Ala Ser Pro Pro Gly Xaa Ala 
    210                 215                 220                 


Ser Gly Arg Asn Ser Gly Ala Trp Glu Xaa Lys Ser Pro Pro Pro Ala 
225                 230                 235                 240 


Ala Pro Ser Pro Leu Pro Arg Ala Gly Lys Lys Pro Xaa Xaa Pro Leu 
                245                 250                 255     


Lys Xaa Xaa Pro Val Ala Ser Gln Gln Asn Ala Ser Ser Val Cys Glu 
            260                 265                 270         


Glu Lys Pro Ile Pro Ala Glu Arg His Arg Gly Ser Ser His Arg Gln 
        275                 280                 285             


Glu Ala Val Gln Ser Pro Val Phe Pro Pro Ala Gln Lys Gln Ile His 
    290                 295                 300                 


Gln Lys Pro Ile Pro Leu Pro Arg Phe Xaa Glu Gly Gly Asn Pro Xaa 
305                 310                 315                 320 


Val Asp Gly Pro Leu Pro Ser Phe Ser Ser Asn Ser Xaa Ile Ser Glu 
                325                 330                 335     


Gln Glu Ala Gly Val Leu Cys Lys Pro Trp Tyr Ala Gly Ala Cys Asp 
            340                 345                 350         


Arg Lys Ser Ala Glu Glu Ala Leu His Arg Ser Asn Lys Asp Gly Ser 
        355                 360                 365             


Phe Leu Ile Arg Lys Ser Ser Gly His Asp Ser Lys Gln Pro Tyr Xaa 
    370                 375                 380                 


Leu Val Val Phe Phe Asn Lys Arg Val Tyr Asn Ile Pro Val Arg Phe 
385                 390                 395                 400 


Ile Glu Ala Xaa Lys Gln Tyr Ala Leu Gly Arg Lys Lys Asn Gly Glu 
                405                 410                 415     


Glu Tyr Phe Gly Ser Val Ala Glu Ile Ile Arg Asn His Gln His Ser 
            420                 425                 430         


Pro Leu Val Leu Ile Asp Ser Gln Asn Asn Xaa Lys Asp Ser Xaa Arg 
        435                 440                 445             


Leu Lys Tyr Ala Val Lys Val Ser 
    450                 455     


<210> 4239
<211> 433
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<400> 4239
Met Asp Lys Leu Asn Lys Ile Xaa Val Pro Ala Ser Gln Lys Leu Arg 
1               5                   10                  15      


Gln Leu Gln Lys Met Val His Asp Ile Lys Asn Asn Glu Gly Gly Ile 
            20                  25                  30          


Met Asn Lys Ile Lys Lys Leu Lys Val Lys Ala Pro Pro Ser Val Pro 
        35                  40                  45              


Arg Arg Asp Tyr Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp 
    50                  55                  60                  


Ser Asp Asp Phe Asp Ser Asp Tyr Glu Asn Pro Asp Glu His Ser Asp 
65                  70                  75                  80  


Ser Glu Met Tyr Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Tyr 
                85                  90                  95      


Glu Pro Pro Pro Val Glu Gln Glu Xaa Arg Pro Val His Pro Ala Leu 
            100                 105                 110         


Pro Phe Ala Arg Gly Glu Tyr Ile Asp Asn Arg Ser Ser Gln Arg His 
        115                 120                 125             


Ser Pro Pro Phe Ser Lys Xaa Leu Pro Ser Lys Pro Ser Trp Pro Ser 
    130                 135                 140                 


Glu Lys Ala Arg Leu Xaa Ser Xaa Leu Pro Ala Leu Xaa Ala Leu Gln 
145                 150                 155                 160 


Lys Pro Gln Val Pro Pro Lys Pro Lys Gly Leu Leu Glu Asp Glu Ala 
                165                 170                 175     


Asp Tyr Val Val Pro Val Glu Asp Asn Asp Glu Asn Tyr Ile His Pro 
            180                 185                 190         


Xaa Glu Ser Ser Ser Pro Pro Pro Glu Lys Gly Arg Asn Ser Gly Ala 
        195                 200                 205             


Trp Glu Xaa Lys Ser Pro Pro Pro Ala Ala Pro Ser Pro Leu Pro Arg 
    210                 215                 220                 


Ala Gly Lys Lys Pro Xaa Xaa Pro Leu Lys Xaa Xaa Pro Val Ala Ser 
225                 230                 235                 240 


Gln Gln Asn Ala Ser Ser Val Cys Glu Glu Lys Pro Ile Pro Ala Glu 
                245                 250                 255     


Arg His Arg Gly Ser Ser His Arg Gln Glu Ala Val Gln Ser Pro Val 
            260                 265                 270         


Phe Pro Pro Ala Gln Lys Gln Ile His Gln Lys Pro Ile Pro Leu Pro 
        275                 280                 285             


Arg Phe Xaa Glu Gly Gly Asn Pro Xaa Val Asp Gly Pro Leu Pro Ser 
    290                 295                 300                 


Phe Ser Ser Asn Ser Xaa Ile Ser Glu Gln Glu Ala Gly Val Leu Cys 
305                 310                 315                 320 


Lys Pro Trp Tyr Ala Gly Ala Cys Asp Arg Lys Ser Ala Glu Glu Ala 
                325                 330                 335     


Leu His Arg Ser Asn Lys Asp Gly Ser Phe Leu Ile Arg Lys Ser Ser 
            340                 345                 350         


Gly His Asp Ser Lys Gln Pro Tyr Xaa Leu Val Val Phe Phe Asn Lys 
        355                 360                 365             


Arg Val Tyr Asn Ile Pro Val Arg Phe Ile Glu Ala Xaa Lys Gln Tyr 
    370                 375                 380                 


Ala Leu Gly Arg Lys Lys Asn Gly Glu Glu Tyr Phe Gly Ser Val Ala 
385                 390                 395                 400 


Glu Ile Ile Arg Asn His Gln His Ser Pro Leu Val Leu Ile Asp Ser 
                405                 410                 415     


Gln Asn Asn Xaa Lys Asp Ser Xaa Arg Leu Lys Tyr Ala Val Lys Val 
            420                 425                 430         


Ser 
    


<210> 4240
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<400> 4240
Met Asp Lys Leu Asn Lys Ile Xaa Val Pro Ala Ser Gln Lys Leu Arg 
1               5                   10                  15      


Gln Leu Gln Lys Met Val His Asp Ile Lys Asn Asn Glu Gly Gly Ile 
            20                  25                  30          


Met Asn Lys Ile Lys Lys Leu Lys Val Lys Ala Pro Pro Ser Val Pro 
        35                  40                  45              


Arg Arg Asp Tyr Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp 
    50                  55                  60                  


Ser Asp Asp Phe Asp Ser Asp Tyr Glu Asn Pro Asp Glu His Ser Asp 
65                  70                  75                  80  


Ser Glu Met Tyr Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Tyr 
                85                  90                  95      


Glu Pro Pro Pro Val Glu Gln Glu Xaa Arg Pro Val His Pro Ala Leu 
            100                 105                 110         


Pro Phe Ala Arg Gly Glu Tyr Ile Gly 
        115                 120     


<210> 4241
<211> 299
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<400> 4241
Met Asp Lys Leu Asn Lys Ile Xaa Val Pro Ala Ser Gln Lys Leu Arg 
1               5                   10                  15      


Gln Leu Gln Lys Met Val His Asp Ile Lys Asn Asn Glu Gly Gly Ile 
            20                  25                  30          


Met Asn Lys Ile Lys Lys Leu Lys Val Lys Ala Pro Pro Ser Val Pro 
        35                  40                  45              


Arg Arg Asp Tyr Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp 
    50                  55                  60                  


Ser Asp Asp Phe Asp Ser Asp Tyr Glu Asn Pro Asp Glu His Ser Asp 
65                  70                  75                  80  


Ser Glu Met Tyr Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Tyr 
                85                  90                  95      


Glu Pro Pro Pro Val Glu Gln Glu Xaa Arg Pro Val His Pro Ala Leu 
            100                 105                 110         


Pro Phe Ala Arg Gly Xaa Ala Ser Gly Arg Asn Ser Gly Ala Trp Glu 
        115                 120                 125             


Xaa Lys Ser Pro Pro Pro Ala Ala Pro Ser Pro Leu Pro Arg Ala Gly 
    130                 135                 140                 


Lys Lys Pro Xaa Xaa Pro Leu Lys Xaa Xaa Pro Val Ala Ser Gln Gln 
145                 150                 155                 160 


Asn Ala Ser Ser Val Cys Glu Glu Lys Pro Ile Pro Ala Glu Arg His 
                165                 170                 175     


Arg Gly Ser Ser His Arg Gln Glu Ala Val Gln Ser Pro Val Phe Pro 
            180                 185                 190         


Pro Ala Gln Lys Gln Ile His Gln Lys Pro Ile Pro Leu Pro Arg Phe 
        195                 200                 205             


Xaa Glu Gly Gly Asn Pro Xaa Val Asp Gly Pro Leu Pro Ser Phe Ser 
    210                 215                 220                 


Ser Asn Ser Xaa Ile Ser Glu Gln Glu Ala Gly Val Leu Cys Lys Pro 
225                 230                 235                 240 


Trp Tyr Ala Gly Ala Cys Asp Arg Lys Ser Ala Glu Glu Ala Leu His 
                245                 250                 255     


Arg Ser Asn Lys Tyr Phe Gly Ser Val Ala Glu Ile Ile Arg Asn His 
            260                 265                 270         


Gln His Ser Pro Leu Val Leu Ile Asp Ser Gln Asn Asn Xaa Lys Asp 
        275                 280                 285             


Ser Xaa Arg Leu Lys Tyr Ala Val Lys Val Ser 
    290                 295                 


<210> 4242
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<400> 4242
Cys Arg Asp Met Phe Ser Lys Met Ala Xaa Tyr Leu Xaa Gly Glu Leu 
1               5                   10                  15      


Xaa Ala Xaa Ser Glu Asp Tyr Lys Leu Leu Glu Asn Met Asn Lys Leu 
            20                  25                  30          


Xaa Ser Leu Lys Tyr Leu Glu Met Lys Asp Ile Ala Ile Asn Ile Ser 
        35                  40                  45              


Arg Asn Leu Lys Asp Leu Asn Gln Lys Tyr Ala Gly Leu Gln Pro Tyr 
    50                  55                  60                  


Leu Asp Gln Ile Asn Val Ile Glu Glu Gln Val Ala Ala Leu Glu Gln 
65                  70                  75                  80  


Ala Ala Tyr Lys Leu Asp Ala Tyr Ser Lys Lys Leu Gly Asn Arg Phe 
                85                  90                  95      


Tyr Phe Cys Phe Asp Val Ile Lys Xaa Ala Ser Cys Gln His Ile Leu 
            100                 105                 110         


Ser Lys His Asn Ser 
        115         


<210> 4243
<211> 142
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<400> 4243
Met Ala Ala Ala Ala Glu Gly Val Leu Ala Xaa Arg Ser Asp Glu Pro 
1               5                   10                  15      


Ala Arg Asp Asp Ala Ala Val Glu Xaa Ala Glu Glu Ala Lys Glu Pro 
            20                  25                  30          


Ala Glu Ala Asp Ile Xaa Glu Leu Cys Arg Asp Met Phe Ser Lys Met 
        35                  40                  45              


Ala Xaa Tyr Leu Xaa Gly Glu Leu Xaa Ala Xaa Ser Glu Asp Tyr Lys 
    50                  55                  60                  


Leu Leu Glu Asn Met Asn Lys Leu Xaa Ser Leu Lys Tyr Leu Glu Met 
65                  70                  75                  80  


Lys Asp Ile Ala Ile Asn Ile Ser Arg Asn Leu Lys Asp Leu Asn Gln 
                85                  90                  95      


Lys Tyr Ala Gly Leu Gln Pro Tyr Leu Asp Gln Ile Asn Val Ile Glu 
            100                 105                 110         


Glu Gln Val Ala Ala Leu Glu Gln Ala Ala Tyr Lys Leu Asp Ala Tyr 
        115                 120                 125             


Ser Lys Lys Leu Glu Ala Lys Tyr Lys Lys Leu Glu Lys Arg 
    130                 135                 140         


<210> 4244
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<400> 4244
Met Phe Ser Lys Met Ala Xaa Tyr Leu Xaa Gly Glu Leu Xaa Ala Xaa 
1               5                   10                  15      


Ser Glu Asp Tyr Lys Leu Leu Glu Asn Met Asn Lys Leu Xaa Ser Leu 
            20                  25                  30          


Lys Tyr Leu Glu Met Lys Asp Ile Ala Ile Asn Ile Ser Arg Asn Leu 
        35                  40                  45              


Lys Asp Leu Asn Gln Lys Tyr Ala Gly Leu Gln Pro Tyr Leu Asp Gln 
    50                  55                  60                  


Ile Asn Val Ile Glu Glu Gln Val Ala Ala Leu Glu Gln Ala Ala Tyr 
65                  70                  75                  80  


Lys Leu Asp Ala Tyr Ser Lys Lys Leu Glu Ala Lys Tyr Lys Lys Leu 
                85                  90                  95      


Glu Lys Arg 
            


<210> 4245
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<400> 4245
Met Arg Leu Pro Arg Lys Ser Leu Glu Val Ala Xaa Ser Glu Asp Tyr 
1               5                   10                  15      


Lys Leu Leu Glu Asn Met Asn Lys Leu Xaa Ser Leu Lys Tyr Leu Glu 
            20                  25                  30          


Met Lys Asp Ile Ala Ile Asn Ile Ser Arg Asn Leu Lys Asp Leu Asn 
        35                  40                  45              


Gln Lys Tyr Ala Gly Leu Gln Pro Tyr Leu Asp Gln Ile Asn Val Ile 
    50                  55                  60                  


Glu Glu Gln Val Ala Ala Leu Glu Gln Ala Ala Tyr Lys Leu Asp Ala 
65                  70                  75                  80  


Tyr Ser Lys Lys Leu Glu Ala Lys Tyr Lys Lys Leu Glu Lys Arg 
                85                  90                  95  


<210> 4246
<211> 127
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<400> 4246
Met Xaa Xaa Lys Asn Leu Glu Xaa Lys Val Xaa Val Xaa Ser Ser Pro 
1               5                   10                  15      


Ile Arg Gly Ala Gly Asp Gly Met Glu Xaa Glu Glu Pro Pro Lys Ser 
            20                  25                  30          


Val Glu Val Xaa Ser Gly Val Gln Ser Arg Lys His His Ser Leu Gln 
        35                  40                  45              


Ser Pro Trp Lys Lys Ala Val Pro Ser Glu Ser Pro Gly Val Leu Gln 
    50                  55                  60                  


Leu Gly Lys Met Leu Xaa Glu Lys Ala Met Glu Val Lys Ala Val Arg 
65                  70                  75                  80  


Ile Leu Val Pro Lys Ala Ala Ile Xaa His Asp Ile Pro Asn Lys Asn 
                85                  90                  95      


Xaa Lys Val Lys Ser Leu Gly His His Lys Gly Glu Phe Leu Gly Gln 
            100                 105                 110         


Ser Glu Gly Val Ile Glu Pro Asn Lys Glu Leu Ser Glu Val Lys 
        115                 120                 125         


<210> 4247
<211> 250
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<400> 4247
Met Xaa Xaa Lys Asn Leu Glu Xaa Lys Val Xaa Val Xaa Ser Ser Pro 
1               5                   10                  15      


Ile Arg Gly Ala Gly Asp Gly Met Glu Xaa Glu Glu Pro Pro Lys Ser 
            20                  25                  30          


Val Glu Val Xaa Ser Gly Val Gln Ser Arg Lys His His Ser Leu Gln 
        35                  40                  45              


Ser Pro Trp Lys Lys Ala Val Pro Ser Glu Ser Pro Gly Val Leu Gln 
    50                  55                  60                  


Leu Gly Lys Met Leu Xaa Glu Lys Ala Met Glu Val Lys Ala Val Arg 
65                  70                  75                  80  


Ile Leu Val Pro Lys Ala Ala Ile Xaa His Asp Ile Pro Asn Lys Asn 
                85                  90                  95      


Xaa Lys Val Lys Ser Leu Gly His His Lys Gly Glu Phe Leu Gly Gln 
            100                 105                 110         


Ser Glu Gly Val Ile Glu Pro Asn Lys Glu Leu Ser Glu Val Lys Asn 
        115                 120                 125             


Val Leu Glu Lys Leu Lys Asn Ser Glu Arg Arg Leu Leu Gln Asp Lys 
    130                 135                 140                 


Glu Gly Leu Ser Asn Gln Leu Arg Val Gln Xaa Glu Val Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Leu Leu Val Ala Ser Val Gly Asp Asp Leu Gln Tyr His 
                165                 170                 175     


Phe Glu Arg Leu Ala Arg Glu Lys Asn Gln Leu Ile Leu Glu Asn Glu 
            180                 185                 190         


Ala Leu Gly Arg Asn Xaa Ala Gln Leu Ser Glu Gln Leu Glu Arg Met 
        195                 200                 205             


Ser Ile Gln Cys Asp Val Trp Arg Ser Lys Phe Leu Ala Ser Arg Val 
    210                 215                 220                 


Met Ala Asp Glu Leu Xaa Asn Ser Arg Ala Ala Leu Gln Arg Gln Asn 
225                 230                 235                 240 


Arg Asp Ala His Gly Ala Ile Gln Asp Leu 
                245                 250 


<210> 4248
<211> 400
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<400> 4248
Met Xaa Xaa Lys Asn Leu Glu Xaa Lys Val Xaa Val Xaa Ser Ser Pro 
1               5                   10                  15      


Ile Arg Gly Ala Gly Asp Gly Met Glu Xaa Glu Glu Pro Pro Lys Ser 
            20                  25                  30          


Val Glu Val Xaa Ser Gly Val Gln Ser Arg Lys His His Ser Leu Gln 
        35                  40                  45              


Ser Pro Trp Lys Lys Ala Val Pro Ser Glu Ser Pro Gly Val Leu Gln 
    50                  55                  60                  


Leu Gly Lys Met Leu Xaa Glu Lys Ala Met Glu Val Lys Ala Val Arg 
65                  70                  75                  80  


Ile Leu Val Pro Lys Ala Ala Ile Xaa His Asp Ile Pro Asn Lys Asn 
                85                  90                  95      


Xaa Lys Val Lys Ser Leu Gly His His Lys Gly Glu Phe Leu Gly Gln 
            100                 105                 110         


Ser Glu Gly Val Ile Glu Pro Asn Lys Glu Leu Ser Glu Val Lys Asn 
        115                 120                 125             


Val Leu Glu Lys Leu Lys Asn Ser Glu Arg Arg Leu Leu Gln Asp Lys 
    130                 135                 140                 


Glu Gly Leu Ser Asn Gln Leu Arg Val Gln Xaa Glu Val Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Leu Leu Val Ala Ser Val Gly Asp Asp Leu Gln Tyr His 
                165                 170                 175     


Phe Glu Arg Leu Ala Arg Glu Lys Asn Gln Leu Ile Leu Glu Asn Glu 
            180                 185                 190         


Ala Leu Gly Arg Asn Xaa Ala Gln Leu Ser Glu Gln Leu Glu Arg Met 
        195                 200                 205             


Ser Ile Gln Cys Asp Val Trp Arg Ser Lys Phe Leu Ala Ser Arg Val 
    210                 215                 220                 


Met Ala Asp Glu Leu Xaa Asn Ser Arg Ala Ala Leu Gln Arg Gln Asn 
225                 230                 235                 240 


Arg Asp Ala His Gly Ala Ile Gln Asp Leu Leu Ser Glu Arg Glu Gln 
                245                 250                 255     


Phe Arg Gln Glu Met Ile Ala Xaa Gln Lys Leu Leu Glu Glu Leu Leu 
            260                 265                 270         


Val Ser Leu Gln Trp Gly Arg Glu Gln Xaa Tyr Ser Pro Ser Val Gln 
        275                 280                 285             


Pro His Ser Xaa Ala Glu Leu Ala Leu Xaa Asn His Lys Leu Ala Lys 
    290                 295                 300                 


Ala Val Asn Ser His Leu Leu Gly Asn Val Gly Ile Asn Asn Gln Lys 
305                 310                 315                 320 


Lys Ile Pro Ser Xaa Val Glu Phe Cys Ser Xaa Pro Ala Glu Lys Met 
                325                 330                 335     


Ala Glu Xaa Val Leu Arg Ile Leu Asp Pro Val Xaa Cys Lys Glu Ser 
            340                 345                 350         


Ser Pro Asp Asn Pro Phe Phe Glu Ser Ser Pro Xaa Xaa Leu Leu Ala 
        355                 360                 365             


Xaa Lys Lys Asn Ile Gly Arg Phe His Pro Tyr Xaa Arg Tyr Glu Asn 
    370                 375                 380                 


Ile Xaa Phe Asn Cys Cys Asn His Cys Arg Gly Glu Leu Ile Ala Leu 
385                 390                 395                 400 


<210> 4249
<211> 174
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 4249
Met Xaa Xaa Lys Asn Leu Glu Xaa Lys Val Xaa Val Xaa Ser Ser Pro 
1               5                   10                  15      


Ile Arg Gly Ala Gly Asp Gly Met Glu Xaa Glu Glu Pro Pro Lys Ser 
            20                  25                  30          


Val Glu Val Xaa Ser Gly Val Gln Ser Arg Lys His His Ser Leu Gln 
        35                  40                  45              


Ser Pro Trp Lys Lys Ala Val Pro Ser Glu Ser Pro Gly Val Leu Gln 
    50                  55                  60                  


Leu Gly Lys Met Leu Xaa Glu Lys Ala Met Glu Val Lys Ala Val Arg 
65                  70                  75                  80  


Ile Leu Val Pro Lys Ala Ala Ile Xaa His Asp Ile Pro Asn Lys Asn 
                85                  90                  95      


Xaa Lys Val Lys Ser Leu Gly His His Lys Gly Glu Phe Leu Gly Gln 
            100                 105                 110         


Ser Glu Gly Val Ile Glu Pro Asn Lys Glu Leu Ser Glu Val Lys Asn 
        115                 120                 125             


Val Leu Glu Lys Leu Lys Asn Ser Glu Arg Arg Leu Leu Gln Asp Lys 
    130                 135                 140                 


Glu Gly Leu Ser Asn Gln Leu Arg Val Gln Xaa Glu Val Arg Arg Ala 
145                 150                 155                 160 


Leu Ile Asp Lys Met Ser Xaa Xaa Leu Tyr Val Trp Xaa Phe 
                165                 170                 


<210> 4250
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4250
Met Glu Pro Ser Gln Cys Val Glu Glu Leu Glu Asp Asp 
1               5                   10              


<210> 4251
<211> 61
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 4251
Met Glu Pro Ser Gln Cys Val Glu Glu Leu Glu Asp Asp Val Phe Gln 
1               5                   10                  15      


Pro Glu Asp Gly Glu Pro Val Xaa Gln Pro Gly Ser Leu Leu Ser Ala 
            20                  25                  30          


Asp Leu Phe Ala Gln Ser Leu Leu Asp Cys Pro Leu Ser Arg Leu Gln 
        35                  40                  45              


Leu Phe Pro Leu Xaa His Cys Cys Gly Pro Gly Leu Arg 
    50                  55                  60      


<210> 4252
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 4252
Met Glu Pro Ser Gln Cys Val Glu Glu Leu Glu Asp Asp Val Phe Gln 
1               5                   10                  15      


Pro Glu Asp Gly Glu Pro Val Xaa Gln Pro Gly Ser Leu Leu Ser Ala 
            20                  25                  30          


Asp Leu Phe Ala Gln Ser Leu Leu Asp Cys Pro Leu Ser Arg Leu Gln 
        35                  40                  45              


Leu Phe Pro Leu Xaa His Cys Cys Gly Pro Gly Leu Arg Pro Xaa Ser 
    50                  55                  60                  


Gln Glu Asp Lys Ala Xaa Gln Xaa Leu Ser Pro Ala Ser Pro Ser Gln 
65                  70                  75                  80  


Gly Val Met Leu Pro Cys Gly Val Xaa Glu Glu Pro Gln Arg Leu Phe 
                85                  90                  95      


Tyr Ala Pro Ala Glu Pro Lys Ser Cys Val Val Ala Asp Pro Pro Leu 
            100                 105                 110         


Pro Ala Gln Pro Cys Phe Glu Trp Arg Arg Glu Gln Glu Arg Gly Arg 
        115                 120                 125             


Pro 
    


<210> 4253
<211> 163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 4253
Met Glu Pro Ser Gln Cys Val Glu Glu Leu Glu Asp Asp Val Phe Gln 
1               5                   10                  15      


Pro Glu Asp Gly Glu Pro Val Xaa Gln Pro Gly Ser Leu Leu Ser Ala 
            20                  25                  30          


Asp Leu Phe Ala Gln Ser Leu Leu Asp Cys Pro Leu Ser Arg Leu Gln 
        35                  40                  45              


Leu Phe Pro Leu Xaa His Cys Cys Gly Pro Gly Leu Arg Pro Xaa Ser 
    50                  55                  60                  


Gln Glu Asp Lys Ala Xaa Gln Xaa Leu Ser Pro Ala Ser Pro Ser Gln 
65                  70                  75                  80  


Gly Val Met Leu Pro Cys Gly Val Xaa Glu Glu Pro Gln Arg Leu Phe 
                85                  90                  95      


Tyr Gly Asn Ala Gly Tyr Arg Leu Pro Leu Pro Ala Ser Phe Pro Ala 
            100                 105                 110         


Val Leu Pro Ile Gly Glu Gln Pro Pro Glu Gly Gln Trp Gln His Gln 
        115                 120                 125             


Ala Glu His Gln Gln Asn Gln Asn Arg Val Trp Trp Gln Ile Leu Leu 
    130                 135                 140                 


Phe Leu His Asn Leu Ala Leu Asn Gly Glu Glu Asn Arg Asn Gly Ala 
145                 150                 155                 160 


Gly Pro Arg 
            


<210> 4254
<211> 184
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 4254
Met Glu Pro Ser Gln Cys Val Glu Glu Leu Glu Asp Asp Val Phe Gln 
1               5                   10                  15      


Pro Glu Asp Gly Glu Pro Val Xaa Gln Pro Gly Ser Leu Leu Ser Ala 
            20                  25                  30          


Asp Leu Phe Ala Gln Ser Leu Leu Asp Cys Pro Leu Ser Arg Leu Gln 
        35                  40                  45              


Leu Phe Pro Leu Xaa His Cys Cys Gly Pro Gly Leu Arg Pro Xaa Ser 
    50                  55                  60                  


Gln Glu Asp Lys Ala Xaa Gln Xaa Leu Ser Pro Ala Ser Pro Ser Gln 
65                  70                  75                  80  


Gly Val Met Leu Pro Cys Gly Val Xaa Glu Glu Pro Gln Arg Leu Phe 
                85                  90                  95      


Tyr Gly Asn Ala Gly Tyr Arg Leu Pro Leu Pro Ala Ser Phe Pro Ala 
            100                 105                 110         


Val Leu Pro Ile Gly Glu Gln Pro Pro Glu Gly Gln Trp Gln His Gln 
        115                 120                 125             


Ala Glu Val Gln Ile Ala Arg Lys Leu Gln Cys Ile Ala Asp Gln Phe 
    130                 135                 140                 


His Arg Leu His Val Gln Gln His Gln Gln Asn Gln Asn Arg Val Trp 
145                 150                 155                 160 


Trp Gln Ile Leu Leu Phe Leu His Asn Leu Ala Leu Asn Gly Glu Glu 
                165                 170                 175     


Asn Arg Asn Gly Ala Gly Pro Arg 
            180                 


<210> 4255
<211> 622
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<400> 4255
Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Xaa Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Xaa Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Xaa Ser Xaa Pro Ser 
                85                  90                  95      


Cys Gln Ser Xaa Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Xaa Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Xaa 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Xaa Cys Val Xaa Phe Leu Glu Arg Xaa Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Xaa Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg 
            180                 185                 190         


Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe 
        195                 200                 205             


Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu 
    210                 215                 220                 


His Xaa Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn 
225                 230                 235                 240 


Ile Gln Pro Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Pro Gln Glu 
                245                 250                 255     


Val Glu Ser Leu Gly Glu Xaa Tyr Asp Phe Asp Ser Ile Met His Tyr 
            260                 265                 270         


Ala Arg Asn Xaa Phe Ser Arg Gly Ile Phe Leu Asp Xaa Ile Val Pro 
        275                 280                 285             


Lys Tyr Glu Val Asn Gly Val Lys Pro Pro Ile Gly Gln Arg Xaa Arg 
    290                 295                 300                 


Leu Ser Lys Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro 
305                 310                 315                 320 


Ala Cys Gly Glu Xaa Leu Gln Asp Ser Xaa Gly Asn Phe Ser Ser Pro 
                325                 330                 335     


Glu Tyr Pro Asn Gly Tyr Ser Ala His Met His Cys Val Trp Arg Ile 
            340                 345                 350         


Ser Val Xaa Pro Gly Glu Lys Ile Ile Leu Asn Phe Xaa Ser Leu Asp 
        355                 360                 365             


Leu Tyr Arg Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp 
    370                 375                 380                 


Gly Phe Trp Arg Lys Ala Pro Leu Arg Gly Arg Phe Cys Gly Ser Lys 
385                 390                 395                 400 


Leu Pro Glu Pro Ile Val Ser Xaa Asp Ser Arg Leu Trp Val Glu Phe 
                405                 410                 415     


Arg Ser Ser Ser Asn Trp Val Gly Lys Gly Phe Phe Ala Val Tyr Glu 
            420                 425                 430         


Ala Ile Cys Gly Gly Asp Val Lys Lys Asp Tyr Gly His Ile Gln Ser 
        435                 440                 445             


Pro Asn Tyr Pro Asp Asp Tyr Arg Pro Ser Lys Val Cys Ile Trp Arg 
    450                 455                 460                 


Ile Gln Val Ser Glu Gly Phe His Val Gly Leu Xaa Phe Gln Ser Phe 
465                 470                 475                 480 


Glu Ile Glu Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg 
                485                 490                 495     


Asp Gly His Ser Glu Ser Ser Xaa Leu Ile Gly Arg Tyr Cys Gly Tyr 
            500                 505                 510         


Glu Lys Pro Asp Asp Ile Lys Ser Xaa Ser Ser Arg Leu Trp Leu Lys 
        515                 520                 525             


Phe Val Ser Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Val Asn Phe 
    530                 535                 540                 


Phe Lys Glu Val Asp Glu Cys Ser Arg Pro Asn Arg Gly Gly Cys Glu 
545                 550                 555                 560 


Gln Arg Cys Leu Asn Xaa Leu Gly Ser Tyr Lys Cys Ser Cys Asp Pro 
                565                 570                 575     


Gly Tyr Glu Leu Ala Pro Asp Lys Arg Arg Cys Glu Gly Cys Tyr Asp 
            580                 585                 590         


Leu Gln Val Gly Lys Pro Leu Leu Trp Asp Arg His Cys Phe Arg Leu 
        595                 600                 605             


Ser Xaa His Gly Pro Glu Met Leu Gly Xaa Ala Leu Arg Gly 
    610                 615                 620         


<210> 4256
<211> 717
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<400> 4256
Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Xaa Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Xaa Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Xaa Ser Xaa Pro Ser 
                85                  90                  95      


Cys Gln Ser Xaa Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Xaa Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Xaa 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Xaa Cys Val Xaa Phe Leu Glu Arg Xaa Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Xaa Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg 
            180                 185                 190         


Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe 
        195                 200                 205             


Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu 
    210                 215                 220                 


His Xaa Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn 
225                 230                 235                 240 


Ile Gln Pro Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Pro Gln Glu 
                245                 250                 255     


Val Glu Ser Leu Gly Glu Xaa Tyr Asp Phe Asp Ser Ile Met His Tyr 
            260                 265                 270         


Ala Arg Asn Xaa Phe Ser Arg Gly Ile Phe Leu Asp Xaa Ile Val Pro 
        275                 280                 285             


Lys Tyr Glu Val Asn Gly Val Lys Pro Pro Ile Gly Gln Arg Xaa Arg 
    290                 295                 300                 


Leu Ser Lys Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro 
305                 310                 315                 320 


Ala Cys Gly Glu Xaa Leu Gln Asp Ser Xaa Gly Asn Phe Ser Ser Pro 
                325                 330                 335     


Glu Tyr Pro Asn Gly Tyr Ser Ala His Met His Cys Val Trp Arg Ile 
            340                 345                 350         


Ser Val Xaa Pro Gly Glu Lys Ile Ile Leu Asn Phe Xaa Ser Leu Asp 
        355                 360                 365             


Leu Tyr Arg Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp 
    370                 375                 380                 


Gly Phe Trp Arg Lys Ala Pro Leu Arg Gly Arg Phe Cys Gly Ser Lys 
385                 390                 395                 400 


Leu Pro Glu Pro Ile Val Ser Xaa Asp Ser Arg Leu Trp Val Glu Phe 
                405                 410                 415     


Arg Ser Ser Ser Asn Trp Val Gly Lys Gly Phe Phe Ala Val Tyr Glu 
            420                 425                 430         


Ala Ile Cys Gly Gly Asp Val Lys Lys Asp Tyr Gly His Ile Gln Ser 
        435                 440                 445             


Pro Asn Tyr Pro Asp Asp Tyr Arg Pro Ser Lys Val Cys Ile Trp Arg 
    450                 455                 460                 


Ile Gln Val Ser Glu Gly Phe His Val Gly Leu Xaa Phe Gln Ser Phe 
465                 470                 475                 480 


Glu Ile Glu Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg 
                485                 490                 495     


Asp Gly His Ser Glu Ser Ser Xaa Leu Ile Gly Arg Tyr Cys Gly Tyr 
            500                 505                 510         


Glu Lys Pro Asp Asp Ile Lys Ser Xaa Ser Ser Arg Leu Trp Leu Lys 
        515                 520                 525             


Phe Val Ser Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Val Asn Phe 
    530                 535                 540                 


Phe Lys Glu Val Asp Glu Cys Ser Arg Pro Asn Arg Gly Gly Cys Glu 
545                 550                 555                 560 


Gln Arg Cys Leu Asn Xaa Leu Gly Ser Tyr Lys Cys Ser Cys Asp Pro 
                565                 570                 575     


Gly Tyr Glu Leu Ala Pro Asp Lys Arg Arg Cys Glu Ala Ala Cys Gly 
            580                 585                 590         


Gly Phe Leu Xaa Lys Leu Asn Gly Ser Ile Xaa Ser Pro Gly Trp Pro 
        595                 600                 605             


Lys Glu Tyr Pro Pro Asn Lys Asn Cys Ile Trp Gln Leu Val Ala Pro 
    610                 615                 620                 


Xaa Gln Tyr Arg Ile Ser Leu Gln Phe Asp Phe Phe Glu Xaa Glu Gly 
625                 630                 635                 640 


Asn Asp Val Cys Lys Tyr Asp Phe Val Glu Val Arg Ser Gly Leu Xaa 
                645                 650                 655     


Ala Asp Ser Lys Leu His Gly Lys Phe Cys Gly Ser Glu Lys Pro Glu 
            660                 665                 670         


Val Ile Xaa Ser Gln Tyr Asn Asn Met Arg Val Glu Phe Lys Ser Asp 
        675                 680                 685             


Asn Xaa Val Ser Lys Lys Gly Phe Lys Ala His Phe Phe Ser Gly Gly 
    690                 695                 700                 


Glu Leu Phe Gly Leu Leu Gly His Pro Pro Arg Arg Pro 
705                 710                 715         


<210> 4257
<211> 730
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<400> 4257
Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Xaa Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Xaa Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Xaa Ser Xaa Pro Ser 
                85                  90                  95      


Cys Gln Ser Xaa Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Xaa Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Xaa 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Xaa Cys Val Xaa Phe Leu Glu Arg Xaa Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Xaa Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg 
            180                 185                 190         


Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe 
        195                 200                 205             


Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu 
    210                 215                 220                 


His Xaa Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn 
225                 230                 235                 240 


Ile Gln Pro Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Pro Gln Glu 
                245                 250                 255     


Val Glu Ser Leu Gly Glu Xaa Tyr Asp Phe Asp Ser Ile Met His Tyr 
            260                 265                 270         


Ala Arg Asn Xaa Phe Ser Arg Gly Ile Phe Leu Asp Xaa Ile Val Pro 
        275                 280                 285             


Lys Tyr Glu Val Asn Gly Val Lys Pro Pro Ile Gly Gln Arg Xaa Arg 
    290                 295                 300                 


Leu Ser Lys Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro 
305                 310                 315                 320 


Ala Cys Gly Glu Xaa Leu Gln Asp Ser Xaa Gly Asn Phe Ser Ser Pro 
                325                 330                 335     


Glu Tyr Pro Asn Gly Tyr Ser Ala His Met His Cys Val Trp Arg Ile 
            340                 345                 350         


Ser Val Xaa Pro Gly Glu Lys Ile Ile Leu Asn Phe Xaa Ser Leu Asp 
        355                 360                 365             


Leu Tyr Arg Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp 
    370                 375                 380                 


Gly Phe Trp Arg Lys Ala Pro Leu Arg Gly Arg Phe Cys Gly Ser Lys 
385                 390                 395                 400 


Leu Pro Glu Pro Ile Val Ser Xaa Asp Ser Arg Leu Trp Val Glu Phe 
                405                 410                 415     


Arg Ser Ser Ser Asn Trp Val Gly Lys Gly Phe Phe Ala Val Tyr Glu 
            420                 425                 430         


Ala Ile Cys Gly Gly Asp Val Lys Lys Asp Tyr Gly His Ile Gln Ser 
        435                 440                 445             


Pro Asn Tyr Pro Asp Asp Tyr Arg Pro Ser Lys Val Cys Ile Trp Arg 
    450                 455                 460                 


Ile Gln Val Ser Glu Gly Phe His Val Gly Leu Xaa Phe Gln Ser Phe 
465                 470                 475                 480 


Glu Ile Glu Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg 
                485                 490                 495     


Asp Gly His Ser Glu Ser Ser Xaa Leu Ile Gly Arg Tyr Cys Gly Tyr 
            500                 505                 510         


Glu Lys Pro Asp Asp Ile Lys Ser Xaa Ser Ser Arg Leu Trp Leu Lys 
        515                 520                 525             


Phe Val Ser Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Val Asn Phe 
    530                 535                 540                 


Phe Lys Glu Val Asp Glu Cys Ser Arg Pro Asn Arg Gly Gly Cys Glu 
545                 550                 555                 560 


Gln Arg Cys Leu Asn Xaa Leu Gly Ser Tyr Lys Cys Ser Cys Asp Pro 
                565                 570                 575     


Gly Tyr Glu Leu Ala Pro Asp Lys Arg Arg Cys Glu Ala Ala Cys Gly 
            580                 585                 590         


Gly Phe Leu Xaa Lys Leu Asn Gly Ser Ile Xaa Ser Pro Gly Trp Pro 
        595                 600                 605             


Lys Glu Tyr Pro Pro Asn Lys Asn Cys Ile Trp Gln Leu Val Ala Pro 
    610                 615                 620                 


Xaa Gln Tyr Arg Ile Ser Leu Gln Phe Asp Phe Phe Glu Xaa Glu Gly 
625                 630                 635                 640 


Asn Asp Val Cys Lys Tyr Asp Phe Val Glu Val Arg Ser Gly Leu Xaa 
                645                 650                 655     


Ala Asp Ser Lys Leu His Gly Lys Phe Cys Gly Ser Glu Lys Pro Glu 
            660                 665                 670         


Val Ile Xaa Ser Gln Tyr Asn Asn Met Arg Val Glu Phe Lys Ser Asp 
        675                 680                 685             


Asn Xaa Val Ser Lys Lys Gly Phe Lys Ala His Phe Phe Ser Glu Lys 
    690                 695                 700                 


Arg Pro Ala Leu Gln Pro Pro Arg Gly Arg Pro His Gln Leu Lys Phe 
705                 710                 715                 720 


Arg Val Gln Lys Arg Asn Arg Xaa Pro Gln 
                725                 730 


<210> 4258
<211> 986
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<400> 4258
Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Xaa Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Xaa Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Xaa Ser Xaa Pro Ser 
                85                  90                  95      


Cys Gln Ser Xaa Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Xaa Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Xaa 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Xaa Cys Val Xaa Phe Leu Glu Arg Xaa Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Xaa Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg 
            180                 185                 190         


Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe 
        195                 200                 205             


Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu 
    210                 215                 220                 


His Xaa Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn 
225                 230                 235                 240 


Ile Gln Pro Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Pro Gln Glu 
                245                 250                 255     


Val Glu Ser Leu Gly Glu Xaa Tyr Asp Phe Asp Ser Ile Met His Tyr 
            260                 265                 270         


Ala Arg Asn Xaa Phe Ser Arg Gly Ile Phe Leu Asp Xaa Ile Val Pro 
        275                 280                 285             


Lys Tyr Glu Val Asn Gly Val Lys Pro Pro Ile Gly Gln Arg Xaa Arg 
    290                 295                 300                 


Leu Ser Lys Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro 
305                 310                 315                 320 


Ala Cys Gly Glu Xaa Leu Gln Asp Ser Xaa Gly Asn Phe Ser Ser Pro 
                325                 330                 335     


Glu Tyr Pro Asn Gly Tyr Ser Ala His Met His Cys Val Trp Arg Ile 
            340                 345                 350         


Ser Val Xaa Pro Gly Glu Lys Ile Ile Leu Asn Phe Xaa Ser Leu Asp 
        355                 360                 365             


Leu Tyr Arg Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp 
    370                 375                 380                 


Gly Phe Trp Arg Lys Ala Pro Leu Arg Gly Arg Phe Cys Gly Ser Lys 
385                 390                 395                 400 


Leu Pro Glu Pro Ile Val Ser Xaa Asp Ser Arg Leu Trp Val Glu Phe 
                405                 410                 415     


Arg Ser Ser Ser Asn Trp Val Gly Lys Gly Phe Phe Ala Val Tyr Glu 
            420                 425                 430         


Ala Ile Cys Gly Gly Asp Val Lys Lys Asp Tyr Gly His Ile Gln Ser 
        435                 440                 445             


Pro Asn Tyr Pro Asp Asp Tyr Arg Pro Ser Lys Val Cys Ile Trp Arg 
    450                 455                 460                 


Ile Gln Val Ser Glu Gly Phe His Val Gly Leu Xaa Phe Gln Ser Phe 
465                 470                 475                 480 


Glu Ile Glu Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg 
                485                 490                 495     


Asp Gly His Ser Glu Ser Ser Xaa Leu Ile Gly Arg Tyr Cys Gly Tyr 
            500                 505                 510         


Glu Lys Pro Asp Asp Ile Lys Ser Xaa Ser Ser Arg Leu Trp Leu Lys 
        515                 520                 525             


Phe Val Ser Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Val Asn Phe 
    530                 535                 540                 


Phe Lys Glu Val Asp Glu Cys Ser Arg Pro Asn Arg Gly Gly Cys Glu 
545                 550                 555                 560 


Gln Arg Cys Leu Asn Xaa Leu Gly Ser Tyr Lys Cys Ser Cys Asp Pro 
                565                 570                 575     


Gly Tyr Glu Leu Ala Pro Asp Lys Arg Arg Cys Glu Ala Ala Cys Gly 
            580                 585                 590         


Gly Phe Leu Xaa Lys Leu Asn Gly Ser Ile Xaa Ser Pro Gly Trp Pro 
        595                 600                 605             


Lys Glu Tyr Pro Pro Asn Lys Asn Cys Ile Trp Gln Leu Val Ala Pro 
    610                 615                 620                 


Xaa Gln Tyr Arg Ile Ser Leu Gln Phe Asp Phe Phe Glu Xaa Glu Gly 
625                 630                 635                 640 


Asn Asp Val Cys Lys Tyr Asp Phe Val Glu Val Arg Ser Gly Leu Xaa 
                645                 650                 655     


Ala Asp Ser Lys Leu His Gly Lys Phe Cys Gly Ser Glu Lys Pro Glu 
            660                 665                 670         


Val Ile Xaa Ser Gln Tyr Asn Asn Met Arg Val Glu Phe Lys Ser Asp 
        675                 680                 685             


Asn Xaa Val Ser Lys Lys Gly Phe Lys Ala His Phe Phe Ser Asp Lys 
    690                 695                 700                 


Asp Glu Cys Ser Lys Asp Asn Gly Gly Cys Gln Gln Asp Cys Val Asn 
705                 710                 715                 720 


Xaa Phe Gly Ser Tyr Glu Cys Gln Cys Arg Ser Gly Phe Val Leu His 
                725                 730                 735     


Asp Asn Lys His Asp Cys Lys Glu Ala Gly Cys Asp His Lys Val Xaa 
            740                 745                 750         


Ser Xaa Ser Gly Xaa Ile Xaa Ser Pro Asn Trp Pro Asp Lys Tyr Pro 
        755                 760                 765             


Ser Lys Lys Glu Cys Xaa Trp Ala Ile Ser Ser Xaa Pro Gly His Arg 
    770                 775                 780                 


Val Lys Leu Xaa Phe Met Glu Met Asp Ile Glu Ser Gln Pro Glu Cys 
785                 790                 795                 800 


Ala Tyr Asp His Leu Glu Val Phe Asp Gly Arg Asp Ala Lys Ala Pro 
                805                 810                 815     


Val Leu Gly Arg Phe Cys Gly Ser Lys Lys Pro Glu Pro Val Leu Ala 
            820                 825                 830         


Xaa Gly Ser Arg Met Phe Leu Arg Phe Tyr Ser Asp Asn Ser Val Gln 
        835                 840                 845             


Arg Lys Gly Phe Gln Ala Ser His Ala Xaa Glu Cys Gly Gly Gln Val 
    850                 855                 860                 


Arg Ala Asp Val Lys Xaa Lys Asp Leu Tyr Ser His Ala Gln Phe Gly 
865                 870                 875                 880 


Asp Asn Asn Tyr Pro Gly Gly Val Asp Cys Glu Trp Val Ile Val Ala 
                885                 890                 895     


Glu Glu Gly Tyr Gly Val Glu Leu Val Phe Gln Xaa Phe Glu Val Glu 
            900                 905                 910         


Glu Glu Xaa Asp Cys Gly Tyr Asp Tyr Met Glu Leu Phe Asp Gly Tyr 
        915                 920                 925             


Asp Ser Xaa Ala Pro Arg Leu Gly Arg Tyr Cys Gly Ser Gly Pro Pro 
    930                 935                 940                 


Glu Glu Val Tyr Ser Ala Gly Asp Ser Val Leu Val Lys Phe His Ser 
945                 950                 955                 960 


Asp Asp Xaa Ile Xaa Lys Lys Gly Phe His Leu Arg Tyr Xaa Ser Xaa 
                965                 970                 975     


Lys Phe Gln Asp Xaa Leu His Ser Arg Lys 
            980                 985     


<210> 4259
<211> 302
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<400> 4259
Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Xaa Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Xaa Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Xaa Ser Xaa Pro Ser 
                85                  90                  95      


Cys Gln Ser Xaa Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Xaa Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Xaa 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Xaa Cys Val Xaa Phe Leu Glu Arg Xaa Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Xaa Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg 
            180                 185                 190         


Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe 
        195                 200                 205             


Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu 
    210                 215                 220                 


His Xaa Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn 
225                 230                 235                 240 


Ile Gln Pro Gly Val Leu His Ser Ser Leu Leu Leu Leu Ser Cys Gly 
                245                 250                 255     


Ser Arg Asn Gly Ala Ser Phe Pro Cys Ser Leu Glu Ser Ser Ile His 
            260                 265                 270         


Gln Ala Leu Cys Trp Xaa Gly Leu Phe Leu Arg Pro Ser Pro Phe Pro 
        275                 280                 285             


Arg Leu Pro Leu Ala Ala Pro Arg Xaa Leu Arg Ala Gly Val 
    290                 295                 300         


<210> 4260
<211> 189
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<400> 4260
Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Xaa Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Xaa Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Xaa Ser Xaa Pro Ser 
                85                  90                  95      


Cys Gln Ser Xaa Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Xaa Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Xaa 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Xaa Cys Val Xaa Phe Leu Glu Arg Xaa Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Xaa Tyr Arg Pro Cys Gly Ser Gly Pro Pro Pro 
            180                 185                 


<210> 4261
<211> 61
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<400> 4261
Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Xaa Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Leu Pro Phe Leu Gly Xaa Leu Pro Trp Xaa Lys Arg Xaa 
    50                  55                  60      


<210> 4262
<211> 424
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<400> 4262
Met Gly Ser Leu Val Leu Xaa Leu Cys Ala Leu Phe Cys Leu Ala Ala 
1               5                   10                  15      


Tyr Leu Val Ser Gly Ser Pro Ile Met Asn Leu Glu Gln Ser Pro Leu 
            20                  25                  30          


Glu Glu Asp Met Ser Leu Phe Gly Asp Val Phe Ser Glu Gln Asp Gly 
        35                  40                  45              


Val Asp Phe Asn Xaa Leu Leu Gln Ser Met Lys Asp Glu Phe Leu Lys 
    50                  55                  60                  


Xaa Leu Asn Leu Ser Asp Ile Pro Xaa Gln Asp Ser Ala Lys Val Asp 
65                  70                  75                  80  


Pro Pro Glu Tyr Met Leu Glu Leu Tyr Asn Lys Phe Ala Xaa Asp Arg 
                85                  90                  95      


Xaa Ser Met Pro Ser Ala Asn Ile Ile Arg Ser Phe Lys Asn Glu Asp 
            100                 105                 110         


Leu Phe Ser Gln Pro Val Ser Phe Asn Gly Leu Arg Lys Tyr Pro Leu 
        115                 120                 125             


Leu Phe Asn Val Ser Ile Pro His His Glu Glu Val Ile Met Ala Glu 
    130                 135                 140                 


Leu Arg Leu Tyr Xaa Leu Val Gln Arg Asp Arg Met Ile Tyr Asp Gly 
145                 150                 155                 160 


Val Asp Arg Lys Ile Xaa Ile Phe Glu Val Leu Glu Ser Lys Gly Asp 
                165                 170                 175     


Asn Glu Gly Glu Arg Asn Met Leu Val Leu Val Ser Gly Glu Ile Tyr 
            180                 185                 190         


Gly Xaa Asn Ser Glu Trp Glu Xaa Phe Asp Val Xaa Asp Ala Ile Arg 
        195                 200                 205             


Arg Trp Gln Lys Ser Gly Ser Ser Xaa His Gln Leu Glu Val His Ile 
    210                 215                 220                 


Glu Ser Lys His Asp Glu Ala Glu Asp Ala Ser Ser Gly Arg Leu Glu 
225                 230                 235                 240 


Ile Asp Xaa Ser Ala Gln Asn Lys His Asn Pro Leu Leu Ile Val Phe 
                245                 250                 255     


Ser Asp Asp Gln Ser Ser Asp Lys Glu Arg Lys Glu Glu Leu Asn Glu 
            260                 265                 270         


Met Ile Ser His Glu Gln Leu Pro Glu Leu Asp Asn Leu Gly Leu Asp 
        275                 280                 285             


Ser Phe Ser Ser Gly Pro Gly Glu Glu Ala Leu Leu Gln Met Arg Ser 
    290                 295                 300                 


Asn Ile Ile Tyr Asp Ser Xaa Ala Arg Ile Arg Arg Asn Ala Lys Gly 
305                 310                 315                 320 


Asn Tyr Cys Lys Arg Xaa Pro Leu Tyr Ile Asp Phe Lys Glu Ile Gly 
                325                 330                 335     


Trp Asp Ser Trp Ile Ile Ala Pro Pro Gly Tyr Glu Ala Tyr Glu Cys 
            340                 345                 350         


Arg Gly Val Cys Asn Tyr Pro Leu Ala Glu His Leu Xaa Pro Xaa Lys 
        355                 360                 365             


His Ala Ile Ile Gln Ala Leu Val His Leu Lys Asn Ser Gln Lys Ala 
    370                 375                 380                 


Ser Lys Ala Cys Cys Val Pro Xaa Lys Leu Glu Pro Ile Ser Ile Leu 
385                 390                 395                 400 


Tyr Leu Asp Lys Gly Val Val Xaa Tyr Lys Phe Lys Tyr Glu Gly Met 
                405                 410                 415     


Ala Val Ser Glu Cys Gly Cys Arg 
            420                 


<210> 4263
<211> 392
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<400> 4263
Met Val Leu Leu Ser Ile Leu Arg Ile Leu Phe Leu Cys Glu Leu Val 
1               5                   10                  15      


Leu Phe Met Glu His Arg Ala Gln Met Ala Glu Gly Gly Gln Ser Ser 
            20                  25                  30          


Ile Ala Leu Leu Ala Glu Ala Pro Xaa Leu Pro Leu Ile Glu Glu Leu 
        35                  40                  45              


Leu Glu Glu Ser Pro Gly Glu Gln Pro Arg Lys Pro Arg Leu Leu Gly 
    50                  55                  60                  


His Ser Leu Arg Tyr Met Leu Glu Leu Tyr Arg Arg Ser Ala Asp Ser 
65                  70                  75                  80  


His Gly His Pro Arg Glu Asn Arg Xaa Ile Gly Ala Xaa Met Val Arg 
                85                  90                  95      


Leu Val Lys Pro Leu Xaa Asn Val Ala Arg Pro His Arg Gly Xaa Trp 
            100                 105                 110         


His Ile Gln Ile Leu Gly Phe Pro Leu Arg Pro Asn Arg Gly Leu Tyr 
        115                 120                 125             


Gln Leu Val Arg Ala Xaa Val Val Tyr Arg His His Leu Gln Leu Xaa 
    130                 135                 140                 


Arg Phe Asn Leu Ser Cys His Val Glu Pro Trp Val Gln Lys Asn Pro 
145                 150                 155                 160 


Xaa Asn His Phe Pro Ser Ser Glu Gly Asp Ser Ser Lys Pro Ser Leu 
                165                 170                 175     


Met Ser Asn Ala Trp Lys Glu Met Asp Ile Xaa Gln Leu Val Gln Gln 
            180                 185                 190         


Arg Phe Trp Asn Asn Lys Gly His Arg Ile Leu Arg Leu Arg Phe Met 
        195                 200                 205             


Cys Gln Gln Gln Lys Asp Ser Gly Gly Leu Glu Leu Trp His Gly Xaa 
    210                 215                 220                 


Ser Ser Leu Asp Ile Ala Phe Leu Leu Leu Tyr Phe Asn Asp Xaa His 
225                 230                 235                 240 


Lys Ser Ile Arg Lys Ala Lys Phe Leu Pro Arg Gly Met Glu Glu Phe 
                245                 250                 255     


Met Glu Arg Glu Ser Leu Leu Arg Arg Xaa Arg Gln Ala Asp Gly Ile 
            260                 265                 270         


Ser Ala Glu Val Xaa Ala Ser Ser Ser Lys His Ser Gly Pro Glu Asn 
        275                 280                 285             


Asn Gln Cys Ser Leu His Pro Phe Gln Ile Ser Phe Arg Gln Leu Gly 
    290                 295                 300                 


Trp Asp His Trp Ile Ile Ala Pro Pro Phe Tyr Xaa Pro Asn Tyr Cys 
305                 310                 315                 320 


Lys Gly Xaa Cys Leu Arg Val Leu Arg Asp Gly Leu Asn Ser Pro Asn 
                325                 330                 335     


His Ala Ile Ile Gln Asn Leu Ile Asn Gln Leu Val Asp Gln Ser Val 
            340                 345                 350         


Pro Arg Pro Ser Cys Val Pro Tyr Lys Tyr Val Pro Ile Ser Val Leu 
        355                 360                 365             


Met Ile Glu Ala Asn Gly Ser Ile Leu Tyr Lys Glu Tyr Glu Gly Met 
    370                 375                 380                 


Ile Ala Glu Ser Cys Xaa Cys Arg 
385                 390         


<210> 4264
<211> 396
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<400> 4264
Met Val Ala Gly Xaa Arg Cys Leu Leu Ala Leu Leu Leu Pro Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ala Gly Leu Val Pro Glu Leu Gly Arg Arg Lys 
            20                  25                  30          


Phe Ala Ala Ala Ser Ser Gly Arg Pro Ser Ser Gln Pro Ser Asp Glu 
        35                  40                  45              


Val Leu Ser Glu Phe Glu Leu Arg Leu Leu Ser Met Phe Gly Leu Lys 
    50                  55                  60                  


Gln Arg Pro Xaa Pro Ser Arg Asp Ala Val Val Pro Pro Tyr Met Leu 
65                  70                  75                  80  


Asp Leu Tyr Arg Arg His Ser Gly Gln Pro Gly Ser Pro Ala Pro Asp 
                85                  90                  95      


His Arg Leu Glu Arg Ala Ala Ser Arg Ala Asn Xaa Val Arg Ser Phe 
            100                 105                 110         


His His Glu Glu Ser Leu Glu Glu Leu Pro Glu Xaa Ser Gly Lys Xaa 
        115                 120                 125             


Xaa Arg Arg Phe Phe Phe Asn Leu Ser Ser Ile Pro Xaa Glu Glu Phe 
    130                 135                 140                 


Ile Xaa Ser Ala Glu Leu Gln Val Phe Arg Glu Gln Met Gln Asp Ala 
145                 150                 155                 160 


Leu Gly Asn Asn Ser Ser Phe His His Arg Ile Asn Ile Tyr Glu Ile 
                165                 170                 175     


Ile Lys Pro Ala Xaa Ala Asn Ser Lys Phe Pro Val Xaa Arg Leu Leu 
            180                 185                 190         


Asp Xaa Arg Leu Val Asn Gln Asn Ala Ser Arg Trp Glu Ser Phe Asp 
        195                 200                 205             


Val Xaa Pro Ala Val Met Arg Trp Xaa Ala Gln Gly His Ala Asn His 
    210                 215                 220                 


Gly Phe Val Val Glu Val Ala His Leu Glu Glu Lys Gln Gly Val Ser 
225                 230                 235                 240 


Lys Arg His Val Arg Ile Ser Arg Ser Leu His Gln Asp Glu His Ser 
                245                 250                 255     


Trp Ser Gln Ile Arg Pro Leu Leu Val Xaa Phe Gly His Asp Gly Lys 
            260                 265                 270         


Gly His Pro Leu His Lys Arg Glu Lys Arg Gln Ala Lys His Lys Gln 
        275                 280                 285             


Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 
    290                 295                 300                 


Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr 
305                 310                 315                 320 


His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His 
                325                 330                 335     


Leu Asn Ser Xaa Asn His Ala Ile Val Gln Xaa Leu Val Asn Ser Val 
            340                 345                 350         


Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Xaa Glu Leu Ser Ala 
        355                 360                 365             


Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn 
    370                 375                 380                 


Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
385                 390                 395     


<210> 4265
<211> 472
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<400> 4265
Met Ala Gly Ala Ser Arg Leu Leu Phe Leu Trp Leu Gly Cys Phe Cys 
1               5                   10                  15      


Val Ser Leu Ala Gln Gly Glu Arg Pro Lys Pro Pro Phe Pro Glu Leu 
            20                  25                  30          


Arg Lys Ala Val Pro Gly Asp Arg Xaa Ala Gly Gly Gly Pro Asp Ser 
        35                  40                  45              


Glu Leu Gln Pro Gln Asp Lys Val Ser Glu His Met Leu Arg Leu Tyr 
    50                  55                  60                  


Asp Arg Tyr Ser Xaa Val Gln Ala Ala Arg Xaa Pro Gly Ser Leu Glu 
65                  70                  75                  80  


Gly Gly Ser Gln Pro Trp Arg Pro Arg Leu Leu Arg Glu Gly Asn Xaa 
                85                  90                  95      


Val Arg Ser Phe Arg Ala Ala Ala Ala Glu Xaa Leu Glu Arg Lys Gly 
            100                 105                 110         


Leu Tyr Ile Phe Asn Leu Xaa Ser Leu Xaa Lys Ser Glu Asn Ile Leu 
        115                 120                 125             


Ser Ala Xaa Leu Tyr Phe Cys Ile Gly Glu Leu Gly Asn Ile Ser Leu 
    130                 135                 140                 


Ser Cys Pro Val Ser Gly Gly Cys Ser His His Ala Gln Arg Lys His 
145                 150                 155                 160 


Ile Gln Ile Asp Leu Ser Ala Trp Xaa Leu Lys Phe Ser Arg Asn Gln 
                165                 170                 175     


Ser Gln Leu Leu Gly His Leu Ser Val Asp Met Ala Lys Ser His Arg 
            180                 185                 190         


Asp Ile Met Ser Trp Leu Ser Lys Asp Ile Xaa Gln Leu Leu Arg Lys 
        195                 200                 205             


Ala Lys Glu Asn Glu Glu Phe Leu Ile Gly Phe Asn Ile Xaa Ser Lys 
    210                 215                 220                 


Gly Arg Gln Leu Pro Lys Arg Arg Leu Pro Phe Pro Glu Pro Tyr Ile 
225                 230                 235                 240 


Leu Val Tyr Ala Asn Asp Ala Ala Ile Ser Glu Pro Glu Ser Val Val 
                245                 250                 255     


Ser Ser Leu Gln Gly His Arg Asn Phe Pro Xaa Gly Xaa Val Pro Lys 
            260                 265                 270         


Trp Asp Ser His Ile Arg Ala Ala Leu Ser Ile Glu Arg Arg Lys Lys 
        275                 280                 285             


Arg Ser Xaa Gly Val Leu Leu Pro Leu Gln Asn Asn Glu Leu Pro Gly 
    290                 295                 300                 


Ala Glu Tyr Gln Tyr Lys Lys Asp Glu Val Trp Glu Glu Arg Lys Pro 
305                 310                 315                 320 


Tyr Lys Xaa Leu Gln Ala Gln Ala Pro Glu Lys Ser Lys Asn Lys Lys 
                325                 330                 335     


Lys Gln Arg Lys Gly Pro His Arg Lys Ser Gln Xaa Leu Gln Phe Asp 
            340                 345                 350         


Glu Gln Xaa Leu Lys Lys Ala Arg Arg Lys Gln Trp Ile Glu Pro Arg 
        355                 360                 365             


Asn Cys Ala Arg Arg Tyr Leu Lys Val Asp Phe Ala Asp Ile Gly Trp 
    370                 375                 380                 


Ser Glu Trp Ile Ile Ser Pro Lys Ser Phe Asp Ala Tyr Tyr Cys Ser 
385                 390                 395                 400 


Gly Ala Cys Gln Phe Pro Met Pro Lys Ser Leu Lys Pro Ser Asn His 
                405                 410                 415     


Ala Xaa Ile Gln Ser Ile Val Arg Ala Val Gly Val Val Pro Gly Ile 
            420                 425                 430         


Pro Glu Pro Cys Cys Val Pro Glu Lys Met Ser Ser Leu Ser Ile Leu 
        435                 440                 445             


Phe Phe Asp Glu Asn Lys Asn Val Val Leu Lys Val Tyr Pro Asn Met 
    450                 455                 460                 


Xaa Val Glu Ser Cys Ala Cys Arg 
465                 470         


<210> 4266
<211> 104
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 4266
Leu Ile Pro Glu Xaa Gly Lys Lys Lys Val Ala Glu Ile Gln Gly His 
1               5                   10                  15      


Ala Gly Gly Arg Arg Ser Gly Gln Ser His Glu Leu Leu Arg Asp Phe 
            20                  25                  30          


Glu Ala Xaa Leu Leu Gln Met Phe Gly Leu Arg Arg Arg Pro Gln Pro 
        35                  40                  45              


Ser Lys Ser Ala Val Ile Pro Asp Tyr Met Arg Asp Leu Tyr Arg Leu 
    50                  55                  60                  


Gln Ser Gly Glu Glu Glu Glu Glu Gln Ile His Ser Xaa Gly Leu Glu 
65                  70                  75                  80  


Tyr Pro Glu Arg Pro Ala Ser Arg Ala Asn Xaa Val Arg Ser Phe His 
                85                  90                  95      


His Glu Ala Ser Leu Arg Xaa Arg 
            100                 


<210> 4267
<211> 271
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<400> 4267
Met Phe Gly Leu Arg Arg Arg Pro Gln Pro Ser Lys Ser Ala Val Ile 
1               5                   10                  15      


Pro Asp Tyr Met Arg Asp Leu Tyr Arg Leu Gln Ser Gly Glu Glu Glu 
            20                  25                  30          


Glu Glu Gln Ile His Ser Xaa Gly Leu Glu Tyr Pro Glu Arg Pro Ala 
        35                  40                  45              


Ser Arg Ala Asn Xaa Val Arg Ser Phe His His Glu Glu His Leu Glu 
    50                  55                  60                  


Asn Ile Pro Gly Xaa Ser Glu Asn Ser Ala Phe Arg Phe Leu Phe Asn 
65                  70                  75                  80  


Leu Ser Ser Ile Pro Glu Asn Glu Val Ile Ser Ser Ala Glu Leu Arg 
                85                  90                  95      


Leu Phe Arg Glu Gln Val Asp Gln Gly Pro Asp Trp Glu Arg Gly Phe 
            100                 105                 110         


His Arg Ile Asn Ile Tyr Glu Val Met Lys Pro Pro Ala Glu Val Val 
        115                 120                 125             


Pro Gly His Leu Ile Xaa Arg Leu Leu Asp Xaa Arg Leu Val His His 
    130                 135                 140                 


Asn Val Xaa Arg Trp Glu Xaa Phe Asp Val Ser Pro Ala Val Leu Arg 
145                 150                 155                 160 


Trp Xaa Arg Glu Lys Gln Pro Asn Tyr Gly Leu Ala Ile Glu Val Xaa 
                165                 170                 175     


His Leu His Gln Xaa Arg Xaa His Gln Gly Gln His Val Arg Ile Ser 
            180                 185                 190         


Arg Ser Leu Pro Gln Gly Ser Gly Asn Trp Ala Gln Leu Arg Pro Leu 
        195                 200                 205             


Leu Val Xaa Phe Gly His Asp Gly Arg Gly His Ala Leu Xaa Arg Arg 
    210                 215                 220                 


Arg Arg Ala Lys Arg Ser Pro Lys His His Ser Gln Arg Ala Arg Lys 
225                 230                 235                 240 


Lys Asn Lys Asn Cys Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp 
                245                 250                 255     


Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala 
            260                 265                 270     


<210> 4268
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<400> 4268
Met Ile Pro Gly Asn Arg Met Leu Met Val Val Leu Leu Cys Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ser His Ala Ser Leu Ile Pro Glu Xaa Gly Lys 
            20                  25                  30          


Lys Lys Val Ala Glu Ile Gln Gly His Ala Gly Gly Arg Arg Ser Gly 
        35                  40                  45              


Gln Ser His Glu Leu Leu Arg Asp Phe Glu Ala Xaa Leu Leu Gln Met 
    50                  55                  60                  


Phe Gly Leu Arg Arg Arg Pro Gln Pro Ser Lys Ser Ala Val Ile Pro 
65                  70                  75                  80  


Asp Tyr Met Arg Asp Leu Tyr Arg Leu Gln Ser Gly Glu Glu Glu Glu 
                85                  90                  95      


Glu Gln Ile His Ser Xaa Gly Leu Glu Tyr Pro Glu Arg Pro 
            100                 105                 110 


<210> 4269
<211> 408
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<400> 4269
Met Ile Pro Gly Asn Arg Met Leu Met Val Val Leu Leu Cys Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ser His Ala Ser Leu Ile Pro Glu Xaa Gly Lys 
            20                  25                  30          


Lys Lys Val Ala Glu Ile Gln Gly His Ala Gly Gly Arg Arg Ser Gly 
        35                  40                  45              


Gln Ser His Glu Leu Leu Arg Asp Phe Glu Ala Xaa Leu Leu Gln Met 
    50                  55                  60                  


Phe Gly Leu Arg Arg Arg Pro Gln Pro Ser Lys Ser Ala Val Ile Pro 
65                  70                  75                  80  


Asp Tyr Met Arg Asp Leu Tyr Arg Leu Gln Ser Gly Glu Glu Glu Glu 
                85                  90                  95      


Glu Gln Ile His Ser Xaa Gly Leu Glu Tyr Pro Glu Arg Pro Ala Ser 
            100                 105                 110         


Arg Ala Asn Xaa Val Arg Ser Phe His His Glu Glu His Leu Glu Asn 
        115                 120                 125             


Ile Pro Gly Xaa Ser Glu Asn Ser Ala Phe Arg Phe Leu Phe Asn Leu 
    130                 135                 140                 


Ser Ser Ile Pro Glu Asn Glu Val Ile Ser Ser Ala Glu Leu Arg Leu 
145                 150                 155                 160 


Phe Arg Glu Gln Val Asp Gln Gly Pro Asp Trp Glu Arg Gly Phe His 
                165                 170                 175     


Arg Ile Asn Ile Tyr Glu Val Met Lys Pro Pro Ala Glu Val Val Pro 
            180                 185                 190         


Gly His Leu Ile Xaa Arg Leu Leu Asp Xaa Arg Leu Val His His Asn 
        195                 200                 205             


Val Xaa Arg Trp Glu Xaa Phe Asp Val Ser Pro Ala Val Leu Arg Trp 
    210                 215                 220                 


Xaa Arg Glu Lys Gln Pro Asn Tyr Gly Leu Ala Ile Glu Val Xaa His 
225                 230                 235                 240 


Leu His Gln Xaa Arg Xaa His Gln Gly Gln His Val Arg Ile Ser Arg 
                245                 250                 255     


Ser Leu Pro Gln Gly Ser Gly Asn Trp Ala Gln Leu Arg Pro Leu Leu 
            260                 265                 270         


Val Xaa Phe Gly His Asp Gly Arg Gly His Ala Leu Xaa Arg Arg Arg 
        275                 280                 285             


Arg Ala Lys Arg Ser Pro Lys His His Ser Gln Arg Ala Arg Lys Lys 
    290                 295                 300                 


Asn Lys Asn Cys Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp Val 
305                 310                 315                 320 


Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala Phe Tyr 
                325                 330                 335     


Cys His Gly Asp Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Xaa 
            340                 345                 350         


Asn His Ala Ile Val Gln Xaa Leu Val Asn Ser Val Asn Ser Ser Ile 
        355                 360                 365             


Pro Lys Ala Cys Cys Val Pro Xaa Glu Leu Ser Ala Ile Ser Met Leu 
    370                 375                 380                 


Tyr Leu Asp Glu Tyr Asp Lys Val Val Leu Lys Asn Tyr Gln Glu Met 
385                 390                 395                 400 


Val Val Glu Gly Cys Gly Cys Arg 
                405             


<210> 4270
<211> 29
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<400> 4270
Asn Xaa Val Arg Ser Phe His His Glu Gly Gln Ser Leu Pro Pro Val 
1               5                   10                  15      


Cys Val Gly Glu Gly Trp Trp Asp Trp Leu Glu Gly Gln 
            20                  25                  


<210> 4271
<211> 454
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<400> 4271
Met His Leu Xaa Val Phe Leu Leu Lys Gly Ile Val Gly Phe Leu Trp 
1               5                   10                  15      


Ser Cys Trp Val Leu Val Gly Tyr Ala Lys Gly Gly Leu Gly Asp Asn 
            20                  25                  30          


His Val His Ser Ser Phe Ile Tyr Arg Arg Leu Arg Asn His Glu Arg 
        35                  40                  45              


Arg Glu Ile Gln Arg Glu Ile Leu Ser Ile Leu Gly Leu Pro His Arg 
    50                  55                  60                  


Pro Arg Pro Phe Ser Pro Gly Lys Gln Ala Ser Ser Ala Pro Leu Phe 
65                  70                  75                  80  


Met Leu Asp Leu Tyr Asn Ala Met Xaa Asn Glu Glu Asn Pro Glu Glu 
                85                  90                  95      


Ser Glu Tyr Ser Val Arg Ala Ser Leu Ala Glu Glu Xaa Arg Gly Ala 
            100                 105                 110         


Arg Lys Gly Tyr Pro Ala Ser Pro Asn Gly Tyr Pro Arg Arg Ile Gln 
        115                 120                 125             


Leu Ser Arg Xaa Xaa Pro Leu Xaa Xaa Gln Ser Pro Pro Leu Ala Ser 
    130                 135                 140                 


Leu His Asp Xaa Asn Phe Leu Asn Asp Ala Asp Met Val Met Ser Phe 
145                 150                 155                 160 


Val Asn Leu Val Glu Arg Asp Lys Asp Phe Ser His Gln Arg Arg His 
                165                 170                 175     


Tyr Lys Glu Phe Arg Phe Asp Leu Xaa Gln Ile Pro His Gly Glu Ala 
            180                 185                 190         


Val Xaa Ala Ala Glu Phe Arg Ile Tyr Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Phe Glu Asn Glu Xaa Ile Lys Ile Ser Ile Tyr Gln Ile Ile Lys Glu 
    210                 215                 220                 


Tyr Xaa Asn Arg Asp Ala Asp Leu Phe Leu Leu Asp Xaa Arg Lys Ala 
225                 230                 235                 240 


Gln Ala Leu Asp Val Gly Trp Leu Val Phe Asp Ile Xaa Val Xaa Ser 
                245                 250                 255     


Asn His Trp Val Ile Asn Pro Gln Asn Asn Leu Gly Leu Gln Leu Cys 
            260                 265                 270         


Ala Glu Xaa Gly Asp Gly Arg Ser Ile Asn Val Lys Ser Ala Gly Leu 
        275                 280                 285             


Val Gly Arg Gln Gly Pro Gln Ser Lys Gln Pro Phe Met Val Ala Phe 
    290                 295                 300                 


Phe Lys Ala Ser Glu Val Leu Leu Arg Ser Val Arg Ala Ala Asn Lys 
305                 310                 315                 320 


Arg Lys Asn Gln Asn Arg Asn Lys Ser Ser Ser His Gln Asp Ser Ser 
                325                 330                 335     


Arg Met Ser Ser Val Gly Asp Tyr Asn Xaa Ser Glu Gln Lys Gln Ala 
            340                 345                 350         


Cys Lys Lys His Glu Leu Tyr Val Ser Phe Arg Asp Leu Gly Trp Gln 
        355                 360                 365             


Asp Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala Phe Tyr Cys Asp Gly 
    370                 375                 380                 


Glu Cys Ser Phe Pro Leu Asn Ala His Met Asn Ala Xaa Asn His Ala 
385                 390                 395                 400 


Ile Val Gln Xaa Leu Val His Leu Met Phe Pro Asp His Val Pro Lys 
                405                 410                 415     


Pro Cys Cys Ala Pro Xaa Lys Leu Asn Ala Ile Ser Val Leu Tyr Phe 
            420                 425                 430         


Asp Asp Ser Ser Asn Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val 
        435                 440                 445             


Arg Ser Cys Gly Cys His 
    450                 


<210> 4272
<211> 513
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<400> 4272
Met Pro Gly Leu Gly Arg Arg Ala Gln Trp Leu Cys Trp Trp Trp Gly 
1               5                   10                  15      


Leu Leu Cys Ser Cys Cys Gly Pro Pro Pro Leu Arg Pro Pro Leu Pro 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Leu Leu Gly Asp Gly Gly 
        35                  40                  45              


Ser Pro Gly Arg Xaa Glu Gln Pro Pro Pro Ser Pro Gln Ser Ser Ser 
    50                  55                  60                  


Gly Phe Leu Tyr Arg Arg Leu Lys Xaa Gln Glu Lys Arg Glu Met Gln 
65                  70                  75                  80  


Lys Glu Ile Leu Ser Val Leu Gly Leu Pro His Arg Pro Arg Pro Leu 
                85                  90                  95      


His Gly Leu Gln Gln Pro Gln Pro Pro Ala Leu Arg Gln Gln Glu Glu 
            100                 105                 110         


Gln Gln Gln Gln Gln Gln Leu Pro Arg Gly Glu Pro Pro Pro Gly Arg 
        115                 120                 125             


Leu Lys Ser Ala Pro Leu Phe Met Leu Asp Leu Tyr Asn Ala Leu Ser 
    130                 135                 140                 


Ala Asp Asn Asp Glu Asp Gly Ala Ser Glu Gly Glu Arg Gln Gln Ser 
145                 150                 155                 160 


Trp Pro His Glu Ala Ala Ser Ser Ser Gln Arg Arg Gln Pro Pro Pro 
                165                 170                 175     


Gly Ala Ala His Pro Leu Asn Arg Lys Ser Leu Leu Ala Pro Gly Ser 
            180                 185                 190         


Gly Ser Gly Gly Ala Ser Pro Leu Xaa Ser Ala Gln Asp Ser Ala Phe 
        195                 200                 205             


Leu Asn Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu Tyr 
    210                 215                 220                 


Asp Lys Glu Phe Ser Pro Arg Gln Arg His His Lys Glu Phe Lys Phe 
225                 230                 235                 240 


Asn Leu Ser Gln Ile Pro Glu Gly Glu Val Val Xaa Ala Ala Glu Phe 
                245                 250                 255     


Arg Ile Tyr Lys Asp Cys Val Met Gly Ser Phe Lys Asn Gln Xaa Phe 
            260                 265                 270         


Leu Ile Ser Ile Tyr Gln Val Leu Gln Glu His Gln His Arg Asp Ser 
        275                 280                 285             


Asp Leu Phe Leu Leu Asp Xaa Arg Val Val Trp Ala Ser Glu Glu Gly 
    290                 295                 300                 


Trp Leu Glu Phe Asp Ile Xaa Ala Xaa Ser Asn Leu Trp Val Val Xaa 
305                 310                 315                 320 


Pro Gln His Asn Met Gly Leu Gln Leu Ser Val Val Xaa Arg Asp Gly 
                325                 330                 335     


Val His Val His Pro Arg Ala Ala Gly Leu Val Gly Arg Asp Gly Pro 
            340                 345                 350         


Tyr Asp Lys Gln Pro Phe Met Val Ala Phe Phe Lys Val Ser Glu Val 
        355                 360                 365             


His Val Arg Xaa Xaa Arg Ser Ala Ser Ser Arg Arg Arg Gln Gln Ser 
    370                 375                 380                 


Arg Asn Arg Ser Xaa Gln Ser Gln Asp Val Ala Arg Val Ser Ser Ala 
385                 390                 395                 400 


Ser Asp Tyr Asn Ser Ser Glu Leu Lys Xaa Ala Cys Arg Lys His Glu 
                405                 410                 415     


Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala 
            420                 425                 430         


Pro Lys Gly Tyr Ala Ala Asn Tyr Cys Asp Gly Glu Cys Ser Phe Pro 
        435                 440                 445             


Leu Asn Ala His Met Asn Ala Xaa Asn His Ala Ile Val Gln Xaa Leu 
    450                 455                 460                 


Val His Leu Met Asn Pro Glu Tyr Val Pro Lys Pro Cys Cys Ala Pro 
465                 470                 475                 480 


Xaa Lys Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Asn Ser Asn 
                485                 490                 495     


Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys 
            500                 505                 510         


His 
    


<210> 4273
<211> 365
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<400> 4273
Met His Val Arg Ser Leu Arg Ala Ala Ala Pro His Ser Phe Val Ala 
1               5                   10                  15      


Leu Trp Ala Pro Leu Phe Leu Leu Arg Ser Ala Leu Ala Asp Phe Ser 
            20                  25                  30          


Leu Asp Asn Glu Val His Ser Ser Phe Ile His Arg Arg Leu Arg Ser 
        35                  40                  45              


Gln Glu Arg Arg Glu Met Gln Arg Glu Ile Leu Ser Ile Leu Gly Leu 
    50                  55                  60                  


Pro His Arg Pro Arg Pro His Leu Gln Gly Lys His Asn Ser Ala Pro 
65                  70                  75                  80  


Met Phe Met Leu Asp Leu Tyr Asn Ala Met Ala Val Glu Glu Gly Gly 
                85                  90                  95      


Gly Pro Gly Gly Gln Gly Phe Ser Tyr Pro Tyr Lys Ala Val Phe Ser 
            100                 105                 110         


Xaa Gln Gly Pro Pro Leu Ala Ser Leu Gln Asp Ser His Phe Leu Xaa 
        115                 120                 125             


Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu His Asp Lys 
    130                 135                 140                 


Glu Phe Phe His Pro Arg Tyr His His Arg Glu Phe Arg Phe Asp Leu 
145                 150                 155                 160 


Ser Lys Ile Pro Glu Gly Glu Ala Val Xaa Ala Ala Glu Phe Arg Ile 
                165                 170                 175     


Tyr Lys Asp Tyr Ile Arg Glu Arg Phe Asp Asn Glu Xaa Phe Arg Ile 
            180                 185                 190         


Ser Val Tyr Gln Val Leu Gln Glu His Leu Gly Arg Glu Ser Asp Leu 
        195                 200                 205             


Phe Leu Leu Asp Ser Arg Xaa Leu Trp Ala Ser Glu Glu Gly Trp Leu 
    210                 215                 220                 


Val Phe Asp Ile Xaa Ala Xaa Ser Asn His Trp Val Val Asn Pro Arg 
225                 230                 235                 240 


His Asn Leu Gly Leu Gln Leu Ser Val Glu Xaa Leu Asp Glu Asn Ser 
                245                 250                 255     


Ser Ser Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr Val Ser 
            260                 265                 270         


Phe Arg Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu Gly Tyr 
        275                 280                 285             


Ala Ala Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn Ser Tyr 
    290                 295                 300                 


Met Asn Ala Xaa Asn His Ala Ile Val Gln Xaa Leu Val His Phe Ile 
305                 310                 315                 320 


Asn Pro Glu Xaa Val Pro Lys Pro Cys Cys Ala Pro Xaa Gln Leu Asn 
                325                 330                 335     


Ala Ile Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile Leu Lys 
            340                 345                 350         


Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
        355                 360                 365 


<210> 4274
<211> 412
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<400> 4274
Met His Val Arg Ser Leu Arg Ala Ala Ala Pro His Ser Phe Val Ala 
1               5                   10                  15      


Leu Trp Ala Pro Leu Phe Leu Leu Arg Ser Ala Leu Ala Asp Phe Ser 
            20                  25                  30          


Leu Asp Asn Glu Val His Ser Ser Phe Ile His Arg Arg Leu Arg Ser 
        35                  40                  45              


Gln Glu Arg Arg Glu Met Gln Arg Glu Ile Leu Ser Ile Leu Gly Leu 
    50                  55                  60                  


Pro His Arg Pro Arg Pro His Leu Gln Gly Lys His Asn Ser Ala Pro 
65                  70                  75                  80  


Met Phe Met Leu Asp Leu Tyr Asn Ala Met Ala Val Glu Glu Gly Gly 
                85                  90                  95      


Gly Pro Gly Gly Gln Gly Phe Ser Tyr Pro Tyr Lys Ala Val Phe Ser 
            100                 105                 110         


Xaa Gln Gly Pro Pro Leu Ala Ser Leu Gln Asp Ser His Phe Leu Xaa 
        115                 120                 125             


Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu His Asp Lys 
    130                 135                 140                 


Glu Phe Phe His Pro Arg Tyr His His Arg Glu Phe Arg Phe Asp Leu 
145                 150                 155                 160 


Ser Lys Ile Pro Glu Gly Glu Ala Val Xaa Ala Ala Glu Phe Arg Ile 
                165                 170                 175     


Tyr Lys Asp Tyr Ile Arg Glu Arg Phe Asp Asn Glu Xaa Phe Arg Ile 
            180                 185                 190         


Ser Val Tyr Gln Val Leu Gln Glu His Leu Gly Arg Glu Ser Asp Leu 
        195                 200                 205             


Phe Leu Leu Asp Ser Arg Xaa Leu Trp Ala Ser Glu Glu Gly Trp Leu 
    210                 215                 220                 


Val Phe Asp Ile Xaa Ala Xaa Ser Asn His Trp Val Val Asn Pro Arg 
225                 230                 235                 240 


His Asn Leu Gly Leu Gln Leu Ser Val Glu Xaa Leu Asp Gly Gln Ser 
                245                 250                 255     


Ile Asn Pro Lys Leu Ala Gly Leu Ile Gly Arg His Gly Pro Gln Asn 
            260                 265                 270         


Lys Gln Pro Phe Met Val Ala Phe Phe Lys Ala Xaa Glu Val His Phe 
        275                 280                 285             


Arg Ser Ile Arg Ser Xaa Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser 
    290                 295                 300                 


Lys Xaa Pro Lys Asn Gln Glu Ala Leu Arg Met Ala Asn Val Ala Glu 
305                 310                 315                 320 


Asn Ser Ser Ser Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr 
                325                 330                 335     


Val Ser Phe Arg Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu 
            340                 345                 350         


Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn 
        355                 360                 365             


Ser Tyr Met Asn Ala Xaa Asn His Ala Ile Val Gln Xaa Leu Val Gly 
    370                 375                 380                 


Val Xaa Pro Ser Trp Gly Val Val Xaa Trp Ala Gly Gln Ala Ala Gly 
385                 390                 395                 400 


Pro Pro Asp Pro Ala Ala Ser Lys Leu Gly Pro Glu 
                405                 410         


<210> 4275
<211> 431
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<400> 4275
Met His Val Arg Ser Leu Arg Ala Ala Ala Pro His Ser Phe Val Ala 
1               5                   10                  15      


Leu Trp Ala Pro Leu Phe Leu Leu Arg Ser Ala Leu Ala Asp Phe Ser 
            20                  25                  30          


Leu Asp Asn Glu Val His Ser Ser Phe Ile His Arg Arg Leu Arg Ser 
        35                  40                  45              


Gln Glu Arg Arg Glu Met Gln Arg Glu Ile Leu Ser Ile Leu Gly Leu 
    50                  55                  60                  


Pro His Arg Pro Arg Pro His Leu Gln Gly Lys His Asn Ser Ala Pro 
65                  70                  75                  80  


Met Phe Met Leu Asp Leu Tyr Asn Ala Met Ala Val Glu Glu Gly Gly 
                85                  90                  95      


Gly Pro Gly Gly Gln Gly Phe Ser Tyr Pro Tyr Lys Ala Val Phe Ser 
            100                 105                 110         


Xaa Gln Gly Pro Pro Leu Ala Ser Leu Gln Asp Ser His Phe Leu Xaa 
        115                 120                 125             


Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu His Asp Lys 
    130                 135                 140                 


Glu Phe Phe His Pro Arg Tyr His His Arg Glu Phe Arg Phe Asp Leu 
145                 150                 155                 160 


Ser Lys Ile Pro Glu Gly Glu Ala Val Xaa Ala Ala Glu Phe Arg Ile 
                165                 170                 175     


Tyr Lys Asp Tyr Ile Arg Glu Arg Phe Asp Asn Glu Xaa Phe Arg Ile 
            180                 185                 190         


Ser Val Tyr Gln Val Leu Gln Glu His Leu Gly Arg Glu Ser Asp Leu 
        195                 200                 205             


Phe Leu Leu Asp Ser Arg Xaa Leu Trp Ala Ser Glu Glu Gly Trp Leu 
    210                 215                 220                 


Val Phe Asp Ile Xaa Ala Xaa Ser Asn His Trp Val Val Asn Pro Arg 
225                 230                 235                 240 


His Asn Leu Gly Leu Gln Leu Ser Val Glu Xaa Leu Asp Gly Gln Ser 
                245                 250                 255     


Ile Asn Pro Lys Leu Ala Gly Leu Ile Gly Arg His Gly Pro Gln Asn 
            260                 265                 270         


Lys Gln Pro Phe Met Val Ala Phe Phe Lys Ala Xaa Glu Val His Phe 
        275                 280                 285             


Arg Ser Ile Arg Ser Xaa Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser 
    290                 295                 300                 


Lys Xaa Pro Lys Asn Gln Glu Ala Leu Arg Met Ala Asn Val Ala Glu 
305                 310                 315                 320 


Asn Ser Ser Ser Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr 
                325                 330                 335     


Val Ser Phe Arg Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu 
            340                 345                 350         


Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn 
        355                 360                 365             


Ser Tyr Met Asn Ala Xaa Asn His Ala Ile Val Gln Xaa Leu Val His 
    370                 375                 380                 


Phe Ile Asn Pro Glu Xaa Val Pro Lys Pro Cys Cys Ala Pro Xaa Gln 
385                 390                 395                 400 


Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile 
                405                 410                 415     


Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
            420                 425                 430     


<210> 4276
<211> 297
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<400> 4276
Xaa Pro Pro Leu Ala Ser Leu Gln Asp Ser His Phe Leu Xaa Asp Ala 
1               5                   10                  15      


Asp Met Val Met Ser Phe Val Asn Leu Val Glu His Asp Lys Glu Phe 
            20                  25                  30          


Phe His Pro Arg Tyr His His Arg Glu Phe Arg Phe Asp Leu Ser Lys 
        35                  40                  45              


Ile Pro Glu Gly Glu Ala Val Xaa Ala Ala Glu Phe Arg Ile Tyr Lys 
    50                  55                  60                  


Asp Tyr Ile Arg Glu Arg Phe Asp Asn Glu Xaa Phe Arg Ile Ser Val 
65                  70                  75                  80  


Tyr Gln Val Leu Gln Glu His Leu Gly Ser Xaa Gly Xaa Cys Cys Met 
                85                  90                  95      


Pro Cys Leu Arg Ala Ser Xaa Arg Xaa Asn Gln Xaa Arg Val Pro Ala 
            100                 105                 110         


Leu Trp Lys Leu Xaa Phe Gln Gln Arg Arg Gly His Gly Arg Glu Ser 
        115                 120                 125             


Asp Leu Phe Leu Leu Asp Ser Arg Xaa Leu Trp Ala Ser Glu Glu Gly 
    130                 135                 140                 


Trp Leu Val Phe Asp Ile Xaa Ala Xaa Ser Asn His Trp Val Val Asn 
145                 150                 155                 160 


Pro Arg His Asn Leu Gly Leu Gln Leu Ser Val Glu Xaa Leu Asp Gly 
                165                 170                 175     


Gln Ser Ile Asn Pro Lys Leu Ala Gly Leu Ile Gly Arg His Gly Pro 
            180                 185                 190         


Gln Asn Lys Gln Pro Phe Met Val Ala Phe Phe Lys Ala Xaa Glu Val 
        195                 200                 205             


His Phe Arg Ser Ile Arg Ser Xaa Gly Ser Lys Gln Arg Ser Gln Asn 
    210                 215                 220                 


Arg Ser Lys Xaa Pro Lys Asn Gln Glu Ala Leu Arg Met Ala Asn Val 
225                 230                 235                 240 


Ala Glu Asn Ser Ser Ser Asp Gln Arg Gln Ala Cys Lys Lys His Glu 
                245                 250                 255     


Leu Tyr Val Ser Phe Arg Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala 
            260                 265                 270         


Pro Glu Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro 
        275                 280                 285             


Leu Asn Ser Tyr Met Asn Ala Xaa Asn 
    290                 295         


<210> 4277
<211> 402
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<400> 4277
Met Ala Ala Arg Pro Gly Pro Leu Trp Leu Leu Gly Leu Xaa Leu Cys 
1               5                   10                  15      


Ala Leu Gly Gly Gly Gly Pro Gly Leu Arg Pro Pro Pro Gly Cys Pro 
            20                  25                  30          


Gln Arg Arg Leu Gly Ala Arg Glu Arg Arg Asp Val Gln Arg Glu Ile 
        35                  40                  45              


Leu Ala Val Leu Gly Leu Pro Gly Arg Pro Arg Pro Arg Ala Pro Pro 
    50                  55                  60                  


Ala Ala Ser Arg Leu Pro Ala Ser Ala Pro Leu Phe Met Leu Asp Leu 
65                  70                  75                  80  


Tyr His Ala Met Ala Gly Asp Asp Asp Glu Asp Gly Ala Pro Ala Glu 
                85                  90                  95      


Gln Arg Leu Gly Arg Ala Asp Leu Val Met Ser Phe Val Asn Met Val 
            100                 105                 110         


Glu Arg Asp Arg Ala Leu Gly His Gln Glu Pro His Trp Lys Glu Phe 
        115                 120                 125             


Arg Phe Asp Leu Xaa Gln Ile Pro Ala Gly Glu Ala Val Xaa Ala Ala 
    130                 135                 140                 


Glu Phe Arg Ile Tyr Lys Val Pro Ser Ile His Leu Leu Asn Arg Xaa 
145                 150                 155                 160 


Leu His Val Ser Met Phe Gln Val Val Gln Glu Gln Ser Asn Arg Glu 
                165                 170                 175     


Ser Asp Leu Phe Phe Leu Asp Leu Gln Xaa Leu Arg Ala Gly Asp Glu 
            180                 185                 190         


Gly Trp Leu Val Leu Asp Val Xaa Ala Ala Ser Asp Cys Trp Leu Leu 
        195                 200                 205             


Lys Arg His Lys Asp Leu Gly Leu Arg Leu Tyr Val Glu Xaa Glu Asp 
    210                 215                 220                 


Gly His Ser Val Asp Pro Gly Leu Ala Gly Leu Leu Gly Gln Arg Ala 
225                 230                 235                 240 


Pro Arg Ser Gln Gln Pro Phe Val Val Xaa Phe Phe Arg Ala Ser Pro 
                245                 250                 255     


Ser Pro Ile Arg Xaa Pro Arg Ala Val Arg Pro Leu Arg Arg Arg Gln 
            260                 265                 270         


Pro Lys Lys Ser Asn Glu Leu Pro Gln Ala Asn Arg Leu Pro Gly Ile 
        275                 280                 285             


Phe Asp Asp Val Arg Gly Ser His Gly Arg Gln Val Cys Arg Arg His 
    290                 295                 300                 


Glu Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Leu Asp Trp Val Ile 
305                 310                 315                 320 


Ala Pro Gln Gly Tyr Ser Ala Tyr Tyr Cys Glu Gly Glu Cys Ser Phe 
                325                 330                 335     


Pro Leu Asp Ser Cys Met Asn Ala Xaa Asn His Ala Ile Leu Gln Ser 
            340                 345                 350         


Leu Val His Leu Met Lys Pro Asn Ala Val Pro Lys Ala Cys Cys Ala 
        355                 360                 365             


Pro Xaa Lys Leu Ser Ala Xaa Ser Val Leu Tyr Tyr Asp Ser Ser Asn 
    370                 375                 380                 


Asn Val Ile Leu Arg Lys His Arg Asn Met Val Val Lys Ala Cys Gly 
385                 390                 395                 400 


Cys His 
        


<210> 4278
<211> 402
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<400> 4278
Met Xaa Ala Leu Pro Gly Pro Leu Trp Leu Leu Gly Leu Ala Leu Cys 
1               5                   10                  15      


Ala Leu Gly Gly Gly Gly Pro Gly Leu Arg Pro Pro Pro Gly Cys Pro 
            20                  25                  30          


Gln Arg Arg Leu Gly Ala Arg Glu Arg Arg Asp Val Gln Arg Glu Ile 
        35                  40                  45              


Leu Ala Val Leu Gly Leu Pro Gly Arg Pro Arg Pro Arg Ala Pro Pro 
    50                  55                  60                  


Ala Ala Ser Arg Leu Pro Ala Ser Ala Pro Leu Phe Met Leu Asp Leu 
65                  70                  75                  80  


Tyr His Ala Met Ala Gly Asp Asp Asp Glu Asp Gly Ala Pro Ala Glu 
                85                  90                  95      


Arg Arg Leu Gly Arg Ala Asp Leu Val Met Ser Phe Val Asn Met Val 
            100                 105                 110         


Glu Arg Asp Arg Ala Leu Gly His Gln Glu Pro His Trp Lys Glu Phe 
        115                 120                 125             


Arg Phe Asp Leu Xaa Gln Ile Pro Ala Gly Glu Ala Val Xaa Ala Ala 
    130                 135                 140                 


Glu Phe Arg Ile Tyr Lys Val Pro Ser Ile His Leu Leu Asn Arg Xaa 
145                 150                 155                 160 


Leu His Val Ser Met Phe Gln Val Val Gln Glu Gln Ser Asn Arg Glu 
                165                 170                 175     


Ser Asp Leu Phe Phe Leu Asp Leu Gln Xaa Leu Arg Ala Gly Asp Glu 
            180                 185                 190         


Gly Trp Leu Val Leu Asp Val Xaa Ala Ala Ser Asp Cys Trp Leu Leu 
        195                 200                 205             


Lys Arg His Lys Asp Leu Gly Leu Arg Leu Tyr Val Glu Xaa Glu Asp 
    210                 215                 220                 


Gly His Ser Val Asp Pro Gly Leu Ala Gly Leu Leu Gly Gln Arg Ala 
225                 230                 235                 240 


Pro Arg Ser Gln Gln Pro Phe Val Val Xaa Phe Phe Arg Ala Ser Pro 
                245                 250                 255     


Ser Pro Ile Arg Xaa Pro Arg Ala Val Arg Pro Leu Arg Arg Arg Gln 
            260                 265                 270         


Pro Lys Lys Ser Asn Glu Leu Pro Gln Ala Asn Arg Leu Pro Gly Ile 
        275                 280                 285             


Phe Asp Asp Val His Gly Ser His Gly Arg Gln Val Cys Arg Arg His 
    290                 295                 300                 


Glu Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Leu Asp Trp Val Ile 
305                 310                 315                 320 


Ala Pro Gln Gly Tyr Ser Ala Tyr Tyr Cys Glu Gly Glu Cys Ser Phe 
                325                 330                 335     


Pro Leu Asp Ser Cys Met Asn Ala Xaa Asn His Ala Ile Leu Gln Ser 
            340                 345                 350         


Leu Val His Leu Met Met Pro Asp Ala Val Pro Lys Ala Cys Cys Ala 
        355                 360                 365             


Pro Xaa Lys Leu Ser Ala Xaa Ser Val Leu Tyr Tyr Asp Ser Ser Asn 
    370                 375                 380                 


Asn Val Ile Leu Arg Lys His Arg Asn Met Val Val Lys Ala Cys Gly 
385                 390                 395                 400 


Cys His 
        


<210> 4279
<211> 90
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<400> 4279
Met Leu Trp Phe Ser Gly Val Gly Ala Leu Ala Glu Arg Tyr Cys Arg 
1               5                   10                  15      


Arg Ser Pro Gly Ile Xaa Cys Cys Val Leu Leu Leu Leu Asn Cys Ser 
            20                  25                  30          


Gly Val Pro Met Ser Leu Ala Ser Ser Phe Leu Xaa Gly Ser Val Ala 
        35                  40                  45              


Lys Cys Glu Asn Glu Gly Glu Val Leu Gln Ile Pro Phe Ile Xaa Asp 
    50                  55                  60                  


Asn Pro Cys Ile Met Cys Val Cys Leu His Glu Pro Xaa Arg Trp Ser 
65                  70                  75                  80  


Asn Leu Xaa Gln Asn Pro Gly Phe Tyr Asp 
                85                  90  


<210> 4280
<211> 685
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<400> 4280
Met Leu Trp Phe Ser Gly Val Gly Ala Leu Ala Glu Arg Tyr Cys Arg 
1               5                   10                  15      


Arg Ser Pro Gly Ile Xaa Cys Cys Val Leu Leu Leu Leu Asn Cys Ser 
            20                  25                  30          


Gly Val Pro Met Ser Leu Ala Ser Ser Phe Leu Xaa Gly Ser Val Ala 
        35                  40                  45              


Lys Cys Glu Asn Glu Gly Glu Val Leu Gln Ile Pro Phe Ile Xaa Asp 
    50                  55                  60                  


Asn Pro Cys Ile Met Cys Val Cys Leu Asn Lys Glu Val Xaa Cys Lys 
65                  70                  75                  80  


Arg Glu Lys Cys Pro Val Leu Ser Arg Asp Cys Ala Leu Ala Ile Lys 
                85                  90                  95      


Gln Arg Gly Ala Cys Cys Glu Gln Cys Lys Gly Cys Xaa Tyr Glu Gly 
            100                 105                 110         


Asn Xaa Tyr Asn Ser Ser Phe Lys Trp Gln Ser Pro Ala Glu Pro Cys 
        115                 120                 125             


Val Leu Arg Gln Cys Gln Glu Gly Val Val Xaa Glu Ser Gly Val Arg 
    130                 135                 140                 


Cys Val Val His Cys Lys Asn Pro Leu Glu His Leu Gly Met Cys Cys 
145                 150                 155                 160 


Pro Xaa Cys Pro Gly Cys Val Phe Glu Gly Val Gln Tyr Gln Glu Gly 
                165                 170                 175     


Glu Glu Phe Gln Pro Glu Gly Ser Lys Cys Xaa Lys Cys Ser Cys Xaa 
            180                 185                 190         


Gly Gly Arg Xaa Gln Cys Val Arg Glu Val Cys Pro Ile Leu Ser Cys 
        195                 200                 205             


Pro Gln His Leu Ser His Ile Pro Pro Gly Gln Cys Cys Pro Lys Cys 
    210                 215                 220                 


Leu Gly Gln Arg Lys Val Phe Asp Leu Pro Phe Gly Ser Cys Leu Phe 
225                 230                 235                 240 


Arg Ser Asp Val Tyr Asp Asn Gly Ser Ser Phe Leu Tyr Asp Asn Cys 
                245                 250                 255     


Xaa Ala Cys Xaa Cys Arg Asp Ser Xaa Val Val Cys Lys Arg Lys Cys 
            260                 265                 270         


Ser His Pro Gly Gly Cys Asp Gln Gly Gln Glu Gly Cys Cys Glu Glu 
        275                 280                 285             


Cys Leu Leu Arg Val Pro Pro Glu Asp Ile Lys Val Cys Lys Phe Gly 
    290                 295                 300                 


Asn Lys Ile Phe Gln Asp Gly Glu Met Trp Ser Ser Ile Asn Cys Xaa 
305                 310                 315                 320 


Ile Cys Ala Cys Val Lys Gly Arg Xaa Glu Cys Arg Asn Lys Gln Cys 
                325                 330                 335     


Ile Pro Ile Ser Ser Cys Pro Gln Gly Lys Ile Leu Asn Arg Lys Gly 
            340                 345                 350         


Cys Cys Pro Ile Cys Xaa Glu Lys Pro Gly Val Cys Xaa Val Phe Gly 
        355                 360                 365             


Asp Pro His Tyr Asn Xaa Phe Asp Gly Arg Xaa Phe Asn Phe Gln Gly 
    370                 375                 380                 


Xaa Cys Gln Tyr Val Leu Xaa Lys Asp Cys Ser Ser Pro Ala Ser Pro 
385                 390                 395                 400 


Phe Gln Val Leu Val Lys Asn Asp Ala Arg Arg Xaa Arg Ser Phe Ser 
                405                 410                 415     


Trp Xaa Lys Ser Val Glu Leu Val Leu Gly Glu Ser Arg Val Ser Leu 
            420                 425                 430         


Gln Gln His Leu Xaa Val Arg Trp Asn Gly Ser Arg Ile Ala Leu Pro 
        435                 440                 445             


Cys Arg Ala Pro His Phe His Ile Asp Leu Asp Gly Tyr Leu Leu Lys 
    450                 455                 460                 


Val Xaa Xaa Lys Ala Gly Leu Glu Ile Ser Trp Asp Gly Asp Ser Phe 
465                 470                 475                 480 


Val Glu Val Met Ala Ala Pro His Leu Lys Gly Lys Leu Cys Gly Leu 
                485                 490                 495     


Cys Gly Asn Tyr Asn Gly His Lys Arg Asp Asp Leu Ile Gly Gly Asp 
            500                 505                 510         


Gly Asn Phe Lys Phe Asp Val Asp Asp Phe Ala Glu Ser Trp Arg Val 
        515                 520                 525             


Glu Ser Asn Glu Phe Cys Asn Arg Pro Gln Arg Lys Pro Val Pro Glu 
    530                 535                 540                 


Leu Cys Gln Gly Xaa Val Lys Val Lys Leu Arg Ala His Arg Glu Cys 
545                 550                 555                 560 


Gln Lys Leu Lys Ser Trp Glu Phe Gln Xaa Cys His Ser Xaa Val Asp 
                565                 570                 575     


Tyr Ala Xaa Phe Tyr Arg Ser Cys Val Xaa Asp Met Cys Glu Cys Pro 
            580                 585                 590         


Val His Lys Asn Cys Tyr Cys Glu Ser Phe Leu Ala Tyr Xaa Arg Ala 
        595                 600                 605             


Cys Gln Arg Glu Gly Ile Lys Val His Trp Glu Pro Gln Gln Asn Cys 
    610                 615                 620                 


Ala Ala Xaa Gln Cys Lys His Gly Ala Val Tyr Asp Xaa Cys Gly Pro 
625                 630                 635                 640 


Gly Cys Ile Lys Xaa Cys Asp Asn Trp Asn Glu Ile Gly Pro Cys Asn 
                645                 650                 655     


Lys Pro Cys Val Ala Gly Cys His Cys Pro Ala Asn Leu Val Leu His 
            660                 665                 670         


Lys Gly Arg Cys Ile Lys Pro Val Leu Cys Pro Gln Arg 
        675                 680                 685 


<210> 4281
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<400> 4281
Met Leu Trp Phe Ser Gly Val Gly Ala Leu Ala Glu Arg Tyr Cys Arg 
1               5                   10                  15      


Arg Ser Pro Gly Ile Xaa Cys Cys Val Leu Leu Leu Leu Asn Cys Ser 
            20                  25                  30          


Gly Val Pro Met Ser Leu Ala Ser Ser Phe Leu Xaa Gly Ser Val Ala 
        35                  40                  45              


Lys Cys Glu Asn Glu Gly Glu Val Leu Gln Ile Pro Phe Ile Xaa Asp 
    50                  55                  60                  


Asn Pro Cys Ile Met Cys Val Cys Leu Asn Lys Glu Val Xaa Cys Lys 
65                  70                  75                  80  


Arg Glu Lys Cys Pro Val Leu Ser Arg Asp Cys Ala Leu Ala Ile Lys 
                85                  90                  95      


Gln Arg Gly Ala Cys Cys Glu Gln Cys Lys Val Leu Val Ser Arg Val 
            100                 105                 110         


Leu Arg Asp Xaa Val Leu Phe Xaa Leu Lys Tyr Trp Arg Leu Pro Val 
        115                 120                 125             


Phe Trp Leu His Leu 
    130             


<210> 4282
<211> 161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<400> 4282
Met Leu Trp Phe Ser Gly Val Gly Ala Leu Ala Glu Arg Tyr Cys Arg 
1               5                   10                  15      


Arg Ser Pro Gly Ile Xaa Cys Cys Val Leu Leu Leu Leu Asn Cys Ser 
            20                  25                  30          


Gly Val Pro Met Ser Leu Ala Ser Ser Phe Leu Xaa Gly Ser Val Ala 
        35                  40                  45              


Lys Cys Glu Asn Glu Gly Glu Val Leu Gln Ile Pro Phe Ile Xaa Asp 
    50                  55                  60                  


Asn Pro Cys Ile Met Cys Val Cys Leu Val Ala Pro Met Lys Glu Ile 
65                  70                  75                  80  


Pro Ile Xaa Ala Pro Ser Asn Gly Arg Ala Arg Leu Ser Leu Val Phe 
                85                  90                  95      


Tyr Ala Ser Ala Arg Arg Ala Leu Ser Gln Ser Leu Gly Cys Ala Val 
            100                 105                 110         


Leu Phe Ile Val Lys Xaa Leu Trp Ser Ile Trp Glu Cys Ala Ala Pro 
        115                 120                 125             


His Val Gln Ala Val Cys Leu Arg Val Cys Ser Ile Lys Lys Gly Arg 
    130                 135                 140                 


Asn Phe Ser Gln Lys Glu Ala Asn Val Pro Ser Val Pro Ala Leu Glu 
145                 150                 155                 160 


Ala 
    


<210> 4283
<211> 41
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<400> 4283
Met Pro Gln Leu Tyr Ile Tyr Ile Arg Leu Leu Gly Ala Tyr Leu Phe 
1               5                   10                  15      


Ile Ile Ser Arg Val Gln Gly Gln Asn Leu Asp Ser Met Leu His Gly 
            20                  25                  30          


Xaa Gly Met Lys Ser Asp Ser Asp Gln 
        35                  40      


<210> 4284
<211> 532
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<400> 4284
Met Pro Gln Leu Tyr Ile Tyr Ile Arg Leu Leu Gly Ala Tyr Leu Phe 
1               5                   10                  15      


Ile Ile Ser Arg Val Gln Gly Gln Asn Leu Asp Ser Met Leu His Gly 
            20                  25                  30          


Xaa Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser Glu Asn Gly Val 
        35                  40                  45              


Xaa Leu Ala Pro Glu Asp Xaa Leu Pro Phe Leu Lys Cys Tyr Cys Ser 
    50                  55                  60                  


Gly His Cys Pro Asp Asp Ala Ile Asn Asn Xaa Cys Ile Xaa Asn Gly 
65                  70                  75                  80  


His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu Xaa Xaa Leu 
                85                  90                  95      


Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln Cys Lys Asp 
            100                 105                 110         


Ser Pro Lys Ala Gln Leu Arg Arg Xaa Ile Glu Cys Cys Arg Xaa Asn 
        115                 120                 125             


Leu Cys Asn Gln Tyr Leu Gln Pro Xaa Leu Pro Pro Val Val Ile Gly 
    130                 135                 140                 


Pro Phe Phe Asp Gly Ser Ile Arg Trp Leu Val Leu Leu Ile Ser Met 
145                 150                 155                 160 


Ala Val Cys Ile Ile Ala Met Ile Ile Phe Ser Ser Cys Phe Cys Tyr 
                165                 170                 175     


Lys His Tyr Cys Lys Ser Ile Ser Ser Arg Arg Arg Tyr Asn Arg Asp 
            180                 185                 190         


Leu Glu Gln Asp Glu Ala Phe Ile Pro Val Gly Glu Ser Leu Lys Asp 
        195                 200                 205             


Leu Ile Asp Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu Pro Leu 
    210                 215                 220                 


Leu Val Gln Arg Xaa Ile Ala Lys Gln Ile Gln Met Val Arg Gln Val 
225                 230                 235                 240 


Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg Gly Glu 
                245                 250                 255     


Lys Val Ala Val Lys Val Phe Phe Xaa Xaa Glu Glu Ala Ser Trp Phe 
            260                 265                 270         


Arg Glu Xaa Glu Ile Tyr Gln Xaa Val Leu Met Arg His Glu Asn Ile 
        275                 280                 285             


Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Xaa Gly Ser Trp Xaa Gln 
    290                 295                 300                 


Leu Tyr Leu Ile Xaa Asp Tyr His Glu Asn Gly Ser Leu Tyr Asp Phe 
305                 310                 315                 320 


Leu Lys Cys Ala Xaa Leu Asp Xaa Arg Ala Leu Leu Lys Leu Ala Tyr 
                325                 330                 335     


Ser Ala Ala Cys Gly Leu Cys His Leu His Xaa Glu Ile Tyr Gly Xaa 
            340                 345                 350         


Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile 
        355                 360                 365             


Leu Ile Lys Lys Asn Gly Ser Cys Cys Ile Ala Asp Leu Gly Leu Ala 
    370                 375                 380                 


Val Lys Phe Asn Ser Asp Xaa Asn Glu Val Asp Val Pro Leu Asn Xaa 
385                 390                 395                 400 


Arg Val Gly Xaa Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Ser 
                405                 410                 415     


Leu Asn Lys Asn His Phe Gln Pro Tyr Ile Met Ala Asp Ile Tyr Ser 
            420                 425                 430         


Phe Gly Leu Ile Ile Trp Glu Met Ala Arg Arg Cys Ile Xaa Gly Gly 
        435                 440                 445             


Ile Val Glu Glu Tyr Gln Leu Pro Tyr Tyr Asn Met Val Pro Ser Asp 
    450                 455                 460                 


Pro Ser Tyr Glu Asp Met Arg Glu Val Val Cys Val Lys Arg Leu Arg 
465                 470                 475                 480 


Pro Ile Val Ser Asn Arg Trp Asn Ser Asp Glu Cys Leu Arg Ala Val 
                485                 490                 495     


Leu Lys Leu Met Ser Glu Cys Trp Ala His Asn Pro Ala Ser Arg Leu 
            500                 505                 510         


Xaa Ala Leu Arg Ile Lys Lys Xaa Leu Ala Lys Met Val Glu Ser Gln 
        515                 520                 525             


Asp Val Lys Ile 
    530         


<210> 4285
<211> 532
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<400> 4285
Met Gly Trp Leu Glu Glu Leu Asn Trp Gln Leu His Ile Phe Leu Leu 
1               5                   10                  15      


Ile Leu Leu Ser Met His Xaa Arg Ala Asn Phe Leu Asp Asn Met Leu 
            20                  25                  30          


Leu Arg Ser Ala Gly Lys Leu Asn Val Gly Xaa Lys Lys Glu Asp Gly 
        35                  40                  45              


Glu Ser Xaa Ala Pro Xaa Pro Arg Pro Lys Val Leu Arg Cys Lys Cys 
    50                  55                  60                  


His His His Cys Pro Glu Asp Ser Val Asn Asn Ile Cys Ser Xaa Asp 
65                  70                  75                  80  


Gly Tyr Cys Phe Xaa Met Ile Glu Glu Asp Asp Ser Gly Leu Pro Val 
                85                  90                  95      


Val Xaa Ser Gly Cys Leu Gly Leu Glu Gly Ser Asp Phe Gln Cys Arg 
            100                 105                 110         


Asp Xaa Pro Ile Pro His Gln Arg Arg Ser Ile Glu Cys Cys Xaa Glu 
        115                 120                 125             


Arg Asn Glu Cys Asn Lys Asp Leu His Pro Xaa Leu Pro Pro Leu Lys 
    130                 135                 140                 


Asn Arg Asp Phe Val Asp Gly Pro Ile His His Arg Ala Leu Leu Ile 
145                 150                 155                 160 


Ser Val Xaa Val Cys Ser Leu Leu Leu Val Leu Ile Ile Leu Phe Cys 
                165                 170                 175     


Tyr Phe Arg Tyr Lys Arg Gln Glu Xaa Arg Pro Arg Tyr Ser Ile Gly 
            180                 185                 190         


Leu Glu Gln Asp Glu Xaa Tyr Ile Pro Pro Gly Glu Ser Leu Arg Asp 
        195                 200                 205             


Leu Ile Glu Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu Pro Leu 
    210                 215                 220                 


Leu Val Gln Arg Xaa Ile Ala Lys Gln Ile Gln Met Val Lys Gln Ile 
225                 230                 235                 240 


Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg Gly Glu 
                245                 250                 255     


Lys Val Ala Val Lys Val Phe Phe Xaa Xaa Glu Glu Ala Ser Trp Phe 
            260                 265                 270         


Arg Glu Xaa Glu Ile Tyr Gln Xaa Val Leu Met Arg His Glu Asn Ile 
        275                 280                 285             


Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Xaa Gly Ser Trp Xaa Gln 
    290                 295                 300                 


Leu Tyr Leu Ile Xaa Asp Tyr His Glu Asn Gly Ser Leu Tyr Asp Tyr 
305                 310                 315                 320 


Leu Lys Ser Xaa Xaa Leu Asp Ala Lys Ser Met Leu Lys Leu Ala Tyr 
                325                 330                 335     


Ser Ser Val Ser Gly Leu Cys His Leu His Xaa Glu Ile Phe Ser Xaa 
            340                 345                 350         


Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile 
        355                 360                 365             


Leu Val Lys Lys Asn Gly Xaa Cys Cys Ile Ala Asp Leu Gly Leu Ala 
    370                 375                 380                 


Val Lys Phe Ile Ser Asp Xaa Asn Glu Val Asp Ile Pro Pro Asn Xaa 
385                 390                 395                 400 


Arg Val Gly Xaa Lys Arg Tyr Met Pro Pro Glu Val Leu Asp Glu Ser 
                405                 410                 415     


Leu Asn Arg Asn His Phe Gln Ser Tyr Ile Met Ala Asp Met Tyr Ser 
            420                 425                 430         


Phe Gly Leu Ile Leu Trp Glu Val Ala Arg Arg Cys Val Ser Gly Gly 
        435                 440                 445             


Ile Val Glu Glu Tyr Gln Leu Pro Tyr His Asp Leu Val Pro Ser Asp 
    450                 455                 460                 


Pro Ser Tyr Glu Asp Met Arg Glu Ile Val Cys Ile Lys Lys Leu Arg 
465                 470                 475                 480 


Pro Ser Phe Pro Asn Arg Trp Ser Ser Asp Glu Cys Leu Arg Gln Met 
                485                 490                 495     


Gly Lys Leu Met Xaa Glu Cys Trp Ala His Asn Pro Ala Ser Arg Leu 
            500                 505                 510         


Xaa Ala Leu Arg Val Lys Lys Xaa Leu Ala Lys Met Ser Glu Ser Gln 
        515                 520                 525             


Asp Ile Lys Leu 
    530         


<210> 4286
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<400> 4286
Met Leu Leu Arg Ser Ala Gly Lys Leu Asn Val Gly Xaa Lys Lys Glu 
1               5                   10                  15      


Asp Gly Glu Ser Xaa Ala Pro Xaa Pro Arg Pro Lys Val Leu Arg Cys 
            20                  25                  30          


Lys Cys His His His Cys Pro Glu Asp Ser Val Asn Asn Ile Cys Ser 
        35                  40                  45              


Xaa Asp Gly Tyr Cys Phe Xaa Met Ile Glu Glu Asp Asp Ser Gly Leu 
    50                  55                  60                  


Pro Val Val Xaa Ser Gly Cys Leu Gly Leu Glu Gly Ser Asp Phe Gln 
65                  70                  75                  80  


Cys Arg Asp Xaa Pro Ile Pro His Gln Arg Arg Ser Ile Glu Cys Cys 
                85                  90                  95      


Xaa Glu Arg Asn Glu Cys Asn Lys Asp Leu His Pro Xaa Leu Pro Pro 
            100                 105                 110         


Leu Lys Asn Arg Asp Phe Val Asp Gly Pro Ile His His 
        115                 120                 125 


<210> 4287
<211> 502
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<400> 4287
Met Leu Leu Arg Ser Ala Gly Lys Leu Asn Val Gly Xaa Lys Lys Glu 
1               5                   10                  15      


Asp Gly Glu Ser Xaa Ala Pro Xaa Pro Arg Pro Lys Val Leu Arg Cys 
            20                  25                  30          


Lys Cys His His His Cys Pro Glu Asp Ser Val Asn Asn Ile Cys Ser 
        35                  40                  45              


Xaa Asp Gly Tyr Cys Phe Xaa Met Ile Glu Glu Asp Asp Ser Gly Leu 
    50                  55                  60                  


Pro Val Val Xaa Ser Gly Cys Leu Gly Leu Glu Gly Ser Asp Phe Gln 
65                  70                  75                  80  


Cys Arg Asp Xaa Pro Ile Pro His Gln Arg Arg Ser Ile Glu Cys Cys 
                85                  90                  95      


Xaa Glu Arg Asn Glu Cys Asn Lys Asp Leu His Pro Xaa Leu Pro Pro 
            100                 105                 110         


Leu Lys Asn Arg Asp Phe Val Asp Gly Pro Ile His His Arg Ala Leu 
        115                 120                 125             


Leu Ile Ser Val Xaa Val Cys Ser Leu Leu Leu Val Leu Ile Ile Leu 
    130                 135                 140                 


Phe Cys Tyr Phe Arg Tyr Lys Arg Gln Glu Xaa Arg Pro Arg Tyr Ser 
145                 150                 155                 160 


Ile Gly Leu Glu Gln Asp Glu Xaa Tyr Ile Pro Pro Gly Glu Ser Leu 
                165                 170                 175     


Arg Asp Leu Ile Glu Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu 
            180                 185                 190         


Pro Leu Leu Val Gln Arg Xaa Ile Ala Lys Gln Ile Gln Met Val Lys 
        195                 200                 205             


Gln Ile Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg 
    210                 215                 220                 


Gly Glu Lys Val Ala Val Lys Val Phe Phe Xaa Xaa Glu Glu Ala Ser 
225                 230                 235                 240 


Trp Phe Arg Glu Xaa Glu Ile Tyr Gln Xaa Val Leu Met Arg His Glu 
                245                 250                 255     


Asn Ile Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Xaa Gly Ser Trp 
            260                 265                 270         


Xaa Gln Leu Tyr Leu Ile Xaa Asp Tyr His Glu Asn Gly Ser Leu Tyr 
        275                 280                 285             


Asp Tyr Leu Lys Ser Xaa Xaa Leu Asp Ala Lys Ser Met Leu Lys Leu 
    290                 295                 300                 


Ala Tyr Ser Ser Val Ser Gly Leu Cys His Leu His Xaa Glu Ile Phe 
305                 310                 315                 320 


Ser Xaa Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys 
                325                 330                 335     


Asn Ile Leu Val Lys Lys Asn Gly Xaa Cys Cys Ile Ala Asp Leu Gly 
            340                 345                 350         


Leu Ala Val Lys Phe Ile Ser Asp Xaa Asn Glu Val Asp Ile Pro Pro 
        355                 360                 365             


Asn Xaa Arg Val Gly Xaa Lys Arg Tyr Met Pro Pro Glu Val Leu Asp 
    370                 375                 380                 


Glu Ser Leu Asn Arg Asn His Phe Gln Ser Tyr Ile Met Ala Asp Met 
385                 390                 395                 400 


Tyr Ser Phe Gly Leu Ile Leu Trp Glu Val Ala Arg Arg Cys Val Ser 
                405                 410                 415     


Gly Gly Ile Val Glu Glu Tyr Gln Leu Pro Tyr His Asp Leu Val Pro 
            420                 425                 430         


Ser Asp Pro Ser Tyr Glu Asp Met Arg Glu Ile Val Cys Ile Lys Lys 
        435                 440                 445             


Leu Arg Pro Ser Phe Pro Asn Arg Trp Ser Ser Asp Glu Cys Leu Arg 
    450                 455                 460                 


Gln Met Gly Lys Leu Met Xaa Glu Cys Trp Ala His Asn Pro Ala Ser 
465                 470                 475                 480 


Arg Leu Xaa Ala Leu Arg Val Lys Lys Xaa Leu Ala Lys Met Ser Glu 
                485                 490                 495     


Ser Gln Asp Ile Lys Leu 
            500         


<210> 4288
<211> 114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<400> 4288
Met Leu Leu Arg Ser Ala Gly Lys Leu Asn Val Gly Xaa Lys Lys Glu 
1               5                   10                  15      


Asp Gly Glu Ser Xaa Ala Pro Xaa Pro Arg Pro Lys Val Leu Arg Cys 
            20                  25                  30          


Lys Cys His His His Cys Pro Glu Asp Ser Val Asn Asn Ile Cys Ser 
        35                  40                  45              


Xaa Asp Gly Tyr Cys Phe Xaa Met Ile Glu Glu Asp Asp Ser Gly Leu 
    50                  55                  60                  


Pro Val Val Xaa Ser Gly Cys Leu Gly Leu Glu Gly Ser Asp Phe Gln 
65                  70                  75                  80  


Cys Arg Val Arg Xaa Leu Pro Phe Leu Ile Lys Glu Asp Gln Leu Asn 
                85                  90                  95      


Ala Ala Gln Lys Gly Xaa Asn Val Ile Lys Xaa Tyr Xaa Leu His Cys 
            100                 105                 110         


Leu His 
        


<210> 4289
<211> 530
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<400> 4289
Met Xaa Ser Ser Leu Gln Arg Pro Trp Arg Val Pro Trp Leu Pro Trp 
1               5                   10                  15      


Xaa Ile Leu Leu Val Ser Xaa Ala Ala Ala Ser Gln Asn Gln Glu Arg 
            20                  25                  30          


Leu Cys Ala Phe Lys Asp Pro Tyr Gln Gln Asp Leu Gly Ile Gly Glu 
        35                  40                  45              


Ser Arg Ile Ser His Glu Asn Gly Xaa Ile Leu Cys Ser Lys Gly Ser 
    50                  55                  60                  


Xaa Cys Tyr Gly Leu Trp Glu Lys Ser Lys Gly Asp Ile Asn Leu Val 
65                  70                  75                  80  


Lys Gln Gly Cys Trp Ser His Ile Gly Asp Pro Gln Glu Cys His Tyr 
                85                  90                  95      


Glu Glu Cys Val Val Xaa Xaa Xaa Pro Pro Ser Ile Gln Asn Gly Xaa 
            100                 105                 110         


Tyr Arg Phe Cys Cys Cys Ser Xaa Asp Leu Cys Asn Val Asn Phe Xaa 
        115                 120                 125             


Glu Asn Phe Pro Pro Pro Asp Xaa Xaa Pro Leu Ser Pro Pro His Ser 
    130                 135                 140                 


Phe Asn Arg Asp Glu Xaa Ile Ile Ile Ala Leu Ala Ser Val Ser Val 
145                 150                 155                 160 


Leu Ala Val Leu Ile Val Ala Leu Cys Phe Gly Tyr Arg Met Leu Xaa 
                165                 170                 175     


Gly Asp Arg Lys Gln Gly Leu His Ser Met Asn Met Met Glu Ala Ala 
            180                 185                 190         


Ala Ser Glu Pro Ser Leu Asp Leu Asp Asn Leu Lys Leu Leu Glu Leu 
        195                 200                 205             


Ile Gly Arg Gly Arg Tyr Gly Ala Val Tyr Lys Gly Ser Leu Asp Glu 
    210                 215                 220                 


Arg Pro Val Ala Val Lys Val Phe Ser Phe Ala Asn Arg Gln Asn Phe 
225                 230                 235                 240 


Ile Asn Glu Lys Asn Ile Tyr Arg Val Pro Leu Met Glu His Asp Asn 
                245                 250                 255     


Ile Ala Arg Phe Ile Val Gly Asp Glu Arg Val Xaa Ala Asp Gly Arg 
            260                 265                 270         


Met Glu Tyr Leu Leu Val Met Glu Tyr Tyr Pro Asn Gly Ser Leu Cys 
        275                 280                 285             


Lys Tyr Leu Ser Leu His Xaa Ser Asp Trp Val Ser Ser Cys Arg Leu 
    290                 295                 300                 


Ala His Ser Val Xaa Arg Gly Leu Ala Tyr Leu His Xaa Glu Leu Pro 
305                 310                 315                 320 


Arg Gly Asp His Tyr Lys Pro Ala Ile Ser His Arg Asp Leu Asn Ser 
                325                 330                 335     


Arg Asn Val Leu Val Lys Asn Asp Gly Xaa Cys Val Ile Ser Asp Phe 
            340                 345                 350         


Gly Leu Ser Met Arg Leu Xaa Gly Asn Arg Leu Val Arg Pro Gly Glu 
        355                 360                 365             


Glu Asp Asn Ala Ala Ile Ser Glu Val Gly Xaa Ile Arg Tyr Met Ala 
    370                 375                 380                 


Pro Glu Val Leu Glu Gly Ala Val Asn Leu Arg Asp Cys Glu Ser Ala 
385                 390                 395                 400 


Leu Lys Gln Val Asp Met Tyr Ala Leu Gly Leu Ile Tyr Trp Glu Ile 
                405                 410                 415     


Phe Met Arg Cys Xaa Asp Leu Phe Pro Gly Glu Ser Val Pro Glu Tyr 
            420                 425                 430         


Gln Met Ala Phe Gln Xaa Glu Val Gly Asn His Pro Xaa Phe Glu Asp 
        435                 440                 445             


Met Gln Val Leu Val Ser Arg Glu Lys Gln Arg Pro Lys Phe Pro Glu 
    450                 455                 460                 


Ala Trp Lys Glu Asn Ser Leu Ala Val Arg Ser Leu Lys Glu Xaa Ile 
465                 470                 475                 480 


Glu Asp Cys Trp Asp Gln Asp Ala Glu Ala Arg Leu Xaa Ala Gln Cys 
                485                 490                 495     


Ala Glu Glu Arg Met Ala Glu Leu Met Met Ile Trp Glu Arg Asn Lys 
            500                 505                 510         


Ser Val Ser Pro Xaa Val Asn Pro Met Ser Xaa Ala Met Gln Asn Glu 
        515                 520                 525             


Arg Arg 
    530 


<210> 4290
<211> 1038
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1027)
<223> Selenocysteine

<400> 4290
Met Xaa Ser Ser Leu Gln Arg Pro Trp Arg Val Pro Trp Leu Pro Trp 
1               5                   10                  15      


Xaa Ile Leu Leu Val Ser Xaa Ala Ala Ala Ser Gln Asn Gln Glu Arg 
            20                  25                  30          


Leu Cys Ala Phe Lys Asp Pro Tyr Gln Gln Asp Leu Gly Ile Gly Glu 
        35                  40                  45              


Ser Arg Ile Ser His Glu Asn Gly Xaa Ile Leu Cys Ser Lys Gly Ser 
    50                  55                  60                  


Xaa Cys Tyr Gly Leu Trp Glu Lys Ser Lys Gly Asp Ile Asn Leu Val 
65                  70                  75                  80  


Lys Gln Gly Cys Trp Ser His Ile Gly Asp Pro Gln Glu Cys His Tyr 
                85                  90                  95      


Glu Glu Cys Val Val Xaa Xaa Xaa Pro Pro Ser Ile Gln Asn Gly Xaa 
            100                 105                 110         


Tyr Arg Phe Cys Cys Cys Ser Xaa Asp Leu Cys Asn Val Asn Phe Xaa 
        115                 120                 125             


Glu Asn Phe Pro Pro Pro Asp Xaa Xaa Pro Leu Ser Pro Pro His Ser 
    130                 135                 140                 


Phe Asn Arg Asp Glu Xaa Ile Ile Ile Ala Leu Ala Ser Val Ser Val 
145                 150                 155                 160 


Leu Ala Val Leu Ile Val Ala Leu Cys Phe Gly Tyr Arg Met Leu Xaa 
                165                 170                 175     


Gly Asp Arg Lys Gln Gly Leu His Ser Met Asn Met Met Glu Ala Ala 
            180                 185                 190         


Ala Ser Glu Pro Ser Leu Asp Leu Asp Asn Leu Lys Leu Leu Glu Leu 
        195                 200                 205             


Ile Gly Arg Gly Arg Tyr Gly Ala Val Tyr Lys Gly Ser Leu Asp Glu 
    210                 215                 220                 


Arg Pro Val Ala Val Lys Val Phe Ser Phe Ala Asn Arg Gln Asn Phe 
225                 230                 235                 240 


Ile Asn Glu Lys Asn Ile Tyr Arg Val Pro Leu Met Glu His Asp Asn 
                245                 250                 255     


Ile Ala Arg Phe Ile Val Gly Asp Glu Arg Val Xaa Ala Asp Gly Arg 
            260                 265                 270         


Met Glu Tyr Leu Leu Val Met Glu Tyr Tyr Pro Asn Gly Ser Leu Cys 
        275                 280                 285             


Lys Tyr Leu Ser Leu His Xaa Ser Asp Trp Val Ser Ser Cys Arg Leu 
    290                 295                 300                 


Ala His Ser Val Xaa Arg Gly Leu Ala Tyr Leu His Xaa Glu Leu Pro 
305                 310                 315                 320 


Arg Gly Asp His Tyr Lys Pro Ala Ile Ser His Arg Asp Leu Asn Ser 
                325                 330                 335     


Arg Asn Val Leu Val Lys Asn Asp Gly Xaa Cys Val Ile Ser Asp Phe 
            340                 345                 350         


Gly Leu Ser Met Arg Leu Xaa Gly Asn Arg Leu Val Arg Pro Gly Glu 
        355                 360                 365             


Glu Asp Asn Ala Ala Ile Ser Glu Val Gly Xaa Ile Arg Tyr Met Ala 
    370                 375                 380                 


Pro Glu Val Leu Glu Gly Ala Val Asn Leu Arg Asp Cys Glu Ser Ala 
385                 390                 395                 400 


Leu Lys Gln Val Asp Met Tyr Ala Leu Gly Leu Ile Tyr Trp Glu Ile 
                405                 410                 415     


Phe Met Arg Cys Xaa Asp Leu Phe Pro Gly Glu Ser Val Pro Glu Tyr 
            420                 425                 430         


Gln Met Ala Phe Gln Xaa Glu Val Gly Asn His Pro Xaa Phe Glu Asp 
        435                 440                 445             


Met Gln Val Leu Val Ser Arg Glu Lys Gln Arg Pro Lys Phe Pro Glu 
    450                 455                 460                 


Ala Trp Lys Glu Asn Ser Leu Ala Val Arg Ser Leu Lys Glu Xaa Ile 
465                 470                 475                 480 


Glu Asp Cys Trp Asp Gln Asp Ala Glu Ala Arg Leu Xaa Ala Gln Cys 
                485                 490                 495     


Ala Glu Glu Arg Met Ala Glu Leu Met Met Ile Trp Glu Arg Asn Lys 
            500                 505                 510         


Ser Val Ser Pro Xaa Val Asn Pro Met Ser Xaa Ala Met Gln Asn Glu 
        515                 520                 525             


Arg Asn Leu Ser His Asn Arg Arg Val Pro Lys Ile Gly Pro Tyr Pro 
    530                 535                 540                 


Asp Tyr Ser Ser Ser Ser Tyr Ile Glu Asp Ser Ile His His Xaa Asp 
545                 550                 555                 560 


Ser Ile Val Lys Asn Ile Ser Ser Glu His Ser Met Ser Ser Xaa Pro 
                565                 570                 575     


Leu Xaa Ile Gly Glu Lys Asn Arg Asn Ser Ile Asn Tyr Glu Arg Gln 
            580                 585                 590         


Gln Ala Gln Ala Arg Ile Pro Ser Pro Glu Xaa Ser Val Xaa Ser Leu 
        595                 600                 605             


Ser Xaa Asn Xaa Xaa Xaa Xaa Asn Xaa Xaa Gly Leu Xaa Pro Ser Xaa 
    610                 615                 620                 


Gly Met Xaa Xaa Ile Ser Glu Met Pro Tyr Pro Asp Glu Xaa Asn Leu 
625                 630                 635                 640 


His Xaa Xaa Asn Val Ala Gln Ser Ile Gly Pro Xaa Pro Val Cys Leu 
                645                 650                 655     


Gln Leu Xaa Glu Glu Asp Leu Glu Xaa Asn Lys Leu Asp Pro Lys Glu 
            660                 665                 670         


Val Asp Lys Asn Leu Lys Glu Ser Ser Asp Glu Asn Leu Met Glu His 
        675                 680                 685             


Ser Leu Lys Gln Phe Ser Gly Pro Asp Pro Leu Ser Ser Xaa Ser Ser 
    690                 695                 700                 


Ser Leu Leu Tyr Pro Leu Ile Lys Leu Ala Val Glu Ala Xaa Gly Gln 
705                 710                 715                 720 


Gln Asp Phe Xaa Gln Xaa Ala Asn Gly Gln Ala Cys Leu Ile Pro Asp 
                725                 730                 735     


Val Leu Pro Xaa Gln Ile Tyr Pro Leu Pro Lys Gln Gln Asn Leu Pro 
            740                 745                 750         


Lys Arg Pro Xaa Ser Leu Pro Leu Asn Xaa Lys Asn Ser Xaa Lys Glu 
        755                 760                 765             


Pro Arg Leu Lys Phe Gly Ser Lys His Lys Ser Asn Leu Lys Gln Val 
    770                 775                 780                 


Glu Xaa Gly Val Ala Lys Met Asn Xaa Ile Asn Ala Ala Glu Pro His 
785                 790                 795                 800 


Val Val Xaa Val Xaa Met Asn Gly Val Ala Gly Arg Asn His Ser Val 
                805                 810                 815     


Asn Ser His Ala Ala Xaa Xaa Gln Tyr Ala Asn Gly Xaa Val Leu Ser 
            820                 825                 830         


Gly Gln Xaa Xaa Asn Ile Val Xaa His Arg Ala Gln Glu Met Leu Gln 
        835                 840                 845             


Asn Gln Phe Ile Gly Glu Asp Xaa Arg Leu Asn Ile Asn Ser Ser Pro 
    850                 855                 860                 


Asp Glu His Glu Pro Leu Leu Arg Arg Glu Gln Gln Ala Gly His Asp 
865                 870                 875                 880 


Glu Gly Val Leu Asp Arg Leu Val Asp Arg Arg Glu Arg Pro Leu Glu 
                885                 890                 895     


Gly Gly Arg Xaa Asn Ser Asn Asn Asn Asn Ser Asn Pro Cys Ser Glu 
            900                 905                 910         


Gln Asp Val Leu Ala Gln Gly Val Pro Ser Xaa Ala Ala Asp Pro Gly 
        915                 920                 925             


Pro Ser Lys Pro Arg Arg Ala Gln Arg Pro Asn Ser Leu Asp Leu Ser 
    930                 935                 940                 


Ala Xaa Asn Val Leu Asp Gly Ser Ser Ile Gln Ile Gly Glu Ser Xaa 
945                 950                 955                 960 


Gln Asp Gly Lys Ser Gly Ser Gly Glu Lys Ile Lys Lys Arg Val Lys 
                965                 970                 975     


Xaa Pro Tyr Ser Leu Lys Arg Trp Arg Pro Ser Xaa Trp Val Ile Ser 
            980                 985                 990         


Xaa Glu Ser Leu Asp Cys Glu Val  Asn Asn Asn Gly Ser  Asn Arg Ala 
        995                 1000                 1005             


Val His  Ser Lys Ser Ser Xaa  Ala Val Tyr Leu Ala  Glu Gly Gly 
    1010                 1015                 1020             


Xaa Ala  Xaa Xaa Met Val Ser  Lys Asp Ile Gly Met  Asn Cys Leu 
    1025                 1030                 1035             


<210> 4291
<211> 675
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<400> 4291
Met Asp Xaa Lys Ser Ile Leu Glu Glu Leu Leu Leu Lys Arg Ser Gln 
1               5                   10                  15      


Gln Lys Lys Lys Met Ser Pro Asn Asn Tyr Lys Glu Arg Leu Phe Val 
            20                  25                  30          


Leu Xaa Lys Xaa Asn Leu Ser Tyr Tyr Glu Tyr Asp Lys Met Lys Arg 
        35                  40                  45              


Gly Ser Arg Lys Gly Ser Ile Glu Ile Lys Lys Ile Arg Cys Val Glu 
    50                  55                  60                  


Lys Val Asn Leu Glu Glu Gln Xaa Pro Val Glu Arg Gln Tyr Pro Phe 
65                  70                  75                  80  


Gln Ile Val Tyr Lys Asp Gly Leu Leu Tyr Val Tyr Ala Ser Asn Glu 
                85                  90                  95      


Glu Ser Arg Ser Gln Trp Leu Lys Ala Leu Gln Lys Glu Ile Arg Gly 
            100                 105                 110         


Asn Pro His Leu Leu Val Lys Tyr His Ser Gly Phe Phe Val Asp Gly 
        115                 120                 125             


Lys Phe Leu Cys Cys Gln Gln Ser Cys Lys Ala Ala Pro Gly Cys Xaa 
    130                 135                 140                 


Leu Trp Glu Ala Tyr Ala Asn Leu His Xaa Ala Val Asn Glu Glu Lys 
145                 150                 155                 160 


His Arg Val Pro Xaa Phe Pro Asp Arg Val Leu Lys Ile Pro Arg Ala 
                165                 170                 175     


Val Pro Val Leu Lys Met Asp Ala Pro Ser Ser Ser Xaa Xaa Leu Ala 
            180                 185                 190         


Gln Tyr Asp Asn Glu Ser Lys Lys Asn Tyr Gly Ser Gln Pro Pro Ser 
        195                 200                 205             


Ser Ser Xaa Ser Leu Ala Gln Tyr Asp Ser Asn Ser Lys Lys Ile Tyr 
    210                 215                 220                 


Gly Ser Gln Pro Asn Phe Asn Met Gln Tyr Ile Pro Arg Glu Asp Phe 
225                 230                 235                 240 


Pro Asp Trp Trp Gln Val Arg Lys Leu Lys Ser Ser Ser Ser Ser Glu 
                245                 250                 255     


Asp Val Ala Ser Ser Asn Gln Lys Glu Arg Asn Val Asn His Xaa Xaa 
            260                 265                 270         


Ser Lys Ile Ser Trp Glu Phe Pro Glu Ser Ser Ser Ser Glu Glu Glu 
        275                 280                 285             


Glu Asn Leu Asp Asp Tyr Asp Trp Phe Ala Gly Asn Ile Ser Arg Ser 
    290                 295                 300                 


Gln Ser Glu Gln Leu Leu Arg Gln Lys Gly Lys Glu Gly Ala Phe Met 
305                 310                 315                 320 


Val Arg Asn Ser Ser Gln Val Gly Met Tyr Xaa Val Ser Leu Phe Ser 
                325                 330                 335     


Lys Ala Val Asn Asp Lys Lys Gly Xaa Val Lys His Tyr His Val His 
            340                 345                 350         


Xaa Asn Ala Glu Asn Lys Leu Tyr Leu Ala Glu Asn Tyr Cys Phe Asp 
        355                 360                 365             


Ser Ile Pro Lys Leu Ile His Tyr His Gln His Asn Ser Ala Gly Met 
    370                 375                 380                 


Ile Xaa Arg Leu Arg His Pro Val Ser Xaa Lys Ala Asn Lys Val Pro 
385                 390                 395                 400 


Asp Ser Val Ser Leu Gly Asn Gly Ile Trp Glu Leu Lys Arg Glu Glu 
                405                 410                 415     


Ile Xaa Leu Leu Lys Glu Leu Gly Ser Gly Gln Phe Gly Val Val Gln 
            420                 425                 430         


Leu Gly Lys Trp Lys Gly Gln Tyr Asp Val Ala Val Lys Met Ile Lys 
        435                 440                 445             


Glu Gly Ser Met Ser Glu Asp Glu Phe Phe Gln Glu Ala Gln Xaa Met 
    450                 455                 460                 


Met Lys Leu Ser His Pro Lys Leu Val Lys Phe Tyr Gly Val Cys Ser 
465                 470                 475                 480 


Lys Glu Tyr Pro Ile Tyr Ile Val Xaa Glu Tyr Ile Ser Asn Gly Cys 
                485                 490                 495     


Leu Leu Asn Tyr Leu Arg Ser His Gly Lys Gly Leu Glu Pro Ser Gln 
            500                 505                 510         


Leu Leu Glu Met Cys Tyr Asp Val Cys Glu Gly Met Ala Phe Leu Glu 
        515                 520                 525             


Ser His Gln Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val 
    530                 535                 540                 


Asp Arg Asp Leu Cys Val Lys Val Ser Asp Phe Gly Met Xaa Arg Tyr 
545                 550                 555                 560 


Val Leu Asp Asp Gln Tyr Val Ser Ser Val Gly Xaa Lys Phe Pro Val 
                565                 570                 575     


Lys Trp Ser Ala Pro Glu Val Phe His Tyr Phe Lys Tyr Ser Ser Lys 
            580                 585                 590         


Ser Asp Val Trp Ala Phe Gly Ile Leu Met Trp Glu Val Phe Ser Leu 
        595                 600                 605             


Gly Lys Gln Pro Tyr Asp Leu Tyr Asp Asn Ser Gln Val Val Leu Lys 
    610                 615                 620                 


Val Ser Gln Gly His Arg Leu Tyr Arg Pro His Leu Ala Ser Asp Xaa 
625                 630                 635                 640 


Ile Tyr Gln Ile Met Tyr Ser Cys Trp His Glu Leu Pro Glu Lys Arg 
                645                 650                 655     


Pro Xaa Phe Gln Gln Leu Leu Ser Ser Ile Glu Pro Leu Arg Glu Lys 
            660                 665                 670         


Asp Lys His 
        675 


<210> 4292
<211> 987
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<400> 4292
Met Arg Cys Arg Asn Met Phe Phe Ser Phe Lys Ala Ser Leu Cys Gly 
1               5                   10                  15      


Cys Gly Ala Ala Xaa Ala Pro Ser Leu Xaa Ala Ile Ser Cys Xaa Leu 
            20                  25                  30          


Asn Cys Ser Cys Gln Ser Phe Lys Pro Gly Lys Ile Asn His Arg Gln 
        35                  40                  45              


Cys Asp Gln Cys Lys His Gly Trp Val Ala His Ala Leu Ser Lys Leu 
    50                  55                  60                  


Arg Ile Pro Pro Met Tyr Pro Xaa Ser Gln Val Glu Ile Val Gln Ser 
65                  70                  75                  80  


Asn Val Val Phe Asp Ile Ser Ser Leu Met Leu Tyr Gly Xaa Gln Ala 
                85                  90                  95      


Ile Pro Val Arg Leu Lys Ile Leu Leu Asp Arg Leu Phe Ser Val Leu 
            100                 105                 110         


Lys Gln Asp Glu Val Leu Gln Ile Leu His Ala Leu Asp Trp Xaa Leu 
        115                 120                 125             


Gln Asp Tyr Ile Arg Gly Tyr Val Leu Gln Asp Ala Ser Gly Lys Val 
    130                 135                 140                 


Leu Asp His Trp Ser Ile Met Xaa Ser Glu Glu Glu Val Ala Xaa Leu 
145                 150                 155                 160 


Gln Gln Phe Leu Arg Phe Gly Glu Xaa Lys Ser Ile Val Glu Leu Met 
                165                 170                 175     


Ala Ile Gln Glu Lys Glu Glu Gln Ser Ile Ile Ile Pro Pro Ser Xaa 
            180                 185                 190         


Ala Asn Val Asp Ile Arg Ala Phe Ile Glu Ser Cys Ser His Arg Ser 
        195                 200                 205             


Ser Ser Leu Pro Xaa Pro Val Asp Lys Gly Asn Pro Ser Ser Ile His 
    210                 215                 220                 


Pro Phe Glu Asn Leu Ile Ser Asn Met Xaa Phe Met Leu Pro Phe Gln 
225                 230                 235                 240 


Phe Phe Asn Pro Leu Pro Pro Ala Leu Ile Gly Ser Leu Pro Glu Gln 
                245                 250                 255     


Tyr Met Leu Glu Gln Gly His Asp Gln Ser Gln Asp Pro Lys Gln Glu 
            260                 265                 270         


Val His Gly Pro Phe Pro Asp Ser Ser Phe Leu Xaa Ser Ser Ser Xaa 
        275                 280                 285             


Pro Phe Gln Val Glu Lys Asp Gln Cys Leu Asn Cys Pro Asp Ala Ile 
    290                 295                 300                 


Xaa Lys Lys Glu Asp Ser Xaa His Leu Ser Asp Ser Ser Ser Tyr Asn 
305                 310                 315                 320 


Ile Val Xaa Lys Phe Glu Arg Xaa Gln Leu Ser Pro Glu Ala Lys Val 
                325                 330                 335     


Lys Pro Glu Arg Asn Ser Leu Gly Xaa Lys Lys Gly Arg Val Phe Cys 
            340                 345                 350         


Xaa Ala Cys Glu Lys Xaa Phe Tyr Asp Lys Gly Xaa Leu Lys Ile His 
        355                 360                 365             


Tyr Asn Ala Val His Leu Lys Ile Lys His Lys Cys Xaa Ile Glu Gly 
    370                 375                 380                 


Cys Asn Met Val Phe Ser Ser Leu Arg Ser Arg Asn Arg His Ser Ala 
385                 390                 395                 400 


Asn Pro Asn Pro Arg Leu His Met Pro Met Asn Arg Asn Asn Arg Asp 
                405                 410                 415     


Lys Asp Leu Arg Asn Ser Leu Asn Leu Ala Ser Ser Glu Asn Tyr Lys 
            420                 425                 430         


Cys Pro Gly Phe Xaa Val Xaa Ser Pro Asp Cys Arg Pro Pro Pro Ser 
        435                 440                 445             


Tyr Pro Gly Ser Gly Glu Asp Ser Lys Gly Gln Pro Ala Phe Pro Asn 
    450                 455                 460                 


Ile Gly Gln Asn Gly Val Leu Phe Pro Asn Leu Lys Xaa Val Gln Pro 
465                 470                 475                 480 


Val Leu Pro Phe Tyr Arg Ser Pro Ala Xaa Pro Ala Glu Val Ala Asn 
                485                 490                 495     


Xaa Pro Gly Ile Leu Pro Ser Leu Pro Leu Leu Ser Ser Ser Ile Pro 
            500                 505                 510         


Glu Gln Leu Ile Ser Asn Glu Met Pro Phe Asp Ala Leu Pro Lys Lys 
        515                 520                 525             


Lys Ser Arg Lys Ser Ser Met Pro Ile Lys Ile Glu Lys Glu Ala Val 
    530                 535                 540                 


Glu Ile Ala Asn Glu Lys Arg His Asn Leu Ser Ser Asp Glu Asp Met 
545                 550                 555                 560 


Pro Leu Gln Val Val Ser Glu Asp Glu Gln Glu Ala Cys Ser Pro Gln 
                565                 570                 575     


Ser His Arg Val Ser Glu Glu Gln His Val Gln Ser Gly Gly Leu Gly 
            580                 585                 590         


Lys Pro Phe Pro Glu Gly Glu Arg Pro Cys His Arg Glu Ser Val Ile 
        595                 600                 605             


Glu Ser Ser Gly Ala Ile Ser Gln Xaa Pro Glu Gln Ala Xaa His Asn 
    610                 615                 620                 


Ser Glu Arg Glu Xaa Glu Gln Xaa Pro Ala Leu Ile Met Val Pro Arg 
625                 630                 635                 640 


Glu Val Glu Asp Gly Gly His Glu His Tyr Phe Xaa Pro Gly Met Glu 
                645                 650                 655     


Pro Gln Val Pro Phe Ser Asp Tyr Met Glu Leu Gln Gln Arg Leu Leu 
            660                 665                 670         


Ala Gly Gly Leu Phe Ser Ala Leu Ser Asn Arg Gly Met Ala Phe Pro 
        675                 680                 685             


Cys Leu Glu Asp Ser Lys Glu Leu Glu His Val Gly Gln His Ala Leu 
    690                 695                 700                 


Ala Arg Gln Ile Glu Glu Asn Arg Phe Gln Cys Asp Ile Cys Lys Lys 
705                 710                 715                 720 


Xaa Phe Lys Asn Ala Cys Ser Val Lys Ile His His Lys Asn Met His 
                725                 730                 735     


Val Lys Glu Met His Xaa Cys Xaa Val Glu Gly Cys Asn Ala Xaa Phe 
            740                 745                 750         


Pro Ser Arg Arg Ser Arg Asp Arg His Ser Ser Asn Leu Asn Leu His 
        755                 760                 765             


Gln Lys Ala Leu Ser Gln Glu Ala Leu Glu Ser Ser Glu Asp His Phe 
    770                 775                 780                 


Arg Ala Ala Tyr Leu Leu Lys Asp Val Ala Lys Glu Ala Tyr Gln Asp 
785                 790                 795                 800 


Val Ala Phe Xaa Gln Gln Ala Ser Gln Xaa Ser Val Ile Phe Lys Gly 
                805                 810                 815     


Xaa Ser Arg Met Gly Ser Leu Val Tyr Pro Ile Xaa Gln Val His Ser 
            820                 825                 830         


Ala Ser Leu Glu Ser Tyr Asn Ser Gly Pro Leu Ser Glu Gly Xaa Ile 
        835                 840                 845             


Leu Asp Leu Ser Xaa Xaa Ser Ser Met Lys Ser Glu Ser Ser Ser His 
    850                 855                 860                 


Ser Ser Trp Asp Ser Asp Gly Val Ser Glu Glu Gly Xaa Val Leu Met 
865                 870                 875                 880 


Glu Asp Ser Asp Gly Asn Cys Glu Gly Ser Ser Leu Val Pro Gly Glu 
                885                 890                 895     


Asp Glu Tyr Pro Ile Cys Val Leu Met Glu Lys Ala Asp Gln Ser Leu 
            900                 905                 910         


Ala Ser Leu Pro Ser Gly Leu Pro Ile Xaa Cys His Leu Cys Gln Lys 
        915                 920                 925             


Xaa Tyr Ser Asn Lys Gly Xaa Phe Arg Ala His Tyr Lys Xaa Val His 
    930                 935                 940                 


Leu Arg Gln Leu His Lys Cys Lys Val Pro Gly Cys Asn Xaa Met Phe 
945                 950                 955                 960 


Ser Ser Val Arg Ser Arg Asn Arg His Ser Gln Asn Pro Asn Leu His 
                965                 970                 975     


Lys Ser Leu Ala Ser Ser Pro Ser His Leu Gln 
            980                 985         


<210> 4293
<211> 994
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<400> 4293
Met Arg Arg Arg Pro Pro Ser Arg Gly Gly Arg Gly Ala Ala Arg Ala 
1               5                   10                  15      


Arg Glu Xaa Arg Arg Gln Pro Arg His Arg Ser Gly Arg Arg Met Ala 
            20                  25                  30          


Glu Ala Ile Ser Cys Xaa Leu Asn Cys Ser Cys Gln Ser Phe Lys Pro 
        35                  40                  45              


Gly Lys Ile Asn His Arg Gln Cys Asp Gln Cys Lys His Gly Trp Val 
    50                  55                  60                  


Ala His Ala Leu Ser Lys Leu Arg Ile Pro Pro Met Tyr Pro Xaa Ser 
65                  70                  75                  80  


Gln Val Glu Ile Val Gln Ser Asn Val Val Phe Asp Ile Ser Ser Leu 
                85                  90                  95      


Met Leu Tyr Gly Xaa Gln Ala Ile Pro Val Arg Leu Lys Ile Leu Leu 
            100                 105                 110         


Asp Arg Leu Phe Ser Val Leu Lys Gln Asp Glu Val Leu Gln Ile Leu 
        115                 120                 125             


His Ala Leu Asp Trp Xaa Leu Gln Asp Tyr Ile Arg Gly Tyr Val Leu 
    130                 135                 140                 


Gln Asp Ala Ser Gly Lys Val Leu Asp His Trp Ser Ile Met Xaa Ser 
145                 150                 155                 160 


Glu Glu Glu Val Ala Xaa Leu Gln Gln Phe Leu Arg Phe Gly Glu Xaa 
                165                 170                 175     


Lys Ser Ile Val Glu Leu Met Ala Ile Gln Glu Lys Glu Glu Gln Ser 
            180                 185                 190         


Ile Ile Ile Pro Pro Ser Xaa Ala Asn Val Asp Ile Arg Ala Phe Ile 
        195                 200                 205             


Glu Ser Cys Ser His Arg Ser Ser Ser Leu Pro Xaa Pro Val Asp Lys 
    210                 215                 220                 


Gly Asn Pro Ser Ser Ile His Pro Phe Glu Asn Leu Ile Ser Asn Met 
225                 230                 235                 240 


Xaa Phe Met Leu Pro Phe Gln Phe Phe Asn Pro Leu Pro Pro Ala Leu 
                245                 250                 255     


Ile Gly Ser Leu Pro Glu Gln Tyr Met Leu Glu Gln Gly His Asp Gln 
            260                 265                 270         


Ser Gln Asp Pro Lys Gln Glu Val His Gly Pro Phe Pro Asp Ser Ser 
        275                 280                 285             


Phe Leu Xaa Ser Ser Ser Xaa Pro Phe Gln Val Glu Lys Asp Gln Cys 
    290                 295                 300                 


Leu Asn Cys Pro Asp Ala Ile Xaa Lys Lys Glu Asp Ser Xaa His Leu 
305                 310                 315                 320 


Ser Asp Ser Ser Ser Tyr Asn Ile Val Xaa Lys Phe Glu Arg Xaa Gln 
                325                 330                 335     


Leu Ser Pro Glu Ala Lys Val Lys Pro Glu Arg Asn Ser Leu Gly Xaa 
            340                 345                 350         


Lys Lys Gly Arg Val Phe Cys Xaa Ala Cys Glu Lys Xaa Phe Tyr Asp 
        355                 360                 365             


Lys Gly Xaa Leu Lys Ile His Tyr Asn Ala Val His Leu Lys Ile Lys 
    370                 375                 380                 


His Lys Cys Xaa Ile Glu Gly Cys Asn Met Val Phe Ser Ser Leu Arg 
385                 390                 395                 400 


Ser Arg Asn Arg His Ser Ala Asn Pro Asn Pro Arg Leu His Met Pro 
                405                 410                 415     


Met Asn Arg Asn Asn Arg Asp Lys Asp Leu Arg Asn Ser Leu Asn Leu 
            420                 425                 430         


Ala Ser Ser Glu Asn Tyr Lys Cys Pro Gly Phe Xaa Val Xaa Ser Pro 
        435                 440                 445             


Asp Cys Arg Pro Pro Pro Ser Tyr Pro Gly Ser Gly Glu Asp Ser Lys 
    450                 455                 460                 


Gly Gln Pro Ala Phe Pro Asn Ile Gly Gln Asn Gly Val Leu Phe Pro 
465                 470                 475                 480 


Asn Leu Lys Xaa Val Gln Pro Val Leu Pro Phe Tyr Arg Ser Pro Ala 
                485                 490                 495     


Xaa Pro Ala Glu Val Ala Asn Xaa Pro Gly Ile Leu Pro Ser Leu Pro 
            500                 505                 510         


Leu Leu Ser Ser Ser Ile Pro Glu Gln Leu Ile Ser Asn Glu Met Pro 
        515                 520                 525             


Phe Asp Ala Leu Pro Lys Lys Lys Ser Arg Lys Ser Ser Met Pro Ile 
    530                 535                 540                 


Lys Ile Glu Lys Glu Ala Val Glu Ile Ala Asn Glu Lys Arg His Asn 
545                 550                 555                 560 


Leu Ser Ser Asp Glu Asp Met Pro Leu Gln Val Val Ser Glu Asp Glu 
                565                 570                 575     


Gln Glu Ala Cys Ser Pro Gln Ser His Arg Val Ser Glu Glu Gln His 
            580                 585                 590         


Val Gln Ser Gly Gly Leu Gly Lys Pro Phe Pro Glu Gly Glu Arg Pro 
        595                 600                 605             


Cys His Arg Glu Ser Val Ile Glu Ser Ser Gly Ala Ile Ser Gln Xaa 
    610                 615                 620                 


Pro Glu Gln Ala Xaa His Asn Ser Glu Arg Glu Xaa Glu Gln Xaa Pro 
625                 630                 635                 640 


Ala Leu Ile Met Val Pro Arg Glu Val Glu Asp Gly Gly His Glu His 
                645                 650                 655     


Tyr Phe Xaa Pro Gly Met Glu Pro Gln Val Pro Phe Ser Asp Tyr Met 
            660                 665                 670         


Glu Leu Gln Gln Arg Leu Leu Ala Gly Gly Leu Phe Ser Ala Leu Ser 
        675                 680                 685             


Asn Arg Gly Met Ala Phe Pro Cys Leu Glu Asp Ser Lys Glu Leu Glu 
    690                 695                 700                 


His Val Gly Gln His Ala Leu Ala Arg Gln Ile Glu Glu Asn Arg Phe 
705                 710                 715                 720 


Gln Cys Asp Ile Cys Lys Lys Xaa Phe Lys Asn Ala Cys Ser Val Lys 
                725                 730                 735     


Ile His His Lys Asn Met His Val Lys Glu Met His Xaa Cys Xaa Val 
            740                 745                 750         


Glu Gly Cys Asn Ala Xaa Phe Pro Ser Arg Arg Ser Arg Asp Arg His 
        755                 760                 765             


Ser Ser Asn Leu Asn Leu His Gln Lys Ala Leu Ser Gln Glu Ala Leu 
    770                 775                 780                 


Glu Ser Ser Glu Asp His Phe Arg Ala Ala Tyr Leu Leu Lys Asp Val 
785                 790                 795                 800 


Ala Lys Glu Ala Tyr Gln Asp Val Ala Phe Xaa Gln Gln Ala Ser Gln 
                805                 810                 815     


Xaa Ser Val Ile Phe Lys Gly Xaa Ser Arg Met Gly Ser Leu Val Tyr 
            820                 825                 830         


Pro Ile Xaa Gln Val His Ser Ala Ser Leu Glu Ser Tyr Asn Ser Gly 
        835                 840                 845             


Pro Leu Ser Glu Gly Xaa Ile Leu Asp Leu Ser Xaa Xaa Ser Ser Met 
    850                 855                 860                 


Lys Ser Glu Ser Ser Ser His Ser Ser Trp Asp Ser Asp Gly Val Ser 
865                 870                 875                 880 


Glu Glu Gly Xaa Val Leu Met Glu Asp Ser Asp Gly Asn Cys Glu Gly 
                885                 890                 895     


Ser Ser Leu Val Pro Gly Glu Asp Glu Tyr Pro Ile Cys Val Leu Met 
            900                 905                 910         


Glu Lys Ala Asp Gln Ser Leu Ala Ser Leu Pro Ser Gly Leu Pro Ile 
        915                 920                 925             


Xaa Cys His Leu Cys Gln Lys Xaa Tyr Ser Asn Lys Gly Xaa Phe Arg 
    930                 935                 940                 


Ala His Tyr Lys Xaa Val His Leu Arg Gln Leu His Lys Cys Lys Val 
945                 950                 955                 960 


Pro Gly Cys Asn Xaa Met Phe Ser Ser Val Arg Ser Arg Asn Arg His 
                965                 970                 975     


Ser Gln Asn Pro Asn Leu His Lys Ser Leu Ala Ser Ser Pro Ser His 
            980                 985                 990         


Leu Gln 
        


<210> 4294
<211> 1032
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<400> 4294
Met Ala His Leu Gly Pro Xaa Pro Pro Pro His Ser Leu Asn Tyr Lys 
1               5                   10                  15      


Ser Glu Asp Arg Leu Ser Glu Gln Asp Trp Pro Ala Tyr Phe Lys Val 
            20                  25                  30          


Pro Cys Cys Gly Val Asp Xaa Ser Gln Ile Glu Ala Ile Arg Cys Xaa 
        35                  40                  45              


Leu Val Asn Cys Xaa Cys Glu Cys Phe Gln Pro Gly Lys Ile Asn Leu 
    50                  55                  60                  


Arg Xaa Cys Asp Gln Cys Lys His Gly Trp Val Ala His Ala Leu Asp 
65                  70                  75                  80  


Lys Leu Ser Xaa Gln His Leu Tyr His Pro Xaa Gln Val Glu Ile Val 
                85                  90                  95      


Gln Ser Asn Val Val Phe Asp Ile Ser Ser Leu Met Leu Tyr Gly Xaa 
            100                 105                 110         


Gln Ala Val Pro Val Arg Leu Lys Ile Leu Leu Asp Arg Leu Phe Ser 
        115                 120                 125             


Val Leu Lys Gln Glu Glu Val Leu His Ile Leu His Gly Leu Gly Trp 
    130                 135                 140                 


Xaa Leu Arg Asp Tyr Val Arg Gly Tyr Ile Leu Gln Asp Ala Ala Gly 
145                 150                 155                 160 


Lys Val Leu Asp Arg Trp Ala Ile Met Ser Arg Glu Glu Glu Ile Ile 
                165                 170                 175     


Xaa Leu Gln Gln Phe Leu Arg Phe Gly Glu Xaa Lys Ser Ile Val Glu 
            180                 185                 190         


Leu Met Ala Ile Gln Glu Lys Glu Gly Gln Ala Val Ala Val Pro Ser 
        195                 200                 205             


Ser Lys Xaa Asp Ser Asp Ile Arg Xaa Phe Ile Glu Ser Asn Asn Arg 
    210                 215                 220                 


Xaa Arg Ser Pro Ser Leu Leu Ala His Leu Glu Asn Ser Asn Pro Ser 
225                 230                 235                 240 


Ser Ile His His Phe Glu Asn Ile Pro Asn Ser Leu Ala Phe Leu Leu 
                245                 250                 255     


Pro Phe Gln Tyr Ile Asn Pro Val Ser Ala Pro Leu Leu Gly Leu Pro 
            260                 265                 270         


Pro Asn Gly Leu Leu Leu Glu Gln Pro Gly Leu Arg Leu Arg Glu Pro 
        275                 280                 285             


Ser Leu Ser Xaa Gln Asn Glu Tyr Asn Glu Ser Ser Glu Ser Glu Val 
    290                 295                 300                 


Ser Pro Xaa Pro Tyr Lys Asn Asp Gln Xaa Pro Asn Arg Asn Ala Leu 
305                 310                 315                 320 


Xaa Ser Ile Xaa Asn Val Glu Pro Lys Xaa Glu Pro Ala Cys Val Ser 
                325                 330                 335     


Pro Ile Gln Asn Ser Ala Pro Val Ser Asp Leu Xaa Lys Xaa Glu His 
            340                 345                 350         


Pro Lys Ser Ser Phe Arg Ile His Arg Met Arg Arg Met Gly Ser Ala 
        355                 360                 365             


Ser Arg Lys Gly Arg Val Phe Cys Asn Ala Cys Gly Lys Xaa Phe Tyr 
    370                 375                 380                 


Asp Lys Gly Xaa Leu Lys Ile His Tyr Asn Ala Val His Leu Lys Ile 
385                 390                 395                 400 


Lys His Arg Cys Xaa Ile Glu Gly Cys Asn Met Val Phe Ser Ser Leu 
                405                 410                 415     


Arg Ser Arg Asn Arg His Ser Ala Asn Pro Asn Pro Arg Leu His Met 
            420                 425                 430         


Pro Met Leu Arg Asn Asn Arg Asp Lys Asp Leu Ile Arg Ala Xaa Ser 
        435                 440                 445             


Gly Ala Ala Xaa Pro Val Ile Ala Ser Xaa Lys Ser Asn Leu Ala Leu 
    450                 455                 460                 


Xaa Ser Pro Gly Arg Pro Pro Met Gly Phe Xaa Xaa Pro Pro Leu Asp 
465                 470                 475                 480 


Pro Val Leu Gln Asn Pro Leu Pro Ser Gln Leu Val Phe Ser Gly Leu 
                485                 490                 495     


Lys Xaa Val Gln Pro Val Pro Pro Phe Tyr Arg Ser Leu Leu Xaa Pro 
            500                 505                 510         


Gly Glu Met Val Ser Pro Pro Xaa Ser Leu Pro Xaa Ser Pro Ile Ile 
        515                 520                 525             


Pro Xaa Ser Gly Xaa Ile Glu Gln His Pro Pro Pro Pro Ser Glu Pro 
    530                 535                 540                 


Val Val Pro Ala Val Met Met Ala Xaa His Glu Pro Ser Ala Asp Leu 
545                 550                 555                 560 


Ala Pro Lys Lys Lys Pro Arg Lys Ser Ser Met Pro Val Lys Ile Glu 
                565                 570                 575     


Lys Glu Ile Ile Asp Xaa Ala Asp Glu Phe Asp Asp Glu Asp Asp Asp 
            580                 585                 590         


Pro Asn Asp Gly Gly Ala Val Val Asn Asp Met Ser His Asp Asn His 
        595                 600                 605             


Cys His Ser Gln Glu Glu Met Ser Pro Gly Met Ser Val Lys Asp Phe 
    610                 615                 620                 


Ser Lys His Asn Arg Xaa Arg Cys Ile Ser Arg Xaa Glu Ile Arg Arg 
625                 630                 635                 640 


Ala Asp Ser Met Xaa Ser Glu Asp Gln Glu Pro Glu Arg Asp Tyr Glu 
                645                 650                 655     


Asn Glu Ser Glu Ser Ser Glu Pro Lys Leu Gly Glu Glu Ser Met Glu 
            660                 665                 670         


Gly Asp Glu His Ile His Ser Glu Val Ser Glu Lys Val Leu Met Asn 
        675                 680                 685             


Ser Glu Arg Pro Asp Glu Asn His Ser Glu Pro Ser His Gln Asp Val 
    690                 695                 700                 


Ile Lys Val Lys Glu Glu Phe Xaa Asp Pro Xaa Tyr Asp Met Phe Tyr 
705                 710                 715                 720 


Met Ser Gln Tyr Gly Leu Tyr Asn Gly Gly Gly Ala Ser Met Ala Ala 
                725                 730                 735     


Leu His Glu Ser Phe Xaa Ser Ser Leu Asn Tyr Gly Ser Pro Gln Lys 
            740                 745                 750         


Phe Ser Pro Glu Gly Asp Leu Cys Ser Ser Pro Asp Pro Lys Ile Cys 
        755                 760                 765             


Tyr Val Cys Lys Lys Ser Phe Lys Ser Ser Tyr Ser Val Lys Leu His 
    770                 775                 780                 


Tyr Arg Asn Val His Leu Lys Glu Met His Val Cys Xaa Val Ala Gly 
785                 790                 795                 800 


Cys Asn Ala Ala Phe Pro Ser Arg Arg Ser Arg Asp Arg His Ser Ala 
                805                 810                 815     


Asn Ile Asn Leu His Arg Lys Leu Leu Xaa Lys Glu Leu Asp Asp Met 
            820                 825                 830         


Gly Leu Asp Ser Ser Gln Pro Ser Leu Ser Lys Asp Leu Arg Asp Glu 
        835                 840                 845             


Phe Leu Val Lys Ile Tyr Gly Ala Gln His Pro Met Gly Leu Asp Val 
    850                 855                 860                 


Arg Glu Asp Ala Ser Ser Pro Ala Gly Xaa Glu Asp Ser His Leu Asn 
865                 870                 875                 880 


Gly Tyr Gly Arg Gly Met Ala Glu Asp Tyr Met Val Leu Asp Leu Ser 
                885                 890                 895     


Xaa Xaa Ser Ser Leu Gln Ser Ser Ser Ser Ile His Ser Ser Arg Glu 
            900                 905                 910         


Ser Asp Ala Gly Ser Asp Glu Gly Ile Leu Leu Asp Asp Ile Asp Gly 
        915                 920                 925             


Ala Ser Asp Ser Gly Glu Ser Ala His Lys Ala Glu Ala Pro Ala Leu 
    930                 935                 940                 


Pro Gly Ser Leu Gly Ala Glu Val Ser Gly Ser Leu Met Phe Ser Ser 
945                 950                 955                 960 


Leu Ser Gly Ser Asn Gly Gly Ile Met Cys Asn Ile Cys His Lys Met 
                965                 970                 975     


Tyr Ser Asn Lys Gly Xaa Leu Arg Val His Tyr Lys Xaa Val His Leu 
            980                 985                 990         


Arg Glu Met His Lys Cys Lys Val  Pro Gly Cys Asn Met  Met Phe Ser 
        995                 1000                 1005             


Ser Val  Arg Ser Arg Asn Arg  His Ser Gln Asn Pro  Asn Leu His 
    1010                 1015                 1020             


Lys Asn  Ile Pro Phe Xaa Ser  Val Asp 
    1025                 1030         


<210> 4295
<211> 903
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<400> 4295
Met Ala His Leu Gly Pro Xaa Pro Pro Pro His Ser Leu Asn Tyr Lys 
1               5                   10                  15      


Ser Glu Asp Arg Leu Ser Glu Gln Asp Trp Pro Ala Tyr Phe Lys Val 
            20                  25                  30          


Pro Cys Cys Gly Val Asp Xaa Ser Gln Ile Glu Ser Glu Glu Ala Glu 
        35                  40                  45              


Val Asp Val Arg Glu Arg Glu Xaa Gln Arg Asp Arg Glu Pro Lys Arg 
    50                  55                  60                  


Ala Arg Asp Leu Xaa Leu Arg Asp Ser Cys Xaa Asp Asn Ser Met Gln 
65                  70                  75                  80  


Phe Gly Xaa Arg Xaa Xaa Xaa Ala Glu Pro Gly Phe Met Gly Xaa Trp 
                85                  90                  95      


Gln Asn Ala Asp Xaa Asn Leu Leu Phe Arg Met Ser Gln Gln Ala Ile 
            100                 105                 110         


Arg Cys Xaa Leu Val Asn Cys Xaa Cys Glu Cys Phe Gln Pro Gly Lys 
        115                 120                 125             


Ile Asn Leu Arg Xaa Cys Asp Gln Cys Lys His Gly Trp Val Ala His 
    130                 135                 140                 


Ala Leu Asp Lys Leu Ser Xaa Gln His Leu Tyr His Pro Xaa Gln Val 
145                 150                 155                 160 


Glu Ile Val Gln Ser Asn Val Val Phe Asp Ile Ser Ser Leu Met Leu 
                165                 170                 175     


Tyr Gly Xaa Gln Ala Val Pro Val Arg Leu Lys Ile Leu Leu Asp Arg 
            180                 185                 190         


Leu Phe Ser Val Leu Lys Gln Glu Glu Val Leu His Ile Leu His Gly 
        195                 200                 205             


Leu Gly Trp Xaa Leu Arg Asp Tyr Val Arg Gly Tyr Ile Leu Gln Asp 
    210                 215                 220                 


Ala Ala Gly Lys Val Leu Asp Arg Trp Ala Ile Met Ser Arg Glu Glu 
225                 230                 235                 240 


Glu Ile Ile Xaa Leu Gln Gln Phe Leu Arg Phe Gly Glu Xaa Lys Ser 
                245                 250                 255     


Ile Val Glu Leu Met Ala Ile Gln Glu Lys Glu Gly Gln Ala Val Ala 
            260                 265                 270         


Val Pro Ser Ser Lys Xaa Asp Ser Asp Ile Arg Xaa Phe Ile Glu Ser 
        275                 280                 285             


Asn Asn Arg Xaa Arg Ser Pro Ser Leu Leu Ala His Leu Glu Asn Ser 
    290                 295                 300                 


Asn Pro Ser Ser Ile His His Phe Glu Asn Ile Pro Asn Ser Leu Ala 
305                 310                 315                 320 


Phe Leu Leu Pro Phe Gln Tyr Ile Asn Pro Val Ser Ala Pro Leu Leu 
                325                 330                 335     


Gly Leu Pro Pro Asn Gly Leu Leu Leu Glu Gln Pro Gly Leu Arg Leu 
            340                 345                 350         


Arg Glu Pro Ser Leu Ser Xaa Gln Asn Glu Tyr Asn Glu Ser Ser Glu 
        355                 360                 365             


Ser Glu Val Ser Pro Xaa Pro Tyr Lys Asn Asp Gln Xaa Pro Asn Arg 
    370                 375                 380                 


Asn Ala Leu Xaa Ser Ile Xaa Asn Val Glu Pro Lys Xaa Glu Pro Ala 
385                 390                 395                 400 


Cys Val Ser Pro Ile Gln Asn Ser Ala Pro Val Ser Asp Leu Xaa Lys 
                405                 410                 415     


Xaa Glu His Pro Lys Ser Ser Phe Arg Ile His Arg Met Arg Arg Met 
            420                 425                 430         


Gly Ser Ala Ser Arg Lys Gly Arg Val Phe Cys Asn Ala Cys Gly Lys 
        435                 440                 445             


Xaa Phe Tyr Asp Lys Gly Xaa Leu Lys Ile His Tyr Asn Ala Val His 
    450                 455                 460                 


Leu Lys Ile Lys His Arg Cys Xaa Ile Glu Gly Cys Asn Met Val Phe 
465                 470                 475                 480 


Ser Ser Leu Arg Ser Arg Asn Arg His Ser Ala Asn Pro Asn Pro Arg 
                485                 490                 495     


Leu His Met Pro Met Leu Arg Asn Asn Arg Asp Lys Asp Leu Ile Arg 
            500                 505                 510         


Ala Xaa Ser Gly Ala Ala Xaa Pro Val Ile Ala Ser Xaa Lys Ser Asn 
        515                 520                 525             


Leu Ala Leu Xaa Ser Pro Gly Arg Pro Pro Met Gly Phe Xaa Xaa Pro 
    530                 535                 540                 


Pro Leu Asp Pro Val Leu Gln Asn Pro Leu Pro Ser Gln Leu Val Phe 
545                 550                 555                 560 


Ser Gly Leu Lys Xaa Val Gln Pro Val Pro Pro Phe Tyr Arg Ser Leu 
                565                 570                 575     


Leu Xaa Pro Gly Glu Met Val Ser Pro Pro Xaa Ser Leu Pro Xaa Ser 
            580                 585                 590         


Pro Ile Ile Pro Xaa Ser Gly Xaa Ile Glu Gln His Pro Pro Pro Pro 
        595                 600                 605             


Ser Glu Pro Val Val Pro Ala Val Met Met Ala Xaa His Glu Pro Ser 
    610                 615                 620                 


Ala Asp Leu Ala Pro Lys Lys Lys Pro Arg Lys Ser Ser Met Pro Val 
625                 630                 635                 640 


Lys Ile Glu Lys Glu Ile Ile Asp Xaa Ala Asp Glu Phe Asp Asp Glu 
                645                 650                 655     


Asp Asp Asp Pro Asn Asp Gly Gly Ala Val Val Asn Asp Met Ser His 
            660                 665                 670         


Asp Asn His Cys His Ser Gln Glu Glu Met Ser Pro Gly Met Ser Val 
        675                 680                 685             


Lys Asp Phe Ser Lys His Asn Arg Xaa Arg Cys Ile Ser Arg Xaa Glu 
    690                 695                 700                 


Ile Arg Arg Ala Asp Ser Met Xaa Ser Glu Asp Gln Glu Pro Glu Arg 
705                 710                 715                 720 


Asp Tyr Glu Asn Glu Ser Glu Ser Ser Glu Pro Lys Leu Gly Glu Glu 
                725                 730                 735     


Ser Met Glu Gly Asp Glu His Ile His Ser Glu Val Ser Glu Lys Val 
            740                 745                 750         


Leu Met Asn Ser Glu Arg Pro Asp Glu Asn His Ser Glu Pro Ser His 
        755                 760                 765             


Gln Asp Val Ile Lys Val Lys Glu Glu Phe Xaa Asp Pro Xaa Tyr Asp 
    770                 775                 780                 


Met Phe Tyr Met Ser Gln Tyr Gly Leu Tyr Asn Gly Gly Gly Ala Ser 
785                 790                 795                 800 


Met Ala Ala Leu His Glu Ser Phe Xaa Ser Ser Leu Asn Tyr Gly Ser 
                805                 810                 815     


Pro Gln Lys Phe Ser Pro Glu Gly Asp Leu Cys Ser Ser Pro Asp Pro 
            820                 825                 830         


Lys Ile Cys Tyr Val Cys Lys Lys Ser Phe Lys Ser Ser Tyr Ser Val 
        835                 840                 845             


Lys Leu His Tyr Arg Asn Val His Leu Lys Glu Met His Val Cys Xaa 
    850                 855                 860                 


Val Ala Gly Cys Asn Ala Ala Phe Pro Ser Arg Arg Ser Arg Asp Arg 
865                 870                 875                 880 


Tyr Trp Glu Lys Ser Asn Glu Gln Asn Gly Leu Leu Val Ser Trp Gly 
                885                 890                 895     


Glu Xaa Leu Ser Ser Leu Lys 
            900             


<210> 4296
<211> 1099
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<400> 4296
Met Ala His Leu Gly Pro Xaa Pro Pro Pro His Ser Leu Asn Tyr Lys 
1               5                   10                  15      


Ser Glu Asp Arg Leu Ser Glu Gln Asp Trp Pro Ala Tyr Phe Lys Val 
            20                  25                  30          


Pro Cys Cys Gly Val Asp Xaa Ser Gln Ile Glu Ser Glu Glu Ala Glu 
        35                  40                  45              


Val Asp Val Arg Glu Arg Glu Xaa Gln Arg Asp Arg Glu Pro Lys Arg 
    50                  55                  60                  


Ala Arg Asp Leu Xaa Leu Arg Asp Ser Cys Xaa Asp Asn Ser Met Gln 
65                  70                  75                  80  


Phe Gly Xaa Arg Xaa Xaa Xaa Ala Glu Pro Gly Phe Met Gly Xaa Trp 
                85                  90                  95      


Gln Asn Ala Asp Xaa Asn Leu Leu Phe Arg Met Ser Gln Gln Ala Ile 
            100                 105                 110         


Arg Cys Xaa Leu Val Asn Cys Xaa Cys Glu Cys Phe Gln Pro Gly Lys 
        115                 120                 125             


Ile Asn Leu Arg Xaa Cys Asp Gln Cys Lys His Gly Trp Val Ala His 
    130                 135                 140                 


Ala Leu Asp Lys Leu Ser Xaa Gln His Leu Tyr His Pro Xaa Gln Val 
145                 150                 155                 160 


Glu Ile Val Gln Ser Asn Val Val Phe Asp Ile Ser Ser Leu Met Leu 
                165                 170                 175     


Tyr Gly Xaa Gln Ala Val Pro Val Arg Leu Lys Ile Leu Leu Asp Arg 
            180                 185                 190         


Leu Phe Ser Val Leu Lys Gln Glu Glu Val Leu His Ile Leu His Gly 
        195                 200                 205             


Leu Gly Trp Xaa Leu Arg Asp Tyr Val Arg Gly Tyr Ile Leu Gln Asp 
    210                 215                 220                 


Ala Ala Gly Lys Val Leu Asp Arg Trp Ala Ile Met Ser Arg Glu Glu 
225                 230                 235                 240 


Glu Ile Ile Xaa Leu Gln Gln Phe Leu Arg Phe Gly Glu Xaa Lys Ser 
                245                 250                 255     


Ile Val Glu Leu Met Ala Ile Gln Glu Lys Glu Gly Gln Ala Val Ala 
            260                 265                 270         


Val Pro Ser Ser Lys Xaa Asp Ser Asp Ile Arg Xaa Phe Ile Glu Ser 
        275                 280                 285             


Asn Asn Arg Xaa Arg Ser Pro Ser Leu Leu Ala His Leu Glu Asn Ser 
    290                 295                 300                 


Asn Pro Ser Ser Ile His His Phe Glu Asn Ile Pro Asn Ser Leu Ala 
305                 310                 315                 320 


Phe Leu Leu Pro Phe Gln Tyr Ile Asn Pro Val Ser Ala Pro Leu Leu 
                325                 330                 335     


Gly Leu Pro Pro Asn Gly Leu Leu Leu Glu Gln Pro Gly Leu Arg Leu 
            340                 345                 350         


Arg Glu Pro Ser Leu Ser Xaa Gln Asn Glu Tyr Asn Glu Ser Ser Glu 
        355                 360                 365             


Ser Glu Val Ser Pro Xaa Pro Tyr Lys Asn Asp Gln Xaa Pro Asn Arg 
    370                 375                 380                 


Asn Ala Leu Xaa Ser Ile Xaa Asn Val Glu Pro Lys Xaa Glu Pro Ala 
385                 390                 395                 400 


Cys Val Ser Pro Ile Gln Asn Ser Ala Pro Val Ser Asp Leu Xaa Lys 
                405                 410                 415     


Xaa Glu His Pro Lys Ser Ser Phe Arg Ile His Arg Met Arg Arg Met 
            420                 425                 430         


Gly Ser Ala Ser Arg Lys Gly Arg Val Phe Cys Asn Ala Cys Gly Lys 
        435                 440                 445             


Xaa Phe Tyr Asp Lys Gly Xaa Leu Lys Ile His Tyr Asn Ala Val His 
    450                 455                 460                 


Leu Lys Ile Lys His Arg Cys Xaa Ile Glu Gly Cys Asn Met Val Phe 
465                 470                 475                 480 


Ser Ser Leu Arg Ser Arg Asn Arg His Ser Ala Asn Pro Asn Pro Arg 
                485                 490                 495     


Leu His Met Pro Met Leu Arg Asn Asn Arg Asp Lys Asp Leu Ile Arg 
            500                 505                 510         


Ala Xaa Ser Gly Ala Ala Xaa Pro Val Ile Ala Ser Xaa Lys Ser Asn 
        515                 520                 525             


Leu Ala Leu Xaa Ser Pro Gly Arg Pro Pro Met Gly Phe Xaa Xaa Pro 
    530                 535                 540                 


Pro Leu Asp Pro Val Leu Gln Asn Pro Leu Pro Ser Gln Leu Val Phe 
545                 550                 555                 560 


Ser Gly Leu Lys Xaa Val Gln Pro Val Pro Pro Phe Tyr Arg Ser Leu 
                565                 570                 575     


Leu Xaa Pro Gly Glu Met Val Ser Pro Pro Xaa Ser Leu Pro Xaa Ser 
            580                 585                 590         


Pro Ile Ile Pro Xaa Ser Gly Xaa Ile Glu Gln His Pro Pro Pro Pro 
        595                 600                 605             


Ser Glu Pro Val Val Pro Ala Val Met Met Ala Xaa His Glu Pro Ser 
    610                 615                 620                 


Ala Asp Leu Ala Pro Lys Lys Lys Pro Arg Lys Ser Ser Met Pro Val 
625                 630                 635                 640 


Lys Ile Glu Lys Glu Ile Ile Asp Xaa Ala Asp Glu Phe Asp Asp Glu 
                645                 650                 655     


Asp Asp Asp Pro Asn Asp Gly Gly Ala Val Val Asn Asp Met Ser His 
            660                 665                 670         


Asp Asn His Cys His Ser Gln Glu Glu Met Ser Pro Gly Met Ser Val 
        675                 680                 685             


Lys Asp Phe Ser Lys His Asn Arg Xaa Arg Cys Ile Ser Arg Xaa Glu 
    690                 695                 700                 


Ile Arg Arg Ala Asp Ser Met Xaa Ser Glu Asp Gln Glu Pro Glu Arg 
705                 710                 715                 720 


Asp Tyr Glu Asn Glu Ser Glu Ser Ser Glu Pro Lys Leu Gly Glu Glu 
                725                 730                 735     


Ser Met Glu Gly Asp Glu His Ile His Ser Glu Val Ser Glu Lys Val 
            740                 745                 750         


Leu Met Asn Ser Glu Arg Pro Asp Glu Asn His Ser Glu Pro Ser His 
        755                 760                 765             


Gln Asp Val Ile Lys Val Lys Glu Glu Phe Xaa Asp Pro Xaa Tyr Asp 
    770                 775                 780                 


Met Phe Tyr Met Ser Gln Tyr Gly Leu Tyr Asn Gly Gly Gly Ala Ser 
785                 790                 795                 800 


Met Ala Ala Leu His Glu Ser Phe Xaa Ser Ser Leu Asn Tyr Gly Ser 
                805                 810                 815     


Pro Gln Lys Phe Ser Pro Glu Gly Asp Leu Cys Ser Ser Pro Asp Pro 
            820                 825                 830         


Lys Ile Cys Tyr Val Cys Lys Lys Ser Phe Lys Ser Ser Tyr Ser Val 
        835                 840                 845             


Lys Leu His Tyr Arg Asn Val His Leu Lys Glu Met His Val Cys Xaa 
    850                 855                 860                 


Val Ala Gly Cys Asn Ala Ala Phe Pro Ser Arg Arg Ser Arg Asp Arg 
865                 870                 875                 880 


His Ser Ala Asn Ile Asn Leu His Arg Lys Leu Leu Xaa Lys Glu Leu 
                885                 890                 895     


Asp Asp Met Gly Leu Asp Ser Ser Gln Pro Ser Leu Ser Lys Asp Leu 
            900                 905                 910         


Arg Asp Glu Phe Leu Val Lys Ile Tyr Gly Ala Gln His Pro Met Gly 
        915                 920                 925             


Leu Asp Val Arg Glu Asp Ala Ser Ser Pro Ala Gly Xaa Glu Asp Ser 
    930                 935                 940                 


His Leu Asn Gly Tyr Gly Arg Gly Met Ala Glu Asp Tyr Met Val Leu 
945                 950                 955                 960 


Asp Leu Ser Xaa Xaa Ser Ser Leu Gln Ser Ser Ser Ser Ile His Ser 
                965                 970                 975     


Ser Arg Glu Ser Asp Ala Gly Ser Asp Glu Gly Ile Leu Leu Asp Asp 
            980                 985                 990         


Ile Asp Gly Ala Ser Asp Ser Gly  Glu Ser Ala His Lys  Ala Glu Ala 
        995                 1000                 1005             


Pro Ala  Leu Pro Gly Ser Leu  Gly Ala Glu Val Ser  Gly Ser Leu 
    1010                 1015                 1020             


Met Phe  Ser Ser Leu Ser Gly  Ser Asn Gly Gly Ile  Met Cys Asn 
    1025                 1030                 1035             


Ile Cys  His Lys Met Tyr Ser  Asn Lys Gly Xaa Leu  Arg Val His 
    1040                 1045                 1050             


Tyr Lys  Xaa Val His Leu Arg  Glu Met His Lys Cys  Lys Val Pro 
    1055                 1060                 1065             


Gly Cys  Asn Met Met Phe Ser  Ser Val Arg Ser Arg  Asn Arg His 
    1070                 1075                 1080             


Ser Gln  Asn Pro Asn Leu His  Lys Asn Ile Pro Phe  Xaa Ser Val 
    1085                 1090                 1095             


Asp 
    


<210> 4297
<211> 43
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<400> 4297
Met Ala Ile Arg Cys Xaa Leu Val Asn Cys Xaa Cys Glu Cys Phe Gln 
1               5                   10                  15      


Pro Gly Lys Ile Asn Leu Arg Xaa Cys Asp Gln Cys Lys His Gly Trp 
            20                  25                  30          


Val Ala His Glu Xaa Leu Lys Ser Cys Leu Gln 
        35                  40              


<210> 4298
<211> 729
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<400> 4298
Met Leu Tyr Gly Xaa Gln Ala Val Pro Val Arg Leu Lys Ile Leu Leu 
1               5                   10                  15      


Asp Arg Leu Phe Ser Val Leu Lys Gln Glu Glu Val Leu His Ile Leu 
            20                  25                  30          


His Gly Leu Gly Trp Xaa Leu Arg Asp Tyr Val Arg Gly Tyr Ile Leu 
        35                  40                  45              


Gln Asp Ala Ala Gly Lys Val Leu Asp Arg Trp Ala Ile Met Ser Arg 
    50                  55                  60                  


Glu Glu Glu Ile Ile Xaa Leu Gln Gln Phe Leu Arg Phe Gly Glu Xaa 
65                  70                  75                  80  


Lys Ser Ile Val Glu Leu Met Ala Ile Gln Glu Lys Glu Gly Gln Ala 
                85                  90                  95      


Val Ala Val Pro Ser Ser Lys Xaa Asp Ser Asp Ile Arg Xaa Phe Ile 
            100                 105                 110         


Glu Ser Asn Asn Arg Xaa Arg Ser Pro Ser Leu Leu Ala His Leu Glu 
        115                 120                 125             


Asn Ser Asn Pro Ser Ser Ile His His Phe Glu Asn Ile Pro Asn Ser 
    130                 135                 140                 


Leu Ala Phe Leu Leu Pro Phe Gln Tyr Ile Asn Pro Val Ser Ala Pro 
145                 150                 155                 160 


Leu Leu Gly Leu Pro Pro Asn Gly Leu Leu Leu Glu Gln Pro Gly Leu 
                165                 170                 175     


Arg Leu Arg Glu Pro Ser Leu Ser Xaa Gln Asn Glu Tyr Asn Glu Ser 
            180                 185                 190         


Ser Glu Ser Glu Val Ser Pro Xaa Pro Tyr Lys Asn Asp Gln Xaa Pro 
        195                 200                 205             


Asn Arg Asn Ala Leu Xaa Ser Ile Xaa Asn Val Glu Pro Lys Xaa Glu 
    210                 215                 220                 


Pro Ala Cys Val Ser Pro Ile Gln Asn Ser Ala Pro Val Ser Asp Leu 
225                 230                 235                 240 


Xaa Lys Xaa Glu His Pro Lys Ser Ser Phe Arg Ile His Arg Met Arg 
                245                 250                 255     


Arg Met Gly Ser Ala Ser Arg Lys Gly Arg Val Phe Cys Asn Ala Cys 
            260                 265                 270         


Gly Lys Xaa Phe Tyr Asp Lys Gly Xaa Leu Lys Ile His Tyr Asn Ala 
        275                 280                 285             


Val His Leu Lys Ile Lys His Arg Cys Xaa Ile Glu Gly Cys Asn Met 
    290                 295                 300                 


Val Phe Ser Ser Leu Arg Ser Arg Asn Arg His Ser Ala Asn Pro Asn 
305                 310                 315                 320 


Pro Arg Leu His Met Pro Met Leu Arg Asn Asn Arg Asp Lys Asp Leu 
                325                 330                 335     


Ile Arg Ala Xaa Ser Gly Ala Ala Xaa Pro Val Ile Ala Ser Xaa Lys 
            340                 345                 350         


Ser Asn Leu Ala Leu Xaa Ser Pro Gly Arg Pro Pro Met Gly Phe Xaa 
        355                 360                 365             


Xaa Pro Pro Leu Asp Pro Val Leu Gln Asn Pro Leu Pro Ser Gln Leu 
    370                 375                 380                 


Val Phe Ser Gly Leu Lys Xaa Val Gln Pro Val Pro Pro Phe Tyr Arg 
385                 390                 395                 400 


Ser Leu Leu Xaa Pro Gly Glu Met Val Ser Pro Pro Xaa Ser Leu Pro 
                405                 410                 415     


Xaa Ser Pro Ile Ile Pro Xaa Ser Gly Xaa Ile Glu Gln His Pro Pro 
            420                 425                 430         


Pro Pro Ser Glu Pro Val Val Pro Ala Val Met Met Ala Xaa His Glu 
        435                 440                 445             


Pro Ser Ala Asp Leu Ala Pro Lys Lys Lys Pro Arg Lys Ser Ser Met 
    450                 455                 460                 


Pro Val Lys Ile Glu Lys Glu Ile Ile Asp Xaa Ala Asp Glu Phe Asp 
465                 470                 475                 480 


Asp Glu Asp Asp Asp Pro Asn Asp Gly Gly Ala Val Val Asn Asp Met 
                485                 490                 495     


Ser His Asp Asn His Cys His Ser Gln Glu Glu Met Ser Pro Gly Met 
            500                 505                 510         


Ser Val Lys Asp Phe Ser Lys His Asn Arg Xaa Arg Cys Ile Ser Arg 
        515                 520                 525             


Xaa Glu Ile Arg Arg Ala Asp Ser Met Xaa Ser Glu Asp Gln Glu Pro 
    530                 535                 540                 


Glu Arg Asp Tyr Glu Asn Glu Ser Glu Ser Ser Glu Pro Lys Leu Gly 
545                 550                 555                 560 


Glu Glu Ser Met Glu Gly Asp Glu His Ile His Ser Glu Val Ser Glu 
                565                 570                 575     


Lys Val Leu Met Asn Ser Glu Arg Pro Asp Glu Asn His Ser Glu Pro 
            580                 585                 590         


Ser His Gln Asp Val Ile Lys Val Lys Glu Glu Phe Xaa Asp Pro Xaa 
        595                 600                 605             


Tyr Asp Met Phe Tyr Met Ser Gln Tyr Gly Leu Tyr Asn Gly Gly Gly 
    610                 615                 620                 


Ala Ser Met Ala Ala Leu His Glu Ser Phe Xaa Ser Ser Leu Asn Tyr 
625                 630                 635                 640 


Gly Ser Pro Gln Lys Phe Ser Pro Glu Gly Asp Leu Cys Ser Ser Pro 
                645                 650                 655     


Asp Pro Lys Ile Cys Tyr Val Cys Lys Lys Ser Phe Lys Ser Ser Tyr 
            660                 665                 670         


Ser Val Lys Leu His Tyr Arg Asn Val His Leu Lys Glu Met His Val 
        675                 680                 685             


Cys Xaa Val Ala Gly Cys Asn Ala Ala Phe Pro Ser Arg Arg Ser Arg 
    690                 695                 700                 


Asp Arg Asn Arg Asn Leu Arg Met Glu Arg Xaa Ile Gly Pro Gly His 
705                 710                 715                 720 


Arg Asp Ser Leu His Leu Leu Pro Xaa 
                725                 


<210> 4299
<211> 40
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<400> 4299
Met Gln Phe Gly Xaa Arg Xaa Xaa Xaa Ala Glu Pro Gly Phe Met Gly 
1               5                   10                  15      


Xaa Trp Gln Asn Ala Asp Xaa Asn Leu Leu Phe Arg Met Ser Gln Gln 
            20                  25                  30          


Ala Ile Arg Cys Xaa Leu Val Asn 
        35                  40  


<210> 4300
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<400> 4300
Met Gln Phe Gly Xaa Arg Xaa Xaa Xaa Ala Glu Pro Gly Phe Met Gly 
1               5                   10                  15      


Xaa Trp Gln Asn Ala Asp Xaa Asn Leu Leu Phe Arg Met Ser Gln Gln 
            20                  25                  30          


Ala Ile Arg Cys Xaa Leu Val Asn Cys Xaa Cys Glu Cys Phe Gln Pro 
        35                  40                  45              


Gly Lys Ile Asn Leu Arg Xaa Cys Asp Gln Cys Lys His Gly Trp Val 
    50                  55                  60                  


Ala His Ala Leu Asp Lys Leu Ser Xaa Gln His Leu Tyr His Pro Xaa 
65                  70                  75                  80  


Gln Val Glu Ile Val Gln Ser Asn Val Val Phe Asp Ile Ser Ser Leu 
                85                  90                  95      


Met Leu Tyr Gly Xaa Gln Ala Val Pro Val Arg Leu Lys Ile Leu Leu 
            100                 105                 110         


Asp Arg Leu Phe Ser Val Leu Lys Gln 
        115                 120     


<210> 4301
<211> 245
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<400> 4301
Met Gln Phe Gly Xaa Arg Xaa Xaa Xaa Ala Glu Pro Gly Phe Met Gly 
1               5                   10                  15      


Xaa Trp Gln Asn Ala Asp Xaa Asn Leu Leu Phe Arg Met Ser Gln Gln 
            20                  25                  30          


Ala Ile Arg Cys Xaa Leu Val Asn Cys Xaa Cys Glu Cys Phe Gln Pro 
        35                  40                  45              


Gly Lys Ile Asn Leu Arg Xaa Cys Asp Gln Cys Lys His Gly Trp Val 
    50                  55                  60                  


Ala His Ala Leu Asp Lys Leu Ser Xaa Gln His Leu Tyr His Pro Xaa 
65                  70                  75                  80  


Gln Val Glu Ile Val Gln Ser Asn Val Val Phe Asp Ile Ser Ser Leu 
                85                  90                  95      


Met Leu Tyr Gly Xaa Gln Ala Val Pro Val Arg Leu Lys Ile Leu Leu 
            100                 105                 110         


Asp Arg Leu Phe Ser Val Leu Lys Gln Glu Glu Val Leu His Ile Leu 
        115                 120                 125             


His Gly Leu Gly Trp Xaa Leu Arg Asp Tyr Val Arg Gly Tyr Ile Leu 
    130                 135                 140                 


Gln Asp Ala Ala Gly Lys Val Leu Asp Arg Trp Ala Ile Met Ser Arg 
145                 150                 155                 160 


Glu Glu Glu Ile Ile Xaa Leu Gln Gln Phe Leu Arg Phe Gly Glu Xaa 
                165                 170                 175     


Lys Ser Ile Val Glu Leu Met Ala Ile Gln Glu Lys Glu Gly Gln Ala 
            180                 185                 190         


Val Ala Val Pro Ser Ser Lys Xaa Asp Ser Asp Ile Arg Xaa Phe Ile 
        195                 200                 205             


Glu Ser Asn Asn Arg Xaa Arg Ser Pro Ser Leu Leu Ala His Leu Glu 
    210                 215                 220                 


Asn Ser Asn Pro Ser Ser Ile His His Phe Glu Asn Ile Pro Asn Ser 
225                 230                 235                 240 


Leu Ala Phe Leu Leu 
                245 


<210> 4302
<211> 295
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<400> 4302
Met Gln Phe Gly Xaa Arg Xaa Xaa Xaa Ala Glu Pro Gly Phe Met Gly 
1               5                   10                  15      


Xaa Trp Gln Asn Ala Asp Xaa Asn Leu Leu Phe Arg Met Ser Gln Gln 
            20                  25                  30          


Ala Ile Arg Cys Xaa Leu Val Asn Cys Xaa Cys Glu Cys Phe Gln Pro 
        35                  40                  45              


Gly Lys Ile Asn Leu Arg Xaa Cys Asp Gln Cys Lys His Gly Trp Val 
    50                  55                  60                  


Ala His Ala Leu Asp Lys Leu Ser Xaa Gln His Leu Tyr His Pro Xaa 
65                  70                  75                  80  


Gln Val Glu Ile Val Gln Ser Asn Val Val Phe Asp Ile Ser Ser Leu 
                85                  90                  95      


Met Leu Tyr Gly Xaa Gln Ala Val Pro Val Arg Leu Lys Ile Leu Leu 
            100                 105                 110         


Asp Arg Leu Phe Ser Val Leu Lys Gln Glu Glu Val Leu His Ile Leu 
        115                 120                 125             


His Gly Leu Gly Trp Xaa Leu Arg Asp Tyr Val Arg Gly Tyr Ile Leu 
    130                 135                 140                 


Gln Asp Ala Ala Gly Lys Val Leu Asp Arg Trp Ala Ile Met Ser Arg 
145                 150                 155                 160 


Glu Glu Glu Ile Ile Xaa Leu Gln Gln Phe Leu Arg Phe Gly Glu Xaa 
                165                 170                 175     


Lys Ser Ile Val Glu Leu Met Ala Ile Gln Glu Lys Glu Gly Gln Ala 
            180                 185                 190         


Val Ala Val Pro Ser Ser Lys Xaa Asp Ser Asp Ile Arg Xaa Phe Ile 
        195                 200                 205             


Glu Ser Asn Asn Arg Xaa Arg Ser Pro Ser Leu Leu Ala His Leu Glu 
    210                 215                 220                 


Asn Ser Asn Pro Ser Ser Ile His His Phe Glu Asn Ile Pro Asn Ser 
225                 230                 235                 240 


Leu Ala Phe Leu Leu Pro Phe Gln Tyr Ile Asn Pro Val Ser Ala Pro 
                245                 250                 255     


Leu Leu Gly Leu Pro Pro Asn Gly Leu Leu Leu Glu Gln Pro Gly Leu 
            260                 265                 270         


Arg Leu Arg Glu Pro Ser Leu Ser Xaa Gln Asn Glu Tyr Asn Glu Ser 
        275                 280                 285             


Ser Glu Ser Glu Val Ser Pro 
    290                 295 


<210> 4303
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<400> 4303
Met Ser Glu Glu Ala Glu Val Asp Val Arg Glu Arg Glu Xaa Gln Arg 
1               5                   10                  15      


Asp Arg Glu Pro Lys Arg Ala Arg Asp Leu Xaa Leu Arg Asp Ser Cys 
            20                  25                  30          


Xaa Asp Asn Ser Met Gln Phe Gly Xaa Arg Xaa Xaa Xaa Ala Glu Pro 
        35                  40                  45              


Gly Phe Met Gly Xaa Trp Gln Asn Ala Asp Xaa Asn Leu Leu Phe Arg 
    50                  55                  60                  


Met Ser Gln Gln Ala Ile Arg Cys Xaa Leu Val Asn Cys Xaa Cys Glu 
65                  70                  75                  80  


Cys Phe Gln Pro Gly Lys Ile Asn Leu Arg Xaa Cys Asp Gln Cys Lys 
                85                  90                  95      


His Gly Trp Val Ala His Ala Leu Asp Lys Leu Ser Xaa Gln His Leu 
            100                 105                 110         


Tyr His Pro Xaa Gln Val Glu Ile Val Gln Ser Asn Val Val Phe Asp 
        115                 120                 125             


Ile Ser Ser Leu Met Leu Tyr Gly Xaa Gln Ala Val Pro Val Arg Leu 
    130                 135                 140                 


Lys Ile Leu Leu Asp Arg Leu Phe Ser Val Leu Lys Gln Glu Glu Val 
145                 150                 155                 160 


Leu His Ile Leu 
                


<210> 4304
<211> 327
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<400> 4304
Pro Ser Glu Pro Val Val Pro Ala Val Met Met Ala Xaa His Glu Pro 
1               5                   10                  15      


Ser Ala Asp Leu Ala Pro Lys Lys Lys Pro Arg Lys Ser Ser Met Pro 
            20                  25                  30          


Val Lys Ile Glu Lys Glu Ile Ile Asp Xaa Ala Asp Glu Phe Asp Asp 
        35                  40                  45              


Glu Asp Asp Asp Pro Asn Asp Gly Gly Ala Val Val Asn Asp Met Ser 
    50                  55                  60                  


His Asp Asn His Cys His Ser Gln Glu Glu Met Ser Pro Gly Met Ser 
65                  70                  75                  80  


Val Lys Asp Phe Ser Lys His Asn Arg Xaa Arg Cys Ile Ser Arg Xaa 
                85                  90                  95      


Glu Ile Arg Arg Ala Asp Ser Met Xaa Ser Glu Asp Gln Glu Pro Glu 
            100                 105                 110         


Arg Asp Tyr Glu Asn Glu Ser Glu Ser Ser Glu Pro Lys Leu Gly Glu 
        115                 120                 125             


Glu Ser Met Glu Gly Asp Glu His Ile His Ser Glu Val Ser Glu Lys 
    130                 135                 140                 


Val Leu Met Asn Ser Glu Arg Pro Asp Glu Asn His Ser Glu Pro Ser 
145                 150                 155                 160 


His Gln Asp Val Ile Lys Val Lys Glu Glu Phe Xaa Asp Pro Xaa Tyr 
                165                 170                 175     


Asp Met Phe Tyr Met Ser Gln Tyr Gly Leu Tyr Asn Gly Gly Gly Ala 
            180                 185                 190         


Ser Met Ala Ala Leu His Glu Ser Phe Xaa Ser Ser Leu Asn Tyr Gly 
        195                 200                 205             


Ser Pro Gln Lys Phe Ser Pro Glu Gly Asp Leu Cys Ser Ser Pro Asp 
    210                 215                 220                 


Pro Lys Ile Cys Tyr Val Cys Lys Lys Ser Phe Lys Ser Ser Tyr Ser 
225                 230                 235                 240 


Val Lys Leu His Tyr Arg Asn Val His Leu Lys Glu Met His Val Cys 
                245                 250                 255     


Xaa Val Ala Gly Cys Asn Ala Ala Phe Pro Ser Arg Arg Ser Arg Asp 
            260                 265                 270         


Arg Asn Arg Asn Leu Arg Met Glu Arg Xaa Ile Gly Pro Gly His Arg 
        275                 280                 285             


Asp Ser Leu His Leu Arg Arg Gly Asn Ser Asn Arg Pro Gly Xaa Cys 
    290                 295                 300                 


Cys Leu His Xaa Gly Asp Ser Leu Glu Glu Ser Val Ile Val Arg Ile 
305                 310                 315                 320 


Ser Cys Lys Arg Leu Glu Ser 
                325         


<210> 4305
<211> 860
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<400> 4305
Ser Glu Glu Ala Glu Val Asp Val Arg Glu Arg Glu Xaa Gln Arg Asp 
1               5                   10                  15      


Arg Glu Pro Lys Arg Ala Arg Asp Leu Xaa Leu Arg Asp Ser Cys Xaa 
            20                  25                  30          


Asp Asn Ser Met Gln Phe Gly Xaa Arg Xaa Xaa Xaa Ala Glu Pro Gly 
        35                  40                  45              


Phe Met Gly Xaa Trp Gln Asn Ala Asp Xaa Asn Leu Leu Phe Arg Met 
    50                  55                  60                  


Ser Gln Gln Ala Ile Arg Cys Xaa Leu Val Asn Cys Xaa Cys Glu Cys 
65                  70                  75                  80  


Phe Gln Pro Gly Lys Ile Asn Leu Arg Xaa Cys Asp Gln Cys Lys His 
                85                  90                  95      


Gly Trp Val Ala His Ala Leu Asp Lys Leu Ser Xaa Gln His Leu Tyr 
            100                 105                 110         


His Pro Xaa Gln Val Glu Ile Val Gln Ser Asn Val Val Phe Asp Ile 
        115                 120                 125             


Ser Ser Leu Met Leu Tyr Gly Xaa Gln Ala Val Pro Val Arg Leu Lys 
    130                 135                 140                 


Ile Leu Leu Asp Arg Leu Phe Ser Val Leu Lys Gln Glu Glu Val Leu 
145                 150                 155                 160 


His Ile Leu His Gly Leu Gly Trp Xaa Leu Arg Asp Tyr Val Arg Gly 
                165                 170                 175     


Tyr Ile Leu Gln Asp Ala Ala Gly Lys Val Leu Asp Arg Trp Ala Ile 
            180                 185                 190         


Met Ser Arg Glu Glu Glu Ile Ile Xaa Leu Gln Gln Phe Leu Arg Phe 
        195                 200                 205             


Gly Glu Xaa Lys Ser Ile Val Glu Leu Met Ala Ile Gln Glu Lys Glu 
    210                 215                 220                 


Gly Gln Ala Val Ala Val Pro Ser Ser Lys Xaa Asp Ser Asp Ile Arg 
225                 230                 235                 240 


Xaa Phe Ile Glu Ser Asn Asn Arg Xaa Arg Ser Pro Ser Leu Leu Ala 
                245                 250                 255     


His Leu Glu Asn Ser Asn Pro Ser Ser Ile His His Phe Glu Asn Ile 
            260                 265                 270         


Pro Asn Ser Leu Ala Phe Leu Leu Pro Phe Gln Tyr Ile Asn Pro Val 
        275                 280                 285             


Ser Ala Pro Leu Leu Gly Leu Pro Pro Asn Gly Leu Leu Leu Glu Gln 
    290                 295                 300                 


Pro Gly Leu Arg Leu Arg Glu Pro Ser Leu Ser Xaa Gln Asn Glu Tyr 
305                 310                 315                 320 


Asn Glu Ser Ser Glu Ser Glu Val Ser Pro Xaa Pro Tyr Lys Asn Asp 
                325                 330                 335     


Gln Xaa Pro Asn Arg Asn Ala Leu Xaa Ser Ile Xaa Asn Val Glu Pro 
            340                 345                 350         


Lys Xaa Glu Pro Ala Cys Val Ser Pro Ile Gln Asn Ser Ala Pro Val 
        355                 360                 365             


Ser Asp Leu Xaa Lys Xaa Glu His Pro Lys Ser Ser Phe Arg Ile His 
    370                 375                 380                 


Arg Met Arg Arg Met Gly Ser Ala Ser Arg Lys Gly Arg Val Phe Cys 
385                 390                 395                 400 


Asn Ala Cys Gly Lys Xaa Phe Tyr Asp Lys Gly Xaa Leu Lys Ile His 
                405                 410                 415     


Tyr Asn Ala Val His Leu Lys Ile Lys His Arg Cys Xaa Ile Glu Gly 
            420                 425                 430         


Cys Asn Met Val Phe Ser Ser Leu Arg Ser Arg Asn Arg His Ser Ala 
        435                 440                 445             


Asn Pro Asn Pro Arg Leu His Met Pro Met Leu Arg Asn Asn Arg Asp 
    450                 455                 460                 


Lys Asp Leu Ile Arg Ala Xaa Ser Gly Ala Ala Xaa Pro Val Ile Ala 
465                 470                 475                 480 


Ser Xaa Lys Ser Asn Leu Ala Leu Xaa Ser Pro Gly Arg Pro Pro Met 
                485                 490                 495     


Gly Phe Xaa Xaa Pro Pro Leu Asp Pro Val Leu Gln Asn Pro Leu Pro 
            500                 505                 510         


Ser Gln Leu Val Phe Ser Gly Leu Lys Xaa Val Gln Pro Val Pro Pro 
        515                 520                 525             


Phe Tyr Arg Ser Leu Leu Xaa Pro Gly Glu Met Val Ser Pro Pro Xaa 
    530                 535                 540                 


Ser Leu Pro Xaa Ser Pro Ile Ile Pro Xaa Ser Gly Xaa Ile Glu Gln 
545                 550                 555                 560 


His Pro Pro Pro Pro Ser Glu Pro Val Val Pro Ala Val Met Met Ala 
                565                 570                 575     


Xaa His Glu Pro Ser Ala Asp Leu Ala Pro Lys Lys Lys Pro Arg Lys 
            580                 585                 590         


Ser Ser Met Pro Val Lys Ile Glu Lys Glu Ile Ile Asp Xaa Ala Asp 
        595                 600                 605             


Glu Phe Asp Asp Glu Asp Asp Asp Pro Asn Asp Gly Gly Ala Val Val 
    610                 615                 620                 


Asn Asp Met Ser His Asp Asn His Cys His Ser Gln Glu Glu Met Ser 
625                 630                 635                 640 


Pro Gly Met Ser Val Lys Asp Phe Ser Lys His Asn Arg Xaa Arg Cys 
                645                 650                 655     


Ile Ser Arg Xaa Glu Ile Arg Arg Ala Asp Ser Met Xaa Ser Glu Asp 
            660                 665                 670         


Gln Glu Pro Glu Arg Asp Tyr Glu Asn Glu Ser Glu Ser Ser Glu Pro 
        675                 680                 685             


Lys Leu Gly Glu Glu Ser Met Glu Gly Asp Glu His Ile His Ser Glu 
    690                 695                 700                 


Val Ser Glu Lys Val Leu Met Asn Ser Glu Arg Pro Asp Glu Asn His 
705                 710                 715                 720 


Ser Glu Pro Ser His Gln Asp Val Ile Lys Val Lys Glu Glu Phe Xaa 
                725                 730                 735     


Asp Pro Xaa Tyr Asp Met Phe Tyr Met Ser Gln Tyr Gly Leu Tyr Asn 
            740                 745                 750         


Gly Gly Gly Ala Ser Met Ala Ala Leu His Glu Ser Phe Xaa Ser Ser 
        755                 760                 765             


Leu Asn Tyr Gly Ser Pro Gln Lys Phe Ser Pro Glu Gly Asp Leu Cys 
    770                 775                 780                 


Ser Ser Pro Asp Pro Lys Ile Cys Tyr Val Cys Lys Lys Ser Phe Lys 
785                 790                 795                 800 


Ser Ser Tyr Ser Val Lys Leu His Tyr Arg Asn Val His Leu Lys Glu 
                805                 810                 815     


Met His Val Cys Xaa Val Ala Gly Cys Asn Ala Ala Phe Pro Ser Arg 
            820                 825                 830         


Arg Ser Arg Asp Arg Asn Arg Asn Leu Arg Met Glu Arg Xaa Ile Gly 
        835                 840                 845             


Pro Gly His Arg Asp Ser Leu His Leu Leu Pro Xaa 
    850                 855                 860 


<210> 4306
<211> 109
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 4306
Ser Glu Glu Ala Glu Val Asp Val Arg Glu Arg Glu Xaa Gln Arg Asp 
1               5                   10                  15      


Arg Glu Pro Lys Arg Ala Arg Asp Leu Xaa Leu Arg Asp Ser Cys Xaa 
            20                  25                  30          


Asp Asn Ser Met Gln Phe Gly Xaa Arg Xaa Xaa Xaa Ala Glu Pro Gly 
        35                  40                  45              


Phe Met Gly Xaa Trp Gln Asn Ala Asp Xaa Asn Leu Leu Phe Arg Met 
    50                  55                  60                  


Ser Gln Gln Ala Ile Arg Cys Xaa Leu Val Asn Cys Xaa Cys Glu Cys 
65                  70                  75                  80  


Phe Gln Pro Gly Lys Ile Asn Leu Arg Xaa Cys Asp Gln Cys Lys His 
                85                  90                  95      


Gly Trp Val Ala His Glu Xaa Leu Lys Ser Cys Leu Gln 
            100                 105                 


<210> 4307
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<400> 4307
Glu Lys Glu Asp Gly Arg Arg Trp Arg Met Phe Arg Ile Gly Glu Gln 
1               5                   10                  15      


Asp His Arg Val Asp Met Lys Ala Ile Glu Pro Tyr Lys Lys Val Ile 
            20                  25                  30          


Ser His Gly Gly Tyr Tyr Gly Asp Gly Leu Asn Ala Ile Val Val Phe 
        35                  40                  45              


Ala Val Cys Phe Met Pro Glu Ser Ser Gln Pro Asn Tyr Arg Tyr Leu 
    50                  55                  60                  


Met Asp Asn Leu Phe Lys Tyr Val Ile Gly Xaa Leu Glu Leu Leu Val 
65                  70                  75                  80  


Ala Glu Asn Tyr Met Ile Val Tyr Leu Asn Gly Ala Xaa Xaa Arg Arg 
                85                  90                  95      


Lys Met Pro Ser Leu Gly Trp Leu Arg Lys Cys Tyr Gln Gln Ile Asp 
            100                 105                 110         


Arg Arg Leu Arg Lys Asn Leu Lys Ser Leu Ile Ile Val His Pro Ser 
        115                 120                 125             


Trp Phe Ile Arg Xaa Leu Leu Ala Val Xaa Arg Pro Phe Ile Ser Ser 
    130                 135                 140                 


Lys Phe Ser Gln Lys Ile Arg Tyr Val Phe Asn Leu Ala Glu Leu Ala 
145                 150                 155                 160 


Glu Leu Val Pro Met Glu Tyr Val Gly Ile Pro Glu Cys Ile Lys Gln 
                165                 170                 175     


Tyr Glu Glu Glu Lys Phe Lys Lys Lys Gln Lys Arg Val Asp Gln Glu 
            180                 185                 190         


Leu Asn Gly Lys Gln Asp Glu Pro Lys Asn Glu Gln 
        195                 200                 


<210> 4308
<211> 314
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<400> 4308
Met Glu Gly Val Glu Leu Lys Glu Glu Trp Gln Asp Glu Asp Phe Pro 
1               5                   10                  15      


Ile Pro Leu Pro Glu Asp Asp Ser Ile Glu Ala Asp Ile Leu Ala Ile 
            20                  25                  30          


Xaa Gly Pro Glu Asp Gln Pro Gly Ser Leu Glu Val Asn Gly Asn Lys 
        35                  40                  45              


Val Arg Lys Lys Leu Met Ala Pro Asp Ile Ser Leu Xaa Leu Asp Pro 
    50                  55                  60                  


Ser Asp Gly Ser Val Leu Ser Asp Asp Leu Asp Glu Ser Gly Glu Ile 
65                  70                  75                  80  


Asp Leu Asp Gly Leu Asp Xaa Pro Ser Glu Asn Ser Asn Glu Phe Glu 
                85                  90                  95      


Trp Glu Asp Asp Leu Pro Lys Pro Lys Xaa Xaa Glu Val Ile Arg Lys 
            100                 105                 110         


Gly Ser Ile Xaa Glu Tyr Xaa Ala Ala Glu Glu Lys Glu Asp Gly Arg 
        115                 120                 125             


Arg Trp Arg Met Phe Arg Ile Gly Glu Gln Asp His Arg Val Asp Met 
    130                 135                 140                 


Lys Ala Ile Glu Pro Tyr Lys Lys Val Ile Ser His Gly Gly Tyr Tyr 
145                 150                 155                 160 


Gly Asp Gly Leu Asn Ala Ile Val Val Phe Ala Val Cys Phe Met Pro 
                165                 170                 175     


Glu Ser Ser Gln Pro Asn Tyr Arg Tyr Leu Met Asp Asn Leu Phe Lys 
            180                 185                 190         


Tyr Val Ile Gly Xaa Leu Glu Leu Leu Val Ala Glu Asn Tyr Met Ile 
        195                 200                 205             


Val Tyr Leu Asn Gly Ala Xaa Xaa Arg Arg Lys Met Pro Ser Leu Gly 
    210                 215                 220                 


Trp Leu Arg Lys Cys Tyr Gln Gln Ile Asp Arg Arg Leu Arg Lys Asn 
225                 230                 235                 240 


Leu Lys Ser Leu Ile Ile Val His Pro Ser Trp Phe Ile Arg Xaa Leu 
                245                 250                 255     


Leu Ala Val Xaa Arg Pro Phe Ile Ser Ser Lys Phe Ser Gln Lys Ile 
            260                 265                 270         


Arg Tyr Val Phe Asn Leu Ala Glu Leu Ala Glu Leu Val Pro Met Glu 
        275                 280                 285             


Tyr Val Gly Ile Pro Glu Cys Ile Lys Gln Val Asp Gln Glu Leu Asn 
    290                 295                 300                 


Gly Lys Gln Asp Glu Pro Lys Asn Glu Gln 
305                 310                 


<210> 4309
<211> 376
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<400> 4309
Met Glu Pro Cys Pro Ser Ser Ala Pro Pro Pro Phe Tyr Pro Gly Val 
1               5                   10                  15      


Gly Glu Val Ala Gly Leu Arg Trp Phe Ser Ile Tyr Asp Gln Arg Pro 
            20                  25                  30          


Ser Trp Tyr Arg Xaa Lys Lys Leu Gly Leu Leu Asp Ile Gly Ser Leu 
        35                  40                  45              


Asp Tyr Gln Glu Phe Val Val Asp Ile Glu Ser Arg Leu Arg Met Glu 
    50                  55                  60                  


Gly Val Glu Leu Lys Glu Glu Trp Gln Asp Glu Asp Phe Pro Ile Pro 
65                  70                  75                  80  


Leu Pro Glu Asp Asp Ser Ile Glu Ala Asp Ile Leu Ala Ile Xaa Gly 
                85                  90                  95      


Pro Glu Asp Gln Pro Gly Ser Leu Glu Val Asn Gly Asn Lys Val Arg 
            100                 105                 110         


Lys Lys Leu Met Ala Pro Asp Ile Ser Leu Xaa Leu Asp Pro Ser Asp 
        115                 120                 125             


Gly Ser Val Leu Ser Asp Asp Leu Asp Glu Ser Gly Glu Ile Asp Leu 
    130                 135                 140                 


Asp Gly Leu Asp Xaa Pro Ser Glu Asn Ser Asn Glu Phe Glu Trp Glu 
145                 150                 155                 160 


Asp Asp Leu Pro Lys Pro Lys Xaa Xaa Glu Val Ile Arg Lys Gly Ser 
                165                 170                 175     


Ile Xaa Glu Tyr Xaa Ala Ala Glu Glu Lys Glu Asp Gly Arg Arg Trp 
            180                 185                 190         


Arg Met Phe Arg Ile Gly Glu Gln Asp His Arg Val Asp Met Lys Ala 
        195                 200                 205             


Ile Glu Pro Tyr Lys Lys Val Ile Ser His Gly Gly Tyr Tyr Gly Asp 
    210                 215                 220                 


Gly Leu Asn Ala Ile Val Val Phe Ala Val Cys Phe Met Pro Glu Ser 
225                 230                 235                 240 


Ser Gln Pro Asn Tyr Arg Tyr Leu Met Asp Asn Leu Phe Lys Tyr Val 
                245                 250                 255     


Ile Gly Xaa Leu Glu Leu Leu Val Ala Glu Asn Tyr Met Ile Val Tyr 
            260                 265                 270         


Leu Asn Gly Ala Xaa Xaa Arg Arg Lys Met Pro Ser Leu Gly Trp Leu 
        275                 280                 285             


Arg Lys Cys Tyr Gln Gln Ile Asp Arg Arg Leu Arg Lys Asn Leu Lys 
    290                 295                 300                 


Ser Leu Ile Ile Val His Pro Ser Trp Phe Ile Arg Xaa Leu Leu Ala 
305                 310                 315                 320 


Val Xaa Arg Pro Phe Ile Ser Ser Lys Phe Ser Gln Lys Ile Arg Tyr 
                325                 330                 335     


Val Phe Asn Leu Ala Glu Leu Ala Glu Leu Val Pro Met Glu Tyr Val 
            340                 345                 350         


Gly Ile Pro Glu Cys Ile Lys Gln Val Asp Gln Glu Leu Asn Gly Lys 
        355                 360                 365             


Gln Asp Glu Pro Lys Asn Glu Gln 
    370                 375     


<210> 4310
<211> 435
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<400> 4310
Met Leu Cys Gly Phe Gln Glu Asp Ala Xaa Pro Pro Pro Pro Pro Arg 
1               5                   10                  15      


Pro Arg Arg Leu His Arg Arg Leu Pro Arg Pro Glu Glu Val Gly Met 
            20                  25                  30          


Leu Ser Leu Pro Pro Gly Leu Leu Xaa Val Ser Gly Ser Ala Ala Ala 
        35                  40                  45              


Ala Asp Ala Val Pro Leu Arg Pro Gly Asp Trp Ala Gly Val Ser Xaa 
    50                  55                  60                  


Ala Asp Arg Gly Glu Arg Ala Pro Leu Gly Pro Ala Phe Cys Asp Leu 
65                  70                  75                  80  


Ala Val Ser Pro Xaa Ser Pro Ala Trp Arg Gly Glu Glu Asp Glu Gly 
                85                  90                  95      


Ala Lys Ala Ser Ser Gly Asp Ile Gly Ser Leu Asp Tyr Gln Glu Phe 
            100                 105                 110         


Val Val Asp Ile Glu Ser Arg Leu Arg Met Glu Gly Val Glu Leu Lys 
        115                 120                 125             


Glu Glu Trp Gln Asp Glu Asp Phe Pro Ile Pro Leu Pro Glu Asp Asp 
    130                 135                 140                 


Ser Ile Glu Ala Asp Ile Leu Ala Ile Xaa Gly Pro Glu Asp Gln Pro 
145                 150                 155                 160 


Gly Ser Leu Glu Val Asn Gly Asn Lys Val Arg Lys Lys Leu Met Ala 
                165                 170                 175     


Pro Asp Ile Ser Leu Xaa Leu Asp Pro Ser Asp Gly Ser Val Leu Ser 
            180                 185                 190         


Asp Asp Leu Asp Glu Ser Gly Glu Ile Asp Leu Asp Gly Leu Asp Xaa 
        195                 200                 205             


Pro Ser Glu Asn Ser Asn Glu Phe Glu Trp Glu Asp Asp Leu Pro Lys 
    210                 215                 220                 


Pro Lys Xaa Xaa Glu Val Ile Arg Lys Gly Ser Ile Xaa Glu Tyr Xaa 
225                 230                 235                 240 


Ala Ala Glu Glu Lys Glu Asp Gly Arg Arg Trp Arg Met Phe Arg Ile 
                245                 250                 255     


Gly Glu Gln Asp His Arg Val Asp Met Lys Ala Ile Glu Pro Tyr Lys 
            260                 265                 270         


Lys Val Ile Ser His Gly Gly Tyr Tyr Gly Asp Gly Leu Asn Ala Ile 
        275                 280                 285             


Val Val Phe Ala Val Cys Phe Met Pro Glu Ser Ser Gln Pro Asn Tyr 
    290                 295                 300                 


Arg Tyr Leu Met Asp Asn Leu Phe Lys Tyr Val Ile Gly Xaa Leu Glu 
305                 310                 315                 320 


Leu Leu Val Ala Glu Asn Tyr Met Ile Val Tyr Leu Asn Gly Ala Xaa 
                325                 330                 335     


Xaa Arg Arg Lys Met Pro Ser Leu Gly Trp Leu Arg Lys Cys Tyr Gln 
            340                 345                 350         


Gln Ile Asp Arg Arg Leu Arg Lys Asn Leu Lys Ser Leu Ile Ile Val 
        355                 360                 365             


His Pro Ser Trp Phe Ile Arg Xaa Leu Leu Ala Val Xaa Arg Pro Phe 
    370                 375                 380                 


Ile Ser Ser Lys Phe Ser Gln Lys Ile Arg Tyr Val Phe Asn Leu Ala 
385                 390                 395                 400 


Glu Leu Ala Glu Leu Val Pro Met Glu Tyr Val Gly Ile Pro Glu Cys 
                405                 410                 415     


Ile Lys Gln Val Asp Gln Glu Leu Asn Gly Lys Gln Asp Glu Pro Lys 
            420                 425                 430         


Asn Glu Gln 
        435 


<210> 4311
<211> 87
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<400> 4311
Xaa Asp Asp Ser Ile Glu Ala Asp Ile Leu Ala Ile Xaa Gly Pro Glu 
1               5                   10                  15      


Asp Gln Pro Gly Ser Leu Glu Val Asn Gly Asn Lys Val Arg Lys Lys 
            20                  25                  30          


Leu Met Ala Pro Asp Ile Ser Leu Xaa Leu Asp Pro Ser Asp Gly Ser 
        35                  40                  45              


Val Leu Ser Asp Asp Leu Asp Glu Ser Gly Glu Ile Asp Leu Asp Gly 
    50                  55                  60                  


Leu Asp Xaa Pro Ser Glu Asn Ser Asn Glu Phe Glu Trp Glu Val Ile 
65                  70                  75                  80  


Ser Trp Lys Asp Ile Phe Arg 
                85          


<210> 4312
<211> 259
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<400> 4312
Met Gly Asp Ala Ala Ala Asp Pro Pro Gly Pro Ala Leu Pro Cys Glu 
1               5                   10                  15      


Phe Leu Arg Pro Gly Cys Gly Ala Pro Leu Ser Pro Gly Ala Gln Leu 
            20                  25                  30          


Gly Arg Gly Ala Pro Xaa Ser Ala Phe Pro Pro Pro Ala Ala Glu Ala 
        35                  40                  45              


His Pro Ala Ala Arg Arg Gly Leu Arg Ser Pro Gln Leu Pro Ser Gly 
    50                  55                  60                  


Ala Met Ser Gln Asn Gly Ala Pro Gly Met Gln Glu Glu Ser Leu Gln 
65                  70                  75                  80  


Gly Ser Trp Val Glu Leu His Phe Ser Asn Asn Gly Asn Gly Gly Ser 
                85                  90                  95      


Val Pro Ala Ser Val Ser Ile Tyr Asn Gly Asp Met Glu Lys Ile Leu 
            100                 105                 110         


Leu Asp Ala Gln His Glu Ser Gly Arg Ser Ser Ser Lys Ser Ser His 
        115                 120                 125             


Cys Asp Ser Pro Pro Arg Ser Gln Xaa Pro Gln Asp Xaa Asn Arg Ala 
    130                 135                 140                 


Ser Glu Xaa Asp Xaa His Ser Ile Gly Glu Lys Asn Ser Ser Gln Ser 
145                 150                 155                 160 


Glu Glu Asp Asp Ile Glu Arg Arg Lys Glu Val Glu Ser Ile Leu Lys 
                165                 170                 175     


Lys Asn Ser Asp Trp Ile Trp Asp Trp Ser Ser Arg Pro Glu Asn Ile 
            180                 185                 190         


Pro Pro Lys Glu Phe Leu Phe Lys His Pro Lys Arg Xaa Ala Xaa Leu 
        195                 200                 205             


Ser Met Arg Asn Xaa Ser Val Met Lys Lys Gly Gly Ile Phe Ser Ala 
    210                 215                 220                 


Glu Phe Leu Lys Val Phe Leu Pro Ser Leu Leu Leu Ser His Leu Leu 
225                 230                 235                 240 


Ala Ile Gly Leu Gly Ile Tyr Ile Gly Arg Arg Leu Xaa Xaa Ser Xaa 
                245                 250                 255     


Ser Xaa Phe 
            


<210> 4313
<211> 219
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<400> 4313
Ser Pro Gly Ala Gln Leu Gly Arg Gly Ala Pro Xaa Ser Ala Phe Pro 
1               5                   10                  15      


Pro Pro Ala Ala Glu Ala His Pro Ala Ala Arg Arg Gly Leu Arg Ser 
            20                  25                  30          


Pro Gln Leu Pro Ser Gly Ala Met Ser Gln Asn Gly Ala Pro Gly Met 
        35                  40                  45              


Gln Glu Glu Ser Leu Gln Gly Ser Trp Val Glu Leu His Phe Ser Asn 
    50                  55                  60                  


Asn Gly Asn Gly Gly Ser Val Pro Ala Ser Val Ser Ile Tyr Asn Gly 
65                  70                  75                  80  


Asp Met Glu Lys Ile Leu Leu Asp Ala Gln His Glu Ser Gly Arg Ser 
                85                  90                  95      


Ser Ser Lys Ser Ser His Cys Asp Ser Pro Pro Arg Ser Gln Xaa Pro 
            100                 105                 110         


Gln Asp Xaa Asn Arg Ala Ser Glu Xaa Asp Xaa His Ser Ile Gly Glu 
        115                 120                 125             


Lys Asn Ser Ser Gln Ser Glu Glu Asp Asp Ile Glu Arg Arg Lys Glu 
    130                 135                 140                 


Val Glu Ser Ile Leu Lys Lys Asn Ser Asp Trp Ile Trp Asp Trp Ser 
145                 150                 155                 160 


Ser Arg Pro Glu Asn Ile Pro Pro Lys Glu Phe Leu Phe Lys His Pro 
                165                 170                 175     


Lys Arg Xaa Ala Xaa Leu Ser Met Arg Asn Xaa Ser Val Met Lys Lys 
            180                 185                 190         


Gly Gly Ile Phe Ser Ala Glu Phe Leu Lys Val Phe Leu Pro Ser Leu 
        195                 200                 205             


Leu Leu Ser His Leu Leu Ala Ile Gly Leu Gly 
    210                 215                 


<210> 4314
<211> 243
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<400> 4314
Xaa Leu Pro Cys Glu Phe Leu Arg Pro Gly Cys Gly Ala Pro Leu Ser 
1               5                   10                  15      


Pro Gly Ala Gln Leu Gly Arg Gly Ala Pro Xaa Ser Ala Phe Pro Pro 
            20                  25                  30          


Pro Ala Ala Glu Ala His Pro Ala Ala Arg Arg Gly Leu Arg Ser Pro 
        35                  40                  45              


Gln Leu Pro Ser Gly Ala Met Ser Gln Asn Gly Ala Pro Gly Met Gln 
    50                  55                  60                  


Glu Glu Ser Leu Gln Gly Ser Trp Val Glu Leu His Phe Ser Asn Asn 
65                  70                  75                  80  


Gly Asn Gly Gly Ser Val Pro Ala Ser Val Ser Ile Tyr Asn Gly Asp 
                85                  90                  95      


Met Glu Lys Ile Leu Leu Asp Ala Gln His Glu Ser Gly Arg Ser Ser 
            100                 105                 110         


Ser Lys Ser Ser His Cys Asp Ser Pro Pro Arg Ser Gln Xaa Pro Gln 
        115                 120                 125             


Asp Xaa Asn Arg Ala Ser Glu Xaa Asp Xaa His Ser Ile Gly Glu Lys 
    130                 135                 140                 


Asn Ser Ser Gln Ser Glu Glu Asp Asp Ile Glu Arg Arg Lys Glu Val 
145                 150                 155                 160 


Glu Ser Ile Leu Lys Lys Asn Ser Asp Trp Ile Trp Asp Trp Ser Ser 
                165                 170                 175     


Arg Pro Glu Asn Ile Pro Pro Lys Glu Phe Leu Phe Lys His Pro Lys 
            180                 185                 190         


Arg Xaa Ala Xaa Leu Ser Met Arg Asn Xaa Ser Val Met Lys Lys Gly 
        195                 200                 205             


Gly Ile Phe Ser Ala Glu Phe Leu Lys Val Phe Leu Pro Ser Leu Leu 
    210                 215                 220                 


Leu Ser His Leu Leu Ala Ile Gly Leu Gly Asp Gly Ala Ser Pro Arg 
225                 230                 235                 240 


Cys Pro Gly 
            


<210> 4315
<211> 22
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<400> 4315
Met Leu Arg Gly Xaa Met Xaa Ala Trp Arg Gly Met Arg Pro Glu Val 
1               5                   10                  15      


Xaa Leu Ala Cys Leu Leu 
            20          


<210> 4316
<211> 32
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<400> 4316
Met Leu Arg Gly Xaa Met Xaa Ala Trp Arg Gly Met Arg Pro Glu Val 
1               5                   10                  15      


Xaa Leu Ala Cys Leu Leu Leu Ala Xaa Ala Gly Cys Phe Ala Asp Leu 
            20                  25                  30          


<210> 4317
<211> 85
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<400> 4317
Met Leu Arg Gly Xaa Met Xaa Ala Trp Arg Gly Met Arg Pro Glu Val 
1               5                   10                  15      


Xaa Leu Ala Cys Leu Leu Leu Ala Xaa Ala Gly Cys Phe Ala Asp Leu 
            20                  25                  30          


Asn Glu Val Pro Gln Val Xaa Val Gln Pro Ala Ser Xaa Val Gln Lys 
        35                  40                  45              


Pro Gly Gly Xaa Val Ile Leu Gly Cys Val Val Glu Pro Pro Arg Met 
    50                  55                  60                  


Asn Val Xaa Trp Arg Leu Asn Gly Lys Glu Leu Asn Gly Ser Asp Asp 
65                  70                  75                  80  


Ala Leu Gly Val Leu 
                85  


<210> 4318
<211> 1114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<400> 4318
Met Leu Arg Gly Xaa Met Xaa Ala Trp Arg Gly Met Arg Pro Glu Val 
1               5                   10                  15      


Xaa Leu Ala Cys Leu Leu Leu Ala Xaa Ala Gly Cys Phe Ala Asp Leu 
            20                  25                  30          


Asn Glu Val Pro Gln Val Xaa Val Gln Pro Ala Ser Xaa Val Gln Lys 
        35                  40                  45              


Pro Gly Gly Xaa Val Ile Leu Gly Cys Val Val Glu Pro Pro Arg Met 
    50                  55                  60                  


Asn Val Xaa Trp Arg Leu Asn Gly Lys Glu Leu Asn Gly Ser Asp Asp 
65                  70                  75                  80  


Ala Leu Gly Val Leu Ile Xaa His Gly Xaa Leu Val Ile Xaa Ala Leu 
                85                  90                  95      


Asn Asn His Xaa Val Gly Arg Tyr Gln Cys Val Ala Arg Met Pro Ala 
            100                 105                 110         


Gly Ala Val Ala Ser Val Pro Ala Xaa Val Xaa Leu Ala Asn Leu Gln 
        115                 120                 125             


Asp Phe Lys Leu Asp Val Gln His Val Ile Glu Val Asp Glu Gly Asn 
    130                 135                 140                 


Xaa Ala Val Ile Ala Cys His Leu Pro Glu Ser His Pro Lys Ala Gln 
145                 150                 155                 160 


Val Arg Tyr Ser Val Lys Gln Glu Trp Leu Glu Ala Ser Arg Gly Asn 
                165                 170                 175     


Tyr Leu Ile Met Pro Ser Gly Asn Leu Gln Ile Val Asn Ala Ser Gln 
            180                 185                 190         


Glu Asp Glu Gly Met Tyr Lys Cys Ala Ala Tyr Asn Pro Val Xaa Gln 
        195                 200                 205             


Glu Val Lys Xaa Ser Gly Ser Ser Asp Arg Leu Arg Val Arg Arg Ser 
    210                 215                 220                 


Xaa Ala Glu Ala Ala Arg Ile Ile Tyr Pro Pro Glu Ala Gln Xaa Ile 
225                 230                 235                 240 


Ile Val Xaa Lys Gly Gln Ser Leu Ile Leu Glu Cys Val Ala Ser Gly 
                245                 250                 255     


Ile Pro Pro Pro Arg Val Xaa Trp Ala Lys Asp Gly Ser Ser Val Xaa 
            260                 265                 270         


Gly Tyr Asn Lys Xaa Arg Phe Leu Leu Ser Asn Leu Leu Ile Asp Xaa 
        275                 280                 285             


Xaa Ser Glu Glu Asp Ser Gly Xaa Tyr Arg Cys Met Ala Asp Asn Gly 
    290                 295                 300                 


Val Gly Gln Pro Gly Ala Ala Val Ile Leu Tyr Asn Val Gln Val Phe 
305                 310                 315                 320 


Glu Pro Pro Glu Val Xaa Met Glu Leu Ser Gln Leu Val Ile Pro Trp 
                325                 330                 335     


Gly Gln Ser Ala Lys Leu Xaa Cys Glu Val Arg Gly Asn Pro Pro Pro 
            340                 345                 350         


Ser Val Leu Trp Leu Arg Asn Ala Val Pro Leu Ile Ser Ser Gln Arg 
        355                 360                 365             


Leu Arg Leu Ser Arg Arg Ala Leu Arg Val Leu Ser Met Gly Pro Glu 
    370                 375                 380                 


Asp Glu Gly Val Tyr Gln Cys Met Ala Glu Asn Glu Val Gly Ser Ala 
385                 390                 395                 400 


His Ala Val Val Gln Leu Arg Xaa Ser Arg Pro Ser Ile Xaa Pro Arg 
                405                 410                 415     


Leu Trp Gln Asp Ala Glu Leu Ala Xaa Gly Xaa Pro Pro Val Ser Pro 
            420                 425                 430         


Ser Lys Leu Gly Asn Pro Glu Gln Met Leu Arg Gly Gln Pro Ala Leu 
        435                 440                 445             


Pro Arg Pro Pro Xaa Ser Val Gly Pro Ala Ser Pro Gln Cys Pro Gly 
    450                 455                 460                 


Glu Lys Gly Gln Gly Ala Pro Ala Glu Ala Pro Ile Ile Leu Ser Ser 
465                 470                 475                 480 


Pro Arg Xaa Ser Lys Xaa Asp Ser Tyr Glu Leu Val Trp Arg Pro Arg 
                485                 490                 495     


His Glu Gly Ser Gly Arg Ala Pro Ile Leu Tyr Tyr Val Val Lys His 
            500                 505                 510         


Arg Lys Val Xaa Asn Ser Ser Asp Asp Trp Xaa Ile Ser Gly Ile Pro 
        515                 520                 525             


Ala Asn Gln His Arg Leu Xaa Leu Xaa Arg Leu Asp Pro Gly Ser Leu 
    530                 535                 540                 


Tyr Glu Val Glu Met Ala Ala Tyr Asn Cys Ala Gly Glu Gly Gln Xaa 
545                 550                 555                 560 


Ala Met Val Xaa Phe Arg Xaa Gly Arg Arg Pro Lys Pro Glu Ile Met 
                565                 570                 575     


Ala Ser Lys Glu Gln Gln Ile Gln Arg Asp Asp Pro Gly Ala Ser Pro 
            580                 585                 590         


Gln Ser Ser Ser Gln Pro Asp His Gly Arg Leu Ser Pro Pro Glu Ala 
        595                 600                 605             


Pro Asp Arg Pro Xaa Ile Ser Xaa Ala Ser Glu Xaa Ser Val Tyr Val 
    610                 615                 620                 


Xaa Trp Ile Pro Arg Gly Asn Gly Gly Phe Pro Ile Gln Ser Phe Arg 
625                 630                 635                 640 


Val Glu Tyr Lys Lys Leu Lys Lys Val Gly Asp Trp Ile Leu Ala Xaa 
                645                 650                 655     


Ser Ala Ile Pro Pro Ser Arg Leu Ser Val Glu Ile Xaa Gly Leu Glu 
            660                 665                 670         


Lys Gly Xaa Ser Tyr Lys Phe Arg Val Arg Ala Leu Asn Met Leu Gly 
        675                 680                 685             


Glu Ser Glu Pro Ser Ala Pro Ser Arg Pro Tyr Val Val Ser Gly Tyr 
    690                 695                 700                 


Ser Gly Arg Val Tyr Glu Arg Pro Val Ala Gly Pro Tyr Ile Xaa Phe 
705                 710                 715                 720 


Xaa Asp Ala Val Asn Glu Xaa Xaa Ile Met Leu Lys Trp Met Tyr Ile 
                725                 730                 735     


Pro Ala Ser Asn Asn Asn Xaa Pro Ile His Gly Phe Tyr Ile Tyr Tyr 
            740                 745                 750         


Arg Pro Xaa Asp Ser Asp Asn Asp Ser Asp Tyr Lys Lys Asp Met Val 
        755                 760                 765             


Glu Gly Asp Lys Tyr Trp His Ser Ile Ser His Leu Gln Pro Glu Xaa 
    770                 775                 780                 


Ser Tyr Asp Ile Lys Met Gln Cys Phe Asn Glu Gly Gly Glu Ser Glu 
785                 790                 795                 800 


Phe Ser Asn Val Met Ile Cys Glu Xaa Lys Ala Arg Lys Ser Ser Gly 
                805                 810                 815     


Gln Pro Gly Arg Leu Pro Pro Pro Xaa Leu Ala Pro Pro Gln Pro Pro 
            820                 825                 830         


Leu Pro Glu Xaa Ile Glu Arg Pro Val Gly Xaa Gly Ala Met Val Ala 
        835                 840                 845             


Arg Ser Ser Asp Leu Pro Tyr Leu Ile Val Gly Val Val Leu Gly Ser 
    850                 855                 860                 


Ile Val Leu Ile Ile Val Xaa Phe Ile Pro Phe Cys Leu Trp Arg Ala 
865                 870                 875                 880 


Trp Ser Lys Gln Lys His Xaa Xaa Asp Leu Gly Phe Pro Arg Ser Ala 
                885                 890                 895     


Leu Pro Pro Ser Cys Pro Tyr Xaa Met Val Pro Leu Gly Gly Leu Pro 
            900                 905                 910         


Gly His Gln Ala Ser Gly Gln Pro Tyr Leu Ser Gly Ile Ser Gly Arg 
        915                 920                 925             


Ala Cys Ala Asn Gly Ile His Met Asn Arg Gly Cys Pro Ser Ala Ala 
    930                 935                 940                 


Val Gly Tyr Pro Gly Met Lys Pro Gln Gln His Cys Pro Gly Glu Leu 
945                 950                 955                 960 


Gln Gln Gln Ser Asp Xaa Ser Ser Leu Leu Arg Gln Xaa His Leu Gly 
                965                 970                 975     


Asn Gly Tyr Asp Pro Gln Ser His Gln Ile Xaa Arg Gly Pro Lys Ser 
            980                 985                 990         


Ser Pro Asp Glu Gly Ser Phe Leu  Tyr Xaa Leu Pro Asp  Asp Ser Xaa 
        995                 1000                 1005             


His Gln  Leu Leu Gln Pro His  His Asp Cys Cys Gln  Arg Gln Glu 
    1010                 1015                 1020             


Gln Pro  Ala Ala Val Gly Gln  Ser Gly Val Arg Arg  Ala Pro Asp 
    1025                 1030                 1035             


Ser Pro  Val Leu Glu Ala Val  Trp Asp Pro Pro Phe  His Ser Gly 
    1040                 1045                 1050             


Pro Pro  Cys Cys Leu Gly Leu  Val Pro Val Glu Glu  Val Asp Ser 
    1055                 1060                 1065             


Pro Asp  Ser Cys Gln Val Ser  Gly Gly Asp Trp Cys  Pro Gln His 
    1070                 1075                 1080             


Pro Val  Gly Ala Tyr Val Gly  Gln Glu Pro Gly Met  Gln Leu Ser 
    1085                 1090                 1095             


Pro Gly  Pro Leu Val Arg Val  Ser Phe Glu Xaa Pro  Pro Leu Xaa 
    1100                 1105                 1110             


Ile 
    


<210> 4319
<211> 1115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<400> 4319
Met Leu Arg Gly Xaa Met Xaa Ala Trp Arg Gly Met Arg Pro Glu Val 
1               5                   10                  15      


Xaa Leu Ala Cys Leu Leu Leu Ala Xaa Ala Gly Cys Phe Ala Asp Leu 
            20                  25                  30          


Asn Glu Val Pro Gln Val Xaa Val Gln Pro Ala Ser Xaa Val Gln Lys 
        35                  40                  45              


Pro Gly Gly Xaa Val Ile Leu Gly Cys Val Val Glu Pro Pro Arg Met 
    50                  55                  60                  


Asn Val Xaa Trp Arg Leu Asn Gly Lys Glu Leu Asn Gly Ser Asp Asp 
65                  70                  75                  80  


Ala Leu Gly Val Leu Ile Xaa His Gly Xaa Leu Val Ile Xaa Ala Leu 
                85                  90                  95      


Asn Asn His Xaa Val Gly Arg Tyr Gln Cys Val Ala Arg Met Pro Ala 
            100                 105                 110         


Gly Ala Val Ala Ser Val Pro Ala Xaa Val Xaa Leu Ala Asn Leu Gln 
        115                 120                 125             


Asp Phe Lys Leu Asp Val Gln His Val Ile Glu Val Asp Glu Gly Asn 
    130                 135                 140                 


Xaa Ala Val Ile Ala Cys His Leu Pro Glu Ser His Pro Lys Ala Gln 
145                 150                 155                 160 


Val Arg Tyr Ser Val Lys Gln Glu Trp Leu Glu Ala Ser Arg Gly Asn 
                165                 170                 175     


Tyr Leu Ile Met Pro Ser Gly Asn Leu Gln Ile Val Asn Ala Ser Gln 
            180                 185                 190         


Glu Asp Glu Gly Met Tyr Lys Cys Ala Ala Tyr Asn Pro Val Xaa Gln 
        195                 200                 205             


Glu Val Lys Xaa Ser Gly Ser Ser Asp Arg Leu Arg Val Arg Arg Ser 
    210                 215                 220                 


Xaa Ala Glu Ala Ala Arg Ile Ile Tyr Pro Pro Glu Ala Gln Xaa Ile 
225                 230                 235                 240 


Ile Val Xaa Lys Gly Gln Ser Leu Ile Leu Glu Cys Val Ala Ser Gly 
                245                 250                 255     


Ile Pro Pro Pro Arg Val Xaa Trp Ala Lys Asp Gly Ser Ser Val Xaa 
            260                 265                 270         


Gly Tyr Asn Lys Xaa Arg Phe Leu Leu Ser Asn Leu Leu Ile Asp Xaa 
        275                 280                 285             


Xaa Ser Glu Glu Asp Ser Gly Xaa Tyr Arg Cys Met Ala Asp Asn Gly 
    290                 295                 300                 


Val Gly Gln Pro Gly Ala Ala Val Ile Leu Tyr Asn Val Gln Val Phe 
305                 310                 315                 320 


Glu Pro Pro Glu Val Xaa Met Glu Leu Ser Gln Leu Val Ile Pro Trp 
                325                 330                 335     


Gly Gln Ser Ala Lys Leu Xaa Cys Glu Val Arg Gly Asn Pro Pro Pro 
            340                 345                 350         


Ser Val Leu Trp Leu Arg Asn Ala Val Pro Leu Ile Ser Ser Gln Arg 
        355                 360                 365             


Leu Arg Leu Ser Arg Arg Ala Leu Arg Val Leu Ser Met Gly Pro Glu 
    370                 375                 380                 


Asp Glu Gly Val Tyr Gln Cys Met Ala Glu Asn Glu Val Gly Ser Ala 
385                 390                 395                 400 


His Ala Val Val Gln Leu Arg Xaa Ser Arg Pro Ser Ile Xaa Pro Arg 
                405                 410                 415     


Leu Trp Gln Asp Ala Glu Leu Ala Xaa Gly Xaa Pro Pro Val Ser Pro 
            420                 425                 430         


Ser Lys Leu Gly Asn Pro Glu Gln Met Leu Arg Gly Gln Pro Ala Leu 
        435                 440                 445             


Pro Arg Pro Pro Xaa Ser Val Gly Pro Ala Ser Pro Gln Cys Pro Gly 
    450                 455                 460                 


Glu Lys Gly Gln Gly Ala Pro Ala Glu Ala Pro Ile Ile Leu Ser Ser 
465                 470                 475                 480 


Pro Arg Xaa Ser Lys Xaa Asp Ser Tyr Glu Leu Val Trp Arg Pro Arg 
                485                 490                 495     


His Glu Gly Ser Gly Arg Ala Pro Ile Leu Tyr Tyr Val Val Lys His 
            500                 505                 510         


Arg Lys Gln Val Xaa Asn Ser Ser Asp Asp Trp Xaa Ile Ser Gly Ile 
        515                 520                 525             


Pro Ala Asn Gln His Arg Leu Xaa Leu Xaa Arg Leu Asp Pro Gly Ser 
    530                 535                 540                 


Leu Tyr Glu Val Glu Met Ala Ala Tyr Asn Cys Ala Gly Glu Gly Gln 
545                 550                 555                 560 


Xaa Ala Met Val Xaa Phe Arg Xaa Gly Arg Arg Pro Lys Pro Glu Ile 
                565                 570                 575     


Met Ala Ser Lys Glu Gln Gln Ile Gln Arg Asp Asp Pro Gly Ala Ser 
            580                 585                 590         


Pro Gln Ser Ser Ser Gln Pro Asp His Gly Arg Leu Ser Pro Pro Glu 
        595                 600                 605             


Ala Pro Asp Arg Pro Xaa Ile Ser Xaa Ala Ser Glu Xaa Ser Val Tyr 
    610                 615                 620                 


Val Xaa Trp Ile Pro Arg Gly Asn Gly Gly Phe Pro Ile Gln Ser Phe 
625                 630                 635                 640 


Arg Val Glu Tyr Lys Lys Leu Lys Lys Val Gly Asp Trp Ile Leu Ala 
                645                 650                 655     


Xaa Ser Ala Ile Pro Pro Ser Arg Leu Ser Val Glu Ile Xaa Gly Leu 
            660                 665                 670         


Glu Lys Gly Xaa Ser Tyr Lys Phe Arg Val Arg Ala Leu Asn Met Leu 
        675                 680                 685             


Gly Glu Ser Glu Pro Ser Ala Pro Ser Arg Pro Tyr Val Val Ser Gly 
    690                 695                 700                 


Tyr Ser Gly Arg Val Tyr Glu Arg Pro Val Ala Gly Pro Tyr Ile Xaa 
705                 710                 715                 720 


Phe Xaa Asp Ala Val Asn Glu Xaa Xaa Ile Met Leu Lys Trp Met Tyr 
                725                 730                 735     


Ile Pro Ala Ser Asn Asn Asn Xaa Pro Ile His Gly Phe Tyr Ile Tyr 
            740                 745                 750         


Tyr Arg Pro Xaa Asp Ser Asp Asn Asp Ser Asp Tyr Lys Lys Asp Met 
        755                 760                 765             


Val Glu Gly Asp Lys Tyr Trp His Ser Ile Ser His Leu Gln Pro Glu 
    770                 775                 780                 


Xaa Ser Tyr Asp Ile Lys Met Gln Cys Phe Asn Glu Gly Gly Glu Ser 
785                 790                 795                 800 


Glu Phe Ser Asn Val Met Ile Cys Glu Xaa Lys Ala Arg Lys Ser Ser 
                805                 810                 815     


Gly Gln Pro Gly Arg Leu Pro Pro Pro Xaa Leu Ala Pro Pro Gln Pro 
            820                 825                 830         


Pro Leu Pro Glu Xaa Ile Glu Arg Pro Val Gly Xaa Gly Ala Met Val 
        835                 840                 845             


Ala Arg Ser Ser Asp Leu Pro Tyr Leu Ile Val Gly Val Val Leu Gly 
    850                 855                 860                 


Ser Ile Val Leu Ile Ile Val Xaa Phe Ile Pro Phe Cys Leu Trp Arg 
865                 870                 875                 880 


Ala Trp Ser Lys Gln Lys His Xaa Xaa Asp Leu Gly Phe Pro Arg Ser 
                885                 890                 895     


Ala Leu Pro Pro Ser Cys Pro Tyr Xaa Met Val Pro Leu Gly Gly Leu 
            900                 905                 910         


Pro Gly His Gln Ala Ser Gly Gln Pro Tyr Leu Ser Gly Ile Ser Gly 
        915                 920                 925             


Arg Ala Cys Ala Asn Gly Ile His Met Asn Arg Gly Cys Pro Ser Ala 
    930                 935                 940                 


Ala Val Gly Tyr Pro Gly Met Lys Pro Gln Gln His Cys Pro Gly Glu 
945                 950                 955                 960 


Leu Gln Gln Gln Ser Asp Xaa Ser Ser Leu Leu Arg Gln Xaa His Leu 
                965                 970                 975     


Gly Asn Gly Tyr Asp Pro Gln Ser His Gln Ile Xaa Arg Gly Pro Lys 
            980                 985                 990         


Ser Ser Pro Asp Glu Gly Ser Phe  Leu Tyr Xaa Leu Pro  Asp Asp Ser 
        995                 1000                 1005             


Xaa His  Gln Leu Leu Gln Pro  His His Asp Cys Cys  Gln Arg Gln 
    1010                 1015                 1020             


Glu Gln  Pro Ala Ala Val Gly  Gln Ser Gly Val Arg  Arg Ala Pro 
    1025                 1030                 1035             


Asp Ser  Pro Val Leu Glu Ala  Val Trp Asp Pro Pro  Phe His Ser 
    1040                 1045                 1050             


Gly Pro  Pro Cys Cys Leu Gly  Leu Val Pro Val Glu  Glu Val Asp 
    1055                 1060                 1065             


Ser Pro  Asp Ser Cys Gln Val  Ser Gly Gly Asp Trp  Cys Pro Gln 
    1070                 1075                 1080             


His Pro  Val Gly Ala Tyr Val  Gly Gln Glu Pro Gly  Met Gln Leu 
    1085                 1090                 1095             


Ser Pro  Gly Pro Leu Val Arg  Val Ser Phe Glu Xaa  Pro Pro Leu 
    1100                 1105                 1110             


Xaa Ile  
    1115 


<210> 4320
<211> 157
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<400> 4320
Met Leu Arg Gly Xaa Met Xaa Ala Trp Arg Gly Met Arg Pro Glu Val 
1               5                   10                  15      


Xaa Leu Ala Cys Leu Leu Leu Ala Xaa Ala Gly Cys Phe Ala Asp Leu 
            20                  25                  30          


Asn Glu Val Pro Gln Val Xaa Val Gln Pro Ala Ser Xaa Val Gln Lys 
        35                  40                  45              


Pro Gly Gly Xaa Val Ile Leu Gly Cys Val Val Glu Pro Pro Arg Met 
    50                  55                  60                  


Asn Val Xaa Trp Arg Leu Asn Gly Lys Glu Leu Asn Gly Ser Asp Asp 
65                  70                  75                  80  


Ala Leu Gly Val Leu Ile Xaa His Gly Xaa Leu Val Ile Xaa Ala Leu 
                85                  90                  95      


Asn Asn His Xaa Val Gly Arg Tyr Gln Cys Val Ala Arg Met Pro Ala 
            100                 105                 110         


Gly Ala Val Ala Ser Val Pro Ala Xaa Val Xaa Leu Ala Ser Glu Ser 
        115                 120                 125             


Ala Pro Leu Pro Pro Cys His Gly Ala Val Pro Pro His Leu Ser His 
    130                 135                 140                 


Pro Glu Ala Pro Xaa Ile His Ala Ala Ser Cys Tyr Ser 
145                 150                 155         


<210> 4321
<211> 65
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<400> 4321
Met Xaa His Glu Val Leu Ser Xaa Phe Ile Pro Ser Glu Gly Ser Ser 
1               5                   10                  15      


Ser Lys Val Glu Glu Val Asp Leu Gln Asp Phe Lys Leu Asp Val Gln 
            20                  25                  30          


His Val Ile Glu Val Asp Glu Gly Asn Xaa Ala Val Ile Ala Cys His 
        35                  40                  45              


Leu Pro Glu Ser His Pro Lys Ala Gln Val Arg Tyr Ser Val Lys Gln 
    50                  55                  60                  


Glu 
65  


<210> 4322
<211> 39
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<400> 4322
Xaa Gln Gln Gln Ser Asp Xaa Ser Ser Leu Leu Arg Gln Xaa His Leu 
1               5                   10                  15      


Gly Asn Gly Tyr Asp Pro Gln Ser His Gln Ile Xaa Arg Ala Pro Met 
            20                  25                  30          


Leu Leu Gly Pro Cys Ala Ser 
        35                  


<210> 4323
<211> 84
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(69)
<223> Selenocysteine

<400> 4323
Xaa Arg Ala Cys Ala Asn Gly Ile His Met Asn Arg Gly Cys Pro Ser 
1               5                   10                  15      


Ala Ala Val Gly Tyr Pro Gly Met Lys Pro Gln Gln His Cys Pro Gly 
            20                  25                  30          


Glu Leu Gln Gln Gln Ser Asp Xaa Ser Ser Leu Leu Arg Gln Xaa His 
        35                  40                  45              


Leu Gly Asn Gly Tyr Asp Pro Gln Ser His Gln Ile Xaa Ser Cys Cys 
    50                  55                  60                  


Ser Pro Ile Xaa Xaa Ala Ala Asn Ala Arg Ser Ser Leu Leu Leu Trp 
65                  70                  75                  80  


Ala Ser Gln Gly 
                


<210> 4324
<211> 212
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<400> 4324
Met Glu Val Leu Arg Arg Ser Ser Val Phe Ala Ala Glu Ile Met Asp 
1               5                   10                  15      


Ala Phe Asp Arg Ser Pro Xaa Asp Lys Glu Leu Val Ala Gln Ala Lys 
            20                  25                  30          


Ala Leu Gly Arg Glu Tyr Val His Ala Arg Leu Leu Arg Ala Gly Leu 
        35                  40                  45              


Ser Trp Ser Ala Pro Glu Arg Ala Ala Pro Val Pro Gly Arg Leu Ala 
    50                  55                  60                  


Glu Val Cys Ala Val Leu Leu Arg Leu Gly Asp Glu Leu Glu Met Ile 
65                  70                  75                  80  


Arg Pro Ser Val Tyr Arg Asn Val Ala Arg Gln Leu His Ile Ser Leu 
                85                  90                  95      


Gln Ser Glu Pro Val Val Xaa Asp Ala Phe Leu Ala Val Ala Gly His 
            100                 105                 110         


Ile Phe Ser Ala Gly Ile Xaa Trp Gly Lys Val Val Ser Leu Tyr Ala 
        115                 120                 125             


Val Ala Ala Gly Leu Ala Val Asp Cys Val Arg Gln Ala Gln Pro Ala 
    130                 135                 140                 


Met Val His Ala Leu Val Asp Cys Leu Gly Glu Phe Val Arg Lys Xaa 
145                 150                 155                 160 


Leu Ala Xaa Trp Leu Arg Arg Arg Gly Gly Trp Xaa Asp Val Leu Lys 
                165                 170                 175     


Cys Val Val Ser Xaa Asp Pro Gly Leu Arg Ser His Trp Leu Val Ala 
            180                 185                 190         


Ala Leu Cys Ser Phe Gly Arg Phe Leu Lys Ala Ala Phe Phe Val Leu 
        195                 200                 205             


Leu Pro Glu Arg 
    210         


<210> 4325
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 4325
Met Glu Glu Pro Glu Met Gln Leu Lys Gly Lys Lys Val Xaa Asp Lys 
1               5                   10                  15      


Phe Xaa Glu Ser Val Tyr Val Leu Ala Asn Glu Pro Ser Val Ala Leu 
            20                  25                  30          


Tyr Arg Leu Gln Glu His Val Arg Arg Ser Leu Pro Glu Leu Ala Gln 
        35                  40                  45              


His Lys Ala Asp Met Gln Arg Trp Glu Glu Gln Ser Gln Gly Ala Ile 
    50                  55                  60                  


Tyr Xaa Val Glu Tyr Ala Cys Ser Ala Val Lys Asn Leu Val Asp Ser 
65                  70                  75                  80  


Ser Val Tyr Phe Arg Ser Val Glu Gly Leu Leu Lys Gln Ala Ile Ser 
                85                  90                  95      


Ile Arg Asp His Met Asn Ala Ser Ala Gln Gly His Ser Pro Glu Glu 
            100                 105                 110         


Pro Pro Pro Pro Ser Ser Ala 
        115                 


<210> 4326
<211> 365
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<400> 4326
Met Gly Arg Lys Lys Ile Gln Ile Ser Arg Ile Leu Asp Gln Arg Asn 
1               5                   10                  15      


Arg Gln Val Xaa Phe Xaa Lys Arg Lys Phe Gly Leu Met Lys Lys Ala 
            20                  25                  30          


Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe 
        35                  40                  45              


Asn Ser Ala Asn Arg Leu Phe Gln Tyr Ala Ser Xaa Asp Met Asp Arg 
    50                  55                  60                  


Val Leu Leu Lys Tyr Xaa Glu Tyr Ser Glu Pro His Glu Ser Arg Xaa 
65                  70                  75                  80  


Asn Xaa Asp Ile Leu Glu Xaa Leu Lys Arg Arg Gly Ile Gly Leu Asp 
                85                  90                  95      


Gly Pro Glu Leu Glu Pro Asp Glu Gly Pro Glu Glu Pro Gly Glu Lys 
            100                 105                 110         


Phe Arg Arg Leu Ala Gly Glu Gly Gly Asp Pro Ala Leu Pro Arg Pro 
        115                 120                 125             


Arg Leu Tyr Pro Ala Ala Pro Ala Met Pro Ser Pro Asp Val Val Tyr 
    130                 135                 140                 


Gly Ala Leu Pro Pro Pro Gly Cys Asp Pro Ser Gly Leu Gly Glu Ala 
145                 150                 155                 160 


Leu Pro Ala Gln Ser Arg Pro Ser Pro Phe Arg Pro Ala Ala Pro Lys 
                165                 170                 175     


Ala Gly Pro Pro Gly Leu Val His Pro Leu Phe Ser Pro Ser His Leu 
            180                 185                 190         


Xaa Ser Lys Xaa Pro Pro Pro Leu Tyr Leu Pro Xaa Glu Gly Arg Arg 
        195                 200                 205             


Ser Asp Leu Pro Gly Gly Leu Ala Gly Pro Arg Gly Gly Leu Asn Xaa 
    210                 215                 220                 


Ser Arg Ser Leu Tyr Ser Gly Leu Gln Asn Pro Cys Ser Xaa Ala Xaa 
225                 230                 235                 240 


Pro Gly Pro Pro Leu Gly Ser Phe Pro Phe Leu Pro Gly Gly Pro Pro 
                245                 250                 255     


Val Gly Ala Glu Ala Trp Ala Arg Arg Val Pro Gln Pro Ala Ala Pro 
            260                 265                 270         


Pro Arg Arg Pro Pro Gln Ser Ala Ser Ser Leu Ser Ala Ser Leu Arg 
        275                 280                 285             


Pro Pro Gly Ala Pro Ala Xaa Phe Leu Arg Pro Ser Pro Ile Pro Cys 
    290                 295                 300                 


Ser Ser Pro Gly Pro Trp Gln Ser Leu Cys Gly Leu Gly Pro Pro Cys 
305                 310                 315                 320 


Ala Gly Cys Pro Trp Pro Xaa Ala Gly Pro Gly Arg Arg Ser Pro Gly 
                325                 330                 335     


Gly Xaa Ser Pro Glu Arg Ser Pro Gly Xaa Ala Arg Ala Arg Gly Asp 
            340                 345                 350         


Pro Xaa Ser Leu Gln Ala Ser Ser Glu Lys Xaa Gln Gln 
        355                 360                 365 


<210> 4327
<211> 382
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<400> 4327
Met Pro Val Pro Arg Ala Xaa Asp Lys Asp His Ser Xaa Gln Pro Gly 
1               5                   10                  15      


Xaa Met Gly Arg Lys Lys Ile Gln Ile Ser Arg Ile Leu Asp Gln Arg 
            20                  25                  30          


Asn Arg Gln Val Xaa Phe Xaa Lys Arg Lys Phe Gly Leu Met Lys Lys 
        35                  40                  45              


Ala Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile 
    50                  55                  60                  


Phe Asn Ser Ala Asn Arg Leu Phe Gln Tyr Ala Ser Xaa Asp Met Asp 
65                  70                  75                  80  


Arg Val Leu Leu Lys Tyr Xaa Glu Tyr Ser Glu Pro His Glu Ser Arg 
                85                  90                  95      


Xaa Asn Xaa Asp Ile Leu Glu Xaa Leu Lys Arg Arg Gly Ile Gly Leu 
            100                 105                 110         


Asp Gly Pro Glu Leu Glu Pro Asp Glu Gly Pro Glu Glu Pro Gly Glu 
        115                 120                 125             


Lys Phe Arg Arg Leu Ala Gly Glu Gly Gly Asp Pro Ala Leu Pro Arg 
    130                 135                 140                 


Pro Arg Leu Tyr Pro Ala Ala Pro Ala Met Pro Ser Pro Asp Val Val 
145                 150                 155                 160 


Tyr Gly Ala Leu Pro Pro Pro Gly Cys Asp Pro Ser Gly Leu Gly Glu 
                165                 170                 175     


Ala Leu Pro Ala Gln Ser Arg Pro Ser Pro Phe Arg Pro Ala Ala Pro 
            180                 185                 190         


Lys Ala Gly Pro Pro Gly Leu Val His Pro Leu Phe Ser Pro Ser His 
        195                 200                 205             


Leu Xaa Ser Lys Xaa Pro Pro Pro Leu Tyr Leu Pro Xaa Glu Gly Arg 
    210                 215                 220                 


Arg Ser Asp Leu Pro Gly Gly Leu Ala Gly Pro Arg Gly Gly Leu Asn 
225                 230                 235                 240 


Xaa Ser Arg Ser Leu Tyr Ser Gly Leu Gln Asn Pro Cys Ser Xaa Ala 
                245                 250                 255     


Xaa Pro Gly Pro Pro Leu Gly Ser Phe Pro Phe Leu Pro Gly Gly Pro 
            260                 265                 270         


Pro Val Gly Ala Glu Ala Trp Ala Arg Arg Val Pro Gln Pro Ala Ala 
        275                 280                 285             


Pro Pro Arg Arg Pro Pro Gln Ser Ala Ser Ser Leu Ser Ala Ser Leu 
    290                 295                 300                 


Arg Pro Pro Gly Ala Pro Ala Xaa Phe Leu Arg Pro Ser Pro Ile Pro 
305                 310                 315                 320 


Cys Ser Ser Pro Gly Pro Trp Gln Ser Leu Cys Gly Leu Gly Pro Pro 
                325                 330                 335     


Cys Ala Gly Cys Pro Trp Pro Xaa Ala Gly Pro Gly Arg Arg Ser Pro 
            340                 345                 350         


Gly Gly Xaa Ser Pro Glu Arg Ser Pro Gly Xaa Ala Arg Ala Arg Gly 
        355                 360                 365             


Asp Pro Xaa Ser Leu Gln Ala Ser Ser Glu Lys Xaa Gln Gln 
    370                 375                 380         


<210> 4328
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<400> 4328
Met Ala Gly Pro Trp Xaa Phe Xaa Leu Leu Cys Gly Leu Leu Ala Ala 
1               5                   10                  15      


Xaa Leu Ile Gln Ala Xaa Leu Ser Pro Xaa Ala Val Leu Ile Leu Gly 
            20                  25                  30          


Pro Lys Val Ile Lys Glu Lys Leu Xaa Gln Glu Leu Lys Asp His Asn 
        35                  40                  45              


Ala Xaa Ser Ile Leu Gln Gln Leu Pro Leu Leu Ser Ala Met Arg Glu 
    50                  55                  60                  


Lys Pro Ala Gly Gly Ile Pro Val Leu Gly Ser Leu Val Asn Xaa Val 
65                  70                  75                  80  


Leu Lys His Ile Ile Trp Leu Lys Val Ile Xaa Ala Asn Ile Leu Gln 
                85                  90                  95      


Leu Gln Val Lys Pro Ser Ala Asn Asp Gln Glu Leu Leu Val Lys Ile 
            100                 105                 110         


Pro Leu Asp Met Val Ala Gly Phe Asn Xaa Pro Leu Val Lys Xaa Ile 
        115                 120                 125             


Val Glu Phe His Met Xaa Xaa Glu Ala Gln Ala Xaa Ile Arg Met Asp 
    130                 135                 140                 


Xaa Ser Ala 
145         


<210> 4329
<211> 484
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<400> 4329
Met Ala Gly Pro Trp Xaa Phe Xaa Leu Leu Cys Gly Leu Leu Ala Ala 
1               5                   10                  15      


Xaa Leu Ile Gln Ala Xaa Leu Ser Pro Xaa Ala Val Leu Ile Leu Gly 
            20                  25                  30          


Pro Lys Val Ile Lys Glu Lys Leu Xaa Gln Glu Leu Lys Asp His Asn 
        35                  40                  45              


Ala Xaa Ser Ile Leu Gln Gln Leu Pro Leu Leu Ser Ala Met Arg Glu 
    50                  55                  60                  


Lys Pro Ala Gly Gly Ile Pro Val Leu Gly Ser Leu Val Asn Xaa Val 
65                  70                  75                  80  


Leu Lys His Ile Ile Trp Leu Lys Val Ile Xaa Ala Asn Ile Leu Gln 
                85                  90                  95      


Leu Gln Val Lys Pro Ser Ala Asn Asp Gln Glu Leu Leu Val Lys Ile 
            100                 105                 110         


Pro Leu Asp Met Val Ala Gly Phe Asn Xaa Pro Leu Val Lys Xaa Ile 
        115                 120                 125             


Val Glu Phe His Met Xaa Xaa Glu Ala Gln Ala Xaa Ile Arg Met Asp 
    130                 135                 140                 


Xaa Ser Ala Ser Gly Pro Xaa Arg Leu Val Leu Ser Asp Cys Ala Xaa 
145                 150                 155                 160 


Ser His Gly Ser Leu Arg Ile Gln Leu Leu His Lys Leu Ser Phe Leu 
                165                 170                 175     


Val Asn Ala Leu Ala Lys Gln Val Met Asn Leu Leu Val Pro Ser Leu 
            180                 185                 190         


Pro Asn Leu Val Lys Asn Gln Leu Cys Pro Val Ile Glu Ala Ser Phe 
        195                 200                 205             


Asn Gly Met Tyr Ala Asp Leu Leu Gln Leu Val Lys Val Pro Ile Ser 
    210                 215                 220                 


Leu Ser Ile Asp Arg Leu Glu Phe Asp Leu Leu Tyr Pro Ala Ile Lys 
225                 230                 235                 240 


Gly Asp Xaa Ile Gln Leu Tyr Leu Gly Ala Lys Leu Leu Asp Ser Gln 
                245                 250                 255     


Gly Lys Val Xaa Lys Trp Phe Asn Asn Ser Ala Ala Ser Leu Xaa Met 
            260                 265                 270         


Pro Xaa Leu Asp Asn Ile Pro Phe Ser Leu Ile Val Ser Gln Asp Val 
        275                 280                 285             


Val Lys Ala Ala Val Ala Ala Val Leu Ser Pro Glu Glu Phe Met Val 
    290                 295                 300                 


Leu Leu Asp Ser Val Leu Pro Glu Ser Ala His Arg Leu Lys Ser Ser 
305                 310                 315                 320 


Ile Gly Leu Ile Asn Glu Lys Ala Ala Asp Lys Leu Gly Ser Xaa Gln 
                325                 330                 335     


Ile Val Lys Ile Leu Xaa Gln Asp Xaa Pro Glu Phe Phe Ile Asp Gln 
            340                 345                 350         


Gly His Ala Lys Val Ala Gln Leu Ile Val Leu Glu Val Phe Pro Ser 
        355                 360                 365             


Ser Glu Ala Leu Arg Pro Leu Phe Xaa Leu Gly Ile Glu Ala Ser Ser 
    370                 375                 380                 


Glu Ala Gln Phe Tyr Xaa Lys Gly Asp Gln Leu Ile Leu Asn Leu Asn 
385                 390                 395                 400 


Asn Ile Ser Ser Asp Arg Ile Gln Leu Met Asn Ser Gly Ile Gly Trp 
                405                 410                 415     


Phe Gln Pro Asp Val Leu Lys Asn Ile Ile Xaa Glu Ile Ile His Ser 
            420                 425                 430         


Ile Leu Leu Pro Asn Gln Asn Gly Lys Leu Arg Ser Gly Val Pro Val 
        435                 440                 445             


Ser Leu Val Lys Ala Leu Gly Phe Glu Ala Ala Glu Ser Ser Leu Xaa 
    450                 455                 460                 


Lys Asp Ala Leu Val Leu Xaa Pro Ala Ser Leu Trp Lys Pro Ser Ser 
465                 470                 475                 480 


Pro Val Ser Gln 
                


<210> 4330
<211> 2457
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1240)..(1240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1291)..(1291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1324)..(1324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1330)..(1330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1384)..(1384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1405)..(1405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1417)..(1417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1447)..(1448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1465)..(1465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1467)..(1467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1546)..(1546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1566)..(1566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1570)..(1570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1576)..(1576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1578)..(1580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1601)..(1601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1608)..(1608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1613)..(1613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1649)..(1649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1652)..(1653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1655)..(1655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1660)..(1660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1664)..(1664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1675)..(1675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1680)..(1680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1687)..(1687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1689)..(1694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1696)..(1696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1700)..(1700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1703)..(1703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1718)..(1718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1725)..(1725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1729)..(1731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1734)..(1734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1737)..(1737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1747)..(1747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1762)..(1762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1766)..(1766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1776)..(1776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1825)..(1825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1829)..(1829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1836)..(1836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1869)..(1870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1872)..(1872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1874)..(1874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1877)..(1877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1880)..(1882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1913)..(1913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1917)..(1917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1919)..(1919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1937)..(1937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1941)..(1941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1948)..(1948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1989)..(1989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1993)..(1993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1995)..(1996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1999)..(1999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2002)..(2003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2005)..(2005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2022)..(2023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2025)..(2025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2030)..(2031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2038)..(2038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2040)..(2040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2050)..(2050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2053)..(2053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2079)..(2079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2081)..(2081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2085)..(2085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2087)..(2087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2093)..(2093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2095)..(2095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2097)..(2097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2102)..(2102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2108)..(2109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2116)..(2116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2125)..(2125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2129)..(2129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2135)..(2135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2143)..(2143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2157)..(2157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2167)..(2167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2174)..(2174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2178)..(2178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2185)..(2185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2188)..(2188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2190)..(2190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2211)..(2211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2216)..(2216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2219)..(2219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2229)..(2229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2238)..(2239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2250)..(2250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2268)..(2268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2275)..(2275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2279)..(2280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2282)..(2283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2286)..(2290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2293)..(2294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2298)..(2298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2317)..(2317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2335)..(2335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2346)..(2346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2358)..(2358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2364)..(2364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2366)..(2367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2379)..(2379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2412)..(2412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2418)..(2418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2432)..(2434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2444)..(2444)
<223> Selenocysteine

<400> 4330
Met Arg Gly Arg Arg Gly Arg Pro Pro Lys Gln Pro Ala Ala Pro Ala 
1               5                   10                  15      


Ala Glu Arg Cys Ala Pro Ala Pro Pro Pro Pro Pro Pro Pro Pro Xaa 
            20                  25                  30          


Ser Gly Pro Ile Gly Gly Leu Arg Ser Arg His Arg Gly Ser Ser Arg 
        35                  40                  45              


Gly Arg Trp Ala Ala Ala Gln Ala Glu Val Ala Pro Lys Xaa Arg Leu 
    50                  55                  60                  


Ser Ser Pro Arg Gly Gly Ser Ser Ser Arg Arg Lys Pro Pro Pro Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Pro Ser Xaa Ser Ala Pro Gly Arg Gly Gly Arg Gly 
                85                  90                  95      


Gly Gly Gly Gly Arg Xaa Gly Gly Gly Gly Gly Gly Gly His Leu Ala 
            100                 105                 110         


Arg Xaa Xaa Ala Ala Arg Arg Ala Val Asn Lys Val Val Tyr Asp Asp 
        115                 120                 125             


His Glu Ser Glu Glu Glu Glu Glu Glu Glu Asp Met Val Ser Glu Glu 
    130                 135                 140                 


Glu Glu Glu Glu Asp Gly Asp Ala Glu Glu Xaa Gln Asp Ser Glu Asp 
145                 150                 155                 160 


Asp Glu Glu Asp Glu Met Glu Glu Asp Asp Asp Asp Ser Asp Tyr Pro 
                165                 170                 175     


Glu Glu Met Glu Asp Asp Asp Asp Asp Ala Ser Tyr Cys Xaa Glu Ser 
            180                 185                 190         


Ser Phe Arg Ser His Ser Xaa Tyr Ser Ser Xaa Pro Gly Arg Arg Lys 
        195                 200                 205             


Pro Arg Val His Arg Pro Arg Ser Pro Ile Leu Glu Glu Lys Asp Ile 
    210                 215                 220                 


Pro Pro Leu Glu Phe Pro Lys Ser Ser Glu Asp Leu Met Val Pro Asn 
225                 230                 235                 240 


Glu His Ile Met Asn Val Ile Ala Ile Tyr Glu Val Leu Arg Asn Phe 
                245                 250                 255     


Gly Xaa Val Leu Arg Leu Ser Pro Phe Arg Phe Glu Asp Phe Cys Ala 
            260                 265                 270         


Ala Leu Val Ser Gln Glu Gln Cys Xaa Leu Met Ala Glu Met His Val 
        275                 280                 285             


Val Leu Leu Lys Ala Val Leu Arg Glu Glu Asp Xaa Ser Asn Xaa Xaa 
    290                 295                 300                 


Phe Gly Pro Ala Asp Leu Lys Asp Ser Val Asn Ser Xaa Leu Tyr Phe 
305                 310                 315                 320 


Ile Asp Gly Met Xaa Trp Pro Glu Val Leu Arg Val Tyr Cys Glu Ser 
                325                 330                 335     


Asp Lys Glu Tyr His His Val Leu Pro Tyr Gln Glu Ala Glu Asp Tyr 
            340                 345                 350         


Pro Tyr Gly Pro Val Glu Asn Lys Ile Lys Val Leu Gln Phe Leu Val 
        355                 360                 365             


Asp Gln Phe Leu Xaa Xaa Asn Ile Ala Arg Glu Glu Leu Met Ser Glu 
    370                 375                 380                 


Gly Val Ile Gln Tyr Asp Asp His Cys Arg Val Cys His Lys Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Cys Cys Glu Xaa Cys Ser Ala Val Tyr His Leu Glu Cys 
                405                 410                 415     


Val Lys Pro Pro Leu Glu Glu Val Pro Glu Asp Glu Trp Gln Cys Glu 
            420                 425                 430         


Val Cys Val Ala His Lys Val Pro Gly Val Xaa Asp Cys Val Ala Glu 
        435                 440                 445             


Ile Gln Lys Asn Lys Pro Tyr Ile Arg His Glu Pro Ile Gly Tyr Asp 
    450                 455                 460                 


Arg Ser Arg Arg Lys Tyr Trp Phe Leu Asn Arg Arg Leu Ile Ile Glu 
465                 470                 475                 480 


Glu Asp Xaa Glu Asn Glu Asn Glu Lys Lys Ile Trp Tyr Tyr Ser Xaa 
                485                 490                 495     


Lys Val Gln Leu Ala Glu Leu Ile Asp Cys Leu Asp Lys Asp Tyr Trp 
            500                 505                 510         


Glu Ala Glu Leu Cys Lys Ile Leu Glu Glu Met Arg Glu Glu Ile His 
        515                 520                 525             


Arg His Met Asp Ile Xaa Glu Asp Leu Xaa Asn Lys Ala Arg Gly Ser 
    530                 535                 540                 


Asn Lys Ser Phe Leu Ala Ala Ala Asn Glu Glu Ile Leu Glu Ser Ile 
545                 550                 555                 560 


Arg Ala Lys Lys Gly Asp Ile Asp Asn Val Lys Ser Pro Glu Glu Xaa 
                565                 570                 575     


Glu Lys Asp Lys Asn Glu Xaa Glu Asn Asp Ser Lys Asp Ala Glu Lys 
            580                 585                 590         


Asn Arg Glu Glu Phe Glu Asp Gln Ser Leu Glu Lys Asp Ser Asp Asp 
        595                 600                 605             


Lys Xaa Pro Asp Asp Asp Pro Glu Gln Gly Lys Ser Glu Glu Pro Xaa 
    610                 615                 620                 


Glu Val Gly Asp Lys Gly Asn Ser Val Ser Ala Asn Leu Gly Asp Asn 
625                 630                 635                 640 


Xaa Xaa Asn Ala Xaa Ser Glu Glu Xaa Ser Pro Ser Glu Gly Arg Ser 
                645                 650                 655     


Pro Val Gly Cys Leu Ser Glu Xaa Pro Asp Ser Ser Asn Met Ala Glu 
            660                 665                 670         


Lys Lys Val Ala Ser Glu Leu Pro Gln Asp Val Pro Val Gly Asp Phe 
        675                 680                 685             


Lys Ser Glu Lys Ser Asn Gly Glu Leu Ser Glu Ser Pro Gly Ala Gly 
    690                 695                 700                 


Lys Gly Ala Ser Gly Ser Xaa Arg Ile Ile Xaa Arg Leu Arg Asn Pro 
705                 710                 715                 720 


Asp Ser Lys Leu Ser Gln Leu Lys Ser Gln Gln Val Ala Ala Ala Ala 
                725                 730                 735     


His Glu Ala Asn Lys Leu Phe Lys Glu Gly Lys Glu Val Leu Val Val 
            740                 745                 750         


Asn Ser Gln Gly Glu Ile Ser Arg Leu Ser Xaa Lys Lys Glu Val Ile 
        755                 760                 765             


Met Lys Gly Asn Ile Asn Asn Tyr Phe Lys Leu Gly Gln Glu Gly Lys 
    770                 775                 780                 


Tyr Arg Val Tyr His Asn Gln Tyr Ser Xaa Asn Ser Phe Ala Leu Asn 
785                 790                 795                 800 


Lys His Gln His Arg Glu Asp His Asp Lys Arg Arg His Leu Ala His 
                805                 810                 815     


Lys Phe Cys Leu Xaa Pro Ala Gly Glu Phe Lys Trp Asn Gly Ser Val 
            820                 825                 830         


His Gly Ser Lys Val Leu Xaa Ile Ser Xaa Leu Arg Leu Xaa Ile Xaa 
        835                 840                 845             


Gln Leu Glu Asn Asn Ile Pro Ser Ser Phe Leu His Pro Asn Trp Ala 
    850                 855                 860                 


Ser His Arg Ala Asn Trp Ile Lys Ala Val Gln Met Cys Ser Lys Pro 
865                 870                 875                 880 


Arg Glu Phe Ala Leu Ala Leu Ala Ile Leu Glu Cys Ala Val Lys Pro 
                885                 890                 895     


Val Val Met Leu Pro Ile Trp Arg Glu Ser Leu Gly His Xaa Arg Leu 
            900                 905                 910         


His Arg Met Xaa Ser Ile Glu Arg Glu Glu Lys Glu Lys Val Lys Lys 
        915                 920                 925             


Lys Glu Lys Lys Gln Glu Glu Glu Glu Xaa Met Gln Gln Ala Xaa Trp 
    930                 935                 940                 


Val Lys Tyr Xaa Phe Pro Val Lys His Gln Val Trp Lys Gln Lys Gly 
945                 950                 955                 960 


Glu Glu Tyr Arg Val Xaa Gly Tyr Gly Gly Trp Ser Trp Ile Ser Lys 
                965                 970                 975     


Xaa His Val Tyr Arg Phe Val Pro Lys Leu Pro Gly Asn Xaa Asn Val 
            980                 985                 990         


Asn Tyr Arg Lys Ser Leu Glu Gly  Xaa Lys Asn Asn Met  Asp Glu Asn 
        995                 1000                 1005             


Met Asp  Glu Ser Asp Lys Arg  Lys Cys Ser Arg Ser  Pro Lys Lys 
    1010                 1015                 1020             


Ile Lys  Ile Glu Pro Asp Ser  Glu Lys Asp Glu Val  Lys Gly Ser 
    1025                 1030                 1035             


Asp Ala  Ala Lys Gly Ala Asp  Gln Asn Glu Met Asp  Ile Ser Lys 
    1040                 1045                 1050             


Ile Xaa  Glu Lys Lys Asp Gln  Asp Val Lys Glu Leu  Leu Asp Ser 
    1055                 1060                 1065             


Asp Ser  Asp Lys Pro Cys Lys  Glu Glu Pro Met Glu  Val Asp Asp 
    1070                 1075                 1080             


Asp Met  Lys Xaa Glu Ser His  Val Asn Cys Gln Glu  Ser Ser Gln 
    1085                 1090                 1095             


Val Asp  Val Val Asn Val Ser  Glu Gly Phe His Leu  Arg Xaa Ser 
    1100                 1105                 1110             


Tyr Lys  Lys Lys Xaa Lys Ser  Ser Lys Leu Asp Gly  Leu Leu Glu 
    1115                 1120                 1125             


Arg Arg  Ile Lys Gln Phe Xaa  Leu Glu Glu Lys Gln  Arg Leu Glu 
    1130                 1135                 1140             


Lys Ile  Lys Leu Glu Gly Gly  Ile Lys Gly Ile Gly  Lys Xaa Ser 
    1145                 1150                 1155             


Xaa Asn  Ser Ser Lys Asn Leu  Ser Glu Ser Pro Val  Ile Xaa Lys 
    1160                 1165                 1170             


Ala Lys  Glu Gly Cys Gln Ser  Asp Ser Met Arg Gln  Glu Gln Ser 
    1175                 1180                 1185             


Pro Asn  Ala Asn Asn Asp Gln  Pro Glu Asp Leu Ile  Gln Gly Cys 
    1190                 1195                 1200             


Ser Glu  Ser Asp Ser Ser Val  Leu Arg Met Ser Asp  Pro Ser His 
    1205                 1210                 1215             


Xaa Xaa  Asn Lys Leu Tyr Pro  Lys Asp Arg Val Leu  Asp Asp Val 
    1220                 1225                 1230             


Ser Ile  Arg Ser Pro Glu Xaa  Lys Cys Pro Lys Gln  Asn Ser Ile 
    1235                 1240                 1245             


Glu Asn  Asp Ile Glu Glu Lys  Val Ser Asp Leu Ala  Ser Arg Gly 
    1250                 1255                 1260             


Gln Glu  Pro Ser Lys Ser Lys  Xaa Lys Gly Asn Asp  Phe Phe Ile 
    1265                 1270                 1275             


Asp Asp  Ser Lys Leu Ala Ser  Ala Asp Asp Ile Gly  Xaa Leu Ile 
    1280                 1285                 1290             


Cys Lys  Asn Lys Lys Pro Leu  Ile Gln Glu Glu Ser  Asp Xaa Ile 
    1295                 1300                 1305             


Val Ser  Ser Ser Lys Ser Ala  Leu His Ser Ser Val  Pro Lys Ser 
    1310                 1315                 1320             


Xaa Asn  Asp Arg Asp Ala Xaa  Pro Leu Ser Arg Ala  Met Asp Phe 
    1325                 1330                 1335             


Glu Gly  Lys Leu Gly Cys Asp  Ser Glu Ser Asn Ser  Xaa Leu Glu 
    1340                 1345                 1350             


Asn Ser  Ser Asp Xaa Val Ser  Ile Gln Asp Ser Ser  Glu Glu Asp 
    1355                 1360                 1365             


Met Ile  Val Gln Asn Ser Asn  Glu Ser Ile Ser Glu  Gln Phe Arg 
    1370                 1375                 1380             


Xaa Arg  Glu Gln Asp Val Glu  Val Leu Glu Pro Leu  Lys Cys Glu 
    1385                 1390                 1395             


Leu Val  Ser Gly Glu Ser Xaa  Gly Asn Cys Glu Asp  Arg Leu Pro 
    1400                 1405                 1410             


Val Lys  Gly Xaa Glu Ala Asn  Gly Lys Lys Pro Ser  Gln Gln Lys 
    1415                 1420                 1425             


Lys Leu  Glu Glu Arg Pro Val  Asn Lys Cys Ser Asp  Gln Ile Lys 
    1430                 1435                 1440             


Leu Lys  Asn Xaa Xaa Asp Lys  Lys Asn Asn Glu Asn  Arg Glu Ser 
    1445                 1450                 1455             


Glu Lys  Lys Gly Gln Arg Xaa  Ser Xaa Phe Gln Ile  Asn Gly Lys 
    1460                 1465                 1470             


Asp Asn  Lys Pro Lys Ile Tyr  Leu Lys Gly Glu Cys  Leu Lys Glu 
    1475                 1480                 1485             


Ile Ser  Glu Ser Arg Val Val  Ser Gly Asn Val Glu  Pro Lys Val 
    1490                 1495                 1500             


Asn Asn  Ile Asn Lys Ile Ile  Pro Glu Asn Asp Ile  Lys Ser Leu 
    1505                 1510                 1515             


Xaa Val  Lys Glu Ser Ala Ile  Arg Pro Phe Ile Asn  Gly Asp Val 
    1520                 1525                 1530             


Ile Met  Glu Asp Phe Asn Glu  Arg Asn Ser Ser Glu  Xaa Lys Ser 
    1535                 1540                 1545             


His Leu  Leu Ser Ser Ser Asp  Ala Glu Gly Asn Tyr  Arg Asp Ser 
    1550                 1555                 1560             


Leu Glu  Xaa Leu Pro Ser Xaa  Lys Glu Ser Asp Ser  Xaa Gln Xaa 
    1565                 1570                 1575             


Xaa Xaa  Pro Ser Ala Ser Cys  Pro Glu Ser Asn Ser  Val Asn Gln 
    1580                 1585                 1590             


Val Glu  Asp Met Glu Ile Glu  Xaa Ser Glu Val Lys  Lys Val Xaa 
    1595                 1600                 1605             


Ser Ser  Pro Ile Xaa Ser Glu  Glu Glu Ser Asn Leu  Ser Asn Asp 
    1610                 1615                 1620             


Phe Ile  Asp Glu Asn Gly Leu  Pro Ile Asn Lys Asn  Glu Asn Val 
    1625                 1630                 1635             


Asn Gly  Glu Ser Lys Arg Lys  Xaa Val Ile Xaa Glu  Val Xaa Xaa 
    1640                 1645                 1650             


Met Xaa  Ser Xaa Val Ala Xaa  Glu Ser Lys Xaa Val  Ile Lys Val 
    1655                 1660                 1665             


Glu Lys  Gly Asp Lys Gln Xaa  Val Val Ser Ser Xaa  Glu Asn Cys 
    1670                 1675                 1680             


Ala Lys  Ser Xaa Val Xaa Xaa  Xaa Xaa Xaa Xaa Val  Xaa Lys Leu 
    1685                 1690                 1695             


Ser Xaa  Pro Ser Xaa Gly Gly  Ser Val Asp Ile Ile  Ser Val Lys 
    1700                 1705                 1710             


Glu Gln  Ser Lys Xaa Val Val  Xaa Xaa Xaa Val Xaa  Asp Ser Leu 
    1715                 1720                 1725             


Xaa Xaa  Xaa Gly Gly Xaa Leu  Val Xaa Ser Met Xaa  Val Ser Lys 
    1730                 1735                 1740             


Glu Tyr  Ser Xaa Arg Asp Lys  Val Lys Leu Met Lys  Phe Ser Arg 
    1745                 1750                 1755             


Pro Lys  Lys Xaa Arg Ser Gly  Xaa Ala Leu Pro Ser  Tyr Arg Lys 
    1760                 1765                 1770             


Phe Val  Xaa Lys Ser Ser Lys  Lys Ser Ile Phe Val  Leu Pro Asn 
    1775                 1780                 1785             


Asp Asp  Leu Lys Lys Leu Ala  Arg Lys Gly Gly Ile  Arg Glu Val 
    1790                 1795                 1800             


Pro Tyr  Phe Asn Tyr Asn Ala  Lys Pro Ala Leu Asp  Ile Trp Pro 
    1805                 1810                 1815             


Tyr Pro  Ser Pro Arg Pro Xaa  Phe Gly Ile Xaa Trp  Arg Tyr Arg 
    1820                 1825                 1830             


Leu Gln  Xaa Val Lys Ser Leu  Ala Gly Val Ser Leu  Met Leu Arg 
    1835                 1840                 1845             


Leu Leu  Trp Ala Ser Leu Arg  Trp Asp Asp Met Ala  Ala Lys Ala 
    1850                 1855                 1860             


Pro Pro  Gly Gly Gly Xaa Xaa  Arg Xaa Glu Xaa Ser  Glu Xaa Glu 
    1865                 1870                 1875             


Ile Xaa  Xaa Xaa Glu Ile Ile  Lys Arg Arg Asp Val  Gly Pro Tyr 
    1880                 1885                 1890             


Gly Ile  Arg Ser Glu Tyr Cys  Ile Arg Lys Ile Ile  Cys Pro Ile 
    1895                 1900                 1905             


Gly Val  Pro Glu Xaa Pro Lys  Glu Xaa Pro Xaa Pro  Gln Arg Lys 
    1910                 1915                 1920             


Gly Leu  Arg Ser Ser Ala Leu  Arg Pro Lys Arg Pro  Glu Xaa Pro 
    1925                 1930                 1935             


Lys Gln  Xaa Gly Pro Val Ile  Ile Glu Xaa Trp Val  Ala Glu Glu 
    1940                 1945                 1950             


Glu Leu  Glu Leu Trp Glu Ile  Arg Ala Phe Ala Glu  Arg Val Glu 
    1955                 1960                 1965             


Lys Glu  Lys Ala Gln Ala Val  Glu Gln Gln Ala Lys  Lys Arg Leu 
    1970                 1975                 1980             


Glu Gln  Gln Lys Pro Xaa Val  Ile Ala Xaa Ser Xaa  Xaa Ser Pro 
    1985                 1990                 1995             


Xaa Ser  Ser Xaa Xaa Ser Xaa  Ile Ser Pro Ala Gln  Lys Val Met 
    2000                 2005                 2010             


Val Ala  Pro Ile Ser Gly Ser  Val Xaa Xaa Gly Xaa  Lys Met Val 
    2015                 2020                 2025             


Leu Xaa  Xaa Lys Val Gly Ser  Pro Ala Xaa Val Xaa  Phe Gln Gln 
    2030                 2035                 2040             


Asn Lys  Asn Phe His Gln Xaa  Phe Ala Xaa Trp Val  Lys Gln Gly 
    2045                 2050                 2055             


Gln Ser  Asn Ser Gly Val Val  Gln Val Gln Gln Lys  Val Leu Gly 
    2060                 2065                 2070             


Ile Ile  Pro Ser Ser Xaa Gly  Xaa Ser Gln Gln Xaa  Phe Xaa Ser 
    2075                 2080                 2085             


Phe Gln  Pro Arg Xaa Ala Xaa  Val Xaa Ile Arg Pro  Asn Xaa Ser 
    2090                 2095                 2100             


Gly Ser  Gly Gly Xaa Xaa Ser  Asn Ser Gln Val Ile  Xaa Gly Pro 
    2105                 2110                 2115             


Gln Ile  Arg Pro Gly Met Xaa  Val Ile Arg Xaa Pro  Leu Gln Gln 
    2120                 2125                 2130             


Ser Xaa  Leu Gly Lys Ala Ile  Ile Arg Xaa Pro Val  Met Val Gln 
    2135                 2140                 2145             


Pro Gly  Ala Pro Gln Gln Val  Met Xaa Gln Ile Ile  Arg Gly Gln 
    2150                 2155                 2160             


Pro Val  Ser Xaa Ala Val Ser  Ala Pro Asn Xaa Val  Ser Ser Xaa 
    2165                 2170                 2175             


Pro Gly  Gln Lys Ser Leu Xaa  Ser Ala Xaa Ser Xaa  Ser Asn Ile 
    2180                 2185                 2190             


Gln Ser  Ser Ala Ser Gln Pro  Pro Arg Pro Gln Gln  Gly Gln Val 
    2195                 2200                 2205             


Lys Leu  Xaa Met Ala Gln Leu  Xaa Gln Leu Xaa Gln  Gly His Gly 
    2210                 2215                 2220             


Gly Asn  Gln Gly Leu Xaa Val  Val Ile Gln Gly Gln  Gly Gln Xaa 
    2225                 2230                 2235             


Xaa Gly  Gln Leu Gln Leu Ile  Pro Gln Gly Val Xaa  Val Leu Pro 
    2240                 2245                 2250             


Gly Pro  Gly Gln Gln Leu Met  Gln Ala Ala Met Pro  Asn Gly Xaa 
    2255                 2260                 2265             


Val Gln  Arg Phe Leu Phe Xaa  Pro Leu Ala Xaa Xaa  Ala Xaa Xaa 
    2270                 2275                 2280             


Ala Ser  Xaa Xaa Xaa Xaa Xaa  Val Ser Xaa Xaa Ala  Ala Gly Xaa 
    2285                 2290                 2295             


Gly Glu  Gln Arg Gln Ser Lys  Leu Ser Pro Gln Met  Gln Val His 
    2300                 2305                 2310             


Gln Asp  Lys Xaa Leu Pro Pro  Ala Gln Ser Ser Ser  Val Gly Pro 
    2315                 2320                 2325             


Ala Glu  Ala Gln Pro Gln Xaa  Ala Gln Pro Ser Ala  Gln Pro Gln 
    2330                 2335                 2340             


Pro Gln  Xaa Gln Pro Gln Ser  Pro Ala Gln Pro Glu  Val Gln Xaa 
    2345                 2350                 2355             


Gln Pro  Glu Val Gln Xaa Gln  Xaa Xaa Val Ser Ser  His Val Pro 
    2360                 2365                 2370             


Ser Glu  Ala Gln Pro Xaa His  Ala Gln Ser Ser Lys  Pro Gln Val 
    2375                 2380                 2385             


Ala Ala  Gln Ser Gln Pro Gln  Ser Asn Val Gln Gly  Gln Ser Pro 
    2390                 2395                 2400             


Val Arg  Val Gln Ser Pro Ser  Gln Xaa Arg Ile Arg  Pro Ser Xaa 
    2405                 2410                 2415             


Pro Ser  Gln Leu Ser Pro Gly  Gln Gln Ser Gln Val  Gln Xaa Xaa 
    2420                 2425                 2430             


Xaa Ser  Gln Pro Ile Pro Ile  Gln Pro His Xaa Ser  Leu Gln Ile 
    2435                 2440                 2445             


Pro Ser  Gln Gly Gln Pro Gln  Ser Gln 
    2450                 2455         


<210> 4331
<211> 2920
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1208)..(1208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1244)..(1244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1267)..(1267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1321)..(1321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1342)..(1342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1354)..(1354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1384)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1402)..(1402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1456)..(1456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1503)..(1503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1507)..(1507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1515)..(1517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1538)..(1538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1550)..(1550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1583)..(1583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1589)..(1590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1592)..(1592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1597)..(1597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1601)..(1601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1612)..(1612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1617)..(1617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1624)..(1624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1626)..(1631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1637)..(1637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1655)..(1655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1658)..(1660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1662)..(1662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1666)..(1668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1671)..(1671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1674)..(1674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1677)..(1677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1684)..(1684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1699)..(1699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1703)..(1703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1713)..(1713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1762)..(1762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1766)..(1766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1806)..(1807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1809)..(1809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1811)..(1811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1814)..(1814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1817)..(1819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1850)..(1850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1854)..(1854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1856)..(1856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1874)..(1874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1878)..(1878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1885)..(1885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1926)..(1926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1930)..(1930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1932)..(1933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1936)..(1936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1939)..(1940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1942)..(1942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1959)..(1960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1962)..(1962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1967)..(1968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1975)..(1975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1977)..(1977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1987)..(1987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1990)..(1990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2016)..(2016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2018)..(2018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2022)..(2022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2024)..(2024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2030)..(2030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2032)..(2032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2034)..(2034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2039)..(2039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2045)..(2046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2053)..(2053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2062)..(2062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2066)..(2066)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2072)..(2072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2080)..(2080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2094)..(2094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2104)..(2104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2111)..(2111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2115)..(2115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2122)..(2122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2125)..(2125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2127)..(2127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2148)..(2148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2153)..(2153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2156)..(2156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2166)..(2166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2175)..(2176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2187)..(2187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2205)..(2205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2212)..(2212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2216)..(2217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2219)..(2220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2223)..(2227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2230)..(2231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2235)..(2235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2254)..(2254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2272)..(2272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2283)..(2283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2295)..(2295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2301)..(2301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2303)..(2304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2316)..(2316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2349)..(2349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2355)..(2355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2369)..(2371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2381)..(2381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2401)..(2401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2403)..(2403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2409)..(2409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2414)..(2414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2483)..(2483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2491)..(2491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2526)..(2526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2558)..(2558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2609)..(2609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2664)..(2664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2674)..(2674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2696)..(2696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2701)..(2701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2703)..(2703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2731)..(2732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2736)..(2736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2740)..(2740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2748)..(2748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2792)..(2792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2797)..(2797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2800)..(2800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2803)..(2803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2850)..(2850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2864)..(2864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2871)..(2871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2918)..(2918)
<223> Selenocysteine

<400> 4331
Met Arg Gly Arg Arg Gly Arg Pro Pro Lys Gln Pro Ala Ala Pro Ala 
1               5                   10                  15      


Ala Glu Arg Cys Ala Pro Ala Pro Pro Pro Pro Pro Pro Pro Pro Xaa 
            20                  25                  30          


Ser Gly Pro Ile Gly Gly Leu Arg Ser Arg His Arg Gly Ser Ser Arg 
        35                  40                  45              


Gly Arg Trp Ala Ala Ala Gln Ala Glu Val Ala Pro Lys Xaa Arg Leu 
    50                  55                  60                  


Ser Ser Pro Arg Gly Gly Ser Ser Ser Arg Arg Lys Pro Pro Pro Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Pro Ser Xaa Ser Ala Pro Gly Arg Gly Gly Arg Gly 
                85                  90                  95      


Gly Gly Gly Gly Arg Xaa Gly Gly Gly Gly Gly Gly Gly His Leu Ala 
            100                 105                 110         


Arg Xaa Xaa Ala Ala Arg Arg Ala Val Asn Lys Val Val Tyr Asp Asp 
        115                 120                 125             


His Glu Ser Glu Glu Glu Glu Glu Glu Glu Asp Met Val Ser Glu Glu 
    130                 135                 140                 


Glu Glu Glu Glu Asp Gly Asp Ala Glu Glu Xaa Gln Asp Ser Glu Asp 
145                 150                 155                 160 


Asp Glu Glu Asp Glu Met Glu Glu Asp Asp Asp Asp Ser Asp Tyr Pro 
                165                 170                 175     


Glu Glu Met Glu Asp Asp Asp Asp Asp Ala Ser Tyr Cys Xaa Glu Ser 
            180                 185                 190         


Ser Phe Arg Ser His Ser Xaa Tyr Ser Ser Xaa Pro Gly Arg Arg Lys 
        195                 200                 205             


Pro Arg Val His Arg Pro Arg Ser Pro Ile Leu Glu Glu Lys Asp Ile 
    210                 215                 220                 


Pro Pro Leu Glu Phe Pro Lys Ser Ser Glu Asp Leu Met Val Pro Asn 
225                 230                 235                 240 


Glu His Ile Met Asn Val Ile Ala Ile Tyr Glu Val Leu Arg Asn Phe 
                245                 250                 255     


Gly Xaa Val Leu Arg Leu Ser Pro Phe Arg Phe Glu Asp Phe Cys Ala 
            260                 265                 270         


Ala Leu Val Ser Gln Glu Gln Cys Xaa Leu Met Ala Glu Met His Val 
        275                 280                 285             


Val Leu Leu Lys Ala Val Leu Arg Glu Glu Asp Xaa Ser Asn Xaa Xaa 
    290                 295                 300                 


Phe Gly Pro Ala Asp Leu Lys Asp Ser Val Asn Ser Xaa Leu Tyr Phe 
305                 310                 315                 320 


Ile Asp Gly Met Xaa Trp Pro Glu Val Leu Arg Val Tyr Cys Glu Ser 
                325                 330                 335     


Asp Lys Glu Tyr His His Val Leu Pro Tyr Gln Glu Ala Glu Asp Tyr 
            340                 345                 350         


Pro Tyr Gly Pro Val Glu Asn Lys Ile Lys Val Leu Gln Phe Leu Val 
        355                 360                 365             


Asp Gln Phe Leu Xaa Xaa Asn Ile Ala Arg Glu Glu Leu Met Ser Glu 
    370                 375                 380                 


Gly Val Ile Gln Tyr Asp Asp His Cys Arg Val Cys His Lys Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Cys Cys Glu Xaa Cys Ser Ala Val Tyr His Leu Glu Cys 
                405                 410                 415     


Val Lys Pro Pro Leu Glu Glu Val Pro Glu Asp Glu Trp Gln Cys Glu 
            420                 425                 430         


Val Cys Val Ala His Lys Val Pro Gly Val Xaa Asp Cys Val Ala Glu 
        435                 440                 445             


Ile Gln Lys Asn Lys Pro Tyr Ile Arg His Glu Pro Ile Gly Tyr Asp 
    450                 455                 460                 


Arg Ser Arg Arg Lys Tyr Trp Phe Leu Asn Arg Arg Leu Ile Ile Glu 
465                 470                 475                 480 


Glu Asp Xaa Glu Asn Glu Asn Glu Lys Lys Ile Trp Tyr Tyr Ser Xaa 
                485                 490                 495     


Lys Val Gln Leu Ala Glu Leu Ile Asp Cys Leu Asp Lys Asp Tyr Trp 
            500                 505                 510         


Glu Ala Glu Leu Cys Lys Ile Leu Glu Glu Met Arg Glu Glu Ile His 
        515                 520                 525             


Arg His Met Asp Ile Xaa Glu Asp Leu Xaa Asn Lys Ala Arg Gly Ser 
    530                 535                 540                 


Asn Lys Ser Phe Leu Ala Ala Ala Asn Glu Glu Ile Leu Glu Ser Ile 
545                 550                 555                 560 


Arg Ala Lys Lys Gly Asp Ile Asp Asn Val Lys Ser Pro Glu Glu Xaa 
                565                 570                 575     


Glu Lys Asp Lys Asn Glu Xaa Glu Asn Asp Ser Lys Asp Ala Glu Lys 
            580                 585                 590         


Asn Arg Glu Glu Phe Glu Asp Gln Ser Leu Glu Lys Asp Ser Asp Asp 
        595                 600                 605             


Lys Xaa Pro Asp Asp Asp Pro Glu Gln Gly Lys Ser Glu Val Gly Asp 
    610                 615                 620                 


Phe Lys Ser Glu Lys Ser Asn Gly Glu Leu Ser Glu Ser Pro Gly Ala 
625                 630                 635                 640 


Gly Lys Gly Ala Ser Gly Ser Xaa Arg Ile Ile Xaa Arg Leu Arg Asn 
                645                 650                 655     


Pro Asp Ser Lys Leu Ser Gln Leu Lys Ser Gln Gln Val Ala Ala Ala 
            660                 665                 670         


Ala His Glu Ala Asn Lys Leu Phe Lys Glu Gly Lys Glu Val Leu Val 
        675                 680                 685             


Val Asn Ser Gln Gly Glu Ile Ser Arg Leu Ser Xaa Lys Lys Glu Val 
    690                 695                 700                 


Ile Met Lys Gly Asn Ile Asn Asn Tyr Phe Lys Leu Gly Gln Glu Gly 
705                 710                 715                 720 


Lys Tyr Arg Val Tyr His Asn Gln Tyr Ser Xaa Asn Ser Phe Ala Leu 
                725                 730                 735     


Asn Lys His Gln His Arg Glu Asp His Asp Lys Arg Arg His Leu Ala 
            740                 745                 750         


His Lys Phe Cys Leu Xaa Pro Ala Gly Glu Phe Lys Trp Asn Gly Ser 
        755                 760                 765             


Val His Gly Ser Lys Val Leu Xaa Ile Ser Xaa Leu Arg Leu Xaa Ile 
    770                 775                 780                 


Xaa Gln Leu Glu Asn Asn Ile Pro Ser Ser Phe Leu His Pro Asn Trp 
785                 790                 795                 800 


Ala Ser His Arg Ala Asn Trp Ile Lys Ala Val Gln Met Cys Ser Lys 
                805                 810                 815     


Pro Arg Glu Phe Ala Leu Ala Leu Ala Ile Leu Glu Cys Ala Val Lys 
            820                 825                 830         


Pro Val Val Met Leu Pro Ile Trp Arg Glu Ser Leu Gly His Xaa Arg 
        835                 840                 845             


Leu His Arg Met Xaa Ser Ile Glu Arg Glu Glu Lys Glu Lys Val Lys 
    850                 855                 860                 


Lys Lys Glu Lys Lys Gln Glu Glu Glu Glu Xaa Met Gln Gln Ala Xaa 
865                 870                 875                 880 


Trp Val Lys Tyr Xaa Phe Pro Val Lys His Gln Val Trp Lys Gln Lys 
                885                 890                 895     


Gly Glu Glu Tyr Arg Val Xaa Gly Tyr Gly Gly Trp Ser Trp Ile Ser 
            900                 905                 910         


Lys Xaa His Val Tyr Arg Phe Val Pro Lys Leu Pro Gly Asn Xaa Asn 
        915                 920                 925             


Val Asn Tyr Arg Lys Ser Leu Glu Gly Xaa Lys Asn Asn Met Asp Glu 
    930                 935                 940                 


Asn Met Asp Glu Ser Asp Lys Arg Lys Cys Ser Arg Ser Pro Lys Lys 
945                 950                 955                 960 


Ile Lys Ile Glu Pro Asp Ser Glu Lys Asp Glu Val Lys Gly Ser Asp 
                965                 970                 975     


Ala Ala Lys Gly Ala Asp Gln Asn Glu Met Asp Ile Ser Lys Ile Xaa 
            980                 985                 990         


Glu Lys Lys Asp Gln Asp Val Lys  Glu Leu Leu Asp Ser  Asp Ser Asp 
        995                 1000                 1005             


Lys Pro  Cys Lys Glu Glu Pro  Met Glu Val Asp Asp  Asp Met Lys 
    1010                 1015                 1020             


Xaa Glu  Ser His Val Asn Cys  Gln Glu Ser Ser Gln  Val Asp Val 
    1025                 1030                 1035             


Val Asn  Val Ser Glu Gly Phe  His Leu Arg Xaa Ser  Tyr Lys Lys 
    1040                 1045                 1050             


Lys Xaa  Lys Ser Ser Lys Leu  Asp Gly Leu Leu Glu  Arg Arg Ile 
    1055                 1060                 1065             


Lys Gln  Phe Xaa Leu Glu Glu  Lys Gln Arg Leu Glu  Lys Ile Lys 
    1070                 1075                 1080             


Leu Glu  Gly Gly Ile Lys Gly  Ile Gly Lys Xaa Ser  Xaa Asn Ser 
    1085                 1090                 1095             


Ser Lys  Asn Leu Ser Glu Ser  Pro Val Ile Xaa Lys  Ala Lys Glu 
    1100                 1105                 1110             


Gly Cys  Gln Ser Asp Ser Met  Arg Gln Glu Gln Ser  Pro Asn Ala 
    1115                 1120                 1125             


Asn Asn  Asp Gln Pro Glu Asp  Leu Ile Gln Gly Cys  Ser Glu Ser 
    1130                 1135                 1140             


Asp Ser  Ser Val Leu Arg Met  Ser Asp Pro Ser His  Xaa Xaa Asn 
    1145                 1150                 1155             


Lys Leu  Tyr Pro Lys Asp Arg  Val Leu Asp Asp Val  Ser Ile Arg 
    1160                 1165                 1170             


Ser Pro  Glu Xaa Lys Cys Pro  Lys Gln Asn Ser Ile  Glu Asn Asp 
    1175                 1180                 1185             


Ile Glu  Glu Lys Val Ser Asp  Leu Ala Ser Arg Gly  Gln Glu Pro 
    1190                 1195                 1200             


Ser Lys  Ser Lys Xaa Lys Gly  Asn Asp Phe Phe Ile  Asp Asp Ser 
    1205                 1210                 1215             


Lys Leu  Ala Ser Ala Asp Asp  Ile Gly Xaa Leu Ile  Cys Lys Asn 
    1220                 1225                 1230             


Lys Lys  Pro Leu Ile Gln Glu  Glu Ser Asp Xaa Ile  Val Ser Ser 
    1235                 1240                 1245             


Ser Lys  Ser Ala Leu His Ser  Ser Val Pro Lys Ser  Xaa Asn Asp 
    1250                 1255                 1260             


Arg Asp  Ala Xaa Pro Leu Ser  Arg Ala Met Asp Phe  Glu Gly Lys 
    1265                 1270                 1275             


Leu Gly  Cys Asp Ser Glu Ser  Asn Ser Xaa Leu Glu  Asn Ser Ser 
    1280                 1285                 1290             


Asp Xaa  Val Ser Ile Gln Asp  Ser Ser Glu Glu Asp  Met Ile Val 
    1295                 1300                 1305             


Gln Asn  Ser Asn Glu Ser Ile  Ser Glu Gln Phe Arg  Xaa Arg Glu 
    1310                 1315                 1320             


Gln Asp  Val Glu Val Leu Glu  Pro Leu Lys Cys Glu  Leu Val Ser 
    1325                 1330                 1335             


Gly Glu  Ser Xaa Gly Asn Cys  Glu Asp Arg Leu Pro  Val Lys Gly 
    1340                 1345                 1350             


Xaa Glu  Ala Asn Gly Lys Lys  Pro Ser Gln Gln Lys  Lys Leu Glu 
    1355                 1360                 1365             


Glu Arg  Pro Val Asn Lys Cys  Ser Asp Gln Ile Lys  Leu Lys Asn 
    1370                 1375                 1380             


Xaa Xaa  Asp Lys Lys Asn Asn  Glu Asn Arg Glu Ser  Glu Lys Lys 
    1385                 1390                 1395             


Gly Gln  Arg Xaa Ser Xaa Phe  Gln Ile Asn Gly Lys  Asp Asn Lys 
    1400                 1405                 1410             


Pro Lys  Ile Tyr Leu Lys Gly  Glu Cys Leu Lys Glu  Ile Ser Glu 
    1415                 1420                 1425             


Ser Arg  Val Val Ser Gly Asn  Val Glu Pro Lys Val  Asn Asn Ile 
    1430                 1435                 1440             


Asn Lys  Ile Ile Pro Glu Asn  Asp Ile Lys Ser Leu  Xaa Val Lys 
    1445                 1450                 1455             


Glu Ser  Ala Ile Arg Pro Phe  Ile Asn Gly Asp Val  Ile Met Glu 
    1460                 1465                 1470             


Asp Phe  Asn Glu Arg Asn Ser  Ser Glu Xaa Lys Ser  His Leu Leu 
    1475                 1480                 1485             


Ser Ser  Ser Asp Ala Glu Gly  Asn Tyr Arg Asp Ser  Leu Glu Xaa 
    1490                 1495                 1500             


Leu Pro  Ser Xaa Lys Glu Ser  Asp Ser Xaa Gln Xaa  Xaa Xaa Pro 
    1505                 1510                 1515             


Ser Ala  Ser Cys Pro Glu Ser  Asn Ser Val Asn Gln  Val Glu Asp 
    1520                 1525                 1530             


Met Glu  Ile Glu Xaa Ser Glu  Val Lys Lys Val Xaa  Ser Ser Pro 
    1535                 1540                 1545             


Ile Xaa  Ser Glu Glu Glu Ser  Asn Leu Ser Asn Asp  Phe Ile Asp 
    1550                 1555                 1560             


Glu Asn  Gly Leu Pro Ile Asn  Lys Asn Glu Asn Val  Asn Gly Glu 
    1565                 1570                 1575             


Ser Lys  Arg Lys Xaa Val Ile  Xaa Glu Val Xaa Xaa  Met Xaa Ser 
    1580                 1585                 1590             


Xaa Val  Ala Xaa Glu Ser Lys  Xaa Val Ile Lys Val  Glu Lys Gly 
    1595                 1600                 1605             


Asp Lys  Gln Xaa Val Val Ser  Ser Xaa Glu Asn Cys  Ala Lys Ser 
    1610                 1615                 1620             


Xaa Val  Xaa Xaa Xaa Xaa Xaa  Xaa Val Xaa Lys Leu  Ser Xaa Pro 
    1625                 1630                 1635             


Ser Xaa  Gly Gly Ser Val Asp  Ile Ile Ser Val Lys  Glu Gln Ser 
    1640                 1645                 1650             


Lys Xaa  Val Val Xaa Xaa Xaa  Val Xaa Asp Ser Leu  Xaa Xaa Xaa 
    1655                 1660                 1665             


Gly Gly  Xaa Leu Val Xaa Ser  Met Xaa Val Ser Lys  Glu Tyr Ser 
    1670                 1675                 1680             


Xaa Arg  Asp Lys Val Lys Leu  Met Lys Phe Ser Arg  Pro Lys Lys 
    1685                 1690                 1695             


Xaa Arg  Ser Gly Xaa Ala Leu  Pro Ser Tyr Arg Lys  Phe Val Xaa 
    1700                 1705                 1710             


Lys Ser  Ser Lys Lys Ser Ile  Phe Val Leu Pro Asn  Asp Asp Leu 
    1715                 1720                 1725             


Lys Lys  Leu Ala Arg Lys Gly  Gly Ile Arg Glu Val  Pro Tyr Phe 
    1730                 1735                 1740             


Asn Tyr  Asn Ala Lys Pro Ala  Leu Asp Ile Trp Pro  Tyr Pro Ser 
    1745                 1750                 1755             


Pro Arg  Pro Xaa Phe Gly Ile  Xaa Trp Arg Tyr Arg  Leu Gln Xaa 
    1760                 1765                 1770             


Val Lys  Ser Leu Ala Gly Val  Ser Leu Met Leu Arg  Leu Leu Trp 
    1775                 1780                 1785             


Ala Ser  Leu Arg Trp Asp Asp  Met Ala Ala Lys Ala  Pro Pro Gly 
    1790                 1795                 1800             


Gly Gly  Xaa Xaa Arg Xaa Glu  Xaa Ser Glu Xaa Glu  Ile Xaa Xaa 
    1805                 1810                 1815             


Xaa Glu  Ile Ile Lys Arg Arg  Asp Val Gly Pro Tyr  Gly Ile Arg 
    1820                 1825                 1830             


Ser Glu  Tyr Cys Ile Arg Lys  Ile Ile Cys Pro Ile  Gly Val Pro 
    1835                 1840                 1845             


Glu Xaa  Pro Lys Glu Xaa Pro  Xaa Pro Gln Arg Lys  Gly Leu Arg 
    1850                 1855                 1860             


Ser Ser  Ala Leu Arg Pro Lys  Arg Pro Glu Xaa Pro  Lys Gln Xaa 
    1865                 1870                 1875             


Gly Pro  Val Ile Ile Glu Xaa  Trp Val Ala Glu Glu  Glu Leu Glu 
    1880                 1885                 1890             


Leu Trp  Glu Ile Arg Ala Phe  Ala Glu Arg Val Glu  Lys Glu Lys 
    1895                 1900                 1905             


Ala Gln  Ala Val Glu Gln Gln  Ala Lys Lys Arg Leu  Glu Gln Gln 
    1910                 1915                 1920             


Lys Pro  Xaa Val Ile Ala Xaa  Ser Xaa Xaa Ser Pro  Xaa Ser Ser 
    1925                 1930                 1935             


Xaa Xaa  Ser Xaa Ile Ser Pro  Ala Gln Lys Val Met  Val Ala Pro 
    1940                 1945                 1950             


Ile Ser  Gly Ser Val Xaa Xaa  Gly Xaa Lys Met Val  Leu Xaa Xaa 
    1955                 1960                 1965             


Lys Val  Gly Ser Pro Ala Xaa  Val Xaa Phe Gln Gln  Asn Lys Asn 
    1970                 1975                 1980             


Phe His  Gln Xaa Phe Ala Xaa  Trp Val Lys Gln Gly  Gln Ser Asn 
    1985                 1990                 1995             


Ser Gly  Val Val Gln Val Gln  Gln Lys Val Leu Gly  Ile Ile Pro 
    2000                 2005                 2010             


Ser Ser  Xaa Gly Xaa Ser Gln  Gln Xaa Phe Xaa Ser  Phe Gln Pro 
    2015                 2020                 2025             


Arg Xaa  Ala Xaa Val Xaa Ile  Arg Pro Asn Xaa Ser  Gly Ser Gly 
    2030                 2035                 2040             


Gly Xaa  Xaa Ser Asn Ser Gln  Val Ile Xaa Gly Pro  Gln Ile Arg 
    2045                 2050                 2055             


Pro Gly  Met Xaa Val Ile Arg  Xaa Pro Leu Gln Gln  Ser Xaa Leu 
    2060                 2065                 2070             


Gly Lys  Ala Ile Ile Arg Xaa  Pro Val Met Val Gln  Pro Gly Ala 
    2075                 2080                 2085             


Pro Gln  Gln Val Met Xaa Gln  Ile Ile Arg Gly Gln  Pro Val Ser 
    2090                 2095                 2100             


Xaa Ala  Val Ser Ala Pro Asn  Xaa Val Ser Ser Xaa  Pro Gly Gln 
    2105                 2110                 2115             


Lys Ser  Leu Xaa Ser Ala Xaa  Ser Xaa Ser Asn Ile  Gln Ser Ser 
    2120                 2125                 2130             


Ala Ser  Gln Pro Pro Arg Pro  Gln Gln Gly Gln Val  Lys Leu Xaa 
    2135                 2140                 2145             


Met Ala  Gln Leu Xaa Gln Leu  Xaa Gln Gly His Gly  Gly Asn Gln 
    2150                 2155                 2160             


Gly Leu  Xaa Val Val Ile Gln  Gly Gln Gly Gln Xaa  Xaa Gly Gln 
    2165                 2170                 2175             


Leu Gln  Leu Ile Pro Gln Gly  Val Xaa Val Leu Pro  Gly Pro Gly 
    2180                 2185                 2190             


Gln Gln  Leu Met Gln Ala Ala  Met Pro Asn Gly Xaa  Val Gln Arg 
    2195                 2200                 2205             


Phe Leu  Phe Xaa Pro Leu Ala  Xaa Xaa Ala Xaa Xaa  Ala Ser Xaa 
    2210                 2215                 2220             


Xaa Xaa  Xaa Xaa Val Ser Xaa  Xaa Ala Ala Gly Xaa  Gly Glu Gln 
    2225                 2230                 2235             


Arg Gln  Ser Lys Leu Ser Pro  Gln Met Gln Val His  Gln Asp Lys 
    2240                 2245                 2250             


Xaa Leu  Pro Pro Ala Gln Ser  Ser Ser Val Gly Pro  Ala Glu Ala 
    2255                 2260                 2265             


Gln Pro  Gln Xaa Ala Gln Pro  Ser Ala Gln Pro Gln  Pro Gln Xaa 
    2270                 2275                 2280             


Gln Pro  Gln Ser Pro Ala Gln  Pro Glu Val Gln Xaa  Gln Pro Glu 
    2285                 2290                 2295             


Val Gln  Xaa Gln Xaa Xaa Val  Ser Ser His Val Pro  Ser Glu Ala 
    2300                 2305                 2310             


Gln Pro  Xaa His Ala Gln Ser  Ser Lys Pro Gln Val  Ala Ala Gln 
    2315                 2320                 2325             


Ser Gln  Pro Gln Ser Asn Val  Gln Gly Gln Ser Pro  Val Arg Val 
    2330                 2335                 2340             


Gln Ser  Pro Ser Gln Xaa Arg  Ile Arg Pro Ser Xaa  Pro Ser Gln 
    2345                 2350                 2355             


Leu Ser  Pro Gly Gln Gln Ser  Gln Val Gln Xaa Xaa  Xaa Ser Gln 
    2360                 2365                 2370             


Pro Ile  Pro Ile Gln Pro His  Xaa Ser Leu Gln Ile  Pro Ser Gln 
    2375                 2380                 2385             


Gly Gln  Pro Gln Ser Gln Pro  Gln Val Gln Ser Ser  Xaa Gln Xaa 
    2390                 2395                 2400             


Leu Ser  Ser Gly Gln Xaa Leu  Asn Gln Val Xaa Val  Ser Ser Pro 
    2405                 2410                 2415             


Ser Arg  Pro Gln Leu Gln Ile  Gln Gln Pro Gln Pro  Gln Val Ile 
    2420                 2425                 2430             


Ala Val  Pro Gln Leu Gln Gln  Gln Val Gln Val Leu  Ser Gln Ile 
    2435                 2440                 2445             


Gln Ser  Gln Val Val Ala Gln  Ile Gln Ala Gln Gln  Ser Gly Val 
    2450                 2455                 2460             


Pro Gln  Gln Ile Lys Leu Gln  Leu Pro Ile Gln Ile  Gln Gln Ser 
    2465                 2470                 2475             


Ser Ala  Val Gln Xaa His Gln  Ile Gln Asn Val Val  Xaa Val Gln 
    2480                 2485                 2490             


Ala Ala  Ser Val Gln Glu Gln  Leu Gln Arg Val Gln  Gln Leu Arg 
    2495                 2500                 2505             


Asp Gln  Gln Gln Lys Lys Lys  Gln Gln Gln Ile Glu  Ile Lys Arg 
    2510                 2515                 2520             


Glu His  Xaa Leu Gln Ala Ser  Asn Gln Ser Glu Ile  Ile Gln Lys 
    2525                 2530                 2535             


Gln Val  Val Met Lys His Asn  Ala Val Ile Glu His  Leu Lys Gln 
    2540                 2545                 2550             


Lys Lys  Ser Met Xaa Pro Ala  Glu Arg Glu Glu Asn  Gln Arg Met 
    2555                 2560                 2565             


Ile Val  Cys Asn Gln Val Met  Lys Tyr Ile Leu Asp  Lys Ile Asp 
    2570                 2575                 2580             


Lys Glu  Glu Lys Gln Ala Ala  Lys Lys Arg Lys Arg  Glu Glu Ser 
    2585                 2590                 2595             


Val Glu  Gln Lys Arg Ser Lys  Gln Asn Ala Xaa Lys  Leu Ser Ala 
    2600                 2605                 2610             


Leu Leu  Phe Lys His Lys Glu  Gln Leu Arg Ala Glu  Ile Leu Lys 
    2615                 2620                 2625             


Lys Arg  Ala Leu Leu Asp Lys  Asp Leu Gln Ile Glu  Val Gln Glu 
    2630                 2635                 2640             


Glu Leu  Lys Arg Asp Leu Lys  Ile Lys Lys Glu Lys  Asp Leu Met 
    2645                 2650                 2655             


Gln Leu  Ala Gln Ala Xaa Ala  Val Ala Ala Pro Cys  Pro Pro Val 
    2660                 2665                 2670             


Xaa Pro  Ala Pro Pro Ala Pro  Pro Ala Pro Pro Pro  Ser Pro Pro 
    2675                 2680                 2685             


Pro Pro  Pro Ala Val Gln His  Xaa Gly Leu Leu Ser  Xaa Pro Xaa 
    2690                 2695                 2700             


Leu Pro  Ala Ala Ser Gln Lys  Arg Lys Arg Glu Glu  Glu Lys Asp 
    2705                 2710                 2715             


Ser Ser  Ser Lys Ser Lys Lys  Lys Lys Met Ile Ser  Xaa Xaa Ser 
    2720                 2725                 2730             


Lys Glu  Xaa Lys Lys Asp Xaa  Lys Leu Tyr Cys Ile  Cys Lys Xaa 
    2735                 2740                 2745             


Pro Tyr  Asp Glu Ser Lys Phe  Tyr Ile Gly Cys Asp  Arg Cys Gln 
    2750                 2755                 2760             


Asn Trp  Tyr His Gly Arg Cys  Val Gly Ile Leu Gln  Ser Glu Ala 
    2765                 2770                 2775             


Glu Leu  Ile Asp Glu Tyr Val  Cys Pro Gln Cys Gln  Ser Xaa Glu 
    2780                 2785                 2790             


Asp Ala  Met Xaa Val Leu Xaa  Pro Leu Xaa Glu Lys  Asp Tyr Glu 
    2795                 2800                 2805             


Gly Leu  Lys Arg Val Leu Arg  Ser Leu Gln Ala His  Lys Met Ala 
    2810                 2815                 2820             


Trp Pro  Phe Leu Glu Pro Val  Asp Pro Asn Asp Ala  Pro Asp Tyr 
    2825                 2830                 2835             


Tyr Gly  Val Ile Lys Glu Pro  Met Asp Leu Ala Xaa  Met Glu Glu 
    2840                 2845                 2850             


Arg Val  Gln Arg Arg Tyr Tyr  Glu Lys Leu Xaa Glu  Phe Val Ala 
    2855                 2860                 2865             


Asp Met  Xaa Lys Ile Phe Asp  Asn Cys Arg Tyr Tyr  Asn Pro Ser 
    2870                 2875                 2880             


Asp Ser  Pro Phe Tyr Gln Cys  Ala Glu Val Leu Glu  Ser Phe Phe 
    2885                 2890                 2895             


Val Gln  Lys Leu Lys Gly Phe  Lys Ala Ser Arg Ser  His Asn Asn 
    2900                 2905                 2910             


Lys Leu  Gln Ser Xaa Ala Ser  
    2915                 2920 


<210> 4332
<211> 3046
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1222)..(1222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1235)..(1235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1282)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1354)..(1354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1387)..(1387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1393)..(1393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1421)..(1421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1447)..(1447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1480)..(1480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1510)..(1511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1528)..(1528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1530)..(1530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1629)..(1629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1639)..(1639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1641)..(1643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1664)..(1664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1671)..(1671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1676)..(1676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1709)..(1709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1712)..(1712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1715)..(1716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1718)..(1718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1720)..(1720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1723)..(1723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1727)..(1727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1738)..(1738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1743)..(1743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1750)..(1750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1752)..(1757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1759)..(1759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1763)..(1763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1766)..(1766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1781)..(1781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1784)..(1786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1788)..(1788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1792)..(1794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1797)..(1797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1800)..(1800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1803)..(1803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1810)..(1810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1825)..(1825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1829)..(1829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1839)..(1839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1888)..(1888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1892)..(1892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1899)..(1899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1932)..(1933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1935)..(1935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1937)..(1937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1940)..(1940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1943)..(1945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1976)..(1976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1980)..(1980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1982)..(1982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2000)..(2000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2004)..(2004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2011)..(2011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2052)..(2052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2056)..(2056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2058)..(2059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2062)..(2062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2065)..(2066)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2068)..(2068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2085)..(2086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2088)..(2088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2093)..(2094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2101)..(2101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2103)..(2103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2113)..(2113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2116)..(2116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2142)..(2142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2144)..(2144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2148)..(2148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2150)..(2150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2156)..(2156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2158)..(2158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2160)..(2160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2165)..(2165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2171)..(2172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2179)..(2179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2188)..(2188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2192)..(2192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2198)..(2198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2206)..(2206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2220)..(2220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2230)..(2230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2237)..(2237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2241)..(2241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2248)..(2248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2251)..(2251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2253)..(2253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2274)..(2274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2279)..(2279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2282)..(2282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2292)..(2292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2301)..(2302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2313)..(2313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2331)..(2331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2338)..(2338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2342)..(2343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2345)..(2346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2349)..(2353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2356)..(2357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2361)..(2361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2380)..(2380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2398)..(2398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2409)..(2409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2421)..(2421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2427)..(2427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2429)..(2430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2442)..(2442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2475)..(2475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2481)..(2481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2495)..(2497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2507)..(2507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2527)..(2527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2529)..(2529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2535)..(2535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2540)..(2540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2609)..(2609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2617)..(2617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2652)..(2652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2684)..(2684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2735)..(2735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2790)..(2790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2800)..(2800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2822)..(2822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2827)..(2827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2829)..(2829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2857)..(2858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2862)..(2862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2866)..(2866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2874)..(2874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2918)..(2918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2923)..(2923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2926)..(2926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2929)..(2929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2976)..(2976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2990)..(2990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2997)..(2997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3044)..(3044)
<223> Selenocysteine

<400> 4332
Met Arg Gly Arg Arg Gly Arg Pro Pro Lys Gln Pro Ala Ala Pro Ala 
1               5                   10                  15      


Ala Glu Arg Cys Ala Pro Ala Pro Pro Pro Pro Pro Pro Pro Pro Xaa 
            20                  25                  30          


Ser Gly Pro Ile Gly Gly Leu Arg Ser Arg His Arg Gly Ser Ser Arg 
        35                  40                  45              


Gly Arg Trp Ala Ala Ala Gln Ala Glu Val Ala Pro Lys Xaa Arg Leu 
    50                  55                  60                  


Ser Ser Pro Arg Gly Gly Ser Ser Ser Arg Arg Lys Pro Pro Pro Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Pro Ser Xaa Ser Ala Pro Gly Arg Gly Gly Arg Gly 
                85                  90                  95      


Gly Gly Gly Gly Arg Xaa Gly Gly Gly Gly Gly Gly Gly His Leu Ala 
            100                 105                 110         


Arg Xaa Xaa Ala Ala Arg Arg Ala Val Asn Lys Val Val Tyr Asp Asp 
        115                 120                 125             


His Glu Ser Glu Glu Glu Glu Glu Glu Glu Asp Met Val Ser Glu Glu 
    130                 135                 140                 


Glu Glu Glu Glu Asp Gly Asp Ala Glu Glu Xaa Gln Asp Ser Glu Asp 
145                 150                 155                 160 


Asp Glu Glu Asp Glu Met Glu Glu Asp Asp Asp Asp Ser Asp Tyr Pro 
                165                 170                 175     


Glu Glu Met Glu Asp Asp Asp Asp Asp Ala Ser Tyr Cys Xaa Glu Ser 
            180                 185                 190         


Ser Phe Arg Ser His Ser Xaa Tyr Ser Ser Xaa Pro Gly Arg Arg Lys 
        195                 200                 205             


Pro Arg Val His Arg Pro Arg Ser Pro Ile Leu Glu Glu Lys Asp Ile 
    210                 215                 220                 


Pro Pro Leu Glu Phe Pro Lys Ser Ser Glu Asp Leu Met Val Pro Asn 
225                 230                 235                 240 


Glu His Ile Met Asn Val Ile Ala Ile Tyr Glu Val Leu Arg Asn Phe 
                245                 250                 255     


Gly Xaa Val Leu Arg Leu Ser Pro Phe Arg Phe Glu Asp Phe Cys Ala 
            260                 265                 270         


Ala Leu Val Ser Gln Glu Gln Cys Xaa Leu Met Ala Glu Met His Val 
        275                 280                 285             


Val Leu Leu Lys Ala Val Leu Arg Glu Glu Asp Xaa Ser Asn Xaa Xaa 
    290                 295                 300                 


Phe Gly Pro Ala Asp Leu Lys Asp Ser Val Asn Ser Xaa Leu Tyr Phe 
305                 310                 315                 320 


Ile Asp Gly Met Xaa Trp Pro Glu Val Leu Arg Val Tyr Cys Glu Ser 
                325                 330                 335     


Asp Lys Glu Tyr His His Val Leu Pro Tyr Gln Glu Ala Glu Asp Tyr 
            340                 345                 350         


Pro Tyr Gly Pro Val Glu Asn Lys Ile Lys Val Leu Gln Phe Leu Val 
        355                 360                 365             


Asp Gln Phe Leu Xaa Xaa Asn Ile Ala Arg Glu Glu Leu Met Ser Glu 
    370                 375                 380                 


Gly Val Ile Gln Tyr Asp Asp His Cys Arg Val Cys His Lys Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Cys Cys Glu Xaa Cys Ser Ala Val Tyr His Leu Glu Cys 
                405                 410                 415     


Val Lys Pro Pro Leu Glu Glu Val Pro Glu Asp Glu Trp Gln Cys Glu 
            420                 425                 430         


Val Cys Val Ala His Lys Val Pro Gly Val Xaa Asp Cys Val Ala Glu 
        435                 440                 445             


Ile Gln Lys Asn Lys Pro Tyr Ile Arg His Glu Pro Ile Gly Tyr Asp 
    450                 455                 460                 


Arg Ser Arg Arg Lys Tyr Trp Phe Leu Asn Arg Arg Leu Ile Ile Glu 
465                 470                 475                 480 


Glu Asp Xaa Glu Asn Glu Asn Glu Lys Lys Ile Trp Tyr Tyr Ser Xaa 
                485                 490                 495     


Lys Val Gln Leu Ala Glu Leu Ile Asp Cys Leu Asp Lys Asp Tyr Trp 
            500                 505                 510         


Glu Ala Glu Leu Cys Lys Ile Leu Glu Glu Met Arg Glu Glu Ile His 
        515                 520                 525             


Arg His Met Asp Ile Xaa Glu Asp Leu Xaa Asn Lys Ala Arg Gly Ser 
    530                 535                 540                 


Asn Lys Ser Phe Leu Ala Ala Ala Asn Glu Glu Ile Leu Glu Ser Ile 
545                 550                 555                 560 


Arg Ala Lys Lys Gly Asp Ile Asp Asn Val Lys Ser Pro Glu Glu Xaa 
                565                 570                 575     


Glu Lys Asp Lys Asn Glu Xaa Glu Asn Asp Ser Lys Asp Ala Glu Lys 
            580                 585                 590         


Asn Arg Glu Glu Phe Glu Asp Gln Ser Leu Glu Lys Asp Ser Asp Asp 
        595                 600                 605             


Lys Xaa Pro Asp Asp Asp Pro Glu Gln Gly Lys Ser Glu Glu Pro Xaa 
    610                 615                 620                 


Glu Val Gly Asp Lys Gly Asn Ser Val Ser Ala Asn Leu Gly Asp Asn 
625                 630                 635                 640 


Xaa Xaa Asn Ala Xaa Ser Glu Glu Xaa Ser Pro Ser Glu Gly Arg Ser 
                645                 650                 655     


Pro Val Gly Cys Leu Ser Glu Xaa Pro Asp Ser Ser Asn Met Ala Glu 
            660                 665                 670         


Lys Lys Val Ala Ser Glu Leu Pro Gln Asp Val Pro Glu Glu Pro Asn 
        675                 680                 685             


Lys Xaa Cys Glu Ser Ser Asn Xaa Ser Ala Xaa Xaa Xaa Ser Ile Gln 
    690                 695                 700                 


Pro Asn Leu Glu Asn Ser Asn Ser Ser Ser Glu Leu Asn Ser Ser Gln 
705                 710                 715                 720 


Ser Glu Ser Ala Lys Ala Ala Asp Asp Pro Glu Asn Gly Glu Arg Glu 
                725                 730                 735     


Ser His Xaa Pro Val Ser Ile Gln Glu Glu Ile Val Gly Asp Phe Lys 
            740                 745                 750         


Ser Glu Lys Ser Asn Gly Glu Leu Ser Glu Ser Pro Gly Ala Gly Lys 
        755                 760                 765             


Gly Ala Ser Gly Ser Xaa Arg Ile Ile Xaa Arg Leu Arg Asn Pro Asp 
    770                 775                 780                 


Ser Lys Leu Ser Gln Leu Lys Ser Gln Gln Val Ala Ala Ala Ala His 
785                 790                 795                 800 


Glu Ala Asn Lys Leu Phe Lys Glu Gly Lys Glu Val Leu Val Val Asn 
                805                 810                 815     


Ser Gln Gly Glu Ile Ser Arg Leu Ser Xaa Lys Lys Glu Val Ile Met 
            820                 825                 830         


Lys Gly Asn Ile Asn Asn Tyr Phe Lys Leu Gly Gln Glu Gly Lys Tyr 
        835                 840                 845             


Arg Val Tyr His Asn Gln Tyr Ser Xaa Asn Ser Phe Ala Leu Asn Lys 
    850                 855                 860                 


His Gln His Arg Glu Asp His Asp Lys Arg Arg His Leu Ala His Lys 
865                 870                 875                 880 


Phe Cys Leu Xaa Pro Ala Gly Glu Phe Lys Trp Asn Gly Ser Val His 
                885                 890                 895     


Gly Ser Lys Val Leu Xaa Ile Ser Xaa Leu Arg Leu Xaa Ile Xaa Gln 
            900                 905                 910         


Leu Glu Asn Asn Ile Pro Ser Ser Phe Leu His Pro Asn Trp Ala Ser 
        915                 920                 925             


His Arg Ala Asn Trp Ile Lys Ala Val Gln Met Cys Ser Lys Pro Arg 
    930                 935                 940                 


Glu Phe Ala Leu Ala Leu Ala Ile Leu Glu Cys Ala Val Lys Pro Val 
945                 950                 955                 960 


Val Met Leu Pro Ile Trp Arg Glu Ser Leu Gly His Xaa Arg Leu His 
                965                 970                 975     


Arg Met Xaa Ser Ile Glu Arg Glu Glu Lys Glu Lys Val Lys Lys Lys 
            980                 985                 990         


Glu Lys Lys Gln Glu Glu Glu Glu  Xaa Met Gln Gln Ala  Xaa Trp Val 
        995                 1000                 1005             


Lys Tyr  Xaa Phe Pro Val Lys  His Gln Val Trp Lys  Gln Lys Gly 
    1010                 1015                 1020             


Glu Glu  Tyr Arg Val Xaa Gly  Tyr Gly Gly Trp Ser  Trp Ile Ser 
    1025                 1030                 1035             


Lys Xaa  His Val Tyr Arg Phe  Val Pro Lys Leu Pro  Gly Asn Xaa 
    1040                 1045                 1050             


Asn Val  Asn Tyr Arg Lys Ser  Leu Glu Gly Xaa Lys  Asn Asn Met 
    1055                 1060                 1065             


Asp Glu  Asn Met Asp Glu Ser  Asp Lys Arg Lys Cys  Ser Arg Ser 
    1070                 1075                 1080             


Pro Lys  Lys Ile Lys Ile Glu  Pro Asp Ser Glu Lys  Asp Glu Val 
    1085                 1090                 1095             


Lys Gly  Ser Asp Ala Ala Lys  Gly Ala Asp Gln Asn  Glu Met Asp 
    1100                 1105                 1110             


Ile Ser  Lys Ile Xaa Glu Lys  Lys Asp Gln Asp Val  Lys Glu Leu 
    1115                 1120                 1125             


Leu Asp  Ser Asp Ser Asp Lys  Pro Cys Lys Glu Glu  Pro Met Glu 
    1130                 1135                 1140             


Val Asp  Asp Asp Met Lys Xaa  Glu Ser His Val Asn  Cys Gln Glu 
    1145                 1150                 1155             


Ser Ser  Gln Val Asp Val Val  Asn Val Ser Glu Gly  Phe His Leu 
    1160                 1165                 1170             


Arg Xaa  Ser Tyr Lys Lys Lys  Xaa Lys Ser Ser Lys  Leu Asp Gly 
    1175                 1180                 1185             


Leu Leu  Glu Arg Arg Ile Lys  Gln Phe Xaa Leu Glu  Glu Lys Gln 
    1190                 1195                 1200             


Arg Leu  Glu Lys Ile Lys Leu  Glu Gly Gly Ile Lys  Gly Ile Gly 
    1205                 1210                 1215             


Lys Xaa  Ser Xaa Asn Ser Ser  Lys Asn Leu Ser Glu  Ser Pro Val 
    1220                 1225                 1230             


Ile Xaa  Lys Ala Lys Glu Gly  Cys Gln Ser Asp Ser  Met Arg Gln 
    1235                 1240                 1245             


Glu Gln  Ser Pro Asn Ala Asn  Asn Asp Gln Pro Glu  Asp Leu Ile 
    1250                 1255                 1260             


Gln Gly  Cys Ser Glu Ser Asp  Ser Ser Val Leu Arg  Met Ser Asp 
    1265                 1270                 1275             


Pro Ser  His Xaa Xaa Asn Lys  Leu Tyr Pro Lys Asp  Arg Val Leu 
    1280                 1285                 1290             


Asp Asp  Val Ser Ile Arg Ser  Pro Glu Xaa Lys Cys  Pro Lys Gln 
    1295                 1300                 1305             


Asn Ser  Ile Glu Asn Asp Ile  Glu Glu Lys Val Ser  Asp Leu Ala 
    1310                 1315                 1320             


Ser Arg  Gly Gln Glu Pro Ser  Lys Ser Lys Xaa Lys  Gly Asn Asp 
    1325                 1330                 1335             


Phe Phe  Ile Asp Asp Ser Lys  Leu Ala Ser Ala Asp  Asp Ile Gly 
    1340                 1345                 1350             


Xaa Leu  Ile Cys Lys Asn Lys  Lys Pro Leu Ile Gln  Glu Glu Ser 
    1355                 1360                 1365             


Asp Xaa  Ile Val Ser Ser Ser  Lys Ser Ala Leu His  Ser Ser Val 
    1370                 1375                 1380             


Pro Lys  Ser Xaa Asn Asp Arg  Asp Ala Xaa Pro Leu  Ser Arg Ala 
    1385                 1390                 1395             


Met Asp  Phe Glu Gly Lys Leu  Gly Cys Asp Ser Glu  Ser Asn Ser 
    1400                 1405                 1410             


Xaa Leu  Glu Asn Ser Ser Asp  Xaa Val Ser Ile Gln  Asp Ser Ser 
    1415                 1420                 1425             


Glu Glu  Asp Met Ile Val Gln  Asn Ser Asn Glu Ser  Ile Ser Glu 
    1430                 1435                 1440             


Gln Phe  Arg Xaa Arg Glu Gln  Asp Val Glu Val Leu  Glu Pro Leu 
    1445                 1450                 1455             


Lys Cys  Glu Leu Val Ser Gly  Glu Ser Xaa Gly Asn  Cys Glu Asp 
    1460                 1465                 1470             


Arg Leu  Pro Val Lys Gly Xaa  Glu Ala Asn Gly Lys  Lys Pro Ser 
    1475                 1480                 1485             


Gln Gln  Lys Lys Leu Glu Glu  Arg Pro Val Asn Lys  Cys Ser Asp 
    1490                 1495                 1500             


Gln Ile  Lys Leu Lys Asn Xaa  Xaa Asp Lys Lys Asn  Asn Glu Asn 
    1505                 1510                 1515             


Arg Glu  Ser Glu Lys Lys Gly  Gln Arg Xaa Ser Xaa  Phe Gln Ile 
    1520                 1525                 1530             


Asn Gly  Lys Asp Asn Lys Pro  Lys Ile Tyr Leu Lys  Gly Glu Cys 
    1535                 1540                 1545             


Leu Lys  Glu Ile Ser Glu Ser  Arg Val Val Ser Gly  Asn Val Glu 
    1550                 1555                 1560             


Pro Lys  Val Asn Asn Ile Asn  Lys Ile Ile Pro Glu  Asn Asp Ile 
    1565                 1570                 1575             


Lys Ser  Leu Xaa Val Lys Glu  Ser Ala Ile Arg Pro  Phe Ile Asn 
    1580                 1585                 1590             


Gly Asp  Val Ile Met Glu Asp  Phe Asn Glu Arg Asn  Ser Ser Glu 
    1595                 1600                 1605             


Xaa Lys  Ser His Leu Leu Ser  Ser Ser Asp Ala Glu  Gly Asn Tyr 
    1610                 1615                 1620             


Arg Asp  Ser Leu Glu Xaa Leu  Pro Ser Xaa Lys Glu  Ser Asp Ser 
    1625                 1630                 1635             


Xaa Gln  Xaa Xaa Xaa Pro Ser  Ala Ser Cys Pro Glu  Ser Asn Ser 
    1640                 1645                 1650             


Val Asn  Gln Val Glu Asp Met  Glu Ile Glu Xaa Ser  Glu Val Lys 
    1655                 1660                 1665             


Lys Val  Xaa Ser Ser Pro Ile  Xaa Ser Glu Glu Glu  Ser Asn Leu 
    1670                 1675                 1680             


Ser Asn  Asp Phe Ile Asp Glu  Asn Gly Leu Pro Ile  Asn Lys Asn 
    1685                 1690                 1695             


Glu Asn  Val Asn Gly Glu Ser  Lys Arg Lys Xaa Val  Ile Xaa Glu 
    1700                 1705                 1710             


Val Xaa  Xaa Met Xaa Ser Xaa  Val Ala Xaa Glu Ser  Lys Xaa Val 
    1715                 1720                 1725             


Ile Lys  Val Glu Lys Gly Asp  Lys Gln Xaa Val Val  Ser Ser Xaa 
    1730                 1735                 1740             


Glu Asn  Cys Ala Lys Ser Xaa  Val Xaa Xaa Xaa Xaa  Xaa Xaa Val 
    1745                 1750                 1755             


Xaa Lys  Leu Ser Xaa Pro Ser  Xaa Gly Gly Ser Val  Asp Ile Ile 
    1760                 1765                 1770             


Ser Val  Lys Glu Gln Ser Lys  Xaa Val Val Xaa Xaa  Xaa Val Xaa 
    1775                 1780                 1785             


Asp Ser  Leu Xaa Xaa Xaa Gly  Gly Xaa Leu Val Xaa  Ser Met Xaa 
    1790                 1795                 1800             


Val Ser  Lys Glu Tyr Ser Xaa  Arg Asp Lys Val Lys  Leu Met Lys 
    1805                 1810                 1815             


Phe Ser  Arg Pro Lys Lys Xaa  Arg Ser Gly Xaa Ala  Leu Pro Ser 
    1820                 1825                 1830             


Tyr Arg  Lys Phe Val Xaa Lys  Ser Ser Lys Lys Ser  Ile Phe Val 
    1835                 1840                 1845             


Leu Pro  Asn Asp Asp Leu Lys  Lys Leu Ala Arg Lys  Gly Gly Ile 
    1850                 1855                 1860             


Arg Glu  Val Pro Tyr Phe Asn  Tyr Asn Ala Lys Pro  Ala Leu Asp 
    1865                 1870                 1875             


Ile Trp  Pro Tyr Pro Ser Pro  Arg Pro Xaa Phe Gly  Ile Xaa Trp 
    1880                 1885                 1890             


Arg Tyr  Arg Leu Gln Xaa Val  Lys Ser Leu Ala Gly  Val Ser Leu 
    1895                 1900                 1905             


Met Leu  Arg Leu Leu Trp Ala  Ser Leu Arg Trp Asp  Asp Met Ala 
    1910                 1915                 1920             


Ala Lys  Ala Pro Pro Gly Gly  Gly Xaa Xaa Arg Xaa  Glu Xaa Ser 
    1925                 1930                 1935             


Glu Xaa  Glu Ile Xaa Xaa Xaa  Glu Ile Ile Lys Arg  Arg Asp Val 
    1940                 1945                 1950             


Gly Pro  Tyr Gly Ile Arg Ser  Glu Tyr Cys Ile Arg  Lys Ile Ile 
    1955                 1960                 1965             


Cys Pro  Ile Gly Val Pro Glu  Xaa Pro Lys Glu Xaa  Pro Xaa Pro 
    1970                 1975                 1980             


Gln Arg  Lys Gly Leu Arg Ser  Ser Ala Leu Arg Pro  Lys Arg Pro 
    1985                 1990                 1995             


Glu Xaa  Pro Lys Gln Xaa Gly  Pro Val Ile Ile Glu  Xaa Trp Val 
    2000                 2005                 2010             


Ala Glu  Glu Glu Leu Glu Leu  Trp Glu Ile Arg Ala  Phe Ala Glu 
    2015                 2020                 2025             


Arg Val  Glu Lys Glu Lys Ala  Gln Ala Val Glu Gln  Gln Ala Lys 
    2030                 2035                 2040             


Lys Arg  Leu Glu Gln Gln Lys  Pro Xaa Val Ile Ala  Xaa Ser Xaa 
    2045                 2050                 2055             


Xaa Ser  Pro Xaa Ser Ser Xaa  Xaa Ser Xaa Ile Ser  Pro Ala Gln 
    2060                 2065                 2070             


Lys Val  Met Val Ala Pro Ile  Ser Gly Ser Val Xaa  Xaa Gly Xaa 
    2075                 2080                 2085             


Lys Met  Val Leu Xaa Xaa Lys  Val Gly Ser Pro Ala  Xaa Val Xaa 
    2090                 2095                 2100             


Phe Gln  Gln Asn Lys Asn Phe  His Gln Xaa Phe Ala  Xaa Trp Val 
    2105                 2110                 2115             


Lys Gln  Gly Gln Ser Asn Ser  Gly Val Val Gln Val  Gln Gln Lys 
    2120                 2125                 2130             


Val Leu  Gly Ile Ile Pro Ser  Ser Xaa Gly Xaa Ser  Gln Gln Xaa 
    2135                 2140                 2145             


Phe Xaa  Ser Phe Gln Pro Arg  Xaa Ala Xaa Val Xaa  Ile Arg Pro 
    2150                 2155                 2160             


Asn Xaa  Ser Gly Ser Gly Gly  Xaa Xaa Ser Asn Ser  Gln Val Ile 
    2165                 2170                 2175             


Xaa Gly  Pro Gln Ile Arg Pro  Gly Met Xaa Val Ile  Arg Xaa Pro 
    2180                 2185                 2190             


Leu Gln  Gln Ser Xaa Leu Gly  Lys Ala Ile Ile Arg  Xaa Pro Val 
    2195                 2200                 2205             


Met Val  Gln Pro Gly Ala Pro  Gln Gln Val Met Xaa  Gln Ile Ile 
    2210                 2215                 2220             


Arg Gly  Gln Pro Val Ser Xaa  Ala Val Ser Ala Pro  Asn Xaa Val 
    2225                 2230                 2235             


Ser Ser  Xaa Pro Gly Gln Lys  Ser Leu Xaa Ser Ala  Xaa Ser Xaa 
    2240                 2245                 2250             


Ser Asn  Ile Gln Ser Ser Ala  Ser Gln Pro Pro Arg  Pro Gln Gln 
    2255                 2260                 2265             


Gly Gln  Val Lys Leu Xaa Met  Ala Gln Leu Xaa Gln  Leu Xaa Gln 
    2270                 2275                 2280             


Gly His  Gly Gly Asn Gln Gly  Leu Xaa Val Val Ile  Gln Gly Gln 
    2285                 2290                 2295             


Gly Gln  Xaa Xaa Gly Gln Leu  Gln Leu Ile Pro Gln  Gly Val Xaa 
    2300                 2305                 2310             


Val Leu  Pro Gly Pro Gly Gln  Gln Leu Met Gln Ala  Ala Met Pro 
    2315                 2320                 2325             


Asn Gly  Xaa Val Gln Arg Phe  Leu Phe Xaa Pro Leu  Ala Xaa Xaa 
    2330                 2335                 2340             


Ala Xaa  Xaa Ala Ser Xaa Xaa  Xaa Xaa Xaa Val Ser  Xaa Xaa Ala 
    2345                 2350                 2355             


Ala Gly  Xaa Gly Glu Gln Arg  Gln Ser Lys Leu Ser  Pro Gln Met 
    2360                 2365                 2370             


Gln Val  His Gln Asp Lys Xaa  Leu Pro Pro Ala Gln  Ser Ser Ser 
    2375                 2380                 2385             


Val Gly  Pro Ala Glu Ala Gln  Pro Gln Xaa Ala Gln  Pro Ser Ala 
    2390                 2395                 2400             


Gln Pro  Gln Pro Gln Xaa Gln  Pro Gln Ser Pro Ala  Gln Pro Glu 
    2405                 2410                 2415             


Val Gln  Xaa Gln Pro Glu Val  Gln Xaa Gln Xaa Xaa  Val Ser Ser 
    2420                 2425                 2430             


His Val  Pro Ser Glu Ala Gln  Pro Xaa His Ala Gln  Ser Ser Lys 
    2435                 2440                 2445             


Pro Gln  Val Ala Ala Gln Ser  Gln Pro Gln Ser Asn  Val Gln Gly 
    2450                 2455                 2460             


Gln Ser  Pro Val Arg Val Gln  Ser Pro Ser Gln Xaa  Arg Ile Arg 
    2465                 2470                 2475             


Pro Ser  Xaa Pro Ser Gln Leu  Ser Pro Gly Gln Gln  Ser Gln Val 
    2480                 2485                 2490             


Gln Xaa  Xaa Xaa Ser Gln Pro  Ile Pro Ile Gln Pro  His Xaa Ser 
    2495                 2500                 2505             


Leu Gln  Ile Pro Ser Gln Gly  Gln Pro Gln Ser Gln  Pro Gln Val 
    2510                 2515                 2520             


Gln Ser  Ser Xaa Gln Xaa Leu  Ser Ser Gly Gln Xaa  Leu Asn Gln 
    2525                 2530                 2535             


Val Xaa  Val Ser Ser Pro Ser  Arg Pro Gln Leu Gln  Ile Gln Gln 
    2540                 2545                 2550             


Pro Gln  Pro Gln Val Ile Ala  Val Pro Gln Leu Gln  Gln Gln Val 
    2555                 2560                 2565             


Gln Val  Leu Ser Gln Ile Gln  Ser Gln Val Val Ala  Gln Ile Gln 
    2570                 2575                 2580             


Ala Gln  Gln Ser Gly Val Pro  Gln Gln Ile Lys Leu  Gln Leu Pro 
    2585                 2590                 2595             


Ile Gln  Ile Gln Gln Ser Ser  Ala Val Gln Xaa His  Gln Ile Gln 
    2600                 2605                 2610             


Asn Val  Val Xaa Val Gln Ala  Ala Ser Val Gln Glu  Gln Leu Gln 
    2615                 2620                 2625             


Arg Val  Gln Gln Leu Arg Asp  Gln Gln Gln Lys Lys  Lys Gln Gln 
    2630                 2635                 2640             


Gln Ile  Glu Ile Lys Arg Glu  His Xaa Leu Gln Ala  Ser Asn Gln 
    2645                 2650                 2655             


Ser Glu  Ile Ile Gln Lys Gln  Val Val Met Lys His  Asn Ala Val 
    2660                 2665                 2670             


Ile Glu  His Leu Lys Gln Lys  Lys Ser Met Xaa Pro  Ala Glu Arg 
    2675                 2680                 2685             


Glu Glu  Asn Gln Arg Met Ile  Val Cys Asn Gln Val  Met Lys Tyr 
    2690                 2695                 2700             


Ile Leu  Asp Lys Ile Asp Lys  Glu Glu Lys Gln Ala  Ala Lys Lys 
    2705                 2710                 2715             


Arg Lys  Arg Glu Glu Ser Val  Glu Gln Lys Arg Ser  Lys Gln Asn 
    2720                 2725                 2730             


Ala Xaa  Lys Leu Ser Ala Leu  Leu Phe Lys His Lys  Glu Gln Leu 
    2735                 2740                 2745             


Arg Ala  Glu Ile Leu Lys Lys  Arg Ala Leu Leu Asp  Lys Asp Leu 
    2750                 2755                 2760             


Gln Ile  Glu Val Gln Glu Glu  Leu Lys Arg Asp Leu  Lys Ile Lys 
    2765                 2770                 2775             


Lys Glu  Lys Asp Leu Met Gln  Leu Ala Gln Ala Xaa  Ala Val Ala 
    2780                 2785                 2790             


Ala Pro  Cys Pro Pro Val Xaa  Pro Ala Pro Pro Ala  Pro Pro Ala 
    2795                 2800                 2805             


Pro Pro  Pro Ser Pro Pro Pro  Pro Pro Ala Val Gln  His Xaa Gly 
    2810                 2815                 2820             


Leu Leu  Ser Xaa Pro Xaa Leu  Pro Ala Ala Ser Gln  Lys Arg Lys 
    2825                 2830                 2835             


Arg Glu  Glu Glu Lys Asp Ser  Ser Ser Lys Ser Lys  Lys Lys Lys 
    2840                 2845                 2850             


Met Ile  Ser Xaa Xaa Ser Lys  Glu Xaa Lys Lys Asp  Xaa Lys Leu 
    2855                 2860                 2865             


Tyr Cys  Ile Cys Lys Xaa Pro  Tyr Asp Glu Ser Lys  Phe Tyr Ile 
    2870                 2875                 2880             


Gly Cys  Asp Arg Cys Gln Asn  Trp Tyr His Gly Arg  Cys Val Gly 
    2885                 2890                 2895             


Ile Leu  Gln Ser Glu Ala Glu  Leu Ile Asp Glu Tyr  Val Cys Pro 
    2900                 2905                 2910             


Gln Cys  Gln Ser Xaa Glu Asp  Ala Met Xaa Val Leu  Xaa Pro Leu 
    2915                 2920                 2925             


Xaa Glu  Lys Asp Tyr Glu Gly  Leu Lys Arg Val Leu  Arg Ser Leu 
    2930                 2935                 2940             


Gln Ala  His Lys Met Ala Trp  Pro Phe Leu Glu Pro  Val Asp Pro 
    2945                 2950                 2955             


Asn Asp  Ala Pro Asp Tyr Tyr  Gly Val Ile Lys Glu  Pro Met Asp 
    2960                 2965                 2970             


Leu Ala  Xaa Met Glu Glu Arg  Val Gln Arg Arg Tyr  Tyr Glu Lys 
    2975                 2980                 2985             


Leu Xaa  Glu Phe Val Ala Asp  Met Xaa Lys Ile Phe  Asp Asn Cys 
    2990                 2995                 3000             


Arg Tyr  Tyr Asn Pro Ser Asp  Ser Pro Phe Tyr Gln  Cys Ala Glu 
    3005                 3010                 3015             


Val Leu  Glu Ser Phe Phe Val  Gln Lys Leu Lys Gly  Phe Lys Ala 
    3020                 3025                 3030             


Ser Arg  Ser His Asn Asn Lys  Leu Gln Ser Xaa Ala  Ser 
    3035                 3040                 3045     


<210> 4333
<211> 810
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<400> 4333
Met Val Ser Glu Glu Glu Glu Glu Glu Asp Gly Asp Ala Glu Glu Xaa 
1               5                   10                  15      


Gln Asp Ser Glu Asp Asp Glu Glu Asp Glu Met Glu Glu Asp Asp Asp 
            20                  25                  30          


Asp Ser Asp Tyr Pro Glu Glu Met Glu Asp Asp Asp Asp Asp Ala Ser 
        35                  40                  45              


Tyr Cys Xaa Glu Ser Ser Phe Arg Ser His Ser Xaa Tyr Ser Ser Xaa 
    50                  55                  60                  


Pro Gly Arg Arg Lys Pro Arg Val His Arg Pro Arg Ser Pro Ile Leu 
65                  70                  75                  80  


Glu Glu Lys Asp Ile Pro Pro Leu Glu Phe Pro Lys Ser Ser Glu Asp 
                85                  90                  95      


Leu Met Val Pro Asn Glu His Ile Met Asn Val Ile Ala Ile Tyr Glu 
            100                 105                 110         


Val Leu Arg Asn Phe Gly Xaa Val Leu Arg Leu Ser Pro Phe Arg Phe 
        115                 120                 125             


Glu Asp Phe Cys Ala Ala Leu Val Ser Gln Glu Gln Cys Xaa Leu Met 
    130                 135                 140                 


Ala Glu Met His Val Val Leu Leu Lys Ala Val Leu Arg Glu Glu Asp 
145                 150                 155                 160 


Xaa Ser Asn Xaa Xaa Phe Gly Pro Ala Asp Leu Lys Asp Ser Val Asn 
                165                 170                 175     


Ser Xaa Leu Tyr Phe Ile Asp Gly Met Xaa Trp Pro Glu Val Leu Arg 
            180                 185                 190         


Val Tyr Cys Glu Ser Asp Lys Glu Tyr His His Val Leu Pro Tyr Gln 
        195                 200                 205             


Glu Ala Glu Asp Tyr Pro Tyr Gly Pro Val Glu Asn Lys Ile Lys Val 
    210                 215                 220                 


Leu Gln Phe Leu Val Asp Gln Phe Leu Xaa Xaa Asn Ile Ala Arg Glu 
225                 230                 235                 240 


Glu Leu Met Ser Glu Gly Val Ile Gln Tyr Asp Asp His Cys Arg Val 
                245                 250                 255     


Cys His Lys Leu Gly Asp Leu Leu Cys Cys Glu Xaa Cys Ser Ala Val 
            260                 265                 270         


Tyr His Leu Glu Cys Val Lys Pro Pro Leu Glu Glu Val Pro Glu Asp 
        275                 280                 285             


Glu Trp Gln Cys Glu Val Cys Val Ala His Lys Val Pro Gly Val Xaa 
    290                 295                 300                 


Asp Cys Val Ala Glu Ile Gln Lys Asn Lys Pro Tyr Ile Arg His Glu 
305                 310                 315                 320 


Pro Ile Gly Tyr Asp Arg Ser Arg Arg Lys Tyr Trp Phe Leu Asn Arg 
                325                 330                 335     


Arg Leu Ile Ile Glu Glu Asp Xaa Glu Asn Glu Asn Glu Lys Lys Ile 
            340                 345                 350         


Trp Tyr Tyr Ser Xaa Lys Val Gln Leu Ala Glu Leu Ile Asp Cys Leu 
        355                 360                 365             


Asp Lys Asp Tyr Trp Glu Ala Glu Leu Cys Lys Ile Leu Glu Glu Met 
    370                 375                 380                 


Arg Glu Glu Ile His Arg His Met Asp Ile Xaa Glu Asp Leu Xaa Asn 
385                 390                 395                 400 


Lys Ala Arg Gly Ser Asn Lys Ser Phe Leu Ala Ala Ala Asn Glu Glu 
                405                 410                 415     


Ile Leu Glu Ser Ile Arg Ala Lys Lys Gly Asp Ile Asp Asn Val Lys 
            420                 425                 430         


Ser Pro Glu Glu Xaa Glu Lys Asp Lys Asn Glu Xaa Glu Asn Asp Ser 
        435                 440                 445             


Lys Asp Ala Glu Lys Asn Arg Glu Glu Phe Glu Asp Gln Ser Leu Glu 
    450                 455                 460                 


Lys Asp Ser Asp Asp Lys Xaa Pro Asp Asp Asp Pro Glu Gln Gly Lys 
465                 470                 475                 480 


Ser Glu Glu Pro Xaa Glu Val Gly Asp Lys Gly Asn Ser Val Ser Ala 
                485                 490                 495     


Asn Leu Gly Asp Asn Xaa Xaa Asn Ala Xaa Ser Glu Glu Xaa Ser Pro 
            500                 505                 510         


Ser Glu Gly Arg Ser Pro Val Gly Cys Leu Ser Glu Xaa Pro Asp Ser 
        515                 520                 525             


Ser Asn Met Ala Glu Lys Lys Val Ala Ser Glu Leu Pro Gln Asp Val 
    530                 535                 540                 


Pro Glu Glu Pro Asn Lys Xaa Cys Glu Ser Ser Asn Xaa Ser Ala Xaa 
545                 550                 555                 560 


Xaa Xaa Ser Ile Gln Pro Asn Leu Glu Asn Ser Asn Ser Ser Ser Glu 
                565                 570                 575     


Leu Asn Ser Ser Gln Ser Glu Ser Ala Lys Ala Ala Asp Asp Pro Glu 
            580                 585                 590         


Asn Gly Glu Arg Glu Ser His Xaa Pro Val Ser Ile Gln Glu Glu Ile 
        595                 600                 605             


Val Gly Asp Phe Lys Ser Glu Lys Ser Asn Gly Glu Leu Ser Glu Ser 
    610                 615                 620                 


Pro Gly Ala Gly Lys Gly Ala Ser Gly Ser Xaa Arg Ile Ile Xaa Arg 
625                 630                 635                 640 


Leu Arg Asn Pro Asp Ser Lys Leu Ser Gln Leu Lys Ser Gln Gln Val 
                645                 650                 655     


Ala Ala Ala Ala His Glu Ala Asn Lys Leu Phe Lys Glu Gly Lys Glu 
            660                 665                 670         


Val Leu Val Val Asn Ser Gln Gly Glu Ile Ser Arg Leu Ser Xaa Lys 
        675                 680                 685             


Lys Glu Val Ile Met Lys Gly Asn Ile Asn Asn Tyr Phe Lys Leu Gly 
    690                 695                 700                 


Gln Glu Gly Lys Tyr Arg Val Tyr His Asn Gln Tyr Ser Xaa Asn Ser 
705                 710                 715                 720 


Phe Ala Leu Asn Lys His Gln His Arg Glu Asp His Asp Lys Arg Arg 
                725                 730                 735     


His Leu Ala His Lys Phe Cys Leu Xaa Pro Ala Gly Glu Phe Lys Trp 
            740                 745                 750         


Asn Gly Ser Val His Gly Ser Lys Val Leu Xaa Ile Ser Xaa Leu Arg 
        755                 760                 765             


Leu Xaa Ile Xaa Gln Leu Glu Xaa Xaa Ser Leu His Pro Phe Phe Ile 
    770                 775                 780                 


Pro Xaa Gly His His Ile Gly Gln Ile Gly Ser Arg Gln Phe Arg Cys 
785                 790                 795                 800 


Val Ala Asn Pro Glu Asn Leu His Trp Leu 
                805                 810 


<210> 4334
<211> 2764
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1083)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1195)..(1195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1248)..(1248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1282)..(1282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1308)..(1308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1391)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1443)..(1443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1470)..(1470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1490)..(1490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1494)..(1494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1500)..(1500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1502)..(1504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1525)..(1525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1532)..(1532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1537)..(1537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1570)..(1570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1576)..(1577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1579)..(1579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1581)..(1581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1584)..(1584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1588)..(1588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1599)..(1599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1604)..(1604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1611)..(1611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1613)..(1618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1620)..(1620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1624)..(1624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1627)..(1627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1642)..(1642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1645)..(1647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1649)..(1649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1653)..(1655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1658)..(1658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1661)..(1661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1664)..(1664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1671)..(1671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1686)..(1686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1690)..(1690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1700)..(1700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1749)..(1749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1753)..(1753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1793)..(1794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1796)..(1796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1798)..(1798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1801)..(1801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1804)..(1806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1837)..(1837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1841)..(1841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1843)..(1843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1861)..(1861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1865)..(1865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1872)..(1872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1913)..(1913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1917)..(1917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1919)..(1920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1923)..(1923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1926)..(1927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1929)..(1929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1946)..(1947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1949)..(1949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1954)..(1955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1962)..(1962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1964)..(1964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1974)..(1974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1977)..(1977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2003)..(2003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2005)..(2005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2009)..(2009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2011)..(2011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2017)..(2017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2019)..(2019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2021)..(2021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2026)..(2026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2032)..(2033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2040)..(2040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2049)..(2049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2053)..(2053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2059)..(2059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2067)..(2067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2081)..(2081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2091)..(2091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2098)..(2098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2102)..(2102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2109)..(2109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2112)..(2112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2114)..(2114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2135)..(2135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2140)..(2140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2143)..(2143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2153)..(2153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2162)..(2163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2174)..(2174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2192)..(2192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2199)..(2199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2203)..(2204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2206)..(2207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2210)..(2214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2217)..(2218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2222)..(2222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2241)..(2241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2259)..(2259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2270)..(2270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2282)..(2282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2288)..(2288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2290)..(2291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2303)..(2303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2336)..(2336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2342)..(2342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2356)..(2358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2368)..(2368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2402)..(2402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2453)..(2453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2508)..(2508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2518)..(2518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2540)..(2540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2545)..(2545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2547)..(2547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2575)..(2576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2580)..(2580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2584)..(2584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2592)..(2592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2636)..(2636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2641)..(2641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2644)..(2644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2647)..(2647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2694)..(2694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2708)..(2708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2715)..(2715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2762)..(2762)
<223> Selenocysteine

<400> 4334
Met Val Ser Glu Glu Glu Glu Glu Glu Asp Gly Asp Ala Glu Glu Xaa 
1               5                   10                  15      


Gln Asp Ser Glu Asp Asp Glu Glu Asp Glu Met Glu Glu Asp Asp Asp 
            20                  25                  30          


Asp Ser Asp Tyr Pro Glu Glu Met Glu Asp Asp Asp Asp Asp Ala Ser 
        35                  40                  45              


Tyr Cys Xaa Glu Ser Ser Phe Arg Ser His Ser Xaa Tyr Ser Ser Xaa 
    50                  55                  60                  


Pro Gly Arg Arg Lys Pro Arg Val His Arg Pro Arg Ser Pro Ile Leu 
65                  70                  75                  80  


Glu Glu Lys Asp Ile Pro Pro Leu Glu Phe Pro Lys Ser Ser Glu Asp 
                85                  90                  95      


Leu Met Val Pro Asn Glu His Ile Met Asn Val Ile Ala Ile Tyr Glu 
            100                 105                 110         


Val Leu Arg Asn Phe Gly Xaa Val Leu Arg Leu Ser Pro Phe Arg Phe 
        115                 120                 125             


Glu Asp Phe Cys Ala Ala Leu Val Ser Gln Glu Gln Cys Xaa Leu Met 
    130                 135                 140                 


Ala Glu Met His Val Val Leu Leu Lys Ala Val Leu Arg Glu Glu Asp 
145                 150                 155                 160 


Xaa Ser Asn Xaa Xaa Phe Gly Pro Ala Asp Leu Lys Asp Ser Val Asn 
                165                 170                 175     


Ser Xaa Leu Tyr Phe Ile Asp Gly Met Xaa Trp Pro Glu Val Leu Arg 
            180                 185                 190         


Val Tyr Cys Glu Ser Asp Lys Glu Tyr His His Val Leu Pro Tyr Gln 
        195                 200                 205             


Glu Ala Glu Asp Tyr Pro Tyr Gly Pro Val Glu Asn Lys Ile Lys Val 
    210                 215                 220                 


Leu Gln Phe Leu Val Asp Gln Phe Leu Xaa Xaa Asn Ile Ala Arg Glu 
225                 230                 235                 240 


Glu Leu Met Ser Glu Gly Val Ile Gln Tyr Asp Asp His Cys Arg Val 
                245                 250                 255     


Cys His Lys Leu Gly Asp Leu Leu Cys Cys Glu Xaa Cys Ser Ala Val 
            260                 265                 270         


Tyr His Leu Glu Cys Val Lys Pro Pro Leu Glu Glu Val Pro Glu Asp 
        275                 280                 285             


Glu Trp Gln Cys Glu Val Cys Val Ala His Lys Val Pro Gly Val Xaa 
    290                 295                 300                 


Asp Cys Val Ala Glu Ile Gln Lys Asn Lys Pro Tyr Ile Arg His Glu 
305                 310                 315                 320 


Pro Ile Gly Tyr Asp Arg Ser Arg Arg Lys Tyr Trp Phe Leu Asn Arg 
                325                 330                 335     


Arg Leu Ile Ile Glu Glu Asp Xaa Glu Asn Glu Asn Glu Lys Lys Ile 
            340                 345                 350         


Trp Tyr Tyr Ser Xaa Lys Val Gln Leu Ala Glu Leu Ile Asp Cys Leu 
        355                 360                 365             


Asp Lys Asp Tyr Trp Glu Ala Glu Leu Cys Lys Ile Leu Glu Glu Met 
    370                 375                 380                 


Arg Glu Glu Ile His Arg His Met Asp Ile Xaa Glu Asp Leu Xaa Asn 
385                 390                 395                 400 


Lys Ala Arg Gly Ser Asn Lys Ser Phe Leu Ala Ala Ala Asn Glu Glu 
                405                 410                 415     


Ile Leu Glu Ser Ile Arg Ala Lys Lys Gly Asp Ile Asp Asn Val Lys 
            420                 425                 430         


Ser Pro Glu Glu Xaa Glu Lys Asp Lys Asn Glu Xaa Glu Asn Asp Ser 
        435                 440                 445             


Lys Asp Ala Glu Lys Asn Arg Glu Glu Phe Glu Asp Gln Ser Leu Glu 
    450                 455                 460                 


Lys Asp Ser Asp Asp Lys Xaa Pro Asp Asp Asp Pro Glu Gln Gly Lys 
465                 470                 475                 480 


Ser Glu Glu Pro Xaa Glu Val Gly Asp Lys Gly Asn Ser Val Ser Ala 
                485                 490                 495     


Asn Leu Gly Asp Asn Xaa Xaa Asn Ala Xaa Ser Glu Glu Xaa Ser Pro 
            500                 505                 510         


Ser Glu Gly Arg Ser Pro Val Gly Cys Leu Ser Glu Xaa Pro Asp Ser 
        515                 520                 525             


Ser Asn Met Ala Glu Lys Lys Val Ala Ser Glu Leu Pro Gln Asp Val 
    530                 535                 540                 


Pro Glu Glu Pro Asn Lys Xaa Cys Glu Ser Ser Asn Xaa Ser Ala Xaa 
545                 550                 555                 560 


Xaa Xaa Ser Ile Gln Pro Asn Leu Glu Asn Ser Asn Ser Ser Ser Glu 
                565                 570                 575     


Leu Asn Ser Ser Gln Ser Glu Ser Ala Lys Ala Ala Asp Asp Pro Glu 
            580                 585                 590         


Asn Gly Glu Arg Glu Ser His Xaa Pro Val Ser Ile Gln Glu Glu Ile 
        595                 600                 605             


Val Gly Asp Phe Lys Ser Glu Lys Ser Asn Gly Glu Leu Ser Glu Ser 
    610                 615                 620                 


Pro Gly Ala Gly Lys Gly Ala Ser Gly Ser Xaa Arg Ile Ile Xaa Arg 
625                 630                 635                 640 


Leu Arg Asn Pro Asp Ser Lys Leu Ser Gln Leu Lys Ser Gln Gln Val 
                645                 650                 655     


Ala Ala Ala Ala His Glu Ala Asn Lys Leu Phe Lys Glu Gly Lys Glu 
            660                 665                 670         


Val Leu Val Val Asn Ser Gln Gly Glu Ile Ser Arg Leu Ser Xaa Lys 
        675                 680                 685             


Lys Glu Val Ile Met Lys Gly Asn Ile Asn Asn Tyr Phe Lys Leu Gly 
    690                 695                 700                 


Gln Glu Gly Lys Tyr Arg Val Tyr His Asn Gln Tyr Ser Xaa Asn Ser 
705                 710                 715                 720 


Phe Ala Leu Asn Lys His Gln His Arg Glu Asp His Asp Lys Arg Arg 
                725                 730                 735     


His Leu Ala His Lys Phe Cys Leu Xaa Pro Ala Gly Glu Phe Lys Trp 
            740                 745                 750         


Asn Gly Ser Val His Gly Ser Lys Val Leu Xaa Ile Ser Xaa Leu Arg 
        755                 760                 765             


Leu Xaa Ile Xaa Gln Leu Glu Asn Asn Ile Pro Ser Ser Phe Leu His 
    770                 775                 780                 


Pro Asn Trp Ala Ser His Arg Ala Asn Trp Ile Lys Ala Val Gln Met 
785                 790                 795                 800 


Cys Ser Lys Pro Arg Glu Phe Ala Leu Ala Leu Ala Ile Leu Glu Cys 
                805                 810                 815     


Ala Val Lys Pro Val Val Met Leu Pro Ile Trp Arg Glu Ser Leu Gly 
            820                 825                 830         


His Xaa Arg Leu His Arg Met Xaa Ser Ile Glu Arg Glu Glu Lys Glu 
        835                 840                 845             


Lys Val Lys Lys Lys Glu Lys Lys Gln Glu Glu Glu Glu Xaa Met Gln 
    850                 855                 860                 


Gln Ala Xaa Trp Val Lys Tyr Xaa Phe Pro Val Lys His Gln Val Trp 
865                 870                 875                 880 


Lys Gln Lys Gly Glu Glu Tyr Arg Val Xaa Gly Tyr Gly Gly Trp Ser 
                885                 890                 895     


Trp Ile Ser Lys Xaa His Val Tyr Arg Phe Val Pro Lys Leu Pro Gly 
            900                 905                 910         


Asn Xaa Asn Val Asn Tyr Arg Lys Ser Leu Glu Gly Xaa Lys Asn Asn 
        915                 920                 925             


Met Asp Glu Asn Met Asp Glu Ser Asp Lys Arg Lys Cys Ser Arg Ser 
    930                 935                 940                 


Pro Lys Lys Ile Lys Ile Glu Pro Asp Ser Glu Lys Asp Glu Val Lys 
945                 950                 955                 960 


Gly Ser Asp Ala Ala Lys Gly Ala Asp Gln Asn Glu Met Asp Ile Ser 
                965                 970                 975     


Lys Ile Xaa Glu Lys Lys Asp Gln Asp Val Lys Glu Leu Leu Asp Ser 
            980                 985                 990         


Asp Ser Asp Lys Pro Cys Lys Glu  Glu Pro Met Glu Val  Asp Asp Asp 
        995                 1000                 1005             


Met Lys  Xaa Glu Ser His Val  Asn Cys Gln Glu Ser  Ser Gln Val 
    1010                 1015                 1020             


Asp Val  Val Asn Val Ser Glu  Gly Phe His Leu Arg  Xaa Ser Tyr 
    1025                 1030                 1035             


Lys Lys  Lys Xaa Lys Ser Ser  Lys Leu Asp Gly Leu  Leu Glu Arg 
    1040                 1045                 1050             


Arg Ile  Lys Gln Phe Xaa Leu  Glu Glu Lys Gln Arg  Leu Glu Lys 
    1055                 1060                 1065             


Ile Lys  Leu Glu Gly Gly Ile  Lys Gly Ile Gly Lys  Xaa Ser Xaa 
    1070                 1075                 1080             


Asn Ser  Ser Lys Asn Leu Ser  Glu Ser Pro Val Ile  Xaa Lys Ala 
    1085                 1090                 1095             


Lys Glu  Gly Cys Gln Ser Asp  Ser Met Arg Gln Glu  Gln Ser Pro 
    1100                 1105                 1110             


Asn Ala  Asn Asn Asp Gln Pro  Glu Asp Leu Ile Gln  Gly Cys Ser 
    1115                 1120                 1125             


Glu Ser  Asp Ser Ser Val Leu  Arg Met Ser Asp Pro  Ser His Xaa 
    1130                 1135                 1140             


Xaa Asn  Lys Leu Tyr Pro Lys  Asp Arg Val Leu Asp  Asp Val Ser 
    1145                 1150                 1155             


Ile Arg  Ser Pro Glu Xaa Lys  Cys Pro Lys Gln Asn  Ser Ile Glu 
    1160                 1165                 1170             


Asn Asp  Ile Glu Glu Lys Val  Ser Asp Leu Ala Ser  Arg Gly Gln 
    1175                 1180                 1185             


Glu Pro  Ser Lys Ser Lys Xaa  Lys Gly Asn Asp Phe  Phe Ile Asp 
    1190                 1195                 1200             


Asp Ser  Lys Leu Ala Ser Ala  Asp Asp Ile Gly Xaa  Leu Ile Cys 
    1205                 1210                 1215             


Lys Asn  Lys Lys Pro Leu Ile  Gln Glu Glu Ser Asp  Xaa Ile Val 
    1220                 1225                 1230             


Ser Ser  Ser Lys Ser Ala Leu  His Ser Ser Val Pro  Lys Ser Xaa 
    1235                 1240                 1245             


Asn Asp  Arg Asp Ala Xaa Pro  Leu Ser Arg Ala Met  Asp Phe Glu 
    1250                 1255                 1260             


Gly Lys  Leu Gly Cys Asp Ser  Glu Ser Asn Ser Xaa  Leu Glu Asn 
    1265                 1270                 1275             


Ser Ser  Asp Xaa Val Ser Ile  Gln Asp Ser Ser Glu  Glu Asp Met 
    1280                 1285                 1290             


Ile Val  Gln Asn Ser Asn Glu  Ser Ile Ser Glu Gln  Phe Arg Xaa 
    1295                 1300                 1305             


Arg Glu  Gln Asp Val Glu Val  Leu Glu Pro Leu Lys  Cys Glu Leu 
    1310                 1315                 1320             


Val Ser  Gly Glu Ser Xaa Gly  Asn Cys Glu Asp Arg  Leu Pro Val 
    1325                 1330                 1335             


Lys Gly  Xaa Glu Ala Asn Gly  Lys Lys Pro Ser Gln  Gln Lys Lys 
    1340                 1345                 1350             


Leu Glu  Glu Arg Pro Val Asn  Lys Cys Ser Asp Gln  Ile Lys Leu 
    1355                 1360                 1365             


Lys Asn  Xaa Xaa Asp Lys Lys  Asn Asn Glu Asn Arg  Glu Ser Glu 
    1370                 1375                 1380             


Lys Lys  Gly Gln Arg Xaa Ser  Xaa Phe Gln Ile Asn  Gly Lys Asp 
    1385                 1390                 1395             


Asn Lys  Pro Lys Ile Tyr Leu  Lys Gly Glu Cys Leu  Lys Glu Ile 
    1400                 1405                 1410             


Ser Glu  Ser Arg Val Val Ser  Gly Asn Val Glu Pro  Lys Val Asn 
    1415                 1420                 1425             


Asn Ile  Asn Lys Ile Ile Pro  Glu Asn Asp Ile Lys  Ser Leu Xaa 
    1430                 1435                 1440             


Val Lys  Glu Ser Ala Ile Arg  Pro Phe Ile Asn Gly  Asp Val Ile 
    1445                 1450                 1455             


Met Glu  Asp Phe Asn Glu Arg  Asn Ser Ser Glu Xaa  Lys Ser His 
    1460                 1465                 1470             


Leu Leu  Ser Ser Ser Asp Ala  Glu Gly Asn Tyr Arg  Asp Ser Leu 
    1475                 1480                 1485             


Glu Xaa  Leu Pro Ser Xaa Lys  Glu Ser Asp Ser Xaa  Gln Xaa Xaa 
    1490                 1495                 1500             


Xaa Pro  Ser Ala Ser Cys Pro  Glu Ser Asn Ser Val  Asn Gln Val 
    1505                 1510                 1515             


Glu Asp  Met Glu Ile Glu Xaa  Ser Glu Val Lys Lys  Val Xaa Ser 
    1520                 1525                 1530             


Ser Pro  Ile Xaa Ser Glu Glu  Glu Ser Asn Leu Ser  Asn Asp Phe 
    1535                 1540                 1545             


Ile Asp  Glu Asn Gly Leu Pro  Ile Asn Lys Asn Glu  Asn Val Asn 
    1550                 1555                 1560             


Gly Glu  Ser Lys Arg Lys Xaa  Val Ile Xaa Glu Val  Xaa Xaa Met 
    1565                 1570                 1575             


Xaa Ser  Xaa Val Ala Xaa Glu  Ser Lys Xaa Val Ile  Lys Val Glu 
    1580                 1585                 1590             


Lys Gly  Asp Lys Gln Xaa Val  Val Ser Ser Xaa Glu  Asn Cys Ala 
    1595                 1600                 1605             


Lys Ser  Xaa Val Xaa Xaa Xaa  Xaa Xaa Xaa Val Xaa  Lys Leu Ser 
    1610                 1615                 1620             


Xaa Pro  Ser Xaa Gly Gly Ser  Val Asp Ile Ile Ser  Val Lys Glu 
    1625                 1630                 1635             


Gln Ser  Lys Xaa Val Val Xaa  Xaa Xaa Val Xaa Asp  Ser Leu Xaa 
    1640                 1645                 1650             


Xaa Xaa  Gly Gly Xaa Leu Val  Xaa Ser Met Xaa Val  Ser Lys Glu 
    1655                 1660                 1665             


Tyr Ser  Xaa Arg Asp Lys Val  Lys Leu Met Lys Phe  Ser Arg Pro 
    1670                 1675                 1680             


Lys Lys  Xaa Arg Ser Gly Xaa  Ala Leu Pro Ser Tyr  Arg Lys Phe 
    1685                 1690                 1695             


Val Xaa  Lys Ser Ser Lys Lys  Ser Ile Phe Val Leu  Pro Asn Asp 
    1700                 1705                 1710             


Asp Leu  Lys Lys Leu Ala Arg  Lys Gly Gly Ile Arg  Glu Val Pro 
    1715                 1720                 1725             


Tyr Phe  Asn Tyr Asn Ala Lys  Pro Ala Leu Asp Ile  Trp Pro Tyr 
    1730                 1735                 1740             


Pro Ser  Pro Arg Pro Xaa Phe  Gly Ile Xaa Trp Arg  Tyr Arg Leu 
    1745                 1750                 1755             


Gln Xaa  Val Lys Ser Leu Ala  Gly Val Ser Leu Met  Leu Arg Leu 
    1760                 1765                 1770             


Leu Trp  Ala Ser Leu Arg Trp  Asp Asp Met Ala Ala  Lys Ala Pro 
    1775                 1780                 1785             


Pro Gly  Gly Gly Xaa Xaa Arg  Xaa Glu Xaa Ser Glu  Xaa Glu Ile 
    1790                 1795                 1800             


Xaa Xaa  Xaa Glu Ile Ile Lys  Arg Arg Asp Val Gly  Pro Tyr Gly 
    1805                 1810                 1815             


Ile Arg  Ser Glu Tyr Cys Ile  Arg Lys Ile Ile Cys  Pro Ile Gly 
    1820                 1825                 1830             


Val Pro  Glu Xaa Pro Lys Glu  Xaa Pro Xaa Pro Gln  Arg Lys Gly 
    1835                 1840                 1845             


Leu Arg  Ser Ser Ala Leu Arg  Pro Lys Arg Pro Glu  Xaa Pro Lys 
    1850                 1855                 1860             


Gln Xaa  Gly Pro Val Ile Ile  Glu Xaa Trp Val Ala  Glu Glu Glu 
    1865                 1870                 1875             


Leu Glu  Leu Trp Glu Ile Arg  Ala Phe Ala Glu Arg  Val Glu Lys 
    1880                 1885                 1890             


Glu Lys  Ala Gln Ala Val Glu  Gln Gln Ala Lys Lys  Arg Leu Glu 
    1895                 1900                 1905             


Gln Gln  Lys Pro Xaa Val Ile  Ala Xaa Ser Xaa Xaa  Ser Pro Xaa 
    1910                 1915                 1920             


Ser Ser  Xaa Xaa Ser Xaa Ile  Ser Pro Ala Gln Lys  Val Met Val 
    1925                 1930                 1935             


Ala Pro  Ile Ser Gly Ser Val  Xaa Xaa Gly Xaa Lys  Met Val Leu 
    1940                 1945                 1950             


Xaa Xaa  Lys Val Gly Ser Pro  Ala Xaa Val Xaa Phe  Gln Gln Asn 
    1955                 1960                 1965             


Lys Asn  Phe His Gln Xaa Phe  Ala Xaa Trp Val Lys  Gln Gly Gln 
    1970                 1975                 1980             


Ser Asn  Ser Gly Val Val Gln  Val Gln Gln Lys Val  Leu Gly Ile 
    1985                 1990                 1995             


Ile Pro  Ser Ser Xaa Gly Xaa  Ser Gln Gln Xaa Phe  Xaa Ser Phe 
    2000                 2005                 2010             


Gln Pro  Arg Xaa Ala Xaa Val  Xaa Ile Arg Pro Asn  Xaa Ser Gly 
    2015                 2020                 2025             


Ser Gly  Gly Xaa Xaa Ser Asn  Ser Gln Val Ile Xaa  Gly Pro Gln 
    2030                 2035                 2040             


Ile Arg  Pro Gly Met Xaa Val  Ile Arg Xaa Pro Leu  Gln Gln Ser 
    2045                 2050                 2055             


Xaa Leu  Gly Lys Ala Ile Ile  Arg Xaa Pro Val Met  Val Gln Pro 
    2060                 2065                 2070             


Gly Ala  Pro Gln Gln Val Met  Xaa Gln Ile Ile Arg  Gly Gln Pro 
    2075                 2080                 2085             


Val Ser  Xaa Ala Val Ser Ala  Pro Asn Xaa Val Ser  Ser Xaa Pro 
    2090                 2095                 2100             


Gly Gln  Lys Ser Leu Xaa Ser  Ala Xaa Ser Xaa Ser  Asn Ile Gln 
    2105                 2110                 2115             


Ser Ser  Ala Ser Gln Pro Pro  Arg Pro Gln Gln Gly  Gln Val Lys 
    2120                 2125                 2130             


Leu Xaa  Met Ala Gln Leu Xaa  Gln Leu Xaa Gln Gly  His Gly Gly 
    2135                 2140                 2145             


Asn Gln  Gly Leu Xaa Val Val  Ile Gln Gly Gln Gly  Gln Xaa Xaa 
    2150                 2155                 2160             


Gly Gln  Leu Gln Leu Ile Pro  Gln Gly Val Xaa Val  Leu Pro Gly 
    2165                 2170                 2175             


Pro Gly  Gln Gln Leu Met Gln  Ala Ala Met Pro Asn  Gly Xaa Val 
    2180                 2185                 2190             


Gln Arg  Phe Leu Phe Xaa Pro  Leu Ala Xaa Xaa Ala  Xaa Xaa Ala 
    2195                 2200                 2205             


Ser Xaa  Xaa Xaa Xaa Xaa Val  Ser Xaa Xaa Ala Ala  Gly Xaa Gly 
    2210                 2215                 2220             


Glu Gln  Arg Gln Ser Lys Leu  Ser Pro Gln Met Gln  Val His Gln 
    2225                 2230                 2235             


Asp Lys  Xaa Leu Pro Pro Ala  Gln Ser Ser Ser Val  Gly Pro Ala 
    2240                 2245                 2250             


Glu Ala  Gln Pro Gln Xaa Ala  Gln Pro Ser Ala Gln  Pro Gln Pro 
    2255                 2260                 2265             


Gln Xaa  Gln Pro Gln Ser Pro  Ala Gln Pro Glu Val  Gln Xaa Gln 
    2270                 2275                 2280             


Pro Glu  Val Gln Xaa Gln Xaa  Xaa Val Ser Ser His  Val Pro Ser 
    2285                 2290                 2295             


Glu Ala  Gln Pro Xaa His Ala  Gln Ser Ser Lys Pro  Gln Val Ala 
    2300                 2305                 2310             


Ala Gln  Ser Gln Pro Gln Ser  Asn Val Gln Gly Gln  Ser Pro Val 
    2315                 2320                 2325             


Arg Val  Gln Ser Pro Ser Gln  Xaa Arg Ile Arg Pro  Ser Xaa Pro 
    2330                 2335                 2340             


Ser Gln  Leu Ser Pro Gly Gln  Gln Ser Gln Val Gln  Xaa Xaa Xaa 
    2345                 2350                 2355             


Ser Gln  Pro Ile Pro Ile Gln  Pro His Xaa Ser Leu  Gln Ile Pro 
    2360                 2365                 2370             


Ser Gln  Gly Gln Pro Gln Ser  Gln Pro Gln Val Val  Met Lys His 
    2375                 2380                 2385             


Asn Ala  Val Ile Glu His Leu  Lys Gln Lys Lys Ser  Met Xaa Pro 
    2390                 2395                 2400             


Ala Glu  Arg Glu Glu Asn Gln  Arg Met Ile Val Cys  Asn Gln Val 
    2405                 2410                 2415             


Met Lys  Tyr Ile Leu Asp Lys  Ile Asp Lys Glu Glu  Lys Gln Ala 
    2420                 2425                 2430             


Ala Lys  Lys Arg Lys Arg Glu  Glu Ser Val Glu Gln  Lys Arg Ser 
    2435                 2440                 2445             


Lys Gln  Asn Ala Xaa Lys Leu  Ser Ala Leu Leu Phe  Lys His Lys 
    2450                 2455                 2460             


Glu Gln  Leu Arg Ala Glu Ile  Leu Lys Lys Arg Ala  Leu Leu Asp 
    2465                 2470                 2475             


Lys Asp  Leu Gln Ile Glu Val  Gln Glu Glu Leu Lys  Arg Asp Leu 
    2480                 2485                 2490             


Lys Ile  Lys Lys Glu Lys Asp  Leu Met Gln Leu Ala  Gln Ala Xaa 
    2495                 2500                 2505             


Ala Val  Ala Ala Pro Cys Pro  Pro Val Xaa Pro Ala  Pro Pro Ala 
    2510                 2515                 2520             


Pro Pro  Ala Pro Pro Pro Ser  Pro Pro Pro Pro Pro  Ala Val Gln 
    2525                 2530                 2535             


His Xaa  Gly Leu Leu Ser Xaa  Pro Xaa Leu Pro Ala  Ala Ser Gln 
    2540                 2545                 2550             


Lys Arg  Lys Arg Glu Glu Glu  Lys Asp Ser Ser Ser  Lys Ser Lys 
    2555                 2560                 2565             


Lys Lys  Lys Met Ile Ser Xaa  Xaa Ser Lys Glu Xaa  Lys Lys Asp 
    2570                 2575                 2580             


Xaa Lys  Leu Tyr Cys Ile Cys  Lys Xaa Pro Tyr Asp  Glu Ser Lys 
    2585                 2590                 2595             


Phe Tyr  Ile Gly Cys Asp Arg  Cys Gln Asn Trp Tyr  His Gly Arg 
    2600                 2605                 2610             


Cys Val  Gly Ile Leu Gln Ser  Glu Ala Glu Leu Ile  Asp Glu Tyr 
    2615                 2620                 2625             


Val Cys  Pro Gln Cys Gln Ser  Xaa Glu Asp Ala Met  Xaa Val Leu 
    2630                 2635                 2640             


Xaa Pro  Leu Xaa Glu Lys Asp  Tyr Glu Gly Leu Lys  Arg Val Leu 
    2645                 2650                 2655             


Arg Ser  Leu Gln Ala His Lys  Met Ala Trp Pro Phe  Leu Glu Pro 
    2660                 2665                 2670             


Val Asp  Pro Asn Asp Ala Pro  Asp Tyr Tyr Gly Val  Ile Lys Glu 
    2675                 2680                 2685             


Pro Met  Asp Leu Ala Xaa Met  Glu Glu Arg Val Gln  Arg Arg Tyr 
    2690                 2695                 2700             


Tyr Glu  Lys Leu Xaa Glu Phe  Val Ala Asp Met Xaa  Lys Ile Phe 
    2705                 2710                 2715             


Asp Asn  Cys Arg Tyr Tyr Asn  Pro Ser Asp Ser Pro  Phe Tyr Gln 
    2720                 2725                 2730             


Cys Ala  Glu Val Leu Glu Ser  Phe Phe Val Gln Lys  Leu Lys Gly 
    2735                 2740                 2745             


Phe Lys  Ala Ser Arg Ser His  Asn Asn Lys Leu Gln  Ser Xaa Ala 
    2750                 2755                 2760             


Ser 
    


<210> 4335
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 4335
Xaa Asp Ala Glu Lys Asn Arg Glu Glu Phe Glu Asp Gln Ser Leu Glu 
1               5                   10                  15      


Lys Asp Ser Asp Asp Lys Xaa Pro Asp Asp Asp Pro Glu Gln Gly Lys 
            20                  25                  30          


Ser Glu Glu Glu Pro Asn Lys Xaa Cys Glu Ser Ser Asn Xaa Ser Ala 
        35                  40                  45              


Xaa Xaa Xaa Ser Ile Gln Pro Asn Leu Glu Asn Ser Asn Ser Ser Ser 
    50                  55                  60                  


Glu Leu Asn Ser Ser Gln Ser Glu Ser Ala Lys Ala Ala Asp Asp Pro 
65                  70                  75                  80  


Glu Asn Gly Glu Arg Glu Ser His Xaa Pro Val Ser Ile Gln Glu Glu 
                85                  90                  95      


Ile Val Gly Asp Phe Lys Ser Glu Lys Ser Asn Gly Glu Leu Ser Glu 
            100                 105                 110         


Ser Pro Gly Ala Gly Lys Gly Ala Ser Gly Ser Xaa Arg Ile Ile Xaa 
        115                 120                 125             


Arg Leu Arg Asn Pro Asp Ser Lys Leu 
    130                 135         


<210> 4336
<211> 420
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<400> 4336
Xaa His Leu Lys Gln Lys Lys Ser Met Xaa Pro Ala Glu Arg Glu Glu 
1               5                   10                  15      


Asn Gln Arg Met Ile Val Cys Asn Gln Val Met Lys Tyr Ile Leu Asp 
            20                  25                  30          


Lys Ile Asp Lys Glu Glu Lys Gln Ala Ala Lys Lys Arg Lys Arg Glu 
        35                  40                  45              


Glu Ser Val Glu Gln Lys Arg Ser Lys Gln Asn Ala Xaa Lys Leu Ser 
    50                  55                  60                  


Ala Leu Leu Phe Lys His Lys Glu Gln Leu Arg Ala Glu Ile Leu Lys 
65                  70                  75                  80  


Lys Arg Ala Leu Leu Asp Lys Asp Leu Gln Ile Glu Val Gln Glu Glu 
                85                  90                  95      


Leu Lys Arg Asp Leu Lys Ile Lys Lys Glu Lys Asp Leu Met Gln Leu 
            100                 105                 110         


Ala Gln Ala Xaa Ala Val Ala Ala Pro Cys Pro Pro Val Xaa Pro Ala 
        115                 120                 125             


Pro Pro Ala Pro Pro Ala Pro Pro Pro Ser Pro Pro Pro Pro Pro Ala 
    130                 135                 140                 


Val Gln His Xaa Gly Leu Leu Ser Xaa Pro Xaa Leu Pro Ala Ala Ser 
145                 150                 155                 160 


Gln Lys Arg Lys Arg Glu Glu Glu Lys Asp Ser Ser Ser Lys Ser Lys 
                165                 170                 175     


Lys Lys Lys Met Ile Ser Xaa Xaa Ser Lys Glu Xaa Lys Lys Asp Xaa 
            180                 185                 190         


Lys Leu Tyr Cys Ile Cys Lys Xaa Pro Tyr Asp Glu Ser Lys Phe Tyr 
        195                 200                 205             


Ile Gly Cys Asp Leu Cys Xaa Asn Trp Tyr His Gly Glu Cys Val Gly 
    210                 215                 220                 


Ile Xaa Glu Lys Glu Ala Lys Lys Met Asp Val Tyr Ile Cys Asn Asp 
225                 230                 235                 240 


Cys Lys Arg Ala Gln Glu Gly Ser Ser Glu Glu Leu Tyr Cys Ile Cys 
                245                 250                 255     


Arg Xaa Pro Tyr Asp Glu Ser Gln Phe Tyr Ile Gly Cys Asp Arg Cys 
            260                 265                 270         


Gln Asn Trp Tyr His Gly Arg Cys Val Gly Ile Leu Gln Ser Glu Ala 
        275                 280                 285             


Glu Leu Ile Asp Glu Tyr Val Cys Pro Gln Cys Gln Ser Xaa Glu Asp 
    290                 295                 300                 


Ala Met Xaa Val Leu Xaa Pro Leu Xaa Glu Lys Asp Tyr Glu Gly Leu 
305                 310                 315                 320 


Lys Arg Val Leu Arg Ser Leu Gln Ala His Lys Met Ala Trp Pro Phe 
                325                 330                 335     


Leu Glu Pro Val Asp Pro Asn Asp Ala Pro Asp Tyr Tyr Gly Val Ile 
            340                 345                 350         


Lys Glu Pro Met Asp Leu Ala Xaa Met Glu Glu Arg Val Gln Arg Arg 
        355                 360                 365             


Tyr Tyr Glu Lys Leu Xaa Glu Phe Val Ala Asp Met Xaa Lys Ile Phe 
    370                 375                 380                 


Asp Asn Cys Arg Tyr Tyr Asn Pro Ser Asp Ser Pro Phe Tyr Gln Cys 
385                 390                 395                 400 


Ala Glu Val Leu Glu Ser Phe Phe Val Gln Lys Leu Lys Gly Phe Lys 
                405                 410                 415     


Ala Ser Arg Leu 
            420 


<210> 4337
<211> 69
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<400> 4337
Xaa Leu Xaa Pro Leu Xaa Glu Lys Asp Tyr Glu Gly Leu Lys Arg Val 
1               5                   10                  15      


Leu Arg Ser Leu Gln Ala His Lys Met Ala Trp Pro Phe Leu Glu Pro 
            20                  25                  30          


Val Asp Pro Asn Asp Ala Pro Asp Tyr Tyr Gly Val Ile Lys Glu Pro 
        35                  40                  45              


Met Gly Leu Ile Xaa Xaa Asn Cys Ser Leu Gln Leu Leu Lys Val Gln 
    50                  55                  60                  


Arg Val Asn Leu Xaa 
65                  


<210> 4338
<211> 484
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<400> 4338
Xaa Asn Ile Gln Ser Ser Ala Ser Gln Pro Pro Arg Pro Gln Gln Gly 
1               5                   10                  15      


Gln Val Lys Leu Xaa Met Ala Gln Leu Xaa Gln Leu Xaa Gln Gly His 
            20                  25                  30          


Gly Gly Asn Gln Gly Leu Xaa Val Val Ile Gln Gly Gln Gly Gln Xaa 
        35                  40                  45              


Xaa Gly Gln Leu Gln Leu Ile Pro Gln Gly Val Xaa Val Leu Pro Gly 
    50                  55                  60                  


Pro Gly Gln Gln Leu Met Gln Ala Ala Met Pro Asn Gly Xaa Val Gln 
65                  70                  75                  80  


Arg Phe Leu Phe Xaa Pro Leu Ala Xaa Xaa Ala Xaa Xaa Ala Ser Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Val Ser Xaa Xaa Ala Ala Gly Xaa Gly Glu Gln Arg 
            100                 105                 110         


Gln Ser Lys Leu Ser Pro Gln Met Gln Val His Gln Asp Lys Xaa Leu 
        115                 120                 125             


Pro Pro Ala Gln Ser Ser Ser Val Gly Pro Ala Glu Ala Gln Pro Gln 
    130                 135                 140                 


Xaa Ala Gln Pro Ser Ala Gln Pro Gln Pro Gln Xaa Gln Pro Gln Ser 
145                 150                 155                 160 


Pro Ala Gln Pro Glu Val Gln Xaa Gln Pro Glu Val Gln Xaa Gln Xaa 
                165                 170                 175     


Xaa Val Ser Ser His Val Pro Ser Glu Ala Gln Pro Xaa His Ala Gln 
            180                 185                 190         


Ser Ser Lys Pro Gln Val Ala Ala Gln Ser Gln Pro Gln Ser Asn Val 
        195                 200                 205             


Gln Gly Gln Ser Pro Val Arg Val Gln Ser Pro Ser Gln Xaa Arg Ile 
    210                 215                 220                 


Arg Pro Ser Xaa Pro Ser Gln Leu Ser Pro Gly Gln Gln Ser Gln Val 
225                 230                 235                 240 


Gln Xaa Xaa Xaa Ser Gln Pro Ile Pro Ile Gln Pro His Xaa Ser Leu 
                245                 250                 255     


Gln Ile Pro Ser Gln Gly Gln Pro Gln Ser Gln Pro Gln Val Val Met 
            260                 265                 270         


Lys His Asn Ala Val Ile Glu His Leu Lys Gln Lys Lys Ser Met Xaa 
        275                 280                 285             


Pro Ala Glu Arg Glu Glu Asn Gln Arg Met Ile Val Cys Asn Gln Val 
    290                 295                 300                 


Met Lys Tyr Ile Leu Asp Lys Ile Asp Lys Glu Glu Lys Gln Ala Ala 
305                 310                 315                 320 


Lys Lys Arg Lys Arg Glu Glu Ser Val Glu Gln Lys Arg Ser Lys Gln 
                325                 330                 335     


Asn Ala Xaa Lys Leu Ser Ala Leu Leu Phe Lys His Lys Glu Gln Leu 
            340                 345                 350         


Arg Ala Glu Ile Leu Lys Lys Arg Ala Leu Leu Asp Lys Asp Leu Gln 
        355                 360                 365             


Ile Glu Val Gln Glu Glu Leu Lys Arg Asp Leu Lys Ile Lys Lys Glu 
    370                 375                 380                 


Lys Asp Leu Met Gln Leu Ala Gln Ala Xaa Ala Val Ala Ala Pro Cys 
385                 390                 395                 400 


Pro Pro Val Xaa Pro Ala Pro Pro Ala Pro Pro Ala Pro Pro Pro Ser 
                405                 410                 415     


Pro Pro Pro Pro Pro Ala Val Gln His Xaa Gly Leu Leu Ser Xaa Pro 
            420                 425                 430         


Xaa Leu Pro Ala Ala Ser Gln Lys Arg Lys Arg Glu Glu Glu Lys Asp 
        435                 440                 445             


Ser Ser Ser Lys Ser Lys Lys Lys Lys Met Ile Ser Xaa Xaa Ser Lys 
    450                 455                 460                 


Glu Xaa Lys Lys Asp Xaa Lys Leu Tyr Cys Ile Cys Lys Xaa Pro Tyr 
465                 470                 475                 480 


Asp Glu Ser Lys 
                


<210> 4339
<211> 339
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<400> 4339
Xaa Arg Lys Ile Ile Cys Pro Ile Gly Val Pro Glu Xaa Pro Lys Glu 
1               5                   10                  15      


Xaa Pro Xaa Pro Gln Arg Lys Gly Leu Arg Ser Ser Ala Leu Arg Pro 
            20                  25                  30          


Lys Arg Pro Glu Xaa Pro Lys Gln Xaa Gly Pro Val Ile Ile Glu Xaa 
        35                  40                  45              


Trp Val Ala Glu Glu Glu Leu Glu Leu Trp Glu Ile Arg Ala Phe Ala 
    50                  55                  60                  


Glu Arg Val Glu Lys Glu Lys Ala Gln Ala Val Glu Gln Gln Ala Lys 
65                  70                  75                  80  


Lys Arg Leu Glu Gln Gln Lys Pro Xaa Val Ile Ala Xaa Ser Xaa Xaa 
                85                  90                  95      


Ser Pro Xaa Ser Ser Xaa Xaa Ser Xaa Ile Ser Pro Ala Gln Lys Val 
            100                 105                 110         


Met Val Ala Pro Ile Ser Gly Ser Val Xaa Xaa Gly Xaa Lys Met Val 
        115                 120                 125             


Leu Xaa Xaa Lys Val Gly Ser Pro Ala Xaa Val Xaa Phe Gln Gln Asn 
    130                 135                 140                 


Lys Asn Phe His Gln Xaa Phe Ala Xaa Trp Val Lys Gln Gly Gln Ser 
145                 150                 155                 160 


Asn Ser Ala Xaa Ser Xaa Ala Ala Xaa Ser Ala Xaa Xaa Ile Ala Ser 
                165                 170                 175     


Xaa Gly Gln Xaa Phe Gln Ile Xaa Gly Asn Pro Val Xaa Met Ala Gly 
            180                 185                 190         


Lys Val Ile Xaa Lys Leu Pro Leu Pro Ala Asn Ser Lys Ile Val Ala 
        195                 200                 205             


Val Asn Val Pro Ala Xaa Gln Gly Gly Val Val Gln Val Gln Gln Lys 
    210                 215                 220                 


Val Leu Gly Ile Ile Pro Ser Ser Xaa Gly Xaa Ser Gln Gln Xaa Phe 
225                 230                 235                 240 


Xaa Ser Phe Gln Pro Arg Xaa Ala Xaa Val Xaa Ile Arg Pro Asn Xaa 
                245                 250                 255     


Ser Gly Ser Gly Gly Xaa Xaa Ser Asn Ser Gln Val Ile Xaa Gly Pro 
            260                 265                 270         


Gln Ile Arg Pro Gly Met Xaa Val Ile Arg Xaa Pro Leu Gln Gln Ser 
        275                 280                 285             


Xaa Leu Gly Lys Ala Ile Ile Arg Xaa Pro Val Met Val Gln Pro Gly 
    290                 295                 300                 


Ala Pro Gln Gln Val Met Xaa Gln Ile Ile Arg Gly Gln Pro Val Ser 
305                 310                 315                 320 


Xaa Ala Val Ser Ala Pro Asn Xaa Val Ser Ser Xaa Pro Gly Gln Lys 
                325                 330                 335     


Ser Leu Xaa 
            


<210> 4340
<211> 64
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<400> 4340
Xaa Arg Tyr Tyr Glu Lys Leu Xaa Glu Phe Val Ala Asp Met Xaa Lys 
1               5                   10                  15      


Ile Phe Asp Asn Cys Arg Tyr Tyr Asn Pro Ser Asp Ser Pro Phe Tyr 
            20                  25                  30          


Gln Cys Ala Glu Val Leu Glu Ser Phe Phe Val Gln Lys Leu Lys Gly 
        35                  40                  45              


Phe Lys Ala Ser Arg Val Asn Glu Arg Xaa Trp Leu Leu Leu Pro Asp 
    50                  55                  60                  


<210> 4341
<211> 650
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<400> 4341
Xaa Xaa Val Leu Pro Gly Pro Gly Gln Gln Leu Met Gln Ala Ala Met 
1               5                   10                  15      


Pro Asn Gly Xaa Val Gln Arg Phe Leu Phe Xaa Pro Leu Ala Xaa Xaa 
            20                  25                  30          


Ala Xaa Xaa Ala Ser Xaa Xaa Xaa Xaa Xaa Val Ser Xaa Xaa Ala Ala 
        35                  40                  45              


Gly Xaa Gly Glu Gln Arg Gln Ser Lys Leu Ser Pro Gln Met Gln Val 
    50                  55                  60                  


His Gln Asp Lys Xaa Leu Pro Pro Ala Gln Ser Ser Ser Val Gly Pro 
65                  70                  75                  80  


Ala Glu Ala Gln Pro Gln Xaa Ala Gln Pro Ser Ala Gln Pro Gln Pro 
                85                  90                  95      


Gln Xaa Gln Pro Gln Ser Pro Ala Gln Pro Glu Val Gln Xaa Gln Pro 
            100                 105                 110         


Glu Val Gln Xaa Gln Xaa Xaa Val Ser Ser His Val Pro Ser Glu Ala 
        115                 120                 125             


Gln Pro Xaa His Ala Gln Ser Ser Lys Pro Gln Val Ala Ala Gln Ser 
    130                 135                 140                 


Gln Pro Gln Ser Asn Val Gln Gly Gln Ser Pro Val Arg Val Gln Ser 
145                 150                 155                 160 


Pro Ser Gln Xaa Arg Ile Arg Pro Ser Xaa Pro Ser Gln Leu Ser Pro 
                165                 170                 175     


Gly Gln Gln Ser Gln Val Gln Xaa Xaa Xaa Ser Gln Pro Ile Pro Ile 
            180                 185                 190         


Gln Pro His Xaa Ser Leu Gln Ile Pro Ser Gln Gly Gln Pro Gln Ser 
        195                 200                 205             


Gln Pro Gln Val Val Met Lys His Asn Ala Val Ile Glu His Leu Lys 
    210                 215                 220                 


Gln Lys Lys Ser Met Xaa Pro Ala Glu Arg Glu Glu Asn Gln Arg Met 
225                 230                 235                 240 


Ile Val Cys Asn Gln Val Met Lys Tyr Ile Leu Asp Lys Ile Asp Lys 
                245                 250                 255     


Glu Glu Lys Gln Ala Ala Lys Lys Arg Lys Arg Glu Glu Ser Val Glu 
            260                 265                 270         


Gln Lys Arg Ser Lys Gln Asn Ala Xaa Lys Leu Ser Ala Leu Leu Phe 
        275                 280                 285             


Lys His Lys Glu Gln Leu Arg Ala Glu Ile Leu Lys Lys Arg Ala Leu 
    290                 295                 300                 


Leu Asp Lys Asp Leu Gln Ile Glu Val Gln Glu Glu Leu Lys Arg Asp 
305                 310                 315                 320 


Leu Lys Ile Lys Lys Glu Lys Asp Leu Met Gln Leu Ala Gln Ala Xaa 
                325                 330                 335     


Ala Val Ala Ala Pro Cys Pro Pro Val Xaa Pro Ala Pro Pro Ala Pro 
            340                 345                 350         


Pro Ala Pro Pro Pro Ser Pro Pro Pro Pro Pro Ala Val Gln His Xaa 
        355                 360                 365             


Gly Leu Leu Ser Xaa Pro Xaa Leu Pro Ala Ala Ser Gln Lys Arg Lys 
    370                 375                 380                 


Arg Glu Glu Glu Lys Asp Ser Ser Ser Lys Ser Lys Lys Lys Lys Met 
385                 390                 395                 400 


Ile Ser Xaa Xaa Ser Lys Glu Xaa Lys Lys Asp Xaa Lys Leu Tyr Cys 
                405                 410                 415     


Ile Cys Lys Xaa Pro Tyr Asp Glu Ser Lys Phe Tyr Ile Gly Cys Asp 
            420                 425                 430         


Leu Cys Xaa Asn Trp Tyr His Gly Glu Cys Val Gly Ile Xaa Glu Lys 
        435                 440                 445             


Glu Ala Lys Lys Met Asp Val Tyr Ile Cys Asn Asp Cys Lys Arg Ala 
    450                 455                 460                 


Gln Glu Gly Ser Ser Glu Glu Leu Tyr Cys Ile Cys Arg Xaa Pro Tyr 
465                 470                 475                 480 


Asp Glu Ser Gln Phe Tyr Ile Gly Cys Asp Arg Cys Gln Asn Trp Tyr 
                485                 490                 495     


His Gly Arg Cys Val Gly Ile Leu Gln Ser Glu Ala Glu Leu Ile Asp 
            500                 505                 510         


Glu Tyr Val Cys Pro Gln Cys Gln Ser Xaa Glu Asp Ala Met Xaa Val 
        515                 520                 525             


Leu Xaa Pro Leu Xaa Glu Lys Asp Tyr Glu Gly Leu Lys Arg Val Leu 
    530                 535                 540                 


Arg Ser Leu Gln Ala His Lys Met Ala Trp Pro Phe Leu Glu Pro Val 
545                 550                 555                 560 


Asp Pro Asn Asp Ala Pro Asp Tyr Tyr Gly Val Ile Lys Glu Pro Met 
                565                 570                 575     


Asp Leu Ala Xaa Met Glu Glu Arg Val Gln Arg Arg Tyr Tyr Glu Lys 
            580                 585                 590         


Leu Xaa Glu Phe Val Ala Asp Met Xaa Lys Ile Phe Asp Asn Cys Arg 
        595                 600                 605             


Tyr Tyr Asn Pro Ser Asp Ser Pro Phe Tyr Gln Cys Ala Glu Val Leu 
    610                 615                 620                 


Glu Ser Phe Phe Val Gln Lys Leu Lys Gly Phe Lys Ala Ser Arg Ser 
625                 630                 635                 640 


His Asn Asn Lys Leu Gln Ser Xaa Ala Ser 
                645                 650 


<210> 4342
<211> 102
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<400> 4342
Ile His Arg Asp Leu Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu 
1               5                   10                  15      


Xaa Val Lys Ile Gly Asp Phe Gly Leu Ala Xaa Val Lys Ser Arg Trp 
            20                  25                  30          


Ser Gly Ser His Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met 
        35                  40                  45              


Ala Pro Glu Val Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln 
    50                  55                  60                  


Ser Asp Val Tyr Ala Phe Gly Ile Val Leu Tyr Glu Leu Met Xaa Gly 
65                  70                  75                  80  


Gln Leu Pro Tyr Ser Asn Ile Asn Asn Arg Asp Gln Val Leu Cys Pro 
                85                  90                  95      


Pro Trp Glu Tyr Asn Lys 
            100         


<210> 4343
<211> 766
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<400> 4343
Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln 
1               5                   10                  15      


Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Ala Gly 
            20                  25                  30          


Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp 
        35                  40                  45              


Asn Ile Lys Gln Met Ile Lys Leu Xaa Gln Glu His Ile Glu Ala Leu 
    50                  55                  60                  


Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu 
65                  70                  75                  80  


Ala Tyr Glu Glu Tyr Xaa Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu 
                85                  90                  95      


Gln Gln Leu Leu Glu Ser Leu Gly Asn Gly Xaa Asp Phe Ser Val Ser 
            100                 105                 110         


Ser Ser Ala Ser Met Asp Xaa Val Xaa Ser Ser Ser Ser Ser Ser Leu 
        115                 120                 125             


Ser Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Xaa Asp Val 
    130                 135                 140                 


Ala Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe 
145                 150                 155                 160 


Leu Pro Asn Lys Gln Arg Xaa Val Val Pro Ala Arg Cys Gly Val Xaa 
                165                 170                 175     


Val Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro 
            180                 185                 190         


Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile 
        195                 200                 205             


Gly Trp Asp Xaa Asp Ile Ser Trp Leu Xaa Gly Glu Glu Leu His Val 
    210                 215                 220                 


Glu Val Leu Glu Asn Val Pro Leu Xaa Xaa His Asn Phe Val Arg Lys 
225                 230                 235                 240 


Xaa Phe Phe Xaa Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe 
                245                 250                 255     


Gln Gly Phe Arg Cys Gln Xaa Cys Gly Tyr Lys Phe His Gln Arg Cys 
            260                 265                 270         


Ser Xaa Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu 
        275                 280                 285             


Leu Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu 
    290                 295                 300                 


Ala Ser Leu Ala Glu Xaa Ala Leu Xaa Ser Gly Ser Ser Pro Ser Ala 
305                 310                 315                 320 


Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Xaa Ser Pro Ser Pro 
                325                 330                 335     


Ser Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp 
            340                 345                 350         


His Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn 
        355                 360                 365             


Val His Ile Asn Xaa Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg 
    370                 375                 380                 


Asp Gln Gly Phe Arg Gly Asp Gly Gly Ser Xaa Xaa Gly Leu Ser Ala 
385                 390                 395                 400 


Xaa Pro Pro Ala Ser Leu Pro Gly Ser Leu Xaa Asn Val Lys Ala Leu 
                405                 410                 415     


Gln Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser 
            420                 425                 430         


Glu Asp Arg Asn Arg Met Lys Xaa Leu Gly Arg Arg Asp Ser Ser Asp 
        435                 440                 445             


Asp Trp Glu Ile Pro Asp Gly Gln Ile Xaa Val Gly Gln Arg Ile Gly 
    450                 455                 460                 


Ser Gly Ser Phe Gly Xaa Val Tyr Lys Gly Lys Trp His Gly Asp Val 
465                 470                 475                 480 


Ala Val Lys Met Leu Asn Val Xaa Ala Pro Xaa Pro Gln Gln Leu Gln 
                485                 490                 495     


Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Xaa Arg His Val Asn 
            500                 505                 510         


Ile Leu Leu Phe Met Gly Tyr Ser Xaa Lys Pro Gln Leu Ala Ile Val 
        515                 520                 525             


Xaa Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile 
    530                 535                 540                 


Glu Xaa Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Xaa 
545                 550                 555                 560 


Ala Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp 
                565                 570                 575     


Leu Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Xaa Val Lys Ile 
            580                 585                 590         


Gly Asp Phe Gly Leu Ala Xaa Val Lys Ser Arg Trp Ser Gly Ser His 
        595                 600                 605             


Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val 
    610                 615                 620                 


Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr 
625                 630                 635                 640 


Ala Phe Gly Ile Val Leu Tyr Glu Leu Met Xaa Gly Gln Leu Pro Tyr 
                645                 650                 655     


Ser Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly 
            660                 665                 670         


Tyr Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala 
        675                 680                 685             


Met Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg 
    690                 695                 700                 


Pro Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser 
705                 710                 715                 720 


Leu Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala 
                725                 730                 735     


Gly Phe Gln Xaa Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys 
            740                 745                 750         


Xaa Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His 
        755                 760                 765     


<210> 4344
<211> 194
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<400> 4344
Gln Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Ala 
1               5                   10                  15      


Gly Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val 
            20                  25                  30          


Trp Asn Ile Lys Gln Met Ile Lys Leu Xaa Gln Glu His Ile Glu Ala 
        35                  40                  45              


Leu Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu 
    50                  55                  60                  


Glu Ala Tyr Glu Glu Tyr Xaa Ser Lys Leu Asp Ala Leu Gln Gln Arg 
65                  70                  75                  80  


Glu Gln Gln Leu Leu Glu Ser Leu Gly Asn Gly Xaa Asp Phe Ser Val 
                85                  90                  95      


Ser Ser Ser Ala Ser Met Asp Xaa Val Xaa Ser Ser Ser Ser Ser Ser 
            100                 105                 110         


Leu Ser Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Xaa Asp 
        115                 120                 125             


Val Ala Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val 
    130                 135                 140                 


Phe Leu Pro Asn Lys Gln Arg Xaa Val Val Pro Ala Arg Cys Gly Val 
145                 150                 155                 160 


Xaa Val Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile 
                165                 170                 175     


Pro Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Ser Phe Leu Glu 
            180                 185                 190         


Leu Xaa 
        


<210> 4345
<211> 375
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<400> 4345
Xaa Ser Xaa Xaa Gly Leu Ser Ala Xaa Pro Pro Ala Ser Leu Pro Gly 
1               5                   10                  15      


Ser Leu Xaa Asn Val Lys Ala Leu Gln Lys Ser Pro Gly Pro Gln Arg 
            20                  25                  30          


Glu Arg Lys Ser Ser Ser Ser Ser Glu Asp Arg Asn Arg Met Lys Xaa 
        35                  40                  45              


Leu Gly Arg Arg Asp Ser Ser Asp Asp Trp Glu Ile Pro Asp Gly Gln 
    50                  55                  60                  


Ile Xaa Val Gly Gln Arg Ile Gly Ser Gly Ser Phe Gly Xaa Val Tyr 
65                  70                  75                  80  


Lys Gly Lys Trp His Gly Asp Val Ala Val Lys Met Leu Asn Val Xaa 
                85                  90                  95      


Ala Pro Xaa Pro Gln Gln Leu Gln Ala Phe Lys Asn Glu Val Gly Val 
            100                 105                 110         


Leu Arg Lys Xaa Arg His Val Asn Ile Leu Leu Phe Met Gly Tyr Ser 
        115                 120                 125             


Xaa Lys Pro Gln Leu Ala Ile Val Xaa Gln Trp Cys Glu Gly Ser Ser 
    130                 135                 140                 


Leu Tyr His His Leu His Ile Ile Glu Xaa Lys Phe Glu Met Ile Lys 
145                 150                 155                 160 


Leu Ile Asp Ile Ala Arg Gln Xaa Ala Gln Gly Met Asp Tyr Leu His 
                165                 170                 175     


Ala Lys Ser Ile Ile His Arg Asp Leu Lys Ser Asn Asn Ile Phe Leu 
            180                 185                 190         


His Glu Asp Leu Xaa Val Lys Ile Gly Asp Phe Gly Leu Ala Xaa Val 
        195                 200                 205             


Lys Ser Arg Trp Ser Gly Ser His Gln Phe Glu Gln Leu Ser Gly Ser 
    210                 215                 220                 


Ile Leu Trp Met Ala Pro Glu Val Ile Arg Met Gln Asp Lys Asn Pro 
225                 230                 235                 240 


Tyr Ser Phe Gln Ser Asp Val Tyr Ala Phe Gly Ile Val Leu Tyr Glu 
                245                 250                 255     


Leu Met Xaa Gly Gln Leu Pro Tyr Ser Asn Ile Asn Asn Arg Asp Gln 
            260                 265                 270         


Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser Pro Asp Leu Ser Lys 
        275                 280                 285             


Val Arg Ser Asn Cys Pro Lys Ala Met Lys Arg Leu Met Ala Glu Cys 
    290                 295                 300                 


Leu Lys Lys Lys Arg Asp Glu Arg Pro Leu Phe Pro Gln Ile Leu Ala 
305                 310                 315                 320 


Ser Ile Glu Leu Leu Ala Arg Ser Leu Pro Lys Ile His Arg Ser Ala 
                325                 330                 335     


Ser Glu Pro Ser Leu Asn Arg Ala Gly Phe Gln Xaa Glu Asp Phe Ser 
            340                 345                 350         


Leu Tyr Ala Cys Ala Ser Pro Lys Xaa Pro Ile Gln Ala Gly Gly Tyr 
        355                 360                 365             


Gly Glu Phe Ala Ala Phe Lys 
    370                 375 


<210> 4346
<211> 562
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<400> 4346
Met Ser Asp Glu Glu Ile Lys Lys Xaa Xaa Leu Ala Ser Ala Val Ala 
1               5                   10                  15      


Cys Leu Glu Gly Lys Ser Pro Gly Glu Lys Val Ala Ile Ile His Gln 
            20                  25                  30          


His Leu Gly Arg Arg Glu Met Xaa Asp Val Ile Ile Glu Xaa Met Lys 
        35                  40                  45              


Ser Asn Pro Asp Glu Leu Lys Xaa Xaa Val Glu Glu Arg Lys Ser Ser 
    50                  55                  60                  


Glu Ala Ser Pro Xaa Ala Gln Arg Ser Lys Asp His Ser Lys Glu Cys 
65                  70                  75                  80  


Ile Asn Ala Ala Pro Asp Ser Pro Ser Lys Gln Leu Pro Asp Gln Ile 
                85                  90                  95      


Ser Phe Phe Ser Gly Asn Pro Ser Val Glu Ile Val His Gly Ile Met 
            100                 105                 110         


His Leu Tyr Lys Xaa Asn Lys Met Xaa Ser Leu Lys Glu Asp Val Arg 
        115                 120                 125             


Arg Ser Ala Met Leu Cys Ile Leu Xaa Val Pro Ala Ala Met Xaa Ser 
    130                 135                 140                 


His Asp Leu Met Lys Phe Val Ala Pro Phe Asn Glu Val Ile Glu Gln 
145                 150                 155                 160 


Met Lys Ile Ile Arg Asp Ser Xaa Pro Asn Gln Tyr Met Val Leu Ile 
                165                 170                 175     


Lys Phe Arg Ala Gln Ala Asp Ala Asp Ser Phe Tyr Met Xaa Cys Asn 
            180                 185                 190         


Gly Arg Gln Phe Asn Ser Ile Glu Asp Asp Val Cys Gln Leu Val Tyr 
        195                 200                 205             


Val Glu Arg Ala Glu Val Leu Lys Ser Glu Asp Gly Ala Ser Leu Pro 
    210                 215                 220                 


Val Met Asp Leu Xaa Glu Leu Pro Lys Cys Xaa Val Cys Leu Glu Arg 
225                 230                 235                 240 


Met Asp Glu Ser Val Asn Gly Ile Leu Xaa Xaa Leu Cys Asn His Ser 
                245                 250                 255     


Phe His Ser Gln Cys Leu Gln Arg Trp Asp Asp Xaa Xaa Cys Pro Val 
            260                 265                 270         


Cys Arg Tyr Cys Gln Xaa Pro Glu Pro Val Glu Glu Asn Lys Cys Phe 
        275                 280                 285             


Glu Cys Gly Val Gln Glu Asn Leu Trp Ile Cys Leu Ile Cys Gly His 
    290                 295                 300                 


Ile Gly Cys Gly Arg Tyr Val Ser Arg His Ala Tyr Lys His Phe Glu 
305                 310                 315                 320 


Glu Xaa Gln His Xaa Tyr Ala Met Gln Leu Xaa Asn His Arg Val Trp 
                325                 330                 335     


Asp Tyr Ala Gly Asp Asn Tyr Val His Arg Leu Val Ala Ser Lys Xaa 
            340                 345                 350         


Asp Gly Lys Ile Val Gln Tyr Glu Cys Glu Gly Asp Xaa Cys Gln Glu 
        355                 360                 365             


Glu Lys Ile Asp Ala Leu Gln Leu Glu Tyr Ser Tyr Leu Leu Xaa Ser 
    370                 375                 380                 


Gln Leu Glu Ser Gln Arg Ile Tyr Trp Glu Asn Lys Ile Val Arg Ile 
385                 390                 395                 400 


Glu Lys Asp Xaa Ala Glu Glu Ile Asn Asn Met Lys Xaa Lys Phe Lys 
                405                 410                 415     


Glu Xaa Ile Glu Lys Cys Asp Asn Leu Glu His Lys Leu Asn Asp Leu 
            420                 425                 430         


Leu Lys Glu Lys Gln Ser Val Glu Arg Lys Cys Xaa Gln Leu Asn Xaa 
        435                 440                 445             


Lys Val Ala Lys Leu Xaa Asn Glu Leu Lys Glu Glu Gln Glu Met Asn 
    450                 455                 460                 


Lys Cys Leu Arg Ala Asn Gln Val Leu Leu Gln Asn Lys Leu Lys Glu 
465                 470                 475                 480 


Glu Glu Arg Val Leu Lys Glu Xaa Cys Asp Gln Lys Asp Leu Gln Ile 
                485                 490                 495     


Xaa Glu Ile Gln Glu Gln Leu Arg Asp Val Met Phe Tyr Leu Glu Xaa 
            500                 505                 510         


Gln Gln Lys Ile Asn His Leu Pro Ala Glu Xaa Arg Gln Glu Ile Gln 
        515                 520                 525             


Glu Gly Gln Ile Asn Ile Ala Met Ala Ser Ala Ser Ser Pro Ala Ser 
    530                 535                 540                 


Ser Gly Gly Ser Gly Lys Leu Pro Ser Arg Lys Gly Arg Ser Lys Arg 
545                 550                 555                 560 


Gly Lys 
        


<210> 4347
<211> 592
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<400> 4347
Met Ser Val Ser Leu Val Val Ile Arg Leu Glu Leu Ala Glu His Ser 
1               5                   10                  15      


Pro Val Pro Ala Gly Phe Gly Phe Ser Ala Ala Ala Gly Glu Met Ser 
            20                  25                  30          


Asp Glu Glu Ile Lys Lys Xaa Xaa Leu Ala Ser Ala Val Ala Cys Leu 
        35                  40                  45              


Glu Gly Lys Ser Pro Gly Glu Lys Val Ala Ile Ile His Gln His Leu 
    50                  55                  60                  


Gly Arg Arg Glu Met Xaa Asp Val Ile Ile Glu Xaa Met Lys Ser Asn 
65                  70                  75                  80  


Pro Asp Glu Leu Lys Xaa Xaa Val Glu Glu Arg Lys Ser Ser Glu Ala 
                85                  90                  95      


Ser Pro Xaa Ala Gln Arg Ser Lys Asp His Ser Lys Glu Cys Ile Asn 
            100                 105                 110         


Ala Ala Pro Asp Ser Pro Ser Lys Gln Leu Pro Asp Gln Ile Ser Phe 
        115                 120                 125             


Phe Ser Gly Asn Pro Ser Val Glu Ile Val His Gly Ile Met His Leu 
    130                 135                 140                 


Tyr Lys Xaa Asn Lys Met Xaa Ser Leu Lys Glu Asp Val Arg Arg Ser 
145                 150                 155                 160 


Ala Met Leu Cys Ile Leu Xaa Val Pro Ala Ala Met Xaa Ser His Asp 
                165                 170                 175     


Leu Met Lys Phe Val Ala Pro Phe Asn Glu Val Ile Glu Gln Met Lys 
            180                 185                 190         


Ile Ile Arg Asp Ser Xaa Pro Asn Gln Tyr Met Val Leu Ile Lys Phe 
        195                 200                 205             


Arg Ala Gln Ala Asp Ala Asp Ser Phe Tyr Met Xaa Cys Asn Gly Arg 
    210                 215                 220                 


Gln Phe Asn Ser Ile Glu Asp Asp Val Cys Gln Leu Val Tyr Val Glu 
225                 230                 235                 240 


Arg Ala Glu Val Leu Lys Ser Glu Asp Gly Ala Ser Leu Pro Val Met 
                245                 250                 255     


Asp Leu Xaa Glu Leu Pro Lys Cys Xaa Val Cys Leu Glu Arg Met Asp 
            260                 265                 270         


Glu Ser Val Asn Gly Ile Leu Xaa Xaa Leu Cys Asn His Ser Phe His 
        275                 280                 285             


Ser Gln Cys Leu Gln Arg Trp Asp Asp Xaa Xaa Cys Pro Val Cys Arg 
    290                 295                 300                 


Tyr Cys Gln Xaa Pro Glu Pro Val Glu Glu Asn Lys Cys Phe Glu Cys 
305                 310                 315                 320 


Gly Val Gln Glu Asn Leu Trp Ile Cys Leu Ile Cys Gly His Ile Gly 
                325                 330                 335     


Cys Gly Arg Tyr Val Ser Arg His Ala Tyr Lys His Phe Glu Glu Xaa 
            340                 345                 350         


Gln His Xaa Tyr Ala Met Gln Leu Xaa Asn His Arg Val Trp Asp Tyr 
        355                 360                 365             


Ala Gly Asp Asn Tyr Val His Arg Leu Val Ala Ser Lys Xaa Asp Gly 
    370                 375                 380                 


Lys Ile Val Gln Tyr Glu Cys Glu Gly Asp Xaa Cys Gln Glu Glu Lys 
385                 390                 395                 400 


Ile Asp Ala Leu Gln Leu Glu Tyr Ser Tyr Leu Leu Xaa Ser Gln Leu 
                405                 410                 415     


Glu Ser Gln Arg Ile Tyr Trp Glu Asn Lys Ile Val Arg Ile Glu Lys 
            420                 425                 430         


Asp Xaa Ala Glu Glu Ile Asn Asn Met Lys Xaa Lys Phe Lys Glu Xaa 
        435                 440                 445             


Ile Glu Lys Cys Asp Asn Leu Glu His Lys Leu Asn Asp Leu Leu Lys 
    450                 455                 460                 


Glu Lys Gln Ser Val Glu Arg Lys Cys Xaa Gln Leu Asn Xaa Lys Val 
465                 470                 475                 480 


Ala Lys Leu Xaa Asn Glu Leu Lys Glu Glu Gln Glu Met Asn Lys Cys 
                485                 490                 495     


Leu Arg Ala Asn Gln Val Leu Leu Gln Asn Lys Leu Lys Glu Glu Glu 
            500                 505                 510         


Arg Val Leu Lys Glu Xaa Cys Asp Gln Lys Asp Leu Gln Ile Xaa Glu 
        515                 520                 525             


Ile Gln Glu Gln Leu Arg Asp Val Met Phe Tyr Leu Glu Xaa Gln Gln 
    530                 535                 540                 


Lys Ile Asn His Leu Pro Ala Glu Xaa Arg Gln Glu Ile Gln Glu Gly 
545                 550                 555                 560 


Gln Ile Asn Ile Ala Met Ala Ser Ala Ser Ser Pro Ala Ser Ser Gly 
                565                 570                 575     


Gly Ser Gly Lys Leu Pro Ser Arg Lys Gly Arg Ser Lys Arg Gly Lys 
            580                 585                 590         


<210> 4348
<211> 498
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<400> 4348
Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp Xaa Gly Leu Glu 
1               5                   10                  15      


Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn Asn Ser Pro Glu 
            20                  25                  30          


His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met Gly Tyr Arg Asn 
        35                  40                  45              


Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn Pro Ser Leu Glu 
    50                  55                  60                  


Xaa Ser Leu Ser Val Gln Leu Ser Asn Leu Gly Xaa Val Arg Xaa Leu 
65                  70                  75                  80  


Arg Xaa Lys Gln Arg Ile Gln Pro Gln Lys Xaa Ser Val Tyr Ile Glu 
                85                  90                  95      


Leu Ala Ala Cys Glu Phe Ser Glu Xaa Asp Val Xaa Asn Xaa Glu His 
            100                 105                 110         


His Gln Pro Ser Asn Asn Asp Leu Asn Xaa Xaa Glu Lys Arg Ala Ala 
        115                 120                 125             


Glu Arg His Pro Glu Lys Tyr Gln Gly Glu Ala Ala Ser Gly Cys Glu 
    130                 135                 140                 


Ser Glu Xaa Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser 
145                 150                 155                 160 


Asp Ile Leu Xaa Xaa Gln Gln Arg Asp Xaa Met Gln His Asn Leu Ile 
                165                 170                 175     


Lys Leu Gln Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln His 
            180                 185                 190         


Gly Ser Gln Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser 
        195                 200                 205             


Ala Leu Glu Asp Leu Arg Asn Pro Glu Gln Ser Xaa Ser Glu Lys Ala 
    210                 215                 220                 


Val Leu Xaa Ser Gln Lys Ser Ser Glu Tyr Pro Ile Ser Gln Asn Pro 
225                 230                 235                 240 


Glu Gly Leu Ser Ala Asp Lys Phe Glu Val Ser Ala Asp Ser Ser Xaa 
                245                 250                 255     


Ser Lys Asn Lys Glu Pro Gly Val Glu Arg Ser Ser Pro Ser Lys Cys 
            260                 265                 270         


Pro Ser Leu Asp Asp Arg Trp Tyr Met His Ser Cys Ser Gly Ser Leu 
        275                 280                 285             


Gln Asn Arg Asn Tyr Pro Ser Gln Glu Glu Leu Ile Lys Val Val Asp 
    290                 295                 300                 


Val Glu Glu Gln Gln Leu Glu Glu Ser Gly Pro His Asp Leu Xaa Glu 
305                 310                 315                 320 


Xaa Ser Tyr Leu Pro Arg Gln Asp Leu Glu Gly Xaa Pro Tyr Leu Glu 
                325                 330                 335     


Ser Gly Ile Ser Leu Phe Ser Asp Asp Pro Glu Ser Asp Pro Ser Glu 
            340                 345                 350         


Asp Arg Ala Pro Glu Ser Ala Arg Val Gly Asn Ile Pro Ser Ser Xaa 
        355                 360                 365             


Ser Ala Leu Lys Val Pro Gln Leu Lys Val Ala Glu Ser Ala Gln Ser 
    370                 375                 380                 


Pro Ala Ala Ala His Xaa Xaa Asp Xaa Ala Gly Tyr Asn Ala Met Glu 
385                 390                 395                 400 


Glu Ser Val Ser Arg Glu Lys Pro Glu Leu Xaa Ala Ser Xaa Glu Arg 
                405                 410                 415     


Val Asn Lys Arg Met Ser Met Val Val Ser Gly Leu Xaa Pro Glu Glu 
            420                 425                 430         


Phe Met Leu Val Tyr Lys Phe Ala Arg Lys His His Ile Xaa Leu Xaa 
        435                 440                 445             


Asn Leu Ile Xaa Glu Glu Xaa Xaa His Val Val Met Lys Xaa Asp Ala 
    450                 455                 460                 


Glu Phe Val Cys Glu Arg Xaa Leu Lys Tyr Phe Leu Gly Ile Ala Gly 
465                 470                 475                 480 


Gly Lys Trp Val Val Ser Tyr Phe Trp Val Xaa Gln Ser Ile Lys Glu 
                485                 490                 495     


Arg Lys 
        


<210> 4349
<211> 266
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<400> 4349
Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp Xaa Gly Leu Glu 
1               5                   10                  15      


Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn Asn Ser Pro Glu 
            20                  25                  30          


His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met Gly Tyr Arg Asn 
        35                  40                  45              


Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn Pro Ser Leu Gln 
    50                  55                  60                  


Glu Xaa Ser Leu Ser Val Gln Leu Ser Asn Leu Gly Xaa Val Arg Xaa 
65                  70                  75                  80  


Leu Arg Xaa Lys Gln Arg Ile Gln Pro Gln Lys Xaa Ser Val Tyr Ile 
                85                  90                  95      


Glu Leu Ala Ala Cys Glu Phe Ser Glu Xaa Asp Val Xaa Asn Xaa Glu 
            100                 105                 110         


His His Gln Pro Ser Asn Asn Asp Leu Asn Xaa Xaa Glu Lys Arg Ala 
        115                 120                 125             


Ala Glu Arg His Pro Glu Lys Tyr Gln Gly Glu Ala Ala Ser Gly Cys 
    130                 135                 140                 


Glu Ser Glu Xaa Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln 
145                 150                 155                 160 


Ser Asp Ile Leu Xaa Xaa Gln Gln Arg Asp Xaa Met Gln His Asn Leu 
                165                 170                 175     


Ile Lys Leu Gln Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln 
            180                 185                 190         


His Gly Ser Gln Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser 
        195                 200                 205             


Ser Ala Leu Glu Asp Leu Arg Asn Pro Glu Gln Ser Xaa Ser Glu Lys 
    210                 215                 220                 


Ala Val Leu Xaa Ser Gln Lys Ser Ser Glu Tyr Pro Ile Ser Gln Asn 
225                 230                 235                 240 


Pro Glu Gly Leu Ser Ala Asp Lys Phe Glu Val Ser Ala Asp Ser Ser 
                245                 250                 255     


Xaa Ser Lys Asn Lys Glu Pro Gly Val Glu 
            260                 265     


<210> 4350
<211> 173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 4350
Met Asp Ala Glu Phe Val Cys Glu Arg Xaa Leu Lys Tyr Phe Leu Gly 
1               5                   10                  15      


Ile Ala Gly Gly Lys Trp Val Val Ser Tyr Phe Trp Val Xaa Gln Ser 
            20                  25                  30          


Ile Lys Glu Arg Lys Met Leu Asn Glu His Asp Phe Glu Val Arg Gly 
        35                  40                  45              


Asp Val Val Asn Gly Arg Asn His Gln Gly Pro Lys Arg Ala Arg Glu 
    50                  55                  60                  


Ser Gln Asp Arg Lys Ile Phe Arg Gly Leu Glu Ile Cys Cys Tyr Gly 
65                  70                  75                  80  


Pro Phe Xaa Asn Met Pro Xaa Asp Gln Leu Glu Trp Met Val Gln Leu 
                85                  90                  95      


Cys Gly Ala Ser Val Val Lys Glu Leu Ser Ser Phe Xaa Leu Gly Xaa 
            100                 105                 110         


Gly Val His Pro Ile Val Val Val Gln Pro Asp Ala Trp Xaa Glu Asp 
        115                 120                 125             


Asn Gly Phe His Ala Ile Gly Gln Met Cys Glu Ala Pro Val Val Xaa 
    130                 135                 140                 


Arg Glu Trp Val Leu Asp Ser Val Ala Leu Tyr Gln Cys Gln Glu Leu 
145                 150                 155                 160 


Asp Xaa Tyr Leu Ile Pro Gln Ile Pro His Ser His Tyr 
                165                 170             


<210> 4351
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4351
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu 
            20              


<210> 4352
<211> 63
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<400> 4352
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Xaa Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu 
    50                  55                  60              


<210> 4353
<211> 222
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<400> 4353
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Xaa Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Xaa Lys Arg Ser Leu Gln Glu Ser Xaa Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Xaa Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Glu Xaa Ser Leu Ser Val Gln Leu Ser Asn Leu Gly Xaa 
145                 150                 155                 160 


Val Arg Xaa Leu Arg Xaa Lys Gln Arg Ile Gln Pro Gln Lys Xaa Ser 
                165                 170                 175     


Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Xaa Val Asn Lys 
            180                 185                 190         


Ala Xaa Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Xaa Pro 
        195                 200                 205             


Gln Gly Xaa Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys 
    210                 215                 220         


<210> 4354
<211> 623
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<400> 4354
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Xaa Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Xaa Lys Arg Ser Leu Gln Glu Ser Xaa Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Xaa Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Glu Xaa Ser Leu Ser Val Gln Leu Ser Asn Leu Gly Xaa 
145                 150                 155                 160 


Val Arg Xaa Leu Arg Xaa Lys Gln Arg Ile Gln Pro Gln Lys Xaa Ser 
                165                 170                 175     


Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Xaa Val Asn Lys 
            180                 185                 190         


Ala Xaa Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Xaa Pro 
        195                 200                 205             


Gln Gly Xaa Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala Ala 
    210                 215                 220                 


Cys Glu Phe Ser Glu Xaa Asp Val Xaa Asn Xaa Glu His His Gln Pro 
225                 230                 235                 240 


Ser Asn Asn Asp Leu Asn Xaa Xaa Glu Lys Arg Ala Ala Glu Arg His 
                245                 250                 255     


Pro Glu Lys Tyr Gln Gly Glu Ala Ala Ser Gly Cys Glu Ser Glu Xaa 
            260                 265                 270         


Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser Asp Ile Leu 
        275                 280                 285             


Xaa Xaa Gln Gln Arg Asp Xaa Met Gln His Asn Leu Ile Lys Leu Gln 
    290                 295                 300                 


Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln His Gly Ser Gln 
305                 310                 315                 320 


Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala Leu Glu 
                325                 330                 335     


Asp Leu Arg Asn Pro Glu Gln Ser Xaa Ser Glu Lys Ala Val Leu Xaa 
            340                 345                 350         


Ser Gln Lys Ser Ser Glu Tyr Pro Ile Ser Gln Asn Pro Glu Gly Leu 
        355                 360                 365             


Ser Ala Asp Lys Phe Glu Val Ser Ala Asp Ser Ser Xaa Ser Lys Asn 
    370                 375                 380                 


Lys Glu Pro Gly Val Glu Arg Ser Ser Pro Ser Lys Cys Pro Ser Leu 
385                 390                 395                 400 


Asp Asp Arg Trp Tyr Met His Ser Cys Ser Gly Ser Leu Gln Asn Arg 
                405                 410                 415     


Asn Tyr Pro Ser Gln Glu Glu Leu Ile Lys Val Val Asp Val Glu Glu 
            420                 425                 430         


Gln Gln Leu Glu Glu Ser Gly Pro His Asp Leu Xaa Glu Xaa Ser Tyr 
        435                 440                 445             


Leu Pro Arg Gln Asp Leu Glu Gly Xaa Pro Tyr Leu Glu Ser Gly Ile 
    450                 455                 460                 


Ser Leu Phe Ser Asp Asp Pro Glu Ser Asp Pro Ser Glu Asp Arg Ala 
465                 470                 475                 480 


Pro Glu Ser Ala Arg Val Gly Asn Ile Pro Ser Ser Xaa Ser Ala Leu 
                485                 490                 495     


Lys Val Pro Gln Leu Lys Val Ala Glu Ser Ala Gln Ser Pro Ala Ala 
            500                 505                 510         


Ala His Xaa Xaa Asp Xaa Ala Gly Tyr Asn Ala Met Glu Glu Ser Val 
        515                 520                 525             


Ser Arg Glu Lys Pro Glu Leu Xaa Ala Ser Xaa Glu Arg Val Asn Lys 
    530                 535                 540                 


Arg Met Ser Met Val Val Ser Gly Leu Xaa Pro Glu Glu Phe Met Leu 
545                 550                 555                 560 


Val Tyr Lys Phe Ala Arg Lys His His Ile Xaa Leu Xaa Asn Leu Ile 
                565                 570                 575     


Xaa Glu Glu Xaa Xaa His Val Val Met Lys Xaa Asp Ala Glu Phe Val 
            580                 585                 590         


Cys Glu Arg Xaa Leu Lys Tyr Phe Leu Gly Ile Ala Gly Gly Lys Trp 
        595                 600                 605             


Val Val Ser Tyr Phe Trp Val Xaa Gln Ser Ile Lys Glu Arg Lys 
    610                 615                 620             


<210> 4355
<211> 798
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<400> 4355
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Xaa Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Xaa Lys Arg Ser Leu Gln Glu Ser Xaa Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Xaa Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Xaa Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Xaa Val Arg Xaa Leu Arg Xaa Lys Gln Arg Ile Gln Pro Gln Lys Xaa 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Ala Ala Cys Glu Phe Ser Glu Xaa Asp Val 
            180                 185                 190         


Xaa Asn Xaa Glu His His Gln Pro Ser Asn Asn Asp Leu Asn Xaa Xaa 
        195                 200                 205             


Glu Lys Arg Ala Ala Glu Arg His Pro Glu Lys Tyr Gln Gly Ser Ser 
    210                 215                 220                 


Val Ser Asn Leu His Val Glu Pro Cys Gly Xaa Asn Xaa His Ala Ser 
225                 230                 235                 240 


Ser Leu Gln His Glu Asn Ser Ser Leu Leu Leu Xaa Lys Asp Arg Met 
                245                 250                 255     


Asn Val Glu Lys Ala Glu Phe Cys Asn Lys Ser Lys Gln Pro Gly Leu 
            260                 265                 270         


Ala Arg Ser Gln His Asn Arg Trp Ala Gly Ser Lys Glu Xaa Cys Asn 
        275                 280                 285             


Asp Arg Arg Xaa Pro Ser Xaa Glu Lys Lys Val Asp Leu Asn Ala Asp 
    290                 295                 300                 


Pro Leu Cys Glu Arg Lys Glu Trp Asn Lys Gln Lys Leu Pro Cys Ser 
305                 310                 315                 320 


Glu Asn Pro Arg Asp Xaa Glu Asp Val Pro Trp Ile Xaa Leu Asn Ser 
                325                 330                 335     


Ser Ile Gln Lys Val Asn Glu Trp Phe Ser Arg Ser Asp Glu Leu Leu 
            340                 345                 350         


Gly Ser Asp Asp Ser His Asp Gly Glu Ser Glu Ser Asn Ala Lys Val 
        355                 360                 365             


Ala Asp Val Leu Asp Val Leu Asn Glu Val Asp Glu Tyr Ser Gly Ser 
    370                 375                 380                 


Ser Glu Lys Ile Asp Leu Leu Ala Ser Asp Pro His Glu Ala Leu Ile 
385                 390                 395                 400 


Cys Lys Ser Glu Arg Val His Ser Lys Ser Val Glu Ser Asn Ile Glu 
                405                 410                 415     


Asp Lys Ile Phe Gly Lys Xaa Tyr Arg Lys Lys Ala Ser Leu Pro Asn 
            420                 425                 430         


Leu Ser His Val Xaa Glu Asn Leu Ile Ile Gly Ala Phe Val Xaa Glu 
        435                 440                 445             


Pro Gln Ile Ile Gln Glu Arg Pro Leu Xaa Asn Lys Leu Lys Arg Lys 
    450                 455                 460                 


Arg Arg Pro Xaa Ser Gly Leu His Pro Glu Asp Phe Ile Lys Lys Ala 
465                 470                 475                 480 


Asp Leu Ala Val Gln Lys Xaa Pro Glu Met Ile Asn Gln Gly Xaa Asn 
                485                 490                 495     


Gln Xaa Glu Gln Asn Gly Gln Val Met Asn Ile Xaa Asn Ser Gly His 
            500                 505                 510         


Glu Asn Lys Xaa Lys Gly Asp Ser Ile Gln Asn Glu Lys Asn Pro Asn 
        515                 520                 525             


Pro Ile Glu Ser Leu Glu Lys Glu Ser Ala Phe Lys Xaa Lys Ala Glu 
    530                 535                 540                 


Pro Ile Ser Ser Ser Ile Ser Asn Met Glu Leu Glu Leu Asn Ile His 
545                 550                 555                 560 


Asn Ser Lys Ala Pro Lys Lys Asn Arg Leu Arg Arg Lys Ser Ser Xaa 
                565                 570                 575     


Arg His Ile His Ala Leu Glu Leu Val Val Ser Arg Asn Leu Ser Pro 
            580                 585                 590         


Pro Asn Cys Xaa Glu Leu Gln Ile Asp Ser Cys Ser Ser Ser Glu Glu 
        595                 600                 605             


Ile Lys Lys Lys Lys Tyr Asn Gln Met Pro Val Arg His Ser Arg Asn 
    610                 615                 620                 


Leu Gln Leu Met Glu Gly Lys Glu Pro Ala Xaa Gly Ala Lys Lys Ser 
625                 630                 635                 640 


Asn Lys Pro Asn Glu Gln Xaa Ser Lys Arg His Asp Ser Asp Xaa Phe 
                645                 650                 655     


Pro Glu Leu Lys Leu Xaa Asn Ala Pro Gly Ser Phe Xaa Lys Cys Ser 
            660                 665                 670         


Asn Xaa Ser Glu Leu Lys Glu Phe Val Asn Pro Ser Leu Pro Arg Glu 
        675                 680                 685             


Glu Lys Glu Glu Lys Leu Glu Xaa Val Lys Val Ser Asn Asn Ala Glu 
    690                 695                 700                 


Asp Pro Lys Asp Leu Met Leu Ser Gly Glu Arg Val Leu Gln Xaa Glu 
705                 710                 715                 720 


Arg Ser Val Glu Ser Ser Ser Ile Ser Leu Val Pro Gly Xaa Asp Tyr 
                725                 730                 735     


Gly Xaa Gln Glu Ser Ile Ser Leu Leu Glu Val Ser Xaa Leu Gly Lys 
            740                 745                 750         


Ala Lys Xaa Glu Pro Asn Lys Cys Val Ser Gln Cys Ala Ala Phe Glu 
        755                 760                 765             


Asn Pro Lys Gly Leu Ile His Gly Cys Ser Lys Asp Asn Arg Asn Asp 
    770                 775                 780                 


Xaa Glu Gly Phe Lys Tyr Pro Leu Gly His Glu Val Asn His 
785                 790                 795             


<210> 4356
<211> 473
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<400> 4356
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Xaa Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Xaa Lys Arg Ser Leu Gln Glu Ser Xaa Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Xaa Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Xaa Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Xaa Val Arg Xaa Leu Arg Xaa Lys Gln Arg Ile Gln Pro Gln Lys Xaa 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Xaa Val Asn 
            180                 185                 190         


Lys Ala Xaa Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Xaa 
        195                 200                 205             


Pro Gln Gly Xaa Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Xaa Asp Val Xaa Asn Xaa Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Xaa Xaa Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Xaa Asn Xaa His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Xaa Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Xaa Cys Asn Asp Arg Arg Xaa Pro Ser Xaa 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Xaa Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Xaa Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Xaa 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn 
465                 470             


<210> 4357
<211> 649
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<400> 4357
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Xaa Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Xaa Lys Arg Ser Leu Gln Glu Ser Xaa Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Xaa Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Xaa Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Xaa Val Arg Xaa Leu Arg Xaa Lys Gln Arg Ile Gln Pro Gln Lys Xaa 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Xaa Val Asn 
            180                 185                 190         


Lys Ala Xaa Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Xaa 
        195                 200                 205             


Pro Gln Gly Xaa Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Xaa Asp Val Xaa Asn Xaa Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Xaa Xaa Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Xaa Asn Xaa His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Xaa Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Xaa Cys Asn Asp Arg Arg Xaa Pro Ser Xaa 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Xaa Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Xaa Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Xaa 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Xaa Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Xaa Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Xaa Asn Lys Leu Lys Arg Lys Arg Arg Pro Xaa Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Xaa 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Xaa Asn Gln Xaa Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Xaa Asn Ser Gly His Glu Asn Lys Xaa Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Xaa Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Xaa Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Xaa Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu 
                645                 


<210> 4358
<211> 699
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<400> 4358
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Xaa Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Xaa Lys Arg Ser Leu Gln Glu Ser Xaa Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Xaa Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Xaa Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Xaa Val Arg Xaa Leu Arg Xaa Lys Gln Arg Ile Gln Pro Gln Lys Xaa 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Xaa Val Asn 
            180                 185                 190         


Lys Ala Xaa Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Xaa 
        195                 200                 205             


Pro Gln Gly Xaa Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Xaa Asp Val Xaa Asn Xaa Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Xaa Xaa Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Glu Ala Ala Ser Gly Cys Glu Ser Glu 
            260                 265                 270         


Xaa Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser Asp Ile 
        275                 280                 285             


Leu Xaa Xaa Gln Gln Arg Asp Xaa Met Gln His Asn Leu Ile Lys Leu 
    290                 295                 300                 


Gln Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln His Gly Ser 
305                 310                 315                 320 


Gln Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala Leu 
                325                 330                 335     


Glu Asp Leu Arg Asn Pro Glu Gln Ser Xaa Ser Glu Lys Val Leu Xaa 
            340                 345                 350         


Ser Gln Lys Ser Ser Glu Tyr Pro Ile Ser Gln Asn Pro Glu Gly Leu 
        355                 360                 365             


Ser Ala Asp Lys Phe Glu Val Ser Ala Asp Ser Ser Xaa Ser Lys Asn 
    370                 375                 380                 


Lys Glu Pro Gly Val Glu Arg Ser Ser Pro Ser Lys Cys Pro Ser Leu 
385                 390                 395                 400 


Asp Asp Arg Trp Tyr Met His Ser Cys Ser Gly Ser Leu Gln Asn Arg 
                405                 410                 415     


Asn Tyr Pro Ser Gln Glu Glu Leu Ile Lys Val Val Asp Val Glu Glu 
            420                 425                 430         


Gln Gln Leu Glu Glu Ser Gly Pro His Asp Leu Xaa Glu Xaa Ser Tyr 
        435                 440                 445             


Leu Pro Arg Gln Asp Leu Glu Gly Xaa Pro Tyr Leu Glu Ser Gly Ile 
    450                 455                 460                 


Ser Leu Phe Ser Asp Asp Pro Glu Ser Asp Pro Ser Glu Asp Arg Ala 
465                 470                 475                 480 


Pro Glu Ser Ala Arg Val Gly Asn Ile Pro Ser Ser Xaa Ser Ala Leu 
                485                 490                 495     


Lys Val Pro Gln Leu Lys Val Ala Glu Ser Ala Gln Ser Pro Ala Ala 
            500                 505                 510         


Ala His Xaa Xaa Asp Xaa Ala Gly Tyr Asn Ala Met Glu Glu Ser Val 
        515                 520                 525             


Ser Arg Glu Lys Pro Glu Leu Xaa Ala Ser Xaa Glu Arg Val Asn Lys 
    530                 535                 540                 


Arg Met Ser Met Val Val Ser Gly Leu Xaa Pro Glu Glu Phe Met Leu 
545                 550                 555                 560 


Val Tyr Lys Phe Ala Arg Lys His His Ile Xaa Leu Xaa Asn Leu Ile 
                565                 570                 575     


Xaa Glu Glu Xaa Xaa His Val Val Met Lys Xaa Asp Ala Glu Phe Val 
            580                 585                 590         


Cys Glu Arg Xaa Leu Lys Tyr Phe Leu Gly Ile Ala Gly Gly Lys Trp 
        595                 600                 605             


Val Val Ser Tyr Phe Trp Val Xaa Gln Ser Ile Lys Glu Arg Lys Met 
    610                 615                 620                 


Leu Asn Glu His Asp Phe Glu Val Arg Gly Asp Val Val Asn Gly Arg 
625                 630                 635                 640 


Asn His Gln Gly Pro Lys Arg Ala Arg Glu Ser Gln Asp Arg Lys Ile 
                645                 650                 655     


Phe Arg Gly Leu Glu Ile Cys Cys Tyr Gly Pro Phe Xaa Asn Met Pro 
            660                 665                 670         


Xaa Gly Cys Pro Pro Asn Cys Gly Cys Ala Ala Arg Cys Leu Asp Arg 
        675                 680                 685             


Gly Gln Trp Leu Pro Cys Asn Trp Ala Asp Val 
    690                 695                 


<210> 4359
<211> 759
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<400> 4359
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Xaa Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Xaa Lys Arg Ser Leu Gln Glu Ser Xaa Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Xaa Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Xaa Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Xaa Val Arg Xaa Leu Arg Xaa Lys Gln Arg Ile Gln Pro Gln Lys Xaa 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Xaa Val Asn 
            180                 185                 190         


Lys Ala Xaa Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Xaa 
        195                 200                 205             


Pro Gln Gly Xaa Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Xaa Asp Val Xaa Asn Xaa Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Xaa Xaa Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Glu Ala Ala Ser Gly Cys Glu Ser Glu 
            260                 265                 270         


Xaa Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser Asp Ile 
        275                 280                 285             


Leu Xaa Xaa Gln Gln Arg Asp Xaa Met Gln His Asn Leu Ile Lys Leu 
    290                 295                 300                 


Gln Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln His Gly Ser 
305                 310                 315                 320 


Gln Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala Leu 
                325                 330                 335     


Glu Asp Leu Arg Asn Pro Glu Gln Ser Xaa Ser Glu Lys Val Leu Xaa 
            340                 345                 350         


Ser Gln Lys Ser Ser Glu Tyr Pro Ile Ser Gln Asn Pro Glu Gly Leu 
        355                 360                 365             


Ser Ala Asp Lys Phe Glu Val Ser Ala Asp Ser Ser Xaa Ser Lys Asn 
    370                 375                 380                 


Lys Glu Pro Gly Val Glu Arg Ser Ser Pro Ser Lys Cys Pro Ser Leu 
385                 390                 395                 400 


Asp Asp Arg Trp Tyr Met His Ser Cys Ser Gly Ser Leu Gln Asn Arg 
                405                 410                 415     


Asn Tyr Pro Ser Gln Glu Glu Leu Ile Lys Val Val Asp Val Glu Glu 
            420                 425                 430         


Gln Gln Leu Glu Glu Ser Gly Pro His Asp Leu Xaa Glu Xaa Ser Tyr 
        435                 440                 445             


Leu Pro Arg Gln Asp Leu Glu Gly Xaa Pro Tyr Leu Glu Ser Gly Ile 
    450                 455                 460                 


Ser Leu Phe Ser Asp Asp Pro Glu Ser Asp Pro Ser Glu Asp Arg Ala 
465                 470                 475                 480 


Pro Glu Ser Ala Arg Val Gly Asn Ile Pro Ser Ser Xaa Ser Ala Leu 
                485                 490                 495     


Lys Val Pro Gln Leu Lys Val Ala Glu Ser Ala Gln Ser Pro Ala Ala 
            500                 505                 510         


Ala His Xaa Xaa Asp Xaa Ala Gly Tyr Asn Ala Met Glu Glu Ser Val 
        515                 520                 525             


Ser Arg Glu Lys Pro Glu Leu Xaa Ala Ser Xaa Glu Arg Val Asn Lys 
    530                 535                 540                 


Arg Met Ser Met Val Val Ser Gly Leu Xaa Pro Glu Glu Phe Met Leu 
545                 550                 555                 560 


Val Tyr Lys Phe Ala Arg Lys His His Ile Xaa Leu Xaa Asn Leu Ile 
                565                 570                 575     


Xaa Glu Glu Xaa Xaa His Val Val Met Lys Xaa Asp Ala Glu Phe Val 
            580                 585                 590         


Cys Glu Arg Xaa Leu Lys Tyr Phe Leu Gly Ile Ala Gly Gly Lys Trp 
        595                 600                 605             


Val Val Ser Tyr Phe Trp Val Xaa Gln Ser Ile Lys Glu Arg Lys Met 
    610                 615                 620                 


Leu Asn Glu His Asp Phe Glu Val Arg Gly Asp Val Val Asn Gly Arg 
625                 630                 635                 640 


Asn His Gln Gly Pro Lys Arg Ala Arg Glu Ser Gln Asp Arg Lys Ile 
                645                 650                 655     


Phe Arg Gly Leu Glu Ile Cys Cys Tyr Gly Pro Phe Xaa Asn Met Pro 
            660                 665                 670         


Xaa Asp Gln Leu Glu Trp Met Val Gln Leu Cys Gly Ala Ser Val Val 
        675                 680                 685             


Lys Glu Leu Ser Ser Phe Xaa Leu Gly Xaa Gly Val His Pro Ile Val 
    690                 695                 700                 


Val Val Gln Pro Asp Ala Trp Xaa Glu Asp Asn Gly Phe His Ala Ile 
705                 710                 715                 720 


Gly Gln Met Cys Glu Ala Pro Val Val Xaa Arg Glu Trp Val Leu Asp 
                725                 730                 735     


Ser Val Ala Leu Tyr Gln Cys Gln Glu Leu Asp Xaa Tyr Leu Ile Pro 
            740                 745                 750         


Gln Ile Pro His Ser His Tyr 
        755                 


<210> 4360
<211> 1399
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1246)..(1246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1349)..(1349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1369)..(1369)
<223> Selenocysteine

<400> 4360
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Xaa Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Xaa Lys Arg Ser Leu Gln Glu Ser Xaa Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Xaa Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Xaa Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Xaa Val Arg Xaa Leu Arg Xaa Lys Gln Arg Ile Gln Pro Gln Lys Xaa 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Xaa Val Asn 
            180                 185                 190         


Lys Ala Xaa Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Xaa 
        195                 200                 205             


Pro Gln Gly Xaa Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Xaa Asp Val Xaa Asn Xaa Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Xaa Xaa Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Xaa Asn Xaa His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Xaa Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Xaa Cys Asn Asp Arg Arg Xaa Pro Ser Xaa 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Xaa Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Xaa Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Xaa 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Xaa Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Xaa Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Xaa Asn Lys Leu Lys Arg Lys Arg Arg Pro Xaa Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Xaa 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Xaa Asn Gln Xaa Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Xaa Asn Ser Gly His Glu Asn Lys Xaa Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Xaa Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Xaa Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Xaa Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Xaa Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Xaa 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Xaa Phe Pro Glu Leu Lys Leu Xaa Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Xaa Lys Cys Ser Asn Xaa Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Xaa Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Xaa Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Xaa Asp Tyr Gly Xaa Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Xaa Leu Gly Lys Ala Lys Xaa Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Xaa Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Xaa Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Xaa Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Xaa Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Xaa Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Xaa Val Asn Ile Xaa Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Xaa Gly Leu Ile Xaa Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Xaa 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Xaa Val 
    1010                 1015                 1020             


Ser Xaa  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Xaa Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Xaa Val  Asn Xaa Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Xaa Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Xaa Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Xaa His  Xaa His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Xaa Arg His Ser  Xaa Val Ala 
    1235                 1240                 1245             


Xaa Glu  Cys Leu Ser Lys Asn  Xaa Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Xaa Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Xaa Ala 
    1295                 1300                 1305             


Asn Xaa  Asn Xaa Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Xaa Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Ile Gly 
    1355                 1360                 1365             


Xaa Arg  Phe Leu Cys Leu Pro  Gln Ser Ile Tyr Arg  Ser Glu Leu 
    1370                 1375                 1380             


Asn Val  Tyr Ala Phe Gly Glu  His Ile Leu Gln Ile  Ser Lys Tyr 
    1385                 1390                 1395             


Ser 
    


<210> 4361
<211> 1863
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1246)..(1246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1349)..(1349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1393)..(1394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1399)..(1399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1449)..(1449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1456)..(1456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1485)..(1485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1548)..(1548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1550)..(1550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1561)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1597)..(1597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1619)..(1620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1622)..(1622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1643)..(1643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1658)..(1658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1675)..(1675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1677)..(1677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1681)..(1681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1684)..(1685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1691)..(1691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1700)..(1700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1720)..(1720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1777)..(1777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1799)..(1799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1802)..(1802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1816)..(1816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1834)..(1834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1852)..(1852)
<223> Selenocysteine

<400> 4361
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Xaa Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Xaa Lys Arg Ser Leu Gln Glu Ser Xaa Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Xaa Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Xaa Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Xaa Val Arg Xaa Leu Arg Xaa Lys Gln Arg Ile Gln Pro Gln Lys Xaa 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Xaa Val Asn 
            180                 185                 190         


Lys Ala Xaa Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Xaa 
        195                 200                 205             


Pro Gln Gly Xaa Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Xaa Asp Val Xaa Asn Xaa Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Xaa Xaa Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Xaa Asn Xaa His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Xaa Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Xaa Cys Asn Asp Arg Arg Xaa Pro Ser Xaa 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Xaa Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Xaa Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Xaa 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Xaa Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Xaa Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Xaa Asn Lys Leu Lys Arg Lys Arg Arg Pro Xaa Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Xaa 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Xaa Asn Gln Xaa Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Xaa Asn Ser Gly His Glu Asn Lys Xaa Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Xaa Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Xaa Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Xaa Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Xaa Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Xaa 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Xaa Phe Pro Glu Leu Lys Leu Xaa Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Xaa Lys Cys Ser Asn Xaa Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Xaa Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Xaa Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Xaa Asp Tyr Gly Xaa Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Xaa Leu Gly Lys Ala Lys Xaa Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Xaa Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Xaa Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Xaa Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Xaa Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Xaa Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Xaa Val Asn Ile Xaa Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Xaa Gly Leu Ile Xaa Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Xaa 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Xaa Val 
    1010                 1015                 1020             


Ser Xaa  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Xaa Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Xaa Val  Asn Xaa Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Xaa Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Xaa Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Xaa His  Xaa His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Xaa Arg His Ser  Xaa Val Ala 
    1235                 1240                 1245             


Xaa Glu  Cys Leu Ser Lys Asn  Xaa Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Xaa Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Xaa Ala 
    1295                 1300                 1305             


Asn Xaa  Asn Xaa Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Xaa Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Xaa Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Xaa Xaa Gln  Gln Arg Asp 
    1385                 1390                 1395             


Xaa Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Xaa Ser  Glu Lys Ala Val Leu  Xaa Ser Gln 
    1445                 1450                 1455             


Lys Ser  Ser Glu Tyr Pro Ile  Ser Gln Asn Pro Glu  Gly Leu Ser 
    1460                 1465                 1470             


Ala Asp  Lys Phe Glu Val Ser  Ala Asp Ser Ser Xaa  Ser Lys Asn 
    1475                 1480                 1485             


Lys Glu  Pro Gly Val Glu Arg  Ser Ser Pro Ser Lys  Cys Pro Ser 
    1490                 1495                 1500             


Leu Asp  Asp Arg Trp Tyr Met  His Ser Cys Ser Gly  Ser Leu Gln 
    1505                 1510                 1515             


Asn Arg  Asn Tyr Pro Ser Gln  Glu Glu Leu Ile Lys  Val Val Asp 
    1520                 1525                 1530             


Val Glu  Glu Gln Gln Leu Glu  Glu Ser Gly Pro His  Asp Leu Xaa 
    1535                 1540                 1545             


Glu Xaa  Ser Tyr Leu Pro Arg  Gln Asp Leu Glu Gly  Xaa Pro Tyr 
    1550                 1555                 1560             


Leu Glu  Ser Gly Ile Ser Leu  Phe Ser Asp Asp Pro  Glu Ser Asp 
    1565                 1570                 1575             


Pro Ser  Glu Asp Arg Ala Pro  Glu Ser Ala Arg Val  Gly Asn Ile 
    1580                 1585                 1590             


Pro Ser  Ser Xaa Ser Ala Leu  Lys Val Pro Gln Leu  Lys Val Ala 
    1595                 1600                 1605             


Glu Ser  Ala Gln Ser Pro Ala  Ala Ala His Xaa Xaa  Asp Xaa Ala 
    1610                 1615                 1620             


Gly Tyr  Asn Ala Met Glu Glu  Ser Val Ser Arg Glu  Lys Pro Glu 
    1625                 1630                 1635             


Leu Xaa  Ala Ser Xaa Glu Arg  Val Asn Lys Arg Met  Ser Met Val 
    1640                 1645                 1650             


Val Ser  Gly Leu Xaa Pro Glu  Glu Phe Met Leu Val  Tyr Lys Phe 
    1655                 1660                 1665             


Ala Arg  Lys His His Ile Xaa  Leu Xaa Asn Leu Ile  Xaa Glu Glu 
    1670                 1675                 1680             


Xaa Xaa  His Val Val Met Lys  Xaa Asp Ala Glu Phe  Val Cys Glu 
    1685                 1690                 1695             


Arg Xaa  Leu Lys Tyr Phe Leu  Gly Ile Ala Gly Gly  Lys Trp Val 
    1700                 1705                 1710             


Val Ser  Tyr Phe Trp Val Xaa  Gln Ser Ile Lys Glu  Arg Lys Met 
    1715                 1720                 1725             


Leu Asn  Glu His Asp Phe Glu  Val Arg Gly Asp Val  Val Asn Gly 
    1730                 1735                 1740             


Arg Asn  His Gln Gly Pro Lys  Arg Ala Arg Glu Ser  Gln Asp Arg 
    1745                 1750                 1755             


Lys Ile  Phe Arg Gly Leu Glu  Ile Cys Cys Tyr Gly  Pro Phe Xaa 
    1760                 1765                 1770             


Asn Met  Pro Xaa Asp Gln Leu  Glu Trp Met Val Gln  Leu Cys Gly 
    1775                 1780                 1785             


Ala Ser  Val Val Lys Glu Leu  Ser Ser Phe Xaa Leu  Gly Xaa Gly 
    1790                 1795                 1800             


Val His  Pro Ile Val Val Val  Gln Pro Asp Ala Trp  Xaa Glu Asp 
    1805                 1810                 1815             


Asn Gly  Phe His Ala Ile Gly  Gln Met Cys Glu Ala  Pro Val Val 
    1820                 1825                 1830             


Xaa Arg  Glu Trp Val Leu Asp  Ser Val Ala Leu Tyr  Gln Cys Gln 
    1835                 1840                 1845             


Glu Leu  Asp Xaa Tyr Leu Ile  Pro Gln Ile Pro His  Ser His Tyr 
    1850                 1855                 1860             


<210> 4362
<211> 1884
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1246)..(1246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1349)..(1349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1393)..(1394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1399)..(1399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1449)..(1449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1477)..(1477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1569)..(1569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1571)..(1571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1618)..(1618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1643)..(1643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1661)..(1661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1664)..(1664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1679)..(1679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1696)..(1696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1698)..(1698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1702)..(1702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1705)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1712)..(1712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1741)..(1741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1794)..(1794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1798)..(1798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1820)..(1820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1823)..(1823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1837)..(1837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1855)..(1855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1873)..(1873)
<223> Selenocysteine

<400> 4362
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Xaa Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Xaa Lys Arg Ser Leu Gln Glu Ser Xaa Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Xaa Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Xaa Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Xaa Val Arg Xaa Leu Arg Xaa Lys Gln Arg Ile Gln Pro Gln Lys Xaa 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Xaa Val Asn 
            180                 185                 190         


Lys Ala Xaa Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Xaa 
        195                 200                 205             


Pro Gln Gly Xaa Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Xaa Asp Val Xaa Asn Xaa Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Xaa Xaa Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Xaa Asn Xaa His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Xaa Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Xaa Cys Asn Asp Arg Arg Xaa Pro Ser Xaa 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Xaa Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Xaa Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Xaa 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Xaa Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Xaa Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Xaa Asn Lys Leu Lys Arg Lys Arg Arg Pro Xaa Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Xaa 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Xaa Asn Gln Xaa Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Xaa Asn Ser Gly His Glu Asn Lys Xaa Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Xaa Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Xaa Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Xaa Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Xaa Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Xaa 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Xaa Phe Pro Glu Leu Lys Leu Xaa Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Xaa Lys Cys Ser Asn Xaa Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Xaa Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Xaa Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Xaa Asp Tyr Gly Xaa Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Xaa Leu Gly Lys Ala Lys Xaa Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Xaa Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Xaa Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Xaa Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Xaa Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Xaa Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Xaa Val Asn Ile Xaa Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Xaa Gly Leu Ile Xaa Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Xaa 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Xaa Val 
    1010                 1015                 1020             


Ser Xaa  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Xaa Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Xaa Val  Asn Xaa Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Xaa Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Xaa Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Xaa His  Xaa His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Xaa Arg His Ser  Xaa Val Ala 
    1235                 1240                 1245             


Xaa Glu  Cys Leu Ser Lys Asn  Xaa Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Xaa Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Xaa Ala 
    1295                 1300                 1305             


Asn Xaa  Asn Xaa Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Xaa Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Xaa Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Xaa Xaa Gln  Gln Arg Asp 
    1385                 1390                 1395             


Xaa Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Xaa Ser  Glu Lys Asp Ser His  Ile His Gly 
    1445                 1450                 1455             


Gln Arg  Asn Asn Ser Met Phe  Ser Lys Arg Pro Arg  Glu His Ile 
    1460                 1465                 1470             


Ser Val  Leu Xaa Ser Gln Lys  Ser Ser Glu Tyr Pro  Ile Ser Gln 
    1475                 1480                 1485             


Asn Pro  Glu Gly Leu Ser Ala  Asp Lys Phe Glu Val  Ser Ala Asp 
    1490                 1495                 1500             


Ser Ser  Xaa Ser Lys Asn Lys  Glu Pro Gly Val Glu  Arg Ser Ser 
    1505                 1510                 1515             


Pro Ser  Lys Cys Pro Ser Leu  Asp Asp Arg Trp Tyr  Met His Ser 
    1520                 1525                 1530             


Cys Ser  Gly Ser Leu Gln Asn  Arg Asn Tyr Pro Ser  Gln Glu Glu 
    1535                 1540                 1545             


Leu Ile  Lys Val Val Asp Val  Glu Glu Gln Gln Leu  Glu Glu Ser 
    1550                 1555                 1560             


Gly Pro  His Asp Leu Xaa Glu  Xaa Ser Tyr Leu Pro  Arg Gln Asp 
    1565                 1570                 1575             


Leu Glu  Gly Xaa Pro Tyr Leu  Glu Ser Gly Ile Ser  Leu Phe Ser 
    1580                 1585                 1590             


Asp Asp  Pro Glu Ser Asp Pro  Ser Glu Asp Arg Ala  Pro Glu Ser 
    1595                 1600                 1605             


Ala Arg  Val Gly Asn Ile Pro  Ser Ser Xaa Ser Ala  Leu Lys Val 
    1610                 1615                 1620             


Pro Gln  Leu Lys Val Ala Glu  Ser Ala Gln Ser Pro  Ala Ala Ala 
    1625                 1630                 1635             


His Xaa  Xaa Asp Xaa Ala Gly  Tyr Asn Ala Met Glu  Glu Ser Val 
    1640                 1645                 1650             


Ser Arg  Glu Lys Pro Glu Leu  Xaa Ala Ser Xaa Glu  Arg Val Asn 
    1655                 1660                 1665             


Lys Arg  Met Ser Met Val Val  Ser Gly Leu Xaa Pro  Glu Glu Phe 
    1670                 1675                 1680             


Met Leu  Val Tyr Lys Phe Ala  Arg Lys His His Ile  Xaa Leu Xaa 
    1685                 1690                 1695             


Asn Leu  Ile Xaa Glu Glu Xaa  Xaa His Val Val Met  Lys Xaa Asp 
    1700                 1705                 1710             


Ala Glu  Phe Val Cys Glu Arg  Xaa Leu Lys Tyr Phe  Leu Gly Ile 
    1715                 1720                 1725             


Ala Gly  Gly Lys Trp Val Val  Ser Tyr Phe Trp Val  Xaa Gln Ser 
    1730                 1735                 1740             


Ile Lys  Glu Arg Lys Met Leu  Asn Glu His Asp Phe  Glu Val Arg 
    1745                 1750                 1755             


Gly Asp  Val Val Asn Gly Arg  Asn His Gln Gly Pro  Lys Arg Ala 
    1760                 1765                 1770             


Arg Glu  Ser Gln Asp Arg Lys  Ile Phe Arg Gly Leu  Glu Ile Cys 
    1775                 1780                 1785             


Cys Tyr  Gly Pro Phe Xaa Asn  Met Pro Xaa Asp Gln  Leu Glu Trp 
    1790                 1795                 1800             


Met Val  Gln Leu Cys Gly Ala  Ser Val Val Lys Glu  Leu Ser Ser 
    1805                 1810                 1815             


Phe Xaa  Leu Gly Xaa Gly Val  His Pro Ile Val Val  Val Gln Pro 
    1820                 1825                 1830             


Asp Ala  Trp Xaa Glu Asp Asn  Gly Phe His Ala Ile  Gly Gln Met 
    1835                 1840                 1845             


Cys Glu  Ala Pro Val Val Xaa  Arg Glu Trp Val Leu  Asp Ser Val 
    1850                 1855                 1860             


Ala Leu  Tyr Gln Cys Gln Glu  Leu Asp Xaa Tyr Leu  Ile Pro Gln 
    1865                 1870                 1875             


Ile Pro  His Ser His Tyr 
    1880                 


<210> 4363
<211> 721
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<400> 4363
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Xaa Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Xaa Lys Arg Ser Leu Gln Glu Ser Xaa Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Xaa Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Xaa Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Xaa Val Arg Xaa Leu Arg Xaa Lys Gln Arg Ile Gln Pro Gln Lys Xaa 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Xaa Val Asn 
            180                 185                 190         


Lys Ala Xaa Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Xaa 
        195                 200                 205             


Pro Gln Gly Xaa Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Gly 
    210                 215                 220                 


Glu Ala Ala Ser Gly Cys Glu Ser Glu Xaa Ser Val Ser Glu Asp Cys 
225                 230                 235                 240 


Ser Gly Leu Ser Ser Gln Ser Asp Ile Leu Xaa Xaa Gln Gln Arg Asp 
                245                 250                 255     


Xaa Met Gln His Asn Leu Ile Lys Leu Gln Gln Glu Met Ala Glu Leu 
            260                 265                 270         


Glu Ala Val Leu Glu Gln His Gly Ser Gln Pro Ser Asn Ser Tyr Pro 
        275                 280                 285             


Ser Ile Ile Ser Asp Ser Ser Ala Leu Glu Asp Leu Arg Asn Pro Glu 
    290                 295                 300                 


Gln Ser Xaa Ser Glu Lys Ala Val Leu Xaa Ser Gln Lys Ser Ser Glu 
305                 310                 315                 320 


Tyr Pro Ile Ser Gln Asn Pro Glu Gly Leu Ser Ala Asp Lys Phe Glu 
                325                 330                 335     


Val Ser Ala Asp Ser Ser Xaa Ser Lys Asn Lys Glu Pro Gly Val Glu 
            340                 345                 350         


Arg Ser Ser Pro Ser Lys Cys Pro Ser Leu Asp Asp Arg Trp Tyr Met 
        355                 360                 365             


His Ser Cys Ser Gly Ser Leu Gln Asn Arg Asn Tyr Pro Ser Gln Glu 
    370                 375                 380                 


Glu Leu Ile Lys Val Val Asp Val Glu Glu Gln Gln Leu Glu Glu Ser 
385                 390                 395                 400 


Gly Pro His Asp Leu Xaa Glu Xaa Ser Tyr Leu Pro Arg Gln Asp Leu 
                405                 410                 415     


Glu Gly Xaa Pro Tyr Leu Glu Ser Gly Ile Ser Leu Phe Ser Asp Asp 
            420                 425                 430         


Pro Glu Ser Asp Pro Ser Glu Asp Arg Ala Pro Glu Ser Ala Arg Val 
        435                 440                 445             


Gly Asn Ile Pro Ser Ser Xaa Ser Ala Leu Lys Val Pro Gln Leu Lys 
    450                 455                 460                 


Val Ala Glu Ser Ala Gln Ser Pro Ala Ala Ala His Xaa Xaa Asp Xaa 
465                 470                 475                 480 


Ala Gly Tyr Asn Ala Met Glu Glu Ser Val Ser Arg Glu Lys Pro Glu 
                485                 490                 495     


Leu Xaa Ala Ser Xaa Glu Arg Val Asn Lys Arg Met Ser Met Val Val 
            500                 505                 510         


Ser Gly Leu Xaa Pro Glu Glu Phe Met Leu Val Tyr Lys Phe Ala Arg 
        515                 520                 525             


Lys His His Ile Xaa Leu Xaa Asn Leu Ile Xaa Glu Glu Xaa Xaa His 
    530                 535                 540                 


Val Val Met Lys Xaa Asp Ala Glu Phe Val Cys Glu Arg Xaa Leu Lys 
545                 550                 555                 560 


Tyr Phe Leu Gly Ile Ala Gly Gly Lys Trp Val Val Ser Tyr Phe Trp 
                565                 570                 575     


Val Xaa Gln Ser Ile Lys Glu Arg Lys Met Leu Asn Glu His Asp Phe 
            580                 585                 590         


Glu Val Arg Gly Asp Val Val Asn Gly Arg Asn His Gln Gly Pro Lys 
        595                 600                 605             


Arg Ala Arg Glu Ser Gln Asp Arg Lys Ile Phe Arg Gly Leu Glu Ile 
    610                 615                 620                 


Cys Cys Tyr Gly Pro Phe Xaa Asn Met Pro Xaa Asp Gln Leu Glu Trp 
625                 630                 635                 640 


Met Val Gln Leu Cys Gly Ala Ser Val Val Lys Glu Leu Ser Ser Phe 
                645                 650                 655     


Xaa Leu Gly Xaa Gly Val His Pro Ile Val Val Val Gln Pro Asp Ala 
            660                 665                 670         


Trp Xaa Glu Asp Asn Gly Phe His Ala Ile Gly Gln Met Cys Glu Ala 
        675                 680                 685             


Pro Val Val Xaa Arg Glu Trp Val Leu Asp Ser Val Ala Leu Tyr Gln 
    690                 695                 700                 


Cys Gln Glu Leu Asp Xaa Tyr Leu Ile Pro Gln Ile Pro His Ser His 
705                 710                 715                 720 


Tyr 
    


<210> 4364
<211> 98
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<400> 4364
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Xaa Lys Cys Asp His Ile Phe Cys Lys Ser Leu Gln 
        35                  40                  45              


Glu Ser Xaa Arg Phe Ser Gln Leu Val Glu Glu Leu Leu Lys Ile Ile 
    50                  55                  60                  


Cys Ala Phe Gln Leu Asp Xaa Gly Leu Glu Tyr Ala Asn Ser Tyr Asn 
65                  70                  75                  80  


Phe Ala Lys Lys Glu Asn Asn Ser Pro Glu His Leu Lys Asp Glu Val 
                85                  90                  95      


Ser Ile 
        


<210> 4365
<211> 622
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<400> 4365
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Xaa Lys Cys Asp His Ile Phe Cys Lys Ser Leu Gln 
        35                  40                  45              


Glu Ser Xaa Arg Phe Ser Gln Leu Val Glu Glu Leu Leu Lys Ile Ile 
    50                  55                  60                  


Cys Ala Phe Gln Leu Asp Xaa Gly Leu Glu Tyr Ala Asn Ser Tyr Asn 
65                  70                  75                  80  


Phe Ala Lys Lys Glu Asn Asn Ser Pro Glu His Leu Lys Asp Glu Val 
                85                  90                  95      


Ser Ile Ile Gln Ser Met Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu 
            100                 105                 110         


Gln Ser Glu Pro Glu Asn Pro Ser Leu Gln Glu Xaa Ser Leu Ser Val 
        115                 120                 125             


Gln Leu Ser Asn Leu Gly Xaa Val Arg Xaa Leu Arg Xaa Lys Gln Arg 
    130                 135                 140                 


Ile Gln Pro Gln Lys Xaa Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser 
145                 150                 155                 160 


Ser Glu Asp Xaa Val Asn Lys Ala Xaa Tyr Cys Ser Val Gly Asp Gln 
                165                 170                 175     


Glu Leu Leu Gln Ile Xaa Pro Gln Gly Xaa Arg Asp Glu Ile Ser Leu 
            180                 185                 190         


Asp Ser Ala Lys Lys Ala Ala Cys Glu Phe Ser Glu Xaa Asp Val Xaa 
        195                 200                 205             


Asn Xaa Glu His His Gln Pro Ser Asn Asn Asp Leu Asn Xaa Xaa Glu 
    210                 215                 220                 


Lys Arg Ala Ala Glu Arg His Pro Glu Lys Tyr Gln Gly Ser Ser Val 
225                 230                 235                 240 


Ser Asn Leu His Val Glu Pro Cys Gly Xaa Asn Xaa His Ala Ser Ser 
                245                 250                 255     


Leu Gln His Glu Asn Ser Ser Leu Leu Leu Xaa Lys Asp Arg Met Asn 
            260                 265                 270         


Val Glu Lys Ala Glu Phe Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala 
        275                 280                 285             


Arg Ser Gln His Asn Arg Trp Ala Gly Ser Lys Glu Xaa Cys Asn Asp 
    290                 295                 300                 


Arg Arg Xaa Pro Ser Xaa Glu Lys Lys Val Asp Leu Asn Ala Asp Pro 
305                 310                 315                 320 


Leu Cys Glu Arg Lys Glu Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu 
                325                 330                 335     


Asn Pro Arg Asp Xaa Glu Asp Val Pro Trp Ile Xaa Leu Asn Ser Ser 
            340                 345                 350         


Ile Gln Lys Val Asn Glu Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly 
        355                 360                 365             


Ser Asp Asp Ser His Asp Gly Glu Ser Glu Ser Asn Ala Lys Val Ala 
    370                 375                 380                 


Asp Val Leu Asp Val Leu Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser 
385                 390                 395                 400 


Glu Lys Ile Asp Leu Leu Ala Ser Asp Pro His Glu Ala Leu Ile Cys 
                405                 410                 415     


Lys Ser Glu Arg Val His Ser Lys Ser Val Glu Ser Asn Ile Glu Asp 
            420                 425                 430         


Lys Ile Phe Gly Lys Xaa Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu 
        435                 440                 445             


Ser His Val Xaa Glu Asn Leu Ile Ile Gly Ala Phe Val Xaa Glu Pro 
    450                 455                 460                 


Gln Ile Ile Gln Glu Arg Pro Leu Xaa Asn Lys Leu Lys Arg Lys Arg 
465                 470                 475                 480 


Arg Pro Xaa Ser Gly Leu His Pro Glu Asp Phe Ile Lys Lys Ala Asp 
                485                 490                 495     


Leu Ala Val Gln Lys Xaa Pro Glu Met Ile Asn Gln Gly Xaa Asn Gln 
            500                 505                 510         


Xaa Glu Gln Asn Gly Gln Val Met Asn Ile Xaa Asn Ser Gly His Glu 
        515                 520                 525             


Asn Lys Xaa Lys Gly Asp Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro 
    530                 535                 540                 


Ile Glu Ser Leu Glu Lys Glu Ser Ala Phe Lys Xaa Lys Ala Glu Pro 
545                 550                 555                 560 


Ile Ser Ser Ser Ile Ser Asn Met Glu Leu Glu Leu Asn Ile His Asn 
                565                 570                 575     


Ser Lys Ala Pro Lys Lys Asn Arg Leu Arg Arg Lys Ser Ser Xaa Arg 
            580                 585                 590         


His Ile His Ala Leu Glu Leu Val Val Ser Arg Asn Leu Ser Pro Pro 
        595                 600                 605             


Asn Cys Xaa Glu Leu Gln Ile Asp Ser Cys Ser Ser Ser Glu 
    610                 615                 620         


<210> 4366
<211> 59
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<400> 4366
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Xaa Lys Cys Asp His Ile Phe Cys Lys Val Leu Leu 
        35                  40                  45              


Cys Cys Pro Ser Trp Ser Xaa Val Val Arg Ser 
    50                  55                  


<210> 4367
<211> 354
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<400> 4367
Met His Ser Cys Ser Gly Ser Leu Gln Asn Arg Asn Tyr Pro Ser Gln 
1               5                   10                  15      


Glu Glu Leu Ile Lys Val Val Asp Val Glu Glu Gln Gln Leu Glu Glu 
            20                  25                  30          


Ser Gly Pro His Asp Leu Xaa Glu Xaa Ser Tyr Leu Pro Arg Gln Asp 
        35                  40                  45              


Leu Glu Gly Xaa Pro Tyr Leu Glu Ser Gly Ile Ser Leu Phe Ser Asp 
    50                  55                  60                  


Asp Pro Glu Ser Asp Pro Ser Glu Asp Arg Ala Pro Glu Ser Ala Arg 
65                  70                  75                  80  


Val Gly Asn Ile Pro Ser Ser Xaa Ser Ala Leu Lys Val Pro Gln Leu 
                85                  90                  95      


Lys Val Ala Glu Ser Ala Gln Ser Pro Ala Ala Ala His Xaa Xaa Asp 
            100                 105                 110         


Xaa Ala Gly Tyr Asn Ala Met Glu Glu Ser Val Ser Arg Glu Lys Pro 
        115                 120                 125             


Glu Leu Xaa Ala Ser Xaa Glu Arg Val Asn Lys Arg Met Ser Met Val 
    130                 135                 140                 


Val Ser Gly Leu Xaa Pro Glu Glu Phe Met Leu Val Tyr Lys Phe Ala 
145                 150                 155                 160 


Arg Lys His His Ile Xaa Leu Xaa Asn Leu Ile Xaa Glu Glu Xaa Xaa 
                165                 170                 175     


His Val Val Met Lys Xaa Asp Ala Glu Phe Val Cys Glu Arg Xaa Leu 
            180                 185                 190         


Lys Tyr Phe Leu Gly Ile Ala Gly Gly Lys Trp Val Val Ser Tyr Phe 
        195                 200                 205             


Trp Val Xaa Gln Ser Ile Lys Glu Arg Lys Met Leu Asn Glu His Asp 
    210                 215                 220                 


Phe Glu Val Arg Gly Asp Val Val Asn Gly Arg Asn His Gln Gly Pro 
225                 230                 235                 240 


Lys Arg Ala Arg Glu Ser Gln Asp Arg Lys Ile Phe Arg Gly Leu Glu 
                245                 250                 255     


Ile Cys Cys Tyr Gly Pro Phe Xaa Asn Met Pro Xaa Asp Gln Leu Glu 
            260                 265                 270         


Trp Met Val Gln Leu Cys Gly Ala Ser Val Val Lys Glu Leu Ser Ser 
        275                 280                 285             


Phe Xaa Leu Gly Xaa Gly Val His Pro Ile Val Val Val Gln Pro Asp 
    290                 295                 300                 


Ala Trp Xaa Glu Asp Asn Gly Phe His Ala Ile Gly Gln Met Cys Glu 
305                 310                 315                 320 


Ala Pro Val Val Xaa Arg Glu Trp Val Leu Asp Ser Val Ala Leu Tyr 
                325                 330                 335     


Gln Cys Gln Glu Leu Asp Xaa Tyr Leu Ile Pro Gln Ile Pro His Ser 
            340                 345                 350         


His Tyr 
        


<210> 4368
<211> 572
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<400> 4368
Met Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu 
1               5                   10                  15      


Cys Lys Asn Asp Ile Xaa Lys Arg Ser Leu Gln Glu Ser Xaa Arg Phe 
            20                  25                  30          


Ser Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu 
        35                  40                  45              


Asp Xaa Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu 
    50                  55                  60                  


Asn Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser 
65                  70                  75                  80  


Met Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu 
                85                  90                  95      


Asn Pro Ser Leu Gln Glu Xaa Ser Leu Ser Val Gln Leu Ser Asn Leu 
            100                 105                 110         


Gly Xaa Val Arg Xaa Leu Arg Xaa Lys Gln Arg Ile Gln Pro Gln Lys 
        115                 120                 125             


Xaa Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Xaa Val 
    130                 135                 140                 


Asn Lys Ala Xaa Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile 
145                 150                 155                 160 


Xaa Pro Gln Gly Xaa Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys 
                165                 170                 175     


Ala Ala Cys Glu Phe Ser Glu Xaa Asp Val Xaa Asn Xaa Glu His His 
            180                 185                 190         


Gln Pro Ser Asn Asn Asp Leu Asn Xaa Xaa Glu Lys Arg Ala Ala Glu 
        195                 200                 205             


Arg His Pro Glu Lys Tyr Gln Gly Glu Ala Ala Ser Gly Cys Glu Ser 
    210                 215                 220                 


Glu Xaa Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser Asp 
225                 230                 235                 240 


Ile Leu Xaa Xaa Gln Gln Arg Asp Xaa Met Gln His Asn Leu Ile Lys 
                245                 250                 255     


Leu Gln Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln His Gly 
            260                 265                 270         


Ser Gln Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala 
        275                 280                 285             


Leu Glu Asp Leu Arg Asn Pro Glu Gln Ser Xaa Ser Glu Lys Ala Val 
    290                 295                 300                 


Leu Xaa Ser Gln Lys Ser Ser Glu Tyr Pro Ile Ser Gln Asn Pro Glu 
305                 310                 315                 320 


Gly Leu Ser Ala Asp Lys Phe Glu Val Ser Ala Asp Ser Ser Xaa Ser 
                325                 330                 335     


Lys Asn Lys Glu Pro Gly Val Glu Arg Ser Ser Pro Ser Lys Cys Pro 
            340                 345                 350         


Ser Leu Asp Asp Arg Trp Tyr Met His Ser Cys Ser Gly Ser Leu Gln 
        355                 360                 365             


Asn Arg Asn Tyr Pro Ser Gln Glu Glu Leu Ile Lys Val Val Asp Val 
    370                 375                 380                 


Glu Glu Gln Gln Leu Glu Glu Ser Gly Pro His Asp Leu Xaa Glu Xaa 
385                 390                 395                 400 


Ser Tyr Leu Pro Arg Gln Asp Leu Glu Gly Xaa Pro Tyr Leu Glu Ser 
                405                 410                 415     


Gly Ile Ser Leu Phe Ser Asp Asp Pro Glu Ser Asp Pro Ser Glu Asp 
            420                 425                 430         


Arg Ala Pro Glu Ser Ala Arg Val Gly Asn Ile Pro Ser Ser Xaa Ser 
        435                 440                 445             


Ala Leu Lys Val Pro Gln Leu Lys Val Ala Glu Ser Ala Gln Ser Pro 
    450                 455                 460                 


Ala Ala Ala His Xaa Xaa Asp Xaa Ala Gly Tyr Asn Ala Met Glu Glu 
465                 470                 475                 480 


Ser Val Ser Arg Glu Lys Pro Glu Leu Xaa Ala Ser Xaa Glu Arg Val 
                485                 490                 495     


Asn Lys Arg Met Ser Met Val Val Ser Gly Leu Xaa Pro Glu Glu Phe 
            500                 505                 510         


Met Leu Val Tyr Lys Phe Ala Arg Lys His His Ile Xaa Leu Xaa Asn 
        515                 520                 525             


Leu Ile Xaa Glu Glu Xaa Xaa His Val Val Met Lys Xaa Asp Ala Glu 
    530                 535                 540                 


Phe Val Cys Glu Arg Xaa Leu Lys Tyr Phe Leu Gly Ile Ala Gly Gly 
545                 550                 555                 560 


Lys Trp Val Val Ser Tyr Phe Trp Val Xaa Gln Ser 
                565                 570         


<210> 4369
<211> 1816
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1195)..(1195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1260)..(1260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1346)..(1347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1402)..(1402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1409)..(1409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1438)..(1438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1501)..(1501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1503)..(1503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1514)..(1514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1550)..(1550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1572)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1575)..(1575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1593)..(1593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1611)..(1611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1628)..(1628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1630)..(1630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1634)..(1634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1637)..(1638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1644)..(1644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1653)..(1653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1673)..(1673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1726)..(1726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1730)..(1730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1752)..(1752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1755)..(1755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1769)..(1769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1805)..(1805)
<223> Selenocysteine

<400> 4369
Met Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu 
1               5                   10                  15      


Cys Lys Asn Asp Ile Xaa Lys Arg Ser Leu Gln Glu Ser Xaa Arg Phe 
            20                  25                  30          


Ser Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu 
        35                  40                  45              


Asp Xaa Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu 
    50                  55                  60                  


Asn Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser 
65                  70                  75                  80  


Met Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu 
                85                  90                  95      


Asn Pro Ser Leu Gln Glu Xaa Ser Leu Ser Val Gln Leu Ser Asn Leu 
            100                 105                 110         


Gly Xaa Val Arg Xaa Leu Arg Xaa Lys Gln Arg Ile Gln Pro Gln Lys 
        115                 120                 125             


Xaa Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Xaa Val 
    130                 135                 140                 


Asn Lys Ala Xaa Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile 
145                 150                 155                 160 


Xaa Pro Gln Gly Xaa Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys 
                165                 170                 175     


Ala Ala Cys Glu Phe Ser Glu Xaa Asp Val Xaa Asn Xaa Glu His His 
            180                 185                 190         


Gln Pro Ser Asn Asn Asp Leu Asn Xaa Xaa Glu Lys Arg Ala Ala Glu 
        195                 200                 205             


Arg His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val 
    210                 215                 220                 


Glu Pro Cys Gly Xaa Asn Xaa His Ala Ser Ser Leu Gln His Glu Asn 
225                 230                 235                 240 


Ser Ser Leu Leu Leu Xaa Lys Asp Arg Met Asn Val Glu Lys Ala Glu 
                245                 250                 255     


Phe Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn 
            260                 265                 270         


Arg Trp Ala Gly Ser Lys Glu Xaa Cys Asn Asp Arg Arg Xaa Pro Ser 
        275                 280                 285             


Xaa Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys 
    290                 295                 300                 


Glu Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Xaa 
305                 310                 315                 320 


Glu Asp Val Pro Trp Ile Xaa Leu Asn Ser Ser Ile Gln Lys Val Asn 
                325                 330                 335     


Glu Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His 
            340                 345                 350         


Asp Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val 
        355                 360                 365             


Leu Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu 
    370                 375                 380                 


Leu Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val 
385                 390                 395                 400 


His Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys 
                405                 410                 415     


Xaa Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Xaa Glu 
            420                 425                 430         


Asn Leu Ile Ile Gly Ala Phe Val Xaa Glu Pro Gln Ile Ile Gln Glu 
        435                 440                 445             


Arg Pro Leu Xaa Asn Lys Leu Lys Arg Lys Arg Arg Pro Xaa Ser Gly 
    450                 455                 460                 


Leu His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys 
465                 470                 475                 480 


Xaa Pro Glu Met Ile Asn Gln Gly Xaa Asn Gln Xaa Glu Gln Asn Gly 
                485                 490                 495     


Gln Val Met Asn Ile Xaa Asn Ser Gly His Glu Asn Lys Xaa Lys Gly 
            500                 505                 510         


Asp Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu 
        515                 520                 525             


Lys Glu Ser Ala Phe Lys Xaa Lys Ala Glu Pro Ile Ser Ser Ser Ile 
    530                 535                 540                 


Ser Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys 
545                 550                 555                 560 


Lys Asn Arg Leu Arg Arg Lys Ser Ser Xaa Arg His Ile His Ala Leu 
                565                 570                 575     


Glu Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Xaa Glu Leu 
            580                 585                 590         


Gln Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr 
        595                 600                 605             


Asn Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly 
    610                 615                 620                 


Lys Glu Pro Ala Xaa Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln 
625                 630                 635                 640 


Xaa Ser Lys Arg His Asp Ser Asp Xaa Phe Pro Glu Leu Lys Leu Xaa 
                645                 650                 655     


Asn Ala Pro Gly Ser Phe Xaa Lys Cys Ser Asn Xaa Ser Glu Leu Lys 
            660                 665                 670         


Glu Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu 
        675                 680                 685             


Glu Xaa Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met 
    690                 695                 700                 


Leu Ser Gly Glu Arg Val Leu Gln Xaa Glu Arg Ser Val Glu Ser Ser 
705                 710                 715                 720 


Ser Ile Ser Leu Val Pro Gly Xaa Asp Tyr Gly Xaa Gln Glu Ser Ile 
                725                 730                 735     


Ser Leu Leu Glu Val Ser Xaa Leu Gly Lys Ala Lys Xaa Glu Pro Asn 
            740                 745                 750         


Lys Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile 
        755                 760                 765             


His Gly Cys Ser Lys Asp Asn Arg Asn Asp Xaa Glu Gly Phe Lys Tyr 
    770                 775                 780                 


Pro Leu Gly His Glu Val Asn His Ser Arg Glu Xaa Ser Ile Glu Met 
785                 790                 795                 800 


Glu Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Xaa Phe Lys Val 
                805                 810                 815     


Ser Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu 
            820                 825                 830         


Glu Glu Cys Ala Xaa Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln 
        835                 840                 845             


Ser Pro Lys Val Xaa Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly 
    850                 855                 860                 


Lys Asn Glu Ser Asn Ile Lys Pro Val Gln Xaa Val Asn Ile Xaa Ala 
865                 870                 875                 880 


Gly Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys 
                885                 890                 895     


Cys Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg 
            900                 905                 910         


Gly Asn Glu Xaa Gly Leu Ile Xaa Pro Asn Lys His Gly Leu Leu Gln 
        915                 920                 925             


Asn Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys 
    930                 935                 940                 


Xaa Lys Cys Lys Lys Asn Leu Leu Glu Glu Asn Phe Glu Glu His Ser 
945                 950                 955                 960 


Met Ser Pro Glu Arg Glu Met Gly Asn Glu Asn Ile Pro Ser Xaa Val 
                965                 970                 975     


Ser Xaa Ile Ser Arg Asn Asn Ile Arg Glu Asn Val Phe Lys Glu Ala 
            980                 985                 990         


Ser Ser Ser Asn Ile Asn Glu Val  Gly Ser Ser Xaa Asn  Glu Val Gly 
        995                 1000                 1005             


Ser Ser  Ile Asn Glu Ile Gly  Ser Ser Asp Glu Asn  Ile Gln Ala 
    1010                 1015                 1020             


Glu Leu  Gly Arg Asn Arg Gly  Pro Lys Leu Asn Ala  Met Leu Arg 
    1025                 1030                 1035             


Leu Gly  Val Leu Gln Pro Glu  Val Tyr Lys Gln Ser  Leu Pro Gly 
    1040                 1045                 1050             


Ser Asn  Cys Lys His Pro Glu  Ile Lys Lys Gln Glu  Tyr Glu Glu 
    1055                 1060                 1065             


Val Val  Gln Xaa Val Asn Xaa  Asp Phe Ser Pro Tyr  Leu Ile Ser 
    1070                 1075                 1080             


Asp Asn  Leu Glu Gln Pro Met  Gly Ser Ser His Ala  Ser Gln Val 
    1085                 1090                 1095             


Cys Ser  Glu Xaa Pro Asp Asp  Leu Leu Asp Asp Gly  Glu Ile Lys 
    1100                 1105                 1110             


Glu Asp  Xaa Ser Phe Ala Glu  Asn Asp Ile Lys Glu  Ser Ser Ala 
    1115                 1120                 1125             


Val Phe  Ser Lys Ser Val Gln  Lys Gly Glu Leu Ser  Arg Ser Pro 
    1130                 1135                 1140             


Ser Pro  Phe Xaa His Xaa His  Leu Ala Gln Gly Tyr  Arg Arg Gly 
    1145                 1150                 1155             


Ala Lys  Lys Leu Glu Ser Ser  Glu Glu Asn Leu Ser  Ser Glu Asp 
    1160                 1165                 1170             


Glu Glu  Leu Pro Cys Phe Gln  His Leu Leu Phe Gly  Lys Val Asn 
    1175                 1180                 1185             


Asn Ile  Pro Ser Gln Ser Xaa  Arg His Ser Xaa Val  Ala Xaa Glu 
    1190                 1195                 1200             


Cys Leu  Ser Lys Asn Xaa Glu  Glu Asn Leu Leu Ser  Leu Lys Asn 
    1205                 1210                 1215             


Ser Leu  Asn Asp Cys Ser Asn  Gln Val Ile Leu Ala  Lys Ala Ser 
    1220                 1225                 1230             


Gln Glu  His His Leu Ser Glu  Glu Xaa Lys Cys Ser  Ala Ser Leu 
    1235                 1240                 1245             


Phe Ser  Ser Gln Cys Ser Glu  Leu Glu Asp Leu Xaa  Ala Asn Xaa 
    1250                 1255                 1260             


Asn Xaa  Gln Asp Pro Phe Leu  Ile Gly Ser Ser Lys  Gln Met Arg 
    1265                 1270                 1275             


His Gln  Ser Glu Ser Gln Gly  Val Gly Leu Ser Asp  Lys Glu Leu 
    1280                 1285                 1290             


Val Ser  Asp Asp Glu Glu Arg  Gly Xaa Gly Leu Glu  Glu Asn Asn 
    1295                 1300                 1305             


Gln Glu  Glu Gln Ser Met Asp  Ser Asn Leu Gly Glu  Ala Ala Ser 
    1310                 1315                 1320             


Gly Cys  Glu Ser Glu Xaa Ser  Val Ser Glu Asp Cys  Ser Gly Leu 
    1325                 1330                 1335             


Ser Ser  Gln Ser Asp Ile Leu  Xaa Xaa Gln Gln Arg  Asp Xaa Met 
    1340                 1345                 1350             


Gln His  Asn Leu Ile Lys Leu  Gln Gln Glu Met Ala  Glu Leu Glu 
    1355                 1360                 1365             


Ala Val  Leu Glu Gln His Gly  Ser Gln Pro Ser Asn  Ser Tyr Pro 
    1370                 1375                 1380             


Ser Ile  Ile Ser Asp Ser Ser  Ala Leu Glu Asp Leu  Arg Asn Pro 
    1385                 1390                 1395             


Glu Gln  Ser Xaa Ser Glu Lys  Ala Val Leu Xaa Ser  Gln Lys Ser 
    1400                 1405                 1410             


Ser Glu  Tyr Pro Ile Ser Gln  Asn Pro Glu Gly Leu  Ser Ala Asp 
    1415                 1420                 1425             


Lys Phe  Glu Val Ser Ala Asp  Ser Ser Xaa Ser Lys  Asn Lys Glu 
    1430                 1435                 1440             


Pro Gly  Val Glu Arg Ser Ser  Pro Ser Lys Cys Pro  Ser Leu Asp 
    1445                 1450                 1455             


Asp Arg  Trp Tyr Met His Ser  Cys Ser Gly Ser Leu  Gln Asn Arg 
    1460                 1465                 1470             


Asn Tyr  Pro Ser Gln Glu Glu  Leu Ile Lys Val Val  Asp Val Glu 
    1475                 1480                 1485             


Glu Gln  Gln Leu Glu Glu Ser  Gly Pro His Asp Leu  Xaa Glu Xaa 
    1490                 1495                 1500             


Ser Tyr  Leu Pro Arg Gln Asp  Leu Glu Gly Xaa Pro  Tyr Leu Glu 
    1505                 1510                 1515             


Ser Gly  Ile Ser Leu Phe Ser  Asp Asp Pro Glu Ser  Asp Pro Ser 
    1520                 1525                 1530             


Glu Asp  Arg Ala Pro Glu Ser  Ala Arg Val Gly Asn  Ile Pro Ser 
    1535                 1540                 1545             


Ser Xaa  Ser Ala Leu Lys Val  Pro Gln Leu Lys Val  Ala Glu Ser 
    1550                 1555                 1560             


Ala Gln  Ser Pro Ala Ala Ala  His Xaa Xaa Asp Xaa  Ala Gly Tyr 
    1565                 1570                 1575             


Asn Ala  Met Glu Glu Ser Val  Ser Arg Glu Lys Pro  Glu Leu Xaa 
    1580                 1585                 1590             


Ala Ser  Xaa Glu Arg Val Asn  Lys Arg Met Ser Met  Val Val Ser 
    1595                 1600                 1605             


Gly Leu  Xaa Pro Glu Glu Phe  Met Leu Val Tyr Lys  Phe Ala Arg 
    1610                 1615                 1620             


Lys His  His Ile Xaa Leu Xaa  Asn Leu Ile Xaa Glu  Glu Xaa Xaa 
    1625                 1630                 1635             


His Val  Val Met Lys Xaa Asp  Ala Glu Phe Val Cys  Glu Arg Xaa 
    1640                 1645                 1650             


Leu Lys  Tyr Phe Leu Gly Ile  Ala Gly Gly Lys Trp  Val Val Ser 
    1655                 1660                 1665             


Tyr Phe  Trp Val Xaa Gln Ser  Ile Lys Glu Arg Lys  Met Leu Asn 
    1670                 1675                 1680             


Glu His  Asp Phe Glu Val Arg  Gly Asp Val Val Asn  Gly Arg Asn 
    1685                 1690                 1695             


His Gln  Gly Pro Lys Arg Ala  Arg Glu Ser Gln Asp  Arg Lys Ile 
    1700                 1705                 1710             


Phe Arg  Gly Leu Glu Ile Cys  Cys Tyr Gly Pro Phe  Xaa Asn Met 
    1715                 1720                 1725             


Pro Xaa  Asp Gln Leu Glu Trp  Met Val Gln Leu Cys  Gly Ala Ser 
    1730                 1735                 1740             


Val Val  Lys Glu Leu Ser Ser  Phe Xaa Leu Gly Xaa  Gly Val His 
    1745                 1750                 1755             


Pro Ile  Val Val Val Gln Pro  Asp Ala Trp Xaa Glu  Asp Asn Gly 
    1760                 1765                 1770             


Phe His  Ala Ile Gly Gln Met  Cys Glu Ala Pro Val  Val Xaa Arg 
    1775                 1780                 1785             


Glu Trp  Val Leu Asp Ser Val  Ala Leu Tyr Gln Cys  Gln Glu Leu 
    1790                 1795                 1800             


Asp Xaa  Tyr Leu Ile Pro Gln  Ile Pro His Ser His  Tyr 
    1805                 1810                 1815     


<210> 4370
<211> 177
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<400> 4370
Met Asn Val Glu Lys Ala Glu Phe Cys Asn Lys Ser Lys Gln Pro Gly 
1               5                   10                  15      


Leu Ala Arg Ser Gln His Asn Arg Trp Ala Gly Ser Lys Glu Xaa Cys 
            20                  25                  30          


Asn Asp Arg Arg Xaa Pro Ser Xaa Glu Lys Lys Val Asp Leu Asn Ala 
        35                  40                  45              


Asp Pro Leu Cys Glu Arg Lys Glu Trp Asn Lys Gln Lys Leu Pro Cys 
    50                  55                  60                  


Ser Glu Asn Pro Arg Asp Xaa Glu Asp Val Pro Trp Ile Xaa Leu Asn 
65                  70                  75                  80  


Ser Ser Ile Gln Lys Val Asn Glu Trp Phe Ser Arg Ser Asp Glu Leu 
                85                  90                  95      


Leu Gly Ser Asp Asp Ser His Asp Gly Glu Ser Glu Ser Asn Ala Lys 
            100                 105                 110         


Val Ala Asp Val Leu Asp Val Leu Asn Glu Val Asp Glu Tyr Ser Gly 
        115                 120                 125             


Ser Ser Glu Lys Ile Asp Leu Leu Ala Ser Asp Pro His Glu Ala Leu 
    130                 135                 140                 


Ile Cys Lys Ser Glu Arg Val His Ser Lys Ser Val Glu Ser Asn Ile 
145                 150                 155                 160 


Glu Asp Lys Ile Phe Gly Lys Xaa Tyr Arg Lys Lys Ala Ser Leu Pro 
                165                 170                 175     


Asn 
    


<210> 4371
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<400> 4371
Met Ser Asp Ser Lys Lys Xaa Trp Leu Gln Tyr Gln Leu Glu Trp Met 
1               5                   10                  15      


Val Gln Leu Cys Gly Ala Ser Val Val Lys Glu Leu Ser Ser Phe Xaa 
            20                  25                  30          


Leu Gly Xaa Gly Val His Pro Ile Val Val Val Gln Pro Asp Ala Trp 
        35                  40                  45              


Xaa Glu Asp Asn Gly Phe His Ala Ile Gly Gln Met Cys Glu Ala Pro 
    50                  55                  60                  


Val Val Xaa Arg Glu Trp Val Leu Asp Ser Val Ala Leu Tyr Gln Cys 
65                  70                  75                  80  


Gln Glu Leu Asp Xaa Tyr Leu Ile Pro Gln Ile Pro His Ser His Tyr 
                85                  90                  95      


<210> 4372
<211> 242
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<400> 4372
Xaa Ile Pro Ser Gln Ser Xaa Arg His Ser Xaa Val Ala Xaa Glu Cys 
1               5                   10                  15      


Leu Ser Lys Asn Xaa Glu Glu Asn Leu Leu Ser Leu Lys Asn Ser Leu 
            20                  25                  30          


Asn Asp Cys Ser Asn Gln Val Ile Leu Ala Lys Ala Ser Gln Glu His 
        35                  40                  45              


His Leu Ser Glu Glu Xaa Lys Cys Ser Ala Ser Leu Phe Ser Ser Gln 
    50                  55                  60                  


Cys Ser Glu Leu Glu Asp Leu Xaa Ala Asn Xaa Asn Xaa Gln Asp Pro 
65                  70                  75                  80  


Phe Leu Ile Gly Ser Ser Lys Gln Met Arg His Gln Ser Glu Ser Gln 
                85                  90                  95      


Gly Val Gly Leu Ser Asp Lys Glu Leu Val Ser Asp Asp Glu Glu Arg 
            100                 105                 110         


Gly Xaa Gly Leu Glu Glu Asn Asn Gln Glu Glu Gln Ser Met Asp Ser 
        115                 120                 125             


Asn Leu Gly Glu Ala Ala Ser Gly Cys Glu Ser Glu Xaa Ser Val Ser 
    130                 135                 140                 


Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser Asp Ile Leu Xaa Xaa Gln 
145                 150                 155                 160 


Gln Arg Asp Xaa Met Gln His Asn Leu Ile Lys Leu Gln Gln Glu Met 
                165                 170                 175     


Ala Glu Leu Glu Ala Val Leu Glu Gln His Gly Ser Gln Pro Ser Asn 
            180                 185                 190         


Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala Leu Glu Asp Leu Arg 
        195                 200                 205             


Asn Pro Glu Gln Ser Xaa Ser Glu Lys Val Leu Xaa Ser Gln Lys Ser 
    210                 215                 220                 


Ser Glu Tyr Pro Ile Ser Gln Asn Pro Glu Gly Leu Ser Ala Asp Lys 
225                 230                 235                 240 


Phe Glu 
        


<210> 4373
<211> 437
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<400> 4373
Xaa Leu Asp Ser Ala Lys Lys Ala Ala Cys Glu Phe Ser Glu Xaa Asp 
1               5                   10                  15      


Val Xaa Asn Xaa Glu His His Gln Pro Ser Asn Asn Asp Leu Asn Xaa 
            20                  25                  30          


Xaa Glu Lys Arg Ala Ala Glu Arg His Pro Glu Lys Tyr Gln Gly Ser 
        35                  40                  45              


Ser Val Ser Asn Leu His Val Glu Pro Cys Gly Xaa Asn Xaa His Ala 
    50                  55                  60                  


Ser Ser Leu Gln His Glu Asn Ser Ser Leu Leu Leu Xaa Lys Asp Arg 
65                  70                  75                  80  


Met Asn Val Glu Lys Ala Glu Phe Cys Asn Lys Ser Lys Gln Pro Gly 
                85                  90                  95      


Leu Ala Arg Ser Gln His Asn Arg Trp Ala Gly Ser Lys Glu Xaa Cys 
            100                 105                 110         


Asn Asp Arg Arg Xaa Pro Ser Xaa Glu Lys Lys Val Asp Leu Asn Ala 
        115                 120                 125             


Asp Pro Leu Cys Glu Arg Lys Glu Trp Asn Lys Gln Lys Leu Pro Cys 
    130                 135                 140                 


Ser Glu Asn Pro Arg Asp Xaa Glu Asp Val Pro Trp Ile Xaa Leu Asn 
145                 150                 155                 160 


Ser Ser Ile Gln Lys Val Asn Glu Trp Phe Ser Arg Ser Asp Glu Leu 
                165                 170                 175     


Leu Gly Ser Asp Asp Ser His Asp Gly Glu Ser Glu Ser Asn Ala Lys 
            180                 185                 190         


Val Ala Asp Val Leu Asp Val Leu Asn Glu Val Asp Glu Tyr Ser Gly 
        195                 200                 205             


Ser Ser Glu Lys Ile Asp Leu Leu Ala Ser Asp Pro His Glu Ala Leu 
    210                 215                 220                 


Ile Cys Lys Ser Glu Arg Val His Ser Lys Ser Val Glu Ser Asn Ile 
225                 230                 235                 240 


Glu Asp Lys Ile Phe Gly Lys Xaa Tyr Arg Lys Lys Ala Ser Leu Pro 
                245                 250                 255     


Asn Leu Ser His Val Xaa Glu Asn Leu Ile Ile Gly Ala Phe Val Xaa 
            260                 265                 270         


Glu Pro Gln Ile Ile Gln Glu Arg Pro Leu Xaa Asn Lys Leu Lys Arg 
        275                 280                 285             


Lys Arg Arg Pro Xaa Ser Gly Leu His Pro Glu Asp Phe Ile Lys Lys 
    290                 295                 300                 


Ala Asp Leu Ala Val Gln Lys Xaa Pro Glu Met Ile Asn Gln Gly Xaa 
305                 310                 315                 320 


Asn Gln Xaa Glu Gln Asn Gly Gln Val Met Asn Ile Xaa Asn Ser Gly 
                325                 330                 335     


His Glu Asn Lys Xaa Lys Gly Asp Ser Ile Gln Asn Glu Lys Asn Pro 
            340                 345                 350         


Asn Pro Ile Glu Ser Leu Glu Lys Glu Ser Ala Phe Lys Xaa Lys Ala 
        355                 360                 365             


Glu Pro Ile Ser Ser Ser Ile Ser Asn Met Glu Leu Glu Leu Asn Ile 
    370                 375                 380                 


His Asn Ser Lys Ala Pro Lys Lys Asn Arg Leu Arg Arg Lys Ser Ser 
385                 390                 395                 400 


Xaa Arg His Ile His Ala Leu Glu Leu Val Val Ser Arg Asn Leu Ser 
                405                 410                 415     


Pro Pro Asn Cys Xaa Glu Leu Gln Ile Asp Ser Cys Ser Ser Ser Glu 
            420                 425                 430         


Glu Ile Lys Lys Lys 
        435         


<210> 4374
<211> 319
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<400> 4374
Xaa Gln Leu Asp Xaa Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala 
1               5                   10                  15      


Lys Lys Glu Asn Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile 
            20                  25                  30          


Ile Gln Ser Met Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser 
        35                  40                  45              


Glu Pro Glu Asn Pro Ser Leu Glu Xaa Ser Leu Ser Val Gln Leu Ser 
    50                  55                  60                  


Asn Leu Gly Xaa Val Arg Xaa Leu Arg Xaa Lys Gln Arg Ile Gln Pro 
65                  70                  75                  80  


Gln Lys Xaa Ser Val Tyr Ile Glu Leu Ala Ala Cys Glu Phe Ser Glu 
                85                  90                  95      


Xaa Asp Val Xaa Asn Xaa Glu His His Gln Pro Ser Asn Asn Asp Leu 
            100                 105                 110         


Asn Xaa Xaa Glu Lys Arg Ala Ala Glu Arg His Pro Glu Lys Tyr Gln 
        115                 120                 125             


Gly Ser Ser Val Ser Asn Leu His Val Glu Pro Cys Gly Xaa Asn Xaa 
    130                 135                 140                 


His Ala Ser Ser Leu Gln His Glu Asn Ser Ser Leu Leu Leu Xaa Lys 
145                 150                 155                 160 


Asp Arg Met Asn Val Glu Lys Ala Glu Phe Cys Asn Lys Ser Lys Gln 
                165                 170                 175     


Pro Gly Leu Ala Arg Ser Gln His Asn Arg Trp Ala Gly Ser Lys Glu 
            180                 185                 190         


Xaa Cys Asn Asp Arg Arg Xaa Pro Ser Xaa Glu Lys Lys Val Asp Leu 
        195                 200                 205             


Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu Trp Asn Lys Gln Lys Leu 
    210                 215                 220                 


Pro Cys Ser Glu Asn Pro Arg Asp Xaa Glu Asp Val Pro Trp Ile Xaa 
225                 230                 235                 240 


Leu Asn Ser Ser Ile Gln Lys Val Asn Glu Trp Phe Ser Arg Ser Asp 
                245                 250                 255     


Glu Leu Leu Gly Ser Asp Asp Ser His Asp Gly Glu Ser Glu Ser Asn 
            260                 265                 270         


Ala Lys Val Ala Asp Val Leu Asp Val Leu Asn Glu Val Asp Glu Tyr 
        275                 280                 285             


Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu Ala Ser Asp Pro His Glu 
    290                 295                 300                 


Ala Leu Ile Cys Lys Ser Glu Arg Val His Ser Lys Ser Val Glu 
305                 310                 315                 


<210> 4375
<211> 3418
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1128)..(1128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1282)..(1282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1304)..(1304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1317)..(1317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1325)..(1325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1346)..(1346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1354)..(1354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1359)..(1359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1378)..(1378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1388)..(1388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1403)..(1403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1410)..(1410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1412)..(1412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1426)..(1426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1430)..(1430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1499)..(1499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1505)..(1505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1520)..(1520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1526)..(1526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1553)..(1553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1557)..(1557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1566)..(1566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1624)..(1624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1629)..(1629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1647)..(1647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1653)..(1653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1656)..(1656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1673)..(1673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1679)..(1679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1684)..(1684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1707)..(1707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1723)..(1723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1738)..(1738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1785)..(1785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1803)..(1803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1815)..(1815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1858)..(1858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1867)..(1867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1887)..(1887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1915)..(1915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1954)..(1954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1974)..(1974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1980)..(1980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2007)..(2007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2026)..(2026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2031)..(2031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2035)..(2035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2060)..(2060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2088)..(2088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2097)..(2097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2125)..(2125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2169)..(2169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2197)..(2197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2199)..(2199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2207)..(2207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2214)..(2214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2225)..(2225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2241)..(2241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2250)..(2250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2255)..(2255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2310)..(2310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2314)..(2314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2331)..(2331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2337)..(2338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2350)..(2350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2367)..(2367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2388)..(2388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2398)..(2399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2403)..(2403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2412)..(2412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2469)..(2469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2471)..(2471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2482)..(2482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2515)..(2515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2517)..(2517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2542)..(2542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2564)..(2564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2575)..(2575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2607)..(2607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2662)..(2662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2681)..(2681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2685)..(2685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2703)..(2703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2708)..(2708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2713)..(2713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2722)..(2722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2746)..(2746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2766)..(2766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2783)..(2783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2790)..(2790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2834)..(2834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2867)..(2867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2880)..(2881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2891)..(2891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2967)..(2968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3001)..(3001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3013)..(3013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3030)..(3030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3033)..(3033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3085)..(3085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3137)..(3137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3158)..(3158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3165)..(3165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3193)..(3193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3195)..(3195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3199)..(3199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3204)..(3204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3211)..(3211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3242)..(3242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3249)..(3249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3288)..(3288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3306)..(3306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3310)..(3310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3323)..(3323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3349)..(3349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3357)..(3357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3369)..(3369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3371)..(3371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3374)..(3374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3387)..(3388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3401)..(3401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3411)..(3411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3413)..(3414)
<223> Selenocysteine

<400> 4375
Met Pro Ile Gly Ser Lys Glu Arg Pro Xaa Phe Phe Glu Ile Phe Lys 
1               5                   10                  15      


Xaa Arg Cys Asn Lys Ala Asp Leu Gly Pro Ile Ser Leu Asn Trp Phe 
            20                  25                  30          


Glu Glu Leu Ser Ser Glu Ala Pro Pro Tyr Asn Ser Glu Pro Ala Glu 
        35                  40                  45              


Glu Ser Glu His Lys Asn Asn Asn Tyr Glu Pro Asn Leu Phe Lys Xaa 
    50                  55                  60                  


Pro Gln Arg Lys Pro Ser Tyr Asn Gln Leu Ala Ser Xaa Pro Ile Ile 
65                  70                  75                  80  


Phe Lys Glu Gln Gly Leu Xaa Leu Pro Leu Tyr Gln Ser Pro Val Lys 
                85                  90                  95      


Glu Leu Asp Lys Phe Lys Leu Asp Leu Gly Arg Asn Val Pro Asn Ser 
            100                 105                 110         


Arg His Lys Ser Leu Arg Xaa Val Lys Xaa Lys Met Asp Gln Ala Asp 
        115                 120                 125             


Asp Val Ser Cys Pro Leu Leu Asn Ser Cys Leu Ser Glu Ser Pro Val 
    130                 135                 140                 


Val Leu Gln Cys Xaa His Val Xaa Pro Gln Arg Asp Lys Ser Val Val 
145                 150                 155                 160 


Cys Gly Ser Leu Phe His Xaa Pro Lys Phe Val Lys Gly Arg Gln Xaa 
                165                 170                 175     


Pro Lys His Ile Ser Glu Ser Leu Gly Ala Glu Val Asp Pro Asp Met 
            180                 185                 190         


Ser Trp Ser Ser Ser Leu Ala Xaa Pro Pro Xaa Leu Ser Ser Xaa Val 
        195                 200                 205             


Leu Ile Val Arg Asn Glu Glu Ala Ser Glu Xaa Val Phe Pro His Asp 
    210                 215                 220                 


Xaa Xaa Ala Asn Val Lys Ser Tyr Phe Ser Asn His Asp Glu Ser Leu 
225                 230                 235                 240 


Lys Lys Asn Asp Arg Phe Ile Ala Ser Val Xaa Asp Ser Glu Asn Xaa 
                245                 250                 255     


Asn Gln Arg Glu Ala Ala Ser His Gly Phe Gly Lys Xaa Ser Gly Asn 
            260                 265                 270         


Ser Phe Lys Val Asn Ser Cys Lys Asp His Ile Gly Lys Ser Met Pro 
        275                 280                 285             


Asn Val Leu Glu Asp Glu Val Tyr Glu Xaa Val Val Asp Xaa Ser Glu 
    290                 295                 300                 


Glu Asp Ser Phe Ser Leu Cys Phe Ser Lys Cys Arg Xaa Lys Asn Leu 
305                 310                 315                 320 


Gln Lys Val Arg Xaa Ser Lys Xaa Arg Lys Lys Ile Phe His Glu Ala 
                325                 330                 335     


Asn Ala Asp Glu Cys Glu Lys Ser Lys Asn Gln Val Lys Glu Lys Tyr 
            340                 345                 350         


Ser Phe Val Ser Glu Val Glu Pro Asn Asp Xaa Asp Pro Leu Asp Ser 
        355                 360                 365             


Asn Val Ala Asn Gln Lys Pro Phe Glu Ser Gly Ser Asp Lys Ile Ser 
    370                 375                 380                 


Lys Glu Val Val Pro Ser Leu Ala Cys Glu Trp Ser Gln Leu Xaa Leu 
385                 390                 395                 400 


Ser Gly Leu Asn Gly Ala Gln Met Glu Lys Ile Pro Leu Leu His Ile 
                405                 410                 415     


Ser Ser Cys Asp Gln Asn Ile Ser Glu Lys Asp Leu Leu Asp Xaa Glu 
            420                 425                 430         


Asn Lys Arg Lys Lys Asp Phe Leu Xaa Ser Glu Asn Ser Leu Pro Arg 
        435                 440                 445             


Ile Ser Ser Leu Pro Lys Ser Glu Lys Pro Leu Asn Glu Glu Xaa Val 
    450                 455                 460                 


Val Asn Lys Arg Asp Glu Glu Gln His Leu Glu Ser His Xaa Asp Cys 
465                 470                 475                 480 


Ile Leu Ala Val Lys Gln Ala Ile Ser Gly Xaa Ser Pro Val Ala Ser 
                485                 490                 495     


Ser Phe Gln Gly Ile Lys Lys Ser Ile Phe Arg Ile Arg Glu Ser Pro 
            500                 505                 510         


Lys Glu Xaa Phe Asn Ala Ser Phe Ser Gly His Met Xaa Asp Pro Asn 
        515                 520                 525             


Phe Lys Lys Glu Xaa Glu Ala Ser Glu Ser Gly Leu Glu Ile His Xaa 
    530                 535                 540                 


Val Cys Ser Gln Lys Glu Asp Ser Leu Cys Pro Asn Leu Ile Asp Asn 
545                 550                 555                 560 


Gly Ser Trp Pro Ala Xaa Xaa Xaa Gln Asn Ser Val Ala Leu Lys Asn 
                565                 570                 575     


Ala Gly Leu Ile Ser Xaa Leu Lys Lys Lys Xaa Asn Lys Phe Ile Tyr 
            580                 585                 590         


Ala Ile His Asp Glu Xaa Ser Tyr Lys Gly Lys Lys Ile Pro Lys Asp 
        595                 600                 605             


Gln Lys Ser Glu Leu Ile Asn Cys Ser Ala Gln Phe Glu Ala Asn Ala 
    610                 615                 620                 


Phe Glu Ala Pro Leu Xaa Phe Ala Asn Ala Asp Ser Gly Leu Leu His 
625                 630                 635                 640 


Ser Ser Val Lys Arg Ser Cys Ser Gln Asn Asp Ser Glu Glu Pro Xaa 
                645                 650                 655     


Leu Ser Leu Xaa Ser Ser Phe Gly Xaa Ile Leu Arg Lys Cys Ser Arg 
            660                 665                 670         


Asn Glu Xaa Cys Ser Asn Asn Xaa Val Ile Ser Gln Asp Leu Asp Tyr 
        675                 680                 685             


Lys Glu Ala Lys Cys Asn Lys Glu Lys Leu Gln Leu Phe Ile Xaa Pro 
    690                 695                 700                 


Glu Ala Asp Ser Leu Ser Cys Leu Gln Glu Gly Gln Cys Glu Asn Asp 
705                 710                 715                 720 


Pro Lys Ser Lys Lys Val Ser Asp Ile Lys Glu Glu Val Leu Ala Ala 
                725                 730                 735     


Ala Cys His Pro Val Gln His Ser Lys Val Glu Tyr Ser Asp Xaa Asp 
            740                 745                 750         


Phe Gln Ser Gln Lys Ser Leu Leu Tyr Asp His Glu Asn Ala Ser Xaa 
        755                 760                 765             


Leu Ile Leu Xaa Pro Xaa Ser Lys Asp Val Leu Ser Asn Leu Val Met 
    770                 775                 780                 


Ile Ser Arg Gly Lys Glu Ser Tyr Lys Met Ser Asp Lys Leu Lys Gly 
785                 790                 795                 800 


Asn Asn Tyr Glu Ser Asp Val Glu Leu Xaa Lys Asn Ile Pro Met Glu 
                805                 810                 815     


Lys Asn Gln Asp Val Cys Ala Leu Asn Glu Asn Tyr Lys Asn Val Glu 
            820                 825                 830         


Leu Leu Pro Pro Glu Lys Tyr Met Arg Val Ala Ser Pro Ser Arg Lys 
        835                 840                 845             


Val Gln Phe Asn Gln Asn Xaa Asn Leu Arg Val Ile Gln Lys Asn Gln 
    850                 855                 860                 


Glu Glu Xaa Xaa Ser Ile Ser Lys Ile Xaa Val Asn Pro Asp Ser Glu 
865                 870                 875                 880 


Glu Leu Phe Ser Asp Asn Glu Asn Asn Phe Val Phe Gln Val Ala Asn 
                885                 890                 895     


Glu Arg Asn Asn Leu Ala Leu Gly Asn Xaa Lys Glu Leu His Glu Xaa 
            900                 905                 910         


Asp Leu Xaa Cys Val Asn Glu Pro Ile Phe Lys Asn Ser Xaa Met Val 
        915                 920                 925             


Leu Tyr Gly Asp Xaa Gly Asp Lys Gln Ala Xaa Gln Val Ser Ile Lys 
    930                 935                 940                 


Lys Asp Leu Val Tyr Val Leu Ala Glu Glu Asn Lys Asn Ser Val Lys 
945                 950                 955                 960 


Gln His Ile Lys Met Xaa Leu Gly Gln Asp Leu Lys Ser Asp Ile Ser 
                965                 970                 975     


Leu Asn Ile Asp Lys Ile Pro Glu Lys Asn Asn Asp Tyr Met Asn Lys 
            980                 985                 990         


Trp Ala Gly Leu Leu Gly Pro Ile  Ser Asn His Ser Phe  Gly Gly Ser 
        995                 1000                 1005             


Phe Arg  Xaa Ala Ser Asn Lys  Glu Ile Lys Leu Ser  Glu His Asn 
    1010                 1015                 1020             


Ile Lys  Lys Ser Lys Met Phe  Phe Lys Asp Ile Glu  Glu Gln Tyr 
    1025                 1030                 1035             


Pro Xaa  Ser Leu Ala Cys Val  Glu Ile Val Asn Xaa  Leu Ala Leu 
    1040                 1045                 1050             


Asp Asn  Gln Lys Lys Leu Ser  Lys Pro Gln Ser Ile  Asn Xaa Val 
    1055                 1060                 1065             


Ser Ala  His Leu Gln Ser Ser  Val Val Val Ser Asp  Cys Lys Asn 
    1070                 1075                 1080             


Ser His  Ile Xaa Pro Gln Met  Leu Phe Ser Lys Gln  Asp Phe Asn 
    1085                 1090                 1095             


Ser Asn  His Asn Leu Xaa Pro  Ser Gln Lys Ala Glu  Ile Xaa Glu 
    1100                 1105                 1110             


Leu Ser  Xaa Ile Leu Glu Glu  Ser Gly Ser Gln Phe  Glu Phe Xaa 
    1115                 1120                 1125             


Gln Phe  Arg Lys Pro Ser Tyr  Ile Leu Gln Lys Ser  Xaa Phe Glu 
    1130                 1135                 1140             


Val Pro  Glu Asn Gln Met Xaa  Ile Leu Lys Xaa Xaa  Ser Glu Glu 
    1145                 1150                 1155             


Cys Arg  Asp Ala Asp Leu His  Val Ile Met Asn Ala  Pro Ser Ile 
    1160                 1165                 1170             


Gly Gln  Val Asp Ser Ser Lys  Gln Phe Glu Gly Xaa  Val Glu Ile 
    1175                 1180                 1185             


Lys Arg  Lys Phe Ala Gly Leu  Leu Lys Asn Asp Cys  Asn Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Tyr Leu Xaa Asp  Glu Asn Glu Val Gly  Phe Arg Gly 
    1205                 1210                 1215             


Phe Tyr  Ser Ala His Gly Xaa  Lys Leu Asn Val Ser  Xaa Glu Ala 
    1220                 1225                 1230             


Leu Gln  Lys Ala Val Lys Leu  Phe Ser Asp Ile Glu  Asn Ile Ser 
    1235                 1240                 1245             


Glu Glu  Xaa Ser Ala Glu Val  His Pro Ile Ser Leu  Ser Ser Ser 
    1250                 1255                 1260             


Lys Cys  His Asp Ser Val Val  Ser Met Phe Lys Ile  Glu Asn His 
    1265                 1270                 1275             


Asn Asp  Lys Xaa Val Ser Glu  Lys Asn Asn Lys Cys  Gln Leu Ile 
    1280                 1285                 1290             


Leu Gln  Asn Asn Ile Glu Met  Xaa Xaa Gly Xaa Phe  Val Glu Glu 
    1295                 1300                 1305             


Ile Xaa  Glu Asn Tyr Lys Arg  Asn Xaa Glu Asn Glu  Asp Asn Lys 
    1310                 1315                 1320             


Tyr Xaa  Ala Ala Ser Arg Asn  Ser His Asn Leu Glu  Phe Asp Gly 
    1325                 1330                 1335             


Ser Asp  Ser Ser Lys Asn Asp  Xaa Val Cys Ile His  Lys Asp Glu 
    1340                 1345                 1350             


Xaa Asp  Leu Leu Phe Xaa Asp  Gln His Asn Ile Cys  Leu Lys Leu 
    1355                 1360                 1365             


Ser Gly  Gln Phe Met Lys Glu  Gly Asn Xaa Gln Ile  Lys Glu Asp 
    1370                 1375                 1380             


Leu Ser  Asp Leu Xaa Phe Leu  Glu Val Ala Lys Ala  Gln Glu Ala 
    1385                 1390                 1395             


Cys His  Gly Asn Xaa Ser Asn  Lys Glu Gln Leu Xaa  Ala Xaa Lys 
    1400                 1405                 1410             


Xaa Glu  Gln Asn Ile Lys Asp  Phe Glu Xaa Ser Asp  Xaa Phe Phe 
    1415                 1420                 1425             


Gln Xaa  Ala Ser Gly Lys Asn  Ile Ser Val Ala Lys  Glu Ser Phe 
    1430                 1435                 1440             


Asn Lys  Ile Val Asn Phe Phe  Asp Gln Lys Pro Glu  Glu Leu His 
    1445                 1450                 1455             


Asn Phe  Ser Leu Asn Ser Glu  Leu His Ser Asp Ile  Arg Lys Asn 
    1460                 1465                 1470             


Lys Met  Asp Ile Leu Ser Tyr  Glu Glu Xaa Asp Ile  Val Lys His 
    1475                 1480                 1485             


Lys Ile  Leu Lys Glu Ser Val  Pro Val Gly Xaa Gly  Asn Gln Leu 
    1490                 1495                 1500             


Val Xaa  Phe Gln Gly Gln Pro  Glu Arg Asp Glu Lys  Ile Lys Glu 
    1505                 1510                 1515             


Pro Xaa  Leu Leu Gly Phe His  Xaa Ala Ser Gly Lys  Lys Val Lys 
    1520                 1525                 1530             


Ile Ala  Lys Glu Ser Leu Asp  Lys Val Lys Asn Leu  Phe Asp Glu 
    1535                 1540                 1545             


Lys Glu  Gln Gly Xaa Ser Glu  Ile Xaa Ser Phe Ser  His Gln Trp 
    1550                 1555                 1560             


Ala Lys  Xaa Leu Lys Tyr Arg  Glu Ala Cys Lys Asp  Leu Glu Leu 
    1565                 1570                 1575             


Ala Cys  Glu Xaa Ile Glu Ile  Xaa Ala Ala Pro Lys  Cys Lys Glu 
    1580                 1585                 1590             


Met Gln  Asn Ser Leu Asn Asn  Asp Lys Asn Leu Val  Ser Ile Glu 
    1595                 1600                 1605             


Xaa Val  Val Pro Pro Lys Leu  Leu Ser Asp Asn Leu  Cys Arg Gln 
    1610                 1615                 1620             


Xaa Glu  Asn Leu Lys Xaa Ser  Lys Ser Ile Phe Leu  Lys Val Lys 
    1625                 1630                 1635             


Val His  Glu Asn Val Glu Lys  Glu Xaa Ala Lys Ser  Pro Ala Xaa 
    1640                 1645                 1650             


Cys Tyr  Xaa Asn Gln Ser Pro  Tyr Ser Val Ile Glu  Asn Ser Ala 
    1655                 1660                 1665             


Leu Ala  Phe Tyr Xaa Ser Cys  Ser Arg Lys Xaa Ser  Val Ser Gln 
    1670                 1675                 1680             


Xaa Ser  Leu Leu Glu Ala Lys  Lys Trp Leu Arg Glu  Gly Ile Phe 
    1685                 1690                 1695             


Asp Gly  Gln Pro Glu Arg Ile  Asn Xaa Ala Asp Tyr  Val Gly Asn 
    1700                 1705                 1710             


Tyr Leu  Tyr Glu Asn Asn Ser  Asn Ser Xaa Ile Ala  Glu Asn Asp 
    1715                 1720                 1725             


Lys Asn  His Leu Ser Glu Lys  Gln Asp Xaa Tyr Leu  Ser Asn Ser 
    1730                 1735                 1740             


Ser Met  Ser Asn Ser Tyr Ser  Tyr His Ser Asp Glu  Val Tyr Asn 
    1745                 1750                 1755             


Asp Ser  Gly Tyr Leu Ser Lys  Asn Lys Leu Asp Ser  Gly Ile Glu 
    1760                 1765                 1770             


Pro Val  Leu Lys Asn Val Glu  Asp Gln Lys Asn Xaa  Ser Phe Ser 
    1775                 1780                 1785             


Lys Val  Ile Ser Asn Val Lys  Asp Ala Asn Ala Tyr  Pro Gln Xaa 
    1790                 1795                 1800             


Val Asn  Glu Asp Ile Cys Val  Glu Glu Leu Val Xaa  Ser Ser Ser 
    1805                 1810                 1815             


Pro Cys  Lys Asn Lys Asn Ala  Ala Ile Lys Leu Ser  Ile Ser Asn 
    1820                 1825                 1830             


Ser Asn  Asn Phe Glu Val Gly  Pro Pro Ala Phe Arg  Ile Ala Ser 
    1835                 1840                 1845             


Gly Lys  Ile Val Cys Val Ser  His Glu Xaa Ile Lys  Lys Val Lys 
    1850                 1855                 1860             


Asp Ile  Phe Xaa Asp Ser Phe  Ser Lys Val Ile Lys  Glu Asn Asn 
    1865                 1870                 1875             


Glu Asn  Lys Ser Lys Ile Cys  Gln Xaa Lys Ile Met  Ala Gly Cys 
    1880                 1885                 1890             


Tyr Glu  Ala Leu Asp Asp Ser  Glu Asp Ile Leu His  Asn Ser Leu 
    1895                 1900                 1905             


Asp Asn  Asp Glu Cys Ser Xaa  His Ser His Lys Val  Phe Ala Asp 
    1910                 1915                 1920             


Ile Gln  Ser Glu Glu Ile Leu  Gln His Asn Gln Asn  Met Ser Gly 
    1925                 1930                 1935             


Leu Glu  Lys Val Ser Lys Ile  Ser Pro Cys Asp Val  Ser Leu Glu 
    1940                 1945                 1950             


Xaa Ser  Asp Ile Cys Lys Cys  Ser Ile Gly Lys Leu  His Lys Ser 
    1955                 1960                 1965             


Val Ser  Ser Ala Asn Xaa Cys  Gly Ile Phe Ser Xaa  Ala Ser Gly 
    1970                 1975                 1980             


Lys Ser  Val Gln Val Ser Asp  Ala Ser Leu Gln Asn  Ala Arg Gln 
    1985                 1990                 1995             


Val Phe  Ser Glu Ile Glu Asp  Ser Xaa Lys Gln Val  Phe Ser Lys 
    2000                 2005                 2010             


Val Leu  Phe Lys Ser Asn Glu  His Ser Asp Gln Leu  Xaa Arg Glu 
    2015                 2020                 2025             


Glu Asn  Xaa Ala Ile Arg Xaa  Pro Glu His Leu Ile  Ser Gln Lys 
    2030                 2035                 2040             


Gly Phe  Ser Tyr Asn Val Val  Asn Ser Ser Ala Phe  Ser Gly Phe 
    2045                 2050                 2055             


Ser Xaa  Ala Ser Gly Lys Gln  Val Ser Ile Leu Glu  Ser Ser Leu 
    2060                 2065                 2070             


His Lys  Val Lys Gly Val Leu  Glu Glu Phe Asp Leu  Ile Arg Xaa 
    2075                 2080                 2085             


Glu His  Ser Leu His Tyr Ser  Pro Xaa Ser Arg Gln  Asn Val Ser 
    2090                 2095                 2100             


Lys Ile  Leu Pro Arg Val Asp  Lys Arg Asn Pro Glu  His Cys Val 
    2105                 2110                 2115             


Asn Ser  Glu Met Glu Lys Xaa  Cys Ser Lys Glu Phe  Lys Leu Ser 
    2120                 2125                 2130             


Asn Asn  Leu Asn Val Glu Gly  Gly Ser Ser Glu Asn  Asn His Ser 
    2135                 2140                 2145             


Ile Lys  Val Ser Pro Tyr Leu  Ser Gln Phe Gln Gln  Asp Lys Gln 
    2150                 2155                 2160             


Gln Leu  Val Leu Gly Xaa Lys  Val Ser Leu Val Glu  Asn Ile His 
    2165                 2170                 2175             


Val Leu  Gly Lys Glu Gln Ala  Ser Pro Lys Asn Val  Lys Met Glu 
    2180                 2185                 2190             


Ile Gly  Lys Xaa Glu Xaa Phe  Ser Asp Val Pro Val  Lys Xaa Asn 
    2195                 2200                 2205             


Ile Glu  Val Cys Ser Xaa Tyr  Ser Lys Asp Ser Glu  Asn Tyr Phe 
    2210                 2215                 2220             


Glu Xaa  Glu Ala Val Glu Ile  Ala Lys Ala Phe Met  Glu Asp Asp 
    2225                 2230                 2235             


Glu Leu  Xaa Asp Ser Lys Leu  Pro Ser His Ala Xaa  His Ser Leu 
    2240                 2245                 2250             


Phe Xaa  Cys Pro Glu Asn Glu  Glu Met Val Leu Ser  Asn Ser Arg 
    2255                 2260                 2265             


Ile Gly  Lys Arg Arg Gly Glu  Pro Leu Ile Leu Val  Gly Glu Pro 
    2270                 2275                 2280             


Ser Ile  Lys Arg Asn Leu Leu  Asn Glu Phe Asp Arg  Ile Ile Glu 
    2285                 2290                 2295             


Asn Gln  Glu Lys Ser Leu Lys  Ala Ser Lys Ser Xaa  Pro Asp Gly 
    2300                 2305                 2310             


Xaa Ile  Lys Asp Arg Arg Leu  Phe Met His His Val  Ser Leu Glu 
    2315                 2320                 2325             


Pro Ile  Xaa Cys Val Pro Phe  Arg Xaa Xaa Lys Glu  Arg Gln Glu 
    2330                 2335                 2340             


Ile Gln  Asn Pro Asn Phe Xaa  Ala Pro Gly Gln Glu  Phe Leu Ser 
    2345                 2350                 2355             


Lys Ser  His Leu Tyr Glu His  Leu Xaa Leu Glu Lys  Ser Ser Ser 
    2360                 2365                 2370             


Asn Leu  Ala Val Ser Gly His  Pro Phe Tyr Gln Val  Ser Ala Xaa 
    2375                 2380                 2385             


Arg Asn  Glu Lys Met Arg His  Leu Ile Xaa Xaa Gly  Arg Pro Xaa 
    2390                 2395                 2400             


Lys Val  Phe Val Pro Pro Phe  Lys Xaa Lys Ser His  Phe His Arg 
    2405                 2410                 2415             


Val Glu  Gln Cys Val Arg Asn  Ile Asn Leu Glu Glu  Asn Arg Gln 
    2420                 2425                 2430             


Lys Gln  Asn Ile Asp Gly His  Gly Ser Asp Asp Ser  Lys Asn Lys 
    2435                 2440                 2445             


Ile Asn  Asp Asn Glu Ile His  Gln Phe Asn Lys Asn  Asn Ser Asn 
    2450                 2455                 2460             


Gln Ala  Val Ala Val Xaa Phe  Xaa Lys Cys Glu Glu  Glu Pro Leu 
    2465                 2470                 2475             


Asp Leu  Ile Xaa Ser Leu Gln  Asn Ala Arg Asp Ile  Gln Asp Met 
    2480                 2485                 2490             


Arg Ile  Lys Lys Lys Gln Arg  Gln Arg Val Phe Pro  Gln Pro Gly 
    2495                 2500                 2505             


Ser Leu  Tyr Leu Ala Lys Xaa  Ser Xaa Leu Pro Arg  Ile Ser Leu 
    2510                 2515                 2520             


Lys Ala  Ala Val Gly Gly Gln  Val Pro Ser Ala Cys  Ser His Lys 
    2525                 2530                 2535             


Gln Leu  Tyr Xaa Tyr Gly Val  Ser Lys His Cys Ile  Lys Ile Asn 
    2540                 2545                 2550             


Ser Lys  Asn Ala Glu Ser Phe  Gln Phe His Xaa Glu  Asp Tyr Phe 
    2555                 2560                 2565             


Gly Lys  Glu Ser Leu Trp Xaa  Gly Lys Gly Ile Gln  Leu Ala Asp 
    2570                 2575                 2580             


Gly Gly  Trp Leu Ile Pro Ser  Asn Asp Gly Lys Ala  Gly Lys Glu 
    2585                 2590                 2595             


Glu Phe  Tyr Arg Ala Leu Cys  Asp Xaa Pro Gly Val  Asp Pro Lys 
    2600                 2605                 2610             


Leu Ile  Ser Arg Ile Trp Val  Tyr Asn His Tyr Arg  Trp Ile Ile 
    2615                 2620                 2625             


Trp Lys  Leu Ala Ala Met Glu  Cys Ala Phe Pro Lys  Glu Phe Ala 
    2630                 2635                 2640             


Asn Arg  Cys Leu Ser Pro Glu  Arg Val Leu Leu Gln  Leu Lys Tyr 
    2645                 2650                 2655             


Arg Tyr  Asp Xaa Glu Ile Asp  Arg Ser Arg Arg Ser  Ala Ile Lys 
    2660                 2665                 2670             


Lys Ile  Met Glu Arg Asp Asp  Xaa Ala Ala Lys Xaa  Leu Val Leu 
    2675                 2680                 2685             


Cys Val  Ser Asp Ile Ile Ser  Leu Ser Ala Asn Ile  Ser Glu Xaa 
    2690                 2695                 2700             


Ser Ser  Asn Lys Xaa Ser Ser  Ala Asp Xaa Gln Lys  Val Ala Ile 
    2705                 2710                 2715             


Ile Glu  Leu Xaa Asp Gly Trp  Tyr Ala Val Lys Ala  Gln Leu Asp 
    2720                 2725                 2730             


Pro Pro  Leu Leu Ala Val Leu  Lys Asn Gly Arg Leu  Xaa Val Gly 
    2735                 2740                 2745             


Gln Lys  Ile Ile Leu His Gly  Ala Glu Leu Val Gly  Ser Pro Asp 
    2750                 2755                 2760             


Ala Cys  Xaa Pro Leu Glu Ala  Pro Glu Ser Leu Met  Leu Lys Ile 
    2765                 2770                 2775             


Ser Ala  Asn Ser Xaa Arg Pro  Ala Arg Trp Tyr Xaa  Lys Leu Gly 
    2780                 2785                 2790             


Phe Phe  Pro Asp Pro Arg Pro  Phe Pro Leu Pro Leu  Ser Ser Leu 
    2795                 2800                 2805             


Phe Ser  Asp Gly Gly Asn Val  Gly Cys Val Asp Val  Ile Ile Gln 
    2810                 2815                 2820             


Arg Ala  Tyr Pro Ile Gln Trp  Met Glu Lys Xaa Ser  Ser Gly Leu 
    2825                 2830                 2835             


Tyr Ile  Phe Arg Asn Glu Arg  Glu Glu Glu Lys Glu  Ala Ala Lys 
    2840                 2845                 2850             


Tyr Val  Glu Ala Gln Gln Lys  Arg Leu Glu Ala Leu  Phe Xaa Lys 
    2855                 2860                 2865             


Ile Gln  Glu Glu Phe Glu Glu  His Glu Glu Asn Xaa  Xaa Lys Pro 
    2870                 2875                 2880             


Tyr Leu  Pro Ser Arg Ala Leu  Xaa Arg Gln Gln Val  Arg Ala Leu 
    2885                 2890                 2895             


Gln Asp  Gly Ala Glu Leu Tyr  Glu Ala Val Lys Asn  Ala Ala Asp 
    2900                 2905                 2910             


Pro Ala  Tyr Leu Glu Gly Tyr  Phe Ser Glu Glu Gln  Leu Arg Ala 
    2915                 2920                 2925             


Leu Asn  Asn His Arg Gln Met  Leu Asn Asp Lys Lys  Gln Ala Gln 
    2930                 2935                 2940             


Ile Gln  Leu Glu Ile Arg Lys  Ala Met Glu Ser Ala  Glu Gln Lys 
    2945                 2950                 2955             


Glu Gln  Gly Leu Ser Arg Asp  Val Xaa Xaa Val Trp  Lys Leu Arg 
    2960                 2965                 2970             


Ile Val  Ser Tyr Ser Lys Lys  Glu Lys Asp Ser Val  Ile Leu Ser 
    2975                 2980                 2985             


Ile Trp  Arg Pro Ser Ser Asp  Leu Tyr Ser Leu Leu  Xaa Glu Gly 
    2990                 2995                 3000             


Lys Arg  Tyr Arg Ile Tyr His  Leu Ala Xaa Ser Lys  Ser Lys Ser 
    3005                 3010                 3015             


Lys Ser  Glu Arg Ala Asn Ile  Gln Leu Ala Ala Xaa  Lys Lys Xaa 
    3020                 3025                 3030             


Gln Tyr  Gln Gln Leu Pro Val  Ser Asp Glu Ile Leu  Phe Gln Ile 
    3035                 3040                 3045             


Tyr Gln  Pro Arg Glu Pro Leu  His Phe Ser Lys Phe  Leu Asp Pro 
    3050                 3055                 3060             


Asp Phe  Gln Pro Ser Cys Ser  Glu Val Asp Leu Ile  Gly Phe Val 
    3065                 3070                 3075             


Val Ser  Val Val Lys Lys Xaa  Gly Leu Ala Pro Phe  Val Tyr Leu 
    3080                 3085                 3090             


Ser Asp  Glu Cys Tyr Asn Leu  Leu Ala Ile Lys Phe  Trp Ile Asp 
    3095                 3100                 3105             


Leu Asn  Glu Asp Ile Ile Lys  Pro His Met Leu Ile  Ala Ala Ser 
    3110                 3115                 3120             


Asn Leu  Gln Trp Arg Pro Glu  Ser Lys Ser Gly Leu  Leu Xaa Leu 
    3125                 3130                 3135             


Phe Ala  Gly Asp Phe Ser Val  Phe Ser Ala Ser Pro  Lys Glu Gly 
    3140                 3145                 3150             


His Phe  Gln Glu Xaa Phe Asn  Lys Met Lys Asn Xaa  Val Glu Asn 
    3155                 3160                 3165             


Ile Asp  Ile Leu Cys Asn Glu  Ala Glu Asn Lys Leu  Met His Ile 
    3170                 3175                 3180             


Leu His  Ala Asn Asp Pro Lys  Trp Ser Xaa Pro Xaa  Lys Asp Cys 
    3185                 3190                 3195             


Xaa Ser  Gly Pro Tyr Xaa Ala  Gln Ile Ile Pro Gly  Xaa Gly Asn 
    3200                 3205                 3210             


Lys Leu  Leu Met Ser Ser Pro  Asn Cys Glu Ile Tyr  Tyr Gln Ser 
    3215                 3220                 3225             


Pro Leu  Ser Leu Cys Met Ala  Lys Arg Lys Ser Val  Ser Xaa Pro 
    3230                 3235                 3240             


Val Ser  Ala Gln Met Xaa Ser  Lys Ser Cys Lys Gly  Glu Lys Glu 
    3245                 3250                 3255             


Ile Asp  Asp Gln Lys Asn Cys  Lys Lys Arg Arg Ala  Leu Asp Phe 
    3260                 3265                 3270             


Leu Ser  Arg Leu Pro Leu Pro  Pro Pro Val Ser Pro  Ile Cys Xaa 
    3275                 3280                 3285             


Phe Val  Ser Pro Ala Ala Gln  Lys Ala Phe Gln Pro  Pro Arg Ser 
    3290                 3295                 3300             


Cys Gly  Xaa Lys Tyr Glu Xaa  Pro Ile Lys Lys Lys  Glu Leu Asn 
    3305                 3310                 3315             


Ser Pro  Gln Met Xaa Pro Phe  Lys Lys Phe Asn Glu  Ile Ser Leu 
    3320                 3325                 3330             


Leu Glu  Ser Asn Ser Ile Ala  Asp Glu Glu Leu Ala  Leu Ile Asn 
    3335                 3340                 3345             


Xaa Gln  Ala Leu Leu Ser Gly  Ser Xaa Gly Glu Lys  Gln Phe Ile 
    3350                 3355                 3360             


Ser Val  Ser Glu Ser Xaa Arg  Xaa Ala Pro Xaa Ser  Ser Glu Asp 
    3365                 3370                 3375             


Tyr Leu  Arg Leu Lys Arg Arg  Cys Xaa Xaa Ser Leu  Ile Lys Glu 
    3380                 3385                 3390             


Gln Glu  Ser Ser Gln Ala Ser  Xaa Glu Glu Cys Glu  Lys Asn Lys 
    3395                 3400                 3405             


Gln Asp  Xaa Ile Xaa Xaa Lys  Lys Tyr Ile 
    3410                 3415             


<210> 4376
<211> 64
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<400> 4376
Ser Ser Gly Leu Tyr Ile Phe Arg Asn Glu Arg Glu Glu Glu Lys Glu 
1               5                   10                  15      


Ala Ala Lys Tyr Val Glu Ala Gln Gln Lys Arg Leu Glu Ala Leu Phe 
            20                  25                  30          


Xaa Lys Ile Gln Glu Glu Phe Glu Glu His Glu Val Xaa Ser Ser Xaa 
        35                  40                  45              


Glu Val Leu Asn Pro Pro Lys Ser Ser Met Arg Val Gly Ile Asn Phe 
    50                  55                  60                  


<210> 4377
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 4377
Xaa Ser Lys Ser Lys Ser Glu Arg Ala Asn Ile Gln Leu Ala Ala Xaa 
1               5                   10                  15      


Lys Lys Xaa Gln Tyr Gln Gln Leu Pro Val Ser Asp Glu Ile Leu Phe 
            20                  25                  30          


Gln Ile Tyr Gln Pro Arg Glu Pro Leu His Phe Ser Lys Phe Leu Asp 
        35                  40                  45              


Pro Asp Phe Gln Pro Ser Cys Ser Glu Val Asp Leu Ile Gly Phe Val 
    50                  55                  60                  


Val Ser Val Val Lys Lys Xaa Gly Leu Ala Pro Phe Val Tyr Leu Ser 
65                  70                  75                  80  


Asp Glu Cys Tyr Asn Leu Leu Ala Ile Lys Phe Trp Ile Asp Leu Asn 
                85                  90                  95      


Glu Asp Ile Ile Lys Pro His Met Leu Ile Ala Ala Ser Asn Leu Gln 
            100                 105                 110         


Trp Arg Pro Glu Ser Lys Ser Gly Leu Leu Xaa Leu Phe Ala Gly Asp 
        115                 120                 125             


Phe Ser Val Phe Ser Ala Ser Pro Lys Glu Gly His Phe Gln Glu Xaa 
    130                 135                 140                 


Phe Asn Lys Met Lys Asn Xaa Val Glu Arg Gln Ser Leu Ala Leu Ser 
145                 150                 155                 160 


Pro Pro Gly Trp Ser Xaa Ile Ala Gln Ser Arg Ile Xaa Ala Val Ser 
                165                 170                 175     


Ala Ser Trp Ala Gln Ala Ile Leu Val Pro 
            180                 185     


<210> 4378
<211> 509
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(490)
<223> Selenocysteine

<400> 4378
Glu Leu Xaa Gly Gly Gly Xaa Xaa Phe Ser Val Arg Lys Xaa Ala Tyr 
1               5                   10                  15      


Cys Asp Val His Xaa Pro Pro Gly Cys Xaa Arg Arg Pro Leu Asn Ile 
            20                  25                  30          


Tyr Gly Asp Val Glu Met Lys Asn Gly Val Cys Arg Lys Glu Ser Ser 
        35                  40                  45              


Val Lys Xaa Val Arg Ser Xaa Ser Lys Val Arg Lys Lys Ala Lys Lys 
    50                  55                  60                  


Ala Lys Lys Ala Leu Ala Glu Pro Cys Ala Val Leu Pro Xaa Val Cys 
65                  70                  75                  80  


Ala Pro Tyr Ile Pro Pro Gln Arg Leu Asn Arg Ile Ala Asn Gln Val 
                85                  90                  95      


Ala Ile Gln Arg Lys Lys Gln Phe Val Glu Arg Ala His Ser Tyr Trp 
            100                 105                 110         


Leu Leu Lys Arg Leu Ser Arg Asn Gly Ala Pro Leu Leu Arg Arg Leu 
        115                 120                 125             


Gln Ser Ser Leu Gln Ser Gln Arg Ser Ser Gln Gln Arg Glu Asn Asp 
    130                 135                 140                 


Glu Glu Met Lys Ala Ala Lys Glu Lys Leu Lys Tyr Trp Gln Arg Leu 
145                 150                 155                 160 


Arg His Asp Leu Glu Arg Ala Arg Leu Leu Ile Glu Leu Leu Arg Lys 
                165                 170                 175     


Arg Glu Lys Leu Lys Arg Glu Gln Val Lys Val Glu Gln Val Ala Met 
            180                 185                 190         


Glu Leu Arg Leu Xaa Pro Leu Xaa Val Leu Leu Arg Ser Val Leu Asp 
        195                 200                 205             


Gln Leu Gln Asp Lys Asp Pro Ala Arg Ile Phe Ala Gln Pro Val Ser 
    210                 215                 220                 


Leu Lys Glu Val Pro Asp Tyr Leu Asp His Ile Lys His Pro Met Asp 
225                 230                 235                 240 


Phe Ala Xaa Met Arg Lys Arg Leu Glu Ala Gln Gly Tyr Lys Asn Leu 
                245                 250                 255     


His Glu Phe Glu Glu Asp Phe Asp Leu Ile Ile Asp Asn Cys Met Lys 
            260                 265                 270         


Tyr Asn Ala Arg Asp Xaa Val Phe Tyr Arg Ala Ala Val Arg Leu Arg 
        275                 280                 285             


Asp Gln Gly Gly Val Val Leu Arg Gln Ala Arg Arg Glu Val Asp Ser 
    290                 295                 300                 


Ile Gly Leu Glu Glu Ala Ser Gly Met His Leu Pro Glu Arg Pro Ala 
305                 310                 315                 320 


Ala Ala Pro Arg Arg Pro Phe Ser Trp Glu Asp Val Asp Arg Leu Leu 
                325                 330                 335     


Asp Pro Ala Asn Arg Ala His Leu Gly Leu Glu Glu Gln Leu Arg Glu 
            340                 345                 350         


Leu Leu Asp Met Leu Asp Leu Xaa Cys Ala Met Lys Ser Ser Gly Ser 
        355                 360                 365             


Arg Ser Lys Arg Ala Lys Leu Leu Lys Lys Glu Ile Ala Leu Leu Arg 
    370                 375                 380                 


Asn Lys Leu Ser Gln Gln His Ser Gln Pro Leu Pro Xaa Gly Pro Gly 
385                 390                 395                 400 


Leu Glu Gly Phe Glu Glu Asp Gly Ala Ala Leu Gly Pro Glu Ala Gly 
                405                 410                 415     


Glu Glu Ala Arg Asp Gln Asn Leu Phe Val Cys Ser Pro Ser Glu Val 
            420                 425                 430         


Gly Asp Ser Ser Ala Ala Lys Glu Lys Val Ala Glu His Met Arg Arg 
        435                 440                 445             


Leu Arg Gly Gly Gly Gly Val Pro Arg Lys Ala Pro Gly Arg Arg Ser 
    450                 455                 460                 


His Gln Arg Leu Trp Gly Cys Glu Glu Arg Ala Gly Ala Gly Arg Arg 
465                 470                 475                 480 


Pro Gly Glu Glu Gly His Xaa Pro Xaa Xaa Leu Cys Leu Arg Val Gln 
                485                 490                 495     


His Leu Leu Gln Gln Gln Pro Ala Leu Arg Leu Glu Leu 
            500                 505                 


<210> 4379
<211> 1189
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1145)..(1145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<400> 4379
Met Arg Arg Lys Gly Arg Cys His Arg Gly Ser Ala Ala Arg His Pro 
1               5                   10                  15      


Ser Ser Pro Cys Ser Val Lys His Ser Pro Xaa Arg Glu Xaa Leu Xaa 
            20                  25                  30          


Tyr Ala Gln Ala Gln Arg Met Val Glu Ile Glu Ile Glu Gly Arg Leu 
        35                  40                  45              


His Arg Ile Ser Ile Phe Asp Pro Leu Glu Ile Ile Leu Glu Asp Asp 
    50                  55                  60                  


Leu Xaa Ala Gln Glu Met Ser Glu Cys Asn Ser Asn Lys Glu Asn Ser 
65                  70                  75                  80  


Glu Arg Pro Pro Val Cys Leu Arg Xaa Lys Arg His Lys Asn Asn Arg 
                85                  90                  95      


Val Lys Lys Lys Asn Glu Ala Leu Pro Ser Ala His Gly Xaa Pro Ala 
            100                 105                 110         


Ser Ala Ser Ala Leu Pro Glu Pro Lys Val Arg Ile Val Glu Tyr Ser 
        115                 120                 125             


Pro Pro Ser Ala Pro Arg Arg Pro Pro Val Tyr Tyr Lys Phe Ile Glu 
    130                 135                 140                 


Lys Ser Ala Glu Glu Leu Asp Asn Glu Val Glu Tyr Asp Met Asp Glu 
145                 150                 155                 160 


Glu Asp Tyr Ala Trp Leu Glu Ile Val Asn Glu Lys Arg Lys Gly Asp 
                165                 170                 175     


Cys Val Pro Ala Val Ser Gln Ser Met Phe Glu Phe Leu Met Asp Arg 
            180                 185                 190         


Phe Glu Lys Glu Ser His Cys Glu Asn Gln Lys Gln Gly Glu Gln Gln 
        195                 200                 205             


Ser Leu Ile Asp Glu Asp Ala Val Cys Cys Ile Cys Met Asp Gly Glu 
    210                 215                 220                 


Cys Gln Asn Ser Asn Val Ile Leu Phe Cys Asp Met Cys Asn Leu Ala 
225                 230                 235                 240 


Val His Gln Glu Cys Tyr Gly Val Pro Tyr Ile Pro Glu Gly Gln Trp 
                245                 250                 255     


Leu Cys Arg His Cys Leu Gln Ser Arg Ala Arg Pro Ala Asp Cys Val 
            260                 265                 270         


Leu Cys Pro Asn Lys Gly Gly Ala Phe Lys Lys Xaa Asp Asp Asp Arg 
        275                 280                 285             


Trp Gly His Val Val Cys Ala Leu Trp Ile Pro Glu Val Gly Phe Ala 
    290                 295                 300                 


Asn Xaa Val Phe Ile Glu Pro Ile Asp Gly Val Arg Asn Ile Pro Pro 
305                 310                 315                 320 


Ala Arg Trp Lys Leu Xaa Cys Tyr Leu Cys Lys Gln Lys Gly Val Gly 
                325                 330                 335     


Ala Cys Ile Gln Cys His Lys Ala Asn Cys Tyr Xaa Ala Phe His Val 
            340                 345                 350         


Xaa Cys Ala Gln Lys Ala Gly Leu Tyr Met Lys Met Glu Pro Val Lys 
        355                 360                 365             


Glu Leu Xaa Gly Gly Gly Xaa Xaa Phe Ser Val Arg Lys Xaa Ala Tyr 
    370                 375                 380                 


Cys Asp Val His Xaa Pro Pro Gly Cys Xaa Arg Arg Pro Leu Asn Ile 
385                 390                 395                 400 


Tyr Gly Asp Val Glu Met Lys Asn Gly Val Cys Arg Lys Glu Ser Ser 
                405                 410                 415     


Val Lys Xaa Val Arg Ser Xaa Ser Lys Val Arg Lys Lys Ala Lys Lys 
            420                 425                 430         


Ala Lys Lys Ala Leu Ala Glu Pro Cys Ala Val Leu Pro Xaa Val Cys 
        435                 440                 445             


Ala Pro Tyr Ile Pro Pro Gln Arg Leu Asn Arg Ile Ala Asn Gln Val 
    450                 455                 460                 


Ala Ile Gln Arg Lys Lys Gln Phe Val Glu Arg Ala His Ser Tyr Trp 
465                 470                 475                 480 


Leu Leu Lys Arg Leu Ser Arg Asn Gly Ala Pro Leu Leu Arg Arg Leu 
                485                 490                 495     


Gln Ser Ser Leu Gln Ser Gln Arg Ser Ser Gln Gln Arg Glu Asn Asp 
            500                 505                 510         


Glu Glu Met Lys Ala Ala Lys Glu Lys Leu Lys Tyr Trp Gln Arg Leu 
        515                 520                 525             


Arg His Asp Leu Glu Arg Ala Arg Leu Leu Ile Glu Leu Leu Arg Lys 
    530                 535                 540                 


Arg Glu Lys Leu Lys Arg Glu Gln Val Lys Val Glu Gln Val Ala Met 
545                 550                 555                 560 


Glu Leu Arg Leu Xaa Pro Leu Xaa Val Leu Leu Arg Ser Val Leu Asp 
                565                 570                 575     


Gln Leu Gln Asp Lys Asp Pro Ala Arg Ile Phe Ala Gln Pro Val Ser 
            580                 585                 590         


Leu Lys Glu Val Pro Asp Tyr Leu Asp His Ile Lys His Pro Met Asp 
        595                 600                 605             


Phe Ala Xaa Met Arg Lys Arg Leu Glu Ala Gln Gly Tyr Lys Asn Leu 
    610                 615                 620                 


His Glu Phe Glu Glu Asp Phe Asp Leu Ile Ile Asp Asn Cys Met Lys 
625                 630                 635                 640 


Tyr Asn Ala Arg Asp Xaa Val Phe Tyr Arg Ala Ala Val Arg Leu Arg 
                645                 650                 655     


Asp Gln Gly Gly Val Val Leu Arg Gln Ala Arg Arg Glu Val Asp Ser 
            660                 665                 670         


Ile Gly Leu Glu Glu Ala Ser Gly Met His Leu Pro Glu Arg Pro Ala 
        675                 680                 685             


Ala Ala Pro Arg Arg Pro Phe Ser Trp Glu Asp Val Asp Arg Leu Leu 
    690                 695                 700                 


Asp Pro Ala Asn Arg Ala His Leu Gly Leu Glu Glu Gln Leu Arg Glu 
705                 710                 715                 720 


Leu Leu Asp Met Leu Asp Leu Xaa Cys Ala Met Lys Ser Ser Gly Ser 
                725                 730                 735     


Arg Ser Lys Arg Ala Lys Leu Leu Lys Lys Glu Ile Ala Leu Leu Arg 
            740                 745                 750         


Asn Lys Leu Ser Gln Gln His Ser Gln Pro Leu Pro Xaa Gly Pro Gly 
        755                 760                 765             


Leu Glu Gly Phe Glu Glu Asp Gly Ala Ala Leu Gly Pro Glu Ala Gly 
    770                 775                 780                 


Glu Glu Gly Asp Lys Ser Pro Pro Lys Leu Glu Pro Ser Asp Ala Leu 
785                 790                 795                 800 


Pro Leu Pro Ser Asn Ser Glu Xaa Asn Ser Glu Pro Pro Xaa Leu Lys 
                805                 810                 815     


Pro Val Glu Leu Asn Pro Glu Gln Ser Lys Leu Phe Lys Arg Val Xaa 
            820                 825                 830         


Phe Asp Asn Glu Ser His Ser Ala Cys Xaa Gln Ser Ala Leu Val Ser 
        835                 840                 845             


Gly Arg Pro Pro Glu Pro Xaa Arg Ala Ser Ser Gly Asp Val Pro Ala 
    850                 855                 860                 


Ala Ala Ala Ser Ala Val Ala Glu Pro Ala Ser Asp Val Asn Arg Arg 
865                 870                 875                 880 


Xaa Ser Val Leu Phe Cys Lys Ser Lys Ser Val Ser Pro Pro Lys Ser 
                885                 890                 895     


Ala Lys Asn Xaa Glu Xaa Gln Pro Xaa Ser Pro Gln Leu Gly Xaa Lys 
            900                 905                 910         


Xaa Phe Leu Ser Val Val Leu Pro Arg Leu Glu Xaa Leu Leu Gln Pro 
        915                 920                 925             


Arg Lys Arg Ser Arg Ser Xaa Cys Gly Asp Ser Glu Val Glu Glu Glu 
    930                 935                 940                 


Ser Pro Gly Lys Arg Leu Asp Ala Gly Leu Xaa Asn Gly Phe Gly Gly 
945                 950                 955                 960 


Ala Arg Ser Glu Gln Glu Pro Gly Gly Gly Leu Gly Arg Lys Ala Xaa 
                965                 970                 975     


Pro Arg Arg Arg Cys Ala Ser Glu Ser Ser Ile Ser Ser Ser Asn Ser 
            980                 985                 990         


Pro Leu Cys Asp Ser Ser Phe Asn  Ala Pro Lys Cys Gly  Arg Gly Lys 
        995                 1000                 1005             


Pro Ala  Leu Val Arg Arg His  Xaa Leu Glu Asp Arg  Ser Glu Leu 
    1010                 1015                 1020             


Ile Ser  Cys Ile Glu Asn Gly  Asn Tyr Ala Lys Ala  Ala Arg Ile 
    1025                 1030                 1035             


Ala Ala  Glu Val Gly Gln Ser  Ser Met Trp Ile Ser  Xaa Asp Ala 
    1040                 1045                 1050             


Ala Ala  Ser Val Leu Glu Pro  Leu Lys Val Val Trp  Ala Lys Cys 
    1055                 1060                 1065             


Ser Gly  Tyr Pro Ser Tyr Pro  Ala Leu Ile Ile Asp  Pro Lys Met 
    1070                 1075                 1080             


Pro Arg  Val Pro Gly His His  Asn Gly Val Xaa Ile  Pro Ala Pro 
    1085                 1090                 1095             


Pro Leu  Asp Val Leu Lys Ile  Gly Glu His Met Gln  Xaa Lys Ser 
    1100                 1105                 1110             


Asp Glu  Lys Leu Phe Leu Val  Leu Phe Phe Asp Asn  Lys Arg Ser 
    1115                 1120                 1125             


Trp Gln  Trp Leu Pro Lys Ser  Lys Met Val Pro Leu  Gly Ile Asp 
    1130                 1135                 1140             


Glu Xaa  Ile Asp Lys Leu Lys  Met Met Glu Gly Arg  Asn Ser Ser 
    1145                 1150                 1155             


Ile Arg  Lys Ala Val Arg Ile  Ala Phe Asp Arg Ala  Met Asn His 
    1160                 1165                 1170             


Leu Ser  Arg Val His Gly Glu  Pro Xaa Ser Asp Leu  Ser Asp Ile 
    1175                 1180                 1185             


Asp 
    


<210> 4380
<211> 1058
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<400> 4380
Met Arg Arg Lys Gly Arg Cys His Arg Gly Ser Ala Ala Arg His Pro 
1               5                   10                  15      


Ser Ser Pro Cys Ser Val Lys His Ser Pro Xaa Arg Glu Xaa Leu Xaa 
            20                  25                  30          


Tyr Ala Gln Ala Gln Arg Met Val Glu Ile Glu Ile Glu Gly Arg Leu 
        35                  40                  45              


His Arg Ile Ser Ile Phe Asp Pro Leu Glu Ile Ile Leu Glu Asp Asp 
    50                  55                  60                  


Leu Xaa Ala Gln Glu Met Ser Glu Cys Asn Ser Asn Lys Glu Asn Ser 
65                  70                  75                  80  


Glu Arg Pro Pro Val Cys Leu Arg Xaa Lys Arg His Lys Asn Asn Arg 
                85                  90                  95      


Val Lys Lys Lys Asn Glu Ala Leu Pro Ser Ala His Gly Xaa Pro Ala 
            100                 105                 110         


Ser Ala Ser Ala Leu Pro Glu Pro Lys Val Arg Ile Val Glu Tyr Ser 
        115                 120                 125             


Pro Pro Ser Ala Pro Arg Arg Pro Pro Val Tyr Tyr Lys Phe Ile Glu 
    130                 135                 140                 


Lys Ser Ala Glu Glu Leu Asp Asn Glu Val Glu Tyr Asp Met Asp Glu 
145                 150                 155                 160 


Glu Asp Tyr Ala Trp Leu Glu Ile Val Asn Glu Lys Arg Lys Gly Asp 
                165                 170                 175     


Cys Val Pro Ala Val Ser Gln Ser Met Phe Glu Phe Leu Met Asp Arg 
            180                 185                 190         


Phe Glu Lys Glu Ser His Cys Glu Asn Gln Lys Gln Gly Glu Gln Gln 
        195                 200                 205             


Ser Leu Ile Asp Glu Asp Ala Val Cys Cys Ile Cys Met Asp Gly Glu 
    210                 215                 220                 


Cys Gln Asn Ser Asn Val Ile Leu Phe Cys Asp Met Cys Asn Leu Ala 
225                 230                 235                 240 


Val His Gln Glu Cys Tyr Gly Val Pro Tyr Ile Pro Glu Gly Gln Trp 
                245                 250                 255     


Leu Cys Arg His Cys Leu Gln Ser Arg Ala Arg Pro Ala Asp Cys Val 
            260                 265                 270         


Leu Cys Pro Asn Lys Gly Gly Ala Phe Lys Lys Xaa Asp Asp Asp Arg 
        275                 280                 285             


Trp Gly His Val Val Cys Ala Leu Trp Ile Pro Glu Val Gly Phe Ala 
    290                 295                 300                 


Asn Xaa Val Phe Ile Glu Pro Ile Asp Gly Val Arg Asn Ile Pro Pro 
305                 310                 315                 320 


Ala Arg Trp Lys Leu Xaa Cys Tyr Leu Cys Lys Gln Lys Gly Val Gly 
                325                 330                 335     


Ala Cys Ile Gln Cys His Lys Ala Asn Cys Tyr Xaa Ala Phe His Val 
            340                 345                 350         


Xaa Cys Ala Gln Lys Ala Gly Leu Tyr Met Lys Met Glu Pro Val Lys 
        355                 360                 365             


Glu Leu Xaa Gly Gly Gly Xaa Xaa Phe Ser Val Arg Lys Xaa Ala Tyr 
    370                 375                 380                 


Cys Asp Val His Xaa Pro Pro Gly Cys Xaa Arg Arg Pro Leu Asn Ile 
385                 390                 395                 400 


Tyr Gly Asp Val Glu Met Lys Asn Gly Val Cys Arg Lys Glu Ser Ser 
                405                 410                 415     


Val Lys Xaa Val Arg Ser Xaa Ser Lys Val Arg Lys Lys Ala Lys Lys 
            420                 425                 430         


Ala Lys Lys Ala Leu Ala Glu Pro Cys Ala Val Leu Pro Xaa Val Cys 
        435                 440                 445             


Ala Pro Tyr Ile Pro Pro Gln Arg Leu Asn Arg Ile Ala Asn Gln Val 
    450                 455                 460                 


Ala Ile Gln Arg Lys Lys Gln Phe Val Glu Arg Ala His Ser Tyr Trp 
465                 470                 475                 480 


Leu Leu Lys Arg Leu Ser Arg Asn Gly Ala Pro Leu Leu Arg Arg Leu 
                485                 490                 495     


Gln Ser Ser Leu Gln Ser Gln Arg Ser Ser Gln Gln Arg Glu Asn Asp 
            500                 505                 510         


Glu Glu Met Lys Ala Ala Lys Glu Lys Leu Lys Tyr Trp Gln Arg Leu 
        515                 520                 525             


Arg His Asp Leu Glu Arg Ala Arg Leu Leu Ile Glu Leu Leu Arg Lys 
    530                 535                 540                 


Arg Glu Lys Leu Lys Arg Glu Gln Val Lys Val Glu Gln Val Ala Met 
545                 550                 555                 560 


Glu Leu Arg Leu Xaa Pro Leu Xaa Val Leu Leu Arg Ser Val Leu Asp 
                565                 570                 575     


Gln Leu Gln Asp Lys Asp Pro Ala Arg Ile Phe Ala Gln Pro Val Ser 
            580                 585                 590         


Leu Lys Glu Val Pro Asp Tyr Leu Asp His Ile Lys His Pro Met Asp 
        595                 600                 605             


Phe Ala Xaa Met Arg Lys Arg Leu Glu Ala Gln Gly Tyr Lys Asn Leu 
    610                 615                 620                 


His Glu Phe Glu Glu Asp Phe Asp Leu Ile Ile Asp Asn Cys Met Lys 
625                 630                 635                 640 


Tyr Asn Ala Arg Asp Xaa Val Phe Tyr Arg Ala Ala Val Arg Leu Arg 
                645                 650                 655     


Asp Gln Gly Gly Val Val Leu Arg Gln Ala Arg Arg Glu Val Asp Ser 
            660                 665                 670         


Ile Gly Leu Glu Glu Ala Ser Gly Met His Leu Pro Glu Arg Pro Ala 
        675                 680                 685             


Ala Ala Pro Arg Arg Pro Phe Ser Trp Glu Asp Val Asp Arg Leu Leu 
    690                 695                 700                 


Asp Pro Ala Asn Arg Ala His Leu Gly Leu Glu Glu Gln Leu Arg Glu 
705                 710                 715                 720 


Leu Leu Asp Met Leu Asp Leu Xaa Cys Ala Met Lys Ser Ser Gly Ser 
                725                 730                 735     


Arg Ser Lys Arg Ala Lys Leu Leu Lys Lys Glu Ile Ala Leu Leu Arg 
            740                 745                 750         


Asn Lys Leu Ser Gln Gln His Ser Gln Pro Leu Pro Xaa Gly Pro Gly 
        755                 760                 765             


Leu Glu Gly Phe Glu Glu Asp Gly Ala Ala Leu Gly Pro Glu Ala Gly 
    770                 775                 780                 


Glu Glu Val Leu Pro Arg Leu Glu Xaa Leu Leu Gln Pro Arg Lys Arg 
785                 790                 795                 800 


Ser Arg Ser Xaa Cys Gly Asp Ser Glu Val Glu Glu Glu Ser Pro Gly 
                805                 810                 815     


Lys Arg Leu Asp Ala Gly Leu Xaa Asn Gly Phe Gly Gly Ala Arg Ser 
            820                 825                 830         


Glu Gln Glu Pro Gly Gly Gly Leu Gly Arg Lys Ala Xaa Pro Arg Arg 
        835                 840                 845             


Arg Cys Ala Ser Glu Ser Ser Ile Ser Ser Ser Asn Ser Pro Leu Cys 
    850                 855                 860                 


Asp Ser Ser Phe Asn Ala Pro Lys Cys Gly Arg Gly Lys Pro Ala Leu 
865                 870                 875                 880 


Val Arg Arg His Xaa Leu Glu Asp Arg Ser Glu Leu Ile Ser Cys Ile 
                885                 890                 895     


Glu Asn Gly Asn Tyr Ala Lys Ala Ala Arg Ile Ala Ala Glu Val Gly 
            900                 905                 910         


Gln Ser Ser Met Trp Ile Ser Xaa Asp Ala Ala Ala Ser Val Leu Glu 
        915                 920                 925             


Pro Leu Lys Val Val Trp Ala Lys Cys Ser Gly Tyr Pro Ser Tyr Pro 
    930                 935                 940                 


Ala Leu Ile Ile Asp Pro Lys Met Pro Arg Val Pro Gly His His Asn 
945                 950                 955                 960 


Gly Val Xaa Ile Pro Ala Pro Pro Leu Asp Val Leu Lys Ile Gly Glu 
                965                 970                 975     


His Met Gln Xaa Lys Ser Asp Glu Lys Leu Phe Leu Val Leu Phe Phe 
            980                 985                 990         


Asp Asn Lys Arg Ser Trp Gln Trp  Leu Pro Lys Ser Lys  Met Val Pro 
        995                 1000                 1005             


Leu Gly  Ile Asp Glu Xaa Ile  Asp Lys Leu Lys Met  Met Glu Gly 
    1010                 1015                 1020             


Arg Asn  Ser Ser Ile Arg Lys  Ala Val Arg Ile Ala  Phe Asp Arg 
    1025                 1030                 1035             


Ala Met  Asn His Leu Ser Arg  Val His Gly Glu Pro  Xaa Ser Asp 
    1040                 1045                 1050             


Leu Ser  Asp Ile Asp 
    1055             


<210> 4381
<211> 20
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<400> 4381
Met Ser Xaa Ala Xaa Xaa Val Ala Pro Ala Gly Ile Pro Ala Xaa Pro 
1               5                   10                  15      


Gly Pro Val Asn 
            20  


<210> 4382
<211> 74
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<400> 4382
Met Ser Xaa Ala Xaa Xaa Val Ala Pro Ala Gly Ile Pro Ala Xaa Pro 
1               5                   10                  15      


Gly Pro Val Asn Pro Pro Pro Pro Glu Val Ser Asn Pro Ser Lys Pro 
            20                  25                  30          


Gly Arg Lys Xaa Asn Gln Leu Gln Tyr Met Gln Asn Val Val Val Lys 
        35                  40                  45              


Xaa Leu Trp Lys His Gln Phe Ala Trp Pro Phe Tyr Gln Pro Val Asp 
    50                  55                  60                  


Ala Ile Lys Leu Asn Leu Pro Asp Tyr His 
65                  70                  


<210> 4383
<211> 726
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(625)
<223> Selenocysteine

<400> 4383
Met Ser Xaa Ala Xaa Xaa Val Ala Pro Ala Gly Ile Pro Ala Xaa Pro 
1               5                   10                  15      


Gly Pro Val Asn Pro Pro Pro Pro Glu Val Ser Asn Pro Ser Lys Pro 
            20                  25                  30          


Gly Arg Lys Xaa Asn Gln Leu Gln Tyr Met Gln Asn Val Val Val Lys 
        35                  40                  45              


Xaa Leu Trp Lys His Gln Phe Ala Trp Pro Phe Tyr Gln Pro Val Asp 
    50                  55                  60                  


Ala Ile Lys Leu Asn Leu Pro Asp Tyr His Lys Ile Ile Lys Asn Pro 
65                  70                  75                  80  


Met Asp Met Gly Xaa Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp 
                85                  90                  95      


Ser Ala Ser Glu Cys Met Gln Asp Phe Asn Xaa Met Phe Xaa Asn Cys 
            100                 105                 110         


Tyr Ile Tyr Asn Lys Pro Xaa Asp Asp Ile Val Leu Met Ala Gln Ala 
        115                 120                 125             


Leu Glu Lys Ile Phe Leu Gln Lys Val Ala Gln Met Pro Gln Glu Glu 
    130                 135                 140                 


Val Glu Leu Leu Pro Pro Ala Pro Lys Gly Lys Gly Arg Lys Pro Ala 
145                 150                 155                 160 


Ala Gly Ala Gln Ser Ala Gly Xaa Gln Gln Val Ala Ala Val Ser Ser 
                165                 170                 175     


Val Ser Pro Ala Xaa Pro Phe Gln Ser Val Pro Pro Xaa Val Ser Gln 
            180                 185                 190         


Xaa Pro Val Ile Ala Ala Xaa Pro Val Pro Xaa Ile Xaa Ala Asn Val 
        195                 200                 205             


Xaa Ser Val Pro Val Pro Pro Ala Ala Ala Pro Pro Pro Pro Ala Xaa 
    210                 215                 220                 


Pro Ile Val Pro Val Val Pro Pro Xaa Pro Pro Val Val Lys Lys Lys 
225                 230                 235                 240 


Gly Val Lys Arg Lys Ala Asp Xaa Xaa Xaa Pro Xaa Xaa Ser Ala Ile 
                245                 250                 255     


Xaa Ala Ser Arg Ser Glu Ser Pro Pro Pro Leu Ser Asp Pro Lys Gln 
            260                 265                 270         


Ala Lys Val Val Ala Arg Arg Glu Ser Gly Gly Arg Pro Ile Lys Pro 
        275                 280                 285             


Pro Lys Lys Asp Leu Glu Asp Gly Glu Val Pro Gln His Ala Gly Lys 
    290                 295                 300                 


Lys Gly Lys Leu Ser Glu His Leu Arg Tyr Cys Asp Ser Ile Leu Arg 
305                 310                 315                 320 


Glu Met Leu Ser Lys Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys 
                325                 330                 335     


Pro Val Asp Ala Glu Ala Leu Glu Leu His Asp Tyr His Asp Ile Ile 
            340                 345                 350         


Lys His Pro Met Asp Leu Ser Xaa Val Lys Arg Lys Met Asp Gly Arg 
        355                 360                 365             


Glu Tyr Pro Asp Ala Gln Gly Phe Ala Ala Asp Val Arg Leu Met Phe 
    370                 375                 380                 


Ser Asn Cys Tyr Lys Tyr Asn Pro Pro Asp His Glu Val Val Ala Met 
385                 390                 395                 400 


Ala Arg Lys Leu Gln Asp Val Phe Glu Met Arg Phe Ala Lys Met Pro 
                405                 410                 415     


Asp Glu Pro Val Glu Ala Pro Ala Leu Pro Ala Pro Ala Ala Pro Met 
            420                 425                 430         


Val Ser Lys Gly Ala Glu Ser Ser Arg Ser Ser Glu Glu Ser Ser Ser 
        435                 440                 445             


Asp Ser Gly Ser Ser Asp Ser Glu Glu Glu Arg Ala Xaa Arg Leu Ala 
    450                 455                 460                 


Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu 
465                 470                 475                 480 


Ser Gln Ala Pro Val Asn Lys Pro Lys Lys Lys Lys Glu Lys Lys Glu 
                485                 490                 495     


Lys Glu Lys Lys Lys Lys Asp Lys Glu Lys Glu Lys Glu Lys His Lys 
            500                 505                 510         


Val Lys Ala Glu Glu Glu Lys Lys Ala Lys Val Ala Pro Pro Ala Lys 
        515                 520                 525             


Gln Ala Gln Gln Lys Lys Ala Pro Ala Lys Lys Ala Asn Ser Xaa Xaa 
    530                 535                 540                 


Xaa Ala Gly Arg Gln Leu Lys Lys Gly Gly Lys Gln Ala Ser Ala Ser 
545                 550                 555                 560 


Tyr Asp Ser Glu Glu Glu Glu Glu Gly Leu Pro Met Ser Tyr Asp Glu 
                565                 570                 575     


Lys Arg Gln Leu Ser Leu Asp Ile Asn Arg Leu Pro Gly Glu Lys Leu 
            580                 585                 590         


Gly Arg Val Val His Ile Ile Gln Ser Arg Glu Pro Ser Leu Arg Asp 
        595                 600                 605             


Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe Glu Xaa Leu Lys Pro Xaa 
    610                 615                 620                 


Xaa Leu Arg Glu Leu Glu Arg Tyr Val Lys Ser Cys Leu Gln Lys Lys 
625                 630                 635                 640 


Gln Arg Lys Pro Phe Ser Ala Ser Gly Lys Lys Gln Ala Ala Lys Ser 
                645                 650                 655     


Lys Glu Glu Leu Ala Gln Glu Lys Lys Lys Glu Leu Glu Lys Arg Leu 
            660                 665                 670         


Gln Asp Val Ser Gly Gln Leu Ser Ser Ser Lys Lys Pro Ala Arg Lys 
        675                 680                 685             


Glu Lys Pro Gly Ser Ala Pro Ser Gly Gly Pro Ser Arg Leu Ser Ser 
    690                 695                 700                 


Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Ser Ser Gly Ser Ser Ser 
705                 710                 715                 720 


Asp Ser Ser Asp Ser Glu 
                725     


<210> 4384
<211> 556
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<400> 4384
Met Ser Xaa Ala Xaa Xaa Val Ala Pro Ala Gly Ile Pro Ala Xaa Pro 
1               5                   10                  15      


Gly Pro Val Asn Pro Pro Pro Pro Glu Val Ser Asn Pro Ser Lys Pro 
            20                  25                  30          


Gly Arg Lys Xaa Asn Gln Leu Gln Tyr Met Gln Asn Val Val Val Lys 
        35                  40                  45              


Xaa Leu Trp Lys His Gln Phe Ala Trp Pro Phe Tyr Gln Pro Val Asp 
    50                  55                  60                  


Ala Ile Lys Leu Asn Leu Pro Asp Tyr His Lys Ile Ile Lys Asn Pro 
65                  70                  75                  80  


Met Asp Met Gly Xaa Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp 
                85                  90                  95      


Ser Ala Ser Glu Cys Met Gln Asp Phe Asn Xaa Met Phe Xaa Asn Cys 
            100                 105                 110         


Tyr Ile Tyr Asn Lys Pro Xaa Asp Asp Ile Val Leu Met Ala Gln Ala 
        115                 120                 125             


Leu Glu Lys Ile Phe Leu Gln Lys Val Ala Gln Met Pro Gln Glu Glu 
    130                 135                 140                 


Val Glu Leu Leu Pro Pro Ala Pro Lys Gly Lys Gly Arg Lys Pro Ala 
145                 150                 155                 160 


Ala Gly Ala Gln Ser Ala Gly Xaa Gln Gln Val Ala Ala Val Ser Ser 
                165                 170                 175     


Val Ser Pro Ala Xaa Pro Phe Gln Ser Val Pro Pro Xaa Val Ser Gln 
            180                 185                 190         


Xaa Pro Val Ile Ala Ala Xaa Pro Val Pro Xaa Ile Xaa Ala Asn Val 
        195                 200                 205             


Xaa Ser Val Pro Val Pro Pro Ala Ala Ala Pro Pro Pro Pro Ala Xaa 
    210                 215                 220                 


Pro Ile Val Pro Val Val Pro Pro Xaa Pro Pro Val Val Lys Lys Lys 
225                 230                 235                 240 


Gly Val Lys Arg Lys Ala Asp Xaa Xaa Xaa Pro Xaa Xaa Ser Ala Ile 
                245                 250                 255     


Xaa Ala Ser Arg Ser Glu Ser Pro Pro Pro Leu Ser Asp Pro Lys Gln 
            260                 265                 270         


Ala Lys Val Val Ala Arg Arg Glu Ser Gly Gly Arg Pro Ile Lys Pro 
        275                 280                 285             


Pro Lys Lys Asp Leu Glu Asp Gly Glu Val Pro Gln His Ala Gly Lys 
    290                 295                 300                 


Lys Gly Lys Leu Ser Glu His Leu Arg Tyr Cys Asp Ser Ile Leu Arg 
305                 310                 315                 320 


Glu Met Leu Ser Lys Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys 
                325                 330                 335     


Pro Val Asp Ala Glu Ala Leu Glu Leu His Asp Tyr His Asp Ile Ile 
            340                 345                 350         


Lys His Pro Met Asp Leu Ser Xaa Val Lys Arg Lys Met Asp Gly Arg 
        355                 360                 365             


Glu Tyr Pro Asp Ala Gln Gly Phe Ala Ala Asp Val Arg Leu Met Phe 
    370                 375                 380                 


Ser Asn Cys Tyr Lys Tyr Asn Pro Pro Asp His Glu Val Val Ala Met 
385                 390                 395                 400 


Ala Arg Lys Leu Gln Asp Val Phe Glu Met Arg Phe Ala Lys Met Pro 
                405                 410                 415     


Asp Glu Pro Val Glu Ala Pro Ala Leu Pro Ala Pro Ala Ala Pro Met 
            420                 425                 430         


Val Ser Lys Gly Ala Glu Ser Ser Arg Ser Ser Glu Glu Ser Ser Ser 
        435                 440                 445             


Asp Ser Gly Ser Ser Asp Ser Glu Glu Glu Arg Ala Xaa Arg Leu Ala 
    450                 455                 460                 


Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu 
465                 470                 475                 480 


Ser Gln Ala Pro Val Asn Lys Pro Lys Lys Lys Lys Glu Lys Lys Glu 
                485                 490                 495     


Lys Glu Lys Lys Lys Lys Asp Lys Glu Lys Glu Lys Glu Lys His Lys 
            500                 505                 510         


Val Lys Ala Glu Glu Glu Lys Lys Ala Lys Val Ala Pro Pro Ala Lys 
        515                 520                 525             


Gln Ala Gln Gln Lys Lys Ala Pro Ala Lys Lys Ala Asn Ser Xaa Xaa 
    530                 535                 540                 


Xaa Ala Gly Arg Asp His Phe Leu Xaa Cys Gly Val 
545                 550                 555     


<210> 4385
<211> 105
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 4385
Met Ser Ala Glu Ser Gly Pro Gly Xaa Arg Leu Arg Asn Leu Pro Val 
1               5                   10                  15      


Met Gly Asp Gly Leu Glu Xaa Ser Gln Met Ser Xaa Xaa Gln Ala Gln 
            20                  25                  30          


Ala Gln Pro Gln Pro Ala Asn Ala Ala Ser Xaa Asn Pro Pro Pro Pro 
        35                  40                  45              


Glu Xaa Ser Asn Pro Asn Lys Pro Lys Arg Gln Xaa Asn Gln Leu Gln 
    50                  55                  60                  


Tyr Leu Leu Arg Val Val Leu Lys Xaa Leu Trp Lys His Gln Phe Ala 
65                  70                  75                  80  


Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp 
                85                  90                  95      


Tyr Tyr Lys Ile Ile Lys Xaa Pro Met 
            100                 105 


<210> 4386
<211> 146
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<400> 4386
Met Ser Ala Glu Ser Gly Pro Gly Xaa Arg Leu Arg Asn Leu Pro Val 
1               5                   10                  15      


Met Gly Asp Gly Leu Glu Xaa Ser Gln Met Ser Xaa Xaa Gln Ala Gln 
            20                  25                  30          


Ala Gln Pro Gln Pro Ala Asn Ala Ala Ser Xaa Asn Pro Pro Pro Pro 
        35                  40                  45              


Glu Xaa Ser Asn Pro Asn Lys Pro Lys Arg Gln Xaa Asn Gln Leu Gln 
    50                  55                  60                  


Tyr Leu Leu Arg Val Val Leu Lys Xaa Leu Trp Lys His Gln Phe Ala 
65                  70                  75                  80  


Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp 
                85                  90                  95      


Tyr Tyr Lys Ile Ile Lys Xaa Pro Met Asp Met Gly Xaa Ile Lys Lys 
            100                 105                 110         


Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp 
        115                 120                 125             


Phe Asn Xaa Met Phe Xaa Asn Cys Tyr Ile Tyr Asn Lys Phe Arg Pro 
    130                 135                 140                 


Gln Met 
145     


<210> 4387
<211> 572
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<400> 4387
Met Ser Ala Glu Ser Gly Pro Gly Xaa Arg Leu Arg Asn Leu Pro Val 
1               5                   10                  15      


Met Gly Asp Gly Leu Glu Xaa Ser Gln Met Ser Xaa Xaa Gln Ala Gln 
            20                  25                  30          


Ala Gln Pro Gln Pro Ala Asn Ala Ala Ser Xaa Asn Pro Pro Pro Pro 
        35                  40                  45              


Glu Xaa Ser Asn Pro Asn Lys Pro Lys Arg Gln Xaa Asn Gln Leu Gln 
    50                  55                  60                  


Tyr Leu Leu Arg Val Val Leu Lys Xaa Leu Trp Lys His Gln Phe Ala 
65                  70                  75                  80  


Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp 
                85                  90                  95      


Tyr Tyr Lys Ile Ile Lys Xaa Pro Met Asp Met Gly Xaa Ile Lys Lys 
            100                 105                 110         


Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp 
        115                 120                 125             


Phe Asn Xaa Met Phe Xaa Asn Cys Tyr Ile Tyr Asn Lys Pro Gly Asp 
    130                 135                 140                 


Asp Ile Val Leu Met Ala Glu Ala Leu Glu Lys Leu Phe Leu Gln Lys 
145                 150                 155                 160 


Ile Asn Glu Leu Pro Xaa Glu Glu Xaa Glu Ile Met Ile Val Gln Ala 
                165                 170                 175     


Lys Gly Arg Gly Arg Gly Arg Lys Glu Xaa Gly Xaa Ala Lys Pro Gly 
            180                 185                 190         


Val Ser Xaa Val Pro Asn Xaa Xaa Gln Ala Ser Xaa Pro Pro Gln Xaa 
        195                 200                 205             


Gln Xaa Pro Gln Pro Asn Pro Pro Pro Val Gln Ala Xaa Pro His Pro 
    210                 215                 220                 


Phe Pro Ala Val Xaa Pro Asp Leu Ile Val Gln Xaa Pro Val Met Xaa 
225                 230                 235                 240 


Val Val Pro Pro Gln Pro Leu Gln Xaa Pro Pro Pro Val Pro Pro Gln 
                245                 250                 255     


Pro Gln Pro Pro Pro Ala Pro Ala Pro Gln Pro Val Gln Ser His Pro 
            260                 265                 270         


Pro Ile Ile Ala Ala Xaa Pro Gln Pro Val Lys Xaa Lys Lys Gly Val 
        275                 280                 285             


Lys Arg Lys Ala Asp Xaa Xaa Xaa Pro Xaa Xaa Ile Asp Pro Ile His 
    290                 295                 300                 


Glu Pro Pro Ser Leu Pro Pro Glu Pro Lys Xaa Xaa Lys Leu Gly Gln 
305                 310                 315                 320 


Arg Arg Glu Ser Ser Arg Pro Val Lys Pro Pro Lys Lys Asp Val Pro 
                325                 330                 335     


Asp Ser Gln Gln His Pro Ala Pro Glu Lys Ser Ser Lys Val Ser Glu 
            340                 345                 350         


Gln Leu Lys Cys Cys Ser Gly Ile Leu Lys Glu Met Phe Ala Lys Lys 
        355                 360                 365             


His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Val Glu Ala 
    370                 375                 380                 


Leu Gly Leu His Asp Tyr Cys Asp Ile Ile Lys His Pro Met Asp Met 
385                 390                 395                 400 


Ser Xaa Ile Lys Ser Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala Gln 
                405                 410                 415     


Glu Phe Gly Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr 
            420                 425                 430         


Asn Pro Pro Asp His Glu Val Val Ala Met Ala Arg Lys Leu Gln Asp 
        435                 440                 445             


Val Phe Glu Met Arg Phe Ala Lys Met Pro Asp Glu Pro Glu Glu Pro 
    450                 455                 460                 


Val Val Ala Val Ser Ser Pro Ala Val Pro Pro Pro Xaa Lys Val Val 
465                 470                 475                 480 


Ala Pro Pro Ser Ser Ser Asp Ser Ser Ser Asp Ser Ser Ser Asp Ser 
                485                 490                 495     


Asp Ser Ser Xaa Asp Asp Ser Glu Glu Glu Arg Ala Gln Arg Leu Ala 
            500                 505                 510         


Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu 
        515                 520                 525             


Ser Gln Pro Gln Gln Asn Lys Pro Lys Lys Lys Glu Lys Asp Lys Lys 
    530                 535                 540                 


Glu Lys Lys Lys Glu Lys His Lys Arg Lys Glu Glu Val Glu Glu Asn 
545                 550                 555                 560 


Lys Lys Ser Lys Ala Lys Glu Pro Pro Pro Lys Lys 
                565                 570         


<210> 4388
<211> 722
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<400> 4388
Met Ser Ala Glu Ser Gly Pro Gly Xaa Arg Leu Arg Asn Leu Pro Val 
1               5                   10                  15      


Met Gly Asp Gly Leu Glu Xaa Ser Gln Met Ser Xaa Xaa Gln Ala Gln 
            20                  25                  30          


Ala Gln Pro Gln Pro Ala Asn Ala Ala Ser Xaa Asn Pro Pro Pro Pro 
        35                  40                  45              


Glu Xaa Ser Asn Pro Asn Lys Pro Lys Arg Gln Xaa Asn Gln Leu Gln 
    50                  55                  60                  


Tyr Leu Leu Arg Val Val Leu Lys Xaa Leu Trp Lys His Gln Phe Ala 
65                  70                  75                  80  


Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp 
                85                  90                  95      


Tyr Tyr Lys Ile Ile Lys Xaa Pro Met Asp Met Gly Xaa Ile Lys Lys 
            100                 105                 110         


Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp 
        115                 120                 125             


Phe Asn Xaa Met Phe Xaa Asn Cys Tyr Ile Tyr Asn Lys Pro Gly Asp 
    130                 135                 140                 


Asp Ile Val Leu Met Ala Glu Ala Leu Glu Lys Leu Phe Leu Gln Lys 
145                 150                 155                 160 


Ile Asn Glu Leu Pro Xaa Glu Glu Xaa Glu Ile Met Ile Val Gln Ala 
                165                 170                 175     


Lys Gly Arg Gly Arg Gly Arg Lys Glu Xaa Gly Xaa Ala Lys Pro Gly 
            180                 185                 190         


Val Ser Xaa Val Pro Asn Xaa Xaa Gln Ala Ser Xaa Pro Pro Gln Xaa 
        195                 200                 205             


Gln Xaa Pro Gln Pro Asn Pro Pro Pro Val Gln Ala Xaa Pro His Pro 
    210                 215                 220                 


Phe Pro Ala Val Xaa Pro Asp Leu Ile Val Gln Xaa Pro Val Met Xaa 
225                 230                 235                 240 


Val Val Pro Pro Gln Pro Leu Gln Xaa Pro Pro Pro Val Pro Pro Gln 
                245                 250                 255     


Pro Gln Pro Pro Pro Ala Pro Ala Pro Gln Pro Val Gln Ser His Pro 
            260                 265                 270         


Pro Ile Ile Ala Ala Xaa Pro Gln Pro Val Lys Xaa Lys Lys Gly Val 
        275                 280                 285             


Lys Arg Lys Ala Asp Xaa Xaa Xaa Pro Xaa Xaa Ile Asp Pro Ile His 
    290                 295                 300                 


Glu Pro Pro Ser Leu Pro Pro Glu Pro Lys Xaa Xaa Lys Leu Gly Gln 
305                 310                 315                 320 


Arg Arg Glu Ser Ser Arg Pro Val Lys Pro Pro Lys Lys Asp Val Pro 
                325                 330                 335     


Asp Ser Gln Gln His Pro Ala Pro Glu Lys Ser Ser Lys Val Ser Glu 
            340                 345                 350         


Gln Leu Lys Cys Cys Ser Gly Ile Leu Lys Glu Met Phe Ala Lys Lys 
        355                 360                 365             


His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Val Glu Ala 
    370                 375                 380                 


Leu Gly Leu His Asp Tyr Cys Asp Ile Ile Lys His Pro Met Asp Met 
385                 390                 395                 400 


Ser Xaa Ile Lys Ser Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala Gln 
                405                 410                 415     


Glu Phe Gly Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr 
            420                 425                 430         


Asn Pro Pro Asp His Glu Val Val Ala Met Ala Arg Lys Leu Gln Asp 
        435                 440                 445             


Val Phe Glu Met Arg Phe Ala Lys Met Pro Asp Glu Pro Glu Glu Pro 
    450                 455                 460                 


Val Val Ala Val Ser Ser Pro Ala Val Pro Pro Pro Xaa Lys Val Val 
465                 470                 475                 480 


Ala Pro Pro Ser Ser Ser Asp Ser Ser Ser Asp Ser Ser Ser Asp Ser 
                485                 490                 495     


Asp Ser Ser Xaa Asp Asp Ser Glu Glu Glu Arg Ala Gln Arg Leu Ala 
            500                 505                 510         


Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu 
        515                 520                 525             


Ser Gln Pro Gln Gln Asn Lys Pro Lys Lys Lys Glu Lys Asp Lys Lys 
    530                 535                 540                 


Glu Lys Lys Lys Glu Lys His Lys Arg Lys Glu Glu Val Glu Glu Asn 
545                 550                 555                 560 


Lys Lys Ser Lys Ala Lys Glu Pro Pro Pro Lys Lys Xaa Lys Lys Asn 
                565                 570                 575     


Asn Ser Ser Asn Ser Asn Val Ser Lys Lys Glu Pro Ala Pro Met Lys 
            580                 585                 590         


Ser Lys Pro Pro Pro Xaa Tyr Glu Ser Glu Glu Glu Asp Lys Cys Lys 
        595                 600                 605             


Pro Met Ser Tyr Glu Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys 
    610                 615                 620                 


Leu Pro Gly Glu Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg 
625                 630                 635                 640 


Glu Pro Ser Leu Lys Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe 
                645                 650                 655     


Glu Xaa Leu Lys Pro Ser Xaa Leu Arg Glu Leu Glu Arg Tyr Val Xaa 
            660                 665                 670         


Ser Cys Leu Arg Lys Lys Arg Lys Pro Gln Ala Glu Lys Val Asp Val 
        675                 680                 685             


Ile Ala Gly Ser Ser Lys Met Lys Gly Phe Ser Ser Ser Glu Ser Glu 
    690                 695                 700                 


Ser Ser Ser Glu Ser Ser Ser Ser Asp Ser Glu Asp Ser Glu Xaa Gly 
705                 710                 715                 720 


Pro Ala 
        


<210> 4389
<211> 794
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<400> 4389
Met Ser Ala Glu Ser Gly Pro Gly Xaa Arg Leu Arg Asn Leu Pro Val 
1               5                   10                  15      


Met Gly Asp Gly Leu Glu Xaa Ser Gln Met Ser Xaa Xaa Gln Ala Gln 
            20                  25                  30          


Ala Gln Pro Gln Pro Ala Asn Ala Ala Ser Xaa Asn Pro Pro Pro Pro 
        35                  40                  45              


Glu Xaa Ser Asn Pro Asn Lys Pro Lys Arg Gln Xaa Asn Gln Leu Gln 
    50                  55                  60                  


Tyr Leu Leu Arg Val Val Leu Lys Xaa Leu Trp Lys His Gln Phe Ala 
65                  70                  75                  80  


Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp 
                85                  90                  95      


Tyr Tyr Lys Ile Ile Lys Xaa Pro Met Asp Met Gly Xaa Ile Lys Lys 
            100                 105                 110         


Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp 
        115                 120                 125             


Phe Asn Xaa Met Phe Xaa Asn Cys Tyr Ile Tyr Asn Lys Pro Gly Asp 
    130                 135                 140                 


Asp Ile Val Leu Met Ala Glu Ala Leu Glu Lys Leu Phe Leu Gln Lys 
145                 150                 155                 160 


Ile Asn Glu Leu Pro Xaa Glu Glu Xaa Glu Ile Met Ile Val Gln Ala 
                165                 170                 175     


Lys Gly Arg Gly Arg Gly Arg Lys Glu Xaa Gly Xaa Ala Lys Pro Gly 
            180                 185                 190         


Val Ser Xaa Val Pro Asn Xaa Xaa Gln Ala Ser Xaa Pro Pro Gln Xaa 
        195                 200                 205             


Gln Xaa Pro Gln Pro Asn Pro Pro Pro Val Gln Ala Xaa Pro His Pro 
    210                 215                 220                 


Phe Pro Ala Val Xaa Pro Asp Leu Ile Val Gln Xaa Pro Val Met Xaa 
225                 230                 235                 240 


Val Val Pro Pro Gln Pro Leu Gln Xaa Pro Pro Pro Val Pro Pro Gln 
                245                 250                 255     


Pro Gln Pro Pro Pro Ala Pro Ala Pro Gln Pro Val Gln Ser His Pro 
            260                 265                 270         


Pro Ile Ile Ala Ala Xaa Pro Gln Pro Val Lys Xaa Lys Lys Gly Val 
        275                 280                 285             


Lys Arg Lys Ala Asp Xaa Xaa Xaa Pro Xaa Xaa Ile Asp Pro Ile His 
    290                 295                 300                 


Glu Pro Pro Ser Leu Pro Pro Glu Pro Lys Xaa Xaa Lys Leu Gly Gln 
305                 310                 315                 320 


Arg Arg Glu Ser Ser Arg Pro Val Lys Pro Pro Lys Lys Asp Val Pro 
                325                 330                 335     


Asp Ser Gln Gln His Pro Ala Pro Glu Lys Ser Ser Lys Val Ser Glu 
            340                 345                 350         


Gln Leu Lys Cys Cys Ser Gly Ile Leu Lys Glu Met Phe Ala Lys Lys 
        355                 360                 365             


His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Val Glu Ala 
    370                 375                 380                 


Leu Gly Leu His Asp Tyr Cys Asp Ile Ile Lys His Pro Met Asp Met 
385                 390                 395                 400 


Ser Xaa Ile Lys Ser Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala Gln 
                405                 410                 415     


Glu Phe Gly Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr 
            420                 425                 430         


Asn Pro Pro Asp His Glu Val Val Ala Met Ala Arg Lys Leu Gln Asp 
        435                 440                 445             


Val Phe Glu Met Arg Phe Ala Lys Met Pro Asp Glu Pro Glu Glu Pro 
    450                 455                 460                 


Val Val Ala Val Ser Ser Pro Ala Val Pro Pro Pro Xaa Lys Val Val 
465                 470                 475                 480 


Ala Pro Pro Ser Ser Ser Asp Ser Ser Ser Asp Ser Ser Ser Asp Ser 
                485                 490                 495     


Asp Ser Ser Xaa Asp Asp Ser Glu Glu Glu Arg Ala Gln Arg Leu Ala 
            500                 505                 510         


Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu 
        515                 520                 525             


Ser Gln Pro Gln Gln Asn Lys Pro Lys Lys Lys Glu Lys Asp Lys Lys 
    530                 535                 540                 


Glu Lys Lys Lys Glu Lys His Lys Arg Lys Glu Glu Val Glu Glu Asn 
545                 550                 555                 560 


Lys Lys Ser Lys Ala Lys Glu Pro Pro Pro Lys Lys Xaa Lys Lys Asn 
                565                 570                 575     


Asn Ser Ser Asn Ser Asn Val Ser Lys Lys Glu Pro Ala Pro Met Lys 
            580                 585                 590         


Ser Lys Pro Pro Pro Xaa Tyr Glu Ser Glu Glu Glu Asp Lys Cys Lys 
        595                 600                 605             


Pro Met Ser Tyr Glu Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys 
    610                 615                 620                 


Leu Pro Gly Glu Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg 
625                 630                 635                 640 


Glu Pro Ser Leu Lys Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe 
                645                 650                 655     


Glu Xaa Leu Lys Pro Ser Xaa Leu Arg Glu Leu Glu Arg Tyr Val Xaa 
            660                 665                 670         


Ser Cys Leu Arg Lys Lys Arg Lys Pro Gln Ala Glu Lys Val Asp Val 
        675                 680                 685             


Ile Ala Gly Ser Ser Lys Met Lys Gly Phe Ser Ser Ser Glu Ser Glu 
    690                 695                 700                 


Ser Ser Ser Glu Ser Ser Ser Ser Asp Ser Glu Asp Ser Glu Xaa Ala 
705                 710                 715                 720 


Phe Cys Xaa Ser Gly Asp Phe Val Ser Pro Gly Pro Ser Pro Tyr His 
                725                 730                 735     


Ser His Val Gln Cys Gly Arg Phe Arg Glu Met Leu Arg Trp Phe Leu 
            740                 745                 750         


Val Asp Val Glu Gln Xaa Ala Ala Gly Gln Pro His Arg Gln Ser Ala 
        755                 760                 765             


Ala Gly Pro Ala Ile Xaa Trp Ala Pro Ala Ile Ala Tyr Pro Ser Pro 
    770                 775                 780                 


Glu Cys Ala Arg Cys Cys Val Gly Cys Ser 
785                 790                 


<210> 4390
<211> 1362
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1211)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1344)..(1344)
<223> Selenocysteine

<400> 4390
Met Ser Ala Glu Ser Gly Pro Gly Xaa Arg Leu Arg Asn Leu Pro Val 
1               5                   10                  15      


Met Gly Asp Gly Leu Glu Xaa Ser Gln Met Ser Xaa Xaa Gln Ala Gln 
            20                  25                  30          


Ala Gln Pro Gln Pro Ala Asn Ala Ala Ser Xaa Asn Pro Pro Pro Pro 
        35                  40                  45              


Glu Xaa Ser Asn Pro Asn Lys Pro Lys Arg Gln Xaa Asn Gln Leu Gln 
    50                  55                  60                  


Tyr Leu Leu Arg Val Val Leu Lys Xaa Leu Trp Lys His Gln Phe Ala 
65                  70                  75                  80  


Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp 
                85                  90                  95      


Tyr Tyr Lys Ile Ile Lys Xaa Pro Met Asp Met Gly Xaa Ile Lys Lys 
            100                 105                 110         


Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp 
        115                 120                 125             


Phe Asn Xaa Met Phe Xaa Asn Cys Tyr Ile Tyr Asn Lys Pro Gly Asp 
    130                 135                 140                 


Asp Ile Val Leu Met Ala Glu Ala Leu Glu Lys Leu Phe Leu Gln Lys 
145                 150                 155                 160 


Ile Asn Glu Leu Pro Xaa Glu Glu Xaa Glu Ile Met Ile Val Gln Ala 
                165                 170                 175     


Lys Gly Arg Gly Arg Gly Arg Lys Glu Xaa Gly Xaa Ala Lys Pro Gly 
            180                 185                 190         


Val Ser Xaa Val Pro Asn Xaa Xaa Gln Ala Ser Xaa Pro Pro Gln Xaa 
        195                 200                 205             


Gln Xaa Pro Gln Pro Asn Pro Pro Pro Val Gln Ala Xaa Pro His Pro 
    210                 215                 220                 


Phe Pro Ala Val Xaa Pro Asp Leu Ile Val Gln Xaa Pro Val Met Xaa 
225                 230                 235                 240 


Val Val Pro Pro Gln Pro Leu Gln Xaa Pro Pro Pro Val Pro Pro Gln 
                245                 250                 255     


Pro Gln Pro Pro Pro Ala Pro Ala Pro Gln Pro Val Gln Ser His Pro 
            260                 265                 270         


Pro Ile Ile Ala Ala Xaa Pro Gln Pro Val Lys Xaa Lys Lys Gly Val 
        275                 280                 285             


Lys Arg Lys Ala Asp Xaa Xaa Xaa Pro Xaa Xaa Ile Asp Pro Ile His 
    290                 295                 300                 


Glu Pro Pro Ser Leu Pro Pro Glu Pro Lys Xaa Xaa Lys Leu Gly Gln 
305                 310                 315                 320 


Arg Arg Glu Ser Ser Arg Pro Val Lys Pro Pro Lys Lys Asp Val Pro 
                325                 330                 335     


Asp Ser Gln Gln His Pro Ala Pro Glu Lys Ser Ser Lys Val Ser Glu 
            340                 345                 350         


Gln Leu Lys Cys Cys Ser Gly Ile Leu Lys Glu Met Phe Ala Lys Lys 
        355                 360                 365             


His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Val Glu Ala 
    370                 375                 380                 


Leu Gly Leu His Asp Tyr Cys Asp Ile Ile Lys His Pro Met Asp Met 
385                 390                 395                 400 


Ser Xaa Ile Lys Ser Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala Gln 
                405                 410                 415     


Glu Phe Gly Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr 
            420                 425                 430         


Asn Pro Pro Asp His Glu Val Val Ala Met Ala Arg Lys Leu Gln Asp 
        435                 440                 445             


Val Phe Glu Met Arg Phe Ala Lys Met Pro Asp Glu Pro Glu Glu Pro 
    450                 455                 460                 


Val Val Ala Val Ser Ser Pro Ala Val Pro Pro Pro Xaa Lys Val Val 
465                 470                 475                 480 


Ala Pro Pro Ser Ser Ser Asp Ser Ser Ser Asp Ser Ser Ser Asp Ser 
                485                 490                 495     


Asp Ser Ser Xaa Asp Asp Ser Glu Glu Glu Arg Ala Gln Arg Leu Ala 
            500                 505                 510         


Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu 
        515                 520                 525             


Ser Gln Pro Gln Gln Asn Lys Pro Lys Lys Lys Glu Lys Asp Lys Lys 
    530                 535                 540                 


Glu Lys Lys Lys Glu Lys His Lys Arg Lys Glu Glu Val Glu Glu Asn 
545                 550                 555                 560 


Lys Lys Ser Lys Ala Lys Glu Pro Pro Pro Lys Lys Xaa Lys Lys Asn 
                565                 570                 575     


Asn Ser Ser Asn Ser Asn Val Ser Lys Lys Glu Pro Ala Pro Met Lys 
            580                 585                 590         


Ser Lys Pro Pro Pro Xaa Tyr Glu Ser Glu Glu Glu Asp Lys Cys Lys 
        595                 600                 605             


Pro Met Ser Tyr Glu Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys 
    610                 615                 620                 


Leu Pro Gly Glu Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg 
625                 630                 635                 640 


Glu Pro Ser Leu Lys Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe 
                645                 650                 655     


Glu Xaa Leu Lys Pro Ser Xaa Leu Arg Glu Leu Glu Arg Tyr Val Xaa 
            660                 665                 670         


Ser Cys Leu Arg Lys Lys Arg Lys Pro Gln Ala Glu Lys Val Asp Val 
        675                 680                 685             


Ile Ala Gly Ser Ser Lys Met Lys Gly Phe Ser Ser Ser Glu Ser Glu 
    690                 695                 700                 


Ser Ser Ser Glu Ser Ser Ser Ser Asp Ser Glu Asp Ser Glu Xaa Glu 
705                 710                 715                 720 


Met Ala Pro Lys Ser Lys Lys Lys Gly His Pro Gly Arg Glu Gln Lys 
                725                 730                 735     


Lys His His His His His His Gln Gln Met Gln Gln Ala Pro Ala Pro 
            740                 745                 750         


Val Pro Gln Gln Pro Pro Pro Pro Pro Gln Gln Pro Pro Pro Pro Pro 
        755                 760                 765             


Pro Pro Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Ser 
    770                 775                 780                 


Met Pro Gln Gln Ala Ala Pro Ala Met Lys Ser Ser Pro Pro Pro Phe 
785                 790                 795                 800 


Ile Ala Xaa Gln Val Pro Val Leu Glu Pro Gln Leu Pro Gly Ser Val 
                805                 810                 815     


Phe Asp Pro Ile Gly His Phe Xaa Gln Pro Ile Leu His Leu Pro Gln 
            820                 825                 830         


Pro Glu Leu Pro Pro His Leu Pro Gln Pro Pro Glu His Ser Xaa Pro 
        835                 840                 845             


Pro His Leu Asn Gln His Ala Val Val Ser Pro Pro Ala Leu His Asn 
    850                 855                 860                 


Ala Leu Pro Gln Gln Pro Ser Arg Pro Ser Asn Arg Ala Ala Ala Leu 
865                 870                 875                 880 


Pro Pro Lys Pro Ala Arg Pro Pro Ala Val Ser Pro Ala Leu Xaa Gln 
                885                 890                 895     


Xaa Pro Leu Leu Pro Gln Pro Pro Met Ala Gln Pro Pro Gln Val Leu 
            900                 905                 910         


Leu Glu Asp Glu Glu Pro Pro Ala Pro Pro Leu Xaa Ser Met Gln Met 
        915                 920                 925             


Gln Leu Tyr Leu Gln Gln Leu Gln Lys Val Gln Pro Pro Xaa Pro Leu 
    930                 935                 940                 


Leu Pro Ser Val Lys Val Gln Ser Gln Pro Pro Pro Pro Leu Pro Pro 
945                 950                 955                 960 


Pro Pro His Pro Ser Val Gln Gln Gln Leu Gln Gln Gln Pro Pro Pro 
                965                 970                 975     


Pro Pro Pro Pro Gln Pro Gln Pro Pro Pro Gln Gln Gln His Gln Pro 
            980                 985                 990         


Pro Pro Arg Pro Val His Leu Gln  Pro Met Gln Phe Ser  Xaa His Ile 
        995                 1000                 1005             


Gln Gln  Pro Pro Pro Pro Gln  Gly Gln Gln Pro Pro  His Pro Pro 
    1010                 1015                 1020             


Pro Gly  Gln Gln Pro Pro Pro  Pro Gln Pro Ala Lys  Pro Gln Gln 
    1025                 1030                 1035             


Val Ile  Gln His His His Ser  Pro Arg His His Lys  Ser Asp Pro 
    1040                 1045                 1050             


Tyr Ser  Xaa Gly His Leu Arg  Glu Ala Pro Ser Pro  Leu Met Ile 
    1055                 1060                 1065             


His Ser  Pro Gln Met Ser Gln  Phe Gln Ser Leu Xaa  His Gln Ser 
    1070                 1075                 1080             


Pro Pro  Gln Gln Asn Val Gln  Pro Lys Lys Gln Glu  Leu Arg Ala 
    1085                 1090                 1095             


Ala Ser  Val Val Gln Pro Gln  Pro Leu Val Val Val  Lys Glu Glu 
    1100                 1105                 1110             


Lys Ile  His Ser Pro Ile Ile  Arg Ser Glu Pro Phe  Ser Pro Ser 
    1115                 1120                 1125             


Leu Arg  Pro Glu Pro Pro Lys  His Pro Glu Ser Ile  Lys Ala Pro 
    1130                 1135                 1140             


Val His  Leu Pro Gln Arg Pro  Glu Met Lys Pro Val  Asp Val Gly 
    1145                 1150                 1155             


Arg Pro  Val Ile Arg Pro Pro  Glu Gln Asn Ala Pro  Pro Pro Gly 
    1160                 1165                 1170             


Ala Pro  Asp Lys Asp Lys Gln  Lys Gln Glu Pro Lys  Xaa Pro Val 
    1175                 1180                 1185             


Ala Pro  Lys Lys Asp Leu Lys  Ile Lys Asn Met Gly  Ser Trp Ala 
    1190                 1195                 1200             


Ser Leu  Val Gln Lys His Pro  Xaa Xaa Pro Ser Ser  Xaa Ala Lys 
    1205                 1210                 1215             


Ser Ser  Ser Asp Ser Phe Glu  Gln Phe Arg Arg Ala  Ala Arg Glu 
    1220                 1225                 1230             


Lys Glu  Glu Arg Glu Lys Ala  Leu Lys Ala Gln Ala  Glu His Ala 
    1235                 1240                 1245             


Glu Lys  Glu Lys Glu Arg Leu  Arg Gln Glu Arg Met  Arg Ser Arg 
    1250                 1255                 1260             


Glu Asp  Glu Asp Ala Leu Glu  Gln Ala Arg Arg Ala  His Glu Glu 
    1265                 1270                 1275             


Ala Arg  Arg Arg Gln Glu Gln  Gln Gln Gln Gln Arg  Gln Glu Gln 
    1280                 1285                 1290             


Gln Gln  Gln Gln Gln Gln Gln  Ala Ala Ala Val Ala  Ala Ala Ala 
    1295                 1300                 1305             


Xaa Pro  Gln Ala Gln Ser Ser  Gln Pro Gln Ser Met  Leu Asp Gln 
    1310                 1315                 1320             


Gln Arg  Glu Leu Ala Arg Lys  Arg Glu Gln Glu Arg  Arg Arg Arg 
    1325                 1330                 1335             


Glu Ala  Met Ala Ala Xaa Ile  Asp Met Asn Phe Gln  Ser Asp Leu 
    1340                 1345                 1350             


Leu Ser  Ile Phe Glu Glu Asn  Leu Phe 
    1355                 1360         


<210> 4391
<211> 651
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<400> 4391
Met Gly Lys Lys His Lys Lys His Lys Ser Asp Lys His Leu Tyr Glu 
1               5                   10                  15      


Glu Tyr Val Glu Lys Pro Leu Lys Leu Val Leu Lys Val Gly Gly Asn 
            20                  25                  30          


Glu Val Xaa Glu Leu Ser Xaa Gly Ser Ser Gly His Asp Ser Ser Leu 
        35                  40                  45              


Phe Glu Asp Lys Asn Asp His Asp Lys His Lys Asp Arg Lys Arg Lys 
    50                  55                  60                  


Lys Arg Lys Lys Gly Glu Lys Gln Ile Pro Gly Glu Glu Lys Gly Arg 
65                  70                  75                  80  


Lys Arg Arg Arg Val Lys Glu Asp Lys Lys Lys Arg Asp Arg Asp Arg 
                85                  90                  95      


Val Glu Asn Glu Ala Glu Lys Asp Leu Gln Cys His Ala Pro Val Arg 
            100                 105                 110         


Leu Asp Leu Pro Pro Glu Lys Pro Leu Xaa Ser Ser Leu Ala Lys Gln 
        115                 120                 125             


Glu Glu Val Glu Gln Xaa Pro Leu Gln Glu Ala Leu Asn Gln Leu Met 
    130                 135                 140                 


Arg Gln Leu Gln Arg Lys Asp Pro Ser Ala Phe Phe Ser Phe Pro Val 
145                 150                 155                 160 


Xaa Asp Phe Ile Ala Pro Gly Tyr Ser Met Ile Ile Lys His Pro Met 
                165                 170                 175     


Asp Phe Ser Xaa Met Lys Glu Lys Ile Lys Asn Asn Asp Tyr Gln Ser 
            180                 185                 190         


Ile Glu Glu Leu Lys Asp Asn Phe Lys Leu Met Cys Xaa Asn Ala Met 
        195                 200                 205             


Ile Tyr Asn Lys Pro Glu Xaa Ile Tyr Tyr Lys Ala Ala Lys Lys Leu 
    210                 215                 220                 


Leu His Ser Gly Met Lys Ile Leu Ser Gln Glu Arg Ile Gln Ser Leu 
225                 230                 235                 240 


Lys Gln Ser Ile Asp Phe Met Ala Asp Leu Gln Lys Xaa Arg Lys Gln 
                245                 250                 255     


Lys Asp Gly Xaa Asp Xaa Ser Gln Ser Gly Glu Asp Gly Gly Cys Trp 
            260                 265                 270         


Gln Arg Glu Arg Glu Asp Ser Gly Asp Ala Glu Ala His Ala Phe Lys 
        275                 280                 285             


Ser Pro Ser Lys Glu Asn Lys Lys Lys Asp Lys Asp Met Leu Glu Asp 
    290                 295                 300                 


Lys Phe Lys Ser Asn Asn Leu Glu Arg Glu Gln Glu Gln Leu Asp Arg 
305                 310                 315                 320 


Ile Val Lys Glu Ser Gly Gly Lys Leu Xaa Arg Arg Leu Val Asn Ser 
                325                 330                 335     


Gln Cys Glu Phe Glu Arg Arg Lys Pro Asp Gly Xaa Xaa Xaa Leu Gly 
            340                 345                 350         


Leu Leu His Pro Val Asp Pro Ile Val Gly Glu Pro Gly Tyr Cys Pro 
        355                 360                 365             


Val Arg Leu Gly Met Xaa Xaa Gly Arg Leu Gln Ser Gly Val Asn Xaa 
    370                 375                 380                 


Leu Gln Gly Phe Lys Glu Asp Lys Arg Asn Lys Val Xaa Pro Val Leu 
385                 390                 395                 400 


Tyr Leu Asn Tyr Gly Pro Tyr Ser Ser Tyr Ala Pro His Tyr Asp Ser 
                405                 410                 415     


Xaa Phe Ala Asn Ile Ser Lys Asp Asp Ser Asp Leu Ile Tyr Ser Xaa 
            420                 425                 430         


Tyr Gly Glu Asp Ser Asp Leu Pro Ser Asp Phe Ser Ile His Glu Phe 
        435                 440                 445             


Leu Ala Xaa Cys Gln Asp Tyr Pro Tyr Val Met Ala Asp Ser Leu Leu 
    450                 455                 460                 


Asp Val Leu Xaa Lys Gly Gly His Ser Arg Xaa Leu Gln Glu Met Glu 
465                 470                 475                 480 


Met Ser Leu Pro Glu Asp Glu Gly His Xaa Arg Xaa Leu Asp Xaa Ala 
                485                 490                 495     


Lys Glu Met Glu Ile Xaa Glu Val Glu Pro Pro Gly Arg Leu Asp Ser 
            500                 505                 510         


Ser Xaa Gln Asp Arg Leu Ile Ala Leu Lys Ala Val Xaa Asn Phe Gly 
        515                 520                 525             


Val Pro Val Glu Val Phe Asp Ser Glu Glu Ala Glu Ile Phe Gln Lys 
    530                 535                 540                 


Lys Leu Asp Glu Xaa Xaa Arg Leu Leu Arg Glu Leu Gln Glu Ala Gln 
545                 550                 555                 560 


Asn Glu Arg Leu Ser Xaa Arg Pro Pro Pro Asn Met Ile Cys Leu Leu 
                565                 570                 575     


Gly Pro Ser Tyr Arg Glu Met His Leu Ala Glu Gln Val Xaa Asn Asn 
            580                 585                 590         


Leu Lys Glu Leu Ala Gln Gln Val Xaa Pro Gly Asp Ile Val Ser Xaa 
        595                 600                 605             


Tyr Gly Val Arg Lys Ala Met Gly Ile Ser Ile Pro Ser Pro Val Met 
    610                 615                 620                 


Glu Asn Asn Phe Val Asp Leu Xaa Glu Asp Xaa Glu Glu Pro Lys Lys 
625                 630                 635                 640 


Xaa Asp Val Ala Glu Cys Gly Pro Gly Gly Ser 
                645                 650     


<210> 4392
<211> 652
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<400> 4392
Met Gly Lys Lys His Lys Lys His Lys Ser Asp Lys His Leu Tyr Glu 
1               5                   10                  15      


Glu Tyr Val Glu Lys Pro Leu Lys Leu Val Leu Lys Val Gly Gly Asn 
            20                  25                  30          


Glu Val Xaa Glu Leu Ser Xaa Gly Ser Ser Gly His Asp Ser Ser Leu 
        35                  40                  45              


Phe Glu Asp Lys Asn Asp His Asp Lys His Lys Asp Arg Lys Arg Lys 
    50                  55                  60                  


Lys Arg Lys Lys Gly Glu Lys Gln Ile Pro Gly Glu Glu Lys Gly Arg 
65                  70                  75                  80  


Lys Arg Arg Arg Val Lys Glu Asp Lys Lys Lys Arg Asp Arg Asp Arg 
                85                  90                  95      


Val Glu Asn Glu Ala Glu Lys Asp Leu Gln Cys His Ala Pro Val Arg 
            100                 105                 110         


Leu Asp Leu Pro Pro Glu Lys Pro Leu Xaa Ser Ser Leu Ala Lys Gln 
        115                 120                 125             


Glu Glu Val Glu Gln Xaa Pro Leu Gln Glu Ala Leu Asn Gln Leu Met 
    130                 135                 140                 


Arg Gln Leu Gln Arg Lys Asp Pro Ser Ala Phe Phe Ser Phe Pro Val 
145                 150                 155                 160 


Xaa Asp Phe Ile Ala Pro Gly Tyr Ser Met Ile Ile Lys His Pro Met 
                165                 170                 175     


Asp Phe Ser Xaa Met Lys Glu Lys Ile Lys Asn Asn Asp Tyr Gln Ser 
            180                 185                 190         


Ile Glu Glu Leu Lys Asp Asn Phe Lys Leu Met Cys Xaa Asn Ala Met 
        195                 200                 205             


Ile Tyr Asn Lys Pro Glu Xaa Ile Tyr Tyr Lys Ala Ala Lys Lys Leu 
    210                 215                 220                 


Leu His Ser Gly Met Lys Ile Leu Ser Gln Glu Arg Ile Gln Ser Leu 
225                 230                 235                 240 


Lys Gln Ser Ile Asp Phe Met Ala Asp Leu Gln Lys Xaa Arg Lys Gln 
                245                 250                 255     


Lys Asp Gly Xaa Asp Xaa Ser Gln Ser Gly Glu Asp Gly Gly Cys Trp 
            260                 265                 270         


Gln Arg Glu Arg Glu Asp Ser Gly Asp Ala Glu Ala His Ala Phe Lys 
        275                 280                 285             


Ser Pro Ser Lys Glu Asn Lys Lys Lys Asp Lys Asp Met Leu Glu Asp 
    290                 295                 300                 


Lys Phe Lys Ser Asn Asn Leu Glu Arg Glu Gln Glu Gln Leu Asp Arg 
305                 310                 315                 320 


Ile Val Lys Glu Ser Gly Gly Lys Leu Xaa Arg Arg Leu Val Asn Ser 
                325                 330                 335     


Gln Cys Glu Phe Glu Arg Arg Lys Pro Asp Gly Xaa Xaa Xaa Leu Gly 
            340                 345                 350         


Leu Leu His Pro Val Asp Pro Ile Val Gly Glu Pro Gly Tyr Cys Pro 
        355                 360                 365             


Val Arg Leu Gly Met Xaa Xaa Gly Arg Leu Gln Ser Gly Val Asn Xaa 
    370                 375                 380                 


Leu Gln Gly Phe Lys Glu Asp Lys Arg Asn Lys Val Xaa Pro Val Leu 
385                 390                 395                 400 


Tyr Leu Asn Tyr Gly Pro Tyr Ser Ser Tyr Ala Pro His Tyr Asp Ser 
                405                 410                 415     


Xaa Phe Ala Asn Ile Ser Lys Asp Asp Ser Asp Leu Ile Tyr Ser Xaa 
            420                 425                 430         


Tyr Gly Glu Asp Ser Asp Leu Pro Ser Asp Phe Ser Ile His Glu Phe 
        435                 440                 445             


Leu Ala Xaa Cys Gln Asp Tyr Pro Tyr Val Met Ala Asp Ser Leu Leu 
    450                 455                 460                 


Asp Val Leu Xaa Lys Gly Gly His Ser Arg Xaa Leu Gln Glu Met Glu 
465                 470                 475                 480 


Met Ser Leu Pro Glu Asp Glu Gly His Xaa Arg Xaa Leu Asp Xaa Ala 
                485                 490                 495     


Lys Glu Met Glu Gln Ile Xaa Glu Val Glu Pro Pro Gly Arg Leu Asp 
            500                 505                 510         


Ser Ser Xaa Gln Asp Arg Leu Ile Ala Leu Lys Ala Val Xaa Asn Phe 
        515                 520                 525             


Gly Val Pro Val Glu Val Phe Asp Ser Glu Glu Ala Glu Ile Phe Gln 
    530                 535                 540                 


Lys Lys Leu Asp Glu Xaa Xaa Arg Leu Leu Arg Glu Leu Gln Glu Ala 
545                 550                 555                 560 


Gln Asn Glu Arg Leu Ser Xaa Arg Pro Pro Pro Asn Met Ile Cys Leu 
                565                 570                 575     


Leu Gly Pro Ser Tyr Arg Glu Met His Leu Ala Glu Gln Val Xaa Asn 
            580                 585                 590         


Asn Leu Lys Glu Leu Ala Gln Gln Val Xaa Pro Gly Asp Ile Val Ser 
        595                 600                 605             


Xaa Tyr Gly Val Arg Lys Ala Met Gly Ile Ser Ile Pro Ser Pro Val 
    610                 615                 620                 


Met Glu Asn Asn Phe Val Asp Leu Xaa Glu Asp Xaa Glu Glu Pro Lys 
625                 630                 635                 640 


Lys Xaa Asp Val Ala Glu Cys Gly Pro Gly Gly Ser 
                645                 650         


<210> 4393
<211> 32
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<400> 4393
Pro Ser Pro Val Met Glu Asn Asn Phe Val Asp Leu Xaa Glu Asp Xaa 
1               5                   10                  15      


Glu Glu Pro Lys Lys Xaa Asp Val Ala Glu Cys Gly Pro Gly Gly Ser 
            20                  25                  30          


<210> 4394
<211> 109
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<400> 4394
Gln Lys Lys Leu Asp Glu Xaa Xaa Arg Leu Leu Arg Glu Leu Gln Glu 
1               5                   10                  15      


Ala Gln Asn Glu Arg Leu Ser Xaa Arg Pro Pro Pro Asn Met Ile Cys 
            20                  25                  30          


Leu Leu Gly Pro Ser Tyr Arg Glu Met His Leu Ala Glu Gln Val Xaa 
        35                  40                  45              


Asn Asn Leu Lys Glu Leu Ala Gln Gln Val Xaa Pro Gly Asp Ile Val 
    50                  55                  60                  


Ser Xaa Tyr Gly Val Arg Lys Ala Met Gly Ile Ser Ile Pro Ser Pro 
65                  70                  75                  80  


Val Met Glu Asn Asn Phe Val Asp Leu Xaa Glu Asp Xaa Glu Glu Pro 
                85                  90                  95      


Lys Lys Xaa Asp Val Ala Glu Cys Gly Pro Gly Gly Ser 
            100                 105                 


<210> 4395
<211> 336
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<400> 4395
Asp Leu Asp Val Gly Asn Trp Arg Glu Xaa Glu Asp Pro Glu Ala Glu 
1               5                   10                  15      


Glu Leu Glu Glu Ser Ser Pro Glu Arg Glu Pro Ser Glu Leu Leu Val 
            20                  25                  30          


Gly Asp Gly Gly Ser Glu Glu Ser Gln Glu Ala Ala Arg Lys Ala Ser 
        35                  40                  45              


His Gln Asn Leu Leu His Phe Leu Ser Glu Val Ala Tyr Leu Met Glu 
    50                  55                  60                  


Pro Leu Cys Ile Ser Ser Asn Glu Ser Ser Glu Gly Cys Cys Pro Pro 
65                  70                  75                  80  


Ser Gly Xaa Arg Gln Glu Gly Arg Glu Ile Lys Ala Ser Glu Gly Glu 
                85                  90                  95      


Arg Glu Leu Cys Arg Glu Xaa Glu Glu Leu Ser Ala Lys Gly Asp Pro 
            100                 105                 110         


Leu Val Ala Glu Lys Pro Leu Gly Glu Asn Gly Lys Pro Glu Val Ala 
        115                 120                 125             


Ser Ala Pro Ser Val Ile Cys Xaa Val Gln Gly Leu Leu Xaa Glu Ser 
    130                 135                 140                 


Glu Glu Gly Glu Ala Gln Gln Glu Ser Lys Gly Glu Asp Gln Gly Glu 
145                 150                 155                 160 


Val Tyr Val Ser Glu Met Glu Asp Gln Pro Pro Ser Gly Glu Cys Asp 
                165                 170                 175     


Asp Ala Phe Asn Ile Lys Glu Xaa Pro Leu Val Asp Xaa Leu Phe Ser 
            180                 185                 190         


His Ala Xaa Ser Ser Lys Leu Xaa Asp Leu Ser Gln Asp Asp Pro Val 
        195                 200                 205             


Gln Asp His Leu Leu Phe Lys Lys Xaa Leu Leu Pro Val Trp Lys Met 
    210                 215                 220                 


Ile Ala Ser His Arg Phe Ser Ser Pro Phe Leu Lys Pro Val Ser Glu 
225                 230                 235                 240 


Arg Gln Ala Pro Gly Tyr Lys Asp Val Val Lys Arg Pro Met Asp Leu 
                245                 250                 255     


Xaa Ser Leu Lys Arg Asn Leu Ser Lys Gly Arg Ile Arg Xaa Met Ala 
            260                 265                 270         


Gln Phe Leu Arg Asp Leu Met Leu Met Phe Gln Asn Ala Val Met Tyr 
        275                 280                 285             


Asn Asp Ser Asp His His Val Tyr His Met Ala Val Glu Met Arg Gln 
    290                 295                 300                 


Glu Val Leu Glu Gln Ile Gln Val Leu Tyr Ala Asp Xaa Cys Ser Leu 
305                 310                 315                 320 


Trp Asn Leu Asp Phe Arg Xaa Pro Met Arg Ile Lys Val Ile Ser Arg 
                325                 330                 335     


<210> 4396
<211> 861
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<400> 4396
Gly Lys His Lys Leu Leu Ser Xaa Gly Pro Xaa Glu Pro Trp Ser Ile 
1               5                   10                  15      


Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met Arg Ser Gly Asp Gln 
            20                  25                  30          


Asn Trp Val Ser Val Ser Arg Ala Ile Lys Pro Phe Ala Glu Pro Gly 
        35                  40                  45              


Arg Pro Pro Asp Trp Phe Ser Gln Lys His Cys Ala Ser Gln Tyr Ser 
    50                  55                  60                  


Glu Leu Leu Glu Xaa Xaa Glu Xaa Pro Lys Arg Lys Arg Gly Glu Lys 
65                  70                  75                  80  


Gly Glu Val Val Glu Xaa Val Glu Asp Val Ile Val Arg Lys Leu Xaa 
                85                  90                  95      


Ala Glu Arg Val Glu Glu Leu Lys Lys Val Ile Lys Glu Xaa Gln Glu 
            100                 105                 110         


Arg Tyr Arg Arg Leu Lys Arg Asp Ala Glu Leu Ile Gln Ala Gly His 
        115                 120                 125             


Met Asp Ser Arg Leu Asp Glu Leu Cys Asn Asp Ile Ala Xaa Lys Lys 
    130                 135                 140                 


Lys Leu Glu Glu Glu Glu Ala Glu Val Lys Arg Lys Ala Xaa Asp Ala 
145                 150                 155                 160 


Ala Tyr Gln Ala Arg Gln Ala Val Lys Xaa Pro Pro Arg Arg Leu Pro 
                165                 170                 175     


Xaa Val Met Val Arg Ser Pro Ile Asp Ser Ala Ser Pro Gly Gly Asp 
            180                 185                 190         


Tyr Pro Leu Gly Asp Leu Xaa Pro Xaa Xaa Met Glu Glu Ala Xaa Ser 
        195                 200                 205             


Gly Val Xaa Pro Gly Xaa Leu Pro Ser Xaa Pro Val Xaa Ser Phe Pro 
    210                 215                 220                 


Gly Ile Pro Asp Xaa Leu Pro Pro Gly Ser Ala Pro Leu Glu Ala Pro 
225                 230                 235                 240 


Met Xaa Pro Val Xaa Asp Asp Ser Pro Gln Lys Lys Met Leu Gly Gln 
                245                 250                 255     


Lys Ala Xaa Pro Pro Pro Ser Pro Leu Leu Ser Glu Leu Leu Lys Lys 
            260                 265                 270         


Gly Ser Leu Leu Pro Xaa Ser Pro Arg Leu Val Asn Glu Ser Glu Met 
        275                 280                 285             


Ala Val Ala Ser Gly His Leu Asn Ser Xaa Gly Val Leu Leu Glu Val 
    290                 295                 300                 


Gly Gly Val Leu Pro Met Ile His Gly Gly Glu Ile Gln Gln Xaa Pro 
305                 310                 315                 320 


Asn Xaa Val Ala Ala Ser Pro Ala Ala Ser Val Ser Gln Pro Asp Asn 
                325                 330                 335     


Cys Val Pro Met Glu Ala Val Gly Asp Pro His Xaa Val Xaa Val Ser 
            340                 345                 350         


Met Asp Ser Ser Glu Ile Ser Met Ile Ile Asn Ser Ile Lys Glu Glu 
        355                 360                 365             


Cys Phe Arg Ser Gly Val Ala Glu Ala Pro Val Gly Ser Lys Ala Pro 
    370                 375                 380                 


Ser Ile Asp Gly Lys Glu Glu Leu Asp Leu Ala Glu Lys Met Asp Ile 
385                 390                 395                 400 


Ala Val Ser Tyr Xaa Gly Glu Glu Leu Asp Phe Glu Xaa Val Gly Asp 
                405                 410                 415     


Ile Ile Ala Ile Ile Glu Asp Lys Val Asp Asp His Pro Glu Val Leu 
            420                 425                 430         


Asp Val Ala Ala Val Glu Ala Ala Leu Ser Phe Cys Glu Glu Asn Asp 
        435                 440                 445             


Asp Pro Gln Ser Leu Pro Gly Pro Trp Glu His Pro Ile Gln Gln Glu 
    450                 455                 460                 


Arg Asp Lys Pro Val Pro Leu Pro Ala Pro Glu Met Xaa Val Lys Gln 
465                 470                 475                 480 


Glu Arg Leu Asp Phe Glu Glu Xaa Glu Asn Lys Gly Ile His Glu Leu 
                485                 490                 495     


Val Asp Ile Arg Glu Pro Ser Ala Glu Ile Lys Val Glu Pro Ala Glu 
            500                 505                 510         


Pro Glu Pro Val Ile Ser Gly Ala Glu Ile Val Ala Gly Val Val Pro 
        515                 520                 525             


Ala Xaa Ser Met Glu Pro Pro Glu Leu Arg Ser Gln Asp Leu Asp Glu 
    530                 535                 540                 


Glu Leu Gly Ser Xaa Ala Ala Gly Glu Ile Val Glu Ala Asp Val Ala 
545                 550                 555                 560 


Ile Gly Lys Gly Asp Glu Xaa Pro Leu Xaa Asn Val Lys Xaa Glu Ala 
                565                 570                 575     


Ser Pro Glu Ser Met Leu Ser Pro Ser His Gly Ser Asn Pro Ile Glu 
            580                 585                 590         


Asp Pro Leu Glu Ala Glu Xaa Gln His Lys Phe Glu Met Ser Asp Ser 
        595                 600                 605             


Leu Lys Glu Glu Ser Gly Xaa Ile Phe Gly Ser Gln Ile Lys Asp Ala 
    610                 615                 620                 


Pro Gly Glu Asp Glu Glu Glu Asp Gly Val Ser Glu Ala Ala Ser Leu 
625                 630                 635                 640 


Glu Glu Pro Lys Glu Glu Asp Gln Gly Glu Gly Tyr Leu Ser Glu Met 
                645                 650                 655     


Asp Asn Glu Pro Pro Val Ser Glu Ser Asp Asp Gly Phe Ser Ile His 
            660                 665                 670         


Asn Ala Xaa Leu Gln Ser His Xaa Leu Ala Asp Ser Ile Pro Ser Ser 
        675                 680                 685             


Pro Ala Ser Ser Gln Phe Ser Val Cys Ser Glu Asp Gln Glu Ala Ile 
    690                 695                 700                 


Gln Ala Gln Lys Ile Trp Lys Lys Ala Ile Met Leu Val Trp Arg Ala 
705                 710                 715                 720 


Ala Ala Asn His Arg Tyr Ala Asn Val Phe Leu Gln Pro Val Xaa Asp 
                725                 730                 735     


Asp Ile Ala Pro Gly Tyr His Ser Ile Val Gln Arg Pro Met Asp Leu 
            740                 745                 750         


Ser Xaa Ile Lys Lys Asn Ile Glu Asn Gly Leu Ile Arg Ser Xaa Ala 
        755                 760                 765             


Glu Phe Gln Arg Asp Ile Met Leu Met Phe Gln Asn Ala Val Met Tyr 
    770                 775                 780                 


Asn Ser Ser Asp His Asp Val Tyr His Met Ala Val Glu Met Gln Arg 
785                 790                 795                 800 


Asp Val Leu Glu Gln Ile Gln Gln Phe Leu Ala Xaa Gln Leu Ile Met 
                805                 810                 815     


Gln Xaa Ser Glu Ser Gly Ile Ser Ala Lys Ser Leu Arg Gly Arg Asp 
            820                 825                 830         


Ser Xaa Arg Lys Gln Asp Ala Ser Glu Lys Asp Gly Gly Xaa Arg Gly 
        835                 840                 845             


Arg Arg Cys Ala Ile Glu Ala Asp Met Lys Met Lys Lys 
    850                 855                 860     


<210> 4397
<211> 892
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<400> 4397
Gly Lys His Lys Leu Leu Ser Xaa Gly Pro Xaa Glu Pro Trp Ser Ile 
1               5                   10                  15      


Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met Arg Ser Gly Asp Gln 
            20                  25                  30          


Asn Trp Val Ser Val Ser Arg Ala Ile Lys Pro Phe Ala Glu Pro Gly 
        35                  40                  45              


Arg Pro Pro Asp Trp Phe Ser Gln Lys His Cys Ala Ser Gln Tyr Ser 
    50                  55                  60                  


Glu Leu Leu Glu Xaa Xaa Glu Xaa Pro Lys Arg Lys Arg Gly Glu Lys 
65                  70                  75                  80  


Gly Glu Val Val Glu Xaa Val Glu Asp Val Ile Val Arg Lys Leu Xaa 
                85                  90                  95      


Ala Glu Arg Val Glu Glu Leu Lys Lys Val Ile Lys Glu Xaa Gln Glu 
            100                 105                 110         


Arg Tyr Arg Arg Leu Lys Arg Asp Ala Glu Leu Ile Gln Ala Gly His 
        115                 120                 125             


Met Asp Ser Arg Leu Asp Glu Leu Cys Asn Asp Ile Ala Xaa Lys Lys 
    130                 135                 140                 


Lys Leu Glu Glu Glu Glu Ala Glu Val Lys Arg Lys Ala Xaa Asp Ala 
145                 150                 155                 160 


Ala Tyr Gln Ala Arg Gln Ala Val Lys Xaa Pro Pro Arg Arg Leu Pro 
                165                 170                 175     


Xaa Val Met Val Arg Ser Pro Ile Asp Ser Ala Ser Pro Gly Gly Asp 
            180                 185                 190         


Tyr Pro Leu Gly Asp Leu Xaa Pro Xaa Xaa Met Glu Glu Ala Xaa Ser 
        195                 200                 205             


Gly Val Xaa Pro Gly Xaa Leu Pro Ser Xaa Pro Val Xaa Ser Phe Pro 
    210                 215                 220                 


Gly Ile Pro Asp Xaa Leu Pro Pro Gly Ser Ala Pro Leu Glu Ala Pro 
225                 230                 235                 240 


Met Xaa Pro Val Xaa Asp Asp Ser Pro Gln Lys Lys Met Leu Gly Gln 
                245                 250                 255     


Lys Ala Xaa Pro Pro Pro Ser Pro Leu Leu Ser Glu Leu Leu Lys Lys 
            260                 265                 270         


Gly Ser Leu Leu Pro Xaa Ser Pro Arg Leu Val Asn Glu Ser Glu Met 
        275                 280                 285             


Ala Val Ala Ser Gly His Leu Asn Ser Xaa Gly Val Leu Leu Glu Val 
    290                 295                 300                 


Gly Gly Val Leu Pro Met Ile His Gly Gly Glu Ile Gln Gln Xaa Pro 
305                 310                 315                 320 


Asn Xaa Val Ala Ala Ser Pro Ala Ala Ser Glu Ser Val Ser Gln Ala 
                325                 330                 335     


Xaa Ile Val Met Met Pro Ala Leu Pro Ala Pro Ser Ser Ala Pro Ala 
            340                 345                 350         


Val Ser Xaa Xaa Glu Ser Val Ala Pro Val Ser Gln Pro Asp Asn Cys 
        355                 360                 365             


Val Pro Met Glu Ala Val Gly Asp Pro His Xaa Val Xaa Val Ser Met 
    370                 375                 380                 


Asp Ser Ser Glu Ile Ser Met Ile Ile Asn Ser Ile Lys Glu Glu Cys 
385                 390                 395                 400 


Phe Arg Ser Gly Val Ala Glu Ala Pro Val Gly Ser Lys Ala Pro Ser 
                405                 410                 415     


Ile Asp Gly Lys Glu Glu Leu Asp Leu Ala Glu Lys Met Asp Ile Ala 
            420                 425                 430         


Val Ser Tyr Xaa Gly Glu Glu Leu Asp Phe Glu Xaa Val Gly Asp Ile 
        435                 440                 445             


Ile Ala Ile Ile Glu Asp Lys Val Asp Asp His Pro Glu Val Leu Asp 
    450                 455                 460                 


Val Ala Ala Val Glu Ala Ala Leu Ser Phe Cys Glu Glu Asn Asp Asp 
465                 470                 475                 480 


Pro Gln Ser Leu Pro Gly Pro Trp Glu His Pro Ile Gln Gln Glu Arg 
                485                 490                 495     


Asp Lys Pro Val Pro Leu Pro Ala Pro Glu Met Xaa Val Lys Gln Glu 
            500                 505                 510         


Arg Leu Asp Phe Glu Glu Xaa Glu Asn Lys Gly Ile His Glu Leu Val 
        515                 520                 525             


Asp Ile Arg Glu Pro Ser Ala Glu Ile Lys Val Glu Pro Ala Glu Pro 
    530                 535                 540                 


Glu Pro Val Ile Ser Gly Ala Glu Ile Val Ala Gly Val Val Pro Ala 
545                 550                 555                 560 


Xaa Ser Met Glu Pro Pro Glu Leu Arg Ser Gln Asp Leu Asp Glu Glu 
                565                 570                 575     


Leu Gly Ser Xaa Ala Ala Gly Glu Ile Val Glu Ala Asp Val Ala Ile 
            580                 585                 590         


Gly Lys Gly Asp Glu Xaa Pro Leu Xaa Asn Val Lys Xaa Glu Ala Ser 
        595                 600                 605             


Pro Glu Ser Met Leu Ser Pro Ser His Gly Ser Asn Pro Ile Glu Asp 
    610                 615                 620                 


Pro Leu Glu Ala Glu Xaa Gln His Lys Phe Glu Met Ser Asp Ser Leu 
625                 630                 635                 640 


Lys Glu Glu Ser Gly Xaa Ile Phe Gly Ser Gln Ile Lys Asp Ala Pro 
                645                 650                 655     


Gly Glu Asp Glu Glu Glu Asp Gly Val Ser Glu Ala Ala Ser Leu Glu 
            660                 665                 670         


Glu Pro Lys Glu Glu Asp Gln Gly Glu Gly Tyr Leu Ser Glu Met Asp 
        675                 680                 685             


Asn Glu Pro Pro Val Ser Glu Ser Asp Asp Gly Phe Ser Ile His Asn 
    690                 695                 700                 


Ala Xaa Leu Gln Ser His Xaa Leu Ala Asp Ser Ile Pro Ser Ser Pro 
705                 710                 715                 720 


Ala Ser Ser Gln Phe Ser Val Cys Ser Glu Asp Gln Glu Ala Ile Gln 
                725                 730                 735     


Ala Gln Lys Ile Trp Lys Lys Ala Ile Met Leu Val Trp Arg Ala Ala 
            740                 745                 750         


Ala Asn His Arg Tyr Ala Asn Val Phe Leu Gln Pro Val Xaa Asp Asp 
        755                 760                 765             


Ile Ala Pro Gly Tyr His Ser Ile Val Gln Arg Pro Met Asp Leu Ser 
    770                 775                 780                 


Xaa Ile Lys Lys Asn Ile Glu Asn Gly Leu Ile Arg Ser Xaa Ala Glu 
785                 790                 795                 800 


Phe Gln Arg Asp Ile Met Leu Met Phe Gln Asn Ala Val Met Tyr Asn 
                805                 810                 815     


Ser Ser Asp His Asp Val Tyr His Met Ala Val Glu Met Gln Arg Asp 
            820                 825                 830         


Val Leu Glu Gln Ile Gln Gln Phe Leu Ala Xaa Gln Leu Ile Met Gln 
        835                 840                 845             


Xaa Ser Glu Ser Gly Ile Ser Ala Lys Ser Leu Arg Gly Arg Asp Ser 
    850                 855                 860                 


Xaa Arg Lys Gln Asp Ala Ser Glu Lys Asp Gly Gly Xaa Arg Gly Arg 
865                 870                 875                 880 


Arg Cys Ala Ile Glu Ala Asp Met Lys Met Lys Lys 
                885                 890         


<210> 4398
<211> 195
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 4398
Gly Ser Lys Ala Pro Ser Ile Asp Gly Lys Glu Glu Leu Asp Leu Ala 
1               5                   10                  15      


Glu Lys Met Asp Ile Ala Val Ser Tyr Xaa Gly Glu Glu Leu Asp Phe 
            20                  25                  30          


Glu Xaa Val Gly Asp Ile Ile Ala Ile Ile Glu Asp Lys Ala Ser Pro 
        35                  40                  45              


Glu Ser Met Leu Ser Pro Ser His Gly Ser Asn Pro Ile Glu Asp Pro 
    50                  55                  60                  


Leu Glu Ala Glu Xaa Gln His Lys Phe Glu Met Ser Asp Ser Leu Lys 
65                  70                  75                  80  


Glu Glu Ser Gly Xaa Ile Phe Gly Ser Gln Ile Lys Asp Ala Pro Gly 
                85                  90                  95      


Glu Asp Glu Glu Glu Asp Gly Val Ser Glu Ala Ala Ser Leu Glu Glu 
            100                 105                 110         


Pro Lys Glu Glu Asp Gln Gly Glu Gly Tyr Leu Ser Glu Met Asp Asn 
        115                 120                 125             


Glu Pro Pro Val Ser Glu Ser Asp Asp Gly Phe Ser Ile His Asn Ala 
    130                 135                 140                 


Xaa Leu Gln Ser His Xaa Leu Ala Asp Ser Ile Pro Ser Ser Pro Ala 
145                 150                 155                 160 


Ser Ser Gln Phe Ser Val Cys Ser Glu Asp Gln Glu Ala Ile Gln Ala 
                165                 170                 175     


Gln Lys Ile Trp Lys Lys Ala Ile Met Leu Val Trp Arg Ala Ala Ala 
            180                 185                 190         


Asn His Arg 
        195 


<210> 4399
<211> 292
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<400> 4399
His Xaa Val Xaa Val Ser Met Asp Ser Ser Glu Ile Ser Met Ile Ile 
1               5                   10                  15      


Asn Ser Ile Lys Glu Glu Cys Phe Arg Ser Gly Val Ala Glu Ala Pro 
            20                  25                  30          


Val Gly Ser Lys Ala Pro Ser Ile Asp Gly Lys Glu Glu Leu Asp Leu 
        35                  40                  45              


Ala Glu Lys Met Asp Ile Ala Val Ser Tyr Xaa Gly Glu Glu Leu Asp 
    50                  55                  60                  


Phe Glu Xaa Val Gly Asp Ile Ile Ala Ile Ile Glu Asp Lys Val Asp 
65                  70                  75                  80  


Asp His Pro Glu Val Leu Asp Val Ala Ala Val Glu Ala Ala Leu Ser 
                85                  90                  95      


Phe Cys Glu Glu Asn Asp Asp Pro Gln Ser Leu Pro Gly Pro Trp Glu 
            100                 105                 110         


His Pro Ile Gln Gln Glu Arg Asp Lys Pro Val Pro Leu Pro Ala Pro 
        115                 120                 125             


Glu Met Xaa Val Lys Gln Glu Arg Leu Asp Phe Glu Glu Xaa Glu Asn 
    130                 135                 140                 


Lys Gly Ile His Glu Leu Val Asp Ile Arg Glu Pro Ser Ala Glu Ile 
145                 150                 155                 160 


Lys Val Glu Pro Ala Glu Pro Glu Pro Val Ile Ser Gly Ala Glu Ile 
                165                 170                 175     


Val Ala Gly Val Val Pro Ala Xaa Ser Met Glu Pro Pro Glu Leu Arg 
            180                 185                 190         


Ser Gln Asp Leu Asp Glu Glu Leu Gly Ser Xaa Ala Ala Gly Glu Ile 
        195                 200                 205             


Val Glu Ala Asp Val Ala Ile Gly Lys Gly Asp Glu Xaa Pro Leu Xaa 
    210                 215                 220                 


Asn Val Lys Xaa Glu Ala Ser Pro Glu Ser Met Leu Ser Pro Ser His 
225                 230                 235                 240 


Gly Ser Asn Pro Ile Glu Asp Pro Leu Glu Ala Glu Xaa Gln His Lys 
                245                 250                 255     


Phe Glu Met Ser Asp Ser Leu Lys Glu Glu Ser Gly Xaa Ile Phe Gly 
            260                 265                 270         


Ser Gln Ile Lys Gly Gln Ser Tyr Ser Arg Ala Arg Gly Lys Lys Glu 
        275                 280                 285             


Arg Leu Leu Ala 
    290         


<210> 4400
<211> 187
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<400> 4400
Lys Glu Xaa Gln Glu Arg Tyr Arg Arg Leu Lys Arg Asp Ala Glu Leu 
1               5                   10                  15      


Ile Gln Ala Gly His Met Asp Ser Arg Leu Asp Glu Leu Cys Asn Asp 
            20                  25                  30          


Ile Ala Xaa Lys Lys Lys Leu Glu Glu Glu Glu Ala Glu Val Lys Arg 
        35                  40                  45              


Lys Ala Xaa Asp Ala Ala Tyr Gln Ala Arg Gln Ala Val Lys Xaa Pro 
    50                  55                  60                  


Pro Arg Arg Leu Pro Xaa Val Met Val Arg Ser Pro Ile Asp Ser Ala 
65                  70                  75                  80  


Ser Pro Gly Gly Asp Tyr Pro Leu Gly Asp Leu Xaa Pro Xaa Xaa Met 
                85                  90                  95      


Glu Glu Ala Xaa Ser Gly Val Asn Glu Ser Glu Met Ala Val Ala Ser 
            100                 105                 110         


Gly His Leu Asn Ser Xaa Gly Val Leu Leu Glu Val Gly Gly Val Leu 
        115                 120                 125             


Pro Met Ile His Gly Gly Glu Ile Gln Gln Xaa Pro Asn Xaa Val Ala 
    130                 135                 140                 


Ala Ser Pro Ala Ala Ser Val Ser Gln Pro Asp Asn Cys Val Pro Met 
145                 150                 155                 160 


Glu Ala Val Gly Asp Pro His Xaa Val Xaa Val Ser Met Asp Ser Ser 
                165                 170                 175     


Glu Ile Ser Met Ile Ile Asn Ser Ile Lys Glu 
            180                 185         


<210> 4401
<211> 48
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<400> 4401
Met Ala Xaa Gly Xaa Gly Lys His Lys Leu Leu Ser Xaa Gly Pro Xaa 
1               5                   10                  15      


Glu Pro Trp Ser Ile Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met 
            20                  25                  30          


Arg Ser Gly Asp Gln Asn Cys Ile Val Leu Pro Ser Xaa Arg Ser Phe 
        35                  40                  45              


<210> 4402
<211> 39
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<400> 4402
Met Ala Xaa Gly Xaa Gly Lys His Lys Leu Leu Ser Xaa Gly Pro Xaa 
1               5                   10                  15      


Glu Pro Trp Ser Ile Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met 
            20                  25                  30          


Arg Ser Gly Asp Gln Asn Trp 
        35                  


<210> 4403
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<400> 4403
Met Ala Xaa Gly Xaa Gly Lys His Lys Leu Leu Ser Xaa Gly Pro Xaa 
1               5                   10                  15      


Glu Pro Trp Ser Ile Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met 
            20                  25                  30          


Arg Ser Gly Asp Gln Asn Trp Gly Trp Ser Tyr Ser Val Xaa Gln Ala 
        35                  40                  45              


Gly Val Gln Trp Arg Asp Leu Gly Ser Leu Gln Pro Leu Asp Phe Leu 
    50                  55                  60                  


Gly Ser Arg Asp Pro Pro Xaa Ser Ala Ala Gln Val Ala Gly Xaa Xaa 
65                  70                  75                  80  


Gly Arg Arg Val Ser Val Ser Arg Ala Ile Lys Pro Phe Ala Glu Pro 
                85                  90                  95      


Gly Arg Pro Pro Asp Trp Phe Ser Gln Lys His Cys Ala Ser Gln Tyr 
            100                 105                 110         


Ser Glu Leu Leu Glu Xaa Xaa Glu Xaa Pro 
        115                 120         


<210> 4404
<211> 67
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<400> 4404
Met Ala Xaa Gly Xaa Gly Lys His Lys Leu Leu Ser Xaa Gly Pro Xaa 
1               5                   10                  15      


Glu Pro Trp Ser Ile Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met 
            20                  25                  30          


Arg Ser Gly Asp Gln Asn Trp Leu Glu Cys Ser Gly Ala Ile Trp Ala 
        35                  40                  45              


His Cys Ser Leu Leu Xaa Ser Trp Ala Gln Gly Ile Leu Leu Pro Gln 
    50                  55                  60                  


Leu Pro Lys 
65          


<210> 4405
<211> 79
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<400> 4405
Met Ala Xaa Gly Xaa Gly Lys His Lys Leu Leu Ser Xaa Gly Pro Xaa 
1               5                   10                  15      


Glu Pro Trp Ser Ile Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met 
            20                  25                  30          


Arg Ser Gly Asp Gln Asn Trp Val Ser Val Ser Arg Ala Ile Lys Pro 
        35                  40                  45              


Phe Ala Glu Pro Gly Arg Pro Pro Asp Trp Phe Ser Gln Lys His Cys 
    50                  55                  60                  


Ala Ser Gln Tyr Ser Glu Leu Leu Glu Xaa Xaa Glu Xaa Pro Lys 
65                  70                  75                  


<210> 4406
<211> 878
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<400> 4406
Met Ala Xaa Gly Xaa Gly Lys His Lys Leu Leu Ser Xaa Gly Pro Xaa 
1               5                   10                  15      


Glu Pro Trp Ser Ile Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met 
            20                  25                  30          


Arg Ser Gly Asp Gln Asn Trp Val Ser Val Ser Arg Ala Ile Lys Pro 
        35                  40                  45              


Phe Ala Glu Pro Gly Arg Pro Pro Asp Trp Phe Ser Gln Lys His Cys 
    50                  55                  60                  


Ala Ser Gln Tyr Ser Glu Leu Leu Glu Xaa Xaa Glu Xaa Pro Lys Arg 
65                  70                  75                  80  


Lys Arg Gly Glu Lys Gly Glu Val Val Glu Xaa Val Glu Asp Val Ile 
                85                  90                  95      


Val Arg Lys Leu Xaa Ala Glu Arg Val Glu Glu Leu Lys Lys Val Ile 
            100                 105                 110         


Lys Glu Xaa Gln Glu Arg Tyr Arg Arg Leu Lys Arg Asp Ala Glu Leu 
        115                 120                 125             


Ile Gln Ala Gly His Met Asp Ser Arg Leu Asp Glu Leu Cys Asn Asp 
    130                 135                 140                 


Ile Ala Xaa Lys Lys Lys Leu Glu Glu Glu Glu Ala Glu Val Lys Arg 
145                 150                 155                 160 


Lys Ala Xaa Asp Ala Ala Tyr Gln Ala Arg Gln Ala Val Lys Xaa Pro 
                165                 170                 175     


Pro Arg Arg Leu Pro Xaa Val Met Val Arg Ser Pro Ile Asp Ser Ala 
            180                 185                 190         


Ser Pro Gly Gly Asp Tyr Pro Leu Gly Asp Leu Xaa Pro Xaa Xaa Met 
        195                 200                 205             


Glu Glu Ala Xaa Ser Gly Val Asn Glu Ser Glu Met Ala Val Ala Ser 
    210                 215                 220                 


Gly His Leu Asn Ser Xaa Gly Val Leu Leu Glu Val Gly Gly Val Leu 
225                 230                 235                 240 


Pro Met Ile His Gly Gly Glu Ile Gln Gln Xaa Pro Asn Xaa Val Ala 
                245                 250                 255     


Ala Ser Pro Ala Ala Ser Gly Ala Pro Xaa Leu Ser Arg Leu Leu Glu 
            260                 265                 270         


Ala Gly Pro Xaa Gln Phe Xaa Xaa Pro Leu Ala Ser Phe Xaa Xaa Val 
        275                 280                 285             


Ala Ser Glu Pro Pro Val Lys Leu Val Pro Pro Pro Val Glu Ser Val 
    290                 295                 300                 


Ser Gln Ala Xaa Ile Val Met Met Pro Ala Leu Pro Ala Pro Ser Ser 
305                 310                 315                 320 


Ala Pro Ala Val Ser Xaa Xaa Glu Ser Val Ala Pro Val Ser Gln Pro 
                325                 330                 335     


Asp Asn Cys Val Pro Met Glu Ala Val Gly Asp Pro His Xaa Val Xaa 
            340                 345                 350         


Val Ser Met Asp Ser Ser Glu Ile Ser Met Ile Ile Asn Ser Ile Lys 
        355                 360                 365             


Glu Glu Cys Phe Arg Ser Gly Val Ala Glu Ala Pro Val Gly Ser Lys 
    370                 375                 380                 


Ala Pro Ser Ile Asp Gly Lys Glu Glu Leu Asp Leu Ala Glu Lys Met 
385                 390                 395                 400 


Asp Ile Ala Val Ser Tyr Xaa Gly Glu Glu Leu Asp Phe Glu Xaa Val 
                405                 410                 415     


Gly Asp Ile Ile Ala Ile Ile Glu Asp Lys Val Asp Asp His Pro Glu 
            420                 425                 430         


Val Leu Asp Val Ala Ala Val Glu Ala Ala Leu Ser Phe Cys Glu Glu 
        435                 440                 445             


Asn Asp Asp Pro Gln Ser Leu Pro Gly Pro Trp Glu His Pro Ile Gln 
    450                 455                 460                 


Gln Glu Arg Asp Lys Pro Val Pro Leu Pro Ala Pro Glu Met Xaa Val 
465                 470                 475                 480 


Lys Gln Glu Arg Leu Asp Phe Glu Glu Xaa Glu Asn Lys Gly Ile His 
                485                 490                 495     


Glu Leu Val Asp Ile Arg Glu Pro Ser Ala Glu Ile Lys Val Glu Pro 
            500                 505                 510         


Ala Glu Pro Glu Pro Val Ile Ser Gly Ala Glu Ile Val Ala Gly Val 
        515                 520                 525             


Val Pro Ala Xaa Ser Met Glu Pro Pro Glu Leu Arg Ser Gln Asp Leu 
    530                 535                 540                 


Asp Glu Glu Leu Gly Ser Xaa Ala Ala Gly Glu Ile Val Glu Ala Asp 
545                 550                 555                 560 


Val Ala Ile Gly Lys Gly Asp Glu Xaa Pro Leu Xaa Asn Val Lys Xaa 
                565                 570                 575     


Glu Ala Ser Pro Glu Ser Met Leu Ser Pro Ser His Gly Ser Asn Pro 
            580                 585                 590         


Ile Glu Asp Pro Leu Glu Ala Glu Xaa Gln His Lys Phe Glu Met Ser 
        595                 600                 605             


Asp Ser Leu Lys Glu Glu Ser Gly Xaa Ile Phe Gly Ser Gln Ile Lys 
    610                 615                 620                 


Asp Ala Pro Gly Glu Asp Glu Glu Glu Asp Gly Val Ser Glu Ala Ala 
625                 630                 635                 640 


Ser Leu Glu Glu Pro Lys Glu Glu Asp Gln Gly Glu Gly Tyr Leu Ser 
                645                 650                 655     


Glu Met Asp Asn Glu Pro Pro Val Ser Glu Ser Asp Asp Gly Phe Ser 
            660                 665                 670         


Ile His Asn Ala Xaa Leu Gln Ser His Xaa Leu Ala Asp Ser Ile Pro 
        675                 680                 685             


Ser Ser Pro Ala Ser Ser Gln Phe Ser Val Cys Ser Glu Asp Gln Glu 
    690                 695                 700                 


Ala Ile Gln Ala Gln Lys Ile Trp Lys Lys Ala Ile Met Leu Val Trp 
705                 710                 715                 720 


Arg Ala Ala Ala Asn His Arg Tyr Ala Asn Val Phe Leu Gln Pro Val 
                725                 730                 735     


Xaa Asp Asp Ile Ala Pro Gly Tyr His Ser Ile Val Gln Arg Pro Met 
            740                 745                 750         


Asp Leu Ser Xaa Ile Lys Lys Asn Ile Glu Asn Gly Leu Ile Arg Ser 
        755                 760                 765             


Xaa Ala Glu Phe Gln Arg Asp Ile Met Leu Met Phe Gln Asn Ala Val 
    770                 775                 780                 


Met Tyr Asn Ser Ser Asp His Asp Val Tyr His Met Ala Val Glu Met 
785                 790                 795                 800 


Gln Arg Asp Val Leu Glu Gln Ile Gln Gln Phe Leu Ala Xaa Gln Leu 
                805                 810                 815     


Ile Met Gln Xaa Ser Glu Ser Gly Ile Ser Ala Lys Ser Leu Arg Gly 
            820                 825                 830         


Arg Asp Ser Xaa Arg Lys Gln Asp Ala Ser Glu Lys Asp Ser Val Pro 
        835                 840                 845             


Met Gly Ser Pro Ala Phe Leu Leu Ser Leu Phe Asp Gly Gly Xaa Arg 
    850                 855                 860                 


Gly Arg Arg Cys Ala Ile Glu Ala Asp Met Lys Met Lys Lys 
865                 870                 875             


<210> 4407
<211> 1235
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1083)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<400> 4407
Met Ala Xaa Gly Xaa Gly Lys His Lys Leu Leu Ser Xaa Gly Pro Xaa 
1               5                   10                  15      


Glu Pro Trp Ser Ile Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met 
            20                  25                  30          


Arg Ser Gly Asp Gln Asn Trp Val Ser Val Ser Arg Ala Ile Lys Pro 
        35                  40                  45              


Phe Ala Glu Pro Gly Arg Pro Pro Asp Trp Phe Ser Gln Lys His Cys 
    50                  55                  60                  


Ala Ser Gln Tyr Ser Glu Leu Leu Glu Xaa Xaa Glu Xaa Pro Lys Arg 
65                  70                  75                  80  


Lys Arg Gly Glu Lys Gly Glu Val Val Glu Xaa Val Glu Asp Val Ile 
                85                  90                  95      


Val Arg Lys Leu Xaa Ala Glu Arg Val Glu Glu Leu Lys Lys Val Ile 
            100                 105                 110         


Lys Glu Xaa Gln Glu Arg Tyr Arg Arg Leu Lys Arg Asp Ala Glu Leu 
        115                 120                 125             


Ile Gln Ala Gly His Met Asp Ser Arg Leu Asp Glu Leu Cys Asn Asp 
    130                 135                 140                 


Ile Ala Xaa Lys Lys Lys Leu Glu Glu Glu Glu Ala Glu Val Lys Arg 
145                 150                 155                 160 


Lys Ala Xaa Asp Ala Ala Tyr Gln Ala Arg Gln Ala Val Lys Xaa Pro 
                165                 170                 175     


Pro Arg Arg Leu Pro Xaa Val Met Val Arg Ser Pro Ile Asp Ser Ala 
            180                 185                 190         


Ser Pro Gly Gly Asp Tyr Pro Leu Gly Asp Leu Xaa Pro Xaa Xaa Met 
        195                 200                 205             


Glu Glu Ala Xaa Ser Gly Val Asn Glu Ser Glu Met Ala Val Ala Ser 
    210                 215                 220                 


Gly His Leu Asn Ser Xaa Gly Val Leu Leu Glu Val Gly Gly Val Leu 
225                 230                 235                 240 


Pro Met Ile His Gly Gly Glu Ile Gln Gln Xaa Pro Asn Xaa Val Ala 
                245                 250                 255     


Ala Ser Pro Ala Ala Ser Gly Ala Pro Xaa Leu Ser Arg Leu Leu Glu 
            260                 265                 270         


Ala Gly Pro Xaa Gln Phe Xaa Xaa Pro Leu Ala Ser Phe Xaa Xaa Val 
        275                 280                 285             


Ala Ser Glu Pro Pro Val Lys Leu Val Pro Pro Pro Val Glu Ser Val 
    290                 295                 300                 


Ser Gln Ala Xaa Ile Val Met Met Pro Ala Leu Pro Ala Pro Ser Ser 
305                 310                 315                 320 


Ala Pro Ala Val Ser Xaa Xaa Glu Ser Val Ala Pro Val Ser Gln Pro 
                325                 330                 335     


Asp Asn Cys Val Pro Met Glu Ala Val Gly Asp Pro His Xaa Val Xaa 
            340                 345                 350         


Val Ser Met Asp Ser Ser Glu Ile Ser Met Ile Ile Asn Ser Ile Lys 
        355                 360                 365             


Glu Glu Cys Phe Arg Ser Gly Val Ala Glu Ala Pro Val Gly Ser Lys 
    370                 375                 380                 


Ala Pro Ser Ile Asp Gly Lys Glu Glu Leu Asp Leu Ala Glu Lys Met 
385                 390                 395                 400 


Asp Ile Ala Val Ser Tyr Xaa Gly Glu Glu Leu Asp Phe Glu Xaa Val 
                405                 410                 415     


Gly Asp Ile Ile Ala Ile Ile Glu Asp Lys Val Asp Asp His Pro Glu 
            420                 425                 430         


Val Leu Asp Val Ala Ala Val Glu Ala Ala Leu Ser Phe Cys Glu Glu 
        435                 440                 445             


Asn Asp Asp Pro Gln Ser Leu Pro Gly Pro Trp Glu His Pro Ile Gln 
    450                 455                 460                 


Gln Glu Arg Asp Lys Pro Val Pro Leu Pro Ala Pro Glu Met Xaa Val 
465                 470                 475                 480 


Lys Gln Glu Arg Leu Asp Phe Glu Glu Xaa Glu Asn Lys Gly Ile His 
                485                 490                 495     


Glu Leu Val Asp Ile Arg Glu Pro Ser Ala Glu Ile Lys Val Glu Pro 
            500                 505                 510         


Ala Glu Pro Glu Pro Val Ile Ser Gly Ala Glu Ile Val Ala Gly Val 
        515                 520                 525             


Val Pro Ala Xaa Ser Met Glu Pro Pro Glu Leu Arg Ser Gln Asp Leu 
    530                 535                 540                 


Asp Glu Glu Leu Gly Ser Xaa Ala Ala Gly Glu Ile Val Glu Ala Asp 
545                 550                 555                 560 


Val Ala Ile Gly Lys Gly Asp Glu Xaa Pro Leu Xaa Asn Val Lys Xaa 
                565                 570                 575     


Glu Ala Ser Pro Glu Ser Met Leu Ser Pro Ser His Gly Ser Asn Pro 
            580                 585                 590         


Ile Glu Asp Pro Leu Glu Ala Glu Xaa Gln His Lys Phe Glu Met Ser 
        595                 600                 605             


Asp Ser Leu Lys Glu Glu Ser Gly Xaa Ile Phe Gly Ser Gln Ile Lys 
    610                 615                 620                 


Asp Ala Pro Gly Glu Asp Glu Glu Glu Asp Gly Val Ser Glu Ala Ala 
625                 630                 635                 640 


Ser Leu Glu Glu Pro Lys Glu Glu Asp Gln Gly Glu Gly Tyr Leu Ser 
                645                 650                 655     


Glu Met Asp Asn Glu Pro Pro Val Ser Glu Ser Asp Asp Gly Phe Ser 
            660                 665                 670         


Ile His Asn Ala Xaa Leu Gln Ser His Xaa Leu Ala Asp Ser Ile Pro 
        675                 680                 685             


Ser Ser Pro Ala Ser Ser Gln Phe Ser Val Cys Ser Glu Asp Gln Glu 
    690                 695                 700                 


Ala Ile Gln Ala Gln Lys Ile Trp Lys Lys Ala Ile Met Leu Val Trp 
705                 710                 715                 720 


Arg Ala Ala Ala Asn His Arg Tyr Ala Asn Val Phe Leu Gln Pro Val 
                725                 730                 735     


Xaa Asp Asp Ile Ala Pro Gly Tyr His Ser Ile Val Gln Arg Pro Met 
            740                 745                 750         


Asp Leu Ser Xaa Ile Lys Lys Asn Ile Glu Asn Gly Leu Ile Arg Ser 
        755                 760                 765             


Xaa Ala Glu Phe Gln Arg Asp Ile Met Leu Met Phe Gln Asn Ala Val 
    770                 775                 780                 


Met Tyr Asn Ser Ser Asp His Asp Val Tyr His Met Ala Val Glu Met 
785                 790                 795                 800 


Gln Arg Asp Val Leu Glu Gln Ile Gln Gln Phe Leu Ala Xaa Gln Leu 
                805                 810                 815     


Ile Met Gln Xaa Ser Glu Ser Gly Ile Ser Ala Lys Ser Leu Arg Gly 
            820                 825                 830         


Arg Asp Ser Xaa Arg Lys Gln Asp Ala Ser Glu Lys Asp Ser Val Pro 
        835                 840                 845             


Met Gly Ser Pro Ala Phe Leu Leu Ser Leu Phe Met Gly His Glu Trp 
    850                 855                 860                 


Val Trp Leu Asp Ser Glu Gln Asp His Pro Asn Asp Ser Glu Leu Ser 
865                 870                 875                 880 


Asn Asp Cys Arg Ser Leu Phe Ser Ser Trp Asp Ser Ser Leu Asp Leu 
                885                 890                 895     


Asp Val Gly Asn Trp Arg Glu Xaa Glu Asp Pro Glu Ala Glu Glu Leu 
            900                 905                 910         


Glu Glu Ser Ser Pro Glu Arg Glu Pro Ser Glu Leu Leu Val Gly Asp 
        915                 920                 925             


Gly Gly Ser Glu Glu Ser Gln Glu Ala Ala Arg Lys Ala Ser His Gln 
    930                 935                 940                 


Asn Leu Leu His Phe Leu Ser Glu Val Ala Tyr Leu Met Glu Pro Leu 
945                 950                 955                 960 


Cys Ile Ser Ser Asn Glu Ser Ser Glu Gly Cys Cys Pro Pro Ser Gly 
                965                 970                 975     


Xaa Arg Gln Glu Gly Arg Glu Ile Lys Ala Ser Glu Gly Glu Arg Glu 
            980                 985                 990         


Leu Cys Arg Glu Xaa Glu Glu Leu  Ser Ala Lys Gly Asp  Pro Leu Val 
        995                 1000                 1005             


Ala Glu  Lys Pro Leu Gly Glu  Asn Gly Lys Pro Glu  Val Ala Ser 
    1010                 1015                 1020             


Ala Pro  Ser Val Ile Cys Xaa  Val Gln Gly Leu Leu  Xaa Glu Ser 
    1025                 1030                 1035             


Glu Glu  Gly Glu Ala Gln Gln  Glu Ser Lys Gly Glu  Asp Gln Gly 
    1040                 1045                 1050             


Glu Val  Tyr Val Ser Glu Met  Glu Asp Gln Pro Pro  Ser Gly Glu 
    1055                 1060                 1065             


Cys Asp  Asp Ala Phe Asn Ile  Lys Glu Xaa Pro Leu  Val Asp Xaa 
    1070                 1075                 1080             


Leu Phe  Ser His Ala Xaa Ser  Ser Lys Leu Xaa Asp  Leu Ser Gln 
    1085                 1090                 1095             


Asp Asp  Pro Val Gln Asp His  Leu Leu Phe Lys Lys  Xaa Leu Leu 
    1100                 1105                 1110             


Pro Val  Trp Lys Met Ile Ala  Ser His Arg Phe Ser  Ser Pro Phe 
    1115                 1120                 1125             


Leu Lys  Pro Val Ser Glu Arg  Gln Ala Pro Gly Tyr  Lys Asp Val 
    1130                 1135                 1140             


Val Lys  Arg Pro Met Asp Leu  Xaa Ser Leu Lys Arg  Asn Leu Ser 
    1145                 1150                 1155             


Lys Gly  Arg Ile Arg Xaa Met  Ala Gln Phe Leu Arg  Asp Leu Met 
    1160                 1165                 1170             


Leu Met  Phe Gln Asn Ala Val  Met Tyr Asn Asp Ser  Asp His His 
    1175                 1180                 1185             


Val Tyr  His Met Ala Val Glu  Met Arg Gln Glu Val  Leu Glu Gln 
    1190                 1195                 1200             


Ile Gln  Val Leu Asn Ile Trp  Leu Asp Lys Arg Lys  Gly Ser Ser 
    1205                 1210                 1215             


Ser Leu  Glu Gly Glu Pro Ala  Asn Pro Val Asp Asp  Gly Lys Pro 
    1220                 1225                 1230             


Val Phe  
    1235 


<210> 4408
<211> 866
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<400> 4408
Met Ala Xaa Gly Xaa Gly Lys His Lys Leu Leu Ser Xaa Gly Pro Xaa 
1               5                   10                  15      


Glu Pro Trp Ser Ile Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met 
            20                  25                  30          


Arg Ser Gly Asp Gln Asn Trp Val Ser Val Ser Arg Ala Ile Lys Pro 
        35                  40                  45              


Phe Ala Glu Pro Gly Arg Pro Pro Asp Trp Phe Ser Gln Lys His Cys 
    50                  55                  60                  


Ala Ser Gln Tyr Ser Glu Leu Leu Glu Xaa Xaa Glu Xaa Pro Lys Arg 
65                  70                  75                  80  


Lys Arg Gly Glu Lys Gly Glu Val Val Glu Xaa Val Glu Asp Val Ile 
                85                  90                  95      


Val Arg Lys Leu Xaa Ala Glu Arg Val Glu Glu Leu Lys Lys Val Ile 
            100                 105                 110         


Lys Glu Xaa Gln Glu Arg Tyr Arg Arg Leu Lys Arg Asp Ala Glu Leu 
        115                 120                 125             


Ile Gln Ala Gly His Met Asp Ser Arg Leu Asp Glu Leu Cys Asn Asp 
    130                 135                 140                 


Ile Ala Xaa Lys Lys Lys Leu Glu Glu Glu Glu Ala Glu Val Lys Arg 
145                 150                 155                 160 


Lys Ala Xaa Asp Ala Ala Tyr Gln Ala Arg Gln Ala Val Lys Xaa Pro 
                165                 170                 175     


Pro Arg Arg Leu Pro Xaa Val Met Val Arg Ser Pro Ile Asp Ser Ala 
            180                 185                 190         


Ser Pro Gly Gly Asp Tyr Pro Leu Gly Asp Leu Xaa Pro Xaa Xaa Met 
        195                 200                 205             


Glu Glu Ala Xaa Ser Gly Val Xaa Pro Gly Xaa Leu Pro Ser Xaa Pro 
    210                 215                 220                 


Val Xaa Ser Phe Pro Gly Ile Pro Asp Xaa Leu Pro Pro Gly Ser Ala 
225                 230                 235                 240 


Pro Leu Glu Ala Pro Met Xaa Pro Val Xaa Asp Asp Ser Pro Gln Lys 
                245                 250                 255     


Lys Met Leu Gly Gln Lys Ala Xaa Pro Pro Pro Ser Pro Leu Leu Ser 
            260                 265                 270         


Glu Leu Leu Lys Lys Gly Ser Leu Leu Pro Xaa Ser Pro Arg Leu Val 
        275                 280                 285             


Asn Glu Ser Glu Met Ala Val Ala Ser Gly His Leu Asn Ser Xaa Gly 
    290                 295                 300                 


Val Leu Leu Glu Val Gly Gly Val Leu Pro Met Ile His Gly Gly Glu 
305                 310                 315                 320 


Ile Gln Gln Xaa Pro Asn Xaa Val Ala Ala Ser Pro Ala Ala Ser Val 
                325                 330                 335     


Ser Gln Pro Asp Asn Cys Val Pro Met Glu Ala Val Gly Asp Pro His 
            340                 345                 350         


Xaa Val Xaa Val Ser Met Asp Ser Ser Glu Ile Ser Met Ile Ile Asn 
        355                 360                 365             


Ser Ile Lys Glu Glu Cys Phe Arg Ser Gly Val Ala Glu Ala Pro Val 
    370                 375                 380                 


Gly Ser Lys Ala Pro Ser Ile Asp Gly Lys Glu Glu Leu Asp Leu Ala 
385                 390                 395                 400 


Glu Lys Met Asp Ile Ala Val Ser Tyr Xaa Gly Glu Glu Leu Asp Phe 
                405                 410                 415     


Glu Xaa Val Gly Asp Ile Ile Ala Ile Ile Glu Asp Lys Val Asp Asp 
            420                 425                 430         


His Pro Glu Val Leu Asp Val Ala Ala Val Glu Ala Ala Leu Ser Phe 
        435                 440                 445             


Cys Glu Glu Asn Asp Asp Pro Gln Ser Leu Pro Gly Pro Trp Glu His 
    450                 455                 460                 


Pro Ile Gln Gln Glu Arg Asp Lys Pro Val Pro Leu Pro Ala Pro Glu 
465                 470                 475                 480 


Met Xaa Val Lys Gln Glu Arg Leu Asp Phe Glu Glu Xaa Glu Asn Lys 
                485                 490                 495     


Gly Ile His Glu Leu Val Asp Ile Arg Glu Pro Ser Ala Glu Ile Lys 
            500                 505                 510         


Val Glu Pro Ala Glu Pro Glu Pro Val Ile Ser Gly Ala Glu Ile Val 
        515                 520                 525             


Ala Gly Val Val Pro Ala Xaa Ser Met Glu Pro Pro Glu Leu Arg Ser 
    530                 535                 540                 


Gln Asp Leu Asp Glu Glu Leu Gly Ser Xaa Ala Ala Gly Glu Ile Val 
545                 550                 555                 560 


Glu Ala Asp Val Ala Ile Gly Lys Gly Asp Glu Xaa Pro Leu Xaa Asn 
                565                 570                 575     


Val Lys Xaa Glu Ala Ser Pro Glu Ser Met Leu Ser Pro Ser His Gly 
            580                 585                 590         


Ser Asn Pro Ile Glu Asp Pro Leu Glu Ala Glu Xaa Gln His Lys Phe 
        595                 600                 605             


Glu Met Ser Asp Ser Leu Lys Glu Glu Ser Gly Xaa Ile Phe Gly Ser 
    610                 615                 620                 


Gln Ile Lys Asp Ala Pro Gly Glu Asp Glu Glu Glu Asp Gly Val Ser 
625                 630                 635                 640 


Glu Ala Ala Ser Leu Glu Glu Pro Lys Glu Glu Asp Gln Gly Glu Gly 
                645                 650                 655     


Tyr Leu Ser Glu Met Asp Asn Glu Pro Pro Val Ser Glu Ser Asp Asp 
            660                 665                 670         


Gly Phe Ser Ile His Asn Ala Xaa Leu Gln Ser His Xaa Leu Ala Asp 
        675                 680                 685             


Ser Ile Pro Ser Ser Pro Ala Ser Ser Gln Phe Ser Val Cys Ser Glu 
    690                 695                 700                 


Asp Gln Glu Ala Ile Gln Ala Gln Lys Ile Trp Lys Lys Ala Ile Met 
705                 710                 715                 720 


Leu Val Trp Arg Ala Ala Ala Asn His Arg Tyr Ala Asn Val Phe Leu 
                725                 730                 735     


Gln Pro Val Xaa Asp Asp Ile Ala Pro Gly Tyr His Ser Ile Val Gln 
            740                 745                 750         


Arg Pro Met Asp Leu Ser Xaa Ile Lys Lys Asn Ile Glu Asn Gly Leu 
        755                 760                 765             


Ile Arg Ser Xaa Ala Glu Phe Gln Arg Asp Ile Met Leu Met Phe Gln 
    770                 775                 780                 


Asn Ala Val Met Tyr Asn Ser Ser Asp His Asp Val Tyr His Met Ala 
785                 790                 795                 800 


Val Glu Met Gln Arg Asp Val Leu Glu Gln Ile Gln Gln Phe Leu Ala 
                805                 810                 815     


Xaa Gln Leu Ile Met Gln Xaa Ser Glu Ser Gly Ile Ser Ala Lys Ser 
            820                 825                 830         


Leu Arg Gly Arg Asp Ser Xaa Arg Lys Gln Asp Ala Ser Glu Lys Asp 
        835                 840                 845             


Gly Gly Xaa Arg Gly Arg Arg Cys Ala Ile Glu Ala Asp Met Lys Met 
    850                 855                 860                 


Lys Lys 
865     


<210> 4409
<211> 951
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<400> 4409
Met Ala Xaa Gly Xaa Gly Lys His Lys Leu Leu Ser Xaa Gly Pro Xaa 
1               5                   10                  15      


Glu Pro Trp Ser Ile Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met 
            20                  25                  30          


Arg Ser Gly Asp Gln Asn Trp Val Ser Val Ser Arg Ala Ile Lys Pro 
        35                  40                  45              


Phe Ala Glu Pro Gly Arg Pro Pro Asp Trp Phe Ser Gln Lys His Cys 
    50                  55                  60                  


Ala Ser Gln Tyr Ser Glu Leu Leu Glu Xaa Xaa Glu Xaa Pro Lys Arg 
65                  70                  75                  80  


Lys Arg Gly Glu Lys Gly Glu Val Val Glu Xaa Val Glu Asp Val Ile 
                85                  90                  95      


Val Arg Lys Leu Xaa Ala Glu Arg Val Glu Glu Leu Lys Lys Val Ile 
            100                 105                 110         


Lys Glu Xaa Gln Glu Arg Tyr Arg Arg Leu Lys Arg Asp Ala Glu Leu 
        115                 120                 125             


Ile Gln Ala Gly His Met Asp Ser Arg Leu Asp Glu Leu Cys Asn Asp 
    130                 135                 140                 


Ile Ala Xaa Lys Lys Lys Leu Glu Glu Glu Glu Ala Glu Val Lys Arg 
145                 150                 155                 160 


Lys Ala Xaa Asp Ala Ala Tyr Gln Ala Arg Gln Ala Val Lys Xaa Pro 
                165                 170                 175     


Pro Arg Arg Leu Pro Xaa Val Met Val Arg Ser Pro Ile Asp Ser Ala 
            180                 185                 190         


Ser Pro Gly Gly Asp Tyr Pro Leu Gly Asp Leu Xaa Pro Xaa Xaa Met 
        195                 200                 205             


Glu Glu Ala Xaa Ser Gly Val Xaa Pro Gly Xaa Leu Pro Ser Xaa Pro 
    210                 215                 220                 


Val Xaa Ser Phe Pro Gly Ile Pro Asp Xaa Leu Pro Pro Gly Ser Ala 
225                 230                 235                 240 


Pro Leu Glu Ala Pro Met Xaa Pro Val Xaa Asp Asp Ser Pro Gln Lys 
                245                 250                 255     


Lys Met Leu Gly Gln Lys Ala Xaa Pro Pro Pro Ser Pro Leu Leu Ser 
            260                 265                 270         


Glu Leu Leu Lys Lys Gly Ser Leu Leu Pro Xaa Ser Pro Arg Leu Val 
        275                 280                 285             


Asn Glu Ser Glu Met Ala Val Ala Ser Gly His Leu Asn Ser Xaa Gly 
    290                 295                 300                 


Val Leu Leu Glu Val Gly Gly Val Leu Pro Met Ile His Gly Gly Glu 
305                 310                 315                 320 


Ile Gln Gln Xaa Pro Asn Xaa Val Ala Ala Ser Pro Ala Ala Ser Gly 
                325                 330                 335     


Ala Pro Xaa Leu Ser Arg Leu Leu Glu Ala Gly Pro Xaa Gln Phe Xaa 
            340                 345                 350         


Xaa Pro Leu Ala Ser Phe Xaa Xaa Val Ala Ser Glu Pro Pro Val Lys 
        355                 360                 365             


Leu Val Pro Pro Pro Val Glu Ser Val Ser Gln Ala Xaa Ile Val Met 
    370                 375                 380                 


Met Pro Ala Leu Pro Ala Pro Ser Ser Ala Pro Ala Val Ser Xaa Xaa 
385                 390                 395                 400 


Glu Ser Val Ala Pro Val Ser Gln Pro Asp Asn Cys Val Pro Met Glu 
                405                 410                 415     


Ala Val Gly Asp Pro His Xaa Val Xaa Val Ser Met Asp Ser Ser Glu 
            420                 425                 430         


Ile Ser Met Ile Ile Asn Ser Ile Lys Glu Glu Cys Phe Arg Ser Gly 
        435                 440                 445             


Val Ala Glu Ala Pro Val Gly Ser Lys Ala Pro Ser Ile Asp Gly Lys 
    450                 455                 460                 


Glu Glu Leu Asp Leu Ala Glu Lys Met Asp Ile Ala Val Ser Tyr Xaa 
465                 470                 475                 480 


Gly Glu Glu Leu Asp Phe Glu Xaa Val Gly Asp Ile Ile Ala Ile Ile 
                485                 490                 495     


Glu Asp Lys Val Asp Asp His Pro Glu Val Leu Asp Val Ala Ala Val 
            500                 505                 510         


Glu Ala Ala Leu Ser Phe Cys Glu Glu Asn Asp Asp Pro Gln Ser Leu 
        515                 520                 525             


Pro Gly Pro Trp Glu His Pro Ile Gln Gln Glu Arg Asp Lys Pro Val 
    530                 535                 540                 


Pro Leu Pro Ala Pro Glu Met Xaa Val Lys Gln Glu Arg Leu Asp Phe 
545                 550                 555                 560 


Glu Glu Xaa Glu Asn Lys Gly Ile His Glu Leu Val Asp Ile Arg Glu 
                565                 570                 575     


Pro Ser Ala Glu Ile Lys Val Glu Pro Ala Glu Pro Glu Pro Val Ile 
            580                 585                 590         


Ser Gly Ala Glu Ile Val Ala Gly Val Val Pro Ala Xaa Ser Met Glu 
        595                 600                 605             


Pro Pro Glu Leu Arg Ser Gln Asp Leu Asp Glu Glu Leu Gly Ser Xaa 
    610                 615                 620                 


Ala Ala Gly Glu Ile Val Glu Ala Asp Val Ala Ile Gly Lys Gly Asp 
625                 630                 635                 640 


Glu Xaa Pro Leu Xaa Asn Val Lys Xaa Glu Ala Ser Pro Glu Ser Met 
                645                 650                 655     


Leu Ser Pro Ser His Gly Ser Asn Pro Ile Glu Asp Pro Leu Glu Ala 
            660                 665                 670         


Glu Xaa Gln His Lys Phe Glu Met Ser Asp Ser Leu Lys Glu Glu Ser 
        675                 680                 685             


Gly Xaa Ile Phe Gly Ser Gln Ile Lys Asp Ala Pro Gly Glu Asp Glu 
    690                 695                 700                 


Glu Glu Asp Gly Val Ser Glu Ala Ala Ser Leu Glu Glu Pro Lys Glu 
705                 710                 715                 720 


Glu Asp Gln Gly Glu Gly Tyr Leu Ser Glu Met Asp Asn Glu Pro Pro 
                725                 730                 735     


Val Ser Glu Ser Asp Asp Gly Phe Ser Ile His Asn Ala Xaa Leu Gln 
            740                 745                 750         


Ser His Xaa Leu Ala Asp Ser Ile Pro Ser Ser Pro Ala Ser Ser Gln 
        755                 760                 765             


Phe Ser Val Cys Ser Glu Asp Gln Glu Ala Ile Gln Ala Gln Lys Ile 
    770                 775                 780                 


Trp Lys Lys Ala Ile Met Leu Val Trp Arg Ala Ala Ala Asn His Arg 
785                 790                 795                 800 


Tyr Ala Asn Val Phe Leu Gln Pro Val Xaa Asp Asp Ile Ala Pro Gly 
                805                 810                 815     


Tyr His Ser Ile Val Gln Arg Pro Met Asp Leu Ser Xaa Ile Lys Lys 
            820                 825                 830         


Asn Ile Glu Asn Gly Leu Ile Arg Ser Xaa Ala Glu Phe Gln Arg Asp 
        835                 840                 845             


Ile Met Leu Met Phe Gln Asn Ala Val Met Tyr Asn Ser Ser Asp His 
    850                 855                 860                 


Asp Val Tyr His Met Ala Val Glu Met Gln Arg Asp Val Leu Glu Gln 
865                 870                 875                 880 


Ile Gln Gln Phe Leu Ala Xaa Gln Leu Ile Met Gln Xaa Ser Glu Ser 
                885                 890                 895     


Gly Ile Ser Ala Lys Ser Leu Arg Gly Arg Asp Ser Xaa Arg Lys Gln 
            900                 905                 910         


Asp Ala Ser Glu Lys Asp Ser Val Pro Met Gly Ser Pro Ala Phe Leu 
        915                 920                 925             


Leu Ser Leu Phe Asp Gly Gly Xaa Arg Gly Arg Arg Cys Ala Ile Glu 
    930                 935                 940                 


Ala Asp Met Lys Met Lys Lys 
945                 950     


<210> 4410
<211> 857
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<400> 4410
Xaa His Lys Leu Leu Ser Xaa Gly Pro Xaa Glu Pro Trp Ser Ile Arg 
1               5                   10                  15      


Glu Lys Leu Cys Leu Ala Ser Ser Val Met Arg Ser Gly Asp Gln Asn 
            20                  25                  30          


Trp Val Ser Val Ser Arg Ala Ile Lys Pro Phe Ala Glu Pro Gly Arg 
        35                  40                  45              


Pro Pro Asp Trp Phe Ser Gln Lys His Cys Ala Ser Gln Tyr Ser Glu 
    50                  55                  60                  


Leu Leu Glu Xaa Xaa Glu Xaa Pro Lys Arg Lys Arg Gly Glu Lys Gly 
65                  70                  75                  80  


Glu Val Val Glu Xaa Val Glu Asp Val Ile Val Arg Lys Leu Xaa Ala 
                85                  90                  95      


Glu Arg Val Glu Glu Leu Lys Lys Val Ile Lys Glu Xaa Gln Glu Arg 
            100                 105                 110         


Tyr Arg Arg Leu Lys Arg Asp Ala Glu Leu Ile Gln Ala Gly His Met 
        115                 120                 125             


Asp Ser Arg Leu Asp Glu Leu Cys Asn Asp Ile Ala Xaa Lys Lys Lys 
    130                 135                 140                 


Leu Glu Glu Glu Glu Ala Glu Val Lys Arg Lys Ala Xaa Asp Ala Ala 
145                 150                 155                 160 


Tyr Gln Ala Val Lys Xaa Pro Pro Arg Arg Leu Pro Xaa Val Met Val 
                165                 170                 175     


Arg Ser Pro Ile Asp Ser Ala Ser Pro Gly Gly Asp Tyr Pro Leu Gly 
            180                 185                 190         


Asp Leu Xaa Pro Xaa Xaa Met Glu Glu Ala Xaa Ser Gly Val Xaa Pro 
        195                 200                 205             


Gly Xaa Leu Pro Ser Xaa Pro Val Xaa Ser Phe Pro Gly Ile Pro Asp 
    210                 215                 220                 


Xaa Leu Pro Pro Gly Ser Ala Pro Leu Glu Ala Pro Met Xaa Pro Val 
225                 230                 235                 240 


Xaa Asp Asp Ser Pro Gln Lys Lys Met Leu Gly Gln Lys Ala Xaa Pro 
                245                 250                 255     


Pro Pro Ser Pro Leu Leu Ser Glu Leu Leu Lys Lys Gly Ser Leu Leu 
            260                 265                 270         


Pro Xaa Ser Pro Arg Leu Val Asn Glu Ser Glu Met Ala Val Ala Ser 
        275                 280                 285             


Gly His Leu Asn Ser Xaa Gly Val Leu Leu Glu Val Gly Gly Val Leu 
    290                 295                 300                 


Pro Met Ile His Gly Gly Glu Ile Gln Gln Xaa Pro Asn Xaa Val Ala 
305                 310                 315                 320 


Ala Ser Pro Ala Ala Ser Val Ser Gln Pro Asp Asn Cys Val Pro Met 
                325                 330                 335     


Glu Ala Val Gly Asp Pro His Xaa Val Xaa Val Ser Met Asp Ser Ser 
            340                 345                 350         


Glu Ile Ser Met Ile Ile Asn Ser Ile Lys Glu Glu Cys Phe Arg Ser 
        355                 360                 365             


Gly Val Ala Glu Ala Pro Val Gly Ser Lys Ala Pro Ser Ile Asp Gly 
    370                 375                 380                 


Lys Glu Glu Leu Asp Leu Ala Glu Lys Met Asp Ile Ala Val Ser Tyr 
385                 390                 395                 400 


Xaa Gly Glu Glu Leu Asp Phe Glu Xaa Val Gly Asp Ile Ile Ala Ile 
                405                 410                 415     


Ile Glu Asp Lys Val Asp Asp His Pro Glu Val Leu Asp Val Ala Ala 
            420                 425                 430         


Val Glu Ala Ala Leu Ser Phe Cys Glu Glu Asn Asp Asp Pro Gln Ser 
        435                 440                 445             


Leu Pro Gly Pro Trp Glu His Pro Ile Gln Gln Glu Arg Asp Lys Pro 
    450                 455                 460                 


Val Pro Leu Pro Ala Pro Glu Met Xaa Val Lys Gln Glu Arg Leu Asp 
465                 470                 475                 480 


Phe Glu Glu Xaa Glu Asn Lys Gly Ile His Glu Leu Val Asp Ile Arg 
                485                 490                 495     


Glu Pro Ser Ala Glu Ile Lys Val Glu Pro Ala Glu Pro Glu Pro Val 
            500                 505                 510         


Ile Ser Gly Ala Glu Ile Val Ala Gly Val Val Pro Ala Xaa Ser Met 
        515                 520                 525             


Glu Pro Pro Glu Leu Arg Ser Gln Asp Leu Asp Glu Glu Leu Gly Ser 
    530                 535                 540                 


Xaa Ala Ala Gly Glu Ile Val Glu Ala Asp Val Ala Ile Gly Lys Gly 
545                 550                 555                 560 


Asp Glu Xaa Pro Leu Xaa Asn Val Lys Xaa Glu Ala Ser Pro Glu Ser 
                565                 570                 575     


Met Leu Ser Pro Ser His Gly Ser Asn Pro Ile Glu Asp Pro Leu Glu 
            580                 585                 590         


Ala Glu Xaa Gln His Lys Phe Glu Met Ser Asp Ser Leu Lys Glu Glu 
        595                 600                 605             


Ser Gly Xaa Ile Phe Gly Ser Gln Ile Lys Asp Ala Pro Gly Glu Asp 
    610                 615                 620                 


Glu Glu Glu Asp Gly Val Ser Glu Ala Ala Ser Leu Glu Glu Pro Lys 
625                 630                 635                 640 


Glu Glu Asp Gln Gly Glu Gly Tyr Leu Ser Glu Met Asp Asn Glu Pro 
                645                 650                 655     


Pro Val Ser Glu Ser Asp Asp Gly Phe Ser Ile His Asn Ala Xaa Leu 
            660                 665                 670         


Gln Ser His Xaa Leu Ala Asp Ser Ile Pro Ser Ser Pro Ala Ser Ser 
        675                 680                 685             


Gln Phe Ser Val Cys Ser Glu Asp Gln Glu Ala Ile Gln Ala Gln Lys 
    690                 695                 700                 


Ile Trp Lys Lys Ala Ile Met Leu Val Trp Arg Ala Ala Ala Asn His 
705                 710                 715                 720 


Arg Tyr Ala Asn Val Phe Leu Gln Pro Val Xaa Asp Asp Ile Ala Pro 
                725                 730                 735     


Gly Tyr His Ser Ile Val Gln Arg Pro Met Asp Leu Ser Xaa Ile Lys 
            740                 745                 750         


Lys Asn Ile Glu Asn Gly Leu Ile Arg Ser Xaa Ala Glu Phe Gln Arg 
        755                 760                 765             


Asp Ile Met Leu Met Phe Gln Asn Ala Val Met Tyr Asn Ser Ser Asp 
    770                 775                 780                 


His Asp Val Tyr His Met Ala Val Glu Met Gln Arg Asp Val Leu Glu 
785                 790                 795                 800 


Gln Ile Gln Gln Phe Leu Ala Xaa Gln Leu Ile Met Gln Xaa Ser Glu 
                805                 810                 815     


Ser Gly Ile Ser Ala Lys Ser Leu Arg Gly Arg Asp Ser Xaa Arg Lys 
            820                 825                 830         


Gln Asp Ala Ser Glu Lys Asp Gly Gly Xaa Arg Gly Arg Arg Cys Ala 
        835                 840                 845             


Ile Glu Ala Asp Met Lys Met Lys Lys 
    850                 855         


<210> 4411
<211> 36
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<400> 4411
Xaa Ile Ser Ala Lys Ser Leu Arg Gly Arg Asp Ser Xaa Arg Lys Gln 
1               5                   10                  15      


Asp Ala Ser Glu Lys Asp Ser Val Pro Met Gly Ser Pro Ala Phe Leu 
            20                  25                  30          


Leu Ser Leu Phe 
        35      


<210> 4412
<211> 63
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 4412
Met Asp Leu Asn Xaa Ile Lys Lys Arg Leu Glu Asn Lys Tyr Tyr Ala 
1               5                   10                  15      


Lys Ala Ser Glu Cys Ile Glu Asp Phe Asn Xaa Met Phe Ser Asn Cys 
            20                  25                  30          


Tyr Leu Tyr Asn Lys Pro Gly Asp Asp Ile Val Leu Met Ala Gln Ala 
        35                  40                  45              


Leu Glu Lys Leu Phe Met Gln Lys Leu Ser Gln Met Pro Gln Glu 
    50                  55                  60              


<210> 4413
<211> 874
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<400> 4413
Met Asp Leu Asn Xaa Ile Lys Lys Arg Leu Glu Asn Lys Tyr Tyr Ala 
1               5                   10                  15      


Lys Ala Ser Glu Cys Ile Glu Asp Phe Asn Xaa Met Phe Ser Asn Cys 
            20                  25                  30          


Tyr Leu Tyr Asn Lys Pro Gly Asp Asp Ile Val Leu Met Ala Gln Ala 
        35                  40                  45              


Leu Glu Lys Leu Phe Met Gln Lys Leu Ser Gln Met Pro Gln Glu Glu 
    50                  55                  60                  


Gln Val Val Gly Val Lys Glu Arg Ile Lys Lys Gly Xaa Gln Gln Asn 
65                  70                  75                  80  


Ile Ala Val Ser Ser Ala Lys Glu Lys Ser Ser Pro Ser Ala Xaa Glu 
                85                  90                  95      


Lys Val Phe Lys Gln Gln Glu Ile Pro Ser Val Phe Pro Lys Xaa Ser 
            100                 105                 110         


Ile Ser Pro Leu Asn Val Val Gln Gly Ala Ser Val Asn Ser Ser Ser 
        115                 120                 125             


Gln Xaa Ala Ala Gln Val Xaa Lys Gly Val Lys Arg Lys Ala Asp Xaa 
    130                 135                 140                 


Xaa Xaa Pro Ala Xaa Ser Ala Val Lys Ala Ser Ser Glu Phe Ser Pro 
145                 150                 155                 160 


Xaa Phe Xaa Glu Lys Ser Val Ala Leu Pro Pro Ile Lys Glu Asn Met 
                165                 170                 175     


Pro Lys Asn Val Leu Pro Asp Ser Gln Gln Gln Tyr Asn Val Val Lys 
            180                 185                 190         


Xaa Val Lys Val Xaa Glu Gln Leu Arg His Cys Ser Glu Ile Leu Lys 
        195                 200                 205             


Glu Met Leu Ala Lys Lys His Phe Ser Tyr Ala Trp Pro Phe Tyr Asn 
    210                 215                 220                 


Pro Val Asp Val Asn Ala Leu Gly Leu His Asn Tyr Tyr Asp Val Val 
225                 230                 235                 240 


Lys Asn Pro Met Asp Leu Gly Xaa Ile Lys Glu Lys Met Asp Asn Gln 
                245                 250                 255     


Glu Tyr Lys Asp Ala Tyr Lys Phe Ala Ala Asp Val Arg Leu Met Phe 
            260                 265                 270         


Met Asn Cys Tyr Lys Tyr Asn Pro Pro Asp His Glu Val Val Xaa Met 
        275                 280                 285             


Ala Arg Met Leu Gln Asp Val Phe Glu Xaa His Phe Ser Lys Ile Pro 
    290                 295                 300                 


Ile Glu Pro Val Glu Ser Met Pro Leu Cys Tyr Ile Lys Xaa Asp Ile 
305                 310                 315                 320 


Xaa Glu Xaa Xaa Gly Arg Glu Asn Xaa Asn Glu Ala Ser Ser Glu Gly 
                325                 330                 335     


Asn Ser Ser Asp Asp Ser Glu Asp Glu Arg Val Lys Arg Leu Ala Lys 
            340                 345                 350         


Leu Gln Glu Gln Leu Lys Ala Val His Gln Gln Leu Gln Val Leu Ser 
        355                 360                 365             


Gln Val Pro Phe Arg Lys Leu Asn Lys Lys Lys Glu Lys Ser Lys Lys 
    370                 375                 380                 


Glu Lys Lys Lys Glu Lys Val Asn Asn Ser Asn Glu Asn Pro Arg Lys 
385                 390                 395                 400 


Met Cys Glu Gln Met Arg Leu Lys Glu Lys Ser Lys Arg Asn Gln Pro 
                405                 410                 415     


Lys Lys Arg Lys Gln Gln Phe Ile Gly Leu Lys Ser Glu Asp Glu Asp 
            420                 425                 430         


Asn Ala Lys Pro Met Asn Tyr Asp Glu Lys Arg Gln Leu Ser Leu Asn 
        435                 440                 445             


Ile Asn Lys Leu Pro Gly Asp Lys Leu Gly Arg Val Val His Ile Ile 
    450                 455                 460                 


Gln Ser Arg Glu Pro Ser Leu Ser Asn Ser Asn Pro Asp Glu Ile Glu 
465                 470                 475                 480 


Ile Asp Phe Glu Xaa Leu Lys Ala Ser Xaa Leu Arg Glu Leu Glu Lys 
                485                 490                 495     


Tyr Val Ser Ala Cys Leu Arg Lys Arg Pro Leu Lys Pro Pro Ala Lys 
            500                 505                 510         


Lys Ile Met Met Ser Lys Glu Glu Leu His Ser Gln Lys Lys Gln Glu 
        515                 520                 525             


Leu Glu Lys Arg Leu Leu Asp Val Asn Asn Gln Leu Asn Ser Arg Lys 
    530                 535                 540                 


Arg Gln Xaa Lys Ser Asp Lys Xaa Gln Pro Ser Lys Ala Val Glu Asn 
545                 550                 555                 560 


Val Ser Arg Leu Ser Glu Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu 
                565                 570                 575     


Ser Glu Ser Ser Ser Ser Asp Leu Ser Ser Ser Asp Ser Ser Asp Ser 
            580                 585                 590         


Glu Ser Glu Met Phe Pro Lys Phe Xaa Glu Val Lys Pro Asn Asp Ser 
        595                 600                 605             


Pro Ser Lys Glu Asn Val Lys Lys Met Lys Asn Glu Cys Ile Pro Pro 
    610                 615                 620                 


Glu Gly Arg Xaa Gly Val Xaa Gln Ile Gly Tyr Cys Val Gln Asp Xaa 
625                 630                 635                 640 


Xaa Ser Ala Asn Xaa Xaa Leu Val His Gln Xaa Xaa Pro Ser His Val 
                645                 650                 655     


Met Pro Pro Asn His His Gln Leu Ala Phe Asn Tyr Gln Glu Leu Glu 
            660                 665                 670         


His Leu Gln Xaa Val Lys Asn Ile Ser Pro Leu Gln Ile Leu Pro Pro 
        675                 680                 685             


Ser Gly Asp Ser Glu Gln Leu Ser Asn Gly Ile Xaa Val Met His Pro 
    690                 695                 700                 


Ser Gly Asp Ser Asp Xaa Xaa Met Leu Glu Ser Glu Cys Gln Ala Pro 
705                 710                 715                 720 


Val Gln Lys Asp Ile Lys Ile Lys Asn Ala Asp Ser Trp Lys Ser Leu 
                725                 730                 735     


Gly Lys Pro Val Lys Pro Ser Gly Val Met Lys Ser Ser Asp Glu Leu 
            740                 745                 750         


Phe Asn Gln Phe Arg Lys Ala Ala Ile Glu Lys Glu Val Lys Ala Arg 
        755                 760                 765             


Xaa Gln Glu Leu Ile Arg Lys His Leu Glu Gln Asn Xaa Lys Glu Leu 
    770                 775                 780                 


Lys Ala Ser Gln Glu Asn Gln Arg Asp Leu Gly Asn Gly Leu Xaa Val 
785                 790                 795                 800 


Glu Ser Phe Ser Asn Lys Ile Gln Asn Lys Cys Ser Gly Glu Glu Gln 
                805                 810                 815     


Lys Glu His Gln Gln Ser Ser Glu Ala Gln Asp Lys Ser Lys Leu Trp 
            820                 825                 830         


Leu Leu Lys Asp Arg Asp Leu Ala Arg Gln Lys Glu Gln Glu Arg Arg 
        835                 840                 845             


Arg Arg Glu Ala Met Val Gly Xaa Ile Asp Met Xaa Leu Gln Ser Asp 
    850                 855                 860                 


Ile Met Xaa Met Phe Glu Asn Asn Phe Asp 
865                 870                 


<210> 4414
<211> 14
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<400> 4414
Met Ser Leu Pro Ser Arg Gln Xaa Ala Ile Ile Val Asn Pro 
1               5                   10                  


<210> 4415
<211> 32
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<400> 4415
Met Ser Leu Pro Ser Arg Gln Xaa Ala Ile Ile Val Asn Pro Pro Pro 
1               5                   10                  15      


Pro Glu Tyr Ile Asn Xaa Lys Lys Asn Gly Arg Leu Xaa Asn Gln Leu 
            20                  25                  30          


<210> 4416
<211> 52
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<400> 4416
Met Ser Leu Pro Ser Arg Gln Xaa Ala Ile Ile Val Asn Pro Pro Pro 
1               5                   10                  15      


Pro Glu Tyr Ile Asn Xaa Lys Lys Asn Gly Arg Leu Xaa Asn Gln Leu 
            20                  25                  30          


Gln Tyr Leu Gln Lys Val Val Leu Lys Asp Leu Trp Lys His Ser Phe 
        35                  40                  45              


Ser Trp Pro Phe 
    50          


<210> 4417
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 4417
Met Ser Leu Pro Ser Arg Gln Xaa Ala Ile Ile Val Asn Pro Pro Pro 
1               5                   10                  15      


Pro Glu Tyr Ile Asn Xaa Lys Lys Asn Gly Arg Leu Xaa Asn Gln Leu 
            20                  25                  30          


Gln Tyr Leu Gln Lys Val Val Leu Lys Asp Leu Trp Lys His Ser Phe 
        35                  40                  45              


Ser Trp Pro Phe Gln Arg Pro Val Asp Ala Val Lys Leu Gln Leu Pro 
    50                  55                  60                  


Asp Tyr Tyr Xaa Ile Ile Lys Asn Pro Met Asp Leu Asn Xaa Ile Lys 
65                  70                  75                  80  


Lys Arg Leu Glu Asn Lys Tyr Tyr Ala Lys Ala Ser Glu Cys Ile Glu 
                85                  90                  95      


<210> 4418
<211> 100
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<400> 4418
Met Ser Leu Pro Ser Arg Gln Xaa Ala Ile Ile Val Asn Pro Pro Pro 
1               5                   10                  15      


Pro Glu Tyr Ile Asn Xaa Lys Lys Asn Gly Arg Leu Xaa Asn Gln Leu 
            20                  25                  30          


Gln Tyr Leu Gln Lys Val Val Leu Lys Asp Leu Trp Lys His Ser Phe 
        35                  40                  45              


Ser Trp Pro Phe Gln Arg Pro Val Asp Ala Val Lys Leu Gln Leu Pro 
    50                  55                  60                  


Asp Tyr Tyr Xaa Ile Ile Lys Asn Pro Met Asp Leu Asn Xaa Ile Lys 
65                  70                  75                  80  


Lys Arg Leu Glu Asn Lys Tyr Tyr Ala Lys Ala Ser Glu Cys Ile Glu 
                85                  90                  95      


Asp Phe Asn Xaa 
            100 


<210> 4419
<211> 951
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<400> 4419
Met Ser Leu Pro Ser Arg Gln Xaa Ala Ile Ile Val Asn Pro Pro Pro 
1               5                   10                  15      


Pro Glu Tyr Ile Asn Xaa Lys Lys Asn Gly Arg Leu Xaa Asn Gln Leu 
            20                  25                  30          


Gln Tyr Leu Gln Lys Val Val Leu Lys Asp Leu Trp Lys His Ser Phe 
        35                  40                  45              


Ser Trp Pro Phe Gln Arg Pro Val Asp Ala Val Lys Leu Gln Leu Pro 
    50                  55                  60                  


Asp Tyr Tyr Xaa Ile Ile Lys Asn Pro Met Asp Leu Asn Xaa Ile Lys 
65                  70                  75                  80  


Lys Arg Leu Glu Asn Lys Tyr Tyr Ala Lys Ala Ser Glu Cys Ile Glu 
                85                  90                  95      


Asp Phe Asn Xaa Met Phe Ser Asn Cys Tyr Leu Tyr Asn Lys Pro Gly 
            100                 105                 110         


Asp Asp Ile Val Leu Met Ala Gln Ala Leu Glu Lys Leu Phe Met Gln 
        115                 120                 125             


Lys Leu Ser Gln Met Pro Gln Glu Glu Gln Val Val Gly Val Lys Glu 
    130                 135                 140                 


Arg Ile Lys Lys Gly Lys Ala Gly Gly Xaa Gln Gln Asn Ile Ala Val 
145                 150                 155                 160 


Ser Ser Ala Lys Glu Lys Ser Ser Pro Ser Ala Xaa Glu Lys Val Phe 
                165                 170                 175     


Lys Gln Gln Glu Ile Pro Ser Val Phe Pro Lys Xaa Ser Ile Ser Pro 
            180                 185                 190         


Leu Asn Val Val Gln Gly Ala Ser Val Asn Ser Ser Ser Gln Xaa Ala 
        195                 200                 205             


Ala Gln Val Xaa Lys Gly Val Lys Arg Lys Ala Asp Xaa Xaa Xaa Pro 
    210                 215                 220                 


Ala Xaa Ser Ala Val Lys Ala Ser Ser Glu Phe Ser Pro Xaa Phe Xaa 
225                 230                 235                 240 


Glu Lys Ser Val Ala Leu Pro Pro Ile Lys Glu Asn Met Pro Lys Asn 
                245                 250                 255     


Val Leu Pro Asp Ser Gln Gln Gln Tyr Asn Val Val Lys Xaa Val Lys 
            260                 265                 270         


Val Xaa Glu Gln Leu Arg His Cys Ser Glu Ile Leu Lys Glu Met Leu 
        275                 280                 285             


Ala Lys Lys His Phe Ser Tyr Ala Trp Pro Phe Tyr Asn Pro Val Asp 
    290                 295                 300                 


Val Asn Ala Leu Gly Leu His Asn Tyr Tyr Asp Val Val Lys Asn Pro 
305                 310                 315                 320 


Met Asp Leu Gly Xaa Ile Lys Glu Lys Met Asp Asn Gln Glu Tyr Lys 
                325                 330                 335     


Asp Ala Tyr Lys Phe Ala Ala Asp Val Arg Leu Met Phe Met Asn Cys 
            340                 345                 350         


Tyr Lys Tyr Asn Pro Pro Asp His Glu Val Val Xaa Met Ala Arg Met 
        355                 360                 365             


Leu Gln Asp Val Phe Glu Xaa His Phe Ser Lys Ile Pro Ile Glu Pro 
    370                 375                 380                 


Val Glu Ser Met Pro Leu Cys Tyr Ile Lys Xaa Asp Ile Xaa Glu Xaa 
385                 390                 395                 400 


Xaa Gly Arg Glu Asn Xaa Asn Glu Ala Ser Ser Glu Gly Asn Ser Ser 
                405                 410                 415     


Asp Asp Ser Glu Asp Glu Arg Val Lys Arg Leu Ala Lys Leu Gln Glu 
            420                 425                 430         


Gln Leu Lys Ala Val His Gln Gln Leu Gln Val Leu Ser Gln Val Pro 
        435                 440                 445             


Phe Arg Lys Leu Asn Lys Lys Lys Glu Lys Ser Lys Lys Glu Lys Lys 
    450                 455                 460                 


Lys Glu Lys Val Asn Asn Ser Asn Glu Asn Pro Arg Lys Met Cys Glu 
465                 470                 475                 480 


Gln Met Arg Leu Lys Glu Lys Ser Lys Arg Asn Gln Pro Lys Lys Arg 
                485                 490                 495     


Lys Gln Gln Phe Ile Gly Leu Lys Ser Glu Asp Glu Asp Asn Ala Lys 
            500                 505                 510         


Pro Met Asn Tyr Asp Glu Lys Arg Gln Leu Ser Leu Asn Ile Asn Lys 
        515                 520                 525             


Leu Pro Gly Asp Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg 
    530                 535                 540                 


Glu Pro Ser Leu Ser Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe 
545                 550                 555                 560 


Glu Xaa Leu Lys Ala Ser Xaa Leu Arg Glu Leu Glu Lys Tyr Val Ser 
                565                 570                 575     


Ala Cys Leu Arg Lys Arg Pro Leu Lys Pro Pro Ala Lys Lys Ile Met 
            580                 585                 590         


Met Ser Lys Glu Glu Leu His Ser Gln Lys Lys Gln Glu Leu Glu Lys 
        595                 600                 605             


Arg Leu Leu Asp Val Asn Asn Gln Leu Asn Ser Arg Lys Arg Gln Xaa 
    610                 615                 620                 


Lys Ser Asp Lys Xaa Gln Pro Ser Lys Ala Val Glu Asn Val Ser Arg 
625                 630                 635                 640 


Leu Ser Glu Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Glu Ser 
                645                 650                 655     


Ser Ser Ser Asp Leu Ser Ser Ser Asp Ser Ser Asp Ser Glu Ser Glu 
            660                 665                 670         


Met Phe Pro Lys Phe Xaa Glu Val Lys Pro Asn Asp Ser Pro Ser Lys 
        675                 680                 685             


Glu Asn Val Lys Lys Met Lys Asn Glu Cys Ile Pro Pro Glu Gly Arg 
    690                 695                 700                 


Xaa Gly Val Xaa Gln Ile Gly Tyr Cys Val Gln Asp Xaa Xaa Ser Ala 
705                 710                 715                 720 


Asn Xaa Xaa Leu Val His Gln Xaa Xaa Pro Ser His Val Met Pro Pro 
                725                 730                 735     


Asn His His Gln Leu Ala Phe Asn Tyr Gln Glu Leu Glu His Leu Gln 
            740                 745                 750         


Xaa Val Lys Asn Ile Ser Pro Leu Gln Ile Leu Pro Pro Ser Gly Asp 
        755                 760                 765             


Ser Glu Gln Leu Ser Asn Gly Ile Xaa Val Met His Pro Ser Gly Asp 
    770                 775                 780                 


Ser Asp Xaa Xaa Met Leu Glu Ser Glu Cys Gln Ala Pro Val Gln Lys 
785                 790                 795                 800 


Asp Ile Lys Ile Lys Asn Ala Asp Ser Trp Lys Ser Leu Gly Lys Pro 
                805                 810                 815     


Val Lys Pro Ser Gly Val Met Lys Ser Ser Asp Glu Leu Phe Asn Gln 
            820                 825                 830         


Phe Arg Lys Ala Ala Ile Glu Lys Glu Val Lys Ala Arg Xaa Gln Glu 
        835                 840                 845             


Leu Ile Arg Lys His Leu Glu Gln Asn Xaa Lys Glu Leu Lys Ala Ser 
    850                 855                 860                 


Gln Glu Asn Gln Arg Asp Leu Gly Asn Gly Leu Xaa Val Glu Ser Phe 
865                 870                 875                 880 


Ser Asn Lys Ile Gln Asn Lys Cys Ser Gly Glu Glu Gln Lys Glu His 
                885                 890                 895     


Gln Gln Ser Ser Glu Ala Gln Asp Lys Ser Lys Leu Trp Leu Leu Lys 
            900                 905                 910         


Asp Arg Asp Leu Ala Arg Gln Lys Glu Gln Glu Arg Arg Arg Arg Glu 
        915                 920                 925             


Ala Met Val Gly Xaa Ile Asp Met Xaa Leu Gln Ser Asp Ile Met Xaa 
    930                 935                 940                 


Met Phe Glu Asn Asn Phe Asp 
945                 950     


<210> 4420
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 4420
Met Ser Leu Pro Ser Arg Gln Xaa Ala Ile Ile Val Asn Pro Pro Pro 
1               5                   10                  15      


Pro Glu Tyr Ile Asn Xaa Lys Lys Asn Gly Arg Leu Xaa Asn Gln Leu 
            20                  25                  30          


Gln Tyr Leu Gln Lys Val Val Leu Lys Asp Leu Trp Lys His Ser Phe 
        35                  40                  45              


Ser Trp Pro Phe Gln Arg Pro Val Asp Ala Val Lys Leu Gln Leu Pro 
    50                  55                  60                  


Asp Tyr Tyr Xaa Ile Ile Lys Asn Pro Met Asp Leu Asn Xaa Ile Lys 
65                  70                  75                  80  


Lys Arg Leu Glu Asn Lys Tyr Tyr Ala Lys Ala Ser Glu Cys Ile Glu 
                85                  90                  95      


Asp Phe Asn Xaa Met Phe Ser Asn Cys Tyr Leu Tyr Asn Lys Pro Gly 
            100                 105                 110         


Asp Asp Ile Val Leu Met Ala Gln Ala Leu Glu Lys Leu Phe Met Gln 
        115                 120                 125             


Lys Leu Ser Gln Met Pro Gln Glu Glu Gln Val Val Gly Val Lys Glu 
    130                 135                 140                 


Arg Ile Lys Lys Gly Xaa Gln Gln Asn Ile Ala 
145                 150                 155 


<210> 4421
<211> 176
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<400> 4421
Met Ser Leu Pro Ser Arg Gln Xaa Ala Ile Ile Val Asn Pro Pro Pro 
1               5                   10                  15      


Pro Glu Tyr Ile Asn Xaa Lys Lys Asn Gly Arg Leu Xaa Asn Gln Leu 
            20                  25                  30          


Gln Tyr Leu Gln Lys Val Val Leu Lys Asp Leu Trp Lys His Ser Phe 
        35                  40                  45              


Ser Trp Pro Phe Gln Arg Pro Val Asp Ala Val Lys Leu Gln Leu Pro 
    50                  55                  60                  


Asp Tyr Tyr Xaa Ile Ile Lys Asn Pro Met Asp Leu Asn Xaa Ile Lys 
65                  70                  75                  80  


Lys Arg Leu Glu Asn Lys Tyr Tyr Ala Lys Ala Ser Glu Cys Ile Glu 
                85                  90                  95      


Asp Phe Asn Xaa Met Phe Ser Asn Cys Tyr Leu Tyr Asn Lys Pro Gly 
            100                 105                 110         


Asp Asp Ile Val Leu Met Ala Gln Ala Leu Glu Lys Leu Phe Met Gln 
        115                 120                 125             


Lys Leu Ser Gln Met Pro Gln Glu Glu Gln Val Val Gly Val Lys Glu 
    130                 135                 140                 


Arg Ile Lys Lys Gly Xaa Gln Gln Asn Ile Ala Val Ser Ser Ala Lys 
145                 150                 155                 160 


Glu Lys Ser Ser Pro Ser Ala Xaa Glu Lys Val Phe Lys Gln Gln Glu 
                165                 170                 175     


<210> 4422
<211> 200
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<400> 4422
Met Ser Leu Pro Ser Arg Gln Xaa Ala Ile Ile Val Asn Pro Pro Pro 
1               5                   10                  15      


Pro Glu Tyr Ile Asn Xaa Lys Lys Asn Gly Arg Leu Xaa Asn Gln Leu 
            20                  25                  30          


Gln Tyr Leu Gln Lys Val Val Leu Lys Asp Leu Trp Lys His Ser Phe 
        35                  40                  45              


Ser Trp Pro Phe Gln Arg Pro Val Asp Ala Val Lys Leu Gln Leu Pro 
    50                  55                  60                  


Asp Tyr Tyr Xaa Ile Ile Lys Asn Pro Met Asp Leu Asn Xaa Ile Lys 
65                  70                  75                  80  


Lys Arg Leu Glu Asn Lys Tyr Tyr Ala Lys Ala Ser Glu Cys Ile Glu 
                85                  90                  95      


Asp Phe Asn Xaa Met Phe Ser Asn Cys Tyr Leu Tyr Asn Lys Pro Gly 
            100                 105                 110         


Asp Asp Ile Val Leu Met Ala Gln Ala Leu Glu Lys Leu Phe Met Gln 
        115                 120                 125             


Lys Leu Ser Gln Met Pro Gln Glu Glu Gln Val Val Gly Val Lys Glu 
    130                 135                 140                 


Arg Ile Lys Lys Gly Xaa Gln Gln Asn Ile Ala Val Ser Ser Ala Lys 
145                 150                 155                 160 


Glu Lys Ser Ser Pro Ser Ala Xaa Glu Lys Val Phe Lys Gln Gln Glu 
                165                 170                 175     


Ile Pro Ser Val Phe Pro Lys Xaa Ser Ile Ser Pro Leu Asn Val Val 
            180                 185                 190         


Gln Gly Ala Ser Val Asn Ser Ser 
        195                 200 


<210> 4423
<211> 462
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<400> 4423
Met Ser Leu Pro Ser Arg Gln Xaa Ala Ile Ile Val Asn Pro Pro Pro 
1               5                   10                  15      


Pro Glu Tyr Ile Asn Xaa Lys Lys Asn Gly Arg Leu Xaa Asn Gln Leu 
            20                  25                  30          


Gln Tyr Leu Gln Lys Val Val Leu Lys Asp Leu Trp Lys His Ser Phe 
        35                  40                  45              


Ser Trp Pro Phe Gln Arg Pro Val Asp Ala Val Lys Leu Gln Leu Pro 
    50                  55                  60                  


Asp Tyr Tyr Xaa Ile Ile Lys Asn Pro Met Asp Leu Asn Xaa Ile Lys 
65                  70                  75                  80  


Lys Arg Leu Glu Asn Lys Tyr Tyr Ala Lys Ala Ser Glu Cys Ile Glu 
                85                  90                  95      


Asp Phe Asn Xaa Met Phe Ser Asn Cys Tyr Leu Tyr Asn Lys Pro Gly 
            100                 105                 110         


Asp Asp Ile Val Leu Met Ala Gln Ala Leu Glu Lys Leu Phe Met Gln 
        115                 120                 125             


Lys Leu Ser Gln Met Pro Gln Glu Glu Gln Val Val Gly Val Lys Glu 
    130                 135                 140                 


Arg Ile Lys Lys Gly Xaa Gln Gln Asn Ile Ala Val Ser Ser Ala Lys 
145                 150                 155                 160 


Glu Lys Ser Ser Pro Ser Ala Xaa Glu Lys Val Phe Lys Gln Gln Glu 
                165                 170                 175     


Ile Pro Ser Val Phe Pro Lys Xaa Ser Ile Ser Pro Leu Asn Val Val 
            180                 185                 190         


Gln Gly Ala Ser Val Asn Ser Ser Ser Gln Xaa Ala Ala Gln Val Xaa 
        195                 200                 205             


Lys Gly Val Lys Arg Lys Ala Asp Xaa Xaa Xaa Pro Ala Xaa Ser Ala 
    210                 215                 220                 


Val Lys Ala Ser Ser Glu Phe Ser Pro Xaa Phe Xaa Glu Lys Ser Val 
225                 230                 235                 240 


Ala Leu Pro Pro Ile Lys Glu Asn Met Pro Lys Asn Val Leu Pro Asp 
                245                 250                 255     


Ser Gln Gln Gln Tyr Asn Val Val Lys Xaa Val Lys Val Xaa Glu Gln 
            260                 265                 270         


Leu Arg His Cys Ser Glu Ile Leu Lys Glu Met Leu Ala Lys Lys His 
        275                 280                 285             


Phe Ser Tyr Ala Trp Pro Phe Tyr Asn Pro Val Asp Val Asn Ala Leu 
    290                 295                 300                 


Gly Leu His Asn Tyr Tyr Asp Val Val Lys Asn Pro Met Asp Leu Gly 
305                 310                 315                 320 


Xaa Ile Lys Glu Lys Met Asp Asn Gln Glu Tyr Lys Asp Ala Tyr Lys 
                325                 330                 335     


Phe Ala Ala Asp Val Arg Leu Met Phe Met Asn Cys Tyr Lys Tyr Asn 
            340                 345                 350         


Pro Pro Asp His Glu Val Val Xaa Met Ala Arg Met Leu Gln Asp Val 
        355                 360                 365             


Phe Glu Xaa His Phe Ser Lys Ile Pro Ile Glu Pro Val Glu Ser Met 
    370                 375                 380                 


Pro Leu Cys Tyr Ile Lys Xaa Asp Ile Xaa Glu Xaa Xaa Gly Arg Glu 
385                 390                 395                 400 


Asn Xaa Asn Glu Ala Ser Ser Glu Gly Asn Ser Ser Asp Asp Ser Glu 
                405                 410                 415     


Asp Glu Arg Val Lys Arg Leu Ala Lys Leu Gln Glu Gln Leu Lys Ala 
            420                 425                 430         


Val His Gln Gln Leu Gln Val Leu Ser Gln Val Pro Phe Arg Lys Leu 
        435                 440                 445             


Asn Lys Lys Lys Glu Lys Ser Lys Lys Glu Lys Lys Lys Glu 
    450                 455                 460         


<210> 4424
<211> 947
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<400> 4424
Met Ser Leu Pro Ser Arg Gln Xaa Ala Ile Ile Val Asn Pro Pro Pro 
1               5                   10                  15      


Pro Glu Tyr Ile Asn Xaa Lys Lys Asn Gly Arg Leu Xaa Asn Gln Leu 
            20                  25                  30          


Gln Tyr Leu Gln Lys Val Val Leu Lys Asp Leu Trp Lys His Ser Phe 
        35                  40                  45              


Ser Trp Pro Phe Gln Arg Pro Val Asp Ala Val Lys Leu Gln Leu Pro 
    50                  55                  60                  


Asp Tyr Tyr Xaa Ile Ile Lys Asn Pro Met Asp Leu Asn Xaa Ile Lys 
65                  70                  75                  80  


Lys Arg Leu Glu Asn Lys Tyr Tyr Ala Lys Ala Ser Glu Cys Ile Glu 
                85                  90                  95      


Asp Phe Asn Xaa Met Phe Ser Asn Cys Tyr Leu Tyr Asn Lys Pro Gly 
            100                 105                 110         


Asp Asp Ile Val Leu Met Ala Gln Ala Leu Glu Lys Leu Phe Met Gln 
        115                 120                 125             


Lys Leu Ser Gln Met Pro Gln Glu Glu Gln Val Val Gly Val Lys Glu 
    130                 135                 140                 


Arg Ile Lys Lys Gly Xaa Gln Gln Asn Ile Ala Val Ser Ser Ala Lys 
145                 150                 155                 160 


Glu Lys Ser Ser Pro Ser Ala Xaa Glu Lys Val Phe Lys Gln Gln Glu 
                165                 170                 175     


Ile Pro Ser Val Phe Pro Lys Xaa Ser Ile Ser Pro Leu Asn Val Val 
            180                 185                 190         


Gln Gly Ala Ser Val Asn Ser Ser Ser Gln Xaa Ala Ala Gln Val Xaa 
        195                 200                 205             


Lys Gly Val Lys Arg Lys Ala Asp Xaa Xaa Xaa Pro Ala Xaa Ser Ala 
    210                 215                 220                 


Val Lys Ala Ser Ser Glu Phe Ser Pro Xaa Phe Xaa Glu Lys Ser Val 
225                 230                 235                 240 


Ala Leu Pro Pro Ile Lys Glu Asn Met Pro Lys Asn Val Leu Pro Asp 
                245                 250                 255     


Ser Gln Gln Gln Tyr Asn Val Val Lys Xaa Val Lys Val Xaa Glu Gln 
            260                 265                 270         


Leu Arg His Cys Ser Glu Ile Leu Lys Glu Met Leu Ala Lys Lys His 
        275                 280                 285             


Phe Ser Tyr Ala Trp Pro Phe Tyr Asn Pro Val Asp Val Asn Ala Leu 
    290                 295                 300                 


Gly Leu His Asn Tyr Tyr Asp Val Val Lys Asn Pro Met Asp Leu Gly 
305                 310                 315                 320 


Xaa Ile Lys Glu Lys Met Asp Asn Gln Glu Tyr Lys Asp Ala Tyr Lys 
                325                 330                 335     


Phe Ala Ala Asp Val Arg Leu Met Phe Met Asn Cys Tyr Lys Tyr Asn 
            340                 345                 350         


Pro Pro Asp His Glu Val Val Xaa Met Ala Arg Met Leu Gln Asp Val 
        355                 360                 365             


Phe Glu Xaa His Phe Ser Lys Ile Pro Ile Glu Pro Val Glu Ser Met 
    370                 375                 380                 


Pro Leu Cys Tyr Ile Lys Xaa Asp Ile Xaa Glu Xaa Xaa Gly Arg Glu 
385                 390                 395                 400 


Asn Xaa Asn Glu Ala Ser Ser Glu Gly Asn Ser Ser Asp Asp Ser Glu 
                405                 410                 415     


Asp Glu Arg Val Lys Arg Leu Ala Lys Leu Gln Glu Gln Leu Lys Ala 
            420                 425                 430         


Val His Gln Gln Leu Gln Val Leu Ser Gln Val Pro Phe Arg Lys Leu 
        435                 440                 445             


Asn Lys Lys Lys Glu Lys Ser Lys Lys Glu Lys Lys Lys Glu Lys Val 
    450                 455                 460                 


Asn Asn Ser Asn Glu Asn Pro Arg Lys Met Cys Glu Gln Met Arg Leu 
465                 470                 475                 480 


Lys Glu Lys Ser Lys Arg Asn Gln Pro Lys Lys Arg Lys Gln Gln Phe 
                485                 490                 495     


Ile Gly Leu Lys Ser Glu Asp Glu Asp Asn Ala Lys Pro Met Asn Tyr 
            500                 505                 510         


Asp Glu Lys Arg Gln Leu Ser Leu Asn Ile Asn Lys Leu Pro Gly Asp 
        515                 520                 525             


Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg Glu Pro Ser Leu 
    530                 535                 540                 


Ser Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe Glu Xaa Leu Lys 
545                 550                 555                 560 


Ala Ser Xaa Leu Arg Glu Leu Glu Lys Tyr Val Ser Ala Cys Leu Arg 
                565                 570                 575     


Lys Arg Pro Leu Lys Pro Pro Ala Lys Lys Ile Met Met Ser Lys Glu 
            580                 585                 590         


Glu Leu His Ser Gln Lys Lys Gln Glu Leu Glu Lys Arg Leu Leu Asp 
        595                 600                 605             


Val Asn Asn Gln Leu Asn Ser Arg Lys Arg Gln Xaa Lys Ser Asp Lys 
    610                 615                 620                 


Xaa Gln Pro Ser Lys Ala Val Glu Asn Val Ser Arg Leu Ser Glu Ser 
625                 630                 635                 640 


Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Glu Ser Ser Ser Ser Asp 
                645                 650                 655     


Leu Ser Ser Ser Asp Ser Ser Asp Ser Glu Ser Glu Met Phe Pro Lys 
            660                 665                 670         


Phe Xaa Glu Val Lys Pro Asn Asp Ser Pro Ser Lys Glu Asn Val Lys 
        675                 680                 685             


Lys Met Lys Asn Glu Cys Ile Pro Pro Glu Gly Arg Xaa Gly Val Xaa 
    690                 695                 700                 


Gln Ile Gly Tyr Cys Val Gln Asp Xaa Xaa Ser Ala Asn Xaa Xaa Leu 
705                 710                 715                 720 


Val His Gln Xaa Xaa Pro Ser His Val Met Pro Pro Asn His His Gln 
                725                 730                 735     


Leu Ala Phe Asn Tyr Gln Glu Leu Glu His Leu Gln Xaa Val Lys Asn 
            740                 745                 750         


Ile Ser Pro Leu Gln Ile Leu Pro Pro Ser Gly Asp Ser Glu Gln Leu 
        755                 760                 765             


Ser Asn Gly Ile Xaa Val Met His Pro Ser Gly Asp Ser Asp Xaa Xaa 
    770                 775                 780                 


Met Leu Glu Ser Glu Cys Gln Ala Pro Val Gln Lys Asp Ile Lys Ile 
785                 790                 795                 800 


Lys Asn Ala Asp Ser Trp Lys Ser Leu Gly Lys Pro Val Lys Pro Ser 
                805                 810                 815     


Gly Val Met Lys Ser Ser Asp Glu Leu Phe Asn Gln Phe Arg Lys Ala 
            820                 825                 830         


Ala Ile Glu Lys Glu Val Lys Ala Arg Xaa Gln Glu Leu Ile Arg Lys 
        835                 840                 845             


His Leu Glu Gln Asn Xaa Lys Glu Leu Lys Ala Ser Gln Glu Asn Gln 
    850                 855                 860                 


Arg Asp Leu Gly Asn Gly Leu Xaa Val Glu Ser Phe Ser Asn Lys Ile 
865                 870                 875                 880 


Gln Asn Lys Cys Ser Gly Glu Glu Gln Lys Glu His Gln Gln Ser Ser 
                885                 890                 895     


Glu Ala Gln Asp Lys Ser Lys Leu Trp Leu Leu Lys Asp Arg Asp Leu 
            900                 905                 910         


Ala Arg Gln Lys Glu Gln Glu Arg Arg Arg Arg Glu Ala Met Val Gly 
        915                 920                 925             


Xaa Ile Asp Met Xaa Leu Gln Ser Asp Ile Met Xaa Met Phe Glu Asn 
    930                 935                 940                 


Asn Phe Asp 
945         


<210> 4425
<211> 901
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<400> 4425
Met Ser Leu Pro Ser Arg Gln Xaa Ala Ile Ile Val Asn Pro Pro Pro 
1               5                   10                  15      


Pro Glu Tyr Ile Asn Xaa Lys Lys Asn Gly Arg Leu Xaa Asn Gln Leu 
            20                  25                  30          


Gln Tyr Leu Gln Lys Val Val Leu Lys Asp Leu Trp Lys His Ser Phe 
        35                  40                  45              


Ser Trp Pro Phe Gln Arg Pro Val Asp Ala Val Lys Leu Gln Leu Pro 
    50                  55                  60                  


Pro Gly Asp Asp Ile Val Leu Met Ala Gln Ala Leu Glu Lys Leu Phe 
65                  70                  75                  80  


Met Gln Lys Leu Ser Gln Met Pro Gln Glu Glu Gln Val Val Gly Val 
                85                  90                  95      


Lys Glu Arg Ile Lys Lys Gly Xaa Gln Gln Asn Ile Ala Val Ser Ser 
            100                 105                 110         


Ala Lys Glu Lys Ser Ser Pro Ser Ala Xaa Glu Lys Val Phe Lys Gln 
        115                 120                 125             


Gln Glu Ile Pro Ser Val Phe Pro Lys Xaa Ser Ile Ser Pro Leu Asn 
    130                 135                 140                 


Val Val Gln Gly Ala Ser Val Asn Ser Ser Ser Gln Xaa Ala Ala Gln 
145                 150                 155                 160 


Val Xaa Lys Gly Val Lys Arg Lys Ala Asp Xaa Xaa Xaa Pro Ala Xaa 
                165                 170                 175     


Ser Ala Val Lys Ala Ser Ser Glu Phe Ser Pro Xaa Phe Xaa Glu Lys 
            180                 185                 190         


Ser Val Ala Leu Pro Pro Ile Lys Glu Asn Met Pro Lys Asn Val Leu 
        195                 200                 205             


Pro Asp Ser Gln Gln Gln Tyr Asn Val Val Lys Xaa Val Lys Val Xaa 
    210                 215                 220                 


Glu Gln Leu Arg His Cys Ser Glu Ile Leu Lys Glu Met Leu Ala Lys 
225                 230                 235                 240 


Lys His Phe Ser Tyr Ala Trp Pro Phe Tyr Asn Pro Val Asp Val Asn 
                245                 250                 255     


Ala Leu Gly Leu His Asn Tyr Tyr Asp Val Val Lys Asn Pro Met Asp 
            260                 265                 270         


Leu Gly Xaa Ile Lys Glu Lys Met Asp Asn Gln Glu Tyr Lys Asp Ala 
        275                 280                 285             


Tyr Lys Phe Ala Ala Asp Val Arg Leu Met Phe Met Asn Cys Tyr Lys 
    290                 295                 300                 


Tyr Asn Pro Pro Asp His Glu Val Val Xaa Met Ala Arg Met Leu Gln 
305                 310                 315                 320 


Asp Val Phe Glu Xaa His Phe Ser Lys Ile Pro Ile Glu Pro Val Glu 
                325                 330                 335     


Ser Met Pro Leu Cys Tyr Ile Lys Xaa Asp Ile Xaa Glu Xaa Xaa Gly 
            340                 345                 350         


Arg Glu Asn Xaa Asn Glu Ala Ser Ser Glu Gly Asn Ser Ser Asp Asp 
        355                 360                 365             


Ser Glu Asp Glu Arg Val Lys Arg Leu Ala Lys Leu Gln Glu Gln Leu 
    370                 375                 380                 


Lys Ala Val His Gln Gln Leu Gln Val Leu Ser Gln Val Pro Phe Arg 
385                 390                 395                 400 


Lys Leu Asn Lys Lys Lys Glu Lys Ser Lys Lys Glu Lys Lys Lys Glu 
                405                 410                 415     


Lys Val Asn Asn Ser Asn Glu Asn Pro Arg Lys Met Cys Glu Gln Met 
            420                 425                 430         


Arg Leu Lys Glu Lys Ser Lys Arg Asn Gln Pro Lys Lys Arg Lys Gln 
        435                 440                 445             


Gln Phe Ile Gly Leu Lys Ser Glu Asp Glu Asp Asn Ala Lys Pro Met 
    450                 455                 460                 


Asn Tyr Asp Glu Lys Arg Gln Leu Ser Leu Asn Ile Asn Lys Leu Pro 
465                 470                 475                 480 


Gly Asp Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg Glu Pro 
                485                 490                 495     


Ser Leu Ser Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe Glu Xaa 
            500                 505                 510         


Leu Lys Ala Ser Xaa Leu Arg Glu Leu Glu Lys Tyr Val Ser Ala Cys 
        515                 520                 525             


Leu Arg Lys Arg Pro Leu Lys Pro Pro Ala Lys Lys Ile Met Met Ser 
    530                 535                 540                 


Lys Glu Glu Leu His Ser Gln Lys Lys Gln Glu Leu Glu Lys Arg Leu 
545                 550                 555                 560 


Leu Asp Val Asn Asn Gln Leu Asn Ser Arg Lys Arg Gln Xaa Lys Ser 
                565                 570                 575     


Asp Lys Xaa Gln Pro Ser Lys Ala Val Glu Asn Val Ser Arg Leu Ser 
            580                 585                 590         


Glu Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Glu Ser Ser Ser 
        595                 600                 605             


Ser Asp Leu Ser Ser Ser Asp Ser Ser Asp Ser Glu Ser Glu Met Phe 
    610                 615                 620                 


Pro Lys Phe Xaa Glu Val Lys Pro Asn Asp Ser Pro Ser Lys Glu Asn 
625                 630                 635                 640 


Val Lys Lys Met Lys Asn Glu Cys Ile Pro Pro Glu Gly Arg Xaa Gly 
                645                 650                 655     


Val Xaa Gln Ile Gly Tyr Cys Val Gln Asp Xaa Xaa Ser Ala Asn Xaa 
            660                 665                 670         


Xaa Leu Val His Gln Xaa Xaa Pro Ser His Val Met Pro Pro Asn His 
        675                 680                 685             


His Gln Leu Ala Phe Asn Tyr Gln Glu Leu Glu His Leu Gln Xaa Val 
    690                 695                 700                 


Lys Asn Ile Ser Pro Leu Gln Ile Leu Pro Pro Ser Gly Asp Ser Glu 
705                 710                 715                 720 


Gln Leu Ser Asn Gly Ile Xaa Val Met His Pro Ser Gly Asp Ser Asp 
                725                 730                 735     


Xaa Xaa Met Leu Glu Ser Glu Cys Gln Ala Pro Val Gln Lys Asp Ile 
            740                 745                 750         


Lys Ile Lys Asn Ala Asp Ser Trp Lys Ser Leu Gly Lys Pro Val Lys 
        755                 760                 765             


Pro Ser Gly Val Met Lys Ser Ser Asp Glu Leu Phe Asn Gln Phe Arg 
    770                 775                 780                 


Lys Ala Ala Ile Glu Lys Glu Val Lys Ala Arg Xaa Gln Glu Leu Ile 
785                 790                 795                 800 


Arg Lys His Leu Glu Gln Asn Xaa Lys Glu Leu Lys Ala Ser Gln Glu 
                805                 810                 815     


Asn Gln Arg Asp Leu Gly Asn Gly Leu Xaa Val Glu Ser Phe Ser Asn 
            820                 825                 830         


Lys Ile Gln Asn Lys Cys Ser Gly Glu Glu Gln Lys Glu His Gln Gln 
        835                 840                 845             


Ser Ser Glu Ala Gln Asp Lys Ser Lys Leu Trp Leu Leu Lys Asp Arg 
    850                 855                 860                 


Asp Leu Ala Arg Gln Lys Glu Gln Glu Arg Arg Arg Arg Glu Ala Met 
865                 870                 875                 880 


Val Gly Xaa Ile Asp Met Xaa Leu Gln Ser Asp Ile Met Xaa Met Phe 
                885                 890                 895     


Glu Asn Asn Phe Asp 
            900     


<210> 4426
<211> 153
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<400> 4426
Met Ser Pro Glu Val Ala Leu Asn Arg Ile Ser Pro Met Leu Ser Pro 
1               5                   10                  15      


Phe Ile Ser Ser Val Val Arg Asn Gly Lys Val Gly Leu Asp Ala Xaa 
            20                  25                  30          


Asn Cys Leu Arg Ile Xaa Asp Leu Lys Ser Gly Cys Xaa Ser Leu Xaa 
        35                  40                  45              


Pro Gly Pro Asn Cys Asp Arg Phe Lys Leu His Ile Pro Tyr Ala Gly 
    50                  55                  60                  


Glu Xaa Leu Lys Trp Asp Ile Ile Phe Asn Ala Gln Tyr Pro Glu Leu 
65                  70                  75                  80  


Pro Pro Asp Phe Ile Phe Gly Glu Asp Ala Glu Phe Leu Pro Asp Pro 
                85                  90                  95      


Ser Ala Leu Gln Asn Leu Ala Ser Trp Asn Pro Ser Asn Pro Glu Cys 
            100                 105                 110         


Leu Leu Leu Val Val Lys Glu Leu Val Gln Gln Tyr His Gln Phe Gln 
        115                 120                 125             


Cys Ser Arg Leu Arg Glu Ser Ser Arg Leu Met Phe Glu Tyr Gln Xaa 
    130                 135                 140                 


Leu Leu Glu Glu Pro Gln Tyr Gly Glu 
145                 150             


<210> 4427
<211> 376
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<400> 4427
Met Ser Pro Glu Val Ala Leu Asn Arg Ile Ser Pro Met Leu Ser Pro 
1               5                   10                  15      


Phe Ile Ser Ser Val Val Arg Asn Gly Lys Val Gly Leu Asp Ala Xaa 
            20                  25                  30          


Asn Cys Leu Arg Ile Xaa Asp Leu Lys Ser Gly Cys Xaa Ser Leu Xaa 
        35                  40                  45              


Pro Gly Pro Asn Cys Asp Arg Phe Lys Leu His Ile Pro Tyr Ala Gly 
    50                  55                  60                  


Glu Xaa Leu Lys Trp Asp Ile Ile Phe Asn Ala Gln Tyr Pro Glu Leu 
65                  70                  75                  80  


Pro Pro Asp Phe Ile Phe Gly Glu Asp Ala Glu Phe Leu Pro Asp Pro 
                85                  90                  95      


Ser Ala Leu Gln Asn Leu Ala Ser Trp Asn Pro Ser Asn Pro Glu Cys 
            100                 105                 110         


Leu Leu Leu Val Val Lys Glu Leu Val Gln Gln Tyr His Gln Phe Gln 
        115                 120                 125             


Cys Ser Arg Leu Arg Glu Ser Ser Arg Leu Met Phe Glu Tyr Gln Xaa 
    130                 135                 140                 


Leu Leu Glu Glu Pro Gln Tyr Gly Glu Asn Met Glu Ile Tyr Ala Gly 
145                 150                 155                 160 


Lys Lys Asn Asn Trp Xaa Gly Glu Phe Ser Ala Arg Phe Leu Leu Lys 
                165                 170                 175     


Leu Pro Val Asp Phe Ser Asn Ile Pro Xaa Tyr Leu Leu Lys Asp Val 
            180                 185                 190         


Asn Glu Asp Pro Gly Glu Asp Val Ala Leu Leu Ser Val Ser Phe Glu 
        195                 200                 205             


Asp Xaa Glu Ala Xaa Gln Val Tyr Pro Lys Leu Tyr Leu Ser Pro Arg 
    210                 215                 220                 


Ile Glu His Ala Leu Gly Gly Ser Ser Ala Leu His Ile Pro Ala Phe 
225                 230                 235                 240 


Pro Gly Gly Gly Cys Leu Ile Asp Tyr Val Pro Gln Val Cys His Leu 
                245                 250                 255     


Leu Xaa Asn Lys Val Gln Tyr Val Ile Gln Gly Tyr His Lys Arg Arg 
            260                 265                 270         


Glu Tyr Ile Ala Ala Phe Leu Ser His Phe Gly Xaa Gly Val Val Glu 
        275                 280                 285             


Tyr Asp Ala Glu Gly Phe Xaa Lys Leu Xaa Leu Leu Leu Met Trp Lys 
    290                 295                 300                 


Asp Phe Cys Phe Leu Val His Ile Asp Leu Pro Leu Phe Phe Pro Arg 
305                 310                 315                 320 


Asp Gln Pro Xaa Leu Xaa Phe Gln Ser Val Tyr His Phe Xaa Asn Ser 
                325                 330                 335     


Gly Gln Leu Tyr Ser Gln Ala Gln Lys Asn Tyr Pro Tyr Ser Pro Arg 
            340                 345                 350         


Trp Asp Gly Asn Glu Met Ala Lys Arg Ala Lys Arg Glu Ser Asn Arg 
        355                 360                 365             


Asp Gly Glu Glu Ser Ser Ser Ala 
    370                 375     


<210> 4428
<211> 383
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<400> 4428
Met Ser Pro Glu Val Ala Leu Asn Arg Ile Ser Pro Met Leu Ser Pro 
1               5                   10                  15      


Phe Ile Ser Ser Val Val Arg Asn Gly Lys Val Gly Leu Asp Ala Xaa 
            20                  25                  30          


Asn Cys Leu Arg Ile Xaa Asp Leu Lys Ser Gly Cys Xaa Ser Leu Xaa 
        35                  40                  45              


Pro Gly Pro Asn Cys Asp Arg Phe Lys Leu His Ile Pro Tyr Ala Gly 
    50                  55                  60                  


Glu Xaa Leu Lys Trp Asp Ile Ile Phe Asn Ala Gln Tyr Pro Glu Leu 
65                  70                  75                  80  


Pro Pro Asp Phe Ile Phe Gly Glu Asp Ala Glu Phe Leu Pro Asp Pro 
                85                  90                  95      


Ser Ala Leu Gln Asn Leu Ala Ser Trp Asn Pro Ser Asn Pro Glu Cys 
            100                 105                 110         


Leu Leu Leu Val Val Lys Glu Leu Val Gln Gln Tyr His Gln Phe Gln 
        115                 120                 125             


Cys Ser Arg Leu Arg Glu Ser Ser Arg Leu Met Phe Glu Tyr Gln Xaa 
    130                 135                 140                 


Leu Leu Glu Glu Pro Gln Tyr Gly Glu Asn Met Glu Ile Tyr Ala Gly 
145                 150                 155                 160 


Lys Lys Asn Asn Trp Xaa Gly Glu Phe Ser Ala Arg Phe Leu Leu Lys 
                165                 170                 175     


Leu Pro Val Asp Phe Ser Asn Ile Pro Xaa Tyr Leu Leu Lys Asp Val 
            180                 185                 190         


Asn Glu Asp Pro Gly Glu Asp Val Ala Leu Leu Ser Val Ser Phe Glu 
        195                 200                 205             


Asp Xaa Glu Ala Xaa Gln Val Tyr Pro Lys Leu Tyr Leu Ser Pro Arg 
    210                 215                 220                 


Ile Glu His Ala Leu Gly Gly Ser Ser Ala Leu His Ile Pro Ala Phe 
225                 230                 235                 240 


Pro Gly Gly Gly Cys Leu Ile Asp Tyr Val Pro Gln Val Cys His Leu 
                245                 250                 255     


Leu Xaa Asn Lys Val Gln Tyr Val Ile Gln Gly Tyr His Lys Arg Arg 
            260                 265                 270         


Glu Tyr Ile Ala Ala Phe Leu Ser His Phe Gly Xaa Gly Val Val Glu 
        275                 280                 285             


Tyr Asp Ala Glu Gly Phe Xaa Lys Leu Xaa Leu Leu Leu Met Trp Lys 
    290                 295                 300                 


Asp Phe Cys Phe Leu Val His Ile Asp Leu Pro Leu Phe Phe Pro Arg 
305                 310                 315                 320 


Asp Gln Pro Xaa Leu Xaa Phe Gln Ser Val Tyr His Phe Xaa Asn Ser 
                325                 330                 335     


Gly Gln Leu Tyr Ser Gln Ala Gln Lys Asn Tyr Pro Tyr Ser Pro Arg 
            340                 345                 350         


Trp Asp Gly Asn Glu Met Ala Lys Arg Ala Lys Ala Tyr Phe Lys Xaa 
        355                 360                 365             


Phe Val Pro Gln Phe Gln Glu Ala Ala Phe Ala Asn Gly Lys Leu 
    370                 375                 380             


<210> 4429
<211> 415
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<400> 4429
Met Ser Pro Glu Val Ala Leu Asn Arg Ile Ser Pro Met Leu Ser Pro 
1               5                   10                  15      


Phe Ile Ser Ser Val Val Arg Asn Gly Lys Val Gly Leu Asp Ala Xaa 
            20                  25                  30          


Asn Cys Leu Arg Ile Xaa Asp Leu Lys Ser Gly Cys Xaa Ser Leu Xaa 
        35                  40                  45              


Pro Gly Pro Asn Cys Asp Arg Phe Lys Leu His Ile Pro Tyr Ala Gly 
    50                  55                  60                  


Glu Xaa Leu Lys Trp Asp Ile Ile Phe Asn Ala Gln Tyr Pro Glu Leu 
65                  70                  75                  80  


Pro Pro Asp Phe Ile Phe Gly Glu Asp Ala Glu Phe Leu Pro Asp Pro 
                85                  90                  95      


Ser Ala Leu Gln Asn Leu Ala Ser Trp Asn Pro Ser Asn Pro Glu Cys 
            100                 105                 110         


Leu Leu Leu Val Val Lys Glu Leu Val Gln Gln Tyr His Gln Phe Gln 
        115                 120                 125             


Cys Ser Arg Leu Arg Glu Ser Ser Arg Leu Met Phe Glu Tyr Gln Xaa 
    130                 135                 140                 


Leu Leu Glu Glu Pro Gln Tyr Gly Glu Asn Met Glu Ile Tyr Ala Gly 
145                 150                 155                 160 


Lys Lys Asn Asn Trp Xaa Gly Glu Phe Ser Ala Arg Phe Leu Leu Lys 
                165                 170                 175     


Leu Pro Val Asp Phe Ser Asn Ile Pro Xaa Tyr Leu Leu Lys Asp Val 
            180                 185                 190         


Asn Glu Asp Pro Gly Glu Asp Val Ala Leu Leu Ser Val Ser Phe Glu 
        195                 200                 205             


Asp Xaa Glu Ala Xaa Gln Val Tyr Pro Lys Leu Tyr Leu Ser Pro Arg 
    210                 215                 220                 


Ile Glu His Ala Leu Gly Gly Ser Ser Ala Leu His Ile Pro Ala Phe 
225                 230                 235                 240 


Pro Gly Gly Gly Cys Leu Ile Asp Tyr Val Pro Gln Val Cys His Leu 
                245                 250                 255     


Leu Xaa Asn Lys Val Gln Tyr Val Ile Gln Gly Tyr His Lys Arg Arg 
            260                 265                 270         


Glu Tyr Ile Ala Ala Phe Leu Ser His Phe Gly Xaa Gly Val Val Glu 
        275                 280                 285             


Tyr Asp Ala Glu Gly Phe Xaa Lys Leu Xaa Leu Leu Leu Met Trp Lys 
    290                 295                 300                 


Asp Phe Cys Phe Leu Val His Ile Asp Leu Pro Leu Phe Phe Pro Arg 
305                 310                 315                 320 


Asp Gln Pro Xaa Leu Xaa Phe Gln Ser Val Tyr His Phe Xaa Asn Ser 
                325                 330                 335     


Gly Gln Leu Tyr Ser Gln Ala Gln Lys Asn Tyr Pro Tyr Ser Pro Arg 
            340                 345                 350         


Trp Asp Gly Asn Glu Met Ala Lys Arg Ala Lys Gly Cys Gln Gly Ser 
        355                 360                 365             


Arg Asp Ala Cys Ser Pro Trp Glu Gln Val Leu Ala Phe Ala Val Ala 
    370                 375                 380                 


Lys Xaa Gly Cys Lys Leu Leu Gln Pro Gln Arg Asn Trp Pro Ser Ser 
385                 390                 395                 400 


Arg Gly Pro Pro Trp Arg Ala Ser Glu Gly Glu Arg Xaa Ala Gln 
                405                 410                 415 


<210> 4430
<211> 284
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<400> 4430
Met Ser Pro Glu Val Ala Leu Asn Arg Ile Ser Pro Met Leu Ser Pro 
1               5                   10                  15      


Phe Ile Ser Ser Val Val Arg Asn Gly Lys Val Gly Leu Asp Ala Xaa 
            20                  25                  30          


Asn Cys Leu Arg Ile Xaa Asp Leu Lys Ser Gly Cys Xaa Ser Leu Xaa 
        35                  40                  45              


Pro Gly Pro Asn Cys Asp Arg Phe Lys Leu His Ile Pro Tyr Ala Gly 
    50                  55                  60                  


Glu Xaa Leu Lys Trp Asp Ile Ile Phe Asn Ala Gln Tyr Pro Glu Leu 
65                  70                  75                  80  


Pro Pro Asp Phe Ile Phe Gly Glu Asp Ala Glu Phe Leu Pro Asp Pro 
                85                  90                  95      


Ser Ala Leu Gln Asn Leu Ala Ser Trp Asn Pro Ser Asn Pro Glu Cys 
            100                 105                 110         


Leu Leu Leu Val Val Lys Glu Leu Val Gln Gln Tyr His Gln Phe Gln 
        115                 120                 125             


Cys Ser Arg Leu Arg Glu Ser Ser Arg Leu Met Phe Glu Tyr Gln Xaa 
    130                 135                 140                 


Leu Leu Glu Glu Pro Gln Tyr Gly Glu Asn Met Glu Ile Tyr Ala Gly 
145                 150                 155                 160 


Lys Lys Asn Asn Trp Xaa Gly Glu Phe Ser Ala Arg Phe Leu Leu Lys 
                165                 170                 175     


Leu Pro Val Asp Phe Ser Asn Ile Pro Xaa Tyr Leu Leu Lys Asp Val 
            180                 185                 190         


Asn Glu Asp Pro Gly Glu Asp Val Ala Leu Leu Ser Val Ser Phe Glu 
        195                 200                 205             


Asp Xaa Glu Ala Xaa Gln Val Tyr Pro Lys Leu Tyr Leu Ser Pro Arg 
    210                 215                 220                 


Ile Glu Gln Leu Ser Leu Ser Pro Cys His Xaa Asp Phe Leu Leu Xaa 
225                 230                 235                 240 


Arg Phe Leu Pro Ala Pro Leu Trp Gly Ser Glu Val Ser Val Pro Ser 
                245                 250                 255     


Gly Pro Phe His Leu Leu Ile Ile Leu Pro Gln Pro Leu Ser Gly Leu 
            260                 265                 270         


Val Arg Pro Cys Leu Leu Phe Ser Gln Pro Cys Ser 
        275                 280                 


<210> 4431
<211> 166
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<400> 4431
Val Arg Asn Gly Lys Val Gly Leu Asp Ala Xaa Asn Cys Leu Arg Ile 
1               5                   10                  15      


Xaa Asp Leu Lys Ser Gly Cys Xaa Ser Leu Xaa Pro Gly Pro Asn Cys 
            20                  25                  30          


Asp Arg Phe Lys Leu His Ile Pro Tyr Ala Gly Glu Xaa Leu Lys Trp 
        35                  40                  45              


Asp Ile Ile Phe Asn Ala Gln Tyr Pro Glu Leu Pro Pro Asp Phe Ile 
    50                  55                  60                  


Phe Gly Glu Asp Ala Glu Phe Leu Pro Asp Pro Ser Ala Leu Gln Asn 
65                  70                  75                  80  


Leu Ala Ser Trp Asn Pro Ser Asn Pro Glu Cys Leu Leu Leu Val Val 
                85                  90                  95      


Lys Glu Leu Val Gln Gln Tyr His Gln Phe Gln Cys Ser Arg Leu Arg 
            100                 105                 110         


Glu Ser Ser Arg Leu Met Phe Glu Tyr Gln Xaa Leu Leu Glu Glu Pro 
        115                 120                 125             


Gln Tyr Gly Glu Asn Met Glu Ile Tyr Ala Gly Lys Lys Asn Asn Trp 
    130                 135                 140                 


Val Arg Ile Phe Glu Asn Gly Lys Lys Asp Asp Phe Ile His Asn Lys 
145                 150                 155                 160 


Ile Ile Asn Ser Tyr Val 
                165     


<210> 4432
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<400> 4432
Met Pro Gly Arg Gly Arg Cys Pro Asp Cys Gly Ser Xaa Glu Leu Val 
1               5                   10                  15      


Glu Asp Ser His Tyr Ser Gln Ser Gln Leu Val Cys Ser Asp Cys Gly 
            20                  25                  30          


Cys Val Val Xaa Glu Gly Val Leu Xaa Xaa Xaa Phe Ser Asp Glu Gly 
        35                  40                  45              


Asn Leu Arg Glu Val Xaa Tyr Ser Arg Ser Xaa Gly Glu Asn Glu Gln 
    50                  55                  60                  


Val Ser Arg Ser Gln Gln Arg Glu 
65                  70          


<210> 4433
<211> 419
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<400> 4433
Met Pro Gly Arg Gly Arg Cys Pro Asp Cys Gly Ser Xaa Glu Leu Val 
1               5                   10                  15      


Glu Asp Ser His Tyr Ser Gln Ser Gln Leu Val Cys Ser Asp Cys Gly 
            20                  25                  30          


Cys Val Val Xaa Glu Gly Val Leu Xaa Xaa Xaa Phe Ser Asp Glu Gly 
        35                  40                  45              


Asn Leu Arg Glu Val Xaa Tyr Ser Arg Ser Xaa Gly Glu Asn Glu Gln 
    50                  55                  60                  


Val Ser Arg Ser Gln Gln Arg Gly Leu Arg Arg Val Arg Asp Leu Cys 
65                  70                  75                  80  


Arg Val Leu Gln Leu Pro Pro Xaa Phe Glu Asp Xaa Ala Val Ala Tyr 
                85                  90                  95      


Tyr Gln Gln Ala Tyr Arg His Ser Gly Ile Arg Ala Ala Arg Leu Gln 
            100                 105                 110         


Lys Lys Glu Val Leu Val Gly Cys Cys Val Leu Ile Xaa Cys Arg Gln 
        115                 120                 125             


His Asn Trp Pro Leu Xaa Met Gly Ala Ile Cys Xaa Leu Leu Tyr Ala 
    130                 135                 140                 


Asp Leu Asp Val Phe Ser Ser Xaa Tyr Met Gln Ile Val Lys Leu Leu 
145                 150                 155                 160 


Gly Leu Asp Val Pro Ser Leu Cys Leu Ala Glu Leu Val Lys Xaa Tyr 
                165                 170                 175     


Cys Ser Ser Phe Lys Leu Phe Gln Ala Ser Pro Ser Val Pro Ala Lys 
            180                 185                 190         


Tyr Val Glu Asp Lys Glu Lys Met Leu Ser Arg Xaa Met Gln Leu Val 
        195                 200                 205             


Glu Leu Ala Asn Glu Xaa Trp Leu Val Xaa Gly Arg His Pro Leu Pro 
    210                 215                 220                 


Val Ile Xaa Ala Ala Xaa Phe Leu Ala Trp Gln Ser Leu Gln Pro Ala 
225                 230                 235                 240 


Asp Arg Leu Ser Cys Ser Leu Ala Arg Phe Cys Lys Leu Ala Asn Val 
                245                 250                 255     


Asp Leu Pro Tyr Pro Ala Ser Ser Arg Leu Gln Glu Leu Leu Ala Val 
            260                 265                 270         


Leu Leu Arg Met Ala Glu Gln Leu Ala Trp Leu Arg Val Leu Arg Leu 
        275                 280                 285             


Asp Lys Arg Ser Val Val Lys His Ile Gly Asp Leu Leu Gln His Arg 
    290                 295                 300                 


Gln Ser Leu Val Arg Ser Ala Phe Arg Asp Gly Xaa Ala Glu Val Glu 
305                 310                 315                 320 


Xaa Arg Glu Lys Glu Pro Pro Gly Trp Gly Gln Gly Gln Gly Glu Gly 
                325                 330                 335     


Glu Val Gly Asn Asn Ser Leu Gly Leu Pro Gln Gly Lys Arg Pro Ala 
            340                 345                 350         


Ser Pro Ala Leu Leu Leu Pro Pro Cys Met Leu Lys Ser Pro Lys Arg 
        355                 360                 365             


Ile Cys Pro Val Pro Pro Val Ser Xaa Val Xaa Gly Asp Glu Asn Ile 
    370                 375                 380                 


Ser Asp Ser Glu Ile Glu Gln Tyr Leu Arg Xaa Pro Gln Glu Val Arg 
385                 390                 395                 400 


Asp Phe Gln Arg Ala Gln Ala Ala Arg Gln Ala Ala Xaa Ser Val Pro 
                405                 410                 415     


Asn Pro Pro 
            


<210> 4434
<211> 202
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<400> 4434
Met Pro Gly Arg Gly Arg Cys Pro Asp Cys Gly Ser Xaa Glu Leu Val 
1               5                   10                  15      


Glu Asp Ser His Tyr Ser Gln Ser Gln Leu Val Cys Ser Asp Cys Gly 
            20                  25                  30          


Cys Val Val Xaa Glu Gly Val Leu Xaa Xaa Xaa Phe Ser Asp Glu Gly 
        35                  40                  45              


Asn Leu Arg Glu Val Xaa Tyr Ser Arg Ser Xaa Gly Glu Asn Glu Gln 
    50                  55                  60                  


Val Ser Arg Ser Gln Gln Arg Gly Leu Arg Arg Val Arg Asp Leu Cys 
65                  70                  75                  80  


Arg Val Leu Gln Leu Pro Pro Xaa Phe Glu Asp Xaa Ala Val Ala Tyr 
                85                  90                  95      


Tyr Gln Gln Ala Tyr Arg His Ser Gly Ile Arg Ala Ala Arg Leu Gln 
            100                 105                 110         


Lys Lys Glu Val Leu Val Gly Cys Cys Val Leu Ile Xaa Cys Arg Gln 
        115                 120                 125             


His Asn Trp Pro Leu Xaa Met Gly Ala Ile Cys Xaa Leu Leu Tyr Ala 
    130                 135                 140                 


Asp Leu Asp Val Phe Ser Ser Xaa Tyr Met Gln Ile Val Lys Leu Leu 
145                 150                 155                 160 


Gly Leu Asp Val Pro Ser Leu Cys Leu Ala Glu Leu Val Lys Xaa Tyr 
                165                 170                 175     


Cys Ser Ser Leu Glu Cys Ser Gly Xaa Ile Ile Ala His Cys Ser Leu 
            180                 185                 190         


Glu Leu Met Gly Ser Ser Asp Leu Pro Xaa 
        195                 200         


<210> 4435
<211> 69
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<400> 4435
Met Ser Ser Met Trp Ser Glu Tyr Xaa Ile Gly Gly Val Lys Ile Tyr 
1               5                   10                  15      


Phe Pro Tyr Lys Ala Tyr Pro Ser Gln Leu Ala Met Met Asn Ser Ile 
            20                  25                  30          


Leu Arg Gly Leu Asn Ser Lys Gln His Cys Leu Leu Glu Ser Pro Xaa 
        35                  40                  45              


Gly Ser Gly Lys Ser Leu Ala Leu Leu Cys Ser Ala Leu Ala Trp Gln 
    50                  55                  60                  


Gln Ser Leu Ser Gly 
65                  


<210> 4436
<211> 994
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (873)..(873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<400> 4436
Met Ser Ser Met Trp Ser Glu Tyr Xaa Ile Gly Gly Val Lys Ile Tyr 
1               5                   10                  15      


Phe Pro Tyr Lys Ala Tyr Pro Ser Gln Leu Ala Met Met Asn Ser Ile 
            20                  25                  30          


Leu Arg Gly Leu Asn Ser Lys Gln His Cys Leu Leu Glu Ser Pro Xaa 
        35                  40                  45              


Gly Ser Gly Lys Ser Leu Ala Leu Leu Cys Ser Ala Leu Ala Trp Gln 
    50                  55                  60                  


Gln Ser Leu Ser Gly Lys Pro Ala Asp Glu Gly Val Ser Glu Lys Ala 
65                  70                  75                  80  


Glu Val Gln Leu Ser Cys Cys Cys Ala Cys His Ser Lys Asp Phe Xaa 
                85                  90                  95      


Asn Asn Asp Met Asn Gln Gly Xaa Ser Arg His Phe Asn Tyr Pro Ser 
            100                 105                 110         


Xaa Pro Pro Ser Glu Arg Asn Gly Xaa Ser Ser Xaa Cys Gln Asp Ser 
        115                 120                 125             


Pro Glu Lys Xaa Xaa Leu Ala Ala Lys Leu Ser Ala Lys Lys Gln Ala 
    130                 135                 140                 


Ser Ile Tyr Arg Asp Glu Asn Asp Asp Phe Gln Val Glu Lys Lys Arg 
145                 150                 155                 160 


Ile Arg Pro Leu Glu Xaa Xaa Gln Gln Ile Arg Lys Arg His Cys Phe 
                165                 170                 175     


Gly Xaa Glu Val His Asn Leu Asp Ala Lys Val Asp Ser Gly Lys Xaa 
            180                 185                 190         


Val Lys Leu Asn Ser Pro Leu Glu Lys Ile Asn Ser Phe Ser Pro Gln 
        195                 200                 205             


Lys Pro Pro Gly His Cys Ser Arg Cys Cys Cys Ser Xaa Lys Gln Gly 
    210                 215                 220                 


Asn Ser Gln Glu Ser Ser Asn Xaa Ile Lys Lys Asp His Xaa Gly Lys 
225                 230                 235                 240 


Ser Lys Ile Pro Lys Ile Tyr Phe Gly Xaa Arg Xaa His Lys Gln Ile 
                245                 250                 255     


Ala Gln Ile Xaa Arg Glu Leu Arg Arg Xaa Ala Tyr Ser Gly Val Pro 
            260                 265                 270         


Met Xaa Ile Leu Ser Ser Arg Asp His Xaa Cys Val His Pro Glu Val 
        275                 280                 285             


Val Gly Asn Phe Asn Arg Asn Glu Lys Cys Met Glu Leu Leu Asp Gly 
    290                 295                 300                 


Lys Asn Gly Lys Ser Cys Tyr Phe Tyr His Gly Val His Lys Ile Ser 
305                 310                 315                 320 


Asp Gln His Xaa Leu Gln Xaa Phe Gln Gly Met Cys Lys Ala Trp Asp 
                325                 330                 335     


Ile Glu Glu Leu Val Ser Leu Gly Lys Lys Leu Lys Ala Cys Pro Tyr 
            340                 345                 350         


Tyr Xaa Ala Arg Glu Leu Ile Gln Asp Ala Asp Ile Ile Phe Cys Pro 
        355                 360                 365             


Tyr Asn Tyr Leu Leu Asp Ala Gln Ile Arg Glu Ser Met Asp Leu Asn 
    370                 375                 380                 


Leu Lys Glu Gln Val Val Ile Leu Asp Glu Ala His Asn Ile Glu Asp 
385                 390                 395                 400 


Cys Ala Arg Glu Ser Ala Ser Tyr Ser Val Xaa Glu Val Gln Leu Arg 
                405                 410                 415     


Phe Ala Arg Asp Glu Leu Asp Ser Met Val Asn Asn Asn Ile Arg Lys 
            420                 425                 430         


Lys Asp His Glu Pro Leu Arg Ala Val Cys Cys Ser Leu Ile Asn Trp 
        435                 440                 445             


Leu Glu Ala Asn Ala Glu Tyr Leu Val Glu Arg Asp Tyr Glu Ser Ala 
    450                 455                 460                 


Cys Lys Ile Trp Ser Gly Asn Glu Met Leu Leu Xaa Leu His Lys Met 
465                 470                 475                 480 


Gly Ile Xaa Xaa Ala Xaa Phe Pro Ile Leu Gln Gly His Phe Ser Ala 
                485                 490                 495     


Val Leu Gln Lys Glu Glu Lys Ile Ser Pro Ile Tyr Gly Lys Glu Glu 
            500                 505                 510         


Ala Arg Glu Val Pro Val Ile Ser Ala Ser Xaa Gln Ile Met Leu Lys 
        515                 520                 525             


Gly Leu Phe Met Val Leu Asp Tyr Leu Phe Arg Gln Asn Ser Arg Phe 
    530                 535                 540                 


Ala Asp Asp Tyr Lys Ile Ala Ile Gln Gln Xaa Tyr Ser Trp Xaa Asn 
545                 550                 555                 560 


Gln Ile Asp Ile Ser Asp Lys Asn Gly Leu Leu Val Leu Pro Lys Asn 
                565                 570                 575     


Lys Lys Arg Ser Arg Gln Lys Xaa Ala Val His Val Leu Asn Phe Trp 
            580                 585                 590         


Cys Leu Asn Pro Ala Val Ala Phe Ser Asp Ile Asn Gly Lys Val Gln 
        595                 600                 605             


Xaa Ile Val Leu Xaa Ser Gly Xaa Leu Ser Pro Met Lys Ser Phe Ser 
    610                 615                 620                 


Ser Glu Leu Gly Val Xaa Phe Xaa Ile Gln Leu Glu Ala Asn His Ile 
625                 630                 635                 640 


Ile Lys Asn Ser Gln Val Trp Val Gly Xaa Ile Gly Ser Gly Pro Lys 
                645                 650                 655     


Gly Arg Asn Leu Cys Ala Xaa Phe Gln Asn Xaa Glu Xaa Phe Glu Phe 
            660                 665                 670         


Gln Asp Glu Val Gly Ala Leu Leu Leu Ser Val Cys Gln Xaa Val Ser 
        675                 680                 685             


Gln Gly Ile Leu Cys Phe Leu Pro Ser Tyr Lys Leu Leu Glu Lys Leu 
    690                 695                 700                 


Lys Glu Arg Trp Leu Ser Xaa Gly Leu Trp His Asn Leu Glu Leu Val 
705                 710                 715                 720 


Lys Xaa Val Ile Val Glu Pro Gln Gly Gly Glu Lys Xaa Asn Phe Asp 
                725                 730                 735     


Glu Leu Leu Gln Val Tyr Tyr Asp Ala Ile Lys Tyr Lys Gly Glu Lys 
            740                 745                 750         


Asp Gly Ala Leu Leu Val Ala Val Cys Arg Gly Lys Val Ser Glu Gly 
        755                 760                 765             


Leu Asp Phe Ser Asp Asp Asn Ala Arg Ala Val Ile Xaa Ile Gly Ile 
    770                 775                 780                 


Pro Phe Pro Asn Val Lys Asp Leu Gln Val Glu Leu Lys Arg Gln Tyr 
785                 790                 795                 800 


Asn Asp His His Ser Lys Leu Arg Gly Leu Leu Pro Gly Arg Gln Trp 
                805                 810                 815     


Tyr Glu Ile Gln Ala Tyr Arg Ala Leu Asn Gln Ala Leu Gly Arg Cys 
            820                 825                 830         


Ile Arg His Arg Asn Asp Trp Gly Ala Leu Ile Leu Val Asp Asp Arg 
        835                 840                 845             


Phe Arg Asn Asn Pro Ser Arg Tyr Ile Ser Gly Leu Ser Lys Trp Val 
    850                 855                 860                 


Arg Gln Gln Ile Gln His His Ser Xaa Phe Glu Ser Ala Leu Glu Ser 
865                 870                 875                 880 


Leu Ala Glu Phe Ser Lys Lys His Gln Lys Val Leu Asn Val Ser Ile 
                885                 890                 895     


Lys Asp Arg Xaa Asn Ile Gln Asp Asn Glu Ser Xaa Leu Glu Val Xaa 
            900                 905                 910         


Ser Leu Lys Tyr Ser Xaa Ser Pro Tyr Leu Leu Glu Ala Ala Ser His 
        915                 920                 925             


Leu Ser Pro Glu Asn Phe Val Glu Asp Glu Ala Lys Ile Cys Val Gln 
    930                 935                 940                 


Glu Leu Gln Cys Pro Lys Ile Ile Xaa Lys Asn Ser Pro Leu Pro Ser 
945                 950                 955                 960 


Ser Ile Ile Ser Arg Lys Glu Lys Ser Met Lys Ser Ser Ser His Leu 
                965                 970                 975     


Pro Leu Ile Glu Lys Ser Phe Ile Ile Phe Ser Glu Met Ile Phe Ile 
            980                 985                 990         


Trp Val 
        


<210> 4437
<211> 1249
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (873)..(873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1123)..(1123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1152)..(1152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1193)..(1193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1226)..(1226)
<223> Selenocysteine

<400> 4437
Met Ser Ser Met Trp Ser Glu Tyr Xaa Ile Gly Gly Val Lys Ile Tyr 
1               5                   10                  15      


Phe Pro Tyr Lys Ala Tyr Pro Ser Gln Leu Ala Met Met Asn Ser Ile 
            20                  25                  30          


Leu Arg Gly Leu Asn Ser Lys Gln His Cys Leu Leu Glu Ser Pro Xaa 
        35                  40                  45              


Gly Ser Gly Lys Ser Leu Ala Leu Leu Cys Ser Ala Leu Ala Trp Gln 
    50                  55                  60                  


Gln Ser Leu Ser Gly Lys Pro Ala Asp Glu Gly Val Ser Glu Lys Ala 
65                  70                  75                  80  


Glu Val Gln Leu Ser Cys Cys Cys Ala Cys His Ser Lys Asp Phe Xaa 
                85                  90                  95      


Asn Asn Asp Met Asn Gln Gly Xaa Ser Arg His Phe Asn Tyr Pro Ser 
            100                 105                 110         


Xaa Pro Pro Ser Glu Arg Asn Gly Xaa Ser Ser Xaa Cys Gln Asp Ser 
        115                 120                 125             


Pro Glu Lys Xaa Xaa Leu Ala Ala Lys Leu Ser Ala Lys Lys Gln Ala 
    130                 135                 140                 


Ser Ile Tyr Arg Asp Glu Asn Asp Asp Phe Gln Val Glu Lys Lys Arg 
145                 150                 155                 160 


Ile Arg Pro Leu Glu Xaa Xaa Gln Gln Ile Arg Lys Arg His Cys Phe 
                165                 170                 175     


Gly Xaa Glu Val His Asn Leu Asp Ala Lys Val Asp Ser Gly Lys Xaa 
            180                 185                 190         


Val Lys Leu Asn Ser Pro Leu Glu Lys Ile Asn Ser Phe Ser Pro Gln 
        195                 200                 205             


Lys Pro Pro Gly His Cys Ser Arg Cys Cys Cys Ser Xaa Lys Gln Gly 
    210                 215                 220                 


Asn Ser Gln Glu Ser Ser Asn Xaa Ile Lys Lys Asp His Xaa Gly Lys 
225                 230                 235                 240 


Ser Lys Ile Pro Lys Ile Tyr Phe Gly Xaa Arg Xaa His Lys Gln Ile 
                245                 250                 255     


Ala Gln Ile Xaa Arg Glu Leu Arg Arg Xaa Ala Tyr Ser Gly Val Pro 
            260                 265                 270         


Met Xaa Ile Leu Ser Ser Arg Asp His Xaa Cys Val His Pro Glu Val 
        275                 280                 285             


Val Gly Asn Phe Asn Arg Asn Glu Lys Cys Met Glu Leu Leu Asp Gly 
    290                 295                 300                 


Lys Asn Gly Lys Ser Cys Tyr Phe Tyr His Gly Val His Lys Ile Ser 
305                 310                 315                 320 


Asp Gln His Xaa Leu Gln Xaa Phe Gln Gly Met Cys Lys Ala Trp Asp 
                325                 330                 335     


Ile Glu Glu Leu Val Ser Leu Gly Lys Lys Leu Lys Ala Cys Pro Tyr 
            340                 345                 350         


Tyr Xaa Ala Arg Glu Leu Ile Gln Asp Ala Asp Ile Ile Phe Cys Pro 
        355                 360                 365             


Tyr Asn Tyr Leu Leu Asp Ala Gln Ile Arg Glu Ser Met Asp Leu Asn 
    370                 375                 380                 


Leu Lys Glu Gln Val Val Ile Leu Asp Glu Ala His Asn Ile Glu Asp 
385                 390                 395                 400 


Cys Ala Arg Glu Ser Ala Ser Tyr Ser Val Xaa Glu Val Gln Leu Arg 
                405                 410                 415     


Phe Ala Arg Asp Glu Leu Asp Ser Met Val Asn Asn Asn Ile Arg Lys 
            420                 425                 430         


Lys Asp His Glu Pro Leu Arg Ala Val Cys Cys Ser Leu Ile Asn Trp 
        435                 440                 445             


Leu Glu Ala Asn Ala Glu Tyr Leu Val Glu Arg Asp Tyr Glu Ser Ala 
    450                 455                 460                 


Cys Lys Ile Trp Ser Gly Asn Glu Met Leu Leu Xaa Leu His Lys Met 
465                 470                 475                 480 


Gly Ile Xaa Xaa Ala Xaa Phe Pro Ile Leu Gln Gly His Phe Ser Ala 
                485                 490                 495     


Val Leu Gln Lys Glu Glu Lys Ile Ser Pro Ile Tyr Gly Lys Glu Glu 
            500                 505                 510         


Ala Arg Glu Val Pro Val Ile Ser Ala Ser Xaa Gln Ile Met Leu Lys 
        515                 520                 525             


Gly Leu Phe Met Val Leu Asp Tyr Leu Phe Arg Gln Asn Ser Arg Phe 
    530                 535                 540                 


Ala Asp Asp Tyr Lys Ile Ala Ile Gln Gln Xaa Tyr Ser Trp Xaa Asn 
545                 550                 555                 560 


Gln Ile Asp Ile Ser Asp Lys Asn Gly Leu Leu Val Leu Pro Lys Asn 
                565                 570                 575     


Lys Lys Arg Ser Arg Gln Lys Xaa Ala Val His Val Leu Asn Phe Trp 
            580                 585                 590         


Cys Leu Asn Pro Ala Val Ala Phe Ser Asp Ile Asn Gly Lys Val Gln 
        595                 600                 605             


Xaa Ile Val Leu Xaa Ser Gly Xaa Leu Ser Pro Met Lys Ser Phe Ser 
    610                 615                 620                 


Ser Glu Leu Gly Val Xaa Phe Xaa Ile Gln Leu Glu Ala Asn His Ile 
625                 630                 635                 640 


Ile Lys Asn Ser Gln Val Trp Val Gly Xaa Ile Gly Ser Gly Pro Lys 
                645                 650                 655     


Gly Arg Asn Leu Cys Ala Xaa Phe Gln Asn Xaa Glu Xaa Phe Glu Phe 
            660                 665                 670         


Gln Asp Glu Val Gly Ala Leu Leu Leu Ser Val Cys Gln Xaa Val Ser 
        675                 680                 685             


Gln Gly Ile Leu Cys Phe Leu Pro Ser Tyr Lys Leu Leu Glu Lys Leu 
    690                 695                 700                 


Lys Glu Arg Trp Leu Ser Xaa Gly Leu Trp His Asn Leu Glu Leu Val 
705                 710                 715                 720 


Lys Xaa Val Ile Val Glu Pro Gln Gly Gly Glu Lys Xaa Asn Phe Asp 
                725                 730                 735     


Glu Leu Leu Gln Val Tyr Tyr Asp Ala Ile Lys Tyr Lys Gly Glu Lys 
            740                 745                 750         


Asp Gly Ala Leu Leu Val Ala Val Cys Arg Gly Lys Val Ser Glu Gly 
        755                 760                 765             


Leu Asp Phe Ser Asp Asp Asn Ala Arg Ala Val Ile Xaa Ile Gly Ile 
    770                 775                 780                 


Pro Phe Pro Asn Val Lys Asp Leu Gln Val Glu Leu Lys Arg Gln Tyr 
785                 790                 795                 800 


Asn Asp His His Ser Lys Leu Arg Gly Leu Leu Pro Gly Arg Gln Trp 
                805                 810                 815     


Tyr Glu Ile Gln Ala Tyr Arg Ala Leu Asn Gln Ala Leu Gly Arg Cys 
            820                 825                 830         


Ile Arg His Arg Asn Asp Trp Gly Ala Leu Ile Leu Val Asp Asp Arg 
        835                 840                 845             


Phe Arg Asn Asn Pro Ser Arg Tyr Ile Ser Gly Leu Ser Lys Trp Val 
    850                 855                 860                 


Arg Gln Gln Ile Gln His His Ser Xaa Phe Glu Ser Ala Leu Glu Ser 
865                 870                 875                 880 


Leu Ala Glu Phe Ser Lys Lys His Gln Lys Val Leu Asn Val Ser Ile 
                885                 890                 895     


Lys Asp Arg Xaa Asn Ile Gln Asp Asn Glu Ser Xaa Leu Glu Val Xaa 
            900                 905                 910         


Ser Leu Lys Tyr Ser Xaa Ser Pro Tyr Leu Leu Glu Ala Ala Ser His 
        915                 920                 925             


Leu Ser Pro Glu Asn Phe Val Glu Asp Glu Ala Lys Ile Cys Val Gln 
    930                 935                 940                 


Glu Leu Gln Cys Pro Lys Ile Ile Xaa Lys Asn Ser Pro Leu Pro Ser 
945                 950                 955                 960 


Ser Ile Ile Ser Arg Lys Glu Lys Asn Asp Pro Val Phe Leu Glu Glu 
                965                 970                 975     


Ala Gly Lys Ala Glu Lys Ile Val Ile Ser Arg Ser Xaa Ser Pro Xaa 
            980                 985                 990         


Phe Asn Lys Gln Xaa Lys Arg Val  Ser Trp Ser Ser Phe  Asn Ser Leu 
        995                 1000                 1005             


Gly Gln  Tyr Phe Xaa Gly Lys  Ile Pro Lys Ala Xaa  Pro Glu Leu 
    1010                 1015                 1020             


Gly Ser  Ser Glu Asn Ser Ala  Ser Ser Pro Pro Arg  Phe Lys Xaa 
    1025                 1030                 1035             


Glu Lys  Met Glu Ser Lys Xaa  Val Leu Pro Phe Xaa  Asp Lys Cys 
    1040                 1045                 1050             


Glu Ser  Ser Asn Leu Xaa Val  Asn Xaa Ser Phe Gly  Ser Cys Pro 
    1055                 1060                 1065             


Gln Ser  Glu Xaa Ile Ile Ser  Ser Leu Lys Ile Asp  Ala Xaa Leu 
    1070                 1075                 1080             


Xaa Arg  Lys Asn His Ser Glu  His Pro Leu Cys Ser  Glu Glu Ala 
    1085                 1090                 1095             


Leu Asp  Pro Asp Ile Glu Leu  Ser Leu Val Ser Glu  Glu Asp Lys 
    1100                 1105                 1110             


Gln Ser  Xaa Ser Asn Arg Asp  Phe Glu Xaa Glu Ala  Glu Asp Glu 
    1115                 1120                 1125             


Ser Ile  Tyr Phe Xaa Pro Glu  Leu Tyr Asp Pro Glu  Asp Xaa Asp 
    1130                 1135                 1140             


Glu Glu  Lys Asn Asp Leu Ala  Glu Xaa Asp Arg Gly  Asn Arg Leu 
    1145                 1150                 1155             


Ala Asn  Asn Ser Asp Cys Ile  Leu Ala Lys Asp Leu  Phe Glu Ile 
    1160                 1165                 1170             


Arg Xaa  Ile Lys Glu Val Asp  Ser Ala Arg Glu Val  Lys Ala Glu 
    1175                 1180                 1185             


Asp Cys  Ile Asp Xaa Lys Leu  Asn Gly Ile Leu His  Ile Glu Glu 
    1190                 1195                 1200             


Ser Lys  Ile Asp Asp Ile Asp  Gly Asn Val Lys Xaa  Xaa Trp Ile 
    1205                 1210                 1215             


Asn Glu  Leu Glu Leu Gly Lys  Xaa His Glu Ile Glu  Ile Lys Asn 
    1220                 1225                 1230             


Phe Lys  Pro Ser Pro Ser Lys  Asn Lys Gly Met Phe  Pro Gly Phe 
    1235                 1240                 1245             


Lys 
    


<210> 4438
<211> 180
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<400> 4438
Xaa Asp Glu Val Gly Ala Leu Leu Leu Ser Val Cys Gln Xaa Val Ser 
1               5                   10                  15      


Gln Gly Ile Leu Cys Phe Leu Pro Ser Tyr Lys Leu Leu Glu Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Leu Ser Xaa Gly Leu Trp His Asn Leu Glu Leu Val 
        35                  40                  45              


Lys Xaa Val Ile Val Glu Pro Gln Gly Gly Glu Lys Xaa Asn Phe Asp 
    50                  55                  60                  


Glu Leu Leu Gln Val Tyr Tyr Asp Ala Ile Lys Tyr Lys Gly Glu Lys 
65                  70                  75                  80  


Asp Gly Ala Leu Leu Val Ala Val Cys Arg Gly Lys Val Ser Glu Gly 
                85                  90                  95      


Leu Asp Phe Ser Asp Asp Asn Ala Arg Ala Val Ile Xaa Ile Gly Ile 
            100                 105                 110         


Pro Phe Pro Asn Val Lys Asp Leu Gln Leu Xaa Ser Ala Xaa Ala Glu 
        115                 120                 125             


Gly Xaa Asn Gly Tyr Ala Gln Ser Trp Val Ser Tyr Ser Lys Met Ala 
    130                 135                 140                 


Asp Ala Ala Leu Xaa Xaa Ala Xaa Asp Glu Xaa Val Asp Ile Tyr Pro 
145                 150                 155                 160 


Arg Asn Leu Leu Ser Pro Ser Xaa Ala Leu Val Leu His Ser Xaa Glu 
                165                 170                 175     


Val Glu Cys Tyr 
            180 


<210> 4439
<211> 84
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<400> 4439
Xaa Ile Trp Ser Gly Asn Glu Met Leu Leu Xaa Leu His Lys Met Gly 
1               5                   10                  15      


Ile Xaa Xaa Ala Xaa Phe Pro Ile Leu Gln Gly His Phe Ser Ala Val 
            20                  25                  30          


Leu Gln Lys Glu Glu Lys Ile Ser Pro Ile Tyr Gly Lys Glu Glu Ala 
        35                  40                  45              


Arg Glu Val Pro Val Ile Ser Ala Ser Xaa Gln Ile Met Leu Lys Gly 
    50                  55                  60                  


Leu Phe Met Val Leu Asp Tyr Leu Phe Arg Gln Asn Ser Arg Asp Glu 
65                  70                  75                  80  


Ile Ser Leu Cys 
                


<210> 4440
<211> 75
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<400> 4440
Met Ala Gly Gln Glu Asp Pro Val Gln Arg Glu Ile His Gln Asp Trp 
1               5                   10                  15      


Ala Asn Arg Glu Tyr Ile Glu Ile Ile Xaa Ser Ser Ile Lys Lys Ile 
            20                  25                  30          


Ala Asp Phe Leu Asn Ser Phe Asp Met Ser Cys Arg Ser Arg Leu Ala 
        35                  40                  45              


Xaa Leu Asn Glu Lys Leu Xaa Ala Leu Glu Arg Arg Ile Glu Tyr Ile 
    50                  55                  60                  


Glu Ala Arg Val Xaa Lys Gly Glu Xaa Leu Xaa 
65                  70                  75  


<210> 4441
<211> 126
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<400> 4441
Met Pro Val Gln Pro Pro Ser Lys Asp Xaa Glu Glu Met Glu Ala Glu 
1               5                   10                  15      


Gly Asp Ser Ala Ala Glu Met Asn Gly Glu Glu Glu Glu Ser Glu Glu 
            20                  25                  30          


Glu Arg Ser Gly Ser Gln Xaa Glu Ser Glu Glu Glu Ser Ser Glu Met 
        35                  40                  45              


Asp Asp Glu Asp Tyr Glu Arg Arg Arg Ser Glu Cys Val Ser Glu Met 
    50                  55                  60                  


Leu Asp Leu Glu Lys Gln Phe Ser Glu Leu Lys Glu Lys Leu Phe Arg 
65                  70                  75                  80  


Glu Arg Leu Ser Gln Leu Arg Leu Arg Leu Glu Glu Val Gly Ala Glu 
                85                  90                  95      


Arg Ala Pro Glu Tyr Xaa Glu Pro Leu Gly Gly Leu Gln Arg Ser Leu 
            100                 105                 110         


Lys Ile Arg Ile Gln Gly Ser Xaa Arg Ala Ser Val Trp Met 
        115                 120                 125     


<210> 4442
<211> 244
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<400> 4442
Met Pro Val Gln Pro Pro Ser Lys Asp Xaa Glu Glu Met Glu Ala Glu 
1               5                   10                  15      


Gly Asp Ser Ala Ala Glu Met Asn Gly Glu Glu Glu Glu Ser Glu Glu 
            20                  25                  30          


Glu Arg Ser Gly Ser Gln Xaa Glu Ser Glu Glu Glu Ser Ser Glu Met 
        35                  40                  45              


Asp Asp Glu Asp Tyr Glu Arg Arg Arg Ser Glu Cys Val Ser Glu Met 
    50                  55                  60                  


Leu Asp Leu Glu Lys Gln Phe Ser Glu Leu Lys Glu Lys Leu Phe Arg 
65                  70                  75                  80  


Glu Arg Leu Ser Gln Leu Arg Leu Arg Leu Glu Glu Val Gly Ala Glu 
                85                  90                  95      


Arg Ala Pro Glu Tyr Xaa Glu Pro Leu Gly Gly Leu Gln Arg Ser Leu 
            100                 105                 110         


Lys Ile Arg Ile Gln Val Ala Gly Ile Tyr Lys Gly Phe Cys Leu Asp 
        115                 120                 125             


Val Ile Arg Asn Lys Tyr Glu Cys Glu Leu Gln Gly Ala Lys Gln His 
    130                 135                 140                 


Leu Glu Ser Glu Lys Leu Leu Leu Tyr Asp Xaa Leu Gln Gly Glu Leu 
145                 150                 155                 160 


Gln Glu Arg Ile Gln Arg Leu Glu Glu Asp Arg Gln Ser Leu Asp Leu 
                165                 170                 175     


Ser Ser Glu Trp Trp Asp Asp Lys Leu His Ala Arg Gly Ser Ser Arg 
            180                 185                 190         


Ser Trp Asp Ser Leu Pro Pro Ser Lys Arg Lys Lys Ala Pro Leu Val 
        195                 200                 205             


Ser Gly Pro Tyr Ile Val Tyr Met Leu Gln Glu Ile Asp Ile Leu Glu 
    210                 215                 220                 


Asp Trp Xaa Ala Ile Lys Lys Ala Arg Ala Ala Val Ser Pro Gln Lys 
225                 230                 235                 240 


Arg Lys Ser Asp 
                


<210> 4443
<211> 290
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<400> 4443
Met Pro Val Gln Pro Pro Ser Lys Asp Xaa Glu Glu Met Glu Ala Glu 
1               5                   10                  15      


Gly Asp Ser Ala Ala Glu Met Asn Gly Glu Glu Glu Glu Ser Glu Glu 
            20                  25                  30          


Glu Arg Ser Gly Ser Gln Xaa Glu Ser Glu Glu Glu Ser Ser Glu Met 
        35                  40                  45              


Asp Asp Glu Asp Tyr Glu Arg Arg Arg Ser Glu Cys Val Ser Glu Met 
    50                  55                  60                  


Leu Asp Leu Glu Lys Gln Phe Ser Glu Leu Lys Glu Lys Leu Phe Arg 
65                  70                  75                  80  


Glu Arg Leu Ser Gln Leu Arg Leu Arg Leu Glu Glu Val Gly Ala Glu 
                85                  90                  95      


Arg Ala Pro Glu Tyr Xaa Glu Pro Leu Gly Gly Leu Gln Arg Ser Leu 
            100                 105                 110         


Lys Ile Arg Ile Gln Val Ala Gly Ile Tyr Lys Gly Phe Cys Leu Asp 
        115                 120                 125             


Val Ile Arg Asn Lys Tyr Glu Cys Glu Leu Gln Gly Ala Lys Gln His 
    130                 135                 140                 


Leu Glu Ser Glu Lys Leu Leu Leu Tyr Asp Xaa Leu Gln Gly Glu Leu 
145                 150                 155                 160 


Gln Glu Arg Ile Gln Arg Leu Glu Glu Asp Arg Gln Ser Leu Asp Leu 
                165                 170                 175     


Ser Ser Glu Trp Trp Asp Asp Lys Leu His Ala Arg Gly Ser Ser Arg 
            180                 185                 190         


Ser Trp Asp Ser Leu Pro Pro Ser Lys Arg Lys Lys Ala Pro Leu Val 
        195                 200                 205             


Ser Gly Pro Tyr Ile Val Tyr Met Leu Gln Glu Ile Asp Ile Leu Glu 
    210                 215                 220                 


Asp Trp Xaa Ala Ile Lys Lys Ala Arg Ala Ala Val Ser Pro Gln Lys 
225                 230                 235                 240 


Arg Lys Ser Asp Asp Arg Arg Xaa His Arg Pro Leu Arg Val Cys Pro 
                245                 250                 255     


Ala Arg Leu Leu Trp Cys Cys Trp Ala Leu Pro Leu His Leu Ala Leu 
            260                 265                 270         


Ala Trp Xaa Pro Pro Leu Pro Ser Ser Arg Pro Ala Gln Leu Trp Pro 
        275                 280                 285             


Trp Ser 
    290 


<210> 4444
<211> 246
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<400> 4444
Met Pro Val Gln Pro Pro Ser Lys Asp Xaa Glu Glu Met Glu Ala Glu 
1               5                   10                  15      


Gly Asp Ser Ala Ala Glu Met Asn Gly Glu Glu Glu Glu Ser Glu Glu 
            20                  25                  30          


Glu Arg Ser Gly Ser Gln Xaa Glu Ser Glu Glu Glu Ser Ser Glu Met 
        35                  40                  45              


Asp Asp Glu Asp Tyr Glu Arg Arg Arg Ser Glu Cys Val Ser Glu Met 
    50                  55                  60                  


Leu Asp Leu Glu Lys Gln Phe Ser Glu Leu Lys Glu Lys Leu Phe Arg 
65                  70                  75                  80  


Glu Arg Leu Ser Gln Leu Arg Leu Arg Leu Glu Glu Val Gly Ala Glu 
                85                  90                  95      


Arg Ala Pro Glu Tyr Xaa Glu Pro Leu Gly Gly Leu Gln Arg Ser Leu 
            100                 105                 110         


Lys Ile Arg Ile Gln Val Ala Gly Ile Tyr Lys Gly Phe Cys Leu Asp 
        115                 120                 125             


Val Ile Arg Asn Lys Tyr Glu Cys Glu Leu Gln Gly Ala Lys Gln His 
    130                 135                 140                 


Leu Glu Ser Glu Lys Leu Leu Leu Tyr Asp Xaa Leu Gln Gly Glu Leu 
145                 150                 155                 160 


Gln Glu Arg Ile Gln Arg Leu Glu Glu Asp Arg Gln Ser Leu Asp Leu 
                165                 170                 175     


Ser Ser Glu Trp Trp Asp Asp Lys Leu His Ala Arg Gly Ser Ser Arg 
            180                 185                 190         


Ser Trp Asp Ser Leu Pro Pro Ser Lys Arg Lys Lys Ala Pro Leu Val 
        195                 200                 205             


Ser Gly Pro Tyr Ile Val Tyr Met Leu Gln Glu Ile Asp Ile Leu Glu 
    210                 215                 220                 


Asp Trp Xaa Ala Ile Lys Lys Ala Arg Ala Ala Val Ser Pro Gln Lys 
225                 230                 235                 240 


Arg Lys Ser Asp Gly Pro 
                245     


<210> 4445
<211> 267
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<400> 4445
Xaa Xaa Glu Ser Glu Glu Glu Ser Ser Glu Met Asp Asp Glu Asp Tyr 
1               5                   10                  15      


Glu Arg Arg Arg Ser Glu Cys Val Ser Glu Met Leu Asp Leu Glu Lys 
            20                  25                  30          


Gln Phe Ser Glu Leu Lys Glu Lys Leu Phe Arg Glu Arg Leu Ser Gln 
        35                  40                  45              


Leu Arg Leu Arg Leu Glu Glu Val Gly Ala Glu Arg Ala Pro Glu Tyr 
    50                  55                  60                  


Xaa Glu Pro Leu Gly Gly Leu Gln Arg Ser Leu Lys Ile Arg Ile Gln 
65                  70                  75                  80  


Val Ala Gly Ile Tyr Lys Gly Phe Cys Leu Asp Val Ile Arg Asn Lys 
                85                  90                  95      


Tyr Glu Cys Glu Leu Gln Gly Ala Lys Gln His Leu Glu Ser Glu Lys 
            100                 105                 110         


Leu Leu Leu Tyr Asp Xaa Leu Gln Gly Glu Leu Gln Glu Arg Ile Gln 
        115                 120                 125             


Arg Leu Glu Glu Asp Arg Gln Ser Leu Asp Leu Ser Ser Glu Trp Trp 
    130                 135                 140                 


Asp Asp Lys Leu His Ala Arg Gly Ser Ser Arg Ser Trp Asp Ser Leu 
145                 150                 155                 160 


Pro Pro Ser Lys Arg Lys Lys Ala Pro Leu Val Ser Gly Pro Tyr Ile 
                165                 170                 175     


Val Tyr Met Leu Gln Glu Ile Asp Ile Leu Glu Asp Trp Xaa Ala Ile 
            180                 185                 190         


Lys Lys Asp Leu Asp Pro Ala Val His Ser Gln Gly Asp Pro Gln Ser 
        195                 200                 205             


Ser Trp His Cys Xaa Gln Asp Ser Arg Leu Pro Pro Ala Asp Arg Arg 
    210                 215                 220                 


Xaa His Arg Pro Leu Arg Val Cys Pro Ala Arg Leu Leu Trp Cys Cys 
225                 230                 235                 240 


Trp Ala Leu Pro Leu His Leu Ala Leu Ala Trp Xaa Pro Pro Leu Pro 
                245                 250                 255     


Ser Ser Arg Pro Ala Gln Leu Trp Pro Trp Ser 
            260                 265         


<210> 4446
<211> 100
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<400> 4446
Met Gly Val Asp Phe Asp Val Lys Xaa Phe Cys His Asn Leu Arg Ala 
1               5                   10                  15      


Xaa Lys Pro Pro Tyr Glu Cys Pro Val Glu Xaa Cys Arg Lys Val Tyr 
            20                  25                  30          


Lys Ser Tyr Ser Gly Ile Glu Tyr His Leu Tyr His Tyr Asp His Asp 
        35                  40                  45              


Asn Pro Pro Pro Pro Gln Gln Xaa Pro Leu Arg Lys His Lys Lys Lys 
    50                  55                  60                  


Gly Arg Gln Ser Arg Pro Ala Asn Lys Gln Ser Pro Ser Pro Ser Glu 
65                  70                  75                  80  


Val Ser Gln Ser Pro Gly Arg Glu Val Met Ser Tyr Ala Gln Ala Gln 
                85                  90                  95      


Arg Met Val Glu 
            100 


<210> 4447
<211> 105
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<400> 4447
Met Gly Val Asp Phe Asp Val Lys Xaa Phe Cys His Asn Leu Arg Ala 
1               5                   10                  15      


Xaa Lys Pro Pro Tyr Glu Cys Pro Val Glu Xaa Cys Arg Lys Val Tyr 
            20                  25                  30          


Lys Ser Tyr Ser Gly Ile Glu Tyr His Leu Tyr His Tyr Asp His Asp 
        35                  40                  45              


Asn Pro Pro Pro Pro Gln Gln Xaa Pro Leu Arg Lys His Lys Lys Lys 
    50                  55                  60                  


Gly Arg Gln Ser Arg Pro Ala Asn Lys Gln Ser Pro Ser Pro Ser Glu 
65                  70                  75                  80  


Val Ser Gln Ser Pro Gly Arg Glu Val Met Ser Tyr Ala Gln Ala Gln 
                85                  90                  95      


Arg Met Val Glu Val Asp Leu His Gly 
            100                 105 


<210> 4448
<211> 1119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1058)..(1058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<400> 4448
Met Gly Val Asp Phe Asp Val Lys Xaa Phe Cys His Asn Leu Arg Ala 
1               5                   10                  15      


Xaa Lys Pro Pro Tyr Glu Cys Pro Val Glu Xaa Cys Arg Lys Val Tyr 
            20                  25                  30          


Lys Ser Tyr Ser Gly Ile Glu Tyr His Leu Tyr His Tyr Asp His Asp 
        35                  40                  45              


Asn Pro Pro Pro Pro Gln Gln Xaa Pro Leu Arg Lys His Lys Lys Lys 
    50                  55                  60                  


Gly Arg Gln Ser Arg Pro Ala Asn Lys Gln Ser Pro Ser Pro Ser Glu 
65                  70                  75                  80  


Val Ser Gln Ser Pro Gly Arg Glu Val Met Ser Tyr Ala Gln Ala Gln 
                85                  90                  95      


Arg Met Val Glu Val Asp Leu His Gly Arg Val His Arg Ile Ser Ile 
            100                 105                 110         


Phe Asp Asn Leu Asp Val Val Ser Glu Asp Glu Glu Ala Pro Glu Glu 
        115                 120                 125             


Ala Pro Glu Asn Gly Ser Asn Lys Glu Asn Xaa Glu Xaa Pro Ala Ala 
    130                 135                 140                 


Xaa Pro Lys Ser Gly Lys His Lys Asn Lys Glu Lys Arg Lys Asp Ser 
145                 150                 155                 160 


Asn His His His His His Asn Val Ser Ala Ser Xaa Xaa Pro Lys Leu 
                165                 170                 175     


Pro Glu Val Val Tyr Arg Glu Leu Glu Gln Asp Xaa Pro Asp Ala Pro 
            180                 185                 190         


Pro Arg Pro Xaa Ser Tyr Tyr Arg Tyr Ile Glu Lys Ser Ala Glu Glu 
        195                 200                 205             


Leu Asp Glu Glu Val Glu Tyr Asp Met Asp Glu Glu Asp Tyr Ile Trp 
    210                 215                 220                 


Leu Asp Ile Met Asn Glu Arg Arg Lys Xaa Glu Gly Val Ser Pro Ile 
225                 230                 235                 240 


Pro Gln Glu Ile Phe Glu Tyr Leu Met Asp Arg Leu Glu Lys Glu Ser 
                245                 250                 255     


Tyr Phe Glu Ser His Asn Lys Gly Asp Pro Asn Ala Leu Val Asp Glu 
            260                 265                 270         


Asp Ala Val Cys Cys Ile Cys Asn Asp Gly Glu Cys Gln Asn Ser Asn 
        275                 280                 285             


Val Ile Leu Phe Cys Asp Met Cys Asn Leu Ala Val His Gln Glu Cys 
    290                 295                 300                 


Tyr Gly Val Pro Tyr Ile Pro Glu Gly Gln Trp Leu Cys Arg Arg Cys 
305                 310                 315                 320 


Leu Gln Ser Pro Ser Arg Ala Val Asp Cys Ala Leu Cys Pro Asn Lys 
                325                 330                 335     


Gly Gly Ala Phe Lys Gln Xaa Asp Asp Gly Arg Trp Ala His Val Val 
            340                 345                 350         


Cys Ala Leu Trp Ile Pro Glu Val Cys Phe Ala Asn Xaa Val Phe Leu 
        355                 360                 365             


Glu Pro Ile Asp Ser Ile Glu His Ile Pro Pro Ala Arg Trp Lys Leu 
    370                 375                 380                 


Xaa Cys Tyr Ile Cys Lys Gln Arg Gly Ser Gly Ala Cys Ile Gln Cys 
385                 390                 395                 400 


His Lys Ala Asn Cys Tyr Xaa Ala Phe His Val Xaa Cys Ala Gln Gln 
                405                 410                 415     


Ala Gly Leu Tyr Met Lys Met Glu Pro Val Arg Glu Xaa Gly Ala Asn 
            420                 425                 430         


Gly Xaa Ser Phe Ser Val Arg Lys Xaa Ala Tyr Cys Asp Ile His Xaa 
        435                 440                 445             


Pro Pro Gly Ser Ala Arg Arg Leu Pro Ala Leu Ser His Ser Glu Gly 
    450                 455                 460                 


Glu Glu Asp Glu Asp Glu Glu Glu Asp Glu Gly Lys Gly Trp Ser Ser 
465                 470                 475                 480 


Glu Lys Val Lys Lys Ala Lys Ala Lys Ser Arg Ile Lys Met Lys Lys 
                485                 490                 495     


Ala Arg Lys Ile Leu Ala Glu Lys Arg Ala Ala Ala Pro Val Val Ser 
            500                 505                 510         


Val Pro Cys Ile Pro Pro His Arg Leu Ser Lys Ile Xaa Asn Arg Leu 
        515                 520                 525             


Xaa Ile Gln Arg Lys Ser Gln Phe Met Gln Arg Leu His Ser Tyr Trp 
    530                 535                 540                 


Xaa Leu Lys Arg Gln Ser Arg Asn Gly Val Pro Leu Leu Arg Arg Leu 
545                 550                 555                 560 


Gln Xaa His Leu Gln Ser Gln Arg Asn Cys Asp Gln Val Gly Arg Asp 
                565                 570                 575     


Ser Glu Asp Lys Asn Trp Ala Leu Lys Glu Gln Leu Lys Ser Trp Gln 
            580                 585                 590         


Arg Leu Arg His Asp Leu Glu Arg Ala Arg Leu Leu Val Glu Leu Ile 
        595                 600                 605             


Arg Lys Arg Glu Lys Leu Lys Arg Glu Xaa Ile Lys Val Gln Gln Ile 
    610                 615                 620                 


Ala Met Glu Met Gln Leu Xaa Pro Phe Leu Ile Leu Leu Arg Lys Xaa 
625                 630                 635                 640 


Leu Glu Gln Leu Gln Glu Lys Asp Xaa Gly Asn Ile Phe Ser Glu Pro 
                645                 650                 655     


Val Pro Leu Ser Glu Val Pro Asp Tyr Leu Asp His Ile Lys Lys Pro 
            660                 665                 670         


Met Asp Phe Phe Xaa Met Lys Gln Asn Leu Glu Ala Tyr Arg Tyr Leu 
        675                 680                 685             


Asn Phe Asp Asp Phe Glu Glu Asp Phe Asn Leu Ile Val Ser Asn Cys 
    690                 695                 700                 


Leu Lys Tyr Asn Ala Lys Asp Xaa Ile Phe Tyr Arg Ala Ala Val Arg 
705                 710                 715                 720 


Leu Arg Glu Gln Gly Gly Ala Val Leu Arg Gln Ala Arg Arg Gln Ala 
                725                 730                 735     


Glu Lys Met Gly Ile Asp Phe Glu Xaa Gly Met His Ile Pro His Ser 
            740                 745                 750         


Leu Ala Gly Asp Glu Ala Xaa His His Xaa Glu Asp Ala Ala Glu Glu 
        755                 760                 765             


Glu Arg Leu Val Leu Leu Glu Asn Gln Lys His Leu Pro Val Glu Glu 
    770                 775                 780                 


Gln Leu Lys Leu Leu Leu Glu Arg Leu Asp Glu Val Asn Ala Ser Lys 
785                 790                 795                 800 


Gln Ser Val Gly Arg Ser Arg Arg Ala Lys Met Ile Lys Lys Glu Met 
                805                 810                 815     


Xaa Ala Leu Arg Arg Lys Leu Ala His Gln Arg Glu Xaa Gly Arg Asp 
            820                 825                 830         


Gly Pro Glu Arg His Gly Pro Ser Ser Arg Gly Ser Leu Xaa Pro His 
        835                 840                 845             


Pro Ala Ala Cys Asp Lys Asp Gly Gln Xaa Asp Ser Ala Ala Glu Glu 
    850                 855                 860                 


Ser Ser Ser Gln Glu Xaa Ser Lys Asp Leu Pro Ala Asn Gly Phe Ser 
865                 870                 875                 880 


Gly Gly Asn Gln Pro Val Lys Lys Ser Phe Leu Val Tyr Arg Asn Asp 
                885                 890                 895     


Cys Ser Leu Pro Arg Ser Ser Ser Asp Ser Glu Ser Ser Ser Ser Ser 
            900                 905                 910         


Ser Ser Ser Ala Ala Ser Asp Arg Xaa Ser Xaa Xaa Pro Ser Lys Gln 
        915                 920                 925             


Gly Arg Gly Lys Pro Ser Phe Ser Arg Gly Xaa Phe Pro Glu Asp Ser 
    930                 935                 940                 


Ser Glu Asp Xaa Ser Gly Xaa Glu Asn Glu Ala Tyr Ser Val Gly Xaa 
945                 950                 955                 960 


Gly Arg Gly Val Gly His Ser Met Val Arg Lys Ser Leu Gly Arg Gly 
                965                 970                 975     


Ala Gly Trp Leu Ser Glu Asp Glu Asp Ser Pro Leu Asp Ala Leu Asp 
            980                 985                 990         


Leu Val Trp Ala Lys Cys Arg Gly  Tyr Pro Ser Tyr Pro  Ala Leu Ile 
        995                 1000                 1005             


Ile Asp  Pro Lys Met Pro Arg  Glu Gly Met Phe His  His Gly Val 
    1010                 1015                 1020             


Pro Ile  Pro Val Pro Pro Leu  Glu Val Leu Lys Leu  Gly Glu Gln 
    1025                 1030                 1035             


Met Xaa  Gln Glu Ala Arg Glu  His Leu Tyr Leu Val  Leu Phe Phe 
    1040                 1045                 1050             


Asp Asn  Lys Arg Xaa Trp Gln  Trp Leu Pro Arg Xaa  Lys Leu Val 
    1055                 1060                 1065             


Pro Leu  Gly Val Asn Gln Asp  Leu Asp Lys Glu Lys  Met Leu Glu 
    1070                 1075                 1080             


Gly Arg  Lys Ser Asn Ile Arg  Lys Ser Val Gln Ile  Ala Tyr His 
    1085                 1090                 1095             


Arg Ala  Leu Gln His Arg Ser  Lys Val Gln Gly Glu  Gln Ser Ser 
    1100                 1105                 1110             


Glu Xaa  Ser Asp Ser Asp 
    1115                 


<210> 4449
<211> 1213
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1017)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1152)..(1152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<400> 4449
Met Gly Val Asp Phe Asp Val Lys Xaa Phe Cys His Asn Leu Arg Ala 
1               5                   10                  15      


Xaa Lys Pro Pro Tyr Glu Cys Pro Val Glu Xaa Cys Arg Lys Val Tyr 
            20                  25                  30          


Lys Ser Tyr Ser Gly Ile Glu Tyr His Leu Tyr His Tyr Asp His Asp 
        35                  40                  45              


Asn Pro Pro Pro Pro Gln Gln Xaa Pro Leu Arg Lys His Lys Lys Lys 
    50                  55                  60                  


Gly Arg Gln Ser Arg Pro Ala Asn Lys Gln Ser Pro Ser Pro Ser Glu 
65                  70                  75                  80  


Val Ser Gln Ser Pro Gly Arg Glu Val Met Ser Tyr Ala Gln Ala Gln 
                85                  90                  95      


Arg Met Val Glu Val Asp Leu His Gly Arg Val His Arg Ile Ser Ile 
            100                 105                 110         


Phe Asp Asn Leu Asp Val Val Ser Glu Asp Glu Glu Ala Pro Glu Glu 
        115                 120                 125             


Ala Pro Glu Asn Gly Ser Asn Lys Glu Asn Xaa Glu Xaa Pro Ala Ala 
    130                 135                 140                 


Xaa Pro Lys Ser Gly Lys His Lys Asn Lys Glu Lys Arg Lys Asp Ser 
145                 150                 155                 160 


Asn His His His His His Asn Val Ser Ala Ser Xaa Xaa Pro Lys Leu 
                165                 170                 175     


Pro Glu Val Val Tyr Arg Glu Leu Glu Gln Asp Xaa Pro Asp Ala Pro 
            180                 185                 190         


Pro Arg Pro Xaa Ser Tyr Tyr Arg Tyr Ile Glu Lys Ser Ala Glu Glu 
        195                 200                 205             


Leu Asp Glu Glu Val Glu Tyr Asp Met Asp Glu Glu Asp Tyr Ile Trp 
    210                 215                 220                 


Leu Asp Ile Met Asn Glu Arg Arg Lys Xaa Glu Gly Val Ser Pro Ile 
225                 230                 235                 240 


Pro Gln Glu Ile Phe Glu Tyr Leu Met Asp Arg Leu Glu Lys Glu Ser 
                245                 250                 255     


Tyr Phe Glu Ser His Asn Lys Gly Asp Pro Asn Ala Leu Val Asp Glu 
            260                 265                 270         


Asp Ala Val Cys Cys Ile Cys Asn Asp Gly Glu Cys Gln Asn Ser Asn 
        275                 280                 285             


Val Ile Leu Phe Cys Asp Met Cys Asn Leu Ala Val His Gln Glu Cys 
    290                 295                 300                 


Tyr Gly Val Pro Tyr Ile Pro Glu Gly Gln Trp Leu Cys Arg Arg Cys 
305                 310                 315                 320 


Leu Gln Ser Pro Ser Arg Ala Val Asp Cys Ala Leu Cys Pro Asn Lys 
                325                 330                 335     


Gly Gly Ala Phe Lys Gln Xaa Asp Asp Gly Arg Trp Ala His Val Val 
            340                 345                 350         


Cys Ala Leu Trp Ile Pro Glu Val Cys Phe Ala Asn Xaa Val Phe Leu 
        355                 360                 365             


Glu Pro Ile Asp Ser Ile Glu His Ile Pro Pro Ala Arg Trp Lys Leu 
    370                 375                 380                 


Xaa Cys Tyr Ile Cys Lys Gln Arg Gly Ser Gly Ala Cys Ile Gln Cys 
385                 390                 395                 400 


His Lys Ala Asn Cys Tyr Xaa Ala Phe His Val Xaa Cys Ala Gln Gln 
                405                 410                 415     


Ala Gly Leu Tyr Met Lys Met Glu Pro Val Arg Glu Xaa Gly Ala Asn 
            420                 425                 430         


Gly Xaa Ser Phe Ser Val Arg Lys Xaa Ala Tyr Cys Asp Ile His Xaa 
        435                 440                 445             


Pro Pro Gly Ser Ala Arg Arg Leu Pro Ala Leu Ser His Ser Glu Gly 
    450                 455                 460                 


Glu Glu Asp Glu Asp Glu Glu Glu Asp Glu Gly Lys Gly Trp Ser Ser 
465                 470                 475                 480 


Glu Lys Val Lys Lys Ala Lys Ala Lys Ser Arg Ile Lys Met Lys Lys 
                485                 490                 495     


Ala Arg Lys Ile Leu Ala Glu Lys Arg Ala Ala Ala Pro Val Val Ser 
            500                 505                 510         


Val Pro Cys Ile Pro Pro His Arg Leu Ser Lys Ile Xaa Asn Arg Leu 
        515                 520                 525             


Xaa Ile Gln Arg Lys Ser Gln Phe Met Gln Arg Leu His Ser Tyr Trp 
    530                 535                 540                 


Xaa Leu Lys Arg Gln Ser Arg Asn Gly Val Pro Leu Leu Arg Arg Leu 
545                 550                 555                 560 


Gln Xaa His Leu Gln Ser Gln Arg Asn Cys Asp Gln Val Gly Arg Asp 
                565                 570                 575     


Ser Glu Asp Lys Asn Trp Ala Leu Lys Glu Gln Leu Lys Ser Trp Gln 
            580                 585                 590         


Arg Leu Arg His Asp Leu Glu Arg Ala Arg Leu Leu Val Glu Leu Ile 
        595                 600                 605             


Arg Lys Arg Glu Lys Leu Lys Arg Glu Xaa Ile Lys Val Gln Gln Ile 
    610                 615                 620                 


Ala Met Glu Met Gln Leu Xaa Pro Phe Leu Ile Leu Leu Arg Lys Xaa 
625                 630                 635                 640 


Leu Glu Gln Leu Gln Glu Lys Asp Xaa Gly Asn Ile Phe Ser Glu Pro 
                645                 650                 655     


Val Pro Leu Ser Glu Val Pro Asp Tyr Leu Asp His Ile Lys Lys Pro 
            660                 665                 670         


Met Asp Phe Phe Xaa Met Lys Gln Asn Leu Glu Ala Tyr Arg Tyr Leu 
        675                 680                 685             


Asn Phe Asp Asp Phe Glu Glu Asp Phe Asn Leu Ile Val Ser Asn Cys 
    690                 695                 700                 


Leu Lys Tyr Asn Ala Lys Asp Xaa Ile Phe Tyr Arg Ala Ala Val Arg 
705                 710                 715                 720 


Leu Arg Glu Gln Gly Gly Ala Val Leu Arg Gln Ala Arg Arg Gln Ala 
                725                 730                 735     


Glu Lys Met Gly Ile Asp Phe Glu Xaa Gly Met His Ile Pro His Ser 
            740                 745                 750         


Leu Ala Gly Asp Glu Ala Xaa His His Xaa Glu Asp Ala Glu Glu Glu 
        755                 760                 765             


Arg Leu Val Leu Leu Glu Asn Gln Lys His Leu Pro Val Glu Glu Gln 
    770                 775                 780                 


Leu Lys Leu Leu Leu Glu Arg Leu Asp Glu Val Asn Ala Ser Lys Gln 
785                 790                 795                 800 


Ser Val Gly Arg Ser Arg Arg Ala Lys Met Ile Lys Lys Glu Met Xaa 
                805                 810                 815     


Ala Leu Arg Arg Lys Leu Ala His Gln Arg Glu Xaa Gly Arg Asp Gly 
            820                 825                 830         


Pro Glu Arg His Gly Pro Ser Ser Arg Gly Ser Leu Xaa Pro His Pro 
        835                 840                 845             


Ala Ala Cys Asp Lys Asp Gly Gln Xaa Asp Ser Ala Ala Glu Glu Ser 
    850                 855                 860                 


Ser Ser Gln Glu Xaa Ser Lys Gly Leu Gly Pro Asn Met Ser Ser Xaa 
865                 870                 875                 880 


Pro Ala His Glu Val Gly Arg Arg Xaa Ser Val Leu Phe Ser Lys Lys 
                885                 890                 895     


Asn Pro Lys Xaa Ala Gly Pro Pro Lys Arg Pro Gly Arg Pro Pro Lys 
            900                 905                 910         


Asn Arg Glu Ser Gln Met Xaa Pro Ser His Gly Gly Ser Pro Val Gly 
        915                 920                 925             


Pro Pro Gln Leu Pro Ile Met Ser Ser Leu Arg Gln Arg Lys Arg Gly 
    930                 935                 940                 


Arg Ser Pro Arg Pro Ser Ser Ser Ser Asp Ser Asp Ser Asp Lys Ser 
945                 950                 955                 960 


Xaa Glu Asp Pro Pro Met Asp Leu Pro Ala Asn Gly Phe Ser Gly Gly 
                965                 970                 975     


Asn Gln Pro Val Lys Lys Ser Phe Leu Val Tyr Arg Asn Asp Cys Ser 
            980                 985                 990         


Leu Pro Arg Ser Ser Ser Asp Ser  Glu Ser Ser Ser Ser  Ser Ser Ser 
        995                 1000                 1005             


Ser Ala  Ala Ser Asp Arg Xaa  Ser Xaa Xaa Pro Ser  Lys Gln Gly 
    1010                 1015                 1020             


Arg Gly  Lys Pro Ser Phe Ser  Arg Gly Xaa Phe Pro  Glu Asp Ser 
    1025                 1030                 1035             


Ser Glu  Asp Xaa Ser Gly Xaa  Glu Asn Glu Ala Tyr  Ser Val Gly 
    1040                 1045                 1050             


Xaa Gly  Arg Gly Val Gly His  Ser Met Val Arg Lys  Ser Leu Gly 
    1055                 1060                 1065             


Arg Gly  Ala Gly Trp Leu Ser  Glu Asp Glu Asp Ser  Pro Leu Asp 
    1070                 1075                 1080             


Ala Leu  Asp Leu Val Trp Ala  Lys Cys Arg Gly Tyr  Pro Ser Tyr 
    1085                 1090                 1095             


Pro Ala  Leu Ile Ile Asp Pro  Lys Met Pro Arg Glu  Gly Met Phe 
    1100                 1105                 1110             


His His  Gly Val Pro Ile Pro  Val Pro Pro Leu Glu  Val Leu Lys 
    1115                 1120                 1125             


Leu Gly  Glu Gln Met Xaa Gln  Glu Ala Arg Glu His  Leu Tyr Leu 
    1130                 1135                 1140             


Val Leu  Phe Phe Asp Asn Lys  Arg Xaa Trp Gln Trp  Leu Pro Arg 
    1145                 1150                 1155             


Xaa Lys  Leu Val Pro Leu Gly  Val Asn Gln Asp Leu  Asp Lys Glu 
    1160                 1165                 1170             


Lys Met  Leu Glu Gly Arg Lys  Ser Asn Ile Arg Lys  Ser Val Gln 
    1175                 1180                 1185             


Ile Ala  Tyr His Arg Ala Leu  Gln His Arg Ser Lys  Val Gln Gly 
    1190                 1195                 1200             


Glu Gln  Ser Ser Glu Xaa Ser  Asp Ser Asp 
    1205                 1210             


<210> 4450
<211> 1214
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<400> 4450
Met Gly Val Asp Phe Asp Val Lys Xaa Phe Cys His Asn Leu Arg Ala 
1               5                   10                  15      


Xaa Lys Pro Pro Tyr Glu Cys Pro Val Glu Xaa Cys Arg Lys Val Tyr 
            20                  25                  30          


Lys Ser Tyr Ser Gly Ile Glu Tyr His Leu Tyr His Tyr Asp His Asp 
        35                  40                  45              


Asn Pro Pro Pro Pro Gln Gln Xaa Pro Leu Arg Lys His Lys Lys Lys 
    50                  55                  60                  


Gly Arg Gln Ser Arg Pro Ala Asn Lys Gln Ser Pro Ser Pro Ser Glu 
65                  70                  75                  80  


Val Ser Gln Ser Pro Gly Arg Glu Val Met Ser Tyr Ala Gln Ala Gln 
                85                  90                  95      


Arg Met Val Glu Val Asp Leu His Gly Arg Val His Arg Ile Ser Ile 
            100                 105                 110         


Phe Asp Asn Leu Asp Val Val Ser Glu Asp Glu Glu Ala Pro Glu Glu 
        115                 120                 125             


Ala Pro Glu Asn Gly Ser Asn Lys Glu Asn Xaa Glu Xaa Pro Ala Ala 
    130                 135                 140                 


Xaa Pro Lys Ser Gly Lys His Lys Asn Lys Glu Lys Arg Lys Asp Ser 
145                 150                 155                 160 


Asn His His His His His Asn Val Ser Ala Ser Xaa Xaa Pro Lys Leu 
                165                 170                 175     


Pro Glu Val Val Tyr Arg Glu Leu Glu Gln Asp Xaa Pro Asp Ala Pro 
            180                 185                 190         


Pro Arg Pro Xaa Ser Tyr Tyr Arg Tyr Ile Glu Lys Ser Ala Glu Glu 
        195                 200                 205             


Leu Asp Glu Glu Val Glu Tyr Asp Met Asp Glu Glu Asp Tyr Ile Trp 
    210                 215                 220                 


Leu Asp Ile Met Asn Glu Arg Arg Lys Xaa Glu Gly Val Ser Pro Ile 
225                 230                 235                 240 


Pro Gln Glu Ile Phe Glu Tyr Leu Met Asp Arg Leu Glu Lys Glu Ser 
                245                 250                 255     


Tyr Phe Glu Ser His Asn Lys Gly Asp Pro Asn Ala Leu Val Asp Glu 
            260                 265                 270         


Asp Ala Val Cys Cys Ile Cys Asn Asp Gly Glu Cys Gln Asn Ser Asn 
        275                 280                 285             


Val Ile Leu Phe Cys Asp Met Cys Asn Leu Ala Val His Gln Glu Cys 
    290                 295                 300                 


Tyr Gly Val Pro Tyr Ile Pro Glu Gly Gln Trp Leu Cys Arg Arg Cys 
305                 310                 315                 320 


Leu Gln Ser Pro Ser Arg Ala Val Asp Cys Ala Leu Cys Pro Asn Lys 
                325                 330                 335     


Gly Gly Ala Phe Lys Gln Xaa Asp Asp Gly Arg Trp Ala His Val Val 
            340                 345                 350         


Cys Ala Leu Trp Ile Pro Glu Val Cys Phe Ala Asn Xaa Val Phe Leu 
        355                 360                 365             


Glu Pro Ile Asp Ser Ile Glu His Ile Pro Pro Ala Arg Trp Lys Leu 
    370                 375                 380                 


Xaa Cys Tyr Ile Cys Lys Gln Arg Gly Ser Gly Ala Cys Ile Gln Cys 
385                 390                 395                 400 


His Lys Ala Asn Cys Tyr Xaa Ala Phe His Val Xaa Cys Ala Gln Gln 
                405                 410                 415     


Ala Gly Leu Tyr Met Lys Met Glu Pro Val Arg Glu Xaa Gly Ala Asn 
            420                 425                 430         


Gly Xaa Ser Phe Ser Val Arg Lys Xaa Ala Tyr Cys Asp Ile His Xaa 
        435                 440                 445             


Pro Pro Gly Ser Ala Arg Arg Leu Pro Ala Leu Ser His Ser Glu Gly 
    450                 455                 460                 


Glu Glu Asp Glu Asp Glu Glu Glu Asp Glu Gly Lys Gly Trp Ser Ser 
465                 470                 475                 480 


Glu Lys Val Lys Lys Ala Lys Ala Lys Ser Arg Ile Lys Met Lys Lys 
                485                 490                 495     


Ala Arg Lys Ile Leu Ala Glu Lys Arg Ala Ala Ala Pro Val Val Ser 
            500                 505                 510         


Val Pro Cys Ile Pro Pro His Arg Leu Ser Lys Ile Xaa Asn Arg Leu 
        515                 520                 525             


Xaa Ile Gln Arg Lys Ser Gln Phe Met Gln Arg Leu His Ser Tyr Trp 
    530                 535                 540                 


Xaa Leu Lys Arg Gln Ser Arg Asn Gly Val Pro Leu Leu Arg Arg Leu 
545                 550                 555                 560 


Gln Xaa His Leu Gln Ser Gln Arg Asn Cys Asp Gln Val Gly Arg Asp 
                565                 570                 575     


Ser Glu Asp Lys Asn Trp Ala Leu Lys Glu Gln Leu Lys Ser Trp Gln 
            580                 585                 590         


Arg Leu Arg His Asp Leu Glu Arg Ala Arg Leu Leu Val Glu Leu Ile 
        595                 600                 605             


Arg Lys Arg Glu Lys Leu Lys Arg Glu Xaa Ile Lys Val Gln Gln Ile 
    610                 615                 620                 


Ala Met Glu Met Gln Leu Xaa Pro Phe Leu Ile Leu Leu Arg Lys Xaa 
625                 630                 635                 640 


Leu Glu Gln Leu Gln Glu Lys Asp Xaa Gly Asn Ile Phe Ser Glu Pro 
                645                 650                 655     


Val Pro Leu Ser Glu Val Pro Asp Tyr Leu Asp His Ile Lys Lys Pro 
            660                 665                 670         


Met Asp Phe Phe Xaa Met Lys Gln Asn Leu Glu Ala Tyr Arg Tyr Leu 
        675                 680                 685             


Asn Phe Asp Asp Phe Glu Glu Asp Phe Asn Leu Ile Val Ser Asn Cys 
    690                 695                 700                 


Leu Lys Tyr Asn Ala Lys Asp Xaa Ile Phe Tyr Arg Ala Ala Val Arg 
705                 710                 715                 720 


Leu Arg Glu Gln Gly Gly Ala Val Leu Arg Gln Ala Arg Arg Gln Ala 
                725                 730                 735     


Glu Lys Met Gly Ile Asp Phe Glu Xaa Gly Met His Ile Pro His Ser 
            740                 745                 750         


Leu Ala Gly Asp Glu Ala Xaa His His Xaa Glu Asp Ala Ala Glu Glu 
        755                 760                 765             


Glu Arg Leu Val Leu Leu Glu Asn Gln Lys His Leu Pro Val Glu Glu 
    770                 775                 780                 


Gln Leu Lys Leu Leu Leu Glu Arg Leu Asp Glu Val Asn Ala Ser Lys 
785                 790                 795                 800 


Gln Ser Val Gly Arg Ser Arg Arg Ala Lys Met Ile Lys Lys Glu Met 
                805                 810                 815     


Xaa Ala Leu Arg Arg Lys Leu Ala His Gln Arg Glu Xaa Gly Arg Asp 
            820                 825                 830         


Gly Pro Glu Arg His Gly Pro Ser Ser Arg Gly Ser Leu Xaa Pro His 
        835                 840                 845             


Pro Ala Ala Cys Asp Lys Asp Gly Gln Xaa Asp Ser Ala Ala Glu Glu 
    850                 855                 860                 


Ser Ser Ser Gln Glu Xaa Ser Lys Gly Leu Gly Pro Asn Met Ser Ser 
865                 870                 875                 880 


Xaa Pro Ala His Glu Val Gly Arg Arg Xaa Ser Val Leu Phe Ser Lys 
                885                 890                 895     


Lys Asn Pro Lys Xaa Ala Gly Pro Pro Lys Arg Pro Gly Arg Pro Pro 
            900                 905                 910         


Lys Asn Arg Glu Ser Gln Met Xaa Pro Ser His Gly Gly Ser Pro Val 
        915                 920                 925             


Gly Pro Pro Gln Leu Pro Ile Met Ser Ser Leu Arg Gln Arg Lys Arg 
    930                 935                 940                 


Gly Arg Ser Pro Arg Pro Ser Ser Ser Ser Asp Ser Asp Ser Asp Lys 
945                 950                 955                 960 


Ser Xaa Glu Asp Pro Pro Met Asp Leu Pro Ala Asn Gly Phe Ser Gly 
                965                 970                 975     


Gly Asn Gln Pro Val Lys Lys Ser Phe Leu Val Tyr Arg Asn Asp Cys 
            980                 985                 990         


Ser Leu Pro Arg Ser Ser Ser Asp  Ser Glu Ser Ser Ser  Ser Ser Ser 
        995                 1000                 1005             


Ser Ser  Ala Ala Ser Asp Arg  Xaa Ser Xaa Xaa Pro  Ser Lys Gln 
    1010                 1015                 1020             


Gly Arg  Gly Lys Pro Ser Phe  Ser Arg Gly Xaa Phe  Pro Glu Asp 
    1025                 1030                 1035             


Ser Ser  Glu Asp Xaa Ser Gly  Xaa Glu Asn Glu Ala  Tyr Ser Val 
    1040                 1045                 1050             


Gly Xaa  Gly Arg Gly Val Gly  His Ser Met Val Arg  Lys Ser Leu 
    1055                 1060                 1065             


Gly Arg  Gly Ala Gly Trp Leu  Ser Glu Asp Glu Asp  Ser Pro Leu 
    1070                 1075                 1080             


Asp Ala  Leu Asp Leu Val Trp  Ala Lys Cys Arg Gly  Tyr Pro Ser 
    1085                 1090                 1095             


Tyr Pro  Ala Leu Ile Ile Asp  Pro Lys Met Pro Arg  Glu Gly Met 
    1100                 1105                 1110             


Phe His  His Gly Val Pro Ile  Pro Val Pro Pro Leu  Glu Val Leu 
    1115                 1120                 1125             


Lys Leu  Gly Glu Gln Met Xaa  Gln Glu Ala Arg Glu  His Leu Tyr 
    1130                 1135                 1140             


Leu Val  Leu Phe Phe Asp Asn  Lys Arg Xaa Trp Gln  Trp Leu Pro 
    1145                 1150                 1155             


Arg Xaa  Lys Leu Val Pro Leu  Gly Val Asn Gln Asp  Leu Asp Lys 
    1160                 1165                 1170             


Glu Lys  Met Leu Glu Gly Arg  Lys Ser Asn Ile Arg  Lys Ser Val 
    1175                 1180                 1185             


Gln Ile  Ala Tyr His Arg Ala  Leu Gln His Arg Ser  Lys Val Gln 
    1190                 1195                 1200             


Gly Glu  Gln Ser Ser Glu Xaa  Ser Asp Ser Asp 
    1205                 1210                 


<210> 4451
<211> 1220
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Selenocysteine

<400> 4451
Met Gly Val Asp Phe Asp Val Lys Xaa Phe Cys His Asn Leu Arg Ala 
1               5                   10                  15      


Xaa Lys Pro Pro Tyr Glu Cys Pro Val Glu Xaa Cys Arg Lys Val Tyr 
            20                  25                  30          


Lys Ser Tyr Ser Gly Ile Glu Tyr His Leu Tyr His Tyr Asp His Asp 
        35                  40                  45              


Asn Pro Pro Pro Pro Gln Gln Xaa Pro Leu Arg Lys His Lys Lys Lys 
    50                  55                  60                  


Gly Arg Gln Ser Arg Pro Ala Asn Lys Gln Ser Pro Ser Pro Ser Glu 
65                  70                  75                  80  


Val Ser Gln Ser Pro Gly Arg Glu Val Met Ser Tyr Ala Gln Ala Gln 
                85                  90                  95      


Arg Met Val Glu Val Asp Leu His Gly Arg Val His Arg Ile Ser Ile 
            100                 105                 110         


Phe Asp Asn Leu Asp Val Val Ser Glu Asp Glu Glu Ala Pro Glu Glu 
        115                 120                 125             


Ala Pro Glu Asn Gly Ser Asn Lys Glu Asn Xaa Glu Xaa Pro Ala Ala 
    130                 135                 140                 


Xaa Pro Lys Ser Gly Lys His Lys Asn Lys Glu Lys Arg Lys Asp Ser 
145                 150                 155                 160 


Asn His His His His His Asn Val Ser Ala Ser Xaa Xaa Pro Lys Leu 
                165                 170                 175     


Pro Glu Val Val Tyr Arg Glu Leu Glu Gln Asp Xaa Pro Asp Ala Pro 
            180                 185                 190         


Pro Arg Pro Xaa Ser Tyr Tyr Arg Tyr Ile Glu Lys Ser Ala Glu Glu 
        195                 200                 205             


Leu Asp Glu Glu Val Glu Tyr Asp Met Asp Glu Glu Asp Tyr Ile Trp 
    210                 215                 220                 


Leu Asp Ile Met Asn Glu Arg Arg Lys Xaa Glu Gly Val Ser Pro Ile 
225                 230                 235                 240 


Pro Gln Glu Ile Phe Glu Tyr Leu Met Asp Arg Leu Glu Lys Glu Ser 
                245                 250                 255     


Tyr Phe Glu Ser His Asn Lys Gly Asp Pro Asn Ala Leu Val Asp Glu 
            260                 265                 270         


Asp Ala Val Cys Cys Ile Cys Asn Asp Gly Glu Cys Gln Asn Ser Asn 
        275                 280                 285             


Val Ile Leu Phe Cys Asp Met Cys Asn Leu Ala Val His Gln Glu Cys 
    290                 295                 300                 


Tyr Gly Val Pro Tyr Ile Pro Glu Gly Gln Trp Leu Cys Arg Arg Cys 
305                 310                 315                 320 


Leu Gln Ser Pro Ser Arg Ala Val Asp Cys Ala Leu Cys Pro Asn Lys 
                325                 330                 335     


Gly Gly Ala Phe Lys Gln Xaa Asp Asp Gly Arg Trp Ala His Val Val 
            340                 345                 350         


Cys Ala Leu Trp Ile Pro Glu Val Cys Phe Ala Asn Xaa Val Phe Leu 
        355                 360                 365             


Glu Pro Ile Asp Ser Ile Glu His Ile Pro Pro Ala Arg Trp Lys Leu 
    370                 375                 380                 


Xaa Cys Tyr Ile Cys Lys Gln Arg Gly Ser Gly Ala Cys Ile Gln Cys 
385                 390                 395                 400 


His Lys Ala Asn Cys Tyr Xaa Ala Phe His Val Xaa Cys Ala Gln Gln 
                405                 410                 415     


Ala Gly Leu Tyr Met Lys Met Glu Pro Val Arg Glu Xaa Gly Ala Asn 
            420                 425                 430         


Gly Xaa Ser Phe Ser Val Arg Lys Xaa Ala Tyr Cys Asp Ile His Xaa 
        435                 440                 445             


Pro Pro Gly Ser Ala Arg Arg Leu Pro Ala Leu Ser His Ser Glu Gly 
    450                 455                 460                 


Glu Glu Asp Glu Asp Glu Glu Glu Asp Glu Gly Lys Gly Trp Ser Ser 
465                 470                 475                 480 


Glu Lys Val Lys Lys Ala Lys Ala Lys Ser Arg Ile Lys Met Lys Lys 
                485                 490                 495     


Ala Arg Lys Ile Leu Ala Glu Lys Arg Ala Ala Ala Pro Val Val Ser 
            500                 505                 510         


Val Pro Cys Ile Pro Pro His Arg Leu Ser Lys Ile Xaa Asn Arg Leu 
        515                 520                 525             


Xaa Ile Gln Arg Lys Ser Gln Phe Met Gln Arg Leu His Ser Tyr Trp 
    530                 535                 540                 


Xaa Leu Lys Arg Gln Ser Arg Asn Gly Val Pro Leu Leu Arg Arg Leu 
545                 550                 555                 560 


Gln Xaa His Leu Gln Ser Gln Arg Asn Cys Asp Gln Val Gly Arg Asp 
                565                 570                 575     


Ser Glu Asp Lys Asn Trp Ala Leu Lys Glu Gln Leu Lys Ser Trp Gln 
            580                 585                 590         


Arg Leu Arg His Asp Leu Glu Arg Ala Arg Leu Leu Val Glu Leu Ile 
        595                 600                 605             


Arg Lys Arg Glu Lys Leu Lys Arg Glu Xaa Ile Lys Val Gln Gln Ile 
    610                 615                 620                 


Ala Met Glu Met Gln Leu Xaa Pro Phe Leu Ile Leu Leu Arg Lys Xaa 
625                 630                 635                 640 


Leu Glu Gln Leu Gln Glu Lys Asp Xaa Gly Asn Ile Phe Ser Glu Pro 
                645                 650                 655     


Val Pro Leu Ser Glu Val Xaa Glu Leu Asp Glu Val Pro Asp Tyr Leu 
            660                 665                 670         


Asp His Ile Lys Lys Pro Met Asp Phe Phe Xaa Met Lys Gln Asn Leu 
        675                 680                 685             


Glu Ala Tyr Arg Tyr Leu Asn Phe Asp Asp Phe Glu Glu Asp Phe Asn 
    690                 695                 700                 


Leu Ile Val Ser Asn Cys Leu Lys Tyr Asn Ala Lys Asp Xaa Ile Phe 
705                 710                 715                 720 


Tyr Arg Ala Ala Val Arg Leu Arg Glu Gln Gly Gly Ala Val Leu Arg 
                725                 730                 735     


Gln Ala Arg Arg Gln Ala Glu Lys Met Gly Ile Asp Phe Glu Xaa Gly 
            740                 745                 750         


Met His Ile Pro His Ser Leu Ala Gly Asp Glu Ala Xaa His His Xaa 
        755                 760                 765             


Glu Asp Ala Ala Glu Glu Glu Arg Leu Val Leu Leu Glu Asn Gln Lys 
    770                 775                 780                 


His Leu Pro Val Glu Glu Gln Leu Lys Leu Leu Leu Glu Arg Leu Asp 
785                 790                 795                 800 


Glu Val Asn Ala Ser Lys Gln Ser Val Gly Arg Ser Arg Arg Ala Lys 
                805                 810                 815     


Met Ile Lys Lys Glu Met Xaa Ala Leu Arg Arg Lys Leu Ala His Gln 
            820                 825                 830         


Arg Glu Xaa Gly Arg Asp Gly Pro Glu Arg His Gly Pro Ser Ser Arg 
        835                 840                 845             


Gly Ser Leu Xaa Pro His Pro Ala Ala Cys Asp Lys Asp Gly Gln Xaa 
    850                 855                 860                 


Asp Ser Ala Ala Glu Glu Ser Ser Ser Gln Glu Xaa Ser Lys Gly Leu 
865                 870                 875                 880 


Gly Pro Asn Met Ser Ser Xaa Pro Ala His Glu Val Gly Arg Arg Xaa 
                885                 890                 895     


Ser Val Leu Phe Ser Lys Lys Asn Pro Lys Xaa Ala Gly Pro Pro Lys 
            900                 905                 910         


Arg Pro Gly Arg Pro Pro Lys Asn Arg Glu Ser Gln Met Xaa Pro Ser 
        915                 920                 925             


His Gly Gly Ser Pro Val Gly Pro Pro Gln Leu Pro Ile Met Ser Ser 
    930                 935                 940                 


Leu Arg Gln Arg Lys Arg Gly Arg Ser Pro Arg Pro Ser Ser Ser Ser 
945                 950                 955                 960 


Asp Ser Asp Ser Asp Lys Ser Xaa Glu Asp Pro Pro Met Asp Leu Pro 
                965                 970                 975     


Ala Asn Gly Phe Ser Gly Gly Asn Gln Pro Val Lys Lys Ser Phe Leu 
            980                 985                 990         


Val Tyr Arg Asn Asp Cys Ser Leu  Pro Arg Ser Ser Ser  Asp Ser Glu 
        995                 1000                 1005             


Ser Ser  Ser Ser Ser Ser Ser  Ser Ala Ala Ser Asp  Arg Xaa Ser 
    1010                 1015                 1020             


Xaa Xaa  Pro Ser Lys Gln Gly  Arg Gly Lys Pro Ser  Phe Ser Arg 
    1025                 1030                 1035             


Gly Xaa  Phe Pro Glu Asp Ser  Ser Glu Asp Xaa Ser  Gly Xaa Glu 
    1040                 1045                 1050             


Asn Glu  Ala Tyr Ser Val Gly  Xaa Gly Arg Gly Val  Gly His Ser 
    1055                 1060                 1065             


Met Val  Arg Lys Ser Leu Gly  Arg Gly Ala Gly Trp  Leu Ser Glu 
    1070                 1075                 1080             


Asp Glu  Asp Ser Pro Leu Asp  Ala Leu Asp Leu Val  Trp Ala Lys 
    1085                 1090                 1095             


Cys Arg  Gly Tyr Pro Ser Tyr  Pro Ala Leu Ile Ile  Asp Pro Lys 
    1100                 1105                 1110             


Met Pro  Arg Glu Gly Met Phe  His His Gly Val Pro  Ile Pro Val 
    1115                 1120                 1125             


Pro Pro  Leu Glu Val Leu Lys  Leu Gly Glu Gln Met  Xaa Gln Glu 
    1130                 1135                 1140             


Ala Arg  Glu His Leu Tyr Leu  Val Leu Phe Phe Asp  Asn Lys Arg 
    1145                 1150                 1155             


Xaa Trp  Gln Trp Leu Pro Arg  Xaa Lys Leu Val Pro  Leu Gly Val 
    1160                 1165                 1170             


Asn Gln  Asp Leu Asp Lys Glu  Lys Met Leu Glu Gly  Arg Lys Ser 
    1175                 1180                 1185             


Asn Ile  Arg Lys Ser Val Gln  Ile Ala Tyr His Arg  Ala Leu Gln 
    1190                 1195                 1200             


His Arg  Ser Lys Val Gln Gly  Glu Gln Ser Ser Glu  Xaa Ser Asp 
    1205                 1210                 1215             


Ser Asp  
    1220 


<210> 4452
<211> 399
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<400> 4452
Met Ala Gln Arg Gln Pro His Ser Pro Asn Gln Xaa Leu Ile Ser Ile 
1               5                   10                  15      


Xaa Asn Asp Xaa Glu Ser Ser Ser Ser Val Val Ser Asn Asp Asn Xaa 
            20                  25                  30          


Asn Lys Gly Trp Ser Gly Asp Asn Ser Pro Gly Ile Glu Ala Leu Cys 
        35                  40                  45              


Ala Ile Tyr Ile Xaa Tyr Ala Val Ile Ile Ser Val Gly Ile Leu Gly 
    50                  55                  60                  


Asn Ala Ile Leu Ile Lys Val Phe Phe Lys Xaa Lys Ser Met Gln Xaa 
65                  70                  75                  80  


Val Pro Asn Ile Phe Ile Xaa Ser Leu Ala Phe Gly Asp Leu Leu Leu 
                85                  90                  95      


Leu Leu Xaa Cys Val Pro Val Asp Ala Xaa His Tyr Leu Ala Glu Gly 
            100                 105                 110         


Trp Leu Phe Gly Arg Ile Gly Cys Lys Val Leu Ser Phe Ile Arg Leu 
        115                 120                 125             


Xaa Ser Val Gly Val Ser Val Phe Xaa Leu Xaa Ile Leu Ser Ala Asp 
    130                 135                 140                 


Arg Tyr Lys Ala Val Val Lys Pro Leu Glu Arg Gln Pro Ser Asn Ala 
145                 150                 155                 160 


Ile Leu Lys Xaa Cys Val Lys Ala Gly Cys Val Trp Ile Val Ser Met 
                165                 170                 175     


Ile Phe Ala Leu Pro Glu Ala Ile Phe Ser Asn Val Tyr Xaa Phe Arg 
            180                 185                 190         


Asp Pro Asn Lys Asn Met Xaa Phe Glu Ser Cys Xaa Ser Tyr Pro Val 
        195                 200                 205             


Ser Lys Lys Leu Leu Gln Glu Ile His Ser Leu Leu Cys Phe Leu Val 
    210                 215                 220                 


Phe Tyr Ile Ile Pro Leu Ser Ile Ile Ser Val Tyr Tyr Ser Leu Ile 
225                 230                 235                 240 


Ala Arg Xaa Leu Tyr Lys Ser Xaa Leu Asn Ile Pro Xaa Glu Glu Gln 
                245                 250                 255     


Ser His Ala Arg Lys Gln Ile Glu Ser Arg Lys Arg Ile Ala Arg Xaa 
            260                 265                 270         


Val Leu Val Leu Val Ala Leu Phe Ala Leu Cys Trp Leu Pro Asn His 
        275                 280                 285             


Leu Leu Tyr Leu Tyr His Ser Phe Xaa Ser Gln Xaa Tyr Val Asp Pro 
    290                 295                 300                 


Ser Ala Met His Phe Ile Phe Xaa Ile Phe Ser Arg Val Leu Ala Phe 
305                 310                 315                 320 


Ser Asn Ser Cys Val Asn Pro Phe Ala Leu Tyr Trp Leu Ser Lys Ser 
                325                 330                 335     


Phe Gln Lys His Phe Lys Ala Gln Leu Phe Cys Cys Lys Ala Glu Arg 
            340                 345                 350         


Pro Glu Pro Pro Val Ala Asp Xaa Ser Leu Xaa Xaa Leu Ala Val Met 
        355                 360                 365             


Gly Xaa Val Pro Gly Xaa Gly Ser Ile Gln Met Ser Glu Ile Ser Val 
    370                 375                 380                 


Xaa Ser Phe Xaa Gly Cys Ser Val Lys Gln Ala Glu Asp Arg Phe 
385                 390                 395                 


<210> 4453
<211> 132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<400> 4453
Met Arg Ser Leu Pro Ser Asn Gly Glu Leu Asp Pro Asp Val Leu Glu 
1               5                   10                  15      


Ser Met Ala Ser Leu Gly Cys Phe Arg Asp Arg Glu Arg Leu His Arg 
            20                  25                  30          


Glu Leu Arg Ser Glu Glu Glu Asn Gln Glu Lys Met Ile Tyr Tyr Leu 
        35                  40                  45              


Leu Leu Asp Arg Lys Glu Arg Tyr Pro Ser Cys Glu Asp Gln Asp Leu 
    50                  55                  60                  


Pro Pro Arg Asn Asp Val Asp Pro Pro Arg Lys Arg Val Asp Ser Pro 
65                  70                  75                  80  


Met Leu Ser Arg His Gly Lys Arg Arg Pro Glu Arg Lys Ser Met Glu 
                85                  90                  95      


Val Leu Ser Ile Xaa Asp Ala Gly Gly Gly Gly Ser Pro Val Pro Xaa 
            100                 105                 110         


Arg Arg Ala Leu Glu Met Ala Gln His Ser Gln Arg Ser Arg Ser Val 
        115                 120                 125             


Ser Gly Ala Ser 
    130         


<210> 4454
<211> 473
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<400> 4454
Met Arg Ser Leu Pro Ser Asn Gly Glu Leu Asp Pro Asp Val Leu Glu 
1               5                   10                  15      


Ser Met Ala Ser Leu Gly Cys Phe Arg Asp Arg Glu Arg Leu His Arg 
            20                  25                  30          


Glu Leu Arg Ser Glu Glu Glu Asn Gln Glu Lys Met Ile Tyr Tyr Leu 
        35                  40                  45              


Leu Leu Asp Arg Lys Glu Arg Tyr Pro Ser Cys Glu Asp Gln Asp Leu 
    50                  55                  60                  


Pro Pro Arg Asn Asp Val Asp Pro Pro Arg Lys Arg Val Asp Ser Pro 
65                  70                  75                  80  


Met Leu Ser Arg His Gly Lys Arg Arg Pro Glu Arg Lys Ser Met Glu 
                85                  90                  95      


Val Leu Ser Ile Xaa Asp Ala Gly Gly Gly Gly Ser Pro Val Pro Xaa 
            100                 105                 110         


Arg Arg Ala Leu Glu Met Ala Gln His Ser Gln Arg Ser Arg Ser Val 
        115                 120                 125             


Ser Gly Ala Ser Xaa Gly Leu Ser Ser Ser Pro Leu Ser Ser Pro Arg 
    130                 135                 140                 


Ser Pro Val Phe Ser Phe Ser Pro Glu Pro Gly Ala Gly Asp Glu Ala 
145                 150                 155                 160 


Arg Gly Gly Gly Ser Pro Xaa Ser Lys Xaa Gln Xaa Leu Pro Ser Arg 
                165                 170                 175     


Gly Pro Arg Gly Gly Gly Ala Gly Glu Gln Pro Pro Pro Pro Ser Ala 
            180                 185                 190         


Arg Ser Xaa Pro Leu Pro Gly Pro Pro Gly Ser Pro Arg Ser Ser Gly 
        195                 200                 205             


Gly Xaa Pro Leu His Ser Pro Leu His Xaa Pro Arg Ala Ser Pro Xaa 
    210                 215                 220                 


Gly Xaa Pro Gly Xaa Xaa Pro Pro Pro Ser Pro Gly Gly Gly Val Gly 
225                 230                 235                 240 


Gly Ala Ala Trp Arg Ser Arg Leu Asn Ser Ile Arg Asn Ser Phe Leu 
                245                 250                 255     


Gly Ser Pro Arg Phe His Arg Arg Lys Met Gln Val Pro Xaa Ala Glu 
            260                 265                 270         


Glu Met Ser Ser Leu Xaa Pro Glu Ser Ser Pro Glu Leu Ala Lys Arg 
        275                 280                 285             


Ser Trp Phe Gly Asn Phe Ile Ser Leu Asp Lys Glu Glu Gln Ile Phe 
    290                 295                 300                 


Leu Val Leu Lys Asp Lys Pro Leu Ser Ser Ile Lys Ala Asp Ile Val 
305                 310                 315                 320 


His Ala Phe Leu Ser Ile Pro Ser Leu Ser His Ser Val Leu Ser Gln 
                325                 330                 335     


Xaa Ser Phe Arg Ala Glu Tyr Lys Ala Ser Gly Gly Pro Ser Val Phe 
            340                 345                 350         


Gln Lys Pro Val Arg Phe Gln Val Asp Ile Ser Ser Ser Glu Gly Pro 
        355                 360                 365             


Glu Pro Ser Pro Arg Arg Asp Gly Ser Gly Gly Gly Gly Ile Tyr Ser 
    370                 375                 380                 


Val Xaa Phe Xaa Leu Ile Ser Gly Pro Ser Arg Arg Phe Lys Arg Val 
385                 390                 395                 400 


Val Glu Xaa Ile Gln Ala Gln Leu Leu Ser Xaa His Asp Gln Pro Ser 
                405                 410                 415     


Val Gln Ala Leu Ala Asp Glu Lys Asn Gly Ala Gln Xaa Arg Pro Ala 
            420                 425                 430         


Gly Ala Pro Pro Arg Ser Leu Gln Pro Pro Pro Gly Arg Pro Asp Pro 
        435                 440                 445             


Glu Leu Ser Ser Ser Pro Arg Arg Gly Pro Pro Lys Asp Lys Lys Leu 
    450                 455                 460                 


Leu Ala Xaa Asn Gly Xaa Pro Leu Pro 
465                 470             


<210> 4455
<211> 343
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<400> 4455
Met Ser Ser Gly Ala Lys Glu Gly Gly Gly Gly Ser Pro Ala Tyr His 
1               5                   10                  15      


Leu Pro His Pro His Pro His Pro Pro Gln His Ala Gln Tyr Val Gly 
            20                  25                  30          


Pro Tyr Arg Leu Glu Lys Xaa Leu Gly Lys Gly Gln Xaa Gly Leu Val 
        35                  40                  45              


Lys Leu Gly Val His Cys Ile Xaa Gly Gln Lys Val Ala Ile Lys Ile 
    50                  55                  60                  


Val Asn Arg Glu Lys Leu Ser Glu Ser Val Leu Met Lys Val Glu Arg 
65                  70                  75                  80  


Glu Ile Ala Ile Leu Lys Leu Ile Glu His Pro His Val Leu Lys Leu 
                85                  90                  95      


His Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr Leu Val Leu Glu His 
            100                 105                 110         


Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val Lys Lys Gly Arg Leu 
        115                 120                 125             


Xaa Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln Ile Val Ser Ala Leu 
    130                 135                 140                 


Asp Phe Cys His Ser Tyr Ser Ile Cys His Arg Asp Leu Lys Pro Glu 
145                 150                 155                 160 


Asn Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg Ile Ala Asp Phe Gly 
                165                 170                 175     


Met Ala Ser Leu Gln Val Gly Asp Ser Leu Leu Glu Xaa Ser Cys Gly 
            180                 185                 190         


Ser Pro His Tyr Ala Cys Pro Glu Val Ile Lys Gly Glu Lys Tyr Asp 
        195                 200                 205             


Gly Arg Arg Ala Asp Met Trp Ser Cys Gly Val Ile Leu Phe Ala Leu 
    210                 215                 220                 


Leu Val Gly Ala Leu Pro Phe Asp Asp Asp Asn Leu Arg Gln Leu Leu 
225                 230                 235                 240 


Glu Lys Val Lys Arg Gly Val Phe His Met Pro His Phe Ile Pro Pro 
                245                 250                 255     


Asp Cys Gln Ser Leu Leu Arg Gly Met Ile Glu Val Glu Pro Glu Lys 
            260                 265                 270         


Arg Leu Ser Leu Glu Gln Ile Gln Lys His Pro Trp Tyr Leu Gly Gly 
        275                 280                 285             


Lys His Glu Pro Asp Pro Cys Leu Glu Pro Ala Pro Gly Arg Arg Val 
    290                 295                 300                 


Ala Met Arg Ser Leu Pro Ser Asn Gly Glu Leu Asp Pro Asp Val Leu 
305                 310                 315                 320 


Glu Ser Met Ala Ser Leu Gly Cys Phe Arg Asp Arg Glu Arg Leu His 
                325                 330                 335     


Arg Glu Leu Arg Ser Glu Glu 
            340             


<210> 4456
<211> 778
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<400> 4456
Met Ser Ser Gly Ala Lys Glu Gly Gly Gly Gly Ser Pro Ala Tyr His 
1               5                   10                  15      


Leu Pro His Pro His Pro His Pro Pro Gln His Ala Gln Tyr Val Gly 
            20                  25                  30          


Pro Tyr Arg Leu Glu Lys Xaa Leu Gly Lys Gly Gln Xaa Gly Leu Val 
        35                  40                  45              


Lys Leu Gly Val His Cys Ile Xaa Gly Gln Lys Val Ala Ile Lys Ile 
    50                  55                  60                  


Val Asn Arg Glu Lys Leu Ser Glu Ser Val Leu Met Lys Val Glu Arg 
65                  70                  75                  80  


Glu Ile Ala Ile Leu Lys Leu Ile Glu His Pro His Val Leu Lys Leu 
                85                  90                  95      


His Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr Leu Val Leu Glu His 
            100                 105                 110         


Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val Lys Lys Gly Arg Leu 
        115                 120                 125             


Xaa Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln Ile Val Ser Ala Leu 
    130                 135                 140                 


Asp Phe Cys His Ser Tyr Ser Ile Cys His Arg Asp Leu Lys Pro Glu 
145                 150                 155                 160 


Asn Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg Ile Ala Asp Phe Gly 
                165                 170                 175     


Met Ala Ser Leu Gln Val Gly Asp Ser Leu Leu Glu Xaa Ser Cys Gly 
            180                 185                 190         


Ser Pro His Tyr Ala Cys Pro Glu Val Ile Lys Gly Glu Lys Tyr Asp 
        195                 200                 205             


Gly Arg Arg Ala Asp Met Trp Ser Cys Gly Val Ile Leu Phe Ala Leu 
    210                 215                 220                 


Leu Val Gly Ala Leu Pro Phe Asp Asp Asp Asn Leu Arg Gln Leu Leu 
225                 230                 235                 240 


Glu Lys Val Lys Arg Gly Val Phe His Met Pro His Phe Ile Pro Pro 
                245                 250                 255     


Asp Cys Gln Ser Leu Leu Arg Gly Met Ile Glu Val Glu Pro Glu Lys 
            260                 265                 270         


Arg Leu Ser Leu Glu Gln Ile Gln Lys His Pro Trp Tyr Leu Gly Gly 
        275                 280                 285             


Lys His Glu Pro Asp Pro Cys Leu Glu Pro Ala Pro Gly Arg Arg Val 
    290                 295                 300                 


Ala Met Arg Ser Leu Pro Ser Asn Gly Glu Leu Asp Pro Asp Val Leu 
305                 310                 315                 320 


Glu Ser Met Ala Ser Leu Gly Cys Phe Arg Asp Arg Glu Arg Leu His 
                325                 330                 335     


Arg Glu Leu Arg Ser Glu Glu Glu Asn Gln Glu Lys Met Ile Tyr Tyr 
            340                 345                 350         


Leu Leu Leu Asp Arg Lys Glu Arg Tyr Pro Ser Cys Glu Asp Gln Asp 
        355                 360                 365             


Leu Pro Pro Arg Asn Asp Val Asp Pro Pro Arg Lys Arg Val Asp Ser 
    370                 375                 380                 


Pro Met Leu Ser Arg His Gly Lys Arg Arg Pro Glu Arg Lys Ser Met 
385                 390                 395                 400 


Glu Val Leu Ser Ile Xaa Asp Ala Gly Gly Gly Gly Ser Pro Val Pro 
                405                 410                 415     


Xaa Arg Arg Ala Leu Glu Met Ala Gln His Ser Gln Arg Ser Arg Ser 
            420                 425                 430         


Val Ser Gly Ala Ser Xaa Gly Leu Ser Ser Ser Pro Leu Ser Ser Pro 
        435                 440                 445             


Arg Ser Pro Val Phe Ser Phe Ser Pro Glu Pro Gly Ala Gly Asp Glu 
    450                 455                 460                 


Ala Arg Gly Gly Gly Ser Pro Xaa Ser Lys Xaa Gln Xaa Leu Pro Ser 
465                 470                 475                 480 


Arg Gly Pro Arg Gly Gly Gly Ala Gly Glu Gln Pro Pro Pro Pro Ser 
                485                 490                 495     


Ala Arg Ser Xaa Pro Leu Pro Gly Pro Pro Gly Ser Pro Arg Ser Ser 
            500                 505                 510         


Gly Gly Xaa Pro Leu His Ser Pro Leu His Xaa Pro Arg Ala Ser Pro 
        515                 520                 525             


Xaa Gly Xaa Pro Gly Xaa Xaa Pro Pro Pro Ser Pro Gly Gly Gly Val 
    530                 535                 540                 


Gly Gly Ala Ala Trp Arg Ser Arg Leu Asn Ser Ile Arg Asn Ser Phe 
545                 550                 555                 560 


Leu Gly Ser Pro Arg Phe His Arg Arg Lys Met Gln Val Pro Xaa Ala 
                565                 570                 575     


Glu Glu Met Ser Ser Leu Xaa Pro Glu Ser Ser Pro Glu Leu Ala Lys 
            580                 585                 590         


Arg Ser Trp Phe Gly Asn Phe Ile Ser Leu Asp Lys Glu Glu Gln Ile 
        595                 600                 605             


Phe Leu Val Leu Lys Asp Lys Pro Leu Ser Ser Ile Lys Ala Asp Ile 
    610                 615                 620                 


Val His Ala Phe Leu Ser Ile Pro Ser Leu Ser His Ser Val Leu Ser 
625                 630                 635                 640 


Gln Xaa Ser Phe Arg Ala Glu Tyr Lys Ala Ser Gly Gly Pro Ser Val 
                645                 650                 655     


Phe Gln Lys Pro Val Arg Phe Gln Val Asp Ile Ser Ser Ser Glu Gly 
            660                 665                 670         


Pro Glu Pro Ser Pro Arg Arg Asp Gly Ser Gly Gly Gly Gly Ile Tyr 
        675                 680                 685             


Ser Val Xaa Phe Xaa Leu Ile Ser Gly Pro Ser Arg Arg Phe Lys Arg 
    690                 695                 700                 


Val Val Glu Xaa Ile Gln Ala Gln Leu Leu Ser Xaa His Asp Gln Pro 
705                 710                 715                 720 


Ser Val Gln Ala Leu Ala Asp Glu Lys Asn Gly Ala Gln Xaa Arg Pro 
                725                 730                 735     


Ala Gly Ala Pro Pro Arg Ser Leu Gln Pro Pro Pro Gly Arg Pro Asp 
            740                 745                 750         


Pro Glu Leu Ser Ser Ser Pro Arg Arg Gly Pro Pro Lys Asp Lys Lys 
        755                 760                 765             


Leu Leu Ala Xaa Asn Gly Xaa Pro Leu Pro 
    770                 775             


<210> 4457
<211> 794
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<400> 4457
Met Val Ala Gly Leu Xaa Leu Gly Lys Gly Pro Glu Ser Pro Asp Gly 
1               5                   10                  15      


Asp Val Ser Val Pro Glu Arg Lys Asp Glu Val Ala Gly Gly Gly Gly 
            20                  25                  30          


Glu Glu Glu Glu Ala Glu Glu Arg Gly Arg His Ala Gln Tyr Val Gly 
        35                  40                  45              


Pro Tyr Arg Leu Glu Lys Xaa Leu Gly Lys Gly Gln Xaa Gly Leu Val 
    50                  55                  60                  


Lys Leu Gly Val His Cys Ile Xaa Gly Gln Lys Val Ala Ile Lys Ile 
65                  70                  75                  80  


Val Asn Arg Glu Lys Leu Ser Glu Ser Val Leu Met Lys Val Glu Arg 
                85                  90                  95      


Glu Ile Ala Ile Leu Lys Leu Ile Glu His Pro His Val Leu Lys Leu 
            100                 105                 110         


His Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr Leu Val Leu Glu His 
        115                 120                 125             


Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val Lys Lys Gly Arg Leu 
    130                 135                 140                 


Xaa Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln Ile Val Ser Ala Leu 
145                 150                 155                 160 


Asp Phe Cys His Ser Tyr Ser Ile Cys His Arg Asp Leu Lys Pro Glu 
                165                 170                 175     


Asn Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg Ile Ala Asp Phe Gly 
            180                 185                 190         


Met Ala Ser Leu Gln Val Gly Asp Ser Leu Leu Glu Xaa Ser Cys Gly 
        195                 200                 205             


Ser Pro His Tyr Ala Cys Pro Glu Val Ile Lys Gly Glu Lys Tyr Asp 
    210                 215                 220                 


Gly Arg Arg Ala Asp Met Trp Ser Cys Gly Val Ile Leu Phe Ala Leu 
225                 230                 235                 240 


Leu Val Gly Ala Leu Pro Phe Asp Asp Asp Asn Leu Arg Gln Leu Leu 
                245                 250                 255     


Glu Lys Val Lys Arg Gly Val Phe His Met Pro His Phe Ile Pro Pro 
            260                 265                 270         


Asp Cys Gln Ser Leu Leu Arg Gly Met Ile Glu Val Glu Pro Glu Lys 
        275                 280                 285             


Arg Leu Ser Leu Glu Gln Ile Gln Lys His Pro Trp Tyr Leu Gly Gly 
    290                 295                 300                 


Lys His Glu Pro Asp Pro Cys Leu Glu Pro Ala Pro Gly Arg Arg Val 
305                 310                 315                 320 


Ala Met Arg Ser Leu Pro Ser Asn Gly Glu Leu Asp Pro Asp Val Leu 
                325                 330                 335     


Glu Ser Met Ala Ser Leu Gly Cys Phe Arg Asp Arg Glu Arg Leu His 
            340                 345                 350         


Arg Glu Leu Arg Ser Glu Glu Glu Asn Gln Glu Lys Met Ile Tyr Tyr 
        355                 360                 365             


Leu Leu Leu Asp Arg Lys Glu Arg Tyr Pro Ser Cys Glu Asp Gln Asp 
    370                 375                 380                 


Leu Pro Pro Arg Asn Asp Val Asp Pro Pro Arg Lys Arg Val Asp Ser 
385                 390                 395                 400 


Pro Met Leu Ser Arg His Gly Lys Arg Arg Pro Glu Arg Lys Ser Met 
                405                 410                 415     


Glu Val Leu Ser Ile Xaa Asp Ala Gly Gly Gly Gly Ser Pro Val Pro 
            420                 425                 430         


Xaa Arg Arg Ala Leu Glu Met Ala Gln His Ser Gln Arg Ser Arg Ser 
        435                 440                 445             


Val Ser Gly Ala Ser Xaa Gly Leu Ser Ser Ser Pro Leu Ser Ser Pro 
    450                 455                 460                 


Arg Ser Pro Val Phe Ser Phe Ser Pro Glu Pro Gly Ala Gly Asp Glu 
465                 470                 475                 480 


Ala Arg Gly Gly Gly Ser Pro Xaa Ser Lys Xaa Gln Xaa Leu Pro Ser 
                485                 490                 495     


Arg Gly Pro Arg Gly Gly Gly Ala Gly Glu Gln Pro Pro Pro Pro Ser 
            500                 505                 510         


Ala Arg Ser Xaa Pro Leu Pro Gly Pro Pro Gly Ser Pro Arg Ser Ser 
        515                 520                 525             


Gly Gly Xaa Pro Leu His Ser Pro Leu His Xaa Pro Arg Ala Ser Pro 
    530                 535                 540                 


Xaa Gly Xaa Pro Gly Xaa Xaa Pro Pro Pro Ser Pro Gly Gly Gly Val 
545                 550                 555                 560 


Gly Gly Ala Ala Trp Arg Ser Arg Leu Asn Ser Ile Arg Asn Ser Phe 
                565                 570                 575     


Leu Gly Ser Pro Arg Phe His Arg Arg Lys Met Gln Val Pro Xaa Ala 
            580                 585                 590         


Glu Glu Met Ser Ser Leu Xaa Pro Glu Ser Ser Pro Glu Leu Ala Lys 
        595                 600                 605             


Arg Ser Trp Phe Gly Asn Phe Ile Ser Leu Asp Lys Glu Glu Gln Ile 
    610                 615                 620                 


Phe Leu Val Leu Lys Asp Lys Pro Leu Ser Ser Ile Lys Ala Asp Ile 
625                 630                 635                 640 


Val His Ala Phe Leu Ser Ile Pro Ser Leu Ser His Ser Val Leu Ser 
                645                 650                 655     


Gln Xaa Ser Phe Arg Ala Glu Tyr Lys Ala Ser Gly Gly Pro Ser Val 
            660                 665                 670         


Phe Gln Lys Pro Val Arg Phe Gln Val Asp Ile Ser Ser Ser Glu Gly 
        675                 680                 685             


Pro Glu Pro Ser Pro Arg Arg Asp Gly Ser Gly Gly Gly Gly Ile Tyr 
    690                 695                 700                 


Ser Val Xaa Phe Xaa Leu Ile Ser Gly Pro Ser Arg Arg Phe Lys Arg 
705                 710                 715                 720 


Val Val Glu Xaa Ile Gln Ala Gln Leu Leu Ser Xaa His Asp Gln Pro 
                725                 730                 735     


Ser Val Gln Ala Leu Ala Asp Glu Lys Asn Gly Ala Gln Xaa Arg Pro 
            740                 745                 750         


Ala Gly Ala Pro Pro Arg Ser Leu Gln Pro Pro Pro Gly Arg Pro Asp 
        755                 760                 765             


Pro Glu Leu Ser Ser Ser Pro Arg Arg Gly Pro Pro Lys Asp Lys Lys 
    770                 775                 780                 


Leu Leu Ala Xaa Asn Gly Xaa Pro Leu Pro 
785                 790                 


<210> 4458
<211> 63
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<400> 4458
Xaa Ala Gly Leu Val Lys Leu Gly Val His Cys Ile Xaa Gly Gln Lys 
1               5                   10                  15      


Val Ala Ile Lys Ile Val Asn Arg Glu Lys Leu Ser Glu Ser Val Leu 
            20                  25                  30          


Met Lys Val Glu Arg Glu Ile Ala Ile Leu Lys Leu Ile Glu His Pro 
        35                  40                  45              


His Val Leu Lys Leu His Asp Val Tyr Glu Asn Lys Lys Tyr Leu 
    50                  55                  60              


<210> 4459
<211> 87
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<400> 4459
Met Lys Val Glu Arg Glu Ile Ala Ile Leu Lys Leu Ile Glu His Pro 
1               5                   10                  15      


His Val Leu Lys Leu His Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr 
            20                  25                  30          


Leu Val Leu Glu His Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val 
        35                  40                  45              


Lys Lys Gly Arg Leu Xaa Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln 
    50                  55                  60                  


Ile Ile Ser Ala Leu Asp Phe Cys His Ser His Ser Ile Cys His Arg 
65                  70                  75                  80  


Asp Leu Lys Pro Glu Asn Leu 
                85          


<210> 4460
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<400> 4460
Met Lys Val Glu Arg Glu Ile Ala Ile Leu Lys Leu Ile Glu His Pro 
1               5                   10                  15      


His Val Leu Lys Leu His Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr 
            20                  25                  30          


Leu Val Leu Glu His Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val 
        35                  40                  45              


Lys Lys Gly Arg Leu Xaa Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln 
    50                  55                  60                  


Ile Ile Ser Ala Leu Asp Phe Cys His Ser His Ser Ile Cys His Arg 
65                  70                  75                  80  


Asp Leu Lys Pro Glu Asn Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg 
                85                  90                  95      


Ile Ala Asp Phe Gly Met Ala Ser Leu Gln Val Gly Asp Ser Leu Leu 
            100                 105                 110         


Glu Xaa Ser Cys Gly Ser Pro His Tyr Ala Cys Pro Glu Val Ile Arg 
        115                 120                 125             


Gly Glu 
    130 


<210> 4461
<211> 614
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<400> 4461
Met Lys Val Glu Arg Glu Ile Ala Ile Leu Lys Leu Ile Glu His Pro 
1               5                   10                  15      


His Val Leu Lys Leu His Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr 
            20                  25                  30          


Leu Val Leu Glu His Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val 
        35                  40                  45              


Lys Lys Gly Arg Leu Xaa Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln 
    50                  55                  60                  


Ile Ile Ser Ala Leu Asp Phe Cys His Ser His Ser Ile Cys His Arg 
65                  70                  75                  80  


Asp Leu Lys Pro Glu Asn Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg 
                85                  90                  95      


Ile Ala Asp Phe Gly Met Ala Ser Leu Gln Val Gly Asp Ser Leu Leu 
            100                 105                 110         


Glu Xaa Ser Cys Gly Ser Pro His Tyr Ala Cys Pro Glu Val Ile Arg 
        115                 120                 125             


Gly Glu Lys Tyr Asp Gly Arg Lys Ala Asp Val Trp Ser Cys Gly Val 
    130                 135                 140                 


Ile Leu Phe Ala Leu Leu Val Gly Ala Leu Pro Phe Asp Asp Asp Asn 
145                 150                 155                 160 


Leu Arg Gln Leu Leu Glu Lys Val Lys Arg Gly Val Phe His Met Pro 
                165                 170                 175     


His Phe Ile Pro Pro Asp Cys Gln Ser Leu Leu Arg Gly Met Ile Glu 
            180                 185                 190         


Val Asp Ala Ala Arg Arg Leu Xaa Leu Glu His Ile Gln Lys His Ile 
        195                 200                 205             


Trp Tyr Ile Gly Gly Lys Asn Glu Pro Glu Pro Glu Gln Pro Ile Pro 
    210                 215                 220                 


Arg Lys Val Gln Ile Arg Ser Leu Pro Ser Leu Glu Asp Ile Asp Pro 
225                 230                 235                 240 


Asp Val Leu Asp Ser Met His Ser Leu Gly Cys Phe Arg Asp Arg Asn 
                245                 250                 255     


Lys Leu Leu Gln Asp Leu Leu Ser Glu Glu Glu Asn Gln Glu Lys Met 
            260                 265                 270         


Ile Tyr Phe Leu Leu Leu Asp Arg Lys Glu Arg Tyr Pro Ser Gln Glu 
        275                 280                 285             


Asp Glu Asp Leu Pro Pro Arg Asn Glu Ile Asp Pro Pro Arg Lys Arg 
    290                 295                 300                 


Val Asp Ser Pro Met Leu Asn Arg His Gly Lys Arg Arg Pro Glu Arg 
305                 310                 315                 320 


Lys Ser Met Glu Val Leu Ser Val Xaa Asp Gly Gly Ser Pro Val Pro 
                325                 330                 335     


Ala Arg Arg Ala Ile Glu Met Ala Gln His Gly Gln Arg Ser Arg Ser 
            340                 345                 350         


Ile Ser Gly Ala Ser Ser Gly Leu Ser Xaa Ser Pro Leu Ser Ser Pro 
        355                 360                 365             


Arg Val Xaa Pro His Pro Ser Pro Arg Gly Ser Pro Leu Pro Xaa Pro 
    370                 375                 380                 


Lys Gly Xaa Pro Val His Xaa Pro Lys Glu Ser Pro Ala Gly Xaa Pro 
385                 390                 395                 400 


Asn Pro Xaa Pro Pro Ser Ser Pro Ser Val Gly Gly Val Pro Trp Arg 
                405                 410                 415     


Ala Arg Leu Asn Ser Ile Lys Asn Ser Phe Leu Gly Ser Pro Arg Phe 
            420                 425                 430         


His Arg Arg Lys Leu Gln Val Pro Xaa Pro Glu Glu Met Ser Asn Leu 
        435                 440                 445             


Xaa Pro Glu Ser Ser Pro Glu Leu Ala Lys Lys Ser Trp Phe Gly Asn 
    450                 455                 460                 


Phe Ile Ser Leu Glu Lys Glu Glu Gln Ile Phe Val Val Ile Lys Asp 
465                 470                 475                 480 


Lys Pro Leu Ser Ser Ile Lys Ala Asp Ile Val His Ala Phe Leu Ser 
                485                 490                 495     


Ile Pro Ser Leu Ser His Ser Val Ile Ser Gln Xaa Ser Phe Arg Ala 
            500                 505                 510         


Glu Tyr Lys Ala Xaa Gly Gly Pro Ala Val Phe Gln Lys Pro Val Lys 
        515                 520                 525             


Phe Gln Val Asp Ile Xaa Tyr Xaa Glu Gly Gly Glu Ala Gln Lys Glu 
    530                 535                 540                 


Asn Gly Ile Tyr Ser Val Xaa Phe Xaa Leu Leu Ser Gly Pro Ser Arg 
545                 550                 555                 560 


Arg Phe Lys Arg Val Val Glu Xaa Ile Gln Ala Gln Leu Leu Ser Xaa 
                565                 570                 575     


His Asp Pro Pro Ala Ala Gln His Leu Ser Glu Pro Pro Pro Pro Ala 
            580                 585                 590         


Pro Gly Leu Ser Trp Gly Ala Gly Leu Lys Gly Gln Lys Val Ala Xaa 
        595                 600                 605             


Ser Tyr Glu Ser Ser Leu 
    610                 


<210> 4462
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<400> 4462
Met Ser Asn Leu Xaa Pro Glu Ser Ser Pro Glu Leu Ala Lys Lys Ser 
1               5                   10                  15      


Trp Phe Gly Asn Phe Ile Ser Leu Glu Lys Glu Glu Gln Ile Phe Val 
            20                  25                  30          


Val Ile Lys Asp Lys Pro Leu Ser Ser Ile Lys Ala Asp Ile Val His 
        35                  40                  45              


Ala Phe Leu Ser Ile Pro Ser Leu Ser His Ser Val Ile Ser Gln Xaa 
    50                  55                  60                  


Ser Phe Arg Ala Glu Tyr Lys Ala Xaa Gly Gly Pro Ala Val Phe Gln 
65                  70                  75                  80  


Lys Pro Val Lys Phe Gln Val Asp Ile Xaa Tyr Xaa Glu Gly Gly Glu 
                85                  90                  95      


Ala Gln Lys Glu Asn Gly Ile Tyr Ser Val Xaa Phe Xaa Leu Leu Ser 
            100                 105                 110         


Gly Pro Ser Arg Arg Phe Lys Arg Val Val Glu Xaa Ile Gln Ala Gln 
        115                 120                 125             


Leu Leu Ser Xaa His Asp Pro Pro Ala Ala Gln His Leu Ser Glu Pro 
    130                 135                 140                 


Pro Pro Pro Ala Pro Gly Leu Ser Trp Gly Ala Gly Leu Lys Gly Gln 
145                 150                 155                 160 


Lys Val Ala Xaa Ser Tyr Glu Ser Ser Leu 
                165                 170 


<210> 4463
<211> 766
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<400> 4463
Met Ser Pro Glu Gly His Pro Ser Arg Trp Ala Arg Pro Arg Arg Pro 
1               5                   10                  15      


Cys Ile Cys Pro Ser Ser Leu Cys Ser Pro Arg Glu Pro Arg Ser Gly 
            20                  25                  30          


Pro Ala Val Gly Arg Gly Gly Ala Ala His His Arg Val Pro Ala Gly 
        35                  40                  45              


His Xaa Pro Gly Pro Gln Leu Leu Gln Pro His Leu His Leu Pro Gln 
    50                  55                  60                  


Gly Gln Xaa Trp Leu Cys Leu Gln Pro Ser Pro Ala Gly Leu Val Lys 
65                  70                  75                  80  


Leu Gly Val His Cys Val Xaa Cys Gln Lys Val Ala Ile Lys Ile Val 
                85                  90                  95      


Asn Arg Glu Lys Leu Ser Glu Ser Val Leu Met Lys Val Glu Arg Glu 
            100                 105                 110         


Ile Ala Ile Leu Lys Leu Ile Glu His Pro His Val Leu Lys Leu His 
        115                 120                 125             


Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr Leu Val Leu Glu His Val 
    130                 135                 140                 


Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val Lys Lys Gly Arg Leu Xaa 
145                 150                 155                 160 


Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln Ile Ile Ser Ala Leu Asp 
                165                 170                 175     


Phe Cys His Ser His Ser Ile Cys His Arg Asp Leu Lys Pro Glu Asn 
            180                 185                 190         


Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg Ile Ala Asp Phe Gly Met 
        195                 200                 205             


Ala Ser Leu Gln Val Gly Asp Ser Leu Leu Glu Xaa Ser Cys Gly Ser 
    210                 215                 220                 


Pro His Tyr Ala Cys Pro Glu Val Ile Arg Gly Glu Lys Tyr Asp Gly 
225                 230                 235                 240 


Arg Lys Ala Asp Val Trp Ser Cys Gly Val Ile Leu Phe Ala Leu Leu 
                245                 250                 255     


Val Gly Ala Leu Pro Phe Asp Asp Asp Asn Leu Arg Gln Leu Leu Glu 
            260                 265                 270         


Lys Val Lys Arg Gly Val Phe His Met Pro His Phe Ile Pro Pro Asp 
        275                 280                 285             


Cys Gln Ser Leu Leu Arg Gly Met Ile Glu Val Asp Ala Ala Arg Arg 
    290                 295                 300                 


Leu Xaa Leu Glu His Ile Gln Lys His Ile Trp Tyr Ile Gly Gly Lys 
305                 310                 315                 320 


Asn Glu Pro Glu Pro Glu Gln Pro Ile Pro Arg Lys Val Gln Ile Arg 
                325                 330                 335     


Ser Leu Pro Ser Leu Glu Asp Ile Asp Pro Asp Val Leu Asp Ser Met 
            340                 345                 350         


His Ser Leu Gly Cys Phe Arg Asp Arg Asn Lys Leu Leu Gln Asp Leu 
        355                 360                 365             


Leu Ser Glu Glu Glu Asn Gln Glu Lys Met Ile Tyr Phe Leu Leu Leu 
    370                 375                 380                 


Asp Arg Lys Glu Arg Tyr Pro Ser Gln Glu Asp Glu Asp Leu Pro Pro 
385                 390                 395                 400 


Arg Asn Glu Ile Asp Pro Pro Arg Lys Arg Val Asp Ser Pro Met Leu 
                405                 410                 415     


Asn Arg His Gly Lys Arg Arg Pro Glu Arg Lys Ser Met Glu Val Leu 
            420                 425                 430         


Ser Val Xaa Asp Gly Gly Ser Pro Val Pro Ala Arg Arg Ala Ile Glu 
        435                 440                 445             


Met Ala Gln His Gly Gln Arg Ser Arg Ser Ile Ser Gly Ala Ser Ser 
    450                 455                 460                 


Gly Leu Ser Xaa Ser Pro Leu Ser Ser Pro Arg Val Xaa Pro His Pro 
465                 470                 475                 480 


Ser Pro Arg Gly Ser Pro Leu Pro Xaa Pro Lys Gly Xaa Pro Val His 
                485                 490                 495     


Xaa Pro Lys Glu Ser Pro Ala Gly Xaa Pro Asn Pro Xaa Pro Pro Ser 
            500                 505                 510         


Ser Pro Ser Val Gly Gly Val Pro Trp Arg Ala Arg Leu Asn Ser Ile 
        515                 520                 525             


Lys Asn Ser Phe Leu Gly Ser Pro Arg Phe His Arg Arg Lys Leu Gln 
    530                 535                 540                 


Val Pro Xaa Pro Glu Glu Met Ser Asn Leu Xaa Pro Glu Ser Ser Pro 
545                 550                 555                 560 


Glu Leu Ala Lys Lys Ser Trp Phe Gly Asn Phe Ile Ser Leu Glu Lys 
                565                 570                 575     


Glu Glu Gln Ile Phe Val Val Ile Lys Asp Lys Pro Leu Ser Ser Ile 
            580                 585                 590         


Lys Ala Asp Ile Val His Ala Phe Leu Ser Ile Pro Ser Leu Ser His 
        595                 600                 605             


Ser Val Ile Ser Gln Xaa Ser Phe Arg Ala Glu Tyr Lys Ala Xaa Gly 
    610                 615                 620                 


Gly Pro Ala Val Phe Gln Lys Pro Val Lys Phe Gln Val Asp Ile Xaa 
625                 630                 635                 640 


Tyr Xaa Glu Gly Gly Glu Ala Gln Lys Glu Asn Gly Ile Tyr Ser Val 
                645                 650                 655     


Xaa Phe Xaa Leu Leu Ser Gly Pro Ser Arg Arg Phe Lys Arg Val Val 
            660                 665                 670         


Glu Xaa Ile Gln Ala Gln Leu Leu Ser Xaa His Asp Pro Pro Ala Ala 
        675                 680                 685             


Gln His Leu Ser Asp Xaa Xaa Asn Cys Met Glu Met Met Xaa Gly Arg 
    690                 695                 700                 


Leu Ser Lys Cys Asp Glu Lys Asn Gly Gln Ala Ala Gln Ala Pro Ser 
705                 710                 715                 720 


Xaa Pro Ala Lys Arg Ser Ala His Gly Pro Leu Gly Asp Ser Ala Ala 
                725                 730                 735     


Ala Gly Pro Gly Pro Gly Gly Asp Ala Glu Tyr Pro Xaa Gly Lys Asp 
            740                 745                 750         


Xaa Ala Lys Met Gly Pro Pro Xaa Ala Arg Arg Glu Gln Pro 
        755                 760                 765     


<210> 4464
<211> 668
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<400> 4464
Met Xaa Ser Xaa Gly Lys Asp Gly Gly Ala Gln His Ala Gln Tyr Val 
1               5                   10                  15      


Gly Pro Tyr Arg Leu Glu Lys Xaa Leu Gly Lys Gly Gln Xaa Gly Leu 
            20                  25                  30          


Val Lys Leu Gly Val His Cys Val Xaa Cys Gln Lys Val Ala Ile Lys 
        35                  40                  45              


Ile Val Asn Arg Glu Lys Leu Ser Glu Ser Val Leu Met Lys Val Glu 
    50                  55                  60                  


Arg Glu Ile Ala Ile Leu Lys Leu Ile Glu His Pro His Val Leu Lys 
65                  70                  75                  80  


Leu His Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr Leu Val Leu Glu 
                85                  90                  95      


His Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val Lys Lys Gly Arg 
            100                 105                 110         


Leu Xaa Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln Ile Ile Ser Ala 
        115                 120                 125             


Leu Asp Phe Cys His Ser His Ser Ile Cys His Arg Asp Leu Lys Pro 
    130                 135                 140                 


Glu Asn Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg Ile Ala Asp Phe 
145                 150                 155                 160 


Gly Met Ala Ser Leu Gln Val Gly Asp Ser Leu Leu Glu Xaa Ser Cys 
                165                 170                 175     


Gly Ser Pro His Tyr Ala Cys Pro Glu Val Ile Arg Gly Glu Lys Tyr 
            180                 185                 190         


Asp Gly Arg Lys Ala Asp Val Trp Ser Cys Gly Val Ile Leu Phe Ala 
        195                 200                 205             


Leu Leu Val Gly Ala Leu Pro Phe Asp Asp Asp Asn Leu Arg Gln Leu 
    210                 215                 220                 


Leu Glu Lys Val Lys Arg Gly Val Phe His Met Pro His Phe Ile Pro 
225                 230                 235                 240 


Pro Asp Cys Gln Ser Leu Leu Arg Gly Met Ile Glu Val Asp Ala Ala 
                245                 250                 255     


Arg Arg Leu Xaa Leu Glu His Ile Gln Lys His Ile Trp Tyr Ile Gly 
            260                 265                 270         


Gly Lys Asn Glu Pro Glu Pro Glu Gln Pro Ile Pro Arg Lys Val Gln 
        275                 280                 285             


Ile Arg Ser Leu Pro Ser Leu Glu Asp Ile Asp Pro Asp Val Leu Asp 
    290                 295                 300                 


Ser Met His Ser Leu Gly Cys Phe Arg Asp Arg Asn Lys Leu Leu Gln 
305                 310                 315                 320 


Asp Leu Leu Ser Glu Glu Glu Asn Gln Glu Lys Met Ile Tyr Phe Leu 
                325                 330                 335     


Leu Leu Asp Arg Lys Glu Arg Tyr Pro Ser Gln Glu Asp Glu Asp Leu 
            340                 345                 350         


Pro Pro Arg Asn Glu Ile Asp Pro Pro Arg Lys Arg Val Asp Ser Pro 
        355                 360                 365             


Met Leu Asn Arg His Gly Lys Arg Arg Pro Glu Arg Lys Ser Met Glu 
    370                 375                 380                 


Val Leu Ser Val Xaa Asp Gly Gly Ser Pro Val Pro Ala Arg Arg Ala 
385                 390                 395                 400 


Ile Glu Met Ala Gln His Gly Gln Arg Ser Arg Ser Ile Ser Gly Ala 
                405                 410                 415     


Ser Ser Gly Leu Ser Xaa Ser Pro Leu Ser Ser Pro Arg Val Xaa Pro 
            420                 425                 430         


His Pro Ser Pro Arg Gly Ser Pro Leu Pro Xaa Pro Lys Gly Xaa Pro 
        435                 440                 445             


Val His Xaa Pro Lys Glu Ser Pro Ala Gly Xaa Pro Asn Pro Xaa Pro 
    450                 455                 460                 


Pro Ser Ser Pro Ser Val Gly Gly Val Pro Trp Arg Ala Arg Leu Asn 
465                 470                 475                 480 


Ser Ile Lys Asn Ser Phe Leu Gly Ser Pro Arg Phe His Arg Arg Lys 
                485                 490                 495     


Leu Gln Val Pro Xaa Pro Glu Glu Met Ser Asn Leu Xaa Pro Glu Ser 
            500                 505                 510         


Ser Pro Glu Leu Ala Lys Lys Ser Trp Phe Gly Asn Phe Ile Ser Leu 
        515                 520                 525             


Glu Lys Glu Glu Gln Ile Phe Val Val Ile Lys Asp Lys Pro Leu Ser 
    530                 535                 540                 


Ser Ile Lys Ala Asp Ile Val His Ala Phe Leu Ser Ile Pro Ser Leu 
545                 550                 555                 560 


Ser His Ser Val Ile Ser Gln Xaa Ser Phe Arg Ala Glu Tyr Lys Ala 
                565                 570                 575     


Xaa Gly Gly Pro Ala Val Phe Gln Lys Pro Val Lys Phe Gln Val Asp 
            580                 585                 590         


Ile Xaa Tyr Xaa Glu Gly Gly Glu Ala Gln Lys Glu Asn Gly Ile Tyr 
        595                 600                 605             


Ser Val Xaa Phe Xaa Leu Leu Ser Gly Pro Ser Arg Arg Phe Lys Arg 
    610                 615                 620                 


Val Val Glu Xaa Ile Gln Ala Gln Leu Leu Ser Xaa His Asp Pro Pro 
625                 630                 635                 640 


Ala Ala Gln His Leu Ser Asp Xaa Xaa Asn Cys Met Glu Met Met Xaa 
                645                 650                 655     


Gly Arg Leu Ser Lys Cys Gly Ile Ile Pro Lys Ser 
            660                 665             


<210> 4465
<211> 674
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<400> 4465
Met Xaa Ser Xaa Gly Lys Asp Gly Gly Ala Gln His Ala Gln Tyr Val 
1               5                   10                  15      


Gly Pro Tyr Arg Leu Glu Lys Xaa Leu Gly Lys Gly Gln Xaa Gly Leu 
            20                  25                  30          


Val Lys Leu Gly Val His Cys Val Xaa Cys Gln Lys Val Ala Ile Lys 
        35                  40                  45              


Ile Val Asn Arg Glu Lys Leu Ser Glu Ser Val Leu Met Lys Val Glu 
    50                  55                  60                  


Arg Glu Ile Ala Ile Leu Lys Leu Ile Glu His Pro His Val Leu Lys 
65                  70                  75                  80  


Leu His Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr Leu Val Leu Glu 
                85                  90                  95      


His Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val Lys Lys Gly Arg 
            100                 105                 110         


Leu Xaa Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln Ile Ile Ser Ala 
        115                 120                 125             


Leu Asp Phe Cys His Ser His Ser Ile Cys His Arg Asp Leu Lys Pro 
    130                 135                 140                 


Glu Asn Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg Ile Ala Asp Phe 
145                 150                 155                 160 


Gly Met Ala Ser Leu Gln Val Gly Asp Ser Leu Leu Glu Xaa Ser Cys 
                165                 170                 175     


Gly Ser Pro His Tyr Ala Cys Pro Glu Val Ile Arg Gly Glu Lys Tyr 
            180                 185                 190         


Asp Gly Arg Lys Ala Asp Val Trp Ser Cys Gly Val Ile Leu Phe Ala 
        195                 200                 205             


Leu Leu Val Gly Ala Leu Pro Phe Asp Asp Asp Asn Leu Arg Gln Leu 
    210                 215                 220                 


Leu Glu Lys Val Lys Arg Gly Val Phe His Met Pro His Phe Ile Pro 
225                 230                 235                 240 


Pro Asp Cys Gln Ser Leu Leu Arg Gly Met Ile Glu Val Asp Ala Ala 
                245                 250                 255     


Arg Arg Leu Xaa Leu Glu His Ile Gln Lys His Ile Trp Tyr Ile Gly 
            260                 265                 270         


Gly Lys Asn Glu Pro Glu Pro Glu Gln Pro Ile Pro Arg Lys Val Gln 
        275                 280                 285             


Ile Arg Ser Leu Pro Ser Leu Glu Asp Ile Asp Pro Asp Val Leu Asp 
    290                 295                 300                 


Ser Met His Ser Leu Gly Cys Phe Arg Asp Arg Asn Lys Leu Leu Gln 
305                 310                 315                 320 


Asp Leu Leu Ser Glu Glu Glu Asn Gln Glu Lys Met Ile Tyr Phe Leu 
                325                 330                 335     


Leu Leu Asp Arg Lys Glu Arg Tyr Pro Ser Gln Glu Asp Glu Asp Leu 
            340                 345                 350         


Pro Pro Arg Asn Glu Ile Asp Pro Pro Arg Lys Arg Val Asp Ser Pro 
        355                 360                 365             


Met Leu Asn Arg His Gly Lys Arg Arg Pro Glu Arg Lys Ser Met Glu 
    370                 375                 380                 


Val Leu Ser Val Xaa Asp Gly Gly Ser Pro Val Pro Ala Arg Arg Ala 
385                 390                 395                 400 


Ile Glu Met Ala Gln His Gly Gln Arg Ser Arg Ser Ile Ser Gly Ala 
                405                 410                 415     


Ser Ser Gly Leu Ser Xaa Ser Pro Leu Ser Ser Pro Arg Val Xaa Pro 
            420                 425                 430         


His Pro Ser Pro Arg Gly Ser Pro Leu Pro Xaa Pro Lys Gly Xaa Pro 
        435                 440                 445             


Val His Xaa Pro Lys Glu Ser Pro Ala Gly Xaa Pro Asn Pro Xaa Pro 
    450                 455                 460                 


Pro Ser Ser Pro Ser Val Gly Gly Val Pro Trp Arg Ala Arg Leu Asn 
465                 470                 475                 480 


Ser Ile Lys Asn Ser Phe Leu Gly Ser Pro Arg Phe His Arg Arg Lys 
                485                 490                 495     


Leu Gln Val Pro Xaa Pro Glu Glu Met Ser Asn Leu Xaa Pro Glu Ser 
            500                 505                 510         


Ser Pro Glu Leu Ala Lys Lys Ser Trp Phe Gly Asn Phe Ile Ser Leu 
        515                 520                 525             


Glu Lys Glu Glu Gln Ile Phe Val Val Ile Lys Asp Lys Pro Leu Ser 
    530                 535                 540                 


Ser Ile Lys Ala Asp Ile Val His Ala Phe Leu Ser Ile Pro Ser Leu 
545                 550                 555                 560 


Ser His Ser Val Ile Ser Gln Xaa Ser Phe Arg Ala Glu Tyr Lys Ala 
                565                 570                 575     


Xaa Gly Gly Pro Ala Val Phe Gln Lys Pro Val Lys Phe Gln Val Asp 
            580                 585                 590         


Ile Xaa Tyr Xaa Glu Gly Gly Glu Ala Gln Lys Glu Asn Gly Ile Tyr 
        595                 600                 605             


Ser Val Xaa Phe Xaa Leu Leu Ser Gly Pro Ser Arg Arg Phe Lys Arg 
    610                 615                 620                 


Val Val Glu Xaa Ile Gln Ala Gln Leu Leu Ser Xaa His Asp Pro Pro 
625                 630                 635                 640 


Ala Ala Gln His Leu Ser Glu Pro Pro Pro Pro Ala Pro Gly Leu Ser 
                645                 650                 655     


Trp Gly Ala Gly Leu Lys Gly Gln Lys Val Ala Xaa Ser Tyr Glu Ser 
            660                 665                 670         


Ser Leu 
        


<210> 4466
<211> 696
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<400> 4466
Met Xaa Ser Xaa Gly Lys Asp Gly Gly Ala Gln His Ala Gln Tyr Val 
1               5                   10                  15      


Gly Pro Tyr Arg Leu Glu Lys Xaa Leu Gly Lys Gly Gln Xaa Gly Leu 
            20                  25                  30          


Val Lys Leu Gly Val His Cys Val Xaa Cys Gln Lys Val Ala Ile Lys 
        35                  40                  45              


Ile Val Asn Arg Glu Lys Leu Ser Glu Ser Val Leu Met Lys Val Glu 
    50                  55                  60                  


Arg Glu Ile Ala Ile Leu Lys Leu Ile Glu His Pro His Val Leu Lys 
65                  70                  75                  80  


Leu His Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr Leu Val Leu Glu 
                85                  90                  95      


His Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val Lys Lys Gly Arg 
            100                 105                 110         


Leu Xaa Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln Ile Ile Ser Ala 
        115                 120                 125             


Leu Asp Phe Cys His Ser His Ser Ile Cys His Arg Asp Leu Lys Pro 
    130                 135                 140                 


Glu Asn Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg Ile Ala Asp Phe 
145                 150                 155                 160 


Gly Met Ala Ser Leu Gln Val Gly Asp Ser Leu Leu Glu Xaa Ser Cys 
                165                 170                 175     


Gly Ser Pro His Tyr Ala Cys Pro Glu Val Ile Arg Gly Glu Lys Tyr 
            180                 185                 190         


Asp Gly Arg Lys Ala Asp Val Trp Ser Cys Gly Val Ile Leu Phe Ala 
        195                 200                 205             


Leu Leu Val Gly Ala Leu Pro Phe Asp Asp Asp Asn Leu Arg Gln Leu 
    210                 215                 220                 


Leu Glu Lys Val Lys Arg Gly Val Phe His Met Pro His Phe Ile Pro 
225                 230                 235                 240 


Pro Asp Cys Gln Ser Leu Leu Arg Gly Met Ile Glu Val Asp Ala Ala 
                245                 250                 255     


Arg Arg Leu Xaa Leu Glu His Ile Gln Lys His Ile Trp Tyr Ile Gly 
            260                 265                 270         


Gly Lys Asn Glu Pro Glu Pro Glu Gln Pro Ile Pro Arg Lys Val Gln 
        275                 280                 285             


Ile Arg Ser Leu Pro Ser Leu Glu Asp Ile Asp Pro Asp Val Leu Asp 
    290                 295                 300                 


Ser Met His Ser Leu Gly Cys Phe Arg Asp Arg Asn Lys Leu Leu Gln 
305                 310                 315                 320 


Asp Leu Leu Ser Glu Glu Glu Asn Gln Glu Lys Met Ile Tyr Phe Leu 
                325                 330                 335     


Leu Leu Asp Arg Lys Glu Arg Tyr Pro Ser Gln Glu Asp Glu Asp Leu 
            340                 345                 350         


Pro Pro Arg Asn Glu Ile Asp Pro Pro Arg Lys Arg Val Asp Ser Pro 
        355                 360                 365             


Met Leu Asn Arg His Gly Lys Arg Arg Pro Glu Arg Lys Ser Met Glu 
    370                 375                 380                 


Val Leu Ser Val Xaa Asp Gly Gly Ser Pro Val Pro Ala Arg Arg Ala 
385                 390                 395                 400 


Ile Glu Met Ala Gln His Gly Gln Ser Lys Ala Met Phe Ser Lys Ser 
                405                 410                 415     


Leu Asp Ile Ala Glu Ala His Pro Gln Phe Ser Lys Glu Asp Arg Ser 
            420                 425                 430         


Arg Ser Ile Ser Gly Ala Ser Ser Gly Leu Ser Xaa Ser Pro Leu Ser 
        435                 440                 445             


Ser Pro Arg Val Xaa Pro His Pro Ser Pro Arg Gly Ser Pro Leu Pro 
    450                 455                 460                 


Xaa Pro Lys Gly Xaa Pro Val His Xaa Pro Lys Glu Ser Pro Ala Gly 
465                 470                 475                 480 


Xaa Pro Asn Pro Xaa Pro Pro Ser Ser Pro Ser Val Gly Gly Val Pro 
                485                 490                 495     


Trp Arg Ala Arg Leu Asn Ser Ile Lys Asn Ser Phe Leu Gly Ser Pro 
            500                 505                 510         


Arg Phe His Arg Arg Lys Leu Gln Val Pro Xaa Pro Glu Glu Met Ser 
        515                 520                 525             


Asn Leu Xaa Pro Glu Ser Ser Pro Glu Leu Ala Lys Lys Ser Trp Phe 
    530                 535                 540                 


Gly Asn Phe Ile Ser Leu Glu Lys Glu Glu Gln Ile Phe Val Val Ile 
545                 550                 555                 560 


Lys Asp Lys Pro Leu Ser Ser Ile Lys Ala Asp Ile Val His Ala Phe 
                565                 570                 575     


Leu Ser Ile Pro Ser Leu Ser His Ser Val Ile Ser Gln Xaa Ser Phe 
            580                 585                 590         


Arg Ala Glu Tyr Lys Ala Xaa Gly Gly Pro Ala Val Phe Gln Lys Pro 
        595                 600                 605             


Val Lys Phe Gln Val Asp Ile Xaa Tyr Xaa Glu Gly Gly Glu Ala Gln 
    610                 615                 620                 


Lys Glu Asn Gly Ile Tyr Ser Val Xaa Phe Xaa Leu Leu Ser Gly Pro 
625                 630                 635                 640 


Ser Arg Arg Phe Lys Arg Val Val Glu Xaa Ile Gln Ala Gln Leu Leu 
                645                 650                 655     


Ser Xaa His Asp Pro Pro Ala Ala Gln His Leu Ser Glu Pro Pro Pro 
            660                 665                 670         


Pro Ala Pro Gly Leu Ser Trp Gly Ala Gly Leu Lys Gly Gln Lys Val 
        675                 680                 685             


Ala Xaa Ser Tyr Glu Ser Ser Leu 
    690                 695     


<210> 4467
<211> 736
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<400> 4467
Met Xaa Ser Xaa Gly Lys Asp Gly Gly Ala Gln His Ala Gln Tyr Val 
1               5                   10                  15      


Gly Pro Tyr Arg Leu Glu Lys Xaa Leu Gly Lys Gly Gln Xaa Gly Leu 
            20                  25                  30          


Val Lys Leu Gly Val His Cys Val Xaa Cys Gln Lys Val Ala Ile Lys 
        35                  40                  45              


Ile Val Asn Arg Glu Lys Leu Ser Glu Ser Val Leu Met Lys Val Glu 
    50                  55                  60                  


Arg Glu Ile Ala Ile Leu Lys Leu Ile Glu His Pro His Val Leu Lys 
65                  70                  75                  80  


Leu His Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr Leu Val Leu Glu 
                85                  90                  95      


His Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val Lys Lys Gly Arg 
            100                 105                 110         


Leu Xaa Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln Ile Ile Ser Ala 
        115                 120                 125             


Leu Asp Phe Cys His Ser His Ser Ile Cys His Arg Asp Leu Lys Pro 
    130                 135                 140                 


Glu Asn Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg Ile Ala Asp Phe 
145                 150                 155                 160 


Gly Met Ala Ser Leu Gln Val Gly Asp Ser Leu Leu Glu Xaa Ser Cys 
                165                 170                 175     


Gly Ser Pro His Tyr Ala Cys Pro Glu Val Ile Arg Gly Glu Lys Tyr 
            180                 185                 190         


Asp Gly Arg Lys Ala Asp Val Trp Ser Cys Gly Val Ile Leu Phe Ala 
        195                 200                 205             


Leu Leu Val Gly Ala Leu Pro Phe Asp Asp Asp Asn Leu Arg Gln Leu 
    210                 215                 220                 


Leu Glu Lys Val Lys Arg Gly Val Phe His Met Pro His Phe Ile Pro 
225                 230                 235                 240 


Pro Asp Cys Gln Ser Leu Leu Arg Gly Met Ile Glu Val Asp Ala Ala 
                245                 250                 255     


Arg Arg Leu Xaa Leu Glu His Ile Gln Lys His Ile Trp Tyr Ile Gly 
            260                 265                 270         


Gly Lys Asn Glu Pro Glu Pro Glu Gln Pro Ile Pro Arg Lys Val Gln 
        275                 280                 285             


Ile Arg Ser Leu Pro Ser Leu Glu Asp Ile Asp Pro Asp Val Leu Asp 
    290                 295                 300                 


Ser Met His Ser Leu Gly Cys Phe Arg Asp Arg Asn Lys Leu Leu Gln 
305                 310                 315                 320 


Asp Leu Leu Ser Glu Glu Glu Asn Gln Glu Lys Met Ile Tyr Phe Leu 
                325                 330                 335     


Leu Leu Asp Arg Lys Glu Arg Tyr Pro Ser Gln Glu Asp Glu Asp Leu 
            340                 345                 350         


Pro Pro Arg Asn Glu Ile Asp Pro Pro Arg Lys Arg Val Asp Ser Pro 
        355                 360                 365             


Met Leu Asn Arg His Gly Lys Arg Arg Pro Glu Arg Lys Ser Met Glu 
    370                 375                 380                 


Val Leu Ser Val Xaa Asp Gly Gly Ser Pro Val Pro Ala Arg Arg Ala 
385                 390                 395                 400 


Ile Glu Met Ala Gln His Gly Gln Arg Ser Arg Ser Ile Ser Gly Ala 
                405                 410                 415     


Ser Ser Gly Leu Ser Xaa Ser Pro Leu Ser Ser Pro Arg Val Xaa Pro 
            420                 425                 430         


His Pro Ser Pro Arg Gly Ser Pro Leu Pro Xaa Pro Lys Gly Xaa Pro 
        435                 440                 445             


Val His Xaa Pro Lys Glu Ser Pro Ala Gly Xaa Pro Asn Pro Xaa Pro 
    450                 455                 460                 


Pro Ser Ser Pro Ser Val Gly Gly Val Pro Trp Arg Ala Arg Leu Asn 
465                 470                 475                 480 


Ser Ile Lys Asn Ser Phe Leu Gly Ser Pro Arg Phe His Arg Arg Lys 
                485                 490                 495     


Leu Gln Val Pro Xaa Pro Glu Glu Met Ser Asn Leu Xaa Pro Glu Ser 
            500                 505                 510         


Ser Pro Glu Leu Ala Lys Lys Ser Trp Phe Gly Asn Phe Ile Ser Leu 
        515                 520                 525             


Glu Lys Glu Glu Gln Ile Phe Val Val Ile Lys Asp Lys Pro Leu Ser 
    530                 535                 540                 


Ser Ile Lys Ala Asp Ile Val His Ala Phe Leu Ser Ile Pro Ser Leu 
545                 550                 555                 560 


Ser His Ser Val Ile Ser Gln Xaa Ser Phe Arg Ala Glu Tyr Lys Ala 
                565                 570                 575     


Xaa Gly Gly Pro Ala Val Phe Gln Lys Pro Val Lys Phe Gln Val Asp 
            580                 585                 590         


Ile Xaa Tyr Xaa Glu Gly Gly Glu Ala Gln Lys Glu Asn Gly Ile Tyr 
        595                 600                 605             


Ser Val Xaa Phe Xaa Leu Leu Ser Gly Pro Ser Arg Arg Phe Lys Arg 
    610                 615                 620                 


Val Val Glu Xaa Ile Gln Ala Gln Leu Leu Ser Xaa His Asp Pro Pro 
625                 630                 635                 640 


Ala Ala Gln His Leu Ser Asp Xaa Xaa Asn Cys Met Glu Met Met Xaa 
                645                 650                 655     


Gly Arg Leu Ser Lys Cys Gly Ser Pro Leu Ser Asn Phe Phe Asp Val 
            660                 665                 670         


Ile Lys Gln Leu Phe Ser Asp Glu Lys Asn Gly Gln Ala Ala Gln Ala 
        675                 680                 685             


Pro Ser Xaa Pro Ala Lys Arg Ser Ala His Gly Pro Leu Gly Asp Ser 
    690                 695                 700                 


Ala Ala Ala Gly Pro Gly Pro Gly Gly Asp Ala Glu Tyr Pro Xaa Gly 
705                 710                 715                 720 


Lys Asp Xaa Ala Lys Met Gly Pro Pro Xaa Ala Arg Arg Glu Gln Pro 
                725                 730                 735     


<210> 4468
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 4468
Xaa Glu His Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val Lys Lys 
1               5                   10                  15      


Gly Arg Leu Xaa Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln Ile Ile 
            20                  25                  30          


Ser Ala Leu Asp Phe Cys His Ser His Ser Ile Cys His Arg Asp Leu 
        35                  40                  45              


Lys Pro Glu Asn Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg Ile Ala 
    50                  55                  60                  


Asp Phe Gly Met Ala Ser Leu Gln Val Gly Asp Ser Leu Leu Glu Xaa 
65                  70                  75                  80  


Ser Cys Gly Ser Pro His Tyr Ala Cys Pro Glu Val Ile Arg Gly Glu 
                85                  90                  95      


Lys Tyr Asp Gly Arg Lys Ala Asp Val Trp Ser Cys Gly Val Ile Leu 
            100                 105                 110         


Phe Ala Leu Leu Val Gly Ala Leu Pro Phe Asp Asp Asp Asn Leu Arg 
        115                 120                 125             


Gln Leu Leu Glu Lys Val Lys Arg Gly Val Phe His Met Pro His Phe 
    130                 135                 140                 


Ile Pro Pro Asp Cys Gln Ser Leu Leu Arg Gly Met Ile Glu Val Asp 
145                 150                 155                 160 


Ala Ala Arg Arg Leu Xaa Arg Gly Gln Glu 
                165                 170 


<210> 4469
<211> 200
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<400> 4469
Xaa Xaa Pro Pro Ser Ser Pro Ser Val Gly Gly Val Pro Trp Arg Ala 
1               5                   10                  15      


Arg Leu Asn Ser Ile Lys Asn Ser Phe Leu Gly Ser Pro Arg Phe His 
            20                  25                  30          


Arg Arg Lys Leu Gln Val Pro Xaa Pro Glu Glu Met Ser Asn Leu Xaa 
        35                  40                  45              


Pro Glu Ser Ser Pro Glu Leu Ala Lys Lys Ser Trp Phe Gly Asn Phe 
    50                  55                  60                  


Ile Ser Leu Glu Lys Glu Glu Gln Ile Phe Val Val Ile Lys Asp Lys 
65                  70                  75                  80  


Pro Leu Ser Ser Ile Lys Ala Asp Ile Val His Ala Phe Leu Ser Ile 
                85                  90                  95      


Pro Ser Leu Ser His Ser Val Ile Ser Gln Xaa Ser Phe Arg Ala Glu 
            100                 105                 110         


Tyr Lys Ala Xaa Gly Gly Pro Ala Val Phe Gln Lys Pro Val Lys Phe 
        115                 120                 125             


Gln Val Asp Ile Xaa Tyr Xaa Glu Gly Gly Glu Ala Gln Lys Glu Asn 
    130                 135                 140                 


Gly Ile Tyr Ser Val Xaa Phe Xaa Leu Leu Ser Gly Pro Ser Arg Arg 
145                 150                 155                 160 


Phe Lys Arg Val Val Glu Xaa Ile Gln Ala Gln Leu Leu Ser Xaa His 
                165                 170                 175     


Asp Pro Pro Ala Ala Gln His Leu Ser Asp Xaa Xaa Asn Cys Met Glu 
            180                 185                 190         


Met Met Xaa Gly Arg Leu Ser Lys 
        195                 200 


<210> 4470
<211> 385
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<400> 4470
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Xaa 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Phe Val Gln Ala Pro Leu Ser Gln 
            20                  25                  30          


Gln Arg Trp Val Gly Gly Ser Val Glu Leu His Cys Glu Ala Val Gly 
        35                  40                  45              


Ser Pro Val Pro Glu Ile Gln Trp Trp Phe Glu Gly Gln Gly Pro Asn 
    50                  55                  60                  


Asp Xaa Cys Ser Gln Leu Trp Asp Gly Ala Arg Leu Asp Arg Val His 
65                  70                  75                  80  


Ile His Ala Xaa Tyr His Gln His Ala Ala Ser Xaa Ile Ser Ile Asp 
                85                  90                  95      


Xaa Leu Val Glu Glu Asp Xaa Gly Xaa Tyr Glu Cys Arg Ala Ser Asn 
            100                 105                 110         


Asp Pro Asp Arg Asn His Leu Xaa Arg Ala Pro Arg Val Lys Trp Val 
        115                 120                 125             


Arg Ala Gln Ala Val Val Leu Val Leu Glu Pro Gly Xaa Val Phe Xaa 
    130                 135                 140                 


Xaa Val Glu Asp Leu Gly Ser Lys Ile Leu Leu Xaa Cys Ser Leu Asn 
145                 150                 155                 160 


Asp Ser Ala Xaa Glu Val Xaa Gly His Arg Trp Leu Lys Gly Gly Val 
                165                 170                 175     


Val Leu Lys Glu Asp Ala Leu Pro Gly Gln Lys Xaa Glu Phe Lys Val 
            180                 185                 190         


Asp Ser Asp Asp Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu 
        195                 200                 205             


Pro Met Gly Xaa Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys 
    210                 215                 220                 


Ala Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Xaa Ala Met Leu 
225                 230                 235                 240 


Val Cys Lys Ser Glu Ser Val Pro Pro Val Xaa Asp Trp Ala Trp Tyr 
                245                 250                 255     


Lys Ile Xaa Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser 
            260                 265                 270         


Arg Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu 
        275                 280                 285             


Asn Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Xaa 
    290                 295                 300                 


Ser Ser Lys Gly Ser Asp Gln Ala Ile Ile Xaa Leu Arg Val Arg Ser 
305                 310                 315                 320 


His Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu 
                325                 330                 335     


Val Leu Val Xaa Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu 
            340                 345                 350         


Asp Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser 
        355                 360                 365             


Gly Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser 
    370                 375                 380                 


Ser 
385 


<210> 4471
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<400> 4471
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Xaa 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Xaa Val Phe Xaa Xaa Val Glu Asp 
            20                  25                  30          


Leu Gly Ser Lys Ile Leu Leu Xaa Cys Ser Leu Asn Asp Ser Ala Xaa 
        35                  40                  45              


Glu Gln Arg Ala Ala Pro Glu 
    50                  55  


<210> 4472
<211> 269
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<400> 4472
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Xaa 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Xaa Val Phe Xaa Xaa Val Glu Asp 
            20                  25                  30          


Leu Gly Ser Lys Ile Leu Leu Xaa Cys Ser Leu Asn Asp Ser Ala Xaa 
        35                  40                  45              


Glu Val Xaa Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu 
    50                  55                  60                  


Asp Ala Leu Pro Gly Gln Lys Xaa Glu Phe Lys Val Asp Ser Asp Asp 
65                  70                  75                  80  


Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Xaa 
                85                  90                  95      


Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser 
            100                 105                 110         


Ser Glu His Ile Asn Glu Gly Glu Xaa Ala Met Leu Val Cys Lys Ser 
        115                 120                 125             


Glu Ser Val Pro Pro Val Xaa Asp Trp Ala Trp Tyr Lys Ile Xaa Asp 
    130                 135                 140                 


Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val 
145                 150                 155                 160 


Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met 
                165                 170                 175     


Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Xaa Ser Ser Lys Gly 
            180                 185                 190         


Ser Asp Gln Ala Ile Ile Xaa Leu Arg Val Arg Ser His Leu Ala Ala 
        195                 200                 205             


Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Xaa 
    210                 215                 220                 


Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp 
225                 230                 235                 240 


Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln 
                245                 250                 255     


Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
            260                 265                 


<210> 4473
<211> 161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<400> 4473
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Xaa 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Glu Asp Leu Gly Ser Lys Ile Leu Leu Xaa 
            20                  25                  30          


Cys Ser Leu Asn Asp Ser Ala Xaa Glu Val Xaa Gly His Arg Trp Leu 
        35                  40                  45              


Lys Gly Gly Val Val Leu Lys Glu Asp Ala Leu Pro Gly Gln Lys Xaa 
    50                  55                  60                  


Glu Phe Lys Val Asp Ser Asp Asp Gln Trp Gly Glu Tyr Ser Cys Val 
65                  70                  75                  80  


Phe Leu Pro Glu Pro Met Gly Xaa Ala Asn Ile Gln Leu His Gly Pro 
                85                  90                  95      


Pro Arg Val Lys Ala Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu 
            100                 105                 110         


Xaa Ala Met Leu Val Cys Lys Ser Glu Ser Val Pro Pro Val Xaa Asp 
        115                 120                 125             


Trp Ala Trp Tyr Lys Ile Xaa Asp Ser Glu Asp Lys Ala Leu Met Asn 
    130                 135                 140                 


Gly Ser Glu Ser Arg Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu 
145                 150                 155                 160 


Leu 
    


<210> 4474
<211> 189
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<400> 4474
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Xaa 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Gly Pro Pro Arg Val Lys Ala Val Lys Ser 
            20                  25                  30          


Ser Glu His Ile Asn Glu Gly Glu Xaa Ala Met Leu Val Cys Lys Ser 
        35                  40                  45              


Glu Ser Val Pro Pro Val Xaa Asp Trp Ala Trp Tyr Lys Ile Xaa Asp 
    50                  55                  60                  


Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val 
65                  70                  75                  80  


Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met 
                85                  90                  95      


Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Xaa Ser Ser Lys Gly 
            100                 105                 110         


Ser Asp Gln Ala Ile Ile Xaa Leu Arg Val Arg Ser His Leu Ala Ala 
        115                 120                 125             


Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Xaa 
    130                 135                 140                 


Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp 
145                 150                 155                 160 


Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln 
                165                 170                 175     


Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
            180                 185                 


<210> 4475
<211> 221
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<400> 4475
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Xaa 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Val Phe Xaa Xaa Val Glu Asp Leu Gly Ser 
            20                  25                  30          


Lys Ile Leu Leu Xaa Cys Ser Leu Asn Asp Ser Ala Xaa Glu Val Xaa 
        35                  40                  45              


Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu Asp Ala Leu 
    50                  55                  60                  


Pro Gly Gln Lys Xaa Glu Phe Lys Val Asp Ser Asp Asp Gln Trp Gly 
65                  70                  75                  80  


Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Xaa Ala Asn Ile 
                85                  90                  95      


Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser Ser Glu His 
            100                 105                 110         


Ile Asn Glu Gly Glu Xaa Ala Met Leu Val Cys Lys Ser Glu Ser Val 
        115                 120                 125             


Pro Pro Val Xaa Asp Trp Ala Trp Tyr Lys Ile Xaa Asp Ser Glu Asp 
    130                 135                 140                 


Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val Ser Ser Ser 
145                 150                 155                 160 


Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met Glu Ala Asp 
                165                 170                 175     


Pro Gly Gln Tyr Arg Cys Asn Gly Xaa Ser Ser Lys Gly Ser Asp Gln 
            180                 185                 190         


Ala Ile Ile Xaa Leu Arg Val Arg Ser His Leu Ala Ala Leu Trp Pro 
        195                 200                 205             


Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Xaa 
    210                 215                 220     


<210> 4476
<211> 52
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 4476
Met Gly Xaa Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala 
1               5                   10                  15      


Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Xaa Ala Met Leu Val 
            20                  25                  30          


Cys Lys Ser Glu Ser Val Pro Pro Val Xaa Asp Trp Ala Trp Tyr Lys 
        35                  40                  45              


Ile Xaa Asp Ser 
    50          


<210> 4477
<211> 84
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 4477
Met Gly Xaa Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala 
1               5                   10                  15      


Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Xaa Ala Met Leu Val 
            20                  25                  30          


Cys Lys Ser Glu Ser Val Pro Pro Val Xaa Asp Trp Ala Trp Tyr Lys 
        35                  40                  45              


Ile Xaa Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg 
    50                  55                  60                  


Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn 
65                  70                  75                  80  


Leu Asn Met Glu 
                


<210> 4478
<211> 176
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<400> 4478
Met Gly Xaa Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala 
1               5                   10                  15      


Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Xaa Ala Met Leu Val 
            20                  25                  30          


Cys Lys Ser Glu Ser Val Pro Pro Val Xaa Asp Trp Ala Trp Tyr Lys 
        35                  40                  45              


Ile Xaa Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg 
    50                  55                  60                  


Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn 
65                  70                  75                  80  


Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Xaa Ser 
                85                  90                  95      


Ser Lys Gly Ser Asp Gln Ala Ile Ile Xaa Leu Arg Val Arg Ser His 
            100                 105                 110         


Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val 
        115                 120                 125             


Leu Val Xaa Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp 
    130                 135                 140                 


Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly 
145                 150                 155                 160 


Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
                165                 170                 175     


<210> 4479
<211> 205
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<400> 4479
Met Lys Gln Ser Asp Ala Ser Pro Gln Glu Arg Val Asp Ser Asp Asp 
1               5                   10                  15      


Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Xaa 
            20                  25                  30          


Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser 
        35                  40                  45              


Ser Glu His Ile Asn Glu Gly Glu Xaa Ala Met Leu Val Cys Lys Ser 
    50                  55                  60                  


Glu Ser Val Pro Pro Val Xaa Asp Trp Ala Trp Tyr Lys Ile Xaa Asp 
65                  70                  75                  80  


Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val 
                85                  90                  95      


Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met 
            100                 105                 110         


Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Xaa Ser Ser Lys Gly 
        115                 120                 125             


Ser Asp Gln Ala Ile Ile Xaa Leu Arg Val Arg Ser His Leu Ala Ala 
    130                 135                 140                 


Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Xaa 
145                 150                 155                 160 


Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp 
                165                 170                 175     


Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln 
            180                 185                 190         


Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
        195                 200                 205 


<210> 4480
<211> 180
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(122)
<223> Selenocysteine

<400> 4480
Met Ala Ser Xaa Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly 
1               5                   10                  15      


Asp Lys Arg Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu 
            20                  25                  30          


Ile Ile Val Ile Leu Gly Val Pro Leu Ile Ile Phe Xaa Ile Lys Ala 
        35                  40                  45              


Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg 
    50                  55                  60                  


Asn Val Xaa His Leu Leu Gln Gln Glu Leu Xaa Glu Ala Gln Lys Gly 
65                  70                  75                  80  


Phe Gln Asp Val Glu Ala Gln Ala Ala Xaa Cys Asn His Xaa Val Met 
                85                  90                  95      


Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys 
            100                 105                 110         


Val Glu Glu Leu Glu Gly Glu Ile Xaa Xaa Leu Asn His Lys Leu Gln 
        115                 120                 125             


Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu 
    130                 135                 140                 


Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser 
145                 150                 155                 160 


Ser Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser 
                165                 170                 175     


Ala Leu Leu Gln 
            180 


<210> 4481
<211> 233
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<400> 4481
Met Asn Leu Asn Phe Xaa Ser Pro Leu His Pro Ala Ser Ser Gln Arg 
1               5                   10                  15      


Pro Xaa Ser Phe Phe Ile Glu Asp Ile Leu Leu His Lys Pro Lys Pro 
            20                  25                  30          


Leu Arg Glu Val Ala Pro Asp His Phe Ala Ser Ser Leu Ala Ser Arg 
        35                  40                  45              


Val Pro Leu Leu Asp Tyr Gly Tyr Pro Leu Met Pro Xaa Pro Xaa Leu 
    50                  55                  60                  


Leu Ala Pro His Ala His His Pro Leu His Lys Gly Asp His His His 
65                  70                  75                  80  


Pro Tyr Phe Leu Xaa Xaa Ser Gly Met Pro Val Pro Ala Leu Phe Pro 
                85                  90                  95      


His Pro Gln His Ala Glu Leu Pro Gly Lys His Cys Arg Arg Arg Lys 
            100                 105                 110         


Ala Arg Xaa Val Phe Ser Asp Ser Gln Leu Ser Gly Leu Glu Lys Arg 
        115                 120                 125             


Phe Glu Ile Gln Arg Tyr Leu Ser Xaa Pro Glu Arg Val Glu Leu Ala 
    130                 135                 140                 


Xaa Ala Leu Ser Leu Ser Glu Xaa Gln Val Lys Xaa Trp Phe Gln Asn 
145                 150                 155                 160 


Arg Arg Met Lys His Lys Lys Gln Leu Arg Lys Ser Gln Asp Glu Pro 
                165                 170                 175     


Lys Ala Pro Asp Gly Pro Glu Ser Pro Glu Gly Ser Pro Arg Gly Ser 
            180                 185                 190         


Glu Ala Ala Xaa Ala Ala Glu Ala Arg Leu Ser Leu Pro Ala Gly Pro 
        195                 200                 205             


Phe Val Leu Xaa Glu Pro Glu Asp Glu Val Asp Ile Gly Asp Glu Gly 
    210                 215                 220                 


Glu Leu Gly Ser Gly Pro His Val Leu 
225                 230             


<210> 4482
<211> 1849
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1091)..(1091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1120)..(1120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1138)..(1138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1298)..(1298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1338)..(1338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1360)..(1360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1364)..(1364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1424)..(1424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1523)..(1523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1552)..(1552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1557)..(1557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1565)..(1565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1587)..(1587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1595)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1638)..(1638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1673)..(1673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1705)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1716)..(1716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1720)..(1720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1756)..(1756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1759)..(1759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1777)..(1777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1791)..(1791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1799)..(1799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1811)..(1811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1813)..(1813)
<223> Selenocysteine

<400> 4482
Met Ala Val Ser Arg Leu Asp Arg Leu Phe Ile Leu Leu Asp Xaa Gly 
1               5                   10                  15      


Xaa Xaa Pro Val Xaa Arg Lys Ala Ala Ala Gln Gln Leu Gly Glu Val 
            20                  25                  30          


Val Lys Leu His Pro His Glu Leu Asn Asn Leu Leu Ser Lys Val Leu 
        35                  40                  45              


Ile Tyr Leu Arg Ser Ala Asn Trp Asp Xaa Arg Ile Ala Ala Gly Gln 
    50                  55                  60                  


Ala Val Glu Ala Ile Val Lys Asn Val Pro Glu Trp Asn Pro Val Pro 
65                  70                  75                  80  


Arg Xaa Arg Gln Glu Pro Xaa Ser Glu Ser Ser Met Glu Asp Ser Pro 
                85                  90                  95      


Xaa Xaa Glu Arg Leu Asn Phe Asp Arg Phe Asp Ile Cys Arg Leu Leu 
            100                 105                 110         


Gln His Gly Ala Ser Leu Leu Gly Ser Ala Gly Ala Glu Phe Glu Val 
        115                 120                 125             


Gln Asp Glu Lys Ser Gly Glu Val Asp Pro Lys Glu Arg Ile Ala Arg 
    130                 135                 140                 


Gln Arg Lys Leu Leu Gln Lys Lys Leu Gly Leu Asn Met Gly Glu Ala 
145                 150                 155                 160 


Ile Gly Met Ser Xaa Glu Glu Leu Phe Asn Asp Glu Asp Leu Asp Tyr 
                165                 170                 175     


Xaa Pro Xaa Ser Ala Ser Phe Val Asn Lys Gln Pro Xaa Leu Gln Ala 
            180                 185                 190         


Ala Glu Leu Ile Asp Ser Glu Phe Arg Ala Gly Met Ser Asn Arg Gln 
        195                 200                 205             


Lys Asn Lys Ala Lys Arg Met Ala Lys Leu Phe Ala Lys Gln Arg Ser 
    210                 215                 220                 


Arg Asp Ala Val Glu Xaa Asn Glu Lys Ser Asn Asp Ser Xaa Asp Gly 
225                 230                 235                 240 


Glu Pro Glu Glu Lys Arg Arg Lys Ile Ala Asn Val Val Ile Asn Gln 
                245                 250                 255     


Ser Ala Asn Asp Ser Lys Val Leu Ile Asp Asn Ile Pro Asp Ser Ser 
            260                 265                 270         


Ser Leu Ile Glu Glu Xaa Asn Glu Trp Pro Leu Glu Ser Phe Cys Glu 
        275                 280                 285             


Glu Leu Cys Asn Asp Leu Phe Asn Pro Ser Trp Glu Val Arg His Gly 
    290                 295                 300                 


Ala Gly Xaa Gly Leu Arg Glu Ile Leu Lys Ala His Gly Lys Ser Gly 
305                 310                 315                 320 


Gly Lys Met Gly Asp Ser Xaa Leu Glu Glu Met Ile Gln Gln His Gln 
                325                 330                 335     


Glu Trp Leu Glu Asp Leu Val Ile Arg Leu Leu Cys Val Phe Ala Leu 
            340                 345                 350         


Asp Arg Phe Gly Asp Phe Val Ser Asp Glu Val Val Ala Pro Val Arg 
        355                 360                 365             


Glu Xaa Cys Ala Gln Xaa Leu Gly Val Val Leu Lys His Met Asn Glu 
    370                 375                 380                 


Xaa Gly Val His Lys Xaa Val Asp Val Leu Leu Lys Leu Leu Xaa Gln 
385                 390                 395                 400 


Glu Gln Trp Glu Val Arg His Gly Gly Leu Leu Gly Ile Lys Tyr Ala 
                405                 410                 415     


Leu Ala Val Arg Gln Asp Val Ile Asn Xaa Leu Leu Pro Lys Val Leu 
            420                 425                 430         


Xaa Arg Ile Ile Glu Gly Leu Gln Asp Leu Asp Asp Asp Val Arg Ala 
        435                 440                 445             


Val Ala Ala Ala Ser Leu Val Pro Val Val Glu Ser Leu Val Tyr Leu 
    450                 455                 460                 


Gln Xaa Gln Lys Val Pro Phe Ile Ile Asn Xaa Leu Trp Asp Ala Leu 
465                 470                 475                 480 


Leu Glu Leu Asp Asp Leu Xaa Ala Ser Xaa Asn Ser Ile Met Xaa Leu 
                485                 490                 495     


Leu Ser Ser Leu Leu Xaa Tyr Pro Gln Val Gln Gln Cys Ser Ile Gln 
            500                 505                 510         


Gln Ser Leu Xaa Val Leu Val Pro Arg Val Trp Pro Phe Leu His His 
        515                 520                 525             


Xaa Ile Ser Ser Val Arg Arg Ala Ala Leu Glu Xaa Leu Phe Xaa Leu 
    530                 535                 540                 


Leu Ser Xaa Gln Asp Gln Asn Ser Ser Ser Trp Leu Ile Pro Ile Leu 
545                 550                 555                 560 


Pro Asp Met Leu Arg His Ile Phe Gln Phe Cys Val Leu Glu Ser Ser 
                565                 570                 575     


Gln Glu Ile Leu Asp Leu Ile His Lys Val Trp Met Glu Leu Leu Ser 
            580                 585                 590         


Lys Ala Ser Val Gln Tyr Val Val Ala Ala Ala Cys Pro Trp Met Gly 
        595                 600                 605             


Ala Trp Leu Cys Leu Met Met Gln Pro Ser His Leu Pro Ile Asp Leu 
    610                 615                 620                 


Asn Met Leu Leu Glu Val Lys Ala Arg Ala Lys Glu Lys Xaa Gly Gly 
625                 630                 635                 640 


Lys Val Arg Gln Gly Gln Ser Gln Asn Lys Glu Val Leu Gln Glu Tyr 
                645                 650                 655     


Ile Ala Gly Ala Asp Xaa Ile Met Glu Asp Pro Ala Xaa Arg Asp Phe 
            660                 665                 670         


Val Val Met Arg Ala Arg Met Met Ala Ala Lys Leu Leu Gly Ala Leu 
        675                 680                 685             


Cys Cys Cys Ile Cys Asp Pro Gly Val Asn Val Val Xaa Gln Glu Ile 
    690                 695                 700                 


Lys Pro Ala Glu Ser Leu Gly Gln Leu Leu Leu Phe His Leu Asn Ser 
705                 710                 715                 720 


Lys Ser Ala Leu Gln Arg Ile Ser Val Ala Leu Val Ile Cys Glu Trp 
                725                 730                 735     


Ala Ala Leu Gln Lys Glu Cys Lys Ala Val Xaa Leu Ala Val Gln Pro 
            740                 745                 750         


Arg Leu Leu Asp Ile Leu Ser Glu His Leu Tyr Tyr Asp Glu Ile Ala 
        755                 760                 765             


Val Pro Phe Xaa Arg Met Gln Asn Glu Cys Lys Gln Leu Ile Ser Ser 
    770                 775                 780                 


Leu Ala Asp Val His Ile Glu Val Gly Asn Arg Val Asn Asn Asn Val 
785                 790                 795                 800 


Leu Xaa Ile Asp Gln Ala Ser Asp Leu Val Xaa Xaa Val Phe Asn Glu 
                805                 810                 815     


Ala Xaa Ser Ser Phe Asp Leu Asn Pro Gln Val Leu Gln Gln Leu Asp 
            820                 825                 830         


Ser Lys Arg Gln Gln Val Gln Met Xaa Val Xaa Glu Xaa Asn Gln Glu 
        835                 840                 845             


Trp Gln Val Leu Gln Leu Arg Val His Xaa Phe Ala Ala Cys Ala Val 
    850                 855                 860                 


Val Ser Leu Gln Gln Leu Pro Glu Lys Leu Asn Pro Ile Ile Lys Pro 
865                 870                 875                 880 


Leu Met Glu Xaa Ile Lys Lys Glu Glu Asn Xaa Leu Val Gln Asn Tyr 
                885                 890                 895     


Ala Ala Gln Cys Ile Ala Lys Leu Leu Gln Gln Cys Xaa Xaa Arg Xaa 
            900                 905                 910         


Pro Cys Pro Asn Ser Lys Ile Ile Lys Asn Leu Cys Ser Ser Leu Cys 
        915                 920                 925             


Val Asp Pro Tyr Leu Xaa Pro Cys Val Xaa Cys Pro Val Pro Xaa Gln 
    930                 935                 940                 


Ser Gly Gln Glu Asn Ser Lys Gly Ser Xaa Ser Glu Lys Asp Gly Met 
945                 950                 955                 960 


His His Xaa Val Xaa Lys His Arg Gly Ile Ile Xaa Leu Tyr Arg His 
                965                 970                 975     


Gln Lys Ala Ala Phe Ala Ile Xaa Ser Arg Arg Gly Pro Xaa Pro Lys 
            980                 985                 990         


Ala Val Lys Ala Gln Ile Ala Asp  Leu Pro Ala Gly Ser  Ser Gly Asn 
        995                 1000                 1005             


Ile Leu  Val Glu Leu Asp Glu  Ala Gln Lys Pro Tyr  Leu Val Gln 
    1010                 1015                 1020             


Arg Arg  Gly Ala Glu Phe Ala  Leu Xaa Xaa Ile Val  Lys His Phe 
    1025                 1030                 1035             


Gly Gly  Glu Met Ala Val Lys  Leu Pro His Leu Trp  Asp Ala Met 
    1040                 1045                 1050             


Val Gly  Pro Leu Arg Asn Xaa  Ile Asp Ile Asn Asn  Phe Asp Gly 
    1055                 1060                 1065             


Lys Ser  Leu Leu Asp Lys Gly  Asp Ser Pro Ala Gln  Glu Leu Val 
    1070                 1075                 1080             


Asn Ser  Leu Gln Val Phe Glu  Xaa Ala Ala Ala Ser  Met Asp Ser 
    1085                 1090                 1095             


Glu Leu  His Pro Leu Leu Val  Gln His Leu Pro His  Leu Tyr Met 
    1100                 1105                 1110             


Cys Leu  Gln Tyr Pro Ser Xaa  Ala Val Arg His Met  Ala Ala Arg 
    1115                 1120                 1125             


Cys Val  Gly Val Met Ser Lys  Ile Ala Xaa Met Glu  Xaa Met Asn 
    1130                 1135                 1140             


Ile Phe  Leu Glu Lys Val Leu  Pro Trp Leu Gly Ala  Ile Asp Asp 
    1145                 1150                 1155             


Ser Val  Lys Gln Glu Gly Ala  Ile Glu Ala Leu Ala  Cys Val Met 
    1160                 1165                 1170             


Glu Gln  Leu Asp Val Gly Ile  Val Pro Tyr Ile Val  Leu Leu Val 
    1175                 1180                 1185             


Val Pro  Val Leu Gly Arg Met  Ser Asp Gln Xaa Asp  Ser Val Arg 
    1190                 1195                 1200             


Phe Met  Ala Xaa Gln Cys Phe  Ala Xaa Leu Ile Arg  Leu Met Pro 
    1205                 1210                 1215             


Leu Glu  Ala Gly Ile Pro Asp  Pro Pro Asn Met Ser  Ala Glu Leu 
    1220                 1225                 1230             


Ile Gln  Leu Lys Ala Lys Glu  Arg His Phe Leu Glu  Gln Leu Leu 
    1235                 1240                 1245             


Asp Gly  Lys Lys Leu Glu Asn  Tyr Lys Ile Pro Val  Pro Ile Asn 
    1250                 1255                 1260             


Ala Glu  Leu Arg Lys Tyr Gln  Gln Asp Gly Val Asn  Trp Leu Ala 
    1265                 1270                 1275             


Phe Leu  Asn Lys Tyr Lys Leu  His Gly Ile Leu Cys  Asp Asp Met 
    1280                 1285                 1290             


Gly Leu  Gly Lys Xaa Leu Gln  Ser Ile Cys Ile Leu  Ala Gly Asp 
    1295                 1300                 1305             


His Cys  His Arg Ala Gln Glu  Tyr Ala Arg Ser Lys  Leu Ala Glu 
    1310                 1315                 1320             


Cys Met  Pro Leu Pro Ser Leu  Val Val Cys Pro Pro  Xaa Leu Xaa 
    1325                 1330                 1335             


Gly His  Trp Val Asp Glu Val  Gly Lys Phe Cys Ser  Arg Glu Tyr 
    1340                 1345                 1350             


Leu Asn  Pro Leu His Tyr Xaa  Gly Pro Pro Xaa Glu  Arg Ile Arg 
    1355                 1360                 1365             


Leu Gln  His Gln Val Lys Arg  His Asn Leu Ile Val  Ala Ser Tyr 
    1370                 1375                 1380             


Asp Val  Val Arg Asn Asp Ile  Asp Phe Phe Arg Asn  Ile Lys Phe 
    1385                 1390                 1395             


Asn Tyr  Cys Ile Leu Asp Glu  Gly His Val Ile Lys  Asn Gly Lys 
    1400                 1405                 1410             


Xaa Lys  Leu Ser Lys Ala Val  Lys Gln Leu Xaa Ala  Asn Tyr Arg 
    1415                 1420                 1425             


Ile Ile  Leu Ser Gly Xaa Pro  Ile Gln Asn Asn Val  Leu Glu Leu 
    1430                 1435                 1440             


Trp Ser  Leu Phe Asp Phe Leu  Met Pro Gly Phe Leu  Gly Xaa Glu 
    1445                 1450                 1455             


Arg Gln  Phe Ala Ala Arg Tyr  Gly Lys Pro Ile Leu  Ala Ser Arg 
    1460                 1465                 1470             


Asp Ala  Arg Ser Ser Ser Arg  Glu Gln Glu Ala Gly  Val Leu Ala 
    1475                 1480                 1485             


Met Asp  Ala Leu His Arg Gln  Val Leu Pro Phe Leu  Leu Arg Arg 
    1490                 1495                 1500             


Met Lys  Glu Asp Val Leu Gln  Asp Leu Pro Pro Lys  Ile Ile Gln 
    1505                 1510                 1515             


Asp Tyr  Tyr Cys Xaa Leu Ser  Pro Leu Gln Val Gln  Leu Tyr Glu 
    1520                 1525                 1530             


Asp Phe  Ala Lys Ser Arg Ala  Lys Cys Asp Val Asp  Glu Xaa Val 
    1535                 1540                 1545             


Ser Ser  Ala Xaa Leu Ser Glu  Glu Xaa Glu Lys Pro  Lys Leu Lys 
    1550                 1555                 1560             


Ala Xaa  Gly His Val Phe Gln  Ala Leu Gln Tyr Leu  Arg Lys Leu 
    1565                 1570                 1575             


Cys Asn  His Pro Ala Leu Val  Leu Xaa Pro Gln His  Pro Glu Phe 
    1580                 1585                 1590             


Lys Xaa  Xaa Ala Glu Lys Leu  Ala Val Gln Asn Ser  Ser Leu His 
    1595                 1600                 1605             


Asp Ile  Gln His Ala Pro Lys  Leu Ser Ala Leu Lys  Gln Leu Leu 
    1610                 1615                 1620             


Leu Asp  Cys Gly Leu Gly Asn  Gly Ser Xaa Ser Glu  Ser Gly Xaa 
    1625                 1630                 1635             


Glu Ser  Val Val Ala Gln His  Arg Ile Leu Ile Phe  Cys Gln Leu 
    1640                 1645                 1650             


Lys Ser  Met Leu Asp Ile Val  Glu His Asp Leu Leu  Lys Pro His 
    1655                 1660                 1665             


Leu Pro  Ser Val Xaa Tyr Leu  Arg Leu Asp Gly Ser  Ile Pro Pro 
    1670                 1675                 1680             


Gly Gln  Arg His Ser Ile Val  Ser Arg Phe Asn Asn  Asp Pro Ser 
    1685                 1690                 1695             


Ile Asp  Val Leu Leu Leu Xaa  Xaa His Val Gly Gly  Leu Gly Leu 
    1700                 1705                 1710             


Asn Leu  Xaa Gly Ala Asp Xaa  Val Val Phe Val Glu  His Asp Trp 
    1715                 1720                 1725             


Asn Pro  Met Arg Asp Leu Gln  Ala Met Asp Arg Ala  His Arg Ile 
    1730                 1735                 1740             


Gly Gln  Lys Arg Val Val Asn  Val Tyr Arg Leu Ile  Xaa Arg Gly 
    1745                 1750                 1755             


Xaa Leu  Glu Glu Lys Ile Met  Gly Leu Gln Lys Phe  Lys Met Asn 
    1760                 1765                 1770             


Ile Ala  Asn Xaa Val Ile Ser  Gln Glu Asn Ser Ser  Leu Gln Ser 
    1775                 1780                 1785             


Met Gly  Xaa Asp Gln Leu Leu  Asp Leu Phe Xaa Leu  Asp Lys Asp 
    1790                 1795                 1800             


Gly Lys  Ala Glu Lys Ala Asp  Xaa Ser Xaa Ser Gly  Lys Ala Ser 
    1805                 1810                 1815             


Met Lys  Ser Ile Leu Glu Asn  Leu Ser Asp Leu Trp  Asp Gln Glu 
    1820                 1825                 1830             


Gln Tyr  Asp Ser Glu Tyr Ser  Leu Glu Asn Phe Met  His Ser Leu 
    1835                 1840                 1845             


Lys 
    


<210> 4483
<211> 1849
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1091)..(1091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1120)..(1120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1138)..(1138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1298)..(1298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1338)..(1338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1360)..(1360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1364)..(1364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1424)..(1424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1523)..(1523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1552)..(1552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1557)..(1557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1565)..(1565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1587)..(1587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1595)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1638)..(1638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1673)..(1673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1705)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1716)..(1716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1720)..(1720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1756)..(1756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1759)..(1759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1777)..(1777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1791)..(1791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1799)..(1799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1811)..(1811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1813)..(1813)
<223> Selenocysteine

<400> 4483
Met Gly Val Phe Arg Leu Asp Arg Leu Phe Ile Leu Leu Asp Xaa Gly 
1               5                   10                  15      


Xaa Xaa Pro Val Xaa Arg Lys Ala Ala Ala Gln Gln Leu Gly Glu Val 
            20                  25                  30          


Val Lys Leu His Pro His Glu Leu Asn Asn Leu Leu Ser Lys Val Leu 
        35                  40                  45              


Ile Tyr Leu Arg Ser Ala Asn Trp Asp Xaa Arg Ile Ala Ala Gly Gln 
    50                  55                  60                  


Ala Val Glu Ala Ile Val Lys Asn Val Pro Glu Trp Asn Pro Val Pro 
65                  70                  75                  80  


Arg Xaa Arg Gln Glu Pro Xaa Ser Glu Ser Ser Met Glu Asp Ser Pro 
                85                  90                  95      


Xaa Xaa Glu Arg Leu Asn Phe Asp Arg Phe Asp Ile Cys Arg Leu Leu 
            100                 105                 110         


Gln His Gly Ala Ser Leu Leu Gly Ser Ala Gly Ala Glu Phe Glu Val 
        115                 120                 125             


Gln Asp Glu Lys Ser Gly Glu Val Asp Pro Lys Glu Arg Ile Ala Arg 
    130                 135                 140                 


Gln Arg Lys Leu Leu Gln Lys Lys Leu Gly Leu Asn Met Gly Glu Ala 
145                 150                 155                 160 


Ile Gly Met Ser Xaa Glu Glu Leu Phe Asn Asp Glu Asp Leu Asp Tyr 
                165                 170                 175     


Xaa Pro Xaa Ser Ala Ser Phe Val Asn Lys Gln Pro Xaa Leu Gln Ala 
            180                 185                 190         


Ala Glu Leu Ile Asp Ser Glu Phe Arg Ala Gly Met Ser Asn Arg Gln 
        195                 200                 205             


Lys Asn Lys Ala Lys Arg Met Ala Lys Leu Phe Ala Lys Gln Arg Ser 
    210                 215                 220                 


Arg Asp Ala Val Glu Xaa Asn Glu Lys Ser Asn Asp Ser Xaa Asp Gly 
225                 230                 235                 240 


Glu Pro Glu Glu Lys Arg Arg Lys Ile Ala Asn Val Val Ile Asn Gln 
                245                 250                 255     


Ser Ala Asn Asp Ser Lys Val Leu Ile Asp Asn Ile Pro Asp Ser Ser 
            260                 265                 270         


Ser Leu Ile Glu Glu Xaa Asn Glu Trp Pro Leu Glu Ser Phe Cys Glu 
        275                 280                 285             


Glu Leu Cys Asn Asp Leu Phe Asn Pro Ser Trp Glu Val Arg His Gly 
    290                 295                 300                 


Ala Gly Xaa Gly Leu Arg Glu Ile Leu Lys Ala His Gly Lys Ser Gly 
305                 310                 315                 320 


Gly Lys Met Gly Asp Ser Xaa Leu Glu Glu Met Ile Gln Gln His Gln 
                325                 330                 335     


Glu Trp Leu Glu Asp Leu Val Ile Arg Leu Leu Cys Val Phe Ala Leu 
            340                 345                 350         


Asp Arg Phe Gly Asp Phe Val Ser Asp Glu Val Val Ala Pro Val Arg 
        355                 360                 365             


Glu Xaa Cys Ala Gln Xaa Leu Gly Val Val Leu Lys His Met Asn Glu 
    370                 375                 380                 


Xaa Gly Val His Lys Xaa Val Asp Val Leu Leu Lys Leu Leu Xaa Gln 
385                 390                 395                 400 


Glu Gln Trp Glu Val Arg His Gly Gly Leu Leu Gly Ile Lys Tyr Ala 
                405                 410                 415     


Leu Ala Val Arg Gln Asp Val Ile Asn Xaa Leu Leu Pro Lys Val Leu 
            420                 425                 430         


Xaa Arg Ile Ile Glu Gly Leu Gln Asp Leu Asp Asp Asp Val Arg Ala 
        435                 440                 445             


Val Ala Ala Ala Ser Leu Val Pro Val Val Glu Ser Leu Val Tyr Leu 
    450                 455                 460                 


Gln Xaa Gln Lys Val Pro Phe Ile Ile Asn Xaa Leu Trp Asp Ala Leu 
465                 470                 475                 480 


Leu Glu Leu Asp Asp Leu Xaa Ala Ser Xaa Asn Ser Ile Met Xaa Leu 
                485                 490                 495     


Leu Ser Ser Leu Leu Xaa Tyr Pro Gln Val Gln Gln Cys Ser Ile Gln 
            500                 505                 510         


Gln Ser Leu Xaa Val Leu Val Pro Arg Val Trp Pro Phe Leu His His 
        515                 520                 525             


Xaa Ile Ser Ser Val Arg Arg Ala Ala Leu Glu Xaa Leu Phe Xaa Leu 
    530                 535                 540                 


Leu Ser Xaa Gln Asp Gln Asn Ser Ser Ser Trp Leu Ile Pro Ile Leu 
545                 550                 555                 560 


Pro Asp Met Leu Arg His Ile Phe Gln Phe Cys Val Leu Glu Ser Ser 
                565                 570                 575     


Gln Glu Ile Leu Asp Leu Ile His Lys Val Trp Met Glu Leu Leu Ser 
            580                 585                 590         


Lys Ala Ser Val Gln Tyr Val Val Ala Ala Ala Cys Pro Trp Met Gly 
        595                 600                 605             


Ala Trp Leu Cys Leu Met Met Gln Pro Ser His Leu Pro Ile Asp Leu 
    610                 615                 620                 


Asn Met Leu Leu Glu Val Lys Ala Arg Ala Lys Glu Lys Xaa Gly Gly 
625                 630                 635                 640 


Lys Val Arg Gln Gly Gln Ser Gln Asn Lys Glu Val Leu Gln Glu Tyr 
                645                 650                 655     


Ile Ala Gly Ala Asp Xaa Ile Met Glu Asp Pro Ala Xaa Arg Asp Phe 
            660                 665                 670         


Val Val Met Arg Ala Arg Met Met Ala Ala Lys Leu Leu Gly Ala Leu 
        675                 680                 685             


Cys Cys Cys Ile Cys Asp Pro Gly Val Asn Val Val Xaa Gln Glu Ile 
    690                 695                 700                 


Lys Pro Ala Glu Ser Leu Gly Gln Leu Leu Leu Phe His Leu Asn Ser 
705                 710                 715                 720 


Lys Ser Ala Leu Gln Arg Ile Ser Val Ala Leu Val Ile Cys Glu Trp 
                725                 730                 735     


Ala Ala Leu Gln Lys Glu Cys Lys Ala Val Xaa Leu Ala Val Gln Pro 
            740                 745                 750         


Arg Leu Leu Asp Ile Leu Ser Glu His Leu Tyr Tyr Asp Glu Ile Ala 
        755                 760                 765             


Val Pro Phe Xaa Arg Met Gln Asn Glu Cys Lys Gln Leu Ile Ser Ser 
    770                 775                 780                 


Leu Ala Asp Val His Ile Glu Val Gly Asn Arg Val Asn Asn Asn Val 
785                 790                 795                 800 


Leu Xaa Ile Asp Gln Ala Ser Asp Leu Val Xaa Xaa Val Phe Asn Glu 
                805                 810                 815     


Ala Xaa Ser Ser Phe Asp Leu Asn Pro Gln Val Leu Gln Gln Leu Asp 
            820                 825                 830         


Ser Lys Arg Gln Gln Val Gln Met Xaa Val Xaa Glu Xaa Asn Gln Glu 
        835                 840                 845             


Trp Gln Val Leu Gln Leu Arg Val His Xaa Phe Ala Ala Cys Ala Val 
    850                 855                 860                 


Val Ser Leu Gln Gln Leu Pro Glu Lys Leu Asn Pro Ile Ile Lys Pro 
865                 870                 875                 880 


Leu Met Glu Xaa Ile Lys Lys Glu Glu Asn Xaa Leu Val Gln Asn Tyr 
                885                 890                 895     


Ala Ala Gln Cys Ile Ala Lys Leu Leu Gln Gln Cys Xaa Xaa Arg Xaa 
            900                 905                 910         


Pro Cys Pro Asn Ser Lys Ile Ile Lys Asn Leu Cys Ser Ser Leu Cys 
        915                 920                 925             


Val Asp Pro Tyr Leu Xaa Pro Cys Val Xaa Cys Pro Val Pro Xaa Gln 
    930                 935                 940                 


Ser Gly Gln Glu Asn Ser Lys Gly Ser Xaa Ser Glu Lys Asp Gly Met 
945                 950                 955                 960 


His His Xaa Val Xaa Lys His Arg Gly Ile Ile Xaa Leu Tyr Arg His 
                965                 970                 975     


Gln Lys Ala Ala Phe Ala Ile Xaa Ser Arg Arg Gly Pro Xaa Pro Lys 
            980                 985                 990         


Ala Val Lys Ala Gln Ile Ala Asp  Leu Pro Ala Gly Ser  Ser Gly Asn 
        995                 1000                 1005             


Ile Leu  Val Glu Leu Asp Glu  Ala Gln Lys Pro Tyr  Leu Val Gln 
    1010                 1015                 1020             


Arg Arg  Gly Ala Glu Phe Ala  Leu Xaa Xaa Ile Val  Lys His Phe 
    1025                 1030                 1035             


Gly Gly  Glu Met Ala Val Lys  Leu Pro His Leu Trp  Asp Ala Met 
    1040                 1045                 1050             


Val Gly  Pro Leu Arg Asn Xaa  Ile Asp Ile Asn Asn  Phe Asp Gly 
    1055                 1060                 1065             


Lys Ser  Leu Leu Asp Lys Gly  Asp Ser Pro Ala Gln  Glu Leu Val 
    1070                 1075                 1080             


Asn Ser  Leu Gln Val Phe Glu  Xaa Ala Ala Ala Ser  Met Asp Ser 
    1085                 1090                 1095             


Glu Leu  His Pro Leu Leu Val  Gln His Leu Pro His  Leu Tyr Met 
    1100                 1105                 1110             


Cys Leu  Gln Tyr Pro Ser Xaa  Ala Val Arg His Met  Ala Ala Arg 
    1115                 1120                 1125             


Cys Val  Gly Val Met Ser Lys  Ile Ala Xaa Met Glu  Xaa Met Asn 
    1130                 1135                 1140             


Ile Phe  Leu Glu Lys Val Leu  Pro Trp Leu Gly Ala  Ile Asp Asp 
    1145                 1150                 1155             


Ser Val  Lys Gln Glu Gly Ala  Ile Glu Ala Leu Ala  Cys Val Met 
    1160                 1165                 1170             


Glu Gln  Leu Asp Val Gly Ile  Val Pro Tyr Ile Val  Leu Leu Val 
    1175                 1180                 1185             


Val Pro  Val Leu Gly Arg Met  Ser Asp Gln Xaa Asp  Ser Val Arg 
    1190                 1195                 1200             


Phe Met  Ala Xaa Gln Cys Phe  Ala Xaa Leu Ile Arg  Leu Met Pro 
    1205                 1210                 1215             


Leu Glu  Ala Gly Ile Pro Asp  Pro Pro Asn Met Ser  Ala Glu Leu 
    1220                 1225                 1230             


Ile Gln  Leu Lys Ala Lys Glu  Arg His Phe Leu Glu  Gln Leu Leu 
    1235                 1240                 1245             


Asp Gly  Lys Lys Leu Glu Asn  Tyr Lys Ile Pro Val  Pro Ile Asn 
    1250                 1255                 1260             


Ala Glu  Leu Arg Lys Tyr Gln  Gln Asp Gly Val Asn  Trp Leu Ala 
    1265                 1270                 1275             


Phe Leu  Asn Lys Tyr Lys Leu  His Gly Ile Leu Cys  Asp Asp Met 
    1280                 1285                 1290             


Gly Leu  Gly Lys Xaa Leu Gln  Ser Ile Cys Ile Leu  Ala Gly Asp 
    1295                 1300                 1305             


His Cys  His Arg Ala Gln Glu  Tyr Ala Arg Ser Lys  Leu Ala Glu 
    1310                 1315                 1320             


Cys Met  Pro Leu Pro Ser Leu  Val Val Cys Pro Pro  Xaa Leu Xaa 
    1325                 1330                 1335             


Gly His  Trp Val Asp Glu Val  Gly Lys Phe Cys Ser  Arg Glu Tyr 
    1340                 1345                 1350             


Leu Asn  Pro Leu His Tyr Xaa  Gly Pro Pro Xaa Glu  Arg Ile Arg 
    1355                 1360                 1365             


Leu Gln  His Gln Val Lys Arg  His Asn Leu Ile Val  Ala Ser Tyr 
    1370                 1375                 1380             


Asp Val  Val Arg Asn Asp Ile  Asp Phe Phe Arg Asn  Ile Lys Phe 
    1385                 1390                 1395             


Asn Tyr  Cys Ile Leu Asp Glu  Gly His Val Ile Lys  Asn Gly Lys 
    1400                 1405                 1410             


Xaa Lys  Leu Ser Lys Ala Val  Lys Gln Leu Xaa Ala  Asn Tyr Arg 
    1415                 1420                 1425             


Ile Ile  Leu Ser Gly Xaa Pro  Ile Gln Asn Asn Val  Leu Glu Leu 
    1430                 1435                 1440             


Trp Ser  Leu Phe Asp Phe Leu  Met Pro Gly Phe Leu  Gly Xaa Glu 
    1445                 1450                 1455             


Arg Gln  Phe Ala Ala Arg Tyr  Gly Lys Pro Ile Leu  Ala Ser Arg 
    1460                 1465                 1470             


Asp Ala  Arg Ser Ser Ser Arg  Glu Gln Glu Ala Gly  Val Leu Ala 
    1475                 1480                 1485             


Met Asp  Ala Leu His Arg Gln  Val Leu Pro Phe Leu  Leu Arg Arg 
    1490                 1495                 1500             


Met Lys  Glu Asp Val Leu Gln  Asp Leu Pro Pro Lys  Ile Ile Gln 
    1505                 1510                 1515             


Asp Tyr  Tyr Cys Xaa Leu Ser  Pro Leu Gln Val Gln  Leu Tyr Glu 
    1520                 1525                 1530             


Asp Phe  Ala Lys Ser Arg Ala  Lys Cys Asp Val Asp  Glu Xaa Val 
    1535                 1540                 1545             


Ser Ser  Ala Xaa Leu Ser Glu  Glu Xaa Glu Lys Pro  Lys Leu Lys 
    1550                 1555                 1560             


Ala Xaa  Gly His Val Phe Gln  Ala Leu Gln Tyr Leu  Arg Lys Leu 
    1565                 1570                 1575             


Cys Asn  His Pro Ala Leu Val  Leu Xaa Pro Gln His  Pro Glu Phe 
    1580                 1585                 1590             


Lys Xaa  Xaa Ala Glu Lys Leu  Ala Val Gln Asn Ser  Ser Leu His 
    1595                 1600                 1605             


Asp Ile  Gln His Ala Pro Lys  Leu Ser Ala Leu Lys  Gln Leu Leu 
    1610                 1615                 1620             


Leu Asp  Cys Gly Leu Gly Asn  Gly Ser Xaa Ser Glu  Ser Gly Xaa 
    1625                 1630                 1635             


Glu Ser  Val Val Ala Gln His  Arg Ile Leu Ile Phe  Cys Gln Leu 
    1640                 1645                 1650             


Lys Ser  Met Leu Asp Ile Val  Glu His Asp Leu Leu  Lys Pro His 
    1655                 1660                 1665             


Leu Pro  Ser Val Xaa Tyr Leu  Arg Leu Asp Gly Ser  Ile Pro Pro 
    1670                 1675                 1680             


Gly Gln  Arg His Ser Ile Val  Ser Arg Phe Asn Asn  Asp Pro Ser 
    1685                 1690                 1695             


Ile Asp  Val Leu Leu Leu Xaa  Xaa His Val Gly Gly  Leu Gly Leu 
    1700                 1705                 1710             


Asn Leu  Xaa Gly Ala Asp Xaa  Val Val Phe Val Glu  His Asp Trp 
    1715                 1720                 1725             


Asn Pro  Met Arg Asp Leu Gln  Ala Met Asp Arg Ala  His Arg Ile 
    1730                 1735                 1740             


Gly Gln  Lys Arg Val Val Asn  Val Tyr Arg Leu Ile  Xaa Arg Gly 
    1745                 1750                 1755             


Xaa Leu  Glu Glu Lys Ile Met  Gly Leu Gln Lys Phe  Lys Met Asn 
    1760                 1765                 1770             


Ile Ala  Asn Xaa Val Ile Ser  Gln Glu Asn Ser Ser  Leu Gln Ser 
    1775                 1780                 1785             


Met Gly  Xaa Asp Gln Leu Leu  Asp Leu Phe Xaa Leu  Asp Lys Asp 
    1790                 1795                 1800             


Gly Lys  Ala Glu Lys Ala Asp  Xaa Ser Xaa Ser Gly  Lys Ala Ser 
    1805                 1810                 1815             


Met Lys  Ser Ile Leu Glu Asn  Leu Ser Asp Leu Trp  Asp Gln Glu 
    1820                 1825                 1830             


Gln Tyr  Asp Ser Glu Tyr Ser  Leu Glu Asn Phe Met  His Ser Leu 
    1835                 1840                 1845             


Lys 
    


<210> 4484
<211> 222
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<400> 4484
Ala Ala Ala Ala Val Pro Pro Ala Ala Ala Ala Asn His His His His 
1               5                   10                  15      


His His His Ala Leu His Glu Ala Pro Lys Phe Xaa Val Glu Xaa Leu 
            20                  25                  30          


Glu His Xaa Val Asn Asn Asp Ser Glu Ile Trp Gly Leu Leu Gln Pro 
        35                  40                  45              


Tyr Gln His Leu Ile Cys Gly Lys Asn Ala Ser Gly Asp Leu Val Ser 
    50                  55                  60                  


Arg Ala Met His His Leu Gln Pro Leu Asn Ala Lys His His Gly Asn 
65                  70                  75                  80  


Gly Xaa Pro Leu His His Lys Gln Gly Ala Leu Tyr Trp Glu Pro Glu 
                85                  90                  95      


Ala Leu Tyr Xaa Leu Cys Tyr Phe Met His Cys Pro Gln Met Glu Trp 
            100                 105                 110         


Glu Asn Pro Asn Val Glu Pro Ser Lys Val Asn Leu Gln Val Glu Arg 
        115                 120                 125             


Pro Phe Leu Val Leu Pro Pro Leu Met Glu Trp Ile Arg Val Ala Val 
    130                 135                 140                 


Ala His Ala Gly His Arg Arg Ser Phe Ser Met Asp Ser Asp Asp Val 
145                 150                 155                 160 


Arg Gln Ala Ala Arg Leu Leu Leu Pro Gly Val Asp Cys Glu Pro Arg 
                165                 170                 175     


Gln Leu Arg Ala Asp Asp Cys Phe Cys Ala Ser Arg Lys Leu Asp Ala 
            180                 185                 190         


Val Ala Ile Glu Ala Lys Phe Lys Gln Asp Leu Gly Phe Arg Met Leu 
        195                 200                 205             


Asn Cys Gly Arg Xaa Asp Leu Val Lys Gln Ala Val Ser Leu 
    210                 215                 220         


<210> 4485
<211> 985
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<400> 4485
Met Ala Arg Arg Gly Lys Lys Pro Val Val Arg Xaa Leu Glu Asp Leu 
1               5                   10                  15      


Xaa Leu Asp Ser Gly Tyr Gly Gly Ala Ala Asp Ser Val Arg Ser Ser 
            20                  25                  30          


Asn Leu Ser Leu Cys Cys Ser Asp Ser His Pro Ala Ser Pro Tyr Gly 
        35                  40                  45              


Gly Ser Cys Trp Pro Pro Leu Ala Asp Ser Met His Ser Arg His Asn 
    50                  55                  60                  


Ser Phe Asp Xaa Val Asn Xaa Ala Leu Val Glu Asp Ser Glu Gly Leu 
65                  70                  75                  80  


Asp Cys Ala Gly Gln His Cys Ser Arg Leu Leu Pro Asp Leu Asp Glu 
                85                  90                  95      


Val Pro Trp Xaa Leu Gln Glu Leu Glu Ala Leu Leu Leu Arg Ser Arg 
            100                 105                 110         


Asp Pro Arg Ala Gly Pro Ala Val Pro Gly Gly Leu Pro Lys Asp Ala 
        115                 120                 125             


Leu Ala Lys Leu Ser Xaa Leu Val Ser Arg Ala Leu Val Arg Ile Ala 
    130                 135                 140                 


Lys Glu Ala Gln Arg Leu Ser Leu Arg Phe Ala Lys Cys Xaa Lys Tyr 
145                 150                 155                 160 


Glu Ile Gln Ser Ala Met Glu Ile Val Leu Ser Trp Gly Leu Ala Ala 
                165                 170                 175     


His Cys Xaa Ala Ala Ala Leu Ala Ala Leu Ser Leu Tyr Asn Met Ser 
            180                 185                 190         


Ser Ala Gly Gly Asp Arg Leu Gly Arg Gly Lys Ser Ala Arg Cys Gly 
        195                 200                 205             


Leu Xaa Phe Ser Val Gly Arg Val Tyr Arg Trp Met Val Asp Ser Arg 
    210                 215                 220                 


Val Ala Leu Arg Ile His Glu His Ala Ala Ile Tyr Leu Xaa Ala Cys 
225                 230                 235                 240 


Met Glu Ser Leu Phe Arg Asp Ile Tyr Ser Arg Val Val Ala Ser Gly 
                245                 250                 255     


Val Pro Arg Ser Cys Ser Gly Pro Gly Ser Gly Ser Gly Ser Gly Pro 
            260                 265                 270         


Gly Pro Ser Ser Gly Pro Gly Ala Ala Pro Ala Ala Asp Lys Glu Arg 
        275                 280                 285             


Glu Ala Pro Gly Gly Gly Ala Ala Ser Gly Gly Ala Cys Ser Ala Ala 
    290                 295                 300                 


Ser Ser Ala Ser Gly Gly Ser Ser Cys Cys Ala Pro Pro Ala Ala Ala 
305                 310                 315                 320 


Ala Ala Ala Val Pro Pro Ala Ala Ala Ala Asn His His His His His 
                325                 330                 335     


His His Ala Leu His Glu Ala Pro Lys Phe Xaa Val Glu Xaa Leu Glu 
            340                 345                 350         


His Xaa Val Asn Asn Asp Ser Glu Ile Trp Gly Leu Leu Gln Pro Tyr 
        355                 360                 365             


Gln His Leu Ile Cys Gly Lys Asn Ala Ser Gly Val Leu Cys Leu Pro 
    370                 375                 380                 


Asp Ser Leu Asn Leu His Arg Asp Pro Gln Arg Ser Asn Lys Pro Gly 
385                 390                 395                 400 


Glu Leu Pro Met Phe Ser Gln Ser Glu Leu Arg Xaa Ile Glu Gln Ser 
                405                 410                 415     


Leu Leu Ala Xaa Arg Val Gly Ser Ile Ala Glu Leu Ser Asp Leu Val 
            420                 425                 430         


Ser Arg Ala Met His His Leu Gln Pro Leu Asn Ala Lys His His Gly 
        435                 440                 445             


Asn Gly Xaa Pro Leu His His Lys Gln Gly Ala Leu Tyr Trp Glu Pro 
    450                 455                 460                 


Glu Ala Leu Tyr Xaa Leu Cys Tyr Phe Met His Cys Pro Gln Met Glu 
465                 470                 475                 480 


Trp Glu Asn Pro Asn Val Glu Pro Ser Lys Val Asn Leu Gln Val Glu 
                485                 490                 495     


Arg Pro Phe Leu Val Leu Pro Pro Leu Met Glu Trp Ile Arg Val Ala 
            500                 505                 510         


Val Ala His Ala Gly His Arg Arg Ser Phe Ser Met Asp Ser Asp Asp 
        515                 520                 525             


Val Arg Gln Ala Ala Arg Leu Leu Leu Pro Gly Val Asp Cys Glu Pro 
    530                 535                 540                 


Arg Gln Leu Arg Ala Asp Asp Cys Phe Cys Ala Ser Arg Lys Leu Asp 
545                 550                 555                 560 


Ala Val Ala Ile Glu Ala Lys Phe Lys Gln Asp Leu Gly Phe Arg Met 
                565                 570                 575     


Leu Asn Cys Gly Arg Xaa Asp Leu Val Lys Gln Ala Val Ser Leu Leu 
            580                 585                 590         


Gly Pro Asp Gly Ile Asn Xaa Met Ser Glu Gln Gly Met Xaa Pro Leu 
        595                 600                 605             


Met Tyr Ala Cys Val Arg Gly Asp Glu Ala Met Val Gln Met Leu Leu 
    610                 615                 620                 


Asp Ala Gly Ala Asp Leu Asn Val Glu Val Val Ser Xaa Pro His Lys 
625                 630                 635                 640 


Tyr Pro Ser Val His Pro Glu Xaa Arg His Trp Xaa Ala Leu Xaa Phe 
                645                 650                 655     


Ala Val Leu His Gly His Ile Pro Val Val Gln Leu Leu Leu Asp Ala 
            660                 665                 670         


Gly Ala Lys Val Glu Gly Ser Val Glu His Gly Glu Glu Asn Tyr Ser 
        675                 680                 685             


Glu Xaa Pro Leu Gln Leu Ala Ala Ala Val Gly Val Pro Trp Xaa Leu 
    690                 695                 700                 


His Xaa Trp Leu Glu Ser Leu Arg Ile Ala Phe Gln Gln His Arg Arg 
705                 710                 715                 720 


Pro Leu Ile Gln Cys Leu Leu Lys Glu Phe Lys Xaa Ile Gln Glu Glu 
                725                 730                 735     


Glu Tyr Xaa Glu Glu Leu Val Xaa Gln Gly Leu Pro Leu Met Phe Glu 
            740                 745                 750         


Ile Leu Lys Ala Ser Lys Asn Glu Val Ile Ser Gln Gln Leu Cys Val 
        755                 760                 765             


Ile Phe Xaa His Cys Tyr Gly Pro Tyr Pro Ile Pro Lys Leu Xaa Glu 
    770                 775                 780                 


Ile Lys Arg Lys Gln Xaa Ser Arg Leu Asp Pro His Phe Leu Asn Asn 
785                 790                 795                 800 


Lys Glu Met Ser Asp Val Xaa Phe Leu Val Glu Gly Arg Pro Phe Tyr 
                805                 810                 815     


Ala His Lys Val Leu Leu Phe Xaa Ala Ser Pro Arg Phe Lys Ala Leu 
            820                 825                 830         


Leu Ser Ser Lys Pro Xaa Asn Asp Gly Xaa Cys Ile Glu Ile Gly Tyr 
        835                 840                 845             


Val Lys Tyr Ser Ile Phe Gln Leu Val Met Gln Tyr Leu Tyr Tyr Gly 
    850                 855                 860                 


Gly Pro Glu Ser Leu Leu Ile Lys Asn Asn Glu Ile Met Glu Leu Leu 
865                 870                 875                 880 


Ser Ala Ala Lys Phe Phe Gln Leu Glu Ala Leu Gln Arg His Cys Glu 
                885                 890                 895     


Ile Ile Cys Ala Lys Ser Ile Asn Xaa Asp Asn Cys Val Asp Ile Tyr 
            900                 905                 910         


Asn His Ala Lys Phe Leu Gly Val Xaa Glu Leu Ser Ala Tyr Cys Glu 
        915                 920                 925             


Gly Tyr Phe Leu Lys Asn Met Met Val Leu Ile Glu Asn Glu Ala Phe 
    930                 935                 940                 


Lys Gln Leu Leu Tyr Asp Lys Asn Gly Glu Gly Xaa Gly Gln Asp Val 
945                 950                 955                 960 


Leu Gln Asp Leu Gln Arg Xaa Leu Ala Ile Arg Ile Gln Ser Ile His 
                965                 970                 975     


Leu Ser Ser Ser Lys Gly Ser Val Val 
            980                 985 


<210> 4486
<211> 1007
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<400> 4486
Met Ala Arg Arg Gly Lys Lys Pro Val Val Arg Xaa Leu Glu Asp Leu 
1               5                   10                  15      


Xaa Leu Asp Ser Gly Tyr Gly Gly Ala Ala Asp Ser Val Arg Ser Ser 
            20                  25                  30          


Asn Leu Ser Leu Cys Cys Ser Asp Ser His Pro Ala Ser Pro Tyr Gly 
        35                  40                  45              


Gly Ser Cys Trp Pro Pro Leu Ala Asp Ser Met His Ser Arg His Asn 
    50                  55                  60                  


Ser Phe Asp Xaa Val Asn Xaa Ala Leu Val Glu Asp Ser Glu Gly Leu 
65                  70                  75                  80  


Asp Cys Ala Gly Gln His Cys Ser Arg Leu Leu Pro Asp Leu Asp Glu 
                85                  90                  95      


Val Pro Trp Xaa Leu Gln Glu Leu Glu Ala Leu Leu Leu Arg Ser Arg 
            100                 105                 110         


Asp Pro Arg Ala Gly Pro Ala Val Pro Gly Gly Leu Pro Lys Asp Ala 
        115                 120                 125             


Leu Ala Lys Leu Ser Xaa Leu Val Ser Arg Ala Leu Val Arg Ile Ala 
    130                 135                 140                 


Lys Glu Ala Gln Arg Leu Ser Leu Arg Phe Ala Lys Cys Xaa Lys Tyr 
145                 150                 155                 160 


Glu Ile Gln Ser Ala Met Glu Ile Val Leu Ser Trp Gly Leu Ala Ala 
                165                 170                 175     


His Cys Xaa Ala Ala Ala Leu Ala Ala Leu Ser Leu Tyr Asn Met Ser 
            180                 185                 190         


Ser Ala Gly Gly Asp Arg Leu Gly Arg Gly Lys Ser Ala Arg Cys Gly 
        195                 200                 205             


Leu Xaa Phe Ser Val Gly Arg Val Tyr Arg Trp Met Val Asp Ser Arg 
    210                 215                 220                 


Val Ala Leu Arg Ile His Glu His Ala Ala Ile Tyr Leu Xaa Ala Cys 
225                 230                 235                 240 


Met Glu Ser Leu Phe Arg Asp Ile Tyr Ser Arg Val Val Ala Ser Gly 
                245                 250                 255     


Val Pro Arg Ser Cys Ser Gly Pro Gly Ser Gly Ser Gly Ser Gly Pro 
            260                 265                 270         


Gly Pro Ser Ser Gly Pro Gly Ala Ala Pro Ala Ala Asp Lys Glu Arg 
        275                 280                 285             


Glu Ala Pro Gly Gly Gly Ala Ala Ser Gly Gly Ala Cys Ser Ala Ala 
    290                 295                 300                 


Ser Ser Ala Ser Gly Gly Ser Ser Cys Cys Ala Pro Pro Ala Ala Ala 
305                 310                 315                 320 


Ala Ala Ala Val Pro Pro Ala Ala Ala Ala Asn His His His His His 
                325                 330                 335     


His His Ala Leu His Glu Ala Pro Lys Phe Xaa Val Glu Xaa Leu Glu 
            340                 345                 350         


His Xaa Val Asn Asn Asp Ser Glu Ile Trp Gly Leu Leu Gln Pro Tyr 
        355                 360                 365             


Gln His Leu Ile Cys Gly Lys Asn Ala Ser Gly Val Leu Cys Leu Pro 
    370                 375                 380                 


Asp Ser Leu Asn Leu His Arg Asp Pro Gln Arg Ser Asn Lys Pro Gly 
385                 390                 395                 400 


Glu Leu Pro Met Phe Ser Gln Ser Glu Leu Arg Xaa Ile Glu Gln Ser 
                405                 410                 415     


Leu Leu Ala Xaa Arg Val Gly Ser Ile Ala Glu Leu Ser Asp Leu Val 
            420                 425                 430         


Ser Arg Ala Met His His Leu Gln Pro Leu Asn Ala Lys His His Gly 
        435                 440                 445             


Asn Gly Xaa Pro Leu His His Lys Gln Gly Ala Leu Tyr Trp Glu Pro 
    450                 455                 460                 


Glu Ala Leu Tyr Xaa Leu Cys Tyr Phe Met His Cys Pro Gln Met Glu 
465                 470                 475                 480 


Trp Glu Asn Pro Asn Val Glu Pro Ser Lys Val Asn Leu Gln Val Glu 
                485                 490                 495     


Arg Pro Phe Leu Val Leu Pro Pro Leu Met Glu Trp Ile Arg Val Ala 
            500                 505                 510         


Val Ala His Ala Gly His Arg Arg Ser Phe Ser Met Asp Ser Asp Asp 
        515                 520                 525             


Val Arg Gln Ala Ala Arg Leu Leu Leu Pro Gly Val Asp Cys Glu Pro 
    530                 535                 540                 


Arg Gln Leu Arg Ala Asp Asp Cys Phe Cys Ala Ser Arg Lys Leu Asp 
545                 550                 555                 560 


Ala Val Ala Ile Glu Ala Lys Phe Lys Gln Asp Leu Gly Phe Arg Met 
                565                 570                 575     


Leu Asn Cys Gly Arg Xaa Asp Leu Val Lys Gln Ala Val Ser Leu Leu 
            580                 585                 590         


Gly Pro Asp Gly Ile Asn Xaa Met Ser Glu Gln Gly Met Xaa Pro Leu 
        595                 600                 605             


Met Tyr Ala Cys Val Arg Gly Asp Glu Ala Met Val Gln Met Leu Leu 
    610                 615                 620                 


Asp Ala Gly Ala Asp Leu Asn Val Glu Val Val Ser Xaa Pro His Lys 
625                 630                 635                 640 


Tyr Pro Ser Val His Pro Glu Xaa Arg His Trp Xaa Ala Leu Xaa Phe 
                645                 650                 655     


Ala Val Leu His Gly His Ile Pro Val Val Gln Leu Leu Leu Asp Ala 
            660                 665                 670         


Gly Ala Lys Val Glu Gly Ser Val Glu His Gly Glu Glu Asn Tyr Ser 
        675                 680                 685             


Glu Xaa Pro Leu Gln Leu Ala Ala Ala Val Gly Asn Phe Glu Leu Val 
    690                 695                 700                 


Ser Leu Leu Leu Glu Arg Gly Ala Asp Pro Leu Ile Gly Xaa Met Tyr 
705                 710                 715                 720 


Arg Asn Gly Ile Ser Xaa Xaa Pro Gln Gly Asp Met Asn Ser Phe Ser 
                725                 730                 735     


Gln Ala Ala Ala His Gly His Arg Asn Val Phe Arg Lys Leu Leu Ala 
            740                 745                 750         


Gln Pro Glu Lys Glu Lys Ser Asp Ile Leu Ser Leu Glu Glu Ile Leu 
        755                 760                 765             


Ala Glu Gly Xaa Asp Leu Ala Glu Xaa Ala Pro Pro Pro Leu Cys Ala 
    770                 775                 780                 


Ser Arg Asn Ser Lys Ala Lys Leu Arg Ala Leu Arg Glu Ala Met Tyr 
785                 790                 795                 800 


His Ser Ala Glu His Gly Tyr Val Asp Val Xaa Ile Asp Ile Arg Ser 
                805                 810                 815     


Ile Gly Val Pro Trp Xaa Leu His Xaa Trp Leu Glu Ser Leu Arg Ile 
            820                 825                 830         


Ala Phe Gln Gln His Arg Arg Pro Leu Ile Gln Cys Leu Leu Lys Glu 
        835                 840                 845             


Phe Lys Xaa Ile Gln Glu Glu Glu Tyr Xaa Glu Glu Leu Val Xaa Gln 
    850                 855                 860                 


Gly Leu Pro Leu Met Phe Glu Ile Leu Lys Ala Ser Lys Asn Glu Val 
865                 870                 875                 880 


Ile Ser Gln Gln Leu Cys Val Ile Phe Xaa His Cys Tyr Gly Pro Tyr 
                885                 890                 895     


Pro Ile Pro Lys Leu Xaa Glu Ile Lys Arg Lys Gln Xaa Ser Arg Leu 
            900                 905                 910         


Asp Pro His Phe Leu Asn Asn Lys Glu Met Ser Asp Val Xaa Phe Leu 
        915                 920                 925             


Val Glu Gly Arg Pro Phe Tyr Ala His Lys Val Leu Leu Phe Xaa Ala 
    930                 935                 940                 


Ser Pro Arg Phe Lys Ala Leu Leu Ser Ser Lys Pro Xaa Asn Asp Gly 
945                 950                 955                 960 


Xaa Cys Ile Glu Ile Gly Tyr Val Lys Tyr Ser Ile Phe Gln Leu Val 
                965                 970                 975     


Met Gln Tyr Leu Tyr Tyr Gly Gly Pro Glu Ser Leu Leu Ile Lys Asn 
            980                 985                 990         


Asn Glu Ile Met Glu Val Arg Asp  Pro Leu Trp Cys Trp  Leu Ser 
        995                 1000                 1005         


<210> 4487
<211> 1104
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<400> 4487
Met Ala Arg Arg Gly Lys Lys Pro Val Val Arg Xaa Leu Glu Asp Leu 
1               5                   10                  15      


Xaa Leu Asp Ser Gly Tyr Gly Gly Ala Ala Asp Ser Val Arg Ser Ser 
            20                  25                  30          


Asn Leu Ser Leu Cys Cys Ser Asp Ser His Pro Ala Ser Pro Tyr Gly 
        35                  40                  45              


Gly Ser Cys Trp Pro Pro Leu Ala Asp Ser Met His Ser Arg His Asn 
    50                  55                  60                  


Ser Phe Asp Xaa Val Asn Xaa Ala Leu Val Glu Asp Ser Glu Gly Leu 
65                  70                  75                  80  


Asp Cys Ala Gly Gln His Cys Ser Arg Leu Leu Pro Asp Leu Asp Glu 
                85                  90                  95      


Val Pro Trp Xaa Leu Gln Glu Leu Glu Ala Leu Leu Leu Arg Ser Arg 
            100                 105                 110         


Asp Pro Arg Ala Gly Pro Ala Val Pro Gly Gly Leu Pro Lys Asp Ala 
        115                 120                 125             


Leu Ala Lys Leu Ser Xaa Leu Val Ser Arg Ala Leu Val Arg Ile Ala 
    130                 135                 140                 


Lys Glu Ala Gln Arg Leu Ser Leu Arg Phe Ala Lys Cys Xaa Lys Tyr 
145                 150                 155                 160 


Glu Ile Gln Ser Ala Met Glu Ile Val Leu Ser Trp Gly Leu Ala Ala 
                165                 170                 175     


His Cys Xaa Ala Ala Ala Leu Ala Ala Leu Ser Leu Tyr Asn Met Ser 
            180                 185                 190         


Ser Ala Gly Gly Asp Arg Leu Gly Arg Gly Lys Ser Ala Arg Cys Gly 
        195                 200                 205             


Leu Xaa Phe Ser Val Gly Arg Val Tyr Arg Trp Met Val Asp Ser Arg 
    210                 215                 220                 


Val Ala Leu Arg Ile His Glu His Ala Ala Ile Tyr Leu Xaa Ala Cys 
225                 230                 235                 240 


Met Glu Ser Leu Phe Arg Asp Ile Tyr Ser Arg Val Val Ala Ser Gly 
                245                 250                 255     


Val Pro Arg Ser Cys Ser Gly Pro Gly Ser Gly Ser Gly Ser Gly Pro 
            260                 265                 270         


Gly Pro Ser Ser Gly Pro Gly Ala Ala Pro Ala Ala Asp Lys Glu Arg 
        275                 280                 285             


Glu Ala Pro Gly Gly Gly Ala Ala Ser Gly Gly Ala Cys Ser Ala Ala 
    290                 295                 300                 


Ser Ser Ala Ser Gly Gly Ser Ser Cys Cys Ala Pro Pro Ala Ala Ala 
305                 310                 315                 320 


Ala Ala Ala Val Pro Pro Ala Ala Ala Ala Asn His His His His His 
                325                 330                 335     


His His Ala Leu His Glu Ala Pro Lys Phe Xaa Val Glu Xaa Leu Glu 
            340                 345                 350         


His Xaa Val Asn Asn Asp Ser Glu Ile Trp Gly Leu Leu Gln Pro Tyr 
        355                 360                 365             


Gln His Leu Ile Cys Gly Lys Asn Ala Ser Gly Val Leu Cys Leu Pro 
    370                 375                 380                 


Asp Ser Leu Asn Leu His Arg Asp Pro Gln Arg Ser Asn Lys Pro Gly 
385                 390                 395                 400 


Glu Leu Pro Met Phe Ser Gln Ser Glu Leu Arg Xaa Ile Glu Gln Ser 
                405                 410                 415     


Leu Leu Ala Xaa Arg Val Gly Ser Ile Ala Glu Leu Ser Asp Leu Val 
            420                 425                 430         


Ser Arg Ala Met His His Leu Gln Pro Leu Asn Ala Lys His His Gly 
        435                 440                 445             


Asn Gly Xaa Pro Leu His His Lys Gln Gly Ala Leu Tyr Trp Glu Pro 
    450                 455                 460                 


Glu Ala Leu Tyr Xaa Leu Cys Tyr Phe Met His Cys Pro Gln Met Glu 
465                 470                 475                 480 


Trp Glu Asn Pro Asn Val Glu Pro Ser Lys Val Asn Leu Gln Val Glu 
                485                 490                 495     


Arg Pro Phe Leu Val Leu Pro Pro Leu Met Glu Trp Ile Arg Val Ala 
            500                 505                 510         


Val Ala His Ala Gly His Arg Arg Ser Phe Ser Met Asp Ser Asp Asp 
        515                 520                 525             


Val Arg Gln Ala Ala Arg Leu Leu Leu Pro Gly Val Asp Cys Glu Pro 
    530                 535                 540                 


Arg Gln Leu Arg Ala Asp Asp Cys Phe Cys Ala Ser Arg Lys Leu Asp 
545                 550                 555                 560 


Ala Val Ala Ile Glu Ala Lys Phe Lys Gln Asp Leu Gly Phe Arg Met 
                565                 570                 575     


Leu Asn Cys Gly Arg Xaa Asp Leu Val Lys Gln Ala Val Ser Leu Leu 
            580                 585                 590         


Gly Pro Asp Gly Ile Asn Xaa Met Ser Glu Gln Gly Met Xaa Pro Leu 
        595                 600                 605             


Met Tyr Ala Cys Val Arg Gly Asp Glu Ala Met Val Gln Met Leu Leu 
    610                 615                 620                 


Asp Ala Gly Ala Asp Leu Asn Val Glu Val Val Ser Xaa Pro His Lys 
625                 630                 635                 640 


Tyr Pro Ser Val His Pro Glu Xaa Arg His Trp Xaa Ala Leu Xaa Phe 
                645                 650                 655     


Ala Val Leu His Gly His Ile Pro Val Val Gln Leu Leu Leu Asp Ala 
            660                 665                 670         


Gly Ala Lys Val Glu Gly Ser Val Glu His Gly Glu Glu Asn Tyr Ser 
        675                 680                 685             


Glu Xaa Pro Leu Gln Leu Ala Ala Ala Val Gly Asn Phe Glu Leu Val 
    690                 695                 700                 


Ser Leu Leu Leu Glu Arg Gly Ala Asp Pro Leu Ile Gly Xaa Met Tyr 
705                 710                 715                 720 


Arg Asn Gly Ile Ser Xaa Xaa Pro Gln Gly Asp Met Asn Ser Phe Ser 
                725                 730                 735     


Gln Ala Ala Ala His Gly His Arg Asn Val Phe Arg Lys Leu Leu Ala 
            740                 745                 750         


Gln Pro Glu Lys Glu Lys Ser Asp Ile Leu Ser Leu Glu Glu Ile Leu 
        755                 760                 765             


Ala Glu Gly Xaa Asp Leu Ala Glu Xaa Ala Pro Pro Pro Leu Cys Ala 
    770                 775                 780                 


Ser Arg Asn Ser Lys Ala Lys Leu Arg Ala Leu Arg Glu Ala Met Tyr 
785                 790                 795                 800 


His Ser Ala Glu His Gly Tyr Val Asp Val Xaa Ile Asp Ile Arg Ser 
                805                 810                 815     


Ile Gly Val Pro Trp Xaa Leu His Xaa Trp Leu Glu Ser Leu Arg Ile 
            820                 825                 830         


Ala Phe Gln Gln His Arg Arg Pro Leu Ile Gln Cys Leu Leu Lys Glu 
        835                 840                 845             


Phe Lys Xaa Ile Gln Glu Glu Glu Tyr Xaa Glu Glu Leu Val Xaa Gln 
    850                 855                 860                 


Gly Leu Pro Leu Met Phe Glu Ile Leu Lys Ala Ser Lys Asn Glu Val 
865                 870                 875                 880 


Ile Ser Gln Gln Leu Cys Val Ile Phe Xaa His Cys Tyr Gly Pro Tyr 
                885                 890                 895     


Pro Ile Pro Lys Leu Xaa Glu Ile Lys Arg Lys Gln Xaa Ser Arg Leu 
            900                 905                 910         


Asp Pro His Phe Leu Asn Asn Lys Glu Met Ser Asp Val Xaa Phe Leu 
        915                 920                 925             


Val Glu Gly Arg Pro Phe Tyr Ala His Lys Val Leu Leu Phe Xaa Ala 
    930                 935                 940                 


Ser Pro Arg Phe Lys Ala Leu Leu Ser Ser Lys Pro Xaa Asn Asp Gly 
945                 950                 955                 960 


Xaa Cys Ile Glu Ile Gly Tyr Val Lys Tyr Ser Ile Phe Gln Leu Val 
                965                 970                 975     


Met Gln Tyr Leu Tyr Tyr Gly Gly Pro Glu Ser Leu Leu Ile Lys Asn 
            980                 985                 990         


Asn Glu Ile Met Glu Leu Leu Ser  Ala Ala Lys Phe Phe  Gln Leu Glu 
        995                 1000                 1005             


Ala Leu  Gln Arg His Cys Glu  Ile Ile Cys Ala Lys  Ser Ile Asn 
    1010                 1015                 1020             


Xaa Asp  Asn Cys Val Asp Ile  Tyr Asn His Ala Lys  Phe Leu Gly 
    1025                 1030                 1035             


Val Xaa  Glu Leu Ser Ala Tyr  Cys Glu Gly Tyr Phe  Leu Lys Asn 
    1040                 1045                 1050             


Met Met  Val Leu Ile Glu Asn  Glu Ala Phe Lys Gln  Leu Leu Tyr 
    1055                 1060                 1065             


Asp Lys  Asn Gly Glu Gly Xaa  Gly Gln Asp Val Leu  Gln Asp Leu 
    1070                 1075                 1080             


Gln Arg  Xaa Leu Ala Ile Arg  Ile Gln Ser Ile His  Leu Ser Ser 
    1085                 1090                 1095             


Ser Lys  Gly Ser Val Val 
    1100                 


<210> 4488
<211> 641
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<400> 4488
Met Arg Lys Leu Arg Pro Lys Asp Ser Arg Glu Pro Ala Pro Gly Ser 
1               5                   10                  15      


Pro Val Arg Ser Gly Cys Leu Gln Arg Leu Ser His Tyr Ser Gly Ile 
            20                  25                  30          


Gln Arg Pro Phe Leu Val Leu Pro Pro Leu Met Glu Trp Ile Arg Val 
        35                  40                  45              


Ala Val Ala His Ala Gly His Arg Arg Ser Phe Ser Met Asp Ser Asp 
    50                  55                  60                  


Asp Val Arg Gln Ala Ala Arg Leu Leu Leu Pro Gly Val Asp Cys Glu 
65                  70                  75                  80  


Pro Arg Gln Leu Arg Ala Asp Asp Cys Phe Cys Ala Ser Arg Lys Leu 
                85                  90                  95      


Asp Ala Val Ala Ile Glu Ala Lys Phe Lys Gln Asp Leu Gly Phe Arg 
            100                 105                 110         


Met Leu Asn Cys Gly Arg Xaa Asp Leu Val Lys Gln Ala Val Ser Leu 
        115                 120                 125             


Leu Gly Pro Asp Gly Ile Asn Xaa Met Ser Glu Gln Gly Met Xaa Pro 
    130                 135                 140                 


Leu Met Tyr Ala Cys Val Arg Gly Asp Glu Ala Met Val Gln Met Leu 
145                 150                 155                 160 


Leu Asp Ala Gly Ala Asp Leu Asn Val Glu Val Val Ser Xaa Pro His 
                165                 170                 175     


Lys Tyr Pro Ser Val His Pro Glu Xaa Arg His Trp Xaa Ala Leu Xaa 
            180                 185                 190         


Phe Ala Val Leu His Gly His Ile Pro Val Val Gln Leu Leu Leu Asp 
        195                 200                 205             


Ala Gly Ala Lys Val Glu Gly Ser Val Glu His Gly Glu Glu Asn Tyr 
    210                 215                 220                 


Ser Glu Xaa Pro Leu Gln Leu Ala Ala Ala Val Gly Asn Phe Glu Leu 
225                 230                 235                 240 


Val Ser Leu Leu Leu Glu Arg Gly Ala Asp Pro Leu Ile Gly Xaa Met 
                245                 250                 255     


Tyr Arg Asn Gly Ile Ser Xaa Xaa Pro Gln Gly Asp Met Asn Ser Phe 
            260                 265                 270         


Ser Gln Ala Ala Ala His Gly His Arg Asn Val Phe Arg Lys Leu Leu 
        275                 280                 285             


Ala Gln Pro Glu Lys Glu Lys Ser Asp Ile Leu Ser Leu Glu Glu Ile 
    290                 295                 300                 


Leu Ala Glu Gly Xaa Asp Leu Ala Glu Xaa Ala Pro Pro Pro Leu Cys 
305                 310                 315                 320 


Ala Ser Arg Asn Ser Lys Ala Lys Leu Arg Ala Leu Arg Glu Ala Met 
                325                 330                 335     


Tyr His Ser Ala Glu His Gly Tyr Val Asp Val Xaa Ile Asp Ile Arg 
            340                 345                 350         


Ser Ile Gly Val Pro Trp Xaa Leu His Xaa Trp Leu Glu Ser Leu Arg 
        355                 360                 365             


Ile Ala Phe Gln Gln His Arg Arg Pro Leu Ile Gln Cys Leu Leu Lys 
    370                 375                 380                 


Glu Phe Lys Xaa Ile Gln Glu Glu Glu Tyr Xaa Glu Glu Leu Val Xaa 
385                 390                 395                 400 


Gln Gly Leu Pro Leu Met Phe Glu Ile Leu Lys Ala Ser Lys Asn Glu 
                405                 410                 415     


Val Ile Ser Gln Gln Leu Cys Val Ile Phe Xaa His Cys Tyr Gly Pro 
            420                 425                 430         


Tyr Pro Ile Pro Lys Leu Xaa Glu Ile Lys Arg Lys Gln Xaa Ser Arg 
        435                 440                 445             


Leu Asp Pro His Phe Leu Asn Asn Lys Glu Met Ser Asp Val Xaa Phe 
    450                 455                 460                 


Leu Val Glu Gly Arg Pro Phe Tyr Ala His Lys Val Leu Leu Phe Xaa 
465                 470                 475                 480 


Ala Ser Pro Arg Phe Lys Ala Leu Leu Ser Ser Lys Pro Xaa Asn Asp 
                485                 490                 495     


Gly Xaa Cys Ile Glu Ile Gly Tyr Val Lys Tyr Ser Ile Phe Gln Leu 
            500                 505                 510         


Val Met Gln Tyr Leu Tyr Tyr Gly Gly Pro Glu Ser Leu Leu Ile Lys 
        515                 520                 525             


Asn Asn Glu Ile Met Glu Leu Leu Ser Ala Ala Lys Phe Phe Gln Leu 
    530                 535                 540                 


Glu Ala Leu Gln Arg His Cys Glu Ile Ile Cys Ala Lys Ser Ile Asn 
545                 550                 555                 560 


Xaa Asp Asn Cys Val Asp Ile Tyr Asn His Ala Lys Phe Leu Gly Val 
                565                 570                 575     


Xaa Glu Leu Ser Ala Tyr Cys Glu Gly Tyr Phe Leu Lys Asn Met Met 
            580                 585                 590         


Val Leu Ile Glu Asn Glu Ala Phe Lys Gln Leu Leu Tyr Asp Lys Asn 
        595                 600                 605             


Gly Glu Gly Xaa Gly Gln Asp Val Leu Gln Asp Leu Gln Arg Xaa Leu 
    610                 615                 620                 


Ala Ile Arg Ile Gln Ser Ile His Leu Ser Ser Ser Lys Gly Ser Val 
625                 630                 635                 640 


Val 
    


<210> 4489
<211> 183
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 4489
Met Ser Asp Val Xaa Phe Leu Val Glu Gly Arg Pro Phe Tyr Ala His 
1               5                   10                  15      


Lys Val Leu Leu Phe Xaa Ala Ser Pro Arg Phe Lys Ala Leu Leu Ser 
            20                  25                  30          


Ser Lys Pro Xaa Asn Asp Gly Xaa Cys Ile Glu Ile Gly Tyr Val Lys 
        35                  40                  45              


Tyr Ser Ile Phe Gln Leu Val Met Gln Tyr Leu Tyr Tyr Gly Gly Pro 
    50                  55                  60                  


Glu Ser Leu Leu Ile Lys Asn Asn Glu Ile Met Glu Leu Leu Ser Ala 
65                  70                  75                  80  


Ala Lys Phe Phe Gln Leu Glu Ala Leu Gln Arg His Cys Glu Ile Ile 
                85                  90                  95      


Cys Ala Lys Ser Ile Asn Xaa Asp Asn Cys Val Asp Ile Tyr Asn His 
            100                 105                 110         


Ala Lys Phe Leu Gly Val Xaa Glu Leu Ser Ala Tyr Cys Glu Gly Tyr 
        115                 120                 125             


Phe Leu Lys Asn Met Met Val Leu Ile Glu Asn Glu Ala Phe Lys Gln 
    130                 135                 140                 


Leu Leu Tyr Asp Lys Asn Gly Glu Gly Xaa Gly Gln Asp Val Leu Gln 
145                 150                 155                 160 


Asp Leu Gln Arg Xaa Leu Ala Ile Arg Ile Gln Ser Ile His Leu Ser 
                165                 170                 175     


Ser Ser Lys Gly Ser Val Val 
            180             


<210> 4490
<211> 237
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<400> 4490
Met Val Glu Ser Leu His Gly Leu Asp Ser Arg Lys Gly Val Leu Cys 
1               5                   10                  15      


Leu Pro Asp Ser Leu Asn Leu His Arg Asp Pro Gln Arg Ser Asn Lys 
            20                  25                  30          


Pro Gly Glu Leu Pro Met Phe Ser Gln Ser Glu Leu Arg Xaa Ile Glu 
        35                  40                  45              


Gln Ser Leu Leu Ala Xaa Arg Val Gly Ser Ile Ala Glu Leu Ser Asp 
    50                  55                  60                  


Leu Val Ser Arg Ala Met His His Leu Gln Pro Leu Asn Ala Lys His 
65                  70                  75                  80  


His Gly Asn Gly Xaa Pro Leu His His Lys Gln Gly Ala Leu Tyr Trp 
                85                  90                  95      


Glu Pro Glu Ala Leu Tyr Xaa Leu Cys Tyr Phe Met His Cys Pro Gln 
            100                 105                 110         


Met Glu Trp Glu Asn Pro Asn Val Glu Pro Ser Lys Val Asn Leu Gln 
        115                 120                 125             


Val Glu Arg Pro Phe Leu Val Leu Pro Pro Leu Met Glu Trp Ile Arg 
    130                 135                 140                 


Val Ala Val Ala His Ala Gly His Arg Arg Ser Phe Ser Met Asp Ser 
145                 150                 155                 160 


Asp Asp Val Arg Gln Ala Ala Arg Leu Leu Leu Pro Gly Val Asp Cys 
                165                 170                 175     


Glu Pro Arg Gln Leu Arg Ala Asp Asp Cys Phe Cys Ala Ser Arg Lys 
            180                 185                 190         


Leu Asp Ala Val Ala Ile Glu Ala Lys Phe Lys Gln Asp Leu Gly Phe 
        195                 200                 205             


Arg Met Leu Asn Cys Gly Arg Xaa Asp Leu Val Lys Gln Ala Val Ser 
    210                 215                 220                 


Leu Leu Gly Pro Asp Gly Ile Asn Xaa Met Ser Glu Gln 
225                 230                 235         


<210> 4491
<211> 283
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<400> 4491
Met Ala Arg Cys Gly Glu Gly Ser Ala Ala Pro Met Val Leu Leu Gly 
1               5                   10                  15      


Ser Ala Gly Val Cys Ser Lys Gly Leu Gln Arg Lys Gly Pro Cys Glu 
            20                  25                  30          


Arg Arg Arg Leu Lys Ala Xaa Val Ser Glu Gln Leu Ser Gln Asp Leu 
        35                  40                  45              


Leu Arg Leu Leu Arg Glu Glu Phe His Xaa Asp Val Xaa Phe Ser Val 
    50                  55                  60                  


Gly Cys Xaa Leu Phe Lys Ala His Lys Ala Val Leu Leu Ala Arg Val 
65                  70                  75                  80  


Pro Asp Phe Tyr Phe His Xaa Ile Gly Gln Xaa Ser Asn Ser Leu Xaa 
                85                  90                  95      


Asn Gln Glu Pro Ile Ala Val Glu Asn Val Glu Ala Leu Glu Phe Arg 
            100                 105                 110         


Xaa Phe Leu Gln Ile Ile Tyr Ser Ser Asn Arg Asn Ile Lys Asn Tyr 
        115                 120                 125             


Glu Glu Glu Ile Leu Arg Lys Lys Ile Met Glu Ile Gly Ile Ser Gln 
    130                 135                 140                 


Lys Gln Leu Asp Ile Ser Phe Pro Lys Cys Glu Asn Ser Ser Asp Cys 
145                 150                 155                 160 


Ser Leu Gln Lys His Glu Ile Pro Glu Asp Ile Ser Asp Arg Asp Asp 
                165                 170                 175     


Asp Phe Ile Ser Asn Asp Asn Tyr Asp Leu Glu Pro Ala Ser Glu Leu 
            180                 185                 190         


Gly Glu Asp Leu Leu Lys Leu Tyr Val Lys Pro Cys Cys Pro Asp Ile 
        195                 200                 205             


Asp Ile Phe Val Asp Gly Lys Arg Phe Lys Ala His Arg Ala Ile Leu 
    210                 215                 220                 


Ser Ala Arg Ser Ser Tyr Phe Ala Ala Met Leu Ser Gly Cys Trp Ala 
225                 230                 235                 240 


Glu Ser Ser Gln Glu Tyr Val Xaa Leu Gln Gly Ile Ser His Val Glu 
                245                 250                 255     


Leu Asn Val Met Met His Phe Ile Tyr Gly Gly Xaa Leu Asp Ile Pro 
            260                 265                 270         


Asp Lys Xaa Asn Val Gly Leu Phe Pro Glu His 
        275                 280             


<210> 4492
<211> 378
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<400> 4492
Met Ala Arg Cys Gly Glu Gly Ser Ala Ala Pro Met Val Leu Leu Gly 
1               5                   10                  15      


Ser Ala Gly Val Cys Ser Lys Gly Leu Gln Arg Lys Gly Pro Cys Glu 
            20                  25                  30          


Arg Arg Arg Leu Lys Ala Xaa Val Ser Glu Gln Leu Ser Gln Asp Leu 
        35                  40                  45              


Leu Arg Leu Leu Arg Glu Glu Phe His Xaa Asp Val Xaa Phe Ser Val 
    50                  55                  60                  


Gly Cys Xaa Leu Phe Lys Ala His Lys Ala Val Leu Leu Ala Arg Val 
65                  70                  75                  80  


Pro Asp Phe Tyr Phe His Xaa Ile Gly Gln Xaa Ser Asn Ser Leu Xaa 
                85                  90                  95      


Asn Gln Glu Pro Ile Ala Val Glu Asn Val Glu Ala Leu Glu Phe Arg 
            100                 105                 110         


Xaa Phe Leu Gln Ile Ile Tyr Ser Ser Asn Arg Asn Ile Lys Asn Tyr 
        115                 120                 125             


Glu Glu Glu Ile Leu Arg Lys Lys Ile Met Glu Ile Gly Ile Ser Gln 
    130                 135                 140                 


Lys Gln Leu Asp Ile Ser Phe Pro Lys Cys Glu Asn Ser Ser Asp Cys 
145                 150                 155                 160 


Ser Leu Gln Lys His Glu Ile Pro Glu Asp Ile Ser Asp Arg Asp Asp 
                165                 170                 175     


Asp Phe Ile Ser Asn Asp Asn Tyr Asp Leu Glu Pro Ala Ser Glu Leu 
            180                 185                 190         


Gly Glu Asp Leu Leu Lys Leu Tyr Val Lys Pro Cys Cys Pro Asp Ile 
        195                 200                 205             


Asp Ile Phe Val Asp Gly Lys Arg Phe Lys Ala His Arg Ala Ile Leu 
    210                 215                 220                 


Ser Ala Arg Ser Ser Tyr Phe Ala Ala Met Leu Ser Gly Cys Trp Ala 
225                 230                 235                 240 


Glu Ser Ser Gln Glu Tyr Val Xaa Leu Gln Gly Ile Ser His Val Glu 
                245                 250                 255     


Leu Asn Val Met Met His Phe Ile Tyr Gly Gly Xaa Leu Asp Ile Pro 
            260                 265                 270         


Asp Lys Xaa Asn Val Gly Gln Ile Leu Asn Met Ala Asp Met Tyr Gly 
        275                 280                 285             


Leu Glu Gly Leu Lys Glu Val Ala Ile Tyr Ile Leu Arg Arg Asp Tyr 
    290                 295                 300                 


Cys Asn Phe Phe Gln Lys Pro Val Pro Arg Xaa Leu Xaa Ser Ile Leu 
305                 310                 315                 320 


Glu Cys Leu Ile Ile Ala His Ser Val Gly Val Glu Ser Leu Phe Ala 
                325                 330                 335     


Asp Cys Met Lys Trp Ile Val Lys His Phe Ala Arg Phe Trp Ser Glu 
            340                 345                 350         


Arg Ser Phe Ala Asn Ile Pro Pro Glu Ile Gln Lys Ser Cys Leu Asn 
        355                 360                 365             


Met Leu Ile Gln Ser Leu Val Ser Ile Xaa 
    370                 375             


<210> 4493
<211> 1792
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1226)..(1226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1252)..(1252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1304)..(1304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1306)..(1306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1421)..(1421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1431)..(1431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1533)..(1533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1538)..(1538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1603)..(1603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1626)..(1628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1645)..(1645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1649)..(1649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1659)..(1659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1680)..(1680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1683)..(1683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1699)..(1699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1715)..(1715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1732)..(1732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1746)..(1746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1750)..(1750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1758)..(1758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1768)..(1768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1784)..(1784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<400> 4493
Met Ala Arg Cys Gly Glu Gly Ser Ala Ala Pro Met Val Leu Leu Gly 
1               5                   10                  15      


Ser Ala Gly Val Cys Ser Lys Gly Leu Gln Arg Lys Gly Pro Cys Glu 
            20                  25                  30          


Arg Arg Arg Leu Lys Ala Xaa Val Ser Glu Gln Leu Ser Gln Asp Leu 
        35                  40                  45              


Leu Arg Leu Leu Arg Glu Glu Phe His Xaa Asp Val Xaa Phe Ser Val 
    50                  55                  60                  


Gly Cys Xaa Leu Phe Lys Ala His Lys Ala Val Leu Leu Ala Arg Val 
65                  70                  75                  80  


Pro Asp Phe Tyr Phe His Xaa Ile Gly Gln Xaa Ser Asn Ser Leu Xaa 
                85                  90                  95      


Asn Gln Glu Pro Ile Ala Val Glu Asn Val Glu Ala Leu Glu Phe Arg 
            100                 105                 110         


Xaa Phe Leu Gln Ile Ile Tyr Ser Ser Asn Arg Asn Ile Lys Asn Tyr 
        115                 120                 125             


Glu Glu Glu Ile Leu Arg Lys Lys Ile Met Glu Ile Gly Ile Ser Gln 
    130                 135                 140                 


Lys Gln Leu Asp Ile Ser Phe Pro Lys Cys Glu Asn Ser Ser Asp Cys 
145                 150                 155                 160 


Ser Leu Gln Lys His Glu Ile Pro Glu Asp Ile Ser Asp Arg Asp Asp 
                165                 170                 175     


Asp Phe Ile Ser Asn Asp Asn Tyr Asp Leu Glu Pro Ala Ser Glu Leu 
            180                 185                 190         


Gly Glu Asp Leu Leu Lys Leu Tyr Val Lys Pro Cys Cys Pro Asp Ile 
        195                 200                 205             


Asp Ile Phe Val Asp Gly Lys Arg Phe Lys Ala His Arg Ala Ile Leu 
    210                 215                 220                 


Ser Ala Arg Ser Ser Tyr Phe Ala Ala Met Leu Ser Gly Cys Trp Ala 
225                 230                 235                 240 


Glu Ser Ser Gln Glu Tyr Val Xaa Leu Gln Gly Ile Ser His Val Glu 
                245                 250                 255     


Leu Asn Val Met Met His Phe Ile Tyr Gly Gly Xaa Leu Asp Ile Pro 
            260                 265                 270         


Asp Lys Xaa Asn Val Gly Gln Ile Leu Asn Met Ala Asp Met Tyr Gly 
        275                 280                 285             


Leu Glu Gly Leu Lys Glu Val Ala Ile Tyr Ile Leu Arg Arg Asp Tyr 
    290                 295                 300                 


Cys Asn Phe Phe Gln Lys Pro Val Pro Arg Xaa Leu Xaa Ser Ile Leu 
305                 310                 315                 320 


Glu Cys Leu Ile Ile Ala His Ser Val Gly Val Glu Ser Leu Phe Ala 
                325                 330                 335     


Asp Cys Met Lys Trp Ile Val Lys His Phe Ala Arg Phe Trp Ser Glu 
            340                 345                 350         


Arg Ser Phe Ala Asn Ile Pro Pro Glu Ile Gln Lys Ser Cys Leu Asn 
        355                 360                 365             


Met Leu Ile Gln Ser Leu Asn Asp Lys Asn Ala Ala Phe Leu Leu Met 
    370                 375                 380                 


Glu Ser Asp Arg Leu Ile Ile Ser Leu Pro Arg Val Lys Trp Xaa Glu 
385                 390                 395                 400 


Ala Ala Leu Xaa Met Ala Ser Gln Leu Gln Glu Lys Cys Ile Ala Phe 
                405                 410                 415     


Ile Val Asp Asn Phe Ser Lys Ile Ile Gln Ser Glu Asn Phe Ala Leu 
            420                 425                 430         


Leu Leu Gln Ser Gln Ala Met Ser Ser Xaa Ala Asp Leu Leu Asp Xaa 
        435                 440                 445             


Ile Leu Lys Ala Ile Glu Glu Asn Ile Xaa Xaa Glu Asn Ser Cys Ser 
    450                 455                 460                 


Leu Leu Met Ala Leu Asp Xaa Leu Leu Asn Ser Asp Ser Xaa Lys Glu 
465                 470                 475                 480 


Met Gly Phe Xaa Cys Lys Ile Gln Ala Leu Arg Asp Lys Leu Trp Ile 
                485                 490                 495     


Phe Leu Val Gln Ser Phe Tyr Ala Val Arg His Xaa Glu Ser Trp Lys 
            500                 505                 510         


Leu Met Ser Xaa Asp Asp Gln Gln Lys Ile Gln Ala Ala Ala Phe Asp 
        515                 520                 525             


Lys Gly Asp Asp Arg Arg Leu Gly Lys Lys Pro Ile Phe Ser Ser Ser 
    530                 535                 540                 


Gln Gln Arg Lys Gln Val Ser Asp Ser Gly Asp Ile Lys Ile Lys Ser 
545                 550                 555                 560 


Trp Arg Gly Asn Asn Lys Lys Glu Cys Trp Ser Tyr Leu Ser Xaa Asn 
                565                 570                 575     


Lys Lys Met Lys Ser Asp Gly Leu Gly Ala Ser Gly His Ser Ser Ser 
            580                 585                 590         


Xaa Asn Arg Asn Ser Ile Asn Lys Xaa Leu Lys Gln Asp Asp Val Lys 
        595                 600                 605             


Glu Lys Asp Gly Xaa Lys Ile Ala Ser Lys Ile Xaa Lys Glu Leu Lys 
    610                 615                 620                 


Xaa Gly Gly Lys Asn Val Ser Gly Lys Pro Lys Xaa Val Xaa Lys Ser 
625                 630                 635                 640 


Lys Xaa Glu Asn Gly Asp Lys Ala Arg Leu Glu Asn Met Ser Pro Arg 
                645                 650                 655     


Gln Val Val Glu Arg Ser Ala Xaa Ala Ala Ala Ala Ala Xaa Gly Gln 
            660                 665                 670         


Lys Asn Leu Leu Asn Gly Lys Gly Val Arg Asn Gln Glu Gly Gln Ile 
        675                 680                 685             


Ser Gly Ala Arg Pro Lys Val Leu Xaa Gly Asn Leu Asn Val Gln Ala 
    690                 695                 700                 


Lys Ala Lys Pro Leu Lys Lys Ala Xaa Gly Lys Asp Ser Pro Cys Leu 
705                 710                 715                 720 


Ser Ile Ala Gly Pro Ser Ser Arg Ser Xaa Asp Ser Ser Met Glu Phe 
                725                 730                 735     


Ser Ile Ser Xaa Glu Cys Leu Asp Glu Pro Lys Glu Asn Gly Ser Xaa 
            740                 745                 750         


Glu Glu Glu Lys Pro Ser Gly His Lys Leu Ser Phe Cys Asp Ser Pro 
        755                 760                 765             


Gly Gln Met Met Lys Asn Ser Val Asp Ser Val Lys Asn Ser Xaa Val 
    770                 775                 780                 


Ala Ile Lys Ser Arg Pro Val Ser Arg Val Xaa Asn Gly Xaa Ser Asn 
785                 790                 795                 800 


Lys Lys Ser Ile His Glu Gln Asp Xaa Asn Val Asn Asn Ser Val Leu 
                805                 810                 815     


Lys Lys Val Ser Gly Lys Gly Cys Ser Glu Pro Val Pro Gln Ala Ile 
            820                 825                 830         


Leu Lys Lys Arg Gly Xaa Ser Asn Gly Cys Xaa Ala Ala Gln Gln Arg 
        835                 840                 845             


Xaa Lys Ser Xaa Pro Ser Asn Leu Xaa Lys Xaa Gln Gly Ser Gln Gly 
    850                 855                 860                 


Glu Ser Pro Asn Ser Val Lys Ser Ser Val Ser Ser Arg Gln Ser Asp 
865                 870                 875                 880 


Glu Asn Val Ala Lys Leu Asp His Asn Xaa Xaa Xaa Glu Lys Gln Ala 
                885                 890                 895     


Pro Lys Arg Lys Met Val Lys Gln Val His Xaa Ala Leu Pro Lys Val 
            900                 905                 910         


Asn Ala Lys Ile Val Ala Met Pro Lys Asn Leu Asn Gln Ser Lys Lys 
        915                 920                 925             


Gly Glu Xaa Leu Asn Asn Lys Asp Ser Lys Gln Lys Met Pro Pro Gly 
    930                 935                 940                 


Gln Val Ile Ser Lys Xaa Gln Pro Ser Ser Gln Arg Pro Leu Lys His 
945                 950                 955                 960 


Glu Xaa Ser Xaa Val Gln Lys Ser Met Phe His Asp Val Arg Asp Asn 
                965                 970                 975     


Asn Asn Lys Asp Ser Val Ser Glu Gln Lys Pro His Lys Pro Leu Ile 
            980                 985                 990         


Asn Leu Ala Ser Glu Ile Ser Asp  Ala Glu Ala Leu Gln  Ser Ser Cys 
        995                 1000                 1005             


Arg Pro  Asp Pro Gln Lys Pro  Leu Asn Asp Gln Glu  Lys Glu Lys 
    1010                 1015                 1020             


Leu Ala  Leu Glu Cys Gln Asn  Ile Ser Lys Leu Asp  Lys Ser Leu 
    1025                 1030                 1035             


Lys His  Glu Leu Glu Ser Lys  Gln Ile Cys Leu Asp  Lys Ser Glu 
    1040                 1045                 1050             


Xaa Lys  Phe Pro Asn His Lys  Glu Xaa Asp Asp Cys  Asp Ala Ala 
    1055                 1060                 1065             


Asn Ile  Cys Cys His Ser Val  Gly Ser Asp Asn Val  Asn Ser Lys 
    1070                 1075                 1080             


Phe Tyr  Ser Xaa Xaa Ala Leu  Lys Tyr Met Val Ser  Asn Pro Asn 
    1085                 1090                 1095             


Glu Asn  Ser Leu Asn Ser Asn  Pro Val Cys Asp Leu  Asp Ser Xaa 
    1100                 1105                 1110             


Ser Ala  Gly Gln Ile His Leu  Ile Ser Asp Arg Glu  Asn Gln Val 
    1115                 1120                 1125             


Gly Arg  Lys Asp Xaa Asn Lys  Gln Ser Ser Ile Lys  Cys Val Glu 
    1130                 1135                 1140             


Asp Val  Ser Leu Cys Asn Pro  Glu Arg Xaa Asn Gly  Xaa Leu Asn 
    1145                 1150                 1155             


Ser Ala  Gln Glu Asp Lys Lys  Ser Lys Val Pro Val  Glu Gly Leu 
    1160                 1165                 1170             


Xaa Ile  Pro Ser Lys Leu Ser  Asp Glu Ser Ala Met  Asp Glu Asp 
    1175                 1180                 1185             


Lys His  Ala Xaa Ala Asp Ser  Asp Val Ser Ser Lys  Cys Phe Ser 
    1190                 1195                 1200             


Gly Gln  Leu Ser Glu Lys Asn  Ser Pro Lys Asn Met  Glu Xaa Ser 
    1205                 1210                 1215             


Glu Ser  Pro Glu Ser His Glu  Xaa Pro Glu Xaa Pro  Phe Val Gly 
    1220                 1225                 1230             


His Trp  Asn Leu Ser Xaa Gly  Val Leu His Gln Arg  Glu Ser Pro 
    1235                 1240                 1245             


Glu Ser  Asp Xaa Gly Ser Ala  Xaa Xaa Ser Ser Asp  Asp Ile Lys 
    1250                 1255                 1260             


Pro Arg  Ser Glu Asp Tyr Asp  Ala Gly Gly Ser Gln  Asp Asp Asp 
    1265                 1270                 1275             


Gly Ser  Asn Asp Arg Gly Ile  Ser Lys Cys Gly Xaa  Met Leu Cys 
    1280                 1285                 1290             


His Asp  Phe Leu Gly Arg Ser  Ser Ser Asp Xaa Ser  Xaa Pro Glu 
    1295                 1300                 1305             


Glu Leu  Lys Ile Tyr Asp Ser  Asn Leu Arg Ile Glu  Val Lys Met 
    1310                 1315                 1320             


Lys Lys  Gln Ser Asn Asn Asp  Leu Phe Gln Val Asn  Ser Xaa Ser 
    1325                 1330                 1335             


Asp Asp  Glu Ile Pro Arg Lys  Arg Pro Glu Ile Trp  Ser Arg Ser 
    1340                 1345                 1350             


Ala Ile  Val His Ser Arg Glu  Arg Glu Asn Ile Pro  Arg Gly Ser 
    1355                 1360                 1365             


Val Gln  Phe Ala Gln Glu Ile  Asp Gln Val Ser Ser  Ser Ala Asp 
    1370                 1375                 1380             


Glu Xaa  Glu Asp Glu Arg Ser  Glu Ala Glu Asn Val  Ala Glu Asn 
    1385                 1390                 1395             


Phe Ser  Ile Ser Asn Pro Ala  Pro Gln Gln Phe Gln  Gly Ile Ile 
    1400                 1405                 1410             


Asn Leu  Ala Phe Glu Asp Ala  Xaa Glu Asn Glu Cys  Arg Glu Phe 
    1415                 1420                 1425             


Ser Ala  Xaa Lys Lys Phe Lys  Arg Ser Val Leu Leu  Ser Val Asp 
    1430                 1435                 1440             


Glu Cys  Glu Glu Leu Gly Ser  Asp Glu Gly Glu Val  His Xaa Pro 
    1445                 1450                 1455             


Phe Gln  Ala Ser Val Asp Ser  Phe Ser Pro Ser Asp  Val Phe Asp 
    1460                 1465                 1470             


Gly Ile  Ser His Glu His His  Gly Arg Xaa Cys Tyr  Ser Arg Phe 
    1475                 1480                 1485             


Ser Arg  Glu Ser Glu Asp Asn  Ile Leu Glu Cys Lys  Gln Asn Lys 
    1490                 1495                 1500             


Gly Asn  Ser Val Cys Lys Asn  Glu Ser Xaa Val Leu  Asp Leu Ser 
    1505                 1510                 1515             


Ser Ile  Asp Ser Ser Arg Lys  Asn Lys Gln Ser Val  Ser Ala Xaa 
    1520                 1525                 1530             


Glu Lys  Lys Asn Xaa Ile Asp  Val Leu Ser Ser Arg  Ser Arg Gln 
    1535                 1540                 1545             


Leu Leu  Arg Glu Asp Lys Lys  Val Asn Asn Gly Ser  Asn Val Glu 
    1550                 1555                 1560             


Asn Asp  Ile Gln Gln Arg Ser  Lys Phe Leu Asp Ser  Asp Val Lys 
    1565                 1570                 1575             


Ser Gln  Glu Arg Pro Cys His  Leu Asp Leu His Gln  Arg Glu Pro 
    1580                 1585                 1590             


Asn Ser  Asp Ile Pro Lys Asn  Ser Ser Xaa Lys Ser  Leu Asp Ser 
    1595                 1600                 1605             


Phe Arg  Ser Gln Val Leu Pro  Gln Glu Gly Pro Val  Lys Glu Ser 
    1610                 1615                 1620             


His Ser  Xaa Xaa Xaa Glu Lys  Ala Asn Ile Ala Leu  Ser Ala Gly 
    1625                 1630                 1635             


Asp Ile  Asp Asp Cys Asp Xaa  Leu Ala Gln Xaa Arg  Met Tyr Asp 
    1640                 1645                 1650             


His Arg  Pro Ser Lys Xaa Leu  Ser Pro Ile Tyr Glu  Met Asp Val 
    1655                 1660                 1665             


Ile Glu  Ala Phe Glu Gln Lys  Val Glu Ser Glu Xaa  His Val Xaa 
    1670                 1675                 1680             


Asp Met  Asp Phe Glu Asp Asp  Gln His Phe Ala Lys  Gln Asp Trp 
    1685                 1690                 1695             


Xaa Leu  Leu Lys Gln Leu Leu  Ser Glu Gln Asp Ser  Asn Leu Asp 
    1700                 1705                 1710             


Val Xaa  Asn Ser Val Pro Glu  Asp Leu Ser Leu Ala  Gln Tyr Leu 
    1715                 1720                 1725             


Ile Asn  Gln Xaa Leu Leu Leu  Ala Arg Asp Ser Ser  Lys Pro Gln 
    1730                 1735                 1740             


Gly Ile  Xaa His Ile Asp Xaa  Leu Asn Arg Trp Ser  Glu Leu Xaa 
    1745                 1750                 1755             


Ser Pro  Leu Asp Ser Ser Ala  Ser Ile Xaa Met Ala  Ser Phe Ser 
    1760                 1765                 1770             


Ser Glu  Asp Cys Ser Pro Gln  Gly Glu Trp Xaa Ile  Leu Glu Leu 
    1775                 1780                 1785             


Glu Xaa  Gln His 
    1790         


<210> 4494
<211> 1409
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (873)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1243)..(1245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1262)..(1262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1276)..(1276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1297)..(1297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1300)..(1300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1316)..(1316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1349)..(1349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1363)..(1363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1367)..(1367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1375)..(1375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1407)
<223> Selenocysteine

<400> 4494
Met Glu Ser Asp Arg Leu Ile Ile Ser Leu Pro Arg Val Lys Trp Xaa 
1               5                   10                  15      


Glu Ala Ala Leu Xaa Met Ala Ser Gln Leu Gln Glu Lys Cys Ile Ala 
            20                  25                  30          


Phe Ile Val Asp Asn Phe Ser Lys Ile Ile Gln Ser Glu Asn Phe Ala 
        35                  40                  45              


Leu Leu Leu Gln Ser Gln Ala Met Ser Ser Xaa Ala Asp Leu Leu Asp 
    50                  55                  60                  


Xaa Ile Leu Lys Ala Ile Glu Glu Asn Ile Xaa Xaa Glu Asn Ser Cys 
65                  70                  75                  80  


Ser Leu Leu Met Ala Leu Asp Xaa Leu Leu Asn Ser Asp Ser Xaa Lys 
                85                  90                  95      


Glu Met Gly Phe Xaa Cys Lys Ile Gln Ala Leu Arg Asp Lys Leu Trp 
            100                 105                 110         


Ile Phe Leu Val Gln Ser Phe Tyr Ala Val Arg His Xaa Glu Ser Trp 
        115                 120                 125             


Lys Leu Met Ser Xaa Asp Asp Gln Gln Lys Ile Gln Ala Ala Ala Phe 
    130                 135                 140                 


Asp Lys Gly Asp Asp Arg Arg Leu Gly Lys Lys Pro Ile Phe Ser Ser 
145                 150                 155                 160 


Ser Gln Gln Arg Lys Gln Val Ser Asp Ser Gly Asp Ile Lys Ile Lys 
                165                 170                 175     


Ser Trp Arg Gly Asn Asn Lys Lys Glu Cys Trp Ser Tyr Leu Ser Xaa 
            180                 185                 190         


Asn Lys Lys Met Lys Ser Asp Gly Leu Gly Ala Ser Gly His Ser Ser 
        195                 200                 205             


Ser Xaa Asn Arg Asn Ser Ile Asn Lys Xaa Leu Lys Gln Asp Asp Val 
    210                 215                 220                 


Lys Glu Lys Asp Gly Xaa Lys Ile Ala Ser Lys Ile Xaa Lys Glu Leu 
225                 230                 235                 240 


Lys Xaa Gly Gly Lys Asn Val Ser Gly Lys Pro Lys Xaa Val Xaa Lys 
                245                 250                 255     


Ser Lys Xaa Glu Asn Gly Asp Lys Ala Arg Leu Glu Asn Met Ser Pro 
            260                 265                 270         


Arg Gln Val Val Glu Arg Ser Ala Xaa Ala Ala Ala Ala Ala Xaa Gly 
        275                 280                 285             


Gln Lys Asn Leu Leu Asn Gly Lys Gly Val Arg Asn Gln Glu Gly Gln 
    290                 295                 300                 


Ile Ser Gly Ala Arg Pro Lys Val Leu Xaa Gly Asn Leu Asn Val Gln 
305                 310                 315                 320 


Ala Lys Ala Lys Pro Leu Lys Lys Ala Xaa Gly Lys Asp Ser Pro Cys 
                325                 330                 335     


Leu Ser Ile Ala Gly Pro Ser Ser Arg Ser Xaa Asp Ser Ser Met Glu 
            340                 345                 350         


Phe Ser Ile Ser Xaa Glu Cys Leu Asp Glu Pro Lys Glu Asn Gly Ser 
        355                 360                 365             


Xaa Glu Glu Glu Lys Pro Ser Gly His Lys Leu Ser Phe Cys Asp Ser 
    370                 375                 380                 


Pro Gly Gln Met Met Lys Asn Ser Val Asp Ser Val Lys Asn Ser Xaa 
385                 390                 395                 400 


Val Ala Ile Lys Ser Arg Pro Val Ser Arg Val Xaa Asn Gly Xaa Ser 
                405                 410                 415     


Asn Lys Lys Ser Ile His Glu Gln Asp Xaa Asn Val Asn Asn Ser Val 
            420                 425                 430         


Leu Lys Lys Val Ser Gly Lys Gly Cys Ser Glu Pro Val Pro Gln Ala 
        435                 440                 445             


Ile Leu Lys Lys Arg Gly Xaa Ser Asn Gly Cys Xaa Ala Ala Gln Gln 
    450                 455                 460                 


Arg Xaa Lys Ser Xaa Pro Ser Asn Leu Xaa Lys Xaa Gln Gly Ser Gln 
465                 470                 475                 480 


Gly Glu Ser Pro Asn Ser Val Lys Ser Ser Val Ser Ser Arg Gln Ser 
                485                 490                 495     


Asp Glu Asn Val Ala Lys Leu Asp His Asn Xaa Xaa Xaa Glu Lys Gln 
            500                 505                 510         


Ala Pro Lys Arg Lys Met Val Lys Gln Val His Xaa Ala Leu Pro Lys 
        515                 520                 525             


Val Asn Ala Lys Ile Val Ala Met Pro Lys Asn Leu Asn Gln Ser Lys 
    530                 535                 540                 


Lys Gly Glu Xaa Leu Asn Asn Lys Asp Ser Lys Gln Lys Met Pro Pro 
545                 550                 555                 560 


Gly Gln Val Ile Ser Lys Xaa Gln Pro Ser Ser Gln Arg Pro Leu Lys 
                565                 570                 575     


His Glu Xaa Ser Xaa Val Gln Lys Ser Met Phe His Asp Val Arg Asp 
            580                 585                 590         


Asn Asn Asn Lys Asp Ser Val Ser Glu Gln Lys Pro His Lys Pro Leu 
        595                 600                 605             


Ile Asn Leu Ala Ser Glu Ile Ser Asp Ala Glu Ala Leu Gln Ser Ser 
    610                 615                 620                 


Cys Arg Pro Asp Pro Gln Lys Pro Leu Asn Asp Gln Glu Lys Glu Lys 
625                 630                 635                 640 


Leu Ala Leu Glu Cys Gln Asn Ile Ser Lys Leu Asp Lys Ser Leu Lys 
                645                 650                 655     


His Glu Leu Glu Ser Lys Gln Ile Cys Leu Asp Lys Ser Glu Xaa Lys 
            660                 665                 670         


Phe Pro Asn His Lys Glu Xaa Asp Asp Cys Asp Ala Ala Asn Ile Cys 
        675                 680                 685             


Cys His Ser Val Gly Ser Asp Asn Val Asn Ser Lys Phe Tyr Ser Xaa 
    690                 695                 700                 


Xaa Ala Leu Lys Tyr Met Val Ser Asn Pro Asn Glu Asn Ser Leu Asn 
705                 710                 715                 720 


Ser Asn Pro Val Cys Asp Leu Asp Ser Xaa Ser Ala Gly Gln Ile His 
                725                 730                 735     


Leu Ile Ser Asp Arg Glu Asn Gln Val Gly Arg Lys Asp Xaa Asn Lys 
            740                 745                 750         


Gln Ser Ser Ile Lys Cys Val Glu Asp Val Ser Leu Cys Asn Pro Glu 
        755                 760                 765             


Arg Xaa Asn Gly Xaa Leu Asn Ser Ala Gln Glu Asp Lys Lys Ser Lys 
    770                 775                 780                 


Val Pro Val Glu Gly Leu Xaa Ile Pro Ser Lys Leu Ser Asp Glu Ser 
785                 790                 795                 800 


Ala Met Asp Glu Asp Lys His Ala Xaa Ala Asp Ser Asp Val Ser Ser 
                805                 810                 815     


Lys Cys Phe Ser Gly Gln Leu Ser Glu Lys Asn Ser Pro Lys Asn Met 
            820                 825                 830         


Glu Xaa Ser Glu Ser Pro Glu Ser His Glu Xaa Pro Glu Xaa Pro Phe 
        835                 840                 845             


Val Gly His Trp Asn Leu Ser Xaa Gly Val Leu His Gln Arg Glu Ser 
    850                 855                 860                 


Pro Glu Ser Asp Xaa Gly Ser Ala Xaa Xaa Ser Ser Asp Asp Ile Lys 
865                 870                 875                 880 


Pro Arg Ser Glu Asp Tyr Asp Ala Gly Gly Ser Gln Asp Asp Asp Gly 
                885                 890                 895     


Ser Asn Asp Arg Gly Ile Ser Lys Cys Gly Xaa Met Leu Cys His Asp 
            900                 905                 910         


Phe Leu Gly Arg Ser Ser Ser Asp Xaa Ser Xaa Pro Glu Glu Leu Lys 
        915                 920                 925             


Ile Tyr Asp Ser Asn Leu Arg Ile Glu Val Lys Met Lys Lys Gln Ser 
    930                 935                 940                 


Asn Asn Asp Leu Phe Gln Val Asn Ser Xaa Ser Asp Asp Glu Ile Pro 
945                 950                 955                 960 


Arg Lys Arg Pro Glu Ile Trp Ser Arg Ser Ala Ile Val His Ser Arg 
                965                 970                 975     


Glu Arg Glu Asn Ile Pro Arg Gly Ser Val Gln Phe Ala Gln Glu Ile 
            980                 985                 990         


Asp Gln Val Ser Ser Ser Ala Asp  Glu Xaa Glu Asp Glu  Arg Ser Glu 
        995                 1000                 1005             


Ala Glu  Asn Val Ala Glu Asn  Phe Ser Ile Ser Asn  Pro Ala Pro 
    1010                 1015                 1020             


Gln Gln  Phe Gln Gly Ile Ile  Asn Leu Ala Phe Glu  Asp Ala Xaa 
    1025                 1030                 1035             


Glu Asn  Glu Cys Arg Glu Phe  Ser Ala Xaa Lys Lys  Phe Lys Arg 
    1040                 1045                 1050             


Ser Val  Leu Leu Ser Val Asp  Glu Cys Glu Glu Leu  Gly Ser Asp 
    1055                 1060                 1065             


Glu Gly  Glu Val His Xaa Pro  Phe Gln Ala Ser Val  Asp Ser Phe 
    1070                 1075                 1080             


Ser Pro  Ser Asp Val Phe Asp  Gly Ile Ser His Glu  His His Gly 
    1085                 1090                 1095             


Arg Xaa  Cys Tyr Ser Arg Phe  Ser Arg Glu Ser Glu  Asp Asn Ile 
    1100                 1105                 1110             


Leu Glu  Cys Lys Gln Asn Lys  Gly Asn Ser Val Cys  Lys Asn Glu 
    1115                 1120                 1125             


Ser Xaa  Val Leu Asp Leu Ser  Ser Ile Asp Ser Ser  Arg Lys Asn 
    1130                 1135                 1140             


Lys Gln  Ser Val Ser Ala Xaa  Glu Lys Lys Asn Xaa  Ile Asp Val 
    1145                 1150                 1155             


Leu Ser  Ser Arg Ser Arg Gln  Leu Leu Arg Glu Asp  Lys Lys Val 
    1160                 1165                 1170             


Asn Asn  Gly Ser Asn Val Glu  Asn Asp Ile Gln Gln  Arg Ser Lys 
    1175                 1180                 1185             


Phe Leu  Asp Ser Asp Val Lys  Ser Gln Glu Arg Pro  Cys His Leu 
    1190                 1195                 1200             


Asp Leu  His Gln Arg Glu Pro  Asn Ser Asp Ile Pro  Lys Asn Ser 
    1205                 1210                 1215             


Ser Xaa  Lys Ser Leu Asp Ser  Phe Arg Ser Gln Val  Leu Pro Gln 
    1220                 1225                 1230             


Glu Gly  Pro Val Lys Glu Ser  His Ser Xaa Xaa Xaa  Glu Lys Ala 
    1235                 1240                 1245             


Asn Ile  Ala Leu Ser Ala Gly  Asp Ile Asp Asp Cys  Asp Xaa Leu 
    1250                 1255                 1260             


Ala Gln  Xaa Arg Met Tyr Asp  His Arg Pro Ser Lys  Xaa Leu Ser 
    1265                 1270                 1275             


Pro Ile  Tyr Glu Met Asp Val  Ile Glu Ala Phe Glu  Gln Lys Val 
    1280                 1285                 1290             


Glu Ser  Glu Xaa His Val Xaa  Asp Met Asp Phe Glu  Asp Asp Gln 
    1295                 1300                 1305             


His Phe  Ala Lys Gln Asp Trp  Xaa Leu Leu Lys Gln  Leu Leu Ser 
    1310                 1315                 1320             


Glu Gln  Asp Ser Asn Leu Asp  Val Xaa Asn Ser Val  Pro Glu Asp 
    1325                 1330                 1335             


Leu Ser  Leu Ala Gln Tyr Leu  Ile Asn Gln Xaa Leu  Leu Leu Ala 
    1340                 1345                 1350             


Arg Asp  Ser Ser Lys Pro Gln  Gly Ile Xaa His Ile  Asp Xaa Leu 
    1355                 1360                 1365             


Asn Arg  Trp Ser Glu Leu Xaa  Ser Pro Leu Asp Ser  Ser Ala Ser 
    1370                 1375                 1380             


Ile Xaa  Met Ala Ser Phe Ser  Ser Glu Asp Cys Ser  Pro Gln Gly 
    1385                 1390                 1395             


Glu Trp  Xaa Ile Leu Glu Leu  Glu Xaa Gln His 
    1400                 1405                 


<210> 4495
<211> 1279
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1237)..(1237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1245)..(1245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1255)..(1255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1277)..(1277)
<223> Selenocysteine

<400> 4495
Met Ser Xaa Asp Asp Gln Gln Lys Ile Gln Ala Ala Ala Phe Asp Lys 
1               5                   10                  15      


Gly Asp Asp Arg Arg Leu Gly Lys Lys Pro Ile Phe Ser Ser Ser Gln 
            20                  25                  30          


Gln Arg Lys Gln Val Ser Asp Ser Gly Asp Ile Lys Ile Lys Ser Trp 
        35                  40                  45              


Arg Gly Asn Asn Lys Lys Glu Cys Trp Ser Tyr Leu Ser Xaa Asn Lys 
    50                  55                  60                  


Lys Met Lys Ser Asp Gly Leu Gly Ala Ser Gly His Ser Ser Ser Xaa 
65                  70                  75                  80  


Asn Arg Asn Ser Ile Asn Lys Xaa Leu Lys Gln Asp Asp Val Lys Glu 
                85                  90                  95      


Lys Asp Gly Xaa Lys Ile Ala Ser Lys Ile Xaa Lys Glu Leu Lys Xaa 
            100                 105                 110         


Gly Gly Lys Asn Val Ser Gly Lys Pro Lys Xaa Val Xaa Lys Ser Lys 
        115                 120                 125             


Xaa Glu Asn Gly Asp Lys Ala Arg Leu Glu Asn Met Ser Pro Arg Gln 
    130                 135                 140                 


Val Val Glu Arg Ser Ala Xaa Ala Ala Ala Ala Ala Xaa Gly Gln Lys 
145                 150                 155                 160 


Asn Leu Leu Asn Gly Lys Gly Val Arg Asn Gln Glu Gly Gln Ile Ser 
                165                 170                 175     


Gly Ala Arg Pro Lys Val Leu Xaa Gly Asn Leu Asn Val Gln Ala Lys 
            180                 185                 190         


Ala Lys Pro Leu Lys Lys Ala Xaa Gly Lys Asp Ser Pro Cys Leu Ser 
        195                 200                 205             


Ile Ala Gly Pro Ser Ser Arg Ser Xaa Asp Ser Ser Met Glu Phe Ser 
    210                 215                 220                 


Ile Ser Xaa Glu Cys Leu Asp Glu Pro Lys Glu Asn Gly Ser Xaa Glu 
225                 230                 235                 240 


Glu Glu Lys Pro Ser Gly His Lys Leu Ser Phe Cys Asp Ser Pro Gly 
                245                 250                 255     


Gln Met Met Lys Asn Ser Val Asp Ser Val Lys Asn Ser Xaa Val Ala 
            260                 265                 270         


Ile Lys Ser Arg Pro Val Ser Arg Val Xaa Asn Gly Xaa Ser Asn Lys 
        275                 280                 285             


Lys Ser Ile His Glu Gln Asp Xaa Asn Val Asn Asn Ser Val Leu Lys 
    290                 295                 300                 


Lys Val Ser Gly Lys Gly Cys Ser Glu Pro Val Pro Gln Ala Ile Leu 
305                 310                 315                 320 


Lys Lys Arg Gly Xaa Ser Asn Gly Cys Xaa Ala Ala Gln Gln Arg Xaa 
                325                 330                 335     


Lys Ser Xaa Pro Ser Asn Leu Xaa Lys Xaa Gln Gly Ser Gln Gly Glu 
            340                 345                 350         


Ser Pro Asn Ser Val Lys Ser Ser Val Ser Ser Arg Gln Ser Asp Glu 
        355                 360                 365             


Asn Val Ala Lys Leu Asp His Asn Xaa Xaa Xaa Glu Lys Gln Ala Pro 
    370                 375                 380                 


Lys Arg Lys Met Val Lys Gln Val His Xaa Ala Leu Pro Lys Val Asn 
385                 390                 395                 400 


Ala Lys Ile Val Ala Met Pro Lys Asn Leu Asn Gln Ser Lys Lys Gly 
                405                 410                 415     


Glu Xaa Leu Asn Asn Lys Asp Ser Lys Gln Lys Met Pro Pro Gly Gln 
            420                 425                 430         


Val Ile Ser Lys Xaa Gln Pro Ser Ser Gln Arg Pro Leu Lys His Glu 
        435                 440                 445             


Xaa Ser Xaa Val Gln Lys Ser Met Phe His Asp Val Arg Asp Asn Asn 
    450                 455                 460                 


Asn Lys Asp Ser Val Ser Glu Gln Lys Pro His Lys Pro Leu Ile Asn 
465                 470                 475                 480 


Leu Ala Ser Glu Ile Ser Asp Ala Glu Ala Leu Gln Ser Ser Cys Arg 
                485                 490                 495     


Pro Asp Pro Gln Lys Pro Leu Asn Asp Gln Glu Lys Glu Lys Leu Ala 
            500                 505                 510         


Leu Glu Cys Gln Asn Ile Ser Lys Leu Asp Lys Ser Leu Lys His Glu 
        515                 520                 525             


Leu Glu Ser Lys Gln Ile Cys Leu Asp Lys Ser Glu Xaa Lys Phe Pro 
    530                 535                 540                 


Asn His Lys Glu Xaa Asp Asp Cys Asp Ala Ala Asn Ile Cys Cys His 
545                 550                 555                 560 


Ser Val Gly Ser Asp Asn Val Asn Ser Lys Phe Tyr Ser Xaa Xaa Ala 
                565                 570                 575     


Leu Lys Tyr Met Val Ser Asn Pro Asn Glu Asn Ser Leu Asn Ser Asn 
            580                 585                 590         


Pro Val Cys Asp Leu Asp Ser Xaa Ser Ala Gly Gln Ile His Leu Ile 
        595                 600                 605             


Ser Asp Arg Glu Asn Gln Val Gly Arg Lys Asp Xaa Asn Lys Gln Ser 
    610                 615                 620                 


Ser Ile Lys Cys Val Glu Asp Val Ser Leu Cys Asn Pro Glu Arg Xaa 
625                 630                 635                 640 


Asn Gly Xaa Leu Asn Ser Ala Gln Glu Asp Lys Lys Ser Lys Val Pro 
                645                 650                 655     


Val Glu Gly Leu Xaa Ile Pro Ser Lys Leu Ser Asp Glu Ser Ala Met 
            660                 665                 670         


Asp Glu Asp Lys His Ala Xaa Ala Asp Ser Asp Val Ser Ser Lys Cys 
        675                 680                 685             


Phe Ser Gly Gln Leu Ser Glu Lys Asn Ser Pro Lys Asn Met Glu Xaa 
    690                 695                 700                 


Ser Glu Ser Pro Glu Ser His Glu Xaa Pro Glu Xaa Pro Phe Val Gly 
705                 710                 715                 720 


His Trp Asn Leu Ser Xaa Gly Val Leu His Gln Arg Glu Ser Pro Glu 
                725                 730                 735     


Ser Asp Xaa Gly Ser Ala Xaa Xaa Ser Ser Asp Asp Ile Lys Pro Arg 
            740                 745                 750         


Ser Glu Asp Tyr Asp Ala Gly Gly Ser Gln Asp Asp Asp Gly Ser Asn 
        755                 760                 765             


Asp Arg Gly Ile Ser Lys Cys Gly Xaa Met Leu Cys His Asp Phe Leu 
    770                 775                 780                 


Gly Arg Ser Ser Ser Asp Xaa Ser Xaa Pro Glu Glu Leu Lys Ile Tyr 
785                 790                 795                 800 


Asp Ser Asn Leu Arg Ile Glu Val Lys Met Lys Lys Gln Ser Asn Asn 
                805                 810                 815     


Asp Leu Phe Gln Val Asn Ser Xaa Ser Asp Asp Glu Ile Pro Arg Lys 
            820                 825                 830         


Arg Pro Glu Ile Trp Ser Arg Ser Ala Ile Val His Ser Arg Glu Arg 
        835                 840                 845             


Glu Asn Ile Pro Arg Gly Ser Val Gln Phe Ala Gln Glu Ile Asp Gln 
    850                 855                 860                 


Val Ser Ser Ser Ala Asp Glu Xaa Glu Asp Glu Arg Ser Glu Ala Glu 
865                 870                 875                 880 


Asn Val Ala Glu Asn Phe Ser Ile Ser Asn Pro Ala Pro Gln Gln Phe 
                885                 890                 895     


Gln Gly Ile Ile Asn Leu Ala Phe Glu Asp Ala Xaa Glu Asn Glu Cys 
            900                 905                 910         


Arg Glu Phe Ser Ala Xaa Lys Lys Phe Lys Arg Ser Val Leu Leu Ser 
        915                 920                 925             


Val Asp Glu Cys Glu Glu Leu Gly Ser Asp Glu Gly Glu Val His Xaa 
    930                 935                 940                 


Pro Phe Gln Ala Ser Val Asp Ser Phe Ser Pro Ser Asp Val Phe Asp 
945                 950                 955                 960 


Gly Ile Ser His Glu His His Gly Arg Xaa Cys Tyr Ser Arg Phe Ser 
                965                 970                 975     


Arg Glu Ser Glu Asp Asn Ile Leu Glu Cys Lys Gln Asn Lys Gly Asn 
            980                 985                 990         


Ser Val Cys Lys Asn Glu Ser Xaa  Val Leu Asp Leu Ser  Ser Ile Asp 
        995                 1000                 1005             


Ser Ser  Arg Lys Asn Lys Gln  Ser Val Ser Ala Xaa  Glu Lys Lys 
    1010                 1015                 1020             


Asn Xaa  Ile Asp Val Leu Ser  Ser Arg Ser Arg Gln  Leu Leu Arg 
    1025                 1030                 1035             


Glu Asp  Lys Lys Val Asn Asn  Gly Ser Asn Val Glu  Asn Asp Ile 
    1040                 1045                 1050             


Gln Gln  Arg Ser Lys Phe Leu  Asp Ser Asp Val Lys  Ser Gln Glu 
    1055                 1060                 1065             


Arg Pro  Cys His Leu Asp Leu  His Gln Arg Glu Pro  Asn Ser Asp 
    1070                 1075                 1080             


Ile Pro  Lys Asn Ser Ser Xaa  Lys Ser Leu Asp Ser  Phe Arg Ser 
    1085                 1090                 1095             


Gln Val  Leu Pro Gln Glu Gly  Pro Val Lys Glu Ser  His Ser Xaa 
    1100                 1105                 1110             


Xaa Xaa  Glu Lys Ala Asn Ile  Ala Leu Ser Ala Gly  Asp Ile Asp 
    1115                 1120                 1125             


Asp Cys  Asp Xaa Leu Ala Gln  Xaa Arg Met Tyr Asp  His Arg Pro 
    1130                 1135                 1140             


Ser Lys  Xaa Leu Ser Pro Ile  Tyr Glu Met Asp Val  Ile Glu Ala 
    1145                 1150                 1155             


Phe Glu  Gln Lys Val Glu Ser  Glu Xaa His Val Xaa  Asp Met Asp 
    1160                 1165                 1170             


Phe Glu  Asp Asp Gln His Phe  Ala Lys Gln Asp Trp  Xaa Leu Leu 
    1175                 1180                 1185             


Lys Gln  Leu Leu Ser Glu Gln  Asp Ser Asn Leu Asp  Val Xaa Asn 
    1190                 1195                 1200             


Ser Val  Pro Glu Asp Leu Ser  Leu Ala Gln Tyr Leu  Ile Asn Gln 
    1205                 1210                 1215             


Xaa Leu  Leu Leu Ala Arg Asp  Ser Ser Lys Pro Gln  Gly Ile Xaa 
    1220                 1225                 1230             


His Ile  Asp Xaa Leu Asn Arg  Trp Ser Glu Leu Xaa  Ser Pro Leu 
    1235                 1240                 1245             


Asp Ser  Ser Ala Ser Ile Xaa  Met Ala Ser Phe Ser  Ser Glu Asp 
    1250                 1255                 1260             


Cys Ser  Pro Gln Gly Glu Trp  Xaa Ile Leu Glu Leu  Glu Xaa Gln 
    1265                 1270                 1275             


His 
    


<210> 4496
<211> 178
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<400> 4496
Met Asp Arg Ala Ala Arg Cys Ser Gly Ala Ser Ser Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Leu Ala Leu Gly Leu Val Ile Leu His Cys Val Val Ala Asp 
            20                  25                  30          


Gly Asn Ser Xaa Arg Ser Pro Glu Xaa Asn Gly Leu Leu Cys Gly Asp 
        35                  40                  45              


Pro Glu Glu Asn Cys Ala Ala Xaa Xaa Xaa Gln Ser Lys Arg Lys Gly 
    50                  55                  60                  


His Phe Ser Arg Cys Pro Lys Gln Tyr Lys His Tyr Cys Ile Lys Gly 
65                  70                  75                  80  


Arg Cys Arg Phe Val Val Ala Glu Gln Xaa Pro Ser Cys Val Cys Asp 
                85                  90                  95      


Glu Gly Tyr Ile Gly Ala Arg Cys Glu Arg Val Asp Leu Phe Tyr Leu 
            100                 105                 110         


Arg Gly Asp Arg Gly Gln Ile Leu Val Ile Cys Leu Ile Ala Val Met 
        115                 120                 125             


Val Val Phe Ile Ile Leu Val Ile Gly Val Cys Xaa Cys Cys His Pro 
    130                 135                 140                 


Leu Arg Lys Arg Arg Lys Arg Lys Lys Lys Glu Glu Glu Met Glu Xaa 
145                 150                 155                 160 


Leu Gly Lys Asp Ile Xaa Pro Ile Asn Glu Asp Ile Glu Glu Xaa Asn 
                165                 170                 175     


Ile Ala 
        


<210> 4497
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<400> 4497
Xaa Leu Val Ile Leu His Cys Val Val Ala Asp Gly Asn Ser Xaa Arg 
1               5                   10                  15      


Ser Pro Glu Xaa Asn Gly Leu Leu Cys Gly Asp Pro Glu Glu Asn Cys 
            20                  25                  30          


Ala Ala Xaa Xaa Xaa Gln Ser Lys Arg Lys Gly His Phe Ser Arg Cys 
        35                  40                  45              


Pro Lys Gln Tyr Lys His Tyr Cys Ile Lys Gly Arg Cys Arg Phe Val 
    50                  55                  60                  


Val Ala Glu Gln Xaa Pro Ser Cys Val Pro Leu Arg Lys Arg Arg Lys 
65                  70                  75                  80  


Arg Lys Lys Lys Glu Glu Glu Met Glu Xaa Leu Gly Lys Asp Ile Xaa 
                85                  90                  95      


Pro Ile Asn Glu Asp Ile Glu Glu Xaa Asn Ile Ala 
            100                 105             


<210> 4498
<211> 158
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 4498
Met Ser His Gly Lys Gly Xaa Asp Met Leu Pro Glu Ile Ala Ala Ala 
1               5                   10                  15      


Val Gly Phe Leu Ser Ser Leu Leu Arg Xaa Arg Gly Cys Val Ser Glu 
            20                  25                  30          


Gln Arg Leu Lys Val Phe Ser Gly Ala Leu Gln Glu Ala Leu Xaa Glu 
        35                  40                  45              


His Tyr Lys His His Trp Phe Pro Glu Lys Pro Ser Lys Gly Ser Gly 
    50                  55                  60                  


Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro Ile Ile Ser Arg 
65                  70                  75                  80  


Val Ala Ser Gln Ile Gly Leu Ser Gln Pro Gln Leu His Gln Leu Leu 
                85                  90                  95      


Pro Ser Glu Leu Xaa Leu Trp Val Asp Pro Tyr Glu Val Ser Tyr Arg 
            100                 105                 110         


Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu Glu Ala Pro Leu 
        115                 120                 125             


Ala Ala Ser Cys Gly Leu Leu Xaa Cys Lys Asn Gln Val Leu Leu Gly 
    130                 135                 140                 


Arg Ser Ser Pro Ser Lys Asn Tyr Val Met Ala Val Ser Ser 
145                 150                 155             


<210> 4499
<211> 483
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<400> 4499
Met Ala Ala Val Ile Leu Glu Ser Ile Phe Leu Lys Arg Ser Gln Gln 
1               5                   10                  15      


Lys Lys Lys Xaa Ser Pro Leu Asn Phe Lys Lys Arg Leu Phe Leu Leu 
            20                  25                  30          


Xaa Val His Lys Leu Ser Tyr Tyr Glu Tyr Asp Phe Glu Arg Gly Arg 
        35                  40                  45              


Arg Gly Ser Lys Lys Gly Ser Ile Asp Val Glu Lys Ile Xaa Cys Val 
    50                  55                  60                  


Glu Xaa Val Val Pro Glu Lys Asn Pro Pro Pro Glu Arg Gln Ile Pro 
65                  70                  75                  80  


Arg Arg Gly Glu Glu Ser Ser Glu Met Glu Gln Ile Ser Ile Ile Glu 
                85                  90                  95      


Arg Phe Pro Tyr Pro Phe Gln Val Val Tyr Asp Glu Gly Pro Leu Tyr 
            100                 105                 110         


Val Phe Ser Pro Xaa Glu Glu Leu Arg Lys Arg Trp Ile His Gln Leu 
        115                 120                 125             


Lys Asn Val Ile Arg Tyr Asn Ser Asp Leu Val Gln Lys Tyr His Pro 
    130                 135                 140                 


Cys Phe Trp Ile Asp Gly Gln Tyr Leu Cys Cys Ser Gln Xaa Ala Lys 
145                 150                 155                 160 


Asn Ala Met Gly Cys Gln Ile Leu Glu Asn Arg Asn Gly Ser Leu Lys 
                165                 170                 175     


Pro Gly Ser Ser His Arg Lys Xaa Lys Lys Pro Leu Pro Pro Xaa Pro 
            180                 185                 190         


Glu Glu Asp Gln Ile Leu Lys Lys Pro Leu Pro Pro Glu Pro Ala Ala 
        195                 200                 205             


Ala Pro Val Ser Xaa Ser Glu Leu Lys Lys Val Val Ala Leu Tyr Asp 
    210                 215                 220                 


Tyr Met Pro Met Asn Ala Asn Asp Leu Gln Leu Arg Lys Gly Asp Glu 
225                 230                 235                 240 


Tyr Phe Ile Leu Glu Glu Ser Asn Leu Pro Trp Trp Arg Ala Arg Asp 
                245                 250                 255     


Lys Asn Gly Gln Glu Gly Tyr Ile Pro Ser Asn Tyr Val Xaa Glu Ala 
            260                 265                 270         


Glu Asp Ser Ile Glu Met Tyr Glu Trp Tyr Ser Lys His Met Xaa Arg 
        275                 280                 285             


Ser Gln Ala Glu Gln Leu Leu Lys Gln Glu Gly Lys Glu Gly Gly Phe 
    290                 295                 300                 


Ile Val Arg Asp Ser Ser Lys Ala Gly Lys Tyr Xaa Val Ser Val Phe 
305                 310                 315                 320 


Ala Lys Ser Xaa Gly Asp Pro Gln Gly Val Ile Arg His Tyr Val Val 
                325                 330                 335     


Cys Ser Xaa Pro Gln Ser Gln Tyr Tyr Leu Ala Ala Arg Asn Cys Leu 
            340                 345                 350         


Val Asn Asp Gln Gly Val Val Lys Val Ser Asp Phe Gly Leu Ser Arg 
        355                 360                 365             


Tyr Val Leu Asp Asp Glu Tyr Xaa Ser Ser Val Gly Ser Lys Phe Pro 
    370                 375                 380                 


Val Arg Trp Ser Pro Pro Glu Val Leu Met Tyr Ser Lys Phe Ser Ser 
385                 390                 395                 400 


Lys Ser Asp Ile Trp Ala Phe Gly Val Leu Met Trp Glu Ile Tyr Ser 
                405                 410                 415     


Leu Gly Lys Met Pro Tyr Glu Arg Phe Xaa Asn Ser Glu Xaa Ala Glu 
            420                 425                 430         


His Ile Ala Gln Gly Leu Arg Leu Tyr Arg Pro His Leu Ala Ser Glu 
        435                 440                 445             


Lys Val Tyr Xaa Ile Met Tyr Ser Cys Trp His Glu Lys Ala Asp Glu 
    450                 455                 460                 


Arg Pro Xaa Phe Lys Ile Leu Leu Ser Asn Ile Leu Asp Val Met Asp 
465                 470                 475                 480 


Glu Glu Ser 
            


<210> 4500
<211> 568
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<400> 4500
Met Ala Ala Val Ile Leu Glu Ser Ile Phe Leu Lys Arg Ser Gln Gln 
1               5                   10                  15      


Lys Lys Lys Xaa Ser Pro Leu Asn Phe Lys Lys Arg Leu Phe Leu Leu 
            20                  25                  30          


Xaa Val His Lys Leu Ser Tyr Tyr Glu Tyr Asp Phe Glu Arg Gly Arg 
        35                  40                  45              


Arg Gly Ser Lys Lys Gly Ser Ile Asp Val Glu Lys Ile Xaa Cys Val 
    50                  55                  60                  


Glu Xaa Val Val Pro Glu Lys Asn Pro Pro Pro Glu Arg Gln Ile Pro 
65                  70                  75                  80  


Arg Arg Gly Glu Glu Ser Ser Glu Met Glu Gln Ile Ser Ile Ile Glu 
                85                  90                  95      


Arg Phe Pro Tyr Pro Phe Gln Val Val Tyr Asp Glu Gly Pro Leu Tyr 
            100                 105                 110         


Val Phe Ser Pro Xaa Glu Glu Leu Arg Lys Arg Trp Ile His Gln Leu 
        115                 120                 125             


Lys Asn Val Ile Arg Tyr Asn Ser Asp Leu Val Gln Lys Tyr His Pro 
    130                 135                 140                 


Cys Phe Trp Ile Asp Gly Gln Tyr Leu Cys Cys Ser Gln Xaa Ala Lys 
145                 150                 155                 160 


Asn Ala Met Gly Cys Gln Ile Leu Glu Asn Arg Asn Gly Ser Leu Lys 
                165                 170                 175     


Pro Gly Ser Ser His Arg Lys Xaa Lys Lys Pro Leu Pro Pro Xaa Pro 
            180                 185                 190         


Glu Glu Asp Gln Ile Leu Lys Lys Pro Leu Pro Pro Glu Pro Ala Ala 
        195                 200                 205             


Ala Pro Val Ser Xaa Ser Glu Leu Lys Lys Val Val Ala Leu Tyr Asp 
    210                 215                 220                 


Tyr Met Pro Met Asn Ala Asn Asp Leu Gln Leu Arg Lys Gly Asp Glu 
225                 230                 235                 240 


Tyr Phe Ile Leu Glu Glu Ser Asn Leu Pro Trp Trp Arg Ala Arg Asp 
                245                 250                 255     


Lys Asn Gly Gln Glu Gly Tyr Ile Pro Ser Asn Tyr Val Xaa Glu Ala 
            260                 265                 270         


Glu Asp Ser Ile Glu Met Tyr Glu Trp Tyr Ser Lys His Met Xaa Arg 
        275                 280                 285             


Ser Gln Ala Glu Gln Leu Leu Lys Gln Glu Gly Lys Glu Gly Gly Phe 
    290                 295                 300                 


Ile Val Arg Asp Ser Ser Lys Ala Gly Lys Tyr Xaa Val Ser Val Phe 
305                 310                 315                 320 


Ala Lys Ser Xaa Gly Asp Pro Gln Gly Val Ile Arg His Tyr Val Val 
                325                 330                 335     


Cys Ser Xaa Pro Gln Ser Gln Tyr Tyr Leu Ala Glu Lys His Leu Phe 
            340                 345                 350         


Ser Xaa Ile Pro Glu Leu Ile Asn Tyr His Gln His Asn Ser Ala Gly 
        355                 360                 365             


Leu Ile Ser Arg Leu Lys Tyr Pro Val Ser Gln Gln Asn Lys Asn Ala 
    370                 375                 380                 


Pro Ser Xaa Ala Gly Leu Gly Tyr Gly Ser Trp Glu Ile Asp Pro Lys 
385                 390                 395                 400 


Asp Leu Xaa Phe Leu Lys Glu Leu Gly Xaa Gly Gln Phe Gly Val Val 
                405                 410                 415     


Lys Tyr Gly Lys Trp Arg Gly Gln Tyr Asp Val Ala Ile Lys Met Ile 
            420                 425                 430         


Lys Glu Gly Ser Met Ser Glu Asp Glu Phe Ile Glu Glu Ala Lys Val 
        435                 440                 445             


Met Met Asn Leu Ser His Glu Lys Leu Val Gln Leu Tyr Gly Val Cys 
    450                 455                 460                 


Xaa Lys Gln Arg Pro Ile Phe Ile Ile Xaa Glu Tyr Met Ala Asn Gly 
465                 470                 475                 480 


Cys Leu Leu Asn Tyr Leu Arg Glu Met Arg His Arg Phe Gln Xaa Gln 
                485                 490                 495     


Gln Leu Leu Glu Met Cys Lys Asp Val Cys Glu Ala Met Glu Tyr Leu 
            500                 505                 510         


Glu Ser Lys Gln Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
        515                 520                 525             


Val Asn Asp Gln Gly Val Val Lys Val Ser Asp Phe Gly Leu Ser Arg 
    530                 535                 540                 


Tyr Val Leu Asp Asp Glu Tyr Xaa Ser Ser Val Gly Ser Lys Phe Pro 
545                 550                 555                 560 


Val Arg Trp Ser Pro Pro Glu Ser 
                565             


<210> 4501
<211> 659
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<400> 4501
Met Ala Ala Val Ile Leu Glu Ser Ile Phe Leu Lys Arg Ser Gln Gln 
1               5                   10                  15      


Lys Lys Lys Xaa Ser Pro Leu Asn Phe Lys Lys Arg Leu Phe Leu Leu 
            20                  25                  30          


Xaa Val His Lys Leu Ser Tyr Tyr Glu Tyr Asp Phe Glu Arg Gly Arg 
        35                  40                  45              


Arg Gly Ser Lys Lys Gly Ser Ile Asp Val Glu Lys Ile Xaa Cys Val 
    50                  55                  60                  


Glu Xaa Val Val Pro Glu Lys Asn Pro Pro Pro Glu Arg Gln Ile Pro 
65                  70                  75                  80  


Arg Arg Gly Glu Glu Ser Ser Glu Met Glu Gln Ile Ser Ile Ile Glu 
                85                  90                  95      


Arg Phe Pro Tyr Pro Phe Gln Val Val Tyr Asp Glu Gly Pro Leu Tyr 
            100                 105                 110         


Val Phe Ser Pro Xaa Glu Glu Leu Arg Lys Arg Trp Ile His Gln Leu 
        115                 120                 125             


Lys Asn Val Ile Arg Tyr Asn Ser Asp Leu Val Gln Lys Tyr His Pro 
    130                 135                 140                 


Cys Phe Trp Ile Asp Gly Gln Tyr Leu Cys Cys Ser Gln Xaa Ala Lys 
145                 150                 155                 160 


Asn Ala Met Gly Cys Gln Ile Leu Glu Asn Arg Asn Gly Ser Leu Lys 
                165                 170                 175     


Pro Gly Ser Ser His Arg Lys Xaa Lys Lys Pro Leu Pro Pro Xaa Pro 
            180                 185                 190         


Glu Glu Asp Gln Ile Leu Lys Lys Pro Leu Pro Pro Glu Pro Ala Ala 
        195                 200                 205             


Ala Pro Val Ser Xaa Ser Glu Leu Lys Lys Val Val Ala Leu Tyr Asp 
    210                 215                 220                 


Tyr Met Pro Met Asn Ala Asn Asp Leu Gln Leu Arg Lys Gly Asp Glu 
225                 230                 235                 240 


Tyr Phe Ile Leu Glu Glu Ser Asn Leu Pro Trp Trp Arg Ala Arg Asp 
                245                 250                 255     


Lys Asn Gly Gln Glu Gly Tyr Ile Pro Ser Asn Tyr Val Xaa Glu Ala 
            260                 265                 270         


Glu Asp Ser Ile Glu Met Tyr Glu Trp Tyr Ser Lys His Met Xaa Arg 
        275                 280                 285             


Ser Gln Ala Glu Gln Leu Leu Lys Gln Glu Gly Lys Glu Gly Gly Phe 
    290                 295                 300                 


Ile Val Arg Asp Ser Ser Lys Ala Gly Lys Tyr Xaa Val Ser Val Phe 
305                 310                 315                 320 


Ala Lys Ser Xaa Gly Asp Pro Gln Gly Val Ile Arg His Tyr Val Val 
                325                 330                 335     


Cys Ser Xaa Pro Gln Ser Gln Tyr Tyr Leu Ala Glu Lys His Leu Phe 
            340                 345                 350         


Ser Xaa Ile Pro Glu Leu Ile Asn Tyr His Gln His Asn Ser Ala Gly 
        355                 360                 365             


Leu Ile Ser Arg Leu Lys Tyr Pro Val Ser Gln Gln Asn Lys Asn Ala 
    370                 375                 380                 


Pro Ser Xaa Ala Gly Leu Gly Tyr Gly Ser Trp Glu Ile Asp Pro Lys 
385                 390                 395                 400 


Asp Leu Xaa Phe Leu Lys Glu Leu Gly Xaa Gly Gln Phe Gly Val Val 
                405                 410                 415     


Lys Tyr Gly Lys Trp Arg Gly Gln Tyr Asp Val Ala Ile Lys Met Ile 
            420                 425                 430         


Lys Glu Gly Ser Met Ser Glu Asp Glu Phe Ile Glu Glu Ala Lys Val 
        435                 440                 445             


Met Met Asn Leu Ser His Glu Lys Leu Val Gln Leu Tyr Gly Val Cys 
    450                 455                 460                 


Xaa Lys Gln Arg Pro Ile Phe Ile Ile Xaa Glu Tyr Met Ala Asn Gly 
465                 470                 475                 480 


Cys Leu Leu Asn Tyr Leu Arg Glu Met Arg His Arg Phe Gln Xaa Gln 
                485                 490                 495     


Gln Leu Leu Glu Met Cys Lys Asp Val Cys Glu Ala Met Glu Tyr Leu 
            500                 505                 510         


Glu Ser Lys Gln Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
        515                 520                 525             


Val Asn Asp Gln Gly Val Val Lys Val Ser Asp Phe Gly Leu Ser Arg 
    530                 535                 540                 


Tyr Val Leu Asp Asp Glu Tyr Xaa Ser Ser Val Gly Ser Lys Phe Pro 
545                 550                 555                 560 


Val Arg Trp Ser Pro Pro Glu Val Leu Met Tyr Ser Lys Phe Ser Ser 
                565                 570                 575     


Lys Ser Asp Ile Trp Ala Phe Gly Val Leu Met Trp Glu Ile Tyr Ser 
            580                 585                 590         


Leu Gly Lys Met Pro Tyr Glu Arg Phe Xaa Asn Ser Glu Xaa Ala Glu 
        595                 600                 605             


His Ile Ala Gln Gly Leu Arg Leu Tyr Arg Pro His Leu Ala Ser Glu 
    610                 615                 620                 


Lys Val Tyr Xaa Ile Met Tyr Ser Cys Trp His Glu Lys Ala Asp Glu 
625                 630                 635                 640 


Arg Pro Xaa Phe Lys Ile Leu Leu Ser Asn Ile Leu Asp Val Met Asp 
                645                 650                 655     


Glu Glu Ser 
            


<210> 4502
<211> 693
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<400> 4502
Met Ala Ser Trp Ser Ile Gln Gln Met Val Ile Gly Cys Pro Leu Cys 
1               5                   10                  15      


Gly Arg His Cys Ser Gly Gly Glu His Xaa Gly Glu Leu Gln Lys Glu 
            20                  25                  30          


Glu Ala Met Ala Ala Val Ile Leu Glu Ser Ile Phe Leu Lys Arg Ser 
        35                  40                  45              


Gln Gln Lys Lys Lys Xaa Ser Pro Leu Asn Phe Lys Lys Arg Leu Phe 
    50                  55                  60                  


Leu Leu Xaa Val His Lys Leu Ser Tyr Tyr Glu Tyr Asp Phe Glu Arg 
65                  70                  75                  80  


Gly Arg Arg Gly Ser Lys Lys Gly Ser Ile Asp Val Glu Lys Ile Xaa 
                85                  90                  95      


Cys Val Glu Xaa Val Val Pro Glu Lys Asn Pro Pro Pro Glu Arg Gln 
            100                 105                 110         


Ile Pro Arg Arg Gly Glu Glu Ser Ser Glu Met Glu Gln Ile Ser Ile 
        115                 120                 125             


Ile Glu Arg Phe Pro Tyr Pro Phe Gln Val Val Tyr Asp Glu Gly Pro 
    130                 135                 140                 


Leu Tyr Val Phe Ser Pro Xaa Glu Glu Leu Arg Lys Arg Trp Ile His 
145                 150                 155                 160 


Gln Leu Lys Asn Val Ile Arg Tyr Asn Ser Asp Leu Val Gln Lys Tyr 
                165                 170                 175     


His Pro Cys Phe Trp Ile Asp Gly Gln Tyr Leu Cys Cys Ser Gln Xaa 
            180                 185                 190         


Ala Lys Asn Ala Met Gly Cys Gln Ile Leu Glu Asn Arg Asn Gly Ser 
        195                 200                 205             


Leu Lys Pro Gly Ser Ser His Arg Lys Xaa Lys Lys Pro Leu Pro Pro 
    210                 215                 220                 


Xaa Pro Glu Glu Asp Gln Ile Leu Lys Lys Pro Leu Pro Pro Glu Pro 
225                 230                 235                 240 


Ala Ala Ala Pro Val Ser Xaa Ser Glu Leu Lys Lys Val Val Ala Leu 
                245                 250                 255     


Tyr Asp Tyr Met Pro Met Asn Ala Asn Asp Leu Gln Leu Arg Lys Gly 
            260                 265                 270         


Asp Glu Tyr Phe Ile Leu Glu Glu Ser Asn Leu Pro Trp Trp Arg Ala 
        275                 280                 285             


Arg Asp Lys Asn Gly Gln Glu Gly Tyr Ile Pro Ser Asn Tyr Val Xaa 
    290                 295                 300                 


Glu Ala Glu Asp Ser Ile Glu Met Tyr Glu Trp Tyr Ser Lys His Met 
305                 310                 315                 320 


Xaa Arg Ser Gln Ala Glu Gln Leu Leu Lys Gln Glu Gly Lys Glu Gly 
                325                 330                 335     


Gly Phe Ile Val Arg Asp Ser Ser Lys Ala Gly Lys Tyr Xaa Val Ser 
            340                 345                 350         


Val Phe Ala Lys Ser Xaa Gly Asp Pro Gln Gly Val Ile Arg His Tyr 
        355                 360                 365             


Val Val Cys Ser Xaa Pro Gln Ser Gln Tyr Tyr Leu Ala Glu Lys His 
    370                 375                 380                 


Leu Phe Ser Xaa Ile Pro Glu Leu Ile Asn Tyr His Gln His Asn Ser 
385                 390                 395                 400 


Ala Gly Leu Ile Ser Arg Leu Lys Tyr Pro Val Ser Gln Gln Asn Lys 
                405                 410                 415     


Asn Ala Pro Ser Xaa Ala Gly Leu Gly Tyr Gly Ser Trp Glu Ile Asp 
            420                 425                 430         


Pro Lys Asp Leu Xaa Phe Leu Lys Glu Leu Gly Xaa Gly Gln Phe Gly 
        435                 440                 445             


Val Val Lys Tyr Gly Lys Trp Arg Gly Gln Tyr Asp Val Ala Ile Lys 
    450                 455                 460                 


Met Ile Lys Glu Gly Ser Met Ser Glu Asp Glu Phe Ile Glu Glu Ala 
465                 470                 475                 480 


Lys Val Met Met Asn Leu Ser His Glu Lys Leu Val Gln Leu Tyr Gly 
                485                 490                 495     


Val Cys Xaa Lys Gln Arg Pro Ile Phe Ile Ile Xaa Glu Tyr Met Ala 
            500                 505                 510         


Asn Gly Cys Leu Leu Asn Tyr Leu Arg Glu Met Arg His Arg Phe Gln 
        515                 520                 525             


Xaa Gln Gln Leu Leu Glu Met Cys Lys Asp Val Cys Glu Ala Met Glu 
    530                 535                 540                 


Tyr Leu Glu Ser Lys Gln Phe Leu His Arg Asp Leu Ala Ala Arg Asn 
545                 550                 555                 560 


Cys Leu Val Asn Asp Gln Gly Val Val Lys Val Ser Asp Phe Gly Leu 
                565                 570                 575     


Ser Arg Tyr Val Leu Asp Asp Glu Tyr Xaa Ser Ser Val Gly Ser Lys 
            580                 585                 590         


Phe Pro Val Arg Trp Ser Pro Pro Glu Val Leu Met Tyr Ser Lys Phe 
        595                 600                 605             


Ser Ser Lys Ser Asp Ile Trp Ala Phe Gly Val Leu Met Trp Glu Ile 
    610                 615                 620                 


Tyr Ser Leu Gly Lys Met Pro Tyr Glu Arg Phe Xaa Asn Ser Glu Xaa 
625                 630                 635                 640 


Ala Glu His Ile Ala Gln Gly Leu Arg Leu Tyr Arg Pro His Leu Ala 
                645                 650                 655     


Ser Glu Lys Val Tyr Xaa Ile Met Tyr Ser Cys Trp His Glu Lys Ala 
            660                 665                 670         


Asp Glu Arg Pro Xaa Phe Lys Ile Leu Leu Ser Asn Ile Leu Asp Val 
        675                 680                 685             


Met Asp Glu Glu Ser 
    690             


<210> 4503
<211> 43
<212> PRT
<213> Homo sapiens

<400> 4503
Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met 
        35                  40              


<210> 4504
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<400> 4504
Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Xaa Met Ser Ala Glu Xaa Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro 
                85                  90          


<210> 4505
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 4505
Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Xaa Met Ser Ala Glu Xaa Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Xaa Ser Ile Leu Arg Asp Gly Ile Xaa Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Xaa Ala Ser 
        115                 


<210> 4506
<211> 352
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<400> 4506
Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Xaa Met Ser Ala Glu Xaa Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Xaa Ser Ile Leu Arg Asp Gly Ile Xaa Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Xaa Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asp Leu His Val Asp Val Lys Gly Tyr Lys Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Xaa Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn Ile Pro Xaa Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Xaa Ile Arg Ser 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Xaa Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Xaa Leu 
                245                 250                 255     


Pro Val Leu Leu Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln 
            260                 265                 270         


Gln Gln Glu Glu Lys Lys Xaa Gln Phe Arg Lys Lys Lys Arg Glu Gln 
        275                 280                 285             


Glu Leu Arg Glu Met Ala Trp Ser Xaa Met Lys Gln Glu Gln Ser Xaa 
    290                 295                 300                 


Arg Val Lys Leu Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala 
305                 310                 315                 320 


Ser Arg Gly Glu Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu 
                325                 330                 335     


Phe Lys Pro Gly Glu Glu Met Leu Gln Met Arg Leu His Phe Val Lys 
            340                 345                 350         


<210> 4507
<211> 378
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<400> 4507
Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Xaa Met Ser Ala Glu Xaa Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Xaa Ser Ile Leu Arg Asp Gly Ile Xaa Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Xaa Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asp Leu His Val Asp Val Lys Gly Tyr Lys Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Xaa Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn Ile Pro Xaa Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Xaa Ile Arg Ser 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Xaa Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Xaa Leu 
                245                 250                 255     


Pro Val Leu Leu Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln 
            260                 265                 270         


Gln Gln Glu Glu Lys Lys Xaa Gln Phe Arg Lys Lys Lys Arg Glu Gln 
        275                 280                 285             


Glu Leu Arg Glu Met Ala Trp Ser Xaa Met Lys Gln Glu Gln Ser Xaa 
    290                 295                 300                 


Arg Val Lys Leu Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala 
305                 310                 315                 320 


Ser Arg Gly Glu Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu 
                325                 330                 335     


Phe Lys Pro Gly Pro Pro Ile Gly Gln Xaa Gln Gln Gln Xaa Arg Gly 
            340                 345                 350         


Gln Gly Ser Pro Val Ala Leu Ser Gln Glu Ser Ala Gln Arg Xaa Asp 
        355                 360                 365             


Ser Trp Gly Pro Glu Glu Gly Gly Glu Ser 
    370                 375             


<210> 4508
<211> 513
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<400> 4508
Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Xaa Met Ser Ala Glu Xaa Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Xaa Ser Ile Leu Arg Asp Gly Ile Xaa Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Xaa Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asp Leu His Val Asp Val Lys Gly Tyr Lys Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Xaa Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn Ile Pro Xaa Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Xaa Ile Arg Ser 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Xaa Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Xaa Leu 
                245                 250                 255     


Pro Val Leu Leu Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln 
            260                 265                 270         


Gln Gln Glu Glu Lys Lys Xaa Gln Phe Arg Lys Lys Lys Arg Glu Gln 
        275                 280                 285             


Glu Leu Arg Glu Met Ala Trp Ser Xaa Met Lys Gln Glu Gln Ser Xaa 
    290                 295                 300                 


Arg Val Lys Leu Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala 
305                 310                 315                 320 


Ser Arg Gly Glu Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu 
                325                 330                 335     


Phe Lys Pro Ala Asp Val Ile Leu Asp Pro Lys Xaa Ala Asn Pro Ile 
            340                 345                 350         


Leu Leu Val Ser Glu Asp Gln Arg Ser Val Gln Arg Ala Lys Glu Pro 
        355                 360                 365             


Gln Asp Leu Pro Asp Asn Pro Glu Arg Phe Asn Trp His Tyr Cys Val 
    370                 375                 380                 


Leu Gly Cys Glu Ser Phe Ile Ser Gly Arg His Tyr Trp Glu Val Glu 
385                 390                 395                 400 


Val Gly Asp Arg Lys Glu Trp His Ile Gly Val Cys Ser Lys Asn Val 
                405                 410                 415     


Gln Arg Lys Gly Trp Val Lys Met Xaa Pro Glu Asn Gly Phe Trp Xaa 
            420                 425                 430         


Met Gly Leu Xaa Asp Gly Asn Lys Tyr Arg Xaa Leu Xaa Glu Pro Arg 
        435                 440                 445             


Xaa Asn Leu Lys Leu Pro Lys Pro Pro Lys Lys Val Gly Val Phe Leu 
    450                 455                 460                 


Asp Tyr Glu Xaa Gly Asp Ile Ser Phe Tyr Asn Ala Val Asp Gly Ser 
465                 470                 475                 480 


His Ile His Xaa Phe Leu Asp Val Ser Phe Ser Glu Ala Leu Tyr Pro 
                485                 490                 495     


Val Phe Arg Ile Leu Xaa Leu Glu Pro Xaa Ala Leu Xaa Ile Cys Pro 
            500                 505                 510         


Ala 
    


<210> 4509
<211> 461
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<400> 4509
Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Xaa Met Ser Ala Glu Xaa Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Xaa Ser Ile Leu Arg Asp Gly Ile Xaa Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Xaa Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val Ile Met Arg Gly 
145                 150                 155                 160 


Ser Ser Gly Glu Gly Val Ser Cys Xaa Ile Arg Ser Ser Leu Leu Gly 
                165                 170                 175     


Leu Glu Lys Xaa Ala Ser Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser 
            180                 185                 190         


Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Xaa Leu Pro Val Leu Leu 
        195                 200                 205             


Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln Gln Gln Glu Glu 
    210                 215                 220                 


Lys Lys Xaa Gln Phe Arg Lys Lys Lys Arg Glu Gln Glu Leu Arg Glu 
225                 230                 235                 240 


Met Ala Trp Ser Xaa Met Lys Gln Glu Gln Ser Xaa Arg Val Lys Leu 
                245                 250                 255     


Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala Ser Arg Gly Glu 
            260                 265                 270         


Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu Phe Lys Pro Ala 
        275                 280                 285             


Asp Val Ile Leu Asp Pro Lys Xaa Ala Asn Pro Ile Leu Leu Val Ser 
    290                 295                 300                 


Glu Asp Gln Arg Ser Val Gln Arg Ala Lys Glu Pro Gln Asp Leu Pro 
305                 310                 315                 320 


Asp Asn Pro Glu Arg Phe Asn Trp His Tyr Cys Val Leu Gly Cys Glu 
                325                 330                 335     


Ser Phe Ile Ser Gly Arg His Tyr Trp Glu Val Glu Val Gly Asp Arg 
            340                 345                 350         


Lys Glu Trp His Ile Gly Val Cys Ser Lys Asn Val Gln Arg Lys Gly 
        355                 360                 365             


Trp Val Lys Met Xaa Pro Glu Asn Gly Phe Trp Xaa Met Gly Leu Xaa 
    370                 375                 380                 


Asp Gly Asn Lys Tyr Arg Xaa Leu Xaa Glu Pro Arg Xaa Asn Leu Lys 
385                 390                 395                 400 


Leu Pro Lys Pro Pro Lys Lys Val Gly Val Phe Leu Asp Tyr Glu Xaa 
                405                 410                 415     


Gly Asp Ile Ser Phe Tyr Asn Ala Val Asp Gly Ser His Ile His Xaa 
            420                 425                 430         


Phe Leu Asp Val Ser Phe Ser Glu Ala Leu Tyr Pro Val Phe Arg Ile 
        435                 440                 445             


Leu Xaa Leu Glu Pro Xaa Ala Leu Xaa Ile Cys Pro Ala 
    450                 455                 460     


<210> 4510
<211> 178
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<400> 4510
Met Glu Val Arg Trp Asp Arg Ser His Arg Tyr Pro Ala Val His Val 
1               5                   10                  15      


Tyr Met Asp Gly Asp His Val Ala Gly Glu Gln Met Ala Glu Tyr Arg 
            20                  25                  30          


Gly Arg Xaa Val Leu Val Ser Asp Ala Ile Asp Glu Gly Arg Leu Xaa 
        35                  40                  45              


Leu Gln Ile Leu Ser Ala Arg Pro Ser Asp Asp Gly Gln Tyr Arg Cys 
    50                  55                  60                  


Leu Phe Glu Lys Asp Asp Val Tyr Gln Glu Ala Ser Leu Asp Leu Lys 
65                  70                  75                  80  


Val Val Ser Leu Gly Ser Ser Pro Leu Ile Xaa Val Glu Gly Gln Glu 
                85                  90                  95      


Asp Gly Glu Met Gln Pro Met Cys Ser Ser Asp Gly Trp Phe Pro Gln 
            100                 105                 110         


Pro His Val Pro Trp Arg Asp Met Glu Gly Lys Xaa Ile Pro Ser Ser 
        115                 120                 125             


Ser Gln Ala Leu Xaa Gln Gly Ser His Gly Leu Phe His Val Gln Xaa 
    130                 135                 140                 


Leu Leu Arg Val Xaa Asn Ile Ser Ala Val Asp Val Xaa Cys Ser Ile 
145                 150                 155                 160 


Ser Ile Pro Phe Leu Gly Glu Glu Lys Ile Ala Xaa Phe Ser Leu Ser 
                165                 170                 175     


Gly Trp 
        


<210> 4511
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<400> 4511
Met Val Asp Phe Pro Gly Tyr Asn Leu Ser Gly Ala Val Ala Ser Phe 
1               5                   10                  15      


Leu Phe Ile Leu Leu Xaa Met Lys Gln Ser Asp Phe Arg Val Ile Gly 
            20                  25                  30          


Pro Ala His Pro Ile Leu Ala Gly Val Gly Glu Asp Ala Leu Leu Xaa 
        35                  40                  45              


Cys Gln Leu Leu Pro Lys Arg Xaa Xaa Met His Val Glu Val Arg Trp 
    50                  55                  60                  


Tyr Arg Ser Glu Pro Ser Xaa Pro Val Phe Val His Arg Asp Gly Val 
65                  70                  75                  80  


Glu Val Xaa Glu Met Gln Met Glu Glu Tyr Arg Gly Trp Val Glu Trp 
                85                  90                  95      


Ile Glu Asn Gly Ile Ala Lys Gly Asn Val Ala Leu 
            100                 105             


<210> 4512
<211> 68
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 4512
Met Val Asp Phe Pro Gly Tyr Asn Leu Ser Gly Ala Val Ala Ser Phe 
1               5                   10                  15      


Leu Phe Ile Leu Leu Xaa Met Lys Gln Ser Glu Asp Phe Arg Val Ile 
            20                  25                  30          


Gly Pro Ala His Pro Ile Leu Ala Gly Val Gly Glu Asp Ala Leu Leu 
        35                  40                  45              


Xaa Cys Gln Leu Leu Pro Lys Arg Xaa Xaa Met His Val Glu Val Arg 
    50                  55                  60                  


Glu Xaa Pro Asp 
65              


<210> 4513
<211> 455
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<400> 4513
Met Val Asp Phe Pro Gly Tyr Asn Leu Ser Gly Ala Val Ala Ser Phe 
1               5                   10                  15      


Leu Phe Ile Leu Leu Xaa Met Lys Gln Ser Glu Asp Phe Arg Val Ile 
            20                  25                  30          


Gly Pro Ala His Pro Ile Leu Ala Gly Val Gly Glu Asp Ala Leu Leu 
        35                  40                  45              


Xaa Cys Gln Leu Leu Pro Lys Arg Xaa Xaa Met His Val Glu Val Arg 
    50                  55                  60                  


Trp Tyr Arg Ser Glu Pro Ser Xaa Pro Val Phe Val His Arg Asp Gly 
65                  70                  75                  80  


Val Glu Val Xaa Glu Met Gln Met Glu Glu Tyr Arg Gly Trp Val Glu 
                85                  90                  95      


Trp Ile Glu Asn Gly Ile Ala Lys Gly Asn Val Ala Leu Lys Ile His 
            100                 105                 110         


Asn Ile Gln Pro Ser Asp Asn Gly Gln Tyr Trp Cys His Phe Gln Asp 
        115                 120                 125             


Gly Asn Tyr Cys Gly Glu Xaa Ser Leu Leu Leu Lys Val Ala Gly Leu 
    130                 135                 140                 


Gly Ser Ala Pro Ser Ile His Met Glu Gly Pro Gly Glu Ser Gly Val 
145                 150                 155                 160 


Gln Leu Val Cys Xaa Ala Arg Gly Trp Phe Pro Glu Pro Gln Val Tyr 
                165                 170                 175     


Trp Glu Asp Ile Arg Gly Glu Lys Leu Leu Ala Val Ser Glu His Arg 
            180                 185                 190         


Ile Gln Asp Lys Asp Gly Leu Phe Tyr Ala Glu Ala Xaa Leu Val Val 
        195                 200                 205             


Arg Asn Ala Ser Ala Glu Ser Val Ser Cys Leu Val His Asn Pro Val 
    210                 215                 220                 


Leu Xaa Glu Glu Lys Gly Ser Val Ile Ser Leu Pro Glu Lys Leu Gln 
225                 230                 235                 240 


Xaa Glu Leu Ala Ser Leu Lys Val Asn Gly Pro Ser Gln Pro Ile Leu 
                245                 250                 255     


Val Arg Val Gly Glu Asp Ile Gln Leu Xaa Cys Tyr Leu Ser Pro Lys 
            260                 265                 270         


Ala Asn Ala Gln Ser Met Glu Val Arg Trp Asp Arg Ser His Arg Tyr 
        275                 280                 285             


Pro Ala Val His Val Tyr Met Asp Gly Asp His Val Ala Gly Glu Gln 
    290                 295                 300                 


Met Ala Glu Tyr Arg Gly Arg Xaa Val Leu Val Ser Asp Ala Ile Asp 
305                 310                 315                 320 


Glu Gly Arg Leu Xaa Leu Gln Ile Leu Ser Ala Arg Pro Ser Asp Asp 
                325                 330                 335     


Gly Gln Tyr Arg Cys Leu Phe Glu Lys Asp Asp Val Tyr Gln Glu Ala 
            340                 345                 350         


Ser Leu Asp Leu Lys Val Val Ser Leu Gly Ser Ser Pro Leu Ile Xaa 
        355                 360                 365             


Val Glu Gly Gln Glu Asp Gly Glu Met Gln Pro Met Cys Ser Ser Asp 
    370                 375                 380                 


Gly Trp Phe Pro Gln Pro His Val Pro Trp Arg Asp Met Glu Gly Lys 
385                 390                 395                 400 


Xaa Ile Pro Ser Ser Ser Gln Ala Leu Xaa Gln Gly Ser His Gly Leu 
                405                 410                 415     


Phe His Val Gln Xaa Leu Leu Arg Val Xaa Asn Ile Ser Ala Val Asp 
            420                 425                 430         


Val Xaa Cys Ser Ile Ser Ile Pro Phe Leu Gly Glu Glu Lys Ile Ala 
        435                 440                 445             


Xaa Phe Ser Leu Ser Gly Trp 
    450                 455 


<210> 4514
<211> 482
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<400> 4514
Met Val Asp Phe Pro Gly Tyr Asn Leu Ser Gly Ala Val Ala Ser Phe 
1               5                   10                  15      


Leu Phe Ile Leu Leu Xaa Met Lys Gln Ser Glu Asp Phe Arg Val Ile 
            20                  25                  30          


Gly Pro Ala His Pro Ile Leu Ala Gly Val Gly Glu Asp Ala Leu Leu 
        35                  40                  45              


Xaa Cys Gln Leu Leu Pro Lys Arg Xaa Xaa Met His Val Glu Val Arg 
    50                  55                  60                  


Trp Tyr Arg Ser Glu Pro Ser Xaa Pro Val Phe Val His Arg Asp Gly 
65                  70                  75                  80  


Val Glu Val Xaa Glu Met Gln Met Glu Glu Tyr Arg Gly Trp Val Glu 
                85                  90                  95      


Trp Ile Glu Asn Gly Ile Ala Lys Gly Asn Val Ala Leu Lys Ile His 
            100                 105                 110         


Asn Ile Gln Pro Ser Asp Asn Gly Gln Tyr Trp Cys His Phe Gln Asp 
        115                 120                 125             


Gly Asn Tyr Cys Gly Glu Xaa Ser Leu Leu Leu Lys Val Ala Gly Leu 
    130                 135                 140                 


Gly Ser Ala Pro Ser Ile His Met Glu Gly Pro Gly Glu Ser Gly Val 
145                 150                 155                 160 


Gln Leu Val Cys Xaa Ala Arg Gly Trp Phe Pro Glu Pro Gln Val Tyr 
                165                 170                 175     


Trp Glu Asp Ile Arg Gly Glu Lys Leu Leu Ala Val Ser Glu His Arg 
            180                 185                 190         


Ile Gln Asp Lys Asp Gly Leu Phe Tyr Ala Glu Ala Xaa Leu Val Val 
        195                 200                 205             


Arg Asn Ala Ser Ala Glu Ser Val Ser Cys Leu Val His Asn Pro Val 
    210                 215                 220                 


Leu Xaa Glu Glu Lys Gly Ser Val Ile Ser Leu Pro Glu Lys Leu Gln 
225                 230                 235                 240 


Xaa Glu Leu Ala Ser Leu Lys Val Asn Gly Pro Ser Gln Pro Ile Leu 
                245                 250                 255     


Val Arg Val Gly Glu Asp Ile Gln Leu Xaa Cys Tyr Leu Ser Pro Lys 
            260                 265                 270         


Ala Asn Ala Gln Ser Met Glu Val Arg Trp Asp Arg Ser His Arg Tyr 
        275                 280                 285             


Pro Ala Val His Val Tyr Met Asp Gly Asp His Val Ala Gly Glu Gln 
    290                 295                 300                 


Met Ala Glu Tyr Arg Gly Arg Xaa Val Leu Val Ser Asp Ala Ile Asp 
305                 310                 315                 320 


Glu Gly Arg Leu Xaa Leu Gln Ile Leu Ser Ala Arg Pro Ser Asp Asp 
                325                 330                 335     


Gly Gln Tyr Arg Cys Leu Phe Glu Lys Asp Asp Val Tyr Gln Glu Ala 
            340                 345                 350         


Ser Leu Asp Leu Lys Val Val Ser Leu Gly Ser Ser Pro Leu Ile Xaa 
        355                 360                 365             


Val Glu Gly Gln Glu Asp Gly Glu Met Gln Pro Met Cys Ser Ser Asp 
    370                 375                 380                 


Gly Trp Phe Pro Gln Pro His Val Pro Trp Arg Asp Met Glu Gly Lys 
385                 390                 395                 400 


Xaa Ile Pro Ser Ser Ser Gln Ala Leu Xaa Gln Gly Ser His Gly Leu 
                405                 410                 415     


Phe His Val Gln Xaa Leu Leu Arg Val Xaa Asn Ile Ser Ala Val Asp 
            420                 425                 430         


Val Xaa Cys Ser Ile Ser Ile Pro Phe Leu Gly Glu Glu Lys Ile Ala 
        435                 440                 445             


Xaa Phe Ser Leu Ser Glu Ser Arg Met Xaa Phe Leu Trp Lys Xaa Leu 
    450                 455                 460                 


Leu Val Trp Gly Leu Leu Leu Ala Val Ala Val Gly Leu Pro Arg Lys 
465                 470                 475                 480 


Arg Ser 
        


<210> 4515
<211> 605
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<400> 4515
Met Asp Pro Ala Glu Ala Val Leu Gln Glu Lys Ala Leu Lys Phe Met 
1               5                   10                  15      


Cys Ser Met Pro Arg Ser Leu Trp Leu Gly Cys Ser Ser Leu Ala Asp 
            20                  25                  30          


Ser Met Pro Ser Leu Arg Cys Leu Tyr Asn Pro Gly Xaa Gly Ala Leu 
        35                  40                  45              


Xaa Ala Phe Gln Asn Ser Ser Glu Arg Glu Asp Cys Asn Asn Gly Glu 
    50                  55                  60                  


Pro Pro Arg Lys Ile Ile Pro Glu Lys Asn Ser Leu Arg Gln Xaa Tyr 
65                  70                  75                  80  


Asn Ser Cys Ala Arg Leu Cys Leu Asn Gln Glu Xaa Val Cys Leu Ala 
                85                  90                  95      


Ser Xaa Ala Met Lys Xaa Glu Asn Cys Val Ala Lys Xaa Lys Leu Ala 
            100                 105                 110         


Asn Gly Xaa Ser Ser Met Ile Val Pro Lys Gln Arg Lys Leu Ser Ala 
        115                 120                 125             


Ser Tyr Glu Lys Glu Lys Glu Leu Cys Val Lys Tyr Phe Glu Gln Trp 
    130                 135                 140                 


Ser Glu Ser Asp Gln Val Glu Phe Val Glu His Leu Ile Ser Gln Met 
145                 150                 155                 160 


Cys His Tyr Gln His Gly His Ile Asn Ser Tyr Leu Lys Pro Met Leu 
                165                 170                 175     


Gln Arg Asp Phe Ile Xaa Ala Leu Pro Ala Arg Gly Leu Asp His Ile 
            180                 185                 190         


Ala Glu Asn Ile Leu Ser Tyr Leu Asp Ala Lys Ser Leu Cys Ala Ala 
        195                 200                 205             


Glu Leu Val Cys Lys Glu Trp Tyr Arg Val Xaa Ser Asp Gly Met Leu 
    210                 215                 220                 


Trp Lys Lys Leu Ile Glu Arg Met Val Arg Xaa Asp Ser Leu Trp Arg 
225                 230                 235                 240 


Gly Leu Ala Glu Arg Arg Gly Trp Gly Gln Tyr Leu Phe Lys Asn Lys 
                245                 250                 255     


Pro Pro Asp Gly Asn Ala Pro Pro Asn Ser Phe Tyr Arg Ala Leu Tyr 
            260                 265                 270         


Pro Lys Ile Ile Gln Asp Ile Glu Xaa Ile Glu Ser Asn Trp Arg Cys 
        275                 280                 285             


Gly Arg His Ser Leu Gln Arg Ile His Cys Arg Ser Glu Xaa Ser Lys 
    290                 295                 300                 


Gly Val Tyr Cys Leu Gln Tyr Asp Asp Gln Lys Ile Val Ser Gly Leu 
305                 310                 315                 320 


Arg Asp Asn Xaa Ile Lys Ile Trp Asp Lys Asn Xaa Leu Glu Cys Lys 
                325                 330                 335     


Arg Ile Leu Xaa Gly His Xaa Gly Ser Val Leu Cys Leu Gln Tyr Asp 
            340                 345                 350         


Glu Arg Val Ile Ile Xaa Gly Ser Ser Asp Ser Xaa Val Arg Val Trp 
        355                 360                 365             


Asp Val Asn Xaa Gly Glu Met Leu Asn Xaa Leu Ile His His Cys Glu 
    370                 375                 380                 


Ala Val Leu His Leu Arg Phe Asn Asn Gly Met Met Val Xaa Cys Ser 
385                 390                 395                 400 


Lys Asp Arg Ser Ile Ala Val Trp Asp Met Ala Ser Pro Xaa Asp Ile 
                405                 410                 415     


Xaa Leu Arg Arg Val Leu Val Gly His Arg Ala Ala Val Asn Val Val 
            420                 425                 430         


Asp Phe Asp Asp Lys Tyr Ile Val Ser Ala Ser Gly Asp Arg Xaa Ile 
        435                 440                 445             


Lys Val Trp Asn Xaa Ser Xaa Cys Glu Phe Val Arg Xaa Leu Asn Gly 
    450                 455                 460                 


His Lys Arg Gly Ile Ala Cys Leu Gln Tyr Arg Asp Arg Leu Val Val 
465                 470                 475                 480 


Ser Gly Ser Ser Asp Asn Xaa Ile Arg Leu Trp Asp Ile Glu Cys Gly 
                485                 490                 495     


Ala Cys Leu Arg Val Leu Glu Gly His Glu Glu Leu Val Arg Cys Ile 
            500                 505                 510         


Arg Phe Asp Asn Lys Arg Ile Val Ser Gly Ala Tyr Asp Gly Lys Ile 
        515                 520                 525             


Lys Val Trp Asp Leu Val Ala Ala Leu Asp Pro Arg Ala Pro Ala Gly 
    530                 535                 540                 


Xaa Leu Cys Leu Arg Xaa Leu Val Glu His Ser Gly Arg Val Phe Arg 
545                 550                 555                 560 


Leu Gln Phe Asp Glu Phe Gln Ile Val Ser Ser Ser His Asp Asp Xaa 
                565                 570                 575     


Ile Leu Ile Trp Asp Phe Leu Asn Asp Pro Ala Ala Gln Ala Glu Pro 
            580                 585                 590         


Pro Arg Ser Pro Ser Arg Xaa Tyr Xaa Tyr Ile Ser Arg 
        595                 600                 605 


<210> 4516
<211> 579
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<400> 4516
Met Asp Pro Ala Glu Ala Val Leu Gln Glu Lys Ala Leu Lys Phe Met 
1               5                   10                  15      


Cys Ser Met Pro Arg Ser Leu Trp Leu Gly Cys Ser Ser Leu Ala Asp 
            20                  25                  30          


Ser Met Pro Ser Leu Arg Cys Leu Tyr Asn Pro Gly Xaa Gly Ala Leu 
        35                  40                  45              


Xaa Ala Phe Gln Xaa Tyr Asn Ser Cys Ala Arg Leu Cys Leu Asn Gln 
    50                  55                  60                  


Glu Xaa Val Cys Leu Ala Ser Xaa Ala Met Lys Xaa Glu Asn Cys Val 
65                  70                  75                  80  


Ala Lys Xaa Lys Leu Ala Asn Gly Xaa Ser Ser Met Ile Val Pro Lys 
                85                  90                  95      


Gln Arg Lys Leu Ser Ala Ser Tyr Glu Lys Glu Lys Glu Leu Cys Val 
            100                 105                 110         


Lys Tyr Phe Glu Gln Trp Ser Glu Ser Asp Gln Val Glu Phe Val Glu 
        115                 120                 125             


His Leu Ile Ser Gln Met Cys His Tyr Gln His Gly His Ile Asn Ser 
    130                 135                 140                 


Tyr Leu Lys Pro Met Leu Gln Arg Asp Phe Ile Xaa Ala Leu Pro Ala 
145                 150                 155                 160 


Arg Gly Leu Asp His Ile Ala Glu Asn Ile Leu Ser Tyr Leu Asp Ala 
                165                 170                 175     


Lys Ser Leu Cys Ala Ala Glu Leu Val Cys Lys Glu Trp Tyr Arg Val 
            180                 185                 190         


Xaa Ser Asp Gly Met Leu Trp Lys Lys Leu Ile Glu Arg Met Val Arg 
        195                 200                 205             


Xaa Asp Ser Leu Trp Arg Gly Leu Ala Glu Arg Arg Gly Trp Gly Gln 
    210                 215                 220                 


Tyr Leu Phe Lys Asn Lys Pro Pro Asp Gly Asn Ala Pro Pro Asn Ser 
225                 230                 235                 240 


Phe Tyr Arg Ala Leu Tyr Pro Lys Ile Ile Gln Asp Ile Glu Xaa Ile 
                245                 250                 255     


Glu Ser Asn Trp Arg Cys Gly Arg His Ser Leu Gln Arg Ile His Cys 
            260                 265                 270         


Arg Ser Glu Xaa Ser Lys Gly Val Tyr Cys Leu Gln Tyr Asp Asp Gln 
        275                 280                 285             


Lys Ile Val Ser Gly Leu Arg Asp Asn Xaa Ile Lys Ile Trp Asp Lys 
    290                 295                 300                 


Asn Xaa Leu Glu Cys Lys Arg Ile Leu Xaa Gly His Xaa Gly Ser Val 
305                 310                 315                 320 


Leu Cys Leu Gln Tyr Asp Glu Arg Val Ile Ile Xaa Gly Ser Ser Asp 
                325                 330                 335     


Ser Xaa Val Arg Val Trp Asp Val Asn Xaa Gly Glu Met Leu Asn Xaa 
            340                 345                 350         


Leu Ile His His Cys Glu Ala Val Leu His Leu Arg Phe Asn Asn Gly 
        355                 360                 365             


Met Met Val Xaa Cys Ser Lys Asp Arg Ser Ile Ala Val Trp Asp Met 
    370                 375                 380                 


Ala Ser Pro Xaa Asp Ile Xaa Leu Arg Arg Val Leu Val Gly His Arg 
385                 390                 395                 400 


Ala Ala Val Asn Val Val Asp Phe Asp Asp Lys Tyr Ile Val Ser Ala 
                405                 410                 415     


Ser Gly Asp Arg Xaa Ile Lys Val Trp Asn Xaa Ser Xaa Cys Glu Phe 
            420                 425                 430         


Val Arg Xaa Leu Asn Gly His Lys Arg Gly Ile Ala Cys Leu Gln Tyr 
        435                 440                 445             


Arg Asp Arg Leu Val Val Ser Gly Ser Ser Asp Asn Xaa Ile Arg Leu 
    450                 455                 460                 


Trp Asp Ile Glu Cys Gly Ala Cys Leu Arg Val Leu Glu Gly His Glu 
465                 470                 475                 480 


Glu Leu Val Arg Cys Ile Arg Phe Asp Asn Lys Arg Ile Val Ser Gly 
                485                 490                 495     


Ala Tyr Asp Gly Lys Ile Lys Val Trp Asp Leu Val Ala Ala Leu Asp 
            500                 505                 510         


Pro Arg Ala Pro Ala Gly Xaa Leu Cys Leu Arg Xaa Leu Val Glu His 
        515                 520                 525             


Ser Gly Arg Val Phe Arg Leu Gln Phe Asp Glu Phe Gln Ile Val Ser 
    530                 535                 540                 


Ser Ser His Asp Asp Xaa Ile Leu Ile Trp Asp Phe Leu Asn Asp Pro 
545                 550                 555                 560 


Ala Ala Gln Ala Glu Pro Pro Arg Ser Pro Ser Arg Xaa Tyr Xaa Tyr 
                565                 570                 575     


Ile Ser Arg 
            


<210> 4517
<211> 569
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<400> 4517
Met Asp Pro Ala Glu Ala Val Leu Gln Glu Lys Ala Leu Lys Phe Met 
1               5                   10                  15      


Asn Ser Ser Glu Arg Glu Asp Cys Asn Asn Gly Glu Pro Pro Arg Lys 
            20                  25                  30          


Ile Ile Pro Glu Lys Asn Ser Leu Arg Gln Xaa Tyr Asn Ser Cys Ala 
        35                  40                  45              


Arg Leu Cys Leu Asn Gln Glu Xaa Val Cys Leu Ala Ser Xaa Ala Met 
    50                  55                  60                  


Lys Xaa Glu Asn Cys Val Ala Lys Xaa Lys Leu Ala Asn Gly Xaa Ser 
65                  70                  75                  80  


Ser Met Ile Val Pro Lys Gln Arg Lys Leu Ser Ala Ser Tyr Glu Lys 
                85                  90                  95      


Glu Lys Glu Leu Cys Val Lys Tyr Phe Glu Gln Trp Ser Glu Ser Asp 
            100                 105                 110         


Gln Val Glu Phe Val Glu His Leu Ile Ser Gln Met Cys His Tyr Gln 
        115                 120                 125             


His Gly His Ile Asn Ser Tyr Leu Lys Pro Met Leu Gln Arg Asp Phe 
    130                 135                 140                 


Ile Xaa Ala Leu Pro Ala Arg Gly Leu Asp His Ile Ala Glu Asn Ile 
145                 150                 155                 160 


Leu Ser Tyr Leu Asp Ala Lys Ser Leu Cys Ala Ala Glu Leu Val Cys 
                165                 170                 175     


Lys Glu Trp Tyr Arg Val Xaa Ser Asp Gly Met Leu Trp Lys Lys Leu 
            180                 185                 190         


Ile Glu Arg Met Val Arg Xaa Asp Ser Leu Trp Arg Gly Leu Ala Glu 
        195                 200                 205             


Arg Arg Gly Trp Gly Gln Tyr Leu Phe Lys Asn Lys Pro Pro Asp Gly 
    210                 215                 220                 


Asn Ala Pro Pro Asn Ser Phe Tyr Arg Ala Leu Tyr Pro Lys Ile Ile 
225                 230                 235                 240 


Gln Asp Ile Glu Xaa Ile Glu Ser Asn Trp Arg Cys Gly Arg His Ser 
                245                 250                 255     


Leu Gln Arg Ile His Cys Arg Ser Glu Xaa Ser Lys Gly Val Tyr Cys 
            260                 265                 270         


Leu Gln Tyr Asp Asp Gln Lys Ile Val Ser Gly Leu Arg Asp Asn Xaa 
        275                 280                 285             


Ile Lys Ile Trp Asp Lys Asn Xaa Leu Glu Cys Lys Arg Ile Leu Xaa 
    290                 295                 300                 


Gly His Xaa Gly Ser Val Leu Cys Leu Gln Tyr Asp Glu Arg Val Ile 
305                 310                 315                 320 


Ile Xaa Gly Ser Ser Asp Ser Xaa Val Arg Val Trp Asp Val Asn Xaa 
                325                 330                 335     


Gly Glu Met Leu Asn Xaa Leu Ile His His Cys Glu Ala Val Leu His 
            340                 345                 350         


Leu Arg Phe Asn Asn Gly Met Met Val Xaa Cys Ser Lys Asp Arg Ser 
        355                 360                 365             


Ile Ala Val Trp Asp Met Ala Ser Pro Xaa Asp Ile Xaa Leu Arg Arg 
    370                 375                 380                 


Val Leu Val Gly His Arg Ala Ala Val Asn Val Val Asp Phe Asp Asp 
385                 390                 395                 400 


Lys Tyr Ile Val Ser Ala Ser Gly Asp Arg Xaa Ile Lys Val Trp Asn 
                405                 410                 415     


Xaa Ser Xaa Cys Glu Phe Val Arg Xaa Leu Asn Gly His Lys Arg Gly 
            420                 425                 430         


Ile Ala Cys Leu Gln Tyr Arg Asp Arg Leu Val Val Ser Gly Ser Ser 
        435                 440                 445             


Asp Asn Xaa Ile Arg Leu Trp Asp Ile Glu Cys Gly Ala Cys Leu Arg 
    450                 455                 460                 


Val Leu Glu Gly His Glu Glu Leu Val Arg Cys Ile Arg Phe Asp Asn 
465                 470                 475                 480 


Lys Arg Ile Val Ser Gly Ala Tyr Asp Gly Lys Ile Lys Val Trp Asp 
                485                 490                 495     


Leu Val Ala Ala Leu Asp Pro Arg Ala Pro Ala Gly Xaa Leu Cys Leu 
            500                 505                 510         


Arg Xaa Leu Val Glu His Ser Gly Arg Val Phe Arg Leu Gln Phe Asp 
        515                 520                 525             


Glu Phe Gln Ile Val Ser Ser Ser His Asp Asp Xaa Ile Leu Ile Trp 
    530                 535                 540                 


Asp Phe Leu Asn Asp Pro Ala Ala Gln Ala Glu Pro Pro Arg Ser Pro 
545                 550                 555                 560 


Ser Arg Xaa Tyr Xaa Tyr Ile Ser Arg 
                565                 


<210> 4518
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<400> 4518
Met Pro Arg Ser Leu Trp Leu Gly Cys Ser Ser Leu Ala Asp Ser Met 
1               5                   10                  15      


Pro Ser Leu Arg Cys Leu Tyr Asn Pro Gly Xaa Gly Ala Leu Xaa Ala 
            20                  25                  30          


Phe Gln Asn Ser Ser Glu Arg Glu Asp Cys Asn Asn Gly Glu Pro Pro 
        35                  40                  45              


Arg Lys Ile Ile Pro Glu Lys Asn Ser Leu Arg Gln Xaa Tyr Asn Ser 
    50                  55                  60                  


Cys Ala Arg Leu Cys Leu Asn Gln Glu Xaa Val Cys Leu Ala Ser Xaa 
65                  70                  75                  80  


Ala Met Lys Xaa Glu Asn Cys Val Ala Lys Xaa Lys Leu Ala Asn Gly 
                85                  90                  95      


Xaa Ser Ser Met Ile Val Pro Lys Gln Arg Lys Leu Ser Ala Ser Tyr 
            100                 105                 110         


Glu Lys Glu Lys Glu Leu Cys Val Lys Tyr Phe Glu Gln Trp Ser Glu 
        115                 120                 125             


Ser Asp Gln Val Glu Phe Val Glu His Leu Ile Ser Gln Met Cys His 
    130                 135                 140                 


Tyr Gln His Gly His Ile Asn Ser Tyr Leu Lys Pro Met Leu Gln Arg 
145                 150                 155                 160 


Asp Phe Ile Xaa Ala Leu Pro Ala Arg Gly Leu Asp His Ile Ala Glu 
                165                 170                 175     


Asn Ile Leu Ser Tyr Leu Asp Ala Lys Ser Leu Cys Ala Ala Glu 
            180                 185                 190     


<210> 4519
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<400> 4519
Met Ile Ala Glu Xaa Glu Pro His Glu Gly Lys Arg Lys Val Glu Ser 
1               5                   10                  15      


Leu Trp Pro Ile Phe Arg Ile His His Gln Lys Xaa Arg Tyr Ile Phe 
            20                  25                  30          


Asp Leu Phe Tyr Lys Arg Lys Ala Ile Ser Arg Glu Leu Tyr Glu Tyr 
        35                  40                  45              


Cys Ile Lys Glu Gly Tyr Ala Asp Lys Asn Leu Ile Ala Lys Trp Lys 
    50                  55                  60                  


Lys Gln Gly Tyr Glu Asn Leu Cys Cys Leu Arg Cys Ile Gln Xaa Arg 
65                  70                  75                  80  


Asp Xaa Asn Phe Gly Xaa Asn Cys Ile Cys Arg Val Pro Lys Ser Lys 
                85                  90                  95      


Leu Glu Val Gly Arg Ile Ile Glu Cys Xaa His Cys Gly Cys Arg Gly 
            100                 105                 110         


Cys Ser Gly 
        115 


<210> 4520
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<400> 4520
Met Pro Lys Val Lys Arg Ser Arg Lys Ala Pro Pro Asp Gly Trp Glu 
1               5                   10                  15      


Leu Ile Glu Pro Xaa Leu Asp Glu Leu Asp Gln Lys Met Arg Glu Ala 
            20                  25                  30          


Glu Xaa Glu Pro His Glu Gly Lys Arg Lys Val Glu Ser Leu Trp Pro 
        35                  40                  45              


Ile Phe Arg Ile His His Gln Lys Xaa Arg Tyr Ile Phe Asp Leu Phe 
    50                  55                  60                  


Tyr Lys Arg Lys Ala Ile Ser Arg Glu Leu Tyr Glu Tyr Cys Ile Lys 
65                  70                  75                  80  


Glu Gly Tyr Ala Asp Lys Asn Leu Ile Ala Lys Trp Lys Lys Gln Gly 
                85                  90                  95      


Tyr Glu Asn Leu Cys Cys Leu Arg Cys Ile Gln Xaa Arg Asp Xaa Asn 
            100                 105                 110         


Phe Gly Xaa Asn Cys Ile Cys Arg Val Pro Lys Ser Lys Leu Glu Val 
        115                 120                 125             


Gly Arg Ile Ile Glu Cys Xaa His Cys Gly Cys Arg Gly Cys Ser Gly 
    130                 135                 140                 


<210> 4521
<211> 103
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<400> 4521
Met Pro Lys Val Lys Arg Ser Arg Lys Ala Pro Pro Asp Gly Trp Glu 
1               5                   10                  15      


Leu Ile Glu Pro Xaa Leu Asp Glu Leu Asp Gln Lys Met Arg Glu Glu 
            20                  25                  30          


Leu Tyr Glu Tyr Cys Ile Lys Glu Gly Tyr Ala Asp Lys Asn Leu Ile 
        35                  40                  45              


Ala Lys Trp Lys Lys Gln Gly Tyr Glu Asn Leu Cys Cys Leu Arg Cys 
    50                  55                  60                  


Ile Gln Xaa Arg Asp Xaa Asn Phe Gly Xaa Asn Cys Ile Cys Arg Val 
65                  70                  75                  80  


Pro Lys Ser Lys Leu Glu Val Gly Arg Ile Ile Glu Cys Xaa His Cys 
                85                  90                  95      


Gly Cys Arg Gly Cys Ser Gly 
            100             


<210> 4522
<211> 37
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<400> 4522
Met Pro Lys Val Lys Arg Ser Arg Lys Ala Pro Pro Asp Gly Trp Glu 
1               5                   10                  15      


Leu Ile Glu Pro Xaa Leu Asp Glu Leu Asp Gln Lys Met Arg Glu Gly 
            20                  25                  30          


Cys Ser Ala Val Ala 
        35          


<210> 4523
<211> 47
<212> PRT
<213> Homo sapiens

<400> 4523
Met Glu Pro Gly Gly Asp His Arg Ser Arg Ser Ser Gly Gly Arg Gly 
1               5                   10                  15      


Gly Pro Gly Pro Ala Val Ala Ser Ala Arg Gly Arg Arg Leu Pro Pro 
            20                  25                  30          


Ala Gly Ser Ser Gly Ser Ala Glu Pro Glu Glu Asp Glu Gly Asp 
        35                  40                  45          


<210> 4524
<211> 678
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<400> 4524
Met Glu Pro Gly Gly Asp His Arg Ser Arg Ser Ser Gly Gly Arg Gly 
1               5                   10                  15      


Gly Pro Gly Pro Ala Val Ala Ser Ala Arg Gly Arg Arg Leu Pro Pro 
            20                  25                  30          


Ala Gly Ser Ser Gly Ser Ala Glu Pro Glu Glu Asp Glu Gly Gly Gln 
        35                  40                  45              


Asp Leu Gln Leu Glu Gly Gly Ala Leu Gly Ser Trp Gly Ser Ala Pro 
    50                  55                  60                  


Leu Pro Ser Ser Arg Ala Arg Gly Pro Ala Ser Ser Gly Arg Lys Tyr 
65                  70                  75                  80  


Ser Asp His Cys Glu Ala Arg Ala Ser Arg Pro Gly Lys Ser Arg Ile 
                85                  90                  95      


Pro Gly Arg Asp His Arg Arg Tyr Tyr His Asp His Trp Arg Leu Glu 
            100                 105                 110         


Tyr Leu Met Asp Phe Asn Pro Ala Arg His Gly Met Val Cys Met Val 
        115                 120                 125             


Cys Gly Ser Ser Leu Ala Xaa Leu Lys Leu Ser Xaa Ile Lys Arg His 
    130                 135                 140                 


Ile Arg Gln Lys His Pro Tyr Ser Leu His Trp Ser Pro Arg Glu Lys 
145                 150                 155                 160 


Glu Val Ile Ser Asn Ser Trp Asp Ala His Leu Gly Leu Gly Ala Cys 
                165                 170                 175     


Gly Glu Ala Glu Gly Leu Gly Val Gln Gly Ala Glu Glu Glu Glu Glu 
            180                 185                 190         


Glu Glu Glu Glu Glu Glu Glu Glu Gly Ala Gly Val Pro Ala Cys Pro 
        195                 200                 205             


Pro Lys Gly Pro Gly Lys Ala Pro Ala Gly Gly Gly Cys Arg Arg Gln 
    210                 215                 220                 


Arg Arg Gly Gly Pro Val Ala Pro Arg Ala Arg Arg Leu Arg Leu Ser 
225                 230                 235                 240 


Ala Ser Arg Arg Ala Gly Gly Ser Arg Gly Leu Gly Ala Arg Arg Leu 
                245                 250                 255     


Glu Arg Arg Leu Lys Glu Ser Leu Gln Asn Trp Phe Arg Ala Glu Cys 
            260                 265                 270         


Leu Met Asp Tyr Asp Pro Arg Gly Asn Arg Leu Val Cys Met Ala Cys 
        275                 280                 285             


Gly Arg Ala Leu Pro Ser Leu His Leu Asp Asp Ile Arg Ala His Val 
    290                 295                 300                 


Leu Glu Val His Pro Gly Ser Leu Gly Leu Ser Gly Pro Gln Arg Ser 
305                 310                 315                 320 


Ala Leu Leu Gln Ala Trp Gly Gly Gln Pro Glu Ala Leu Ser Glu Leu 
                325                 330                 335     


Xaa Gln Ser Pro Pro Gly Asp Asp Leu Ala Pro Gln Asp Leu Xaa Gly 
            340                 345                 350         


Lys Ser Arg Asp Ser Ala Ser Ala Ala Gly Ala Pro Ser Ser Gln Asp 
        355                 360                 365             


Leu Ser Pro Pro Asp Val Lys Glu Glu Ala Gly Trp Val Pro Glu Arg 
    370                 375                 380                 


Pro Gly Pro Ala Glu Glu Glu Glu Glu Leu Glu Glu Gly Glu Gly Glu 
385                 390                 395                 400 


Arg Ala Gly Val Pro Gly Arg Ser Pro Arg Gly Arg Ala His Arg Arg 
                405                 410                 415     


His Pro Gln Glu Arg Trp Arg Leu Glu Tyr Leu Met Glu Leu Asp Gly 
            420                 425                 430         


Gly Arg Arg Gly Leu Val Cys Gly Val Cys Gly Gly Ala Leu Ala Ser 
        435                 440                 445             


Leu Lys Met Ser Xaa Ile Glu Arg His Ile Arg Arg Arg His Pro Gly 
    450                 455                 460                 


Ser Xaa Arg Leu Gly Gly Pro Val Gln Ala Leu Ile Ala Arg Glu Trp 
465                 470                 475                 480 


Ser Glu Lys Ala Ala His Leu Leu Ala Leu Gly Pro Pro Arg Pro Glu 
                485                 490                 495     


Ser Pro Gln Gly Pro Ile Pro Pro Gly Xaa Ala Ala Ala Ser Asp Glu 
            500                 505                 510         


Gly Gly Gly Asp Glu Glu Glu Glu Pro Glu Glu Glu Glu Glu Glu Trp 
        515                 520                 525             


Gly Asp Val Pro Leu Ser Pro Gly Ala Pro Leu Glu Arg Pro Ala Glu 
    530                 535                 540                 


Glu Glu Glu Asp Glu Glu Asp Gly Gln Glu Pro Gly Gly Leu Ala Leu 
545                 550                 555                 560 


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Arg Ser Arg Glu 
                565                 570                 575     


Gln Arg Arg Asn Tyr Gln Pro Arg Trp Arg Gly Glu Tyr Leu Met Asp 
            580                 585                 590         


Tyr Asp Gly Ser Arg Arg Gly Leu Val Cys Met Val Cys Gly Gly Ala 
        595                 600                 605             


Leu Ala Xaa Leu Lys Val Ser Xaa Ile Lys Arg His Ile Leu Gln Val 
    610                 615                 620                 


His Pro Phe Ser Met Asp Phe Xaa Pro Glu Glu Arg Gln Xaa Ile Leu 
625                 630                 635                 640 


Glu Ala Tyr Glu Glu Ala Ala Leu Arg Cys Tyr Gly His Glu Gly Phe 
                645                 650                 655     


Gly Pro Pro Ala Pro Ala Pro Arg Asp Gly Gly Ala Asp Leu Lys Ser 
            660                 665                 670         


Gly Ala Val Cys Arg Ala 
        675             


<210> 4525
<211> 276
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<400> 4525
Xaa Asn Ser Trp Asp Ala His Leu Gly Leu Gly Ala Cys Gly Glu Ala 
1               5                   10                  15      


Glu Gly Leu Gly Val Gln Gly Ala Glu Glu Glu Glu Glu Glu Glu Glu 
            20                  25                  30          


Glu Glu Glu Glu Glu Gly Ala Gly Val Pro Ala Cys Pro Pro Lys Gly 
        35                  40                  45              


Pro Gly Lys Ala Pro Ala Gly Gly Gly Cys Arg Arg Gln Arg Arg Gly 
    50                  55                  60                  


Gly Pro Val Ala Pro Arg Ala Arg Arg Leu Arg Leu Ser Ala Ser Arg 
65                  70                  75                  80  


Arg Ala Gly Gly Ser Arg Gly Leu Gly Ala Arg Arg Leu Glu Arg Arg 
                85                  90                  95      


Leu Lys Glu Ser Leu Gln Asn Trp Phe Arg Ala Glu Cys Leu Met Asp 
            100                 105                 110         


Tyr Asp Pro Arg Gly Asn Arg Leu Ala Trp Gly Gly Gln Pro Glu Ala 
        115                 120                 125             


Leu Ser Glu Leu Xaa Gln Ser Pro Pro Gly Asp Asp Leu Ala Pro Gln 
    130                 135                 140                 


Asp Leu Xaa Gly Lys Ser Arg Asp Ser Ala Ser Ala Ala Gly Ala Pro 
145                 150                 155                 160 


Ser Ser Gln Asp Leu Ser Pro Pro Asp Val Lys Glu Glu Ala Gly Trp 
                165                 170                 175     


Val Pro Glu Arg Pro Gly Pro Ala Glu Glu Glu Glu Glu Leu Glu Glu 
            180                 185                 190         


Gly Glu Gly Glu Arg Ala Gly Val Pro Gly Arg Ser Pro Arg Gly Arg 
        195                 200                 205             


Ala His Arg Arg His Pro Gln Glu Arg Trp Arg Leu Glu Tyr Leu Met 
    210                 215                 220                 


Glu Leu Asp Gly Gly Arg Arg Gly Leu Val Cys Gly Val Cys Gly Gly 
225                 230                 235                 240 


Ala Leu Ala Ser Leu Lys Met Ser Xaa Ile Glu Arg His Ile Arg Arg 
                245                 250                 255     


Arg His Pro Gly Ser Xaa Arg Leu Gly Gly Pro Val Gln Ala Leu Ile 
            260                 265                 270         


Ala Arg Glu Trp 
        275     


<210> 4526
<211> 202
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 4526
Xaa Val Ile Ser Asn Ser Trp Asp Ala His Leu Gly Leu Gly Ala Cys 
1               5                   10                  15      


Gly Glu Ala Glu Gly Leu Gly Val Gln Gly Ala Glu Glu Glu Glu Glu 
            20                  25                  30          


Glu Glu Glu Glu Glu Glu Glu Glu Gly Ala Gly Val Pro Ala Cys Pro 
        35                  40                  45              


Pro Lys Gly Pro Gly Asp Val Pro Leu Ser Pro Gly Ala Pro Leu Glu 
    50                  55                  60                  


Arg Pro Ala Glu Glu Glu Glu Asp Glu Glu Asp Gly Gln Glu Pro Gly 
65                  70                  75                  80  


Gly Leu Ala Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
                85                  90                  95      


Arg Ser Arg Glu Gln Arg Arg Asn Tyr Gln Pro Arg Trp Arg Gly Glu 
            100                 105                 110         


Tyr Leu Met Asp Tyr Asp Gly Ser Arg Arg Gly Leu Val Cys Met Val 
        115                 120                 125             


Cys Gly Gly Ala Leu Ala Xaa Leu Lys Val Ser Xaa Ile Lys Arg His 
    130                 135                 140                 


Ile Leu Gln Val His Pro Phe Ser Met Asp Phe Xaa Pro Glu Glu Arg 
145                 150                 155                 160 


Gln Xaa Ile Leu Glu Ala Tyr Glu Glu Ala Ala Leu Arg Cys Tyr Gly 
                165                 170                 175     


His Glu Gly Phe Gly Pro Pro Ala Pro Ala Pro Arg Asp Gly Gly Ala 
            180                 185                 190         


Asp Leu Lys Ser Gly Ala Val Cys Arg Ala 
        195                 200         


<210> 4527
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 4527
Phe Phe Leu His Gln Gln Gly Xaa Phe Glu Lys Glu Ile Gly Lys Ile 
1               5                   10                  15      


Ile Pro Phe Xaa Ile Ala Phe Lys Arg Ala Glu Ala Val Glu Pro Asp 
            20                  25                  30          


Gly Cys Val Gln Ser Trp Arg Cys Cys Leu Pro Cys Asp Leu Gly Gln 
        35                  40                  45              


Ala Ser Arg Phe Ile His Xaa Xaa Val Cys Ser Ala Ile Arg Trp Arg 
    50                  55                  60                  


Ser Cys Lys Gly Glu Arg Asn Phe Ala Glu Arg His Ile Leu Pro Ala 
65                  70                  75                  80  


Glu Leu Glu Glu Gln Ser Asn His Ala Gly Met Gly Pro Ile Leu Pro 
                85                  90                  95      


Ala Met Pro Ser Val Asp Gly Asn His Phe Gln His Pro Ala Gly Asp 
            100                 105                 110         


Cys His Pro Tyr Gly Ile Leu Cys Leu Gln Ala His Ser Ala Ser Val 
        115                 120                 125             


Xaa Ala Arg Gln Val Leu Gln 
    130                 135 


<210> 4528
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 4528
Met Phe Gln Asn Leu Gln Gly Xaa Phe Glu Lys Glu Ile Gly Lys Ile 
1               5                   10                  15      


Ile Pro Phe Xaa Ile Ala Phe Lys Arg Ala Glu Ala Val Glu Pro Asp 
            20                  25                  30          


Gly Cys Val Gln Ser Trp Arg Cys Cys Leu Pro Cys Asp Leu Gly Gln 
        35                  40                  45              


Ala Ser Arg Phe Ile His Xaa Xaa Val Cys Ser Ala Ile Arg Trp Arg 
    50                  55                  60                  


Ser Cys Lys Gly Glu Arg Asn Phe Ala Glu Arg His Ile Leu Pro Ala 
65                  70                  75                  80  


Glu Leu Glu Glu Gln Ser Asn His Ala Gly Met Gly Pro Ile Leu Pro 
                85                  90                  95      


Ala Met Pro Ser Val Asp Gly Asn His Phe Gln His Pro Ala Gly Asp 
            100                 105                 110         


Cys His Pro Tyr Gly Ile Leu Cys Leu Gln Ala His Ser Ala Ser Val 
        115                 120                 125             


Xaa Ala Arg Gln Val Leu Gln 
    130                 135 


<210> 4529
<211> 107
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<400> 4529
Met Leu Glu Arg Glu Asn Glu Ser His Gly Ser Lys Ser Cys Ser Arg 
1               5                   10                  15      


Ala Arg Ile Gly Xaa Glu Val Ala Cys Arg Ala Cys Leu Pro Pro His 
            20                  25                  30          


Cys Ala Met Pro Pro Ile Asp Ala Phe Leu Cys Leu Pro Phe Ser Phe 
        35                  40                  45              


Ala Leu Val Ser Gly Lys Leu Tyr Gln Trp Lys Glu Pro Val Ile Ser 
    50                  55                  60                  


Ser Val His Ser Lys Val Lys Arg Xaa Ala Glu Val Lys Glu Glu Ile 
65                  70                  75                  80  


Val Glu Lys Glu Met Lys Lys Leu Val His Ser Val Phe Asn Met Ala 
                85                  90                  95      


Asp Tyr Xaa Phe Pro Leu Gln Val Asn Xaa Trp 
            100                 105         


<210> 4530
<211> 49
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<400> 4530
Met Leu Arg Pro Ala Leu Pro Trp Leu Tyr Leu Gly Leu Cys Ser Leu 
1               5                   10                  15      


Leu Val Gly Glu Ala Glu Ala Pro Ser Pro Val Asp Pro Leu Glu Arg 
            20                  25                  30          


Ser Arg Pro Tyr Ala Val Leu Arg Gly Gln Asn Leu Asp Gln Xaa Leu 
        35                  40                  45              


His 
    


<210> 4531
<211> 76
<212> PRT
<213> Homo sapiens

<400> 4531
Met Leu Arg Pro Ala Leu Pro Trp Leu Tyr Leu Gly Leu Cys Ser Leu 
1               5                   10                  15      


Leu Val Gly Glu Ala Glu Ala Pro Ser Pro Val Asp Pro Leu Glu Arg 
            20                  25                  30          


Ser Arg Pro Tyr Ala Val Leu Arg Gly Gln Asn Leu Glu Ser Leu Ser 
        35                  40                  45              


Pro Arg Leu Glu Cys Asn Gly Ala Ile Ser Ala Arg Cys Asn Leu Arg 
    50                  55                  60                  


Val Trp Gly Ser Ser Asp Ser Pro Ala Ser Ala Pro 
65                  70                  75      


<210> 4532
<211> 61
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<400> 4532
Met Leu Arg Pro Ala Leu Pro Trp Leu Tyr Leu Gly Leu Cys Ser Leu 
1               5                   10                  15      


Leu Val Gly Glu Ala Glu Ala Pro Ser Pro Val Asp Pro Leu Glu Arg 
            20                  25                  30          


Ser Arg Pro Tyr Ala Val Leu Arg Gly Gln Asn Leu Glu Xaa Xaa Gly 
        35                  40                  45              


Glu Arg Ile Cys Leu Gln Leu Phe Ala Gln His Leu Xaa 
    50                  55                  60      


<210> 4533
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<400> 4533
Met Leu Arg Pro Ala Leu Pro Trp Leu Tyr Leu Gly Leu Cys Ser Leu 
1               5                   10                  15      


Leu Val Gly Glu Ala Glu Ala Pro Ser Pro Val Asp Pro Leu Glu Arg 
            20                  25                  30          


Ser Arg Pro Tyr Ala Val Leu Arg Gly Gln Asn Leu Val Leu Met Gly 
        35                  40                  45              


Xaa Ile Phe Ser Ile Leu Leu Val Xaa Val Ile Leu Met Ala Phe Cys 
    50                  55                  60                  


Val Tyr Lys Pro Ile Arg Arg Arg 
65                  70          


<210> 4534
<211> 641
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<400> 4534
Met Asp Gly Leu Gln Ala Ser Ala Gly Pro Leu Arg Arg Gly Arg Pro 
1               5                   10                  15      


Lys Arg Arg Arg Lys Pro Gln Pro His Ser Gly Ser Val Leu Ala Leu 
            20                  25                  30          


Pro Leu Arg Ser Arg Lys Ile Arg Lys Gln Leu Arg Ser Val Val Ser 
        35                  40                  45              


Arg Met Ala Ala Leu Arg Xaa Gln Xaa Leu Pro Ser Glu Asn Ser Glu 
    50                  55                  60                  


Glu Ser Arg Val Glu Ser Xaa Ala Asp Asp Leu Gly Asp Ala Leu Pro 
65                  70                  75                  80  


Gly Gly Ala Ala Val Ala Ala Val Pro Asp Ala Ala Arg Arg Glu Pro 
                85                  90                  95      


Tyr Gly His Leu Gly Pro Ala Glu Leu Leu Glu Ala Ser Pro Ala Ala 
            100                 105                 110         


Arg Ser Leu Gln Xaa Pro Ser Ala Arg Leu Val Pro Ala Ser Ala Pro 
        115                 120                 125             


Pro Ala Arg Leu Val Glu Val Pro Ala Ala Pro Val Arg Val Val Glu 
    130                 135                 140                 


Xaa Ser Ala Leu Leu Cys Xaa Ala Gln His Leu Ala Ala Val Gln Ser 
145                 150                 155                 160 


Ser Gly Ala Pro Ala Xaa Ala Ser Gly Pro Gln Val Asp Asn Xaa Gly 
                165                 170                 175     


Gly Glu Pro Ala Trp Asp Ser Pro Leu Arg Arg Val Leu Ala Glu Leu 
            180                 185                 190         


Asn Arg Ile Pro Ser Ser Arg Arg Arg Ala Ala Arg Leu Phe Glu Trp 
        195                 200                 205             


Leu Ile Ala Pro Met Pro Pro Asp His Phe Tyr Arg Arg Leu Trp Glu 
    210                 215                 220                 


Arg Glu Ala Val Leu Val Arg Arg Gln Asp His Xaa Tyr Tyr Gln Gly 
225                 230                 235                 240 


Leu Phe Ser Xaa Ala Asp Leu Asp Ser Met Leu Arg Asn Glu Glu Val 
                245                 250                 255     


Gln Phe Gly Gln His Leu Asp Ala Ala Arg Tyr Ile Asn Gly Arg Arg 
            260                 265                 270         


Glu Xaa Leu Asn Pro Pro Gly Arg Ala Leu Pro Ala Ala Ala Trp Ser 
        275                 280                 285             


Leu Tyr Gln Ala Gly Cys Ser Leu Arg Leu Leu Cys Pro Gln Ala Phe 
    290                 295                 300                 


Ser Xaa Xaa Val Trp Gln Phe Leu Ala Val Leu Gln Glu Gln Phe Gly 
305                 310                 315                 320 


Ser Met Ala Gly Ser Asn Val Tyr Leu Xaa Pro Pro Asn Ser Gln Gly 
                325                 330                 335     


Phe Ala Pro His Tyr Asp Asp Ile Glu Ala Phe Val Leu Gln Leu Glu 
            340                 345                 350         


Gly Arg Lys Leu Trp Arg Val Tyr Arg Pro Arg Val Pro Xaa Glu Glu 
        355                 360                 365             


Leu Ala Leu Xaa Ser Ser Pro Asn Phe Ser Gln Asp Asp Leu Gly Glu 
    370                 375                 380                 


Pro Val Leu Gln Xaa Val Leu Glu Pro Gly Asp Leu Leu Tyr Phe Pro 
385                 390                 395                 400 


Arg Gly Phe Ile His Gln Ala Glu Cys Gln Asp Gly Val His Ser Leu 
                405                 410                 415     


His Leu Xaa Leu Ser Xaa Tyr Gln Arg Asn Xaa Trp Gly Asp Phe Leu 
            420                 425                 430         


Glu Ala Ile Leu Pro Leu Ala Val Gln Ala Ala Met Glu Glu Asn Val 
        435                 440                 445             


Glu Phe Arg Arg Gly Leu Pro Arg Asp Phe Met Asp Tyr Met Gly Ala 
    450                 455                 460                 


Gln His Ser Asp Ser Lys Asp Pro Arg Arg Xaa Ala Phe Met Glu Lys 
465                 470                 475                 480 


Val Arg Val Leu Val Ala Arg Leu Gly His Phe Ala Pro Val Asp Ala 
                485                 490                 495     


Val Ala Asp Gln Arg Ala Lys Asp Phe Ile His Asp Ser Leu Pro Pro 
            500                 505                 510         


Val Leu Xaa Asp Arg Glu Arg Ala Leu Ser Val Tyr Gly Leu Pro Ile 
        515                 520                 525             


Arg Trp Glu Ala Gly Glu Pro Val Asn Val Gly Ala Gln Leu Xaa Xaa 
    530                 535                 540                 


Glu Xaa Glu Val His Met Leu Gln Asp Gly Ile Ala Arg Leu Val Gly 
545                 550                 555                 560 


Glu Gly Gly His Leu Phe Leu Tyr Tyr Xaa Val Glu Asn Ser Arg Val 
                565                 570                 575     


Tyr His Leu Glu Glu Pro Lys Cys Leu Glu Ile Tyr Pro Gln Gln Ala 
            580                 585                 590         


Asp Ala Met Glu Leu Leu Leu Gly Ser Tyr Pro Glu Phe Val Arg Val 
        595                 600                 605             


Gly Asp Leu Pro Cys Asp Ser Val Glu Asp Gln Leu Ser Leu Ala Xaa 
    610                 615                 620                 


Xaa Leu Tyr Asp Lys Gly Leu Leu Leu Xaa Lys Met Pro Leu Ala Leu 
625                 630                 635                 640 


Asn 
    


<210> 4535
<211> 114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 4535
Met Ile Gln Arg Ile Asn Lys Cys Cys Glu Asp Ile Lys Glu Asn Lys 
1               5                   10                  15      


Val Xaa Ile Cys Arg Ile His Glu Xaa Ile Asn Ala Xaa Asp Glu Glu 
            20                  25                  30          


Ile Asp His Tyr Cys Lys His Ser Glu Glu Ile Lys Asp Asn Cys Arg 
        35                  40                  45              


Asn Trp Lys Pro Xaa Cys Asp Val Phe Arg Lys His Glu Asp Tyr Met 
    50                  55                  60                  


Gln Asp Gln Phe Xaa Val Tyr Gln Gly Xaa Val Glu Lys Asp Lys Glu 
65                  70                  75                  80  


Met Tyr His Asp Tyr Ile Cys Gln Tyr Lys Glu Val Leu Lys Gln Tyr 
                85                  90                  95      


Gln Leu Lys Tyr Ser Glu Xaa Pro Phe Ser Arg Glu Tyr Tyr Glu Lys 
            100                 105                 110         


Lys Arg 
        


<210> 4536
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<400> 4536
Met Asn Asp Ser Leu Phe Val Ser Leu Asp Arg Leu Leu Leu Glu Phe 
1               5                   10                  15      


Val Phe Gln Tyr Glu Gln Asp Ile Ser Xaa Lys Glu Glu Met Ile Gln 
            20                  25                  30          


Arg Ile Asn Lys Cys Cys Glu Asp Ile Lys Glu Asn Lys Val Xaa Ile 
        35                  40                  45              


Cys Arg Ile His Glu Xaa Ile Asn Ala Xaa Asp Glu Glu Ile Asp His 
    50                  55                  60                  


Tyr Cys Lys His Ser Glu Glu Ile Lys Asp Asn Cys Arg Asn Trp Lys 
65                  70                  75                  80  


Pro Xaa Cys Asp Val Phe Arg Lys 
                85              


<210> 4537
<211> 587
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<400> 4537
Met Asn Asp Ser Leu Phe Val Ser Leu Asp Arg Leu Leu Leu Glu Phe 
1               5                   10                  15      


Val Phe Gln Tyr Glu Gln Asp Ile Ser Xaa Lys Glu Glu Met Ile Gln 
            20                  25                  30          


Arg Ile Asn Lys Cys Cys Glu Asp Ile Lys Glu Asn Lys Val Xaa Ile 
        35                  40                  45              


Cys Arg Ile His Glu Xaa Ile Asn Ala Xaa Asp Glu Glu Ile Asp His 
    50                  55                  60                  


Tyr Cys Lys His Ser Glu Glu Ile Lys Asp Asn Cys Arg Asn Trp Lys 
65                  70                  75                  80  


Pro Xaa Cys Asp Val Phe Arg Lys His Glu Asp Tyr Met Gln Asp Gln 
                85                  90                  95      


Phe Xaa Val Tyr Gln Gly Xaa Val Glu Lys Asp Lys Glu Met Tyr His 
            100                 105                 110         


Asp Tyr Ile Cys Gln Tyr Lys Glu Val Leu Lys Gln Tyr Gln Leu Lys 
        115                 120                 125             


Tyr Ser Glu Xaa Pro Phe Ser Arg Glu Tyr Tyr Glu Lys Lys Arg Glu 
    130                 135                 140                 


His Glu Glu Ile Gln Ser Arg Val Leu Ala Cys Xaa Glu Gln Leu Lys 
145                 150                 155                 160 


Met Asn Glu Xaa Ile Phe Met Lys Phe Arg Val Pro Ala Pro Phe Pro 
                165                 170                 175     


Ser Leu Xaa Lys Trp Xaa Leu Asn Ile Val Asn Leu Arg Cys Glu Xaa 
            180                 185                 190         


Gln Asp Ile Leu Lys His Ala Ser Asn Leu Xaa Lys Ser Ser Ser Glu 
        195                 200                 205             


Leu Lys Lys Glu Val Asp Glu Met Glu Ile Glu Ile Asn Tyr Leu Asn 
    210                 215                 220                 


Gln Gln Ile Ser Arg His Asn Glu Xaa Lys Ala Leu Ser Glu Xaa Leu 
225                 230                 235                 240 


Glu Glu Lys Asn Lys Asn Xaa Glu Asn Arg Lys Glu Leu Lys Glu Arg 
                245                 250                 255     


Ile Phe Gly Lys Asp Glu His Val Leu Xaa Leu Asn Lys Xaa Gln Ser 
            260                 265                 270         


Ser Gln Leu Phe Leu Pro Tyr Glu Ser Gln Lys Leu Val Arg Pro Ile 
        275                 280                 285             


Lys Met His Ser Ser Glu Pro Arg Val Ala Asp Ile Lys Glu Glu Ser 
    290                 295                 300                 


Ser Ala Lys Gln Ser Lys Leu Ala Asn Ile Asp Phe Arg Gln Lys Glu 
305                 310                 315                 320 


Asn Asp Xaa Gln Ile Phe Asn Asp Ser Ala Val Asp Asn His Ser Lys 
                325                 330                 335     


Cys Ser His Ile Xaa Xaa Ile Xaa Ser Ser Gln Lys Phe Met Gln Val 
            340                 345                 350         


Arg Leu Leu Xaa Pro Gln Lys Gln Ser Asn Ser Asn Gln Trp Ser Glu 
        355                 360                 365             


Lys Gly Asp Lys Asp Ala Glu Tyr Gly Asp Lys Gly Xaa Val Arg Gln 
    370                 375                 380                 


Val Arg Glu Ser Lys Cys Xaa Ser Gln Ala Ile Tyr Xaa Glu His Phe 
385                 390                 395                 400 


Gly Lys Ser Val Glu Asn Asp Ser Asp Glu Val Glu Glu Arg Ala Glu 
                405                 410                 415     


Asn Phe Pro Arg Xaa Ser Glu Ile Pro Ile Phe Leu Gly Xaa Pro Lys 
            420                 425                 430         


Ala Val Lys Ala Pro Glu Ser Leu Glu Lys Ile Lys Phe Pro Lys Xaa 
        435                 440                 445             


Pro Pro Phe Glu Ile Asn Arg Asn Arg Asn Ala Val Pro Glu Val Gln 
    450                 455                 460                 


Xaa Glu Lys Glu Ser Pro Gly Leu Ser Phe Leu Met Ser Tyr Xaa Ser 
465                 470                 475                 480 


Arg Ser Pro Gly Leu Asn Leu Phe Asp Ser Ser Val Phe Asp Xaa Glu 
                485                 490                 495     


Ile Ser Ser Asp Gln Phe Asn Glu His Tyr Ser Ala Arg Asn Leu Asn 
            500                 505                 510         


Pro Leu Ser Ser Glu Gln Glu Ile Gly Asn Leu Leu Glu Lys Pro Glu 
        515                 520                 525             


Gly Glu Asp Gly Phe Xaa Phe Ser Phe Pro Ser Asp Xaa Ser Xaa His 
    530                 535                 540                 


Xaa Phe Gly Ala Gly Lys Asp Asp Phe Ser Phe Pro Phe Ser Phe Gly 
545                 550                 555                 560 


Gln Gly Gln Asn Ser Ile Pro Ser Ser Ser Leu Lys Gly Phe Ser Ser 
                565                 570                 575     


Ser Ser Gln Asn Xaa Xaa Gln Phe Xaa Phe Phe 
            580                 585         


<210> 4538
<211> 37
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<400> 4538
Met Asn Asp Ser Leu Phe Val Ser Leu Asp Arg Leu Leu Leu Glu Phe 
1               5                   10                  15      


Val Phe Gln Tyr Glu Gln Asp Ile Ser Xaa Lys Glu Glu Met Ile Gln 
            20                  25                  30          


Arg Ile Asn Asn Ile 
        35          


<210> 4539
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<400> 4539
Xaa Asn Leu Phe Asp Ser Ser Val Phe Asp Xaa Glu Ile Ser Ser Asp 
1               5                   10                  15      


Gln Phe Asn Glu His Tyr Ser Ala Arg Asn Leu Asn Pro Leu Ser Ser 
            20                  25                  30          


Glu Gln Glu Ile Glu Lys Xaa Lys Cys Phe Arg Asn Glu Gly Lys Lys 
        35                  40                  45              


Gly His His Glu Leu Glu Asn Leu Gly Arg Ile His Arg Arg Gly Lys 
    50                  55                  60                  


Ile Glu Leu Gly Leu Tyr Ser Leu 
65                  70          


<210> 4540
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<400> 4540
Met Glu Xaa Trp Arg Lys Gly Ser Phe Arg Asn Ala Ser Phe Phe Lys 
1               5                   10                  15      


Gln Leu Ser Leu Gly Arg Pro Arg Arg Leu Arg Arg Gln Ser Ser Val 
            20                  25                  30          


Leu Ser Gln Ala Ser Xaa Ala Gly Gly Asp His Glu Glu Tyr Ser Asn 
        35                  40                  45              


Arg Glu Val Ile Arg Glu Leu Gln Gly Arg Pro Asp Gly Arg Arg Leu 
    50                  55                  60                  


Pro Leu Trp Gly Asp Glu Gln Pro Arg Ala Xaa Leu Leu Ala Pro Pro 
65                  70                  75                  80  


Lys Pro Pro Arg Leu Tyr Arg Glu Ser Ser Ser Cys Pro Asn Ile Leu 
                85                  90                  95      


Glu Pro Pro Pro Ala Tyr Xaa Ala Ala Tyr Ser Ala Xaa Leu Pro Ser 
            100                 105                 110         


Ala Leu Ser Leu Ser Ser Ala Leu His Gln His Ser Glu Lys Gly Leu 
        115                 120                 125             


Val Asp Xaa Pro Cys Phe Gln Arg Xaa Pro Xaa Pro Asp Leu Ser Asp 
    130                 135                 140                 


Pro Phe Leu Ser Phe Lys Val Asp Leu Gly Ile Ser Leu Leu Glu Glu 
145                 150                 155                 160 


Val Leu Gln Met Leu Arg Glu Gln Phe Pro Ser Glu Pro Ser Phe 
                165                 170                 175 


<210> 4541
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<400> 4541
Met Val Cys Ile Pro Cys Ile Val Ile Pro Val Leu Leu Trp Ile Tyr 
1               5                   10                  15      


Lys Lys Phe Leu Glu Pro Tyr Ile Tyr Pro Leu Val Ser Pro Phe Val 
            20                  25                  30          


Ser Arg Ile Trp Pro Lys Lys Ala Ile Gln Glu Ser Asn Asp Xaa Asn 
        35                  40                  45              


Lys Gly Lys Val Asn Phe Lys Gly Ala Asp Met Asn Gly Leu Pro Xaa 
    50                  55                  60                  


Lys Gly Pro Xaa Glu Ile Cys Asp Lys Lys Lys Asp 
65                  70                  75      


<210> 4542
<211> 728
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(697)
<223> Selenocysteine

<400> 4542
Met Glu Gly Glu Gly Val Arg Asn Phe Lys Glu Leu Arg Ala Lys Phe 
1               5                   10                  15      


Gln Asn Leu Asp Ala Pro Pro Leu Pro Gly Pro Ile Lys Phe Pro Ala 
            20                  25                  30          


Gly Val Ser Pro Lys Gly Asp Ile Gly Gly Xaa Gln Ser Xaa Gln Ile 
        35                  40                  45              


Leu Ala Asn Gly Lys Pro Leu Ser Ser Asn His Lys Gln Arg Xaa Pro 
    50                  55                  60                  


Tyr Cys Ser Ser Ser Glu Ser Gln Pro Leu Gln Pro Gln Lys Ile Lys 
65                  70                  75                  80  


Leu Ala Gln Lys Ser Glu Ile Pro Lys Cys Ser Asn Ser Pro Gly Pro 
                85                  90                  95      


Leu Gly Lys Ser Xaa Val Cys Ser Ala Xaa Ser Ser Gln Lys Ala Ser 
            100                 105                 110         


Leu Leu Leu Glu Val Xaa Gln Ser Asn Val Glu Ile Ile Xaa Lys Glu 
        115                 120                 125             


Lys Val Met Val Ala Asn Ser Phe Arg Asn Lys Leu Trp Asn Trp Glu 
    130                 135                 140                 


Lys Val Ser Ser Gln Lys Ser Glu Met Ser Ser Ala Leu Leu Leu Ala 
145                 150                 155                 160 


Asn Tyr Gly Ser Lys Ala Ile His Leu Glu Gly Gln Lys Gly Met Gly 
                165                 170                 175     


Leu Xaa Pro Glu Glu Pro Arg Lys Lys Leu Glu Xaa Lys Gly Ala Gln 
            180                 185                 190         


Xaa Leu Pro Ser Gln Lys His Val Val Ala Pro Lys Ile Leu His Asn 
        195                 200                 205             


Val Ser Glu Asp Pro Ser Phe Val Ile Ser Gln His Ile Arg Lys Ser 
    210                 215                 220                 


Trp Glu Asn Pro Pro Pro Glu Arg Ser Pro Ala Ser Ser Pro Cys Gln 
225                 230                 235                 240 


Pro Ile Tyr Glu Cys Glu Leu Ala Ser Gln Ala Pro Glu Lys Gln Pro 
                245                 250                 255     


Asp Val Arg His His His Leu Pro Lys Xaa Lys Pro Leu Pro Ser Ile 
            260                 265                 270         


Asp Ser Leu Gly Pro Pro Pro Pro Lys Pro Ser Arg Pro Pro Ile Val 
        275                 280                 285             


Asn Leu Gln Ala Phe Gln Arg Gln Pro Ala Ala Val Pro Lys Xaa Gln 
    290                 295                 300                 


Gly Glu Val Xaa Val Glu Glu Gly Ser Leu Ser Pro Glu Arg Leu Phe 
305                 310                 315                 320 


Asn Ala Glu Phe Glu Glu Pro His Asn Tyr Glu Ala Xaa Ile Ser Tyr 
                325                 330                 335     


Leu Arg His Ser Gly Asn Ser Ile Asn Leu Cys Xaa Ala Lys Glu Ile 
            340                 345                 350         


Ala Asp Pro Xaa Tyr Glu Val Gly Ile Glu Glu Leu Gln Lys Pro Gly 
        355                 360                 365             


Lys Asn Phe Pro Tyr Pro Glu Pro Ser Ala Lys His Glu Asp Lys Lys 
    370                 375                 380                 


Met Lys Glu Lys Gln Pro Cys Glu Leu Lys Pro Lys Asn Xaa Glu Lys 
385                 390                 395                 400 


Glu Pro Tyr Ser Asn His Val Phe Lys Val Asp Ala Cys Glu Gly Xaa 
                405                 410                 415     


Pro Glu Lys Ile Gln Met Xaa Asn Val His Xaa Gly Arg Arg Asn Met 
            420                 425                 430         


Leu Ala Gly Lys Gln Glu Ala Met Ile Asp Ile Ile Gln Xaa Asn Pro 
        435                 440                 445             


Cys Pro Glu Gly Pro Lys Leu Ala Arg His Ser Gln Gly His Cys Gly 
    450                 455                 460                 


His Leu Glu Val Leu Glu Ser Xaa Lys Glu Xaa Pro Asp Leu Gly Val 
465                 470                 475                 480 


Ser Lys Xaa Ser Ser Ile Ser Glu Glu Ile Tyr Asp Asp Val Glu Tyr 
                485                 490                 495     


Ser Arg Lys Glu Val Pro Lys Leu Asn Tyr Ser Ser Ser Leu Ala Ser 
            500                 505                 510         


Ser Ser Glu Glu Asn Arg Glu Leu Tyr Glu Asp Val Tyr Lys Xaa Lys 
        515                 520                 525             


Asn Asn Tyr Pro Lys Ile Asp Leu Asp Gly Lys Glu Ala Leu Lys Arg 
    530                 535                 540                 


Leu Gln Gln Phe Phe Lys Lys Glu Lys Asp Arg Phe Lys Ile Lys Lys 
545                 550                 555                 560 


Xaa Lys Ser Lys Glu Asn Leu Ser Ala Phe Ser Ile Leu Leu Pro Asp 
                565                 570                 575     


Leu Glu Leu Lys Ser Gln Glu Val Ile Ile Tyr Asp Asp Val Asp Leu 
            580                 585                 590         


Ser Glu Lys Glu Ser Lys Asp Glu Asp Lys Leu Lys Met Trp Lys Pro 
        595                 600                 605             


Lys Phe Leu Xaa Pro Lys Glu Lys Lys Glu Lys Asn Gly Ala Glu Glu 
    610                 615                 620                 


Ser Glu Ser Phe Ser Pro Arg Asn Phe Phe Lys Xaa Lys Lys Gln Asn 
625                 630                 635                 640 


Leu Glu Lys Asn Arg Met Lys Arg Glu Glu Lys Leu Phe Arg Glu Arg 
                645                 650                 655     


Phe Lys Tyr Asp Lys Glu Ile Ile Val Ile Asn Xaa Ala Val Ala Cys 
            660                 665                 670         


Ser Asn Asn Ser Arg Asn Gly Ile Phe Asp Leu Pro Ile Ser Pro Gly 
        675                 680                 685             


Glu Glu Leu Glu Val Ile Asp Xaa Xaa Glu Gln Asn Leu Val Ile Cys 
    690                 695                 700                 


Arg Asn Ser Lys Gly Lys Tyr Gly Tyr Val Leu Ile Glu His Leu Asp 
705                 710                 715                 720 


Phe Lys His Gln Ser Trp Ser Pro 
                725             


<210> 4543
<211> 221
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<400> 4543
Met Glu Gly Pro Arg Gly Trp Leu Val Leu Cys Val Leu Ala Ile Ser 
1               5                   10                  15      


Leu Ala Ser Met Val Xaa Glu Asp Leu Cys Arg Ala Pro Asp Gly Lys 
            20                  25                  30          


Lys Gly Glu Ala Gly Arg Pro Gly Arg Arg Gly Arg Pro Gly Leu Lys 
        35                  40                  45              


Gly Glu Gln Gly Glu Pro Gly Ala Pro Gly Ile Arg Xaa Gly Ile Gln 
    50                  55                  60                  


Gly Leu Lys Gly Asp Gln Gly Glu Pro Gly Pro Ser Gly Asn Pro Gly 
65                  70                  75                  80  


Lys Val Gly Tyr Pro Gly Pro Ser Gly Pro Leu Gly Ala Arg Gly Ile 
                85                  90                  95      


Pro Gly Ile Lys Gly Xaa Lys Gly Ser Pro Gly Asn Ile Lys Asp Gln 
            100                 105                 110         


Pro Arg Pro Ala Phe Ser Ala Ile Arg Arg Asn Pro Pro Met Gly Gly 
        115                 120                 125             


Asn Val Val Ile Phe Asp Xaa Val Ile Xaa Asn Gln Glu Glu Pro Tyr 
    130                 135                 140                 


Gln Asn His Ser Gly Arg Phe Val Cys Xaa Val Pro Gly Tyr Tyr Tyr 
145                 150                 155                 160 


Phe Xaa Phe Gln Val Leu Ser Gln Trp Glu Ile Cys Leu Ser Ile Val 
                165                 170                 175     


Ser Ser Ser Arg Gly Gln Val Arg Arg Ser Leu Gly Phe Cys Asp Xaa 
            180                 185                 190         


Xaa Asn Lys Gly Leu Phe Gln Val Val Ser Gly Gly Met Val Leu Gln 
        195                 200                 205             


Leu Gln Gln Gly Asp Gln Val Trp Val Glu Lys Asp Pro 
    210                 215                 220     


<210> 4544
<211> 245
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<400> 4544
Met Glu Gly Pro Arg Gly Trp Leu Val Leu Cys Val Leu Ala Ile Ser 
1               5                   10                  15      


Leu Ala Ser Met Val Xaa Glu Asp Leu Cys Arg Ala Pro Asp Gly Lys 
            20                  25                  30          


Lys Gly Glu Ala Gly Arg Pro Gly Arg Arg Gly Arg Pro Gly Leu Lys 
        35                  40                  45              


Gly Glu Gln Gly Glu Pro Gly Ala Pro Gly Ile Arg Xaa Gly Ile Gln 
    50                  55                  60                  


Gly Leu Lys Gly Asp Gln Gly Glu Pro Gly Pro Ser Gly Asn Pro Gly 
65                  70                  75                  80  


Lys Val Gly Tyr Pro Gly Pro Ser Gly Pro Leu Gly Ala Arg Gly Ile 
                85                  90                  95      


Pro Gly Ile Lys Gly Xaa Lys Gly Ser Pro Gly Asn Ile Lys Asp Gln 
            100                 105                 110         


Pro Arg Pro Ala Phe Ser Ala Ile Arg Arg Asn Pro Pro Met Gly Gly 
        115                 120                 125             


Asn Val Val Ile Phe Asp Xaa Val Ile Xaa Asn Gln Glu Glu Pro Tyr 
    130                 135                 140                 


Gln Asn His Ser Gly Arg Phe Val Cys Xaa Val Pro Gly Tyr Tyr Tyr 
145                 150                 155                 160 


Phe Xaa Phe Gln Val Leu Ser Gln Trp Glu Ile Cys Leu Ser Ile Val 
                165                 170                 175     


Ser Ser Ser Arg Gly Gln Val Arg Arg Ser Leu Gly Phe Cys Asp Xaa 
            180                 185                 190         


Xaa Asn Lys Gly Leu Phe Gln Val Val Ser Gly Gly Met Val Leu Gln 
        195                 200                 205             


Leu Gln Gln Gly Asp Gln Val Trp Val Glu Lys Asp Pro Lys Lys Gly 
    210                 215                 220                 


His Ile Tyr Gln Gly Ser Glu Ala Asp Ser Val Phe Ser Gly Phe Leu 
225                 230                 235                 240 


Ile Phe Pro Ser Ala 
                245 


<210> 4545
<211> 282
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<400> 4545
Met Leu Pro Leu Leu Arg Cys Val Pro Arg Val Leu Gly Ser Ser Val 
1               5                   10                  15      


Ala Gly Leu Arg Ala Ala Ala Pro Ala Ser Pro Phe Arg Gln Leu Leu 
            20                  25                  30          


Gln Pro Ala Pro Arg Leu Cys Xaa Arg Pro Phe Gly Leu Leu Ser Val 
        35                  40                  45              


Arg Ala Gly Ser Glu Arg Arg Pro Gly Leu Leu Arg Pro Arg Gly Pro 
    50                  55                  60                  


Cys Ala Cys Gly Cys Gly Cys Gly Ser Leu His Xaa Asp Gly Asp Lys 
65                  70                  75                  80  


Ala Phe Val Asp Phe Leu Ser Asp Glu Ile Lys Glu Glu Arg Lys Ile 
                85                  90                  95      


Gln Lys His Lys Xaa Leu Pro Lys Met Ser Gly Gly Trp Glu Leu Glu 
            100                 105                 110         


Leu Asn Gly Xaa Glu Ala Lys Leu Val Arg Lys Val Ala Gly Glu Lys 
        115                 120                 125             


Ile Xaa Val Xaa Phe Asn Ile Asn Asn Ser Ile Pro Pro Xaa Phe Asp 
    130                 135                 140                 


Gly Glu Glu Glu Pro Ser Gln Gly Gln Lys Val Glu Glu Gln Glu Pro 
145                 150                 155                 160 


Glu Leu Xaa Ser Xaa Pro Asn Phe Val Val Glu Val Ile Lys Asn Asp 
                165                 170                 175     


Asp Gly Lys Lys Ala Leu Val Leu Asp Cys His Tyr Pro Glu Asp Glu 
            180                 185                 190         


Val Gly Gln Glu Asp Glu Ala Glu Ser Asp Ile Phe Ser Ile Arg Glu 
        195                 200                 205             


Val Ser Phe Gln Ser Xaa Gly Glu Ser Glu Trp Lys Asp Xaa Asn Tyr 
    210                 215                 220                 


Xaa Leu Asn Xaa Asp Ser Leu Asp Trp Ala Leu Tyr Asp His Leu Met 
225                 230                 235                 240 


Asp Phe Leu Ala Asp Arg Gly Val Asp Asn Xaa Phe Ala Asp Glu Leu 
                245                 250                 255     


Val Glu Leu Ser Xaa Ala Leu Glu His Gln Glu Tyr Ile Xaa Phe Leu 
            260                 265                 270         


Glu Asp Leu Lys Ser Phe Val Lys Ser Gln 
        275                 280         


<210> 4546
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4546
Met Ser Gly Gly Trp Glu Leu Glu Leu 
1               5                   


<210> 4547
<211> 177
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 4547
Met Ser Gly Gly Trp Glu Leu Glu Leu Asn Gly Xaa Glu Ala Lys Leu 
1               5                   10                  15      


Val Arg Lys Val Ala Gly Glu Lys Ile Xaa Val Xaa Phe Asn Ile Asn 
            20                  25                  30          


Asn Ser Ile Pro Pro Xaa Phe Asp Gly Glu Glu Glu Pro Ser Gln Gly 
        35                  40                  45              


Gln Lys Val Glu Glu Gln Glu Pro Glu Leu Xaa Ser Xaa Pro Asn Phe 
    50                  55                  60                  


Val Val Glu Val Ile Lys Asn Asp Asp Gly Lys Lys Ala Leu Val Leu 
65                  70                  75                  80  


Asp Cys His Tyr Pro Glu Asp Glu Val Gly Gln Glu Asp Glu Ala Glu 
                85                  90                  95      


Ser Asp Ile Phe Ser Ile Arg Glu Val Ser Phe Gln Ser Xaa Gly Glu 
            100                 105                 110         


Ser Glu Trp Lys Asp Xaa Asn Tyr Xaa Leu Asn Xaa Asp Ser Leu Asp 
        115                 120                 125             


Trp Ala Leu Tyr Asp His Leu Met Asp Phe Leu Ala Asp Arg Gly Val 
    130                 135                 140                 


Asp Asn Xaa Phe Ala Asp Glu Leu Val Glu Leu Ser Xaa Ala Leu Glu 
145                 150                 155                 160 


His Gln Glu Tyr Ile Xaa Phe Leu Glu Asp Leu Lys Ser Phe Val Lys 
                165                 170                 175     


Ser 
    


<210> 4548
<211> 178
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 4548
Met Ser Gly Gly Trp Glu Leu Glu Leu Asn Gly Xaa Glu Ala Lys Leu 
1               5                   10                  15      


Val Arg Lys Val Ala Gly Glu Lys Ile Xaa Val Xaa Phe Asn Ile Asn 
            20                  25                  30          


Asn Ser Ile Pro Pro Xaa Phe Asp Gly Glu Glu Glu Pro Ser Gln Gly 
        35                  40                  45              


Gln Lys Val Glu Glu Gln Glu Pro Glu Leu Xaa Ser Xaa Pro Asn Phe 
    50                  55                  60                  


Val Val Glu Val Ile Lys Asn Asp Asp Gly Lys Lys Ala Leu Val Leu 
65                  70                  75                  80  


Asp Cys His Tyr Pro Glu Asp Glu Val Gly Gln Glu Asp Glu Ala Glu 
                85                  90                  95      


Ser Asp Ile Phe Ser Ile Arg Glu Val Ser Phe Gln Ser Xaa Gly Glu 
            100                 105                 110         


Ser Glu Trp Lys Asp Xaa Asn Tyr Xaa Leu Asn Xaa Asp Ser Leu Asp 
        115                 120                 125             


Trp Ala Leu Tyr Asp His Leu Met Asp Phe Leu Ala Asp Arg Gly Val 
    130                 135                 140                 


Asp Asn Xaa Phe Ala Asp Glu Leu Val Glu Leu Ser Xaa Ala Leu Glu 
145                 150                 155                 160 


His Gln Glu Tyr Ile Xaa Phe Leu Glu Asp Leu Lys Ser Phe Val Lys 
                165                 170                 175     


Ser Gln 
        


<210> 4549
<211> 281
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<400> 4549
Met Gly Ser Arg Gly Gln Gly Leu Leu Leu Ala Tyr Cys Leu Leu Leu 
1               5                   10                  15      


Ala Phe Ala Ser Gly Leu Val Leu Ser Arg Val Pro His Val Gln Gly 
            20                  25                  30          


Glu Gln Gln Glu Trp Glu Gly Xaa Glu Glu Leu Pro Ser Pro Pro Asp 
        35                  40                  45              


His Ala Glu Arg Ala Glu Glu Gln His Glu Lys Tyr Arg Pro Ser Gln 
    50                  55                  60                  


Asp Gln Gly Leu Pro Ala Ser Arg Cys Leu Arg Cys Cys Asp Pro Gly 
65                  70                  75                  80  


Xaa Ser Met Tyr Pro Ala Xaa Ala Val Pro Gln Ile Asn Ile Xaa Ile 
                85                  90                  95      


Leu Lys Gly Glu Lys Gly Asp Arg Gly Asp Arg Gly Leu Gln Gly Lys 
            100                 105                 110         


Tyr Gly Lys Xaa Gly Ser Ala Gly Ala Arg Gly His Xaa Gly Pro Lys 
        115                 120                 125             


Gly Gln Lys Gly Ser Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His 
    130                 135                 140                 


Tyr Ala Ala Phe Ser Val Gly Arg Lys Lys Pro Met His Ser Asn His 
145                 150                 155                 160 


Tyr Tyr Gln Xaa Val Ile Phe Asp Xaa Glu Phe Val Asn Leu Tyr Asp 
                165                 170                 175     


His Phe Asn Met Phe Xaa Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu 
            180                 185                 190         


Tyr Phe Phe Ser Leu Asn Val His Xaa Trp Asn Gln Lys Glu Xaa Tyr 
        195                 200                 205             


Leu His Ile Met Lys Asn Glu Glu Glu Val Val Ile Leu Phe Ala Gln 
    210                 215                 220                 


Val Gly Asp Arg Ser Ile Met Gln Ser Gln Ser Leu Met Leu Glu Leu 
225                 230                 235                 240 


Arg Glu Gln Asp Gln Val Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu 
                245                 250                 255     


Asn Ala Ile Phe Ser Glu Glu Leu Asp Xaa Tyr Ile Xaa Phe Ser Gly 
            260                 265                 270         


Tyr Leu Val Lys His Ala Xaa Glu Pro 
        275                 280     


<210> 4550
<211> 199
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<400> 4550
Met Tyr Pro Ala Xaa Ala Val Pro Gln Ile Asn Ile Xaa Ile Leu Lys 
1               5                   10                  15      


Gly Glu Lys Gly Asp Arg Gly Asp Arg Gly Leu Gln Gly Lys Tyr Gly 
            20                  25                  30          


Lys Xaa Gly Ser Ala Gly Ala Arg Gly His Xaa Gly Pro Lys Gly Gln 
        35                  40                  45              


Lys Gly Ser Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His Tyr Ala 
    50                  55                  60                  


Ala Phe Ser Val Gly Arg Lys Lys Pro Met His Ser Asn His Tyr Tyr 
65                  70                  75                  80  


Gln Xaa Val Ile Phe Asp Xaa Glu Phe Val Asn Leu Tyr Asp His Phe 
                85                  90                  95      


Asn Met Phe Xaa Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu Tyr Phe 
            100                 105                 110         


Phe Ser Leu Asn Val His Xaa Trp Asn Gln Lys Glu Xaa Tyr Leu His 
        115                 120                 125             


Ile Met Lys Asn Glu Glu Glu Val Val Ile Leu Phe Ala Gln Val Gly 
    130                 135                 140                 


Asp Arg Ser Ile Met Gln Ser Gln Ser Leu Met Leu Glu Leu Arg Glu 
145                 150                 155                 160 


Gln Asp Gln Val Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu Asn Ala 
                165                 170                 175     


Ile Phe Ser Glu Glu Leu Asp Xaa Tyr Ile Xaa Phe Ser Gly Tyr Leu 
            180                 185                 190         


Val Lys His Ala Xaa Glu Pro 
        195                 


<210> 4551
<211> 255
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<400> 4551
Met Lys Leu Xaa Arg Lys Met Val Leu Xaa Arg Ala Lys Ala Ser Glu 
1               5                   10                  15      


Leu His Ser Val Arg Lys Leu Asn Cys Trp Gly Ser Arg Leu Xaa Asp 
            20                  25                  30          


Ile Ser Ile Cys Gln Glu Met Pro Ser Leu Glu Val Ile Xaa Leu Ser 
        35                  40                  45              


Val Asn Ser Ile Ser Xaa Leu Glu Pro Val Ser Arg Cys Gln Arg Leu 
    50                  55                  60                  


Ser Glu Leu Tyr Leu Arg Arg Asn Arg Ile Pro Ser Leu Ala Glu Leu 
65                  70                  75                  80  


Phe Tyr Leu Lys Gly Leu Pro Arg Leu Arg Val Leu Trp Leu Ala Glu 
                85                  90                  95      


Asn Pro Cys Cys Gly Xaa Ser Pro His Arg Tyr Arg Met Xaa Val Leu 
            100                 105                 110         


Arg Xaa Leu Pro Arg Leu Gln Lys Leu Asp Asn Gln Ala Val Xaa Glu 
        115                 120                 125             


Glu Glu Leu Ser Arg Ala Leu Ser Glu Gly Glu Glu Ile Xaa Ala Ala 
    130                 135                 140                 


Pro Glu Arg Glu Gly Xaa Gly His Gly Gly Pro Lys Leu Cys Cys Xaa 
145                 150                 155                 160 


Leu Ser Ser Leu Ser Ser Ala Ala Glu Xaa Gly Arg Asp Pro Leu Asp 
                165                 170                 175     


Ser Glu Glu Glu Ala Xaa Gly Ala Gln Asp Glu Arg Gly Leu Lys Pro 
            180                 185                 190         


Pro Ser Arg Gly Gln Phe Pro Ser Leu Ser Ala Arg Asp Ala Ser Ser 
        195                 200                 205             


Ser His Arg Gly Arg Asn Val Leu Xaa Ala Ile Leu Leu Leu Leu Arg 
    210                 215                 220                 


Glu Leu Asp Ala Glu Gly Leu Glu Ala Val Gln Gln Xaa Val Gly Ser 
225                 230                 235                 240 


Arg Leu Gln Ala Leu Arg Gly Glu Glu Val Gln Glu His Ala Glu 
                245                 250                 255 


<210> 4552
<211> 375
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<400> 4552
Met Lys Leu Xaa Arg Lys Met Val Leu Xaa Arg Ala Lys Ala Ser Glu 
1               5                   10                  15      


Leu His Ser Val Arg Lys Leu Asn Cys Trp Gly Ser Arg Leu Xaa Asp 
            20                  25                  30          


Ile Ser Ile Cys Gln Glu Met Pro Ser Leu Glu Val Ile Xaa Leu Ser 
        35                  40                  45              


Val Asn Ser Ile Ser Xaa Leu Glu Pro Val Ser Arg Cys Gln Arg Leu 
    50                  55                  60                  


Ser Glu Leu Tyr Leu Arg Arg Asn Arg Ile Pro Ser Leu Ala Glu Leu 
65                  70                  75                  80  


Phe Tyr Leu Lys Gly Leu Pro Arg Leu Arg Val Leu Trp Leu Ala Glu 
                85                  90                  95      


Asn Pro Cys Cys Gly Xaa Ser Pro His Arg Tyr Arg Met Xaa Val Leu 
            100                 105                 110         


Arg Xaa Leu Pro Arg Leu Gln Lys Leu Asp Asn Gln Ala Val Xaa Glu 
        115                 120                 125             


Glu Glu Leu Ser Arg Ala Leu Ser Glu Gly Glu Glu Ile Xaa Ala Ala 
    130                 135                 140                 


Pro Glu Arg Glu Gly Xaa Gly His Gly Gly Pro Lys Leu Cys Cys Xaa 
145                 150                 155                 160 


Leu Ser Ser Leu Ser Ser Ala Ala Glu Xaa Gly Arg Asp Pro Leu Asp 
                165                 170                 175     


Ser Glu Glu Glu Ala Xaa Gly Ala Gln Asp Glu Arg Gly Leu Lys Pro 
            180                 185                 190         


Pro Ser Arg Gly Gln Phe Pro Ser Leu Ser Ala Arg Asp Ala Ser Ser 
        195                 200                 205             


Ser His Arg Gly Arg Val Ser Gly Gly Pro Leu Gly Ala Ala Ala Ala 
    210                 215                 220                 


Ser Ala His Cys Xaa His Cys Xaa Glu Xaa Val Gly Arg Glu His Gly 
225                 230                 235                 240 


Ala Ser Gln Gly Pro Val Gly Arg Glu His Gly Ala Ser Gln Gly Leu 
                245                 250                 255     


Glu Glu Leu Cys Pro Arg Gly Ser Cys Val Cys Gly Ser Val Asn Ala 
            260                 265                 270         


His Xaa Arg Val Xaa Arg Ala Pro His Gly Ala Val Leu Ala Pro Gln 
        275                 280                 285             


Pro Leu Leu Leu Ser Trp Ser Val Glu Cys Gly Pro Gly Pro Cys Trp 
    290                 295                 300                 


Ala Glu Gly Asn Arg Ser His Val Glu Glu Val Pro His Xaa Arg Pro 
305                 310                 315                 320 


Gln Ala Gly Leu Leu Cys Ser Asp Ser Pro Ser Val Pro Asn Val Leu 
                325                 330                 335     


Xaa Ala Ile Leu Leu Leu Leu Arg Glu Leu Asp Ala Glu Gly Leu Glu 
            340                 345                 350         


Ala Val Gln Gln Xaa Val Gly Ser Arg Leu Gln Ala Leu Arg Gly Glu 
        355                 360                 365             


Glu Val Gln Glu His Ala Glu 
    370                 375 


<210> 4553
<211> 256
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<400> 4553
Met Lys Leu Xaa Arg Lys Met Val Leu Xaa Arg Ala Lys Ala Ser Glu 
1               5                   10                  15      


Leu His Ser Val Arg Lys Leu Asn Cys Trp Gly Ser Arg Leu Xaa Asp 
            20                  25                  30          


Ile Ser Ile Cys Gln Glu Met Pro Ser Leu Glu Val Ile Xaa Leu Ser 
        35                  40                  45              


Val Asn Ser Ile Ser Xaa Leu Glu Pro Val Ser Arg Cys Gln Arg Leu 
    50                  55                  60                  


Ser Glu Leu Tyr Leu Arg Arg Asn Arg Ile Pro Ser Leu Ala Glu Leu 
65                  70                  75                  80  


Phe Tyr Leu Lys Gly Leu Pro Arg Leu Arg Val Leu Trp Leu Ala Glu 
                85                  90                  95      


Asn Pro Cys Cys Gly Xaa Ser Pro His Arg Tyr Arg Met Xaa Val Leu 
            100                 105                 110         


Arg Xaa Leu Pro Arg Leu Gln Lys Leu Asp Asn Gln Ala Val Xaa Glu 
        115                 120                 125             


Glu Glu Leu Ser Arg Ala Leu Ser Glu Gly Glu Glu Ile Xaa Ala Ala 
    130                 135                 140                 


Pro Glu Arg Glu Gly Xaa Gly His Gly Gly Pro Lys Leu Cys Cys Xaa 
145                 150                 155                 160 


Leu Ser Ser Leu Ser Ser Ala Ala Glu Xaa Gly Arg Asp Pro Leu Asp 
                165                 170                 175     


Ser Glu Glu Glu Ala Xaa Ser Gly Ala Gln Asp Glu Arg Gly Leu Lys 
            180                 185                 190         


Pro Pro Ser Arg Gly Gln Phe Pro Ser Leu Ser Ala Arg Asp Ala Ser 
        195                 200                 205             


Ser Ser His Arg Gly Arg Asn Val Leu Xaa Ala Ile Leu Leu Leu Leu 
    210                 215                 220                 


Arg Glu Leu Asp Ala Glu Gly Leu Glu Ala Val Gln Gln Xaa Val Gly 
225                 230                 235                 240 


Ser Arg Leu Gln Ala Leu Arg Gly Glu Glu Val Gln Glu His Ala Glu 
                245                 250                 255     


<210> 4554
<211> 776
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<400> 4554
Ala Ala Arg Xaa Val Ser Ile Ser Val Gln Ile Ile Arg Ala Cys Gly 
1               5                   10                  15      


Leu Gln Ala Ala Ala Lys Ala Leu Ala Glu Arg Glu Pro Ala Leu Gln 
            20                  25                  30          


Phe Ser Ala Xaa Val Gly Val Asn Ala Ser Val Xaa Xaa His Leu Ser 
        35                  40                  45              


Phe Leu Pro Gln Gly Glu Gln Arg Arg Xaa His Pro Val Ala Cys Ser 
    50                  55                  60                  


Phe Cys Pro Glu Phe Ser His His Val Glu Phe Xaa Cys Asn Leu Val 
65                  70                  75                  80  


Xaa Gln His Cys Ser Gly Glu Ala Cys Phe Leu Ala Glu Leu Leu Glu 
                85                  90                  95      


Phe Ala Glu Val Ile Phe Ala Val Tyr His Glu Asn Xaa Lys Ser Ala 
            100                 105                 110         


Ser Asp Ile Ile Ser Ile Glu Ser Cys Lys Glu Tyr Leu Leu Gly Val 
        115                 120                 125             


Val Lys Val Pro Xaa Lys Glu Leu Leu Ile Lys Arg Ser Gly Ile Xaa 
    130                 135                 140                 


Gly Trp Tyr Pro Ile Ile Leu Pro Glu Asp Gly Gly Leu Pro His Gly 
145                 150                 155                 160 


Leu Glu Leu Met Gln Lys Ile Val Gly Gly Leu Glu Leu Ser Ile Ser 
                165                 170                 175     


Phe Xaa His Arg Gly Asp Arg Glu Arg Val Leu Glu Ala Ala Glu His 
            180                 185                 190         


Leu Gly Trp Ser Phe Glu Asn Ser Leu Lys Asp Phe Val Arg Met Asp 
        195                 200                 205             


Glu Gly Glu Pro Ala Xaa Val Xaa Ile Ser Xaa Pro Arg Leu Trp Leu 
    210                 215                 220                 


Pro Ile His Cys Val Leu Leu Ala Gly His Asn His Ile His Lys Asn 
225                 230                 235                 240 


Xaa Tyr Cys Tyr Leu Arg Tyr Lys Phe Tyr Asp His Glu Ala Phe Trp 
                245                 250                 255     


Xaa Pro Leu Lys Lys Pro Lys Glu Ser Val Asn Lys Lys Gln Ile Met 
            260                 265                 270         


Val Xaa Phe Lys Ala Ser Lys Arg Ala Glu Val Xaa Arg Gly Pro Ser 
        275                 280                 285             


Leu Leu Trp Tyr Phe Arg Glu Glu Arg Leu Glu Ile Gln Val Trp Arg 
    290                 295                 300                 


Ala Tyr Gly Asn Asp Ser Val Glu Arg Pro His Gln Xaa Asp Ser Trp 
305                 310                 315                 320 


Ile Gly Ser Ala Tyr Val Asp Leu Ala Arg Leu Gly Glu Arg Ser Ala 
                325                 330                 335     


Arg Xaa Leu Xaa Val Ser Gly Val Tyr Pro Leu Phe Gly Arg Asn Ala 
            340                 345                 350         


Ser Asn Leu Ser Gly Ala Ala Leu Arg Val His Val Val Leu Ser Ser 
        355                 360                 365             


Leu Ser Ser His Leu Glu Pro Xaa His Glu Leu Asp Ser Met Asp Cys 
    370                 375                 380                 


Ser Ser His Ser Glu Ser Glu Gln Leu Pro Arg Arg Asn Asp Glu Val 
385                 390                 395                 400 


Gln Leu Ser Pro Pro Glu Val Ile Ser Cys His Gln Lys Ser Pro Ala 
                405                 410                 415     


Ser Xaa Gln Val Pro Cys Ser Ser Xaa Xaa Ala Glu Val Arg Leu Xaa 
            420                 425                 430         


Gln Glu Gly Pro Ala Asp Leu Asp Gly Xaa Phe Ala Val Ser Ile Leu 
        435                 440                 445             


Val Glu Arg Ala Met His Leu Ser Leu Lys Gly Ser Pro Leu Xaa Glu 
    450                 455                 460                 


Arg Lys Val Ser Ile Pro Ser Cys Cys Val Ser Phe Ala Xaa Ala Asp 
465                 470                 475                 480 


Glu Ser Ser Pro Val Tyr Xaa Gln Val Val Glu Asn Xaa Asp Ser Pro 
                485                 490                 495     


Ile Trp Asn Phe Gln Gln Gln Ser Arg Leu Ser Lys Glu Leu Leu Leu 
            500                 505                 510         


Asp Pro Gln Gln Xaa Leu Val Phe Lys Val Trp His Lys Gly Asp Glu 
        515                 520                 525             


Glu Arg Val Ile Gly Phe Ala Ser Val Asp Leu Ser Pro Leu Leu Ser 
    530                 535                 540                 


Gly Phe Gln Phe Val Cys Gly Trp Tyr Asn Ile Xaa Asp Phe Ser Gly 
545                 550                 555                 560 


Glu Cys Gln Gly Gln Ile Lys Val Ala Val Ser Pro Leu Glu Ser Leu 
                565                 570                 575     


Ile His Phe Lys Glu Glu Arg Gln Ala Arg Arg Gly Val Glu Xaa Ser 
            580                 585                 590         


Lys Ser Leu Ile Pro Ile Tyr Ser Pro Phe Ser Phe Pro Ala Ser Asp 
        595                 600                 605             


Xaa Tyr Ala Ala Phe Ser Ser His Met Ala Arg Gln Xaa Leu Asp Gln 
    610                 615                 620                 


Leu Ala His Ala Ser Ser Lys Glu Leu Asp Phe Ser Ser Pro Gly Arg 
625                 630                 635                 640 


Ser Asp Xaa Xaa Arg Ser Gln Ala Ser Arg His Glu Glu His Val Gln 
                645                 650                 655     


Asn Ile Arg Arg Phe His Glu Ser Leu His Leu Gln Gly Glu Ala Pro 
            660                 665                 670         


Leu Pro Cys Asp Asp Lys Leu Xaa Xaa Ser Pro Leu Ser Ser Gln Xaa 
        675                 680                 685             


Ser Ile Leu Xaa Ser Leu Arg Lys Asn Leu Ser Glu Leu Asp Gln Ile 
    690                 695                 700                 


Gln Arg Tyr Phe Arg Gln Lys Leu Xaa Lys Pro Phe Leu Pro Leu Ser 
705                 710                 715                 720 


Pro Gln Xaa Gln Xaa Ala Ile Ser Gln His Gln Glu Ser Cys Arg Asp 
                725                 730                 735     


His Leu Gly Pro Gly Ala Ser Ser Leu Asp Pro Gly Ser Gln Cys Ile 
            740                 745                 750         


Leu Glu Lys Ser Ser Asn Leu Val Leu Gln Val Ser Ser Leu Ile Xaa 
        755                 760                 765             


Gly Leu Pro Ala Pro Asn Asp Ser 
    770                 775     


<210> 4555
<211> 677
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<400> 4555
Gly Glu Gln Arg Arg Xaa His Pro Val Ala Cys Ser Phe Cys Pro Glu 
1               5                   10                  15      


Phe Ser His His Val Glu Phe Xaa Cys Asn Leu Val Xaa Gln His Cys 
            20                  25                  30          


Ser Gly Glu Ala Cys Phe Leu Ala Glu Leu Leu Glu Phe Ala Glu Val 
        35                  40                  45              


Ile Phe Ala Val Tyr His Glu Asn Xaa Lys Ser Ala Ser Asp Ile Ile 
    50                  55                  60                  


Ser Ile Glu Ser Cys Lys Glu Tyr Leu Leu Gly Val Val Lys Val Pro 
65                  70                  75                  80  


Xaa Lys Glu Leu Leu Ile Lys Arg Ser Gly Ile Xaa Gly Trp Tyr Pro 
                85                  90                  95      


Ile Ile Leu Pro Glu Asp Gly Gly Leu Pro His Gly Leu Glu Leu Met 
            100                 105                 110         


Gln Lys Ile Val Gly Gly Leu Glu Leu Ser Ile Ser Phe Xaa His Arg 
        115                 120                 125             


Gly Asp Arg Glu Arg Val Leu Glu Ala Ala Glu His Leu Gly Trp Ser 
    130                 135                 140                 


Phe Glu Asn Ser Leu Lys Asp Phe Val Arg Met Asp Glu Gly Glu Pro 
145                 150                 155                 160 


Ala Xaa Val Xaa Ile Ser Xaa Pro Arg Leu Trp Leu Pro Ile His Cys 
                165                 170                 175     


Val Leu Leu Ala Gly His Asn His Ile His Lys Asn Xaa Tyr Cys Tyr 
            180                 185                 190         


Leu Arg Tyr Lys Phe Tyr Asp His Glu Ala Phe Trp Xaa Pro Leu Lys 
        195                 200                 205             


Lys Pro Lys Glu Ser Val Asn Lys Lys Gln Ile Met Val Xaa Phe Lys 
    210                 215                 220                 


Ala Ser Lys Arg Ala Glu Val Xaa Arg Gly Pro Ser Leu Leu Trp Tyr 
225                 230                 235                 240 


Phe Arg Glu Glu Arg Leu Glu Ile Gln Val Trp Arg Ala Tyr Gly Asn 
                245                 250                 255     


Asp Ser Val Glu Arg Pro His Gln Xaa Asp Ser Trp Ile Gly Ser Ala 
            260                 265                 270         


Tyr Val Asp Leu Ala Arg Leu Gly Glu Arg Ser Ala Arg Xaa Leu Xaa 
        275                 280                 285             


Val Ser Gly Val Tyr Pro Leu Phe Gly Arg Asn Ala Ser Asn Leu Ser 
    290                 295                 300                 


Gly Ala Ala Leu Arg Val His Val Val Leu Ser Ser Leu Ser Ser His 
305                 310                 315                 320 


Leu Glu Pro Xaa His Glu Leu Asp Ser Met Asp Cys Ser Ser His Ser 
                325                 330                 335     


Glu Ser Glu Gln Leu Pro Arg Arg Asn Asp Glu Val Gln Leu Ser Pro 
            340                 345                 350         


Pro Glu Val Ile Ser Cys His Gln Lys Ser Pro Ala Ser Xaa Gln Val 
        355                 360                 365             


Pro Cys Ser Ser Xaa Xaa Ala Glu Val Arg Leu Xaa Gln Glu Gly Pro 
    370                 375                 380                 


Ala Asp Leu Asp Gly Xaa Phe Ala Val Ser Ile Leu Val Glu Arg Ala 
385                 390                 395                 400 


Met His Leu Ser Leu Lys Gly Ser Pro Leu Xaa Glu Arg Lys Val Ser 
                405                 410                 415     


Ile Pro Ser Cys Cys Val Ser Phe Ala Xaa Ala Asp Glu Ser Ser Pro 
            420                 425                 430         


Val Tyr Xaa Gln Val Val Glu Asn Xaa Asp Ser Pro Ile Trp Asn Phe 
        435                 440                 445             


Gln Gln Gln Ser Arg Leu Ser Lys Glu Leu Leu Leu Asp Pro Gln Gln 
    450                 455                 460                 


Xaa Leu Val Phe Lys Val Trp His Lys Gly Asp Glu Glu Arg Val Ile 
465                 470                 475                 480 


Gly Phe Ala Ser Val Asp Leu Ser Pro Leu Leu Ser Gly Phe Gln Phe 
                485                 490                 495     


Val Cys Gly Trp Tyr Asn Ile Xaa Asp Phe Ser Gly Glu Cys Gln Gly 
            500                 505                 510         


Gln Ile Lys Val Ala Val Ser Pro Leu Glu Ser Leu Ile His Phe Lys 
        515                 520                 525             


Glu Glu Arg Gln Ala Arg Arg Gly Val Glu Xaa Ser Lys Ser Leu Ile 
    530                 535                 540                 


Pro Ile Tyr Ser Pro Phe Ser Phe Pro Ala Ser Asp Xaa Tyr Ala Ala 
545                 550                 555                 560 


Phe Ser Ser His Met Ala Arg Gln Xaa Leu Asp Gln Leu Ala His Ala 
                565                 570                 575     


Ser Ser Lys Glu Leu Asp Phe Ser Ser Pro Gly Arg Ser Asp Xaa Xaa 
            580                 585                 590         


Arg Ser Gln Ala Ser Arg His Glu Glu His Val Gln Asn Ile Arg Arg 
        595                 600                 605             


Phe His Glu Ser Leu His Leu Gln Gly Glu Ala Pro Leu Pro Cys Asp 
    610                 615                 620                 


Asp Lys Leu Xaa Xaa Ser Pro Leu Ser Ser Gln Xaa Ser Ile Leu Xaa 
625                 630                 635                 640 


Ser Leu Arg Ser Ser Pro Ser Leu Ser Tyr Pro Ser Ala Leu Arg Leu 
                645                 650                 655     


Lys Arg Pro Ser His Ser Xaa Arg Arg Ala Val Gly Xaa Ile Leu Gly 
            660                 665                 670         


Gln Val Pro Ala Ala 
        675         


<210> 4556
<211> 506
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<400> 4556
Met Lys Gln Arg Lys Gly Gln Gly Ser Gly Gly Ser Arg Gly Arg Lys 
1               5                   10                  15      


Lys Arg Gly Leu Ser Asp Ile Ser Pro Ser Xaa Ser Leu Pro Pro Leu 
            20                  25                  30          


Val Glu Gly Gln Leu Arg Cys Phe Leu Lys Leu Xaa Val Asn Arg Val 
        35                  40                  45              


Ile Trp Lys Ile Ala Lys Pro Pro Xaa Cys Val Leu Val Arg Val Arg 
    50                  55                  60                  


Trp Trp Gly Glu Xaa Ser Asp Gly Xaa Leu Phe Cys Pro Arg Asp Ala 
65                  70                  75                  80  


Leu Gln Xaa Glu Pro Lys Ala Val Arg Xaa Xaa Xaa Arg Tyr Ala Ile 
                85                  90                  95      


Arg Cys Gly Pro Lys Gln Phe Xaa Ser Tyr Leu Xaa Asp Met Ala Val 
            100                 105                 110         


Leu Val Leu Glu Val Ile Xaa Lys Leu Asp Gly Leu Pro Ile Gly Arg 
        115                 120                 125             


Val Gln Ile Asn Gly Leu Ala Gln Leu Ser Pro Xaa His Gln Ile Asn 
    130                 135                 140                 


Gly Phe Phe Xaa Ile Val Ser Ser Xaa Ser Lys Lys Leu Gly Glu Leu 
145                 150                 155                 160 


Gln Val Ser Leu Ala Leu Glu Pro Leu Ser Glu Xaa Tyr Asp Ser Tyr 
                165                 170                 175     


His Pro Leu Pro Xaa Xaa Asp Met Xaa Glu Asn Val Leu Leu Ser Lys 
            180                 185                 190         


Gln Gly Phe Arg Glu Asn Xaa Glu Pro Ser Ser Xaa Gln Phe Gln Val 
        195                 200                 205             


Pro Ser Arg Pro Arg Asp Ile His Xaa Ile Lys Ile Asp Gly Lys Glu 
    210                 215                 220                 


Leu Ala Ala Asn Ser Ser Arg Ser Xaa Xaa Pro Arg Gly Lys Asp His 
225                 230                 235                 240 


Val Cys Phe Ala Glu Asn Pro Asp Xaa Ile Lys Asp Ser Ser Phe Gly 
                245                 250                 255     


Leu Gln His Ser Leu Asn Ser Gly Gln Ser Leu Glu Ser Val Xaa Leu 
            260                 265                 270         


Lys Gly Arg Ala Pro Arg Lys Gln Met Ser Leu Leu Asn Ser Ser Glu 
        275                 280                 285             


Phe Gln Pro Gln Ile Arg Xaa Val Ala Lys Ser His Ser Asp Ser Cys 
    290                 295                 300                 


Ile Leu Ser Ser Asn Asn Leu Pro Xaa Lys Asp Leu Leu Ser Ala Leu 
305                 310                 315                 320 


Leu Glu Gln Gly Asn Lys Leu Arg Asn Ala Met Val Ile Ser Ala Met 
                325                 330                 335     


Lys Ser Ser Pro Glu Xaa Ser Met Leu Leu Asp Gln Val His Pro Pro 
            340                 345                 350         


Ile Asn Glu Asp Ser Leu Arg Ala Ser Xaa Gln Ile Arg Ala Phe Ser 
        355                 360                 365             


Arg Asn Arg Phe Lys Asp His Ile Glu Asp His Leu Leu Pro Ser Xaa 
    370                 375                 380                 


Glu Asn Xaa Phe Trp Arg His Asp Xaa Lys Ala Asp Xaa Arg Ala Ile 
385                 390                 395                 400 


Gln Leu Leu Leu Gly Ser Leu Gly Leu Xaa Arg Cys Arg Asp Cys Arg 
                405                 410                 415     


Arg Ser Leu Val His Ala Val Leu Asn Gly Ala Gln Ala Gly Val Gln 
            420                 425                 430         


Trp Arg Asp Ile Gly Ser Leu Gln Pro Pro Pro Pro Ser Arg Leu Pro 
        435                 440                 445             


Trp Pro Pro Lys Val Pro Arg Leu Gln Pro Leu Pro Gly Arg His Pro 
    450                 455                 460                 


Val Trp Glu Val Arg Ser Val Ser Ala Trp Pro Pro Ile Val Trp Asp 
465                 470                 475                 480 


Val Arg Ile Pro Ser Ala Trp Leu Pro Ser Leu Glu Ser Glu Glu Arg 
                485                 490                 495     


Leu Cys Pro Pro Ala Ile Pro Ser Arg Lys 
            500                 505     


<210> 4557
<211> 1963
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1152)..(1152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1187)..(1187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1268)..(1268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1273)..(1273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1325)..(1325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1406)..(1406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1411)..(1411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1433)..(1433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1449)..(1449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1466)..(1466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1476)..(1476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1509)..(1509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1530)..(1530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1532)..(1532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1610)..(1610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1617)..(1618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1624)..(1624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1634)..(1634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1655)..(1655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1670)..(1670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1679)..(1679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1685)..(1685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1709)..(1709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1748)..(1748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1783)..(1783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1801)..(1801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1813)..(1813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1835)..(1836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1872)..(1873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1880)..(1880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1884)..(1884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1905)..(1905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1915)..(1915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1917)..(1917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1960)..(1960)
<223> Selenocysteine

<400> 4557
Met Lys Gln Arg Lys Gly Gln Gly Ser Gly Gly Ser Arg Gly Arg Lys 
1               5                   10                  15      


Lys Arg Gly Leu Ser Asp Ile Ser Pro Ser Xaa Ser Leu Pro Pro Leu 
            20                  25                  30          


Val Glu Gly Gln Leu Arg Cys Phe Leu Lys Leu Xaa Val Asn Arg Val 
        35                  40                  45              


Ile Trp Lys Ile Ala Lys Pro Pro Xaa Cys Val Leu Val Arg Val Arg 
    50                  55                  60                  


Trp Trp Gly Glu Xaa Ser Asp Gly Xaa Leu Phe Cys Pro Arg Asp Ala 
65                  70                  75                  80  


Leu Gln Xaa Glu Pro Lys Ala Val Arg Xaa Xaa Xaa Arg Tyr Ala Ile 
                85                  90                  95      


Arg Cys Gly Pro Lys Gln Phe Xaa Ser Tyr Leu Xaa Asp Met Ala Val 
            100                 105                 110         


Leu Val Leu Glu Val Ile Xaa Lys Leu Asp Gly Leu Pro Ile Gly Arg 
        115                 120                 125             


Val Gln Ile Asn Gly Leu Ala Gln Leu Ser Pro Xaa His Gln Ile Asn 
    130                 135                 140                 


Gly Phe Phe Xaa Ile Val Ser Ser Xaa Ser Lys Lys Leu Gly Glu Leu 
145                 150                 155                 160 


Gln Val Ser Leu Ala Leu Glu Pro Leu Ser Glu Xaa Tyr Asp Ser Tyr 
                165                 170                 175     


His Pro Leu Pro Xaa Xaa Asp Met Xaa Glu Asn Val Leu Leu Ser Lys 
            180                 185                 190         


Gln Gly Phe Arg Glu Asn Xaa Glu Pro Ser Ser Xaa Gln Phe Gln Val 
        195                 200                 205             


Pro Ser Arg Pro Arg Asp Ile His Xaa Ile Lys Ile Asp Gly Lys Glu 
    210                 215                 220                 


Leu Ala Ala Asn Ser Ser Arg Ser Xaa Xaa Pro Arg Gly Lys Asp His 
225                 230                 235                 240 


Val Cys Phe Ala Glu Asn Pro Asp Xaa Ile Lys Asp Ser Ser Phe Gly 
                245                 250                 255     


Leu Gln His Ser Leu Asn Ser Gly Gln Ser Leu Glu Ser Val Xaa Leu 
            260                 265                 270         


Lys Gly Arg Ala Pro Arg Lys Gln Met Ser Leu Leu Asn Ser Ser Glu 
        275                 280                 285             


Phe Gln Pro Gln Ile Arg Xaa Val Ala Lys Ser His Ser Asp Ser Cys 
    290                 295                 300                 


Ile Leu Ser Ser Asn Asn Leu Pro Xaa Lys Asp Leu Leu Ser Ala Leu 
305                 310                 315                 320 


Leu Glu Gln Gly Asn Lys Leu Arg Asn Ala Met Val Ile Ser Ala Met 
                325                 330                 335     


Lys Ser Ser Pro Glu Xaa Ser Met Leu Leu Asp Gln Val His Pro Pro 
            340                 345                 350         


Ile Asn Glu Asp Ser Leu Arg Ala Ser Xaa Gln Ile Arg Ala Phe Ser 
        355                 360                 365             


Arg Asn Arg Phe Lys Asp His Ile Glu Asp His Leu Leu Pro Ser Xaa 
    370                 375                 380                 


Glu Asn Xaa Phe Trp Arg His Asp Xaa Lys Ala Asp Xaa Arg Ala Ile 
385                 390                 395                 400 


Gln Leu Leu Leu Gly Ser Ala Glu Leu Ser Gln Gly Asn Phe Trp Asp 
                405                 410                 415     


Gly Leu Gly Ser Pro Pro Asp Ser Pro Ser Pro Gly Ser Asp Val Tyr 
            420                 425                 430         


Cys Ile Ser Glu Leu Asn Asp Pro Gln Tyr Asp Gln Ser Leu Leu Glu 
        435                 440                 445             


Asn Leu Phe Tyr Xaa Ala Pro Lys Ser Asp Xaa Ser Ile Ser Asp Phe 
    450                 455                 460                 


Leu Ser Glu Glu Asp Asp Ile Val Pro Ser Lys Lys Ile Ser Gln Ser 
465                 470                 475                 480 


Xaa Ala Leu Ala Arg Ser Ser Lys Val Leu Glu Ser Ser Asp His Lys 
                485                 490                 495     


Leu Lys Lys Arg Ser Ala Gly Lys Arg Asn Arg Asn Leu Val Glu Gln 
            500                 505                 510         


Gln Met Leu Ser Glu Xaa Pro Glu Asp Ala Gln Xaa Met Xaa Leu Ser 
        515                 520                 525             


Val Asp Arg Leu Ala Leu Leu Gly Arg Xaa His Ser Val Arg Ile Ile 
    530                 535                 540                 


Ile Glu Xaa Met Gly Val Pro Pro Asp Ser Pro Gln Met Xaa Pro Gly 
545                 550                 555                 560 


Lys Lys Ser Tyr Ala Gly Pro Pro Pro Lys Val Xaa Xaa Ala Lys Lys 
                565                 570                 575     


Arg Xaa Phe Phe Val Glu Tyr His Phe Pro Val Gly Phe Ser Glu Ser 
            580                 585                 590         


Gly Leu Gly Lys Xaa Ala Leu Ile Xaa Glu Val Val Arg Leu Ala Ser 
        595                 600                 605             


Ser Lys Ile Xaa Asp Gly Lys Val Lys Phe Gln Gln Arg Phe Val Phe 
    610                 615                 620                 


Pro Val Gln Phe Gly Gly Pro Met Ile Glu His Trp Trp Asn Ser Asn 
625                 630                 635                 640 


Leu Xaa Phe Gln Ile Tyr Val Lys Lys Xaa Pro Gln Lys Lys Pro Glu 
                645                 650                 655     


Val Ile Gly Ser Val Ser Leu Ser Leu Arg Ala Val Ile Gln Ser Glu 
            660                 665                 670         


Leu Leu Ser Phe Ser Asp Gln Leu Pro Val Gln Gln Glu Asn Gly Gln 
        675                 680                 685             


Ser Pro Phe Gly Pro Leu Lys Val Xaa Met Glu Leu Ile Xaa Asp Asn 
    690                 695                 700                 


Lys Asp Phe Xaa Gly Ile Asn Xaa Lys Leu Ser Gly Asn Xaa His Tyr 
705                 710                 715                 720 


Xaa Pro Leu Cys Ala Pro Xaa Ser Pro Asn Lys Ala Leu Pro Glu Leu 
                725                 730                 735     


Asn Gln Asp Met Xaa Cys Xaa Lys Asn Pro Gln Asn Leu Asn Gln Ile 
            740                 745                 750         


His Glu Glu Xaa Ala Lys Lys Ala Gln Asn Leu Val Leu Pro Asn Arg 
        755                 760                 765             


Lys Ser Pro Ser Pro Val Ala Pro His Pro Ser Xaa Phe Val Ala Xaa 
    770                 775                 780                 


Pro Ala Ser His Asn Leu Val Asn Gln Xaa Asn Gly Xaa Xaa Lys Glu 
785                 790                 795                 800 


Ser Ala Leu Leu Leu His Val Leu Leu Met Val Pro Asp Gly Lys Asp 
                805                 810                 815     


Phe Ile Ser Gly Glu Ser Glu Lys Gln Ser Pro Cys Asn Val Tyr Leu 
            820                 825                 830         


Asn Cys Lys Leu Phe Ser Xaa Glu Glu Val Xaa Arg Ser Val Ile Ala 
        835                 840                 845             


Trp Gly Xaa Xaa Gln Pro Val Phe Asn Phe Ser Gln Val Ile Pro Val 
    850                 855                 860                 


Ser Leu Ser Ser Lys Tyr Leu Glu Arg Leu Lys Asn Asn Val Met Val 
865                 870                 875                 880 


Ile Glu Xaa Trp Asn Lys Val Arg Ser Pro Gly Gln Asp Lys Leu Leu 
                885                 890                 895     


Gly Leu Val Lys Leu Pro Leu His Gln Phe Tyr Met Ser Phe Lys Asp 
            900                 905                 910         


Ala Lys Ile Ser Arg Leu Leu Leu Asp Ala Gln Tyr Pro Val Val Ala 
        915                 920                 925             


Val Asp Ser Tyr Met Pro Val Ile Asp Val Phe Ser Gly His Gln Asn 
    930                 935                 940                 


Gly Ser Leu Arg Val Phe Leu Ala Met Gly Ser Ser Asn Gln Ile Met 
945                 950                 955                 960 


Ala Leu Gln Arg Leu Lys Asn Glu Glu Gly Xaa Leu Pro Pro Phe Ser 
                965                 970                 975     


Pro Arg Pro Ala His Phe Leu Asp Gln Pro Xaa Ala Ala Ser Val Ala 
            980                 985                 990         


Met Ala Glu Asp Arg Gly Asn Gly  Leu Met Glu His Cys  Phe Glu Ile 
        995                 1000                 1005             


His Ile  Glu Met Val Lys Gly  Leu Ala Pro Leu Gln  Ala Xaa Val 
    1010                 1015                 1020             


Trp Gly  Glu Ala Asp Cys Tyr  Val Gln Tyr Tyr Phe  Pro Val Gln 
    1025                 1030                 1035             


His Ser  Gln Ser Ser Val Leu  Lys Gly Pro Glu Phe  Leu Glu Asn 
    1040                 1045                 1050             


Gly Ile  Xaa Leu Lys Pro Phe  Arg Xaa Ala Xaa Xaa  Leu Cys Val 
    1055                 1060                 1065             


Pro Asp  Pro Ile Phe Asn Ser  Glu His His His Ser  Leu Leu Leu 
    1070                 1075                 1080             


Pro Ala  Glu Val Pro Val Gln  Arg Leu Leu Leu Ser  Ala Phe Ser 
    1085                 1090                 1095             


Ala Gln  Gly Leu Val Pro Gly  Gly Gly Val Gln Phe  Glu Ile Trp 
    1100                 1105                 1110             


Cys Arg  Tyr Tyr Tyr Pro Asn  Val Arg Asp Gln Lys  Val Ala Lys 
    1115                 1120                 1125             


Gly Xaa  Leu Pro Leu Ser Arg  Ile Cys Ala Met Val  Xaa Xaa Gln 
    1130                 1135                 1140             


His Arg  Glu Asp Val Gly Ile  Gln Xaa Phe Asn Leu  Pro Leu Xaa 
    1145                 1150                 1155             


Pro Arg  Ile Glu Asn Arg Lys  Glu Leu Arg Asn Gln  Ser Ser Gly 
    1160                 1165                 1170             


Leu Leu  Asp Val Gly Leu Arg  Tyr Arg Arg Ser Pro  Arg Xaa Ala 
    1175                 1180                 1185             


Glu Gly  Val Leu Ala Ala Arg  Xaa Val Ser Ile Ser  Val Gln Ile 
    1190                 1195                 1200             


Ile Arg  Ala Cys Gly Leu Gln  Ala Ala Ala Lys Ala  Leu Ala Glu 
    1205                 1210                 1215             


Arg Glu  Pro Ala Leu Gln Phe  Ser Ala Xaa Val Gly  Val Asn Ala 
    1220                 1225                 1230             


Ser Val  Xaa Xaa His Leu Ser  Phe Leu Pro Gln Gly  Glu Gln Arg 
    1235                 1240                 1245             


Arg Xaa  His Pro Val Ala Cys  Ser Phe Cys Pro Glu  Phe Ser His 
    1250                 1255                 1260             


His Val  Glu Phe Xaa Cys Asn  Leu Val Xaa Gln His  Cys Ser Gly 
    1265                 1270                 1275             


Glu Ala  Cys Phe Leu Ala Glu  Leu Leu Glu Phe Ala  Glu Val Ile 
    1280                 1285                 1290             


Phe Ala  Val Tyr His Glu Asn  Xaa Lys Ser Ala Ser  Asp Ile Ile 
    1295                 1300                 1305             


Ser Ile  Glu Ser Cys Lys Glu  Tyr Leu Leu Gly Val  Val Lys Val 
    1310                 1315                 1320             


Pro Xaa  Lys Glu Leu Leu Ile  Lys Arg Ser Gly Ile  Xaa Gly Trp 
    1325                 1330                 1335             


Tyr Pro  Ile Ile Leu Pro Glu  Asp Gly Gly Leu Pro  His Gly Leu 
    1340                 1345                 1350             


Glu Leu  Met Gln Lys Ile Val  Gly Gly Leu Glu Leu  Ser Ile Ser 
    1355                 1360                 1365             


Phe Xaa  His Arg Gly Asp Arg  Glu Arg Val Leu Glu  Ala Ala Glu 
    1370                 1375                 1380             


His Leu  Gly Trp Ser Phe Glu  Asn Ser Leu Lys Asp  Phe Val Arg 
    1385                 1390                 1395             


Met Asp  Glu Gly Glu Pro Ala  Xaa Val Xaa Ile Ser  Xaa Pro Arg 
    1400                 1405                 1410             


Leu Trp  Leu Pro Ile His Cys  Val Leu Leu Ala Gly  His Asn His 
    1415                 1420                 1425             


Ile His  Lys Asn Xaa Tyr Cys  Tyr Leu Arg Tyr Lys  Phe Tyr Asp 
    1430                 1435                 1440             


His Glu  Ala Phe Trp Xaa Pro  Leu Lys Lys Pro Lys  Glu Ser Val 
    1445                 1450                 1455             


Asn Lys  Lys Gln Ile Met Val  Xaa Phe Lys Ala Ser  Lys Arg Ala 
    1460                 1465                 1470             


Glu Val  Xaa Arg Gly Pro Ser  Leu Leu Trp Tyr Phe  Arg Glu Glu 
    1475                 1480                 1485             


Arg Leu  Glu Ile Gln Val Trp  Arg Ala Tyr Gly Asn  Asp Ser Val 
    1490                 1495                 1500             


Glu Arg  Pro His Gln Xaa Asp  Ser Trp Ile Gly Ser  Ala Tyr Val 
    1505                 1510                 1515             


Asp Leu  Ala Arg Leu Gly Glu  Arg Ser Ala Arg Xaa  Leu Xaa Val 
    1520                 1525                 1530             


Ser Gly  Val Tyr Pro Leu Phe  Gly Arg Asn Ala Ser  Asn Leu Ser 
    1535                 1540                 1545             


Gly Ala  Ala Leu Arg Val His  Val Val Leu Ser Ser  Leu Ser Ser 
    1550                 1555                 1560             


His Leu  Glu Pro Xaa His Glu  Leu Asp Ser Met Asp  Cys Ser Ser 
    1565                 1570                 1575             


His Ser  Glu Ser Glu Gln Leu  Pro Arg Arg Asn Asp  Glu Val Gln 
    1580                 1585                 1590             


Leu Ser  Pro Pro Glu Val Ile  Ser Cys His Gln Lys  Ser Pro Ala 
    1595                 1600                 1605             


Ser Xaa  Gln Val Pro Cys Ser  Ser Xaa Xaa Ala Glu  Val Arg Leu 
    1610                 1615                 1620             


Xaa Gln  Glu Gly Pro Ala Asp  Leu Asp Gly Xaa Phe  Ala Val Ser 
    1625                 1630                 1635             


Ile Leu  Val Glu Arg Ala Met  His Leu Ser Leu Lys  Gly Ser Pro 
    1640                 1645                 1650             


Leu Xaa  Glu Arg Lys Val Ser  Ile Pro Ser Cys Cys  Val Ser Phe 
    1655                 1660                 1665             


Ala Xaa  Ala Asp Glu Ser Ser  Pro Val Tyr Xaa Gln  Val Val Glu 
    1670                 1675                 1680             


Asn Xaa  Asp Ser Pro Ile Trp  Asn Phe Gln Gln Gln  Ser Arg Leu 
    1685                 1690                 1695             


Ser Lys  Glu Leu Leu Leu Asp  Pro Gln Gln Xaa Leu  Val Phe Lys 
    1700                 1705                 1710             


Val Trp  His Lys Gly Asp Glu  Glu Arg Val Ile Gly  Phe Ala Ser 
    1715                 1720                 1725             


Val Asp  Leu Ser Pro Leu Leu  Ser Gly Phe Gln Phe  Val Cys Gly 
    1730                 1735                 1740             


Trp Tyr  Asn Ile Xaa Asp Phe  Ser Gly Glu Cys Gln  Gly Gln Ile 
    1745                 1750                 1755             


Lys Val  Ala Val Ser Pro Leu  Glu Ser Leu Ile His  Phe Lys Glu 
    1760                 1765                 1770             


Glu Arg  Gln Ala Arg Arg Gly  Val Glu Xaa Ser Lys  Ser Leu Ile 
    1775                 1780                 1785             


Pro Ile  Tyr Ser Pro Phe Ser  Phe Pro Ala Ser Asp  Xaa Tyr Ala 
    1790                 1795                 1800             


Ala Phe  Ser Ser His Met Ala  Arg Gln Xaa Leu Asp  Gln Leu Ala 
    1805                 1810                 1815             


His Ala  Ser Ser Lys Glu Leu  Asp Phe Ser Ser Pro  Gly Arg Ser 
    1820                 1825                 1830             


Asp Xaa  Xaa Arg Ser Gln Ala  Ser Arg His Glu Glu  His Val Gln 
    1835                 1840                 1845             


Asn Ile  Arg Arg Phe His Glu  Ser Leu His Leu Gln  Gly Glu Ala 
    1850                 1855                 1860             


Pro Leu  Pro Cys Asp Asp Lys  Leu Xaa Xaa Ser Pro  Leu Ser Ser 
    1865                 1870                 1875             


Gln Xaa  Ser Ile Leu Xaa Ser  Leu Arg Lys Asn Leu  Ser Glu Leu 
    1880                 1885                 1890             


Asp Gln  Ile Gln Arg Tyr Phe  Arg Gln Lys Leu Xaa  Lys Pro Phe 
    1895                 1900                 1905             


Leu Pro  Leu Ser Pro Gln Xaa  Gln Xaa Ala Ile Ser  Gln His Gln 
    1910                 1915                 1920             


Glu Ser  Cys Arg Asp His Leu  Gly Pro Gly Ala Ser  Ser Leu Asp 
    1925                 1930                 1935             


Pro Gly  Ser Gln Cys Ile Leu  Glu Lys Ser Ser Asn  Leu Val Leu 
    1940                 1945                 1950             


Gln Val  Ser Ser Leu Ile Xaa  Gly Ser Tyr 
    1955                 1960             


<210> 4558
<211> 2353
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1152)..(1152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1187)..(1187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1268)..(1268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1273)..(1273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1325)..(1325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1406)..(1406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1411)..(1411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1433)..(1433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1449)..(1449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1466)..(1466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1476)..(1476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1509)..(1509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1530)..(1530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1532)..(1532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1610)..(1610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1617)..(1618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1624)..(1624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1634)..(1634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1655)..(1655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1670)..(1670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1679)..(1679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1685)..(1685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1709)..(1709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1748)..(1748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1783)..(1783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1801)..(1801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1813)..(1813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1835)..(1836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1872)..(1873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1880)..(1880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1884)..(1884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1905)..(1905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1915)..(1915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1917)..(1917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1960)..(1960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1964)..(1964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1966)..(1966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1986)..(1987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1994)..(1994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2002)..(2002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2016)..(2016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2027)..(2027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2045)..(2045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2053)..(2053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2073)..(2073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2078)..(2079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2081)..(2081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2084)..(2084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2094)..(2094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2179)..(2179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2188)..(2188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2197)..(2197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2215)..(2215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2257)..(2258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2262)..(2262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2264)..(2264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2298)..(2298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2304)..(2305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2313)..(2313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2338)..(2338)
<223> Selenocysteine

<400> 4558
Met Lys Gln Arg Lys Gly Gln Gly Ser Gly Gly Ser Arg Gly Arg Lys 
1               5                   10                  15      


Lys Arg Gly Leu Ser Asp Ile Ser Pro Ser Xaa Ser Leu Pro Pro Leu 
            20                  25                  30          


Val Glu Gly Gln Leu Arg Cys Phe Leu Lys Leu Xaa Val Asn Arg Val 
        35                  40                  45              


Ile Trp Lys Ile Ala Lys Pro Pro Xaa Cys Val Leu Val Arg Val Arg 
    50                  55                  60                  


Trp Trp Gly Glu Xaa Ser Asp Gly Xaa Leu Phe Cys Pro Arg Asp Ala 
65                  70                  75                  80  


Leu Gln Xaa Glu Pro Lys Ala Val Arg Xaa Xaa Xaa Arg Tyr Ala Ile 
                85                  90                  95      


Arg Cys Gly Pro Lys Gln Phe Xaa Ser Tyr Leu Xaa Asp Met Ala Val 
            100                 105                 110         


Leu Val Leu Glu Val Ile Xaa Lys Leu Asp Gly Leu Pro Ile Gly Arg 
        115                 120                 125             


Val Gln Ile Asn Gly Leu Ala Gln Leu Ser Pro Xaa His Gln Ile Asn 
    130                 135                 140                 


Gly Phe Phe Xaa Ile Val Ser Ser Xaa Ser Lys Lys Leu Gly Glu Leu 
145                 150                 155                 160 


Gln Val Ser Leu Ala Leu Glu Pro Leu Ser Glu Xaa Tyr Asp Ser Tyr 
                165                 170                 175     


His Pro Leu Pro Xaa Xaa Asp Met Xaa Glu Asn Val Leu Leu Ser Lys 
            180                 185                 190         


Gln Gly Phe Arg Glu Asn Xaa Glu Pro Ser Ser Xaa Gln Phe Gln Val 
        195                 200                 205             


Pro Ser Arg Pro Arg Asp Ile His Xaa Ile Lys Ile Asp Gly Lys Glu 
    210                 215                 220                 


Leu Ala Ala Asn Ser Ser Arg Ser Xaa Xaa Pro Arg Gly Lys Asp His 
225                 230                 235                 240 


Val Cys Phe Ala Glu Asn Pro Asp Xaa Ile Lys Asp Ser Ser Phe Gly 
                245                 250                 255     


Leu Gln His Ser Leu Asn Ser Gly Gln Ser Leu Glu Ser Val Xaa Leu 
            260                 265                 270         


Lys Gly Arg Ala Pro Arg Lys Gln Met Ser Leu Leu Asn Ser Ser Glu 
        275                 280                 285             


Phe Gln Pro Gln Ile Arg Xaa Val Ala Lys Ser His Ser Asp Ser Cys 
    290                 295                 300                 


Ile Leu Ser Ser Asn Asn Leu Pro Xaa Lys Asp Leu Leu Ser Ala Leu 
305                 310                 315                 320 


Leu Glu Gln Gly Asn Lys Leu Arg Asn Ala Met Val Ile Ser Ala Met 
                325                 330                 335     


Lys Ser Ser Pro Glu Xaa Ser Met Leu Leu Asp Gln Val His Pro Pro 
            340                 345                 350         


Ile Asn Glu Asp Ser Leu Arg Ala Ser Xaa Gln Ile Arg Ala Phe Ser 
        355                 360                 365             


Arg Asn Arg Phe Lys Asp His Ile Glu Asp His Leu Leu Pro Ser Xaa 
    370                 375                 380                 


Glu Asn Xaa Phe Trp Arg His Asp Xaa Lys Ala Asp Xaa Arg Ala Ile 
385                 390                 395                 400 


Gln Leu Leu Leu Gly Ser Ala Glu Leu Ser Gln Gly Asn Phe Trp Asp 
                405                 410                 415     


Gly Leu Gly Ser Pro Pro Asp Ser Pro Ser Pro Gly Ser Asp Val Tyr 
            420                 425                 430         


Cys Ile Ser Glu Leu Asn Asp Pro Gln Tyr Asp Gln Ser Leu Leu Glu 
        435                 440                 445             


Asn Leu Phe Tyr Xaa Ala Pro Lys Ser Asp Xaa Ser Ile Ser Asp Phe 
    450                 455                 460                 


Leu Ser Glu Glu Asp Asp Ile Val Pro Ser Lys Lys Ile Ser Gln Ser 
465                 470                 475                 480 


Xaa Ala Leu Ala Arg Ser Ser Lys Val Leu Glu Ser Ser Asp His Lys 
                485                 490                 495     


Leu Lys Lys Arg Ser Ala Gly Lys Arg Asn Arg Asn Leu Val Glu Gln 
            500                 505                 510         


Gln Met Leu Ser Glu Xaa Pro Glu Asp Ala Gln Xaa Met Xaa Leu Ser 
        515                 520                 525             


Val Asp Arg Leu Ala Leu Leu Gly Arg Xaa His Ser Val Arg Ile Ile 
    530                 535                 540                 


Ile Glu Xaa Met Gly Val Pro Pro Asp Ser Pro Gln Met Xaa Pro Gly 
545                 550                 555                 560 


Lys Lys Ser Tyr Ala Gly Pro Pro Pro Lys Val Xaa Xaa Ala Lys Lys 
                565                 570                 575     


Arg Xaa Phe Phe Val Glu Tyr His Phe Pro Val Gly Phe Ser Glu Ser 
            580                 585                 590         


Gly Leu Gly Lys Xaa Ala Leu Ile Xaa Glu Val Val Arg Leu Ala Ser 
        595                 600                 605             


Ser Lys Ile Xaa Asp Gly Lys Val Lys Phe Gln Gln Arg Phe Val Phe 
    610                 615                 620                 


Pro Val Gln Phe Gly Gly Pro Met Ile Glu His Trp Trp Asn Ser Asn 
625                 630                 635                 640 


Leu Xaa Phe Gln Ile Tyr Val Lys Lys Xaa Pro Gln Lys Lys Pro Glu 
                645                 650                 655     


Val Ile Gly Ser Val Ser Leu Ser Leu Arg Ala Val Ile Gln Ser Glu 
            660                 665                 670         


Leu Leu Ser Phe Ser Asp Gln Leu Pro Val Gln Gln Glu Asn Gly Gln 
        675                 680                 685             


Ser Pro Phe Gly Pro Leu Lys Val Xaa Met Glu Leu Ile Xaa Asp Asn 
    690                 695                 700                 


Lys Asp Phe Xaa Gly Ile Asn Xaa Lys Leu Ser Gly Asn Xaa His Tyr 
705                 710                 715                 720 


Xaa Pro Leu Cys Ala Pro Xaa Ser Pro Asn Lys Ala Leu Pro Glu Leu 
                725                 730                 735     


Asn Gln Asp Met Xaa Cys Xaa Lys Asn Pro Gln Asn Leu Asn Gln Ile 
            740                 745                 750         


His Glu Glu Xaa Ala Lys Lys Ala Gln Asn Leu Val Leu Pro Asn Arg 
        755                 760                 765             


Lys Ser Pro Ser Pro Val Ala Pro His Pro Ser Xaa Phe Val Ala Xaa 
    770                 775                 780                 


Pro Ala Ser His Asn Leu Val Asn Gln Xaa Asn Gly Xaa Xaa Lys Glu 
785                 790                 795                 800 


Ser Ala Leu Leu Leu His Val Leu Leu Met Val Pro Asp Gly Lys Asp 
                805                 810                 815     


Phe Ile Ser Gly Glu Ser Glu Lys Gln Ser Pro Cys Asn Val Tyr Leu 
            820                 825                 830         


Asn Cys Lys Leu Phe Ser Xaa Glu Glu Val Xaa Arg Ser Val Ile Ala 
        835                 840                 845             


Trp Gly Xaa Xaa Gln Pro Val Phe Asn Phe Ser Gln Val Ile Pro Val 
    850                 855                 860                 


Ser Leu Ser Ser Lys Tyr Leu Glu Arg Leu Lys Asn Asn Val Met Val 
865                 870                 875                 880 


Ile Glu Xaa Trp Asn Lys Val Arg Ser Pro Gly Gln Asp Lys Leu Leu 
                885                 890                 895     


Gly Leu Val Lys Leu Pro Leu His Gln Phe Tyr Met Ser Phe Lys Asp 
            900                 905                 910         


Ala Lys Ile Ser Arg Leu Leu Leu Asp Ala Gln Tyr Pro Val Val Ala 
        915                 920                 925             


Val Asp Ser Tyr Met Pro Val Ile Asp Val Phe Ser Gly His Gln Asn 
    930                 935                 940                 


Gly Ser Leu Arg Val Phe Leu Ala Met Gly Ser Ser Asn Gln Ile Met 
945                 950                 955                 960 


Ala Leu Gln Arg Leu Lys Asn Glu Glu Gly Xaa Leu Pro Pro Phe Ser 
                965                 970                 975     


Pro Arg Pro Ala His Phe Leu Asp Gln Pro Xaa Ala Ala Ser Val Ala 
            980                 985                 990         


Met Ala Glu Asp Arg Gly Asn Gly  Leu Met Glu His Cys  Phe Glu Ile 
        995                 1000                 1005             


His Ile  Glu Met Val Lys Gly  Leu Ala Pro Leu Gln  Ala Xaa Val 
    1010                 1015                 1020             


Trp Gly  Glu Ala Asp Cys Tyr  Val Gln Tyr Tyr Phe  Pro Val Gln 
    1025                 1030                 1035             


His Ser  Gln Ser Ser Val Leu  Lys Gly Pro Glu Phe  Leu Glu Asn 
    1040                 1045                 1050             


Gly Ile  Xaa Leu Lys Pro Phe  Arg Xaa Ala Xaa Xaa  Leu Cys Val 
    1055                 1060                 1065             


Pro Asp  Pro Ile Phe Asn Ser  Glu His His His Ser  Leu Leu Leu 
    1070                 1075                 1080             


Pro Ala  Glu Val Pro Val Gln  Arg Leu Leu Leu Ser  Ala Phe Ser 
    1085                 1090                 1095             


Ala Gln  Gly Leu Val Pro Gly  Gly Gly Val Gln Phe  Glu Ile Trp 
    1100                 1105                 1110             


Cys Arg  Tyr Tyr Tyr Pro Asn  Val Arg Asp Gln Lys  Val Ala Lys 
    1115                 1120                 1125             


Gly Xaa  Leu Pro Leu Ser Arg  Ile Cys Ala Met Val  Xaa Xaa Gln 
    1130                 1135                 1140             


His Arg  Glu Asp Val Gly Ile  Gln Xaa Phe Asn Leu  Pro Leu Xaa 
    1145                 1150                 1155             


Pro Arg  Ile Glu Asn Arg Lys  Glu Leu Arg Asn Gln  Ser Ser Gly 
    1160                 1165                 1170             


Leu Leu  Asp Val Gly Leu Arg  Tyr Arg Arg Ser Pro  Arg Xaa Ala 
    1175                 1180                 1185             


Glu Gly  Val Leu Ala Ala Arg  Xaa Val Ser Ile Ser  Val Gln Ile 
    1190                 1195                 1200             


Ile Arg  Ala Cys Gly Leu Gln  Ala Ala Ala Lys Ala  Leu Ala Glu 
    1205                 1210                 1215             


Arg Glu  Pro Ala Leu Gln Phe  Ser Ala Xaa Val Gly  Val Asn Ala 
    1220                 1225                 1230             


Ser Val  Xaa Xaa His Leu Ser  Phe Leu Pro Gln Gly  Glu Gln Arg 
    1235                 1240                 1245             


Arg Xaa  His Pro Val Ala Cys  Ser Phe Cys Pro Glu  Phe Ser His 
    1250                 1255                 1260             


His Val  Glu Phe Xaa Cys Asn  Leu Val Xaa Gln His  Cys Ser Gly 
    1265                 1270                 1275             


Glu Ala  Cys Phe Leu Ala Glu  Leu Leu Glu Phe Ala  Glu Val Ile 
    1280                 1285                 1290             


Phe Ala  Val Tyr His Glu Asn  Xaa Lys Ser Ala Ser  Asp Ile Ile 
    1295                 1300                 1305             


Ser Ile  Glu Ser Cys Lys Glu  Tyr Leu Leu Gly Val  Val Lys Val 
    1310                 1315                 1320             


Pro Xaa  Lys Glu Leu Leu Ile  Lys Arg Ser Gly Ile  Xaa Gly Trp 
    1325                 1330                 1335             


Tyr Pro  Ile Ile Leu Pro Glu  Asp Gly Gly Leu Pro  His Gly Leu 
    1340                 1345                 1350             


Glu Leu  Met Gln Lys Ile Val  Gly Gly Leu Glu Leu  Ser Ile Ser 
    1355                 1360                 1365             


Phe Xaa  His Arg Gly Asp Arg  Glu Arg Val Leu Glu  Ala Ala Glu 
    1370                 1375                 1380             


His Leu  Gly Trp Ser Phe Glu  Asn Ser Leu Lys Asp  Phe Val Arg 
    1385                 1390                 1395             


Met Asp  Glu Gly Glu Pro Ala  Xaa Val Xaa Ile Ser  Xaa Pro Arg 
    1400                 1405                 1410             


Leu Trp  Leu Pro Ile His Cys  Val Leu Leu Ala Gly  His Asn His 
    1415                 1420                 1425             


Ile His  Lys Asn Xaa Tyr Cys  Tyr Leu Arg Tyr Lys  Phe Tyr Asp 
    1430                 1435                 1440             


His Glu  Ala Phe Trp Xaa Pro  Leu Lys Lys Pro Lys  Glu Ser Val 
    1445                 1450                 1455             


Asn Lys  Lys Gln Ile Met Val  Xaa Phe Lys Ala Ser  Lys Arg Ala 
    1460                 1465                 1470             


Glu Val  Xaa Arg Gly Pro Ser  Leu Leu Trp Tyr Phe  Arg Glu Glu 
    1475                 1480                 1485             


Arg Leu  Glu Ile Gln Val Trp  Arg Ala Tyr Gly Asn  Asp Ser Val 
    1490                 1495                 1500             


Glu Arg  Pro His Gln Xaa Asp  Ser Trp Ile Gly Ser  Ala Tyr Val 
    1505                 1510                 1515             


Asp Leu  Ala Arg Leu Gly Glu  Arg Ser Ala Arg Xaa  Leu Xaa Val 
    1520                 1525                 1530             


Ser Gly  Val Tyr Pro Leu Phe  Gly Arg Asn Ala Ser  Asn Leu Ser 
    1535                 1540                 1545             


Gly Ala  Ala Leu Arg Val His  Val Val Leu Ser Ser  Leu Ser Ser 
    1550                 1555                 1560             


His Leu  Glu Pro Xaa His Glu  Leu Asp Ser Met Asp  Cys Ser Ser 
    1565                 1570                 1575             


His Ser  Glu Ser Glu Gln Leu  Pro Arg Arg Asn Asp  Glu Val Gln 
    1580                 1585                 1590             


Leu Ser  Pro Pro Glu Val Ile  Ser Cys His Gln Lys  Ser Pro Ala 
    1595                 1600                 1605             


Ser Xaa  Gln Val Pro Cys Ser  Ser Xaa Xaa Ala Glu  Val Arg Leu 
    1610                 1615                 1620             


Xaa Gln  Glu Gly Pro Ala Asp  Leu Asp Gly Xaa Phe  Ala Val Ser 
    1625                 1630                 1635             


Ile Leu  Val Glu Arg Ala Met  His Leu Ser Leu Lys  Gly Ser Pro 
    1640                 1645                 1650             


Leu Xaa  Glu Arg Lys Val Ser  Ile Pro Ser Cys Cys  Val Ser Phe 
    1655                 1660                 1665             


Ala Xaa  Ala Asp Glu Ser Ser  Pro Val Tyr Xaa Gln  Val Val Glu 
    1670                 1675                 1680             


Asn Xaa  Asp Ser Pro Ile Trp  Asn Phe Gln Gln Gln  Ser Arg Leu 
    1685                 1690                 1695             


Ser Lys  Glu Leu Leu Leu Asp  Pro Gln Gln Xaa Leu  Val Phe Lys 
    1700                 1705                 1710             


Val Trp  His Lys Gly Asp Glu  Glu Arg Val Ile Gly  Phe Ala Ser 
    1715                 1720                 1725             


Val Asp  Leu Ser Pro Leu Leu  Ser Gly Phe Gln Phe  Val Cys Gly 
    1730                 1735                 1740             


Trp Tyr  Asn Ile Xaa Asp Phe  Ser Gly Glu Cys Gln  Gly Gln Ile 
    1745                 1750                 1755             


Lys Val  Ala Val Ser Pro Leu  Glu Ser Leu Ile His  Phe Lys Glu 
    1760                 1765                 1770             


Glu Arg  Gln Ala Arg Arg Gly  Val Glu Xaa Ser Lys  Ser Leu Ile 
    1775                 1780                 1785             


Pro Ile  Tyr Ser Pro Phe Ser  Phe Pro Ala Ser Asp  Xaa Tyr Ala 
    1790                 1795                 1800             


Ala Phe  Ser Ser His Met Ala  Arg Gln Xaa Leu Asp  Gln Leu Ala 
    1805                 1810                 1815             


His Ala  Ser Ser Lys Glu Leu  Asp Phe Ser Ser Pro  Gly Arg Ser 
    1820                 1825                 1830             


Asp Xaa  Xaa Arg Ser Gln Ala  Ser Arg His Glu Glu  His Val Gln 
    1835                 1840                 1845             


Asn Ile  Arg Arg Phe His Glu  Ser Leu His Leu Gln  Gly Glu Ala 
    1850                 1855                 1860             


Pro Leu  Pro Cys Asp Asp Lys  Leu Xaa Xaa Ser Pro  Leu Ser Ser 
    1865                 1870                 1875             


Gln Xaa  Ser Ile Leu Xaa Ser  Leu Arg Lys Asn Leu  Ser Glu Leu 
    1880                 1885                 1890             


Asp Gln  Ile Gln Arg Tyr Phe  Arg Gln Lys Leu Xaa  Lys Pro Phe 
    1895                 1900                 1905             


Leu Pro  Leu Ser Pro Gln Xaa  Gln Xaa Ala Ile Ser  Gln His Gln 
    1910                 1915                 1920             


Glu Ser  Cys Arg Asp His Leu  Gly Pro Gly Ala Ser  Ser Leu Asp 
    1925                 1930                 1935             


Pro Gly  Ser Gln Cys Ile Leu  Glu Lys Ser Ser Asn  Leu Val Leu 
    1940                 1945                 1950             


Gln Val  Ser Ser Leu Ile Xaa  Asp Leu Gln Xaa Ile  Xaa Arg Asp 
    1955                 1960                 1965             


Ser Gln  Ala Ala Leu Ser Ser  His Arg Ala Arg Ser  Arg Ser Asn 
    1970                 1975                 1980             


Lys Ala  Xaa Xaa Leu Pro Asp  Ala Gln Asp Xaa Glu  Ala Leu Gln 
    1985                 1990                 1995             


Glu Arg  Cys Xaa Met Pro Asp  Glu Pro Leu Val Arg  Ala Pro Asp 
    2000                 2005                 2010             


Lys Gly  Xaa Asp Ser Pro Ser  Pro Pro Pro Leu Glu  Glu Xaa Ser 
    2015                 2020                 2025             


Asn Gly  Gly Arg Met Leu His  Glu Ser Leu Arg His  Ala Val Pro 
    2030                 2035                 2040             


Ile Xaa  Arg Met Gln Ser Ser  Glu Asp Xaa Glu Ala  Gly Pro Ala 
    2045                 2050                 2055             


Tyr Ser  Asp Glu Asp Tyr Glu  Glu Asp Ile Ile Glu  Pro Arg Xaa 
    2060                 2065                 2070             


Leu Asn  Glu Ile Xaa Xaa Val  Xaa Asp Lys Xaa Ser  Pro Trp Ser 
    2075                 2080                 2085             


Ser Val  Ile Ser Asp Xaa Ser  Glu Val Ile Ser Pro  Gln Pro Asp 
    2090                 2095                 2100             


Glu Val  Gln Arg Glu Gly Pro  Ser Cys Pro Ser Pro  Gly Pro Phe 
    2105                 2110                 2115             


Cys Arg  Glu Glu Leu Met Val  Lys Ser Ser Phe Leu  Ser Ser Pro 
    2120                 2125                 2130             


Glu Arg  Ala Val Asn Pro His  Leu Pro Arg Gln Gly  Ser Pro Ser 
    2135                 2140                 2145             


Gln Ser  Leu Val Ala Cys Glu  Cys Glu Ala Ser Lys  Ala Arg Val 
    2150                 2155                 2160             


Gly Gly  Glu Ser Ala Ser Ala  Asn Pro Gln Pro Ile  Pro Cys Pro 
    2165                 2170                 2175             


Xaa Leu  Ser Gly Ala Gln Gln  Ser Ser Xaa Phe Val  Gly Trp Ser 
    2180                 2185                 2190             


Ser Pro  Gln Xaa Asp Gln Asn  Lys Glu Pro Lys Ser  Glu Ala Pro 
    2195                 2200                 2205             


Ala Glu  Asn Glu Ala Ala Xaa  Ser Glu Leu Gly Asp  Ser Ala Asp 
    2210                 2215                 2220             


Ser Phe  Lys Lys Leu Pro Leu  Asn Leu Ala Ser Gln  Ser Arg Arg 
    2225                 2230                 2235             


Glu Asn  His Lys Gly Pro Pro  Ile Asp Ser Ser Asp  Ile Arg Gln 
    2240                 2245                 2250             


Arg Gln  Val Xaa Xaa Gly Ser  Glu Xaa Ser Xaa Lys  Gln Ser Leu 
    2255                 2260                 2265             


Leu Leu  Pro Gly Pro Ile Val  Val Pro Asn Phe Phe  Leu Pro Pro 
    2270                 2275                 2280             


Gln Gln  Leu Glu Ala Ser Leu  Arg Met Leu Ser Leu  Ser Ala Xaa 
    2285                 2290                 2295             


Leu Pro  Pro Ala Ala Xaa Xaa  Asp Gln Asp Lys Ser  Glu Ala Xaa 
    2300                 2305                 2310             


Arg Gly  Ala Leu Ser Gln Arg  Pro Cys Arg Pro Arg  Pro Asn Ser 
    2315                 2320                 2325             


Leu Pro  Leu Asn Leu Pro Glu  Glu Glu Xaa Leu Arg  Ile Ala Arg 
    2330                 2335                 2340             


Ile Phe  Ser Ser Gln Tyr Ser  Gln Lys Asp 
    2345                 2350             


<210> 4559
<211> 171
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<400> 4559
Xaa Leu Ile His Phe Lys Glu Glu Arg Gln Ala Arg Arg Gly Val Glu 
1               5                   10                  15      


Xaa Ser Lys Ser Leu Ile Pro Ile Tyr Ser Pro Phe Ser Phe Pro Ala 
            20                  25                  30          


Ser Asp Xaa Tyr Ala Ala Phe Ser Ser His Met Ala Arg Gln Xaa Leu 
        35                  40                  45              


Asp Gln Leu Ala His Ala Ser Ser Lys Glu Leu Asp Phe Ser Ser Pro 
    50                  55                  60                  


Gly Arg Ser Asp Xaa Xaa Arg Ser Gln Ala Ser Arg His Glu Glu His 
65                  70                  75                  80  


Val Gln Asn Ile Arg Arg Phe His Glu Ser Leu His Leu Gln Gly Glu 
                85                  90                  95      


Ala Pro Leu Pro Cys Asp Asp Lys Leu Xaa Xaa Ser Pro Leu Ser Ser 
            100                 105                 110         


Gln Xaa Ser Ile Leu Xaa Ser Leu Ser Pro Gln Xaa Gln Xaa Ala Ile 
        115                 120                 125             


Ser Gln His Gln Glu Ser Cys Arg Asp His Leu Gly Pro Gly Ala Ser 
    130                 135                 140                 


Ser Leu Asp Pro Gly Ser Gln Cys Ile Leu Glu Lys Ser Ser Asn Leu 
145                 150                 155                 160 


Val Leu Gln Val Ser Ser Leu Ile Xaa Asp Xaa 
                165                 170     


<210> 4560
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<400> 4560
Tyr Lys Gly Ser Trp Val Xaa Glu Tyr Glu Asn Ser Ala Asp Ser Arg 
1               5                   10                  15      


Leu Gly Xaa Arg Arg Leu Ser Pro Glu Gly Gly Ala Leu Phe Arg Ala 
            20                  25                  30          


Met His Pro Ala Gln Trp Ser Pro Gln Arg Ala His Pro Tyr Ala Leu 
        35                  40                  45              


Ala Gln Leu Glu Ala Pro Pro Ser Gln Pro Arg Arg Gly Leu Ser Asp 
    50                  55                  60                  


Ile Ser Pro Ser Xaa Ser Leu Pro Pro Leu Val Glu Gly Gln Leu Arg 
65                  70                  75                  80  


Cys Phe Leu Lys Leu Xaa Val Asn Arg Val Ile Trp Lys Ile Ala Lys 
                85                  90                  95      


Pro Pro Xaa Cys Val Leu Val Arg Val Arg Trp Trp Gly Glu Xaa Ser 
            100                 105                 110         


Asp Gly Xaa Leu Phe Cys Pro Arg Asp Ala Leu Gln Xaa Glu Pro Lys 
        115                 120                 125             


Ala Val Arg Xaa Xaa Xaa Arg Tyr Ala Ile Arg Cys Gly Pro Lys Gln 
    130                 135                 140                 


Phe Xaa Ser Tyr Leu Xaa Asp Met Ala Val Leu Val Leu Glu Val Ile 
145                 150                 155                 160 


Xaa Lys Leu Asp Gly Leu Pro Ile Gly Arg Val Gln Ile Asn Gly Leu 
                165                 170                 175     


Ala Gln Leu Ser Pro Xaa His Gln Ile Asn Gly Phe Phe Xaa Ile 
            180                 185                 190     


<210> 4561
<211> 1000
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(1000)
<223> Selenocysteine

<400> 4561
Met Pro Gly Lys Leu Lys Val Lys Ile Val Ala Gly Arg His Leu Pro 
1               5                   10                  15      


Val Met Asp Arg Ala Ser Asp Leu Xaa Asp Ala Phe Val Glu Val Lys 
            20                  25                  30          


Phe Gly Asn Xaa Xaa Phe Lys Xaa Asp Val Tyr Leu Lys Ser Leu Asn 
        35                  40                  45              


Pro Gln Trp Asn Ser Glu Trp Phe Lys Phe Glu Val Asp Asp Glu Asp 
    50                  55                  60                  


Leu Gln Asp Glu Pro Leu Gln Ile Xaa Val Leu Asp His Asp Xaa Tyr 
65                  70                  75                  80  


Ser Ala Asn Asp Ala Ile Gly Lys Val Tyr Ile Asp Ile Asp Pro Leu 
                85                  90                  95      


Leu Tyr Ser Glu Ala Ala Xaa Val Ile Ser Gly Trp Phe Pro Ile Tyr 
            100                 105                 110         


Asp Xaa Ile His Gly Ile Arg Gly Glu Ile Asn Val Val Val Lys Val 
        115                 120                 125             


Asp Leu Phe Asn Asp Leu Asn Arg Phe Arg Gln Ser Ser Cys Gly Val 
    130                 135                 140                 


Lys Phe Phe Cys Xaa Xaa Ser Ile Pro Lys Cys Tyr Arg Ala Val Ile 
145                 150                 155                 160 


Ile His Gly Phe Val Glu Glu Leu Val Val Asn Glu Asp Pro Glu Tyr 
                165                 170                 175     


Gln Trp Ile Asp Arg Ile Arg Xaa Pro Arg Ala Ser Asn Glu Ala Arg 
            180                 185                 190         


Gln Arg Leu Ile Ser Leu Met Ser Gly Glu Leu Gln Arg Lys Ile Gly 
        195                 200                 205             


Leu Lys Val Leu Glu Met Arg Gly Asn Ala Val Val Gly Tyr Leu Gln 
    210                 215                 220                 


Cys Phe Asp Leu Glu Gly Glu Ser Gly Leu Val Val Arg Ala Ile Gly 
225                 230                 235                 240 


Xaa Ala Cys Xaa Leu Asp Lys Leu Ser Ser Pro Ala Ala Phe Leu Pro 
                245                 250                 255     


Ala Cys Asn Ser Pro Ser Lys Glu Met Lys Glu Ile Pro Phe Asn Glu 
            260                 265                 270         


Asp Pro Asn Pro Asn Xaa His Ser Ser Gly Pro Ser Xaa Pro Leu Lys 
        275                 280                 285             


Asn Gln Xaa Tyr Ser Phe Ser Pro Ser Lys Ser Tyr Ser Arg Gln Ser 
    290                 295                 300                 


Ser Ser Ser Asp Xaa Asp Leu Ser Leu Xaa Pro Lys Xaa Gly Met Gly 
305                 310                 315                 320 


Ser Gly Ser Ala Gly Lys Glu Gly Gly Pro Phe Lys Ala Leu Leu Arg 
                325                 330                 335     


Gln Gln Xaa Gln Ser Ala Leu Glu Gln Arg Glu Phe Pro Phe Phe Xaa 
            340                 345                 350         


Leu Xaa Ala Phe Pro Pro Gly Phe Leu Val His Val Gly Gly Val Val 
        355                 360                 365             


Ser Ala Arg Ser Val Lys Leu Leu Asp Arg Ile His Asn Pro Asp Glu 
    370                 375                 380                 


Pro Glu Xaa Arg Asp Ala Trp Trp Ala Glu Ile Arg Gln Glu Ile Lys 
385                 390                 395                 400 


Ser His Ala Lys Ala Leu Gly Cys His Ala Val Val Gly Tyr Ser Glu 
                405                 410                 415     


Ser Xaa Ser Ile Cys Glu Glu Val Cys Ile Leu Ser Ala Ser Gly Xaa 
            420                 425                 430         


Ala Ala Val Leu Asn Pro Arg Phe Leu Gln Asp Gly Xaa Val Glu Gly 
        435                 440                 445             


Cys Leu Glu Gln Arg Leu Glu Glu Asn Leu Pro Xaa Arg Cys Gly Phe 
    450                 455                 460                 


Cys His Ile Pro Tyr Asp Glu Leu Asn Met Pro Phe Pro Ala His Leu 
465                 470                 475                 480 


Xaa Tyr Cys Tyr Asn Cys Arg Lys Gln Lys Val Pro Asp Val Leu Phe 
                485                 490                 495     


Xaa Xaa Ile Asp Leu Pro Xaa Asp Ala Xaa Val Ile Gly Lys Gly Cys 
            500                 505                 510         


Leu Ile Gln Ala Arg Leu Cys Arg Leu Lys Lys Lys Ala Gln Ala Glu 
        515                 520                 525             


Ala Asn Ala Xaa Ala Ile Ser Asn Leu Leu Pro Phe Met Glu Tyr Glu 
    530                 535                 540                 


Val His Xaa Gln Leu Met Asn Lys Leu Lys Leu Lys Gly Met Asn Ala 
545                 550                 555                 560 


Leu Phe Gly Leu Arg Ile Gln Ile Xaa Val Gly Glu Asn Met Leu Met 
                565                 570                 575     


Gly Leu Ala Ser Ala Xaa Gly Val Tyr Leu Ala Ala Leu Pro Xaa Pro 
            580                 585                 590         


Gly Gly Ile Gln Ile Ala Gly Lys Xaa Pro Asn Asp Gly Ser Tyr Glu 
        595                 600                 605             


Gln His Ile Ser His Met Gln Lys Lys Ile Asn Asp Xaa Ile Ala Lys 
    610                 615                 620                 


Asn Lys Glu Leu Tyr Glu Ile Asn Pro Pro Glu Ile Ser Glu Glu Ile 
625                 630                 635                 640 


Ile Gly Ser Pro Ile Pro Glu Pro Arg Gln Arg Ser Arg Leu Leu Arg 
                645                 650                 655     


Ser Gln Ser Glu Ser Ser Asp Glu Val Xaa Glu Leu Asp Leu Ser His 
            660                 665                 670         


Gly Lys Lys Asp Ala Phe Val Leu Glu Ile Asp Asp Xaa Asp Ala Met 
        675                 680                 685             


Glu Asp Val His Ser Leu Leu Xaa Asp Val Pro Pro Pro Ser Gly Phe 
    690                 695                 700                 


Tyr Ser Cys Asn Xaa Glu Ile Met Pro Gly Ile Asn Asn Trp Xaa Ser 
705                 710                 715                 720 


Glu Ile Gln Met Phe Xaa Ser Val Arg Val Ile Arg Leu Ser Ser Leu 
                725                 730                 735     


Asn Leu Xaa Asn Gln Ala Leu Asn Lys Asn Phe Asn Asp Leu Cys Glu 
            740                 745                 750         


Asn Leu Leu Lys Ser Leu Tyr Phe Lys Leu Arg Ser Met Ile Pro Cys 
        755                 760                 765             


Cys Leu Cys His Val Asn Phe Xaa Val Ser Leu Pro Glu Asp Glu Leu 
    770                 775                 780                 


Ile Gln Val Xaa Val Xaa Ala Val Ala Ile Xaa Phe Asp Lys Asn Gln 
785                 790                 795                 800 


Ala Leu Gln Xaa Xaa Lys Xaa Pro Val Glu Lys Ser Leu Gln Arg Ala 
                805                 810                 815     


Ser Xaa Asp Asn Glu Glu Leu Leu Gln Phe Pro Leu Glu Leu Cys Ser 
            820                 825                 830         


Asp Ser Leu Pro Ser His Pro Phe Pro Pro Ala Lys Ala Met Xaa Val 
        835                 840                 845             


Glu Lys Ala Ser Pro Val Gly Asp Gly Asn Phe Arg Asn Arg Ser Ala 
    850                 855                 860                 


Pro Pro Cys Ala Asn Ser Xaa Val Gly Val Val Lys Met Xaa Pro Leu 
865                 870                 875                 880 


Ser Phe Ile Pro Gly Ala Lys Ile Xaa Lys Tyr Leu Gly Ile Ile Asn 
                885                 890                 895     


Met Phe Phe Ile Arg Glu Xaa Xaa Ser Leu Arg Glu Glu Gly Gly Val 
            900                 905                 910         


Ser Gly Phe Leu His Ala Phe Ile Ala Glu Val Phe Ala Met Val Arg 
        915                 920                 925             


Ala His Val Ala Ala Leu Gly Gly Asn Ala Val Val Ser Tyr Ile Met 
    930                 935                 940                 


Lys Gln Cys Val Phe Met Glu Asn Pro Asn Lys Asn Gln Ala Gln Cys 
945                 950                 955                 960 


Leu Ile Asn Val Ser Gly Asp Ala Val Val Phe Val Arg Glu Ser Asp 
                965                 970                 975     


Leu Glu Val Val Ser Ser Gln Gln Pro Xaa Xaa Asn Cys Gln Ser Ser 
            980                 985                 990         


Cys Xaa Glu Gly Glu Val Xaa Xaa  
        995                 1000 


<210> 4562
<211> 1042
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1042)
<223> Selenocysteine

<400> 4562
Met Pro Gly Lys Leu Lys Val Lys Ile Val Ala Gly Arg His Leu Pro 
1               5                   10                  15      


Val Met Asp Arg Ala Ser Asp Leu Xaa Asp Ala Phe Val Glu Val Lys 
            20                  25                  30          


Phe Gly Asn Xaa Xaa Phe Lys Xaa Asp Val Tyr Leu Lys Ser Leu Asn 
        35                  40                  45              


Pro Gln Trp Asn Ser Glu Trp Phe Lys Phe Glu Val Asp Asp Glu Asp 
    50                  55                  60                  


Leu Gln Asp Glu Pro Leu Gln Ile Xaa Val Leu Asp His Asp Xaa Tyr 
65                  70                  75                  80  


Ser Ala Asn Asp Ala Ile Gly Lys Val Tyr Ile Asp Ile Asp Pro Leu 
                85                  90                  95      


Leu Tyr Ser Glu Ala Ala Xaa Val Ile Ser Gly Trp Phe Pro Ile Tyr 
            100                 105                 110         


Asp Xaa Ile His Gly Ile Arg Gly Glu Ile Asn Val Val Val Lys Val 
        115                 120                 125             


Asp Leu Phe Asn Asp Leu Asn Arg Phe Arg Gln Ser Ser Cys Gly Val 
    130                 135                 140                 


Lys Phe Phe Cys Xaa Xaa Ser Ile Pro Lys Cys Tyr Arg Ala Val Ile 
145                 150                 155                 160 


Ile His Gly Phe Val Glu Glu Leu Val Val Asn Glu Asp Pro Glu Tyr 
                165                 170                 175     


Gln Trp Ile Asp Arg Ile Arg Xaa Pro Arg Ala Ser Asn Glu Ala Arg 
            180                 185                 190         


Gln Arg Leu Ile Ser Leu Met Ser Gly Glu Leu Gln Arg Lys Ile Gly 
        195                 200                 205             


Leu Lys Val Leu Glu Met Arg Gly Asn Ala Val Val Gly Tyr Leu Gln 
    210                 215                 220                 


Cys Phe Asp Leu Glu Gly Glu Ser Gly Leu Val Val Arg Ala Ile Gly 
225                 230                 235                 240 


Xaa Ala Cys Xaa Leu Asp Lys Leu Ser Ser Pro Ala Ala Phe Leu Pro 
                245                 250                 255     


Ala Cys Asn Ser Pro Ser Lys Glu Met Lys Glu Ser Pro Leu Val His 
            260                 265                 270         


Pro Pro Ser His Gly Cys Arg Ser Xaa His Asn Ser Pro Ile His Xaa 
        275                 280                 285             


Ala Xaa Gly Ser Arg Leu Xaa Gln Asn Phe Ser Val Ser Val Pro Xaa 
    290                 295                 300                 


Leu Ile Tyr Xaa Gly Met Gly Ser Gly Ser Ala Gly Lys Glu Gly Gly 
305                 310                 315                 320 


Pro Phe Lys Ala Leu Leu Arg Gln Gln Xaa Gln Ser Ala Leu Glu Gln 
                325                 330                 335     


Arg Glu Phe Pro Phe Phe Xaa Leu Xaa Ala Phe Pro Pro Gly Phe Leu 
            340                 345                 350         


Val His Val Gly Gly Val Val Ser Ala Arg Ser Val Lys Leu Leu Asp 
        355                 360                 365             


Arg Ile His Asn Pro Asp Glu Pro Glu Xaa Arg Asp Ala Trp Trp Ala 
    370                 375                 380                 


Glu Ile Arg Gln Glu Ile Lys Ser His Ala Lys Ala Leu Gly Cys His 
385                 390                 395                 400 


Ala Val Val Gly Tyr Ser Glu Ser Xaa Ser Ile Cys Glu Glu Val Cys 
                405                 410                 415     


Ile Leu Ser Ala Ser Gly Xaa Ala Ala Val Leu Asn Pro Arg Phe Leu 
            420                 425                 430         


Gln Asp Gly Xaa Val Glu Gly Cys Leu Glu Gln Arg Leu Glu Glu Asn 
        435                 440                 445             


Leu Pro Xaa Arg Cys Gly Phe Cys His Ile Pro Tyr Asp Glu Leu Asn 
    450                 455                 460                 


Met Pro Phe Pro Ala His Leu Xaa Tyr Cys Tyr Asn Cys Arg Lys Gln 
465                 470                 475                 480 


Lys Val Pro Asp Val Leu Phe Xaa Xaa Ile Asp Leu Pro Xaa Asp Ala 
                485                 490                 495     


Xaa Val Ile Gly Lys Gly Cys Leu Ile Gln Ala Arg Leu Cys Arg Leu 
            500                 505                 510         


Lys Lys Lys Ala Gln Ala Glu Ala Asn Ala Xaa Ala Ile Ser Asn Leu 
        515                 520                 525             


Leu Pro Phe Met Glu Tyr Glu Val His Xaa Gln Leu Met Asn Lys Leu 
    530                 535                 540                 


Lys Leu Lys Gly Met Asn Ala Leu Phe Gly Leu Arg Ile Gln Ile Xaa 
545                 550                 555                 560 


Val Gly Glu Asn Met Leu Met Gly Leu Ala Ser Ala Xaa Gly Val Tyr 
                565                 570                 575     


Leu Ala Ala Leu Pro Xaa Pro Gly Gly Ile Gln Ile Ala Gly Lys Xaa 
            580                 585                 590         


Pro Asn Asp Gly Ser Tyr Glu Gln His Ile Ser His Met Gln Lys Lys 
        595                 600                 605             


Ile Asn Asp Xaa Ile Ala Lys Asn Lys Glu Leu Tyr Glu Ile Asn Pro 
    610                 615                 620                 


Pro Glu Ile Ser Glu Glu Ile Ile Gly Ser Pro Ile Pro Glu Pro Arg 
625                 630                 635                 640 


Gln Arg Ser Arg Leu Leu Arg Ser Gln Ser Glu Ser Ser Asp Glu Val 
                645                 650                 655     


Xaa Glu Leu Asp Leu Ser His Gly Lys Lys Asp Ala Phe Val Leu Glu 
            660                 665                 670         


Ile Asp Asp Xaa Asp Ala Met Glu Asp Val His Ser Leu Leu Xaa Asp 
        675                 680                 685             


Val Pro Pro Pro Ser Gly Phe Tyr Ser Cys Asn Xaa Glu Ile Met Pro 
    690                 695                 700                 


Gly Ile Asn Asn Trp Xaa Ser Glu Ile Gln Met Phe Xaa Ser Val Arg 
705                 710                 715                 720 


Val Ile Arg Leu Ser Ser Leu Asn Leu Xaa Asn Gln Ala Leu Asn Lys 
                725                 730                 735     


Asn Phe Asn Asp Leu Cys Glu Asn Leu Leu Lys Ser Leu Tyr Phe Lys 
            740                 745                 750         


Leu Arg Ser Met Ile Pro Cys Cys Leu Cys His Val Asn Phe Xaa Val 
        755                 760                 765             


Ser Leu Pro Glu Asp Glu Leu Ile Gln Val Xaa Val Xaa Ala Val Ala 
    770                 775                 780                 


Ile Xaa Phe Asp Lys Asn Gln Ala Leu Gln Xaa Xaa Lys Xaa Pro Val 
785                 790                 795                 800 


Glu Lys Ser Leu Gln Arg Ala Ser Xaa Asp Asn Glu Glu Leu Leu Gln 
                805                 810                 815     


Phe Pro Leu Glu Leu Cys Ser Asp Ser Leu Pro Ser His Pro Phe Pro 
            820                 825                 830         


Pro Ala Lys Glu His Leu Glu Ser Ala Ser Ser Asn Ser Gly Ile Pro 
        835                 840                 845             


Ala Ala Gln Arg Ala Xaa Ser Val Asp Tyr Ser Ser Phe Ala Asp Arg 
    850                 855                 860                 


Cys Ser Ser Trp Ile Glu Leu Ile Lys Leu Lys Ala Gln Xaa Ile Arg 
865                 870                 875                 880 


Arg Gly Ser Ile Lys Xaa Xaa Met Xaa Val Glu Lys Ala Ser Pro Val 
                885                 890                 895     


Gly Asp Gly Asn Phe Arg Asn Arg Ser Ala Pro Pro Cys Ala Asn Ser 
            900                 905                 910         


Xaa Val Gly Val Val Lys Met Xaa Pro Leu Ser Phe Ile Pro Gly Ala 
        915                 920                 925             


Lys Ile Xaa Lys Tyr Leu Gly Ile Ile Asn Met Phe Phe Ile Arg Glu 
    930                 935                 940                 


Xaa Xaa Ser Leu Arg Glu Glu Gly Gly Val Ser Gly Phe Leu His Ala 
945                 950                 955                 960 


Phe Ile Ala Glu Val Phe Ala Met Val Arg Ala His Val Ala Ala Leu 
                965                 970                 975     


Gly Gly Asn Ala Val Val Ser Tyr Ile Met Lys Gln Cys Val Phe Met 
            980                 985                 990         


Glu Asn Pro Asn Lys Asn Gln Ala  Gln Cys Leu Ile Asn  Val Ser Gly 
        995                 1000                 1005             


Asp Ala  Val Val Phe Val Arg  Glu Ser Asp Leu Glu  Val Val Ser 
    1010                 1015                 1020             


Ser Gln  Gln Pro Xaa Xaa Asn  Cys Gln Ser Ser Cys  Xaa Glu Gly 
    1025                 1030                 1035             


Glu Val  Xaa Xaa 
    1040         


<210> 4563
<211> 1051
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1051)
<223> Selenocysteine

<400> 4563
Met Pro Gly Lys Leu Lys Val Lys Ile Val Ala Gly Arg His Leu Pro 
1               5                   10                  15      


Val Met Asp Arg Ala Ser Asp Leu Xaa Asp Ala Phe Val Glu Val Lys 
            20                  25                  30          


Phe Gly Asn Xaa Xaa Phe Lys Xaa Asp Val Tyr Leu Lys Ser Leu Asn 
        35                  40                  45              


Pro Gln Trp Asn Ser Glu Trp Phe Lys Phe Glu Val Asp Asp Glu Asp 
    50                  55                  60                  


Leu Gln Asp Glu Pro Leu Gln Ile Xaa Val Leu Asp His Asp Xaa Tyr 
65                  70                  75                  80  


Ser Ala Asn Asp Ala Ile Gly Lys Val Tyr Ile Asp Ile Asp Pro Leu 
                85                  90                  95      


Leu Tyr Ser Glu Ala Ala Xaa Val Ile Ser Gly Trp Phe Pro Ile Tyr 
            100                 105                 110         


Asp Xaa Ile His Gly Ile Arg Gly Glu Ile Asn Val Val Val Lys Val 
        115                 120                 125             


Asp Leu Phe Asn Asp Leu Asn Arg Phe Arg Gln Ser Ser Cys Gly Val 
    130                 135                 140                 


Lys Phe Phe Cys Xaa Xaa Ser Ile Pro Lys Cys Tyr Arg Ala Val Ile 
145                 150                 155                 160 


Ile His Gly Phe Val Glu Glu Leu Val Val Asn Glu Asp Pro Glu Tyr 
                165                 170                 175     


Gln Trp Ile Asp Arg Ile Arg Xaa Pro Arg Ala Ser Asn Glu Ala Arg 
            180                 185                 190         


Gln Arg Leu Ile Ser Leu Met Ser Gly Glu Leu Gln Arg Lys Ile Gly 
        195                 200                 205             


Leu Lys Val Leu Glu Met Arg Gly Asn Ala Val Val Gly Tyr Leu Gln 
    210                 215                 220                 


Cys Phe Asp Leu Glu Gly Glu Ser Gly Leu Val Val Arg Ala Ile Gly 
225                 230                 235                 240 


Xaa Ala Cys Xaa Leu Asp Lys Leu Ser Ser Pro Ala Ala Phe Leu Pro 
                245                 250                 255     


Ala Cys Asn Ser Pro Ser Lys Glu Met Lys Glu Ile Pro Phe Asn Glu 
            260                 265                 270         


Asp Pro Asn Pro Asn Xaa His Ser Ser Gly Pro Ser Xaa Pro Leu Lys 
        275                 280                 285             


Asn Gln Xaa Tyr Ser Phe Ser Pro Ser Lys Ser Tyr Ser Arg Gln Ser 
    290                 295                 300                 


Ser Ser Ser Asp Xaa Asp Leu Ser Leu Xaa Pro Lys Xaa Gly Met Gly 
305                 310                 315                 320 


Ser Gly Ser Ala Gly Lys Glu Gly Gly Pro Phe Lys Ala Leu Leu Arg 
                325                 330                 335     


Gln Gln Xaa Gln Ser Ala Leu Glu Gln Arg Glu Phe Pro Phe Phe Xaa 
            340                 345                 350         


Leu Xaa Ala Phe Pro Pro Gly Phe Leu Val His Val Gly Gly Val Val 
        355                 360                 365             


Ser Ala Arg Ser Val Lys Leu Leu Asp Arg Ile His Asn Pro Asp Glu 
    370                 375                 380                 


Pro Glu Xaa Arg Asp Ala Trp Trp Ala Glu Ile Arg Gln Glu Ile Lys 
385                 390                 395                 400 


Ser His Ala Lys Ala Leu Gly Cys His Ala Val Val Gly Tyr Ser Glu 
                405                 410                 415     


Ser Xaa Ser Ile Cys Glu Glu Val Cys Ile Leu Ser Ala Ser Gly Xaa 
            420                 425                 430         


Ala Ala Val Leu Asn Pro Arg Phe Leu Gln Asp Gly Xaa Val Glu Gly 
        435                 440                 445             


Cys Leu Glu Gln Arg Leu Glu Glu Asn Leu Pro Xaa Arg Cys Gly Phe 
    450                 455                 460                 


Cys His Ile Pro Tyr Asp Glu Leu Asn Met Pro Phe Pro Ala His Leu 
465                 470                 475                 480 


Xaa Tyr Cys Tyr Asn Cys Arg Lys Gln Lys Val Pro Asp Val Leu Phe 
                485                 490                 495     


Xaa Xaa Ile Asp Leu Pro Xaa Asp Ala Xaa Val Ile Gly Lys Gly Cys 
            500                 505                 510         


Leu Ile Gln Ala Arg Leu Cys Arg Leu Lys Lys Lys Ala Gln Ala Glu 
        515                 520                 525             


Ala Asn Ala Xaa Ala Ile Ser Asn Leu Leu Pro Phe Met Glu Tyr Glu 
    530                 535                 540                 


Val His Xaa Gln Leu Met Asn Lys Leu Lys Leu Lys Gly Met Asn Ala 
545                 550                 555                 560 


Leu Phe Gly Leu Arg Ile Gln Ile Xaa Val Gly Glu Asn Met Leu Met 
                565                 570                 575     


Gly Leu Ala Ser Ala Xaa Gly Val Tyr Leu Ala Ala Leu Pro Xaa Pro 
            580                 585                 590         


Gly Gly Ile Gln Ile Ala Gly Lys Xaa Pro Asn Asp Gly Ser Tyr Glu 
        595                 600                 605             


Gln His Ile Ser His Met Gln Lys Lys Ile Asn Asp Xaa Ile Ala Lys 
    610                 615                 620                 


Asn Lys Glu Leu Tyr Glu Ile Asn Pro Pro Glu Ile Ser Glu Glu Ile 
625                 630                 635                 640 


Ile Gly Ser Pro Ile Pro Glu Pro Arg Gln Arg Ser Arg Leu Leu Arg 
                645                 650                 655     


Ser Gln Ser Glu Ser Ser Asp Glu Val Xaa Glu Leu Asp Leu Ser His 
            660                 665                 670         


Gly Lys Lys Asp Ala Phe Val Leu Glu Ile Asp Asp Xaa Asp Ala Met 
        675                 680                 685             


Glu Asp Val His Ser Leu Leu Xaa Asp Val Pro Pro Pro Ser Gly Phe 
    690                 695                 700                 


Tyr Ser Cys Asn Xaa Glu Ile Met Pro Gly Ile Asn Asn Trp Xaa Ser 
705                 710                 715                 720 


Glu Ile Gln Met Phe Xaa Ser Val Arg Val Ile Arg Leu Ser Ser Leu 
                725                 730                 735     


Asn Leu Xaa Asn Gln Ala Leu Asn Lys Asn Phe Asn Asp Leu Cys Glu 
            740                 745                 750         


Asn Leu Leu Lys Ser Leu Tyr Phe Lys Leu Arg Ser Met Ile Pro Cys 
        755                 760                 765             


Cys Leu Cys His Val Asn Phe Xaa Val Ser Leu Pro Glu Asp Glu Leu 
    770                 775                 780                 


Ile Gln Val Xaa Val Xaa Ala Val Ala Ile Xaa Phe Asp Lys Asn Gln 
785                 790                 795                 800 


Ala Leu Gln Xaa Xaa Lys Xaa Pro Val Glu Lys Ser Leu Gln Arg Ala 
                805                 810                 815     


Ser Xaa Asp Asn Glu Glu Leu Leu Gln Phe Pro Leu Glu Leu Cys Ser 
            820                 825                 830         


Asp Ser Leu Pro Ser His Pro Phe Pro Pro Ala Lys Glu His Leu Glu 
        835                 840                 845             


Ser Ala Ser Ser Asn Ser Gly Ile Pro Ala Ala Gln Arg Ala Xaa Ser 
    850                 855                 860                 


Val Asp Tyr Ser Ser Phe Ala Asp Arg Cys Ser Ser Trp Ile Glu Leu 
865                 870                 875                 880 


Ile Lys Leu Lys Ala Gln Xaa Ile Arg Arg Gly Ser Ile Lys Xaa Xaa 
                885                 890                 895     


Met Xaa Val Glu Lys Ala Ser Pro Val Gly Asp Gly Asn Phe Arg Asn 
            900                 905                 910         


Arg Ser Ala Pro Pro Cys Ala Asn Ser Xaa Val Gly Val Val Lys Met 
        915                 920                 925             


Xaa Pro Leu Ser Phe Ile Pro Gly Ala Lys Ile Xaa Lys Tyr Leu Gly 
    930                 935                 940                 


Ile Ile Asn Met Phe Phe Ile Arg Glu Xaa Xaa Ser Leu Arg Glu Glu 
945                 950                 955                 960 


Gly Gly Val Ser Gly Phe Leu His Ala Phe Ile Ala Glu Val Phe Ala 
                965                 970                 975     


Met Val Arg Ala His Val Ala Ala Leu Gly Gly Asn Ala Val Val Ser 
            980                 985                 990         


Tyr Ile Met Lys Gln Cys Val Phe  Met Glu Asn Pro Asn  Lys Asn Gln 
        995                 1000                 1005             


Ala Gln  Cys Leu Ile Asn Val  Ser Gly Asp Ala Val  Val Phe Val 
    1010                 1015                 1020             


Arg Glu  Ser Asp Leu Glu Val  Val Ser Ser Gln Gln  Pro Xaa Xaa 
    1025                 1030                 1035             


Asn Cys  Gln Ser Ser Cys Xaa  Glu Gly Glu Val Xaa  Xaa 
    1040                 1045                 1050     


<210> 4564
<211> 1053
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1053)
<223> Selenocysteine

<400> 4564
Met Pro Gly Lys Leu Lys Val Lys Ile Val Ala Gly Arg His Leu Pro 
1               5                   10                  15      


Val Met Asp Arg Ala Ser Asp Leu Xaa Asp Ala Phe Val Glu Val Lys 
            20                  25                  30          


Phe Gly Asn Xaa Xaa Phe Lys Xaa Asp Val Tyr Leu Lys Ser Leu Asn 
        35                  40                  45              


Pro Gln Trp Asn Ser Glu Trp Phe Lys Phe Glu Val Asp Asp Glu Asp 
    50                  55                  60                  


Leu Gln Asp Glu Pro Leu Gln Ile Xaa Val Leu Asp His Asp Xaa Tyr 
65                  70                  75                  80  


Ser Ala Asn Asp Ala Ile Gly Lys Val Tyr Ile Asp Ile Asp Pro Leu 
                85                  90                  95      


Leu Tyr Ser Glu Ala Ala Xaa Val Ile Ser Gly Trp Phe Pro Ile Tyr 
            100                 105                 110         


Asp Xaa Ile His Gly Ile Arg Gly Glu Ile Asn Val Val Val Lys Val 
        115                 120                 125             


Asp Leu Phe Asn Asp Leu Asn Arg Phe Arg Gln Ser Ser Cys Gly Val 
    130                 135                 140                 


Lys Phe Phe Cys Xaa Xaa Ser Ile Pro Lys Cys Tyr Arg Ala Val Ile 
145                 150                 155                 160 


Ile His Gly Phe Val Glu Glu Leu Val Val Asn Glu Asp Pro Glu Tyr 
                165                 170                 175     


Gln Trp Ile Asp Arg Ile Arg Xaa Pro Arg Ala Ser Asn Glu Ala Arg 
            180                 185                 190         


Gln Arg Leu Ile Ser Leu Met Ser Gly Glu Leu Gln Arg Lys Ile Gly 
        195                 200                 205             


Leu Lys Val Leu Glu Met Arg Gly Asn Ala Val Val Gly Tyr Leu Gln 
    210                 215                 220                 


Cys Phe Asp Leu Glu Gly Glu Ser Gly Leu Val Val Arg Ala Ile Gly 
225                 230                 235                 240 


Xaa Ala Cys Xaa Leu Asp Lys Leu Ser Ser Pro Ala Ala Phe Leu Pro 
                245                 250                 255     


Ala Cys Asn Ser Pro Ser Lys Glu Met Lys Glu Ser Pro Leu Val His 
            260                 265                 270         


Pro Pro Ser His Gly Cys Arg Ser Xaa His Asn Ser Pro Ile His Xaa 
        275                 280                 285             


Ala Xaa Gly Ser Arg Leu Xaa Gln Asn Phe Ser Val Ser Val Pro Xaa 
    290                 295                 300                 


Leu Ile Tyr Xaa Gly Met Gly Ser Gly Ser Ala Gly Lys Glu Gly Gly 
305                 310                 315                 320 


Pro Phe Lys Ala Leu Leu Arg Gln Gln Xaa Gln Ser Ala Leu Glu Gln 
                325                 330                 335     


Arg Gly Gly Ser Pro His Arg Phe Cys Arg Arg Arg Glu Phe Pro Phe 
            340                 345                 350         


Phe Xaa Leu Xaa Ala Phe Pro Pro Gly Phe Leu Val His Val Gly Gly 
        355                 360                 365             


Val Val Ser Ala Arg Ser Val Lys Leu Leu Asp Arg Ile His Asn Pro 
    370                 375                 380                 


Asp Glu Pro Glu Xaa Arg Asp Ala Trp Trp Ala Glu Ile Arg Gln Glu 
385                 390                 395                 400 


Ile Lys Ser His Ala Lys Ala Leu Gly Cys His Ala Val Val Gly Tyr 
                405                 410                 415     


Ser Glu Ser Xaa Ser Ile Cys Glu Glu Val Cys Ile Leu Ser Ala Ser 
            420                 425                 430         


Gly Xaa Ala Ala Val Leu Asn Pro Arg Phe Leu Gln Asp Gly Xaa Val 
        435                 440                 445             


Glu Gly Cys Leu Glu Gln Arg Leu Glu Glu Asn Leu Pro Xaa Arg Cys 
    450                 455                 460                 


Gly Phe Cys His Ile Pro Tyr Asp Glu Leu Asn Met Pro Phe Pro Ala 
465                 470                 475                 480 


His Leu Xaa Tyr Cys Tyr Asn Cys Arg Lys Gln Lys Val Pro Asp Val 
                485                 490                 495     


Leu Phe Xaa Xaa Ile Asp Leu Pro Xaa Asp Ala Xaa Val Ile Gly Lys 
            500                 505                 510         


Gly Cys Leu Ile Gln Ala Arg Leu Cys Arg Leu Lys Lys Lys Ala Gln 
        515                 520                 525             


Ala Glu Ala Asn Ala Xaa Ala Ile Ser Asn Leu Leu Pro Phe Met Glu 
    530                 535                 540                 


Tyr Glu Val His Xaa Gln Leu Met Asn Lys Leu Lys Leu Lys Gly Met 
545                 550                 555                 560 


Asn Ala Leu Phe Gly Leu Arg Ile Gln Ile Xaa Val Gly Glu Asn Met 
                565                 570                 575     


Leu Met Gly Leu Ala Ser Ala Xaa Gly Val Tyr Leu Ala Ala Leu Pro 
            580                 585                 590         


Xaa Pro Gly Gly Ile Gln Ile Ala Gly Lys Xaa Pro Asn Asp Gly Ser 
        595                 600                 605             


Tyr Glu Gln His Ile Ser His Met Gln Lys Lys Ile Asn Asp Xaa Ile 
    610                 615                 620                 


Ala Lys Asn Lys Glu Leu Tyr Glu Ile Asn Pro Pro Glu Ile Ser Glu 
625                 630                 635                 640 


Glu Ile Ile Gly Ser Pro Ile Pro Glu Pro Arg Gln Arg Ser Arg Leu 
                645                 650                 655     


Leu Arg Ser Gln Ser Glu Ser Ser Asp Glu Val Xaa Glu Leu Asp Leu 
            660                 665                 670         


Ser His Gly Lys Lys Asp Ala Phe Val Leu Glu Ile Asp Asp Xaa Asp 
        675                 680                 685             


Ala Met Glu Asp Val His Ser Leu Leu Xaa Asp Val Pro Pro Pro Ser 
    690                 695                 700                 


Gly Phe Tyr Ser Cys Asn Xaa Glu Ile Met Pro Gly Ile Asn Asn Trp 
705                 710                 715                 720 


Xaa Ser Glu Ile Gln Met Phe Xaa Ser Val Arg Val Ile Arg Leu Ser 
                725                 730                 735     


Ser Leu Asn Leu Xaa Asn Gln Ala Leu Asn Lys Asn Phe Asn Asp Leu 
            740                 745                 750         


Cys Glu Asn Leu Leu Lys Ser Leu Tyr Phe Lys Leu Arg Ser Met Ile 
        755                 760                 765             


Pro Cys Cys Leu Cys His Val Asn Phe Xaa Val Ser Leu Pro Glu Asp 
    770                 775                 780                 


Glu Leu Ile Gln Val Xaa Val Xaa Ala Val Ala Ile Xaa Phe Asp Lys 
785                 790                 795                 800 


Asn Gln Ala Leu Gln Xaa Xaa Lys Xaa Pro Val Glu Lys Ser Leu Gln 
                805                 810                 815     


Arg Ala Ser Xaa Asp Asn Glu Glu Leu Leu Gln Phe Pro Leu Glu Leu 
            820                 825                 830         


Cys Ser Asp Ser Leu Pro Ser His Pro Phe Pro Pro Ala Lys Glu His 
        835                 840                 845             


Leu Glu Ser Ala Ser Ser Asn Ser Gly Ile Pro Ala Ala Gln Arg Ala 
    850                 855                 860                 


Xaa Ser Val Asp Tyr Ser Ser Phe Ala Asp Arg Cys Ser Ser Trp Ile 
865                 870                 875                 880 


Glu Leu Ile Lys Leu Lys Ala Gln Xaa Ile Arg Arg Gly Ser Ile Lys 
                885                 890                 895     


Xaa Xaa Met Xaa Val Glu Lys Ala Ser Pro Val Gly Asp Gly Asn Phe 
            900                 905                 910         


Arg Asn Arg Ser Ala Pro Pro Cys Ala Asn Ser Xaa Val Gly Val Val 
        915                 920                 925             


Lys Met Xaa Pro Leu Ser Phe Ile Pro Gly Ala Lys Ile Xaa Lys Tyr 
    930                 935                 940                 


Leu Gly Ile Ile Asn Met Phe Phe Ile Arg Glu Xaa Xaa Ser Leu Arg 
945                 950                 955                 960 


Glu Glu Gly Gly Val Ser Gly Phe Leu His Ala Phe Ile Ala Glu Val 
                965                 970                 975     


Phe Ala Met Val Arg Ala His Val Ala Ala Leu Gly Gly Asn Ala Val 
            980                 985                 990         


Val Ser Tyr Ile Met Lys Gln Cys  Val Phe Met Glu Asn  Pro Asn Lys 
        995                 1000                 1005             


Asn Gln  Ala Gln Cys Leu Ile  Asn Val Ser Gly Asp  Ala Val Val 
    1010                 1015                 1020             


Phe Val  Arg Glu Ser Asp Leu  Glu Val Val Ser Ser  Gln Gln Pro 
    1025                 1030                 1035             


Xaa Xaa  Asn Cys Gln Ser Ser  Cys Xaa Glu Gly Glu  Val Xaa Xaa 
    1040                 1045                 1050             


<210> 4565
<211> 1054
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1054)
<223> Selenocysteine

<400> 4565
Met Pro Gly Lys Leu Lys Val Lys Ile Val Ala Gly Arg His Leu Pro 
1               5                   10                  15      


Val Met Asp Arg Ala Ser Asp Leu Xaa Asp Ala Phe Val Glu Val Lys 
            20                  25                  30          


Phe Gly Asn Xaa Xaa Phe Lys Xaa Asp Val Tyr Leu Lys Ser Leu Asn 
        35                  40                  45              


Pro Gln Trp Asn Ser Glu Trp Phe Lys Phe Glu Val Asp Asp Glu Asp 
    50                  55                  60                  


Leu Gln Asp Glu Pro Leu Gln Ile Xaa Val Leu Asp His Asp Xaa Tyr 
65                  70                  75                  80  


Ser Ala Asn Asp Ala Ile Gly Lys Val Tyr Ile Asp Ile Asp Pro Leu 
                85                  90                  95      


Leu Tyr Ser Glu Ala Ala Xaa Val Ile Ser Gly Trp Phe Pro Ile Tyr 
            100                 105                 110         


Asp Xaa Ile His Gly Ile Arg Gly Glu Ile Asn Val Val Val Lys Val 
        115                 120                 125             


Asp Leu Phe Asn Asp Leu Asn Arg Phe Arg Gln Ser Ser Cys Gly Val 
    130                 135                 140                 


Lys Phe Phe Cys Xaa Xaa Ser Ile Pro Lys Cys Tyr Arg Ala Val Ile 
145                 150                 155                 160 


Ile His Gly Phe Val Glu Glu Leu Val Val Asn Glu Asp Pro Glu Tyr 
                165                 170                 175     


Gln Trp Ile Asp Arg Ile Arg Xaa Pro Arg Ala Ser Asn Glu Ala Arg 
            180                 185                 190         


Gln Arg Leu Ile Ser Leu Met Ser Gly Glu Leu Gln Arg Lys Ile Gly 
        195                 200                 205             


Leu Lys Val Leu Glu Met Arg Gly Asn Ala Val Val Gly Tyr Leu Gln 
    210                 215                 220                 


Cys Phe Asp Leu Glu Gly Glu Ser Gly Leu Val Val Arg Ala Ile Gly 
225                 230                 235                 240 


Xaa Ala Cys Xaa Leu Asp Lys Leu Ser Ser Pro Ala Ala Phe Leu Pro 
                245                 250                 255     


Ala Cys Asn Ser Pro Ser Lys Glu Met Lys Glu Ser Pro Leu Val His 
            260                 265                 270         


Pro Pro Ser His Gly Cys Arg Ser Xaa His Asn Ser Pro Ile His Xaa 
        275                 280                 285             


Ala Xaa Gly Ser Arg Leu Xaa Gln Asn Phe Ser Val Ser Val Pro Xaa 
    290                 295                 300                 


Leu Ile Tyr Xaa Gly Met Gly Ser Gly Ser Ala Gly Lys Glu Gly Gly 
305                 310                 315                 320 


Pro Phe Lys Ala Leu Leu Arg Gln Gln Xaa Gln Ser Ala Leu Glu Gln 
                325                 330                 335     


Arg Glu Phe Pro Phe Phe Xaa Leu Xaa Ala Phe Pro Pro Gly Phe Leu 
            340                 345                 350         


Val His Val Gly Gly Val Val Ser Ala Arg Ser Val Lys Leu Leu Asp 
        355                 360                 365             


Arg Ile His Asn Pro Ala Phe Val Gly Ile Met Gly Asn Xaa Arg Ser 
    370                 375                 380                 


Tyr Lys Leu Leu Asp Trp Asn Ser Phe Asn Ser Asp Glu Pro Glu Xaa 
385                 390                 395                 400 


Arg Asp Ala Trp Trp Ala Glu Ile Arg Gln Glu Ile Lys Ser His Ala 
                405                 410                 415     


Lys Ala Leu Gly Cys His Ala Val Val Gly Tyr Ser Glu Ser Xaa Ser 
            420                 425                 430         


Ile Cys Glu Glu Val Cys Ile Leu Ser Ala Ser Gly Xaa Ala Ala Val 
        435                 440                 445             


Leu Asn Pro Arg Phe Leu Gln Asp Gly Xaa Val Glu Gly Cys Leu Glu 
    450                 455                 460                 


Gln Arg Leu Glu Glu Asn Leu Pro Xaa Arg Cys Gly Phe Cys His Ile 
465                 470                 475                 480 


Pro Tyr Asp Glu Leu Asn Met Pro Phe Pro Ala His Leu Xaa Tyr Cys 
                485                 490                 495     


Tyr Asn Cys Arg Lys Gln Lys Val Pro Asp Val Leu Phe Xaa Xaa Ile 
            500                 505                 510         


Asp Leu Pro Xaa Asp Ala Xaa Val Ile Gly Lys Gly Cys Leu Ile Gln 
        515                 520                 525             


Ala Arg Leu Cys Arg Leu Lys Lys Lys Ala Gln Ala Glu Ala Asn Ala 
    530                 535                 540                 


Xaa Ala Ile Ser Asn Leu Leu Pro Phe Met Glu Tyr Glu Val His Xaa 
545                 550                 555                 560 


Gln Leu Met Asn Lys Leu Lys Leu Lys Gly Met Asn Ala Leu Phe Gly 
                565                 570                 575     


Leu Arg Ile Gln Ile Xaa Val Gly Glu Asn Met Leu Met Gly Leu Ala 
            580                 585                 590         


Ser Ala Xaa Gly Val Tyr Leu Ala Ala Leu Pro Xaa Pro Gly Gly Ile 
        595                 600                 605             


Gln Ile Ala Gly Lys Xaa Pro Asn Asp Gly Ser Tyr Glu Gln His Ile 
    610                 615                 620                 


Ser His Met Gln Lys Lys Ile Asn Asp Xaa Ile Ala Lys Asn Lys Glu 
625                 630                 635                 640 


Leu Tyr Glu Ile Asn Pro Pro Glu Ile Ser Glu Glu Ile Ile Gly Ser 
                645                 650                 655     


Pro Ile Pro Glu Pro Arg Gln Arg Ser Arg Leu Leu Arg Ser Gln Ser 
            660                 665                 670         


Glu Ser Ser Asp Glu Val Xaa Glu Leu Asp Leu Ser His Gly Lys Lys 
        675                 680                 685             


Asp Ala Phe Val Leu Glu Ile Asp Asp Xaa Asp Ala Met Glu Asp Val 
    690                 695                 700                 


His Ser Leu Leu Xaa Asp Val Pro Pro Pro Ser Gly Phe Tyr Ser Cys 
705                 710                 715                 720 


Asn Xaa Glu Ile Met Pro Gly Ile Asn Asn Trp Xaa Ser Glu Ile Gln 
                725                 730                 735     


Met Phe Xaa Ser Val Arg Val Ile Arg Leu Ser Ser Leu Asn Leu Xaa 
            740                 745                 750         


Asn Gln Ala Leu Asn Lys Asn Phe Asn Asp Leu Cys Glu Asn Leu Leu 
        755                 760                 765             


Lys Ser Leu Tyr Phe Lys Leu Arg Ser Met Ile Pro Cys Cys Leu Cys 
    770                 775                 780                 


His Val Asn Phe Xaa Val Ser Leu Pro Glu Asp Glu Leu Ile Gln Val 
785                 790                 795                 800 


Xaa Val Xaa Ala Val Ala Ile Xaa Phe Asp Lys Asn Gln Ala Leu Gln 
                805                 810                 815     


Xaa Xaa Lys Xaa Pro Val Glu Lys Ser Leu Gln Arg Ala Ser Xaa Asp 
            820                 825                 830         


Asn Glu Glu Leu Leu Gln Phe Pro Leu Glu Leu Cys Ser Asp Ser Leu 
        835                 840                 845             


Pro Ser His Pro Phe Pro Pro Ala Lys Glu His Leu Glu Ser Ala Ser 
    850                 855                 860                 


Ser Asn Ser Gly Ile Pro Ala Ala Gln Arg Asp Arg Cys Ser Ser Trp 
865                 870                 875                 880 


Ile Glu Leu Ile Lys Leu Lys Ala Gln Xaa Ile Arg Arg Gly Ser Ile 
                885                 890                 895     


Lys Xaa Xaa Met Xaa Val Glu Lys Ala Ser Pro Val Gly Asp Gly Asn 
            900                 905                 910         


Phe Arg Asn Arg Ser Ala Pro Pro Cys Ala Asn Ser Xaa Val Gly Val 
        915                 920                 925             


Val Lys Met Xaa Pro Leu Ser Phe Ile Pro Gly Ala Lys Ile Xaa Lys 
    930                 935                 940                 


Tyr Leu Gly Ile Ile Asn Met Phe Phe Ile Arg Glu Xaa Xaa Ser Leu 
945                 950                 955                 960 


Arg Glu Glu Gly Gly Val Ser Gly Phe Leu His Ala Phe Ile Ala Glu 
                965                 970                 975     


Val Phe Ala Met Val Arg Ala His Val Ala Ala Leu Gly Gly Asn Ala 
            980                 985                 990         


Val Val Ser Tyr Ile Met Lys Gln  Cys Val Phe Met Glu  Asn Pro Asn 
        995                 1000                 1005             


Lys Asn  Gln Ala Gln Cys Leu  Ile Asn Val Ser Gly  Asp Ala Val 
    1010                 1015                 1020             


Val Phe  Val Arg Glu Ser Asp  Leu Glu Val Val Ser  Ser Gln Gln 
    1025                 1030                 1035             


Pro Xaa  Xaa Asn Cys Gln Ser  Ser Cys Xaa Glu Gly  Glu Val Xaa 
    1040                 1045                 1050             


Xaa 
    


<210> 4566
<211> 165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<400> 4566
Xaa Met Ser Gly Glu Leu Gln Arg Lys Ile Gly Leu Lys Val Leu Glu 
1               5                   10                  15      


Met Arg Gly Asn Ala Val Val Gly Tyr Leu Gln Cys Phe Asp Leu Glu 
            20                  25                  30          


Gly Glu Ser Gly Leu Val Val Arg Ala Ile Gly Xaa Ala Cys Xaa Leu 
        35                  40                  45              


Asp Lys Leu Ser Ser Pro Ala Ala Phe Leu Pro Ala Cys Asn Ser Pro 
    50                  55                  60                  


Ser Lys Glu Met Lys Glu Ile Pro Phe Asn Glu Asp Pro Asn Pro Asn 
65                  70                  75                  80  


Xaa His Ser Ser Gly Pro Ser Xaa Pro Leu Lys Asn Gln Xaa Tyr Ser 
                85                  90                  95      


Phe Ser Pro Ser Lys Ser Tyr Ser Arg Gln Ser Ser Ser Ser Asp Xaa 
            100                 105                 110         


Asp Leu Ser Leu Xaa Pro Lys Xaa Gly Met Gly Ser Gly Ser Ala Gly 
        115                 120                 125             


Lys Glu Gly Gly Pro Phe Lys Ala Leu Leu Arg Gln Gln Xaa Gln Ser 
    130                 135                 140                 


Ala Leu Glu Gln Arg Met Asn Gln Lys Leu Glu Met His Gly Gly Gln 
145                 150                 155                 160 


Lys Ser Asp Lys Lys 
                165 


<210> 4567
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<400> 4567
Xaa Gln Gln Xaa Gln Ser Ala Leu Glu Gln Arg Gly Gly Ser Pro His 
1               5                   10                  15      


Arg Phe Cys Arg Arg Arg Glu Phe Pro Phe Phe Xaa Leu Xaa Ala Phe 
            20                  25                  30          


Pro Pro Gly Phe Leu Val His Val Gly Gly Val Val Ser Ala Arg Ser 
        35                  40                  45              


Val Lys Leu Leu Asp Arg Ile His Asn Pro Ala Phe Val Gly Ile Met 
    50                  55                  60                  


Gly Asn Xaa Arg Ser Tyr Lys Leu Leu Asp Trp Asn Ser Phe Asn Ser 
65                  70                  75                  80  


Asp Glu Pro Glu Xaa Arg Asp Ala Trp Trp Ala Glu Ile Arg Gln Glu 
                85                  90                  95      


Ile Lys Ser His Ala Lys Ala Leu Gly Cys His Ala Val Val Gly Tyr 
            100                 105                 110         


Ser Glu Ser Xaa Ser Ile Cys Glu Glu Val Cys Ile Leu Ser Ala Ser 
        115                 120                 125             


Gly Xaa Ala Ala Val Leu Asn Pro Arg Phe Leu Gln Asp Gly Xaa Val 
    130                 135                 140                 


Glu Gly Cys Leu Glu Gln Arg Leu Glu Glu Asn Leu Pro Xaa Arg Cys 
145                 150                 155                 160 


Gly Phe Cys His Ile Pro Tyr Asp Glu Leu Asn Met Pro Phe Pro Ala 
                165                 170                 175     


His Leu Xaa Tyr Cys Tyr 
            180         


<210> 4568
<211> 283
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(205)
<223> Selenocysteine

<400> 4568
Xaa Trp Xaa Ser Glu Ile Gln Met Phe Xaa Ser Val Arg Val Ile Arg 
1               5                   10                  15      


Leu Ser Ser Leu Asn Leu Xaa Asn Gln Ala Leu Asn Lys Asn Phe Asn 
            20                  25                  30          


Asp Leu Cys Glu Asn Leu Leu Lys Ser Leu Tyr Phe Lys Leu Arg Ser 
        35                  40                  45              


Met Ile Pro Cys Cys Leu Cys His Val Asn Phe Xaa Val Ser Leu Pro 
    50                  55                  60                  


Glu Asp Glu Leu Ile Gln Val Xaa Val Xaa Ala Val Ala Ile Xaa Phe 
65                  70                  75                  80  


Asp Lys Asn Gln Ala Leu Gln Xaa Xaa Lys Xaa Pro Val Glu Lys Ser 
                85                  90                  95      


Leu Gln Arg Ala Ser Xaa Asp Asn Glu Glu Leu Leu Gln Phe Pro Leu 
            100                 105                 110         


Glu Leu Cys Ser Asp Ser Leu Pro Ser His Pro Phe Pro Pro Ala Lys 
        115                 120                 125             


Glu His Leu Glu Ser Ala Ser Ser Asn Ser Gly Ile Pro Ala Ala Gln 
    130                 135                 140                 


Arg Ala Met Xaa Val Glu Lys Ala Ser Pro Val Gly Asp Gly Asn Phe 
145                 150                 155                 160 


Arg Asn Arg Ser Ala Pro Pro Cys Ala Asn Ser Xaa Val Gly Val Val 
                165                 170                 175     


Lys Met Xaa Pro Leu Ser Phe Ile Pro Gly Ala Lys Ile Xaa Lys Tyr 
            180                 185                 190         


Leu Gly Ile Ile Asn Met Phe Phe Ile Arg Glu Xaa Xaa Ser Leu Arg 
        195                 200                 205             


Glu Glu Gly Gly Val Ser Gly Phe Leu His Ala Phe Ile Ala Glu Val 
    210                 215                 220                 


Phe Ala Met Val Arg Ala His Val Ala Ala Leu Gly Gly Asn Ala Val 
225                 230                 235                 240 


Val Ser Tyr Ile Met Lys Gln Cys Val Phe Met Glu Asn Pro Asn Lys 
                245                 250                 255     


Asn Gln Ala Gln Cys Leu Ile Asn Val Ser Gly Asp Ala Val Val Phe 
            260                 265                 270         


Val Arg Glu Ser Asp Leu Glu Val Val Ser Ser 
        275                 280             


<210> 4569
<211> 148
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<400> 4569
Met Ala Ala Ser Pro Ala Arg Pro Ala Val Leu Ala Leu Xaa Gly Leu 
1               5                   10                  15      


Ala Leu Leu Leu Leu Leu Cys Trp Gly Pro Gly Gly Ile Ser Gly Asn 
            20                  25                  30          


Lys Leu Lys Leu Met Leu Gln Lys Arg Glu Ala Pro Val Pro Xaa Lys 
        35                  40                  45              


Xaa Lys Val Ala Val Asp Glu Asn Lys Ala Lys Glu Phe Leu Gly Ser 
    50                  55                  60                  


Leu Lys Arg Gln Lys Arg Gln Leu Trp Asp Arg Xaa Arg Pro Glu Val 
65                  70                  75                  80  


Gln Gln Trp Tyr Gln Gln Phe Leu Tyr Met Gly Phe Asp Glu Ala Lys 
                85                  90                  95      


Phe Glu Asp Asp Ile Xaa Tyr Trp Leu Asn Arg Asp Arg Asn Gly His 
            100                 105                 110         


Glu Tyr Tyr Gly Asp Tyr Tyr Gln Arg His Tyr Asp Glu Asp Ser Ala 
        115                 120                 125             


Ile Gly Pro Arg Ser Pro Tyr Gly Phe Arg His Gly Ala Ser Val Asn 
    130                 135                 140                 


Tyr Asp Asp Tyr 
145             


<210> 4570
<211> 112
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 4570
Met Leu Gln Lys Arg Glu Ala Pro Val Pro Xaa Lys Xaa Lys Val Ala 
1               5                   10                  15      


Val Asp Glu Asn Lys Ala Lys Glu Phe Leu Gly Ser Leu Lys Arg Gln 
            20                  25                  30          


Lys Arg Gln Leu Trp Asp Arg Xaa Arg Pro Glu Val Gln Gln Trp Tyr 
        35                  40                  45              


Gln Gln Phe Leu Tyr Met Gly Phe Asp Glu Ala Lys Phe Glu Asp Asp 
    50                  55                  60                  


Ile Xaa Tyr Trp Leu Asn Arg Asp Arg Asn Gly His Glu Tyr Tyr Gly 
65                  70                  75                  80  


Asp Tyr Tyr Gln Arg His Tyr Asp Glu Asp Ser Ala Ile Gly Pro Arg 
                85                  90                  95      


Ser Pro Tyr Gly Phe Arg His Gly Ala Ser Val Asn Tyr Asp Asp Tyr 
            100                 105                 110         


<210> 4571
<211> 142
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<400> 4571
Met Gln Gln Leu Arg Val Arg Gly Ser Tyr Arg Ser Ala Ser Gln Phe 
1               5                   10                  15      


Ala Gly Trp Arg Arg Val Phe Tyr Gln Ala Arg Gln Gly Gly Ile Ser 
            20                  25                  30          


Gly Asn Lys Leu Lys Leu Met Leu Gln Lys Arg Glu Ala Pro Val Pro 
        35                  40                  45              


Xaa Lys Xaa Lys Val Ala Val Asp Glu Asn Lys Ala Lys Glu Phe Leu 
    50                  55                  60                  


Gly Ser Leu Lys Arg Gln Lys Arg Gln Leu Trp Asp Arg Xaa Arg Pro 
65                  70                  75                  80  


Glu Val Gln Gln Trp Tyr Gln Gln Phe Leu Tyr Met Gly Phe Asp Glu 
                85                  90                  95      


Ala Lys Phe Glu Asp Asp Ile Xaa Tyr Trp Leu Asn Arg Asp Arg Asn 
            100                 105                 110         


Gly His Glu Tyr Tyr Gly Asp Tyr Tyr Gln Arg His Tyr Asp Glu Asp 
        115                 120                 125             


Ser Ala Ile Gly Pro Arg Ser Pro Tyr Gly Phe Arg His Gly 
    130                 135                 140         


<210> 4572
<211> 192
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 4572
Ile Xaa His Arg Ile His Trp Glu Ser Ala Ser Leu Leu Arg Ser Glu 
1               5                   10                  15      


Glu Xaa Lys Glu Asn Glu Gly Phe Xaa Val Xaa Ala Glu Gly Lys Gly 
            20                  25                  30          


Gln Gly Xaa Leu Ser Val Val Xaa Met Tyr His Ala Lys Ala Lys Asp 
        35                  40                  45              


Gln Leu Xaa Cys Asn Lys Phe Asp Leu Lys Val Xaa Ile Lys Pro Ala 
    50                  55                  60                  


Pro Glu Xaa Gly Ile Pro Ser Pro Ile Phe Leu Ser Ser Val Phe Leu 
65                  70                  75                  80  


Glu Lys Arg Pro Gln Asp Ala Lys Asn Xaa Met Ile Leu Glu Ile Cys 
                85                  90                  95      


Xaa Arg Tyr Arg Gly Asp Gln Asp Ala Xaa Met Ser Ile Leu Asp Ile 
            100                 105                 110         


Ser Met Met Xaa Gly Phe Ala Pro Asp Xaa Asp Asp Leu Lys Gln Leu 
        115                 120                 125             


Ala Asn Gly Val Asp Arg Tyr Ile Ser Lys Tyr Glu Leu Asp Lys Ala 
    130                 135                 140                 


Phe Ser Asp Arg Asn Xaa Leu Ile Ile Tyr Leu Asp Lys Val Ser His 
145                 150                 155                 160 


Ser Glu Asp Asp Cys Leu Ala Phe Lys Val His Gln Tyr Phe Asn Val 
                165                 170                 175     


Glu Leu Ile Gln Pro Gly Ala Val Lys Val Tyr Ala Tyr Tyr Asn Leu 
            180                 185                 190         


<210> 4573
<211> 1663
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1272)..(1272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1308)..(1308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1324)..(1324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1346)..(1346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1357)..(1357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1366)..(1366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1383)..(1383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1399)..(1399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1409)..(1409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1415)..(1415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1443)..(1443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1490)..(1490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1528)..(1528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1583)..(1583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1626)..(1626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1653)..(1653)
<223> Selenocysteine

<400> 4573
Met Gly Pro Xaa Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Xaa His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly Ser Pro Met Tyr Ser Ile Ile Xaa Pro Asn 
            20                  25                  30          


Ile Leu Arg Leu Glu Ser Glu Glu Xaa Met Val Leu Glu Ala His Asp 
        35                  40                  45              


Ala Gln Gly Asp Val Pro Val Xaa Val Xaa Val His Asp Phe Pro Gly 
    50                  55                  60                  


Lys Lys Leu Val Leu Ser Ser Glu Lys Xaa Val Leu Xaa Pro Ala Xaa 
65                  70                  75                  80  


Asn His Met Gly Asn Val Xaa Phe Xaa Ile Pro Ala Asn Arg Glu Phe 
                85                  90                  95      


Lys Ser Glu Lys Gly Arg Asn Lys Phe Val Xaa Val Gln Ala Xaa Phe 
            100                 105                 110         


Gly Xaa Gln Val Val Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly 
        115                 120                 125             


Tyr Leu Phe Ile Gln Xaa Asp Lys Xaa Ile Tyr Xaa Pro Gly Ser Xaa 
    130                 135                 140                 


Val Leu Tyr Arg Ile Phe Xaa Val Asn His Lys Leu Leu Pro Val Gly 
145                 150                 155                 160 


Arg Xaa Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys 
                165                 170                 175     


Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser 
            180                 185                 190         


Trp Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala 
        195                 200                 205             


Tyr Tyr Glu Asn Ser Pro Gln Gln Val Phe Ser Xaa Glu Phe Glu Val 
    210                 215                 220                 


Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Ile Val Glu Pro Xaa Glu 
225                 230                 235                 240 


Lys Phe Tyr Tyr Ile Tyr Asn Glu Lys Gly Leu Glu Val Xaa Ile Xaa 
                245                 250                 255     


Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu Gly Xaa Ala Phe Val Ile 
            260                 265                 270         


Phe Gly Ile Gln Asp Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu 
        275                 280                 285             


Lys Arg Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg 
    290                 295                 300                 


Lys Val Leu Leu Asp Gly Val Gln Asn Pro Arg Ala Glu Asp Leu Val 
305                 310                 315                 320 


Gly Lys Ser Leu Tyr Val Ser Ala Xaa Val Ile Leu His Ser Gly Ser 
                325                 330                 335     


Asp Met Val Gln Ala Glu Arg Ser Gly Ile Pro Ile Val Xaa Ser Pro 
            340                 345                 350         


Tyr Gln Ile His Phe Xaa Lys Xaa Pro Lys Tyr Phe Lys Pro Gly Met 
        355                 360                 365             


Pro Phe Asp Leu Met Val Phe Val Xaa Asn Pro Asp Gly Ser Pro Ala 
    370                 375                 380                 


Tyr Arg Val Pro Val Ala Val Gln Gly Glu Asp Xaa Val Gln Ser Leu 
385                 390                 395                 400 


Xaa Gln Gly Asp Gly Val Ala Lys Leu Ser Ile Asn Xaa His Pro Ser 
                405                 410                 415     


Gln Lys Pro Leu Ser Ile Xaa Val Arg Xaa Lys Lys Gln Glu Leu Ser 
            420                 425                 430         


Glu Ala Glu Gln Ala Xaa Arg Xaa Met Gln Ala Leu Pro Tyr Ser Xaa 
        435                 440                 445             


Val Gly Asn Ser Asn Asn Tyr Leu His Leu Ser Val Leu Arg Xaa Glu 
    450                 455                 460                 


Leu Arg Pro Gly Glu Xaa Leu Asn Val Asn Phe Leu Leu Arg Met Asp 
465                 470                 475                 480 


Arg Ala His Glu Ala Lys Ile Arg Tyr Tyr Xaa Tyr Leu Ile Met Asn 
                485                 490                 495     


Lys Gly Arg Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 
            500                 505                 510         


Asp Leu Val Val Leu Pro Leu Ser Ile Xaa Xaa Asp Phe Ile Pro Ser 
        515                 520                 525             


Phe Arg Leu Val Ala Tyr Tyr Xaa Leu Ile Gly Ala Ser Gly Gln Arg 
    530                 535                 540                 


Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Val 
545                 550                 555                 560 


Gly Ser Leu Val Val Lys Ser Gly Gln Ser Glu Asp Arg Gln Pro Val 
                565                 570                 575     


Pro Gly Gln Gln Met Xaa Leu Lys Ile Glu Gly Asp His Gly Ala Arg 
            580                 585                 590         


Val Val Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys 
        595                 600                 605             


Asn Lys Leu Xaa Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp 
    610                 615                 620                 


Ile Gly Cys Xaa Pro Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser 
625                 630                 635                 640 


Asp Ala Gly Leu Xaa Phe Xaa Ser Ser Ser Gly Gln Gln Xaa Ala Gln 
                645                 650                 655     


Arg Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser 
            660                 665                 670         


Val Gln Leu Xaa Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro Lys 
        675                 680                 685             


Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met Arg 
    690                 695                 700                 


Phe Ser Cys Gln Arg Arg Xaa Arg Phe Ile Ser Leu Gly Glu Ala Cys 
705                 710                 715                 720 


Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Xaa Glu Leu Arg Arg 
                725                 730                 735     


Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp 
            740                 745                 750         


Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro 
        755                 760                 765             


Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu Pro Pro Lys Asn 
    770                 775                 780                 


Gly Ile Ser Xaa Lys Leu Met Asn Ile Phe Leu Lys Asp Ser Ile Xaa 
785                 790                 795                 800 


Xaa Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys Lys Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Pro Phe Glu Val Xaa Val Met Gln Asp Phe Phe Ile Asp 
            820                 825                 830         


Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg 
        835                 840                 845             


Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val 
    850                 855                 860                 


Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala Xaa Xaa Lys Arg 
865                 870                 875                 880 


Arg His Gln Gln Xaa Val Xaa Ile Pro Pro Lys Ser Ser Leu Ser Val 
                885                 890                 895     


Pro Tyr Val Ile Val Pro Leu Lys Xaa Gly Leu Gln Glu Val Glu Val 
            900                 905                 910         


Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly Val Arg Lys Ser 
        915                 920                 925             


Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys Xaa Val Ala Val 
    930                 935                 940                 


Arg Xaa Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly Val Gln Lys Glu 
945                 950                 955                 960 


Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro Asp Xaa Glu Ser 
                965                 970                 975     


Glu Xaa Arg Ile Leu Leu Gln Gly Xaa Pro Val Ala Gln Met Xaa Glu 
            980                 985                 990         


Asp Ala Val Asp Ala Glu Arg Leu  Lys His Leu Ile Val  Xaa Pro Ser 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Asn Met  Ile Gly Met Xaa Pro  Xaa Val Ile 
    1010                 1015                 1020             


Ala Val  His Tyr Leu Asp Glu  Xaa Glu Gln Trp Glu  Lys Phe Gly 
    1025                 1030                 1035             


Leu Glu  Lys Arg Gln Gly Ala  Leu Glu Leu Ile Lys  Lys Gly Tyr 
    1040                 1045                 1050             


Xaa Gln  Gln Leu Ala Phe Arg  Gln Pro Ser Ser Ala  Phe Ala Ala 
    1055                 1060                 1065             


Phe Val  Lys Arg Ala Pro Ser  Xaa Trp Leu Xaa Ala  Tyr Val Val 
    1070                 1075                 1080             


Lys Val  Phe Ser Leu Ala Val  Asn Leu Ile Ala Ile  Asp Ser Gln 
    1085                 1090                 1095             


Val Leu  Cys Gly Ala Val Lys  Trp Leu Ile Leu Glu  Lys Gln Lys 
    1100                 1105                 1110             


Pro Asp  Gly Val Phe Gln Glu  Asp Ala Pro Val Ile  His Gln Glu 
    1115                 1120                 1125             


Met Ile  Gly Gly Leu Arg Asn  Asn Asn Glu Lys Asp  Met Ala Leu 
    1130                 1135                 1140             


Xaa Ala  Phe Val Leu Ile Ser  Leu Gln Glu Ala Lys  Asp Ile Cys 
    1145                 1150                 1155             


Glu Glu  Gln Val Asn Ser Leu  Pro Gly Ser Ile Xaa  Lys Ala Gly 
    1160                 1165                 1170             


Asp Phe  Leu Glu Ala Asn Tyr  Met Asn Leu Gln Arg  Ser Tyr Xaa 
    1175                 1180                 1185             


Val Ala  Ile Ala Gly Tyr Ala  Leu Ala Gln Met Gly  Arg Leu Lys 
    1190                 1195                 1200             


Gly Pro  Leu Leu Asn Lys Phe  Leu Xaa Xaa Ala Lys  Asp Lys Asn 
    1205                 1210                 1215             


Arg Trp  Glu Asp Pro Gly Lys  Gln Leu Tyr Asn Val  Glu Ala Xaa 
    1220                 1225                 1230             


Ser Tyr  Ala Leu Leu Ala Leu  Leu Gln Leu Lys Asp  Phe Asp Phe 
    1235                 1240                 1245             


Val Pro  Pro Val Val Arg Trp  Leu Asn Glu Gln Arg  Tyr Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Tyr Gly Ser Xaa Gln  Ala Xaa Phe Met Val  Phe Gln Ala 
    1265                 1270                 1275             


Leu Ala  Gln Tyr Gln Lys Asp  Ala Pro Asp His Gln  Glu Leu Asn 
    1280                 1285                 1290             


Leu Asp  Val Ser Leu Gln Leu  Pro Ser Arg Ser Ser  Lys Ile Xaa 
    1295                 1300                 1305             


His Arg  Ile His Trp Glu Ser  Ala Ser Leu Leu Arg  Ser Glu Glu 
    1310                 1315                 1320             


Xaa Lys  Glu Asn Glu Gly Phe  Xaa Val Xaa Ala Glu  Gly Lys Gly 
    1325                 1330                 1335             


Gln Gly  Xaa Leu Ser Val Val  Xaa Met Tyr His Ala  Lys Ala Lys 
    1340                 1345                 1350             


Asp Gln  Leu Xaa Cys Asn Lys  Phe Asp Leu Lys Val  Xaa Ile Lys 
    1355                 1360                 1365             


Pro Ala  Pro Glu Xaa Glu Lys  Arg Pro Gln Asp Ala  Lys Asn Xaa 
    1370                 1375                 1380             


Met Ile  Leu Glu Ile Cys Xaa  Arg Tyr Arg Gly Asp  Gln Asp Ala 
    1385                 1390                 1395             


Xaa Met  Ser Ile Leu Asp Ile  Ser Met Met Xaa Gly  Phe Ala Pro 
    1400                 1405                 1410             


Asp Xaa  Asp Asp Leu Lys Gln  Leu Ala Asn Gly Val  Asp Arg Tyr 
    1415                 1420                 1425             


Ile Ser  Lys Tyr Glu Leu Asp  Lys Ala Phe Ser Asp  Arg Asn Xaa 
    1430                 1435                 1440             


Leu Ile  Ile Tyr Leu Asp Lys  Val Ser His Ser Glu  Asp Asp Cys 
    1445                 1450                 1455             


Leu Ala  Phe Lys Val His Gln  Tyr Phe Asn Val Glu  Leu Ile Gln 
    1460                 1465                 1470             


Pro Gly  Ala Val Lys Val Tyr  Ala Tyr Tyr Asn Leu  Glu Glu Ser 
    1475                 1480                 1485             


Cys Xaa  Arg Phe Tyr His Pro  Glu Lys Glu Asp Gly  Lys Leu Asn 
    1490                 1495                 1500             


Lys Leu  Cys Arg Asp Glu Leu  Cys Arg Cys Ala Glu  Glu Asn Cys 
    1505                 1510                 1515             


Phe Ile  Gln Lys Ser Asp Asp  Lys Val Xaa Leu Glu  Glu Arg Leu 
    1520                 1525                 1530             


Asp Lys  Ala Cys Glu Pro Gly  Val Asp Tyr Val Tyr  Lys Xaa Arg 
    1535                 1540                 1545             


Leu Val  Lys Val Gln Leu Ser  Asn Asp Phe Asp Glu  Tyr Ile Met 
    1550                 1555                 1560             


Ala Ile  Glu Gln Xaa Ile Lys  Ser Gly Ser Asp Glu  Val Gln Val 
    1565                 1570                 1575             


Gly Gln  Gln Arg Xaa Phe Ile  Ser Pro Ile Lys Cys  Arg Glu Ala 
    1580                 1585                 1590             


Leu Lys  Leu Glu Glu Lys Lys  His Tyr Leu Met Trp  Gly Leu Ser 
    1595                 1600                 1605             


Ser Asp  Phe Trp Gly Glu Lys  Pro Asn Leu Ser Tyr  Ile Ile Gly 
    1610                 1615                 1620             


Lys Asp  Xaa Trp Val Glu His  Trp Pro Glu Glu Asp  Glu Cys Gln 
    1625                 1630                 1635             


Asp Glu  Glu Asn Gln Lys Gln  Cys Gln Asp Leu Gly  Ala Phe Xaa 
    1640                 1645                 1650             


Glu Ser  Met Val Val Phe Gly  Cys Pro Asn 
    1655                 1660             


<210> 4574
<211> 103
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 4574
Met Val Leu Glu Ala His Asp Ala Gln Gly Asp Val Pro Val Xaa Val 
1               5                   10                  15      


Xaa Val His Asp Phe Pro Gly Lys Lys Leu Val Leu Ser Ser Glu Lys 
            20                  25                  30          


Xaa Val Leu Xaa Pro Ala Xaa Asn His Met Gly Asn Val Xaa Phe Xaa 
        35                  40                  45              


Ile Pro Ala Asn Arg Glu Phe Lys Ser Glu Lys Gly Arg Asn Lys Phe 
    50                  55                  60                  


Val Xaa Val Gln Ala Xaa Phe Gly Xaa Gln Val Val Glu Lys Val Val 
65                  70                  75                  80  


Leu Val Ser Leu Gln Ser Gly Tyr Leu Phe Ile Gln Xaa Asp Lys Xaa 
                85                  90                  95      


Ile Tyr Xaa Pro Gly Ser Xaa 
            100             


<210> 4575
<211> 101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 4575
Asn Asn Glu Lys Asp Met Ala Leu Xaa Ala Phe Val Leu Ile Ser Leu 
1               5                   10                  15      


Gln Glu Ala Lys Asp Ile Cys Glu Glu Gln Val Asn Ser Leu Pro Gly 
            20                  25                  30          


Ser Ile Xaa Lys Ala Gly Asp Phe Leu Glu Ala Asn Tyr Met Asn Leu 
        35                  40                  45              


Gln Arg Ser Tyr Xaa Val Ala Ile Ala Gly Tyr Ala Leu Ala Gln Met 
    50                  55                  60                  


Gly Arg Leu Lys Gly Pro Leu Leu Asn Lys Phe Leu Xaa Xaa Ala Lys 
65                  70                  75                  80  


Asp Glu Glu Asn Gln Lys Gln Cys Gln Asp Leu Gly Ala Phe Xaa Glu 
                85                  90                  95      


Ser Met Val Val Phe 
            100     


<210> 4576
<211> 100
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 4576
Xaa Phe Ile Gln Lys Ser Asp Asp Lys Val Xaa Leu Glu Glu Arg Leu 
1               5                   10                  15      


Asp Lys Ala Cys Glu Pro Gly Val Asp Tyr Val Tyr Lys Xaa Arg Leu 
            20                  25                  30          


Val Lys Val Gln Leu Ser Asn Asp Phe Asp Glu Tyr Ile Met Ala Ile 
        35                  40                  45              


Glu Gln Xaa Ile Lys Ser Gly Ser Asp Glu Val Gln Val Gly Gln Gln 
    50                  55                  60                  


Arg Xaa Phe Ile Ser Pro Ile Lys Cys Arg Glu Ala Leu Lys Leu Glu 
65                  70                  75                  80  


Glu Lys Lys His Tyr Leu Met Trp Gly Leu Ser Ser Asp Phe Trp Gly 
                85                  90                  95      


Glu Lys Pro Lys 
            100 


<210> 4577
<211> 146
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<400> 4577
Met Ala Ser Phe Ser Ala Glu Xaa Asn Ser Xaa Asp Leu Leu Ser Gln 
1               5                   10                  15      


Pro Trp Asn Glu Pro Pro Val Ile Leu Ser Met Val Ile Leu Ser Leu 
            20                  25                  30          


Xaa Phe Leu Leu Gly Leu Pro Gly Asn Gly Leu Val Leu Trp Val Ala 
        35                  40                  45              


Gly Leu Lys Met Gln Arg Xaa Val Asn Xaa Ile Trp Phe Leu His Leu 
    50                  55                  60                  


Xaa Leu Ala Asp Leu Leu Cys Cys Leu Ser Leu Pro Phe Ser Leu Ala 
65                  70                  75                  80  


His Leu Ala Leu Gln Gly Gln Trp Pro Tyr Gly Arg Phe Leu Cys Lys 
                85                  90                  95      


Leu Ile Pro Ser Ile Ile Val Leu Asn Met Phe Ala Ser Val Phe Leu 
            100                 105                 110         


Leu Xaa Ala Ile Ser Leu Asp Arg Cys Leu Val Val Phe Lys Pro Ile 
        115                 120                 125             


Trp Cys Gln Asn His Arg Asn Val Gly Met Ala Cys Ser Ile Cys Gly 
    130                 135                 140                 


Cys Ile 
145     


<210> 4578
<211> 482
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(481)
<223> Selenocysteine

<400> 4578
Met Ala Ser Phe Ser Ala Glu Xaa Asn Ser Xaa Asp Leu Leu Ser Gln 
1               5                   10                  15      


Pro Trp Asn Glu Pro Pro Val Ile Leu Ser Met Val Ile Leu Ser Leu 
            20                  25                  30          


Xaa Phe Leu Leu Gly Leu Pro Gly Asn Gly Leu Val Leu Trp Val Ala 
        35                  40                  45              


Gly Leu Lys Met Gln Arg Xaa Val Asn Xaa Ile Trp Phe Leu His Leu 
    50                  55                  60                  


Xaa Leu Ala Asp Leu Leu Cys Cys Leu Ser Leu Pro Phe Ser Leu Ala 
65                  70                  75                  80  


His Leu Ala Leu Gln Gly Gln Trp Pro Tyr Gly Arg Phe Leu Cys Lys 
                85                  90                  95      


Leu Ile Pro Ser Ile Ile Val Leu Asn Met Phe Ala Ser Val Phe Leu 
            100                 105                 110         


Leu Xaa Ala Ile Ser Leu Asp Arg Cys Leu Val Val Phe Lys Pro Ile 
        115                 120                 125             


Trp Cys Gln Asn His Arg Asn Val Gly Met Ala Cys Ser Ile Cys Gly 
    130                 135                 140                 


Cys Ile Trp Val Val Ala Phe Val Met Cys Ile Pro Val Phe Val Tyr 
145                 150                 155                 160 


Arg Glu Ile Phe Xaa Xaa Asp Asn His Asn Arg Cys Gly Tyr Lys Phe 
                165                 170                 175     


Gly Leu Ser Ser Ser Leu Asp Tyr Pro Asp Phe Tyr Gly Asp Pro Leu 
            180                 185                 190         


Glu Asn Arg Ser Leu Glu Asn Ile Val Gln Pro Pro Gly Glu Met Asn 
        195                 200                 205             


Asp Arg Leu Asp Pro Ser Ser Phe Gln Xaa Asn Asp His Pro Trp Xaa 
    210                 215                 220                 


Val Pro Xaa Val Phe Gln Pro Gln Xaa Phe Gln Arg Pro Ser Ala Asp 
225                 230                 235                 240 


Ser Leu Pro Arg Gly Ser Ala Arg Leu Xaa Ser Gln Asn Leu Tyr Ser 
                245                 250                 255     


Asn Val Phe Lys Pro Ala Asp Val Val Ser Pro Lys Ile Pro Ser Gly 
            260                 265                 270         


Phe Pro Ile Glu Asp His Glu Xaa Ser Pro Leu Asp Asn Ser Asp Ala 
        275                 280                 285             


Phe Leu Ser Xaa His Leu Lys Leu Phe Pro Ser Ala Ser Ser Asn Ser 
    290                 295                 300                 


Phe Tyr Glu Ser Glu Leu Pro Gln Gly Phe Gln Asp Tyr Tyr Asn Leu 
305                 310                 315                 320 


Gly Gln Phe Xaa Asp Asp Asp Gln Val Pro Xaa Pro Leu Val Ala Ile 
                325                 330                 335     


Xaa Ile Xaa Arg Leu Val Val Gly Phe Leu Leu Pro Ser Val Ile Met 
            340                 345                 350         


Ile Ala Cys Tyr Ser Phe Ile Val Phe Arg Met Gln Arg Gly Arg Phe 
        355                 360                 365             


Ala Lys Ser Gln Ser Lys Xaa Phe Arg Val Ala Val Val Val Val Ala 
    370                 375                 380                 


Val Phe Leu Val Cys Trp Xaa Pro Tyr His Ile Phe Gly Val Leu Ser 
385                 390                 395                 400 


Leu Leu Xaa Asp Pro Glu Xaa Pro Leu Gly Lys Xaa Leu Met Ser Trp 
                405                 410                 415     


Asp His Val Cys Ile Ala Leu Ala Ser Ala Asn Ser Cys Phe Asn Pro 
            420                 425                 430         


Phe Leu Tyr Ala Leu Leu Gly Lys Asp Phe Arg Lys Lys Ala Arg Gln 
        435                 440                 445             


Ser Ile Gln Gly Ile Leu Glu Ala Ala Phe Ser Glu Glu Leu Xaa Arg 
    450                 455                 460                 


Ser Xaa His Cys Pro Ser Asn Asn Val Ile Ser Glu Arg Asn Ser Xaa 
465                 470                 475                 480 


Xaa Val 
        


<210> 4579
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<400> 4579
Met Ala Gly Gln Pro Ala Ala Xaa Gly Ser Pro Ser Ala Asp Lys Asp 
1               5                   10                  15      


Gly Met Glu Pro Asn Val Val Ala Arg Ile Ser Gln Trp Ala Asp Asp 
            20                  25                  30          


His Leu Arg Leu Val Arg Gly His Gly Ile Pro Leu Trp Pro Lys Leu 
        35                  40                  45              


Glu Cys Ser Gly Xaa Ile Ile Ala His Cys Cys Cys Ser Xaa His Phe 
    50                  55                  60                  


Gly Arg Lys Asp Pro Pro Xaa Ser Ala Ser Arg Val Ala Gly Xaa Xaa 
65                  70                  75                  80  


Glu His Gln His Trp Asn Gly His Ser Trp Asn Asn Val Xaa Phe Glu 
                85                  90                  95      


Lys His Ser Xaa Asp Ile Lys Ile Tyr Lys Leu Phe Gly Tyr Ser Ser 
            100                 105                 110         


Arg Ile Tyr Lys Lys Lys Cys 
        115                 


<210> 4580
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<400> 4580
Met Ala Gly Gln Pro Ala Ala Xaa Gly Ser Pro Ser Ala Asp Lys Asp 
1               5                   10                  15      


Gly Met Glu Pro Asn Val Val Ala Arg Ile Ser Gln Trp Ala Asp Asp 
            20                  25                  30          


His Leu Arg Leu Val Arg Asn Ile Ser Xaa Gly Met Ala Ile Ala Gly 
        35                  40                  45              


Ile Met Leu Leu Leu Arg Ser Ile Arg Leu Lys Ser His Val Val Leu 
    50                  55                  60                  


Cys Trp Leu Ser Trp Leu Glu 
65                  70      


<210> 4581
<211> 294
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<400> 4581
Met Ala Gly Gln Pro Ala Ala Xaa Gly Ser Pro Ser Ala Asp Lys Asp 
1               5                   10                  15      


Gly Met Glu Pro Asn Val Val Ala Arg Ile Ser Gln Trp Ala Asp Asp 
            20                  25                  30          


His Leu Arg Leu Val Arg Asn Ile Ser Xaa Gly Met Ala Ile Ala Gly 
        35                  40                  45              


Ile Met Leu Leu Leu Arg Ser Ile Arg Leu Xaa Ser Lys Phe Xaa Ser 
    50                  55                  60                  


Ser Ser Asp Ile Pro Val Glu Phe Ile Arg Arg Asn Val Lys Leu Arg 
65                  70                  75                  80  


Gly Arg Leu Arg Arg Ile Xaa Glu Asn Gly Leu Glu Ile Glu His Ile 
                85                  90                  95      


Pro Ile Xaa Leu Pro Ile Ile Ala Ser Leu Arg Lys Glu Pro Arg Gly 
            100                 105                 110         


Ala Leu Leu Val Lys Leu Ala Gly Val Glu Leu Ala Glu Xaa Gly Lys 
        115                 120                 125             


Ala Trp Leu Gln Lys Glu Leu Lys Pro Ser Gln Leu Leu Trp Phe Gln 
    130                 135                 140                 


Leu Leu Gly Lys Glu Asn Ser Ala Leu Phe Cys Tyr Leu Leu Val Ser 
145                 150                 155                 160 


Lys Gly Gly Tyr Phe Ser Val Asn Leu Asn Glu Glu Ile Leu Arg Arg 
                165                 170                 175     


Gly Leu Gly Lys Xaa Val Leu Val Lys Gly Leu Lys Tyr Asp Ser Lys 
            180                 185                 190         


Ile Tyr Trp Xaa Val His Arg Asn Leu Leu Lys Ala Glu Leu Xaa Ala 
        195                 200                 205             


Leu Lys Lys Gly Glu Gly Ile Trp Lys Glu Asp Ser Glu Lys Glu Ser 
    210                 215                 220                 


Tyr Leu Glu Lys Phe Lys Asp Ser Trp Arg Glu Ile Trp Lys Lys Asp 
225                 230                 235                 240 


Ser Phe Leu Lys Xaa Xaa Gly Ser Asp Phe Ser Leu Lys Lys Glu Ser 
                245                 250                 255     


Tyr Tyr Glu Lys Leu Lys Arg Xaa Tyr Glu Ile Trp Lys Asp Asn Met 
            260                 265                 270         


Asn Asn Cys Ser Leu Ile Leu Lys Phe Arg Glu Leu Ile Ser Arg Ile 
        275                 280                 285             


Asn Phe Arg Arg Lys Gly 
    290                 


<210> 4582
<211> 251
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<400> 4582
Met Ala Ile Ala Gly Ile Met Leu Leu Leu Arg Ser Ile Arg Leu Xaa 
1               5                   10                  15      


Ser Lys Phe Xaa Ser Ser Ser Asp Ile Pro Val Glu Phe Ile Arg Arg 
            20                  25                  30          


Asn Val Lys Leu Arg Gly Arg Leu Arg Arg Ile Xaa Glu Asn Gly Leu 
        35                  40                  45              


Glu Ile Glu His Ile Pro Ile Xaa Leu Pro Ile Ile Ala Ser Leu Arg 
    50                  55                  60                  


Lys Glu Pro Arg Gly Ala Leu Leu Val Lys Leu Ala Gly Val Glu Leu 
65                  70                  75                  80  


Ala Glu Xaa Gly Lys Ala Trp Leu Gln Lys Glu Leu Lys Pro Ser Gln 
                85                  90                  95      


Leu Leu Trp Phe Gln Leu Leu Gly Lys Glu Asn Ser Ala Leu Phe Cys 
            100                 105                 110         


Tyr Leu Leu Val Ser Lys Gly Gly Tyr Phe Ser Val Asn Leu Asn Glu 
        115                 120                 125             


Glu Ile Leu Arg Arg Gly Leu Gly Lys Xaa Val Leu Val Lys Gly Leu 
    130                 135                 140                 


Lys Tyr Asp Ser Lys Ile Tyr Trp Xaa Val His Arg Asn Leu Leu Lys 
145                 150                 155                 160 


Ala Glu Leu Xaa Ala Leu Lys Lys Gly Glu Gly Ile Trp Lys Glu Asp 
                165                 170                 175     


Ser Glu Lys Glu Ser Tyr Leu Glu Lys Phe Lys Asp Ser Trp Arg Glu 
            180                 185                 190         


Ile Trp Lys Lys Asp Ser Phe Leu Lys Xaa Xaa Gly Ser Asp Phe Ser 
        195                 200                 205             


Leu Lys Lys Glu Ser Tyr Tyr Glu Lys Leu Lys Arg Xaa Tyr Glu Ile 
    210                 215                 220                 


Trp Lys Asp Asn Met Asn Asn Cys Ser Leu Ile Leu Lys Phe Arg Glu 
225                 230                 235                 240 


Leu Ile Ser Arg Ile Asn Phe Arg Arg Lys Gly 
                245                 250     


<210> 4583
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<400> 4583
Xaa Ala Gly Gln Pro Ala Ala Xaa Gly Ser Pro Ser Ala Asp Lys Asp 
1               5                   10                  15      


Gly Met Glu Pro Asn Val Val Ala Arg Ile Ser Gln Trp Ala Asp Asp 
            20                  25                  30          


His Leu Arg Leu Val Arg Gly His Gly Ile Pro Leu Trp Pro Lys Leu 
        35                  40                  45              


Glu Cys Ser Gly Xaa Ile Ile Ala His Cys Cys Cys Ser Xaa His Phe 
    50                  55                  60                  


Gly Arg Lys Asp Pro Pro Xaa Ser Ala Ser Arg Val Ala Gly Xaa Xaa 
65                  70                  75                  80  


Asp Gln Val Leu His Leu Ser Pro Arg Leu Glu Cys Asn Gly Val Ile 
                85                  90                  95      


Ser Ala His Cys Asn Leu Cys Leu Pro Gly Ser Ser Asp Cys Pro Ala 
            100                 105                 110         


Ser Pro Ser 
        115 


<210> 4584
<211> 213
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<400> 4584
Met Glu Ser Leu Leu Leu Leu Pro Arg Phe Gly Arg Ile Ser Asp Leu 
1               5                   10                  15      


Xaa Val Asp Leu Ser Xaa Pro Glu Gly Ser Phe Pro Ser Asp Glu Gly 
            20                  25                  30          


Trp Pro Phe Ala Lys Tyr Leu Gly Ala Cys Gly Arg Met Val Ala Val 
        35                  40                  45              


Asn Tyr Val Gly Glu Glu Leu Trp Ser Tyr Phe Asn Ala Pro Trp Glu 
    50                  55                  60                  


Lys Arg Val Asp Leu Ala Trp Gln Leu Met Glu Ile Ala Glu Gln Leu 
65                  70                  75                  80  


Xaa Asn Asn Asp Phe Glu Phe Ala Leu Tyr Leu Leu Asp Val Ser Phe 
                85                  90                  95      


Asp Asn Phe Ala Val Gly Pro Arg Asp Gly Lys Val Ile Ile Val Asp 
            100                 105                 110         


Ala Glu Asn Val Leu Val Ala Asp Lys Arg Leu Ile Arg Gln Asn Lys 
        115                 120                 125             


Pro Glu Asn Trp Asp Val Trp Tyr Glu Ser Lys Phe Asp Asp Cys Asp 
    130                 135                 140                 


Lys Glu Ala Cys Leu Ser Phe Ser Lys Glu Ile Leu Cys Ala Arg Ala 
145                 150                 155                 160 


Xaa Val Asp His Asn Tyr Tyr Ala Val Cys Gln Asn Leu Leu Ser Arg 
                165                 170                 175     


His Ala Xaa Trp Arg Gly Xaa Ser Gly Gly Leu Leu His Asp Pro Pro 
            180                 185                 190         


Ser Glu Ile Ala Lys Asp Gly Arg Leu Glu Ala Leu Leu Asp Glu Cys 
        195                 200                 205             


Ala Asn Pro Lys Lys 
    210             


<210> 4585
<211> 221
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<400> 4585
Met Lys Ser Glu Asn Gly Xaa Val Val Gly Ser Phe Pro Ser Asp Glu 
1               5                   10                  15      


Gly Trp Pro Phe Ala Lys Tyr Leu Gly Ala Cys Gly Arg Met Val Ala 
            20                  25                  30          


Val Asn Tyr Val Gly Glu Glu Leu Trp Ser Tyr Phe Asn Ala Pro Trp 
        35                  40                  45              


Glu Lys Arg Val Asp Leu Ala Trp Gln Leu Met Glu Ile Ala Glu Gln 
    50                  55                  60                  


Leu Xaa Asn Asn Asp Phe Glu Phe Ala Leu Tyr Leu Leu Asp Val Ser 
65                  70                  75                  80  


Phe Asp Asn Phe Ala Val Gly Pro Arg Asp Gly Lys Val Ile Ile Val 
                85                  90                  95      


Asp Ala Glu Asn Val Leu Val Ala Asp Lys Arg Leu Ile Arg Gln Asn 
            100                 105                 110         


Lys Pro Glu Asn Trp Asp Val Trp Tyr Glu Ser Lys Phe Asp Asp Cys 
        115                 120                 125             


Asp Lys Glu Ala Cys Leu Ser Phe Ser Lys Glu Ile Leu Cys Ala Arg 
    130                 135                 140                 


Ala Xaa Val Asp His Asn Tyr Tyr Ala Val Cys Gln Asn Leu Leu Ser 
145                 150                 155                 160 


Arg His Ala Xaa Trp Arg Gly Xaa Ser Gly Gly Leu Leu His Asp Pro 
                165                 170                 175     


Pro Ser Glu Ile Ala Lys Asp Gly Arg Leu Glu Ala Leu Leu Asp Glu 
            180                 185                 190         


Cys Ala Asn Pro Lys Lys Arg Tyr Gly Arg Phe Gln Ala Ala Lys Glu 
        195                 200                 205             


Leu Arg Glu Tyr Leu Ala Gln Leu Ser Asn Asn Val Arg 
    210                 215                 220     


<210> 4586
<211> 192
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<400> 4586
Met Val Ala Val Asn Tyr Val Gly Glu Glu Leu Trp Ser Tyr Phe Asn 
1               5                   10                  15      


Ala Pro Trp Glu Lys Arg Val Asp Leu Ala Trp Gln Leu Met Glu Ile 
            20                  25                  30          


Ala Glu Gln Leu Xaa Asn Asn Asp Phe Glu Phe Ala Leu Tyr Leu Leu 
        35                  40                  45              


Asp Val Ser Phe Asp Asn Phe Ala Val Gly Pro Arg Asp Gly Lys Val 
    50                  55                  60                  


Ile Ile Val Asp Ala Glu Asn Val Leu Val Ala Asp Lys Arg Leu Ile 
65                  70                  75                  80  


Arg Gln Asn Lys Pro Glu Asn Trp Asp Val Trp Tyr Glu Ser Lys Phe 
                85                  90                  95      


Asp Asp Cys Asp Lys Glu Ala Cys Leu Ser Phe Ser Lys Glu Ile Leu 
            100                 105                 110         


Cys Ala Arg Ala Xaa Val Asp His Asn Tyr Tyr Ala Val Cys Gln Asn 
        115                 120                 125             


Leu Leu Ser Arg His Ala Xaa Trp Arg Gly Xaa Ser Gly Gly Leu Leu 
    130                 135                 140                 


His Asp Pro Pro Ser Glu Ile Ala Lys Asp Gly Arg Leu Glu Ala Leu 
145                 150                 155                 160 


Leu Asp Glu Cys Ala Asn Pro Lys Lys Arg Tyr Gly Arg Phe Gln Ala 
                165                 170                 175     


Ala Lys Glu Leu Arg Glu Tyr Leu Ala Gln Leu Ser Asn Asn Val Arg 
            180                 185                 190         


<210> 4587
<211> 430
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<400> 4587
Met Trp Arg Leu Val Pro Pro Lys Leu Gly Arg Leu Ser Arg Ser Leu 
1               5                   10                  15      


Lys Leu Ala Ala Leu Gly Ser Leu Leu Val Leu Met Val Leu His Ser 
            20                  25                  30          


Pro Ser Leu Leu Ala Ser Trp Gln Arg Asn Glu Leu Xaa Asp Arg Arg 
        35                  40                  45              


Phe Leu Gln Leu Asn Lys Cys Pro Ala Cys Phe Gly Xaa Ser Trp Cys 
    50                  55                  60                  


Arg Arg Phe Leu Asn Gly Gln Val Val Phe Glu Ala Trp Gly Arg Leu 
65                  70                  75                  80  


Arg Leu Leu Asp Phe Leu Asn Val Lys Asn Val Tyr Phe Ala Gln Tyr 
                85                  90                  95      


Gly Glu Pro Arg Glu Gly Gly Arg Arg Arg Val Val Leu Lys Arg Leu 
            100                 105                 110         


Gly Ser Gln Arg Glu Leu Ala Gln Leu Asp Gln Ser Ile Cys Lys Arg 
        115                 120                 125             


Ala Xaa Gly Arg Pro Arg Cys Asp Leu Leu Gln Ala Met Pro Arg Xaa 
    130                 135                 140                 


Glu Phe Ala Arg Leu Asn Gly Asp Val Arg Leu Leu Xaa Pro Glu Ala 
145                 150                 155                 160 


Val Glu Gly Trp Ser Asp Leu Val His Cys Pro Ser Gln Arg Leu Leu 
                165                 170                 175     


Asp Arg Leu Val Arg Arg Tyr Ala Glu Xaa Lys Asp Ser Gly Ser Phe 
            180                 185                 190         


Leu Leu Arg Asn Leu Lys Asp Ser Glu Arg Met Gln Leu Leu Leu Xaa 
        195                 200                 205             


Leu Ala Phe Asn Pro Glu Pro Leu Val Leu Gln Ser Phe Pro Ser Asp 
    210                 215                 220                 


Glu Gly Trp Pro Phe Ala Lys Tyr Leu Gly Ala Cys Gly Arg Met Val 
225                 230                 235                 240 


Ala Val Asn Tyr Val Gly Glu Glu Leu Trp Ser Tyr Phe Asn Ala Pro 
                245                 250                 255     


Trp Glu Lys Arg Val Asp Leu Ala Trp Gln Leu Met Glu Ile Ala Glu 
            260                 265                 270         


Gln Leu Xaa Asn Asn Asp Phe Glu Phe Ala Leu Tyr Leu Leu Asp Val 
        275                 280                 285             


Ser Phe Asp Asn Phe Ala Val Gly Pro Arg Asp Gly Lys Val Ile Ile 
    290                 295                 300                 


Val Asp Ala Glu Asn Val Leu Val Ala Asp Lys Arg Leu Ile Arg Gln 
305                 310                 315                 320 


Asn Lys Pro Glu Asn Trp Asp Val Trp Tyr Glu Ser Lys Phe Asp Asp 
                325                 330                 335     


Cys Asp Lys Glu Ala Cys Leu Ser Phe Ser Lys Glu Ile Leu Cys Ala 
            340                 345                 350         


Arg Ala Xaa Val Asp His Asn Tyr Tyr Ala Val Cys Gln Asn Leu Leu 
        355                 360                 365             


Ser Arg His Ala Xaa Trp Arg Gly Xaa Ser Gly Gly Leu Leu His Asp 
    370                 375                 380                 


Pro Pro Ser Glu Ile Ala Lys Asp Gly Arg Leu Glu Ala Leu Leu Asp 
385                 390                 395                 400 


Glu Cys Ala Asn Pro Lys Lys Arg Tyr Gly Arg Phe Gln Ala Ala Lys 
                405                 410                 415     


Glu Leu Arg Glu Tyr Leu Ala Gln Leu Ser Asn Asn Val Arg 
            420                 425                 430 


<210> 4588
<211> 1676
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1145)..(1145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1179)..(1179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1187)..(1187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1244)..(1244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1287)..(1287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1298)..(1298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1368)..(1368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1383)..(1383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1430)..(1430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1451)..(1451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1492)..(1492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1494)..(1494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1511)..(1511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1551)..(1551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1566)..(1566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1569)..(1569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1580)..(1580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1587)..(1587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1599)..(1599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1605)..(1605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1643)..(1643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1652)..(1653)
<223> Selenocysteine

<400> 4588
Met Gly Leu Leu Gly Ile Leu Cys Phe Leu Ile Phe Leu Gly Lys Xaa 
1               5                   10                  15      


Trp Gly Gln Glu Gln Xaa Tyr Val Ile Ser Ala Pro Lys Ile Phe Arg 
            20                  25                  30          


Val Gly Ala Ser Glu Asn Ile Val Ile Gln Val Tyr Gly Tyr Xaa Glu 
        35                  40                  45              


Ala Phe Asp Ala Xaa Ile Ser Ile Lys Ser Tyr Pro Asp Lys Lys Phe 
    50                  55                  60                  


Ser Tyr Ser Ser Gly His Val His Leu Ser Ser Glu Asn Lys Phe Gln 
65                  70                  75                  80  


Asn Ser Ala Ile Leu Xaa Ile Gln Pro Lys Gln Leu Pro Gly Gly Gln 
                85                  90                  95      


Asn Pro Val Ser Tyr Val Tyr Leu Glu Val Val Ser Lys His Phe Ser 
            100                 105                 110         


Lys Ser Lys Arg Met Pro Ile Xaa Tyr Asp Asn Gly Phe Leu Phe Ile 
        115                 120                 125             


His Xaa Asp Lys Pro Val Tyr Xaa Pro Asp Gln Ser Val Lys Val Arg 
    130                 135                 140                 


Val Tyr Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Xaa Val 
145                 150                 155                 160 


Leu Xaa Phe Ile Asp Pro Glu Gly Ser Glu Val Asp Met Val Glu Glu 
                165                 170                 175     


Ile Asp His Ile Gly Ile Ile Ser Phe Pro Asp Phe Lys Ile Pro Ser 
            180                 185                 190         


Asn Pro Arg Tyr Gly Met Trp Xaa Ile Lys Ala Lys Tyr Lys Glu Asp 
        195                 200                 205             


Phe Ser Xaa Xaa Gly Xaa Ala Tyr Phe Glu Val Lys Glu Tyr Val Leu 
    210                 215                 220                 


Pro His Phe Ser Val Ser Ile Glu Pro Glu Tyr Asn Phe Ile Gly Tyr 
225                 230                 235                 240 


Lys Asn Phe Lys Asn Phe Glu Ile Xaa Ile Lys Ala Arg Tyr Phe Tyr 
                245                 250                 255     


Asn Lys Val Val Xaa Glu Ala Asp Val Tyr Ile Xaa Phe Gly Ile Arg 
            260                 265                 270         


Glu Asp Leu Lys Asp Asp Gln Lys Glu Met Met Gln Xaa Ala Met Gln 
        275                 280                 285             


Asn Xaa Met Leu Ile Asn Gly Ile Ala Gln Val Xaa Phe Asp Ser Glu 
    290                 295                 300                 


Xaa Ala Val Lys Glu Leu Ser Tyr Tyr Ser Leu Glu Asp Leu Asn Asn 
305                 310                 315                 320 


Lys Tyr Leu Tyr Ile Ala Val Xaa Val Ile Glu Ser Xaa Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Ala Glu Ile Pro Gly Ile Lys Tyr Val Leu Ser Pro Tyr 
            340                 345                 350         


Lys Leu Asn Leu Val Ala Xaa Pro Leu Phe Leu Lys Pro Gly Ile Pro 
        355                 360                 365             


Tyr Pro Ile Lys Val Gln Val Lys Asp Ser Leu Asp Gln Leu Val Gly 
    370                 375                 380                 


Gly Val Pro Val Xaa Leu Asn Ala Gln Xaa Ile Asp Val Asn Gln Glu 
385                 390                 395                 400 


Xaa Ser Asp Leu Asp Pro Ser Lys Ser Val Xaa Arg Val Asp Asp Gly 
                405                 410                 415     


Val Ala Ser Phe Val Leu Asn Leu Pro Ser Gly Val Xaa Val Leu Glu 
            420                 425                 430         


Phe Asn Val Lys Xaa Asp Ala Pro Asp Leu Pro Glu Glu Asn Gln Ala 
        435                 440                 445             


Arg Glu Gly Tyr Arg Ala Ile Ala Tyr Ser Ser Leu Ser Gln Ser Tyr 
    450                 455                 460                 


Leu Tyr Ile Asp Trp Xaa Asp Asn His Lys Ala Leu Leu Val Gly Glu 
465                 470                 475                 480 


His Leu Asn Ile Ile Val Xaa Pro Lys Ser Pro Tyr Ile Asp Lys Ile 
                485                 490                 495     


Xaa His Tyr Asn Tyr Leu Ile Leu Ser Lys Gly Lys Ile Ile His Phe 
            500                 505                 510         


Gly Xaa Arg Glu Lys Phe Ser Asp Ala Ser Tyr Gln Ser Ile Asn Ile 
        515                 520                 525             


Pro Val Xaa Gln Asn Met Val Pro Ser Ser Arg Leu Leu Val Tyr Tyr 
    530                 535                 540                 


Ile Val Xaa Gly Glu Gln Xaa Ala Glu Leu Val Ser Asp Ser Val Trp 
545                 550                 555                 560 


Leu Asn Ile Glu Glu Lys Cys Gly Asn Gln Leu Gln Val His Leu Ser 
                565                 570                 575     


Pro Asp Ala Asp Ala Tyr Ser Pro Gly Gln Xaa Val Ser Leu Asn Met 
            580                 585                 590         


Ala Xaa Gly Met Asp Ser Trp Val Ala Leu Ala Ala Val Asp Ser Ala 
        595                 600                 605             


Val Tyr Gly Val Gln Arg Gly Ala Lys Lys Pro Leu Glu Arg Val Phe 
    610                 615                 620                 


Gln Phe Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu 
625                 630                 635                 640 


Asn Asn Ala Asn Val Phe His Leu Ala Gly Leu Xaa Phe Leu Xaa Asn 
                645                 650                 655     


Ala Asn Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro Cys Lys Glu Ile 
            660                 665                 670         


Leu Arg Pro Arg Arg Xaa Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala 
        675                 680                 685             


Lys Tyr Lys His Ser Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys 
    690                 695                 700                 


Val Asn Asn Asp Glu Xaa Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu 
705                 710                 715                 720 


Gly Pro Arg Cys Ile Lys Ala Phe Xaa Glu Cys Cys Val Val Ala Ser 
                725                 730                 735     


Gln Leu Arg Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Arg Leu 
            740                 745                 750         


His Met Lys Xaa Leu Leu Pro Val Ser Lys Pro Glu Ile Arg Ser Tyr 
        755                 760                 765             


Phe Pro Glu Ser Trp Leu Trp Glu Val His Leu Val Pro Arg Arg Lys 
    770                 775                 780                 


Gln Leu Gln Phe Ala Leu Pro Asp Ser Leu Xaa Xaa Trp Glu Ile Gln 
785                 790                 795                 800 


Gly Val Gly Ile Ser Asn Xaa Gly Ile Cys Val Ala Asp Xaa Val Lys 
                805                 810                 815     


Ala Lys Val Phe Lys Asp Val Phe Leu Glu Met Asn Ile Pro Tyr Ser 
            820                 825                 830         


Val Val Arg Gly Glu Gln Ile Gln Leu Lys Gly Xaa Val Tyr Asn Tyr 
        835                 840                 845             


Arg Xaa Ser Gly Met Gln Phe Cys Val Lys Met Ser Ala Val Glu Gly 
    850                 855                 860                 


Ile Cys Xaa Ser Glu Ser Pro Val Ile Asp His Gln Gly Xaa Lys Ser 
865                 870                 875                 880 


Ser Lys Cys Val Arg Gln Lys Val Glu Gly Ser Ser Ser His Leu Val 
                885                 890                 895     


Xaa Phe Xaa Val Leu Pro Leu Glu Ile Gly Leu His Asn Ile Asn Phe 
            900                 905                 910         


Ser Leu Glu Xaa Trp Phe Gly Lys Glu Ile Leu Val Lys Xaa Leu Arg 
        915                 920                 925             


Val Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly Val Xaa Leu 
    930                 935                 940                 


Asp Pro Arg Gly Ile Tyr Gly Xaa Ile Ser Arg Arg Lys Glu Phe Pro 
945                 950                 955                 960 


Tyr Arg Ile Pro Leu Asp Leu Val Pro Lys Xaa Glu Ile Lys Arg Ile 
                965                 970                 975     


Leu Ser Val Lys Gly Leu Leu Val Gly Glu Ile Leu Ser Ala Val Leu 
            980                 985                 990         


Ser Gln Glu Gly Ile Asn Ile Leu  Xaa His Leu Pro Lys  Gly Ser Ala 
        995                 1000                 1005             


Glu Ala  Glu Leu Met Ser Val  Val Pro Val Phe Tyr  Val Phe His 
    1010                 1015                 1020             


Tyr Leu  Glu Xaa Gly Asn His  Trp Asn Ile Phe His  Ser Asp Pro 
    1025                 1030                 1035             


Leu Ile  Glu Lys Gln Lys Leu  Lys Lys Lys Leu Lys  Glu Gly Met 
    1040                 1045                 1050             


Leu Ser  Ile Met Ser Tyr Arg  Asn Ala Asp Tyr Ser  Tyr Ser Val 
    1055                 1060                 1065             


Trp Lys  Gly Gly Ser Ala Ser  Xaa Trp Leu Xaa Ala  Phe Ala Leu 
    1070                 1075                 1080             


Arg Val  Leu Gly Gln Val Asn  Lys Tyr Val Glu Gln  Asn Gln Asn 
    1085                 1090                 1095             


Ser Ile  Cys Asn Ser Leu Leu  Trp Leu Val Glu Asn  Tyr Gln Leu 
    1100                 1105                 1110             


Asp Asn  Gly Ser Phe Lys Glu  Asn Ser Gln Tyr Gln  Pro Ile Lys 
    1115                 1120                 1125             


Leu Gln  Gly Xaa Leu Pro Val  Glu Ala Arg Glu Asn  Ser Leu Tyr 
    1130                 1135                 1140             


Leu Xaa  Ala Phe Xaa Val Ile  Gly Ile Arg Lys Ala  Phe Asp Ile 
    1145                 1150                 1155             


Cys Pro  Leu Val Lys Ile Asp  Xaa Ala Leu Ile Lys  Ala Asp Asn 
    1160                 1165                 1170             


Phe Leu  Leu Glu Asn Xaa Leu  Pro Ala Gln Ser Xaa  Phe Xaa Leu 
    1175                 1180                 1185             


Ala Ile  Ser Ala Tyr Ala Leu  Ser Leu Gly Asp Lys  Xaa His Pro 
    1190                 1195                 1200             


Gln Phe  Arg Ser Ile Val Ser  Ala Leu Lys Arg Glu  Ala Leu Val 
    1205                 1210                 1215             


Lys Gly  Asn Pro Pro Ile Tyr  Arg Phe Trp Lys Asp  Asn Leu Gln 
    1220                 1225                 1230             


His Lys  Asp Ser Ser Val Pro  Asn Xaa Gly Xaa Ala  Arg Met Val 
    1235                 1240                 1245             


Glu Xaa  Xaa Ala Tyr Ala Leu  Leu Xaa Ser Leu Asn  Leu Lys Asp 
    1250                 1255                 1260             


Ile Asn  Tyr Val Asn Pro Val  Ile Lys Trp Leu Ser  Glu Glu Gln 
    1265                 1270                 1275             


Arg Tyr  Gly Gly Gly Phe Tyr  Ser Xaa Gln Asp Xaa  Ile Asn Ala 
    1280                 1285                 1290             


Ile Glu  Gly Leu Xaa Glu Tyr  Ser Leu Leu Val Lys  Gln Leu Arg 
    1295                 1300                 1305             


Leu Ser  Met Asp Ile Asp Val  Ser Tyr Lys His Lys  Gly Ala Leu 
    1310                 1315                 1320             


His Asn  Tyr Lys Met Xaa Asp  Lys Asn Phe Leu Gly  Arg Pro Val 
    1325                 1330                 1335             


Glu Val  Leu Leu Asn Asp Asp  Leu Ile Val Ser Xaa  Gly Phe Gly 
    1340                 1345                 1350             


Ser Gly  Leu Ala Xaa Val His  Val Xaa Xaa Val Val  His Lys Xaa 
    1355                 1360                 1365             


Ser Xaa  Ser Glu Glu Val Cys  Ser Phe Tyr Leu Lys  Ile Asp Xaa 
    1370                 1375                 1380             


Gln Asp  Ile Glu Ala Ser His  Tyr Arg Gly Tyr Gly  Asn Ser Asp 
    1385                 1390                 1395             


Tyr Lys  Arg Ile Val Ala Cys  Ala Ser Tyr Lys Pro  Ser Arg Glu 
    1400                 1405                 1410             


Glu Ser  Ser Ser Gly Ser Ser  His Ala Val Met Asp  Ile Ser Leu 
    1415                 1420                 1425             


Pro Xaa  Gly Ile Ser Ala Asn  Glu Glu Asp Leu Lys  Ala Leu Val 
    1430                 1435                 1440             


Glu Gly  Val Asp Gln Leu Phe  Xaa Asp Tyr Gln Ile  Lys Asp Gly 
    1445                 1450                 1455             


His Val  Ile Leu Gln Leu Asn  Ser Ile Pro Ser Ser  Asp Phe Leu 
    1460                 1465                 1470             


Cys Val  Arg Phe Arg Ile Phe  Glu Leu Phe Glu Val  Gly Phe Leu 
    1475                 1480                 1485             


Ser Pro  Ala Xaa Phe Xaa Val  Tyr Glu Tyr His Arg  Pro Asp Lys 
    1490                 1495                 1500             


Gln Cys  Xaa Met Phe Tyr Ser  Xaa Ser Asn Ile Lys  Ile Gln Lys 
    1505                 1510                 1515             


Val Cys  Glu Gly Ala Ala Cys  Lys Cys Val Glu Ala  Asp Cys Gly 
    1520                 1525                 1530             


Gln Met  Gln Glu Glu Leu Asp  Leu Xaa Ile Ser Ala  Glu Xaa Arg 
    1535                 1540                 1545             


Lys Gln  Xaa Ala Cys Lys Pro  Glu Ile Ala Tyr Ala  Tyr Lys Val 
    1550                 1555                 1560             


Ser Ile  Xaa Ser Ile Xaa Val  Glu Asn Val Phe Val  Lys Tyr Lys 
    1565                 1570                 1575             


Ala Xaa  Leu Leu Asp Ile Tyr  Lys Xaa Gly Glu Ala  Val Ala Glu 
    1580                 1585                 1590             


Lys Asp  Ser Glu Ile Xaa Phe  Ile Lys Lys Val Xaa  Cys Xaa Asn 
    1595                 1600                 1605             


Ala Glu  Leu Val Lys Gly Arg  Gln Tyr Leu Ile Met  Gly Lys Glu 
    1610                 1615                 1620             


Ala Leu  Gln Ile Lys Tyr Asn  Phe Ser Phe Arg Tyr  Ile Tyr Pro 
    1625                 1630                 1635             


Leu Asp  Ser Leu Xaa Trp Ile  Glu Tyr Trp Pro Arg  Asp Xaa Xaa 
    1640                 1645                 1650             


Cys Ser  Ser Cys Gln Ala Phe  Leu Ala Asn Leu Asp  Glu Phe Ala 
    1655                 1660                 1665             


Glu Asp  Ile Phe Leu Asn Gly  Cys 
    1670                 1675     


<210> 4589
<211> 350
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<400> 4589
Met Asp Ser Phe Asn Tyr Xaa Xaa Pro Asp Tyr Gly His Tyr Asp Asp 
1               5                   10                  15      


Lys Asp Xaa Leu Asp Leu Asn Xaa Pro Val Asp Lys Xaa Ser Asn Xaa 
            20                  25                  30          


Leu Arg Val Pro Asp Ile Leu Ala Leu Val Ile Phe Ala Val Val Phe 
        35                  40                  45              


Leu Val Gly Val Leu Gly Asn Ala Leu Val Val Trp Val Xaa Ala Phe 
    50                  55                  60                  


Glu Ala Lys Arg Xaa Ile Asn Ala Ile Trp Phe Leu Asn Leu Ala Val 
65                  70                  75                  80  


Ala Asp Phe Leu Ser Cys Leu Ala Leu Pro Ile Leu Phe Xaa Ser Ile 
                85                  90                  95      


Val Gln His His His Trp Pro Phe Gly Gly Ala Ala Cys Ser Ile Leu 
            100                 105                 110         


Pro Ser Leu Ile Leu Leu Asn Met Tyr Ala Ser Ile Leu Leu Leu Ala 
        115                 120                 125             


Xaa Ile Ser Ala Asp Arg Phe Leu Leu Val Phe Lys Pro Ile Trp Cys 
    130                 135                 140                 


Gln Asn Phe Arg Gly Ala Gly Leu Ala Trp Ile Ala Cys Ala Val Ala 
145                 150                 155                 160 


Trp Gly Leu Ala Leu Leu Leu Xaa Ile Pro Ser Phe Leu Tyr Arg Val 
                165                 170                 175     


Val Arg Glu Glu Tyr Phe Pro Pro Lys Val Leu Cys Gly Val Asp Tyr 
            180                 185                 190         


Ser His Asp Lys Arg Arg Glu Arg Ala Val Ala Ile Val Arg Leu Val 
        195                 200                 205             


Leu Gly Phe Leu Trp Pro Leu Leu Xaa Leu Xaa Ile Cys Tyr Xaa Phe 
    210                 215                 220                 


Ile Leu Leu Arg Xaa Trp Ser Arg Arg Ala Xaa Arg Ser Xaa Lys Xaa 
225                 230                 235                 240 


Leu Lys Val Val Val Ala Val Val Ala Ser Phe Phe Ile Phe Trp Leu 
                245                 250                 255     


Pro Tyr Gln Val Xaa Gly Ile Met Met Ser Phe Leu Glu Pro Ser Ser 
            260                 265                 270         


Pro Xaa Phe Leu Leu Leu Lys Lys Leu Asp Ser Leu Cys Val Ser Phe 
        275                 280                 285             


Ala Tyr Ile Asn Cys Cys Ile Asn Pro Ile Ile Tyr Val Val Ala Gly 
    290                 295                 300                 


Gln Gly Phe Gln Gly Arg Leu Arg Lys Ser Leu Pro Ser Leu Leu Arg 
305                 310                 315                 320 


Asn Val Leu Xaa Glu Glu Ser Val Val Arg Glu Ser Lys Ser Phe Xaa 
                325                 330                 335     


Arg Ser Xaa Val Asp Xaa Met Ala Gln Lys Xaa Gln Ala Val 
            340                 345                 350 


<210> 4590
<211> 17
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<400> 4590
Met Tyr Ala Ser Ile Leu Leu Leu Ala Xaa Ile Ser Ala Asp Arg Phe 
1               5                   10                  15      


Leu 
    


<210> 4591
<211> 337
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<400> 4591
Met Gly Asn Asp Ser Val Ser Tyr Glu Tyr Gly Asp Tyr Ser Asp Leu 
1               5                   10                  15      


Ser Asp Arg Pro Val Asp Cys Leu Asp Gly Ala Cys Leu Ala Ile Asp 
            20                  25                  30          


Pro Leu Arg Val Ala Pro Leu Pro Leu Tyr Ala Ala Ile Phe Leu Val 
        35                  40                  45              


Gly Val Pro Gly Asn Ala Met Val Ala Trp Val Ala Gly Lys Val Ala 
    50                  55                  60                  


Arg Arg Arg Val Gly Ala Xaa Trp Leu Leu His Leu Ala Val Ala Asp 
65                  70                  75                  80  


Leu Leu Cys Cys Leu Ser Leu Pro Ile Leu Ala Val Pro Ile Ala Arg 
                85                  90                  95      


Gly Gly His Trp Pro Tyr Gly Ala Val Gly Cys Arg Ala Leu Pro Ser 
            100                 105                 110         


Ile Ile Leu Leu Xaa Met Tyr Ala Ser Val Leu Leu Leu Ala Ala Leu 
        115                 120                 125             


Ser Ala Asp Leu Cys Phe Leu Ala Leu Gly Pro Ala Trp Trp Ser Xaa 
    130                 135                 140                 


Val Gln Arg Ala Cys Gly Val Gln Val Ala Cys Gly Ala Ala Trp Xaa 
145                 150                 155                 160 


Leu Ala Leu Leu Leu Xaa Val Pro Ser Ala Ile Tyr Arg Arg Leu His 
                165                 170                 175     


Gln Glu His Phe Pro Ala Arg Leu Gln Cys Val Val Asp Tyr Gly Gly 
            180                 185                 190         


Ser Ser Ser Xaa Glu Asn Ala Val Xaa Ala Ile Arg Phe Leu Phe Gly 
        195                 200                 205             


Phe Leu Gly Pro Leu Val Ala Val Ala Ser Cys His Ser Ala Leu Leu 
    210                 215                 220                 


Cys Trp Ala Ala Arg Arg Cys Arg Pro Leu Gly Xaa Ala Ile Val Val 
225                 230                 235                 240 


Gly Phe Phe Val Cys Trp Ala Pro Tyr His Leu Leu Gly Leu Val Leu 
                245                 250                 255     


Xaa Val Ala Ala Pro Asn Ser Ala Leu Leu Ala Arg Ala Leu Arg Ala 
            260                 265                 270         


Glu Pro Leu Ile Val Gly Leu Ala Leu Ala His Ser Cys Leu Asn Pro 
        275                 280                 285             


Met Leu Phe Leu Tyr Phe Gly Arg Ala Gln Leu Arg Arg Ser Leu Pro 
    290                 295                 300                 


Ala Ala Cys His Trp Ala Leu Arg Glu Ser Gln Gly Gln Asp Glu Ser 
305                 310                 315                 320 


Val Asp Ser Lys Lys Ser Xaa Ser His Asp Leu Val Ser Glu Met Glu 
                325                 330                 335     


Val 
    


<210> 4592
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(124)
<223> Selenocysteine

<400> 4592
Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Xaa Pro Xaa Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Ala Pro Asp Pro Ala Ala Gly 
                85                  90                  95      


Arg Trp Val Gly Ala Arg Xaa Gly Ser Phe Gly Pro Gly Leu Val Ala 
            100                 105                 110         


Ala Gln Ala Pro Ala Pro Ala Xaa Asp Ser Xaa Xaa Pro 
        115                 120                 125 


<210> 4593
<211> 193
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 4593
Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Xaa Pro Xaa Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Xaa Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Xaa Val Leu His Val Leu Gly Asp Arg Xaa Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Xaa His Ala Leu Ser Pro Pro His Ser Ser 
    130                 135                 140                 


Xaa Cys Glu Asn Arg Ala Pro Glu Ala Ser Lys Gly Gly Arg Ala Gln 
145                 150                 155                 160 


Asp Ser Arg Gly Pro Gly Pro Gly Xaa Glu Pro Ala Leu Cys Gly Ser 
                165                 170                 175     


Gly Pro Ser Ser Pro Gln Gln Ala Pro Pro Ala Val His Ser Gly Pro 
            180                 185                 190         


Cys 
    


<210> 4594
<211> 197
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<400> 4594
Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Xaa Pro Xaa Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Xaa Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Xaa Val Leu His Val Leu Gly Asp Arg Xaa Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Xaa His Ala Pro Leu Val Lys Xaa Glu Pro 
    130                 135                 140                 


Gln Arg Pro Val Lys Glu Glu Glu Pro Lys Ile Pro Gly Asp Leu Asp 
145                 150                 155                 160 


Gln Glu Pro Ser Leu Leu Tyr Ala Asp Leu Asp His Leu Ala Leu Ser 
                165                 170                 175     


Arg Pro Arg Arg Leu Ser Xaa Ala Asp Pro Ala Asp Ala Ser Xaa Ile 
            180                 185                 190         


Tyr Ala Val Val Val 
        195         


<210> 4595
<211> 217
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<400> 4595
Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Xaa Pro Xaa Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Xaa Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Xaa Val Leu His Val Leu Gly Asp Arg Xaa Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Xaa His Gly Ala Cys Pro Arg Asn Arg Phe 
    130                 135                 140                 


Asp His Ser Leu Asp Leu Leu Cys Pro Pro His Ile Ala Pro Leu Val 
145                 150                 155                 160 


Lys Xaa Glu Pro Gln Arg Pro Val Lys Glu Glu Glu Pro Lys Ile Pro 
                165                 170                 175     


Gly Asp Leu Asp Gln Glu Pro Ser Leu Leu Tyr Ala Asp Leu Asp His 
            180                 185                 190         


Leu Ala Leu Ser Arg Pro Arg Arg Leu Ser Xaa Ala Asp Pro Ala Asp 
        195                 200                 205             


Ala Ser Xaa Ile Tyr Ala Val Val Val 
    210                 215         


<210> 4596
<211> 217
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<400> 4596
Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Xaa Pro Xaa Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Xaa Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Xaa Val Leu His Val Leu Gly Asp Arg Xaa Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Xaa His Gly Ala Cys Pro Arg Asn Arg Leu 
    130                 135                 140                 


Asp His Ser Leu Asp Leu Leu Cys Pro Pro His Ile Ala Pro Leu Val 
145                 150                 155                 160 


Lys Xaa Glu Pro Gln Arg Pro Val Lys Glu Glu Glu Pro Lys Ile Pro 
                165                 170                 175     


Gly Asp Leu Asp Gln Glu Pro Ser Leu Leu Tyr Ala Asp Leu Asp His 
            180                 185                 190         


Leu Ala Leu Ser Arg Pro Arg Arg Leu Ser Xaa Ala Asp Pro Ala Asp 
        195                 200                 205             


Ala Ser Xaa Ile Tyr Ala Val Val Val 
    210                 215         


<210> 4597
<211> 237
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<400> 4597
Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Xaa Pro Xaa Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Xaa Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Xaa Val Leu His Val Leu Gly Asp Arg Xaa Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Xaa His Gly Ser Val Tyr Pro Gln Leu Leu 
    130                 135                 140                 


Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly 
145                 150                 155                 160 


Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Gly Pro 
                165                 170                 175     


Leu Pro Arg Phe Ala Leu Ser Pro Pro His Ser Ser Xaa Cys Glu Asn 
            180                 185                 190         


Arg Ala Pro Glu Ala Ser Lys Gly Gly Arg Ala Gln Asp Ser Arg Gly 
        195                 200                 205             


Pro Gly Pro Gly Xaa Glu Pro Ala Leu Cys Gly Ser Gly Pro Ser Ser 
    210                 215                 220                 


Pro Gln Gln Ala Pro Pro Ala Val His Ser Gly Pro Cys 
225                 230                 235         


<210> 4598
<211> 241
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<400> 4598
Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Xaa Pro Xaa Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Xaa Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Xaa Val Leu His Val Leu Gly Asp Arg Xaa Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Xaa His Gly Ser Val Tyr Pro Gln Leu Leu 
    130                 135                 140                 


Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly 
145                 150                 155                 160 


Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Gly Pro 
                165                 170                 175     


Leu Pro Arg Phe Ala Pro Leu Val Lys Xaa Glu Pro Gln Arg Pro Val 
            180                 185                 190         


Lys Glu Glu Glu Pro Lys Ile Pro Gly Asp Leu Asp Gln Glu Pro Ser 
        195                 200                 205             


Leu Leu Tyr Ala Asp Leu Asp His Leu Ala Leu Ser Arg Pro Arg Arg 
    210                 215                 220                 


Leu Ser Xaa Ala Asp Pro Ala Asp Ala Ser Xaa Ile Tyr Ala Val Val 
225                 230                 235                 240 


Val 
    


<210> 4599
<211> 237
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<400> 4599
Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Xaa Pro Xaa Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Xaa Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Xaa Val Leu His Val Leu Gly Asp Arg Xaa Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Xaa His Gly Ser Val Tyr Pro Gln Leu Leu 
    130                 135                 140                 


Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly 
145                 150                 155                 160 


Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Arg Pro 
                165                 170                 175     


Leu Pro Arg Phe Ala Leu Ser Pro Pro His Ser Ser Xaa Cys Glu Asn 
            180                 185                 190         


Arg Ala Pro Glu Ala Ser Lys Gly Gly Arg Ala Gln Asp Ser Arg Gly 
        195                 200                 205             


Pro Gly Pro Gly Xaa Glu Pro Ala Leu Cys Gly Ser Gly Pro Ser Ser 
    210                 215                 220                 


Pro Gln Gln Ala Pro Pro Ala Val His Ser Gly Pro Cys 
225                 230                 235         


<210> 4600
<211> 222
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<400> 4600
Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Xaa Pro Xaa Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Xaa Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Xaa Val Leu His Val Leu Gly Asp Arg Xaa Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Xaa His Gly Ser Val Tyr Pro Gln Leu Leu 
    130                 135                 140                 


Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly 
145                 150                 155                 160 


Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Arg Pro 
                165                 170                 175     


Leu Pro Arg Phe Ala Leu Ser Pro Pro His Ser Ser Xaa Cys Glu Asn 
            180                 185                 190         


Arg Ala Pro Glu Ala Ser Lys Gly Gly Arg Ala Gln Asp Ser Arg Gly 
        195                 200                 205             


Pro Gly Pro Gly Xaa Gly Lys Gly Met Gly Met Gly Arg Gly 
    210                 215                 220         


<210> 4601
<211> 241
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<400> 4601
Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Xaa Pro Xaa Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Xaa Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Xaa Val Leu His Val Leu Gly Asp Arg Xaa Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Xaa His Gly Ser Val Tyr Pro Gln Leu Leu 
    130                 135                 140                 


Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly 
145                 150                 155                 160 


Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Arg Pro 
                165                 170                 175     


Leu Pro Arg Phe Ala Pro Leu Val Lys Xaa Glu Pro Gln Arg Pro Val 
            180                 185                 190         


Lys Glu Glu Glu Pro Lys Ile Pro Gly Asp Leu Asp Gln Glu Pro Ser 
        195                 200                 205             


Leu Leu Tyr Ala Asp Leu Asp His Leu Ala Leu Ser Arg Pro Arg Arg 
    210                 215                 220                 


Leu Ser Xaa Ala Asp Pro Ala Asp Ala Ser Xaa Ile Tyr Ala Val Val 
225                 230                 235                 240 


Val 
    


<210> 4602
<211> 220
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<400> 4602
Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Xaa Pro Xaa Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Xaa Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Xaa Val Leu His Val Leu Gly Asp Arg Xaa Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Xaa His Gly Ser Val Tyr Pro Gln Leu Leu 
    130                 135                 140                 


Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly 
145                 150                 155                 160 


Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Arg Pro 
                165                 170                 175     


Leu Pro Arg Phe Ala Pro Leu Val Lys Xaa Glu Pro Gln Arg Pro Val 
            180                 185                 190         


Lys Glu Glu Glu Pro Lys Ile Pro Gly Asp Leu Asp Gln Glu Pro Val 
        195                 200                 205             


Arg Ala Trp Gly Trp Glu Gly Asp Ser Gln Asn Leu 
    210                 215                 220 


<210> 4603
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 4603
Met Lys Ala Lys Arg Ser His Gln Ala Val Ile Met Ser Xaa Ser Leu 
1               5                   10                  15      


Arg Val Ser Pro Ser Ile His Gly Tyr His Phe Asp Xaa Ala Ser Arg 
            20                  25                  30          


Lys Lys Ala Val Gly Asn Ile Phe Glu Asn Xaa Asp Gln Glu Ser Leu 
        35                  40                  45              


Glu Arg Leu Phe Arg Asn Ser Gly Asp Lys Lys Ala Glu Glu Arg Ala 
    50                  55                  60                  


Lys Ile Ile Phe Ala Ile Asp Gln Asp Val Glu Glu Lys Xaa Arg Ala 
65                  70                  75                  80  


Leu Met Ala Leu Lys Lys Arg Xaa Lys Asp Lys Leu Phe Gln Phe Leu 
                85                  90                  95      


Lys Leu Arg Lys Tyr Ser Ile Lys Val His 
            100                 105     


<210> 4604
<211> 97
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<400> 4604
Met Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp 
1               5                   10                  15      


His Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp 
            20                  25                  30          


Ile Asp Xaa His Xaa Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser 
        35                  40                  45              


Val Ser Tyr Asp Gln Ala Xaa Ser Leu Arg Ile Leu Asn Asn Gly His 
    50                  55                  60                  


Ala Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Ala Ser Leu 
65                  70                  75                  80  


Gly Ser Leu Glu His Gln Ile Trp Gly Phe Trp Glu Ser Cys Ala Ala 
                85                  90                  95      


Xaa 
    


<210> 4605
<211> 101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<400> 4605
Met Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp 
1               5                   10                  15      


His Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp 
            20                  25                  30          


Ile Asp Xaa His Xaa Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser 
        35                  40                  45              


Val Ser Tyr Asp Gln Ala Xaa Ser Leu Arg Ile Leu Asn Asn Gly His 
    50                  55                  60                  


Ala Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Glu Lys Gly 
65                  70                  75                  80  


Ile Ser Met Leu Arg Lys Lys Asp Val Lys Asn Ile His Ser Pro Asp 
                85                  90                  95      


Asn Ala Cys Glu Glu 
            100     


<210> 4606
<211> 260
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<400> 4606
Met Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp 
1               5                   10                  15      


His Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp 
            20                  25                  30          


Ile Asp Xaa His Xaa Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser 
        35                  40                  45              


Val Ser Tyr Asp Gln Ala Xaa Ser Leu Arg Ile Leu Asn Asn Gly His 
    50                  55                  60                  


Ala Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys 
65                  70                  75                  80  


Gly Gly Pro Leu Asp Gly Xaa Tyr Arg Leu Ile Gln Phe His Phe His 
                85                  90                  95      


Trp Gly Ser Leu Asp Gly Gln Gly Ser Glu His Xaa Val Asp Lys Lys 
            100                 105                 110         


Lys Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Xaa Lys Tyr Gly 
        115                 120                 125             


Asp Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly 
    130                 135                 140                 


Ile Phe Leu Lys Val Gly Ser Ala Lys Pro Gly Leu Gln Lys Val Val 
145                 150                 155                 160 


Asp Val Leu Asp Ser Ile Lys Xaa Lys Gly Lys Ser Ala Asp Phe Xaa 
                165                 170                 175     


Asn Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Xaa 
            180                 185                 190         


Tyr Pro Gly Ser Leu Xaa Xaa Pro Pro Leu Leu Glu Cys Val Xaa Trp 
        195                 200                 205             


Ile Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys 
    210                 215                 220                 


Phe Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met 
225                 230                 235                 240 


Val Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys 
                245                 250                 255     


Ala Ser Phe Lys 
            260 


<210> 4607
<211> 290
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<400> 4607
Met Ala Asp Leu Ser Phe Ile Glu Asp Xaa Val Ala Phe Pro Glu Lys 
1               5                   10                  15      


Glu Glu Asp Glu Glu Glu Glu Glu Glu Gly Val Glu Trp Gly Tyr Glu 
            20                  25                  30          


Glu Gly Val Glu Trp Gly Leu Val Phe Pro Asp Ala Asn Gly Glu Tyr 
        35                  40                  45              


Gln Ser Pro Ile Asn Leu Asn Ser Arg Glu Ala Arg Tyr Asp Pro Ser 
    50                  55                  60                  


Leu Leu Asp Val Arg Leu Ser Pro Asn Tyr Val Val Cys Arg Asp Cys 
65                  70                  75                  80  


Glu Val Xaa Asn Asp Gly His Xaa Ile Gln Val Ile Leu Lys Ser Lys 
                85                  90                  95      


Ser Val Leu Ser Gly Gly Pro Leu Pro Gln Gly His Glu Phe Glu Leu 
            100                 105                 110         


Tyr Glu Val Arg Phe His Trp Gly Arg Glu Asn Gln Arg Gly Ser Glu 
        115                 120                 125             


His Xaa Val Asn Phe Lys Ala Phe Pro Met Glu Leu His Leu Ile His 
    130                 135                 140                 


Trp Asn Ser Xaa Leu Phe Gly Ser Ile Asp Glu Ala Val Gly Lys Pro 
145                 150                 155                 160 


His Gly Ile Ala Ile Ile Ala Leu Phe Val Gln Ile Gly Lys Glu His 
                165                 170                 175     


Val Gly Leu Lys Ala Val Xaa Glu Ile Leu Gln Asp Ile Gln Tyr Lys 
            180                 185                 190         


Gly Lys Ser Lys Xaa Ile Pro Cys Phe Asn Pro Asn Xaa Leu Leu Pro 
        195                 200                 205             


Asp Pro Leu Leu Arg Asp Tyr Trp Val Tyr Glu Gly Ser Leu Xaa Ile 
    210                 215                 220                 


Pro Pro Cys Ser Glu Gly Val Xaa Trp Ile Leu Phe Arg Tyr Pro Leu 
225                 230                 235                 240 


Xaa Ile Ser Gln Leu Gln Ile Glu Glu Phe Arg Arg Leu Arg Xaa His 
                245                 250                 255     


Val Lys Gly Ala Glu Leu Val Glu Gly Cys Asp Gly Ile Leu Gly Asp 
            260                 265                 270         


Asn Phe Arg Pro Xaa Gln Pro Leu Ser Asp Arg Val Ile Arg Ala Ala 
        275                 280                 285             


Phe Gln 
    290 


<210> 4608
<211> 341
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<400> 4608
Met Pro Phe Pro Phe Gly Lys Ser His Lys Ser Pro Ala Asp Ile Val 
1               5                   10                  15      


Lys Asn Leu Lys Glu Ser Met Ala Val Leu Glu Lys Gln Asp Ile Ser 
            20                  25                  30          


Asp Lys Lys Ala Glu Lys Ala Xaa Glu Glu Val Ser Lys Asn Leu Val 
        35                  40                  45              


Ala Met Lys Glu Ile Leu Tyr Gly Xaa Asn Glu Lys Glu Pro Gln Xaa 
    50                  55                  60                  


Glu Ala Val Ala Gln Leu Ala Gln Glu Leu Tyr Asn Ser Gly Leu Leu 
65                  70                  75                  80  


Ser Xaa Leu Val Ala Asp Leu Gln Leu Ile Asp Phe Glu Gly Lys Lys 
                85                  90                  95      


Asp Val Ala Gln Ile Phe Asn Asn Ile Leu Arg Arg Gln Ile Gly Xaa 
            100                 105                 110         


Arg Xaa Pro Xaa Val Glu Tyr Ile Cys Xaa Gln Gln Asn Ile Leu Phe 
        115                 120                 125             


Met Leu Leu Lys Gly Tyr Glu Ser Pro Glu Ile Ala Leu Asn Cys Gly 
    130                 135                 140                 


Ile Met Leu Arg Glu Cys Ile Arg His Glu Pro Leu Ala Lys Ile Ile 
145                 150                 155                 160 


Leu Trp Ser Glu Gln Phe Tyr Asp Phe Phe Arg Tyr Val Glu Met Ser 
                165                 170                 175     


Xaa Phe Asp Ile Ala Ser Asp Ala Phe Ala Xaa Phe Lys Asp Leu Leu 
            180                 185                 190         


Xaa Arg His Lys Leu Leu Ser Ala Glu Phe Leu Glu Gln His Tyr Asp 
        195                 200                 205             


Arg Phe Phe Ser Glu Tyr Glu Lys Leu Leu His Ser Glu Asn Tyr Val 
    210                 215                 220                 


Xaa Lys Arg Gln Ser Leu Lys Leu Leu Gly Glu Leu Leu Leu Asp Arg 
225                 230                 235                 240 


His Asn Phe Xaa Ile Met Xaa Lys Tyr Ile Ser Lys Pro Glu Asn Leu 
                245                 250                 255     


Lys Leu Met Met Asn Leu Leu Arg Asp Lys Ser Arg Asn Ile Gln Phe 
            260                 265                 270         


Glu Ala Phe His Val Phe Lys Val Phe Val Ala Asn Pro Asn Lys Xaa 
        275                 280                 285             


Gln Pro Ile Leu Asp Ile Leu Leu Lys Asn Gln Ala Lys Leu Ile Glu 
    290                 295                 300                 


Phe Leu Ser Lys Phe Gln Asn Asp Arg Xaa Glu Asp Glu Gln Phe Asn 
305                 310                 315                 320 


Asp Glu Lys Xaa Tyr Leu Val Lys Gln Ile Arg Asp Leu Lys Arg Pro 
                325                 330                 335     


Ala Gln Gln Glu Ala 
            340     


<210> 4609
<211> 339
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<400> 4609
Met Pro Phe Pro Phe Gly Lys Ser His Lys Ser Pro Ala Asp Ile Val 
1               5                   10                  15      


Lys Asn Leu Lys Glu Ser Met Ala Val Leu Glu Lys Gln Asp Ile Ser 
            20                  25                  30          


Asp Lys Lys Ala Glu Lys Ala Xaa Glu Glu Val Ser Lys Asn Leu Val 
        35                  40                  45              


Ala Met Lys Glu Ile Leu Tyr Gly Xaa Asn Glu Lys Glu Pro Gln Xaa 
    50                  55                  60                  


Glu Ala Val Ala Gln Leu Ala Gln Glu Leu Tyr Asn Ser Gly Leu Leu 
65                  70                  75                  80  


Ser Xaa Leu Val Ala Asp Leu Gln Leu Ile Asp Phe Glu Gly Lys Lys 
                85                  90                  95      


Asp Val Ala Gln Ile Phe Asn Asn Ile Leu Arg Arg Gln Ile Gly Xaa 
            100                 105                 110         


Arg Xaa Pro Xaa Val Glu Tyr Ile Cys Xaa Gln Gln Asn Ile Leu Phe 
        115                 120                 125             


Met Leu Leu Lys Gly Tyr Glu Ser Pro Glu Ile Ala Leu Asn Cys Gly 
    130                 135                 140                 


Ile Met Leu Arg Glu Cys Ile Arg His Glu Pro Leu Ala Lys Ile Ile 
145                 150                 155                 160 


Leu Trp Ser Glu Gln Phe Tyr Asp Phe Phe Arg Tyr Val Glu Met Ser 
                165                 170                 175     


Xaa Phe Asp Ile Ala Ser Asp Ala Phe Ala Xaa Phe Lys Asp Leu Leu 
            180                 185                 190         


Xaa Arg His Lys Leu Leu Ser Ala Glu Phe Leu Val Leu Leu Ser Phe 
        195                 200                 205             


Phe Ser Glu Tyr Glu Lys Leu Leu His Ser Glu Asn Tyr Val Xaa Lys 
    210                 215                 220                 


Arg Gln Ser Leu Lys Leu Leu Gly Glu Leu Leu Leu Asp Arg His Asn 
225                 230                 235                 240 


Phe Xaa Ile Met Xaa Lys Tyr Ile Ser Lys Pro Glu Asn Leu Lys Leu 
                245                 250                 255     


Met Met Asn Leu Leu Arg Asp Lys Ser Arg Asn Ile Gln Phe Glu Ala 
            260                 265                 270         


Phe His Val Phe Lys Val Phe Val Ala Asn Pro Asn Lys Xaa Gln Pro 
        275                 280                 285             


Ile Leu Asp Ile Leu Leu Lys Asn Gln Ala Lys Leu Ile Glu Phe Leu 
    290                 295                 300                 


Ser Lys Phe Gln Asn Asp Arg Xaa Glu Asp Glu Gln Phe Asn Asp Glu 
305                 310                 315                 320 


Lys Xaa Tyr Leu Val Lys Gln Ile Arg Asp Leu Lys Arg Pro Ala Gln 
                325                 330                 335     


Gln Glu Ala 
            


<210> 4610
<211> 357
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<400> 4610
Met Ile Arg Ile Ala Ala Leu Asn Ala Ser Ser Xaa Ile Glu Asp Asp 
1               5                   10                  15      


His Glu Gly Ser Phe Lys Ser His Lys Xaa Gln Xaa Lys Glu Ala Gln 
            20                  25                  30          


Glu Ala Glu Ala Phe Ala Leu Tyr His Lys Ala Leu Asp Leu Gln Lys 
        35                  40                  45              


His Asp Arg Phe Glu Glu Ser Ala Lys Ala Tyr His Glu Leu Leu Glu 
    50                  55                  60                  


Ala Ser Leu Leu Arg Glu Ala Val Met Leu Asp Ser Xaa Asp Val Asn 
65                  70                  75                  80  


Leu Trp Tyr Lys Ile Gly His Val Ala Leu Arg Leu Ile Arg Ile Pro 
                85                  90                  95      


Leu Ala Arg His Ala Phe Glu Glu Gly Leu Arg Cys Asn Pro Asp His 
            100                 105                 110         


Trp Pro Cys Leu Asp Asn Leu Ile Xaa Val Leu Tyr Xaa Leu Ser Asp 
        115                 120                 125             


Tyr Xaa Xaa Cys Leu Tyr Phe Ile Cys Lys Ala Leu Glu Lys Asp Cys 
    130                 135                 140                 


Arg Tyr Ser Lys Gly Leu Val Leu Lys Glu Lys Ile Phe Glu Glu Gln 
145                 150                 155                 160 


Pro Cys Leu Arg Lys Asp Ser Leu Arg Met Phe Leu Lys Cys Asp Met 
                165                 170                 175     


Ser Ile His Asp Val Ser Val Ser Ala Ala Glu Xaa Gln Ala Ile Val 
            180                 185                 190         


Asp Glu Ala Leu Gly Leu Arg Lys Lys Arg Gln Ala Leu Ile Val Arg 
        195                 200                 205             


Glu Lys Glu Pro Asp Leu Lys Leu Val Gln Pro Ile Pro Phe Phe Xaa 
    210                 215                 220                 


Trp Lys Cys Leu Gly Glu Ser Leu Leu Ala Met Tyr Asn His Leu Xaa 
225                 230                 235                 240 


Xaa Cys Glu Pro Pro Arg Pro Ser Leu Gly Lys Arg Ile Asp Leu Ser 
                245                 250                 255     


Asp Tyr Gln Asp Pro Ser Gln Pro Leu Glu Ser Ser Met Val Val Xaa 
            260                 265                 270         


Pro Val Asn Val Ile Gln Pro Ser Xaa Val Ser Xaa Asn Pro Ala Val 
        275                 280                 285             


Ala Val Ala Glu Pro Val Val Ser Tyr Xaa Ser Val Ala Xaa Xaa Ser 
    290                 295                 300                 


Phe Pro Leu His Ser Pro Gly Leu Leu Glu Xaa Gly Ala Pro Val Gly 
305                 310                 315                 320 


Asp Ile Ser Gly Gly Asp Lys Ser Lys Lys Gly Val Lys Arg Lys Lys 
                325                 330                 335     


Ile Ser Glu Glu Ser Gly Glu Xaa Ala Lys Arg Arg Ser Ala Arg Val 
            340                 345                 350         


Arg Asn Xaa Lys Cys 
        355         


<210> 4611
<211> 361
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<400> 4611
Met Ile Arg Ile Ala Ala Leu Asn Ala Ser Ser Xaa Ile Glu Asp Asp 
1               5                   10                  15      


His Glu Gly Ser Phe Lys Ser His Lys Xaa Gln Xaa Lys Glu Ala Gln 
            20                  25                  30          


Glu Ala Glu Ala Phe Ala Leu Tyr His Lys Ala Leu Asp Leu Gln Lys 
        35                  40                  45              


His Asp Arg Phe Glu Glu Ser Ala Lys Ala Tyr His Glu Leu Leu Glu 
    50                  55                  60                  


Ala Ser Leu Leu Arg Glu Ala Val Met Leu Asp Ser Xaa Asp Val Asn 
65                  70                  75                  80  


Leu Trp Tyr Lys Ile Gly His Val Ala Leu Arg Leu Ile Arg Ile Pro 
                85                  90                  95      


Leu Ala Arg His Ala Phe Glu Glu Gly Leu Arg Cys Asn Pro Asp His 
            100                 105                 110         


Trp Pro Cys Leu Asp Asn Leu Ile Xaa Val Leu Tyr Xaa Leu Ser Asp 
        115                 120                 125             


Tyr Xaa Xaa Cys Leu Tyr Phe Ile Cys Lys Ala Leu Glu Lys Asp Cys 
    130                 135                 140                 


Arg Tyr Ser Lys Gly Leu Val Leu Lys Glu Lys Ile Phe Glu Glu Gln 
145                 150                 155                 160 


Pro Cys Leu Arg Lys Asp Ser Leu Arg Met Phe Leu Lys Cys Asp Met 
                165                 170                 175     


Ser Ile His Asp Val Ser Val Ser Ala Ala Glu Xaa Gln Ala Ile Val 
            180                 185                 190         


Asp Glu Ala Leu Gly Leu Arg Lys Lys Arg Gln Ala Leu Ile Val Arg 
        195                 200                 205             


Glu Lys Glu Pro Asp Leu Lys Leu Val Gln Pro Ile Pro Phe Phe Xaa 
    210                 215                 220                 


Trp Lys Cys Leu Gly Glu Ser Leu Leu Ala Met Tyr Asn His Leu Xaa 
225                 230                 235                 240 


Xaa Cys Glu Pro Pro Arg Pro Ser Leu Gly Lys Arg Ile Asp Leu Ser 
                245                 250                 255     


Asp Tyr Gln Asp Pro Ser Gln Pro Leu Glu Ser Ser Met Val Val Xaa 
            260                 265                 270         


Pro Val Asn Val Ile Gln Pro Ser Xaa Val Ser Xaa Asn Pro Ala Val 
        275                 280                 285             


Ala Val Ala Glu Pro Val Val Ser Tyr Xaa Ser Val Ala Xaa Xaa Ser 
    290                 295                 300                 


Phe Pro Leu His Ser Pro Gly Leu Leu Glu Xaa Gly Ala Pro Val Gly 
305                 310                 315                 320 


Asp Ile Ser Gly Gly Asp Lys Ser Lys Lys Gly Val Lys Arg Lys Lys 
                325                 330                 335     


Ile Ser Glu Glu Ser Gly Glu Xaa Ala Lys Arg Arg Ser Ala Arg Val 
            340                 345                 350         


Arg Asn Xaa Lys Cys Lys Lys Glu Glu 
        355                 360     


<210> 4612
<211> 2220
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1123)..(1123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1224)..(1224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1346)..(1346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1353)..(1353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1379)..(1379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1397)..(1397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1422)..(1422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1430)..(1430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1443)..(1443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1460)..(1460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1474)..(1474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1476)..(1476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1509)..(1509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1538)..(1538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1578)..(1578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1632)..(1632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1656)..(1656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1663)..(1663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1687)..(1688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1758)..(1758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1763)..(1763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1767)..(1767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1776)..(1776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1795)..(1795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1811)..(1811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1814)..(1814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1826)..(1828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1830)..(1830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1853)..(1853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1858)..(1858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1888)..(1888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1924)..(1924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1926)..(1927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1942)..(1942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1946)..(1946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1964)..(1964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1974)..(1975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1978)..(1978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1987)..(1987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2005)..(2005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2025)..(2025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2043)..(2043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2060)..(2060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2065)..(2065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2089)..(2089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2097)..(2097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2142)..(2142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2149)..(2149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2151)..(2151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2154)..(2154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2156)..(2156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2168)..(2168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2200)..(2200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2211)..(2211)
<223> Selenocysteine

<400> 4612
Met Ile Arg Ile Ala Ala Leu Asn Ala Ser Ser Xaa Ile Glu Asp Asp 
1               5                   10                  15      


His Glu Gly Ser Phe Lys Ser His Lys Xaa Gln Xaa Lys Glu Ala Gln 
            20                  25                  30          


Glu Ala Glu Ala Phe Ala Leu Tyr His Lys Ala Leu Asp Leu Gln Lys 
        35                  40                  45              


His Asp Arg Phe Glu Glu Ser Ala Lys Ala Tyr His Glu Leu Leu Glu 
    50                  55                  60                  


Ala Ser Leu Leu Arg Glu Ala Val Ser Ser Gly Asp Glu Lys Glu Gly 
65                  70                  75                  80  


Leu Lys His Pro Gly Leu Ile Leu Lys Tyr Ser Xaa Tyr Lys Asn Leu 
                85                  90                  95      


Ala Gln Leu Ala Ala Gln Arg Glu Asp Leu Glu Xaa Ala Met Glu Phe 
            100                 105                 110         


Tyr Leu Glu Ala Val Met Leu Asp Ser Xaa Asp Val Asn Leu Trp Tyr 
        115                 120                 125             


Lys Ile Gly His Val Ala Leu Arg Leu Ile Arg Ile Pro Leu Ala Arg 
    130                 135                 140                 


His Ala Phe Glu Glu Gly Leu Arg Cys Asn Pro Asp His Trp Pro Cys 
145                 150                 155                 160 


Leu Asp Asn Leu Ile Xaa Val Leu Tyr Xaa Leu Ser Asp Tyr Xaa Xaa 
                165                 170                 175     


Cys Leu Tyr Phe Ile Cys Lys Ala Leu Glu Lys Asp Cys Arg Tyr Ser 
            180                 185                 190         


Lys Gly Leu Val Leu Lys Glu Lys Ile Phe Glu Glu Gln Pro Cys Leu 
        195                 200                 205             


Arg Lys Asp Ser Leu Arg Met Phe Leu Lys Cys Asp Met Ser Ile His 
    210                 215                 220                 


Asp Val Ser Val Ser Ala Ala Glu Xaa Gln Ala Ile Val Asp Glu Ala 
225                 230                 235                 240 


Leu Gly Leu Arg Lys Lys Arg Gln Ala Leu Ile Val Arg Glu Lys Glu 
                245                 250                 255     


Pro Asp Leu Lys Leu Val Gln Pro Ile Pro Phe Phe Xaa Trp Lys Cys 
            260                 265                 270         


Leu Gly Glu Ser Leu Leu Ala Met Tyr Asn His Leu Xaa Xaa Cys Glu 
        275                 280                 285             


Pro Pro Arg Pro Ser Leu Gly Lys Arg Ile Asp Leu Ser Asp Tyr Gln 
    290                 295                 300                 


Asp Pro Ser Gln Pro Leu Glu Ser Ser Met Val Val Xaa Pro Val Asn 
305                 310                 315                 320 


Val Ile Gln Pro Ser Xaa Val Ser Xaa Asn Pro Ala Val Ala Val Ala 
                325                 330                 335     


Glu Pro Val Val Ser Tyr Xaa Ser Val Ala Xaa Xaa Ser Phe Pro Leu 
            340                 345                 350         


His Ser Pro Gly Leu Leu Glu Xaa Gly Ala Pro Val Gly Asp Ile Ser 
        355                 360                 365             


Gly Gly Asp Lys Ser Lys Lys Gly Val Lys Arg Lys Lys Ile Ser Glu 
    370                 375                 380                 


Glu Ser Gly Glu Xaa Ala Lys Arg Arg Ser Ala Arg Val Arg Asn Xaa 
385                 390                 395                 400 


Lys Cys Lys Lys Glu Glu Lys Val Asp Phe Gln Glu Leu Leu Met Lys 
                405                 410                 415     


Phe Leu Pro Ser Arg Leu Arg Lys Leu Asp Pro Glu Glu Glu Asp Asp 
            420                 425                 430         


Ser Phe Asn Asn Tyr Glu Val Gln Ser Glu Ala Lys Leu Glu Ser Phe 
        435                 440                 445             


Pro Ser Ile Gly Pro Gln Arg Leu Ser Phe Asp Ser Ala Xaa Phe Met 
    450                 455                 460                 


Glu Ser Glu Lys Gln Asp Val His Glu Phe Leu Leu Glu Asn Leu Xaa 
465                 470                 475                 480 


Asn Gly Gly Ile Leu Glu Leu Met Met Arg Tyr Leu Lys Ala Met Gly 
                485                 490                 495     


His Lys Phe Leu Val Arg Trp Pro Pro Gly Leu Ala Glu Val Val Leu 
            500                 505                 510         


Ser Val Tyr His Ser Trp Arg Arg His Ser Xaa Ser Leu Pro Asn Pro 
        515                 520                 525             


Leu Leu Arg Asp Cys Ser Asn Lys His Ile Lys Asp Met Met Leu Met 
    530                 535                 540                 


Ser Leu Ser Cys Met Glu Leu Gln Leu Asp Gln Trp Leu Leu Xaa Lys 
545                 550                 555                 560 


Gly Arg Ser Ser Ala Val Ser Pro Arg Asn Cys Pro Ala Gly Met Val 
                565                 570                 575     


Asn Gly Arg Phe Gly Pro Asp Phe Pro Gly Xaa His Cys Leu Gly Asp 
            580                 585                 590         


Leu Leu Gln Leu Ser Phe Ala Ser Ser Gln Arg Asp Leu Phe Glu Asp 
        595                 600                 605             


Gly Trp Leu Glu Phe Val Val Arg Val Tyr Trp Leu Lys Ala Arg Phe 
    610                 615                 620                 


Leu Ala Leu Gln Gly Asp Met Glu Gln Ala Leu Glu Asn Tyr Asp Ile 
625                 630                 635                 640 


Cys Xaa Glu Met Leu Gln Ser Ser Xaa Ala Ile Gln Val Glu Ala Gly 
                645                 650                 655     


Ala Glu Arg Arg Asp Ile Val Ile Arg Leu Pro Asn Leu His Asn Asp 
            660                 665                 670         


Ser Val Val Ser Leu Glu Glu Ile Asp Lys Asn Leu Lys Ser Leu Glu 
        675                 680                 685             


Arg Cys Gln Ser Leu Glu Glu Ile Gln Arg Leu Tyr Glu Ala Gly Asp 
    690                 695                 700                 


Tyr Lys Ala Val Val His Leu Leu Arg Pro Xaa Leu Cys Xaa Ser Gly 
705                 710                 715                 720 


Phe Asp Arg Ala Lys His Leu Glu Phe Met Xaa Ser Ile Pro Glu Arg 
                725                 730                 735     


Pro Ala Gln Leu Leu Leu Leu Gln Asp Ser Leu Leu Arg Leu Lys Asp 
            740                 745                 750         


Tyr Arg Gln Cys Phe Glu Cys Ser Asp Val Ala Leu Asn Glu Ala Val 
        755                 760                 765             


Gln Gln Met Val Asn Ser Gly Glu Ala Ala Ala Lys Glu Glu Trp Val 
    770                 775                 780                 


Ala Xaa Val Xaa Gln Leu Leu Met Gly Ile Glu Gln Ala Leu Ser Ala 
785                 790                 795                 800 


Asp Ser Ser Gly Ser Ile Leu Lys Val Ser Ser Ser Xaa Xaa Gly Leu 
                805                 810                 815     


Val Arg Leu Xaa Asn Asn Leu Ile Gln Val Ile Asp Cys Ser Met Ala 
            820                 825                 830         


Val Gln Glu Glu Ala Lys Glu Pro His Val Ser Ser Val Leu Pro Trp 
        835                 840                 845             


Ile Ile Leu His Arg Ile Ile Trp Gln Glu Glu Asp Xaa Phe His Ser 
    850                 855                 860                 


Leu Cys His Gln Gln Gln Leu Gln Asn Pro Ala Glu Glu Gly Met Ser 
865                 870                 875                 880 


Glu Xaa Pro Met Leu Pro Ser Ser Leu Met Leu Leu Asn Xaa Ala His 
                885                 890                 895     


Glu Tyr Leu Gly Arg Arg Ser Trp Cys Cys Asn Ser Asp Gly Ala Leu 
            900                 905                 910         


Leu Arg Phe Tyr Val Arg Val Leu Gln Lys Glu Leu Ala Ala Ser Xaa 
        915                 920                 925             


Ser Glu Asp Xaa His Pro Tyr Lys Glu Glu Leu Glu Xaa Ala Leu Glu 
    930                 935                 940                 


Gln Cys Phe Tyr Cys Leu Tyr Ser Phe Pro Ser Lys Lys Ser Lys Ala 
945                 950                 955                 960 


Arg Tyr Leu Glu Glu His Ser Ala Gln Gln Val Asp Leu Ile Trp Glu 
                965                 970                 975     


Asp Ala Leu Phe Met Phe Glu Tyr Phe Lys Pro Lys Xaa Leu Pro Glu 
            980                 985                 990         


Phe Asp Ser Tyr Lys Xaa Ser Xaa  Val Ser Ala Asp Leu  Ala Asn Leu 
        995                 1000                 1005             


Leu Lys  Arg Ile Ala Xaa Ile  Val Pro Arg Xaa Glu  Arg Pro Ala 
    1010                 1015                 1020             


Leu Ser  Leu Asp Lys Val Ser  Ala Tyr Ile Glu Gly  Xaa Ser Xaa 
    1025                 1030                 1035             


Glu Val  Pro Cys Leu Pro Glu  Gly Ala Asp Pro Ser  Pro Pro Val 
    1040                 1045                 1050             


Val Asn  Glu Leu Tyr Tyr Leu  Leu Ala Asp Tyr His  Phe Lys Asn 
    1055                 1060                 1065             


Lys Glu  Gln Ser Lys Ala Ile  Lys Phe Tyr Met His  Asp Ile Cys 
    1070                 1075                 1080             


Ile Cys  Pro Asn Arg Phe Asp  Ser Trp Ala Gly Met  Ala Leu Ala 
    1085                 1090                 1095             


Arg Ala  Ser Arg Ile Gln Asp  Lys Leu Asn Ser Asn  Glu Leu Lys 
    1100                 1105                 1110             


Ser Asp  Gly Pro Ile Trp Lys  His Ala Xaa Pro Val  Leu Asn Cys 
    1115                 1120                 1125             


Phe Arg  Arg Ala Leu Glu Ile  Asp Ser Ser Asn Leu  Ser Leu Trp 
    1130                 1135                 1140             


Ile Glu  Tyr Gly Xaa Met Ser  Tyr Ala Leu His Ser  Phe Ala Ser 
    1145                 1150                 1155             


Arg Gln  Leu Lys Gln Trp Arg  Gly Glu Leu Pro Pro  Glu Leu Val 
    1160                 1165                 1170             


Gln Gln  Met Glu Gly Arg Arg  Asp Ser Met Leu Glu  Xaa Ala Lys 
    1175                 1180                 1185             


His Cys  Phe Xaa Ser Ala Ala  Arg Cys Glu Gly Asp  Gly Asp Glu 
    1190                 1195                 1200             


Glu Glu  Trp Leu Ile His Tyr  Met Leu Gly Lys Val  Ala Glu Lys 
    1205                 1210                 1215             


Gln Gln  Gln Pro Pro Xaa Val  Tyr Leu Leu His Tyr  Arg Gln Ala 
    1220                 1225                 1230             


Gly His  Tyr Leu His Glu Glu  Ala Ala Arg Tyr Pro  Lys Lys Ile 
    1235                 1240                 1245             


His Tyr  His Asn Pro Pro Glu  Leu Ala Met Glu Ala  Leu Glu Val 
    1250                 1255                 1260             


Tyr Phe  Arg Leu His Ala Ser  Ile Leu Lys Leu Leu  Gly Lys Pro 
    1265                 1270                 1275             


Asp Ser  Gly Val Gly Ala Glu  Val Leu Val Asn Phe  Met Lys Glu 
    1280                 1285                 1290             


Ala Ala  Glu Gly Pro Phe Ala  Arg Gly Glu Glu Lys  Asn Xaa Pro 
    1295                 1300                 1305             


Lys Ala  Ser Glu Lys Glu Lys  Ala Cys Leu Val Asp  Glu Asp Ser 
    1310                 1315                 1320             


His Ser  Ser Ala Gly Xaa Leu  Pro Gly Pro Gly Ala  Ser Leu Pro 
    1325                 1330                 1335             


Ser Ser  Ser Gly Pro Gly Leu  Xaa Ser Pro Pro Tyr  Xaa Ala Xaa 
    1340                 1345                 1350             


Pro Ile  Asp His Asp Tyr Val  Lys Cys Lys Lys Pro  His Gln Gln 
    1355                 1360                 1365             


Ala Xaa  Pro Asp Asp Arg Ser  Gln Asp Ser Xaa Ala  Val Ala Leu 
    1370                 1375                 1380             


Ser Asp  Ser Ser Ser Xaa Gln  Asp Phe Phe Asn Glu  Pro Xaa Ser 
    1385                 1390                 1395             


Leu Leu  Glu Gly Ser Arg Lys  Ser Tyr Xaa Glu Lys  Arg Leu Pro 
    1400                 1405                 1410             


Ile Leu  Ser Ser Gln Ala Gly  Ala Xaa Gly Lys Asp  Leu Gln Gly 
    1415                 1420                 1425             


Ala Xaa  Glu Glu Arg Gly Lys  Asn Glu Glu Ser Leu  Glu Ser Xaa 
    1430                 1435                 1440             


Glu Gly  Phe Arg Ala Ala Glu  Gln Gly Val Gln Lys  Pro Ala Ala 
    1445                 1450                 1455             


Glu Xaa  Pro Ala Ser Ala Cys  Ile Pro Gly Lys Pro  Ser Ala Ser 
    1460                 1465                 1470             


Xaa Pro  Xaa Leu Trp Asp Gly  Lys Lys Arg Gly Asp  Leu Pro Gly 
    1475                 1480                 1485             


Glu Pro  Val Ala Phe Pro Gln  Gly Leu Pro Ala Gly  Ala Glu Glu 
    1490                 1495                 1500             


Gln Arg  Gln Phe Leu Xaa Glu  Gln Cys Ile Ala Ser  Phe Arg Leu 
    1505                 1510                 1515             


Cys Leu  Ser Arg Phe Pro Gln  His Tyr Lys Ser Leu  Tyr Arg Leu 
    1520                 1525                 1530             


Ala Phe  Leu Tyr Xaa Tyr Ser  Lys Xaa His Arg Asn  Leu Gln Trp 
    1535                 1540                 1545             


Ala Arg  Asp Val Leu Leu Gly  Ser Ser Ile Pro Trp  Gln Gln Leu 
    1550                 1555                 1560             


Gln His  Met Pro Ala Gln Gly  Leu Phe Cys Glu Arg  Asn Lys Xaa 
    1565                 1570                 1575             


Asn Phe  Phe Asn Gly Ile Trp  Arg Ile Pro Val Asp  Glu Ile Asp 
    1580                 1585                 1590             


Arg Pro  Gly Ser Phe Ala Trp  His Met Asn Arg Ser  Ile Val Leu 
    1595                 1600                 1605             


Leu Leu  Lys Val Leu Ala Gln  Leu Arg Asp His Ser  Xaa Leu Leu 
    1610                 1615                 1620             


Lys Val  Ser Ser Met Leu Gln  Arg Xaa Pro Asp Gln  Gly Lys Lys 
    1625                 1630                 1635             


Tyr Leu  Arg Asp Ala Asp Arg  Gln Val Leu Ala Gln  Arg Ala Phe 
    1640                 1645                 1650             


Ile Leu  Xaa Val Lys Val Leu  Glu Asp Xaa Leu Ser  Glu Leu Ala 
    1655                 1660                 1665             


Glu Gly  Ser Glu Arg Pro Gly  Pro Lys Val Cys Gly  Leu Pro Gly 
    1670                 1675                 1680             


Ala Arg  Met Xaa Xaa Asp Val  Ser His Lys Ala Ser  Pro Glu Asp 
    1685                 1690                 1695             


Gly Gln  Glu Gly Leu Pro Gln  Pro Lys Lys Pro Pro  Leu Ala Asp 
    1700                 1705                 1710             


Gly Ser  Gly Pro Gly Pro Glu  Pro Gly Gly Lys Val  Gly Leu Leu 
    1715                 1720                 1725             


Asn His  Arg Pro Val Ala Met  Asp Ala Gly Asp Ser  Ala Asp Gln 
    1730                 1735                 1740             


Ser Gly  Glu Arg Lys Asp Lys  Glu Ser Pro Arg Ala  Gly Pro Xaa 
    1745                 1750                 1755             


Glu Pro  Met Asp Xaa Ser Glu  Ala Xaa Val Cys His  Ser Asp Leu 
    1760                 1765                 1770             


Glu Arg  Xaa Pro Pro Leu Leu  Pro Gly Arg Pro Ala  Arg Asp Arg 
    1775                 1780                 1785             


Gly Pro  Glu Ser Arg Pro Xaa  Glu Leu Ser Leu Glu  Glu Leu Ser 
    1790                 1795                 1800             


Ile Ser  Ala Arg Gln Gln Pro  Xaa Pro Leu Xaa Pro  Ala Gln Pro 
    1805                 1810                 1815             


Ala Pro  Ala Pro Ala Pro Ala  Xaa Xaa Xaa Gly Xaa  Arg Ala Gly 
    1820                 1825                 1830             


Gly His  Pro Glu Glu Pro Leu  Ser Arg Leu Ser Arg  Lys Arg Lys 
    1835                 1840                 1845             


Leu Leu  Glu Asp Xaa Glu Ser  Gly Lys Xaa Leu Leu  Leu Asp Ala 
    1850                 1855                 1860             


Tyr Arg  Val Trp Gln Gln Gly  Gln Lys Gly Val Ala  Tyr Asp Leu 
    1865                 1870                 1875             


Gly Arg  Val Glu Arg Ile Met  Ser Glu Xaa Tyr Met  Leu Ile Lys 
    1880                 1885                 1890             


Gln Val  Asp Glu Glu Ala Ala  Leu Glu Gln Ala Val  Lys Phe Cys 
    1895                 1900                 1905             


Gln Val  His Leu Gly Ala Ala  Ala Gln Arg Gln Ala  Ser Gly Asp 
    1910                 1915                 1920             


Xaa Pro  Xaa Xaa Pro Lys His  Pro Lys Asp Ser Arg  Glu Asn Phe 
    1925                 1930                 1935             


Phe Pro  Val Xaa Val Val Pro  Xaa Ala Pro Asp Pro  Val Pro Ala 
    1940                 1945                 1950             


Asp Ser  Val Gln Arg Pro Ser  Asp Ala His Xaa Lys  Pro Arg Pro 
    1955                 1960                 1965             


Ala Leu  Ala Ala Ala Xaa Xaa  Ile Ile Xaa Cys Pro  Pro Ser Ala 
    1970                 1975                 1980             


Ser Ala  Ser Xaa Leu Asp Gln  Ser Lys Asp Pro Gly  Pro Pro Arg 
    1985                 1990                 1995             


Pro His  Arg Pro Glu Ala Xaa  Pro Ser Met Ala Ser  Leu Gly Pro 
    2000                 2005                 2010             


Glu Gly  Glu Glu Leu Ala Arg  Val Ala Glu Gly Xaa  Ser Phe Pro 
    2015                 2020                 2025             


Pro Gln  Glu Pro Arg His Ser  Pro Gln Val Lys Met  Ala Pro Xaa 
    2030                 2035                 2040             


Ser Ser  Pro Ala Glu Pro His  Cys Trp Pro Ala Glu  Ala Ala Leu 
    2045                 2050                 2055             


Gly Xaa  Gly Ala Glu Pro Xaa  Cys Ser Gln Glu Gly  Lys Leu Arg 
    2060                 2065                 2070             


Pro Glu  Pro Arg Arg Asp Gly  Glu Ala Gln Glu Ala  Ala Ser Glu 
    2075                 2080                 2085             


Xaa Gln  Pro Leu Ser Ser Pro  Pro Xaa Ala Ala Ser  Ser Lys Ala 
    2090                 2095                 2100             


Pro Ser  Ser Gly Ser Ala Gln  Pro Pro Glu Gly His  Pro Gly Lys 
    2105                 2110                 2115             


Pro Glu  Pro Ser Arg Ala Lys  Ser Arg Pro Leu Pro  Asn Met Pro 
    2120                 2125                 2130             


Lys Leu  Val Ile Pro Ser Ala  Ala Xaa Lys Phe Pro  Pro Glu Ile 
    2135                 2140                 2145             


Xaa Val  Xaa Pro Pro Xaa Pro  Xaa Leu Leu Ser Pro  Lys Gly Ser 
    2150                 2155                 2160             


Ile Ser  Glu Glu Xaa Lys Gln  Lys Leu Lys Ser Ala  Ile Leu Ser 
    2165                 2170                 2175             


Ala Gln  Ser Ala Ala Asn Val  Arg Lys Glu Ser Leu  Cys Gln Pro 
    2180                 2185                 2190             


Ala Leu  Glu Val Leu Glu Xaa  Ser Ser Gln Glu Ser  Ser Leu Glu 
    2195                 2200                 2205             


Ser Glu  Xaa Asp Glu Asp Asp  Asp Tyr Met Asp Ile  
    2210                 2215                 2220 


<210> 4613
<211> 2141
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1300)..(1300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1343)..(1343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1364)..(1364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1395)..(1395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1397)..(1397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1430)..(1430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1459)..(1459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1463)..(1463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1499)..(1499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1553)..(1553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1577)..(1577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1584)..(1584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1608)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1679)..(1679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1684)..(1684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1688)..(1688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1697)..(1697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1716)..(1716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1732)..(1732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1735)..(1735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1747)..(1749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1751)..(1751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1774)..(1774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1779)..(1779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1809)..(1809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1845)..(1845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1847)..(1848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1863)..(1863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1867)..(1867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1885)..(1885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1895)..(1896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1899)..(1899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1908)..(1908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1926)..(1926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1946)..(1946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1964)..(1964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1981)..(1981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1986)..(1986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2010)..(2010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2018)..(2018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2063)..(2063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2070)..(2070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2072)..(2072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2075)..(2075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2077)..(2077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2089)..(2089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2121)..(2121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2132)..(2132)
<223> Selenocysteine

<400> 4613
Met Ile Arg Ile Ala Ala Leu Asn Ala Ser Ser Xaa Ile Glu Asp Asp 
1               5                   10                  15      


His Glu Gly Ser Phe Lys Ser His Lys Xaa Gln Xaa Lys Glu Ala Gln 
            20                  25                  30          


Glu Ala Glu Ala Phe Ala Leu Tyr His Lys Ala Leu Asp Leu Gln Lys 
        35                  40                  45              


His Asp Arg Phe Glu Glu Ser Ala Lys Ala Tyr His Glu Leu Leu Glu 
    50                  55                  60                  


Ala Ser Leu Leu Arg Glu Ala Val Ser Ser Gly Asp Glu Lys Glu Gly 
65                  70                  75                  80  


Leu Lys His Pro Gly Leu Ile Leu Lys Tyr Ser Xaa Tyr Lys Asn Leu 
                85                  90                  95      


Ala Gln Leu Ala Ala Gln Arg Glu Asp Leu Glu Xaa Ala Met Glu Phe 
            100                 105                 110         


Tyr Leu Glu Ala Val Met Leu Asp Ser Xaa Asp Val Asn Leu Trp Tyr 
        115                 120                 125             


Lys Ile Gly His Val Ala Leu Arg Leu Ile Arg Ile Pro Leu Ala Arg 
    130                 135                 140                 


His Ala Phe Glu Glu Gly Leu Arg Cys Asn Pro Asp His Trp Pro Cys 
145                 150                 155                 160 


Leu Asp Asn Leu Ile Xaa Val Leu Tyr Xaa Leu Ser Asp Tyr Xaa Xaa 
                165                 170                 175     


Cys Leu Tyr Phe Ile Cys Lys Ala Leu Glu Lys Asp Cys Arg Tyr Ser 
            180                 185                 190         


Lys Gly Leu Val Leu Lys Glu Lys Ile Phe Glu Glu Gln Pro Cys Leu 
        195                 200                 205             


Arg Lys Asp Ser Leu Arg Met Phe Leu Lys Cys Trp Lys Cys Leu Gly 
    210                 215                 220                 


Glu Ser Leu Leu Ala Met Tyr Asn His Leu Xaa Xaa Cys Glu Pro Pro 
225                 230                 235                 240 


Arg Pro Ser Leu Gly Lys Arg Ile Asp Leu Ser Asp Tyr Gln Asp Pro 
                245                 250                 255     


Ser Gln Pro Leu Glu Ser Ser Met Val Val Xaa Pro Val Asn Val Ile 
            260                 265                 270         


Gln Pro Ser Xaa Val Ser Xaa Asn Pro Ala Val Ala Val Ala Glu Pro 
        275                 280                 285             


Val Val Ser Tyr Xaa Ser Val Ala Xaa Xaa Ser Phe Pro Leu His Ser 
    290                 295                 300                 


Pro Gly Leu Leu Glu Xaa Gly Ala Pro Val Gly Asp Ile Ser Gly Gly 
305                 310                 315                 320 


Asp Lys Ser Lys Lys Gly Val Lys Arg Lys Lys Ile Ser Glu Glu Ser 
                325                 330                 335     


Gly Glu Xaa Ala Lys Arg Arg Ser Ala Arg Val Arg Asn Xaa Lys Cys 
            340                 345                 350         


Lys Lys Glu Glu Lys Val Asp Phe Gln Glu Leu Leu Met Lys Phe Leu 
        355                 360                 365             


Pro Ser Arg Leu Arg Lys Leu Asp Pro Glu Glu Glu Asp Asp Ser Phe 
    370                 375                 380                 


Asn Asn Tyr Glu Val Gln Ser Glu Ala Lys Leu Glu Ser Phe Pro Ser 
385                 390                 395                 400 


Ile Gly Pro Gln Arg Leu Ser Phe Asp Ser Ala Xaa Phe Met Glu Ser 
                405                 410                 415     


Glu Lys Gln Asp Val His Glu Phe Leu Leu Glu Asn Leu Xaa Asn Gly 
            420                 425                 430         


Gly Ile Leu Glu Leu Met Met Arg Tyr Leu Lys Ala Met Gly His Lys 
        435                 440                 445             


Phe Leu Val Arg Trp Pro Pro Gly Leu Ala Glu Val Val Leu Ser Val 
    450                 455                 460                 


Tyr His Ser Trp Arg Arg His Ser Xaa Ser Leu Pro Asn Pro Leu Leu 
465                 470                 475                 480 


Arg Asp Cys Ser Asn Lys His Ile Lys Asp Met Met Leu Met Ser Leu 
                485                 490                 495     


Ser Cys Met Glu Leu Gln Leu Asp Gln Trp Leu Leu Xaa Lys Gly Arg 
            500                 505                 510         


Ser Ser Ala Val Ser Pro Arg Asn Cys Pro Ala Gly Met Val Asn Gly 
        515                 520                 525             


Arg Phe Gly Pro Asp Phe Pro Gly Xaa His Cys Leu Gly Asp Leu Leu 
    530                 535                 540                 


Gln Leu Ser Phe Ala Ser Ser Gln Arg Asp Leu Phe Glu Asp Gly Trp 
545                 550                 555                 560 


Leu Glu Phe Val Val Arg Val Tyr Trp Leu Lys Ala Arg Phe Leu Ala 
                565                 570                 575     


Leu Gln Gly Asp Met Glu Gln Ala Leu Glu Asn Tyr Asp Ile Cys Xaa 
            580                 585                 590         


Glu Met Leu Gln Ser Ser Xaa Ala Ile Gln Val Glu Ala Gly Ala Glu 
        595                 600                 605             


Arg Arg Asp Ile Val Ile Arg Leu Pro Asn Leu His Asn Asp Ser Val 
    610                 615                 620                 


Val Ser Leu Glu Glu Ile Asp Lys Asn Leu Lys Ser Leu Glu Arg Cys 
625                 630                 635                 640 


Gln Ser Leu Glu Glu Ile Gln Arg Leu Tyr Glu Ala Gly Asp Tyr Lys 
                645                 650                 655     


Ala Val Val His Leu Leu Arg Pro Xaa Leu Cys Xaa Ser Gly Phe Asp 
            660                 665                 670         


Arg Ala Lys His Leu Glu Phe Met Xaa Ser Ile Pro Glu Arg Pro Ala 
        675                 680                 685             


Gln Leu Leu Leu Leu Gln Asp Ser Leu Leu Arg Leu Lys Asp Tyr Arg 
    690                 695                 700                 


Gln Cys Phe Glu Cys Ser Asp Val Ala Leu Asn Glu Ala Val Gln Gln 
705                 710                 715                 720 


Met Val Asn Ser Gly Glu Ala Ala Ala Lys Glu Glu Trp Val Ala Xaa 
                725                 730                 735     


Val Xaa Gln Leu Leu Met Gly Ile Glu Gln Ala Leu Ser Ala Asp Ser 
            740                 745                 750         


Ser Gly Ser Ile Leu Lys Val Ser Ser Ser Xaa Xaa Gly Leu Val Arg 
        755                 760                 765             


Leu Xaa Asn Asn Leu Ile Gln Val Ile Asp Cys Ser Met Ala Val Gln 
    770                 775                 780                 


Glu Glu Ala Lys Glu Pro His Val Ser Ser Val Leu Pro Trp Ile Ile 
785                 790                 795                 800 


Leu His Arg Ile Ile Trp Gln Glu Glu Asp Xaa Phe His Ser Leu Cys 
                805                 810                 815     


His Gln Gln Gln Leu Gln Asn Pro Ala Glu Glu Gly Met Ser Glu Xaa 
            820                 825                 830         


Pro Met Leu Pro Ser Ser Leu Met Leu Leu Asn Xaa Ala His Glu Tyr 
        835                 840                 845             


Leu Gly Arg Arg Ser Trp Cys Cys Asn Ser Asp Gly Ala Leu Leu Arg 
    850                 855                 860                 


Phe Tyr Val Arg Val Leu Gln Lys Glu Leu Ala Ala Ser Xaa Ser Glu 
865                 870                 875                 880 


Asp Xaa His Pro Tyr Lys Glu Glu Leu Glu Xaa Ala Leu Glu Gln Cys 
                885                 890                 895     


Phe Tyr Cys Leu Tyr Ser Phe Pro Ser Lys Lys Ser Lys Ala Arg Tyr 
            900                 905                 910         


Leu Glu Glu His Ser Ala Gln Gln Val Asp Leu Ile Trp Glu Asp Ala 
        915                 920                 925             


Leu Phe Met Phe Glu Tyr Phe Lys Pro Lys Xaa Leu Pro Glu Phe Asp 
    930                 935                 940                 


Ser Tyr Lys Xaa Ser Xaa Val Ser Ala Asp Leu Ala Asn Leu Leu Lys 
945                 950                 955                 960 


Arg Ile Ala Xaa Ile Val Pro Arg Xaa Glu Arg Pro Ala Leu Ser Leu 
                965                 970                 975     


Asp Lys Val Ser Ala Tyr Ile Glu Gly Xaa Ser Xaa Glu Val Pro Cys 
            980                 985                 990         


Leu Pro Glu Gly Ala Asp Pro Ser  Pro Pro Val Val Asn  Glu Leu Tyr 
        995                 1000                 1005             


Tyr Leu  Leu Ala Asp Tyr His  Phe Lys Asn Lys Glu  Gln Ser Lys 
    1010                 1015                 1020             


Ala Ile  Lys Phe Tyr Met His  Asp Ile Cys Ile Cys  Pro Asn Arg 
    1025                 1030                 1035             


Phe Asp  Ser Trp Ala Gly Met  Ala Leu Ala Arg Ala  Ser Arg Ile 
    1040                 1045                 1050             


Gln Asp  Lys Leu Asn Ser Asn  Glu Leu Lys Ser Asp  Gly Pro Ile 
    1055                 1060                 1065             


Trp Lys  His Ala Xaa Pro Val  Leu Asn Cys Phe Arg  Arg Ala Leu 
    1070                 1075                 1080             


Glu Ile  Asp Ser Ser Asn Leu  Ser Leu Trp Ile Glu  Tyr Gly Xaa 
    1085                 1090                 1095             


Met Ser  Tyr Ala Leu His Ser  Phe Ala Ser Arg Gln  Leu Lys Gln 
    1100                 1105                 1110             


Trp Arg  Gly Glu Leu Pro Pro  Glu Leu Val Gln Gln  Met Glu Gly 
    1115                 1120                 1125             


Arg Arg  Asp Ser Met Leu Glu  Xaa Ala Lys His Cys  Phe Xaa Ser 
    1130                 1135                 1140             


Ala Ala  Arg Cys Glu Gly Asp  Gly Asp Glu Glu Glu  Trp Leu Ile 
    1145                 1150                 1155             


His Tyr  Met Leu Gly Lys Val  Ala Glu Lys Gln Gln  Gln Pro Pro 
    1160                 1165                 1170             


Xaa Val  Tyr Leu Leu His Tyr  Arg Gln Ala Gly His  Tyr Leu His 
    1175                 1180                 1185             


Glu Glu  Ala Ala Arg Tyr Pro  Lys Lys Ile His Tyr  His Asn Pro 
    1190                 1195                 1200             


Pro Glu  Leu Ala Met Glu Ala  Leu Glu Val Tyr Phe  Arg Leu His 
    1205                 1210                 1215             


Ala Ser  Ile Leu Lys Leu Leu  Gly Lys Pro Asp Ser  Gly Val Gly 
    1220                 1225                 1230             


Ala Glu  Val Leu Val Asn Phe  Met Lys Glu Ala Ala  Glu Gly Pro 
    1235                 1240                 1245             


Phe Ala  Arg Gly Glu Glu Lys  Asn Xaa Pro Lys Ala  Ser Glu Lys 
    1250                 1255                 1260             


Glu Lys  Ala Cys Leu Val Asp  Glu Asp Ser His Ser  Ser Ala Gly 
    1265                 1270                 1275             


Xaa Leu  Pro Gly Pro Gly Ala  Ser Leu Pro Ser Ser  Ser Gly Pro 
    1280                 1285                 1290             


Asp Arg  Ser Gln Asp Ser Xaa  Ala Val Ala Leu Ser  Asp Ser Ser 
    1295                 1300                 1305             


Ser Xaa  Gln Asp Phe Phe Asn  Glu Pro Xaa Ser Leu  Leu Glu Gly 
    1310                 1315                 1320             


Ser Arg  Lys Ser Tyr Xaa Glu  Lys Arg Leu Pro Ile  Leu Ser Ser 
    1325                 1330                 1335             


Gln Ala  Gly Ala Xaa Gly Lys  Asp Leu Gln Gly Ala  Xaa Glu Glu 
    1340                 1345                 1350             


Arg Gly  Lys Asn Glu Glu Ser  Leu Glu Ser Xaa Glu  Gly Phe Arg 
    1355                 1360                 1365             


Ala Ala  Glu Gln Gly Val Gln  Lys Pro Ala Ala Glu  Xaa Pro Ala 
    1370                 1375                 1380             


Ser Ala  Cys Ile Pro Gly Lys  Pro Ser Ala Ser Xaa  Pro Xaa Leu 
    1385                 1390                 1395             


Trp Asp  Gly Lys Lys Arg Gly  Asp Leu Pro Gly Glu  Pro Val Ala 
    1400                 1405                 1410             


Phe Pro  Gln Gly Leu Pro Ala  Gly Ala Glu Glu Gln  Arg Gln Phe 
    1415                 1420                 1425             


Leu Xaa  Glu Gln Cys Ile Ala  Ser Phe Arg Leu Cys  Leu Ser Arg 
    1430                 1435                 1440             


Phe Pro  Gln His Tyr Lys Ser  Leu Tyr Arg Leu Ala  Phe Leu Tyr 
    1445                 1450                 1455             


Xaa Tyr  Ser Lys Xaa His Arg  Asn Leu Gln Trp Ala  Arg Asp Val 
    1460                 1465                 1470             


Leu Leu  Gly Ser Ser Ile Pro  Trp Gln Gln Leu Gln  His Met Pro 
    1475                 1480                 1485             


Ala Gln  Gly Leu Phe Cys Glu  Arg Asn Lys Xaa Asn  Phe Phe Asn 
    1490                 1495                 1500             


Gly Ile  Trp Arg Ile Pro Val  Asp Glu Ile Asp Arg  Pro Gly Ser 
    1505                 1510                 1515             


Phe Ala  Trp His Met Asn Arg  Ser Ile Val Leu Leu  Leu Lys Val 
    1520                 1525                 1530             


Leu Ala  Gln Leu Arg Asp His  Ser Xaa Leu Leu Lys  Val Ser Ser 
    1535                 1540                 1545             


Met Leu  Gln Arg Xaa Pro Asp  Gln Gly Lys Lys Tyr  Leu Arg Asp 
    1550                 1555                 1560             


Ala Asp  Arg Gln Val Leu Ala  Gln Arg Ala Phe Ile  Leu Xaa Val 
    1565                 1570                 1575             


Lys Val  Leu Glu Asp Xaa Leu  Ser Glu Leu Ala Glu  Gly Ser Glu 
    1580                 1585                 1590             


Arg Pro  Gly Pro Lys Val Cys  Gly Leu Pro Gly Ala  Arg Met Xaa 
    1595                 1600                 1605             


Xaa Asp  Val Ser His Lys Ala  Ser Pro Glu Asp Gly  Gln Glu Gly 
    1610                 1615                 1620             


Leu Pro  Gln Pro Lys Lys Pro  Pro Leu Ala Asp Gly  Ser Gly Pro 
    1625                 1630                 1635             


Gly Pro  Glu Pro Gly Gly Lys  Val Gly Leu Leu Asn  His Arg Pro 
    1640                 1645                 1650             


Val Ala  Met Asp Ala Gly Asp  Ser Ala Asp Gln Ser  Gly Glu Arg 
    1655                 1660                 1665             


Lys Asp  Lys Glu Ser Pro Arg  Ala Gly Pro Xaa Glu  Pro Met Asp 
    1670                 1675                 1680             


Xaa Ser  Glu Ala Xaa Val Cys  His Ser Asp Leu Glu  Arg Xaa Pro 
    1685                 1690                 1695             


Pro Leu  Leu Pro Gly Arg Pro  Ala Arg Asp Arg Gly  Pro Glu Ser 
    1700                 1705                 1710             


Arg Pro  Xaa Glu Leu Ser Leu  Glu Glu Leu Ser Ile  Ser Ala Arg 
    1715                 1720                 1725             


Gln Gln  Pro Xaa Pro Leu Xaa  Pro Ala Gln Pro Ala  Pro Ala Pro 
    1730                 1735                 1740             


Ala Pro  Ala Xaa Xaa Xaa Gly  Xaa Arg Ala Gly Gly  His Pro Glu 
    1745                 1750                 1755             


Glu Pro  Leu Ser Arg Leu Ser  Arg Lys Arg Lys Leu  Leu Glu Asp 
    1760                 1765                 1770             


Xaa Glu  Ser Gly Lys Xaa Leu  Leu Leu Asp Ala Tyr  Arg Val Trp 
    1775                 1780                 1785             


Gln Gln  Gly Gln Lys Gly Val  Ala Tyr Asp Leu Gly  Arg Val Glu 
    1790                 1795                 1800             


Arg Ile  Met Ser Glu Xaa Tyr  Met Leu Ile Lys Gln  Val Asp Glu 
    1805                 1810                 1815             


Glu Ala  Ala Leu Glu Gln Ala  Val Lys Phe Cys Gln  Val His Leu 
    1820                 1825                 1830             


Gly Ala  Ala Ala Gln Arg Gln  Ala Ser Gly Asp Xaa  Pro Xaa Xaa 
    1835                 1840                 1845             


Pro Lys  His Pro Lys Asp Ser  Arg Glu Asn Phe Phe  Pro Val Xaa 
    1850                 1855                 1860             


Val Val  Pro Xaa Ala Pro Asp  Pro Val Pro Ala Asp  Ser Val Gln 
    1865                 1870                 1875             


Arg Pro  Ser Asp Ala His Xaa  Lys Pro Arg Pro Ala  Leu Ala Ala 
    1880                 1885                 1890             


Ala Xaa  Xaa Ile Ile Xaa Cys  Pro Pro Ser Ala Ser  Ala Ser Xaa 
    1895                 1900                 1905             


Leu Asp  Gln Ser Lys Asp Pro  Gly Pro Pro Arg Pro  His Arg Pro 
    1910                 1915                 1920             


Glu Ala  Xaa Pro Ser Met Ala  Ser Leu Gly Pro Glu  Gly Glu Glu 
    1925                 1930                 1935             


Leu Ala  Arg Val Ala Glu Gly  Xaa Ser Phe Pro Pro  Gln Glu Pro 
    1940                 1945                 1950             


Arg His  Ser Pro Gln Val Lys  Met Ala Pro Xaa Ser  Ser Pro Ala 
    1955                 1960                 1965             


Glu Pro  His Cys Trp Pro Ala  Glu Ala Ala Leu Gly  Xaa Gly Ala 
    1970                 1975                 1980             


Glu Pro  Xaa Cys Ser Gln Glu  Gly Lys Leu Arg Pro  Glu Pro Arg 
    1985                 1990                 1995             


Arg Asp  Gly Glu Ala Gln Glu  Ala Ala Ser Glu Xaa  Gln Pro Leu 
    2000                 2005                 2010             


Ser Ser  Pro Pro Xaa Ala Ala  Ser Ser Lys Ala Pro  Ser Ser Gly 
    2015                 2020                 2025             


Ser Ala  Gln Pro Pro Glu Gly  His Pro Gly Lys Pro  Glu Pro Ser 
    2030                 2035                 2040             


Arg Ala  Lys Ser Arg Pro Leu  Pro Asn Met Pro Lys  Leu Val Ile 
    2045                 2050                 2055             


Pro Ser  Ala Ala Xaa Lys Phe  Pro Pro Glu Ile Xaa  Val Xaa Pro 
    2060                 2065                 2070             


Pro Xaa  Pro Xaa Leu Leu Ser  Pro Lys Gly Ser Ile  Ser Glu Glu 
    2075                 2080                 2085             


Xaa Lys  Gln Lys Leu Lys Ser  Ala Ile Leu Ser Ala  Gln Ser Ala 
    2090                 2095                 2100             


Ala Asn  Val Arg Lys Glu Ser  Leu Cys Gln Pro Ala  Leu Glu Val 
    2105                 2110                 2115             


Leu Glu  Xaa Ser Ser Gln Glu  Ser Ser Leu Glu Ser  Glu Xaa Asp 
    2120                 2125                 2130             


Glu Asp  Asp Asp Tyr Met Asp  Ile 
    2135                 2140     


<210> 4614
<211> 2170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1296)..(1296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1320)..(1320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1339)..(1339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1347)..(1347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1372)..(1372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1380)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1393)..(1393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1410)..(1410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1424)..(1424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1426)..(1426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1459)..(1459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1488)..(1488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1492)..(1492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1528)..(1528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1571)..(1571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1613)..(1613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1637)..(1638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1708)..(1708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1713)..(1713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1717)..(1717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1726)..(1726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1745)..(1745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1764)..(1764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1776)..(1778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1780)..(1780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1803)..(1803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1808)..(1808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1838)..(1838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1874)..(1874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1876)..(1877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1892)..(1892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1896)..(1896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1914)..(1914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1924)..(1925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1928)..(1928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1937)..(1937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1955)..(1955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1975)..(1975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1993)..(1993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2010)..(2010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2015)..(2015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2039)..(2039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2047)..(2047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2092)..(2092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2099)..(2099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2101)..(2101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2104)..(2104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2106)..(2106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2118)..(2118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2150)..(2150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2161)..(2161)
<223> Selenocysteine

<400> 4614
Met Ile Arg Ile Ala Ala Leu Asn Ala Ser Ser Xaa Ile Glu Asp Asp 
1               5                   10                  15      


His Glu Gly Ser Phe Lys Ser His Lys Xaa Gln Xaa Lys Glu Ala Gln 
            20                  25                  30          


Glu Ala Glu Ala Phe Ala Leu Tyr His Lys Ala Leu Asp Leu Gln Lys 
        35                  40                  45              


His Asp Arg Phe Glu Glu Ser Ala Lys Ala Tyr His Glu Leu Leu Glu 
    50                  55                  60                  


Ala Ser Leu Leu Arg Glu Ala Val Ser Ser Gly Asp Glu Lys Glu Gly 
65                  70                  75                  80  


Leu Lys His Pro Gly Leu Ile Leu Lys Tyr Ser Xaa Tyr Lys Asn Leu 
                85                  90                  95      


Ala Gln Leu Ala Ala Gln Arg Glu Asp Leu Glu Xaa Ala Met Glu Phe 
            100                 105                 110         


Tyr Leu Glu Ala Val Met Leu Asp Ser Xaa Asp Val Asn Leu Trp Tyr 
        115                 120                 125             


Lys Ile Gly His Val Ala Leu Arg Leu Ile Arg Ile Pro Leu Ala Arg 
    130                 135                 140                 


His Ala Phe Glu Glu Gly Leu Arg Cys Asn Pro Asp His Trp Pro Cys 
145                 150                 155                 160 


Leu Asp Asn Leu Ile Xaa Val Leu Tyr Xaa Leu Ser Asp Tyr Xaa Xaa 
                165                 170                 175     


Cys Leu Tyr Phe Ile Cys Lys Ala Leu Glu Lys Asp Cys Arg Tyr Ser 
            180                 185                 190         


Lys Gly Leu Val Leu Lys Glu Lys Ile Phe Glu Glu Gln Pro Cys Leu 
        195                 200                 205             


Arg Lys Asp Ser Leu Arg Met Phe Leu Lys Cys Trp Lys Cys Leu Gly 
    210                 215                 220                 


Glu Ser Leu Leu Ala Met Tyr Asn His Leu Xaa Xaa Cys Glu Pro Pro 
225                 230                 235                 240 


Arg Pro Ser Leu Gly Lys Arg Ile Asp Leu Ser Asp Tyr Gln Asp Pro 
                245                 250                 255     


Ser Gln Pro Leu Glu Ser Ser Met Val Val Xaa Pro Val Asn Val Ile 
            260                 265                 270         


Gln Pro Ser Xaa Val Ser Xaa Asn Pro Ala Val Ala Val Ala Glu Pro 
        275                 280                 285             


Val Val Ser Tyr Xaa Ser Val Ala Xaa Xaa Ser Phe Pro Leu His Ser 
    290                 295                 300                 


Pro Gly Leu Leu Glu Xaa Gly Ala Pro Val Gly Asp Ile Ser Gly Gly 
305                 310                 315                 320 


Asp Lys Ser Lys Lys Gly Val Lys Arg Lys Lys Ile Ser Glu Glu Ser 
                325                 330                 335     


Gly Glu Xaa Ala Lys Arg Arg Ser Ala Arg Val Arg Asn Xaa Lys Cys 
            340                 345                 350         


Lys Lys Glu Glu Lys Val Asp Phe Gln Glu Leu Leu Met Lys Phe Leu 
        355                 360                 365             


Pro Ser Arg Leu Arg Lys Leu Asp Pro Glu Glu Glu Asp Asp Ser Phe 
    370                 375                 380                 


Asn Asn Tyr Glu Val Gln Ser Glu Ala Lys Leu Glu Ser Phe Pro Ser 
385                 390                 395                 400 


Ile Gly Pro Gln Arg Leu Ser Phe Asp Ser Ala Xaa Phe Met Glu Ser 
                405                 410                 415     


Glu Lys Gln Asp Val His Glu Phe Leu Leu Glu Asn Leu Xaa Asn Gly 
            420                 425                 430         


Gly Ile Leu Glu Leu Met Met Arg Tyr Leu Lys Ala Met Gly His Lys 
        435                 440                 445             


Phe Leu Val Arg Trp Pro Pro Gly Leu Ala Glu Val Val Leu Ser Val 
    450                 455                 460                 


Tyr His Ser Trp Arg Arg His Ser Xaa Ser Leu Pro Asn Pro Leu Leu 
465                 470                 475                 480 


Arg Asp Cys Ser Asn Lys His Ile Lys Asp Met Met Leu Met Ser Leu 
                485                 490                 495     


Ser Cys Met Glu Leu Gln Leu Asp Gln Trp Leu Leu Xaa Lys Gly Arg 
            500                 505                 510         


Ser Ser Ala Val Ser Pro Arg Asn Cys Pro Ala Gly Met Val Asn Gly 
        515                 520                 525             


Arg Phe Gly Pro Asp Phe Pro Gly Xaa His Cys Leu Gly Asp Leu Leu 
    530                 535                 540                 


Gln Leu Ser Phe Ala Ser Ser Gln Arg Asp Leu Phe Glu Asp Gly Trp 
545                 550                 555                 560 


Leu Glu Phe Val Val Arg Val Tyr Trp Leu Lys Ala Arg Phe Leu Ala 
                565                 570                 575     


Leu Gln Gly Asp Met Glu Gln Ala Leu Glu Asn Tyr Asp Ile Cys Xaa 
            580                 585                 590         


Glu Met Leu Gln Ser Ser Xaa Ala Ile Gln Val Glu Ala Gly Ala Glu 
        595                 600                 605             


Arg Arg Asp Ile Val Ile Arg Leu Pro Asn Leu His Asn Asp Ser Val 
    610                 615                 620                 


Val Ser Leu Glu Glu Ile Asp Lys Asn Leu Lys Ser Leu Glu Arg Cys 
625                 630                 635                 640 


Gln Ser Leu Glu Glu Ile Gln Arg Leu Tyr Glu Ala Gly Asp Tyr Lys 
                645                 650                 655     


Ala Val Val His Leu Leu Arg Pro Xaa Leu Cys Xaa Ser Gly Phe Asp 
            660                 665                 670         


Arg Ala Lys His Leu Glu Phe Met Xaa Ser Ile Pro Glu Arg Pro Ala 
        675                 680                 685             


Gln Leu Leu Leu Leu Gln Asp Ser Leu Leu Arg Leu Lys Asp Tyr Arg 
    690                 695                 700                 


Gln Cys Phe Glu Cys Ser Asp Val Ala Leu Asn Glu Ala Val Gln Gln 
705                 710                 715                 720 


Met Val Asn Ser Gly Glu Ala Ala Ala Lys Glu Glu Trp Val Ala Xaa 
                725                 730                 735     


Val Xaa Gln Leu Leu Met Gly Ile Glu Gln Ala Leu Ser Ala Asp Ser 
            740                 745                 750         


Ser Gly Ser Ile Leu Lys Val Ser Ser Ser Xaa Xaa Gly Leu Val Arg 
        755                 760                 765             


Leu Xaa Asn Asn Leu Ile Gln Val Ile Asp Cys Ser Met Ala Val Gln 
    770                 775                 780                 


Glu Glu Ala Lys Glu Pro His Val Ser Ser Val Leu Pro Trp Ile Ile 
785                 790                 795                 800 


Leu His Arg Ile Ile Trp Gln Glu Glu Asp Xaa Phe His Ser Leu Cys 
                805                 810                 815     


His Gln Gln Gln Leu Gln Asn Pro Ala Glu Glu Gly Met Ser Glu Xaa 
            820                 825                 830         


Pro Met Leu Pro Ser Ser Leu Met Leu Leu Asn Xaa Ala His Glu Tyr 
        835                 840                 845             


Leu Gly Arg Arg Ser Trp Cys Cys Asn Ser Asp Gly Ala Leu Leu Arg 
    850                 855                 860                 


Phe Tyr Val Arg Val Leu Gln Lys Glu Leu Ala Ala Ser Xaa Ser Glu 
865                 870                 875                 880 


Asp Xaa His Pro Tyr Lys Glu Glu Leu Glu Xaa Ala Leu Glu Gln Cys 
                885                 890                 895     


Phe Tyr Cys Leu Tyr Ser Phe Pro Ser Lys Lys Ser Lys Ala Arg Tyr 
            900                 905                 910         


Leu Glu Glu His Ser Ala Gln Gln Val Asp Leu Ile Trp Glu Asp Ala 
        915                 920                 925             


Leu Phe Met Phe Glu Tyr Phe Lys Pro Lys Xaa Leu Pro Glu Phe Asp 
    930                 935                 940                 


Ser Tyr Lys Xaa Ser Xaa Val Ser Ala Asp Leu Ala Asn Leu Leu Lys 
945                 950                 955                 960 


Arg Ile Ala Xaa Ile Val Pro Arg Xaa Glu Arg Pro Ala Leu Ser Leu 
                965                 970                 975     


Asp Lys Val Ser Ala Tyr Ile Glu Gly Xaa Ser Xaa Glu Val Pro Cys 
            980                 985                 990         


Leu Pro Glu Gly Ala Asp Pro Ser  Pro Pro Val Val Asn  Glu Leu Tyr 
        995                 1000                 1005             


Tyr Leu  Leu Ala Asp Tyr His  Phe Lys Asn Lys Glu  Gln Ser Lys 
    1010                 1015                 1020             


Ala Ile  Lys Phe Tyr Met His  Asp Ile Cys Ile Cys  Pro Asn Arg 
    1025                 1030                 1035             


Phe Asp  Ser Trp Ala Gly Met  Ala Leu Ala Arg Ala  Ser Arg Ile 
    1040                 1045                 1050             


Gln Asp  Lys Leu Asn Ser Asn  Glu Leu Lys Ser Asp  Gly Pro Ile 
    1055                 1060                 1065             


Trp Lys  His Ala Xaa Pro Val  Leu Asn Cys Phe Arg  Arg Ala Leu 
    1070                 1075                 1080             


Glu Ile  Asp Ser Ser Asn Leu  Ser Leu Trp Ile Glu  Tyr Gly Xaa 
    1085                 1090                 1095             


Met Ser  Tyr Ala Leu His Ser  Phe Ala Ser Arg Gln  Leu Lys Gln 
    1100                 1105                 1110             


Trp Arg  Gly Glu Leu Pro Pro  Glu Leu Val Gln Gln  Met Glu Gly 
    1115                 1120                 1125             


Arg Arg  Asp Ser Met Leu Glu  Xaa Ala Lys His Cys  Phe Xaa Ser 
    1130                 1135                 1140             


Ala Ala  Arg Cys Glu Gly Asp  Gly Asp Glu Glu Glu  Trp Leu Ile 
    1145                 1150                 1155             


His Tyr  Met Leu Gly Lys Val  Ala Glu Lys Gln Gln  Gln Pro Pro 
    1160                 1165                 1170             


Xaa Val  Tyr Leu Leu His Tyr  Arg Gln Ala Gly His  Tyr Leu His 
    1175                 1180                 1185             


Glu Glu  Ala Ala Arg Tyr Pro  Lys Lys Ile His Tyr  His Asn Pro 
    1190                 1195                 1200             


Pro Glu  Leu Ala Met Glu Ala  Leu Glu Val Tyr Phe  Arg Leu His 
    1205                 1210                 1215             


Ala Ser  Ile Leu Lys Leu Leu  Gly Lys Pro Asp Ser  Gly Val Gly 
    1220                 1225                 1230             


Ala Glu  Val Leu Val Asn Phe  Met Lys Glu Ala Ala  Glu Gly Pro 
    1235                 1240                 1245             


Phe Ala  Arg Gly Glu Glu Lys  Asn Xaa Pro Lys Ala  Ser Glu Lys 
    1250                 1255                 1260             


Glu Lys  Ala Cys Leu Val Asp  Glu Asp Ser His Ser  Ser Ala Gly 
    1265                 1270                 1275             


Xaa Leu  Pro Gly Pro Gly Ala  Ser Leu Pro Ser Ser  Ser Gly Pro 
    1280                 1285                 1290             


Gly Leu  Xaa Ser Pro Pro Tyr  Xaa Ala Xaa Pro Ile  Asp His Asp 
    1295                 1300                 1305             


Tyr Val  Lys Cys Lys Lys Pro  His Gln Gln Ala Xaa  Pro Asp Asp 
    1310                 1315                 1320             


Arg Ser  Gln Asp Ser Xaa Ala  Val Ala Leu Ser Asp  Ser Ser Ser 
    1325                 1330                 1335             


Xaa Gln  Asp Phe Phe Asn Glu  Pro Xaa Ser Leu Leu  Glu Gly Ser 
    1340                 1345                 1350             


Arg Lys  Ser Tyr Xaa Glu Lys  Arg Leu Pro Ile Leu  Ser Ser Gln 
    1355                 1360                 1365             


Ala Gly  Ala Xaa Gly Lys Asp  Leu Gln Gly Ala Xaa  Glu Glu Arg 
    1370                 1375                 1380             


Gly Lys  Asn Glu Glu Ser Leu  Glu Ser Xaa Glu Gly  Phe Arg Ala 
    1385                 1390                 1395             


Ala Glu  Gln Gly Val Gln Lys  Pro Ala Ala Glu Xaa  Pro Ala Ser 
    1400                 1405                 1410             


Ala Cys  Ile Pro Gly Lys Pro  Ser Ala Ser Xaa Pro  Xaa Leu Trp 
    1415                 1420                 1425             


Asp Gly  Lys Lys Arg Gly Asp  Leu Pro Gly Glu Pro  Val Ala Phe 
    1430                 1435                 1440             


Pro Gln  Gly Leu Pro Ala Gly  Ala Glu Glu Gln Arg  Gln Phe Leu 
    1445                 1450                 1455             


Xaa Glu  Gln Cys Ile Ala Ser  Phe Arg Leu Cys Leu  Ser Arg Phe 
    1460                 1465                 1470             


Pro Gln  His Tyr Lys Ser Leu  Tyr Arg Leu Ala Phe  Leu Tyr Xaa 
    1475                 1480                 1485             


Tyr Ser  Lys Xaa His Arg Asn  Leu Gln Trp Ala Arg  Asp Val Leu 
    1490                 1495                 1500             


Leu Gly  Ser Ser Ile Pro Trp  Gln Gln Leu Gln His  Met Pro Ala 
    1505                 1510                 1515             


Gln Gly  Leu Phe Cys Glu Arg  Asn Lys Xaa Asn Phe  Phe Asn Gly 
    1520                 1525                 1530             


Ile Trp  Arg Ile Pro Val Asp  Glu Ile Asp Arg Pro  Gly Ser Phe 
    1535                 1540                 1545             


Ala Trp  His Met Asn Arg Ser  Ile Val Leu Leu Leu  Lys Val Leu 
    1550                 1555                 1560             


Ala Gln  Leu Arg Asp His Ser  Xaa Leu Leu Lys Val  Ser Ser Met 
    1565                 1570                 1575             


Leu Gln  Arg Xaa Pro Asp Gln  Gly Lys Lys Tyr Leu  Arg Asp Ala 
    1580                 1585                 1590             


Asp Arg  Gln Val Leu Ala Gln  Arg Ala Phe Ile Leu  Xaa Val Lys 
    1595                 1600                 1605             


Val Leu  Glu Asp Xaa Leu Ser  Glu Leu Ala Glu Gly  Ser Glu Arg 
    1610                 1615                 1620             


Pro Gly  Pro Lys Val Cys Gly  Leu Pro Gly Ala Arg  Met Xaa Xaa 
    1625                 1630                 1635             


Asp Val  Ser His Lys Ala Ser  Pro Glu Asp Gly Gln  Glu Gly Leu 
    1640                 1645                 1650             


Pro Gln  Pro Lys Lys Pro Pro  Leu Ala Asp Gly Ser  Gly Pro Gly 
    1655                 1660                 1665             


Pro Glu  Pro Gly Gly Lys Val  Gly Leu Leu Asn His  Arg Pro Val 
    1670                 1675                 1680             


Ala Met  Asp Ala Gly Asp Ser  Ala Asp Gln Ser Gly  Glu Arg Lys 
    1685                 1690                 1695             


Asp Lys  Glu Ser Pro Arg Ala  Gly Pro Xaa Glu Pro  Met Asp Xaa 
    1700                 1705                 1710             


Ser Glu  Ala Xaa Val Cys His  Ser Asp Leu Glu Arg  Xaa Pro Pro 
    1715                 1720                 1725             


Leu Leu  Pro Gly Arg Pro Ala  Arg Asp Arg Gly Pro  Glu Ser Arg 
    1730                 1735                 1740             


Pro Xaa  Glu Leu Ser Leu Glu  Glu Leu Ser Ile Ser  Ala Arg Gln 
    1745                 1750                 1755             


Gln Pro  Xaa Pro Leu Xaa Pro  Ala Gln Pro Ala Pro  Ala Pro Ala 
    1760                 1765                 1770             


Pro Ala  Xaa Xaa Xaa Gly Xaa  Arg Ala Gly Gly His  Pro Glu Glu 
    1775                 1780                 1785             


Pro Leu  Ser Arg Leu Ser Arg  Lys Arg Lys Leu Leu  Glu Asp Xaa 
    1790                 1795                 1800             


Glu Ser  Gly Lys Xaa Leu Leu  Leu Asp Ala Tyr Arg  Val Trp Gln 
    1805                 1810                 1815             


Gln Gly  Gln Lys Gly Val Ala  Tyr Asp Leu Gly Arg  Val Glu Arg 
    1820                 1825                 1830             


Ile Met  Ser Glu Xaa Tyr Met  Leu Ile Lys Gln Val  Asp Glu Glu 
    1835                 1840                 1845             


Ala Ala  Leu Glu Gln Ala Val  Lys Phe Cys Gln Val  His Leu Gly 
    1850                 1855                 1860             


Ala Ala  Ala Gln Arg Gln Ala  Ser Gly Asp Xaa Pro  Xaa Xaa Pro 
    1865                 1870                 1875             


Lys His  Pro Lys Asp Ser Arg  Glu Asn Phe Phe Pro  Val Xaa Val 
    1880                 1885                 1890             


Val Pro  Xaa Ala Pro Asp Pro  Val Pro Ala Asp Ser  Val Gln Arg 
    1895                 1900                 1905             


Pro Ser  Asp Ala His Xaa Lys  Pro Arg Pro Ala Leu  Ala Ala Ala 
    1910                 1915                 1920             


Xaa Xaa  Ile Ile Xaa Cys Pro  Pro Ser Ala Ser Ala  Ser Xaa Leu 
    1925                 1930                 1935             


Asp Gln  Ser Lys Asp Pro Gly  Pro Pro Arg Pro His  Arg Pro Glu 
    1940                 1945                 1950             


Ala Xaa  Pro Ser Met Ala Ser  Leu Gly Pro Glu Gly  Glu Glu Leu 
    1955                 1960                 1965             


Ala Arg  Val Ala Glu Gly Xaa  Ser Phe Pro Pro Gln  Glu Pro Arg 
    1970                 1975                 1980             


His Ser  Pro Gln Val Lys Met  Ala Pro Xaa Ser Ser  Pro Ala Glu 
    1985                 1990                 1995             


Pro His  Cys Trp Pro Ala Glu  Ala Ala Leu Gly Xaa  Gly Ala Glu 
    2000                 2005                 2010             


Pro Xaa  Cys Ser Gln Glu Gly  Lys Leu Arg Pro Glu  Pro Arg Arg 
    2015                 2020                 2025             


Asp Gly  Glu Ala Gln Glu Ala  Ala Ser Glu Xaa Gln  Pro Leu Ser 
    2030                 2035                 2040             


Ser Pro  Pro Xaa Ala Ala Ser  Ser Lys Ala Pro Ser  Ser Gly Ser 
    2045                 2050                 2055             


Ala Gln  Pro Pro Glu Gly His  Pro Gly Lys Pro Glu  Pro Ser Arg 
    2060                 2065                 2070             


Ala Lys  Ser Arg Pro Leu Pro  Asn Met Pro Lys Leu  Val Ile Pro 
    2075                 2080                 2085             


Ser Ala  Ala Xaa Lys Phe Pro  Pro Glu Ile Xaa Val  Xaa Pro Pro 
    2090                 2095                 2100             


Xaa Pro  Xaa Leu Leu Ser Pro  Lys Gly Ser Ile Ser  Glu Glu Xaa 
    2105                 2110                 2115             


Lys Gln  Lys Leu Lys Ser Ala  Ile Leu Ser Ala Gln  Ser Ala Ala 
    2120                 2125                 2130             


Asn Val  Arg Lys Glu Ser Leu  Cys Gln Pro Ala Leu  Glu Val Leu 
    2135                 2140                 2145             


Glu Xaa  Ser Ser Gln Glu Ser  Ser Leu Glu Ser Glu  Xaa Asp Glu 
    2150                 2155                 2160             


Asp Asp  Asp Tyr Met Asp Ile  
    2165                 2170 


<210> 4615
<211> 590
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<400> 4615
Met Pro Arg Arg Ser Arg Arg Gly Ile Trp Arg Ile Pro Val Asp Glu 
1               5                   10                  15      


Ile Asp Arg Pro Gly Ser Phe Ala Trp His Met Asn Arg Ser Ile Val 
            20                  25                  30          


Leu Leu Leu Lys Val Leu Ala Gln Leu Arg Asp His Ser Xaa Leu Leu 
        35                  40                  45              


Lys Val Ser Ser Met Leu Gln Arg Xaa Pro Asp Gln Gly Lys Lys Tyr 
    50                  55                  60                  


Leu Arg Asp Ala Asp Arg Gln Val Leu Ala Gln Arg Ala Phe Ile Leu 
65                  70                  75                  80  


Xaa Val Lys Val Leu Glu Asp Xaa Leu Ser Glu Leu Ala Glu Gly Ser 
                85                  90                  95      


Glu Arg Pro Gly Pro Lys Val Cys Gly Leu Pro Gly Ala Arg Met Xaa 
            100                 105                 110         


Xaa Asp Val Ser His Lys Ala Ser Pro Glu Asp Gly Gln Glu Gly Leu 
        115                 120                 125             


Pro Gln Pro Lys Lys Pro Pro Leu Ala Asp Gly Ser Gly Pro Gly Pro 
    130                 135                 140                 


Glu Pro Gly Gly Lys Val Gly Leu Leu Asn His Arg Pro Val Ala Met 
145                 150                 155                 160 


Asp Ala Gly Asp Ser Ala Asp Gln Ser Gly Glu Arg Lys Asp Lys Glu 
                165                 170                 175     


Ser Pro Arg Ala Gly Pro Xaa Glu Pro Met Asp Xaa Ser Glu Ala Xaa 
            180                 185                 190         


Val Cys His Ser Asp Leu Glu Arg Xaa Pro Pro Leu Leu Pro Gly Arg 
        195                 200                 205             


Pro Ala Arg Asp Arg Gly Pro Glu Ser Arg Pro Xaa Glu Leu Ser Leu 
    210                 215                 220                 


Glu Glu Leu Ser Ile Ser Ala Arg Gln Gln Pro Xaa Pro Leu Xaa Pro 
225                 230                 235                 240 


Ala Gln Pro Ala Pro Ala Pro Ala Pro Ala Xaa Xaa Xaa Gly Xaa Arg 
                245                 250                 255     


Ala Gly Gly His Pro Glu Glu Pro Leu Ser Arg Leu Ser Arg Lys Arg 
            260                 265                 270         


Lys Leu Leu Glu Asp Xaa Glu Ser Gly Lys Xaa Leu Leu Leu Asp Ala 
        275                 280                 285             


Tyr Arg Val Trp Gln Gln Gly Gln Lys Gly Val Ala Tyr Asp Leu Gly 
    290                 295                 300                 


Arg Val Glu Arg Ile Met Ser Glu Xaa Tyr Met Leu Ile Lys Gln Val 
305                 310                 315                 320 


Asp Glu Glu Ala Ala Leu Glu Gln Ala Val Lys Phe Cys Gln Val His 
                325                 330                 335     


Leu Gly Ala Ala Ala Gln Arg Gln Ala Ser Gly Asp Xaa Pro Xaa Xaa 
            340                 345                 350         


Pro Lys His Pro Lys Asp Ser Arg Glu Asn Phe Phe Pro Val Xaa Val 
        355                 360                 365             


Val Pro Xaa Ala Pro Asp Pro Val Pro Ala Asp Ser Val Gln Arg Pro 
    370                 375                 380                 


Ser Asp Ala His Xaa Lys Pro Arg Pro Ala Leu Ala Ala Ala Xaa Xaa 
385                 390                 395                 400 


Ile Ile Xaa Cys Pro Pro Ser Ala Ser Ala Ser Xaa Leu Asp Gln Ser 
                405                 410                 415     


Lys Asp Pro Gly Pro Pro Arg Pro His Arg Pro Glu Ala Xaa Pro Ser 
            420                 425                 430         


Met Ala Ser Leu Gly Pro Glu Gly Lys Leu Arg Pro Glu Pro Arg Arg 
        435                 440                 445             


Asp Gly Glu Ala Gln Glu Ala Ala Ser Glu Xaa Gln Pro Leu Ser Ser 
    450                 455                 460                 


Pro Pro Xaa Ala Ala Ser Ser Lys Ala Pro Ser Ser Gly Ser Ala Gln 
465                 470                 475                 480 


Pro Pro Glu Gly His Pro Gly Lys Pro Glu Pro Ser Arg Ala Lys Ser 
                485                 490                 495     


Arg Pro Leu Pro Asn Met Pro Lys Leu Val Ile Pro Ser Ala Ala Xaa 
            500                 505                 510         


Lys Phe Pro Pro Glu Ile Xaa Val Xaa Pro Pro Xaa Pro Xaa Leu Leu 
        515                 520                 525             


Ser Pro Lys Gly Ser Ile Ser Glu Glu Xaa Lys Gln Lys Leu Lys Ser 
    530                 535                 540                 


Ala Ile Leu Ser Ala Gln Ser Ala Ala Asn Val Arg Lys Glu Ser Leu 
545                 550                 555                 560 


Cys Gln Pro Ala Leu Glu Val Leu Glu Xaa Ser Ser Gln Glu Ser Ser 
                565                 570                 575     


Leu Glu Ser Glu Xaa Asp Glu Asp Asp Asp Tyr Met Asp Ile 
            580                 585                 590 


<210> 4616
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 4616
Met Ala Gln Pro Gln Gly Pro Ala Glu Gly Ser Leu Pro Xaa Gly Asp 
1               5                   10                  15      


Pro Ser Pro Ser Glu Gly Xaa Pro Gly Xaa Ser Gln Ala Pro Gly Ser 
            20                  25                  30          


Pro Ala Ala Xaa Arg Arg Arg Glu Leu Leu Arg Glu Leu Glu Ala Gln 
        35                  40                  45              


Val Gln Ala Ala Tyr Gly Gln Asp Arg Glu Leu Arg Pro Glu Glu Ile 
    50                  55                  60                  


Glu Glu Leu Gln Val Ala Phe Gln Glu Phe Asp Arg Asp Arg Asp Gly 
65                  70                  75                  80  


Tyr Ile Gly Cys Arg Glu Leu Gly Ala Cys Met Arg Xaa Leu Gly Tyr 
                85                  90                  95      


Met Pro Xaa Glu Met Glu Leu Ile Glu Ile Ser Gln Gln Ile Ser Gly 
            100                 105                 110         


Gly Lys Val Asp Phe Glu Asp Phe Val Glu Leu Met Gly Pro Lys Leu 
        115                 120                 125             


Leu Ala Glu Xaa Ala Asp Met Ile Gly Val Arg Glu Leu Arg Asp Ala 
    130                 135                 140                 


Phe Arg Glu Phe Asp Xaa Asn Gly Asp Gly Arg Ile Ser Val Gly Glu 
145                 150                 155                 160 


Leu Arg Ala Ala Leu Lys Ala Leu Leu Gly Glu Arg Leu Ser Gln Arg 
                165                 170                 175     


Glu Val Asp Glu Ile Leu Gln Asp Val Asp Leu Asn Gly Asp Gly Leu 
            180                 185                 190         


Val Asp Phe Glu Glu Phe Val Arg Met Met Ser Arg 
        195                 200                 


<210> 4617
<211> 220
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 4617
Met Gly Asn Cys Ala Lys Arg Pro Trp Arg Arg Gly Pro Lys Asp Pro 
1               5                   10                  15      


Leu Gln Trp Leu Gly Ser Pro Pro Arg Gly Ser Cys Pro Ser Pro Ser 
            20                  25                  30          


Ser Ser Pro Lys Glu Gln Gly Asp Pro Ala Pro Gly Val Gln Gly Tyr 
        35                  40                  45              


Ser Val Leu Asn Ser Leu Val Gly Pro Ala Cys Ile Phe Leu Arg Pro 
    50                  55                  60                  


Ser Ile Ala Ala Xaa Gln Leu Asp Arg Glu Leu Arg Pro Glu Glu Ile 
65                  70                  75                  80  


Glu Glu Leu Gln Val Ala Phe Gln Glu Phe Asp Arg Asp Arg Asp Gly 
                85                  90                  95      


Tyr Ile Gly Cys Arg Glu Leu Gly Ala Cys Met Arg Xaa Leu Gly Tyr 
            100                 105                 110         


Met Pro Xaa Glu Met Glu Leu Ile Glu Ile Ser Gln Gln Ile Ser Gly 
        115                 120                 125             


Gly Lys Val Asp Phe Glu Asp Phe Val Glu Leu Met Gly Pro Lys Leu 
    130                 135                 140                 


Leu Ala Glu Xaa Ala Asp Met Ile Gly Val Arg Glu Leu Arg Asp Ala 
145                 150                 155                 160 


Phe Arg Glu Phe Asp Xaa Asn Gly Asp Gly Arg Ile Ser Val Gly Glu 
                165                 170                 175     


Leu Arg Ala Ala Leu Lys Ala Leu Leu Gly Glu Arg Leu Ser Gln Arg 
            180                 185                 190         


Glu Val Asp Glu Ile Leu Gln Asp Val Asp Leu Asn Gly Asp Gly Leu 
        195                 200                 205             


Val Asp Phe Glu Glu Phe Val Arg Met Met Ser Arg 
    210                 215                 220 


<210> 4618
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<400> 4618
Met Gly Asn Cys Ala Lys Arg Pro Trp Arg Arg Gly Pro Lys Asp Pro 
1               5                   10                  15      


Leu Gln Trp Leu Gly Ser Pro Pro Arg Gly Ser Cys Pro Ser Pro Ser 
            20                  25                  30          


Ser Ser Pro Lys Glu Gln Gly Asp Pro Ala Pro Gly Val Gln Gly Tyr 
        35                  40                  45              


Ser Val Leu Asn Ser Leu Val Gly Pro Ala Cys Ile Phe Leu Arg Pro 
    50                  55                  60                  


Ser Ile Ala Ala Xaa Gln Leu Val 
65                  70          


<210> 4619
<211> 163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<400> 4619
Met Gly Asn Cys Ala Lys Arg Pro Trp Arg Arg Gly Pro Lys Asp Arg 
1               5                   10                  15      


Glu Leu Arg Pro Glu Glu Ile Glu Glu Leu Gln Val Ala Phe Gln Glu 
            20                  25                  30          


Phe Asp Arg Asp Arg Asp Gly Tyr Ile Gly Cys Arg Glu Leu Gly Ala 
        35                  40                  45              


Cys Met Arg Xaa Leu Gly Tyr Met Pro Xaa Glu Met Glu Leu Ile Glu 
    50                  55                  60                  


Ile Ser Gln Gln Ile Ser Gly Gly Lys Val Asp Phe Glu Asp Phe Val 
65                  70                  75                  80  


Glu Leu Met Gly Pro Lys Leu Leu Ala Glu Xaa Ala Asp Met Ile Gly 
                85                  90                  95      


Val Arg Glu Leu Arg Asp Ala Phe Arg Glu Phe Asp Xaa Asn Gly Asp 
            100                 105                 110         


Gly Arg Ile Ser Val Gly Glu Leu Arg Ala Ala Leu Lys Ala Leu Leu 
        115                 120                 125             


Gly Glu Arg Leu Ser Gln Arg Glu Val Asp Glu Ile Leu Gln Asp Val 
    130                 135                 140                 


Asp Leu Asn Gly Asp Gly Leu Val Asp Phe Glu Glu Phe Val Arg Met 
145                 150                 155                 160 


Met Ser Arg 
            


<210> 4620
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<400> 4620
Met Xaa Glu Pro Trp Leu Ala Leu Gly Xaa Ser Trp Xaa Leu Pro Leu 
1               5                   10                  15      


Gln Asp Arg Glu Leu Gly Pro Glu Glu Leu Asp Glu Leu Gln Ala Ala 
            20                  25                  30          


Phe Glu Glu Phe Asp Xaa Asp Arg Asp Gly Tyr Ile Ser His Arg Glu 
        35                  40                  45              


Leu Gly Asp Cys Met Arg Xaa Leu Gly Tyr Met Pro Xaa Glu Met Glu 
    50                  55                  60                  


Leu Leu Glu Val Ser Gln His Ile Lys Met Arg Met Gly Gly Arg Val 
65                  70                  75                  80  


Asp Phe Glu Glu Phe Val Glu Leu Ile Gly Pro Lys Leu Arg Glu Glu 
                85                  90                  95      


Xaa Ala His Met Leu Gly Val Arg Glu Leu Arg Ile Ala Phe Arg Glu 
            100                 105                 110         


Phe Asp Arg Asp Arg Asp Gly Arg Ile Xaa Val Ala Glu Leu Arg Glu 
        115                 120                 125             


Ala Val Pro Ala Leu Leu Gly Glu Pro Leu Ala Gly Pro Glu Leu Asp 
    130                 135                 140                 


Glu Met Leu Arg Glu Val Asp Leu Asn Gly Asp Gly Xaa Val Asp Phe 
145                 150                 155                 160 


Asp Glu Phe Val Met Met Leu Ser Arg His 
                165                 170 


<210> 4621
<211> 275
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<400> 4621
Met Xaa Xaa Glu Gln Ala Arg Gly Gln Gln Gly Pro Asn Leu Ala Ile 
1               5                   10                  15      


Gly Arg Gln Lys Pro Pro Ala Gly Val Val Xaa Pro Lys Ser Asp Ala 
            20                  25                  30          


Glu Glu Pro Pro Leu Xaa Arg Lys Arg Ser Lys Lys Glu Arg Gly Leu 
        35                  40                  45              


Arg Gly Ser Arg Lys Arg Xaa Gly Ser Ser Gly Glu Gln Xaa Gly Pro 
    50                  55                  60                  


Glu Ala Pro Gly Ser Ser Asn Asn Pro Pro Ser Xaa Gly Glu Gly Pro 
65                  70                  75                  80  


Ala Gly Ala Pro Pro Ala Ser Pro Gly Pro Ala Ser Ser Arg Gln Ser 
                85                  90                  95      


His Arg His Arg Pro Asp Ser Leu His Asp Ala Ala Gln Arg Xaa Tyr 
            100                 105                 110         


Gly Pro Leu Leu Asn Arg Val Phe Gly Lys Asp Arg Glu Leu Gly Pro 
        115                 120                 125             


Glu Glu Leu Asp Glu Leu Gln Ala Ala Phe Glu Glu Phe Asp Xaa Asp 
    130                 135                 140                 


Arg Asp Gly Tyr Ile Ser His Arg Glu Leu Gly Asp Cys Met Arg Xaa 
145                 150                 155                 160 


Leu Gly Tyr Met Pro Xaa Glu Met Glu Leu Leu Glu Val Ser Gln His 
                165                 170                 175     


Ile Lys Met Arg Met Gly Gly Arg Val Asp Phe Glu Glu Phe Val Glu 
            180                 185                 190         


Leu Ile Gly Pro Lys Leu Arg Glu Glu Xaa Ala His Met Leu Gly Val 
        195                 200                 205             


Arg Glu Leu Arg Ile Ala Phe Arg Glu Phe Asp Arg Asp Arg Asp Gly 
    210                 215                 220                 


Arg Ile Xaa Val Ala Glu Leu Arg Glu Ala Val Pro Ala Leu Leu Gly 
225                 230                 235                 240 


Glu Pro Leu Ala Gly Pro Glu Leu Asp Glu Met Leu Arg Glu Val Asp 
                245                 250                 255     


Leu Asn Gly Asp Gly Xaa Val Asp Phe Asp Glu Phe Val Met Met Leu 
            260                 265                 270         


Ser Arg His 
        275 


<210> 4622
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 4622
Met Xaa Xaa Glu Gln Ala Arg Gly Gln Gln Gly Pro Asn Leu Ala Ile 
1               5                   10                  15      


Gly Arg Gln Lys Pro Pro Ala Gly Val Val Xaa Pro Lys Ser Asp Ala 
            20                  25                  30          


Glu Glu Pro Pro Leu Xaa Arg Lys Arg Ser Lys Lys Glu Arg Gly Leu 
        35                  40                  45              


Arg Gly Ser Arg Lys Arg Xaa Gly Ser Ser Gly Glu Gln Xaa Gly Pro 
    50                  55                  60                  


Glu Ala Pro Gly Ser Ser Asn Asn Pro Pro Ser Xaa Gly Glu Gly Pro 
65                  70                  75                  80  


Ala Gly Ala Pro Pro Ala Ser Pro Gly Pro Ala Ser Ser Arg Gln Ser 
                85                  90                  95      


His Arg His Arg Pro Asp Ser Leu His Asp Ala Ala Gln Arg Xaa Tyr 
            100                 105                 110         


Gly Pro Leu Leu Asn Arg Val Phe Gly Lys Gly Met Lys Glu Glu Gly 
        115                 120                 125             


<210> 4623
<211> 173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<400> 4623
Met Gln Phe Pro Met Gly Pro Ala Cys Ile Phe Leu Arg Lys Gly Ile 
1               5                   10                  15      


Ala Glu Lys Gln Arg Glu Arg Pro Leu Gly Gln Asp Glu Ile Glu Glu 
            20                  25                  30          


Leu Arg Glu Ala Phe Leu Glu Phe Asp Lys Asp Arg Asp Gly Phe Ile 
        35                  40                  45              


Ser Cys Lys Asp Leu Gly Asn Leu Met Arg Xaa Met Gly Tyr Met Pro 
    50                  55                  60                  


Xaa Glu Met Glu Leu Ile Glu Leu Gly Gln Gln Ile Arg Met Asn Leu 
65                  70                  75                  80  


Gly Gly Arg Val Asp Phe Asp Asp Phe Val Glu Leu Met Xaa Pro Lys 
                85                  90                  95      


Leu Leu Ala Glu Xaa Ala Gly Met Ile Gly Val Gln Glu Met Arg Asp 
            100                 105                 110         


Ala Phe Lys Glu Phe Asp Xaa Asn Gly Asp Gly Glu Ile Xaa Leu Val 
        115                 120                 125             


Glu Leu Gln Gln Ala Met Gln Arg Leu Leu Gly Glu Arg Leu Xaa Pro 
    130                 135                 140                 


Arg Glu Ile Ser Glu Val Val Arg Glu Ala Asp Val Asn Gly Asp Gly 
145                 150                 155                 160 


Xaa Val Asp Phe Glu Glu Phe Val Lys Met Met Ser Arg 
                165                 170             


<210> 4624
<211> 459
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<400> 4624
Asp Phe Ala Ile Ser Ala Lys Pro Leu Xaa Arg His Met Pro Gln Asn 
1               5                   10                  15      


Lys Gln Ser Phe Gln Tyr Arg Met Trp Gln Phe Val Val Ser Pro Pro 
            20                  25                  30          


Phe Glu Tyr Xaa Ile Met Ala Met Ile Ala Leu Asn Xaa Ile Val Leu 
        35                  40                  45              


Met Met Lys Phe Tyr Gly Ala Ser Val Ala Tyr Glu Asn Ala Leu Arg 
    50                  55                  60                  


Val Phe Asn Ile Val Phe Xaa Ser Leu Phe Ser Leu Glu Cys Val Leu 
65                  70                  75                  80  


Lys Val Met Ala Phe Gly Ile Leu Asn Tyr Phe Arg Asp Ala Trp Asn 
                85                  90                  95      


Ile Phe Asp Phe Val Xaa Val Leu Gly Ser Ile Xaa Asp Ile Leu Val 
            100                 105                 110         


Xaa Glu Phe Gly Asn Pro Asn Asn Phe Ile Asn Leu Ser Phe Leu Arg 
        115                 120                 125             


Leu Phe Arg Ala Ala Arg Leu Ile Lys Leu Leu Arg Gln Gly Tyr Xaa 
    130                 135                 140                 


Ile Arg Ile Leu Leu Trp Xaa Phe Val Gln Ser Phe Lys Ala Leu Pro 
145                 150                 155                 160 


Tyr Val Cys Leu Leu Ile Ala Met Leu Phe Phe Ile Tyr Ala Ile Ile 
                165                 170                 175     


Gly Met Gln Val Phe Gly Asn Ile Gly Ile Asp Val Glu Asp Glu Asp 
            180                 185                 190         


Ser Asp Glu Asp Glu Phe Gln Ile Xaa Glu His Asn Asn Phe Arg Xaa 
        195                 200                 205             


Phe Phe Gln Ala Leu Met Leu Leu Phe Arg Ser Ala Xaa Gly Glu Ala 
    210                 215                 220                 


Trp His Asn Ile Met Leu Ser Cys Leu Ser Gly Lys Pro Cys Asp Lys 
225                 230                 235                 240 


Asn Ser Gly Ile Leu Xaa Arg Glu Cys Gly Asn Glu Phe Ala Tyr Phe 
                245                 250                 255     


Tyr Phe Val Ser Phe Ile Phe Leu Cys Ser Phe Leu Met Leu Asn Leu 
            260                 265                 270         


Phe Val Ala Val Ile Met Asp Asn Phe Glu Tyr Leu Xaa Arg Asp Ser 
        275                 280                 285             


Ser Ile Leu Gly Pro His His Leu Asp Glu Tyr Val Arg Val Trp Ala 
    290                 295                 300                 


Glu Tyr Asp Pro Ala Ala Cys Gly Arg Ile His Tyr Lys Asp Met Tyr 
305                 310                 315                 320 


Ser Leu Leu Arg Val Ile Ser Pro Pro Leu Gly Leu Gly Lys Lys Cys 
                325                 330                 335     


Pro His Arg Val Ala Cys Lys Arg Leu Leu Arg Met Asp Leu Pro Val 
            340                 345                 350         


Ala Asp Asp Asn Xaa Val His Phe Asn Ser Xaa Leu Met Ala Leu Ile 
        355                 360                 365             


Arg Xaa Ala Leu Asp Ile Lys Ile Ala Lys Gly Gly Ala Asp Lys Gln 
    370                 375                 380                 


Gln Met Asp Ala Glu Leu Arg Lys Glu Met Met Ala Ile Trp Pro Asn 
385                 390                 395                 400 


Leu Ser Gln Lys Xaa Leu Asp Leu Leu Val Xaa Pro His Lys Ser Xaa 
                405                 410                 415     


Asp Leu Xaa Val Gly Lys Ile Tyr Ala Ala Met Met Ile Met Glu Tyr 
            420                 425                 430         


Tyr Arg Gln Ser Lys Ala Lys Lys Leu Gln Ala Met Arg Glu Glu Gln 
        435                 440                 445             


Asp Arg Xaa Pro Leu Met Phe Gln Arg Met Glu 
    450                 455                 


<210> 4625
<211> 212
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<400> 4625
Leu Leu Xaa Leu Phe Xaa Val Ser Xaa Gly Glu Gly Trp Pro Gln Val 
1               5                   10                  15      


Leu Lys His Ser Val Asp Ala Xaa Phe Glu Asn Gln Gly Pro Ser Pro 
            20                  25                  30          


Gly Tyr Arg Met Glu Met Ser Ile Phe Tyr Val Val Tyr Phe Val Val 
        35                  40                  45              


Phe Pro Phe Phe Phe Val Asn Ile Phe Val Ala Leu Ile Ile Ile Xaa 
    50                  55                  60                  


Phe Gln Glu Gln Gly Asp Lys Met Met Glu Glu Tyr Ser Leu Glu Lys 
65                  70                  75                  80  


Asn Glu Asn Asn Phe Ile Asn Leu Ser Phe Leu Arg Leu Phe Arg Ala 
                85                  90                  95      


Ala Arg Leu Ile Lys Leu Leu Arg Gln Gly Tyr Xaa Ile Arg Ile Leu 
            100                 105                 110         


Leu Trp Xaa Phe Val Gln Ser Phe Lys Ala Leu Pro Tyr Val Cys Leu 
        115                 120                 125             


Leu Ile Ala Met Leu Phe Phe Ile Tyr Ala Ile Ile Gly Met Gln Val 
    130                 135                 140                 


Phe Gly Asn Ile Gly Ile Asp Val Glu Asp Glu Asp Ser Asp Glu Asp 
145                 150                 155                 160 


Glu Phe Gln Ile Xaa Glu His Asn Asn Phe Arg Xaa Phe Phe Gln Ala 
                165                 170                 175     


Leu Met Leu Leu Phe Arg Ser Ala Xaa Gly Glu Ala Trp His Asn Ile 
            180                 185                 190         


Met Leu Ser Cys Leu Ser Gly Lys Pro Cys Asp Lys Asn Ser Gly Ile 
        195                 200                 205             


Leu Xaa Arg Glu 
    210         


<210> 4626
<211> 2460
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1093)..(1093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1106)..(1106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1108)..(1108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1120)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1238)..(1238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1294)..(1294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1360)..(1360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1405)..(1405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1411)..(1411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1426)..(1426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1466)..(1466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1498)..(1498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1524)..(1524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1533)..(1533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1559)..(1559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1590)..(1590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1601)..(1601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1630)..(1630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1637)..(1637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1687)..(1687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1694)..(1694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1707)..(1707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1732)..(1732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1771)..(1771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1843)..(1843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1849)..(1849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1856)..(1856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1891)..(1891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1897)..(1897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1902)..(1902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1905)..(1905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1937)..(1937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1950)..(1950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1963)..(1963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1986)..(1986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1996)..(1996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1998)..(1998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2007)..(2007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2068)..(2068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2072)..(2072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2125)..(2125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2129)..(2129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2133)..(2133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2138)..(2139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2227)..(2227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2230)..(2230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2232)..(2232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2243)..(2243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2246)..(2246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2289)..(2289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2299)..(2299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2310)..(2310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2402)..(2402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2408)..(2408)
<223> Selenocysteine

<400> 4626
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Xaa Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Xaa Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Asp Asp Xaa Glu Pro Tyr Phe Ile Gly Ile 
                85                  90                  95      


Phe Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe 
            100                 105                 110         


His Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val 
        115                 120                 125             


Val Val Leu Xaa Gly Ile Leu Ala Xaa Val Gly Xaa Glu Phe Asp Leu 
    130                 135                 140                 


Arg Xaa Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser 
145                 150                 155                 160 


Gly Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met 
                165                 170                 175     


Ile Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile 
            180                 185                 190         


Phe Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Xaa Xaa 
        195                 200                 205             


Cys Phe Glu Glu Gly Xaa Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro 
    210                 215                 220                 


Cys Gly Xaa Glu Glu Pro Ala Arg Xaa Cys Pro Asn Gly Xaa Lys Cys 
225                 230                 235                 240 


Gln Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Xaa Gln Phe Asp Asn 
                245                 250                 255     


Ile Leu Phe Ala Val Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly 
            260                 265                 270         


Trp Xaa Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Xaa Trp 
        275                 280                 285             


Asn Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met 
    290                 295                 300                 


Leu Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg 
305                 310                 315                 320 


Glu Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln 
                325                 330                 335     


Gln Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala 
            340                 345                 350         


Glu Glu Val Ile Leu Ala Glu Asp Glu Xaa Asp Gly Glu Gln Arg His 
        355                 360                 365             


Pro Phe Asp Gly Ala Leu Arg Arg Xaa Xaa Ile Lys Lys Ser Lys Xaa 
    370                 375                 380                 


Asp Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala 
385                 390                 395                 400 


Ser Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu 
                405                 410                 415     


Glu Asn Ser Xaa Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr 
            420                 425                 430         


Ile Arg Arg Met Val Lys Xaa Gln Ala Phe Tyr Trp Xaa Val Leu Ser 
        435                 440                 445             


Leu Val Ala Leu Asn Xaa Leu Cys Val Ala Ile Val His Tyr Asn Gln 
    450                 455                 460                 


Pro Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu 
465                 470                 475                 480 


Gly Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Xaa 
                485                 490                 495     


Arg Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile 
            500                 505                 510         


Ile Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Xaa 
        515                 520                 525             


Ser Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe 
    530                 535                 540                 


Lys Val Xaa Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu 
545                 550                 555                 560 


Leu Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu 
                565                 570                 575     


Phe Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln 
            580                 585                 590         


Phe Asn Phe Asp Glu Gly Xaa Pro Pro Xaa Asn Phe Asp Xaa Phe Pro 
        595                 600                 605             


Ala Ala Ile Met Xaa Val Phe Gln Ile Leu Xaa Gly Glu Asp Trp Asn 
    610                 615                 620                 


Glu Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly 
625                 630                 635                 640 


Met Val Phe Ser Ile Tyr Phe Ile Val Leu Xaa Leu Phe Gly Asn Tyr 
                645                 650                 655     


Xaa Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn 
            660                 665                 670         


Ala Gln Glu Leu Xaa Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn 
        675                 680                 685             


Gln Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro 
    690                 695                 700                 


Leu Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn 
705                 710                 715                 720 


Gln Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Xaa Ser Glu Met Arg 
                725                 730                 735     


Lys Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp 
            740                 745                 750         


Pro Asp Glu Arg Trp Lys Ala Ala Tyr Xaa Arg His Leu Arg Pro Asp 
        755                 760                 765             


Met Lys Xaa His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn 
    770                 775                 780                 


Arg Asn Asn Asn Xaa Asn Lys Ser Arg Ala Ala Glu Pro Xaa Val Asp 
785                 790                 795                 800 


Gln Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala 
                805                 810                 815     


Arg Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp 
            820                 825                 830         


Ala Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu 
        835                 840                 845             


Gly Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu 
    850                 855                 860                 


Glu Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly 
865                 870                 875                 880 


Asp Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser 
                885                 890                 895     


Arg Ser Gly Ser Pro Arg Xaa Gly Ala Asp Gly Glu His Arg Arg His 
            900                 905                 910         


Arg Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu 
        915                 920                 925             


Arg Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu 
    930                 935                 940                 


Gly Glu Gly Glu Gly Pro Asp Gly Gly Glu Arg Arg Arg Arg His Arg 
945                 950                 955                 960 


His Gly Ala Pro Ala Xaa Tyr Glu Gly Asp Ala Arg Arg Glu Asp Lys 
                965                 970                 975     


Glu Arg Arg His Arg Arg Arg Lys Glu Asn Gln Gly Ser Gly Val Pro 
            980                 985                 990         


Val Ser Gly Pro Asn Leu Ser Xaa  Xaa Arg Pro Ile Gln  Gln Asp Leu 
        995                 1000                 1005             


Gly Arg  Gln Asp Pro Pro Leu  Ala Glu Asp Ile Asp  Asn Met Lys 
    1010                 1015                 1020             


Asn Asn  Lys Leu Ala Xaa Ala  Glu Ser Ala Ala Pro  His Gly Ser 
    1025                 1030                 1035             


Leu Gly  His Ala Gly Leu Pro  Gln Ser Pro Ala Lys  Met Gly Asn 
    1040                 1045                 1050             


Ser Xaa  Asp Pro Gly Pro Met  Leu Ala Ile Pro Ala  Met Ala Xaa 
    1055                 1060                 1065             


Asn Pro  Gln Asn Ala Ala Ser  Arg Arg Xaa Pro Asn  Asn Pro Gly 
    1070                 1075                 1080             


Asn Pro  Ser Asn Pro Gly Pro  Pro Lys Xaa Pro Glu  Asn Ser Leu 
    1085                 1090                 1095             


Ile Val  Xaa Asn Pro Ser Gly  Xaa Gln Xaa Asn Ser  Ala Lys Xaa 
    1100                 1105                 1110             


Ala Arg  Lys Pro Asp His Xaa  Xaa Val Asp Ile Pro  Pro Ala Cys 
    1115                 1120                 1125             


Pro Pro  Pro Leu Asn His Xaa  Val Val Gln Val Asn  Lys Asn Ala 
    1130                 1135                 1140             


Asn Pro  Asp Pro Leu Pro Lys  Lys Glu Glu Glu Lys  Lys Glu Glu 
    1145                 1150                 1155             


Glu Glu  Asp Asp Arg Gly Glu  Asp Gly Pro Lys Pro  Met Pro Pro 
    1160                 1165                 1170             


Tyr Ser  Ser Met Phe Ile Leu  Ser Xaa Xaa Asn Pro  Leu Arg Arg 
    1175                 1180                 1185             


Leu Cys  His Tyr Ile Leu Asn  Leu Arg Tyr Phe Glu  Met Cys Ile 
    1190                 1195                 1200             


Leu Met  Val Ile Ala Met Ser  Ser Ile Ala Leu Ala  Ala Glu Asp 
    1205                 1210                 1215             


Pro Val  Gln Pro Asn Ala Pro  Arg Asn Asn Val Leu  Arg Tyr Phe 
    1220                 1225                 1230             


Asp Tyr  Val Phe Xaa Gly Val  Phe Xaa Phe Glu Met  Val Ile Lys 
    1235                 1240                 1245             


Met Ile  Asp Leu Gly Leu Val  Leu His Gln Gly Ala  Tyr Phe Arg 
    1250                 1255                 1260             


Asp Leu  Trp Asn Ile Leu Asp  Phe Ile Val Val Ser  Gly Ala Leu 
    1265                 1270                 1275             


Val Ala  Phe Ala Phe Xaa Gly  Asn Ser Lys Gly Lys  Asp Ile Asn 
    1280                 1285                 1290             


Xaa Ile  Lys Ser Leu Arg Val  Leu Arg Val Leu Arg  Pro Leu Lys 
    1295                 1300                 1305             


Xaa Ile  Lys Arg Leu Pro Lys  Leu Lys Ala Val Phe  Asp Cys Val 
    1310                 1315                 1320             


Val Asn  Ser Leu Lys Asn Val  Phe Asn Ile Leu Ile  Val Tyr Met 
    1325                 1330                 1335             


Leu Phe  Met Phe Ile Phe Ala  Val Val Ala Val Gln  Leu Phe Lys 
    1340                 1345                 1350             


Gly Lys  Phe Phe His Cys Xaa  Asp Glu Ser Lys Glu  Phe Glu Lys 
    1355                 1360                 1365             


Asp Cys  Arg Gly Lys Tyr Leu  Leu Tyr Glu Lys Asn  Glu Val Lys 
    1370                 1375                 1380             


Ala Arg  Asp Arg Glu Trp Lys  Lys Tyr Glu Phe His  Tyr Asp Asn 
    1385                 1390                 1395             


Val Leu  Trp Ala Leu Leu Xaa  Leu Phe Xaa Val Ser  Xaa Gly Glu 
    1400                 1405                 1410             


Gly Trp  Pro Gln Val Leu Lys  His Ser Val Asp Ala  Xaa Phe Glu 
    1415                 1420                 1425             


Asn Gln  Gly Pro Ser Pro Gly  Tyr Arg Met Glu Met  Ser Ile Phe 
    1430                 1435                 1440             


Tyr Val  Val Tyr Phe Val Val  Phe Pro Phe Phe Phe  Val Asn Ile 
    1445                 1450                 1455             


Phe Val  Ala Leu Ile Ile Ile  Xaa Phe Gln Glu Gln  Gly Asp Lys 
    1460                 1465                 1470             


Met Met  Glu Glu Tyr Ser Leu  Glu Lys Asn Glu Arg  Ala Cys Ile 
    1475                 1480                 1485             


Asp Phe  Ala Ile Ser Ala Lys  Pro Leu Xaa Arg His  Met Pro Gln 
    1490                 1495                 1500             


Asn Lys  Gln Ser Phe Gln Tyr  Arg Met Trp Gln Phe  Val Val Ser 
    1505                 1510                 1515             


Pro Pro  Phe Glu Tyr Xaa Ile  Met Ala Met Ile Ala  Leu Asn Xaa 
    1520                 1525                 1530             


Ile Val  Leu Met Met Lys Phe  Tyr Gly Ala Ser Val  Ala Tyr Glu 
    1535                 1540                 1545             


Asn Ala  Leu Arg Val Phe Asn  Ile Val Phe Xaa Ser  Leu Phe Ser 
    1550                 1555                 1560             


Leu Glu  Cys Val Leu Lys Val  Met Ala Phe Gly Ile  Leu Asn Tyr 
    1565                 1570                 1575             


Phe Arg  Asp Ala Trp Asn Ile  Phe Asp Phe Val Xaa  Val Leu Gly 
    1580                 1585                 1590             


Ser Ile  Xaa Asp Ile Leu Val  Xaa Glu Phe Gly Asn  Asn Phe Ile 
    1595                 1600                 1605             


Asn Leu  Ser Phe Leu Arg Leu  Phe Arg Ala Ala Arg  Leu Ile Lys 
    1610                 1615                 1620             


Leu Leu  Arg Gln Gly Tyr Xaa  Ile Arg Ile Leu Leu  Trp Xaa Phe 
    1625                 1630                 1635             


Val Gln  Ser Phe Lys Ala Leu  Pro Tyr Val Cys Leu  Leu Ile Ala 
    1640                 1645                 1650             


Met Leu  Phe Phe Ile Tyr Ala  Ile Ile Gly Met Gln  Val Phe Gly 
    1655                 1660                 1665             


Asn Ile  Gly Ile Asp Val Glu  Asp Glu Asp Ser Asp  Glu Asp Glu 
    1670                 1675                 1680             


Phe Gln  Ile Xaa Glu His Asn  Asn Phe Arg Xaa Phe  Phe Gln Ala 
    1685                 1690                 1695             


Leu Met  Leu Leu Phe Arg Ser  Ala Xaa Gly Glu Ala  Trp His Asn 
    1700                 1705                 1710             


Ile Met  Leu Ser Cys Leu Ser  Gly Lys Pro Cys Asp  Lys Asn Ser 
    1715                 1720                 1725             


Gly Ile  Leu Xaa Arg Glu Cys  Gly Asn Glu Phe Ala  Tyr Phe Tyr 
    1730                 1735                 1740             


Phe Val  Ser Phe Ile Phe Leu  Cys Ser Phe Leu Met  Leu Asn Leu 
    1745                 1750                 1755             


Phe Val  Ala Val Ile Met Asp  Asn Phe Glu Tyr Leu  Xaa Arg Asp 
    1760                 1765                 1770             


Ser Ser  Ile Leu Gly Pro His  His Leu Asp Glu Tyr  Val Arg Val 
    1775                 1780                 1785             


Trp Ala  Glu Tyr Asp Pro Ala  Ala Cys Gly Arg Ile  His Tyr Lys 
    1790                 1795                 1800             


Asp Met  Tyr Ser Leu Leu Arg  Val Ile Ser Pro Pro  Leu Gly Leu 
    1805                 1810                 1815             


Gly Lys  Lys Cys Pro His Arg  Val Ala Cys Lys Arg  Leu Leu Arg 
    1820                 1825                 1830             


Met Asp  Leu Pro Val Ala Asp  Asp Asn Xaa Val His  Phe Asn Ser 
    1835                 1840                 1845             


Xaa Leu  Met Ala Leu Ile Arg  Xaa Ala Leu Asp Ile  Lys Ile Ala 
    1850                 1855                 1860             


Lys Gly  Gly Ala Asp Lys Gln  Gln Met Asp Ala Glu  Leu Arg Lys 
    1865                 1870                 1875             


Glu Met  Met Ala Ile Trp Pro  Asn Leu Ser Gln Lys  Xaa Leu Asp 
    1880                 1885                 1890             


Leu Leu  Val Xaa Pro His Lys  Ser Xaa Asp Leu Xaa  Val Gly Lys 
    1895                 1900                 1905             


Ile Tyr  Ala Ala Met Met Ile  Met Glu Tyr Tyr Arg  Gln Ser Lys 
    1910                 1915                 1920             


Ala Lys  Lys Leu Gln Ala Met  Arg Glu Glu Gln Asp  Arg Xaa Pro 
    1925                 1930                 1935             


Leu Met  Phe Gln Arg Met Glu  Pro Pro Ser Pro Xaa  Gln Glu Gly 
    1940                 1945                 1950             


Gly Pro  Gly Gln Asn Ala Leu  Pro Ser Xaa Gln Leu  Asp Pro Gly 
    1955                 1960                 1965             


Gly Ala  Leu Met Ala His Glu  Ser Gly Leu Lys Glu  Ser Pro Ser 
    1970                 1975                 1980             


Trp Val  Xaa Gln Arg Ala Gln  Glu Met Phe Gln Lys  Xaa Gly Xaa 
    1985                 1990                 1995             


Trp Ser  Pro Glu Gln Gly Pro  Pro Xaa Asp Met Pro  Asn Ser Gln 
    2000                 2005                 2010             


Pro Asn  Ser Gln Ser Val Glu  Met Arg Glu Met Gly  Arg Asp Gly 
    2015                 2020                 2025             


Tyr Ser  Asp Ser Glu His Tyr  Leu Pro Met Glu Gly  Gln Gly Arg 
    2030                 2035                 2040             


Ala Ala  Ser Met Pro Arg Leu  Pro Ala Glu Asn Gln  Arg Arg Arg 
    2045                 2050                 2055             


Gly Arg  Pro Arg Gly Asn Asn  Leu Ser Xaa Ile Ser  Asp Xaa Ser 
    2060                 2065                 2070             


Pro Met  Lys Arg Ser Ala Ser  Val Leu Gly Pro Lys  Ala Arg Arg 
    2075                 2080                 2085             


Leu Asp  Asp Tyr Ser Leu Glu  Arg Val Pro Pro Glu  Glu Asn Gln 
    2090                 2095                 2100             


Arg His  His Gln Arg Arg Arg  Asp Arg Ser His Arg  Ala Ser Glu 
    2105                 2110                 2115             


Arg Ser  Leu Gly Arg Tyr Xaa  Asp Val Asp Xaa Gly  Leu Gly Xaa 
    2120                 2125                 2130             


Asp Leu  Ser Met Xaa Xaa Gln  Ser Gly Asp Leu Pro  Ser Lys Glu 
    2135                 2140                 2145             


Arg Asp  Gln Glu Arg Gly Arg  Pro Lys Asp Arg Lys  His Arg Gln 
    2150                 2155                 2160             


His His  His His His His His  His His His Pro Pro  Pro Pro Asp 
    2165                 2170                 2175             


Lys Asp  Arg Tyr Ala Gln Glu  Arg Pro Asp His Gly  Arg Ala Arg 
    2180                 2185                 2190             


Ala Arg  Asp Gln Arg Trp Ser  Arg Ser Pro Ser Glu  Gly Arg Glu 
    2195                 2200                 2205             


His Met  Ala His Arg Gln Gly  Ser Ser Ser Val Ser  Gly Ser Pro 
    2210                 2215                 2220             


Ala Pro  Ser Xaa Ser Gly Xaa  Ser Xaa Pro Arg Arg  Gly Arg Arg 
    2225                 2230                 2235             


Gln Leu  Pro Gln Xaa Pro Ser  Xaa Pro Arg Pro His  Val Ser Tyr 
    2240                 2245                 2250             


Ser Pro  Val Ile Arg Lys Ala  Gly Gly Ser Gly Pro  Pro Gln Gln 
    2255                 2260                 2265             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Ala  Val Ala Arg 
    2270                 2275                 2280             


Pro Gly  Arg Ala Ala Xaa Ser  Gly Pro Arg Arg Tyr  Pro Gly Pro 
    2285                 2290                 2295             


Xaa Ala  Glu Pro Leu Ala Gly  Asp Arg Pro Pro Xaa  Gly Gly His 
    2300                 2305                 2310             


Ser Ser  Gly Arg Ser Pro Arg  Met Glu Arg Arg Val  Pro Gly Pro 
    2315                 2320                 2325             


Ala Arg  Ser Glu Ser Pro Arg  Ala Cys Arg His Gly  Gly Ala Arg 
    2330                 2335                 2340             


Trp Pro  Ala Ser Gly Pro His  Val Ser Glu Gly Pro  Pro Gly Pro 
    2345                 2350                 2355             


Arg His  His Gly Tyr Tyr Arg  Gly Ser Asp Tyr Asp  Glu Ala Asp 
    2360                 2365                 2370             


Gly Pro  Gly Ser Gly Gly Gly  Glu Glu Ala Met Ala  Gly Ala Tyr 
    2375                 2380                 2385             


Asp Ala  Pro Pro Pro Val Arg  His Ala Ser Ser Gly  Ala Xaa Gly 
    2390                 2395                 2400             


Arg Ser  Pro Arg Xaa Pro Arg  Ala Ser Gly Pro Ala  Cys Ala Ser 
    2405                 2410                 2415             


Pro Ser  Arg His Gly Arg Arg  Leu Pro Asn Gly Tyr  Tyr Pro Ala 
    2420                 2425                 2430             


His Gly  Leu Ala Arg Pro Arg  Gly Pro Gly Ser Arg  Lys Gly Leu 
    2435                 2440                 2445             


His Glu  Pro Tyr Ser Glu Ser  Asp Asp Asp Trp Cys  
    2450                 2455                 2460 


<210> 4627
<211> 2249
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1356)..(1356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1452)..(1452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1571)..(1571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1580)..(1580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1637)..(1637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1643)..(1643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1648)..(1648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1677)..(1677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1684)..(1684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1734)..(1734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1741)..(1741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1779)..(1779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1818)..(1818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1890)..(1890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1896)..(1896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1903)..(1903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1938)..(1938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1944)..(1944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1949)..(1949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1952)..(1952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1984)..(1984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1997)..(1997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2010)..(2010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2033)..(2033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2043)..(2043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2045)..(2045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2054)..(2054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2103)..(2103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2107)..(2107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2160)..(2160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2164)..(2164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2168)..(2168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2173)..(2174)
<223> Selenocysteine

<400> 4627
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Xaa Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Xaa Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Xaa Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Xaa Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Xaa Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Xaa Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Xaa Gly Ile Leu Ala Xaa Val Gly Xaa Glu Phe Asp Leu Arg 
            180                 185                 190         


Xaa Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Xaa Xaa Cys 
                245                 250                 255     


Phe Glu Glu Gly Xaa Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Xaa Glu Glu Pro Ala Arg Xaa Cys Pro Asn Gly Xaa Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Xaa Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp 
305                 310                 315                 320 


Xaa Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Xaa Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Xaa Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Gly Ala Leu Arg Arg Xaa Xaa Ile Lys Lys Ser Lys Xaa Asp 
            420                 425                 430         


Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser 
        435                 440                 445             


Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu 
    450                 455                 460                 


Asn Ser Xaa Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile 
465                 470                 475                 480 


Arg Arg Met Val Lys Xaa Gln Ala Phe Tyr Trp Xaa Val Leu Ser Leu 
                485                 490                 495     


Val Ala Leu Asn Xaa Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro 
            500                 505                 510         


Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly 
        515                 520                 525             


Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Xaa Arg 
    530                 535                 540                 


Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile 
545                 550                 555                 560 


Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Xaa Ser 
                565                 570                 575     


Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys 
            580                 585                 590         


Val Xaa Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu 
        595                 600                 605             


Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe 
    610                 615                 620                 


Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe 
625                 630                 635                 640 


Asn Phe Asp Glu Gly Xaa Pro Pro Xaa Asn Phe Asp Xaa Phe Pro Ala 
                645                 650                 655     


Ala Ile Met Xaa Val Phe Gln Ile Leu Xaa Gly Glu Asp Trp Asn Glu 
            660                 665                 670         


Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met 
        675                 680                 685             


Val Phe Ser Ile Tyr Phe Ile Val Leu Xaa Leu Phe Gly Asn Tyr Xaa 
    690                 695                 700                 


Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala 
705                 710                 715                 720 


Gln Glu Leu Xaa Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln 
                725                 730                 735     


Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu 
            740                 745                 750         


Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln 
        755                 760                 765             


Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Xaa Ser Glu Met Arg Lys 
    770                 775                 780                 


Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro 
785                 790                 795                 800 


Asp Glu Arg Trp Lys Ala Ala Tyr Xaa Arg His Leu Arg Pro Asp Met 
                805                 810                 815     


Lys Xaa His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg 
            820                 825                 830         


Asn Asn Asn Xaa Asn Lys Ser Arg Ala Ala Glu Pro Xaa Val Asp Gln 
        835                 840                 845             


Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg 
    850                 855                 860                 


Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala 
865                 870                 875                 880 


Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly 
                885                 890                 895     


Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu 
            900                 905                 910         


Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp 
        915                 920                 925             


Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg 
    930                 935                 940                 


Ser Gly Ser Pro Arg Xaa Gly Ala Asp Gly Glu His Arg Arg His Arg 
945                 950                 955                 960 


Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg 
                965                 970                 975     


Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly 
            980                 985                 990         


Glu Gly Glu Gly Pro Asp Gly Gly  Glu Arg Arg Arg Arg  His Arg His 
        995                 1000                 1005             


Gly Ala  Pro Ala Xaa Tyr Glu  Gly Asp Ala Arg Arg  Glu Asp Lys 
    1010                 1015                 1020             


Glu Arg  Arg His Arg Arg Arg  Lys Glu Asn Gln Gly  Ser Gly Val 
    1025                 1030                 1035             


Pro Val  Ser Gly Pro Asn Leu  Ser Xaa Xaa Arg Pro  Ile Gln Gln 
    1040                 1045                 1050             


Asp Leu  Gly Arg Gln Asp Pro  Pro Leu Ala Glu Asp  Ile Asp Asn 
    1055                 1060                 1065             


Met Lys  Asn Asn Lys Leu Ala  Xaa Ala Glu Ser Ala  Ala Pro His 
    1070                 1075                 1080             


Gly Ser  Leu Gly His Ala Gly  Leu Pro Gln Ser Pro  Ala Lys Met 
    1085                 1090                 1095             


Gly Asn  Ser Xaa Asp Pro Gly  Pro Met Leu Ala Ile  Pro Ala Met 
    1100                 1105                 1110             


Ala Xaa  Asn Pro Gln Asn Ala  Ala Ser Arg Arg Xaa  Pro Asn Asn 
    1115                 1120                 1125             


Pro Gly  Asn Pro Ser Asn Pro  Gly Pro Pro Lys Xaa  Pro Glu Asn 
    1130                 1135                 1140             


Ser Leu  Ile Val Xaa Asn Pro  Ser Gly Xaa Gln Xaa  Asn Ser Ala 
    1145                 1150                 1155             


Lys Xaa  Ala Arg Lys Pro Asp  His Xaa Xaa Val Asp  Ile Pro Pro 
    1160                 1165                 1170             


Ala Cys  Pro Pro Pro Leu Asn  His Xaa Val Val Gln  Val Asn Lys 
    1175                 1180                 1185             


Asn Ala  Asn Pro Asp Pro Leu  Pro Lys Lys Glu Glu  Glu Lys Lys 
    1190                 1195                 1200             


Glu Glu  Glu Glu Asp Asp Arg  Gly Glu Asp Gly Pro  Lys Pro Met 
    1205                 1210                 1215             


Pro Pro  Tyr Ser Ser Met Phe  Ile Leu Ser Xaa Xaa  Asn Pro Leu 
    1220                 1225                 1230             


Arg Arg  Leu Cys His Tyr Ile  Leu Asn Leu Arg Tyr  Phe Glu Met 
    1235                 1240                 1245             


Cys Ile  Leu Met Val Ile Ala  Met Ser Ser Ile Ala  Leu Ala Ala 
    1250                 1255                 1260             


Glu Asp  Pro Val Gln Pro Asn  Ala Pro Arg Asn Asn  Val Leu Arg 
    1265                 1270                 1275             


Tyr Phe  Asp Tyr Val Phe Xaa  Gly Val Phe Xaa Phe  Glu Met Val 
    1280                 1285                 1290             


Ile Lys  Met Ile Asp Leu Gly  Leu Val Leu His Gln  Gly Ala Tyr 
    1295                 1300                 1305             


Phe Arg  Asp Leu Trp Asn Ile  Leu Asp Phe Ile Val  Val Ser Gly 
    1310                 1315                 1320             


Ala Leu  Val Ala Phe Ala Phe  Xaa Gly Asn Ser Lys  Gly Lys Asp 
    1325                 1330                 1335             


Ile Asn  Xaa Ile Lys Ser Leu  Arg Val Leu Arg Val  Leu Arg Pro 
    1340                 1345                 1350             


Leu Lys  Xaa Ile Lys Arg Leu  Pro Lys Leu Lys Ala  Val Phe Asp 
    1355                 1360                 1365             


Cys Val  Val Asn Ser Leu Lys  Asn Val Phe Asn Ile  Leu Ile Val 
    1370                 1375                 1380             


Tyr Met  Leu Phe Met Phe Ile  Phe Ala Val Val Ala  Val Gln Leu 
    1385                 1390                 1395             


Phe Lys  Gly Lys Phe Phe His  Cys Xaa Asp Glu Ser  Lys Glu Phe 
    1400                 1405                 1410             


Glu Lys  Asp Cys Arg Gly Lys  Tyr Leu Leu Tyr Glu  Lys Asn Glu 
    1415                 1420                 1425             


Val Lys  Ala Arg Asp Arg Glu  Trp Lys Lys Tyr Glu  Phe His Tyr 
    1430                 1435                 1440             


Asp Asn  Val Leu Trp Ala Leu  Leu Xaa Leu Phe Xaa  Val Ser Xaa 
    1445                 1450                 1455             


Gly Glu  Gly Trp Pro Gln Val  Leu Lys His Ser Val  Asp Ala Xaa 
    1460                 1465                 1470             


Phe Glu  Asn Gln Gly Pro Ser  Pro Gly Tyr Arg Met  Glu Met Ser 
    1475                 1480                 1485             


Ile Phe  Tyr Val Val Tyr Phe  Val Val Phe Pro Phe  Phe Phe Val 
    1490                 1495                 1500             


Asn Ile  Phe Val Ala Leu Ile  Ile Ile Xaa Phe Gln  Glu Gln Gly 
    1505                 1510                 1515             


Asp Lys  Met Met Glu Glu Tyr  Ser Leu Glu Lys Asn  Glu Arg Ala 
    1520                 1525                 1530             


Cys Ile  Asp Phe Ala Ile Ser  Ala Lys Pro Leu Xaa  Arg His Met 
    1535                 1540                 1545             


Pro Gln  Asn Lys Gln Ser Phe  Gln Tyr Arg Met Trp  Gln Phe Val 
    1550                 1555                 1560             


Val Ser  Pro Pro Phe Glu Tyr  Xaa Ile Met Ala Met  Ile Ala Leu 
    1565                 1570                 1575             


Asn Xaa  Ile Val Leu Met Met  Lys Phe Tyr Gly Ala  Ser Val Ala 
    1580                 1585                 1590             


Tyr Glu  Asn Ala Leu Arg Val  Phe Asn Ile Val Phe  Xaa Ser Leu 
    1595                 1600                 1605             


Phe Ser  Leu Glu Cys Val Leu  Lys Val Met Ala Phe  Gly Ile Leu 
    1610                 1615                 1620             


Asn Tyr  Phe Arg Asp Ala Trp  Asn Ile Phe Asp Phe  Val Xaa Val 
    1625                 1630                 1635             


Leu Gly  Ser Ile Xaa Asp Ile  Leu Val Xaa Glu Phe  Gly Asn Asn 
    1640                 1645                 1650             


Phe Ile  Asn Leu Ser Phe Leu  Arg Leu Phe Arg Ala  Ala Arg Leu 
    1655                 1660                 1665             


Ile Lys  Leu Leu Arg Gln Gly  Tyr Xaa Ile Arg Ile  Leu Leu Trp 
    1670                 1675                 1680             


Xaa Phe  Val Gln Ser Phe Lys  Ala Leu Pro Tyr Val  Cys Leu Leu 
    1685                 1690                 1695             


Ile Ala  Met Leu Phe Phe Ile  Tyr Ala Ile Ile Gly  Met Gln Val 
    1700                 1705                 1710             


Phe Gly  Asn Ile Gly Ile Asp  Val Glu Asp Glu Asp  Ser Asp Glu 
    1715                 1720                 1725             


Asp Glu  Phe Gln Ile Xaa Glu  His Asn Asn Phe Arg  Xaa Phe Phe 
    1730                 1735                 1740             


Gln Ala  Leu Met Leu Leu Phe  Arg Ser Ala Xaa Gly  Glu Ala Trp 
    1745                 1750                 1755             


His Asn  Ile Met Leu Ser Cys  Leu Ser Gly Lys Pro  Cys Asp Lys 
    1760                 1765                 1770             


Asn Ser  Gly Ile Leu Xaa Arg  Glu Cys Gly Asn Glu  Phe Ala Tyr 
    1775                 1780                 1785             


Phe Tyr  Phe Val Ser Phe Ile  Phe Leu Cys Ser Phe  Leu Met Leu 
    1790                 1795                 1800             


Asn Leu  Phe Val Ala Val Ile  Met Asp Asn Phe Glu  Tyr Leu Xaa 
    1805                 1810                 1815             


Arg Asp  Ser Ser Ile Leu Gly  Pro His His Leu Asp  Glu Tyr Val 
    1820                 1825                 1830             


Arg Val  Trp Ala Glu Tyr Asp  Pro Ala Ala Trp Gly  Arg Met Pro 
    1835                 1840                 1845             


Tyr Leu  Asp Met Tyr Gln Met  Leu Arg His Met Ser  Pro Pro Leu 
    1850                 1855                 1860             


Gly Leu  Gly Lys Lys Cys Pro  Ala Arg Val Ala Tyr  Lys Arg Leu 
    1865                 1870                 1875             


Leu Arg  Met Asp Leu Pro Val  Ala Asp Asp Asn Xaa  Val His Phe 
    1880                 1885                 1890             


Asn Ser  Xaa Leu Met Ala Leu  Ile Arg Xaa Ala Leu  Asp Ile Lys 
    1895                 1900                 1905             


Ile Ala  Lys Gly Gly Ala Asp  Lys Gln Gln Met Asp  Ala Glu Leu 
    1910                 1915                 1920             


Arg Lys  Glu Met Met Ala Ile  Trp Pro Asn Leu Ser  Gln Lys Xaa 
    1925                 1930                 1935             


Leu Asp  Leu Leu Val Xaa Pro  His Lys Ser Xaa Asp  Leu Xaa Val 
    1940                 1945                 1950             


Gly Lys  Ile Tyr Ala Ala Met  Met Ile Met Glu Tyr  Tyr Arg Gln 
    1955                 1960                 1965             


Ser Lys  Ala Lys Lys Leu Gln  Ala Met Arg Glu Glu  Gln Asp Arg 
    1970                 1975                 1980             


Xaa Pro  Leu Met Phe Gln Arg  Met Glu Pro Pro Ser  Pro Xaa Gln 
    1985                 1990                 1995             


Glu Gly  Gly Pro Gly Gln Asn  Ala Leu Pro Ser Xaa  Gln Leu Asp 
    2000                 2005                 2010             


Pro Gly  Gly Ala Leu Met Ala  His Glu Ser Gly Leu  Lys Glu Ser 
    2015                 2020                 2025             


Pro Ser  Trp Val Xaa Gln Arg  Ala Gln Glu Met Phe  Gln Lys Xaa 
    2030                 2035                 2040             


Gly Xaa  Trp Ser Pro Glu Gln  Gly Pro Pro Xaa Asp  Met Pro Asn 
    2045                 2050                 2055             


Ser Gln  Pro Asn Ser Gln Ser  Val Glu Met Arg Glu  Met Gly Arg 
    2060                 2065                 2070             


Asp Gly  Tyr Ser Asp Ser Glu  His Tyr Leu Pro Met  Glu Gly Gln 
    2075                 2080                 2085             


Gly Arg  Ala Ala Ser Met Pro  Arg Leu Pro Ala Glu  Asn Gln Xaa 
    2090                 2095                 2100             


Ile Ser  Asp Xaa Ser Pro Met  Lys Arg Ser Ala Ser  Val Leu Gly 
    2105                 2110                 2115             


Pro Lys  Ala Arg Arg Leu Asp  Asp Tyr Ser Leu Glu  Arg Val Pro 
    2120                 2125                 2130             


Pro Glu  Glu Asn Gln Arg His  His Gln Arg Arg Arg  Asp Arg Ser 
    2135                 2140                 2145             


His Arg  Ala Ser Glu Arg Ser  Leu Gly Arg Tyr Xaa  Asp Val Asp 
    2150                 2155                 2160             


Xaa Gly  Leu Gly Xaa Asp Leu  Ser Met Xaa Xaa Gln  Ser Gly Asp 
    2165                 2170                 2175             


Leu Pro  Ser Lys Glu Arg Asp  Gln Glu Arg Gly Arg  Pro Lys Asp 
    2180                 2185                 2190             


Arg Lys  His Arg Gln His His  His His His His His  His His His 
    2195                 2200                 2205             


Pro Pro  Pro Pro Asp Lys Asp  Arg Tyr Ala Gln Glu  Arg Pro Asp 
    2210                 2215                 2220             


His Gly  Arg Ala Arg Ala Arg  Asp Gln Arg Trp Ser  Arg Ser Pro 
    2225                 2230                 2235             


Ser Glu  Gly Arg Glu His Met  Ala His Arg Gln 
    2240                 2245                 


<210> 4628
<211> 2261
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1356)..(1356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1452)..(1452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1571)..(1571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1580)..(1580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1637)..(1637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1643)..(1643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1648)..(1648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1677)..(1677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1684)..(1684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1734)..(1734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1741)..(1741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1779)..(1779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1818)..(1818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1890)..(1890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1896)..(1896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1903)..(1903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1938)..(1938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1944)..(1944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1949)..(1949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1952)..(1952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1984)..(1984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1997)..(1997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2010)..(2010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2033)..(2033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2043)..(2043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2045)..(2045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2054)..(2054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2115)..(2115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2119)..(2119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2172)..(2172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2176)..(2176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2180)..(2180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2185)..(2186)
<223> Selenocysteine

<400> 4628
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Xaa Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Xaa Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Xaa Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Xaa Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Xaa Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Xaa Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Xaa Gly Ile Leu Ala Xaa Val Gly Xaa Glu Phe Asp Leu Arg 
            180                 185                 190         


Xaa Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Xaa Xaa Cys 
                245                 250                 255     


Phe Glu Glu Gly Xaa Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Xaa Glu Glu Pro Ala Arg Xaa Cys Pro Asn Gly Xaa Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Xaa Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp 
305                 310                 315                 320 


Xaa Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Xaa Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Xaa Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Gly Ala Leu Arg Arg Xaa Xaa Ile Lys Lys Ser Lys Xaa Asp 
            420                 425                 430         


Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser 
        435                 440                 445             


Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu 
    450                 455                 460                 


Asn Ser Xaa Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile 
465                 470                 475                 480 


Arg Arg Met Val Lys Xaa Gln Ala Phe Tyr Trp Xaa Val Leu Ser Leu 
                485                 490                 495     


Val Ala Leu Asn Xaa Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro 
            500                 505                 510         


Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly 
        515                 520                 525             


Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Xaa Arg 
    530                 535                 540                 


Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile 
545                 550                 555                 560 


Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Xaa Ser 
                565                 570                 575     


Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys 
            580                 585                 590         


Val Xaa Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu 
        595                 600                 605             


Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe 
    610                 615                 620                 


Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe 
625                 630                 635                 640 


Asn Phe Asp Glu Gly Xaa Pro Pro Xaa Asn Phe Asp Xaa Phe Pro Ala 
                645                 650                 655     


Ala Ile Met Xaa Val Phe Gln Ile Leu Xaa Gly Glu Asp Trp Asn Glu 
            660                 665                 670         


Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met 
        675                 680                 685             


Val Phe Ser Ile Tyr Phe Ile Val Leu Xaa Leu Phe Gly Asn Tyr Xaa 
    690                 695                 700                 


Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala 
705                 710                 715                 720 


Gln Glu Leu Xaa Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln 
                725                 730                 735     


Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu 
            740                 745                 750         


Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln 
        755                 760                 765             


Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Xaa Ser Glu Met Arg Lys 
    770                 775                 780                 


Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro 
785                 790                 795                 800 


Asp Glu Arg Trp Lys Ala Ala Tyr Xaa Arg His Leu Arg Pro Asp Met 
                805                 810                 815     


Lys Xaa His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg 
            820                 825                 830         


Asn Asn Asn Xaa Asn Lys Ser Arg Ala Ala Glu Pro Xaa Val Asp Gln 
        835                 840                 845             


Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg 
    850                 855                 860                 


Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala 
865                 870                 875                 880 


Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly 
                885                 890                 895     


Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu 
            900                 905                 910         


Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp 
        915                 920                 925             


Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg 
    930                 935                 940                 


Ser Gly Ser Pro Arg Xaa Gly Ala Asp Gly Glu His Arg Arg His Arg 
945                 950                 955                 960 


Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg 
                965                 970                 975     


Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly 
            980                 985                 990         


Glu Gly Glu Gly Pro Asp Gly Gly  Glu Arg Arg Arg Arg  His Arg His 
        995                 1000                 1005             


Gly Ala  Pro Ala Xaa Tyr Glu  Gly Asp Ala Arg Arg  Glu Asp Lys 
    1010                 1015                 1020             


Glu Arg  Arg His Arg Arg Arg  Lys Glu Asn Gln Gly  Ser Gly Val 
    1025                 1030                 1035             


Pro Val  Ser Gly Pro Asn Leu  Ser Xaa Xaa Arg Pro  Ile Gln Gln 
    1040                 1045                 1050             


Asp Leu  Gly Arg Gln Asp Pro  Pro Leu Ala Glu Asp  Ile Asp Asn 
    1055                 1060                 1065             


Met Lys  Asn Asn Lys Leu Ala  Xaa Ala Glu Ser Ala  Ala Pro His 
    1070                 1075                 1080             


Gly Ser  Leu Gly His Ala Gly  Leu Pro Gln Ser Pro  Ala Lys Met 
    1085                 1090                 1095             


Gly Asn  Ser Xaa Asp Pro Gly  Pro Met Leu Ala Ile  Pro Ala Met 
    1100                 1105                 1110             


Ala Xaa  Asn Pro Gln Asn Ala  Ala Ser Arg Arg Xaa  Pro Asn Asn 
    1115                 1120                 1125             


Pro Gly  Asn Pro Ser Asn Pro  Gly Pro Pro Lys Xaa  Pro Glu Asn 
    1130                 1135                 1140             


Ser Leu  Ile Val Xaa Asn Pro  Ser Gly Xaa Gln Xaa  Asn Ser Ala 
    1145                 1150                 1155             


Lys Xaa  Ala Arg Lys Pro Asp  His Xaa Xaa Val Asp  Ile Pro Pro 
    1160                 1165                 1170             


Ala Cys  Pro Pro Pro Leu Asn  His Xaa Val Val Gln  Val Asn Lys 
    1175                 1180                 1185             


Asn Ala  Asn Pro Asp Pro Leu  Pro Lys Lys Glu Glu  Glu Lys Lys 
    1190                 1195                 1200             


Glu Glu  Glu Glu Asp Asp Arg  Gly Glu Asp Gly Pro  Lys Pro Met 
    1205                 1210                 1215             


Pro Pro  Tyr Ser Ser Met Phe  Ile Leu Ser Xaa Xaa  Asn Pro Leu 
    1220                 1225                 1230             


Arg Arg  Leu Cys His Tyr Ile  Leu Asn Leu Arg Tyr  Phe Glu Met 
    1235                 1240                 1245             


Cys Ile  Leu Met Val Ile Ala  Met Ser Ser Ile Ala  Leu Ala Ala 
    1250                 1255                 1260             


Glu Asp  Pro Val Gln Pro Asn  Ala Pro Arg Asn Asn  Val Leu Arg 
    1265                 1270                 1275             


Tyr Phe  Asp Tyr Val Phe Xaa  Gly Val Phe Xaa Phe  Glu Met Val 
    1280                 1285                 1290             


Ile Lys  Met Ile Asp Leu Gly  Leu Val Leu His Gln  Gly Ala Tyr 
    1295                 1300                 1305             


Phe Arg  Asp Leu Trp Asn Ile  Leu Asp Phe Ile Val  Val Ser Gly 
    1310                 1315                 1320             


Ala Leu  Val Ala Phe Ala Phe  Xaa Gly Asn Ser Lys  Gly Lys Asp 
    1325                 1330                 1335             


Ile Asn  Xaa Ile Lys Ser Leu  Arg Val Leu Arg Val  Leu Arg Pro 
    1340                 1345                 1350             


Leu Lys  Xaa Ile Lys Arg Leu  Pro Lys Leu Lys Ala  Val Phe Asp 
    1355                 1360                 1365             


Cys Val  Val Asn Ser Leu Lys  Asn Val Phe Asn Ile  Leu Ile Val 
    1370                 1375                 1380             


Tyr Met  Leu Phe Met Phe Ile  Phe Ala Val Val Ala  Val Gln Leu 
    1385                 1390                 1395             


Phe Lys  Gly Lys Phe Phe His  Cys Xaa Asp Glu Ser  Lys Glu Phe 
    1400                 1405                 1410             


Glu Lys  Asp Cys Arg Gly Lys  Tyr Leu Leu Tyr Glu  Lys Asn Glu 
    1415                 1420                 1425             


Val Lys  Ala Arg Asp Arg Glu  Trp Lys Lys Tyr Glu  Phe His Tyr 
    1430                 1435                 1440             


Asp Asn  Val Leu Trp Ala Leu  Leu Xaa Leu Phe Xaa  Val Ser Xaa 
    1445                 1450                 1455             


Gly Glu  Gly Trp Pro Gln Val  Leu Lys His Ser Val  Asp Ala Xaa 
    1460                 1465                 1470             


Phe Glu  Asn Gln Gly Pro Ser  Pro Gly Tyr Arg Met  Glu Met Ser 
    1475                 1480                 1485             


Ile Phe  Tyr Val Val Tyr Phe  Val Val Phe Pro Phe  Phe Phe Val 
    1490                 1495                 1500             


Asn Ile  Phe Val Ala Leu Ile  Ile Ile Xaa Phe Gln  Glu Gln Gly 
    1505                 1510                 1515             


Asp Lys  Met Met Glu Glu Tyr  Ser Leu Glu Lys Asn  Glu Arg Ala 
    1520                 1525                 1530             


Cys Ile  Asp Phe Ala Ile Ser  Ala Lys Pro Leu Xaa  Arg His Met 
    1535                 1540                 1545             


Pro Gln  Asn Lys Gln Ser Phe  Gln Tyr Arg Met Trp  Gln Phe Val 
    1550                 1555                 1560             


Val Ser  Pro Pro Phe Glu Tyr  Xaa Ile Met Ala Met  Ile Ala Leu 
    1565                 1570                 1575             


Asn Xaa  Ile Val Leu Met Met  Lys Phe Tyr Gly Ala  Ser Val Ala 
    1580                 1585                 1590             


Tyr Glu  Asn Ala Leu Arg Val  Phe Asn Ile Val Phe  Xaa Ser Leu 
    1595                 1600                 1605             


Phe Ser  Leu Glu Cys Val Leu  Lys Val Met Ala Phe  Gly Ile Leu 
    1610                 1615                 1620             


Asn Tyr  Phe Arg Asp Ala Trp  Asn Ile Phe Asp Phe  Val Xaa Val 
    1625                 1630                 1635             


Leu Gly  Ser Ile Xaa Asp Ile  Leu Val Xaa Glu Phe  Gly Asn Asn 
    1640                 1645                 1650             


Phe Ile  Asn Leu Ser Phe Leu  Arg Leu Phe Arg Ala  Ala Arg Leu 
    1655                 1660                 1665             


Ile Lys  Leu Leu Arg Gln Gly  Tyr Xaa Ile Arg Ile  Leu Leu Trp 
    1670                 1675                 1680             


Xaa Phe  Val Gln Ser Phe Lys  Ala Leu Pro Tyr Val  Cys Leu Leu 
    1685                 1690                 1695             


Ile Ala  Met Leu Phe Phe Ile  Tyr Ala Ile Ile Gly  Met Gln Val 
    1700                 1705                 1710             


Phe Gly  Asn Ile Gly Ile Asp  Val Glu Asp Glu Asp  Ser Asp Glu 
    1715                 1720                 1725             


Asp Glu  Phe Gln Ile Xaa Glu  His Asn Asn Phe Arg  Xaa Phe Phe 
    1730                 1735                 1740             


Gln Ala  Leu Met Leu Leu Phe  Arg Ser Ala Xaa Gly  Glu Ala Trp 
    1745                 1750                 1755             


His Asn  Ile Met Leu Ser Cys  Leu Ser Gly Lys Pro  Cys Asp Lys 
    1760                 1765                 1770             


Asn Ser  Gly Ile Leu Xaa Arg  Glu Cys Gly Asn Glu  Phe Ala Tyr 
    1775                 1780                 1785             


Phe Tyr  Phe Val Ser Phe Ile  Phe Leu Cys Ser Phe  Leu Met Leu 
    1790                 1795                 1800             


Asn Leu  Phe Val Ala Val Ile  Met Asp Asn Phe Glu  Tyr Leu Xaa 
    1805                 1810                 1815             


Arg Asp  Ser Ser Ile Leu Gly  Pro His His Leu Asp  Glu Tyr Val 
    1820                 1825                 1830             


Arg Val  Trp Ala Glu Tyr Asp  Pro Ala Ala Cys Gly  Arg Ile His 
    1835                 1840                 1845             


Tyr Lys  Asp Met Tyr Ser Leu  Leu Arg Val Ile Ser  Pro Pro Leu 
    1850                 1855                 1860             


Gly Leu  Gly Lys Lys Cys Pro  His Arg Val Ala Cys  Lys Arg Leu 
    1865                 1870                 1875             


Leu Arg  Met Asp Leu Pro Val  Ala Asp Asp Asn Xaa  Val His Phe 
    1880                 1885                 1890             


Asn Ser  Xaa Leu Met Ala Leu  Ile Arg Xaa Ala Leu  Asp Ile Lys 
    1895                 1900                 1905             


Ile Ala  Lys Gly Gly Ala Asp  Lys Gln Gln Met Asp  Ala Glu Leu 
    1910                 1915                 1920             


Arg Lys  Glu Met Met Ala Ile  Trp Pro Asn Leu Ser  Gln Lys Xaa 
    1925                 1930                 1935             


Leu Asp  Leu Leu Val Xaa Pro  His Lys Ser Xaa Asp  Leu Xaa Val 
    1940                 1945                 1950             


Gly Lys  Ile Tyr Ala Ala Met  Met Ile Met Glu Tyr  Tyr Arg Gln 
    1955                 1960                 1965             


Ser Lys  Ala Lys Lys Leu Gln  Ala Met Arg Glu Glu  Gln Asp Arg 
    1970                 1975                 1980             


Xaa Pro  Leu Met Phe Gln Arg  Met Glu Pro Pro Ser  Pro Xaa Gln 
    1985                 1990                 1995             


Glu Gly  Gly Pro Gly Gln Asn  Ala Leu Pro Ser Xaa  Gln Leu Asp 
    2000                 2005                 2010             


Pro Gly  Gly Ala Leu Met Ala  His Glu Ser Gly Leu  Lys Glu Ser 
    2015                 2020                 2025             


Pro Ser  Trp Val Xaa Gln Arg  Ala Gln Glu Met Phe  Gln Lys Xaa 
    2030                 2035                 2040             


Gly Xaa  Trp Ser Pro Glu Gln  Gly Pro Pro Xaa Asp  Met Pro Asn 
    2045                 2050                 2055             


Ser Gln  Pro Asn Ser Gln Ser  Val Glu Met Arg Glu  Met Gly Arg 
    2060                 2065                 2070             


Asp Gly  Tyr Ser Asp Ser Glu  His Tyr Leu Pro Met  Glu Gly Gln 
    2075                 2080                 2085             


Gly Arg  Ala Ala Ser Met Pro  Arg Leu Pro Ala Glu  Asn Gln Arg 
    2090                 2095                 2100             


Arg Arg  Gly Arg Pro Arg Gly  Asn Asn Leu Ser Xaa  Ile Ser Asp 
    2105                 2110                 2115             


Xaa Ser  Pro Met Lys Arg Ser  Ala Ser Val Leu Gly  Pro Lys Ala 
    2120                 2125                 2130             


Arg Arg  Leu Asp Asp Tyr Ser  Leu Glu Arg Val Pro  Pro Glu Glu 
    2135                 2140                 2145             


Asn Gln  Arg His His Gln Arg  Arg Arg Asp Arg Ser  His Arg Ala 
    2150                 2155                 2160             


Ser Glu  Arg Ser Leu Gly Arg  Tyr Xaa Asp Val Asp  Xaa Gly Leu 
    2165                 2170                 2175             


Gly Xaa  Asp Leu Ser Met Xaa  Xaa Gln Ser Gly Asp  Leu Pro Ser 
    2180                 2185                 2190             


Lys Glu  Arg Asp Gln Glu Arg  Gly Arg Pro Lys Asp  Arg Lys His 
    2195                 2200                 2205             


Arg Gln  His His His His His  His His His His His  Pro Pro Pro 
    2210                 2215                 2220             


Pro Asp  Lys Asp Arg Tyr Ala  Gln Glu Arg Pro Asp  His Gly Arg 
    2225                 2230                 2235             


Ala Arg  Ala Arg Asp Gln Arg  Trp Ser Arg Ser Pro  Ser Glu Gly 
    2240                 2245                 2250             


Arg Glu  His Met Ala His Arg  Gln 
    2255                 2260     


<210> 4629
<211> 2261
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1356)..(1356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1452)..(1452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1571)..(1571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1580)..(1580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1637)..(1637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1643)..(1643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1648)..(1648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1677)..(1677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1684)..(1684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1734)..(1734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1741)..(1741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1779)..(1779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1818)..(1818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1890)..(1890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1896)..(1896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1903)..(1903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1938)..(1938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1944)..(1944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1949)..(1949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1952)..(1952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1984)..(1984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1997)..(1997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2010)..(2010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2033)..(2033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2043)..(2043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2045)..(2045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2054)..(2054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2115)..(2115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2119)..(2119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2172)..(2172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2176)..(2176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2180)..(2180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2185)..(2186)
<223> Selenocysteine

<400> 4629
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Xaa Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Xaa Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Xaa Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Xaa Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Xaa Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Xaa Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Xaa Gly Ile Leu Ala Xaa Val Gly Xaa Glu Phe Asp Leu Arg 
            180                 185                 190         


Xaa Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Xaa Xaa Cys 
                245                 250                 255     


Phe Glu Glu Gly Xaa Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Xaa Glu Glu Pro Ala Arg Xaa Cys Pro Asn Gly Xaa Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Xaa Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp 
305                 310                 315                 320 


Xaa Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Xaa Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Xaa Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Gly Ala Leu Arg Arg Xaa Xaa Ile Lys Lys Ser Lys Xaa Asp 
            420                 425                 430         


Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser 
        435                 440                 445             


Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu 
    450                 455                 460                 


Asn Ser Xaa Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile 
465                 470                 475                 480 


Arg Arg Met Val Lys Xaa Gln Ala Phe Tyr Trp Xaa Val Leu Ser Leu 
                485                 490                 495     


Val Ala Leu Asn Xaa Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro 
            500                 505                 510         


Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly 
        515                 520                 525             


Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Xaa Arg 
    530                 535                 540                 


Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile 
545                 550                 555                 560 


Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Xaa Ser 
                565                 570                 575     


Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys 
            580                 585                 590         


Val Xaa Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu 
        595                 600                 605             


Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe 
    610                 615                 620                 


Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe 
625                 630                 635                 640 


Asn Phe Asp Glu Gly Xaa Pro Pro Xaa Asn Phe Asp Xaa Phe Pro Ala 
                645                 650                 655     


Ala Ile Met Xaa Val Phe Gln Ile Leu Xaa Gly Glu Asp Trp Asn Glu 
            660                 665                 670         


Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met 
        675                 680                 685             


Val Phe Ser Ile Tyr Phe Ile Val Leu Xaa Leu Phe Gly Asn Tyr Xaa 
    690                 695                 700                 


Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala 
705                 710                 715                 720 


Gln Glu Leu Xaa Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln 
                725                 730                 735     


Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu 
            740                 745                 750         


Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln 
        755                 760                 765             


Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Xaa Ser Glu Met Arg Lys 
    770                 775                 780                 


Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro 
785                 790                 795                 800 


Asp Glu Arg Trp Lys Ala Ala Tyr Xaa Arg His Leu Arg Pro Asp Met 
                805                 810                 815     


Lys Xaa His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg 
            820                 825                 830         


Asn Asn Asn Xaa Asn Lys Ser Arg Ala Ala Glu Pro Xaa Val Asp Gln 
        835                 840                 845             


Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg 
    850                 855                 860                 


Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala 
865                 870                 875                 880 


Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly 
                885                 890                 895     


Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu 
            900                 905                 910         


Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp 
        915                 920                 925             


Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg 
    930                 935                 940                 


Ser Gly Ser Pro Arg Xaa Gly Ala Asp Gly Glu His Arg Arg His Arg 
945                 950                 955                 960 


Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg 
                965                 970                 975     


Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly 
            980                 985                 990         


Glu Gly Glu Gly Pro Asp Gly Gly  Glu Arg Arg Arg Arg  His Arg His 
        995                 1000                 1005             


Gly Ala  Pro Ala Xaa Tyr Glu  Gly Asp Ala Arg Arg  Glu Asp Lys 
    1010                 1015                 1020             


Glu Arg  Arg His Arg Arg Arg  Lys Glu Asn Gln Gly  Ser Gly Val 
    1025                 1030                 1035             


Pro Val  Ser Gly Pro Asn Leu  Ser Xaa Xaa Arg Pro  Ile Gln Gln 
    1040                 1045                 1050             


Asp Leu  Gly Arg Gln Asp Pro  Pro Leu Ala Glu Asp  Ile Asp Asn 
    1055                 1060                 1065             


Met Lys  Asn Asn Lys Leu Ala  Xaa Ala Glu Ser Ala  Ala Pro His 
    1070                 1075                 1080             


Gly Ser  Leu Gly His Ala Gly  Leu Pro Gln Ser Pro  Ala Lys Met 
    1085                 1090                 1095             


Gly Asn  Ser Xaa Asp Pro Gly  Pro Met Leu Ala Ile  Pro Ala Met 
    1100                 1105                 1110             


Ala Xaa  Asn Pro Gln Asn Ala  Ala Ser Arg Arg Xaa  Pro Asn Asn 
    1115                 1120                 1125             


Pro Gly  Asn Pro Ser Asn Pro  Gly Pro Pro Lys Xaa  Pro Glu Asn 
    1130                 1135                 1140             


Ser Leu  Ile Val Xaa Asn Pro  Ser Gly Xaa Gln Xaa  Asn Ser Ala 
    1145                 1150                 1155             


Lys Xaa  Ala Arg Lys Pro Asp  His Xaa Xaa Val Asp  Ile Pro Pro 
    1160                 1165                 1170             


Ala Cys  Pro Pro Pro Leu Asn  His Xaa Val Val Gln  Val Asn Lys 
    1175                 1180                 1185             


Asn Ala  Asn Pro Asp Pro Leu  Pro Lys Lys Glu Glu  Glu Lys Lys 
    1190                 1195                 1200             


Glu Glu  Glu Glu Asp Asp Arg  Gly Glu Asp Gly Pro  Lys Pro Met 
    1205                 1210                 1215             


Pro Pro  Tyr Ser Ser Met Phe  Ile Leu Ser Xaa Xaa  Asn Pro Leu 
    1220                 1225                 1230             


Arg Arg  Leu Cys His Tyr Ile  Leu Asn Leu Arg Tyr  Phe Glu Met 
    1235                 1240                 1245             


Cys Ile  Leu Met Val Ile Ala  Met Ser Ser Ile Ala  Leu Ala Ala 
    1250                 1255                 1260             


Glu Asp  Pro Val Gln Pro Asn  Ala Pro Arg Asn Asn  Val Leu Arg 
    1265                 1270                 1275             


Tyr Phe  Asp Tyr Val Phe Xaa  Gly Val Phe Xaa Phe  Glu Met Val 
    1280                 1285                 1290             


Ile Lys  Met Ile Asp Leu Gly  Leu Val Leu His Gln  Gly Ala Tyr 
    1295                 1300                 1305             


Phe Arg  Asp Leu Trp Asn Ile  Leu Asp Phe Ile Val  Val Ser Gly 
    1310                 1315                 1320             


Ala Leu  Val Ala Phe Ala Phe  Xaa Gly Asn Ser Lys  Gly Lys Asp 
    1325                 1330                 1335             


Ile Asn  Xaa Ile Lys Ser Leu  Arg Val Leu Arg Val  Leu Arg Pro 
    1340                 1345                 1350             


Leu Lys  Xaa Ile Lys Arg Leu  Pro Lys Leu Lys Ala  Val Phe Asp 
    1355                 1360                 1365             


Cys Val  Val Asn Ser Leu Lys  Asn Val Phe Asn Ile  Leu Ile Val 
    1370                 1375                 1380             


Tyr Met  Leu Phe Met Phe Ile  Phe Ala Val Val Ala  Val Gln Leu 
    1385                 1390                 1395             


Phe Lys  Gly Lys Phe Phe His  Cys Xaa Asp Glu Ser  Lys Glu Phe 
    1400                 1405                 1410             


Glu Lys  Asp Cys Arg Gly Lys  Tyr Leu Leu Tyr Glu  Lys Asn Glu 
    1415                 1420                 1425             


Val Lys  Ala Arg Asp Arg Glu  Trp Lys Lys Tyr Glu  Phe His Tyr 
    1430                 1435                 1440             


Asp Asn  Val Leu Trp Ala Leu  Leu Xaa Leu Phe Xaa  Val Ser Xaa 
    1445                 1450                 1455             


Gly Glu  Gly Trp Pro Gln Val  Leu Lys His Ser Val  Asp Ala Xaa 
    1460                 1465                 1470             


Phe Glu  Asn Gln Gly Pro Ser  Pro Gly Tyr Arg Met  Glu Met Ser 
    1475                 1480                 1485             


Ile Phe  Tyr Val Val Tyr Phe  Val Val Phe Pro Phe  Phe Phe Val 
    1490                 1495                 1500             


Asn Ile  Phe Val Ala Leu Ile  Ile Ile Xaa Phe Gln  Glu Gln Gly 
    1505                 1510                 1515             


Asp Lys  Met Met Glu Glu Tyr  Ser Leu Glu Lys Asn  Glu Arg Ala 
    1520                 1525                 1530             


Cys Ile  Asp Phe Ala Ile Ser  Ala Lys Pro Leu Xaa  Arg His Met 
    1535                 1540                 1545             


Pro Gln  Asn Lys Gln Ser Phe  Gln Tyr Arg Met Trp  Gln Phe Val 
    1550                 1555                 1560             


Val Ser  Pro Pro Phe Glu Tyr  Xaa Ile Met Ala Met  Ile Ala Leu 
    1565                 1570                 1575             


Asn Xaa  Ile Val Leu Met Met  Lys Phe Tyr Gly Ala  Ser Val Ala 
    1580                 1585                 1590             


Tyr Glu  Asn Ala Leu Arg Val  Phe Asn Ile Val Phe  Xaa Ser Leu 
    1595                 1600                 1605             


Phe Ser  Leu Glu Cys Val Leu  Lys Val Met Ala Phe  Gly Ile Leu 
    1610                 1615                 1620             


Asn Tyr  Phe Arg Asp Ala Trp  Asn Ile Phe Asp Phe  Val Xaa Val 
    1625                 1630                 1635             


Leu Gly  Ser Ile Xaa Asp Ile  Leu Val Xaa Glu Phe  Gly Asn Asn 
    1640                 1645                 1650             


Phe Ile  Asn Leu Ser Phe Leu  Arg Leu Phe Arg Ala  Ala Arg Leu 
    1655                 1660                 1665             


Ile Lys  Leu Leu Arg Gln Gly  Tyr Xaa Ile Arg Ile  Leu Leu Trp 
    1670                 1675                 1680             


Xaa Phe  Val Gln Ser Phe Lys  Ala Leu Pro Tyr Val  Cys Leu Leu 
    1685                 1690                 1695             


Ile Ala  Met Leu Phe Phe Ile  Tyr Ala Ile Ile Gly  Met Gln Val 
    1700                 1705                 1710             


Phe Gly  Asn Ile Gly Ile Asp  Val Glu Asp Glu Asp  Ser Asp Glu 
    1715                 1720                 1725             


Asp Glu  Phe Gln Ile Xaa Glu  His Asn Asn Phe Arg  Xaa Phe Phe 
    1730                 1735                 1740             


Gln Ala  Leu Met Leu Leu Phe  Arg Ser Ala Xaa Gly  Glu Ala Trp 
    1745                 1750                 1755             


His Asn  Ile Met Leu Ser Cys  Leu Ser Gly Lys Pro  Cys Asp Lys 
    1760                 1765                 1770             


Asn Ser  Gly Ile Leu Xaa Arg  Glu Cys Gly Asn Glu  Phe Ala Tyr 
    1775                 1780                 1785             


Phe Tyr  Phe Val Ser Phe Ile  Phe Leu Cys Ser Phe  Leu Met Leu 
    1790                 1795                 1800             


Asn Leu  Phe Val Ala Val Ile  Met Asp Asn Phe Glu  Tyr Leu Xaa 
    1805                 1810                 1815             


Arg Asp  Ser Ser Ile Leu Gly  Pro His His Leu Asp  Glu Tyr Val 
    1820                 1825                 1830             


Arg Val  Trp Ala Glu Tyr Asp  Pro Ala Ala Trp Gly  Arg Met Pro 
    1835                 1840                 1845             


Tyr Leu  Asp Met Tyr Gln Met  Leu Arg His Met Ser  Pro Pro Leu 
    1850                 1855                 1860             


Gly Leu  Gly Lys Lys Cys Pro  Ala Arg Val Ala Tyr  Lys Arg Leu 
    1865                 1870                 1875             


Leu Arg  Met Asp Leu Pro Val  Ala Asp Asp Asn Xaa  Val His Phe 
    1880                 1885                 1890             


Asn Ser  Xaa Leu Met Ala Leu  Ile Arg Xaa Ala Leu  Asp Ile Lys 
    1895                 1900                 1905             


Ile Ala  Lys Gly Gly Ala Asp  Lys Gln Gln Met Asp  Ala Glu Leu 
    1910                 1915                 1920             


Arg Lys  Glu Met Met Ala Ile  Trp Pro Asn Leu Ser  Gln Lys Xaa 
    1925                 1930                 1935             


Leu Asp  Leu Leu Val Xaa Pro  His Lys Ser Xaa Asp  Leu Xaa Val 
    1940                 1945                 1950             


Gly Lys  Ile Tyr Ala Ala Met  Met Ile Met Glu Tyr  Tyr Arg Gln 
    1955                 1960                 1965             


Ser Lys  Ala Lys Lys Leu Gln  Ala Met Arg Glu Glu  Gln Asp Arg 
    1970                 1975                 1980             


Xaa Pro  Leu Met Phe Gln Arg  Met Glu Pro Pro Ser  Pro Xaa Gln 
    1985                 1990                 1995             


Glu Gly  Gly Pro Gly Gln Asn  Ala Leu Pro Ser Xaa  Gln Leu Asp 
    2000                 2005                 2010             


Pro Gly  Gly Ala Leu Met Ala  His Glu Ser Gly Leu  Lys Glu Ser 
    2015                 2020                 2025             


Pro Ser  Trp Val Xaa Gln Arg  Ala Gln Glu Met Phe  Gln Lys Xaa 
    2030                 2035                 2040             


Gly Xaa  Trp Ser Pro Glu Gln  Gly Pro Pro Xaa Asp  Met Pro Asn 
    2045                 2050                 2055             


Ser Gln  Pro Asn Ser Gln Ser  Val Glu Met Arg Glu  Met Gly Arg 
    2060                 2065                 2070             


Asp Gly  Tyr Ser Asp Ser Glu  His Tyr Leu Pro Met  Glu Gly Gln 
    2075                 2080                 2085             


Gly Arg  Ala Ala Ser Met Pro  Arg Leu Pro Ala Glu  Asn Gln Arg 
    2090                 2095                 2100             


Arg Arg  Gly Arg Pro Arg Gly  Asn Asn Leu Ser Xaa  Ile Ser Asp 
    2105                 2110                 2115             


Xaa Ser  Pro Met Lys Arg Ser  Ala Ser Val Leu Gly  Pro Lys Ala 
    2120                 2125                 2130             


Arg Arg  Leu Asp Asp Tyr Ser  Leu Glu Arg Val Pro  Pro Glu Glu 
    2135                 2140                 2145             


Asn Gln  Arg His His Gln Arg  Arg Arg Asp Arg Ser  His Arg Ala 
    2150                 2155                 2160             


Ser Glu  Arg Ser Leu Gly Arg  Tyr Xaa Asp Val Asp  Xaa Gly Leu 
    2165                 2170                 2175             


Gly Xaa  Asp Leu Ser Met Xaa  Xaa Gln Ser Gly Asp  Leu Pro Ser 
    2180                 2185                 2190             


Lys Glu  Arg Asp Gln Glu Arg  Gly Arg Pro Lys Asp  Arg Lys His 
    2195                 2200                 2205             


Arg Gln  His His His His His  His His His His His  Pro Pro Pro 
    2210                 2215                 2220             


Pro Asp  Lys Asp Arg Tyr Ala  Gln Glu Arg Pro Asp  His Gly Arg 
    2225                 2230                 2235             


Ala Arg  Ala Arg Asp Gln Arg  Trp Ser Arg Ser Pro  Ser Glu Gly 
    2240                 2245                 2250             


Arg Glu  His Met Ala His Arg  Gln 
    2255                 2260     


<210> 4630
<211> 2262
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1103)..(1103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1161)..(1161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1342)..(1342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1357)..(1357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1453)..(1453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1456)..(1456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1459)..(1459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1474)..(1474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1514)..(1514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1546)..(1546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1572)..(1572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1581)..(1581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1638)..(1638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1644)..(1644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1649)..(1649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1678)..(1678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1685)..(1685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1735)..(1735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1742)..(1742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1755)..(1755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1780)..(1780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1819)..(1819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1891)..(1891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1897)..(1897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1904)..(1904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1939)..(1939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1945)..(1945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1950)..(1950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1953)..(1953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1985)..(1985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1998)..(1998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2011)..(2011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2034)..(2034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2044)..(2044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2046)..(2046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2055)..(2055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2116)..(2116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2120)..(2120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2173)..(2173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2177)..(2177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2181)..(2181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2186)..(2187)
<223> Selenocysteine

<400> 4630
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Xaa Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Xaa Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Xaa Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Xaa Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Xaa Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Xaa Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Xaa Gly Ile Leu Ala Xaa Val Gly Xaa Glu Phe Asp Leu Arg 
            180                 185                 190         


Xaa Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Xaa Xaa Cys 
                245                 250                 255     


Phe Glu Glu Gly Xaa Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Xaa Glu Glu Pro Ala Arg Xaa Cys Pro Asn Gly Xaa Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Xaa Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp 
305                 310                 315                 320 


Xaa Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Xaa Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Xaa Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Val Gly Ala Leu Arg Arg Xaa Xaa Ile Lys Lys Ser Lys Xaa 
            420                 425                 430         


Asp Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala 
        435                 440                 445             


Ser Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu 
    450                 455                 460                 


Glu Asn Ser Xaa Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr 
465                 470                 475                 480 


Ile Arg Arg Met Val Lys Xaa Gln Ala Phe Tyr Trp Xaa Val Leu Ser 
                485                 490                 495     


Leu Val Ala Leu Asn Xaa Leu Cys Val Ala Ile Val His Tyr Asn Gln 
            500                 505                 510         


Pro Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu 
        515                 520                 525             


Gly Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Xaa 
    530                 535                 540                 


Arg Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile 
545                 550                 555                 560 


Ile Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Xaa 
                565                 570                 575     


Ser Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe 
            580                 585                 590         


Lys Val Xaa Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu 
        595                 600                 605             


Leu Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu 
    610                 615                 620                 


Phe Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln 
625                 630                 635                 640 


Phe Asn Phe Asp Glu Gly Xaa Pro Pro Xaa Asn Phe Asp Xaa Phe Pro 
                645                 650                 655     


Ala Ala Ile Met Xaa Val Phe Gln Ile Leu Xaa Gly Glu Asp Trp Asn 
            660                 665                 670         


Glu Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly 
        675                 680                 685             


Met Val Phe Ser Ile Tyr Phe Ile Val Leu Xaa Leu Phe Gly Asn Tyr 
    690                 695                 700                 


Xaa Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn 
705                 710                 715                 720 


Ala Gln Glu Leu Xaa Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn 
                725                 730                 735     


Gln Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro 
            740                 745                 750         


Leu Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn 
        755                 760                 765             


Gln Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Xaa Ser Glu Met Arg 
    770                 775                 780                 


Lys Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp 
785                 790                 795                 800 


Pro Asp Glu Arg Trp Lys Ala Ala Tyr Xaa Arg His Leu Arg Pro Asp 
                805                 810                 815     


Met Lys Xaa His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn 
            820                 825                 830         


Arg Asn Asn Asn Xaa Asn Lys Ser Arg Ala Ala Glu Pro Xaa Val Asp 
        835                 840                 845             


Gln Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala 
    850                 855                 860                 


Arg Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp 
865                 870                 875                 880 


Ala Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu 
                885                 890                 895     


Gly Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu 
            900                 905                 910         


Glu Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly 
        915                 920                 925             


Asp Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser 
    930                 935                 940                 


Arg Ser Gly Ser Pro Arg Xaa Gly Ala Asp Gly Glu His Arg Arg His 
945                 950                 955                 960 


Arg Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu 
                965                 970                 975     


Arg Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu 
            980                 985                 990         


Gly Glu Gly Glu Gly Pro Asp Gly  Gly Glu Arg Arg Arg  Arg His Arg 
        995                 1000                 1005             


His Gly  Ala Pro Ala Xaa Tyr  Glu Gly Asp Ala Arg  Arg Glu Asp 
    1010                 1015                 1020             


Lys Glu  Arg Arg His Arg Arg  Arg Lys Glu Asn Gln  Gly Ser Gly 
    1025                 1030                 1035             


Val Pro  Val Ser Gly Pro Asn  Leu Ser Xaa Xaa Arg  Pro Ile Gln 
    1040                 1045                 1050             


Gln Asp  Leu Gly Arg Gln Asp  Pro Pro Leu Ala Glu  Asp Ile Asp 
    1055                 1060                 1065             


Asn Met  Lys Asn Asn Lys Leu  Ala Xaa Ala Glu Ser  Ala Ala Pro 
    1070                 1075                 1080             


His Gly  Ser Leu Gly His Ala  Gly Leu Pro Gln Ser  Pro Ala Lys 
    1085                 1090                 1095             


Met Gly  Asn Ser Xaa Asp Pro  Gly Pro Met Leu Ala  Ile Pro Ala 
    1100                 1105                 1110             


Met Ala  Xaa Asn Pro Gln Asn  Ala Ala Ser Arg Arg  Xaa Pro Asn 
    1115                 1120                 1125             


Asn Pro  Gly Asn Pro Ser Asn  Pro Gly Pro Pro Lys  Xaa Pro Glu 
    1130                 1135                 1140             


Asn Ser  Leu Ile Val Xaa Asn  Pro Ser Gly Xaa Gln  Xaa Asn Ser 
    1145                 1150                 1155             


Ala Lys  Xaa Ala Arg Lys Pro  Asp His Xaa Xaa Val  Asp Ile Pro 
    1160                 1165                 1170             


Pro Ala  Cys Pro Pro Pro Leu  Asn His Xaa Val Val  Gln Val Asn 
    1175                 1180                 1185             


Lys Asn  Ala Asn Pro Asp Pro  Leu Pro Lys Lys Glu  Glu Glu Lys 
    1190                 1195                 1200             


Lys Glu  Glu Glu Glu Asp Asp  Arg Gly Glu Asp Gly  Pro Lys Pro 
    1205                 1210                 1215             


Met Pro  Pro Tyr Ser Ser Met  Phe Ile Leu Ser Xaa  Xaa Asn Pro 
    1220                 1225                 1230             


Leu Arg  Arg Leu Cys His Tyr  Ile Leu Asn Leu Arg  Tyr Phe Glu 
    1235                 1240                 1245             


Met Cys  Ile Leu Met Val Ile  Ala Met Ser Ser Ile  Ala Leu Ala 
    1250                 1255                 1260             


Ala Glu  Asp Pro Val Gln Pro  Asn Ala Pro Arg Asn  Asn Val Leu 
    1265                 1270                 1275             


Arg Tyr  Phe Asp Tyr Val Phe  Xaa Gly Val Phe Xaa  Phe Glu Met 
    1280                 1285                 1290             


Val Ile  Lys Met Ile Asp Leu  Gly Leu Val Leu His  Gln Gly Ala 
    1295                 1300                 1305             


Tyr Phe  Arg Asp Leu Trp Asn  Ile Leu Asp Phe Ile  Val Val Ser 
    1310                 1315                 1320             


Gly Ala  Leu Val Ala Phe Ala  Phe Xaa Gly Asn Ser  Lys Gly Lys 
    1325                 1330                 1335             


Asp Ile  Asn Xaa Ile Lys Ser  Leu Arg Val Leu Arg  Val Leu Arg 
    1340                 1345                 1350             


Pro Leu  Lys Xaa Ile Lys Arg  Leu Pro Lys Leu Lys  Ala Val Phe 
    1355                 1360                 1365             


Asp Cys  Val Val Asn Ser Leu  Lys Asn Val Phe Asn  Ile Leu Ile 
    1370                 1375                 1380             


Val Tyr  Met Leu Phe Met Phe  Ile Phe Ala Val Val  Ala Val Gln 
    1385                 1390                 1395             


Leu Phe  Lys Gly Lys Phe Phe  His Cys Xaa Asp Glu  Ser Lys Glu 
    1400                 1405                 1410             


Phe Glu  Lys Asp Cys Arg Gly  Lys Tyr Leu Leu Tyr  Glu Lys Asn 
    1415                 1420                 1425             


Glu Val  Lys Ala Arg Asp Arg  Glu Trp Lys Lys Tyr  Glu Phe His 
    1430                 1435                 1440             


Tyr Asp  Asn Val Leu Trp Ala  Leu Leu Xaa Leu Phe  Xaa Val Ser 
    1445                 1450                 1455             


Xaa Gly  Glu Gly Trp Pro Gln  Val Leu Lys His Ser  Val Asp Ala 
    1460                 1465                 1470             


Xaa Phe  Glu Asn Gln Gly Pro  Ser Pro Gly Tyr Arg  Met Glu Met 
    1475                 1480                 1485             


Ser Ile  Phe Tyr Val Val Tyr  Phe Val Val Phe Pro  Phe Phe Phe 
    1490                 1495                 1500             


Val Asn  Ile Phe Val Ala Leu  Ile Ile Ile Xaa Phe  Gln Glu Gln 
    1505                 1510                 1515             


Gly Asp  Lys Met Met Glu Glu  Tyr Ser Leu Glu Lys  Asn Glu Arg 
    1520                 1525                 1530             


Ala Cys  Ile Asp Phe Ala Ile  Ser Ala Lys Pro Leu  Xaa Arg His 
    1535                 1540                 1545             


Met Pro  Gln Asn Lys Gln Ser  Phe Gln Tyr Arg Met  Trp Gln Phe 
    1550                 1555                 1560             


Val Val  Ser Pro Pro Phe Glu  Tyr Xaa Ile Met Ala  Met Ile Ala 
    1565                 1570                 1575             


Leu Asn  Xaa Ile Val Leu Met  Met Lys Phe Tyr Gly  Ala Ser Val 
    1580                 1585                 1590             


Ala Tyr  Glu Asn Ala Leu Arg  Val Phe Asn Ile Val  Phe Xaa Ser 
    1595                 1600                 1605             


Leu Phe  Ser Leu Glu Cys Val  Leu Lys Val Met Ala  Phe Gly Ile 
    1610                 1615                 1620             


Leu Asn  Tyr Phe Arg Asp Ala  Trp Asn Ile Phe Asp  Phe Val Xaa 
    1625                 1630                 1635             


Val Leu  Gly Ser Ile Xaa Asp  Ile Leu Val Xaa Glu  Phe Gly Asn 
    1640                 1645                 1650             


Asn Phe  Ile Asn Leu Ser Phe  Leu Arg Leu Phe Arg  Ala Ala Arg 
    1655                 1660                 1665             


Leu Ile  Lys Leu Leu Arg Gln  Gly Tyr Xaa Ile Arg  Ile Leu Leu 
    1670                 1675                 1680             


Trp Xaa  Phe Val Gln Ser Phe  Lys Ala Leu Pro Tyr  Val Cys Leu 
    1685                 1690                 1695             


Leu Ile  Ala Met Leu Phe Phe  Ile Tyr Ala Ile Ile  Gly Met Gln 
    1700                 1705                 1710             


Val Phe  Gly Asn Ile Gly Ile  Asp Val Glu Asp Glu  Asp Ser Asp 
    1715                 1720                 1725             


Glu Asp  Glu Phe Gln Ile Xaa  Glu His Asn Asn Phe  Arg Xaa Phe 
    1730                 1735                 1740             


Phe Gln  Ala Leu Met Leu Leu  Phe Arg Ser Ala Xaa  Gly Glu Ala 
    1745                 1750                 1755             


Trp His  Asn Ile Met Leu Ser  Cys Leu Ser Gly Lys  Pro Cys Asp 
    1760                 1765                 1770             


Lys Asn  Ser Gly Ile Leu Xaa  Arg Glu Cys Gly Asn  Glu Phe Ala 
    1775                 1780                 1785             


Tyr Phe  Tyr Phe Val Ser Phe  Ile Phe Leu Cys Ser  Phe Leu Met 
    1790                 1795                 1800             


Leu Asn  Leu Phe Val Ala Val  Ile Met Asp Asn Phe  Glu Tyr Leu 
    1805                 1810                 1815             


Xaa Arg  Asp Ser Ser Ile Leu  Gly Pro His His Leu  Asp Glu Tyr 
    1820                 1825                 1830             


Val Arg  Val Trp Ala Glu Tyr  Asp Pro Ala Ala Cys  Gly Arg Ile 
    1835                 1840                 1845             


His Tyr  Lys Asp Met Tyr Ser  Leu Leu Arg Val Ile  Ser Pro Pro 
    1850                 1855                 1860             


Leu Gly  Leu Gly Lys Lys Cys  Pro His Arg Val Ala  Cys Lys Arg 
    1865                 1870                 1875             


Leu Leu  Arg Met Asp Leu Pro  Val Ala Asp Asp Asn  Xaa Val His 
    1880                 1885                 1890             


Phe Asn  Ser Xaa Leu Met Ala  Leu Ile Arg Xaa Ala  Leu Asp Ile 
    1895                 1900                 1905             


Lys Ile  Ala Lys Gly Gly Ala  Asp Lys Gln Gln Met  Asp Ala Glu 
    1910                 1915                 1920             


Leu Arg  Lys Glu Met Met Ala  Ile Trp Pro Asn Leu  Ser Gln Lys 
    1925                 1930                 1935             


Xaa Leu  Asp Leu Leu Val Xaa  Pro His Lys Ser Xaa  Asp Leu Xaa 
    1940                 1945                 1950             


Val Gly  Lys Ile Tyr Ala Ala  Met Met Ile Met Glu  Tyr Tyr Arg 
    1955                 1960                 1965             


Gln Ser  Lys Ala Lys Lys Leu  Gln Ala Met Arg Glu  Glu Gln Asp 
    1970                 1975                 1980             


Arg Xaa  Pro Leu Met Phe Gln  Arg Met Glu Pro Pro  Ser Pro Xaa 
    1985                 1990                 1995             


Gln Glu  Gly Gly Pro Gly Gln  Asn Ala Leu Pro Ser  Xaa Gln Leu 
    2000                 2005                 2010             


Asp Pro  Gly Gly Ala Leu Met  Ala His Glu Ser Gly  Leu Lys Glu 
    2015                 2020                 2025             


Ser Pro  Ser Trp Val Xaa Gln  Arg Ala Gln Glu Met  Phe Gln Lys 
    2030                 2035                 2040             


Xaa Gly  Xaa Trp Ser Pro Glu  Gln Gly Pro Pro Xaa  Asp Met Pro 
    2045                 2050                 2055             


Asn Ser  Gln Pro Asn Ser Gln  Ser Val Glu Met Arg  Glu Met Gly 
    2060                 2065                 2070             


Arg Asp  Gly Tyr Ser Asp Ser  Glu His Tyr Leu Pro  Met Glu Gly 
    2075                 2080                 2085             


Gln Gly  Arg Ala Ala Ser Met  Pro Arg Leu Pro Ala  Glu Asn Gln 
    2090                 2095                 2100             


Arg Arg  Arg Gly Arg Pro Arg  Gly Asn Asn Leu Ser  Xaa Ile Ser 
    2105                 2110                 2115             


Asp Xaa  Ser Pro Met Lys Arg  Ser Ala Ser Val Leu  Gly Pro Lys 
    2120                 2125                 2130             


Ala Arg  Arg Leu Asp Asp Tyr  Ser Leu Glu Arg Val  Pro Pro Glu 
    2135                 2140                 2145             


Glu Asn  Gln Arg His His Gln  Arg Arg Arg Asp Arg  Ser His Arg 
    2150                 2155                 2160             


Ala Ser  Glu Arg Ser Leu Gly  Arg Tyr Xaa Asp Val  Asp Xaa Gly 
    2165                 2170                 2175             


Leu Gly  Xaa Asp Leu Ser Met  Xaa Xaa Gln Ser Gly  Asp Leu Pro 
    2180                 2185                 2190             


Ser Lys  Glu Arg Asp Gln Glu  Arg Gly Arg Pro Lys  Asp Arg Lys 
    2195                 2200                 2205             


His Arg  Gln His His His His  His His His His His  His Pro Pro 
    2210                 2215                 2220             


Pro Pro  Asp Lys Asp Arg Tyr  Ala Gln Glu Arg Pro  Asp His Gly 
    2225                 2230                 2235             


Arg Ala  Arg Ala Arg Asp Gln  Arg Trp Ser Arg Ser  Pro Ser Glu 
    2240                 2245                 2250             


Gly Arg  Glu His Met Ala His  Arg Gln 
    2255                 2260         


<210> 4631
<211> 2263
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1356)..(1356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1452)..(1452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1571)..(1571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1580)..(1580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1637)..(1637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1643)..(1643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1648)..(1648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1679)..(1679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1686)..(1686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1736)..(1736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1743)..(1743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1756)..(1756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1781)..(1781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1820)..(1820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1892)..(1892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1898)..(1898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1905)..(1905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1940)..(1940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1946)..(1946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1951)..(1951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1954)..(1954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1986)..(1986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1999)..(1999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2012)..(2012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2035)..(2035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2045)..(2045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2047)..(2047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2056)..(2056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2117)..(2117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2121)..(2121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2174)..(2174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2178)..(2178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2182)..(2182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2187)..(2188)
<223> Selenocysteine

<400> 4631
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Xaa Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Xaa Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Xaa Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Xaa Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Xaa Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Xaa Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Xaa Gly Ile Leu Ala Xaa Val Gly Xaa Glu Phe Asp Leu Arg 
            180                 185                 190         


Xaa Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Xaa Xaa Cys 
                245                 250                 255     


Phe Glu Glu Gly Xaa Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Xaa Glu Glu Pro Ala Arg Xaa Cys Pro Asn Gly Xaa Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Xaa Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp 
305                 310                 315                 320 


Xaa Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Xaa Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Xaa Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Gly Ala Leu Arg Arg Xaa Xaa Ile Lys Lys Ser Lys Xaa Asp 
            420                 425                 430         


Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser 
        435                 440                 445             


Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu 
    450                 455                 460                 


Asn Ser Xaa Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile 
465                 470                 475                 480 


Arg Arg Met Val Lys Xaa Gln Ala Phe Tyr Trp Xaa Val Leu Ser Leu 
                485                 490                 495     


Val Ala Leu Asn Xaa Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro 
            500                 505                 510         


Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly 
        515                 520                 525             


Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Xaa Arg 
    530                 535                 540                 


Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile 
545                 550                 555                 560 


Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Xaa Ser 
                565                 570                 575     


Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys 
            580                 585                 590         


Val Xaa Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu 
        595                 600                 605             


Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe 
    610                 615                 620                 


Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe 
625                 630                 635                 640 


Asn Phe Asp Glu Gly Xaa Pro Pro Xaa Asn Phe Asp Xaa Phe Pro Ala 
                645                 650                 655     


Ala Ile Met Xaa Val Phe Gln Ile Leu Xaa Gly Glu Asp Trp Asn Glu 
            660                 665                 670         


Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met 
        675                 680                 685             


Val Phe Ser Ile Tyr Phe Ile Val Leu Xaa Leu Phe Gly Asn Tyr Xaa 
    690                 695                 700                 


Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala 
705                 710                 715                 720 


Gln Glu Leu Xaa Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln 
                725                 730                 735     


Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu 
            740                 745                 750         


Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln 
        755                 760                 765             


Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Xaa Ser Glu Met Arg Lys 
    770                 775                 780                 


Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro 
785                 790                 795                 800 


Asp Glu Arg Trp Lys Ala Ala Tyr Xaa Arg His Leu Arg Pro Asp Met 
                805                 810                 815     


Lys Xaa His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg 
            820                 825                 830         


Asn Asn Asn Xaa Asn Lys Ser Arg Ala Ala Glu Pro Xaa Val Asp Gln 
        835                 840                 845             


Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg 
    850                 855                 860                 


Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala 
865                 870                 875                 880 


Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly 
                885                 890                 895     


Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu 
            900                 905                 910         


Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp 
        915                 920                 925             


Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg 
    930                 935                 940                 


Ser Gly Ser Pro Arg Xaa Gly Ala Asp Gly Glu His Arg Arg His Arg 
945                 950                 955                 960 


Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg 
                965                 970                 975     


Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly 
            980                 985                 990         


Glu Gly Glu Gly Pro Asp Gly Gly  Glu Arg Arg Arg Arg  His Arg His 
        995                 1000                 1005             


Gly Ala  Pro Ala Xaa Tyr Glu  Gly Asp Ala Arg Arg  Glu Asp Lys 
    1010                 1015                 1020             


Glu Arg  Arg His Arg Arg Arg  Lys Glu Asn Gln Gly  Ser Gly Val 
    1025                 1030                 1035             


Pro Val  Ser Gly Pro Asn Leu  Ser Xaa Xaa Arg Pro  Ile Gln Gln 
    1040                 1045                 1050             


Asp Leu  Gly Arg Gln Asp Pro  Pro Leu Ala Glu Asp  Ile Asp Asn 
    1055                 1060                 1065             


Met Lys  Asn Asn Lys Leu Ala  Xaa Ala Glu Ser Ala  Ala Pro His 
    1070                 1075                 1080             


Gly Ser  Leu Gly His Ala Gly  Leu Pro Gln Ser Pro  Ala Lys Met 
    1085                 1090                 1095             


Gly Asn  Ser Xaa Asp Pro Gly  Pro Met Leu Ala Ile  Pro Ala Met 
    1100                 1105                 1110             


Ala Xaa  Asn Pro Gln Asn Ala  Ala Ser Arg Arg Xaa  Pro Asn Asn 
    1115                 1120                 1125             


Pro Gly  Asn Pro Ser Asn Pro  Gly Pro Pro Lys Xaa  Pro Glu Asn 
    1130                 1135                 1140             


Ser Leu  Ile Val Xaa Asn Pro  Ser Gly Xaa Gln Xaa  Asn Ser Ala 
    1145                 1150                 1155             


Lys Xaa  Ala Arg Lys Pro Asp  His Xaa Xaa Val Asp  Ile Pro Pro 
    1160                 1165                 1170             


Ala Cys  Pro Pro Pro Leu Asn  His Xaa Val Val Gln  Val Asn Lys 
    1175                 1180                 1185             


Asn Ala  Asn Pro Asp Pro Leu  Pro Lys Lys Glu Glu  Glu Lys Lys 
    1190                 1195                 1200             


Glu Glu  Glu Glu Asp Asp Arg  Gly Glu Asp Gly Pro  Lys Pro Met 
    1205                 1210                 1215             


Pro Pro  Tyr Ser Ser Met Phe  Ile Leu Ser Xaa Xaa  Asn Pro Leu 
    1220                 1225                 1230             


Arg Arg  Leu Cys His Tyr Ile  Leu Asn Leu Arg Tyr  Phe Glu Met 
    1235                 1240                 1245             


Cys Ile  Leu Met Val Ile Ala  Met Ser Ser Ile Ala  Leu Ala Ala 
    1250                 1255                 1260             


Glu Asp  Pro Val Gln Pro Asn  Ala Pro Arg Asn Asn  Val Leu Arg 
    1265                 1270                 1275             


Tyr Phe  Asp Tyr Val Phe Xaa  Gly Val Phe Xaa Phe  Glu Met Val 
    1280                 1285                 1290             


Ile Lys  Met Ile Asp Leu Gly  Leu Val Leu His Gln  Gly Ala Tyr 
    1295                 1300                 1305             


Phe Arg  Asp Leu Trp Asn Ile  Leu Asp Phe Ile Val  Val Ser Gly 
    1310                 1315                 1320             


Ala Leu  Val Ala Phe Ala Phe  Xaa Gly Asn Ser Lys  Gly Lys Asp 
    1325                 1330                 1335             


Ile Asn  Xaa Ile Lys Ser Leu  Arg Val Leu Arg Val  Leu Arg Pro 
    1340                 1345                 1350             


Leu Lys  Xaa Ile Lys Arg Leu  Pro Lys Leu Lys Ala  Val Phe Asp 
    1355                 1360                 1365             


Cys Val  Val Asn Ser Leu Lys  Asn Val Phe Asn Ile  Leu Ile Val 
    1370                 1375                 1380             


Tyr Met  Leu Phe Met Phe Ile  Phe Ala Val Val Ala  Val Gln Leu 
    1385                 1390                 1395             


Phe Lys  Gly Lys Phe Phe His  Cys Xaa Asp Glu Ser  Lys Glu Phe 
    1400                 1405                 1410             


Glu Lys  Asp Cys Arg Gly Lys  Tyr Leu Leu Tyr Glu  Lys Asn Glu 
    1415                 1420                 1425             


Val Lys  Ala Arg Asp Arg Glu  Trp Lys Lys Tyr Glu  Phe His Tyr 
    1430                 1435                 1440             


Asp Asn  Val Leu Trp Ala Leu  Leu Xaa Leu Phe Xaa  Val Ser Xaa 
    1445                 1450                 1455             


Gly Glu  Gly Trp Pro Gln Val  Leu Lys His Ser Val  Asp Ala Xaa 
    1460                 1465                 1470             


Phe Glu  Asn Gln Gly Pro Ser  Pro Gly Tyr Arg Met  Glu Met Ser 
    1475                 1480                 1485             


Ile Phe  Tyr Val Val Tyr Phe  Val Val Phe Pro Phe  Phe Phe Val 
    1490                 1495                 1500             


Asn Ile  Phe Val Ala Leu Ile  Ile Ile Xaa Phe Gln  Glu Gln Gly 
    1505                 1510                 1515             


Asp Lys  Met Met Glu Glu Tyr  Ser Leu Glu Lys Asn  Glu Arg Ala 
    1520                 1525                 1530             


Cys Ile  Asp Phe Ala Ile Ser  Ala Lys Pro Leu Xaa  Arg His Met 
    1535                 1540                 1545             


Pro Gln  Asn Lys Gln Ser Phe  Gln Tyr Arg Met Trp  Gln Phe Val 
    1550                 1555                 1560             


Val Ser  Pro Pro Phe Glu Tyr  Xaa Ile Met Ala Met  Ile Ala Leu 
    1565                 1570                 1575             


Asn Xaa  Ile Val Leu Met Met  Lys Phe Tyr Gly Ala  Ser Val Ala 
    1580                 1585                 1590             


Tyr Glu  Asn Ala Leu Arg Val  Phe Asn Ile Val Phe  Xaa Ser Leu 
    1595                 1600                 1605             


Phe Ser  Leu Glu Cys Val Leu  Lys Val Met Ala Phe  Gly Ile Leu 
    1610                 1615                 1620             


Asn Tyr  Phe Arg Asp Ala Trp  Asn Ile Phe Asp Phe  Val Xaa Val 
    1625                 1630                 1635             


Leu Gly  Ser Ile Xaa Asp Ile  Leu Val Xaa Glu Phe  Gly Asn Pro 
    1640                 1645                 1650             


Asn Asn  Phe Ile Asn Leu Ser  Phe Leu Arg Leu Phe  Arg Ala Ala 
    1655                 1660                 1665             


Arg Leu  Ile Lys Leu Leu Arg  Gln Gly Tyr Xaa Ile  Arg Ile Leu 
    1670                 1675                 1680             


Leu Trp  Xaa Phe Val Gln Ser  Phe Lys Ala Leu Pro  Tyr Val Cys 
    1685                 1690                 1695             


Leu Leu  Ile Ala Met Leu Phe  Phe Ile Tyr Ala Ile  Ile Gly Met 
    1700                 1705                 1710             


Gln Val  Phe Gly Asn Ile Gly  Ile Asp Val Glu Asp  Glu Asp Ser 
    1715                 1720                 1725             


Asp Glu  Asp Glu Phe Gln Ile  Xaa Glu His Asn Asn  Phe Arg Xaa 
    1730                 1735                 1740             


Phe Phe  Gln Ala Leu Met Leu  Leu Phe Arg Ser Ala  Xaa Gly Glu 
    1745                 1750                 1755             


Ala Trp  His Asn Ile Met Leu  Ser Cys Leu Ser Gly  Lys Pro Cys 
    1760                 1765                 1770             


Asp Lys  Asn Ser Gly Ile Leu  Xaa Arg Glu Cys Gly  Asn Glu Phe 
    1775                 1780                 1785             


Ala Tyr  Phe Tyr Phe Val Ser  Phe Ile Phe Leu Cys  Ser Phe Leu 
    1790                 1795                 1800             


Met Leu  Asn Leu Phe Val Ala  Val Ile Met Asp Asn  Phe Glu Tyr 
    1805                 1810                 1815             


Leu Xaa  Arg Asp Ser Ser Ile  Leu Gly Pro His His  Leu Asp Glu 
    1820                 1825                 1830             


Tyr Val  Arg Val Trp Ala Glu  Tyr Asp Pro Ala Ala  Trp Gly Arg 
    1835                 1840                 1845             


Met Pro  Tyr Leu Asp Met Tyr  Gln Met Leu Arg His  Met Ser Pro 
    1850                 1855                 1860             


Pro Leu  Gly Leu Gly Lys Lys  Cys Pro Ala Arg Val  Ala Tyr Lys 
    1865                 1870                 1875             


Arg Leu  Leu Arg Met Asp Leu  Pro Val Ala Asp Asp  Asn Xaa Val 
    1880                 1885                 1890             


His Phe  Asn Ser Xaa Leu Met  Ala Leu Ile Arg Xaa  Ala Leu Asp 
    1895                 1900                 1905             


Ile Lys  Ile Ala Lys Gly Gly  Ala Asp Lys Gln Gln  Met Asp Ala 
    1910                 1915                 1920             


Glu Leu  Arg Lys Glu Met Met  Ala Ile Trp Pro Asn  Leu Ser Gln 
    1925                 1930                 1935             


Lys Xaa  Leu Asp Leu Leu Val  Xaa Pro His Lys Ser  Xaa Asp Leu 
    1940                 1945                 1950             


Xaa Val  Gly Lys Ile Tyr Ala  Ala Met Met Ile Met  Glu Tyr Tyr 
    1955                 1960                 1965             


Arg Gln  Ser Lys Ala Lys Lys  Leu Gln Ala Met Arg  Glu Glu Gln 
    1970                 1975                 1980             


Asp Arg  Xaa Pro Leu Met Phe  Gln Arg Met Glu Pro  Pro Ser Pro 
    1985                 1990                 1995             


Xaa Gln  Glu Gly Gly Pro Gly  Gln Asn Ala Leu Pro  Ser Xaa Gln 
    2000                 2005                 2010             


Leu Asp  Pro Gly Gly Ala Leu  Met Ala His Glu Ser  Gly Leu Lys 
    2015                 2020                 2025             


Glu Ser  Pro Ser Trp Val Xaa  Gln Arg Ala Gln Glu  Met Phe Gln 
    2030                 2035                 2040             


Lys Xaa  Gly Xaa Trp Ser Pro  Glu Gln Gly Pro Pro  Xaa Asp Met 
    2045                 2050                 2055             


Pro Asn  Ser Gln Pro Asn Ser  Gln Ser Val Glu Met  Arg Glu Met 
    2060                 2065                 2070             


Gly Arg  Asp Gly Tyr Ser Asp  Ser Glu His Tyr Leu  Pro Met Glu 
    2075                 2080                 2085             


Gly Gln  Gly Arg Ala Ala Ser  Met Pro Arg Leu Pro  Ala Glu Asn 
    2090                 2095                 2100             


Gln Arg  Arg Arg Gly Arg Pro  Arg Gly Asn Asn Leu  Ser Xaa Ile 
    2105                 2110                 2115             


Ser Asp  Xaa Ser Pro Met Lys  Arg Ser Ala Ser Val  Leu Gly Pro 
    2120                 2125                 2130             


Lys Ala  Arg Arg Leu Asp Asp  Tyr Ser Leu Glu Arg  Val Pro Pro 
    2135                 2140                 2145             


Glu Glu  Asn Gln Arg His His  Gln Arg Arg Arg Asp  Arg Ser His 
    2150                 2155                 2160             


Arg Ala  Ser Glu Arg Ser Leu  Gly Arg Tyr Xaa Asp  Val Asp Xaa 
    2165                 2170                 2175             


Gly Leu  Gly Xaa Asp Leu Ser  Met Xaa Xaa Gln Ser  Gly Asp Leu 
    2180                 2185                 2190             


Pro Ser  Lys Glu Arg Asp Gln  Glu Arg Gly Arg Pro  Lys Asp Arg 
    2195                 2200                 2205             


Lys His  Arg Gln His His His  His His His His His  His His Pro 
    2210                 2215                 2220             


Pro Pro  Pro Asp Lys Asp Arg  Tyr Ala Gln Glu Arg  Pro Asp His 
    2225                 2230                 2235             


Gly Arg  Ala Arg Ala Arg Asp  Gln Arg Trp Ser Arg  Ser Pro Ser 
    2240                 2245                 2250             


Glu Gly  Arg Glu His Met Ala  His Arg Gln 
    2255                 2260             


<210> 4632
<211> 2266
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1105)..(1105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1128)..(1128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1344)..(1344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1359)..(1359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1410)..(1410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1461)..(1461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1476)..(1476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1516)..(1516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1548)..(1548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1583)..(1583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1651)..(1651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1682)..(1682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1689)..(1689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1739)..(1739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1746)..(1746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1759)..(1759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1784)..(1784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1823)..(1823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1895)..(1895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1901)..(1901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1908)..(1908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1943)..(1943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1949)..(1949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1954)..(1954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1957)..(1957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1989)..(1989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2002)..(2002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2015)..(2015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2038)..(2038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2048)..(2048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2050)..(2050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2059)..(2059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2120)..(2120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2124)..(2124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2177)..(2177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2181)..(2181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2185)..(2185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2190)..(2191)
<223> Selenocysteine

<400> 4632
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Xaa Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Xaa Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Xaa Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Xaa Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Xaa Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Xaa Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Xaa Gly Ile Leu Ala Xaa Val Gly Xaa Glu Phe Asp Leu Arg 
            180                 185                 190         


Xaa Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Xaa Xaa Cys 
                245                 250                 255     


Phe Glu Glu Gly Xaa Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Xaa Glu Glu Pro Ala Arg Xaa Cys Pro Asn Gly Xaa Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Xaa Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp 
305                 310                 315                 320 


Xaa Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Xaa Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Xaa Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Gly Ala Leu Arg Arg Xaa Xaa Ile Lys Lys Ser Lys Xaa Asp 
            420                 425                 430         


Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser 
        435                 440                 445             


Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu 
    450                 455                 460                 


Asn Ser Xaa Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile 
465                 470                 475                 480 


Arg Arg Met Val Lys Xaa Gln Ala Phe Tyr Trp Xaa Val Leu Ser Leu 
                485                 490                 495     


Val Ala Leu Asn Xaa Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro 
            500                 505                 510         


Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly 
        515                 520                 525             


Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Xaa Arg 
    530                 535                 540                 


Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile 
545                 550                 555                 560 


Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Xaa Ser 
                565                 570                 575     


Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys 
            580                 585                 590         


Val Xaa Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu 
        595                 600                 605             


Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe 
    610                 615                 620                 


Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe 
625                 630                 635                 640 


Asn Phe Asp Glu Gly Xaa Pro Pro Xaa Asn Phe Asp Xaa Phe Pro Ala 
                645                 650                 655     


Ala Ile Met Xaa Val Phe Gln Ile Leu Xaa Gly Glu Asp Trp Asn Glu 
            660                 665                 670         


Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met 
        675                 680                 685             


Val Phe Ser Ile Tyr Phe Ile Val Leu Xaa Leu Phe Gly Asn Tyr Xaa 
    690                 695                 700                 


Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala 
705                 710                 715                 720 


Gln Glu Leu Xaa Lys Val Glu Ala Asp Glu Gln Glu Glu Glu Glu Ala 
                725                 730                 735     


Ala Asn Gln Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val 
            740                 745                 750         


Ser Pro Leu Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln 
        755                 760                 765             


Lys Asn Gln Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Xaa Ser Glu 
    770                 775                 780                 


Met Arg Lys Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu 
785                 790                 795                 800 


Met Asp Pro Asp Glu Arg Trp Lys Ala Ala Tyr Xaa Arg His Leu Arg 
                805                 810                 815     


Pro Asp Met Lys Xaa His Leu Asp Arg Pro Leu Val Val Asp Pro Gln 
            820                 825                 830         


Glu Asn Arg Asn Asn Asn Xaa Asn Lys Ser Arg Ala Ala Glu Pro Xaa 
        835                 840                 845             


Val Asp Gln Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys 
    850                 855                 860                 


Gln Ala Arg Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly 
865                 870                 875                 880 


Leu Asp Ala Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser 
                885                 890                 895     


Arg Glu Gly Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly 
            900                 905                 910         


Ser Leu Glu Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys 
        915                 920                 925             


Ala Gly Asp Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg 
    930                 935                 940                 


Glu Ser Arg Ser Gly Ser Pro Arg Xaa Gly Ala Asp Gly Glu His Arg 
945                 950                 955                 960 


Arg His Arg Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys 
                965                 970                 975     


Ala Glu Arg Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly 
            980                 985                 990         


Gly Glu Gly Glu Gly Glu Gly Pro  Asp Gly Gly Glu Arg  Arg Arg Arg 
        995                 1000                 1005             


His Arg  His Gly Ala Pro Ala  Xaa Tyr Glu Gly Asp  Ala Arg Arg 
    1010                 1015                 1020             


Glu Asp  Lys Glu Arg Arg His  Arg Arg Arg Lys Glu  Asn Gln Gly 
    1025                 1030                 1035             


Ser Gly  Val Pro Val Ser Gly  Pro Asn Leu Ser Xaa  Xaa Arg Pro 
    1040                 1045                 1050             


Ile Gln  Gln Asp Leu Gly Arg  Gln Asp Pro Pro Leu  Ala Glu Asp 
    1055                 1060                 1065             


Ile Asp  Asn Met Lys Asn Asn  Lys Leu Ala Xaa Ala  Glu Ser Ala 
    1070                 1075                 1080             


Ala Pro  His Gly Ser Leu Gly  His Ala Gly Leu Pro  Gln Ser Pro 
    1085                 1090                 1095             


Ala Lys  Met Gly Asn Ser Xaa  Asp Pro Gly Pro Met  Leu Ala Ile 
    1100                 1105                 1110             


Pro Ala  Met Ala Xaa Asn Pro  Gln Asn Ala Ala Ser  Arg Arg Xaa 
    1115                 1120                 1125             


Pro Asn  Asn Pro Gly Asn Pro  Ser Asn Pro Gly Pro  Pro Lys Xaa 
    1130                 1135                 1140             


Pro Glu  Asn Ser Leu Ile Val  Xaa Asn Pro Ser Gly  Xaa Gln Xaa 
    1145                 1150                 1155             


Asn Ser  Ala Lys Xaa Ala Arg  Lys Pro Asp His Xaa  Xaa Val Asp 
    1160                 1165                 1170             


Ile Pro  Pro Ala Cys Pro Pro  Pro Leu Asn His Xaa  Val Val Gln 
    1175                 1180                 1185             


Val Asn  Lys Asn Ala Asn Pro  Asp Pro Leu Pro Lys  Lys Glu Glu 
    1190                 1195                 1200             


Glu Lys  Lys Glu Glu Glu Glu  Asp Asp Arg Gly Glu  Asp Gly Pro 
    1205                 1210                 1215             


Lys Pro  Met Pro Pro Tyr Ser  Ser Met Phe Ile Leu  Ser Xaa Xaa 
    1220                 1225                 1230             


Asn Pro  Leu Arg Arg Leu Cys  His Tyr Ile Leu Asn  Leu Arg Tyr 
    1235                 1240                 1245             


Phe Glu  Met Cys Ile Leu Met  Val Ile Ala Met Ser  Ser Ile Ala 
    1250                 1255                 1260             


Leu Ala  Ala Glu Asp Pro Val  Gln Pro Asn Ala Pro  Arg Asn Asn 
    1265                 1270                 1275             


Val Leu  Arg Tyr Phe Asp Tyr  Val Phe Xaa Gly Val  Phe Xaa Phe 
    1280                 1285                 1290             


Glu Met  Val Ile Lys Met Ile  Asp Leu Gly Leu Val  Leu His Gln 
    1295                 1300                 1305             


Gly Ala  Tyr Phe Arg Asp Leu  Trp Asn Ile Leu Asp  Phe Ile Val 
    1310                 1315                 1320             


Val Ser  Gly Ala Leu Val Ala  Phe Ala Phe Xaa Gly  Asn Ser Lys 
    1325                 1330                 1335             


Gly Lys  Asp Ile Asn Xaa Ile  Lys Ser Leu Arg Val  Leu Arg Val 
    1340                 1345                 1350             


Leu Arg  Pro Leu Lys Xaa Ile  Lys Arg Leu Pro Lys  Leu Lys Ala 
    1355                 1360                 1365             


Val Phe  Asp Cys Val Val Asn  Ser Leu Lys Asn Val  Phe Asn Ile 
    1370                 1375                 1380             


Leu Ile  Val Tyr Met Leu Phe  Met Phe Ile Phe Ala  Val Val Ala 
    1385                 1390                 1395             


Val Gln  Leu Phe Lys Gly Lys  Phe Phe His Cys Xaa  Asp Glu Ser 
    1400                 1405                 1410             


Lys Glu  Phe Glu Lys Asp Cys  Arg Gly Lys Tyr Leu  Leu Tyr Glu 
    1415                 1420                 1425             


Lys Asn  Glu Val Lys Ala Arg  Asp Arg Glu Trp Lys  Lys Tyr Glu 
    1430                 1435                 1440             


Phe His  Tyr Asp Asn Val Leu  Trp Ala Leu Leu Xaa  Leu Phe Xaa 
    1445                 1450                 1455             


Val Ser  Xaa Gly Glu Gly Trp  Pro Gln Val Leu Lys  His Ser Val 
    1460                 1465                 1470             


Asp Ala  Xaa Phe Glu Asn Gln  Gly Pro Ser Pro Gly  Tyr Arg Met 
    1475                 1480                 1485             


Glu Met  Ser Ile Phe Tyr Val  Val Tyr Phe Val Val  Phe Pro Phe 
    1490                 1495                 1500             


Phe Phe  Val Asn Ile Phe Val  Ala Leu Ile Ile Ile  Xaa Phe Gln 
    1505                 1510                 1515             


Glu Gln  Gly Asp Lys Met Met  Glu Glu Tyr Ser Leu  Glu Lys Asn 
    1520                 1525                 1530             


Glu Arg  Ala Cys Ile Asp Phe  Ala Ile Ser Ala Lys  Pro Leu Xaa 
    1535                 1540                 1545             


Arg His  Met Pro Gln Asn Lys  Gln Ser Phe Gln Tyr  Arg Met Trp 
    1550                 1555                 1560             


Gln Phe  Val Val Ser Pro Pro  Phe Glu Tyr Xaa Ile  Met Ala Met 
    1565                 1570                 1575             


Ile Ala  Leu Asn Xaa Ile Val  Leu Met Met Lys Phe  Tyr Gly Ala 
    1580                 1585                 1590             


Ser Val  Ala Tyr Glu Asn Ala  Leu Arg Val Phe Asn  Ile Val Phe 
    1595                 1600                 1605             


Xaa Ser  Leu Phe Ser Leu Glu  Cys Val Leu Lys Val  Met Ala Phe 
    1610                 1615                 1620             


Gly Ile  Leu Asn Tyr Phe Arg  Asp Ala Trp Asn Ile  Phe Asp Phe 
    1625                 1630                 1635             


Val Xaa  Val Leu Gly Ser Ile  Xaa Asp Ile Leu Val  Xaa Glu Phe 
    1640                 1645                 1650             


Gly Asn  Pro Asn Asn Phe Ile  Asn Leu Ser Phe Leu  Arg Leu Phe 
    1655                 1660                 1665             


Arg Ala  Ala Arg Leu Ile Lys  Leu Leu Arg Gln Gly  Tyr Xaa Ile 
    1670                 1675                 1680             


Arg Ile  Leu Leu Trp Xaa Phe  Val Gln Ser Phe Lys  Ala Leu Pro 
    1685                 1690                 1695             


Tyr Val  Cys Leu Leu Ile Ala  Met Leu Phe Phe Ile  Tyr Ala Ile 
    1700                 1705                 1710             


Ile Gly  Met Gln Val Phe Gly  Asn Ile Gly Ile Asp  Val Glu Asp 
    1715                 1720                 1725             


Glu Asp  Ser Asp Glu Asp Glu  Phe Gln Ile Xaa Glu  His Asn Asn 
    1730                 1735                 1740             


Phe Arg  Xaa Phe Phe Gln Ala  Leu Met Leu Leu Phe  Arg Ser Ala 
    1745                 1750                 1755             


Xaa Gly  Glu Ala Trp His Asn  Ile Met Leu Ser Cys  Leu Ser Gly 
    1760                 1765                 1770             


Lys Pro  Cys Asp Lys Asn Ser  Gly Ile Leu Xaa Arg  Glu Cys Gly 
    1775                 1780                 1785             


Asn Glu  Phe Ala Tyr Phe Tyr  Phe Val Ser Phe Ile  Phe Leu Cys 
    1790                 1795                 1800             


Ser Phe  Leu Met Leu Asn Leu  Phe Val Ala Val Ile  Met Asp Asn 
    1805                 1810                 1815             


Phe Glu  Tyr Leu Xaa Arg Asp  Ser Ser Ile Leu Gly  Pro His His 
    1820                 1825                 1830             


Leu Asp  Glu Tyr Val Arg Val  Trp Ala Glu Tyr Asp  Pro Ala Ala 
    1835                 1840                 1845             


Trp Gly  Arg Met Pro Tyr Leu  Asp Met Tyr Gln Met  Leu Arg His 
    1850                 1855                 1860             


Met Ser  Pro Pro Leu Gly Leu  Gly Lys Lys Cys Pro  Ala Arg Val 
    1865                 1870                 1875             


Ala Tyr  Lys Arg Leu Leu Arg  Met Asp Leu Pro Val  Ala Asp Asp 
    1880                 1885                 1890             


Asn Xaa  Val His Phe Asn Ser  Xaa Leu Met Ala Leu  Ile Arg Xaa 
    1895                 1900                 1905             


Ala Leu  Asp Ile Lys Ile Ala  Lys Gly Gly Ala Asp  Lys Gln Gln 
    1910                 1915                 1920             


Met Asp  Ala Glu Leu Arg Lys  Glu Met Met Ala Ile  Trp Pro Asn 
    1925                 1930                 1935             


Leu Ser  Gln Lys Xaa Leu Asp  Leu Leu Val Xaa Pro  His Lys Ser 
    1940                 1945                 1950             


Xaa Asp  Leu Xaa Val Gly Lys  Ile Tyr Ala Ala Met  Met Ile Met 
    1955                 1960                 1965             


Glu Tyr  Tyr Arg Gln Ser Lys  Ala Lys Lys Leu Gln  Ala Met Arg 
    1970                 1975                 1980             


Glu Glu  Gln Asp Arg Xaa Pro  Leu Met Phe Gln Arg  Met Glu Pro 
    1985                 1990                 1995             


Pro Ser  Pro Xaa Gln Glu Gly  Gly Pro Gly Gln Asn  Ala Leu Pro 
    2000                 2005                 2010             


Ser Xaa  Gln Leu Asp Pro Gly  Gly Ala Leu Met Ala  His Glu Ser 
    2015                 2020                 2025             


Gly Leu  Lys Glu Ser Pro Ser  Trp Val Xaa Gln Arg  Ala Gln Glu 
    2030                 2035                 2040             


Met Phe  Gln Lys Xaa Gly Xaa  Trp Ser Pro Glu Gln  Gly Pro Pro 
    2045                 2050                 2055             


Xaa Asp  Met Pro Asn Ser Gln  Pro Asn Ser Gln Ser  Val Glu Met 
    2060                 2065                 2070             


Arg Glu  Met Gly Arg Asp Gly  Tyr Ser Asp Ser Glu  His Tyr Leu 
    2075                 2080                 2085             


Pro Met  Glu Gly Gln Gly Arg  Ala Ala Ser Met Pro  Arg Leu Pro 
    2090                 2095                 2100             


Ala Glu  Asn Gln Arg Arg Arg  Gly Arg Pro Arg Gly  Asn Asn Leu 
    2105                 2110                 2115             


Ser Xaa  Ile Ser Asp Xaa Ser  Pro Met Lys Arg Ser  Ala Ser Val 
    2120                 2125                 2130             


Leu Gly  Pro Lys Ala Arg Arg  Leu Asp Asp Tyr Ser  Leu Glu Arg 
    2135                 2140                 2145             


Val Pro  Pro Glu Glu Asn Gln  Arg His His Gln Arg  Arg Arg Asp 
    2150                 2155                 2160             


Arg Ser  His Arg Ala Ser Glu  Arg Ser Leu Gly Arg  Tyr Xaa Asp 
    2165                 2170                 2175             


Val Asp  Xaa Gly Leu Gly Xaa  Asp Leu Ser Met Xaa  Xaa Gln Ser 
    2180                 2185                 2190             


Gly Asp  Leu Pro Ser Lys Glu  Arg Asp Gln Glu Arg  Gly Arg Pro 
    2195                 2200                 2205             


Lys Asp  Arg Lys His Arg Gln  His His His His His  His His His 
    2210                 2215                 2220             


His His  Pro Pro Pro Pro Asp  Lys Asp Arg Tyr Ala  Gln Glu Arg 
    2225                 2230                 2235             


Pro Asp  His Gly Arg Ala Arg  Ala Arg Asp Gln Arg  Trp Ser Arg 
    2240                 2245                 2250             


Ser Pro  Ser Glu Gly Arg Glu  His Met Ala His Arg  Gln 
    2255                 2260                 2265     


<210> 4633
<211> 2302
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1356)..(1356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1452)..(1452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1571)..(1571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1580)..(1580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1637)..(1637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1643)..(1643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1648)..(1648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1677)..(1677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1684)..(1684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1734)..(1734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1741)..(1741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1779)..(1779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1818)..(1818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1890)..(1890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1896)..(1896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1903)..(1903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1938)..(1938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1944)..(1944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1949)..(1949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1952)..(1952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1984)..(1984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1997)..(1997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2010)..(2010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2033)..(2033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2043)..(2043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2045)..(2045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2054)..(2054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2115)..(2115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2119)..(2119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2172)..(2172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2176)..(2176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2180)..(2180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2185)..(2186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2294)..(2294)
<223> Selenocysteine

<400> 4633
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Xaa Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Xaa Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Xaa Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Xaa Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Xaa Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Xaa Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Xaa Gly Ile Leu Ala Xaa Val Gly Xaa Glu Phe Asp Leu Arg 
            180                 185                 190         


Xaa Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Xaa Xaa Cys 
                245                 250                 255     


Phe Glu Glu Gly Xaa Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Xaa Glu Glu Pro Ala Arg Xaa Cys Pro Asn Gly Xaa Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Xaa Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp 
305                 310                 315                 320 


Xaa Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Xaa Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Xaa Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Gly Ala Leu Arg Arg Xaa Xaa Ile Lys Lys Ser Lys Xaa Asp 
            420                 425                 430         


Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser 
        435                 440                 445             


Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu 
    450                 455                 460                 


Asn Ser Xaa Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile 
465                 470                 475                 480 


Arg Arg Met Val Lys Xaa Gln Ala Phe Tyr Trp Xaa Val Leu Ser Leu 
                485                 490                 495     


Val Ala Leu Asn Xaa Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro 
            500                 505                 510         


Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly 
        515                 520                 525             


Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Xaa Arg 
    530                 535                 540                 


Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile 
545                 550                 555                 560 


Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Xaa Ser 
                565                 570                 575     


Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys 
            580                 585                 590         


Val Xaa Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu 
        595                 600                 605             


Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe 
    610                 615                 620                 


Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe 
625                 630                 635                 640 


Asn Phe Asp Glu Gly Xaa Pro Pro Xaa Asn Phe Asp Xaa Phe Pro Ala 
                645                 650                 655     


Ala Ile Met Xaa Val Phe Gln Ile Leu Xaa Gly Glu Asp Trp Asn Glu 
            660                 665                 670         


Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met 
        675                 680                 685             


Val Phe Ser Ile Tyr Phe Ile Val Leu Xaa Leu Phe Gly Asn Tyr Xaa 
    690                 695                 700                 


Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala 
705                 710                 715                 720 


Gln Glu Leu Xaa Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln 
                725                 730                 735     


Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu 
            740                 745                 750         


Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln 
        755                 760                 765             


Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Xaa Ser Glu Met Arg Lys 
    770                 775                 780                 


Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro 
785                 790                 795                 800 


Asp Glu Arg Trp Lys Ala Ala Tyr Xaa Arg His Leu Arg Pro Asp Met 
                805                 810                 815     


Lys Xaa His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg 
            820                 825                 830         


Asn Asn Asn Xaa Asn Lys Ser Arg Ala Ala Glu Pro Xaa Val Asp Gln 
        835                 840                 845             


Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg 
    850                 855                 860                 


Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala 
865                 870                 875                 880 


Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly 
                885                 890                 895     


Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu 
            900                 905                 910         


Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp 
        915                 920                 925             


Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg 
    930                 935                 940                 


Ser Gly Ser Pro Arg Xaa Gly Ala Asp Gly Glu His Arg Arg His Arg 
945                 950                 955                 960 


Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg 
                965                 970                 975     


Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly 
            980                 985                 990         


Glu Gly Glu Gly Pro Asp Gly Gly  Glu Arg Arg Arg Arg  His Arg His 
        995                 1000                 1005             


Gly Ala  Pro Ala Xaa Tyr Glu  Gly Asp Ala Arg Arg  Glu Asp Lys 
    1010                 1015                 1020             


Glu Arg  Arg His Arg Arg Arg  Lys Glu Asn Gln Gly  Ser Gly Val 
    1025                 1030                 1035             


Pro Val  Ser Gly Pro Asn Leu  Ser Xaa Xaa Arg Pro  Ile Gln Gln 
    1040                 1045                 1050             


Asp Leu  Gly Arg Gln Asp Pro  Pro Leu Ala Glu Asp  Ile Asp Asn 
    1055                 1060                 1065             


Met Lys  Asn Asn Lys Leu Ala  Xaa Ala Glu Ser Ala  Ala Pro His 
    1070                 1075                 1080             


Gly Ser  Leu Gly His Ala Gly  Leu Pro Gln Ser Pro  Ala Lys Met 
    1085                 1090                 1095             


Gly Asn  Ser Xaa Asp Pro Gly  Pro Met Leu Ala Ile  Pro Ala Met 
    1100                 1105                 1110             


Ala Xaa  Asn Pro Gln Asn Ala  Ala Ser Arg Arg Xaa  Pro Asn Asn 
    1115                 1120                 1125             


Pro Gly  Asn Pro Ser Asn Pro  Gly Pro Pro Lys Xaa  Pro Glu Asn 
    1130                 1135                 1140             


Ser Leu  Ile Val Xaa Asn Pro  Ser Gly Xaa Gln Xaa  Asn Ser Ala 
    1145                 1150                 1155             


Lys Xaa  Ala Arg Lys Pro Asp  His Xaa Xaa Val Asp  Ile Pro Pro 
    1160                 1165                 1170             


Ala Cys  Pro Pro Pro Leu Asn  His Xaa Val Val Gln  Val Asn Lys 
    1175                 1180                 1185             


Asn Ala  Asn Pro Asp Pro Leu  Pro Lys Lys Glu Glu  Glu Lys Lys 
    1190                 1195                 1200             


Glu Glu  Glu Glu Asp Asp Arg  Gly Glu Asp Gly Pro  Lys Pro Met 
    1205                 1210                 1215             


Pro Pro  Tyr Ser Ser Met Phe  Ile Leu Ser Xaa Xaa  Asn Pro Leu 
    1220                 1225                 1230             


Arg Arg  Leu Cys His Tyr Ile  Leu Asn Leu Arg Tyr  Phe Glu Met 
    1235                 1240                 1245             


Cys Ile  Leu Met Val Ile Ala  Met Ser Ser Ile Ala  Leu Ala Ala 
    1250                 1255                 1260             


Glu Asp  Pro Val Gln Pro Asn  Ala Pro Arg Asn Asn  Val Leu Arg 
    1265                 1270                 1275             


Tyr Phe  Asp Tyr Val Phe Xaa  Gly Val Phe Xaa Phe  Glu Met Val 
    1280                 1285                 1290             


Ile Lys  Met Ile Asp Leu Gly  Leu Val Leu His Gln  Gly Ala Tyr 
    1295                 1300                 1305             


Phe Arg  Asp Leu Trp Asn Ile  Leu Asp Phe Ile Val  Val Ser Gly 
    1310                 1315                 1320             


Ala Leu  Val Ala Phe Ala Phe  Xaa Gly Asn Ser Lys  Gly Lys Asp 
    1325                 1330                 1335             


Ile Asn  Xaa Ile Lys Ser Leu  Arg Val Leu Arg Val  Leu Arg Pro 
    1340                 1345                 1350             


Leu Lys  Xaa Ile Lys Arg Leu  Pro Lys Leu Lys Ala  Val Phe Asp 
    1355                 1360                 1365             


Cys Val  Val Asn Ser Leu Lys  Asn Val Phe Asn Ile  Leu Ile Val 
    1370                 1375                 1380             


Tyr Met  Leu Phe Met Phe Ile  Phe Ala Val Val Ala  Val Gln Leu 
    1385                 1390                 1395             


Phe Lys  Gly Lys Phe Phe His  Cys Xaa Asp Glu Ser  Lys Glu Phe 
    1400                 1405                 1410             


Glu Lys  Asp Cys Arg Gly Lys  Tyr Leu Leu Tyr Glu  Lys Asn Glu 
    1415                 1420                 1425             


Val Lys  Ala Arg Asp Arg Glu  Trp Lys Lys Tyr Glu  Phe His Tyr 
    1430                 1435                 1440             


Asp Asn  Val Leu Trp Ala Leu  Leu Xaa Leu Phe Xaa  Val Ser Xaa 
    1445                 1450                 1455             


Gly Glu  Gly Trp Pro Gln Val  Leu Lys His Ser Val  Asp Ala Xaa 
    1460                 1465                 1470             


Phe Glu  Asn Gln Gly Pro Ser  Pro Gly Tyr Arg Met  Glu Met Ser 
    1475                 1480                 1485             


Ile Phe  Tyr Val Val Tyr Phe  Val Val Phe Pro Phe  Phe Phe Val 
    1490                 1495                 1500             


Asn Ile  Phe Val Ala Leu Ile  Ile Ile Xaa Phe Gln  Glu Gln Gly 
    1505                 1510                 1515             


Asp Lys  Met Met Glu Glu Tyr  Ser Leu Glu Lys Asn  Glu Arg Ala 
    1520                 1525                 1530             


Cys Ile  Asp Phe Ala Ile Ser  Ala Lys Pro Leu Xaa  Arg His Met 
    1535                 1540                 1545             


Pro Gln  Asn Lys Gln Ser Phe  Gln Tyr Arg Met Trp  Gln Phe Val 
    1550                 1555                 1560             


Val Ser  Pro Pro Phe Glu Tyr  Xaa Ile Met Ala Met  Ile Ala Leu 
    1565                 1570                 1575             


Asn Xaa  Ile Val Leu Met Met  Lys Phe Tyr Gly Ala  Ser Val Ala 
    1580                 1585                 1590             


Tyr Glu  Asn Ala Leu Arg Val  Phe Asn Ile Val Phe  Xaa Ser Leu 
    1595                 1600                 1605             


Phe Ser  Leu Glu Cys Val Leu  Lys Val Met Ala Phe  Gly Ile Leu 
    1610                 1615                 1620             


Asn Tyr  Phe Arg Asp Ala Trp  Asn Ile Phe Asp Phe  Val Xaa Val 
    1625                 1630                 1635             


Leu Gly  Ser Ile Xaa Asp Ile  Leu Val Xaa Glu Phe  Gly Asn Asn 
    1640                 1645                 1650             


Phe Ile  Asn Leu Ser Phe Leu  Arg Leu Phe Arg Ala  Ala Arg Leu 
    1655                 1660                 1665             


Ile Lys  Leu Leu Arg Gln Gly  Tyr Xaa Ile Arg Ile  Leu Leu Trp 
    1670                 1675                 1680             


Xaa Phe  Val Gln Ser Phe Lys  Ala Leu Pro Tyr Val  Cys Leu Leu 
    1685                 1690                 1695             


Ile Ala  Met Leu Phe Phe Ile  Tyr Ala Ile Ile Gly  Met Gln Val 
    1700                 1705                 1710             


Phe Gly  Asn Ile Gly Ile Asp  Val Glu Asp Glu Asp  Ser Asp Glu 
    1715                 1720                 1725             


Asp Glu  Phe Gln Ile Xaa Glu  His Asn Asn Phe Arg  Xaa Phe Phe 
    1730                 1735                 1740             


Gln Ala  Leu Met Leu Leu Phe  Arg Ser Ala Xaa Gly  Glu Ala Trp 
    1745                 1750                 1755             


His Asn  Ile Met Leu Ser Cys  Leu Ser Gly Lys Pro  Cys Asp Lys 
    1760                 1765                 1770             


Asn Ser  Gly Ile Leu Xaa Arg  Glu Cys Gly Asn Glu  Phe Ala Tyr 
    1775                 1780                 1785             


Phe Tyr  Phe Val Ser Phe Ile  Phe Leu Cys Ser Phe  Leu Met Leu 
    1790                 1795                 1800             


Asn Leu  Phe Val Ala Val Ile  Met Asp Asn Phe Glu  Tyr Leu Xaa 
    1805                 1810                 1815             


Arg Asp  Ser Ser Ile Leu Gly  Pro His His Leu Asp  Glu Tyr Val 
    1820                 1825                 1830             


Arg Val  Trp Ala Glu Tyr Asp  Pro Ala Ala Cys Gly  Arg Ile His 
    1835                 1840                 1845             


Tyr Lys  Asp Met Tyr Ser Leu  Leu Arg Val Ile Ser  Pro Pro Leu 
    1850                 1855                 1860             


Gly Leu  Gly Lys Lys Cys Pro  His Arg Val Ala Cys  Lys Arg Leu 
    1865                 1870                 1875             


Leu Arg  Met Asp Leu Pro Val  Ala Asp Asp Asn Xaa  Val His Phe 
    1880                 1885                 1890             


Asn Ser  Xaa Leu Met Ala Leu  Ile Arg Xaa Ala Leu  Asp Ile Lys 
    1895                 1900                 1905             


Ile Ala  Lys Gly Gly Ala Asp  Lys Gln Gln Met Asp  Ala Glu Leu 
    1910                 1915                 1920             


Arg Lys  Glu Met Met Ala Ile  Trp Pro Asn Leu Ser  Gln Lys Xaa 
    1925                 1930                 1935             


Leu Asp  Leu Leu Val Xaa Pro  His Lys Ser Xaa Asp  Leu Xaa Val 
    1940                 1945                 1950             


Gly Lys  Ile Tyr Ala Ala Met  Met Ile Met Glu Tyr  Tyr Arg Gln 
    1955                 1960                 1965             


Ser Lys  Ala Lys Lys Leu Gln  Ala Met Arg Glu Glu  Gln Asp Arg 
    1970                 1975                 1980             


Xaa Pro  Leu Met Phe Gln Arg  Met Glu Pro Pro Ser  Pro Xaa Gln 
    1985                 1990                 1995             


Glu Gly  Gly Pro Gly Gln Asn  Ala Leu Pro Ser Xaa  Gln Leu Asp 
    2000                 2005                 2010             


Pro Gly  Gly Ala Leu Met Ala  His Glu Ser Gly Leu  Lys Glu Ser 
    2015                 2020                 2025             


Pro Ser  Trp Val Xaa Gln Arg  Ala Gln Glu Met Phe  Gln Lys Xaa 
    2030                 2035                 2040             


Gly Xaa  Trp Ser Pro Glu Gln  Gly Pro Pro Xaa Asp  Met Pro Asn 
    2045                 2050                 2055             


Ser Gln  Pro Asn Ser Gln Ser  Val Glu Met Arg Glu  Met Gly Arg 
    2060                 2065                 2070             


Asp Gly  Tyr Ser Asp Ser Glu  His Tyr Leu Pro Met  Glu Gly Gln 
    2075                 2080                 2085             


Gly Arg  Ala Ala Ser Met Pro  Arg Leu Pro Ala Glu  Asn Gln Arg 
    2090                 2095                 2100             


Arg Arg  Gly Arg Pro Arg Gly  Asn Asn Leu Ser Xaa  Ile Ser Asp 
    2105                 2110                 2115             


Xaa Ser  Pro Met Lys Arg Ser  Ala Ser Val Leu Gly  Pro Lys Ala 
    2120                 2125                 2130             


Arg Arg  Leu Asp Asp Tyr Ser  Leu Glu Arg Val Pro  Pro Glu Glu 
    2135                 2140                 2145             


Asn Gln  Arg His His Gln Arg  Arg Arg Asp Arg Ser  His Arg Ala 
    2150                 2155                 2160             


Ser Glu  Arg Ser Leu Gly Arg  Tyr Xaa Asp Val Asp  Xaa Gly Leu 
    2165                 2170                 2175             


Gly Xaa  Asp Leu Ser Met Xaa  Xaa Gln Ser Gly Asp  Leu Pro Ser 
    2180                 2185                 2190             


Lys Glu  Arg Asp Gln Glu Arg  Gly Arg Pro Lys Asp  Arg Lys His 
    2195                 2200                 2205             


Arg Gln  His His His His His  His His His His His  Pro Pro Pro 
    2210                 2215                 2220             


Pro Asp  Lys Asp Arg Tyr Ala  Gln Glu Arg Pro Asp  His Gly Arg 
    2225                 2230                 2235             


Ala Arg  Ala Arg Asp Gln Arg  Trp Ser Arg Ser Pro  Ser Glu Gly 
    2240                 2245                 2250             


Arg Glu  His Met Ala His Arg  Gln Phe Arg Lys Trp  Lys Pro Ser 
    2255                 2260                 2265             


Pro Leu  Asn Ile Trp Tyr Gln  His Ser Ala Ala Gly  Pro Pro Pro 
    2270                 2275                 2280             


Ala Pro  Pro Asp Pro Leu His  Pro Pro Ala Xaa Arg  Val Leu Phe 
    2285                 2290                 2295             


Pro Cys  Asp Pro 
    2300         


<210> 4634
<211> 2495
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1356)..(1356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1452)..(1452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1571)..(1571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1580)..(1580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1637)..(1637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1643)..(1643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1648)..(1648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1677)..(1677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1684)..(1684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1734)..(1734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1741)..(1741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1779)..(1779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1818)..(1818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1890)..(1890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1896)..(1896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1903)..(1903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1938)..(1938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1944)..(1944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1949)..(1949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1952)..(1952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1984)..(1984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1997)..(1997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2010)..(2010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2033)..(2033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2043)..(2043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2045)..(2045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2054)..(2054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2103)..(2103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2107)..(2107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2160)..(2160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2164)..(2164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2168)..(2168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2173)..(2174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2262)..(2262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2265)..(2265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2267)..(2267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2278)..(2278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2281)..(2281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2324)..(2324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2334)..(2334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2345)..(2345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2437)..(2437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2443)..(2443)
<223> Selenocysteine

<400> 4634
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Xaa Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Xaa Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Xaa Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Xaa Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Xaa Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Xaa Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Xaa Gly Ile Leu Ala Xaa Val Gly Xaa Glu Phe Asp Leu Arg 
            180                 185                 190         


Xaa Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Xaa Xaa Cys 
                245                 250                 255     


Phe Glu Glu Gly Xaa Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Xaa Glu Glu Pro Ala Arg Xaa Cys Pro Asn Gly Xaa Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Xaa Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp 
305                 310                 315                 320 


Xaa Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Xaa Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Xaa Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Gly Ala Leu Arg Arg Xaa Xaa Ile Lys Lys Ser Lys Xaa Asp 
            420                 425                 430         


Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser 
        435                 440                 445             


Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu 
    450                 455                 460                 


Asn Ser Xaa Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile 
465                 470                 475                 480 


Arg Arg Met Val Lys Xaa Gln Ala Phe Tyr Trp Xaa Val Leu Ser Leu 
                485                 490                 495     


Val Ala Leu Asn Xaa Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro 
            500                 505                 510         


Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly 
        515                 520                 525             


Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Xaa Arg 
    530                 535                 540                 


Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile 
545                 550                 555                 560 


Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Xaa Ser 
                565                 570                 575     


Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys 
            580                 585                 590         


Val Xaa Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu 
        595                 600                 605             


Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe 
    610                 615                 620                 


Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe 
625                 630                 635                 640 


Asn Phe Asp Glu Gly Xaa Pro Pro Xaa Asn Phe Asp Xaa Phe Pro Ala 
                645                 650                 655     


Ala Ile Met Xaa Val Phe Gln Ile Leu Xaa Gly Glu Asp Trp Asn Glu 
            660                 665                 670         


Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met 
        675                 680                 685             


Val Phe Ser Ile Tyr Phe Ile Val Leu Xaa Leu Phe Gly Asn Tyr Xaa 
    690                 695                 700                 


Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala 
705                 710                 715                 720 


Gln Glu Leu Xaa Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln 
                725                 730                 735     


Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu 
            740                 745                 750         


Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln 
        755                 760                 765             


Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Xaa Ser Glu Met Arg Lys 
    770                 775                 780                 


Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro 
785                 790                 795                 800 


Asp Glu Arg Trp Lys Ala Ala Tyr Xaa Arg His Leu Arg Pro Asp Met 
                805                 810                 815     


Lys Xaa His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg 
            820                 825                 830         


Asn Asn Asn Xaa Asn Lys Ser Arg Ala Ala Glu Pro Xaa Val Asp Gln 
        835                 840                 845             


Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg 
    850                 855                 860                 


Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala 
865                 870                 875                 880 


Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly 
                885                 890                 895     


Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu 
            900                 905                 910         


Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp 
        915                 920                 925             


Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg 
    930                 935                 940                 


Ser Gly Ser Pro Arg Xaa Gly Ala Asp Gly Glu His Arg Arg His Arg 
945                 950                 955                 960 


Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg 
                965                 970                 975     


Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly 
            980                 985                 990         


Glu Gly Glu Gly Pro Asp Gly Gly  Glu Arg Arg Arg Arg  His Arg His 
        995                 1000                 1005             


Gly Ala  Pro Ala Xaa Tyr Glu  Gly Asp Ala Arg Arg  Glu Asp Lys 
    1010                 1015                 1020             


Glu Arg  Arg His Arg Arg Arg  Lys Glu Asn Gln Gly  Ser Gly Val 
    1025                 1030                 1035             


Pro Val  Ser Gly Pro Asn Leu  Ser Xaa Xaa Arg Pro  Ile Gln Gln 
    1040                 1045                 1050             


Asp Leu  Gly Arg Gln Asp Pro  Pro Leu Ala Glu Asp  Ile Asp Asn 
    1055                 1060                 1065             


Met Lys  Asn Asn Lys Leu Ala  Xaa Ala Glu Ser Ala  Ala Pro His 
    1070                 1075                 1080             


Gly Ser  Leu Gly His Ala Gly  Leu Pro Gln Ser Pro  Ala Lys Met 
    1085                 1090                 1095             


Gly Asn  Ser Xaa Asp Pro Gly  Pro Met Leu Ala Ile  Pro Ala Met 
    1100                 1105                 1110             


Ala Xaa  Asn Pro Gln Asn Ala  Ala Ser Arg Arg Xaa  Pro Asn Asn 
    1115                 1120                 1125             


Pro Gly  Asn Pro Ser Asn Pro  Gly Pro Pro Lys Xaa  Pro Glu Asn 
    1130                 1135                 1140             


Ser Leu  Ile Val Xaa Asn Pro  Ser Gly Xaa Gln Xaa  Asn Ser Ala 
    1145                 1150                 1155             


Lys Xaa  Ala Arg Lys Pro Asp  His Xaa Xaa Val Asp  Ile Pro Pro 
    1160                 1165                 1170             


Ala Cys  Pro Pro Pro Leu Asn  His Xaa Val Val Gln  Val Asn Lys 
    1175                 1180                 1185             


Asn Ala  Asn Pro Asp Pro Leu  Pro Lys Lys Glu Glu  Glu Lys Lys 
    1190                 1195                 1200             


Glu Glu  Glu Glu Asp Asp Arg  Gly Glu Asp Gly Pro  Lys Pro Met 
    1205                 1210                 1215             


Pro Pro  Tyr Ser Ser Met Phe  Ile Leu Ser Xaa Xaa  Asn Pro Leu 
    1220                 1225                 1230             


Arg Arg  Leu Cys His Tyr Ile  Leu Asn Leu Arg Tyr  Phe Glu Met 
    1235                 1240                 1245             


Cys Ile  Leu Met Val Ile Ala  Met Ser Ser Ile Ala  Leu Ala Ala 
    1250                 1255                 1260             


Glu Asp  Pro Val Gln Pro Asn  Ala Pro Arg Asn Asn  Val Leu Arg 
    1265                 1270                 1275             


Tyr Phe  Asp Tyr Val Phe Xaa  Gly Val Phe Xaa Phe  Glu Met Val 
    1280                 1285                 1290             


Ile Lys  Met Ile Asp Leu Gly  Leu Val Leu His Gln  Gly Ala Tyr 
    1295                 1300                 1305             


Phe Arg  Asp Leu Trp Asn Ile  Leu Asp Phe Ile Val  Val Ser Gly 
    1310                 1315                 1320             


Ala Leu  Val Ala Phe Ala Phe  Xaa Gly Asn Ser Lys  Gly Lys Asp 
    1325                 1330                 1335             


Ile Asn  Xaa Ile Lys Ser Leu  Arg Val Leu Arg Val  Leu Arg Pro 
    1340                 1345                 1350             


Leu Lys  Xaa Ile Lys Arg Leu  Pro Lys Leu Lys Ala  Val Phe Asp 
    1355                 1360                 1365             


Cys Val  Val Asn Ser Leu Lys  Asn Val Phe Asn Ile  Leu Ile Val 
    1370                 1375                 1380             


Tyr Met  Leu Phe Met Phe Ile  Phe Ala Val Val Ala  Val Gln Leu 
    1385                 1390                 1395             


Phe Lys  Gly Lys Phe Phe His  Cys Xaa Asp Glu Ser  Lys Glu Phe 
    1400                 1405                 1410             


Glu Lys  Asp Cys Arg Gly Lys  Tyr Leu Leu Tyr Glu  Lys Asn Glu 
    1415                 1420                 1425             


Val Lys  Ala Arg Asp Arg Glu  Trp Lys Lys Tyr Glu  Phe His Tyr 
    1430                 1435                 1440             


Asp Asn  Val Leu Trp Ala Leu  Leu Xaa Leu Phe Xaa  Val Ser Xaa 
    1445                 1450                 1455             


Gly Glu  Gly Trp Pro Gln Val  Leu Lys His Ser Val  Asp Ala Xaa 
    1460                 1465                 1470             


Phe Glu  Asn Gln Gly Pro Ser  Pro Gly Tyr Arg Met  Glu Met Ser 
    1475                 1480                 1485             


Ile Phe  Tyr Val Val Tyr Phe  Val Val Phe Pro Phe  Phe Phe Val 
    1490                 1495                 1500             


Asn Ile  Phe Val Ala Leu Ile  Ile Ile Xaa Phe Gln  Glu Gln Gly 
    1505                 1510                 1515             


Asp Lys  Met Met Glu Glu Tyr  Ser Leu Glu Lys Asn  Glu Arg Ala 
    1520                 1525                 1530             


Cys Ile  Asp Phe Ala Ile Ser  Ala Lys Pro Leu Xaa  Arg His Met 
    1535                 1540                 1545             


Pro Gln  Asn Lys Gln Ser Phe  Gln Tyr Arg Met Trp  Gln Phe Val 
    1550                 1555                 1560             


Val Ser  Pro Pro Phe Glu Tyr  Xaa Ile Met Ala Met  Ile Ala Leu 
    1565                 1570                 1575             


Asn Xaa  Ile Val Leu Met Met  Lys Phe Tyr Gly Ala  Ser Val Ala 
    1580                 1585                 1590             


Tyr Glu  Asn Ala Leu Arg Val  Phe Asn Ile Val Phe  Xaa Ser Leu 
    1595                 1600                 1605             


Phe Ser  Leu Glu Cys Val Leu  Lys Val Met Ala Phe  Gly Ile Leu 
    1610                 1615                 1620             


Asn Tyr  Phe Arg Asp Ala Trp  Asn Ile Phe Asp Phe  Val Xaa Val 
    1625                 1630                 1635             


Leu Gly  Ser Ile Xaa Asp Ile  Leu Val Xaa Glu Phe  Gly Asn Asn 
    1640                 1645                 1650             


Phe Ile  Asn Leu Ser Phe Leu  Arg Leu Phe Arg Ala  Ala Arg Leu 
    1655                 1660                 1665             


Ile Lys  Leu Leu Arg Gln Gly  Tyr Xaa Ile Arg Ile  Leu Leu Trp 
    1670                 1675                 1680             


Xaa Phe  Val Gln Ser Phe Lys  Ala Leu Pro Tyr Val  Cys Leu Leu 
    1685                 1690                 1695             


Ile Ala  Met Leu Phe Phe Ile  Tyr Ala Ile Ile Gly  Met Gln Val 
    1700                 1705                 1710             


Phe Gly  Asn Ile Gly Ile Asp  Val Glu Asp Glu Asp  Ser Asp Glu 
    1715                 1720                 1725             


Asp Glu  Phe Gln Ile Xaa Glu  His Asn Asn Phe Arg  Xaa Phe Phe 
    1730                 1735                 1740             


Gln Ala  Leu Met Leu Leu Phe  Arg Ser Ala Xaa Gly  Glu Ala Trp 
    1745                 1750                 1755             


His Asn  Ile Met Leu Ser Cys  Leu Ser Gly Lys Pro  Cys Asp Lys 
    1760                 1765                 1770             


Asn Ser  Gly Ile Leu Xaa Arg  Glu Cys Gly Asn Glu  Phe Ala Tyr 
    1775                 1780                 1785             


Phe Tyr  Phe Val Ser Phe Ile  Phe Leu Cys Ser Phe  Leu Met Leu 
    1790                 1795                 1800             


Asn Leu  Phe Val Ala Val Ile  Met Asp Asn Phe Glu  Tyr Leu Xaa 
    1805                 1810                 1815             


Arg Asp  Ser Ser Ile Leu Gly  Pro His His Leu Asp  Glu Tyr Val 
    1820                 1825                 1830             


Arg Val  Trp Ala Glu Tyr Asp  Pro Ala Ala Trp Gly  Arg Met Pro 
    1835                 1840                 1845             


Tyr Leu  Asp Met Tyr Gln Met  Leu Arg His Met Ser  Pro Pro Leu 
    1850                 1855                 1860             


Gly Leu  Gly Lys Lys Cys Pro  Ala Arg Val Ala Tyr  Lys Arg Leu 
    1865                 1870                 1875             


Leu Arg  Met Asp Leu Pro Val  Ala Asp Asp Asn Xaa  Val His Phe 
    1880                 1885                 1890             


Asn Ser  Xaa Leu Met Ala Leu  Ile Arg Xaa Ala Leu  Asp Ile Lys 
    1895                 1900                 1905             


Ile Ala  Lys Gly Gly Ala Asp  Lys Gln Gln Met Asp  Ala Glu Leu 
    1910                 1915                 1920             


Arg Lys  Glu Met Met Ala Ile  Trp Pro Asn Leu Ser  Gln Lys Xaa 
    1925                 1930                 1935             


Leu Asp  Leu Leu Val Xaa Pro  His Lys Ser Xaa Asp  Leu Xaa Val 
    1940                 1945                 1950             


Gly Lys  Ile Tyr Ala Ala Met  Met Ile Met Glu Tyr  Tyr Arg Gln 
    1955                 1960                 1965             


Ser Lys  Ala Lys Lys Leu Gln  Ala Met Arg Glu Glu  Gln Asp Arg 
    1970                 1975                 1980             


Xaa Pro  Leu Met Phe Gln Arg  Met Glu Pro Pro Ser  Pro Xaa Gln 
    1985                 1990                 1995             


Glu Gly  Gly Pro Gly Gln Asn  Ala Leu Pro Ser Xaa  Gln Leu Asp 
    2000                 2005                 2010             


Pro Gly  Gly Ala Leu Met Ala  His Glu Ser Gly Leu  Lys Glu Ser 
    2015                 2020                 2025             


Pro Ser  Trp Val Xaa Gln Arg  Ala Gln Glu Met Phe  Gln Lys Xaa 
    2030                 2035                 2040             


Gly Xaa  Trp Ser Pro Glu Gln  Gly Pro Pro Xaa Asp  Met Pro Asn 
    2045                 2050                 2055             


Ser Gln  Pro Asn Ser Gln Ser  Val Glu Met Arg Glu  Met Gly Arg 
    2060                 2065                 2070             


Asp Gly  Tyr Ser Asp Ser Glu  His Tyr Leu Pro Met  Glu Gly Gln 
    2075                 2080                 2085             


Gly Arg  Ala Ala Ser Met Pro  Arg Leu Pro Ala Glu  Asn Gln Xaa 
    2090                 2095                 2100             


Ile Ser  Asp Xaa Ser Pro Met  Lys Arg Ser Ala Ser  Val Leu Gly 
    2105                 2110                 2115             


Pro Lys  Ala Arg Arg Leu Asp  Asp Tyr Ser Leu Glu  Arg Val Pro 
    2120                 2125                 2130             


Pro Glu  Glu Asn Gln Arg His  His Gln Arg Arg Arg  Asp Arg Ser 
    2135                 2140                 2145             


His Arg  Ala Ser Glu Arg Ser  Leu Gly Arg Tyr Xaa  Asp Val Asp 
    2150                 2155                 2160             


Xaa Gly  Leu Gly Xaa Asp Leu  Ser Met Xaa Xaa Gln  Ser Gly Asp 
    2165                 2170                 2175             


Leu Pro  Ser Lys Glu Arg Asp  Gln Glu Arg Gly Arg  Pro Lys Asp 
    2180                 2185                 2190             


Arg Lys  His Arg Gln His His  His His His His His  His His His 
    2195                 2200                 2205             


Pro Pro  Pro Pro Asp Lys Asp  Arg Tyr Ala Gln Glu  Arg Pro Asp 
    2210                 2215                 2220             


His Gly  Arg Ala Arg Ala Arg  Asp Gln Arg Trp Ser  Arg Ser Pro 
    2225                 2230                 2235             


Ser Glu  Gly Arg Glu His Met  Ala His Arg Gln Gly  Ser Ser Ser 
    2240                 2245                 2250             


Val Ser  Gly Ser Pro Ala Pro  Ser Xaa Ser Gly Xaa  Ser Xaa Pro 
    2255                 2260                 2265             


Arg Arg  Gly Arg Arg Gln Leu  Pro Gln Xaa Pro Ser  Xaa Pro Arg 
    2270                 2275                 2280             


Pro His  Val Ser Tyr Ser Pro  Val Ile Arg Lys Ala  Gly Gly Ser 
    2285                 2290                 2295             


Gly Pro  Pro Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2300                 2305                 2310             


Gln Ala  Val Ala Arg Pro Gly  Arg Ala Ala Xaa Ser  Gly Pro Arg 
    2315                 2320                 2325             


Arg Tyr  Pro Gly Pro Xaa Ala  Glu Pro Leu Ala Gly  Asp Arg Pro 
    2330                 2335                 2340             


Pro Xaa  Gly Gly His Ser Ser  Gly Arg Ser Pro Arg  Met Glu Arg 
    2345                 2350                 2355             


Arg Val  Pro Gly Pro Ala Arg  Ser Glu Ser Pro Arg  Ala Cys Arg 
    2360                 2365                 2370             


His Gly  Gly Ala Arg Trp Pro  Ala Ser Gly Pro His  Val Ser Glu 
    2375                 2380                 2385             


Gly Pro  Pro Gly Pro Arg His  His Gly Tyr Tyr Arg  Gly Ser Asp 
    2390                 2395                 2400             


Tyr Asp  Glu Ala Asp Gly Pro  Gly Ser Gly Gly Gly  Glu Glu Ala 
    2405                 2410                 2415             


Met Ala  Gly Ala Tyr Asp Ala  Pro Pro Pro Val Arg  His Ala Ser 
    2420                 2425                 2430             


Ser Gly  Ala Xaa Gly Arg Ser  Pro Arg Xaa Pro Arg  Ala Ser Gly 
    2435                 2440                 2445             


Pro Ala  Cys Ala Ser Pro Ser  Arg His Gly Arg Arg  Leu Pro Asn 
    2450                 2455                 2460             


Gly Tyr  Tyr Pro Ala His Gly  Leu Ala Arg Pro Arg  Gly Pro Gly 
    2465                 2470                 2475             


Ser Arg  Lys Gly Leu His Glu  Pro Tyr Ser Glu Ser  Asp Asp Asp 
    2480                 2485                 2490             


Trp Cys  
    2495 


<210> 4635
<211> 2506
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1152)..(1152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1330)..(1330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1340)..(1340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1355)..(1355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1406)..(1406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1451)..(1451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1454)..(1454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1512)..(1512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1544)..(1544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1570)..(1570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1579)..(1579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1605)..(1605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1636)..(1636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1642)..(1642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1647)..(1647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1676)..(1676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1683)..(1683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1733)..(1733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1753)..(1753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1778)..(1778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1817)..(1817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1889)..(1889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1895)..(1895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1902)..(1902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1937)..(1937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1943)..(1943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1948)..(1948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1951)..(1951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1983)..(1983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1996)..(1996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2009)..(2009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2032)..(2032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2042)..(2042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2044)..(2044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2053)..(2053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2114)..(2114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2118)..(2118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2171)..(2171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2175)..(2175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2179)..(2179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2184)..(2185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2273)..(2273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2276)..(2276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2278)..(2278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2289)..(2289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2292)..(2292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2335)..(2335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2345)..(2345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2356)..(2356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2448)..(2448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2454)..(2454)
<223> Selenocysteine

<400> 4635
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Xaa Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Xaa Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Xaa Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Xaa Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Xaa Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Xaa Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Xaa Gly Ile Leu Ala Xaa Val Gly Xaa Glu Phe Asp Leu Arg 
            180                 185                 190         


Xaa Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Xaa Xaa Cys 
                245                 250                 255     


Phe Glu Glu Gly Xaa Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Xaa Glu Glu Pro Ala Arg Xaa Cys Pro Asn Gly Xaa Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Xaa Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp 
305                 310                 315                 320 


Xaa Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Xaa Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Xaa Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Ala Leu Arg Arg Xaa Xaa Ile Lys Lys Ser Lys Xaa Asp Leu 
            420                 425                 430         


Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser Val 
        435                 440                 445             


Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu Asn 
    450                 455                 460                 


Ser Xaa Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile Arg 
465                 470                 475                 480 


Arg Met Val Lys Xaa Gln Ala Phe Tyr Trp Xaa Val Leu Ser Leu Val 
                485                 490                 495     


Ala Leu Asn Xaa Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro Glu 
            500                 505                 510         


Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly Leu 
        515                 520                 525             


Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Xaa Arg Pro 
    530                 535                 540                 


Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile Gly 
545                 550                 555                 560 


Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Xaa Ser Phe 
                565                 570                 575     


Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys Val 
            580                 585                 590         


Xaa Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu Asn 
        595                 600                 605             


Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe Ile 
    610                 615                 620                 


Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe Asn 
625                 630                 635                 640 


Phe Asp Glu Gly Xaa Pro Pro Xaa Asn Phe Asp Xaa Phe Pro Ala Ala 
                645                 650                 655     


Ile Met Xaa Val Phe Gln Ile Leu Xaa Gly Glu Asp Trp Asn Glu Val 
            660                 665                 670         


Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met Val 
        675                 680                 685             


Phe Ser Ile Tyr Phe Ile Val Leu Xaa Leu Phe Gly Asn Tyr Xaa Leu 
    690                 695                 700                 


Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala Gln 
705                 710                 715                 720 


Glu Leu Xaa Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln Lys 
                725                 730                 735     


Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu Ser 
            740                 745                 750         


Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln Lys 
        755                 760                 765             


Pro Ala Lys Ser Val Trp Glu Gln Arg Xaa Ser Glu Met Arg Lys Gln 
    770                 775                 780                 


Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro Asp 
785                 790                 795                 800 


Glu Arg Trp Lys Ala Ala Tyr Xaa Arg His Leu Arg Pro Asp Met Lys 
                805                 810                 815     


Xaa His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg Asn 
            820                 825                 830         


Asn Asn Xaa Asn Lys Ser Arg Ala Ala Glu Pro Xaa Val Asp Gln Arg 
        835                 840                 845             


Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg Tyr 
    850                 855                 860                 


His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala Arg 
865                 870                 875                 880 


Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly Pro 
                885                 890                 895     


Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu Gln 
            900                 905                 910         


Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp Pro 
        915                 920                 925             


His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg Ser 
    930                 935                 940                 


Gly Ser Pro Arg Xaa Gly Ala Asp Gly Glu His Arg Arg His Arg Ala 
945                 950                 955                 960 


His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg Arg 
                965                 970                 975     


Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly Glu 
            980                 985                 990         


Gly Glu Gly Pro Asp Gly Gly Glu  Arg Arg Arg Arg His  Arg His Gly 
        995                 1000                 1005             


Ala Pro  Ala Xaa Tyr Glu Gly  Asp Ala Arg Arg Glu  Asp Lys Glu 
    1010                 1015                 1020             


Arg Arg  His Arg Arg Arg Lys  Glu Asn Gln Gly Ser  Gly Val Pro 
    1025                 1030                 1035             


Val Ser  Gly Pro Asn Leu Ser  Xaa Xaa Arg Pro Ile  Gln Gln Asp 
    1040                 1045                 1050             


Leu Gly  Arg Gln Asp Pro Pro  Leu Ala Glu Asp Ile  Asp Asn Met 
    1055                 1060                 1065             


Lys Asn  Asn Lys Leu Ala Xaa  Ala Glu Ser Ala Ala  Pro His Gly 
    1070                 1075                 1080             


Ser Leu  Gly His Ala Gly Leu  Pro Gln Ser Pro Ala  Lys Met Gly 
    1085                 1090                 1095             


Asn Ser  Xaa Asp Pro Gly Pro  Met Leu Ala Ile Pro  Ala Met Ala 
    1100                 1105                 1110             


Xaa Asn  Pro Gln Asn Ala Ala  Ser Arg Arg Xaa Pro  Asn Asn Pro 
    1115                 1120                 1125             


Gly Asn  Pro Ser Asn Pro Gly  Pro Pro Lys Xaa Pro  Glu Asn Ser 
    1130                 1135                 1140             


Leu Ile  Val Xaa Asn Pro Ser  Gly Xaa Gln Xaa Asn  Ser Ala Lys 
    1145                 1150                 1155             


Xaa Ala  Arg Lys Pro Asp His  Xaa Xaa Val Asp Ile  Pro Pro Ala 
    1160                 1165                 1170             


Cys Pro  Pro Pro Leu Asn His  Xaa Val Val Gln Val  Asn Lys Asn 
    1175                 1180                 1185             


Ala Asn  Pro Asp Pro Leu Pro  Lys Lys Glu Glu Glu  Lys Lys Glu 
    1190                 1195                 1200             


Glu Glu  Glu Asp Asp Arg Gly  Glu Asp Gly Pro Lys  Pro Met Pro 
    1205                 1210                 1215             


Pro Tyr  Ser Ser Met Phe Ile  Leu Ser Xaa Xaa Asn  Pro Leu Arg 
    1220                 1225                 1230             


Arg Leu  Cys His Tyr Ile Leu  Asn Leu Arg Tyr Phe  Glu Met Cys 
    1235                 1240                 1245             


Ile Leu  Met Val Ile Ala Met  Ser Ser Ile Ala Leu  Ala Ala Glu 
    1250                 1255                 1260             


Asp Pro  Val Gln Pro Asn Ala  Pro Arg Asn Asn Val  Leu Arg Tyr 
    1265                 1270                 1275             


Phe Asp  Tyr Val Phe Xaa Gly  Val Phe Xaa Phe Glu  Met Val Ile 
    1280                 1285                 1290             


Lys Met  Ile Asp Leu Gly Leu  Val Leu His Gln Gly  Ala Tyr Phe 
    1295                 1300                 1305             


Arg Asp  Leu Trp Asn Ile Leu  Asp Phe Ile Val Val  Ser Gly Ala 
    1310                 1315                 1320             


Leu Val  Ala Phe Ala Phe Xaa  Gly Asn Ser Lys Gly  Lys Asp Ile 
    1325                 1330                 1335             


Asn Xaa  Ile Lys Ser Leu Arg  Val Leu Arg Val Leu  Arg Pro Leu 
    1340                 1345                 1350             


Lys Xaa  Ile Lys Arg Leu Pro  Lys Leu Lys Ala Val  Phe Asp Cys 
    1355                 1360                 1365             


Val Val  Asn Ser Leu Lys Asn  Val Phe Asn Ile Leu  Ile Val Tyr 
    1370                 1375                 1380             


Met Leu  Phe Met Phe Ile Phe  Ala Val Val Ala Val  Gln Leu Phe 
    1385                 1390                 1395             


Lys Gly  Lys Phe Phe His Cys  Xaa Asp Glu Ser Lys  Glu Phe Glu 
    1400                 1405                 1410             


Lys Asp  Cys Arg Gly Lys Tyr  Leu Leu Tyr Glu Lys  Asn Glu Val 
    1415                 1420                 1425             


Lys Ala  Arg Asp Arg Glu Trp  Lys Lys Tyr Glu Phe  His Tyr Asp 
    1430                 1435                 1440             


Asn Val  Leu Trp Ala Leu Leu  Xaa Leu Phe Xaa Val  Ser Xaa Gly 
    1445                 1450                 1455             


Glu Gly  Trp Pro Gln Val Leu  Lys His Ser Val Asp  Ala Xaa Phe 
    1460                 1465                 1470             


Glu Asn  Gln Gly Pro Ser Pro  Gly Tyr Arg Met Glu  Met Ser Ile 
    1475                 1480                 1485             


Phe Tyr  Val Val Tyr Phe Val  Val Phe Pro Phe Phe  Phe Val Asn 
    1490                 1495                 1500             


Ile Phe  Val Ala Leu Ile Ile  Ile Xaa Phe Gln Glu  Gln Gly Asp 
    1505                 1510                 1515             


Lys Met  Met Glu Glu Tyr Ser  Leu Glu Lys Asn Glu  Arg Ala Cys 
    1520                 1525                 1530             


Ile Asp  Phe Ala Ile Ser Ala  Lys Pro Leu Xaa Arg  His Met Pro 
    1535                 1540                 1545             


Gln Asn  Lys Gln Ser Phe Gln  Tyr Arg Met Trp Gln  Phe Val Val 
    1550                 1555                 1560             


Ser Pro  Pro Phe Glu Tyr Xaa  Ile Met Ala Met Ile  Ala Leu Asn 
    1565                 1570                 1575             


Xaa Ile  Val Leu Met Met Lys  Phe Tyr Gly Ala Ser  Val Ala Tyr 
    1580                 1585                 1590             


Glu Asn  Ala Leu Arg Val Phe  Asn Ile Val Phe Xaa  Ser Leu Phe 
    1595                 1600                 1605             


Ser Leu  Glu Cys Val Leu Lys  Val Met Ala Phe Gly  Ile Leu Asn 
    1610                 1615                 1620             


Tyr Phe  Arg Asp Ala Trp Asn  Ile Phe Asp Phe Val  Xaa Val Leu 
    1625                 1630                 1635             


Gly Ser  Ile Xaa Asp Ile Leu  Val Xaa Glu Phe Gly  Asn Asn Phe 
    1640                 1645                 1650             


Ile Asn  Leu Ser Phe Leu Arg  Leu Phe Arg Ala Ala  Arg Leu Ile 
    1655                 1660                 1665             


Lys Leu  Leu Arg Gln Gly Tyr  Xaa Ile Arg Ile Leu  Leu Trp Xaa 
    1670                 1675                 1680             


Phe Val  Gln Ser Phe Lys Ala  Leu Pro Tyr Val Cys  Leu Leu Ile 
    1685                 1690                 1695             


Ala Met  Leu Phe Phe Ile Tyr  Ala Ile Ile Gly Met  Gln Val Phe 
    1700                 1705                 1710             


Gly Asn  Ile Gly Ile Asp Val  Glu Asp Glu Asp Ser  Asp Glu Asp 
    1715                 1720                 1725             


Glu Phe  Gln Ile Xaa Glu His  Asn Asn Phe Arg Xaa  Phe Phe Gln 
    1730                 1735                 1740             


Ala Leu  Met Leu Leu Phe Arg  Ser Ala Xaa Gly Glu  Ala Trp His 
    1745                 1750                 1755             


Asn Ile  Met Leu Ser Cys Leu  Ser Gly Lys Pro Cys  Asp Lys Asn 
    1760                 1765                 1770             


Ser Gly  Ile Leu Xaa Arg Glu  Cys Gly Asn Glu Phe  Ala Tyr Phe 
    1775                 1780                 1785             


Tyr Phe  Val Ser Phe Ile Phe  Leu Cys Ser Phe Leu  Met Leu Asn 
    1790                 1795                 1800             


Leu Phe  Val Ala Val Ile Met  Asp Asn Phe Glu Tyr  Leu Xaa Arg 
    1805                 1810                 1815             


Asp Ser  Ser Ile Leu Gly Pro  His His Leu Asp Glu  Tyr Val Arg 
    1820                 1825                 1830             


Val Trp  Ala Glu Tyr Asp Pro  Ala Ala Trp Gly Arg  Met Pro Tyr 
    1835                 1840                 1845             


Leu Asp  Met Tyr Gln Met Leu  Arg His Met Ser Pro  Pro Leu Gly 
    1850                 1855                 1860             


Leu Gly  Lys Lys Cys Pro Ala  Arg Val Ala Tyr Lys  Arg Leu Leu 
    1865                 1870                 1875             


Arg Met  Asp Leu Pro Val Ala  Asp Asp Asn Xaa Val  His Phe Asn 
    1880                 1885                 1890             


Ser Xaa  Leu Met Ala Leu Ile  Arg Xaa Ala Leu Asp  Ile Lys Ile 
    1895                 1900                 1905             


Ala Lys  Gly Gly Ala Asp Lys  Gln Gln Met Asp Ala  Glu Leu Arg 
    1910                 1915                 1920             


Lys Glu  Met Met Ala Ile Trp  Pro Asn Leu Ser Gln  Lys Xaa Leu 
    1925                 1930                 1935             


Asp Leu  Leu Val Xaa Pro His  Lys Ser Xaa Asp Leu  Xaa Val Gly 
    1940                 1945                 1950             


Lys Ile  Tyr Ala Ala Met Met  Ile Met Glu Tyr Tyr  Arg Gln Ser 
    1955                 1960                 1965             


Lys Ala  Lys Lys Leu Gln Ala  Met Arg Glu Glu Gln  Asp Arg Xaa 
    1970                 1975                 1980             


Pro Leu  Met Phe Gln Arg Met  Glu Pro Pro Ser Pro  Xaa Gln Glu 
    1985                 1990                 1995             


Gly Gly  Pro Gly Gln Asn Ala  Leu Pro Ser Xaa Gln  Leu Asp Pro 
    2000                 2005                 2010             


Gly Gly  Ala Leu Met Ala His  Glu Ser Gly Leu Lys  Glu Ser Pro 
    2015                 2020                 2025             


Ser Trp  Val Xaa Gln Arg Ala  Gln Glu Met Phe Gln  Lys Xaa Gly 
    2030                 2035                 2040             


Xaa Trp  Ser Pro Glu Gln Gly  Pro Pro Xaa Asp Met  Pro Asn Ser 
    2045                 2050                 2055             


Gln Pro  Asn Ser Gln Ser Val  Glu Met Arg Glu Met  Gly Arg Asp 
    2060                 2065                 2070             


Gly Tyr  Ser Asp Ser Glu His  Tyr Leu Pro Met Glu  Gly Gln Gly 
    2075                 2080                 2085             


Arg Ala  Ala Ser Met Pro Arg  Leu Pro Ala Glu Asn  Gln Arg Arg 
    2090                 2095                 2100             


Arg Gly  Arg Pro Arg Gly Asn  Asn Leu Ser Xaa Ile  Ser Asp Xaa 
    2105                 2110                 2115             


Ser Pro  Met Lys Arg Ser Ala  Ser Val Leu Gly Pro  Lys Ala Arg 
    2120                 2125                 2130             


Arg Leu  Asp Asp Tyr Ser Leu  Glu Arg Val Pro Pro  Glu Glu Asn 
    2135                 2140                 2145             


Gln Arg  His His Gln Arg Arg  Arg Asp Arg Ser His  Arg Ala Ser 
    2150                 2155                 2160             


Glu Arg  Ser Leu Gly Arg Tyr  Xaa Asp Val Asp Xaa  Gly Leu Gly 
    2165                 2170                 2175             


Xaa Asp  Leu Ser Met Xaa Xaa  Gln Ser Gly Asp Leu  Pro Ser Lys 
    2180                 2185                 2190             


Glu Arg  Asp Gln Glu Arg Gly  Arg Pro Lys Asp Arg  Lys His Arg 
    2195                 2200                 2205             


Gln His  His His His His His  His His His His Pro  Pro Pro Pro 
    2210                 2215                 2220             


Asp Lys  Asp Arg Tyr Ala Gln  Glu Arg Pro Asp His  Gly Arg Ala 
    2225                 2230                 2235             


Arg Ala  Arg Asp Gln Arg Trp  Ser Arg Ser Pro Ser  Glu Gly Arg 
    2240                 2245                 2250             


Glu His  Met Ala His Arg Gln  Gly Ser Ser Ser Val  Ser Gly Ser 
    2255                 2260                 2265             


Pro Ala  Pro Ser Xaa Ser Gly  Xaa Ser Xaa Pro Arg  Arg Gly Arg 
    2270                 2275                 2280             


Arg Gln  Leu Pro Gln Xaa Pro  Ser Xaa Pro Arg Pro  His Val Ser 
    2285                 2290                 2295             


Tyr Ser  Pro Val Ile Arg Lys  Ala Gly Gly Ser Gly  Pro Pro Gln 
    2300                 2305                 2310             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Ala Val Ala 
    2315                 2320                 2325             


Arg Pro  Gly Arg Ala Ala Xaa  Ser Gly Pro Arg Arg  Tyr Pro Gly 
    2330                 2335                 2340             


Pro Xaa  Ala Glu Pro Leu Ala  Gly Asp Arg Pro Pro  Xaa Gly Gly 
    2345                 2350                 2355             


His Ser  Ser Gly Arg Ser Pro  Arg Met Glu Arg Arg  Val Pro Gly 
    2360                 2365                 2370             


Pro Ala  Arg Ser Glu Ser Pro  Arg Ala Cys Arg His  Gly Gly Ala 
    2375                 2380                 2385             


Arg Trp  Pro Ala Ser Gly Pro  His Val Ser Glu Gly  Pro Pro Gly 
    2390                 2395                 2400             


Pro Arg  His His Gly Tyr Tyr  Arg Gly Ser Asp Tyr  Asp Glu Ala 
    2405                 2410                 2415             


Asp Gly  Pro Gly Ser Gly Gly  Gly Glu Glu Ala Met  Ala Gly Ala 
    2420                 2425                 2430             


Tyr Asp  Ala Pro Pro Pro Val  Arg His Ala Ser Ser  Gly Ala Xaa 
    2435                 2440                 2445             


Gly Arg  Ser Pro Arg Xaa Pro  Arg Ala Ser Gly Pro  Ala Cys Ala 
    2450                 2455                 2460             


Ser Pro  Ser Arg His Gly Arg  Arg Leu Pro Asn Gly  Tyr Tyr Pro 
    2465                 2470                 2475             


Ala His  Gly Leu Ala Arg Pro  Arg Gly Pro Gly Ser  Arg Lys Gly 
    2480                 2485                 2490             


Leu His  Glu Pro Tyr Ser Glu  Ser Asp Asp Asp Trp  Cys 
    2495                 2500                 2505     


<210> 4636
<211> 2507
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1356)..(1356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1452)..(1452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1571)..(1571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1580)..(1580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1637)..(1637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1643)..(1643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1648)..(1648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1677)..(1677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1684)..(1684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1734)..(1734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1741)..(1741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1779)..(1779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1818)..(1818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1890)..(1890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1896)..(1896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1903)..(1903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1938)..(1938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1944)..(1944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1949)..(1949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1952)..(1952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1984)..(1984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1997)..(1997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2010)..(2010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2033)..(2033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2043)..(2043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2045)..(2045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2054)..(2054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2115)..(2115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2119)..(2119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2172)..(2172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2176)..(2176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2180)..(2180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2185)..(2186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2274)..(2274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2277)..(2277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2279)..(2279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2290)..(2290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2293)..(2293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2336)..(2336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2346)..(2346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2357)..(2357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2449)..(2449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2455)..(2455)
<223> Selenocysteine

<400> 4636
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Xaa Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Xaa Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Xaa Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Xaa Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Xaa Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Xaa Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Xaa Gly Ile Leu Ala Xaa Val Gly Xaa Glu Phe Asp Leu Arg 
            180                 185                 190         


Xaa Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Xaa Xaa Cys 
                245                 250                 255     


Phe Glu Glu Gly Xaa Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Xaa Glu Glu Pro Ala Arg Xaa Cys Pro Asn Gly Xaa Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Xaa Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp 
305                 310                 315                 320 


Xaa Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Xaa Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Xaa Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Gly Ala Leu Arg Arg Xaa Xaa Ile Lys Lys Ser Lys Xaa Asp 
            420                 425                 430         


Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser 
        435                 440                 445             


Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu 
    450                 455                 460                 


Asn Ser Xaa Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile 
465                 470                 475                 480 


Arg Arg Met Val Lys Xaa Gln Ala Phe Tyr Trp Xaa Val Leu Ser Leu 
                485                 490                 495     


Val Ala Leu Asn Xaa Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro 
            500                 505                 510         


Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly 
        515                 520                 525             


Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Xaa Arg 
    530                 535                 540                 


Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile 
545                 550                 555                 560 


Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Xaa Ser 
                565                 570                 575     


Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys 
            580                 585                 590         


Val Xaa Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu 
        595                 600                 605             


Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe 
    610                 615                 620                 


Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe 
625                 630                 635                 640 


Asn Phe Asp Glu Gly Xaa Pro Pro Xaa Asn Phe Asp Xaa Phe Pro Ala 
                645                 650                 655     


Ala Ile Met Xaa Val Phe Gln Ile Leu Xaa Gly Glu Asp Trp Asn Glu 
            660                 665                 670         


Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met 
        675                 680                 685             


Val Phe Ser Ile Tyr Phe Ile Val Leu Xaa Leu Phe Gly Asn Tyr Xaa 
    690                 695                 700                 


Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala 
705                 710                 715                 720 


Gln Glu Leu Xaa Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln 
                725                 730                 735     


Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu 
            740                 745                 750         


Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln 
        755                 760                 765             


Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Xaa Ser Glu Met Arg Lys 
    770                 775                 780                 


Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro 
785                 790                 795                 800 


Asp Glu Arg Trp Lys Ala Ala Tyr Xaa Arg His Leu Arg Pro Asp Met 
                805                 810                 815     


Lys Xaa His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg 
            820                 825                 830         


Asn Asn Asn Xaa Asn Lys Ser Arg Ala Ala Glu Pro Xaa Val Asp Gln 
        835                 840                 845             


Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg 
    850                 855                 860                 


Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala 
865                 870                 875                 880 


Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly 
                885                 890                 895     


Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu 
            900                 905                 910         


Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp 
        915                 920                 925             


Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg 
    930                 935                 940                 


Ser Gly Ser Pro Arg Xaa Gly Ala Asp Gly Glu His Arg Arg His Arg 
945                 950                 955                 960 


Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg 
                965                 970                 975     


Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly 
            980                 985                 990         


Glu Gly Glu Gly Pro Asp Gly Gly  Glu Arg Arg Arg Arg  His Arg His 
        995                 1000                 1005             


Gly Ala  Pro Ala Xaa Tyr Glu  Gly Asp Ala Arg Arg  Glu Asp Lys 
    1010                 1015                 1020             


Glu Arg  Arg His Arg Arg Arg  Lys Glu Asn Gln Gly  Ser Gly Val 
    1025                 1030                 1035             


Pro Val  Ser Gly Pro Asn Leu  Ser Xaa Xaa Arg Pro  Ile Gln Gln 
    1040                 1045                 1050             


Asp Leu  Gly Arg Gln Asp Pro  Pro Leu Ala Glu Asp  Ile Asp Asn 
    1055                 1060                 1065             


Met Lys  Asn Asn Lys Leu Ala  Xaa Ala Glu Ser Ala  Ala Pro His 
    1070                 1075                 1080             


Gly Ser  Leu Gly His Ala Gly  Leu Pro Gln Ser Pro  Ala Lys Met 
    1085                 1090                 1095             


Gly Asn  Ser Xaa Asp Pro Gly  Pro Met Leu Ala Ile  Pro Ala Met 
    1100                 1105                 1110             


Ala Xaa  Asn Pro Gln Asn Ala  Ala Ser Arg Arg Xaa  Pro Asn Asn 
    1115                 1120                 1125             


Pro Gly  Asn Pro Ser Asn Pro  Gly Pro Pro Lys Xaa  Pro Glu Asn 
    1130                 1135                 1140             


Ser Leu  Ile Val Xaa Asn Pro  Ser Gly Xaa Gln Xaa  Asn Ser Ala 
    1145                 1150                 1155             


Lys Xaa  Ala Arg Lys Pro Asp  His Xaa Xaa Val Asp  Ile Pro Pro 
    1160                 1165                 1170             


Ala Cys  Pro Pro Pro Leu Asn  His Xaa Val Val Gln  Val Asn Lys 
    1175                 1180                 1185             


Asn Ala  Asn Pro Asp Pro Leu  Pro Lys Lys Glu Glu  Glu Lys Lys 
    1190                 1195                 1200             


Glu Glu  Glu Glu Asp Asp Arg  Gly Glu Asp Gly Pro  Lys Pro Met 
    1205                 1210                 1215             


Pro Pro  Tyr Ser Ser Met Phe  Ile Leu Ser Xaa Xaa  Asn Pro Leu 
    1220                 1225                 1230             


Arg Arg  Leu Cys His Tyr Ile  Leu Asn Leu Arg Tyr  Phe Glu Met 
    1235                 1240                 1245             


Cys Ile  Leu Met Val Ile Ala  Met Ser Ser Ile Ala  Leu Ala Ala 
    1250                 1255                 1260             


Glu Asp  Pro Val Gln Pro Asn  Ala Pro Arg Asn Asn  Val Leu Arg 
    1265                 1270                 1275             


Tyr Phe  Asp Tyr Val Phe Xaa  Gly Val Phe Xaa Phe  Glu Met Val 
    1280                 1285                 1290             


Ile Lys  Met Ile Asp Leu Gly  Leu Val Leu His Gln  Gly Ala Tyr 
    1295                 1300                 1305             


Phe Arg  Asp Leu Trp Asn Ile  Leu Asp Phe Ile Val  Val Ser Gly 
    1310                 1315                 1320             


Ala Leu  Val Ala Phe Ala Phe  Xaa Gly Asn Ser Lys  Gly Lys Asp 
    1325                 1330                 1335             


Ile Asn  Xaa Ile Lys Ser Leu  Arg Val Leu Arg Val  Leu Arg Pro 
    1340                 1345                 1350             


Leu Lys  Xaa Ile Lys Arg Leu  Pro Lys Leu Lys Ala  Val Phe Asp 
    1355                 1360                 1365             


Cys Val  Val Asn Ser Leu Lys  Asn Val Phe Asn Ile  Leu Ile Val 
    1370                 1375                 1380             


Tyr Met  Leu Phe Met Phe Ile  Phe Ala Val Val Ala  Val Gln Leu 
    1385                 1390                 1395             


Phe Lys  Gly Lys Phe Phe His  Cys Xaa Asp Glu Ser  Lys Glu Phe 
    1400                 1405                 1410             


Glu Lys  Asp Cys Arg Gly Lys  Tyr Leu Leu Tyr Glu  Lys Asn Glu 
    1415                 1420                 1425             


Val Lys  Ala Arg Asp Arg Glu  Trp Lys Lys Tyr Glu  Phe His Tyr 
    1430                 1435                 1440             


Asp Asn  Val Leu Trp Ala Leu  Leu Xaa Leu Phe Xaa  Val Ser Xaa 
    1445                 1450                 1455             


Gly Glu  Gly Trp Pro Gln Val  Leu Lys His Ser Val  Asp Ala Xaa 
    1460                 1465                 1470             


Phe Glu  Asn Gln Gly Pro Ser  Pro Gly Tyr Arg Met  Glu Met Ser 
    1475                 1480                 1485             


Ile Phe  Tyr Val Val Tyr Phe  Val Val Phe Pro Phe  Phe Phe Val 
    1490                 1495                 1500             


Asn Ile  Phe Val Ala Leu Ile  Ile Ile Xaa Phe Gln  Glu Gln Gly 
    1505                 1510                 1515             


Asp Lys  Met Met Glu Glu Tyr  Ser Leu Glu Lys Asn  Glu Arg Ala 
    1520                 1525                 1530             


Cys Ile  Asp Phe Ala Ile Ser  Ala Lys Pro Leu Xaa  Arg His Met 
    1535                 1540                 1545             


Pro Gln  Asn Lys Gln Ser Phe  Gln Tyr Arg Met Trp  Gln Phe Val 
    1550                 1555                 1560             


Val Ser  Pro Pro Phe Glu Tyr  Xaa Ile Met Ala Met  Ile Ala Leu 
    1565                 1570                 1575             


Asn Xaa  Ile Val Leu Met Met  Lys Phe Tyr Gly Ala  Ser Val Ala 
    1580                 1585                 1590             


Tyr Glu  Asn Ala Leu Arg Val  Phe Asn Ile Val Phe  Xaa Ser Leu 
    1595                 1600                 1605             


Phe Ser  Leu Glu Cys Val Leu  Lys Val Met Ala Phe  Gly Ile Leu 
    1610                 1615                 1620             


Asn Tyr  Phe Arg Asp Ala Trp  Asn Ile Phe Asp Phe  Val Xaa Val 
    1625                 1630                 1635             


Leu Gly  Ser Ile Xaa Asp Ile  Leu Val Xaa Glu Phe  Gly Asn Asn 
    1640                 1645                 1650             


Phe Ile  Asn Leu Ser Phe Leu  Arg Leu Phe Arg Ala  Ala Arg Leu 
    1655                 1660                 1665             


Ile Lys  Leu Leu Arg Gln Gly  Tyr Xaa Ile Arg Ile  Leu Leu Trp 
    1670                 1675                 1680             


Xaa Phe  Val Gln Ser Phe Lys  Ala Leu Pro Tyr Val  Cys Leu Leu 
    1685                 1690                 1695             


Ile Ala  Met Leu Phe Phe Ile  Tyr Ala Ile Ile Gly  Met Gln Val 
    1700                 1705                 1710             


Phe Gly  Asn Ile Gly Ile Asp  Val Glu Asp Glu Asp  Ser Asp Glu 
    1715                 1720                 1725             


Asp Glu  Phe Gln Ile Xaa Glu  His Asn Asn Phe Arg  Xaa Phe Phe 
    1730                 1735                 1740             


Gln Ala  Leu Met Leu Leu Phe  Arg Ser Ala Xaa Gly  Glu Ala Trp 
    1745                 1750                 1755             


His Asn  Ile Met Leu Ser Cys  Leu Ser Gly Lys Pro  Cys Asp Lys 
    1760                 1765                 1770             


Asn Ser  Gly Ile Leu Xaa Arg  Glu Cys Gly Asn Glu  Phe Ala Tyr 
    1775                 1780                 1785             


Phe Tyr  Phe Val Ser Phe Ile  Phe Leu Cys Ser Phe  Leu Met Leu 
    1790                 1795                 1800             


Asn Leu  Phe Val Ala Val Ile  Met Asp Asn Phe Glu  Tyr Leu Xaa 
    1805                 1810                 1815             


Arg Asp  Ser Ser Ile Leu Gly  Pro His His Leu Asp  Glu Tyr Val 
    1820                 1825                 1830             


Arg Val  Trp Ala Glu Tyr Asp  Pro Ala Ala Cys Gly  Arg Ile His 
    1835                 1840                 1845             


Tyr Lys  Asp Met Tyr Ser Leu  Leu Arg Val Ile Ser  Pro Pro Leu 
    1850                 1855                 1860             


Gly Leu  Gly Lys Lys Cys Pro  His Arg Val Ala Cys  Lys Arg Leu 
    1865                 1870                 1875             


Leu Arg  Met Asp Leu Pro Val  Ala Asp Asp Asn Xaa  Val His Phe 
    1880                 1885                 1890             


Asn Ser  Xaa Leu Met Ala Leu  Ile Arg Xaa Ala Leu  Asp Ile Lys 
    1895                 1900                 1905             


Ile Ala  Lys Gly Gly Ala Asp  Lys Gln Gln Met Asp  Ala Glu Leu 
    1910                 1915                 1920             


Arg Lys  Glu Met Met Ala Ile  Trp Pro Asn Leu Ser  Gln Lys Xaa 
    1925                 1930                 1935             


Leu Asp  Leu Leu Val Xaa Pro  His Lys Ser Xaa Asp  Leu Xaa Val 
    1940                 1945                 1950             


Gly Lys  Ile Tyr Ala Ala Met  Met Ile Met Glu Tyr  Tyr Arg Gln 
    1955                 1960                 1965             


Ser Lys  Ala Lys Lys Leu Gln  Ala Met Arg Glu Glu  Gln Asp Arg 
    1970                 1975                 1980             


Xaa Pro  Leu Met Phe Gln Arg  Met Glu Pro Pro Ser  Pro Xaa Gln 
    1985                 1990                 1995             


Glu Gly  Gly Pro Gly Gln Asn  Ala Leu Pro Ser Xaa  Gln Leu Asp 
    2000                 2005                 2010             


Pro Gly  Gly Ala Leu Met Ala  His Glu Ser Gly Leu  Lys Glu Ser 
    2015                 2020                 2025             


Pro Ser  Trp Val Xaa Gln Arg  Ala Gln Glu Met Phe  Gln Lys Xaa 
    2030                 2035                 2040             


Gly Xaa  Trp Ser Pro Glu Gln  Gly Pro Pro Xaa Asp  Met Pro Asn 
    2045                 2050                 2055             


Ser Gln  Pro Asn Ser Gln Ser  Val Glu Met Arg Glu  Met Gly Arg 
    2060                 2065                 2070             


Asp Gly  Tyr Ser Asp Ser Glu  His Tyr Leu Pro Met  Glu Gly Gln 
    2075                 2080                 2085             


Gly Arg  Ala Ala Ser Met Pro  Arg Leu Pro Ala Glu  Asn Gln Arg 
    2090                 2095                 2100             


Arg Arg  Gly Arg Pro Arg Gly  Asn Asn Leu Ser Xaa  Ile Ser Asp 
    2105                 2110                 2115             


Xaa Ser  Pro Met Lys Arg Ser  Ala Ser Val Leu Gly  Pro Lys Ala 
    2120                 2125                 2130             


Arg Arg  Leu Asp Asp Tyr Ser  Leu Glu Arg Val Pro  Pro Glu Glu 
    2135                 2140                 2145             


Asn Gln  Arg His His Gln Arg  Arg Arg Asp Arg Ser  His Arg Ala 
    2150                 2155                 2160             


Ser Glu  Arg Ser Leu Gly Arg  Tyr Xaa Asp Val Asp  Xaa Gly Leu 
    2165                 2170                 2175             


Gly Xaa  Asp Leu Ser Met Xaa  Xaa Gln Ser Gly Asp  Leu Pro Ser 
    2180                 2185                 2190             


Lys Glu  Arg Asp Gln Glu Arg  Gly Arg Pro Lys Asp  Arg Lys His 
    2195                 2200                 2205             


Arg Gln  His His His His His  His His His His His  Pro Pro Pro 
    2210                 2215                 2220             


Pro Asp  Lys Asp Arg Tyr Ala  Gln Glu Arg Pro Asp  His Gly Arg 
    2225                 2230                 2235             


Ala Arg  Ala Arg Asp Gln Arg  Trp Ser Arg Ser Pro  Ser Glu Gly 
    2240                 2245                 2250             


Arg Glu  His Met Ala His Arg  Gln Gly Ser Ser Ser  Val Ser Gly 
    2255                 2260                 2265             


Ser Pro  Ala Pro Ser Xaa Ser  Gly Xaa Ser Xaa Pro  Arg Arg Gly 
    2270                 2275                 2280             


Arg Arg  Gln Leu Pro Gln Xaa  Pro Ser Xaa Pro Arg  Pro His Val 
    2285                 2290                 2295             


Ser Tyr  Ser Pro Val Ile Arg  Lys Ala Gly Gly Ser  Gly Pro Pro 
    2300                 2305                 2310             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Ala Val 
    2315                 2320                 2325             


Ala Arg  Pro Gly Arg Ala Ala  Xaa Ser Gly Pro Arg  Arg Tyr Pro 
    2330                 2335                 2340             


Gly Pro  Xaa Ala Glu Pro Leu  Ala Gly Asp Arg Pro  Pro Xaa Gly 
    2345                 2350                 2355             


Gly His  Ser Ser Gly Arg Ser  Pro Arg Met Glu Arg  Arg Val Pro 
    2360                 2365                 2370             


Gly Pro  Ala Arg Ser Glu Ser  Pro Arg Ala Cys Arg  His Gly Gly 
    2375                 2380                 2385             


Ala Arg  Trp Pro Ala Ser Gly  Pro His Val Ser Glu  Gly Pro Pro 
    2390                 2395                 2400             


Gly Pro  Arg His His Gly Tyr  Tyr Arg Gly Ser Asp  Tyr Asp Glu 
    2405                 2410                 2415             


Ala Asp  Gly Pro Gly Ser Gly  Gly Gly Glu Glu Ala  Met Ala Gly 
    2420                 2425                 2430             


Ala Tyr  Asp Ala Pro Pro Pro  Val Arg His Ala Ser  Ser Gly Ala 
    2435                 2440                 2445             


Xaa Gly  Arg Ser Pro Arg Xaa  Pro Arg Ala Ser Gly  Pro Ala Cys 
    2450                 2455                 2460             


Ala Ser  Pro Ser Arg His Gly  Arg Arg Leu Pro Asn  Gly Tyr Tyr 
    2465                 2470                 2475             


Pro Ala  His Gly Leu Ala Arg  Pro Arg Gly Pro Gly  Ser Arg Lys 
    2480                 2485                 2490             


Gly Leu  His Glu Pro Tyr Ser  Glu Ser Asp Asp Asp  Trp Cys 
    2495                 2500                 2505         


<210> 4637
<211> 2507
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1356)..(1356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1452)..(1452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1571)..(1571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1580)..(1580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1637)..(1637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1643)..(1643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1648)..(1648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1677)..(1677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1684)..(1684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1734)..(1734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1741)..(1741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1779)..(1779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1818)..(1818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1890)..(1890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1896)..(1896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1903)..(1903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1938)..(1938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1944)..(1944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1949)..(1949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1952)..(1952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1984)..(1984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1997)..(1997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2010)..(2010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2033)..(2033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2043)..(2043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2045)..(2045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2054)..(2054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2115)..(2115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2119)..(2119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2172)..(2172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2176)..(2176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2180)..(2180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2185)..(2186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2274)..(2274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2277)..(2277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2279)..(2279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2290)..(2290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2293)..(2293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2336)..(2336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2346)..(2346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2357)..(2357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2449)..(2449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2455)..(2455)
<223> Selenocysteine

<400> 4637
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Xaa Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Xaa Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Xaa Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Xaa Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Xaa Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Xaa Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Xaa Gly Ile Leu Ala Xaa Val Gly Xaa Glu Phe Asp Leu Arg 
            180                 185                 190         


Xaa Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Xaa Xaa Cys 
                245                 250                 255     


Phe Glu Glu Gly Xaa Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Xaa Glu Glu Pro Ala Arg Xaa Cys Pro Asn Gly Xaa Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Xaa Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp 
305                 310                 315                 320 


Xaa Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Xaa Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Xaa Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Gly Ala Leu Arg Arg Xaa Xaa Ile Lys Lys Ser Lys Xaa Asp 
            420                 425                 430         


Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser 
        435                 440                 445             


Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu 
    450                 455                 460                 


Asn Ser Xaa Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile 
465                 470                 475                 480 


Arg Arg Met Val Lys Xaa Gln Ala Phe Tyr Trp Xaa Val Leu Ser Leu 
                485                 490                 495     


Val Ala Leu Asn Xaa Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro 
            500                 505                 510         


Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly 
        515                 520                 525             


Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Xaa Arg 
    530                 535                 540                 


Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile 
545                 550                 555                 560 


Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Xaa Ser 
                565                 570                 575     


Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys 
            580                 585                 590         


Val Xaa Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu 
        595                 600                 605             


Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe 
    610                 615                 620                 


Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe 
625                 630                 635                 640 


Asn Phe Asp Glu Gly Xaa Pro Pro Xaa Asn Phe Asp Xaa Phe Pro Ala 
                645                 650                 655     


Ala Ile Met Xaa Val Phe Gln Ile Leu Xaa Gly Glu Asp Trp Asn Glu 
            660                 665                 670         


Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met 
        675                 680                 685             


Val Phe Ser Ile Tyr Phe Ile Val Leu Xaa Leu Phe Gly Asn Tyr Xaa 
    690                 695                 700                 


Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala 
705                 710                 715                 720 


Gln Glu Leu Xaa Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln 
                725                 730                 735     


Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu 
            740                 745                 750         


Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln 
        755                 760                 765             


Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Xaa Ser Glu Met Arg Lys 
    770                 775                 780                 


Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro 
785                 790                 795                 800 


Asp Glu Arg Trp Lys Ala Ala Tyr Xaa Arg His Leu Arg Pro Asp Met 
                805                 810                 815     


Lys Xaa His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg 
            820                 825                 830         


Asn Asn Asn Xaa Asn Lys Ser Arg Ala Ala Glu Pro Xaa Val Asp Gln 
        835                 840                 845             


Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg 
    850                 855                 860                 


Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala 
865                 870                 875                 880 


Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly 
                885                 890                 895     


Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu 
            900                 905                 910         


Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp 
        915                 920                 925             


Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg 
    930                 935                 940                 


Ser Gly Ser Pro Arg Xaa Gly Ala Asp Gly Glu His Arg Arg His Arg 
945                 950                 955                 960 


Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg 
                965                 970                 975     


Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly 
            980                 985                 990         


Glu Gly Glu Gly Pro Asp Gly Gly  Glu Arg Arg Arg Arg  His Arg His 
        995                 1000                 1005             


Gly Ala  Pro Ala Xaa Tyr Glu  Gly Asp Ala Arg Arg  Glu Asp Lys 
    1010                 1015                 1020             


Glu Arg  Arg His Arg Arg Arg  Lys Glu Asn Gln Gly  Ser Gly Val 
    1025                 1030                 1035             


Pro Val  Ser Gly Pro Asn Leu  Ser Xaa Xaa Arg Pro  Ile Gln Gln 
    1040                 1045                 1050             


Asp Leu  Gly Arg Gln Asp Pro  Pro Leu Ala Glu Asp  Ile Asp Asn 
    1055                 1060                 1065             


Met Lys  Asn Asn Lys Leu Ala  Xaa Ala Glu Ser Ala  Ala Pro His 
    1070                 1075                 1080             


Gly Ser  Leu Gly His Ala Gly  Leu Pro Gln Ser Pro  Ala Lys Met 
    1085                 1090                 1095             


Gly Asn  Ser Xaa Asp Pro Gly  Pro Met Leu Ala Ile  Pro Ala Met 
    1100                 1105                 1110             


Ala Xaa  Asn Pro Gln Asn Ala  Ala Ser Arg Arg Xaa  Pro Asn Asn 
    1115                 1120                 1125             


Pro Gly  Asn Pro Ser Asn Pro  Gly Pro Pro Lys Xaa  Pro Glu Asn 
    1130                 1135                 1140             


Ser Leu  Ile Val Xaa Asn Pro  Ser Gly Xaa Gln Xaa  Asn Ser Ala 
    1145                 1150                 1155             


Lys Xaa  Ala Arg Lys Pro Asp  His Xaa Xaa Val Asp  Ile Pro Pro 
    1160                 1165                 1170             


Ala Cys  Pro Pro Pro Leu Asn  His Xaa Val Val Gln  Val Asn Lys 
    1175                 1180                 1185             


Asn Ala  Asn Pro Asp Pro Leu  Pro Lys Lys Glu Glu  Glu Lys Lys 
    1190                 1195                 1200             


Glu Glu  Glu Glu Asp Asp Arg  Gly Glu Asp Gly Pro  Lys Pro Met 
    1205                 1210                 1215             


Pro Pro  Tyr Ser Ser Met Phe  Ile Leu Ser Xaa Xaa  Asn Pro Leu 
    1220                 1225                 1230             


Arg Arg  Leu Cys His Tyr Ile  Leu Asn Leu Arg Tyr  Phe Glu Met 
    1235                 1240                 1245             


Cys Ile  Leu Met Val Ile Ala  Met Ser Ser Ile Ala  Leu Ala Ala 
    1250                 1255                 1260             


Glu Asp  Pro Val Gln Pro Asn  Ala Pro Arg Asn Asn  Val Leu Arg 
    1265                 1270                 1275             


Tyr Phe  Asp Tyr Val Phe Xaa  Gly Val Phe Xaa Phe  Glu Met Val 
    1280                 1285                 1290             


Ile Lys  Met Ile Asp Leu Gly  Leu Val Leu His Gln  Gly Ala Tyr 
    1295                 1300                 1305             


Phe Arg  Asp Leu Trp Asn Ile  Leu Asp Phe Ile Val  Val Ser Gly 
    1310                 1315                 1320             


Ala Leu  Val Ala Phe Ala Phe  Xaa Gly Asn Ser Lys  Gly Lys Asp 
    1325                 1330                 1335             


Ile Asn  Xaa Ile Lys Ser Leu  Arg Val Leu Arg Val  Leu Arg Pro 
    1340                 1345                 1350             


Leu Lys  Xaa Ile Lys Arg Leu  Pro Lys Leu Lys Ala  Val Phe Asp 
    1355                 1360                 1365             


Cys Val  Val Asn Ser Leu Lys  Asn Val Phe Asn Ile  Leu Ile Val 
    1370                 1375                 1380             


Tyr Met  Leu Phe Met Phe Ile  Phe Ala Val Val Ala  Val Gln Leu 
    1385                 1390                 1395             


Phe Lys  Gly Lys Phe Phe His  Cys Xaa Asp Glu Ser  Lys Glu Phe 
    1400                 1405                 1410             


Glu Lys  Asp Cys Arg Gly Lys  Tyr Leu Leu Tyr Glu  Lys Asn Glu 
    1415                 1420                 1425             


Val Lys  Ala Arg Asp Arg Glu  Trp Lys Lys Tyr Glu  Phe His Tyr 
    1430                 1435                 1440             


Asp Asn  Val Leu Trp Ala Leu  Leu Xaa Leu Phe Xaa  Val Ser Xaa 
    1445                 1450                 1455             


Gly Glu  Gly Trp Pro Gln Val  Leu Lys His Ser Val  Asp Ala Xaa 
    1460                 1465                 1470             


Phe Glu  Asn Gln Gly Pro Ser  Pro Gly Tyr Arg Met  Glu Met Ser 
    1475                 1480                 1485             


Ile Phe  Tyr Val Val Tyr Phe  Val Val Phe Pro Phe  Phe Phe Val 
    1490                 1495                 1500             


Asn Ile  Phe Val Ala Leu Ile  Ile Ile Xaa Phe Gln  Glu Gln Gly 
    1505                 1510                 1515             


Asp Lys  Met Met Glu Glu Tyr  Ser Leu Glu Lys Asn  Glu Arg Ala 
    1520                 1525                 1530             


Cys Ile  Asp Phe Ala Ile Ser  Ala Lys Pro Leu Xaa  Arg His Met 
    1535                 1540                 1545             


Pro Gln  Asn Lys Gln Ser Phe  Gln Tyr Arg Met Trp  Gln Phe Val 
    1550                 1555                 1560             


Val Ser  Pro Pro Phe Glu Tyr  Xaa Ile Met Ala Met  Ile Ala Leu 
    1565                 1570                 1575             


Asn Xaa  Ile Val Leu Met Met  Lys Phe Tyr Gly Ala  Ser Val Ala 
    1580                 1585                 1590             


Tyr Glu  Asn Ala Leu Arg Val  Phe Asn Ile Val Phe  Xaa Ser Leu 
    1595                 1600                 1605             


Phe Ser  Leu Glu Cys Val Leu  Lys Val Met Ala Phe  Gly Ile Leu 
    1610                 1615                 1620             


Asn Tyr  Phe Arg Asp Ala Trp  Asn Ile Phe Asp Phe  Val Xaa Val 
    1625                 1630                 1635             


Leu Gly  Ser Ile Xaa Asp Ile  Leu Val Xaa Glu Phe  Gly Asn Asn 
    1640                 1645                 1650             


Phe Ile  Asn Leu Ser Phe Leu  Arg Leu Phe Arg Ala  Ala Arg Leu 
    1655                 1660                 1665             


Ile Lys  Leu Leu Arg Gln Gly  Tyr Xaa Ile Arg Ile  Leu Leu Trp 
    1670                 1675                 1680             


Xaa Phe  Val Gln Ser Phe Lys  Ala Leu Pro Tyr Val  Cys Leu Leu 
    1685                 1690                 1695             


Ile Ala  Met Leu Phe Phe Ile  Tyr Ala Ile Ile Gly  Met Gln Val 
    1700                 1705                 1710             


Phe Gly  Asn Ile Gly Ile Asp  Val Glu Asp Glu Asp  Ser Asp Glu 
    1715                 1720                 1725             


Asp Glu  Phe Gln Ile Xaa Glu  His Asn Asn Phe Arg  Xaa Phe Phe 
    1730                 1735                 1740             


Gln Ala  Leu Met Leu Leu Phe  Arg Ser Ala Xaa Gly  Glu Ala Trp 
    1745                 1750                 1755             


His Asn  Ile Met Leu Ser Cys  Leu Ser Gly Lys Pro  Cys Asp Lys 
    1760                 1765                 1770             


Asn Ser  Gly Ile Leu Xaa Arg  Glu Cys Gly Asn Glu  Phe Ala Tyr 
    1775                 1780                 1785             


Phe Tyr  Phe Val Ser Phe Ile  Phe Leu Cys Ser Phe  Leu Met Leu 
    1790                 1795                 1800             


Asn Leu  Phe Val Ala Val Ile  Met Asp Asn Phe Glu  Tyr Leu Xaa 
    1805                 1810                 1815             


Arg Asp  Ser Ser Ile Leu Gly  Pro His His Leu Asp  Glu Tyr Val 
    1820                 1825                 1830             


Arg Val  Trp Ala Glu Tyr Asp  Pro Ala Ala Trp Gly  Arg Met Pro 
    1835                 1840                 1845             


Tyr Leu  Asp Met Tyr Gln Met  Leu Arg His Met Ser  Pro Pro Leu 
    1850                 1855                 1860             


Gly Leu  Gly Lys Lys Cys Pro  Ala Arg Val Ala Tyr  Lys Arg Leu 
    1865                 1870                 1875             


Leu Arg  Met Asp Leu Pro Val  Ala Asp Asp Asn Xaa  Val His Phe 
    1880                 1885                 1890             


Asn Ser  Xaa Leu Met Ala Leu  Ile Arg Xaa Ala Leu  Asp Ile Lys 
    1895                 1900                 1905             


Ile Ala  Lys Gly Gly Ala Asp  Lys Gln Gln Met Asp  Ala Glu Leu 
    1910                 1915                 1920             


Arg Lys  Glu Met Met Ala Ile  Trp Pro Asn Leu Ser  Gln Lys Xaa 
    1925                 1930                 1935             


Leu Asp  Leu Leu Val Xaa Pro  His Lys Ser Xaa Asp  Leu Xaa Val 
    1940                 1945                 1950             


Gly Lys  Ile Tyr Ala Ala Met  Met Ile Met Glu Tyr  Tyr Arg Gln 
    1955                 1960                 1965             


Ser Lys  Ala Lys Lys Leu Gln  Ala Met Arg Glu Glu  Gln Asp Arg 
    1970                 1975                 1980             


Xaa Pro  Leu Met Phe Gln Arg  Met Glu Pro Pro Ser  Pro Xaa Gln 
    1985                 1990                 1995             


Glu Gly  Gly Pro Gly Gln Asn  Ala Leu Pro Ser Xaa  Gln Leu Asp 
    2000                 2005                 2010             


Pro Gly  Gly Ala Leu Met Ala  His Glu Ser Gly Leu  Lys Glu Ser 
    2015                 2020                 2025             


Pro Ser  Trp Val Xaa Gln Arg  Ala Gln Glu Met Phe  Gln Lys Xaa 
    2030                 2035                 2040             


Gly Xaa  Trp Ser Pro Glu Gln  Gly Pro Pro Xaa Asp  Met Pro Asn 
    2045                 2050                 2055             


Ser Gln  Pro Asn Ser Gln Ser  Val Glu Met Arg Glu  Met Gly Arg 
    2060                 2065                 2070             


Asp Gly  Tyr Ser Asp Ser Glu  His Tyr Leu Pro Met  Glu Gly Gln 
    2075                 2080                 2085             


Gly Arg  Ala Ala Ser Met Pro  Arg Leu Pro Ala Glu  Asn Gln Arg 
    2090                 2095                 2100             


Arg Arg  Gly Arg Pro Arg Gly  Asn Asn Leu Ser Xaa  Ile Ser Asp 
    2105                 2110                 2115             


Xaa Ser  Pro Met Lys Arg Ser  Ala Ser Val Leu Gly  Pro Lys Ala 
    2120                 2125                 2130             


Arg Arg  Leu Asp Asp Tyr Ser  Leu Glu Arg Val Pro  Pro Glu Glu 
    2135                 2140                 2145             


Asn Gln  Arg His His Gln Arg  Arg Arg Asp Arg Ser  His Arg Ala 
    2150                 2155                 2160             


Ser Glu  Arg Ser Leu Gly Arg  Tyr Xaa Asp Val Asp  Xaa Gly Leu 
    2165                 2170                 2175             


Gly Xaa  Asp Leu Ser Met Xaa  Xaa Gln Ser Gly Asp  Leu Pro Ser 
    2180                 2185                 2190             


Lys Glu  Arg Asp Gln Glu Arg  Gly Arg Pro Lys Asp  Arg Lys His 
    2195                 2200                 2205             


Arg Gln  His His His His His  His His His His His  Pro Pro Pro 
    2210                 2215                 2220             


Pro Asp  Lys Asp Arg Tyr Ala  Gln Glu Arg Pro Asp  His Gly Arg 
    2225                 2230                 2235             


Ala Arg  Ala Arg Asp Gln Arg  Trp Ser Arg Ser Pro  Ser Glu Gly 
    2240                 2245                 2250             


Arg Glu  His Met Ala His Arg  Gln Gly Ser Ser Ser  Val Ser Gly 
    2255                 2260                 2265             


Ser Pro  Ala Pro Ser Xaa Ser  Gly Xaa Ser Xaa Pro  Arg Arg Gly 
    2270                 2275                 2280             


Arg Arg  Gln Leu Pro Gln Xaa  Pro Ser Xaa Pro Arg  Pro His Val 
    2285                 2290                 2295             


Ser Tyr  Ser Pro Val Ile Arg  Lys Ala Gly Gly Ser  Gly Pro Pro 
    2300                 2305                 2310             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Ala Val 
    2315                 2320                 2325             


Ala Arg  Pro Gly Arg Ala Ala  Xaa Ser Gly Pro Arg  Arg Tyr Pro 
    2330                 2335                 2340             


Gly Pro  Xaa Ala Glu Pro Leu  Ala Gly Asp Arg Pro  Pro Xaa Gly 
    2345                 2350                 2355             


Gly His  Ser Ser Gly Arg Ser  Pro Arg Met Glu Arg  Arg Val Pro 
    2360                 2365                 2370             


Gly Pro  Ala Arg Ser Glu Ser  Pro Arg Ala Cys Arg  His Gly Gly 
    2375                 2380                 2385             


Ala Arg  Trp Pro Ala Ser Gly  Pro His Val Ser Glu  Gly Pro Pro 
    2390                 2395                 2400             


Gly Pro  Arg His His Gly Tyr  Tyr Arg Gly Ser Asp  Tyr Asp Glu 
    2405                 2410                 2415             


Ala Asp  Gly Pro Gly Ser Gly  Gly Gly Glu Glu Ala  Met Ala Gly 
    2420                 2425                 2430             


Ala Tyr  Asp Ala Pro Pro Pro  Val Arg His Ala Ser  Ser Gly Ala 
    2435                 2440                 2445             


Xaa Gly  Arg Ser Pro Arg Xaa  Pro Arg Ala Ser Gly  Pro Ala Cys 
    2450                 2455                 2460             


Ala Ser  Pro Ser Arg His Gly  Arg Arg Leu Pro Asn  Gly Tyr Tyr 
    2465                 2470                 2475             


Pro Ala  His Gly Leu Ala Arg  Pro Arg Gly Pro Gly  Ser Arg Lys 
    2480                 2485                 2490             


Gly Leu  His Glu Pro Tyr Ser  Glu Ser Asp Asp Asp  Trp Cys 
    2495                 2500                 2505         


<210> 4638
<211> 2508
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1103)..(1103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1161)..(1161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1342)..(1342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1357)..(1357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1453)..(1453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1456)..(1456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1459)..(1459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1474)..(1474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1514)..(1514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1546)..(1546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1572)..(1572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1581)..(1581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1638)..(1638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1644)..(1644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1649)..(1649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1678)..(1678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1685)..(1685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1735)..(1735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1742)..(1742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1755)..(1755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1780)..(1780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1819)..(1819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1891)..(1891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1897)..(1897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1904)..(1904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1939)..(1939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1945)..(1945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1950)..(1950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1953)..(1953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1985)..(1985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1998)..(1998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2011)..(2011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2034)..(2034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2044)..(2044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2046)..(2046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2055)..(2055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2116)..(2116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2120)..(2120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2173)..(2173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2177)..(2177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2181)..(2181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2186)..(2187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2275)..(2275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2278)..(2278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2280)..(2280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2291)..(2291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2294)..(2294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2337)..(2337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2347)..(2347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2358)..(2358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2450)..(2450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2456)..(2456)
<223> Selenocysteine

<400> 4638
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Xaa Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Xaa Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Xaa Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Xaa Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Xaa Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Xaa Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Xaa Gly Ile Leu Ala Xaa Val Gly Xaa Glu Phe Asp Leu Arg 
            180                 185                 190         


Xaa Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Xaa Xaa Cys 
                245                 250                 255     


Phe Glu Glu Gly Xaa Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Xaa Glu Glu Pro Ala Arg Xaa Cys Pro Asn Gly Xaa Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Xaa Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp 
305                 310                 315                 320 


Xaa Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Xaa Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Xaa Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Val Gly Ala Leu Arg Arg Xaa Xaa Ile Lys Lys Ser Lys Xaa 
            420                 425                 430         


Asp Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala 
        435                 440                 445             


Ser Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu 
    450                 455                 460                 


Glu Asn Ser Xaa Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr 
465                 470                 475                 480 


Ile Arg Arg Met Val Lys Xaa Gln Ala Phe Tyr Trp Xaa Val Leu Ser 
                485                 490                 495     


Leu Val Ala Leu Asn Xaa Leu Cys Val Ala Ile Val His Tyr Asn Gln 
            500                 505                 510         


Pro Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu 
        515                 520                 525             


Gly Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Xaa 
    530                 535                 540                 


Arg Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile 
545                 550                 555                 560 


Ile Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Xaa 
                565                 570                 575     


Ser Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe 
            580                 585                 590         


Lys Val Xaa Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu 
        595                 600                 605             


Leu Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu 
    610                 615                 620                 


Phe Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln 
625                 630                 635                 640 


Phe Asn Phe Asp Glu Gly Xaa Pro Pro Xaa Asn Phe Asp Xaa Phe Pro 
                645                 650                 655     


Ala Ala Ile Met Xaa Val Phe Gln Ile Leu Xaa Gly Glu Asp Trp Asn 
            660                 665                 670         


Glu Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly 
        675                 680                 685             


Met Val Phe Ser Ile Tyr Phe Ile Val Leu Xaa Leu Phe Gly Asn Tyr 
    690                 695                 700                 


Xaa Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn 
705                 710                 715                 720 


Ala Gln Glu Leu Xaa Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn 
                725                 730                 735     


Gln Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro 
            740                 745                 750         


Leu Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn 
        755                 760                 765             


Gln Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Xaa Ser Glu Met Arg 
    770                 775                 780                 


Lys Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp 
785                 790                 795                 800 


Pro Asp Glu Arg Trp Lys Ala Ala Tyr Xaa Arg His Leu Arg Pro Asp 
                805                 810                 815     


Met Lys Xaa His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn 
            820                 825                 830         


Arg Asn Asn Asn Xaa Asn Lys Ser Arg Ala Ala Glu Pro Xaa Val Asp 
        835                 840                 845             


Gln Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala 
    850                 855                 860                 


Arg Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp 
865                 870                 875                 880 


Ala Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu 
                885                 890                 895     


Gly Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu 
            900                 905                 910         


Glu Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly 
        915                 920                 925             


Asp Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser 
    930                 935                 940                 


Arg Ser Gly Ser Pro Arg Xaa Gly Ala Asp Gly Glu His Arg Arg His 
945                 950                 955                 960 


Arg Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu 
                965                 970                 975     


Arg Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu 
            980                 985                 990         


Gly Glu Gly Glu Gly Pro Asp Gly  Gly Glu Arg Arg Arg  Arg His Arg 
        995                 1000                 1005             


His Gly  Ala Pro Ala Xaa Tyr  Glu Gly Asp Ala Arg  Arg Glu Asp 
    1010                 1015                 1020             


Lys Glu  Arg Arg His Arg Arg  Arg Lys Glu Asn Gln  Gly Ser Gly 
    1025                 1030                 1035             


Val Pro  Val Ser Gly Pro Asn  Leu Ser Xaa Xaa Arg  Pro Ile Gln 
    1040                 1045                 1050             


Gln Asp  Leu Gly Arg Gln Asp  Pro Pro Leu Ala Glu  Asp Ile Asp 
    1055                 1060                 1065             


Asn Met  Lys Asn Asn Lys Leu  Ala Xaa Ala Glu Ser  Ala Ala Pro 
    1070                 1075                 1080             


His Gly  Ser Leu Gly His Ala  Gly Leu Pro Gln Ser  Pro Ala Lys 
    1085                 1090                 1095             


Met Gly  Asn Ser Xaa Asp Pro  Gly Pro Met Leu Ala  Ile Pro Ala 
    1100                 1105                 1110             


Met Ala  Xaa Asn Pro Gln Asn  Ala Ala Ser Arg Arg  Xaa Pro Asn 
    1115                 1120                 1125             


Asn Pro  Gly Asn Pro Ser Asn  Pro Gly Pro Pro Lys  Xaa Pro Glu 
    1130                 1135                 1140             


Asn Ser  Leu Ile Val Xaa Asn  Pro Ser Gly Xaa Gln  Xaa Asn Ser 
    1145                 1150                 1155             


Ala Lys  Xaa Ala Arg Lys Pro  Asp His Xaa Xaa Val  Asp Ile Pro 
    1160                 1165                 1170             


Pro Ala  Cys Pro Pro Pro Leu  Asn His Xaa Val Val  Gln Val Asn 
    1175                 1180                 1185             


Lys Asn  Ala Asn Pro Asp Pro  Leu Pro Lys Lys Glu  Glu Glu Lys 
    1190                 1195                 1200             


Lys Glu  Glu Glu Glu Asp Asp  Arg Gly Glu Asp Gly  Pro Lys Pro 
    1205                 1210                 1215             


Met Pro  Pro Tyr Ser Ser Met  Phe Ile Leu Ser Xaa  Xaa Asn Pro 
    1220                 1225                 1230             


Leu Arg  Arg Leu Cys His Tyr  Ile Leu Asn Leu Arg  Tyr Phe Glu 
    1235                 1240                 1245             


Met Cys  Ile Leu Met Val Ile  Ala Met Ser Ser Ile  Ala Leu Ala 
    1250                 1255                 1260             


Ala Glu  Asp Pro Val Gln Pro  Asn Ala Pro Arg Asn  Asn Val Leu 
    1265                 1270                 1275             


Arg Tyr  Phe Asp Tyr Val Phe  Xaa Gly Val Phe Xaa  Phe Glu Met 
    1280                 1285                 1290             


Val Ile  Lys Met Ile Asp Leu  Gly Leu Val Leu His  Gln Gly Ala 
    1295                 1300                 1305             


Tyr Phe  Arg Asp Leu Trp Asn  Ile Leu Asp Phe Ile  Val Val Ser 
    1310                 1315                 1320             


Gly Ala  Leu Val Ala Phe Ala  Phe Xaa Gly Asn Ser  Lys Gly Lys 
    1325                 1330                 1335             


Asp Ile  Asn Xaa Ile Lys Ser  Leu Arg Val Leu Arg  Val Leu Arg 
    1340                 1345                 1350             


Pro Leu  Lys Xaa Ile Lys Arg  Leu Pro Lys Leu Lys  Ala Val Phe 
    1355                 1360                 1365             


Asp Cys  Val Val Asn Ser Leu  Lys Asn Val Phe Asn  Ile Leu Ile 
    1370                 1375                 1380             


Val Tyr  Met Leu Phe Met Phe  Ile Phe Ala Val Val  Ala Val Gln 
    1385                 1390                 1395             


Leu Phe  Lys Gly Lys Phe Phe  His Cys Xaa Asp Glu  Ser Lys Glu 
    1400                 1405                 1410             


Phe Glu  Lys Asp Cys Arg Gly  Lys Tyr Leu Leu Tyr  Glu Lys Asn 
    1415                 1420                 1425             


Glu Val  Lys Ala Arg Asp Arg  Glu Trp Lys Lys Tyr  Glu Phe His 
    1430                 1435                 1440             


Tyr Asp  Asn Val Leu Trp Ala  Leu Leu Xaa Leu Phe  Xaa Val Ser 
    1445                 1450                 1455             


Xaa Gly  Glu Gly Trp Pro Gln  Val Leu Lys His Ser  Val Asp Ala 
    1460                 1465                 1470             


Xaa Phe  Glu Asn Gln Gly Pro  Ser Pro Gly Tyr Arg  Met Glu Met 
    1475                 1480                 1485             


Ser Ile  Phe Tyr Val Val Tyr  Phe Val Val Phe Pro  Phe Phe Phe 
    1490                 1495                 1500             


Val Asn  Ile Phe Val Ala Leu  Ile Ile Ile Xaa Phe  Gln Glu Gln 
    1505                 1510                 1515             


Gly Asp  Lys Met Met Glu Glu  Tyr Ser Leu Glu Lys  Asn Glu Arg 
    1520                 1525                 1530             


Ala Cys  Ile Asp Phe Ala Ile  Ser Ala Lys Pro Leu  Xaa Arg His 
    1535                 1540                 1545             


Met Pro  Gln Asn Lys Gln Ser  Phe Gln Tyr Arg Met  Trp Gln Phe 
    1550                 1555                 1560             


Val Val  Ser Pro Pro Phe Glu  Tyr Xaa Ile Met Ala  Met Ile Ala 
    1565                 1570                 1575             


Leu Asn  Xaa Ile Val Leu Met  Met Lys Phe Tyr Gly  Ala Ser Val 
    1580                 1585                 1590             


Ala Tyr  Glu Asn Ala Leu Arg  Val Phe Asn Ile Val  Phe Xaa Ser 
    1595                 1600                 1605             


Leu Phe  Ser Leu Glu Cys Val  Leu Lys Val Met Ala  Phe Gly Ile 
    1610                 1615                 1620             


Leu Asn  Tyr Phe Arg Asp Ala  Trp Asn Ile Phe Asp  Phe Val Xaa 
    1625                 1630                 1635             


Val Leu  Gly Ser Ile Xaa Asp  Ile Leu Val Xaa Glu  Phe Gly Asn 
    1640                 1645                 1650             


Asn Phe  Ile Asn Leu Ser Phe  Leu Arg Leu Phe Arg  Ala Ala Arg 
    1655                 1660                 1665             


Leu Ile  Lys Leu Leu Arg Gln  Gly Tyr Xaa Ile Arg  Ile Leu Leu 
    1670                 1675                 1680             


Trp Xaa  Phe Val Gln Ser Phe  Lys Ala Leu Pro Tyr  Val Cys Leu 
    1685                 1690                 1695             


Leu Ile  Ala Met Leu Phe Phe  Ile Tyr Ala Ile Ile  Gly Met Gln 
    1700                 1705                 1710             


Val Phe  Gly Asn Ile Gly Ile  Asp Val Glu Asp Glu  Asp Ser Asp 
    1715                 1720                 1725             


Glu Asp  Glu Phe Gln Ile Xaa  Glu His Asn Asn Phe  Arg Xaa Phe 
    1730                 1735                 1740             


Phe Gln  Ala Leu Met Leu Leu  Phe Arg Ser Ala Xaa  Gly Glu Ala 
    1745                 1750                 1755             


Trp His  Asn Ile Met Leu Ser  Cys Leu Ser Gly Lys  Pro Cys Asp 
    1760                 1765                 1770             


Lys Asn  Ser Gly Ile Leu Xaa  Arg Glu Cys Gly Asn  Glu Phe Ala 
    1775                 1780                 1785             


Tyr Phe  Tyr Phe Val Ser Phe  Ile Phe Leu Cys Ser  Phe Leu Met 
    1790                 1795                 1800             


Leu Asn  Leu Phe Val Ala Val  Ile Met Asp Asn Phe  Glu Tyr Leu 
    1805                 1810                 1815             


Xaa Arg  Asp Ser Ser Ile Leu  Gly Pro His His Leu  Asp Glu Tyr 
    1820                 1825                 1830             


Val Arg  Val Trp Ala Glu Tyr  Asp Pro Ala Ala Cys  Gly Arg Ile 
    1835                 1840                 1845             


His Tyr  Lys Asp Met Tyr Ser  Leu Leu Arg Val Ile  Ser Pro Pro 
    1850                 1855                 1860             


Leu Gly  Leu Gly Lys Lys Cys  Pro His Arg Val Ala  Cys Lys Arg 
    1865                 1870                 1875             


Leu Leu  Arg Met Asp Leu Pro  Val Ala Asp Asp Asn  Xaa Val His 
    1880                 1885                 1890             


Phe Asn  Ser Xaa Leu Met Ala  Leu Ile Arg Xaa Ala  Leu Asp Ile 
    1895                 1900                 1905             


Lys Ile  Ala Lys Gly Gly Ala  Asp Lys Gln Gln Met  Asp Ala Glu 
    1910                 1915                 1920             


Leu Arg  Lys Glu Met Met Ala  Ile Trp Pro Asn Leu  Ser Gln Lys 
    1925                 1930                 1935             


Xaa Leu  Asp Leu Leu Val Xaa  Pro His Lys Ser Xaa  Asp Leu Xaa 
    1940                 1945                 1950             


Val Gly  Lys Ile Tyr Ala Ala  Met Met Ile Met Glu  Tyr Tyr Arg 
    1955                 1960                 1965             


Gln Ser  Lys Ala Lys Lys Leu  Gln Ala Met Arg Glu  Glu Gln Asp 
    1970                 1975                 1980             


Arg Xaa  Pro Leu Met Phe Gln  Arg Met Glu Pro Pro  Ser Pro Xaa 
    1985                 1990                 1995             


Gln Glu  Gly Gly Pro Gly Gln  Asn Ala Leu Pro Ser  Xaa Gln Leu 
    2000                 2005                 2010             


Asp Pro  Gly Gly Ala Leu Met  Ala His Glu Ser Gly  Leu Lys Glu 
    2015                 2020                 2025             


Ser Pro  Ser Trp Val Xaa Gln  Arg Ala Gln Glu Met  Phe Gln Lys 
    2030                 2035                 2040             


Xaa Gly  Xaa Trp Ser Pro Glu  Gln Gly Pro Pro Xaa  Asp Met Pro 
    2045                 2050                 2055             


Asn Ser  Gln Pro Asn Ser Gln  Ser Val Glu Met Arg  Glu Met Gly 
    2060                 2065                 2070             


Arg Asp  Gly Tyr Ser Asp Ser  Glu His Tyr Leu Pro  Met Glu Gly 
    2075                 2080                 2085             


Gln Gly  Arg Ala Ala Ser Met  Pro Arg Leu Pro Ala  Glu Asn Gln 
    2090                 2095                 2100             


Arg Arg  Arg Gly Arg Pro Arg  Gly Asn Asn Leu Ser  Xaa Ile Ser 
    2105                 2110                 2115             


Asp Xaa  Ser Pro Met Lys Arg  Ser Ala Ser Val Leu  Gly Pro Lys 
    2120                 2125                 2130             


Ala Arg  Arg Leu Asp Asp Tyr  Ser Leu Glu Arg Val  Pro Pro Glu 
    2135                 2140                 2145             


Glu Asn  Gln Arg His His Gln  Arg Arg Arg Asp Arg  Ser His Arg 
    2150                 2155                 2160             


Ala Ser  Glu Arg Ser Leu Gly  Arg Tyr Xaa Asp Val  Asp Xaa Gly 
    2165                 2170                 2175             


Leu Gly  Xaa Asp Leu Ser Met  Xaa Xaa Gln Ser Gly  Asp Leu Pro 
    2180                 2185                 2190             


Ser Lys  Glu Arg Asp Gln Glu  Arg Gly Arg Pro Lys  Asp Arg Lys 
    2195                 2200                 2205             


His Arg  Gln His His His His  His His His His His  His Pro Pro 
    2210                 2215                 2220             


Pro Pro  Asp Lys Asp Arg Tyr  Ala Gln Glu Arg Pro  Asp His Gly 
    2225                 2230                 2235             


Arg Ala  Arg Ala Arg Asp Gln  Arg Trp Ser Arg Ser  Pro Ser Glu 
    2240                 2245                 2250             


Gly Arg  Glu His Met Ala His  Arg Gln Gly Ser Ser  Ser Val Ser 
    2255                 2260                 2265             


Gly Ser  Pro Ala Pro Ser Xaa  Ser Gly Xaa Ser Xaa  Pro Arg Arg 
    2270                 2275                 2280             


Gly Arg  Arg Gln Leu Pro Gln  Xaa Pro Ser Xaa Pro  Arg Pro His 
    2285                 2290                 2295             


Val Ser  Tyr Ser Pro Val Ile  Arg Lys Ala Gly Gly  Ser Gly Pro 
    2300                 2305                 2310             


Pro Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Ala 
    2315                 2320                 2325             


Val Ala  Arg Pro Gly Arg Ala  Ala Xaa Ser Gly Pro  Arg Arg Tyr 
    2330                 2335                 2340             


Pro Gly  Pro Xaa Ala Glu Pro  Leu Ala Gly Asp Arg  Pro Pro Xaa 
    2345                 2350                 2355             


Gly Gly  His Ser Ser Gly Arg  Ser Pro Arg Met Glu  Arg Arg Val 
    2360                 2365                 2370             


Pro Gly  Pro Ala Arg Ser Glu  Ser Pro Arg Ala Cys  Arg His Gly 
    2375                 2380                 2385             


Gly Ala  Arg Trp Pro Ala Ser  Gly Pro His Val Ser  Glu Gly Pro 
    2390                 2395                 2400             


Pro Gly  Pro Arg His His Gly  Tyr Tyr Arg Gly Ser  Asp Tyr Asp 
    2405                 2410                 2415             


Glu Ala  Asp Gly Pro Gly Ser  Gly Gly Gly Glu Glu  Ala Met Ala 
    2420                 2425                 2430             


Gly Ala  Tyr Asp Ala Pro Pro  Pro Val Arg His Ala  Ser Ser Gly 
    2435                 2440                 2445             


Ala Xaa  Gly Arg Ser Pro Arg  Xaa Pro Arg Ala Ser  Gly Pro Ala 
    2450                 2455                 2460             


Cys Ala  Ser Pro Ser Arg His  Gly Arg Arg Leu Pro  Asn Gly Tyr 
    2465                 2470                 2475             


Tyr Pro  Ala His Gly Leu Ala  Arg Pro Arg Gly Pro  Gly Ser Arg 
    2480                 2485                 2490             


Lys Gly  Leu His Glu Pro Tyr  Ser Glu Ser Asp Asp  Asp Trp Cys 
    2495                 2500                 2505             


<210> 4639
<211> 2512
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1105)..(1105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1128)..(1128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1344)..(1344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1359)..(1359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1410)..(1410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1461)..(1461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1476)..(1476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1516)..(1516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1548)..(1548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1583)..(1583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1651)..(1651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1682)..(1682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1689)..(1689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1739)..(1739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1746)..(1746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1759)..(1759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1784)..(1784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1823)..(1823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1895)..(1895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1901)..(1901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1908)..(1908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1943)..(1943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1949)..(1949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1954)..(1954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1957)..(1957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1989)..(1989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2002)..(2002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2015)..(2015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2038)..(2038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2048)..(2048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2050)..(2050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2059)..(2059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2120)..(2120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2124)..(2124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2177)..(2177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2181)..(2181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2185)..(2185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2190)..(2191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2279)..(2279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2282)..(2282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2284)..(2284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2295)..(2295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2298)..(2298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2341)..(2341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2351)..(2351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2362)..(2362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2454)..(2454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2460)..(2460)
<223> Selenocysteine

<400> 4639
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Xaa Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Xaa Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Xaa Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Xaa Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Xaa Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Xaa Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Xaa Gly Ile Leu Ala Xaa Val Gly Xaa Glu Phe Asp Leu Arg 
            180                 185                 190         


Xaa Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Xaa Xaa Cys 
                245                 250                 255     


Phe Glu Glu Gly Xaa Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Xaa Glu Glu Pro Ala Arg Xaa Cys Pro Asn Gly Xaa Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Xaa Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp 
305                 310                 315                 320 


Xaa Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Xaa Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Xaa Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Gly Ala Leu Arg Arg Xaa Xaa Ile Lys Lys Ser Lys Xaa Asp 
            420                 425                 430         


Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser 
        435                 440                 445             


Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu 
    450                 455                 460                 


Asn Ser Xaa Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile 
465                 470                 475                 480 


Arg Arg Met Val Lys Xaa Gln Ala Phe Tyr Trp Xaa Val Leu Ser Leu 
                485                 490                 495     


Val Ala Leu Asn Xaa Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro 
            500                 505                 510         


Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly 
        515                 520                 525             


Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Xaa Arg 
    530                 535                 540                 


Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile 
545                 550                 555                 560 


Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Xaa Ser 
                565                 570                 575     


Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys 
            580                 585                 590         


Val Xaa Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu 
        595                 600                 605             


Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe 
    610                 615                 620                 


Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe 
625                 630                 635                 640 


Asn Phe Asp Glu Gly Xaa Pro Pro Xaa Asn Phe Asp Xaa Phe Pro Ala 
                645                 650                 655     


Ala Ile Met Xaa Val Phe Gln Ile Leu Xaa Gly Glu Asp Trp Asn Glu 
            660                 665                 670         


Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met 
        675                 680                 685             


Val Phe Ser Ile Tyr Phe Ile Val Leu Xaa Leu Phe Gly Asn Tyr Xaa 
    690                 695                 700                 


Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala 
705                 710                 715                 720 


Gln Glu Leu Xaa Lys Val Glu Ala Asp Glu Gln Glu Glu Glu Glu Ala 
                725                 730                 735     


Ala Asn Gln Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val 
            740                 745                 750         


Ser Pro Leu Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln 
        755                 760                 765             


Lys Asn Gln Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Xaa Ser Glu 
    770                 775                 780                 


Met Arg Lys Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu 
785                 790                 795                 800 


Met Asp Pro Asp Glu Arg Trp Lys Ala Ala Tyr Xaa Arg His Leu Arg 
                805                 810                 815     


Pro Asp Met Lys Xaa His Leu Asp Arg Pro Leu Val Val Asp Pro Gln 
            820                 825                 830         


Glu Asn Arg Asn Asn Asn Xaa Asn Lys Ser Arg Ala Ala Glu Pro Xaa 
        835                 840                 845             


Val Asp Gln Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys 
    850                 855                 860                 


Gln Ala Arg Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly 
865                 870                 875                 880 


Leu Asp Ala Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser 
                885                 890                 895     


Arg Glu Gly Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly 
            900                 905                 910         


Ser Leu Glu Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys 
        915                 920                 925             


Ala Gly Asp Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg 
    930                 935                 940                 


Glu Ser Arg Ser Gly Ser Pro Arg Xaa Gly Ala Asp Gly Glu His Arg 
945                 950                 955                 960 


Arg His Arg Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys 
                965                 970                 975     


Ala Glu Arg Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly 
            980                 985                 990         


Gly Glu Gly Glu Gly Glu Gly Pro  Asp Gly Gly Glu Arg  Arg Arg Arg 
        995                 1000                 1005             


His Arg  His Gly Ala Pro Ala  Xaa Tyr Glu Gly Asp  Ala Arg Arg 
    1010                 1015                 1020             


Glu Asp  Lys Glu Arg Arg His  Arg Arg Arg Lys Glu  Asn Gln Gly 
    1025                 1030                 1035             


Ser Gly  Val Pro Val Ser Gly  Pro Asn Leu Ser Xaa  Xaa Arg Pro 
    1040                 1045                 1050             


Ile Gln  Gln Asp Leu Gly Arg  Gln Asp Pro Pro Leu  Ala Glu Asp 
    1055                 1060                 1065             


Ile Asp  Asn Met Lys Asn Asn  Lys Leu Ala Xaa Ala  Glu Ser Ala 
    1070                 1075                 1080             


Ala Pro  His Gly Ser Leu Gly  His Ala Gly Leu Pro  Gln Ser Pro 
    1085                 1090                 1095             


Ala Lys  Met Gly Asn Ser Xaa  Asp Pro Gly Pro Met  Leu Ala Ile 
    1100                 1105                 1110             


Pro Ala  Met Ala Xaa Asn Pro  Gln Asn Ala Ala Ser  Arg Arg Xaa 
    1115                 1120                 1125             


Pro Asn  Asn Pro Gly Asn Pro  Ser Asn Pro Gly Pro  Pro Lys Xaa 
    1130                 1135                 1140             


Pro Glu  Asn Ser Leu Ile Val  Xaa Asn Pro Ser Gly  Xaa Gln Xaa 
    1145                 1150                 1155             


Asn Ser  Ala Lys Xaa Ala Arg  Lys Pro Asp His Xaa  Xaa Val Asp 
    1160                 1165                 1170             


Ile Pro  Pro Ala Cys Pro Pro  Pro Leu Asn His Xaa  Val Val Gln 
    1175                 1180                 1185             


Val Asn  Lys Asn Ala Asn Pro  Asp Pro Leu Pro Lys  Lys Glu Glu 
    1190                 1195                 1200             


Glu Lys  Lys Glu Glu Glu Glu  Asp Asp Arg Gly Glu  Asp Gly Pro 
    1205                 1210                 1215             


Lys Pro  Met Pro Pro Tyr Ser  Ser Met Phe Ile Leu  Ser Xaa Xaa 
    1220                 1225                 1230             


Asn Pro  Leu Arg Arg Leu Cys  His Tyr Ile Leu Asn  Leu Arg Tyr 
    1235                 1240                 1245             


Phe Glu  Met Cys Ile Leu Met  Val Ile Ala Met Ser  Ser Ile Ala 
    1250                 1255                 1260             


Leu Ala  Ala Glu Asp Pro Val  Gln Pro Asn Ala Pro  Arg Asn Asn 
    1265                 1270                 1275             


Val Leu  Arg Tyr Phe Asp Tyr  Val Phe Xaa Gly Val  Phe Xaa Phe 
    1280                 1285                 1290             


Glu Met  Val Ile Lys Met Ile  Asp Leu Gly Leu Val  Leu His Gln 
    1295                 1300                 1305             


Gly Ala  Tyr Phe Arg Asp Leu  Trp Asn Ile Leu Asp  Phe Ile Val 
    1310                 1315                 1320             


Val Ser  Gly Ala Leu Val Ala  Phe Ala Phe Xaa Gly  Asn Ser Lys 
    1325                 1330                 1335             


Gly Lys  Asp Ile Asn Xaa Ile  Lys Ser Leu Arg Val  Leu Arg Val 
    1340                 1345                 1350             


Leu Arg  Pro Leu Lys Xaa Ile  Lys Arg Leu Pro Lys  Leu Lys Ala 
    1355                 1360                 1365             


Val Phe  Asp Cys Val Val Asn  Ser Leu Lys Asn Val  Phe Asn Ile 
    1370                 1375                 1380             


Leu Ile  Val Tyr Met Leu Phe  Met Phe Ile Phe Ala  Val Val Ala 
    1385                 1390                 1395             


Val Gln  Leu Phe Lys Gly Lys  Phe Phe His Cys Xaa  Asp Glu Ser 
    1400                 1405                 1410             


Lys Glu  Phe Glu Lys Asp Cys  Arg Gly Lys Tyr Leu  Leu Tyr Glu 
    1415                 1420                 1425             


Lys Asn  Glu Val Lys Ala Arg  Asp Arg Glu Trp Lys  Lys Tyr Glu 
    1430                 1435                 1440             


Phe His  Tyr Asp Asn Val Leu  Trp Ala Leu Leu Xaa  Leu Phe Xaa 
    1445                 1450                 1455             


Val Ser  Xaa Gly Glu Gly Trp  Pro Gln Val Leu Lys  His Ser Val 
    1460                 1465                 1470             


Asp Ala  Xaa Phe Glu Asn Gln  Gly Pro Ser Pro Gly  Tyr Arg Met 
    1475                 1480                 1485             


Glu Met  Ser Ile Phe Tyr Val  Val Tyr Phe Val Val  Phe Pro Phe 
    1490                 1495                 1500             


Phe Phe  Val Asn Ile Phe Val  Ala Leu Ile Ile Ile  Xaa Phe Gln 
    1505                 1510                 1515             


Glu Gln  Gly Asp Lys Met Met  Glu Glu Tyr Ser Leu  Glu Lys Asn 
    1520                 1525                 1530             


Glu Arg  Ala Cys Ile Asp Phe  Ala Ile Ser Ala Lys  Pro Leu Xaa 
    1535                 1540                 1545             


Arg His  Met Pro Gln Asn Lys  Gln Ser Phe Gln Tyr  Arg Met Trp 
    1550                 1555                 1560             


Gln Phe  Val Val Ser Pro Pro  Phe Glu Tyr Xaa Ile  Met Ala Met 
    1565                 1570                 1575             


Ile Ala  Leu Asn Xaa Ile Val  Leu Met Met Lys Phe  Tyr Gly Ala 
    1580                 1585                 1590             


Ser Val  Ala Tyr Glu Asn Ala  Leu Arg Val Phe Asn  Ile Val Phe 
    1595                 1600                 1605             


Xaa Ser  Leu Phe Ser Leu Glu  Cys Val Leu Lys Val  Met Ala Phe 
    1610                 1615                 1620             


Gly Ile  Leu Asn Tyr Phe Arg  Asp Ala Trp Asn Ile  Phe Asp Phe 
    1625                 1630                 1635             


Val Xaa  Val Leu Gly Ser Ile  Xaa Asp Ile Leu Val  Xaa Glu Phe 
    1640                 1645                 1650             


Gly Asn  Pro Asn Asn Phe Ile  Asn Leu Ser Phe Leu  Arg Leu Phe 
    1655                 1660                 1665             


Arg Ala  Ala Arg Leu Ile Lys  Leu Leu Arg Gln Gly  Tyr Xaa Ile 
    1670                 1675                 1680             


Arg Ile  Leu Leu Trp Xaa Phe  Val Gln Ser Phe Lys  Ala Leu Pro 
    1685                 1690                 1695             


Tyr Val  Cys Leu Leu Ile Ala  Met Leu Phe Phe Ile  Tyr Ala Ile 
    1700                 1705                 1710             


Ile Gly  Met Gln Val Phe Gly  Asn Ile Gly Ile Asp  Val Glu Asp 
    1715                 1720                 1725             


Glu Asp  Ser Asp Glu Asp Glu  Phe Gln Ile Xaa Glu  His Asn Asn 
    1730                 1735                 1740             


Phe Arg  Xaa Phe Phe Gln Ala  Leu Met Leu Leu Phe  Arg Ser Ala 
    1745                 1750                 1755             


Xaa Gly  Glu Ala Trp His Asn  Ile Met Leu Ser Cys  Leu Ser Gly 
    1760                 1765                 1770             


Lys Pro  Cys Asp Lys Asn Ser  Gly Ile Leu Xaa Arg  Glu Cys Gly 
    1775                 1780                 1785             


Asn Glu  Phe Ala Tyr Phe Tyr  Phe Val Ser Phe Ile  Phe Leu Cys 
    1790                 1795                 1800             


Ser Phe  Leu Met Leu Asn Leu  Phe Val Ala Val Ile  Met Asp Asn 
    1805                 1810                 1815             


Phe Glu  Tyr Leu Xaa Arg Asp  Ser Ser Ile Leu Gly  Pro His His 
    1820                 1825                 1830             


Leu Asp  Glu Tyr Val Arg Val  Trp Ala Glu Tyr Asp  Pro Ala Ala 
    1835                 1840                 1845             


Trp Gly  Arg Met Pro Tyr Leu  Asp Met Tyr Gln Met  Leu Arg His 
    1850                 1855                 1860             


Met Ser  Pro Pro Leu Gly Leu  Gly Lys Lys Cys Pro  Ala Arg Val 
    1865                 1870                 1875             


Ala Tyr  Lys Arg Leu Leu Arg  Met Asp Leu Pro Val  Ala Asp Asp 
    1880                 1885                 1890             


Asn Xaa  Val His Phe Asn Ser  Xaa Leu Met Ala Leu  Ile Arg Xaa 
    1895                 1900                 1905             


Ala Leu  Asp Ile Lys Ile Ala  Lys Gly Gly Ala Asp  Lys Gln Gln 
    1910                 1915                 1920             


Met Asp  Ala Glu Leu Arg Lys  Glu Met Met Ala Ile  Trp Pro Asn 
    1925                 1930                 1935             


Leu Ser  Gln Lys Xaa Leu Asp  Leu Leu Val Xaa Pro  His Lys Ser 
    1940                 1945                 1950             


Xaa Asp  Leu Xaa Val Gly Lys  Ile Tyr Ala Ala Met  Met Ile Met 
    1955                 1960                 1965             


Glu Tyr  Tyr Arg Gln Ser Lys  Ala Lys Lys Leu Gln  Ala Met Arg 
    1970                 1975                 1980             


Glu Glu  Gln Asp Arg Xaa Pro  Leu Met Phe Gln Arg  Met Glu Pro 
    1985                 1990                 1995             


Pro Ser  Pro Xaa Gln Glu Gly  Gly Pro Gly Gln Asn  Ala Leu Pro 
    2000                 2005                 2010             


Ser Xaa  Gln Leu Asp Pro Gly  Gly Ala Leu Met Ala  His Glu Ser 
    2015                 2020                 2025             


Gly Leu  Lys Glu Ser Pro Ser  Trp Val Xaa Gln Arg  Ala Gln Glu 
    2030                 2035                 2040             


Met Phe  Gln Lys Xaa Gly Xaa  Trp Ser Pro Glu Gln  Gly Pro Pro 
    2045                 2050                 2055             


Xaa Asp  Met Pro Asn Ser Gln  Pro Asn Ser Gln Ser  Val Glu Met 
    2060                 2065                 2070             


Arg Glu  Met Gly Arg Asp Gly  Tyr Ser Asp Ser Glu  His Tyr Leu 
    2075                 2080                 2085             


Pro Met  Glu Gly Gln Gly Arg  Ala Ala Ser Met Pro  Arg Leu Pro 
    2090                 2095                 2100             


Ala Glu  Asn Gln Arg Arg Arg  Gly Arg Pro Arg Gly  Asn Asn Leu 
    2105                 2110                 2115             


Ser Xaa  Ile Ser Asp Xaa Ser  Pro Met Lys Arg Ser  Ala Ser Val 
    2120                 2125                 2130             


Leu Gly  Pro Lys Ala Arg Arg  Leu Asp Asp Tyr Ser  Leu Glu Arg 
    2135                 2140                 2145             


Val Pro  Pro Glu Glu Asn Gln  Arg His His Gln Arg  Arg Arg Asp 
    2150                 2155                 2160             


Arg Ser  His Arg Ala Ser Glu  Arg Ser Leu Gly Arg  Tyr Xaa Asp 
    2165                 2170                 2175             


Val Asp  Xaa Gly Leu Gly Xaa  Asp Leu Ser Met Xaa  Xaa Gln Ser 
    2180                 2185                 2190             


Gly Asp  Leu Pro Ser Lys Glu  Arg Asp Gln Glu Arg  Gly Arg Pro 
    2195                 2200                 2205             


Lys Asp  Arg Lys His Arg Gln  His His His His His  His His His 
    2210                 2215                 2220             


His His  Pro Pro Pro Pro Asp  Lys Asp Arg Tyr Ala  Gln Glu Arg 
    2225                 2230                 2235             


Pro Asp  His Gly Arg Ala Arg  Ala Arg Asp Gln Arg  Trp Ser Arg 
    2240                 2245                 2250             


Ser Pro  Ser Glu Gly Arg Glu  His Met Ala His Arg  Gln Gly Ser 
    2255                 2260                 2265             


Ser Ser  Val Ser Gly Ser Pro  Ala Pro Ser Xaa Ser  Gly Xaa Ser 
    2270                 2275                 2280             


Xaa Pro  Arg Arg Gly Arg Arg  Gln Leu Pro Gln Xaa  Pro Ser Xaa 
    2285                 2290                 2295             


Pro Arg  Pro His Val Ser Tyr  Ser Pro Val Ile Arg  Lys Ala Gly 
    2300                 2305                 2310             


Gly Ser  Gly Pro Pro Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2315                 2320                 2325             


Gln Gln  Gln Ala Val Ala Arg  Pro Gly Arg Ala Ala  Xaa Ser Gly 
    2330                 2335                 2340             


Pro Arg  Arg Tyr Pro Gly Pro  Xaa Ala Glu Pro Leu  Ala Gly Asp 
    2345                 2350                 2355             


Arg Pro  Pro Xaa Gly Gly His  Ser Ser Gly Arg Ser  Pro Arg Met 
    2360                 2365                 2370             


Glu Arg  Arg Val Pro Gly Pro  Ala Arg Ser Glu Ser  Pro Arg Ala 
    2375                 2380                 2385             


Cys Arg  His Gly Gly Ala Arg  Trp Pro Ala Ser Gly  Pro His Val 
    2390                 2395                 2400             


Ser Glu  Gly Pro Pro Gly Pro  Arg His His Gly Tyr  Tyr Arg Gly 
    2405                 2410                 2415             


Ser Asp  Tyr Asp Glu Ala Asp  Gly Pro Gly Ser Gly  Gly Gly Glu 
    2420                 2425                 2430             


Glu Ala  Met Ala Gly Ala Tyr  Asp Ala Pro Pro Pro  Val Arg His 
    2435                 2440                 2445             


Ala Ser  Ser Gly Ala Xaa Gly  Arg Ser Pro Arg Xaa  Pro Arg Ala 
    2450                 2455                 2460             


Ser Gly  Pro Ala Cys Ala Ser  Pro Ser Arg His Gly  Arg Arg Leu 
    2465                 2470                 2475             


Pro Asn  Gly Tyr Tyr Pro Ala  His Gly Leu Ala Arg  Pro Arg Gly 
    2480                 2485                 2490             


Pro Gly  Ser Arg Lys Gly Leu  His Glu Pro Tyr Ser  Glu Ser Asp 
    2495                 2500                 2505             


Asp Asp  Trp Cys 
    2510         


<210> 4640
<211> 35
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<400> 4640
Met Ser Ser Trp Pro Xaa Arg Pro Xaa Lys Ser Xaa Ala Pro Pro Arg 
1               5                   10                  15      


Pro Gly Gly Lys Asn Gly Arg Ser Tyr Gln Arg Met Cys Phe Xaa Gln 
            20                  25                  30          


Xaa Arg Glu 
        35  


<210> 4641
<211> 103
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<400> 4641
Met Ser Ser Trp Pro Xaa Arg Pro Xaa Lys Ser Xaa Ala Pro Pro Arg 
1               5                   10                  15      


Pro Gly Gly Lys Asn Gly Xaa Xaa Ile Ile Ala Asn Cys Ile Val Leu 
            20                  25                  30          


Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Xaa Pro Met Ser Glu 
        35                  40                  45              


Arg Leu Asp Asp Xaa Glu Pro Tyr Phe Ile Gly Ile Phe Cys Phe Glu 
    50                  55                  60                  


Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His Lys Gly Ser 
65                  70                  75                  80  


Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val Val Leu Xaa 
                85                  90                  95      


Gly Ile Leu Ala Xaa Val Gly 
            100             


<210> 4642
<211> 981
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<400> 4642
Gln Glu Gln Gly Asp Lys Met Met Glu Glu Tyr Ser Leu Glu Lys Asn 
1               5                   10                  15      


Glu Arg Ala Cys Ile Asp Phe Ala Ile Ser Ala Lys Pro Leu Xaa Arg 
            20                  25                  30          


His Met Pro Gln Asn Lys Gln Ser Phe Gln Tyr Arg Met Trp Gln Phe 
        35                  40                  45              


Val Val Ser Pro Pro Phe Glu Tyr Xaa Ile Met Ala Met Ile Ala Leu 
    50                  55                  60                  


Asn Xaa Ile Val Leu Met Met Lys Phe Tyr Gly Ala Ser Val Ala Tyr 
65                  70                  75                  80  


Glu Asn Ala Leu Arg Val Phe Asn Ile Val Phe Xaa Ser Leu Phe Ser 
                85                  90                  95      


Leu Glu Cys Val Leu Lys Val Met Ala Phe Gly Ile Leu Asn Tyr Phe 
            100                 105                 110         


Arg Asp Ala Trp Asn Ile Phe Asp Phe Val Xaa Val Leu Gly Ser Ile 
        115                 120                 125             


Xaa Asp Ile Leu Val Xaa Glu Phe Gly Asn Asn Phe Ile Asn Leu Ser 
    130                 135                 140                 


Phe Leu Arg Leu Phe Arg Ala Ala Arg Leu Ile Lys Leu Leu Arg Gln 
145                 150                 155                 160 


Gly Tyr Xaa Ile Arg Ile Leu Leu Trp Xaa Phe Val Gln Ser Phe Lys 
                165                 170                 175     


Ala Leu Pro Tyr Val Cys Leu Leu Ile Ala Met Leu Phe Phe Ile Tyr 
            180                 185                 190         


Ala Ile Ile Gly Met Gln Val Phe Gly Asn Ile Gly Ile Asp Val Glu 
        195                 200                 205             


Asp Glu Asp Ser Asp Glu Asp Glu Phe Gln Ile Xaa Glu His Asn Asn 
    210                 215                 220                 


Phe Arg Xaa Phe Phe Gln Ala Leu Met Leu Leu Phe Arg Ser Ala Xaa 
225                 230                 235                 240 


Gly Glu Ala Trp His Asn Ile Met Leu Ser Cys Leu Ser Gly Lys Pro 
                245                 250                 255     


Cys Asp Lys Asn Ser Gly Ile Leu Xaa Arg Glu Cys Gly Asn Glu Phe 
            260                 265                 270         


Ala Tyr Phe Tyr Phe Val Ser Phe Ile Phe Leu Cys Ser Phe Leu Met 
        275                 280                 285             


Leu Asn Leu Phe Val Ala Val Ile Met Asp Asn Phe Glu Tyr Leu Xaa 
    290                 295                 300                 


Arg Asp Ser Ser Ile Leu Gly Pro His His Leu Asp Glu Tyr Val Arg 
305                 310                 315                 320 


Val Trp Ala Glu Tyr Asp Pro Ala Ala Cys Gly Arg Ile His Tyr Lys 
                325                 330                 335     


Asp Met Tyr Ser Leu Leu Arg Val Ile Ser Pro Pro Leu Gly Leu Gly 
            340                 345                 350         


Lys Lys Cys Pro His Arg Val Ala Cys Lys Arg Leu Leu Arg Met Asp 
        355                 360                 365             


Leu Pro Val Ala Asp Asp Asn Xaa Val His Phe Asn Ser Xaa Leu Met 
    370                 375                 380                 


Ala Leu Ile Arg Xaa Ala Leu Asp Ile Lys Ile Ala Lys Gly Gly Ala 
385                 390                 395                 400 


Asp Lys Gln Gln Met Asp Ala Glu Leu Arg Lys Glu Met Met Ala Ile 
                405                 410                 415     


Trp Pro Asn Leu Ser Gln Lys Xaa Leu Asp Leu Leu Val Xaa Pro His 
            420                 425                 430         


Lys Ser Xaa Asp Leu Xaa Val Gly Lys Ile Tyr Ala Ala Met Met Ile 
        435                 440                 445             


Met Glu Tyr Tyr Arg Gln Ser Lys Ala Lys Lys Leu Gln Ala Met Arg 
    450                 455                 460                 


Glu Glu Gln Asp Arg Xaa Pro Leu Met Phe Gln Arg Met Glu Pro Pro 
465                 470                 475                 480 


Ser Pro Xaa Gln Glu Gly Gly Pro Gly Gln Asn Ala Leu Pro Ser Xaa 
                485                 490                 495     


Gln Leu Asp Pro Gly Gly Ala Leu Met Ala His Glu Ser Gly Leu Lys 
            500                 505                 510         


Glu Ser Pro Ser Trp Val Xaa Gln Arg Ala Gln Glu Met Phe Gln Lys 
        515                 520                 525             


Xaa Gly Xaa Trp Ser Pro Glu Gln Gly Pro Pro Xaa Asp Met Pro Asn 
    530                 535                 540                 


Ser Gln Pro Asn Ser Gln Ser Val Glu Met Arg Glu Met Gly Arg Asp 
545                 550                 555                 560 


Gly Tyr Ser Asp Ser Glu His Tyr Leu Pro Met Glu Gly Gln Gly Arg 
                565                 570                 575     


Ala Ala Ser Met Pro Arg Leu Pro Ala Glu Asn Gln Xaa Ile Ser Asp 
            580                 585                 590         


Xaa Ser Pro Met Lys Arg Ser Ala Ser Val Leu Gly Pro Lys Ala Arg 
        595                 600                 605             


Arg Leu Asp Asp Tyr Ser Leu Glu Arg Val Pro Pro Glu Glu Asn Gln 
    610                 615                 620                 


Arg His His Gln Arg Arg Arg Asp Arg Ser His Arg Ala Ser Glu Arg 
625                 630                 635                 640 


Ser Leu Gly Arg Tyr Xaa Asp Val Asp Xaa Gly Leu Gly Xaa Asp Leu 
                645                 650                 655     


Ser Met Xaa Xaa Gln Ser Gly Asp Leu Pro Ser Lys Glu Arg Asp Gln 
            660                 665                 670         


Glu Arg Gly Arg Pro Lys Asp Arg Lys His Arg Gln His His His His 
        675                 680                 685             


His His His His His His Pro Pro Pro Pro Asp Lys Asp Arg Tyr Ala 
    690                 695                 700                 


Gln Glu Arg Pro Asp His Gly Arg Ala Arg Ala Arg Asp Gln Arg Trp 
705                 710                 715                 720 


Ser Arg Ser Pro Ser Glu Gly Arg Glu His Met Ala His Arg Gln Gly 
                725                 730                 735     


Ser Ser Ser Val Ser Gly Ser Pro Ala Pro Ser Xaa Ser Gly Xaa Ser 
            740                 745                 750         


Xaa Pro Arg Arg Gly Arg Arg Gln Leu Pro Gln Xaa Pro Ser Xaa Pro 
        755                 760                 765             


Arg Pro His Val Ser Tyr Ser Pro Val Ile Arg Lys Ala Gly Gly Ser 
    770                 775                 780                 


Gly Pro Pro Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
785                 790                 795                 800 


Ala Val Ala Arg Pro Gly Arg Ala Ala Xaa Ser Gly Pro Arg Arg Tyr 
                805                 810                 815     


Pro Gly Pro Xaa Ala Glu Pro Leu Ala Gly Asp Arg Pro Pro Xaa Gly 
            820                 825                 830         


Gly His Ser Ser Gly Arg Ser Pro Arg Met Glu Arg Arg Val Pro Gly 
        835                 840                 845             


Pro Ala Arg Ser Glu Ser Pro Arg Ala Cys Arg His Gly Gly Ala Arg 
    850                 855                 860                 


Trp Pro Ala Ser Gly Pro His Val Ser Glu Gly Pro Pro Gly Pro Arg 
865                 870                 875                 880 


His His Gly Tyr Tyr Arg Gly Ser Asp Tyr Asp Glu Ala Asp Gly Pro 
                885                 890                 895     


Gly Ser Gly Gly Gly Glu Glu Ala Met Ala Gly Ala Tyr Asp Ala Pro 
            900                 905                 910         


Pro Pro Val Arg His Ala Ser Ser Gly Ala Xaa Gly Arg Ser Pro Arg 
        915                 920                 925             


Xaa Pro Arg Ala Ser Gly Pro Ala Cys Ala Ser Pro Ser Arg His Gly 
    930                 935                 940                 


Arg Arg Leu Pro Asn Gly Tyr Tyr Pro Ala His Gly Leu Ala Arg Pro 
945                 950                 955                 960 


Arg Gly Pro Gly Ser Arg Lys Gly Leu His Glu Pro Tyr Ser Glu Ser 
                965                 970                 975     


Asp Asp Asp Trp Cys 
            980     


<210> 4643
<211> 75
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<400> 4643
Ser Phe Ile Phe Leu Cys Ser Phe Leu Met Leu Asn Leu Phe Val Ala 
1               5                   10                  15      


Val Ile Met Asp Asn Phe Glu Tyr Leu Xaa Arg Asp Ser Ser Ile Leu 
            20                  25                  30          


Gly Pro His His Leu Asp Glu Tyr Val Arg Val Trp Ala Glu Tyr Asp 
        35                  40                  45              


Pro Ala Ala Cys Gly Phe Cys Gly Trp Xaa Cys Pro Ser Gln Met Xaa 
    50                  55                  60                  


Xaa Pro Ser Xaa Ser Ile Pro Pro Ser Trp Leu 
65                  70                  75  


<210> 4644
<211> 881
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<400> 4644
Val Met Ala Phe Gly Ile Leu Asn Tyr Phe Arg Asp Ala Trp Asn Ile 
1               5                   10                  15      


Phe Asp Phe Val Xaa Val Leu Gly Ser Ile Xaa Asp Ile Leu Val Xaa 
            20                  25                  30          


Glu Phe Gly Asn Pro Asn Asn Phe Ile Asn Leu Ser Phe Leu Arg Leu 
        35                  40                  45              


Phe Arg Ala Ala Arg Leu Ile Lys Leu Leu Arg Gln Gly Tyr Xaa Ile 
    50                  55                  60                  


Arg Ile Leu Leu Trp Xaa Phe Val Gln Ser Phe Lys Ala Leu Pro Tyr 
65                  70                  75                  80  


Val Cys Leu Leu Ile Ala Met Leu Phe Phe Ile Tyr Ala Ile Ile Gly 
                85                  90                  95      


Met Gln Val Phe Gly Asn Ile Gly Ile Asp Val Glu Asp Glu Asp Ser 
            100                 105                 110         


Asp Glu Asp Glu Phe Gln Ile Xaa Glu His Asn Asn Phe Arg Xaa Phe 
        115                 120                 125             


Phe Gln Ala Leu Met Leu Leu Phe Arg Ser Ala Xaa Gly Glu Ala Trp 
    130                 135                 140                 


His Asn Ile Met Leu Ser Cys Leu Ser Gly Lys Pro Cys Asp Lys Asn 
145                 150                 155                 160 


Ser Gly Ile Leu Xaa Arg Glu Cys Gly Asn Glu Phe Ala Tyr Phe Tyr 
                165                 170                 175     


Phe Val Ser Phe Ile Phe Leu Cys Ser Phe Leu Met Leu Asn Leu Phe 
            180                 185                 190         


Val Ala Val Ile Met Asp Asn Phe Glu Tyr Leu Xaa Arg Asp Ser Ser 
        195                 200                 205             


Ile Leu Gly Pro His His Leu Asp Glu Tyr Val Arg Val Trp Ala Glu 
    210                 215                 220                 


Tyr Asp Pro Ala Ala Trp Gly Arg Met Pro Tyr Leu Asp Met Tyr Gln 
225                 230                 235                 240 


Met Leu Arg His Met Ser Pro Pro Leu Gly Leu Gly Lys Lys Cys Pro 
                245                 250                 255     


Ala Arg Val Ala Tyr Lys Arg Leu Leu Arg Met Asp Leu Pro Val Ala 
            260                 265                 270         


Asp Asp Asn Xaa Val His Phe Asn Ser Xaa Leu Met Ala Leu Ile Arg 
        275                 280                 285             


Xaa Ala Leu Asp Ile Lys Ile Ala Lys Gly Gly Ala Asp Lys Gln Gln 
    290                 295                 300                 


Met Asp Ala Glu Leu Arg Lys Glu Met Met Ala Ile Trp Pro Asn Leu 
305                 310                 315                 320 


Ser Gln Lys Xaa Leu Asp Leu Leu Val Xaa Pro His Lys Ser Xaa Asp 
                325                 330                 335     


Leu Xaa Val Gly Lys Ile Tyr Ala Ala Met Met Ile Met Glu Tyr Tyr 
            340                 345                 350         


Arg Gln Ser Lys Ala Lys Lys Leu Gln Ala Met Arg Glu Glu Gln Asp 
        355                 360                 365             


Arg Xaa Pro Leu Met Phe Gln Arg Met Glu Pro Pro Ser Pro Xaa Gln 
    370                 375                 380                 


Glu Gly Gly Pro Gly Gln Asn Ala Leu Pro Ser Xaa Gln Leu Asp Pro 
385                 390                 395                 400 


Gly Gly Ala Leu Met Ala His Glu Ser Gly Leu Lys Glu Ser Pro Ser 
                405                 410                 415     


Trp Val Xaa Gln Arg Ala Gln Glu Met Phe Gln Lys Xaa Gly Xaa Trp 
            420                 425                 430         


Ser Pro Glu Gln Gly Pro Pro Xaa Asp Met Pro Asn Ser Gln Pro Asn 
        435                 440                 445             


Ser Gln Ser Val Glu Met Arg Glu Met Gly Arg Asp Gly Tyr Ser Asp 
    450                 455                 460                 


Ser Glu His Tyr Leu Pro Met Glu Gly Gln Gly Arg Ala Ala Ser Met 
465                 470                 475                 480 


Pro Arg Leu Pro Ala Glu Asn Gln Xaa Ile Ser Asp Xaa Ser Pro Met 
                485                 490                 495     


Lys Arg Ser Ala Ser Val Leu Gly Pro Lys Ala Arg Arg Leu Asp Asp 
            500                 505                 510         


Tyr Ser Leu Glu Arg Val Pro Pro Glu Glu Asn Gln Arg His His Gln 
        515                 520                 525             


Arg Arg Arg Asp Arg Ser His Arg Ala Ser Glu Arg Ser Leu Gly Arg 
    530                 535                 540                 


Tyr Xaa Asp Val Asp Xaa Gly Leu Gly Xaa Asp Leu Ser Met Xaa Xaa 
545                 550                 555                 560 


Gln Ser Gly Asp Leu Pro Ser Lys Glu Arg Asp Gln Glu Arg Gly Arg 
                565                 570                 575     


Pro Lys Asp Arg Lys His Arg Gln His His His His His His His His 
            580                 585                 590         


His His Pro Pro Pro Pro Asp Lys Asp Arg Tyr Ala Gln Glu Arg Pro 
        595                 600                 605             


Asp His Gly Arg Ala Arg Ala Arg Asp Gln Arg Trp Ser Arg Ser Pro 
    610                 615                 620                 


Ser Glu Gly Arg Glu His Met Ala His Arg Gln Gly Ser Ser Ser Val 
625                 630                 635                 640 


Ser Gly Ser Pro Ala Pro Ser Xaa Ser Gly Xaa Ser Xaa Pro Arg Arg 
                645                 650                 655     


Gly Arg Arg Gln Leu Pro Gln Xaa Pro Ser Xaa Pro Arg Pro His Val 
            660                 665                 670         


Ser Tyr Ser Pro Val Ile Arg Lys Ala Gly Gly Ser Gly Pro Pro Gln 
        675                 680                 685             


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Val Ala Arg 
    690                 695                 700                 


Pro Gly Arg Ala Ala Xaa Ser Gly Pro Arg Arg Tyr Pro Gly Pro Xaa 
705                 710                 715                 720 


Ala Glu Pro Leu Ala Gly Asp Arg Pro Pro Xaa Gly Gly His Ser Ser 
                725                 730                 735     


Gly Arg Ser Pro Arg Met Glu Arg Arg Val Pro Gly Pro Ala Arg Ser 
            740                 745                 750         


Glu Ser Pro Arg Ala Cys Arg His Gly Gly Ala Arg Trp Pro Ala Ser 
        755                 760                 765             


Gly Pro His Val Ser Glu Gly Pro Pro Gly Pro Arg His His Gly Tyr 
    770                 775                 780                 


Tyr Arg Gly Ser Asp Tyr Asp Glu Ala Asp Gly Pro Gly Ser Gly Gly 
785                 790                 795                 800 


Gly Glu Glu Ala Met Ala Gly Ala Tyr Asp Ala Pro Pro Pro Val Arg 
                805                 810                 815     


His Ala Ser Ser Gly Ala Xaa Gly Arg Ser Pro Arg Xaa Pro Arg Ala 
            820                 825                 830         


Ser Gly Pro Ala Cys Ala Ser Pro Ser Arg His Gly Arg Arg Leu Pro 
        835                 840                 845             


Asn Gly Tyr Tyr Pro Ala His Gly Leu Ala Arg Pro Arg Gly Pro Gly 
    850                 855                 860                 


Ser Arg Lys Gly Leu His Glu Pro Tyr Ser Glu Ser Asp Asp Asp Trp 
865                 870                 875                 880 


Cys 
    


<210> 4645
<211> 550
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(475)
<223> Selenocysteine

<400> 4645
Val Met Ala Phe Gly Ile Leu Asn Tyr Phe Arg Asp Ala Trp Asn Ile 
1               5                   10                  15      


Phe Asp Phe Val Xaa Val Leu Gly Ser Ile Xaa Asp Ile Leu Val Xaa 
            20                  25                  30          


Glu Phe Gly Asn Pro Asn Asn Phe Ile Asn Leu Ser Phe Leu Arg Leu 
        35                  40                  45              


Phe Arg Ala Ala Arg Leu Ile Lys Leu Leu Arg Gln Gly Tyr Xaa Ile 
    50                  55                  60                  


Arg Ile Leu Leu Trp Xaa Phe Val Gln Ser Phe Lys Val Phe Gly Asn 
65                  70                  75                  80  


Ile Gly Ile Asp Val Glu Asp Glu Asp Ser Asp Glu Asp Glu Phe Gln 
                85                  90                  95      


Ile Xaa Glu His Asn Asn Phe Arg Xaa Phe Phe Gln Ala Leu Met Leu 
            100                 105                 110         


Leu Phe Arg Ser Ala Xaa Gly Glu Ala Trp His Asn Ile Met Leu Ser 
        115                 120                 125             


Cys Leu Ser Gly Lys Pro Cys Asp Lys Asn Ser Gly Ile Leu Xaa Arg 
    130                 135                 140                 


Glu Cys Gly Asn Glu Phe Ala Tyr Phe Tyr Phe Val Ser Phe Ile Phe 
145                 150                 155                 160 


Leu Cys Ser Phe Leu Arg Leu Leu Arg Met Asp Leu Pro Val Ala Asp 
                165                 170                 175     


Asp Asn Xaa Val His Phe Asn Ser Xaa Leu Met Ala Leu Ile Arg Xaa 
            180                 185                 190         


Ala Leu Asp Ile Lys Ile Ala Lys Gly Gly Ala Asp Lys Gln Gln Met 
        195                 200                 205             


Asp Ala Glu Leu Arg Lys Glu Met Met Ala Ile Trp Pro Asn Leu Ser 
    210                 215                 220                 


Gln Lys Xaa Leu Asp Leu Leu Val Xaa Pro His Lys Ser Xaa Asp Leu 
225                 230                 235                 240 


Xaa Val Gly Lys Ile Tyr Ala Ala Met Met Ile Met Glu Tyr Tyr Arg 
                245                 250                 255     


Gln Ser Lys Ala Lys Lys Leu Gln Ala Met Arg Glu Glu Gln Asp Arg 
            260                 265                 270         


Xaa Pro Leu Met Phe Gln Arg Met Glu Pro Pro Ser Pro Xaa Gln Glu 
        275                 280                 285             


Gly Gly Pro Gly Gln Asn Ala Leu Pro Ser Xaa Gln Leu Asp Pro Gly 
    290                 295                 300                 


Gly Ala Leu Met Ala His Glu Ser Gly Leu Lys Glu Ser Pro Ser Trp 
305                 310                 315                 320 


Val Xaa Gln Arg Ala Gln Glu Met Phe Gln Lys Xaa Gly Xaa Trp Ser 
                325                 330                 335     


Pro Glu Gln Gly Pro Pro Xaa Asp Met Pro Asn Ser Gln Pro Asn Ser 
            340                 345                 350         


Gln Ser Val Glu Met Arg Glu Met Gly Arg Asp Gly Tyr Ser Asp Ser 
        355                 360                 365             


Glu His Tyr Leu Pro Met Glu Gly Gln Gly Arg Ala Ala Ser Met Pro 
    370                 375                 380                 


Arg Leu Pro Ala Glu Asn Gln Arg Arg Arg Gly Arg Pro Arg Gly Asn 
385                 390                 395                 400 


Asn Leu Ser Xaa Ile Ser Asp Xaa Ser Pro Met Lys Arg Ser Ala Ser 
                405                 410                 415     


Val Leu Gly Pro Lys Ala Arg Arg Leu Asp Asp Tyr Ser Leu Glu Arg 
            420                 425                 430         


Val Pro Pro Glu Glu Asn Gln Arg His His Gln Arg Arg Arg Asp Arg 
        435                 440                 445             


Ser His Arg Ala Ser Glu Arg Ser Leu Gly Arg Tyr Xaa Asp Val Asp 
    450                 455                 460                 


Xaa Gly Leu Gly Xaa Asp Leu Ser Met Xaa Xaa Gln Ser Gly Asp Leu 
465                 470                 475                 480 


Pro Ser Lys Glu Arg Asp Gln Glu Arg Gly Arg Pro Lys Asp Arg Lys 
                485                 490                 495     


His Arg Gln His His His His His His His His His His Pro Pro Pro 
            500                 505                 510         


Pro Asp Lys Asp Arg Tyr Ala Gln Glu Arg Pro Asp His Gly Arg Ala 
        515                 520                 525             


Arg Ala Arg Asp Gln Arg Trp Ser Arg Ser Pro Ser Glu Gly Arg Glu 
    530                 535                 540                 


His Met Ala His Arg Gln 
545                 550 


<210> 4646
<211> 79
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<400> 4646
Xaa Lys Phe Tyr Gly Ala Ser Val Ala Tyr Glu Asn Ala Leu Arg Val 
1               5                   10                  15      


Phe Asn Ile Val Phe Xaa Ser Leu Phe Ser Leu Glu Cys Val Leu Lys 
            20                  25                  30          


Val Met Ala Phe Gly Ile Leu Asn Tyr Phe Arg Asp Ala Trp Asn Ile 
        35                  40                  45              


Phe Asp Phe Val Xaa Val Leu Gly Ser Ile Xaa Asp Ile Leu Val Xaa 
    50                  55                  60                  


Glu Phe Gly Ala Trp Ser Arg Ala Xaa Pro Pro Ser Pro Arg Ser 
65                  70                  75                  


<210> 4647
<211> 44
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<400> 4647
Xaa Leu Asn Tyr Phe Arg Asp Ala Trp Asn Ile Phe Asp Phe Val Xaa 
1               5                   10                  15      


Val Leu Gly Ser Ile Xaa Asp Ile Leu Val Xaa Glu Phe Gly Asn Pro 
            20                  25                  30          


Ala Trp Ser Arg Ala Xaa Pro Pro Ser Pro Arg Ser 
        35                  40                  


<210> 4648
<211> 26
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<400> 4648
Xaa Ser Ile Xaa Asp Ile Leu Val Xaa Glu Phe Gly Asn Pro Ala Trp 
1               5                   10                  15      


Ser Arg Ala Xaa Pro Pro Ser Pro Arg Ser 
            20                  25      


<210> 4649
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<400> 4649
Met Ala Tyr Val Cys Lys Leu Leu Met Ser Lys Xaa Arg Pro Leu Val 
1               5                   10                  15      


Met Ile Gly Val Ala Trp Val Met Leu Leu Tyr Arg Ser Ile Asp Ser 
            20                  25                  30          


His Xaa Glu Asp Lys Gly Pro Ile Tyr Asn Tyr Arg Val Glu Ile Ser 
        35                  40                  45              


Ile Phe Phe Ile Ile Tyr Ile Ile Ile Ile Ala Phe Phe Met Met Asn 
    50                  55                  60                  


Ile Phe Val Gly Phe Val Ile Val Xaa Phe Gln Glu Gln Gly Glu Gln 
65                  70                  75                  80  


Glu Tyr Lys Asn Cys Glu Leu Asp Lys Asn Gln Arg Gln Cys Val Glu 
                85                  90                  95      


Tyr Ala Leu Lys Ala Arg Pro Leu Arg Arg Tyr Ile Pro Lys Asn Gln 
            100                 105                 110         


His Gln Tyr Lys Val Trp Tyr Val Val Asn Ser Xaa Tyr Phe Glu Tyr 
        115                 120                 125             


Leu Met Phe Val Leu Ile Leu Leu Asn Xaa Ile Cys Leu Ala Met Gln 
    130                 135                 140                 


<210> 4650
<211> 829
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<400> 4650
Met Phe Ile Val Ser Gln Asn Ala Glu Glu Asn Ser Arg Ile Ser Ile 
1               5                   10                  15      


Xaa Phe Phe Arg Leu Phe Arg Val Met Arg Leu Val Lys Leu Leu Ser 
            20                  25                  30          


Arg Gly Glu Gly Ile Arg Xaa Leu Leu Trp Xaa Phe Ile Lys Ser Phe 
        35                  40                  45              


Gln Ala Leu Pro Tyr Val Ala Leu Leu Ile Val Met Leu Phe Phe Ile 
    50                  55                  60                  


Tyr Ala Val Ile Gly Met Gln Val Phe Gly Lys Ile Ala Leu Asn Asp 
65                  70                  75                  80  


Xaa Xaa Glu Ile Asn Arg Asn Asn Asn Phe Gln Xaa Phe Pro Gln Ala 
                85                  90                  95      


Val Leu Leu Leu Phe Arg Cys Ala Xaa Gly Glu Ala Trp Gln Asp Ile 
            100                 105                 110         


Met Leu Ala Cys Met Pro Gly Lys Lys Cys Ala Pro Glu Ser Glu Pro 
        115                 120                 125             


Ser Asn Ser Xaa Glu Gly Glu Xaa Pro Cys Gly Ser Ser Phe Ala Val 
    130                 135                 140                 


Phe Tyr Phe Ile Ser Phe Tyr Met Leu Cys Ala Phe Leu Ile Ile Asn 
145                 150                 155                 160 


Leu Phe Val Ala Val Ile Met Asp Asn Phe Asp Tyr Leu Xaa Arg Asp 
                165                 170                 175     


Trp Ser Ile Leu Gly Pro His His Leu Asp Glu Phe Lys Arg Ile Trp 
            180                 185                 190         


Ala Glu Tyr Asp Pro Glu Ala Lys Gly Arg Ile Lys His Leu Asp Val 
        195                 200                 205             


Val Xaa Leu Leu Arg Arg Ile Gln Pro Pro Leu Gly Phe Gly Lys Leu 
    210                 215                 220                 


Cys Pro His Arg Val Ala Cys Lys Arg Leu Val Ser Met Asn Met Pro 
225                 230                 235                 240 


Leu Asn Ser Asp Gly Xaa Val Met Phe Asn Ala Xaa Leu Phe Ala Leu 
                245                 250                 255     


Val Arg Xaa Ala Leu Arg Ile Lys Xaa Glu Gly Asn Leu Glu Gln Ala 
            260                 265                 270         


Asn Glu Glu Leu Arg Ala Ile Ile Lys Lys Ile Trp Lys Arg Xaa Ser 
        275                 280                 285             


Met Lys Leu Leu Asp Gln Val Val Pro Pro Ala Gly Asp Asp Glu Val 
    290                 295                 300                 


Xaa Val Gly Lys Phe Tyr Ala Xaa Phe Leu Ile Gln Glu Tyr Phe Arg 
305                 310                 315                 320 


Lys Phe Lys Lys Arg Lys Glu Gln Gly Leu Val Gly Lys Pro Ser Gln 
                325                 330                 335     


Arg Asn Ala Leu Ser Leu Gln Ala Gly Leu Arg Xaa Leu His Asp Ile 
            340                 345                 350         


Gly Pro Glu Ile Arg Arg Ala Ile Ser Gly Asp Leu Xaa Ala Glu Glu 
        355                 360                 365             


Glu Leu Asp Lys Ala Met Lys Glu Ala Val Ser Ala Ala Ser Glu Asp 
    370                 375                 380                 


Asp Ile Phe Arg Arg Ala Gly Gly Leu Phe Gly Asn His Val Ser Tyr 
385                 390                 395                 400 


Tyr Gln Ser Asp Gly Arg Ser Ala Phe Pro Gln Xaa Phe Xaa Xaa Gln 
                405                 410                 415     


Arg Pro Leu His Ile Asn Lys Ala Gly Ser Ser Gln Gly Asp Xaa Glu 
            420                 425                 430         


Ser Pro Ser His Glu Lys Leu Val Asp Ser Xaa Phe Xaa Pro Ser Ser 
        435                 440                 445             


Tyr Ser Ser Xaa Gly Ser Asn Ala Asn Ile Asn Asn Ala Asn Asn Xaa 
    450                 455                 460                 


Ala Leu Gly Arg Leu Pro Arg Pro Ala Gly Tyr Pro Ser Xaa Val Ser 
465                 470                 475                 480 


Xaa Val Glu Gly His Gly Pro Pro Leu Ser Pro Ala Ile Arg Val Gln 
                485                 490                 495     


Glu Val Ala Trp Lys Leu Ser Ser Asn Arg Cys His Ser Arg Glu Ser 
            500                 505                 510         


Gln Ala Ala Met Ala Gly Gln Glu Glu Xaa Ser Gln Asp Glu Xaa Tyr 
        515                 520                 525             


Glu Val Lys Met Asn His Asp Xaa Glu Ala Cys Ser Glu Pro Ser Leu 
    530                 535                 540                 


Leu Ser Xaa Glu Met Leu Ser Tyr Gln Asp Asp Glu Asn Arg Gln Leu 
545                 550                 555                 560 


Xaa Leu Pro Glu Glu Asp Lys Arg Asp Ile Arg Gln Ser Pro Lys Arg 
                565                 570                 575     


Gly Phe Leu Arg Ser Ala Ser Leu Gly Arg Arg Ala Ser Phe His Leu 
            580                 585                 590         


Glu Cys Leu Lys Arg Gln Lys Asp Arg Gly Gly Asp Ile Ser Gln Lys 
        595                 600                 605             


Xaa Val Leu Pro Leu His Leu Val His His Gln Ala Leu Ala Val Ala 
    610                 615                 620                 


Gly Leu Ser Pro Leu Leu Gln Arg Ser His Ser Pro Ala Ser Phe Pro 
625                 630                 635                 640 


Arg Pro Phe Ala Xaa Pro Pro Ala Xaa Pro Gly Ser Arg Gly Trp Pro 
                645                 650                 655     


Pro Gln Pro Val Pro Xaa Leu Arg Leu Glu Gly Val Glu Ser Ser Glu 
            660                 665                 670         


Lys Leu Asn Ser Ser Phe Pro Ser Ile His Cys Gly Ser Trp Ala Glu 
        675                 680                 685             


Xaa Xaa Pro Gly Gly Gly Gly Ser Ser Ala Ala Arg Arg Val Arg Pro 
    690                 695                 700                 


Val Ser Leu Met Val Pro Ser Gln Ala Gly Ala Pro Gly Arg Gln Phe 
705                 710                 715                 720 


His Gly Ser Ala Ser Ser Leu Val Glu Ala Val Leu Ile Ser Glu Gly 
                725                 730                 735     


Leu Gly Gln Phe Ala Gln Asp Pro Lys Phe Ile Glu Val Xaa Xaa Gln 
            740                 745                 750         


Glu Leu Ala Asp Ala Cys Asp Met Xaa Ile Glu Glu Met Glu Ser Ala 
        755                 760                 765             


Ala Asp Asn Ile Leu Ser Gly Gly Ala Pro Gln Ser Pro Asn Gly Ala 
    770                 775                 780                 


Leu Leu Pro Phe Val Asn Cys Arg Asp Ala Gly Gln Asp Arg Ala Gly 
785                 790                 795                 800 


Gly Glu Glu Asp Ala Gly Cys Val Arg Ala Arg Gly Arg Pro Ser Glu 
                805                 810                 815     


Glu Glu Leu Gln Asp Ser Arg Val Tyr Val Ser Ser Leu 
            820                 825                 


<210> 4651
<211> 100
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<400> 4651
Met Leu Arg Ala Phe Val Gln Pro Gly Xaa Pro Ala Tyr Gln Pro Leu 
1               5                   10                  15      


Pro Ser His Leu Ser Ala Asn Xaa Glu Val Lys Phe Lys Gly Xaa Leu 
            20                  25                  30          


Val His Glu Ala Gln Leu Asn Tyr Phe Tyr Ile Ser Pro Gly Gly Ser 
        35                  40                  45              


Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala Asn Ala 
    50                  55                  60                  


Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala Ala Leu 
65                  70                  75                  80  


Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu Met Gly 
                85                  90                  95      


Ser Ala Gly Asn 
            100 


<210> 4652
<211> 1279
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<400> 4652
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Xaa Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Gly Asn Ala Asp Tyr Val Phe Xaa Ser Ile Phe 
    930                 935                 940                 


Xaa Leu Glu Ile Ile Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys Val Gly 
    1265                 1270                 1275             


Leu 
    


<210> 4653
<211> 2138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1561)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1614)..(1614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1674)..(1674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1723)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1752)..(1752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1831)..(1831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1836)..(1836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1845)..(1845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1856)..(1856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1870)..(1870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1918)..(1918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1954)..(1954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1958)..(1958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1971)..(1971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1998)..(1999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2059)..(2060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2070)..(2070)
<223> Selenocysteine

<400> 4653
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Xaa Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Xaa Xaa Ile Phe 
    930                 935                 940                 


Xaa Ile Glu Ile Ala Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys Gly Tyr 
    1265                 1270                 1275             


Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe Leu Ile  Val Ile Gly 
    1280                 1285                 1290             


Ser Ile  Ile Asp Val Ile Leu  Ser Glu Xaa Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Xaa Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Xaa Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Xaa Leu Leu  Trp Xaa Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Xaa  Xaa Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Xaa Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Xaa Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Xaa Glu Gly 
    1430                 1435                 1440             


Glu Xaa  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Xaa Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Xaa Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Xaa  Val Met Phe Asn Ala  Xaa Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Xaa Ala Leu  Arg Ile Lys Xaa Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Xaa Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Xaa Val  Gly Lys Phe Tyr Ala  Xaa Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Xaa Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Xaa Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Gly Arg  Ser Ala Phe Pro Gln  Xaa Phe Xaa Xaa Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly Asp Xaa  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Xaa Phe Xaa Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Xaa Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Xaa 
    1760                 1765                 1770             


Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly Tyr Pro  Ser Xaa Val 
    1775                 1780                 1785             


Ser Xaa  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg 
    1790                 1795                 1800             


Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser Asn Arg  Cys His Ser 
    1805                 1810                 1815             


Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln Glu Glu  Xaa Ser Gln 
    1820                 1825                 1830             


Asp Glu  Xaa Tyr Glu Val Lys  Met Asn His Asp Xaa  Glu Ala Cys 
    1835                 1840                 1845             


Ser Glu  Pro Ser Leu Leu Ser  Xaa Glu Met Leu Ser  Tyr Gln Asp 
    1850                 1855                 1860             


Asp Glu  Asn Arg Gln Leu Xaa  Leu Pro Glu Glu Asp  Lys Arg Asp 
    1865                 1870                 1875             


Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu Arg Ser  Ala Ser Leu 
    1880                 1885                 1890             


Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys Leu Lys  Arg Gln Lys 
    1895                 1900                 1905             


Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Xaa Val Leu  Pro Leu His 
    1910                 1915                 1920             


Leu Val  His His Gln Ala Leu  Ala Val Ala Gly Leu  Ser Pro Leu 
    1925                 1930                 1935             


Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe Pro Arg  Pro Phe Ala 
    1940                 1945                 1950             


Xaa Pro  Pro Ala Xaa Pro Gly  Ser Arg Gly Trp Pro  Pro Gln Pro 
    1955                 1960                 1965             


Val Pro  Xaa Leu Arg Leu Glu  Gly Val Glu Ser Ser  Glu Lys Leu 
    1970                 1975                 1980             


Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly Ser Trp  Ala Glu Xaa 
    1985                 1990                 1995             


Xaa Pro  Gly Gly Gly Gly Ser  Ser Ala Ala Arg Arg  Val Arg Pro 
    2000                 2005                 2010             


Val Ser  Leu Met Val Pro Ser  Gln Ala Gly Ala Pro  Gly Arg Gln 
    2015                 2020                 2025             


Phe His  Gly Ser Ala Ser Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2030                 2035                 2040             


Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro Lys Phe  Ile Glu Val 
    2045                 2050                 2055             


Xaa Xaa  Gln Glu Leu Ala Asp  Ala Cys Asp Met Xaa  Ile Glu Glu 
    2060                 2065                 2070             


Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser Gly Gly  Ala Pro Gln 
    2075                 2080                 2085             


Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val Asn Cys  Arg Asp Ala 
    2090                 2095                 2100             


Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp Ala Gly  Cys Val Arg 
    2105                 2110                 2115             


Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu Gln Asp  Ser Arg Val 
    2120                 2125                 2130             


Tyr Val  Ser Ser Leu 
    2135             


<210> 4654
<211> 2138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1561)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1614)..(1614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1674)..(1674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1723)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1752)..(1752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1831)..(1831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1836)..(1836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1845)..(1845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1856)..(1856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1870)..(1870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1918)..(1918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1954)..(1954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1958)..(1958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1971)..(1971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1998)..(1999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2059)..(2060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2070)..(2070)
<223> Selenocysteine

<400> 4654
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Xaa Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Gly Asn Ala Asp Tyr Val Phe Xaa Ser Ile Phe 
    930                 935                 940                 


Xaa Leu Glu Ile Ile Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Xaa  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Xaa Glu Val Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Xaa Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Xaa Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Xaa Leu Leu  Trp Xaa Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Xaa  Xaa Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Xaa Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Xaa Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Xaa Glu Gly 
    1430                 1435                 1440             


Glu Xaa  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Xaa Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Xaa Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Xaa  Val Met Phe Asn Ala  Xaa Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Xaa Ala Leu  Arg Ile Lys Xaa Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Xaa Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Xaa Val  Gly Lys Phe Tyr Ala  Xaa Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Xaa Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Xaa Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Gly Arg  Ser Ala Phe Pro Gln  Xaa Phe Xaa Xaa Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly Asp Xaa  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Xaa Phe Xaa Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Xaa Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Xaa 
    1760                 1765                 1770             


Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly Tyr Pro  Ser Xaa Val 
    1775                 1780                 1785             


Ser Xaa  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg 
    1790                 1795                 1800             


Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser Asn Arg  Cys His Ser 
    1805                 1810                 1815             


Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln Glu Glu  Xaa Ser Gln 
    1820                 1825                 1830             


Asp Glu  Xaa Tyr Glu Val Lys  Met Asn His Asp Xaa  Glu Ala Cys 
    1835                 1840                 1845             


Ser Glu  Pro Ser Leu Leu Ser  Xaa Glu Met Leu Ser  Tyr Gln Asp 
    1850                 1855                 1860             


Asp Glu  Asn Arg Gln Leu Xaa  Leu Pro Glu Glu Asp  Lys Arg Asp 
    1865                 1870                 1875             


Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu Arg Ser  Ala Ser Leu 
    1880                 1885                 1890             


Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys Leu Lys  Arg Gln Lys 
    1895                 1900                 1905             


Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Xaa Val Leu  Pro Leu His 
    1910                 1915                 1920             


Leu Val  His His Gln Ala Leu  Ala Val Ala Gly Leu  Ser Pro Leu 
    1925                 1930                 1935             


Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe Pro Arg  Pro Phe Ala 
    1940                 1945                 1950             


Xaa Pro  Pro Ala Xaa Pro Gly  Ser Arg Gly Trp Pro  Pro Gln Pro 
    1955                 1960                 1965             


Val Pro  Xaa Leu Arg Leu Glu  Gly Val Glu Ser Ser  Glu Lys Leu 
    1970                 1975                 1980             


Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly Ser Trp  Ala Glu Xaa 
    1985                 1990                 1995             


Xaa Pro  Gly Gly Gly Gly Ser  Ser Ala Ala Arg Arg  Val Arg Pro 
    2000                 2005                 2010             


Val Ser  Leu Met Val Pro Ser  Gln Ala Gly Ala Pro  Gly Arg Gln 
    2015                 2020                 2025             


Phe His  Gly Ser Ala Ser Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2030                 2035                 2040             


Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro Lys Phe  Ile Glu Val 
    2045                 2050                 2055             


Xaa Xaa  Gln Glu Leu Ala Asp  Ala Cys Asp Met Xaa  Ile Glu Glu 
    2060                 2065                 2070             


Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser Gly Gly  Ala Pro Gln 
    2075                 2080                 2085             


Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val Asn Cys  Arg Asp Ala 
    2090                 2095                 2100             


Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp Ala Gly  Cys Val Arg 
    2105                 2110                 2115             


Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu Gln Asp  Ser Arg Val 
    2120                 2125                 2130             


Tyr Val  Ser Ser Leu 
    2135             


<210> 4655
<211> 2138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1561)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1614)..(1614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1674)..(1674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1723)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1752)..(1752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1831)..(1831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1836)..(1836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1845)..(1845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1856)..(1856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1870)..(1870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1918)..(1918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1954)..(1954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1958)..(1958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1971)..(1971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1998)..(1999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2059)..(2060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2070)..(2070)
<223> Selenocysteine

<400> 4655
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr 
    370                 375                 380                 


Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Xaa Xaa Ile Phe 
    930                 935                 940                 


Xaa Ile Glu Ile Ala Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys Gly Tyr 
    1265                 1270                 1275             


Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe Leu Ile  Val Ile Gly 
    1280                 1285                 1290             


Ser Ile  Ile Asp Val Ile Leu  Ser Glu Xaa Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Xaa Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Xaa Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Xaa Leu Leu  Trp Xaa Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Xaa  Xaa Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Xaa Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Xaa Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Xaa Glu Gly 
    1430                 1435                 1440             


Glu Xaa  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Xaa Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Xaa Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Xaa  Val Met Phe Asn Ala  Xaa Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Xaa Ala Leu  Arg Ile Lys Xaa Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Xaa Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Xaa Val  Gly Lys Phe Tyr Ala  Xaa Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Xaa Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Xaa Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Gly Arg  Ser Ala Phe Pro Gln  Xaa Phe Xaa Xaa Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly Asp Xaa  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Xaa Phe Xaa Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Xaa Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Xaa 
    1760                 1765                 1770             


Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly Tyr Pro  Ser Xaa Val 
    1775                 1780                 1785             


Ser Xaa  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg 
    1790                 1795                 1800             


Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser Asn Arg  Cys His Ser 
    1805                 1810                 1815             


Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln Glu Glu  Xaa Ser Gln 
    1820                 1825                 1830             


Asp Glu  Xaa Tyr Glu Val Lys  Met Asn His Asp Xaa  Glu Ala Cys 
    1835                 1840                 1845             


Ser Glu  Pro Ser Leu Leu Ser  Xaa Glu Met Leu Ser  Tyr Gln Asp 
    1850                 1855                 1860             


Asp Glu  Asn Arg Gln Leu Xaa  Leu Pro Glu Glu Asp  Lys Arg Asp 
    1865                 1870                 1875             


Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu Arg Ser  Ala Ser Leu 
    1880                 1885                 1890             


Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys Leu Lys  Arg Gln Lys 
    1895                 1900                 1905             


Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Xaa Val Leu  Pro Leu His 
    1910                 1915                 1920             


Leu Val  His His Gln Ala Leu  Ala Val Ala Gly Leu  Ser Pro Leu 
    1925                 1930                 1935             


Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe Pro Arg  Pro Phe Ala 
    1940                 1945                 1950             


Xaa Pro  Pro Ala Xaa Pro Gly  Ser Arg Gly Trp Pro  Pro Gln Pro 
    1955                 1960                 1965             


Val Pro  Xaa Leu Arg Leu Glu  Gly Val Glu Ser Ser  Glu Lys Leu 
    1970                 1975                 1980             


Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly Ser Trp  Ala Glu Xaa 
    1985                 1990                 1995             


Xaa Pro  Gly Gly Gly Gly Ser  Ser Ala Ala Arg Arg  Val Arg Pro 
    2000                 2005                 2010             


Val Ser  Leu Met Val Pro Ser  Gln Ala Gly Ala Pro  Gly Arg Gln 
    2015                 2020                 2025             


Phe His  Gly Ser Ala Ser Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2030                 2035                 2040             


Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro Lys Phe  Ile Glu Val 
    2045                 2050                 2055             


Xaa Xaa  Gln Glu Leu Ala Asp  Ala Cys Asp Met Xaa  Ile Glu Glu 
    2060                 2065                 2070             


Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser Gly Gly  Ala Pro Gln 
    2075                 2080                 2085             


Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val Asn Cys  Arg Asp Ala 
    2090                 2095                 2100             


Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp Ala Gly  Cys Val Arg 
    2105                 2110                 2115             


Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu Gln Asp  Ser Arg Val 
    2120                 2125                 2130             


Tyr Val  Ser Ser Leu 
    2135             


<210> 4656
<211> 2138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1561)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1614)..(1614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1674)..(1674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1723)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1752)..(1752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1831)..(1831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1836)..(1836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1845)..(1845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1856)..(1856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1870)..(1870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1918)..(1918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1954)..(1954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1958)..(1958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1971)..(1971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1998)..(1999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2059)..(2060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2070)..(2070)
<223> Selenocysteine

<400> 4656
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr 
    370                 375                 380                 


Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Gly Asn Ala Asp Tyr Val Phe Xaa Ser Ile Phe 
    930                 935                 940                 


Xaa Leu Glu Ile Ile Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Xaa  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Xaa Glu Val Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Xaa Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Xaa Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Xaa Leu Leu  Trp Xaa Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Xaa  Xaa Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Xaa Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Xaa Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Xaa Glu Gly 
    1430                 1435                 1440             


Glu Xaa  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Xaa Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Xaa Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Xaa  Val Met Phe Asn Ala  Xaa Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Xaa Ala Leu  Arg Ile Lys Xaa Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Xaa Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Xaa Val  Gly Lys Phe Tyr Ala  Xaa Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Xaa Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Xaa Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Gly Arg  Ser Ala Phe Pro Gln  Xaa Phe Xaa Xaa Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly Asp Xaa  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Xaa Phe Xaa Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Xaa Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Xaa 
    1760                 1765                 1770             


Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly Tyr Pro  Ser Xaa Val 
    1775                 1780                 1785             


Ser Xaa  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg 
    1790                 1795                 1800             


Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser Asn Arg  Cys His Ser 
    1805                 1810                 1815             


Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln Glu Glu  Xaa Ser Gln 
    1820                 1825                 1830             


Asp Glu  Xaa Tyr Glu Val Lys  Met Asn His Asp Xaa  Glu Ala Cys 
    1835                 1840                 1845             


Ser Glu  Pro Ser Leu Leu Ser  Xaa Glu Met Leu Ser  Tyr Gln Asp 
    1850                 1855                 1860             


Asp Glu  Asn Arg Gln Leu Xaa  Leu Pro Glu Glu Asp  Lys Arg Asp 
    1865                 1870                 1875             


Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu Arg Ser  Ala Ser Leu 
    1880                 1885                 1890             


Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys Leu Lys  Arg Gln Lys 
    1895                 1900                 1905             


Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Xaa Val Leu  Pro Leu His 
    1910                 1915                 1920             


Leu Val  His His Gln Ala Leu  Ala Val Ala Gly Leu  Ser Pro Leu 
    1925                 1930                 1935             


Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe Pro Arg  Pro Phe Ala 
    1940                 1945                 1950             


Xaa Pro  Pro Ala Xaa Pro Gly  Ser Arg Gly Trp Pro  Pro Gln Pro 
    1955                 1960                 1965             


Val Pro  Xaa Leu Arg Leu Glu  Gly Val Glu Ser Ser  Glu Lys Leu 
    1970                 1975                 1980             


Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly Ser Trp  Ala Glu Xaa 
    1985                 1990                 1995             


Xaa Pro  Gly Gly Gly Gly Ser  Ser Ala Ala Arg Arg  Val Arg Pro 
    2000                 2005                 2010             


Val Ser  Leu Met Val Pro Ser  Gln Ala Gly Ala Pro  Gly Arg Gln 
    2015                 2020                 2025             


Phe His  Gly Ser Ala Ser Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2030                 2035                 2040             


Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro Lys Phe  Ile Glu Val 
    2045                 2050                 2055             


Xaa Xaa  Gln Glu Leu Ala Asp  Ala Cys Asp Met Xaa  Ile Glu Glu 
    2060                 2065                 2070             


Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser Gly Gly  Ala Pro Gln 
    2075                 2080                 2085             


Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val Asn Cys  Arg Asp Ala 
    2090                 2095                 2100             


Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp Ala Gly  Cys Val Arg 
    2105                 2110                 2115             


Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu Gln Asp  Ser Arg Val 
    2120                 2125                 2130             


Tyr Val  Ser Ser Leu 
    2135             


<210> 4657
<211> 2138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1561)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1614)..(1614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1674)..(1674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1723)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1752)..(1752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1831)..(1831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1836)..(1836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1845)..(1845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1856)..(1856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1870)..(1870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1918)..(1918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1954)..(1954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1958)..(1958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1971)..(1971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1998)..(1999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2059)..(2060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2070)..(2070)
<223> Selenocysteine

<400> 4657
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Xaa Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Gly Asn Ala Asp Tyr Val Phe Xaa Ser Ile Phe 
    930                 935                 940                 


Xaa Leu Glu Ile Ile Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys Gly Tyr 
    1265                 1270                 1275             


Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe Leu Ile  Val Ile Gly 
    1280                 1285                 1290             


Ser Ile  Ile Asp Val Ile Leu  Ser Glu Xaa Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Xaa Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Xaa Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Xaa Leu Leu  Trp Xaa Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Xaa  Xaa Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Xaa Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Xaa Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Xaa Glu Gly 
    1430                 1435                 1440             


Glu Xaa  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Xaa Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Xaa Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Xaa  Val Met Phe Asn Ala  Xaa Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Xaa Ala Leu  Arg Ile Lys Xaa Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Xaa Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Xaa Val  Gly Lys Phe Tyr Ala  Xaa Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Xaa Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Xaa Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Gly Arg  Ser Ala Phe Pro Gln  Xaa Phe Xaa Xaa Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly Asp Xaa  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Xaa Phe Xaa Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Xaa Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Xaa 
    1760                 1765                 1770             


Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly Tyr Pro  Ser Xaa Val 
    1775                 1780                 1785             


Ser Xaa  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg 
    1790                 1795                 1800             


Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser Asn Arg  Cys His Ser 
    1805                 1810                 1815             


Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln Glu Glu  Xaa Ser Gln 
    1820                 1825                 1830             


Asp Glu  Xaa Tyr Glu Val Lys  Met Asn His Asp Xaa  Glu Ala Cys 
    1835                 1840                 1845             


Ser Glu  Pro Ser Leu Leu Ser  Xaa Glu Met Leu Ser  Tyr Gln Asp 
    1850                 1855                 1860             


Asp Glu  Asn Arg Gln Leu Xaa  Leu Pro Glu Glu Asp  Lys Arg Asp 
    1865                 1870                 1875             


Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu Arg Ser  Ala Ser Leu 
    1880                 1885                 1890             


Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys Leu Lys  Arg Gln Lys 
    1895                 1900                 1905             


Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Xaa Val Leu  Pro Leu His 
    1910                 1915                 1920             


Leu Val  His His Gln Ala Leu  Ala Val Ala Gly Leu  Ser Pro Leu 
    1925                 1930                 1935             


Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe Pro Arg  Pro Phe Ala 
    1940                 1945                 1950             


Xaa Pro  Pro Ala Xaa Pro Gly  Ser Arg Gly Trp Pro  Pro Gln Pro 
    1955                 1960                 1965             


Val Pro  Xaa Leu Arg Leu Glu  Gly Val Glu Ser Ser  Glu Lys Leu 
    1970                 1975                 1980             


Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly Ser Trp  Ala Glu Xaa 
    1985                 1990                 1995             


Xaa Pro  Gly Gly Gly Gly Ser  Ser Ala Ala Arg Arg  Val Arg Pro 
    2000                 2005                 2010             


Val Ser  Leu Met Val Pro Ser  Gln Ala Gly Ala Pro  Gly Arg Gln 
    2015                 2020                 2025             


Phe His  Gly Ser Ala Ser Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2030                 2035                 2040             


Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro Lys Phe  Ile Glu Val 
    2045                 2050                 2055             


Xaa Xaa  Gln Glu Leu Ala Asp  Ala Cys Asp Met Xaa  Ile Glu Glu 
    2060                 2065                 2070             


Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser Gly Gly  Ala Pro Gln 
    2075                 2080                 2085             


Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val Asn Cys  Arg Asp Ala 
    2090                 2095                 2100             


Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp Ala Gly  Cys Val Arg 
    2105                 2110                 2115             


Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu Gln Asp  Ser Arg Val 
    2120                 2125                 2130             


Tyr Val  Ser Ser Leu 
    2135             


<210> 4658
<211> 2138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1561)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1614)..(1614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1674)..(1674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1723)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1752)..(1752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1831)..(1831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1836)..(1836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1845)..(1845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1856)..(1856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1870)..(1870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1918)..(1918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1954)..(1954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1958)..(1958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1971)..(1971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1998)..(1999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2059)..(2060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2070)..(2070)
<223> Selenocysteine

<400> 4658
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Xaa Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Xaa Xaa Ile Phe 
    930                 935                 940                 


Xaa Ile Glu Ile Ala Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Xaa  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Xaa Glu Val Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Xaa Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Xaa Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Xaa Leu Leu  Trp Xaa Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Xaa  Xaa Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Xaa Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Xaa Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Xaa Glu Gly 
    1430                 1435                 1440             


Glu Xaa  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Xaa Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Xaa Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Xaa  Val Met Phe Asn Ala  Xaa Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Xaa Ala Leu  Arg Ile Lys Xaa Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Xaa Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Xaa Val  Gly Lys Phe Tyr Ala  Xaa Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Xaa Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Xaa Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Gly Arg  Ser Ala Phe Pro Gln  Xaa Phe Xaa Xaa Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly Asp Xaa  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Xaa Phe Xaa Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Xaa Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Xaa 
    1760                 1765                 1770             


Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly Tyr Pro  Ser Xaa Val 
    1775                 1780                 1785             


Ser Xaa  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg 
    1790                 1795                 1800             


Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser Asn Arg  Cys His Ser 
    1805                 1810                 1815             


Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln Glu Glu  Xaa Ser Gln 
    1820                 1825                 1830             


Asp Glu  Xaa Tyr Glu Val Lys  Met Asn His Asp Xaa  Glu Ala Cys 
    1835                 1840                 1845             


Ser Glu  Pro Ser Leu Leu Ser  Xaa Glu Met Leu Ser  Tyr Gln Asp 
    1850                 1855                 1860             


Asp Glu  Asn Arg Gln Leu Xaa  Leu Pro Glu Glu Asp  Lys Arg Asp 
    1865                 1870                 1875             


Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu Arg Ser  Ala Ser Leu 
    1880                 1885                 1890             


Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys Leu Lys  Arg Gln Lys 
    1895                 1900                 1905             


Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Xaa Val Leu  Pro Leu His 
    1910                 1915                 1920             


Leu Val  His His Gln Ala Leu  Ala Val Ala Gly Leu  Ser Pro Leu 
    1925                 1930                 1935             


Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe Pro Arg  Pro Phe Ala 
    1940                 1945                 1950             


Xaa Pro  Pro Ala Xaa Pro Gly  Ser Arg Gly Trp Pro  Pro Gln Pro 
    1955                 1960                 1965             


Val Pro  Xaa Leu Arg Leu Glu  Gly Val Glu Ser Ser  Glu Lys Leu 
    1970                 1975                 1980             


Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly Ser Trp  Ala Glu Xaa 
    1985                 1990                 1995             


Xaa Pro  Gly Gly Gly Gly Ser  Ser Ala Ala Arg Arg  Val Arg Pro 
    2000                 2005                 2010             


Val Ser  Leu Met Val Pro Ser  Gln Ala Gly Ala Pro  Gly Arg Gln 
    2015                 2020                 2025             


Phe His  Gly Ser Ala Ser Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2030                 2035                 2040             


Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro Lys Phe  Ile Glu Val 
    2045                 2050                 2055             


Xaa Xaa  Gln Glu Leu Ala Asp  Ala Cys Asp Met Xaa  Ile Glu Glu 
    2060                 2065                 2070             


Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser Gly Gly  Ala Pro Gln 
    2075                 2080                 2085             


Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val Asn Cys  Arg Asp Ala 
    2090                 2095                 2100             


Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp Ala Gly  Cys Val Arg 
    2105                 2110                 2115             


Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu Gln Asp  Ser Arg Val 
    2120                 2125                 2130             


Tyr Val  Ser Ser Leu 
    2135             


<210> 4659
<211> 2144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1313)..(1313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1339)..(1339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1377)..(1378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1388)..(1388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1428)..(1428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1432)..(1432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1470)..(1470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1548)..(1548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1561)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1602)..(1602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1620)..(1620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1627)..(1627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1663)..(1663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1680)..(1680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1727)..(1727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1729)..(1730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1746)..(1746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1758)..(1758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1767)..(1767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1779)..(1779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1793)..(1793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1796)..(1796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1837)..(1837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1842)..(1842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1851)..(1851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1862)..(1862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1876)..(1876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1924)..(1924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1960)..(1960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1964)..(1964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1977)..(1977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2004)..(2005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2065)..(2066)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2076)..(2076)
<223> Selenocysteine

<400> 4659
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Xaa Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Xaa Xaa Ile Phe 
    930                 935                 940                 


Xaa Ile Glu Ile Ala Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Xaa  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Xaa Glu Asn Ala Glu  Glu Asn Ser 
    1295                 1300                 1305             


Arg Ile  Ser Ile Xaa Phe Phe  Arg Leu Phe Arg Val  Met Arg Leu 
    1310                 1315                 1320             


Val Lys  Leu Leu Ser Arg Gly  Glu Gly Ile Arg Xaa  Leu Leu Trp 
    1325                 1330                 1335             


Xaa Phe  Ile Lys Ser Phe Gln  Ala Leu Pro Tyr Val  Ala Leu Leu 
    1340                 1345                 1350             


Ile Val  Met Leu Phe Phe Ile  Tyr Ala Val Ile Gly  Met Gln Val 
    1355                 1360                 1365             


Phe Gly  Lys Ile Ala Leu Asn  Asp Xaa Xaa Glu Ile  Asn Arg Asn 
    1370                 1375                 1380             


Asn Asn  Phe Gln Xaa Phe Pro  Gln Ala Val Leu Leu  Leu Phe Arg 
    1385                 1390                 1395             


Cys Ala  Xaa Gly Glu Ala Trp  Gln Asp Ile Met Leu  Ala Cys Met 
    1400                 1405                 1410             


Pro Gly  Lys Lys Cys Ala Pro  Glu Ser Glu Pro Ser  Asn Ser Xaa 
    1415                 1420                 1425             


Glu Gly  Glu Xaa Pro Cys Gly  Ser Ser Phe Ala Val  Phe Tyr Phe 
    1430                 1435                 1440             


Ile Ser  Phe Tyr Met Leu Cys  Ala Phe Leu Ile Ile  Asn Leu Phe 
    1445                 1450                 1455             


Val Ala  Val Ile Met Asp Asn  Phe Asp Tyr Leu Xaa  Arg Asp Trp 
    1460                 1465                 1470             


Ser Ile  Leu Gly Pro His His  Leu Asp Glu Phe Lys  Arg Ile Trp 
    1475                 1480                 1485             


Ala Glu  Tyr Asp Pro Glu Ala  Lys Gly Arg Ile Lys  His Leu Asp 
    1490                 1495                 1500             


Val Val  Xaa Leu Leu Arg Arg  Ile Gln Pro Pro Leu  Gly Phe Gly 
    1505                 1510                 1515             


Lys Leu  Cys Pro His Arg Val  Ala Cys Lys Arg Leu  Val Ser Met 
    1520                 1525                 1530             


Asn Met  Pro Leu Asn Ser Asp  Gly Xaa Val Met Phe  Asn Ala Xaa 
    1535                 1540                 1545             


Leu Phe  Ala Leu Val Arg Xaa  Ala Leu Arg Ile Lys  Xaa Glu Glu 
    1550                 1555                 1560             


Gly Pro  Ser Pro Ser Glu Ala  His Gln Gly Ala Glu  Asp Pro Phe 
    1565                 1570                 1575             


Arg Pro  Ala Gly Asn Leu Glu  Gln Ala Asn Glu Glu  Leu Arg Ala 
    1580                 1585                 1590             


Ile Ile  Lys Lys Ile Trp Lys  Arg Xaa Ser Met Lys  Leu Leu Asp 
    1595                 1600                 1605             


Gln Val  Val Pro Pro Ala Gly  Asp Asp Glu Val Xaa  Val Gly Lys 
    1610                 1615                 1620             


Phe Tyr  Ala Xaa Phe Leu Ile  Gln Glu Tyr Phe Arg  Lys Phe Lys 
    1625                 1630                 1635             


Lys Arg  Lys Glu Gln Gly Leu  Val Gly Lys Pro Ser  Gln Arg Asn 
    1640                 1645                 1650             


Ala Leu  Ser Leu Gln Ala Gly  Leu Arg Xaa Leu His  Asp Ile Gly 
    1655                 1660                 1665             


Pro Glu  Ile Arg Arg Ala Ile  Ser Gly Asp Leu Xaa  Ala Glu Glu 
    1670                 1675                 1680             


Glu Leu  Asp Lys Ala Met Lys  Glu Ala Val Ser Ala  Ala Ser Glu 
    1685                 1690                 1695             


Asp Asp  Ile Phe Arg Arg Ala  Gly Gly Leu Phe Gly  Asn His Val 
    1700                 1705                 1710             


Ser Tyr  Tyr Gln Ser Asp Gly  Arg Ser Ala Phe Pro  Gln Xaa Phe 
    1715                 1720                 1725             


Xaa Xaa  Gln Arg Pro Leu His  Ile Asn Lys Ala Gly  Ser Ser Gln 
    1730                 1735                 1740             


Gly Asp  Xaa Glu Ser Pro Ser  His Glu Lys Leu Val  Asp Ser Xaa 
    1745                 1750                 1755             


Phe Xaa  Pro Ser Ser Tyr Ser  Ser Xaa Gly Ser Asn  Ala Asn Ile 
    1760                 1765                 1770             


Asn Asn  Ala Asn Asn Xaa Ala  Leu Gly Arg Leu Pro  Arg Pro Ala 
    1775                 1780                 1785             


Gly Tyr  Pro Ser Xaa Val Ser  Xaa Val Glu Gly His  Gly Pro Pro 
    1790                 1795                 1800             


Leu Ser  Pro Ala Ile Arg Val  Gln Glu Val Ala Trp  Lys Leu Ser 
    1805                 1810                 1815             


Ser Asn  Arg Cys His Ser Arg  Glu Ser Gln Ala Ala  Met Ala Gly 
    1820                 1825                 1830             


Gln Glu  Glu Xaa Ser Gln Asp  Glu Xaa Tyr Glu Val  Lys Met Asn 
    1835                 1840                 1845             


His Asp  Xaa Glu Ala Cys Ser  Glu Pro Ser Leu Leu  Ser Xaa Glu 
    1850                 1855                 1860             


Met Leu  Ser Tyr Gln Asp Asp  Glu Asn Arg Gln Leu  Xaa Leu Pro 
    1865                 1870                 1875             


Glu Glu  Asp Lys Arg Asp Ile  Arg Gln Ser Pro Lys  Arg Gly Phe 
    1880                 1885                 1890             


Leu Arg  Ser Ala Ser Leu Gly  Arg Arg Ala Ser Phe  His Leu Glu 
    1895                 1900                 1905             


Cys Leu  Lys Arg Gln Lys Asp  Arg Gly Gly Asp Ile  Ser Gln Lys 
    1910                 1915                 1920             


Xaa Val  Leu Pro Leu His Leu  Val His His Gln Ala  Leu Ala Val 
    1925                 1930                 1935             


Ala Gly  Leu Ser Pro Leu Leu  Gln Arg Ser His Ser  Pro Ala Ser 
    1940                 1945                 1950             


Phe Pro  Arg Pro Phe Ala Xaa  Pro Pro Ala Xaa Pro  Gly Ser Arg 
    1955                 1960                 1965             


Gly Trp  Pro Pro Gln Pro Val  Pro Xaa Leu Arg Leu  Glu Gly Val 
    1970                 1975                 1980             


Glu Ser  Ser Glu Lys Leu Asn  Ser Ser Phe Pro Ser  Ile His Cys 
    1985                 1990                 1995             


Gly Ser  Trp Ala Glu Xaa Xaa  Pro Gly Gly Gly Gly  Ser Ser Ala 
    2000                 2005                 2010             


Ala Arg  Arg Val Arg Pro Val  Ser Leu Met Val Pro  Ser Gln Ala 
    2015                 2020                 2025             


Gly Ala  Pro Gly Arg Gln Phe  His Gly Ser Ala Ser  Ser Leu Val 
    2030                 2035                 2040             


Glu Ala  Val Leu Ile Ser Glu  Gly Leu Gly Gln Phe  Ala Gln Asp 
    2045                 2050                 2055             


Pro Lys  Phe Ile Glu Val Xaa  Xaa Gln Glu Leu Ala  Asp Ala Cys 
    2060                 2065                 2070             


Asp Met  Xaa Ile Glu Glu Met  Glu Ser Ala Ala Asp  Asn Ile Leu 
    2075                 2080                 2085             


Ser Gly  Gly Ala Pro Gln Ser  Pro Asn Gly Ala Leu  Leu Pro Phe 
    2090                 2095                 2100             


Val Asn  Cys Arg Asp Ala Gly  Gln Asp Arg Ala Gly  Gly Glu Glu 
    2105                 2110                 2115             


Asp Ala  Gly Cys Val Arg Ala  Arg Gly Arg Pro Ser  Glu Glu Glu 
    2120                 2125                 2130             


Leu Gln  Asp Ser Arg Val Tyr  Val Ser Ser Leu 
    2135                 2140                 


<210> 4660
<211> 2146
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1315)..(1315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1379)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1403)..(1403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1430)..(1430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1508)..(1508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1544)..(1544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1550)..(1550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1557)..(1557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1563)..(1563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1604)..(1604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1622)..(1622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1629)..(1629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1665)..(1665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1682)..(1682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1729)..(1729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1731)..(1732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1748)..(1748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1762)..(1762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1769)..(1769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1781)..(1781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1795)..(1795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1798)..(1798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1839)..(1839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1844)..(1844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1853)..(1853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1864)..(1864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1878)..(1878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1926)..(1926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1962)..(1962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1966)..(1966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1979)..(1979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2006)..(2007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2067)..(2068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2078)..(2078)
<223> Selenocysteine

<400> 4660
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Xaa Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Gly Asn Ala Asp Tyr Val Phe Xaa Ser Ile Phe 
    930                 935                 940                 


Xaa Leu Glu Ile Ile Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Xaa  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Xaa Glu Val Asn Asn  Ala Glu Glu 
    1295                 1300                 1305             


Asn Ser  Arg Ile Ser Ile Xaa  Phe Phe Arg Leu Phe  Arg Val Met 
    1310                 1315                 1320             


Arg Leu  Val Lys Leu Leu Ser  Arg Gly Glu Gly Ile  Arg Xaa Leu 
    1325                 1330                 1335             


Leu Trp  Xaa Phe Ile Lys Ser  Phe Gln Ala Leu Pro  Tyr Val Ala 
    1340                 1345                 1350             


Leu Leu  Ile Val Met Leu Phe  Phe Ile Tyr Ala Val  Ile Gly Met 
    1355                 1360                 1365             


Gln Val  Phe Gly Lys Ile Ala  Leu Asn Asp Xaa Xaa  Glu Ile Asn 
    1370                 1375                 1380             


Arg Asn  Asn Asn Phe Gln Xaa  Phe Pro Gln Ala Val  Leu Leu Leu 
    1385                 1390                 1395             


Phe Arg  Cys Ala Xaa Gly Glu  Ala Trp Gln Asp Ile  Met Leu Ala 
    1400                 1405                 1410             


Cys Met  Pro Gly Lys Lys Cys  Ala Pro Glu Ser Glu  Pro Ser Asn 
    1415                 1420                 1425             


Ser Xaa  Glu Gly Glu Xaa Pro  Cys Gly Ser Ser Phe  Ala Val Phe 
    1430                 1435                 1440             


Tyr Phe  Ile Ser Phe Tyr Met  Leu Cys Ala Phe Leu  Ile Ile Asn 
    1445                 1450                 1455             


Leu Phe  Val Ala Val Ile Met  Asp Asn Phe Asp Tyr  Leu Xaa Arg 
    1460                 1465                 1470             


Asp Trp  Ser Ile Leu Gly Pro  His His Leu Asp Glu  Phe Lys Arg 
    1475                 1480                 1485             


Ile Trp  Ala Glu Tyr Asp Pro  Glu Ala Lys Gly Arg  Ile Lys His 
    1490                 1495                 1500             


Leu Asp  Val Val Xaa Leu Leu  Arg Arg Ile Gln Pro  Pro Leu Gly 
    1505                 1510                 1515             


Phe Gly  Lys Leu Cys Pro His  Arg Val Ala Cys Lys  Arg Leu Val 
    1520                 1525                 1530             


Ser Met  Asn Met Pro Leu Asn  Ser Asp Gly Xaa Val  Met Phe Asn 
    1535                 1540                 1545             


Ala Xaa  Leu Phe Ala Leu Val  Arg Xaa Ala Leu Arg  Ile Lys Xaa 
    1550                 1555                 1560             


Glu Glu  Gly Pro Ser Pro Ser  Glu Ala His Gln Gly  Ala Glu Asp 
    1565                 1570                 1575             


Pro Phe  Arg Pro Ala Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu 
    1580                 1585                 1590             


Arg Ala  Ile Ile Lys Lys Ile  Trp Lys Arg Xaa Ser  Met Lys Leu 
    1595                 1600                 1605             


Leu Asp  Gln Val Val Pro Pro  Ala Gly Asp Asp Glu  Val Xaa Val 
    1610                 1615                 1620             


Gly Lys  Phe Tyr Ala Xaa Phe  Leu Ile Gln Glu Tyr  Phe Arg Lys 
    1625                 1630                 1635             


Phe Lys  Lys Arg Lys Glu Gln  Gly Leu Val Gly Lys  Pro Ser Gln 
    1640                 1645                 1650             


Arg Asn  Ala Leu Ser Leu Gln  Ala Gly Leu Arg Xaa  Leu His Asp 
    1655                 1660                 1665             


Ile Gly  Pro Glu Ile Arg Arg  Ala Ile Ser Gly Asp  Leu Xaa Ala 
    1670                 1675                 1680             


Glu Glu  Glu Leu Asp Lys Ala  Met Lys Glu Ala Val  Ser Ala Ala 
    1685                 1690                 1695             


Ser Glu  Asp Asp Ile Phe Arg  Arg Ala Gly Gly Leu  Phe Gly Asn 
    1700                 1705                 1710             


His Val  Ser Tyr Tyr Gln Ser  Asp Gly Arg Ser Ala  Phe Pro Gln 
    1715                 1720                 1725             


Xaa Phe  Xaa Xaa Gln Arg Pro  Leu His Ile Asn Lys  Ala Gly Ser 
    1730                 1735                 1740             


Ser Gln  Gly Asp Xaa Glu Ser  Pro Ser His Glu Lys  Leu Val Asp 
    1745                 1750                 1755             


Ser Xaa  Phe Xaa Pro Ser Ser  Tyr Ser Ser Xaa Gly  Ser Asn Ala 
    1760                 1765                 1770             


Asn Ile  Asn Asn Ala Asn Asn  Xaa Ala Leu Gly Arg  Leu Pro Arg 
    1775                 1780                 1785             


Pro Ala  Gly Tyr Pro Ser Xaa  Val Ser Xaa Val Glu  Gly His Gly 
    1790                 1795                 1800             


Pro Pro  Leu Ser Pro Ala Ile  Arg Val Gln Glu Val  Ala Trp Lys 
    1805                 1810                 1815             


Leu Ser  Ser Asn Arg Cys His  Ser Arg Glu Ser Gln  Ala Ala Met 
    1820                 1825                 1830             


Ala Gly  Gln Glu Glu Xaa Ser  Gln Asp Glu Xaa Tyr  Glu Val Lys 
    1835                 1840                 1845             


Met Asn  His Asp Xaa Glu Ala  Cys Ser Glu Pro Ser  Leu Leu Ser 
    1850                 1855                 1860             


Xaa Glu  Met Leu Ser Tyr Gln  Asp Asp Glu Asn Arg  Gln Leu Xaa 
    1865                 1870                 1875             


Leu Pro  Glu Glu Asp Lys Arg  Asp Ile Arg Gln Ser  Pro Lys Arg 
    1880                 1885                 1890             


Gly Phe  Leu Arg Ser Ala Ser  Leu Gly Arg Arg Ala  Ser Phe His 
    1895                 1900                 1905             


Leu Glu  Cys Leu Lys Arg Gln  Lys Asp Arg Gly Gly  Asp Ile Ser 
    1910                 1915                 1920             


Gln Lys  Xaa Val Leu Pro Leu  His Leu Val His His  Gln Ala Leu 
    1925                 1930                 1935             


Ala Val  Ala Gly Leu Ser Pro  Leu Leu Gln Arg Ser  His Ser Pro 
    1940                 1945                 1950             


Ala Ser  Phe Pro Arg Pro Phe  Ala Xaa Pro Pro Ala  Xaa Pro Gly 
    1955                 1960                 1965             


Ser Arg  Gly Trp Pro Pro Gln  Pro Val Pro Xaa Leu  Arg Leu Glu 
    1970                 1975                 1980             


Gly Val  Glu Ser Ser Glu Lys  Leu Asn Ser Ser Phe  Pro Ser Ile 
    1985                 1990                 1995             


His Cys  Gly Ser Trp Ala Glu  Xaa Xaa Pro Gly Gly  Gly Gly Ser 
    2000                 2005                 2010             


Ser Ala  Ala Arg Arg Val Arg  Pro Val Ser Leu Met  Val Pro Ser 
    2015                 2020                 2025             


Gln Ala  Gly Ala Pro Gly Arg  Gln Phe His Gly Ser  Ala Ser Ser 
    2030                 2035                 2040             


Leu Val  Glu Ala Val Leu Ile  Ser Glu Gly Leu Gly  Gln Phe Ala 
    2045                 2050                 2055             


Gln Asp  Pro Lys Phe Ile Glu  Val Xaa Xaa Gln Glu  Leu Ala Asp 
    2060                 2065                 2070             


Ala Cys  Asp Met Xaa Ile Glu  Glu Met Glu Ser Ala  Ala Asp Asn 
    2075                 2080                 2085             


Ile Leu  Ser Gly Gly Ala Pro  Gln Ser Pro Asn Gly  Ala Leu Leu 
    2090                 2095                 2100             


Pro Phe  Val Asn Cys Arg Asp  Ala Gly Gln Asp Arg  Ala Gly Gly 
    2105                 2110                 2115             


Glu Glu  Asp Ala Gly Cys Val  Arg Ala Arg Gly Arg  Pro Ser Glu 
    2120                 2125                 2130             


Glu Glu  Leu Gln Asp Ser Arg  Val Tyr Val Ser Ser  Leu 
    2135                 2140                 2145     


<210> 4661
<211> 2146
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1315)..(1315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1379)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1403)..(1403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1430)..(1430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1508)..(1508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1544)..(1544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1550)..(1550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1557)..(1557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1563)..(1563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1604)..(1604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1622)..(1622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1629)..(1629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1665)..(1665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1682)..(1682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1729)..(1729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1731)..(1732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1748)..(1748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1762)..(1762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1769)..(1769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1781)..(1781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1795)..(1795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1798)..(1798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1839)..(1839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1844)..(1844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1853)..(1853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1864)..(1864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1878)..(1878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1926)..(1926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1962)..(1962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1966)..(1966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1979)..(1979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2006)..(2007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2067)..(2068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2078)..(2078)
<223> Selenocysteine

<400> 4661
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Xaa Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Xaa Xaa Ile Phe 
    930                 935                 940                 


Xaa Ile Glu Ile Ala Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Xaa  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Xaa Glu Val Asn Asn  Ala Glu Glu 
    1295                 1300                 1305             


Asn Ser  Arg Ile Ser Ile Xaa  Phe Phe Arg Leu Phe  Arg Val Met 
    1310                 1315                 1320             


Arg Leu  Val Lys Leu Leu Ser  Arg Gly Glu Gly Ile  Arg Xaa Leu 
    1325                 1330                 1335             


Leu Trp  Xaa Phe Ile Lys Ser  Phe Gln Ala Leu Pro  Tyr Val Ala 
    1340                 1345                 1350             


Leu Leu  Ile Val Met Leu Phe  Phe Ile Tyr Ala Val  Ile Gly Met 
    1355                 1360                 1365             


Gln Val  Phe Gly Lys Ile Ala  Leu Asn Asp Xaa Xaa  Glu Ile Asn 
    1370                 1375                 1380             


Arg Asn  Asn Asn Phe Gln Xaa  Phe Pro Gln Ala Val  Leu Leu Leu 
    1385                 1390                 1395             


Phe Arg  Cys Ala Xaa Gly Glu  Ala Trp Gln Asp Ile  Met Leu Ala 
    1400                 1405                 1410             


Cys Met  Pro Gly Lys Lys Cys  Ala Pro Glu Ser Glu  Pro Ser Asn 
    1415                 1420                 1425             


Ser Xaa  Glu Gly Glu Xaa Pro  Cys Gly Ser Ser Phe  Ala Val Phe 
    1430                 1435                 1440             


Tyr Phe  Ile Ser Phe Tyr Met  Leu Cys Ala Phe Leu  Ile Ile Asn 
    1445                 1450                 1455             


Leu Phe  Val Ala Val Ile Met  Asp Asn Phe Asp Tyr  Leu Xaa Arg 
    1460                 1465                 1470             


Asp Trp  Ser Ile Leu Gly Pro  His His Leu Asp Glu  Phe Lys Arg 
    1475                 1480                 1485             


Ile Trp  Ala Glu Tyr Asp Pro  Glu Ala Lys Gly Arg  Ile Lys His 
    1490                 1495                 1500             


Leu Asp  Val Val Xaa Leu Leu  Arg Arg Ile Gln Pro  Pro Leu Gly 
    1505                 1510                 1515             


Phe Gly  Lys Leu Cys Pro His  Arg Val Ala Cys Lys  Arg Leu Val 
    1520                 1525                 1530             


Ser Met  Asn Met Pro Leu Asn  Ser Asp Gly Xaa Val  Met Phe Asn 
    1535                 1540                 1545             


Ala Xaa  Leu Phe Ala Leu Val  Arg Xaa Ala Leu Arg  Ile Lys Xaa 
    1550                 1555                 1560             


Glu Glu  Gly Pro Ser Pro Ser  Glu Ala His Gln Gly  Ala Glu Asp 
    1565                 1570                 1575             


Pro Phe  Arg Pro Ala Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu 
    1580                 1585                 1590             


Arg Ala  Ile Ile Lys Lys Ile  Trp Lys Arg Xaa Ser  Met Lys Leu 
    1595                 1600                 1605             


Leu Asp  Gln Val Val Pro Pro  Ala Gly Asp Asp Glu  Val Xaa Val 
    1610                 1615                 1620             


Gly Lys  Phe Tyr Ala Xaa Phe  Leu Ile Gln Glu Tyr  Phe Arg Lys 
    1625                 1630                 1635             


Phe Lys  Lys Arg Lys Glu Gln  Gly Leu Val Gly Lys  Pro Ser Gln 
    1640                 1645                 1650             


Arg Asn  Ala Leu Ser Leu Gln  Ala Gly Leu Arg Xaa  Leu His Asp 
    1655                 1660                 1665             


Ile Gly  Pro Glu Ile Arg Arg  Ala Ile Ser Gly Asp  Leu Xaa Ala 
    1670                 1675                 1680             


Glu Glu  Glu Leu Asp Lys Ala  Met Lys Glu Ala Val  Ser Ala Ala 
    1685                 1690                 1695             


Ser Glu  Asp Asp Ile Phe Arg  Arg Ala Gly Gly Leu  Phe Gly Asn 
    1700                 1705                 1710             


His Val  Ser Tyr Tyr Gln Ser  Asp Gly Arg Ser Ala  Phe Pro Gln 
    1715                 1720                 1725             


Xaa Phe  Xaa Xaa Gln Arg Pro  Leu His Ile Asn Lys  Ala Gly Ser 
    1730                 1735                 1740             


Ser Gln  Gly Asp Xaa Glu Ser  Pro Ser His Glu Lys  Leu Val Asp 
    1745                 1750                 1755             


Ser Xaa  Phe Xaa Pro Ser Ser  Tyr Ser Ser Xaa Gly  Ser Asn Ala 
    1760                 1765                 1770             


Asn Ile  Asn Asn Ala Asn Asn  Xaa Ala Leu Gly Arg  Leu Pro Arg 
    1775                 1780                 1785             


Pro Ala  Gly Tyr Pro Ser Xaa  Val Ser Xaa Val Glu  Gly His Gly 
    1790                 1795                 1800             


Pro Pro  Leu Ser Pro Ala Ile  Arg Val Gln Glu Val  Ala Trp Lys 
    1805                 1810                 1815             


Leu Ser  Ser Asn Arg Cys His  Ser Arg Glu Ser Gln  Ala Ala Met 
    1820                 1825                 1830             


Ala Gly  Gln Glu Glu Xaa Ser  Gln Asp Glu Xaa Tyr  Glu Val Lys 
    1835                 1840                 1845             


Met Asn  His Asp Xaa Glu Ala  Cys Ser Glu Pro Ser  Leu Leu Ser 
    1850                 1855                 1860             


Xaa Glu  Met Leu Ser Tyr Gln  Asp Asp Glu Asn Arg  Gln Leu Xaa 
    1865                 1870                 1875             


Leu Pro  Glu Glu Asp Lys Arg  Asp Ile Arg Gln Ser  Pro Lys Arg 
    1880                 1885                 1890             


Gly Phe  Leu Arg Ser Ala Ser  Leu Gly Arg Arg Ala  Ser Phe His 
    1895                 1900                 1905             


Leu Glu  Cys Leu Lys Arg Gln  Lys Asp Arg Gly Gly  Asp Ile Ser 
    1910                 1915                 1920             


Gln Lys  Xaa Val Leu Pro Leu  His Leu Val His His  Gln Ala Leu 
    1925                 1930                 1935             


Ala Val  Ala Gly Leu Ser Pro  Leu Leu Gln Arg Ser  His Ser Pro 
    1940                 1945                 1950             


Ala Ser  Phe Pro Arg Pro Phe  Ala Xaa Pro Pro Ala  Xaa Pro Gly 
    1955                 1960                 1965             


Ser Arg  Gly Trp Pro Pro Gln  Pro Val Pro Xaa Leu  Arg Leu Glu 
    1970                 1975                 1980             


Gly Val  Glu Ser Ser Glu Lys  Leu Asn Ser Ser Phe  Pro Ser Ile 
    1985                 1990                 1995             


His Cys  Gly Ser Trp Ala Glu  Xaa Xaa Pro Gly Gly  Gly Gly Ser 
    2000                 2005                 2010             


Ser Ala  Ala Arg Arg Val Arg  Pro Val Ser Leu Met  Val Pro Ser 
    2015                 2020                 2025             


Gln Ala  Gly Ala Pro Gly Arg  Gln Phe His Gly Ser  Ala Ser Ser 
    2030                 2035                 2040             


Leu Val  Glu Ala Val Leu Ile  Ser Glu Gly Leu Gly  Gln Phe Ala 
    2045                 2050                 2055             


Gln Asp  Pro Lys Phe Ile Glu  Val Xaa Xaa Gln Glu  Leu Ala Asp 
    2060                 2065                 2070             


Ala Cys  Asp Met Xaa Ile Glu  Glu Met Glu Ser Ala  Ala Asp Asn 
    2075                 2080                 2085             


Ile Leu  Ser Gly Gly Ala Pro  Gln Ser Pro Asn Gly  Ala Leu Leu 
    2090                 2095                 2100             


Pro Phe  Val Asn Cys Arg Asp  Ala Gly Gln Asp Arg  Ala Gly Gly 
    2105                 2110                 2115             


Glu Glu  Asp Ala Gly Cys Val  Arg Ala Arg Gly Arg  Pro Ser Glu 
    2120                 2125                 2130             


Glu Glu  Leu Gln Asp Ser Arg  Val Tyr Val Ser Ser  Leu 
    2135                 2140                 2145     


<210> 4662
<211> 2155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1313)..(1313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1343)..(1343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1365)..(1365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1369)..(1369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1418)..(1418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1431)..(1431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1462)..(1462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1500)..(1500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1536)..(1536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1572)..(1572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1578)..(1578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1585)..(1585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1591)..(1591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1613)..(1613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1631)..(1631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1638)..(1638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1674)..(1674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1691)..(1691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1738)..(1738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1757)..(1757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1769)..(1769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1771)..(1771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1778)..(1778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1804)..(1804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1807)..(1807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1848)..(1848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1853)..(1853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1862)..(1862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1873)..(1873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1887)..(1887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1935)..(1935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1971)..(1971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1975)..(1975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1988)..(1988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2015)..(2016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2076)..(2077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2087)..(2087)
<223> Selenocysteine

<400> 4662
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Xaa Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Gly Asn Ala Asp Tyr Val Phe Xaa Ser Ile Phe 
    930                 935                 940                 


Xaa Leu Glu Ile Ile Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys Gly Tyr 
    1265                 1270                 1275             


Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe Leu Ile  Val Ile Gly 
    1280                 1285                 1290             


Ser Ile  Ile Asp Val Ile Leu  Ser Glu Xaa Asn His  Tyr Phe Cys 
    1295                 1300                 1305             


Asp Ala  Trp Asn Xaa Phe Asp  Ala Leu Ile Val Val  Gly Ser Ile 
    1310                 1315                 1320             


Val Asp  Ile Ala Ile Xaa Glu  Val Asn Asn Ala Glu  Glu Asn Ser 
    1325                 1330                 1335             


Arg Ile  Ser Ile Xaa Phe Phe  Arg Leu Phe Arg Val  Met Arg Leu 
    1340                 1345                 1350             


Val Lys  Leu Leu Ser Arg Gly  Glu Gly Ile Arg Xaa  Leu Leu Trp 
    1355                 1360                 1365             


Xaa Phe  Ile Lys Ser Phe Gln  Ala Leu Pro Tyr Val  Ala Leu Leu 
    1370                 1375                 1380             


Ile Val  Met Leu Phe Phe Ile  Tyr Ala Val Ile Gly  Met Gln Val 
    1385                 1390                 1395             


Phe Gly  Lys Ile Ala Leu Asn  Asp Xaa Xaa Glu Ile  Asn Arg Asn 
    1400                 1405                 1410             


Asn Asn  Phe Gln Xaa Phe Pro  Gln Ala Val Leu Leu  Leu Phe Arg 
    1415                 1420                 1425             


Cys Ala  Xaa Gly Glu Ala Trp  Gln Asp Ile Met Leu  Ala Cys Met 
    1430                 1435                 1440             


Pro Gly  Lys Lys Cys Ala Pro  Glu Ser Glu Pro Ser  Asn Ser Xaa 
    1445                 1450                 1455             


Glu Gly  Glu Xaa Pro Cys Gly  Ser Ser Phe Ala Val  Phe Tyr Phe 
    1460                 1465                 1470             


Ile Ser  Phe Tyr Met Leu Cys  Ala Phe Leu Ile Ile  Asn Leu Phe 
    1475                 1480                 1485             


Val Ala  Val Ile Met Asp Asn  Phe Asp Tyr Leu Xaa  Arg Asp Trp 
    1490                 1495                 1500             


Ser Ile  Leu Gly Pro His His  Leu Asp Glu Phe Lys  Arg Ile Trp 
    1505                 1510                 1515             


Ala Glu  Tyr Asp Pro Glu Ala  Lys Gly Arg Ile Lys  His Leu Asp 
    1520                 1525                 1530             


Val Val  Xaa Leu Leu Arg Arg  Ile Gln Pro Pro Leu  Gly Phe Gly 
    1535                 1540                 1545             


Lys Leu  Cys Pro His Arg Val  Ala Cys Lys Arg Leu  Val Ser Met 
    1550                 1555                 1560             


Asn Met  Pro Leu Asn Ser Asp  Gly Xaa Val Met Phe  Asn Ala Xaa 
    1565                 1570                 1575             


Leu Phe  Ala Leu Val Arg Xaa  Ala Leu Arg Ile Lys  Xaa Glu Gly 
    1580                 1585                 1590             


Asn Leu  Glu Gln Ala Asn Glu  Glu Leu Arg Ala Ile  Ile Lys Lys 
    1595                 1600                 1605             


Ile Trp  Lys Arg Xaa Ser Met  Lys Leu Leu Asp Gln  Val Val Pro 
    1610                 1615                 1620             


Pro Ala  Gly Asp Asp Glu Val  Xaa Val Gly Lys Phe  Tyr Ala Xaa 
    1625                 1630                 1635             


Phe Leu  Ile Gln Glu Tyr Phe  Arg Lys Phe Lys Lys  Arg Lys Glu 
    1640                 1645                 1650             


Gln Gly  Leu Val Gly Lys Pro  Ser Gln Arg Asn Ala  Leu Ser Leu 
    1655                 1660                 1665             


Gln Ala  Gly Leu Arg Xaa Leu  His Asp Ile Gly Pro  Glu Ile Arg 
    1670                 1675                 1680             


Arg Ala  Ile Ser Gly Asp Leu  Xaa Ala Glu Glu Glu  Leu Asp Lys 
    1685                 1690                 1695             


Ala Met  Lys Glu Ala Val Ser  Ala Ala Ser Glu Asp  Asp Ile Phe 
    1700                 1705                 1710             


Arg Arg  Ala Gly Gly Leu Phe  Gly Asn His Val Ser  Tyr Tyr Gln 
    1715                 1720                 1725             


Ser Asp  Gly Arg Ser Ala Phe  Pro Gln Xaa Phe Xaa  Xaa Gln Arg 
    1730                 1735                 1740             


Pro Leu  His Ile Asn Lys Ala  Gly Ser Ser Gln Gly  Asp Xaa Glu 
    1745                 1750                 1755             


Ser Pro  Ser His Glu Lys Leu  Val Asp Ser Xaa Phe  Xaa Pro Ser 
    1760                 1765                 1770             


Ser Tyr  Ser Ser Xaa Gly Ser  Asn Ala Asn Ile Asn  Asn Ala Asn 
    1775                 1780                 1785             


Asn Xaa  Ala Leu Gly Arg Leu  Pro Arg Pro Ala Gly  Tyr Pro Ser 
    1790                 1795                 1800             


Xaa Val  Ser Xaa Val Glu Gly  His Gly Pro Pro Leu  Ser Pro Ala 
    1805                 1810                 1815             


Ile Arg  Val Gln Glu Val Ala  Trp Lys Leu Ser Ser  Asn Arg Cys 
    1820                 1825                 1830             


His Ser  Arg Glu Ser Gln Ala  Ala Met Ala Gly Gln  Glu Glu Xaa 
    1835                 1840                 1845             


Ser Gln  Asp Glu Xaa Tyr Glu  Val Lys Met Asn His  Asp Xaa Glu 
    1850                 1855                 1860             


Ala Cys  Ser Glu Pro Ser Leu  Leu Ser Xaa Glu Met  Leu Ser Tyr 
    1865                 1870                 1875             


Gln Asp  Asp Glu Asn Arg Gln  Leu Xaa Leu Pro Glu  Glu Asp Lys 
    1880                 1885                 1890             


Arg Asp  Ile Arg Gln Ser Pro  Lys Arg Gly Phe Leu  Arg Ser Ala 
    1895                 1900                 1905             


Ser Leu  Gly Arg Arg Ala Ser  Phe His Leu Glu Cys  Leu Lys Arg 
    1910                 1915                 1920             


Gln Lys  Asp Arg Gly Gly Asp  Ile Ser Gln Lys Xaa  Val Leu Pro 
    1925                 1930                 1935             


Leu His  Leu Val His His Gln  Ala Leu Ala Val Ala  Gly Leu Ser 
    1940                 1945                 1950             


Pro Leu  Leu Gln Arg Ser His  Ser Pro Ala Ser Phe  Pro Arg Pro 
    1955                 1960                 1965             


Phe Ala  Xaa Pro Pro Ala Xaa  Pro Gly Ser Arg Gly  Trp Pro Pro 
    1970                 1975                 1980             


Gln Pro  Val Pro Xaa Leu Arg  Leu Glu Gly Val Glu  Ser Ser Glu 
    1985                 1990                 1995             


Lys Leu  Asn Ser Ser Phe Pro  Ser Ile His Cys Gly  Ser Trp Ala 
    2000                 2005                 2010             


Glu Xaa  Xaa Pro Gly Gly Gly  Gly Ser Ser Ala Ala  Arg Arg Val 
    2015                 2020                 2025             


Arg Pro  Val Ser Leu Met Val  Pro Ser Gln Ala Gly  Ala Pro Gly 
    2030                 2035                 2040             


Arg Gln  Phe His Gly Ser Ala  Ser Ser Leu Val Glu  Ala Val Leu 
    2045                 2050                 2055             


Ile Ser  Glu Gly Leu Gly Gln  Phe Ala Gln Asp Pro  Lys Phe Ile 
    2060                 2065                 2070             


Glu Val  Xaa Xaa Gln Glu Leu  Ala Asp Ala Cys Asp  Met Xaa Ile 
    2075                 2080                 2085             


Glu Glu  Met Glu Ser Ala Ala  Asp Asn Ile Leu Ser  Gly Gly Ala 
    2090                 2095                 2100             


Pro Gln  Ser Pro Asn Gly Ala  Leu Leu Pro Phe Val  Asn Cys Arg 
    2105                 2110                 2115             


Asp Ala  Gly Gln Asp Arg Ala  Gly Gly Glu Glu Asp  Ala Gly Cys 
    2120                 2125                 2130             


Val Arg  Ala Arg Gly Arg Pro  Ser Glu Glu Glu Leu  Gln Asp Ser 
    2135                 2140                 2145             


Arg Val  Tyr Val Ser Ser Leu  
    2150                 2155 


<210> 4663
<211> 2157
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1561)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1615)..(1615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1676)..(1676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1693)..(1693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1742)..(1743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1759)..(1759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1771)..(1771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1780)..(1780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1792)..(1792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1806)..(1806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1809)..(1809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1850)..(1850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1855)..(1855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1864)..(1864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1875)..(1875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1889)..(1889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1937)..(1937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1973)..(1973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1977)..(1977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1990)..(1990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2017)..(2018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2078)..(2079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2089)..(2089)
<223> Selenocysteine

<400> 4663
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Xaa Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Xaa Xaa Ile Phe 
    930                 935                 940                 


Xaa Ile Glu Ile Ala Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Xaa  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Xaa Glu Val Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Xaa Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Xaa Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Xaa Leu Leu  Trp Xaa Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Xaa  Xaa Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Xaa Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Xaa Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Xaa Glu Gly 
    1430                 1435                 1440             


Glu Xaa  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Xaa Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Xaa Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Xaa  Val Met Phe Asn Ala  Xaa Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Xaa Ala Leu  Arg Ile Lys Xaa Glu  Glu Gly Pro 
    1565                 1570                 1575             


Ser Pro  Ser Glu Ala His Gln  Gly Ala Glu Asp Pro  Phe Arg Pro 
    1580                 1585                 1590             


Ala Gly  Asn Leu Glu Gln Ala  Asn Glu Glu Leu Arg  Ala Ile Ile 
    1595                 1600                 1605             


Lys Lys  Ile Trp Lys Arg Xaa  Ser Met Lys Leu Leu  Asp Gln Val 
    1610                 1615                 1620             


Val Pro  Pro Ala Gly Asp Asp  Glu Val Xaa Val Gly  Lys Phe Tyr 
    1625                 1630                 1635             


Ala Xaa  Phe Leu Ile Gln Glu  Tyr Phe Arg Lys Phe  Lys Lys Arg 
    1640                 1645                 1650             


Lys Glu  Gln Gly Leu Val Gly  Lys Pro Ser Gln Arg  Asn Ala Leu 
    1655                 1660                 1665             


Ser Leu  Gln Ala Gly Leu Arg  Xaa Leu His Asp Ile  Gly Pro Glu 
    1670                 1675                 1680             


Ile Arg  Arg Ala Ile Ser Gly  Asp Leu Xaa Ala Glu  Glu Glu Leu 
    1685                 1690                 1695             


Asp Lys  Ala Met Lys Glu Ala  Val Ser Ala Ala Ser  Glu Asp Asp 
    1700                 1705                 1710             


Ile Phe  Arg Arg Ala Gly Gly  Leu Phe Gly Asn His  Val Ser Tyr 
    1715                 1720                 1725             


Tyr Gln  Ser Asp Gly Arg Ser  Ala Phe Pro Gln Xaa  Phe Xaa Xaa 
    1730                 1735                 1740             


Gln Arg  Pro Leu His Ile Asn  Lys Ala Gly Ser Ser  Gln Gly Asp 
    1745                 1750                 1755             


Xaa Glu  Ser Pro Ser His Glu  Lys Leu Val Asp Ser  Xaa Phe Xaa 
    1760                 1765                 1770             


Pro Ser  Ser Tyr Ser Ser Xaa  Gly Ser Asn Ala Asn  Ile Asn Asn 
    1775                 1780                 1785             


Ala Asn  Asn Xaa Ala Leu Gly  Arg Leu Pro Arg Pro  Ala Gly Tyr 
    1790                 1795                 1800             


Pro Ser  Xaa Val Ser Xaa Val  Glu Gly His Gly Pro  Pro Leu Ser 
    1805                 1810                 1815             


Pro Ala  Ile Arg Val Gln Glu  Val Ala Trp Lys Leu  Ser Ser Asn 
    1820                 1825                 1830             


Arg Cys  His Ser Arg Glu Ser  Gln Ala Ala Met Ala  Gly Gln Glu 
    1835                 1840                 1845             


Glu Xaa  Ser Gln Asp Glu Xaa  Tyr Glu Val Lys Met  Asn His Asp 
    1850                 1855                 1860             


Xaa Glu  Ala Cys Ser Glu Pro  Ser Leu Leu Ser Xaa  Glu Met Leu 
    1865                 1870                 1875             


Ser Tyr  Gln Asp Asp Glu Asn  Arg Gln Leu Xaa Leu  Pro Glu Glu 
    1880                 1885                 1890             


Asp Lys  Arg Asp Ile Arg Gln  Ser Pro Lys Arg Gly  Phe Leu Arg 
    1895                 1900                 1905             


Ser Ala  Ser Leu Gly Arg Arg  Ala Ser Phe His Leu  Glu Cys Leu 
    1910                 1915                 1920             


Lys Arg  Gln Lys Asp Arg Gly  Gly Asp Ile Ser Gln  Lys Xaa Val 
    1925                 1930                 1935             


Leu Pro  Leu His Leu Val His  His Gln Ala Leu Ala  Val Ala Gly 
    1940                 1945                 1950             


Leu Ser  Pro Leu Leu Gln Arg  Ser His Ser Pro Ala  Ser Phe Pro 
    1955                 1960                 1965             


Arg Pro  Phe Ala Xaa Pro Pro  Ala Xaa Pro Gly Ser  Arg Gly Trp 
    1970                 1975                 1980             


Pro Pro  Gln Pro Val Pro Xaa  Leu Arg Leu Glu Gly  Val Glu Ser 
    1985                 1990                 1995             


Ser Glu  Lys Leu Asn Ser Ser  Phe Pro Ser Ile His  Cys Gly Ser 
    2000                 2005                 2010             


Trp Ala  Glu Xaa Xaa Pro Gly  Gly Gly Gly Ser Ser  Ala Ala Arg 
    2015                 2020                 2025             


Arg Val  Arg Pro Val Ser Leu  Met Val Pro Ser Gln  Ala Gly Ala 
    2030                 2035                 2040             


Pro Gly  Arg Gln Phe His Gly  Ser Ala Ser Ser Leu  Val Glu Ala 
    2045                 2050                 2055             


Val Leu  Ile Ser Glu Gly Leu  Gly Gln Phe Ala Gln  Asp Pro Lys 
    2060                 2065                 2070             


Phe Ile  Glu Val Xaa Xaa Gln  Glu Leu Ala Asp Ala  Cys Asp Met 
    2075                 2080                 2085             


Xaa Ile  Glu Glu Met Glu Ser  Ala Ala Asp Asn Ile  Leu Ser Gly 
    2090                 2095                 2100             


Gly Ala  Pro Gln Ser Pro Asn  Gly Ala Leu Leu Pro  Phe Val Asn 
    2105                 2110                 2115             


Cys Arg  Asp Ala Gly Gln Asp  Arg Ala Gly Gly Glu  Glu Asp Ala 
    2120                 2125                 2130             


Gly Cys  Val Arg Ala Arg Gly  Arg Pro Ser Glu Glu  Glu Leu Gln 
    2135                 2140                 2145             


Asp Ser  Arg Val Tyr Val Ser  Ser Leu 
    2150                 2155         


<210> 4664
<211> 2157
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1561)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1615)..(1615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1676)..(1676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1693)..(1693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1742)..(1743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1759)..(1759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1771)..(1771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1780)..(1780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1792)..(1792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1806)..(1806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1809)..(1809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1850)..(1850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1855)..(1855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1864)..(1864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1875)..(1875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1889)..(1889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1937)..(1937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1973)..(1973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1977)..(1977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1990)..(1990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2017)..(2018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2078)..(2079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2089)..(2089)
<223> Selenocysteine

<400> 4664
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Xaa Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Gly Asn Ala Asp Tyr Val Phe Xaa Ser Ile Phe 
    930                 935                 940                 


Xaa Leu Glu Ile Ile Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Xaa  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Xaa Glu Val Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Xaa Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Xaa Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Xaa Leu Leu  Trp Xaa Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Xaa  Xaa Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Xaa Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Xaa Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Xaa Glu Gly 
    1430                 1435                 1440             


Glu Xaa  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Xaa Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Xaa Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Xaa  Val Met Phe Asn Ala  Xaa Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Xaa Ala Leu  Arg Ile Lys Xaa Glu  Glu Gly Pro 
    1565                 1570                 1575             


Ser Pro  Ser Glu Ala His Gln  Gly Ala Glu Asp Pro  Phe Arg Pro 
    1580                 1585                 1590             


Ala Gly  Asn Leu Glu Gln Ala  Asn Glu Glu Leu Arg  Ala Ile Ile 
    1595                 1600                 1605             


Lys Lys  Ile Trp Lys Arg Xaa  Ser Met Lys Leu Leu  Asp Gln Val 
    1610                 1615                 1620             


Val Pro  Pro Ala Gly Asp Asp  Glu Val Xaa Val Gly  Lys Phe Tyr 
    1625                 1630                 1635             


Ala Xaa  Phe Leu Ile Gln Glu  Tyr Phe Arg Lys Phe  Lys Lys Arg 
    1640                 1645                 1650             


Lys Glu  Gln Gly Leu Val Gly  Lys Pro Ser Gln Arg  Asn Ala Leu 
    1655                 1660                 1665             


Ser Leu  Gln Ala Gly Leu Arg  Xaa Leu His Asp Ile  Gly Pro Glu 
    1670                 1675                 1680             


Ile Arg  Arg Ala Ile Ser Gly  Asp Leu Xaa Ala Glu  Glu Glu Leu 
    1685                 1690                 1695             


Asp Lys  Ala Met Lys Glu Ala  Val Ser Ala Ala Ser  Glu Asp Asp 
    1700                 1705                 1710             


Ile Phe  Arg Arg Ala Gly Gly  Leu Phe Gly Asn His  Val Ser Tyr 
    1715                 1720                 1725             


Tyr Gln  Ser Asp Gly Arg Ser  Ala Phe Pro Gln Xaa  Phe Xaa Xaa 
    1730                 1735                 1740             


Gln Arg  Pro Leu His Ile Asn  Lys Ala Gly Ser Ser  Gln Gly Asp 
    1745                 1750                 1755             


Xaa Glu  Ser Pro Ser His Glu  Lys Leu Val Asp Ser  Xaa Phe Xaa 
    1760                 1765                 1770             


Pro Ser  Ser Tyr Ser Ser Xaa  Gly Ser Asn Ala Asn  Ile Asn Asn 
    1775                 1780                 1785             


Ala Asn  Asn Xaa Ala Leu Gly  Arg Leu Pro Arg Pro  Ala Gly Tyr 
    1790                 1795                 1800             


Pro Ser  Xaa Val Ser Xaa Val  Glu Gly His Gly Pro  Pro Leu Ser 
    1805                 1810                 1815             


Pro Ala  Ile Arg Val Gln Glu  Val Ala Trp Lys Leu  Ser Ser Asn 
    1820                 1825                 1830             


Arg Cys  His Ser Arg Glu Ser  Gln Ala Ala Met Ala  Gly Gln Glu 
    1835                 1840                 1845             


Glu Xaa  Ser Gln Asp Glu Xaa  Tyr Glu Val Lys Met  Asn His Asp 
    1850                 1855                 1860             


Xaa Glu  Ala Cys Ser Glu Pro  Ser Leu Leu Ser Xaa  Glu Met Leu 
    1865                 1870                 1875             


Ser Tyr  Gln Asp Asp Glu Asn  Arg Gln Leu Xaa Leu  Pro Glu Glu 
    1880                 1885                 1890             


Asp Lys  Arg Asp Ile Arg Gln  Ser Pro Lys Arg Gly  Phe Leu Arg 
    1895                 1900                 1905             


Ser Ala  Ser Leu Gly Arg Arg  Ala Ser Phe His Leu  Glu Cys Leu 
    1910                 1915                 1920             


Lys Arg  Gln Lys Asp Arg Gly  Gly Asp Ile Ser Gln  Lys Xaa Val 
    1925                 1930                 1935             


Leu Pro  Leu His Leu Val His  His Gln Ala Leu Ala  Val Ala Gly 
    1940                 1945                 1950             


Leu Ser  Pro Leu Leu Gln Arg  Ser His Ser Pro Ala  Ser Phe Pro 
    1955                 1960                 1965             


Arg Pro  Phe Ala Xaa Pro Pro  Ala Xaa Pro Gly Ser  Arg Gly Trp 
    1970                 1975                 1980             


Pro Pro  Gln Pro Val Pro Xaa  Leu Arg Leu Glu Gly  Val Glu Ser 
    1985                 1990                 1995             


Ser Glu  Lys Leu Asn Ser Ser  Phe Pro Ser Ile His  Cys Gly Ser 
    2000                 2005                 2010             


Trp Ala  Glu Xaa Xaa Pro Gly  Gly Gly Gly Ser Ser  Ala Ala Arg 
    2015                 2020                 2025             


Arg Val  Arg Pro Val Ser Leu  Met Val Pro Ser Gln  Ala Gly Ala 
    2030                 2035                 2040             


Pro Gly  Arg Gln Phe His Gly  Ser Ala Ser Ser Leu  Val Glu Ala 
    2045                 2050                 2055             


Val Leu  Ile Ser Glu Gly Leu  Gly Gln Phe Ala Gln  Asp Pro Lys 
    2060                 2065                 2070             


Phe Ile  Glu Val Xaa Xaa Gln  Glu Leu Ala Asp Ala  Cys Asp Met 
    2075                 2080                 2085             


Xaa Ile  Glu Glu Met Glu Ser  Ala Ala Asp Asn Ile  Leu Ser Gly 
    2090                 2095                 2100             


Gly Ala  Pro Gln Ser Pro Asn  Gly Ala Leu Leu Pro  Phe Val Asn 
    2105                 2110                 2115             


Cys Arg  Asp Ala Gly Gln Asp  Arg Ala Gly Gly Glu  Glu Asp Ala 
    2120                 2125                 2130             


Gly Cys  Val Arg Ala Arg Gly  Arg Pro Ser Glu Glu  Glu Leu Gln 
    2135                 2140                 2145             


Asp Ser  Arg Val Tyr Val Ser  Ser Leu 
    2150                 2155         


<210> 4665
<211> 2157
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1561)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1615)..(1615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1676)..(1676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1693)..(1693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1742)..(1743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1759)..(1759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1771)..(1771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1780)..(1780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1792)..(1792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1806)..(1806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1809)..(1809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1850)..(1850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1855)..(1855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1864)..(1864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1875)..(1875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1889)..(1889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1937)..(1937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1973)..(1973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1977)..(1977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1990)..(1990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2017)..(2018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2078)..(2079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2089)..(2089)
<223> Selenocysteine

<400> 4665
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Xaa Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Xaa Xaa Ile Phe 
    930                 935                 940                 


Xaa Ile Glu Ile Ala Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys Gly Tyr 
    1265                 1270                 1275             


Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe Leu Ile  Val Ile Gly 
    1280                 1285                 1290             


Ser Ile  Ile Asp Val Ile Leu  Ser Glu Xaa Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Xaa Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Xaa Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Xaa Leu Leu  Trp Xaa Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Xaa  Xaa Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Xaa Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Xaa Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Xaa Glu Gly 
    1430                 1435                 1440             


Glu Xaa  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Xaa Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Xaa Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Xaa  Val Met Phe Asn Ala  Xaa Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Xaa Ala Leu  Arg Ile Lys Xaa Glu  Glu Gly Pro 
    1565                 1570                 1575             


Ser Pro  Ser Glu Ala His Gln  Gly Ala Glu Asp Pro  Phe Arg Pro 
    1580                 1585                 1590             


Ala Gly  Asn Leu Glu Gln Ala  Asn Glu Glu Leu Arg  Ala Ile Ile 
    1595                 1600                 1605             


Lys Lys  Ile Trp Lys Arg Xaa  Ser Met Lys Leu Leu  Asp Gln Val 
    1610                 1615                 1620             


Val Pro  Pro Ala Gly Asp Asp  Glu Val Xaa Val Gly  Lys Phe Tyr 
    1625                 1630                 1635             


Ala Xaa  Phe Leu Ile Gln Glu  Tyr Phe Arg Lys Phe  Lys Lys Arg 
    1640                 1645                 1650             


Lys Glu  Gln Gly Leu Val Gly  Lys Pro Ser Gln Arg  Asn Ala Leu 
    1655                 1660                 1665             


Ser Leu  Gln Ala Gly Leu Arg  Xaa Leu His Asp Ile  Gly Pro Glu 
    1670                 1675                 1680             


Ile Arg  Arg Ala Ile Ser Gly  Asp Leu Xaa Ala Glu  Glu Glu Leu 
    1685                 1690                 1695             


Asp Lys  Ala Met Lys Glu Ala  Val Ser Ala Ala Ser  Glu Asp Asp 
    1700                 1705                 1710             


Ile Phe  Arg Arg Ala Gly Gly  Leu Phe Gly Asn His  Val Ser Tyr 
    1715                 1720                 1725             


Tyr Gln  Ser Asp Gly Arg Ser  Ala Phe Pro Gln Xaa  Phe Xaa Xaa 
    1730                 1735                 1740             


Gln Arg  Pro Leu His Ile Asn  Lys Ala Gly Ser Ser  Gln Gly Asp 
    1745                 1750                 1755             


Xaa Glu  Ser Pro Ser His Glu  Lys Leu Val Asp Ser  Xaa Phe Xaa 
    1760                 1765                 1770             


Pro Ser  Ser Tyr Ser Ser Xaa  Gly Ser Asn Ala Asn  Ile Asn Asn 
    1775                 1780                 1785             


Ala Asn  Asn Xaa Ala Leu Gly  Arg Leu Pro Arg Pro  Ala Gly Tyr 
    1790                 1795                 1800             


Pro Ser  Xaa Val Ser Xaa Val  Glu Gly His Gly Pro  Pro Leu Ser 
    1805                 1810                 1815             


Pro Ala  Ile Arg Val Gln Glu  Val Ala Trp Lys Leu  Ser Ser Asn 
    1820                 1825                 1830             


Arg Cys  His Ser Arg Glu Ser  Gln Ala Ala Met Ala  Gly Gln Glu 
    1835                 1840                 1845             


Glu Xaa  Ser Gln Asp Glu Xaa  Tyr Glu Val Lys Met  Asn His Asp 
    1850                 1855                 1860             


Xaa Glu  Ala Cys Ser Glu Pro  Ser Leu Leu Ser Xaa  Glu Met Leu 
    1865                 1870                 1875             


Ser Tyr  Gln Asp Asp Glu Asn  Arg Gln Leu Xaa Leu  Pro Glu Glu 
    1880                 1885                 1890             


Asp Lys  Arg Asp Ile Arg Gln  Ser Pro Lys Arg Gly  Phe Leu Arg 
    1895                 1900                 1905             


Ser Ala  Ser Leu Gly Arg Arg  Ala Ser Phe His Leu  Glu Cys Leu 
    1910                 1915                 1920             


Lys Arg  Gln Lys Asp Arg Gly  Gly Asp Ile Ser Gln  Lys Xaa Val 
    1925                 1930                 1935             


Leu Pro  Leu His Leu Val His  His Gln Ala Leu Ala  Val Ala Gly 
    1940                 1945                 1950             


Leu Ser  Pro Leu Leu Gln Arg  Ser His Ser Pro Ala  Ser Phe Pro 
    1955                 1960                 1965             


Arg Pro  Phe Ala Xaa Pro Pro  Ala Xaa Pro Gly Ser  Arg Gly Trp 
    1970                 1975                 1980             


Pro Pro  Gln Pro Val Pro Xaa  Leu Arg Leu Glu Gly  Val Glu Ser 
    1985                 1990                 1995             


Ser Glu  Lys Leu Asn Ser Ser  Phe Pro Ser Ile His  Cys Gly Ser 
    2000                 2005                 2010             


Trp Ala  Glu Xaa Xaa Pro Gly  Gly Gly Gly Ser Ser  Ala Ala Arg 
    2015                 2020                 2025             


Arg Val  Arg Pro Val Ser Leu  Met Val Pro Ser Gln  Ala Gly Ala 
    2030                 2035                 2040             


Pro Gly  Arg Gln Phe His Gly  Ser Ala Ser Ser Leu  Val Glu Ala 
    2045                 2050                 2055             


Val Leu  Ile Ser Glu Gly Leu  Gly Gln Phe Ala Gln  Asp Pro Lys 
    2060                 2065                 2070             


Phe Ile  Glu Val Xaa Xaa Gln  Glu Leu Ala Asp Ala  Cys Asp Met 
    2075                 2080                 2085             


Xaa Ile  Glu Glu Met Glu Ser  Ala Ala Asp Asn Ile  Leu Ser Gly 
    2090                 2095                 2100             


Gly Ala  Pro Gln Ser Pro Asn  Gly Ala Leu Leu Pro  Phe Val Asn 
    2105                 2110                 2115             


Cys Arg  Asp Ala Gly Gln Asp  Arg Ala Gly Gly Glu  Glu Asp Ala 
    2120                 2125                 2130             


Gly Cys  Val Arg Ala Arg Gly  Arg Pro Ser Glu Glu  Glu Leu Gln 
    2135                 2140                 2145             


Asp Ser  Arg Val Tyr Val Ser  Ser Leu 
    2150                 2155         


<210> 4666
<211> 2158
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1253)..(1253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1321)..(1321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1346)..(1346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1368)..(1368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1372)..(1372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1410)..(1411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1421)..(1421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1461)..(1461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1465)..(1465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1503)..(1503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1539)..(1539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1575)..(1575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1581)..(1581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1588)..(1588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1616)..(1616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1634)..(1634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1641)..(1641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1677)..(1677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1694)..(1694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1741)..(1741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1743)..(1744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1772)..(1772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1774)..(1774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1781)..(1781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1793)..(1793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1807)..(1807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1810)..(1810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1851)..(1851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1856)..(1856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1865)..(1865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1876)..(1876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1890)..(1890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1938)..(1938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1974)..(1974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1978)..(1978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1991)..(1991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2018)..(2019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2079)..(2080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2090)..(2090)
<223> Selenocysteine

<400> 4666
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Xaa Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Xaa Xaa Ile Phe 
    930                 935                 940                 


Xaa Ile Glu Ile Ala Leu Lys Ile Leu Gly Asn Ala Asp Tyr Val Phe 
945                 950                 955                 960 


Xaa Ser Ile Phe Xaa Leu Glu Ile Ile Leu Lys Met Xaa Ala Tyr Gly 
                965                 970                 975     


Ala Phe Leu His Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu 
            980                 985                 990         


Asp Leu Leu Val Val Ser Val Ser  Leu Ile Ser Phe Gly  Ile Gln Ser 
        995                 1000                 1005             


Ser Ala  Ile Asn Val Val Lys  Ile Leu Arg Val Leu  Arg Val Leu 
    1010                 1015                 1020             


Arg Pro  Leu Arg Ala Ile Asn  Arg Ala Lys Gly Leu  Lys His Val 
    1025                 1030                 1035             


Val Gln  Cys Val Phe Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val 
    1040                 1045                 1050             


Ile Val  Xaa Xaa Leu Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val 
    1055                 1060                 1065             


Gln Leu  Phe Lys Gly Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys 
    1070                 1075                 1080             


Gln Xaa  Glu Ala Glu Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp 
    1085                 1090                 1095             


Gly Glu  Val Asp His Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn 
    1100                 1105                 1110             


Ser Lys  Phe Asp Phe Asp Asn  Val Leu Ala Ala Met  Met Ala Leu 
    1115                 1120                 1125             


Phe Xaa  Val Ser Xaa Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg 
    1130                 1135                 1140             


Ser Ile  Asp Ser His Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr 
    1145                 1150                 1155             


Arg Val  Glu Ile Ser Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile 
    1160                 1165                 1170             


Ala Phe  Phe Met Met Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa 
    1175                 1180                 1185             


Phe Gln  Glu Gln Gly Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp 
    1190                 1195                 1200             


Lys Asn  Gln Arg Gln Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro 
    1205                 1210                 1215             


Leu Arg  Arg Tyr Ile Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp 
    1220                 1225                 1230             


Tyr Val  Val Asn Ser Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu 
    1235                 1240                 1245             


Ile Leu  Leu Asn Xaa Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln 
    1250                 1255                 1260             


Ser Cys  Leu Phe Lys Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe 
    1265                 1270                 1275             


Xaa Gly  Leu Phe Xaa Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe 
    1280                 1285                 1290             


Lys Pro  Lys His Tyr Phe Cys  Asp Ala Trp Asn Xaa  Phe Asp Ala 
    1295                 1300                 1305             


Leu Ile  Val Val Gly Ser Ile  Val Asp Ile Ala Ile  Xaa Glu Val 
    1310                 1315                 1320             


Asn Pro  Ala Glu His Xaa Gln  Cys Ser Pro Ser Met  Asn Ala Glu 
    1325                 1330                 1335             


Glu Asn  Ser Arg Ile Ser Ile  Xaa Phe Phe Arg Leu  Phe Arg Val 
    1340                 1345                 1350             


Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Xaa 
    1355                 1360                 1365             


Leu Leu  Trp Xaa Phe Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val 
    1370                 1375                 1380             


Ala Leu  Leu Ile Val Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly 
    1385                 1390                 1395             


Met Gln  Val Phe Gly Lys Ile  Ala Leu Asn Asp Xaa  Xaa Glu Ile 
    1400                 1405                 1410             


Asn Arg  Asn Asn Asn Phe Gln  Xaa Phe Pro Gln Ala  Val Leu Leu 
    1415                 1420                 1425             


Leu Phe  Arg Cys Ala Xaa Gly  Glu Ala Trp Gln Asp  Ile Met Leu 
    1430                 1435                 1440             


Ala Cys  Met Pro Gly Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser 
    1445                 1450                 1455             


Asn Ser  Xaa Glu Gly Glu Xaa  Pro Cys Gly Ser Ser  Phe Ala Val 
    1460                 1465                 1470             


Phe Tyr  Phe Ile Ser Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile 
    1475                 1480                 1485             


Asn Leu  Phe Val Ala Val Ile  Met Asp Asn Phe Asp  Tyr Leu Xaa 
    1490                 1495                 1500             


Arg Asp  Trp Ser Ile Leu Gly  Pro His His Leu Asp  Glu Phe Lys 
    1505                 1510                 1515             


Arg Ile  Trp Ala Glu Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys 
    1520                 1525                 1530             


His Leu  Asp Val Val Xaa Leu  Leu Arg Arg Ile Gln  Pro Pro Leu 
    1535                 1540                 1545             


Gly Phe  Gly Lys Leu Cys Pro  His Arg Val Ala Cys  Lys Arg Leu 
    1550                 1555                 1560             


Val Ser  Met Asn Met Pro Leu  Asn Ser Asp Gly Xaa  Val Met Phe 
    1565                 1570                 1575             


Asn Ala  Xaa Leu Phe Ala Leu  Val Arg Xaa Ala Leu  Arg Ile Lys 
    1580                 1585                 1590             


Xaa Glu  Gly Asn Leu Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile 
    1595                 1600                 1605             


Ile Lys  Lys Ile Trp Lys Arg  Xaa Ser Met Lys Leu  Leu Asp Gln 
    1610                 1615                 1620             


Val Val  Pro Pro Ala Gly Asp  Asp Glu Val Xaa Val  Gly Lys Phe 
    1625                 1630                 1635             


Tyr Ala  Xaa Phe Leu Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys 
    1640                 1645                 1650             


Arg Lys  Glu Gln Gly Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala 
    1655                 1660                 1665             


Leu Ser  Leu Gln Ala Gly Leu  Arg Xaa Leu His Asp  Ile Gly Pro 
    1670                 1675                 1680             


Glu Ile  Arg Arg Ala Ile Ser  Gly Asp Leu Xaa Ala  Glu Glu Glu 
    1685                 1690                 1695             


Leu Asp  Lys Ala Met Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp 
    1700                 1705                 1710             


Asp Ile  Phe Arg Arg Ala Gly  Gly Leu Phe Gly Asn  His Val Ser 
    1715                 1720                 1725             


Tyr Tyr  Gln Ser Asp Gly Arg  Ser Ala Phe Pro Gln  Xaa Phe Xaa 
    1730                 1735                 1740             


Xaa Gln  Arg Pro Leu His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly 
    1745                 1750                 1755             


Asp Xaa  Glu Ser Pro Ser His  Glu Lys Leu Val Asp  Ser Xaa Phe 
    1760                 1765                 1770             


Xaa Pro  Ser Ser Tyr Ser Ser  Xaa Gly Ser Asn Ala  Asn Ile Asn 
    1775                 1780                 1785             


Asn Ala  Asn Asn Xaa Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly 
    1790                 1795                 1800             


Tyr Pro  Ser Xaa Val Ser Xaa  Val Glu Gly His Gly  Pro Pro Leu 
    1805                 1810                 1815             


Ser Pro  Ala Ile Arg Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser 
    1820                 1825                 1830             


Asn Arg  Cys His Ser Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln 
    1835                 1840                 1845             


Glu Glu  Xaa Ser Gln Asp Glu  Xaa Tyr Glu Val Lys  Met Asn His 
    1850                 1855                 1860             


Asp Xaa  Glu Ala Cys Ser Glu  Pro Ser Leu Leu Ser  Xaa Glu Met 
    1865                 1870                 1875             


Leu Ser  Tyr Gln Asp Asp Glu  Asn Arg Gln Leu Xaa  Leu Pro Glu 
    1880                 1885                 1890             


Glu Asp  Lys Arg Asp Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu 
    1895                 1900                 1905             


Arg Ser  Ala Ser Leu Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys 
    1910                 1915                 1920             


Leu Lys  Arg Gln Lys Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Xaa 
    1925                 1930                 1935             


Val Leu  Pro Leu His Leu Val  His His Gln Ala Leu  Ala Val Ala 
    1940                 1945                 1950             


Gly Leu  Ser Pro Leu Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe 
    1955                 1960                 1965             


Pro Arg  Pro Phe Ala Xaa Pro  Pro Ala Xaa Pro Gly  Ser Arg Gly 
    1970                 1975                 1980             


Trp Pro  Pro Gln Pro Val Pro  Xaa Leu Arg Leu Glu  Gly Val Glu 
    1985                 1990                 1995             


Ser Ser  Glu Lys Leu Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly 
    2000                 2005                 2010             


Ser Trp  Ala Glu Xaa Xaa Pro  Gly Gly Gly Gly Ser  Ser Ala Ala 
    2015                 2020                 2025             


Arg Arg  Val Arg Pro Val Ser  Leu Met Val Pro Ser  Gln Ala Gly 
    2030                 2035                 2040             


Ala Pro  Gly Arg Gln Phe His  Gly Ser Ala Ser Ser  Leu Val Glu 
    2045                 2050                 2055             


Ala Val  Leu Ile Ser Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro 
    2060                 2065                 2070             


Lys Phe  Ile Glu Val Xaa Xaa  Gln Glu Leu Ala Asp  Ala Cys Asp 
    2075                 2080                 2085             


Met Xaa  Ile Glu Glu Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser 
    2090                 2095                 2100             


Gly Gly  Ala Pro Gln Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val 
    2105                 2110                 2115             


Asn Cys  Arg Asp Ala Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp 
    2120                 2125                 2130             


Ala Gly  Cys Val Arg Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu 
    2135                 2140                 2145             


Gln Asp  Ser Arg Val Tyr Val  Ser Ser Leu 
    2150                 2155             


<210> 4667
<211> 2163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1138)..(1138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1193)..(1193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1244)..(1244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1377)..(1377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1415)..(1416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1426)..(1426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1439)..(1439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1466)..(1466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1470)..(1470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1508)..(1508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1544)..(1544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1580)..(1580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1593)..(1593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1599)..(1599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1639)..(1639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1682)..(1682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1699)..(1699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1746)..(1746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1748)..(1749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1765)..(1765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1777)..(1777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1779)..(1779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1786)..(1786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1798)..(1798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1812)..(1812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1815)..(1815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1856)..(1856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1861)..(1861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1870)..(1870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1881)..(1881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1895)..(1895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1943)..(1943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1979)..(1979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1983)..(1983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1996)..(1996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2023)..(2024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2084)..(2085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2095)..(2095)
<223> Selenocysteine

<400> 4667
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Xaa Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Arg 
    450                 455                 460                 


Gly Xaa Pro Ala Gly Met Leu Asp Gln Lys Lys Gly Lys Phe Ala Trp 
465                 470                 475                 480 


Phe Ser His Ser Xaa Glu Xaa His Val Ser Met Pro Xaa Ser Glu Xaa 
                485                 490                 495     


Glu Ser Val Asn Xaa Glu Asn Val Ala Gly Gly Asp Ile Glu Gly Glu 
            500                 505                 510         


Asn Cys Gly Ala Arg Leu Ala His Arg Ile Ser Lys Ser Lys Phe Ser 
        515                 520                 525             


Arg Tyr Trp Arg Arg Trp Asn Arg Phe Cys Arg Arg Lys Cys Arg Ala 
    530                 535                 540                 


Ala Val Lys Ser Asn Val Phe Tyr Trp Leu Val Ile Phe Leu Val Phe 
545                 550                 555                 560 


Leu Asn Xaa Leu Xaa Ile Ala Ser Glu His Tyr Asn Gln Pro Asn Trp 
                565                 570                 575     


Leu Xaa Glu Val Gln Asp Xaa Ala Asn Lys Ala Leu Leu Ala Leu Phe 
            580                 585                 590         


Xaa Ala Glu Met Leu Leu Lys Met Tyr Ser Leu Gly Leu Gln Ala Tyr 
        595                 600                 605             


Phe Val Ser Leu Phe Asn Arg Phe Asp Cys Phe Val Val Cys Gly Gly 
    610                 615                 620                 


Ile Leu Glu Xaa Ile Leu Val Glu Xaa Lys Ile Met Ser Pro Leu Gly 
625                 630                 635                 640 


Ile Ser Val Leu Arg Cys Val Arg Leu Leu Arg Ile Phe Lys Ile Xaa 
                645                 650                 655     


Arg Tyr Trp Asn Ser Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser 
            660                 665                 670         


Val Arg Ser Ile Ala Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile 
        675                 680                 685             


Ile Phe Ser Leu Leu Gly Met Gln Leu Phe Gly Gly Lys Phe Asn Phe 
    690                 695                 700                 


Asp Glu Met Gln Xaa Arg Arg Ser Xaa Phe Asp Asn Phe Pro Gln Ser 
705                 710                 715                 720 


Leu Leu Xaa Val Phe Gln Ile Leu Xaa Gly Glu Asp Trp Asn Ser Val 
                725                 730                 735     


Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly Pro Ser Phe Pro Gly Met 
            740                 745                 750         


Leu Val Cys Ile Tyr Phe Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile 
        755                 760                 765             


Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asp Ala 
    770                 775                 780                 


Glu Ser Leu Xaa Ser Ala Gln Lys Glu Glu Glu Glu Glu Lys Glu Arg 
785                 790                 795                 800 


Lys Lys Leu Ala Arg Xaa Ala Ser Pro Glu Lys Lys Gln Glu Leu Val 
                805                 810                 815     


Glu Lys Pro Ala Val Gly Glu Ser Lys Glu Glu Lys Ile Glu Leu Lys 
            820                 825                 830         


Ser Ile Xaa Ala Asp Gly Glu Ser Pro Pro Ala Xaa Lys Ile Asn Met 
        835                 840                 845             


Asp Asp Leu Gln Pro Asn Glu Asn Glu Asp Lys Ser Pro Tyr Pro Asn 
    850                 855                 860                 


Pro Glu Xaa Xaa Gly Glu Glu Asp Glu Glu Glu Pro Glu Met Pro Val 
865                 870                 875                 880 


Gly Pro Arg Pro Arg Pro Leu Ser Glu Leu His Leu Lys Glu Lys Ala 
                885                 890                 895     


Val Pro Met Pro Glu Ala Ser Ala Phe Phe Ile Phe Ser Ser Asn Asn 
            900                 905                 910         


Arg Phe Arg Leu Gln Cys His Arg Ile Val Asn Asp Xaa Ile Phe Xaa 
        915                 920                 925             


Asn Leu Ile Leu Phe Phe Ile Leu Leu Ser Ser Ile Ser Leu Ala Ala 
    930                 935                 940                 


Glu Asp Pro Val Gln His Xaa Ser Phe Arg Asn His Ile Leu Phe Tyr 
945                 950                 955                 960 


Phe Asp Ile Val Phe Xaa Xaa Ile Phe Xaa Ile Glu Ile Ala Leu Lys 
                965                 970                 975     


Met Xaa Ala Tyr Gly Ala Phe Leu His Lys Gly Ser Phe Cys Arg Asn 
            980                 985                 990         


Tyr Phe Asn Ile Leu Asp Leu Leu  Val Val Ser Val Ser  Leu Ile Ser 
        995                 1000                 1005             


Phe Gly  Ile Gln Ser Ser Ala  Ile Asn Val Val Lys  Ile Leu Arg 
    1010                 1015                 1020             


Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala Ile Asn  Arg Ala Lys 
    1025                 1030                 1035             


Gly Leu  Lys His Val Val Gln  Cys Val Phe Val Ala  Ile Arg Xaa 
    1040                 1045                 1050             


Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu Leu Gln  Phe Met Phe 
    1055                 1060                 1065             


Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly Lys Leu  Tyr Xaa Cys 
    1070                 1075                 1080             


Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu Cys Lys  Gly Asn Tyr 
    1085                 1090                 1095             


Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His Pro Ile  Ile Gln Pro 
    1100                 1105                 1110             


Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe Asp Asn  Val Leu Ala 
    1115                 1120                 1125             


Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa Phe Glu  Gly Trp Pro 
    1130                 1135                 1140             


Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His Xaa Glu  Asp Lys Gly 
    1145                 1150                 1155             


Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser Ile Phe  Phe Ile Ile 
    1160                 1165                 1170             


Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met Asn Ile  Phe Val Gly 
    1175                 1180                 1185             


Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly Glu Gln  Glu Tyr Lys 
    1190                 1195                 1200             


Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln Cys Val  Glu Tyr Ala 
    1205                 1210                 1215             


Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile Pro Lys  Asn Gln His 
    1220                 1225                 1230             


Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser Xaa Tyr  Phe Glu Tyr 
    1235                 1240                 1245             


Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa Ile Cys  Leu Ala Met 
    1250                 1255                 1260             


Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys Ile Ala  Met Asn Ile 
    1265                 1270                 1275             


Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa Val Glu  Met Ile Leu 
    1280                 1285                 1290             


Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr Phe Cys  Asp Ala Trp 
    1295                 1300                 1305             


Asn Xaa  Phe Asp Ala Leu Ile  Val Val Gly Ser Ile  Val Asp Ile 
    1310                 1315                 1320             


Ala Ile  Xaa Glu Val Asn Pro  Ala Glu His Xaa Gln  Cys Ser Pro 
    1325                 1330                 1335             


Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile Ser Ile  Xaa Phe Phe 
    1340                 1345                 1350             


Arg Leu  Phe Arg Val Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly 
    1355                 1360                 1365             


Glu Gly  Ile Arg Xaa Leu Leu  Trp Xaa Phe Ile Lys  Ser Phe Gln 
    1370                 1375                 1380             


Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val Met Leu  Phe Phe Ile 
    1385                 1390                 1395             


Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly Lys Ile  Ala Leu Asn 
    1400                 1405                 1410             


Asp Xaa  Xaa Glu Ile Asn Arg  Asn Asn Asn Phe Gln  Xaa Phe Pro 
    1415                 1420                 1425             


Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala Xaa Gly  Glu Ala Trp 
    1430                 1435                 1440             


Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly Lys Lys  Cys Ala Pro 
    1445                 1450                 1455             


Glu Ser  Glu Pro Ser Asn Ser  Xaa Glu Gly Glu Xaa  Pro Cys Gly 
    1460                 1465                 1470             


Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser Phe Tyr  Met Leu Cys 
    1475                 1480                 1485             


Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala Val Ile  Met Asp Asn 
    1490                 1495                 1500             


Phe Asp  Tyr Leu Xaa Arg Asp  Trp Ser Ile Leu Gly  Pro His His 
    1505                 1510                 1515             


Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu Tyr Asp  Pro Glu Ala 
    1520                 1525                 1530             


Lys Gly  Arg Ile Lys His Leu  Asp Val Val Xaa Leu  Leu Arg Arg 
    1535                 1540                 1545             


Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu Cys Pro  His Arg Val 
    1550                 1555                 1560             


Ala Cys  Lys Arg Leu Val Ser  Met Asn Met Pro Leu  Asn Ser Asp 
    1565                 1570                 1575             


Gly Xaa  Val Met Phe Asn Ala  Xaa Leu Phe Ala Leu  Val Arg Xaa 
    1580                 1585                 1590             


Ala Leu  Arg Ile Lys Xaa Glu  Gly Asn Leu Glu Gln  Ala Asn Glu 
    1595                 1600                 1605             


Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp Lys Arg  Xaa Ser Met 
    1610                 1615                 1620             


Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala Gly Asp  Asp Glu Val 
    1625                 1630                 1635             


Xaa Val  Gly Lys Phe Tyr Ala  Xaa Phe Leu Ile Gln  Glu Tyr Phe 
    1640                 1645                 1650             


Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly Leu Val  Gly Lys Pro 
    1655                 1660                 1665             


Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala Gly Leu  Arg Xaa Leu 
    1670                 1675                 1680             


His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala Ile Ser  Gly Asp Leu 
    1685                 1690                 1695             


Xaa Ala  Glu Glu Glu Leu Asp  Lys Ala Met Lys Glu  Ala Val Ser 
    1700                 1705                 1710             


Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg Ala Gly  Gly Leu Phe 
    1715                 1720                 1725             


Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp Gly Arg  Ser Ala Phe 
    1730                 1735                 1740             


Pro Gln  Xaa Phe Xaa Xaa Gln  Arg Pro Leu His Ile  Asn Lys Ala 
    1745                 1750                 1755             


Gly Ser  Ser Gln Gly Asp Xaa  Glu Ser Pro Ser His  Glu Lys Leu 
    1760                 1765                 1770             


Val Asp  Ser Xaa Phe Xaa Pro  Ser Ser Tyr Ser Ser  Xaa Gly Ser 
    1775                 1780                 1785             


Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Xaa Ala Leu  Gly Arg Leu 
    1790                 1795                 1800             


Pro Arg  Pro Ala Gly Tyr Pro  Ser Xaa Val Ser Xaa  Val Glu Gly 
    1805                 1810                 1815             


His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg Val Gln  Glu Val Ala 
    1820                 1825                 1830             


Trp Lys  Leu Ser Ser Asn Arg  Cys His Ser Arg Glu  Ser Gln Ala 
    1835                 1840                 1845             


Ala Met  Ala Gly Gln Glu Glu  Xaa Ser Gln Asp Glu  Xaa Tyr Glu 
    1850                 1855                 1860             


Val Lys  Met Asn His Asp Xaa  Glu Ala Cys Ser Glu  Pro Ser Leu 
    1865                 1870                 1875             


Leu Ser  Xaa Glu Met Leu Ser  Tyr Gln Asp Asp Glu  Asn Arg Gln 
    1880                 1885                 1890             


Leu Xaa  Leu Pro Glu Glu Asp  Lys Arg Asp Ile Arg  Gln Ser Pro 
    1895                 1900                 1905             


Lys Arg  Gly Phe Leu Arg Ser  Ala Ser Leu Gly Arg  Arg Ala Ser 
    1910                 1915                 1920             


Phe His  Leu Glu Cys Leu Lys  Arg Gln Lys Asp Arg  Gly Gly Asp 
    1925                 1930                 1935             


Ile Ser  Gln Lys Xaa Val Leu  Pro Leu His Leu Val  His His Gln 
    1940                 1945                 1950             


Ala Leu  Ala Val Ala Gly Leu  Ser Pro Leu Leu Gln  Arg Ser His 
    1955                 1960                 1965             


Ser Pro  Ala Ser Phe Pro Arg  Pro Phe Ala Xaa Pro  Pro Ala Xaa 
    1970                 1975                 1980             


Pro Gly  Ser Arg Gly Trp Pro  Pro Gln Pro Val Pro  Xaa Leu Arg 
    1985                 1990                 1995             


Leu Glu  Gly Val Glu Ser Ser  Glu Lys Leu Asn Ser  Ser Phe Pro 
    2000                 2005                 2010             


Ser Ile  His Cys Gly Ser Trp  Ala Glu Xaa Xaa Pro  Gly Gly Gly 
    2015                 2020                 2025             


Gly Ser  Ser Ala Ala Arg Arg  Val Arg Pro Val Ser  Leu Met Val 
    2030                 2035                 2040             


Pro Ser  Gln Ala Gly Ala Pro  Gly Arg Gln Phe His  Gly Ser Ala 
    2045                 2050                 2055             


Ser Ser  Leu Val Glu Ala Val  Leu Ile Ser Glu Gly  Leu Gly Gln 
    2060                 2065                 2070             


Phe Ala  Gln Asp Pro Lys Phe  Ile Glu Val Xaa Xaa  Gln Glu Leu 
    2075                 2080                 2085             


Ala Asp  Ala Cys Asp Met Xaa  Ile Glu Glu Met Glu  Ser Ala Ala 
    2090                 2095                 2100             


Asp Asn  Ile Leu Ser Gly Gly  Ala Pro Gln Ser Pro  Asn Gly Ala 
    2105                 2110                 2115             


Leu Leu  Pro Phe Val Asn Cys  Arg Asp Ala Gly Gln  Asp Arg Ala 
    2120                 2125                 2130             


Gly Gly  Glu Glu Asp Ala Gly  Cys Val Arg Ala Arg  Gly Arg Pro 
    2135                 2140                 2145             


Ser Glu  Glu Glu Leu Gln Asp  Ser Arg Val Tyr Val  Ser Ser Leu 
    2150                 2155                 2160             


<210> 4668
<211> 2166
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1313)..(1313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1337)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1354)..(1354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1380)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1418)..(1419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1429)..(1429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1442)..(1442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1469)..(1469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1511)..(1511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1583)..(1583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1589)..(1589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1602)..(1602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1624)..(1624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1642)..(1642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1649)..(1649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1685)..(1685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1702)..(1702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1749)..(1749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1751)..(1752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1768)..(1768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1780)..(1780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1782)..(1782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1789)..(1789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1801)..(1801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1815)..(1815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1818)..(1818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1859)..(1859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1864)..(1864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1873)..(1873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1884)..(1884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1898)..(1898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1946)..(1946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1982)..(1982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1986)..(1986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1999)..(1999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2026)..(2027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2087)..(2088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2098)..(2098)
<223> Selenocysteine

<400> 4668
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Xaa Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Xaa Xaa Ile Phe 
    930                 935                 940                 


Xaa Ile Glu Ile Ala Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys Gly Tyr 
    1265                 1270                 1275             


Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe Leu Ile  Val Ile Gly 
    1280                 1285                 1290             


Ser Ile  Ile Asp Val Ile Leu  Ser Glu Xaa Asn His  Tyr Phe Cys 
    1295                 1300                 1305             


Asp Ala  Trp Asn Xaa Phe Asp  Ala Leu Ile Val Val  Gly Ser Ile 
    1310                 1315                 1320             


Val Asp  Ile Ala Ile Xaa Glu  Val Asn Pro Ala Glu  His Xaa Gln 
    1325                 1330                 1335             


Cys Ser  Pro Ser Met Asn Ala  Glu Glu Asn Ser Arg  Ile Ser Ile 
    1340                 1345                 1350             


Xaa Phe  Phe Arg Leu Phe Arg  Val Met Arg Leu Val  Lys Leu Leu 
    1355                 1360                 1365             


Ser Arg  Gly Glu Gly Ile Arg  Xaa Leu Leu Trp Xaa  Phe Ile Lys 
    1370                 1375                 1380             


Ser Phe  Gln Ala Leu Pro Tyr  Val Ala Leu Leu Ile  Val Met Leu 
    1385                 1390                 1395             


Phe Phe  Ile Tyr Ala Val Ile  Gly Met Gln Val Phe  Gly Lys Ile 
    1400                 1405                 1410             


Ala Leu  Asn Asp Xaa Xaa Glu  Ile Asn Arg Asn Asn  Asn Phe Gln 
    1415                 1420                 1425             


Xaa Phe  Pro Gln Ala Val Leu  Leu Leu Phe Arg Cys  Ala Xaa Gly 
    1430                 1435                 1440             


Glu Ala  Trp Gln Asp Ile Met  Leu Ala Cys Met Pro  Gly Lys Lys 
    1445                 1450                 1455             


Cys Ala  Pro Glu Ser Glu Pro  Ser Asn Ser Xaa Glu  Gly Glu Xaa 
    1460                 1465                 1470             


Pro Cys  Gly Ser Ser Phe Ala  Val Phe Tyr Phe Ile  Ser Phe Tyr 
    1475                 1480                 1485             


Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu Phe Val  Ala Val Ile 
    1490                 1495                 1500             


Met Asp  Asn Phe Asp Tyr Leu  Xaa Arg Asp Trp Ser  Ile Leu Gly 
    1505                 1510                 1515             


Pro His  His Leu Asp Glu Phe  Lys Arg Ile Trp Ala  Glu Tyr Asp 
    1520                 1525                 1530             


Pro Glu  Ala Lys Gly Arg Ile  Lys His Leu Asp Val  Val Xaa Leu 
    1535                 1540                 1545             


Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe Gly Lys  Leu Cys Pro 
    1550                 1555                 1560             


His Arg  Val Ala Cys Lys Arg  Leu Val Ser Met Asn  Met Pro Leu 
    1565                 1570                 1575             


Asn Ser  Asp Gly Xaa Val Met  Phe Asn Ala Xaa Leu  Phe Ala Leu 
    1580                 1585                 1590             


Val Arg  Xaa Ala Leu Arg Ile  Lys Xaa Glu Gly Asn  Leu Glu Gln 
    1595                 1600                 1605             


Ala Asn  Glu Glu Leu Arg Ala  Ile Ile Lys Lys Ile  Trp Lys Arg 
    1610                 1615                 1620             


Xaa Ser  Met Lys Leu Leu Asp  Gln Val Val Pro Pro  Ala Gly Asp 
    1625                 1630                 1635             


Asp Glu  Val Xaa Val Gly Lys  Phe Tyr Ala Xaa Phe  Leu Ile Gln 
    1640                 1645                 1650             


Glu Tyr  Phe Arg Lys Phe Lys  Lys Arg Lys Glu Gln  Gly Leu Val 
    1655                 1660                 1665             


Gly Lys  Pro Ser Gln Arg Asn  Ala Leu Ser Leu Gln  Ala Gly Leu 
    1670                 1675                 1680             


Arg Xaa  Leu His Asp Ile Gly  Pro Glu Ile Arg Arg  Ala Ile Ser 
    1685                 1690                 1695             


Gly Asp  Leu Xaa Ala Glu Glu  Glu Leu Asp Lys Ala  Met Lys Glu 
    1700                 1705                 1710             


Ala Val  Ser Ala Ala Ser Glu  Asp Asp Ile Phe Arg  Arg Ala Gly 
    1715                 1720                 1725             


Gly Leu  Phe Gly Asn His Val  Ser Tyr Tyr Gln Ser  Asp Gly Arg 
    1730                 1735                 1740             


Ser Ala  Phe Pro Gln Xaa Phe  Xaa Xaa Gln Arg Pro  Leu His Ile 
    1745                 1750                 1755             


Asn Lys  Ala Gly Ser Ser Gln  Gly Asp Xaa Glu Ser  Pro Ser His 
    1760                 1765                 1770             


Glu Lys  Leu Val Asp Ser Xaa  Phe Xaa Pro Ser Ser  Tyr Ser Ser 
    1775                 1780                 1785             


Xaa Gly  Ser Asn Ala Asn Ile  Asn Asn Ala Asn Asn  Xaa Ala Leu 
    1790                 1795                 1800             


Gly Arg  Leu Pro Arg Pro Ala  Gly Tyr Pro Ser Xaa  Val Ser Xaa 
    1805                 1810                 1815             


Val Glu  Gly His Gly Pro Pro  Leu Ser Pro Ala Ile  Arg Val Gln 
    1820                 1825                 1830             


Glu Val  Ala Trp Lys Leu Ser  Ser Asn Arg Cys His  Ser Arg Glu 
    1835                 1840                 1845             


Ser Gln  Ala Ala Met Ala Gly  Gln Glu Glu Xaa Ser  Gln Asp Glu 
    1850                 1855                 1860             


Xaa Tyr  Glu Val Lys Met Asn  His Asp Xaa Glu Ala  Cys Ser Glu 
    1865                 1870                 1875             


Pro Ser  Leu Leu Ser Xaa Glu  Met Leu Ser Tyr Gln  Asp Asp Glu 
    1880                 1885                 1890             


Asn Arg  Gln Leu Xaa Leu Pro  Glu Glu Asp Lys Arg  Asp Ile Arg 
    1895                 1900                 1905             


Gln Ser  Pro Lys Arg Gly Phe  Leu Arg Ser Ala Ser  Leu Gly Arg 
    1910                 1915                 1920             


Arg Ala  Ser Phe His Leu Glu  Cys Leu Lys Arg Gln  Lys Asp Arg 
    1925                 1930                 1935             


Gly Gly  Asp Ile Ser Gln Lys  Xaa Val Leu Pro Leu  His Leu Val 
    1940                 1945                 1950             


His His  Gln Ala Leu Ala Val  Ala Gly Leu Ser Pro  Leu Leu Gln 
    1955                 1960                 1965             


Arg Ser  His Ser Pro Ala Ser  Phe Pro Arg Pro Phe  Ala Xaa Pro 
    1970                 1975                 1980             


Pro Ala  Xaa Pro Gly Ser Arg  Gly Trp Pro Pro Gln  Pro Val Pro 
    1985                 1990                 1995             


Xaa Leu  Arg Leu Glu Gly Val  Glu Ser Ser Glu Lys  Leu Asn Ser 
    2000                 2005                 2010             


Ser Phe  Pro Ser Ile His Cys  Gly Ser Trp Ala Glu  Xaa Xaa Pro 
    2015                 2020                 2025             


Gly Gly  Gly Gly Ser Ser Ala  Ala Arg Arg Val Arg  Pro Val Ser 
    2030                 2035                 2040             


Leu Met  Val Pro Ser Gln Ala  Gly Ala Pro Gly Arg  Gln Phe His 
    2045                 2050                 2055             


Gly Ser  Ala Ser Ser Leu Val  Glu Ala Val Leu Ile  Ser Glu Gly 
    2060                 2065                 2070             


Leu Gly  Gln Phe Ala Gln Asp  Pro Lys Phe Ile Glu  Val Xaa Xaa 
    2075                 2080                 2085             


Gln Glu  Leu Ala Asp Ala Cys  Asp Met Xaa Ile Glu  Glu Met Glu 
    2090                 2095                 2100             


Ser Ala  Ala Asp Asn Ile Leu  Ser Gly Gly Ala Pro  Gln Ser Pro 
    2105                 2110                 2115             


Asn Gly  Ala Leu Leu Pro Phe  Val Asn Cys Arg Asp  Ala Gly Gln 
    2120                 2125                 2130             


Asp Arg  Ala Gly Gly Glu Glu  Asp Ala Gly Cys Val  Arg Ala Arg 
    2135                 2140                 2145             


Gly Arg  Pro Ser Glu Glu Glu  Leu Gln Asp Ser Arg  Val Tyr Val 
    2150                 2155                 2160             


Ser Ser  Leu 
    2165     


<210> 4669
<211> 2173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1561)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1614)..(1614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1674)..(1674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1723)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1752)..(1752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1836)..(1836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1866)..(1866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1871)..(1871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1880)..(1880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1891)..(1891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1905)..(1905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1953)..(1953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1989)..(1989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1993)..(1993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2006)..(2006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2033)..(2034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2094)..(2095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2105)..(2105)
<223> Selenocysteine

<400> 4669
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Xaa Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Gly Asn Ala Asp Tyr Val Phe Xaa Ser Ile Phe 
    930                 935                 940                 


Xaa Leu Glu Ile Ile Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Xaa  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Xaa Glu Val Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Xaa Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Xaa Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Xaa Leu Leu  Trp Xaa Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Xaa  Xaa Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Xaa Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Xaa Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Xaa Glu Gly 
    1430                 1435                 1440             


Glu Xaa  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Xaa Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Xaa Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Xaa  Val Met Phe Asn Ala  Xaa Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Xaa Ala Leu  Arg Ile Lys Xaa Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Xaa Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Xaa Val  Gly Lys Phe Tyr Ala  Xaa Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Xaa Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Xaa Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Gly Arg  Ser Ala Phe Pro Gln  Xaa Phe Xaa Xaa Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly Asp Xaa  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Xaa Phe Xaa Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Xaa Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Xaa 
    1760                 1765                 1770             


Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly Tyr Pro  Ser Xaa Val 
    1775                 1780                 1785             


Ser Xaa  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg 
    1790                 1795                 1800             


Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser Asn Arg  Glu Arg His 
    1805                 1810                 1815             


Val Pro  Met Cys Glu Asp Leu  Glu Leu Arg Arg Asp  Ser Gly Ser 
    1820                 1825                 1830             


Ala Gly  Xaa Gln Ala His Cys  Leu Leu Leu Arg Arg  Ala Asn Pro 
    1835                 1840                 1845             


Ser Arg  Cys His Ser Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln 
    1850                 1855                 1860             


Glu Glu  Xaa Ser Gln Asp Glu  Xaa Tyr Glu Val Lys  Met Asn His 
    1865                 1870                 1875             


Asp Xaa  Glu Ala Cys Ser Glu  Pro Ser Leu Leu Ser  Xaa Glu Met 
    1880                 1885                 1890             


Leu Ser  Tyr Gln Asp Asp Glu  Asn Arg Gln Leu Xaa  Leu Pro Glu 
    1895                 1900                 1905             


Glu Asp  Lys Arg Asp Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu 
    1910                 1915                 1920             


Arg Ser  Ala Ser Leu Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys 
    1925                 1930                 1935             


Leu Lys  Arg Gln Lys Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Xaa 
    1940                 1945                 1950             


Val Leu  Pro Leu His Leu Val  His His Gln Ala Leu  Ala Val Ala 
    1955                 1960                 1965             


Gly Leu  Ser Pro Leu Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe 
    1970                 1975                 1980             


Pro Arg  Pro Phe Ala Xaa Pro  Pro Ala Xaa Pro Gly  Ser Arg Gly 
    1985                 1990                 1995             


Trp Pro  Pro Gln Pro Val Pro  Xaa Leu Arg Leu Glu  Gly Val Glu 
    2000                 2005                 2010             


Ser Ser  Glu Lys Leu Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly 
    2015                 2020                 2025             


Ser Trp  Ala Glu Xaa Xaa Pro  Gly Gly Gly Gly Ser  Ser Ala Ala 
    2030                 2035                 2040             


Arg Arg  Val Arg Pro Val Ser  Leu Met Val Pro Ser  Gln Ala Gly 
    2045                 2050                 2055             


Ala Pro  Gly Arg Gln Phe His  Gly Ser Ala Ser Ser  Leu Val Glu 
    2060                 2065                 2070             


Ala Val  Leu Ile Ser Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro 
    2075                 2080                 2085             


Lys Phe  Ile Glu Val Xaa Xaa  Gln Glu Leu Ala Asp  Ala Cys Asp 
    2090                 2095                 2100             


Met Xaa  Ile Glu Glu Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser 
    2105                 2110                 2115             


Gly Gly  Ala Pro Gln Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val 
    2120                 2125                 2130             


Asn Cys  Arg Asp Ala Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp 
    2135                 2140                 2145             


Ala Gly  Cys Val Arg Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu 
    2150                 2155                 2160             


Gln Asp  Ser Arg Val Tyr Val  Ser Ser Leu 
    2165                 2170             


<210> 4670
<211> 2173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1561)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1614)..(1614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1674)..(1674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1723)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1752)..(1752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1836)..(1836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1866)..(1866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1871)..(1871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1880)..(1880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1891)..(1891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1905)..(1905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1953)..(1953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1989)..(1989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1993)..(1993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2006)..(2006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2033)..(2034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2094)..(2095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2105)..(2105)
<223> Selenocysteine

<400> 4670
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr 
    370                 375                 380                 


Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Xaa Xaa Ile Phe 
    930                 935                 940                 


Xaa Ile Glu Ile Ala Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys Gly Tyr 
    1265                 1270                 1275             


Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe Leu Ile  Val Ile Gly 
    1280                 1285                 1290             


Ser Ile  Ile Asp Val Ile Leu  Ser Glu Xaa Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Xaa Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Xaa Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Xaa Leu Leu  Trp Xaa Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Xaa  Xaa Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Xaa Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Xaa Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Xaa Glu Gly 
    1430                 1435                 1440             


Glu Xaa  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Xaa Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Xaa Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Xaa  Val Met Phe Asn Ala  Xaa Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Xaa Ala Leu  Arg Ile Lys Xaa Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Xaa Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Xaa Val  Gly Lys Phe Tyr Ala  Xaa Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Xaa Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Xaa Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Gly Arg  Ser Ala Phe Pro Gln  Xaa Phe Xaa Xaa Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly Asp Xaa  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Xaa Phe Xaa Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Xaa Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Xaa 
    1760                 1765                 1770             


Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly Tyr Pro  Ser Xaa Val 
    1775                 1780                 1785             


Ser Xaa  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg 
    1790                 1795                 1800             


Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser Asn Arg  Glu Arg His 
    1805                 1810                 1815             


Val Pro  Met Cys Glu Asp Leu  Glu Leu Arg Arg Asp  Ser Gly Ser 
    1820                 1825                 1830             


Ala Gly  Xaa Gln Ala His Cys  Leu Leu Leu Arg Arg  Ala Asn Pro 
    1835                 1840                 1845             


Ser Arg  Cys His Ser Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln 
    1850                 1855                 1860             


Glu Glu  Xaa Ser Gln Asp Glu  Xaa Tyr Glu Val Lys  Met Asn His 
    1865                 1870                 1875             


Asp Xaa  Glu Ala Cys Ser Glu  Pro Ser Leu Leu Ser  Xaa Glu Met 
    1880                 1885                 1890             


Leu Ser  Tyr Gln Asp Asp Glu  Asn Arg Gln Leu Xaa  Leu Pro Glu 
    1895                 1900                 1905             


Glu Asp  Lys Arg Asp Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu 
    1910                 1915                 1920             


Arg Ser  Ala Ser Leu Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys 
    1925                 1930                 1935             


Leu Lys  Arg Gln Lys Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Xaa 
    1940                 1945                 1950             


Val Leu  Pro Leu His Leu Val  His His Gln Ala Leu  Ala Val Ala 
    1955                 1960                 1965             


Gly Leu  Ser Pro Leu Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe 
    1970                 1975                 1980             


Pro Arg  Pro Phe Ala Xaa Pro  Pro Ala Xaa Pro Gly  Ser Arg Gly 
    1985                 1990                 1995             


Trp Pro  Pro Gln Pro Val Pro  Xaa Leu Arg Leu Glu  Gly Val Glu 
    2000                 2005                 2010             


Ser Ser  Glu Lys Leu Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly 
    2015                 2020                 2025             


Ser Trp  Ala Glu Xaa Xaa Pro  Gly Gly Gly Gly Ser  Ser Ala Ala 
    2030                 2035                 2040             


Arg Arg  Val Arg Pro Val Ser  Leu Met Val Pro Ser  Gln Ala Gly 
    2045                 2050                 2055             


Ala Pro  Gly Arg Gln Phe His  Gly Ser Ala Ser Ser  Leu Val Glu 
    2060                 2065                 2070             


Ala Val  Leu Ile Ser Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro 
    2075                 2080                 2085             


Lys Phe  Ile Glu Val Xaa Xaa  Gln Glu Leu Ala Asp  Ala Cys Asp 
    2090                 2095                 2100             


Met Xaa  Ile Glu Glu Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser 
    2105                 2110                 2115             


Gly Gly  Ala Pro Gln Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val 
    2120                 2125                 2130             


Asn Cys  Arg Asp Ala Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp 
    2135                 2140                 2145             


Ala Gly  Cys Val Arg Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu 
    2150                 2155                 2160             


Gln Asp  Ser Arg Val Tyr Val  Ser Ser Leu 
    2165                 2170             


<210> 4671
<211> 2179
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1328)..(1328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1374)..(1374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1412)..(1413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1436)..(1436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1463)..(1463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1467)..(1467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1505)..(1505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1541)..(1541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1577)..(1577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1583)..(1583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1590)..(1590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1637)..(1637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1655)..(1655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1662)..(1662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1698)..(1698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1715)..(1715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1762)..(1762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1764)..(1765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1781)..(1781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1793)..(1793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1795)..(1795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1802)..(1802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1814)..(1814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1828)..(1828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1831)..(1831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1872)..(1872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1877)..(1877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1886)..(1886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1897)..(1897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1911)..(1911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1959)..(1959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1995)..(1995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1999)..(1999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2012)..(2012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2039)..(2040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2100)..(2101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2111)..(2111)
<223> Selenocysteine

<400> 4671
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Xaa Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Xaa Xaa Ile Phe 
    930                 935                 940                 


Xaa Ile Glu Ile Ala Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Xaa  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Xaa Glu Val Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Xaa Gln  Cys Ser Pro Ser Met  Gly Pro Ser Cys Ser  His Pro Pro 
    1310                 1315                 1320             


Leu Ala  Val Leu Xaa Ala Pro  Pro Val Ala Asp Gly  Phe Gln Asn 
    1325                 1330                 1335             


Ala Glu  Glu Asn Ser Arg Ile  Ser Ile Xaa Phe Phe  Arg Leu Phe 
    1340                 1345                 1350             


Arg Val  Met Arg Leu Val Lys  Leu Leu Ser Arg Gly  Glu Gly Ile 
    1355                 1360                 1365             


Arg Xaa  Leu Leu Trp Xaa Phe  Ile Lys Ser Phe Gln  Ala Leu Pro 
    1370                 1375                 1380             


Tyr Val  Ala Leu Leu Ile Val  Met Leu Phe Phe Ile  Tyr Ala Val 
    1385                 1390                 1395             


Ile Gly  Met Gln Val Phe Gly  Lys Ile Ala Leu Asn  Asp Xaa Xaa 
    1400                 1405                 1410             


Glu Ile  Asn Arg Asn Asn Asn  Phe Gln Xaa Phe Pro  Gln Ala Val 
    1415                 1420                 1425             


Leu Leu  Leu Phe Arg Cys Ala  Xaa Gly Glu Ala Trp  Gln Asp Ile 
    1430                 1435                 1440             


Met Leu  Ala Cys Met Pro Gly  Lys Lys Cys Ala Pro  Glu Ser Glu 
    1445                 1450                 1455             


Pro Ser  Asn Ser Xaa Glu Gly  Glu Xaa Pro Cys Gly  Ser Ser Phe 
    1460                 1465                 1470             


Ala Val  Phe Tyr Phe Ile Ser  Phe Tyr Met Leu Cys  Ala Phe Leu 
    1475                 1480                 1485             


Ile Ile  Asn Leu Phe Val Ala  Val Ile Met Asp Asn  Phe Asp Tyr 
    1490                 1495                 1500             


Leu Xaa  Arg Asp Trp Ser Ile  Leu Gly Pro His His  Leu Asp Glu 
    1505                 1510                 1515             


Phe Lys  Arg Ile Trp Ala Glu  Tyr Asp Pro Glu Ala  Lys Gly Arg 
    1520                 1525                 1530             


Ile Lys  His Leu Asp Val Val  Xaa Leu Leu Arg Arg  Ile Gln Pro 
    1535                 1540                 1545             


Pro Leu  Gly Phe Gly Lys Leu  Cys Pro His Arg Val  Ala Cys Lys 
    1550                 1555                 1560             


Arg Leu  Val Ser Met Asn Met  Pro Leu Asn Ser Asp  Gly Xaa Val 
    1565                 1570                 1575             


Met Phe  Asn Ala Xaa Leu Phe  Ala Leu Val Arg Xaa  Ala Leu Arg 
    1580                 1585                 1590             


Ile Lys  Xaa Glu Glu Gly Pro  Ser Pro Ser Glu Ala  His Gln Gly 
    1595                 1600                 1605             


Ala Glu  Asp Pro Phe Arg Pro  Ala Gly Asn Leu Glu  Gln Ala Asn 
    1610                 1615                 1620             


Glu Glu  Leu Arg Ala Ile Ile  Lys Lys Ile Trp Lys  Arg Xaa Ser 
    1625                 1630                 1635             


Met Lys  Leu Leu Asp Gln Val  Val Pro Pro Ala Gly  Asp Asp Glu 
    1640                 1645                 1650             


Val Xaa  Val Gly Lys Phe Tyr  Ala Xaa Phe Leu Ile  Gln Glu Tyr 
    1655                 1660                 1665             


Phe Arg  Lys Phe Lys Lys Arg  Lys Glu Gln Gly Leu  Val Gly Lys 
    1670                 1675                 1680             


Pro Ser  Gln Arg Asn Ala Leu  Ser Leu Gln Ala Gly  Leu Arg Xaa 
    1685                 1690                 1695             


Leu His  Asp Ile Gly Pro Glu  Ile Arg Arg Ala Ile  Ser Gly Asp 
    1700                 1705                 1710             


Leu Xaa  Ala Glu Glu Glu Leu  Asp Lys Ala Met Lys  Glu Ala Val 
    1715                 1720                 1725             


Ser Ala  Ala Ser Glu Asp Asp  Ile Phe Arg Arg Ala  Gly Gly Leu 
    1730                 1735                 1740             


Phe Gly  Asn His Val Ser Tyr  Tyr Gln Ser Asp Gly  Arg Ser Ala 
    1745                 1750                 1755             


Phe Pro  Gln Xaa Phe Xaa Xaa  Gln Arg Pro Leu His  Ile Asn Lys 
    1760                 1765                 1770             


Ala Gly  Ser Ser Gln Gly Asp  Xaa Glu Ser Pro Ser  His Glu Lys 
    1775                 1780                 1785             


Leu Val  Asp Ser Xaa Phe Xaa  Pro Ser Ser Tyr Ser  Ser Xaa Gly 
    1790                 1795                 1800             


Ser Asn  Ala Asn Ile Asn Asn  Ala Asn Asn Xaa Ala  Leu Gly Arg 
    1805                 1810                 1815             


Leu Pro  Arg Pro Ala Gly Tyr  Pro Ser Xaa Val Ser  Xaa Val Glu 
    1820                 1825                 1830             


Gly His  Gly Pro Pro Leu Ser  Pro Ala Ile Arg Val  Gln Glu Val 
    1835                 1840                 1845             


Ala Trp  Lys Leu Ser Ser Asn  Arg Cys His Ser Arg  Glu Ser Gln 
    1850                 1855                 1860             


Ala Ala  Met Ala Gly Gln Glu  Glu Xaa Ser Gln Asp  Glu Xaa Tyr 
    1865                 1870                 1875             


Glu Val  Lys Met Asn His Asp  Xaa Glu Ala Cys Ser  Glu Pro Ser 
    1880                 1885                 1890             


Leu Leu  Ser Xaa Glu Met Leu  Ser Tyr Gln Asp Asp  Glu Asn Arg 
    1895                 1900                 1905             


Gln Leu  Xaa Leu Pro Glu Glu  Asp Lys Arg Asp Ile  Arg Gln Ser 
    1910                 1915                 1920             


Pro Lys  Arg Gly Phe Leu Arg  Ser Ala Ser Leu Gly  Arg Arg Ala 
    1925                 1930                 1935             


Ser Phe  His Leu Glu Cys Leu  Lys Arg Gln Lys Asp  Arg Gly Gly 
    1940                 1945                 1950             


Asp Ile  Ser Gln Lys Xaa Val  Leu Pro Leu His Leu  Val His His 
    1955                 1960                 1965             


Gln Ala  Leu Ala Val Ala Gly  Leu Ser Pro Leu Leu  Gln Arg Ser 
    1970                 1975                 1980             


His Ser  Pro Ala Ser Phe Pro  Arg Pro Phe Ala Xaa  Pro Pro Ala 
    1985                 1990                 1995             


Xaa Pro  Gly Ser Arg Gly Trp  Pro Pro Gln Pro Val  Pro Xaa Leu 
    2000                 2005                 2010             


Arg Leu  Glu Gly Val Glu Ser  Ser Glu Lys Leu Asn  Ser Ser Phe 
    2015                 2020                 2025             


Pro Ser  Ile His Cys Gly Ser  Trp Ala Glu Xaa Xaa  Pro Gly Gly 
    2030                 2035                 2040             


Gly Gly  Ser Ser Ala Ala Arg  Arg Val Arg Pro Val  Ser Leu Met 
    2045                 2050                 2055             


Val Pro  Ser Gln Ala Gly Ala  Pro Gly Arg Gln Phe  His Gly Ser 
    2060                 2065                 2070             


Ala Ser  Ser Leu Val Glu Ala  Val Leu Ile Ser Glu  Gly Leu Gly 
    2075                 2080                 2085             


Gln Phe  Ala Gln Asp Pro Lys  Phe Ile Glu Val Xaa  Xaa Gln Glu 
    2090                 2095                 2100             


Leu Ala  Asp Ala Cys Asp Met  Xaa Ile Glu Glu Met  Glu Ser Ala 
    2105                 2110                 2115             


Ala Asp  Asn Ile Leu Ser Gly  Gly Ala Pro Gln Ser  Pro Asn Gly 
    2120                 2125                 2130             


Ala Leu  Leu Pro Phe Val Asn  Cys Arg Asp Ala Gly  Gln Asp Arg 
    2135                 2140                 2145             


Ala Gly  Gly Glu Glu Asp Ala  Gly Cys Val Arg Ala  Arg Gly Arg 
    2150                 2155                 2160             


Pro Ser  Glu Glu Glu Leu Gln  Asp Ser Arg Val Tyr  Val Ser Ser 
    2165                 2170                 2175             


Leu 
    


<210> 4672
<211> 2186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1253)..(1253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1323)..(1323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1349)..(1349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1357)..(1357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1374)..(1374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1396)..(1396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1400)..(1400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1438)..(1439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1449)..(1449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1462)..(1462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1489)..(1489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1493)..(1493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1531)..(1531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1567)..(1567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1603)..(1603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1616)..(1616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1622)..(1622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1644)..(1644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1662)..(1662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1669)..(1669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1705)..(1705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1722)..(1722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1769)..(1769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1771)..(1772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1788)..(1788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1800)..(1800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1802)..(1802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1809)..(1809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1821)..(1821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1835)..(1835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1838)..(1838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1879)..(1879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1884)..(1884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1893)..(1893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1904)..(1904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1918)..(1918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1966)..(1966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2002)..(2002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2006)..(2006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2019)..(2019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2046)..(2047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2107)..(2108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2118)..(2118)
<223> Selenocysteine

<400> 4672
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Xaa Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Xaa Xaa Ile Phe 
    930                 935                 940                 


Xaa Ile Glu Ile Ala Leu Lys Ile Leu Gly Asn Ala Asp Tyr Val Phe 
945                 950                 955                 960 


Xaa Ser Ile Phe Xaa Leu Glu Ile Ile Leu Lys Met Xaa Ala Tyr Gly 
                965                 970                 975     


Ala Phe Leu His Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu 
            980                 985                 990         


Asp Leu Leu Val Val Ser Val Ser  Leu Ile Ser Phe Gly  Ile Gln Ser 
        995                 1000                 1005             


Ser Ala  Ile Asn Val Val Lys  Ile Leu Arg Val Leu  Arg Val Leu 
    1010                 1015                 1020             


Arg Pro  Leu Arg Ala Ile Asn  Arg Ala Lys Gly Leu  Lys His Val 
    1025                 1030                 1035             


Val Gln  Cys Val Phe Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val 
    1040                 1045                 1050             


Ile Val  Xaa Xaa Leu Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val 
    1055                 1060                 1065             


Gln Leu  Phe Lys Gly Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys 
    1070                 1075                 1080             


Gln Xaa  Glu Ala Glu Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp 
    1085                 1090                 1095             


Gly Glu  Val Asp His Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn 
    1100                 1105                 1110             


Ser Lys  Phe Asp Phe Asp Asn  Val Leu Ala Ala Met  Met Ala Leu 
    1115                 1120                 1125             


Phe Xaa  Val Ser Xaa Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg 
    1130                 1135                 1140             


Ser Ile  Asp Ser His Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr 
    1145                 1150                 1155             


Arg Val  Glu Ile Ser Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile 
    1160                 1165                 1170             


Ala Phe  Phe Met Met Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa 
    1175                 1180                 1185             


Phe Gln  Glu Gln Gly Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp 
    1190                 1195                 1200             


Lys Asn  Gln Arg Gln Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro 
    1205                 1210                 1215             


Leu Arg  Arg Tyr Ile Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp 
    1220                 1225                 1230             


Tyr Val  Val Asn Ser Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu 
    1235                 1240                 1245             


Ile Leu  Leu Asn Xaa Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln 
    1250                 1255                 1260             


Ser Cys  Leu Phe Lys Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe 
    1265                 1270                 1275             


Xaa Gly  Leu Phe Xaa Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe 
    1280                 1285                 1290             


Lys Pro  Lys Gly Tyr Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe 
    1295                 1300                 1305             


Leu Ile  Val Ile Gly Ser Ile  Ile Asp Val Ile Leu  Ser Glu Xaa 
    1310                 1315                 1320             


Asn His  Tyr Phe Cys Asp Ala  Trp Asn Xaa Phe Asp  Ala Leu Ile 
    1325                 1330                 1335             


Val Val  Gly Ser Ile Val Asp  Ile Ala Ile Xaa Glu  Val Asn Pro 
    1340                 1345                 1350             


Ala Glu  His Xaa Gln Cys Ser  Pro Ser Met Asn Ala  Glu Glu Asn 
    1355                 1360                 1365             


Ser Arg  Ile Ser Ile Xaa Phe  Phe Arg Leu Phe Arg  Val Met Arg 
    1370                 1375                 1380             


Leu Val  Lys Leu Leu Ser Arg  Gly Glu Gly Ile Arg  Xaa Leu Leu 
    1385                 1390                 1395             


Trp Xaa  Phe Ile Lys Ser Phe  Gln Ala Leu Pro Tyr  Val Ala Leu 
    1400                 1405                 1410             


Leu Ile  Val Met Leu Phe Phe  Ile Tyr Ala Val Ile  Gly Met Gln 
    1415                 1420                 1425             


Val Phe  Gly Lys Ile Ala Leu  Asn Asp Xaa Xaa Glu  Ile Asn Arg 
    1430                 1435                 1440             


Asn Asn  Asn Phe Gln Xaa Phe  Pro Gln Ala Val Leu  Leu Leu Phe 
    1445                 1450                 1455             


Arg Cys  Ala Xaa Gly Glu Ala  Trp Gln Asp Ile Met  Leu Ala Cys 
    1460                 1465                 1470             


Met Pro  Gly Lys Lys Cys Ala  Pro Glu Ser Glu Pro  Ser Asn Ser 
    1475                 1480                 1485             


Xaa Glu  Gly Glu Xaa Pro Cys  Gly Ser Ser Phe Ala  Val Phe Tyr 
    1490                 1495                 1500             


Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu 
    1505                 1510                 1515             


Phe Val  Ala Val Ile Met Asp  Asn Phe Asp Tyr Leu  Xaa Arg Asp 
    1520                 1525                 1530             


Trp Ser  Ile Leu Gly Pro His  His Leu Asp Glu Phe  Lys Arg Ile 
    1535                 1540                 1545             


Trp Ala  Glu Tyr Asp Pro Glu  Ala Lys Gly Arg Ile  Lys His Leu 
    1550                 1555                 1560             


Asp Val  Val Xaa Leu Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe 
    1565                 1570                 1575             


Gly Lys  Leu Cys Pro His Arg  Val Ala Cys Lys Arg  Leu Val Ser 
    1580                 1585                 1590             


Met Asn  Met Pro Leu Asn Ser  Asp Gly Xaa Val Met  Phe Asn Ala 
    1595                 1600                 1605             


Xaa Leu  Phe Ala Leu Val Arg  Xaa Ala Leu Arg Ile  Lys Xaa Glu 
    1610                 1615                 1620             


Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu Arg Ala  Ile Ile Lys 
    1625                 1630                 1635             


Lys Ile  Trp Lys Arg Xaa Ser  Met Lys Leu Leu Asp  Gln Val Val 
    1640                 1645                 1650             


Pro Pro  Ala Gly Asp Asp Glu  Val Xaa Val Gly Lys  Phe Tyr Ala 
    1655                 1660                 1665             


Xaa Phe  Leu Ile Gln Glu Tyr  Phe Arg Lys Phe Lys  Lys Arg Lys 
    1670                 1675                 1680             


Glu Gln  Gly Leu Val Gly Lys  Pro Ser Gln Arg Asn  Ala Leu Ser 
    1685                 1690                 1695             


Leu Gln  Ala Gly Leu Arg Xaa  Leu His Asp Ile Gly  Pro Glu Ile 
    1700                 1705                 1710             


Arg Arg  Ala Ile Ser Gly Asp  Leu Xaa Ala Glu Glu  Glu Leu Asp 
    1715                 1720                 1725             


Lys Ala  Met Lys Glu Ala Val  Ser Ala Ala Ser Glu  Asp Asp Ile 
    1730                 1735                 1740             


Phe Arg  Arg Ala Gly Gly Leu  Phe Gly Asn His Val  Ser Tyr Tyr 
    1745                 1750                 1755             


Gln Ser  Asp Gly Arg Ser Ala  Phe Pro Gln Xaa Phe  Xaa Xaa Gln 
    1760                 1765                 1770             


Arg Pro  Leu His Ile Asn Lys  Ala Gly Ser Ser Gln  Gly Asp Xaa 
    1775                 1780                 1785             


Glu Ser  Pro Ser His Glu Lys  Leu Val Asp Ser Xaa  Phe Xaa Pro 
    1790                 1795                 1800             


Ser Ser  Tyr Ser Ser Xaa Gly  Ser Asn Ala Asn Ile  Asn Asn Ala 
    1805                 1810                 1815             


Asn Asn  Xaa Ala Leu Gly Arg  Leu Pro Arg Pro Ala  Gly Tyr Pro 
    1820                 1825                 1830             


Ser Xaa  Val Ser Xaa Val Glu  Gly His Gly Pro Pro  Leu Ser Pro 
    1835                 1840                 1845             


Ala Ile  Arg Val Gln Glu Val  Ala Trp Lys Leu Ser  Ser Asn Arg 
    1850                 1855                 1860             


Cys His  Ser Arg Glu Ser Gln  Ala Ala Met Ala Gly  Gln Glu Glu 
    1865                 1870                 1875             


Xaa Ser  Gln Asp Glu Xaa Tyr  Glu Val Lys Met Asn  His Asp Xaa 
    1880                 1885                 1890             


Glu Ala  Cys Ser Glu Pro Ser  Leu Leu Ser Xaa Glu  Met Leu Ser 
    1895                 1900                 1905             


Tyr Gln  Asp Asp Glu Asn Arg  Gln Leu Xaa Leu Pro  Glu Glu Asp 
    1910                 1915                 1920             


Lys Arg  Asp Ile Arg Gln Ser  Pro Lys Arg Gly Phe  Leu Arg Ser 
    1925                 1930                 1935             


Ala Ser  Leu Gly Arg Arg Ala  Ser Phe His Leu Glu  Cys Leu Lys 
    1940                 1945                 1950             


Arg Gln  Lys Asp Arg Gly Gly  Asp Ile Ser Gln Lys  Xaa Val Leu 
    1955                 1960                 1965             


Pro Leu  His Leu Val His His  Gln Ala Leu Ala Val  Ala Gly Leu 
    1970                 1975                 1980             


Ser Pro  Leu Leu Gln Arg Ser  His Ser Pro Ala Ser  Phe Pro Arg 
    1985                 1990                 1995             


Pro Phe  Ala Xaa Pro Pro Ala  Xaa Pro Gly Ser Arg  Gly Trp Pro 
    2000                 2005                 2010             


Pro Gln  Pro Val Pro Xaa Leu  Arg Leu Glu Gly Val  Glu Ser Ser 
    2015                 2020                 2025             


Glu Lys  Leu Asn Ser Ser Phe  Pro Ser Ile His Cys  Gly Ser Trp 
    2030                 2035                 2040             


Ala Glu  Xaa Xaa Pro Gly Gly  Gly Gly Ser Ser Ala  Ala Arg Arg 
    2045                 2050                 2055             


Val Arg  Pro Val Ser Leu Met  Val Pro Ser Gln Ala  Gly Ala Pro 
    2060                 2065                 2070             


Gly Arg  Gln Phe His Gly Ser  Ala Ser Ser Leu Val  Glu Ala Val 
    2075                 2080                 2085             


Leu Ile  Ser Glu Gly Leu Gly  Gln Phe Ala Gln Asp  Pro Lys Phe 
    2090                 2095                 2100             


Ile Glu  Val Xaa Xaa Gln Glu  Leu Ala Asp Ala Cys  Asp Met Xaa 
    2105                 2110                 2115             


Ile Glu  Glu Met Glu Ser Ala  Ala Asp Asn Ile Leu  Ser Gly Gly 
    2120                 2125                 2130             


Ala Pro  Gln Ser Pro Asn Gly  Ala Leu Leu Pro Phe  Val Asn Cys 
    2135                 2140                 2145             


Arg Asp  Ala Gly Gln Asp Arg  Ala Gly Gly Glu Glu  Asp Ala Gly 
    2150                 2155                 2160             


Cys Val  Arg Ala Arg Gly Arg  Pro Ser Glu Glu Glu  Leu Gln Asp 
    2165                 2170                 2175             


Ser Arg  Val Tyr Val Ser Ser  Leu 
    2180                 2185     


<210> 4673
<211> 2209
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1561)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1614)..(1614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1674)..(1674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1723)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1752)..(1752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1826)..(1826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1855)..(1855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1880)..(1880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1902)..(1902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1907)..(1907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1916)..(1916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1927)..(1927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1941)..(1941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1989)..(1989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2025)..(2025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2029)..(2029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2042)..(2042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2069)..(2070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2130)..(2131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2141)..(2141)
<223> Selenocysteine

<400> 4673
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr 
    370                 375                 380                 


Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Xaa Xaa Ile Phe 
    930                 935                 940                 


Xaa Ile Glu Ile Ala Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Xaa  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Xaa Glu Val Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Xaa Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Xaa Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Xaa Leu Leu  Trp Xaa Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Xaa  Xaa Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Xaa Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Xaa Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Xaa Glu Gly 
    1430                 1435                 1440             


Glu Xaa  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Xaa Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Xaa Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Xaa  Val Met Phe Asn Ala  Xaa Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Xaa Ala Leu  Arg Ile Lys Xaa Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Xaa Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Xaa Val  Gly Lys Phe Tyr Ala  Xaa Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Xaa Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Xaa Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Gly Arg  Ser Ala Phe Pro Gln  Xaa Phe Xaa Xaa Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly Asp Xaa  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Xaa Phe Xaa Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Xaa Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Xaa 
    1760                 1765                 1770             


Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly Tyr Pro  Ser Xaa Val 
    1775                 1780                 1785             


Ser Xaa  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg 
    1790                 1795                 1800             


Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser Asn Arg  Met His Cys 
    1805                 1810                 1815             


Cys Asp  Met Leu Asp Gly Gly  Xaa Phe Pro Pro Ala  Leu Gly Pro 
    1820                 1825                 1830             


Arg Arg  Ala Pro Pro Cys Leu  His Gln Gln Leu Gln  Gly Ser Leu 
    1835                 1840                 1845             


Ala Gly  Leu Arg Glu Asp Xaa  Pro Cys Ile Val Pro  Gly His Ala 
    1850                 1855                 1860             


Ser Leu  Cys Cys Ser Ser Arg  Val Gly Glu Trp Leu  Pro Ala Gly 
    1865                 1870                 1875             


Cys Xaa  Ala Pro Gln His Ala  Arg Cys His Ser Arg  Glu Ser Gln 
    1880                 1885                 1890             


Ala Ala  Met Ala Gly Gln Glu  Glu Xaa Ser Gln Asp  Glu Xaa Tyr 
    1895                 1900                 1905             


Glu Val  Lys Met Asn His Asp  Xaa Glu Ala Cys Ser  Glu Pro Ser 
    1910                 1915                 1920             


Leu Leu  Ser Xaa Glu Met Leu  Ser Tyr Gln Asp Asp  Glu Asn Arg 
    1925                 1930                 1935             


Gln Leu  Xaa Leu Pro Glu Glu  Asp Lys Arg Asp Ile  Arg Gln Ser 
    1940                 1945                 1950             


Pro Lys  Arg Gly Phe Leu Arg  Ser Ala Ser Leu Gly  Arg Arg Ala 
    1955                 1960                 1965             


Ser Phe  His Leu Glu Cys Leu  Lys Arg Gln Lys Asp  Arg Gly Gly 
    1970                 1975                 1980             


Asp Ile  Ser Gln Lys Xaa Val  Leu Pro Leu His Leu  Val His His 
    1985                 1990                 1995             


Gln Ala  Leu Ala Val Ala Gly  Leu Ser Pro Leu Leu  Gln Arg Ser 
    2000                 2005                 2010             


His Ser  Pro Ala Ser Phe Pro  Arg Pro Phe Ala Xaa  Pro Pro Ala 
    2015                 2020                 2025             


Xaa Pro  Gly Ser Arg Gly Trp  Pro Pro Gln Pro Val  Pro Xaa Leu 
    2030                 2035                 2040             


Arg Leu  Glu Gly Val Glu Ser  Ser Glu Lys Leu Asn  Ser Ser Phe 
    2045                 2050                 2055             


Pro Ser  Ile His Cys Gly Ser  Trp Ala Glu Xaa Xaa  Pro Gly Gly 
    2060                 2065                 2070             


Gly Gly  Ser Ser Ala Ala Arg  Arg Val Arg Pro Val  Ser Leu Met 
    2075                 2080                 2085             


Val Pro  Ser Gln Ala Gly Ala  Pro Gly Arg Gln Phe  His Gly Ser 
    2090                 2095                 2100             


Ala Ser  Ser Leu Val Glu Ala  Val Leu Ile Ser Glu  Gly Leu Gly 
    2105                 2110                 2115             


Gln Phe  Ala Gln Asp Pro Lys  Phe Ile Glu Val Xaa  Xaa Gln Glu 
    2120                 2125                 2130             


Leu Ala  Asp Ala Cys Asp Met  Xaa Ile Glu Glu Met  Glu Ser Ala 
    2135                 2140                 2145             


Ala Asp  Asn Ile Leu Ser Gly  Gly Ala Pro Gln Ser  Pro Asn Gly 
    2150                 2155                 2160             


Ala Leu  Leu Pro Phe Val Asn  Cys Arg Asp Ala Gly  Gln Asp Arg 
    2165                 2170                 2175             


Ala Gly  Gly Glu Glu Asp Ala  Gly Cys Val Arg Ala  Arg Gly Arg 
    2180                 2185                 2190             


Pro Ser  Glu Glu Glu Leu Gln  Asp Ser Arg Val Tyr  Val Ser Ser 
    2195                 2200                 2205             


Leu 
    


<210> 4674
<211> 2209
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1561)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1614)..(1614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1674)..(1674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1723)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1752)..(1752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1826)..(1826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1855)..(1855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1880)..(1880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1902)..(1902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1907)..(1907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1916)..(1916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1927)..(1927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1941)..(1941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1989)..(1989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2025)..(2025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2029)..(2029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2042)..(2042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2069)..(2070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2130)..(2131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2141)..(2141)
<223> Selenocysteine

<400> 4674
Met Val Asn Glu Asn Xaa Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Xaa Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Xaa Ile Ser Xaa Val Ser Ser Xaa Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Xaa Xaa 
                85                  90                  95      


Ala Xaa Arg Pro Pro Arg Ala Leu Leu Cys Leu Xaa Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Xaa Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Xaa Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Xaa Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Xaa Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Xaa 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Xaa Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val 
        355                 360                 365             


Leu Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr 
    370                 375                 380                 


Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Xaa Glu Val Gln Asp Xaa Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Xaa Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Ile Leu Val Glu Xaa 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Xaa Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Xaa Arg Arg Ser Xaa 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Xaa Val Phe Gln Ile Leu Xaa 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Xaa Xaa Ile Phe 
    930                 935                 940                 


Xaa Ile Glu Ile Ala Leu Lys Met Xaa Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Xaa Ile Gly  Asn Ile Val Ile Val  Xaa Xaa Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Xaa Cys Ser Asp  Ser Ser Lys Gln Xaa  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Xaa  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Xaa Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Xaa Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Xaa 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Xaa Gly  Leu Phe Xaa 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys Gly Tyr 
    1265                 1270                 1275             


Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe Leu Ile  Val Ile Gly 
    1280                 1285                 1290             


Ser Ile  Ile Asp Val Ile Leu  Ser Glu Xaa Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Xaa Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Xaa Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Xaa Leu Leu  Trp Xaa Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Xaa  Xaa Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Xaa Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Xaa Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Xaa Glu Gly 
    1430                 1435                 1440             


Glu Xaa  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Xaa Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Xaa Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Xaa  Val Met Phe Asn Ala  Xaa Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Xaa Ala Leu  Arg Ile Lys Xaa Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Xaa Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Xaa Val  Gly Lys Phe Tyr Ala  Xaa Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Xaa Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Xaa Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Gly Arg  Ser Ala Phe Pro Gln  Xaa Phe Xaa Xaa Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly Asp Xaa  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Xaa Phe Xaa Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Xaa Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Xaa 
    1760                 1765                 1770             


Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly Tyr Pro  Ser Xaa Val 
    1775                 1780                 1785             


Ser Xaa  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg 
    1790                 1795                 1800             


Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser Asn Arg  Met His Cys 
    1805                 1810                 1815             


Cys Asp  Met Leu Asp Gly Gly  Xaa Phe Pro Pro Ala  Leu Gly Pro 
    1820                 1825                 1830             


Arg Arg  Ala Pro Pro Cys Leu  His Gln Gln Leu Gln  Gly Ser Leu 
    1835                 1840                 1845             


Ala Gly  Leu Arg Glu Asp Xaa  Pro Cys Ile Val Pro  Gly His Ala 
    1850                 1855                 1860             


Ser Leu  Cys Cys Ser Ser Arg  Val Gly Glu Trp Leu  Pro Ala Gly 
    1865                 1870                 1875             


Cys Xaa  Ala Pro Gln His Ala  Arg Cys His Ser Arg  Glu Ser Gln 
    1880                 1885                 1890             


Ala Ala  Met Ala Gly Gln Glu  Glu Xaa Ser Gln Asp  Glu Xaa Tyr 
    1895                 1900                 1905             


Glu Val  Lys Met Asn His Asp  Xaa Glu Ala Cys Ser  Glu Pro Ser 
    1910                 1915                 1920             


Leu Leu  Ser Xaa Glu Met Leu  Ser Tyr Gln Asp Asp  Glu Asn Arg 
    1925                 1930                 1935             


Gln Leu  Xaa Leu Pro Glu Glu  Asp Lys Arg Asp Ile  Arg Gln Ser 
    1940                 1945                 1950             


Pro Lys  Arg Gly Phe Leu Arg  Ser Ala Ser Leu Gly  Arg Arg Ala 
    1955                 1960                 1965             


Ser Phe  His Leu Glu Cys Leu  Lys Arg Gln Lys Asp  Arg Gly Gly 
    1970                 1975                 1980             


Asp Ile  Ser Gln Lys Xaa Val  Leu Pro Leu His Leu  Val His His 
    1985                 1990                 1995             


Gln Ala  Leu Ala Val Ala Gly  Leu Ser Pro Leu Leu  Gln Arg Ser 
    2000                 2005                 2010             


His Ser  Pro Ala Ser Phe Pro  Arg Pro Phe Ala Xaa  Pro Pro Ala 
    2015                 2020                 2025             


Xaa Pro  Gly Ser Arg Gly Trp  Pro Pro Gln Pro Val  Pro Xaa Leu 
    2030                 2035                 2040             


Arg Leu  Glu Gly Val Glu Ser  Ser Glu Lys Leu Asn  Ser Ser Phe 
    2045                 2050                 2055             


Pro Ser  Ile His Cys Gly Ser  Trp Ala Glu Xaa Xaa  Pro Gly Gly 
    2060                 2065                 2070             


Gly Gly  Ser Ser Ala Ala Arg  Arg Val Arg Pro Val  Ser Leu Met 
    2075                 2080                 2085             


Val Pro  Ser Gln Ala Gly Ala  Pro Gly Arg Gln Phe  His Gly Ser 
    2090                 2095                 2100             


Ala Ser  Ser Leu Val Glu Ala  Val Leu Ile Ser Glu  Gly Leu Gly 
    2105                 2110                 2115             


Gln Phe  Ala Gln Asp Pro Lys  Phe Ile Glu Val Xaa  Xaa Gln Glu 
    2120                 2125                 2130             


Leu Ala  Asp Ala Cys Asp Met  Xaa Ile Glu Glu Met  Glu Ser Ala 
    2135                 2140                 2145             


Ala Asp  Asn Ile Leu Ser Gly  Gly Ala Pro Gln Ser  Pro Asn Gly 
    2150                 2155                 2160             


Ala Leu  Leu Pro Phe Val Asn  Cys Arg Asp Ala Gly  Gln Asp Arg 
    2165                 2170                 2175             


Ala Gly  Gly Glu Glu Asp Ala  Gly Cys Val Arg Ala  Arg Gly Arg 
    2180                 2185                 2190             


Pro Ser  Glu Glu Glu Leu Gln  Asp Ser Arg Val Tyr  Val Ser Ser 
    2195                 2200                 2205             


Leu 
    


<210> 4675
<211> 243
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<400> 4675
Xaa Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu Phe 
1               5                   10                  15      


Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val 
            20                  25                  30          


Asp Asn Leu Ala Asp Ala Glu Ser Leu Xaa Ser Ala Gln Lys Glu Glu 
        35                  40                  45              


Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Xaa Ala Ser Pro Glu 
    50                  55                  60                  


Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys Glu 
65                  70                  75                  80  


Glu Lys Ile Glu Leu Lys Ser Ile Xaa Ala Asp Gly Glu Ser Pro Pro 
                85                  90                  95      


Ala Xaa Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu Asp 
            100                 105                 110         


Lys Ser Pro Tyr Pro Asn Pro Glu Xaa Xaa Gly Glu Glu Asp Glu Glu 
        115                 120                 125             


Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu Leu 
    130                 135                 140                 


His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe Phe 
145                 150                 155                 160 


Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile Val 
                165                 170                 175     


Asn Asp Xaa Ile Phe Xaa Asn Leu Ile Leu Phe Phe Ile Leu Leu Ser 
            180                 185                 190         


Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Xaa Ser Phe Arg 
        195                 200                 205             


Asn His Val Cys Ile Ala Cys Val Phe Cys Xaa Pro Ser Pro Trp Gly 
    210                 215                 220                 


Cys Ala Arg Pro Xaa Ala Ser Val Ala Asp Ile Ile Val Gln Ser Gly 
225                 230                 235                 240 


Ala Gln Phe 
            


<210> 4676
<211> 1854
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (996)..(996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1200)..(1200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1255)..(1255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1277)..(1277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1339)..(1339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1363)..(1363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1397)..(1397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1399)..(1400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1417)..(1417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1447)..(1447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1497)..(1497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1502)..(1502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1515)..(1515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1552)..(1552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1671)..(1671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1676)..(1676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1680)..(1680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1687)..(1687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1691)..(1691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1719)..(1719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1728)..(1728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1730)..(1730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1735)..(1735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1777)..(1777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1788)..(1788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1798)..(1798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1852)..(1853)
<223> Selenocysteine

<400> 4676
Ala Asn Gly Xaa Glu Cys Arg Ser Gly Trp Val Gly Pro Asn Gly Gly 
1               5                   10                  15      


Ile Xaa Asn Phe Asp Asn Phe Ala Phe Ala Met Leu Xaa Val Phe Gln 
            20                  25                  30          


Cys Ile Xaa Met Glu Gly Trp Xaa Asp Val Leu Tyr Trp Met Asn Asp 
        35                  40                  45              


Ala Met Gly Phe Glu Leu Pro Trp Val Tyr Phe Val Ser Leu Val Ile 
    50                  55                  60                  


Phe Gly Ser Phe Phe Val Leu Asn Leu Val Leu Gly Val Leu Ser Gly 
65                  70                  75                  80  


Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys Ala Arg Gly Asp Phe Gln 
                85                  90                  95      


Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu Asp Leu Lys Gly Tyr Leu 
            100                 105                 110         


Asp Trp Ile Xaa Gln Ala Glu Asp Ile Asp Pro Glu Asn Glu Glu Glu 
        115                 120                 125             


Gly Gly Glu Glu Gly Lys Arg Asn Xaa Ser Met Pro Xaa Ser Glu Xaa 
    130                 135                 140                 


Glu Ser Val Asn Xaa Glu Asn Val Ser Gly Glu Gly Glu Asn Arg Gly 
145                 150                 155                 160 


Cys Cys Gly Ser Leu Trp Cys Trp Trp Arg Arg Arg Gly Ala Ala Lys 
                165                 170                 175     


Ala Gly Pro Ser Gly Cys Arg Arg Trp Gly Gln Ala Ile Ser Lys Ser 
            180                 185                 190         


Lys Leu Ser Arg Arg Trp Arg Arg Trp Asn Arg Phe Asn Arg Arg Arg 
        195                 200                 205             


Cys Arg Ala Ala Val Lys Ser Val Xaa Phe Tyr Trp Leu Val Ile Val 
    210                 215                 220                 


Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ser Ser Glu His Tyr Asn Gln 
225                 230                 235                 240 


Pro Asp Trp Leu Xaa Gln Ile Gln Asp Ile Ala Asn Lys Val Leu Leu 
                245                 250                 255     


Ala Leu Phe Xaa Cys Glu Met Leu Val Lys Met Tyr Ser Leu Gly Leu 
            260                 265                 270         


Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp Cys Phe Val Val 
        275                 280                 285             


Cys Gly Gly Ile Xaa Glu Xaa Ile Leu Val Glu Leu Glu Ile Met Ser 
    290                 295                 300                 


Pro Leu Gly Ile Ser Val Phe Arg Cys Val Arg Leu Leu Arg Ile Phe 
305                 310                 315                 320 


Lys Val Xaa Arg His Trp Xaa Ser Leu Ser Asn Leu Val Ala Ser Leu 
                325                 330                 335     


Leu Asn Ser Met Lys Ser Ile Ala Ser Leu Leu Leu Leu Leu Phe Leu 
            340                 345                 350         


Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe Gly Gly Lys 
        355                 360                 365             


Phe Asn Phe Asp Glu Xaa Gln Xaa Lys Arg Ser Xaa Phe Asp Asn Phe 
    370                 375                 380                 


Pro Gln Ala Leu Leu Xaa Val Phe Gln Ile Leu Xaa Gly Glu Asp Trp 
385                 390                 395                 400 


Asn Ala Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly Pro Ser Ser 
                405                 410                 415     


Ser Gly Met Ile Val Cys Ile Tyr Phe Ile Ile Leu Phe Ile Cys Gly 
            420                 425                 430         


Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu 
        435                 440                 445             


Ala Asp Ala Glu Ser Leu Asn Xaa Ala Gln Lys Glu Glu Ala Glu Glu 
    450                 455                 460                 


Lys Glu Arg Lys Lys Ile Ala Arg Lys Glu Ser Leu Glu Asn Lys Lys 
465                 470                 475                 480 


Asn Asn Lys Pro Glu Val Asn Gln Ile Ala Asn Ser Asp Asn Lys Val 
                485                 490                 495     


Xaa Ile Asp Asp Tyr Arg Glu Glu Asp Glu Asp Lys Asp Pro Tyr Pro 
            500                 505                 510         


Pro Cys Asp Val Pro Val Gly Glu Glu Glu Glu Glu Glu Glu Glu Asp 
        515                 520                 525             


Glu Pro Glu Val Pro Ala Gly Pro Arg Pro Arg Arg Ile Ser Glu Leu 
    530                 535                 540                 


Asn Met Lys Glu Lys Ile Ala Pro Ile Pro Glu Gly Ser Ala Phe Phe 
545                 550                 555                 560 


Ile Leu Ser Lys Xaa Asn Pro Ile Arg Val Gly Cys His Lys Leu Ile 
                565                 570                 575     


Asn His His Ile Phe Xaa Asn Leu Ile Leu Val Phe Ile Met Leu Ser 
            580                 585                 590         


Ser Ala Ala Leu Ala Ala Glu Asp Pro Ile Arg Ser His Ser Phe Arg 
        595                 600                 605             


Asn Xaa Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Xaa Ala Ile Phe Xaa 
    610                 615                 620                 


Val Glu Ile Leu Leu Lys Met Xaa Xaa Phe Gly Ala Phe Leu His Lys 
625                 630                 635                 640 


Gly Ala Phe Cys Arg Asn Tyr Phe Asn Leu Leu Asp Met Leu Val Val 
                645                 650                 655     


Gly Val Ser Leu Val Ser Phe Gly Ile Gln Ser Ser Ala Ile Ser Val 
            660                 665                 670         


Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu Arg Ala Ile 
        675                 680                 685             


Asn Arg Ala Lys Gly Leu Lys His Val Val Gln Cys Val Phe Val Ala 
    690                 695                 700                 


Ile Arg Xaa Ile Gly Asn Ile Met Ile Val Xaa Xaa Leu Leu Gln Phe 
705                 710                 715                 720 


Met Phe Ala Cys Ile Gly Val Gln Leu Phe Lys Gly Lys Phe Tyr Arg 
                725                 730                 735     


Cys Xaa Asp Glu Ala Lys Ser Asn Pro Glu Glu Cys Arg Gly Leu Phe 
            740                 745                 750         


Ile Leu Tyr Lys Asp Gly Asp Val Asp Ser Pro Val Val Arg Glu Arg 
        755                 760                 765             


Ile Trp Gln Asn Ser Asp Phe Asn Phe Asp Asn Val Leu Ser Ala Met 
    770                 775                 780                 


Met Ala Leu Phe Xaa Val Ser Xaa Phe Glu Gly Trp Pro Ala Leu Leu 
785                 790                 795                 800 


Tyr Lys Ala Ile Asp Ser Asn Gly Glu Asn Ile Gly Pro Ile Tyr Asn 
                805                 810                 815     


His Arg Val Glu Ile Ser Ile Phe Phe Ile Ile Tyr Ile Ile Ile Val 
            820                 825                 830         


Ala Phe Phe Met Met Asn Ile Phe Val Gly Phe Val Ile Val Xaa Phe 
        835                 840                 845             


Gln Glu Gln Gly Glu Lys Glu Tyr Lys Asn Cys Glu Leu Asp Lys Asn 
    850                 855                 860                 


Gln Arg Gln Cys Val Glu Tyr Ala Leu Lys Ala Arg Pro Leu Arg Arg 
865                 870                 875                 880 


Tyr Ile Pro Lys Asn Pro Tyr Gln Tyr Lys Phe Trp Tyr Val Val Asn 
                885                 890                 895     


Ser Ser Pro Phe Glu Tyr Met Met Phe Val Leu Ile Met Leu Asn Xaa 
            900                 905                 910         


Leu Cys Leu Ala Met Gln His Tyr Glu Gln Ser Lys Met Phe Asn Asp 
        915                 920                 925             


Ala Met Asp Ile Leu Asn Met Val Phe Xaa Gly Val Phe Xaa Val Glu 
    930                 935                 940                 


Met Val Leu Lys Val Ile Ala Phe Lys Pro Lys His Tyr Phe Xaa Asp 
945                 950                 955                 960 


Ala Trp Asn Xaa Phe Asp Ala Leu Ile Val Val Gly Ser Val Val Asp 
                965                 970                 975     


Ile Ala Ile Xaa Glu Val Asn Pro Xaa Glu Ser Glu Asn Val Pro Val 
            980                 985                 990         


Pro Xaa Ala Xaa Pro Gly Asn Ser  Glu Glu Ser Asn Arg  Ile Ser Ile 
        995                 1000                 1005             


Xaa Phe  Phe Arg Leu Phe Arg  Val Met Arg Leu Val  Lys Leu Leu 
    1010                 1015                 1020             


Ser Arg  Gly Glu Gly Ile Arg  Xaa Leu Leu Trp Xaa  Phe Ile Lys 
    1025                 1030                 1035             


Ser Phe  Gln Ala Leu Pro Tyr  Val Ala Leu Leu Ile  Ala Met Leu 
    1040                 1045                 1050             


Phe Phe  Ile Tyr Ala Val Ile  Gly Met Gln Met Phe  Gly Lys Val 
    1055                 1060                 1065             


Ala Met  Arg Asp Asn Asn Gln  Ile Asn Arg Asn Asn  Asn Phe Gln 
    1070                 1075                 1080             


Xaa Phe  Pro Gln Ala Val Leu  Leu Leu Phe Arg Cys  Ala Xaa Gly 
    1085                 1090                 1095             


Glu Ala  Trp Gln Glu Ile Met  Leu Ala Cys Leu Pro  Gly Lys Leu 
    1100                 1105                 1110             


Cys Asp  Pro Glu Ser Asp Tyr  Asn Pro Gly Glu Glu  Tyr Xaa Cys 
    1115                 1120                 1125             


Gly Ser  Asn Phe Ala Ile Val  Tyr Phe Ile Ser Phe  Tyr Met Leu 
    1130                 1135                 1140             


Cys Ala  Phe Leu Ile Ile Asn  Leu Phe Val Ala Val  Ile Met Asp 
    1145                 1150                 1155             


Asn Phe  Asp Tyr Leu Xaa Arg  Asp Trp Ser Ile Leu  Gly Pro His 
    1160                 1165                 1170             


His Leu  Asp Glu Phe Lys Arg  Ile Trp Ser Glu Tyr  Asp Pro Glu 
    1175                 1180                 1185             


Ala Lys  Gly Arg Ile Lys His  Leu Asp Val Val Xaa  Leu Leu Arg 
    1190                 1195                 1200             


Arg Ile  Gln Pro Pro Leu Gly  Phe Gly Lys Leu Cys  Pro His Arg 
    1205                 1210                 1215             


Val Ala  Cys Lys Arg Leu Val  Ala Met Asn Met Pro  Leu Asn Ser 
    1220                 1225                 1230             


Asp Gly  Xaa Val Met Phe Asn  Ala Xaa Leu Phe Ala  Leu Val Arg 
    1235                 1240                 1245             


Xaa Ala  Leu Lys Ile Lys Xaa  Glu Gly Asn Leu Glu  Gln Ala Asn 
    1250                 1255                 1260             


Glu Glu  Leu Arg Ala Val Ile  Lys Lys Ile Trp Lys  Lys Xaa Ser 
    1265                 1270                 1275             


Met Lys  Leu Leu Asp Gln Val  Val Pro Pro Ala Gly  Asp Asp Glu 
    1280                 1285                 1290             


Val Xaa  Val Gly Lys Phe Tyr  Ala Xaa Phe Leu Ile  Gln Asp Tyr 
    1295                 1300                 1305             


Phe Arg  Lys Phe Lys Lys Arg  Lys Glu Gln Gly Leu  Val Gly Lys 
    1310                 1315                 1320             


Tyr Pro  Ala Lys Asn Xaa Xaa  Ile Ala Leu Gln Ala  Gly Leu Arg 
    1325                 1330                 1335             


Xaa Leu  His Asp Ile Gly Pro  Glu Ile Arg Arg Ala  Ile Ser Cys 
    1340                 1345                 1350             


Asp Leu  Gln Asp Asp Glu Pro  Glu Glu Xaa Lys Arg  Glu Glu Glu 
    1355                 1360                 1365             


Asp Asp  Val Phe Lys Arg Asn  Gly Ala Leu Leu Gly  Asn His Val 
    1370                 1375                 1380             


Asn His  Val Asn Ser Asp Arg  Arg Asp Ser Leu Gln  Gln Xaa Asn 
    1385                 1390                 1395             


Xaa Xaa  His Arg Pro Leu His  Val Gln Arg Pro Ser  Ile Pro Pro 
    1400                 1405                 1410             


Ala Ser  Asp Xaa Glu Lys Pro  Leu Phe Pro Pro Ala  Gly Asn Ser 
    1415                 1420                 1425             


Val Cys  His Asn His His Asn  His Asn Ser Ile Gly  Lys Gln Val 
    1430                 1435                 1440             


Pro Xaa  Ser Xaa Asn Ala Asn  Leu Asn Asn Ala Asn  Met Ser Lys 
    1445                 1450                 1455             


Ala Ala  His Gly Lys Arg Pro  Ser Ile Gly Asn Leu  Glu His Val 
    1460                 1465                 1470             


Ser Glu  Asn Gly His His Ser  Ser His Lys His Asp  Arg Glu Pro 
    1475                 1480                 1485             


Gln Arg  Arg Ser Ser Val Lys  Arg Xaa Arg Tyr Tyr  Glu Xaa Tyr 
    1490                 1495                 1500             


Ile Arg  Ser Asp Ser Gly Asp  Glu Gln Leu Pro Xaa  Ile Cys Arg 
    1505                 1510                 1515             


Glu Asp  Pro Glu Ile His Gly  Tyr Phe Arg Asp Pro  His Cys Leu 
    1520                 1525                 1530             


Gly Glu  Gln Glu Tyr Phe Ser  Ser Glu Glu Cys Tyr  Glu Asp Asp 
    1535                 1540                 1545             


Ser Ser  Pro Xaa Trp Ser Arg  Gln Asn Tyr Gly Tyr  Tyr Ser Arg 
    1550                 1555                 1560             


Tyr Pro  Gly Arg Asn Ile Asp  Ser Glu Arg Pro Arg  Gly Tyr His 
    1565                 1570                 1575             


His Pro  Gln Gly Phe Leu Glu  Asp Asp Asp Ser Pro  Val Cys Tyr 
    1580                 1585                 1590             


Asp Ser  Arg Arg Ser Pro Arg  Arg Arg Leu Leu Pro  Pro Xaa Pro 
    1595                 1600                 1605             


Ala Ser  His Arg Arg Ser Ser  Phe Asn Phe Glu Cys  Leu Arg Arg 
    1610                 1615                 1620             


Gln Ser  Ser Gln Glu Glu Val  Pro Ser Ser Pro Ile  Phe Pro His 
    1625                 1630                 1635             


Arg Xaa  Ala Leu Pro Leu His  Leu Met Gln Gln Gln  Ile Met Ala 
    1640                 1645                 1650             


Val Ala  Gly Leu Asp Ser Ser  Lys Ala Gln Lys Tyr  Ser Pro Ser 
    1655                 1660                 1665             


His Ser  Xaa Arg Ser Trp Ala  Xaa Pro Pro Ala Xaa  Pro Pro Tyr 
    1670                 1675                 1680             


Arg Asp  Trp Xaa Pro Cys Tyr  Xaa Pro Leu Ile Gln  Val Glu Gln 
    1685                 1690                 1695             


Ser Glu  Ala Leu Asp Gln Val  Asn Gly Ser Leu Pro  Ser Leu His 
    1700                 1705                 1710             


Arg Ser  Ser Trp Tyr Xaa Asp  Glu Pro Asp Ile Ser  Tyr Arg Xaa 
    1715                 1720                 1725             


Phe Xaa  Pro Ala Ser Leu Xaa  Val Pro Ser Ser Phe  Arg Asn Lys 
    1730                 1735                 1740             


Asn Ser  Asp Lys Gln Arg Ser  Ala Asp Ser Leu Val  Glu Ala Val 
    1745                 1750                 1755             


Leu Ile  Ser Glu Gly Leu Gly  Arg Tyr Ala Arg Asp  Pro Lys Phe 
    1760                 1765                 1770             


Val Ser  Ala Xaa Lys His Glu  Ile Ala Asp Ala Cys  Asp Leu Xaa 
    1775                 1780                 1785             


Ile Asp  Glu Met Glu Ser Ala  Ala Ser Xaa Leu Leu  Asn Gly Asn 
    1790                 1795                 1800             


Val Arg  Pro Arg Ala Asn Gly  Asp Val Gly Pro Leu  Ser His Arg 
    1805                 1810                 1815             


Gln Asp  Tyr Glu Leu Gln Asp  Phe Gly Pro Gly Tyr  Ser Asp Glu 
    1820                 1825                 1830             


Glu Pro  Asp Pro Gly Arg Asp  Glu Glu Asp Leu Ala  Asp Glu Met 
    1835                 1840                 1845             


Ile Cys  Ile Xaa Xaa Leu 
    1850                 


<210> 4677
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 4677
Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Arg Val Xaa Val Ala 
1               5                   10                  15      


Asp Leu Leu Lys Glu Asp Lys Lys Lys Lys Lys Phe Cys Cys Phe Arg 
            20                  25                  30          


Gln Arg Arg Ala Lys Asp His Ala Ser Met Pro Xaa Ser Glu Xaa Glu 
        35                  40                  45              


Ser Val Asn Xaa Glu Asn Val Ser Gly Glu Gly Glu Asn Arg Gly Cys 
    50                  55                  60                  


Cys Gly Ser Leu Trp Cys Trp Trp 
65                  70          


<210> 4678
<211> 223
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<400> 4678
Phe Phe Met Met Asn Ile Phe Val Gly Phe Val Ile Val Xaa Phe Gln 
1               5                   10                  15      


Glu Gln Gly Glu Lys Glu Tyr Lys Asn Cys Glu Leu Asp Lys Asn Gln 
            20                  25                  30          


Arg Gln Cys Val Glu Tyr Ala Leu Lys Ala Arg Pro Leu Arg Arg Tyr 
        35                  40                  45              


Ile Pro Lys Asn Pro Tyr Gln Tyr Lys Phe Trp Tyr Val Val Asn Ser 
    50                  55                  60                  


Ser Pro Phe Glu Tyr Met Met Phe Val Leu Ile Met Leu Asn Xaa Leu 
65                  70                  75                  80  


Cys Leu Ala Met Gln His Tyr Glu Gln Ser Lys Met Phe Asn Asp Ala 
                85                  90                  95      


Met Asp Ile Leu Asn Met Val Phe Xaa Gly Val Phe Xaa Val Glu Met 
            100                 105                 110         


Val Leu Lys Val Ile Ala Phe Lys Pro Lys Ala Leu Pro Tyr Val Ala 
        115                 120                 125             


Leu Leu Ile Ala Met Leu Phe Phe Ile Tyr Ala Val Ile Gly Met Gln 
    130                 135                 140                 


Met Phe Gly Lys Val Ala Met Arg Asp Asn Asn Gln Ile Asn Arg Asn 
145                 150                 155                 160 


Asn Asn Phe Gln Xaa Phe Pro Gln Ala Val Leu Leu Leu Phe Arg Cys 
                165                 170                 175     


Ala Xaa Gly Glu Ala Trp Gln Glu Ile Met Leu Ala Cys Leu Pro Gly 
            180                 185                 190         


Lys Leu Cys Asp Pro Glu Ser Asp Tyr Asn Pro Gly Glu Glu Tyr Xaa 
        195                 200                 205             


Cys Gly Ser Asn Phe Ala Ile Val Tyr Phe Ile Ser Phe Tyr Met 
    210                 215                 220             


<210> 4679
<211> 2170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1120)..(1120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1123)..(1123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1243)..(1243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1273)..(1273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1325)..(1325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1347)..(1347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1400)..(1400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1413)..(1413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1443)..(1443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1480)..(1480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1516)..(1516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1552)..(1552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1558)..(1558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1565)..(1565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1571)..(1571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1593)..(1593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1611)..(1611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1618)..(1618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1645)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1655)..(1655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1679)..(1679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1713)..(1713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1715)..(1716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1733)..(1733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1763)..(1763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1813)..(1813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1818)..(1818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1831)..(1831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1868)..(1868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1923)..(1923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1956)..(1956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1987)..(1987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1992)..(1992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1996)..(1996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2003)..(2003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2007)..(2007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2035)..(2035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2044)..(2044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2046)..(2046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2051)..(2051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2093)..(2093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2104)..(2104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2114)..(2114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2168)..(2169)
<223> Selenocysteine

<400> 4679
Met Glu Met Asn Leu Pro Xaa Phe Ser Ser Asp Leu Ile Phe Ile Lys 
1               5                   10                  15      


Ser Xaa Met Tyr Gln Glu Ile Asp Ala Arg Tyr Lys Gly Lys Val Ile 
            20                  25                  30          


Ser Glu Ala Glu Xaa Lys Gly Tyr Phe Ser Leu Ala Phe Gly Glu Ala 
        35                  40                  45              


Asn Tyr Ala Arg Gly Xaa Arg Leu Pro Leu Ser Gly Glu Gly Pro Xaa 
    50                  55                  60                  


Ser Gln Pro Asn Ser Ser Lys Gln Xaa Val Leu Ser Trp Gln Ala Ala 
65                  70                  75                  80  


Ile Asp Ala Ala Arg Gln Ala Lys Ala Ala Gln Xaa Met Ser Xaa Ser 
                85                  90                  95      


Ala Pro Pro Pro Val Gly Ser Leu Ser Gln Arg Lys Arg Gln Gln Tyr 
            100                 105                 110         


Ala Lys Ser Lys Lys Gln Gly Asn Ser Ser Asn Ser Arg Pro Ala Arg 
        115                 120                 125             


Ala Leu Phe Cys Leu Ser Leu Asn Asn Pro Ile Arg Arg Ala Cys Ile 
    130                 135                 140                 


Ser Ile Val Glu Trp Lys Pro Phe Asp Ile Phe Ile Leu Leu Ala Ile 
145                 150                 155                 160 


Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr Ile Pro Phe Pro Glu Asp 
                165                 170                 175     


Asp Ser Asn Ser Xaa Asn His Asn Leu Glu Lys Val Glu Tyr Ala Phe 
            180                 185                 190         


Leu Ile Ile Phe Xaa Val Glu Xaa Phe Leu Lys Ile Ile Ala Tyr Gly 
        195                 200                 205             


Leu Leu Leu His Pro Asn Ala Tyr Val Arg Asn Gly Trp Asn Leu Leu 
    210                 215                 220                 


Asp Phe Val Ile Val Ile Val Gly Leu Phe Ser Val Ile Leu Glu Gln 
225                 230                 235                 240 


Leu Xaa Lys Glu Xaa Glu Gly Gly Asn His Ser Ser Gly Lys Ser Gly 
                245                 250                 255     


Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg Val Leu Arg Pro Leu 
            260                 265                 270         


Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val Val Leu Asn Ser Ile 
        275                 280                 285             


Ile Lys Ala Met Val Pro Leu Leu His Ile Ala Leu Leu Val Leu Phe 
    290                 295                 300                 


Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu Leu Phe Ile Gly Lys 
305                 310                 315                 320 


Met His Lys Xaa Cys Phe Phe Ala Asp Ser Asp Ile Val Ala Glu Glu 
                325                 330                 335     


Asp Pro Ala Pro Cys Ala Phe Ser Gly Asn Gly Arg Gln Cys Xaa Ala 
            340                 345                 350         


Asn Gly Xaa Glu Cys Arg Ser Gly Trp Val Gly Pro Asn Gly Gly Ile 
        355                 360                 365             


Xaa Asn Phe Asp Asn Phe Ala Phe Ala Met Leu Xaa Val Phe Gln Cys 
    370                 375                 380                 


Ile Xaa Met Glu Gly Trp Xaa Asp Val Leu Tyr Trp Val Asn Asp Ala 
385                 390                 395                 400 


Ile Gly Trp Glu Trp Pro Trp Val Tyr Phe Val Ser Leu Ile Ile Leu 
                405                 410                 415     


Gly Ser Phe Phe Val Leu Asn Leu Val Leu Gly Val Leu Ser Gly Glu 
            420                 425                 430         


Phe Ser Lys Glu Arg Glu Lys Ala Lys Ala Arg Gly Asp Phe Gln Lys 
        435                 440                 445             


Leu Arg Glu Lys Gln Gln Leu Glu Glu Asp Leu Lys Gly Tyr Leu Asp 
    450                 455                 460                 


Trp Ile Xaa Gln Ala Glu Asp Ile Asp Pro Glu Asn Glu Glu Glu Gly 
465                 470                 475                 480 


Gly Glu Glu Gly Lys Arg Asn Xaa Ser Met Pro Xaa Ser Glu Xaa Glu 
                485                 490                 495     


Ser Val Asn Xaa Glu Asn Val Ser Gly Glu Gly Glu Asn Arg Gly Cys 
            500                 505                 510         


Cys Gly Ser Leu Cys Gln Ala Ile Ser Lys Ser Lys Leu Ser Arg Arg 
        515                 520                 525             


Trp Arg Arg Trp Asn Arg Phe Asn Arg Arg Arg Cys Arg Ala Ala Val 
    530                 535                 540                 


Lys Ser Val Xaa Phe Tyr Trp Leu Val Ile Val Leu Val Phe Leu Asn 
545                 550                 555                 560 


Xaa Leu Xaa Ile Ser Ser Glu His Tyr Asn Gln Pro Asp Trp Leu Xaa 
                565                 570                 575     


Gln Ile Gln Asp Ile Ala Asn Lys Val Leu Leu Ala Leu Phe Xaa Cys 
            580                 585                 590         


Glu Met Leu Val Lys Met Tyr Ser Leu Gly Leu Gln Ala Tyr Phe Val 
        595                 600                 605             


Ser Leu Phe Asn Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Xaa 
    610                 615                 620                 


Glu Xaa Ile Leu Val Glu Leu Glu Ile Met Ser Pro Leu Gly Ile Ser 
625                 630                 635                 640 


Val Phe Arg Cys Val Arg Leu Leu Arg Ile Phe Lys Val Xaa Arg His 
                645                 650                 655     


Trp Xaa Ser Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Met Lys 
            660                 665                 670         


Ser Ile Ala Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe 
        675                 680                 685             


Ser Leu Leu Gly Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Glu 
    690                 695                 700                 


Xaa Gln Xaa Lys Arg Ser Xaa Phe Asp Asn Phe Pro Gln Ala Leu Leu 
705                 710                 715                 720 


Xaa Val Phe Gln Ile Leu Xaa Gly Glu Asp Trp Asn Ala Val Met Tyr 
                725                 730                 735     


Asp Gly Ile Met Ala Tyr Gly Gly Pro Ser Ser Ser Gly Met Ile Val 
            740                 745                 750         


Cys Ile Tyr Phe Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu 
        755                 760                 765             


Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asp Ala Glu Ser 
    770                 775                 780                 


Leu Asn Xaa Ala Gln Lys Glu Glu Ala Glu Glu Lys Glu Arg Lys Lys 
785                 790                 795                 800 


Ile Ala Arg Lys Glu Ser Leu Glu Asn Lys Lys Asn Asn Lys Pro Glu 
                805                 810                 815     


Val Asn Gln Ile Ala Asn Ser Asp Asn Lys Val Xaa Ile Asp Asp Tyr 
            820                 825                 830         


Arg Glu Glu Asp Glu Asp Lys Asp Pro Tyr Pro Pro Cys Asp Val Pro 
        835                 840                 845             


Val Gly Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Pro Glu Val Pro 
    850                 855                 860                 


Ala Gly Pro Arg Pro Arg Arg Ile Ser Glu Leu Asn Met Lys Glu Lys 
865                 870                 875                 880 


Ile Ala Pro Ile Pro Glu Gly Ser Ala Phe Phe Ile Leu Ser Lys Xaa 
                885                 890                 895     


Asn Pro Ile Arg Val Gly Cys His Lys Leu Ile Asn His His Ile Phe 
            900                 905                 910         


Xaa Asn Leu Ile Leu Val Phe Ile Met Leu Ser Ser Ala Ala Leu Ala 
        915                 920                 925             


Ala Glu Asp Pro Ile Arg Ser His Ser Phe Arg Asn Xaa Ile Leu Gly 
    930                 935                 940                 


Tyr Phe Asp Tyr Ala Phe Xaa Ala Ile Phe Xaa Val Glu Ile Leu Leu 
945                 950                 955                 960 


Lys Met Xaa Xaa Phe Gly Ala Phe Leu His Lys Gly Ala Phe Cys Arg 
                965                 970                 975     


Asn Tyr Phe Asn Leu Leu Asp Met Leu Val Val Gly Val Ser Leu Val 
            980                 985                 990         


Ser Phe Gly Ile Gln Ser Ser Ala  Ile Ser Val Val Lys  Ile Leu Arg 
        995                 1000                 1005             


Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala Ile Asn  Arg Ala Lys 
    1010                 1015                 1020             


Gly Leu  Lys His Val Val Gln  Cys Val Phe Val Ala  Ile Arg Xaa 
    1025                 1030                 1035             


Ile Gly  Asn Ile Met Ile Val  Xaa Xaa Leu Leu Gln  Phe Met Phe 
    1040                 1045                 1050             


Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly Lys Phe  Tyr Arg Cys 
    1055                 1060                 1065             


Xaa Asp  Glu Ala Lys Ser Asn  Pro Glu Glu Cys Arg  Gly Leu Phe 
    1070                 1075                 1080             


Ile Leu  Tyr Lys Asp Gly Asp  Val Asp Ser Pro Val  Val Arg Glu 
    1085                 1090                 1095             


Arg Ile  Trp Gln Asn Ser Asp  Phe Asn Phe Asp Asn  Val Leu Ser 
    1100                 1105                 1110             


Ala Met  Met Ala Leu Phe Xaa  Val Ser Xaa Phe Glu  Gly Trp Pro 
    1115                 1120                 1125             


Ala Leu  Leu Tyr Lys Ala Ile  Asp Ser Asn Gly Glu  Asn Ile Gly 
    1130                 1135                 1140             


Pro Ile  Tyr Asn His Arg Val  Glu Ile Ser Ile Phe  Phe Ile Ile 
    1145                 1150                 1155             


Tyr Ile  Ile Ile Val Ala Phe  Phe Met Met Asn Ile  Phe Val Gly 
    1160                 1165                 1170             


Phe Val  Ile Val Xaa Phe Gln  Glu Gln Gly Glu Lys  Glu Tyr Lys 
    1175                 1180                 1185             


Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln Cys Val  Glu Tyr Ala 
    1190                 1195                 1200             


Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile Pro Lys  Asn Pro Tyr 
    1205                 1210                 1215             


Gln Tyr  Lys Phe Trp Tyr Val  Val Asn Ser Ser Pro  Phe Glu Tyr 
    1220                 1225                 1230             


Met Met  Phe Val Leu Ile Met  Leu Asn Xaa Leu Cys  Leu Ala Met 
    1235                 1240                 1245             


Gln His  Tyr Glu Gln Ser Lys  Met Phe Asn Asp Ala  Met Asp Ile 
    1250                 1255                 1260             


Leu Asn  Met Val Phe Xaa Gly  Val Phe Xaa Val Glu  Met Val Leu 
    1265                 1270                 1275             


Lys Val  Ile Ala Phe Lys Pro  Lys Gly Tyr Phe Ser  Asp Ala Trp 
    1280                 1285                 1290             


Asn Xaa  Phe Asp Ser Leu Ile  Val Ile Gly Ser Ile  Ile Asp Val 
    1295                 1300                 1305             


Ala Leu  Ser Glu Ala Asp Asn  Ser Glu Glu Ser Asn  Arg Ile Ser 
    1310                 1315                 1320             


Ile Xaa  Phe Phe Arg Leu Phe  Arg Val Met Arg Leu  Val Lys Leu 
    1325                 1330                 1335             


Leu Ser  Arg Gly Glu Gly Ile  Arg Xaa Leu Leu Trp  Xaa Phe Ile 
    1340                 1345                 1350             


Lys Ser  Phe Gln Ala Leu Pro  Tyr Val Ala Leu Leu  Ile Ala Met 
    1355                 1360                 1365             


Leu Phe  Phe Ile Tyr Ala Val  Ile Gly Met Gln Met  Phe Gly Lys 
    1370                 1375                 1380             


Val Ala  Met Arg Asp Asn Asn  Gln Ile Asn Arg Asn  Asn Asn Phe 
    1385                 1390                 1395             


Gln Xaa  Phe Pro Gln Ala Val  Leu Leu Leu Phe Arg  Cys Ala Xaa 
    1400                 1405                 1410             


Gly Glu  Ala Trp Gln Glu Ile  Met Leu Ala Cys Leu  Pro Gly Lys 
    1415                 1420                 1425             


Leu Cys  Asp Pro Glu Ser Asp  Tyr Asn Pro Gly Glu  Glu Tyr Xaa 
    1430                 1435                 1440             


Cys Gly  Ser Asn Phe Ala Ile  Val Tyr Phe Ile Ser  Phe Tyr Met 
    1445                 1450                 1455             


Leu Cys  Ala Phe Leu Ile Ile  Asn Leu Phe Val Ala  Val Ile Met 
    1460                 1465                 1470             


Asp Asn  Phe Asp Tyr Leu Xaa  Arg Asp Trp Ser Ile  Leu Gly Pro 
    1475                 1480                 1485             


His His  Leu Asp Glu Phe Lys  Arg Ile Trp Ser Glu  Tyr Asp Pro 
    1490                 1495                 1500             


Glu Ala  Lys Gly Arg Ile Lys  His Leu Asp Val Val  Xaa Leu Leu 
    1505                 1510                 1515             


Arg Arg  Ile Gln Pro Pro Leu  Gly Phe Gly Lys Leu  Cys Pro His 
    1520                 1525                 1530             


Arg Val  Ala Cys Lys Arg Leu  Val Ala Met Asn Met  Pro Leu Asn 
    1535                 1540                 1545             


Ser Asp  Gly Xaa Val Met Phe  Asn Ala Xaa Leu Phe  Ala Leu Val 
    1550                 1555                 1560             


Arg Xaa  Ala Leu Lys Ile Lys  Xaa Glu Gly Asn Leu  Glu Gln Ala 
    1565                 1570                 1575             


Asn Glu  Glu Leu Arg Ala Val  Ile Lys Lys Ile Trp  Lys Lys Xaa 
    1580                 1585                 1590             


Ser Met  Lys Leu Leu Asp Gln  Val Val Pro Pro Ala  Gly Asp Asp 
    1595                 1600                 1605             


Glu Val  Xaa Val Gly Lys Phe  Tyr Ala Xaa Phe Leu  Ile Gln Asp 
    1610                 1615                 1620             


Tyr Phe  Arg Lys Phe Lys Lys  Arg Lys Glu Gln Gly  Leu Val Gly 
    1625                 1630                 1635             


Lys Tyr  Pro Ala Lys Asn Xaa  Xaa Ile Ala Leu Gln  Ala Gly Leu 
    1640                 1645                 1650             


Arg Xaa  Leu His Asp Ile Gly  Pro Glu Ile Arg Arg  Ala Ile Ser 
    1655                 1660                 1665             


Cys Asp  Leu Gln Asp Asp Glu  Pro Glu Glu Xaa Lys  Arg Glu Glu 
    1670                 1675                 1680             


Glu Asp  Asp Val Phe Lys Arg  Asn Gly Ala Leu Leu  Gly Asn His 
    1685                 1690                 1695             


Val Asn  His Val Asn Ser Asp  Arg Arg Asp Ser Leu  Gln Gln Xaa 
    1700                 1705                 1710             


Asn Xaa  Xaa His Arg Pro Leu  His Val Gln Arg Pro  Ser Ile Pro 
    1715                 1720                 1725             


Pro Ala  Ser Asp Xaa Glu Lys  Pro Leu Phe Pro Pro  Ala Gly Asn 
    1730                 1735                 1740             


Ser Val  Cys His Asn His His  Asn His Asn Ser Ile  Gly Lys Gln 
    1745                 1750                 1755             


Val Pro  Xaa Ser Xaa Asn Ala  Asn Leu Asn Asn Ala  Asn Met Ser 
    1760                 1765                 1770             


Lys Ala  Ala His Gly Lys Arg  Pro Ser Ile Gly Asn  Leu Glu His 
    1775                 1780                 1785             


Val Ser  Glu Asn Gly His His  Ser Ser His Lys His  Asp Arg Glu 
    1790                 1795                 1800             


Pro Gln  Arg Arg Ser Ser Val  Lys Arg Xaa Arg Tyr  Tyr Glu Xaa 
    1805                 1810                 1815             


Tyr Ile  Arg Ser Asp Ser Gly  Asp Glu Gln Leu Pro  Xaa Ile Cys 
    1820                 1825                 1830             


Arg Glu  Asp Pro Glu Ile His  Gly Tyr Phe Arg Asp  Pro His Cys 
    1835                 1840                 1845             


Leu Gly  Glu Gln Glu Tyr Phe  Ser Ser Glu Glu Cys  Tyr Glu Asp 
    1850                 1855                 1860             


Asp Ser  Ser Pro Xaa Trp Ser  Arg Gln Asn Tyr Gly  Tyr Tyr Ser 
    1865                 1870                 1875             


Arg Tyr  Pro Gly Arg Asn Ile  Asp Ser Glu Arg Pro  Arg Gly Tyr 
    1880                 1885                 1890             


His His  Pro Gln Gly Phe Leu  Glu Asp Asp Asp Ser  Pro Val Cys 
    1895                 1900                 1905             


Tyr Asp  Ser Arg Arg Ser Pro  Arg Arg Arg Leu Leu  Pro Pro Xaa 
    1910                 1915                 1920             


Pro Ala  Ser His Arg Arg Ser  Ser Phe Asn Phe Glu  Cys Leu Arg 
    1925                 1930                 1935             


Arg Gln  Ser Ser Gln Glu Glu  Val Pro Ser Ser Pro  Ile Phe Pro 
    1940                 1945                 1950             


His Arg  Xaa Ala Leu Pro Leu  His Leu Met Gln Gln  Gln Ile Met 
    1955                 1960                 1965             


Ala Val  Ala Gly Leu Asp Ser  Ser Lys Ala Gln Lys  Tyr Ser Pro 
    1970                 1975                 1980             


Ser His  Ser Xaa Arg Ser Trp  Ala Xaa Pro Pro Ala  Xaa Pro Pro 
    1985                 1990                 1995             


Tyr Arg  Asp Trp Xaa Pro Cys  Tyr Xaa Pro Leu Ile  Gln Val Glu 
    2000                 2005                 2010             


Gln Ser  Glu Ala Leu Asp Gln  Val Asn Gly Ser Leu  Pro Ser Leu 
    2015                 2020                 2025             


His Arg  Ser Ser Trp Tyr Xaa  Asp Glu Pro Asp Ile  Ser Tyr Arg 
    2030                 2035                 2040             


Xaa Phe  Xaa Pro Ala Ser Leu  Xaa Val Pro Ser Ser  Phe Arg Asn 
    2045                 2050                 2055             


Lys Asn  Ser Asp Lys Gln Arg  Ser Ala Asp Ser Leu  Val Glu Ala 
    2060                 2065                 2070             


Val Leu  Ile Ser Glu Gly Leu  Gly Arg Tyr Ala Arg  Asp Pro Lys 
    2075                 2080                 2085             


Phe Val  Ser Ala Xaa Lys His  Glu Ile Ala Asp Ala  Cys Asp Leu 
    2090                 2095                 2100             


Xaa Ile  Asp Glu Met Glu Ser  Ala Ala Ser Xaa Leu  Leu Asn Gly 
    2105                 2110                 2115             


Asn Val  Arg Pro Arg Ala Asn  Gly Asp Val Gly Pro  Leu Ser His 
    2120                 2125                 2130             


Arg Gln  Asp Tyr Glu Leu Gln  Asp Phe Gly Pro Gly  Tyr Ser Asp 
    2135                 2140                 2145             


Glu Glu  Pro Asp Pro Gly Arg  Asp Glu Glu Asp Leu  Ala Asp Glu 
    2150                 2155                 2160             


Met Ile  Cys Ile Xaa Xaa Leu  
    2165                 2170 


<210> 4680
<211> 1647
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1245)..(1245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1316)..(1316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1338)..(1338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1342)..(1342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1391)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1471)..(1471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1507)..(1507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1543)..(1543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1549)..(1549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1556)..(1556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1562)..(1562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1584)..(1584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1602)..(1602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1636)..(1637)
<223> Selenocysteine

<400> 4680
Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15      


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Xaa Arg Leu 
            20                  25                  30          


Pro Leu Ser Gly Glu Gly Pro Xaa Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45              


Xaa Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60                  


Ala Ala Gln Xaa Met Ser Xaa Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80  


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95      


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110         


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125             


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140                 


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Xaa Asn His Asn 
145                 150                 155                 160 


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Xaa Val Glu Xaa 
                165                 170                 175     


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190         


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205             


Leu Phe Ser Val Ile Leu Glu Gln Leu Xaa Lys Glu Xaa Glu Gly Gly 
    210                 215                 220                 


Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
225                 230                 235                 240 


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                245                 250                 255     


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
            260                 265                 270         


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
        275                 280                 285             


Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Xaa Cys Phe Phe Ala 
    290                 295                 300                 


Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
305                 310                 315                 320 


Gly Asn Gly Arg Gln Cys Xaa Ala Asn Gly Xaa Glu Cys Arg Ser Gly 
                325                 330                 335     


Trp Val Gly Pro Asn Gly Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe 
            340                 345                 350         


Ala Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp 
        355                 360                 365             


Val Leu Tyr Trp Val Asn Asp Ala Ile Gly Trp Glu Trp Pro Trp Val 
    370                 375                 380                 


Tyr Phe Val Ser Leu Ile Ile Leu Gly Ser Phe Phe Val Leu Asn Leu 
385                 390                 395                 400 


Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                405                 410                 415     


Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
            420                 425                 430         


Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile 
        435                 440                 445             


Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Xaa 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ser 
465                 470                 475                 480 


Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Cys Gln Ala Ile 
                485                 490                 495     


Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp Asn Arg Phe Asn 
            500                 505                 510         


Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Xaa Phe Tyr Trp Leu 
        515                 520                 525             


Val Ile Val Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ser Ser Glu His 
    530                 535                 540                 


Tyr Asn Gln Pro Asp Trp Leu Xaa Gln Ile Gln Asp Ile Ala Asn Lys 
545                 550                 555                 560 


Val Leu Leu Ala Leu Phe Xaa Cys Glu Met Leu Val Lys Met Tyr Ser 
                565                 570                 575     


Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp Cys 
            580                 585                 590         


Phe Val Val Cys Gly Gly Ile Xaa Glu Xaa Ile Leu Val Glu Leu Glu 
        595                 600                 605             


Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys Val Arg Leu Leu 
    610                 615                 620                 


Arg Ile Phe Lys Val Xaa Arg His Trp Xaa Ser Leu Ser Asn Leu Val 
625                 630                 635                 640 


Ala Ser Leu Leu Asn Ser Met Lys Ser Ile Ala Ser Leu Leu Leu Leu 
                645                 650                 655     


Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe 
            660                 665                 670         


Gly Gly Lys Phe Asn Phe Asp Glu Xaa Gln Xaa Lys Arg Ser Xaa Phe 
        675                 680                 685             


Asp Asn Phe Pro Gln Ala Leu Leu Xaa Val Phe Gln Ile Leu Xaa Gly 
    690                 695                 700                 


Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly 
705                 710                 715                 720 


Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe Ile Ile Leu Phe 
                725                 730                 735     


Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val 
            740                 745                 750         


Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Xaa Ala Gln Lys Glu Glu 
        755                 760                 765             


Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys Glu Ser Leu Glu 
    770                 775                 780                 


Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile Ala Asn Ser Asp 
785                 790                 795                 800 


Asn Lys Val Xaa Ile Asp Asp Tyr Arg Glu Glu Asp Glu Asp Lys Asp 
                805                 810                 815     


Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu Glu Glu Glu Glu 
            820                 825                 830         


Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg Pro Arg Arg Ile 
        835                 840                 845             


Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile Pro Glu Gly Ser 
    850                 855                 860                 


Ala Phe Phe Ile Leu Ser Lys Xaa Asn Pro Ile Arg Val Gly Cys His 
865                 870                 875                 880 


Lys Leu Ile Asn His His Ile Phe Xaa Asn Leu Ile Leu Val Phe Ile 
                885                 890                 895     


Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro Ile Arg Ser His 
            900                 905                 910         


Ser Phe Arg Asn Xaa Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Xaa Ala 
        915                 920                 925             


Ile Phe Xaa Val Glu Ile Leu Leu Lys Met Xaa Xaa Phe Gly Ala Phe 
    930                 935                 940                 


Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn Leu Leu Asp Met 
945                 950                 955                 960 


Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile Gln Ser Ser Ala 
                965                 970                 975     


Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu 
            980                 985                 990         


Arg Ala Ile Asn Arg Ala Lys Gly  Leu Lys His Val Val  Gln Cys Val 
        995                 1000                 1005             


Phe Val  Ala Ile Arg Xaa Ile  Gly Asn Ile Met Ile  Val Xaa Xaa 
    1010                 1015                 1020             


Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly Val Gln  Leu Phe Lys 
    1025                 1030                 1035             


Gly Lys  Phe Tyr Arg Cys Xaa  Asp Glu Ala Lys Ser  Asn Pro Glu 
    1040                 1045                 1050             


Glu Cys  Arg Gly Leu Phe Ile  Leu Tyr Lys Asp Gly  Asp Val Asp 
    1055                 1060                 1065             


Ser Pro  Val Val Arg Glu Arg  Ile Trp Gln Asn Ser  Asp Phe Asn 
    1070                 1075                 1080             


Phe Asp  Asn Val Leu Ser Ala  Met Met Ala Leu Phe  Xaa Val Ser 
    1085                 1090                 1095             


Xaa Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr Lys Ala  Ile Asp Ser 
    1100                 1105                 1110             


Asn Gly  Glu Asn Ile Gly Pro  Ile Tyr Asn His Arg  Val Glu Ile 
    1115                 1120                 1125             


Ser Ile  Phe Phe Ile Ile Tyr  Ile Ile Ile Val Ala  Phe Phe Met 
    1130                 1135                 1140             


Met Asn  Ile Phe Val Gly Phe  Val Ile Val Xaa Phe  Gln Glu Gln 
    1145                 1150                 1155             


Gly Glu  Lys Glu Tyr Lys Asn  Cys Glu Leu Asp Lys  Asn Gln Arg 
    1160                 1165                 1170             


Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Arg Pro Leu  Arg Arg Tyr 
    1175                 1180                 1185             


Ile Pro  Lys Asn Pro Tyr Gln  Tyr Lys Phe Trp Tyr  Val Val Asn 
    1190                 1195                 1200             


Ser Ser  Pro Phe Glu Tyr Met  Met Phe Val Leu Ile  Met Leu Asn 
    1205                 1210                 1215             


Xaa Leu  Cys Leu Ala Met Gln  His Tyr Glu Gln Ser  Lys Met Phe 
    1220                 1225                 1230             


Asn Asp  Ala Met Asp Ile Leu  Asn Met Val Phe Xaa  Gly Val Phe 
    1235                 1240                 1245             


Xaa Val  Glu Met Val Leu Lys  Val Ile Ala Phe Lys  Pro Lys Gly 
    1250                 1255                 1260             


Tyr Phe  Ser Asp Ala Trp Asn  Xaa Phe Asp Ser Leu  Ile Val Ile 
    1265                 1270                 1275             


Gly Ser  Ile Ile Asp Val Ala  Leu Ser Glu Ala Asp  Pro Xaa Glu 
    1280                 1285                 1290             


Ser Glu  Asn Val Pro Val Pro  Xaa Ala Xaa Pro Gly  Asn Ser Glu 
    1295                 1300                 1305             


Glu Ser  Asn Arg Ile Ser Ile  Xaa Phe Phe Arg Leu  Phe Arg Val 
    1310                 1315                 1320             


Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Xaa 
    1325                 1330                 1335             


Leu Leu  Trp Xaa Phe Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val 
    1340                 1345                 1350             


Ala Leu  Leu Ile Ala Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly 
    1355                 1360                 1365             


Met Gln  Met Phe Gly Lys Val  Ala Met Arg Asp Asn  Asn Gln Ile 
    1370                 1375                 1380             


Asn Arg  Asn Asn Asn Phe Gln  Xaa Phe Pro Gln Ala  Val Leu Leu 
    1385                 1390                 1395             


Leu Phe  Arg Cys Ala Xaa Gly  Glu Ala Trp Gln Glu  Ile Met Leu 
    1400                 1405                 1410             


Ala Cys  Leu Pro Gly Lys Leu  Cys Asp Pro Glu Ser  Asp Tyr Asn 
    1415                 1420                 1425             


Pro Gly  Glu Glu Tyr Xaa Cys  Gly Ser Asn Phe Ala  Ile Val Tyr 
    1430                 1435                 1440             


Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu 
    1445                 1450                 1455             


Phe Val  Ala Val Ile Met Asp  Asn Phe Asp Tyr Leu  Xaa Arg Asp 
    1460                 1465                 1470             


Trp Ser  Ile Leu Gly Pro His  His Leu Asp Glu Phe  Lys Arg Ile 
    1475                 1480                 1485             


Trp Ser  Glu Tyr Asp Pro Glu  Ala Lys Gly Arg Ile  Lys His Leu 
    1490                 1495                 1500             


Asp Val  Val Xaa Leu Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe 
    1505                 1510                 1515             


Gly Lys  Leu Cys Pro His Arg  Val Ala Cys Lys Arg  Leu Val Ala 
    1520                 1525                 1530             


Met Asn  Met Pro Leu Asn Ser  Asp Gly Xaa Val Met  Phe Asn Ala 
    1535                 1540                 1545             


Xaa Leu  Phe Ala Leu Val Arg  Xaa Ala Leu Lys Ile  Lys Xaa Glu 
    1550                 1555                 1560             


Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu Arg Ala  Val Ile Lys 
    1565                 1570                 1575             


Lys Ile  Trp Lys Lys Xaa Ser  Met Lys Leu Leu Asp  Gln Val Val 
    1580                 1585                 1590             


Pro Pro  Ala Gly Asp Asp Glu  Val Xaa Val Gly Lys  Phe Tyr Ala 
    1595                 1600                 1605             


Xaa Phe  Leu Ile Gln Asp Tyr  Phe Arg Lys Phe Lys  Lys Arg Lys 
    1610                 1615                 1620             


Glu Gln  Gly Leu Val Gly Lys  Tyr Pro Ala Lys Asn  Xaa Xaa Ile 
    1625                 1630                 1635             


Ala Leu  Gln Met Leu Glu Arg  Met Leu 
    1640                 1645         


<210> 4681
<211> 2137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1245)..(1245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1323)..(1323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1327)..(1327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1419)..(1419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1456)..(1456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1492)..(1492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1528)..(1528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1534)..(1534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1541)..(1541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1569)..(1569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1587)..(1587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1631)..(1631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1655)..(1655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1689)..(1689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1691)..(1692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1709)..(1709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1737)..(1737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1739)..(1739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1798)..(1798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1835)..(1835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1890)..(1890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1923)..(1923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1954)..(1954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1959)..(1959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1963)..(1963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1970)..(1970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1974)..(1974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2002)..(2002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2011)..(2011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2013)..(2013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2018)..(2018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2060)..(2060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2071)..(2071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2081)..(2081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2135)..(2136)
<223> Selenocysteine

<400> 4681
Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15      


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Xaa Arg Leu 
            20                  25                  30          


Pro Leu Ser Gly Glu Gly Pro Xaa Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45              


Xaa Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60                  


Ala Ala Gln Xaa Met Ser Xaa Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80  


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95      


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110         


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125             


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140                 


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Xaa Asn His Asn 
145                 150                 155                 160 


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Xaa Val Glu Xaa 
                165                 170                 175     


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190         


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205             


Leu Phe Ser Val Ile Leu Glu Gln Leu Xaa Lys Glu Xaa Glu Gly Gly 
    210                 215                 220                 


Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
225                 230                 235                 240 


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                245                 250                 255     


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
            260                 265                 270         


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
        275                 280                 285             


Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Xaa Cys Phe Phe Ala 
    290                 295                 300                 


Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
305                 310                 315                 320 


Gly Asn Gly Arg Gln Cys Xaa Ala Asn Gly Xaa Glu Cys Arg Ser Gly 
                325                 330                 335     


Trp Val Gly Pro Asn Gly Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe 
            340                 345                 350         


Ala Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp 
        355                 360                 365             


Val Leu Tyr Trp Met Asn Asp Ala Met Gly Phe Glu Leu Pro Trp Val 
    370                 375                 380                 


Tyr Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu 
385                 390                 395                 400 


Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                405                 410                 415     


Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
            420                 425                 430         


Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile 
        435                 440                 445             


Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Xaa 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ser 
465                 470                 475                 480 


Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Cys Gln Ala Ile 
                485                 490                 495     


Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp Asn Arg Phe Asn 
            500                 505                 510         


Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Xaa Phe Tyr Trp Leu 
        515                 520                 525             


Val Ile Val Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ser Ser Glu His 
    530                 535                 540                 


Tyr Asn Gln Pro Asp Trp Leu Xaa Gln Ile Gln Asp Ile Ala Asn Lys 
545                 550                 555                 560 


Val Leu Leu Ala Leu Phe Xaa Cys Glu Met Leu Val Lys Met Tyr Ser 
                565                 570                 575     


Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp Cys 
            580                 585                 590         


Phe Val Val Cys Gly Gly Ile Xaa Glu Xaa Ile Leu Val Glu Leu Glu 
        595                 600                 605             


Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys Val Arg Leu Leu 
    610                 615                 620                 


Arg Ile Phe Lys Val Xaa Arg His Trp Xaa Ser Leu Ser Asn Leu Val 
625                 630                 635                 640 


Ala Ser Leu Leu Asn Ser Met Lys Ser Ile Ala Ser Leu Leu Leu Leu 
                645                 650                 655     


Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe 
            660                 665                 670         


Gly Gly Lys Phe Asn Phe Asp Glu Xaa Gln Xaa Lys Arg Ser Xaa Phe 
        675                 680                 685             


Asp Asn Phe Pro Gln Ala Leu Leu Xaa Val Phe Gln Ile Leu Xaa Gly 
    690                 695                 700                 


Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly 
705                 710                 715                 720 


Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe Ile Ile Leu Phe 
                725                 730                 735     


Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val 
            740                 745                 750         


Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Xaa Ala Gln Lys Glu Glu 
        755                 760                 765             


Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys Glu Ser Leu Glu 
    770                 775                 780                 


Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile Ala Asn Ser Asp 
785                 790                 795                 800 


Asn Lys Val Xaa Ile Asp Asp Tyr Arg Glu Glu Asp Glu Asp Lys Asp 
                805                 810                 815     


Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu Glu Glu Glu Glu 
            820                 825                 830         


Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg Pro Arg Arg Ile 
        835                 840                 845             


Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile Pro Glu Gly Ser 
    850                 855                 860                 


Ala Phe Phe Ile Leu Ser Lys Xaa Asn Pro Ile Arg Val Gly Cys His 
865                 870                 875                 880 


Lys Leu Ile Asn His His Ile Phe Xaa Asn Leu Ile Leu Val Phe Ile 
                885                 890                 895     


Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro Ile Arg Ser His 
            900                 905                 910         


Ser Phe Arg Asn Xaa Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Xaa Ala 
        915                 920                 925             


Ile Phe Xaa Val Glu Ile Leu Leu Lys Met Xaa Xaa Phe Gly Ala Phe 
    930                 935                 940                 


Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn Leu Leu Asp Met 
945                 950                 955                 960 


Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile Gln Ser Ser Ala 
                965                 970                 975     


Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu 
            980                 985                 990         


Arg Ala Ile Asn Arg Ala Lys Gly  Leu Lys His Val Val  Gln Cys Val 
        995                 1000                 1005             


Phe Val  Ala Ile Arg Xaa Ile  Gly Asn Ile Met Ile  Val Xaa Xaa 
    1010                 1015                 1020             


Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly Val Gln  Leu Phe Lys 
    1025                 1030                 1035             


Gly Lys  Phe Tyr Arg Cys Xaa  Asp Glu Ala Lys Ser  Asn Pro Glu 
    1040                 1045                 1050             


Glu Cys  Arg Gly Leu Phe Ile  Leu Tyr Lys Asp Gly  Asp Val Asp 
    1055                 1060                 1065             


Ser Pro  Val Val Arg Glu Arg  Ile Trp Gln Asn Ser  Asp Phe Asn 
    1070                 1075                 1080             


Phe Asp  Asn Val Leu Ser Ala  Met Met Ala Leu Phe  Xaa Val Ser 
    1085                 1090                 1095             


Xaa Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr Lys Ala  Ile Asp Ser 
    1100                 1105                 1110             


Asn Gly  Glu Asn Ile Gly Pro  Ile Tyr Asn His Arg  Val Glu Ile 
    1115                 1120                 1125             


Ser Ile  Phe Phe Ile Ile Tyr  Ile Ile Ile Val Ala  Phe Phe Met 
    1130                 1135                 1140             


Met Asn  Ile Phe Val Gly Phe  Val Ile Val Xaa Phe  Gln Glu Gln 
    1145                 1150                 1155             


Gly Glu  Lys Glu Tyr Lys Asn  Cys Glu Leu Asp Lys  Asn Gln Arg 
    1160                 1165                 1170             


Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Arg Pro Leu  Arg Arg Tyr 
    1175                 1180                 1185             


Ile Pro  Lys Asn Pro Tyr Gln  Tyr Lys Phe Trp Tyr  Val Val Asn 
    1190                 1195                 1200             


Ser Ser  Pro Phe Glu Tyr Met  Met Phe Val Leu Ile  Met Leu Asn 
    1205                 1210                 1215             


Xaa Leu  Cys Leu Ala Met Gln  His Tyr Glu Gln Ser  Lys Met Phe 
    1220                 1225                 1230             


Asn Asp  Ala Met Asp Ile Leu  Asn Met Val Phe Xaa  Gly Val Phe 
    1235                 1240                 1245             


Xaa Val  Glu Met Val Leu Lys  Val Ile Ala Phe Lys  Pro Lys Gly 
    1250                 1255                 1260             


Tyr Phe  Ser Asp Ala Trp Asn  Xaa Phe Asp Ser Leu  Ile Val Ile 
    1265                 1270                 1275             


Gly Ser  Ile Ile Asp Val Ala  Leu Ser Glu Ala Asp  Asn Ser Glu 
    1280                 1285                 1290             


Glu Ser  Asn Arg Ile Ser Ile  Xaa Phe Phe Arg Leu  Phe Arg Val 
    1295                 1300                 1305             


Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Xaa 
    1310                 1315                 1320             


Leu Leu  Trp Xaa Phe Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val 
    1325                 1330                 1335             


Ala Leu  Leu Ile Ala Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly 
    1340                 1345                 1350             


Met Gln  Met Phe Gly Lys Val  Ala Met Arg Asp Asn  Asn Gln Ile 
    1355                 1360                 1365             


Asn Arg  Asn Asn Asn Phe Gln  Xaa Phe Pro Gln Ala  Val Leu Leu 
    1370                 1375                 1380             


Leu Phe  Arg Cys Ala Xaa Gly  Glu Ala Trp Gln Glu  Ile Met Leu 
    1385                 1390                 1395             


Ala Cys  Leu Pro Gly Lys Leu  Cys Asp Pro Glu Ser  Asp Tyr Asn 
    1400                 1405                 1410             


Pro Gly  Glu Glu Tyr Xaa Cys  Gly Ser Asn Phe Ala  Ile Val Tyr 
    1415                 1420                 1425             


Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu 
    1430                 1435                 1440             


Phe Val  Ala Val Ile Met Asp  Asn Phe Asp Tyr Leu  Xaa Arg Asp 
    1445                 1450                 1455             


Trp Ser  Ile Leu Gly Pro His  His Leu Asp Glu Phe  Lys Arg Ile 
    1460                 1465                 1470             


Trp Ser  Glu Tyr Asp Pro Glu  Ala Lys Gly Arg Ile  Lys His Leu 
    1475                 1480                 1485             


Asp Val  Val Xaa Leu Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe 
    1490                 1495                 1500             


Gly Lys  Leu Cys Pro His Arg  Val Ala Cys Lys Arg  Leu Val Ala 
    1505                 1510                 1515             


Met Asn  Met Pro Leu Asn Ser  Asp Gly Xaa Val Met  Phe Asn Ala 
    1520                 1525                 1530             


Xaa Leu  Phe Ala Leu Val Arg  Xaa Ala Leu Lys Ile  Lys Xaa Glu 
    1535                 1540                 1545             


Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu Arg Ala  Val Ile Lys 
    1550                 1555                 1560             


Lys Ile  Trp Lys Lys Xaa Ser  Met Lys Leu Leu Asp  Gln Val Val 
    1565                 1570                 1575             


Pro Pro  Ala Gly Asp Asp Glu  Val Xaa Val Gly Lys  Phe Tyr Ala 
    1580                 1585                 1590             


Xaa Phe  Leu Ile Gln Asp Tyr  Phe Arg Lys Phe Lys  Lys Arg Lys 
    1595                 1600                 1605             


Glu Gln  Gly Leu Val Gly Lys  Tyr Pro Ala Lys Asn  Xaa Xaa Ile 
    1610                 1615                 1620             


Ala Leu  Gln Ala Gly Leu Arg  Xaa Leu His Asp Ile  Gly Pro Glu 
    1625                 1630                 1635             


Ile Arg  Arg Ala Ile Ser Cys  Asp Leu Gln Asp Asp  Glu Pro Glu 
    1640                 1645                 1650             


Glu Xaa  Lys Arg Glu Glu Glu  Asp Asp Val Phe Lys  Arg Asn Gly 
    1655                 1660                 1665             


Ala Leu  Leu Gly Asn His Val  Asn His Val Asn Ser  Asp Arg Arg 
    1670                 1675                 1680             


Asp Ser  Leu Gln Gln Xaa Asn  Xaa Xaa His Arg Pro  Leu His Val 
    1685                 1690                 1695             


Gln Arg  Pro Ser Ile Pro Pro  Ala Ser Asp Xaa Glu  Lys Pro Leu 
    1700                 1705                 1710             


Phe Pro  Pro Ala Gly Asn Ser  Val Cys His Asn His  His Asn His 
    1715                 1720                 1725             


Asn Ser  Ile Gly Lys Gln Val  Pro Xaa Ser Xaa Asn  Ala Asn Leu 
    1730                 1735                 1740             


Asn Asn  Ala Asn Met Ser Lys  Ala Ala His Gly Lys  Arg Pro Ser 
    1745                 1750                 1755             


Ile Gly  Asn Leu Glu His Val  Ser Glu Asn Gly His  His Ser Ser 
    1760                 1765                 1770             


His Lys  His Asp Arg Glu Pro  Gln Arg Arg Ser Ser  Val Lys Arg 
    1775                 1780                 1785             


Ser Asp  Ser Gly Asp Glu Gln  Leu Pro Xaa Ile Cys  Arg Glu Asp 
    1790                 1795                 1800             


Pro Glu  Ile His Gly Tyr Phe  Arg Asp Pro His Cys  Leu Gly Glu 
    1805                 1810                 1815             


Gln Glu  Tyr Phe Ser Ser Glu  Glu Cys Tyr Glu Asp  Asp Ser Ser 
    1820                 1825                 1830             


Pro Xaa  Trp Ser Arg Gln Asn  Tyr Gly Tyr Tyr Ser  Arg Tyr Pro 
    1835                 1840                 1845             


Gly Arg  Asn Ile Asp Ser Glu  Arg Pro Arg Gly Tyr  His His Pro 
    1850                 1855                 1860             


Gln Gly  Phe Leu Glu Asp Asp  Asp Ser Pro Val Cys  Tyr Asp Ser 
    1865                 1870                 1875             


Arg Arg  Ser Pro Arg Arg Arg  Leu Leu Pro Pro Xaa  Pro Ala Ser 
    1880                 1885                 1890             


His Arg  Arg Ser Ser Phe Asn  Phe Glu Cys Leu Arg  Arg Gln Ser 
    1895                 1900                 1905             


Ser Gln  Glu Glu Val Pro Ser  Ser Pro Ile Phe Pro  His Arg Xaa 
    1910                 1915                 1920             


Ala Leu  Pro Leu His Leu Met  Gln Gln Gln Ile Met  Ala Val Ala 
    1925                 1930                 1935             


Gly Leu  Asp Ser Ser Lys Ala  Gln Lys Tyr Ser Pro  Ser His Ser 
    1940                 1945                 1950             


Xaa Arg  Ser Trp Ala Xaa Pro  Pro Ala Xaa Pro Pro  Tyr Arg Asp 
    1955                 1960                 1965             


Trp Xaa  Pro Cys Tyr Xaa Pro  Leu Ile Gln Val Glu  Gln Ser Glu 
    1970                 1975                 1980             


Ala Leu  Asp Gln Val Asn Gly  Ser Leu Pro Ser Leu  His Arg Ser 
    1985                 1990                 1995             


Ser Trp  Tyr Xaa Asp Glu Pro  Asp Ile Ser Tyr Arg  Xaa Phe Xaa 
    2000                 2005                 2010             


Pro Ala  Ser Leu Xaa Val Pro  Ser Ser Phe Arg Asn  Lys Asn Ser 
    2015                 2020                 2025             


Asp Lys  Gln Arg Ser Ala Asp  Ser Leu Val Glu Ala  Val Leu Ile 
    2030                 2035                 2040             


Ser Glu  Gly Leu Gly Arg Tyr  Ala Arg Asp Pro Lys  Phe Val Ser 
    2045                 2050                 2055             


Ala Xaa  Lys His Glu Ile Ala  Asp Ala Cys Asp Leu  Xaa Ile Asp 
    2060                 2065                 2070             


Glu Met  Glu Ser Ala Ala Ser  Xaa Leu Leu Asn Gly  Asn Val Arg 
    2075                 2080                 2085             


Pro Arg  Ala Asn Gly Asp Val  Gly Pro Leu Ser His  Arg Gln Asp 
    2090                 2095                 2100             


Tyr Glu  Leu Gln Asp Phe Gly  Pro Gly Tyr Ser Asp  Glu Glu Pro 
    2105                 2110                 2115             


Asp Pro  Gly Arg Asp Glu Glu  Asp Leu Ala Asp Glu  Met Ile Cys 
    2120                 2125                 2130             


Ile Xaa  Xaa Leu 
    2135         


<210> 4682
<211> 2146
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1245)..(1245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1323)..(1323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1327)..(1327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1419)..(1419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1456)..(1456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1492)..(1492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1528)..(1528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1534)..(1534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1541)..(1541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1569)..(1569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1587)..(1587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1631)..(1631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1655)..(1655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1689)..(1689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1691)..(1692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1709)..(1709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1737)..(1737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1739)..(1739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1789)..(1789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1794)..(1794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1807)..(1807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1844)..(1844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1899)..(1899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1932)..(1932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1963)..(1963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1968)..(1968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1972)..(1972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1979)..(1979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1983)..(1983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2011)..(2011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2020)..(2020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2022)..(2022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2027)..(2027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2069)..(2069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2080)..(2080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2090)..(2090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2144)..(2145)
<223> Selenocysteine

<400> 4682
Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15      


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Xaa Arg Leu 
            20                  25                  30          


Pro Leu Ser Gly Glu Gly Pro Xaa Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45              


Xaa Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60                  


Ala Ala Gln Xaa Met Ser Xaa Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80  


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95      


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110         


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125             


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140                 


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Xaa Asn His Asn 
145                 150                 155                 160 


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Xaa Val Glu Xaa 
                165                 170                 175     


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190         


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205             


Leu Phe Ser Val Ile Leu Glu Gln Leu Xaa Lys Glu Xaa Glu Gly Gly 
    210                 215                 220                 


Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
225                 230                 235                 240 


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                245                 250                 255     


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
            260                 265                 270         


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
        275                 280                 285             


Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Xaa Cys Phe Phe Ala 
    290                 295                 300                 


Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
305                 310                 315                 320 


Gly Asn Gly Arg Gln Cys Xaa Ala Asn Gly Xaa Glu Cys Arg Ser Gly 
                325                 330                 335     


Trp Val Gly Pro Asn Gly Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe 
            340                 345                 350         


Ala Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp 
        355                 360                 365             


Val Leu Tyr Trp Val Asn Asp Ala Ile Gly Trp Glu Trp Pro Trp Val 
    370                 375                 380                 


Tyr Phe Val Ser Leu Ile Ile Leu Gly Ser Phe Phe Val Leu Asn Leu 
385                 390                 395                 400 


Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                405                 410                 415     


Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
            420                 425                 430         


Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile 
        435                 440                 445             


Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Xaa 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ser 
465                 470                 475                 480 


Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Cys Gln Ala Ile 
                485                 490                 495     


Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp Asn Arg Phe Asn 
            500                 505                 510         


Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Xaa Phe Tyr Trp Leu 
        515                 520                 525             


Val Ile Val Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ser Ser Glu His 
    530                 535                 540                 


Tyr Asn Gln Pro Asp Trp Leu Xaa Gln Ile Gln Asp Ile Ala Asn Lys 
545                 550                 555                 560 


Val Leu Leu Ala Leu Phe Xaa Cys Glu Met Leu Val Lys Met Tyr Ser 
                565                 570                 575     


Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp Cys 
            580                 585                 590         


Phe Val Val Cys Gly Gly Ile Xaa Glu Xaa Ile Leu Val Glu Leu Glu 
        595                 600                 605             


Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys Val Arg Leu Leu 
    610                 615                 620                 


Arg Ile Phe Lys Val Xaa Arg His Trp Xaa Ser Leu Ser Asn Leu Val 
625                 630                 635                 640 


Ala Ser Leu Leu Asn Ser Met Lys Ser Ile Ala Ser Leu Leu Leu Leu 
                645                 650                 655     


Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe 
            660                 665                 670         


Gly Gly Lys Phe Asn Phe Asp Glu Xaa Gln Xaa Lys Arg Ser Xaa Phe 
        675                 680                 685             


Asp Asn Phe Pro Gln Ala Leu Leu Xaa Val Phe Gln Ile Leu Xaa Gly 
    690                 695                 700                 


Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly 
705                 710                 715                 720 


Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe Ile Ile Leu Phe 
                725                 730                 735     


Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val 
            740                 745                 750         


Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Xaa Ala Gln Lys Glu Glu 
        755                 760                 765             


Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys Glu Ser Leu Glu 
    770                 775                 780                 


Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile Ala Asn Ser Asp 
785                 790                 795                 800 


Asn Lys Val Xaa Ile Asp Asp Tyr Arg Glu Glu Asp Glu Asp Lys Asp 
                805                 810                 815     


Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu Glu Glu Glu Glu 
            820                 825                 830         


Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg Pro Arg Arg Ile 
        835                 840                 845             


Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile Pro Glu Gly Ser 
    850                 855                 860                 


Ala Phe Phe Ile Leu Ser Lys Xaa Asn Pro Ile Arg Val Gly Cys His 
865                 870                 875                 880 


Lys Leu Ile Asn His His Ile Phe Xaa Asn Leu Ile Leu Val Phe Ile 
                885                 890                 895     


Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro Ile Arg Ser His 
            900                 905                 910         


Ser Phe Arg Asn Xaa Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Xaa Ala 
        915                 920                 925             


Ile Phe Xaa Val Glu Ile Leu Leu Lys Met Xaa Xaa Phe Gly Ala Phe 
    930                 935                 940                 


Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn Leu Leu Asp Met 
945                 950                 955                 960 


Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile Gln Ser Ser Ala 
                965                 970                 975     


Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu 
            980                 985                 990         


Arg Ala Ile Asn Arg Ala Lys Gly  Leu Lys His Val Val  Gln Cys Val 
        995                 1000                 1005             


Phe Val  Ala Ile Arg Xaa Ile  Gly Asn Ile Met Ile  Val Xaa Xaa 
    1010                 1015                 1020             


Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly Val Gln  Leu Phe Lys 
    1025                 1030                 1035             


Gly Lys  Phe Tyr Arg Cys Xaa  Asp Glu Ala Lys Ser  Asn Pro Glu 
    1040                 1045                 1050             


Glu Cys  Arg Gly Leu Phe Ile  Leu Tyr Lys Asp Gly  Asp Val Asp 
    1055                 1060                 1065             


Ser Pro  Val Val Arg Glu Arg  Ile Trp Gln Asn Ser  Asp Phe Asn 
    1070                 1075                 1080             


Phe Asp  Asn Val Leu Ser Ala  Met Met Ala Leu Phe  Xaa Val Ser 
    1085                 1090                 1095             


Xaa Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr Lys Ala  Ile Asp Ser 
    1100                 1105                 1110             


Asn Gly  Glu Asn Ile Gly Pro  Ile Tyr Asn His Arg  Val Glu Ile 
    1115                 1120                 1125             


Ser Ile  Phe Phe Ile Ile Tyr  Ile Ile Ile Val Ala  Phe Phe Met 
    1130                 1135                 1140             


Met Asn  Ile Phe Val Gly Phe  Val Ile Val Xaa Phe  Gln Glu Gln 
    1145                 1150                 1155             


Gly Glu  Lys Glu Tyr Lys Asn  Cys Glu Leu Asp Lys  Asn Gln Arg 
    1160                 1165                 1170             


Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Arg Pro Leu  Arg Arg Tyr 
    1175                 1180                 1185             


Ile Pro  Lys Asn Pro Tyr Gln  Tyr Lys Phe Trp Tyr  Val Val Asn 
    1190                 1195                 1200             


Ser Ser  Pro Phe Glu Tyr Met  Met Phe Val Leu Ile  Met Leu Asn 
    1205                 1210                 1215             


Xaa Leu  Cys Leu Ala Met Gln  His Tyr Glu Gln Ser  Lys Met Phe 
    1220                 1225                 1230             


Asn Asp  Ala Met Asp Ile Leu  Asn Met Val Phe Xaa  Gly Val Phe 
    1235                 1240                 1245             


Xaa Val  Glu Met Val Leu Lys  Val Ile Ala Phe Lys  Pro Lys Gly 
    1250                 1255                 1260             


Tyr Phe  Ser Asp Ala Trp Asn  Xaa Phe Asp Ser Leu  Ile Val Ile 
    1265                 1270                 1275             


Gly Ser  Ile Ile Asp Val Ala  Leu Ser Glu Ala Asp  Asn Ser Glu 
    1280                 1285                 1290             


Glu Ser  Asn Arg Ile Ser Ile  Xaa Phe Phe Arg Leu  Phe Arg Val 
    1295                 1300                 1305             


Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Xaa 
    1310                 1315                 1320             


Leu Leu  Trp Xaa Phe Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val 
    1325                 1330                 1335             


Ala Leu  Leu Ile Ala Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly 
    1340                 1345                 1350             


Met Gln  Met Phe Gly Lys Val  Ala Met Arg Asp Asn  Asn Gln Ile 
    1355                 1360                 1365             


Asn Arg  Asn Asn Asn Phe Gln  Xaa Phe Pro Gln Ala  Val Leu Leu 
    1370                 1375                 1380             


Leu Phe  Arg Cys Ala Xaa Gly  Glu Ala Trp Gln Glu  Ile Met Leu 
    1385                 1390                 1395             


Ala Cys  Leu Pro Gly Lys Leu  Cys Asp Pro Glu Ser  Asp Tyr Asn 
    1400                 1405                 1410             


Pro Gly  Glu Glu Tyr Xaa Cys  Gly Ser Asn Phe Ala  Ile Val Tyr 
    1415                 1420                 1425             


Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu 
    1430                 1435                 1440             


Phe Val  Ala Val Ile Met Asp  Asn Phe Asp Tyr Leu  Xaa Arg Asp 
    1445                 1450                 1455             


Trp Ser  Ile Leu Gly Pro His  His Leu Asp Glu Phe  Lys Arg Ile 
    1460                 1465                 1470             


Trp Ser  Glu Tyr Asp Pro Glu  Ala Lys Gly Arg Ile  Lys His Leu 
    1475                 1480                 1485             


Asp Val  Val Xaa Leu Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe 
    1490                 1495                 1500             


Gly Lys  Leu Cys Pro His Arg  Val Ala Cys Lys Arg  Leu Val Ala 
    1505                 1510                 1515             


Met Asn  Met Pro Leu Asn Ser  Asp Gly Xaa Val Met  Phe Asn Ala 
    1520                 1525                 1530             


Xaa Leu  Phe Ala Leu Val Arg  Xaa Ala Leu Lys Ile  Lys Xaa Glu 
    1535                 1540                 1545             


Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu Arg Ala  Val Ile Lys 
    1550                 1555                 1560             


Lys Ile  Trp Lys Lys Xaa Ser  Met Lys Leu Leu Asp  Gln Val Val 
    1565                 1570                 1575             


Pro Pro  Ala Gly Asp Asp Glu  Val Xaa Val Gly Lys  Phe Tyr Ala 
    1580                 1585                 1590             


Xaa Phe  Leu Ile Gln Asp Tyr  Phe Arg Lys Phe Lys  Lys Arg Lys 
    1595                 1600                 1605             


Glu Gln  Gly Leu Val Gly Lys  Tyr Pro Ala Lys Asn  Xaa Xaa Ile 
    1610                 1615                 1620             


Ala Leu  Gln Ala Gly Leu Arg  Xaa Leu His Asp Ile  Gly Pro Glu 
    1625                 1630                 1635             


Ile Arg  Arg Ala Ile Ser Cys  Asp Leu Gln Asp Asp  Glu Pro Glu 
    1640                 1645                 1650             


Glu Xaa  Lys Arg Glu Glu Glu  Asp Asp Val Phe Lys  Arg Asn Gly 
    1655                 1660                 1665             


Ala Leu  Leu Gly Asn His Val  Asn His Val Asn Ser  Asp Arg Arg 
    1670                 1675                 1680             


Asp Ser  Leu Gln Gln Xaa Asn  Xaa Xaa His Arg Pro  Leu His Val 
    1685                 1690                 1695             


Gln Arg  Pro Ser Ile Pro Pro  Ala Ser Asp Xaa Glu  Lys Pro Leu 
    1700                 1705                 1710             


Phe Pro  Pro Ala Gly Asn Ser  Val Cys His Asn His  His Asn His 
    1715                 1720                 1725             


Asn Ser  Ile Gly Lys Gln Val  Pro Xaa Ser Xaa Asn  Ala Asn Leu 
    1730                 1735                 1740             


Asn Asn  Ala Asn Met Ser Lys  Ala Ala His Gly Lys  Arg Pro Ser 
    1745                 1750                 1755             


Ile Gly  Asn Leu Glu His Val  Ser Glu Asn Gly His  His Ser Ser 
    1760                 1765                 1770             


His Lys  His Asp Arg Glu Pro  Gln Arg Arg Ser Ser  Val Lys Arg 
    1775                 1780                 1785             


Xaa Arg  Tyr Tyr Glu Xaa Tyr  Ile Arg Ser Asp Ser  Gly Asp Glu 
    1790                 1795                 1800             


Gln Leu  Pro Xaa Ile Cys Arg  Glu Asp Pro Glu Ile  His Gly Tyr 
    1805                 1810                 1815             


Phe Arg  Asp Pro His Cys Leu  Gly Glu Gln Glu Tyr  Phe Ser Ser 
    1820                 1825                 1830             


Glu Glu  Cys Tyr Glu Asp Asp  Ser Ser Pro Xaa Trp  Ser Arg Gln 
    1835                 1840                 1845             


Asn Tyr  Gly Tyr Tyr Ser Arg  Tyr Pro Gly Arg Asn  Ile Asp Ser 
    1850                 1855                 1860             


Glu Arg  Pro Arg Gly Tyr His  His Pro Gln Gly Phe  Leu Glu Asp 
    1865                 1870                 1875             


Asp Asp  Ser Pro Val Cys Tyr  Asp Ser Arg Arg Ser  Pro Arg Arg 
    1880                 1885                 1890             


Arg Leu  Leu Pro Pro Xaa Pro  Ala Ser His Arg Arg  Ser Ser Phe 
    1895                 1900                 1905             


Asn Phe  Glu Cys Leu Arg Arg  Gln Ser Ser Gln Glu  Glu Val Pro 
    1910                 1915                 1920             


Ser Ser  Pro Ile Phe Pro His  Arg Xaa Ala Leu Pro  Leu His Leu 
    1925                 1930                 1935             


Met Gln  Gln Gln Ile Met Ala  Val Ala Gly Leu Asp  Ser Ser Lys 
    1940                 1945                 1950             


Ala Gln  Lys Tyr Ser Pro Ser  His Ser Xaa Arg Ser  Trp Ala Xaa 
    1955                 1960                 1965             


Pro Pro  Ala Xaa Pro Pro Tyr  Arg Asp Trp Xaa Pro  Cys Tyr Xaa 
    1970                 1975                 1980             


Pro Leu  Ile Gln Val Glu Gln  Ser Glu Ala Leu Asp  Gln Val Asn 
    1985                 1990                 1995             


Gly Ser  Leu Pro Ser Leu His  Arg Ser Ser Trp Tyr  Xaa Asp Glu 
    2000                 2005                 2010             


Pro Asp  Ile Ser Tyr Arg Xaa  Phe Xaa Pro Ala Ser  Leu Xaa Val 
    2015                 2020                 2025             


Pro Ser  Ser Phe Arg Asn Lys  Asn Ser Asp Lys Gln  Arg Ser Ala 
    2030                 2035                 2040             


Asp Ser  Leu Val Glu Ala Val  Leu Ile Ser Glu Gly  Leu Gly Arg 
    2045                 2050                 2055             


Tyr Ala  Arg Asp Pro Lys Phe  Val Ser Ala Xaa Lys  His Glu Ile 
    2060                 2065                 2070             


Ala Asp  Ala Cys Asp Leu Xaa  Ile Asp Glu Met Glu  Ser Ala Ala 
    2075                 2080                 2085             


Ser Xaa  Leu Leu Asn Gly Asn  Val Arg Pro Arg Ala  Asn Gly Asp 
    2090                 2095                 2100             


Val Gly  Pro Leu Ser His Arg  Gln Asp Tyr Glu Leu  Gln Asp Phe 
    2105                 2110                 2115             


Gly Pro  Gly Tyr Ser Asp Glu  Glu Pro Asp Pro Gly  Arg Asp Glu 
    2120                 2125                 2130             


Glu Asp  Leu Ala Asp Glu Met  Ile Cys Ile Xaa Xaa  Leu 
    2135                 2140                 2145     


<210> 4683
<211> 2161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1245)..(1245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1316)..(1316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1338)..(1338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1342)..(1342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1391)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1471)..(1471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1507)..(1507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1543)..(1543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1549)..(1549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1556)..(1556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1562)..(1562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1584)..(1584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1602)..(1602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1636)..(1637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1670)..(1670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1704)..(1704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1706)..(1707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1724)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1752)..(1752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1804)..(1804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1809)..(1809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1822)..(1822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1859)..(1859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1914)..(1914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1947)..(1947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1978)..(1978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1983)..(1983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1987)..(1987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1994)..(1994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1998)..(1998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2026)..(2026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2035)..(2035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2037)..(2037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2042)..(2042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2084)..(2084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2095)..(2095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2105)..(2105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2159)..(2160)
<223> Selenocysteine

<400> 4683
Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15      


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Xaa Arg Leu 
            20                  25                  30          


Pro Leu Ser Gly Glu Gly Pro Xaa Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45              


Xaa Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60                  


Ala Ala Gln Xaa Met Ser Xaa Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80  


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95      


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110         


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125             


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140                 


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Xaa Asn His Asn 
145                 150                 155                 160 


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Xaa Val Glu Xaa 
                165                 170                 175     


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190         


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205             


Leu Phe Ser Val Ile Leu Glu Gln Leu Xaa Lys Glu Xaa Glu Gly Gly 
    210                 215                 220                 


Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
225                 230                 235                 240 


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                245                 250                 255     


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
            260                 265                 270         


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
        275                 280                 285             


Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Xaa Cys Phe Phe Ala 
    290                 295                 300                 


Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
305                 310                 315                 320 


Gly Asn Gly Arg Gln Cys Xaa Ala Asn Gly Xaa Glu Cys Arg Ser Gly 
                325                 330                 335     


Trp Val Gly Pro Asn Gly Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe 
            340                 345                 350         


Ala Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp 
        355                 360                 365             


Val Leu Tyr Trp Met Asn Asp Ala Met Gly Phe Glu Leu Pro Trp Val 
    370                 375                 380                 


Tyr Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu 
385                 390                 395                 400 


Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                405                 410                 415     


Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
            420                 425                 430         


Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile 
        435                 440                 445             


Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Xaa 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ser 
465                 470                 475                 480 


Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Cys Gln Ala Ile 
                485                 490                 495     


Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp Asn Arg Phe Asn 
            500                 505                 510         


Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Xaa Phe Tyr Trp Leu 
        515                 520                 525             


Val Ile Val Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ser Ser Glu His 
    530                 535                 540                 


Tyr Asn Gln Pro Asp Trp Leu Xaa Gln Ile Gln Asp Ile Ala Asn Lys 
545                 550                 555                 560 


Val Leu Leu Ala Leu Phe Xaa Cys Glu Met Leu Val Lys Met Tyr Ser 
                565                 570                 575     


Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp Cys 
            580                 585                 590         


Phe Val Val Cys Gly Gly Ile Xaa Glu Xaa Ile Leu Val Glu Leu Glu 
        595                 600                 605             


Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys Val Arg Leu Leu 
    610                 615                 620                 


Arg Ile Phe Lys Val Xaa Arg His Trp Xaa Ser Leu Ser Asn Leu Val 
625                 630                 635                 640 


Ala Ser Leu Leu Asn Ser Met Lys Ser Ile Ala Ser Leu Leu Leu Leu 
                645                 650                 655     


Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe 
            660                 665                 670         


Gly Gly Lys Phe Asn Phe Asp Glu Xaa Gln Xaa Lys Arg Ser Xaa Phe 
        675                 680                 685             


Asp Asn Phe Pro Gln Ala Leu Leu Xaa Val Phe Gln Ile Leu Xaa Gly 
    690                 695                 700                 


Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly 
705                 710                 715                 720 


Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe Ile Ile Leu Phe 
                725                 730                 735     


Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val 
            740                 745                 750         


Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Xaa Ala Gln Lys Glu Glu 
        755                 760                 765             


Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys Glu Ser Leu Glu 
    770                 775                 780                 


Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile Ala Asn Ser Asp 
785                 790                 795                 800 


Asn Lys Val Xaa Ile Asp Asp Tyr Arg Glu Glu Asp Glu Asp Lys Asp 
                805                 810                 815     


Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu Glu Glu Glu Glu 
            820                 825                 830         


Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg Pro Arg Arg Ile 
        835                 840                 845             


Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile Pro Glu Gly Ser 
    850                 855                 860                 


Ala Phe Phe Ile Leu Ser Lys Xaa Asn Pro Ile Arg Val Gly Cys His 
865                 870                 875                 880 


Lys Leu Ile Asn His His Ile Phe Xaa Asn Leu Ile Leu Val Phe Ile 
                885                 890                 895     


Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro Ile Arg Ser His 
            900                 905                 910         


Ser Phe Arg Asn Xaa Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Xaa Ala 
        915                 920                 925             


Ile Phe Xaa Val Glu Ile Leu Leu Lys Met Xaa Xaa Phe Gly Ala Phe 
    930                 935                 940                 


Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn Leu Leu Asp Met 
945                 950                 955                 960 


Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile Gln Ser Ser Ala 
                965                 970                 975     


Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu 
            980                 985                 990         


Arg Ala Ile Asn Arg Ala Lys Gly  Leu Lys His Val Val  Gln Cys Val 
        995                 1000                 1005             


Phe Val  Ala Ile Arg Xaa Ile  Gly Asn Ile Met Ile  Val Xaa Xaa 
    1010                 1015                 1020             


Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly Val Gln  Leu Phe Lys 
    1025                 1030                 1035             


Gly Lys  Phe Tyr Arg Cys Xaa  Asp Glu Ala Lys Ser  Asn Pro Glu 
    1040                 1045                 1050             


Glu Cys  Arg Gly Leu Phe Ile  Leu Tyr Lys Asp Gly  Asp Val Asp 
    1055                 1060                 1065             


Ser Pro  Val Val Arg Glu Arg  Ile Trp Gln Asn Ser  Asp Phe Asn 
    1070                 1075                 1080             


Phe Asp  Asn Val Leu Ser Ala  Met Met Ala Leu Phe  Xaa Val Ser 
    1085                 1090                 1095             


Xaa Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr Lys Ala  Ile Asp Ser 
    1100                 1105                 1110             


Asn Gly  Glu Asn Ile Gly Pro  Ile Tyr Asn His Arg  Val Glu Ile 
    1115                 1120                 1125             


Ser Ile  Phe Phe Ile Ile Tyr  Ile Ile Ile Val Ala  Phe Phe Met 
    1130                 1135                 1140             


Met Asn  Ile Phe Val Gly Phe  Val Ile Val Xaa Phe  Gln Glu Gln 
    1145                 1150                 1155             


Gly Glu  Lys Glu Tyr Lys Asn  Cys Glu Leu Asp Lys  Asn Gln Arg 
    1160                 1165                 1170             


Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Arg Pro Leu  Arg Arg Tyr 
    1175                 1180                 1185             


Ile Pro  Lys Asn Pro Tyr Gln  Tyr Lys Phe Trp Tyr  Val Val Asn 
    1190                 1195                 1200             


Ser Ser  Pro Phe Glu Tyr Met  Met Phe Val Leu Ile  Met Leu Asn 
    1205                 1210                 1215             


Xaa Leu  Cys Leu Ala Met Gln  His Tyr Glu Gln Ser  Lys Met Phe 
    1220                 1225                 1230             


Asn Asp  Ala Met Asp Ile Leu  Asn Met Val Phe Xaa  Gly Val Phe 
    1235                 1240                 1245             


Xaa Val  Glu Met Val Leu Lys  Val Ile Ala Phe Lys  Pro Lys Gly 
    1250                 1255                 1260             


Tyr Phe  Ser Asp Ala Trp Asn  Xaa Phe Asp Ser Leu  Ile Val Ile 
    1265                 1270                 1275             


Gly Ser  Ile Ile Asp Val Ala  Leu Ser Glu Ala Asp  Pro Xaa Glu 
    1280                 1285                 1290             


Ser Glu  Asn Val Pro Val Pro  Xaa Ala Xaa Pro Gly  Asn Ser Glu 
    1295                 1300                 1305             


Glu Ser  Asn Arg Ile Ser Ile  Xaa Phe Phe Arg Leu  Phe Arg Val 
    1310                 1315                 1320             


Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Xaa 
    1325                 1330                 1335             


Leu Leu  Trp Xaa Phe Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val 
    1340                 1345                 1350             


Ala Leu  Leu Ile Ala Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly 
    1355                 1360                 1365             


Met Gln  Met Phe Gly Lys Val  Ala Met Arg Asp Asn  Asn Gln Ile 
    1370                 1375                 1380             


Asn Arg  Asn Asn Asn Phe Gln  Xaa Phe Pro Gln Ala  Val Leu Leu 
    1385                 1390                 1395             


Leu Phe  Arg Cys Ala Xaa Gly  Glu Ala Trp Gln Glu  Ile Met Leu 
    1400                 1405                 1410             


Ala Cys  Leu Pro Gly Lys Leu  Cys Asp Pro Glu Ser  Asp Tyr Asn 
    1415                 1420                 1425             


Pro Gly  Glu Glu Tyr Xaa Cys  Gly Ser Asn Phe Ala  Ile Val Tyr 
    1430                 1435                 1440             


Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu 
    1445                 1450                 1455             


Phe Val  Ala Val Ile Met Asp  Asn Phe Asp Tyr Leu  Xaa Arg Asp 
    1460                 1465                 1470             


Trp Ser  Ile Leu Gly Pro His  His Leu Asp Glu Phe  Lys Arg Ile 
    1475                 1480                 1485             


Trp Ser  Glu Tyr Asp Pro Glu  Ala Lys Gly Arg Ile  Lys His Leu 
    1490                 1495                 1500             


Asp Val  Val Xaa Leu Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe 
    1505                 1510                 1515             


Gly Lys  Leu Cys Pro His Arg  Val Ala Cys Lys Arg  Leu Val Ala 
    1520                 1525                 1530             


Met Asn  Met Pro Leu Asn Ser  Asp Gly Xaa Val Met  Phe Asn Ala 
    1535                 1540                 1545             


Xaa Leu  Phe Ala Leu Val Arg  Xaa Ala Leu Lys Ile  Lys Xaa Glu 
    1550                 1555                 1560             


Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu Arg Ala  Val Ile Lys 
    1565                 1570                 1575             


Lys Ile  Trp Lys Lys Xaa Ser  Met Lys Leu Leu Asp  Gln Val Val 
    1580                 1585                 1590             


Pro Pro  Ala Gly Asp Asp Glu  Val Xaa Val Gly Lys  Phe Tyr Ala 
    1595                 1600                 1605             


Xaa Phe  Leu Ile Gln Asp Tyr  Phe Arg Lys Phe Lys  Lys Arg Lys 
    1610                 1615                 1620             


Glu Gln  Gly Leu Val Gly Lys  Tyr Pro Ala Lys Asn  Xaa Xaa Ile 
    1625                 1630                 1635             


Ala Leu  Gln Ala Gly Leu Arg  Xaa Leu His Asp Ile  Gly Pro Glu 
    1640                 1645                 1650             


Ile Arg  Arg Ala Ile Ser Cys  Asp Leu Gln Asp Asp  Glu Pro Glu 
    1655                 1660                 1665             


Glu Xaa  Lys Arg Glu Glu Glu  Asp Asp Val Phe Lys  Arg Asn Gly 
    1670                 1675                 1680             


Ala Leu  Leu Gly Asn His Val  Asn His Val Asn Ser  Asp Arg Arg 
    1685                 1690                 1695             


Asp Ser  Leu Gln Gln Xaa Asn  Xaa Xaa His Arg Pro  Leu His Val 
    1700                 1705                 1710             


Gln Arg  Pro Ser Ile Pro Pro  Ala Ser Asp Xaa Glu  Lys Pro Leu 
    1715                 1720                 1725             


Phe Pro  Pro Ala Gly Asn Ser  Val Cys His Asn His  His Asn His 
    1730                 1735                 1740             


Asn Ser  Ile Gly Lys Gln Val  Pro Xaa Ser Xaa Asn  Ala Asn Leu 
    1745                 1750                 1755             


Asn Asn  Ala Asn Met Ser Lys  Ala Ala His Gly Lys  Arg Pro Ser 
    1760                 1765                 1770             


Ile Gly  Asn Leu Glu His Val  Ser Glu Asn Gly His  His Ser Ser 
    1775                 1780                 1785             


His Lys  His Asp Arg Glu Pro  Gln Arg Arg Ser Ser  Val Lys Arg 
    1790                 1795                 1800             


Xaa Arg  Tyr Tyr Glu Xaa Tyr  Ile Arg Ser Asp Ser  Gly Asp Glu 
    1805                 1810                 1815             


Gln Leu  Pro Xaa Ile Cys Arg  Glu Asp Pro Glu Ile  His Gly Tyr 
    1820                 1825                 1830             


Phe Arg  Asp Pro His Cys Leu  Gly Glu Gln Glu Tyr  Phe Ser Ser 
    1835                 1840                 1845             


Glu Glu  Cys Tyr Glu Asp Asp  Ser Ser Pro Xaa Trp  Ser Arg Gln 
    1850                 1855                 1860             


Asn Tyr  Gly Tyr Tyr Ser Arg  Tyr Pro Gly Arg Asn  Ile Asp Ser 
    1865                 1870                 1875             


Glu Arg  Pro Arg Gly Tyr His  His Pro Gln Gly Phe  Leu Glu Asp 
    1880                 1885                 1890             


Asp Asp  Ser Pro Val Cys Tyr  Asp Ser Arg Arg Ser  Pro Arg Arg 
    1895                 1900                 1905             


Arg Leu  Leu Pro Pro Xaa Pro  Ala Ser His Arg Arg  Ser Ser Phe 
    1910                 1915                 1920             


Asn Phe  Glu Cys Leu Arg Arg  Gln Ser Ser Gln Glu  Glu Val Pro 
    1925                 1930                 1935             


Ser Ser  Pro Ile Phe Pro His  Arg Xaa Ala Leu Pro  Leu His Leu 
    1940                 1945                 1950             


Met Gln  Gln Gln Ile Met Ala  Val Ala Gly Leu Asp  Ser Ser Lys 
    1955                 1960                 1965             


Ala Gln  Lys Tyr Ser Pro Ser  His Ser Xaa Arg Ser  Trp Ala Xaa 
    1970                 1975                 1980             


Pro Pro  Ala Xaa Pro Pro Tyr  Arg Asp Trp Xaa Pro  Cys Tyr Xaa 
    1985                 1990                 1995             


Pro Leu  Ile Gln Val Glu Gln  Ser Glu Ala Leu Asp  Gln Val Asn 
    2000                 2005                 2010             


Gly Ser  Leu Pro Ser Leu His  Arg Ser Ser Trp Tyr  Xaa Asp Glu 
    2015                 2020                 2025             


Pro Asp  Ile Ser Tyr Arg Xaa  Phe Xaa Pro Ala Ser  Leu Xaa Val 
    2030                 2035                 2040             


Pro Ser  Ser Phe Arg Asn Lys  Asn Ser Asp Lys Gln  Arg Ser Ala 
    2045                 2050                 2055             


Asp Ser  Leu Val Glu Ala Val  Leu Ile Ser Glu Gly  Leu Gly Arg 
    2060                 2065                 2070             


Tyr Ala  Arg Asp Pro Lys Phe  Val Ser Ala Xaa Lys  His Glu Ile 
    2075                 2080                 2085             


Ala Asp  Ala Cys Asp Leu Xaa  Ile Asp Glu Met Glu  Ser Ala Ala 
    2090                 2095                 2100             


Ser Xaa  Leu Leu Asn Gly Asn  Val Arg Pro Arg Ala  Asn Gly Asp 
    2105                 2110                 2115             


Val Gly  Pro Leu Ser His Arg  Gln Asp Tyr Glu Leu  Gln Asp Phe 
    2120                 2125                 2130             


Gly Pro  Gly Tyr Ser Asp Glu  Glu Pro Asp Pro Gly  Arg Asp Glu 
    2135                 2140                 2145             


Glu Asp  Leu Ala Asp Glu Met  Ile Cys Ile Xaa Xaa  Leu 
    2150                 2155                 2160     


<210> 4684
<211> 2181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1291)..(1291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1321)..(1321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1323)..(1323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1411)..(1411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1424)..(1424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1454)..(1454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1491)..(1491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1527)..(1527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1563)..(1563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1569)..(1569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1576)..(1576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1604)..(1604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1622)..(1622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1629)..(1629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1656)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1666)..(1666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1690)..(1690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1724)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1726)..(1727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1744)..(1744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1772)..(1772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1774)..(1774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1824)..(1824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1829)..(1829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1842)..(1842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1879)..(1879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1934)..(1934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1967)..(1967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1998)..(1998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2003)..(2003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2007)..(2007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2014)..(2014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2018)..(2018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2046)..(2046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2055)..(2055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2057)..(2057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2062)..(2062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2104)..(2104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2115)..(2115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2125)..(2125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2179)..(2180)
<223> Selenocysteine

<400> 4684
Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15      


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Xaa Arg Leu 
            20                  25                  30          


Pro Leu Ser Gly Glu Gly Pro Xaa Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45              


Xaa Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60                  


Ala Ala Gln Xaa Met Ser Xaa Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80  


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95      


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110         


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125             


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140                 


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Xaa Asn His Asn 
145                 150                 155                 160 


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Xaa Val Glu Xaa 
                165                 170                 175     


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190         


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205             


Leu Phe Ser Val Ile Leu Glu Gln Leu Xaa Lys Glu Xaa Glu Gly Gly 
    210                 215                 220                 


Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
225                 230                 235                 240 


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                245                 250                 255     


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
            260                 265                 270         


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
        275                 280                 285             


Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Xaa Cys Phe Phe Ala 
    290                 295                 300                 


Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
305                 310                 315                 320 


Gly Asn Gly Arg Gln Cys Xaa Ala Asn Gly Xaa Glu Cys Arg Ser Gly 
                325                 330                 335     


Trp Val Gly Pro Asn Gly Gly Ile Xaa Asn Phe Asp Asn Phe Ala Phe 
            340                 345                 350         


Ala Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly Trp Xaa Asp 
        355                 360                 365             


Val Leu Tyr Trp Val Asn Asp Ala Ile Gly Trp Glu Trp Pro Trp Val 
    370                 375                 380                 


Tyr Phe Val Ser Leu Ile Ile Leu Gly Ser Phe Phe Val Leu Asn Leu 
385                 390                 395                 400 


Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                405                 410                 415     


Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
            420                 425                 430         


Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Asp Ile 
        435                 440                 445             


Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Xaa 
    450                 455                 460                 


Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn Val Ser 
465                 470                 475                 480 


Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Trp Cys Trp Trp 
                485                 490                 495     


Arg Arg Arg Gly Ala Ala Lys Ala Gly Pro Ser Gly Cys Arg Arg Trp 
            500                 505                 510         


Gly Gln Ala Ile Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp 
        515                 520                 525             


Asn Arg Phe Asn Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Xaa 
    530                 535                 540                 


Phe Tyr Trp Leu Val Ile Val Leu Val Phe Leu Asn Xaa Leu Xaa Ile 
545                 550                 555                 560 


Ser Ser Glu His Tyr Asn Gln Pro Asp Trp Leu Xaa Gln Ile Gln Asp 
                565                 570                 575     


Ile Ala Asn Lys Val Leu Leu Ala Leu Phe Xaa Cys Glu Met Leu Val 
            580                 585                 590         


Lys Met Tyr Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn 
        595                 600                 605             


Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Xaa Glu Xaa Ile Leu 
    610                 615                 620                 


Val Glu Leu Glu Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys 
625                 630                 635                 640 


Val Arg Leu Leu Arg Ile Phe Lys Val Xaa Arg His Trp Xaa Ser Leu 
                645                 650                 655     


Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Met Lys Ser Ile Ala Ser 
            660                 665                 670         


Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly 
        675                 680                 685             


Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Glu Xaa Gln Xaa Lys 
    690                 695                 700                 


Arg Ser Xaa Phe Asp Asn Phe Pro Gln Ala Leu Leu Xaa Val Phe Gln 
705                 710                 715                 720 


Ile Leu Xaa Gly Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met 
                725                 730                 735     


Ala Tyr Gly Gly Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe 
            740                 745                 750         


Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu 
        755                 760                 765             


Ala Ile Ala Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Xaa Ala 
    770                 775                 780                 


Gln Lys Glu Glu Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys 
785                 790                 795                 800 


Glu Ser Leu Glu Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile 
                805                 810                 815     


Ala Asn Ser Asp Asn Lys Val Xaa Ile Asp Asp Tyr Arg Glu Glu Asp 
            820                 825                 830         


Glu Asp Lys Asp Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg 
    850                 855                 860                 


Pro Arg Arg Ile Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile 
865                 870                 875                 880 


Pro Glu Gly Ser Ala Phe Phe Ile Leu Ser Lys Xaa Asn Pro Ile Arg 
                885                 890                 895     


Val Gly Cys His Lys Leu Ile Asn His His Ile Phe Xaa Asn Leu Ile 
            900                 905                 910         


Leu Val Phe Ile Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro 
        915                 920                 925             


Ile Arg Ser His Ser Phe Arg Asn Xaa Ile Leu Gly Tyr Phe Asp Tyr 
    930                 935                 940                 


Ala Phe Xaa Ala Ile Phe Xaa Val Glu Ile Leu Leu Lys Met Xaa Xaa 
945                 950                 955                 960 


Phe Gly Ala Phe Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn 
                965                 970                 975     


Leu Leu Asp Met Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile 
            980                 985                 990         


Gln Ser Ser Ala Ile Ser Val Val  Lys Ile Leu Arg Val  Leu Arg Val 
        995                 1000                 1005             


Leu Arg  Pro Leu Arg Ala Ile  Asn Arg Ala Lys Gly  Leu Lys His 
    1010                 1015                 1020             


Val Val  Gln Cys Val Phe Val  Ala Ile Arg Xaa Ile  Gly Asn Ile 
    1025                 1030                 1035             


Met Ile  Val Xaa Xaa Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly 
    1040                 1045                 1050             


Val Gln  Leu Phe Lys Gly Lys  Phe Tyr Arg Cys Xaa  Asp Glu Ala 
    1055                 1060                 1065             


Lys Ser  Asn Pro Glu Glu Cys  Arg Gly Leu Phe Ile  Leu Tyr Lys 
    1070                 1075                 1080             


Asp Gly  Asp Val Asp Ser Pro  Val Val Arg Glu Arg  Ile Trp Gln 
    1085                 1090                 1095             


Asn Ser  Asp Phe Asn Phe Asp  Asn Val Leu Ser Ala  Met Met Ala 
    1100                 1105                 1110             


Leu Phe  Xaa Val Ser Xaa Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr 
    1115                 1120                 1125             


Lys Ala  Ile Asp Ser Asn Gly  Glu Asn Ile Gly Pro  Ile Tyr Asn 
    1130                 1135                 1140             


His Arg  Val Glu Ile Ser Ile  Phe Phe Ile Ile Tyr  Ile Ile Ile 
    1145                 1150                 1155             


Val Ala  Phe Phe Met Met Asn  Ile Phe Val Gly Phe  Val Ile Val 
    1160                 1165                 1170             


Xaa Phe  Gln Glu Gln Gly Glu  Lys Glu Tyr Lys Asn  Cys Glu Leu 
    1175                 1180                 1185             


Asp Lys  Asn Gln Arg Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Arg 
    1190                 1195                 1200             


Pro Leu  Arg Arg Tyr Ile Pro  Lys Asn Pro Tyr Gln  Tyr Lys Phe 
    1205                 1210                 1215             


Trp Tyr  Val Val Asn Ser Ser  Pro Phe Glu Tyr Met  Met Phe Val 
    1220                 1225                 1230             


Leu Ile  Met Leu Asn Xaa Leu  Cys Leu Ala Met Gln  His Tyr Glu 
    1235                 1240                 1245             


Gln Ser  Lys Met Phe Asn Asp  Ala Met Asp Ile Leu  Asn Met Val 
    1250                 1255                 1260             


Phe Xaa  Gly Val Phe Xaa Val  Glu Met Val Leu Lys  Val Ile Ala 
    1265                 1270                 1275             


Phe Lys  Pro Lys Gly Tyr Phe  Ser Asp Ala Trp Asn  Xaa Phe Asp 
    1280                 1285                 1290             


Ser Leu  Ile Val Ile Gly Ser  Ile Ile Asp Val Ala  Leu Ser Glu 
    1295                 1300                 1305             


Ala Asp  Pro Xaa Glu Ser Glu  Asn Val Pro Val Pro  Xaa Ala Xaa 
    1310                 1315                 1320             


Pro Gly  Asn Ser Glu Glu Ser  Asn Arg Ile Ser Ile  Xaa Phe Phe 
    1325                 1330                 1335             


Arg Leu  Phe Arg Val Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly 
    1340                 1345                 1350             


Glu Gly  Ile Arg Xaa Leu Leu  Trp Xaa Phe Ile Lys  Ser Phe Gln 
    1355                 1360                 1365             


Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Ala Met Leu  Phe Phe Ile 
    1370                 1375                 1380             


Tyr Ala  Val Ile Gly Met Gln  Met Phe Gly Lys Val  Ala Met Arg 
    1385                 1390                 1395             


Asp Asn  Asn Gln Ile Asn Arg  Asn Asn Asn Phe Gln  Xaa Phe Pro 
    1400                 1405                 1410             


Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala Xaa Gly  Glu Ala Trp 
    1415                 1420                 1425             


Gln Glu  Ile Met Leu Ala Cys  Leu Pro Gly Lys Leu  Cys Asp Pro 
    1430                 1435                 1440             


Glu Ser  Asp Tyr Asn Pro Gly  Glu Glu Tyr Xaa Cys  Gly Ser Asn 
    1445                 1450                 1455             


Phe Ala  Ile Val Tyr Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe 
    1460                 1465                 1470             


Leu Ile  Ile Asn Leu Phe Val  Ala Val Ile Met Asp  Asn Phe Asp 
    1475                 1480                 1485             


Tyr Leu  Xaa Arg Asp Trp Ser  Ile Leu Gly Pro His  His Leu Asp 
    1490                 1495                 1500             


Glu Phe  Lys Arg Ile Trp Ser  Glu Tyr Asp Pro Glu  Ala Lys Gly 
    1505                 1510                 1515             


Arg Ile  Lys His Leu Asp Val  Val Xaa Leu Leu Arg  Arg Ile Gln 
    1520                 1525                 1530             


Pro Pro  Leu Gly Phe Gly Lys  Leu Cys Pro His Arg  Val Ala Cys 
    1535                 1540                 1545             


Lys Arg  Leu Val Ala Met Asn  Met Pro Leu Asn Ser  Asp Gly Xaa 
    1550                 1555                 1560             


Val Met  Phe Asn Ala Xaa Leu  Phe Ala Leu Val Arg  Xaa Ala Leu 
    1565                 1570                 1575             


Lys Ile  Lys Xaa Glu Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu 
    1580                 1585                 1590             


Arg Ala  Val Ile Lys Lys Ile  Trp Lys Lys Xaa Ser  Met Lys Leu 
    1595                 1600                 1605             


Leu Asp  Gln Val Val Pro Pro  Ala Gly Asp Asp Glu  Val Xaa Val 
    1610                 1615                 1620             


Gly Lys  Phe Tyr Ala Xaa Phe  Leu Ile Gln Asp Tyr  Phe Arg Lys 
    1625                 1630                 1635             


Phe Lys  Lys Arg Lys Glu Gln  Gly Leu Val Gly Lys  Tyr Pro Ala 
    1640                 1645                 1650             


Lys Asn  Xaa Xaa Ile Ala Leu  Gln Ala Gly Leu Arg  Xaa Leu His 
    1655                 1660                 1665             


Asp Ile  Gly Pro Glu Ile Arg  Arg Ala Ile Ser Cys  Asp Leu Gln 
    1670                 1675                 1680             


Asp Asp  Glu Pro Glu Glu Xaa  Lys Arg Glu Glu Glu  Asp Asp Val 
    1685                 1690                 1695             


Phe Lys  Arg Asn Gly Ala Leu  Leu Gly Asn His Val  Asn His Val 
    1700                 1705                 1710             


Asn Ser  Asp Arg Arg Asp Ser  Leu Gln Gln Xaa Asn  Xaa Xaa His 
    1715                 1720                 1725             


Arg Pro  Leu His Val Gln Arg  Pro Ser Ile Pro Pro  Ala Ser Asp 
    1730                 1735                 1740             


Xaa Glu  Lys Pro Leu Phe Pro  Pro Ala Gly Asn Ser  Val Cys His 
    1745                 1750                 1755             


Asn His  His Asn His Asn Ser  Ile Gly Lys Gln Val  Pro Xaa Ser 
    1760                 1765                 1770             


Xaa Asn  Ala Asn Leu Asn Asn  Ala Asn Met Ser Lys  Ala Ala His 
    1775                 1780                 1785             


Gly Lys  Arg Pro Ser Ile Gly  Asn Leu Glu His Val  Ser Glu Asn 
    1790                 1795                 1800             


Gly His  His Ser Ser His Lys  His Asp Arg Glu Pro  Gln Arg Arg 
    1805                 1810                 1815             


Ser Ser  Val Lys Arg Xaa Arg  Tyr Tyr Glu Xaa Tyr  Ile Arg Ser 
    1820                 1825                 1830             


Asp Ser  Gly Asp Glu Gln Leu  Pro Xaa Ile Cys Arg  Glu Asp Pro 
    1835                 1840                 1845             


Glu Ile  His Gly Tyr Phe Arg  Asp Pro His Cys Leu  Gly Glu Gln 
    1850                 1855                 1860             


Glu Tyr  Phe Ser Ser Glu Glu  Cys Tyr Glu Asp Asp  Ser Ser Pro 
    1865                 1870                 1875             


Xaa Trp  Ser Arg Gln Asn Tyr  Gly Tyr Tyr Ser Arg  Tyr Pro Gly 
    1880                 1885                 1890             


Arg Asn  Ile Asp Ser Glu Arg  Pro Arg Gly Tyr His  His Pro Gln 
    1895                 1900                 1905             


Gly Phe  Leu Glu Asp Asp Asp  Ser Pro Val Cys Tyr  Asp Ser Arg 
    1910                 1915                 1920             


Arg Ser  Pro Arg Arg Arg Leu  Leu Pro Pro Xaa Pro  Ala Ser His 
    1925                 1930                 1935             


Arg Arg  Ser Ser Phe Asn Phe  Glu Cys Leu Arg Arg  Gln Ser Ser 
    1940                 1945                 1950             


Gln Glu  Glu Val Pro Ser Ser  Pro Ile Phe Pro His  Arg Xaa Ala 
    1955                 1960                 1965             


Leu Pro  Leu His Leu Met Gln  Gln Gln Ile Met Ala  Val Ala Gly 
    1970                 1975                 1980             


Leu Asp  Ser Ser Lys Ala Gln  Lys Tyr Ser Pro Ser  His Ser Xaa 
    1985                 1990                 1995             


Arg Ser  Trp Ala Xaa Pro Pro  Ala Xaa Pro Pro Tyr  Arg Asp Trp 
    2000                 2005                 2010             


Xaa Pro  Cys Tyr Xaa Pro Leu  Ile Gln Val Glu Gln  Ser Glu Ala 
    2015                 2020                 2025             


Leu Asp  Gln Val Asn Gly Ser  Leu Pro Ser Leu His  Arg Ser Ser 
    2030                 2035                 2040             


Trp Tyr  Xaa Asp Glu Pro Asp  Ile Ser Tyr Arg Xaa  Phe Xaa Pro 
    2045                 2050                 2055             


Ala Ser  Leu Xaa Val Pro Ser  Ser Phe Arg Asn Lys  Asn Ser Asp 
    2060                 2065                 2070             


Lys Gln  Arg Ser Ala Asp Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2075                 2080                 2085             


Glu Gly  Leu Gly Arg Tyr Ala  Arg Asp Pro Lys Phe  Val Ser Ala 
    2090                 2095                 2100             


Xaa Lys  His Glu Ile Ala Asp  Ala Cys Asp Leu Xaa  Ile Asp Glu 
    2105                 2110                 2115             


Met Glu  Ser Ala Ala Ser Xaa  Leu Leu Asn Gly Asn  Val Arg Pro 
    2120                 2125                 2130             


Arg Ala  Asn Gly Asp Val Gly  Pro Leu Ser His Arg  Gln Asp Tyr 
    2135                 2140                 2145             


Glu Leu  Gln Asp Phe Gly Pro  Gly Tyr Ser Asp Glu  Glu Pro Asp 
    2150                 2155                 2160             


Pro Gly  Arg Asp Glu Glu Asp  Leu Ala Asp Glu Met  Ile Cys Ile 
    2165                 2170                 2175             


Xaa Xaa  Leu 
    2180     


<210> 4685
<211> 490
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(480)
<223> Selenocysteine

<400> 4685
Met Met Asn Ile Phe Val Gly Phe Val Ile Val Xaa Phe Gln Glu Gln 
1               5                   10                  15      


Gly Glu Lys Glu Tyr Lys Asn Cys Glu Leu Asp Lys Asn Gln Arg Gln 
            20                  25                  30          


Cys Val Glu Tyr Ala Leu Lys Ala Arg Pro Leu Arg Arg Tyr Ile Pro 
        35                  40                  45              


Lys Asn Pro Tyr Gln Tyr Lys Phe Trp Tyr Val Val Asn Ser Ser Pro 
    50                  55                  60                  


Phe Glu Tyr Met Met Phe Val Leu Ile Met Leu Asn Xaa Leu Cys Leu 
65                  70                  75                  80  


Ala Met Gln His Tyr Glu Gln Ser Lys Met Phe Asn Asp Ala Met Asp 
                85                  90                  95      


Ile Leu Asn Met Val Phe Xaa Gly Val Phe Xaa Val Glu Met Val Leu 
            100                 105                 110         


Lys Val Ile Ala Phe Lys Pro Lys Gly Tyr Phe Ser Asp Ala Trp Asn 
        115                 120                 125             


Xaa Phe Asp Ser Leu Ile Val Ile Gly Ser Ile Ile Asp Val Ala Leu 
    130                 135                 140                 


Ser Glu Ala Asp Asn Ser Glu Glu Ser Asn Arg Ile Ser Ile Xaa Phe 
145                 150                 155                 160 


Phe Arg Leu Phe Arg Val Met Arg Leu Val Lys Leu Leu Ser Arg Gly 
                165                 170                 175     


Glu Gly Ile Arg Xaa Leu Leu Trp Xaa Phe Ile Lys Ser Phe Gln Ala 
            180                 185                 190         


Leu Pro Tyr Val Ala Leu Leu Ile Ala Met Leu Phe Phe Ile Tyr Ala 
        195                 200                 205             


Val Ile Gly Met Gln Met Phe Gly Lys Val Ala Met Arg Asp Asn Asn 
    210                 215                 220                 


Gln Ile Asn Arg Asn Asn Asn Phe Gln Xaa Phe Pro Gln Ala Val Leu 
225                 230                 235                 240 


Leu Leu Phe Arg Cys Ala Xaa Gly Glu Ala Trp Gln Glu Ile Met Leu 
                245                 250                 255     


Ala Cys Leu Pro Gly Lys Leu Cys Asp Pro Glu Ser Asp Tyr Asn Pro 
            260                 265                 270         


Gly Glu Glu Tyr Xaa Cys Gly Ser Asn Phe Ala Ile Val Tyr Phe Ile 
        275                 280                 285             


Ser Phe Tyr Met Leu Cys Ala Phe Leu Ile Ile Asn Leu Phe Val Ala 
    290                 295                 300                 


Val Ile Met Asp Asn Phe Asp Tyr Leu Xaa Arg Asp Trp Ser Ile Leu 
305                 310                 315                 320 


Gly Pro His His Leu Asp Glu Phe Lys Arg Ile Trp Ser Glu Tyr Asp 
                325                 330                 335     


Pro Glu Ala Lys Gly Arg Ile Lys His Leu Asp Val Val Xaa Leu Leu 
            340                 345                 350         


Arg Arg Ile Gln Pro Pro Leu Gly Phe Gly Lys Leu Cys Pro His Arg 
        355                 360                 365             


Val Ala Cys Lys Arg Leu Val Ala Met Asn Met Pro Leu Asn Ser Asp 
    370                 375                 380                 


Gly Xaa Val Met Phe Asn Ala Xaa Leu Phe Ala Leu Val Arg Xaa Ala 
385                 390                 395                 400 


Leu Lys Ile Lys Xaa Glu Gly Asn Leu Glu Gln Ala Asn Glu Glu Leu 
                405                 410                 415     


Arg Ala Val Ile Lys Lys Ile Trp Lys Lys Xaa Ser Met Lys Leu Leu 
            420                 425                 430         


Asp Gln Val Val Pro Pro Ala Gly Asp Asp Glu Val Xaa Val Gly Lys 
        435                 440                 445             


Phe Tyr Ala Xaa Phe Leu Ile Gln Asp Tyr Phe Arg Lys Phe Lys Lys 
    450                 455                 460                 


Arg Lys Glu Gln Gly Leu Val Gly Lys Tyr Pro Ala Lys Asn Xaa Xaa 
465                 470                 475                 480 


Ile Ala Leu Gln Met Leu Glu Arg Met Leu 
                485                 490 


<210> 4686
<211> 297
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<400> 4686
Xaa Ala Asp Ala Glu Ser Leu Asn Xaa Ala Gln Lys Glu Glu Ala Glu 
1               5                   10                  15      


Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys Glu Ser Leu Glu Asn Lys 
            20                  25                  30          


Lys Asn Asn Lys Pro Glu Val Asn Gln Ile Ala Asn Ser Asp Asn Lys 
        35                  40                  45              


Val Xaa Ile Asp Asp Tyr Arg Glu Glu Asp Glu Asp Lys Asp Pro Tyr 
    50                  55                  60                  


Pro Pro Cys Asp Val Pro Gly Glu Glu Glu Glu Glu Glu Glu Glu Asp 
65                  70                  75                  80  


Glu Pro Glu Val Pro Ala Gly Pro Arg Pro Arg Arg Ile Ser Glu Leu 
                85                  90                  95      


Asn Met Lys Glu Lys Ile Ala Pro Ile Pro Glu Gly Ser Ala Phe Phe 
            100                 105                 110         


Ile Leu Ser Lys Xaa Asn Pro Ile Arg Val Gly Cys His Lys Leu Ile 
        115                 120                 125             


Asn His His Ile Phe Xaa Asn Leu Ile Leu Val Phe Ile Met Leu Ser 
    130                 135                 140                 


Ser Ala Ala Leu Ala Ala Glu Asp Pro Ile Arg Ser His Ser Phe Arg 
145                 150                 155                 160 


Asn Xaa Met Leu Gly Tyr Ala Asp Tyr Val Phe Xaa Gly Xaa Phe Ala 
                165                 170                 175     


Phe Glu Ile Ile Leu Lys Met Xaa Xaa Phe Gly Ala Phe Leu His Lys 
            180                 185                 190         


Gly Ala Phe Cys Arg Asn Tyr Phe Asn Leu Leu Asp Met Leu Val Val 
        195                 200                 205             


Gly Val Ser Leu Val Ser Phe Gly Ile Gln Ser Ser Ala Ile Ser Val 
    210                 215                 220                 


Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu Arg Ala Ile 
225                 230                 235                 240 


Asn Arg Ala Lys Gly Leu Lys His Val Val Gln Cys Val Phe Val Ala 
                245                 250                 255     


Ile Arg Xaa Ile Gly Asn Ile Met Ile Val Xaa Xaa Leu Leu Gln Phe 
            260                 265                 270         


Met Phe Ala Cys Ile Gly Val Gln Leu Phe Lys Gly Lys Phe Tyr Arg 
        275                 280                 285             


Cys Xaa Asp Glu Ala Lys Ser Asn Pro 
    290                 295         


<210> 4687
<211> 284
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<400> 4687
Xaa Phe Tyr Arg Cys Xaa Asp Glu Ala Lys Ser Asn Pro Glu Glu Cys 
1               5                   10                  15      


Arg Gly Leu Phe Ile Leu Tyr Lys Asp Gly Asp Val Asp Ser Pro Val 
            20                  25                  30          


Val Arg Glu Arg Ile Trp Gln Asn Ser Asp Phe Asn Phe Asp Asn Val 
        35                  40                  45              


Leu Ser Ala Met Met Ala Leu Phe Xaa Val Ser Xaa Phe Glu Gly Trp 
    50                  55                  60                  


Pro Ala Leu Leu Tyr Lys Ala Ile Asp Ser Asn Gly Glu Asn Ile Gly 
65                  70                  75                  80  


Pro Ile Tyr Asn His Arg Val Glu Ile Ser Ile Phe Phe Ile Ile Tyr 
                85                  90                  95      


Ile Ile Ile Val Ala Phe Phe Met Met Asn Ile Phe Val Gly Phe Val 
            100                 105                 110         


Ile Val Xaa Phe Gln Glu Gln Gly Glu Lys Glu Tyr Lys Asn Cys Glu 
        115                 120                 125             


Leu Asp Lys Asn Gln Arg Gln Cys Val Glu Tyr Ala Leu Lys Ala Arg 
    130                 135                 140                 


Pro Leu Arg Arg Tyr Ile Pro Lys Asn Pro Tyr Gln Tyr Lys Phe Trp 
145                 150                 155                 160 


Tyr Val Val Asn Ser Ser Pro Phe Glu Tyr Met Met Phe Val Leu Ile 
                165                 170                 175     


Met Leu Asn Xaa Leu Cys Leu Ala Met Gln His Tyr Glu Gln Ser Lys 
            180                 185                 190         


Met Phe Asn Asp Ala Met Asp Ile Leu Asn Met Val Phe Xaa Gly Val 
        195                 200                 205             


Phe Xaa Val Glu Met Val Leu Lys Val Ile Ala Phe Lys Pro Lys Asn 
    210                 215                 220                 


Ser Glu Glu Ser Asn Arg Ile Ser Ile Xaa Phe Phe Arg Leu Phe Arg 
225                 230                 235                 240 


Val Met Arg Leu Val Lys Leu Leu Ser Arg Gly Glu Gly Ile Arg Xaa 
                245                 250                 255     


Leu Leu Trp Xaa Phe Ile Lys Ser Phe Gln Ala Leu Pro Tyr Val Ala 
            260                 265                 270         


Leu Leu Ile Ala Met Leu Phe Phe Ile Tyr Ala Val 
        275                 280                 


<210> 4688
<211> 264
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<400> 4688
Xaa Pro Cys Ala Phe Ser Gly Asn Gly Arg Gln Cys Xaa Ala Asn Gly 
1               5                   10                  15      


Xaa Glu Cys Arg Ser Gly Trp Val Gly Pro Asn Gly Gly Ile Xaa Asn 
            20                  25                  30          


Phe Asp Asn Phe Ala Phe Ala Met Leu Xaa Val Phe Gln Cys Ile Xaa 
        35                  40                  45              


Met Glu Gly Trp Xaa Asp Val Leu Tyr Trp Val Asn Asp Ala Ile Gly 
    50                  55                  60                  


Trp Glu Trp Pro Trp Val Tyr Phe Val Ser Leu Ile Ile Leu Gly Ser 
65                  70                  75                  80  


Phe Phe Val Leu Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ser 
                85                  90                  95      


Lys Glu Arg Glu Lys Ala Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg 
            100                 105                 110         


Glu Lys Gln Gln Leu Glu Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile 
        115                 120                 125             


Xaa Gln Ala Glu Asp Ile Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu 
    130                 135                 140                 


Glu Gly Lys Arg Asn Arg Val Xaa Val Ala Asp Leu Leu Lys Glu Asp 
145                 150                 155                 160 


Lys Lys Lys Lys Lys Phe Cys Cys Phe Arg Gln Arg Arg Ala Lys Asp 
                165                 170                 175     


His Ala Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu Asn 
            180                 185                 190         


Val Ser Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Cys Gln 
        195                 200                 205             


Ala Ile Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp Asn Arg 
    210                 215                 220                 


Phe Asn Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Xaa Phe Tyr 
225                 230                 235                 240 


Trp Leu Val Ile Val Leu Val Phe Leu Asn Xaa Leu Xaa Ile Ser Ser 
                245                 250                 255     


Glu His Tyr Asn Gln Pro Asp Trp 
            260                 


<210> 4689
<211> 1372
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1083)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1105)..(1105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1238)..(1238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1316)..(1316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1323)..(1323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1329)..(1329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<400> 4689
Xaa Pro Ser Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val 
1               5                   10                  15      


Pro Leu Leu His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr 
            20                  25                  30          


Ala Ile Ile Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Xaa Cys 
        35                  40                  45              


Phe Phe Ala Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys 
    50                  55                  60                  


Ala Phe Ser Gly Asn Gly Arg Gln Cys Xaa Ala Asn Gly Xaa Glu Cys 
65                  70                  75                  80  


Arg Ser Gly Trp Val Gly Pro Asn Gly Gly Ile Xaa Asn Phe Asp Asn 
                85                  90                  95      


Phe Ala Phe Ala Met Leu Xaa Val Phe Gln Cys Ile Xaa Met Glu Gly 
            100                 105                 110         


Trp Xaa Asp Val Leu Tyr Trp Val Asn Asp Ala Ile Gly Trp Glu Trp 
        115                 120                 125             


Pro Trp Val Tyr Phe Val Ser Leu Ile Ile Leu Gly Ser Phe Phe Val 
    130                 135                 140                 


Leu Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg 
145                 150                 155                 160 


Glu Lys Ala Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln 
                165                 170                 175     


Gln Leu Glu Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Xaa Gln Ala 
            180                 185                 190         


Glu Asp Ile Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys 
        195                 200                 205             


Arg Asn Xaa Ser Met Pro Xaa Ser Glu Xaa Glu Ser Val Asn Xaa Glu 
    210                 215                 220                 


Asn Val Ser Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Trp 
225                 230                 235                 240 


Cys Trp Trp Arg Arg Arg Gly Ala Ala Lys Ala Gly Pro Ser Gly Cys 
                245                 250                 255     


Arg Arg Trp Gly Gln Ala Ile Ser Lys Ser Lys Leu Ser Arg Arg Trp 
            260                 265                 270         


Arg Arg Trp Asn Arg Phe Asn Arg Arg Arg Cys Arg Ala Ala Val Lys 
        275                 280                 285             


Ser Val Xaa Phe Tyr Trp Leu Val Ile Val Leu Val Phe Leu Asn Xaa 
    290                 295                 300                 


Leu Xaa Ile Ser Ser Glu His Tyr Asn Gln Pro Asp Trp Leu Xaa Gln 
305                 310                 315                 320 


Ile Gln Asp Ile Ala Asn Lys Val Leu Leu Ala Leu Phe Xaa Cys Glu 
                325                 330                 335     


Met Leu Val Lys Met Tyr Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser 
            340                 345                 350         


Leu Phe Asn Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Xaa Glu 
        355                 360                 365             


Xaa Ile Leu Val Glu Leu Glu Ile Met Ser Pro Leu Gly Ile Ser Val 
    370                 375                 380                 


Phe Arg Cys Val Arg Leu Leu Arg Ile Phe Lys Val Xaa Arg His Trp 
385                 390                 395                 400 


Xaa Ser Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Met Lys Ser 
                405                 410                 415     


Ile Ala Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser 
            420                 425                 430         


Leu Leu Gly Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Glu Xaa 
        435                 440                 445             


Gln Xaa Lys Arg Ser Xaa Phe Asp Asn Phe Pro Gln Ala Leu Leu Xaa 
    450                 455                 460                 


Val Phe Gln Ile Leu Xaa Gly Glu Asp Trp Asn Ala Val Met Tyr Asp 
465                 470                 475                 480 


Gly Ile Met Ala Tyr Gly Gly Pro Ser Ser Ser Gly Met Ile Val Cys 
                485                 490                 495     


Ile Tyr Phe Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn 
            500                 505                 510         


Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asp Ala Glu Ser Leu 
        515                 520                 525             


Asn Xaa Ala Gln Lys Glu Glu Ala Glu Glu Lys Glu Arg Lys Lys Ile 
    530                 535                 540                 


Ala Arg Lys Glu Ser Leu Glu Asn Lys Lys Asn Asn Lys Pro Glu Val 
545                 550                 555                 560 


Asn Gln Ile Ala Asn Ser Asp Asn Lys Val Xaa Ile Asp Asp Tyr Arg 
                565                 570                 575     


Glu Glu Asp Glu Asp Lys Asp Pro Tyr Pro Pro Cys Asp Val Pro Val 
            580                 585                 590         


Gly Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Pro Glu Val Pro Ala 
        595                 600                 605             


Gly Pro Arg Pro Arg Arg Ile Ser Glu Leu Asn Met Lys Glu Lys Ile 
    610                 615                 620                 


Ala Pro Ile Pro Glu Gly Ser Ala Phe Phe Ile Leu Ser Lys Xaa Asn 
625                 630                 635                 640 


Pro Ile Arg Val Gly Cys His Lys Leu Ile Asn His His Ile Phe Xaa 
                645                 650                 655     


Asn Leu Ile Leu Val Phe Ile Met Leu Ser Ser Ala Ala Leu Ala Ala 
            660                 665                 670         


Glu Asp Pro Ile Arg Ser His Ser Phe Arg Asn Xaa Ile Leu Gly Tyr 
        675                 680                 685             


Phe Asp Tyr Ala Phe Xaa Ala Ile Phe Xaa Val Glu Ile Leu Leu Lys 
    690                 695                 700                 


Met Xaa Xaa Phe Gly Ala Phe Leu His Lys Gly Ala Phe Cys Arg Asn 
705                 710                 715                 720 


Tyr Phe Asn Leu Leu Asp Met Leu Val Val Gly Val Ser Leu Val Ser 
                725                 730                 735     


Phe Gly Ile Gln Ser Ser Ala Ile Ser Val Val Lys Ile Leu Arg Val 
            740                 745                 750         


Leu Arg Val Leu Arg Pro Leu Arg Ala Ile Asn Arg Ala Lys Gly Leu 
        755                 760                 765             


Lys His Val Val Gln Cys Val Phe Val Ala Ile Arg Xaa Ile Gly Asn 
    770                 775                 780                 


Ile Met Ile Val Xaa Xaa Leu Leu Gln Phe Met Phe Ala Cys Ile Gly 
785                 790                 795                 800 


Val Gln Leu Phe Lys Gly Lys Phe Tyr Arg Cys Xaa Asp Glu Ala Lys 
                805                 810                 815     


Ser Asn Pro Glu Glu Cys Arg Gly Leu Phe Ile Leu Tyr Lys Asp Gly 
            820                 825                 830         


Asp Val Asp Ser Pro Val Val Arg Glu Arg Ile Trp Gln Asn Ser Asp 
        835                 840                 845             


Phe Asn Phe Asp Asn Val Leu Ser Ala Met Met Ala Leu Phe Xaa Val 
    850                 855                 860                 


Ser Xaa Phe Glu Gly Trp Pro Ala Leu Leu Tyr Lys Ala Ile Asp Ser 
865                 870                 875                 880 


Asn Gly Glu Asn Ile Gly Pro Ile Tyr Asn His Arg Val Glu Ile Ser 
                885                 890                 895     


Ile Phe Phe Ile Ile Tyr Ile Ile Ile Val Ala Phe Phe Met Met Asn 
            900                 905                 910         


Ile Phe Val Gly Phe Val Ile Val Xaa Phe Gln Glu Gln Gly Glu Lys 
        915                 920                 925             


Glu Tyr Lys Asn Cys Glu Leu Asp Lys Asn Gln Arg Gln Cys Val Glu 
    930                 935                 940                 


Tyr Ala Leu Lys Ala Arg Pro Leu Arg Arg Tyr Ile Pro Lys Asn Pro 
945                 950                 955                 960 


Tyr Gln Tyr Lys Phe Trp Tyr Val Val Asn Ser Ser Pro Phe Glu Tyr 
                965                 970                 975     


Met Met Phe Val Leu Ile Met Leu Asn Xaa Leu Cys Leu Ala Met Gln 
            980                 985                 990         


His Tyr Glu Gln Ser Lys Met Phe  Asn Asp Ala Met Asp  Ile Leu Asn 
        995                 1000                 1005             


Met Val  Phe Xaa Gly Val Phe  Xaa Val Glu Met Val  Leu Lys Val 
    1010                 1015                 1020             


Ile Ala  Phe Lys Pro Lys His  Tyr Phe Xaa Asp Ala  Trp Asn Xaa 
    1025                 1030                 1035             


Phe Asp  Ala Leu Ile Val Val  Gly Ser Val Val Asp  Ile Ala Ile 
    1040                 1045                 1050             


Xaa Glu  Val Asn Pro Xaa Glu  Ser Glu Asn Val Pro  Val Pro Xaa 
    1055                 1060                 1065             


Ala Xaa  Pro Gly Asn Ser Glu  Glu Ser Asn Arg Ile  Ser Ile Xaa 
    1070                 1075                 1080             


Phe Phe  Arg Leu Phe Arg Val  Met Arg Leu Val Lys  Leu Leu Ser 
    1085                 1090                 1095             


Arg Gly  Glu Gly Ile Arg Xaa  Leu Leu Trp Xaa Phe  Ile Lys Ser 
    1100                 1105                 1110             


Phe Gln  Ala Leu Pro Tyr Val  Ala Leu Leu Ile Ala  Met Leu Phe 
    1115                 1120                 1125             


Phe Ile  Tyr Ala Val Ile Gly  Met Gln Met Phe Gly  Lys Val Ala 
    1130                 1135                 1140             


Met Arg  Asp Asn Asn Gln Ile  Asn Arg Asn Asn Asn  Phe Gln Xaa 
    1145                 1150                 1155             


Phe Pro  Gln Ala Val Leu Leu  Leu Phe Arg Cys Ala  Xaa Gly Glu 
    1160                 1165                 1170             


Ala Trp  Gln Glu Ile Met Leu  Ala Cys Leu Pro Gly  Lys Leu Cys 
    1175                 1180                 1185             


Asp Pro  Glu Ser Asp Tyr Asn  Pro Gly Glu Glu Tyr  Xaa Cys Gly 
    1190                 1195                 1200             


Ser Asn  Phe Ala Ile Val Tyr  Phe Ile Ser Phe Tyr  Met Leu Cys 
    1205                 1210                 1215             


Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala Val Ile  Met Asp Asn 
    1220                 1225                 1230             


Phe Asp  Tyr Leu Xaa Arg Asp  Trp Ser Ile Leu Gly  Pro His His 
    1235                 1240                 1245             


Leu Asp  Glu Phe Lys Arg Ile  Trp Ser Glu Tyr Asp  Pro Glu Ala 
    1250                 1255                 1260             


Lys Gly  Arg Ile Lys His Leu  Asp Val Val Xaa Leu  Leu Arg Arg 
    1265                 1270                 1275             


Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu Cys Pro  His Arg Val 
    1280                 1285                 1290             


Ala Cys  Lys Arg Leu Val Ala  Met Asn Met Pro Leu  Asn Ser Asp 
    1295                 1300                 1305             


Gly Xaa  Val Met Phe Asn Ala  Xaa Leu Phe Ala Leu  Val Arg Xaa 
    1310                 1315                 1320             


Ala Leu  Lys Ile Lys Xaa Glu  Gly Asn Leu Glu Gln  Ala Asn Glu 
    1325                 1330                 1335             


Glu Leu  Arg Ala Val Ile Lys  Lys Ile Trp Lys Lys  Xaa Ser Met 
    1340                 1345                 1350             


Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala Gly Gly  Gln Cys Ser 
    1355                 1360                 1365             


Leu Phe  Pro Lys 
    1370         


<210> 4690
<211> 453
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<400> 4690
Xaa Val Phe Xaa Gly Val Phe Xaa Val Glu Met Val Leu Lys Val Ile 
1               5                   10                  15      


Ala Phe Lys Pro Lys His Tyr Phe Xaa Asp Ala Trp Asn Xaa Phe Asp 
            20                  25                  30          


Ala Leu Ile Val Val Gly Ser Val Val Asp Ile Ala Ile Xaa Glu Val 
        35                  40                  45              


Asn Pro Xaa Glu Ser Glu Asn Val Pro Val Pro Xaa Ala Xaa Pro Gly 
    50                  55                  60                  


Asn Ser Glu Glu Ser Asn Arg Ile Ser Ile Xaa Phe Phe Arg Leu Phe 
65                  70                  75                  80  


Arg Val Met Arg Leu Val Lys Leu Leu Ser Arg Gly Glu Gly Ile Arg 
                85                  90                  95      


Xaa Leu Leu Trp Xaa Phe Ile Lys Ser Phe Gln Ala Leu Pro Tyr Val 
            100                 105                 110         


Ala Leu Leu Ile Ala Met Leu Phe Phe Ile Tyr Ala Val Ile Gly Met 
        115                 120                 125             


Gln Met Phe Gly Lys Val Ala Met Arg Asp Asn Asn Gln Ile Asn Arg 
    130                 135                 140                 


Asn Asn Asn Phe Gln Xaa Phe Pro Gln Ala Val Leu Leu Leu Phe Arg 
145                 150                 155                 160 


Cys Ala Xaa Gly Glu Ala Trp Gln Glu Ile Met Leu Ala Cys Leu Pro 
                165                 170                 175     


Gly Lys Leu Cys Asp Pro Glu Ser Asp Tyr Asn Pro Gly Glu Glu Tyr 
            180                 185                 190         


Xaa Cys Gly Ser Asn Phe Ala Ile Val Tyr Phe Ile Ser Phe Tyr Met 
        195                 200                 205             


Leu Cys Ala Phe Leu Ile Ile Asn Leu Phe Val Ala Val Ile Met Asp 
    210                 215                 220                 


Asn Phe Asp Tyr Leu Xaa Arg Asp Trp Ser Ile Leu Gly Pro His His 
225                 230                 235                 240 


Leu Asp Glu Phe Lys Arg Ile Trp Ser Glu Tyr Asp Pro Glu Ala Lys 
                245                 250                 255     


Gly Arg Ile Lys His Leu Asp Val Val Xaa Leu Leu Arg Arg Ile Gln 
            260                 265                 270         


Pro Pro Leu Gly Phe Gly Lys Leu Cys Pro His Arg Val Ala Cys Lys 
        275                 280                 285             


Arg Leu Val Ala Met Asn Met Pro Leu Asn Ser Asp Gly Xaa Val Met 
    290                 295                 300                 


Phe Asn Ala Xaa Leu Phe Ala Leu Val Arg Xaa Ala Leu Lys Ile Lys 
305                 310                 315                 320 


Xaa Glu Gly Asn Leu Glu Gln Ala Asn Glu Glu Leu Arg Ala Val Ile 
                325                 330                 335     


Lys Lys Ile Trp Lys Lys Xaa Ser Met Lys Leu Leu Asp Gln Val Val 
            340                 345                 350         


Pro Pro Ala Gly Asp Asp Glu Val Xaa Val Gly Lys Phe Tyr Ala Xaa 
        355                 360                 365             


Phe Leu Ile Gln Asp Tyr Phe Arg Lys Phe Lys Lys Arg Lys Glu Gln 
    370                 375                 380                 


Gly Leu Val Gly Lys Tyr Pro Ala Lys Asn Xaa Xaa Ile Ala Leu Gln 
385                 390                 395                 400 


Ala Gly Leu Arg Xaa Leu His Asp Ile Gly Pro Glu Ile Arg Arg Ala 
                405                 410                 415     


Ile Ser Cys Asp Leu Gln Asp Asp Glu Pro Glu Glu Xaa Lys Arg Glu 
            420                 425                 430         


Glu Glu Asp Asp Val Phe Lys Gln Glu Ile Arg Cys Val Ile Xaa Ile 
        435                 440                 445             


Ile Xaa Ile Ile Pro 
    450             


<210> 4691
<211> 116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<400> 4691
Asp Tyr Phe Arg Lys Phe Arg Arg Arg Lys Glu Lys Gly Leu Leu Gly 
1               5                   10                  15      


Asn Asp Ala Ala Pro Ser Xaa Ser Ser Ala Leu Gln Ala Gly Leu Arg 
            20                  25                  30          


Ser Leu Gln Asp Leu Gly Pro Glu Met Arg Gln Ala Leu Xaa Cys Asp 
        35                  40                  45              


Xaa Glu Glu Glu Glu Glu Glu Gly Gln Glu Gly Val Glu Glu Glu Asp 
    50                  55                  60                  


Glu Lys Asp Leu Glu Xaa Asn Lys Val Gly Xaa Ser Phe His Ser Pro 
65                  70                  75                  80  


Arg Asn Leu Ile Val Lys Tyr Phe Val Asn Pro Leu Ser Asp Phe Asp 
                85                  90                  95      


Xaa Ala Ser Gly Lys Lys Leu Pro Gln Arg Ser Pro Leu Cys Asn Arg 
            100                 105                 110         


Lys Ile Phe Ile 
        115     


<210> 4692
<211> 1966
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (996)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1017)..(1017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1128)..(1128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1193)..(1193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1240)..(1240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1245)..(1245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1282)..(1282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1304)..(1304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1308)..(1308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1347)..(1347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1357)..(1357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1400)..(1400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1437)..(1437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1509)..(1509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1511)..(1511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1515)..(1515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1522)..(1522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1528)..(1528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1575)..(1575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1602)..(1602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1625)..(1625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1628)..(1628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1649)..(1649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1653)..(1653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1691)..(1691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1693)..(1693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1706)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1717)..(1717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1729)..(1729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1784)..(1784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1793)..(1793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1811)..(1811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1829)..(1829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1863)..(1863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1865)..(1865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1872)..(1872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1921)..(1921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1937)..(1937)
<223> Selenocysteine

<400> 4692
Met Ser Glu Ser Glu Gly Gly Lys Asp Xaa Xaa Pro Glu Pro Ser Pro 
1               5                   10                  15      


Ala Asn Gly Ala Gly Pro Gly Pro Glu Trp Gly Leu Cys Pro Gly Pro 
            20                  25                  30          


Pro Ala Val Glu Gly Glu Ser Ser Gly Ala Ser Gly Leu Gly Xaa Pro 
        35                  40                  45              


Lys Arg Arg Asn Gln His Ser Lys His Lys Xaa Val Ala Val Ala Ser 
    50                  55                  60                  


Ala Gln Arg Ser Pro Arg Ala Leu Phe Cys Leu Xaa Leu Ala Asn Pro 
65                  70                  75                  80  


Leu Arg Arg Ser Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Asp Ile 
                85                  90                  95      


Leu Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Gly Val Tyr 
            100                 105                 110         


Ile Pro Phe Pro Glu Asp Asp Ser Asn Xaa Ala Asn His Asn Leu Glu 
        115                 120                 125             


Gln Val Glu Tyr Val Phe Leu Val Ile Phe Xaa Val Glu Xaa Val Leu 
    130                 135                 140                 


Lys Ile Val Ala Tyr Gly Leu Val Leu His Pro Ser Ala Tyr Ile Arg 
145                 150                 155                 160 


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
                165                 170                 175     


Ser Val Leu Leu Glu Gln Gly Pro Gly Arg Pro Gly Asp Ala Pro His 
            180                 185                 190         


Xaa Gly Gly Lys Pro Gly Gly Phe Asp Val Lys Ala Leu Arg Ala Phe 
        195                 200                 205             


Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu His 
    210                 215                 220                 


Ile Val Leu Asn Ser Ile Met Lys Ala Leu Val Pro Leu Leu His Ile 
225                 230                 235                 240 


Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu 
                245                 250                 255     


Glu Leu Phe Leu Gly Arg Met His Lys Xaa Cys Tyr Phe Leu Gly Ser 
            260                 265                 270         


Asp Met Glu Ala Glu Glu Asp Pro Ser Pro Cys Ala Ser Ser Gly Ser 
        275                 280                 285             


Gly Arg Ala Cys Xaa Leu Asn Gln Xaa Glu Cys Arg Gly Arg Trp Pro 
    290                 295                 300                 


Gly Pro Asn Gly Gly Ile Xaa Asn Phe Asp Asn Phe Phe Phe Ala Met 
305                 310                 315                 320 


Leu Xaa Val Phe Gln Cys Val Xaa Met Glu Gly Trp Xaa Asp Val Leu 
                325                 330                 335     


Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr Phe 
            340                 345                 350         


Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val Leu 
        355                 360                 365             


Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys Ala 
    370                 375                 380                 


Arg Gly Asp Phe Gln Lys Gln Arg Glu Lys Gln Gln Met Glu Glu Asp 
385                 390                 395                 400 


Leu Arg Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Glu Leu Asp Met 
                405                 410                 415     


Glu Asp Pro Ser Ala Asp Asp Asn Leu Gly Pro Gln Leu Ala Glu Leu 
            420                 425                 430         


Xaa Asn Arg Arg Arg Gly Arg Leu Arg Trp Phe Ser His Ser Xaa Arg 
        435                 440                 445             


Ser Xaa His Ser Xaa Ser Ser His Ala Ser Leu Pro Ala Ser Asp Xaa 
    450                 455                 460                 


Gly Ser Met Xaa Glu Xaa Gln Gly Asp Glu Asp Glu Glu Glu Gly Ala 
465                 470                 475                 480 


Leu Ala Ser Cys Xaa Arg Cys Leu Asn Lys Ile Met Lys Xaa Arg Val 
                485                 490                 495     


Cys Arg Arg Leu Arg Arg Ala Asn Arg Val Leu Arg Ala Arg Cys Arg 
            500                 505                 510         


Arg Ala Val Lys Ser Asn Ala Cys Tyr Trp Ala Val Leu Leu Leu Val 
        515                 520                 525             


Phe Leu Asn Xaa Leu Xaa Ile Ala Ser Glu His His Gly Gln Pro Val 
    530                 535                 540                 


Trp Leu Xaa Gln Ile Gln Glu Tyr Ala Asn Lys Val Leu Leu Cys Leu 
545                 550                 555                 560 


Phe Xaa Val Glu Met Leu Leu Lys Leu Tyr Gly Leu Gly Pro Ser Ala 
                565                 570                 575     


Tyr Val Ser Ser Phe Phe Asn Arg Phe Asp Cys Phe Val Val Cys Gly 
            580                 585                 590         


Gly Ile Leu Glu Xaa Xaa Leu Val Glu Val Gly Ala Met Gln Pro Leu 
        595                 600                 605             


Gly Ile Ser Val Leu Arg Cys Val Arg Leu Leu Arg Ile Phe Lys Val 
    610                 615                 620                 


Xaa Arg His Trp Ala Ser Leu Ser Asn Leu Val Ala Ser Leu Leu Asn 
625                 630                 635                 640 


Ser Met Lys Ser Ile Ala Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile 
                645                 650                 655     


Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe Gly Gly Lys Phe Asn 
            660                 665                 670         


Phe Asp Gln Xaa His Xaa Lys Arg Ser Xaa Phe Asp Xaa Phe Pro Gln 
        675                 680                 685             


Ala Leu Leu Xaa Val Phe Gln Ile Leu Xaa Gly Glu Asp Trp Asn Val 
    690                 695                 700                 


Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly Pro Phe Phe Pro Gly 
705                 710                 715                 720 


Met Leu Val Cys Ile Tyr Phe Ile Ile Leu Phe Ile Cys Gly Asn Tyr 
                725                 730                 735     


Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Ser 
            740                 745                 750         


Gly Asp Ala Gly Xaa Ala Lys Asp Lys Gly Gly Glu Lys Ser Asn Glu 
        755                 760                 765             


Lys Asp Leu Pro Gln Glu Asn Glu Gly Leu Val Pro Gly Val Glu Lys 
    770                 775                 780                 


Glu Glu Glu Glu Gly Ala Arg Arg Glu Gly Ala Asp Met Glu Glu Glu 
785                 790                 795                 800 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ala 
                805                 810                 815     


Gly Gly Val Glu Leu Leu Gln Glu Val Val Pro Lys Glu Lys Val Val 
            820                 825                 830         


Pro Ile Pro Glu Gly Ser Ala Phe Phe Cys Leu Ser Gln Xaa Asn Pro 
        835                 840                 845             


Leu Arg Lys Gly Cys His Xaa Leu Ile His His His Val Phe Xaa Asn 
    850                 855                 860                 


Leu Ile Leu Val Phe Ile Ile Leu Ser Ser Val Ser Leu Ala Ala Glu 
865                 870                 875                 880 


Asp Pro Ile Arg Ala His Ser Phe Arg Asn His Ile Leu Gly Tyr Phe 
                885                 890                 895     


Asp Tyr Ala Phe Xaa Ser Ile Phe Xaa Val Glu Ile Leu Leu Lys Met 
            900                 905                 910         


Xaa Val Phe Gly Ala Phe Leu His Arg Gly Ser Phe Cys Arg Ser Trp 
        915                 920                 925             


Phe Asn Met Leu Asp Leu Leu Val Val Ser Val Ser Leu Ile Ser Phe 
    930                 935                 940                 


Gly Ile His Ser Ser Ala Ile Ser Val Val Lys Ile Leu Arg Val Leu 
945                 950                 955                 960 


Arg Val Leu Arg Pro Leu Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys 
                965                 970                 975     


His Val Val Gln Cys Val Phe Val Ala Ile Arg Xaa Ile Gly Asn Ile 
            980                 985                 990         


Met Ile Val Xaa Xaa Leu Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val 
        995                 1000                 1005             


Gln Leu  Phe Lys Gly Lys Phe  Tyr Xaa Cys Xaa Asp  Glu Ala Lys 
    1010                 1015                 1020             


His Xaa  Pro Gln Glu Cys Lys  Gly Ser Phe Leu Val  Tyr Pro Asp 
    1025                 1030                 1035             


Gly Asp  Val Ser Arg Pro Leu  Val Arg Glu Arg Leu  Trp Val Asn 
    1040                 1045                 1050             


Ser Asp  Phe Asn Phe Asp Asn  Val Leu Ser Ala Met  Met Ala Leu 
    1055                 1060                 1065             


Phe Xaa  Val Ser Xaa Phe Glu  Gly Trp Pro Ala Leu  Leu Tyr Lys 
    1070                 1075                 1080             


Ala Ile  Asp Ala Tyr Ala Glu  Asp His Gly Pro Ile  Tyr Asn Tyr 
    1085                 1090                 1095             


Arg Val  Glu Ile Ser Val Phe  Phe Ile Val Tyr Ile  Ile Ile Ile 
    1100                 1105                 1110             


Ala Phe  Phe Met Met Asn Ile  Phe Val Gly Phe Val  Ile Ile Xaa 
    1115                 1120                 1125             


Phe Arg  Ala Gln Gly Glu Gln  Glu Tyr Gln Asn Cys  Glu Leu Asp 
    1130                 1135                 1140             


Lys Asn  Gln Arg Gln Cys Val  Glu Tyr Ala Leu Lys  Ala Gln Pro 
    1145                 1150                 1155             


Leu Arg  Arg Tyr Ile Pro Lys  Asn Pro His Gln Tyr  Arg Val Trp 
    1160                 1165                 1170             


Ala Xaa  Val Asn Ser Ala Ala  Phe Glu Tyr Leu Met  Phe Leu Leu 
    1175                 1180                 1185             


Ile Leu  Leu Asn Xaa Val Ala  Leu Ala Met Gln His  Tyr Glu Gln 
    1190                 1195                 1200             


Xaa Ala  Pro Phe Asn Tyr Ala  Met Asp Ile Leu Asn  Met Val Phe 
    1205                 1210                 1215             


Xaa Gly  Leu Phe Xaa Ile Glu  Met Val Leu Lys Ile  Ile Ala Phe 
    1220                 1225                 1230             


Lys Pro  Lys His Tyr Phe Xaa  Asp Ala Trp Asn Xaa  Phe Asp Ala 
    1235                 1240                 1245             


Leu Ile  Val Val Gly Ser Ile  Val Asp Ile Ala Val  Xaa Glu Val 
    1250                 1255                 1260             


Asn Asn  Gly Gly His Leu Gly  Glu Ser Ser Glu Asp  Ser Ser Arg 
    1265                 1270                 1275             


Ile Ser  Ile Xaa Phe Phe Arg  Leu Phe Arg Val Met  Arg Leu Val 
    1280                 1285                 1290             


Lys Leu  Leu Ser Lys Gly Glu  Gly Ile Arg Xaa Leu  Leu Trp Xaa 
    1295                 1300                 1305             


Phe Ile  Lys Ser Phe Gln Ala  Leu Pro Tyr Val Ala  Leu Leu Ile 
    1310                 1315                 1320             


Ala Met  Ile Phe Phe Ile Tyr  Ala Val Ile Gly Met  Gln Met Phe 
    1325                 1330                 1335             


Gly Lys  Val Ala Leu Gln Asp  Gly Xaa Gln Ile Asn  Arg Asn Asn 
    1340                 1345                 1350             


Asn Phe  Gln Xaa Phe Pro Gln  Ala Val Leu Leu Leu  Phe Arg Cys 
    1355                 1360                 1365             


Ala Xaa  Gly Glu Ala Trp Gln  Glu Ile Met Leu Ala  Ser Leu Pro 
    1370                 1375                 1380             


Gly Asn  Arg Cys Asp Pro Glu  Ser Asp Phe Gly Pro  Gly Glu Glu 
    1385                 1390                 1395             


Phe Xaa  Cys Gly Ser Asn Phe  Ala Ile Ala Tyr Phe  Ile Ser Phe 
    1400                 1405                 1410             


Phe Met  Leu Cys Ala Phe Leu  Ile Ile Asn Leu Phe  Val Ala Val 
    1415                 1420                 1425             


Ile Met  Asp Asn Phe Asp Tyr  Leu Xaa Arg Asp Trp  Ser Ile Leu 
    1430                 1435                 1440             


Gly Pro  His His Leu Asp Glu  Phe Lys Arg Ile Trp  Ser Glu Tyr 
    1445                 1450                 1455             


Asp Pro  Gly Ala Lys Gly Arg  Ile Lys His Leu Asp  Val Val Ala 
    1460                 1465                 1470             


Leu Leu  Arg Arg Ile Gln Pro  Pro Leu Gly Phe Gly  Lys Leu Cys 
    1475                 1480                 1485             


Pro His  Arg Val Ala Cys Lys  Arg Leu Val Ala Met  Asn Met Pro 
    1490                 1495                 1500             


Leu Asn  Ser Asp Gly Xaa Val  Xaa Phe Asn Ala Xaa  Leu Phe Ala 
    1505                 1510                 1515             


Leu Val  Arg Xaa Ser Leu Lys  Ile Lys Xaa Glu Gly  Asn Leu Glu 
    1520                 1525                 1530             


Gln Ala  Asn Gln Glu Leu Arg  Ile Val Ile Lys Lys  Ile Trp Lys 
    1535                 1540                 1545             


Arg Met  Lys Gln Lys Leu Leu  Asp Glu Val Ile Pro  Pro Pro Asp 
    1550                 1555                 1560             


Glu Glu  Glu Val Xaa Val Gly  Lys Phe Tyr Ala Xaa  Phe Leu Ile 
    1565                 1570                 1575             


Gln Asp  Tyr Phe Arg Lys Phe  Arg Arg Arg Lys Glu  Lys Gly Leu 
    1580                 1585                 1590             


Leu Gly  Asn Asp Ala Ala Pro  Ser Xaa Ser Ser Ala  Leu Gln Ala 
    1595                 1600                 1605             


Gly Leu  Arg Ser Leu Gln Asp  Leu Gly Pro Glu Met  Arg Gln Ala 
    1610                 1615                 1620             


Leu Xaa  Cys Asp Xaa Glu Glu  Glu Glu Glu Glu Gly  Gln Glu Gly 
    1625                 1630                 1635             


Val Glu  Glu Glu Asp Glu Lys  Asp Leu Glu Xaa Asn  Lys Ala Xaa 
    1640                 1645                 1650             


Met Val  Ser Gln Pro Ser Ala  Arg Arg Gly Ser Gly  Ile Ser Val 
    1655                 1660                 1665             


Ser Leu  Pro Val Gly Asp Arg  Leu Pro Asp Ser Leu  Ser Phe Gly 
    1670                 1675                 1680             


Pro Ser  Asp Asp Asp Arg Gly  Xaa Pro Xaa Ser Ser  Gln Pro Ser 
    1685                 1690                 1695             


Val Pro  Gln Ala Gly Ser Asn  Xaa His Arg Arg Gly  Ser Gly Ala 
    1700                 1705                 1710             


Leu Ile  Phe Xaa Ile Pro Glu  Glu Gly Asn Ser Gln  Pro Lys Gly 
    1715                 1720                 1725             


Xaa Lys  Gly Gln Asn Lys Gln  Asp Glu Asp Glu Glu  Val Pro Asp 
    1730                 1735                 1740             


Arg Leu  Ser Tyr Leu Asp Glu  Gln Ala Gly Xaa Pro  Pro Cys Ser 
    1745                 1750                 1755             


Val Leu  Leu Pro Pro His Arg  Ala Gln Arg Tyr Met  Asp Gly His 
    1760                 1765                 1770             


Leu Val  Pro Arg Arg Arg Leu  Leu Pro Pro Xaa Pro  Ala Gly Arg 
    1775                 1780                 1785             


Lys Pro  Ser Phe Xaa Ile Gln  Cys Leu Gln Arg Gln  Gly Ser Cys 
    1790                 1795                 1800             


Glu Asp  Leu Pro Ile Pro Gly  Xaa Tyr His Arg Gly  Arg Asn Ser 
    1805                 1810                 1815             


Gly Pro  Asn Arg Ala Gln Gly  Ser Trp Ala Xaa Pro  Pro Gln Arg 
    1820                 1825                 1830             


Gly Arg  Leu Leu Tyr Ala Pro  Leu Leu Leu Val Glu  Glu Gly Ala 
    1835                 1840                 1845             


Ala Gly  Glu Gly Tyr Leu Gly  Arg Ser Ser Gly Pro  Leu Arg Xaa 
    1850                 1855                 1860             


Phe Xaa  Cys Leu His Val Pro  Gly Xaa His Ser Asp  Pro Ser His 
    1865                 1870                 1875             


Gly Lys  Arg Gly Ser Ala Asp  Ser Leu Val Glu Ala  Val Leu Ile 
    1880                 1885                 1890             


Ser Glu  Gly Leu Gly Leu Phe  Ala Arg Asp Pro Arg  Phe Val Ala 
    1895                 1900                 1905             


Leu Ala  Lys Gln Glu Ile Ala  Asp Ala Cys Arg Leu  Xaa Leu Asp 
    1910                 1915                 1920             


Glu Met  Asp Asn Ala Ala Ser  Asp Leu Leu Ala Gln  Gly Xaa Ser 
    1925                 1930                 1935             


Ser Leu  Tyr Ser Asp Glu Glu  Ser Ile Leu Ser Arg  Phe Asp Glu 
    1940                 1945                 1950             


Glu Asp  Leu Gly Asp Glu Met  Ala Cys Val His Ala  Leu 
    1955                 1960                 1965     


<210> 4693
<211> 1977
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1007)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1234)..(1234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1272)..(1272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1293)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1315)..(1315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1319)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1368)..(1368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1411)..(1411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1448)..(1448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1520)..(1520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1522)..(1522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1526)..(1526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1533)..(1533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1539)..(1539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1579)..(1579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1613)..(1613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1636)..(1636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1639)..(1639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1660)..(1660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1664)..(1664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1702)..(1702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1704)..(1704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1717)..(1717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1728)..(1728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1765)..(1765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1795)..(1795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1804)..(1804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1822)..(1822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1840)..(1840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1874)..(1874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1876)..(1876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1883)..(1883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1932)..(1932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1948)..(1948)
<223> Selenocysteine

<400> 4693
Met Ser Glu Ser Glu Gly Gly Lys Asp Xaa Xaa Pro Glu Pro Ser Pro 
1               5                   10                  15      


Ala Asn Gly Ala Gly Pro Gly Pro Glu Trp Gly Leu Cys Pro Gly Pro 
            20                  25                  30          


Pro Ala Val Glu Gly Glu Ser Ser Gly Ala Ser Gly Leu Gly Xaa Pro 
        35                  40                  45              


Lys Arg Arg Asn Gln His Ser Lys His Lys Xaa Val Ala Val Ala Ser 
    50                  55                  60                  


Ala Gln Arg Ser Pro Arg Ala Leu Phe Cys Leu Xaa Leu Ala Asn Pro 
65                  70                  75                  80  


Leu Arg Arg Ser Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Asp Ile 
                85                  90                  95      


Leu Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Gly Val Tyr 
            100                 105                 110         


Ile Pro Phe Pro Glu Asp Asp Ser Asn Xaa Ala Asn His Asn Leu Glu 
        115                 120                 125             


Gln Val Glu Tyr Val Phe Leu Val Ile Phe Xaa Val Glu Xaa Val Leu 
    130                 135                 140                 


Lys Ile Val Ala Tyr Gly Leu Val Leu His Pro Ser Ala Tyr Ile Arg 
145                 150                 155                 160 


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
                165                 170                 175     


Ser Val Leu Leu Glu Gln Gly Pro Gly Arg Pro Gly Asp Ala Pro His 
            180                 185                 190         


Xaa Gly Gly Lys Pro Gly Gly Phe Asp Val Lys Ala Leu Arg Ala Phe 
        195                 200                 205             


Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu His 
    210                 215                 220                 


Ile Val Leu Asn Ser Ile Met Lys Ala Leu Val Pro Leu Leu His Ile 
225                 230                 235                 240 


Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu 
                245                 250                 255     


Glu Leu Phe Leu Gly Arg Met His Lys Xaa Cys Tyr Phe Leu Gly Ser 
            260                 265                 270         


Asp Met Glu Ala Glu Glu Asp Pro Ser Pro Cys Ala Ser Ser Gly Ser 
        275                 280                 285             


Gly Arg Ala Cys Xaa Leu Asn Gln Xaa Glu Cys Arg Gly Arg Trp Pro 
    290                 295                 300                 


Gly Pro Asn Gly Gly Ile Xaa Asn Phe Asp Asn Phe Phe Phe Ala Met 
305                 310                 315                 320 


Leu Xaa Val Phe Gln Cys Val Xaa Met Glu Gly Trp Xaa Asp Val Leu 
                325                 330                 335     


Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr Phe 
            340                 345                 350         


Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val Leu 
        355                 360                 365             


Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys Ala 
    370                 375                 380                 


Arg Gly Asp Phe Gln Lys Gln Arg Glu Lys Gln Gln Met Glu Glu Asp 
385                 390                 395                 400 


Leu Arg Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Glu Leu Asp Met 
                405                 410                 415     


Glu Asp Pro Ser Ala Asp Asp Asn Leu Gly Ser Met Ala Glu Glu Gly 
            420                 425                 430         


Arg Ala Gly His Arg Pro Gln Leu Ala Glu Leu Xaa Asn Arg Arg Arg 
        435                 440                 445             


Gly Arg Leu Arg Trp Phe Ser His Ser Xaa Arg Ser Xaa His Ser Xaa 
    450                 455                 460                 


Ser Ser His Ala Ser Leu Pro Ala Ser Asp Xaa Gly Ser Met Xaa Glu 
465                 470                 475                 480 


Xaa Gln Gly Asp Glu Asp Glu Glu Glu Gly Ala Leu Ala Ser Cys Xaa 
                485                 490                 495     


Arg Cys Leu Asn Lys Ile Met Lys Xaa Arg Val Cys Arg Arg Leu Arg 
            500                 505                 510         


Arg Ala Asn Arg Val Leu Arg Ala Arg Cys Arg Arg Ala Val Lys Ser 
        515                 520                 525             


Asn Ala Cys Tyr Trp Ala Val Leu Leu Leu Val Phe Leu Asn Xaa Leu 
    530                 535                 540                 


Xaa Ile Ala Ser Glu His His Gly Gln Pro Val Trp Leu Xaa Gln Ile 
545                 550                 555                 560 


Gln Glu Tyr Ala Asn Lys Val Leu Leu Cys Leu Phe Xaa Val Glu Met 
                565                 570                 575     


Leu Leu Lys Leu Tyr Gly Leu Gly Pro Ser Ala Tyr Val Ser Ser Phe 
            580                 585                 590         


Phe Asn Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa 
        595                 600                 605             


Xaa Leu Val Glu Val Gly Ala Met Gln Pro Leu Gly Ile Ser Val Leu 
    610                 615                 620                 


Arg Cys Val Arg Leu Leu Arg Ile Phe Lys Val Xaa Arg His Trp Ala 
625                 630                 635                 640 


Ser Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Met Lys Ser Ile 
                645                 650                 655     


Ala Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu 
            660                 665                 670         


Leu Gly Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Gln Xaa His 
        675                 680                 685             


Xaa Lys Arg Ser Xaa Phe Asp Xaa Phe Pro Gln Ala Leu Leu Xaa Val 
    690                 695                 700                 


Phe Gln Ile Leu Xaa Gly Glu Asp Trp Asn Val Val Met Tyr Asp Gly 
705                 710                 715                 720 


Ile Met Ala Tyr Gly Gly Pro Phe Phe Pro Gly Met Leu Val Cys Ile 
                725                 730                 735     


Tyr Phe Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val 
            740                 745                 750         


Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Ser Gly Asp Ala Gly Xaa 
        755                 760                 765             


Ala Lys Asp Lys Gly Gly Glu Lys Ser Asn Glu Lys Asp Leu Pro Gln 
    770                 775                 780                 


Glu Asn Glu Gly Leu Val Pro Gly Val Glu Lys Glu Glu Glu Glu Gly 
785                 790                 795                 800 


Ala Arg Arg Glu Gly Ala Asp Met Glu Glu Glu Glu Glu Glu Glu Glu 
                805                 810                 815     


Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ala Gly Gly Val Glu Leu 
            820                 825                 830         


Leu Gln Glu Val Val Pro Lys Glu Lys Val Val Pro Ile Pro Glu Gly 
        835                 840                 845             


Ser Ala Phe Phe Cys Leu Ser Gln Xaa Asn Pro Leu Arg Lys Gly Cys 
    850                 855                 860                 


His Xaa Leu Ile His His His Val Phe Xaa Asn Leu Ile Leu Val Phe 
865                 870                 875                 880 


Ile Ile Leu Ser Ser Val Ser Leu Ala Ala Glu Asp Pro Ile Arg Ala 
                885                 890                 895     


His Ser Phe Arg Asn His Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Xaa 
            900                 905                 910         


Ser Ile Phe Xaa Val Glu Ile Leu Leu Lys Met Xaa Val Phe Gly Ala 
        915                 920                 925             


Phe Leu His Arg Gly Ser Phe Cys Arg Ser Trp Phe Asn Met Leu Asp 
    930                 935                 940                 


Leu Leu Val Val Ser Val Ser Leu Ile Ser Phe Gly Ile His Ser Ser 
945                 950                 955                 960 


Ala Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro 
                965                 970                 975     


Leu Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys His Val Val Gln Cys 
            980                 985                 990         


Val Phe Val Ala Ile Arg Xaa Ile  Gly Asn Ile Met Ile  Val Xaa Xaa 
        995                 1000                 1005             


Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly Val Gln  Leu Phe Lys 
    1010                 1015                 1020             


Gly Lys  Phe Tyr Xaa Cys Xaa  Asp Glu Ala Lys His  Xaa Pro Gln 
    1025                 1030                 1035             


Glu Cys  Lys Gly Ser Phe Leu  Val Tyr Pro Asp Gly  Asp Val Ser 
    1040                 1045                 1050             


Arg Pro  Leu Val Arg Glu Arg  Leu Trp Val Asn Ser  Asp Phe Asn 
    1055                 1060                 1065             


Phe Asp  Asn Val Leu Ser Ala  Met Met Ala Leu Phe  Xaa Val Ser 
    1070                 1075                 1080             


Xaa Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr Lys Ala  Ile Asp Ala 
    1085                 1090                 1095             


Tyr Ala  Glu Asp His Gly Pro  Ile Tyr Asn Tyr Arg  Val Glu Ile 
    1100                 1105                 1110             


Ser Val  Phe Phe Ile Val Tyr  Ile Ile Ile Ile Ala  Phe Phe Met 
    1115                 1120                 1125             


Met Asn  Ile Phe Val Gly Phe  Val Ile Ile Xaa Phe  Arg Ala Gln 
    1130                 1135                 1140             


Gly Glu  Gln Glu Tyr Gln Asn  Cys Glu Leu Asp Lys  Asn Gln Arg 
    1145                 1150                 1155             


Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Gln Pro Leu  Arg Arg Tyr 
    1160                 1165                 1170             


Ile Pro  Lys Asn Pro His Gln  Tyr Arg Val Trp Ala  Xaa Val Asn 
    1175                 1180                 1185             


Ser Ala  Ala Phe Glu Tyr Leu  Met Phe Leu Leu Ile  Leu Leu Asn 
    1190                 1195                 1200             


Xaa Val  Ala Leu Ala Met Gln  His Tyr Glu Gln Xaa  Ala Pro Phe 
    1205                 1210                 1215             


Asn Tyr  Ala Met Asp Ile Leu  Asn Met Val Phe Xaa  Gly Leu Phe 
    1220                 1225                 1230             


Xaa Ile  Glu Met Val Leu Lys  Ile Ile Ala Phe Lys  Pro Lys His 
    1235                 1240                 1245             


Tyr Phe  Xaa Asp Ala Trp Asn  Xaa Phe Asp Ala Leu  Ile Val Val 
    1250                 1255                 1260             


Gly Ser  Ile Val Asp Ile Ala  Val Xaa Glu Val Asn  Asn Gly Gly 
    1265                 1270                 1275             


His Leu  Gly Glu Ser Ser Glu  Asp Ser Ser Arg Ile  Ser Ile Xaa 
    1280                 1285                 1290             


Phe Phe  Arg Leu Phe Arg Val  Met Arg Leu Val Lys  Leu Leu Ser 
    1295                 1300                 1305             


Lys Gly  Glu Gly Ile Arg Xaa  Leu Leu Trp Xaa Phe  Ile Lys Ser 
    1310                 1315                 1320             


Phe Gln  Ala Leu Pro Tyr Val  Ala Leu Leu Ile Ala  Met Ile Phe 
    1325                 1330                 1335             


Phe Ile  Tyr Ala Val Ile Gly  Met Gln Met Phe Gly  Lys Val Ala 
    1340                 1345                 1350             


Leu Gln  Asp Gly Xaa Gln Ile  Asn Arg Asn Asn Asn  Phe Gln Xaa 
    1355                 1360                 1365             


Phe Pro  Gln Ala Val Leu Leu  Leu Phe Arg Cys Ala  Xaa Gly Glu 
    1370                 1375                 1380             


Ala Trp  Gln Glu Ile Met Leu  Ala Ser Leu Pro Gly  Asn Arg Cys 
    1385                 1390                 1395             


Asp Pro  Glu Ser Asp Phe Gly  Pro Gly Glu Glu Phe  Xaa Cys Gly 
    1400                 1405                 1410             


Ser Asn  Phe Ala Ile Ala Tyr  Phe Ile Ser Phe Phe  Met Leu Cys 
    1415                 1420                 1425             


Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala Val Ile  Met Asp Asn 
    1430                 1435                 1440             


Phe Asp  Tyr Leu Xaa Arg Asp  Trp Ser Ile Leu Gly  Pro His His 
    1445                 1450                 1455             


Leu Asp  Glu Phe Lys Arg Ile  Trp Ser Glu Tyr Asp  Pro Gly Ala 
    1460                 1465                 1470             


Lys Gly  Arg Ile Lys His Leu  Asp Val Val Ala Leu  Leu Arg Arg 
    1475                 1480                 1485             


Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu Cys Pro  His Arg Val 
    1490                 1495                 1500             


Ala Cys  Lys Arg Leu Val Ala  Met Asn Met Pro Leu  Asn Ser Asp 
    1505                 1510                 1515             


Gly Xaa  Val Xaa Phe Asn Ala  Xaa Leu Phe Ala Leu  Val Arg Xaa 
    1520                 1525                 1530             


Ser Leu  Lys Ile Lys Xaa Glu  Gly Asn Leu Glu Gln  Ala Asn Gln 
    1535                 1540                 1545             


Glu Leu  Arg Ile Val Ile Lys  Lys Ile Trp Lys Arg  Met Lys Gln 
    1550                 1555                 1560             


Lys Leu  Leu Asp Glu Val Ile  Pro Pro Pro Asp Glu  Glu Glu Val 
    1565                 1570                 1575             


Xaa Val  Gly Lys Phe Tyr Ala  Xaa Phe Leu Ile Gln  Asp Tyr Phe 
    1580                 1585                 1590             


Arg Lys  Phe Arg Arg Arg Lys  Glu Lys Gly Leu Leu  Gly Asn Asp 
    1595                 1600                 1605             


Ala Ala  Pro Ser Xaa Ser Ser  Ala Leu Gln Ala Gly  Leu Arg Ser 
    1610                 1615                 1620             


Leu Gln  Asp Leu Gly Pro Glu  Met Arg Gln Ala Leu  Xaa Cys Asp 
    1625                 1630                 1635             


Xaa Glu  Glu Glu Glu Glu Glu  Gly Gln Glu Gly Val  Glu Glu Glu 
    1640                 1645                 1650             


Asp Glu  Lys Asp Leu Glu Xaa  Asn Lys Ala Xaa Met  Val Ser Gln 
    1655                 1660                 1665             


Pro Ser  Ala Arg Arg Gly Ser  Gly Ile Ser Val Ser  Leu Pro Val 
    1670                 1675                 1680             


Gly Asp  Arg Leu Pro Asp Ser  Leu Ser Phe Gly Pro  Ser Asp Asp 
    1685                 1690                 1695             


Asp Arg  Gly Xaa Pro Xaa Ser  Ser Gln Pro Ser Val  Pro Gln Ala 
    1700                 1705                 1710             


Gly Ser  Asn Xaa His Arg Arg  Gly Ser Gly Ala Leu  Ile Phe Xaa 
    1715                 1720                 1725             


Ile Pro  Glu Glu Gly Asn Ser  Gln Pro Lys Gly Xaa  Lys Gly Gln 
    1730                 1735                 1740             


Asn Lys  Gln Asp Glu Asp Glu  Glu Val Pro Asp Arg  Leu Ser Tyr 
    1745                 1750                 1755             


Leu Asp  Glu Gln Ala Gly Xaa  Pro Pro Cys Ser Val  Leu Leu Pro 
    1760                 1765                 1770             


Pro His  Arg Ala Gln Arg Tyr  Met Asp Gly His Leu  Val Pro Arg 
    1775                 1780                 1785             


Arg Arg  Leu Leu Pro Pro Xaa  Pro Ala Gly Arg Lys  Pro Ser Phe 
    1790                 1795                 1800             


Xaa Ile  Gln Cys Leu Gln Arg  Gln Gly Ser Cys Glu  Asp Leu Pro 
    1805                 1810                 1815             


Ile Pro  Gly Xaa Tyr His Arg  Gly Arg Asn Ser Gly  Pro Asn Arg 
    1820                 1825                 1830             


Ala Gln  Gly Ser Trp Ala Xaa  Pro Pro Gln Arg Gly  Arg Leu Leu 
    1835                 1840                 1845             


Tyr Ala  Pro Leu Leu Leu Val  Glu Glu Gly Ala Ala  Gly Glu Gly 
    1850                 1855                 1860             


Tyr Leu  Gly Arg Ser Ser Gly  Pro Leu Arg Xaa Phe  Xaa Cys Leu 
    1865                 1870                 1875             


His Val  Pro Gly Xaa His Ser  Asp Pro Ser His Gly  Lys Arg Gly 
    1880                 1885                 1890             


Ser Ala  Asp Ser Leu Val Glu  Ala Val Leu Ile Ser  Glu Gly Leu 
    1895                 1900                 1905             


Gly Leu  Phe Ala Arg Asp Pro  Arg Phe Val Ala Leu  Ala Lys Gln 
    1910                 1915                 1920             


Glu Ile  Ala Asp Ala Cys Arg  Leu Xaa Leu Asp Glu  Met Asp Asn 
    1925                 1930                 1935             


Ala Ala  Ser Asp Leu Leu Ala  Gln Gly Xaa Ser Ser  Leu Tyr Ser 
    1940                 1945                 1950             


Asp Glu  Glu Ser Ile Leu Ser  Arg Phe Asp Glu Glu  Asp Leu Gly 
    1955                 1960                 1965             


Asp Glu  Met Ala Cys Val His  Ala Leu 
    1970                 1975         


<210> 4694
<211> 1912
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1191)..(1191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1293)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1316)..(1316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1346)..(1346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1383)..(1383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1461)..(1461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1474)..(1474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1514)..(1514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1521)..(1521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1548)..(1548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1571)..(1571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1595)..(1595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1599)..(1599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1637)..(1637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1639)..(1639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1652)..(1652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1663)..(1663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1675)..(1675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1700)..(1700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1730)..(1730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1739)..(1739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1757)..(1757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1775)..(1775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1809)..(1809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1811)..(1811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1818)..(1818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1867)..(1867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1883)..(1883)
<223> Selenocysteine

<400> 4694
Met Ser Glu Ser Glu Gly Gly Lys Gly Glu Arg Ile Leu Pro Ser Leu 
1               5                   10                  15      


Gln Xaa Leu Gly Ala Ser Ile Val Glu Trp Lys Pro Phe Asp Ile Leu 
            20                  25                  30          


Ile Leu Leu Xaa Ile Phe Ala Asn Cys Val Ala Leu Gly Val Tyr Ile 
        35                  40                  45              


Pro Phe Pro Glu Asp Asp Ser Asn Xaa Ala Asn His Asn Leu Glu Gln 
    50                  55                  60                  


Val Glu Tyr Val Phe Leu Val Ile Phe Xaa Val Glu Xaa Val Leu Lys 
65                  70                  75                  80  


Ile Val Ala Tyr Gly Leu Val Leu His Pro Ser Ala Tyr Ile Arg Asn 
                85                  90                  95      


Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe Ser 
            100                 105                 110         


Val Leu Leu Glu Gln Gly Pro Gly Arg Pro Gly Asp Ala Pro His Xaa 
        115                 120                 125             


Gly Gly Lys Pro Gly Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
    130                 135                 140                 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu His Ile 
145                 150                 155                 160 


Val Leu Asn Ser Ile Met Lys Ala Leu Val Pro Leu Leu His Ile Ala 
                165                 170                 175     


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
            180                 185                 190         


Leu Phe Leu Gly Arg Met His Lys Xaa Cys Tyr Phe Leu Gly Ser Asp 
        195                 200                 205             


Met Glu Ala Glu Glu Asp Pro Ser Pro Cys Ala Ser Ser Gly Ser Gly 
    210                 215                 220                 


Arg Ala Cys Xaa Leu Asn Gln Xaa Glu Cys Arg Gly Arg Trp Pro Gly 
225                 230                 235                 240 


Pro Asn Gly Gly Ile Xaa Asn Phe Asp Asn Phe Phe Phe Ala Met Leu 
                245                 250                 255     


Xaa Val Phe Gln Cys Val Xaa Met Glu Gly Trp Xaa Asp Val Leu Tyr 
            260                 265                 270         


Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr Phe Val 
        275                 280                 285             


Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val Leu Gly 
    290                 295                 300                 


Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys Ala Arg 
305                 310                 315                 320 


Gly Asp Phe Gln Lys Gln Arg Glu Lys Gln Gln Met Glu Glu Asp Leu 
                325                 330                 335     


Arg Gly Tyr Leu Asp Trp Ile Xaa Gln Ala Glu Glu Leu Asp Met Glu 
            340                 345                 350         


Asp Pro Ser Ala Asp Asp Asn Leu Gly Ser Met Ala Glu Glu Gly Arg 
        355                 360                 365             


Ala Gly His Arg Pro Gln Leu Ala Glu Leu Xaa Asn Arg Arg Arg Gly 
    370                 375                 380                 


Arg Leu Arg Trp Phe Ser His Ser Xaa Arg Ser Xaa His Ser Xaa Ser 
385                 390                 395                 400 


Ser His Ala Ser Leu Pro Ala Ser Asp Xaa Gly Ser Met Xaa Glu Xaa 
                405                 410                 415     


Gln Gly Asp Glu Asp Glu Glu Glu Gly Ala Leu Ala Ser Cys Xaa Arg 
            420                 425                 430         


Cys Leu Asn Lys Ile Met Lys Xaa Arg Val Cys Arg Arg Leu Arg Arg 
        435                 440                 445             


Ala Asn Arg Val Leu Arg Ala Arg Cys Arg Arg Ala Val Lys Ser Asn 
    450                 455                 460                 


Ala Cys Tyr Trp Ala Val Leu Leu Leu Val Phe Leu Asn Xaa Leu Xaa 
465                 470                 475                 480 


Ile Ala Ser Glu His His Gly Gln Pro Val Trp Leu Xaa Gln Ile Gln 
                485                 490                 495     


Glu Tyr Ala Asn Lys Val Leu Leu Cys Leu Phe Xaa Val Glu Met Leu 
            500                 505                 510         


Leu Lys Leu Tyr Gly Leu Gly Pro Ser Ala Tyr Val Ser Ser Phe Phe 
        515                 520                 525             


Asn Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Leu Glu Xaa Xaa 
    530                 535                 540                 


Leu Val Glu Val Gly Ala Met Gln Pro Leu Gly Ile Ser Val Leu Arg 
545                 550                 555                 560 


Cys Val Arg Leu Leu Arg Ile Phe Lys Val Xaa Arg His Trp Ala Ser 
                565                 570                 575     


Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Met Lys Ser Ile Ala 
            580                 585                 590         


Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu 
        595                 600                 605             


Gly Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Gln Xaa His Xaa 
    610                 615                 620                 


Lys Arg Ser Xaa Phe Asp Xaa Phe Pro Gln Ala Leu Leu Xaa Val Phe 
625                 630                 635                 640 


Gln Ile Leu Xaa Gly Glu Asp Trp Asn Val Val Met Tyr Asp Gly Ile 
                645                 650                 655     


Met Ala Tyr Gly Gly Pro Phe Phe Pro Gly Met Leu Val Cys Ile Tyr 
            660                 665                 670         


Phe Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe 
        675                 680                 685             


Leu Ala Ile Ala Val Asp Asn Leu Ala Ser Gly Asp Ala Gly Xaa Ala 
    690                 695                 700                 


Lys Asp Lys Gly Gly Glu Lys Ser Asn Glu Lys Asp Leu Pro Gln Glu 
705                 710                 715                 720 


Asn Glu Gly Leu Val Pro Gly Val Glu Lys Glu Glu Glu Glu Gly Ala 
                725                 730                 735     


Arg Arg Glu Gly Ala Asp Met Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            740                 745                 750         


Glu Glu Glu Glu Glu Glu Glu Glu Gly Ala Gly Gly Val Glu Leu Leu 
        755                 760                 765             


Gln Glu Val Val Pro Lys Glu Lys Val Val Pro Ile Pro Glu Gly Ser 
    770                 775                 780                 


Ala Phe Phe Cys Leu Ser Gln Xaa Asn Pro Leu Arg Lys Gly Cys His 
785                 790                 795                 800 


Xaa Leu Ile His His His Val Phe Xaa Asn Leu Ile Leu Val Phe Ile 
                805                 810                 815     


Ile Leu Ser Ser Val Ser Leu Ala Ala Glu Asp Pro Ile Arg Ala His 
            820                 825                 830         


Ser Phe Arg Asn His Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Xaa Ser 
        835                 840                 845             


Ile Phe Xaa Val Glu Ile Leu Leu Lys Met Xaa Val Phe Gly Ala Phe 
    850                 855                 860                 


Leu His Arg Gly Ser Phe Cys Arg Ser Trp Phe Asn Met Leu Asp Leu 
865                 870                 875                 880 


Leu Val Val Ser Val Ser Leu Ile Ser Phe Gly Ile His Ser Ser Ala 
                885                 890                 895     


Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu 
            900                 905                 910         


Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys His Val Val Gln Cys Val 
        915                 920                 925             


Phe Val Ala Ile Arg Xaa Ile Gly Asn Ile Met Ile Val Xaa Xaa Leu 
    930                 935                 940                 


Leu Gln Phe Met Phe Ala Cys Ile Gly Val Gln Leu Phe Lys Gly Lys 
945                 950                 955                 960 


Phe Tyr Xaa Cys Xaa Asp Glu Ala Lys His Xaa Pro Gln Glu Cys Lys 
                965                 970                 975     


Gly Ser Phe Leu Val Tyr Pro Asp Gly Asp Val Ser Arg Pro Leu Val 
            980                 985                 990         


Arg Glu Arg Leu Trp Val Asn Ser  Asp Phe Asn Phe Asp  Asn Val Leu 
        995                 1000                 1005             


Ser Ala  Met Met Ala Leu Phe  Xaa Val Ser Xaa Phe  Glu Gly Trp 
    1010                 1015                 1020             


Pro Ala  Leu Leu Tyr Lys Ala  Ile Asp Ala Tyr Ala  Glu Asp His 
    1025                 1030                 1035             


Gly Pro  Ile Tyr Asn Tyr Arg  Val Glu Ile Ser Val  Phe Phe Ile 
    1040                 1045                 1050             


Val Tyr  Ile Ile Ile Ile Ala  Phe Phe Met Met Asn  Ile Phe Val 
    1055                 1060                 1065             


Gly Phe  Val Ile Ile Xaa Phe  Arg Ala Gln Gly Glu  Gln Glu Tyr 
    1070                 1075                 1080             


Gln Asn  Cys Glu Leu Asp Lys  Asn Gln Arg Gln Cys  Val Glu Tyr 
    1085                 1090                 1095             


Ala Leu  Lys Ala Gln Pro Leu  Arg Arg Tyr Ile Pro  Lys Asn Pro 
    1100                 1105                 1110             


His Gln  Tyr Arg Val Trp Ala  Xaa Val Asn Ser Ala  Ala Phe Glu 
    1115                 1120                 1125             


Tyr Leu  Met Phe Leu Leu Ile  Leu Leu Asn Xaa Val  Ala Leu Ala 
    1130                 1135                 1140             


Met Gln  His Tyr Glu Gln Xaa  Ala Pro Phe Asn Tyr  Ala Met Asp 
    1145                 1150                 1155             


Ile Leu  Asn Met Val Phe Xaa  Gly Leu Phe Xaa Ile  Glu Met Val 
    1160                 1165                 1170             


Leu Lys  Ile Ile Ala Phe Lys  Pro Lys His Tyr Phe  Xaa Asp Ala 
    1175                 1180                 1185             


Trp Asn  Xaa Phe Asp Ala Leu  Ile Val Val Gly Ser  Ile Val Asp 
    1190                 1195                 1200             


Ile Ala  Val Xaa Glu Val Asn  Asn Gly Gly His Leu  Gly Glu Ser 
    1205                 1210                 1215             


Ser Glu  Asp Ser Ser Arg Ile  Ser Ile Xaa Phe Phe  Arg Leu Phe 
    1220                 1225                 1230             


Arg Val  Met Arg Leu Val Lys  Leu Leu Ser Lys Gly  Glu Gly Ile 
    1235                 1240                 1245             


Arg Xaa  Leu Leu Trp Xaa Phe  Ile Lys Ser Phe Gln  Ala Leu Pro 
    1250                 1255                 1260             


Tyr Val  Ala Leu Leu Ile Ala  Met Ile Phe Phe Ile  Tyr Ala Val 
    1265                 1270                 1275             


Ile Gly  Met Gln Met Phe Gly  Lys Val Ala Leu Gln  Asp Gly Xaa 
    1280                 1285                 1290             


Gln Ile  Asn Arg Asn Asn Asn  Phe Gln Xaa Phe Pro  Gln Ala Val 
    1295                 1300                 1305             


Leu Leu  Leu Phe Arg Cys Ala  Xaa Gly Glu Ala Trp  Gln Glu Ile 
    1310                 1315                 1320             


Met Leu  Ala Ser Leu Pro Gly  Asn Arg Cys Asp Pro  Glu Ser Asp 
    1325                 1330                 1335             


Phe Gly  Pro Gly Glu Glu Phe  Xaa Cys Gly Ser Asn  Phe Ala Ile 
    1340                 1345                 1350             


Ala Tyr  Phe Ile Ser Phe Phe  Met Leu Cys Ala Phe  Leu Ile Ile 
    1355                 1360                 1365             


Asn Leu  Phe Val Ala Val Ile  Met Asp Asn Phe Asp  Tyr Leu Xaa 
    1370                 1375                 1380             


Arg Asp  Trp Ser Ile Leu Gly  Pro His His Leu Asp  Glu Phe Lys 
    1385                 1390                 1395             


Arg Ile  Trp Ser Glu Tyr Asp  Pro Gly Ala Lys Gly  Arg Ile Lys 
    1400                 1405                 1410             


His Leu  Asp Val Val Ala Leu  Leu Arg Arg Ile Gln  Pro Pro Leu 
    1415                 1420                 1425             


Gly Phe  Gly Lys Leu Cys Pro  His Arg Val Ala Cys  Lys Arg Leu 
    1430                 1435                 1440             


Val Ala  Met Asn Met Pro Leu  Asn Ser Asp Gly Xaa  Val Xaa Phe 
    1445                 1450                 1455             


Asn Ala  Xaa Leu Phe Ala Leu  Val Arg Xaa Ser Leu  Lys Ile Lys 
    1460                 1465                 1470             


Xaa Glu  Gly Asn Leu Glu Gln  Ala Asn Gln Glu Leu  Arg Ile Val 
    1475                 1480                 1485             


Ile Lys  Lys Ile Trp Lys Arg  Met Lys Gln Lys Leu  Leu Asp Glu 
    1490                 1495                 1500             


Val Ile  Pro Pro Pro Asp Glu  Glu Glu Val Xaa Val  Gly Lys Phe 
    1505                 1510                 1515             


Tyr Ala  Xaa Phe Leu Ile Gln  Asp Tyr Phe Arg Lys  Phe Arg Arg 
    1520                 1525                 1530             


Arg Lys  Glu Lys Gly Leu Leu  Gly Asn Asp Ala Ala  Pro Ser Xaa 
    1535                 1540                 1545             


Ser Ser  Ala Leu Gln Ala Gly  Leu Arg Ser Leu Gln  Asp Leu Gly 
    1550                 1555                 1560             


Pro Glu  Met Arg Gln Ala Leu  Xaa Cys Asp Xaa Glu  Glu Glu Glu 
    1565                 1570                 1575             


Glu Glu  Gly Gln Glu Gly Val  Glu Glu Glu Asp Glu  Lys Asp Leu 
    1580                 1585                 1590             


Glu Xaa  Asn Lys Ala Xaa Met  Val Ser Gln Pro Ser  Ala Arg Arg 
    1595                 1600                 1605             


Gly Ser  Gly Ile Ser Val Ser  Leu Pro Val Gly Asp  Arg Leu Pro 
    1610                 1615                 1620             


Asp Ser  Leu Ser Phe Gly Pro  Ser Asp Asp Asp Arg  Gly Xaa Pro 
    1625                 1630                 1635             


Xaa Ser  Ser Gln Pro Ser Val  Pro Gln Ala Gly Ser  Asn Xaa His 
    1640                 1645                 1650             


Arg Arg  Gly Ser Gly Ala Leu  Ile Phe Xaa Ile Pro  Glu Glu Gly 
    1655                 1660                 1665             


Asn Ser  Gln Pro Lys Gly Xaa  Lys Gly Gln Asn Lys  Gln Asp Glu 
    1670                 1675                 1680             


Asp Glu  Glu Val Pro Asp Arg  Leu Ser Tyr Leu Asp  Glu Gln Ala 
    1685                 1690                 1695             


Gly Xaa  Pro Pro Cys Ser Val  Leu Leu Pro Pro His  Arg Ala Gln 
    1700                 1705                 1710             


Arg Tyr  Met Asp Gly His Leu  Val Pro Arg Arg Arg  Leu Leu Pro 
    1715                 1720                 1725             


Pro Xaa  Pro Ala Gly Arg Lys  Pro Ser Phe Xaa Ile  Gln Cys Leu 
    1730                 1735                 1740             


Gln Arg  Gln Gly Ser Cys Glu  Asp Leu Pro Ile Pro  Gly Xaa Tyr 
    1745                 1750                 1755             


His Arg  Gly Arg Asn Ser Gly  Pro Asn Arg Ala Gln  Gly Ser Trp 
    1760                 1765                 1770             


Ala Xaa  Pro Pro Gln Arg Gly  Arg Leu Leu Tyr Ala  Pro Leu Leu 
    1775                 1780                 1785             


Leu Val  Glu Glu Gly Ala Ala  Gly Glu Gly Tyr Leu  Gly Arg Ser 
    1790                 1795                 1800             


Ser Gly  Pro Leu Arg Xaa Phe  Xaa Cys Leu His Val  Pro Gly Xaa 
    1805                 1810                 1815             


His Ser  Asp Pro Ser His Gly  Lys Arg Gly Ser Ala  Asp Ser Leu 
    1820                 1825                 1830             


Val Glu  Ala Val Leu Ile Ser  Glu Gly Leu Gly Leu  Phe Ala Arg 
    1835                 1840                 1845             


Asp Pro  Arg Phe Val Ala Leu  Ala Lys Gln Glu Ile  Ala Asp Ala 
    1850                 1855                 1860             


Cys Arg  Leu Xaa Leu Asp Glu  Met Asp Asn Ala Ala  Ser Asp Leu 
    1865                 1870                 1875             


Leu Ala  Gln Gly Xaa Ser Ser  Leu Tyr Ser Asp Glu  Glu Ser Ile 
    1880                 1885                 1890             


Leu Ser  Arg Phe Asp Glu Glu  Asp Leu Gly Asp Glu  Met Ala Cys 
    1895                 1900                 1905             


Val His  Ala Leu 
    1910         


<210> 4695
<211> 277
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<400> 4695
Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe Ala Val Glu Met Val Val 
1               5                   10                  15      


Lys Met Val Ala Leu Gly Ile Phe Gly Lys Lys Cys Tyr Leu Gly Asp 
            20                  25                  30          


Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val Ile Ala Gly Met Leu Glu 
        35                  40                  45              


Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe Ser Ala Val Arg Xaa Val 
    50                  55                  60                  


Arg Val Leu Arg Pro Leu Arg Ala Ile Asn Arg Val Pro Ser Met Arg 
65                  70                  75                  80  


Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu Pro Met Leu Gly Asn Val 
                85                  90                  95      


Leu Leu Leu Cys Phe Phe Val Phe Phe Ile Phe Gly Ile Val Gly Val 
            100                 105                 110         


Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg Cys Phe Leu Pro Glu Asn 
        115                 120                 125             


Phe Ser Leu Pro Leu Ser Val Asp Leu Glu Arg Tyr Tyr Gln Xaa Glu 
    130                 135                 140                 


Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser Gln Pro Arg Glu Asn Gly 
145                 150                 155                 160 


Met Arg Ser Cys Arg Ser Val Pro Xaa Leu Arg Gly Asp Gly Gly Gly 
                165                 170                 175     


Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala Tyr Asn Ser Ser Ser Asn 
            180                 185                 190         


Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr Xaa Asn Cys Ser Ala Gly 
        195                 200                 205             


Glu His Asn Pro Phe Lys Gly Ala Ile Asn Phe Asp Asn Ile Gly Tyr 
    210                 215                 220                 


Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa Leu Glu Gly Trp Val Asp 
225                 230                 235                 240 


Ile Met Tyr Phe Val Met Asp Ala His Ser Phe Tyr Asn Phe Ile Tyr 
                245                 250                 255     


Phe Ile Leu Leu Ile Ile Phe Leu Ala Leu Arg Xaa Ser Pro Val Glu 
            260                 265                 270         


Arg Ala Ser Ile Ile 
        275         


<210> 4696
<211> 1555
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1492)..(1492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1550)..(1550)
<223> Selenocysteine

<400> 4696
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Val  Ser Pro Arg Leu Arg  Gly Gly Ala Val Val  Lys Glu Ala 
    1475                 1480                 1485             


Gly Gly  Gly Xaa Gly Pro Cys  Leu Val Ile Pro Ala  Asp Ser Gly 
    1490                 1495                 1500             


Gly Gly  Gly Leu His Glu Glu  Ile Ser Pro Ser His  Pro Leu Leu 
    1505                 1510                 1515             


Ser Asn  His Gln His Val Ala  Lys Pro Ser Pro Ser  His Ser Ala 
    1520                 1525                 1530             


Pro Lys  Ser Gly Pro Met Gly  Ser Leu Ala Val Leu  Lys Asp Glu 
    1535                 1540                 1545             


Glu Xaa  Glu Ala Gln Arg Gly  
    1550                 1555 


<210> 4697
<211> 1735
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1577)..(1577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1610)..(1610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1650)..(1650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1665)..(1665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1694)..(1694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1710)..(1710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1714)..(1714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1717)..(1717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1730)..(1730)
<223> Selenocysteine

<400> 4697
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Gly Asp Ala Asn Lys Ser 
                965                 970                 975     


Glu Ser Glu Pro Asp Phe Phe Ser Pro Ser Leu Asp Gly Asp Gly Asp 
            980                 985                 990         


Arg Lys Lys Cys Leu Ala Leu Val  Ser Leu Gly Glu His  Pro Glu Leu 
        995                 1000                 1005             


Arg Lys  Ser Leu Leu Pro Pro  Leu Ile Ile His Xaa  Ala Ala Xaa 
    1010                 1015                 1020             


Pro Met  Ser Leu Pro Lys Ser  Xaa Ser Xaa Gly Leu  Gly Glu Ala 
    1025                 1030                 1035             


Leu Gly  Pro Ala Ser Arg Arg  Xaa Ser Ser Ser Gly  Ser Ala Glu 
    1040                 1045                 1050             


Pro Gly  Ala Ala His Glu Met  Lys Ser Pro Pro Ser  Ala Arg Ser 
    1055                 1060                 1065             


Ser Pro  His Ser Pro Trp Ser  Ala Ala Ser Ser Trp  Xaa Ser Arg 
    1070                 1075                 1080             


Arg Ser  Ser Arg Asn Ser Leu  Gly Arg Ala Pro Ser  Leu Lys Arg 
    1085                 1090                 1095             


Arg Ser  Pro Ser Gly Glu Arg  Arg Ser Leu Leu Ser  Gly Glu Gly 
    1100                 1105                 1110             


Gln Glu  Ser Gln Asp Glu Glu  Glu Ser Ser Glu Glu  Glu Arg Ala 
    1115                 1120                 1125             


Ser Pro  Ala Gly Ser Asp His  Arg His Arg Gly Ser  Leu Glu Arg 
    1130                 1135                 1140             


Glu Ala  Lys Ser Ser Phe Asp  Leu Pro Asp Xaa Leu  Gln Val Pro 
    1145                 1150                 1155             


Gly Leu  His Arg Xaa Ala Ser  Gly Arg Gly Ser Ala  Ser Glu His 
    1160                 1165                 1170             


Gln Asp  Cys Asn Gly Lys Ser  Ala Ser Gly Arg Leu  Ala Arg Ala 
    1175                 1180                 1185             


Leu Arg  Pro Asp Asp Pro Pro  Leu Asp Gly Asp Asp  Ala Asp Asp 
    1190                 1195                 1200             


Glu Gly  Asn Leu Ser Lys Gly  Glu Arg Val Arg Ala  Trp Ile Arg 
    1205                 1210                 1215             


Ala Arg  Leu Pro Ala Cys Cys  Leu Glu Arg Asp Ser  Trp Ser Ala 
    1220                 1225                 1230             


Tyr Ile  Phe Pro Pro Gln Ser  Arg Phe Arg Leu Leu  Cys His Arg 
    1235                 1240                 1245             


Ile Ile  Xaa His Lys Met Phe  Asp His Val Val Leu  Val Ile Ile 
    1250                 1255                 1260             


Phe Leu  Asn Cys Ile Xaa Ile  Ala Met Glu Arg Pro  Lys Ile Asp 
    1265                 1270                 1275             


Pro His  Ser Ala Glu Arg Ile  Phe Leu Xaa Leu Ser  Asn Tyr Ile 
    1280                 1285                 1290             


Phe Xaa  Ala Val Phe Leu Ala  Glu Met Xaa Val Lys  Val Val Ala 
    1295                 1300                 1305             


Leu Gly  Trp Cys Phe Gly Glu  Gln Ala Tyr Leu Arg  Ser Ser Trp 
    1310                 1315                 1320             


Asn Val  Leu Asp Gly Leu Leu  Val Leu Ile Ser Val  Ile Asp Ile 
    1325                 1330                 1335             


Leu Val  Ser Met Val Ser Asp  Ser Gly Xaa Lys Ile  Leu Gly Met 
    1340                 1345                 1350             


Leu Arg  Val Leu Arg Leu Leu  Arg Xaa Leu Arg Pro  Leu Arg Val 
    1355                 1360                 1365             


Ile Ser  Arg Ala Gln Gly Leu  Lys Leu Val Val Glu  Xaa Leu Met 
    1370                 1375                 1380             


Ser Ser  Leu Lys Pro Ile Gly  Asn Ile Val Val Ile  Cys Cys Ala 
    1385                 1390                 1395             


Phe Phe  Ile Ile Phe Gly Ile  Leu Gly Val Gln Leu  Phe Lys Gly 
    1400                 1405                 1410             


Lys Phe  Phe Val Cys Gln Gly  Glu Asp Xaa Arg Asn  Ile Xaa Asn 
    1415                 1420                 1425             


Lys Ser  Asp Cys Ala Glu Ala  Ser Tyr Arg Trp Val  Arg His Lys 
    1430                 1435                 1440             


Tyr Asn  Phe Asp Asn Leu Gly  Gln Ala Leu Met Ser  Leu Phe Val 
    1445                 1450                 1455             


Leu Ala  Ser Lys Asp Gly Trp  Val Asp Ile Met Tyr  Asp Gly Leu 
    1460                 1465                 1470             


Asp Ala  Val Gly Val Asp Gln  Gln Pro Ile Met Asn  His Asn Pro 
    1475                 1480                 1485             


Trp Met  Leu Leu Tyr Phe Ile  Ser Phe Leu Leu Ile  Val Ala Phe 
    1490                 1495                 1500             


Phe Val  Leu Asn Met Phe Val  Gly Val Val Val Glu  Asn Phe His 
    1505                 1510                 1515             


Lys Cys  Arg Gln His Gln Glu  Glu Glu Glu Ala Arg  Arg Arg Glu 
    1520                 1525                 1530             


Glu Lys  Arg Leu Arg Arg Leu  Glu Lys Lys Arg Arg  Lys Ala Gln 
    1535                 1540                 1545             


Cys Lys  Pro Tyr Tyr Ser Asp  Tyr Ser Arg Phe Arg  Leu Leu Val 
    1550                 1555                 1560             


His His  Leu Cys Xaa Ser His  Tyr Leu Asp Leu Phe  Ile Xaa Gly 
    1565                 1570                 1575             


Val Ile  Gly Leu Asn Val Val  Xaa Met Ala Met Glu  His Tyr Gln 
    1580                 1585                 1590             


Gln Pro  Gln Ile Leu Asp Glu  Ala Leu Lys Ile Cys  Asn Tyr Ile 
    1595                 1600                 1605             


Phe Xaa  Val Ile Phe Val Leu  Glu Ser Val Phe Lys  Leu Val Ala 
    1610                 1615                 1620             


Phe Gly  Phe Arg Arg Phe Phe  Gln Asp Arg Trp Asn  Gln Leu Asp 
    1625                 1630                 1635             


Leu Ala  Ile Val Leu Leu Ser  Ile Met Gly Ile Xaa  Leu Glu Glu 
    1640                 1645                 1650             


Ile Glu  Val Asn Ala Ser Leu  Pro Ile Asn Pro Xaa  Ile Ile Arg 
    1655                 1660                 1665             


Ile Met  Arg Val Leu Arg Ile  Ala Arg Val Leu Lys  Leu Leu Lys 
    1670                 1675                 1680             


Met Ala  Val Gly Met Arg Ala  Leu Leu Asp Xaa Val  Met Gln Ala 
    1685                 1690                 1695             


Leu Pro  Gln Leu Trp Ala Trp  Ser Ser Leu Glu Xaa  Trp Ser Val 
    1700                 1705                 1710             


Xaa Arg  His Xaa Pro Val Arg  Ala Trp Ala Val Met  Pro Pro Phe 
    1715                 1720                 1725             


Gly Xaa  Leu Ala Trp Pro Ser  
    1730                 1735 


<210> 4698
<211> 1746
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1595)..(1595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1604)..(1604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1628)..(1628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1668)..(1668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1683)..(1683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1712)..(1712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1725)..(1725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1728)..(1728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1741)..(1741)
<223> Selenocysteine

<400> 4698
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Gly Asp Ala Asn Lys Ser 
                965                 970                 975     


Glu Ser Glu Pro Asp Phe Phe Ser Pro Ser Leu Asp Gly Asp Gly Asp 
            980                 985                 990         


Arg Lys Lys Cys Leu Ala Leu Val  Ser Leu Gly Glu His  Pro Glu Leu 
        995                 1000                 1005             


Arg Lys  Ser Leu Leu Pro Pro  Leu Ile Ile His Xaa  Ala Ala Xaa 
    1010                 1015                 1020             


Pro Met  Ser Leu Pro Lys Ser  Xaa Ser Xaa Gly Leu  Gly Glu Ala 
    1025                 1030                 1035             


Leu Gly  Pro Ala Ser Arg Arg  Xaa Ser Ser Ser Gly  Ser Ala Glu 
    1040                 1045                 1050             


Pro Gly  Ala Ala His Glu Met  Lys Ser Pro Pro Ser  Ala Arg Ser 
    1055                 1060                 1065             


Ser Pro  His Ser Pro Trp Ser  Ala Ala Ser Ser Trp  Xaa Ser Arg 
    1070                 1075                 1080             


Arg Ser  Ser Arg Asn Ser Leu  Gly Arg Ala Pro Ser  Leu Lys Arg 
    1085                 1090                 1095             


Arg Ser  Pro Ser Gly Glu Arg  Arg Ser Leu Leu Ser  Gly Glu Gly 
    1100                 1105                 1110             


Gln Glu  Ser Gln Asp Glu Glu  Glu Ser Ser Glu Glu  Glu Arg Ala 
    1115                 1120                 1125             


Ser Pro  Ala Gly Ser Asp His  Arg His Arg Gly Ser  Leu Glu Arg 
    1130                 1135                 1140             


Glu Ala  Lys Ser Ser Phe Asp  Leu Pro Asp Xaa Leu  Gln Val Pro 
    1145                 1150                 1155             


Gly Leu  His Arg Xaa Ala Ser  Gly Arg Gly Ser Ala  Ser Glu His 
    1160                 1165                 1170             


Gln Asp  Cys Asn Gly Lys Ser  Ala Ser Gly Arg Leu  Ala Arg Ala 
    1175                 1180                 1185             


Leu Arg  Pro Asp Asp Pro Pro  Leu Asp Gly Asp Asp  Ala Asp Asp 
    1190                 1195                 1200             


Glu Gly  Asn Leu Ser Lys Gly  Glu Arg Val Arg Ala  Trp Ile Arg 
    1205                 1210                 1215             


Ala Arg  Leu Pro Ala Cys Cys  Leu Glu Arg Asp Ser  Trp Ser Ala 
    1220                 1225                 1230             


Tyr Ile  Phe Pro Pro Gln Ser  Arg Phe Arg Leu Leu  Cys His Arg 
    1235                 1240                 1245             


Ile Ile  Xaa His Lys Met Phe  Asp His Val Val Leu  Val Ile Ile 
    1250                 1255                 1260             


Phe Leu  Asn Cys Ile Xaa Ile  Ala Met Glu Arg Pro  Lys Ile Asp 
    1265                 1270                 1275             


Pro His  Ser Ala Glu Arg Ile  Phe Leu Xaa Leu Ser  Asn Tyr Ile 
    1280                 1285                 1290             


Phe Xaa  Ala Val Phe Leu Ala  Glu Met Xaa Val Lys  Val Val Ala 
    1295                 1300                 1305             


Leu Gly  Trp Cys Phe Gly Glu  Gln Ala Tyr Leu Arg  Ser Ser Trp 
    1310                 1315                 1320             


Asn Val  Leu Asp Gly Leu Leu  Val Leu Ile Ser Val  Ile Asp Ile 
    1325                 1330                 1335             


Leu Val  Ser Met Val Ser Asp  Ser Gly Xaa Lys Ile  Leu Gly Met 
    1340                 1345                 1350             


Leu Arg  Val Leu Arg Leu Leu  Arg Xaa Leu Arg Pro  Leu Arg Val 
    1355                 1360                 1365             


Ile Ser  Arg Ala Gln Gly Leu  Lys Leu Val Val Glu  Xaa Leu Met 
    1370                 1375                 1380             


Ser Ser  Leu Lys Pro Ile Gly  Asn Ile Val Val Ile  Cys Cys Ala 
    1385                 1390                 1395             


Phe Phe  Ile Ile Phe Gly Ile  Leu Gly Val Gln Leu  Phe Lys Gly 
    1400                 1405                 1410             


Lys Phe  Phe Val Cys Gln Gly  Glu Asp Xaa Arg Asn  Ile Xaa Asn 
    1415                 1420                 1425             


Lys Ser  Asp Cys Ala Glu Ala  Ser Tyr Arg Trp Val  Arg His Lys 
    1430                 1435                 1440             


Tyr Asn  Phe Asp Asn Leu Gly  Gln Ala Leu Met Ser  Leu Phe Val 
    1445                 1450                 1455             


Leu Ala  Ser Lys Asp Gly Trp  Val Asp Ile Met Tyr  Asp Gly Leu 
    1460                 1465                 1470             


Asp Ala  Val Gly Val Asp Gln  Gln Pro Ile Met Asn  His Asn Pro 
    1475                 1480                 1485             


Trp Met  Leu Leu Tyr Phe Ile  Ser Phe Leu Leu Ile  Val Ala Phe 
    1490                 1495                 1500             


Phe Val  Leu Asn Met Phe Val  Gly Val Val Val Glu  Asn Phe His 
    1505                 1510                 1515             


Lys Cys  Arg Gln His Gln Glu  Glu Glu Glu Ala Arg  Arg Arg Glu 
    1520                 1525                 1530             


Glu Lys  Arg Leu Arg Arg Leu  Glu Lys Lys Arg Arg  Asn Leu Met 
    1535                 1540                 1545             


Leu Asp  Asp Val Ile Ala Ser  Gly Ser Ser Ala Ser  Ala Ala Ser 
    1550                 1555                 1560             


Glu Ala  Gln Cys Lys Pro Tyr  Tyr Ser Asp Tyr Ser  Arg Phe Arg 
    1565                 1570                 1575             


Leu Leu  Val His His Leu Cys  Xaa Ser His Tyr Leu  Asp Leu Phe 
    1580                 1585                 1590             


Ile Xaa  Gly Val Ile Gly Leu  Asn Val Val Xaa Met  Ala Met Glu 
    1595                 1600                 1605             


His Tyr  Gln Gln Pro Gln Ile  Leu Asp Glu Ala Leu  Lys Ile Cys 
    1610                 1615                 1620             


Asn Tyr  Ile Phe Xaa Val Ile  Phe Val Leu Glu Ser  Val Phe Lys 
    1625                 1630                 1635             


Leu Val  Ala Phe Gly Phe Arg  Arg Phe Phe Gln Asp  Arg Trp Asn 
    1640                 1645                 1650             


Gln Leu  Asp Leu Ala Ile Val  Leu Leu Ser Ile Met  Gly Ile Xaa 
    1655                 1660                 1665             


Leu Glu  Glu Ile Glu Val Asn  Ala Ser Leu Pro Ile  Asn Pro Xaa 
    1670                 1675                 1680             


Ile Ile  Arg Ile Met Arg Val  Leu Arg Ile Ala Arg  Val Leu Lys 
    1685                 1690                 1695             


Leu Leu  Lys Met Ala Val Gly  Met Arg Ala Leu Leu  Asp Xaa Leu 
    1700                 1705                 1710             


Trp Ala  Trp Ser Ser Leu Glu  Xaa Trp Ser Val Xaa  Arg His Xaa 
    1715                 1720                 1725             


Pro Val  Arg Ala Trp Ala Val  Met Pro Pro Phe Gly  Xaa Leu Ala 
    1730                 1735                 1740             


Trp Pro  Ser 
    1745     


<210> 4699
<211> 1753
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1595)..(1595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1604)..(1604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1628)..(1628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1668)..(1668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1683)..(1683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1712)..(1712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1728)..(1728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1732)..(1732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1735)..(1735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1748)..(1748)
<223> Selenocysteine

<400> 4699
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Gly Asp Ala Asn Lys Ser 
                965                 970                 975     


Glu Ser Glu Pro Asp Phe Phe Ser Pro Ser Leu Asp Gly Asp Gly Asp 
            980                 985                 990         


Arg Lys Lys Cys Leu Ala Leu Val  Ser Leu Gly Glu His  Pro Glu Leu 
        995                 1000                 1005             


Arg Lys  Ser Leu Leu Pro Pro  Leu Ile Ile His Xaa  Ala Ala Xaa 
    1010                 1015                 1020             


Pro Met  Ser Leu Pro Lys Ser  Xaa Ser Xaa Gly Leu  Gly Glu Ala 
    1025                 1030                 1035             


Leu Gly  Pro Ala Ser Arg Arg  Xaa Ser Ser Ser Gly  Ser Ala Glu 
    1040                 1045                 1050             


Pro Gly  Ala Ala His Glu Met  Lys Ser Pro Pro Ser  Ala Arg Ser 
    1055                 1060                 1065             


Ser Pro  His Ser Pro Trp Ser  Ala Ala Ser Ser Trp  Xaa Ser Arg 
    1070                 1075                 1080             


Arg Ser  Ser Arg Asn Ser Leu  Gly Arg Ala Pro Ser  Leu Lys Arg 
    1085                 1090                 1095             


Arg Ser  Pro Ser Gly Glu Arg  Arg Ser Leu Leu Ser  Gly Glu Gly 
    1100                 1105                 1110             


Gln Glu  Ser Gln Asp Glu Glu  Glu Ser Ser Glu Glu  Glu Arg Ala 
    1115                 1120                 1125             


Ser Pro  Ala Gly Ser Asp His  Arg His Arg Gly Ser  Leu Glu Arg 
    1130                 1135                 1140             


Glu Ala  Lys Ser Ser Phe Asp  Leu Pro Asp Xaa Leu  Gln Val Pro 
    1145                 1150                 1155             


Gly Leu  His Arg Xaa Ala Ser  Gly Arg Gly Ser Ala  Ser Glu His 
    1160                 1165                 1170             


Gln Asp  Cys Asn Gly Lys Ser  Ala Ser Gly Arg Leu  Ala Arg Ala 
    1175                 1180                 1185             


Leu Arg  Pro Asp Asp Pro Pro  Leu Asp Gly Asp Asp  Ala Asp Asp 
    1190                 1195                 1200             


Glu Gly  Asn Leu Ser Lys Gly  Glu Arg Val Arg Ala  Trp Ile Arg 
    1205                 1210                 1215             


Ala Arg  Leu Pro Ala Cys Cys  Leu Glu Arg Asp Ser  Trp Ser Ala 
    1220                 1225                 1230             


Tyr Ile  Phe Pro Pro Gln Ser  Arg Phe Arg Leu Leu  Cys His Arg 
    1235                 1240                 1245             


Ile Ile  Xaa His Lys Met Phe  Asp His Val Val Leu  Val Ile Ile 
    1250                 1255                 1260             


Phe Leu  Asn Cys Ile Xaa Ile  Ala Met Glu Arg Pro  Lys Ile Asp 
    1265                 1270                 1275             


Pro His  Ser Ala Glu Arg Ile  Phe Leu Xaa Leu Ser  Asn Tyr Ile 
    1280                 1285                 1290             


Phe Xaa  Ala Val Phe Leu Ala  Glu Met Xaa Val Lys  Val Val Ala 
    1295                 1300                 1305             


Leu Gly  Trp Cys Phe Gly Glu  Gln Ala Tyr Leu Arg  Ser Ser Trp 
    1310                 1315                 1320             


Asn Val  Leu Asp Gly Leu Leu  Val Leu Ile Ser Val  Ile Asp Ile 
    1325                 1330                 1335             


Leu Val  Ser Met Val Ser Asp  Ser Gly Xaa Lys Ile  Leu Gly Met 
    1340                 1345                 1350             


Leu Arg  Val Leu Arg Leu Leu  Arg Xaa Leu Arg Pro  Leu Arg Val 
    1355                 1360                 1365             


Ile Ser  Arg Ala Gln Gly Leu  Lys Leu Val Val Glu  Xaa Leu Met 
    1370                 1375                 1380             


Ser Ser  Leu Lys Pro Ile Gly  Asn Ile Val Val Ile  Cys Cys Ala 
    1385                 1390                 1395             


Phe Phe  Ile Ile Phe Gly Ile  Leu Gly Val Gln Leu  Phe Lys Gly 
    1400                 1405                 1410             


Lys Phe  Phe Val Cys Gln Gly  Glu Asp Xaa Arg Asn  Ile Xaa Asn 
    1415                 1420                 1425             


Lys Ser  Asp Cys Ala Glu Ala  Ser Tyr Arg Trp Val  Arg His Lys 
    1430                 1435                 1440             


Tyr Asn  Phe Asp Asn Leu Gly  Gln Ala Leu Met Ser  Leu Phe Val 
    1445                 1450                 1455             


Leu Ala  Ser Lys Asp Gly Trp  Val Asp Ile Met Tyr  Asp Gly Leu 
    1460                 1465                 1470             


Asp Ala  Val Gly Val Asp Gln  Gln Pro Ile Met Asn  His Asn Pro 
    1475                 1480                 1485             


Trp Met  Leu Leu Tyr Phe Ile  Ser Phe Leu Leu Ile  Val Ala Phe 
    1490                 1495                 1500             


Phe Val  Leu Asn Met Phe Val  Gly Val Val Val Glu  Asn Phe His 
    1505                 1510                 1515             


Lys Cys  Arg Gln His Gln Glu  Glu Glu Glu Ala Arg  Arg Arg Glu 
    1520                 1525                 1530             


Glu Lys  Arg Leu Arg Arg Leu  Glu Lys Lys Arg Arg  Asn Leu Met 
    1535                 1540                 1545             


Leu Asp  Asp Val Ile Ala Ser  Gly Ser Ser Ala Ser  Ala Ala Ser 
    1550                 1555                 1560             


Glu Ala  Gln Cys Lys Pro Tyr  Tyr Ser Asp Tyr Ser  Arg Phe Arg 
    1565                 1570                 1575             


Leu Leu  Val His His Leu Cys  Xaa Ser His Tyr Leu  Asp Leu Phe 
    1580                 1585                 1590             


Ile Xaa  Gly Val Ile Gly Leu  Asn Val Val Xaa Met  Ala Met Glu 
    1595                 1600                 1605             


His Tyr  Gln Gln Pro Gln Ile  Leu Asp Glu Ala Leu  Lys Ile Cys 
    1610                 1615                 1620             


Asn Tyr  Ile Phe Xaa Val Ile  Phe Val Leu Glu Ser  Val Phe Lys 
    1625                 1630                 1635             


Leu Val  Ala Phe Gly Phe Arg  Arg Phe Phe Gln Asp  Arg Trp Asn 
    1640                 1645                 1650             


Gln Leu  Asp Leu Ala Ile Val  Leu Leu Ser Ile Met  Gly Ile Xaa 
    1655                 1660                 1665             


Leu Glu  Glu Ile Glu Val Asn  Ala Ser Leu Pro Ile  Asn Pro Xaa 
    1670                 1675                 1680             


Ile Ile  Arg Ile Met Arg Val  Leu Arg Ile Ala Arg  Val Leu Lys 
    1685                 1690                 1695             


Leu Leu  Lys Met Ala Val Gly  Met Arg Ala Leu Leu  Asp Xaa Val 
    1700                 1705                 1710             


Met Gln  Ala Leu Pro Gln Leu  Trp Ala Trp Ser Ser  Leu Glu Xaa 
    1715                 1720                 1725             


Trp Ser  Val Xaa Arg His Xaa  Pro Val Arg Ala Trp  Ala Val Met 
    1730                 1735                 1740             


Pro Pro  Phe Gly Xaa Leu Ala  Trp Pro Ser 
    1745                 1750             


<210> 4700
<211> 1758
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1591)..(1591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1600)..(1600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1673)..(1673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1688)..(1688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1717)..(1717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1733)..(1733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1737)..(1737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1753)..(1753)
<223> Selenocysteine

<400> 4700
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Pro  Ile Met Asn His Asn  Pro Trp Met Leu Leu  Tyr Phe Ile 
    1505                 1510                 1515             


Ser Phe  Leu Leu Ile Val Ala  Phe Phe Val Leu Asn  Met Phe Val 
    1520                 1525                 1530             


Gly Val  Val Val Glu Asn Phe  His Lys Cys Arg Gln  His Gln Glu 
    1535                 1540                 1545             


Glu Glu  Glu Ala Arg Arg Arg  Glu Glu Lys Arg Leu  Arg Arg Leu 
    1550                 1555                 1560             


Glu Lys  Lys Arg Arg Lys Ala  Gln Cys Lys Pro Tyr  Tyr Ser Asp 
    1565                 1570                 1575             


Tyr Ser  Arg Phe Arg Leu Leu  Val His His Leu Cys  Xaa Ser His 
    1580                 1585                 1590             


Tyr Leu  Asp Leu Phe Ile Xaa  Gly Val Ile Gly Leu  Asn Val Val 
    1595                 1600                 1605             


Xaa Met  Ala Met Glu His Tyr  Gln Gln Pro Gln Ile  Leu Asp Glu 
    1610                 1615                 1620             


Ala Leu  Lys Ile Cys Asn Tyr  Ile Phe Xaa Val Ile  Phe Val Leu 
    1625                 1630                 1635             


Glu Ser  Val Phe Lys Leu Val  Ala Phe Gly Phe Arg  Arg Phe Phe 
    1640                 1645                 1650             


Gln Asp  Arg Trp Asn Gln Leu  Asp Leu Ala Ile Val  Leu Leu Ser 
    1655                 1660                 1665             


Ile Met  Gly Ile Xaa Leu Glu  Glu Ile Glu Val Asn  Ala Ser Leu 
    1670                 1675                 1680             


Pro Ile  Asn Pro Xaa Ile Ile  Arg Ile Met Arg Val  Leu Arg Ile 
    1685                 1690                 1695             


Ala Arg  Val Leu Lys Leu Leu  Lys Met Ala Val Gly  Met Arg Ala 
    1700                 1705                 1710             


Leu Leu  Asp Xaa Val Met Gln  Ala Leu Pro Gln Leu  Trp Ala Trp 
    1715                 1720                 1725             


Ser Ser  Leu Glu Xaa Trp Ser  Val Xaa Arg His Xaa  Pro Val Arg 
    1730                 1735                 1740             


Ala Trp  Ala Val Met Pro Pro  Phe Gly Xaa Leu Ala  Trp Pro Ser 
    1745                 1750                 1755             


<210> 4701
<211> 1765
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1598)..(1598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1616)..(1616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1680)..(1680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1695)..(1695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1724)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1744)..(1744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1747)..(1747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<400> 4701
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Pro  Ile Met Asn His Asn  Pro Trp Met Leu Leu  Tyr Phe Ile 
    1505                 1510                 1515             


Ser Phe  Leu Leu Ile Val Ala  Phe Phe Val Leu Asn  Met Phe Val 
    1520                 1525                 1530             


Gly Val  Val Val Glu Asn Phe  His Lys Cys Arg Gln  His Gln Glu 
    1535                 1540                 1545             


Glu Glu  Glu Ala Arg Arg Arg  Glu Glu Lys Arg Leu  Arg Arg Leu 
    1550                 1555                 1560             


Glu Lys  Lys Arg Arg Ser Lys  Glu Lys Gln Met Ala  Glu Ala Gln 
    1565                 1570                 1575             


Cys Lys  Pro Tyr Tyr Ser Asp  Tyr Ser Arg Phe Arg  Leu Leu Val 
    1580                 1585                 1590             


His His  Leu Cys Xaa Ser His  Tyr Leu Asp Leu Phe  Ile Xaa Gly 
    1595                 1600                 1605             


Val Ile  Gly Leu Asn Val Val  Xaa Met Ala Met Glu  His Tyr Gln 
    1610                 1615                 1620             


Gln Pro  Gln Ile Leu Asp Glu  Ala Leu Lys Ile Cys  Asn Tyr Ile 
    1625                 1630                 1635             


Phe Xaa  Val Ile Phe Val Leu  Glu Ser Val Phe Lys  Leu Val Ala 
    1640                 1645                 1650             


Phe Gly  Phe Arg Arg Phe Phe  Gln Asp Arg Trp Asn  Gln Leu Asp 
    1655                 1660                 1665             


Leu Ala  Ile Val Leu Leu Ser  Ile Met Gly Ile Xaa  Leu Glu Glu 
    1670                 1675                 1680             


Ile Glu  Val Asn Ala Ser Leu  Pro Ile Asn Pro Xaa  Ile Ile Arg 
    1685                 1690                 1695             


Ile Met  Arg Val Leu Arg Ile  Ala Arg Val Leu Lys  Leu Leu Lys 
    1700                 1705                 1710             


Met Ala  Val Gly Met Arg Ala  Leu Leu Asp Xaa Val  Met Gln Ala 
    1715                 1720                 1725             


Leu Pro  Gln Leu Trp Ala Trp  Ser Ser Leu Glu Xaa  Trp Ser Val 
    1730                 1735                 1740             


Xaa Arg  His Xaa Pro Val Arg  Ala Trp Ala Val Met  Pro Pro Phe 
    1745                 1750                 1755             


Gly Xaa  Leu Ala Trp Pro Ser  
    1760                 1765 


<210> 4702
<211> 1776
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1618)..(1618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1627)..(1627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1651)..(1651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1691)..(1691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1706)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1735)..(1735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1751)..(1751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1755)..(1755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1758)..(1758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1771)..(1771)
<223> Selenocysteine

<400> 4702
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Pro  Ile Met Asn His Asn  Pro Trp Met Leu Leu  Tyr Phe Ile 
    1505                 1510                 1515             


Ser Phe  Leu Leu Ile Val Ala  Phe Phe Val Leu Asn  Met Phe Val 
    1520                 1525                 1530             


Gly Val  Val Val Glu Asn Phe  His Lys Cys Arg Gln  His Gln Glu 
    1535                 1540                 1545             


Glu Glu  Glu Ala Arg Arg Arg  Glu Glu Lys Arg Leu  Arg Arg Leu 
    1550                 1555                 1560             


Glu Lys  Lys Arg Arg Asn Leu  Met Leu Asp Asp Val  Ile Ala Ser 
    1565                 1570                 1575             


Gly Ser  Ser Ala Ser Ala Ala  Ser Glu Ala Gln Cys  Lys Pro Tyr 
    1580                 1585                 1590             


Tyr Ser  Asp Tyr Ser Arg Phe  Arg Leu Leu Val His  His Leu Cys 
    1595                 1600                 1605             


Xaa Ser  His Tyr Leu Asp Leu  Phe Ile Xaa Gly Val  Ile Gly Leu 
    1610                 1615                 1620             


Asn Val  Val Xaa Met Ala Met  Glu His Tyr Gln Gln  Pro Gln Ile 
    1625                 1630                 1635             


Leu Asp  Glu Ala Leu Lys Ile  Cys Asn Tyr Ile Phe  Xaa Val Ile 
    1640                 1645                 1650             


Phe Val  Leu Glu Ser Val Phe  Lys Leu Val Ala Phe  Gly Phe Arg 
    1655                 1660                 1665             


Arg Phe  Phe Gln Asp Arg Trp  Asn Gln Leu Asp Leu  Ala Ile Val 
    1670                 1675                 1680             


Leu Leu  Ser Ile Met Gly Ile  Xaa Leu Glu Glu Ile  Glu Val Asn 
    1685                 1690                 1695             


Ala Ser  Leu Pro Ile Asn Pro  Xaa Ile Ile Arg Ile  Met Arg Val 
    1700                 1705                 1710             


Leu Arg  Ile Ala Arg Val Leu  Lys Leu Leu Lys Met  Ala Val Gly 
    1715                 1720                 1725             


Met Arg  Ala Leu Leu Asp Xaa  Val Met Gln Ala Leu  Pro Gln Leu 
    1730                 1735                 1740             


Trp Ala  Trp Ser Ser Leu Glu  Xaa Trp Ser Val Xaa  Arg His Xaa 
    1745                 1750                 1755             


Pro Val  Arg Ala Trp Ala Val  Met Pro Pro Phe Gly  Xaa Leu Ala 
    1760                 1765                 1770             


Trp Pro  Ser 
    1775     


<210> 4703
<211> 2171
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1575)..(1575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1584)..(1584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1593)..(1593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1617)..(1617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1672)..(1672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1701)..(1701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1739)..(1739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1750)..(1750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1766)..(1766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1777)..(1777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1786)..(1786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1803)..(1803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1843)..(1843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1893)..(1893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1899)..(1899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1908)..(1908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1917)..(1917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1932)..(1932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1962)..(1962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1983)..(1983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1986)..(1986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2011)..(2011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2053)..(2053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2079)..(2079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2106)..(2106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2117)..(2117)
<223> Selenocysteine

<400> 4703
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Gly Asp Ala Asn Lys Ser 
                965                 970                 975     


Glu Ser Glu Pro Asp Phe Phe Ser Pro Ser Leu Asp Gly Asp Gly Asp 
            980                 985                 990         


Arg Lys Lys Cys Leu Ala Leu Val  Ser Leu Gly Glu His  Pro Glu Leu 
        995                 1000                 1005             


Arg Lys  Ser Leu Leu Pro Pro  Leu Ile Ile His Xaa  Ala Ala Xaa 
    1010                 1015                 1020             


Pro Met  Ser Leu Pro Lys Ser  Xaa Ser Xaa Gly Leu  Gly Glu Ala 
    1025                 1030                 1035             


Leu Gly  Pro Ala Ser Arg Arg  Xaa Ser Ser Ser Gly  Ser Ala Glu 
    1040                 1045                 1050             


Pro Gly  Ala Ala His Glu Met  Lys Ser Pro Pro Ser  Ala Arg Ser 
    1055                 1060                 1065             


Ser Pro  His Ser Pro Trp Ser  Ala Ala Ser Ser Trp  Xaa Ser Arg 
    1070                 1075                 1080             


Arg Ser  Ser Arg Asn Ser Leu  Gly Arg Ala Pro Ser  Leu Lys Arg 
    1085                 1090                 1095             


Arg Ser  Pro Ser Gly Glu Arg  Arg Ser Leu Leu Ser  Gly Glu Gly 
    1100                 1105                 1110             


Gln Glu  Ser Gln Asp Glu Glu  Glu Ser Ser Glu Glu  Glu Arg Ala 
    1115                 1120                 1125             


Ser Pro  Ala Gly Ser Asp His  Arg His Arg Gly Ser  Leu Glu Arg 
    1130                 1135                 1140             


Glu Ala  Lys Ser Ser Phe Asp  Leu Pro Asp Xaa Leu  Gln Val Pro 
    1145                 1150                 1155             


Gly Leu  His Arg Xaa Ala Ser  Gly Arg Gly Ser Ala  Ser Glu His 
    1160                 1165                 1170             


Gln Asp  Cys Asn Gly Lys Ser  Ala Ser Gly Arg Leu  Ala Arg Ala 
    1175                 1180                 1185             


Leu Arg  Pro Asp Asp Pro Pro  Leu Asp Gly Asp Asp  Ala Asp Asp 
    1190                 1195                 1200             


Glu Gly  Asn Leu Ser Lys Gly  Glu Arg Val Arg Ala  Trp Ile Arg 
    1205                 1210                 1215             


Ala Arg  Leu Pro Ala Cys Cys  Leu Glu Arg Asp Ser  Trp Ser Ala 
    1220                 1225                 1230             


Tyr Ile  Phe Pro Pro Gln Ser  Arg Phe Arg Leu Leu  Cys His Arg 
    1235                 1240                 1245             


Ile Ile  Xaa His Lys Met Phe  Asp His Val Val Leu  Val Ile Ile 
    1250                 1255                 1260             


Phe Leu  Asn Cys Ile Xaa Ile  Ala Met Glu Arg Pro  Lys Ile Asp 
    1265                 1270                 1275             


Pro His  Ser Ala Glu Arg Ile  Phe Leu Xaa Leu Ser  Asn Tyr Ile 
    1280                 1285                 1290             


Phe Xaa  Ala Val Phe Leu Ala  Glu Met Xaa Val Lys  Val Val Ala 
    1295                 1300                 1305             


Leu Gly  Trp Cys Phe Gly Glu  Gln Ala Tyr Leu Arg  Ser Ser Trp 
    1310                 1315                 1320             


Asn Val  Leu Asp Gly Leu Leu  Val Leu Ile Ser Val  Ile Asp Ile 
    1325                 1330                 1335             


Leu Val  Ser Met Val Ser Asp  Ser Gly Xaa Lys Ile  Leu Gly Met 
    1340                 1345                 1350             


Leu Arg  Val Leu Arg Leu Leu  Arg Xaa Leu Arg Pro  Leu Arg Val 
    1355                 1360                 1365             


Ile Ser  Arg Ala Gln Gly Leu  Lys Leu Val Val Glu  Xaa Leu Met 
    1370                 1375                 1380             


Ser Ser  Leu Lys Pro Ile Gly  Asn Ile Val Val Ile  Cys Cys Ala 
    1385                 1390                 1395             


Phe Phe  Ile Ile Phe Gly Ile  Leu Gly Val Gln Leu  Phe Lys Gly 
    1400                 1405                 1410             


Lys Phe  Phe Val Cys Gln Gly  Glu Asp Xaa Arg Asn  Ile Xaa Asn 
    1415                 1420                 1425             


Lys Ser  Asp Cys Ala Glu Ala  Ser Tyr Arg Trp Val  Arg His Lys 
    1430                 1435                 1440             


Tyr Asn  Phe Asp Asn Leu Gly  Gln Ala Leu Met Ser  Leu Phe Val 
    1445                 1450                 1455             


Leu Ala  Ser Lys Asp Gly Trp  Val Asp Ile Met Tyr  Asp Gly Leu 
    1460                 1465                 1470             


Asp Ala  Val Gly Val Asp Gln  Gln Pro Ile Met Asn  His Asn Pro 
    1475                 1480                 1485             


Trp Met  Leu Leu Tyr Phe Ile  Ser Phe Leu Leu Ile  Val Ala Phe 
    1490                 1495                 1500             


Phe Val  Leu Asn Met Phe Val  Gly Val Val Val Glu  Asn Phe His 
    1505                 1510                 1515             


Lys Cys  Arg Gln His Gln Glu  Glu Glu Glu Ala Arg  Arg Arg Glu 
    1520                 1525                 1530             


Glu Lys  Arg Leu Arg Arg Leu  Glu Lys Lys Arg Arg  Ser Lys Glu 
    1535                 1540                 1545             


Lys Gln  Met Ala Glu Ala Gln  Cys Lys Pro Tyr Tyr  Ser Asp Tyr 
    1550                 1555                 1560             


Ser Arg  Phe Arg Leu Leu Val  His His Leu Cys Xaa  Ser His Tyr 
    1565                 1570                 1575             


Leu Asp  Leu Phe Ile Xaa Gly  Val Ile Gly Leu Asn  Val Val Xaa 
    1580                 1585                 1590             


Met Ala  Met Glu His Tyr Gln  Gln Pro Gln Ile Leu  Asp Glu Ala 
    1595                 1600                 1605             


Leu Lys  Ile Cys Asn Tyr Ile  Phe Xaa Val Ile Phe  Val Leu Glu 
    1610                 1615                 1620             


Ser Val  Phe Lys Leu Val Ala  Phe Gly Phe Arg Arg  Phe Phe Gln 
    1625                 1630                 1635             


Asp Arg  Trp Asn Gln Leu Asp  Leu Ala Ile Val Leu  Leu Ser Ile 
    1640                 1645                 1650             


Met Gly  Ile Xaa Leu Glu Glu  Ile Glu Val Asn Ala  Ser Leu Pro 
    1655                 1660                 1665             


Ile Asn  Pro Xaa Ile Ile Arg  Ile Met Arg Val Leu  Arg Ile Ala 
    1670                 1675                 1680             


Arg Val  Leu Lys Leu Leu Lys  Met Ala Val Gly Met  Arg Ala Leu 
    1685                 1690                 1695             


Leu Asp  Xaa Val Met Gln Ala  Leu Pro Gln Val Gly  Asn Leu Gly 
    1700                 1705                 1710             


Leu Leu  Phe Met Leu Leu Phe  Phe Ile Phe Ala Ala  Leu Gly Val 
    1715                 1720                 1725             


Glu Leu  Phe Gly Asp Leu Glu  Cys Asp Glu Xaa His  Pro Cys Glu 
    1730                 1735                 1740             


Gly Leu  Gly Arg His Ala Xaa  Phe Arg Asn Phe Gly  Met Ala Phe 
    1745                 1750                 1755             


Leu Xaa  Leu Phe Arg Val Ser  Xaa Gly Asp Asn Trp  Asn Gly Ile 
    1760                 1765                 1770             


Met Lys  Asp Xaa Leu Arg Asp  Cys Asp Gln Glu Ser  Xaa Cys Tyr 
    1775                 1780                 1785             


Asn Xaa  Val Ile Ser Pro Ile  Tyr Phe Val Ser Phe  Val Leu Xaa 
    1790                 1795                 1800             


Ala Gln  Phe Val Leu Val Asn  Val Val Ile Ala Val  Leu Met Lys 
    1805                 1810                 1815             


His Leu  Glu Glu Ser Asn Lys  Glu Ala Lys Glu Glu  Ala Glu Leu 
    1820                 1825                 1830             


Glu Ala  Glu Leu Glu Leu Glu  Met Lys Xaa Leu Ser  Pro Gln Pro 
    1835                 1840                 1845             


His Ser  Pro Leu Gly Ser Pro  Phe Leu Trp Pro Gly  Val Glu Gly 
    1850                 1855                 1860             


Pro Asp  Ser Pro Asp Ser Pro  Lys Pro Gly Ala Leu  His Pro Ala 
    1865                 1870                 1875             


Ala His  Ala Arg Ser Ala Ser  His Phe Ser Leu Glu  His Pro Xaa 
    1880                 1885                 1890             


Met Gln  Pro His Pro Xaa Glu  Leu Pro Gly Pro Asp  Leu Leu Xaa 
    1895                 1900                 1905             


Val Arg  Lys Ser Gly Val Ser  Arg Xaa His Ser Leu  Pro Asn Asp 
    1910                 1915                 1920             


Ser Tyr  Met Cys Arg His Gly  Ser Xaa Ala Glu Gly  Pro Leu Gly 
    1925                 1930                 1935             


His Arg  Gly Trp Gly Leu Pro  Lys Ala Gln Ser Gly  Ser Val Leu 
    1940                 1945                 1950             


Ser Val  His Ser Gln Pro Ala  Asp Xaa Ser Tyr Ile  Leu Gln Leu 
    1955                 1960                 1965             


Pro Lys  Asp Ala Pro His Leu  Leu Gln Pro His Ser  Ala Pro Xaa 
    1970                 1975                 1980             


Trp Gly  Xaa Ile Pro Lys Leu  Pro Pro Pro Gly Arg  Ser Pro Leu 
    1985                 1990                 1995             


Ala Gln  Arg Pro Leu Arg Arg  Gln Ala Ala Ile Arg  Xaa Asp Ser 
    2000                 2005                 2010             


Leu Asp  Val Gln Gly Leu Gly  Ser Arg Glu Asp Leu  Leu Ala Glu 
    2015                 2020                 2025             


Glu Glu  Pro Pro Ser Pro Arg  Asp Leu Lys Lys Cys  Tyr Ser Val 
    2030                 2035                 2040             


Glu Ala  Gln Ser Cys Gln Arg  Arg Pro Xaa Ser Trp  Leu Asp Glu 
    2045                 2050                 2055             


Gln Arg  Arg His Ser Ile Ala  Val Ser Cys Leu Asp  Ser Gly Ser 
    2060                 2065                 2070             


Gln Pro  His Leu Gly Xaa Asp  Pro Ser Asn Leu Gly  Gly Gln Pro 
    2075                 2080                 2085             


Leu Gly  Gly Pro Gly Ser Arg  Pro Lys Lys Lys Leu  Ser Pro Pro 
    2090                 2095                 2100             


Ser Ile  Xaa Ile Asp Pro Pro  Glu Ser Gln Gly Pro  Arg Xaa Pro 
    2105                 2110                 2115             


Pro Ser  Pro Gly Ile Cys Leu  Arg Arg Arg Ala Pro  Ser Ser Asp 
    2120                 2125                 2130             


Ser Lys  Asp Pro Leu Ala Ser  Gly Pro Pro Asp Ser  Met Ala Ala 
    2135                 2140                 2145             


Ser Pro  Ser Pro Lys Lys Asp  Val Leu Ser Leu Ser  Gly Leu Ser 
    2150                 2155                 2160             


Ser Asp  Pro Ala Asp Leu Asp  Pro 
    2165                 2170     


<210> 4704
<211> 2194
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1598)..(1598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1616)..(1616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1680)..(1680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1695)..(1695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1724)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1762)..(1762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1783)..(1783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1789)..(1789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1800)..(1800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1809)..(1809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1813)..(1813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1826)..(1826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1866)..(1866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1916)..(1916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1922)..(1922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1931)..(1931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1940)..(1940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1955)..(1955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1985)..(1985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2006)..(2006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2009)..(2009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2034)..(2034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2076)..(2076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2102)..(2102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2129)..(2129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2140)..(2140)
<223> Selenocysteine

<400> 4704
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Pro  Ile Met Asn His Asn  Pro Trp Met Leu Leu  Tyr Phe Ile 
    1505                 1510                 1515             


Ser Phe  Leu Leu Ile Val Ala  Phe Phe Val Leu Asn  Met Phe Val 
    1520                 1525                 1530             


Gly Val  Val Val Glu Asn Phe  His Lys Cys Arg Gln  His Gln Glu 
    1535                 1540                 1545             


Glu Glu  Glu Ala Arg Arg Arg  Glu Glu Lys Arg Leu  Arg Arg Leu 
    1550                 1555                 1560             


Glu Lys  Lys Arg Arg Ser Lys  Glu Lys Gln Met Ala  Glu Ala Gln 
    1565                 1570                 1575             


Cys Lys  Pro Tyr Tyr Ser Asp  Tyr Ser Arg Phe Arg  Leu Leu Val 
    1580                 1585                 1590             


His His  Leu Cys Xaa Ser His  Tyr Leu Asp Leu Phe  Ile Xaa Gly 
    1595                 1600                 1605             


Val Ile  Gly Leu Asn Val Val  Xaa Met Ala Met Glu  His Tyr Gln 
    1610                 1615                 1620             


Gln Pro  Gln Ile Leu Asp Glu  Ala Leu Lys Ile Cys  Asn Tyr Ile 
    1625                 1630                 1635             


Phe Xaa  Val Ile Phe Val Leu  Glu Ser Val Phe Lys  Leu Val Ala 
    1640                 1645                 1650             


Phe Gly  Phe Arg Arg Phe Phe  Gln Asp Arg Trp Asn  Gln Leu Asp 
    1655                 1660                 1665             


Leu Ala  Ile Val Leu Leu Ser  Ile Met Gly Ile Xaa  Leu Glu Glu 
    1670                 1675                 1680             


Ile Glu  Val Asn Ala Ser Leu  Pro Ile Asn Pro Xaa  Ile Ile Arg 
    1685                 1690                 1695             


Ile Met  Arg Val Leu Arg Ile  Ala Arg Val Leu Lys  Leu Leu Lys 
    1700                 1705                 1710             


Met Ala  Val Gly Met Arg Ala  Leu Leu Asp Xaa Val  Met Gln Ala 
    1715                 1720                 1725             


Leu Pro  Gln Val Gly Asn Leu  Gly Leu Leu Phe Met  Leu Leu Phe 
    1730                 1735                 1740             


Phe Ile  Phe Ala Ala Leu Gly  Val Glu Leu Phe Gly  Asp Leu Glu 
    1745                 1750                 1755             


Cys Asp  Glu Xaa His Pro Cys  Glu Gly Leu Gly Arg  His Ala Xaa 
    1760                 1765                 1770             


Phe Arg  Asn Phe Gly Met Ala  Phe Leu Xaa Leu Phe  Arg Val Ser 
    1775                 1780                 1785             


Xaa Gly  Asp Asn Trp Asn Gly  Ile Met Lys Asp Xaa  Leu Arg Asp 
    1790                 1795                 1800             


Cys Asp  Gln Glu Ser Xaa Cys  Tyr Asn Xaa Val Ile  Ser Pro Ile 
    1805                 1810                 1815             


Tyr Phe  Val Ser Phe Val Leu  Xaa Ala Gln Phe Val  Leu Val Asn 
    1820                 1825                 1830             


Val Val  Ile Ala Val Leu Met  Lys His Leu Glu Glu  Ser Asn Lys 
    1835                 1840                 1845             


Glu Ala  Lys Glu Glu Ala Glu  Leu Glu Ala Glu Leu  Glu Leu Glu 
    1850                 1855                 1860             


Met Lys  Xaa Leu Ser Pro Gln  Pro His Ser Pro Leu  Gly Ser Pro 
    1865                 1870                 1875             


Phe Leu  Trp Pro Gly Val Glu  Gly Pro Asp Ser Pro  Asp Ser Pro 
    1880                 1885                 1890             


Lys Pro  Gly Ala Leu His Pro  Ala Ala His Ala Arg  Ser Ala Ser 
    1895                 1900                 1905             


His Phe  Ser Leu Glu His Pro  Xaa Met Gln Pro His  Pro Xaa Glu 
    1910                 1915                 1920             


Leu Pro  Gly Pro Asp Leu Leu  Xaa Val Arg Lys Ser  Gly Val Ser 
    1925                 1930                 1935             


Arg Xaa  His Ser Leu Pro Asn  Asp Ser Tyr Met Cys  Arg His Gly 
    1940                 1945                 1950             


Ser Xaa  Ala Glu Gly Pro Leu  Gly His Arg Gly Trp  Gly Leu Pro 
    1955                 1960                 1965             


Lys Ala  Gln Ser Gly Ser Val  Leu Ser Val His Ser  Gln Pro Ala 
    1970                 1975                 1980             


Asp Xaa  Ser Tyr Ile Leu Gln  Leu Pro Lys Asp Ala  Pro His Leu 
    1985                 1990                 1995             


Leu Gln  Pro His Ser Ala Pro  Xaa Trp Gly Xaa Ile  Pro Lys Leu 
    2000                 2005                 2010             


Pro Pro  Pro Gly Arg Ser Pro  Leu Ala Gln Arg Pro  Leu Arg Arg 
    2015                 2020                 2025             


Gln Ala  Ala Ile Arg Xaa Asp  Ser Leu Asp Val Gln  Gly Leu Gly 
    2030                 2035                 2040             


Ser Arg  Glu Asp Leu Leu Ala  Glu Glu Glu Pro Pro  Ser Pro Arg 
    2045                 2050                 2055             


Asp Leu  Lys Lys Cys Tyr Ser  Val Glu Ala Gln Ser  Cys Gln Arg 
    2060                 2065                 2070             


Arg Pro  Xaa Ser Trp Leu Asp  Glu Gln Arg Arg His  Ser Ile Ala 
    2075                 2080                 2085             


Val Ser  Cys Leu Asp Ser Gly  Ser Gln Pro His Leu  Gly Xaa Asp 
    2090                 2095                 2100             


Pro Ser  Asn Leu Gly Gly Gln  Pro Leu Gly Gly Pro  Gly Ser Arg 
    2105                 2110                 2115             


Pro Lys  Lys Lys Leu Ser Pro  Pro Ser Ile Xaa Ile  Asp Pro Pro 
    2120                 2125                 2130             


Glu Ser  Gln Gly Pro Arg Xaa  Pro Pro Ser Pro Gly  Ile Cys Leu 
    2135                 2140                 2145             


Arg Arg  Arg Ala Pro Ser Ser  Asp Ser Lys Asp Pro  Leu Ala Ser 
    2150                 2155                 2160             


Gly Pro  Pro Asp Ser Met Ala  Ala Ser Pro Ser Pro  Lys Lys Asp 
    2165                 2170                 2175             


Val Leu  Ser Leu Ser Gly Leu  Ser Ser Asp Pro Ala  Asp Leu Asp 
    2180                 2185                 2190             


Pro 
    


<210> 4705
<211> 2205
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1618)..(1618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1627)..(1627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1651)..(1651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1691)..(1691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1706)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1735)..(1735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1784)..(1784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1794)..(1794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1800)..(1800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1811)..(1811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1820)..(1820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1824)..(1824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1837)..(1837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1877)..(1877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1927)..(1927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1933)..(1933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1942)..(1942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1951)..(1951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1966)..(1966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1996)..(1996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2017)..(2017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2020)..(2020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2045)..(2045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2087)..(2087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2113)..(2113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2140)..(2140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2151)..(2151)
<223> Selenocysteine

<400> 4705
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Pro  Ile Met Asn His Asn  Pro Trp Met Leu Leu  Tyr Phe Ile 
    1505                 1510                 1515             


Ser Phe  Leu Leu Ile Val Ala  Phe Phe Val Leu Asn  Met Phe Val 
    1520                 1525                 1530             


Gly Val  Val Val Glu Asn Phe  His Lys Cys Arg Gln  His Gln Glu 
    1535                 1540                 1545             


Glu Glu  Glu Ala Arg Arg Arg  Glu Glu Lys Arg Leu  Arg Arg Leu 
    1550                 1555                 1560             


Glu Lys  Lys Arg Arg Asn Leu  Met Leu Asp Asp Val  Ile Ala Ser 
    1565                 1570                 1575             


Gly Ser  Ser Ala Ser Ala Ala  Ser Glu Ala Gln Cys  Lys Pro Tyr 
    1580                 1585                 1590             


Tyr Ser  Asp Tyr Ser Arg Phe  Arg Leu Leu Val His  His Leu Cys 
    1595                 1600                 1605             


Xaa Ser  His Tyr Leu Asp Leu  Phe Ile Xaa Gly Val  Ile Gly Leu 
    1610                 1615                 1620             


Asn Val  Val Xaa Met Ala Met  Glu His Tyr Gln Gln  Pro Gln Ile 
    1625                 1630                 1635             


Leu Asp  Glu Ala Leu Lys Ile  Cys Asn Tyr Ile Phe  Xaa Val Ile 
    1640                 1645                 1650             


Phe Val  Leu Glu Ser Val Phe  Lys Leu Val Ala Phe  Gly Phe Arg 
    1655                 1660                 1665             


Arg Phe  Phe Gln Asp Arg Trp  Asn Gln Leu Asp Leu  Ala Ile Val 
    1670                 1675                 1680             


Leu Leu  Ser Ile Met Gly Ile  Xaa Leu Glu Glu Ile  Glu Val Asn 
    1685                 1690                 1695             


Ala Ser  Leu Pro Ile Asn Pro  Xaa Ile Ile Arg Ile  Met Arg Val 
    1700                 1705                 1710             


Leu Arg  Ile Ala Arg Val Leu  Lys Leu Leu Lys Met  Ala Val Gly 
    1715                 1720                 1725             


Met Arg  Ala Leu Leu Asp Xaa  Val Met Gln Ala Leu  Pro Gln Val 
    1730                 1735                 1740             


Gly Asn  Leu Gly Leu Leu Phe  Met Leu Leu Phe Phe  Ile Phe Ala 
    1745                 1750                 1755             


Ala Leu  Gly Val Glu Leu Phe  Gly Asp Leu Glu Cys  Asp Glu Xaa 
    1760                 1765                 1770             


His Pro  Cys Glu Gly Leu Gly  Arg His Ala Xaa Phe  Arg Asn Phe 
    1775                 1780                 1785             


Gly Met  Ala Phe Leu Xaa Leu  Phe Arg Val Ser Xaa  Gly Asp Asn 
    1790                 1795                 1800             


Trp Asn  Gly Ile Met Lys Asp  Xaa Leu Arg Asp Cys  Asp Gln Glu 
    1805                 1810                 1815             


Ser Xaa  Cys Tyr Asn Xaa Val  Ile Ser Pro Ile Tyr  Phe Val Ser 
    1820                 1825                 1830             


Phe Val  Leu Xaa Ala Gln Phe  Val Leu Val Asn Val  Val Ile Ala 
    1835                 1840                 1845             


Val Leu  Met Lys His Leu Glu  Glu Ser Asn Lys Glu  Ala Lys Glu 
    1850                 1855                 1860             


Glu Ala  Glu Leu Glu Ala Glu  Leu Glu Leu Glu Met  Lys Xaa Leu 
    1865                 1870                 1875             


Ser Pro  Gln Pro His Ser Pro  Leu Gly Ser Pro Phe  Leu Trp Pro 
    1880                 1885                 1890             


Gly Val  Glu Gly Pro Asp Ser  Pro Asp Ser Pro Lys  Pro Gly Ala 
    1895                 1900                 1905             


Leu His  Pro Ala Ala His Ala  Arg Ser Ala Ser His  Phe Ser Leu 
    1910                 1915                 1920             


Glu His  Pro Xaa Met Gln Pro  His Pro Xaa Glu Leu  Pro Gly Pro 
    1925                 1930                 1935             


Asp Leu  Leu Xaa Val Arg Lys  Ser Gly Val Ser Arg  Xaa His Ser 
    1940                 1945                 1950             


Leu Pro  Asn Asp Ser Tyr Met  Cys Arg His Gly Ser  Xaa Ala Glu 
    1955                 1960                 1965             


Gly Pro  Leu Gly His Arg Gly  Trp Gly Leu Pro Lys  Ala Gln Ser 
    1970                 1975                 1980             


Gly Ser  Val Leu Ser Val His  Ser Gln Pro Ala Asp  Xaa Ser Tyr 
    1985                 1990                 1995             


Ile Leu  Gln Leu Pro Lys Asp  Ala Pro His Leu Leu  Gln Pro His 
    2000                 2005                 2010             


Ser Ala  Pro Xaa Trp Gly Xaa  Ile Pro Lys Leu Pro  Pro Pro Gly 
    2015                 2020                 2025             


Arg Ser  Pro Leu Ala Gln Arg  Pro Leu Arg Arg Gln  Ala Ala Ile 
    2030                 2035                 2040             


Arg Xaa  Asp Ser Leu Asp Val  Gln Gly Leu Gly Ser  Arg Glu Asp 
    2045                 2050                 2055             


Leu Leu  Ala Glu Glu Glu Pro  Pro Ser Pro Arg Asp  Leu Lys Lys 
    2060                 2065                 2070             


Cys Tyr  Ser Val Glu Ala Gln  Ser Cys Gln Arg Arg  Pro Xaa Ser 
    2075                 2080                 2085             


Trp Leu  Asp Glu Gln Arg Arg  His Ser Ile Ala Val  Ser Cys Leu 
    2090                 2095                 2100             


Asp Ser  Gly Ser Gln Pro His  Leu Gly Xaa Asp Pro  Ser Asn Leu 
    2105                 2110                 2115             


Gly Gly  Gln Pro Leu Gly Gly  Pro Gly Ser Arg Pro  Lys Lys Lys 
    2120                 2125                 2130             


Leu Ser  Pro Pro Ser Ile Xaa  Ile Asp Pro Pro Glu  Ser Gln Gly 
    2135                 2140                 2145             


Pro Arg  Xaa Pro Pro Ser Pro  Gly Ile Cys Leu Arg  Arg Arg Ala 
    2150                 2155                 2160             


Pro Ser  Ser Asp Ser Lys Asp  Pro Leu Ala Ser Gly  Pro Pro Asp 
    2165                 2170                 2175             


Ser Met  Ala Ala Ser Pro Ser  Pro Lys Lys Asp Val  Leu Ser Leu 
    2180                 2185                 2190             


Ser Gly  Leu Ser Ser Asp Pro  Ala Asp Leu Asp Pro  
    2195                 2200                 2205 


<210> 4706
<211> 2227
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1552)..(1552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1561)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1570)..(1570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1634)..(1634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1649)..(1649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1678)..(1678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1716)..(1716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1727)..(1727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1737)..(1737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1743)..(1743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1763)..(1763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1767)..(1767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1780)..(1780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1820)..(1820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1870)..(1870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1876)..(1876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1885)..(1885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1894)..(1894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1909)..(1909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1939)..(1939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1960)..(1960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1963)..(1963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1988)..(1988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2025)..(2025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2042)..(2042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2061)..(2061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2069)..(2069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2109)..(2109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2135)..(2135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2162)..(2162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2173)..(2173)
<223> Selenocysteine

<400> 4706
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Gly Asp Ala Asn Lys Ser 
                965                 970                 975     


Glu Ser Glu Pro Asp Phe Phe Ser Pro Ser Leu Asp Gly Asp Gly Asp 
            980                 985                 990         


Arg Lys Lys Cys Leu Ala Leu Val  Ser Leu Gly Glu His  Pro Glu Leu 
        995                 1000                 1005             


Arg Lys  Ser Leu Leu Pro Pro  Leu Ile Ile His Xaa  Ala Ala Xaa 
    1010                 1015                 1020             


Pro Met  Ser Leu Pro Lys Ser  Xaa Ser Xaa Gly Leu  Gly Glu Ala 
    1025                 1030                 1035             


Leu Gly  Pro Ala Ser Arg Arg  Xaa Ser Ser Ser Gly  Ser Ala Glu 
    1040                 1045                 1050             


Pro Gly  Ala Ala His Glu Met  Lys Ser Pro Pro Ser  Ala Arg Ser 
    1055                 1060                 1065             


Ser Pro  His Ser Pro Trp Ser  Ala Ala Ser Ser Trp  Xaa Ser Arg 
    1070                 1075                 1080             


Arg Ser  Ser Arg Asn Ser Leu  Gly Arg Ala Pro Ser  Leu Lys Arg 
    1085                 1090                 1095             


Arg Ser  Pro Ser Gly Glu Arg  Arg Ser Leu Leu Ser  Gly Glu Gly 
    1100                 1105                 1110             


Gln Glu  Ser Gln Asp Glu Glu  Glu Ser Ser Glu Glu  Glu Arg Ala 
    1115                 1120                 1125             


Ser Pro  Ala Gly Ser Asp His  Arg His Arg Gly Ser  Leu Glu Arg 
    1130                 1135                 1140             


Glu Ala  Lys Ser Ser Phe Asp  Leu Pro Asp Xaa Leu  Gln Val Pro 
    1145                 1150                 1155             


Gly Leu  His Arg Xaa Ala Ser  Gly Arg Gly Ser Ala  Ser Glu His 
    1160                 1165                 1170             


Gln Asp  Cys Asn Gly Lys Ser  Ala Ser Gly Arg Leu  Ala Arg Ala 
    1175                 1180                 1185             


Leu Arg  Pro Asp Asp Pro Pro  Leu Asp Gly Asp Asp  Ala Asp Asp 
    1190                 1195                 1200             


Glu Gly  Asn Leu Ser Lys Gly  Glu Arg Val Arg Ala  Trp Ile Arg 
    1205                 1210                 1215             


Ala Arg  Leu Pro Ala Cys Cys  Leu Glu Arg Asp Ser  Trp Ser Ala 
    1220                 1225                 1230             


Tyr Ile  Phe Pro Pro Gln Ser  Arg Phe Arg Leu Leu  Cys His Arg 
    1235                 1240                 1245             


Ile Ile  Xaa His Lys Met Phe  Asp His Val Val Leu  Val Ile Ile 
    1250                 1255                 1260             


Phe Leu  Asn Cys Ile Xaa Ile  Ala Met Glu Arg Pro  Lys Ile Asp 
    1265                 1270                 1275             


Pro His  Ser Ala Glu Arg Ile  Phe Leu Xaa Leu Ser  Asn Tyr Ile 
    1280                 1285                 1290             


Phe Xaa  Ala Val Phe Leu Ala  Glu Met Xaa Val Lys  Val Val Ala 
    1295                 1300                 1305             


Leu Gly  Trp Cys Phe Gly Glu  Gln Ala Tyr Leu Arg  Ser Ser Trp 
    1310                 1315                 1320             


Asn Val  Leu Asp Gly Leu Leu  Val Leu Ile Ser Val  Ile Asp Ile 
    1325                 1330                 1335             


Leu Val  Ser Met Val Ser Asp  Ser Gly Xaa Lys Ile  Leu Gly Met 
    1340                 1345                 1350             


Leu Arg  Val Leu Arg Leu Leu  Arg Xaa Leu Arg Pro  Leu Arg Val 
    1355                 1360                 1365             


Ile Ser  Arg Ala Gln Gly Leu  Lys Leu Val Val Glu  Xaa Leu Met 
    1370                 1375                 1380             


Ser Ser  Leu Lys Pro Ile Gly  Asn Ile Val Val Ile  Cys Cys Ala 
    1385                 1390                 1395             


Phe Phe  Ile Ile Phe Gly Ile  Leu Gly Val Gln Leu  Phe Lys Gly 
    1400                 1405                 1410             


Lys Phe  Phe Val Cys Gln Gly  Glu Asp Xaa Arg Asn  Ile Xaa Asn 
    1415                 1420                 1425             


Lys Ser  Asp Cys Ala Glu Ala  Ser Tyr Arg Trp Val  Arg His Lys 
    1430                 1435                 1440             


Tyr Asn  Phe Asp Asn Leu Gly  Gln Ala Leu Met Ser  Leu Phe Val 
    1445                 1450                 1455             


Leu Ala  Ser Lys Asp Gly Trp  Val Asp Ile Met Tyr  Asp Gly Leu 
    1460                 1465                 1470             


Asp Ala  Val Gly Val Asp Gln  Gln Asn Phe His Lys  Cys Arg Gln 
    1475                 1480                 1485             


His Gln  Glu Glu Glu Glu Ala  Arg Arg Arg Glu Glu  Lys Arg Leu 
    1490                 1495                 1500             


Arg Arg  Leu Glu Lys Lys Arg  Arg Asn Leu Met Leu  Asp Asp Val 
    1505                 1510                 1515             


Ile Ala  Ser Gly Ser Ser Ala  Ser Ala Ala Ser Glu  Ala Gln Cys 
    1520                 1525                 1530             


Lys Pro  Tyr Tyr Ser Asp Tyr  Ser Arg Phe Arg Leu  Leu Val His 
    1535                 1540                 1545             


His Leu  Cys Xaa Ser His Tyr  Leu Asp Leu Phe Ile  Xaa Gly Val 
    1550                 1555                 1560             


Ile Gly  Leu Asn Val Val Xaa  Met Ala Met Glu His  Tyr Gln Gln 
    1565                 1570                 1575             


Pro Gln  Ile Leu Asp Glu Ala  Leu Lys Ile Cys Asn  Tyr Ile Phe 
    1580                 1585                 1590             


Xaa Val  Ile Phe Val Leu Glu  Ser Val Phe Lys Leu  Val Ala Phe 
    1595                 1600                 1605             


Gly Phe  Arg Arg Phe Phe Gln  Asp Arg Trp Asn Gln  Leu Asp Leu 
    1610                 1615                 1620             


Ala Ile  Val Leu Leu Ser Ile  Met Gly Ile Xaa Leu  Glu Glu Ile 
    1625                 1630                 1635             


Glu Val  Asn Ala Ser Leu Pro  Ile Asn Pro Xaa Ile  Ile Arg Ile 
    1640                 1645                 1650             


Met Arg  Val Leu Arg Ile Ala  Arg Val Leu Lys Leu  Leu Lys Met 
    1655                 1660                 1665             


Ala Val  Gly Met Arg Ala Leu  Leu Asp Xaa Val Met  Gln Ala Leu 
    1670                 1675                 1680             


Pro Gln  Val Gly Asn Leu Gly  Leu Leu Phe Met Leu  Leu Phe Phe 
    1685                 1690                 1695             


Ile Phe  Ala Ala Leu Gly Val  Glu Leu Phe Gly Asp  Leu Glu Cys 
    1700                 1705                 1710             


Asp Glu  Xaa His Pro Cys Glu  Gly Leu Gly Arg His  Ala Xaa Phe 
    1715                 1720                 1725             


Arg Asn  Phe Gly Met Ala Phe  Leu Xaa Leu Phe Arg  Val Ser Xaa 
    1730                 1735                 1740             


Gly Asp  Asn Trp Asn Gly Ile  Met Lys Asp Xaa Leu  Arg Asp Cys 
    1745                 1750                 1755             


Asp Gln  Glu Ser Xaa Cys Tyr  Asn Xaa Val Ile Ser  Pro Ile Tyr 
    1760                 1765                 1770             


Phe Val  Ser Phe Val Leu Xaa  Ala Gln Phe Val Leu  Val Asn Val 
    1775                 1780                 1785             


Val Ile  Ala Val Leu Met Lys  His Leu Glu Glu Ser  Asn Lys Glu 
    1790                 1795                 1800             


Ala Lys  Glu Glu Ala Glu Leu  Glu Ala Glu Leu Glu  Leu Glu Met 
    1805                 1810                 1815             


Lys Xaa  Leu Ser Pro Gln Pro  His Ser Pro Leu Gly  Ser Pro Phe 
    1820                 1825                 1830             


Leu Trp  Pro Gly Val Glu Gly  Pro Asp Ser Pro Asp  Ser Pro Lys 
    1835                 1840                 1845             


Pro Gly  Ala Leu His Pro Ala  Ala His Ala Arg Ser  Ala Ser His 
    1850                 1855                 1860             


Phe Ser  Leu Glu His Pro Xaa  Met Gln Pro His Pro  Xaa Glu Leu 
    1865                 1870                 1875             


Pro Gly  Pro Asp Leu Leu Xaa  Val Arg Lys Ser Gly  Val Ser Arg 
    1880                 1885                 1890             


Xaa His  Ser Leu Pro Asn Asp  Ser Tyr Met Cys Arg  His Gly Ser 
    1895                 1900                 1905             


Xaa Ala  Glu Gly Pro Leu Gly  His Arg Gly Trp Gly  Leu Pro Lys 
    1910                 1915                 1920             


Ala Gln  Ser Gly Ser Val Leu  Ser Val His Ser Gln  Pro Ala Asp 
    1925                 1930                 1935             


Xaa Ser  Tyr Ile Leu Gln Leu  Pro Lys Asp Ala Pro  His Leu Leu 
    1940                 1945                 1950             


Gln Pro  His Ser Ala Pro Xaa  Trp Gly Xaa Ile Pro  Lys Leu Pro 
    1955                 1960                 1965             


Pro Pro  Gly Arg Ser Pro Leu  Ala Gln Arg Pro Leu  Arg Arg Gln 
    1970                 1975                 1980             


Ala Ala  Ile Arg Xaa Asp Ser  Leu Asp Val Gln Gly  Leu Gly Ser 
    1985                 1990                 1995             


Arg Glu  Asp Leu Leu Ala Glu  Val Ser Gly Pro Ser  Pro Pro Leu 
    2000                 2005                 2010             


Ala Arg  Ala Tyr Ser Phe Trp  Gly Gln Ser Ser Xaa  Gln Ala Gln 
    2015                 2020                 2025             


Gln His  Ser Arg Ser His Ser  Lys Ile Ser Lys His  Met Xaa Pro 
    2030                 2035                 2040             


Pro Ala  Pro Cys Pro Gly Pro  Glu Pro Asn Trp Gly  Lys Gly Pro 
    2045                 2050                 2055             


Pro Glu  Xaa Arg Ser Ser Leu  Glu Leu Asp Xaa Glu  Leu Ser Trp 
    2060                 2065                 2070             


Ile Ser  Gly Asp Leu Leu Pro  Pro Gly Gly Gln Glu  Glu Pro Pro 
    2075                 2080                 2085             


Ser Pro  Arg Asp Leu Lys Lys  Cys Tyr Ser Val Glu  Ala Gln Ser 
    2090                 2095                 2100             


Cys Gln  Arg Arg Pro Xaa Ser  Trp Leu Asp Glu Gln  Arg Arg His 
    2105                 2110                 2115             


Ser Ile  Ala Val Ser Cys Leu  Asp Ser Gly Ser Gln  Pro His Leu 
    2120                 2125                 2130             


Gly Xaa  Asp Pro Ser Asn Leu  Gly Gly Gln Pro Leu  Gly Gly Pro 
    2135                 2140                 2145             


Gly Ser  Arg Pro Lys Lys Lys  Leu Ser Pro Pro Ser  Ile Xaa Ile 
    2150                 2155                 2160             


Asp Pro  Pro Glu Ser Gln Gly  Pro Arg Xaa Pro Pro  Ser Pro Gly 
    2165                 2170                 2175             


Ile Cys  Leu Arg Arg Arg Ala  Pro Ser Ser Asp Ser  Lys Asp Pro 
    2180                 2185                 2190             


Leu Ala  Ser Gly Pro Pro Asp  Ser Met Ala Ala Ser  Pro Ser Pro 
    2195                 2200                 2205             


Lys Lys  Asp Val Leu Ser Leu  Ser Gly Leu Ser Ser  Asp Pro Ala 
    2210                 2215                 2220             


Asp Leu  Asp Pro 
    2225         


<210> 4707
<211> 2232
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1557)..(1557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1566)..(1566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1575)..(1575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1599)..(1599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1639)..(1639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1654)..(1654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1683)..(1683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1732)..(1732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1742)..(1742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1748)..(1748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1759)..(1759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1768)..(1768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1772)..(1772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1785)..(1785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1825)..(1825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1875)..(1875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1881)..(1881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1890)..(1890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1899)..(1899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1914)..(1914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1944)..(1944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1965)..(1965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1968)..(1968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1993)..(1993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2030)..(2030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2047)..(2047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2066)..(2066)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2074)..(2074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2114)..(2114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2140)..(2140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2167)..(2167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2178)..(2178)
<223> Selenocysteine

<400> 4707
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Asn  Phe His Lys Cys Arg  Gln His Gln Glu Glu  Glu Glu Ala 
    1505                 1510                 1515             


Arg Arg  Arg Glu Glu Lys Arg  Leu Arg Arg Leu Glu  Lys Lys Arg 
    1520                 1525                 1530             


Arg Lys  Ala Gln Cys Lys Pro  Tyr Tyr Ser Asp Tyr  Ser Arg Phe 
    1535                 1540                 1545             


Arg Leu  Leu Val His His Leu  Cys Xaa Ser His Tyr  Leu Asp Leu 
    1550                 1555                 1560             


Phe Ile  Xaa Gly Val Ile Gly  Leu Asn Val Val Xaa  Met Ala Met 
    1565                 1570                 1575             


Glu His  Tyr Gln Gln Pro Gln  Ile Leu Asp Glu Ala  Leu Lys Ile 
    1580                 1585                 1590             


Cys Asn  Tyr Ile Phe Xaa Val  Ile Phe Val Leu Glu  Ser Val Phe 
    1595                 1600                 1605             


Lys Leu  Val Ala Phe Gly Phe  Arg Arg Phe Phe Gln  Asp Arg Trp 
    1610                 1615                 1620             


Asn Gln  Leu Asp Leu Ala Ile  Val Leu Leu Ser Ile  Met Gly Ile 
    1625                 1630                 1635             


Xaa Leu  Glu Glu Ile Glu Val  Asn Ala Ser Leu Pro  Ile Asn Pro 
    1640                 1645                 1650             


Xaa Ile  Ile Arg Ile Met Arg  Val Leu Arg Ile Ala  Arg Val Leu 
    1655                 1660                 1665             


Lys Leu  Leu Lys Met Ala Val  Gly Met Arg Ala Leu  Leu Asp Xaa 
    1670                 1675                 1680             


Val Met  Gln Ala Leu Pro Gln  Val Gly Asn Leu Gly  Leu Leu Phe 
    1685                 1690                 1695             


Met Leu  Leu Phe Phe Ile Phe  Ala Ala Leu Gly Val  Glu Leu Phe 
    1700                 1705                 1710             


Gly Asp  Leu Glu Cys Asp Glu  Xaa His Pro Cys Glu  Gly Leu Gly 
    1715                 1720                 1725             


Arg His  Ala Xaa Phe Arg Asn  Phe Gly Met Ala Phe  Leu Xaa Leu 
    1730                 1735                 1740             


Phe Arg  Val Ser Xaa Gly Asp  Asn Trp Asn Gly Ile  Met Lys Asp 
    1745                 1750                 1755             


Xaa Leu  Arg Asp Cys Asp Gln  Glu Ser Xaa Cys Tyr  Asn Xaa Val 
    1760                 1765                 1770             


Ile Ser  Pro Ile Tyr Phe Val  Ser Phe Val Leu Xaa  Ala Gln Phe 
    1775                 1780                 1785             


Val Leu  Val Asn Val Val Ile  Ala Val Leu Met Lys  His Leu Glu 
    1790                 1795                 1800             


Glu Ser  Asn Lys Glu Ala Lys  Glu Glu Ala Glu Leu  Glu Ala Glu 
    1805                 1810                 1815             


Leu Glu  Leu Glu Met Lys Xaa  Leu Ser Pro Gln Pro  His Ser Pro 
    1820                 1825                 1830             


Leu Gly  Ser Pro Phe Leu Trp  Pro Gly Val Glu Gly  Pro Asp Ser 
    1835                 1840                 1845             


Pro Asp  Ser Pro Lys Pro Gly  Ala Leu His Pro Ala  Ala His Ala 
    1850                 1855                 1860             


Arg Ser  Ala Ser His Phe Ser  Leu Glu His Pro Xaa  Met Gln Pro 
    1865                 1870                 1875             


His Pro  Xaa Glu Leu Pro Gly  Pro Asp Leu Leu Xaa  Val Arg Lys 
    1880                 1885                 1890             


Ser Gly  Val Ser Arg Xaa His  Ser Leu Pro Asn Asp  Ser Tyr Met 
    1895                 1900                 1905             


Cys Arg  His Gly Ser Xaa Ala  Glu Gly Pro Leu Gly  His Arg Gly 
    1910                 1915                 1920             


Trp Gly  Leu Pro Lys Ala Gln  Ser Gly Ser Val Leu  Ser Val His 
    1925                 1930                 1935             


Ser Gln  Pro Ala Asp Xaa Ser  Tyr Ile Leu Gln Leu  Pro Lys Asp 
    1940                 1945                 1950             


Ala Pro  His Leu Leu Gln Pro  His Ser Ala Pro Xaa  Trp Gly Xaa 
    1955                 1960                 1965             


Ile Pro  Lys Leu Pro Pro Pro  Gly Arg Ser Pro Leu  Ala Gln Arg 
    1970                 1975                 1980             


Pro Leu  Arg Arg Gln Ala Ala  Ile Arg Xaa Asp Ser  Leu Asp Val 
    1985                 1990                 1995             


Gln Gly  Leu Gly Ser Arg Glu  Asp Leu Leu Ala Glu  Val Ser Gly 
    2000                 2005                 2010             


Pro Ser  Pro Pro Leu Ala Arg  Ala Tyr Ser Phe Trp  Gly Gln Ser 
    2015                 2020                 2025             


Ser Xaa  Gln Ala Gln Gln His  Ser Arg Ser His Ser  Lys Ile Ser 
    2030                 2035                 2040             


Lys His  Met Xaa Pro Pro Ala  Pro Cys Pro Gly Pro  Glu Pro Asn 
    2045                 2050                 2055             


Trp Gly  Lys Gly Pro Pro Glu  Xaa Arg Ser Ser Leu  Glu Leu Asp 
    2060                 2065                 2070             


Xaa Glu  Leu Ser Trp Ile Ser  Gly Asp Leu Leu Pro  Pro Gly Gly 
    2075                 2080                 2085             


Gln Glu  Glu Pro Pro Ser Pro  Arg Asp Leu Lys Lys  Cys Tyr Ser 
    2090                 2095                 2100             


Val Glu  Ala Gln Ser Cys Gln  Arg Arg Pro Xaa Ser  Trp Leu Asp 
    2105                 2110                 2115             


Glu Gln  Arg Arg His Ser Ile  Ala Val Ser Cys Leu  Asp Ser Gly 
    2120                 2125                 2130             


Ser Gln  Pro His Leu Gly Xaa  Asp Pro Ser Asn Leu  Gly Gly Gln 
    2135                 2140                 2145             


Pro Leu  Gly Gly Pro Gly Ser  Arg Pro Lys Lys Lys  Leu Ser Pro 
    2150                 2155                 2160             


Pro Ser  Ile Xaa Ile Asp Pro  Pro Glu Ser Gln Gly  Pro Arg Xaa 
    2165                 2170                 2175             


Pro Pro  Ser Pro Gly Ile Cys  Leu Arg Arg Arg Ala  Pro Ser Ser 
    2180                 2185                 2190             


Asp Ser  Lys Asp Pro Leu Ala  Ser Gly Pro Pro Asp  Ser Met Ala 
    2195                 2200                 2205             


Ala Ser  Pro Ser Pro Lys Lys  Asp Val Leu Ser Leu  Ser Gly Leu 
    2210                 2215                 2220             


Ser Ser  Asp Pro Ala Asp Leu  Asp Pro 
    2225                 2230         


<210> 4708
<211> 2239
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1564)..(1564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1661)..(1661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1690)..(1690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1728)..(1728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1739)..(1739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1749)..(1749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1755)..(1755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1766)..(1766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1775)..(1775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1779)..(1779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1792)..(1792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1832)..(1832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1882)..(1882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1888)..(1888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1897)..(1897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1906)..(1906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1921)..(1921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1951)..(1951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1972)..(1972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1975)..(1975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2000)..(2000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2037)..(2037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2054)..(2054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2073)..(2073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2081)..(2081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2121)..(2121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2147)..(2147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2174)..(2174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2185)..(2185)
<223> Selenocysteine

<400> 4708
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Asn  Phe His Lys Cys Arg  Gln His Gln Glu Glu  Glu Glu Ala 
    1505                 1510                 1515             


Arg Arg  Arg Glu Glu Lys Arg  Leu Arg Arg Leu Glu  Lys Lys Arg 
    1520                 1525                 1530             


Arg Ser  Lys Glu Lys Gln Met  Ala Glu Ala Gln Cys  Lys Pro Tyr 
    1535                 1540                 1545             


Tyr Ser  Asp Tyr Ser Arg Phe  Arg Leu Leu Val His  His Leu Cys 
    1550                 1555                 1560             


Xaa Ser  His Tyr Leu Asp Leu  Phe Ile Xaa Gly Val  Ile Gly Leu 
    1565                 1570                 1575             


Asn Val  Val Xaa Met Ala Met  Glu His Tyr Gln Gln  Pro Gln Ile 
    1580                 1585                 1590             


Leu Asp  Glu Ala Leu Lys Ile  Cys Asn Tyr Ile Phe  Xaa Val Ile 
    1595                 1600                 1605             


Phe Val  Leu Glu Ser Val Phe  Lys Leu Val Ala Phe  Gly Phe Arg 
    1610                 1615                 1620             


Arg Phe  Phe Gln Asp Arg Trp  Asn Gln Leu Asp Leu  Ala Ile Val 
    1625                 1630                 1635             


Leu Leu  Ser Ile Met Gly Ile  Xaa Leu Glu Glu Ile  Glu Val Asn 
    1640                 1645                 1650             


Ala Ser  Leu Pro Ile Asn Pro  Xaa Ile Ile Arg Ile  Met Arg Val 
    1655                 1660                 1665             


Leu Arg  Ile Ala Arg Val Leu  Lys Leu Leu Lys Met  Ala Val Gly 
    1670                 1675                 1680             


Met Arg  Ala Leu Leu Asp Xaa  Val Met Gln Ala Leu  Pro Gln Val 
    1685                 1690                 1695             


Gly Asn  Leu Gly Leu Leu Phe  Met Leu Leu Phe Phe  Ile Phe Ala 
    1700                 1705                 1710             


Ala Leu  Gly Val Glu Leu Phe  Gly Asp Leu Glu Cys  Asp Glu Xaa 
    1715                 1720                 1725             


His Pro  Cys Glu Gly Leu Gly  Arg His Ala Xaa Phe  Arg Asn Phe 
    1730                 1735                 1740             


Gly Met  Ala Phe Leu Xaa Leu  Phe Arg Val Ser Xaa  Gly Asp Asn 
    1745                 1750                 1755             


Trp Asn  Gly Ile Met Lys Asp  Xaa Leu Arg Asp Cys  Asp Gln Glu 
    1760                 1765                 1770             


Ser Xaa  Cys Tyr Asn Xaa Val  Ile Ser Pro Ile Tyr  Phe Val Ser 
    1775                 1780                 1785             


Phe Val  Leu Xaa Ala Gln Phe  Val Leu Val Asn Val  Val Ile Ala 
    1790                 1795                 1800             


Val Leu  Met Lys His Leu Glu  Glu Ser Asn Lys Glu  Ala Lys Glu 
    1805                 1810                 1815             


Glu Ala  Glu Leu Glu Ala Glu  Leu Glu Leu Glu Met  Lys Xaa Leu 
    1820                 1825                 1830             


Ser Pro  Gln Pro His Ser Pro  Leu Gly Ser Pro Phe  Leu Trp Pro 
    1835                 1840                 1845             


Gly Val  Glu Gly Pro Asp Ser  Pro Asp Ser Pro Lys  Pro Gly Ala 
    1850                 1855                 1860             


Leu His  Pro Ala Ala His Ala  Arg Ser Ala Ser His  Phe Ser Leu 
    1865                 1870                 1875             


Glu His  Pro Xaa Met Gln Pro  His Pro Xaa Glu Leu  Pro Gly Pro 
    1880                 1885                 1890             


Asp Leu  Leu Xaa Val Arg Lys  Ser Gly Val Ser Arg  Xaa His Ser 
    1895                 1900                 1905             


Leu Pro  Asn Asp Ser Tyr Met  Cys Arg His Gly Ser  Xaa Ala Glu 
    1910                 1915                 1920             


Gly Pro  Leu Gly His Arg Gly  Trp Gly Leu Pro Lys  Ala Gln Ser 
    1925                 1930                 1935             


Gly Ser  Val Leu Ser Val His  Ser Gln Pro Ala Asp  Xaa Ser Tyr 
    1940                 1945                 1950             


Ile Leu  Gln Leu Pro Lys Asp  Ala Pro His Leu Leu  Gln Pro His 
    1955                 1960                 1965             


Ser Ala  Pro Xaa Trp Gly Xaa  Ile Pro Lys Leu Pro  Pro Pro Gly 
    1970                 1975                 1980             


Arg Ser  Pro Leu Ala Gln Arg  Pro Leu Arg Arg Gln  Ala Ala Ile 
    1985                 1990                 1995             


Arg Xaa  Asp Ser Leu Asp Val  Gln Gly Leu Gly Ser  Arg Glu Asp 
    2000                 2005                 2010             


Leu Leu  Ala Glu Val Ser Gly  Pro Ser Pro Pro Leu  Ala Arg Ala 
    2015                 2020                 2025             


Tyr Ser  Phe Trp Gly Gln Ser  Ser Xaa Gln Ala Gln  Gln His Ser 
    2030                 2035                 2040             


Arg Ser  His Ser Lys Ile Ser  Lys His Met Xaa Pro  Pro Ala Pro 
    2045                 2050                 2055             


Cys Pro  Gly Pro Glu Pro Asn  Trp Gly Lys Gly Pro  Pro Glu Xaa 
    2060                 2065                 2070             


Arg Ser  Ser Leu Glu Leu Asp  Xaa Glu Leu Ser Trp  Ile Ser Gly 
    2075                 2080                 2085             


Asp Leu  Leu Pro Pro Gly Gly  Gln Glu Glu Pro Pro  Ser Pro Arg 
    2090                 2095                 2100             


Asp Leu  Lys Lys Cys Tyr Ser  Val Glu Ala Gln Ser  Cys Gln Arg 
    2105                 2110                 2115             


Arg Pro  Xaa Ser Trp Leu Asp  Glu Gln Arg Arg His  Ser Ile Ala 
    2120                 2125                 2130             


Val Ser  Cys Leu Asp Ser Gly  Ser Gln Pro His Leu  Gly Xaa Asp 
    2135                 2140                 2145             


Pro Ser  Asn Leu Gly Gly Gln  Pro Leu Gly Gly Pro  Gly Ser Arg 
    2150                 2155                 2160             


Pro Lys  Lys Lys Leu Ser Pro  Pro Ser Ile Xaa Ile  Asp Pro Pro 
    2165                 2170                 2175             


Glu Ser  Gln Gly Pro Arg Xaa  Pro Pro Ser Pro Gly  Ile Cys Leu 
    2180                 2185                 2190             


Arg Arg  Arg Ala Pro Ser Ser  Asp Ser Lys Asp Pro  Leu Ala Ser 
    2195                 2200                 2205             


Gly Pro  Pro Asp Ser Met Ala  Ala Ser Pro Ser Pro  Lys Lys Asp 
    2210                 2215                 2220             


Val Leu  Ser Leu Ser Gly Leu  Ser Ser Asp Pro Ala  Asp Leu Asp 
    2225                 2230                 2235             


Pro 
    


<210> 4709
<211> 2243
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1577)..(1577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1610)..(1610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1650)..(1650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1665)..(1665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1694)..(1694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1732)..(1732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1743)..(1743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1753)..(1753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1759)..(1759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1770)..(1770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1779)..(1779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1783)..(1783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1796)..(1796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1836)..(1836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1886)..(1886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1892)..(1892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1901)..(1901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1910)..(1910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1925)..(1925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1955)..(1955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1976)..(1976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1979)..(1979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2004)..(2004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2041)..(2041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2058)..(2058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2077)..(2077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2085)..(2085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2125)..(2125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2151)..(2151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2178)..(2178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2189)..(2189)
<223> Selenocysteine

<400> 4709
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Gly Asp Ala Asn Lys Ser 
                965                 970                 975     


Glu Ser Glu Pro Asp Phe Phe Ser Pro Ser Leu Asp Gly Asp Gly Asp 
            980                 985                 990         


Arg Lys Lys Cys Leu Ala Leu Val  Ser Leu Gly Glu His  Pro Glu Leu 
        995                 1000                 1005             


Arg Lys  Ser Leu Leu Pro Pro  Leu Ile Ile His Xaa  Ala Ala Xaa 
    1010                 1015                 1020             


Pro Met  Ser Leu Pro Lys Ser  Xaa Ser Xaa Gly Leu  Gly Glu Ala 
    1025                 1030                 1035             


Leu Gly  Pro Ala Ser Arg Arg  Xaa Ser Ser Ser Gly  Ser Ala Glu 
    1040                 1045                 1050             


Pro Gly  Ala Ala His Glu Met  Lys Ser Pro Pro Ser  Ala Arg Ser 
    1055                 1060                 1065             


Ser Pro  His Ser Pro Trp Ser  Ala Ala Ser Ser Trp  Xaa Ser Arg 
    1070                 1075                 1080             


Arg Ser  Ser Arg Asn Ser Leu  Gly Arg Ala Pro Ser  Leu Lys Arg 
    1085                 1090                 1095             


Arg Ser  Pro Ser Gly Glu Arg  Arg Ser Leu Leu Ser  Gly Glu Gly 
    1100                 1105                 1110             


Gln Glu  Ser Gln Asp Glu Glu  Glu Ser Ser Glu Glu  Glu Arg Ala 
    1115                 1120                 1125             


Ser Pro  Ala Gly Ser Asp His  Arg His Arg Gly Ser  Leu Glu Arg 
    1130                 1135                 1140             


Glu Ala  Lys Ser Ser Phe Asp  Leu Pro Asp Xaa Leu  Gln Val Pro 
    1145                 1150                 1155             


Gly Leu  His Arg Xaa Ala Ser  Gly Arg Gly Ser Ala  Ser Glu His 
    1160                 1165                 1170             


Gln Asp  Cys Asn Gly Lys Ser  Ala Ser Gly Arg Leu  Ala Arg Ala 
    1175                 1180                 1185             


Leu Arg  Pro Asp Asp Pro Pro  Leu Asp Gly Asp Asp  Ala Asp Asp 
    1190                 1195                 1200             


Glu Gly  Asn Leu Ser Lys Gly  Glu Arg Val Arg Ala  Trp Ile Arg 
    1205                 1210                 1215             


Ala Arg  Leu Pro Ala Cys Cys  Leu Glu Arg Asp Ser  Trp Ser Ala 
    1220                 1225                 1230             


Tyr Ile  Phe Pro Pro Gln Ser  Arg Phe Arg Leu Leu  Cys His Arg 
    1235                 1240                 1245             


Ile Ile  Xaa His Lys Met Phe  Asp His Val Val Leu  Val Ile Ile 
    1250                 1255                 1260             


Phe Leu  Asn Cys Ile Xaa Ile  Ala Met Glu Arg Pro  Lys Ile Asp 
    1265                 1270                 1275             


Pro His  Ser Ala Glu Arg Ile  Phe Leu Xaa Leu Ser  Asn Tyr Ile 
    1280                 1285                 1290             


Phe Xaa  Ala Val Phe Leu Ala  Glu Met Xaa Val Lys  Val Val Ala 
    1295                 1300                 1305             


Leu Gly  Trp Cys Phe Gly Glu  Gln Ala Tyr Leu Arg  Ser Ser Trp 
    1310                 1315                 1320             


Asn Val  Leu Asp Gly Leu Leu  Val Leu Ile Ser Val  Ile Asp Ile 
    1325                 1330                 1335             


Leu Val  Ser Met Val Ser Asp  Ser Gly Xaa Lys Ile  Leu Gly Met 
    1340                 1345                 1350             


Leu Arg  Val Leu Arg Leu Leu  Arg Xaa Leu Arg Pro  Leu Arg Val 
    1355                 1360                 1365             


Ile Ser  Arg Ala Gln Gly Leu  Lys Leu Val Val Glu  Xaa Leu Met 
    1370                 1375                 1380             


Ser Ser  Leu Lys Pro Ile Gly  Asn Ile Val Val Ile  Cys Cys Ala 
    1385                 1390                 1395             


Phe Phe  Ile Ile Phe Gly Ile  Leu Gly Val Gln Leu  Phe Lys Gly 
    1400                 1405                 1410             


Lys Phe  Phe Val Cys Gln Gly  Glu Asp Xaa Arg Asn  Ile Xaa Asn 
    1415                 1420                 1425             


Lys Ser  Asp Cys Ala Glu Ala  Ser Tyr Arg Trp Val  Arg His Lys 
    1430                 1435                 1440             


Tyr Asn  Phe Asp Asn Leu Gly  Gln Ala Leu Met Ser  Leu Phe Val 
    1445                 1450                 1455             


Leu Ala  Ser Lys Asp Gly Trp  Val Asp Ile Met Tyr  Asp Gly Leu 
    1460                 1465                 1470             


Asp Ala  Val Gly Val Asp Gln  Gln Pro Ile Met Asn  His Asn Pro 
    1475                 1480                 1485             


Trp Met  Leu Leu Tyr Phe Ile  Ser Phe Leu Leu Ile  Val Ala Phe 
    1490                 1495                 1500             


Phe Val  Leu Asn Met Phe Val  Gly Val Val Val Glu  Asn Phe His 
    1505                 1510                 1515             


Lys Cys  Arg Gln His Gln Glu  Glu Glu Glu Ala Arg  Arg Arg Glu 
    1520                 1525                 1530             


Glu Lys  Arg Leu Arg Arg Leu  Glu Lys Lys Arg Arg  Lys Ala Gln 
    1535                 1540                 1545             


Cys Lys  Pro Tyr Tyr Ser Asp  Tyr Ser Arg Phe Arg  Leu Leu Val 
    1550                 1555                 1560             


His His  Leu Cys Xaa Ser His  Tyr Leu Asp Leu Phe  Ile Xaa Gly 
    1565                 1570                 1575             


Val Ile  Gly Leu Asn Val Val  Xaa Met Ala Met Glu  His Tyr Gln 
    1580                 1585                 1590             


Gln Pro  Gln Ile Leu Asp Glu  Ala Leu Lys Ile Cys  Asn Tyr Ile 
    1595                 1600                 1605             


Phe Xaa  Val Ile Phe Val Leu  Glu Ser Val Phe Lys  Leu Val Ala 
    1610                 1615                 1620             


Phe Gly  Phe Arg Arg Phe Phe  Gln Asp Arg Trp Asn  Gln Leu Asp 
    1625                 1630                 1635             


Leu Ala  Ile Val Leu Leu Ser  Ile Met Gly Ile Xaa  Leu Glu Glu 
    1640                 1645                 1650             


Ile Glu  Val Asn Ala Ser Leu  Pro Ile Asn Pro Xaa  Ile Ile Arg 
    1655                 1660                 1665             


Ile Met  Arg Val Leu Arg Ile  Ala Arg Val Leu Lys  Leu Leu Lys 
    1670                 1675                 1680             


Met Ala  Val Gly Met Arg Ala  Leu Leu Asp Xaa Val  Met Gln Ala 
    1685                 1690                 1695             


Leu Pro  Gln Val Gly Asn Leu  Gly Leu Leu Phe Met  Leu Leu Phe 
    1700                 1705                 1710             


Phe Ile  Phe Ala Ala Leu Gly  Val Glu Leu Phe Gly  Asp Leu Glu 
    1715                 1720                 1725             


Cys Asp  Glu Xaa His Pro Cys  Glu Gly Leu Gly Arg  His Ala Xaa 
    1730                 1735                 1740             


Phe Arg  Asn Phe Gly Met Ala  Phe Leu Xaa Leu Phe  Arg Val Ser 
    1745                 1750                 1755             


Xaa Gly  Asp Asn Trp Asn Gly  Ile Met Lys Asp Xaa  Leu Arg Asp 
    1760                 1765                 1770             


Cys Asp  Gln Glu Ser Xaa Cys  Tyr Asn Xaa Val Ile  Ser Pro Ile 
    1775                 1780                 1785             


Tyr Phe  Val Ser Phe Val Leu  Xaa Ala Gln Phe Val  Leu Val Asn 
    1790                 1795                 1800             


Val Val  Ile Ala Val Leu Met  Lys His Leu Glu Glu  Ser Asn Lys 
    1805                 1810                 1815             


Glu Ala  Lys Glu Glu Ala Glu  Leu Glu Ala Glu Leu  Glu Leu Glu 
    1820                 1825                 1830             


Met Lys  Xaa Leu Ser Pro Gln  Pro His Ser Pro Leu  Gly Ser Pro 
    1835                 1840                 1845             


Phe Leu  Trp Pro Gly Val Glu  Gly Pro Asp Ser Pro  Asp Ser Pro 
    1850                 1855                 1860             


Lys Pro  Gly Ala Leu His Pro  Ala Ala His Ala Arg  Ser Ala Ser 
    1865                 1870                 1875             


His Phe  Ser Leu Glu His Pro  Xaa Met Gln Pro His  Pro Xaa Glu 
    1880                 1885                 1890             


Leu Pro  Gly Pro Asp Leu Leu  Xaa Val Arg Lys Ser  Gly Val Ser 
    1895                 1900                 1905             


Arg Xaa  His Ser Leu Pro Asn  Asp Ser Tyr Met Cys  Arg His Gly 
    1910                 1915                 1920             


Ser Xaa  Ala Glu Gly Pro Leu  Gly His Arg Gly Trp  Gly Leu Pro 
    1925                 1930                 1935             


Lys Ala  Gln Ser Gly Ser Val  Leu Ser Val His Ser  Gln Pro Ala 
    1940                 1945                 1950             


Asp Xaa  Ser Tyr Ile Leu Gln  Leu Pro Lys Asp Ala  Pro His Leu 
    1955                 1960                 1965             


Leu Gln  Pro His Ser Ala Pro  Xaa Trp Gly Xaa Ile  Pro Lys Leu 
    1970                 1975                 1980             


Pro Pro  Pro Gly Arg Ser Pro  Leu Ala Gln Arg Pro  Leu Arg Arg 
    1985                 1990                 1995             


Gln Ala  Ala Ile Arg Xaa Asp  Ser Leu Asp Val Gln  Gly Leu Gly 
    2000                 2005                 2010             


Ser Arg  Glu Asp Leu Leu Ala  Glu Val Ser Gly Pro  Ser Pro Pro 
    2015                 2020                 2025             


Leu Ala  Arg Ala Tyr Ser Phe  Trp Gly Gln Ser Ser  Xaa Gln Ala 
    2030                 2035                 2040             


Gln Gln  His Ser Arg Ser His  Ser Lys Ile Ser Lys  His Met Xaa 
    2045                 2050                 2055             


Pro Pro  Ala Pro Cys Pro Gly  Pro Glu Pro Asn Trp  Gly Lys Gly 
    2060                 2065                 2070             


Pro Pro  Glu Xaa Arg Ser Ser  Leu Glu Leu Asp Xaa  Glu Leu Ser 
    2075                 2080                 2085             


Trp Ile  Ser Gly Asp Leu Leu  Pro Pro Gly Gly Gln  Glu Glu Pro 
    2090                 2095                 2100             


Pro Ser  Pro Arg Asp Leu Lys  Lys Cys Tyr Ser Val  Glu Ala Gln 
    2105                 2110                 2115             


Ser Cys  Gln Arg Arg Pro Xaa  Ser Trp Leu Asp Glu  Gln Arg Arg 
    2120                 2125                 2130             


His Ser  Ile Ala Val Ser Cys  Leu Asp Ser Gly Ser  Gln Pro His 
    2135                 2140                 2145             


Leu Gly  Xaa Asp Pro Ser Asn  Leu Gly Gly Gln Pro  Leu Gly Gly 
    2150                 2155                 2160             


Pro Gly  Ser Arg Pro Lys Lys  Lys Leu Ser Pro Pro  Ser Ile Xaa 
    2165                 2170                 2175             


Ile Asp  Pro Pro Glu Ser Gln  Gly Pro Arg Xaa Pro  Pro Ser Pro 
    2180                 2185                 2190             


Gly Ile  Cys Leu Arg Arg Arg  Ala Pro Ser Ser Asp  Ser Lys Asp 
    2195                 2200                 2205             


Pro Leu  Ala Ser Gly Pro Pro  Asp Ser Met Ala Ala  Ser Pro Ser 
    2210                 2215                 2220             


Pro Lys  Lys Asp Val Leu Ser  Leu Ser Gly Leu Ser  Ser Asp Pro 
    2225                 2230                 2235             


Ala Asp  Leu Asp Pro 
    2240             


<210> 4710
<211> 2250
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1575)..(1575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1584)..(1584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1593)..(1593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1617)..(1617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1672)..(1672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1701)..(1701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1739)..(1739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1750)..(1750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1766)..(1766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1777)..(1777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1786)..(1786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1803)..(1803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1843)..(1843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1893)..(1893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1899)..(1899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1908)..(1908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1917)..(1917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1932)..(1932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1962)..(1962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1983)..(1983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1986)..(1986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2011)..(2011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2048)..(2048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2065)..(2065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2084)..(2084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2092)..(2092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2132)..(2132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2158)..(2158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2185)..(2185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2196)..(2196)
<223> Selenocysteine

<400> 4710
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Gly Asp Ala Asn Lys Ser 
                965                 970                 975     


Glu Ser Glu Pro Asp Phe Phe Ser Pro Ser Leu Asp Gly Asp Gly Asp 
            980                 985                 990         


Arg Lys Lys Cys Leu Ala Leu Val  Ser Leu Gly Glu His  Pro Glu Leu 
        995                 1000                 1005             


Arg Lys  Ser Leu Leu Pro Pro  Leu Ile Ile His Xaa  Ala Ala Xaa 
    1010                 1015                 1020             


Pro Met  Ser Leu Pro Lys Ser  Xaa Ser Xaa Gly Leu  Gly Glu Ala 
    1025                 1030                 1035             


Leu Gly  Pro Ala Ser Arg Arg  Xaa Ser Ser Ser Gly  Ser Ala Glu 
    1040                 1045                 1050             


Pro Gly  Ala Ala His Glu Met  Lys Ser Pro Pro Ser  Ala Arg Ser 
    1055                 1060                 1065             


Ser Pro  His Ser Pro Trp Ser  Ala Ala Ser Ser Trp  Xaa Ser Arg 
    1070                 1075                 1080             


Arg Ser  Ser Arg Asn Ser Leu  Gly Arg Ala Pro Ser  Leu Lys Arg 
    1085                 1090                 1095             


Arg Ser  Pro Ser Gly Glu Arg  Arg Ser Leu Leu Ser  Gly Glu Gly 
    1100                 1105                 1110             


Gln Glu  Ser Gln Asp Glu Glu  Glu Ser Ser Glu Glu  Glu Arg Ala 
    1115                 1120                 1125             


Ser Pro  Ala Gly Ser Asp His  Arg His Arg Gly Ser  Leu Glu Arg 
    1130                 1135                 1140             


Glu Ala  Lys Ser Ser Phe Asp  Leu Pro Asp Xaa Leu  Gln Val Pro 
    1145                 1150                 1155             


Gly Leu  His Arg Xaa Ala Ser  Gly Arg Gly Ser Ala  Ser Glu His 
    1160                 1165                 1170             


Gln Asp  Cys Asn Gly Lys Ser  Ala Ser Gly Arg Leu  Ala Arg Ala 
    1175                 1180                 1185             


Leu Arg  Pro Asp Asp Pro Pro  Leu Asp Gly Asp Asp  Ala Asp Asp 
    1190                 1195                 1200             


Glu Gly  Asn Leu Ser Lys Gly  Glu Arg Val Arg Ala  Trp Ile Arg 
    1205                 1210                 1215             


Ala Arg  Leu Pro Ala Cys Cys  Leu Glu Arg Asp Ser  Trp Ser Ala 
    1220                 1225                 1230             


Tyr Ile  Phe Pro Pro Gln Ser  Arg Phe Arg Leu Leu  Cys His Arg 
    1235                 1240                 1245             


Ile Ile  Xaa His Lys Met Phe  Asp His Val Val Leu  Val Ile Ile 
    1250                 1255                 1260             


Phe Leu  Asn Cys Ile Xaa Ile  Ala Met Glu Arg Pro  Lys Ile Asp 
    1265                 1270                 1275             


Pro His  Ser Ala Glu Arg Ile  Phe Leu Xaa Leu Ser  Asn Tyr Ile 
    1280                 1285                 1290             


Phe Xaa  Ala Val Phe Leu Ala  Glu Met Xaa Val Lys  Val Val Ala 
    1295                 1300                 1305             


Leu Gly  Trp Cys Phe Gly Glu  Gln Ala Tyr Leu Arg  Ser Ser Trp 
    1310                 1315                 1320             


Asn Val  Leu Asp Gly Leu Leu  Val Leu Ile Ser Val  Ile Asp Ile 
    1325                 1330                 1335             


Leu Val  Ser Met Val Ser Asp  Ser Gly Xaa Lys Ile  Leu Gly Met 
    1340                 1345                 1350             


Leu Arg  Val Leu Arg Leu Leu  Arg Xaa Leu Arg Pro  Leu Arg Val 
    1355                 1360                 1365             


Ile Ser  Arg Ala Gln Gly Leu  Lys Leu Val Val Glu  Xaa Leu Met 
    1370                 1375                 1380             


Ser Ser  Leu Lys Pro Ile Gly  Asn Ile Val Val Ile  Cys Cys Ala 
    1385                 1390                 1395             


Phe Phe  Ile Ile Phe Gly Ile  Leu Gly Val Gln Leu  Phe Lys Gly 
    1400                 1405                 1410             


Lys Phe  Phe Val Cys Gln Gly  Glu Asp Xaa Arg Asn  Ile Xaa Asn 
    1415                 1420                 1425             


Lys Ser  Asp Cys Ala Glu Ala  Ser Tyr Arg Trp Val  Arg His Lys 
    1430                 1435                 1440             


Tyr Asn  Phe Asp Asn Leu Gly  Gln Ala Leu Met Ser  Leu Phe Val 
    1445                 1450                 1455             


Leu Ala  Ser Lys Asp Gly Trp  Val Asp Ile Met Tyr  Asp Gly Leu 
    1460                 1465                 1470             


Asp Ala  Val Gly Val Asp Gln  Gln Pro Ile Met Asn  His Asn Pro 
    1475                 1480                 1485             


Trp Met  Leu Leu Tyr Phe Ile  Ser Phe Leu Leu Ile  Val Ala Phe 
    1490                 1495                 1500             


Phe Val  Leu Asn Met Phe Val  Gly Val Val Val Glu  Asn Phe His 
    1505                 1510                 1515             


Lys Cys  Arg Gln His Gln Glu  Glu Glu Glu Ala Arg  Arg Arg Glu 
    1520                 1525                 1530             


Glu Lys  Arg Leu Arg Arg Leu  Glu Lys Lys Arg Arg  Ser Lys Glu 
    1535                 1540                 1545             


Lys Gln  Met Ala Glu Ala Gln  Cys Lys Pro Tyr Tyr  Ser Asp Tyr 
    1550                 1555                 1560             


Ser Arg  Phe Arg Leu Leu Val  His His Leu Cys Xaa  Ser His Tyr 
    1565                 1570                 1575             


Leu Asp  Leu Phe Ile Xaa Gly  Val Ile Gly Leu Asn  Val Val Xaa 
    1580                 1585                 1590             


Met Ala  Met Glu His Tyr Gln  Gln Pro Gln Ile Leu  Asp Glu Ala 
    1595                 1600                 1605             


Leu Lys  Ile Cys Asn Tyr Ile  Phe Xaa Val Ile Phe  Val Leu Glu 
    1610                 1615                 1620             


Ser Val  Phe Lys Leu Val Ala  Phe Gly Phe Arg Arg  Phe Phe Gln 
    1625                 1630                 1635             


Asp Arg  Trp Asn Gln Leu Asp  Leu Ala Ile Val Leu  Leu Ser Ile 
    1640                 1645                 1650             


Met Gly  Ile Xaa Leu Glu Glu  Ile Glu Val Asn Ala  Ser Leu Pro 
    1655                 1660                 1665             


Ile Asn  Pro Xaa Ile Ile Arg  Ile Met Arg Val Leu  Arg Ile Ala 
    1670                 1675                 1680             


Arg Val  Leu Lys Leu Leu Lys  Met Ala Val Gly Met  Arg Ala Leu 
    1685                 1690                 1695             


Leu Asp  Xaa Val Met Gln Ala  Leu Pro Gln Val Gly  Asn Leu Gly 
    1700                 1705                 1710             


Leu Leu  Phe Met Leu Leu Phe  Phe Ile Phe Ala Ala  Leu Gly Val 
    1715                 1720                 1725             


Glu Leu  Phe Gly Asp Leu Glu  Cys Asp Glu Xaa His  Pro Cys Glu 
    1730                 1735                 1740             


Gly Leu  Gly Arg His Ala Xaa  Phe Arg Asn Phe Gly  Met Ala Phe 
    1745                 1750                 1755             


Leu Xaa  Leu Phe Arg Val Ser  Xaa Gly Asp Asn Trp  Asn Gly Ile 
    1760                 1765                 1770             


Met Lys  Asp Xaa Leu Arg Asp  Cys Asp Gln Glu Ser  Xaa Cys Tyr 
    1775                 1780                 1785             


Asn Xaa  Val Ile Ser Pro Ile  Tyr Phe Val Ser Phe  Val Leu Xaa 
    1790                 1795                 1800             


Ala Gln  Phe Val Leu Val Asn  Val Val Ile Ala Val  Leu Met Lys 
    1805                 1810                 1815             


His Leu  Glu Glu Ser Asn Lys  Glu Ala Lys Glu Glu  Ala Glu Leu 
    1820                 1825                 1830             


Glu Ala  Glu Leu Glu Leu Glu  Met Lys Xaa Leu Ser  Pro Gln Pro 
    1835                 1840                 1845             


His Ser  Pro Leu Gly Ser Pro  Phe Leu Trp Pro Gly  Val Glu Gly 
    1850                 1855                 1860             


Pro Asp  Ser Pro Asp Ser Pro  Lys Pro Gly Ala Leu  His Pro Ala 
    1865                 1870                 1875             


Ala His  Ala Arg Ser Ala Ser  His Phe Ser Leu Glu  His Pro Xaa 
    1880                 1885                 1890             


Met Gln  Pro His Pro Xaa Glu  Leu Pro Gly Pro Asp  Leu Leu Xaa 
    1895                 1900                 1905             


Val Arg  Lys Ser Gly Val Ser  Arg Xaa His Ser Leu  Pro Asn Asp 
    1910                 1915                 1920             


Ser Tyr  Met Cys Arg His Gly  Ser Xaa Ala Glu Gly  Pro Leu Gly 
    1925                 1930                 1935             


His Arg  Gly Trp Gly Leu Pro  Lys Ala Gln Ser Gly  Ser Val Leu 
    1940                 1945                 1950             


Ser Val  His Ser Gln Pro Ala  Asp Xaa Ser Tyr Ile  Leu Gln Leu 
    1955                 1960                 1965             


Pro Lys  Asp Ala Pro His Leu  Leu Gln Pro His Ser  Ala Pro Xaa 
    1970                 1975                 1980             


Trp Gly  Xaa Ile Pro Lys Leu  Pro Pro Pro Gly Arg  Ser Pro Leu 
    1985                 1990                 1995             


Ala Gln  Arg Pro Leu Arg Arg  Gln Ala Ala Ile Arg  Xaa Asp Ser 
    2000                 2005                 2010             


Leu Asp  Val Gln Gly Leu Gly  Ser Arg Glu Asp Leu  Leu Ala Glu 
    2015                 2020                 2025             


Val Ser  Gly Pro Ser Pro Pro  Leu Ala Arg Ala Tyr  Ser Phe Trp 
    2030                 2035                 2040             


Gly Gln  Ser Ser Xaa Gln Ala  Gln Gln His Ser Arg  Ser His Ser 
    2045                 2050                 2055             


Lys Ile  Ser Lys His Met Xaa  Pro Pro Ala Pro Cys  Pro Gly Pro 
    2060                 2065                 2070             


Glu Pro  Asn Trp Gly Lys Gly  Pro Pro Glu Xaa Arg  Ser Ser Leu 
    2075                 2080                 2085             


Glu Leu  Asp Xaa Glu Leu Ser  Trp Ile Ser Gly Asp  Leu Leu Pro 
    2090                 2095                 2100             


Pro Gly  Gly Gln Glu Glu Pro  Pro Ser Pro Arg Asp  Leu Lys Lys 
    2105                 2110                 2115             


Cys Tyr  Ser Val Glu Ala Gln  Ser Cys Gln Arg Arg  Pro Xaa Ser 
    2120                 2125                 2130             


Trp Leu  Asp Glu Gln Arg Arg  His Ser Ile Ala Val  Ser Cys Leu 
    2135                 2140                 2145             


Asp Ser  Gly Ser Gln Pro His  Leu Gly Xaa Asp Pro  Ser Asn Leu 
    2150                 2155                 2160             


Gly Gly  Gln Pro Leu Gly Gly  Pro Gly Ser Arg Pro  Lys Lys Lys 
    2165                 2170                 2175             


Leu Ser  Pro Pro Ser Ile Xaa  Ile Asp Pro Pro Glu  Ser Gln Gly 
    2180                 2185                 2190             


Pro Arg  Xaa Pro Pro Ser Pro  Gly Ile Cys Leu Arg  Arg Arg Ala 
    2195                 2200                 2205             


Pro Ser  Ser Asp Ser Lys Asp  Pro Leu Ala Ser Gly  Pro Pro Asp 
    2210                 2215                 2220             


Ser Met  Ala Ala Ser Pro Ser  Pro Lys Lys Asp Val  Leu Ser Leu 
    2225                 2230                 2235             


Ser Gly  Leu Ser Ser Asp Pro  Ala Asp Leu Asp Pro  
    2240                 2245                 2250 


<210> 4711
<211> 2250
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1575)..(1575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1584)..(1584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1593)..(1593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1617)..(1617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1672)..(1672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1701)..(1701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1739)..(1739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1750)..(1750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1766)..(1766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1777)..(1777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1786)..(1786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1803)..(1803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1843)..(1843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1893)..(1893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1899)..(1899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1908)..(1908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1917)..(1917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1932)..(1932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1962)..(1962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1983)..(1983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1986)..(1986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2011)..(2011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2048)..(2048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2065)..(2065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2084)..(2084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2092)..(2092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2132)..(2132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2158)..(2158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2185)..(2185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2196)..(2196)
<223> Selenocysteine

<400> 4711
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Asn  Phe His Lys Cys Arg  Gln His Gln Glu Glu  Glu Glu Ala 
    1505                 1510                 1515             


Arg Arg  Arg Glu Glu Lys Arg  Leu Arg Arg Leu Glu  Lys Lys Arg 
    1520                 1525                 1530             


Arg Asn  Leu Met Leu Asp Asp  Val Ile Ala Ser Gly  Ser Ser Ala 
    1535                 1540                 1545             


Ser Ala  Ala Ser Glu Ala Gln  Cys Lys Pro Tyr Tyr  Ser Asp Tyr 
    1550                 1555                 1560             


Ser Arg  Phe Arg Leu Leu Val  His His Leu Cys Xaa  Ser His Tyr 
    1565                 1570                 1575             


Leu Asp  Leu Phe Ile Xaa Gly  Val Ile Gly Leu Asn  Val Val Xaa 
    1580                 1585                 1590             


Met Ala  Met Glu His Tyr Gln  Gln Pro Gln Ile Leu  Asp Glu Ala 
    1595                 1600                 1605             


Leu Lys  Ile Cys Asn Tyr Ile  Phe Xaa Val Ile Phe  Val Leu Glu 
    1610                 1615                 1620             


Ser Val  Phe Lys Leu Val Ala  Phe Gly Phe Arg Arg  Phe Phe Gln 
    1625                 1630                 1635             


Asp Arg  Trp Asn Gln Leu Asp  Leu Ala Ile Val Leu  Leu Ser Ile 
    1640                 1645                 1650             


Met Gly  Ile Xaa Leu Glu Glu  Ile Glu Val Asn Ala  Ser Leu Pro 
    1655                 1660                 1665             


Ile Asn  Pro Xaa Ile Ile Arg  Ile Met Arg Val Leu  Arg Ile Ala 
    1670                 1675                 1680             


Arg Val  Leu Lys Leu Leu Lys  Met Ala Val Gly Met  Arg Ala Leu 
    1685                 1690                 1695             


Leu Asp  Xaa Val Met Gln Ala  Leu Pro Gln Val Gly  Asn Leu Gly 
    1700                 1705                 1710             


Leu Leu  Phe Met Leu Leu Phe  Phe Ile Phe Ala Ala  Leu Gly Val 
    1715                 1720                 1725             


Glu Leu  Phe Gly Asp Leu Glu  Cys Asp Glu Xaa His  Pro Cys Glu 
    1730                 1735                 1740             


Gly Leu  Gly Arg His Ala Xaa  Phe Arg Asn Phe Gly  Met Ala Phe 
    1745                 1750                 1755             


Leu Xaa  Leu Phe Arg Val Ser  Xaa Gly Asp Asn Trp  Asn Gly Ile 
    1760                 1765                 1770             


Met Lys  Asp Xaa Leu Arg Asp  Cys Asp Gln Glu Ser  Xaa Cys Tyr 
    1775                 1780                 1785             


Asn Xaa  Val Ile Ser Pro Ile  Tyr Phe Val Ser Phe  Val Leu Xaa 
    1790                 1795                 1800             


Ala Gln  Phe Val Leu Val Asn  Val Val Ile Ala Val  Leu Met Lys 
    1805                 1810                 1815             


His Leu  Glu Glu Ser Asn Lys  Glu Ala Lys Glu Glu  Ala Glu Leu 
    1820                 1825                 1830             


Glu Ala  Glu Leu Glu Leu Glu  Met Lys Xaa Leu Ser  Pro Gln Pro 
    1835                 1840                 1845             


His Ser  Pro Leu Gly Ser Pro  Phe Leu Trp Pro Gly  Val Glu Gly 
    1850                 1855                 1860             


Pro Asp  Ser Pro Asp Ser Pro  Lys Pro Gly Ala Leu  His Pro Ala 
    1865                 1870                 1875             


Ala His  Ala Arg Ser Ala Ser  His Phe Ser Leu Glu  His Pro Xaa 
    1880                 1885                 1890             


Met Gln  Pro His Pro Xaa Glu  Leu Pro Gly Pro Asp  Leu Leu Xaa 
    1895                 1900                 1905             


Val Arg  Lys Ser Gly Val Ser  Arg Xaa His Ser Leu  Pro Asn Asp 
    1910                 1915                 1920             


Ser Tyr  Met Cys Arg His Gly  Ser Xaa Ala Glu Gly  Pro Leu Gly 
    1925                 1930                 1935             


His Arg  Gly Trp Gly Leu Pro  Lys Ala Gln Ser Gly  Ser Val Leu 
    1940                 1945                 1950             


Ser Val  His Ser Gln Pro Ala  Asp Xaa Ser Tyr Ile  Leu Gln Leu 
    1955                 1960                 1965             


Pro Lys  Asp Ala Pro His Leu  Leu Gln Pro His Ser  Ala Pro Xaa 
    1970                 1975                 1980             


Trp Gly  Xaa Ile Pro Lys Leu  Pro Pro Pro Gly Arg  Ser Pro Leu 
    1985                 1990                 1995             


Ala Gln  Arg Pro Leu Arg Arg  Gln Ala Ala Ile Arg  Xaa Asp Ser 
    2000                 2005                 2010             


Leu Asp  Val Gln Gly Leu Gly  Ser Arg Glu Asp Leu  Leu Ala Glu 
    2015                 2020                 2025             


Val Ser  Gly Pro Ser Pro Pro  Leu Ala Arg Ala Tyr  Ser Phe Trp 
    2030                 2035                 2040             


Gly Gln  Ser Ser Xaa Gln Ala  Gln Gln His Ser Arg  Ser His Ser 
    2045                 2050                 2055             


Lys Ile  Ser Lys His Met Xaa  Pro Pro Ala Pro Cys  Pro Gly Pro 
    2060                 2065                 2070             


Glu Pro  Asn Trp Gly Lys Gly  Pro Pro Glu Xaa Arg  Ser Ser Leu 
    2075                 2080                 2085             


Glu Leu  Asp Xaa Glu Leu Ser  Trp Ile Ser Gly Asp  Leu Leu Pro 
    2090                 2095                 2100             


Pro Gly  Gly Gln Glu Glu Pro  Pro Ser Pro Arg Asp  Leu Lys Lys 
    2105                 2110                 2115             


Cys Tyr  Ser Val Glu Ala Gln  Ser Cys Gln Arg Arg  Pro Xaa Ser 
    2120                 2125                 2130             


Trp Leu  Asp Glu Gln Arg Arg  His Ser Ile Ala Val  Ser Cys Leu 
    2135                 2140                 2145             


Asp Ser  Gly Ser Gln Pro His  Leu Gly Xaa Asp Pro  Ser Asn Leu 
    2150                 2155                 2160             


Gly Gly  Gln Pro Leu Gly Gly  Pro Gly Ser Arg Pro  Lys Lys Lys 
    2165                 2170                 2175             


Leu Ser  Pro Pro Ser Ile Xaa  Ile Asp Pro Pro Glu  Ser Gln Gly 
    2180                 2185                 2190             


Pro Arg  Xaa Pro Pro Ser Pro  Gly Ile Cys Leu Arg  Arg Arg Ala 
    2195                 2200                 2205             


Pro Ser  Ser Asp Ser Lys Asp  Pro Leu Ala Ser Gly  Pro Pro Asp 
    2210                 2215                 2220             


Ser Met  Ala Ala Ser Pro Ser  Pro Lys Lys Asp Val  Leu Ser Leu 
    2225                 2230                 2235             


Ser Gly  Leu Ser Ser Asp Pro  Ala Asp Leu Asp Pro  
    2240                 2245                 2250 


<210> 4712
<211> 2259
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1591)..(1591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1600)..(1600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1673)..(1673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1688)..(1688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1717)..(1717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1748)..(1748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1759)..(1759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1769)..(1769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1775)..(1775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1786)..(1786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1795)..(1795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1799)..(1799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1812)..(1812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1852)..(1852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1902)..(1902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1908)..(1908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1917)..(1917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1926)..(1926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1941)..(1941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1971)..(1971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1992)..(1992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1995)..(1995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2020)..(2020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2057)..(2057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2074)..(2074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2093)..(2093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2101)..(2101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2141)..(2141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2167)..(2167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2194)..(2194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2205)..(2205)
<223> Selenocysteine

<400> 4712
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Pro  Ile Met Asn His Asn  Pro Trp Met Leu Leu  Tyr Phe Ile 
    1505                 1510                 1515             


Ser Phe  Leu Leu Ile Val Ala  Phe Phe Val Leu Asn  Met Phe Val 
    1520                 1525                 1530             


Gly Val  Val Val Glu Asn Phe  His Lys Cys Arg Gln  His Gln Glu 
    1535                 1540                 1545             


Glu Glu  Glu Ala Arg Arg Arg  Glu Glu Lys Arg Leu  Arg Arg Leu 
    1550                 1555                 1560             


Glu Lys  Lys Arg Arg Lys Ala  Gln Cys Lys Pro Tyr  Tyr Ser Asp 
    1565                 1570                 1575             


Tyr Ser  Arg Phe Arg Leu Leu  Val His His Leu Cys  Xaa Ser His 
    1580                 1585                 1590             


Tyr Leu  Asp Leu Phe Ile Xaa  Gly Val Ile Gly Leu  Asn Val Val 
    1595                 1600                 1605             


Xaa Met  Ala Met Glu His Tyr  Gln Gln Pro Gln Ile  Leu Asp Glu 
    1610                 1615                 1620             


Ala Leu  Lys Ile Cys Asn Tyr  Ile Phe Xaa Val Ile  Phe Val Leu 
    1625                 1630                 1635             


Glu Ser  Val Phe Lys Leu Val  Ala Phe Gly Phe Arg  Arg Phe Phe 
    1640                 1645                 1650             


Gln Asp  Arg Trp Asn Gln Leu  Asp Leu Ala Ile Val  Leu Leu Ser 
    1655                 1660                 1665             


Ile Met  Gly Ile Xaa Leu Glu  Glu Ile Glu Val Asn  Ala Ser Leu 
    1670                 1675                 1680             


Pro Ile  Asn Pro Xaa Ile Ile  Arg Ile Met Arg Val  Leu Arg Ile 
    1685                 1690                 1695             


Ala Arg  Val Leu Lys Leu Leu  Lys Met Ala Val Gly  Met Arg Ala 
    1700                 1705                 1710             


Leu Leu  Asp Xaa Val Gly Asn  Leu Gly Leu Leu Phe  Met Leu Leu 
    1715                 1720                 1725             


Phe Phe  Ile Phe Ala Ala Leu  Gly Val Glu Leu Phe  Gly Asp Leu 
    1730                 1735                 1740             


Glu Cys  Asp Glu Xaa His Pro  Cys Glu Gly Leu Gly  Arg His Ala 
    1745                 1750                 1755             


Xaa Phe  Arg Asn Phe Gly Met  Ala Phe Leu Xaa Leu  Phe Arg Val 
    1760                 1765                 1770             


Ser Xaa  Gly Asp Asn Trp Asn  Gly Ile Met Lys Asp  Xaa Leu Arg 
    1775                 1780                 1785             


Asp Cys  Asp Gln Glu Ser Xaa  Cys Tyr Asn Xaa Val  Ile Ser Pro 
    1790                 1795                 1800             


Ile Tyr  Phe Val Ser Phe Val  Leu Xaa Ala Gln Phe  Val Leu Val 
    1805                 1810                 1815             


Asn Val  Val Ile Ala Val Leu  Met Lys His Leu Glu  Glu Ser Asn 
    1820                 1825                 1830             


Lys Glu  Ala Lys Glu Glu Ala  Glu Leu Glu Ala Glu  Leu Glu Leu 
    1835                 1840                 1845             


Glu Met  Lys Xaa Leu Ser Pro  Gln Pro His Ser Pro  Leu Gly Ser 
    1850                 1855                 1860             


Pro Phe  Leu Trp Pro Gly Val  Glu Gly Pro Asp Ser  Pro Asp Ser 
    1865                 1870                 1875             


Pro Lys  Pro Gly Ala Leu His  Pro Ala Ala His Ala  Arg Ser Ala 
    1880                 1885                 1890             


Ser His  Phe Ser Leu Glu His  Pro Xaa Met Gln Pro  His Pro Xaa 
    1895                 1900                 1905             


Glu Leu  Pro Gly Pro Asp Leu  Leu Xaa Val Arg Lys  Ser Gly Val 
    1910                 1915                 1920             


Ser Arg  Xaa His Ser Leu Pro  Asn Asp Ser Tyr Met  Cys Arg His 
    1925                 1930                 1935             


Gly Ser  Xaa Ala Glu Gly Pro  Leu Gly His Arg Gly  Trp Gly Leu 
    1940                 1945                 1950             


Pro Lys  Ala Gln Ser Gly Ser  Val Leu Ser Val His  Ser Gln Pro 
    1955                 1960                 1965             


Ala Asp  Xaa Ser Tyr Ile Leu  Gln Leu Pro Lys Asp  Ala Pro His 
    1970                 1975                 1980             


Leu Leu  Gln Pro His Ser Ala  Pro Xaa Trp Gly Xaa  Ile Pro Lys 
    1985                 1990                 1995             


Leu Pro  Pro Pro Gly Arg Ser  Pro Leu Ala Gln Arg  Pro Leu Arg 
    2000                 2005                 2010             


Arg Gln  Ala Ala Ile Arg Xaa  Asp Ser Leu Asp Val  Gln Gly Leu 
    2015                 2020                 2025             


Gly Ser  Arg Glu Asp Leu Leu  Ala Glu Val Ser Gly  Pro Ser Pro 
    2030                 2035                 2040             


Pro Leu  Ala Arg Ala Tyr Ser  Phe Trp Gly Gln Ser  Ser Xaa Gln 
    2045                 2050                 2055             


Ala Gln  Gln His Ser Arg Ser  His Ser Lys Ile Ser  Lys His Met 
    2060                 2065                 2070             


Xaa Pro  Pro Ala Pro Cys Pro  Gly Pro Glu Pro Asn  Trp Gly Lys 
    2075                 2080                 2085             


Gly Pro  Pro Glu Xaa Arg Ser  Ser Leu Glu Leu Asp  Xaa Glu Leu 
    2090                 2095                 2100             


Ser Trp  Ile Ser Gly Asp Leu  Leu Pro Pro Gly Gly  Gln Glu Glu 
    2105                 2110                 2115             


Pro Pro  Ser Pro Arg Asp Leu  Lys Lys Cys Tyr Ser  Val Glu Ala 
    2120                 2125                 2130             


Gln Ser  Cys Gln Arg Arg Pro  Xaa Ser Trp Leu Asp  Glu Gln Arg 
    2135                 2140                 2145             


Arg His  Ser Ile Ala Val Ser  Cys Leu Asp Ser Gly  Ser Gln Pro 
    2150                 2155                 2160             


His Leu  Gly Xaa Asp Pro Ser  Asn Leu Gly Gly Gln  Pro Leu Gly 
    2165                 2170                 2175             


Gly Pro  Gly Ser Arg Pro Lys  Lys Lys Leu Ser Pro  Pro Ser Ile 
    2180                 2185                 2190             


Xaa Ile  Asp Pro Pro Glu Ser  Gln Gly Pro Arg Xaa  Pro Pro Ser 
    2195                 2200                 2205             


Pro Gly  Ile Cys Leu Arg Arg  Arg Ala Pro Ser Ser  Asp Ser Lys 
    2210                 2215                 2220             


Asp Pro  Leu Ala Ser Gly Pro  Pro Asp Ser Met Ala  Ala Ser Pro 
    2225                 2230                 2235             


Ser Pro  Lys Lys Asp Val Leu  Ser Leu Ser Gly Leu  Ser Ser Asp 
    2240                 2245                 2250             


Pro Ala  Asp Leu Asp Pro 
    2255                 


<210> 4713
<211> 2261
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1595)..(1595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1604)..(1604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1628)..(1628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1668)..(1668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1683)..(1683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1712)..(1712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1750)..(1750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1771)..(1771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1777)..(1777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1788)..(1788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1797)..(1797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1801)..(1801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1814)..(1814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1854)..(1854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1904)..(1904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1910)..(1910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1919)..(1919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1928)..(1928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1943)..(1943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1973)..(1973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1994)..(1994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1997)..(1997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2022)..(2022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2059)..(2059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2076)..(2076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2095)..(2095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2103)..(2103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2143)..(2143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2169)..(2169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2196)..(2196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2207)..(2207)
<223> Selenocysteine

<400> 4713
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Gly Asp Ala Asn Lys Ser 
                965                 970                 975     


Glu Ser Glu Pro Asp Phe Phe Ser Pro Ser Leu Asp Gly Asp Gly Asp 
            980                 985                 990         


Arg Lys Lys Cys Leu Ala Leu Val  Ser Leu Gly Glu His  Pro Glu Leu 
        995                 1000                 1005             


Arg Lys  Ser Leu Leu Pro Pro  Leu Ile Ile His Xaa  Ala Ala Xaa 
    1010                 1015                 1020             


Pro Met  Ser Leu Pro Lys Ser  Xaa Ser Xaa Gly Leu  Gly Glu Ala 
    1025                 1030                 1035             


Leu Gly  Pro Ala Ser Arg Arg  Xaa Ser Ser Ser Gly  Ser Ala Glu 
    1040                 1045                 1050             


Pro Gly  Ala Ala His Glu Met  Lys Ser Pro Pro Ser  Ala Arg Ser 
    1055                 1060                 1065             


Ser Pro  His Ser Pro Trp Ser  Ala Ala Ser Ser Trp  Xaa Ser Arg 
    1070                 1075                 1080             


Arg Ser  Ser Arg Asn Ser Leu  Gly Arg Ala Pro Ser  Leu Lys Arg 
    1085                 1090                 1095             


Arg Ser  Pro Ser Gly Glu Arg  Arg Ser Leu Leu Ser  Gly Glu Gly 
    1100                 1105                 1110             


Gln Glu  Ser Gln Asp Glu Glu  Glu Ser Ser Glu Glu  Glu Arg Ala 
    1115                 1120                 1125             


Ser Pro  Ala Gly Ser Asp His  Arg His Arg Gly Ser  Leu Glu Arg 
    1130                 1135                 1140             


Glu Ala  Lys Ser Ser Phe Asp  Leu Pro Asp Xaa Leu  Gln Val Pro 
    1145                 1150                 1155             


Gly Leu  His Arg Xaa Ala Ser  Gly Arg Gly Ser Ala  Ser Glu His 
    1160                 1165                 1170             


Gln Asp  Cys Asn Gly Lys Ser  Ala Ser Gly Arg Leu  Ala Arg Ala 
    1175                 1180                 1185             


Leu Arg  Pro Asp Asp Pro Pro  Leu Asp Gly Asp Asp  Ala Asp Asp 
    1190                 1195                 1200             


Glu Gly  Asn Leu Ser Lys Gly  Glu Arg Val Arg Ala  Trp Ile Arg 
    1205                 1210                 1215             


Ala Arg  Leu Pro Ala Cys Cys  Leu Glu Arg Asp Ser  Trp Ser Ala 
    1220                 1225                 1230             


Tyr Ile  Phe Pro Pro Gln Ser  Arg Phe Arg Leu Leu  Cys His Arg 
    1235                 1240                 1245             


Ile Ile  Xaa His Lys Met Phe  Asp His Val Val Leu  Val Ile Ile 
    1250                 1255                 1260             


Phe Leu  Asn Cys Ile Xaa Ile  Ala Met Glu Arg Pro  Lys Ile Asp 
    1265                 1270                 1275             


Pro His  Ser Ala Glu Arg Ile  Phe Leu Xaa Leu Ser  Asn Tyr Ile 
    1280                 1285                 1290             


Phe Xaa  Ala Val Phe Leu Ala  Glu Met Xaa Val Lys  Val Val Ala 
    1295                 1300                 1305             


Leu Gly  Trp Cys Phe Gly Glu  Gln Ala Tyr Leu Arg  Ser Ser Trp 
    1310                 1315                 1320             


Asn Val  Leu Asp Gly Leu Leu  Val Leu Ile Ser Val  Ile Asp Ile 
    1325                 1330                 1335             


Leu Val  Ser Met Val Ser Asp  Ser Gly Xaa Lys Ile  Leu Gly Met 
    1340                 1345                 1350             


Leu Arg  Val Leu Arg Leu Leu  Arg Xaa Leu Arg Pro  Leu Arg Val 
    1355                 1360                 1365             


Ile Ser  Arg Ala Gln Gly Leu  Lys Leu Val Val Glu  Xaa Leu Met 
    1370                 1375                 1380             


Ser Ser  Leu Lys Pro Ile Gly  Asn Ile Val Val Ile  Cys Cys Ala 
    1385                 1390                 1395             


Phe Phe  Ile Ile Phe Gly Ile  Leu Gly Val Gln Leu  Phe Lys Gly 
    1400                 1405                 1410             


Lys Phe  Phe Val Cys Gln Gly  Glu Asp Xaa Arg Asn  Ile Xaa Asn 
    1415                 1420                 1425             


Lys Ser  Asp Cys Ala Glu Ala  Ser Tyr Arg Trp Val  Arg His Lys 
    1430                 1435                 1440             


Tyr Asn  Phe Asp Asn Leu Gly  Gln Ala Leu Met Ser  Leu Phe Val 
    1445                 1450                 1455             


Leu Ala  Ser Lys Asp Gly Trp  Val Asp Ile Met Tyr  Asp Gly Leu 
    1460                 1465                 1470             


Asp Ala  Val Gly Val Asp Gln  Gln Pro Ile Met Asn  His Asn Pro 
    1475                 1480                 1485             


Trp Met  Leu Leu Tyr Phe Ile  Ser Phe Leu Leu Ile  Val Ala Phe 
    1490                 1495                 1500             


Phe Val  Leu Asn Met Phe Val  Gly Val Val Val Glu  Asn Phe His 
    1505                 1510                 1515             


Lys Cys  Arg Gln His Gln Glu  Glu Glu Glu Ala Arg  Arg Arg Glu 
    1520                 1525                 1530             


Glu Lys  Arg Leu Arg Arg Leu  Glu Lys Lys Arg Arg  Asn Leu Met 
    1535                 1540                 1545             


Leu Asp  Asp Val Ile Ala Ser  Gly Ser Ser Ala Ser  Ala Ala Ser 
    1550                 1555                 1560             


Glu Ala  Gln Cys Lys Pro Tyr  Tyr Ser Asp Tyr Ser  Arg Phe Arg 
    1565                 1570                 1575             


Leu Leu  Val His His Leu Cys  Xaa Ser His Tyr Leu  Asp Leu Phe 
    1580                 1585                 1590             


Ile Xaa  Gly Val Ile Gly Leu  Asn Val Val Xaa Met  Ala Met Glu 
    1595                 1600                 1605             


His Tyr  Gln Gln Pro Gln Ile  Leu Asp Glu Ala Leu  Lys Ile Cys 
    1610                 1615                 1620             


Asn Tyr  Ile Phe Xaa Val Ile  Phe Val Leu Glu Ser  Val Phe Lys 
    1625                 1630                 1635             


Leu Val  Ala Phe Gly Phe Arg  Arg Phe Phe Gln Asp  Arg Trp Asn 
    1640                 1645                 1650             


Gln Leu  Asp Leu Ala Ile Val  Leu Leu Ser Ile Met  Gly Ile Xaa 
    1655                 1660                 1665             


Leu Glu  Glu Ile Glu Val Asn  Ala Ser Leu Pro Ile  Asn Pro Xaa 
    1670                 1675                 1680             


Ile Ile  Arg Ile Met Arg Val  Leu Arg Ile Ala Arg  Val Leu Lys 
    1685                 1690                 1695             


Leu Leu  Lys Met Ala Val Gly  Met Arg Ala Leu Leu  Asp Xaa Val 
    1700                 1705                 1710             


Met Gln  Ala Leu Pro Gln Val  Gly Asn Leu Gly Leu  Leu Phe Met 
    1715                 1720                 1725             


Leu Leu  Phe Phe Ile Phe Ala  Ala Leu Gly Val Glu  Leu Phe Gly 
    1730                 1735                 1740             


Asp Leu  Glu Cys Asp Glu Xaa  His Pro Cys Glu Gly  Leu Gly Arg 
    1745                 1750                 1755             


His Ala  Xaa Phe Arg Asn Phe  Gly Met Ala Phe Leu  Xaa Leu Phe 
    1760                 1765                 1770             


Arg Val  Ser Xaa Gly Asp Asn  Trp Asn Gly Ile Met  Lys Asp Xaa 
    1775                 1780                 1785             


Leu Arg  Asp Cys Asp Gln Glu  Ser Xaa Cys Tyr Asn  Xaa Val Ile 
    1790                 1795                 1800             


Ser Pro  Ile Tyr Phe Val Ser  Phe Val Leu Xaa Ala  Gln Phe Val 
    1805                 1810                 1815             


Leu Val  Asn Val Val Ile Ala  Val Leu Met Lys His  Leu Glu Glu 
    1820                 1825                 1830             


Ser Asn  Lys Glu Ala Lys Glu  Glu Ala Glu Leu Glu  Ala Glu Leu 
    1835                 1840                 1845             


Glu Leu  Glu Met Lys Xaa Leu  Ser Pro Gln Pro His  Ser Pro Leu 
    1850                 1855                 1860             


Gly Ser  Pro Phe Leu Trp Pro  Gly Val Glu Gly Pro  Asp Ser Pro 
    1865                 1870                 1875             


Asp Ser  Pro Lys Pro Gly Ala  Leu His Pro Ala Ala  His Ala Arg 
    1880                 1885                 1890             


Ser Ala  Ser His Phe Ser Leu  Glu His Pro Xaa Met  Gln Pro His 
    1895                 1900                 1905             


Pro Xaa  Glu Leu Pro Gly Pro  Asp Leu Leu Xaa Val  Arg Lys Ser 
    1910                 1915                 1920             


Gly Val  Ser Arg Xaa His Ser  Leu Pro Asn Asp Ser  Tyr Met Cys 
    1925                 1930                 1935             


Arg His  Gly Ser Xaa Ala Glu  Gly Pro Leu Gly His  Arg Gly Trp 
    1940                 1945                 1950             


Gly Leu  Pro Lys Ala Gln Ser  Gly Ser Val Leu Ser  Val His Ser 
    1955                 1960                 1965             


Gln Pro  Ala Asp Xaa Ser Tyr  Ile Leu Gln Leu Pro  Lys Asp Ala 
    1970                 1975                 1980             


Pro His  Leu Leu Gln Pro His  Ser Ala Pro Xaa Trp  Gly Xaa Ile 
    1985                 1990                 1995             


Pro Lys  Leu Pro Pro Pro Gly  Arg Ser Pro Leu Ala  Gln Arg Pro 
    2000                 2005                 2010             


Leu Arg  Arg Gln Ala Ala Ile  Arg Xaa Asp Ser Leu  Asp Val Gln 
    2015                 2020                 2025             


Gly Leu  Gly Ser Arg Glu Asp  Leu Leu Ala Glu Val  Ser Gly Pro 
    2030                 2035                 2040             


Ser Pro  Pro Leu Ala Arg Ala  Tyr Ser Phe Trp Gly  Gln Ser Ser 
    2045                 2050                 2055             


Xaa Gln  Ala Gln Gln His Ser  Arg Ser His Ser Lys  Ile Ser Lys 
    2060                 2065                 2070             


His Met  Xaa Pro Pro Ala Pro  Cys Pro Gly Pro Glu  Pro Asn Trp 
    2075                 2080                 2085             


Gly Lys  Gly Pro Pro Glu Xaa  Arg Ser Ser Leu Glu  Leu Asp Xaa 
    2090                 2095                 2100             


Glu Leu  Ser Trp Ile Ser Gly  Asp Leu Leu Pro Pro  Gly Gly Gln 
    2105                 2110                 2115             


Glu Glu  Pro Pro Ser Pro Arg  Asp Leu Lys Lys Cys  Tyr Ser Val 
    2120                 2125                 2130             


Glu Ala  Gln Ser Cys Gln Arg  Arg Pro Xaa Ser Trp  Leu Asp Glu 
    2135                 2140                 2145             


Gln Arg  Arg His Ser Ile Ala  Val Ser Cys Leu Asp  Ser Gly Ser 
    2150                 2155                 2160             


Gln Pro  His Leu Gly Xaa Asp  Pro Ser Asn Leu Gly  Gly Gln Pro 
    2165                 2170                 2175             


Leu Gly  Gly Pro Gly Ser Arg  Pro Lys Lys Lys Leu  Ser Pro Pro 
    2180                 2185                 2190             


Ser Ile  Xaa Ile Asp Pro Pro  Glu Ser Gln Gly Pro  Arg Xaa Pro 
    2195                 2200                 2205             


Pro Ser  Pro Gly Ile Cys Leu  Arg Arg Arg Ala Pro  Ser Ser Asp 
    2210                 2215                 2220             


Ser Lys  Asp Pro Leu Ala Ser  Gly Pro Pro Asp Ser  Met Ala Ala 
    2225                 2230                 2235             


Ser Pro  Ser Pro Lys Lys Asp  Val Leu Ser Leu Ser  Gly Leu Ser 
    2240                 2245                 2250             


Ser Asp  Pro Ala Asp Leu Asp  Pro 
    2255                 2260     


<210> 4714
<211> 2266
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1591)..(1591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1600)..(1600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1673)..(1673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1688)..(1688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1717)..(1717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1755)..(1755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1766)..(1766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1776)..(1776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1782)..(1782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1793)..(1793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1802)..(1802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1806)..(1806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1819)..(1819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1859)..(1859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1909)..(1909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1915)..(1915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1924)..(1924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1933)..(1933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1948)..(1948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1978)..(1978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1999)..(1999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2002)..(2002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2027)..(2027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2064)..(2064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2081)..(2081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2100)..(2100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2108)..(2108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2148)..(2148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2174)..(2174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2201)..(2201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2212)..(2212)
<223> Selenocysteine

<400> 4714
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Pro  Ile Met Asn His Asn  Pro Trp Met Leu Leu  Tyr Phe Ile 
    1505                 1510                 1515             


Ser Phe  Leu Leu Ile Val Ala  Phe Phe Val Leu Asn  Met Phe Val 
    1520                 1525                 1530             


Gly Val  Val Val Glu Asn Phe  His Lys Cys Arg Gln  His Gln Glu 
    1535                 1540                 1545             


Glu Glu  Glu Ala Arg Arg Arg  Glu Glu Lys Arg Leu  Arg Arg Leu 
    1550                 1555                 1560             


Glu Lys  Lys Arg Arg Lys Ala  Gln Cys Lys Pro Tyr  Tyr Ser Asp 
    1565                 1570                 1575             


Tyr Ser  Arg Phe Arg Leu Leu  Val His His Leu Cys  Xaa Ser His 
    1580                 1585                 1590             


Tyr Leu  Asp Leu Phe Ile Xaa  Gly Val Ile Gly Leu  Asn Val Val 
    1595                 1600                 1605             


Xaa Met  Ala Met Glu His Tyr  Gln Gln Pro Gln Ile  Leu Asp Glu 
    1610                 1615                 1620             


Ala Leu  Lys Ile Cys Asn Tyr  Ile Phe Xaa Val Ile  Phe Val Leu 
    1625                 1630                 1635             


Glu Ser  Val Phe Lys Leu Val  Ala Phe Gly Phe Arg  Arg Phe Phe 
    1640                 1645                 1650             


Gln Asp  Arg Trp Asn Gln Leu  Asp Leu Ala Ile Val  Leu Leu Ser 
    1655                 1660                 1665             


Ile Met  Gly Ile Xaa Leu Glu  Glu Ile Glu Val Asn  Ala Ser Leu 
    1670                 1675                 1680             


Pro Ile  Asn Pro Xaa Ile Ile  Arg Ile Met Arg Val  Leu Arg Ile 
    1685                 1690                 1695             


Ala Arg  Val Leu Lys Leu Leu  Lys Met Ala Val Gly  Met Arg Ala 
    1700                 1705                 1710             


Leu Leu  Asp Xaa Val Met Gln  Ala Leu Pro Gln Val  Gly Asn Leu 
    1715                 1720                 1725             


Gly Leu  Leu Phe Met Leu Leu  Phe Phe Ile Phe Ala  Ala Leu Gly 
    1730                 1735                 1740             


Val Glu  Leu Phe Gly Asp Leu  Glu Cys Asp Glu Xaa  His Pro Cys 
    1745                 1750                 1755             


Glu Gly  Leu Gly Arg His Ala  Xaa Phe Arg Asn Phe  Gly Met Ala 
    1760                 1765                 1770             


Phe Leu  Xaa Leu Phe Arg Val  Ser Xaa Gly Asp Asn  Trp Asn Gly 
    1775                 1780                 1785             


Ile Met  Lys Asp Xaa Leu Arg  Asp Cys Asp Gln Glu  Ser Xaa Cys 
    1790                 1795                 1800             


Tyr Asn  Xaa Val Ile Ser Pro  Ile Tyr Phe Val Ser  Phe Val Leu 
    1805                 1810                 1815             


Xaa Ala  Gln Phe Val Leu Val  Asn Val Val Ile Ala  Val Leu Met 
    1820                 1825                 1830             


Lys His  Leu Glu Glu Ser Asn  Lys Glu Ala Lys Glu  Glu Ala Glu 
    1835                 1840                 1845             


Leu Glu  Ala Glu Leu Glu Leu  Glu Met Lys Xaa Leu  Ser Pro Gln 
    1850                 1855                 1860             


Pro His  Ser Pro Leu Gly Ser  Pro Phe Leu Trp Pro  Gly Val Glu 
    1865                 1870                 1875             


Gly Pro  Asp Ser Pro Asp Ser  Pro Lys Pro Gly Ala  Leu His Pro 
    1880                 1885                 1890             


Ala Ala  His Ala Arg Ser Ala  Ser His Phe Ser Leu  Glu His Pro 
    1895                 1900                 1905             


Xaa Met  Gln Pro His Pro Xaa  Glu Leu Pro Gly Pro  Asp Leu Leu 
    1910                 1915                 1920             


Xaa Val  Arg Lys Ser Gly Val  Ser Arg Xaa His Ser  Leu Pro Asn 
    1925                 1930                 1935             


Asp Ser  Tyr Met Cys Arg His  Gly Ser Xaa Ala Glu  Gly Pro Leu 
    1940                 1945                 1950             


Gly His  Arg Gly Trp Gly Leu  Pro Lys Ala Gln Ser  Gly Ser Val 
    1955                 1960                 1965             


Leu Ser  Val His Ser Gln Pro  Ala Asp Xaa Ser Tyr  Ile Leu Gln 
    1970                 1975                 1980             


Leu Pro  Lys Asp Ala Pro His  Leu Leu Gln Pro His  Ser Ala Pro 
    1985                 1990                 1995             


Xaa Trp  Gly Xaa Ile Pro Lys  Leu Pro Pro Pro Gly  Arg Ser Pro 
    2000                 2005                 2010             


Leu Ala  Gln Arg Pro Leu Arg  Arg Gln Ala Ala Ile  Arg Xaa Asp 
    2015                 2020                 2025             


Ser Leu  Asp Val Gln Gly Leu  Gly Ser Arg Glu Asp  Leu Leu Ala 
    2030                 2035                 2040             


Glu Val  Ser Gly Pro Ser Pro  Pro Leu Ala Arg Ala  Tyr Ser Phe 
    2045                 2050                 2055             


Trp Gly  Gln Ser Ser Xaa Gln  Ala Gln Gln His Ser  Arg Ser His 
    2060                 2065                 2070             


Ser Lys  Ile Ser Lys His Met  Xaa Pro Pro Ala Pro  Cys Pro Gly 
    2075                 2080                 2085             


Pro Glu  Pro Asn Trp Gly Lys  Gly Pro Pro Glu Xaa  Arg Ser Ser 
    2090                 2095                 2100             


Leu Glu  Leu Asp Xaa Glu Leu  Ser Trp Ile Ser Gly  Asp Leu Leu 
    2105                 2110                 2115             


Pro Pro  Gly Gly Gln Glu Glu  Pro Pro Ser Pro Arg  Asp Leu Lys 
    2120                 2125                 2130             


Lys Cys  Tyr Ser Val Glu Ala  Gln Ser Cys Gln Arg  Arg Pro Xaa 
    2135                 2140                 2145             


Ser Trp  Leu Asp Glu Gln Arg  Arg His Ser Ile Ala  Val Ser Cys 
    2150                 2155                 2160             


Leu Asp  Ser Gly Ser Gln Pro  His Leu Gly Xaa Asp  Pro Ser Asn 
    2165                 2170                 2175             


Leu Gly  Gly Gln Pro Leu Gly  Gly Pro Gly Ser Arg  Pro Lys Lys 
    2180                 2185                 2190             


Lys Leu  Ser Pro Pro Ser Ile  Xaa Ile Asp Pro Pro  Glu Ser Gln 
    2195                 2200                 2205             


Gly Pro  Arg Xaa Pro Pro Ser  Pro Gly Ile Cys Leu  Arg Arg Arg 
    2210                 2215                 2220             


Ala Pro  Ser Ser Asp Ser Lys  Asp Pro Leu Ala Ser  Gly Pro Pro 
    2225                 2230                 2235             


Asp Ser  Met Ala Ala Ser Pro  Ser Pro Lys Lys Asp  Val Leu Ser 
    2240                 2245                 2250             


Leu Ser  Gly Leu Ser Ser Asp  Pro Ala Asp Leu Asp  Pro 
    2255                 2260                 2265     


<210> 4715
<211> 2273
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1598)..(1598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1616)..(1616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1680)..(1680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1695)..(1695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1724)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1762)..(1762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1783)..(1783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1789)..(1789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1800)..(1800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1809)..(1809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1813)..(1813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1826)..(1826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1866)..(1866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1916)..(1916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1922)..(1922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1931)..(1931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1940)..(1940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1955)..(1955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1985)..(1985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2006)..(2006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2009)..(2009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2034)..(2034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2071)..(2071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2088)..(2088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2107)..(2107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2115)..(2115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2155)..(2155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2181)..(2181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2208)..(2208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2219)..(2219)
<223> Selenocysteine

<400> 4715
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Pro  Ile Met Asn His Asn  Pro Trp Met Leu Leu  Tyr Phe Ile 
    1505                 1510                 1515             


Ser Phe  Leu Leu Ile Val Ala  Phe Phe Val Leu Asn  Met Phe Val 
    1520                 1525                 1530             


Gly Val  Val Val Glu Asn Phe  His Lys Cys Arg Gln  His Gln Glu 
    1535                 1540                 1545             


Glu Glu  Glu Ala Arg Arg Arg  Glu Glu Lys Arg Leu  Arg Arg Leu 
    1550                 1555                 1560             


Glu Lys  Lys Arg Arg Ser Lys  Glu Lys Gln Met Ala  Glu Ala Gln 
    1565                 1570                 1575             


Cys Lys  Pro Tyr Tyr Ser Asp  Tyr Ser Arg Phe Arg  Leu Leu Val 
    1580                 1585                 1590             


His His  Leu Cys Xaa Ser His  Tyr Leu Asp Leu Phe  Ile Xaa Gly 
    1595                 1600                 1605             


Val Ile  Gly Leu Asn Val Val  Xaa Met Ala Met Glu  His Tyr Gln 
    1610                 1615                 1620             


Gln Pro  Gln Ile Leu Asp Glu  Ala Leu Lys Ile Cys  Asn Tyr Ile 
    1625                 1630                 1635             


Phe Xaa  Val Ile Phe Val Leu  Glu Ser Val Phe Lys  Leu Val Ala 
    1640                 1645                 1650             


Phe Gly  Phe Arg Arg Phe Phe  Gln Asp Arg Trp Asn  Gln Leu Asp 
    1655                 1660                 1665             


Leu Ala  Ile Val Leu Leu Ser  Ile Met Gly Ile Xaa  Leu Glu Glu 
    1670                 1675                 1680             


Ile Glu  Val Asn Ala Ser Leu  Pro Ile Asn Pro Xaa  Ile Ile Arg 
    1685                 1690                 1695             


Ile Met  Arg Val Leu Arg Ile  Ala Arg Val Leu Lys  Leu Leu Lys 
    1700                 1705                 1710             


Met Ala  Val Gly Met Arg Ala  Leu Leu Asp Xaa Val  Met Gln Ala 
    1715                 1720                 1725             


Leu Pro  Gln Val Gly Asn Leu  Gly Leu Leu Phe Met  Leu Leu Phe 
    1730                 1735                 1740             


Phe Ile  Phe Ala Ala Leu Gly  Val Glu Leu Phe Gly  Asp Leu Glu 
    1745                 1750                 1755             


Cys Asp  Glu Xaa His Pro Cys  Glu Gly Leu Gly Arg  His Ala Xaa 
    1760                 1765                 1770             


Phe Arg  Asn Phe Gly Met Ala  Phe Leu Xaa Leu Phe  Arg Val Ser 
    1775                 1780                 1785             


Xaa Gly  Asp Asn Trp Asn Gly  Ile Met Lys Asp Xaa  Leu Arg Asp 
    1790                 1795                 1800             


Cys Asp  Gln Glu Ser Xaa Cys  Tyr Asn Xaa Val Ile  Ser Pro Ile 
    1805                 1810                 1815             


Tyr Phe  Val Ser Phe Val Leu  Xaa Ala Gln Phe Val  Leu Val Asn 
    1820                 1825                 1830             


Val Val  Ile Ala Val Leu Met  Lys His Leu Glu Glu  Ser Asn Lys 
    1835                 1840                 1845             


Glu Ala  Lys Glu Glu Ala Glu  Leu Glu Ala Glu Leu  Glu Leu Glu 
    1850                 1855                 1860             


Met Lys  Xaa Leu Ser Pro Gln  Pro His Ser Pro Leu  Gly Ser Pro 
    1865                 1870                 1875             


Phe Leu  Trp Pro Gly Val Glu  Gly Pro Asp Ser Pro  Asp Ser Pro 
    1880                 1885                 1890             


Lys Pro  Gly Ala Leu His Pro  Ala Ala His Ala Arg  Ser Ala Ser 
    1895                 1900                 1905             


His Phe  Ser Leu Glu His Pro  Xaa Met Gln Pro His  Pro Xaa Glu 
    1910                 1915                 1920             


Leu Pro  Gly Pro Asp Leu Leu  Xaa Val Arg Lys Ser  Gly Val Ser 
    1925                 1930                 1935             


Arg Xaa  His Ser Leu Pro Asn  Asp Ser Tyr Met Cys  Arg His Gly 
    1940                 1945                 1950             


Ser Xaa  Ala Glu Gly Pro Leu  Gly His Arg Gly Trp  Gly Leu Pro 
    1955                 1960                 1965             


Lys Ala  Gln Ser Gly Ser Val  Leu Ser Val His Ser  Gln Pro Ala 
    1970                 1975                 1980             


Asp Xaa  Ser Tyr Ile Leu Gln  Leu Pro Lys Asp Ala  Pro His Leu 
    1985                 1990                 1995             


Leu Gln  Pro His Ser Ala Pro  Xaa Trp Gly Xaa Ile  Pro Lys Leu 
    2000                 2005                 2010             


Pro Pro  Pro Gly Arg Ser Pro  Leu Ala Gln Arg Pro  Leu Arg Arg 
    2015                 2020                 2025             


Gln Ala  Ala Ile Arg Xaa Asp  Ser Leu Asp Val Gln  Gly Leu Gly 
    2030                 2035                 2040             


Ser Arg  Glu Asp Leu Leu Ala  Glu Val Ser Gly Pro  Ser Pro Pro 
    2045                 2050                 2055             


Leu Ala  Arg Ala Tyr Ser Phe  Trp Gly Gln Ser Ser  Xaa Gln Ala 
    2060                 2065                 2070             


Gln Gln  His Ser Arg Ser His  Ser Lys Ile Ser Lys  His Met Xaa 
    2075                 2080                 2085             


Pro Pro  Ala Pro Cys Pro Gly  Pro Glu Pro Asn Trp  Gly Lys Gly 
    2090                 2095                 2100             


Pro Pro  Glu Xaa Arg Ser Ser  Leu Glu Leu Asp Xaa  Glu Leu Ser 
    2105                 2110                 2115             


Trp Ile  Ser Gly Asp Leu Leu  Pro Pro Gly Gly Gln  Glu Glu Pro 
    2120                 2125                 2130             


Pro Ser  Pro Arg Asp Leu Lys  Lys Cys Tyr Ser Val  Glu Ala Gln 
    2135                 2140                 2145             


Ser Cys  Gln Arg Arg Pro Xaa  Ser Trp Leu Asp Glu  Gln Arg Arg 
    2150                 2155                 2160             


His Ser  Ile Ala Val Ser Cys  Leu Asp Ser Gly Ser  Gln Pro His 
    2165                 2170                 2175             


Leu Gly  Xaa Asp Pro Ser Asn  Leu Gly Gly Gln Pro  Leu Gly Gly 
    2180                 2185                 2190             


Pro Gly  Ser Arg Pro Lys Lys  Lys Leu Ser Pro Pro  Ser Ile Xaa 
    2195                 2200                 2205             


Ile Asp  Pro Pro Glu Ser Gln  Gly Pro Arg Xaa Pro  Pro Ser Pro 
    2210                 2215                 2220             


Gly Ile  Cys Leu Arg Arg Arg  Ala Pro Ser Ser Asp  Ser Lys Asp 
    2225                 2230                 2235             


Pro Leu  Ala Ser Gly Pro Pro  Asp Ser Met Ala Ala  Ser Pro Ser 
    2240                 2245                 2250             


Pro Lys  Lys Asp Val Leu Ser  Leu Ser Gly Leu Ser  Ser Asp Pro 
    2255                 2260                 2265             


Ala Asp  Leu Asp Pro 
    2270             


<210> 4716
<211> 2277
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1618)..(1618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1627)..(1627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1651)..(1651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1691)..(1691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1706)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1735)..(1735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1766)..(1766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1777)..(1777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1793)..(1793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1804)..(1804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1813)..(1813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1817)..(1817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1830)..(1830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1870)..(1870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1920)..(1920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1926)..(1926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1935)..(1935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1944)..(1944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1959)..(1959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1989)..(1989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2010)..(2010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2013)..(2013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2038)..(2038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2075)..(2075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2092)..(2092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2111)..(2111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2119)..(2119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2159)..(2159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2185)..(2185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2212)..(2212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2223)..(2223)
<223> Selenocysteine

<400> 4716
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Pro  Ile Met Asn His Asn  Pro Trp Met Leu Leu  Tyr Phe Ile 
    1505                 1510                 1515             


Ser Phe  Leu Leu Ile Val Ala  Phe Phe Val Leu Asn  Met Phe Val 
    1520                 1525                 1530             


Gly Val  Val Val Glu Asn Phe  His Lys Cys Arg Gln  His Gln Glu 
    1535                 1540                 1545             


Glu Glu  Glu Ala Arg Arg Arg  Glu Glu Lys Arg Leu  Arg Arg Leu 
    1550                 1555                 1560             


Glu Lys  Lys Arg Arg Asn Leu  Met Leu Asp Asp Val  Ile Ala Ser 
    1565                 1570                 1575             


Gly Ser  Ser Ala Ser Ala Ala  Ser Glu Ala Gln Cys  Lys Pro Tyr 
    1580                 1585                 1590             


Tyr Ser  Asp Tyr Ser Arg Phe  Arg Leu Leu Val His  His Leu Cys 
    1595                 1600                 1605             


Xaa Ser  His Tyr Leu Asp Leu  Phe Ile Xaa Gly Val  Ile Gly Leu 
    1610                 1615                 1620             


Asn Val  Val Xaa Met Ala Met  Glu His Tyr Gln Gln  Pro Gln Ile 
    1625                 1630                 1635             


Leu Asp  Glu Ala Leu Lys Ile  Cys Asn Tyr Ile Phe  Xaa Val Ile 
    1640                 1645                 1650             


Phe Val  Leu Glu Ser Val Phe  Lys Leu Val Ala Phe  Gly Phe Arg 
    1655                 1660                 1665             


Arg Phe  Phe Gln Asp Arg Trp  Asn Gln Leu Asp Leu  Ala Ile Val 
    1670                 1675                 1680             


Leu Leu  Ser Ile Met Gly Ile  Xaa Leu Glu Glu Ile  Glu Val Asn 
    1685                 1690                 1695             


Ala Ser  Leu Pro Ile Asn Pro  Xaa Ile Ile Arg Ile  Met Arg Val 
    1700                 1705                 1710             


Leu Arg  Ile Ala Arg Val Leu  Lys Leu Leu Lys Met  Ala Val Gly 
    1715                 1720                 1725             


Met Arg  Ala Leu Leu Asp Xaa  Val Gly Asn Leu Gly  Leu Leu Phe 
    1730                 1735                 1740             


Met Leu  Leu Phe Phe Ile Phe  Ala Ala Leu Gly Val  Glu Leu Phe 
    1745                 1750                 1755             


Gly Asp  Leu Glu Cys Asp Glu  Xaa His Pro Cys Glu  Gly Leu Gly 
    1760                 1765                 1770             


Arg His  Ala Xaa Phe Arg Asn  Phe Gly Met Ala Phe  Leu Xaa Leu 
    1775                 1780                 1785             


Phe Arg  Val Ser Xaa Gly Asp  Asn Trp Asn Gly Ile  Met Lys Asp 
    1790                 1795                 1800             


Xaa Leu  Arg Asp Cys Asp Gln  Glu Ser Xaa Cys Tyr  Asn Xaa Val 
    1805                 1810                 1815             


Ile Ser  Pro Ile Tyr Phe Val  Ser Phe Val Leu Xaa  Ala Gln Phe 
    1820                 1825                 1830             


Val Leu  Val Asn Val Val Ile  Ala Val Leu Met Lys  His Leu Glu 
    1835                 1840                 1845             


Glu Ser  Asn Lys Glu Ala Lys  Glu Glu Ala Glu Leu  Glu Ala Glu 
    1850                 1855                 1860             


Leu Glu  Leu Glu Met Lys Xaa  Leu Ser Pro Gln Pro  His Ser Pro 
    1865                 1870                 1875             


Leu Gly  Ser Pro Phe Leu Trp  Pro Gly Val Glu Gly  Pro Asp Ser 
    1880                 1885                 1890             


Pro Asp  Ser Pro Lys Pro Gly  Ala Leu His Pro Ala  Ala His Ala 
    1895                 1900                 1905             


Arg Ser  Ala Ser His Phe Ser  Leu Glu His Pro Xaa  Met Gln Pro 
    1910                 1915                 1920             


His Pro  Xaa Glu Leu Pro Gly  Pro Asp Leu Leu Xaa  Val Arg Lys 
    1925                 1930                 1935             


Ser Gly  Val Ser Arg Xaa His  Ser Leu Pro Asn Asp  Ser Tyr Met 
    1940                 1945                 1950             


Cys Arg  His Gly Ser Xaa Ala  Glu Gly Pro Leu Gly  His Arg Gly 
    1955                 1960                 1965             


Trp Gly  Leu Pro Lys Ala Gln  Ser Gly Ser Val Leu  Ser Val His 
    1970                 1975                 1980             


Ser Gln  Pro Ala Asp Xaa Ser  Tyr Ile Leu Gln Leu  Pro Lys Asp 
    1985                 1990                 1995             


Ala Pro  His Leu Leu Gln Pro  His Ser Ala Pro Xaa  Trp Gly Xaa 
    2000                 2005                 2010             


Ile Pro  Lys Leu Pro Pro Pro  Gly Arg Ser Pro Leu  Ala Gln Arg 
    2015                 2020                 2025             


Pro Leu  Arg Arg Gln Ala Ala  Ile Arg Xaa Asp Ser  Leu Asp Val 
    2030                 2035                 2040             


Gln Gly  Leu Gly Ser Arg Glu  Asp Leu Leu Ala Glu  Val Ser Gly 
    2045                 2050                 2055             


Pro Ser  Pro Pro Leu Ala Arg  Ala Tyr Ser Phe Trp  Gly Gln Ser 
    2060                 2065                 2070             


Ser Xaa  Gln Ala Gln Gln His  Ser Arg Ser His Ser  Lys Ile Ser 
    2075                 2080                 2085             


Lys His  Met Xaa Pro Pro Ala  Pro Cys Pro Gly Pro  Glu Pro Asn 
    2090                 2095                 2100             


Trp Gly  Lys Gly Pro Pro Glu  Xaa Arg Ser Ser Leu  Glu Leu Asp 
    2105                 2110                 2115             


Xaa Glu  Leu Ser Trp Ile Ser  Gly Asp Leu Leu Pro  Pro Gly Gly 
    2120                 2125                 2130             


Gln Glu  Glu Pro Pro Ser Pro  Arg Asp Leu Lys Lys  Cys Tyr Ser 
    2135                 2140                 2145             


Val Glu  Ala Gln Ser Cys Gln  Arg Arg Pro Xaa Ser  Trp Leu Asp 
    2150                 2155                 2160             


Glu Gln  Arg Arg His Ser Ile  Ala Val Ser Cys Leu  Asp Ser Gly 
    2165                 2170                 2175             


Ser Gln  Pro His Leu Gly Xaa  Asp Pro Ser Asn Leu  Gly Gly Gln 
    2180                 2185                 2190             


Pro Leu  Gly Gly Pro Gly Ser  Arg Pro Lys Lys Lys  Leu Ser Pro 
    2195                 2200                 2205             


Pro Ser  Ile Xaa Ile Asp Pro  Pro Glu Ser Gln Gly  Pro Arg Xaa 
    2210                 2215                 2220             


Pro Pro  Ser Pro Gly Ile Cys  Leu Arg Arg Arg Ala  Pro Ser Ser 
    2225                 2230                 2235             


Asp Ser  Lys Asp Pro Leu Ala  Ser Gly Pro Pro Asp  Ser Met Ala 
    2240                 2245                 2250             


Ala Ser  Pro Ser Pro Lys Lys  Asp Val Leu Ser Leu  Ser Gly Leu 
    2255                 2260                 2265             


Ser Ser  Asp Pro Ala Asp Leu  Asp Pro 
    2270                 2275         


<210> 4717
<211> 2284
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1618)..(1618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1627)..(1627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1651)..(1651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1691)..(1691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1706)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1735)..(1735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1784)..(1784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1794)..(1794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1800)..(1800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1811)..(1811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1820)..(1820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1824)..(1824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1837)..(1837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1877)..(1877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1927)..(1927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1933)..(1933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1942)..(1942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1951)..(1951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1966)..(1966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1996)..(1996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2017)..(2017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2020)..(2020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2045)..(2045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2082)..(2082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2099)..(2099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2118)..(2118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2126)..(2126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2166)..(2166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2192)..(2192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2219)..(2219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2230)..(2230)
<223> Selenocysteine

<400> 4717
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Pro  Ile Met Asn His Asn  Pro Trp Met Leu Leu  Tyr Phe Ile 
    1505                 1510                 1515             


Ser Phe  Leu Leu Ile Val Ala  Phe Phe Val Leu Asn  Met Phe Val 
    1520                 1525                 1530             


Gly Val  Val Val Glu Asn Phe  His Lys Cys Arg Gln  His Gln Glu 
    1535                 1540                 1545             


Glu Glu  Glu Ala Arg Arg Arg  Glu Glu Lys Arg Leu  Arg Arg Leu 
    1550                 1555                 1560             


Glu Lys  Lys Arg Arg Asn Leu  Met Leu Asp Asp Val  Ile Ala Ser 
    1565                 1570                 1575             


Gly Ser  Ser Ala Ser Ala Ala  Ser Glu Ala Gln Cys  Lys Pro Tyr 
    1580                 1585                 1590             


Tyr Ser  Asp Tyr Ser Arg Phe  Arg Leu Leu Val His  His Leu Cys 
    1595                 1600                 1605             


Xaa Ser  His Tyr Leu Asp Leu  Phe Ile Xaa Gly Val  Ile Gly Leu 
    1610                 1615                 1620             


Asn Val  Val Xaa Met Ala Met  Glu His Tyr Gln Gln  Pro Gln Ile 
    1625                 1630                 1635             


Leu Asp  Glu Ala Leu Lys Ile  Cys Asn Tyr Ile Phe  Xaa Val Ile 
    1640                 1645                 1650             


Phe Val  Leu Glu Ser Val Phe  Lys Leu Val Ala Phe  Gly Phe Arg 
    1655                 1660                 1665             


Arg Phe  Phe Gln Asp Arg Trp  Asn Gln Leu Asp Leu  Ala Ile Val 
    1670                 1675                 1680             


Leu Leu  Ser Ile Met Gly Ile  Xaa Leu Glu Glu Ile  Glu Val Asn 
    1685                 1690                 1695             


Ala Ser  Leu Pro Ile Asn Pro  Xaa Ile Ile Arg Ile  Met Arg Val 
    1700                 1705                 1710             


Leu Arg  Ile Ala Arg Val Leu  Lys Leu Leu Lys Met  Ala Val Gly 
    1715                 1720                 1725             


Met Arg  Ala Leu Leu Asp Xaa  Val Met Gln Ala Leu  Pro Gln Val 
    1730                 1735                 1740             


Gly Asn  Leu Gly Leu Leu Phe  Met Leu Leu Phe Phe  Ile Phe Ala 
    1745                 1750                 1755             


Ala Leu  Gly Val Glu Leu Phe  Gly Asp Leu Glu Cys  Asp Glu Xaa 
    1760                 1765                 1770             


His Pro  Cys Glu Gly Leu Gly  Arg His Ala Xaa Phe  Arg Asn Phe 
    1775                 1780                 1785             


Gly Met  Ala Phe Leu Xaa Leu  Phe Arg Val Ser Xaa  Gly Asp Asn 
    1790                 1795                 1800             


Trp Asn  Gly Ile Met Lys Asp  Xaa Leu Arg Asp Cys  Asp Gln Glu 
    1805                 1810                 1815             


Ser Xaa  Cys Tyr Asn Xaa Val  Ile Ser Pro Ile Tyr  Phe Val Ser 
    1820                 1825                 1830             


Phe Val  Leu Xaa Ala Gln Phe  Val Leu Val Asn Val  Val Ile Ala 
    1835                 1840                 1845             


Val Leu  Met Lys His Leu Glu  Glu Ser Asn Lys Glu  Ala Lys Glu 
    1850                 1855                 1860             


Glu Ala  Glu Leu Glu Ala Glu  Leu Glu Leu Glu Met  Lys Xaa Leu 
    1865                 1870                 1875             


Ser Pro  Gln Pro His Ser Pro  Leu Gly Ser Pro Phe  Leu Trp Pro 
    1880                 1885                 1890             


Gly Val  Glu Gly Pro Asp Ser  Pro Asp Ser Pro Lys  Pro Gly Ala 
    1895                 1900                 1905             


Leu His  Pro Ala Ala His Ala  Arg Ser Ala Ser His  Phe Ser Leu 
    1910                 1915                 1920             


Glu His  Pro Xaa Met Gln Pro  His Pro Xaa Glu Leu  Pro Gly Pro 
    1925                 1930                 1935             


Asp Leu  Leu Xaa Val Arg Lys  Ser Gly Val Ser Arg  Xaa His Ser 
    1940                 1945                 1950             


Leu Pro  Asn Asp Ser Tyr Met  Cys Arg His Gly Ser  Xaa Ala Glu 
    1955                 1960                 1965             


Gly Pro  Leu Gly His Arg Gly  Trp Gly Leu Pro Lys  Ala Gln Ser 
    1970                 1975                 1980             


Gly Ser  Val Leu Ser Val His  Ser Gln Pro Ala Asp  Xaa Ser Tyr 
    1985                 1990                 1995             


Ile Leu  Gln Leu Pro Lys Asp  Ala Pro His Leu Leu  Gln Pro His 
    2000                 2005                 2010             


Ser Ala  Pro Xaa Trp Gly Xaa  Ile Pro Lys Leu Pro  Pro Pro Gly 
    2015                 2020                 2025             


Arg Ser  Pro Leu Ala Gln Arg  Pro Leu Arg Arg Gln  Ala Ala Ile 
    2030                 2035                 2040             


Arg Xaa  Asp Ser Leu Asp Val  Gln Gly Leu Gly Ser  Arg Glu Asp 
    2045                 2050                 2055             


Leu Leu  Ala Glu Val Ser Gly  Pro Ser Pro Pro Leu  Ala Arg Ala 
    2060                 2065                 2070             


Tyr Ser  Phe Trp Gly Gln Ser  Ser Xaa Gln Ala Gln  Gln His Ser 
    2075                 2080                 2085             


Arg Ser  His Ser Lys Ile Ser  Lys His Met Xaa Pro  Pro Ala Pro 
    2090                 2095                 2100             


Cys Pro  Gly Pro Glu Pro Asn  Trp Gly Lys Gly Pro  Pro Glu Xaa 
    2105                 2110                 2115             


Arg Ser  Ser Leu Glu Leu Asp  Xaa Glu Leu Ser Trp  Ile Ser Gly 
    2120                 2125                 2130             


Asp Leu  Leu Pro Pro Gly Gly  Gln Glu Glu Pro Pro  Ser Pro Arg 
    2135                 2140                 2145             


Asp Leu  Lys Lys Cys Tyr Ser  Val Glu Ala Gln Ser  Cys Gln Arg 
    2150                 2155                 2160             


Arg Pro  Xaa Ser Trp Leu Asp  Glu Gln Arg Arg His  Ser Ile Ala 
    2165                 2170                 2175             


Val Ser  Cys Leu Asp Ser Gly  Ser Gln Pro His Leu  Gly Xaa Asp 
    2180                 2185                 2190             


Pro Ser  Asn Leu Gly Gly Gln  Pro Leu Gly Gly Pro  Gly Ser Arg 
    2195                 2200                 2205             


Pro Lys  Lys Lys Leu Ser Pro  Pro Ser Ile Xaa Ile  Asp Pro Pro 
    2210                 2215                 2220             


Glu Ser  Gln Gly Pro Arg Xaa  Pro Pro Ser Pro Gly  Ile Cys Leu 
    2225                 2230                 2235             


Arg Arg  Arg Ala Pro Ser Ser  Asp Ser Lys Asp Pro  Leu Ala Ser 
    2240                 2245                 2250             


Gly Pro  Pro Asp Ser Met Ala  Ala Ser Pro Ser Pro  Lys Lys Asp 
    2255                 2260                 2265             


Val Leu  Ser Leu Ser Gly Leu  Ser Ser Asp Pro Ala  Asp Leu Asp 
    2270                 2275                 2280             


Pro 
    


<210> 4718
<211> 2287
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1564)..(1564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1661)..(1661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1690)..(1690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1728)..(1728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1739)..(1739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1749)..(1749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1755)..(1755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1766)..(1766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1775)..(1775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1779)..(1779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1792)..(1792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1832)..(1832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1882)..(1882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1889)..(1889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1936)..(1936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1945)..(1945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1954)..(1954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1969)..(1969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1999)..(1999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2020)..(2020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2023)..(2023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2048)..(2048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2085)..(2085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2102)..(2102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2121)..(2121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2129)..(2129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2169)..(2169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2195)..(2195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2222)..(2222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2233)..(2233)
<223> Selenocysteine

<400> 4718
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Asn  Phe His Lys Cys Arg  Gln His Gln Glu Glu  Glu Glu Ala 
    1505                 1510                 1515             


Arg Arg  Arg Glu Glu Lys Arg  Leu Arg Arg Leu Glu  Lys Lys Arg 
    1520                 1525                 1530             


Arg Ser  Lys Glu Lys Gln Met  Ala Glu Ala Gln Cys  Lys Pro Tyr 
    1535                 1540                 1545             


Tyr Ser  Asp Tyr Ser Arg Phe  Arg Leu Leu Val His  His Leu Cys 
    1550                 1555                 1560             


Xaa Ser  His Tyr Leu Asp Leu  Phe Ile Xaa Gly Val  Ile Gly Leu 
    1565                 1570                 1575             


Asn Val  Val Xaa Met Ala Met  Glu His Tyr Gln Gln  Pro Gln Ile 
    1580                 1585                 1590             


Leu Asp  Glu Ala Leu Lys Ile  Cys Asn Tyr Ile Phe  Xaa Val Ile 
    1595                 1600                 1605             


Phe Val  Leu Glu Ser Val Phe  Lys Leu Val Ala Phe  Gly Phe Arg 
    1610                 1615                 1620             


Arg Phe  Phe Gln Asp Arg Trp  Asn Gln Leu Asp Leu  Ala Ile Val 
    1625                 1630                 1635             


Leu Leu  Ser Ile Met Gly Ile  Xaa Leu Glu Glu Ile  Glu Val Asn 
    1640                 1645                 1650             


Ala Ser  Leu Pro Ile Asn Pro  Xaa Ile Ile Arg Ile  Met Arg Val 
    1655                 1660                 1665             


Leu Arg  Ile Ala Arg Val Leu  Lys Leu Leu Lys Met  Ala Val Gly 
    1670                 1675                 1680             


Met Arg  Ala Leu Leu Asp Xaa  Val Met Gln Ala Leu  Pro Gln Val 
    1685                 1690                 1695             


Gly Asn  Leu Gly Leu Leu Phe  Met Leu Leu Phe Phe  Ile Phe Ala 
    1700                 1705                 1710             


Ala Leu  Gly Val Glu Leu Phe  Gly Asp Leu Glu Cys  Asp Glu Xaa 
    1715                 1720                 1725             


His Pro  Cys Glu Gly Leu Gly  Arg His Ala Xaa Phe  Arg Asn Phe 
    1730                 1735                 1740             


Gly Met  Ala Phe Leu Xaa Leu  Phe Arg Val Ser Xaa  Gly Asp Asn 
    1745                 1750                 1755             


Trp Asn  Gly Ile Met Lys Asp  Xaa Leu Arg Asp Cys  Asp Gln Glu 
    1760                 1765                 1770             


Ser Xaa  Cys Tyr Asn Xaa Val  Ile Ser Pro Ile Tyr  Phe Val Ser 
    1775                 1780                 1785             


Phe Val  Leu Xaa Ala Gln Phe  Val Leu Val Asn Val  Val Ile Ala 
    1790                 1795                 1800             


Val Leu  Met Lys His Leu Glu  Glu Ser Asn Lys Glu  Ala Lys Glu 
    1805                 1810                 1815             


Glu Ala  Glu Leu Glu Ala Glu  Leu Glu Leu Glu Met  Lys Xaa Leu 
    1820                 1825                 1830             


Ser Pro  Gln Pro His Ser Pro  Leu Gly Ser Pro Phe  Leu Trp Pro 
    1835                 1840                 1845             


Gly Val  Glu Gly Pro Asp Ser  Pro Asp Ser Pro Lys  Pro Gly Ala 
    1850                 1855                 1860             


Leu His  Pro Ala Ala His Ala  Arg Ser Ala Ser His  Phe Ser Leu 
    1865                 1870                 1875             


Glu His  Pro Xaa Asp Arg Gln  Leu Phe Asp Xaa Ile  Ser Leu Leu 
    1880                 1885                 1890             


Ile Gln  Gly Ser Leu Glu Trp  Glu Leu Lys Leu Met  Asp Glu Leu 
    1895                 1900                 1905             


Ala Gly  Pro Gly Gly Gln Pro  Ser Ala Phe Pro Ser  Ala Pro Ser 
    1910                 1915                 1920             


Leu Gly  Gly Ser Asp Pro Gln  Met Gln Pro His Pro  Xaa Glu Leu 
    1925                 1930                 1935             


Pro Gly  Pro Asp Leu Leu Xaa  Val Arg Lys Ser Gly  Val Ser Arg 
    1940                 1945                 1950             


Xaa His  Ser Leu Pro Asn Asp  Ser Tyr Met Cys Arg  His Gly Ser 
    1955                 1960                 1965             


Xaa Ala  Glu Gly Pro Leu Gly  His Arg Gly Trp Gly  Leu Pro Lys 
    1970                 1975                 1980             


Ala Gln  Ser Gly Ser Val Leu  Ser Val His Ser Gln  Pro Ala Asp 
    1985                 1990                 1995             


Xaa Ser  Tyr Ile Leu Gln Leu  Pro Lys Asp Ala Pro  His Leu Leu 
    2000                 2005                 2010             


Gln Pro  His Ser Ala Pro Xaa  Trp Gly Xaa Ile Pro  Lys Leu Pro 
    2015                 2020                 2025             


Pro Pro  Gly Arg Ser Pro Leu  Ala Gln Arg Pro Leu  Arg Arg Gln 
    2030                 2035                 2040             


Ala Ala  Ile Arg Xaa Asp Ser  Leu Asp Val Gln Gly  Leu Gly Ser 
    2045                 2050                 2055             


Arg Glu  Asp Leu Leu Ala Glu  Val Ser Gly Pro Ser  Pro Pro Leu 
    2060                 2065                 2070             


Ala Arg  Ala Tyr Ser Phe Trp  Gly Gln Ser Ser Xaa  Gln Ala Gln 
    2075                 2080                 2085             


Gln His  Ser Arg Ser His Ser  Lys Ile Ser Lys His  Met Xaa Pro 
    2090                 2095                 2100             


Pro Ala  Pro Cys Pro Gly Pro  Glu Pro Asn Trp Gly  Lys Gly Pro 
    2105                 2110                 2115             


Pro Glu  Xaa Arg Ser Ser Leu  Glu Leu Asp Xaa Glu  Leu Ser Trp 
    2120                 2125                 2130             


Ile Ser  Gly Asp Leu Leu Pro  Pro Gly Gly Gln Glu  Glu Pro Pro 
    2135                 2140                 2145             


Ser Pro  Arg Asp Leu Lys Lys  Cys Tyr Ser Val Glu  Ala Gln Ser 
    2150                 2155                 2160             


Cys Gln  Arg Arg Pro Xaa Ser  Trp Leu Asp Glu Gln  Arg Arg His 
    2165                 2170                 2175             


Ser Ile  Ala Val Ser Cys Leu  Asp Ser Gly Ser Gln  Pro His Leu 
    2180                 2185                 2190             


Gly Xaa  Asp Pro Ser Asn Leu  Gly Gly Gln Pro Leu  Gly Gly Pro 
    2195                 2200                 2205             


Gly Ser  Arg Pro Lys Lys Lys  Leu Ser Pro Pro Ser  Ile Xaa Ile 
    2210                 2215                 2220             


Asp Pro  Pro Glu Ser Gln Gly  Pro Arg Xaa Pro Pro  Ser Pro Gly 
    2225                 2230                 2235             


Ile Cys  Leu Arg Arg Arg Ala  Pro Ser Ser Asp Ser  Lys Asp Pro 
    2240                 2245                 2250             


Leu Ala  Ser Gly Pro Pro Asp  Ser Met Ala Ala Ser  Pro Ser Pro 
    2255                 2260                 2265             


Lys Lys  Asp Val Leu Ser Leu  Ser Gly Leu Ser Ser  Asp Pro Ala 
    2270                 2275                 2280             


Asp Leu  Asp Pro 
    2285         


<210> 4719
<211> 2291
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1616)..(1616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1625)..(1625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1634)..(1634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1658)..(1658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1698)..(1698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1713)..(1713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1742)..(1742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1780)..(1780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1791)..(1791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1801)..(1801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1807)..(1807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1818)..(1818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1827)..(1827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1831)..(1831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1844)..(1844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1884)..(1884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1934)..(1934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1940)..(1940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1949)..(1949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1958)..(1958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1973)..(1973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2003)..(2003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2024)..(2024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2027)..(2027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2052)..(2052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2089)..(2089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2106)..(2106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2125)..(2125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2133)..(2133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2173)..(2173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2199)..(2199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2226)..(2226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2237)..(2237)
<223> Selenocysteine

<400> 4719
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Pro  Ile Met Asn His Asn  Pro Trp Met Leu Leu  Tyr Phe Ile 
    1505                 1510                 1515             


Ser Phe  Leu Leu Ile Val Ala  Phe Phe Val Leu Asn  Met Phe Val 
    1520                 1525                 1530             


Gly Val  Val Val Glu Asn Phe  His Lys Cys Arg Gln  His Gln Glu 
    1535                 1540                 1545             


Glu Glu  Glu Ala Arg Arg Arg  Glu Glu Lys Arg Leu  Arg Arg Leu 
    1550                 1555                 1560             


Glu Lys  Lys Arg Arg Ser Lys  Glu Lys Gln Met Ala  Asp Leu Met 
    1565                 1570                 1575             


Leu Asp  Asp Val Ile Ala Ser  Gly Ser Ser Ala Ser  Ala Ala Ser 
    1580                 1585                 1590             


Glu Ala  Gln Cys Lys Pro Tyr  Tyr Ser Asp Tyr Ser  Arg Phe Arg 
    1595                 1600                 1605             


Leu Leu  Val His His Leu Cys  Xaa Ser His Tyr Leu  Asp Leu Phe 
    1610                 1615                 1620             


Ile Xaa  Gly Val Ile Gly Leu  Asn Val Val Xaa Met  Ala Met Glu 
    1625                 1630                 1635             


His Tyr  Gln Gln Pro Gln Ile  Leu Asp Glu Ala Leu  Lys Ile Cys 
    1640                 1645                 1650             


Asn Tyr  Ile Phe Xaa Val Ile  Phe Val Leu Glu Ser  Val Phe Lys 
    1655                 1660                 1665             


Leu Val  Ala Phe Gly Phe Arg  Arg Phe Phe Gln Asp  Arg Trp Asn 
    1670                 1675                 1680             


Gln Leu  Asp Leu Ala Ile Val  Leu Leu Ser Ile Met  Gly Ile Xaa 
    1685                 1690                 1695             


Leu Glu  Glu Ile Glu Val Asn  Ala Ser Leu Pro Ile  Asn Pro Xaa 
    1700                 1705                 1710             


Ile Ile  Arg Ile Met Arg Val  Leu Arg Ile Ala Arg  Val Leu Lys 
    1715                 1720                 1725             


Leu Leu  Lys Met Ala Val Gly  Met Arg Ala Leu Leu  Asp Xaa Val 
    1730                 1735                 1740             


Met Gln  Ala Leu Pro Gln Val  Gly Asn Leu Gly Leu  Leu Phe Met 
    1745                 1750                 1755             


Leu Leu  Phe Phe Ile Phe Ala  Ala Leu Gly Val Glu  Leu Phe Gly 
    1760                 1765                 1770             


Asp Leu  Glu Cys Asp Glu Xaa  His Pro Cys Glu Gly  Leu Gly Arg 
    1775                 1780                 1785             


His Ala  Xaa Phe Arg Asn Phe  Gly Met Ala Phe Leu  Xaa Leu Phe 
    1790                 1795                 1800             


Arg Val  Ser Xaa Gly Asp Asn  Trp Asn Gly Ile Met  Lys Asp Xaa 
    1805                 1810                 1815             


Leu Arg  Asp Cys Asp Gln Glu  Ser Xaa Cys Tyr Asn  Xaa Val Ile 
    1820                 1825                 1830             


Ser Pro  Ile Tyr Phe Val Ser  Phe Val Leu Xaa Ala  Gln Phe Val 
    1835                 1840                 1845             


Leu Val  Asn Val Val Ile Ala  Val Leu Met Lys His  Leu Glu Glu 
    1850                 1855                 1860             


Ser Asn  Lys Glu Ala Lys Glu  Glu Ala Glu Leu Glu  Ala Glu Leu 
    1865                 1870                 1875             


Glu Leu  Glu Met Lys Xaa Leu  Ser Pro Gln Pro His  Ser Pro Leu 
    1880                 1885                 1890             


Gly Ser  Pro Phe Leu Trp Pro  Gly Val Glu Gly Pro  Asp Ser Pro 
    1895                 1900                 1905             


Asp Ser  Pro Lys Pro Gly Ala  Leu His Pro Ala Ala  His Ala Arg 
    1910                 1915                 1920             


Ser Ala  Ser His Phe Ser Leu  Glu His Pro Xaa Met  Gln Pro His 
    1925                 1930                 1935             


Pro Xaa  Glu Leu Pro Gly Pro  Asp Leu Leu Xaa Val  Arg Lys Ser 
    1940                 1945                 1950             


Gly Val  Ser Arg Xaa His Ser  Leu Pro Asn Asp Ser  Tyr Met Cys 
    1955                 1960                 1965             


Arg His  Gly Ser Xaa Ala Glu  Gly Pro Leu Gly His  Arg Gly Trp 
    1970                 1975                 1980             


Gly Leu  Pro Lys Ala Gln Ser  Gly Ser Val Leu Ser  Val His Ser 
    1985                 1990                 1995             


Gln Pro  Ala Asp Xaa Ser Tyr  Ile Leu Gln Leu Pro  Lys Asp Ala 
    2000                 2005                 2010             


Pro His  Leu Leu Gln Pro His  Ser Ala Pro Xaa Trp  Gly Xaa Ile 
    2015                 2020                 2025             


Pro Lys  Leu Pro Pro Pro Gly  Arg Ser Pro Leu Ala  Gln Arg Pro 
    2030                 2035                 2040             


Leu Arg  Arg Gln Ala Ala Ile  Arg Xaa Asp Ser Leu  Asp Val Gln 
    2045                 2050                 2055             


Gly Leu  Gly Ser Arg Glu Asp  Leu Leu Ala Glu Val  Ser Gly Pro 
    2060                 2065                 2070             


Ser Pro  Pro Leu Ala Arg Ala  Tyr Ser Phe Trp Gly  Gln Ser Ser 
    2075                 2080                 2085             


Xaa Gln  Ala Gln Gln His Ser  Arg Ser His Ser Lys  Ile Ser Lys 
    2090                 2095                 2100             


His Met  Xaa Pro Pro Ala Pro  Cys Pro Gly Pro Glu  Pro Asn Trp 
    2105                 2110                 2115             


Gly Lys  Gly Pro Pro Glu Xaa  Arg Ser Ser Leu Glu  Leu Asp Xaa 
    2120                 2125                 2130             


Glu Leu  Ser Trp Ile Ser Gly  Asp Leu Leu Pro Pro  Gly Gly Gln 
    2135                 2140                 2145             


Glu Glu  Pro Pro Ser Pro Arg  Asp Leu Lys Lys Cys  Tyr Ser Val 
    2150                 2155                 2160             


Glu Ala  Gln Ser Cys Gln Arg  Arg Pro Xaa Ser Trp  Leu Asp Glu 
    2165                 2170                 2175             


Gln Arg  Arg His Ser Ile Ala  Val Ser Cys Leu Asp  Ser Gly Ser 
    2180                 2185                 2190             


Gln Pro  His Leu Gly Xaa Asp  Pro Ser Asn Leu Gly  Gly Gln Pro 
    2195                 2200                 2205             


Leu Gly  Gly Pro Gly Ser Arg  Pro Lys Lys Lys Leu  Ser Pro Pro 
    2210                 2215                 2220             


Ser Ile  Xaa Ile Asp Pro Pro  Glu Ser Gln Gly Pro  Arg Xaa Pro 
    2225                 2230                 2235             


Pro Ser  Pro Gly Ile Cys Leu  Arg Arg Arg Ala Pro  Ser Ser Asp 
    2240                 2245                 2250             


Ser Lys  Asp Pro Leu Ala Ser  Gly Pro Pro Asp Ser  Met Ala Ala 
    2255                 2260                 2265             


Ser Pro  Ser Pro Lys Lys Asp  Val Leu Ser Leu Ser  Gly Leu Ser 
    2270                 2275                 2280             


Ser Asp  Pro Ala Asp Leu Asp  Pro 
    2285                 2290     


<210> 4720
<211> 2298
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1575)..(1575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1584)..(1584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1593)..(1593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1617)..(1617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1672)..(1672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1701)..(1701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1739)..(1739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1750)..(1750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1766)..(1766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1777)..(1777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1786)..(1786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1803)..(1803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1843)..(1843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1893)..(1893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1900)..(1900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1947)..(1947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1956)..(1956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1965)..(1965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1980)..(1980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2010)..(2010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2031)..(2031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2034)..(2034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2059)..(2059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2096)..(2096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2113)..(2113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2132)..(2132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2140)..(2140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2180)..(2180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2206)..(2206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2233)..(2233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2244)..(2244)
<223> Selenocysteine

<400> 4720
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Gly Asp Ala Asn Lys Ser 
                965                 970                 975     


Glu Ser Glu Pro Asp Phe Phe Ser Pro Ser Leu Asp Gly Asp Gly Asp 
            980                 985                 990         


Arg Lys Lys Cys Leu Ala Leu Val  Ser Leu Gly Glu His  Pro Glu Leu 
        995                 1000                 1005             


Arg Lys  Ser Leu Leu Pro Pro  Leu Ile Ile His Xaa  Ala Ala Xaa 
    1010                 1015                 1020             


Pro Met  Ser Leu Pro Lys Ser  Xaa Ser Xaa Gly Leu  Gly Glu Ala 
    1025                 1030                 1035             


Leu Gly  Pro Ala Ser Arg Arg  Xaa Ser Ser Ser Gly  Ser Ala Glu 
    1040                 1045                 1050             


Pro Gly  Ala Ala His Glu Met  Lys Ser Pro Pro Ser  Ala Arg Ser 
    1055                 1060                 1065             


Ser Pro  His Ser Pro Trp Ser  Ala Ala Ser Ser Trp  Xaa Ser Arg 
    1070                 1075                 1080             


Arg Ser  Ser Arg Asn Ser Leu  Gly Arg Ala Pro Ser  Leu Lys Arg 
    1085                 1090                 1095             


Arg Ser  Pro Ser Gly Glu Arg  Arg Ser Leu Leu Ser  Gly Glu Gly 
    1100                 1105                 1110             


Gln Glu  Ser Gln Asp Glu Glu  Glu Ser Ser Glu Glu  Glu Arg Ala 
    1115                 1120                 1125             


Ser Pro  Ala Gly Ser Asp His  Arg His Arg Gly Ser  Leu Glu Arg 
    1130                 1135                 1140             


Glu Ala  Lys Ser Ser Phe Asp  Leu Pro Asp Xaa Leu  Gln Val Pro 
    1145                 1150                 1155             


Gly Leu  His Arg Xaa Ala Ser  Gly Arg Gly Ser Ala  Ser Glu His 
    1160                 1165                 1170             


Gln Asp  Cys Asn Gly Lys Ser  Ala Ser Gly Arg Leu  Ala Arg Ala 
    1175                 1180                 1185             


Leu Arg  Pro Asp Asp Pro Pro  Leu Asp Gly Asp Asp  Ala Asp Asp 
    1190                 1195                 1200             


Glu Gly  Asn Leu Ser Lys Gly  Glu Arg Val Arg Ala  Trp Ile Arg 
    1205                 1210                 1215             


Ala Arg  Leu Pro Ala Cys Cys  Leu Glu Arg Asp Ser  Trp Ser Ala 
    1220                 1225                 1230             


Tyr Ile  Phe Pro Pro Gln Ser  Arg Phe Arg Leu Leu  Cys His Arg 
    1235                 1240                 1245             


Ile Ile  Xaa His Lys Met Phe  Asp His Val Val Leu  Val Ile Ile 
    1250                 1255                 1260             


Phe Leu  Asn Cys Ile Xaa Ile  Ala Met Glu Arg Pro  Lys Ile Asp 
    1265                 1270                 1275             


Pro His  Ser Ala Glu Arg Ile  Phe Leu Xaa Leu Ser  Asn Tyr Ile 
    1280                 1285                 1290             


Phe Xaa  Ala Val Phe Leu Ala  Glu Met Xaa Val Lys  Val Val Ala 
    1295                 1300                 1305             


Leu Gly  Trp Cys Phe Gly Glu  Gln Ala Tyr Leu Arg  Ser Ser Trp 
    1310                 1315                 1320             


Asn Val  Leu Asp Gly Leu Leu  Val Leu Ile Ser Val  Ile Asp Ile 
    1325                 1330                 1335             


Leu Val  Ser Met Val Ser Asp  Ser Gly Xaa Lys Ile  Leu Gly Met 
    1340                 1345                 1350             


Leu Arg  Val Leu Arg Leu Leu  Arg Xaa Leu Arg Pro  Leu Arg Val 
    1355                 1360                 1365             


Ile Ser  Arg Ala Gln Gly Leu  Lys Leu Val Val Glu  Xaa Leu Met 
    1370                 1375                 1380             


Ser Ser  Leu Lys Pro Ile Gly  Asn Ile Val Val Ile  Cys Cys Ala 
    1385                 1390                 1395             


Phe Phe  Ile Ile Phe Gly Ile  Leu Gly Val Gln Leu  Phe Lys Gly 
    1400                 1405                 1410             


Lys Phe  Phe Val Cys Gln Gly  Glu Asp Xaa Arg Asn  Ile Xaa Asn 
    1415                 1420                 1425             


Lys Ser  Asp Cys Ala Glu Ala  Ser Tyr Arg Trp Val  Arg His Lys 
    1430                 1435                 1440             


Tyr Asn  Phe Asp Asn Leu Gly  Gln Ala Leu Met Ser  Leu Phe Val 
    1445                 1450                 1455             


Leu Ala  Ser Lys Asp Gly Trp  Val Asp Ile Met Tyr  Asp Gly Leu 
    1460                 1465                 1470             


Asp Ala  Val Gly Val Asp Gln  Gln Pro Ile Met Asn  His Asn Pro 
    1475                 1480                 1485             


Trp Met  Leu Leu Tyr Phe Ile  Ser Phe Leu Leu Ile  Val Ala Phe 
    1490                 1495                 1500             


Phe Val  Leu Asn Met Phe Val  Gly Val Val Val Glu  Asn Phe His 
    1505                 1510                 1515             


Lys Cys  Arg Gln His Gln Glu  Glu Glu Glu Ala Arg  Arg Arg Glu 
    1520                 1525                 1530             


Glu Lys  Arg Leu Arg Arg Leu  Glu Lys Lys Arg Arg  Ser Lys Glu 
    1535                 1540                 1545             


Lys Gln  Met Ala Glu Ala Gln  Cys Lys Pro Tyr Tyr  Ser Asp Tyr 
    1550                 1555                 1560             


Ser Arg  Phe Arg Leu Leu Val  His His Leu Cys Xaa  Ser His Tyr 
    1565                 1570                 1575             


Leu Asp  Leu Phe Ile Xaa Gly  Val Ile Gly Leu Asn  Val Val Xaa 
    1580                 1585                 1590             


Met Ala  Met Glu His Tyr Gln  Gln Pro Gln Ile Leu  Asp Glu Ala 
    1595                 1600                 1605             


Leu Lys  Ile Cys Asn Tyr Ile  Phe Xaa Val Ile Phe  Val Leu Glu 
    1610                 1615                 1620             


Ser Val  Phe Lys Leu Val Ala  Phe Gly Phe Arg Arg  Phe Phe Gln 
    1625                 1630                 1635             


Asp Arg  Trp Asn Gln Leu Asp  Leu Ala Ile Val Leu  Leu Ser Ile 
    1640                 1645                 1650             


Met Gly  Ile Xaa Leu Glu Glu  Ile Glu Val Asn Ala  Ser Leu Pro 
    1655                 1660                 1665             


Ile Asn  Pro Xaa Ile Ile Arg  Ile Met Arg Val Leu  Arg Ile Ala 
    1670                 1675                 1680             


Arg Val  Leu Lys Leu Leu Lys  Met Ala Val Gly Met  Arg Ala Leu 
    1685                 1690                 1695             


Leu Asp  Xaa Val Met Gln Ala  Leu Pro Gln Val Gly  Asn Leu Gly 
    1700                 1705                 1710             


Leu Leu  Phe Met Leu Leu Phe  Phe Ile Phe Ala Ala  Leu Gly Val 
    1715                 1720                 1725             


Glu Leu  Phe Gly Asp Leu Glu  Cys Asp Glu Xaa His  Pro Cys Glu 
    1730                 1735                 1740             


Gly Leu  Gly Arg His Ala Xaa  Phe Arg Asn Phe Gly  Met Ala Phe 
    1745                 1750                 1755             


Leu Xaa  Leu Phe Arg Val Ser  Xaa Gly Asp Asn Trp  Asn Gly Ile 
    1760                 1765                 1770             


Met Lys  Asp Xaa Leu Arg Asp  Cys Asp Gln Glu Ser  Xaa Cys Tyr 
    1775                 1780                 1785             


Asn Xaa  Val Ile Ser Pro Ile  Tyr Phe Val Ser Phe  Val Leu Xaa 
    1790                 1795                 1800             


Ala Gln  Phe Val Leu Val Asn  Val Val Ile Ala Val  Leu Met Lys 
    1805                 1810                 1815             


His Leu  Glu Glu Ser Asn Lys  Glu Ala Lys Glu Glu  Ala Glu Leu 
    1820                 1825                 1830             


Glu Ala  Glu Leu Glu Leu Glu  Met Lys Xaa Leu Ser  Pro Gln Pro 
    1835                 1840                 1845             


His Ser  Pro Leu Gly Ser Pro  Phe Leu Trp Pro Gly  Val Glu Gly 
    1850                 1855                 1860             


Pro Asp  Ser Pro Asp Ser Pro  Lys Pro Gly Ala Leu  His Pro Ala 
    1865                 1870                 1875             


Ala His  Ala Arg Ser Ala Ser  His Phe Ser Leu Glu  His Pro Xaa 
    1880                 1885                 1890             


Asp Arg  Gln Leu Phe Asp Xaa  Ile Ser Leu Leu Ile  Gln Gly Ser 
    1895                 1900                 1905             


Leu Glu  Trp Glu Leu Lys Leu  Met Asp Glu Leu Ala  Gly Pro Gly 
    1910                 1915                 1920             


Gly Gln  Pro Ser Ala Phe Pro  Ser Ala Pro Ser Leu  Gly Gly Ser 
    1925                 1930                 1935             


Asp Pro  Gln Met Gln Pro His  Pro Xaa Glu Leu Pro  Gly Pro Asp 
    1940                 1945                 1950             


Leu Leu  Xaa Val Arg Lys Ser  Gly Val Ser Arg Xaa  His Ser Leu 
    1955                 1960                 1965             


Pro Asn  Asp Ser Tyr Met Cys  Arg His Gly Ser Xaa  Ala Glu Gly 
    1970                 1975                 1980             


Pro Leu  Gly His Arg Gly Trp  Gly Leu Pro Lys Ala  Gln Ser Gly 
    1985                 1990                 1995             


Ser Val  Leu Ser Val His Ser  Gln Pro Ala Asp Xaa  Ser Tyr Ile 
    2000                 2005                 2010             


Leu Gln  Leu Pro Lys Asp Ala  Pro His Leu Leu Gln  Pro His Ser 
    2015                 2020                 2025             


Ala Pro  Xaa Trp Gly Xaa Ile  Pro Lys Leu Pro Pro  Pro Gly Arg 
    2030                 2035                 2040             


Ser Pro  Leu Ala Gln Arg Pro  Leu Arg Arg Gln Ala  Ala Ile Arg 
    2045                 2050                 2055             


Xaa Asp  Ser Leu Asp Val Gln  Gly Leu Gly Ser Arg  Glu Asp Leu 
    2060                 2065                 2070             


Leu Ala  Glu Val Ser Gly Pro  Ser Pro Pro Leu Ala  Arg Ala Tyr 
    2075                 2080                 2085             


Ser Phe  Trp Gly Gln Ser Ser  Xaa Gln Ala Gln Gln  His Ser Arg 
    2090                 2095                 2100             


Ser His  Ser Lys Ile Ser Lys  His Met Xaa Pro Pro  Ala Pro Cys 
    2105                 2110                 2115             


Pro Gly  Pro Glu Pro Asn Trp  Gly Lys Gly Pro Pro  Glu Xaa Arg 
    2120                 2125                 2130             


Ser Ser  Leu Glu Leu Asp Xaa  Glu Leu Ser Trp Ile  Ser Gly Asp 
    2135                 2140                 2145             


Leu Leu  Pro Pro Gly Gly Gln  Glu Glu Pro Pro Ser  Pro Arg Asp 
    2150                 2155                 2160             


Leu Lys  Lys Cys Tyr Ser Val  Glu Ala Gln Ser Cys  Gln Arg Arg 
    2165                 2170                 2175             


Pro Xaa  Ser Trp Leu Asp Glu  Gln Arg Arg His Ser  Ile Ala Val 
    2180                 2185                 2190             


Ser Cys  Leu Asp Ser Gly Ser  Gln Pro His Leu Gly  Xaa Asp Pro 
    2195                 2200                 2205             


Ser Asn  Leu Gly Gly Gln Pro  Leu Gly Gly Pro Gly  Ser Arg Pro 
    2210                 2215                 2220             


Lys Lys  Lys Leu Ser Pro Pro  Ser Ile Xaa Ile Asp  Pro Pro Glu 
    2225                 2230                 2235             


Ser Gln  Gly Pro Arg Xaa Pro  Pro Ser Pro Gly Ile  Cys Leu Arg 
    2240                 2245                 2250             


Arg Arg  Ala Pro Ser Ser Asp  Ser Lys Asp Pro Leu  Ala Ser Gly 
    2255                 2260                 2265             


Pro Pro  Asp Ser Met Ala Ala  Ser Pro Ser Pro Lys  Lys Asp Val 
    2270                 2275                 2280             


Leu Ser  Leu Ser Gly Leu Ser  Ser Asp Pro Ala Asp  Leu Asp Pro 
    2285                 2290                 2295             


<210> 4721
<211> 2306
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1595)..(1595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1604)..(1604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1628)..(1628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1668)..(1668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1683)..(1683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1712)..(1712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1750)..(1750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1771)..(1771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1777)..(1777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1788)..(1788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1797)..(1797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1801)..(1801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1814)..(1814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1854)..(1854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1904)..(1904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1916)..(1916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1930)..(1930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1940)..(1940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1955)..(1955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1964)..(1964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1973)..(1973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1988)..(1988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2018)..(2018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2039)..(2039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2042)..(2042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2067)..(2067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2104)..(2104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2121)..(2121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2140)..(2140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2148)..(2148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2188)..(2188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2214)..(2214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2241)..(2241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2252)..(2252)
<223> Selenocysteine

<400> 4721
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Gly Asp Ala Asn Lys Ser 
                965                 970                 975     


Glu Ser Glu Pro Asp Phe Phe Ser Pro Ser Leu Asp Gly Asp Gly Asp 
            980                 985                 990         


Arg Lys Lys Cys Leu Ala Leu Val  Ser Leu Gly Glu His  Pro Glu Leu 
        995                 1000                 1005             


Arg Lys  Ser Leu Leu Pro Pro  Leu Ile Ile His Xaa  Ala Ala Xaa 
    1010                 1015                 1020             


Pro Met  Ser Leu Pro Lys Ser  Xaa Ser Xaa Gly Leu  Gly Glu Ala 
    1025                 1030                 1035             


Leu Gly  Pro Ala Ser Arg Arg  Xaa Ser Ser Ser Gly  Ser Ala Glu 
    1040                 1045                 1050             


Pro Gly  Ala Ala His Glu Met  Lys Ser Pro Pro Ser  Ala Arg Ser 
    1055                 1060                 1065             


Ser Pro  His Ser Pro Trp Ser  Ala Ala Ser Ser Trp  Xaa Ser Arg 
    1070                 1075                 1080             


Arg Ser  Ser Arg Asn Ser Leu  Gly Arg Ala Pro Ser  Leu Lys Arg 
    1085                 1090                 1095             


Arg Ser  Pro Ser Gly Glu Arg  Arg Ser Leu Leu Ser  Gly Glu Gly 
    1100                 1105                 1110             


Gln Glu  Ser Gln Asp Glu Glu  Glu Ser Ser Glu Glu  Glu Arg Ala 
    1115                 1120                 1125             


Ser Pro  Ala Gly Ser Asp His  Arg His Arg Gly Ser  Leu Glu Arg 
    1130                 1135                 1140             


Glu Ala  Lys Ser Ser Phe Asp  Leu Pro Asp Xaa Leu  Gln Val Pro 
    1145                 1150                 1155             


Gly Leu  His Arg Xaa Ala Ser  Gly Arg Gly Ser Ala  Ser Glu His 
    1160                 1165                 1170             


Gln Asp  Cys Asn Gly Lys Ser  Ala Ser Gly Arg Leu  Ala Arg Ala 
    1175                 1180                 1185             


Leu Arg  Pro Asp Asp Pro Pro  Leu Asp Gly Asp Asp  Ala Asp Asp 
    1190                 1195                 1200             


Glu Gly  Asn Leu Ser Lys Gly  Glu Arg Val Arg Ala  Trp Ile Arg 
    1205                 1210                 1215             


Ala Arg  Leu Pro Ala Cys Cys  Leu Glu Arg Asp Ser  Trp Ser Ala 
    1220                 1225                 1230             


Tyr Ile  Phe Pro Pro Gln Ser  Arg Phe Arg Leu Leu  Cys His Arg 
    1235                 1240                 1245             


Ile Ile  Xaa His Lys Met Phe  Asp His Val Val Leu  Val Ile Ile 
    1250                 1255                 1260             


Phe Leu  Asn Cys Ile Xaa Ile  Ala Met Glu Arg Pro  Lys Ile Asp 
    1265                 1270                 1275             


Pro His  Ser Ala Glu Arg Ile  Phe Leu Xaa Leu Ser  Asn Tyr Ile 
    1280                 1285                 1290             


Phe Xaa  Ala Val Phe Leu Ala  Glu Met Xaa Val Lys  Val Val Ala 
    1295                 1300                 1305             


Leu Gly  Trp Cys Phe Gly Glu  Gln Ala Tyr Leu Arg  Ser Ser Trp 
    1310                 1315                 1320             


Asn Val  Leu Asp Gly Leu Leu  Val Leu Ile Ser Val  Ile Asp Ile 
    1325                 1330                 1335             


Leu Val  Ser Met Val Ser Asp  Ser Gly Xaa Lys Ile  Leu Gly Met 
    1340                 1345                 1350             


Leu Arg  Val Leu Arg Leu Leu  Arg Xaa Leu Arg Pro  Leu Arg Val 
    1355                 1360                 1365             


Ile Ser  Arg Ala Gln Gly Leu  Lys Leu Val Val Glu  Xaa Leu Met 
    1370                 1375                 1380             


Ser Ser  Leu Lys Pro Ile Gly  Asn Ile Val Val Ile  Cys Cys Ala 
    1385                 1390                 1395             


Phe Phe  Ile Ile Phe Gly Ile  Leu Gly Val Gln Leu  Phe Lys Gly 
    1400                 1405                 1410             


Lys Phe  Phe Val Cys Gln Gly  Glu Asp Xaa Arg Asn  Ile Xaa Asn 
    1415                 1420                 1425             


Lys Ser  Asp Cys Ala Glu Ala  Ser Tyr Arg Trp Val  Arg His Lys 
    1430                 1435                 1440             


Tyr Asn  Phe Asp Asn Leu Gly  Gln Ala Leu Met Ser  Leu Phe Val 
    1445                 1450                 1455             


Leu Ala  Ser Lys Asp Gly Trp  Val Asp Ile Met Tyr  Asp Gly Leu 
    1460                 1465                 1470             


Asp Ala  Val Gly Val Asp Gln  Gln Pro Ile Met Asn  His Asn Pro 
    1475                 1480                 1485             


Trp Met  Leu Leu Tyr Phe Ile  Ser Phe Leu Leu Ile  Val Ala Phe 
    1490                 1495                 1500             


Phe Val  Leu Asn Met Phe Val  Gly Val Val Val Glu  Asn Phe His 
    1505                 1510                 1515             


Lys Cys  Arg Gln His Gln Glu  Glu Glu Glu Ala Arg  Arg Arg Glu 
    1520                 1525                 1530             


Glu Lys  Arg Leu Arg Arg Leu  Glu Lys Lys Arg Arg  Asn Leu Met 
    1535                 1540                 1545             


Leu Asp  Asp Val Ile Ala Ser  Gly Ser Ser Ala Ser  Ala Ala Ser 
    1550                 1555                 1560             


Glu Ala  Gln Cys Lys Pro Tyr  Tyr Ser Asp Tyr Ser  Arg Phe Arg 
    1565                 1570                 1575             


Leu Leu  Val His His Leu Cys  Xaa Ser His Tyr Leu  Asp Leu Phe 
    1580                 1585                 1590             


Ile Xaa  Gly Val Ile Gly Leu  Asn Val Val Xaa Met  Ala Met Glu 
    1595                 1600                 1605             


His Tyr  Gln Gln Pro Gln Ile  Leu Asp Glu Ala Leu  Lys Ile Cys 
    1610                 1615                 1620             


Asn Tyr  Ile Phe Xaa Val Ile  Phe Val Leu Glu Ser  Val Phe Lys 
    1625                 1630                 1635             


Leu Val  Ala Phe Gly Phe Arg  Arg Phe Phe Gln Asp  Arg Trp Asn 
    1640                 1645                 1650             


Gln Leu  Asp Leu Ala Ile Val  Leu Leu Ser Ile Met  Gly Ile Xaa 
    1655                 1660                 1665             


Leu Glu  Glu Ile Glu Val Asn  Ala Ser Leu Pro Ile  Asn Pro Xaa 
    1670                 1675                 1680             


Ile Ile  Arg Ile Met Arg Val  Leu Arg Ile Ala Arg  Val Leu Lys 
    1685                 1690                 1695             


Leu Leu  Lys Met Ala Val Gly  Met Arg Ala Leu Leu  Asp Xaa Val 
    1700                 1705                 1710             


Met Gln  Ala Leu Pro Gln Val  Gly Asn Leu Gly Leu  Leu Phe Met 
    1715                 1720                 1725             


Leu Leu  Phe Phe Ile Phe Ala  Ala Leu Gly Val Glu  Leu Phe Gly 
    1730                 1735                 1740             


Asp Leu  Glu Cys Asp Glu Xaa  His Pro Cys Glu Gly  Leu Gly Arg 
    1745                 1750                 1755             


His Ala  Xaa Phe Arg Asn Phe  Gly Met Ala Phe Leu  Xaa Leu Phe 
    1760                 1765                 1770             


Arg Val  Ser Xaa Gly Asp Asn  Trp Asn Gly Ile Met  Lys Asp Xaa 
    1775                 1780                 1785             


Leu Arg  Asp Cys Asp Gln Glu  Ser Xaa Cys Tyr Asn  Xaa Val Ile 
    1790                 1795                 1800             


Ser Pro  Ile Tyr Phe Val Ser  Phe Val Leu Xaa Ala  Gln Phe Val 
    1805                 1810                 1815             


Leu Val  Asn Val Val Ile Ala  Val Leu Met Lys His  Leu Glu Glu 
    1820                 1825                 1830             


Ser Asn  Lys Glu Ala Lys Glu  Glu Ala Glu Leu Glu  Ala Glu Leu 
    1835                 1840                 1845             


Glu Leu  Glu Met Lys Xaa Leu  Ser Pro Gln Pro His  Ser Pro Leu 
    1850                 1855                 1860             


Gly Ser  Pro Phe Leu Trp Pro  Gly Val Glu Gly Pro  Asp Ser Pro 
    1865                 1870                 1875             


Asp Ser  Pro Lys Pro Gly Ala  Leu His Pro Ala Ala  His Ala Arg 
    1880                 1885                 1890             


Ser Ala  Ser His Phe Ser Leu  Glu His Pro Xaa Ile  Pro Leu Ala 
    1895                 1900                 1905             


Glu Met  Glu Ala Leu Ser Leu  Xaa Ser Glu Ile Val  Ser Glu Pro 
    1910                 1915                 1920             


Ser Cys  Ser Leu Ala Leu Xaa  Asp Asp Ser Leu Pro  Asp Asp Met 
    1925                 1930                 1935             


His Xaa  Leu Leu Leu Ser Ala  Leu Glu Ser Asn Met  Gln Pro His 
    1940                 1945                 1950             


Pro Xaa  Glu Leu Pro Gly Pro  Asp Leu Leu Xaa Val  Arg Lys Ser 
    1955                 1960                 1965             


Gly Val  Ser Arg Xaa His Ser  Leu Pro Asn Asp Ser  Tyr Met Cys 
    1970                 1975                 1980             


Arg His  Gly Ser Xaa Ala Glu  Gly Pro Leu Gly His  Arg Gly Trp 
    1985                 1990                 1995             


Gly Leu  Pro Lys Ala Gln Ser  Gly Ser Val Leu Ser  Val His Ser 
    2000                 2005                 2010             


Gln Pro  Ala Asp Xaa Ser Tyr  Ile Leu Gln Leu Pro  Lys Asp Ala 
    2015                 2020                 2025             


Pro His  Leu Leu Gln Pro His  Ser Ala Pro Xaa Trp  Gly Xaa Ile 
    2030                 2035                 2040             


Pro Lys  Leu Pro Pro Pro Gly  Arg Ser Pro Leu Ala  Gln Arg Pro 
    2045                 2050                 2055             


Leu Arg  Arg Gln Ala Ala Ile  Arg Xaa Asp Ser Leu  Asp Val Gln 
    2060                 2065                 2070             


Gly Leu  Gly Ser Arg Glu Asp  Leu Leu Ala Glu Val  Ser Gly Pro 
    2075                 2080                 2085             


Ser Pro  Pro Leu Ala Arg Ala  Tyr Ser Phe Trp Gly  Gln Ser Ser 
    2090                 2095                 2100             


Xaa Gln  Ala Gln Gln His Ser  Arg Ser His Ser Lys  Ile Ser Lys 
    2105                 2110                 2115             


His Met  Xaa Pro Pro Ala Pro  Cys Pro Gly Pro Glu  Pro Asn Trp 
    2120                 2125                 2130             


Gly Lys  Gly Pro Pro Glu Xaa  Arg Ser Ser Leu Glu  Leu Asp Xaa 
    2135                 2140                 2145             


Glu Leu  Ser Trp Ile Ser Gly  Asp Leu Leu Pro Pro  Gly Gly Gln 
    2150                 2155                 2160             


Glu Glu  Pro Pro Ser Pro Arg  Asp Leu Lys Lys Cys  Tyr Ser Val 
    2165                 2170                 2175             


Glu Ala  Gln Ser Cys Gln Arg  Arg Pro Xaa Ser Trp  Leu Asp Glu 
    2180                 2185                 2190             


Gln Arg  Arg His Ser Ile Ala  Val Ser Cys Leu Asp  Ser Gly Ser 
    2195                 2200                 2205             


Gln Pro  His Leu Gly Xaa Asp  Pro Ser Asn Leu Gly  Gly Gln Pro 
    2210                 2215                 2220             


Leu Gly  Gly Pro Gly Ser Arg  Pro Lys Lys Lys Leu  Ser Pro Pro 
    2225                 2230                 2235             


Ser Ile  Xaa Ile Asp Pro Pro  Glu Ser Gln Gly Pro  Arg Xaa Pro 
    2240                 2245                 2250             


Pro Ser  Pro Gly Ile Cys Leu  Arg Arg Arg Ala Pro  Ser Ser Asp 
    2255                 2260                 2265             


Ser Lys  Asp Pro Leu Ala Ser  Gly Pro Pro Asp Ser  Met Ala Ala 
    2270                 2275                 2280             


Ser Pro  Ser Pro Lys Lys Asp  Val Leu Ser Leu Ser  Gly Leu Ser 
    2285                 2290                 2295             


Ser Asp  Pro Ala Asp Leu Asp  Pro 
    2300                 2305     


<210> 4722
<211> 2314
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1591)..(1591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1600)..(1600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1673)..(1673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1688)..(1688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1717)..(1717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1755)..(1755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1766)..(1766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1776)..(1776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1782)..(1782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1793)..(1793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1802)..(1802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1806)..(1806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1819)..(1819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1859)..(1859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1909)..(1909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1916)..(1916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1963)..(1963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1972)..(1972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1981)..(1981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1996)..(1996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2026)..(2026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2047)..(2047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2050)..(2050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2075)..(2075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2112)..(2112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2129)..(2129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2148)..(2148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2156)..(2156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2196)..(2196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2222)..(2222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2249)..(2249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2260)..(2260)
<223> Selenocysteine

<400> 4722
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Pro  Ile Met Asn His Asn  Pro Trp Met Leu Leu  Tyr Phe Ile 
    1505                 1510                 1515             


Ser Phe  Leu Leu Ile Val Ala  Phe Phe Val Leu Asn  Met Phe Val 
    1520                 1525                 1530             


Gly Val  Val Val Glu Asn Phe  His Lys Cys Arg Gln  His Gln Glu 
    1535                 1540                 1545             


Glu Glu  Glu Ala Arg Arg Arg  Glu Glu Lys Arg Leu  Arg Arg Leu 
    1550                 1555                 1560             


Glu Lys  Lys Arg Arg Lys Ala  Gln Cys Lys Pro Tyr  Tyr Ser Asp 
    1565                 1570                 1575             


Tyr Ser  Arg Phe Arg Leu Leu  Val His His Leu Cys  Xaa Ser His 
    1580                 1585                 1590             


Tyr Leu  Asp Leu Phe Ile Xaa  Gly Val Ile Gly Leu  Asn Val Val 
    1595                 1600                 1605             


Xaa Met  Ala Met Glu His Tyr  Gln Gln Pro Gln Ile  Leu Asp Glu 
    1610                 1615                 1620             


Ala Leu  Lys Ile Cys Asn Tyr  Ile Phe Xaa Val Ile  Phe Val Leu 
    1625                 1630                 1635             


Glu Ser  Val Phe Lys Leu Val  Ala Phe Gly Phe Arg  Arg Phe Phe 
    1640                 1645                 1650             


Gln Asp  Arg Trp Asn Gln Leu  Asp Leu Ala Ile Val  Leu Leu Ser 
    1655                 1660                 1665             


Ile Met  Gly Ile Xaa Leu Glu  Glu Ile Glu Val Asn  Ala Ser Leu 
    1670                 1675                 1680             


Pro Ile  Asn Pro Xaa Ile Ile  Arg Ile Met Arg Val  Leu Arg Ile 
    1685                 1690                 1695             


Ala Arg  Val Leu Lys Leu Leu  Lys Met Ala Val Gly  Met Arg Ala 
    1700                 1705                 1710             


Leu Leu  Asp Xaa Val Met Gln  Ala Leu Pro Gln Val  Gly Asn Leu 
    1715                 1720                 1725             


Gly Leu  Leu Phe Met Leu Leu  Phe Phe Ile Phe Ala  Ala Leu Gly 
    1730                 1735                 1740             


Val Glu  Leu Phe Gly Asp Leu  Glu Cys Asp Glu Xaa  His Pro Cys 
    1745                 1750                 1755             


Glu Gly  Leu Gly Arg His Ala  Xaa Phe Arg Asn Phe  Gly Met Ala 
    1760                 1765                 1770             


Phe Leu  Xaa Leu Phe Arg Val  Ser Xaa Gly Asp Asn  Trp Asn Gly 
    1775                 1780                 1785             


Ile Met  Lys Asp Xaa Leu Arg  Asp Cys Asp Gln Glu  Ser Xaa Cys 
    1790                 1795                 1800             


Tyr Asn  Xaa Val Ile Ser Pro  Ile Tyr Phe Val Ser  Phe Val Leu 
    1805                 1810                 1815             


Xaa Ala  Gln Phe Val Leu Val  Asn Val Val Ile Ala  Val Leu Met 
    1820                 1825                 1830             


Lys His  Leu Glu Glu Ser Asn  Lys Glu Ala Lys Glu  Glu Ala Glu 
    1835                 1840                 1845             


Leu Glu  Ala Glu Leu Glu Leu  Glu Met Lys Xaa Leu  Ser Pro Gln 
    1850                 1855                 1860             


Pro His  Ser Pro Leu Gly Ser  Pro Phe Leu Trp Pro  Gly Val Glu 
    1865                 1870                 1875             


Gly Pro  Asp Ser Pro Asp Ser  Pro Lys Pro Gly Ala  Leu His Pro 
    1880                 1885                 1890             


Ala Ala  His Ala Arg Ser Ala  Ser His Phe Ser Leu  Glu His Pro 
    1895                 1900                 1905             


Xaa Asp  Arg Gln Leu Phe Asp  Xaa Ile Ser Leu Leu  Ile Gln Gly 
    1910                 1915                 1920             


Ser Leu  Glu Trp Glu Leu Lys  Leu Met Asp Glu Leu  Ala Gly Pro 
    1925                 1930                 1935             


Gly Gly  Gln Pro Ser Ala Phe  Pro Ser Ala Pro Ser  Leu Gly Gly 
    1940                 1945                 1950             


Ser Asp  Pro Gln Met Gln Pro  His Pro Xaa Glu Leu  Pro Gly Pro 
    1955                 1960                 1965             


Asp Leu  Leu Xaa Val Arg Lys  Ser Gly Val Ser Arg  Xaa His Ser 
    1970                 1975                 1980             


Leu Pro  Asn Asp Ser Tyr Met  Cys Arg His Gly Ser  Xaa Ala Glu 
    1985                 1990                 1995             


Gly Pro  Leu Gly His Arg Gly  Trp Gly Leu Pro Lys  Ala Gln Ser 
    2000                 2005                 2010             


Gly Ser  Val Leu Ser Val His  Ser Gln Pro Ala Asp  Xaa Ser Tyr 
    2015                 2020                 2025             


Ile Leu  Gln Leu Pro Lys Asp  Ala Pro His Leu Leu  Gln Pro His 
    2030                 2035                 2040             


Ser Ala  Pro Xaa Trp Gly Xaa  Ile Pro Lys Leu Pro  Pro Pro Gly 
    2045                 2050                 2055             


Arg Ser  Pro Leu Ala Gln Arg  Pro Leu Arg Arg Gln  Ala Ala Ile 
    2060                 2065                 2070             


Arg Xaa  Asp Ser Leu Asp Val  Gln Gly Leu Gly Ser  Arg Glu Asp 
    2075                 2080                 2085             


Leu Leu  Ala Glu Val Ser Gly  Pro Ser Pro Pro Leu  Ala Arg Ala 
    2090                 2095                 2100             


Tyr Ser  Phe Trp Gly Gln Ser  Ser Xaa Gln Ala Gln  Gln His Ser 
    2105                 2110                 2115             


Arg Ser  His Ser Lys Ile Ser  Lys His Met Xaa Pro  Pro Ala Pro 
    2120                 2125                 2130             


Cys Pro  Gly Pro Glu Pro Asn  Trp Gly Lys Gly Pro  Pro Glu Xaa 
    2135                 2140                 2145             


Arg Ser  Ser Leu Glu Leu Asp  Xaa Glu Leu Ser Trp  Ile Ser Gly 
    2150                 2155                 2160             


Asp Leu  Leu Pro Pro Gly Gly  Gln Glu Glu Pro Pro  Ser Pro Arg 
    2165                 2170                 2175             


Asp Leu  Lys Lys Cys Tyr Ser  Val Glu Ala Gln Ser  Cys Gln Arg 
    2180                 2185                 2190             


Arg Pro  Xaa Ser Trp Leu Asp  Glu Gln Arg Arg His  Ser Ile Ala 
    2195                 2200                 2205             


Val Ser  Cys Leu Asp Ser Gly  Ser Gln Pro His Leu  Gly Xaa Asp 
    2210                 2215                 2220             


Pro Ser  Asn Leu Gly Gly Gln  Pro Leu Gly Gly Pro  Gly Ser Arg 
    2225                 2230                 2235             


Pro Lys  Lys Lys Leu Ser Pro  Pro Ser Ile Xaa Ile  Asp Pro Pro 
    2240                 2245                 2250             


Glu Ser  Gln Gly Pro Arg Xaa  Pro Pro Ser Pro Gly  Ile Cys Leu 
    2255                 2260                 2265             


Arg Arg  Arg Ala Pro Ser Ser  Asp Ser Lys Asp Pro  Leu Ala Ser 
    2270                 2275                 2280             


Gly Pro  Pro Asp Ser Met Ala  Ala Ser Pro Ser Pro  Lys Lys Asp 
    2285                 2290                 2295             


Val Leu  Ser Leu Ser Gly Leu  Ser Ser Asp Pro Ala  Asp Leu Asp 
    2300                 2305                 2310             


Pro 
    


<210> 4723
<211> 2321
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1598)..(1598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1616)..(1616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1680)..(1680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1695)..(1695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1724)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1762)..(1762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1783)..(1783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1789)..(1789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1800)..(1800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1809)..(1809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1813)..(1813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1826)..(1826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1866)..(1866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1916)..(1916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1923)..(1923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1970)..(1970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1979)..(1979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1988)..(1988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2003)..(2003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2033)..(2033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2054)..(2054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2057)..(2057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2082)..(2082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2119)..(2119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2136)..(2136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2155)..(2155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2163)..(2163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2203)..(2203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2229)..(2229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2256)..(2256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2267)..(2267)
<223> Selenocysteine

<400> 4723
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Pro  Ile Met Asn His Asn  Pro Trp Met Leu Leu  Tyr Phe Ile 
    1505                 1510                 1515             


Ser Phe  Leu Leu Ile Val Ala  Phe Phe Val Leu Asn  Met Phe Val 
    1520                 1525                 1530             


Gly Val  Val Val Glu Asn Phe  His Lys Cys Arg Gln  His Gln Glu 
    1535                 1540                 1545             


Glu Glu  Glu Ala Arg Arg Arg  Glu Glu Lys Arg Leu  Arg Arg Leu 
    1550                 1555                 1560             


Glu Lys  Lys Arg Arg Ser Lys  Glu Lys Gln Met Ala  Glu Ala Gln 
    1565                 1570                 1575             


Cys Lys  Pro Tyr Tyr Ser Asp  Tyr Ser Arg Phe Arg  Leu Leu Val 
    1580                 1585                 1590             


His His  Leu Cys Xaa Ser His  Tyr Leu Asp Leu Phe  Ile Xaa Gly 
    1595                 1600                 1605             


Val Ile  Gly Leu Asn Val Val  Xaa Met Ala Met Glu  His Tyr Gln 
    1610                 1615                 1620             


Gln Pro  Gln Ile Leu Asp Glu  Ala Leu Lys Ile Cys  Asn Tyr Ile 
    1625                 1630                 1635             


Phe Xaa  Val Ile Phe Val Leu  Glu Ser Val Phe Lys  Leu Val Ala 
    1640                 1645                 1650             


Phe Gly  Phe Arg Arg Phe Phe  Gln Asp Arg Trp Asn  Gln Leu Asp 
    1655                 1660                 1665             


Leu Ala  Ile Val Leu Leu Ser  Ile Met Gly Ile Xaa  Leu Glu Glu 
    1670                 1675                 1680             


Ile Glu  Val Asn Ala Ser Leu  Pro Ile Asn Pro Xaa  Ile Ile Arg 
    1685                 1690                 1695             


Ile Met  Arg Val Leu Arg Ile  Ala Arg Val Leu Lys  Leu Leu Lys 
    1700                 1705                 1710             


Met Ala  Val Gly Met Arg Ala  Leu Leu Asp Xaa Val  Met Gln Ala 
    1715                 1720                 1725             


Leu Pro  Gln Val Gly Asn Leu  Gly Leu Leu Phe Met  Leu Leu Phe 
    1730                 1735                 1740             


Phe Ile  Phe Ala Ala Leu Gly  Val Glu Leu Phe Gly  Asp Leu Glu 
    1745                 1750                 1755             


Cys Asp  Glu Xaa His Pro Cys  Glu Gly Leu Gly Arg  His Ala Xaa 
    1760                 1765                 1770             


Phe Arg  Asn Phe Gly Met Ala  Phe Leu Xaa Leu Phe  Arg Val Ser 
    1775                 1780                 1785             


Xaa Gly  Asp Asn Trp Asn Gly  Ile Met Lys Asp Xaa  Leu Arg Asp 
    1790                 1795                 1800             


Cys Asp  Gln Glu Ser Xaa Cys  Tyr Asn Xaa Val Ile  Ser Pro Ile 
    1805                 1810                 1815             


Tyr Phe  Val Ser Phe Val Leu  Xaa Ala Gln Phe Val  Leu Val Asn 
    1820                 1825                 1830             


Val Val  Ile Ala Val Leu Met  Lys His Leu Glu Glu  Ser Asn Lys 
    1835                 1840                 1845             


Glu Ala  Lys Glu Glu Ala Glu  Leu Glu Ala Glu Leu  Glu Leu Glu 
    1850                 1855                 1860             


Met Lys  Xaa Leu Ser Pro Gln  Pro His Ser Pro Leu  Gly Ser Pro 
    1865                 1870                 1875             


Phe Leu  Trp Pro Gly Val Glu  Gly Pro Asp Ser Pro  Asp Ser Pro 
    1880                 1885                 1890             


Lys Pro  Gly Ala Leu His Pro  Ala Ala His Ala Arg  Ser Ala Ser 
    1895                 1900                 1905             


His Phe  Ser Leu Glu His Pro  Xaa Asp Arg Gln Leu  Phe Asp Xaa 
    1910                 1915                 1920             


Ile Ser  Leu Leu Ile Gln Gly  Ser Leu Glu Trp Glu  Leu Lys Leu 
    1925                 1930                 1935             


Met Asp  Glu Leu Ala Gly Pro  Gly Gly Gln Pro Ser  Ala Phe Pro 
    1940                 1945                 1950             


Ser Ala  Pro Ser Leu Gly Gly  Ser Asp Pro Gln Met  Gln Pro His 
    1955                 1960                 1965             


Pro Xaa  Glu Leu Pro Gly Pro  Asp Leu Leu Xaa Val  Arg Lys Ser 
    1970                 1975                 1980             


Gly Val  Ser Arg Xaa His Ser  Leu Pro Asn Asp Ser  Tyr Met Cys 
    1985                 1990                 1995             


Arg His  Gly Ser Xaa Ala Glu  Gly Pro Leu Gly His  Arg Gly Trp 
    2000                 2005                 2010             


Gly Leu  Pro Lys Ala Gln Ser  Gly Ser Val Leu Ser  Val His Ser 
    2015                 2020                 2025             


Gln Pro  Ala Asp Xaa Ser Tyr  Ile Leu Gln Leu Pro  Lys Asp Ala 
    2030                 2035                 2040             


Pro His  Leu Leu Gln Pro His  Ser Ala Pro Xaa Trp  Gly Xaa Ile 
    2045                 2050                 2055             


Pro Lys  Leu Pro Pro Pro Gly  Arg Ser Pro Leu Ala  Gln Arg Pro 
    2060                 2065                 2070             


Leu Arg  Arg Gln Ala Ala Ile  Arg Xaa Asp Ser Leu  Asp Val Gln 
    2075                 2080                 2085             


Gly Leu  Gly Ser Arg Glu Asp  Leu Leu Ala Glu Val  Ser Gly Pro 
    2090                 2095                 2100             


Ser Pro  Pro Leu Ala Arg Ala  Tyr Ser Phe Trp Gly  Gln Ser Ser 
    2105                 2110                 2115             


Xaa Gln  Ala Gln Gln His Ser  Arg Ser His Ser Lys  Ile Ser Lys 
    2120                 2125                 2130             


His Met  Xaa Pro Pro Ala Pro  Cys Pro Gly Pro Glu  Pro Asn Trp 
    2135                 2140                 2145             


Gly Lys  Gly Pro Pro Glu Xaa  Arg Ser Ser Leu Glu  Leu Asp Xaa 
    2150                 2155                 2160             


Glu Leu  Ser Trp Ile Ser Gly  Asp Leu Leu Pro Pro  Gly Gly Gln 
    2165                 2170                 2175             


Glu Glu  Pro Pro Ser Pro Arg  Asp Leu Lys Lys Cys  Tyr Ser Val 
    2180                 2185                 2190             


Glu Ala  Gln Ser Cys Gln Arg  Arg Pro Xaa Ser Trp  Leu Asp Glu 
    2195                 2200                 2205             


Gln Arg  Arg His Ser Ile Ala  Val Ser Cys Leu Asp  Ser Gly Ser 
    2210                 2215                 2220             


Gln Pro  His Leu Gly Xaa Asp  Pro Ser Asn Leu Gly  Gly Gln Pro 
    2225                 2230                 2235             


Leu Gly  Gly Pro Gly Ser Arg  Pro Lys Lys Lys Leu  Ser Pro Pro 
    2240                 2245                 2250             


Ser Ile  Xaa Ile Asp Pro Pro  Glu Ser Gln Gly Pro  Arg Xaa Pro 
    2255                 2260                 2265             


Pro Ser  Pro Gly Ile Cys Leu  Arg Arg Arg Ala Pro  Ser Ser Asp 
    2270                 2275                 2280             


Ser Lys  Asp Pro Leu Ala Ser  Gly Pro Pro Asp Ser  Met Ala Ala 
    2285                 2290                 2295             


Ser Pro  Ser Pro Lys Lys Asp  Val Leu Ser Leu Ser  Gly Leu Ser 
    2300                 2305                 2310             


Ser Asp  Pro Ala Asp Leu Asp  Pro 
    2315                 2320     


<210> 4724
<211> 2332
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1618)..(1618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1627)..(1627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1651)..(1651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1691)..(1691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1706)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1735)..(1735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1784)..(1784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1794)..(1794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1800)..(1800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1811)..(1811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1820)..(1820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1824)..(1824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1837)..(1837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1877)..(1877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1927)..(1927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1934)..(1934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1981)..(1981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1990)..(1990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1999)..(1999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2014)..(2014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2044)..(2044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2065)..(2065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2068)..(2068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2093)..(2093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2130)..(2130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2147)..(2147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2166)..(2166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2174)..(2174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2214)..(2214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2240)..(2240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2267)..(2267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2278)..(2278)
<223> Selenocysteine

<400> 4724
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Pro  Ile Met Asn His Asn  Pro Trp Met Leu Leu  Tyr Phe Ile 
    1505                 1510                 1515             


Ser Phe  Leu Leu Ile Val Ala  Phe Phe Val Leu Asn  Met Phe Val 
    1520                 1525                 1530             


Gly Val  Val Val Glu Asn Phe  His Lys Cys Arg Gln  His Gln Glu 
    1535                 1540                 1545             


Glu Glu  Glu Ala Arg Arg Arg  Glu Glu Lys Arg Leu  Arg Arg Leu 
    1550                 1555                 1560             


Glu Lys  Lys Arg Arg Asn Leu  Met Leu Asp Asp Val  Ile Ala Ser 
    1565                 1570                 1575             


Gly Ser  Ser Ala Ser Ala Ala  Ser Glu Ala Gln Cys  Lys Pro Tyr 
    1580                 1585                 1590             


Tyr Ser  Asp Tyr Ser Arg Phe  Arg Leu Leu Val His  His Leu Cys 
    1595                 1600                 1605             


Xaa Ser  His Tyr Leu Asp Leu  Phe Ile Xaa Gly Val  Ile Gly Leu 
    1610                 1615                 1620             


Asn Val  Val Xaa Met Ala Met  Glu His Tyr Gln Gln  Pro Gln Ile 
    1625                 1630                 1635             


Leu Asp  Glu Ala Leu Lys Ile  Cys Asn Tyr Ile Phe  Xaa Val Ile 
    1640                 1645                 1650             


Phe Val  Leu Glu Ser Val Phe  Lys Leu Val Ala Phe  Gly Phe Arg 
    1655                 1660                 1665             


Arg Phe  Phe Gln Asp Arg Trp  Asn Gln Leu Asp Leu  Ala Ile Val 
    1670                 1675                 1680             


Leu Leu  Ser Ile Met Gly Ile  Xaa Leu Glu Glu Ile  Glu Val Asn 
    1685                 1690                 1695             


Ala Ser  Leu Pro Ile Asn Pro  Xaa Ile Ile Arg Ile  Met Arg Val 
    1700                 1705                 1710             


Leu Arg  Ile Ala Arg Val Leu  Lys Leu Leu Lys Met  Ala Val Gly 
    1715                 1720                 1725             


Met Arg  Ala Leu Leu Asp Xaa  Val Met Gln Ala Leu  Pro Gln Val 
    1730                 1735                 1740             


Gly Asn  Leu Gly Leu Leu Phe  Met Leu Leu Phe Phe  Ile Phe Ala 
    1745                 1750                 1755             


Ala Leu  Gly Val Glu Leu Phe  Gly Asp Leu Glu Cys  Asp Glu Xaa 
    1760                 1765                 1770             


His Pro  Cys Glu Gly Leu Gly  Arg His Ala Xaa Phe  Arg Asn Phe 
    1775                 1780                 1785             


Gly Met  Ala Phe Leu Xaa Leu  Phe Arg Val Ser Xaa  Gly Asp Asn 
    1790                 1795                 1800             


Trp Asn  Gly Ile Met Lys Asp  Xaa Leu Arg Asp Cys  Asp Gln Glu 
    1805                 1810                 1815             


Ser Xaa  Cys Tyr Asn Xaa Val  Ile Ser Pro Ile Tyr  Phe Val Ser 
    1820                 1825                 1830             


Phe Val  Leu Xaa Ala Gln Phe  Val Leu Val Asn Val  Val Ile Ala 
    1835                 1840                 1845             


Val Leu  Met Lys His Leu Glu  Glu Ser Asn Lys Glu  Ala Lys Glu 
    1850                 1855                 1860             


Glu Ala  Glu Leu Glu Ala Glu  Leu Glu Leu Glu Met  Lys Xaa Leu 
    1865                 1870                 1875             


Ser Pro  Gln Pro His Ser Pro  Leu Gly Ser Pro Phe  Leu Trp Pro 
    1880                 1885                 1890             


Gly Val  Glu Gly Pro Asp Ser  Pro Asp Ser Pro Lys  Pro Gly Ala 
    1895                 1900                 1905             


Leu His  Pro Ala Ala His Ala  Arg Ser Ala Ser His  Phe Ser Leu 
    1910                 1915                 1920             


Glu His  Pro Xaa Asp Arg Gln  Leu Phe Asp Xaa Ile  Ser Leu Leu 
    1925                 1930                 1935             


Ile Gln  Gly Ser Leu Glu Trp  Glu Leu Lys Leu Met  Asp Glu Leu 
    1940                 1945                 1950             


Ala Gly  Pro Gly Gly Gln Pro  Ser Ala Phe Pro Ser  Ala Pro Ser 
    1955                 1960                 1965             


Leu Gly  Gly Ser Asp Pro Gln  Met Gln Pro His Pro  Xaa Glu Leu 
    1970                 1975                 1980             


Pro Gly  Pro Asp Leu Leu Xaa  Val Arg Lys Ser Gly  Val Ser Arg 
    1985                 1990                 1995             


Xaa His  Ser Leu Pro Asn Asp  Ser Tyr Met Cys Arg  His Gly Ser 
    2000                 2005                 2010             


Xaa Ala  Glu Gly Pro Leu Gly  His Arg Gly Trp Gly  Leu Pro Lys 
    2015                 2020                 2025             


Ala Gln  Ser Gly Ser Val Leu  Ser Val His Ser Gln  Pro Ala Asp 
    2030                 2035                 2040             


Xaa Ser  Tyr Ile Leu Gln Leu  Pro Lys Asp Ala Pro  His Leu Leu 
    2045                 2050                 2055             


Gln Pro  His Ser Ala Pro Xaa  Trp Gly Xaa Ile Pro  Lys Leu Pro 
    2060                 2065                 2070             


Pro Pro  Gly Arg Ser Pro Leu  Ala Gln Arg Pro Leu  Arg Arg Gln 
    2075                 2080                 2085             


Ala Ala  Ile Arg Xaa Asp Ser  Leu Asp Val Gln Gly  Leu Gly Ser 
    2090                 2095                 2100             


Arg Glu  Asp Leu Leu Ala Glu  Val Ser Gly Pro Ser  Pro Pro Leu 
    2105                 2110                 2115             


Ala Arg  Ala Tyr Ser Phe Trp  Gly Gln Ser Ser Xaa  Gln Ala Gln 
    2120                 2125                 2130             


Gln His  Ser Arg Ser His Ser  Lys Ile Ser Lys His  Met Xaa Pro 
    2135                 2140                 2145             


Pro Ala  Pro Cys Pro Gly Pro  Glu Pro Asn Trp Gly  Lys Gly Pro 
    2150                 2155                 2160             


Pro Glu  Xaa Arg Ser Ser Leu  Glu Leu Asp Xaa Glu  Leu Ser Trp 
    2165                 2170                 2175             


Ile Ser  Gly Asp Leu Leu Pro  Pro Gly Gly Gln Glu  Glu Pro Pro 
    2180                 2185                 2190             


Ser Pro  Arg Asp Leu Lys Lys  Cys Tyr Ser Val Glu  Ala Gln Ser 
    2195                 2200                 2205             


Cys Gln  Arg Arg Pro Xaa Ser  Trp Leu Asp Glu Gln  Arg Arg His 
    2210                 2215                 2220             


Ser Ile  Ala Val Ser Cys Leu  Asp Ser Gly Ser Gln  Pro His Leu 
    2225                 2230                 2235             


Gly Xaa  Asp Pro Ser Asn Leu  Gly Gly Gln Pro Leu  Gly Gly Pro 
    2240                 2245                 2250             


Gly Ser  Arg Pro Lys Lys Lys  Leu Ser Pro Pro Ser  Ile Xaa Ile 
    2255                 2260                 2265             


Asp Pro  Pro Glu Ser Gln Gly  Pro Arg Xaa Pro Pro  Ser Pro Gly 
    2270                 2275                 2280             


Ile Cys  Leu Arg Arg Arg Ala  Pro Ser Ser Asp Ser  Lys Asp Pro 
    2285                 2290                 2295             


Leu Ala  Ser Gly Pro Pro Asp  Ser Met Ala Ala Ser  Pro Ser Pro 
    2300                 2305                 2310             


Lys Lys  Asp Val Leu Ser Leu  Ser Gly Leu Ser Ser  Asp Pro Ala 
    2315                 2320                 2325             


Asp Leu  Asp Pro 
    2330         


<210> 4725
<211> 2343
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1575)..(1575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1584)..(1584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1593)..(1593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1617)..(1617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1672)..(1672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1701)..(1701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1739)..(1739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1750)..(1750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1766)..(1766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1777)..(1777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1786)..(1786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1803)..(1803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1843)..(1843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1893)..(1893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1900)..(1900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1953)..(1953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1967)..(1967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1977)..(1977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1992)..(1992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2001)..(2001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2010)..(2010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2025)..(2025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2055)..(2055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2076)..(2076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2079)..(2079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2104)..(2104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2141)..(2141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2158)..(2158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2177)..(2177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2185)..(2185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2225)..(2225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2251)..(2251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2278)..(2278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2289)..(2289)
<223> Selenocysteine

<400> 4725
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Gly Asp Ala Asn Lys Ser 
                965                 970                 975     


Glu Ser Glu Pro Asp Phe Phe Ser Pro Ser Leu Asp Gly Asp Gly Asp 
            980                 985                 990         


Arg Lys Lys Cys Leu Ala Leu Val  Ser Leu Gly Glu His  Pro Glu Leu 
        995                 1000                 1005             


Arg Lys  Ser Leu Leu Pro Pro  Leu Ile Ile His Xaa  Ala Ala Xaa 
    1010                 1015                 1020             


Pro Met  Ser Leu Pro Lys Ser  Xaa Ser Xaa Gly Leu  Gly Glu Ala 
    1025                 1030                 1035             


Leu Gly  Pro Ala Ser Arg Arg  Xaa Ser Ser Ser Gly  Ser Ala Glu 
    1040                 1045                 1050             


Pro Gly  Ala Ala His Glu Met  Lys Ser Pro Pro Ser  Ala Arg Ser 
    1055                 1060                 1065             


Ser Pro  His Ser Pro Trp Ser  Ala Ala Ser Ser Trp  Xaa Ser Arg 
    1070                 1075                 1080             


Arg Ser  Ser Arg Asn Ser Leu  Gly Arg Ala Pro Ser  Leu Lys Arg 
    1085                 1090                 1095             


Arg Ser  Pro Ser Gly Glu Arg  Arg Ser Leu Leu Ser  Gly Glu Gly 
    1100                 1105                 1110             


Gln Glu  Ser Gln Asp Glu Glu  Glu Ser Ser Glu Glu  Glu Arg Ala 
    1115                 1120                 1125             


Ser Pro  Ala Gly Ser Asp His  Arg His Arg Gly Ser  Leu Glu Arg 
    1130                 1135                 1140             


Glu Ala  Lys Ser Ser Phe Asp  Leu Pro Asp Xaa Leu  Gln Val Pro 
    1145                 1150                 1155             


Gly Leu  His Arg Xaa Ala Ser  Gly Arg Gly Ser Ala  Ser Glu His 
    1160                 1165                 1170             


Gln Asp  Cys Asn Gly Lys Ser  Ala Ser Gly Arg Leu  Ala Arg Ala 
    1175                 1180                 1185             


Leu Arg  Pro Asp Asp Pro Pro  Leu Asp Gly Asp Asp  Ala Asp Asp 
    1190                 1195                 1200             


Glu Gly  Asn Leu Ser Lys Gly  Glu Arg Val Arg Ala  Trp Ile Arg 
    1205                 1210                 1215             


Ala Arg  Leu Pro Ala Cys Cys  Leu Glu Arg Asp Ser  Trp Ser Ala 
    1220                 1225                 1230             


Tyr Ile  Phe Pro Pro Gln Ser  Arg Phe Arg Leu Leu  Cys His Arg 
    1235                 1240                 1245             


Ile Ile  Xaa His Lys Met Phe  Asp His Val Val Leu  Val Ile Ile 
    1250                 1255                 1260             


Phe Leu  Asn Cys Ile Xaa Ile  Ala Met Glu Arg Pro  Lys Ile Asp 
    1265                 1270                 1275             


Pro His  Ser Ala Glu Arg Ile  Phe Leu Xaa Leu Ser  Asn Tyr Ile 
    1280                 1285                 1290             


Phe Xaa  Ala Val Phe Leu Ala  Glu Met Xaa Val Lys  Val Val Ala 
    1295                 1300                 1305             


Leu Gly  Trp Cys Phe Gly Glu  Gln Ala Tyr Leu Arg  Ser Ser Trp 
    1310                 1315                 1320             


Asn Val  Leu Asp Gly Leu Leu  Val Leu Ile Ser Val  Ile Asp Ile 
    1325                 1330                 1335             


Leu Val  Ser Met Val Ser Asp  Ser Gly Xaa Lys Ile  Leu Gly Met 
    1340                 1345                 1350             


Leu Arg  Val Leu Arg Leu Leu  Arg Xaa Leu Arg Pro  Leu Arg Val 
    1355                 1360                 1365             


Ile Ser  Arg Ala Gln Gly Leu  Lys Leu Val Val Glu  Xaa Leu Met 
    1370                 1375                 1380             


Ser Ser  Leu Lys Pro Ile Gly  Asn Ile Val Val Ile  Cys Cys Ala 
    1385                 1390                 1395             


Phe Phe  Ile Ile Phe Gly Ile  Leu Gly Val Gln Leu  Phe Lys Gly 
    1400                 1405                 1410             


Lys Phe  Phe Val Cys Gln Gly  Glu Asp Xaa Arg Asn  Ile Xaa Asn 
    1415                 1420                 1425             


Lys Ser  Asp Cys Ala Glu Ala  Ser Tyr Arg Trp Val  Arg His Lys 
    1430                 1435                 1440             


Tyr Asn  Phe Asp Asn Leu Gly  Gln Ala Leu Met Ser  Leu Phe Val 
    1445                 1450                 1455             


Leu Ala  Ser Lys Asp Gly Trp  Val Asp Ile Met Tyr  Asp Gly Leu 
    1460                 1465                 1470             


Asp Ala  Val Gly Val Asp Gln  Gln Pro Ile Met Asn  His Asn Pro 
    1475                 1480                 1485             


Trp Met  Leu Leu Tyr Phe Ile  Ser Phe Leu Leu Ile  Val Ala Phe 
    1490                 1495                 1500             


Phe Val  Leu Asn Met Phe Val  Gly Val Val Val Glu  Asn Phe His 
    1505                 1510                 1515             


Lys Cys  Arg Gln His Gln Glu  Glu Glu Glu Ala Arg  Arg Arg Glu 
    1520                 1525                 1530             


Glu Lys  Arg Leu Arg Arg Leu  Glu Lys Lys Arg Arg  Ser Lys Glu 
    1535                 1540                 1545             


Lys Gln  Met Ala Glu Ala Gln  Cys Lys Pro Tyr Tyr  Ser Asp Tyr 
    1550                 1555                 1560             


Ser Arg  Phe Arg Leu Leu Val  His His Leu Cys Xaa  Ser His Tyr 
    1565                 1570                 1575             


Leu Asp  Leu Phe Ile Xaa Gly  Val Ile Gly Leu Asn  Val Val Xaa 
    1580                 1585                 1590             


Met Ala  Met Glu His Tyr Gln  Gln Pro Gln Ile Leu  Asp Glu Ala 
    1595                 1600                 1605             


Leu Lys  Ile Cys Asn Tyr Ile  Phe Xaa Val Ile Phe  Val Leu Glu 
    1610                 1615                 1620             


Ser Val  Phe Lys Leu Val Ala  Phe Gly Phe Arg Arg  Phe Phe Gln 
    1625                 1630                 1635             


Asp Arg  Trp Asn Gln Leu Asp  Leu Ala Ile Val Leu  Leu Ser Ile 
    1640                 1645                 1650             


Met Gly  Ile Xaa Leu Glu Glu  Ile Glu Val Asn Ala  Ser Leu Pro 
    1655                 1660                 1665             


Ile Asn  Pro Xaa Ile Ile Arg  Ile Met Arg Val Leu  Arg Ile Ala 
    1670                 1675                 1680             


Arg Val  Leu Lys Leu Leu Lys  Met Ala Val Gly Met  Arg Ala Leu 
    1685                 1690                 1695             


Leu Asp  Xaa Val Met Gln Ala  Leu Pro Gln Val Gly  Asn Leu Gly 
    1700                 1705                 1710             


Leu Leu  Phe Met Leu Leu Phe  Phe Ile Phe Ala Ala  Leu Gly Val 
    1715                 1720                 1725             


Glu Leu  Phe Gly Asp Leu Glu  Cys Asp Glu Xaa His  Pro Cys Glu 
    1730                 1735                 1740             


Gly Leu  Gly Arg His Ala Xaa  Phe Arg Asn Phe Gly  Met Ala Phe 
    1745                 1750                 1755             


Leu Xaa  Leu Phe Arg Val Ser  Xaa Gly Asp Asn Trp  Asn Gly Ile 
    1760                 1765                 1770             


Met Lys  Asp Xaa Leu Arg Asp  Cys Asp Gln Glu Ser  Xaa Cys Tyr 
    1775                 1780                 1785             


Asn Xaa  Val Ile Ser Pro Ile  Tyr Phe Val Ser Phe  Val Leu Xaa 
    1790                 1795                 1800             


Ala Gln  Phe Val Leu Val Asn  Val Val Ile Ala Val  Leu Met Lys 
    1805                 1810                 1815             


His Leu  Glu Glu Ser Asn Lys  Glu Ala Lys Glu Glu  Ala Glu Leu 
    1820                 1825                 1830             


Glu Ala  Glu Leu Glu Leu Glu  Met Lys Xaa Leu Ser  Pro Gln Pro 
    1835                 1840                 1845             


His Ser  Pro Leu Gly Ser Pro  Phe Leu Trp Pro Gly  Val Glu Gly 
    1850                 1855                 1860             


Pro Asp  Ser Pro Asp Ser Pro  Lys Pro Gly Ala Leu  His Pro Ala 
    1865                 1870                 1875             


Ala His  Ala Arg Ser Ala Ser  His Phe Ser Leu Glu  His Pro Xaa 
    1880                 1885                 1890             


Asp Arg  Gln Leu Phe Asp Xaa  Ile Ser Leu Leu Ile  Gln Gly Ser 
    1895                 1900                 1905             


Leu Glu  Trp Glu Leu Lys Leu  Met Asp Glu Leu Ala  Gly Pro Gly 
    1910                 1915                 1920             


Gly Gln  Pro Ser Ala Phe Pro  Ser Ala Pro Ser Leu  Gly Gly Ser 
    1925                 1930                 1935             


Asp Pro  Gln Ile Pro Leu Ala  Glu Met Glu Ala Leu  Ser Leu Xaa 
    1940                 1945                 1950             


Ser Glu  Ile Val Ser Glu Pro  Ser Cys Ser Leu Ala  Leu Xaa Asp 
    1955                 1960                 1965             


Asp Ser  Leu Pro Asp Asp Met  His Xaa Leu Leu Leu  Ser Ala Leu 
    1970                 1975                 1980             


Glu Ser  Asn Met Gln Pro His  Pro Xaa Glu Leu Pro  Gly Pro Asp 
    1985                 1990                 1995             


Leu Leu  Xaa Val Arg Lys Ser  Gly Val Ser Arg Xaa  His Ser Leu 
    2000                 2005                 2010             


Pro Asn  Asp Ser Tyr Met Cys  Arg His Gly Ser Xaa  Ala Glu Gly 
    2015                 2020                 2025             


Pro Leu  Gly His Arg Gly Trp  Gly Leu Pro Lys Ala  Gln Ser Gly 
    2030                 2035                 2040             


Ser Val  Leu Ser Val His Ser  Gln Pro Ala Asp Xaa  Ser Tyr Ile 
    2045                 2050                 2055             


Leu Gln  Leu Pro Lys Asp Ala  Pro His Leu Leu Gln  Pro His Ser 
    2060                 2065                 2070             


Ala Pro  Xaa Trp Gly Xaa Ile  Pro Lys Leu Pro Pro  Pro Gly Arg 
    2075                 2080                 2085             


Ser Pro  Leu Ala Gln Arg Pro  Leu Arg Arg Gln Ala  Ala Ile Arg 
    2090                 2095                 2100             


Xaa Asp  Ser Leu Asp Val Gln  Gly Leu Gly Ser Arg  Glu Asp Leu 
    2105                 2110                 2115             


Leu Ala  Glu Val Ser Gly Pro  Ser Pro Pro Leu Ala  Arg Ala Tyr 
    2120                 2125                 2130             


Ser Phe  Trp Gly Gln Ser Ser  Xaa Gln Ala Gln Gln  His Ser Arg 
    2135                 2140                 2145             


Ser His  Ser Lys Ile Ser Lys  His Met Xaa Pro Pro  Ala Pro Cys 
    2150                 2155                 2160             


Pro Gly  Pro Glu Pro Asn Trp  Gly Lys Gly Pro Pro  Glu Xaa Arg 
    2165                 2170                 2175             


Ser Ser  Leu Glu Leu Asp Xaa  Glu Leu Ser Trp Ile  Ser Gly Asp 
    2180                 2185                 2190             


Leu Leu  Pro Pro Gly Gly Gln  Glu Glu Pro Pro Ser  Pro Arg Asp 
    2195                 2200                 2205             


Leu Lys  Lys Cys Tyr Ser Val  Glu Ala Gln Ser Cys  Gln Arg Arg 
    2210                 2215                 2220             


Pro Xaa  Ser Trp Leu Asp Glu  Gln Arg Arg His Ser  Ile Ala Val 
    2225                 2230                 2235             


Ser Cys  Leu Asp Ser Gly Ser  Gln Pro His Leu Gly  Xaa Asp Pro 
    2240                 2245                 2250             


Ser Asn  Leu Gly Gly Gln Pro  Leu Gly Gly Pro Gly  Ser Arg Pro 
    2255                 2260                 2265             


Lys Lys  Lys Leu Ser Pro Pro  Ser Ile Xaa Ile Asp  Pro Pro Glu 
    2270                 2275                 2280             


Ser Gln  Gly Pro Arg Xaa Pro  Pro Ser Pro Gly Ile  Cys Leu Arg 
    2285                 2290                 2295             


Arg Arg  Ala Pro Ser Ser Asp  Ser Lys Asp Pro Leu  Ala Ser Gly 
    2300                 2305                 2310             


Pro Pro  Asp Ser Met Ala Ala  Ser Pro Ser Pro Lys  Lys Asp Val 
    2315                 2320                 2325             


Leu Ser  Leu Ser Gly Leu Ser  Ser Asp Pro Ala Asp  Leu Asp Pro 
    2330                 2335                 2340             


<210> 4726
<211> 2366
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1598)..(1598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1616)..(1616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1640)..(1640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1680)..(1680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1695)..(1695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1724)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1762)..(1762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1783)..(1783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1789)..(1789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1800)..(1800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1809)..(1809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1813)..(1813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1826)..(1826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1866)..(1866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1916)..(1916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1923)..(1923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1976)..(1976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1990)..(1990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2000)..(2000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2015)..(2015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2024)..(2024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2033)..(2033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2048)..(2048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2078)..(2078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2099)..(2099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2102)..(2102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2127)..(2127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2164)..(2164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2181)..(2181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2200)..(2200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2208)..(2208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2248)..(2248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2274)..(2274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2301)..(2301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2312)..(2312)
<223> Selenocysteine

<400> 4726
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Pro  Ile Met Asn His Asn  Pro Trp Met Leu Leu  Tyr Phe Ile 
    1505                 1510                 1515             


Ser Phe  Leu Leu Ile Val Ala  Phe Phe Val Leu Asn  Met Phe Val 
    1520                 1525                 1530             


Gly Val  Val Val Glu Asn Phe  His Lys Cys Arg Gln  His Gln Glu 
    1535                 1540                 1545             


Glu Glu  Glu Ala Arg Arg Arg  Glu Glu Lys Arg Leu  Arg Arg Leu 
    1550                 1555                 1560             


Glu Lys  Lys Arg Arg Ser Lys  Glu Lys Gln Met Ala  Glu Ala Gln 
    1565                 1570                 1575             


Cys Lys  Pro Tyr Tyr Ser Asp  Tyr Ser Arg Phe Arg  Leu Leu Val 
    1580                 1585                 1590             


His His  Leu Cys Xaa Ser His  Tyr Leu Asp Leu Phe  Ile Xaa Gly 
    1595                 1600                 1605             


Val Ile  Gly Leu Asn Val Val  Xaa Met Ala Met Glu  His Tyr Gln 
    1610                 1615                 1620             


Gln Pro  Gln Ile Leu Asp Glu  Ala Leu Lys Ile Cys  Asn Tyr Ile 
    1625                 1630                 1635             


Phe Xaa  Val Ile Phe Val Leu  Glu Ser Val Phe Lys  Leu Val Ala 
    1640                 1645                 1650             


Phe Gly  Phe Arg Arg Phe Phe  Gln Asp Arg Trp Asn  Gln Leu Asp 
    1655                 1660                 1665             


Leu Ala  Ile Val Leu Leu Ser  Ile Met Gly Ile Xaa  Leu Glu Glu 
    1670                 1675                 1680             


Ile Glu  Val Asn Ala Ser Leu  Pro Ile Asn Pro Xaa  Ile Ile Arg 
    1685                 1690                 1695             


Ile Met  Arg Val Leu Arg Ile  Ala Arg Val Leu Lys  Leu Leu Lys 
    1700                 1705                 1710             


Met Ala  Val Gly Met Arg Ala  Leu Leu Asp Xaa Val  Met Gln Ala 
    1715                 1720                 1725             


Leu Pro  Gln Val Gly Asn Leu  Gly Leu Leu Phe Met  Leu Leu Phe 
    1730                 1735                 1740             


Phe Ile  Phe Ala Ala Leu Gly  Val Glu Leu Phe Gly  Asp Leu Glu 
    1745                 1750                 1755             


Cys Asp  Glu Xaa His Pro Cys  Glu Gly Leu Gly Arg  His Ala Xaa 
    1760                 1765                 1770             


Phe Arg  Asn Phe Gly Met Ala  Phe Leu Xaa Leu Phe  Arg Val Ser 
    1775                 1780                 1785             


Xaa Gly  Asp Asn Trp Asn Gly  Ile Met Lys Asp Xaa  Leu Arg Asp 
    1790                 1795                 1800             


Cys Asp  Gln Glu Ser Xaa Cys  Tyr Asn Xaa Val Ile  Ser Pro Ile 
    1805                 1810                 1815             


Tyr Phe  Val Ser Phe Val Leu  Xaa Ala Gln Phe Val  Leu Val Asn 
    1820                 1825                 1830             


Val Val  Ile Ala Val Leu Met  Lys His Leu Glu Glu  Ser Asn Lys 
    1835                 1840                 1845             


Glu Ala  Lys Glu Glu Ala Glu  Leu Glu Ala Glu Leu  Glu Leu Glu 
    1850                 1855                 1860             


Met Lys  Xaa Leu Ser Pro Gln  Pro His Ser Pro Leu  Gly Ser Pro 
    1865                 1870                 1875             


Phe Leu  Trp Pro Gly Val Glu  Gly Pro Asp Ser Pro  Asp Ser Pro 
    1880                 1885                 1890             


Lys Pro  Gly Ala Leu His Pro  Ala Ala His Ala Arg  Ser Ala Ser 
    1895                 1900                 1905             


His Phe  Ser Leu Glu His Pro  Xaa Asp Arg Gln Leu  Phe Asp Xaa 
    1910                 1915                 1920             


Ile Ser  Leu Leu Ile Gln Gly  Ser Leu Glu Trp Glu  Leu Lys Leu 
    1925                 1930                 1935             


Met Asp  Glu Leu Ala Gly Pro  Gly Gly Gln Pro Ser  Ala Phe Pro 
    1940                 1945                 1950             


Ser Ala  Pro Ser Leu Gly Gly  Ser Asp Pro Gln Ile  Pro Leu Ala 
    1955                 1960                 1965             


Glu Met  Glu Ala Leu Ser Leu  Xaa Ser Glu Ile Val  Ser Glu Pro 
    1970                 1975                 1980             


Ser Cys  Ser Leu Ala Leu Xaa  Asp Asp Ser Leu Pro  Asp Asp Met 
    1985                 1990                 1995             


His Xaa  Leu Leu Leu Ser Ala  Leu Glu Ser Asn Met  Gln Pro His 
    2000                 2005                 2010             


Pro Xaa  Glu Leu Pro Gly Pro  Asp Leu Leu Xaa Val  Arg Lys Ser 
    2015                 2020                 2025             


Gly Val  Ser Arg Xaa His Ser  Leu Pro Asn Asp Ser  Tyr Met Cys 
    2030                 2035                 2040             


Arg His  Gly Ser Xaa Ala Glu  Gly Pro Leu Gly His  Arg Gly Trp 
    2045                 2050                 2055             


Gly Leu  Pro Lys Ala Gln Ser  Gly Ser Val Leu Ser  Val His Ser 
    2060                 2065                 2070             


Gln Pro  Ala Asp Xaa Ser Tyr  Ile Leu Gln Leu Pro  Lys Asp Ala 
    2075                 2080                 2085             


Pro His  Leu Leu Gln Pro His  Ser Ala Pro Xaa Trp  Gly Xaa Ile 
    2090                 2095                 2100             


Pro Lys  Leu Pro Pro Pro Gly  Arg Ser Pro Leu Ala  Gln Arg Pro 
    2105                 2110                 2115             


Leu Arg  Arg Gln Ala Ala Ile  Arg Xaa Asp Ser Leu  Asp Val Gln 
    2120                 2125                 2130             


Gly Leu  Gly Ser Arg Glu Asp  Leu Leu Ala Glu Val  Ser Gly Pro 
    2135                 2140                 2145             


Ser Pro  Pro Leu Ala Arg Ala  Tyr Ser Phe Trp Gly  Gln Ser Ser 
    2150                 2155                 2160             


Xaa Gln  Ala Gln Gln His Ser  Arg Ser His Ser Lys  Ile Ser Lys 
    2165                 2170                 2175             


His Met  Xaa Pro Pro Ala Pro  Cys Pro Gly Pro Glu  Pro Asn Trp 
    2180                 2185                 2190             


Gly Lys  Gly Pro Pro Glu Xaa  Arg Ser Ser Leu Glu  Leu Asp Xaa 
    2195                 2200                 2205             


Glu Leu  Ser Trp Ile Ser Gly  Asp Leu Leu Pro Pro  Gly Gly Gln 
    2210                 2215                 2220             


Glu Glu  Pro Pro Ser Pro Arg  Asp Leu Lys Lys Cys  Tyr Ser Val 
    2225                 2230                 2235             


Glu Ala  Gln Ser Cys Gln Arg  Arg Pro Xaa Ser Trp  Leu Asp Glu 
    2240                 2245                 2250             


Gln Arg  Arg His Ser Ile Ala  Val Ser Cys Leu Asp  Ser Gly Ser 
    2255                 2260                 2265             


Gln Pro  His Leu Gly Xaa Asp  Pro Ser Asn Leu Gly  Gly Gln Pro 
    2270                 2275                 2280             


Leu Gly  Gly Pro Gly Ser Arg  Pro Lys Lys Lys Leu  Ser Pro Pro 
    2285                 2290                 2295             


Ser Ile  Xaa Ile Asp Pro Pro  Glu Ser Gln Gly Pro  Arg Xaa Pro 
    2300                 2305                 2310             


Pro Ser  Pro Gly Ile Cys Leu  Arg Arg Arg Ala Pro  Ser Ser Asp 
    2315                 2320                 2325             


Ser Lys  Asp Pro Leu Ala Ser  Gly Pro Pro Asp Ser  Met Ala Ala 
    2330                 2335                 2340             


Ser Pro  Ser Pro Lys Lys Asp  Val Leu Ser Leu Ser  Gly Leu Ser 
    2345                 2350                 2355             


Ser Asp  Pro Ala Asp Leu Asp  Pro 
    2360                 2365     


<210> 4727
<211> 2377
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1446)..(1446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1618)..(1618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1627)..(1627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1651)..(1651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1691)..(1691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1706)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1735)..(1735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1784)..(1784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1794)..(1794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1800)..(1800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1811)..(1811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1820)..(1820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1824)..(1824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1837)..(1837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1877)..(1877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1927)..(1927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1934)..(1934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1987)..(1987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2001)..(2001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2011)..(2011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2026)..(2026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2035)..(2035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2044)..(2044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2059)..(2059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2089)..(2089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2110)..(2110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2113)..(2113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2138)..(2138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2175)..(2175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2192)..(2192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2211)..(2211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2219)..(2219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2259)..(2259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2285)..(2285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2312)..(2312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2323)..(2323)
<223> Selenocysteine

<400> 4727
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Xaa Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Xaa Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Xaa Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Xaa Leu Leu Leu Asp Xaa Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Xaa Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Xaa Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Xaa Xaa Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Xaa Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Xaa 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln Phe Ser Glu 
385                 390                 395                 400 


Xaa Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Xaa Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Xaa Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Xaa Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Xaa Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Xaa Val Gly Ser Gly Lys Val Tyr Pro Xaa 
            580                 585                 590         


Val His Xaa Ser Pro Pro Pro Glu Xaa Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Xaa Leu Xaa Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Xaa Gln Ser 
625                 630                 635                 640 


Xaa Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Xaa Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Xaa Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Xaa Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Xaa Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Xaa Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Xaa Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Xaa Met Asp Asn 
    850                 855                 860                 


Val Ala Xaa Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Xaa Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Xaa Val Phe Gln Ile Leu Xaa Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Xaa Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Xaa Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Xaa Ala Ala  Xaa Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Xaa Ser  Xaa Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Xaa Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Xaa Leu Gln Val  Pro Gly Leu His Arg  Xaa Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Xaa His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Xaa Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Xaa Leu Ser Asn Tyr  Ile Phe Xaa Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Xaa Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Xaa Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Xaa  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Xaa Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Xaa Arg Asn Ile Xaa  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Pro  Ile Met Asn His Asn  Pro Trp Met Leu Leu  Tyr Phe Ile 
    1505                 1510                 1515             


Ser Phe  Leu Leu Ile Val Ala  Phe Phe Val Leu Asn  Met Phe Val 
    1520                 1525                 1530             


Gly Val  Val Val Glu Asn Phe  His Lys Cys Arg Gln  His Gln Glu 
    1535                 1540                 1545             


Glu Glu  Glu Ala Arg Arg Arg  Glu Glu Lys Arg Leu  Arg Arg Leu 
    1550                 1555                 1560             


Glu Lys  Lys Arg Arg Asn Leu  Met Leu Asp Asp Val  Ile Ala Ser 
    1565                 1570                 1575             


Gly Ser  Ser Ala Ser Ala Ala  Ser Glu Ala Gln Cys  Lys Pro Tyr 
    1580                 1585                 1590             


Tyr Ser  Asp Tyr Ser Arg Phe  Arg Leu Leu Val His  His Leu Cys 
    1595                 1600                 1605             


Xaa Ser  His Tyr Leu Asp Leu  Phe Ile Xaa Gly Val  Ile Gly Leu 
    1610                 1615                 1620             


Asn Val  Val Xaa Met Ala Met  Glu His Tyr Gln Gln  Pro Gln Ile 
    1625                 1630                 1635             


Leu Asp  Glu Ala Leu Lys Ile  Cys Asn Tyr Ile Phe  Xaa Val Ile 
    1640                 1645                 1650             


Phe Val  Leu Glu Ser Val Phe  Lys Leu Val Ala Phe  Gly Phe Arg 
    1655                 1660                 1665             


Arg Phe  Phe Gln Asp Arg Trp  Asn Gln Leu Asp Leu  Ala Ile Val 
    1670                 1675                 1680             


Leu Leu  Ser Ile Met Gly Ile  Xaa Leu Glu Glu Ile  Glu Val Asn 
    1685                 1690                 1695             


Ala Ser  Leu Pro Ile Asn Pro  Xaa Ile Ile Arg Ile  Met Arg Val 
    1700                 1705                 1710             


Leu Arg  Ile Ala Arg Val Leu  Lys Leu Leu Lys Met  Ala Val Gly 
    1715                 1720                 1725             


Met Arg  Ala Leu Leu Asp Xaa  Val Met Gln Ala Leu  Pro Gln Val 
    1730                 1735                 1740             


Gly Asn  Leu Gly Leu Leu Phe  Met Leu Leu Phe Phe  Ile Phe Ala 
    1745                 1750                 1755             


Ala Leu  Gly Val Glu Leu Phe  Gly Asp Leu Glu Cys  Asp Glu Xaa 
    1760                 1765                 1770             


His Pro  Cys Glu Gly Leu Gly  Arg His Ala Xaa Phe  Arg Asn Phe 
    1775                 1780                 1785             


Gly Met  Ala Phe Leu Xaa Leu  Phe Arg Val Ser Xaa  Gly Asp Asn 
    1790                 1795                 1800             


Trp Asn  Gly Ile Met Lys Asp  Xaa Leu Arg Asp Cys  Asp Gln Glu 
    1805                 1810                 1815             


Ser Xaa  Cys Tyr Asn Xaa Val  Ile Ser Pro Ile Tyr  Phe Val Ser 
    1820                 1825                 1830             


Phe Val  Leu Xaa Ala Gln Phe  Val Leu Val Asn Val  Val Ile Ala 
    1835                 1840                 1845             


Val Leu  Met Lys His Leu Glu  Glu Ser Asn Lys Glu  Ala Lys Glu 
    1850                 1855                 1860             


Glu Ala  Glu Leu Glu Ala Glu  Leu Glu Leu Glu Met  Lys Xaa Leu 
    1865                 1870                 1875             


Ser Pro  Gln Pro His Ser Pro  Leu Gly Ser Pro Phe  Leu Trp Pro 
    1880                 1885                 1890             


Gly Val  Glu Gly Pro Asp Ser  Pro Asp Ser Pro Lys  Pro Gly Ala 
    1895                 1900                 1905             


Leu His  Pro Ala Ala His Ala  Arg Ser Ala Ser His  Phe Ser Leu 
    1910                 1915                 1920             


Glu His  Pro Xaa Asp Arg Gln  Leu Phe Asp Xaa Ile  Ser Leu Leu 
    1925                 1930                 1935             


Ile Gln  Gly Ser Leu Glu Trp  Glu Leu Lys Leu Met  Asp Glu Leu 
    1940                 1945                 1950             


Ala Gly  Pro Gly Gly Gln Pro  Ser Ala Phe Pro Ser  Ala Pro Ser 
    1955                 1960                 1965             


Leu Gly  Gly Ser Asp Pro Gln  Ile Pro Leu Ala Glu  Met Glu Ala 
    1970                 1975                 1980             


Leu Ser  Leu Xaa Ser Glu Ile  Val Ser Glu Pro Ser  Cys Ser Leu 
    1985                 1990                 1995             


Ala Leu  Xaa Asp Asp Ser Leu  Pro Asp Asp Met His  Xaa Leu Leu 
    2000                 2005                 2010             


Leu Ser  Ala Leu Glu Ser Asn  Met Gln Pro His Pro  Xaa Glu Leu 
    2015                 2020                 2025             


Pro Gly  Pro Asp Leu Leu Xaa  Val Arg Lys Ser Gly  Val Ser Arg 
    2030                 2035                 2040             


Xaa His  Ser Leu Pro Asn Asp  Ser Tyr Met Cys Arg  His Gly Ser 
    2045                 2050                 2055             


Xaa Ala  Glu Gly Pro Leu Gly  His Arg Gly Trp Gly  Leu Pro Lys 
    2060                 2065                 2070             


Ala Gln  Ser Gly Ser Val Leu  Ser Val His Ser Gln  Pro Ala Asp 
    2075                 2080                 2085             


Xaa Ser  Tyr Ile Leu Gln Leu  Pro Lys Asp Ala Pro  His Leu Leu 
    2090                 2095                 2100             


Gln Pro  His Ser Ala Pro Xaa  Trp Gly Xaa Ile Pro  Lys Leu Pro 
    2105                 2110                 2115             


Pro Pro  Gly Arg Ser Pro Leu  Ala Gln Arg Pro Leu  Arg Arg Gln 
    2120                 2125                 2130             


Ala Ala  Ile Arg Xaa Asp Ser  Leu Asp Val Gln Gly  Leu Gly Ser 
    2135                 2140                 2145             


Arg Glu  Asp Leu Leu Ala Glu  Val Ser Gly Pro Ser  Pro Pro Leu 
    2150                 2155                 2160             


Ala Arg  Ala Tyr Ser Phe Trp  Gly Gln Ser Ser Xaa  Gln Ala Gln 
    2165                 2170                 2175             


Gln His  Ser Arg Ser His Ser  Lys Ile Ser Lys His  Met Xaa Pro 
    2180                 2185                 2190             


Pro Ala  Pro Cys Pro Gly Pro  Glu Pro Asn Trp Gly  Lys Gly Pro 
    2195                 2200                 2205             


Pro Glu  Xaa Arg Ser Ser Leu  Glu Leu Asp Xaa Glu  Leu Ser Trp 
    2210                 2215                 2220             


Ile Ser  Gly Asp Leu Leu Pro  Pro Gly Gly Gln Glu  Glu Pro Pro 
    2225                 2230                 2235             


Ser Pro  Arg Asp Leu Lys Lys  Cys Tyr Ser Val Glu  Ala Gln Ser 
    2240                 2245                 2250             


Cys Gln  Arg Arg Pro Xaa Ser  Trp Leu Asp Glu Gln  Arg Arg His 
    2255                 2260                 2265             


Ser Ile  Ala Val Ser Cys Leu  Asp Ser Gly Ser Gln  Pro His Leu 
    2270                 2275                 2280             


Gly Xaa  Asp Pro Ser Asn Leu  Gly Gly Gln Pro Leu  Gly Gly Pro 
    2285                 2290                 2295             


Gly Ser  Arg Pro Lys Lys Lys  Leu Ser Pro Pro Ser  Ile Xaa Ile 
    2300                 2305                 2310             


Asp Pro  Pro Glu Ser Gln Gly  Pro Arg Xaa Pro Pro  Ser Pro Gly 
    2315                 2320                 2325             


Ile Cys  Leu Arg Arg Arg Ala  Pro Ser Ser Asp Ser  Lys Asp Pro 
    2330                 2335                 2340             


Leu Ala  Ser Gly Pro Pro Asp  Ser Met Ala Ala Ser  Pro Ser Pro 
    2345                 2350                 2355             


Lys Lys  Asp Val Leu Ser Leu  Ser Gly Leu Ser Ser  Asp Pro Ala 
    2360                 2365                 2370             


Asp Leu  Asp Pro 
    2375         


<210> 4728
<211> 337
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<400> 4728
Xaa Ala Ser Gly Arg Gly Ser Ala Ser Glu His Gln Asp Cys Asn Gly 
1               5                   10                  15      


Lys Ser Ala Ser Gly Arg Leu Ala Arg Ala Leu Arg Pro Asp Asp Pro 
            20                  25                  30          


Pro Leu Asp Gly Asp Asp Ala Asp Asp Glu Gly Asn Leu Ser Lys Gly 
        35                  40                  45              


Glu Arg Val Arg Ala Trp Ile Arg Ala Arg Leu Pro Ala Cys Cys Leu 
    50                  55                  60                  


Glu Arg Asp Ser Trp Ser Ala Tyr Ile Phe Pro Pro Gln Ser Arg Phe 
65                  70                  75                  80  


Arg Leu Leu Cys His Arg Ile Ile Xaa His Lys Met Phe Asp His Val 
                85                  90                  95      


Val Leu Val Ile Ile Phe Leu Asn Cys Ile Xaa Ile Ala Met Glu Arg 
            100                 105                 110         


Pro Lys Ile Asp Pro His Ser Ala Glu Arg Ile Phe Leu Xaa Leu Ser 
        115                 120                 125             


Asn Tyr Ile Phe Xaa Ala Val Phe Leu Ala Glu Met Xaa Val Lys Val 
    130                 135                 140                 


Val Ala Leu Gly Trp Cys Phe Gly Glu Gln Ala Tyr Leu Arg Ser Ser 
145                 150                 155                 160 


Trp Asn Val Leu Asp Gly Leu Leu Val Leu Ile Ser Val Ile Asp Ile 
                165                 170                 175     


Leu Val Ser Met Val Ser Asp Ser Gly Xaa Lys Ile Leu Gly Met Leu 
            180                 185                 190         


Arg Val Leu Arg Leu Leu Arg Xaa Leu Arg Pro Leu Arg Val Ile Ser 
        195                 200                 205             


Arg Ala Gln Gly Leu Lys Leu Val Val Glu Xaa Leu Met Ser Ser Leu 
    210                 215                 220                 


Lys Pro Ile Gly Asn Ile Val Val Ile Cys Cys Ala Phe Phe Ile Ile 
225                 230                 235                 240 


Phe Gly Ile Leu Gly Val Gln Leu Phe Lys Gly Lys Phe Phe Val Cys 
                245                 250                 255     


Gln Gly Glu Asp Xaa Arg Asn Ile Xaa Asn Lys Ser Asp Cys Ala Glu 
            260                 265                 270         


Ala Ser Tyr Arg Trp Val Arg His Lys Tyr Asn Phe Asp Asn Leu Gly 
        275                 280                 285             


Gln Ala Leu Met Ser Leu Phe Val Leu Ala Ser Lys Asp Gly Trp Val 
    290                 295                 300                 


Asp Ile Met Tyr Asp Gly Leu Asp Ala Val Gly Val Asp Gln Gln Val 
305                 310                 315                 320 


Gly Leu Arg Trp Ala Gly Ser Ile Cys Gly Leu Arg Ser Leu Ser Met 
                325                 330                 335     


Gly 
    


<210> 4729
<211> 1981
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1244)..(1244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1366)..(1366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1437)..(1437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1459)..(1459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1478)..(1478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1482)..(1482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1492)..(1493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1532)..(1532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1576)..(1576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1625)..(1625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1635)..(1635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1641)..(1641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1652)..(1652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1681)..(1681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1731)..(1731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1750)..(1750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1784)..(1784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1818)..(1818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1843)..(1843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1877)..(1877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1945)..(1945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1947)..(1947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1949)..(1949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1970)..(1970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1977)..(1977)
<223> Selenocysteine

<400> 4729
Met Ala Glu Ser Ala Ser Pro Pro Ser Ser Ser Ala Ala Ala Pro Ala 
1               5                   10                  15      


Ala Glu Pro Gly Val Xaa Xaa Glu Gln Pro Gly Pro Arg Ser Pro Pro 
            20                  25                  30          


Ser Ser Pro Pro Gly Leu Glu Glu Pro Leu Asp Gly Ala Asp Pro His 
        35                  40                  45              


Val Pro His Pro Asp Leu Ala Pro Ile Ala Phe Phe Cys Leu Arg Gln 
    50                  55                  60                  


Xaa Xaa Ser Pro Arg Asn Trp Cys Ile Lys Met Val Cys Asn Pro Trp 
65                  70                  75                  80  


Phe Glu Cys Val Ser Met Leu Val Ile Leu Leu Asn Cys Val Xaa Leu 
                85                  90                  95      


Gly Met Tyr Gln Pro Cys Asp Asp Met Asp Cys Leu Ser Asp Arg Cys 
            100                 105                 110         


Lys Ile Leu Gln Val Phe Asp Asp Phe Ile Phe Ile Phe Phe Ala Met 
        115                 120                 125             


Glu Met Val Leu Lys Met Val Ala Leu Gly Ile Phe Gly Lys Lys Cys 
    130                 135                 140                 


Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val Met Ala 
145                 150                 155                 160 


Gly Met Val Glu Tyr Ser Leu Asp Leu Gln Asn Ile Asn Leu Ser Ala 
                165                 170                 175     


Ile Arg Xaa Val Arg Val Leu Arg Pro Leu Lys Ala Ile Asn Arg Val 
            180                 185                 190         


Pro Ser Met Arg Ile Leu Val Asn Leu Leu Leu Asp Xaa Leu Pro Met 
        195                 200                 205             


Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile Phe Gly 
    210                 215                 220                 


Ile Ile Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg Cys Phe 
225                 230                 235                 240 


Leu Glu Glu Asn Phe Xaa Ile Gln Gly Asp Val Ala Leu Pro Pro Tyr 
                245                 250                 255     


Tyr Gln Pro Glu Glu Asp Asp Glu Met Pro Phe Ile Cys Ser Leu Ser 
            260                 265                 270         


Gly Asp Asn Gly Ile Met Gly Cys His Glu Ile Pro Pro Leu Lys Glu 
        275                 280                 285             


Gln Gly Arg Glu Cys Cys Leu Ser Lys Asp Asp Val Tyr Asp Phe Gly 
    290                 295                 300                 


Ala Gly Arg Gln Asp Leu Asn Ala Ser Gly Leu Cys Val Asn Trp Asn 
305                 310                 315                 320 


Arg Tyr Tyr Asn Val Cys Arg Xaa Gly Ser Ala Asn Pro His Lys Gly 
                325                 330                 335     


Ala Ile Asn Phe Asp Asn Ile Gly Tyr Ala Trp Ile Val Ile Phe Gln 
            340                 345                 350         


Val Ile Xaa Leu Glu Gly Trp Val Glu Ile Met Tyr Tyr Val Met Asp 
        355                 360                 365             


Ala His Ser Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val 
    370                 375                 380                 


Gly Ser Phe Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln 
385                 390                 395                 400 


Phe Ser Glu Xaa Lys Gln Arg Glu His Arg Leu Met Leu Glu Gln Arg 
                405                 410                 415     


Gln Arg Tyr Leu Ser Ser Ser Xaa Val Ala Ser Tyr Ala Glu Pro Gly 
            420                 425                 430         


Asp Cys Tyr Glu Glu Ile Phe Gln Tyr Val Cys His Ile Leu Arg Lys 
        435                 440                 445             


Ala Lys Arg Arg Ala Leu Gly Leu Tyr Gln Ala Leu Gln Ser Arg Arg 
    450                 455                 460                 


Gln Ala Leu Gly Pro Glu Ala Pro Ala Pro Ala Lys Pro Gly Pro His 
465                 470                 475                 480 


Ala Lys Glu Pro Arg His Tyr Gln Leu Cys Pro Gln His Ser Pro Leu 
                485                 490                 495     


Asp Ala Xaa Pro His Xaa Leu Val Gln Pro Ile Pro Ala Xaa Leu Ala 
            500                 505                 510         


Ser Asp Pro Ala Ser Cys Pro Cys Cys Gln His Glu Asp Gly Arg Arg 
        515                 520                 525             


Pro Ser Gly Leu Gly Ser Xaa Asp Ser Gly Gln Glu Gly Ser Gly Ser 
    530                 535                 540                 


Gly Ser Ser Ala Gly Gly Glu Asp Glu Ala Asp Gly Asp Gly Ala Arg 
545                 550                 555                 560 


Ser Ser Glu Asp Gly Ala Ser Ser Glu Leu Gly Lys Glu Glu Glu Glu 
                565                 570                 575     


Glu Glu Gln Ala Asp Gly Ala Val Trp Leu Cys Gly Asp Val Trp Arg 
            580                 585                 590         


Glu Xaa Arg Ala Lys Leu Arg Gly Ile Val Asp Ser Lys Tyr Phe Asn 
        595                 600                 605             


Arg Gly Ile Met Met Ala Ile Leu Val Asn Xaa Val Ser Met Gly Ile 
    610                 615                 620                 


Glu His His Glu Gln Pro Glu Glu Leu Xaa Asn Ile Leu Glu Ile Cys 
625                 630                 635                 640 


Asn Val Val Phe Xaa Ser Met Phe Ala Leu Glu Met Ile Leu Lys Leu 
                645                 650                 655     


Ala Ala Phe Gly Leu Phe Asp Tyr Leu Arg Asn Pro Tyr Asn Ile Phe 
            660                 665                 670         


Asp Ser Ile Ile Val Ile Ile Ser Ile Trp Glu Ile Val Gly Gln Ala 
        675                 680                 685             


Asp Gly Gly Leu Ser Val Leu Arg Xaa Phe Arg Leu Leu Arg Val Leu 
    690                 695                 700                 


Lys Leu Val Arg Phe Met Pro Ala Leu Arg Arg Gln Leu Val Val Leu 
705                 710                 715                 720 


Met Lys Xaa Met Asp Asn Val Ala Xaa Phe Cys Met Leu Leu Met Leu 
                725                 730                 735     


Phe Ile Phe Ile Phe Ser Ile Leu Gly Met His Ile Phe Gly Cys Lys 
            740                 745                 750         


Phe Ser Leu Arg Xaa Asp Xaa Gly Asp Xaa Val Pro Asp Arg Lys Asn 
        755                 760                 765             


Phe Asp Ser Leu Leu Trp Ala Ile Val Xaa Val Phe Gln Ile Leu Xaa 
    770                 775                 780                 


Gln Glu Asp Trp Asn Val Val Leu Tyr Asn Gly Met Ala Ser Xaa Ser 
785                 790                 795                 800 


Pro Trp Ala Ser Leu Tyr Phe Val Ala Leu Met Xaa Phe Gly Asn Tyr 
                805                 810                 815     


Val Leu Phe Asn Leu Leu Val Ala Ile Leu Val Glu Gly Phe Gln Ala 
            820                 825                 830         


Glu Gly Asp Ala Asn Arg Ser Tyr Ser Asp Glu Asp Gln Ser Ser Ser 
        835                 840                 845             


Asn Ile Glu Glu Phe Asp Lys Leu Gln Glu Gly Leu Asp Ser Ser Gly 
    850                 855                 860                 


Asp Pro Lys Leu Cys Pro Ile Pro Met Xaa Pro Asn Gly His Leu Asp 
865                 870                 875                 880 


Pro Ser Leu Pro Leu Gly Gly His Leu Gly Pro Ala Gly Ala Ala Gly 
                885                 890                 895     


Pro Ala Pro Arg Leu Ser Leu Gln Pro Asp Pro Met Leu Val Ala Leu 
            900                 905                 910         


Gly Ser Arg Lys Ser Ser Val Met Ser Leu Gly Arg Met Ser Tyr Asp 
        915                 920                 925             


Gln Arg Ser Leu Ser Ser Ser Arg Ser Ser Tyr Tyr Gly Pro Trp Gly 
    930                 935                 940                 


Arg Ser Ala Ala Trp Ala Ser Arg Arg Ser Ser Trp Asn Ser Leu Lys 
945                 950                 955                 960 


His Lys Pro Pro Ser Ala Glu His Glu Ser Leu Leu Ser Ala Glu Arg 
                965                 970                 975     


Gly Gly Gly Ala Arg Val Cys Glu Val Ala Ala Asp Glu Gly Pro Pro 
            980                 985                 990         


Arg Ala Ala Pro Leu His Xaa Pro  His Ala His His Ile  His His Gly 
        995                 1000                 1005             


Pro His  Leu Ala His Arg His  Arg His His Arg Arg  Xaa Leu Ser 
    1010                 1015                 1020             


Leu Asp  Asn Arg Asp Ser Val  Asp Leu Ala Glu Leu  Val Pro Ala 
    1025                 1030                 1035             


Val Gly  Ala His Pro Arg Ala  Ala Trp Arg Ala Ala  Gly Pro Ala 
    1040                 1045                 1050             


Pro Gly  His Glu Asp Cys Asn  Gly Arg Met Pro Ser  Ile Ala Lys 
    1055                 1060                 1065             


Asp Val  Phe Xaa Lys Met Gly  Asp Arg Gly Asp Arg  Gly Glu Asp 
    1070                 1075                 1080             


Glu Glu  Glu Ile Asp Tyr Xaa  Leu Cys Phe Arg Val  Arg Lys Met 
    1085                 1090                 1095             


Ile Asp  Val Tyr Lys Pro Asp  Trp Cys Glu Val Arg  Glu Asp Trp 
    1100                 1105                 1110             


Ser Val  Tyr Leu Phe Ser Pro  Glu Asn Arg Phe Arg  Val Leu Cys 
    1115                 1120                 1125             


Gln Xaa  Ile Ile Ala His Lys  Leu Phe Asp Tyr Val  Val Leu Ala 
    1130                 1135                 1140             


Phe Ile  Phe Leu Asn Cys Ile  Xaa Ile Ala Leu Glu  Arg Pro Gln 
    1145                 1150                 1155             


Ile Glu  Ala Gly Ser Xaa Glu  Arg Ile Phe Leu Xaa  Val Ser Asn 
    1160                 1165                 1170             


Tyr Ile  Phe Xaa Ala Ile Phe  Val Gly Glu Met Xaa  Leu Lys Val 
    1175                 1180                 1185             


Val Ser  Leu Gly Leu Tyr Phe  Gly Glu Gln Ala Tyr  Leu Arg Ser 
    1190                 1195                 1200             


Ser Trp  Asn Val Leu Asp Gly  Phe Leu Val Phe Val  Ser Ile Ile 
    1205                 1210                 1215             


Asp Ile  Val Val Ser Leu Ala  Ser Ala Gly Gly Ala  Lys Ile Leu 
    1220                 1225                 1230             


Gly Val  Leu Arg Val Leu Arg  Leu Leu Arg Xaa Leu  Arg Pro Leu 
    1235                 1240                 1245             


Arg Val  Ile Ser Arg Ala Pro  Gly Leu Lys Leu Val  Val Glu Xaa 
    1250                 1255                 1260             


Leu Ile  Ser Ser Leu Lys Pro  Ile Gly Asn Ile Val  Leu Ile Cys 
    1265                 1270                 1275             


Cys Ala  Phe Phe Ile Ile Phe  Gly Ile Leu Gly Val  Gln Leu Phe 
    1280                 1285                 1290             


Lys Gly  Lys Phe Tyr His Cys  Leu Gly Val Asp Xaa  Arg Asn Ile 
    1295                 1300                 1305             


Xaa Asn  Arg Ser Asp Cys Met  Ala Ala Asn Tyr Arg  Trp Val His 
    1310                 1315                 1320             


His Lys  Tyr Asn Phe Asp Asn  Leu Gly Gln Ala Leu  Met Ser Leu 
    1325                 1330                 1335             


Phe Val  Leu Ala Ser Lys Asp  Gly Trp Val Asn Ile  Met Tyr Asn 
    1340                 1345                 1350             


Gly Leu  Asp Ala Val Ala Val  Asp Gln Gln Pro Val  Xaa Asn His 
    1355                 1360                 1365             


Asn Pro  Trp Met Leu Leu Tyr  Phe Ile Ser Phe Leu  Leu Ile Val 
    1370                 1375                 1380             


Ser Phe  Phe Val Leu Asn Met  Phe Val Gly Val Val  Val Glu Asn 
    1385                 1390                 1395             


Phe His  Lys Cys Arg Gln His  Gln Glu Ala Glu Glu  Ala Arg Arg 
    1400                 1405                 1410             


Arg Glu  Glu Lys Arg Leu Arg  Arg Leu Glu Lys Lys  Arg Arg Lys 
    1415                 1420                 1425             


Ala Gln  Arg Leu Pro Tyr Tyr  Ala Xaa Tyr Cys His  Xaa Arg Leu 
    1430                 1435                 1440             


Leu Ile  His Ser Met Cys Xaa  Ser His Tyr Leu Asp  Ile Phe Ile 
    1445                 1450                 1455             


Xaa Phe  Ile Ile Cys Leu Asn  Val Val Xaa Met Ser  Leu Glu His 
    1460                 1465                 1470             


Tyr Asn  Gln Pro Xaa Ser Leu  Glu Xaa Ala Leu Lys  Tyr Cys Asn 
    1475                 1480                 1485             


Tyr Met  Phe Xaa Xaa Val Phe  Val Leu Glu Ala Val  Leu Lys Leu 
    1490                 1495                 1500             


Val Ala  Phe Gly Leu Arg Arg  Phe Phe Lys Asp Arg  Trp Asn Gln 
    1505                 1510                 1515             


Leu Asp  Leu Ala Ile Val Leu  Leu Ser Val Met Gly  Ile Xaa Leu 
    1520                 1525                 1530             


Glu Glu  Ile Glu Ile Asn Ala  Ala Leu Pro Ile Asn  Pro Xaa Ile 
    1535                 1540                 1545             


Ile Arg  Ile Met Arg Val Leu  Arg Ile Ala Arg Val  Leu Lys Leu 
    1550                 1555                 1560             


Leu Lys  Met Ala Xaa Gly Met  Arg Ala Leu Leu Asp  Xaa Val Val 
    1565                 1570                 1575             


Gln Ala  Leu Pro Gln Val Gly  Asn Leu Gly Leu Leu  Phe Met Leu 
    1580                 1585                 1590             


Leu Phe  Phe Ile Tyr Ala Ala  Leu Gly Val Glu Leu  Phe Gly Lys 
    1595                 1600                 1605             


Leu Val  Cys Asn Asp Glu Asn  Pro Cys Glu Gly Met  Ser Arg His 
    1610                 1615                 1620             


Ala Xaa  Phe Glu Asn Phe Gly  Met Ala Phe Leu Xaa  Leu Phe Gln 
    1625                 1630                 1635             


Val Ser  Xaa Gly Asp Asn Trp  Asn Gly Ile Met Lys  Asp Xaa Leu 
    1640                 1645                 1650             


Arg Asp  Cys Xaa His Asp Glu  Arg Ser Cys Leu Ser  Ser Leu Gln 
    1655                 1660                 1665             


Phe Val  Ser Pro Leu Tyr Phe  Val Ser Phe Val Leu  Xaa Ala Gln 
    1670                 1675                 1680             


Phe Val  Leu Ile Asn Val Val  Val Ala Val Leu Met  Lys His Leu 
    1685                 1690                 1695             


Asp Asp  Ser Asn Lys Glu Ala  Gln Glu Asp Ala Glu  Met Asp Ala 
    1700                 1705                 1710             


Glu Leu  Glu Leu Glu Met Ala  His Gly Leu Gly Pro  Gly Pro Arg 
    1715                 1720                 1725             


Leu Pro  Xaa Gly Ser Pro Gly  Ala Pro Gly Arg Gly  Pro Gly Gly 
    1730                 1735                 1740             


Ala Gly  Gly Gly Gly Asp Xaa  Glu Gly Gly Leu Cys  Arg Arg Cys 
    1745                 1750                 1755             


Tyr Ser  Pro Ala Gln Glu Asn  Leu Trp Leu Asp Ser  Val Ser Leu 
    1760                 1765                 1770             


Ile Ile  Lys Asp Ser Leu Glu  Gly Glu Leu Xaa Ile  Ile Asp Asn 
    1775                 1780                 1785             


Leu Ser  Gly Ser Ile Phe His  His Tyr Ser Ser Pro  Ala Gly Cys 
    1790                 1795                 1800             


Lys Lys  Cys His His Asp Lys  Gln Glu Val Gln Leu  Ala Glu Xaa 
    1805                 1810                 1815             


Glu Ala  Phe Ser Leu Asn Ser  Asp Arg Ser Ser Ser  Ile Leu Leu 
    1820                 1825                 1830             


Gly Asp  Asp Leu Ser Leu Glu  Asp Pro Xaa Ala Cys  Pro Pro Gly 
    1835                 1840                 1845             


Arg Lys  Asp Ser Lys Gly Glu  Leu Asp Pro Pro Glu  Pro Met Arg 
    1850                 1855                 1860             


Val Gly  Asp Leu Gly Glu Cys  Phe Phe Pro Leu Ser  Ser Xaa Ala 
    1865                 1870                 1875             


Val Ser  Pro Asp Pro Glu Asn  Phe Leu Cys Glu Met  Glu Glu Ile 
    1880                 1885                 1890             


Pro Phe  Asn Pro Val Arg Ser  Trp Leu Lys His Asp  Ser Ser Gln 
    1895                 1900                 1905             


Ala Pro  Pro Ser Pro Phe Ser  Pro Asp Ala Ser Ser  Pro Leu Leu 
    1910                 1915                 1920             


Pro Met  Pro Ala Glu Phe Phe  His Pro Ala Val Ser  Ala Ser Gln 
    1925                 1930                 1935             


Lys Gly  Pro Glu Lys Gly Xaa  Gly Xaa Gly Xaa Leu  Pro Lys Ile 
    1940                 1945                 1950             


Ala Leu  Gln Gly Ser Trp Ala  Ser Leu Arg Ser Pro  Arg Val Asn 
    1955                 1960                 1965             


Cys Xaa  Leu Leu Arg Gln Val  Pro Xaa Pro Pro Arg  Pro 
    1970                 1975                 1980     


<210> 4730
<211> 2016
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1107)..(1107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1298)..(1298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1340)..(1340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1344)..(1344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1476)..(1476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1485)..(1485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1494)..(1494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1503)..(1503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1517)..(1517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1527)..(1528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1567)..(1567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1603)..(1603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1611)..(1611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1660)..(1660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1670)..(1670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1676)..(1676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1687)..(1687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1692)..(1692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1716)..(1716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1766)..(1766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1785)..(1785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1819)..(1819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1853)..(1853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1878)..(1878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1912)..(1912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1980)..(1980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1982)..(1982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1984)..(1984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2005)..(2005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2012)..(2012)
<223> Selenocysteine

<400> 4730
Met Ala Glu Ser Ala Ser Pro Pro Ser Ser Ser Ala Ala Ala Pro Ala 
1               5                   10                  15      


Ala Glu Pro Gly Val Xaa Xaa Glu Gln Pro Gly Pro Arg Ser Pro Pro 
            20                  25                  30          


Ser Ser Pro Pro Gly Leu Glu Glu Pro Leu Asp Gly Ala Asp Pro His 
        35                  40                  45              


Val Pro His Pro Asp Leu Ala Pro Ile Ala Phe Phe Cys Leu Arg Gln 
    50                  55                  60                  


Xaa Xaa Ser Pro Arg Asn Trp Cys Ile Lys Met Val Cys Asn Pro Trp 
65                  70                  75                  80  


Phe Glu Cys Val Ser Met Leu Val Ile Leu Leu Asn Cys Val Xaa Leu 
                85                  90                  95      


Gly Met Tyr Gln Pro Cys Asp Asp Met Asp Cys Leu Ser Asp Arg Cys 
            100                 105                 110         


Lys Ile Leu Gln Val Phe Asp Asp Phe Ile Phe Ile Phe Phe Ala Met 
        115                 120                 125             


Glu Met Val Leu Lys Met Val Ala Leu Gly Ile Phe Gly Lys Lys Cys 
    130                 135                 140                 


Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val Met Ala 
145                 150                 155                 160 


Gly Met Val Glu Tyr Ser Leu Asp Leu Gln Asn Ile Asn Leu Ser Ala 
                165                 170                 175     


Ile Arg Xaa Val Arg Val Leu Arg Pro Leu Lys Ala Ile Asn Arg Val 
            180                 185                 190         


Pro Ser Met Arg Ile Leu Val Asn Leu Leu Leu Asp Xaa Leu Pro Met 
        195                 200                 205             


Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile Phe Gly 
    210                 215                 220                 


Ile Ile Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg Cys Phe 
225                 230                 235                 240 


Leu Glu Glu Asn Phe Xaa Ile Gln Gly Asp Val Ala Leu Pro Pro Tyr 
                245                 250                 255     


Tyr Gln Pro Glu Glu Asp Asp Glu Met Pro Phe Ile Cys Ser Leu Ser 
            260                 265                 270         


Gly Asp Asn Gly Ile Met Gly Cys His Glu Ile Pro Pro Leu Lys Glu 
        275                 280                 285             


Gln Gly Arg Glu Cys Cys Leu Ser Lys Asp Asp Val Tyr Asp Phe Gly 
    290                 295                 300                 


Ala Gly Arg Gln Asp Leu Asn Ala Ser Gly Leu Cys Val Asn Trp Asn 
305                 310                 315                 320 


Arg Tyr Tyr Asn Val Cys Arg Xaa Gly Ser Ala Asn Pro His Lys Gly 
                325                 330                 335     


Ala Ile Asn Phe Asp Asn Ile Gly Tyr Ala Trp Ile Val Ile Phe Gln 
            340                 345                 350         


Val Ile Xaa Leu Glu Gly Trp Val Glu Ile Met Tyr Tyr Val Met Asp 
        355                 360                 365             


Ala His Ser Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val 
    370                 375                 380                 


Gly Ser Phe Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln 
385                 390                 395                 400 


Phe Ser Glu Xaa Lys Gln Arg Glu His Arg Leu Met Leu Glu Gln Arg 
                405                 410                 415     


Gln Arg Tyr Leu Ser Ser Ser Xaa Val Ala Ser Tyr Ala Glu Pro Gly 
            420                 425                 430         


Asp Cys Tyr Glu Glu Ile Phe Gln Tyr Val Cys His Ile Leu Arg Lys 
        435                 440                 445             


Ala Lys Arg Arg Ala Leu Gly Leu Tyr Gln Ala Leu Gln Ser Arg Arg 
    450                 455                 460                 


Gln Ala Leu Gly Pro Glu Ala Pro Ala Pro Ala Lys Pro Gly Pro His 
465                 470                 475                 480 


Ala Lys Glu Pro Arg His Tyr His Gly Lys Xaa Lys Gly Gln Gly Asp 
                485                 490                 495     


Glu Gly Arg His Leu Gly Ser Arg His Cys Gln Xaa Leu His Gly Pro 
            500                 505                 510         


Ala Ser Pro Gly Asn Asp His Ser Gly Arg Glu Leu Cys Pro Gln His 
        515                 520                 525             


Ser Pro Leu Asp Ala Xaa Pro His Xaa Leu Val Gln Pro Ile Pro Ala 
    530                 535                 540                 


Xaa Leu Ala Ser Asp Pro Ala Ser Cys Pro Cys Cys Gln His Glu Asp 
545                 550                 555                 560 


Gly Arg Arg Pro Ser Gly Leu Gly Ser Xaa Asp Ser Gly Gln Glu Gly 
                565                 570                 575     


Ser Gly Ser Gly Ser Ser Ala Gly Gly Glu Asp Glu Ala Asp Gly Asp 
            580                 585                 590         


Gly Ala Arg Ser Ser Glu Asp Gly Ala Ser Ser Glu Leu Gly Lys Glu 
        595                 600                 605             


Glu Glu Glu Glu Glu Gln Ala Asp Gly Ala Val Trp Leu Cys Gly Asp 
    610                 615                 620                 


Val Trp Arg Glu Xaa Arg Ala Lys Leu Arg Gly Ile Val Asp Ser Lys 
625                 630                 635                 640 


Tyr Phe Asn Arg Gly Ile Met Met Ala Ile Leu Val Asn Xaa Val Ser 
                645                 650                 655     


Met Gly Ile Glu His His Glu Gln Pro Glu Glu Leu Xaa Asn Ile Leu 
            660                 665                 670         


Glu Ile Cys Asn Val Val Phe Xaa Ser Met Phe Ala Leu Glu Met Ile 
        675                 680                 685             


Leu Lys Leu Ala Ala Phe Gly Leu Phe Asp Tyr Leu Arg Asn Pro Tyr 
    690                 695                 700                 


Asn Ile Phe Asp Ser Ile Ile Val Ile Ile Ser Ile Trp Glu Ile Val 
705                 710                 715                 720 


Gly Gln Ala Asp Gly Gly Leu Ser Val Leu Arg Xaa Phe Arg Leu Leu 
                725                 730                 735     


Arg Val Leu Lys Leu Val Arg Phe Met Pro Ala Leu Arg Arg Gln Leu 
            740                 745                 750         


Val Val Leu Met Lys Xaa Met Asp Asn Val Ala Xaa Phe Cys Met Leu 
        755                 760                 765             


Leu Met Leu Phe Ile Phe Ile Phe Ser Ile Leu Gly Met His Ile Phe 
    770                 775                 780                 


Gly Cys Lys Phe Ser Leu Arg Xaa Asp Xaa Gly Asp Xaa Val Pro Asp 
785                 790                 795                 800 


Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala Ile Val Xaa Val Phe Gln 
                805                 810                 815     


Ile Leu Xaa Gln Glu Asp Trp Asn Val Val Leu Tyr Asn Gly Met Ala 
            820                 825                 830         


Ser Xaa Ser Pro Trp Ala Ser Leu Tyr Phe Val Ala Leu Met Xaa Phe 
        835                 840                 845             


Gly Asn Tyr Val Leu Phe Asn Leu Leu Val Ala Ile Leu Val Glu Gly 
    850                 855                 860                 


Phe Gln Ala Glu Gly Asp Ala Asn Arg Ser Tyr Ser Asp Glu Asp Gln 
865                 870                 875                 880 


Ser Ser Ser Asn Ile Glu Glu Phe Asp Lys Leu Gln Glu Gly Leu Asp 
                885                 890                 895     


Ser Ser Gly Asp Pro Lys Leu Cys Pro Ile Pro Met Xaa Pro Asn Gly 
            900                 905                 910         


His Leu Asp Pro Ser Leu Pro Leu Gly Gly His Leu Gly Pro Ala Gly 
        915                 920                 925             


Ala Ala Gly Pro Ala Pro Arg Leu Ser Leu Gln Pro Asp Pro Met Leu 
    930                 935                 940                 


Val Ala Leu Gly Ser Arg Lys Ser Ser Val Met Ser Leu Gly Arg Met 
945                 950                 955                 960 


Ser Tyr Asp Gln Arg Ser Leu Ser Ser Ser Arg Ser Ser Tyr Tyr Gly 
                965                 970                 975     


Pro Trp Gly Arg Ser Ala Ala Trp Ala Ser Arg Arg Ser Ser Trp Asn 
            980                 985                 990         


Ser Leu Lys His Lys Pro Pro Ser  Ala Glu His Glu Ser  Leu Leu Ser 
        995                 1000                 1005             


Ala Glu  Arg Gly Gly Gly Ala  Arg Val Cys Glu Val  Ala Ala Asp 
    1010                 1015                 1020             


Glu Gly  Pro Pro Arg Ala Ala  Pro Leu His Xaa Pro  His Ala His 
    1025                 1030                 1035             


His Ile  His His Gly Pro His  Leu Ala His Arg His  Arg His His 
    1040                 1045                 1050             


Arg Arg  Xaa Leu Ser Leu Asp  Asn Arg Asp Ser Val  Asp Leu Ala 
    1055                 1060                 1065             


Glu Leu  Val Pro Ala Val Gly  Ala His Pro Arg Ala  Ala Trp Arg 
    1070                 1075                 1080             


Ala Ala  Gly Pro Ala Pro Gly  His Glu Asp Cys Asn  Gly Arg Met 
    1085                 1090                 1095             


Pro Ser  Ile Ala Lys Asp Val  Phe Xaa Lys Met Gly  Asp Arg Gly 
    1100                 1105                 1110             


Asp Arg  Gly Glu Asp Glu Glu  Glu Ile Asp Tyr Xaa  Leu Cys Phe 
    1115                 1120                 1125             


Arg Val  Arg Lys Met Ile Asp  Val Tyr Lys Pro Asp  Trp Cys Glu 
    1130                 1135                 1140             


Val Arg  Glu Asp Trp Ser Val  Tyr Leu Phe Ser Pro  Glu Asn Arg 
    1145                 1150                 1155             


Phe Arg  Val Leu Cys Gln Xaa  Ile Ile Ala His Lys  Leu Phe Asp 
    1160                 1165                 1170             


Tyr Val  Val Leu Ala Phe Ile  Phe Leu Asn Cys Ile  Xaa Ile Ala 
    1175                 1180                 1185             


Leu Glu  Arg Pro Gln Ile Glu  Ala Gly Ser Xaa Glu  Arg Ile Phe 
    1190                 1195                 1200             


Leu Xaa  Val Ser Asn Tyr Ile  Phe Xaa Ala Ile Phe  Val Gly Glu 
    1205                 1210                 1215             


Met Xaa  Leu Lys Val Val Ser  Leu Gly Leu Tyr Phe  Gly Glu Gln 
    1220                 1225                 1230             


Ala Tyr  Leu Arg Ser Ser Trp  Asn Val Leu Asp Gly  Phe Leu Val 
    1235                 1240                 1245             


Phe Val  Ser Ile Ile Asp Ile  Val Val Ser Leu Ala  Ser Ala Gly 
    1250                 1255                 1260             


Gly Ala  Lys Ile Leu Gly Val  Leu Arg Val Leu Arg  Leu Leu Arg 
    1265                 1270                 1275             


Xaa Leu  Arg Pro Leu Arg Val  Ile Ser Arg Ala Pro  Gly Leu Lys 
    1280                 1285                 1290             


Leu Val  Val Glu Xaa Leu Ile  Ser Ser Leu Lys Pro  Ile Gly Asn 
    1295                 1300                 1305             


Ile Val  Leu Ile Cys Cys Ala  Phe Phe Ile Ile Phe  Gly Ile Leu 
    1310                 1315                 1320             


Gly Val  Gln Leu Phe Lys Gly  Lys Phe Tyr His Cys  Leu Gly Val 
    1325                 1330                 1335             


Asp Xaa  Arg Asn Ile Xaa Asn  Arg Ser Asp Cys Met  Ala Ala Asn 
    1340                 1345                 1350             


Tyr Arg  Trp Val His His Lys  Tyr Asn Phe Asp Asn  Leu Gly Gln 
    1355                 1360                 1365             


Ala Leu  Met Ser Leu Phe Val  Leu Ala Ser Lys Asp  Gly Trp Val 
    1370                 1375                 1380             


Asn Ile  Met Tyr Asn Gly Leu  Asp Ala Val Ala Val  Asp Gln Gln 
    1385                 1390                 1395             


Pro Val  Xaa Asn His Asn Pro  Trp Met Leu Leu Tyr  Phe Ile Ser 
    1400                 1405                 1410             


Phe Leu  Leu Ile Val Ser Phe  Phe Val Leu Asn Met  Phe Val Gly 
    1415                 1420                 1425             


Val Val  Val Glu Asn Phe His  Lys Cys Arg Gln His  Gln Glu Ala 
    1430                 1435                 1440             


Glu Glu  Ala Arg Arg Arg Glu  Glu Lys Arg Leu Arg  Arg Leu Glu 
    1445                 1450                 1455             


Lys Lys  Arg Arg Lys Ala Gln  Arg Leu Pro Tyr Tyr  Ala Xaa Tyr 
    1460                 1465                 1470             


Cys His  Xaa Arg Leu Leu Ile  His Ser Met Cys Xaa  Ser His Tyr 
    1475                 1480                 1485             


Leu Asp  Ile Phe Ile Xaa Phe  Ile Ile Cys Leu Asn  Val Val Xaa 
    1490                 1495                 1500             


Met Ser  Leu Glu His Tyr Asn  Gln Pro Xaa Ser Leu  Glu Xaa Ala 
    1505                 1510                 1515             


Leu Lys  Tyr Cys Asn Tyr Met  Phe Xaa Xaa Val Phe  Val Leu Glu 
    1520                 1525                 1530             


Ala Val  Leu Lys Leu Val Ala  Phe Gly Leu Arg Arg  Phe Phe Lys 
    1535                 1540                 1545             


Asp Arg  Trp Asn Gln Leu Asp  Leu Ala Ile Val Leu  Leu Ser Val 
    1550                 1555                 1560             


Met Gly  Ile Xaa Leu Glu Glu  Ile Glu Ile Asn Ala  Ala Leu Pro 
    1565                 1570                 1575             


Ile Asn  Pro Xaa Ile Ile Arg  Ile Met Arg Val Leu  Arg Ile Ala 
    1580                 1585                 1590             


Arg Val  Leu Lys Leu Leu Lys  Met Ala Xaa Gly Met  Arg Ala Leu 
    1595                 1600                 1605             


Leu Asp  Xaa Val Val Gln Ala  Leu Pro Gln Val Gly  Asn Leu Gly 
    1610                 1615                 1620             


Leu Leu  Phe Met Leu Leu Phe  Phe Ile Tyr Ala Ala  Leu Gly Val 
    1625                 1630                 1635             


Glu Leu  Phe Gly Lys Leu Val  Cys Asn Asp Glu Asn  Pro Cys Glu 
    1640                 1645                 1650             


Gly Met  Ser Arg His Ala Xaa  Phe Glu Asn Phe Gly  Met Ala Phe 
    1655                 1660                 1665             


Leu Xaa  Leu Phe Gln Val Ser  Xaa Gly Asp Asn Trp  Asn Gly Ile 
    1670                 1675                 1680             


Met Lys  Asp Xaa Leu Arg Asp  Cys Xaa His Asp Glu  Arg Ser Cys 
    1685                 1690                 1695             


Leu Ser  Ser Leu Gln Phe Val  Ser Pro Leu Tyr Phe  Val Ser Phe 
    1700                 1705                 1710             


Val Leu  Xaa Ala Gln Phe Val  Leu Ile Asn Val Val  Val Ala Val 
    1715                 1720                 1725             


Leu Met  Lys His Leu Asp Asp  Ser Asn Lys Glu Ala  Gln Glu Asp 
    1730                 1735                 1740             


Ala Glu  Met Asp Ala Glu Leu  Glu Leu Glu Met Ala  His Gly Leu 
    1745                 1750                 1755             


Gly Pro  Gly Pro Arg Leu Pro  Xaa Gly Ser Pro Gly  Ala Pro Gly 
    1760                 1765                 1770             


Arg Gly  Pro Gly Gly Ala Gly  Gly Gly Gly Asp Xaa  Glu Gly Gly 
    1775                 1780                 1785             


Leu Cys  Arg Arg Cys Tyr Ser  Pro Ala Gln Glu Asn  Leu Trp Leu 
    1790                 1795                 1800             


Asp Ser  Val Ser Leu Ile Ile  Lys Asp Ser Leu Glu  Gly Glu Leu 
    1805                 1810                 1815             


Xaa Ile  Ile Asp Asn Leu Ser  Gly Ser Ile Phe His  His Tyr Ser 
    1820                 1825                 1830             


Ser Pro  Ala Gly Cys Lys Lys  Cys His His Asp Lys  Gln Glu Val 
    1835                 1840                 1845             


Gln Leu  Ala Glu Xaa Glu Ala  Phe Ser Leu Asn Ser  Asp Arg Ser 
    1850                 1855                 1860             


Ser Ser  Ile Leu Leu Gly Asp  Asp Leu Ser Leu Glu  Asp Pro Xaa 
    1865                 1870                 1875             


Ala Cys  Pro Pro Gly Arg Lys  Asp Ser Lys Gly Glu  Leu Asp Pro 
    1880                 1885                 1890             


Pro Glu  Pro Met Arg Val Gly  Asp Leu Gly Glu Cys  Phe Phe Pro 
    1895                 1900                 1905             


Leu Ser  Ser Xaa Ala Val Ser  Pro Asp Pro Glu Asn  Phe Leu Cys 
    1910                 1915                 1920             


Glu Met  Glu Glu Ile Pro Phe  Asn Pro Val Arg Ser  Trp Leu Lys 
    1925                 1930                 1935             


His Asp  Ser Ser Gln Ala Pro  Pro Ser Pro Phe Ser  Pro Asp Ala 
    1940                 1945                 1950             


Ser Ser  Pro Leu Leu Pro Met  Pro Ala Glu Phe Phe  His Pro Ala 
    1955                 1960                 1965             


Val Ser  Ala Ser Gln Lys Gly  Pro Glu Lys Gly Xaa  Gly Xaa Gly 
    1970                 1975                 1980             


Xaa Leu  Pro Lys Ile Ala Leu  Gln Gly Ser Trp Ala  Ser Leu Arg 
    1985                 1990                 1995             


Ser Pro  Arg Val Asn Cys Xaa  Leu Leu Arg Gln Val  Pro Xaa Pro 
    2000                 2005                 2010             


Pro Arg  Pro 
    2015     


<210> 4731
<211> 2188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1244)..(1244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1366)..(1366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1437)..(1437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1459)..(1459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1478)..(1478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1482)..(1482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1492)..(1493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1532)..(1532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1576)..(1576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1625)..(1625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1635)..(1635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1641)..(1641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1652)..(1652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1681)..(1681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1731)..(1731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1750)..(1750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1784)..(1784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1818)..(1818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1843)..(1843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1877)..(1877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1945)..(1945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1947)..(1947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1949)..(1949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1970)..(1970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1976)..(1976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1980)..(1980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1995)..(1996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2002)..(2002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2058)..(2058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2063)..(2063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2091)..(2091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2098)..(2098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2113)..(2113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2121)..(2121)
<223> Selenocysteine

<400> 4731
Met Ala Glu Ser Ala Ser Pro Pro Ser Ser Ser Ala Ala Ala Pro Ala 
1               5                   10                  15      


Ala Glu Pro Gly Val Xaa Xaa Glu Gln Pro Gly Pro Arg Ser Pro Pro 
            20                  25                  30          


Ser Ser Pro Pro Gly Leu Glu Glu Pro Leu Asp Gly Ala Asp Pro His 
        35                  40                  45              


Val Pro His Pro Asp Leu Ala Pro Ile Ala Phe Phe Cys Leu Arg Gln 
    50                  55                  60                  


Xaa Xaa Ser Pro Arg Asn Trp Cys Ile Lys Met Val Cys Asn Pro Trp 
65                  70                  75                  80  


Phe Glu Cys Val Ser Met Leu Val Ile Leu Leu Asn Cys Val Xaa Leu 
                85                  90                  95      


Gly Met Tyr Gln Pro Cys Asp Asp Met Asp Cys Leu Ser Asp Arg Cys 
            100                 105                 110         


Lys Ile Leu Gln Val Phe Asp Asp Phe Ile Phe Ile Phe Phe Ala Met 
        115                 120                 125             


Glu Met Val Leu Lys Met Val Ala Leu Gly Ile Phe Gly Lys Lys Cys 
    130                 135                 140                 


Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val Met Ala 
145                 150                 155                 160 


Gly Met Val Glu Tyr Ser Leu Asp Leu Gln Asn Ile Asn Leu Ser Ala 
                165                 170                 175     


Ile Arg Xaa Val Arg Val Leu Arg Pro Leu Lys Ala Ile Asn Arg Val 
            180                 185                 190         


Pro Ser Met Arg Ile Leu Val Asn Leu Leu Leu Asp Xaa Leu Pro Met 
        195                 200                 205             


Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile Phe Gly 
    210                 215                 220                 


Ile Ile Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg Cys Phe 
225                 230                 235                 240 


Leu Glu Glu Asn Phe Xaa Ile Gln Gly Asp Val Ala Leu Pro Pro Tyr 
                245                 250                 255     


Tyr Gln Pro Glu Glu Asp Asp Glu Met Pro Phe Ile Cys Ser Leu Ser 
            260                 265                 270         


Gly Asp Asn Gly Ile Met Gly Cys His Glu Ile Pro Pro Leu Lys Glu 
        275                 280                 285             


Gln Gly Arg Glu Cys Cys Leu Ser Lys Asp Asp Val Tyr Asp Phe Gly 
    290                 295                 300                 


Ala Gly Arg Gln Asp Leu Asn Ala Ser Gly Leu Cys Val Asn Trp Asn 
305                 310                 315                 320 


Arg Tyr Tyr Asn Val Cys Arg Xaa Gly Ser Ala Asn Pro His Lys Gly 
                325                 330                 335     


Ala Ile Asn Phe Asp Asn Ile Gly Tyr Ala Trp Ile Val Ile Phe Gln 
            340                 345                 350         


Val Ile Xaa Leu Glu Gly Trp Val Glu Ile Met Tyr Tyr Val Met Asp 
        355                 360                 365             


Ala His Ser Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val 
    370                 375                 380                 


Gly Ser Phe Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln 
385                 390                 395                 400 


Phe Ser Glu Xaa Lys Gln Arg Glu His Arg Leu Met Leu Glu Gln Arg 
                405                 410                 415     


Gln Arg Tyr Leu Ser Ser Ser Xaa Val Ala Ser Tyr Ala Glu Pro Gly 
            420                 425                 430         


Asp Cys Tyr Glu Glu Ile Phe Gln Tyr Val Cys His Ile Leu Arg Lys 
        435                 440                 445             


Ala Lys Arg Arg Ala Leu Gly Leu Tyr Gln Ala Leu Gln Ser Arg Arg 
    450                 455                 460                 


Gln Ala Leu Gly Pro Glu Ala Pro Ala Pro Ala Lys Pro Gly Pro His 
465                 470                 475                 480 


Ala Lys Glu Pro Arg His Tyr Gln Leu Cys Pro Gln His Ser Pro Leu 
                485                 490                 495     


Asp Ala Xaa Pro His Xaa Leu Val Gln Pro Ile Pro Ala Xaa Leu Ala 
            500                 505                 510         


Ser Asp Pro Ala Ser Cys Pro Cys Cys Gln His Glu Asp Gly Arg Arg 
        515                 520                 525             


Pro Ser Gly Leu Gly Ser Xaa Asp Ser Gly Gln Glu Gly Ser Gly Ser 
    530                 535                 540                 


Gly Ser Ser Ala Gly Gly Glu Asp Glu Ala Asp Gly Asp Gly Ala Arg 
545                 550                 555                 560 


Ser Ser Glu Asp Gly Ala Ser Ser Glu Leu Gly Lys Glu Glu Glu Glu 
                565                 570                 575     


Glu Glu Gln Ala Asp Gly Ala Val Trp Leu Cys Gly Asp Val Trp Arg 
            580                 585                 590         


Glu Xaa Arg Ala Lys Leu Arg Gly Ile Val Asp Ser Lys Tyr Phe Asn 
        595                 600                 605             


Arg Gly Ile Met Met Ala Ile Leu Val Asn Xaa Val Ser Met Gly Ile 
    610                 615                 620                 


Glu His His Glu Gln Pro Glu Glu Leu Xaa Asn Ile Leu Glu Ile Cys 
625                 630                 635                 640 


Asn Val Val Phe Xaa Ser Met Phe Ala Leu Glu Met Ile Leu Lys Leu 
                645                 650                 655     


Ala Ala Phe Gly Leu Phe Asp Tyr Leu Arg Asn Pro Tyr Asn Ile Phe 
            660                 665                 670         


Asp Ser Ile Ile Val Ile Ile Ser Ile Trp Glu Ile Val Gly Gln Ala 
        675                 680                 685             


Asp Gly Gly Leu Ser Val Leu Arg Xaa Phe Arg Leu Leu Arg Val Leu 
    690                 695                 700                 


Lys Leu Val Arg Phe Met Pro Ala Leu Arg Arg Gln Leu Val Val Leu 
705                 710                 715                 720 


Met Lys Xaa Met Asp Asn Val Ala Xaa Phe Cys Met Leu Leu Met Leu 
                725                 730                 735     


Phe Ile Phe Ile Phe Ser Ile Leu Gly Met His Ile Phe Gly Cys Lys 
            740                 745                 750         


Phe Ser Leu Arg Xaa Asp Xaa Gly Asp Xaa Val Pro Asp Arg Lys Asn 
        755                 760                 765             


Phe Asp Ser Leu Leu Trp Ala Ile Val Xaa Val Phe Gln Ile Leu Xaa 
    770                 775                 780                 


Gln Glu Asp Trp Asn Val Val Leu Tyr Asn Gly Met Ala Ser Xaa Ser 
785                 790                 795                 800 


Pro Trp Ala Ser Leu Tyr Phe Val Ala Leu Met Xaa Phe Gly Asn Tyr 
                805                 810                 815     


Val Leu Phe Asn Leu Leu Val Ala Ile Leu Val Glu Gly Phe Gln Ala 
            820                 825                 830         


Glu Gly Asp Ala Asn Arg Ser Tyr Ser Asp Glu Asp Gln Ser Ser Ser 
        835                 840                 845             


Asn Ile Glu Glu Phe Asp Lys Leu Gln Glu Gly Leu Asp Ser Ser Gly 
    850                 855                 860                 


Asp Pro Lys Leu Cys Pro Ile Pro Met Xaa Pro Asn Gly His Leu Asp 
865                 870                 875                 880 


Pro Ser Leu Pro Leu Gly Gly His Leu Gly Pro Ala Gly Ala Ala Gly 
                885                 890                 895     


Pro Ala Pro Arg Leu Ser Leu Gln Pro Asp Pro Met Leu Val Ala Leu 
            900                 905                 910         


Gly Ser Arg Lys Ser Ser Val Met Ser Leu Gly Arg Met Ser Tyr Asp 
        915                 920                 925             


Gln Arg Ser Leu Ser Ser Ser Arg Ser Ser Tyr Tyr Gly Pro Trp Gly 
    930                 935                 940                 


Arg Ser Ala Ala Trp Ala Ser Arg Arg Ser Ser Trp Asn Ser Leu Lys 
945                 950                 955                 960 


His Lys Pro Pro Ser Ala Glu His Glu Ser Leu Leu Ser Ala Glu Arg 
                965                 970                 975     


Gly Gly Gly Ala Arg Val Cys Glu Val Ala Ala Asp Glu Gly Pro Pro 
            980                 985                 990         


Arg Ala Ala Pro Leu His Xaa Pro  His Ala His His Ile  His His Gly 
        995                 1000                 1005             


Pro His  Leu Ala His Arg His  Arg His His Arg Arg  Xaa Leu Ser 
    1010                 1015                 1020             


Leu Asp  Asn Arg Asp Ser Val  Asp Leu Ala Glu Leu  Val Pro Ala 
    1025                 1030                 1035             


Val Gly  Ala His Pro Arg Ala  Ala Trp Arg Ala Ala  Gly Pro Ala 
    1040                 1045                 1050             


Pro Gly  His Glu Asp Cys Asn  Gly Arg Met Pro Ser  Ile Ala Lys 
    1055                 1060                 1065             


Asp Val  Phe Xaa Lys Met Gly  Asp Arg Gly Asp Arg  Gly Glu Asp 
    1070                 1075                 1080             


Glu Glu  Glu Ile Asp Tyr Xaa  Leu Cys Phe Arg Val  Arg Lys Met 
    1085                 1090                 1095             


Ile Asp  Val Tyr Lys Pro Asp  Trp Cys Glu Val Arg  Glu Asp Trp 
    1100                 1105                 1110             


Ser Val  Tyr Leu Phe Ser Pro  Glu Asn Arg Phe Arg  Val Leu Cys 
    1115                 1120                 1125             


Gln Xaa  Ile Ile Ala His Lys  Leu Phe Asp Tyr Val  Val Leu Ala 
    1130                 1135                 1140             


Phe Ile  Phe Leu Asn Cys Ile  Xaa Ile Ala Leu Glu  Arg Pro Gln 
    1145                 1150                 1155             


Ile Glu  Ala Gly Ser Xaa Glu  Arg Ile Phe Leu Xaa  Val Ser Asn 
    1160                 1165                 1170             


Tyr Ile  Phe Xaa Ala Ile Phe  Val Gly Glu Met Xaa  Leu Lys Val 
    1175                 1180                 1185             


Val Ser  Leu Gly Leu Tyr Phe  Gly Glu Gln Ala Tyr  Leu Arg Ser 
    1190                 1195                 1200             


Ser Trp  Asn Val Leu Asp Gly  Phe Leu Val Phe Val  Ser Ile Ile 
    1205                 1210                 1215             


Asp Ile  Val Val Ser Leu Ala  Ser Ala Gly Gly Ala  Lys Ile Leu 
    1220                 1225                 1230             


Gly Val  Leu Arg Val Leu Arg  Leu Leu Arg Xaa Leu  Arg Pro Leu 
    1235                 1240                 1245             


Arg Val  Ile Ser Arg Ala Pro  Gly Leu Lys Leu Val  Val Glu Xaa 
    1250                 1255                 1260             


Leu Ile  Ser Ser Leu Lys Pro  Ile Gly Asn Ile Val  Leu Ile Cys 
    1265                 1270                 1275             


Cys Ala  Phe Phe Ile Ile Phe  Gly Ile Leu Gly Val  Gln Leu Phe 
    1280                 1285                 1290             


Lys Gly  Lys Phe Tyr His Cys  Leu Gly Val Asp Xaa  Arg Asn Ile 
    1295                 1300                 1305             


Xaa Asn  Arg Ser Asp Cys Met  Ala Ala Asn Tyr Arg  Trp Val His 
    1310                 1315                 1320             


His Lys  Tyr Asn Phe Asp Asn  Leu Gly Gln Ala Leu  Met Ser Leu 
    1325                 1330                 1335             


Phe Val  Leu Ala Ser Lys Asp  Gly Trp Val Asn Ile  Met Tyr Asn 
    1340                 1345                 1350             


Gly Leu  Asp Ala Val Ala Val  Asp Gln Gln Pro Val  Xaa Asn His 
    1355                 1360                 1365             


Asn Pro  Trp Met Leu Leu Tyr  Phe Ile Ser Phe Leu  Leu Ile Val 
    1370                 1375                 1380             


Ser Phe  Phe Val Leu Asn Met  Phe Val Gly Val Val  Val Glu Asn 
    1385                 1390                 1395             


Phe His  Lys Cys Arg Gln His  Gln Glu Ala Glu Glu  Ala Arg Arg 
    1400                 1405                 1410             


Arg Glu  Glu Lys Arg Leu Arg  Arg Leu Glu Lys Lys  Arg Arg Lys 
    1415                 1420                 1425             


Ala Gln  Arg Leu Pro Tyr Tyr  Ala Xaa Tyr Cys His  Xaa Arg Leu 
    1430                 1435                 1440             


Leu Ile  His Ser Met Cys Xaa  Ser His Tyr Leu Asp  Ile Phe Ile 
    1445                 1450                 1455             


Xaa Phe  Ile Ile Cys Leu Asn  Val Val Xaa Met Ser  Leu Glu His 
    1460                 1465                 1470             


Tyr Asn  Gln Pro Xaa Ser Leu  Glu Xaa Ala Leu Lys  Tyr Cys Asn 
    1475                 1480                 1485             


Tyr Met  Phe Xaa Xaa Val Phe  Val Leu Glu Ala Val  Leu Lys Leu 
    1490                 1495                 1500             


Val Ala  Phe Gly Leu Arg Arg  Phe Phe Lys Asp Arg  Trp Asn Gln 
    1505                 1510                 1515             


Leu Asp  Leu Ala Ile Val Leu  Leu Ser Val Met Gly  Ile Xaa Leu 
    1520                 1525                 1530             


Glu Glu  Ile Glu Ile Asn Ala  Ala Leu Pro Ile Asn  Pro Xaa Ile 
    1535                 1540                 1545             


Ile Arg  Ile Met Arg Val Leu  Arg Ile Ala Arg Val  Leu Lys Leu 
    1550                 1555                 1560             


Leu Lys  Met Ala Xaa Gly Met  Arg Ala Leu Leu Asp  Xaa Val Val 
    1565                 1570                 1575             


Gln Ala  Leu Pro Gln Val Gly  Asn Leu Gly Leu Leu  Phe Met Leu 
    1580                 1585                 1590             


Leu Phe  Phe Ile Tyr Ala Ala  Leu Gly Val Glu Leu  Phe Gly Lys 
    1595                 1600                 1605             


Leu Val  Cys Asn Asp Glu Asn  Pro Cys Glu Gly Met  Ser Arg His 
    1610                 1615                 1620             


Ala Xaa  Phe Glu Asn Phe Gly  Met Ala Phe Leu Xaa  Leu Phe Gln 
    1625                 1630                 1635             


Val Ser  Xaa Gly Asp Asn Trp  Asn Gly Ile Met Lys  Asp Xaa Leu 
    1640                 1645                 1650             


Arg Asp  Cys Xaa His Asp Glu  Arg Ser Cys Leu Ser  Ser Leu Gln 
    1655                 1660                 1665             


Phe Val  Ser Pro Leu Tyr Phe  Val Ser Phe Val Leu  Xaa Ala Gln 
    1670                 1675                 1680             


Phe Val  Leu Ile Asn Val Val  Val Ala Val Leu Met  Lys His Leu 
    1685                 1690                 1695             


Asp Asp  Ser Asn Lys Glu Ala  Gln Glu Asp Ala Glu  Met Asp Ala 
    1700                 1705                 1710             


Glu Leu  Glu Leu Glu Met Ala  His Gly Leu Gly Pro  Gly Pro Arg 
    1715                 1720                 1725             


Leu Pro  Xaa Gly Ser Pro Gly  Ala Pro Gly Arg Gly  Pro Gly Gly 
    1730                 1735                 1740             


Ala Gly  Gly Gly Gly Asp Xaa  Glu Gly Gly Leu Cys  Arg Arg Cys 
    1745                 1750                 1755             


Tyr Ser  Pro Ala Gln Glu Asn  Leu Trp Leu Asp Ser  Val Ser Leu 
    1760                 1765                 1770             


Ile Ile  Lys Asp Ser Leu Glu  Gly Glu Leu Xaa Ile  Ile Asp Asn 
    1775                 1780                 1785             


Leu Ser  Gly Ser Ile Phe His  His Tyr Ser Ser Pro  Ala Gly Cys 
    1790                 1795                 1800             


Lys Lys  Cys His His Asp Lys  Gln Glu Val Gln Leu  Ala Glu Xaa 
    1805                 1810                 1815             


Glu Ala  Phe Ser Leu Asn Ser  Asp Arg Ser Ser Ser  Ile Leu Leu 
    1820                 1825                 1830             


Gly Asp  Asp Leu Ser Leu Glu  Asp Pro Xaa Ala Cys  Pro Pro Gly 
    1835                 1840                 1845             


Arg Lys  Asp Ser Lys Gly Glu  Leu Asp Pro Pro Glu  Pro Met Arg 
    1850                 1855                 1860             


Val Gly  Asp Leu Gly Glu Cys  Phe Phe Pro Leu Ser  Ser Xaa Ala 
    1865                 1870                 1875             


Val Ser  Pro Asp Pro Glu Asn  Phe Leu Cys Glu Met  Glu Glu Ile 
    1880                 1885                 1890             


Pro Phe  Asn Pro Val Arg Ser  Trp Leu Lys His Asp  Ser Ser Gln 
    1895                 1900                 1905             


Ala Pro  Pro Ser Pro Phe Ser  Pro Asp Ala Ser Ser  Pro Leu Leu 
    1910                 1915                 1920             


Pro Met  Pro Ala Glu Phe Phe  His Pro Ala Val Ser  Ala Ser Gln 
    1925                 1930                 1935             


Lys Gly  Pro Glu Lys Gly Xaa  Gly Xaa Gly Xaa Leu  Pro Lys Ile 
    1940                 1945                 1950             


Ala Leu  Gln Gly Ser Trp Ala  Ser Leu Arg Ser Pro  Arg Val Asn 
    1955                 1960                 1965             


Cys Xaa  Leu Leu Arg Gln Ala  Xaa Gly Ser Asp Xaa  Ser Leu Asp 
    1970                 1975                 1980             


Ala Ser  Pro Ser Ser Ser Ala  Gly Ser Leu Gln Xaa  Xaa Leu Glu 
    1985                 1990                 1995             


Asp Ser  Leu Xaa Leu Ser Asp  Ser Pro Arg Arg Ala  Leu Gly Pro 
    2000                 2005                 2010             


Pro Ala  Pro Ala Pro Gly Pro  Arg Ala Gly Leu Ser  Pro Ala Ala 
    2015                 2020                 2025             


Arg Arg  Arg Leu Ser Leu Arg  Gly Arg Gly Leu Phe  Ser Leu Arg 
    2030                 2035                 2040             


Gly Leu  Arg Ala His Gln Arg  Ser His Ser Ser Gly  Gly Ser Xaa 
    2045                 2050                 2055             


Ser Pro  Gly Cys Xaa His His  Asp Ser Met Asp Pro  Ser Asp Glu 
    2060                 2065                 2070             


Glu Gly  Arg Gly Gly Ala Gly  Gly Gly Gly Ala Gly  Ser Glu His 
    2075                 2080                 2085             


Ser Glu  Xaa Leu Ser Ser Leu  Ser Leu Xaa Ser Leu  Phe Cys Pro 
    2090                 2095                 2100             


Pro Pro  Pro Pro Pro Ala Pro  Gly Leu Xaa Pro Ala  Arg Lys Phe 
    2105                 2110                 2115             


Ser Ser  Xaa Ser Ser Leu Ala  Ala Pro Gly Arg Pro  His Ala Ala 
    2120                 2125                 2130             


Ala Leu  Ala His Gly Leu Ala  Arg Ser Pro Ser Trp  Ala Ala Asp 
    2135                 2140                 2145             


Arg Ser  Lys Asp Pro Pro Gly  Arg Ala Pro Leu Pro  Met Gly Leu 
    2150                 2155                 2160             


Gly Pro  Leu Ala Pro Pro Pro  Gln Pro Leu Pro Gly  Glu Leu Glu 
    2165                 2170                 2175             


Pro Gly  Asp Ala Ala Ser Lys  Arg Lys Arg 
    2180                 2185             


<210> 4732
<211> 2223
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1107)..(1107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1298)..(1298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1340)..(1340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1344)..(1344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1476)..(1476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1485)..(1485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1494)..(1494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1503)..(1503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1517)..(1517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1527)..(1528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1567)..(1567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1603)..(1603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1611)..(1611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1660)..(1660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1670)..(1670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1676)..(1676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1687)..(1687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1692)..(1692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1716)..(1716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1766)..(1766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1785)..(1785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1819)..(1819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1853)..(1853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1878)..(1878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1912)..(1912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1980)..(1980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1982)..(1982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1984)..(1984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2005)..(2005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2011)..(2011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2015)..(2015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2030)..(2031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2037)..(2037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2093)..(2093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2098)..(2098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2126)..(2126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2133)..(2133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2148)..(2148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2156)..(2156)
<223> Selenocysteine

<400> 4732
Met Ala Glu Ser Ala Ser Pro Pro Ser Ser Ser Ala Ala Ala Pro Ala 
1               5                   10                  15      


Ala Glu Pro Gly Val Xaa Xaa Glu Gln Pro Gly Pro Arg Ser Pro Pro 
            20                  25                  30          


Ser Ser Pro Pro Gly Leu Glu Glu Pro Leu Asp Gly Ala Asp Pro His 
        35                  40                  45              


Val Pro His Pro Asp Leu Ala Pro Ile Ala Phe Phe Cys Leu Arg Gln 
    50                  55                  60                  


Xaa Xaa Ser Pro Arg Asn Trp Cys Ile Lys Met Val Cys Asn Pro Trp 
65                  70                  75                  80  


Phe Glu Cys Val Ser Met Leu Val Ile Leu Leu Asn Cys Val Xaa Leu 
                85                  90                  95      


Gly Met Tyr Gln Pro Cys Asp Asp Met Asp Cys Leu Ser Asp Arg Cys 
            100                 105                 110         


Lys Ile Leu Gln Val Phe Asp Asp Phe Ile Phe Ile Phe Phe Ala Met 
        115                 120                 125             


Glu Met Val Leu Lys Met Val Ala Leu Gly Ile Phe Gly Lys Lys Cys 
    130                 135                 140                 


Tyr Leu Gly Asp Xaa Trp Asn Arg Leu Asp Phe Phe Ile Val Met Ala 
145                 150                 155                 160 


Gly Met Val Glu Tyr Ser Leu Asp Leu Gln Asn Ile Asn Leu Ser Ala 
                165                 170                 175     


Ile Arg Xaa Val Arg Val Leu Arg Pro Leu Lys Ala Ile Asn Arg Val 
            180                 185                 190         


Pro Ser Met Arg Ile Leu Val Asn Leu Leu Leu Asp Xaa Leu Pro Met 
        195                 200                 205             


Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile Phe Gly 
    210                 215                 220                 


Ile Ile Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg Cys Phe 
225                 230                 235                 240 


Leu Glu Glu Asn Phe Xaa Ile Gln Gly Asp Val Ala Leu Pro Pro Tyr 
                245                 250                 255     


Tyr Gln Pro Glu Glu Asp Asp Glu Met Pro Phe Ile Cys Ser Leu Ser 
            260                 265                 270         


Gly Asp Asn Gly Ile Met Gly Cys His Glu Ile Pro Pro Leu Lys Glu 
        275                 280                 285             


Gln Gly Arg Glu Cys Cys Leu Ser Lys Asp Asp Val Tyr Asp Phe Gly 
    290                 295                 300                 


Ala Gly Arg Gln Asp Leu Asn Ala Ser Gly Leu Cys Val Asn Trp Asn 
305                 310                 315                 320 


Arg Tyr Tyr Asn Val Cys Arg Xaa Gly Ser Ala Asn Pro His Lys Gly 
                325                 330                 335     


Ala Ile Asn Phe Asp Asn Ile Gly Tyr Ala Trp Ile Val Ile Phe Gln 
            340                 345                 350         


Val Ile Xaa Leu Glu Gly Trp Val Glu Ile Met Tyr Tyr Val Met Asp 
        355                 360                 365             


Ala His Ser Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val 
    370                 375                 380                 


Gly Ser Phe Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Xaa Gln 
385                 390                 395                 400 


Phe Ser Glu Xaa Lys Gln Arg Glu His Arg Leu Met Leu Glu Gln Arg 
                405                 410                 415     


Gln Arg Tyr Leu Ser Ser Ser Xaa Val Ala Ser Tyr Ala Glu Pro Gly 
            420                 425                 430         


Asp Cys Tyr Glu Glu Ile Phe Gln Tyr Val Cys His Ile Leu Arg Lys 
        435                 440                 445             


Ala Lys Arg Arg Ala Leu Gly Leu Tyr Gln Ala Leu Gln Ser Arg Arg 
    450                 455                 460                 


Gln Ala Leu Gly Pro Glu Ala Pro Ala Pro Ala Lys Pro Gly Pro His 
465                 470                 475                 480 


Ala Lys Glu Pro Arg His Tyr His Gly Lys Xaa Lys Gly Gln Gly Asp 
                485                 490                 495     


Glu Gly Arg His Leu Gly Ser Arg His Cys Gln Xaa Leu His Gly Pro 
            500                 505                 510         


Ala Ser Pro Gly Asn Asp His Ser Gly Arg Glu Leu Cys Pro Gln His 
        515                 520                 525             


Ser Pro Leu Asp Ala Xaa Pro His Xaa Leu Val Gln Pro Ile Pro Ala 
    530                 535                 540                 


Xaa Leu Ala Ser Asp Pro Ala Ser Cys Pro Cys Cys Gln His Glu Asp 
545                 550                 555                 560 


Gly Arg Arg Pro Ser Gly Leu Gly Ser Xaa Asp Ser Gly Gln Glu Gly 
                565                 570                 575     


Ser Gly Ser Gly Ser Ser Ala Gly Gly Glu Asp Glu Ala Asp Gly Asp 
            580                 585                 590         


Gly Ala Arg Ser Ser Glu Asp Gly Ala Ser Ser Glu Leu Gly Lys Glu 
        595                 600                 605             


Glu Glu Glu Glu Glu Gln Ala Asp Gly Ala Val Trp Leu Cys Gly Asp 
    610                 615                 620                 


Val Trp Arg Glu Xaa Arg Ala Lys Leu Arg Gly Ile Val Asp Ser Lys 
625                 630                 635                 640 


Tyr Phe Asn Arg Gly Ile Met Met Ala Ile Leu Val Asn Xaa Val Ser 
                645                 650                 655     


Met Gly Ile Glu His His Glu Gln Pro Glu Glu Leu Xaa Asn Ile Leu 
            660                 665                 670         


Glu Ile Cys Asn Val Val Phe Xaa Ser Met Phe Ala Leu Glu Met Ile 
        675                 680                 685             


Leu Lys Leu Ala Ala Phe Gly Leu Phe Asp Tyr Leu Arg Asn Pro Tyr 
    690                 695                 700                 


Asn Ile Phe Asp Ser Ile Ile Val Ile Ile Ser Ile Trp Glu Ile Val 
705                 710                 715                 720 


Gly Gln Ala Asp Gly Gly Leu Ser Val Leu Arg Xaa Phe Arg Leu Leu 
                725                 730                 735     


Arg Val Leu Lys Leu Val Arg Phe Met Pro Ala Leu Arg Arg Gln Leu 
            740                 745                 750         


Val Val Leu Met Lys Xaa Met Asp Asn Val Ala Xaa Phe Cys Met Leu 
        755                 760                 765             


Leu Met Leu Phe Ile Phe Ile Phe Ser Ile Leu Gly Met His Ile Phe 
    770                 775                 780                 


Gly Cys Lys Phe Ser Leu Arg Xaa Asp Xaa Gly Asp Xaa Val Pro Asp 
785                 790                 795                 800 


Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala Ile Val Xaa Val Phe Gln 
                805                 810                 815     


Ile Leu Xaa Gln Glu Asp Trp Asn Val Val Leu Tyr Asn Gly Met Ala 
            820                 825                 830         


Ser Xaa Ser Pro Trp Ala Ser Leu Tyr Phe Val Ala Leu Met Xaa Phe 
        835                 840                 845             


Gly Asn Tyr Val Leu Phe Asn Leu Leu Val Ala Ile Leu Val Glu Gly 
    850                 855                 860                 


Phe Gln Ala Glu Gly Asp Ala Asn Arg Ser Tyr Ser Asp Glu Asp Gln 
865                 870                 875                 880 


Ser Ser Ser Asn Ile Glu Glu Phe Asp Lys Leu Gln Glu Gly Leu Asp 
                885                 890                 895     


Ser Ser Gly Asp Pro Lys Leu Cys Pro Ile Pro Met Xaa Pro Asn Gly 
            900                 905                 910         


His Leu Asp Pro Ser Leu Pro Leu Gly Gly His Leu Gly Pro Ala Gly 
        915                 920                 925             


Ala Ala Gly Pro Ala Pro Arg Leu Ser Leu Gln Pro Asp Pro Met Leu 
    930                 935                 940                 


Val Ala Leu Gly Ser Arg Lys Ser Ser Val Met Ser Leu Gly Arg Met 
945                 950                 955                 960 


Ser Tyr Asp Gln Arg Ser Leu Ser Ser Ser Arg Ser Ser Tyr Tyr Gly 
                965                 970                 975     


Pro Trp Gly Arg Ser Ala Ala Trp Ala Ser Arg Arg Ser Ser Trp Asn 
            980                 985                 990         


Ser Leu Lys His Lys Pro Pro Ser  Ala Glu His Glu Ser  Leu Leu Ser 
        995                 1000                 1005             


Ala Glu  Arg Gly Gly Gly Ala  Arg Val Cys Glu Val  Ala Ala Asp 
    1010                 1015                 1020             


Glu Gly  Pro Pro Arg Ala Ala  Pro Leu His Xaa Pro  His Ala His 
    1025                 1030                 1035             


His Ile  His His Gly Pro His  Leu Ala His Arg His  Arg His His 
    1040                 1045                 1050             


Arg Arg  Xaa Leu Ser Leu Asp  Asn Arg Asp Ser Val  Asp Leu Ala 
    1055                 1060                 1065             


Glu Leu  Val Pro Ala Val Gly  Ala His Pro Arg Ala  Ala Trp Arg 
    1070                 1075                 1080             


Ala Ala  Gly Pro Ala Pro Gly  His Glu Asp Cys Asn  Gly Arg Met 
    1085                 1090                 1095             


Pro Ser  Ile Ala Lys Asp Val  Phe Xaa Lys Met Gly  Asp Arg Gly 
    1100                 1105                 1110             


Asp Arg  Gly Glu Asp Glu Glu  Glu Ile Asp Tyr Xaa  Leu Cys Phe 
    1115                 1120                 1125             


Arg Val  Arg Lys Met Ile Asp  Val Tyr Lys Pro Asp  Trp Cys Glu 
    1130                 1135                 1140             


Val Arg  Glu Asp Trp Ser Val  Tyr Leu Phe Ser Pro  Glu Asn Arg 
    1145                 1150                 1155             


Phe Arg  Val Leu Cys Gln Xaa  Ile Ile Ala His Lys  Leu Phe Asp 
    1160                 1165                 1170             


Tyr Val  Val Leu Ala Phe Ile  Phe Leu Asn Cys Ile  Xaa Ile Ala 
    1175                 1180                 1185             


Leu Glu  Arg Pro Gln Ile Glu  Ala Gly Ser Xaa Glu  Arg Ile Phe 
    1190                 1195                 1200             


Leu Xaa  Val Ser Asn Tyr Ile  Phe Xaa Ala Ile Phe  Val Gly Glu 
    1205                 1210                 1215             


Met Xaa  Leu Lys Val Val Ser  Leu Gly Leu Tyr Phe  Gly Glu Gln 
    1220                 1225                 1230             


Ala Tyr  Leu Arg Ser Ser Trp  Asn Val Leu Asp Gly  Phe Leu Val 
    1235                 1240                 1245             


Phe Val  Ser Ile Ile Asp Ile  Val Val Ser Leu Ala  Ser Ala Gly 
    1250                 1255                 1260             


Gly Ala  Lys Ile Leu Gly Val  Leu Arg Val Leu Arg  Leu Leu Arg 
    1265                 1270                 1275             


Xaa Leu  Arg Pro Leu Arg Val  Ile Ser Arg Ala Pro  Gly Leu Lys 
    1280                 1285                 1290             


Leu Val  Val Glu Xaa Leu Ile  Ser Ser Leu Lys Pro  Ile Gly Asn 
    1295                 1300                 1305             


Ile Val  Leu Ile Cys Cys Ala  Phe Phe Ile Ile Phe  Gly Ile Leu 
    1310                 1315                 1320             


Gly Val  Gln Leu Phe Lys Gly  Lys Phe Tyr His Cys  Leu Gly Val 
    1325                 1330                 1335             


Asp Xaa  Arg Asn Ile Xaa Asn  Arg Ser Asp Cys Met  Ala Ala Asn 
    1340                 1345                 1350             


Tyr Arg  Trp Val His His Lys  Tyr Asn Phe Asp Asn  Leu Gly Gln 
    1355                 1360                 1365             


Ala Leu  Met Ser Leu Phe Val  Leu Ala Ser Lys Asp  Gly Trp Val 
    1370                 1375                 1380             


Asn Ile  Met Tyr Asn Gly Leu  Asp Ala Val Ala Val  Asp Gln Gln 
    1385                 1390                 1395             


Pro Val  Xaa Asn His Asn Pro  Trp Met Leu Leu Tyr  Phe Ile Ser 
    1400                 1405                 1410             


Phe Leu  Leu Ile Val Ser Phe  Phe Val Leu Asn Met  Phe Val Gly 
    1415                 1420                 1425             


Val Val  Val Glu Asn Phe His  Lys Cys Arg Gln His  Gln Glu Ala 
    1430                 1435                 1440             


Glu Glu  Ala Arg Arg Arg Glu  Glu Lys Arg Leu Arg  Arg Leu Glu 
    1445                 1450                 1455             


Lys Lys  Arg Arg Lys Ala Gln  Arg Leu Pro Tyr Tyr  Ala Xaa Tyr 
    1460                 1465                 1470             


Cys His  Xaa Arg Leu Leu Ile  His Ser Met Cys Xaa  Ser His Tyr 
    1475                 1480                 1485             


Leu Asp  Ile Phe Ile Xaa Phe  Ile Ile Cys Leu Asn  Val Val Xaa 
    1490                 1495                 1500             


Met Ser  Leu Glu His Tyr Asn  Gln Pro Xaa Ser Leu  Glu Xaa Ala 
    1505                 1510                 1515             


Leu Lys  Tyr Cys Asn Tyr Met  Phe Xaa Xaa Val Phe  Val Leu Glu 
    1520                 1525                 1530             


Ala Val  Leu Lys Leu Val Ala  Phe Gly Leu Arg Arg  Phe Phe Lys 
    1535                 1540                 1545             


Asp Arg  Trp Asn Gln Leu Asp  Leu Ala Ile Val Leu  Leu Ser Val 
    1550                 1555                 1560             


Met Gly  Ile Xaa Leu Glu Glu  Ile Glu Ile Asn Ala  Ala Leu Pro 
    1565                 1570                 1575             


Ile Asn  Pro Xaa Ile Ile Arg  Ile Met Arg Val Leu  Arg Ile Ala 
    1580                 1585                 1590             


Arg Val  Leu Lys Leu Leu Lys  Met Ala Xaa Gly Met  Arg Ala Leu 
    1595                 1600                 1605             


Leu Asp  Xaa Val Val Gln Ala  Leu Pro Gln Val Gly  Asn Leu Gly 
    1610                 1615                 1620             


Leu Leu  Phe Met Leu Leu Phe  Phe Ile Tyr Ala Ala  Leu Gly Val 
    1625                 1630                 1635             


Glu Leu  Phe Gly Lys Leu Val  Cys Asn Asp Glu Asn  Pro Cys Glu 
    1640                 1645                 1650             


Gly Met  Ser Arg His Ala Xaa  Phe Glu Asn Phe Gly  Met Ala Phe 
    1655                 1660                 1665             


Leu Xaa  Leu Phe Gln Val Ser  Xaa Gly Asp Asn Trp  Asn Gly Ile 
    1670                 1675                 1680             


Met Lys  Asp Xaa Leu Arg Asp  Cys Xaa His Asp Glu  Arg Ser Cys 
    1685                 1690                 1695             


Leu Ser  Ser Leu Gln Phe Val  Ser Pro Leu Tyr Phe  Val Ser Phe 
    1700                 1705                 1710             


Val Leu  Xaa Ala Gln Phe Val  Leu Ile Asn Val Val  Val Ala Val 
    1715                 1720                 1725             


Leu Met  Lys His Leu Asp Asp  Ser Asn Lys Glu Ala  Gln Glu Asp 
    1730                 1735                 1740             


Ala Glu  Met Asp Ala Glu Leu  Glu Leu Glu Met Ala  His Gly Leu 
    1745                 1750                 1755             


Gly Pro  Gly Pro Arg Leu Pro  Xaa Gly Ser Pro Gly  Ala Pro Gly 
    1760                 1765                 1770             


Arg Gly  Pro Gly Gly Ala Gly  Gly Gly Gly Asp Xaa  Glu Gly Gly 
    1775                 1780                 1785             


Leu Cys  Arg Arg Cys Tyr Ser  Pro Ala Gln Glu Asn  Leu Trp Leu 
    1790                 1795                 1800             


Asp Ser  Val Ser Leu Ile Ile  Lys Asp Ser Leu Glu  Gly Glu Leu 
    1805                 1810                 1815             


Xaa Ile  Ile Asp Asn Leu Ser  Gly Ser Ile Phe His  His Tyr Ser 
    1820                 1825                 1830             


Ser Pro  Ala Gly Cys Lys Lys  Cys His His Asp Lys  Gln Glu Val 
    1835                 1840                 1845             


Gln Leu  Ala Glu Xaa Glu Ala  Phe Ser Leu Asn Ser  Asp Arg Ser 
    1850                 1855                 1860             


Ser Ser  Ile Leu Leu Gly Asp  Asp Leu Ser Leu Glu  Asp Pro Xaa 
    1865                 1870                 1875             


Ala Cys  Pro Pro Gly Arg Lys  Asp Ser Lys Gly Glu  Leu Asp Pro 
    1880                 1885                 1890             


Pro Glu  Pro Met Arg Val Gly  Asp Leu Gly Glu Cys  Phe Phe Pro 
    1895                 1900                 1905             


Leu Ser  Ser Xaa Ala Val Ser  Pro Asp Pro Glu Asn  Phe Leu Cys 
    1910                 1915                 1920             


Glu Met  Glu Glu Ile Pro Phe  Asn Pro Val Arg Ser  Trp Leu Lys 
    1925                 1930                 1935             


His Asp  Ser Ser Gln Ala Pro  Pro Ser Pro Phe Ser  Pro Asp Ala 
    1940                 1945                 1950             


Ser Ser  Pro Leu Leu Pro Met  Pro Ala Glu Phe Phe  His Pro Ala 
    1955                 1960                 1965             


Val Ser  Ala Ser Gln Lys Gly  Pro Glu Lys Gly Xaa  Gly Xaa Gly 
    1970                 1975                 1980             


Xaa Leu  Pro Lys Ile Ala Leu  Gln Gly Ser Trp Ala  Ser Leu Arg 
    1985                 1990                 1995             


Ser Pro  Arg Val Asn Cys Xaa  Leu Leu Arg Gln Ala  Xaa Gly Ser 
    2000                 2005                 2010             


Asp Xaa  Ser Leu Asp Ala Ser  Pro Ser Ser Ser Ala  Gly Ser Leu 
    2015                 2020                 2025             


Gln Xaa  Xaa Leu Glu Asp Ser  Leu Xaa Leu Ser Asp  Ser Pro Arg 
    2030                 2035                 2040             


Arg Ala  Leu Gly Pro Pro Ala  Pro Ala Pro Gly Pro  Arg Ala Gly 
    2045                 2050                 2055             


Leu Ser  Pro Ala Ala Arg Arg  Arg Leu Ser Leu Arg  Gly Arg Gly 
    2060                 2065                 2070             


Leu Phe  Ser Leu Arg Gly Leu  Arg Ala His Gln Arg  Ser His Ser 
    2075                 2080                 2085             


Ser Gly  Gly Ser Xaa Ser Pro  Gly Cys Xaa His His  Asp Ser Met 
    2090                 2095                 2100             


Asp Pro  Ser Asp Glu Glu Gly  Arg Gly Gly Ala Gly  Gly Gly Gly 
    2105                 2110                 2115             


Ala Gly  Ser Glu His Ser Glu  Xaa Leu Ser Ser Leu  Ser Leu Xaa 
    2120                 2125                 2130             


Ser Leu  Phe Cys Pro Pro Pro  Pro Pro Pro Ala Pro  Gly Leu Xaa 
    2135                 2140                 2145             


Pro Ala  Arg Lys Phe Ser Ser  Xaa Ser Ser Leu Ala  Ala Pro Gly 
    2150                 2155                 2160             


Arg Pro  His Ala Ala Ala Leu  Ala His Gly Leu Ala  Arg Ser Pro 
    2165                 2170                 2175             


Ser Trp  Ala Ala Asp Arg Ser  Lys Asp Pro Pro Gly  Arg Ala Pro 
    2180                 2185                 2190             


Leu Pro  Met Gly Leu Gly Pro  Leu Ala Pro Pro Pro  Gln Pro Leu 
    2195                 2200                 2205             


Pro Gly  Glu Leu Glu Pro Gly  Asp Ala Ala Ser Lys  Arg Lys Arg 
    2210                 2215                 2220             


<210> 4733
<211> 471
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<400> 4733
Met Glu Gly Ser Ala Asp Ser Tyr Xaa Ser Arg Pro Ser Leu Asp Ser 
1               5                   10                  15      


Asp Val Ser Leu Glu Glu Asp Arg Glu Ser Ala Arg Arg Glu Val Glu 
            20                  25                  30          


Ser Gln Ala Gln Gln Gln Leu Glu Arg Ala Lys His Lys Pro Val Ala 
        35                  40                  45              


Phe Ala Val Arg Xaa Asn Val Ser Tyr Cys Gly Val Leu Asp Glu Glu 
    50                  55                  60                  


Cys Pro Val Gln Gly Ser Gly Val Asn Phe Glu Ala Lys Asp Phe Leu 
65                  70                  75                  80  


His Ile Lys Glu Lys Tyr Ser Asn Asp Trp Trp Ile Gly Arg Leu Val 
                85                  90                  95      


Lys Glu Gly Gly Asp Ile Ala Phe Ile Pro Ser Pro Gln Arg Leu Glu 
            100                 105                 110         


Ser Ile Arg Leu Lys Gln Glu Gln Lys Ala Arg Arg Ser Gly Asn Pro 
        115                 120                 125             


Ser Ser Leu Ser Asp Ile Gly Asn Arg Arg Ser Pro Pro Pro Ser Leu 
    130                 135                 140                 


Ala Lys Gln Lys Gln Lys Gln Ala Glu His Val Pro Pro Tyr Asp Val 
145                 150                 155                 160 


Val Pro Ser Met Arg Pro Val Val Leu Val Gly Pro Ser Leu Lys Gly 
                165                 170                 175     


Tyr Glu Val Xaa Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys 
            180                 185                 190         


His Arg Phe Asp Gly Arg Ile Ser Ile Xaa Arg Val Xaa Ala Asp Leu 
        195                 200                 205             


Ser Leu Ala Lys Arg Ser Val Leu Asn Asn Pro Gly Lys Arg Xaa Ile 
    210                 215                 220                 


Ile Glu Arg Ser Ser Ala Arg Ser Ser Ile Ala Glu Val Gln Ser Glu 
225                 230                 235                 240 


Ile Glu Arg Ile Phe Glu Leu Ala Lys Ser Leu Gln Leu Val Val Leu 
                245                 250                 255     


Asp Ala Asp Xaa Ile Asn His Pro Ala Gln Leu Ala Lys Xaa Ser Leu 
            260                 265                 270         


Ala Pro Ile Ile Val Phe Val Lys Val Ser Ser Pro Lys Val Leu Gln 
        275                 280                 285             


Arg Leu Ile Arg Ser Arg Gly Lys Ser Gln Met Lys His Leu Xaa Val 
    290                 295                 300                 


Gln Met Met Ala Tyr Asp Lys Leu Val Gln Cys Pro Pro Glu Ser Phe 
305                 310                 315                 320 


Asp Val Ile Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu 
                325                 330                 335     


Ala Glu Tyr Leu Glu Val Tyr Trp Arg Ala Xaa His His Pro Ala Pro 
            340                 345                 350         


Gly Pro Gly Leu Leu Gly Pro Pro Ser Ala Ile Pro Gly Leu Gln Asn 
        355                 360                 365             


Gln Gln Leu Leu Gly Glu Arg Gly Glu Glu His Ser Pro Leu Glu Arg 
    370                 375                 380                 


Asp Ser Leu Met Pro Ser Asp Glu Ala Ser Glu Ser Ser Arg Gln Ala 
385                 390                 395                 400 


Trp Xaa Gly Ser Ser Gln Arg Ser Ser Arg His Leu Glu Glu Asp Tyr 
                405                 410                 415     


Ala Asp Ala Tyr Gln Asp Leu Tyr Gln Pro His Arg Gln His Xaa Ser 
            420                 425                 430         


Gly Leu Pro Ser Ala Asn Gly His Asp Pro Gln Asp Arg Leu Leu Ala 
        435                 440                 445             


Gln Asp Ser Glu His Asn His Ser Asp Arg Asn Trp Gln Arg Asn Arg 
    450                 455                 460                 


Pro Trp Pro Lys Asp Ser Tyr 
465                 470     


<210> 4734
<211> 151
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<400> 4734
Met Glu Gly Ser Ala Asp Ser Tyr Xaa Ser Arg Pro Ser Leu Asp Ser 
1               5                   10                  15      


Asp Val Ser Leu Glu Glu Asp Arg Glu Ser Ala Arg Arg Glu Val Glu 
            20                  25                  30          


Ser Gln Ala Gln Gln Gln Leu Glu Arg Ala Lys His Lys Pro Val Ala 
        35                  40                  45              


Phe Ala Val Arg Xaa Asn Val Ser Tyr Cys Gly Val Leu Asp Glu Glu 
    50                  55                  60                  


Cys Pro Val Gln Gly Ser Gly Val Asn Phe Glu Ala Lys Asp Phe Leu 
65                  70                  75                  80  


His Ile Lys Glu Lys Tyr Ser Asn Asp Trp Trp Ile Gly Arg Leu Val 
                85                  90                  95      


Lys Glu Gly Gly Asp Ile Ala Phe Ile Pro Ser Pro Gln Arg Leu Glu 
            100                 105                 110         


Ser Ile Arg Leu Lys Gln Glu Gln Lys Ala Arg Arg Ser Gly Asn Pro 
        115                 120                 125             


Ser Ser Leu Ser Asp Ile Gly Asn Arg Arg Ser Pro Pro Pro Ser Leu 
    130                 135                 140                 


Gly Gly Xaa Cys Ser Pro Ile 
145                 150     


<210> 4735
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<400> 4735
Met Arg Pro Val Val Leu Val Gly Pro Ser Leu Lys Gly Tyr Glu Val 
1               5                   10                  15      


Xaa Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His Arg Phe 
            20                  25                  30          


Asp Gly Arg Ile Ser Ile Xaa Arg Val Xaa Ala Asp Leu Ser Leu Ala 
        35                  40                  45              


Lys Arg Ser Val Leu Asn Asn 
    50                  55  


<210> 4736
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<400> 4736
Met Arg Pro Val Val Leu Val Gly Pro Ser Leu Lys Gly Tyr Glu Val 
1               5                   10                  15      


Xaa Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His Arg Phe 
            20                  25                  30          


Asp Gly Arg Ile Ser Ile Xaa Arg Val Xaa Ala Asp Leu Ser Leu Ala 
        35                  40                  45              


Lys Arg Ser Val Leu Asn Asn Pro Gly Lys Arg Xaa Ile Ile Glu Arg 
    50                  55                  60                  


Ser Ser Ala Arg Ser Ser Ile Ala Glu Val Gln Ser Glu Ile Glu Arg 
65                  70                  75                  80  


Ile Phe Glu Leu Ala Lys Ser Leu Gln Leu Val Val Leu Asp Ala Asp 
                85                  90                  95      


Xaa Ile Asn His Pro Ala Gln Leu Ala Lys Xaa Ser Leu Ala Pro Ile 
            100                 105                 110         


Ile Val Phe Val Lys Val Ser Ser Pro Lys 
        115                 120         


<210> 4737
<211> 105
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<400> 4737
Met Ser Phe Ser Asp Ser Ser Ala Xaa Phe Leu Leu Asn Glu Gly Ser 
1               5                   10                  15      


Ala Asp Ser Tyr Xaa Ser Arg Pro Ser Leu Asp Ser Asp Val Ser Leu 
            20                  25                  30          


Glu Glu Asp Arg Glu Ser Ala Arg Arg Glu Val Glu Ser Gln Ala Gln 
        35                  40                  45              


Gln Gln Leu Glu Arg Ala Lys His Lys Pro Val Ala Phe Ala Val Arg 
    50                  55                  60                  


Xaa Asn Val Ser Tyr Cys Gly Val Leu Asp Glu Glu Cys Pro Val Gln 
65                  70                  75                  80  


Gly Ser Gly Val Asn Phe Glu Ala Lys Asp Phe Leu His Ile Lys Glu 
                85                  90                  95      


Glu Ile Trp Glu Pro Phe Gln Pro Glu 
            100                 105 


<210> 4738
<211> 483
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<400> 4738
Met Ser Phe Ser Asp Ser Ser Ala Xaa Phe Leu Leu Asn Glu Gly Ser 
1               5                   10                  15      


Ala Asp Ser Tyr Xaa Ser Arg Pro Ser Leu Asp Ser Asp Val Ser Leu 
            20                  25                  30          


Glu Glu Asp Arg Glu Ser Ala Arg Arg Glu Val Glu Ser Gln Ala Gln 
        35                  40                  45              


Gln Gln Leu Glu Arg Ala Lys His Lys Pro Val Ala Phe Ala Val Arg 
    50                  55                  60                  


Xaa Asn Val Ser Tyr Cys Gly Val Leu Asp Glu Glu Cys Pro Val Gln 
65                  70                  75                  80  


Gly Ser Gly Val Asn Phe Glu Ala Lys Asp Phe Leu His Ile Lys Glu 
                85                  90                  95      


Lys Tyr Ser Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly Gly 
            100                 105                 110         


Asp Ile Ala Phe Ile Pro Ser Pro Gln Arg Leu Glu Ser Ile Arg Leu 
        115                 120                 125             


Lys Gln Glu Gln Lys Ala Arg Arg Ser Gly Asn Pro Ser Ser Leu Ser 
    130                 135                 140                 


Asp Ile Gly Asn Arg Arg Ser Pro Pro Pro Ser Leu Ala Lys Gln Lys 
145                 150                 155                 160 


Gln Lys Gln Ala Glu His Val Pro Pro Tyr Asp Val Val Pro Ser Met 
                165                 170                 175     


Arg Pro Val Val Leu Val Gly Pro Ser Leu Lys Gly Tyr Glu Val Xaa 
            180                 185                 190         


Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His Arg Phe Asp 
        195                 200                 205             


Gly Arg Ile Ser Ile Xaa Arg Val Xaa Ala Asp Leu Ser Leu Ala Lys 
    210                 215                 220                 


Arg Ser Val Leu Asn Asn Pro Gly Lys Arg Xaa Ile Ile Glu Arg Ser 
225                 230                 235                 240 


Ser Ala Arg Ser Ser Ile Ala Glu Val Gln Ser Glu Ile Glu Arg Ile 
                245                 250                 255     


Phe Glu Leu Ala Lys Ser Leu Gln Leu Val Val Leu Asp Ala Asp Xaa 
            260                 265                 270         


Ile Asn His Pro Ala Gln Leu Ala Lys Xaa Ser Leu Ala Pro Ile Ile 
        275                 280                 285             


Val Phe Val Lys Val Ser Ser Pro Lys Val Leu Gln Arg Leu Ile Arg 
    290                 295                 300                 


Ser Arg Gly Lys Ser Gln Met Lys His Leu Xaa Val Gln Met Met Ala 
305                 310                 315                 320 


Tyr Asp Lys Leu Val Gln Cys Pro Pro Glu Ser Phe Asp Val Ile Leu 
                325                 330                 335     


Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu Ala Glu Tyr Leu 
            340                 345                 350         


Glu Val Tyr Trp Arg Ala Xaa His His Pro Ala Pro Gly Pro Gly Leu 
        355                 360                 365             


Leu Gly Pro Pro Ser Ala Ile Pro Gly Leu Gln Asn Gln Gln Leu Leu 
    370                 375                 380                 


Gly Glu Arg Gly Glu Glu His Ser Pro Leu Glu Arg Asp Ser Leu Met 
385                 390                 395                 400 


Pro Ser Asp Glu Ala Ser Glu Ser Ser Arg Gln Ala Trp Xaa Gly Ser 
                405                 410                 415     


Ser Gln Arg Ser Ser Arg His Leu Glu Glu Asp Tyr Ala Asp Ala Tyr 
            420                 425                 430         


Gln Asp Leu Tyr Gln Pro His Arg Gln His Xaa Ser Gly Leu Pro Ser 
        435                 440                 445             


Ala Asn Gly His Asp Pro Gln Asp Arg Leu Leu Ala Gln Asp Ser Glu 
    450                 455                 460                 


His Asn His Ser Asp Arg Asn Trp Gln Arg Asn Arg Pro Trp Pro Lys 
465                 470                 475                 480 


Asp Ser Tyr 
            


<210> 4739
<211> 484
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<400> 4739
Met Tyr Asp Asp Ser Tyr Val Pro Gly Phe Glu Asp Ser Glu Ala Gly 
1               5                   10                  15      


Ser Ala Asp Ser Tyr Xaa Ser Arg Pro Ser Leu Asp Ser Asp Val Ser 
            20                  25                  30          


Leu Glu Glu Asp Arg Glu Ser Ala Arg Arg Glu Val Glu Ser Gln Ala 
        35                  40                  45              


Gln Gln Gln Leu Glu Arg Ala Lys His Lys Pro Val Ala Phe Ala Val 
    50                  55                  60                  


Arg Xaa Asn Val Ser Tyr Cys Gly Val Leu Asp Glu Glu Cys Pro Val 
65                  70                  75                  80  


Gln Gly Ser Gly Val Asn Phe Glu Ala Lys Asp Phe Leu His Ile Lys 
                85                  90                  95      


Glu Lys Tyr Ser Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly 
            100                 105                 110         


Gly Asp Ile Ala Phe Ile Pro Ser Pro Gln Arg Leu Glu Ser Ile Arg 
        115                 120                 125             


Leu Lys Gln Glu Gln Lys Ala Arg Arg Ser Gly Asn Pro Ser Ser Leu 
    130                 135                 140                 


Ser Asp Ile Gly Asn Arg Arg Ser Pro Pro Pro Ser Leu Ala Lys Gln 
145                 150                 155                 160 


Lys Gln Lys Gln Ala Glu His Val Pro Pro Tyr Asp Val Val Pro Ser 
                165                 170                 175     


Met Arg Pro Val Val Leu Val Gly Pro Ser Leu Lys Gly Tyr Glu Val 
            180                 185                 190         


Xaa Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His Arg Phe 
        195                 200                 205             


Asp Gly Arg Ile Ser Ile Xaa Arg Val Xaa Ala Asp Leu Ser Leu Ala 
    210                 215                 220                 


Lys Arg Ser Val Leu Asn Asn Pro Gly Lys Arg Xaa Ile Ile Glu Arg 
225                 230                 235                 240 


Ser Ser Ala Arg Ser Ser Ile Ala Glu Val Gln Ser Glu Ile Glu Arg 
                245                 250                 255     


Ile Phe Glu Leu Ala Lys Ser Leu Gln Leu Val Val Leu Asp Ala Asp 
            260                 265                 270         


Xaa Ile Asn His Pro Ala Gln Leu Ala Lys Xaa Ser Leu Ala Pro Ile 
        275                 280                 285             


Ile Val Phe Val Lys Val Ser Ser Pro Lys Val Leu Gln Arg Leu Ile 
    290                 295                 300                 


Arg Ser Arg Gly Lys Ser Gln Met Lys His Leu Xaa Val Gln Met Met 
305                 310                 315                 320 


Ala Tyr Asp Lys Leu Val Gln Cys Pro Pro Glu Ser Phe Asp Val Ile 
                325                 330                 335     


Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu Ala Glu Tyr 
            340                 345                 350         


Leu Glu Val Tyr Trp Arg Ala Xaa His His Pro Ala Pro Gly Pro Gly 
        355                 360                 365             


Leu Leu Gly Pro Pro Ser Ala Ile Pro Gly Leu Gln Asn Gln Gln Leu 
    370                 375                 380                 


Leu Gly Glu Arg Gly Glu Glu His Ser Pro Leu Glu Arg Asp Ser Leu 
385                 390                 395                 400 


Met Pro Ser Asp Glu Ala Ser Glu Ser Ser Arg Gln Ala Trp Xaa Gly 
                405                 410                 415     


Ser Ser Gln Arg Ser Ser Arg His Leu Glu Glu Asp Tyr Ala Asp Ala 
            420                 425                 430         


Tyr Gln Asp Leu Tyr Gln Pro His Arg Gln His Xaa Ser Gly Leu Pro 
        435                 440                 445             


Ser Ala Asn Gly His Asp Pro Gln Asp Arg Leu Leu Ala Gln Asp Ser 
    450                 455                 460                 


Glu His Asn His Ser Asp Arg Asn Trp Gln Arg Asn Arg Pro Trp Pro 
465                 470                 475                 480 


Lys Asp Ser Tyr 
                


<210> 4740
<211> 457
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<400> 4740
Met Tyr Asp Asp Ser Tyr Val Pro Gly Phe Glu Asp Ser Glu Ala Gly 
1               5                   10                  15      


Ser Ala Asp Ser Tyr Xaa Ser Arg Pro Ser Leu Asp Ser Asp Val Ser 
            20                  25                  30          


Leu Glu Glu Asp Arg Glu Ser Ala Arg Arg Glu Val Glu Ser Gln Ala 
        35                  40                  45              


Gln Gln Gln Leu Glu Arg Ala Lys His Lys Pro Val Ala Phe Ala Val 
    50                  55                  60                  


Arg Xaa Asn Val Ser Tyr Cys Gly Val Leu Asp Glu Glu Cys Pro Val 
65                  70                  75                  80  


Gln Gly Ser Gly Val Asn Phe Glu Ala Lys Asp Phe Leu His Ile Lys 
                85                  90                  95      


Glu Lys Tyr Ser Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly 
            100                 105                 110         


Gly Asp Ile Ala Phe Ile Pro Ser Pro Gln Arg Leu Glu Ser Ile Arg 
        115                 120                 125             


Leu Lys Gln Glu Gln Lys Ala Arg Arg Ser Gly Asn Pro Ser Ser Leu 
    130                 135                 140                 


Ser Asp Ile Gly Asn Arg Arg Ser Pro Pro Pro Ser Leu Ala Lys Gln 
145                 150                 155                 160 


Lys Gln Lys Gln Val Xaa Asp Met Met Gln Lys Ala Leu Phe Asp Phe 
                165                 170                 175     


Leu Lys His Arg Phe Asp Gly Arg Ile Ser Ile Xaa Arg Val Xaa Ala 
            180                 185                 190         


Asp Leu Ser Leu Ala Lys Arg Ser Val Leu Asn Asn Pro Gly Lys Arg 
        195                 200                 205             


Xaa Ile Ile Glu Arg Ser Ser Ala Arg Ser Ser Ile Ala Glu Val Gln 
    210                 215                 220                 


Ser Glu Ile Glu Arg Ile Phe Glu Leu Ala Lys Ser Leu Gln Leu Val 
225                 230                 235                 240 


Val Leu Asp Ala Asp Xaa Ile Asn His Pro Ala Gln Leu Ala Lys Xaa 
                245                 250                 255     


Ser Leu Ala Pro Ile Ile Val Phe Val Lys Val Ser Ser Pro Lys Val 
            260                 265                 270         


Leu Gln Arg Leu Ile Arg Ser Arg Gly Lys Ser Gln Met Lys His Leu 
        275                 280                 285             


Xaa Val Gln Met Met Ala Tyr Asp Lys Leu Val Gln Cys Pro Pro Glu 
    290                 295                 300                 


Ser Phe Asp Val Ile Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu 
305                 310                 315                 320 


His Leu Ala Glu Tyr Leu Glu Val Tyr Trp Arg Ala Xaa His His Pro 
                325                 330                 335     


Ala Pro Gly Pro Gly Leu Leu Gly Pro Pro Ser Ala Ile Pro Gly Leu 
            340                 345                 350         


Gln Asn Gln Gln Leu Leu Gly Glu Arg Gly Glu Glu His Ser Pro Leu 
        355                 360                 365             


Glu Arg Asp Ser Leu Met Pro Ser Asp Glu Ala Ser Glu Ser Ser Arg 
    370                 375                 380                 


Gln Ala Trp Xaa Gly Ser Ser Gln Arg Ser Ser Arg His Leu Glu Glu 
385                 390                 395                 400 


Asp Tyr Ala Asp Ala Tyr Gln Asp Leu Tyr Gln Pro His Arg Gln His 
                405                 410                 415     


Xaa Ser Gly Leu Pro Ser Ala Asn Gly His Asp Pro Gln Asp Arg Leu 
            420                 425                 430         


Leu Ala Gln Asp Ser Glu His Asn His Ser Asp Arg Asn Trp Gln Arg 
        435                 440                 445             


Asn Arg Pro Trp Pro Lys Asp Ser Tyr 
    450                 455         


<210> 4741
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 4741
Met Tyr Asp Asp Ser Tyr Val Pro Gly Phe Glu Asp Ser Glu Ala Gly 
1               5                   10                  15      


Ser Ala Asp Ser Tyr Xaa Ser Arg Pro Ser Leu Asp Ser Asp Val Ser 
            20                  25                  30          


Leu Glu Glu Asp Arg Glu Ser Ala Arg Arg Glu Val Glu Ser Gln Ala 
        35                  40                  45              


Gln Gln Gln Leu Glu Arg Ala Lys His Lys Pro Val Ala Phe Ala Val 
    50                  55                  60                  


Arg Xaa Asn Val Ser Tyr Cys Gly Val Leu Asp Glu Glu Cys Pro Val 
65                  70                  75                  80  


Gln Gly Ser Gly Val Asn Phe Glu Ala Lys Asp Phe Leu His Ile Lys 
                85                  90                  95      


Glu Tyr Ser Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly Gly 
            100                 105                 110         


Asp Ile Ala Phe Ile Pro Ser Pro Gln Arg Leu Glu Ser Ile Arg Leu 
        115                 120                 125             


Lys Gln Glu Gln Lys Ala Arg Arg Ser Gly Asn Pro Ser Ser Leu Ser 
    130                 135                 140                 


<210> 4742
<211> 443
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<400> 4742
Met Tyr Asp Asp Ser Tyr Val Pro Gly Phe Glu Asp Ser Glu Ala Gly 
1               5                   10                  15      


Ser Ala Asp Ser Tyr Xaa Ser Arg Pro Ser Leu Asp Ser Asp Val Ser 
            20                  25                  30          


Leu Glu Glu Asp Arg Glu Ser Ala Arg Arg Glu Val Glu Ser Gln Ala 
        35                  40                  45              


Gln Gln Gln Leu Glu Arg Ala Lys Lys Tyr Ser Asn Asp Trp Trp Ile 
    50                  55                  60                  


Gly Arg Leu Val Lys Glu Gly Gly Asp Ile Ala Phe Ile Pro Ser Pro 
65                  70                  75                  80  


Gln Arg Leu Glu Ser Ile Arg Leu Lys Gln Glu Gln Lys Ala Arg Arg 
                85                  90                  95      


Ser Gly Asn Pro Ser Ser Leu Ser Asp Ile Gly Asn Arg Arg Ser Pro 
            100                 105                 110         


Pro Pro Ser Leu Ala Lys Gln Lys Gln Lys Gln Ala Glu His Val Pro 
        115                 120                 125             


Pro Tyr Asp Val Val Pro Ser Met Arg Pro Val Val Leu Val Gly Pro 
    130                 135                 140                 


Ser Leu Lys Gly Tyr Glu Val Xaa Asp Met Met Gln Lys Ala Leu Phe 
145                 150                 155                 160 


Asp Phe Leu Lys His Arg Phe Asp Gly Arg Ile Ser Ile Xaa Arg Val 
                165                 170                 175     


Xaa Ala Asp Leu Ser Leu Ala Lys Arg Ser Val Leu Asn Asn Pro Gly 
            180                 185                 190         


Lys Arg Xaa Ile Ile Glu Arg Ser Ser Ala Arg Ser Ser Ile Ala Glu 
        195                 200                 205             


Val Gln Ser Glu Ile Glu Arg Ile Phe Glu Leu Ala Lys Ser Leu Gln 
    210                 215                 220                 


Leu Val Val Leu Asp Ala Asp Xaa Ile Asn His Pro Ala Gln Leu Ala 
225                 230                 235                 240 


Lys Xaa Ser Leu Ala Pro Ile Ile Val Phe Val Lys Val Ser Ser Pro 
                245                 250                 255     


Lys Val Leu Gln Arg Leu Ile Arg Ser Arg Gly Lys Ser Gln Met Lys 
            260                 265                 270         


His Leu Xaa Val Gln Met Met Ala Tyr Asp Lys Leu Val Gln Cys Pro 
        275                 280                 285             


Pro Glu Ser Phe Asp Val Ile Leu Asp Glu Asn Gln Leu Glu Asp Ala 
    290                 295                 300                 


Cys Glu His Leu Ala Glu Tyr Leu Glu Val Tyr Trp Arg Ala Xaa His 
305                 310                 315                 320 


His Pro Ala Pro Gly Pro Gly Leu Leu Gly Pro Pro Ser Ala Ile Pro 
                325                 330                 335     


Gly Leu Gln Asn Gln Gln Leu Leu Gly Glu Arg Gly Glu Glu His Ser 
            340                 345                 350         


Pro Leu Glu Arg Asp Ser Leu Met Pro Ser Asp Glu Ala Ser Glu Ser 
        355                 360                 365             


Ser Arg Gln Ala Trp Xaa Gly Ser Ser Gln Arg Ser Ser Arg His Leu 
    370                 375                 380                 


Glu Glu Asp Tyr Ala Asp Ala Tyr Gln Asp Leu Tyr Gln Pro His Arg 
385                 390                 395                 400 


Gln His Xaa Ser Gly Leu Pro Ser Ala Asn Gly His Asp Pro Gln Asp 
                405                 410                 415     


Arg Leu Leu Ala Gln Asp Ser Glu His Asn His Ser Asp Arg Asn Trp 
            420                 425                 430         


Gln Arg Asn Arg Pro Trp Pro Lys Asp Ser Tyr 
        435                 440             


<210> 4743
<211> 37
<212> PRT
<213> Homo sapiens

<400> 4743
Met Tyr Asp Asp Ser Tyr Val Pro Gly Phe Glu Asp Ser Glu Ala Pro 
1               5                   10                  15      


Pro Ala Glu Ala Ser Ser Ala Ala Gly Ile Leu Ser Ser Cys Pro Ala 
            20                  25                  30          


Trp Arg Ala Trp Arg 
        35          


<210> 4744
<211> 84
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<400> 4744
Gln Gln Leu Glu Arg Ala Lys His Lys Pro Val Ala Phe Ala Val Arg 
1               5                   10                  15      


Xaa Asn Val Ser Tyr Cys Gly Val Leu Asp Glu Glu Cys Pro Val Gln 
            20                  25                  30          


Gly Ser Gly Val Asn Phe Glu Ala Lys Asp Phe Leu His Ile Lys Glu 
        35                  40                  45              


Asn Leu Gly Gly Pro Pro Cys Leu Ser His Ser Phe Ala Leu His Pro 
    50                  55                  60                  


Val Ile Ser Val Leu Val Pro His Xaa Ser Leu Glu Asn Arg Ala Pro 
65                  70                  75                  80  


Asp Phe Val Pro 
                


<210> 4745
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<400> 4745
Xaa Lys Asp Phe Leu His Ile Lys Glu Lys Tyr Ser Asn Asp Trp Trp 
1               5                   10                  15      


Ile Gly Arg Leu Val Lys Glu Gly Gly Asp Ile Ala Phe Ile Pro Ser 
            20                  25                  30          


Pro Gln Arg Leu Glu Ser Ile Arg Leu Lys Gln Glu Gln Lys Ala Arg 
        35                  40                  45              


Arg Ser Gly Asn Pro Ser Ser Leu Ser Asp Ile Gly Asn Arg Arg Ser 
    50                  55                  60                  


Pro Pro Pro Ser Leu Gly Gly Xaa Cys Ser Pro Ile 
65                  70                  75      


<210> 4746
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 4746
Asp Leu Ala Val Glu Met His Glu Pro Tyr Xaa Phe Leu Asn Gly Leu 
1               5                   10                  15      


Xaa Val Ala Asp Met Glu Asp Leu Leu Glu Asp Ile Gln Val Tyr Met 
            20                  25                  30          


Glu Leu Glu Gln Gly Lys Asn Ala Asp Phe Trp Arg Asp Met Xaa Xaa 
        35                  40                  45              


Ile Xaa Glu Asp Glu Ile Ser Lys Leu Arg Lys Leu Glu Ala Ser Gly 
    50                  55                  60                  


Lys Gly Pro Gly His Arg Gly Gln Asn Pro Arg Trp Trp Pro Gln Pro 
65                  70                  75                  80  


Gly His Gly Leu Leu Gly Glu Pro Pro Ala Ala Ala Ser Cys Pro His 
                85                  90                  95      


Gly Xaa Gly Pro Val Ser Xaa Arg Leu Arg Glu Arg His Gln Asp Val 
            100                 105                 110         


Leu Arg Gln Lys Leu Tyr Lys Leu Lys Gln Glu Gln Gly Val Glu Ser 
        115                 120                 125             


Glu Pro 
    130 


<210> 4747
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 4747
Lys Pro Arg Phe Phe Asn Arg Val His Xaa Gly Phe Glu Trp Asn Lys 
1               5                   10                  15      


Tyr Asn Gln Xaa His Tyr Asp Phe Asp Asn Pro Pro Pro Lys Ile Val 
            20                  25                  30          


Gln Gly Tyr Lys Phe Asn Ile Phe Tyr Pro Asp Leu Ile Asp Lys Arg 
        35                  40                  45              


Ser Xaa Pro Glu Tyr Phe Leu Glu Ala Cys Ala Asp Asn Lys Asp Phe 
    50                  55                  60                  


Ala Ile Leu Arg Phe His Ala Gly Pro Pro Tyr Glu Asp Ile Ala Phe 
65                  70                  75                  80  


Lys Ile Val Asn Arg Glu Trp Glu Tyr Ser His Arg His Gly Phe Arg 
                85                  90                  95      


Cys Gln Phe Ala Asn Gly Ile Phe Gln Leu Trp Phe His Phe Lys Arg 
            100                 105                 110         


Tyr Arg Tyr Arg Arg 
        115         


<210> 4748
<211> 758
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<400> 4748
Met Gly Arg Asp Xaa Arg Ser Arg Ser Arg Ser Ala Gly Arg Arg Gly 
1               5                   10                  15      


Arg Arg Arg Gln Ser Gln Ser Gly Ser Arg Ser Arg Ser Arg Ser His 
            20                  25                  30          


Gly Arg Arg Asn Arg Arg Arg Arg Glu Asp Glu Gly Arg Arg Arg Arg 
        35                  40                  45              


Arg Arg Arg Ser Arg Glu Arg Arg Ser Asp Ser Glu Glu Glu Arg Trp 
    50                  55                  60                  


Gln Arg Ser Gly Met Arg Ser Arg Ser Pro Pro Arg Pro Lys Trp His 
65                  70                  75                  80  


Ser Arg Asp Gly Ser Ser Gln Ser Asp Ser Gly Glu Glu Gln Ser Arg 
                85                  90                  95      


Gly Gln Trp Ala Arg Arg Arg Arg Arg Ala Arg Ser Trp Ser Pro Ser 
            100                 105                 110         


Ser Ser Ala Ser Ser Ser Ala Ser Pro Gly Arg Ser Gln Ser Pro Arg 
        115                 120                 125             


Ala Ala Ala Ala Ala Leu Ser Gln Gln Gln Ser Leu Gln Glu Arg Leu 
    130                 135                 140                 


Arg Leu Arg Glu Glu Arg Lys Gln Gln Glu Glu Leu Met Lys Ala Phe 
145                 150                 155                 160 


Glu Xaa Pro Glu Glu Lys Arg Ala Arg Arg Leu Ala Lys Lys Glu Ala 
                165                 170                 175     


Lys Glu Arg Lys Lys Arg Glu Lys Met Gly Trp Gly Glu Glu Tyr Met 
            180                 185                 190         


Gly Tyr Xaa Asn Xaa Asp Asn Pro Phe Gly Asp Asn Asn Leu Leu Gly 
        195                 200                 205             


Xaa Phe Ile Trp Asn Lys Ala Leu Glu Lys Lys Gly Ile Ser His Leu 
    210                 215                 220                 


Glu Glu Lys Glu Leu Lys Glu Arg Asn Lys Arg Ile Gln Glu Asp Asn 
225                 230                 235                 240 


Arg Leu Glu Leu Gln Lys Val Lys Gln Leu Arg Leu Glu Arg Glu Arg 
                245                 250                 255     


Glu Lys Ala Met Arg Glu Gln Glu Leu Glu Met Leu Gln Arg Glu Lys 
            260                 265                 270         


Glu Ala Glu His Phe Lys Xaa Trp Glu Glu Gln Glu Asp Asn Phe His 
        275                 280                 285             


Leu Gln Gln Ala Lys Leu Arg Ser Lys Ile Arg Ile Arg Asp Gly Arg 
    290                 295                 300                 


Ala Lys Pro Ile Asp Leu Leu Ala Lys Tyr Ile Ser Ala Glu Asp Asp 
305                 310                 315                 320 


Asp Leu Ala Val Glu Met His Glu Pro Tyr Xaa Phe Leu Asn Gly Leu 
                325                 330                 335     


Xaa Val Ala Asp Met Glu Asp Leu Leu Glu Asp Ile Gln Val Tyr Met 
            340                 345                 350         


Glu Leu Glu Gln Gly Lys Asn Ala Asp Phe Trp Arg Asp Met Xaa Xaa 
        355                 360                 365             


Ile Xaa Glu Asp Glu Ile Ser Lys Leu Arg Lys Leu Glu Ala Ser Gly 
    370                 375                 380                 


Lys Gly Pro Gly Glu Arg Arg Glu Gly Val Asn Ala Ser Val Ser Ser 
385                 390                 395                 400 


Asp Val Gln Ser Val Phe Lys Gly Lys Xaa Tyr Asn Gln Leu Gln Val 
                405                 410                 415     


Ile Phe Gln Gly Ile Glu Gly Lys Ile Arg Ala Gly Gly Pro Asn Leu 
            420                 425                 430         


Asp Met Gly Tyr Trp Glu Ser Leu Leu Gln Gln Leu Arg Ala His Met 
        435                 440                 445             


Ala Arg Ala Arg Leu Arg Glu Arg His Gln Asp Val Leu Arg Gln Lys 
    450                 455                 460                 


Leu Tyr Lys Leu Lys Gln Glu Gln Gly Val Glu Ser Glu Pro Leu Phe 
465                 470                 475                 480 


Pro Ile Leu Lys Gln Glu Pro Gln Ser Pro Ser Arg Ser Leu Glu Pro 
                485                 490                 495     


Glu Asp Ala Ala Pro Xaa Pro Pro Gly Pro Ser Ser Glu Gly Gly Pro 
            500                 505                 510         


Ala Glu Ala Glu Val Asp Gly Ala Xaa Pro Xaa Glu Gly Asp Gly Asp 
        515                 520                 525             


Gly Asp Gly Glu Gly Glu Gly Glu Gly Glu Ala Val Leu Met Glu Glu 
    530                 535                 540                 


Asp Leu Ile Gln Gln Ser Leu Asp Asp Tyr Asp Ala Gly Arg Tyr Ser 
545                 550                 555                 560 


Pro Arg Leu Leu Xaa Ala His Glu Leu Pro Leu Asp Ala His Val Leu 
                565                 570                 575     


Glu Pro Asp Glu Asp Leu Gln Arg Leu Gln Leu Ser Arg Gln Gln Leu 
            580                 585                 590         


Gln Val Xaa Gly Asp Ala Ser Glu Ser Ala Glu Asp Ile Phe Phe Arg 
        595                 600                 605             


Arg Ala Lys Glu Gly Met Gly Gln Asp Glu Ala Gln Phe Ser Val Glu 
    610                 615                 620                 


Met Pro Leu Xaa Gly Lys Ala Tyr Leu Trp Ala Asp Lys Tyr Arg Pro 
625                 630                 635                 640 


Arg Lys Pro Arg Phe Phe Asn Arg Val His Xaa Gly Phe Glu Trp Asn 
                645                 650                 655     


Lys Tyr Asn Gln Xaa His Tyr Asp Phe Asp Asn Pro Pro Pro Lys Ile 
            660                 665                 670         


Val Gln Gly Tyr Lys Phe Asn Ile Phe Tyr Pro Asp Leu Ile Asp Lys 
        675                 680                 685             


Arg Ser Xaa Pro Glu Tyr Phe Leu Glu Ala Cys Ala Asp Asn Lys Asp 
    690                 695                 700                 


Phe Ala Ile Leu Arg Phe His Ala Gly Pro Pro Tyr Glu Asp Ile Ala 
705                 710                 715                 720 


Phe Lys Ile Val Asn Arg Glu Trp Glu Tyr Ser His Arg His Gly Phe 
                725                 730                 735     


Arg Cys Gln Phe Ala Asn Gly Ile Phe Gln Leu Trp Phe His Phe Lys 
            740                 745                 750         


Arg Tyr Arg Tyr Arg Arg 
        755             


<210> 4749
<211> 291
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<400> 4749
Xaa Lys Gln Glu Gln Gly Val Glu Ser Glu Pro Leu Phe Pro Ile Leu 
1               5                   10                  15      


Lys Gln Glu Pro Gln Ser Pro Ser Arg Ser Leu Glu Pro Glu Asp Ala 
            20                  25                  30          


Ala Pro Xaa Pro Pro Gly Pro Ser Ser Glu Gly Gly Pro Ala Glu Ala 
        35                  40                  45              


Glu Val Asp Gly Ala Xaa Pro Xaa Glu Gly Asp Gly Asp Gly Asp Gly 
    50                  55                  60                  


Glu Gly Glu Gly Glu Gly Glu Ala Val Leu Met Glu Glu Asp Leu Ile 
65                  70                  75                  80  


Gln Gln Ser Leu Asp Asp Tyr Asp Ala Gly Arg Tyr Ser Pro Arg Leu 
                85                  90                  95      


Leu Xaa Ala His Glu Leu Pro Leu Asp Ala His Val Leu Glu Pro Asp 
            100                 105                 110         


Glu Asp Leu Gln Arg Leu Gln Leu Ser Arg Gln Gln Leu Gln Val Xaa 
        115                 120                 125             


Gly Asp Ala Ser Glu Ser Ala Glu Asp Ile Phe Phe Arg Arg Ala Lys 
    130                 135                 140                 


Glu Gly Met Gly Gln Asp Glu Ala Gln Phe Ser Val Glu Met Pro Leu 
145                 150                 155                 160 


Xaa Gly Lys Ala Tyr Leu Trp Ala Asp Lys Tyr Arg Pro Arg Lys Pro 
                165                 170                 175     


Arg Phe Phe Asn Arg Val His Xaa Gly Phe Glu Trp Asn Lys Tyr Asn 
            180                 185                 190         


Gln Xaa His Tyr Asp Phe Asp Asn Pro Pro Pro Lys Ile Val Gln Gly 
        195                 200                 205             


Tyr Lys Phe Asn Ile Phe Tyr Pro Asp Leu Ile Asp Lys Arg Ser Xaa 
    210                 215                 220                 


Pro Glu Tyr Phe Leu Glu Ala Cys Ala Asp Asn Lys Asp Phe Ala Ile 
225                 230                 235                 240 


Leu Arg Phe His Ala Gly Pro Pro Tyr Glu Asp Ile Ala Phe Lys Ile 
                245                 250                 255     


Val Asn Arg Glu Trp Glu Tyr Ser His Arg His Gly Phe Arg Cys Gln 
            260                 265                 270         


Phe Ala Asn Gly Ile Phe Gln Leu Trp Phe His Phe Lys Arg Tyr Arg 
        275                 280                 285             


Tyr Arg Arg 
    290     


<210> 4750
<211> 141
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<400> 4750
Xaa Lys Tyr Ile Ser Ala Glu Asp Asp Asp Leu Ala Val Glu Met His 
1               5                   10                  15      


Glu Pro Tyr Xaa Phe Leu Asn Gly Leu Xaa Val Ala Asp Met Glu Asp 
            20                  25                  30          


Leu Leu Glu Asp Ile Gln Val Tyr Met Glu Leu Glu Gln Gly Lys Asn 
        35                  40                  45              


Ala Asp Phe Trp Arg Asp Met Xaa Xaa Ile Xaa Glu Asp Glu Ile Ser 
    50                  55                  60                  


Lys Leu Arg Lys Leu Glu Ala Ser Gly Lys Gly Pro Gly Glu Arg Arg 
65                  70                  75                  80  


Glu Gly Val Asn Ala Ser Val Ser Ser Asp Val Gln Ser Val Phe Lys 
                85                  90                  95      


Gly Lys Xaa Tyr Asn Gln Leu Gln Val Ile Phe Gln Gly Ile Glu Gly 
            100                 105                 110         


Lys Ile Arg Ala Gly Gly Pro Asn Leu Asp Met Gly Tyr Trp Glu Ser 
        115                 120                 125             


Leu Leu Gln Gln Leu Arg Ala His Met Ala Arg Ala Arg 
    130                 135                 140     


<210> 4751
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<400> 4751
Met Gly Phe Gln Lys Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu Val 
1               5                   10                  15      


Leu Leu Gln Ala Gly Ser Leu His Ala Ala Pro Phe Arg Ser Ala Leu 
            20                  25                  30          


Glu Ser Ser Pro Ala Asp Pro Ala Xaa Leu Ser Glu Asp Glu Ala Arg 
        35                  40                  45              


Leu Leu Leu Ala Ala Leu Val Gln Asp Tyr Val Gln Met Lys Ala Ser 
    50                  55                  60                  


Glu Leu Glu Gln Glu Gln Glu Arg Glu Gly Ser Arg Ile Ile Ala Gln 
65                  70                  75                  80  


Lys Arg Ala Cys Asp Xaa Ala Xaa Cys Val Xaa His Arg Leu Ala Gly 
                85                  90                  95      


Leu Leu Ser Arg Ser Gly Gly Val Val Lys Asn Asn Phe Val Pro Xaa 
            100                 105                 110         


Asn Val Gly Ser Lys Ala Phe Gly Arg Arg Arg Arg Asp Leu Gln Ala 
        115                 120                 125             


<210> 4752
<211> 141
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<400> 4752
Met Gly Phe Gln Lys Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu Val 
1               5                   10                  15      


Leu Leu Gln Ala Gly Ser Leu His Ala Ala Pro Phe Arg Ser Ala Leu 
            20                  25                  30          


Glu Ser Ser Pro Ala Asp Pro Ala Xaa Leu Ser Glu Asp Glu Ala Arg 
        35                  40                  45              


Leu Leu Leu Ala Ala Leu Val Gln Asp Tyr Val Gln Met Lys Ala Ser 
    50                  55                  60                  


Glu Leu Glu Gln Glu Gln Glu Arg Glu Gly Ser Ser Leu Asp Ser Pro 
65                  70                  75                  80  


Arg Ser Lys Arg Cys Gly Asn Leu Ser Xaa Cys Met Leu Gly Xaa Tyr 
                85                  90                  95      


Xaa Gln Asp Phe Asn Lys Phe His Xaa Phe Pro Gln Xaa Ala Ile Gly 
            100                 105                 110         


Val Gly Ala Pro Gly Lys Lys Arg Asp Met Ser Ser Asp Leu Glu Arg 
        115                 120                 125             


Asp His Arg Pro His Asn His Cys Pro Glu Glu Ser Leu 
    130                 135                 140     


<210> 4753
<211> 141
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<400> 4753
Met Gly Phe Gln Lys Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu Val 
1               5                   10                  15      


Leu Leu Gln Ala Gly Ser Leu His Ala Ala Pro Phe Arg Ser Ala Leu 
            20                  25                  30          


Glu Ser Ser Pro Ala Asp Pro Ala Xaa Leu Ser Glu Asp Glu Ala Arg 
        35                  40                  45              


Leu Leu Leu Ala Ala Leu Val Gln Asp Tyr Val Gln Met Lys Ala Ser 
    50                  55                  60                  


Glu Leu Glu Gln Glu Gln Glu Arg Glu Gly Ser Ser Leu Asp Ser Pro 
65                  70                  75                  80  


Arg Ser Lys Arg Cys Gly Asn Leu Ser Xaa Cys Met Leu Gly Xaa Tyr 
                85                  90                  95      


Xaa Gln Asp Phe Asn Lys Phe His Xaa Phe Pro Gln Xaa Ala Ile Gly 
            100                 105                 110         


Val Gly Ala Pro Gly Lys Lys Arg Asp Met Ser Ser Asp Leu Glu Arg 
        115                 120                 125             


Asp His Arg Pro His Val Ser Met Pro Gln Asn Ala Asn 
    130                 135                 140     


<210> 4754
<211> 127
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 4754
Met Gly Phe Arg Lys Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu Val 
1               5                   10                  15      


Leu Tyr Gln Ala Gly Ser Leu Gln Ala Ala Pro Phe Arg Ser Ala Leu 
            20                  25                  30          


Glu Ser Ser Pro Asp Pro Ala Xaa Leu Ser Lys Glu Asp Ala Arg Leu 
        35                  40                  45              


Leu Leu Ala Ala Leu Val Gln Asp Tyr Val Gln Met Lys Ala Ser Glu 
    50                  55                  60                  


Leu Lys Gln Glu Gln Glu Xaa Gln Gly Ser Ser Ser Ala Ala Gln Lys 
65                  70                  75                  80  


Arg Ala Cys Asn Xaa Ala Xaa Cys Val Xaa His Arg Leu Ala Gly Leu 
                85                  90                  95      


Leu Ser Arg Ser Gly Gly Met Val Lys Ser Asn Phe Val Pro Xaa Asn 
            100                 105                 110         


Val Gly Ser Lys Ala Phe Gly Arg Arg Arg Arg Asp Leu Gln Ala 
        115                 120                 125         


<210> 4755
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<400> 4755
Met Lys Lys Glu Ala Asn Leu Gln Arg Gly Gly Met Gly Phe Arg Lys 
1               5                   10                  15      


Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu Val Leu Tyr Gln Ala Gly 
            20                  25                  30          


Ser Leu Gln Ala Ala Pro Phe Arg Ser Ala Leu Glu Ser Ser Pro Asp 
        35                  40                  45              


Pro Ala Xaa Leu Ser Lys Glu Asp Ala Arg Leu Leu Leu Ala Ala Leu 
    50                  55                  60                  


Val Gln Asp Tyr Val Gln Met Lys Ala Ser Glu Leu Lys Gln Glu Gln 
65                  70                  75                  80  


Glu Xaa Gln Gly Ser Ser Ser Ala Ala Gln Lys Arg Ala Cys Asn Xaa 
                85                  90                  95      


Ala Xaa Cys Val Xaa His Arg Leu Ala Gly Leu Leu Ser Arg Ser Gly 
            100                 105                 110         


Gly Met Val Lys Ser Asn Phe Val Pro Xaa Asn Val Gly Ser Lys Ala 
        115                 120                 125             


Phe Gly Arg Arg Arg Arg Asp Leu Gln Ala 
    130                 135             


<210> 4756
<211> 105
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 4756
Met Glu Glu Ser Pro Leu Ser Arg Ala Pro Ser Arg Gly Gly Val Asn 
1               5                   10                  15      


Phe Leu Asn Val Ala Arg Xaa Tyr Ile Pro Asn Xaa Lys Val Glu Cys 
            20                  25                  30          


His Tyr Xaa Leu Pro Pro Gly Xaa Met Pro Ser Ala Ser Asp Trp Ile 
        35                  40                  45              


Gly Ile Phe Lys Val Glu Ala Ala Cys Val Arg Asp Tyr His Xaa Phe 
    50                  55                  60                  


Val Trp Ser Ser Val Pro Glu Ser Xaa Xaa Asp Gly Ser Pro Ile His 
65                  70                  75                  80  


Xaa Ser Val Gln Phe Gln Ala Ser Tyr Leu Pro Lys Pro Gly Ala Gln 
                85                  90                  95      


Leu Tyr Gln Phe Arg Tyr Val Asn Arg 
            100                 105 


<210> 4757
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 4757
Met Glu Glu Ser Pro Leu Ser Arg Ala Pro Ser Arg Gly Gly Val Asn 
1               5                   10                  15      


Phe Leu Asn Val Ala Arg Xaa Tyr Ile Pro Asn Xaa Lys Val Glu Cys 
            20                  25                  30          


His Tyr Xaa Leu Pro Pro Gly Xaa Met Pro Ser Ala Ser Asp Trp Ile 
        35                  40                  45              


Gly Ile Phe Lys Val Glu Ala Ala Cys Val Arg Asp Tyr His Xaa Phe 
    50                  55                  60                  


Val Trp Ser Ser Val Pro Glu Ser Xaa Xaa Asp Gly Ser Pro Ile His 
65                  70                  75                  80  


Xaa Ser Val Gln Phe Gln Ala Ser Tyr Leu Pro Lys Pro Gly Ala Gln 
                85                  90                  95      


Leu Tyr Gln Phe Arg Tyr Val Asn Arg Gln Gly Gln Val Cys Gly Gln 
            100                 105                 110         


Ser Pro Pro 
        115 


<210> 4758
<211> 120
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 4758
Met Glu Glu Ser Pro Leu Ser Arg Ala Pro Ser Arg Gly Gly Val Asn 
1               5                   10                  15      


Phe Leu Asn Val Ala Arg Xaa Tyr Ile Pro Asn Xaa Lys Val Glu Cys 
            20                  25                  30          


His Tyr Xaa Leu Pro Pro Gly Xaa Met Pro Ser Ala Ser Asp Trp Ile 
        35                  40                  45              


Gly Ile Phe Lys Val Glu Ala Ala Cys Val Arg Asp Tyr His Xaa Phe 
    50                  55                  60                  


Val Trp Ser Ser Val Pro Glu Ser Xaa Xaa Asp Gly Ser Pro Ile His 
65                  70                  75                  80  


Xaa Ser Val Gln Phe Gln Ala Ser Tyr Leu Pro Lys Pro Gly Ala Gln 
                85                  90                  95      


Leu Tyr Gln Phe Arg Tyr Val Asn Arg Gln Gly Gln Val Cys Gly Gln 
            100                 105                 110         


Ser Pro Pro Phe Gln Phe Arg Glu 
        115                 120 


<210> 4759
<211> 134
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 4759
Met Glu Glu Ser Pro Leu Ser Arg Ala Pro Ser Arg Gly Gly Val Asn 
1               5                   10                  15      


Phe Leu Asn Val Ala Arg Xaa Tyr Ile Pro Asn Xaa Lys Val Glu Cys 
            20                  25                  30          


His Tyr Xaa Leu Pro Pro Gly Xaa Met Pro Ser Ala Ser Asp Trp Ile 
        35                  40                  45              


Gly Ile Phe Lys Val Glu Ala Ala Cys Val Arg Asp Tyr His Xaa Phe 
    50                  55                  60                  


Val Trp Ser Ser Val Pro Glu Ser Xaa Xaa Asp Gly Ser Pro Ile His 
65                  70                  75                  80  


Xaa Ser Val Gln Phe Gln Ala Ser Tyr Leu Pro Lys Pro Gly Ala Gln 
                85                  90                  95      


Leu Tyr Gln Phe Arg Tyr Val Asn Arg Gln Gly Gln Val Cys Gly Gln 
            100                 105                 110         


Ser Pro Pro Phe Gln Phe Arg Glu Pro Arg Pro Met Asp Glu Leu Val 
        115                 120                 125             


Xaa Leu Glu Glu Ala Asp 
    130                 


<210> 4760
<211> 149
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<400> 4760
Met Glu Glu Ser Pro Leu Ser Arg Ala Pro Ser Arg Gly Gly Val Asn 
1               5                   10                  15      


Phe Leu Asn Val Ala Arg Xaa Tyr Ile Pro Asn Xaa Lys Val Glu Cys 
            20                  25                  30          


His Tyr Xaa Leu Pro Pro Gly Xaa Met Pro Ser Ala Ser Asp Trp Ile 
        35                  40                  45              


Gly Ile Phe Lys Val Glu Ala Ala Cys Val Arg Asp Tyr His Xaa Phe 
    50                  55                  60                  


Val Trp Ser Ser Val Pro Glu Ser Xaa Xaa Asp Gly Ser Pro Ile His 
65                  70                  75                  80  


Xaa Ser Val Gln Phe Gln Ala Ser Tyr Leu Pro Lys Pro Gly Ala Gln 
                85                  90                  95      


Leu Tyr Gln Phe Arg Tyr Val Asn Arg Gln Gly Gln Val Cys Gly Gln 
            100                 105                 110         


Ser Pro Pro Phe Gln Phe Arg Glu Pro Arg Pro Met Asp Glu Leu Val 
        115                 120                 125             


Xaa Leu Glu Glu Ala Asp Gly Gly Ser Asp Ile Leu Leu Val Val Pro 
    130                 135                 140                 


Lys Ala Xaa Val Leu 
145                 


<210> 4761
<211> 160
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<400> 4761
Met Glu Glu Ser Pro Leu Ser Arg Ala Pro Ser Arg Gly Gly Val Asn 
1               5                   10                  15      


Phe Leu Asn Val Ala Arg Xaa Tyr Ile Pro Asn Xaa Lys Val Glu Cys 
            20                  25                  30          


His Tyr Xaa Leu Pro Pro Gly Xaa Met Pro Ser Ala Ser Asp Trp Ile 
        35                  40                  45              


Gly Ile Phe Lys Val Glu Ala Ala Cys Val Arg Asp Tyr His Xaa Phe 
    50                  55                  60                  


Val Trp Ser Ser Val Pro Glu Ser Xaa Xaa Asp Gly Ser Pro Ile His 
65                  70                  75                  80  


Xaa Ser Val Gln Phe Gln Ala Ser Tyr Leu Pro Lys Pro Gly Ala Gln 
                85                  90                  95      


Leu Tyr Gln Phe Arg Tyr Val Asn Arg Gln Gly Gln Val Cys Gly Gln 
            100                 105                 110         


Ser Pro Pro Phe Gln Phe Arg Glu Pro Arg Pro Met Asp Glu Leu Val 
        115                 120                 125             


Xaa Leu Glu Glu Ala Asp Gly Gly Ser Asp Ile Leu Leu Val Val Pro 
    130                 135                 140                 


Lys Ala Xaa Val Leu Gln Asn Gln Leu Asp Glu Ser Gln Gln Glu Arg 
145                 150                 155                 160 


<210> 4762
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<400> 4762
Met Glu Glu Ser Pro Leu Ser Arg Ala Pro Ser Arg Gly Gly Val Asn 
1               5                   10                  15      


Phe Leu Asn Val Ala Arg Xaa Tyr Ile Pro Asn Xaa Lys Val Glu Cys 
            20                  25                  30          


His Tyr Xaa Leu Pro Pro Gly Xaa Met Pro Ser Ala Ser Asp Trp Ile 
        35                  40                  45              


Gly Ile Phe Lys Val Glu Ala Ala Cys Val Arg Asp Tyr His Xaa Phe 
    50                  55                  60                  


Val Trp Ser Ser Val Pro Glu Ser Xaa Xaa Asp Gly Ser Pro Ile His 
65                  70                  75                  80  


Xaa Ser Val Gln Phe Gln Ala Ser Tyr Leu Pro Lys Pro Gly Ala Gln 
                85                  90                  95      


Leu Tyr Gln Phe Arg Tyr Val Asn Arg Gln Gly Gln Val Cys Gly Gln 
            100                 105                 110         


Ser Pro Pro Phe Gln Phe Arg Glu Pro Arg Pro Met Asp Glu Leu Val 
        115                 120                 125             


Xaa Leu Glu Glu Ala Asp Gly Gly Ser Asp Ile Leu Leu Val Val Pro 
    130                 135                 140                 


Lys Ala Xaa Val Leu Gln Asn Gln Leu Asp Glu Ser Gln Gln Glu Arg 
145                 150                 155                 160 


Asn Asp Leu Met 
                


<210> 4763
<211> 633
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<400> 4763
Met Glu Glu Ser Pro Leu Ser Arg Ala Pro Ser Arg Gly Gly Val Asn 
1               5                   10                  15      


Phe Leu Asn Val Ala Arg Xaa Tyr Ile Pro Asn Xaa Lys Val Glu Cys 
            20                  25                  30          


His Tyr Xaa Leu Pro Pro Gly Xaa Met Pro Ser Ala Ser Asp Trp Ile 
        35                  40                  45              


Gly Ile Phe Lys Val Glu Ala Ala Cys Val Arg Asp Tyr His Xaa Phe 
    50                  55                  60                  


Val Trp Ser Ser Val Pro Glu Ser Xaa Xaa Asp Gly Ser Pro Ile His 
65                  70                  75                  80  


Xaa Ser Val Gln Phe Gln Ala Ser Tyr Leu Pro Lys Pro Gly Ala Gln 
                85                  90                  95      


Leu Tyr Gln Phe Arg Tyr Val Asn Arg Gln Gly Gln Val Cys Gly Gln 
            100                 105                 110         


Ser Pro Pro Phe Gln Phe Arg Glu Pro Arg Pro Met Asp Glu Leu Val 
        115                 120                 125             


Xaa Leu Glu Glu Ala Asp Gly Gly Ser Asp Ile Leu Leu Val Val Pro 
    130                 135                 140                 


Lys Ala Xaa Val Leu Gln Asn Gln Leu Asp Glu Ser Gln Gln Glu Arg 
145                 150                 155                 160 


Asn Asp Leu Met Gln Leu Lys Leu Gln Leu Glu Gly Gln Val Xaa Glu 
                165                 170                 175     


Leu Arg Ser Arg Val Gln Glu Leu Glu Arg Ala Leu Ala Xaa Ala Arg 
            180                 185                 190         


Gln Glu His Xaa Glu Leu Met Glu Gln Tyr Lys Gly Ile Ser Arg Ser 
        195                 200                 205             


His Gly Glu Ile Xaa Glu Glu Arg Asp Ile Leu Ser Arg Gln Gln Gly 
    210                 215                 220                 


Asp His Val Ala Arg Ile Leu Glu Leu Glu Asp Asp Ile Gln Xaa Ile 
225                 230                 235                 240 


Ser Glu Lys Val Leu Xaa Lys Glu Val Glu Leu Asp Arg Leu Arg Asp 
                245                 250                 255     


Xaa Val Lys Ala Leu Xaa Arg Glu Gln Glu Lys Leu Leu Gly Gln Leu 
            260                 265                 270         


Lys Glu Val Gln Ala Asp Lys Glu Gln Ser Glu Ala Glu Leu Gln Val 
        275                 280                 285             


Ala Gln Gln Glu Asn His His Leu Asn Leu Asp Leu Lys Glu Ala Lys 
    290                 295                 300                 


Ser Trp Gln Glu Glu Gln Ser Ala Gln Ala Gln Arg Leu Lys Asp Lys 
305                 310                 315                 320 


Val Ala Gln Met Lys Asp Xaa Leu Gly Gln Ala Gln Gln Arg Val Ala 
                325                 330                 335     


Glu Leu Glu Pro Leu Lys Glu Gln Leu Arg Gly Ala Gln Glu Leu Ala 
            340                 345                 350         


Ala Ser Ser Gln Gln Lys Ala Xaa Leu Leu Gly Glu Glu Leu Ala Ser 
        355                 360                 365             


Ala Ala Ala Ala Arg Asp Arg Xaa Ile Ala Glu Leu His Arg Ser Arg 
    370                 375                 380                 


Leu Glu Val Ala Glu Val Asn Gly Arg Leu Ala Glu Leu Gly Leu His 
385                 390                 395                 400 


Leu Lys Glu Glu Lys Cys Gln Trp Ser Lys Glu Arg Ala Gly Leu Leu 
                405                 410                 415     


Gln Ser Val Glu Ala Glu Lys Asp Lys Ile Leu Lys Leu Ser Ala Glu 
            420                 425                 430         


Ile Leu Arg Leu Glu Lys Ala Val Gln Glu Glu Arg Xaa Gln Asn Gln 
        435                 440                 445             


Val Phe Lys Xaa Glu Leu Ala Arg Glu Lys Asp Ser Ser Leu Val Gln 
    450                 455                 460                 


Leu Ser Glu Ser Lys Arg Glu Leu Xaa Glu Leu Arg Ser Ala Leu Arg 
465                 470                 475                 480 


Val Leu Gln Lys Glu Lys Glu Gln Leu Gln Glu Glu Lys Gln Glu Leu 
                485                 490                 495     


Leu Glu Tyr Met Arg Lys Leu Glu Ala Arg Leu Glu Lys Val Ala Asp 
            500                 505                 510         


Glu Lys Trp Asn Glu Asp Ala Xaa Xaa Glu Asp Glu Glu Ala Ala Val 
        515                 520                 525             


Gly Leu Ser Cys Pro Ala Ala Leu Xaa Asp Ser Glu Asp Glu Ser Pro 
    530                 535                 540                 


Glu Asp Met Arg Leu Pro Pro Tyr Gly Leu Cys Glu Arg Gly Asp Pro 
545                 550                 555                 560 


Gly Ser Ser Pro Ala Gly Pro Arg Glu Ala Ser Pro Leu Val Val Ile 
                565                 570                 575     


Ser Gln Pro Ala Pro Ile Ser Pro His Leu Ser Gly Pro Ala Glu Asp 
            580                 585                 590         


Ser Ser Ser Asp Ser Glu Ala Glu Asp Glu Lys Ser Val Leu Met Ala 
        595                 600                 605             


Ala Val Gln Ser Gly Gly Glu Glu Ala Asn Leu Leu Leu Pro Glu Leu 
    610                 615                 620                 


Gly Ser Ala Phe Tyr Asp Met Ala Arg 
625                 630             


<210> 4764
<211> 690
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<400> 4764
Met Glu Glu Ser Pro Leu Ser Arg Ala Pro Ser Arg Gly Gly Val Asn 
1               5                   10                  15      


Phe Leu Asn Val Ala Arg Xaa Tyr Ile Pro Asn Xaa Lys Val Glu Cys 
            20                  25                  30          


His Tyr Xaa Leu Pro Pro Gly Xaa Met Pro Ser Ala Ser Asp Trp Ile 
        35                  40                  45              


Gly Ile Phe Lys Val Glu Ala Ala Cys Val Arg Asp Tyr His Xaa Phe 
    50                  55                  60                  


Val Trp Ser Ser Val Pro Glu Ser Xaa Xaa Asp Gly Ser Pro Ile His 
65                  70                  75                  80  


Xaa Ser Val Gln Phe Gln Ala Ser Tyr Leu Pro Lys Pro Gly Ala Gln 
                85                  90                  95      


Leu Tyr Gln Phe Arg Tyr Val Asn Arg Gln Gly Gln Val Cys Gly Gln 
            100                 105                 110         


Ser Pro Pro Phe Gln Phe Arg Glu Pro Arg Pro Met Asp Glu Leu Val 
        115                 120                 125             


Xaa Leu Glu Glu Ala Asp Gly Gly Ser Asp Ile Leu Leu Val Val Pro 
    130                 135                 140                 


Lys Ala Xaa Val Leu Gln Asn Gln Leu Asp Glu Ser Gln Gln Glu Arg 
145                 150                 155                 160 


Asn Asp Leu Met Gln Leu Lys Leu Gln Leu Glu Gly Gln Val Xaa Glu 
                165                 170                 175     


Leu Arg Ser Arg Val Gln Glu Leu Glu Arg Ala Leu Ala Xaa Ala Arg 
            180                 185                 190         


Gln Glu His Xaa Glu Leu Met Glu Gln Tyr Lys Gly Ile Ser Arg Ser 
        195                 200                 205             


His Gly Glu Ile Xaa Glu Glu Arg Asp Ile Leu Ser Arg Gln Gln Gly 
    210                 215                 220                 


Asp His Val Ala Arg Ile Leu Glu Leu Glu Asp Asp Ile Gln Xaa Ile 
225                 230                 235                 240 


Ser Glu Lys Val Leu Xaa Lys Glu Val Glu Leu Asp Arg Leu Arg Asp 
                245                 250                 255     


Xaa Val Lys Ala Leu Xaa Arg Glu Gln Glu Lys Leu Leu Gly Gln Leu 
            260                 265                 270         


Lys Glu Val Gln Ala Asp Lys Glu Gln Ser Glu Ala Glu Leu Gln Val 
        275                 280                 285             


Ala Gln Gln Glu Asn His His Leu Asn Leu Asp Leu Lys Glu Ala Lys 
    290                 295                 300                 


Ser Trp Gln Glu Glu Gln Ser Ala Gln Ala Gln Arg Leu Lys Asp Lys 
305                 310                 315                 320 


Val Ala Gln Met Lys Asp Xaa Leu Gly Gln Ala Gln Gln Arg Val Ala 
                325                 330                 335     


Glu Leu Glu Pro Leu Lys Glu Gln Leu Arg Gly Ala Gln Glu Leu Ala 
            340                 345                 350         


Ala Ser Ser Gln Gln Lys Ala Xaa Leu Leu Gly Glu Glu Leu Ala Ser 
        355                 360                 365             


Ala Ala Ala Ala Arg Asp Arg Xaa Ile Ala Glu Leu His Arg Ser Arg 
    370                 375                 380                 


Leu Glu Val Ala Glu Val Asn Gly Arg Leu Ala Glu Leu Gly Leu His 
385                 390                 395                 400 


Leu Lys Glu Glu Lys Cys Gln Trp Ser Lys Glu Arg Ala Gly Leu Leu 
                405                 410                 415     


Gln Ser Val Glu Ala Glu Lys Asp Lys Ile Leu Lys Leu Ser Ala Glu 
            420                 425                 430         


Ile Leu Arg Leu Glu Lys Ala Val Gln Glu Glu Arg Xaa Gln Asn Gln 
        435                 440                 445             


Val Phe Lys Xaa Glu Leu Ala Arg Glu Lys Asp Ser Ser Leu Val Gln 
    450                 455                 460                 


Leu Ser Glu Ser Lys Arg Glu Leu Xaa Glu Leu Arg Ser Ala Leu Arg 
465                 470                 475                 480 


Val Leu Gln Lys Glu Lys Glu Gln Leu Gln Glu Glu Lys Gln Glu Leu 
                485                 490                 495     


Leu Glu Tyr Met Arg Lys Leu Glu Ala Arg Leu Glu Lys Val Ala Asp 
            500                 505                 510         


Glu Lys Trp Asn Glu Asp Ala Xaa Xaa Glu Asp Glu Glu Ala Ala Val 
        515                 520                 525             


Gly Leu Ser Cys Pro Ala Ala Leu Xaa Asp Ser Glu Asp Glu Ser Pro 
    530                 535                 540                 


Glu Asp Met Arg Leu Pro Pro Tyr Gly Leu Cys Glu Arg Gly Asp Pro 
545                 550                 555                 560 


Gly Ser Ser Pro Ala Gly Pro Arg Glu Ala Ser Pro Leu Val Val Ile 
                565                 570                 575     


Ser Gln Pro Ala Pro Ile Ser Pro His Leu Ser Gly Pro Ala Glu Asp 
            580                 585                 590         


Ser Ser Ser Asp Ser Ala Glu Asp Glu Lys Ser Val Leu Met Ala Ala 
        595                 600                 605             


Val Gln Ser Gly Gly Glu Glu Ala Asn Leu Leu Leu Pro Glu Leu Gly 
    610                 615                 620                 


Ser Ala Phe Tyr Asp Met Ala Ser Gly Phe Xaa Val Gly Xaa Leu Ser 
625                 630                 635                 640 


Glu Xaa Ser Xaa Gly Gly Pro Ala Xaa Pro Xaa Trp Lys Glu Cys Pro 
                645                 650                 655     


Ile Cys Lys Glu Arg Phe Pro Ala Glu Ser Asp Lys Asp Ala Leu Glu 
            660                 665                 670         


Asp His Met Asp Gly His Phe Phe Phe Ser Xaa Gln Asp Pro Phe Xaa 
        675                 680                 685             


Phe Glu 
    690 


<210> 4765
<211> 691
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<400> 4765
Met Glu Glu Ser Pro Leu Ser Arg Ala Pro Ser Arg Gly Gly Val Asn 
1               5                   10                  15      


Phe Leu Asn Val Ala Arg Xaa Tyr Ile Pro Asn Xaa Lys Val Glu Cys 
            20                  25                  30          


His Tyr Xaa Leu Pro Pro Gly Xaa Met Pro Ser Ala Ser Asp Trp Ile 
        35                  40                  45              


Gly Ile Phe Lys Val Glu Ala Ala Cys Val Arg Asp Tyr His Xaa Phe 
    50                  55                  60                  


Val Trp Ser Ser Val Pro Glu Ser Xaa Xaa Asp Gly Ser Pro Ile His 
65                  70                  75                  80  


Xaa Ser Val Gln Phe Gln Ala Ser Tyr Leu Pro Lys Pro Gly Ala Gln 
                85                  90                  95      


Leu Tyr Gln Phe Arg Tyr Val Asn Arg Gln Gly Gln Val Cys Gly Gln 
            100                 105                 110         


Ser Pro Pro Phe Gln Phe Arg Glu Pro Arg Pro Met Asp Glu Leu Val 
        115                 120                 125             


Xaa Leu Glu Glu Ala Asp Gly Gly Ser Asp Ile Leu Leu Val Val Pro 
    130                 135                 140                 


Lys Ala Xaa Val Leu Gln Asn Gln Leu Asp Glu Ser Gln Gln Glu Arg 
145                 150                 155                 160 


Asn Asp Leu Met Gln Leu Lys Leu Gln Leu Glu Gly Gln Val Xaa Glu 
                165                 170                 175     


Leu Arg Ser Arg Val Gln Glu Leu Glu Arg Ala Leu Ala Xaa Ala Arg 
            180                 185                 190         


Gln Glu His Xaa Glu Leu Met Glu Gln Tyr Lys Gly Ile Ser Arg Ser 
        195                 200                 205             


His Gly Glu Ile Xaa Glu Glu Arg Asp Ile Leu Ser Arg Gln Gln Gly 
    210                 215                 220                 


Asp His Val Ala Arg Ile Leu Glu Leu Glu Asp Asp Ile Gln Xaa Ile 
225                 230                 235                 240 


Ser Glu Lys Val Leu Xaa Lys Glu Val Glu Leu Asp Arg Leu Arg Asp 
                245                 250                 255     


Xaa Val Lys Ala Leu Xaa Arg Glu Gln Glu Lys Leu Leu Gly Gln Leu 
            260                 265                 270         


Lys Glu Val Gln Ala Asp Lys Glu Gln Ser Glu Ala Glu Leu Gln Val 
        275                 280                 285             


Ala Gln Gln Glu Asn His His Leu Asn Leu Asp Leu Lys Glu Ala Lys 
    290                 295                 300                 


Ser Trp Gln Glu Glu Gln Ser Ala Gln Ala Gln Arg Leu Lys Asp Lys 
305                 310                 315                 320 


Val Ala Gln Met Lys Asp Xaa Leu Gly Gln Ala Gln Gln Arg Val Ala 
                325                 330                 335     


Glu Leu Glu Pro Leu Lys Glu Gln Leu Arg Gly Ala Gln Glu Leu Ala 
            340                 345                 350         


Ala Ser Ser Gln Gln Lys Ala Xaa Leu Leu Gly Glu Glu Leu Ala Ser 
        355                 360                 365             


Ala Ala Ala Ala Arg Asp Arg Xaa Ile Ala Glu Leu His Arg Ser Arg 
    370                 375                 380                 


Leu Glu Val Ala Glu Val Asn Gly Arg Leu Ala Glu Leu Gly Leu His 
385                 390                 395                 400 


Leu Lys Glu Glu Lys Cys Gln Trp Ser Lys Glu Arg Ala Gly Leu Leu 
                405                 410                 415     


Gln Ser Val Glu Ala Glu Lys Asp Lys Ile Leu Lys Leu Ser Ala Glu 
            420                 425                 430         


Ile Leu Arg Leu Glu Lys Ala Val Gln Glu Glu Arg Xaa Gln Asn Gln 
        435                 440                 445             


Val Phe Lys Xaa Glu Leu Ala Arg Glu Lys Asp Ser Ser Leu Val Gln 
    450                 455                 460                 


Leu Ser Glu Ser Lys Arg Glu Leu Xaa Glu Leu Arg Ser Ala Leu Arg 
465                 470                 475                 480 


Val Leu Gln Lys Glu Lys Glu Gln Leu Gln Glu Glu Lys Gln Glu Leu 
                485                 490                 495     


Leu Glu Tyr Met Arg Lys Leu Glu Ala Arg Leu Glu Lys Val Ala Asp 
            500                 505                 510         


Glu Lys Trp Asn Glu Asp Ala Xaa Xaa Glu Asp Glu Glu Ala Ala Val 
        515                 520                 525             


Gly Leu Ser Cys Pro Ala Ala Leu Xaa Asp Ser Glu Asp Glu Ser Pro 
    530                 535                 540                 


Glu Asp Met Arg Leu Pro Pro Tyr Gly Leu Cys Glu Arg Gly Asp Pro 
545                 550                 555                 560 


Gly Ser Ser Pro Ala Gly Pro Arg Glu Ala Ser Pro Leu Val Val Ile 
                565                 570                 575     


Ser Gln Pro Ala Pro Ile Ser Pro His Leu Ser Gly Pro Ala Glu Asp 
            580                 585                 590         


Ser Ser Ser Asp Ser Glu Ala Glu Asp Glu Lys Ser Val Leu Met Ala 
        595                 600                 605             


Ala Val Gln Ser Gly Gly Glu Glu Ala Asn Leu Leu Leu Pro Glu Leu 
    610                 615                 620                 


Gly Ser Ala Phe Tyr Asp Met Ala Ser Gly Phe Xaa Val Gly Xaa Leu 
625                 630                 635                 640 


Ser Glu Xaa Ser Xaa Gly Gly Pro Ala Xaa Pro Xaa Trp Lys Glu Cys 
                645                 650                 655     


Pro Ile Cys Lys Glu Arg Phe Pro Ala Glu Ser Asp Lys Asp Ala Leu 
            660                 665                 670         


Glu Asp His Met Asp Gly His Phe Phe Phe Ser Xaa Gln Asp Pro Phe 
        675                 680                 685             


Xaa Phe Glu 
    690     


<210> 4766
<211> 606
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<400> 4766
Met Glu Glu Ser Pro Leu Ser Arg Ala Pro Ser Arg Gly Gly Val Asn 
1               5                   10                  15      


Phe Leu Asn Val Ala Arg Xaa Tyr Ile Pro Asn Xaa Lys Val Glu Cys 
            20                  25                  30          


His Tyr Xaa Leu Pro Pro Gly Xaa Met Pro Ser Ala Ser Asp Trp Ile 
        35                  40                  45              


Gly Ile Phe Lys Val Glu Ala Ala Cys Val Arg Asp Tyr His Xaa Phe 
    50                  55                  60                  


Val Trp Ser Ser Val Pro Glu Ser Xaa Xaa Asp Gly Ser Pro Ile His 
65                  70                  75                  80  


Xaa Ser Val Gln Phe Gln Glu Pro Arg Pro Met Asp Glu Leu Val Xaa 
                85                  90                  95      


Leu Glu Glu Ala Asp Gly Gly Ser Asp Ile Leu Leu Val Val Pro Lys 
            100                 105                 110         


Ala Xaa Val Leu Gln Asn Gln Leu Asp Glu Ser Gln Gln Glu Arg Asn 
        115                 120                 125             


Asp Leu Met Gln Leu Lys Leu Gln Leu Glu Gly Gln Val Xaa Glu Leu 
    130                 135                 140                 


Arg Ser Arg Val Gln Glu Leu Glu Arg Ala Leu Ala Xaa Ala Arg Gln 
145                 150                 155                 160 


Glu His Xaa Glu Leu Met Glu Gln Tyr Lys Gly Ile Ser Arg Ser His 
                165                 170                 175     


Gly Glu Ile Xaa Glu Glu Arg Asp Ile Leu Ser Arg Gln Gln Gly Asp 
            180                 185                 190         


His Val Ala Arg Ile Leu Glu Leu Glu Asp Asp Ile Gln Xaa Ile Ser 
        195                 200                 205             


Glu Lys Val Leu Xaa Lys Glu Val Glu Leu Asp Arg Leu Arg Asp Xaa 
    210                 215                 220                 


Val Lys Ala Leu Xaa Arg Glu Gln Glu Lys Leu Leu Gly Gln Leu Lys 
225                 230                 235                 240 


Glu Val Gln Ala Asp Lys Glu Gln Ser Glu Ala Glu Leu Glu Pro Leu 
                245                 250                 255     


Lys Glu Gln Leu Arg Gly Ala Gln Glu Leu Ala Ala Ser Ser Gln Gln 
            260                 265                 270         


Lys Ala Xaa Leu Leu Gly Glu Glu Leu Ala Ser Ala Ala Ala Ala Arg 
        275                 280                 285             


Asp Arg Xaa Ile Ala Glu Leu His Arg Ser Arg Leu Glu Val Ala Glu 
    290                 295                 300                 


Val Asn Gly Arg Leu Ala Glu Leu Gly Leu His Leu Lys Glu Glu Lys 
305                 310                 315                 320 


Cys Gln Trp Ser Lys Glu Arg Ala Gly Leu Leu Gln Ser Val Glu Ala 
                325                 330                 335     


Glu Lys Asp Lys Ile Leu Lys Leu Ser Ala Glu Ile Leu Arg Leu Glu 
            340                 345                 350         


Lys Ala Val Gln Glu Glu Arg Xaa Gln Asn Gln Val Phe Lys Xaa Glu 
        355                 360                 365             


Leu Ala Arg Glu Lys Asp Ser Ser Leu Val Gln Leu Ser Glu Ser Lys 
    370                 375                 380                 


Arg Glu Leu Xaa Glu Leu Arg Ser Ala Leu Arg Val Leu Gln Lys Glu 
385                 390                 395                 400 


Lys Glu Gln Leu Gln Glu Glu Lys Gln Glu Leu Leu Glu Tyr Met Arg 
                405                 410                 415     


Lys Leu Glu Ala Arg Leu Glu Lys Val Ala Asp Glu Lys Trp Asn Glu 
            420                 425                 430         


Asp Ala Xaa Xaa Glu Asp Glu Glu Ala Ala Val Gly Leu Ser Cys Pro 
        435                 440                 445             


Ala Ala Leu Xaa Asp Ser Glu Asp Glu Ser Pro Glu Asp Met Arg Leu 
    450                 455                 460                 


Pro Pro Tyr Gly Leu Cys Glu Arg Gly Asp Pro Gly Ser Ser Pro Ala 
465                 470                 475                 480 


Gly Pro Arg Glu Ala Ser Pro Leu Val Val Ile Ser Gln Pro Ala Pro 
                485                 490                 495     


Ile Ser Pro His Leu Ser Gly Pro Ala Glu Asp Ser Ser Ser Asp Ser 
            500                 505                 510         


Glu Ala Glu Asp Glu Lys Ser Val Leu Met Ala Ala Val Gln Ser Gly 
        515                 520                 525             


Gly Glu Glu Ala Asn Leu Leu Leu Pro Glu Leu Gly Ser Ala Phe Tyr 
    530                 535                 540                 


Asp Met Ala Ser Gly Phe Xaa Val Gly Xaa Leu Ser Glu Xaa Ser Xaa 
545                 550                 555                 560 


Gly Gly Pro Ala Xaa Pro Xaa Trp Lys Glu Cys Pro Ile Cys Lys Glu 
                565                 570                 575     


Arg Phe Pro Ala Glu Ser Asp Lys Asp Ala Leu Glu Asp His Met Asp 
            580                 585                 590         


Gly His Phe Phe Phe Ser Xaa Gln Asp Pro Phe Xaa Phe Glu 
        595                 600                 605     


<210> 4767
<211> 161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<400> 4767
Met Glu Glu Ser Pro Leu Ser Arg Ala Pro Ser Arg Gly Gly Val Asn 
1               5                   10                  15      


Phe Leu Asn Val Ala Arg Xaa Tyr Ile Pro Asn Xaa Lys Val Glu Cys 
            20                  25                  30          


His Tyr Xaa Leu Pro Pro Gly Xaa Met Pro Ser Ala Ser Asp Trp Ile 
        35                  40                  45              


Gly Ile Phe Lys Val Glu Ala Ala Cys Val Arg Asp Tyr His Xaa Phe 
    50                  55                  60                  


Val Trp Ser Ser Val Pro Glu Ser Xaa Xaa Asp Gly Ser Pro Ile His 
65                  70                  75                  80  


Xaa Ser Val Gln Phe Gln Gly Xaa Arg Glu Asp Gly Lys Leu Gly Glu 
                85                  90                  95      


Arg Ser Gln Gly Ser Gly Gly Leu Lys Glu Ala Ser Tyr Leu Pro Lys 
            100                 105                 110         


Pro Gly Ala Gln Leu Tyr Gln Phe Arg Tyr Val Asn Arg Gln Gly Gln 
        115                 120                 125             


Val Cys Gly Gln Ser Pro Pro Phe Gln Phe Arg Glu Pro Arg Pro Met 
    130                 135                 140                 


Asp Glu Leu Val Xaa Leu Glu Glu Ala Asp Gly Gly Ser Asp Ile Leu 
145                 150                 155                 160 


Leu 
    


<210> 4768
<211> 232
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<400> 4768
Xaa Glu Lys Glu Gln Leu Gln Glu Glu Lys Gln Glu Leu Leu Glu Tyr 
1               5                   10                  15      


Met Arg Lys Leu Glu Ala Arg Leu Glu Lys Val Ala Asp Glu Lys Trp 
            20                  25                  30          


Asn Glu Asp Ala Xaa Xaa Glu Asp Glu Glu Ala Ala Val Gly Leu Ser 
        35                  40                  45              


Cys Pro Ala Ala Leu Xaa Asp Ser Glu Asp Glu Ser Pro Glu Asp Met 
    50                  55                  60                  


Arg Leu Pro Pro Tyr Gly Leu Cys Glu Arg Gly Asp Pro Gly Ser Ser 
65                  70                  75                  80  


Pro Ala Gly Pro Arg Glu Ala Ser Pro Leu Val Val Ile Ser Gln Pro 
                85                  90                  95      


Ala Pro Ile Ser Pro His Leu Ser Gly Pro Ala Glu Asp Ser Ser Ser 
            100                 105                 110         


Asp Ser Glu Ala Glu Asp Glu Lys Ser Val Leu Met Ala Ala Val Gln 
        115                 120                 125             


Ser Gly Gly Glu Glu Ala Asn Leu Leu Leu Pro Glu Leu Gly Ser Ala 
    130                 135                 140                 


Phe Tyr Asp Met Ala Ser Xaa Ile Phe Cys Arg Ala Gln Ile Ala Leu 
145                 150                 155                 160 


Leu Pro Leu Ser Pro Ala Ser Xaa Pro Ser Pro Xaa Xaa Ser Gly Phe 
                165                 170                 175     


Xaa Val Gly Xaa Leu Ser Glu Xaa Ser Xaa Gly Gly Pro Ala Xaa Pro 
            180                 185                 190         


Xaa Trp Lys Glu Cys Pro Ile Cys Lys Glu Arg Phe Pro Ala Glu Ser 
        195                 200                 205             


Asp Lys Asp Ala Leu Glu Asp His Met Asp Gly His Phe Phe Phe Ser 
    210                 215                 220                 


Xaa Gln Asp Pro Phe Xaa Phe Glu 
225                 230         


<210> 4769
<211> 508
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(435)
<223> Selenocysteine

<400> 4769
Met Gln Phe Ser Gly Glu Lys Ile Ser Gly Gln Arg Asp Leu Gln Lys 
1               5                   10                  15      


Ser Lys Met Arg Phe Xaa Phe Xaa Ser Arg Cys Leu Ala Leu Phe Leu 
            20                  25                  30          


Leu Leu Asn His Pro Xaa Pro Ile Leu Pro Ala Phe Ser Asn Gln Xaa 
        35                  40                  45              


Tyr Pro Xaa Ile Glu Pro Lys Pro Phe Leu Tyr Val Val Gly Arg Lys 
    50                  55                  60                  


Lys Met Met Asp Ala Gln Tyr Lys Cys Tyr Asp Arg Met Gln Gln Leu 
65                  70                  75                  80  


Pro Ala Tyr Gln Gly Glu Gly Pro Tyr Cys Asn Arg Xaa Trp Asp Gly 
                85                  90                  95      


Trp Leu Cys Trp Asp Asp Xaa Pro Ala Gly Val Leu Ser Tyr Gln Phe 
            100                 105                 110         


Cys Pro Asp Tyr Phe Pro Asp Phe Asp Pro Ser Glu Lys Val Xaa Lys 
        115                 120                 125             


Tyr Cys Asp Glu Lys Gly Val Trp Phe Lys His Pro Glu Asn Asn Arg 
    130                 135                 140                 


Xaa Trp Ser Asn Tyr Xaa Met Cys Asn Ala Phe Xaa Pro Glu Lys Leu 
145                 150                 155                 160 


Lys Asn Ala Tyr Val Leu Tyr Tyr Leu Ala Ile Val Gly His Ser Leu 
                165                 170                 175     


Ser Ile Phe Xaa Leu Val Ile Ser Leu Gly Ile Phe Val Phe Phe Arg 
            180                 185                 190         


Lys Leu Xaa Xaa Ile Phe Pro Leu Asn Trp Lys Tyr Arg Lys Ala Leu 
        195                 200                 205             


Ser Leu Gly Cys Gln Arg Val Xaa Leu His Lys Asn Met Phe Leu Xaa 
    210                 215                 220                 


Tyr Ile Leu Asn Ser Met Ile Ile Ile Ile His Leu Val Glu Val Val 
225                 230                 235                 240 


Pro Asn Gly Glu Leu Val Arg Arg Asp Pro Val Ser Cys Lys Ile Leu 
                245                 250                 255     


His Phe Phe His Gln Tyr Met Met Ala Cys Asn Tyr Phe Trp Met Leu 
            260                 265                 270         


Cys Glu Gly Ile Tyr Leu His Xaa Leu Ile Val Val Ala Val Phe Xaa 
        275                 280                 285             


Glu Lys Gln Arg Leu Arg Trp Tyr Tyr Leu Leu Gly Trp Gly Phe Pro 
    290                 295                 300                 


Leu Val Pro Xaa Xaa Ile His Ala Ile Xaa Arg Ala Val Tyr Phe Asn 
305                 310                 315                 320 


Asp Asn Cys Trp Leu Ser Val Glu Xaa His Leu Leu Tyr Ile Ile His 
                325                 330                 335     


Gly Pro Val Met Ala Ala Leu Val Val Asn Phe Phe Phe Leu Leu Asn 
            340                 345                 350         


Ile Val Arg Val Leu Val Xaa Lys Met Arg Glu Xaa His Glu Ala Glu 
        355                 360                 365             


Ser His Met Tyr Leu Lys Ala Val Lys Ala Xaa Met Ile Leu Val Pro 
    370                 375                 380                 


Leu Leu Gly Ile Gln Phe Val Val Phe Pro Trp Arg Pro Ser Asn Lys 
385                 390                 395                 400 


Met Leu Gly Lys Ile Tyr Asp Tyr Val Met His Ser Leu Ile His Phe 
                405                 410                 415     


Gln Gly Phe Phe Val Ala Xaa Ile Tyr Cys Phe Cys Asn Asn Glu Val 
            420                 425                 430         


Gln Xaa Xaa Val Lys Arg Gln Trp Ala Gln Phe Lys Ile Gln Trp Asn 
        435                 440                 445             


Gln Arg Trp Gly Arg Arg Pro Ser Asn Arg Ser Ala Arg Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Glu Ala Gly Asp Ile Pro Ile Tyr Ile Cys His Gln Glu 
465                 470                 475                 480 


Leu Arg Asn Glu Pro Ala Asn Asn Gln Gly Glu Glu Ser Ala Glu Ile 
                485                 490                 495     


Ile Pro Leu Asn Ile Ile Glu Gln Glu Ser Ser Ala 
            500                 505             


<210> 4770
<211> 162
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<400> 4770
Met Arg Phe Xaa Phe Xaa Ser Arg Cys Leu Ala Leu Phe Leu Leu Leu 
1               5                   10                  15      


Asn His Pro Xaa Pro Ile Leu Pro Ala Phe Ser Asn Gln Xaa Tyr Pro 
            20                  25                  30          


Xaa Ile Glu Pro Lys Pro Phe Leu Tyr Val Val Gly Arg Lys Lys Met 
        35                  40                  45              


Met Asp Ala Gln Tyr Lys Cys Tyr Asp Arg Met Gln Gln Leu Pro Ala 
    50                  55                  60                  


Tyr Gln Gly Glu Gly Pro Tyr Cys Asn Arg Xaa Trp Asp Gly Trp Leu 
65                  70                  75                  80  


Cys Trp Asp Asp Xaa Pro Ala Gly Val Leu Ser Tyr Gln Phe Cys Pro 
                85                  90                  95      


Asp Tyr Phe Pro Asp Phe Asp Pro Ser Glu Lys Val Xaa Lys Tyr Cys 
            100                 105                 110         


Asp Glu Lys Gly Val Trp Phe Lys His Pro Glu Asn Asn Arg Xaa Trp 
        115                 120                 125             


Ser Asn Tyr Xaa Met Cys Asn Ala Phe Xaa Pro Glu Lys Leu Lys Asn 
    130                 135                 140                 


Ala Tyr Val Leu Tyr Tyr Leu Ala Ile Val Gly His Ser Cys Gln Phe 
145                 150                 155                 160 


Ser Pro 
        


<210> 4771
<211> 290
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<400> 4771
Met Arg Phe Xaa Phe Xaa Ser Arg Cys Leu Ala Leu Phe Leu Leu Leu 
1               5                   10                  15      


Asn His Pro Xaa Pro Ile Leu Pro Ala Phe Ser Asn Gln Xaa Tyr Pro 
            20                  25                  30          


Xaa Ile Glu Pro Lys Pro Phe Leu Tyr Val Val Gly Arg Lys Lys Met 
        35                  40                  45              


Met Asp Ala Gln Tyr Lys Cys Tyr Asp Arg Met Gln Gln Leu Pro Ala 
    50                  55                  60                  


Tyr Gln Gly Glu Gly Pro Tyr Cys Asn Arg Xaa Trp Asp Gly Trp Leu 
65                  70                  75                  80  


Cys Trp Asp Asp Xaa Pro Ala Gly Val Leu Ser Tyr Gln Phe Cys Pro 
                85                  90                  95      


Asp Tyr Phe Pro Asp Phe Asp Pro Ser Glu Lys Val Xaa Lys Tyr Cys 
            100                 105                 110         


Asp Glu Lys Gly Val Trp Phe Lys His Pro Glu Asn Asn Arg Xaa Trp 
        115                 120                 125             


Ser Asn Tyr Xaa Met Cys Asn Ala Phe Xaa Pro Glu Lys Leu Lys Asn 
    130                 135                 140                 


Ala Tyr Val Leu Tyr Tyr Leu Ala Ile Val Gly His Ser Leu Ser Ile 
145                 150                 155                 160 


Phe Xaa Leu Val Ile Ser Leu Gly Ile Phe Val Phe Phe Arg Lys Leu 
                165                 170                 175     


Xaa Xaa Ile Phe Pro Leu Asn Trp Lys Tyr Arg Lys Ala Leu Ser Leu 
            180                 185                 190         


Gly Cys Gln Arg Val Xaa Leu His Lys Asn Met Phe Leu Xaa Tyr Ile 
        195                 200                 205             


Leu Asn Ser Met Ile Ile Ile Ile His Leu Val Glu Val Val Pro Asn 
    210                 215                 220                 


Gly Glu Leu Val Arg Arg Asp Pro Val Ser Cys Lys Ile Leu His Phe 
225                 230                 235                 240 


Phe His Gln Tyr Met Met Ala Cys Asn Tyr Phe Trp Met Leu Cys Glu 
                245                 250                 255     


Gly Ile Tyr Leu His Xaa Leu Ile Val Val Ala Val Phe Xaa Glu Lys 
            260                 265                 270         


Gln Arg Leu Arg Trp Tyr Tyr Leu Leu Gly Trp Ala Pro Ala Phe His 
        275                 280                 285             


Arg Asp 
    290 


<210> 4772
<211> 490
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(417)
<223> Selenocysteine

<400> 4772
Met Arg Phe Xaa Phe Xaa Ser Arg Cys Leu Ala Leu Phe Leu Leu Leu 
1               5                   10                  15      


Asn His Pro Xaa Pro Ile Leu Pro Ala Phe Ser Asn Gln Xaa Tyr Pro 
            20                  25                  30          


Xaa Ile Glu Pro Lys Pro Phe Leu Tyr Val Val Gly Arg Lys Lys Met 
        35                  40                  45              


Met Asp Ala Gln Tyr Lys Cys Tyr Asp Arg Met Gln Gln Leu Pro Ala 
    50                  55                  60                  


Tyr Gln Gly Glu Gly Pro Tyr Cys Asn Arg Xaa Trp Asp Gly Trp Leu 
65                  70                  75                  80  


Cys Trp Asp Asp Xaa Pro Ala Gly Val Leu Ser Tyr Gln Phe Cys Pro 
                85                  90                  95      


Asp Tyr Phe Pro Asp Phe Asp Pro Ser Glu Lys Val Xaa Lys Tyr Cys 
            100                 105                 110         


Asp Glu Lys Gly Val Trp Phe Lys His Pro Glu Asn Asn Arg Xaa Trp 
        115                 120                 125             


Ser Asn Tyr Xaa Met Cys Asn Ala Phe Xaa Pro Glu Lys Leu Lys Asn 
    130                 135                 140                 


Ala Tyr Val Leu Tyr Tyr Leu Ala Ile Val Gly His Ser Leu Ser Ile 
145                 150                 155                 160 


Phe Xaa Leu Val Ile Ser Leu Gly Ile Phe Val Phe Phe Arg Lys Leu 
                165                 170                 175     


Xaa Xaa Ile Phe Pro Leu Asn Trp Lys Tyr Arg Lys Ala Leu Ser Leu 
            180                 185                 190         


Gly Cys Gln Arg Val Xaa Leu His Lys Asn Met Phe Leu Xaa Tyr Ile 
        195                 200                 205             


Leu Asn Ser Met Ile Ile Ile Ile His Leu Val Glu Val Val Pro Asn 
    210                 215                 220                 


Gly Glu Leu Val Arg Arg Asp Pro Val Ser Cys Lys Ile Leu His Phe 
225                 230                 235                 240 


Phe His Gln Tyr Met Met Ala Cys Asn Tyr Phe Trp Met Leu Cys Glu 
                245                 250                 255     


Gly Ile Tyr Leu His Xaa Leu Ile Val Val Ala Val Phe Xaa Glu Lys 
            260                 265                 270         


Gln Arg Leu Arg Trp Tyr Tyr Leu Leu Gly Trp Gly Phe Pro Leu Val 
        275                 280                 285             


Pro Xaa Xaa Ile His Ala Ile Xaa Arg Ala Val Tyr Phe Asn Asp Asn 
    290                 295                 300                 


Cys Trp Leu Ser Val Glu Xaa His Leu Leu Tyr Ile Ile His Gly Pro 
305                 310                 315                 320 


Val Met Ala Ala Leu Val Val Asn Phe Phe Phe Leu Leu Asn Ile Val 
                325                 330                 335     


Arg Val Leu Val Xaa Lys Met Arg Glu Xaa His Glu Ala Glu Ser His 
            340                 345                 350         


Met Tyr Leu Lys Ala Val Lys Ala Xaa Met Ile Leu Val Pro Leu Leu 
        355                 360                 365             


Gly Ile Gln Phe Val Val Phe Pro Trp Arg Pro Ser Asn Lys Met Leu 
    370                 375                 380                 


Gly Lys Ile Tyr Asp Tyr Val Met His Ser Leu Ile His Phe Gln Gly 
385                 390                 395                 400 


Phe Phe Val Ala Xaa Ile Tyr Cys Phe Cys Asn Asn Glu Val Gln Xaa 
                405                 410                 415     


Xaa Val Lys Arg Gln Trp Ala Gln Phe Lys Ile Gln Trp Asn Gln Arg 
            420                 425                 430         


Trp Gly Arg Arg Pro Ser Asn Arg Ser Ala Arg Ala Ala Ala Ala Ala 
        435                 440                 445             


Ala Glu Ala Gly Asp Ile Pro Ile Tyr Ile Cys His Gln Glu Leu Arg 
    450                 455                 460                 


Asn Glu Pro Ala Asn Asn Gln Gly Glu Glu Ser Ala Glu Ile Ile Pro 
465                 470                 475                 480 


Leu Asn Ile Ile Glu Gln Glu Ser Ser Ala 
                485                 490 


<210> 4773
<211> 274
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<400> 4773
Met Arg Phe Xaa Phe Xaa Ser Arg Cys Leu Ala Leu Phe Leu Leu Leu 
1               5                   10                  15      


Asn His Pro Xaa Pro Ile Leu Pro Ala Phe Ser Asn Gln Xaa Tyr Pro 
            20                  25                  30          


Xaa Ile Glu Pro Lys Pro Phe Leu Tyr Val Val Gly Arg Lys Lys Met 
        35                  40                  45              


Met Asp Ala Gln Tyr Lys Cys Tyr Asp Arg Met Gln Gln Leu Pro Ala 
    50                  55                  60                  


Tyr Gln Gly Glu Gly Pro Tyr Cys Asn Arg Xaa Trp Asp Gly Trp Leu 
65                  70                  75                  80  


Cys Trp Asp Asp Xaa Pro Ala Gly Val Leu Ser Tyr Gln Phe Cys Pro 
                85                  90                  95      


Asp Tyr Phe Pro Asp Phe Asp Pro Ser Glu Lys Val Xaa Lys Tyr Cys 
            100                 105                 110         


Asp Glu Lys Gly Val Trp Phe Lys His Pro Glu Asn Asn Arg Xaa Trp 
        115                 120                 125             


Ser Asn Tyr Xaa Met Cys Asn Ala Phe Xaa Pro Glu Lys Leu Lys Asn 
    130                 135                 140                 


Ala Tyr Val Leu Tyr Tyr Leu Ala Ile Val Gly His Ser Leu Ser Ile 
145                 150                 155                 160 


Phe Xaa Leu Val Ile Ser Leu Gly Ile Phe Val Phe Phe Arg Ser Leu 
                165                 170                 175     


Gly Cys Gln Arg Val Xaa Leu His Lys Asn Met Phe Leu Xaa Tyr Ile 
            180                 185                 190         


Leu Asn Ser Met Ile Ile Ile Ile His Leu Val Glu Val Val Pro Asn 
        195                 200                 205             


Gly Glu Leu Val Arg Arg Asp Pro Val Ser Cys Lys Ile Leu His Phe 
    210                 215                 220                 


Phe His Gln Tyr Met Met Ala Cys Asn Tyr Phe Trp Met Leu Cys Glu 
225                 230                 235                 240 


Gly Ile Tyr Leu His Xaa Leu Ile Val Val Ala Val Phe Xaa Glu Lys 
                245                 250                 255     


Gln Arg Leu Arg Trp Tyr Tyr Leu Leu Gly Trp Ala Pro Ala Phe His 
            260                 265                 270         


Arg Asp 
        


<210> 4774
<211> 474
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(401)
<223> Selenocysteine

<400> 4774
Met Arg Phe Xaa Phe Xaa Ser Arg Cys Leu Ala Leu Phe Leu Leu Leu 
1               5                   10                  15      


Asn His Pro Xaa Pro Ile Leu Pro Ala Phe Ser Asn Gln Xaa Tyr Pro 
            20                  25                  30          


Xaa Ile Glu Pro Lys Pro Phe Leu Tyr Val Val Gly Arg Lys Lys Met 
        35                  40                  45              


Met Asp Ala Gln Tyr Lys Cys Tyr Asp Arg Met Gln Gln Leu Pro Ala 
    50                  55                  60                  


Tyr Gln Gly Glu Gly Pro Tyr Cys Asn Arg Xaa Trp Asp Gly Trp Leu 
65                  70                  75                  80  


Cys Trp Asp Asp Xaa Pro Ala Gly Val Leu Ser Tyr Gln Phe Cys Pro 
                85                  90                  95      


Asp Tyr Phe Pro Asp Phe Asp Pro Ser Glu Lys Val Xaa Lys Tyr Cys 
            100                 105                 110         


Asp Glu Lys Gly Val Trp Phe Lys His Pro Glu Asn Asn Arg Xaa Trp 
        115                 120                 125             


Ser Asn Tyr Xaa Met Cys Asn Ala Phe Xaa Pro Glu Lys Leu Lys Asn 
    130                 135                 140                 


Ala Tyr Val Leu Tyr Tyr Leu Ala Ile Val Gly His Ser Leu Ser Ile 
145                 150                 155                 160 


Phe Xaa Leu Val Ile Ser Leu Gly Ile Phe Val Phe Phe Arg Ser Leu 
                165                 170                 175     


Gly Cys Gln Arg Val Xaa Leu His Lys Asn Met Phe Leu Xaa Tyr Ile 
            180                 185                 190         


Leu Asn Ser Met Ile Ile Ile Ile His Leu Val Glu Val Val Pro Asn 
        195                 200                 205             


Gly Glu Leu Val Arg Arg Asp Pro Val Ser Cys Lys Ile Leu His Phe 
    210                 215                 220                 


Phe His Gln Tyr Met Met Ala Cys Asn Tyr Phe Trp Met Leu Cys Glu 
225                 230                 235                 240 


Gly Ile Tyr Leu His Xaa Leu Ile Val Val Ala Val Phe Xaa Glu Lys 
                245                 250                 255     


Gln Arg Leu Arg Trp Tyr Tyr Leu Leu Gly Trp Gly Phe Pro Leu Val 
            260                 265                 270         


Pro Xaa Xaa Ile His Ala Ile Xaa Arg Ala Val Tyr Phe Asn Asp Asn 
        275                 280                 285             


Cys Trp Leu Ser Val Glu Xaa His Leu Leu Tyr Ile Ile His Gly Pro 
    290                 295                 300                 


Val Met Ala Ala Leu Val Val Asn Phe Phe Phe Leu Leu Asn Ile Val 
305                 310                 315                 320 


Arg Val Leu Val Xaa Lys Met Arg Glu Xaa His Glu Ala Glu Ser His 
                325                 330                 335     


Met Tyr Leu Lys Ala Val Lys Ala Xaa Met Ile Leu Val Pro Leu Leu 
            340                 345                 350         


Gly Ile Gln Phe Val Val Phe Pro Trp Arg Pro Ser Asn Lys Met Leu 
        355                 360                 365             


Gly Lys Ile Tyr Asp Tyr Val Met His Ser Leu Ile His Phe Gln Gly 
    370                 375                 380                 


Phe Phe Val Ala Xaa Ile Tyr Cys Phe Cys Asn Asn Glu Val Gln Xaa 
385                 390                 395                 400 


Xaa Val Lys Arg Gln Trp Ala Gln Phe Lys Ile Gln Trp Asn Gln Arg 
                405                 410                 415     


Trp Gly Arg Arg Pro Ser Asn Arg Ser Ala Arg Ala Ala Ala Ala Ala 
            420                 425                 430         


Ala Glu Ala Gly Asp Ile Pro Ile Tyr Ile Cys His Gln Glu Leu Arg 
        435                 440                 445             


Asn Glu Pro Ala Asn Asn Gln Gly Glu Glu Ser Ala Glu Ile Ile Pro 
    450                 455                 460                 


Leu Asn Ile Ile Glu Gln Glu Ser Ser Ala 
465                 470                 


<210> 4775
<211> 37
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<400> 4775
Met Glu Lys Lys Cys Xaa Leu Tyr Phe Leu Val Leu Leu Pro Phe Phe 
1               5                   10                  15      


Met Ile Leu Val Xaa Ala Glu Leu Glu Glu Ser Pro Glu Asp Ser Ile 
            20                  25                  30          


Gln Leu Gly Val Xaa 
        35          


<210> 4776
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<400> 4776
Met Glu Lys Lys Cys Xaa Leu Tyr Phe Leu Val Leu Leu Pro Phe Phe 
1               5                   10                  15      


Met Ile Leu Val Xaa Ala Glu Leu Glu Glu Ser Pro Glu Asp Ser Ile 
            20                  25                  30          


Gln Leu Gly Val Xaa Arg Asn Lys Ile Met Xaa Ala Gln Tyr Glu Cys 
        35                  40                  45              


Tyr Gln Lys Ile Met Gln Asp Pro Ile Gln Gln Ala Glu Gly Val Tyr 
    50                  55                  60                  


Cys Asn Arg Xaa Trp Asp Gly Trp Leu Cys Trp Asn Asp Val 
65                  70                  75              


<210> 4777
<211> 461
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<400> 4777
Met Glu Lys Lys Cys Xaa Leu Tyr Phe Leu Val Leu Leu Pro Phe Phe 
1               5                   10                  15      


Met Ile Leu Val Xaa Ala Glu Leu Glu Glu Ser Pro Glu Asp Ser Ile 
            20                  25                  30          


Gln Leu Gly Val Xaa Arg Asn Lys Ile Met Xaa Ala Gln Tyr Glu Cys 
        35                  40                  45              


Tyr Gln Lys Ile Met Gln Asp Pro Ile Gln Gln Ala Glu Gly Val Tyr 
    50                  55                  60                  


Cys Asn Arg Xaa Trp Asp Gly Trp Leu Cys Trp Asn Asp Val Ala Ala 
65                  70                  75                  80  


Gly Xaa Glu Ser Met Gln Leu Cys Pro Asp Tyr Phe Gln Asp Phe Asp 
                85                  90                  95      


Pro Ser Glu Lys Val Xaa Lys Ile Cys Asp Gln Asp Gly Asn Trp Phe 
            100                 105                 110         


Arg His Pro Ala Ser Asn Arg Xaa Trp Xaa Asn Tyr Xaa Gln Cys Asn 
        115                 120                 125             


Val Asn Xaa His Glu Lys Val Lys Xaa Ala Leu Asn Leu Phe Tyr Leu 
    130                 135                 140                 


Xaa Ile Ile Gly His Gly Leu Ser Ile Ala Ser Leu Leu Ile Ser Leu 
145                 150                 155                 160 


Gly Ile Phe Phe Tyr Phe Lys Ser Leu Ser Cys Gln Arg Ile Xaa Leu 
                165                 170                 175     


His Lys Asn Leu Phe Phe Ser Phe Val Cys Asn Ser Val Val Xaa Ile 
            180                 185                 190         


Ile His Leu Xaa Ala Val Ala Asn Asn Gln Ala Leu Val Ala Xaa Asn 
        195                 200                 205             


Pro Val Ser Cys Lys Val Ser Gln Phe Ile His Leu Tyr Leu Met Gly 
    210                 215                 220                 


Cys Asn Tyr Phe Trp Met Leu Cys Glu Gly Ile Tyr Leu His Xaa Leu 
225                 230                 235                 240 


Ile Val Val Ala Val Phe Ala Glu Lys Gln His Leu Met Trp Tyr Tyr 
                245                 250                 255     


Phe Leu Gly Trp Gly Phe Pro Leu Ile Pro Ala Cys Ile His Ala Ile 
            260                 265                 270         


Ala Arg Ser Leu Tyr Tyr Asn Asp Asn Cys Trp Ile Ser Ser Asp Xaa 
        275                 280                 285             


His Leu Leu Tyr Ile Ile His Gly Pro Ile Cys Ala Ala Leu Leu Val 
    290                 295                 300                 


Asn Leu Phe Phe Leu Leu Asn Ile Val Arg Val Leu Ile Xaa Lys Leu 
305                 310                 315                 320 


Lys Val Xaa His Gln Ala Glu Ser Asn Leu Tyr Met Lys Ala Val Arg 
                325                 330                 335     


Ala Xaa Leu Ile Leu Val Pro Leu Leu Gly Ile Glu Phe Val Leu Ile 
            340                 345                 350         


Pro Trp Arg Pro Glu Gly Lys Ile Ala Glu Glu Val Tyr Asp Tyr Ile 
        355                 360                 365             


Met His Ile Leu Met His Phe Gln Gly Leu Leu Val Ser Xaa Ile Phe 
    370                 375                 380                 


Cys Phe Phe Asn Gly Glu Val Gln Ala Ile Leu Arg Arg Asn Trp Asn 
385                 390                 395                 400 


Gln Tyr Lys Ile Gln Phe Gly Asn Ser Phe Ser Asn Ser Glu Ala Leu 
                405                 410                 415     


Arg Ser Ala Ser Tyr Xaa Val Ser Xaa Ile Ser Asp Gly Pro Gly Tyr 
            420                 425                 430         


Ser His Asp Cys Pro Ser Glu His Leu Asn Gly Lys Ser Ile His Asp 
        435                 440                 445             


Ile Glu Asn Val Leu Leu Lys Pro Glu Asn Leu Tyr Asn 
    450                 455                 460     


<210> 4778
<211> 83
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 4778
Met Ala Asp Gln Leu Xaa Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala 
1               5                   10                  15      


Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Xaa Ile Xaa Xaa Lys Glu 
            20                  25                  30          


Leu Gly Xaa Val Met Arg Ser Leu Gly Gln Asn Pro Xaa Glu Ala Glu 
        35                  40                  45              


Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Trp Gln Trp Leu 
    50                  55                  60                  


Tyr Gln Cys Ser Arg Xaa Xaa Ser Arg His Asp Lys Leu Arg Arg Lys 
65                  70                  75                  80  


Xaa Asn Arg 
            


<210> 4779
<211> 150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 4779
Met Gln Ala Asp Gln Leu Xaa Glu Glu Gln Ile Ala Glu Phe Lys Glu 
1               5                   10                  15      


Ala Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Xaa Ile Xaa Xaa Lys 
            20                  25                  30          


Glu Leu Gly Xaa Val Met Arg Ser Leu Gly Gln Asn Pro Xaa Glu Ala 
        35                  40                  45              


Glu Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Xaa 
    50                  55                  60                  


Ile Asp Phe Pro Glu Phe Leu Xaa Met Met Ala Arg Lys Met Lys Asp 
65                  70                  75                  80  


Xaa Asp Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys 
                85                  90                  95      


Asp Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Xaa 
            100                 105                 110         


Asn Leu Gly Glu Lys Leu Xaa Asp Glu Glu Val Asp Glu Met Ile Arg 
        115                 120                 125             


Glu Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val 
    130                 135                 140                 


Gln Met Met Xaa Ala Lys 
145                 150 


<210> 4780
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<400> 4780
Met Arg Ser Leu Gly Gln Asn Pro Xaa Glu Ala Glu Leu Gln Asp Met 
1               5                   10                  15      


Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Xaa Ile Asp Phe Pro Glu 
            20                  25                  30          


Phe Leu Xaa Met Met Ala Arg Lys Met Lys Asp Xaa Asp Ser Glu Glu 
        35                  40                  45              


Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Cys Ser Arg Xaa Xaa 
    50                  55                  60                  


Ser Arg His Asp Lys Leu Arg Arg Lys Xaa Asn Arg 
65                  70                  75      


<210> 4781
<211> 98
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<400> 4781
Met Arg Ser Leu Gly Gln Asn Pro Xaa Glu Ala Glu Leu Gln Asp Met 
1               5                   10                  15      


Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Xaa Ile Asp Phe Pro Glu 
            20                  25                  30          


Phe Leu Xaa Met Met Ala Arg Lys Met Lys Asp Xaa Asp Ser Glu Glu 
        35                  40                  45              


Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp Gly Asn Gly Tyr 
    50                  55                  60                  


Ile Ser Ala Ala Glu Leu Arg His Val Met Xaa Asn Leu Gly Glu Lys 
65                  70                  75                  80  


Leu Xaa Asp Glu Glu Val Asp Glu Met Ile Arg Glu Ala Asp Ile Asp 
                85                  90                  95      


Gly Asp 
        


<210> 4782
<211> 65
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<400> 4782
Met Ala Asp Gln Leu Xaa Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala 
1               5                   10                  15      


Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Xaa Ile Xaa Xaa Lys Glu 
            20                  25                  30          


Leu Gly Xaa Val Met Arg Ser Leu Gly Gln Asn Pro Xaa Glu Ala Glu 
        35                  40                  45              


Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Trp Gln Trp Leu 
    50                  55                  60                  


Tyr 
65  


<210> 4783
<211> 196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<400> 4783
Met Ile Leu Ala His Cys Asn Leu Cys Cys Pro Xaa Ser Ser Asn Ser 
1               5                   10                  15      


Pro Gly Ser Val Ser Gln Val Ala Gly Ile Xaa Gly Val His His His 
            20                  25                  30          


Xaa Arg Leu Val Phe Val Phe Leu Gly Glu Met Gly Phe His His Val 
        35                  40                  45              


Gly Gln Ala Gly Leu Glu Leu Leu Xaa Ser Glu Phe Lys Glu Ala Phe 
    50                  55                  60                  


Ser Leu Phe Asp Lys Asp Gly Asp Gly Xaa Ile Xaa Xaa Lys Glu Leu 
65                  70                  75                  80  


Gly Xaa Val Met Arg Ser Leu Gly Gln Asn Pro Xaa Glu Ala Glu Leu 
                85                  90                  95      


Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Xaa Ile Asp 
            100                 105                 110         


Phe Pro Glu Phe Leu Xaa Met Met Ala Arg Lys Met Lys Asp Xaa Asp 
        115                 120                 125             


Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp Gly 
    130                 135                 140                 


Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Xaa Asn Leu 
145                 150                 155                 160 


Gly Glu Lys Leu Xaa Asp Glu Glu Val Asp Glu Met Ile Arg Glu Ala 
                165                 170                 175     


Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met 
            180                 185                 190         


Met Xaa Ala Lys 
        195     


<210> 4784
<211> 187
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<400> 4784
Ser Pro Ser Gly Glu Ser Glu Leu Ser Gly Cys Val Val Ala Ser Arg 
1               5                   10                  15      


Lys Pro Val Ala Leu Ala Ala Trp Leu Ala Leu Tyr Ile Ala Ser His 
            20                  25                  30          


Phe Ala Gln Gln Pro Cys Lys Ala Asp Gln Leu Xaa Glu Glu Gln Ile 
        35                  40                  45              


Ala Glu Phe Lys Glu Ala Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly 
    50                  55                  60                  


Xaa Ile Xaa Xaa Lys Glu Leu Gly Xaa Val Met Arg Ser Leu Gly Gln 
65                  70                  75                  80  


Asn Pro Xaa Glu Ala Glu Leu Gln Asp Met Ile Asn Glu Val Asp Ala 
                85                  90                  95      


Asp Gly Asn Gly Xaa Ile Asp Phe Pro Glu Phe Leu Xaa Met Met Ala 
            100                 105                 110         


Arg Lys Met Lys Asp Xaa Asp Ser Glu Glu Glu Ile Arg Glu Ala Phe 
        115                 120                 125             


Arg Val Phe Asp Lys Asp Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu 
    130                 135                 140                 


Arg His Val Met Xaa Asn Leu Gly Glu Lys Leu Xaa Asp Glu Glu Val 
145                 150                 155                 160 


Asp Glu Met Ile Arg Glu Ala Asp Ile Asp Gly Asp Gly Gln Val Asn 
                165                 170                 175     


Tyr Glu Glu Phe Val Gln Met Met Xaa Ala Lys 
            180                 185         


<210> 4785
<211> 149
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<400> 4785
Met Ala Asp Gln Leu Xaa Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala 
1               5                   10                  15      


Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Xaa Ile Xaa Xaa Lys Glu 
            20                  25                  30          


Leu Gly Xaa Val Met Arg Ser Leu Gly Gln Asn Pro Xaa Glu Ala Glu 
        35                  40                  45              


Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Xaa Ile 
    50                  55                  60                  


Asp Phe Pro Glu Phe Leu Xaa Met Met Ala Arg Lys Met Lys Asp Xaa 
65                  70                  75                  80  


Asp Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp 
                85                  90                  95      


Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Xaa Asn 
            100                 105                 110         


Leu Gly Glu Lys Leu Xaa Asp Glu Glu Val Asp Glu Met Ile Arg Glu 
        115                 120                 125             


Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln 
    130                 135                 140                 


Met Met Xaa Ala Lys 
145                 


<210> 4786
<211> 83
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 4786
Met Ala Asp Gln Leu Xaa Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala 
1               5                   10                  15      


Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Xaa Ile Xaa Xaa Lys Glu 
            20                  25                  30          


Leu Gly Xaa Val Met Arg Ser Leu Gly Gln Asn Pro Xaa Glu Ala Glu 
        35                  40                  45              


Leu Gln Asp Met Ile Asn Glu Val Asp Glu Met Ile Arg Glu Ala Asp 
    50                  55                  60                  


Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met Met 
65                  70                  75                  80  


Xaa Ala Lys 
            


<210> 4787
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 4787
Met Arg Ser Leu Gly Gln Asn Pro Xaa Glu Ala Glu Leu Gln Asp Met 
1               5                   10                  15      


Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Xaa Ile Asp Phe Pro Glu 
            20                  25                  30          


Phe Leu Xaa Met Met Ala Arg Lys Met Lys Asp Xaa Asp Ser Glu Glu 
        35                  40                  45              


Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp Gly Asn Gly Tyr 
    50                  55                  60                  


Ile Ser Ala Ala Glu Leu Arg His Val Met Xaa Asn Leu Gly Glu Lys 
65                  70                  75                  80  


Leu Xaa Asp Glu Glu Val Asp Glu Met Ile Arg Glu Ala Asp Ile Asp 
                85                  90                  95      


Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met Met Xaa Ala 
            100                 105                 110         


Lys 
    


<210> 4788
<211> 146
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<400> 4788
Met Ala Gly Glu Leu Xaa Pro Glu Glu Glu Ala Gln Tyr Lys Lys Ala 
1               5                   10                  15      


Phe Ser Ala Val Asp Xaa Asp Gly Asn Gly Xaa Ile Asn Ala Gln Glu 
            20                  25                  30          


Leu Gly Ala Ala Leu Lys Ala Xaa Gly Lys Asn Leu Ser Glu Ala Gln 
        35                  40                  45              


Leu Arg Lys Leu Ile Ser Glu Val Asp Ser Asp Gly Asp Gly Glu Ile 
    50                  55                  60                  


Ser Phe Gln Glu Phe Leu Xaa Ala Ala Lys Lys Ala Arg Ala Gly Leu 
65                  70                  75                  80  


Glu Asp Leu Gln Val Ala Phe Arg Ala Phe Asp Gln Asp Gly Asp Gly 
                85                  90                  95      


His Ile Xaa Val Asp Glu Leu Arg Arg Ala Met Ala Gly Leu Gly Gln 
            100                 105                 110         


Pro Leu Pro Gln Glu Glu Leu Asp Ala Met Ile Arg Glu Ala Asp Val 
        115                 120                 125             


Asp Gln Asp Gly Arg Val Asn Tyr Glu Glu Phe Ala Arg Met Leu Ala 
    130                 135                 140                 


Gln Glu 
145     


<210> 4789
<211> 417
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<400> 4789
Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Val 
1               5                   10                  15      


Ala Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly 
            20                  25                  30          


Trp Xaa Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
        35                  40                  45              


Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys Asp Lys 
    50                  55                  60                  


Gly Leu Gln Xaa Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Ser 
65                  70                  75                  80  


Phe Glu Pro Phe Ser Asn Lys Gly Gln Xaa Leu Val Val Gln Phe Xaa 
                85                  90                  95      


Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu 
            100                 105                 110         


Phe Pro Asn Ser Leu Asp Gln Xaa Asp Met His Gly Asp Ser Glu Tyr 
        115                 120                 125             


Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Xaa Lys Lys Val 
    130                 135                 140                 


His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp 
145                 150                 155                 160 


Ile Arg Cys Lys Asp Asp Glu Phe Xaa His Leu Tyr Xaa Leu Ile Val 
                165                 170                 175     


Arg Pro Asp Asn Xaa Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu 
            180                 185                 190         


Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile 
        195                 200                 205             


Lys Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys 
    210                 215                 220                 


Ile Asp Asp Pro Xaa Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu 
225                 230                 235                 240 


His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu 
                245                 250                 255     


Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys 
            260                 265                 270         


Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Xaa 
        275                 280                 285             


Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Pro Ser 
    290                 295                 300                 


Ile Tyr Ala Tyr Asp Asn Phe Gly Val Leu Gly Leu Asp Leu Trp Gln 
305                 310                 315                 320 


Val Lys Ser Gly Xaa Ile Phe Asp Asn Phe Leu Ile Xaa Asn Asp Glu 
                325                 330                 335     


Ala Tyr Ala Glu Glu Phe Gly Asn Glu Xaa Trp Gly Val Xaa Lys Ala 
            340                 345                 350         


Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu Lys 
        355                 360                 365             


Glu Glu Glu Glu Asp Lys Lys Arg Lys Glu Glu Glu Glu Ala Glu Asp 
    370                 375                 380                 


Lys Glu Asp Asp Glu Asp Lys Asp Glu Asp Glu Glu Asp Glu Glu Asp 
385                 390                 395                 400 


Lys Glu Glu Asp Glu Glu Glu Asp Val Pro Gly Gln Ala Lys Asp Glu 
                405                 410                 415     


Leu 
    


<210> 4790
<211> 247
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<400> 4790
Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Val 
1               5                   10                  15      


Ala Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly 
            20                  25                  30          


Trp Xaa Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
        35                  40                  45              


Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys Asp Lys 
    50                  55                  60                  


Gly Pro Asp Ile Cys Gly Pro Gly Xaa Lys Lys Val His Val Ile Phe 
65                  70                  75                  80  


Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp Ile Arg Cys Lys 
                85                  90                  95      


Asp Asp Glu Phe Xaa His Leu Tyr Xaa Leu Ile Val Arg Pro Asp Asn 
            100                 105                 110         


Xaa Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu Ser Gly Ser Leu 
        115                 120                 125             


Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile Lys Asp Pro Asp 
    130                 135                 140                 


Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys Ile Asp Asp Pro 
145                 150                 155                 160 


Xaa Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu His Ile Pro Asp 
                165                 170                 175     


Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu Met Asp Gly Glu 
            180                 185                 190         


Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys Gly Glu Trp Lys 
        195                 200                 205             


Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Xaa Trp Ile His Pro 
    210                 215                 220                 


Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Pro Ser Ile Tyr Ala Tyr 
225                 230                 235                 240 


Asp Asn Phe Gly Val Leu Gly 
                245         


<210> 4791
<211> 163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<400> 4791
Xaa Glu Asp Trp Asp Glu Arg Ala Lys Ile Asp Asp Pro Xaa Asp Ser 
1               5                   10                  15      


Lys Pro Glu Asp Trp Asp Lys Pro Glu His Ile Pro Asp Pro Asp Ala 
            20                  25                  30          


Lys Lys Pro Glu Asp Trp Asp Glu Glu Met Asp Gly Glu Trp Glu Pro 
        35                  40                  45              


Pro Val Ile Gln Asn Pro Glu Tyr Lys Gly Glu Trp Lys Pro Arg Gln 
    50                  55                  60                  


Ile Asp Asn Pro Asp Tyr Lys Gly Xaa Trp Ile His Pro Glu Ile Asp 
65                  70                  75                  80  


Asn Pro Glu Tyr Ser Pro Asp Pro Ser Ile Tyr Ala Tyr Asp Asn Phe 
                85                  90                  95      


Gly Val Leu Gly Leu Asp Leu Trp Gln Val Lys Ser Gly Xaa Ile Phe 
            100                 105                 110         


Asp Asn Phe Leu Ile Xaa Asn Asp Glu Ala Tyr Ala Glu Glu Phe Gly 
        115                 120                 125             


Asn Glu Xaa Trp Gly Val Xaa Lys Ala Ala Glu Lys Gln Met Lys Asp 
    130                 135                 140                 


Lys Gln Asp Glu Glu Gln Arg Pro Glu Arg Ser Cys Arg Arg Ala Gly 
145                 150                 155                 160 


Arg Ala Lys 
            


<210> 4792
<211> 13
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 4792
Xaa Glu Glu Asp Val Pro Gly Gln Ala Lys Asp Glu Leu 
1               5                   10              


<210> 4793
<211> 124
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<400> 4793
Met Val Lys Leu Gly Cys Ser Phe Ser Gly Lys Pro Gly Lys Asp Pro 
1               5                   10                  15      


Gly Asp Gln Asp Gly Ala Ala Met Asp Ser Val Pro Leu Ile Ser Pro 
            20                  25                  30          


Leu Asp Ile Ser Gln Leu Gln Pro Pro Leu Pro Asp Gln Val Val Ile 
        35                  40                  45              


Lys Xaa Gln Xaa Glu Tyr Gln Leu Ser Ser Pro Asp Gln Gln Asn Phe 
    50                  55                  60                  


Pro Asp Leu Glu Gly Gln Arg Leu Asn Cys Ser His Pro Glu Glu Gly 
65                  70                  75                  80  


Arg Arg Leu Pro Xaa Ala Arg Met Ile Ala Phe Ala Met Ala Leu Leu 
                85                  90                  95      


Gly Cys Val Leu Ile Met Tyr Lys Ala Ile Trp Tyr Asp Gln Phe Xaa 
            100                 105                 110         


Cys Pro Asp Gly Phe Leu Leu Arg Gly Pro Glu Phe 
        115                 120                 


<210> 4794
<211> 217
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<400> 4794
Met Val Lys Leu Gly Cys Ser Phe Ser Gly Lys Pro Gly Lys Asp Pro 
1               5                   10                  15      


Gly Asp Gln Asp Gly Ala Ala Met Asp Ser Val Pro Leu Ile Ser Pro 
            20                  25                  30          


Leu Asp Ile Ser Gln Leu Gln Pro Pro Leu Pro Asp Gln Val Val Ile 
        35                  40                  45              


Lys Xaa Gln Xaa Glu Tyr Gln Leu Ser Ser Pro Asp Gln Gln Asn Phe 
    50                  55                  60                  


Pro Asp Leu Glu Gly Gln Arg Leu Asn Cys Ser His Pro Glu Glu Gly 
65                  70                  75                  80  


Arg Arg Leu Pro Xaa Ala Arg Met Ile Ala Phe Ala Met Ala Leu Leu 
                85                  90                  95      


Gly Cys Val Leu Ile Met Tyr Lys Ala Ile Trp Tyr Asp Gln Phe Xaa 
            100                 105                 110         


Cys Pro Asp Gly Phe Leu Leu Arg His Lys Ile Cys Xaa Pro Leu Xaa 
        115                 120                 125             


Leu Glu Met Tyr Tyr Xaa Glu Met Asp Pro Glu Arg His Arg Ser Ile 
    130                 135                 140                 


Leu Ala Ala Ile Gly Ala Tyr Pro Leu Ser Arg Lys His Gly Xaa Glu 
145                 150                 155                 160 


Xaa Pro Ala Ala Trp Gly Asp Gly Tyr Arg Ala Ala Lys Glu Glu Arg 
                165                 170                 175     


Lys Gly Pro Xaa Gln Ala Gly Ala Ala Ala Ala Ala Xaa Glu Pro Pro 
            180                 185                 190         


Gly Lys Pro Ser Ala Lys Ala Glu Lys Glu Ala Ala Arg Lys Ala Ala 
        195                 200                 205             


Gly Ser Ala Ala Pro Pro Pro Ala Gln 
    210                 215         


<210> 4795
<211> 158
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<400> 4795
Met Val Lys Leu Gly Cys Ser Phe Ser Gly Lys Pro Gly Lys Asp Pro 
1               5                   10                  15      


Gly Asp Gln Asp Gly Ala Ala Met Asp Ser Val Pro Leu Ile Ser Pro 
            20                  25                  30          


Leu Asp Ile Ser Gln Leu Gln Pro Pro Leu Pro Asp Gln Val Val Ile 
        35                  40                  45              


Lys Xaa Gln Xaa Glu Tyr Gln Leu Ser Ser Pro Asp Gln Gln Asn Phe 
    50                  55                  60                  


Pro Asp Leu Glu Gly Gln Arg Leu Asn Cys Ser His Pro Glu Glu Gly 
65                  70                  75                  80  


Arg Arg Val Xaa Xaa Pro Xaa Pro Pro Xaa Val Gly Xaa Gln Asp Arg 
                85                  90                  95      


Arg Arg Arg Trp Lys Ala Ala Gly Gly Ala Trp Val Pro Ser Arg Pro 
            100                 105                 110         


Val Trp Gly Pro Leu Ala Leu Arg Glu Glu Arg Val Ala Val Ser His 
        115                 120                 125             


Pro Ala Gln Ser Trp Pro His Arg Leu Pro Cys Xaa His Gln Ala Pro 
    130                 135                 140                 


Ser Arg Gly Cys Arg Cys Arg Leu Xaa Lys Gln Trp Arg Ser 
145                 150                 155             


<210> 4796
<211> 370
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<400> 4796
Met Leu Gly Ala Val Glu Gly Pro Arg Trp Lys Gln Ala Glu Asp Ile 
1               5                   10                  15      


Arg Asp Ile Tyr Asp Phe Arg Asp Val Leu Gly Xaa Gly Ala Phe Ser 
            20                  25                  30          


Glu Val Ile Leu Ala Glu Asp Lys Arg Xaa Gln Lys Leu Val Ala Ile 
        35                  40                  45              


Lys Cys Ile Ala Lys Glu Ala Leu Glu Gly Lys Glu Gly Ser Met Glu 
    50                  55                  60                  


Asn Glu Ile Ala Val Leu His Lys Ile Lys His Pro Asn Ile Val Ala 
65                  70                  75                  80  


Leu Asp Asp Ile Tyr Glu Ser Gly Gly His Leu Tyr Leu Ile Met Gln 
                85                  90                  95      


Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Val Glu Lys Gly Phe 
            100                 105                 110         


Tyr Xaa Glu Arg Asp Ala Ser Arg Leu Ile Phe Gln Val Leu Asp Ala 
        115                 120                 125             


Val Lys Tyr Leu His Asp Leu Gly Ile Val His Arg Asp Leu Lys Pro 
    130                 135                 140                 


Glu Asn Leu Leu Tyr Tyr Ser Leu Asp Glu Asp Ser Lys Ile Met Ile 
145                 150                 155                 160 


Ser Asp Phe Gly Leu Ser Lys Met Glu Asp Pro Gly Ser Val Leu Ser 
                165                 170                 175     


Xaa Ala Cys Gly Xaa Pro Gly Tyr Val Ala Pro Glu Val Leu Ala Gln 
            180                 185                 190         


Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly Val Ile Ala 
        195                 200                 205             


Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Asp Glu Asn Asp Ala 
    210                 215                 220                 


Lys Leu Phe Glu Gln Ile Leu Lys Ala Glu Tyr Glu Phe Asp Ser Pro 
225                 230                 235                 240 


Tyr Trp Asp Asp Ile Ser Asp Ser Ala Lys Asp Phe Ile Arg His Leu 
                245                 250                 255     


Met Glu Lys Asp Pro Glu Lys Arg Phe Xaa Cys Glu Gln Ala Leu Gln 
            260                 265                 270         


His Pro Trp Ile Ala Gly Asp Xaa Ala Leu Asp Lys Asn Ile His Gln 
        275                 280                 285             


Ser Val Ser Glu Gln Ile Lys Lys Asn Phe Ala Lys Ser Lys Trp Lys 
    290                 295                 300                 


Gln Ala Phe Asn Ala Xaa Ala Val Val Arg His Met Arg Lys Leu Gln 
305                 310                 315                 320 


Leu Gly Xaa Ser Gln Glu Gly Gln Gly Gln Xaa Ala Ser His Gly Glu 
                325                 330                 335     


Leu Leu Xaa Pro Val Ala Gly Gly Pro Ala Ala Gly Cys Cys Cys Arg 
            340                 345                 350         


Asp Cys Cys Val Glu Pro Gly Xaa Glu Leu Ser Pro Xaa Leu Pro His 
        355                 360                 365             


Gln Leu 
    370 


<210> 4797
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<400> 4797
Met Leu Gly Ala Val Glu Gly Pro Arg Trp Lys Gln Ala Glu Asp Ile 
1               5                   10                  15      


Arg Asp Ile Tyr Asp Phe Arg Asp Val Leu Gly Xaa Ile Lys His Pro 
            20                  25                  30          


Asn Ile Val Ala Leu Asp Asp Ile Tyr Glu Ser Gly Gly His Leu Tyr 
        35                  40                  45              


Leu Ile Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Val 
    50                  55                  60                  


Glu Lys Gly Phe Tyr Xaa Glu Arg Asp Ala Ser Arg Leu Ile Phe Gln 
65                  70                  75                  80  


Val Leu Asp Ala Val Lys Tyr Leu His Asp Leu Gly Ile Val His Arg 
                85                  90                  95      


Asp Leu Lys Pro Glu Asn Leu Leu Tyr Tyr Ser Leu Asp Glu Asp Ser 
            100                 105                 110         


Lys Ile Met Ile Ser Asp Phe Gly Leu Ser 
        115                 120         


<210> 4798
<211> 39
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<400> 4798
Met Leu Gly Ala Val Glu Gly Pro Arg Trp Lys Gln Ala Glu Asp Ile 
1               5                   10                  15      


Arg Asp Ile Tyr Asp Phe Arg Asp Val Leu Gly Xaa Leu Ser Pro Gly 
            20                  25                  30          


Gly Gly Lys Asp Asp Arg His 
        35                  


<210> 4799
<211> 260
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<400> 4799
Xaa Asp Ser Lys Ile Met Ile Ser Asp Phe Gly Leu Ser Lys Met Glu 
1               5                   10                  15      


Asp Pro Gly Ser Val Leu Ser Xaa Ala Cys Gly Xaa Pro Gly Tyr Val 
            20                  25                  30          


Ala Pro Glu Val Leu Ala Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys 
        35                  40                  45              


Trp Ser Ile Gly Val Ile Ala Tyr Ile Leu Leu Cys Gly Tyr Pro Pro 
    50                  55                  60                  


Phe Tyr Asp Glu Asn Asp Ala Lys Leu Phe Glu Gln Ile Leu Lys Ala 
65                  70                  75                  80  


Glu Tyr Glu Phe Asp Ser Pro Tyr Trp Asp Asp Ile Ser Asp Ser Ala 
                85                  90                  95      


Lys Asp Phe Ile Arg His Leu Met Glu Lys Asp Pro Glu Lys Arg Phe 
            100                 105                 110         


Xaa Cys Glu Gln Ala Leu Gln His Pro Trp Ile Ala Gly Asp Xaa Ala 
        115                 120                 125             


Leu Asp Lys Asn Ile His Gln Ser Val Ser Glu Gln Ile Lys Lys Asn 
    130                 135                 140                 


Phe Ala Lys Ser Lys Trp Lys Gln Ala Phe Asn Ala Xaa Ala Val Val 
145                 150                 155                 160 


Arg His Met Arg Lys Leu Gln Leu Gly Xaa Ser Gln Glu Gly Gln Gly 
                165                 170                 175     


Gln Xaa Ala Ser His Gly Glu Leu Leu Xaa Pro Val Ala Gly Gly Glu 
            180                 185                 190         


Glu Arg Ala Leu Gln Lys Gly Met Gly Gly Pro Gln Arg Cys Xaa Arg 
        195                 200                 205             


Ala Gly Val Glu Gly Leu Pro Leu Arg Pro Pro Leu Phe Cys Leu Pro 
    210                 215                 220                 


Met Gln Gly Arg Gln Leu Ala Val Ala Val Glu Xaa Ala Ala Trp Ser 
225                 230                 235                 240 


Arg Ala Gln Asn Cys Pro Pro His Cys Pro Xaa Ser Ser Arg Ala Leu 
                245                 250                 255     


Asp Leu Gly Ser 
            260 


<210> 4800
<211> 357
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<400> 4800
Met Ala Arg Glu Asn Gly Glu Ser Ser Ser Ser Trp Lys Lys Gln Ala 
1               5                   10                  15      


Glu Asp Ile Lys Lys Ile Phe Glu Phe Lys Glu Xaa Leu Gly Xaa Gly 
            20                  25                  30          


Ala Phe Ser Glu Val Val Leu Ala Glu Glu Lys Ala Xaa Gly Lys Leu 
        35                  40                  45              


Phe Ala Val Lys Cys Ile Pro Lys Lys Ala Leu Lys Gly Lys Glu Ser 
    50                  55                  60                  


Ser Ile Glu Asn Glu Ile Ala Val Leu Arg Lys Ile Lys His Glu Asn 
65                  70                  75                  80  


Ile Val Ala Leu Glu Asp Ile Tyr Glu Ser Pro Asn His Leu Tyr Leu 
                85                  90                  95      


Val Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Val Glu 
            100                 105                 110         


Lys Gly Phe Tyr Xaa Glu Lys Asp Ala Ser Xaa Leu Ile Arg Gln Val 
        115                 120                 125             


Leu Asp Ala Val Tyr Tyr Leu His Arg Met Gly Ile Val His Arg Asp 
    130                 135                 140                 


Leu Lys Pro Glu Asn Leu Leu Tyr Tyr Ser Gln Asp Glu Glu Ser Lys 
145                 150                 155                 160 


Ile Met Ile Ser Asp Phe Gly Leu Ser Lys Met Glu Gly Lys Gly Asp 
                165                 170                 175     


Val Met Ser Xaa Ala Cys Gly Xaa Pro Gly Tyr Val Ala Pro Glu Val 
            180                 185                 190         


Leu Ala Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly 
        195                 200                 205             


Val Ile Ala Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Asp Glu 
    210                 215                 220                 


Asn Asp Ser Lys Leu Phe Glu Gln Ile Leu Lys Ala Glu Tyr Glu Phe 
225                 230                 235                 240 


Asp Ser Pro Tyr Trp Asp Asp Ile Ser Asp Ser Ala Lys Asp Phe Ile 
                245                 250                 255     


Arg Asn Leu Met Glu Lys Asp Pro Asn Lys Arg Tyr Xaa Cys Glu Gln 
            260                 265                 270         


Ala Ala Arg His Pro Trp Ile Ala Gly Asp Xaa Ala Leu Asn Lys Asn 
        275                 280                 285             


Ile His Glu Ser Val Ser Ala Gln Ile Arg Lys Asn Phe Ala Lys Ser 
    290                 295                 300                 


Lys Trp Arg Gln Ala Phe Asn Ala Xaa Ala Val Val Arg His Met Arg 
305                 310                 315                 320 


Lys Leu His Leu Gly Ser Ser Leu Asp Ser Ser Asn Ala Ser Val Ser 
                325                 330                 335     


Ser Ser Leu Ser Leu Ala Ser Gln Lys Asp Cys Ala Tyr Val Ala Lys 
            340                 345                 350         


Pro Glu Ser Leu Ser 
        355         


<210> 4801
<211> 385
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<400> 4801
Met Ala Arg Glu Asn Gly Glu Ser Ser Ser Ser Trp Lys Lys Gln Ala 
1               5                   10                  15      


Glu Asp Ile Lys Lys Ile Phe Glu Phe Lys Glu Xaa Leu Gly Xaa Gly 
            20                  25                  30          


Ala Phe Ser Glu Val Val Leu Ala Glu Glu Lys Ala Xaa Gly Lys Leu 
        35                  40                  45              


Phe Ala Val Lys Cys Ile Pro Lys Lys Ala Leu Lys Gly Lys Glu Ser 
    50                  55                  60                  


Ser Ile Glu Asn Glu Ile Ala Val Leu Arg Lys Ile Lys His Glu Asn 
65                  70                  75                  80  


Ile Val Ala Leu Glu Asp Ile Tyr Glu Ser Pro Asn His Leu Tyr Leu 
                85                  90                  95      


Val Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Val Glu 
            100                 105                 110         


Lys Gly Phe Tyr Xaa Glu Lys Asp Ala Ser Xaa Leu Ile Arg Gln Val 
        115                 120                 125             


Leu Asp Ala Val Tyr Tyr Leu His Arg Met Gly Ile Val His Arg Asp 
    130                 135                 140                 


Leu Lys Pro Glu Asn Leu Leu Tyr Tyr Ser Gln Asp Glu Glu Ser Lys 
145                 150                 155                 160 


Ile Met Ile Ser Asp Phe Gly Leu Ser Lys Met Glu Gly Lys Gly Asp 
                165                 170                 175     


Val Met Ser Xaa Ala Cys Gly Xaa Pro Gly Tyr Val Ala Pro Glu Val 
            180                 185                 190         


Leu Ala Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly 
        195                 200                 205             


Val Ile Ala Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Asp Glu 
    210                 215                 220                 


Asn Asp Ser Lys Leu Phe Glu Gln Ile Leu Lys Ala Glu Tyr Glu Phe 
225                 230                 235                 240 


Asp Ser Pro Tyr Trp Asp Asp Ile Ser Asp Ser Ala Lys Asp Phe Ile 
                245                 250                 255     


Arg Asn Leu Met Glu Lys Asp Pro Asn Lys Arg Tyr Xaa Cys Glu Gln 
            260                 265                 270         


Ala Ala Arg His Pro Trp Ile Ala Gly Asp Xaa Ala Leu Asn Lys Asn 
        275                 280                 285             


Ile His Glu Ser Val Ser Ala Gln Ile Arg Lys Asn Phe Ala Lys Ser 
    290                 295                 300                 


Lys Trp Arg Gln Ala Phe Asn Ala Xaa Ala Val Val Arg His Met Arg 
305                 310                 315                 320 


Lys Leu His Leu Gly Ser Ser Leu Asp Ser Ser Asn Ala Ser Val Ser 
                325                 330                 335     


Ser Ser Leu Ser Leu Ala Ser Gln Lys Asp Cys Leu Ala Pro Ser Xaa 
            340                 345                 350         


Leu Cys Ser Phe Ile Ser Ser Ser Ser Gly Val Ser Gly Val Gly Ala 
        355                 360                 365             


Glu Arg Arg Pro Arg Pro Xaa Xaa Val Xaa Ala Val His Ser Gly Ser 
    370                 375                 380                 


Lys 
385 


<210> 4802
<211> 291
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<400> 4802
Tyr Cys Leu Met Gln Arg Val Ser Gly Gly Glu Leu Phe Asp Arg Ile 
1               5                   10                  15      


Val Glu Lys Gly Phe Tyr Xaa Glu Lys Asp Ala Ser Xaa Leu Ile Arg 
            20                  25                  30          


Gln Val Leu Asp Ala Val Tyr Tyr Leu His Arg Met Gly Ile Val His 
        35                  40                  45              


Arg Asp Leu Lys Pro Glu Asn Leu Leu Tyr Tyr Ser Gln Asp Glu Glu 
    50                  55                  60                  


Ser Lys Ile Met Ile Ser Asp Phe Gly Leu Ser Lys Met Glu Gly Lys 
65                  70                  75                  80  


Gly Asp Val Met Ser Xaa Ala Cys Gly Xaa Pro Gly Tyr Val Ala Pro 
                85                  90                  95      


Glu Val Leu Ala Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser 
            100                 105                 110         


Ile Gly Val Ile Ala Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr 
        115                 120                 125             


Asp Glu Asn Asp Ser Lys Leu Phe Glu Gln Ile Leu Lys Ala Glu Tyr 
    130                 135                 140                 


Glu Phe Asp Ser Pro Tyr Trp Asp Asp Ile Ser Asp Ser Ala Lys Asp 
145                 150                 155                 160 


Phe Ile Arg Asn Leu Met Glu Lys Asp Pro Asn Lys Arg Tyr Xaa Cys 
                165                 170                 175     


Glu Gln Ala Ala Arg His Pro Trp Ile Ala Gly Asp Xaa Ala Leu Asn 
            180                 185                 190         


Lys Asn Ile His Glu Ser Val Ser Ala Gln Ile Arg Lys Asn Phe Ala 
        195                 200                 205             


Lys Ser Lys Trp Arg Gln Ala Phe Asn Ala Xaa Ala Val Val Arg His 
    210                 215                 220                 


Met Arg Lys Leu His Leu Gly Ser Ser Leu Asp Ser Ser Asn Ala Ser 
225                 230                 235                 240 


Val Ser Ser Ser Leu Ser Leu Ala Ser Gln Lys Asp Cys Leu Ala Pro 
                245                 250                 255     


Ser Xaa Leu Cys Ser Phe Ile Ser Ser Ser Ser Gly Val Ser Gly Val 
            260                 265                 270         


Gly Ala Glu Arg Arg Pro Arg Pro Xaa Xaa Val Xaa Ala Val His Ser 
        275                 280                 285             


Gly Ser Lys 
    290     


<210> 4803
<211> 91
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<400> 4803
Met Ala Xaa Ile Xaa Cys Xaa Arg Phe Xaa Glu Glu Tyr Gln Leu Phe 
1               5                   10                  15      


Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val Lys 
            20                  25                  30          


Val Leu Ala Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys Lys 
        35                  40                  45              


Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile Cys 
    50                  55                  60                  


Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile Ser 
65                  70                  75                  80  


Glu Glu Gly His His Tyr Leu Ile Phe Asp Leu 
                85                  90      


<210> 4804
<211> 478
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<400> 4804
Met Ala Xaa Ile Xaa Cys Xaa Arg Phe Xaa Glu Glu Tyr Gln Leu Phe 
1               5                   10                  15      


Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val Lys 
            20                  25                  30          


Val Leu Ala Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys Lys 
        35                  40                  45              


Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile Cys 
    50                  55                  60                  


Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile Ser 
65                  70                  75                  80  


Glu Glu Gly His His Tyr Leu Ile Phe Asp Leu Val Xaa Gly Gly Glu 
                85                  90                  95      


Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp Ala 
            100                 105                 110         


Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His Gln 
        115                 120                 125             


Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu Ala 
    130                 135                 140                 


Ser Lys Leu Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu Ala 
145                 150                 155                 160 


Ile Glu Val Glu Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly Xaa 
                165                 170                 175     


Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly Lys 
            180                 185                 190         


Pro Val Asp Leu Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu Val 
        195                 200                 205             


Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln Gln 
    210                 215                 220                 


Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa Val 
225                 230                 235                 240 


Xaa Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Xaa Ile Asn Pro 
                245                 250                 255     


Ser Lys Arg Ile Xaa Ala Ala Glu Ala Leu Lys His Pro Trp Ile Ser 
            260                 265                 270         


His Arg Ser Xaa Val Ala Ser Cys Met His Arg Gln Glu Xaa Val Asp 
        275                 280                 285             


Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile Leu 
    290                 295                 300                 


Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Gly Gly Lys Ser Gly Gly 
305                 310                 315                 320 


Asn Lys Lys Ser Asp Gly Val Lys Glu Ser Ser Glu Ser Xaa Asn Xaa 
                325                 330                 335     


Xaa Ile Glu Asp Glu Asp Xaa Lys Val Arg Lys Gln Glu Ile Ile Lys 
            340                 345                 350         


Val Xaa Glu Gln Leu Ile Glu Ala Ile Ser Asn Gly Asp Phe Glu Ser 
        355                 360                 365             


Tyr Xaa Lys Met Cys Asp Pro Gly Met Xaa Ala Phe Glu Pro Glu Ala 
    370                 375                 380                 


Leu Gly Asn Leu Val Glu Gly Leu Asp Phe His Arg Phe Tyr Phe Glu 
385                 390                 395                 400 


Asn Leu Trp Ser Arg Asn Ser Lys Pro Val His Xaa Xaa Ile Leu Asn 
                405                 410                 415     


Pro His Ile His Leu Met Gly Asp Glu Ser Ala Cys Ile Ala Tyr Ile 
            420                 425                 430         


Arg Ile Xaa Gln Tyr Leu Asp Ala Gly Gly Ile Pro Arg Xaa Ala Gln 
        435                 440                 445             


Ser Glu Glu Xaa Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Ile 
    450                 455                 460                 


Val His Phe His Arg Ser Gly Ala Pro Ser Val Leu Pro His 
465                 470                 475             


<210> 4805
<211> 489
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<400> 4805
Met Ala Xaa Ile Xaa Cys Xaa Arg Phe Xaa Glu Glu Tyr Gln Leu Phe 
1               5                   10                  15      


Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val Lys 
            20                  25                  30          


Val Leu Ala Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys Lys 
        35                  40                  45              


Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile Cys 
    50                  55                  60                  


Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile Ser 
65                  70                  75                  80  


Glu Glu Gly His His Tyr Leu Ile Phe Asp Leu Val Xaa Gly Gly Glu 
                85                  90                  95      


Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp Ala 
            100                 105                 110         


Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His Gln 
        115                 120                 125             


Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu Ala 
    130                 135                 140                 


Ser Lys Leu Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu Ala 
145                 150                 155                 160 


Ile Glu Val Glu Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly Xaa 
                165                 170                 175     


Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly Lys 
            180                 185                 190         


Pro Val Asp Leu Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu Val 
        195                 200                 205             


Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln Gln 
    210                 215                 220                 


Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa Val 
225                 230                 235                 240 


Xaa Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Xaa Ile Asn Pro 
                245                 250                 255     


Ser Lys Arg Ile Xaa Ala Ala Glu Ala Leu Lys His Pro Trp Ile Ser 
            260                 265                 270         


His Arg Ser Xaa Val Ala Ser Cys Met His Arg Gln Glu Xaa Val Asp 
        275                 280                 285             


Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile Leu 
    290                 295                 300                 


Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Gly Gly Lys Ser Gly Gly 
305                 310                 315                 320 


Asn Lys Lys Ser Asp Gly Val Lys Lys Arg Lys Ser Ser Ser Ser Val 
                325                 330                 335     


Gln Leu Met Glu Ser Ser Glu Ser Xaa Asn Xaa Xaa Ile Glu Asp Glu 
            340                 345                 350         


Asp Xaa Lys Val Arg Lys Gln Glu Ile Ile Lys Val Xaa Glu Gln Leu 
        355                 360                 365             


Ile Glu Ala Ile Ser Asn Gly Asp Phe Glu Ser Tyr Xaa Lys Met Cys 
    370                 375                 380                 


Asp Pro Gly Met Xaa Ala Phe Glu Pro Glu Ala Leu Gly Asn Leu Val 
385                 390                 395                 400 


Glu Gly Leu Asp Phe His Arg Phe Tyr Phe Glu Asn Leu Trp Ser Arg 
                405                 410                 415     


Asn Ser Lys Pro Val His Xaa Xaa Ile Leu Asn Pro His Ile His Leu 
            420                 425                 430         


Met Gly Asp Glu Ser Ala Cys Ile Ala Tyr Ile Arg Ile Xaa Gln Tyr 
        435                 440                 445             


Leu Asp Ala Gly Gly Ile Pro Arg Xaa Ala Gln Ser Glu Glu Xaa Arg 
    450                 455                 460                 


Val Trp His Arg Arg Asp Gly Lys Trp Gln Ile Val His Phe His Arg 
465                 470                 475                 480 


Ser Gly Ala Pro Ser Val Leu Pro His 
                485                 


<210> 4806
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4806
Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu Ala 
1               5                   10                  15      


Ser Lys Leu Lys Gly Ala Ala Val 
            20                  


<210> 4807
<211> 184
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<400> 4807
Leu Pro Ala Val Ser Leu Xaa Gly Met Asp Asp Ile Pro Gly Leu Leu 
1               5                   10                  15      


Pro Pro Pro Pro Val Gly Arg His Gln Xaa Gly Gly Gly Val Glu Ile 
            20                  25                  30          


Leu Leu Glu Lys Arg Leu Leu Gly His Gly Leu Gly Met Ala Gly Gln 
        35                  40                  45              


Trp Leu Ala Arg Lys Gln Glu Ile Ile Lys Xaa Xaa Glu Gln Leu Ile 
    50                  55                  60                  


Glu Ala Val Asn Asn Gly Asp Phe Glu Ala Tyr Ala Lys Ile Cys Asp 
65                  70                  75                  80  


Pro Gly Leu Xaa Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu Val Glu 
                85                  90                  95      


Gly Met Asp Phe His Arg Phe Tyr Phe Glu Asn Leu Leu Ala Lys Asn 
            100                 105                 110         


Ser Lys Pro Ile His Xaa Xaa Ile Leu Asn Pro His Val His Val Ile 
        115                 120                 125             


Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Xaa Gln Tyr Ile 
    130                 135                 140                 


Asp Gly Gln Gly Arg Pro Arg Xaa Ser Gln Ser Glu Glu Xaa Arg Val 
145                 150                 155                 160 


Trp His Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His Cys Ser 
                165                 170                 175     


Gly Ala Pro Val Ala Pro Leu Gln 
            180                 


<210> 4808
<211> 168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<400> 4808
Met Ala Xaa Xaa Val Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Xaa Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Arg Ala Xaa Arg Xaa Asn Pro Pro Ala Val Cys His Ser His Cys 
        115                 120                 125             


Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His Gln Met Gly Val 
    130                 135                 140                 


Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu Ala Ser Lys Cys 
145                 150                 155                 160 


Lys Gly Ala Ala Val Lys Leu Ala 
                165             


<210> 4809
<211> 180
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<400> 4809
Met Ala Xaa Xaa Val Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Xaa Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Leu His Gly Glu Leu Gly 
    130                 135                 140                 


Ala Ser Xaa His Ser Arg Trp Gln Asn His His Val Gln Trp Pro Val 
145                 150                 155                 160 


Asp Trp Cys Ser Val Asp Xaa Asp Ala Cys Ala Pro Ala Gly Trp Asp 
                165                 170                 175     


Pro Gln Gly Asp 
            180 


<210> 4810
<211> 362
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<400> 4810
Met Ala Xaa Xaa Val Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Xaa Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Pro Arg Val 
    290                 295                 300                 


Tyr Ser Xaa Arg Lys Gln Met Glu Ser Ser Pro Arg Arg Ile Ala Pro 
305                 310                 315                 320 


Lys Xaa Val Gln Pro Pro Pro Ala Pro Lys Gly Arg Phe Leu Leu Pro 
                325                 330                 335     


Pro Trp Ser Leu Lys Pro Pro Ser Ser Ile Xaa Gln Trp Xaa Gly Leu 
            340                 345                 350         


Arg Ser Leu Leu Xaa Val Pro Ile Pro Pro 
        355                 360         


<210> 4811
<211> 449
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<400> 4811
Met Ala Xaa Xaa Val Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Xaa Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Ala Arg Lys Gln Glu 
305                 310                 315                 320 


Ile Ile Lys Xaa Xaa Glu Gln Leu Ile Glu Ala Val Asn Asn Gly Asp 
                325                 330                 335     


Phe Glu Ala Tyr Ala Lys Ile Cys Asp Pro Gly Leu Xaa Ser Phe Glu 
            340                 345                 350         


Pro Glu Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe 
        355                 360                 365             


Tyr Phe Glu Asn Leu Leu Ala Lys Asn Ser Lys Pro Ile His Xaa Xaa 
    370                 375                 380                 


Ile Leu Asn Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile 
385                 390                 395                 400 


Ala Tyr Ile Arg Leu Xaa Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg 
                405                 410                 415     


Xaa Ser Gln Ser Glu Glu Xaa Arg Val Trp His Arg Arg Asp Gly Lys 
            420                 425                 430         


Trp Gln Asn Val His Phe His Cys Ser Gly Ala Pro Val Ala Pro Leu 
        435                 440                 445             


Gln 
    


<210> 4812
<211> 479
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<400> 4812
Met Ala Xaa Xaa Val Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Xaa Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Asn Lys Lys Ala Asp Gly Val Lys Glu Ser Ser Asp Ser Ala Asn 
                325                 330                 335     


Xaa Xaa Ile Glu Asp Glu Asp Ala Lys Ala Arg Lys Gln Glu Ile Ile 
            340                 345                 350         


Lys Xaa Xaa Glu Gln Leu Ile Glu Ala Val Asn Asn Gly Asp Phe Glu 
        355                 360                 365             


Ala Tyr Ala Lys Ile Cys Asp Pro Gly Leu Xaa Ser Phe Glu Pro Glu 
    370                 375                 380                 


Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe 
385                 390                 395                 400 


Glu Asn Leu Leu Ala Lys Asn Ser Lys Pro Ile His Xaa Xaa Ile Leu 
                405                 410                 415     


Asn Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr 
            420                 425                 430         


Ile Arg Leu Xaa Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Xaa Ser 
        435                 440                 445             


Gln Ser Glu Glu Xaa Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln 
    450                 455                 460                 


Asn Val His Phe His Cys Ser Gly Ala Pro Val Ala Pro Leu Gln 
465                 470                 475                 


<210> 4813
<211> 492
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<400> 4813
Met Ala Xaa Xaa Val Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Xaa Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Val Gly Arg Gln Xaa 
305                 310                 315                 320 


Xaa Ala Pro Ala Xaa Met Ser Xaa Ala Ala Ser Gly Xaa Xaa Met Gly 
                325                 330                 335     


Leu Val Glu Gln Ala Lys Ser Leu Leu Asn Lys Lys Ala Asp Gly Val 
            340                 345                 350         


Lys Glu Pro Gln Xaa Xaa Val Ile His Asn Pro Val Asp Gly Ile Lys 
        355                 360                 365             


Glu Ser Ser Asp Ser Ala Asn Xaa Xaa Ile Glu Asp Glu Asp Ala Lys 
    370                 375                 380                 


Ala Arg Lys Gln Glu Ile Ile Lys Xaa Xaa Glu Gln Leu Ile Glu Ala 
385                 390                 395                 400 


Val Asn Asn Gly Asp Phe Glu Ala Tyr Ala Phe Tyr Phe Glu Asn Leu 
                405                 410                 415     


Leu Ala Lys Asn Ser Lys Pro Ile His Xaa Xaa Ile Leu Asn Pro His 
            420                 425                 430         


Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu 
        435                 440                 445             


Xaa Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Xaa Ser Gln Ser Glu 
    450                 455                 460                 


Glu Xaa Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn Val His 
465                 470                 475                 480 


Phe His Cys Ser Gly Ala Pro Val Ala Pro Leu Gln 
                485                 490         


<210> 4814
<211> 503
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<400> 4814
Met Ala Xaa Xaa Val Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Xaa Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Asn Lys Lys Ala Asp Gly Val Lys Pro Gln Xaa Asn Ser Xaa Lys 
                325                 330                 335     


Asn Ser Ala Ala Ala Xaa Ser Pro Lys Gly Xaa Leu Pro Pro Ala Ala 
            340                 345                 350         


Leu Glu Ser Ser Asp Ser Ala Asn Xaa Xaa Ile Glu Asp Glu Asp Ala 
        355                 360                 365             


Lys Ala Arg Lys Gln Glu Ile Ile Lys Xaa Xaa Glu Gln Leu Ile Glu 
    370                 375                 380                 


Ala Val Asn Asn Gly Asp Phe Glu Ala Tyr Ala Lys Ile Cys Asp Pro 
385                 390                 395                 400 


Gly Leu Xaa Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu Val Glu Gly 
                405                 410                 415     


Met Asp Phe His Arg Phe Tyr Phe Glu Asn Leu Leu Ala Lys Asn Ser 
            420                 425                 430         


Lys Pro Ile His Xaa Xaa Ile Leu Asn Pro His Val His Val Ile Gly 
        435                 440                 445             


Glu Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Xaa Gln Tyr Ile Asp 
    450                 455                 460                 


Gly Gln Gly Arg Pro Arg Xaa Ser Gln Ser Glu Glu Xaa Arg Val Trp 
465                 470                 475                 480 


His Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His Cys Ser Gly 
                485                 490                 495     


Ala Pro Val Ala Pro Leu Gln 
            500             


<210> 4815
<211> 517
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<400> 4815
Met Ala Xaa Xaa Val Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Xaa Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Ala Lys Ser Leu Leu 
305                 310                 315                 320 


Asn Lys Lys Ala Asp Gly Val Lys Pro Gln Xaa Asn Ser Xaa Lys Asn 
                325                 330                 335     


Ser Ala Ala Ala Xaa Ser Pro Lys Gly Xaa Leu Pro Pro Ala Ala Leu 
            340                 345                 350         


Glu Pro Gln Xaa Xaa Val Ile His Asn Pro Val Asp Gly Ile Lys Glu 
        355                 360                 365             


Ser Ser Asp Ser Ala Asn Xaa Xaa Ile Glu Asp Glu Asp Ala Lys Ala 
    370                 375                 380                 


Arg Lys Gln Glu Ile Ile Lys Xaa Xaa Glu Gln Leu Ile Glu Ala Val 
385                 390                 395                 400 


Asn Asn Gly Asp Phe Glu Ala Tyr Ala Lys Ile Cys Asp Pro Gly Leu 
                405                 410                 415     


Xaa Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu Val Glu Gly Met Asp 
            420                 425                 430         


Phe His Arg Phe Tyr Phe Glu Asn Leu Leu Ala Lys Asn Ser Lys Pro 
        435                 440                 445             


Ile His Xaa Xaa Ile Leu Asn Pro His Val His Val Ile Gly Glu Asp 
    450                 455                 460                 


Ala Ala Cys Ile Ala Tyr Ile Arg Leu Xaa Gln Tyr Ile Asp Gly Gln 
465                 470                 475                 480 


Gly Arg Pro Arg Xaa Ser Gln Ser Glu Glu Xaa Arg Val Trp His Arg 
                485                 490                 495     


Arg Asp Gly Lys Trp Gln Asn Val His Phe His Cys Ser Gly Ala Pro 
            500                 505                 510         


Val Ala Pro Leu Gln 
        515         


<210> 4816
<211> 518
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<400> 4816
Met Ala Xaa Xaa Val Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Xaa Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Asn Lys Lys Ala Asp Gly Val Lys Pro Gln Xaa Asn Ser Xaa Lys 
                325                 330                 335     


Asn Ser Ala Ala Ala Xaa Ser Pro Lys Gly Xaa Leu Pro Pro Ala Ala 
            340                 345                 350         


Leu Glu Pro Gln Xaa Xaa Val Ile His Asn Pro Val Asp Gly Ile Lys 
        355                 360                 365             


Glu Ser Ser Asp Ser Ala Asn Xaa Xaa Ile Glu Asp Glu Asp Ala Lys 
    370                 375                 380                 


Ala Arg Lys Gln Glu Ile Ile Lys Xaa Xaa Glu Gln Leu Ile Glu Ala 
385                 390                 395                 400 


Val Asn Asn Gly Asp Phe Glu Ala Tyr Ala Lys Ile Cys Asp Pro Gly 
                405                 410                 415     


Leu Xaa Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu Val Glu Gly Met 
            420                 425                 430         


Asp Phe His Arg Phe Tyr Phe Glu Asn Leu Leu Ala Lys Asn Ser Lys 
        435                 440                 445             


Pro Ile His Xaa Xaa Ile Leu Asn Pro His Val His Val Ile Gly Glu 
    450                 455                 460                 


Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Xaa Gln Tyr Ile Asp Gly 
465                 470                 475                 480 


Gln Gly Arg Pro Arg Xaa Ser Gln Ser Glu Glu Xaa Arg Val Trp His 
                485                 490                 495     


Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His Cys Ser Gly Ala 
            500                 505                 510         


Pro Val Ala Pro Leu Gln 
        515             


<210> 4817
<211> 542
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<400> 4817
Met Ala Xaa Xaa Val Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Xaa Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Val Gly Arg Gln Xaa 
305                 310                 315                 320 


Xaa Ala Pro Ala Xaa Met Ser Xaa Ala Ala Ser Gly Xaa Xaa Met Gly 
                325                 330                 335     


Leu Val Glu Gln Ala Lys Ser Leu Leu Asn Lys Lys Ala Asp Gly Val 
            340                 345                 350         


Lys Pro Gln Xaa Asn Ser Xaa Lys Asn Ser Ala Ala Ala Xaa Ser Pro 
        355                 360                 365             


Lys Gly Xaa Leu Pro Pro Ala Ala Leu Glu Pro Gln Xaa Xaa Val Ile 
    370                 375                 380                 


His Asn Pro Val Asp Gly Ile Lys Glu Ser Ser Asp Ser Ala Asn Xaa 
385                 390                 395                 400 


Xaa Ile Glu Asp Glu Asp Ala Lys Ala Arg Lys Gln Glu Ile Ile Lys 
                405                 410                 415     


Xaa Xaa Glu Gln Leu Ile Glu Ala Val Asn Asn Gly Asp Phe Glu Ala 
            420                 425                 430         


Tyr Ala Lys Ile Cys Asp Pro Gly Leu Xaa Ser Phe Glu Pro Glu Ala 
        435                 440                 445             


Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu 
    450                 455                 460                 


Asn Leu Leu Ala Lys Asn Ser Lys Pro Ile His Xaa Xaa Ile Leu Asn 
465                 470                 475                 480 


Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile 
                485                 490                 495     


Arg Leu Xaa Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Xaa Ser Gln 
            500                 505                 510         


Ser Glu Glu Xaa Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn 
        515                 520                 525             


Val His Phe His Cys Ser Gly Ala Pro Val Ala Pro Leu Gln 
    530                 535                 540         


<210> 4818
<211> 666
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<400> 4818
Met Ala Xaa Xaa Val Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Xaa Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Val Gly Arg Gln Xaa 
305                 310                 315                 320 


Xaa Ala Pro Ala Xaa Met Ser Xaa Ala Ala Ser Gly Xaa Xaa Met Gly 
                325                 330                 335     


Leu Val Glu Gln Ala Lys Ser Leu Leu Asn Lys Lys Ala Asp Gly Val 
            340                 345                 350         


Lys Pro Gln Xaa Asn Ser Xaa Lys Asn Ser Ala Ala Ala Xaa Ser Pro 
        355                 360                 365             


Lys Gly Xaa Leu Pro Pro Ala Ala Leu Glu Pro Gln Xaa Xaa Val Ile 
    370                 375                 380                 


His Asn Pro Val Asp Gly Ile Lys Glu Ser Ser Asp Ser Ala Asn Xaa 
385                 390                 395                 400 


Xaa Ile Glu Asp Glu Asp Ala Lys Ala Pro Arg Val Pro Asp Ile Leu 
                405                 410                 415     


Ser Ser Val Arg Arg Gly Ser Gly Ala Pro Glu Ala Glu Gly Pro Leu 
            420                 425                 430         


Pro Cys Pro Ser Pro Ala Pro Phe Ser Pro Leu Pro Ala Pro Ser Pro 
        435                 440                 445             


Arg Ile Ser Asp Ile Leu Asn Ser Val Arg Arg Gly Ser Gly Xaa Pro 
    450                 455                 460                 


Glu Ala Glu Gly Pro Leu Ser Ala Gly Pro Pro Pro Cys Leu Ser Pro 
465                 470                 475                 480 


Ala Leu Leu Gly Pro Leu Ser Ser Pro Ser Pro Arg Ile Ser Asp Ile 
                485                 490                 495     


Leu Asn Ser Val Arg Arg Gly Ser Gly Xaa Pro Glu Ala Glu Gly Pro 
            500                 505                 510         


Ser Pro Val Gly Pro Pro Pro Cys Pro Ser Pro Xaa Ile Pro Gly Pro 
        515                 520                 525             


Leu Pro Xaa Pro Ser Arg Lys Gln Glu Ile Ile Lys Xaa Xaa Glu Gln 
    530                 535                 540                 


Leu Ile Glu Ala Val Asn Asn Gly Asp Phe Glu Ala Tyr Ala Lys Ile 
545                 550                 555                 560 


Cys Asp Pro Gly Leu Xaa Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu 
                565                 570                 575     


Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu Asn Leu Leu Ala 
            580                 585                 590         


Lys Asn Ser Lys Pro Ile His Xaa Xaa Ile Leu Asn Pro His Val His 
        595                 600                 605             


Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Xaa Gln 
    610                 615                 620                 


Tyr Ile Asp Gly Gln Gly Arg Pro Arg Xaa Ser Gln Ser Glu Glu Xaa 
625                 630                 635                 640 


Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His 
                645                 650                 655     


Cys Ser Gly Ala Pro Val Ala Pro Leu Gln 
            660                 665     


<210> 4819
<211> 112
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<400> 4819
Met Ala Xaa Xaa Val Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Xaa Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Xaa Val Ser Ser Arg Ser 
65                  70                  75                  80  


Trp Arg Pro Phe Ser Ile Val Xaa Lys Trp Gly Ser Ser Xaa Glu Xaa 
                85                  90                  95      


Ser Ser Arg Arg Xaa Cys Phe Trp Pro Ala Ser Ala Lys Gly Leu Gln 
            100                 105                 110         


<210> 4820
<211> 173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 4820
Met Arg Ile Pro Glu Trp Val Ala Gly Ser Pro Val Phe Xaa Pro Gln 
1               5                   10                  15      


Met His Arg Ser Xaa Pro Val Cys Pro Leu Gly Leu Gln Arg Cys Pro 
            20                  25                  30          


Gly His Trp Arg Gly Arg Gly Ala Phe Ser Val Val Arg Arg Cys Val 
        35                  40                  45              


Lys Leu Cys Xaa Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
    50                  55                  60                  


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
65                  70                  75                  80  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
                85                  90                  95      


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
            100                 105                 110         


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
        115                 120                 125             


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
    130                 135                 140                 


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
145                 150                 155                 160 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp 
                165                 170             


<210> 4821
<211> 184
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<400> 4821
Xaa Ala Lys Asn Leu Ile Asn Gln Met Leu Xaa Ile Asn Pro Ala Lys 
1               5                   10                  15      


Arg Ile Xaa Ala His Glu Ala Leu Lys His Pro Trp Val Cys Gln Arg 
            20                  25                  30          


Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val Glu Cys Leu 
        35                  40                  45              


Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile Leu Xaa Xaa 
    50                  55                  60                  


Met Leu Ala Xaa Arg Asn Phe Ser Val Gly Arg Gln Xaa Xaa Ala Pro 
65                  70                  75                  80  


Ala Xaa Met Ser Xaa Ala Ala Ser Gly Xaa Xaa Met Gly Leu Val Glu 
                85                  90                  95      


Gln Ala Lys Ser Leu Leu Asn Lys Lys Ala Asp Gly Val Lys Pro Gln 
            100                 105                 110         


Xaa Asn Ser Xaa Lys Asn Ser Ala Ala Ala Xaa Ser Pro Lys Gly Xaa 
        115                 120                 125             


Leu Pro Pro Ala Ala Leu Glu Pro Gln Xaa Xaa Val Ile His Asn Pro 
    130                 135                 140                 


Val Asp Gly Ile Lys Glu Ser Ser Asp Ser Ala Asn Xaa Xaa Ile Glu 
145                 150                 155                 160 


Asp Glu Asp Ala Lys Gly Met Asp Asp Ile Pro Gly Leu Leu Pro Pro 
                165                 170                 175     


Pro Pro Val Gly Arg His Gln Xaa 
            180                 


<210> 4822
<211> 194
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<400> 4822
Ile Leu Leu Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg 
1               5                   10                  15      


Leu Tyr Gln Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu 
            20                  25                  30          


Trp Asp Xaa Val Xaa Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu 
        35                  40                  45              


Xaa Ile Asn Pro Ala Lys Arg Ile Xaa Ala Ser Glu Ala Leu Lys His 
    50                  55                  60                  


Pro Trp Ile Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln 
65                  70                  75                  80  


Glu Xaa Val Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys 
                85                  90                  95      


Gly Ala Ile Leu Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Ala Lys 
            100                 105                 110         


Ser Leu Leu Lys Lys Pro Asp Gly Val Lys Ser Xaa Glu Ser Ser Asn 
        115                 120                 125             


Xaa Xaa Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile 
    130                 135                 140                 


Lys Val Xaa Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu 
145                 150                 155                 160 


Ala Tyr Xaa Lys Ile Cys Asp Pro Gly Leu Xaa Ala Phe Glu Pro Glu 
                165                 170                 175     


Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe 
            180                 185                 190         


Glu Asn 
        


<210> 4823
<211> 512
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<400> 4823
Met Ala Ser Xaa Xaa Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Xaa Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Lys Lys Pro Asp Gly Val Lys Ile Asn Asn Lys Ala Asn Val Val 
                325                 330                 335     


Xaa Ser Pro Lys Glu Asn Ile Pro Xaa Pro Ala Leu Glu Pro Gln Xaa 
            340                 345                 350         


Xaa Val Ile His Asn Pro Asp Gly Asn Lys Glu Ser Xaa Glu Ser Ser 
        355                 360                 365             


Asn Xaa Xaa Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile 
    370                 375                 380                 


Ile Lys Val Xaa Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe 
385                 390                 395                 400 


Glu Ala Tyr Xaa Lys Ile Cys Asp Pro Gly Leu Xaa Ala Phe Glu Pro 
                405                 410                 415     


Glu Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr 
            420                 425                 430         


Phe Glu Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Xaa Ile Ile 
        435                 440                 445             


Leu Asn Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala 
    450                 455                 460                 


Tyr Ile Arg Leu Xaa Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Xaa 
465                 470                 475                 480 


Met Gln Ser Glu Glu Xaa Arg Val Trp His Arg Arg Asp Gly Lys Trp 
                485                 490                 495     


Gln Asn Val His Phe His Arg Ser Gly Ser Pro Xaa Val Pro Ile Lys 
            500                 505                 510         


<210> 4824
<211> 533
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<400> 4824
Met Ala Ser Xaa Xaa Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Xaa Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Lys Lys Pro Asp Gly Val Lys Ile Asn Asn Lys Ala Asn Val Val 
                325                 330                 335     


Xaa Ser Pro Lys Glu Asn Ile Pro Xaa Pro Ala Leu Glu Pro Gln Xaa 
            340                 345                 350         


Xaa Val Ile His Asn Pro Asp Gly Asn Lys Glu Ser Xaa Glu Ser Ser 
        355                 360                 365             


Asn Xaa Xaa Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile 
    370                 375                 380                 


Ile Lys Val Xaa Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe 
385                 390                 395                 400 


Glu Ala Tyr Xaa Lys Ile Cys Asp Pro Gly Leu Xaa Ala Phe Glu Pro 
                405                 410                 415     


Glu Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr 
            420                 425                 430         


Phe Glu Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Xaa Ile Ile 
        435                 440                 445             


Leu Asn Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala 
    450                 455                 460                 


Tyr Ile Arg Leu Xaa Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Xaa 
465                 470                 475                 480 


Met Gln Ser Glu Glu Xaa Arg Val Trp His Arg Arg Asp Gly Lys Trp 
                485                 490                 495     


Gln Asn Val His Phe His Arg Ser Gly Ser Pro Xaa Val Pro Ile Lys 
            500                 505                 510         


Pro Pro Cys Ile Pro Asn Gly Lys Glu Asn Phe Ser Gly Gly Xaa Ser 
        515                 520                 525             


Leu Trp Gln Asn Ile 
    530             


<210> 4825
<211> 478
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<400> 4825
Met Ala Ser Xaa Xaa Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Xaa Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
        115                 120                 125             


Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Lys Lys Pro Asp Gly Val Lys Glu Ser Xaa Glu Ser Ser Asn Xaa 
                325                 330                 335     


Xaa Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys 
            340                 345                 350         


Val Xaa Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala 
        355                 360                 365             


Tyr Xaa Lys Ile Cys Asp Pro Gly Leu Xaa Ala Phe Glu Pro Glu Ala 
    370                 375                 380                 


Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu 
385                 390                 395                 400 


Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Xaa Ile Ile Leu Asn 
                405                 410                 415     


Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile 
            420                 425                 430         


Arg Leu Xaa Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Xaa Met Gln 
        435                 440                 445             


Ser Glu Glu Xaa Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn 
    450                 455                 460                 


Val His Phe His Arg Ser Gly Ser Pro Xaa Val Pro Ile Lys 
465                 470                 475             


<210> 4826
<211> 478
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<400> 4826
Met Ala Ser Xaa Xaa Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Xaa Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
        115                 120                 125             


Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Lys Lys Pro Asp Gly Val Lys Glu Ser Xaa Glu Ser Ser Asn Xaa 
                325                 330                 335     


Xaa Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys 
            340                 345                 350         


Val Xaa Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala 
        355                 360                 365             


Tyr Xaa Lys Ile Cys Asp Pro Gly Leu Xaa Ala Phe Glu Pro Glu Ala 
    370                 375                 380                 


Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu 
385                 390                 395                 400 


Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Xaa Ile Ile Leu Asn 
                405                 410                 415     


Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile 
            420                 425                 430         


Arg Leu Xaa Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Xaa Met Gln 
        435                 440                 445             


Ser Glu Glu Xaa Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn 
    450                 455                 460                 


Val His Phe His Arg Ser Gly Ser Pro Xaa Val Pro Ile Asn 
465                 470                 475             


<210> 4827
<211> 489
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<400> 4827
Met Ala Ser Xaa Xaa Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Xaa Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
        115                 120                 125             


Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Lys Lys Pro Asp Gly Val Lys Lys Arg Lys Ser Ser Ser Ser Val 
                325                 330                 335     


Gln Met Met Glu Ser Xaa Glu Ser Ser Asn Xaa Xaa Ile Glu Asp Glu 
            340                 345                 350         


Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys Val Xaa Glu Gln Leu 
        355                 360                 365             


Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala Tyr Xaa Lys Ile Cys 
    370                 375                 380                 


Asp Pro Gly Leu Xaa Ala Phe Glu Pro Glu Ala Leu Gly Asn Leu Val 
385                 390                 395                 400 


Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu Asn Ala Leu Ser Lys 
                405                 410                 415     


Ser Asn Lys Pro Ile His Xaa Ile Ile Leu Asn Pro His Val His Leu 
            420                 425                 430         


Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Xaa Gln Tyr 
        435                 440                 445             


Met Asp Gly Ser Gly Met Pro Lys Xaa Met Gln Ser Glu Glu Xaa Arg 
    450                 455                 460                 


Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His Arg 
465                 470                 475                 480 


Ser Gly Ser Pro Xaa Val Pro Ile Lys 
                485                 


<210> 4828
<211> 492
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<400> 4828
Met Ala Ser Xaa Xaa Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Xaa Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
        115                 120                 125             


Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Lys Lys Pro Asp Gly Val Lys Glu Pro Gln Xaa Xaa Val Ile His 
                325                 330                 335     


Asn Pro Asp Gly Asn Lys Glu Ser Xaa Glu Ser Ser Asn Xaa Xaa Ile 
            340                 345                 350         


Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys Val Xaa 
        355                 360                 365             


Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala Tyr Xaa 
    370                 375                 380                 


Lys Ile Cys Asp Pro Gly Leu Xaa Ala Phe Glu Pro Glu Ala Leu Gly 
385                 390                 395                 400 


Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu Asn Ala 
                405                 410                 415     


Leu Ser Lys Ser Asn Lys Pro Ile His Xaa Ile Ile Leu Asn Pro His 
            420                 425                 430         


Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu 
        435                 440                 445             


Xaa Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Xaa Met Gln Ser Glu 
    450                 455                 460                 


Glu Xaa Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn Val His 
465                 470                 475                 480 


Phe His Arg Ser Gly Ser Pro Xaa Val Pro Ile Lys 
                485                 490         


<210> 4829
<211> 498
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<400> 4829
Met Ala Ser Xaa Xaa Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Xaa Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
        115                 120                 125             


Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Ala Lys Ser Leu Leu 
305                 310                 315                 320 


Lys Lys Pro Asp Gly Val Lys Glu Ser Xaa Glu Ser Ser Asn Xaa Xaa 
                325                 330                 335     


Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys Val 
            340                 345                 350         


Xaa Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala Tyr 
        355                 360                 365             


Xaa Lys Ile Cys Asp Pro Gly Leu Xaa Ala Phe Glu Pro Glu Ala Leu 
    370                 375                 380                 


Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu Asn 
385                 390                 395                 400 


Ala Leu Ser Lys Ser Asn Lys Pro Ile His Xaa Ile Ile Leu Asn Pro 
                405                 410                 415     


His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile Arg 
            420                 425                 430         


Leu Xaa Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Xaa Met Gln Ser 
        435                 440                 445             


Glu Glu Xaa Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn Val 
    450                 455                 460                 


His Phe His Arg Ser Gly Ser Pro Xaa Val Pro Ile Lys Pro Pro Cys 
465                 470                 475                 480 


Ile Pro Asn Gly Lys Glu Asn Phe Ser Gly Gly Xaa Ser Leu Trp Gln 
                485                 490                 495     


Asn Ile 
        


<210> 4830
<211> 499
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<400> 4830
Met Ala Ser Xaa Xaa Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Xaa Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
        115                 120                 125             


Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Lys Lys Pro Asp Gly Val Lys Glu Ser Xaa Glu Ser Ser Asn Xaa 
                325                 330                 335     


Xaa Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys 
            340                 345                 350         


Val Xaa Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala 
        355                 360                 365             


Tyr Xaa Lys Ile Cys Asp Pro Gly Leu Xaa Ala Phe Glu Pro Glu Ala 
    370                 375                 380                 


Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu 
385                 390                 395                 400 


Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Xaa Ile Ile Leu Asn 
                405                 410                 415     


Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile 
            420                 425                 430         


Arg Leu Xaa Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Xaa Met Gln 
        435                 440                 445             


Ser Glu Glu Xaa Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn 
    450                 455                 460                 


Val His Phe His Arg Ser Gly Ser Pro Xaa Val Pro Ile Lys Pro Pro 
465                 470                 475                 480 


Cys Ile Pro Asn Gly Lys Glu Asn Phe Ser Gly Gly Xaa Ser Leu Trp 
                485                 490                 495     


Gln Asn Ile 
            


<210> 4831
<211> 510
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<400> 4831
Met Ala Ser Xaa Xaa Xaa Cys Xaa Arg Phe Xaa Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Xaa Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
        115                 120                 125             


Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Ala Xaa Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Lys Lys Pro Asp Gly Val Lys Lys Arg Lys Ser Ser Ser Ser Val 
                325                 330                 335     


Gln Met Met Glu Ser Xaa Glu Ser Ser Asn Xaa Xaa Ile Glu Asp Glu 
            340                 345                 350         


Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys Val Xaa Glu Gln Leu 
        355                 360                 365             


Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala Tyr Xaa Lys Ile Cys 
    370                 375                 380                 


Asp Pro Gly Leu Xaa Ala Phe Glu Pro Glu Ala Leu Gly Asn Leu Val 
385                 390                 395                 400 


Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu Asn Ala Leu Ser Lys 
                405                 410                 415     


Ser Asn Lys Pro Ile His Xaa Ile Ile Leu Asn Pro His Val His Leu 
            420                 425                 430         


Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Xaa Gln Tyr 
        435                 440                 445             


Met Asp Gly Ser Gly Met Pro Lys Xaa Met Gln Ser Glu Glu Xaa Arg 
    450                 455                 460                 


Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His Arg 
465                 470                 475                 480 


Ser Gly Ser Pro Xaa Val Pro Ile Lys Pro Pro Cys Ile Pro Asn Gly 
                485                 490                 495     


Lys Glu Asn Phe Ser Gly Gly Xaa Ser Leu Trp Gln Asn Ile 
            500                 505                 510 


<210> 4832
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<400> 4832
Xaa Arg Lys Leu Lys Gly Ala Ile Leu Xaa Xaa Met Leu Ala Xaa Arg 
1               5                   10                  15      


Asn Phe Ser Ala Ala Lys Ser Leu Leu Lys Lys Pro Asp Gly Val Lys 
            20                  25                  30          


Glu Ser Xaa Glu Ser Ser Asn Xaa Xaa Ile Glu Asp Glu Asp Val Lys 
        35                  40                  45              


Ala Arg Lys Gln Glu Ile Ile Lys Val Xaa Glu Gln Leu Ile Glu Ala 
    50                  55                  60                  


Ile Asn Asn Gly Asp Phe Glu Ala Tyr Xaa Lys Ile Cys Asp Pro Gly 
65                  70                  75                  80  


Leu Xaa Ala Phe Glu Pro Glu Ala Leu Gly Asn Leu Val Glu Gly Met 
                85                  90                  95      


Asp Phe His Arg Phe Tyr Phe Glu Asn Ala Leu Ser Lys Ser Asn Lys 
            100                 105                 110         


Pro Ile His Xaa Ile Ile Leu Asn Pro His Val His Leu Val Gly Asp 
        115                 120                 125             


Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Xaa Gln Tyr Met Asp Gly 
    130                 135                 140                 


Ser Gly Met Pro Lys Xaa Met Gln Ser Glu Glu Xaa Arg Val Trp His 
145                 150                 155                 160 


Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His Arg Ser Gly Ser 
                165                 170                 175     


Pro Xaa Val Pro Ile Lys 
            180         


<210> 4833
<211> 495
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<400> 4833
Met Ala Xaa Xaa Ala Xaa Cys Xaa Arg Phe Xaa Asp Asp Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Lys Xaa Ser Xaa Gln Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile His Gln Ile Leu Glu Ser Val Asn His Ile His 
        115                 120                 125             


Gln His Asp Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala Asp Gln Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Glu Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Val Ser Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Asn Lys Lys Ser Asp Gly Gly Val Lys Glu Pro Gln Xaa Xaa Val 
                325                 330                 335     


Val His Asn Ala Xaa Asp Gly Ile Lys Gly Ser Xaa Glu Ser Cys Asn 
            340                 345                 350         


Xaa Xaa Xaa Glu Asp Glu Asp Leu Lys Val Arg Lys Gln Glu Ile Ile 
        355                 360                 365             


Lys Ile Xaa Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu 
    370                 375                 380                 


Ala Tyr Xaa Lys Ile Cys Asp Pro Gly Leu Xaa Ser Phe Glu Pro Glu 
385                 390                 395                 400 


Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Lys Phe Tyr Phe 
                405                 410                 415     


Glu Asn Leu Leu Ser Lys Asn Ser Lys Pro Ile His Xaa Xaa Ile Leu 
            420                 425                 430         


Asn Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr 
        435                 440                 445             


Ile Arg Leu Xaa Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Xaa Ser 
    450                 455                 460                 


Gln Ser Glu Glu Xaa Arg Val Trp His Arg Arg Asp Gly Lys Trp Leu 
465                 470                 475                 480 


Asn Val His Tyr His Cys Ser Gly Ala Pro Ala Ala Pro Leu Gln 
                485                 490                 495 


<210> 4834
<211> 516
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<400> 4834
Met Ala Xaa Xaa Ala Xaa Cys Xaa Arg Phe Xaa Asp Asp Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Lys Xaa Ser Xaa Gln Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile His Gln Ile Leu Glu Ser Val Asn His Ile His 
        115                 120                 125             


Gln His Asp Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala Asp Gln Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Glu Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Val Ser Arg Asn Phe Ser Val Gly Arg Gln Ser 
305                 310                 315                 320 


Ser Ala Pro Ala Ser Pro Ala Ala Ser Ala Ala Gly Leu Ala Gly Gln 
                325                 330                 335     


Ala Ala Lys Ser Leu Leu Asn Lys Lys Ser Asp Gly Gly Val Lys Glu 
            340                 345                 350         


Pro Gln Xaa Xaa Val Val His Asn Ala Xaa Asp Gly Ile Lys Gly Ser 
        355                 360                 365             


Xaa Glu Ser Cys Asn Xaa Xaa Xaa Glu Asp Glu Asp Leu Lys Val Arg 
    370                 375                 380                 


Lys Gln Glu Ile Ile Lys Ile Xaa Glu Gln Leu Ile Glu Ala Ile Asn 
385                 390                 395                 400 


Asn Gly Asp Phe Glu Ala Tyr Xaa Lys Ile Cys Asp Pro Gly Leu Xaa 
                405                 410                 415     


Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe 
            420                 425                 430         


His Lys Phe Tyr Phe Glu Asn Leu Leu Ser Lys Asn Ser Lys Pro Ile 
        435                 440                 445             


His Xaa Xaa Ile Leu Asn Pro His Val His Val Ile Gly Glu Asp Ala 
    450                 455                 460                 


Ala Cys Ile Ala Tyr Ile Arg Leu Xaa Gln Tyr Ile Asp Gly Gln Gly 
465                 470                 475                 480 


Arg Pro Arg Xaa Ser Gln Ser Glu Glu Xaa Arg Val Trp His Arg Arg 
                485                 490                 495     


Asp Gly Lys Trp Leu Asn Val His Tyr His Cys Ser Gly Ala Pro Ala 
            500                 505                 510         


Ala Pro Leu Gln 
        515     


<210> 4835
<211> 527
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<400> 4835
Met Ala Xaa Xaa Ala Xaa Cys Xaa Arg Phe Xaa Asp Asp Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Lys Xaa Ser Xaa Gln Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile His Gln Ile Leu Glu Ser Val Asn His Ile His 
        115                 120                 125             


Gln His Asp Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala Asp Gln Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Glu Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Val Ser Arg Asn Phe Ser Val Gly Arg Gln Ser 
305                 310                 315                 320 


Ser Ala Pro Ala Ser Pro Ala Ala Ser Ala Ala Gly Leu Ala Gly Gln 
                325                 330                 335     


Ala Ala Lys Ser Leu Leu Asn Lys Lys Ser Asp Gly Gly Val Lys Lys 
            340                 345                 350         


Arg Lys Ser Ser Ser Ser Val His Leu Met Glu Pro Gln Xaa Xaa Val 
        355                 360                 365             


Val His Asn Ala Xaa Asp Gly Ile Lys Gly Ser Xaa Glu Ser Cys Asn 
    370                 375                 380                 


Xaa Xaa Xaa Glu Asp Glu Asp Leu Lys Val Arg Lys Gln Glu Ile Ile 
385                 390                 395                 400 


Lys Ile Xaa Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu 
                405                 410                 415     


Ala Tyr Xaa Lys Ile Cys Asp Pro Gly Leu Xaa Ser Phe Glu Pro Glu 
            420                 425                 430         


Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Lys Phe Tyr Phe 
        435                 440                 445             


Glu Asn Leu Leu Ser Lys Asn Ser Lys Pro Ile His Xaa Xaa Ile Leu 
    450                 455                 460                 


Asn Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr 
465                 470                 475                 480 


Ile Arg Leu Xaa Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Xaa Ser 
                485                 490                 495     


Gln Ser Glu Glu Xaa Arg Val Trp His Arg Arg Asp Gly Lys Trp Leu 
            500                 505                 510         


Asn Val His Tyr His Cys Ser Gly Ala Pro Ala Ala Pro Leu Gln 
        515                 520                 525         


<210> 4836
<211> 529
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<400> 4836
Met Ala Xaa Xaa Ala Xaa Cys Xaa Arg Phe Xaa Asp Asp Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Lys Xaa Ser Xaa Gln Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile His Gln Ile Leu Glu Ser Val Asn His Ile His 
        115                 120                 125             


Gln His Asp Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala Asp Gln Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Glu Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Val Ser Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Asn Lys Lys Ser Asp Gly Gly Val Lys Lys Arg Lys Ser Ser Ser 
                325                 330                 335     


Ser Val His Leu Met Pro Gln Ser Asn Asn Lys Asn Ser Leu Val Ser 
            340                 345                 350         


Pro Ala Gln Glu Pro Ala Pro Leu Gln Xaa Ala Met Glu Pro Gln Xaa 
        355                 360                 365             


Xaa Val Val His Asn Ala Xaa Asp Gly Ile Lys Gly Ser Xaa Glu Ser 
    370                 375                 380                 


Cys Asn Xaa Xaa Xaa Glu Asp Glu Asp Leu Lys Val Arg Lys Gln Glu 
385                 390                 395                 400 


Ile Ile Lys Ile Xaa Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp 
                405                 410                 415     


Phe Glu Ala Tyr Xaa Lys Ile Cys Asp Pro Gly Leu Xaa Ser Phe Glu 
            420                 425                 430         


Pro Glu Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Lys Phe 
        435                 440                 445             


Tyr Phe Glu Asn Leu Leu Ser Lys Asn Ser Lys Pro Ile His Xaa Xaa 
    450                 455                 460                 


Ile Leu Asn Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile 
465                 470                 475                 480 


Ala Tyr Ile Arg Leu Xaa Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg 
                485                 490                 495     


Xaa Ser Gln Ser Glu Glu Xaa Arg Val Trp His Arg Arg Asp Gly Lys 
            500                 505                 510         


Trp Leu Asn Val His Tyr His Cys Ser Gly Ala Pro Ala Ala Pro Leu 
        515                 520                 525             


Gln 
    


<210> 4837
<211> 539
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<400> 4837
Met Ala Xaa Xaa Ala Xaa Cys Xaa Arg Phe Xaa Asp Asp Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Lys Xaa Ser Xaa Gln Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile His Gln Ile Leu Glu Ser Val Asn His Ile His 
        115                 120                 125             


Gln His Asp Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala Asp Gln Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Glu Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Val Ser Arg Asn Phe Ser Val Gly Arg Gln Ser 
305                 310                 315                 320 


Ser Ala Pro Ala Ser Pro Ala Ala Ser Ala Ala Gly Leu Ala Gly Gln 
                325                 330                 335     


Ala Ala Lys Ser Leu Leu Asn Lys Lys Ser Asp Gly Gly Val Lys Pro 
            340                 345                 350         


Gln Ser Asn Asn Lys Asn Ser Leu Val Ser Pro Ala Gln Glu Pro Ala 
        355                 360                 365             


Pro Leu Gln Xaa Ala Met Glu Pro Gln Xaa Xaa Val Val His Asn Ala 
    370                 375                 380                 


Xaa Asp Gly Ile Lys Gly Ser Xaa Glu Ser Cys Asn Xaa Xaa Xaa Glu 
385                 390                 395                 400 


Asp Glu Asp Leu Lys Val Arg Lys Gln Glu Ile Ile Lys Ile Xaa Glu 
                405                 410                 415     


Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala Tyr Xaa Lys 
            420                 425                 430         


Ile Cys Asp Pro Gly Leu Xaa Ser Phe Glu Pro Glu Ala Leu Gly Asn 
        435                 440                 445             


Leu Val Glu Gly Met Asp Phe His Lys Phe Tyr Phe Glu Asn Leu Leu 
    450                 455                 460                 


Ser Lys Asn Ser Lys Pro Ile His Xaa Xaa Ile Leu Asn Pro His Val 
465                 470                 475                 480 


His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Xaa 
                485                 490                 495     


Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Xaa Ser Gln Ser Glu Glu 
            500                 505                 510         


Xaa Arg Val Trp His Arg Arg Asp Gly Lys Trp Leu Asn Val His Tyr 
        515                 520                 525             


His Cys Ser Gly Ala Pro Ala Ala Pro Leu Gln 
    530                 535                 


<210> 4838
<211> 556
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<400> 4838
Met Ala Xaa Xaa Ala Xaa Cys Xaa Arg Phe Xaa Asp Asp Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Lys Xaa Ser Xaa Gln Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile His Gln Ile Leu Glu Ser Val Asn His Ile His 
        115                 120                 125             


Gln His Asp Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala Asp Gln Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Glu Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Val Ser Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Asn Lys Lys Ser Asp Gly Gly Val Lys Pro Gln Ser Asn Asn Lys 
                325                 330                 335     


Asn Ser Leu Val Ser Pro Ala Gln Glu Pro Ala Pro Leu Gln Xaa Ala 
            340                 345                 350         


Met Glu Pro Gln Xaa Xaa Val Val His Asn Ala Xaa Asp Gly Ile Lys 
        355                 360                 365             


Gly Ser Xaa Glu Ser Cys Asn Xaa Xaa Xaa Glu Asp Glu Asp Leu Lys 
    370                 375                 380                 


Ala Ala Pro Leu Arg Xaa Gly Asn Gly Ser Ser Val Pro Glu Gly Arg 
385                 390                 395                 400 


Ser Ser Arg Asp Arg Xaa Ala Pro Ser Ala Gly Met Gln Pro Gln Pro 
                405                 410                 415     


Ser Leu Cys Ser Ser Ala Met Arg Lys Gln Glu Ile Ile Lys Ile Xaa 
            420                 425                 430         


Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala Tyr Xaa 
        435                 440                 445             


Lys Ile Cys Asp Pro Gly Leu Xaa Ser Phe Glu Pro Glu Ala Leu Gly 
    450                 455                 460                 


Asn Leu Val Glu Gly Met Asp Phe His Lys Phe Tyr Phe Glu Asn Leu 
465                 470                 475                 480 


Leu Ser Lys Asn Ser Lys Pro Ile His Xaa Xaa Ile Leu Asn Pro His 
                485                 490                 495     


Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu 
            500                 505                 510         


Xaa Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Xaa Ser Gln Ser Glu 
        515                 520                 525             


Glu Xaa Arg Val Trp His Arg Arg Asp Gly Lys Trp Leu Asn Val His 
    530                 535                 540                 


Tyr His Cys Ser Gly Ala Pro Ala Ala Pro Leu Gln 
545                 550                 555     


<210> 4839
<211> 558
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<400> 4839
Met Ala Xaa Xaa Ala Xaa Cys Xaa Arg Phe Xaa Asp Asp Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Lys Xaa Ser Xaa Gln Glu Tyr Ala Ala Lys Ile Ile Asn Xaa Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile His Gln Ile Leu Glu Ser Val Asn His Ile His 
        115                 120                 125             


Gln His Asp Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Xaa Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa 
225                 230                 235                 240 


Val Xaa Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Xaa Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Xaa Ala Asp Gln Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val 
        275                 280                 285             


Glu Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Xaa Xaa Met Leu Val Ser Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Asn Lys Lys Ser Asp Gly Gly Val Lys Lys Arg Lys Ser Ser Ser 
                325                 330                 335     


Ser Val His Leu Met Pro Gln Ser Asn Asn Lys Asn Ser Leu Val Ser 
            340                 345                 350         


Pro Ala Gln Glu Pro Ala Pro Leu Gln Xaa Ala Met Glu Pro Gln Xaa 
        355                 360                 365             


Xaa Val Val His Asn Ala Xaa Asp Gly Ile Lys Gly Ser Xaa Glu Ser 
    370                 375                 380                 


Cys Asn Xaa Xaa Xaa Glu Asp Glu Asp Leu Lys Gly Arg Val Pro Glu 
385                 390                 395                 400 


Gly Arg Ser Ser Arg Asp Arg Xaa Ala Pro Ser Ala Gly Met Gln Pro 
                405                 410                 415     


Gln Pro Ser Leu Cys Ser Ser Ala Met Arg Lys Gln Glu Ile Ile Lys 
            420                 425                 430         


Ile Xaa Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala 
        435                 440                 445             


Tyr Xaa Lys Ile Cys Asp Pro Gly Leu Xaa Ser Phe Glu Pro Glu Ala 
    450                 455                 460                 


Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Lys Phe Tyr Phe Glu 
465                 470                 475                 480 


Asn Leu Leu Ser Lys Asn Ser Lys Pro Ile His Xaa Xaa Ile Leu Asn 
                485                 490                 495     


Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile 
            500                 505                 510         


Arg Leu Xaa Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Xaa Ser Gln 
        515                 520                 525             


Ser Glu Glu Xaa Arg Val Trp His Arg Arg Asp Gly Lys Trp Leu Asn 
    530                 535                 540                 


Val His Tyr His Cys Ser Gly Ala Pro Ala Ala Pro Leu Gln 
545                 550                 555             


<210> 4840
<211> 453
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<400> 4840
Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile Ser 
1               5                   10                  15      


Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Xaa Gly Gly Glu 
            20                  25                  30          


Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp Ala 
        35                  40                  45              


Ser His Cys Ile His Gln Ile Leu Glu Ser Val Asn His Ile His Gln 
    50                  55                  60                  


His Asp Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu Ala 
65                  70                  75                  80  


Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu Ala 
                85                  90                  95      


Ile Glu Val Gln Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly Xaa 
            100                 105                 110         


Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly Lys 
        115                 120                 125             


Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu Val 
    130                 135                 140                 


Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln Gln 
145                 150                 155                 160 


Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Xaa Val 
                165                 170                 175     


Xaa Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Xaa Ile Asn Pro 
            180                 185                 190         


Ala Lys Arg Ile Xaa Ala Asp Gln Ala Leu Lys His Pro Trp Val Cys 
        195                 200                 205             


Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln Glu Xaa Val Glu 
    210                 215                 220                 


Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile Leu 
225                 230                 235                 240 


Xaa Xaa Met Leu Val Ser Arg Asn Phe Ser Ala Ala Lys Ser Leu Leu 
                245                 250                 255     


Asn Lys Lys Ser Asp Gly Gly Val Lys Pro Gln Ser Asn Asn Lys Asn 
            260                 265                 270         


Ser Leu Val Ser Pro Ala Gln Glu Pro Ala Pro Leu Gln Xaa Ala Met 
        275                 280                 285             


Glu Pro Gln Xaa Xaa Val Val His Asn Ala Xaa Asp Gly Ile Lys Gly 
    290                 295                 300                 


Ser Xaa Glu Ser Cys Asn Xaa Xaa Xaa Glu Asp Glu Asp Leu Lys Val 
305                 310                 315                 320 


Arg Lys Gln Glu Ile Ile Lys Ile Xaa Glu Gln Leu Ile Glu Ala Ile 
                325                 330                 335     


Asn Asn Gly Asp Phe Glu Ala Tyr Xaa Lys Ile Cys Asp Pro Gly Leu 
            340                 345                 350         


Xaa Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu Val Glu Gly Met Asp 
        355                 360                 365             


Phe His Lys Phe Tyr Phe Glu Asn Leu Leu Ser Lys Asn Ser Lys Pro 
    370                 375                 380                 


Ile His Xaa Xaa Ile Leu Asn Pro His Val His Val Ile Gly Glu Asp 
385                 390                 395                 400 


Ala Ala Cys Ile Ala Tyr Ile Arg Leu Xaa Gln Tyr Ile Asp Gly Gln 
                405                 410                 415     


Gly Arg Pro Arg Xaa Ser Gln Ser Glu Glu Xaa Arg Val Trp His Arg 
            420                 425                 430         


Arg Asp Gly Lys Trp Leu Asn Val His Tyr His Cys Ser Gly Ala Pro 
        435                 440                 445             


Ala Ala Pro Leu Gln 
    450             


<210> 4841
<211> 335
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<400> 4841
Xaa Tyr Gln Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu 
1               5                   10                  15      


Trp Asp Xaa Val Xaa Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu 
            20                  25                  30          


Xaa Ile Asn Pro Ala Lys Arg Ile Xaa Ala Asp Gln Ala Leu Lys His 
        35                  40                  45              


Pro Trp Val Cys Gln Arg Ser Xaa Val Ala Ser Met Met His Arg Gln 
    50                  55                  60                  


Glu Xaa Val Glu Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys 
65                  70                  75                  80  


Gly Ala Ile Leu Xaa Xaa Met Leu Val Ser Arg Asn Phe Ser Ala Ala 
                85                  90                  95      


Lys Ser Leu Leu Asn Lys Lys Ser Asp Gly Gly Val Lys Pro Gln Ser 
            100                 105                 110         


Asn Asn Lys Asn Ser Leu Val Ser Pro Ala Gln Glu Pro Ala Pro Leu 
        115                 120                 125             


Gln Xaa Ala Met Glu Pro Gln Xaa Xaa Val Val His Asn Ala Xaa Asp 
    130                 135                 140                 


Gly Ile Lys Gly Ser Xaa Glu Ser Cys Asn Xaa Xaa Xaa Glu Asp Glu 
145                 150                 155                 160 


Asp Leu Lys Ala Ala Pro Leu Arg Xaa Gly Asn Gly Ser Ser Val Pro 
                165                 170                 175     


Glu Gly Arg Ser Ser Arg Asp Arg Xaa Ala Pro Ser Ala Gly Met Gln 
            180                 185                 190         


Pro Gln Pro Ser Leu Cys Ser Ser Ala Met Arg Lys Gln Glu Ile Ile 
        195                 200                 205             


Lys Ile Xaa Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu 
    210                 215                 220                 


Ala Tyr Xaa Lys Ile Cys Asp Pro Gly Leu Xaa Ser Phe Glu Pro Glu 
225                 230                 235                 240 


Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Lys Phe Tyr Phe 
                245                 250                 255     


Glu Asn Leu Leu Ser Lys Asn Ser Lys Pro Ile His Xaa Xaa Ile Leu 
            260                 265                 270         


Asn Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr 
        275                 280                 285             


Ile Arg Leu Xaa Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Xaa Ser 
    290                 295                 300                 


Gln Ser Glu Glu Xaa Arg Val Trp His Arg Arg Asp Gly Lys Trp Leu 
305                 310                 315                 320 


Asn Val His Tyr His Cys Ser Gly Ala Pro Ala Ala Pro Leu Gln 
                325                 330                 335 


<210> 4842
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 4842
Met Leu Lys Val Xaa Val Pro Ser Cys Ser Ala Ser Ser Cys Ser Ser 
1               5                   10                  15      


Val Xaa Ala Ser Ala Ala Pro Gly Xaa Ala Ser Leu Val Pro Asp Tyr 
            20                  25                  30          


Trp Ile Asp Gly Ser Asn Arg Asp Ala Leu Ser Asp Phe Phe Glu Val 
        35                  40                  45              


Glu Ser Glu Leu Gly Arg Gly Ala Xaa Ser Ile Val Tyr Arg Cys Lys 
    50                  55                  60                  


Gln Lys Gly Xaa Gln Lys Pro Tyr Ala Leu Lys Val Leu Lys Lys Xaa 
65                  70                  75                  80  


Asp Cys Gly Lys Gly Ile Leu Gln 
                85              


<210> 4843
<211> 109
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 4843
Met Leu Lys Val Xaa Val Pro Ser Cys Ser Ala Ser Ser Cys Ser Ser 
1               5                   10                  15      


Val Xaa Ala Ser Ala Ala Pro Gly Xaa Ala Ser Leu Val Pro Asp Tyr 
            20                  25                  30          


Trp Ile Asp Gly Ser Asn Arg Asp Ala Leu Ser Asp Phe Phe Glu Val 
        35                  40                  45              


Glu Ser Glu Leu Gly Arg Gly Ala Xaa Ser Ile Val Tyr Arg Cys Lys 
    50                  55                  60                  


Gln Lys Gly Xaa Gln Lys Pro Tyr Ala Leu Lys Val Leu Lys Lys Xaa 
65                  70                  75                  80  


Val Asp Lys Lys Ile Val Arg Xaa Glu Ile Gly Val Leu Leu Arg Leu 
                85                  90                  95      


Ser His Pro Asn Ile Asp Cys Gly Lys Gly Ile Leu Gln 
            100                 105                 


<210> 4844
<211> 142
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<400> 4844
Met Leu Lys Val Xaa Val Pro Ser Cys Ser Ala Ser Ser Cys Ser Ser 
1               5                   10                  15      


Val Xaa Ala Ser Ala Ala Pro Gly Xaa Ala Ser Leu Val Pro Asp Tyr 
            20                  25                  30          


Trp Ile Asp Gly Ser Asn Arg Asp Ala Leu Ser Asp Phe Phe Glu Val 
        35                  40                  45              


Glu Ser Glu Leu Gly Arg Gly Ala Xaa Ser Ile Val Tyr Arg Cys Lys 
    50                  55                  60                  


Gln Lys Gly Xaa Gln Lys Pro Tyr Ala Leu Lys Val Leu Lys Lys Xaa 
65                  70                  75                  80  


Val Asp Lys Lys Ile Val Arg Xaa Glu Ile Gly Val Leu Leu Arg Leu 
                85                  90                  95      


Ser His Pro Asn Ile Ile Lys Leu Lys Glu Ile Phe Glu Xaa Pro Xaa 
            100                 105                 110         


Glu Ile Ser Leu Val Leu Glu Leu Val Xaa Gly Gly Glu Leu Phe Asp 
        115                 120                 125             


Arg Ile Val Glu Lys Gly Tyr Tyr Ser Glu Arg Asp Ala Ala 
    130                 135                 140         


<210> 4845
<211> 473
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<400> 4845
Met Leu Lys Val Xaa Val Pro Ser Cys Ser Ala Ser Ser Cys Ser Ser 
1               5                   10                  15      


Val Xaa Ala Ser Ala Ala Pro Gly Xaa Ala Ser Leu Val Pro Asp Tyr 
            20                  25                  30          


Trp Ile Asp Gly Ser Asn Arg Asp Ala Leu Ser Asp Phe Phe Glu Val 
        35                  40                  45              


Glu Ser Glu Leu Gly Arg Gly Ala Xaa Ser Ile Val Tyr Arg Cys Lys 
    50                  55                  60                  


Gln Lys Gly Xaa Gln Lys Pro Tyr Ala Leu Lys Val Leu Lys Lys Xaa 
65                  70                  75                  80  


Val Asp Lys Lys Ile Val Arg Xaa Glu Ile Gly Val Leu Leu Arg Leu 
                85                  90                  95      


Ser His Pro Asn Ile Ile Lys Leu Lys Glu Ile Phe Glu Xaa Pro Xaa 
            100                 105                 110         


Glu Ile Ser Leu Val Leu Glu Leu Val Xaa Gly Gly Glu Leu Phe Asp 
        115                 120                 125             


Arg Ile Val Glu Lys Gly Tyr Tyr Ser Glu Arg Asp Ala Ala Asp Ala 
    130                 135                 140                 


Val Lys Gln Ile Leu Glu Ala Val Ala Tyr Leu His Glu Asn Gly Ile 
145                 150                 155                 160 


Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Tyr Ala Xaa Pro Ala 
                165                 170                 175     


Pro Asp Ala Pro Leu Lys Ile Ala Asp Phe Gly Leu Ser Lys Ile Val 
            180                 185                 190         


Glu His Gln Val Leu Met Lys Xaa Val Cys Gly Xaa Pro Gly Tyr Cys 
        195                 200                 205             


Ala Pro Glu Ile Leu Arg Gly Cys Ala Tyr Gly Pro Glu Val Asp Met 
    210                 215                 220                 


Trp Ser Val Gly Ile Ile Xaa Tyr Ile Leu Leu Cys Gly Phe Glu Pro 
225                 230                 235                 240 


Phe Tyr Asp Glu Arg Gly Asp Gln Phe Met Phe Arg Arg Ile Leu Asn 
                245                 250                 255     


Cys Glu Tyr Tyr Phe Ile Ser Pro Trp Trp Asp Glu Val Ser Leu Asn 
            260                 265                 270         


Ala Lys Asp Leu Val Arg Lys Leu Ile Val Leu Asp Pro Lys Lys Arg 
        275                 280                 285             


Leu Xaa Xaa Phe Gln Ala Leu Gln His Pro Trp Val Xaa Gly Lys Ala 
    290                 295                 300                 


Ala Asn Phe Val His Met Asp Xaa Ala Gln Lys Lys Leu Gln Glu Phe 
305                 310                 315                 320 


Asn Ala Arg Arg Lys Leu Lys Ala Ala Val Lys Ala Val Val Ala Ser 
                325                 330                 335     


Ser Arg Leu Gly Ser Ala Ser Ser Ser His Gly Ser Ile Gln Glu Ser 
            340                 345                 350         


His Lys Ala Ser Arg Asp Pro Ser Pro Ile Gln Asp Gly Asn Glu Asp 
        355                 360                 365             


Met Lys Ala Ile Pro Glu Gly Glu Lys Ile Gln Gly Asp Gly Ala Gln 
    370                 375                 380                 


Ala Ala Val Lys Gly Ala Gln Ala Glu Leu Met Lys Val Gln Ala Leu 
385                 390                 395                 400 


Glu Lys Val Lys Gly Ala Asp Ile Asn Ala Glu Glu Ala Pro Lys Met 
                405                 410                 415     


Val Pro Lys Ala Val Glu Asp Gly Ile Lys Val Ala Asp Leu Glu Leu 
            420                 425                 430         


Glu Glu Gly Leu Ala Glu Glu Lys Leu Lys Xaa Val Glu Glu Ala Ala 
        435                 440                 445             


Ala Pro Arg Glu Gly Gln Gly Ser Ser Ala Val Gly Phe Glu Val Pro 
    450                 455                 460                 


Gln Gln Asp Val Ile Leu Pro Glu Tyr 
465                 470             


<210> 4846
<211> 343
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<400> 4846
Met Gln Pro Ser Cys Trp Gln Xaa Gln Pro Arg Gly Cys Cys Leu Leu 
1               5                   10                  15      


Pro Ala His Ile Tyr Ser Leu Phe Phe Ser Pro Ala Ile Arg Leu Leu 
            20                  25                  30          


Pro Ile Pro Cys Gly Cys Ala Lys Val Leu Asp Asp Pro Asn Glu Asp 
        35                  40                  45              


His Leu Tyr Met Val Phe Glu Leu Val Asn Gln Gly Pro Val Met Glu 
    50                  55                  60                  


Val Pro Xaa Leu Lys Pro Leu Ser Glu Asp Gln Ala Arg Phe Tyr Phe 
65                  70                  75                  80  


Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His Tyr Gln Lys Ile Ile 
                85                  90                  95      


His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val Gly Glu Asp Gly His 
            100                 105                 110         


Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu Phe Lys Gly Ser Asp 
        115                 120                 125             


Ala Leu Leu Ser Asn Xaa Val Gly Xaa Pro Ala Phe Met Ala Pro Glu 
    130                 135                 140                 


Ser Leu Ser Glu Xaa Arg Lys Ile Phe Ser Gly Lys Ala Leu Asp Val 
145                 150                 155                 160 


Trp Ala Met Gly Val Xaa Leu Tyr Cys Phe Val Phe Gly Gln Cys Pro 
                165                 170                 175     


Phe Met Asp Glu Arg Ile Met Cys Leu His Ser Lys Ile Lys Ser Gln 
            180                 185                 190         


Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala Glu Asp Leu Lys Asp 
        195                 200                 205             


Leu Ile Xaa Arg Met Leu Asp Lys Asn Pro Glu Ser Arg Ile Val Val 
    210                 215                 220                 


Pro Glu Ile Lys Leu His Pro Trp Val Xaa Arg His Gly Ala Glu Pro 
225                 230                 235                 240 


Leu Pro Ser Glu Asp Glu Asn Cys Xaa Leu Val Glu Val Xaa Glu Glu 
                245                 250                 255     


Glu Val Glu Asn Ser Val Lys His Ile Pro Ser Leu Ala Xaa Val Ile 
            260                 265                 270         


Leu Val Lys Xaa Met Ile Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu 
        275                 280                 285             


Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala Pro Gly Asn Leu Leu 
    290                 295                 300                 


Xaa Lys Lys Pro Xaa Arg Glu Cys Glu Ser Leu Ser Glu Leu Lys Gly 
305                 310                 315                 320 


Xaa Lys Lys Lys Lys Gly Leu Asp Ser Met Xaa Ser Xaa Val Ala Ala 
                325                 330                 335     


Gly Trp Leu Asp Arg Arg Val 
            340             


<210> 4847
<211> 87
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<400> 4847
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Xaa Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Xaa Ser Gly 
                85          


<210> 4848
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<400> 4848
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Xaa Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Xaa Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser 
        115                 120                 125 


<210> 4849
<211> 490
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<400> 4849
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Xaa Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Xaa Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Xaa Val Glu Ser His His Val Ser Ile Xaa Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Xaa Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Xaa Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Xaa Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Xaa Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Xaa Val Gly Xaa Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Xaa Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Xaa Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Xaa Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Ile Leu Val Lys Xaa Met Ile 
        435                 440                 445             


Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu 
    450                 455                 460                 


Arg Ser Leu Ser Ala Pro Gly Asn Leu Leu Xaa Lys Lys Pro Xaa Arg 
465                 470                 475                 480 


Glu Cys Glu Ser Leu Ser Glu Leu Lys Xaa 
                485                 490 


<210> 4850
<211> 498
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<400> 4850
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Xaa Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Xaa Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Xaa Val Glu Ser His His Val Ser Ile Xaa Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Xaa Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Xaa Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Xaa Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Xaa Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Xaa Val Gly Xaa Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Xaa Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Xaa Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Xaa Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Ile Leu Val Lys Xaa Met Ile 
        435                 440                 445             


Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu 
    450                 455                 460                 


Arg Ser Leu Ser Ala Pro Gly Asn Leu Leu Xaa Lys Gln Gly Ser Glu 
465                 470                 475                 480 


Asp Asn Leu Gln Gly Xaa Asp Pro Pro Pro Val Gly Glu Glu Glu Val 
                485                 490                 495     


Leu Leu 
        


<210> 4851
<211> 533
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<400> 4851
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Xaa Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Xaa Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Xaa Val Glu Ser His His Val Ser Ile Xaa Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Xaa Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Xaa Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Xaa Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Xaa Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Xaa Val Gly Xaa Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Xaa Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Xaa Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Xaa Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Xaa Arg 
        435                 440                 445             


His Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Xaa Leu Val 
    450                 455                 460                 


Glu Val Xaa Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser 
465                 470                 475                 480 


Leu Ala Xaa Val Ile Leu Val Lys Xaa Met Ile Arg Lys Arg Ser Phe 
                485                 490                 495     


Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala 
            500                 505                 510         


Pro Gly Asn Leu Leu Xaa Lys Lys Pro Xaa Arg Glu Cys Glu Ser Leu 
        515                 520                 525             


Ser Glu Leu Lys Xaa 
    530             


<210> 4852
<211> 541
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<400> 4852
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Xaa Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Xaa Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Xaa Val Glu Ser His His Val Ser Ile Xaa Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Xaa Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Xaa Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Xaa Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Xaa Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Xaa Val Gly Xaa Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Xaa Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Xaa Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Xaa Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Xaa Arg 
        435                 440                 445             


His Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Xaa Leu Val 
    450                 455                 460                 


Glu Val Xaa Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser 
465                 470                 475                 480 


Leu Ala Xaa Val Ile Leu Val Lys Xaa Met Ile Arg Lys Arg Ser Phe 
                485                 490                 495     


Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala 
            500                 505                 510         


Pro Gly Asn Leu Leu Xaa Lys Gln Gly Ser Glu Asp Asn Leu Gln Gly 
        515                 520                 525             


Xaa Asp Pro Pro Pro Val Gly Glu Glu Glu Val Leu Leu 
    530                 535                 540     


<210> 4853
<211> 545
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<400> 4853
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Xaa Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Xaa Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Xaa Val Glu Ser His His Val Ser Ile Xaa Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Xaa Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Xaa Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Xaa Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Xaa Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Xaa Val Gly Xaa Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Xaa Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Xaa Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Xaa Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Ile Leu Val Lys Xaa Met Ile 
        435                 440                 445             


Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu 
    450                 455                 460                 


Arg Ser Leu Ser Ala Pro Gly Asn Leu Leu Xaa Lys Lys Pro Xaa Arg 
465                 470                 475                 480 


Glu Cys Glu Ser Leu Ser Glu Leu Lys Glu Ala Arg Gln Arg Arg Gln 
                485                 490                 495     


Pro Pro Gly His Arg Pro Ala Pro Arg Gly Gly Gly Gly Ser Ala Leu 
            500                 505                 510         


Val Arg Gly Ser Pro Cys Val Glu Ser Cys Trp Ala Pro Ala Pro Gly 
        515                 520                 525             


Ser Pro Ala Arg Met His Pro Leu Arg Pro Glu Glu Ala Met Glu Pro 
    530                 535                 540                 


Glu 
545 


<210> 4854
<211> 556
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<400> 4854
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Xaa Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Xaa Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Xaa Val Glu Ser His His Val Ser Ile Xaa Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Xaa Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Xaa Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Xaa Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Xaa Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Xaa Val Gly Xaa Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Xaa Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Xaa Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Xaa Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Xaa Arg 
        435                 440                 445             


His Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Xaa Leu Val 
    450                 455                 460                 


Glu Val Xaa Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser 
465                 470                 475                 480 


Leu Ala Xaa Val Ile Leu Val Lys Xaa Met Ile Arg Lys Arg Ser Phe 
                485                 490                 495     


Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala 
            500                 505                 510         


Pro Gly Asn Leu Leu Xaa Lys Lys Pro Xaa Arg Glu Cys Glu Ser Leu 
        515                 520                 525             


Ser Glu Leu Lys Gly Xaa Lys Lys Lys Lys Gly Leu Asp Ser Met Xaa 
    530                 535                 540                 


Ser Xaa Val Ala Ala Gly Trp Leu Asp Arg Arg Val 
545                 550                 555     


<210> 4855
<211> 588
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<400> 4855
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Xaa Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Xaa Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Xaa Val Glu Ser His His Val Ser Ile Xaa Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Xaa Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Xaa Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Xaa Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Xaa Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Xaa Val Gly Xaa Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Xaa Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Xaa Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Xaa Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Xaa Arg 
        435                 440                 445             


His Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Xaa Leu Val 
    450                 455                 460                 


Glu Val Xaa Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser 
465                 470                 475                 480 


Leu Ala Xaa Val Ile Leu Val Lys Xaa Met Ile Arg Lys Arg Ser Phe 
                485                 490                 495     


Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala 
            500                 505                 510         


Pro Gly Asn Leu Leu Xaa Lys Lys Pro Xaa Arg Glu Cys Glu Ser Leu 
        515                 520                 525             


Ser Glu Leu Lys Glu Ala Arg Gln Arg Arg Gln Pro Pro Gly His Arg 
    530                 535                 540                 


Pro Ala Pro Arg Gly Gly Gly Gly Ser Ala Leu Val Arg Gly Ser Pro 
545                 550                 555                 560 


Cys Val Glu Ser Cys Trp Ala Pro Ala Pro Gly Ser Pro Ala Arg Met 
                565                 570                 575     


His Pro Leu Arg Pro Glu Glu Ala Met Glu Pro Glu 
            580                 585             


<210> 4856
<211> 197
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<400> 4856
Ile Trp Pro Ser Glu Glu Val Leu Ala Tyr Tyr Cys Leu Lys His Asn 
1               5                   10                  15      


Asn Ile Phe Arg Ala Leu Ala Val Cys Glu Leu Gly Gly Gly Met Xaa 
            20                  25                  30          


Cys Leu Ala Gly Leu Met Val Ala Ile Ser Ala Asp Val Lys Glu Val 
        35                  40                  45              


Leu Leu Xaa Asp Gly Asn Glu Lys Ala Ile Arg Asn Val Gln Asp Ile 
    50                  55                  60                  


Ile Xaa Arg Asn Gln Lys Ala Gly Val Phe Lys Xaa Gln Lys Ile Ser 
65                  70                  75                  80  


Ser Cys Val Leu Arg Trp Asp Asn Glu Xaa Asp Val Ser Gln Leu Glu 
                85                  90                  95      


Gly His Phe Asp Ile Val Met Cys Ala Asp Cys Leu Phe Leu Asp Gln 
            100                 105                 110         


Tyr Arg Ala Ser Leu Val Asp Ala Ile Lys Arg Leu Leu Gln Pro Arg 
        115                 120                 125             


Gly Lys Ala Met Val Phe Ala Pro Arg Arg Gly Asn Xaa Leu Asn Gln 
    130                 135                 140                 


Phe Cys Asn Leu Ala Glu Lys Ala Gly Phe Cys Ile Gln Arg His Glu 
145                 150                 155                 160 


Asn Tyr Asp Glu His Ile Ser Asn Phe His Ser Lys Leu Lys Lys Glu 
                165                 170                 175     


Asn Pro Asp Ile Tyr Glu Glu Asn Leu His Tyr Pro Leu Leu Leu Ile 
            180                 185                 190         


Leu Xaa Lys His Gly 
        195         


<210> 4857
<211> 323
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<400> 4857
Met Glu Ser Arg Val Ala Asp Ala Gly Xaa Gly Glu Xaa Ala Arg Ala 
1               5                   10                  15      


Ala Gly Gly Ser Pro Ala Val Gly Cys Xaa Xaa Arg Gly Pro Val Val 
            20                  25                  30          


Ser Ala Pro Leu Gly Ala Ala Arg Trp Lys Leu Leu Arg Gln Val Leu 
        35                  40                  45              


Lys Gln Lys His Leu Asp Asp Cys Leu Arg His Val Ser Val Arg Arg 
    50                  55                  60                  


Phe Glu Ser Phe Asn Leu Phe Ser Val Xaa Glu Gly Lys Glu Arg Glu 
65                  70                  75                  80  


Xaa Glu Glu Glu Val Gly Ala Trp Val Gln Tyr Xaa Ser Ile Phe Cys 
                85                  90                  95      


Pro Glu Tyr Ser Ile Ser Leu Arg His Asn Ser Gly Ser Leu Asn Val 
            100                 105                 110         


Glu Asp Val Leu Xaa Ser Phe Asp Asn Xaa Gly Asn Val Cys Ile Trp 
        115                 120                 125             


Pro Ser Glu Glu Val Leu Ala Tyr Tyr Cys Leu Lys His Asn Asn Ile 
    130                 135                 140                 


Phe Arg Ala Leu Ala Val Cys Glu Leu Gly Gly Gly Met Xaa Cys Leu 
145                 150                 155                 160 


Ala Gly Leu Met Val Ala Ile Ser Ala Asp Val Lys Glu Val Leu Leu 
                165                 170                 175     


Xaa Asp Gly Asn Glu Lys Ala Ile Arg Asn Val Gln Asp Ile Ile Xaa 
            180                 185                 190         


Arg Asn Gln Lys Ala Gly Val Phe Lys Xaa Gln Lys Ile Ser Ser Cys 
        195                 200                 205             


Val Leu Arg Trp Asp Asn Glu Xaa Asp Val Ser Gln Leu Glu Gly His 
    210                 215                 220                 


Phe Asp Ile Val Met Cys Ala Asp Cys Leu Phe Leu Asp Gln Tyr Arg 
225                 230                 235                 240 


Ala Ser Leu Val Asp Ala Ile Lys Arg Leu Leu Gln Pro Arg Gly Lys 
                245                 250                 255     


Ala Met Val Phe Ala Pro Arg Arg Gly Asn Xaa Leu Asn Gln Phe Cys 
            260                 265                 270         


Asn Leu Ala Glu Lys Ala Gly Phe Cys Ile Gln Arg His Glu Asn Tyr 
        275                 280                 285             


Asp Glu His Ile Ser Asn Phe His Ser Lys Leu Lys Lys Glu Asn Pro 
    290                 295                 300                 


Asp Ile Tyr Glu Glu Asn Leu His Tyr Pro Leu Leu Leu Ile Leu Xaa 
305                 310                 315                 320 


Lys His Gly 
            


<210> 4858
<211> 132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 4858
Met Glu Ser Arg Val Ala Asp Ala Gly Xaa Gly Glu Xaa Ala Arg Ala 
1               5                   10                  15      


Ala Gly Gly Ser Pro Ala Val Gly Cys Xaa Xaa Arg Gly Pro Val Val 
            20                  25                  30          


Ser Ala Pro Leu Gly Ala Ala Arg Trp Lys Leu Leu Arg Gln Val Leu 
        35                  40                  45              


Lys Gln Lys His Leu Asp Asp Cys Leu Arg His Val Ser Val Arg Arg 
    50                  55                  60                  


Phe Glu Ser Phe Asn Leu Phe Ser Val Xaa Glu Gly Lys Glu Arg Glu 
65                  70                  75                  80  


Xaa Glu Glu Glu Val Gly Ala Trp Val Gln Tyr Xaa Ser Ile Phe Cys 
                85                  90                  95      


Pro Glu Tyr Ser Ile Ser Leu Arg His Asn Ser Gly Ser Leu Asn Val 
            100                 105                 110         


Glu Asp Val Leu Xaa Ser Phe Asp Asn Xaa Gly Asn Val Trp Glu Ala 
        115                 120                 125             


Xaa Arg Gly Lys 
    130         


<210> 4859
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<400> 4859
Met Glu Ser Arg Val Ala Asp Ala Gly Xaa Gly Glu Xaa Ala Arg Ala 
1               5                   10                  15      


Ala Gly Gly Ser Pro Ala Val Gly Cys Xaa Xaa Arg Gly Pro Val Val 
            20                  25                  30          


Ser Ala Pro Leu Gly Ala Ala Arg Trp Lys Leu Leu Arg Gln Val Leu 
        35                  40                  45              


Lys Gln Lys His Leu Asp Asp Cys Leu Arg His Val Ser Val Arg Arg 
    50                  55                  60                  


Phe Glu Ser Phe Asn Leu Phe Ser Val Xaa Glu Gly Lys Glu Arg Glu 
65                  70                  75                  80  


Xaa Glu Glu Glu Val Gly Ala Trp Val Gln Tyr Xaa Ser Ile Phe Cys 
                85                  90                  95      


Pro Glu Tyr Ser Ile Ser Leu Arg His Asn Ser Gly Ser Leu Asn Val 
            100                 105                 110         


Glu Asp Val Leu Xaa Ser Phe Asp Asn Xaa Gly Asn Val Tyr Asp Val 
        115                 120                 125             


Ser Leu Tyr Cys Pro Cys Trp Ser 
    130                 135     


<210> 4860
<211> 139
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 4860
Met Glu Ser Arg Val Ala Asp Ala Gly Xaa Gly Glu Xaa Ala Arg Ala 
1               5                   10                  15      


Ala Gly Gly Ser Pro Ala Val Gly Cys Xaa Xaa Arg Gly Pro Val Val 
            20                  25                  30          


Ser Ala Pro Leu Gly Ala Ala Arg Trp Lys Leu Leu Arg Gln Val Leu 
        35                  40                  45              


Lys Gln Lys His Leu Asp Asp Cys Leu Arg His Val Ser Val Arg Arg 
    50                  55                  60                  


Phe Glu Ser Phe Asn Leu Phe Ser Val Xaa Glu Gly Lys Glu Arg Glu 
65                  70                  75                  80  


Xaa Glu Glu Glu Val Gly Ala Trp Val Gln Tyr Xaa Ser Ile Phe Cys 
                85                  90                  95      


Pro Glu Tyr Ser Ile Ser Leu Arg His Asn Ser Gly Ser Leu Asn Val 
            100                 105                 110         


Glu Asp Val Leu Xaa Ser Phe Asp Asn Xaa Gly Asn Val Tyr Xaa Gly 
        115                 120                 125             


Ser His Ser Val Ala Gln Ala Gly Val Gln Trp 
    130                 135                 


<210> 4861
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<400> 4861
Xaa Ala Pro Leu Gly Ala Ala Arg Trp Lys Leu Leu Arg Gln Val Leu 
1               5                   10                  15      


Lys Gln Lys His Leu Asp Asp Cys Leu Arg His Val Ser Val Arg Arg 
            20                  25                  30          


Phe Glu Ser Phe Asn Leu Phe Ser Val Xaa Glu Gly Lys Glu Arg Glu 
        35                  40                  45              


Xaa Glu Glu Glu Val Gly Ala Trp Val Gln Tyr Xaa Ser Ile Phe Cys 
    50                  55                  60                  


Pro Glu Tyr Ser Ile Ser Leu Arg His Asn Ser Gly Ser Leu Asn Val 
65                  70                  75                  80  


Glu Asp Val Leu Xaa Ser Phe Asp Asn Xaa Gly Asn Val 
                85                  90              


<210> 4862
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<400> 4862
Xaa Cys Leu Arg His Val Ser Val Arg Arg Phe Glu Ser Phe Asn Leu 
1               5                   10                  15      


Phe Ser Val Xaa Glu Gly Lys Glu Arg Glu Xaa Glu Glu Glu Val Gly 
            20                  25                  30          


Ala Trp Val Gln Tyr Xaa Ser Ile Phe Cys Pro Glu Tyr Ser Ile Ser 
        35                  40                  45              


Leu Arg His Asn Ser Gly Ser Leu Asn Val Glu Asp Val Leu Xaa Ser 
    50                  55                  60                  


Phe Asp Asn Xaa Gly Asn Val 
65                  70      


<210> 4863
<211> 83
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<400> 4863
Xaa Arg His Val Ser Val Arg Arg Phe Glu Ser Phe Asn Leu Phe Ser 
1               5                   10                  15      


Val Xaa Glu Gly Lys Glu Arg Glu Xaa Glu Glu Glu Val Gly Ala Trp 
            20                  25                  30          


Val Gln Tyr Xaa Ser Ile Phe Cys Pro Glu Tyr Ser Ile Ser Leu Arg 
        35                  40                  45              


His Asn Ser Gly Ser Leu Asn Val Glu Asp Val Leu Xaa Ser Phe Asp 
    50                  55                  60                  


Asn Xaa Gly Asn Val Tyr Xaa Gly Ser His Ser Val Ala Gln Ala Gly 
65                  70                  75                  80  


Val Gln Trp 
            


<210> 4864
<211> 296
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<400> 4864
Met Glu Ser Met Ala Val Ala Xaa Asp Gly Gly Glu Arg Pro Gly Val 
1               5                   10                  15      


Pro Ala Gly Ser Gly Leu Ser Ala Ser Gln Arg Arg Ala Glu Leu Arg 
            20                  25                  30          


Arg Arg Lys Leu Leu Met Asn Ser Glu Gln Arg Ile Asn Arg Ile Met 
        35                  40                  45              


Gly Phe His Arg Pro Gly Ser Gly Ala Glu Glu Glu Ser Gln Xaa Lys 
    50                  55                  60                  


Ser Lys Gln Gln Asp Ser Asp Lys Leu Asn Ser Leu Ser Val Pro Ser 
65                  70                  75                  80  


Val Ser Lys Arg Val Val Leu Gly Asp Ser Val Ser Xaa Gly Xaa Xaa 
                85                  90                  95      


Asp Gln Gln Gly Gly Val Ala Glu Val Lys Gly Xaa Gln Leu Gly Asp 
            100                 105                 110         


Lys Leu Asp Ser Phe Ile Lys Pro Pro Glu Cys Ser Ser Asp Val Asn 
        115                 120                 125             


Leu Glu Leu Arg Gln Arg Asn Arg Gly Asp Leu Xaa Ala Asp Ser Val 
    130                 135                 140                 


Gln Arg Gly Ser Arg His Gly Leu Glu Gln Tyr Leu Ser Arg Phe Glu 
145                 150                 155                 160 


Glu Ala Met Lys Leu Arg Lys Gln Leu Ile Ser Glu Lys Pro Ser Gln 
                165                 170                 175     


Glu Asp Gly Asn Xaa Xaa Glu Glu Phe Asp Ser Phe Arg Ile Phe Arg 
            180                 185                 190         


Leu Val Gly Cys Ala Leu Leu Ala Leu Gly Val Arg Ala Phe Val Cys 
        195                 200                 205             


Lys Tyr Leu Ser Ile Phe Ala Pro Phe Leu Xaa Leu Gln Leu Ala Tyr 
    210                 215                 220                 


Met Gly Leu Tyr Lys Tyr Phe Pro Lys Ser Glu Lys Lys Ile Lys Xaa 
225                 230                 235                 240 


Xaa Val Leu Xaa Ala Ala Leu Leu Leu Ser Gly Ile Pro Ala Glu Val 
                245                 250                 255     


Ile Asn Arg Ser Met Asp Xaa Tyr Ser Lys Met Gly Glu Val Phe Xaa 
            260                 265                 270         


Asp Leu Cys Val Tyr Phe Phe Xaa Phe Ile Phe Cys His Glu Leu Leu 
        275                 280                 285             


Asp Tyr Trp Gly Ser Glu Val Pro 
    290                 295     


<210> 4865
<211> 80
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(68)
<223> Selenocysteine

<400> 4865
Met Glu Ser Met Ala Val Ala Xaa Asp Gly Gly Glu Arg Pro Gly Val 
1               5                   10                  15      


Pro Ala Gly Ser Gly Leu Ser Ala Ser Gln Arg Arg Ala Glu Leu Arg 
            20                  25                  30          


Arg Arg Lys Leu Leu Met Asn Ser Glu Gln Arg Ile Asn Arg Ile Met 
        35                  40                  45              


Gly Phe His Arg Pro Gly Ser Gly Ala Val His Ile Cys Ser Ile Ser 
    50                  55                  60                  


Tyr Phe Xaa Xaa Cys Val His Gly Ile Ile Gln Ile Phe Ser Gln Glu 
65                  70                  75                  80  


<210> 4866
<211> 237
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<400> 4866
Met Ser Trp Leu Ala Ser Tyr Leu Ala Asp Ala Asp Cys Leu Pro Ser 
1               5                   10                  15      


Ala Ala Gln Ile Arg Ser Ala Tyr Asn Glu Pro Leu Xaa Pro Ser Ser 
            20                  25                  30          


Asn Xaa Ser Leu Ser Pro Val Gly Ser Pro Val Ser Glu Ile Ala Phe 
        35                  40                  45              


Glu Lys Pro Asn Leu Pro Ser Ala Ala Asp Trp Ser Glu Phe Leu Ser 
    50                  55                  60                  


Ala Ser Xaa Ser Glu Lys Val Glu Asn Glu Phe Ala Gln Leu Xaa Leu 
65                  70                  75                  80  


Ser Asp His Glu Gln Arg Glu Leu Tyr Glu Ala Ala Arg Leu Val Gln 
                85                  90                  95      


Xaa Ala Phe Arg Lys Tyr Lys Gly Arg Pro Leu Arg Glu Gln Gln Glu 
            100                 105                 110         


Val Ala Ala Ala Val Ile Gln Arg Cys Tyr Arg Lys Tyr Lys Gln Tyr 
        115                 120                 125             


Ala Leu Tyr Lys Lys Met Xaa Gln Ala Ala Ile Leu Ile Gln Ser Lys 
    130                 135                 140                 


Phe Arg Ser Tyr Tyr Glu Gln Lys Lys Phe Gln Gln Ser Arg Arg Ala 
145                 150                 155                 160 


Ala Val Leu Ile Gln Lys Tyr Tyr Arg Ser Tyr Lys Lys Cys Gly Lys 
                165                 170                 175     


Arg Arg Gln Ala Arg Arg Xaa Ala Val Ile Val Gln Gln Lys Leu Arg 
            180                 185                 190         


Ser Ser Leu Leu Xaa Lys Lys Gln Asp Gln Ala Ala Arg Lys Ile Met 
        195                 200                 205             


Arg Phe Leu Arg Arg Cys Arg His Arg Val Lys Glu Leu Lys Lys Ala 
    210                 215                 220                 


Lys Glu Leu Glu Asp Ile Gln Gln His Pro Leu Ala Met 
225                 230                 235         


<210> 4867
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 4867
Met Trp Arg Ala Glu Gly Lys Trp Leu Pro Lys Xaa Ser Arg Lys Ala 
1               5                   10                  15      


Gln Gly Arg Xaa Asp Pro Val Ser Val Leu Met Glu Leu Arg Gly Arg 
            20                  25                  30          


Arg Xaa Leu Ile Lys Met Pro Tyr Glu Ile Ser Ala Gly Xaa Gln Cys 
        35                  40                  45              


Cys Glu Asp Asp His Gly Asn Ser Asn Ser Ser His Val Lys Ile Phe 
    50                  55                  60                  


Leu Pro Lys Lys Leu Leu Glu Cys Leu Pro Lys Cys Ser Ser Leu Pro 
65                  70                  75                  80  


Lys Glu Arg His Arg Trp Asn Xaa Asn Glu Arg Ser 
                85                  90          


<210> 4868
<211> 101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<400> 4868
Met Trp Arg Ala Glu Gly Lys Trp Leu Pro Lys Xaa Ser Arg Lys Ser 
1               5                   10                  15      


Val Ser Gln Ser Val Phe Cys Gly Xaa Ser Xaa Tyr Cys Val Leu Asn 
            20                  25                  30          


Xaa Val Pro Pro Ile Glu Asp Asp His Gly Asn Ser Asn Ser Ser His 
        35                  40                  45              


Val Lys Ile Phe Leu Pro Lys Lys Leu Leu Glu Cys Leu Pro Lys Cys 
    50                  55                  60                  


Ser Ser Leu Pro Lys Glu Arg His Arg Trp Asn Xaa Asn Glu Ala Leu 
65                  70                  75                  80  


Xaa Xaa His Leu Phe Met Gly Ala Ala Lys Lys Arg Asp Pro Gln Ser 
                85                  90                  95      


Trp Ser His Glu Gly 
            100     


<210> 4869
<211> 1673
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1083)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1190)..(1190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1255)..(1255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1304)..(1304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1342)..(1342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1372)..(1372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1399)..(1399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1428)..(1428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1432)..(1432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1436)..(1436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1465)..(1465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1470)..(1470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1503)..(1503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1515)..(1515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1533)..(1533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1571)..(1571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1619)..(1619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1673)..(1673)
<223> Selenocysteine

<400> 4869
Met Trp Arg Ala Glu Gly Lys Trp Leu Pro Lys Xaa Ser Arg Lys Ser 
1               5                   10                  15      


Val Ser Gln Ser Val Phe Cys Gly Xaa Ser Xaa Tyr Cys Val Leu Asn 
            20                  25                  30          


Xaa Val Pro Pro Ile Glu Asp Asp His Gly Asn Ser Asn Ser Ser His 
        35                  40                  45              


Val Lys Ile Phe Leu Pro Lys Lys Leu Leu Glu Cys Leu Pro Lys Cys 
    50                  55                  60                  


Ser Ser Leu Pro Lys Glu Arg His Arg Trp Asn Xaa Asn Glu Glu Ile 
65                  70                  75                  80  


Ala Ala Tyr Leu Ile Xaa Phe Glu Lys His Glu Glu Trp Leu Xaa Xaa 
                85                  90                  95      


Ser Pro Lys Xaa Arg Pro Gln Asn Gly Ser Met Ile Leu Tyr Asn Arg 
            100                 105                 110         


Lys Lys Val Lys Tyr Arg Lys Asp Gly Tyr Cys Trp Lys Lys Arg Lys 
        115                 120                 125             


Asp Gly Lys Xaa Xaa Arg Glu Asp His Met Lys Leu Lys Val Gln Gly 
    130                 135                 140                 


Val Glu Cys Leu Tyr Gly Cys Tyr Val His Ser Ser Ile Ile Pro Xaa 
145                 150                 155                 160 


Phe His Arg Arg Cys Tyr Trp Leu Leu Gln Asn Pro Asp Ile Val Leu 
                165                 170                 175     


Val His Tyr Leu Asn Val Pro Ala Ile Glu Asp Cys Gly Lys Pro Cys 
            180                 185                 190         


Gly Pro Ile Leu Cys Ser Ile Asn Xaa Asp Lys Lys Glu Trp Ala Lys 
        195                 200                 205             


Trp Xaa Lys Glu Glu Leu Ile Gly Gln Leu Lys Pro Met Phe His Gly 
    210                 215                 220                 


Ile Lys Trp Xaa Cys Ser Asn Gly Asn Ser Ser Ser Gly Phe Ser Val 
225                 230                 235                 240 


Glu Gln Leu Val Gln Gln Ile Leu Asp Ser His Gln Xaa Lys Pro Gln 
                245                 250                 255     


Pro Arg Xaa His Asn Cys Leu Cys Xaa Gly Ser Leu Gly Ala Gly Gly 
            260                 265                 270         


Ser Val His His Lys Cys Asn Ser Ala Lys His Arg Ile Ile Ser Pro 
        275                 280                 285             


Lys Val Glu Pro Arg Xaa Gly Gly Tyr Gly Ser His Ser Glu Val Gln 
    290                 295                 300                 


His Asn Asp Val Ser Glu Gly Lys His Glu His Ser His Ser Lys Gly 
305                 310                 315                 320 


Ser Ser Arg Glu Lys Arg Asn Gly Lys Val Ala Lys Pro Val Leu Leu 
                325                 330                 335     


His Gln Ser Ser Xaa Glu Val Ser Ser Xaa Asn Gln Val Glu Val Pro 
            340                 345                 350         


Asp Xaa Xaa Gln Ser Ser Pro Val Ser Ile Ser Ser Gly Leu Asn Ser 
        355                 360                 365             


Asp Pro Asp Met Val Asp Ser Pro Val Val Xaa Gly Val Ser Gly Met 
    370                 375                 380                 


Ala Val Ala Ser Val Met Gly Ser Leu Ser Gln Ser Ala Xaa Val Phe 
385                 390                 395                 400 


Met Ser Glu Val Xaa Asn Glu Ala Val Tyr Xaa Met Ser Pro Xaa Ala 
                405                 410                 415     


Gly Pro Asn His His Leu Leu Ser Pro Asp Ala Ser Gln Gly Leu Val 
            420                 425                 430         


Leu Ala Val Ser Ser Asp Gly His Lys Phe Ala Phe Pro Xaa Xaa Gly 
        435                 440                 445             


Ser Ser Glu Ser Leu Ser Met Leu Pro Xaa Asn Val Ser Glu Glu Leu 
    450                 455                 460                 


Val Leu Ser Xaa Xaa Leu Asp Gly Gly Arg Lys Ile Pro Glu Xaa Xaa 
465                 470                 475                 480 


Met Asn Phe Asp Pro Asp Cys Phe Leu Asn Asn Pro Lys Gln Gly Gln 
                485                 490                 495     


Xaa Tyr Gly Gly Gly Gly Leu Lys Ala Glu Met Val Ser Ser Asn Ile 
            500                 505                 510         


Arg His Ser Pro Pro Gly Glu Arg Ser Phe Ser Phe Xaa Xaa Val Leu 
        515                 520                 525             


Xaa Lys Glu Ile Lys Xaa Glu Asp Xaa Ser Phe Glu Gln Gln Met Ala 
    530                 535                 540                 


Lys Glu Ala Tyr Ser Ser Ser Ala Ala Ala Val Ala Ala Ser Ser Leu 
545                 550                 555                 560 


Xaa Leu Xaa Ala Gly Ser Ser Leu Leu Pro Ser Gly Gly Gly Leu Ser 
                565                 570                 575     


Pro Ser Xaa Xaa Leu Glu Gln Met Asp Phe Ser Ala Ile Asp Ser Asn 
            580                 585                 590         


Lys Asp Tyr Xaa Ser Ser Phe Ser Gln Xaa Gly His Ser Pro His Ile 
        595                 600                 605             


His Gln Xaa Pro Ser Pro Ser Phe Phe Leu Gln Asp Ala Ser Lys Pro 
    610                 615                 620                 


Leu Pro Val Glu Gln Asn Xaa His Ser Ser Leu Ser Asp Ser Gly Gly 
625                 630                 635                 640 


Xaa Phe Val Met Pro Xaa Val Lys Xaa Glu Ala Ser Ser Gln Xaa Ser 
                645                 650                 655     


Ser Cys Ser Gly His Val Glu Xaa Arg Ile Glu Ser Xaa Ser Ser Leu 
            660                 665                 670         


His Leu Met Gln Phe Gln Ala Asn Phe Gln Ala Met Xaa Ala Glu Gly 
        675                 680                 685             


Glu Val Xaa Met Glu Xaa Ser Gln Ala Ala Glu Gly Ser Glu Val Leu 
    690                 695                 700                 


Leu Lys Ser Gly Glu Leu Gln Ala Cys Ser Ser Glu His Tyr Leu Gln 
705                 710                 715                 720 


Pro Glu Xaa Asn Gly Val Ile Arg Ser Ala Gly Gly Val Pro Ile Leu 
                725                 730                 735     


Pro Gly Asn Val Val Gln Gly Leu Tyr Pro Val Ala Gln Pro Ser Leu 
            740                 745                 750         


Gly Asn Ala Ser Asn Met Glu Leu Ser Leu Asp His Phe Asp Ile Ser 
        755                 760                 765             


Phe Ser Asn Gln Phe Ser Asp Leu Ile Asn Asp Phe Ile Ser Val Glu 
    770                 775                 780                 


Gly Gly Ser Ser Xaa Ile Tyr Gly His Gln Leu Val Ser Gly Asp Ser 
785                 790                 795                 800 


Xaa Ala Leu Ser Gln Ser Glu Asp Gly Ala Arg Ala Pro Phe Xaa Gln 
                805                 810                 815     


Ala Glu Met Cys Leu Pro Cys Cys Ser Pro Gln Gln Gly Ser Leu Gln 
            820                 825                 830         


Leu Ser Ser Ser Glu Gly Gly Ala Ser Xaa Met Ala Tyr Met His Val 
        835                 840                 845             


Ala Glu Val Val Ser Ala Ala Ser Ala Gln Gly Xaa Leu Gly Met Leu 
    850                 855                 860                 


Gln Gln Ser Gly Arg Val Phe Met Val Xaa Asp Tyr Ser Pro Glu Trp 
865                 870                 875                 880 


Ser Tyr Pro Glu Gly Gly Val Lys Val Leu Ile Xaa Gly Pro Trp Gln 
                885                 890                 895     


Glu Ala Ser Asn Asn Tyr Ser Cys Leu Phe Asp Gln Ile Ser Val Pro 
            900                 905                 910         


Ala Ser Leu Ile Gln Pro Gly Val Leu Arg Cys Tyr Cys Pro Ala His 
        915                 920                 925             


Asp Xaa Gly Leu Val Xaa Leu Gln Val Ala Phe Asn Asn Gln Ile Ile 
    930                 935                 940                 


Ser Asn Ser Val Val Phe Glu Tyr Lys Ala Arg Ala Leu Pro Xaa Leu 
945                 950                 955                 960 


Pro Ser Ser Gln His Asp Trp Leu Ser Leu Asp Asp Asn Gln Phe Arg 
                965                 970                 975     


Met Ser Ile Leu Glu Arg Leu Glu Gln Met Glu Arg Arg Met Ala Glu 
            980                 985                 990         


Met Xaa Gly Ser Gln Gln His Lys  Gln Ala Ser Gly Gly  Gly Ser Ser 
        995                 1000                 1005             


Gly Gly  Gly Ser Gly Ser Gly  Asn Gly Gly Ser Gln  Ala Gln Cys 
    1010                 1015                 1020             


Ala Ser  Gly Xaa Gly Ala Leu  Gly Ser Cys Phe Glu  Ser Arg Val 
    1025                 1030                 1035             


Val Val  Val Cys Glu Lys Met  Met Ser Arg Ala Cys  Trp Ala Lys 
    1040                 1045                 1050             


Ser Lys  His Leu Ile His Ser  Lys Xaa Phe Arg Gly  Met Xaa Leu 
    1055                 1060                 1065             


Leu His  Leu Ala Ala Ala Gln  Gly Tyr Ala Xaa Leu  Ile Gln Xaa 
    1070                 1075                 1080             


Leu Ile  Lys Trp Arg Xaa Lys  His Ala Asp Ser Ile  Asp Leu Glu 
    1085                 1090                 1095             


Leu Glu  Val Asp Pro Leu Asn  Val Asp His Phe Ser  Cys Xaa Pro 
    1100                 1105                 1110             


Leu Met  Trp Ala Cys Ala Leu  Gly His Leu Glu Ala  Ala Val Val 
    1115                 1120                 1125             


Leu Tyr  Lys Trp Asp Arg Arg  Ala Ile Ser Ile Pro  Asp Ser Leu 
    1130                 1135                 1140             


Gly Arg  Leu Pro Leu Gly Ile  Ala Arg Ser Arg Gly  His Val Lys 
    1145                 1150                 1155             


Leu Ala  Glu Cys Leu Glu His  Leu Gln Arg Asp Glu  Gln Ala Gln 
    1160                 1165                 1170             


Leu Gly  Gln Asn Pro Arg Ile  His Cys Pro Ala Ser  Glu Glu Pro 
    1175                 1180                 1185             


Ser Xaa  Glu Ser Trp Met Ala  Gln Trp His Ser Glu  Ala Ile Ser 
    1190                 1195                 1200             


Ser Pro  Glu Ile Pro Lys Gly  Val Xaa Val Ile Ala  Ser Xaa Asn 
    1205                 1210                 1215             


Pro Glu  Leu Arg Arg Pro Arg  Ser Glu Pro Ser Asn  Tyr Tyr Ser 
    1220                 1225                 1230             


Ser Glu  Ser His Lys Asp Tyr  Pro Ala Pro Lys Lys  His Lys Leu 
    1235                 1240                 1245             


Asn Pro  Glu Tyr Phe Gln Xaa  Arg Gln Glu Lys Leu  Leu Pro Xaa 
    1250                 1255                 1260             


Ala Leu  Ser Leu Glu Glu Pro  Asn Ile Arg Lys Gln  Ser Pro Ser 
    1265                 1270                 1275             


Ser Lys  Gln Ser Val Pro Glu  Xaa Leu Ser Pro Ser  Glu Gly Val 
    1280                 1285                 1290             


Arg Asp  Phe Ser Arg Glu Leu  Ser Pro Pro Xaa Pro  Glu Xaa Ala 
    1295                 1300                 1305             


Ala Phe  Gln Ala Ser Gly Ser  Gln Pro Val Gly Lys  Trp Asn Ser 
    1310                 1315                 1320             


Lys Asp  Leu Tyr Ile Gly Val  Ser Xaa Val Gln Val  Xaa Gly Asn 
    1325                 1330                 1335             


Pro Lys  Gly Xaa Ser Val Gly  Lys Glu Ala Ala Pro  Ser Gln Val 
    1340                 1345                 1350             


Arg Pro  Arg Glu Pro Met Ser  Val Leu Met Met Ala  Asn Arg Glu 
    1355                 1360                 1365             


Val Val  Asn Xaa Glu Leu Gly  Ser Tyr Arg Asp Ser  Ala Glu Asn 
    1370                 1375                 1380             


Glu Glu  Cys Gly Gln Pro Met  Asp Asp Ile Gln Val  Asn Met Met 
    1385                 1390                 1395             


Xaa Leu  Ala Glu His Ile Ile  Glu Ala Xaa Pro Asp  Arg Ile Lys 
    1400                 1405                 1410             


Gln Glu  Asn Phe Val Pro Met  Glu Ser Ser Gly Leu  Glu Arg Xaa 
    1415                 1420                 1425             


Asp Pro  Ala Xaa Ile Ser Ser  Xaa Met Ser Trp Leu  Ala Ser Tyr 
    1430                 1435                 1440             


Leu Ala  Asp Ala Asp Cys Leu  Pro Ser Ala Ala Gln  Ile Arg Ser 
    1445                 1450                 1455             


Ala Tyr  Asn Glu Pro Leu Xaa  Pro Ser Ser Asn Xaa  Ser Leu Ser 
    1460                 1465                 1470             


Pro Val  Gly Ser Pro Val Ser  Glu Ile Ala Phe Glu  Lys Pro Asn 
    1475                 1480                 1485             


Leu Pro  Ser Ala Ala Asp Trp  Ser Glu Phe Leu Ser  Ala Ser Xaa 
    1490                 1495                 1500             


Ser Glu  Lys Val Glu Asn Glu  Phe Ala Gln Leu Xaa  Leu Ser Asp 
    1505                 1510                 1515             


His Glu  Gln Arg Glu Leu Tyr  Glu Ala Ala Arg Leu  Val Gln Xaa 
    1520                 1525                 1530             


Ala Phe  Arg Lys Tyr Lys Gly  Arg Pro Leu Arg Glu  Gln Gln Glu 
    1535                 1540                 1545             


Val Ala  Ala Ala Val Ile Gln  Arg Cys Tyr Arg Lys  Tyr Lys Gln 
    1550                 1555                 1560             


Tyr Ala  Leu Tyr Lys Lys Met  Xaa Gln Ala Ala Ile  Leu Ile Gln 
    1565                 1570                 1575             


Ser Lys  Phe Arg Ser Tyr Tyr  Glu Gln Lys Lys Phe  Gln Gln Ser 
    1580                 1585                 1590             


Arg Arg  Ala Ala Val Leu Ile  Gln Lys Tyr Tyr Arg  Ser Tyr Lys 
    1595                 1600                 1605             


Lys Cys  Gly Lys Arg Arg Gln  Ala Arg Arg Xaa Ala  Val Ile Val 
    1610                 1615                 1620             


Gln Gln  Lys Leu Arg Ser Ser  Leu Leu Xaa Lys Lys  Gln Asp Gln 
    1625                 1630                 1635             


Ala Ala  Arg Lys Ile Met Arg  Phe Leu Arg Arg Cys  Arg His Ser 
    1640                 1645                 1650             


Pro Leu  Val Asp His Arg Leu  Tyr Lys Arg Ser Glu  Arg Ile Glu 
    1655                 1660                 1665             


Lys Gly  Gln Gly Xaa 
    1670             


<210> 4870
<211> 80
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<400> 4870
Met Trp Arg Ala Glu Gly Lys Trp Leu Pro Lys Xaa Ser Arg Lys Ser 
1               5                   10                  15      


Val Ser Gln Ser Val Phe Cys Gly Xaa Ser Xaa Tyr Cys Val Leu Asn 
            20                  25                  30          


Xaa Val Pro Pro Ile Glu Asp Asp His Gly Asn Ser Asn Ser Ser His 
        35                  40                  45              


Val Lys Ile Phe Leu Pro Lys Lys Leu Leu Glu Cys Leu Pro Lys Cys 
    50                  55                  60                  


Ser Ser Leu Pro Lys Glu Arg His Arg Trp Asn Xaa Asn Glu Arg Ser 
65                  70                  75                  80  


<210> 4871
<211> 73
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<400> 4871
Trp Leu Pro Lys Xaa Ser Arg Lys Ser Val Ser Gln Ser Val Phe Cys 
1               5                   10                  15      


Gly Xaa Ser Xaa Tyr Cys Val Leu Asn Xaa Val Pro Pro Ile Glu Asp 
            20                  25                  30          


Asp His Gly Asn Ser Asn Ser Ser His Val Lys Ile Phe Leu Pro Lys 
        35                  40                  45              


Lys Leu Leu Glu Cys Leu Pro Lys Cys Ser Ser Leu Pro Lys Glu Arg 
    50                  55                  60                  


His Arg Trp Asn Xaa Asn Glu Arg Ser 
65                  70              


<210> 4872
<211> 44
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<400> 4872
Xaa Gly Arg Xaa Asp Pro Val Ser Val Leu Met Glu Leu Arg Gly Arg 
1               5                   10                  15      


Arg Xaa Leu Ile Lys Met Pro Tyr Glu Ile Ser Ala Gly Xaa Gln Cys 
            20                  25                  30          


Cys Glu Glu Arg Phe Pro Lys Cys Ile Leu Arg Asn 
        35                  40                  


<210> 4873
<211> 637
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<400> 4873
Xaa Met Met Ser Arg Ala Cys Trp Ala Lys Ser Lys His Leu Ile His 
1               5                   10                  15      


Ser Lys Xaa Phe Arg Gly Met Xaa Leu Leu His Leu Ala Ala Ala Gln 
            20                  25                  30          


Gly Tyr Ala Xaa Leu Ile Gln Xaa Leu Ile Lys Trp Arg Xaa Lys His 
        35                  40                  45              


Ala Asp Ser Ile Asp Leu Glu Leu Glu Val Asp Pro Leu Asn Val Asp 
    50                  55                  60                  


His Phe Ser Cys Xaa Pro Leu Met Trp Ala Cys Ala Leu Gly His Leu 
65                  70                  75                  80  


Glu Ala Ala Val Val Leu Tyr Lys Trp Asp Arg Arg Ala Ile Ser Ile 
                85                  90                  95      


Pro Asp Ser Leu Gly Arg Leu Pro Leu Gly Ile Ala Arg Ser Arg Gly 
            100                 105                 110         


His Val Lys Leu Ala Glu Cys Leu Glu His Leu Gln Arg Asp Glu Gln 
        115                 120                 125             


Ala Gln Leu Gly Gln Asn Pro Arg Ile His Cys Pro Ala Ser Glu Glu 
    130                 135                 140                 


Pro Ser Xaa Glu Ser Trp Met Ala Gln Trp His Ser Glu Ala Ile Ser 
145                 150                 155                 160 


Ser Pro Glu Ile Pro Lys Gly Val Xaa Val Ile Ala Ser Xaa Asn Pro 
                165                 170                 175     


Glu Leu Arg Arg Pro Arg Ser Glu Pro Ser Asn Tyr Tyr Ser Ser Glu 
            180                 185                 190         


Ser His Lys Asp Tyr Pro Ala Pro Lys Lys His Lys Leu Asn Pro Glu 
        195                 200                 205             


Tyr Phe Gln Xaa Arg Gln Glu Lys Leu Leu Pro Xaa Ala Leu Ser Leu 
    210                 215                 220                 


Glu Glu Pro Asn Ile Arg Lys Gln Ser Pro Ser Ser Lys Gln Ser Val 
225                 230                 235                 240 


Pro Glu Xaa Leu Ser Pro Ser Glu Gly Val Arg Asp Phe Ser Arg Glu 
                245                 250                 255     


Leu Ser Pro Pro Xaa Pro Glu Xaa Ala Ala Phe Gln Ala Ser Gly Ser 
            260                 265                 270         


Gln Pro Val Gly Lys Trp Asn Ser Lys Asp Leu Tyr Ile Gly Val Ser 
        275                 280                 285             


Xaa Val Gln Val Xaa Gly Asn Pro Lys Gly Xaa Ser Val Gly Lys Glu 
    290                 295                 300                 


Ala Ala Pro Ser Gln Val Arg Pro Arg Glu Pro Met Ser Val Leu Met 
305                 310                 315                 320 


Met Ala Asn Arg Glu Val Val Asn Xaa Glu Leu Gly Ser Tyr Arg Asp 
                325                 330                 335     


Ser Ala Glu Asn Glu Glu Cys Gly Gln Pro Met Asp Asp Ile Gln Val 
            340                 345                 350         


Asn Met Met Xaa Leu Ala Glu His Ile Ile Glu Ala Xaa Pro Asp Arg 
        355                 360                 365             


Ile Lys Gln Glu Asn Phe Val Pro Met Glu Ser Ser Gly Leu Glu Arg 
    370                 375                 380                 


Xaa Asp Pro Ala Xaa Ile Ser Ser Xaa Met Ser Trp Leu Ala Ser Tyr 
385                 390                 395                 400 


Leu Ala Asp Ala Asp Cys Leu Pro Ser Ala Ala Gln Ile Arg Ser Ala 
                405                 410                 415     


Tyr Asn Glu Pro Leu Xaa Pro Ser Ser Asn Xaa Ser Leu Ser Pro Val 
            420                 425                 430         


Gly Ser Pro Val Ser Glu Ile Ala Phe Glu Lys Pro Asn Leu Pro Ser 
        435                 440                 445             


Ala Ala Asp Trp Ser Glu Phe Leu Ser Ala Ser Xaa Ser Glu Lys Val 
    450                 455                 460                 


Glu Asn Glu Phe Ala Gln Leu Xaa Leu Ser Asp His Glu Gln Arg Glu 
465                 470                 475                 480 


Leu Tyr Glu Ala Ala Arg Leu Val Gln Xaa Ala Phe Arg Lys Tyr Lys 
                485                 490                 495     


Gly Arg Pro Leu Arg Glu Gln Gln Glu Val Ala Ala Ala Val Ile Gln 
            500                 505                 510         


Arg Cys Tyr Arg Lys Tyr Lys Gln Leu Xaa Trp Ile Ala Leu Lys Tyr 
        515                 520                 525             


Ala Leu Tyr Lys Lys Met Xaa Gln Ala Ala Ile Leu Ile Gln Ser Lys 
    530                 535                 540                 


Phe Arg Ser Tyr Tyr Glu Gln Lys Lys Phe Gln Gln Ser Arg Arg Ala 
545                 550                 555                 560 


Ala Val Leu Ile Gln Lys Tyr Tyr Arg Ser Tyr Lys Lys Cys Gly Lys 
                565                 570                 575     


Arg Arg Gln Ala Arg Arg Xaa Ala Val Ile Val Gln Gln Lys Leu Arg 
            580                 585                 590         


Ser Ser Leu Leu Xaa Lys Lys Gln Asp Gln Ala Ala Arg Lys Ile Met 
        595                 600                 605             


Arg Phe Leu Arg Arg Cys Arg His Arg Val Lys Glu Leu Lys Lys Ala 
    610                 615                 620                 


Lys Glu Leu Glu Asp Ile Gln Gln His Pro Leu Ala Met 
625                 630                 635         


<210> 4874
<211> 239
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<400> 4874
Xaa Ser Ser Gly Leu Glu Arg Xaa Asp Pro Ala Xaa Ile Ser Ser Xaa 
1               5                   10                  15      


Met Ser Trp Leu Ala Ser Tyr Leu Ala Asp Ala Asp Cys Leu Pro Ser 
            20                  25                  30          


Ala Ala Gln Ile Arg Leu Ser Pro Val Gly Ser Pro Val Ser Glu Ile 
        35                  40                  45              


Ala Phe Glu Lys Pro Asn Leu Pro Ser Ala Ala Asp Trp Ser Glu Phe 
    50                  55                  60                  


Leu Ser Ala Ser Xaa Ser Glu Lys Val Glu Asn Glu Phe Ala Gln Leu 
65                  70                  75                  80  


Xaa Leu Ser Asp His Glu Gln Arg Glu Leu Tyr Glu Ala Ala Arg Leu 
                85                  90                  95      


Val Gln Xaa Ala Phe Arg Lys Tyr Lys Gly Arg Pro Leu Arg Glu Gln 
            100                 105                 110         


Gln Glu Val Ala Ala Ala Val Ile Gln Arg Cys Tyr Arg Lys Tyr Lys 
        115                 120                 125             


Gln Tyr Ala Leu Tyr Lys Lys Met Xaa Gln Ala Ala Ile Leu Ile Gln 
    130                 135                 140                 


Ser Lys Phe Arg Ser Tyr Tyr Glu Gln Lys Lys Phe Gln Gln Ser Arg 
145                 150                 155                 160 


Arg Ala Ala Val Leu Ile Gln Lys Tyr Tyr Arg Ser Tyr Lys Lys Cys 
                165                 170                 175     


Gly Lys Arg Arg Gln Ala Arg Arg Xaa Ala Val Ile Val Gln Gln Lys 
            180                 185                 190         


Leu Arg Ser Ser Leu Leu Xaa Lys Lys Gln Asp Gln Ala Ala Arg Lys 
        195                 200                 205             


Ile Met Arg Phe Leu Arg Arg Cys Arg His Arg Val Lys Glu Leu Lys 
    210                 215                 220                 


Lys Ala Lys Glu Leu Glu Asp Ile Gln Gln His Pro Leu Ala Met 
225                 230                 235                 


<210> 4875
<211> 39
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<400> 4875
Xaa Ser Ser His Val Lys Ile Phe Leu Pro Lys Lys Leu Leu Glu Cys 
1               5                   10                  15      


Leu Pro Lys Cys Ser Ser Leu Pro Lys Glu Arg His Arg Trp Asn Xaa 
            20                  25                  30          


Asn Glu Val Leu Lys Phe Trp 
        35                  


<210> 4876
<211> 178
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 4876
Lys Asp Xaa Xaa Glu Val Ala Glu Asn Ser His His Leu Lys Ile Phe 
1               5                   10                  15      


Leu Pro Lys Lys Leu Leu Glu Cys Leu Pro Arg Cys Pro Leu Leu Pro 
            20                  25                  30          


Pro Glu Arg Leu Arg Trp Asn Xaa Asn Glu Glu Ile Ala Ser Tyr Leu 
        35                  40                  45              


Ile Xaa Phe Glu Lys His Asp Glu Trp Leu Ser Cys Ala Pro Lys Xaa 
    50                  55                  60                  


Arg Pro Gln Asn Gly Ser Ile Ile Leu Tyr Asn Arg Lys Lys Val Lys 
65                  70                  75                  80  


Tyr Arg Lys Asp Gly Tyr Leu Trp Lys Lys Arg Lys Asp Gly Lys Xaa 
                85                  90                  95      


Xaa Arg Glu Asp His Met Lys Leu Lys Val Gln Gly Met Glu Gln Arg 
            100                 105                 110         


Pro Ser Arg Val Ala Glu Val Val Pro Gly Gly Val Val Gly Xaa Ala 
        115                 120                 125             


Glu Ala His Val Ser Trp His Gln Val Glu Leu Arg Glu Trp Asn Arg 
    130                 135                 140                 


Arg Val Leu Cys Arg Xaa Pro Gly Ala Ala Asp Phe Gly His Pro Pro 
145                 150                 155                 160 


Asn Gln Ala Cys Ser Pro Asn Pro Arg Leu Ser Leu Gln Trp Gly Ala 
                165                 170                 175     


Trp Phe 
        


<210> 4877
<211> 1197
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (983)..(983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1197)..(1197)
<223> Selenocysteine

<400> 4877
Met Ala Ala Ala Ala Val Xaa Arg Gly Xaa Pro Gly Glu Asn Ser His 
1               5                   10                  15      


His Leu Lys Ile Phe Leu Pro Lys Lys Leu Leu Glu Cys Leu Pro Arg 
            20                  25                  30          


Cys Pro Leu Leu Pro Pro Glu Arg Leu Arg Trp Asn Xaa Asn Glu Glu 
        35                  40                  45              


Ile Ala Ser Tyr Leu Ile Xaa Phe Glu Lys His Asp Glu Trp Leu Ser 
    50                  55                  60                  


Cys Ala Pro Lys Xaa Arg Pro Gln Asn Gly Ser Ile Ile Leu Tyr Asn 
65                  70                  75                  80  


Arg Lys Lys Val Lys Tyr Arg Lys Asp Gly Tyr Leu Trp Lys Lys Arg 
                85                  90                  95      


Lys Asp Gly Lys Xaa Xaa Arg Glu Asp His Met Lys Leu Lys Val Gln 
            100                 105                 110         


Gly Met Glu Cys Leu Tyr Gly Cys Tyr Val His Ser Ser Ile Val Pro 
        115                 120                 125             


Xaa Phe His Arg Arg Cys Tyr Trp Leu Leu Gln Asn Pro Asp Ile Val 
    130                 135                 140                 


Leu Val His Tyr Leu Asn Val Pro Ala Leu Glu Asp Cys Gly Lys Gly 
145                 150                 155                 160 


Cys Ser Pro Ile Phe Cys Ser Ile Ser Ser Asp Arg Arg Glu Trp Leu 
                165                 170                 175     


Lys Trp Ser Arg Glu Glu Leu Leu Gly Gln Leu Lys Pro Met Phe His 
            180                 185                 190         


Gly Ile Lys Trp Ser Cys Gly Asn Gly Xaa Glu Glu Phe Ser Val Glu 
        195                 200                 205             


His Leu Val Gln Gln Ile Leu Asp Xaa His Pro Xaa Lys Pro Ala Pro 
    210                 215                 220                 


Arg Xaa His Ala Cys Leu Cys Ser Gly Gly Leu Gly Ser Gly Ser Leu 
225                 230                 235                 240 


Xaa His Lys Cys Ser Ser Xaa Lys His Arg Ile Ile Ser Pro Lys Val 
                245                 250                 255     


Glu Pro Arg Ala Leu Xaa Leu Xaa Ser Ile Pro His Ala His Pro Pro 
            260                 265                 270         


Glu Pro Pro Pro Leu Ile Ala Pro Leu Pro Pro Glu Leu Pro Lys Ala 
        275                 280                 285             


His Xaa Ser Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Phe Ala 
    290                 295                 300                 


Glu Pro Leu Glu Ile Arg Pro Ser Pro Pro Xaa Ser Arg Gly Gly Ser 
305                 310                 315                 320 


Ser Arg Gly Gly Xaa Ala Ile Leu Leu Leu Xaa Gly Leu Glu Gln Arg 
                325                 330                 335     


Ala Gly Gly Leu Xaa Pro Xaa Arg His Leu Ala Pro Gln Ala Asp Pro 
            340                 345                 350         


Arg Pro Ser Met Ser Leu Ala Val Val Val Gly Xaa Glu Pro Ser Ala 
        355                 360                 365             


Pro Pro Ala Pro Pro Ser Pro Ala Phe Asp Pro Asp Arg Phe Leu Asn 
    370                 375                 380                 


Ser Pro Gln Arg Gly Gln Xaa Tyr Gly Gly Gly Gln Gly Val Ser Pro 
385                 390                 395                 400 


Asp Phe Pro Glu Ala Glu Ala Ala His Xaa Pro Cys Ser Ala Leu Glu 
                405                 410                 415     


Pro Ala Ala Ala Leu Glu Pro Gln Ala Ala Ala Arg Gly Pro Pro Pro 
            420                 425                 430         


Gln Ser Val Ala Gly Gly Arg Arg Gly Asn Cys Phe Phe Ile Gln Asp 
        435                 440                 445             


Asp Asp Ser Gly Glu Glu Leu Lys Gly His Gly Ala Ala Pro Pro Ile 
    450                 455                 460                 


Pro Ser Pro Pro Pro Ser Pro Pro Pro Ser Pro Ala Pro Leu Glu Pro 
465                 470                 475                 480 


Ser Ser Arg Val Gly Arg Gly Glu Ala Leu Phe Gly Gly Pro Val Gly 
                485                 490                 495     


Ala Ser Glu Leu Glu Pro Phe Ser Leu Ser Ser Phe Pro Asp Leu Met 
            500                 505                 510         


Gly Glu Leu Ile Ser Asp Glu Ala Pro Ser Ile Pro Ala Pro Xaa Pro 
        515                 520                 525             


Gln Leu Ser Pro Ala Leu Ser Xaa Ile Xaa Asp Phe Ser Pro Glu Trp 
    530                 535                 540                 


Ser Tyr Pro Glu Gly Gly Val Lys Val Leu Ile Xaa Gly Pro Trp Xaa 
545                 550                 555                 560 


Glu Ala Ala Glu His Tyr Ser Cys Val Phe Asp His Ile Ala Val Pro 
                565                 570                 575     


Ala Ser Leu Val Gln Pro Gly Val Leu Arg Cys Tyr Cys Pro Ala His 
            580                 585                 590         


Glu Val Gly Leu Val Ser Leu Gln Val Ala Gly Arg Glu Gly Pro Leu 
        595                 600                 605             


Ser Ala Ser Val Leu Phe Glu Tyr Arg Ala Arg Arg Phe Leu Ser Leu 
    610                 615                 620                 


Pro Ser Xaa Gln Leu Asp Trp Leu Ser Leu Asp Asp Asn Gln Phe Arg 
625                 630                 635                 640 


Met Ser Ile Leu Glu Arg Leu Glu Gln Met Glu Lys Arg Met Ala Glu 
                645                 650                 655     


Ile Ala Ala Ala Gly Gln Val Pro Cys Gln Gly Pro Asp Ala Pro Pro 
            660                 665                 670         


Val Gln Asp Glu Gly Gln Gly Pro Gly Phe Glu Ala Arg Val Val Val 
        675                 680                 685             


Leu Val Glu Ser Met Ile Pro Arg Ser Xaa Trp Lys Gly Pro Glu Arg 
    690                 695                 700                 


Leu Ala His Gly Ser Pro Phe Arg Gly Met Ser Leu Leu His Leu Ala 
705                 710                 715                 720 


Ala Ala Gln Gly Tyr Ala Arg Leu Ile Glu Xaa Leu Ser Gln Trp Arg 
                725                 730                 735     


Ser Val Glu Xaa Gly Ser Leu Asp Leu Glu Gln Glu Val Asp Pro Leu 
            740                 745                 750         


Asn Val Asp His Phe Ser Cys Xaa Pro Leu Met Trp Ala Cys Ala Leu 
        755                 760                 765             


Gly His Leu Glu Ala Ala Val Leu Leu Phe Arg Trp Asn Arg Gln Ala 
    770                 775                 780                 


Leu Ser Ile Pro Asp Ser Leu Gly Arg Leu Pro Leu Ser Val Ala His 
785                 790                 795                 800 


Ser Arg Gly His Val Arg Leu Ala Arg Cys Leu Glu Glu Leu Gln Arg 
                805                 810                 815     


Gln Glu Pro Ser Val Glu Pro Pro Phe Ala Leu Ser Pro Pro Ser Ser 
            820                 825                 830         


Ser Pro Asp Xaa Gly Leu Ser Ser Val Ser Ser Pro Ser Glu Leu Ser 
        835                 840                 845             


Asp Gly Xaa Phe Ser Val Xaa Ser Ala Tyr Ser Ser Ala Pro Asp Gly 
    850                 855                 860                 


Ser Pro Pro Pro Ala Pro Leu Pro Ala Ser Glu Met Xaa Met Glu Asp 
865                 870                 875                 880 


Met Ala Pro Gly Gln Leu Ser Ser Gly Val Pro Glu Ala Pro Leu Leu 
                885                 890                 895     


Leu Met Asp Tyr Glu Ala Xaa Asn Ser Lys Gly Pro Leu Ser Ser Leu 
            900                 905                 910         


Pro Ala Leu Pro Pro Ala Ser Asp Asp Gly Ala Ala Pro Glu Asp Ala 
        915                 920                 925             


Asp Ser Pro Gln Ala Val Asp Val Ile Pro Val Asp Met Ile Ser Leu 
    930                 935                 940                 


Ala Lys Gln Ile Ile Glu Ala Xaa Pro Glu Arg Ile Lys Arg Glu Asp 
945                 950                 955                 960 


Phe Val Gly Leu Pro Glu Ala Gly Ala Ser Met Arg Glu Arg Xaa Gly 
                965                 970                 975     


Ala Val Gly Leu Ser Glu Xaa Met Ser Trp Leu Ala Ser Tyr Leu Glu 
            980                 985                 990         


Asn Val Asp His Phe Pro Ser Ser  Xaa Pro Pro Ser Glu  Leu Pro Phe 
        995                 1000                 1005             


Glu Arg  Gly Arg Leu Ala Val  Pro Ser Ala Pro Ser  Trp Ala Glu 
    1010                 1015                 1020             


Phe Leu  Ser Ala Ser Xaa Ser  Gly Lys Met Glu Ser  Asp Phe Ala 
    1025                 1030                 1035             


Leu Leu  Xaa Leu Ser Asp His  Glu Gln Arg Glu Leu  Tyr Glu Ala 
    1040                 1045                 1050             


Ala Arg  Val Ile Gln Xaa Ala  Phe Arg Lys Tyr Lys  Gly Arg Arg 
    1055                 1060                 1065             


Leu Lys  Glu Gln Gln Glu Val  Ala Ala Ala Val Ile  Gln Arg Cys 
    1070                 1075                 1080             


Tyr Arg  Lys Tyr Lys Gln Phe  Ala Leu Tyr Lys Lys  Met Xaa Gln 
    1085                 1090                 1095             


Ala Ala  Ile Leu Ile Gln Ser  Lys Phe Arg Ser Tyr  Tyr Glu Gln 
    1100                 1105                 1110             


Lys Arg  Phe Gln Gln Ser Arg  Arg Ala Ala Val Leu  Ile Gln Gln 
    1115                 1120                 1125             


His Tyr  Arg Ser Tyr Arg Arg  Arg Pro Gly Pro Pro  His Arg Xaa 
    1130                 1135                 1140             


Ser Ala  Xaa Leu Pro Ala Arg  Asn Lys Gly Ser Phe  Leu Xaa Lys 
    1145                 1150                 1155             


Lys Gln  Asp Gln Ala Ala Arg  Lys Ile Met Arg Phe  Leu Arg Arg 
    1160                 1165                 1170             


Cys Arg  His Arg Met Arg Glu  Leu Lys Gln Asn Gln  Glu Leu Glu 
    1175                 1180                 1185             


Gly Leu  Pro Gln Pro Gly Leu  Ala Xaa 
    1190                 1195         


<210> 4878
<211> 163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<400> 4878
Met Ala Ala Ala Ala Val Xaa Arg Gly Xaa Pro Gly Glu Asn Ser His 
1               5                   10                  15      


His Leu Lys Ile Phe Leu Pro Lys Lys Leu Leu Glu Cys Leu Pro Arg 
            20                  25                  30          


Cys Pro Leu Leu Pro Pro Glu Arg Leu Arg Trp Asn Xaa Asn Glu Glu 
        35                  40                  45              


Ile Ala Ser Tyr Leu Ile Xaa Phe Glu Lys His Asp Glu Trp Leu Ser 
    50                  55                  60                  


Cys Ala Pro Lys Xaa Arg Pro Gln Asn Gly Ser Ile Ile Leu Tyr Asn 
65                  70                  75                  80  


Arg Lys Lys Val Lys Tyr Arg Lys Asp Gly Tyr Leu Trp Lys Lys Arg 
                85                  90                  95      


Lys Asp Gly Lys Xaa Xaa Arg Glu Asp His Met Lys Leu Lys Val Gln 
            100                 105                 110         


Gly Met Glu Gly Leu Asn Arg Gly Arg Val Gly Glu Gln Xaa Ser Pro 
        115                 120                 125             


Pro Pro Xaa Pro Ala Cys Leu Leu Ala Val Ser Leu Trp Leu Leu Arg 
    130                 135                 140                 


Ser Leu Phe His Arg Pro His Ile Pro Ser Ala Leu Leu Leu Ala Ala 
145                 150                 155                 160 


Pro Glu Pro 
            


<210> 4879
<211> 1241
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (996)..(996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1208)..(1208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1222)..(1222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1226)..(1226)
<223> Selenocysteine

<400> 4879
Met Gly Xaa Asp Ser Pro Ser Pro Arg Pro Leu Arg Pro Gly Val Xaa 
1               5                   10                  15      


Leu Pro Pro Gly Ala Leu Xaa Met Asn Xaa Lys Asp Xaa Xaa Glu Val 
            20                  25                  30          


Ala Glu Asn Ser His His Leu Lys Ile Phe Leu Pro Lys Lys Leu Leu 
        35                  40                  45              


Glu Cys Leu Pro Arg Cys Pro Leu Leu Pro Pro Glu Arg Leu Arg Trp 
    50                  55                  60                  


Asn Xaa Asn Glu Glu Ile Ala Ser Tyr Leu Ile Xaa Phe Glu Lys His 
65                  70                  75                  80  


Asp Glu Trp Leu Ser Cys Ala Pro Lys Xaa Arg Pro Gln Asn Gly Ser 
                85                  90                  95      


Ile Ile Leu Tyr Asn Arg Lys Lys Val Lys Tyr Arg Lys Asp Gly Tyr 
            100                 105                 110         


Leu Trp Lys Lys Arg Lys Asp Gly Lys Xaa Xaa Arg Glu Asp His Met 
        115                 120                 125             


Lys Leu Lys Val Gln Gly Met Glu Cys Leu Tyr Gly Cys Tyr Val His 
    130                 135                 140                 


Ser Ser Ile Val Pro Xaa Phe His Arg Arg Cys Tyr Trp Leu Leu Gln 
145                 150                 155                 160 


Asn Pro Asp Ile Val Leu Val His Tyr Leu Asn Val Pro Ala Leu Glu 
                165                 170                 175     


Asp Cys Gly Lys Gly Cys Ser Pro Ile Phe Cys Ser Ile Ser Ser Asp 
            180                 185                 190         


Arg Arg Glu Trp Leu Lys Trp Ser Arg Glu Glu Leu Leu Gly Gln Leu 
        195                 200                 205             


Lys Pro Met Phe His Gly Ile Lys Trp Ser Cys Gly Asn Gly Xaa Glu 
    210                 215                 220                 


Glu Phe Ser Val Glu His Leu Val Gln Gln Ile Leu Asp Xaa His Pro 
225                 230                 235                 240 


Xaa Lys Pro Ala Pro Arg Xaa His Ala Cys Leu Cys Ser Gly Gly Leu 
                245                 250                 255     


Gly Ser Gly Ser Leu Xaa His Lys Cys Ser Ser Xaa Lys His Arg Ile 
            260                 265                 270         


Ile Ser Pro Lys Val Glu Pro Arg Ala Leu Xaa Leu Xaa Ser Ile Pro 
        275                 280                 285             


His Ala His Pro Pro Glu Pro Pro Pro Leu Ile Ala Pro Leu Pro Pro 
    290                 295                 300                 


Glu Leu Pro Lys Ala His Xaa Ser Pro Ser Ser Ser Ser Ser Ser Ser 
305                 310                 315                 320 


Ser Ser Gly Phe Ala Glu Pro Leu Glu Ile Arg Pro Ser Pro Pro Xaa 
                325                 330                 335     


Ser Arg Gly Gly Ser Ser Arg Gly Gly Xaa Ala Ile Leu Leu Leu Xaa 
            340                 345                 350         


Gly Leu Glu Gln Arg Ala Gly Gly Leu Xaa Pro Xaa Arg His Leu Ala 
        355                 360                 365             


Pro Gln Ala Asp Pro Arg Pro Ser Met Ser Leu Ala Val Val Val Gly 
    370                 375                 380                 


Xaa Glu Pro Ser Ala Pro Pro Ala Pro Pro Ser Pro Ala Phe Asp Pro 
385                 390                 395                 400 


Asp Arg Phe Leu Asn Ser Pro Gln Arg Gly Gln Xaa Tyr Gly Gly Gly 
                405                 410                 415     


Gln Gly Val Ser Pro Asp Phe Pro Glu Ala Glu Ala Ala His Xaa Pro 
            420                 425                 430         


Cys Ser Ala Leu Glu Pro Ala Ala Ala Leu Glu Pro Gln Ala Ala Ala 
        435                 440                 445             


Arg Gly Pro Pro Pro Gln Ser Val Ala Gly Gly Arg Arg Gly Asn Cys 
    450                 455                 460                 


Phe Phe Ile Gln Asp Asp Asp Ser Gly Glu Glu Leu Lys Gly His Gly 
465                 470                 475                 480 


Ala Ala Pro Pro Ile Pro Ser Pro Pro Pro Ser Pro Pro Pro Ser Pro 
                485                 490                 495     


Ala Pro Leu Glu Pro Ser Ser Arg Val Gly Arg Gly Glu Ala Leu Phe 
            500                 505                 510         


Gly Gly Pro Val Gly Ala Ser Glu Leu Glu Pro Phe Ser Leu Ser Ser 
        515                 520                 525             


Phe Pro Asp Leu Met Gly Glu Leu Ile Ser Asp Glu Ala Pro Ser Ile 
    530                 535                 540                 


Pro Ala Pro Xaa Pro Gln Leu Ser Pro Ala Leu Ser Xaa Ile Xaa Asp 
545                 550                 555                 560 


Phe Ser Pro Glu Trp Ser Tyr Pro Glu Gly Gly Val Lys Val Leu Ile 
                565                 570                 575     


Xaa Gly Pro Trp Xaa Glu Ala Ala Glu His Tyr Ser Cys Val Phe Asp 
            580                 585                 590         


His Ile Ala Val Pro Ala Ser Leu Val Gln Pro Gly Val Leu Arg Cys 
        595                 600                 605             


Tyr Cys Pro Ala His Glu Val Gly Leu Val Ser Leu Gln Val Ala Gly 
    610                 615                 620                 


Arg Glu Gly Pro Leu Ser Ala Ser Val Leu Phe Glu Tyr Arg Ala Arg 
625                 630                 635                 640 


Arg Phe Leu Ser Leu Pro Ser Xaa Gln Leu Asp Trp Leu Ser Leu Asp 
                645                 650                 655     


Asp Asn Gln Phe Arg Met Ser Ile Leu Glu Arg Leu Glu Gln Met Glu 
            660                 665                 670         


Lys Arg Met Ala Glu Ile Ala Ala Ala Gly Gln Val Pro Cys Gln Gly 
        675                 680                 685             


Pro Asp Ala Pro Pro Val Gln Asp Glu Gly Gln Gly Pro Gly Phe Glu 
    690                 695                 700                 


Ala Arg Val Val Val Leu Val Glu Ser Met Ile Pro Arg Ser Xaa Trp 
705                 710                 715                 720 


Lys Gly Pro Glu Arg Leu Ala His Gly Ser Pro Phe Arg Gly Met Ser 
                725                 730                 735     


Leu Leu His Leu Ala Ala Ala Gln Gly Tyr Ala Arg Leu Ile Glu Xaa 
            740                 745                 750         


Leu Ser Gln Trp Arg Ser Val Glu Xaa Gly Ser Leu Asp Leu Glu Gln 
        755                 760                 765             


Glu Val Asp Pro Leu Asn Val Asp His Phe Ser Cys Xaa Pro Leu Met 
    770                 775                 780                 


Trp Ala Cys Ala Leu Gly His Leu Glu Ala Ala Val Leu Leu Phe Arg 
785                 790                 795                 800 


Trp Asn Arg Gln Ala Leu Ser Ile Pro Asp Ser Leu Gly Arg Leu Pro 
                805                 810                 815     


Leu Ser Val Ala His Ser Arg Gly His Val Arg Leu Ala Arg Cys Leu 
            820                 825                 830         


Glu Glu Leu Gln Arg Gln Glu Pro Ser Val Glu Pro Pro Phe Ala Leu 
        835                 840                 845             


Ser Pro Pro Ser Ser Ser Pro Asp Xaa Gly Leu Ser Ser Val Ser Ser 
    850                 855                 860                 


Pro Ser Glu Leu Ser Asp Gly Xaa Phe Ser Val Xaa Ser Ala Tyr Ser 
865                 870                 875                 880 


Ser Ala Pro Asp Gly Ser Pro Pro Pro Ala Pro Leu Pro Ala Ser Glu 
                885                 890                 895     


Met Xaa Met Glu Asp Met Ala Pro Gly Gln Leu Ser Ser Gly Val Pro 
            900                 905                 910         


Glu Ala Pro Leu Leu Leu Met Asp Tyr Glu Ala Xaa Asn Ser Lys Gly 
        915                 920                 925             


Pro Leu Ser Ser Leu Pro Ala Leu Pro Pro Ala Ser Asp Asp Gly Ala 
    930                 935                 940                 


Ala Pro Glu Asp Ala Asp Ser Pro Gln Ala Val Asp Val Ile Pro Val 
945                 950                 955                 960 


Asp Met Ile Ser Leu Ala Lys Gln Ile Ile Glu Ala Xaa Pro Glu Arg 
                965                 970                 975     


Ile Lys Arg Glu Asp Phe Val Gly Leu Pro Glu Ala Gly Ala Ser Met 
            980                 985                 990         


Arg Glu Arg Xaa Gly Ala Val Gly  Leu Ser Glu Xaa Met  Ser Trp Leu 
        995                 1000                 1005             


Ala Ser  Tyr Leu Glu Asn Val  Asp His Phe Pro Ser  Ser Xaa Pro 
    1010                 1015                 1020             


Pro Ser  Glu Leu Pro Phe Glu  Arg Gly Arg Leu Ala  Val Pro Ser 
    1025                 1030                 1035             


Ala Pro  Ser Trp Ala Glu Phe  Leu Ser Ala Ser Xaa  Ser Gly Lys 
    1040                 1045                 1050             


Met Glu  Ser Asp Phe Ala Leu  Leu Xaa Leu Ser Asp  His Glu Gln 
    1055                 1060                 1065             


Arg Glu  Leu Tyr Glu Ala Ala  Arg Val Ile Gln Xaa  Ala Phe Arg 
    1070                 1075                 1080             


Lys Tyr  Lys Gly Arg Arg Leu  Lys Glu Gln Gln Glu  Val Ala Ala 
    1085                 1090                 1095             


Ala Val  Ile Gln Arg Cys Tyr  Arg Lys Tyr Lys Gln  Leu Xaa Trp 
    1100                 1105                 1110             


Ile Ala  Leu Lys Phe Ala Leu  Tyr Lys Lys Met Xaa  Gln Ala Ala 
    1115                 1120                 1125             


Ile Leu  Ile Gln Ser Lys Phe  Arg Ser Tyr Tyr Glu  Gln Lys Arg 
    1130                 1135                 1140             


Phe Gln  Gln Ser Arg Arg Ala  Ala Val Leu Ile Gln  Gln His Tyr 
    1145                 1150                 1155             


Arg Ser  Tyr Arg Arg Arg Pro  Gly Pro Pro His Arg  Xaa Ser Ala 
    1160                 1165                 1170             


Xaa Leu  Pro Ala Arg Asn Lys  Leu Leu Ser His Gln  Glu Ala Gly 
    1175                 1180                 1185             


Pro Gly  Ser Pro Glu Asp His  Glu Ile Pro Ala Ala  Leu Pro Xaa 
    1190                 1195                 1200             


Gln Asp  Glu Gly Xaa Glu Ala  Glu Pro Gly Ala Gly  Arg Ala Ser 
    1205                 1210                 1215             


Pro Ala  Gly Xaa Gly His Met  Xaa Trp Pro Pro Pro  Phe Ser Pro 
    1220                 1225                 1230             


Pro Trp  Gly Arg Leu Val Gln  Ser 
    1235                 1240     


<210> 4880
<211> 1201
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1161)..(1161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<400> 4880
Met Gly Xaa Asp Ser Pro Ser Pro Arg Pro Leu Arg Pro Gly Val Xaa 
1               5                   10                  15      


Leu Pro Pro Gly Ala Leu Xaa Met Asn Xaa Lys Asp Xaa Xaa Glu Val 
            20                  25                  30          


Ala Glu Asn Ser His His Leu Lys Ile Phe Leu Pro Lys Lys Leu Leu 
        35                  40                  45              


Glu Cys Leu Pro Arg Cys Pro Leu Leu Pro Pro Glu Arg Leu Arg Trp 
    50                  55                  60                  


Asn Xaa Asn Glu Glu Ile Ala Ser Tyr Leu Ile Xaa Phe Glu Lys His 
65                  70                  75                  80  


Asp Glu Trp Leu Ser Cys Ala Pro Lys Xaa Arg Pro Gln Asn Gly Ser 
                85                  90                  95      


Ile Ile Leu Tyr Asn Arg Lys Lys Val Lys Tyr Arg Lys Asp Gly Tyr 
            100                 105                 110         


Leu Trp Lys Lys Arg Lys Asp Gly Lys Xaa Xaa Arg Glu Asp His Met 
        115                 120                 125             


Lys Leu Lys Val Gln Gly Met Glu Asn Pro Asp Ile Val Leu Val His 
    130                 135                 140                 


Tyr Leu Asn Val Pro Ala Leu Glu Asp Cys Gly Lys Gly Cys Ser Pro 
145                 150                 155                 160 


Ile Phe Cys Ser Ile Ser Ser Asp Arg Arg Glu Trp Leu Lys Trp Ser 
                165                 170                 175     


Arg Glu Glu Leu Leu Gly Gln Leu Lys Pro Met Phe His Gly Ile Lys 
            180                 185                 190         


Trp Ser Cys Gly Asn Gly Xaa Glu Glu Phe Ser Val Glu His Leu Val 
        195                 200                 205             


Gln Gln Ile Leu Asp Xaa His Pro Xaa Lys Pro Ala Pro Arg Xaa His 
    210                 215                 220                 


Ala Cys Leu Cys Ser Gly Gly Leu Gly Ser Gly Ser Leu Xaa His Lys 
225                 230                 235                 240 


Cys Ser Ser Xaa Lys His Arg Ile Ile Ser Pro Lys Val Glu Pro Arg 
                245                 250                 255     


Ala Leu Xaa Leu Xaa Ser Ile Pro His Ala His Pro Pro Glu Pro Pro 
            260                 265                 270         


Pro Leu Ile Ala Pro Leu Pro Pro Glu Leu Pro Lys Ala His Xaa Ser 
        275                 280                 285             


Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Phe Ala Glu Pro Leu 
    290                 295                 300                 


Glu Ile Arg Pro Ser Pro Pro Xaa Ser Arg Gly Gly Ser Ser Arg Gly 
305                 310                 315                 320 


Gly Xaa Ala Ile Leu Leu Leu Xaa Gly Leu Glu Gln Arg Ala Gly Gly 
                325                 330                 335     


Leu Xaa Pro Xaa Arg His Leu Ala Pro Gln Ala Asp Pro Arg Pro Ser 
            340                 345                 350         


Met Ser Leu Ala Val Val Val Gly Xaa Glu Pro Ser Ala Pro Pro Ala 
        355                 360                 365             


Pro Pro Ser Pro Ala Phe Asp Pro Asp Arg Phe Leu Asn Ser Pro Gln 
    370                 375                 380                 


Arg Gly Gln Xaa Tyr Gly Gly Gly Gln Gly Val Ser Pro Asp Phe Pro 
385                 390                 395                 400 


Glu Ala Glu Ala Ala His Xaa Pro Cys Ser Ala Leu Glu Pro Ala Ala 
                405                 410                 415     


Ala Leu Glu Pro Gln Ala Ala Ala Arg Gly Pro Pro Pro Gln Ser Val 
            420                 425                 430         


Ala Gly Gly Arg Arg Gly Asn Cys Phe Phe Ile Gln Asp Asp Asp Ser 
        435                 440                 445             


Gly Glu Glu Leu Lys Gly His Gly Ala Ala Pro Pro Ile Pro Ser Pro 
    450                 455                 460                 


Pro Pro Ser Pro Pro Pro Ser Pro Ala Pro Leu Glu Pro Ser Ser Arg 
465                 470                 475                 480 


Val Gly Arg Gly Glu Ala Leu Phe Gly Gly Pro Val Gly Ala Ser Glu 
                485                 490                 495     


Leu Glu Pro Phe Ser Leu Ser Ser Phe Pro Asp Leu Met Gly Glu Leu 
            500                 505                 510         


Ile Ser Asp Glu Ala Pro Ser Ile Pro Ala Pro Xaa Pro Gln Leu Ser 
        515                 520                 525             


Pro Ala Leu Ser Xaa Ile Xaa Asp Phe Ser Pro Glu Trp Ser Tyr Pro 
    530                 535                 540                 


Glu Gly Gly Val Lys Val Leu Ile Xaa Gly Pro Trp Xaa Glu Ala Ala 
545                 550                 555                 560 


Glu His Tyr Ser Cys Val Phe Asp His Ile Ala Val Pro Ala Ser Leu 
                565                 570                 575     


Val Gln Pro Gly Val Leu Arg Cys Tyr Cys Pro Ala His Glu Val Gly 
            580                 585                 590         


Leu Val Ser Leu Gln Val Ala Gly Arg Glu Gly Pro Leu Ser Ala Ser 
        595                 600                 605             


Val Leu Phe Glu Tyr Arg Ala Arg Arg Phe Leu Ser Leu Pro Ser Xaa 
    610                 615                 620                 


Gln Leu Asp Trp Leu Ser Leu Asp Asp Asn Gln Phe Arg Met Ser Ile 
625                 630                 635                 640 


Leu Glu Arg Leu Glu Gln Met Glu Lys Arg Met Ala Glu Ile Ala Ala 
                645                 650                 655     


Ala Gly Gln Val Pro Cys Gln Gly Pro Asp Ala Pro Pro Val Gln Asp 
            660                 665                 670         


Glu Gly Gln Gly Pro Gly Phe Glu Ala Arg Val Val Val Leu Val Glu 
        675                 680                 685             


Ser Met Ile Pro Arg Ser Xaa Trp Lys Gly Pro Glu Arg Leu Ala His 
    690                 695                 700                 


Gly Ser Pro Phe Arg Gly Met Ser Leu Leu His Leu Ala Ala Ala Gln 
705                 710                 715                 720 


Gly Tyr Ala Arg Leu Ile Glu Xaa Leu Ser Gln Trp Arg Ser Val Glu 
                725                 730                 735     


Xaa Gly Ser Leu Asp Leu Glu Gln Glu Val Asp Pro Leu Asn Val Asp 
            740                 745                 750         


His Phe Ser Cys Xaa Pro Leu Met Trp Ala Cys Ala Leu Gly His Leu 
        755                 760                 765             


Glu Ala Ala Val Leu Leu Phe Arg Trp Asn Arg Gln Ala Leu Ser Ile 
    770                 775                 780                 


Pro Asp Ser Leu Gly Arg Leu Pro Leu Ser Val Ala His Ser Arg Gly 
785                 790                 795                 800 


His Val Arg Leu Ala Arg Cys Leu Glu Glu Leu Gln Arg Gln Glu Pro 
                805                 810                 815     


Ser Val Glu Pro Pro Phe Ala Leu Ser Pro Pro Ser Ser Ser Pro Asp 
            820                 825                 830         


Xaa Gly Leu Ser Ser Val Ser Ser Pro Ser Glu Leu Ser Asp Gly Xaa 
        835                 840                 845             


Phe Ser Val Xaa Ser Ala Tyr Ser Ser Ala Pro Asp Gly Ser Pro Pro 
    850                 855                 860                 


Pro Ala Pro Leu Pro Ala Ser Glu Met Xaa Met Glu Asp Met Ala Pro 
865                 870                 875                 880 


Gly Gln Leu Ser Ser Gly Val Pro Glu Ala Pro Leu Leu Leu Met Asp 
                885                 890                 895     


Tyr Glu Ala Xaa Asn Ser Lys Gly Pro Leu Ser Ser Leu Pro Ala Leu 
            900                 905                 910         


Pro Pro Ala Ser Asp Asp Gly Ala Ala Pro Glu Asp Ala Asp Ser Pro 
        915                 920                 925             


Gln Ala Val Asp Val Ile Pro Val Asp Met Ile Ser Leu Ala Lys Gln 
    930                 935                 940                 


Ile Ile Glu Ala Xaa Pro Glu Arg Ile Lys Arg Glu Asp Phe Val Gly 
945                 950                 955                 960 


Leu Pro Glu Ala Gly Ala Ser Met Arg Glu Arg Xaa Gly Ala Val Gly 
                965                 970                 975     


Leu Ser Glu Xaa Met Ser Trp Leu Ala Ser Tyr Leu Glu Asn Val Asp 
            980                 985                 990         


His Phe Pro Ser Ser Xaa Pro Pro  Ser Glu Leu Pro Phe  Glu Arg Gly 
        995                 1000                 1005             


Arg Leu  Ala Val Pro Ser Ala  Pro Ser Trp Ala Glu  Phe Leu Ser 
    1010                 1015                 1020             


Ala Ser  Xaa Ser Gly Lys Met  Glu Ser Asp Phe Ala  Leu Leu Xaa 
    1025                 1030                 1035             


Leu Ser  Asp His Glu Gln Arg  Glu Leu Tyr Glu Ala  Ala Arg Val 
    1040                 1045                 1050             


Ile Gln  Xaa Ala Phe Arg Lys  Tyr Lys Gly Arg Arg  Leu Lys Glu 
    1055                 1060                 1065             


Gln Gln  Glu Val Ala Ala Ala  Val Ile Gln Arg Cys  Tyr Arg Lys 
    1070                 1075                 1080             


Tyr Lys  Gln Leu Xaa Trp Ile  Ala Leu Lys Phe Ala  Leu Tyr Lys 
    1085                 1090                 1095             


Lys Met  Xaa Gln Ala Ala Ile  Leu Ile Gln Ser Lys  Phe Arg Ser 
    1100                 1105                 1110             


Tyr Tyr  Glu Gln Lys Arg Phe  Gln Gln Ser Arg Arg  Ala Ala Val 
    1115                 1120                 1125             


Leu Ile  Gln Gln His Tyr Arg  Ser Tyr Arg Arg Arg  Pro Gly Pro 
    1130                 1135                 1140             


Pro His  Arg Xaa Ser Ala Xaa  Leu Pro Ala Arg Asn  Lys Gly Ser 
    1145                 1150                 1155             


Phe Leu  Xaa Lys Lys Gln Asp  Gln Ala Ala Arg Lys  Ile Met Arg 
    1160                 1165                 1170             


Phe Leu  Arg Arg Cys Arg His  Arg Met Arg Glu Leu  Lys Gln Asn 
    1175                 1180                 1185             


Gln Glu  Leu Glu Gly Leu Pro  Gln Pro Gly Leu Ala  Xaa 
    1190                 1195                 1200     


<210> 4881
<211> 1202
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<400> 4881
Met Asn Xaa Lys Asp Xaa Xaa Glu Val Ala Glu Asn Ser His His Leu 
1               5                   10                  15      


Lys Ile Phe Leu Pro Lys Lys Leu Leu Glu Cys Leu Pro Arg Cys Pro 
            20                  25                  30          


Leu Leu Pro Pro Glu Arg Leu Arg Trp Asn Xaa Asn Glu Glu Ile Ala 
        35                  40                  45              


Ser Tyr Leu Ile Xaa Phe Glu Lys His Asp Glu Trp Leu Ser Cys Ala 
    50                  55                  60                  


Pro Lys Xaa Arg Pro Gln Asn Gly Ser Ile Ile Leu Tyr Asn Arg Lys 
65                  70                  75                  80  


Lys Val Lys Tyr Arg Lys Asp Gly Tyr Leu Trp Lys Lys Arg Lys Asp 
                85                  90                  95      


Gly Lys Xaa Xaa Arg Glu Asp His Met Lys Leu Lys Val Gln Gly Met 
            100                 105                 110         


Glu Cys Leu Tyr Gly Cys Tyr Val His Ser Ser Ile Val Pro Xaa Phe 
        115                 120                 125             


His Arg Arg Cys Tyr Trp Leu Leu Gln Asn Pro Asp Ile Val Leu Val 
    130                 135                 140                 


His Tyr Leu Asn Val Pro Ala Leu Glu Asp Cys Gly Lys Gly Cys Ser 
145                 150                 155                 160 


Pro Ile Phe Cys Ser Ile Ser Ser Asp Arg Arg Glu Trp Leu Lys Trp 
                165                 170                 175     


Ser Arg Glu Glu Leu Leu Gly Gln Leu Lys Pro Met Phe His Gly Ile 
            180                 185                 190         


Lys Trp Ser Cys Gly Asn Gly Xaa Glu Glu Phe Ser Val Glu His Leu 
        195                 200                 205             


Val Gln Gln Ile Leu Asp Xaa His Pro Xaa Lys Pro Ala Pro Arg Xaa 
    210                 215                 220                 


His Ala Cys Leu Cys Ser Gly Gly Leu Gly Ser Gly Ser Leu Xaa His 
225                 230                 235                 240 


Lys Cys Ser Ser Xaa Lys His Arg Ile Ile Ser Pro Lys Val Glu Pro 
                245                 250                 255     


Arg Ala Leu Xaa Leu Xaa Ser Ile Pro His Ala His Pro Pro Glu Pro 
            260                 265                 270         


Pro Pro Leu Ile Ala Pro Leu Pro Pro Glu Leu Pro Lys Ala His Xaa 
        275                 280                 285             


Ser Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Phe Ala Glu Pro 
    290                 295                 300                 


Leu Glu Ile Arg Pro Ser Pro Pro Xaa Ser Arg Gly Gly Ser Ser Arg 
305                 310                 315                 320 


Gly Gly Xaa Ala Ile Leu Leu Leu Xaa Gly Leu Glu Gln Arg Ala Gly 
                325                 330                 335     


Gly Leu Xaa Pro Xaa Arg His Leu Ala Pro Gln Ala Asp Pro Arg Pro 
            340                 345                 350         


Ser Met Ser Leu Ala Val Val Val Gly Xaa Glu Pro Ser Ala Pro Pro 
        355                 360                 365             


Ala Pro Pro Ser Pro Ala Phe Asp Pro Asp Arg Phe Leu Asn Ser Pro 
    370                 375                 380                 


Gln Arg Gly Gln Xaa Tyr Gly Gly Gly Gln Gly Val Ser Pro Asp Phe 
385                 390                 395                 400 


Pro Glu Ala Glu Ala Ala His Xaa Pro Cys Ser Ala Leu Glu Pro Ala 
                405                 410                 415     


Ala Ala Leu Glu Pro Gln Ala Ala Ala Arg Gly Pro Pro Pro Gln Ser 
            420                 425                 430         


Val Ala Gly Gly Arg Arg Gly Asn Cys Phe Phe Ile Gln Asp Asp Asp 
        435                 440                 445             


Ser Gly Glu Glu Leu Lys Gly His Gly Ala Ala Pro Pro Ile Pro Ser 
    450                 455                 460                 


Pro Pro Pro Ser Pro Pro Pro Ser Pro Ala Pro Leu Glu Pro Ser Ser 
465                 470                 475                 480 


Arg Val Gly Arg Gly Glu Ala Leu Phe Gly Gly Pro Val Gly Ala Ser 
                485                 490                 495     


Glu Leu Glu Pro Phe Ser Leu Ser Ser Phe Pro Asp Leu Met Gly Glu 
            500                 505                 510         


Leu Ile Ser Asp Glu Ala Pro Ser Ile Pro Ala Pro Xaa Pro Gln Leu 
        515                 520                 525             


Ser Pro Ala Leu Ser Xaa Ile Xaa Asp Phe Ser Pro Glu Trp Ser Tyr 
    530                 535                 540                 


Pro Glu Gly Gly Val Lys Val Leu Ile Xaa Gly Pro Trp Xaa Glu Ala 
545                 550                 555                 560 


Ala Glu His Tyr Ser Cys Val Phe Asp His Ile Ala Val Pro Ala Ser 
                565                 570                 575     


Leu Val Gln Pro Gly Val Leu Arg Cys Tyr Cys Pro Ala His Glu Val 
            580                 585                 590         


Gly Leu Val Ser Leu Gln Val Ala Gly Arg Glu Gly Pro Leu Ser Ala 
        595                 600                 605             


Ser Val Leu Phe Glu Tyr Arg Ala Arg Arg Phe Leu Ser Leu Pro Ser 
    610                 615                 620                 


Xaa Gln Leu Asp Trp Leu Ser Leu Asp Asp Asn Gln Phe Arg Met Ser 
625                 630                 635                 640 


Ile Leu Glu Arg Leu Glu Gln Met Glu Lys Arg Met Ala Glu Ile Ala 
                645                 650                 655     


Ala Ala Gly Gln Val Pro Cys Gln Gly Pro Asp Ala Pro Pro Val Gln 
            660                 665                 670         


Asp Glu Gly Gln Gly Pro Gly Phe Glu Ala Arg Val Val Val Leu Val 
        675                 680                 685             


Glu Ser Met Ile Pro Arg Ser Xaa Trp Lys Gly Pro Glu Arg Leu Ala 
    690                 695                 700                 


His Gly Ser Pro Phe Arg Gly Met Ser Leu Leu His Leu Ala Ala Ala 
705                 710                 715                 720 


Gln Gly Tyr Ala Arg Leu Ile Glu Xaa Leu Ser Gln Trp Arg Ser Val 
                725                 730                 735     


Glu Xaa Gly Ser Leu Asp Leu Glu Gln Glu Val Asp Pro Leu Asn Val 
            740                 745                 750         


Asp His Phe Ser Cys Xaa Pro Leu Met Trp Ala Cys Ala Leu Gly His 
        755                 760                 765             


Leu Glu Ala Ala Val Leu Leu Phe Arg Trp Asn Arg Gln Ala Leu Ser 
    770                 775                 780                 


Ile Pro Asp Ser Leu Gly Arg Leu Pro Leu Ser Val Ala His Ser Arg 
785                 790                 795                 800 


Gly His Val Arg Leu Ala Arg Cys Leu Glu Glu Leu Gln Arg Gln Glu 
                805                 810                 815     


Pro Ser Val Glu Pro Pro Phe Ala Leu Ser Pro Pro Ser Ser Ser Pro 
            820                 825                 830         


Asp Xaa Gly Leu Ser Ser Val Ser Ser Pro Ser Glu Leu Ser Asp Gly 
        835                 840                 845             


Xaa Phe Ser Val Xaa Ser Ala Tyr Ser Ser Ala Pro Asp Gly Ser Pro 
    850                 855                 860                 


Pro Pro Ala Pro Leu Pro Ala Ser Glu Met Xaa Met Glu Asp Met Ala 
865                 870                 875                 880 


Pro Gly Gln Leu Ser Ser Gly Val Pro Glu Ala Pro Leu Leu Leu Met 
                885                 890                 895     


Asp Tyr Glu Ala Xaa Asn Ser Lys Gly Pro Leu Ser Ser Leu Pro Ala 
            900                 905                 910         


Leu Pro Pro Ala Ser Asp Asp Gly Ala Ala Pro Glu Asp Ala Asp Ser 
        915                 920                 925             


Pro Gln Ala Val Asp Val Ile Pro Val Asp Met Ile Ser Leu Ala Lys 
    930                 935                 940                 


Gln Ile Ile Glu Ala Xaa Pro Glu Arg Ile Lys Arg Glu Asp Phe Val 
945                 950                 955                 960 


Gly Leu Pro Glu Ala Gly Ala Ser Met Arg Glu Arg Xaa Gly Ala Val 
                965                 970                 975     


Gly Leu Ser Glu Xaa Met Ser Trp Leu Ala Ser Tyr Leu Glu Asn Val 
            980                 985                 990         


Asp His Phe Pro Ser Ser Xaa Pro  Pro Ser Glu Leu Pro  Phe Glu Arg 
        995                 1000                 1005             


Gly Arg  Leu Ala Val Pro Ser  Ala Pro Ser Trp Ala  Glu Phe Leu 
    1010                 1015                 1020             


Ser Ala  Ser Xaa Ser Gly Lys  Met Glu Ser Asp Phe  Ala Leu Leu 
    1025                 1030                 1035             


Xaa Leu  Ser Asp His Glu Gln  Arg Glu Leu Tyr Glu  Ala Ala Arg 
    1040                 1045                 1050             


Val Ile  Gln Xaa Ala Phe Arg  Lys Tyr Lys Gly Arg  Arg Leu Lys 
    1055                 1060                 1065             


Glu Gln  Gln Glu Val Ala Ala  Ala Val Ile Gln Arg  Cys Tyr Arg 
    1070                 1075                 1080             


Lys Tyr  Lys Gln Leu Xaa Trp  Ile Ala Leu Lys Phe  Ala Leu Tyr 
    1085                 1090                 1095             


Lys Lys  Met Xaa Gln Ala Ala  Ile Leu Ile Gln Ser  Lys Phe Arg 
    1100                 1105                 1110             


Ser Tyr  Tyr Glu Gln Lys Arg  Phe Gln Gln Ser Arg  Arg Ala Ala 
    1115                 1120                 1125             


Val Leu  Ile Gln Gln His Tyr  Arg Ser Tyr Arg Arg  Arg Pro Gly 
    1130                 1135                 1140             


Pro Pro  His Arg Xaa Ser Ala  Xaa Leu Pro Ala Arg  Asn Lys Gly 
    1145                 1150                 1155             


Ser Phe  Leu Xaa Lys Lys Gln  Asp Gln Ala Ala Arg  Lys Ile Met 
    1160                 1165                 1170             


Arg Phe  Leu Arg Arg Cys Arg  His Arg Met Arg Glu  Leu Lys Gln 
    1175                 1180                 1185             


Asn Gln  Glu Leu Glu Gly Leu  Pro Gln Pro Gly Leu  Ala Xaa 
    1190                 1195                 1200         


<210> 4882
<211> 161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 4882
Met Asn Xaa Lys Asp Xaa Xaa Glu Val Ala Glu Asn Ser His His Leu 
1               5                   10                  15      


Lys Ile Phe Leu Pro Lys Lys Leu Leu Glu Cys Leu Pro Arg Cys Pro 
            20                  25                  30          


Leu Leu Pro Pro Glu Arg Leu Arg Trp Asn Xaa Asn Glu Glu Ile Ala 
        35                  40                  45              


Ser Tyr Leu Ile Xaa Phe Glu Lys His Asp Glu Trp Leu Ser Cys Ala 
    50                  55                  60                  


Pro Lys Xaa Arg Pro Gln Asn Gly Ser Ile Ile Leu Tyr Asn Arg Lys 
65                  70                  75                  80  


Lys Val Lys Tyr Arg Lys Asp Gly Tyr Leu Trp Lys Lys Arg Lys Asp 
                85                  90                  95      


Gly Lys Xaa Xaa Arg Glu Asp His Met Lys Leu Lys Val Gln Gly Met 
            100                 105                 110         


Glu Gly Leu Asn Arg Gly Arg Val Gly Glu Gln Xaa Ser Pro Pro Pro 
        115                 120                 125             


Xaa Pro Ala Cys Leu Leu Ala Val Ser Leu Trp Leu Leu Arg Ser Leu 
    130                 135                 140                 


Phe His Arg Pro His Ile Pro Ser Ala Leu Leu Leu Ala Ala Pro Glu 
145                 150                 155                 160 


Pro 
    


<210> 4883
<211> 1207
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1107)..(1107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<400> 4883
Met Asn Xaa Lys Asp Xaa Xaa Glu Val Ala Glu Asn Ser His His Leu 
1               5                   10                  15      


Lys Ile Phe Leu Pro Lys Lys Leu Leu Glu Cys Leu Pro Arg Cys Pro 
            20                  25                  30          


Leu Leu Pro Pro Glu Arg Leu Arg Trp Asn Xaa Asn Glu Glu Ile Ala 
        35                  40                  45              


Ser Tyr Leu Ile Xaa Phe Glu Lys His Asp Glu Trp Leu Ser Cys Ala 
    50                  55                  60                  


Pro Lys Xaa Arg Pro Gln Asn Gly Ser Ile Ile Leu Tyr Asn Arg Lys 
65                  70                  75                  80  


Lys Val Lys Tyr Arg Lys Asp Gly Tyr Leu Trp Lys Lys Arg Lys Asp 
                85                  90                  95      


Gly Lys Xaa Xaa Arg Glu Asp His Met Lys Leu Lys Val Gln Gly Met 
            100                 105                 110         


Glu Pro Val Ser Trp Gln Cys Leu Tyr Gly Cys Tyr Val His Ser Ser 
        115                 120                 125             


Ile Val Pro Xaa Phe His Arg Arg Cys Tyr Trp Leu Leu Gln Asn Pro 
    130                 135                 140                 


Asp Ile Val Leu Val His Tyr Leu Asn Val Pro Ala Leu Glu Asp Cys 
145                 150                 155                 160 


Gly Lys Gly Cys Ser Pro Ile Phe Cys Ser Ile Ser Ser Asp Arg Arg 
                165                 170                 175     


Glu Trp Leu Lys Trp Ser Arg Glu Glu Leu Leu Gly Gln Leu Lys Pro 
            180                 185                 190         


Met Phe His Gly Ile Lys Trp Ser Cys Gly Asn Gly Xaa Glu Glu Phe 
        195                 200                 205             


Ser Val Glu His Leu Val Gln Gln Ile Leu Asp Xaa His Pro Xaa Lys 
    210                 215                 220                 


Pro Ala Pro Arg Xaa His Ala Cys Leu Cys Ser Gly Gly Leu Gly Ser 
225                 230                 235                 240 


Gly Ser Leu Xaa His Lys Cys Ser Ser Xaa Lys His Arg Ile Ile Ser 
                245                 250                 255     


Pro Lys Val Glu Pro Arg Ala Leu Xaa Leu Xaa Ser Ile Pro His Ala 
            260                 265                 270         


His Pro Pro Glu Pro Pro Pro Leu Ile Ala Pro Leu Pro Pro Glu Leu 
        275                 280                 285             


Pro Lys Ala His Xaa Ser Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser 
    290                 295                 300                 


Gly Phe Ala Glu Pro Leu Glu Ile Arg Pro Ser Pro Pro Xaa Ser Arg 
305                 310                 315                 320 


Gly Gly Ser Ser Arg Gly Gly Xaa Ala Ile Leu Leu Leu Xaa Gly Leu 
                325                 330                 335     


Glu Gln Arg Ala Gly Gly Leu Xaa Pro Xaa Arg His Leu Ala Pro Gln 
            340                 345                 350         


Ala Asp Pro Arg Pro Ser Met Ser Leu Ala Val Val Val Gly Xaa Glu 
        355                 360                 365             


Pro Ser Ala Pro Pro Ala Pro Pro Ser Pro Ala Phe Asp Pro Asp Arg 
    370                 375                 380                 


Phe Leu Asn Ser Pro Gln Arg Gly Gln Xaa Tyr Gly Gly Gly Gln Gly 
385                 390                 395                 400 


Val Ser Pro Asp Phe Pro Glu Ala Glu Ala Ala His Xaa Pro Cys Ser 
                405                 410                 415     


Ala Leu Glu Pro Ala Ala Ala Leu Glu Pro Gln Ala Ala Ala Arg Gly 
            420                 425                 430         


Pro Pro Pro Gln Ser Val Ala Gly Gly Arg Arg Gly Asn Cys Phe Phe 
        435                 440                 445             


Ile Gln Asp Asp Asp Ser Gly Glu Glu Leu Lys Gly His Gly Ala Ala 
    450                 455                 460                 


Pro Pro Ile Pro Ser Pro Pro Pro Ser Pro Pro Pro Ser Pro Ala Pro 
465                 470                 475                 480 


Leu Glu Pro Ser Ser Arg Val Gly Arg Gly Glu Ala Leu Phe Gly Gly 
                485                 490                 495     


Pro Val Gly Ala Ser Glu Leu Glu Pro Phe Ser Leu Ser Ser Phe Pro 
            500                 505                 510         


Asp Leu Met Gly Glu Leu Ile Ser Asp Glu Ala Pro Ser Ile Pro Ala 
        515                 520                 525             


Pro Xaa Pro Gln Leu Ser Pro Ala Leu Ser Xaa Ile Xaa Asp Phe Ser 
    530                 535                 540                 


Pro Glu Trp Ser Tyr Pro Glu Gly Gly Val Lys Val Leu Ile Xaa Gly 
545                 550                 555                 560 


Pro Trp Xaa Glu Ala Ala Glu His Tyr Ser Cys Val Phe Asp His Ile 
                565                 570                 575     


Ala Val Pro Ala Ser Leu Val Gln Pro Gly Val Leu Arg Cys Tyr Cys 
            580                 585                 590         


Pro Ala His Glu Val Gly Leu Val Ser Leu Gln Val Ala Gly Arg Glu 
        595                 600                 605             


Gly Pro Leu Ser Ala Ser Val Leu Phe Glu Tyr Arg Ala Arg Arg Phe 
    610                 615                 620                 


Leu Ser Leu Pro Ser Xaa Gln Leu Asp Trp Leu Ser Leu Asp Asp Asn 
625                 630                 635                 640 


Gln Phe Arg Met Ser Ile Leu Glu Arg Leu Glu Gln Met Glu Lys Arg 
                645                 650                 655     


Met Ala Glu Ile Ala Ala Ala Gly Gln Val Pro Cys Gln Gly Pro Asp 
            660                 665                 670         


Ala Pro Pro Val Gln Asp Glu Gly Gln Gly Pro Gly Phe Glu Ala Arg 
        675                 680                 685             


Val Val Val Leu Val Glu Ser Met Ile Pro Arg Ser Xaa Trp Lys Gly 
    690                 695                 700                 


Pro Glu Arg Leu Ala His Gly Ser Pro Phe Arg Gly Met Ser Leu Leu 
705                 710                 715                 720 


His Leu Ala Ala Ala Gln Gly Tyr Ala Arg Leu Ile Glu Xaa Leu Ser 
                725                 730                 735     


Gln Trp Arg Ser Val Glu Xaa Gly Ser Leu Asp Leu Glu Gln Glu Val 
            740                 745                 750         


Asp Pro Leu Asn Val Asp His Phe Ser Cys Xaa Pro Leu Met Trp Ala 
        755                 760                 765             


Cys Ala Leu Gly His Leu Glu Ala Ala Val Leu Leu Phe Arg Trp Asn 
    770                 775                 780                 


Arg Gln Ala Leu Ser Ile Pro Asp Ser Leu Gly Arg Leu Pro Leu Ser 
785                 790                 795                 800 


Val Ala His Ser Arg Gly His Val Arg Leu Ala Arg Cys Leu Glu Glu 
                805                 810                 815     


Leu Gln Arg Gln Glu Pro Ser Val Glu Pro Pro Phe Ala Leu Ser Pro 
            820                 825                 830         


Pro Ser Ser Ser Pro Asp Xaa Gly Leu Ser Ser Val Ser Ser Pro Ser 
        835                 840                 845             


Glu Leu Ser Asp Gly Xaa Phe Ser Val Xaa Ser Ala Tyr Ser Ser Ala 
    850                 855                 860                 


Pro Asp Gly Ser Pro Pro Pro Ala Pro Leu Pro Ala Ser Glu Met Xaa 
865                 870                 875                 880 


Met Glu Asp Met Ala Pro Gly Gln Leu Ser Ser Gly Val Pro Glu Ala 
                885                 890                 895     


Pro Leu Leu Leu Met Asp Tyr Glu Ala Xaa Asn Ser Lys Gly Pro Leu 
            900                 905                 910         


Ser Ser Leu Pro Ala Leu Pro Pro Ala Ser Asp Asp Gly Ala Ala Pro 
        915                 920                 925             


Glu Asp Ala Asp Ser Pro Gln Ala Val Asp Val Ile Pro Val Asp Met 
    930                 935                 940                 


Ile Ser Leu Ala Lys Gln Ile Ile Glu Ala Xaa Pro Glu Arg Ile Lys 
945                 950                 955                 960 


Arg Glu Asp Phe Val Gly Leu Pro Glu Ala Gly Ala Ser Met Arg Glu 
                965                 970                 975     


Arg Xaa Gly Ala Val Gly Leu Ser Glu Xaa Met Ser Trp Leu Ala Ser 
            980                 985                 990         


Tyr Leu Glu Asn Val Asp His Phe  Pro Ser Ser Xaa Pro  Pro Ser Glu 
        995                 1000                 1005             


Leu Pro  Phe Glu Arg Gly Arg  Leu Ala Val Pro Ser  Ala Pro Ser 
    1010                 1015                 1020             


Trp Ala  Glu Phe Leu Ser Ala  Ser Xaa Ser Gly Lys  Met Glu Ser 
    1025                 1030                 1035             


Asp Phe  Ala Leu Leu Xaa Leu  Ser Asp His Glu Gln  Arg Glu Leu 
    1040                 1045                 1050             


Tyr Glu  Ala Ala Arg Val Ile  Gln Xaa Ala Phe Arg  Lys Tyr Lys 
    1055                 1060                 1065             


Gly Arg  Arg Leu Lys Glu Gln  Gln Glu Val Ala Ala  Ala Val Ile 
    1070                 1075                 1080             


Gln Arg  Cys Tyr Arg Lys Tyr  Lys Gln Leu Xaa Trp  Ile Ala Leu 
    1085                 1090                 1095             


Lys Phe  Ala Leu Tyr Lys Lys  Met Xaa Gln Ala Ala  Ile Leu Ile 
    1100                 1105                 1110             


Gln Ser  Lys Phe Arg Ser Tyr  Tyr Glu Gln Lys Arg  Phe Gln Gln 
    1115                 1120                 1125             


Ser Arg  Arg Ala Ala Val Leu  Ile Gln Gln His Tyr  Arg Ser Tyr 
    1130                 1135                 1140             


Arg Arg  Arg Pro Gly Pro Pro  His Arg Xaa Ser Ala  Xaa Leu Pro 
    1145                 1150                 1155             


Ala Arg  Asn Lys Gly Ser Phe  Leu Xaa Lys Lys Gln  Asp Gln Ala 
    1160                 1165                 1170             


Ala Arg  Lys Ile Met Arg Phe  Leu Arg Arg Cys Arg  His Arg Met 
    1175                 1180                 1185             


Arg Glu  Leu Lys Gln Asn Gln  Glu Leu Glu Gly Leu  Pro Gln Pro 
    1190                 1195                 1200             


Gly Leu  Ala Xaa 
    1205         


<210> 4884
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4884
Met Pro Val Gln Leu Ser Glu His Pro Glu Trp Asn Glu Ser Met 
1               5                   10                  15  


<210> 4885
<211> 38
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<400> 4885
Met Pro Val Gln Leu Ser Glu His Pro Glu Trp Asn Glu Ser Met His 
1               5                   10                  15      


Ser Leu Arg Ile Ser Val Gly Gly Leu Pro Val Leu Ala Ser Met Xaa 
            20                  25                  30          


Lys Ala Ala Asp Pro Arg 
        35              


<210> 4886
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<400> 4886
Met Pro Val Gln Leu Ser Glu His Pro Glu Trp Asn Glu Ser Met His 
1               5                   10                  15      


Ser Leu Arg Ile Ser Val Gly Gly Leu Pro Val Leu Ala Ser Met Xaa 
            20                  25                  30          


Lys Ala Ala Asp Pro Arg Phe Arg Pro Arg Trp Lys Asp Xaa Gly Trp 
        35                  40                  45              


Asp Ser Val Ser Asn Arg Ser Tyr Arg Arg Pro Gly His Arg Val Lys 
    50                  55                  60                  


Gly Pro Arg Gly Lys His Leu Val Gln Leu Pro Glu Lys Gly Leu Pro 
65                  70                  75                  80  


Asp Pro Val Arg Gln Trp Gly Gln Gly Gly Arg Gly Met Gly Gln Arg 
                85                  90                  95      


Pro Trp Gly Pro Gly Val Pro Pro Gly Gly Glu Gly Glu Arg His Gly 
            100                 105                 110         


Ala Ile Arg Pro Asp Cys 
        115             


<210> 4887
<211> 61
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<400> 4887
Met Pro Val Gln Leu Ser Glu His Pro Glu Trp Asn Glu Ser Met His 
1               5                   10                  15      


Ser Leu Arg Ile Ser Val Gly Gly Leu Pro Val Leu Ala Ser Met Xaa 
            20                  25                  30          


Lys Ala Ala Asp Pro Arg Phe Arg Pro Arg Trp Lys Val Ile Leu Xaa 
        35                  40                  45              


Phe Phe Val Gly Ala Ala Ile Leu Trp Leu Leu Cys Ser 
    50                  55                  60      


<210> 4888
<211> 65
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<400> 4888
Met Pro Val Gln Leu Ser Glu His Pro Glu Trp Asn Glu Ser Met His 
1               5                   10                  15      


Ser Leu Arg Ile Ser Val Gly Gly Leu Pro Val Leu Ala Ser Met Xaa 
            20                  25                  30          


Lys Ala Ala Asp Pro Arg Phe Arg Pro Arg Trp Lys Val Ile Leu Xaa 
        35                  40                  45              


Phe Phe Val Gly Ala Ala Ile Leu Trp Leu Leu Cys Ser His Arg Pro 
    50                  55                  60                  


Ala 
65  


<210> 4889
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<400> 4889
Met Pro Val Gln Leu Ser Glu His Pro Glu Trp Asn Glu Ser Met His 
1               5                   10                  15      


Ser Leu Arg Ile Ser Val Gly Gly Leu Pro Val Leu Ala Ser Met Xaa 
            20                  25                  30          


Lys Ala Ala Asp Pro Arg Phe Arg Pro Arg Trp Lys Val Ile Leu Xaa 
        35                  40                  45              


Phe Phe Val Gly Ala Ala Ile Leu Trp Leu Leu Cys Ser His Arg Pro 
    50                  55                  60                  


Ala Pro Gly Arg Pro Pro Xaa His Asn Ala His Asn 
65                  70                  75      


<210> 4890
<211> 401
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<400> 4890
Met Pro Val Gln Leu Ser Glu His Pro Glu Trp Asn Glu Ser Met His 
1               5                   10                  15      


Ser Leu Arg Ile Ser Val Gly Gly Leu Pro Val Leu Ala Ser Met Xaa 
            20                  25                  30          


Lys Ala Ala Asp Pro Arg Phe Arg Pro Arg Trp Lys Val Ile Leu Xaa 
        35                  40                  45              


Phe Phe Val Gly Ala Ala Ile Leu Trp Leu Leu Cys Ser His Arg Pro 
    50                  55                  60                  


Ala Pro Gly Arg Pro Pro Xaa His Asn Ala His Asn Trp Arg Leu Gly 
65                  70                  75                  80  


Gln Ala Pro Ala Asn Trp Tyr Asn Asp Xaa Tyr Pro Leu Ser Pro Pro 
                85                  90                  95      


Gln Arg Xaa Pro Ala Gly Ile Arg Tyr Arg Ile Ala Val Ile Ala Asp 
            100                 105                 110         


Leu Asp Xaa Glu Ser Arg Ala Gln Glu Glu Asn Xaa Trp Phe Ser Tyr 
        115                 120                 125             


Leu Lys Lys Gly Tyr Leu Xaa Leu Ser Asp Ser Gly Asp Lys Val Ala 
    130                 135                 140                 


Val Glu Trp Asp Lys Asp His Gly Val Leu Glu Ser His Leu Ala Glu 
145                 150                 155                 160 


Lys Gly Arg Gly Met Glu Leu Ser Asp Leu Ile Val Phe Asn Gly Lys 
                165                 170                 175     


Leu Tyr Ser Val Asp Asp Arg Xaa Gly Val Val Tyr Gln Ile Glu Gly 
            180                 185                 190         


Ser Lys Ala Val Pro Trp Val Ile Leu Ser Asp Gly Asp Gly Xaa Val 
        195                 200                 205             


Glu Lys Gly Phe Lys Ala Glu Trp Leu Ala Val Lys Asp Glu Arg Leu 
    210                 215                 220                 


Tyr Val Gly Gly Leu Gly Lys Glu Trp Xaa Xaa Xaa Xaa Gly Asp Val 
225                 230                 235                 240 


Val Asn Glu Asn Pro Glu Trp Val Lys Val Val Gly Tyr Lys Gly Ser 
                245                 250                 255     


Val Asp His Glu Asn Trp Val Ser Asn Tyr Asn Ala Leu Arg Ala Ala 
            260                 265                 270         


Ala Gly Ile Gln Pro Pro Gly Tyr Leu Ile His Glu Ser Ala Cys Trp 
        275                 280                 285             


Ser Asp Xaa Leu Gln Arg Trp Phe Phe Leu Pro Arg Arg Ala Ser Gln 
    290                 295                 300                 


Glu Arg Tyr Ser Glu Lys Asp Asp Glu Arg Lys Gly Ala Asn Leu Leu 
305                 310                 315                 320 


Leu Ser Ala Ser Pro Asp Phe Gly Asp Ile Ala Val Ser His Val Gly 
                325                 330                 335     


Ala Val Val Pro Xaa His Gly Phe Ser Ser Phe Lys Phe Ile Pro Asn 
            340                 345                 350         


Xaa Asp Asp Gln Ile Ile Val Ala Leu Lys Ser Glu Glu Asp Ser Gly 
        355                 360                 365             


Arg Val Ala Ser Tyr Ile Met Ala Phe Xaa Leu Asp Gly Arg Phe Leu 
    370                 375                 380                 


Leu Pro Glu Xaa Lys Ile Gly Ser Val Lys Tyr Glu Gly Ile Glu Phe 
385                 390                 395                 400 


Ile 
    


<210> 4891
<211> 264
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<400> 4891
Met Pro Val Gln Leu Ser Glu His Pro Glu Trp Asn Glu Ser Met His 
1               5                   10                  15      


Ser Leu Arg Ile Ser Val Gly Gly Leu Pro Val Leu Ala Ser Met Xaa 
            20                  25                  30          


Lys Ala Ala Asp Pro Arg Phe Arg Pro Arg Trp Lys Val Ile Leu Xaa 
        35                  40                  45              


Phe Phe Val Gly Ala Ala Ile Leu Trp Leu Leu Cys Ser His Arg Pro 
    50                  55                  60                  


Ala Pro Gly Arg Pro Pro Xaa His Asn Ala His Asn Trp Arg Leu Gly 
65                  70                  75                  80  


Gln Ala Pro Ala Asn Trp Tyr Asn Asp Xaa Tyr Pro Leu Ser Pro Pro 
                85                  90                  95      


Gln Arg Xaa Pro Ala Gly Ile Arg Tyr Arg Ile Ala Val Ile Ala Asp 
            100                 105                 110         


Leu Asp Xaa Glu Ser Arg Ala Gln Glu Glu Asn Xaa Trp Phe Ser Tyr 
        115                 120                 125             


Leu Lys Lys Gly Tyr Leu Xaa Leu Ser Asp Ser Gly Asp Lys Val Ala 
    130                 135                 140                 


Val Glu Trp Asp Lys Asp His Gly Val Leu Glu Ser His Leu Ala Glu 
145                 150                 155                 160 


Lys Gly Arg Gly Met Glu Leu Ser Asp Leu Ile Val Phe Asn Gly Lys 
                165                 170                 175     


Leu Tyr Ser Val Asp Asp Arg Xaa Gly Val Val Tyr Gln Ile Glu Gly 
            180                 185                 190         


Ser Lys Ala Val Pro Trp Val Ile Leu Ser Asp Gly Asp Gly Xaa Val 
        195                 200                 205             


Glu Lys Gly Asn Trp Xaa Leu Ser Ser Ala Gly Asp Cys Lys Glu Ala 
    210                 215                 220                 


Val Ala Ala Gly Glu Ala Ser Leu Xaa Cys Arg Arg Ser Trp Pro Met 
225                 230                 235                 240 


Asp Xaa Lys Ile Lys Lys Met Leu Pro Phe Ser Arg Asn Cys Gln Lys 
                245                 250                 255     


Ser Ser Cys Leu Ser Arg Leu Leu 
            260                 


<210> 4892
<211> 58
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<400> 4892
Met Ala Asp Met Gln Asn Leu Val Glu Arg Leu Glu Arg Ala Val Gly 
1               5                   10                  15      


Arg Leu Glu Ala Val Ser His Xaa Ser Asp Met His Arg Gly Tyr Ala 
            20                  25                  30          


Asp Ser Pro Ser Lys Ala Gly Ala Ala Pro Tyr Val Gln Ala Phe Asp 
        35                  40                  45              


Ser Leu Leu Ala Gly Pro Val Ala Glu Tyr 
    50                  55              


<210> 4893
<211> 174
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 4893
Met Ala Asp Met Gln Asn Leu Val Glu Arg Leu Glu Arg Ala Val Gly 
1               5                   10                  15      


Arg Leu Glu Ala Val Ser His Xaa Ser Asp Met His Arg Gly Tyr Ala 
            20                  25                  30          


Asp Ser Pro Ser Lys Ala Gly Ala Ala Pro Tyr Val Gln Ala Phe Asp 
        35                  40                  45              


Ser Leu Leu Ala Gly Pro Val Ala Glu Tyr Leu Lys Ile Ser Lys Glu 
    50                  55                  60                  


Ile Gly Gly Asp Val Gln Lys His Ala Glu Met Val His Xaa Gly Leu 
65                  70                  75                  80  


Lys Leu Glu Arg Ala Leu Leu Val Xaa Ala Ser Gln Cys Gln Gln Pro 
                85                  90                  95      


Ala Glu Asn Lys Leu Ser Asp Leu Leu Ala Pro Ile Ser Glu Gln Ile 
            100                 105                 110         


Lys Glu Val Ile Xaa Phe Arg Glu Lys Asn Arg Gly Ser Lys Leu Phe 
        115                 120                 125             


Asn His Leu Ser Ala Val Ser Glu Ser Ile Gln Ala Leu Gly Trp Val 
    130                 135                 140                 


Ala Met Ala Pro Lys Pro Gly Pro Tyr Val Lys Glu Met Asn Asp Ala 
145                 150                 155                 160 


Ala Met Phe Tyr Xaa Asn Arg Val Leu Lys Glu Tyr Lys Asp 
                165                 170                 


<210> 4894
<211> 176
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 4894
Met Ala Asp Met Gln Asn Leu Val Glu Arg Leu Glu Arg Ala Val Gly 
1               5                   10                  15      


Arg Leu Glu Ala Val Ser His Xaa Ser Asp Met His Arg Gly Tyr Ala 
            20                  25                  30          


Asp Ser Pro Ser Lys Ala Gly Ala Ala Pro Tyr Val Gln Ala Phe Asp 
        35                  40                  45              


Ser Leu Leu Ala Gly Pro Val Ala Glu Tyr Leu Lys Ile Ser Lys Glu 
    50                  55                  60                  


Ile Gly Gly Asp Val Gln Lys His Ala Glu Met Val His Xaa Gly Leu 
65                  70                  75                  80  


Lys Leu Glu Arg Ala Leu Leu Val Xaa Ala Ser Gln Cys Gln Gln Pro 
                85                  90                  95      


Ala Glu Asn Lys Leu Ser Asp Leu Leu Ala Pro Ile Ser Glu Gln Ile 
            100                 105                 110         


Lys Glu Val Ile Xaa Phe Arg Glu Lys Asn Arg Gly Ser Lys Leu Phe 
        115                 120                 125             


Asn His Leu Ser Ala Val Ser Glu Ser Ile Gln Ala Leu Gly Trp Val 
    130                 135                 140                 


Ala Met Ala Pro Lys Pro Gly Pro Tyr Val Lys Glu Met Asn Asp Ala 
145                 150                 155                 160 


Ala Met Phe Tyr Xaa Asn Arg Val Leu Lys Glu Tyr Lys Asp Val Asp 
                165                 170                 175     


<210> 4895
<211> 180
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 4895
Met Ala Asp Met Gln Asn Leu Val Glu Arg Leu Glu Arg Ala Val Gly 
1               5                   10                  15      


Arg Leu Glu Ala Val Ser His Xaa Ser Asp Met His Arg Gly Tyr Ala 
            20                  25                  30          


Asp Ser Pro Ser Lys Ala Gly Ala Ala Pro Tyr Val Gln Ala Phe Asp 
        35                  40                  45              


Ser Leu Leu Ala Gly Pro Val Ala Glu Tyr Leu Lys Ile Ser Lys Glu 
    50                  55                  60                  


Ile Gly Gly Asp Val Gln Lys His Ala Glu Met Val His Xaa Gly Leu 
65                  70                  75                  80  


Lys Leu Glu Arg Ala Leu Leu Val Xaa Ala Ser Gln Cys Gln Gln Pro 
                85                  90                  95      


Ala Glu Asn Lys Leu Ser Asp Leu Leu Ala Pro Ile Ser Glu Gln Ile 
            100                 105                 110         


Lys Glu Val Ile Xaa Phe Arg Glu Lys Asn Arg Gly Ser Lys Leu Phe 
        115                 120                 125             


Asn His Leu Ser Ala Val Ser Glu Ser Ile Gln Ala Leu Gly Trp Val 
    130                 135                 140                 


Ala Met Ala Pro Lys Pro Gly Pro Tyr Val Lys Glu Met Asn Asp Ala 
145                 150                 155                 160 


Ala Met Phe Tyr Xaa Asn Arg Val Leu Lys Glu Tyr Lys Asp Val Asp 
                165                 170                 175     


Lys Lys His Val 
            180 


<210> 4896
<211> 202
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<400> 4896
Met Ala Asp Met Gln Asn Leu Val Glu Arg Leu Glu Arg Ala Val Gly 
1               5                   10                  15      


Arg Leu Glu Ala Val Ser His Xaa Ser Asp Met His Arg Gly Tyr Ala 
            20                  25                  30          


Asp Ser Pro Ser Lys Ala Gly Ala Ala Pro Tyr Val Gln Ala Phe Asp 
        35                  40                  45              


Ser Leu Leu Ala Gly Pro Val Ala Glu Tyr Leu Lys Ile Ser Lys Glu 
    50                  55                  60                  


Ile Gly Gly Asp Val Gln Lys His Ala Glu Met Val His Xaa Gly Leu 
65                  70                  75                  80  


Lys Leu Glu Arg Ala Leu Leu Val Xaa Ala Ser Gln Cys Gln Gln Pro 
                85                  90                  95      


Ala Glu Asn Lys Leu Ser Asp Leu Leu Ala Pro Ile Ser Glu Gln Ile 
            100                 105                 110         


Lys Glu Val Ile Xaa Phe Arg Glu Lys Asn Arg Gly Ser Lys Leu Phe 
        115                 120                 125             


Asn His Leu Ser Ala Val Ser Glu Ser Ile Gln Ala Leu Gly Trp Val 
    130                 135                 140                 


Ala Met Ala Pro Lys Pro Gly Pro Tyr Val Lys Glu Met Asn Asp Ala 
145                 150                 155                 160 


Ala Met Phe Tyr Xaa Asn Arg Val Leu Lys Glu Tyr Lys Asp Val Asp 
                165                 170                 175     


Lys Lys His Val Asp Trp Val Lys Ala Tyr Leu Ser Ile Trp Xaa Glu 
            180                 185                 190         


Leu Gln Ala Tyr Ile Lys Glu Phe His Xaa 
        195                 200         


<210> 4897
<211> 203
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(203)
<223> Selenocysteine

<400> 4897
Met Ala Asp Met Gln Asn Leu Val Glu Arg Leu Glu Arg Ala Val Gly 
1               5                   10                  15      


Arg Leu Glu Ala Val Ser His Xaa Ser Asp Met His Arg Gly Tyr Ala 
            20                  25                  30          


Asp Ser Pro Ser Lys Ala Gly Ala Ala Pro Tyr Val Gln Ala Phe Asp 
        35                  40                  45              


Ser Leu Leu Ala Gly Pro Val Ala Glu Tyr Leu Lys Ile Ser Lys Glu 
    50                  55                  60                  


Ile Gly Gly Asp Val Gln Lys His Ala Glu Met Val His Xaa Gly Leu 
65                  70                  75                  80  


Lys Leu Glu Arg Ala Leu Leu Val Xaa Ala Ser Gln Cys Gln Gln Pro 
                85                  90                  95      


Ala Glu Asn Lys Leu Ser Asp Leu Leu Ala Pro Ile Ser Glu Gln Ile 
            100                 105                 110         


Lys Glu Val Ile Xaa Phe Arg Glu Lys Asn Arg Gly Ser Lys Leu Phe 
        115                 120                 125             


Asn His Leu Ser Ala Val Ser Glu Ser Ile Gln Ala Leu Gly Trp Val 
    130                 135                 140                 


Ala Met Ala Pro Lys Pro Gly Pro Tyr Val Lys Glu Met Asn Asp Ala 
145                 150                 155                 160 


Ala Met Phe Tyr Xaa Asn Arg Val Leu Lys Glu Tyr Lys Asp Val Asp 
                165                 170                 175     


Lys Lys His Val Asp Trp Val Lys Ala Tyr Leu Ser Ile Trp Xaa Glu 
            180                 185                 190         


Leu Gln Ala Tyr Ile Lys Glu Phe His Xaa Xaa 
        195                 200             


<210> 4898
<211> 208
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(203)
<223> Selenocysteine

<400> 4898
Met Ala Asp Met Gln Asn Leu Val Glu Arg Leu Glu Arg Ala Val Gly 
1               5                   10                  15      


Arg Leu Glu Ala Val Ser His Xaa Ser Asp Met His Arg Gly Tyr Ala 
            20                  25                  30          


Asp Ser Pro Ser Lys Ala Gly Ala Ala Pro Tyr Val Gln Ala Phe Asp 
        35                  40                  45              


Ser Leu Leu Ala Gly Pro Val Ala Glu Tyr Leu Lys Ile Ser Lys Glu 
    50                  55                  60                  


Ile Gly Gly Asp Val Gln Lys His Ala Glu Met Val His Xaa Gly Leu 
65                  70                  75                  80  


Lys Leu Glu Arg Ala Leu Leu Val Xaa Ala Ser Gln Cys Gln Gln Pro 
                85                  90                  95      


Ala Glu Asn Lys Leu Ser Asp Leu Leu Ala Pro Ile Ser Glu Gln Ile 
            100                 105                 110         


Lys Glu Val Ile Xaa Phe Arg Glu Lys Asn Arg Gly Ser Lys Leu Phe 
        115                 120                 125             


Asn His Leu Ser Ala Val Ser Glu Ser Ile Gln Ala Leu Gly Trp Val 
    130                 135                 140                 


Ala Met Ala Pro Lys Pro Gly Pro Tyr Val Lys Glu Met Asn Asp Ala 
145                 150                 155                 160 


Ala Met Phe Tyr Xaa Asn Arg Val Leu Lys Glu Tyr Lys Asp Val Asp 
                165                 170                 175     


Lys Lys His Val Asp Trp Val Lys Ala Tyr Leu Ser Ile Trp Xaa Glu 
            180                 185                 190         


Leu Gln Ala Tyr Ile Lys Glu Phe His Xaa Xaa Gly Leu Ala Trp Ser 
        195                 200                 205             


<210> 4899
<211> 215
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<400> 4899
Met Ala Asp Met Gln Asn Leu Val Glu Arg Leu Glu Arg Ala Val Gly 
1               5                   10                  15      


Arg Leu Glu Ala Val Ser His Xaa Ser Asp Met His Arg Gly Tyr Ala 
            20                  25                  30          


Asp Ser Pro Ser Lys Ala Gly Ala Ala Pro Tyr Val Gln Ala Phe Asp 
        35                  40                  45              


Ser Leu Leu Ala Gly Pro Val Ala Glu Tyr Leu Lys Ile Ser Lys Glu 
    50                  55                  60                  


Ile Gly Gly Asp Val Gln Lys His Ala Glu Met Val His Xaa Gly Leu 
65                  70                  75                  80  


Lys Leu Glu Arg Ala Leu Leu Val Xaa Ala Ser Gln Cys Gln Gln Pro 
                85                  90                  95      


Ala Glu Asn Lys Leu Ser Asp Leu Leu Ala Pro Ile Ser Glu Gln Ile 
            100                 105                 110         


Lys Glu Val Ile Xaa Phe Arg Glu Lys Asn Arg Gly Ser Lys Leu Phe 
        115                 120                 125             


Asn His Leu Ser Ala Val Ser Glu Ser Ile Gln Ala Leu Gly Trp Val 
    130                 135                 140                 


Ala Met Ala Pro Lys Pro Gly Pro Tyr Val Lys Glu Met Asn Asp Ala 
145                 150                 155                 160 


Ala Met Phe Tyr Xaa Asn Arg Val Leu Lys Glu Tyr Lys Asp Val Asp 
                165                 170                 175     


Lys Lys His Val Asp Trp Val Lys Ala Tyr Leu Ser Ile Trp Xaa Glu 
            180                 185                 190         


Leu Gln Ala Tyr Ile Lys Glu Phe His Xaa Xaa Gly Leu Ala Trp Ser 
        195                 200                 205             


Lys Xaa Gly Pro Val Ala Lys 
    210                 215 


<210> 4900
<211> 475
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<400> 4900
Met Ala Asp Met Gln Asn Leu Val Glu Arg Leu Glu Arg Ala Val Gly 
1               5                   10                  15      


Arg Leu Glu Ala Val Ser His Xaa Ser Asp Met His Arg Gly Tyr Ala 
            20                  25                  30          


Asp Ser Pro Ser Lys Ala Gly Ala Ala Pro Tyr Val Gln Ala Phe Asp 
        35                  40                  45              


Ser Leu Leu Ala Gly Pro Val Ala Glu Tyr Leu Lys Ile Ser Lys Glu 
    50                  55                  60                  


Ile Gly Gly Asp Val Gln Lys His Ala Glu Met Val His Xaa Gly Leu 
65                  70                  75                  80  


Lys Leu Glu Arg Ala Leu Leu Val Xaa Ala Ser Gln Cys Gln Gln Pro 
                85                  90                  95      


Ala Glu Asn Lys Leu Ser Asp Leu Leu Ala Pro Ile Ser Glu Gln Ile 
            100                 105                 110         


Lys Glu Val Ile Xaa Phe Arg Glu Lys Asn Arg Gly Ser Lys Leu Phe 
        115                 120                 125             


Asn His Leu Ser Ala Val Ser Glu Ser Ile Gln Ala Leu Gly Trp Val 
    130                 135                 140                 


Ala Met Ala Pro Lys Pro Gly Pro Tyr Val Lys Glu Met Asn Asp Ala 
145                 150                 155                 160 


Ala Met Phe Tyr Xaa Asn Arg Val Leu Lys Glu Tyr Lys Asp Val Asp 
                165                 170                 175     


Lys Lys His Val Asp Trp Val Lys Ala Tyr Leu Ser Ile Trp Xaa Glu 
            180                 185                 190         


Leu Gln Ala Tyr Ile Lys Glu Phe His Xaa Xaa Gly Leu Ala Trp Ser 
        195                 200                 205             


Lys Xaa Gly Pro Val Ala Lys Glu Leu Ser Gly Leu Pro Ser Gly Pro 
    210                 215                 220                 


Ser Ala Gly Ser Cys Pro Pro Pro Pro Pro Pro Cys Pro Pro Pro Pro 
225                 230                 235                 240 


Pro Val Ser Xaa Ile Ser Cys Ser Tyr Glu Ser Ala Ser Arg Ser Ser 
                245                 250                 255     


Leu Phe Ala Gln Ile Asn Gln Gly Glu Ser Ile Xaa His Ala Leu Lys 
            260                 265                 270         


His Val Ser Asp Asp Met Lys Xaa His Lys Asn Pro Ala Leu Lys Ala 
        275                 280                 285             


Gln Ser Gly Pro Val Arg Ser Gly Pro Lys Pro Phe Ser Ala Pro Lys 
    290                 295                 300                 


Pro Gln Xaa Ser Pro Ser Pro Lys Arg Ala Xaa Lys Lys Glu Pro Ala 
305                 310                 315                 320 


Val Leu Glu Leu Glu Gly Lys Lys Trp Arg Val Glu Asn Gln Glu Asn 
                325                 330                 335     


Val Ser Asn Leu Val Ile Glu Asp Xaa Glu Leu Lys Gln Val Ala Tyr 
            340                 345                 350         


Ile Tyr Lys Cys Val Asn Xaa Xaa Leu Gln Ile Lys Gly Lys Ile Asn 
        355                 360                 365             


Ser Ile Xaa Val Asp Asn Cys Lys Lys Leu Gly Leu Val Phe Asp Asp 
    370                 375                 380                 


Val Val Gly Ile Val Glu Ile Ile Asn Ser Lys Asp Val Lys Val Gln 
385                 390                 395                 400 


Val Met Gly Lys Val Pro Xaa Ile Ser Ile Asn Lys Xaa Asp Gly Cys 
                405                 410                 415     


His Ala Tyr Leu Ser Lys Asn Ser Leu Asp Cys Glu Ile Val Ser Ala 
            420                 425                 430         


Lys Ser Ser Glu Met Asn Val Leu Ile Pro Xaa Glu Gly Gly Asp Phe 
        435                 440                 445             


Asn Glu Phe Pro Val Pro Glu Gln Phe Lys Xaa Leu Trp Asn Gly Gln 
    450                 455                 460                 


Lys Leu Val Xaa Xaa Val Xaa Glu Ile Ala Gly 
465                 470                 475 


<210> 4901
<211> 145
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<400> 4901
Met Ala Asp Met Gln Asn Leu Val Glu Arg Leu Glu Arg Ala Val Gly 
1               5                   10                  15      


Arg Leu Glu Ala Val Ser His Xaa Ser Asp Met His Arg Gly Tyr Ala 
            20                  25                  30          


Asp Ser Pro Ser Lys Ala Gly Ala Ala Pro Tyr Val Gln Ala Tyr Ile 
        35                  40                  45              


Lys Glu Phe His Xaa Xaa Gly Leu Ala Trp Ser Lys Xaa Gly Pro Val 
    50                  55                  60                  


Ala Lys Glu Leu Ser Gly Leu Pro Ser Gly Pro Ser Ala Gly Ser Cys 
65                  70                  75                  80  


Pro Pro Pro Pro Pro Pro Cys Pro Pro Pro Pro Pro Val Ser Xaa Ile 
                85                  90                  95      


Ser Cys Ser Tyr Glu Ser Ala Ser Arg Ser Ser Leu Phe Ala Gln Ile 
            100                 105                 110         


Asn Gln Gly Glu Ser Ile Xaa His Ala Leu Lys His Val Ser Asp Asp 
        115                 120                 125             


Met Lys Xaa His Lys Asn Pro Ala Leu Lys Ala Gln Ser Gly Pro Val 
    130                 135                 140                 


Arg 
145 


<210> 4902
<211> 263
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<400> 4902
Met Ala Asp Met Gln Asn Leu Val Glu Arg Leu Glu Arg Ala Val Gly 
1               5                   10                  15      


Arg Leu Glu Ala Val Ser His Xaa Ser Asp Met His Arg Gly Tyr Ala 
            20                  25                  30          


Asp Ser Pro Ser Lys Gly Ala Ala Pro Tyr Val Gln Ala Phe Asp Ser 
        35                  40                  45              


Leu Leu Ala Gly Pro Val Ala Glu Tyr Leu Lys Ile Ser Lys Glu Ile 
    50                  55                  60                  


Gly Gly Asp Val Gln Lys His Ala Glu Met Val His Xaa Gly Leu Lys 
65                  70                  75                  80  


Leu Glu Arg Ala Leu Leu Val Xaa Ala Ser Gln Cys Gln Gln Pro Ala 
                85                  90                  95      


Glu Asn Lys Leu Ser Asp Leu Leu Ala Pro Ile Ser Glu Gln Ile Lys 
            100                 105                 110         


Glu Val Ile Xaa Phe Arg Glu Lys Asn Arg Gly Ser Lys Leu Phe Asn 
        115                 120                 125             


His Leu Ser Ala Val Ser Glu Ser Ile Gln Ala Leu Gly Trp Val Ala 
    130                 135                 140                 


Met Ala Pro Lys Pro Gly Pro Tyr Val Lys Glu Met Asn Asp Ala Ala 
145                 150                 155                 160 


Met Phe Tyr Xaa Asn Arg Val Leu Lys Glu Tyr Lys Asp Val Asp Lys 
                165                 170                 175     


Lys His Val Asp Trp Val Lys Ala Tyr Leu Ser Ile Trp Xaa Glu Leu 
            180                 185                 190         


Gln Ala Tyr Ile Lys Glu Phe His Xaa Xaa Gly Leu Ala Trp Ser Lys 
        195                 200                 205             


Xaa Gly Pro Val Ala Lys Glu Leu Ser Gly Leu Pro Ser Gly Pro Ser 
    210                 215                 220                 


Ala Gly Ser Cys Pro Pro Pro Pro Pro Pro Cys Pro Pro Pro Pro Pro 
225                 230                 235                 240 


Val Ser Xaa Ile Ser Cys Ser Tyr Glu Ser Ala Ser Arg Ser Ser Leu 
                245                 250                 255     


Phe Ala Gln Ile Asn Gln Gly 
            260             


<210> 4903
<211> 474
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<400> 4903
Met Ala Asp Met Gln Asn Leu Val Glu Arg Leu Glu Arg Ala Val Gly 
1               5                   10                  15      


Arg Leu Glu Ala Val Ser His Xaa Ser Asp Met His Arg Gly Tyr Ala 
            20                  25                  30          


Asp Ser Pro Ser Lys Gly Ala Ala Pro Tyr Val Gln Ala Phe Asp Ser 
        35                  40                  45              


Leu Leu Ala Gly Pro Val Ala Glu Tyr Leu Lys Ile Ser Lys Glu Ile 
    50                  55                  60                  


Gly Gly Asp Val Gln Lys His Ala Glu Met Val His Xaa Gly Leu Lys 
65                  70                  75                  80  


Leu Glu Arg Ala Leu Leu Val Xaa Ala Ser Gln Cys Gln Gln Pro Ala 
                85                  90                  95      


Glu Asn Lys Leu Ser Asp Leu Leu Ala Pro Ile Ser Glu Gln Ile Lys 
            100                 105                 110         


Glu Val Ile Xaa Phe Arg Glu Lys Asn Arg Gly Ser Lys Leu Phe Asn 
        115                 120                 125             


His Leu Ser Ala Val Ser Glu Ser Ile Gln Ala Leu Gly Trp Val Ala 
    130                 135                 140                 


Met Ala Pro Lys Pro Gly Pro Tyr Val Lys Glu Met Asn Asp Ala Ala 
145                 150                 155                 160 


Met Phe Tyr Xaa Asn Arg Val Leu Lys Glu Tyr Lys Asp Val Asp Lys 
                165                 170                 175     


Lys His Val Asp Trp Val Lys Ala Tyr Leu Ser Ile Trp Xaa Glu Leu 
            180                 185                 190         


Gln Ala Tyr Ile Lys Glu Phe His Xaa Xaa Gly Leu Ala Trp Ser Lys 
        195                 200                 205             


Xaa Gly Pro Val Ala Lys Glu Leu Ser Gly Leu Pro Ser Gly Pro Ser 
    210                 215                 220                 


Ala Gly Ser Cys Pro Pro Pro Pro Pro Pro Cys Pro Pro Pro Pro Pro 
225                 230                 235                 240 


Val Ser Xaa Ile Ser Cys Ser Tyr Glu Ser Ala Ser Arg Ser Ser Leu 
                245                 250                 255     


Phe Ala Gln Ile Asn Gln Gly Glu Ser Ile Xaa His Ala Leu Lys His 
            260                 265                 270         


Val Ser Asp Asp Met Lys Xaa His Lys Asn Pro Ala Leu Lys Ala Gln 
        275                 280                 285             


Ser Gly Pro Val Arg Ser Gly Pro Lys Pro Phe Ser Ala Pro Lys Pro 
    290                 295                 300                 


Gln Xaa Ser Pro Ser Pro Lys Arg Ala Xaa Lys Lys Glu Pro Ala Val 
305                 310                 315                 320 


Leu Glu Leu Glu Gly Lys Lys Trp Arg Val Glu Asn Gln Glu Asn Val 
                325                 330                 335     


Ser Asn Leu Val Ile Glu Asp Xaa Glu Leu Lys Gln Val Ala Tyr Ile 
            340                 345                 350         


Tyr Lys Cys Val Asn Xaa Xaa Leu Gln Ile Lys Gly Lys Ile Asn Ser 
        355                 360                 365             


Ile Xaa Val Asp Asn Cys Lys Lys Leu Gly Leu Val Phe Asp Asp Val 
    370                 375                 380                 


Val Gly Ile Val Glu Ile Ile Asn Ser Lys Asp Val Lys Val Gln Val 
385                 390                 395                 400 


Met Gly Lys Val Pro Xaa Ile Ser Ile Asn Lys Xaa Asp Gly Cys His 
                405                 410                 415     


Ala Tyr Leu Ser Lys Asn Ser Leu Asp Cys Glu Ile Val Ser Ala Lys 
            420                 425                 430         


Ser Ser Glu Met Asn Val Leu Ile Pro Xaa Glu Gly Gly Asp Phe Asn 
        435                 440                 445             


Glu Phe Pro Val Pro Glu Gln Phe Lys Xaa Leu Trp Asn Gly Gln Lys 
    450                 455                 460                 


Leu Val Xaa Xaa Val Xaa Glu Ile Ala Gly 
465                 470                 


<210> 4904
<211> 104
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<400> 4904
Met Ala Asn Met Gln Gly Leu Val Glu Arg Leu Glu Arg Ala Val Ser 
1               5                   10                  15      


Arg Leu Glu Ser Leu Ser Ala Glu Ser His Arg Pro Pro Gly Asn Cys 
            20                  25                  30          


Gly Glu Val Asn Gly Val Ile Ala Gly Val Ala Pro Ser Val Glu Ala 
        35                  40                  45              


Phe Asp Lys Leu Met Asp Ser Met Val Ala Glu Phe Leu Lys Asn Ser 
    50                  55                  60                  


Arg Ile Leu Ala Gly Asp Val Glu Xaa His Ala Glu Met Val His Ser 
65                  70                  75                  80  


Ala Phe Gln Ala Gln Arg Ala Phe Leu Leu Met Ala Ser Gln Tyr Gln 
                85                  90                  95      


Gln Pro His Glu Ala Asn Lys Phe 
            100                 


<210> 4905
<211> 365
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<400> 4905
Met Ala Asn Met Gln Gly Leu Val Glu Arg Leu Glu Arg Ala Val Ser 
1               5                   10                  15      


Arg Leu Glu Ser Leu Ser Ala Glu Ser His Arg Pro Pro Gly Asn Cys 
            20                  25                  30          


Gly Glu Val Asn Gly Val Ile Ala Gly Val Ala Pro Ser Val Glu Ala 
        35                  40                  45              


Phe Asp Lys Leu Met Asp Ser Met Val Ala Glu Phe Leu Lys Asn Ser 
    50                  55                  60                  


Arg Ile Leu Ala Gly Asp Val Glu Xaa His Ala Glu Met Val His Ser 
65                  70                  75                  80  


Ala Phe Gln Ala Gln Arg Ala Phe Leu Leu Met Ala Ser Gln Tyr Gln 
                85                  90                  95      


Gln Pro His Glu Gly Pro Val Ala Ser Xaa Val Ser Ala Phe Ser Val 
            100                 105                 110         


Leu Ser Ser Gly Pro Gly Leu Pro Pro Pro Pro Pro Pro Leu Pro Pro 
        115                 120                 125             


Pro Gly Pro Pro Pro Leu Phe Glu Asn Glu Gly Lys Lys Glu Glu Ser 
    130                 135                 140                 


Ser Pro Ser Arg Ser Ala Leu Phe Ala Gln Leu Asn Gln Gly Glu Ala 
145                 150                 155                 160 


Ile Xaa Lys Gly Leu Arg His Val Xaa Asp Asp Gln Lys Xaa Tyr Lys 
                165                 170                 175     


Asn Pro Ser Leu Arg Ala Gln Gly Gly Gln Xaa Gln Ser Pro Xaa Lys 
            180                 185                 190         


Ser His Xaa Pro Ser Pro Xaa Ser Pro Lys Ser Tyr Pro Ser Gln Lys 
        195                 200                 205             


His Ala Pro Val Leu Glu Leu Glu Gly Lys Lys Trp Arg Val Glu Tyr 
    210                 215                 220                 


Gln Glu Asp Arg Asn Asp Leu Val Ile Ser Glu Xaa Glu Leu Lys Gln 
225                 230                 235                 240 


Val Ala Tyr Ile Phe Lys Cys Glu Lys Ser Xaa Ile Gln Ile Lys Gly 
                245                 250                 255     


Lys Val Asn Ser Ile Ile Ile Asp Asn Cys Lys Lys Leu Gly Leu Val 
            260                 265                 270         


Phe Asp Asn Val Val Gly Ile Val Glu Val Ile Asn Ser Gln Asp Ile 
        275                 280                 285             


Gln Ile Gln Val Met Gly Arg Val Pro Xaa Ile Ser Ile Asn Lys Xaa 
    290                 295                 300                 


Glu Gly Cys His Ile Tyr Leu Ser Glu Asp Ala Leu Asp Cys Glu Ile 
305                 310                 315                 320 


Val Ser Ala Lys Ser Ser Glu Met Asn Ile Leu Ile Pro Gln Asp Gly 
                325                 330                 335     


Asp Tyr Arg Glu Phe Pro Ile Pro Glu Gln Phe Lys Xaa Ala Trp Asp 
            340                 345                 350         


Gly Ser Lys Leu Ile Xaa Glu Pro Ala Glu Ile Met Ala 
        355                 360                 365 


<210> 4906
<211> 413
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<400> 4906
Met Ala Asn Met Gln Gly Leu Val Glu Arg Leu Glu Arg Ala Val Ser 
1               5                   10                  15      


Arg Leu Glu Ser Leu Ser Ala Glu Ser His Arg Pro Pro Gly Asn Cys 
            20                  25                  30          


Gly Glu Val Asn Gly Val Ile Ala Gly Val Ala Pro Ser Val Glu Ala 
        35                  40                  45              


Phe Asp Lys Leu Met Asp Ser Met Val Ala Glu Phe Leu Lys Asn Ser 
    50                  55                  60                  


Arg Ile Leu Ala Gly Asp Val Glu Xaa His Ala Glu Met Val His Ser 
65                  70                  75                  80  


Ala Phe Gln Ala Gln Arg Ala Phe Leu Leu Met Ala Ser Gln Tyr Gln 
                85                  90                  95      


Gln Pro His Glu Asn Asp Val Ala Ala Leu Leu Lys Pro Ile Ser Glu 
            100                 105                 110         


Lys Ile Gln Glu Ile Gln Xaa Phe Arg Glu Arg Asn Arg Gly Ser Asn 
        115                 120                 125             


Met Phe Asn His Leu Ser Ala Val Ser Glu Ser Ile Pro Ala Leu Gly 
    130                 135                 140                 


Trp Ile Ala Val Gly Pro Val Ala Ser Xaa Val Ser Ala Phe Ser Val 
145                 150                 155                 160 


Leu Ser Ser Gly Pro Gly Leu Pro Pro Pro Pro Pro Pro Leu Pro Pro 
                165                 170                 175     


Pro Gly Pro Pro Pro Leu Phe Glu Asn Glu Gly Lys Lys Glu Glu Ser 
            180                 185                 190         


Ser Pro Ser Arg Ser Ala Leu Phe Ala Gln Leu Asn Gln Gly Glu Ala 
        195                 200                 205             


Ile Xaa Lys Gly Leu Arg His Val Xaa Asp Asp Gln Lys Xaa Tyr Lys 
    210                 215                 220                 


Asn Pro Ser Leu Arg Ala Gln Gly Gly Gln Xaa Gln Ser Pro Xaa Lys 
225                 230                 235                 240 


Ser His Xaa Pro Ser Pro Xaa Ser Pro Lys Ser Tyr Pro Ser Gln Lys 
                245                 250                 255     


His Ala Pro Val Leu Glu Leu Glu Gly Lys Lys Trp Arg Val Glu Tyr 
            260                 265                 270         


Gln Glu Asp Arg Asn Asp Leu Val Ile Ser Glu Xaa Glu Leu Lys Gln 
        275                 280                 285             


Val Ala Tyr Ile Phe Lys Cys Glu Lys Ser Xaa Ile Gln Ile Lys Gly 
    290                 295                 300                 


Lys Val Asn Ser Ile Ile Ile Asp Asn Cys Lys Lys Leu Gly Leu Val 
305                 310                 315                 320 


Phe Asp Asn Val Val Gly Ile Val Glu Val Ile Asn Ser Gln Asp Ile 
                325                 330                 335     


Gln Ile Gln Val Met Gly Arg Val Pro Xaa Ile Ser Ile Asn Lys Xaa 
            340                 345                 350         


Glu Gly Cys His Ile Tyr Leu Ser Glu Asp Ala Leu Asp Cys Glu Ile 
        355                 360                 365             


Val Ser Ala Lys Ser Ser Glu Met Asn Ile Leu Ile Pro Gln Asp Gly 
    370                 375                 380                 


Asp Tyr Arg Glu Phe Pro Ile Pro Glu Gln Phe Lys Xaa Ala Trp Asp 
385                 390                 395                 400 


Gly Ser Lys Leu Ile Xaa Glu Pro Ala Glu Ile Met Ala 
                405                 410             


<210> 4907
<211> 394
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<400> 4907
Met Ala Asn Met Gln Gly Leu Val Glu Arg Leu Glu Arg Ala Val Ser 
1               5                   10                  15      


Arg Leu Glu Ser Leu Ser Ala Glu Ser His Arg Pro Pro Gly Asn Cys 
            20                  25                  30          


Gly Glu Val Asn Gly Val Ile Ala Gly Val Ala Pro Ser Val Glu Ala 
        35                  40                  45              


Phe Asp Lys Leu Met Asp Ser Met Val Ala Glu Phe Leu Lys Asn Ser 
    50                  55                  60                  


Arg Ile Leu Ala Gly Asp Val Glu Xaa His Ala Glu Met Val His Ser 
65                  70                  75                  80  


Ala Phe Gln Ala Gln Arg Ala Phe Leu Leu Met Ala Ser Gln Tyr Gln 
                85                  90                  95      


Gln Pro His Glu Asn Asp Val Ala Ala Leu Leu Lys Pro Ile Ser Glu 
            100                 105                 110         


Lys Ile Gln Glu Ile Gln Xaa Phe Arg Glu Arg Asn Arg Gly Ser Asn 
        115                 120                 125             


Met Phe Asn His Leu Ser Ala Val Ser Glu Ser Ile Pro Ala Leu Gly 
    130                 135                 140                 


Trp Ile Ala Val Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro Gly Pro 
145                 150                 155                 160 


Pro Pro Leu Phe Glu Asn Glu Gly Lys Lys Glu Glu Ser Ser Pro Ser 
                165                 170                 175     


Arg Ser Ala Leu Phe Ala Gln Leu Asn Gln Gly Glu Ala Ile Xaa Lys 
            180                 185                 190         


Gly Leu Arg His Val Xaa Asp Asp Gln Lys Xaa Tyr Lys Asn Pro Ser 
        195                 200                 205             


Leu Arg Ala Gln Gly Gly Gln Xaa Gln Ser Pro Xaa Lys Ser His Xaa 
    210                 215                 220                 


Pro Ser Pro Xaa Ser Pro Lys Ser Tyr Pro Ser Gln Lys His Ala Pro 
225                 230                 235                 240 


Val Leu Glu Leu Glu Gly Lys Lys Trp Arg Val Glu Tyr Gln Glu Asp 
                245                 250                 255     


Arg Asn Asp Leu Val Ile Ser Glu Xaa Glu Leu Lys Gln Val Ala Tyr 
            260                 265                 270         


Ile Phe Lys Cys Glu Lys Ser Xaa Ile Gln Ile Lys Gly Lys Val Asn 
        275                 280                 285             


Ser Ile Ile Ile Asp Asn Cys Lys Lys Leu Gly Leu Val Phe Asp Asn 
    290                 295                 300                 


Val Val Gly Ile Val Glu Val Ile Asn Ser Gln Asp Ile Gln Ile Gln 
305                 310                 315                 320 


Val Met Gly Arg Val Pro Xaa Ile Ser Ile Asn Lys Xaa Glu Gly Cys 
                325                 330                 335     


His Ile Tyr Leu Ser Glu Asp Ala Leu Asp Cys Glu Ile Val Ser Ala 
            340                 345                 350         


Lys Ser Ser Glu Met Asn Ile Leu Ile Pro Gln Asp Gly Asp Tyr Arg 
        355                 360                 365             


Glu Phe Pro Ile Pro Glu Gln Phe Lys Xaa Ala Trp Asp Gly Ser Lys 
    370                 375                 380                 


Leu Ile Xaa Glu Pro Ala Glu Ile Met Ala 
385                 390                 


<210> 4908
<211> 477
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<400> 4908
Met Ala Asn Met Gln Gly Leu Val Glu Arg Leu Glu Arg Ala Val Ser 
1               5                   10                  15      


Arg Leu Glu Ser Leu Ser Ala Glu Ser His Arg Pro Pro Gly Asn Cys 
            20                  25                  30          


Gly Glu Val Asn Gly Val Ile Ala Gly Val Ala Pro Ser Val Glu Ala 
        35                  40                  45              


Phe Asp Lys Leu Met Asp Ser Met Val Ala Glu Phe Leu Lys Asn Ser 
    50                  55                  60                  


Arg Ile Leu Ala Gly Asp Val Glu Xaa His Ala Glu Met Val His Ser 
65                  70                  75                  80  


Ala Phe Gln Ala Gln Arg Ala Phe Leu Leu Met Ala Ser Gln Tyr Gln 
                85                  90                  95      


Gln Pro His Glu Asn Asp Val Ala Ala Leu Leu Lys Pro Ile Ser Glu 
            100                 105                 110         


Lys Ile Gln Glu Ile Gln Xaa Phe Arg Glu Arg Asn Arg Gly Ser Asn 
        115                 120                 125             


Met Phe Asn His Leu Ser Ala Val Ser Glu Ser Ile Pro Ala Leu Gly 
    130                 135                 140                 


Trp Ile Ala Val Ser Pro Lys Pro Gly Pro Tyr Val Lys Glu Met Asn 
145                 150                 155                 160 


Asp Ala Ala Xaa Phe Tyr Xaa Asn Arg Val Leu Lys Asp Tyr Lys His 
                165                 170                 175     


Ser Asp Leu Arg His Val Asp Trp Val Lys Ser Tyr Leu Asn Ile Trp 
            180                 185                 190         


Ser Glu Leu Gln Ala Tyr Ile Lys Glu His His Xaa Xaa Gly Leu Xaa 
        195                 200                 205             


Trp Ser Lys Xaa Gly Pro Val Ala Ser Xaa Val Ser Ala Phe Ser Val 
    210                 215                 220                 


Leu Ser Ser Gly Pro Gly Leu Pro Pro Pro Pro Pro Pro Leu Pro Pro 
225                 230                 235                 240 


Pro Gly Pro Pro Pro Leu Phe Glu Asn Glu Gly Lys Lys Glu Glu Ser 
                245                 250                 255     


Ser Pro Ser Arg Ser Ala Leu Phe Ala Gln Leu Asn Gln Gly Glu Ala 
            260                 265                 270         


Ile Xaa Lys Gly Leu Arg His Val Xaa Asp Asp Gln Lys Xaa Tyr Lys 
        275                 280                 285             


Asn Pro Ser Leu Arg Ala Gln Gly Gly Gln Xaa Gln Ser Pro Xaa Lys 
    290                 295                 300                 


Ser His Xaa Pro Ser Pro Xaa Ser Pro Lys Ser Tyr Pro Ser Gln Lys 
305                 310                 315                 320 


His Ala Pro Val Leu Glu Leu Glu Gly Lys Lys Trp Arg Val Glu Tyr 
                325                 330                 335     


Gln Glu Asp Arg Asn Asp Leu Val Ile Ser Glu Xaa Glu Leu Lys Gln 
            340                 345                 350         


Val Ala Tyr Ile Phe Lys Cys Glu Lys Ser Xaa Ile Gln Ile Lys Gly 
        355                 360                 365             


Lys Val Asn Ser Ile Ile Ile Asp Asn Cys Lys Lys Leu Gly Leu Val 
    370                 375                 380                 


Phe Asp Asn Val Val Gly Ile Val Glu Val Ile Asn Ser Gln Asp Ile 
385                 390                 395                 400 


Gln Ile Gln Val Met Gly Arg Val Pro Xaa Ile Ser Ile Asn Lys Xaa 
                405                 410                 415     


Glu Gly Cys His Ile Tyr Leu Ser Glu Asp Ala Leu Asp Cys Glu Ile 
            420                 425                 430         


Val Ser Ala Lys Ser Ser Glu Met Asn Ile Leu Ile Pro Gln Asp Gly 
        435                 440                 445             


Asp Tyr Arg Glu Phe Pro Ile Pro Glu Gln Phe Lys Xaa Ala Trp Asp 
    450                 455                 460                 


Gly Ser Lys Leu Ile Xaa Glu Pro Ala Glu Ile Met Ala 
465                 470                 475         


<210> 4909
<211> 394
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<400> 4909
Met Ala Asn Met Gln Gly Leu Val Glu Arg Leu Glu Arg Ala Val Ser 
1               5                   10                  15      


Arg Leu Glu Ser Leu Ser Ala Glu Ser His Arg Pro Pro Gly Asn Cys 
            20                  25                  30          


Gly Glu Val Asn Gly Val Ile Ala Gly Val Ala Pro Ser Val Glu Ala 
        35                  40                  45              


Phe Asp Lys Leu Met Asp Ser Met Val Ala Glu Phe Leu Lys Asn Ser 
    50                  55                  60                  


Arg Ile Leu Ala Gly Asp Val Glu Xaa His Ala Glu Met Val His Ser 
65                  70                  75                  80  


Ala Phe Gln Ala Gln Arg Ala Phe Leu Leu Met Ala Ser Gln Tyr Gln 
                85                  90                  95      


Gln Pro His Glu Asn Asp Val Ala Ala Leu Leu Lys Pro Ile Ser Glu 
            100                 105                 110         


Lys Ile Gln Glu Ile Gln Xaa Phe Arg Glu Arg Asn Arg Gly Ser Asn 
        115                 120                 125             


Met Phe Asn His Leu Ser Ala Val Ser Glu Ser Ile Pro Ala Leu Gly 
    130                 135                 140                 


Trp Ile Ala Val Ser Pro Lys Pro Pro Pro Leu Pro Pro Pro Gly Pro 
145                 150                 155                 160 


Pro Pro Leu Phe Glu Asn Glu Gly Lys Lys Glu Glu Ser Ser Pro Ser 
                165                 170                 175     


Arg Ser Ala Leu Phe Ala Gln Leu Asn Gln Gly Glu Ala Ile Xaa Lys 
            180                 185                 190         


Gly Leu Arg His Val Xaa Asp Asp Gln Lys Xaa Tyr Lys Asn Pro Ser 
        195                 200                 205             


Leu Arg Ala Gln Gly Gly Gln Xaa Gln Ser Pro Xaa Lys Ser His Xaa 
    210                 215                 220                 


Pro Ser Pro Xaa Ser Pro Lys Ser Tyr Pro Ser Gln Lys His Ala Pro 
225                 230                 235                 240 


Val Leu Glu Leu Glu Gly Lys Lys Trp Arg Val Glu Tyr Gln Glu Asp 
                245                 250                 255     


Arg Asn Asp Leu Val Ile Ser Glu Xaa Glu Leu Lys Gln Val Ala Tyr 
            260                 265                 270         


Ile Phe Lys Cys Glu Lys Ser Xaa Ile Gln Ile Lys Gly Lys Val Asn 
        275                 280                 285             


Ser Ile Ile Ile Asp Asn Cys Lys Lys Leu Gly Leu Val Phe Asp Asn 
    290                 295                 300                 


Val Val Gly Ile Val Glu Val Ile Asn Ser Gln Asp Ile Gln Ile Gln 
305                 310                 315                 320 


Val Met Gly Arg Val Pro Xaa Ile Ser Ile Asn Lys Xaa Glu Gly Cys 
                325                 330                 335     


His Ile Tyr Leu Ser Glu Asp Ala Leu Asp Cys Glu Ile Val Ser Ala 
            340                 345                 350         


Lys Ser Ser Glu Met Asn Ile Leu Ile Pro Gln Asp Gly Asp Tyr Arg 
        355                 360                 365             


Glu Phe Pro Ile Pro Glu Gln Phe Lys Xaa Ala Trp Asp Gly Ser Lys 
    370                 375                 380                 


Leu Ile Xaa Glu Pro Ala Glu Ile Met Ala 
385                 390                 


<210> 4910
<211> 217
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<400> 4910
Met Ala Asn Met Gln Gly Leu Val Glu Arg Leu Glu Arg Ala Val Ser 
1               5                   10                  15      


Arg Leu Glu Ser Leu Ser Ala Glu Ser His Arg Pro Pro Gly Asn Cys 
            20                  25                  30          


Gly Glu Val Asn Gly Val Ile Ala Gly Val Ala Pro Ser Val Glu Ala 
        35                  40                  45              


Phe Asp Lys Leu Met Asp Ser Met Val Ala Glu Phe Leu Lys Asn Ser 
    50                  55                  60                  


Arg Ile Leu Ala Gly Asp Val Glu Xaa His Glu Tyr Gln Glu Asp Arg 
65                  70                  75                  80  


Asn Asp Leu Val Ile Ser Glu Xaa Glu Leu Lys Gln Val Ala Tyr Ile 
                85                  90                  95      


Phe Lys Cys Glu Lys Ser Xaa Ile Gln Ile Lys Gly Lys Val Asn Ser 
            100                 105                 110         


Ile Ile Ile Asp Asn Cys Lys Lys Leu Gly Leu Val Phe Asp Asn Val 
        115                 120                 125             


Val Gly Ile Val Glu Val Ile Asn Ser Gln Asp Ile Gln Ile Gln Val 
    130                 135                 140                 


Met Gly Arg Val Pro Xaa Ile Ser Ile Asn Lys Xaa Glu Gly Cys His 
145                 150                 155                 160 


Ile Tyr Leu Ser Glu Asp Ala Leu Asp Cys Glu Ile Val Ser Ala Lys 
                165                 170                 175     


Ser Ser Glu Met Asn Ile Leu Ile Pro Gln Asp Gly Asp Tyr Arg Glu 
            180                 185                 190         


Phe Pro Ile Pro Glu Gln Phe Lys Xaa Ala Trp Asp Gly Ser Lys Leu 
        195                 200                 205             


Ile Xaa Glu Pro Ala Glu Ile Met Ala 
    210                 215         


<210> 4911
<211> 451
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<400> 4911
Met Ala Asn Met Gln Gly Leu Val Glu Arg Leu Glu Arg Ala Val Ser 
1               5                   10                  15      


Arg Leu Glu Ser Leu Ser Ala Glu Ser His Arg Pro Pro Gly Asn Cys 
            20                  25                  30          


Gly Glu Val Asn Gly Val Ile Ala Gly Val Ala Pro Ser Val Glu Ala 
        35                  40                  45              


Phe Asp Lys Leu Met Asp Ser Met Val Ala Glu Phe Leu Lys Asn Ser 
    50                  55                  60                  


Arg Ile Leu Ala Gly Asp Val Glu Xaa His Asn Asp Val Ala Ala Leu 
65                  70                  75                  80  


Leu Lys Pro Ile Ser Glu Lys Ile Gln Glu Ile Gln Xaa Phe Arg Glu 
                85                  90                  95      


Arg Asn Arg Gly Ser Asn Met Phe Asn His Leu Ser Ala Val Ser Glu 
            100                 105                 110         


Ser Ile Pro Ala Leu Gly Trp Ile Ala Val Ser Pro Lys Pro Gly Pro 
        115                 120                 125             


Tyr Val Lys Glu Met Asn Asp Ala Ala Xaa Phe Tyr Xaa Asn Arg Val 
    130                 135                 140                 


Leu Lys Asp Tyr Lys His Ser Asp Leu Arg His Val Asp Trp Val Lys 
145                 150                 155                 160 


Ser Tyr Leu Asn Ile Trp Ser Glu Leu Gln Ala Tyr Ile Lys Glu His 
                165                 170                 175     


His Xaa Xaa Gly Leu Xaa Trp Ser Lys Xaa Gly Pro Val Ala Ser Xaa 
            180                 185                 190         


Val Ser Ala Phe Ser Val Leu Ser Ser Gly Pro Gly Leu Pro Pro Pro 
        195                 200                 205             


Pro Pro Pro Leu Pro Pro Pro Gly Pro Pro Pro Leu Phe Glu Asn Glu 
    210                 215                 220                 


Gly Lys Lys Glu Glu Ser Ser Pro Ser Arg Ser Ala Leu Phe Ala Gln 
225                 230                 235                 240 


Leu Asn Gln Gly Glu Ala Ile Xaa Lys Gly Leu Arg His Val Xaa Asp 
                245                 250                 255     


Asp Gln Lys Xaa Tyr Lys Asn Pro Ser Leu Arg Ala Gln Gly Gly Gln 
            260                 265                 270         


Xaa Gln Ser Pro Xaa Lys Ser His Xaa Pro Ser Pro Xaa Ser Pro Lys 
        275                 280                 285             


Ser Tyr Pro Ser Gln Lys His Ala Pro Val Leu Glu Leu Glu Gly Lys 
    290                 295                 300                 


Lys Trp Arg Val Glu Tyr Gln Glu Asp Arg Asn Asp Leu Val Ile Ser 
305                 310                 315                 320 


Glu Xaa Glu Leu Lys Gln Val Ala Tyr Ile Phe Lys Cys Glu Lys Ser 
                325                 330                 335     


Xaa Ile Gln Ile Lys Gly Lys Val Asn Ser Ile Ile Ile Asp Asn Cys 
            340                 345                 350         


Lys Lys Leu Gly Leu Val Phe Asp Asn Val Val Gly Ile Val Glu Val 
        355                 360                 365             


Ile Asn Ser Gln Asp Ile Gln Ile Gln Val Met Gly Arg Val Pro Xaa 
    370                 375                 380                 


Ile Ser Ile Asn Lys Xaa Glu Gly Cys His Ile Tyr Leu Ser Glu Asp 
385                 390                 395                 400 


Ala Leu Asp Cys Glu Ile Val Ser Ala Lys Ser Ser Glu Met Asn Ile 
                405                 410                 415     


Leu Ile Pro Gln Asp Gly Asp Tyr Arg Glu Phe Pro Ile Pro Glu Gln 
            420                 425                 430         


Phe Lys Xaa Ala Trp Asp Gly Ser Lys Leu Ile Xaa Glu Pro Ala Glu 
        435                 440                 445             


Ile Met Ala 
    450     


<210> 4912
<211> 194
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<400> 4912
Met Ala Asn Met Gln Gly Leu Val Glu Arg Leu Glu Arg Ala Val Ser 
1               5                   10                  15      


Arg Leu Glu Ser Leu Ser Ala Glu Ser His Arg Pro Pro Gly Asn Cys 
            20                  25                  30          


Gly Glu Val Asn Gly Val Ile Ala Gly Val Ala Pro Ser Val Glu Ala 
        35                  40                  45              


Phe Asp Lys Leu Met Asp Ser Met Val Ala Glu Phe Leu Lys Asn Ser 
    50                  55                  60                  


Arg Ile Leu Ala Gly Asp Val Glu Xaa His Asn Asp Val Ala Ala Leu 
65                  70                  75                  80  


Leu Lys Pro Ile Ser Glu Lys Ile Gln Glu Ile Gln Xaa Phe Arg Glu 
                85                  90                  95      


Arg Asn Arg Gly Ser Asn Met Phe Asn His Leu Ser Ala Val Ser Glu 
            100                 105                 110         


Ser Ile Pro Ala Leu Gly Trp Ile Ala Val Ser Pro Lys Pro Gly Pro 
        115                 120                 125             


Tyr Val Lys Glu Met Asn Asp Ala Ala Xaa Phe Tyr Xaa Asn Arg Val 
    130                 135                 140                 


Leu Lys Asp Tyr Lys His Ser Asp Leu Arg His Val Asp Trp Val Lys 
145                 150                 155                 160 


Ser Tyr Leu Asn Ile Trp Ser Glu Leu Gln Ala Tyr Ile Lys Glu His 
                165                 170                 175     


His Xaa Xaa Gly Leu Xaa Trp Ser Lys Xaa Asn Glu Lys Arg Arg Arg 
            180                 185                 190         


Gln Arg 
        


<210> 4913
<211> 185
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<400> 4913
Met Ala Xaa Val Gly Glu Trp Ser Cys Val Arg Cys Xaa Phe Leu Asn 
1               5                   10                  15      


Pro Ala Gly Gln Arg Gln Cys Ser Ile Cys Glu Ala Pro Arg His Lys 
            20                  25                  30          


Pro Asp Leu Asn His Ile Leu Arg Leu Ser Val Glu Glu Gln Lys Trp 
        35                  40                  45              


Pro Cys Ala Arg Cys Xaa Phe Arg Asn Phe Leu Gly Lys Glu Ala Cys 
    50                  55                  60                  


Glu Val Cys Gly Phe Xaa Pro Glu Pro Ala Pro Gly Ala Ala Phe Leu 
65                  70                  75                  80  


Pro Val Leu Asn Gly Val Leu Pro Lys Pro Pro Ala Ile Leu Gly Glu 
                85                  90                  95      


Pro Lys Gly Ser Cys Gln Glu Glu Ala Gly Pro Val Arg Xaa Ala Gly 
            100                 105                 110         


Leu Val Ala Xaa Glu Pro Ala Arg Gly Gln Cys Glu Asp Lys Asp Glu 
        115                 120                 125             


Glu Glu Lys Glu Glu Gln Glu Glu Glu Glu Gly Ala Ala Glu Pro Arg 
    130                 135                 140                 


Gly Gly Trp Ala Cys Pro Arg Cys Xaa Leu His Asn Xaa Pro Val Ala 
145                 150                 155                 160 


Ser Ser Cys Ser Val Cys Gly Gly Pro Arg Arg Leu Ser Leu Pro Arg 
                165                 170                 175     


Ile Pro Pro Glu Ala Leu Val Val Pro 
            180                 185 


<210> 4914
<211> 1086
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<400> 4914
Met Ala Xaa Val Gly Glu Trp Ser Cys Val Arg Cys Xaa Phe Leu Asn 
1               5                   10                  15      


Pro Ala Gly Gln Arg Gln Cys Ser Ile Cys Glu Ala Pro Arg His Lys 
            20                  25                  30          


Pro Asp Leu Asn His Ile Leu Arg Leu Ser Val Glu Glu Gln Lys Trp 
        35                  40                  45              


Pro Cys Ala Arg Cys Xaa Phe Arg Asn Phe Leu Gly Lys Glu Ala Cys 
    50                  55                  60                  


Glu Val Cys Gly Phe Xaa Pro Glu Pro Ala Pro Gly Ala Ala Phe Leu 
65                  70                  75                  80  


Pro Val Leu Asn Gly Val Leu Pro Lys Pro Pro Ala Ile Leu Gly Glu 
                85                  90                  95      


Pro Lys Gly Ser Cys Gln Glu Glu Ala Gly Pro Val Arg Xaa Ala Gly 
            100                 105                 110         


Leu Val Ala Xaa Glu Pro Ala Arg Gly Gln Cys Glu Asp Lys Asp Glu 
        115                 120                 125             


Glu Glu Lys Glu Glu Gln Glu Glu Glu Glu Gly Ala Ala Glu Pro Arg 
    130                 135                 140                 


Gly Gly Trp Ala Cys Pro Arg Cys Xaa Leu His Asn Xaa Pro Val Ala 
145                 150                 155                 160 


Ser Ser Cys Ser Val Cys Gly Gly Pro Arg Arg Leu Ser Leu Pro Arg 
                165                 170                 175     


Ile Pro Pro Glu Ala Leu Val Val Pro Glu Val Val Ala Pro Ala Gly 
            180                 185                 190         


Phe His Val Val Pro Ala Ala Pro Pro Pro Gly Leu Pro Gly Glu Gly 
        195                 200                 205             


Ala Glu Ala Asn Pro Pro Ala Xaa Ser Gln Gly Pro Ala Ala Glu Pro 
    210                 215                 220                 


Glu Pro Pro Arg Val Pro Pro Phe Ser Pro Phe Ser Ser Xaa Leu Gln 
225                 230                 235                 240 


Asn Asn Pro Val Pro Arg Ser Arg Arg Glu Val Pro Pro Gln Leu Gln 
                245                 250                 255     


Pro Pro Val Pro Glu Ala Ala Gln Pro Ser Pro Ser Ala Gly Cys Arg 
            260                 265                 270         


Gly Ala Pro Gln Gly Ser Gly Trp Ala Gly Ala Ser Arg Leu Ala Glu 
        275                 280                 285             


Leu Leu Ser Gly Lys Arg Leu Ser Val Leu Glu Glu Glu Ala Xaa Glu 
    290                 295                 300                 


Gly Gly Xaa Ser Arg Val Glu Ala Gly Ser Ser Xaa Ser Gly Ser Asp 
305                 310                 315                 320 


Ile Ile Asp Leu Ala Gly Asp Xaa Val Arg Tyr Xaa Pro Ala Ser Pro 
                325                 330                 335     


Ser Ser Pro Asp Phe Xaa Xaa Trp Ser Cys Ala Lys Cys Xaa Leu Arg 
            340                 345                 350         


Asn Pro Xaa Val Ala Pro Arg Cys Ser Ala Cys Gly Cys Ser Lys Leu 
        355                 360                 365             


His Gly Phe Gln Glu His Gly Glu Pro Pro Xaa His Cys Pro Asp Cys 
    370                 375                 380                 


Gly Ala Asp Lys Pro Ser Pro Cys Gly Arg Ser Cys Gly Arg Val Ser 
385                 390                 395                 400 


Ser Ala Gln Lys Ala Ala Arg Val Leu Pro Glu Arg Pro Gly Gln Trp 
                405                 410                 415     


Ala Cys Pro Ala Cys Xaa Leu Leu Asn Ala Leu Arg Ala Lys His Cys 
            420                 425                 430         


Ala Ala Cys His Xaa Pro Gln Leu Leu Val Ala Gln Arg Arg Gly Ala 
        435                 440                 445             


Ala Pro Leu Arg Arg Arg Glu Ser Met His Val Glu Gln Arg Arg Gln 
    450                 455                 460                 


Xaa Asp Glu Gly Glu Ala Lys Ala Leu Trp Glu Asn Ile Val Ala Phe 
465                 470                 475                 480 


Cys Arg Glu Asn Asn Val Ser Phe Val Asp Asp Ser Phe Pro Pro Gly 
                485                 490                 495     


Pro Glu Ser Val Gly Phe Pro Ala Gly Asp Ser Val Gln Gln Arg Val 
            500                 505                 510         


Arg Gln Trp Leu Arg Pro Gln Glu Ile Asn Cys Ser Val Phe Arg Asp 
        515                 520                 525             


His Arg Ala Xaa Trp Ser Val Phe His Xaa Leu Arg Pro Ser Asp Ile 
    530                 535                 540                 


Leu Gln Gly Leu Leu Gly Asn Cys Trp Phe Leu Ser Ala Leu Ala Val 
545                 550                 555                 560 


Leu Ala Glu Arg Pro Asp Leu Val Glu Arg Val Met Val Xaa Arg Ser 
                565                 570                 575     


Leu Cys Ala Glu Gly Ala Tyr Gln Val Arg Leu Cys Lys Asp Gly Xaa 
            580                 585                 590         


Trp Xaa Xaa Val Leu Val Asp Asp Met Leu Pro Cys Asp Glu Ala Gly 
        595                 600                 605             


Cys Leu Leu Phe Ser Gln Ala Gln Arg Lys Gln Leu Trp Val Ala Leu 
    610                 615                 620                 


Ile Glu Lys Ala Leu Ala Lys Leu His Gly Ser Tyr Phe Ala Leu Gln 
625                 630                 635                 640 


Ala Gly Arg Ala Ile Glu Gly Leu Ala Xaa Leu Xaa Gly Ala Pro Cys 
                645                 650                 655     


Glu Ser Leu Ala Leu Gln Leu Ser Ser Xaa Asn Pro Arg Glu Glu Pro 
            660                 665                 670         


Val Asp Xaa Asp Leu Ile Trp Ala Lys Met Leu Ser Ser Lys Glu Ala 
        675                 680                 685             


Gly Phe Leu Met Gly Ala Ser Cys Gly Gly Gly Asn Met Lys Val Asp 
    690                 695                 700                 


Asp Ser Ala Tyr Glu Ser Leu Gly Leu Arg Pro Arg His Ala Tyr Ser 
705                 710                 715                 720 


Ile Leu Asp Val Arg Asp Val Gln Gly Xaa Arg Leu Leu Arg Leu Arg 
                725                 730                 735     


Asn Pro Trp Gly Arg Phe Ser Trp Asn Gly Ser Trp Ser Asp Glu Trp 
            740                 745                 750         


Pro His Trp Pro Gly His Leu Arg Gly Glu Leu Met Pro His Gly Ser 
        755                 760                 765             


Ser Glu Gly Val Phe Trp Met Glu Tyr Gly Asp Phe Val Arg Tyr Phe 
    770                 775                 780                 


Asp Ser Val Asp Ile Cys Lys Val His Ser Asp Trp Gln Glu Ala Arg 
785                 790                 795                 800 


Val Gln Gly Cys Phe Pro Ser Ser Ala Ser Ala Pro Val Gly Val Xaa 
                805                 810                 815     


Ala Leu Xaa Val Leu Glu Arg Ala Ser Leu Glu Phe Ala Leu Phe Gln 
            820                 825                 830         


Glu Gly Ser Arg Arg Ser Asp Ala Val Asp Ser His Leu Leu Asp Leu 
        835                 840                 845             


Cys Ile Leu Val Phe Arg Ala Xaa Phe Gly Ser Gly Gly His Leu Ser 
    850                 855                 860                 


Leu Gly Arg Leu Leu Ala His Ser Lys Arg Ala Val Lys Lys Phe Val 
865                 870                 875                 880 


Ser Cys Asp Val Met Leu Glu Pro Gly Glu Tyr Ala Val Val Cys Cys 
                885                 890                 895     


Ala Phe Asn His Trp Gly Pro Pro Leu Pro Gly Xaa Pro Ala Pro Gln 
            900                 905                 910         


Ala Ser Ser Pro Ser Ala Gly Val Pro Arg Ala Ser Pro Glu Pro Pro 
        915                 920                 925             


Gly His Val Leu Ala Val Tyr Ser Ser Arg Leu Val Met Val Glu Pro 
    930                 935                 940                 


Val Glu Ala Gln Pro Xaa Xaa Leu Ala Asp Ala Ile Ile Leu Leu Xaa 
945                 950                 955                 960 


Glu Ser Arg Gly Glu Arg His Glu Gly Arg Glu Gly Met Xaa Cys Tyr 
                965                 970                 975     


Tyr Leu Xaa His Gly Trp Ala Gly Leu Ile Val Val Val Glu Asn Arg 
            980                 985                 990         


His Pro Lys Ala Tyr Leu His Val  Gln Cys Asp Cys Xaa  Asp Ser Phe 
        995                 1000                 1005             


Asn Val  Val Ser Xaa Arg Gly  Ser Leu Arg Xaa Gln  Asp Ser Val 
    1010                 1015                 1020             


Pro Pro  Leu His Arg Gln Val  Leu Val Ile Leu Ser  Gln Leu Glu 
    1025                 1030                 1035             


Gly Asn  Ala Gly Phe Ser Ile  Xaa His Arg Leu Ala  His Arg Lys 
    1040                 1045                 1050             


Ala Ala  Gln Ala Phe Leu Ser  Asp Trp Xaa Ala Ser  Lys Gly Xaa 
    1055                 1060                 1065             


His Ser  Pro Pro Leu Xaa Pro  Glu Val Ala Gly Leu  His Gly Pro 
    1070                 1075                 1080             


Arg Pro  Leu 
    1085     


<210> 4915
<211> 112
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<400> 4915
Met Cys Gln Val His Ala Gln Lys Pro His Ser Gly Pro Gln Val Leu 
1               5                   10                  15      


Gly Leu Arg Leu Leu Gln Xaa Ala Arg Leu Pro Gly Ala Trp Arg Ala 
            20                  25                  30          


Pro His Pro Leu Pro Arg Leu Trp Gly Arg Gln Ala Gln Pro Leu Arg 
        35                  40                  45              


Gln Lys Leu Arg Xaa Gly Val Leu Gly Pro Glu Gly Arg Pro Arg Pro 
    50                  55                  60                  


Ala Arg Ala Pro Gly Pro Val Gly Leu Pro Cys Leu Tyr Pro Ala Gln 
65                  70                  75                  80  


Arg Xaa Ala Gly Gln Ala Leu Arg Arg Leu Pro His Ala Ser Ala Pro 
                85                  90                  95      


Gly Gly Pro Ala Ala Gly Gly Arg Ala Pro Glu Ala Gln Gly Glu His 
            100                 105                 110         


<210> 4916
<211> 466
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<400> 4916
Met Gly Ser Ser Ala Ser Ser Leu Ala Ala Glu Xaa Glu Ser Asp His 
1               5                   10                  15      


Ser Phe Pro Gly Gly Pro Pro Tyr Pro Gly Pro Pro Ala Ala Ala Gly 
            20                  25                  30          


Trp Cys Arg Ser Gly Pro Gly Gly Pro Val Trp Gly Gly Ala Leu Val 
        35                  40                  45              


Ser Arg Gln His Gln Pro Pro Arg Pro Arg Ala Arg Ser His Xaa His 
    50                  55                  60                  


Ser Pro Gly Ser Met Ala Xaa Val Gly Glu Trp Ser Cys Val Arg Cys 
65                  70                  75                  80  


Xaa Phe Leu Asn Pro Ala Gly Gln Arg Gln Cys Ser Ile Cys Glu Ala 
                85                  90                  95      


Pro Arg His Lys Pro Asp Leu Asn His Ile Leu Arg Leu Ser Val Glu 
            100                 105                 110         


Glu Gln Lys Trp Pro Cys Ala Arg Cys Xaa Phe Arg Asn Phe Leu Gly 
        115                 120                 125             


Lys Glu Ala Cys Glu Val Cys Gly Phe Xaa Pro Glu Pro Ala Pro Gly 
    130                 135                 140                 


Ala Ala Phe Leu Pro Val Leu Asn Gly Val Leu Pro Lys Pro Pro Ala 
145                 150                 155                 160 


Ile Leu Gly Glu Pro Lys Gly Ser Cys Gln Glu Glu Ala Gly Pro Val 
                165                 170                 175     


Arg Xaa Ala Gly Leu Val Ala Xaa Glu Pro Ala Arg Gly Gln Cys Glu 
            180                 185                 190         


Asp Lys Asp Glu Glu Glu Lys Glu Glu Gln Glu Glu Glu Glu Gly Ala 
        195                 200                 205             


Ala Glu Pro Arg Gly Gly Trp Ala Cys Pro Arg Cys Xaa Leu His Asn 
    210                 215                 220                 


Xaa Pro Val Ala Ser Ser Cys Ser Val Cys Gly Gly Pro Arg Arg Leu 
225                 230                 235                 240 


Ser Leu Pro Arg Ile Pro Pro Glu Ala Leu Val Val Pro Glu Val Val 
                245                 250                 255     


Ala Pro Ala Gly Phe His Val Val Pro Ala Ala Pro Pro Pro Gly Leu 
            260                 265                 270         


Pro Gly Glu Gly Ala Glu Ala Asn Pro Pro Ala Xaa Ser Gln Gly Pro 
        275                 280                 285             


Ala Ala Glu Pro Glu Pro Pro Arg Val Pro Pro Phe Ser Pro Phe Ser 
    290                 295                 300                 


Ser Xaa Leu Gln Asn Asn Pro Val Pro Arg Ser Arg Arg Glu Val Pro 
305                 310                 315                 320 


Pro Gln Leu Gln Pro Pro Val Pro Glu Ala Ala Gln Pro Ser Pro Ser 
                325                 330                 335     


Ala Gly Cys Arg Gly Ala Pro Gln Gly Ser Gly Trp Ala Gly Ala Ser 
            340                 345                 350         


Arg Leu Ala Glu Leu Leu Ser Gly Lys Arg Leu Ser Val Leu Glu Glu 
        355                 360                 365             


Glu Ala Xaa Glu Gly Gly Xaa Ser Arg Val Glu Ala Gly Ser Ser Xaa 
    370                 375                 380                 


Ser Gly Ser Asp Ile Ile Asp Leu Ala Gly Asp Xaa Val Arg Tyr Xaa 
385                 390                 395                 400 


Pro Ala Ser Pro Ser Ser Pro Asp Phe Xaa Xaa Trp Ser Cys Ala Lys 
                405                 410                 415     


Cys Xaa Leu Arg Asn Pro Xaa Val Ala Pro Arg Cys Ser Ala Cys Gly 
            420                 425                 430         


Cys Ser Lys Leu His Gly Phe Gln Glu His Gly Glu Pro Pro Xaa His 
        435                 440                 445             


Cys Pro Asp Cys Gly Ala Asp Lys Pro Ser Pro Cys Gly Arg Ser Cys 
    450                 455                 460                 


Gly Arg 
465     


<210> 4917
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<400> 4917
Xaa Gly Glu Arg His Glu Gly Arg Glu Gly Met Xaa Cys Tyr Tyr Leu 
1               5                   10                  15      


Xaa His Gly Trp Ala Gly Leu Ile Val Val Val Glu Asn Arg His Pro 
            20                  25                  30          


Lys Ala Tyr Leu His Val Gln Cys Asp Cys Xaa Asp Ser Phe Asn Val 
        35                  40                  45              


Val Ser Xaa Arg Gly Ser Leu Arg Xaa Gln Asp Ser Val Pro Pro Leu 
    50                  55                  60                  


His Ser Pro Val Pro Leu Pro 
65                  70      


<210> 4918
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<400> 4918
Lys Ile Phe Lys His Tyr Asp Xaa Asp Gln Ser Gly Xaa Ile Asn Ser 
1               5                   10                  15      


Tyr Glu Met Arg Asn Ala Val Asn Asp Ala Gly Phe His Leu Asn Asn 
            20                  25                  30          


Gln Leu Tyr Asp Ile Ile Xaa Met Arg Tyr Ala Asp Lys His Met Asn 
        35                  40                  45              


Ile Asp Phe Asp Ser Phe Ile Cys Cys Phe Val Arg Leu Glu Gly Met 
    50                  55                  60                  


Phe Arg Ala Phe His Ala Phe Asp Lys Asp Gly Asp Gly Ile Ile Lys 
65                  70                  75                  80  


Leu Asn Val Leu Glu Trp Leu Gln Leu Xaa Met Tyr Ala 
                85                  90              


<210> 4919
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<400> 4919
Lys Lys Xaa Lys Pro Ile Ile Phe Val Ser Asp Arg Ala Asn Ser Asn 
1               5                   10                  15      


Lys Glu Leu Gly Val Asp Gln Glu Ser Glu Glu Gly Lys Gly Lys Xaa 
            20                  25                  30          


Ser Pro Asp Lys Gln Lys Gln Ser Pro Gln Pro Gln Pro Gly Ser Ser 
        35                  40                  45              


Asp Gln Glu Ser Glu Glu Gln Gln Gln Phe Arg Asn Ile Phe Lys Gln 
    50                  55                  60                  


Ile Ala Gly Asp Asp Met Glu Ile Cys Ala Asp Glu Leu Lys Lys Val 
65                  70                  75                  80  


Leu Asn Xaa Val Val Asn Lys His Lys Asp Leu Lys Xaa His Gly Phe 
                85                  90                  95      


Xaa Leu Glu Ser Cys Arg Ser Met Ile Ala Leu Met Asp Pro 
            100                 105                 110 


<210> 4920
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<400> 4920
Met Glu Ile Cys Ala Asp Glu Leu Lys Lys Val Leu Asn Xaa Val Val 
1               5                   10                  15      


Asn Lys His Lys Asp Leu Lys Xaa His Gly Phe Xaa Leu Glu Ser Cys 
            20                  25                  30          


Arg Ser Met Ile Ala Leu Met Asp Xaa Asp Gly Ser Gly Lys Leu Asn 
        35                  40                  45              


Leu Gln Glu Phe His His Leu Trp Asn Lys Ile Lys Ala Trp Gln Lys 
    50                  55                  60                  


Ile Phe Lys His Tyr Asp Xaa Asp Gln Ser Gly Xaa Ile Asn Ser Tyr 
65                  70                  75                  80  


Glu Met Arg Asn Ala Val Asn Asp Ala Gly Phe His Leu Asn Asn Gln 
                85                  90                  95      


Leu Tyr Asp Ile Ile Xaa Met Arg Tyr Ala Asp Lys His Met Asn Ile 
            100                 105                 110         


Asp Phe Asp Ser Phe Ile Cys Cys Phe Val Arg Leu Glu Gly Met Phe 
        115                 120                 125             


Arg Ala Phe His Ala Phe Asp Lys Asp Gly Asp Gly Ile Ile Lys Leu 
    130                 135                 140                 


Asn Val Leu Glu Ala Val Cys Arg Ser Xaa Cys Arg Trp His Ser Ala 
145                 150                 155                 160 


Pro Pro Cys Ala Arg Ala Leu His His Leu His Ala Val Pro Pro Trp 
                165                 170                 175     


Ala Arg Asn Gln Xaa Ser Xaa Gly Phe Tyr Cys Cys Gly Val Asn 
            180                 185                 190     


<210> 4921
<211> 156
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<400> 4921
Met Glu Ile Cys Ala Asp Glu Leu Lys Lys Val Leu Asn Xaa Val Val 
1               5                   10                  15      


Asn Lys His Lys Asp Leu Lys Xaa His Gly Phe Xaa Leu Glu Ser Cys 
            20                  25                  30          


Arg Ser Met Ile Ala Leu Met Asp Xaa Asp Gly Ser Gly Lys Leu Asn 
        35                  40                  45              


Leu Gln Glu Phe His His Leu Trp Asn Lys Ile Lys Ala Trp Gln Lys 
    50                  55                  60                  


Ile Phe Lys His Tyr Asp Xaa Asp Gln Ser Gly Xaa Ile Asn Ser Tyr 
65                  70                  75                  80  


Glu Met Arg Asn Ala Val Asn Asp Ala Gly Phe His Leu Asn Asn Gln 
                85                  90                  95      


Leu Tyr Asp Ile Ile Xaa Met Arg Tyr Ala Asp Lys His Met Asn Ile 
            100                 105                 110         


Asp Phe Asp Ser Phe Ile Cys Cys Phe Val Arg Leu Glu Gly Met Phe 
        115                 120                 125             


Arg Ala Phe His Ala Phe Asp Lys Asp Gly Asp Gly Ile Ile Lys Leu 
    130                 135                 140                 


Asn Val Leu Glu Trp Leu Gln Leu Xaa Met Tyr Ala 
145                 150                 155     


<210> 4922
<211> 157
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<400> 4922
Met Gly Gly Val Ala Ser Xaa Leu Gln Gly Leu Pro Met Arg Leu Gly 
1               5                   10                  15      


Tyr Xaa Gly Ala Gly Gly Phe Pro Gly Val Cys Leu Glu His Leu Glu 
            20                  25                  30          


Pro Gln Pro Gly Ser Ser Asp Gln Glu Ser Glu Glu Gln Gln Gln Phe 
        35                  40                  45              


Arg Asn Ile Phe Lys Gln Ile Ala Gly Asp Asp Met Glu Ile Cys Ala 
    50                  55                  60                  


Asp Glu Leu Lys Lys Val Leu Asn Xaa Val Val Asn Lys His Lys Asp 
65                  70                  75                  80  


Leu Lys Xaa His Gly Phe Xaa Leu Glu Ser Cys Arg Ser Met Ile Ala 
                85                  90                  95      


Leu Met Asp Xaa Asp Gly Ser Gly Lys Leu Asn Leu Gln Glu Phe His 
            100                 105                 110         


His Leu Trp Asn Lys Ile Lys Ala Trp Gln Lys Ile Phe Lys His Tyr 
        115                 120                 125             


Asp Xaa Asp Gln Ser Gly Xaa Ile Asn Ser Tyr Glu Met Arg Asn Ala 
    130                 135                 140                 


Val Asn Asp Ala Gly Phe His Leu Asn Asn Gln Leu Tyr 
145                 150                 155         


<210> 4923
<211> 309
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<400> 4923
Met His Gly Asn Lys Gln His Leu Gln Lys Asp Phe Phe Leu Tyr Asn 
1               5                   10                  15      


Ala Ser Lys Ala Arg Ser Lys Xaa Tyr Ile Asn Met Arg Glu Val Ser 
            20                  25                  30          


Gln Arg Phe Arg Leu Pro Pro Ser Glu Tyr Val Ile Val Pro Ser Xaa 
        35                  40                  45              


Tyr Glu Pro His Gln Glu Gly Glu Phe Ile Leu Arg Val Phe Ser Glu 
    50                  55                  60                  


Lys Arg Asn Leu Ser Glu Glu Val Glu Asn Xaa Ile Ser Val Asp Arg 
65                  70                  75                  80  


Pro Val Lys Lys Lys Lys Xaa Lys Pro Ile Ile Phe Val Ser Asp Arg 
                85                  90                  95      


Ala Asn Ser Asn Lys Glu Leu Gly Val Asp Gln Glu Ser Glu Glu Gly 
            100                 105                 110         


Lys Gly Lys Xaa Ser Pro Asp Lys Gln Lys Gln Ser Pro Gln Pro Gln 
        115                 120                 125             


Pro Gly Ser Ser Asp Gln Glu Ser Glu Glu Gln Gln Gln Phe Arg Asn 
    130                 135                 140                 


Ile Phe Lys Gln Ile Ala Gly Asp Asp Met Glu Ile Cys Ala Asp Glu 
145                 150                 155                 160 


Leu Lys Lys Val Leu Asn Xaa Val Val Asn Lys His Lys Asp Leu Lys 
                165                 170                 175     


Xaa His Gly Phe Xaa Leu Glu Ser Cys Arg Ser Met Ile Ala Leu Met 
            180                 185                 190         


Asp Xaa Asp Gly Ser Gly Lys Leu Asn Leu Gln Glu Phe His His Leu 
        195                 200                 205             


Trp Asn Lys Ile Lys Ala Trp Gln Lys Ile Phe Lys His Tyr Asp Xaa 
    210                 215                 220                 


Asp Gln Ser Gly Xaa Ile Asn Ser Tyr Glu Met Arg Asn Ala Val Asn 
225                 230                 235                 240 


Asp Ala Gly Phe His Leu Asn Asn Gln Leu Tyr Asp Ile Ile Xaa Met 
                245                 250                 255     


Arg Tyr Ala Asp Lys His Met Asn Ile Asp Phe Asp Ser Phe Ile Cys 
            260                 265                 270         


Cys Phe Val Arg Leu Glu Gly Met Phe Arg Ala Phe His Ala Phe Asp 
        275                 280                 285             


Lys Asp Gly Asp Gly Ile Ile Lys Leu Asn Val Leu Glu Trp Leu Gln 
    290                 295                 300                 


Leu Xaa Met Tyr Ala 
305                 


<210> 4924
<211> 256
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<400> 4924
Met His Gly Asn Lys Gln His Leu Gln Lys Asp Phe Phe Leu Tyr Asn 
1               5                   10                  15      


Ala Ser Lys Ala Arg Ser Lys Xaa Tyr Ile Asn Met Arg Glu Val Ser 
            20                  25                  30          


Gln Arg Phe Arg Leu Pro Pro Ser Glu Tyr Val Ile Val Pro Ser Xaa 
        35                  40                  45              


Tyr Glu Pro His Gln Glu Gly Glu Phe Ile Leu Arg Val Phe Ser Glu 
    50                  55                  60                  


Lys Arg Asn Leu Ser Glu Glu Val Glu Asn Xaa Ile Ser Val Asp Arg 
65                  70                  75                  80  


Pro Val Pro Gln Pro Gly Ser Ser Asp Gln Glu Ser Glu Glu Gln Gln 
                85                  90                  95      


Gln Phe Arg Asn Ile Phe Lys Gln Ile Ala Gly Asp Asp Met Glu Ile 
            100                 105                 110         


Cys Ala Asp Glu Leu Lys Lys Val Leu Asn Xaa Val Val Asn Lys His 
        115                 120                 125             


Lys Asp Leu Lys Xaa His Gly Phe Xaa Leu Glu Ser Cys Arg Ser Met 
    130                 135                 140                 


Ile Ala Leu Met Asp Xaa Asp Gly Ser Gly Lys Leu Asn Leu Gln Glu 
145                 150                 155                 160 


Phe His His Leu Trp Asn Lys Ile Lys Ala Trp Gln Lys Ile Phe Lys 
                165                 170                 175     


His Tyr Asp Xaa Asp Gln Ser Gly Xaa Ile Asn Ser Tyr Glu Met Arg 
            180                 185                 190         


Asn Ala Val Asn Asp Ala Gly Phe His Leu Asn Asn Gln Leu Tyr Asp 
        195                 200                 205             


Ile Ile Xaa Met Arg Tyr Ala Asp Lys His Met Asn Ile Asp Phe Asp 
    210                 215                 220                 


Ser Phe Ile Cys Cys Phe Val Arg Leu Glu Gly Met Phe Arg Ala Phe 
225                 230                 235                 240 


His Ala Phe Asp Lys Asp Gly Asp Gly Ile Ile Lys Leu Asn Val Leu 
                245                 250                 255     


<210> 4925
<211> 729
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<400> 4925
Met Pro Xaa Val Ile Ser Ala Ser Val Ala Pro Arg Xaa Ala Ala Glu 
1               5                   10                  15      


Pro Arg Ser Pro Gly Pro Val Pro His Pro Ala Gln Ser Lys Ala Xaa 
            20                  25                  30          


Glu Ala Gly Gly Gly Asn Pro Ser Gly Ile Tyr Ser Ala Ile Ile Ser 
        35                  40                  45              


Arg Asn Phe Pro Ile Ile Gly Val Lys Glu Lys Xaa Phe Glu Gln Leu 
    50                  55                  60                  


His Lys Lys Cys Leu Glu Lys Lys Val Leu Tyr Val Asp Pro Glu Phe 
65                  70                  75                  80  


Pro Pro Asp Glu Xaa Ser Leu Phe Tyr Ser Gln Lys Phe Pro Ile Gln 
                85                  90                  95      


Phe Val Trp Lys Arg Pro Pro Glu Ile Cys Glu Asn Pro Arg Phe Ile 
            100                 105                 110         


Ile Asp Gly Ala Asn Arg Xaa Asp Ile Cys Gln Gly Glu Leu Gly Asp 
        115                 120                 125             


Cys Trp Phe Leu Ala Ala Ile Ala Cys Leu Xaa Leu Asn Gln His Leu 
    130                 135                 140                 


Leu Phe Arg Val Ile Pro His Asp Gln Ser Phe Ile Glu Asn Tyr Ala 
145                 150                 155                 160 


Gly Ile Phe His Phe Gln Phe Trp Arg Tyr Gly Glu Trp Val Asp Val 
                165                 170                 175     


Val Ile Asp Asp Cys Leu Pro Xaa Tyr Asn Asn Gln Leu Val Phe Xaa 
            180                 185                 190         


Lys Ser Asn His Arg Asn Glu Phe Trp Ser Ala Leu Leu Glu Lys Ala 
        195                 200                 205             


Tyr Ala Lys Leu His Gly Ser Tyr Glu Ala Leu Lys Gly Gly Asn Xaa 
    210                 215                 220                 


Xaa Glu Ala Met Glu Asp Phe Xaa Gly Gly Val Ala Glu Phe Phe Glu 
225                 230                 235                 240 


Ile Arg Asp Ala Pro Ser Asp Met Tyr Lys Ile Met Lys Lys Ala Ile 
                245                 250                 255     


Glu Arg Gly Ser Leu Met Gly Cys Ser Ile Asp Xaa Ile Ile Pro Val 
            260                 265                 270         


Gln Tyr Glu Xaa Arg Met Ala Cys Gly Leu Val Arg Gly His Ala Tyr 
        275                 280                 285             


Ser Val Xaa Gly Leu Asp Glu Val Pro Phe Lys Gly Glu Lys Val Lys 
    290                 295                 300                 


Leu Val Arg Leu Arg Asn Pro Trp Gly Gln Val Glu Trp Asn Gly Ser 
305                 310                 315                 320 


Trp Ser Asp Arg Trp Lys Asp Trp Ser Phe Val Asp Lys Asp Glu Lys 
                325                 330                 335     


Ala Arg Leu Gln His Gln Val Xaa Glu Asp Gly Glu Phe Trp Met Ser 
            340                 345                 350         


Tyr Glu Asp Phe Ile Tyr His Phe Xaa Lys Leu Glu Ile Cys Asn Leu 
        355                 360                 365             


Xaa Ala Asp Ala Leu Gln Ser Asp Lys Leu Gln Xaa Trp Xaa Val Ser 
    370                 375                 380                 


Val Asn Glu Gly Arg Trp Val Arg Gly Cys Ser Ala Gly Gly Cys Arg 
385                 390                 395                 400 


Asn Phe Pro Asp Xaa Phe Trp Xaa Asn Pro Gln Tyr Arg Leu Lys Leu 
                405                 410                 415     


Leu Glu Glu Asp Asp Asp Pro Asp Asp Ser Glu Val Ile Cys Ser Phe 
            420                 425                 430         


Leu Val Ala Leu Met Gln Lys Asn Arg Arg Lys Asp Arg Lys Leu Gly 
        435                 440                 445             


Ala Ser Leu Phe Xaa Ile Gly Phe Ala Ile Tyr Glu Val Pro Lys Glu 
    450                 455                 460                 


Met His Gly Asn Lys Gln His Leu Gln Lys Asp Phe Phe Leu Tyr Asn 
465                 470                 475                 480 


Ala Ser Lys Ala Arg Ser Lys Xaa Tyr Ile Asn Met Arg Glu Val Ser 
                485                 490                 495     


Gln Arg Phe Arg Leu Pro Pro Ser Glu Tyr Val Ile Val Pro Ser Xaa 
            500                 505                 510         


Tyr Glu Pro His Gln Glu Gly Glu Phe Ile Leu Arg Val Phe Ser Glu 
        515                 520                 525             


Lys Arg Asn Leu Ser Glu Glu Val Glu Asn Xaa Ile Ser Val Asp Arg 
    530                 535                 540                 


Pro Val Pro Gln Pro Gly Ser Ser Asp Gln Glu Ser Glu Glu Gln Gln 
545                 550                 555                 560 


Gln Phe Arg Asn Ile Phe Lys Gln Ile Ala Gly Asp Asp Met Glu Ile 
                565                 570                 575     


Cys Ala Asp Glu Leu Lys Lys Val Leu Asn Xaa Val Val Asn Lys His 
            580                 585                 590         


Lys Asp Leu Lys Xaa His Gly Phe Xaa Leu Glu Ser Cys Arg Ser Met 
        595                 600                 605             


Ile Ala Leu Met Asp Xaa Asp Gly Ser Gly Lys Leu Asn Leu Gln Glu 
    610                 615                 620                 


Phe His His Leu Trp Asn Lys Ile Lys Ala Trp Gln Lys Ile Phe Lys 
625                 630                 635                 640 


His Tyr Asp Xaa Asp Gln Ser Gly Xaa Ile Asn Ser Tyr Glu Met Arg 
                645                 650                 655     


Asn Ala Val Asn Asp Ala Gly Phe His Leu Asn Asn Gln Leu Tyr Asp 
            660                 665                 670         


Ile Ile Xaa Met Arg Tyr Ala Asp Lys His Met Asn Ile Asp Phe Asp 
        675                 680                 685             


Ser Phe Ile Cys Cys Phe Val Arg Leu Glu Gly Met Phe Arg Ala Phe 
    690                 695                 700                 


His Ala Phe Asp Lys Asp Gly Asp Gly Ile Ile Lys Leu Asn Val Leu 
705                 710                 715                 720 


Glu Trp Leu Gln Leu Xaa Met Tyr Ala 
                725                 


<210> 4926
<211> 773
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<400> 4926
Met Pro Xaa Val Ile Ser Ala Ser Val Ala Pro Arg Xaa Ala Ala Glu 
1               5                   10                  15      


Pro Arg Ser Pro Gly Pro Val Pro His Pro Ala Gln Ser Lys Ala Xaa 
            20                  25                  30          


Glu Ala Gly Gly Gly Asn Pro Ser Gly Ile Tyr Ser Ala Ile Ile Ser 
        35                  40                  45              


Arg Asn Phe Pro Ile Ile Gly Val Lys Glu Lys Xaa Phe Glu Gln Leu 
    50                  55                  60                  


His Lys Lys Cys Leu Glu Lys Lys Val Leu Tyr Val Asp Pro Glu Phe 
65                  70                  75                  80  


Pro Pro Asp Glu Xaa Ser Leu Phe Tyr Ser Gln Lys Phe Pro Ile Gln 
                85                  90                  95      


Phe Val Trp Lys Arg Pro Pro Glu Ile Cys Glu Asn Pro Arg Phe Ile 
            100                 105                 110         


Ile Asp Gly Ala Asn Arg Xaa Asp Ile Cys Gln Gly Glu Leu Gly Asp 
        115                 120                 125             


Cys Trp Phe Leu Ala Ala Ile Ala Cys Leu Xaa Leu Asn Gln His Leu 
    130                 135                 140                 


Leu Phe Arg Val Ile Pro His Asp Gln Ser Phe Ile Glu Asn Tyr Ala 
145                 150                 155                 160 


Gly Ile Phe His Phe Gln Phe Trp Arg Tyr Gly Glu Trp Val Asp Val 
                165                 170                 175     


Val Ile Asp Asp Cys Leu Pro Xaa Tyr Asn Asn Gln Leu Val Phe Xaa 
            180                 185                 190         


Lys Ser Asn His Arg Asn Glu Phe Trp Ser Ala Leu Leu Glu Lys Ala 
        195                 200                 205             


Tyr Ala Lys Leu His Gly Ser Tyr Glu Ala Leu Lys Gly Gly Asn Xaa 
    210                 215                 220                 


Xaa Glu Ala Met Glu Asp Phe Xaa Gly Gly Val Ala Glu Phe Phe Glu 
225                 230                 235                 240 


Ile Arg Asp Ala Pro Ser Asp Met Tyr Lys Ile Met Lys Lys Ala Ile 
                245                 250                 255     


Glu Arg Gly Ser Leu Met Gly Cys Ser Ile Asp Xaa Ile Ile Pro Val 
            260                 265                 270         


Gln Tyr Glu Xaa Arg Met Ala Cys Gly Leu Val Arg Gly His Ala Tyr 
        275                 280                 285             


Ser Val Xaa Gly Leu Asp Glu Val Pro Phe Lys Gly Glu Lys Val Lys 
    290                 295                 300                 


Leu Val Arg Leu Arg Asn Pro Trp Gly Gln Val Glu Trp Asn Gly Ser 
305                 310                 315                 320 


Trp Ser Asp Arg Trp Lys Asp Trp Ser Phe Val Asp Lys Asp Glu Lys 
                325                 330                 335     


Ala Arg Leu Gln His Gln Val Xaa Glu Asp Gly Glu Phe Trp Met Ser 
            340                 345                 350         


Tyr Glu Asp Phe Ile Tyr His Phe Xaa Lys Leu Glu Ile Cys Asn Leu 
        355                 360                 365             


Xaa Ala Asp Ala Leu Gln Ser Asp Lys Leu Gln Xaa Trp Xaa Val Ser 
    370                 375                 380                 


Val Asn Glu Gly Arg Trp Val Arg Gly Cys Ser Ala Gly Gly Cys Arg 
385                 390                 395                 400 


Asn Phe Pro Asp Xaa Phe Trp Xaa Asn Pro Gln Tyr Arg Leu Lys Leu 
                405                 410                 415     


Leu Glu Glu Asp Asp Asp Pro Asp Asp Ser Glu Val Ile Cys Ser Phe 
            420                 425                 430         


Leu Val Ala Leu Met Gln Lys Asn Arg Arg Lys Asp Arg Lys Leu Gly 
        435                 440                 445             


Ala Ser Leu Phe Xaa Ile Gly Phe Ala Ile Tyr Glu Val Pro Lys Glu 
    450                 455                 460                 


Met His Gly Asn Lys Gln His Leu Gln Lys Asp Phe Phe Leu Tyr Asn 
465                 470                 475                 480 


Ala Ser Lys Ala Arg Ser Lys Xaa Tyr Ile Asn Met Arg Glu Val Ser 
                485                 490                 495     


Gln Arg Phe Arg Leu Pro Pro Ser Glu Tyr Val Ile Val Pro Ser Xaa 
            500                 505                 510         


Tyr Glu Pro His Gln Glu Gly Glu Phe Ile Leu Arg Val Phe Ser Glu 
        515                 520                 525             


Lys Arg Asn Leu Ser Glu Glu Val Glu Asn Xaa Ile Ser Val Asp Arg 
    530                 535                 540                 


Pro Val Lys Lys Lys Lys Xaa Lys Pro Ile Ile Phe Val Ser Asp Arg 
545                 550                 555                 560 


Ala Asn Ser Asn Lys Glu Leu Gly Val Asp Gln Glu Ser Glu Glu Gly 
                565                 570                 575     


Lys Gly Lys Xaa Ser Pro Asp Lys Gln Lys Gln Ser Pro Gln Pro Gln 
            580                 585                 590         


Pro Gly Ser Ser Asp Gln Glu Ser Glu Glu Gln Gln Gln Phe Arg Asn 
        595                 600                 605             


Ile Phe Lys Gln Ile Ala Gly Asp Asp Met Glu Ile Cys Ala Asp Glu 
    610                 615                 620                 


Leu Lys Lys Val Leu Asn Xaa Val Val Asn Lys His Lys Asp Leu Lys 
625                 630                 635                 640 


Xaa His Gly Phe Xaa Leu Glu Ser Cys Arg Ser Met Ile Ala Leu Met 
                645                 650                 655     


Asp Xaa Asp Gly Ser Gly Lys Leu Asn Leu Gln Glu Phe His His Leu 
            660                 665                 670         


Trp Asn Lys Ile Lys Ala Trp Gln Lys Ile Phe Lys His Tyr Asp Xaa 
        675                 680                 685             


Asp Gln Ser Gly Xaa Ile Asn Ser Tyr Glu Met Arg Asn Ala Val Asn 
    690                 695                 700                 


Asp Ala Gly Phe His Leu Asn Asn Gln Leu Tyr Asp Ile Ile Xaa Met 
705                 710                 715                 720 


Arg Tyr Ala Asp Lys His Met Asn Ile Asp Phe Asp Ser Phe Ile Cys 
                725                 730                 735     


Cys Phe Val Arg Leu Glu Gly Met Phe Arg Ala Phe His Ala Phe Asp 
            740                 745                 750         


Lys Asp Gly Asp Gly Ile Ile Lys Leu Asn Val Leu Glu Trp Leu Gln 
        755                 760                 765             


Leu Xaa Met Tyr Ala 
    770             


<210> 4927
<211> 815
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<400> 4927
Met Pro Xaa Val Ile Ser Ala Ser Val Ala Pro Arg Xaa Ala Ala Glu 
1               5                   10                  15      


Pro Arg Ser Pro Gly Pro Val Pro His Pro Ala Gln Ser Lys Ala Xaa 
            20                  25                  30          


Glu Ala Gly Gly Gly Asn Pro Ser Gly Ile Tyr Ser Ala Ile Ile Ser 
        35                  40                  45              


Arg Asn Phe Pro Ile Ile Gly Val Lys Glu Lys Xaa Phe Glu Gln Leu 
    50                  55                  60                  


His Lys Lys Cys Leu Glu Lys Lys Val Leu Tyr Val Asp Pro Glu Phe 
65                  70                  75                  80  


Pro Pro Asp Glu Xaa Ser Leu Phe Tyr Ser Gln Lys Phe Pro Ile Gln 
                85                  90                  95      


Phe Val Trp Lys Arg Pro Pro Glu Ile Cys Glu Asn Pro Arg Phe Ile 
            100                 105                 110         


Ile Asp Gly Ala Asn Arg Xaa Asp Ile Cys Gln Gly Glu Leu Gly Asp 
        115                 120                 125             


Cys Trp Phe Leu Ala Ala Ile Ala Cys Leu Xaa Leu Asn Gln His Leu 
    130                 135                 140                 


Leu Phe Arg Val Ile Pro His Asp Gln Ser Phe Ile Glu Asn Tyr Ala 
145                 150                 155                 160 


Gly Ile Phe His Phe Gln Phe Trp Arg Tyr Gly Glu Trp Val Asp Val 
                165                 170                 175     


Val Ile Asp Asp Cys Leu Pro Xaa Tyr Asn Asn Gln Leu Val Phe Xaa 
            180                 185                 190         


Lys Ser Asn His Arg Asn Glu Phe Trp Ser Ala Leu Leu Glu Lys Ala 
        195                 200                 205             


Tyr Ala Lys Leu His Gly Ser Tyr Glu Ala Leu Lys Gly Gly Asn Xaa 
    210                 215                 220                 


Xaa Glu Ala Met Glu Asp Phe Xaa Gly Gly Val Ala Glu Phe Phe Glu 
225                 230                 235                 240 


Ile Arg Asp Ala Pro Ser Asp Met Tyr Lys Ile Met Lys Lys Ala Ile 
                245                 250                 255     


Glu Arg Gly Ser Leu Met Gly Cys Ser Ile Asp Asp Gly Xaa Asn Met 
            260                 265                 270         


Xaa Tyr Gly Xaa Ser Pro Ser Gly Leu Asn Met Gly Glu Leu Ile Ala 
        275                 280                 285             


Arg Met Val Arg Asn Met Asp Asn Ser Leu Leu Gln Asp Ser Asp Leu 
    290                 295                 300                 


Asp Pro Arg Gly Ser Asp Glu Arg Pro Xaa Arg Xaa Ile Ile Pro Val 
305                 310                 315                 320 


Gln Tyr Glu Xaa Arg Met Ala Cys Gly Leu Val Arg Gly His Ala Tyr 
                325                 330                 335     


Ser Val Xaa Gly Leu Asp Glu Val Pro Phe Lys Gly Glu Lys Val Lys 
            340                 345                 350         


Leu Val Arg Leu Arg Asn Pro Trp Gly Gln Val Glu Trp Asn Gly Ser 
        355                 360                 365             


Trp Ser Asp Arg Trp Lys Asp Trp Ser Phe Val Asp Lys Asp Glu Lys 
    370                 375                 380                 


Ala Arg Leu Gln His Gln Val Xaa Glu Asp Gly Glu Phe Trp Met Ser 
385                 390                 395                 400 


Tyr Glu Asp Phe Ile Tyr His Phe Xaa Lys Leu Glu Ile Cys Asn Leu 
                405                 410                 415     


Xaa Ala Asp Ala Leu Gln Ser Asp Lys Leu Gln Xaa Trp Xaa Val Ser 
            420                 425                 430         


Val Asn Glu Gly Arg Trp Val Arg Gly Cys Ser Ala Gly Gly Cys Arg 
        435                 440                 445             


Asn Phe Pro Asp Xaa Phe Trp Xaa Asn Pro Gln Tyr Arg Leu Lys Leu 
    450                 455                 460                 


Leu Glu Glu Asp Asp Asp Pro Asp Asp Ser Glu Val Ile Cys Ser Phe 
465                 470                 475                 480 


Leu Val Ala Leu Met Gln Lys Asn Arg Arg Lys Asp Arg Lys Leu Gly 
                485                 490                 495     


Ala Ser Leu Phe Xaa Ile Gly Phe Ala Ile Tyr Glu Val Pro Lys Glu 
            500                 505                 510         


Met His Gly Asn Lys Gln His Leu Gln Lys Asp Phe Phe Leu Tyr Asn 
        515                 520                 525             


Ala Ser Lys Ala Arg Ser Lys Xaa Tyr Ile Asn Met Arg Glu Val Ser 
    530                 535                 540                 


Gln Arg Phe Arg Leu Pro Pro Ser Glu Tyr Val Ile Val Pro Ser Xaa 
545                 550                 555                 560 


Tyr Glu Pro His Gln Glu Gly Glu Phe Ile Leu Arg Val Phe Ser Glu 
                565                 570                 575     


Lys Arg Asn Leu Ser Glu Glu Val Glu Asn Xaa Ile Ser Val Asp Arg 
            580                 585                 590         


Pro Val Pro Ile Ile Phe Val Ser Asp Arg Ala Asn Ser Asn Lys Glu 
        595                 600                 605             


Leu Gly Val Asp Gln Glu Ser Glu Glu Gly Lys Gly Lys Xaa Ser Pro 
    610                 615                 620                 


Asp Lys Gln Lys Gln Ser Pro Gln Pro Gln Pro Gly Ser Ser Asp Gln 
625                 630                 635                 640 


Glu Ser Glu Glu Gln Gln Gln Phe Arg Asn Ile Phe Lys Gln Ile Ala 
                645                 650                 655     


Gly Asp Asp Met Glu Ile Cys Ala Asp Glu Leu Lys Lys Val Leu Asn 
            660                 665                 670         


Xaa Val Val Asn Lys His Lys Asp Leu Lys Xaa His Gly Phe Xaa Leu 
        675                 680                 685             


Glu Ser Cys Arg Ser Met Ile Ala Leu Met Asp Xaa Asp Gly Ser Gly 
    690                 695                 700                 


Lys Leu Asn Leu Gln Glu Phe His His Leu Trp Asn Lys Ile Lys Ala 
705                 710                 715                 720 


Trp Gln Lys Ile Phe Lys His Tyr Asp Xaa Asp Gln Ser Gly Xaa Ile 
                725                 730                 735     


Asn Ser Tyr Glu Met Arg Asn Ala Val Asn Asp Ala Gly Phe His Leu 
            740                 745                 750         


Asn Asn Gln Leu Tyr Asp Ile Ile Xaa Met Arg Tyr Ala Asp Lys His 
        755                 760                 765             


Met Asn Ile Asp Phe Asp Ser Phe Ile Cys Cys Phe Val Arg Leu Glu 
    770                 775                 780                 


Gly Met Phe Arg Ala Phe His Ala Phe Asp Lys Asp Gly Asp Gly Ile 
785                 790                 795                 800 


Ile Lys Leu Asn Val Leu Glu Trp Leu Gln Leu Xaa Met Tyr Ala 
                805                 810                 815 


<210> 4928
<211> 821
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<400> 4928
Met Pro Xaa Val Ile Ser Ala Ser Val Ala Pro Arg Xaa Ala Ala Glu 
1               5                   10                  15      


Pro Arg Ser Pro Gly Pro Val Pro His Pro Ala Gln Ser Lys Ala Xaa 
            20                  25                  30          


Glu Ala Gly Gly Gly Asn Pro Ser Gly Ile Tyr Ser Ala Ile Ile Ser 
        35                  40                  45              


Arg Asn Phe Pro Ile Ile Gly Val Lys Glu Lys Xaa Phe Glu Gln Leu 
    50                  55                  60                  


His Lys Lys Cys Leu Glu Lys Lys Val Leu Tyr Val Asp Pro Glu Phe 
65                  70                  75                  80  


Pro Pro Asp Glu Xaa Ser Leu Phe Tyr Ser Gln Lys Phe Pro Ile Gln 
                85                  90                  95      


Phe Val Trp Lys Arg Pro Pro Glu Ile Cys Glu Asn Pro Arg Phe Ile 
            100                 105                 110         


Ile Asp Gly Ala Asn Arg Xaa Asp Ile Cys Gln Gly Glu Leu Gly Asp 
        115                 120                 125             


Cys Trp Phe Leu Ala Ala Ile Ala Cys Leu Xaa Leu Asn Gln His Leu 
    130                 135                 140                 


Leu Phe Arg Val Ile Pro His Asp Gln Ser Phe Ile Glu Asn Tyr Ala 
145                 150                 155                 160 


Gly Ile Phe His Phe Gln Phe Trp Arg Tyr Gly Glu Trp Val Asp Val 
                165                 170                 175     


Val Ile Asp Asp Cys Leu Pro Xaa Tyr Asn Asn Gln Leu Val Phe Xaa 
            180                 185                 190         


Lys Ser Asn His Arg Asn Glu Phe Trp Ser Ala Leu Leu Glu Lys Ala 
        195                 200                 205             


Tyr Ala Lys Leu His Gly Ser Tyr Glu Ala Leu Lys Gly Gly Asn Xaa 
    210                 215                 220                 


Xaa Glu Ala Met Glu Asp Phe Xaa Gly Gly Val Ala Glu Phe Phe Glu 
225                 230                 235                 240 


Ile Arg Asp Ala Pro Ser Asp Met Tyr Lys Ile Met Lys Lys Ala Ile 
                245                 250                 255     


Glu Arg Gly Ser Leu Met Gly Cys Ser Ile Asp Asp Gly Xaa Asn Met 
            260                 265                 270         


Xaa Tyr Gly Xaa Ser Pro Ser Gly Leu Asn Met Gly Glu Leu Ile Ala 
        275                 280                 285             


Arg Met Val Arg Asn Met Asp Asn Ser Leu Leu Gln Asp Ser Asp Leu 
    290                 295                 300                 


Asp Pro Arg Gly Ser Asp Glu Arg Pro Xaa Arg Xaa Ile Ile Pro Val 
305                 310                 315                 320 


Gln Tyr Glu Xaa Arg Met Ala Cys Gly Leu Val Arg Gly His Ala Tyr 
                325                 330                 335     


Ser Val Xaa Gly Leu Asp Glu Val Pro Phe Lys Gly Glu Lys Val Lys 
            340                 345                 350         


Leu Val Arg Leu Arg Asn Pro Trp Gly Gln Val Glu Trp Asn Gly Ser 
        355                 360                 365             


Trp Ser Asp Arg Trp Lys Asp Trp Ser Phe Val Asp Lys Asp Glu Lys 
    370                 375                 380                 


Ala Arg Leu Gln His Gln Val Xaa Glu Asp Gly Glu Phe Trp Met Ser 
385                 390                 395                 400 


Tyr Glu Asp Phe Ile Tyr His Phe Xaa Lys Leu Glu Ile Cys Asn Leu 
                405                 410                 415     


Xaa Ala Asp Ala Leu Gln Ser Asp Lys Leu Gln Xaa Trp Xaa Val Ser 
            420                 425                 430         


Val Asn Glu Gly Arg Trp Val Arg Gly Cys Ser Ala Gly Gly Cys Arg 
        435                 440                 445             


Asn Phe Pro Asp Xaa Phe Trp Xaa Asn Pro Gln Tyr Arg Leu Lys Leu 
    450                 455                 460                 


Leu Glu Glu Asp Asp Asp Pro Asp Asp Ser Glu Val Ile Cys Ser Phe 
465                 470                 475                 480 


Leu Val Ala Leu Met Gln Lys Asn Arg Arg Lys Asp Arg Lys Leu Gly 
                485                 490                 495     


Ala Ser Leu Phe Xaa Ile Gly Phe Ala Ile Tyr Glu Val Pro Lys Glu 
            500                 505                 510         


Met His Gly Asn Lys Gln His Leu Gln Lys Asp Phe Phe Leu Tyr Asn 
        515                 520                 525             


Ala Ser Lys Ala Arg Ser Lys Xaa Tyr Ile Asn Met Arg Glu Val Ser 
    530                 535                 540                 


Gln Arg Phe Arg Leu Pro Pro Ser Glu Tyr Val Ile Val Pro Ser Xaa 
545                 550                 555                 560 


Tyr Glu Pro His Gln Glu Gly Glu Phe Ile Leu Arg Val Phe Ser Glu 
                565                 570                 575     


Lys Arg Asn Leu Ser Glu Glu Val Glu Asn Xaa Ile Ser Val Asp Arg 
            580                 585                 590         


Pro Val Lys Lys Lys Lys Xaa Lys Pro Ile Ile Phe Val Ser Asp Arg 
        595                 600                 605             


Ala Asn Ser Asn Lys Glu Leu Gly Val Asp Gln Glu Ser Glu Glu Gly 
    610                 615                 620                 


Lys Gly Lys Xaa Ser Pro Asp Lys Gln Lys Gln Ser Pro Gln Pro Gln 
625                 630                 635                 640 


Pro Gly Ser Ser Asp Gln Glu Ser Glu Glu Gln Gln Gln Phe Arg Asn 
                645                 650                 655     


Ile Phe Lys Gln Ile Ala Gly Asp Asp Met Glu Ile Cys Ala Asp Glu 
            660                 665                 670         


Leu Lys Lys Val Leu Asn Xaa Val Val Asn Lys His Lys Asp Leu Lys 
        675                 680                 685             


Xaa His Gly Phe Xaa Leu Glu Ser Cys Arg Ser Met Ile Ala Leu Met 
    690                 695                 700                 


Asp Xaa Asp Gly Ser Gly Lys Leu Asn Leu Gln Glu Phe His His Leu 
705                 710                 715                 720 


Trp Asn Lys Ile Lys Ala Trp Gln Lys Ile Phe Lys His Tyr Asp Xaa 
                725                 730                 735     


Asp Gln Ser Gly Xaa Ile Asn Ser Tyr Glu Met Arg Asn Ala Val Asn 
            740                 745                 750         


Asp Ala Gly Phe His Leu Asn Asn Gln Leu Tyr Asp Ile Ile Xaa Met 
        755                 760                 765             


Arg Tyr Ala Asp Lys His Met Asn Ile Asp Phe Asp Ser Phe Ile Cys 
    770                 775                 780                 


Cys Phe Val Arg Leu Glu Gly Met Phe Arg Ala Phe His Ala Phe Asp 
785                 790                 795                 800 


Lys Asp Gly Asp Gly Ile Ile Lys Leu Asn Val Leu Glu Trp Leu Gln 
                805                 810                 815     


Leu Xaa Met Tyr Ala 
            820     


<210> 4929
<211> 67
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 4929
Xaa Phe His Leu Asn Asn Gln Leu Tyr Asp Ile Ile Xaa Met Arg Tyr 
1               5                   10                  15      


Ala Asp Lys His Met Asn Ile Asp Phe Asp Ser Phe Ile Cys Cys Phe 
            20                  25                  30          


Val Arg Leu Glu Gly Met Phe Arg Ala Phe His Ala Phe Asp Lys Asp 
        35                  40                  45              


Gly Asp Gly Ile Ile Lys Leu Asn Val Leu Glu Trp Leu Gln Leu Xaa 
    50                  55                  60                  


Met Tyr Ala 
65          


<210> 4930
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<400> 4930
Xaa Gly Asn Lys Gln His Leu Gln Lys Asp Phe Phe Leu Tyr Asn Ala 
1               5                   10                  15      


Ser Lys Ala Arg Ser Lys Xaa Tyr Ile Asn Met Arg Glu Val Ser Gln 
            20                  25                  30          


Arg Phe Arg Leu Pro Pro Ser Glu Tyr Val Ile Val Pro Ser Xaa Tyr 
        35                  40                  45              


Glu Pro His Gln Glu Gly Glu Phe Ile Leu Arg Val Phe Ser Glu Lys 
    50                  55                  60                  


Arg Asn Leu Ser Glu Glu Val Glu Asn Xaa Ile Ser Val Asp Arg Pro 
65                  70                  75                  80  


Val Lys Lys Lys Lys Xaa Lys Pro Ile Ile Phe Val Ser Asp Arg Ala 
                85                  90                  95      


Asn Ser Asn Lys Glu Leu Gly Val Asp Gln Glu Ser Glu Glu Gly Lys 
            100                 105                 110         


Gly Lys Xaa Ser Pro Asp Lys Gln Lys Gln Ser Pro Gln Phe Ser Phe 
        115                 120                 125             


Val Pro Pro Gln Pro Gln Pro Gly Ser Ser Asp Gln Glu Ser Glu Glu 
    130                 135                 140                 


Gln Gln Gln Phe Arg Asn Ile Phe Lys Gln Ile Ala Gly Asp Asp Met 
145                 150                 155                 160 


Glu Ile Cys Ala Asp Glu Leu Lys Lys Val Leu Asn Xaa Val Val Asn 
                165                 170                 175     


Lys His Lys Asp Leu Lys Xaa His Gly Phe Xaa Leu 
            180                 185             


<210> 4931
<211> 169
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 4931
Xaa Ser Pro Gln Pro Gln Pro Gly Ser Ser Asp Gln Glu Ser Glu Glu 
1               5                   10                  15      


Gln Gln Gln Phe Arg Asn Ile Phe Lys Gln Ile Ala Gly Asp Asp Met 
            20                  25                  30          


Glu Ile Cys Ala Asp Glu Leu Lys Lys Val Leu Asn Xaa Val Val Asn 
        35                  40                  45              


Lys His Lys Asp Leu Lys Xaa His Gly Phe Xaa Leu Glu Ser Cys Arg 
    50                  55                  60                  


Ser Met Ile Ala Leu Met Asp Xaa Asp Gly Ser Gly Lys Leu Asn Leu 
65                  70                  75                  80  


Gln Glu Phe His His Leu Trp Asn Lys Ile Lys Ala Trp Gln Met Arg 
                85                  90                  95      


Asn Ala Val Asn Asp Ala Gly Phe His Leu Asn Asn Gln Leu Tyr Asp 
            100                 105                 110         


Ile Ile Xaa Met Arg Tyr Ala Asp Lys His Met Asn Ile Asp Phe Asp 
        115                 120                 125             


Ser Phe Ile Cys Cys Phe Val Arg Leu Glu Gly Met Phe Arg Ala Phe 
    130                 135                 140                 


His Ala Phe Asp Lys Asp Gly Asp Gly Ile Ile Lys Leu Asn Val Leu 
145                 150                 155                 160 


Glu Trp Leu Gln Leu Xaa Met Tyr Ala 
                165                 


<210> 4932
<211> 52
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 4932
Met Phe Ser Cys Val Lys Pro Tyr Glu Asp Gln Asn Tyr Ser Ala Leu 
1               5                   10                  15      


Arg Arg Asp Cys Arg Arg Arg Lys Val Leu Phe Glu Asp Pro Leu Phe 
            20                  25                  30          


Pro Ala Xaa Asp Asp Ser Leu Tyr Tyr Lys Gly Xaa Pro Gly Pro Ala 
        35                  40                  45              


Val Arg Cys Xaa 
    50          


<210> 4933
<211> 97
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<400> 4933
Met Phe Ser Cys Val Lys Pro Tyr Glu Asp Gln Asn Tyr Ser Ala Leu 
1               5                   10                  15      


Arg Arg Asp Cys Arg Arg Arg Lys Val Leu Phe Glu Asp Pro Leu Phe 
            20                  25                  30          


Pro Ala Xaa Asp Asp Ser Leu Tyr Tyr Lys Gly Xaa Pro Gly Pro Ala 
        35                  40                  45              


Val Arg Trp Lys Arg Pro Lys Gly Ile Cys Glu Asp Pro Arg Leu Phe 
    50                  55                  60                  


Val Asp Gly Ile Ser Ser His Asp Leu His Gln Gly Gln Val Gly Asn 
65                  70                  75                  80  


Cys Trp Phe Val Ala Ala Cys Ser Ser Leu Ala Ser Arg Glu Ser Leu 
                85                  90                  95      


Trp 
    


<210> 4934
<211> 640
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<400> 4934
Met Phe Ser Cys Val Lys Pro Tyr Glu Asp Gln Asn Tyr Ser Ala Leu 
1               5                   10                  15      


Arg Arg Asp Cys Arg Arg Arg Lys Val Leu Phe Glu Asp Pro Leu Phe 
            20                  25                  30          


Pro Ala Xaa Asp Asp Ser Leu Tyr Tyr Lys Gly Xaa Pro Gly Pro Ala 
        35                  40                  45              


Val Arg Trp Lys Arg Pro Lys Gly Ile Cys Glu Asp Pro Arg Leu Phe 
    50                  55                  60                  


Val Asp Gly Ile Ser Ser His Asp Leu His Gln Gly Gln Val Gly Asn 
65                  70                  75                  80  


Cys Trp Phe Val Ala Ala Cys Ser Ser Leu Ala Ser Arg Glu Ser Leu 
                85                  90                  95      


Trp Gln Lys Val Ile Pro Asp Trp Lys Glu Gln Glu Trp Asp Pro Glu 
            100                 105                 110         


Lys Pro Asn Ala Tyr Ala Gly Ile Phe His Phe His Phe Trp Arg Phe 
        115                 120                 125             


Gly Glu Trp Val Asp Val Val Ile Asp Asp Arg Leu Pro Xaa Val Asn 
    130                 135                 140                 


Asn Gln Leu Ile Tyr Cys His Ser Asn Ser Arg Asn Glu Phe Trp Cys 
145                 150                 155                 160 


Ala Leu Val Glu Lys Ala Tyr Ala Lys Leu Ala Gly Cys Tyr Gln Ala 
                165                 170                 175     


Leu Asp Gly Gly Asn Xaa Ala Asp Ala Leu Val Asp Phe Xaa Gly Gly 
            180                 185                 190         


Val Ser Glu Pro Ile Asp Leu Xaa Glu Gly Asp Phe Ala Asn Asp Glu 
        195                 200                 205             


Xaa Lys Arg Asn Gln Leu Phe Glu Arg Met Leu Lys Val His Ser Arg 
    210                 215                 220                 


Gly Gly Leu Ile Ser Ala Ser Ile Lys Ala Val Xaa Ala Ala Asp Met 
225                 230                 235                 240 


Glu Ala Arg Leu Ala Cys Gly Leu Val Lys Gly His Ala Tyr Ala Val 
                245                 250                 255     


Xaa Asp Val Arg Lys Val Arg Leu Gly His Gly Leu Leu Ala Phe Phe 
            260                 265                 270         


Lys Ser Glu Lys Leu Asp Met Ile Arg Leu Arg Asn Pro Trp Gly Glu 
        275                 280                 285             


Arg Glu Trp Asn Gly Pro Trp Ser Asp Xaa Ser Glu Glu Trp Gln Lys 
    290                 295                 300                 


Val Ser Lys Ser Glu Arg Glu Lys Met Gly Val Xaa Val Gln Asp Asp 
305                 310                 315                 320 


Gly Glu Phe Trp Met Xaa Phe Glu Asp Val Cys Arg Tyr Phe Xaa Asp 
                325                 330                 335     


Ile Ile Lys Cys Arg Val Ile Asn Xaa Ser His Leu Ser Ile His Lys 
            340                 345                 350         


Xaa Trp Glu Glu Ala Arg Leu His Gly Ala Trp Xaa Leu His Glu Asp 
        355                 360                 365             


Pro Arg Gln Asn Arg Gly Gly Gly Cys Ile Asn His Lys Asp Xaa Phe 
    370                 375                 380                 


Phe Gln Asn Pro Gln Tyr Ile Phe Glu Val Lys Lys Pro Glu Asp Glu 
385                 390                 395                 400 


Val Leu Ile Cys Ile Gln Gln Arg Pro Lys Arg Ser Xaa Arg Arg Glu 
                405                 410                 415     


Gly Lys Gly Glu Asn Leu Ala Ile Gly Phe Asp Ile Tyr Lys Val Glu 
            420                 425                 430         


Glu Asn Arg Gln Tyr Arg Met His Ser Leu Gln His Lys Ala Ala Ser 
        435                 440                 445             


Ser Ile Tyr Ile Asn Ser Arg Ser Val Phe Leu Arg Xaa Asp Gln Pro 
    450                 455                 460                 


Glu Gly Arg Tyr Val Ile Ile Pro Xaa Xaa Phe Glu Pro Gly His Xaa 
465                 470                 475                 480 


Gly Glu Phe Leu Leu Arg Val Phe Xaa Asp Val Pro Ser Asn Cys Arg 
                485                 490                 495     


Glu Leu Arg Leu Asp Glu Pro Pro His Xaa Cys Trp Ser Ser Leu Cys 
            500                 505                 510         


Gly Tyr Pro Gln Leu Val Xaa Gln Val His Val Leu Gly Ala Ala Gly 
        515                 520                 525             


Leu Lys Asp Ser Pro Xaa Gly Ala Asn Ser Tyr Val Ile Ile Lys Cys 
    530                 535                 540                 


Glu Gly Asp Lys Val Arg Ser Ala Val Gln Lys Gly Xaa Ser Xaa Pro 
545                 550                 555                 560 


Glu Tyr Asn Val Lys Gly Ile Phe Tyr Arg Lys Lys Leu Ser Gln Pro 
                565                 570                 575     


Ile Xaa Val Gln Val Trp Asn His Arg Val Leu Lys Asp Glu Phe Leu 
            580                 585                 590         


Gly Gln Val His Leu Lys Ala Asp Pro Asp Asn Leu Gln Ala Leu His 
        595                 600                 605             


Xaa Leu His Leu Arg Asp Arg Asn Ser Arg Gln Pro Ser Asn Leu Pro 
    610                 615                 620                 


Gly Xaa Val Ala Val His Ile Leu Ser Ser Xaa Ser Leu Met Ala Val 
625                 630                 635                 640 


<210> 4935
<211> 680
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<400> 4935
Met Phe Ser Cys Val Lys Pro Tyr Glu Asp Gln Asn Tyr Ser Ala Leu 
1               5                   10                  15      


Arg Arg Asp Cys Arg Arg Arg Lys Val Leu Phe Glu Asp Pro Leu Phe 
            20                  25                  30          


Pro Ala Xaa Asp Asp Ser Leu Tyr Tyr Lys Gly Xaa Pro Gly Pro Ala 
        35                  40                  45              


Val Arg Trp Lys Arg Pro Lys Tyr Ser Gly His Ser Leu Ala Pro His 
    50                  55                  60                  


Arg Pro Gly Trp Gly Asp Ala Arg Arg Met Glu Asn Val Pro Arg Pro 
65                  70                  75                  80  


Gly Ser Ser Gly Cys Pro Ser Ser Ser Leu Arg Ala Arg Asp Leu Gly 
                85                  90                  95      


Ile Cys Glu Asp Pro Arg Leu Phe Val Asp Gly Ile Ser Ser His Asp 
            100                 105                 110         


Leu His Gln Gly Gln Val Gly Asn Cys Trp Phe Val Ala Ala Cys Ser 
        115                 120                 125             


Ser Leu Ala Ser Arg Glu Ser Leu Trp Gln Lys Val Ile Pro Asp Trp 
    130                 135                 140                 


Lys Glu Gln Glu Trp Asp Pro Glu Lys Pro Asn Ala Tyr Ala Gly Ile 
145                 150                 155                 160 


Phe His Phe His Phe Trp Arg Phe Gly Glu Trp Val Asp Val Val Ile 
                165                 170                 175     


Asp Asp Arg Leu Pro Xaa Val Asn Asn Gln Leu Ile Tyr Cys His Ser 
            180                 185                 190         


Asn Ser Arg Asn Glu Phe Trp Cys Ala Leu Val Glu Lys Ala Tyr Ala 
        195                 200                 205             


Lys Leu Ala Gly Cys Tyr Gln Ala Leu Asp Gly Gly Asn Xaa Ala Asp 
    210                 215                 220                 


Ala Leu Val Asp Phe Xaa Gly Gly Val Ser Glu Pro Ile Asp Leu Xaa 
225                 230                 235                 240 


Glu Gly Asp Phe Ala Asn Asp Glu Xaa Lys Arg Asn Gln Leu Phe Glu 
                245                 250                 255     


Arg Met Leu Lys Val His Ser Arg Gly Gly Leu Ile Ser Ala Ser Ile 
            260                 265                 270         


Lys Ala Val Xaa Ala Ala Asp Met Glu Ala Arg Leu Ala Cys Gly Leu 
        275                 280                 285             


Val Lys Gly His Ala Tyr Ala Val Xaa Asp Val Arg Lys Val Arg Leu 
    290                 295                 300                 


Gly His Gly Leu Leu Ala Phe Phe Lys Ser Glu Lys Leu Asp Met Ile 
305                 310                 315                 320 


Arg Leu Arg Asn Pro Trp Gly Glu Arg Glu Trp Asn Gly Pro Trp Ser 
                325                 330                 335     


Asp Xaa Ser Glu Glu Trp Gln Lys Val Ser Lys Ser Glu Arg Glu Lys 
            340                 345                 350         


Met Gly Val Xaa Val Gln Asp Asp Gly Glu Phe Trp Met Xaa Phe Glu 
        355                 360                 365             


Asp Val Cys Arg Tyr Phe Xaa Asp Ile Ile Lys Cys Arg Val Ile Asn 
    370                 375                 380                 


Xaa Ser His Leu Ser Ile His Lys Xaa Trp Glu Glu Ala Arg Leu His 
385                 390                 395                 400 


Gly Ala Trp Xaa Leu His Glu Asp Pro Arg Gln Asn Arg Gly Gly Gly 
                405                 410                 415     


Cys Ile Asn His Lys Asp Xaa Phe Phe Gln Asn Pro Gln Tyr Ile Phe 
            420                 425                 430         


Glu Val Lys Lys Pro Glu Asp Glu Val Leu Ile Cys Ile Gln Gln Arg 
        435                 440                 445             


Pro Lys Arg Ser Xaa Arg Arg Glu Gly Lys Gly Glu Asn Leu Ala Ile 
    450                 455                 460                 


Gly Phe Asp Ile Tyr Lys Val Glu Glu Asn Arg Gln Tyr Arg Met His 
465                 470                 475                 480 


Ser Leu Gln His Lys Ala Ala Ser Ser Ile Tyr Ile Asn Ser Arg Ser 
                485                 490                 495     


Val Phe Leu Arg Xaa Asp Gln Pro Glu Gly Arg Tyr Val Ile Ile Pro 
            500                 505                 510         


Xaa Xaa Phe Glu Pro Gly His Xaa Gly Glu Phe Leu Leu Arg Val Phe 
        515                 520                 525             


Xaa Asp Val Pro Ser Asn Cys Arg Glu Leu Arg Leu Asp Glu Pro Pro 
    530                 535                 540                 


His Xaa Cys Trp Ser Ser Leu Cys Gly Tyr Pro Gln Leu Val Xaa Gln 
545                 550                 555                 560 


Val His Val Leu Gly Ala Ala Gly Leu Lys Asp Ser Pro Xaa Gly Ala 
                565                 570                 575     


Asn Ser Tyr Val Ile Ile Lys Cys Glu Gly Asp Lys Val Arg Ser Ala 
            580                 585                 590         


Val Gln Lys Gly Xaa Ser Xaa Pro Glu Tyr Asn Val Lys Gly Ile Phe 
        595                 600                 605             


Tyr Arg Lys Lys Leu Ser Gln Pro Ile Xaa Val Gln Val Trp Asn His 
    610                 615                 620                 


Arg Val Leu Lys Asp Glu Phe Leu Gly Gln Val His Leu Lys Ala Asp 
625                 630                 635                 640 


Pro Asp Asn Leu Gln Ala Leu His Xaa Leu His Leu Arg Asp Arg Asn 
                645                 650                 655     


Ser Arg Gln Pro Ser Asn Leu Pro Gly Xaa Val Ala Val His Ile Leu 
            660                 665                 670         


Ser Ser Xaa Ser Leu Met Ala Val 
        675                 680 


<210> 4936
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<400> 4936
Glu Asp Tyr Lys Asp Arg Leu Lys Ser Gly Glu His Leu Asn Pro Asp 
1               5                   10                  15      


Gln Leu Glu Ala Val Glu Lys Tyr Glu Glu Val Leu His Asn Leu Glu 
            20                  25                  30          


Phe Ala Lys Glu Leu Gln Lys Xaa Phe Ser Gly Leu Ser Leu Asp Leu 
        35                  40                  45              


Leu Lys Ala Gln Lys Lys Ala Gln Arg Arg Glu His Met Leu Lys Leu 
    50                  55                  60                  


Glu Ala Glu Lys Lys Lys Leu Arg Xaa Ile Leu Gln Val Gln Tyr Val 
65                  70                  75                  80  


Leu Gln Asn Leu Xaa Gln Glu His Val Gln Lys Asp Phe Lys Gly Gly 
                85                  90                  95      


Leu Asn Gly Ala Val Tyr Leu Pro Ser Lys Glu Leu Asp Tyr Leu Ile 
            100                 105                 110         


Lys Phe Ser Lys Leu Xaa Cys Pro Glu Arg Asn Glu Ser Leu Arg Gln 
        115                 120                 125             


Xaa Leu Glu Gly Ser Xaa Val 
    130                 135 


<210> 4937
<211> 706
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<400> 4937
Ile Lys Phe Ser Lys Leu Xaa Cys Pro Glu Arg Asn Glu Ser Leu Ser 
1               5                   10                  15      


Val Glu Asp Gln Met Glu Gln Ser Ser Leu Tyr Phe Trp Asp Leu Leu 
            20                  25                  30          


Glu Gly Ser Glu Lys Ala Val Val Gly Xaa Xaa Tyr Lys His Leu Lys 
        35                  40                  45              


Asp Leu Leu Ser Lys Leu Leu Asn Ser Gly Tyr Phe Glu Ser Ile Pro 
    50                  55                  60                  


Val Pro Lys Asn Ala Lys Glu Lys Glu Val Pro Leu Glu Glu Glu Met 
65                  70                  75                  80  


Leu Ile Gln Ser Glu Lys Lys Xaa Gln Leu Ser Lys Xaa Glu Ser Val 
                85                  90                  95      


Lys Glu Ser Glu Ser Leu Met Glu Phe Ala Gln Pro Glu Ile Gln Pro 
            100                 105                 110         


Gln Glu Phe Leu Asn Arg Arg Tyr Met Xaa Glu Val Asp Tyr Ser Asn 
        115                 120                 125             


Lys Gln Gly Glu Glu Gln Pro Trp Glu Ala Asp Tyr Ala Arg Lys Pro 
    130                 135                 140                 


Asn Leu Pro Lys Arg Trp Asp Met Leu Xaa Glu Pro Asp Gly Gln Glu 
145                 150                 155                 160 


Lys Lys Gln Glu Ser Phe Lys Ser Trp Glu Ala Ser Gly Lys His Gln 
                165                 170                 175     


Glu Val Ser Lys Pro Ala Val Ser Leu Glu Gln Arg Lys Gln Asp Xaa 
            180                 185                 190         


Ser Lys Leu Arg Ser Xaa Leu Pro Glu Glu Gln Lys Lys Gln Glu Ile 
        195                 200                 205             


Ser Lys Ser Lys Pro Ser Pro Ser Gln Trp Lys Gln Asp Xaa Pro Lys 
    210                 215                 220                 


Ser Lys Ala Gly Tyr Val Gln Glu Glu Gln Lys Lys Gln Glu Xaa Pro 
225                 230                 235                 240 


Lys Leu Trp Pro Val Gln Leu Gln Lys Glu Gln Asp Pro Lys Lys Gln 
                245                 250                 255     


Xaa Pro Lys Ser Trp Xaa Pro Ser Met Gln Ser Glu Gln Asn Xaa Xaa 
            260                 265                 270         


Lys Ser Trp Xaa Xaa Pro Met Cys Glu Glu Gln Asp Ser Lys Gln Pro 
        275                 280                 285             


Glu Xaa Pro Lys Ser Trp Glu Asn Asn Val Glu Ser Gln Lys His Ser 
    290                 295                 300                 


Leu Xaa Ser Gln Ser Gln Ile Ser Pro Lys Ser Trp Gly Val Ala Xaa 
305                 310                 315                 320 


Ala Ser Leu Ile Pro Asn Asp Gln Leu Leu Pro Arg Lys Leu Asn Xaa 
                325                 330                 335     


Glu Pro Lys Asp Val Pro Lys Pro Val His Gln Pro Val Gly Ser Ser 
            340                 345                 350         


Ser Xaa Leu Pro Lys Asp Pro Val Leu Arg Lys Glu Lys Leu Gln Asp 
        355                 360                 365             


Leu Met Xaa Gln Ile Gln Gly Xaa Cys Asn Phe Met Gln Glu Ser Val 
    370                 375                 380                 


Leu Asp Phe Asp Lys Pro Ser Ser Ala Ile Pro Xaa Ser Gln Pro Pro 
385                 390                 395                 400 


Ser Ala Xaa Pro Gly Ser Pro Val Ala Ser Lys Glu Gln Asn Leu Ser 
                405                 410                 415     


Ser Gln Ser Asp Phe Leu Gln Glu Pro Leu Gln Ala Xaa Ser Ser Pro 
            420                 425                 430         


Val Xaa Cys Ser Ser Asn Ala Cys Leu Val Xaa Xaa Asp Gln Ala Ser 
        435                 440                 445             


Ser Gly Ser Glu Xaa Glu Phe Met Xaa Ser Glu Xaa Pro Glu Ala Ala 
    450                 455                 460                 


Ile Pro Pro Gly Lys Gln Pro Ser Ser Leu Ala Ser Pro Asn Pro Pro 
465                 470                 475                 480 


Met Ala Lys Gly Ser Glu Gln Gly Phe Gln Ser Pro Pro Ala Ser Ser 
                485                 490                 495     


Ser Ser Val Xaa Ile Asn Xaa Ala Pro Phe Gln Ala Met Gln Xaa Val 
            500                 505                 510         


Phe Asn Val Asn Ala Pro Leu Pro Pro Arg Lys Glu Gln Glu Ile Lys 
        515                 520                 525             


Glu Ser Pro Tyr Ser Pro Gly Tyr Asn Gln Ser Phe Xaa Xaa Ala Ser 
    530                 535                 540                 


Xaa Gln Xaa Pro Pro Gln Cys Gln Leu Pro Ser Ile His Val Glu Gln 
545                 550                 555                 560 


Xaa Val His Ser Gln Glu Xaa Ala Asn Tyr His Pro Asp Gly Xaa Ile 
                565                 570                 575     


Gln Val Ser Asn Gly Ser Leu Ala Phe Tyr Pro Ala Gln Xaa Asn Val 
            580                 585                 590         


Phe Pro Arg Pro Xaa Gln Pro Phe Val Asn Ser Arg Gly Ser Val Arg 
        595                 600                 605             


Gly Cys Xaa Arg Gly Gly Arg Leu Ile Xaa Asn Ser Tyr Arg Ser Pro 
    610                 615                 620                 


Gly Gly Tyr Lys Gly Phe Asp Xaa Tyr Arg Gly Leu Pro Ser Ile Ser 
625                 630                 635                 640 


Asn Gly Asn Tyr Ser Gln Leu Gln Phe Gln Ala Arg Glu Tyr Ser Gly 
                645                 650                 655     


Ala Pro Tyr Ser Gln Arg Cys Leu Glu Xaa Ser Glu Pro Leu Trp Leu 
            660                 665                 670         


Leu Gly Lys Ala Arg Ile Ile Ser Ser Ser Val Ile Ser Glu Glu Gly 
        675                 680                 685             


His Leu Val Val His Glu Gln Ile Arg Glu Gln Gly Gly Val Ile Leu 
    690                 695                 700                 


Leu Arg 
705     


<210> 4938
<211> 278
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<400> 4938
Met Glu Val Gln Val Ser Gln Ala Ser Leu Gly Phe Glu Leu Xaa Ser 
1               5                   10                  15      


Val Glu Lys Ser Leu Arg Glu Trp Ser Arg Leu Ser Arg Glu Val Ile 
            20                  25                  30          


Ala Trp Leu Cys Pro Ser Ser Pro Asn Phe Ile Leu Asn Phe Pro Pro 
        35                  40                  45              


Pro Pro Ser Ala Ser Ser Val Ser Met Val Gln Leu Phe Ser Ser Pro 
    50                  55                  60                  


Phe Gly Tyr Gln Ser Pro Ser Gly His Ser Glu Glu Glu Arg Glu Gly 
65                  70                  75                  80  


Asn Met Lys Ser Ala Lys Pro Gln Val Asn His Ser Gln His Gly Glu 
                85                  90                  95      


Ser Gln Arg Ala Leu Ser Pro Leu Gln Ser Xaa Leu Ser Ser Ala Ala 
            100                 105                 110         


Ser Pro Ser Gln Ala Tyr Glu Xaa Tyr Ile Glu Asn Gly Leu Ile Cys 
        115                 120                 125             


Leu Lys His Lys Ile Arg Asn Ile Glu Lys Lys Lys Leu Lys Leu Glu 
    130                 135                 140                 


Asp Tyr Lys Asp Arg Leu Lys Ser Gly Glu His Leu Asn Pro Asp Gln 
145                 150                 155                 160 


Leu Glu Ala Val Glu Lys Tyr Glu Glu Val Leu His Asn Leu Glu Phe 
                165                 170                 175     


Ala Lys Glu Leu Gln Lys Xaa Phe Ser Gly Leu Ser Leu Asp Leu Leu 
            180                 185                 190         


Lys Ala Gln Lys Lys Ala Gln Arg Arg Glu His Met Leu Lys Leu Glu 
        195                 200                 205             


Ala Glu Lys Lys Lys Leu Arg Xaa Ile Leu Gln Val Gln Tyr Val Leu 
    210                 215                 220                 


Gln Asn Leu Xaa Gln Glu His Val Gln Lys Asp Phe Lys Gly Gly Leu 
225                 230                 235                 240 


Asn Gly Ala Val Tyr Leu Pro Ser Lys Glu Leu Asp Tyr Leu Ile Lys 
                245                 250                 255     


Phe Ser Lys Leu Xaa Cys Pro Glu Arg Asn Glu Ser Leu Arg Gln Xaa 
            260                 265                 270         


Leu Glu Gly Ser Xaa Val 
        275             


<210> 4939
<211> 905
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (873)..(873)
<223> Selenocysteine

<400> 4939
Met Glu Val Gln Val Ser Gln Ala Ser Leu Gly Phe Glu Leu Xaa Ser 
1               5                   10                  15      


Val Glu Lys Ser Leu Arg Glu Trp Ser Arg Leu Ser Arg Glu Val Ile 
            20                  25                  30          


Ala Trp Leu Cys Pro Ser Ser Pro Asn Phe Ile Leu Asn Phe Pro Pro 
        35                  40                  45              


Pro Pro Ser Ala Ser Ser Val Ser Met Val Gln Leu Phe Ser Ser Pro 
    50                  55                  60                  


Phe Gly Tyr Gln Ser Pro Ser Gly His Ser Glu Glu Glu Arg Glu Gly 
65                  70                  75                  80  


Asn Met Lys Ser Ala Lys Pro Gln Val Asn His Ser Gln His Gly Glu 
                85                  90                  95      


Ser Gln Arg Ala Leu Ser Pro Leu Gln Ser Xaa Leu Ser Ser Ala Ala 
            100                 105                 110         


Ser Pro Ser Gln Ala Tyr Glu Xaa Tyr Ile Glu Asn Gly Leu Ile Cys 
        115                 120                 125             


Leu Lys His Lys Ile Arg Asn Ile Glu Lys Lys Lys Leu Lys Leu Glu 
    130                 135                 140                 


Asp Tyr Lys Asp Arg Leu Lys Ser Gly Glu His Leu Asn Pro Asp Gln 
145                 150                 155                 160 


Leu Glu Ala Val Glu Lys Tyr Glu Glu Val Leu His Asn Leu Glu Phe 
                165                 170                 175     


Ala Lys Glu Leu Gln Lys Xaa Phe Ser Gly Leu Ser Leu Asp Leu Leu 
            180                 185                 190         


Lys Ala Gln Lys Lys Ala Gln Arg Arg Glu His Met Leu Lys Leu Glu 
        195                 200                 205             


Ala Glu Lys Lys Lys Leu Arg Xaa Ile Leu Gln Val Gln Tyr Val Leu 
    210                 215                 220                 


Gln Asn Leu Xaa Gln Glu His Val Gln Lys Asp Phe Lys Gly Gly Leu 
225                 230                 235                 240 


Asn Gly Ala Val Tyr Leu Pro Ser Lys Glu Leu Asp Tyr Leu Ile Lys 
                245                 250                 255     


Phe Ser Lys Leu Xaa Cys Pro Glu Arg Asn Glu Ser Leu Ser Val Glu 
            260                 265                 270         


Asp Gln Met Glu Gln Ser Ser Leu Tyr Phe Trp Asp Leu Leu Glu Gly 
        275                 280                 285             


Ser Glu Lys Ala Val Val Gly Xaa Xaa Tyr Lys His Leu Lys Asp Leu 
    290                 295                 300                 


Leu Ser Lys Leu Leu Asn Ser Gly Tyr Phe Glu Ser Ile Pro Val Pro 
305                 310                 315                 320 


Lys Asn Ala Lys Glu Lys Glu Val Pro Leu Glu Glu Glu Met Leu Ile 
                325                 330                 335     


Gln Ser Glu Lys Lys Xaa Gln Leu Ser Lys Xaa Glu Ser Val Lys Glu 
            340                 345                 350         


Ser Glu Ser Leu Met Glu Phe Ala Gln Pro Glu Ile Gln Pro Gln Glu 
        355                 360                 365             


Phe Leu Asn Arg Arg Tyr Met Xaa Glu Val Asp Tyr Ser Asn Lys Gln 
    370                 375                 380                 


Gly Glu Glu Gln Pro Trp Glu Ala Asp Tyr Ala Arg Lys Pro Asn Leu 
385                 390                 395                 400 


Pro Lys Arg Trp Asp Met Leu Xaa Glu Pro Asp Gly Gln Glu Lys Lys 
                405                 410                 415     


Gln Glu Ser Phe Lys Ser Trp Glu Ala Ser Gly Lys His Gln Glu Val 
            420                 425                 430         


Ser Lys Pro Ala Val Ser Leu Glu Gln Arg Lys Gln Asp Xaa Ser Lys 
        435                 440                 445             


Leu Arg Ser Xaa Leu Pro Glu Glu Gln Lys Lys Gln Glu Ile Ser Lys 
    450                 455                 460                 


Ser Lys Pro Ser Pro Ser Gln Trp Lys Gln Asp Xaa Pro Lys Ser Lys 
465                 470                 475                 480 


Ala Gly Tyr Val Gln Glu Glu Gln Lys Lys Gln Glu Xaa Pro Lys Leu 
                485                 490                 495     


Trp Pro Val Gln Leu Gln Lys Glu Gln Asp Pro Lys Lys Gln Xaa Pro 
            500                 505                 510         


Lys Ser Trp Xaa Pro Ser Met Gln Ser Glu Gln Asn Xaa Xaa Lys Ser 
        515                 520                 525             


Trp Xaa Xaa Pro Met Cys Glu Glu Gln Asp Ser Lys Gln Pro Glu Xaa 
    530                 535                 540                 


Pro Lys Ser Trp Glu Asn Asn Val Glu Ser Gln Lys His Ser Leu Xaa 
545                 550                 555                 560 


Ser Gln Ser Gln Ile Ser Pro Lys Ser Trp Gly Val Ala Xaa Ala Ser 
                565                 570                 575     


Leu Ile Pro Asn Asp Gln Leu Leu Pro Arg Lys Leu Asn Xaa Glu Pro 
            580                 585                 590         


Lys Asp Val Pro Lys Pro Val His Gln Pro Val Gly Ser Ser Ser Xaa 
        595                 600                 605             


Leu Pro Lys Asp Pro Val Leu Arg Lys Glu Lys Leu Gln Asp Leu Met 
    610                 615                 620                 


Xaa Gln Ile Gln Gly Xaa Cys Asn Phe Met Gln Glu Ser Val Leu Asp 
625                 630                 635                 640 


Phe Asp Lys Pro Ser Ser Ala Ile Pro Xaa Ser Gln Pro Pro Ser Ala 
                645                 650                 655     


Xaa Pro Gly Ser Pro Val Ala Ser Lys Glu Gln Asn Leu Ser Ser Gln 
            660                 665                 670         


Ser Asp Phe Leu Gln Glu Pro Leu Gln Ala Ala Ile Pro Pro Gly Lys 
        675                 680                 685             


Gln Pro Ser Ser Leu Ala Ser Pro Asn Pro Pro Met Ala Lys Gly Ser 
    690                 695                 700                 


Glu Gln Gly Phe Gln Ser Pro Pro Ala Ser Ser Ser Ser Val Xaa Ile 
705                 710                 715                 720 


Asn Xaa Ala Pro Phe Gln Ala Met Gln Xaa Val Phe Asn Val Asn Ala 
                725                 730                 735     


Pro Leu Pro Pro Arg Lys Glu Gln Glu Ile Lys Glu Ser Pro Tyr Ser 
            740                 745                 750         


Pro Gly Tyr Asn Gln Ser Phe Xaa Xaa Ala Ser Xaa Gln Xaa Pro Pro 
        755                 760                 765             


Gln Cys Gln Leu Pro Ser Ile His Val Glu Gln Xaa Val His Ser Gln 
    770                 775                 780                 


Glu Xaa Ala Gln Xaa Asn Val Phe Pro Arg Pro Xaa Gln Pro Phe Val 
785                 790                 795                 800 


Asn Ser Arg Gly Ser Val Arg Gly Cys Xaa Arg Gly Gly Arg Leu Ile 
                805                 810                 815     


Xaa Asn Ser Tyr Arg Ser Pro Gly Gly Tyr Lys Gly Phe Asp Xaa Tyr 
            820                 825                 830         


Arg Gly Leu Pro Ser Ile Ser Asn Gly Asn Tyr Ser Gln Leu Gln Phe 
        835                 840                 845             


Gln Ala Arg Glu Tyr Ser Gly Ala Pro Tyr Ser Gln Arg Asp Asn Phe 
    850                 855                 860                 


Gln Gln Cys Tyr Lys Arg Gly Gly Xaa Ser Gly Gly Pro Arg Ala Asn 
865                 870                 875                 880 


Ser Arg Ala Asn Cys Phe Ile Met Arg Asn Ser Leu Leu Leu Ile Lys 
                885                 890                 895     


Gln Gln Gly Gly Val Ile Leu Leu Arg 
            900                 905 


<210> 4940
<211> 960
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<400> 4940
Met Glu Val Gln Val Ser Gln Ala Ser Leu Gly Phe Glu Leu Xaa Ser 
1               5                   10                  15      


Val Glu Lys Ser Leu Arg Glu Trp Ser Arg Leu Ser Arg Glu Val Ile 
            20                  25                  30          


Ala Trp Leu Cys Pro Ser Ser Pro Asn Phe Ile Leu Asn Phe Pro Pro 
        35                  40                  45              


Pro Pro Ser Ala Ser Ser Val Ser Met Val Gln Leu Phe Ser Ser Pro 
    50                  55                  60                  


Phe Gly Tyr Gln Ser Pro Ser Gly His Ser Glu Glu Glu Arg Glu Gly 
65                  70                  75                  80  


Asn Met Lys Ser Ala Lys Pro Gln Val Asn His Ser Gln His Gly Glu 
                85                  90                  95      


Ser Gln Arg Ala Leu Ser Pro Leu Gln Ser Xaa Leu Ser Ser Ala Ala 
            100                 105                 110         


Ser Pro Ser Gln Ala Tyr Glu Xaa Tyr Ile Glu Asn Gly Leu Ile Cys 
        115                 120                 125             


Leu Lys His Lys Ile Arg Asn Ile Glu Lys Lys Lys Leu Lys Leu Glu 
    130                 135                 140                 


Asp Tyr Lys Asp Arg Leu Lys Ser Gly Glu His Leu Asn Pro Asp Gln 
145                 150                 155                 160 


Leu Glu Ala Val Glu Lys Tyr Glu Glu Val Leu His Asn Leu Glu Phe 
                165                 170                 175     


Ala Lys Glu Leu Gln Lys Xaa Phe Ser Gly Leu Ser Leu Asp Leu Leu 
            180                 185                 190         


Lys Ala Gln Lys Lys Ala Gln Arg Arg Glu His Met Leu Lys Leu Glu 
        195                 200                 205             


Ala Glu Lys Lys Lys Leu Arg Xaa Ile Leu Gln Val Gln Tyr Val Leu 
    210                 215                 220                 


Gln Asn Leu Xaa Gln Glu His Val Gln Lys Asp Phe Lys Gly Gly Leu 
225                 230                 235                 240 


Asn Gly Ala Val Tyr Leu Pro Ser Lys Glu Leu Asp Tyr Leu Ile Lys 
                245                 250                 255     


Phe Ser Lys Leu Xaa Cys Pro Glu Arg Asn Glu Ser Leu Ser Val Glu 
            260                 265                 270         


Asp Gln Met Glu Gln Ser Ser Leu Tyr Phe Trp Asp Leu Leu Glu Gly 
        275                 280                 285             


Ser Glu Lys Ala Val Val Gly Xaa Xaa Tyr Lys His Leu Lys Asp Leu 
    290                 295                 300                 


Leu Ser Lys Leu Leu Asn Ser Gly Tyr Phe Glu Ser Ile Pro Val Pro 
305                 310                 315                 320 


Lys Asn Ala Lys Glu Lys Glu Val Pro Leu Glu Glu Glu Met Leu Ile 
                325                 330                 335     


Gln Ser Glu Lys Lys Xaa Gln Leu Ser Lys Xaa Glu Ser Val Lys Glu 
            340                 345                 350         


Ser Glu Ser Leu Met Glu Phe Ala Gln Pro Glu Ile Gln Pro Gln Glu 
        355                 360                 365             


Phe Leu Asn Arg Arg Tyr Met Xaa Glu Val Asp Tyr Ser Asn Lys Gln 
    370                 375                 380                 


Gly Glu Glu Gln Pro Trp Glu Ala Asp Tyr Ala Arg Lys Pro Asn Leu 
385                 390                 395                 400 


Pro Lys Arg Trp Asp Met Leu Xaa Glu Pro Asp Gly Gln Glu Lys Lys 
                405                 410                 415     


Gln Glu Ser Phe Lys Ser Trp Glu Ala Ser Gly Lys His Gln Glu Val 
            420                 425                 430         


Ser Lys Pro Ala Val Ser Leu Glu Gln Arg Lys Gln Asp Xaa Ser Lys 
        435                 440                 445             


Leu Arg Ser Xaa Leu Pro Glu Glu Gln Lys Lys Gln Glu Ile Ser Lys 
    450                 455                 460                 


Ser Lys Pro Ser Pro Ser Gln Trp Lys Gln Asp Xaa Pro Lys Ser Lys 
465                 470                 475                 480 


Ala Gly Tyr Val Gln Glu Glu Gln Lys Lys Gln Glu Xaa Pro Lys Leu 
                485                 490                 495     


Trp Pro Val Gln Leu Gln Lys Glu Gln Asp Pro Lys Lys Gln Xaa Pro 
            500                 505                 510         


Lys Ser Trp Xaa Pro Ser Met Gln Ser Glu Gln Asn Xaa Xaa Lys Ser 
        515                 520                 525             


Trp Xaa Xaa Pro Met Cys Glu Glu Gln Asp Ser Lys Gln Pro Glu Xaa 
    530                 535                 540                 


Pro Lys Ser Trp Glu Asn Asn Val Glu Ser Gln Lys His Ser Leu Xaa 
545                 550                 555                 560 


Ser Gln Ser Gln Ile Ser Pro Lys Ser Trp Gly Val Ala Xaa Ala Ser 
                565                 570                 575     


Leu Ile Pro Asn Asp Gln Leu Leu Pro Arg Lys Leu Asn Xaa Glu Pro 
            580                 585                 590         


Lys Asp Val Pro Lys Pro Val His Gln Pro Val Gly Ser Ser Ser Xaa 
        595                 600                 605             


Leu Pro Lys Asp Pro Val Leu Arg Lys Glu Lys Leu Gln Asp Leu Met 
    610                 615                 620                 


Xaa Gln Ile Gln Gly Xaa Cys Asn Phe Met Gln Glu Ser Val Leu Asp 
625                 630                 635                 640 


Phe Asp Lys Pro Ser Ser Ala Ile Pro Xaa Ser Gln Pro Pro Ser Ala 
                645                 650                 655     


Xaa Pro Gly Ser Pro Val Ala Ser Lys Glu Gln Asn Leu Ser Ser Gln 
            660                 665                 670         


Ser Asp Phe Leu Gln Glu Pro Leu Gln Ala Xaa Ser Ser Pro Val Xaa 
        675                 680                 685             


Cys Ser Ser Asn Ala Cys Leu Val Xaa Xaa Asp Gln Ala Ser Ser Gly 
    690                 695                 700                 


Ser Glu Xaa Glu Phe Met Xaa Ser Glu Xaa Pro Glu Ala Ala Ile Pro 
705                 710                 715                 720 


Pro Gly Lys Gln Pro Ser Ser Leu Ala Ser Pro Asn Pro Pro Met Ala 
                725                 730                 735     


Lys Gly Ser Glu Gln Gly Phe Gln Ser Pro Pro Ala Ser Ser Ser Ser 
            740                 745                 750         


Val Xaa Ile Asn Xaa Ala Pro Phe Gln Ala Met Gln Xaa Val Phe Asn 
        755                 760                 765             


Val Asn Ala Pro Leu Pro Pro Arg Lys Glu Gln Glu Ile Lys Glu Ser 
    770                 775                 780                 


Pro Tyr Ser Pro Gly Tyr Asn Gln Ser Phe Xaa Xaa Ala Ser Xaa Gln 
785                 790                 795                 800 


Xaa Pro Pro Gln Cys Gln Leu Pro Ser Ile His Val Glu Gln Xaa Val 
                805                 810                 815     


His Ser Gln Glu Xaa Ala Asn Tyr His Pro Asp Gly Xaa Ile Gln Val 
            820                 825                 830         


Ser Asn Gly Ser Leu Ala Phe Tyr Pro Ala Gln Xaa Asn Val Phe Pro 
        835                 840                 845             


Arg Pro Xaa Gln Pro Phe Val Asn Ser Arg Gly Ser Val Arg Gly Cys 
    850                 855                 860                 


Xaa Arg Gly Gly Arg Leu Ile Xaa Asn Ser Tyr Arg Ser Pro Gly Gly 
865                 870                 875                 880 


Tyr Lys Gly Phe Asp Xaa Tyr Arg Gly Leu Pro Ser Ile Ser Asn Gly 
                885                 890                 895     


Asn Tyr Ser Gln Leu Gln Phe Gln Ala Arg Glu Tyr Ser Gly Ala Pro 
            900                 905                 910         


Tyr Ser Gln Arg Asp Asn Phe Gln Gln Cys Tyr Lys Arg Gly Gly Xaa 
        915                 920                 925             


Ser Gly Gly Pro Arg Ala Asn Ser Arg Ala Asn Cys Phe Ile Met Arg 
    930                 935                 940                 


Asn Ser Leu Leu Leu Ile Lys Gln Gln Gly Gly Val Ile Leu Leu Arg 
945                 950                 955                 960 


<210> 4941
<211> 1077
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<400> 4941
Met Glu Val Gln Val Ser Gln Ala Ser Leu Gly Phe Glu Leu Xaa Ser 
1               5                   10                  15      


Val Glu Lys Ser Leu Arg Glu Trp Ser Arg Leu Ser Arg Glu Val Ile 
            20                  25                  30          


Ala Trp Leu Cys Pro Ser Ser Pro Asn Phe Ile Leu Asn Phe Pro Pro 
        35                  40                  45              


Pro Pro Ser Ala Ser Ser Val Ser Met Val Gln Leu Phe Ser Ser Pro 
    50                  55                  60                  


Phe Gly Tyr Gln Ser Pro Ser Gly His Ser Glu Glu Glu Arg Glu Gly 
65                  70                  75                  80  


Asn Met Lys Ser Ala Lys Pro Gln Val Asn His Ser Gln His Gly Glu 
                85                  90                  95      


Ser Gln Arg Ala Leu Ser Pro Leu Gln Ser Xaa Leu Ser Ser Ala Ala 
            100                 105                 110         


Ser Pro Ser Gln Ala Tyr Glu Xaa Tyr Ile Glu Asn Gly Leu Ile Cys 
        115                 120                 125             


Leu Lys His Lys Ile Arg Asn Ile Glu Lys Lys Lys Leu Lys Leu Glu 
    130                 135                 140                 


Asp Tyr Lys Asp Arg Leu Lys Ser Gly Glu His Leu Asn Pro Asp Gln 
145                 150                 155                 160 


Leu Glu Ala Val Glu Lys Tyr Glu Glu Val Leu His Asn Leu Glu Phe 
                165                 170                 175     


Ala Lys Glu Leu Gln Lys Xaa Phe Ser Gly Leu Ser Leu Asp Leu Leu 
            180                 185                 190         


Lys Ala Gln Lys Lys Ala Gln Arg Arg Glu His Met Leu Lys Leu Glu 
        195                 200                 205             


Ala Glu Lys Lys Lys Leu Arg Xaa Ile Leu Gln Val Gln Tyr Val Leu 
    210                 215                 220                 


Gln Asn Leu Xaa Gln Glu His Val Gln Lys Asp Phe Lys Gly Gly Leu 
225                 230                 235                 240 


Asn Gly Ala Val Tyr Leu Pro Ser Lys Glu Leu Asp Tyr Leu Ile Lys 
                245                 250                 255     


Phe Ser Lys Leu Xaa Cys Pro Glu Arg Asn Glu Ser Leu Ser Val Glu 
            260                 265                 270         


Asp Gln Met Glu Gln Ser Ser Leu Tyr Phe Trp Asp Leu Leu Glu Gly 
        275                 280                 285             


Ser Glu Lys Ala Val Val Gly Xaa Xaa Tyr Lys His Leu Lys Asp Leu 
    290                 295                 300                 


Leu Ser Lys Leu Leu Asn Ser Gly Tyr Phe Glu Ser Ile Pro Val Pro 
305                 310                 315                 320 


Lys Asn Ala Lys Glu Lys Glu Val Pro Leu Glu Glu Glu Met Leu Ile 
                325                 330                 335     


Gln Ser Glu Lys Lys Xaa Gln Leu Ser Lys Xaa Glu Ser Val Lys Glu 
            340                 345                 350         


Ser Glu Ser Leu Met Glu Phe Ala Gln Pro Glu Ile Gln Pro Gln Glu 
        355                 360                 365             


Phe Leu Asn Arg Arg Tyr Met Xaa Glu Val Asp Tyr Ser Asn Lys Gln 
    370                 375                 380                 


Gly Glu Glu Gln Pro Trp Glu Ala Asp Tyr Ala Arg Lys Pro Asn Leu 
385                 390                 395                 400 


Pro Lys Arg Trp Asp Met Leu Xaa Glu Pro Asp Gly Gln Glu Lys Lys 
                405                 410                 415     


Gln Glu Ser Phe Lys Ser Trp Glu Ala Ser Gly Lys His Gln Glu Val 
            420                 425                 430         


Ser Lys Pro Ala Val Ser Leu Glu Gln Arg Lys Gln Asp Xaa Ser Lys 
        435                 440                 445             


Leu Arg Ser Xaa Leu Pro Glu Glu Gln Lys Lys Gln Glu Ile Ser Lys 
    450                 455                 460                 


Ser Lys Pro Ser Pro Ser Gln Trp Lys Gln Asp Xaa Pro Lys Ser Lys 
465                 470                 475                 480 


Ala Gly Tyr Val Gln Glu Glu Gln Lys Lys Gln Glu Xaa Pro Lys Leu 
                485                 490                 495     


Trp Pro Val Gln Leu Gln Lys Glu Gln Asp Pro Lys Lys Gln Xaa Pro 
            500                 505                 510         


Lys Ser Trp Xaa Pro Ser Met Gln Ser Glu Gln Asn Xaa Xaa Lys Ser 
        515                 520                 525             


Trp Xaa Xaa Pro Met Cys Glu Glu Gln Asp Ser Lys Gln Pro Glu Xaa 
    530                 535                 540                 


Pro Lys Ser Trp Glu Asn Asn Val Glu Ser Gln Lys His Ser Leu Xaa 
545                 550                 555                 560 


Ser Gln Ser Gln Ile Ser Pro Lys Ser Trp Gly Val Ala Xaa Ala Ser 
                565                 570                 575     


Leu Ile Pro Asn Asp Gln Leu Leu Pro Arg Lys Leu Asn Xaa Glu Pro 
            580                 585                 590         


Lys Asp Val Pro Lys Pro Val His Gln Pro Val Gly Ser Ser Ser Xaa 
        595                 600                 605             


Leu Pro Lys Asp Pro Val Leu Arg Lys Glu Lys Leu Gln Asp Leu Met 
    610                 615                 620                 


Xaa Gln Ile Gln Gly Xaa Cys Asn Phe Met Gln Glu Ser Val Leu Asp 
625                 630                 635                 640 


Phe Asp Lys Pro Ser Ser Ala Ile Pro Xaa Ser Gln Pro Pro Ser Ala 
                645                 650                 655     


Xaa Pro Gly Ser Pro Val Ala Ser Lys Glu Gln Asn Leu Ser Ser Gln 
            660                 665                 670         


Ser Asp Phe Leu Gln Glu Pro Leu Gln Ala Xaa Ser Ser Pro Val Xaa 
        675                 680                 685             


Cys Ser Ser Asn Ala Cys Leu Val Xaa Xaa Asp Gln Ala Ser Ser Gly 
    690                 695                 700                 


Ser Glu Xaa Glu Phe Met Xaa Ser Glu Xaa Pro Glu Val Phe Asn Val 
705                 710                 715                 720 


Asn Ala Pro Leu Pro Pro Arg Lys Glu Gln Glu Ile Lys Glu Ser Pro 
                725                 730                 735     


Tyr Ser Pro Gly Tyr Asn Gln Ser Phe Xaa Xaa Ala Ser Xaa Gln Xaa 
            740                 745                 750         


Pro Pro Gln Cys Gln Leu Pro Ser Ile His Val Glu Gln Xaa Val His 
        755                 760                 765             


Ser Gln Glu Xaa Ala Asn Tyr His Pro Asp Gly Xaa Ile Gln Val Ser 
    770                 775                 780                 


Asn Gly Ser Leu Ala Phe Tyr Pro Ala Gln Xaa Asn Val Phe Pro Arg 
785                 790                 795                 800 


Pro Xaa Gln Pro Phe Val Asn Ser Arg Gly Ser Val Arg Gly Cys Xaa 
                805                 810                 815     


Arg Gly Gly Arg Leu Ile Xaa Asn Ser Tyr Arg Ser Pro Gly Gly Tyr 
            820                 825                 830         


Lys Gly Phe Asp Xaa Tyr Arg Gly Leu Pro Ser Ile Ser Asn Gly Asn 
        835                 840                 845             


Tyr Ser Gln Leu Gln Phe Gln Ala Arg Glu Tyr Ser Gly Ala Pro Tyr 
    850                 855                 860                 


Ser Gln Arg Asp Asn Phe Gln Gln Cys Tyr Lys Arg Gly Gly Xaa Ser 
865                 870                 875                 880 


Gly Gly Pro Arg Ala Asn Ser Arg Ala Gly Trp Ser Asp Ser Ser Gln 
                885                 890                 895     


Val Ser Ser Pro Glu Arg Asp Asn Glu Xaa Phe Asn Ser Gly Asp Ser 
            900                 905                 910         


Gly Gln Gly Asp Ser Arg Ser Met Xaa Pro Val Asp Val Pro Val Xaa 
        915                 920                 925             


Asn Pro Ala Ala Xaa Ile Leu Pro Val His Val Tyr Pro Leu Pro Gln 
    930                 935                 940                 


Gln Met Arg Val Ala Phe Ser Ala Ala Arg Xaa Ser Asn Leu Ala Pro 
945                 950                 955                 960 


Gly Xaa Leu Asp Gln Pro Ile Val Phe Asp Leu Leu Leu Asn Asn Leu 
                965                 970                 975     


Gly Glu Xaa Phe Asp Leu Gln Leu Gly Arg Phe Asn Cys Pro Val Asn 
            980                 985                 990         


Gly Xaa Tyr Val Phe Ile Phe His  Met Leu Lys Leu Ala  Val Asn Val 
        995                 1000                 1005             


Pro Leu  Tyr Val Asn Leu Met  Lys Asn Glu Glu Val  Leu Val Ser 
    1010                 1015                 1020             


Ala Tyr  Ala Asn Asp Gly Ala  Pro Asp His Glu Xaa  Ala Ser Asn 
    1025                 1030                 1035             


His Ala  Ile Leu Gln Leu Phe  Gln Gly Asp Gln Ile  Trp Leu Arg 
    1040                 1045                 1050             


Leu His  Arg Gly Ala Ile Tyr  Gly Ser Ser Trp Lys  Tyr Ser Xaa 
    1055                 1060                 1065             


Phe Ser  Gly Tyr Leu Leu Tyr  Gln Asp 
    1070                 1075         


<210> 4942
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<400> 4942
Met Lys Ser Ala Lys Pro Gln Val Asn His Ser Gln His Gly Glu Ser 
1               5                   10                  15      


Gln Arg Ala Leu Ser Pro Leu Gln Ser Xaa Leu Ser Ser Ala Ala Ser 
            20                  25                  30          


Pro Ser Gln Ala Tyr Glu Xaa Tyr Ile Glu Asn Gly Leu Ile Cys Leu 
        35                  40                  45              


Lys His Lys Ile Arg Asn Ile Glu Lys Lys Lys Leu Lys Leu Glu Asp 
    50                  55                  60                  


Tyr Lys Asp Arg Leu Lys Ser Gly Glu His Leu Asn Pro Asp Gln Leu 
65                  70                  75                  80  


Glu Ala Val Glu Lys Tyr Glu Glu Val Leu His Asn Leu Glu Phe Ala 
                85                  90                  95      


Lys Glu Leu Gln Lys Xaa Phe Ser Gly Leu Ser Leu Asp Leu Leu Lys 
            100                 105                 110         


Ala Gln Lys Lys Ala Gln Arg 
        115                 


<210> 4943
<211> 126
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<400> 4943
Met Lys Ser Ala Lys Pro Gln Val Asn His Ser Gln His Gly Glu Ser 
1               5                   10                  15      


Gln Arg Ala Leu Ser Pro Leu Gln Ser Xaa Leu Ser Ser Ala Ala Ser 
            20                  25                  30          


Pro Ser Gln Ala Tyr Glu Xaa Tyr Ile Glu Asn Gly Leu Ile Cys Leu 
        35                  40                  45              


Lys His Lys Ile Arg Asn Ile Glu Lys Lys Lys Leu Lys Leu Glu Asp 
    50                  55                  60                  


Tyr Lys Asp Arg Leu Lys Ser Gly Glu His Leu Asn Pro Asp Gln Leu 
65                  70                  75                  80  


Glu Ala Val Glu Lys Tyr Glu Glu Val Leu His Asn Leu Glu Phe Ala 
                85                  90                  95      


Lys Glu Leu Gln Lys Xaa Phe Ser Gly Leu Ser Leu Asp Leu Leu Lys 
            100                 105                 110         


Ala Gln Lys Lys Ala Gln Arg Arg Glu His Met Leu Lys Leu 
        115                 120                 125     


<210> 4944
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<400> 4944
Met Lys Ser Ala Lys Pro Gln Val Asn His Ser Gln His Gly Glu Ser 
1               5                   10                  15      


Gln Arg Ala Leu Ser Pro Leu Gln Ser Xaa Leu Ser Ser Ala Ala Ser 
            20                  25                  30          


Pro Ser Gln Ala Tyr Glu Xaa Tyr Ile Glu Asn Gly Leu Ile Cys Leu 
        35                  40                  45              


Lys His Lys Ile Arg Asn Ile Glu Lys Lys Lys Leu Lys Leu Glu Asp 
    50                  55                  60                  


Tyr Lys Asp Arg Leu Lys Ser Gly Glu His Leu Asn Pro Asp Gln Leu 
65                  70                  75                  80  


Glu Ala Val Glu Lys Tyr Glu Glu Val Leu His Asn Leu Glu Phe Ala 
                85                  90                  95      


Lys Glu Leu Gln Lys Xaa Phe Ser Gly Leu Ser Leu Asp Leu Leu Lys 
            100                 105                 110         


Ala Gln Lys Lys Ala Gln Arg Arg Glu His Met Leu Lys Leu Glu Ala 
        115                 120                 125             


Glu Lys Lys Lys Leu Arg Xaa Ile Leu Gln Val Gln Tyr Val Leu Gln 
    130                 135                 140                 


Asn Leu Xaa Gln Glu His Val Gln Lys Asp Phe Lys Gly Gly Leu Asn 
145                 150                 155                 160 


Gly Ala Val Tyr Leu Pro Ser Lys Glu Leu Asp Tyr Leu Ile Lys Phe 
                165                 170                 175     


Ser Lys Leu Xaa Cys Pro Glu Arg Asn Glu 
            180                 185     


<210> 4945
<211> 702
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<400> 4945
Met Lys Ser Ala Lys Pro Gln Val Asn His Ser Gln His Gly Glu Ser 
1               5                   10                  15      


Gln Arg Ala Leu Ser Pro Leu Gln Ser Xaa Leu Ser Ser Ala Ala Ser 
            20                  25                  30          


Pro Ser Gln Ala Tyr Glu Xaa Tyr Ile Glu Asn Gly Leu Ile Cys Leu 
        35                  40                  45              


Lys His Lys Ile Arg Asn Ile Glu Lys Lys Lys Leu Lys Leu Glu Asp 
    50                  55                  60                  


Tyr Lys Asp Arg Leu Lys Ser Gly Glu His Leu Asn Pro Asp Gln Leu 
65                  70                  75                  80  


Glu Ala Val Glu Lys Tyr Glu Glu Val Leu His Asn Leu Glu Phe Ala 
                85                  90                  95      


Lys Glu Leu Gln Lys Xaa Phe Ser Gly Leu Ser Leu Asp Leu Leu Lys 
            100                 105                 110         


Ala Gln Lys Lys Ala Gln Arg Arg Glu His Met Leu Lys Leu Glu Ala 
        115                 120                 125             


Glu Lys Lys Lys Leu Arg Xaa Ile Leu Gln Val Gln Tyr Val Leu Gln 
    130                 135                 140                 


Asn Leu Xaa Gln Glu His Val Gln Lys Asp Phe Lys Gly Gly Leu Asn 
145                 150                 155                 160 


Gly Ala Val Tyr Leu Pro Ser Lys Glu Leu Asp Tyr Leu Ile Lys Phe 
                165                 170                 175     


Ser Lys Leu Xaa Cys Pro Glu Arg Asn Glu Ser Leu Ser Val Glu Asp 
            180                 185                 190         


Gln Met Glu Gln Ser Ser Leu Tyr Phe Trp Asp Leu Leu Glu Gly Ser 
        195                 200                 205             


Glu Lys Ala Val Val Gly Xaa Xaa Tyr Lys His Leu Lys Asp Leu Leu 
    210                 215                 220                 


Ser Lys Leu Leu Asn Ser Gly Tyr Phe Glu Ser Ile Pro Val Pro Lys 
225                 230                 235                 240 


Asn Ala Lys Glu Lys Glu Val Pro Leu Glu Glu Glu Met Leu Ile Gln 
                245                 250                 255     


Ser Glu Lys Lys Xaa Gln Leu Ser Lys Xaa Glu Ser Val Lys Glu Ser 
            260                 265                 270         


Glu Ser Leu Met Glu Phe Ala Gln Pro Glu Ile Gln Pro Gln Glu Phe 
        275                 280                 285             


Leu Asn Arg Arg Tyr Met Xaa Glu Val Asp Tyr Ser Asn Lys Gln Gly 
    290                 295                 300                 


Glu Glu Gln Pro Trp Glu Ala Asp Tyr Ala Arg Lys Pro Asn Leu Pro 
305                 310                 315                 320 


Lys Arg Trp Asp Met Leu Xaa Glu Pro Asp Gly Gln Glu Lys Lys Gln 
                325                 330                 335     


Glu Ser Phe Lys Ser Trp Glu Ala Ser Gly Lys His Gln Glu Val Ser 
            340                 345                 350         


Lys Pro Ala Val Ser Leu Glu Gln Arg Lys Gln Asp Xaa Ser Lys Leu 
        355                 360                 365             


Arg Ser Xaa Leu Pro Glu Glu Gln Lys Lys Gln Glu Ile Ser Lys Ser 
    370                 375                 380                 


Lys Pro Ser Pro Ser Gln Trp Lys Gln Asp Xaa Pro Lys Ser Lys Ala 
385                 390                 395                 400 


Gly Tyr Val Gln Glu Glu Gln Lys Lys Gln Glu Xaa Pro Lys Leu Trp 
                405                 410                 415     


Pro Val Gln Leu Gln Lys Glu Gln Asp Pro Lys Lys Gln Xaa Pro Lys 
            420                 425                 430         


Ser Trp Xaa Pro Ser Met Gln Ser Glu Gln Asn Xaa Xaa Lys Ser Trp 
        435                 440                 445             


Xaa Xaa Pro Met Cys Glu Glu Gln Asp Ser Lys Gln Pro Glu Xaa Pro 
    450                 455                 460                 


Lys Ser Trp Glu Asn Asn Val Glu Ser Gln Lys His Ser Leu Xaa Ser 
465                 470                 475                 480 


Gln Ser Gln Ile Ser Pro Lys Ser Trp Gly Val Ala Xaa Ala Ser Leu 
                485                 490                 495     


Ile Pro Asn Asp Gln Leu Leu Pro Arg Lys Leu Asn Xaa Glu Pro Lys 
            500                 505                 510         


Asp Val Pro Lys Pro Val His Gln Pro Val Gly Ser Ser Ser Xaa Leu 
        515                 520                 525             


Pro Lys Asp Pro Val Leu Arg Lys Glu Lys Leu Gln Asp Leu Met Xaa 
    530                 535                 540                 


Gln Ile Gln Gly Xaa Cys Asn Phe Met Gln Glu Ser Val Leu Asp Phe 
545                 550                 555                 560 


Asp Lys Pro Ser Ser Ala Ile Pro Xaa Ser Gln Pro Pro Ser Ala Xaa 
                565                 570                 575     


Pro Gly Ser Pro Val Ala Ser Lys Glu Gln Asn Leu Ser Ser Gln Ser 
            580                 585                 590         


Asp Phe Leu Gln Glu Pro Leu Gln Ala Xaa Ser Ser Pro Val Xaa Cys 
        595                 600                 605             


Ser Ser Asn Ala Cys Leu Val Xaa Xaa Asp Gln Ala Ser Ser Gly Ser 
    610                 615                 620                 


Glu Xaa Glu Phe Met Xaa Ser Glu Xaa Pro Glu Ala Ala Ile Pro Pro 
625                 630                 635                 640 


Gly Lys Gln Pro Ser Ser Leu Ala Ser Pro Asn Pro Pro Met Ala Lys 
                645                 650                 655     


Gly Ser Glu Gln Gly Phe Gln Ser Pro Pro Ala Ser Ser Ser Ser Val 
            660                 665                 670         


Xaa Ile Asn Xaa Ala Pro Phe Gln Ala Met Gln Xaa Val Phe Asn Val 
        675                 680                 685             


Asn Ala Pro Leu Pro Pro Arg Lys Glu Gln Glu Ile Lys Glu 
    690                 695                 700         


<210> 4946
<211> 68
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<400> 4946
Met Leu Lys Leu Glu Ala Glu Lys Lys Lys Leu Arg Xaa Ile Leu Gln 
1               5                   10                  15      


Val Gln Tyr Val Leu Gln Asn Leu Xaa Gln Glu His Val Gln Lys Asp 
            20                  25                  30          


Phe Lys Gly Gly Leu Asn Gly Ala Val Tyr Leu Pro Ser Lys Glu Leu 
        35                  40                  45              


Asp Tyr Leu Ile Lys Phe Ser Lys Leu Xaa Cys Pro Glu Arg Asn Glu 
    50                  55                  60                  


Ser Leu Ser Val 
65              


<210> 4947
<211> 84
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<400> 4947
Met Leu Lys Leu Glu Ala Glu Lys Lys Lys Leu Arg Xaa Ile Leu Gln 
1               5                   10                  15      


Val Gln Tyr Val Leu Gln Asn Leu Xaa Gln Glu His Val Gln Lys Asp 
            20                  25                  30          


Phe Lys Gly Gly Leu Asn Gly Ala Val Tyr Leu Pro Ser Lys Glu Leu 
        35                  40                  45              


Asp Tyr Leu Ile Lys Phe Ser Lys Leu Xaa Cys Pro Glu Arg Asn Glu 
    50                  55                  60                  


Ser Leu Ser Val Glu Asp Gln Met Glu Gln Ser Ser Leu Tyr Phe Trp 
65                  70                  75                  80  


Asp Leu Leu Glu 
                


<210> 4948
<211> 174
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<400> 4948
Xaa Cys Pro Ser Ser Pro Asn Phe Ile Leu Asn Phe Pro Pro Pro Pro 
1               5                   10                  15      


Ser Ala Ser Ser Val Ser Met Val Gln Leu Phe Ser Ser Pro Phe Gly 
            20                  25                  30          


Tyr Gln Ser Pro Ser Gly His Ser Glu Glu Glu Arg Glu Gly Asn Met 
        35                  40                  45              


Lys Ser Ala Lys Pro Gln Val Asn His Ser Gln His Gly Glu Ser Gln 
    50                  55                  60                  


Arg Ala Leu Ser Pro Leu Gln Ser Xaa Leu Ser Ser Ala Ala Ser Pro 
65                  70                  75                  80  


Ser Gln Ala Tyr Glu Xaa Tyr Ile Glu Asn Gly Leu Ile Cys Leu Lys 
                85                  90                  95      


His Lys Ile Arg Asn Ile Glu Lys Lys Lys Leu Lys Leu Glu Asp Tyr 
            100                 105                 110         


Lys Asp Arg Leu Lys Ser Gly Glu His Leu Asn Pro Asp Gln Leu Glu 
        115                 120                 125             


Ala Val Glu Lys Tyr Glu Glu Val Leu His Asn Leu Glu Phe Ala Lys 
    130                 135                 140                 


Glu Leu Gln Lys Xaa Phe Ser Gly Leu Ser Leu Asp Val Xaa Xaa Lys 
145                 150                 155                 160 


Ser Ala Lys Glu Gly Pro Glu Lys Gly Ala His Ala Lys Xaa 
                165                 170                 


<210> 4949
<211> 134
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<400> 4949
Met Asp Ala Val Asp Ala Xaa Met Glu Lys Leu Arg Ala Gln Cys Leu 
1               5                   10                  15      


Ser Arg Gly Ala Ser Gly Ile Gln Gly Leu Ala Arg Phe Phe Arg Gln 
            20                  25                  30          


Leu Asp Arg Asp Gly Ser Arg Ser Leu Asp Ala Asp Glu Phe Arg Gln 
        35                  40                  45              


Gly Leu Ala Lys Leu Gly Leu Val Leu Asp Gln Ala Glu Ala Glu Gly 
    50                  55                  60                  


Val Cys Arg Lys Trp Asp Arg Asn Gly Ser Gly Xaa Leu Asp Leu Glu 
65                  70                  75                  80  


Glu Phe Leu Arg Ala Leu Arg Pro Pro Met Ser Gln Ala Arg Glu Ala 
                85                  90                  95      


Val Ile Ala Ala Ala Phe Ala Lys Leu Asp Arg Ser Gly Asp Gly Val 
            100                 105                 110         


Val Xaa Val Asp Asp Leu Arg Gly Val Tyr Ser Gly Arg Ala His Pro 
        115                 120                 125             


Lys Val Arg Ser Gly Glu 
    130                 


<210> 4950
<211> 189
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<400> 4950
Met Asp Ala Val Asp Ala Xaa Met Glu Lys Leu Arg Ala Gln Cys Leu 
1               5                   10                  15      


Ser Arg Gly Ala Ser Gly Ile Gln Gly Leu Ala Arg Phe Phe Arg Gln 
            20                  25                  30          


Leu Asp Arg Asp Gly Ser Arg Ser Leu Asp Ala Asp Glu Phe Arg Gln 
        35                  40                  45              


Gly Leu Ala Lys Leu Gly Leu Val Leu Asp Gln Ala Glu Ala Glu Gly 
    50                  55                  60                  


Val Cys Arg Lys Trp Asp Arg Asn Gly Ser Gly Xaa Leu Asp Leu Glu 
65                  70                  75                  80  


Glu Phe Leu Arg Ala Leu Arg Pro Pro Met Ser Gln Ala Arg Glu Ala 
                85                  90                  95      


Val Ile Ala Ala Ala Phe Ala Lys Leu Asp Arg Ser Gly Asp Gly Val 
            100                 105                 110         


Val Xaa Val Asp Asp Leu Arg Gly Val Tyr Ser Gly Arg Ala His Pro 
        115                 120                 125             


Lys Val Arg Ser Gly Glu Trp Xaa Glu Asp Glu Val Leu Arg Arg Phe 
    130                 135                 140                 


Leu Asp Asn Phe Asp Ser Ser Glu Lys Asp Gly Gln Val Xaa Leu Ala 
145                 150                 155                 160 


Glu Phe Gln Asp Tyr Tyr Ser Gly Val Ser Ala Ser Met Asn Xaa Asp 
                165                 170                 175     


Glu Glu Phe Val Ala Met Met Xaa Ser Ala Trp Gln Leu 
            180                 185                 


<210> 4951
<211> 162
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<400> 4951
Met Asp Ala Val Asp Ala Xaa Met Glu Lys Leu Arg Ala Gln Cys Leu 
1               5                   10                  15      


Ser Arg Gly Ala Ser Gly Ile Gln Gly Leu Ala Arg Phe Phe Arg Gln 
            20                  25                  30          


Leu Asp Arg Asp Gly Ser Arg Ser Leu Asp Ala Asp Glu Phe Arg Gln 
        35                  40                  45              


Gly Leu Ala Lys Leu Gly Leu Val Leu Asp Gln Ala Glu Ala Glu Gly 
    50                  55                  60                  


Val Cys Arg Lys Trp Asp Arg Asn Gly Ser Gly Xaa Leu Asp Leu Glu 
65                  70                  75                  80  


Glu Phe Leu Arg Ala Leu Arg Pro Pro Met Ser Gln Ala Arg Glu Ala 
                85                  90                  95      


Val Ile Ala Ala Ala Phe Ala Lys Leu Asp Arg Ser Gly Asp Gly Val 
            100                 105                 110         


Val Xaa Val Asp Asp Leu Arg Gly Val Tyr Ser Gly Arg Ala His Pro 
        115                 120                 125             


Lys Val Xaa Leu Ala Glu Phe Gln Asp Tyr Tyr Ser Gly Val Ser Ala 
    130                 135                 140                 


Ser Met Asn Xaa Asp Glu Glu Phe Val Ala Met Met Xaa Ser Ala Trp 
145                 150                 155                 160 


Gln Leu 
        


<210> 4952
<211> 275
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<400> 4952
Met Gln Cys His Arg Asp Leu Ala Leu Ser Gln Ala Leu Trp Gly Trp 
1               5                   10                  15      


Gln Leu Ser Lys Gln Ser Gly Trp Ala His Pro Ser Leu Pro His Ser 
            20                  25                  30          


Pro Leu Pro Ser Xaa Val His Ser Cys Ser Trp Ala Pro Pro His Leu 
        35                  40                  45              


Gln Arg His Leu Pro Leu Ala Xaa Val Ser Pro Gly Xaa Xaa Gln Leu 
    50                  55                  60                  


Xaa Gln Gly Pro Ala Gly Arg Xaa Leu Gly Gln Xaa Gln Ala Ser Cys 
65                  70                  75                  80  


Pro Glu Pro Arg Pro Ser Met Asp Ala Val Asp Ala Xaa Met Glu Lys 
                85                  90                  95      


Leu Arg Ala Gln Cys Leu Ser Arg Gly Ala Ser Gly Ile Gln Gly Leu 
            100                 105                 110         


Ala Arg Phe Phe Arg Gln Leu Asp Arg Asp Gly Ser Arg Ser Leu Asp 
        115                 120                 125             


Ala Asp Glu Phe Arg Gln Gly Leu Ala Lys Leu Gly Leu Val Leu Asp 
    130                 135                 140                 


Gln Ala Glu Ala Glu Gly Val Cys Arg Lys Trp Asp Arg Asn Gly Ser 
145                 150                 155                 160 


Gly Xaa Leu Asp Leu Glu Glu Phe Leu Arg Ala Leu Arg Pro Pro Met 
                165                 170                 175     


Ser Gln Ala Arg Glu Ala Val Ile Ala Ala Ala Phe Ala Lys Leu Asp 
            180                 185                 190         


Arg Ser Gly Asp Gly Val Val Xaa Val Asp Asp Leu Arg Gly Val Tyr 
        195                 200                 205             


Ser Gly Arg Ala His Pro Lys Val Arg Ser Gly Glu Trp Xaa Glu Asp 
    210                 215                 220                 


Glu Val Leu Arg Arg Phe Leu Asp Asn Phe Asp Ser Ser Glu Lys Asp 
225                 230                 235                 240 


Gly Gln Val Xaa Leu Ala Glu Phe Gln Asp Tyr Tyr Ser Gly Val Ser 
                245                 250                 255     


Ala Ser Met Asn Xaa Asp Glu Glu Phe Val Ala Met Met Xaa Ser Ala 
            260                 265                 270         


Trp Gln Leu 
        275 


<210> 4953
<211> 248
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<400> 4953
Met Gln Cys His Arg Asp Leu Ala Leu Ser Gln Ala Leu Trp Gly Trp 
1               5                   10                  15      


Gln Leu Ser Lys Gln Ser Gly Trp Ala His Pro Ser Leu Pro His Ser 
            20                  25                  30          


Pro Leu Pro Ser Xaa Val His Ser Cys Ser Trp Ala Pro Pro His Leu 
        35                  40                  45              


Gln Arg His Leu Pro Leu Ala Xaa Val Ser Pro Gly Xaa Xaa Gln Leu 
    50                  55                  60                  


Xaa Gln Gly Pro Ala Gly Arg Xaa Leu Gly Gln Xaa Gln Ala Ser Cys 
65                  70                  75                  80  


Pro Glu Pro Arg Pro Ser Met Asp Ala Val Asp Ala Xaa Met Glu Lys 
                85                  90                  95      


Leu Arg Ala Gln Cys Leu Ser Arg Gly Ala Ser Gly Ile Gln Gly Leu 
            100                 105                 110         


Ala Arg Phe Phe Arg Gln Leu Asp Arg Asp Gly Ser Arg Ser Leu Asp 
        115                 120                 125             


Ala Asp Glu Phe Arg Gln Gly Leu Ala Lys Leu Gly Leu Val Leu Asp 
    130                 135                 140                 


Gln Ala Glu Ala Glu Gly Val Cys Arg Lys Trp Asp Arg Asn Gly Ser 
145                 150                 155                 160 


Gly Xaa Leu Asp Leu Glu Glu Phe Leu Arg Ala Leu Arg Pro Pro Met 
                165                 170                 175     


Ser Gln Ala Arg Glu Ala Val Ile Ala Ala Ala Phe Ala Lys Leu Asp 
            180                 185                 190         


Arg Ser Gly Asp Gly Val Val Xaa Val Asp Asp Leu Arg Gly Val Tyr 
        195                 200                 205             


Ser Gly Arg Ala His Pro Lys Val Xaa Leu Ala Glu Phe Gln Asp Tyr 
    210                 215                 220                 


Tyr Ser Gly Val Ser Ala Ser Met Asn Xaa Asp Glu Glu Phe Val Ala 
225                 230                 235                 240 


Met Met Xaa Ser Ala Trp Gln Leu 
                245             


<210> 4954
<211> 301
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<400> 4954
Met His Pro Ser Arg Arg Ser Leu Pro Phe Pro Leu Asn Cys Gln Leu 
1               5                   10                  15      


Ala Arg Val Gly Xaa Ala Asp Tyr Gly Ser Pro Ser Asp Gln Ser Asp 
            20                  25                  30          


Gln Gln Leu Asp Cys Ala Leu Asp Leu Met Arg Arg Leu Pro Pro Gln 
        35                  40                  45              


Gln Ile Glu Lys Asn Leu Ser Asp Leu Ile Asp Leu Val Pro Ser Leu 
    50                  55                  60                  


Cys Glu Asp Leu Leu Ser Ser Val Asp Gln Pro Leu Lys Ile Ala Arg 
65                  70                  75                  80  


Asp Lys Val Val Gly Lys Asp Tyr Leu Leu Cys Asp Tyr Asn Arg Asp 
                85                  90                  95      


Gly Asp Ser Tyr Arg Ser Pro Trp Ser Asn Lys Tyr Asp Pro Pro Leu 
            100                 105                 110         


Glu Asp Gly Ala Met Pro Ser Ala Arg Leu Arg Lys Leu Glu Val Glu 
        115                 120                 125             


Ala Asn Asn Ala Phe Asp Gln Tyr Arg Asp Leu Tyr Phe Glu Gly Gly 
    130                 135                 140                 


Val Ser Ser Val Tyr Leu Trp Asp Leu Asp His Gly Phe Ala Gly Val 
145                 150                 155                 160 


Ile Leu Ile Lys Lys Ala Gly Asp Gly Ser Lys Lys Ile Lys Gly Cys 
                165                 170                 175     


Trp Asp Ser Ile His Val Val Glu Val Gln Glu Lys Ser Ser Gly Arg 
            180                 185                 190         


Xaa Ala His Tyr Lys Leu Xaa Ser Xaa Val Met Leu Trp Leu Gln Xaa 
        195                 200                 205             


Asn Lys Ser Gly Ser Gly Xaa Met Asn Leu Gly Gly Ser Leu Xaa Arg 
    210                 215                 220                 


Gln Met Glu Lys Asp Glu Xaa Val Ser Asp Cys Ser Pro His Ile Ala 
225                 230                 235                 240 


Asn Ile Gly Arg Leu Val Glu Asp Met Glu Asn Lys Ile Arg Ser Xaa 
                245                 250                 255     


Leu Asn Glu Ile Tyr Phe Gly Lys Xaa Lys Asp Ile Val Asn Gly Leu 
            260                 265                 270         


Arg Ser Val Gln Xaa Phe Ala Asp Lys Ser Lys Gln Glu Ala Leu Lys 
        275                 280                 285             


Asn Asp Leu Val Glu Ala Leu Lys Arg Lys Gln Gln Cys 
    290                 295                 300     


<210> 4955
<211> 260
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<400> 4955
Met Pro Arg Gln Phe Gln Asp Xaa Gly Phe Ser Arg Pro Gly Leu Gly 
1               5                   10                  15      


Gln Pro Arg Arg Cys Asp Pro Glu Pro Arg Lys Ser Asp Gln Gln Leu 
            20                  25                  30          


Asp Cys Ala Leu Asp Leu Met Arg Arg Leu Pro Pro Gln Gln Ile Glu 
        35                  40                  45              


Lys Asn Leu Ser Asp Leu Ile Asp Leu Val Pro Ser Leu Cys Glu Asp 
    50                  55                  60                  


Leu Leu Ser Ser Val Asp Gln Pro Leu Lys Ile Ala Arg Asp Lys Val 
65                  70                  75                  80  


Val Gly Lys Asp Tyr Leu Leu Cys Asp Tyr Asn Arg Asp Gly Asp Ser 
                85                  90                  95      


Tyr Arg Ser Pro Trp Ser Asn Lys Tyr Asp Pro Pro Leu Glu Asp Gly 
            100                 105                 110         


Ala Met Pro Ser Ala Arg Leu Arg Lys Leu Glu Val Glu Ala Asn Asn 
        115                 120                 125             


Ala Phe Asp Gln Tyr Arg Asp Leu Tyr Phe Glu Gly Gly Val Ser Ser 
    130                 135                 140                 


Val Tyr Leu Trp Asp Leu Asp His Gly Phe Ala Gly Val Ile Leu Ile 
145                 150                 155                 160 


Lys Lys Ala Gly Asp Gly Ser Lys Lys Ile Lys Gly Cys Trp Asp Ser 
                165                 170                 175     


Ile His Val Val Glu Val Gln Glu Lys Ser Ser Gly Arg Xaa Ala His 
            180                 185                 190         


Tyr Lys Leu Xaa Ser Xaa Val Met Leu Trp Leu Gln Xaa Asn Lys Ser 
        195                 200                 205             


Gly Ser Gly Xaa Met Asn Leu Gly Gly Ser Leu Xaa Arg Gln Met Glu 
    210                 215                 220                 


Lys Asp Glu Xaa Val Ser Asp Cys Ser Pro His Ile Ala Asn Ile Gly 
225                 230                 235                 240 


Arg Leu Val Glu Val Cys Ala Asp Phe Cys Arg Gln Ile Lys Xaa Arg 
                245                 250                 255     


Ser Ser Glu Glu 
            260 


<210> 4956
<211> 260
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<400> 4956
Met Arg Arg Leu Pro Pro Gln Gln Ile Glu Lys Asn Leu Ser Asp Leu 
1               5                   10                  15      


Ile Asp Leu Val Pro Ser Leu Cys Glu Asp Leu Leu Ser Ser Val Asp 
            20                  25                  30          


Gln Pro Leu Lys Ile Ala Arg Asp Lys Val Val Gly Lys Asp Tyr Leu 
        35                  40                  45              


Leu Cys Asp Tyr Asn Arg Asp Gly Asp Ser Tyr Arg Ser Pro Trp Ser 
    50                  55                  60                  


Asn Lys Tyr Asp Pro Pro Leu Glu Asp Gly Ala Met Pro Ser Ala Arg 
65                  70                  75                  80  


Leu Arg Lys Leu Glu Val Glu Ala Asn Asn Ala Phe Asp Gln Tyr Arg 
                85                  90                  95      


Asp Leu Tyr Phe Glu Gly Gly Val Ser Ser Val Tyr Leu Trp Asp Leu 
            100                 105                 110         


Asp His Gly Phe Ala Gly Val Ile Leu Ile Lys Lys Ala Gly Asp Gly 
        115                 120                 125             


Ser Lys Lys Ile Lys Gly Cys Trp Asp Ser Ile His Val Val Glu Val 
    130                 135                 140                 


Gln Glu Lys Ser Ser Gly Arg Xaa Ala His Tyr Lys Leu Xaa Ser Xaa 
145                 150                 155                 160 


Val Met Leu Trp Leu Gln Xaa Asn Lys Ser Gly Ser Gly Xaa Met Asn 
                165                 170                 175     


Leu Gly Gly Ser Leu Xaa Arg Gln Met Glu Lys Asp Glu Xaa Val Ser 
            180                 185                 190         


Asp Cys Ser Pro His Ile Ala Asn Ile Gly Arg Leu Val Glu Asp Met 
        195                 200                 205             


Glu Asn Lys Ile Arg Ser Xaa Leu Asn Glu Ile Tyr Phe Gly Lys Xaa 
    210                 215                 220                 


Lys Asp Ile Val Asn Gly Leu Arg Ser Val Gln Xaa Phe Ala Asp Lys 
225                 230                 235                 240 


Ser Lys Gln Glu Ala Leu Lys Asn Asp Leu Val Glu Ala Leu Lys Arg 
                245                 250                 255     


Lys Gln Gln Cys 
            260 


<210> 4957
<211> 277
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<400> 4957
Met Ser Asp Gln Gln Leu Asp Cys Ala Leu Asp Leu Met Arg Arg Leu 
1               5                   10                  15      


Pro Pro Gln Gln Ile Glu Lys Asn Leu Ser Asp Leu Ile Asp Leu Val 
            20                  25                  30          


Pro Ser Leu Cys Glu Asp Leu Leu Ser Ser Val Asp Gln Pro Leu Lys 
        35                  40                  45              


Ile Ala Arg Asp Lys Val Val Gly Lys Asp Tyr Leu Leu Cys Asp Tyr 
    50                  55                  60                  


Asn Arg Asp Gly Asp Ser Tyr Arg Ser Pro Trp Ser Asn Lys Tyr Asp 
65                  70                  75                  80  


Pro Pro Leu Glu Asp Gly Ala Met Pro Ser Ala Arg Leu Arg Lys Leu 
                85                  90                  95      


Glu Val Glu Ala Asn Asn Ala Phe Asp Gln Tyr Arg Asp Leu Tyr Phe 
            100                 105                 110         


Glu Gly Gly Val Ser Ser Val Tyr Leu Trp Asp Leu Asp His Gly Phe 
        115                 120                 125             


Ala Gly Val Ile Leu Ile Lys Lys Ala Gly Asp Gly Ser Lys Lys Ile 
    130                 135                 140                 


Lys Gly Cys Trp Asp Ser Ile His Val Val Glu Val Gln Glu Lys Ser 
145                 150                 155                 160 


Ser Gly Arg Xaa Ala His Tyr Lys Leu Xaa Ser Xaa Val Met Leu Trp 
                165                 170                 175     


Leu Gln Xaa Asn Lys Ser Gly Ser Gly Xaa Met Asn Leu Gly Gly Ser 
            180                 185                 190         


Leu Xaa Arg Gln Met Glu Lys Asp Glu Xaa Val Ser Asp Cys Ser Pro 
        195                 200                 205             


His Ile Ala Asn Ile Gly Arg Leu Val Glu Asp Met Glu Asn Lys Ile 
    210                 215                 220                 


Arg Ser Xaa Leu Asn Glu Ile Tyr Phe Gly Lys Xaa Lys Asp Ile Val 
225                 230                 235                 240 


Asn Gly Leu Arg Ser Ile Asp Ala Ile Pro Asp Asn Gln Lys Phe Lys 
                245                 250                 255     


Gln Leu Gln Arg Glu Leu Ser Gln Val Leu Xaa Gln Arg Gln Ile Tyr 
            260                 265                 270         


Ile Gln Pro Asp Asn 
        275         


<210> 4958
<211> 272
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<400> 4958
Met Ser Asp Gln Gln Leu Asp Cys Ala Leu Asp Leu Met Arg Arg Leu 
1               5                   10                  15      


Pro Pro Gln Gln Ile Glu Lys Asn Leu Ser Asp Leu Ile Asp Leu Val 
            20                  25                  30          


Pro Ser Leu Cys Glu Asp Leu Leu Ser Ser Val Asp Gln Pro Leu Lys 
        35                  40                  45              


Ile Ala Arg Asp Lys Val Val Gly Lys Asp Tyr Leu Leu Cys Asp Tyr 
    50                  55                  60                  


Asn Arg Asp Gly Asp Ser Tyr Arg Ser Pro Trp Ser Asn Lys Tyr Asp 
65                  70                  75                  80  


Pro Pro Leu Glu Asp Gly Ala Met Pro Ser Ala Arg Leu Arg Lys Leu 
                85                  90                  95      


Glu Val Glu Ala Asn Asn Ala Phe Asp Gln Tyr Arg Asp Leu Tyr Phe 
            100                 105                 110         


Glu Gly Gly Val Ser Ser Val Tyr Leu Trp Asp Leu Asp His Gly Phe 
        115                 120                 125             


Ala Gly Val Ile Leu Ile Lys Lys Ala Gly Asp Gly Ser Lys Lys Ile 
    130                 135                 140                 


Lys Gly Cys Trp Asp Ser Ile His Val Val Glu Val Gln Glu Lys Ser 
145                 150                 155                 160 


Ser Gly Arg Xaa Ala His Tyr Lys Leu Xaa Ser Xaa Val Met Leu Trp 
                165                 170                 175     


Leu Gln Xaa Asn Lys Ser Gly Ser Gly Xaa Met Asn Leu Gly Gly Ser 
            180                 185                 190         


Leu Xaa Arg Gln Met Glu Lys Asp Glu Xaa Val Ser Asp Cys Ser Pro 
        195                 200                 205             


His Ile Ala Asn Ile Gly Arg Leu Val Glu Asp Met Glu Asn Lys Ile 
    210                 215                 220                 


Arg Ser Xaa Leu Asn Glu Ile Tyr Phe Gly Lys Xaa Lys Asp Ile Val 
225                 230                 235                 240 


Asn Gly Leu Arg Ser Val Gln Xaa Phe Ala Asp Lys Ser Lys Gln Glu 
                245                 250                 255     


Ala Leu Lys Asn Asp Leu Val Glu Ala Leu Lys Arg Lys Gln Gln Cys 
            260                 265                 270         


<210> 4959
<211> 480
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<400> 4959
Met Glu Asp Leu Arg Leu Lys His Arg Xaa Leu Gln Lys Asp Cys Asp 
1               5                   10                  15      


Leu Tyr Lys His Arg Met Ala Xaa Val Leu Ala Gln Leu Glu Glu Ile 
            20                  25                  30          


Glu Lys Glu Arg Asp Gln Ala Ile Gln Ser Arg Asp Arg Ile Gln Leu 
        35                  40                  45              


Gln Tyr Ser Gln Ser Leu Ile Glu Lys Asp Gln Tyr Arg Lys Gln Val 
    50                  55                  60                  


Arg Gly Leu Glu Ala Glu Arg Asp Glu Leu Leu Xaa Xaa Leu Xaa Ser 
65                  70                  75                  80  


Leu Glu Gly Xaa Lys Ala Leu Leu Glu Val Gln Leu Gln Arg Ala Gln 
                85                  90                  95      


Gly Gly Xaa Cys Leu Lys Ala Cys Ala Ser Ser His Ser Leu Cys Ser 
            100                 105                 110         


Asn Leu Ser Ser Xaa Trp Ser Leu Ser Glu Phe Pro Ser Pro Leu Gly 
        115                 120                 125             


Gly Pro Glu Ala Xaa Gly Glu Ala Ala Val Met Gly Gly Pro Glu Pro 
    130                 135                 140                 


His Asn Ser Glu Glu Ala Xaa Asp Ser Glu Lys Glu Ile Asn Arg Leu 
145                 150                 155                 160 


Ser Ile Leu Pro Phe Pro Pro Ser Ala Gly Ser Ile Leu Arg Arg Gln 
                165                 170                 175     


Arg Glu Glu Asp Pro Ala Pro Pro Lys Arg Ser Phe Ser Ser Met Ser 
            180                 185                 190         


Asp Ile Xaa Gly Ser Val Xaa Leu Lys Pro Trp Ser Pro Gly Leu Ser 
        195                 200                 205             


Ser Ser Ser Ser Ser Asp Ser Val Trp Pro Leu Gly Lys Pro Glu Gly 
    210                 215                 220                 


Leu Leu Ala Arg Gly Cys Gly Leu Asp Phe Leu Asn Arg Ser Leu Ala 
225                 230                 235                 240 


Ile Arg Val Ser Gly Arg Ser Pro Pro Gly Gly Pro Glu Pro Gln Asp 
                245                 250                 255     


Lys Gly Pro Asp Gly Leu Ser Phe Tyr Gly Asp Arg Trp Ser Gly Ala 
            260                 265                 270         


Val Val Arg Arg Val Leu Ser Gly Pro Gly Ser Ala Arg Met Glu Pro 
        275                 280                 285             


Arg Glu Gln Arg Val Glu Ala Ala Gly Leu Glu Gly Ala Cys Leu Glu 
    290                 295                 300                 


Ala Glu Ala Gln Gln Arg Xaa Leu Leu Trp Asn Gln Gly Ser Xaa Leu 
305                 310                 315                 320 


Pro Ser Leu Met Asp Ser Lys Ala Cys Gln Ser Phe His Glu Ala Leu 
                325                 330                 335     


Glu Ala Trp Ala Lys Gly Pro Gly Ala Glu Pro Phe Tyr Ile Arg Ala 
            340                 345                 350         


Asn Leu Xaa Leu Pro Glu Arg Ala Asp Pro His Ala Leu Cys Val Lys 
        355                 360                 365             


Ala Gln Glu Ile Leu Arg Leu Val Asp Ser Ala Tyr Lys Arg Arg Gln 
    370                 375                 380                 


Glu Trp Phe Cys Xaa Arg Val Asp Pro Leu Xaa Leu Arg Asp Leu Asp 
385                 390                 395                 400 


Arg Gly Xaa Val Pro Asn Tyr Gln Arg Ala Gln Gln Leu Leu Glu Val 
                405                 410                 415     


Gln Glu Lys Cys Leu Pro Ser Ser Arg His Arg Gly Pro Arg Ser Asn 
            420                 425                 430         


Leu Lys Lys Arg Ala Leu Asp Gln Leu Arg Leu Val Arg Pro Lys Pro 
        435                 440                 445             


Val Gly Ala Pro Ala Gly Asp Ser Pro Asp Gln Leu Leu Leu Glu Pro 
    450                 455                 460                 


Cys Ala Glu Pro Glu Arg Ser Leu Arg Pro Tyr Ser Leu Val Arg Pro 
465                 470                 475                 480 


<210> 4960
<211> 746
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<400> 4960
Met Gly Val Gly Val Gly Leu Gly Asn Gly Leu Arg Leu Leu Pro Trp 
1               5                   10                  15      


Met Glu Ala Ser Arg Pro Gly Ala Pro Gly Ser Glu Arg Ile Leu Leu 
            20                  25                  30          


Asp Ile Leu Glu His Asp Trp Arg Glu Ala Gln Asp Ser Arg Gln Glu 
        35                  40                  45              


Leu Cys Gln Lys Leu His Ala Val Gln Gly Glu Leu Gln Trp Ala Glu 
    50                  55                  60                  


Glu Leu Arg Asp Gln Tyr Leu Gln Glu Met Glu Asp Leu Arg Leu Lys 
65                  70                  75                  80  


His Arg Xaa Leu Gln Lys Asp Cys Asp Leu Tyr Lys His Arg Met Ala 
                85                  90                  95      


Xaa Val Leu Ala Gln Leu Glu Glu Ile Glu Lys Glu Arg Asp Gln Ala 
            100                 105                 110         


Ile Gln Ser Arg Asp Arg Ile Gln Leu Gln Tyr Ser Gln Ser Leu Ile 
        115                 120                 125             


Glu Lys Asp Gln Tyr Arg Lys Gln Val Arg Gly Leu Glu Ala Glu Arg 
    130                 135                 140                 


Asp Glu Leu Leu Xaa Xaa Leu Xaa Ser Leu Glu Gly Xaa Lys Ala Leu 
145                 150                 155                 160 


Leu Glu Val Gln Leu Gln Arg Ala Gln Gly Gly Xaa Cys Leu Lys Ala 
                165                 170                 175     


Cys Ala Ser Ser His Ser Leu Cys Ser Asn Leu Ser Ser Xaa Trp Ser 
            180                 185                 190         


Leu Ser Glu Phe Pro Ser Pro Leu Gly Gly Pro Glu Ala Xaa Gly Glu 
        195                 200                 205             


Ala Ala Val Met Gly Gly Pro Glu Pro His Asn Ser Glu Glu Ala Xaa 
    210                 215                 220                 


Asp Ser Glu Lys Glu Ile Asn Arg Leu Ser Ile Leu Pro Phe Pro Pro 
225                 230                 235                 240 


Ser Ala Gly Ser Ile Leu Arg Arg Gln Arg Glu Glu Asp Pro Ala Pro 
                245                 250                 255     


Pro Lys Arg Ser Phe Ser Ser Met Ser Asp Ile Xaa Gly Ser Val Xaa 
            260                 265                 270         


Leu Lys Pro Trp Ser Pro Gly Leu Ser Ser Ser Ser Ser Ser Asp Ser 
        275                 280                 285             


Val Trp Pro Leu Gly Lys Pro Glu Gly Leu Leu Ala Arg Gly Cys Gly 
    290                 295                 300                 


Leu Asp Phe Leu Asn Arg Ser Leu Ala Ile Arg Val Ser Gly Arg Ser 
305                 310                 315                 320 


Pro Pro Gly Gly Pro Glu Pro Gln Asp Lys Gly Pro Asp Gly Leu Ser 
                325                 330                 335     


Phe Tyr Gly Asp Arg Trp Ser Gly Ala Val Val Arg Arg Val Leu Ser 
            340                 345                 350         


Gly Pro Gly Ser Ala Arg Met Glu Pro Arg Glu Gln Arg Val Glu Ala 
        355                 360                 365             


Ala Gly Leu Glu Gly Ala Cys Leu Glu Ala Glu Ala Gln Gln Arg Xaa 
    370                 375                 380                 


Leu Leu Trp Asn Gln Gly Ser Xaa Leu Pro Ser Leu Met Asp Ser Lys 
385                 390                 395                 400 


Ala Cys Gln Ser Phe His Glu Ala Leu Glu Ala Trp Ala Lys Gly Pro 
                405                 410                 415     


Gly Ala Glu Pro Phe Tyr Ile Arg Ala Asn Leu Xaa Leu Pro Glu Arg 
            420                 425                 430         


Ala Asp Pro His Ala Leu Cys Val Lys Ala Gln Glu Ile Leu Arg Leu 
        435                 440                 445             


Val Asp Ser Ala Tyr Lys Arg Arg Gln Glu Trp Phe Cys Xaa Arg Val 
    450                 455                 460                 


Asp Pro Leu Xaa Leu Arg Asp Leu Asp Arg Gly Xaa Val Pro Asn Tyr 
465                 470                 475                 480 


Gln Arg Ala Gln Gln Leu Leu Glu Val Gln Glu Lys Cys Leu Pro Ser 
                485                 490                 495     


Ser Arg His Arg Gly Pro Arg Ser Asn Leu Lys Lys Arg Ala Leu Asp 
            500                 505                 510         


Gln Leu Arg Leu Val Arg Pro Lys Pro Val Gly Ala Pro Ala Gly Asp 
        515                 520                 525             


Ser Pro Asp Gln Leu Leu Leu Glu Pro Cys Ala Glu Pro Glu Arg Ser 
    530                 535                 540                 


Leu Arg Pro Tyr Ser Leu Val Arg Pro Leu Leu Val Ser Ala Leu Arg 
545                 550                 555                 560 


Pro Val Val Leu Leu Pro Glu Cys Leu Ala Pro Arg Leu Ile Arg Asn 
                565                 570                 575     


Leu Leu Asp Leu Pro Ser Ser Arg Leu Asp Phe Gln Val Cys Pro Ala 
            580                 585                 590         


Glu Ser Leu Ser Gly Glu Glu Leu Cys Pro Ser Ser Ala Pro Gly Ala 
        595                 600                 605             


Pro Lys Ala Gln Pro Ala Xaa Pro Gly Leu Gly Ser Arg Ile Arg Ala 
    610                 615                 620                 


Ile Gln Glu Ser Val Gly Lys Lys His Cys Leu Leu Glu Leu Gly Ala 
625                 630                 635                 640 


Arg Gly Val Arg Glu Leu Val Gln Asn Glu Ile Tyr Pro Ile Val Ile 
                645                 650                 655     


His Val Glu Val Xaa Glu Lys Asn Val Arg Glu Val Arg Gly Leu Leu 
            660                 665                 670         


Gly Arg Pro Gly Trp Arg Asp Ser Glu Leu Leu Arg Gln Cys Arg Gly 
        675                 680                 685             


Ser Glu Gln Val Leu Trp Gly Leu Pro Cys Ser Trp Val Gln Val Pro 
    690                 695                 700                 


Ala His Glu Trp Gly His Ala Glu Glu Leu Ala Lys Val Val Arg Gly 
705                 710                 715                 720 


Arg Ile Leu Gln Glu Gln Ala Arg Leu Val Trp Val Glu Cys Gly Ser 
                725                 730                 735     


Ser Arg Gly Cys Pro Ser Ser Ser Glu Ala 
            740                 745     


<210> 4961
<211> 1032
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<400> 4961
Met Pro Gly Arg Ala Glu Ala Gly Glu Ala Glu Glu Glu Ala Gly Ala 
1               5                   10                  15      


Gly Ser Gly Ser Glu Ala Glu Glu Asp Ala Leu Trp Glu Arg Ile Glu 
            20                  25                  30          


Gly Val Arg His Arg Leu Ala Arg Ala Leu Asn Pro Ala Lys Leu Xaa 
        35                  40                  45              


Pro Tyr Leu Arg Gln Cys Arg Val Ile Asp Glu Gln Asp Glu Glu Glu 
    50                  55                  60                  


Val Leu Ser Xaa Tyr Arg Phe Pro Cys Arg Val Asn Arg Xaa Gly Arg 
65                  70                  75                  80  


Leu Met Asp Ile Leu Arg Cys Arg Gly Lys Arg Gly Tyr Glu Ala Phe 
                85                  90                  95      


Leu Glu Ala Leu Glu Phe Tyr Tyr Pro Glu His Phe Xaa Leu Leu Xaa 
            100                 105                 110         


Gly Gln Glu Pro Ala Gln Arg Cys Ser Met Ile Leu Asp Glu Glu Gly 
        115                 120                 125             


Pro Glu Gly Leu Xaa Gln Phe Leu Met Xaa Glu Val Arg Arg Leu Arg 
    130                 135                 140                 


Glu Ala Arg Lys Ser Gln Leu Gln Arg Glu Gln Gln Leu Gln Ala Arg 
145                 150                 155                 160 


Gly Arg Val Leu Glu Glu Glu Arg Ala Gly Leu Glu Gln Arg Leu Arg 
                165                 170                 175     


Asp Gln Gln Gln Ala Gln Glu Arg Cys Gln Arg Leu Arg Glu Asp Trp 
            180                 185                 190         


Glu Ala Gly Ser Leu Glu Leu Leu Arg Leu Lys Asp Glu Asn Tyr Met 
        195                 200                 205             


Ile Ala Met Arg Leu Ala Gln Leu Ser Glu Glu Lys Asn Ser Ala Val 
    210                 215                 220                 


Leu Arg Ser Arg Asp Leu Gln Leu Ala Val Asp Gln Leu Lys Leu Lys 
225                 230                 235                 240 


Val Ser Arg Leu Glu Glu Glu Cys Ala Leu Leu Arg Arg Ala Arg Gly 
                245                 250                 255     


Pro Pro Pro Gly Ala Glu Glu Lys Glu Lys Glu Lys Glu Lys Glu Lys 
            260                 265                 270         


Glu Pro Asp Asn Val Asp Leu Val Ser Glu Leu Arg Ala Glu Asn Gln 
        275                 280                 285             


Arg Leu Xaa Ala Ser Leu Arg Glu Leu Gln Glu Gly Leu Gln Gln Glu 
    290                 295                 300                 


Ala Ser Arg Pro Gly Ala Pro Gly Ser Glu Arg Ile Leu Leu Asp Ile 
305                 310                 315                 320 


Leu Glu His Asp Trp Arg Glu Ala Gln Asp Ser Arg Gln Glu Leu Cys 
                325                 330                 335     


Gln Lys Leu His Ala Val Gln Gly Glu Leu Gln Trp Ala Glu Glu Leu 
            340                 345                 350         


Arg Asp Gln Tyr Leu Gln Glu Met Glu Asp Leu Arg Leu Lys His Arg 
        355                 360                 365             


Xaa Leu Gln Lys Asp Cys Asp Leu Tyr Lys His Arg Met Ala Xaa Val 
    370                 375                 380                 


Leu Ala Gln Leu Glu Glu Ile Glu Lys Glu Arg Asp Gln Ala Ile Gln 
385                 390                 395                 400 


Ser Arg Asp Arg Ile Gln Leu Gln Tyr Ser Gln Ser Leu Ile Glu Lys 
                405                 410                 415     


Asp Gln Tyr Arg Lys Gln Val Arg Gly Leu Glu Ala Glu Arg Asp Glu 
            420                 425                 430         


Leu Leu Xaa Xaa Leu Xaa Ser Leu Glu Gly Xaa Lys Ala Leu Leu Glu 
        435                 440                 445             


Val Gln Leu Gln Arg Ala Gln Gly Gly Xaa Cys Leu Lys Ala Cys Ala 
    450                 455                 460                 


Ser Ser His Ser Leu Cys Ser Asn Leu Ser Ser Xaa Trp Ser Leu Ser 
465                 470                 475                 480 


Glu Phe Pro Ser Pro Leu Gly Gly Pro Glu Ala Xaa Gly Glu Ala Ala 
                485                 490                 495     


Val Met Gly Gly Pro Glu Pro His Asn Ser Glu Glu Ala Xaa Asp Ser 
            500                 505                 510         


Glu Lys Glu Ile Asn Arg Leu Ser Ile Leu Pro Phe Pro Pro Ser Ala 
        515                 520                 525             


Gly Ser Ile Leu Arg Arg Gln Arg Glu Glu Asp Pro Ala Pro Pro Lys 
    530                 535                 540                 


Arg Ser Phe Ser Ser Met Ser Asp Ile Xaa Gly Ser Val Xaa Leu Lys 
545                 550                 555                 560 


Pro Trp Ser Pro Gly Leu Ser Ser Ser Ser Ser Ser Asp Ser Val Trp 
                565                 570                 575     


Pro Leu Gly Lys Pro Glu Gly Leu Leu Ala Arg Gly Cys Gly Leu Asp 
            580                 585                 590         


Phe Leu Asn Arg Ser Leu Ala Ile Arg Val Ser Gly Arg Ser Pro Pro 
        595                 600                 605             


Gly Gly Pro Glu Pro Gln Asp Lys Gly Pro Asp Gly Leu Ser Phe Tyr 
    610                 615                 620                 


Gly Asp Arg Trp Ser Gly Ala Val Val Arg Arg Val Leu Ser Gly Pro 
625                 630                 635                 640 


Gly Ser Ala Arg Met Glu Pro Arg Glu Gln Arg Val Glu Ala Ala Gly 
                645                 650                 655     


Leu Glu Gly Ala Cys Leu Glu Ala Glu Ala Gln Gln Arg Xaa Leu Leu 
            660                 665                 670         


Trp Asn Gln Gly Ser Xaa Leu Pro Ser Leu Met Asp Ser Lys Ala Cys 
        675                 680                 685             


Gln Ser Phe His Glu Ala Leu Glu Ala Trp Ala Lys Gly Pro Gly Ala 
    690                 695                 700                 


Glu Pro Phe Tyr Ile Arg Ala Asn Leu Xaa Leu Pro Glu Arg Ala Asp 
705                 710                 715                 720 


Pro His Ala Leu Cys Val Lys Ala Gln Glu Ile Leu Arg Leu Val Asp 
                725                 730                 735     


Ser Ala Tyr Lys Arg Arg Gln Glu Trp Phe Cys Xaa Arg Val Asp Pro 
            740                 745                 750         


Leu Xaa Leu Arg Asp Leu Asp Arg Gly Xaa Val Pro Asn Tyr Gln Arg 
        755                 760                 765             


Ala Gln Gln Leu Leu Glu Val Gln Glu Lys Cys Leu Pro Ser Ser Arg 
    770                 775                 780                 


His Arg Gly Pro Arg Ser Asn Leu Lys Lys Arg Ala Leu Asp Gln Leu 
785                 790                 795                 800 


Arg Leu Val Arg Pro Lys Pro Val Gly Ala Pro Ala Gly Asp Ser Pro 
                805                 810                 815     


Asp Gln Leu Leu Leu Glu Pro Cys Ala Glu Pro Glu Arg Ser Leu Arg 
            820                 825                 830         


Pro Tyr Ser Leu Val Arg Pro Leu Leu Val Ser Ala Leu Arg Pro Val 
        835                 840                 845             


Val Leu Leu Pro Glu Cys Leu Ala Pro Arg Leu Ile Arg Asn Leu Leu 
    850                 855                 860                 


Asp Leu Pro Ser Ser Arg Leu Asp Phe Gln Val Cys Pro Ala Glu Ser 
865                 870                 875                 880 


Leu Ser Gly Glu Glu Leu Cys Pro Ser Ser Ala Pro Gly Ala Pro Lys 
                885                 890                 895     


Ala Gln Pro Ala Xaa Pro Gly Leu Gly Ser Arg Ile Arg Ala Ile Gln 
            900                 905                 910         


Glu Ser Val Gly Lys Lys His Cys Leu Leu Glu Leu Gly Ala Arg Gly 
        915                 920                 925             


Val Arg Glu Leu Val Gln Asn Glu Ile Tyr Pro Ile Val Ile His Val 
    930                 935                 940                 


Glu Val Xaa Glu Lys Asn Val Arg Glu Val Arg Gly Leu Leu Gly Arg 
945                 950                 955                 960 


Pro Gly Trp Arg Asp Ser Glu Leu Leu Arg Gln Cys Arg Gly Ser Glu 
                965                 970                 975     


Gln Val Leu Trp Gly Leu Pro Cys Ser Trp Val Gln Val Pro Ala His 
            980                 985                 990         


Glu Trp Gly His Ala Glu Glu Leu  Ala Lys Val Val Arg  Gly Arg Ile 
        995                 1000                 1005             


Leu Gln  Glu Gln Ala Arg Leu  Val Trp Val Glu Cys  Gly Ser Ser 
    1010                 1015                 1020             


Arg Gly  Cys Pro Ser Ser Ser  Glu Ala 
    1025                 1030         


<210> 4962
<211> 193
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<400> 4962
Xaa Ser Leu Tyr Cys Pro Gln Met Ala Gly Ala Leu Glu Xaa Gln Val 
1               5                   10                  15      


Leu Ser Phe Ser Ser Met Ser Asp Ile Xaa Gly Ser Val Xaa Leu Lys 
            20                  25                  30          


Pro Trp Ser Pro Gly Leu Ser Ser Ser Ser Ser Ser Asp Ser Val Trp 
        35                  40                  45              


Pro Leu Gly Lys Pro Glu Gly Leu Leu Ala Arg Gly Cys Gly Leu Asp 
    50                  55                  60                  


Phe Leu Asn Arg Ser Leu Ala Ile Arg Val Ser Gly Arg Ser Pro Pro 
65                  70                  75                  80  


Gly Gly Pro Glu Pro Gln Asp Lys Gly Pro Asp Gly Leu Ser Phe Tyr 
                85                  90                  95      


Gly Asp Arg Trp Ser Gly Ala Val Val Arg Arg Val Leu Ser Gly Pro 
            100                 105                 110         


Gly Ser Ala Arg Met Glu Pro Arg Glu Gln Arg Val Glu Ala Ala Gly 
        115                 120                 125             


Leu Glu Gly Ala Cys Leu Glu Ala Glu Ala Gln Gln Arg Xaa Leu Leu 
    130                 135                 140                 


Trp Asn Gln Gly Ser Xaa Leu Pro Ser Leu Met Asp Ser Lys Ala Cys 
145                 150                 155                 160 


Gln Ser Phe His Glu Ala Leu Glu Ala Trp Ala Lys Gly Pro Gly Ala 
                165                 170                 175     


Glu Pro Phe Tyr Ile Arg Ala Asn Leu Xaa Leu Pro Glu Arg Ala Asp 
            180                 185                 190         


Pro 
    


<210> 4963
<211> 272
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<400> 4963
Glu Glu Gly Xaa Asp Ala Ser Pro Ser Ser Cys Gly Ser Leu Pro Ile 
1               5                   10                  15      


Xaa Asn Ser Phe Xaa Lys Met Pro Pro Arg Ser Arg Ser Ser Ile Met 
            20                  25                  30          


Ser Ile Xaa Ala Glu Pro Pro Gly Asn Asp Ser Ile Val Arg Arg Tyr 
        35                  40                  45              


Lys Glu Asp Ala Pro His Arg Ser Xaa Val Glu Glu Asp Asn Asp Ser 
    50                  55                  60                  


Gly Gly Phe Asp Ala Leu Asp Leu Asp Asp Asp Ser His Glu Arg Tyr 
65                  70                  75                  80  


Ser Phe Gly Pro Ser Ser Ile His Ser Ser Ser Ser Ser His Gln Ser 
                85                  90                  95      


Glu Gly Leu Asp Ala Tyr Asp Leu Glu Gln Val Asn Leu Met Phe Arg 
            100                 105                 110         


Lys Phe Ser Leu Glu Arg Pro Phe Arg Pro Ser Val Xaa Ser Val Gly 
        115                 120                 125             


His Val Arg Gly Pro Gly Pro Ser Val Gln His Xaa Xaa Leu Asn Gly 
    130                 135                 140                 


Asp Ser Leu Xaa Ser Gln Leu Xaa Leu Leu Gly Gly Asn Ala Arg Gly 
145                 150                 155                 160 


Ser Phe Val His Ser Val Lys Pro Gly Ser Leu Ala Glu Lys Ala Gly 
                165                 170                 175     


Leu Arg Glu Gly His Gln Leu Leu Leu Leu Glu Gly Cys Ile Arg Gly 
            180                 185                 190         


Glu Arg Gln Ser Val Pro Leu Asp Xaa Cys Xaa Lys Glu Glu Ala His 
        195                 200                 205             


Trp Xaa Ile Gln Arg Cys Ser Gly Pro Val Xaa Leu His Tyr Lys Val 
    210                 215                 220                 


Asn His Glu Gly Tyr Arg Lys Leu Val Lys Asp Met Glu Asp Gly Leu 
225                 230                 235                 240 


Ile Xaa Ser Gly Asp Ser Phe Tyr Ile Arg Leu Asn Leu Asn Ile Ser 
                245                 250                 255     


Ser Gln Leu Asp Ala Cys Xaa Met Ser Leu Lys Cys Asp Asp Val Val 
            260                 265                 270         


<210> 4964
<211> 73
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<400> 4964
Met Pro Gly Gly Gly Pro Glu Met Asp Asp Tyr Met Glu Xaa Leu Lys 
1               5                   10                  15      


Asp Glu Glu Asp Ala Leu Trp Glu Asn Val Glu Cys Asn Arg His Met 
            20                  25                  30          


Leu Ser Arg Tyr Ile Asn Pro Ala Lys Leu Xaa Pro Tyr Leu Arg Gln 
        35                  40                  45              


Cys Lys Val Ile Asp Glu Gln Asp Glu Asp Glu Val Leu Asn Ala Pro 
    50                  55                  60                  


Met Leu Pro Ser Lys Ile Asn Arg Ala 
65                  70              


<210> 4965
<211> 1154
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<400> 4965
Met Pro Gly Gly Gly Pro Glu Met Asp Asp Tyr Met Glu Xaa Leu Lys 
1               5                   10                  15      


Asp Glu Glu Asp Ala Leu Trp Glu Asn Val Glu Cys Asn Arg His Met 
            20                  25                  30          


Leu Ser Arg Tyr Ile Asn Pro Ala Lys Leu Xaa Pro Tyr Leu Arg Gln 
        35                  40                  45              


Cys Lys Val Ile Asp Glu Gln Asp Glu Asp Glu Val Leu Asn Ala Pro 
    50                  55                  60                  


Met Leu Pro Ser Lys Ile Asn Arg Ala Gly Arg Leu Leu Asp Ile Leu 
65                  70                  75                  80  


His Xaa Lys Gly Gln Arg Gly Tyr Val Val Phe Leu Glu Ser Leu Glu 
                85                  90                  95      


Phe Tyr Tyr Pro Glu Leu Tyr Lys Leu Val Xaa Gly Lys Glu Pro Xaa 
            100                 105                 110         


Arg Arg Phe Ser Xaa Ile Val Val Glu Glu Gly His Glu Gly Leu Xaa 
        115                 120                 125             


His Phe Leu Met Asn Glu Val Ile Lys Leu Gln Gln Gln Met Lys Ala 
    130                 135                 140                 


Lys Asp Leu Gln Arg Cys Glu Leu Leu Ala Arg Leu Arg Gln Leu Glu 
145                 150                 155                 160 


Asp Glu Lys Lys Gln Met Xaa Leu Xaa Arg Val Glu Leu Leu Xaa Phe 
                165                 170                 175     


Gln Glu Arg Tyr Tyr Lys Met Lys Glu Glu Arg Asp Ser Tyr Asn Asp 
            180                 185                 190         


Glu Leu Val Lys Val Lys Asp Asp Asn Tyr Asn Leu Ala Met Arg Tyr 
        195                 200                 205             


Ala Gln Leu Ser Glu Glu Lys Asn Met Ala Val Met Arg Ser Arg Asp 
    210                 215                 220                 


Leu Gln Leu Glu Ile Asp Gln Leu Lys His Arg Leu Asn Lys Met Glu 
225                 230                 235                 240 


Glu Glu Cys Lys Leu Glu Arg Asn Gln Ser Leu Lys Leu Lys Asn Asp 
                245                 250                 255     


Ile Glu Asn Arg Pro Lys Lys Glu Gln Val Leu Glu Leu Glu Arg Glu 
            260                 265                 270         


Asn Glu Met Leu Lys Xaa Lys Asn Gln Glu Leu Gln Ser Ile Ile Gln 
        275                 280                 285             


Ala Gly Lys Arg Ser Leu Pro Asp Ser Asp Lys Ala Ile Leu Asp Ile 
    290                 295                 300                 


Leu Glu His Asp Arg Lys Glu Ala Leu Glu Asp Arg Gln Glu Leu Val 
305                 310                 315                 320 


Asn Arg Ile Tyr Asn Leu Gln Glu Glu Ala Arg Gln Ala Glu Glu Leu 
                325                 330                 335     


Arg Asp Lys Tyr Leu Glu Glu Lys Glu Asp Leu Glu Leu Lys Cys Ser 
            340                 345                 350         


Xaa Leu Gly Lys Asp Cys Glu Met Tyr Lys His Arg Met Asn Xaa Val 
        355                 360                 365             


Met Leu Gln Leu Glu Glu Val Glu Arg Glu Arg Asp Gln Ala Phe His 
    370                 375                 380                 


Ser Arg Asp Glu Ala Gln Xaa Gln Tyr Ser Gln Cys Leu Ile Glu Lys 
385                 390                 395                 400 


Asp Lys Tyr Arg Lys Gln Ile Arg Glu Leu Glu Glu Lys Asn Asp Glu 
                405                 410                 415     


Met Arg Ile Glu Met Val Arg Arg Glu Ala Cys Ile Val Asn Leu Glu 
            420                 425                 430         


Ser Lys Leu Arg Arg Leu Ser Lys Asp Ser Asn Asn Leu Asp Gln Ser 
        435                 440                 445             


Leu Pro Arg Asn Leu Pro Val Xaa Ile Ile Ser Gln Asp Phe Gly Asp 
    450                 455                 460                 


Ala Ser Pro Arg Xaa Asn Gly Gln Glu Ala Asp Asp Ser Ser Xaa Ser 
465                 470                 475                 480 


Glu Glu Ser Pro Glu Asp Ser Lys Tyr Phe Leu Pro Tyr His Pro Pro 
                485                 490                 495     


Gln Arg Arg Met Asn Leu Lys Gly Ile Gln Leu Gln Arg Ala Lys Ser 
            500                 505                 510         


Pro Ile Ser Leu Lys Arg Xaa Ser Asp Phe Gln Ala Lys Gly His Glu 
        515                 520                 525             


Glu Glu Gly Xaa Asp Ala Ser Pro Ser Ser Cys Gly Ser Leu Pro Ile 
    530                 535                 540                 


Xaa Asn Ser Phe Xaa Lys Met Gln Pro Pro Arg Ser Arg Ser Ser Ile 
545                 550                 555                 560 


Met Ser Ile Xaa Ala Glu Pro Pro Gly Asn Asp Ser Ile Val Arg Arg 
                565                 570                 575     


Tyr Lys Glu Asp Ala Pro His Arg Ser Xaa Val Glu Glu Asp Asn Asp 
            580                 585                 590         


Ser Gly Gly Phe Asp Ala Leu Asp Leu Asp Asp Asp Ser His Glu Arg 
        595                 600                 605             


Tyr Ser Phe Gly Pro Ser Ser Ile His Ser Ser Ser Ser Ser His Gln 
    610                 615                 620                 


Ser Glu Gly Leu Asp Ala Tyr Asp Leu Glu Gln Val Asn Leu Met Phe 
625                 630                 635                 640 


Arg Lys Phe Ser Leu Glu Arg Pro Phe Arg Pro Ser Val Xaa Ser Val 
                645                 650                 655     


Gly His Val Arg Gly Pro Gly Pro Ser Val Gln His Xaa Xaa Leu Asn 
            660                 665                 670         


Gly Asp Ser Leu Xaa Ser Gln Leu Xaa Leu Leu Gly Gly Asn Ala Arg 
        675                 680                 685             


Gly Ser Phe Val His Ser Val Lys Pro Gly Ser Leu Ala Glu Lys Ala 
    690                 695                 700                 


Gly Leu Arg Glu Gly His Gln Leu Leu Leu Leu Glu Gly Cys Ile Arg 
705                 710                 715                 720 


Gly Glu Arg Gln Ser Val Pro Leu Asp Xaa Cys Xaa Lys Glu Glu Ala 
                725                 730                 735     


His Trp Xaa Ile Gln Arg Cys Ser Gly Pro Val Xaa Leu His Tyr Lys 
            740                 745                 750         


Val Asn His Glu Gly Tyr Arg Lys Leu Val Lys Asp Met Glu Asp Gly 
        755                 760                 765             


Leu Ile Xaa Ser Gly Asp Ser Phe Tyr Ile Arg Leu Asn Leu Asn Ile 
    770                 775                 780                 


Ser Ser Gln Leu Asp Ala Cys Xaa Met Ser Leu Lys Cys Asp Asp Val 
785                 790                 795                 800 


Val His Val Arg Asp Xaa Met Tyr Gln Asp Arg His Glu Trp Leu Cys 
                805                 810                 815     


Ala Arg Val Asp Pro Phe Xaa Asp His Asp Leu Asp Met Gly Xaa Ile 
            820                 825                 830         


Pro Ser Tyr Ser Arg Ala Gln Gln Leu Leu Leu Val Lys Leu Gln Arg 
        835                 840                 845             


Leu Met His Arg Gly Ser Arg Glu Glu Val Asp Gly Xaa His His Xaa 
    850                 855                 860                 


Leu Arg Ala Leu Arg Asn Xaa Leu Gln Pro Glu Glu Ala Leu Ser Xaa 
865                 870                 875                 880 


Ser Asp Pro Arg Val Ser Pro Arg Leu Ser Arg Ala Ser Phe Leu Phe 
                885                 890                 895     


Gly Gln Leu Leu Gln Phe Val Ser Arg Ser Glu Asn Lys Tyr Lys Arg 
            900                 905                 910         


Met Asn Ser Asn Glu Arg Val Arg Ile Ile Ser Gly Ser Pro Leu Gly 
        915                 920                 925             


Ser Leu Ala Arg Ser Ser Leu Asp Ala Xaa Lys Leu Leu Xaa Glu Lys 
    930                 935                 940                 


Gln Glu Glu Leu Asp Pro Glu Ser Glu Leu Gly Lys Asn Leu Ser Leu 
945                 950                 955                 960 


Ile Pro Tyr Ser Leu Val Arg Ala Phe Tyr Cys Glu Arg Arg Arg Pro 
                965                 970                 975     


Val Leu Phe Xaa Pro Xaa Val Leu Ala Lys Xaa Leu Val Gln Arg Leu 
            980                 985                 990         


Leu Asn Ser Gly Gly Ala Met Glu  Phe Xaa Ile Cys Lys  Ser Asp Ile 
        995                 1000                 1005             


Val Xaa  Arg Asp Glu Phe Leu  Arg Arg Gln Lys Xaa  Glu Xaa Ile 
    1010                 1015                 1020             


Ile Tyr  Ser Arg Glu Lys Asn  Pro Asn Ala Phe Glu  Cys Ile Ala 
    1025                 1030                 1035             


Pro Ala  Asn Ile Glu Ala Val  Ala Ala Lys Asn Lys  His Cys Leu 
    1040                 1045                 1050             


Leu Glu  Ala Gly Ile Gly Cys  Xaa Arg Asp Leu Ile  Lys Ser Asn 
    1055                 1060                 1065             


Ile Tyr  Pro Ile Val Leu Phe  Ile Arg Val Cys Glu  Lys Asn Ile 
    1070                 1075                 1080             


Lys Arg  Phe Arg Lys Leu Leu  Pro Arg Pro Glu Xaa  Glu Glu Glu 
    1085                 1090                 1095             


Phe Leu  Arg Val Cys Arg Leu  Lys Glu Lys Glu Leu  Glu Ala Leu 
    1100                 1105                 1110             


Pro Cys  Leu Tyr Ala Xaa Val  Glu Pro Asp Met Trp  Gly Ser Val 
    1115                 1120                 1125             


Glu Glu  Leu Leu Arg Val Val  Lys Asp Lys Ile Gly  Glu Glu Gln 
    1130                 1135                 1140             


Arg Lys  Xaa Ile Trp Val Asp  Glu Asp Gln Leu 
    1145                 1150                 


<210> 4966
<211> 44
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<400> 4966
Met Gly Glu Leu Cys Arg Arg Asp Ser Ala Leu Xaa Ala Leu Asp Glu 
1               5                   10                  15      


Glu Xaa Leu Trp Glu Met Met Glu Ser His Arg His Arg Ile Val Arg 
            20                  25                  30          


Cys Ile Cys Pro Ser Arg Leu Xaa Pro Tyr Leu Arg 
        35                  40                  


<210> 4967
<211> 70
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 4967
Met Gly Glu Leu Cys Arg Arg Asp Ser Ala Leu Xaa Ala Leu Asp Glu 
1               5                   10                  15      


Glu Xaa Leu Trp Glu Met Met Glu Ser His Arg His Arg Ile Val Arg 
            20                  25                  30          


Cys Ile Cys Pro Ser Arg Leu Xaa Pro Tyr Leu Arg Gln Ala Lys Val 
        35                  40                  45              


Leu Cys Gln Leu Asp Glu Glu Glu Val Leu His Ser Pro Arg Leu Xaa 
    50                  55                  60                  


Asn Ser Ala Met Arg Ala 
65                  70  


<210> 4968
<211> 493
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<400> 4968
Met Gly Glu Leu Cys Arg Arg Asp Ser Ala Leu Xaa Ala Leu Asp Glu 
1               5                   10                  15      


Glu Xaa Leu Trp Glu Met Met Glu Ser His Arg His Arg Ile Val Arg 
            20                  25                  30          


Cys Ile Cys Pro Ser Arg Leu Xaa Pro Tyr Leu Arg Gln Ala Lys Val 
        35                  40                  45              


Leu Cys Gln Leu Asp Glu Glu Glu Val Leu His Ser Pro Arg Leu Xaa 
    50                  55                  60                  


Asn Ser Ala Met Arg Ala Gly His Leu Leu Asp Leu Leu Lys Xaa Arg 
65                  70                  75                  80  


Gly Lys Asn Gly Ala Ile Ala Phe Leu Glu Ser Leu Lys Phe His Asn 
                85                  90                  95      


Pro Asp Val Tyr Xaa Leu Val Xaa Gly Leu Gln Pro Asp Val Asp Phe 
            100                 105                 110         


Ser Asn Phe Ser Gly Leu Met Glu Xaa Ser Lys Leu Xaa Glu Cys Leu 
        115                 120                 125             


Ala Gly Ala Ile Gly Ser Leu Gln Glu Glu Leu Asn Gln Glu Lys Gly 
    130                 135                 140                 


Gln Lys Glu Val Leu Leu Arg Arg Cys Gln Gln Leu Gln Glu His Leu 
145                 150                 155                 160 


Gly Leu Ala Glu Xaa Arg Ala Glu Gly Leu His Gln Leu Glu Ala Asp 
                165                 170                 175     


His Ser Arg Met Lys Arg Glu Val Ser Ala His Phe His Glu Val Leu 
            180                 185                 190         


Arg Leu Lys Asp Glu Met Leu Ser Leu Ser Leu His Tyr Ser Asn Ala 
        195                 200                 205             


Leu Gln Glu Lys Glu Leu Ala Ala Ser Arg Cys Arg Ser Leu Gln Glu 
    210                 215                 220                 


Glu Leu Tyr Leu Leu Lys Gln Glu Leu Gln Arg Ala Asn Met Val Ser 
225                 230                 235                 240 


Ser Cys Glu Leu Glu Leu Gln Glu Gln Ser Leu Arg Xaa Ala Ser Asp 
                245                 250                 255     


Gln Glu Ser Gly Asp Glu Glu Leu Asn Arg Leu Lys Glu Glu Asn Glu 
            260                 265                 270         


Lys Leu Arg Ser Leu Xaa Phe Ser Leu Ala Glu Lys Asp Ile Leu Glu 
        275                 280                 285             


Gln Ser Leu Asp Glu Ala Arg Gly Ser Arg Gln Glu Leu Val Glu Arg 
    290                 295                 300                 


Ile His Ser Leu Arg Glu Arg Ala Val Ala Ala Glu Arg Gln Arg Glu 
305                 310                 315                 320 


Gln Gly Glu Gly Glu Cys Ala Ala Gly Pro Gly Val Arg Ala Ala Glu 
                325                 330                 335     


Gly Ala Arg Pro Gly Val Leu Arg Glu Gly Gln Cys Ser Glu Gly Asp 
            340                 345                 350         


Phe Pro Glu Pro Gly Gly Glu Gly Leu Pro Pro Gln Ala Gly Val Arg 
        355                 360                 365             


Ala Asp Gly Pro Gly Leu Arg Ala Ala His Xaa Ala Ser Pro Ala Ala 
    370                 375                 380                 


Gly Arg Ala Ser Gly Cys Ala Gln Ala Gly Ser Gln Asp Gln Gly Ala 
385                 390                 395                 400 


Leu Ser Xaa Gly Glu Ala Ala Ala Gly Ala Asp Ala Cys His Leu Pro 
                405                 410                 415     


Gln Arg Arg Gln Arg Leu Gln Pro Arg Gln Leu His Arg Val Ser Ala 
            420                 425                 430         


Leu Val Gly Pro Glu Cys His Val Gln Pro Arg Ala Gly Gly Gln Leu 
        435                 440                 445             


Pro Leu Gln Gln Pro Arg Ala Pro Gln Pro Ala Val Pro Val Gln Ala 
    450                 455                 460                 


Gly Gly Arg Gly Leu Arg Gly Arg Xaa Leu Val Phe Gln Gln Leu Pro 
465                 470                 475                 480 


Gly Asp Pro Gly Gly Arg Pro Gly Ser Pro Ala Gly Ser 
                485                 490             


<210> 4969
<211> 740
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<400> 4969
Met Gly Glu Leu Cys Arg Arg Asp Ser Ala Leu Xaa Ala Leu Asp Glu 
1               5                   10                  15      


Glu Xaa Leu Trp Glu Met Met Glu Ser His Arg His Arg Ile Val Arg 
            20                  25                  30          


Cys Ile Cys Pro Ser Arg Leu Xaa Pro Tyr Leu Arg Gln Ala Lys Val 
        35                  40                  45              


Leu Cys Gln Leu Asp Glu Glu Glu Val Leu His Ser Pro Arg Leu Xaa 
    50                  55                  60                  


Asn Ser Ala Met Arg Ala Gly His Leu Leu Asp Leu Leu Lys Xaa Arg 
65                  70                  75                  80  


Gly Lys Asn Gly Ala Ile Ala Phe Leu Glu Ser Leu Lys Phe His Asn 
                85                  90                  95      


Pro Asp Val Tyr Xaa Leu Val Xaa Gly Leu Gln Pro Asp Val Asp Phe 
            100                 105                 110         


Ser Asn Phe Ser Gly Leu Met Glu Xaa Ser Lys Leu Xaa Glu Cys Leu 
        115                 120                 125             


Ala Gly Ala Ile Gly Ser Leu Gln Glu Glu Leu Asn Gln Glu Lys Gly 
    130                 135                 140                 


Gln Lys Glu Val Leu Leu Arg Arg Cys Gln Gln Leu Gln Glu His Leu 
145                 150                 155                 160 


Gly Leu Ala Glu Xaa Arg Ala Glu Gly Leu His Gln Leu Glu Ala Asp 
                165                 170                 175     


His Ser Arg Met Lys Arg Glu Val Ser Ala His Phe His Glu Val Leu 
            180                 185                 190         


Arg Leu Lys Asp Glu Met Leu Ser Leu Ser Leu His Tyr Ser Asn Ala 
        195                 200                 205             


Leu Gln Glu Lys Glu Leu Ala Ala Ser Arg Cys Arg Ser Leu Gln Glu 
    210                 215                 220                 


Glu Leu Tyr Leu Leu Lys Gln Glu Leu Gln Arg Ala Asn Met Val Ser 
225                 230                 235                 240 


Ser Cys Glu Leu Glu Leu Gln Glu Gln Ser Leu Arg Xaa Ala Ser Asp 
                245                 250                 255     


Gln Glu Ser Gly Asp Glu Glu Leu Asn Arg Leu Lys Glu Glu Asn Glu 
            260                 265                 270         


Lys Leu Arg Ser Leu Xaa Phe Ser Leu Ala Glu Lys Asp Ile Leu Glu 
        275                 280                 285             


Gln Ser Leu Asp Glu Ala Arg Gly Ser Arg Gln Glu Leu Val Glu Arg 
    290                 295                 300                 


Ile His Ser Leu Arg Glu Arg Ala Val Ala Ala Glu Arg Gln Arg Glu 
305                 310                 315                 320 


Gln Tyr Trp Glu Glu Lys Glu Gln Xaa Leu Leu Gln Phe Gln Lys Ser 
                325                 330                 335     


Lys Met Ala Cys Gln Leu Tyr Arg Glu Lys Val Asn Ala Leu Gln Ala 
            340                 345                 350         


Gln Val Cys Glu Leu Gln Lys Glu Arg Asp Gln Ala Tyr Ser Ala Arg 
        355                 360                 365             


Asp Ser Ala Gln Arg Glu Ile Ser Gln Ser Leu Val Glu Lys Asp Ser 
    370                 375                 380                 


Leu Arg Arg Gln Val Phe Glu Leu Xaa Asp Gln Val Cys Glu Leu Arg 
385                 390                 395                 400 


Xaa Gln Leu Arg Gln Leu Gln Ala Glu Pro Pro Gly Val Leu Lys Gln 
                405                 410                 415     


Glu Ala Arg Xaa Arg Glu Pro Cys Pro Arg Glu Lys Gln Arg Leu Val 
            420                 425                 430         


Arg Met His Ala Ile Cys Pro Arg Asp Asp Ser Asp Cys Ser Leu Val 
        435                 440                 445             


Ser Ser Xaa Glu Ser Gln Leu Leu Ser Asp Leu Ser Ala Xaa Ser Ser 
    450                 455                 460                 


Arg Glu Leu Val Asp Ser Phe Arg Ser Ser Ser Pro Ala Pro Pro Ser 
465                 470                 475                 480 


Gln Gln Ser Leu Tyr Lys Arg Val Ala Glu Asp Phe Gly Glu Glu Pro 
                485                 490                 495     


Trp Ser Phe Ser Ser Cys Leu Glu Ile Pro Glu Gly Asp Pro Gly Ala 
            500                 505                 510         


Leu Pro Gly Ala Lys Ala Gly Asp Pro His Leu Asp Tyr Glu Leu Leu 
        515                 520                 525             


Asp Xaa Ala Asp Leu Pro Gln Leu Glu Ser Ser Leu Gln Pro Val Ser 
    530                 535                 540                 


Pro Gly Arg Leu Asp Val Ser Glu Ser Gly Val Leu Met Arg Arg Arg 
545                 550                 555                 560 


Pro Ala Arg Arg Ile Leu Ser Gln Val Xaa Met Leu Ala Phe Gln Gly 
                565                 570                 575     


Asp Ala Leu Leu Glu Gln Ile Ser Val Ile Gly Gly Asn Leu Xaa Gly 
            580                 585                 590         


Ile Phe Ile His Arg Val Xaa Pro Gly Ser Ala Ala Asp Gln Met Ala 
        595                 600                 605             


Leu Arg Pro Gly Xaa Gln Ile Val Met Val Asp Tyr Glu Ala Ser Glu 
    610                 615                 620                 


Pro Leu Phe Lys Ala Val Leu Glu Asp Xaa Xaa Leu Glu Glu Ala Val 
625                 630                 635                 640 


Gly Leu Leu Arg Arg Val Asp Gly Phe Cys Cys Leu Ser Val Lys Val 
                645                 650                 655     


Asn Xaa Asp Gly Tyr Lys Arg Leu Leu Gln Asp Leu Glu Ala Lys Val 
            660                 665                 670         


Ala Xaa Ser Gly Asp Ser Phe Tyr Ile Arg Val Asn Leu Ala Met Glu 
        675                 680                 685             


Gly Arg Ala Lys Gly Glu Leu Gln Val His Cys Asn Glu Val Leu His 
    690                 695                 700                 


Val Xaa Asp Xaa Met Phe Gln Gly Cys Gly Cys Trp His Ala His Arg 
705                 710                 715                 720 


Val Asn Ser Tyr Xaa Met Lys Asp Xaa Ala Ala His Gly Xaa Ile Pro 
                725                 730                 735     


Asn Tyr Ser Arg 
            740 


<210> 4970
<211> 1004
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<400> 4970
Met Gly Glu Leu Cys Arg Arg Asp Ser Ala Leu Xaa Ala Leu Asp Glu 
1               5                   10                  15      


Glu Xaa Leu Trp Glu Met Met Glu Ser His Arg His Arg Ile Val Arg 
            20                  25                  30          


Cys Ile Cys Pro Ser Arg Leu Xaa Pro Tyr Leu Arg Gln Ala Lys Val 
        35                  40                  45              


Leu Cys Gln Leu Asp Glu Glu Glu Val Leu His Ser Pro Arg Leu Xaa 
    50                  55                  60                  


Asn Ser Ala Met Arg Ala Gly His Leu Leu Asp Leu Leu Lys Xaa Arg 
65                  70                  75                  80  


Gly Lys Asn Gly Ala Ile Ala Phe Leu Glu Ser Leu Lys Phe His Asn 
                85                  90                  95      


Pro Asp Val Tyr Xaa Leu Val Xaa Gly Leu Gln Pro Asp Val Asp Phe 
            100                 105                 110         


Ser Asn Phe Ser Gly Leu Met Glu Xaa Ser Lys Leu Xaa Glu Cys Leu 
        115                 120                 125             


Ala Gly Ala Ile Gly Ser Leu Gln Glu Glu Leu Asn Gln Glu Lys Gly 
    130                 135                 140                 


Gln Lys Glu Val Leu Leu Arg Arg Cys Gln Gln Leu Gln Glu His Leu 
145                 150                 155                 160 


Gly Leu Ala Glu Xaa Arg Ala Glu Gly Leu His Gln Leu Glu Ala Asp 
                165                 170                 175     


His Ser Arg Met Lys Arg Glu Val Ser Ala His Phe His Glu Val Leu 
            180                 185                 190         


Arg Leu Lys Asp Glu Met Leu Ser Leu Ser Leu His Tyr Ser Asn Ala 
        195                 200                 205             


Leu Gln Glu Lys Glu Leu Ala Ala Ser Arg Cys Arg Ser Leu Gln Glu 
    210                 215                 220                 


Glu Leu Tyr Leu Leu Lys Gln Glu Leu Gln Arg Ala Asn Met Val Ser 
225                 230                 235                 240 


Ser Cys Glu Leu Glu Leu Gln Glu Gln Ser Leu Arg Xaa Ala Ser Asp 
                245                 250                 255     


Gln Glu Ser Gly Asp Glu Glu Leu Asn Arg Leu Lys Glu Glu Asn Glu 
            260                 265                 270         


Lys Leu Arg Ser Leu Xaa Phe Ser Leu Ala Glu Lys Asp Ile Leu Glu 
        275                 280                 285             


Gln Ser Leu Asp Glu Ala Arg Gly Ser Arg Gln Glu Leu Val Glu Arg 
    290                 295                 300                 


Ile His Ser Leu Arg Glu Arg Ala Val Ala Ala Glu Arg Gln Arg Glu 
305                 310                 315                 320 


Gln Tyr Trp Glu Glu Lys Glu Gln Xaa Leu Leu Gln Phe Gln Lys Ser 
                325                 330                 335     


Lys Met Ala Cys Gln Leu Tyr Arg Glu Lys Val Asn Ala Leu Gln Ala 
            340                 345                 350         


Gln Val Cys Glu Leu Gln Lys Glu Arg Asp Gln Ala Tyr Ser Ala Arg 
        355                 360                 365             


Asp Ser Ala Gln Arg Glu Ile Ser Gln Ser Leu Val Glu Lys Asp Ser 
    370                 375                 380                 


Leu Arg Arg Gln Val Phe Glu Leu Xaa Asp Gln Val Cys Glu Leu Arg 
385                 390                 395                 400 


Xaa Gln Leu Arg Gln Leu Gln Ala Glu Pro Pro Gly Val Leu Lys Gln 
                405                 410                 415     


Glu Ala Arg Xaa Arg Glu Pro Cys Pro Arg Glu Lys Gln Arg Leu Val 
            420                 425                 430         


Arg Met His Ala Ile Cys Pro Arg Asp Asp Ser Asp Cys Ser Leu Val 
        435                 440                 445             


Ser Ser Xaa Glu Ser Gln Leu Leu Ser Asp Leu Ser Ala Xaa Ser Ser 
    450                 455                 460                 


Arg Glu Leu Val Asp Ser Phe Arg Ser Ser Ser Pro Ala Pro Pro Ser 
465                 470                 475                 480 


Gln Gln Ser Leu Tyr Lys Arg Val Ala Glu Asp Phe Gly Glu Glu Pro 
                485                 490                 495     


Trp Ser Phe Ser Ser Cys Leu Glu Ile Pro Glu Gly Asp Pro Gly Ala 
            500                 505                 510         


Leu Pro Gly Ala Lys Ala Gly Asp Pro His Leu Asp Tyr Glu Leu Leu 
        515                 520                 525             


Asp Xaa Ala Asp Leu Pro Gln Leu Glu Ser Ser Leu Gln Pro Val Ser 
    530                 535                 540                 


Pro Gly Arg Leu Asp Val Ser Glu Ser Gly Val Leu Met Arg Arg Arg 
545                 550                 555                 560 


Pro Ala Arg Arg Ile Leu Ser Gln Val Xaa Met Leu Ala Phe Gln Gly 
                565                 570                 575     


Asp Ala Leu Leu Glu Gln Ile Ser Val Ile Gly Gly Asn Leu Xaa Gly 
            580                 585                 590         


Ile Phe Ile His Arg Val Xaa Pro Gly Ser Ala Ala Asp Gln Met Ala 
        595                 600                 605             


Leu Arg Pro Gly Xaa Gln Ile Val Met Val Asp Tyr Glu Ala Ser Glu 
    610                 615                 620                 


Pro Leu Phe Lys Ala Val Leu Glu Asp Xaa Xaa Leu Glu Glu Ala Val 
625                 630                 635                 640 


Gly Leu Leu Arg Arg Val Asp Gly Phe Cys Cys Leu Ser Val Lys Val 
                645                 650                 655     


Asn Xaa Asp Gly Tyr Lys Arg Leu Leu Gln Asp Leu Glu Ala Lys Val 
            660                 665                 670         


Ala Xaa Ser Gly Asp Ser Phe Tyr Ile Arg Val Asn Leu Ala Met Glu 
        675                 680                 685             


Gly Arg Ala Lys Gly Glu Leu Gln Val His Cys Asn Glu Val Leu His 
    690                 695                 700                 


Val Xaa Asp Xaa Met Phe Gln Gly Cys Gly Cys Trp His Ala His Arg 
705                 710                 715                 720 


Val Asn Ser Tyr Xaa Met Lys Asp Xaa Ala Ala His Gly Xaa Ile Pro 
                725                 730                 735     


Asn Tyr Ser Arg Ala Gln Gln Gln Leu Ile Ala Leu Ile Gln Asp Met 
            740                 745                 750         


Xaa Gln Gln Cys Xaa Val Xaa Arg Lys Pro Ser Ser Gly Gly Pro Gln 
        755                 760                 765             


Lys Leu Val Arg Ile Val Ser Met Asp Lys Ala Lys Ala Ser Pro Leu 
    770                 775                 780                 


Arg Leu Ser Phe Asp Arg Gly Gln Leu Asp Pro Ser Arg Met Glu Gly 
785                 790                 795                 800 


Ser Ser Xaa Cys Phe Trp Ala Glu Ser Cys Leu Xaa Leu Val Pro Tyr 
                805                 810                 815     


Xaa Leu Val Arg Pro His Arg Pro Ala Arg Pro Arg Pro Val Leu Leu 
            820                 825                 830         


Val Pro Arg Ala Val Gly Lys Ile Leu Ser Glu Lys Leu Cys Leu Leu 
        835                 840                 845             


Gln Gly Phe Lys Lys Cys Leu Ala Glu Tyr Leu Ser Gln Glu Glu Tyr 
    850                 855                 860                 


Glu Ala Trp Ser Gln Arg Gly Asp Ile Ile Gln Glu Gly Glu Val Ser 
865                 870                 875                 880 


Gly Gly Arg Cys Trp Val Xaa Arg His Ala Val Glu Ser Leu Met Glu 
                885                 890                 895     


Lys Asn Xaa His Ala Leu Leu Asp Val Gln Leu Asp Ser Val Cys Xaa 
            900                 905                 910         


Leu His Arg Met Asp Ile Phe Pro Ile Val Ile His Val Ser Val Asn 
        915                 920                 925             


Glu Lys Met Ala Lys Lys Leu Lys Lys Gly Leu Gln Arg Leu Gly Xaa 
    930                 935                 940                 


Ser Glu Glu Gln Leu Leu Glu Ala Ala Arg Gln Glu Glu Gly Asp Leu 
945                 950                 955                 960 


Asp Arg Ala Pro Cys Leu Tyr Ser Ser Leu Ala Pro Asp Gly Trp Ser 
                965                 970                 975     


Asp Leu Asp Gly Leu Leu Ser Cys Val Arg Gln Ala Ile Ala Asp Glu 
            980                 985                 990         


Gln Lys Lys Val Val Trp Xaa Glu  Gln Ser Pro Arg 
        995                 1000                 


<210> 4971
<211> 475
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<400> 4971
Xaa Tyr Ser Asn Ala Leu Gln Glu Lys Glu Leu Ala Ala Ser Arg Cys 
1               5                   10                  15      


Arg Ser Leu Gln Glu Glu Leu Tyr Leu Leu Lys Gln Glu Leu Gln Arg 
            20                  25                  30          


Ala Asn Met Val Ser Ser Cys Glu Leu Glu Leu Gln Glu Gln Ser Leu 
        35                  40                  45              


Arg Xaa Ala Ser Asp Gln Glu Ser Gly Asp Glu Glu Leu Asn Arg Leu 
    50                  55                  60                  


Lys Glu Glu Asn Glu Lys Leu Arg Ser Leu Xaa Phe Ser Leu Ala Glu 
65                  70                  75                  80  


Lys Asp Ile Leu Glu Gln Ser Leu Asp Glu Ala Arg Gly Ser Arg Gln 
                85                  90                  95      


Glu Leu Val Glu Arg Ile His Ser Leu Arg Glu Arg Ala Val Ala Ala 
            100                 105                 110         


Glu Arg Gln Arg Glu Gln Tyr Trp Glu Glu Lys Glu Gln Xaa Leu Leu 
        115                 120                 125             


Gln Phe Gln Lys Ser Lys Met Ala Cys Gln Leu Tyr Arg Glu Lys Val 
    130                 135                 140                 


Asn Ala Leu Gln Ala Gln Val Cys Glu Leu Gln Lys Glu Arg Asp Gln 
145                 150                 155                 160 


Ala Tyr Ser Ala Arg Asp Ser Ala Gln Arg Glu Ile Ser Gln Ser Leu 
                165                 170                 175     


Val Glu Lys Asp Ser Leu Arg Arg Gln Val Phe Glu Leu Xaa Asp Gln 
            180                 185                 190         


Val Cys Glu Leu Arg Xaa Gln Leu Arg Gln Leu Gln Ala Glu Pro Pro 
        195                 200                 205             


Gly Val Leu Lys Gln Glu Ala Arg Xaa Arg Glu Pro Cys Pro Arg Glu 
    210                 215                 220                 


Lys Gln Arg Leu Val Arg Met His Ala Ile Cys Pro Arg Asp Asp Ser 
225                 230                 235                 240 


Asp Cys Ser Leu Val Ser Ser Xaa Glu Ser Gln Leu Leu Ser Asp Leu 
                245                 250                 255     


Ser Ala Xaa Ser Ser Arg Glu Leu Val Asp Ser Phe Arg Ser Ser Ser 
            260                 265                 270         


Pro Ala Pro Pro Ser Gln Gln Ser Leu Tyr Lys Arg Val Ala Glu Asp 
        275                 280                 285             


Phe Gly Glu Glu Pro Trp Ser Phe Ser Ser Cys Leu Glu Ile Pro Glu 
    290                 295                 300                 


Gly Asp Pro Gly Ala Leu Pro Gly Ala Lys Ala Gly Asp Pro His Leu 
305                 310                 315                 320 


Asp Tyr Glu Leu Leu Asp Xaa Ala Asp Leu Pro Gln Leu Glu Ser Ser 
                325                 330                 335     


Leu Gln Pro Val Ser Pro Gly Arg Leu Asp Val Ser Glu Ser Gly Val 
            340                 345                 350         


Leu Met Arg Arg Arg Pro Ala Arg Arg Ile Leu Ser Gln Val Xaa Met 
        355                 360                 365             


Leu Ala Phe Gln Gly Asp Ala Leu Leu Glu Gln Ile Ser Val Ile Gly 
    370                 375                 380                 


Gly Asn Leu Xaa Gly Ile Phe Ile His Arg Val Xaa Pro Gly Ser Ala 
385                 390                 395                 400 


Ala Asp Gln Met Ala Leu Arg Pro Gly Xaa Gln Ile Val Met Val Ile 
                405                 410                 415     


Arg Gly Tyr Ser Arg Xaa Trp Arg Pro Lys Trp Arg Pro Arg Gly Xaa 
            420                 425                 430         


His Ser Xaa Ser Gly Ser Xaa Trp Pro Trp Arg Ala Gly Pro Lys Gly 
        435                 440                 445             


Ser Cys Arg Cys Ile Ala Xaa Arg Ser Cys Xaa Ser Pro Xaa Pro Cys 
    450                 455                 460                 


Ser Arg Ala Ala Ala Ala Gly Met Pro Xaa Ala 
465                 470                 475 


<210> 4972
<211> 183
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<400> 4972
Met Xaa Asp Gln Xaa Tyr Cys Asp Arg Leu Val Gln Asp Xaa Pro Phe 
1               5                   10                  15      


Leu Xaa Gly His Gly Arg Leu Ser Glu Gln Gln Val Asp Arg Ile Ile 
            20                  25                  30          


Leu Gln Leu Asn Arg Tyr Tyr Pro Gln Ile Leu Xaa Asn Lys Glu Ala 
        35                  40                  45              


Glu Lys Phe Arg Asn Pro Lys Ala Ser Leu Arg Val Arg Leu Cys Asp 
    50                  55                  60                  


Leu Leu Ser His Leu Gln Arg Ser Gly Glu Arg Asp Cys Gln Glu Phe 
65                  70                  75                  80  


Tyr Arg Ala Leu Tyr Ile His Ala Gln Pro Leu His Ser Arg Leu Pro 
                85                  90                  95      


Ser Arg His Ala Leu Gln Asn Ser Asp Cys Xaa Glu Leu Asp Ser Gly 
            100                 105                 110         


Ser Gln Ser Gly Glu Leu Ser Asn Arg Gly Pro Met Ser Phe Leu Ala 
        115                 120                 125             


Gly Leu Gly Leu Ala Val Gly Leu Ala Leu Leu Leu Tyr Cys Tyr Pro 
    130                 135                 140                 


Pro Asp Pro Lys Gly Leu Pro Gly Xaa Arg Arg Val Leu Gly Phe Ser 
145                 150                 155                 160 


Pro Val Ile Ile Asp Arg His Val Ser Arg Tyr Leu Leu Ala Phe Leu 
                165                 170                 175     


Ala Asp Asp Leu Gly Gly Leu 
            180             


<210> 4973
<211> 228
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<400> 4973
Met Xaa Asp Gln Xaa Tyr Cys Asp Arg Leu Val Gln Asp Xaa Pro Phe 
1               5                   10                  15      


Leu Xaa Gly His Gly Arg Leu Ser Glu Gln Gln Val Asp Arg Ile Ile 
            20                  25                  30          


Leu Gln Leu Asn Arg Tyr Tyr Pro Gln Ile Leu Xaa Asn Lys Glu Ala 
        35                  40                  45              


Glu Lys Phe Arg Asn Pro Lys Ala Ser Leu Arg Val Arg Leu Cys Asp 
    50                  55                  60                  


Leu Leu Ser His Leu Gln Arg Ser Gly Glu Arg Asp Cys Gln Glu Phe 
65                  70                  75                  80  


Tyr Arg Ala Leu Tyr Ile His Ala Gln Pro Leu His Ser Arg Leu Pro 
                85                  90                  95      


Ser Arg His Ala Leu Arg Lys Phe His Ile Xaa Asn His Ala Cys Leu 
            100                 105                 110         


Val Leu Ala Arg Gly Gly His Pro Ser Leu Pro Leu Met Ala Trp Met 
        115                 120                 125             


Ser Ser Met Xaa Xaa Gln Val Cys Cys Ser Pro Gly Leu Ala Ser Pro 
    130                 135                 140                 


Leu Ala Ser Ala Pro Pro Gln Arg Pro Pro Ser Gly Pro Glu Gly Arg 
145                 150                 155                 160 


Val Trp Gln Ala Gln Ala Val Gln Met Leu Val Ser Val Ser His Phe 
                165                 170                 175     


Leu Pro Leu Pro Pro Ser Leu Ser His Gly Ser Phe His Xaa Ala Trp 
            180                 185                 190         


Gly Ile Leu Tyr Val His Ser Cys Pro Ser Phe Ser Asn Leu Ile Pro 
        195                 200                 205             


Arg Gly Ser Leu His Val Cys Val Asp Ser Asn Leu Val Pro Xaa Ala 
    210                 215                 220                 


Ala Trp Arg Ser 
225             


<210> 4974
<211> 39
<212> PRT
<213> Homo sapiens

<400> 4974
Met Glu Lys Lys Glu Cys Pro Glu Lys Ser Ser Ser Ser Glu Glu Glu 
1               5                   10                  15      


Leu Pro Arg Arg Asp Ser Gly Ser Ser Arg Asn Ile Asp Ala Ser Lys 
            20                  25                  30          


Leu Ile Arg Leu Gln Gly Ser 
        35                  


<210> 4975
<211> 70
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<400> 4975
Met Glu Lys Lys Glu Cys Pro Glu Lys Ser Ser Ser Ser Glu Glu Glu 
1               5                   10                  15      


Leu Pro Arg Arg Asp Ser Gly Ser Ser Arg Asn Ile Asp Ala Ser Lys 
            20                  25                  30          


Leu Ile Arg Leu Gln Gly Ser Arg Lys Leu Leu Val Asp Asn Ser Ile 
        35                  40                  45              


Arg Glu Leu Gln Tyr Xaa Lys Xaa Gly Ile Phe Phe Gln Ala Glu Ala 
    50                  55                  60                  


Cys Val Xaa Asn Asp Xaa 
65                  70  


<210> 4976
<211> 132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 4976
Met Glu Lys Lys Glu Cys Pro Glu Lys Ser Ser Ser Ser Glu Glu Glu 
1               5                   10                  15      


Leu Pro Arg Arg Asp Ser Gly Ser Ser Arg Asn Ile Asp Ala Ser Lys 
            20                  25                  30          


Leu Ile Arg Leu Gln Gly Ser Arg Lys Leu Leu Val Asp Asn Ser Ile 
        35                  40                  45              


Arg Glu Leu Gln Tyr Xaa Lys Xaa Gly Ile Phe Phe Gln Ala Glu Ala 
    50                  55                  60                  


Cys Val Xaa Asn Asp Xaa Val Tyr Arg Glu Leu Pro Cys Val Ser Glu 
65                  70                  75                  80  


Xaa Leu Cys Asp Ile Ser His Phe Phe Gln Glu Asp Asp Glu Xaa Glu 
                85                  90                  95      


Ala Glu Pro Leu Leu Phe Arg Ala Val Pro Glu Cys Gln Leu Ser Gly 
            100                 105                 110         


Gly Asp Ile Pro Arg Arg His Leu Leu Arg Arg Glu Ser Asn Ser Phe 
        115                 120                 125             


Leu Leu Cys Phe 
    130         


<210> 4977
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 4977
Met Glu Lys Lys Glu Cys Pro Glu Lys Ser Ser Ser Ser Glu Glu Glu 
1               5                   10                  15      


Leu Pro Arg Arg Asp Ser Gly Ser Ser Arg Asn Ile Asp Ala Ser Lys 
            20                  25                  30          


Leu Ile Arg Leu Gln Gly Ser Arg Lys Leu Leu Val Asp Asn Ser Ile 
        35                  40                  45              


Arg Glu Leu Gln Tyr Xaa Lys Xaa Gly Ile Phe Phe Gln Ala Glu Ala 
    50                  55                  60                  


Cys Val Xaa Asn Asp Xaa Val Tyr Arg Glu Leu Pro Cys Val Ser Glu 
65                  70                  75                  80  


Xaa Leu Cys Asp Ile Ser His Phe Phe Gln Glu Asp Asp Glu Xaa Glu 
                85                  90                  95      


Ala Glu Pro Leu Leu Phe Arg Ala Val Pro Glu Cys Gln Leu Ser Gly 
            100                 105                 110         


Gly Asp Ile Pro Arg Tyr Leu Phe Phe Leu Asn Leu Ile His Val Ser 
        115                 120                 125             


Val Ser Leu Leu Val Ser Phe Xaa Ser Lys 
    130                 135             


<210> 4978
<211> 146
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 4978
Met Glu Lys Lys Glu Cys Pro Glu Lys Ser Ser Ser Ser Glu Glu Glu 
1               5                   10                  15      


Leu Pro Arg Arg Asp Ser Gly Ser Ser Arg Asn Ile Asp Ala Ser Lys 
            20                  25                  30          


Leu Ile Arg Leu Gln Gly Ser Arg Lys Leu Leu Val Asp Asn Ser Ile 
        35                  40                  45              


Arg Glu Leu Gln Tyr Xaa Lys Xaa Gly Ile Phe Phe Gln Ala Glu Ala 
    50                  55                  60                  


Cys Val Xaa Asn Asp Xaa Val Tyr Arg Glu Leu Pro Cys Val Ser Glu 
65                  70                  75                  80  


Xaa Leu Cys Asp Ile Ser His Phe Phe Gln Glu Asp Asp Glu Xaa Glu 
                85                  90                  95      


Ala Glu Pro Leu Leu Phe Arg Ala Val Pro Glu Cys Gln Leu Ser Gly 
            100                 105                 110         


Gly Asp Ile Pro Ser Leu Asp Pro Pro Ser Leu Arg Glu Leu Ser Val 
        115                 120                 125             


Met Xaa Gly Val Phe His Ser Leu Leu His Ser Val Ile Ala Val Ser 
    130                 135                 140                 


Asp Met 
145     


<210> 4979
<211> 392
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<400> 4979
Met Glu Lys Lys Glu Cys Pro Glu Lys Ser Ser Ser Ser Glu Glu Glu 
1               5                   10                  15      


Leu Pro Arg Arg Asp Ser Gly Ser Ser Arg Asn Ile Asp Ala Ser Lys 
            20                  25                  30          


Leu Ile Arg Leu Gln Gly Ser Arg Lys Leu Leu Val Asp Asn Ser Ile 
        35                  40                  45              


Arg Glu Leu Gln Tyr Xaa Lys Xaa Gly Ile Phe Phe Gln Ala Glu Ala 
    50                  55                  60                  


Cys Val Xaa Asn Asp Xaa Val Tyr Arg Glu Leu Pro Cys Val Ser Glu 
65                  70                  75                  80  


Xaa Leu Cys Asp Ile Ser His Phe Phe Gln Glu Asp Asp Glu Xaa Glu 
                85                  90                  95      


Ala Glu Pro Leu Leu Phe Arg Ala Val Pro Glu Cys Gln Leu Ser Gly 
            100                 105                 110         


Gly Asp Ile Pro Ser Val Ser Glu Glu Gln Glu Ser Ser Glu Gly Gln 
        115                 120                 125             


Asp Ser Gly Asp Ile Cys Ser Glu Glu Asn Gln Ile Val Ser Ser Tyr 
    130                 135                 140                 


Ala Ser Lys Val Cys Phe Glu Ile Glu Glu Asp Tyr Lys Asn Arg Gln 
145                 150                 155                 160 


Phe Leu Gly Pro Glu Gly Asn Val Asp Val Glu Leu Ile Asp Lys Ser 
                165                 170                 175     


Xaa Asn Arg Tyr Ser Val Trp Phe Pro Xaa Ala Gly Trp Tyr Leu Trp 
            180                 185                 190         


Ser Ala Xaa Gly Leu Gly Phe Leu Val Arg Asp Glu Val Xaa Val Xaa 
        195                 200                 205             


Ile Ala Phe Gly Ser Trp Ser Gln His Leu Ala Leu Asp Leu Gln His 
    210                 215                 220                 


His Glu Gln Trp Leu Val Gly Gly Pro Leu Phe Asp Val Xaa Ala Glu 
225                 230                 235                 240 


Pro Glu Glu Ala Val Ala Glu Ile His Leu Pro His Phe Ile Ser Leu 
                245                 250                 255     


Gln Ala Gly Glu Val Asp Val Ser Trp Phe Leu Val Ala His Phe Lys 
            260                 265                 270         


Asn Glu Gly Met Val Leu Glu His Pro Ala Arg Val Glu Pro Phe Tyr 
        275                 280                 285             


Ala Val Leu Glu Ser Pro Ser Phe Ser Leu Met Gly Ile Leu Leu Arg 
    290                 295                 300                 


Ile Ala Ser Gly Xaa Arg Leu Ser Ile Pro Ile Xaa Ser Asn Xaa Leu 
305                 310                 315                 320 


Ile Tyr Tyr His Pro His Pro Glu Asp Ile Lys Phe His Leu Tyr Leu 
                325                 330                 335     


Val Pro Ser Asp Ala Leu Leu Xaa Lys Ala Ile Asp Asp Glu Glu Asp 
            340                 345                 350         


Arg Phe His Gly Val Arg Leu Gln Xaa Ser Pro Pro Met Glu Pro Leu 
        355                 360                 365             


Asn Phe Gly Ser Ser Tyr Ile Val Ser Asn Ser Ala Asn Leu Lys Val 
    370                 375                 380                 


Met Pro Lys Trp Ile Ser Ser Leu 
385                 390         


<210> 4980
<211> 537
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<400> 4980
Met Glu Lys Lys Glu Cys Pro Glu Lys Ser Ser Ser Ser Glu Glu Glu 
1               5                   10                  15      


Leu Pro Arg Arg Asp Ser Gly Ser Ser Arg Asn Ile Asp Ala Ser Lys 
            20                  25                  30          


Leu Ile Arg Leu Gln Gly Ser Arg Lys Leu Leu Val Asp Asn Ser Ile 
        35                  40                  45              


Arg Glu Leu Gln Tyr Xaa Lys Xaa Gly Ile Phe Phe Gln Ala Glu Ala 
    50                  55                  60                  


Cys Val Xaa Asn Asp Xaa Val Tyr Arg Glu Leu Pro Cys Val Ser Glu 
65                  70                  75                  80  


Xaa Leu Cys Asp Ile Ser His Phe Phe Gln Glu Asp Asp Glu Xaa Glu 
                85                  90                  95      


Ala Glu Pro Leu Leu Phe Arg Ala Val Pro Glu Cys Gln Leu Ser Gly 
            100                 105                 110         


Gly Asp Ile Pro Ser Val Ser Glu Glu Gln Glu Ser Ser Glu Gly Gln 
        115                 120                 125             


Asp Ser Gly Asp Ile Cys Ser Glu Glu Asn Gln Ile Val Ser Ser Tyr 
    130                 135                 140                 


Ala Ser Lys Val Cys Phe Glu Ile Glu Glu Asp Tyr Lys Asn Arg Gln 
145                 150                 155                 160 


Phe Leu Gly Pro Glu Gly Asn Val Asp Val Glu Leu Ile Asp Lys Ser 
                165                 170                 175     


Xaa Asn Arg Tyr Ser Val Trp Phe Pro Xaa Ala Gly Trp Tyr Leu Trp 
            180                 185                 190         


Ser Ala Xaa Gly Leu Gly Phe Leu Val Arg Asp Glu Val Xaa Val Xaa 
        195                 200                 205             


Ile Ala Phe Gly Ser Trp Ser Gln His Leu Ala Leu Asp Leu Gln His 
    210                 215                 220                 


His Glu Gln Trp Leu Val Gly Gly Pro Leu Phe Asp Val Xaa Ala Glu 
225                 230                 235                 240 


Pro Glu Glu Ala Val Ala Glu Ile His Leu Pro His Phe Ile Ser Leu 
                245                 250                 255     


Gln Ala Gly Glu Val Asp Val Ser Trp Phe Leu Val Ala His Phe Lys 
            260                 265                 270         


Asn Glu Gly Met Val Leu Glu His Pro Ala Arg Val Glu Pro Phe Tyr 
        275                 280                 285             


Ala Val Leu Glu Ser Pro Ser Phe Ser Leu Met Gly Ile Leu Leu Arg 
    290                 295                 300                 


Ile Ala Ser Gly Xaa Arg Leu Ser Ile Pro Ile Xaa Ser Asn Xaa Leu 
305                 310                 315                 320 


Ile Tyr Tyr His Pro His Pro Glu Asp Ile Lys Phe His Leu Tyr Leu 
                325                 330                 335     


Val Pro Ser Asp Ala Leu Leu Xaa Lys Ala Ile Asp Asp Glu Glu Asp 
            340                 345                 350         


Arg Phe His Gly Val Arg Leu Gln Xaa Ser Pro Pro Met Glu Pro Leu 
        355                 360                 365             


Asn Phe Gly Ser Ser Tyr Ile Val Ser Asn Ser Ala Asn Leu Lys Val 
    370                 375                 380                 


Met Pro Lys Glu Leu Lys Leu Ser Tyr Arg Ser Pro Gly Glu Ile Gln 
385                 390                 395                 400 


His Phe Ser Lys Phe Tyr Ala Gly Gln Met Lys Glu Pro Ile Gln Leu 
                405                 410                 415     


Glu Ile Xaa Glu Lys Arg His Gly Xaa Leu Val Trp Asp Xaa Glu Val 
            420                 425                 430         


Lys Pro Val Asp Leu Gln Leu Val Ala Ala Ser Ala Pro Pro Pro Phe 
        435                 440                 445             


Ser Gly Ala Ala Phe Val Lys Glu Asn His Arg Gln Leu Gln Ala Arg 
    450                 455                 460                 


Met Gly Asp Leu Lys Gly Val Leu Asp Asp Leu Gln Asp Asn Glu Val 
465                 470                 475                 480 


Leu Xaa Glu Asn Glu Lys Glu Leu Val Glu Gln Glu Lys Xaa Arg Gln 
                485                 490                 495     


Ser Lys Asn Glu Ala Leu Leu Ser Met Val Glu Lys Lys Gly Asp Leu 
            500                 505                 510         


Ala Leu Asp Val Leu Phe Arg Ser Ile Ser Glu Arg Asp Pro Tyr Leu 
        515                 520                 525             


Val Ser Tyr Leu Arg Gln Gln Asn Leu 
    530                 535         


<210> 4981
<211> 43
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<400> 4981
Met Glu Lys Lys Glu Cys Pro Glu Lys Ser Ser Ser Ser Glu Glu Glu 
1               5                   10                  15      


Leu Pro Arg Arg Val Tyr Arg Glu Leu Pro Cys Val Ser Glu Xaa Leu 
            20                  25                  30          


Cys Asp Ile Ser His Phe Phe Gln Glu Asp Asp 
        35                  40              


<210> 4982
<211> 82
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<400> 4982
Met Glu Lys Lys Glu Cys Pro Glu Lys Ser Ser Ser Ser Glu Glu Glu 
1               5                   10                  15      


Leu Pro Arg Arg Val Tyr Arg Glu Leu Pro Cys Val Ser Glu Xaa Leu 
            20                  25                  30          


Cys Asp Ile Ser His Phe Phe Gln Glu Asp Asp Glu Xaa Glu Ala Glu 
        35                  40                  45              


Pro Leu Leu Phe Arg Ala Val Pro Glu Cys Gln Leu Ser Gly Gly Asp 
    50                  55                  60                  


Ile Pro Arg Arg His Leu Leu Arg Arg Glu Ser Asn Ser Phe Leu Leu 
65                  70                  75                  80  


Cys Phe 
        


<210> 4983
<211> 132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 4983
Met Glu Lys Lys Glu Cys Pro Glu Lys Ser Ser Ser Ser Glu Glu Glu 
1               5                   10                  15      


Leu Pro Arg Arg Val Tyr Arg Glu Leu Pro Cys Val Ser Glu Xaa Leu 
            20                  25                  30          


Cys Asp Ile Ser His Phe Phe Gln Glu Asp Asp Glu Xaa Glu Ala Glu 
        35                  40                  45              


Pro Leu Leu Phe Arg Ala Val Pro Glu Cys Gln Leu Ser Gly Gly Asp 
    50                  55                  60                  


Ile Pro Ser Val Ser Glu Glu Gln Glu Ser Ser Glu Gly Gln Asp Ser 
65                  70                  75                  80  


Gly Asp Ile Cys Ser Glu Glu Asn Gln Ile Val Ser Ser Tyr Ala Ser 
                85                  90                  95      


Lys Val Cys Phe Glu Ile Glu Glu Asp Tyr Lys Asn Arg Gln Phe Leu 
            100                 105                 110         


Gly Pro Glu Gly Asn Val Asp Val Glu Leu Ile Asp Lys Ser Xaa Asn 
        115                 120                 125             


Arg Tyr Arg Arg 
    130         


<210> 4984
<211> 487
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<400> 4984
Met Glu Lys Lys Glu Cys Pro Glu Lys Ser Ser Ser Ser Glu Glu Glu 
1               5                   10                  15      


Leu Pro Arg Arg Val Tyr Arg Glu Leu Pro Cys Val Ser Glu Xaa Leu 
            20                  25                  30          


Cys Asp Ile Ser His Phe Phe Gln Glu Asp Asp Glu Xaa Glu Ala Glu 
        35                  40                  45              


Pro Leu Leu Phe Arg Ala Val Pro Glu Cys Gln Leu Ser Gly Gly Asp 
    50                  55                  60                  


Ile Pro Ser Val Ser Glu Glu Gln Glu Ser Ser Glu Gly Gln Asp Ser 
65                  70                  75                  80  


Gly Asp Ile Cys Ser Glu Glu Asn Gln Ile Val Ser Ser Tyr Ala Ser 
                85                  90                  95      


Lys Val Cys Phe Glu Ile Glu Glu Asp Tyr Lys Asn Arg Gln Phe Leu 
            100                 105                 110         


Gly Pro Glu Gly Asn Val Asp Val Glu Leu Ile Asp Lys Ser Xaa Asn 
        115                 120                 125             


Arg Tyr Ser Val Trp Phe Pro Xaa Ala Gly Trp Tyr Leu Trp Ser Ala 
    130                 135                 140                 


Xaa Gly Leu Gly Phe Leu Val Arg Asp Glu Val Xaa Val Xaa Ile Ala 
145                 150                 155                 160 


Phe Gly Ser Trp Ser Gln His Leu Ala Leu Asp Leu Gln His His Glu 
                165                 170                 175     


Gln Trp Leu Val Gly Gly Pro Leu Phe Asp Val Xaa Ala Glu Pro Glu 
            180                 185                 190         


Glu Ala Val Ala Glu Ile His Leu Pro His Phe Ile Ser Leu Gln Ala 
        195                 200                 205             


Gly Glu Val Asp Val Ser Trp Phe Leu Val Ala His Phe Lys Asn Glu 
    210                 215                 220                 


Gly Met Val Leu Glu His Pro Ala Arg Val Glu Pro Phe Tyr Ala Val 
225                 230                 235                 240 


Leu Glu Ser Pro Ser Phe Ser Leu Met Gly Ile Leu Leu Arg Ile Ala 
                245                 250                 255     


Ser Gly Xaa Arg Leu Ser Ile Pro Ile Xaa Ser Asn Xaa Leu Ile Tyr 
            260                 265                 270         


Tyr His Pro His Pro Glu Asp Ile Lys Phe His Leu Tyr Leu Val Pro 
        275                 280                 285             


Ser Asp Ala Leu Leu Xaa Lys Ala Ile Asp Asp Glu Glu Asp Arg Phe 
    290                 295                 300                 


His Gly Val Arg Leu Gln Xaa Ser Pro Pro Met Glu Pro Leu Asn Phe 
305                 310                 315                 320 


Gly Ser Ser Tyr Ile Val Ser Asn Ser Ala Asn Leu Lys Val Met Pro 
                325                 330                 335     


Lys Glu Leu Lys Leu Ser Tyr Arg Ser Pro Gly Glu Ile Gln His Phe 
            340                 345                 350         


Ser Lys Phe Tyr Ala Gly Gln Met Lys Glu Pro Ile Gln Leu Glu Ile 
        355                 360                 365             


Xaa Glu Lys Arg His Gly Xaa Leu Val Trp Asp Xaa Glu Val Lys Pro 
    370                 375                 380                 


Val Asp Leu Gln Leu Val Ala Ala Ser Ala Pro Pro Pro Phe Ser Gly 
385                 390                 395                 400 


Ala Ala Phe Val Lys Glu Asn His Arg Gln Leu Gln Ala Arg Met Gly 
                405                 410                 415     


Asp Leu Lys Gly Val Leu Asp Asp Leu Gln Asp Asn Glu Val Leu Xaa 
            420                 425                 430         


Glu Asn Glu Lys Glu Leu Val Glu Gln Glu Lys Xaa Arg Gln Ser Lys 
        435                 440                 445             


Asn Glu Ala Leu Leu Ser Met Val Glu Lys Lys Gly Asp Leu Ala Leu 
    450                 455                 460                 


Asp Val Leu Phe Arg Ser Ile Ser Glu Arg Asp Pro Tyr Leu Val Ser 
465                 470                 475                 480 


Tyr Leu Arg Gln Gln Asn Leu 
                485         


<210> 4985
<211> 283
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<400> 4985
Met Xaa Arg Asn Ile Leu Val Pro Phe Phe Val Trp Ile Gln Arg Ser 
1               5                   10                  15      


Glu Xaa Ala Tyr Ser Gly His Ser Gln Leu Ser Phe Asp Ile Cys Ile 
            20                  25                  30          


Pro Xaa Ala Pro Val Gln Phe Ser Leu Gln Glu Ser Phe Arg Pro Cys 
        35                  40                  45              


Leu Phe Gln Pro Phe Xaa Ser Tyr Met Ser Ser Ile Phe Phe Ser Gly 
    50                  55                  60                  


Asp Ile Cys Ser Glu Glu Asn Gln Ile Val Ser Ser Tyr Ala Ser Lys 
65                  70                  75                  80  


Val Cys Phe Glu Ile Glu Glu Asp Tyr Lys Asn Arg Gln Phe Leu Gly 
                85                  90                  95      


Pro Glu Gly Asn Val Asp Val Glu Leu Ile Asp Lys Ser Xaa Asn Arg 
            100                 105                 110         


Tyr Ser Val Trp Phe Pro Xaa Ala Gly Trp Tyr Leu Trp Ser Ala Xaa 
        115                 120                 125             


Gly Leu Gly Phe Leu Val Arg Asp Glu Val Xaa Val Xaa Ile Ala Phe 
    130                 135                 140                 


Gly Ser Trp Ser Gln His Leu Ala Leu Asp Leu Gln His His Glu Gln 
145                 150                 155                 160 


Trp Leu Val Gly Gly Pro Leu Phe Asp Val Xaa Ala Glu Pro Glu Glu 
                165                 170                 175     


Ala Val Ala Glu Ile His Leu Pro His Phe Ile Ser Leu Gln Ala Gly 
            180                 185                 190         


Glu Val Asp Val Ser Trp Phe Leu Val Ala His Phe Lys Asn Glu Gly 
        195                 200                 205             


Met Val Leu Glu His Pro Ala Arg Val Glu Pro Phe Tyr Ala Val Leu 
    210                 215                 220                 


Glu Ser Pro Ser Phe Ser Leu Met Gly Ile Leu Leu Arg Ile Ala Ser 
225                 230                 235                 240 


Gly Xaa Arg Leu Ser Ile Pro Ile Xaa Ser Asn Xaa Leu Ile Tyr Tyr 
                245                 250                 255     


His Pro His Pro Glu Asp Ile Lys Phe His Leu Tyr Leu Val Pro Ser 
            260                 265                 270         


Asp Ala Leu Leu Xaa Lys Val Arg Gln Ser Leu 
        275                 280             


<210> 4986
<211> 70
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<400> 4986
Xaa Gly Gln Met Lys Glu Pro Ile Gln Leu Glu Ile Xaa Glu Lys Arg 
1               5                   10                  15      


His Gly Xaa Leu Val Trp Asp Xaa Glu Val Lys Pro Val Asp Leu Gln 
            20                  25                  30          


Leu Val Ala Ala Ser Ala Pro Pro Pro Phe Ser Gly Val Arg Met Trp 
        35                  40                  45              


Pro Gly Cys Cys Pro Ile Leu Pro Arg Xaa Gly Cys Xaa Cys Leu Cys 
    50                  55                  60                  


Leu Asn Pro Trp Leu Pro 
65                  70  


<210> 4987
<211> 24
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<400> 4987
Xaa His Pro Glu Asp Ile Lys Phe His Leu Tyr Leu Val Pro Ser Asp 
1               5                   10                  15      


Ala Leu Leu Xaa Lys Xaa Leu Phe 
            20                  


<210> 4988
<211> 366
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<400> 4988
Met Ser Asp Tyr Glu Asn Asp Asp Glu Cys Trp Ser Val Leu Glu Gly 
1               5                   10                  15      


Phe Arg Val Xaa Leu Xaa Ser Val Ile Asp Pro Ser Arg Ile Xaa Pro 
            20                  25                  30          


Tyr Leu Arg Gln Cys Lys Val Leu Asn Pro Asp Asp Glu Glu Gln Val 
        35                  40                  45              


Leu Ser Asp Pro Asn Leu Val Ile Arg Lys Arg Lys Val Gly Val Leu 
    50                  55                  60                  


Leu Asp Ile Leu Gln Arg Xaa Gly His Lys Gly Tyr Val Ala Phe Leu 
65                  70                  75                  80  


Glu Ser Leu Glu Leu Tyr Tyr Pro Gln Leu Tyr Lys Lys Val Xaa Gly 
                85                  90                  95      


Lys Glu Pro Ala Arg Val Phe Ser Met Ile Ile Asp Ala Ser Gly Glu 
            100                 105                 110         


Ser Gly Leu Xaa Gln Leu Leu Met Xaa Glu Val Met Lys Leu Gln Lys 
        115                 120                 125             


Lys Val Gln Asp Leu Xaa Ala Leu Leu Ser Ser Lys Asp Asp Phe Ile 
    130                 135                 140                 


Lys Glu Leu Arg Val Lys Asp Ser Leu Leu Arg Lys His Gln Glu Arg 
145                 150                 155                 160 


Val Gln Arg Leu Lys Glu Glu Cys Glu Ala Gly Ser Arg Glu Leu Lys 
                165                 170                 175     


Arg Cys Lys Glu Glu Asn Tyr Asp Leu Ala Met Arg Leu Ala His Gln 
            180                 185                 190         


Ser Glu Glu Lys Gly Ala Ala Leu Met Arg Asn Arg Asp Leu Gln Leu 
        195                 200                 205             


Glu Ile Asp Gln Leu Lys His Ser Leu Met Lys Ala Glu Asp Asp Cys 
    210                 215                 220                 


Lys Val Glu Arg Lys His Xaa Leu Lys Leu Arg His Ala Met Glu Gln 
225                 230                 235                 240 


Arg Pro Ser Gln Glu Leu Leu Trp Glu Leu Gln Gln Glu Lys Ala Leu 
                245                 250                 255     


Leu Gln Ala Arg Val Gln Glu Leu Glu Ala Ser Val Gln Glu Gly Lys 
            260                 265                 270         


Leu Asp Arg Ser Ser Pro Tyr Ile Gln Val Leu Glu Glu Asp Trp Arg 
        275                 280                 285             


Gln Ala Leu Arg Asp His Gln Glu Gln Ala Asn Xaa Ile Phe Ser Leu 
    290                 295                 300                 


Arg Lys Asp Leu Arg Gln Gly Glu Ala Arg Arg Leu Arg Cys Met Glu 
305                 310                 315                 320 


Glu Lys Glu Met Phe Glu Leu Gln Cys Leu Ala Leu Arg Lys Asp Ser 
                325                 330                 335     


Lys Met Tyr Lys Asp Arg Ile Glu Ala Ile Leu Leu Gln Met Glu Glu 
            340                 345                 350         


Val Ala Ile Glu Arg Asp Gln Ser Xaa Gln Met Glu Gly Leu 
        355                 360                 365     


<210> 4989
<211> 492
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<400> 4989
Met Ser Asp Tyr Glu Asn Asp Asp Glu Cys Trp Ser Val Leu Glu Gly 
1               5                   10                  15      


Phe Arg Val Xaa Leu Xaa Ser Val Ile Asp Pro Ser Arg Ile Xaa Pro 
            20                  25                  30          


Tyr Leu Arg Gln Cys Lys Val Leu Asn Pro Asp Asp Glu Glu Gln Val 
        35                  40                  45              


Leu Ser Asp Pro Asn Leu Val Ile Arg Lys Arg Lys Val Gly Val Leu 
    50                  55                  60                  


Leu Asp Ile Leu Gln Arg Xaa Gly His Lys Gly Tyr Val Ala Phe Leu 
65                  70                  75                  80  


Glu Ser Leu Glu Leu Tyr Tyr Pro Gln Leu Tyr Lys Lys Val Xaa Gly 
                85                  90                  95      


Lys Glu Pro Ala Arg Val Phe Ser Met Ile Ile Asp Ala Ser Gly Glu 
            100                 105                 110         


Ser Gly Leu Xaa Gln Leu Leu Met Xaa Glu Val Met Lys Leu Gln Lys 
        115                 120                 125             


Lys Val Gln Asp Leu Xaa Ala Leu Leu Ser Ser Lys Asp Asp Phe Ile 
    130                 135                 140                 


Lys Glu Leu Arg Val Lys Asp Ser Leu Leu Arg Lys His Gln Glu Arg 
145                 150                 155                 160 


Val Gln Arg Leu Lys Glu Glu Cys Glu Ala Gly Ser Arg Glu Leu Lys 
                165                 170                 175     


Arg Cys Lys Glu Glu Asn Tyr Asp Leu Ala Met Arg Leu Ala His Gln 
            180                 185                 190         


Ser Glu Glu Lys Gly Ala Ala Leu Met Arg Asn Arg Asp Leu Gln Leu 
        195                 200                 205             


Glu Ile Asp Gln Leu Lys His Ser Leu Met Lys Ala Glu Asp Asp Cys 
    210                 215                 220                 


Lys Val Glu Arg Lys His Xaa Leu Lys Leu Arg His Ala Met Glu Gln 
225                 230                 235                 240 


Arg Pro Ser Gln Glu Leu Leu Trp Glu Leu Gln Gln Glu Lys Ala Leu 
                245                 250                 255     


Leu Gln Ala Arg Val Gln Glu Leu Glu Ala Ser Val Gln Glu Gly Lys 
            260                 265                 270         


Leu Asp Arg Ser Ser Pro Tyr Ile Gln Val Leu Glu Glu Asp Trp Arg 
        275                 280                 285             


Gln Ala Leu Arg Asp His Gln Glu Gln Ala Asn Xaa Ile Phe Ser Leu 
    290                 295                 300                 


Arg Lys Asp Leu Arg Gln Gly Glu Ala Arg Arg Leu Arg Cys Met Glu 
305                 310                 315                 320 


Glu Lys Glu Met Phe Glu Leu Gln Cys Leu Ala Leu Arg Lys Asp Ser 
                325                 330                 335     


Lys Met Tyr Lys Asp Arg Ile Glu Ala Ile Leu Leu Gln Met Glu Glu 
            340                 345                 350         


Val Ala Ile Glu Arg Asp Gln Ala Ile Ala Xaa Arg Glu Glu Leu His 
        355                 360                 365             


Ala Gln His Ala Arg Gly Leu Gln Glu Lys Asp Ala Leu Arg Lys Gln 
    370                 375                 380                 


Val Arg Glu Leu Gly Glu Lys Ala Asp Glu Leu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Gln Cys Glu Ala Gln Leu Leu Ala Val Glu Gly Arg Leu Arg Arg Gln 
                405                 410                 415     


Gln Leu Glu Xaa Leu Val Leu Ser Ser Asp Leu Glu Asp Gly Ser Pro 
            420                 425                 430         


Arg Arg Ser Gln Glu Leu Ser Leu Pro Gln Asp Leu Glu Asp Xaa Gln 
        435                 440                 445             


Leu Ser Asp Lys Gly Cys Leu Ala Gly Gly Gly Ser Pro Lys Gln Pro 
    450                 455                 460                 


Phe Ala Ala Leu His Gln Glu Gln Val Leu Arg Asn Pro His Asp Ala 
465                 470                 475                 480 


Gly Pro Ala Gly Leu Pro Gly Ile Gly Ala Val Cys 
                485                 490         


<210> 4990
<211> 536
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<400> 4990
Met Ser Asp Tyr Glu Asn Asp Asp Glu Cys Trp Ser Val Leu Glu Gly 
1               5                   10                  15      


Phe Arg Val Xaa Leu Xaa Ser Val Ile Asp Pro Ser Arg Ile Xaa Pro 
            20                  25                  30          


Tyr Leu Arg Gln Cys Lys Val Leu Asn Pro Asp Asp Glu Glu Gln Val 
        35                  40                  45              


Leu Ser Asp Pro Asn Leu Val Ile Arg Lys Arg Lys Val Gly Val Leu 
    50                  55                  60                  


Leu Asp Ile Leu Gln Arg Xaa Gly His Lys Gly Tyr Val Ala Phe Leu 
65                  70                  75                  80  


Glu Ser Leu Glu Leu Tyr Tyr Pro Gln Leu Tyr Lys Lys Val Xaa Gly 
                85                  90                  95      


Lys Glu Pro Ala Arg Val Phe Ser Met Ile Ile Asp Ala Ser Gly Glu 
            100                 105                 110         


Ser Gly Leu Xaa Gln Leu Leu Met Xaa Glu Val Met Lys Leu Gln Lys 
        115                 120                 125             


Lys Val Gln Asp Leu Xaa Ala Leu Leu Ser Ser Lys Asp Asp Phe Ile 
    130                 135                 140                 


Lys Glu Leu Arg Val Lys Asp Ser Leu Leu Arg Lys His Gln Glu Arg 
145                 150                 155                 160 


Val Gln Arg Leu Lys Glu Glu Cys Glu Ala Gly Ser Arg Glu Leu Lys 
                165                 170                 175     


Arg Cys Lys Glu Glu Asn Tyr Asp Leu Ala Met Arg Leu Ala His Gln 
            180                 185                 190         


Ser Glu Glu Lys Gly Ala Ala Leu Met Arg Asn Arg Asp Leu Gln Leu 
        195                 200                 205             


Glu Ile Asp Gln Leu Lys His Ser Leu Met Lys Ala Glu Asp Asp Cys 
    210                 215                 220                 


Lys Val Glu Arg Lys His Xaa Leu Lys Leu Arg His Ala Met Glu Gln 
225                 230                 235                 240 


Arg Pro Ser Gln Glu Leu Leu Trp Glu Leu Gln Gln Glu Lys Ala Leu 
                245                 250                 255     


Leu Gln Ala Arg Val Gln Glu Leu Glu Ala Ser Val Gln Glu Gly Lys 
            260                 265                 270         


Leu Asp Arg Ser Ser Pro Tyr Ile Gln Val Leu Glu Glu Asp Trp Arg 
        275                 280                 285             


Gln Ala Leu Arg Asp His Gln Glu Gln Ala Asn Xaa Ile Phe Ser Leu 
    290                 295                 300                 


Arg Lys Asp Leu Arg Gln Gly Glu Ala Arg Arg Leu Arg Cys Met Glu 
305                 310                 315                 320 


Glu Lys Glu Met Phe Glu Leu Gln Cys Leu Ala Leu Arg Lys Asp Ser 
                325                 330                 335     


Lys Met Tyr Lys Asp Arg Ile Glu Ala Ile Leu Leu Gln Met Glu Glu 
            340                 345                 350         


Val Ala Ile Glu Arg Asp Gln Ala Ile Ala Xaa Arg Glu Glu Leu His 
        355                 360                 365             


Ala Gln His Ala Arg Gly Leu Gln Glu Lys Asp Ala Leu Arg Lys Gln 
    370                 375                 380                 


Val Arg Glu Leu Gly Glu Lys Ala Asp Glu Leu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Gln Cys Glu Ala Gln Leu Leu Ala Val Glu Gly Arg Leu Arg Arg Gln 
                405                 410                 415     


Gln Leu Glu Xaa Leu Val Leu Ser Ser Asp Leu Glu Asp Gly Ser Pro 
            420                 425                 430         


Arg Arg Ser Gln Glu Leu Ser Leu Pro Gln Asp Leu Glu Asp Xaa Gln 
        435                 440                 445             


Leu Ser Asp Lys Gly Cys Leu Ala Gly Gly Gly Ser Pro Lys Gln Pro 
    450                 455                 460                 


Phe Ala Ala Leu His Gln Glu Gln Val Leu Arg Asn Pro His Asp Ala 
465                 470                 475                 480 


Gly Leu Ser Ser Gly Glu Pro Pro Glu Lys Glu Arg Arg Arg Leu Lys 
                485                 490                 495     


Glu Ser Phe Glu Asn Tyr Arg Arg Lys Arg Ala Leu Arg Lys Met Gln 
            500                 505                 510         


Lys Gly Trp Arg Gln Gly Glu Glu Asp Arg Glu Asn Xaa Xaa Gly Ser 
        515                 520                 525             


Asp Asn Xaa Asp Xaa Glu Gly Ser 
    530                 535     


<210> 4991
<211> 38
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<400> 4991
Met Asp Ser Arg Asp Ser Ser Phe Gly Gln Asn Asp Ser Pro Xaa Val 
1               5                   10                  15      


Leu Pro Ile Xaa Xaa Arg Glu Ala Asn Asn Ser Leu Ile Ser Gln Asn 
            20                  25                  30          


Ile Pro Gly Pro Leu Xaa 
        35              


<210> 4992
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<400> 4992
Met Asp Ser Arg Asp Ser Ser Phe Gly Gln Asn Asp Ser Pro Xaa Val 
1               5                   10                  15      


Leu Pro Ile Xaa Xaa Arg Glu Ala Asn Asn Ser Leu Ile Ser Gln Asn 
            20                  25                  30          


Ile Pro Gly Pro Leu Xaa Gln Xaa Gln Xaa Leu Ser Ala Glu Gln Phe 
        35                  40                  45              


His Leu Val Asp Gln Asn Gly Gln Ala Ile Gln Tyr Glu Leu Gln Ser 
    50                  55                  60                  


Leu Gly Glu Ser Asn Ala Gln Met Met Ile Val Ala Ser Pro Xaa Glu 
65                  70                  75                  80  


Asn Gly Gln Val Leu Arg Val Ile Pro Pro Xaa Gln Xaa 
                85                  90              


<210> 4993
<211> 189
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 4993
Met Asp Ser Arg Asp Ser Ser Phe Gly Gln Asn Asp Ser Pro Xaa Val 
1               5                   10                  15      


Leu Pro Ile Xaa Xaa Arg Glu Ala Asn Asn Ser Leu Ile Ser Gln Asn 
            20                  25                  30          


Ile Pro Gly Pro Leu Xaa Gln Xaa Gln Xaa Leu Ser Ala Glu Gln Phe 
        35                  40                  45              


His Leu Val Asp Gln Asn Gly Gln Ala Ile Gln Tyr Glu Leu Gln Ser 
    50                  55                  60                  


Leu Gly Glu Ser Asn Ala Gln Met Met Ile Val Ala Ser Pro Xaa Glu 
65                  70                  75                  80  


Asn Gly Gln Val Leu Arg Val Ile Pro Pro Xaa Gln Xaa Gly Met Ala 
                85                  90                  95      


Gln Val Ile Ile Pro Gln Gly Gln Leu Val Asp Val Asn Ser Pro Arg 
            100                 105                 110         


Asp Val Pro Glu Glu Lys Pro Ser Asn Arg Asn Leu Pro Xaa Val Arg 
        115                 120                 125             


Val Asp Xaa Leu Ala Asp Asn Xaa Ser Asn Tyr Ile Leu His Pro Gln 
    130                 135                 140                 


Xaa Ser Phe Pro Leu Pro Lys Lys Ser Val Xaa Gly Met Leu Glu Glu 
145                 150                 155                 160 


Pro Leu Leu Gly Pro Leu Gln Pro Leu Ser Ser Asn Xaa Pro Ile Trp 
                165                 170                 175     


Ala Cys Arg Leu Arg Ser Cys Glu Gly Val Glu Leu Trp 
            180                 185                 


<210> 4994
<211> 419
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<400> 4994
Met Asp Ser Arg Asp Ser Ser Phe Gly Gln Asn Asp Ser Pro Xaa Val 
1               5                   10                  15      


Leu Pro Ile Xaa Xaa Arg Glu Ala Asn Asn Ser Leu Ile Ser Gln Asn 
            20                  25                  30          


Ile Pro Gly Pro Leu Xaa Gln Xaa Gln Xaa Leu Ser Ala Glu Gln Phe 
        35                  40                  45              


His Leu Val Asp Gln Asn Gly Gln Ala Ile Gln Tyr Glu Leu Gln Ser 
    50                  55                  60                  


Leu Gly Glu Ser Asn Ala Gln Met Met Ile Val Ala Ser Pro Xaa Glu 
65                  70                  75                  80  


Asn Gly Gln Val Leu Arg Val Ile Pro Pro Xaa Gln Xaa Gly Met Ala 
                85                  90                  95      


Gln Val Ile Ile Pro Gln Gly Gln Leu Val Asp Val Asn Ser Pro Arg 
            100                 105                 110         


Asp Val Pro Glu Glu Lys Pro Ser Asn Arg Asn Leu Pro Xaa Val Arg 
        115                 120                 125             


Val Asp Xaa Leu Ala Asp Asn Xaa Ser Asn Tyr Ile Leu His Pro Gln 
    130                 135                 140                 


Xaa Ser Phe Pro Leu Pro Lys Lys Ser Val Xaa Gly Met Leu Glu Glu 
145                 150                 155                 160 


Pro Leu Leu Gly Pro Leu Gln Pro Leu Ser Ser Asn Xaa Pro Ile Trp 
                165                 170                 175     


Ala Cys Arg Leu Arg Ser Cys Glu Lys Ile Gly Asp Ser Tyr Arg Gly 
            180                 185                 190         


Tyr Cys Val Ser Glu Xaa Glu Leu Glu Ser Val Leu Xaa Phe His Lys 
        195                 200                 205             


Gln Gln Xaa Gln Ser Val Trp Gly Xaa Arg Gln Ser Pro Ser Pro Ala 
    210                 215                 220                 


Lys Pro Ala Xaa Arg Leu Met Trp Lys Ser Gln Tyr Val Pro Tyr Asp 
225                 230                 235                 240 


Gly Ile Pro Phe Val Asn Ala Gly Ser Arg Ala Val Val Met Glu Cys 
                245                 250                 255     


Gln Tyr Gly Pro Arg Arg Lys Gly Phe Gln Leu Lys Lys Val Ser Glu 
            260                 265                 270         


Gln Glu Ser Arg Ser Cys Gln Leu Tyr Lys Ala Xaa Cys Pro Ala Arg 
        275                 280                 285             


Ile Tyr Ile Lys Lys Val Gln Lys Phe Pro Glu Tyr Arg Val Pro Xaa 
    290                 295                 300                 


Asp Pro Lys Ile Asp Lys Lys Ile Ile Arg Met Glu Gln Glu Lys Ala 
305                 310                 315                 320 


Phe Asn Met Leu Lys Lys Asn Leu Val Asp Ala Gly Gly Val Leu Arg 
                325                 330                 335     


Trp Tyr Val Gln Leu Pro Xaa Gln Gln Ala His Gln Tyr His Glu Leu 
            340                 345                 350         


Glu Xaa Pro Cys Leu Xaa Leu Ser Pro Ser Pro Phe Pro Val Ser Ser 
        355                 360                 365             


Leu Glu Glu Glu Glu Xaa Ala Val Arg Asp Glu Asn Cys Ala Leu Pro 
    370                 375                 380                 


Ser Arg Leu His Pro Gln Val Ala His Lys Ile Gln Glu Leu Val Ser 
385                 390                 395                 400 


Gln Gly Ile Glu Gln Val Tyr Ala Val Arg Lys Gln Leu Ser Pro Ser 
                405                 410                 415     


Tyr Phe Ile 
            


<210> 4995
<211> 21
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<400> 4995
Met Glu Gln Ser Asn Asp Ser Leu Arg Val Asn His Asn Asp Gly Glu 
1               5                   10                  15      


Glu Ser Lys Xaa Ser 
            20      


<210> 4996
<211> 33
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<400> 4996
Met Glu Gln Ser Asn Asp Ser Leu Arg Val Asn His Asn Asp Gly Glu 
1               5                   10                  15      


Glu Ser Lys Xaa Ser Ala Gln Val Phe Glu Gly Phe Phe Leu Trp Xaa 
            20                  25                  30          


Lys 
    


<210> 4997
<211> 54
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(51)
<223> Selenocysteine

<400> 4997
Met Glu Gln Ser Asn Asp Ser Leu Arg Val Asn His Asn Asp Gly Glu 
1               5                   10                  15      


Glu Ser Lys Xaa Ser Ala Gln Val Phe Glu His Leu Ile Cys Met Asp 
            20                  25                  30          


Ser Arg Asp Ser Ser Phe Gly Gln Asn Asp Ser Pro Xaa Val Leu Pro 
        35                  40                  45              


Ile Xaa Xaa Arg Glu Ala 
    50                  


<210> 4998
<211> 73
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<400> 4998
Met Glu Gln Ser Asn Asp Ser Leu Arg Val Asn His Asn Asp Gly Glu 
1               5                   10                  15      


Glu Ser Lys Xaa Ser Ala Gln Val Phe Glu His Leu Ile Cys Met Asp 
            20                  25                  30          


Ser Arg Asp Ser Ser Phe Gly Gln Asn Asp Ser Pro Xaa Val Leu Pro 
        35                  40                  45              


Ile Xaa Xaa Arg Glu Ala Asn Asn Ser Leu Ile Ser Gln Asn Ile Pro 
    50                  55                  60                  


Gly Pro Leu Xaa Gln Xaa Gln Xaa Leu 
65                  70              


<210> 4999
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<400> 4999
Met Glu Gln Ser Asn Asp Ser Leu Arg Val Asn His Asn Asp Gly Glu 
1               5                   10                  15      


Glu Ser Lys Xaa Ser Ala Gln Val Phe Glu His Leu Ile Cys Met Asp 
            20                  25                  30          


Ser Arg Asp Ser Ser Phe Gly Gln Asn Asp Ser Pro Xaa Val Leu Pro 
        35                  40                  45              


Ile Xaa Xaa Arg Glu Ala Asn Asn Ser Leu Ile Ser Gln Asn Ile Pro 
    50                  55                  60                  


Gly Pro Leu Xaa Gln Xaa Gln Xaa Leu Ser Ala Glu Gln Phe His Leu 
65                  70                  75                  80  


Val Asp Gln Asn Gly Gln Ala Ile Gln Tyr Glu Leu Gln Ser Leu 
                85                  90                  95  


<210> 5000
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<400> 5000
Met Glu Gln Ser Asn Asp Ser Leu Arg Val Asn His Asn Asp Gly Glu 
1               5                   10                  15      


Glu Ser Lys Xaa Ser Ala Gln Val Phe Glu His Leu Ile Cys Met Asp 
            20                  25                  30          


Ser Arg Asp Ser Ser Phe Gly Gln Asn Asp Ser Pro Xaa Val Leu Pro 
        35                  40                  45              


Ile Xaa Xaa Arg Glu Ala Asn Asn Ser Leu Ile Ser Gln Asn Ile Pro 
    50                  55                  60                  


Gly Pro Leu Xaa Gln Xaa Gln Xaa Leu Ser Ala Glu Gln Phe His Leu 
65                  70                  75                  80  


Val Asp Gln Asn Gly Gln Ala Ile Gln Tyr Glu Leu Gln Ser Leu Gly 
                85                  90                  95      


Glu Ser Asn Ala Gln Met Met Ile Val Ala Ser Pro Xaa Glu Asn Gly 
            100                 105                 110         


Gln Val Leu Arg Val Ile Pro Pro Xaa Gln Xaa Gly Met Ala Gln Val 
        115                 120                 125             


Ile Ile Pro 
    130     


<210> 5001
<211> 309
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<400> 5001
Met Glu Gln Ser Asn Asp Ser Leu Arg Val Asn His Asn Asp Gly Glu 
1               5                   10                  15      


Glu Ser Lys Xaa Ser Ala Gln Val Phe Glu His Leu Ile Cys Met Asp 
            20                  25                  30          


Ser Arg Asp Ser Ser Phe Gly Gln Asn Asp Ser Pro Xaa Val Leu Pro 
        35                  40                  45              


Ile Xaa Xaa Arg Glu Ala Asn Asn Ser Leu Ile Ser Gln Asn Ile Pro 
    50                  55                  60                  


Gly Pro Leu Xaa Gln Xaa Gln Xaa Leu Ser Ala Glu Gln Phe His Leu 
65                  70                  75                  80  


Val Asp Gln Asn Gly Gln Ala Ile Gln Tyr Glu Leu Gln Ser Leu Gly 
                85                  90                  95      


Glu Ser Asn Ala Gln Met Met Ile Val Ala Ser Pro Xaa Glu Asn Gly 
            100                 105                 110         


Gln Val Leu Arg Val Ile Pro Pro Xaa Gln Xaa Gly Met Ala Gln Val 
        115                 120                 125             


Ile Ile Pro Gln Gly Gln Leu Val Asp Val Asn Ser Pro Arg Asp Val 
    130                 135                 140                 


Pro Glu Glu Lys Pro Ser Asn Arg Asn Leu Pro Xaa Val Arg Val Asp 
145                 150                 155                 160 


Xaa Leu Ala Asp Asn Xaa Ser Asn Tyr Ile Leu His Pro Gln Xaa Ser 
                165                 170                 175     


Phe Pro Leu Pro Lys Lys Ser Val Xaa Gly Met Leu Glu Glu Pro Leu 
            180                 185                 190         


Leu Gly Pro Leu Gln Pro Leu Ser Ser Asn Xaa Pro Ile Trp Ala Cys 
        195                 200                 205             


Arg Leu Arg Ser Cys Glu Lys Ile Gly Asp Ser Tyr Arg Gly Tyr Cys 
    210                 215                 220                 


Val Ser Glu Xaa Glu Leu Glu Ser Val Leu Xaa Phe His Lys Gln Gln 
225                 230                 235                 240 


Xaa Gln Ser Val Trp Gly Xaa Arg Gln Ser Pro Ser Pro Ala Lys Pro 
                245                 250                 255     


Ala Xaa Arg Leu Met Trp Lys Ser Gln Tyr Val Pro Tyr Asp Gly Ile 
            260                 265                 270         


Pro Phe Val Asn Ala Gly Xaa Phe Leu Lys Asn Tyr Phe Lys Arg Phe 
        275                 280                 285             


Ser Ser Ser His Ser Pro Leu Ser Lys Cys Asp Phe Pro Lys Val Ile 
    290                 295                 300                 


Xaa Phe Leu Phe Trp 
305                 


<210> 5002
<211> 725
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<400> 5002
Met Glu Gln Ser Asn Asp Ser Leu Arg Val Asn His Asn Asp Gly Glu 
1               5                   10                  15      


Glu Ser Lys Xaa Ser Ala Gln Val Phe Glu His Leu Ile Cys Met Asp 
            20                  25                  30          


Ser Arg Asp Ser Ser Phe Gly Gln Asn Asp Ser Pro Xaa Val Leu Pro 
        35                  40                  45              


Ile Xaa Xaa Arg Glu Ala Asn Asn Ser Leu Ile Ser Gln Asn Ile Pro 
    50                  55                  60                  


Gly Pro Leu Xaa Gln Xaa Gln Xaa Leu Ser Ala Glu Gln Phe His Leu 
65                  70                  75                  80  


Val Asp Gln Asn Gly Gln Ala Ile Gln Tyr Glu Leu Gln Ser Leu Gly 
                85                  90                  95      


Glu Ser Asn Ala Gln Met Met Ile Val Ala Ser Pro Xaa Glu Asn Gly 
            100                 105                 110         


Gln Val Leu Arg Val Ile Pro Pro Xaa Gln Xaa Gly Met Ala Gln Val 
        115                 120                 125             


Ile Ile Pro Gln Gly Gln Leu Val Asp Val Asn Ser Pro Arg Asp Val 
    130                 135                 140                 


Pro Glu Glu Lys Pro Ser Asn Arg Asn Leu Pro Xaa Val Arg Val Asp 
145                 150                 155                 160 


Xaa Leu Ala Asp Asn Xaa Ser Asn Tyr Ile Leu His Pro Gln Xaa Ser 
                165                 170                 175     


Phe Pro Leu Pro Lys Lys Ser Val Xaa Gly Met Leu Glu Glu Pro Leu 
            180                 185                 190         


Leu Gly Pro Leu Gln Pro Leu Ser Ser Asn Xaa Pro Ile Trp Ala Cys 
        195                 200                 205             


Arg Leu Arg Ser Cys Glu Lys Ile Gly Asp Ser Tyr Arg Gly Tyr Cys 
    210                 215                 220                 


Val Ser Glu Xaa Glu Leu Glu Ser Val Leu Xaa Phe His Lys Gln Gln 
225                 230                 235                 240 


Xaa Gln Ser Val Trp Gly Xaa Arg Gln Ser Pro Ser Pro Ala Lys Pro 
                245                 250                 255     


Ala Xaa Arg Leu Met Trp Lys Ser Gln Tyr Val Pro Tyr Asp Gly Ile 
            260                 265                 270         


Pro Phe Val Asn Ala Gly Ser Arg Ala Val Val Met Glu Cys Gln Tyr 
        275                 280                 285             


Gly Pro Arg Arg Lys Gly Phe Gln Leu Lys Lys Val Ser Glu Gln Glu 
    290                 295                 300                 


Ser Arg Ser Cys Gln Leu Tyr Lys Ala Xaa Cys Pro Ala Arg Ile Tyr 
305                 310                 315                 320 


Ile Lys Lys Val Gln Lys Phe Pro Glu Tyr Arg Val Pro Xaa Asp Pro 
                325                 330                 335     


Lys Ile Asp Lys Lys Ile Ile Arg Met Glu Gln Glu Lys Ala Phe Asn 
            340                 345                 350         


Met Leu Lys Lys Asn Leu Val Asp Ala Gly Gly Val Leu Arg Trp Tyr 
        355                 360                 365             


Val Gln Leu Pro Xaa Gln Gln Ala His Gln Tyr His Glu Leu Glu Xaa 
    370                 375                 380                 


Pro Cys Leu Xaa Leu Ser Pro Ser Pro Phe Pro Val Ser Ser Leu Glu 
385                 390                 395                 400 


Glu Glu Glu Xaa Ala Val Arg Asp Glu Asn Cys Ala Leu Pro Ser Arg 
                405                 410                 415     


Leu His Pro Gln Val Ala His Lys Ile Gln Glu Leu Val Ser Gln Gly 
            420                 425                 430         


Ile Glu Gln Val Tyr Ala Val Arg Lys Gln Leu Arg Lys Phe Val Glu 
        435                 440                 445             


Arg Glu Leu Phe Lys Pro Asp Glu Val Pro Glu Arg His Asn Leu Ser 
    450                 455                 460                 


Phe Phe Pro Xaa Val Asn Asp Ile Lys Asn His Ile His Glu Val Gln 
465                 470                 475                 480 


Lys Ser Leu Arg Asn Gly Asp Xaa Val Tyr Asn Ser Glu Ile Ile Pro 
                485                 490                 495     


Ala Xaa Leu Gln Trp Xaa Xaa Asp Ser Gly Asn Ile Leu Lys Glu Xaa 
            500                 505                 510         


Met Xaa Val Xaa Phe Ala Glu Gly Asn Ser Pro Gly Glu Ser Ile Xaa 
        515                 520                 525             


Xaa Lys Val Glu Xaa Asn Gln Xaa Arg Gly Ser Leu Ser Pro Glu Pro 
    530                 535                 540                 


Xaa His Leu Leu Ser Ser Leu Ser Ser Phe Gln Pro Lys Ile Phe Xaa 
545                 550                 555                 560 


Gln Leu Gln Gly Leu Gln Leu Gln Pro Arg Tyr Xaa Ser Pro Asp Glu 
                565                 570                 575     


Ser Pro Ala Val Val Ser Val Asn Asn Gln Pro Ser Ser Ser Pro Ser 
            580                 585                 590         


Gly Leu Leu Asp Xaa Ile Gly Ser Ala Val Met Asn Asn Asn Ser Leu 
        595                 600                 605             


Leu Leu Gly Gln Ser His Ser Leu Gln Arg Asp Xaa Cys Leu Xaa Gln 
    610                 615                 620                 


Asn Asn Ser Xaa Ala Ser Xaa Met Gly Asn Leu Pro Glu Pro Asp Gln 
625                 630                 635                 640 


Asn Leu Val Ala Met Asp Glu Leu Val Glu Val Gly Asp Val Glu Asp 
                645                 650                 655     


Xaa Gly Asn Leu Glu Gly Xaa Val His Arg Ile Leu Leu Gly Asp Val 
            660                 665                 670         


Gln Xaa Ile Pro Ile Gln Ile Ile Asp Asn His Ser Ala Leu Ile Glu 
        675                 680                 685             


Glu Asn Pro Glu Ser Xaa Ile Ser Val Ser Gln Val Lys Gln Glu Pro 
    690                 695                 700                 


Lys Glu Pro Ala Leu Ser Met Glu Ala Lys Lys Xaa Val Asp Tyr Lys 
705                 710                 715                 720 


Lys Leu Ser Ala Xaa 
                725 


<210> 5003
<211> 80
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 5003
Met Glu Gln Ser Asn Asp Ser Leu Arg Val Asn His Asn Asp Gly Glu 
1               5                   10                  15      


Glu Ser Lys Xaa Ser Ala Gln Val Phe Glu Met Ile Val Ala Ser Pro 
            20                  25                  30          


Xaa Glu Asn Gly Gln Val Leu Arg Val Ile Pro Pro Xaa Gln Xaa Gly 
        35                  40                  45              


Met Ala Gln Val Ile Ile Pro Gln Gly Gln Leu Val Asp Val Asn Ser 
    50                  55                  60                  


Pro Arg Asp Val Pro Glu Glu Lys Pro Ser Asn Arg Asn Leu Pro Xaa 
65                  70                  75                  80  


<210> 5004
<211> 649
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<400> 5004
Met Glu Gln Ser Asn Asp Ser Leu Arg Val Asn His Asn Asp Gly Glu 
1               5                   10                  15      


Glu Ser Lys Xaa Ser Ala Gln Val Phe Glu Met Ile Val Ala Ser Pro 
            20                  25                  30          


Xaa Glu Asn Gly Gln Val Leu Arg Val Ile Pro Pro Xaa Gln Xaa Gly 
        35                  40                  45              


Met Ala Gln Val Ile Ile Pro Gln Gly Gln Leu Val Asp Val Asn Ser 
    50                  55                  60                  


Pro Arg Asp Val Pro Glu Glu Lys Pro Ser Asn Arg Asn Leu Pro Xaa 
65                  70                  75                  80  


Val Arg Val Asp Xaa Leu Ala Asp Asn Xaa Ser Asn Tyr Ile Leu His 
                85                  90                  95      


Pro Gln Xaa Ser Phe Pro Leu Pro Lys Lys Ser Val Xaa Gly Met Leu 
            100                 105                 110         


Glu Glu Pro Leu Leu Gly Pro Leu Gln Pro Leu Ser Ser Asn Xaa Pro 
        115                 120                 125             


Ile Trp Ala Cys Arg Leu Arg Ser Cys Glu Lys Ile Gly Asp Ser Tyr 
    130                 135                 140                 


Arg Gly Tyr Cys Val Ser Glu Xaa Glu Leu Glu Ser Val Leu Xaa Phe 
145                 150                 155                 160 


His Lys Gln Gln Xaa Gln Ser Val Trp Gly Xaa Arg Gln Ser Pro Ser 
                165                 170                 175     


Pro Ala Lys Pro Ala Xaa Arg Leu Met Trp Lys Ser Gln Tyr Val Pro 
            180                 185                 190         


Tyr Asp Gly Ile Pro Phe Val Asn Ala Gly Ser Arg Ala Val Val Met 
        195                 200                 205             


Glu Cys Gln Tyr Gly Pro Arg Arg Lys Gly Phe Gln Leu Lys Lys Val 
    210                 215                 220                 


Ser Glu Gln Glu Ser Arg Ser Cys Gln Leu Tyr Lys Ala Xaa Cys Pro 
225                 230                 235                 240 


Ala Arg Ile Tyr Ile Lys Lys Val Gln Lys Phe Pro Glu Tyr Arg Val 
                245                 250                 255     


Pro Xaa Asp Pro Lys Ile Asp Lys Lys Ile Ile Arg Met Glu Gln Glu 
            260                 265                 270         


Lys Ala Phe Asn Met Leu Lys Lys Asn Leu Val Asp Ala Gly Gly Val 
        275                 280                 285             


Leu Arg Trp Tyr Val Gln Leu Pro Xaa Gln Gln Ala His Gln Tyr His 
    290                 295                 300                 


Glu Leu Glu Xaa Pro Cys Leu Xaa Leu Ser Pro Ser Pro Phe Pro Val 
305                 310                 315                 320 


Ser Ser Leu Glu Glu Glu Glu Xaa Ala Val Arg Asp Glu Asn Cys Ala 
                325                 330                 335     


Leu Pro Ser Arg Leu His Pro Gln Val Ala His Lys Ile Gln Glu Leu 
            340                 345                 350         


Val Ser Gln Gly Ile Glu Gln Val Tyr Ala Val Arg Lys Gln Leu Arg 
        355                 360                 365             


Lys Phe Val Glu Arg Glu Leu Phe Lys Pro Asp Glu Val Pro Glu Arg 
    370                 375                 380                 


His Asn Leu Ser Phe Phe Pro Xaa Val Asn Asp Ile Lys Asn His Ile 
385                 390                 395                 400 


His Glu Val Gln Lys Ser Leu Arg Asn Gly Asp Xaa Val Tyr Asn Ser 
                405                 410                 415     


Glu Ile Ile Pro Ala Xaa Leu Gln Trp Xaa Xaa Asp Ser Gly Asn Ile 
            420                 425                 430         


Leu Lys Glu Xaa Met Xaa Val Xaa Phe Ala Glu Gly Asn Ser Pro Gly 
        435                 440                 445             


Glu Ser Ile Xaa Xaa Lys Val Glu Xaa Asn Gln Xaa Arg Gly Ser Leu 
    450                 455                 460                 


Ser Pro Glu Pro Xaa His Leu Leu Ser Ser Leu Ser Ser Phe Gln Pro 
465                 470                 475                 480 


Lys Ile Phe Xaa Gln Leu Gln Gly Leu Gln Leu Gln Pro Arg Tyr Xaa 
                485                 490                 495     


Ser Pro Asp Glu Ser Pro Ala Val Val Ser Val Asn Asn Gln Pro Ser 
            500                 505                 510         


Ser Ser Pro Ser Gly Leu Leu Asp Xaa Ile Gly Ser Ala Val Met Asn 
        515                 520                 525             


Asn Asn Ser Leu Leu Leu Gly Gln Ser His Ser Leu Gln Arg Asp Xaa 
    530                 535                 540                 


Cys Leu Xaa Gln Asn Asn Ser Xaa Ala Ser Xaa Met Gly Asn Leu Pro 
545                 550                 555                 560 


Glu Pro Asp Gln Asn Leu Val Ala Met Asp Glu Leu Val Glu Val Gly 
                565                 570                 575     


Asp Val Glu Asp Xaa Gly Asn Leu Glu Gly Xaa Val His Arg Ile Leu 
            580                 585                 590         


Leu Gly Asp Val Gln Xaa Ile Pro Ile Gln Ile Ile Asp Asn His Ser 
        595                 600                 605             


Ala Leu Ile Glu Glu Asn Pro Glu Ser Xaa Ile Ser Val Ser Gln Val 
    610                 615                 620                 


Lys Gln Glu Pro Lys Glu Pro Ala Leu Ser Met Glu Ala Lys Lys Xaa 
625                 630                 635                 640 


Val Asp Tyr Lys Lys Leu Ser Ala Xaa 
                645                 


<210> 5005
<211> 623
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<400> 5005
Met Ile Val Ala Ser Pro Xaa Glu Asn Gly Gln Val Leu Arg Val Ile 
1               5                   10                  15      


Pro Pro Xaa Gln Xaa Gly Met Ala Gln Val Ile Ile Pro Gln Gly Gln 
            20                  25                  30          


Leu Val Asp Val Asn Ser Pro Arg Asp Val Pro Glu Glu Lys Pro Ser 
        35                  40                  45              


Asn Arg Asn Leu Pro Xaa Val Arg Val Asp Xaa Leu Ala Asp Asn Xaa 
    50                  55                  60                  


Ser Asn Tyr Ile Leu His Pro Gln Xaa Ser Phe Pro Leu Pro Lys Lys 
65                  70                  75                  80  


Ser Val Xaa Gly Met Leu Glu Glu Pro Leu Leu Gly Pro Leu Gln Pro 
                85                  90                  95      


Leu Ser Ser Asn Xaa Pro Ile Trp Ala Cys Arg Leu Arg Ser Cys Glu 
            100                 105                 110         


Lys Ile Gly Asp Ser Tyr Arg Gly Tyr Cys Val Ser Glu Xaa Glu Leu 
        115                 120                 125             


Glu Ser Val Leu Xaa Phe His Lys Gln Gln Xaa Gln Ser Val Trp Gly 
    130                 135                 140                 


Xaa Arg Gln Ser Pro Ser Pro Ala Lys Pro Ala Xaa Arg Leu Met Trp 
145                 150                 155                 160 


Lys Ser Gln Tyr Val Pro Tyr Asp Gly Ile Pro Phe Val Asn Ala Gly 
                165                 170                 175     


Ser Arg Ala Val Val Met Glu Cys Gln Tyr Gly Pro Arg Arg Lys Gly 
            180                 185                 190         


Phe Gln Leu Lys Lys Val Ser Glu Gln Glu Ser Arg Ser Cys Gln Leu 
        195                 200                 205             


Tyr Lys Ala Xaa Cys Pro Ala Arg Ile Tyr Ile Lys Lys Val Gln Lys 
    210                 215                 220                 


Phe Pro Glu Tyr Arg Val Pro Xaa Asp Pro Lys Ile Asp Lys Lys Ile 
225                 230                 235                 240 


Ile Arg Met Glu Gln Glu Lys Ala Phe Asn Met Leu Lys Lys Asn Leu 
                245                 250                 255     


Val Asp Ala Gly Gly Val Leu Arg Trp Tyr Val Gln Leu Pro Xaa Gln 
            260                 265                 270         


Gln Ala His Gln Tyr His Glu Leu Glu Xaa Pro Cys Leu Xaa Leu Ser 
        275                 280                 285             


Pro Ser Pro Phe Pro Val Ser Ser Leu Glu Glu Glu Glu Xaa Ala Val 
    290                 295                 300                 


Arg Asp Glu Asn Cys Ala Leu Pro Ser Arg Leu His Pro Gln Val Ala 
305                 310                 315                 320 


His Lys Ile Gln Glu Leu Val Ser Gln Gly Ile Glu Gln Val Tyr Ala 
                325                 330                 335     


Val Arg Lys Gln Leu Arg Lys Phe Val Glu Arg Glu Leu Phe Lys Pro 
            340                 345                 350         


Asp Glu Val Pro Glu Arg His Asn Leu Ser Phe Phe Pro Xaa Val Asn 
        355                 360                 365             


Asp Ile Lys Asn His Ile His Glu Val Gln Lys Ser Leu Arg Asn Gly 
    370                 375                 380                 


Asp Xaa Val Tyr Asn Ser Glu Ile Ile Pro Ala Xaa Leu Gln Trp Xaa 
385                 390                 395                 400 


Xaa Asp Ser Gly Asn Ile Leu Lys Glu Xaa Met Xaa Val Xaa Phe Ala 
                405                 410                 415     


Glu Gly Asn Ser Pro Gly Glu Ser Ile Xaa Xaa Lys Val Glu Xaa Asn 
            420                 425                 430         


Gln Xaa Arg Gly Ser Leu Ser Pro Glu Pro Xaa His Leu Leu Ser Ser 
        435                 440                 445             


Leu Ser Ser Phe Gln Pro Lys Ile Phe Xaa Gln Leu Gln Gly Leu Gln 
    450                 455                 460                 


Leu Gln Pro Arg Tyr Xaa Ser Pro Asp Glu Ser Pro Ala Val Val Ser 
465                 470                 475                 480 


Val Asn Asn Gln Pro Ser Ser Ser Pro Ser Gly Leu Leu Asp Xaa Ile 
                485                 490                 495     


Gly Ser Ala Val Met Asn Asn Asn Ser Leu Leu Leu Gly Gln Ser His 
            500                 505                 510         


Ser Leu Gln Arg Asp Xaa Cys Leu Xaa Gln Asn Asn Ser Xaa Ala Ser 
        515                 520                 525             


Xaa Met Gly Asn Leu Pro Glu Pro Asp Gln Asn Leu Val Ala Met Asp 
    530                 535                 540                 


Glu Leu Val Glu Val Gly Asp Val Glu Asp Xaa Gly Asn Leu Glu Gly 
545                 550                 555                 560 


Xaa Val His Arg Ile Leu Leu Gly Asp Val Gln Xaa Ile Pro Ile Gln 
                565                 570                 575     


Ile Ile Asp Asn His Ser Ala Leu Ile Glu Glu Asn Pro Glu Ser Xaa 
            580                 585                 590         


Ile Ser Val Ser Gln Val Lys Gln Glu Pro Lys Glu Pro Ala Leu Ser 
        595                 600                 605             


Met Glu Ala Lys Lys Xaa Val Asp Tyr Lys Lys Leu Ser Ala Xaa 
    610                 615                 620             


<210> 5006
<211> 207
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<400> 5006
Met Ile Val Ala Ser Pro Xaa Glu Asn Gly Gln Val Leu Arg Val Ile 
1               5                   10                  15      


Pro Pro Xaa Gln Xaa Gly Met Ala Gln Val Ile Ile Pro Gln Gly Gln 
            20                  25                  30          


Leu Val Asp Val Asn Ser Pro Arg Asp Val Pro Glu Glu Lys Pro Ser 
        35                  40                  45              


Asn Arg Asn Leu Pro Xaa Val Arg Val Asp Xaa Leu Ala Asp Asn Xaa 
    50                  55                  60                  


Ser Asn Tyr Ile Leu His Pro Gln Xaa Ser Phe Pro Leu Pro Lys Lys 
65                  70                  75                  80  


Ser Val Xaa Gly Met Leu Glu Glu Pro Leu Leu Gly Pro Leu Gln Pro 
                85                  90                  95      


Leu Ser Ser Asn Xaa Pro Ile Trp Ala Cys Arg Leu Arg Ser Cys Glu 
            100                 105                 110         


Lys Ile Gly Asp Ser Tyr Arg Gly Tyr Cys Val Ser Glu Xaa Glu Leu 
        115                 120                 125             


Glu Ser Val Leu Xaa Phe His Lys Gln Gln Xaa Gln Ser Val Trp Gly 
    130                 135                 140                 


Xaa Arg Gln Ser Pro Ser Pro Ala Lys Pro Ala Xaa Arg Leu Met Trp 
145                 150                 155                 160 


Lys Ser Gln Tyr Val Pro Tyr Asp Gly Ile Pro Phe Val Asn Ala Gly 
                165                 170                 175     


Xaa Phe Leu Lys Asn Tyr Phe Lys Arg Phe Ser Ser Ser His Ser Pro 
            180                 185                 190         


Leu Ser Lys Cys Asp Phe Pro Lys Val Ile Xaa Phe Leu Phe Trp 
        195                 200                 205         


<210> 5007
<211> 114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<400> 5007
Met Pro Pro Pro Pro Glu Gly Gln Pro Cys His Leu Ser Leu Pro His 
1               5                   10                  15      


His His Ser Pro Pro Pro Ile Lys Leu Gln Ser Gly Cys Trp Xaa Pro 
            20                  25                  30          


Leu Gly Ala Val Ser Ala His His Pro Leu Cys Gly Ala Xaa Trp Ser 
        35                  40                  45              


Gln Ala His Cys Pro Leu Ala Gly Arg Gly Pro Ser Arg Arg Arg Cys 
    50                  55                  60                  


Gly Leu His Arg Ala Pro Ser Xaa Lys Glu Ser Ala Asn Ala Ser Ala 
65                  70                  75                  80  


Gly Pro Arg Ala Met Ala Ser Leu Leu Gln Leu Met Ala Ala Pro Xaa 
                85                  90                  95      


Ser Ser Cys Xaa Ser Leu Met Trp Lys Gly Ser Met Ser Gln Trp Lys 
            100                 105                 110         


Ala Xaa 
        


<210> 5008
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<400> 5008
Met Ser Ser Glu Pro Pro Pro Pro Pro Gln Pro Pro Xaa His Gln Ala 
1               5                   10                  15      


Ser Val Gly Leu Leu Asp Xaa Pro Arg Ser Arg Glu Arg Ser Pro Ser 
            20                  25                  30          


Pro Leu Arg Gly Asn Val Val Pro Ser Pro Leu Pro Xaa Arg Arg Xaa 
        35                  40                  45              


Arg Xaa Phe Ser Ala Xaa Val Arg Ala Ser Gln Gly Pro Val Tyr Lys 
    50                  55                  60                  


Gly Val Cys Lys Cys Phe Cys 
65                  70      


<210> 5009
<211> 112
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<400> 5009
Met Ser Ser Glu Pro Pro Pro Pro Pro Gln Pro Pro Xaa His Gln Ala 
1               5                   10                  15      


Ser Val Gly Leu Leu Asp Xaa Pro Arg Ser Arg Glu Arg Ser Pro Ser 
            20                  25                  30          


Pro Leu Arg Gly Asn Val Val Pro Ser Pro Leu Pro Xaa Arg Arg Xaa 
        35                  40                  45              


Arg Xaa Phe Ser Ala Xaa Val Arg Ala Ser Gln Gly Pro Val Tyr Lys 
    50                  55                  60                  


Gly Val Cys Lys Cys Phe Cys Arg Ser Lys Gly His Gly Phe Ile Xaa 
65                  70                  75                  80  


Pro Ala Asp Gly Gly Pro Asp Ile Phe Leu His Ile Ser Asp Val Glu 
                85                  90                  95      


Gly Glu Tyr Val Pro Val Glu Gly Asp Glu Val Xaa Tyr Lys Met Cys 
            100                 105                 110         


<210> 5010
<211> 124
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<400> 5010
Met Ser Ser Glu Pro Pro Pro Pro Pro Gln Pro Pro Xaa His Gln Ala 
1               5                   10                  15      


Ser Val Gly Leu Leu Asp Xaa Pro Arg Ser Arg Glu Arg Ser Pro Ser 
            20                  25                  30          


Pro Leu Arg Gly Asn Val Val Pro Ser Pro Leu Pro Xaa Arg Arg Xaa 
        35                  40                  45              


Arg Xaa Phe Ser Ala Xaa Val Arg Ala Ser Gln Gly Pro Val Tyr Lys 
    50                  55                  60                  


Gly Val Cys Lys Cys Phe Cys Arg Ser Lys Gly His Gly Phe Ile Xaa 
65                  70                  75                  80  


Pro Ala Asp Gly Gly Pro Asp Ile Phe Leu His Ile Ser Asp Val Glu 
                85                  90                  95      


Gly Glu Tyr Val Pro Val Glu Gly Asp Glu Val Xaa Tyr Lys Met Cys 
            100                 105                 110         


Ser Ile Pro Pro Lys Asn Glu Lys Leu Gln Ala Val 
        115                 120                 


<210> 5011
<211> 126
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<400> 5011
Met Ser Ser Glu Pro Pro Pro Pro Pro Gln Pro Pro Xaa His Gln Ala 
1               5                   10                  15      


Ser Val Gly Leu Leu Asp Xaa Pro Arg Ser Arg Glu Arg Ser Pro Ser 
            20                  25                  30          


Pro Leu Arg Gly Asn Val Val Pro Ser Pro Leu Pro Xaa Arg Arg Xaa 
        35                  40                  45              


Arg Xaa Phe Ser Ala Xaa Val Arg Ala Ser Gln Gly Pro Val Tyr Lys 
    50                  55                  60                  


Gly Val Cys Lys Cys Phe Cys Arg Ser Lys Gly His Gly Phe Ile Xaa 
65                  70                  75                  80  


Pro Ala Asp Gly Gly Pro Asp Ile Phe Leu His Ile Ser Asp Val Glu 
                85                  90                  95      


Gly Glu Tyr Val Pro Val Glu Gly Asp Glu Val Xaa Tyr Lys Met Cys 
            100                 105                 110         


Ser Ile Pro Pro Lys Asn Glu Lys Leu Gln Ala Val Glu Val 
        115                 120                 125     


<210> 5012
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 5012
Met Ser Ser Glu Pro Pro Pro Pro Pro Gln Pro Pro Xaa His Gln Ala 
1               5                   10                  15      


Ser Val Gly Leu Leu Asp Xaa Pro Arg Ser Arg Glu Arg Ser Pro Ser 
            20                  25                  30          


Pro Leu Arg Gly Asn Val Val Pro Ser Pro Leu Pro Xaa Arg Arg Xaa 
        35                  40                  45              


Arg Xaa Phe Ser Ala Xaa Val Arg Ala Ser Gln Gly Pro Val Tyr Lys 
    50                  55                  60                  


Gly Val Cys Lys Cys Phe Cys Arg Ser Lys Gly His Gly Phe Ile Xaa 
65                  70                  75                  80  


Pro Ala Asp Gly Gly Pro Asp Ile Phe Leu His Ile Ser Asp Val Glu 
                85                  90                  95      


Gly Glu Tyr Val Pro Val Glu Gly Asp Glu Val Xaa Tyr Lys Met Cys 
            100                 105                 110         


Ser Ile Pro Pro Lys Asn Glu Lys Leu Gln Ala Val Glu Val Val Ile 
        115                 120                 125             


Xaa His Leu 
    130     


<210> 5013
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<400> 5013
Met Ser Ser Glu Pro Pro Pro Pro Pro Gln Pro Pro Xaa His Gln Ala 
1               5                   10                  15      


Ser Val Gly Leu Leu Asp Xaa Pro Arg Ser Arg Glu Arg Ser Pro Ser 
            20                  25                  30          


Pro Leu Arg Gly Asn Val Val Pro Ser Pro Leu Pro Xaa Arg Arg Xaa 
        35                  40                  45              


Arg Xaa Phe Ser Ala Xaa Val Arg Ala Ser Gln Gly Pro Val Tyr Lys 
    50                  55                  60                  


Gly Val Cys Lys Cys Phe Cys Arg Ser Lys Gly His Gly Phe Ile Xaa 
65                  70                  75                  80  


Pro Ala Asp Gly Gly Pro Asp Ile Phe Leu His Ile Ser Asp Val Glu 
                85                  90                  95      


Gly Glu Tyr Val Pro Val Glu Gly Asp Glu Val Xaa Tyr Lys Met Cys 
            100                 105                 110         


Ser Ile Pro Pro Lys Asn Glu Lys Leu Gln Ala Val Glu Val Val Ile 
        115                 120                 125             


Xaa His Leu Ala Pro Gly Xaa Lys His Glu Xaa Trp Ser Gly His Val 
    130                 135                 140                 


Ile Ser Ser 
145         


<210> 5014
<211> 94
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 5014
Met Ser Ser Glu Pro Pro Pro Pro Pro Gln Pro Pro Xaa His Gln Ala 
1               5                   10                  15      


Ser Val Gly Leu Leu Asp Xaa Pro Arg Ser Arg Glu Arg Ser Pro Ser 
            20                  25                  30          


Pro Leu Arg Gly Asn Val Val Pro Ser Pro Leu Pro Xaa Arg Arg Xaa 
        35                  40                  45              


Arg Xaa Phe Ser Ala Xaa Val Arg Ala Ser Gln Gly Pro Val Tyr Lys 
    50                  55                  60                  


Gly Val Cys Lys Cys Phe Cys Arg Ser Lys Gly His Gly Phe Ile Xaa 
65                  70                  75                  80  


Pro Ala Asp Gly Gly Pro Asp Ile Phe Leu His Ile Ser Glu 
                85                  90                  


<210> 5015
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<400> 5015
Ala Glu Gln Gln Ala Leu Arg Leu Glu Val Arg Ala Gly Pro Asp Ser 
1               5                   10                  15      


Ala Gly Ile Ala Leu Tyr Ser His Glu Asp Val Cys Val Phe Lys Cys 
            20                  25                  30          


Ser Val Ser Arg Glu Xaa Glu Cys Ser Arg Val Gly Lys Gln Ser Phe 
        35                  40                  45              


Ile Ile Xaa Leu Gly Cys Asn Ser Val Leu Ile Gln Phe Ala Xaa Pro 
    50                  55                  60                  


Asn Asp Phe Cys Ser Phe Tyr Asn Ile Leu Lys Xaa Cys Arg Gly His 
65                  70                  75                  80  


Xaa Leu Glu Arg Ser Val Phe Ser Glu Arg Xaa Glu Glu Ser Ser Ala 
                85                  90                  95      


Val Gln Tyr Phe Gln Met Arg Lys Leu Arg Leu Arg Glu Val Lys 
            100                 105                 110     


<210> 5016
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<400> 5016
Ala Leu Tyr Ser His Glu Asp Val Cys Val Phe Lys Cys Ser Val Ser 
1               5                   10                  15      


Arg Glu Xaa Glu Cys Ser Arg Val Gly Lys Gln Ser Phe Ile Ile Xaa 
            20                  25                  30          


Leu Gly Cys Asn Ser Val Leu Ile Gln Phe Ala Xaa Pro Asn Asp Phe 
        35                  40                  45              


Cys Ser Phe Tyr Asn Ile Leu Lys Xaa Cys Arg Gly His Xaa Leu Glu 
    50                  55                  60                  


Arg Ser Val Phe Ser Glu Arg Xaa Glu Glu Ser Ser Ala Val Gln Tyr 
65                  70                  75                  80  


Phe Gln Met Arg Lys Leu Arg Leu Arg Glu Val Lys 
                85                  90          


<210> 5017
<211> 176
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<400> 5017
Leu Ala Phe Trp Phe Asp Val Ala Phe Ile Gly Ser Ile Gln Ser Tyr 
1               5                   10                  15      


Asp Ile Ser Ile Val Ala Gln Val Asp Gln Xaa Gly Ser Lys Ser Ser 
            20                  25                  30          


Asn Leu Leu Asp Leu Lys Asn Pro Phe Phe Arg Tyr Xaa Gly Xaa Xaa 
        35                  40                  45              


Pro Ser Pro Pro Pro Gly Ser His Tyr Xaa Ser Pro Ser Glu Asn Met 
    50                  55                  60                  


Trp Asn Xaa Gly Ser Xaa Tyr Asn Leu Ser Ser Gly Met Ala Val Ala 
65                  70                  75                  80  


Gly Met Pro Xaa Ala Tyr Asp Leu Ser Ser Val Ile Ala Ser Gly Ser 
                85                  90                  95      


Ser Val Gly His Asn Asn Leu Ile Pro Leu Ala Asn Xaa Gly Ile Val 
            100                 105                 110         


Asn His Xaa His Ser Arg Met Gly Ser Ile Met Ser Xaa Gly Ile Val 
        115                 120                 125             


Gln Gly Ser Ser Gly Ala Gln Gly Ser Gly Gly Gly Ser Xaa Ser Ala 
    130                 135                 140                 


His Tyr Ala Val Asn Ser Gln Phe Xaa Met Gly Gly Pro Ala Ile Ser 
145                 150                 155                 160 


Met Ala Ser Pro Met Ser Ile Pro Xaa Asn Xaa Met His Tyr Gly Ser 
                165                 170                 175     


<210> 5018
<211> 585
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<400> 5018
Met Ala Ala Ala Ala Ala Ala Val Gly Pro Gly Ala Gly Gly Ala Gly 
1               5                   10                  15      


Ser Ala Val Pro Gly Gly Ala Gly Pro Cys Ala Xaa Val Ser Val Phe 
            20                  25                  30          


Pro Gly Ala Arg Leu Leu Xaa Ile Gly Asp Ala Asn Gly Glu Ile Gln 
        35                  40                  45              


Arg His Ala Glu Gln Gln Ala Leu Arg Leu Glu Val Arg Ala Gly Pro 
    50                  55                  60                  


Asp Ser Ala Gly Ile Ala Leu Tyr Ser His Glu Asp Val Cys Val Phe 
65                  70                  75                  80  


Lys Cys Ser Val Ser Arg Glu Xaa Glu Cys Ser Arg Val Gly Lys Gln 
                85                  90                  95      


Ser Phe Ile Ile Xaa Leu Gly Cys Asn Ser Val Leu Ile Gln Phe Ala 
            100                 105                 110         


Xaa Pro Asn Asp Phe Cys Ser Phe Tyr Asn Ile Leu Lys Xaa Cys Arg 
        115                 120                 125             


Gly His Xaa Leu Glu Arg Ser Val Phe Ser Glu Arg Xaa Glu Glu Ser 
    130                 135                 140                 


Ser Ala Val Gln Tyr Phe Gln Phe Tyr Gly Tyr Leu Ser Gln Gln Gln 
145                 150                 155                 160 


Asn Met Met Gln Asp Tyr Val Arg Xaa Gly Xaa Tyr Gln Arg Ala Ile 
                165                 170                 175     


Leu Gln Asn His Xaa Asp Phe Lys Asp Lys Ile Val Leu Asp Val Gly 
            180                 185                 190         


Cys Gly Ser Gly Ile Leu Ser Phe Phe Ala Ala Gln Ala Gly Ala Arg 
        195                 200                 205             


Lys Ile Tyr Ala Val Glu Ala Ser Xaa Met Ala Gln His Ala Glu Val 
    210                 215                 220                 


Leu Val Lys Ser Asn Asn Leu Xaa Asp Arg Ile Val Val Ile Pro Gly 
225                 230                 235                 240 


Lys Val Glu Glu Val Ser Leu Pro Glu Gln Val Asp Ile Ile Ile Ser 
                245                 250                 255     


Glu Pro Met Gly Tyr Met Leu Phe Asn Glu Arg Met Leu Glu Ser Tyr 
            260                 265                 270         


Leu His Ala Lys Lys Tyr Leu Lys Pro Ser Gly Asn Met Phe Pro Xaa 
        275                 280                 285             


Ile Gly Asp Val His Leu Ala Pro Phe Xaa Asp Glu Gln Leu Tyr Met 
    290                 295                 300                 


Glu Gln Phe Xaa Lys Ala Asn Phe Trp Tyr Gln Pro Ser Phe His Gly 
305                 310                 315                 320 


Val Asp Leu Ser Ala Leu Arg Gly Ala Ala Val Asp Glu Tyr Phe Arg 
                325                 330                 335     


Gln Pro Val Val Asp Xaa Phe Asp Ile Arg Ile Leu Met Ala Lys Ser 
            340                 345                 350         


Val Lys Tyr Xaa Val Asn Phe Leu Glu Ala Lys Glu Gly Asp Leu His 
        355                 360                 365             


Arg Ile Glu Ile Pro Phe Lys Phe His Met Leu His Ser Gly Leu Val 
    370                 375                 380                 


His Gly Leu Ala Phe Trp Phe Asp Val Ala Phe Ile Gly Ser Ile Met 
385                 390                 395                 400 


Xaa Val Trp Leu Ser Xaa Ala Pro Xaa Glu Pro Leu Xaa His Trp Tyr 
                405                 410                 415     


Gln Val Arg Cys Leu Phe Gln Ser Pro Leu Phe Ala Lys Ala Gly Asp 
            420                 425                 430         


Xaa Leu Ser Gly Xaa Cys Leu Leu Ile Ala Asn Lys Arg Gln Ser Tyr 
        435                 440                 445             


Asp Ile Ser Ile Val Ala Gln Val Asp Gln Xaa Gly Ser Lys Ser Ser 
    450                 455                 460                 


Asn Leu Leu Asp Leu Lys Asn Pro Phe Phe Arg Tyr Xaa Gly Xaa Xaa 
465                 470                 475                 480 


Pro Ser Pro Pro Pro Gly Ser His Tyr Xaa Ser Pro Ser Glu Asn Met 
                485                 490                 495     


Trp Asn Xaa Gly Ser Xaa Tyr Asn Leu Ser Ser Gly Met Ala Val Ala 
            500                 505                 510         


Gly Met Pro Xaa Ala Tyr Asp Leu Ser Ser Val Ile Ala Ser Gly Ser 
        515                 520                 525             


Ser Val Gly His Asn Asn Leu Ile Pro Leu Gly Ser Ser Gly Ala Gln 
    530                 535                 540                 


Gly Ser Gly Gly Gly Ser Xaa Ser Ala His Tyr Ala Val Asn Ser Gln 
545                 550                 555                 560 


Phe Xaa Met Gly Gly Pro Ala Ile Ser Met Ala Ser Pro Met Ser Ile 
                565                 570                 575     


Pro Xaa Asn Xaa Met His Tyr Gly Ser 
            580                 585 


<210> 5019
<211> 608
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<400> 5019
Met Ala Ala Ala Ala Ala Ala Val Gly Pro Gly Ala Gly Gly Ala Gly 
1               5                   10                  15      


Ser Ala Val Pro Gly Gly Ala Gly Pro Cys Ala Xaa Val Ser Val Phe 
            20                  25                  30          


Pro Gly Ala Arg Leu Leu Xaa Ile Gly Asp Ala Asn Gly Glu Ile Gln 
        35                  40                  45              


Arg His Ala Glu Gln Gln Ala Leu Arg Leu Glu Val Arg Ala Gly Pro 
    50                  55                  60                  


Asp Ser Ala Gly Ile Ala Leu Tyr Ser His Glu Asp Val Cys Val Phe 
65                  70                  75                  80  


Lys Cys Ser Val Ser Arg Glu Xaa Glu Cys Ser Arg Val Gly Lys Gln 
                85                  90                  95      


Ser Phe Ile Ile Xaa Leu Gly Cys Asn Ser Val Leu Ile Gln Phe Ala 
            100                 105                 110         


Xaa Pro Asn Asp Phe Cys Ser Phe Tyr Asn Ile Leu Lys Xaa Cys Arg 
        115                 120                 125             


Gly His Xaa Leu Glu Arg Ser Val Phe Ser Glu Arg Xaa Glu Glu Ser 
    130                 135                 140                 


Ser Ala Val Gln Tyr Phe Gln Phe Tyr Gly Tyr Leu Ser Gln Gln Gln 
145                 150                 155                 160 


Asn Met Met Gln Asp Tyr Val Arg Xaa Gly Xaa Tyr Gln Arg Ala Ile 
                165                 170                 175     


Leu Gln Asn His Xaa Asp Phe Lys Asp Lys Ile Val Leu Asp Val Gly 
            180                 185                 190         


Cys Gly Ser Gly Ile Leu Ser Phe Phe Ala Ala Gln Ala Gly Ala Arg 
        195                 200                 205             


Lys Ile Tyr Ala Val Glu Ala Ser Xaa Met Ala Gln His Ala Glu Val 
    210                 215                 220                 


Leu Val Lys Ser Asn Asn Leu Xaa Asp Arg Ile Val Val Ile Pro Gly 
225                 230                 235                 240 


Lys Val Glu Glu Val Ser Leu Pro Glu Gln Val Asp Ile Ile Ile Ser 
                245                 250                 255     


Glu Pro Met Gly Tyr Met Leu Phe Asn Glu Arg Met Leu Glu Ser Tyr 
            260                 265                 270         


Leu His Ala Lys Lys Tyr Leu Lys Pro Ser Gly Asn Met Phe Pro Xaa 
        275                 280                 285             


Ile Gly Asp Val His Leu Ala Pro Phe Xaa Asp Glu Gln Leu Tyr Met 
    290                 295                 300                 


Glu Gln Phe Xaa Lys Ala Asn Phe Trp Tyr Gln Pro Ser Phe His Gly 
305                 310                 315                 320 


Val Asp Leu Ser Ala Leu Arg Gly Ala Ala Val Asp Glu Tyr Phe Arg 
                325                 330                 335     


Gln Pro Val Val Asp Xaa Phe Asp Ile Arg Ile Leu Met Ala Lys Ser 
            340                 345                 350         


Val Lys Tyr Xaa Val Asn Phe Leu Glu Ala Lys Glu Gly Asp Leu His 
        355                 360                 365             


Arg Ile Glu Ile Pro Phe Lys Phe His Met Leu His Ser Gly Leu Val 
    370                 375                 380                 


His Gly Leu Ala Phe Trp Phe Asp Val Ala Phe Ile Gly Ser Ile Met 
385                 390                 395                 400 


Xaa Val Trp Leu Ser Xaa Ala Pro Xaa Glu Pro Leu Xaa His Trp Tyr 
                405                 410                 415     


Gln Val Arg Cys Leu Phe Gln Ser Pro Leu Phe Ala Lys Ala Gly Asp 
            420                 425                 430         


Xaa Leu Ser Gly Xaa Cys Leu Leu Ile Ala Asn Lys Arg Gln Ser Tyr 
        435                 440                 445             


Asp Ile Ser Ile Val Ala Gln Val Asp Gln Xaa Gly Ser Lys Ser Ser 
    450                 455                 460                 


Asn Leu Leu Asp Leu Lys Asn Pro Phe Phe Arg Tyr Xaa Gly Xaa Xaa 
465                 470                 475                 480 


Pro Ser Pro Pro Pro Gly Ser His Tyr Xaa Ser Pro Ser Glu Asn Met 
                485                 490                 495     


Trp Asn Xaa Gly Ser Xaa Tyr Asn Leu Ser Ser Gly Met Ala Val Ala 
            500                 505                 510         


Gly Met Pro Xaa Ala Tyr Asp Leu Ser Ser Val Ile Ala Ser Gly Ser 
        515                 520                 525             


Ser Val Gly His Asn Asn Leu Ile Pro Leu Ala Asn Xaa Gly Ile Val 
    530                 535                 540                 


Asn His Xaa His Ser Arg Met Gly Ser Ile Met Ser Xaa Gly Ile Val 
545                 550                 555                 560 


Gln Gly Ser Ser Gly Ala Gln Gly Ser Gly Gly Gly Ser Xaa Ser Ala 
                565                 570                 575     


His Tyr Ala Val Asn Ser Gln Phe Xaa Met Gly Gly Pro Ala Ile Ser 
            580                 585                 590         


Met Ala Ser Pro Met Ser Ile Pro Xaa Asn Xaa Met His Tyr Gly Ser 
        595                 600                 605             


<210> 5020
<211> 161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<400> 5020
Met Ala Ala Ala Ala Ala Ala Val Gly Pro Gly Ala Gly Gly Ala Gly 
1               5                   10                  15      


Ser Ala Val Pro Gly Gly Ala Gly Pro Cys Ala Xaa Val Ser Val Phe 
            20                  25                  30          


Pro Gly Ala Arg Leu Leu Xaa Ile Gly Asp Ala Asn Gly Glu Ile Gln 
        35                  40                  45              


Arg His Ala Glu Gln Gln Ala Leu Arg Leu Glu Val Arg Ala Gly Pro 
    50                  55                  60                  


Asp Ser Ala Gly Ile Ala Leu Tyr Ser His Glu Asp Val Cys Val Phe 
65                  70                  75                  80  


Lys Cys Ser Val Ser Arg Glu Xaa Glu Cys Ser Arg Val Gly Lys Gln 
                85                  90                  95      


Ser Phe Ile Ile Xaa Leu Gly Cys Asn Ser Val Leu Ile Gln Phe Ala 
            100                 105                 110         


Xaa Pro Asn Asp Phe Cys Ser Phe Tyr Asn Ile Leu Lys Xaa Cys Arg 
        115                 120                 125             


Gly His Xaa Leu Glu Arg Ser Val Phe Ser Glu Arg Xaa Glu Glu Ser 
    130                 135                 140                 


Ser Ala Val Gln Tyr Phe Gln Met Arg Lys Leu Arg Leu Arg Glu Val 
145                 150                 155                 160 


Lys 
    


<210> 5021
<211> 120
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<400> 5021
Met Ala Ala Ala Ala Ala Ala Val Gly Pro Gly Ala Gly Gly Ala Gly 
1               5                   10                  15      


Ser Ala Val Pro Gly Gly Ala Gly Pro Cys Ala Xaa Val Ser Val Phe 
            20                  25                  30          


Pro Gly Ala Arg Leu Leu Xaa Ile Gly Asp Ala Asn Gly Glu Ile Gln 
        35                  40                  45              


Arg His Ala Glu Gln Gln Ala Leu Arg Leu Glu Val Arg Ala Gly Pro 
    50                  55                  60                  


Asp Ser Ala Gly Ile Ala Leu Tyr Ser His Phe Cys Ser Phe Tyr Asn 
65                  70                  75                  80  


Ile Leu Lys Xaa Cys Arg Gly His Xaa Leu Glu Arg Ser Val Phe Ser 
                85                  90                  95      


Glu Arg Xaa Glu Glu Ser Ser Ala Val Gln Tyr Phe Gln Phe Tyr Gly 
            100                 105                 110         


Tyr Leu Ser Gln Gln Gln Asn Met 
        115                 120 


<210> 5022
<211> 343
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<400> 5022
Xaa Ala Asn Gly Glu Ile Gln Arg His Ala Glu Gln Gln Ala Leu Arg 
1               5                   10                  15      


Leu Glu Val Arg Ala Gly Pro Asp Ser Ala Gly Ile Ala Leu Tyr Ser 
            20                  25                  30          


His Glu Asp Val Cys Val Phe Lys Cys Ser Val Ser Arg Glu Xaa Glu 
        35                  40                  45              


Cys Ser Arg Val Gly Lys Gln Ser Phe Ile Ile Xaa Leu Gly Cys Asn 
    50                  55                  60                  


Ser Val Leu Ile Gln Phe Ala Xaa Pro Asn Asp Phe Cys Ser Phe Tyr 
65                  70                  75                  80  


Asn Ile Leu Lys Xaa Cys Arg Gly His Xaa Leu Glu Arg Ser Val Phe 
                85                  90                  95      


Ser Glu Arg Xaa Glu Glu Ser Ser Ala Val Gln Tyr Phe Gln Phe Tyr 
            100                 105                 110         


Gly Tyr Leu Ser Gln Gln Gln Asn Met Met Gln Asp Tyr Val Arg Xaa 
        115                 120                 125             


Gly Xaa Tyr Gln Arg Ala Ile Leu Gln Asn His Xaa Asp Phe Lys Asp 
    130                 135                 140                 


Lys Ile Val Leu Asp Val Gly Cys Gly Ser Gly Ile Leu Ser Phe Phe 
145                 150                 155                 160 


Ala Ala Gln Ala Gly Ala Arg Lys Ile Tyr Ala Val Glu Ala Ser Xaa 
                165                 170                 175     


Met Ala Gln His Ala Glu Val Leu Val Lys Ser Asn Asn Leu Xaa Asp 
            180                 185                 190         


Arg Ile Val Val Ile Pro Gly Lys Val Glu Glu Val Ser Leu Pro Glu 
        195                 200                 205             


Gln Val Asp Ile Ile Ile Ser Glu Pro Met Gly Tyr Met Leu Phe Asn 
    210                 215                 220                 


Glu Arg Met Leu Glu Ser Tyr Leu His Ala Lys Lys Tyr Leu Lys Pro 
225                 230                 235                 240 


Ser Gly Asn Met Phe Pro Xaa Ile Gly Asp Val His Leu Ala Pro Phe 
                245                 250                 255     


Xaa Asp Glu Gln Leu Tyr Met Glu Gln Phe Xaa Lys Ala Asn Phe Trp 
            260                 265                 270         


Tyr Gln Pro Ser Phe His Gly Val Asp Leu Ser Ala Leu Arg Gly Ala 
        275                 280                 285             


Ala Val Asp Glu Tyr Phe Arg Gln Pro Val Val Asp Xaa Phe Asp Ile 
    290                 295                 300                 


Arg Ile Leu Met Ala Lys Ser Val Lys Tyr Xaa Val Asn Phe Leu Glu 
305                 310                 315                 320 


Ala Lys Glu Gly Asp Leu His Ser Ala Cys Leu Ala Ser Pro Ala Ala 
                325                 330                 335     


Xaa Ala Leu Cys Leu Pro Gly 
            340             


<210> 5023
<211> 116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<400> 5023
Met Glu Ser Ser Arg Val Arg Leu Leu Pro Leu Leu Gly Ala Ala Leu 
1               5                   10                  15      


Leu Leu Met Leu Pro Leu Leu Gly Xaa Arg Ala Gln Glu Asp Ala Glu 
            20                  25                  30          


Leu Gln Pro Arg Ala Leu Asp Ile Tyr Ser Ala Val Asp Asp Ala Ser 
        35                  40                  45              


His Glu Lys Glu Leu Ile Glu Ala Leu Gln Glu Val Leu Lys Lys Leu 
    50                  55                  60                  


Lys Ser Lys Arg Val Pro Ile Tyr Glu Lys Lys Tyr Gly Gln Val Pro 
65                  70                  75                  80  


Met Cys Asp Ala Gly Glu Gln Cys Ala Val Arg Lys Gly Ala Arg Ile 
                85                  90                  95      


Gly Lys Leu Cys Asp Cys Pro Arg Gly Xaa Ser Cys Asn Ser Phe Leu 
            100                 105                 110         


Leu Lys Cys Leu 
        115     


<210> 5024
<211> 1431
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1071)..(1071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1123)..(1123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1176)..(1176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1244)..(1244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1246)..(1246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1317)..(1317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<400> 5024
Met Gly Lys Glu Gln Glu Leu Val Gln Ala Val Lys Ala Glu Asp Val 
1               5                   10                  15      


Gly Xaa Ala Gln Arg Leu Leu Gln Arg Pro Arg Pro Gly Lys Ala Lys 
            20                  25                  30          


Leu Leu Gly Ser Xaa Lys Lys Ile Asn Val Asn Phe Gln Asp Pro Asp 
        35                  40                  45              


Gly Phe Ser Ala Leu His His Ala Ala Leu Asn Gly Asn Xaa Glu Leu 
    50                  55                  60                  


Ile Ser Leu Leu Leu Glu Ala Gln Ala Ala Val Asp Ile Lys Asp Asn 
65                  70                  75                  80  


Lys Gly Met Arg Pro Leu His Tyr Ala Ala Trp Gln Gly Arg Lys Glu 
                85                  90                  95      


Pro Met Lys Leu Val Leu Lys Ala Gly Ser Ala Val Asn Ile Pro Ser 
            100                 105                 110         


Asp Glu Gly His Ile Pro Leu His Leu Ala Ala Gln His Gly His Tyr 
        115                 120                 125             


Asp Val Ser Glu Met Leu Leu Gln His Gln Ser Asn Pro Cys Met Val 
    130                 135                 140                 


Asp Asn Ser Gly Lys Xaa Pro Leu Asp Leu Ala Cys Glu Phe Gly Arg 
145                 150                 155                 160 


Val Gly Val Val Gln Leu Leu Leu Ser Ser Asn Met Cys Ala Ala Leu 
                165                 170                 175     


Leu Glu Pro Arg Pro Gly Asp Ala Xaa Asp Pro Asn Gly Xaa Ser Pro 
            180                 185                 190         


Leu His Leu Ala Ala Lys Asn Gly His Ile Asp Ile Ile Arg Leu Leu 
        195                 200                 205             


Leu Gln Ala Gly Ile Asp Ile Asn Arg Gln Xaa Lys Ser Gly Xaa Ala 
    210                 215                 220                 


Leu His Glu Ala Ala Leu Cys Gly Lys Xaa Glu Val Val Arg Leu Leu 
225                 230                 235                 240 


Leu Asp Ser Gly Ile Asn Ala His Val Arg Asn Xaa Tyr Ser Gln Xaa 
                245                 250                 255     


Ala Leu Asp Ile Val His Gln Phe Xaa Xaa Ser Gln Ala Ser Arg Glu 
            260                 265                 270         


Ile Lys Gln Leu Leu Arg Glu Ala Ser Ala Ala Leu Gln Val Arg Ala 
        275                 280                 285             


Xaa Lys Asp Tyr Cys Asn Asn Tyr Asp Leu Xaa Ser Leu Asn Val Lys 
    290                 295                 300                 


Ala Gly Asp Ile Ile Xaa Val Leu Glu Gln His Pro Asp Gly Arg Trp 
305                 310                 315                 320 


Lys Gly Cys Ile His Asp Asn Arg Xaa Gly Asn Asp Arg Val Gly Tyr 
                325                 330                 335     


Phe Pro Ser Ser Leu Gly Glu Ala Ile Val Lys Arg Ala Gly Ser Arg 
            340                 345                 350         


Ala Gly Xaa Glu Pro Ser Leu Pro Gln Gly Ser Ser Ser Ser Gly Pro 
        355                 360                 365             


Ser Ala Pro Pro Glu Glu Ile Trp Val Leu Arg Lys Pro Phe Ala Gly 
    370                 375                 380                 


Gly Asp Arg Ser Gly Ser Ile Ser Gly Met Ala Gly Gly Arg Gly Ser 
385                 390                 395                 400 


Gly Gly His Ala Leu His Ala Gly Ser Glu Gly Val Lys Leu Leu Ala 
                405                 410                 415     


Xaa Val Leu Ser Gln Lys Ser Val Ser Glu Ser Gly Pro Gly Asp Ser 
            420                 425                 430         


Pro Ala Lys Pro Pro Glu Gly Ser Ala Gly Val Ala Arg Ser Gln Pro 
        435                 440                 445             


Pro Val Ala His Ala Gly Gln Val Tyr Gly Glu Gln Pro Pro Lys Lys 
    450                 455                 460                 


Leu Glu Pro Ala Ser Glu Gly Lys Ser Ser Glu Ala Val Ser Gln Trp 
465                 470                 475                 480 


Leu Xaa Ala Phe Gln Leu Gln Leu Tyr Ala Pro Asn Phe Ile Ser Ala 
                485                 490                 495     


Gly Tyr Asp Leu Pro Xaa Ile Ser Arg Met Xaa Pro Glu Asp Leu Xaa 
            500                 505                 510         


Ala Ile Gly Val Xaa Lys Pro Gly His Arg Lys Lys Ile Ala Ala Glu 
        515                 520                 525             


Ile Ser Gly Leu Ser Ile Pro Asp Trp Leu Pro Glu His Lys Pro Ala 
    530                 535                 540                 


Asn Leu Ala Val Trp Leu Ser Met Ile Gly Leu Ala Gln Tyr Tyr Lys 
545                 550                 555                 560 


Val Leu Val Asp Asn Gly Tyr Glu Asn Ile Asp Phe Ile Xaa Asp Ile 
                565                 570                 575     


Xaa Trp Glu Asp Leu Gln Glu Ile Gly Ile Xaa Lys Leu Gly His Gln 
            580                 585                 590         


Lys Lys Leu Met Leu Ala Val Arg Lys Leu Ala Glu Leu Gln Lys Ala 
        595                 600                 605             


Glu Tyr Ala Lys Tyr Glu Gly Gly Pro Leu Arg Arg Lys Ala Pro Gln 
    610                 615                 620                 


Ser Leu Glu Val Met Ala Ile Glu Ser Pro Pro Pro Pro Glu Pro Xaa 
625                 630                 635                 640 


Pro Ala Asp Cys Gln Ser Pro Lys Met Xaa Xaa Phe Gln Asp Ser Glu 
                645                 650                 655     


Leu Ser Asp Glu Leu Gln Ala Ala Met Xaa Gly Pro Ala Glu Val Gly 
            660                 665                 670         


Pro Xaa Xaa Glu Lys Pro Ser Ser His Leu Pro Pro Xaa Pro Arg Ala 
        675                 680                 685             


Xaa Xaa Arg Gln Asp Ser Ser Leu Gly Gly Arg Ala Arg His Met Ser 
    690                 695                 700                 


Ser Ser Gln Glu Leu Leu Gly Asp Gly Pro Pro Gly Pro Ser Ser Pro 
705                 710                 715                 720 


Met Ser Arg Ser Gln Glu Tyr Leu Leu Asp Glu Gly Pro Ala Pro Gly 
                725                 730                 735     


Xaa Pro Pro Arg Glu Ala Arg Pro Gly Arg His Gly His Ser Ile Lys 
            740                 745                 750         


Arg Ala Ser Val Pro Pro Val Pro Gly Lys Pro Arg Gln Val Leu Pro 
        755                 760                 765             


Pro Gly Xaa Ser His Phe Xaa Pro Pro Gln Xaa Pro Xaa Lys Xaa Arg 
    770                 775                 780                 


Pro Gly Ser Pro Gln Ala Leu Gly Gly Pro His Gly Pro Ala Pro Ala 
785                 790                 795                 800 


Xaa Ala Lys Val Lys Pro Xaa Pro Gln Leu Leu Pro Pro Xaa Glu Arg 
                805                 810                 815     


Pro Met Ser Pro Arg Ser Leu Pro Gln Ser Pro Xaa His Arg Gly Phe 
            820                 825                 830         


Ala Tyr Val Leu Pro Gln Pro Val Glu Gly Glu Val Gly Pro Ala Ala 
        835                 840                 845             


Pro Gly Pro Ala Pro Pro Pro Val Pro Xaa Ala Val Pro Xaa Leu Cys 
    850                 855                 860                 


Leu Pro Pro Glu Ala Asp Ala Glu Pro Gly Arg Pro Lys Lys Arg Ala 
865                 870                 875                 880 


His Ser Leu Asn Arg Tyr Ala Ala Ser Asp Ser Glu Pro Glu Arg Asp 
                885                 890                 895     


Glu Leu Leu Val Pro Ala Ala Ala Gly Pro Tyr Ala Xaa Val Gln Arg 
            900                 905                 910         


Arg Val Gly Arg Ser His Ser Val Arg Ala Pro Ala Gly Ala Asp Lys 
        915                 920                 925             


Asn Val Asn Arg Ser Gln Ser Phe Ala Val Arg Pro Arg Lys Lys Gly 
    930                 935                 940                 


Pro Pro Pro Pro Pro Pro Lys Arg Ser Ser Ser Ala Leu Ala Ser Ala 
945                 950                 955                 960 


Asn Leu Ala Asp Glu Pro Val Pro Asp Ala Glu Pro Glu Asp Gly Leu 
                965                 970                 975     


Leu Gly Val Arg Ala Gln Cys Arg Arg Ala Ser Asp Leu Ala Gly Ser 
            980                 985                 990         


Val Asp Xaa Gly Ser Ala Gly Ser  Val Lys Ser Ile Ala  Ala Met Leu 
        995                 1000                 1005             


Glu Leu  Ser Ser Ile Gly Gly  Gly Gly Arg Ala Ala  Arg Arg Pro 
    1010                 1015                 1020             


Pro Glu  Gly His Pro Xaa Pro  Arg Pro Ala Ser Pro  Glu Pro Gly 
    1025                 1030                 1035             


Arg Val  Ala Xaa Val Leu Ala  Ser Val Lys His Lys  Glu Ala Ile 
    1040                 1045                 1050             


Gly Pro  Gly Gly Glu Val Val  Asn Arg Arg Arg Xaa  Leu Ser Gly 
    1055                 1060                 1065             


Pro Val  Xaa Gly Leu Leu Ala  Xaa Ala Arg Arg Gly  Pro Gly Glu 
    1070                 1075                 1080             


Ser Ala  Asp Pro Gly Pro Phe  Val Glu Asp Gly Xaa  Gly Arg Gln 
    1085                 1090                 1095             


Arg Pro  Arg Gly Pro Ser Lys  Gly Glu Ala Gly Val  Glu Gly Pro 
    1100                 1105                 1110             


Pro Leu  Ala Lys Val Glu Ala  Ser Ala Xaa Leu Lys  Arg Arg Ile 
    1115                 1120                 1125             


Arg Ala  Lys Gln Asn Gln Gln  Glu Asn Val Lys Phe  Ile Leu Xaa 
    1130                 1135                 1140             


Glu Ser  Asp Xaa Val Lys Arg  Arg Pro Lys Ala Lys  Glu Arg Glu 
    1145                 1150                 1155             


Ala Gly  Pro Glu Pro Pro Pro  Pro Leu Ser Val Tyr  His Asn Gly 
    1160                 1165                 1170             


Xaa Gly  Xaa Val Arg Arg Arg  Pro Ala Ser Glu Gln  Ala Gly Pro 
    1175                 1180                 1185             


Pro Glu  Leu Pro Pro Pro Pro  Pro Pro Ala Glu Pro  Pro Pro Xaa 
    1190                 1195                 1200             


Asp Leu  Ala His Leu Pro Pro  Leu Pro Pro Pro Glu  Gly Glu Ala 
    1205                 1210                 1215             


Arg Lys  Pro Ala Lys Pro Pro  Val Ser Pro Lys Pro  Val Leu Xaa 
    1220                 1225                 1230             


Gln Pro  Val Pro Lys Leu Gln  Gly Ser Pro Xaa Pro  Xaa Ser Lys 
    1235                 1240                 1245             


Lys Val  Pro Leu Pro Gly Pro  Gly Ser Pro Glu Val  Lys Arg Ala 
    1250                 1255                 1260             


His Gly  Xaa Pro Pro Pro Val  Ser Pro Lys Pro Pro  Pro Pro Pro 
    1265                 1270                 1275             


Xaa Ala  Pro Lys Pro Val Lys  Ala Val Ala Gly Leu  Pro Ser Gly 
    1280                 1285                 1290             


Ser Ala  Gly Pro Ser Pro Ala  Pro Ser Pro Ala Arg  Gln Pro Pro 
    1295                 1300                 1305             


Ala Ala  Leu Ala Lys Pro Pro  Gly Xaa Pro Pro Ser  Leu Gly Ala 
    1310                 1315                 1320             


Ser Pro  Ala Lys Pro Pro Ser  Pro Gly Ala Pro Ala  Leu His Val 
    1325                 1330                 1335             


Pro Ala  Lys Pro Pro Arg Ala  Ala Ala Ala Ala Ala  Ala Ala Ala 
    1340                 1345                 1350             


Ala Ala  Pro Pro Ala Pro Pro  Glu Gly Ala Ser Pro  Gly Asp Ser 
    1355                 1360                 1365             


Ala Arg  Gln Lys Leu Glu Glu  Xaa Ser Ala Cys Leu  Ala Ala Ala 
    1370                 1375                 1380             


Leu Gln  Ala Val Glu Glu Lys  Ile Arg Gln Glu Asp  Ala Gln Gly 
    1385                 1390                 1395             


Pro Arg  Asp Ser Ala Ala Glu  Lys Ser Xaa Gly Ser  Ile Leu Asp 
    1400                 1405                 1410             


Asp Ile  Gly Ser Met Phe Asp  Asp Leu Ala Asp Gln  Leu Asp Ala 
    1415                 1420                 1425             


Met Leu  Glu 
    1430     


<210> 5025
<211> 26
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<400> 5025
Met Gly Arg Glu Gln Asp Leu Ile Leu Ala Val Lys Asn Gly Asp Val 
1               5                   10                  15      


Xaa Gly Val Gln Lys Leu Val Ala Lys Val 
            20                  25      


<210> 5026
<211> 323
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<400> 5026
Met Gly Arg Glu Gln Asp Leu Ile Leu Ala Val Lys Asn Gly Asp Val 
1               5                   10                  15      


Xaa Gly Val Gln Lys Leu Val Ala Lys Val Lys Ala Xaa Lys Xaa Lys 
            20                  25                  30          


Leu Leu Gly Ser Xaa Lys Arg Leu Asn Val Asn Tyr Gln Asp Ala Asp 
        35                  40                  45              


Gly Phe Ser Ala Leu His His Ala Ala Leu Gly Gly Ser Leu Glu Leu 
    50                  55                  60                  


Ile Ala Leu Leu Leu Glu Ala Gln Ala Xaa Val Asp Ile Lys Asp Ser 
65                  70                  75                  80  


Asn Gly Met Arg Pro Leu His Tyr Ala Ala Trp Gln Gly Arg Leu Glu 
                85                  90                  95      


Pro Val Arg Leu Leu Leu Arg Ala Ser Ala Ala Val Asn Ala Ala Ser 
            100                 105                 110         


Leu Asp Gly Gln Ile Pro Leu His Leu Ala Ala Gln Tyr Gly His Tyr 
        115                 120                 125             


Glu Val Ser Glu Met Leu Leu Gln His Gln Ser Asn Pro Cys Leu Val 
    130                 135                 140                 


Asn Lys Ala Lys Lys Xaa Pro Leu Asp Leu Ala Cys Glu Phe Gly Arg 
145                 150                 155                 160 


Leu Lys Val Ala Gln Leu Leu Leu Asn Ser His Leu Cys Val Ala Leu 
                165                 170                 175     


Leu Glu Gly Glu Ala Lys Asp Pro Cys Asp Pro Asn Tyr Xaa Xaa Pro 
            180                 185                 190         


Leu His Leu Ala Ala Lys Asn Gly His Arg Glu Val Ile Arg Gln Leu 
        195                 200                 205             


Leu Arg Ala Gly Ile Glu Ile Asn Arg Gln Xaa Lys Xaa Gly Xaa Ala 
    210                 215                 220                 


Leu His Glu Ala Ala Leu Tyr Gly Lys Xaa Glu Val Val Arg Leu Leu 
225                 230                 235                 240 


Leu Glu Gly Gly Val Asp Val Asn Ile Arg Asn Xaa Tyr Asn Gln Xaa 
                245                 250                 255     


Ala Leu Asp Ile Val Asn Gln Phe Xaa Xaa Ser Gln Ala Ser Arg Glu 
            260                 265                 270         


Ile Lys Gln Leu Leu Arg Glu Ala Ser Gly Ile Leu Lys Val Arg Ala 
        275                 280                 285             


Leu Lys Asp Phe Trp Asn Leu His Asp Pro Xaa Ala Leu Asn Val Arg 
    290                 295                 300                 


Ala Gly Asp Val Ile Xaa Val Arg Asp Pro Lys Gln Ala Phe Leu Cys 
305                 310                 315                 320 


Lys Tyr Lys 
            


<210> 5027
<211> 1202
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1083)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1138)..(1138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1179)..(1179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<400> 5027
Met Gly Arg Glu Gln Asp Leu Ile Leu Ala Val Lys Asn Gly Asp Val 
1               5                   10                  15      


Xaa Gly Val Gln Lys Leu Val Ala Lys Val Lys Ala Xaa Lys Xaa Lys 
            20                  25                  30          


Leu Leu Gly Ser Xaa Lys Arg Leu Asn Val Asn Tyr Gln Asp Ala Asp 
        35                  40                  45              


Gly Phe Ser Ala Leu His His Ala Ala Leu Gly Gly Ser Leu Glu Leu 
    50                  55                  60                  


Ile Ala Leu Leu Leu Glu Ala Gln Ala Xaa Val Asp Ile Lys Asp Ser 
65                  70                  75                  80  


Asn Gly Met Arg Pro Leu His Tyr Ala Ala Trp Gln Gly Arg Leu Glu 
                85                  90                  95      


Pro Val Arg Leu Leu Leu Arg Ala Ser Ala Ala Val Asn Ala Ala Ser 
            100                 105                 110         


Leu Asp Gly Gln Ile Pro Leu His Leu Ala Ala Gln Tyr Gly His Tyr 
        115                 120                 125             


Glu Val Ser Glu Met Leu Leu Gln His Gln Ser Asn Pro Cys Leu Val 
    130                 135                 140                 


Asn Lys Ala Lys Lys Xaa Pro Leu Asp Leu Ala Cys Glu Phe Gly Arg 
145                 150                 155                 160 


Leu Lys Val Ala Gln Leu Leu Leu Asn Ser His Leu Cys Val Ala Leu 
                165                 170                 175     


Leu Glu Gly Glu Ala Lys Asp Pro Cys Asp Pro Asn Tyr Xaa Xaa Pro 
            180                 185                 190         


Leu His Leu Ala Ala Lys Asn Gly His Arg Glu Val Ile Arg Gln Leu 
        195                 200                 205             


Leu Arg Ala Gly Ile Glu Ile Asn Arg Gln Xaa Lys Xaa Gly Xaa Ala 
    210                 215                 220                 


Leu His Glu Ala Ala Leu Tyr Gly Lys Xaa Glu Val Val Arg Leu Leu 
225                 230                 235                 240 


Leu Glu Gly Gly Val Asp Val Asn Ile Arg Asn Xaa Tyr Asn Gln Xaa 
                245                 250                 255     


Ala Leu Asp Ile Val Asn Gln Phe Xaa Xaa Ser Gln Ala Ser Arg Glu 
            260                 265                 270         


Ile Lys Gln Leu Leu Arg Glu Ala Ser Gly Ile Leu Lys Val Arg Ala 
        275                 280                 285             


Leu Lys Asp Phe Trp Asn Leu His Asp Pro Xaa Ala Leu Asn Val Arg 
    290                 295                 300                 


Ala Gly Asp Val Ile Xaa Val Leu Glu Gln His Pro Asp Gly Arg Trp 
305                 310                 315                 320 


Lys Gly His Ile His Glu Ser Gln Arg Gly Xaa Asp Arg Ile Gly Tyr 
                325                 330                 335     


Phe Pro Pro Gly Ile Val Glu Val Val Ser Lys Arg Val Gly Ile Pro 
            340                 345                 350         


Ala Ala Arg Leu Pro Ser Ala Pro Xaa Pro Leu Arg Pro Gly Phe Ser 
        355                 360                 365             


Arg Xaa Pro Gln Pro Pro Ala Glu Glu Pro Pro His Pro Leu Xaa Tyr 
    370                 375                 380                 


Ser Gln Leu Pro Arg Val Gly Leu Ser Pro Asp Ser Pro Ala Gly Asp 
385                 390                 395                 400 


Arg Asn Ser Val Gly Ser Glu Gly Ser Val Gly Ser Ile Arg Ser Ala 
                405                 410                 415     


Gly Ser Gly Gln Ser Ser Glu Gly Xaa Asn Gly His Gly Pro Gly Leu 
            420                 425                 430         


Leu Ile Glu Asn Ala Gln Pro Leu Pro Ser Ala Gly Glu Asp Gln Val 
        435                 440                 445             


Leu Pro Gly Leu His Pro Pro Ser Leu Ala Asp Asn Leu Ser His Arg 
    450                 455                 460                 


Pro Leu Ala Asn Cys Arg Ser Gly Glu Gln Ile Phe Xaa Gln Asp Val 
465                 470                 475                 480 


Arg Pro Glu Gln Leu Leu Glu Gly Lys Asp Ala Gln Ala Ile His Asn 
                485                 490                 495     


Trp Leu Ser Glu Phe Gln Leu Glu Gly Tyr Xaa Ala His Phe Leu Gln 
            500                 505                 510         


Ala Gly Tyr Asp Val Pro Xaa Ile Ser Arg Met Xaa Pro Glu Asp Leu 
        515                 520                 525             


Xaa Ala Ile Gly Val Xaa Lys Pro Gly His Arg Lys Lys Ile Ala Ser 
    530                 535                 540                 


Glu Ile Ala Gln Leu Ser Ile Ala Glu Trp Leu Pro Ser Tyr Ile Pro 
545                 550                 555                 560 


Xaa Asp Leu Leu Glu Trp Leu Cys Ala Leu Gly Leu Pro Gln Tyr His 
                565                 570                 575     


Lys Gln Leu Val Ser Ser Gly Tyr Asp Ser Met Gly Leu Val Ala Asp 
            580                 585                 590         


Leu Xaa Trp Glu Glu Leu Gln Glu Ile Gly Val Asn Lys Leu Gly His 
        595                 600                 605             


Gln Lys Lys Leu Met Leu Gly Val Lys Arg Leu Ala Glu Leu Arg Arg 
    610                 615                 620                 


Gly Leu Leu Gln Gly Glu Ala Leu Ser Glu Gly Gly Arg Arg Leu Ala 
625                 630                 635                 640 


Lys Gly Pro Glu Leu Met Ala Ile Glu Gly Leu Glu Asn Gly Glu Gly 
                645                 650                 655     


Pro Ala Xaa Ala Gly Pro Arg Leu Leu Xaa Phe Gln Gly Ser Glu Leu 
            660                 665                 670         


Ser Pro Glu Leu Gln Ala Ala Met Ala Gly Gly Gly Pro Glu Pro Leu 
        675                 680                 685             


Pro Leu Pro Pro Ala Arg Ser Pro Ser Gln Glu Ser Ile Gly Ala Arg 
    690                 695                 700                 


Ser Arg Gly Ser Gly His Ser Gln Glu Gln Pro Ala Pro Gln Pro Ser 
705                 710                 715                 720 


Gly Gly Asp Pro Ser Pro Pro Gln Glu Arg Asn Leu Pro Glu Gly Xaa 
                725                 730                 735     


Glu Arg Pro Pro Lys Leu Cys Ser Ser Leu Pro Gly Gln Gly Pro Pro 
            740                 745                 750         


Pro Tyr Val Phe Met Tyr Pro Gln Gly Ser Pro Ser Ser Pro Ala Pro 
        755                 760                 765             


Gly Pro Pro Pro Gly Ala Pro Trp Ala Phe Ser Tyr Leu Ala Gly Pro 
    770                 775                 780                 


Pro Ala Xaa Pro Pro Asp Pro Pro Arg Pro Lys Arg Arg Ser His Ser 
785                 790                 795                 800 


Leu Ser Arg Pro Gly Pro Xaa Glu Gly Asp Ala Glu Gly Glu Ala Glu 
                805                 810                 815     


Gly Pro Val Gly Ser Xaa Leu Gly Ser Tyr Ala Xaa Leu Xaa Arg Arg 
            820                 825                 830         


Pro Gly Arg Ser Ala Leu Val Arg Xaa Ser Pro Ser Val Xaa Pro Xaa 
        835                 840                 845             


Pro Ala Arg Gly Xaa Pro Arg Ser Gln Ser Phe Ala Leu Arg Ala Arg 
    850                 855                 860                 


Arg Lys Gly Pro Pro Pro Pro Pro Pro Lys Arg Leu Ser Ser Val Ser 
865                 870                 875                 880 


Gly Pro Ser Pro Glu Pro Pro Pro Leu Asp Glu Ser Pro Gly Pro Lys 
                885                 890                 895     


Glu Gly Ala Xaa Gly Pro Arg Arg Arg Xaa Leu Ser Glu Pro Ala Gly 
            900                 905                 910         


Pro Ser Glu Pro Pro Gly Pro Pro Ala Pro Ala Gly Pro Ala Ser Asp 
        915                 920                 925             


Xaa Glu Glu Glu Glu Pro Gly Pro Glu Gly Xaa Pro Pro Ser Arg Gly 
    930                 935                 940                 


Ser Ser Gly Glu Gly Leu Pro Phe Ala Glu Glu Gly Asn Leu Xaa Ile 
945                 950                 955                 960 


Lys Gln Arg Pro Lys Pro Ala Gly Pro Pro Pro Arg Glu Xaa Pro Val 
                965                 970                 975     


Pro Pro Gly Leu Asp Phe Asn Leu Xaa Glu Ser Asp Xaa Val Lys Arg 
            980                 985                 990         


Arg Pro Lys Cys Arg Glu Arg Glu  Pro Leu Gln Xaa Ala  Leu Leu Ala 
        995                 1000                 1005             


Phe Gly  Val Ala Ser Ala Xaa  Pro Gly Pro Ala Ala  Pro Leu Pro 
    1010                 1015                 1020             


Ser Pro  Xaa Pro Gly Glu Ser  Pro Pro Ala Ser Ser  Leu Pro Gln 
    1025                 1030                 1035             


Pro Glu  Pro Ser Ser Leu Pro  Ala Gln Gly Val Pro  Xaa Pro Leu 
    1040                 1045                 1050             


Ala Pro  Ser Pro Ala Met Gln  Pro Pro Val Pro Pro  Cys Pro Gly 
    1055                 1060                 1065             


Pro Gly  Leu Glu Ser Ser Ala  Ala Ser Arg Trp Asn  Gly Glu Xaa 
    1070                 1075                 1080             


Glu Pro  Pro Ala Ala Pro Ala  Ala Leu Leu Lys Val  Pro Gly Ala 
    1085                 1090                 1095             


Gly Xaa  Ala Pro Lys Pro Val  Ser Val Ala Cys Xaa  Gln Leu Ala 
    1100                 1105                 1110             


Phe Ser  Gly Pro Lys Leu Ala  Pro Arg Leu Gly Pro  Arg Pro Val 
    1115                 1120                 1125             


Pro Pro  Pro Arg Pro Glu Ser  Xaa Gly Xaa Val Gly  Pro Gly Gln 
    1130                 1135                 1140             


Ala Gln  Gln Arg Leu Glu Gln  Xaa Ser Ser Ser Leu  Ala Ala Ala 
    1145                 1150                 1155             


Leu Arg  Ala Ala Glu Lys Ser  Ile Gly Xaa Lys Glu  Gln Glu Gly 
    1160                 1165                 1170             


Xaa Pro  Ser Ala Ser Xaa Lys  His Ile Leu Asp Asp  Ile Ser Xaa 
    1175                 1180                 1185             


Met Phe  Asp Ala Leu Ala Asp  Gln Leu Asp Ala Met  Leu Asp 
    1190                 1195                 1200         


<210> 5028
<211> 1120
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1106)..(1106)
<223> Selenocysteine

<400> 5028
Met Arg Pro Leu His Tyr Ala Ala Trp Gln Gly Arg Leu Glu Pro Val 
1               5                   10                  15      


Arg Leu Leu Leu Arg Ala Ser Ala Ala Val Asn Ala Ala Ser Leu Asp 
            20                  25                  30          


Gly Gln Ile Pro Leu His Leu Ala Ala Gln Tyr Gly His Tyr Glu Val 
        35                  40                  45              


Ser Glu Met Leu Leu Gln His Gln Ser Asn Pro Cys Leu Val Asn Lys 
    50                  55                  60                  


Ala Lys Lys Xaa Pro Leu Asp Leu Ala Cys Glu Phe Gly Arg Leu Lys 
65                  70                  75                  80  


Val Ala Gln Leu Leu Leu Asn Ser His Leu Cys Val Ala Leu Leu Glu 
                85                  90                  95      


Gly Glu Ala Lys Asp Pro Cys Asp Pro Asn Tyr Xaa Xaa Pro Leu His 
            100                 105                 110         


Leu Ala Ala Lys Asn Gly His Arg Glu Val Ile Arg Gln Leu Leu Arg 
        115                 120                 125             


Ala Gly Ile Glu Ile Asn Arg Gln Xaa Lys Xaa Gly Xaa Ala Leu His 
    130                 135                 140                 


Glu Ala Ala Leu Tyr Gly Lys Xaa Glu Val Val Arg Leu Leu Leu Glu 
145                 150                 155                 160 


Gly Gly Val Asp Val Asn Ile Arg Asn Xaa Tyr Asn Gln Xaa Ala Leu 
                165                 170                 175     


Asp Ile Val Asn Gln Phe Xaa Xaa Ser Gln Ala Ser Arg Glu Ile Lys 
            180                 185                 190         


Gln Leu Leu Arg Glu Ala Ser Gly Ile Leu Lys Val Arg Ala Leu Lys 
        195                 200                 205             


Asp Phe Trp Asn Leu His Asp Pro Xaa Ala Leu Asn Val Arg Ala Gly 
    210                 215                 220                 


Asp Val Ile Xaa Val Leu Glu Gln His Pro Asp Gly Arg Trp Lys Gly 
225                 230                 235                 240 


His Ile His Glu Ser Gln Arg Gly Xaa Asp Arg Ile Gly Tyr Phe Pro 
                245                 250                 255     


Pro Gly Ile Val Glu Val Val Ser Lys Arg Val Gly Ile Pro Ala Ala 
            260                 265                 270         


Arg Leu Pro Ser Ala Pro Xaa Pro Leu Arg Pro Gly Phe Ser Arg Xaa 
        275                 280                 285             


Pro Gln Pro Pro Ala Glu Glu Pro Pro His Pro Leu Xaa Tyr Ser Gln 
    290                 295                 300                 


Leu Pro Arg Val Gly Leu Ser Pro Asp Ser Pro Ala Gly Asp Arg Asn 
305                 310                 315                 320 


Ser Val Gly Ser Glu Gly Ser Val Gly Ser Ile Arg Ser Ala Gly Ser 
                325                 330                 335     


Gly Gln Ser Ser Glu Gly Xaa Asn Gly His Gly Pro Gly Leu Leu Ile 
            340                 345                 350         


Glu Asn Ala Gln Pro Leu Pro Ser Ala Gly Glu Asp Gln Val Leu Pro 
        355                 360                 365             


Gly Leu His Pro Pro Ser Leu Ala Asp Asn Leu Ser His Arg Pro Leu 
    370                 375                 380                 


Ala Asn Cys Arg Ser Gly Glu Gln Ile Phe Xaa Gln Asp Val Arg Pro 
385                 390                 395                 400 


Glu Gln Leu Leu Glu Gly Lys Asp Ala Gln Ala Ile His Asn Trp Leu 
                405                 410                 415     


Ser Glu Phe Gln Leu Glu Gly Tyr Xaa Ala His Phe Leu Gln Ala Gly 
            420                 425                 430         


Tyr Asp Val Pro Xaa Ile Ser Arg Met Xaa Pro Glu Asp Leu Xaa Ala 
        435                 440                 445             


Ile Gly Val Xaa Lys Pro Gly His Arg Lys Lys Ile Ala Ser Glu Ile 
    450                 455                 460                 


Ala Gln Leu Ser Ile Ala Glu Trp Leu Pro Ser Tyr Ile Pro Xaa Asp 
465                 470                 475                 480 


Leu Leu Glu Trp Leu Cys Ala Leu Gly Leu Pro Gln Tyr His Lys Gln 
                485                 490                 495     


Leu Val Ser Ser Gly Tyr Asp Ser Met Gly Leu Val Ala Asp Leu Xaa 
            500                 505                 510         


Trp Glu Glu Leu Gln Glu Ile Gly Val Asn Lys Leu Gly His Gln Lys 
        515                 520                 525             


Lys Leu Met Leu Gly Val Lys Arg Leu Ala Glu Leu Arg Arg Gly Leu 
    530                 535                 540                 


Leu Gln Gly Glu Ala Leu Ser Glu Gly Gly Arg Arg Leu Ala Lys Gly 
545                 550                 555                 560 


Pro Glu Leu Met Ala Ile Glu Gly Leu Glu Asn Gly Glu Gly Pro Ala 
                565                 570                 575     


Xaa Ala Gly Pro Arg Leu Leu Xaa Phe Gln Gly Ser Glu Leu Ser Pro 
            580                 585                 590         


Glu Leu Gln Ala Ala Met Ala Gly Gly Gly Pro Glu Pro Leu Pro Leu 
        595                 600                 605             


Pro Pro Ala Arg Ser Pro Ser Gln Glu Ser Ile Gly Ala Arg Ser Arg 
    610                 615                 620                 


Gly Ser Gly His Ser Gln Glu Gln Pro Ala Pro Gln Pro Ser Gly Gly 
625                 630                 635                 640 


Asp Pro Ser Pro Pro Gln Glu Arg Asn Leu Pro Glu Gly Xaa Glu Arg 
                645                 650                 655     


Pro Pro Lys Leu Cys Ser Ser Leu Pro Gly Gln Gly Pro Pro Pro Tyr 
            660                 665                 670         


Val Phe Met Tyr Pro Gln Gly Ser Pro Ser Ser Pro Ala Pro Gly Pro 
        675                 680                 685             


Pro Pro Gly Ala Pro Trp Ala Phe Ser Tyr Leu Ala Gly Pro Pro Ala 
    690                 695                 700                 


Xaa Pro Pro Asp Pro Pro Arg Pro Lys Arg Arg Ser His Ser Leu Ser 
705                 710                 715                 720 


Arg Pro Gly Pro Xaa Glu Gly Asp Ala Glu Gly Glu Ala Glu Gly Pro 
                725                 730                 735     


Val Gly Ser Xaa Leu Gly Ser Tyr Ala Xaa Leu Xaa Arg Arg Pro Gly 
            740                 745                 750         


Arg Ser Ala Leu Val Arg Xaa Ser Pro Ser Val Xaa Pro Xaa Pro Ala 
        755                 760                 765             


Arg Gly Xaa Pro Arg Ser Gln Ser Phe Ala Leu Arg Ala Arg Arg Lys 
    770                 775                 780                 


Gly Pro Pro Pro Pro Pro Pro Lys Arg Leu Ser Ser Val Ser Gly Pro 
785                 790                 795                 800 


Ser Pro Glu Pro Pro Pro Leu Asp Glu Ser Pro Gly Pro Lys Glu Gly 
                805                 810                 815     


Ala Xaa Gly Pro Arg Arg Arg Xaa Leu Ser Glu Pro Ala Gly Pro Ser 
            820                 825                 830         


Glu Pro Pro Gly Pro Pro Ala Pro Ala Gly Pro Ala Ser Asp Xaa Glu 
        835                 840                 845             


Glu Glu Glu Pro Gly Pro Glu Gly Xaa Pro Pro Ser Arg Gly Ser Ser 
    850                 855                 860                 


Gly Glu Gly Leu Pro Phe Ala Glu Glu Gly Asn Leu Xaa Ile Lys Gln 
865                 870                 875                 880 


Arg Pro Lys Pro Ala Gly Pro Pro Pro Arg Glu Xaa Pro Val Pro Pro 
                885                 890                 895     


Gly Leu Asp Phe Asn Leu Xaa Glu Ser Asp Xaa Val Lys Arg Arg Pro 
            900                 905                 910         


Lys Cys Arg Glu Arg Glu Pro Leu Gln Xaa Ala Leu Leu Ala Phe Gly 
        915                 920                 925             


Val Ala Ser Ala Xaa Pro Gly Pro Ala Ala Pro Leu Pro Ser Pro Xaa 
    930                 935                 940                 


Pro Gly Glu Ser Pro Pro Ala Ser Ser Leu Pro Gln Pro Glu Pro Ser 
945                 950                 955                 960 


Ser Leu Pro Ala Gln Gly Val Pro Xaa Pro Leu Ala Pro Ser Pro Ala 
                965                 970                 975     


Met Gln Pro Pro Val Pro Pro Cys Pro Gly Pro Gly Leu Glu Ser Ser 
            980                 985                 990         


Ala Ala Ser Arg Trp Asn Gly Glu  Xaa Glu Pro Pro Ala  Ala Pro Ala 
        995                 1000                 1005             


Ala Leu  Leu Lys Val Pro Gly  Ala Gly Xaa Ala Pro  Lys Pro Val 
    1010                 1015                 1020             


Ser Val  Ala Cys Xaa Gln Leu  Ala Phe Ser Gly Pro  Lys Leu Ala 
    1025                 1030                 1035             


Pro Arg  Leu Gly Pro Arg Pro  Val Pro Pro Pro Arg  Pro Glu Ser 
    1040                 1045                 1050             


Xaa Gly  Xaa Val Gly Pro Gly  Gln Ala Gln Gln Arg  Leu Glu Gln 
    1055                 1060                 1065             


Xaa Ser  Ser Ser Leu Ala Ala  Ala Leu Arg Ala Ala  Glu Lys Ser 
    1070                 1075                 1080             


Ile Gly  Xaa Lys Glu Gln Glu  Gly Xaa Pro Ser Ala  Ser Xaa Lys 
    1085                 1090                 1095             


His Ile  Leu Asp Asp Ile Ser  Xaa Met Phe Asp Ala  Leu Ala Asp 
    1100                 1105                 1110             


Gln Leu  Asp Ala Met Leu Asp  
    1115                 1120 


<210> 5029
<211> 236
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<400> 5029
Ile Tyr Pro Ile Met Asp Lys Ser Ser Arg Xaa Arg Leu Ala Leu Ile 
1               5                   10                  15      


Ile Cys Asn Glu Glu Phe Asp Ser Ile Pro Arg Arg Xaa Gly Ala Glu 
            20                  25                  30          


Val Asp Ile Xaa Gly Met Xaa Met Leu Leu Gln Asn Leu Gly Tyr Ser 
        35                  40                  45              


Val Asp Val Lys Lys Asn Leu Xaa Ala Ser Asp Met Xaa Xaa Glu Leu 
    50                  55                  60                  


Glu Ala Phe Ala His Arg Pro Glu His Lys Xaa Ser Asp Ser Xaa Phe 
65                  70                  75                  80  


Leu Val Phe Met Ser His Gly Ile Arg Glu Gly Ile Cys Gly Lys Lys 
                85                  90                  95      


His Ser Glu Gln Val Pro Asp Ile Leu Gln Leu Asn Ala Ile Phe Asn 
            100                 105                 110         


Met Leu Asn Xaa Lys Asn Cys Pro Ser Leu Lys Asp Lys Pro Lys Val 
        115                 120                 125             


Ile Ile Ile Gln Ala Cys Arg Gly Asp Ser Pro Gly Val Val Trp Phe 
    130                 135                 140                 


Lys Asp Ser Val Gly Val Ser Gly Asn Leu Ser Leu Pro Xaa Xaa Glu 
145                 150                 155                 160 


Glu Phe Glu Asp Asp Ala Ile Lys Lys Ala His Ile Glu Lys Asp Phe 
                165                 170                 175     


Ile Ala Phe Cys Ser Ser Xaa Pro Asp Asn Val Ser Trp Arg His Pro 
            180                 185                 190         


Xaa Met Gly Ser Val Phe Ile Gly Arg Leu Ile Glu His Met Gln Glu 
        195                 200                 205             


Tyr Ala Cys Ser Cys Asp Val Glu Glu Ile Phe Arg Lys Glu Val Lys 
    210                 215                 220                 


Arg Ser Phe Cys Lys Gly Phe Trp Asn Tyr Val Cys 
225                 230                 235     


<210> 5030
<211> 263
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<400> 5030
Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile Arg Ser 
1               5                   10                  15      


Met Gly Glu Ala Pro Gln Ala Val Gln Asp Asn Pro Ala Met Pro Xaa 
            20                  25                  30          


Ser Ser Gly Ser Glu Gly Asn Val Lys Leu Cys Ser Leu Glu Glu Ala 
        35                  40                  45              


Gln Arg Ile Trp Lys Gln Lys Ser Ala Glu Ile Tyr Pro Ile Met Asp 
    50                  55                  60                  


Lys Ser Ser Arg Xaa Arg Leu Ala Leu Ile Ile Cys Asn Glu Glu Phe 
65                  70                  75                  80  


Asp Ser Ile Pro Arg Arg Xaa Gly Ala Glu Val Asp Ile Xaa Gly Met 
                85                  90                  95      


Xaa Met Leu Leu Gln Asn Leu Gly Tyr Ser Val Asp Val Lys Lys Asn 
            100                 105                 110         


Leu Xaa Ala Ser Asp Met Xaa Xaa Glu Leu Glu Ala Phe Ala His Arg 
        115                 120                 125             


Pro Glu His Lys Xaa Ser Asp Ser Xaa Phe Leu Val Phe Met Ser His 
    130                 135                 140                 


Gly Ile Arg Glu Gly Ile Cys Gly Lys Lys His Ser Glu Gln Val Pro 
145                 150                 155                 160 


Asp Ile Leu Gln Leu Asn Ala Ile Phe Asn Met Leu Asn Xaa Lys Asn 
                165                 170                 175     


Cys Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala Cys 
            180                 185                 190         


Arg Gly Asp Asn Val Ser Trp Arg His Pro Xaa Met Gly Ser Val Phe 
        195                 200                 205             


Ile Gly Arg Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser Cys Asp 
    210                 215                 220                 


Val Glu Glu Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Asp 
225                 230                 235                 240 


Gly Arg Ala Gln Met Pro Xaa Xaa Glu Arg Val Xaa Leu Xaa Arg Cys 
                245                 250                 255     


Phe Tyr Leu Phe Pro Gly His 
            260             


<210> 5031
<211> 311
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<400> 5031
Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile Arg Ser 
1               5                   10                  15      


Met Gly Glu Ala Pro Gln Ala Val Gln Asp Asn Pro Ala Met Pro Xaa 
            20                  25                  30          


Ser Ser Gly Ser Glu Gly Asn Val Lys Leu Cys Ser Leu Glu Glu Ala 
        35                  40                  45              


Gln Arg Ile Trp Lys Gln Lys Ser Ala Glu Ile Tyr Pro Ile Met Asp 
    50                  55                  60                  


Lys Ser Ser Arg Xaa Arg Leu Ala Leu Ile Ile Cys Asn Glu Glu Phe 
65                  70                  75                  80  


Asp Ser Ile Pro Arg Arg Xaa Gly Ala Glu Val Asp Ile Xaa Gly Met 
                85                  90                  95      


Xaa Met Leu Leu Gln Asn Leu Gly Tyr Ser Val Asp Val Lys Lys Asn 
            100                 105                 110         


Leu Xaa Ala Ser Asp Met Xaa Xaa Glu Leu Glu Ala Phe Ala His Arg 
        115                 120                 125             


Pro Glu His Lys Xaa Ser Asp Ser Xaa Phe Leu Val Phe Met Ser His 
    130                 135                 140                 


Gly Ile Arg Glu Gly Ile Cys Gly Lys Lys His Ser Glu Gln Val Pro 
145                 150                 155                 160 


Asp Ile Leu Gln Leu Asn Ala Ile Phe Asn Met Leu Asn Xaa Lys Asn 
                165                 170                 175     


Cys Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala Cys 
            180                 185                 190         


Arg Gly Asp Ser Pro Gly Val Val Trp Phe Lys Asp Ser Val Gly Val 
        195                 200                 205             


Ser Gly Asn Leu Ser Leu Pro Xaa Xaa Glu Glu Phe Glu Asp Asp Ala 
    210                 215                 220                 


Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser 
225                 230                 235                 240 


Xaa Pro Asp Asn Val Ser Trp Arg His Pro Xaa Met Gly Ser Val Phe 
                245                 250                 255     


Ile Gly Arg Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser Cys Asp 
            260                 265                 270         


Val Glu Glu Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Asp 
        275                 280                 285             


Gly Arg Ala Gln Met Pro Xaa Xaa Glu Arg Val Xaa Leu Xaa Arg Cys 
    290                 295                 300                 


Phe Tyr Leu Phe Pro Gly His 
305                 310     


<210> 5032
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<400> 5032
Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile Arg Ser 
1               5                   10                  15      


Met Gly Glu Asp Asn Val Ser Trp Arg His Pro Xaa Met Gly Ser Val 
            20                  25                  30          


Phe Ile Gly Arg Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser Cys 
        35                  40                  45              


Asp Val Glu Glu Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro 
    50                  55                  60                  


Asp Gly Arg Ala Gln Met Pro Xaa Xaa Glu Arg Val Xaa Leu Xaa Arg 
65                  70                  75                  80  


Cys Phe Tyr Leu Phe Pro Gly His 
                85              


<210> 5033
<211> 383
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<400> 5033
Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile Arg Ser 
1               5                   10                  15      


Met Gly Glu Gly Xaa Ile Asn Gly Leu Leu Asp Glu Leu Leu Gln Xaa 
            20                  25                  30          


Arg Val Leu Asn Lys Glu Glu Met Glu Lys Val Lys Arg Glu Asn Ala 
        35                  40                  45              


Xaa Val Met Asp Lys Xaa Arg Ala Leu Ile Asp Ser Val Ile Pro Lys 
    50                  55                  60                  


Gly Ala Gln Ala Cys Gln Ile Cys Ile Xaa Tyr Ile Cys Glu Glu Asp 
65                  70                  75                  80  


Ser Tyr Leu Ala Gly Xaa Leu Gly Leu Ser Ala Ala Pro Gln Ala Val 
                85                  90                  95      


Gln Asp Asn Pro Ala Met Pro Xaa Ser Ser Gly Ser Glu Gly Asn Val 
            100                 105                 110         


Lys Leu Cys Ser Leu Glu Glu Ala Gln Arg Ile Trp Lys Gln Lys Ser 
        115                 120                 125             


Ala Glu Ile Tyr Pro Ile Met Asp Lys Ser Ser Arg Xaa Arg Leu Ala 
    130                 135                 140                 


Leu Ile Ile Cys Asn Glu Glu Phe Asp Ser Ile Pro Arg Arg Xaa Gly 
145                 150                 155                 160 


Ala Glu Val Asp Ile Xaa Gly Met Xaa Met Leu Leu Gln Asn Leu Gly 
                165                 170                 175     


Tyr Ser Val Asp Val Lys Lys Asn Leu Xaa Ala Ser Asp Met Xaa Xaa 
            180                 185                 190         


Glu Leu Glu Ala Phe Ala His Arg Pro Glu His Lys Xaa Ser Asp Ser 
        195                 200                 205             


Xaa Phe Leu Val Phe Met Ser His Gly Ile Arg Glu Gly Ile Cys Gly 
    210                 215                 220                 


Lys Lys His Ser Glu Gln Val Pro Asp Ile Leu Gln Leu Asn Ala Ile 
225                 230                 235                 240 


Phe Asn Met Leu Asn Xaa Lys Asn Cys Pro Ser Leu Lys Asp Lys Pro 
                245                 250                 255     


Lys Val Ile Ile Ile Gln Ala Cys Arg Gly Asp Ser Pro Gly Val Val 
            260                 265                 270         


Trp Phe Lys Asp Ser Val Gly Val Ser Gly Asn Leu Ser Leu Pro Xaa 
        275                 280                 285             


Xaa Glu Glu Phe Glu Asp Asp Ala Ile Lys Lys Ala His Ile Glu Lys 
    290                 295                 300                 


Asp Phe Ile Ala Phe Cys Ser Ser Xaa Pro Asp Asn Val Ser Trp Arg 
305                 310                 315                 320 


His Pro Xaa Met Gly Ser Val Phe Ile Gly Arg Leu Ile Glu His Met 
                325                 330                 335     


Gln Glu Tyr Ala Cys Ser Cys Asp Val Glu Glu Ile Phe Arg Lys Val 
            340                 345                 350         


Arg Phe Ser Phe Glu Gln Pro Asp Gly Arg Ala Gln Met Pro Xaa Xaa 
        355                 360                 365             


Glu Arg Val Xaa Leu Xaa Arg Cys Phe Tyr Leu Phe Pro Gly His 
    370                 375                 380             


<210> 5034
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 5034
Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile Arg Ser 
1               5                   10                  15      


Met Gly Glu Gly Xaa Ile Asn Gly Leu Leu Asp Glu Leu Leu Gln Xaa 
            20                  25                  30          


Arg Val Leu Asn Lys Glu Glu Met Glu Lys Val Lys Arg Glu Asn Ala 
        35                  40                  45              


Xaa Val Met Asp Lys Xaa Arg Ala Leu Ile Asp Ser Val Ile Pro Lys 
    50                  55                  60                  


Gly Ala Gln Ala Cys Gln Ile Cys Ile Xaa Tyr Ile Cys Glu Glu Asp 
65                  70                  75                  80  


Ser Tyr Leu Ala Gly Xaa Leu Gly Leu Ser Ala Asp Leu Ser Asn Asn 
                85                  90                  95      


Gly Gln Val Lys Pro His Xaa Ser Cys Ser His Tyr Leu Gln 
            100                 105                 110 


<210> 5035
<211> 404
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<400> 5035
Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile Arg Ser 
1               5                   10                  15      


Met Gly Glu Gly Xaa Ile Asn Gly Leu Leu Asp Glu Leu Leu Gln Xaa 
            20                  25                  30          


Arg Val Leu Asn Lys Glu Glu Met Glu Lys Val Lys Arg Glu Asn Ala 
        35                  40                  45              


Xaa Val Met Asp Lys Xaa Arg Ala Leu Ile Asp Ser Val Ile Pro Lys 
    50                  55                  60                  


Gly Ala Gln Ala Cys Gln Ile Cys Ile Xaa Tyr Ile Cys Glu Glu Asp 
65                  70                  75                  80  


Ser Tyr Leu Ala Gly Xaa Leu Gly Leu Ser Ala Asp Gln Xaa Ser Gly 
                85                  90                  95      


Asn Tyr Leu Asn Met Gln Asp Ser Gln Gly Val Leu Ser Ser Phe Pro 
            100                 105                 110         


Ala Pro Gln Ala Val Gln Asp Asn Pro Ala Met Pro Xaa Ser Ser Gly 
        115                 120                 125             


Ser Glu Gly Asn Val Lys Leu Cys Ser Leu Glu Glu Ala Gln Arg Ile 
    130                 135                 140                 


Trp Lys Gln Lys Ser Ala Glu Ile Tyr Pro Ile Met Asp Lys Ser Ser 
145                 150                 155                 160 


Arg Xaa Arg Leu Ala Leu Ile Ile Cys Asn Glu Glu Phe Asp Ser Ile 
                165                 170                 175     


Pro Arg Arg Xaa Gly Ala Glu Val Asp Ile Xaa Gly Met Xaa Met Leu 
            180                 185                 190         


Leu Gln Asn Leu Gly Tyr Ser Val Asp Val Lys Lys Asn Leu Xaa Ala 
        195                 200                 205             


Ser Asp Met Xaa Xaa Glu Leu Glu Ala Phe Ala His Arg Pro Glu His 
    210                 215                 220                 


Lys Xaa Ser Asp Ser Xaa Phe Leu Val Phe Met Ser His Gly Ile Arg 
225                 230                 235                 240 


Glu Gly Ile Cys Gly Lys Lys His Ser Glu Gln Val Pro Asp Ile Leu 
                245                 250                 255     


Gln Leu Asn Ala Ile Phe Asn Met Leu Asn Xaa Lys Asn Cys Pro Ser 
            260                 265                 270         


Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala Cys Arg Gly Asp 
        275                 280                 285             


Ser Pro Gly Val Val Trp Phe Lys Asp Ser Val Gly Val Ser Gly Asn 
    290                 295                 300                 


Leu Ser Leu Pro Xaa Xaa Glu Glu Phe Glu Asp Asp Ala Ile Lys Lys 
305                 310                 315                 320 


Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser Xaa Pro Asp 
                325                 330                 335     


Asn Val Ser Trp Arg His Pro Xaa Met Gly Ser Val Phe Ile Gly Arg 
            340                 345                 350         


Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser Cys Asp Val Glu Glu 
        355                 360                 365             


Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Asp Gly Arg Ala 
    370                 375                 380                 


Gln Met Pro Xaa Xaa Glu Arg Val Xaa Leu Xaa Arg Cys Phe Tyr Leu 
385                 390                 395                 400 


Phe Pro Gly His 
                


<210> 5036
<211> 301
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<400> 5036
Met Glu Lys Val Lys Arg Glu Asn Ala Xaa Val Met Asp Lys Xaa Arg 
1               5                   10                  15      


Ala Leu Ile Asp Ser Val Ile Pro Lys Gly Ala Gln Ala Cys Gln Ile 
            20                  25                  30          


Cys Ile Xaa Tyr Ile Cys Glu Glu Asp Ser Tyr Leu Ala Gly Xaa Leu 
        35                  40                  45              


Gly Leu Ser Ala Asp Gln Xaa Ser Gly Asn Tyr Leu Asn Met Gln Asp 
    50                  55                  60                  


Ser Gln Gly Val Leu Ser Ser Phe Pro Ala Pro Gln Ala Val Gln Asp 
65                  70                  75                  80  


Asn Pro Ala Met Pro Xaa Ser Ser Gly Ser Glu Gly Asn Val Lys Leu 
                85                  90                  95      


Cys Ser Leu Glu Glu Ala Gln Arg Ile Trp Lys Gln Lys Ser Ala Glu 
            100                 105                 110         


Ile Tyr Pro Ile Met Asp Lys Ser Ser Arg Xaa Arg Leu Ala Leu Ile 
        115                 120                 125             


Ile Cys Asn Glu Glu Phe Asp Ser Ile Pro Arg Arg Xaa Gly Ala Glu 
    130                 135                 140                 


Val Asp Ile Xaa Gly Met Xaa Met Leu Leu Gln Asn Leu Gly Tyr Ser 
145                 150                 155                 160 


Val Asp Val Lys Lys Asn Leu Xaa Ala Ser Asp Met Xaa Xaa Glu Leu 
                165                 170                 175     


Glu Ala Phe Ala His Arg Pro Glu His Lys Xaa Ser Asp Ser Xaa Phe 
            180                 185                 190         


Leu Val Phe Met Ser His Gly Ile Arg Glu Gly Ile Cys Gly Lys Lys 
        195                 200                 205             


His Ser Glu Gln Val Pro Asp Ile Leu Gln Leu Asn Ala Ile Phe Asn 
    210                 215                 220                 


Met Leu Asn Xaa Lys Asn Cys Pro Ser Leu Lys Asp Lys Pro Lys Val 
225                 230                 235                 240 


Ile Ile Ile Gln Ala Cys Arg Gly Asp Ser Pro Gly Val Val Trp Phe 
                245                 250                 255     


Lys Asp Ser Val Gly Val Ser Gly Asn Leu Ser Leu Pro Xaa Xaa Glu 
            260                 265                 270         


Glu Phe Glu Asp Asp Ala Ile Lys Lys Ala His Ile Glu Lys Asp Phe 
        275                 280                 285             


Ile Ala Phe Cys Ser Ser Xaa Pro Gly Lys Ser Gln Ser 
    290                 295                 300     


<210> 5037
<211> 367
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<400> 5037
Met Gly Glu Gly Xaa Ile Asn Gly Leu Leu Asp Glu Leu Leu Gln Xaa 
1               5                   10                  15      


Arg Val Leu Asn Lys Glu Glu Met Glu Lys Val Lys Arg Glu Asn Ala 
            20                  25                  30          


Xaa Val Met Asp Lys Xaa Arg Ala Leu Ile Asp Ser Val Ile Pro Lys 
        35                  40                  45              


Gly Ala Gln Ala Cys Gln Ile Cys Ile Xaa Tyr Ile Cys Glu Glu Asp 
    50                  55                  60                  


Ser Tyr Leu Ala Gly Xaa Leu Gly Leu Ser Ala Ala Pro Gln Ala Val 
65                  70                  75                  80  


Gln Asp Asn Pro Ala Met Pro Xaa Ser Ser Gly Ser Glu Gly Asn Val 
                85                  90                  95      


Lys Leu Cys Ser Leu Glu Glu Ala Gln Arg Ile Trp Lys Gln Lys Ser 
            100                 105                 110         


Ala Glu Ile Tyr Pro Ile Met Asp Lys Ser Ser Arg Xaa Arg Leu Ala 
        115                 120                 125             


Leu Ile Ile Cys Asn Glu Glu Phe Asp Ser Ile Pro Arg Arg Xaa Gly 
    130                 135                 140                 


Ala Glu Val Asp Ile Xaa Gly Met Xaa Met Leu Leu Gln Asn Leu Gly 
145                 150                 155                 160 


Tyr Ser Val Asp Val Lys Lys Asn Leu Xaa Ala Ser Asp Met Xaa Xaa 
                165                 170                 175     


Glu Leu Glu Ala Phe Ala His Arg Pro Glu His Lys Xaa Ser Asp Ser 
            180                 185                 190         


Xaa Phe Leu Val Phe Met Ser His Gly Ile Arg Glu Gly Ile Cys Gly 
        195                 200                 205             


Lys Lys His Ser Glu Gln Val Pro Asp Ile Leu Gln Leu Asn Ala Ile 
    210                 215                 220                 


Phe Asn Met Leu Asn Xaa Lys Asn Cys Pro Ser Leu Lys Asp Lys Pro 
225                 230                 235                 240 


Lys Val Ile Ile Ile Gln Ala Cys Arg Gly Asp Ser Pro Gly Val Val 
                245                 250                 255     


Trp Phe Lys Asp Ser Val Gly Val Ser Gly Asn Leu Ser Leu Pro Xaa 
            260                 265                 270         


Xaa Glu Glu Phe Glu Asp Asp Ala Ile Lys Lys Ala His Ile Glu Lys 
        275                 280                 285             


Asp Phe Ile Ala Phe Cys Ser Ser Xaa Pro Asp Asn Val Ser Trp Arg 
    290                 295                 300                 


His Pro Xaa Met Gly Ser Val Phe Ile Gly Arg Leu Ile Glu His Met 
305                 310                 315                 320 


Gln Glu Tyr Ala Cys Ser Cys Asp Val Glu Glu Ile Phe Arg Lys Val 
                325                 330                 335     


Arg Phe Ser Phe Glu Gln Pro Asp Gly Arg Ala Gln Met Pro Xaa Xaa 
            340                 345                 350         


Glu Arg Val Xaa Leu Xaa Arg Cys Phe Tyr Leu Phe Pro Gly His 
        355                 360                 365         


<210> 5038
<211> 247
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<400> 5038
Met Lys Ser Gln Gly Gln His Trp Tyr Ser Ser Ser Asp Lys Asn Cys 
1               5                   10                  15      


Lys Val Ser Phe Arg Glu Lys Leu Leu Ile Ile Asp Ser Asn Leu Gly 
            20                  25                  30          


Val Gln Asp Val Glu Asn Leu Lys Phe Leu Cys Ile Gly Leu Val Pro 
        35                  40                  45              


Asn Lys Lys Leu Glu Lys Ser Ser Ser Ala Ser Asp Val Phe Glu His 
    50                  55                  60                  


Leu Leu Ala Glu Asp Leu Leu Ser Glu Glu Asp Pro Phe Phe Leu Ala 
65                  70                  75                  80  


Glu Leu Leu Tyr Ile Ile Arg Gln Lys Lys Leu Leu Gln His Leu Asn 
                85                  90                  95      


Cys Xaa Lys Glu Glu Val Glu Arg Leu Leu Pro Xaa Arg Gln Arg Val 
            100                 105                 110         


Ser Leu Phe Arg Asn Leu Leu Tyr Glu Leu Ser Glu Gly Ile Asp Ser 
        115                 120                 125             


Glu Asn Leu Lys Asp Met Ile Phe Leu Leu Lys Asp Ser Leu Pro Lys 
    130                 135                 140                 


Xaa Glu Met Xaa Ser Leu Ser Phe Leu Ala Phe Leu Glu Lys Gln Gly 
145                 150                 155                 160 


Lys Ile Asp Glu Asp Asn Leu Xaa Cys Leu Glu Asp Leu Cys Lys Xaa 
                165                 170                 175     


Val Val Pro Lys Leu Leu Arg Asn Ile Glu Lys Tyr Lys Arg Glu Lys 
            180                 185                 190         


Ala Ile Gln Ile Val Xaa Pro Pro Val Asp Lys Glu Ala Glu Ser Tyr 
        195                 200                 205             


Gln Gly Glu Glu Glu Leu Val Ser Gln Xaa Asp Val Lys Xaa Phe Leu 
    210                 215                 220                 


Glu Ala Leu Pro Glu Gly Val Phe Val Phe Leu Asn Glu Gly Asp Arg 
225                 230                 235                 240 


Gly Asn Ser Pro Asp Asp Leu 
                245         


<210> 5039
<211> 273
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<400> 5039
Met Lys Ser Gln Gly Gln His Trp Tyr Ser Ser Ser Asp Lys Asn Cys 
1               5                   10                  15      


Lys Val Ser Phe Arg Glu Lys Leu Leu Ile Ile Asp Ser Asn Leu Gly 
            20                  25                  30          


Val Gln Asp Val Glu Asn Leu Lys Phe Leu Cys Ile Gly Leu Val Pro 
        35                  40                  45              


Asn Lys Lys Leu Glu Lys Ser Ser Ser Ala Ser Asp Val Phe Glu His 
    50                  55                  60                  


Leu Leu Ala Glu Asp Leu Leu Ser Glu Glu Asp Pro Phe Phe Leu Ala 
65                  70                  75                  80  


Glu Leu Leu Tyr Ile Ile Arg Gln Lys Lys Leu Leu Gln His Leu Asn 
                85                  90                  95      


Cys Xaa Lys Glu Glu Val Glu Arg Leu Leu Pro Xaa Arg Gln Arg Val 
            100                 105                 110         


Ser Leu Phe Arg Asn Leu Leu Tyr Glu Leu Ser Glu Gly Ile Asp Ser 
        115                 120                 125             


Glu Asn Leu Lys Asp Met Ile Phe Leu Leu Lys Asp Ser Leu Pro Lys 
    130                 135                 140                 


Xaa Glu Met Xaa Ser Leu Ser Phe Leu Ala Phe Leu Glu Lys Gln Gly 
145                 150                 155                 160 


Lys Ile Asp Glu Asp Asn Leu Xaa Cys Leu Glu Asp Leu Cys Lys Xaa 
                165                 170                 175     


Val Val Pro Lys Leu Leu Arg Asn Ile Glu Lys Tyr Lys Arg Glu Lys 
            180                 185                 190         


Ala Ile Gln Ile Val Xaa Pro Pro Val Asp Lys Glu Ala Glu Ser Tyr 
        195                 200                 205             


Gln Gly Glu Glu Glu Leu Val Ser Gln Xaa Asp Val Lys Xaa Phe Leu 
    210                 215                 220                 


Glu Ala Leu Pro Gln Glu Ser Trp Gln Asn Lys His Ala Gly Ser Asn 
225                 230                 235                 240 


Glu Gly Ser Cys Val Gln Asp Glu Ser Glu Pro Gln Arg Pro Leu Cys 
                245                 250                 255     


His Cys Gln Gln Pro Gln Leu Tyr Leu Pro Glu Gly Gln Xaa Arg Asn 
            260                 265                 270         


Pro 
    


<210> 5040
<211> 455
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<400> 5040
Met Lys Ser Gln Gly Gln His Trp Tyr Ser Ser Ser Asp Lys Asn Cys 
1               5                   10                  15      


Lys Val Ser Phe Arg Glu Lys Leu Leu Ile Ile Asp Ser Asn Leu Gly 
            20                  25                  30          


Val Gln Asp Val Glu Asn Leu Lys Phe Leu Cys Ile Gly Leu Val Pro 
        35                  40                  45              


Asn Lys Lys Leu Glu Lys Ser Ser Ser Ala Ser Asp Val Phe Glu His 
    50                  55                  60                  


Leu Leu Ala Glu Asp Leu Leu Ser Glu Glu Asp Pro Phe Phe Leu Ala 
65                  70                  75                  80  


Glu Leu Leu Tyr Ile Ile Arg Gln Lys Lys Leu Leu Gln His Leu Asn 
                85                  90                  95      


Cys Xaa Lys Glu Glu Val Glu Arg Leu Leu Pro Xaa Arg Gln Arg Val 
            100                 105                 110         


Ser Leu Phe Arg Asn Leu Leu Tyr Glu Leu Ser Glu Gly Ile Asp Ser 
        115                 120                 125             


Glu Asn Leu Lys Asp Met Ile Phe Leu Leu Lys Asp Ser Leu Pro Lys 
    130                 135                 140                 


Xaa Glu Met Xaa Ser Leu Ser Phe Leu Ala Phe Leu Glu Lys Gln Gly 
145                 150                 155                 160 


Lys Ile Asp Glu Asp Asn Leu Xaa Cys Leu Glu Asp Leu Cys Lys Xaa 
                165                 170                 175     


Val Val Pro Lys Leu Leu Arg Asn Ile Glu Lys Tyr Lys Arg Glu Lys 
            180                 185                 190         


Ala Ile Gln Ile Val Xaa Pro Pro Val Asp Lys Glu Ala Glu Ser Tyr 
        195                 200                 205             


Gln Gly Glu Glu Glu Leu Val Ser Gln Xaa Asp Val Lys Xaa Phe Leu 
    210                 215                 220                 


Glu Ala Leu Pro Gln Glu Ser Trp Gln Asn Lys His Ala Gly Ser Asn 
225                 230                 235                 240 


Glu Ile Leu Ser His Val Phe Gln Trp Leu Gly Phe Xaa Val His Ile 
                245                 250                 255     


His Asn Asn Val Xaa Lys Val Glu Met Glu Met Val Leu Gln Lys Gln 
            260                 265                 270         


Lys Cys Asn Pro Ala His Ala Asp Gly Asp Cys Phe Val Phe Cys Ile 
        275                 280                 285             


Leu Xaa His Gly Arg Phe Gly Ala Val Tyr Ser Ser Asp Glu Ala Leu 
    290                 295                 300                 


Ile Pro Ile Arg Glu Ile Met Ser His Phe Xaa Ala Leu Gln Cys Pro 
305                 310                 315                 320 


Arg Leu Ala Glu Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gln Gly 
                325                 330                 335     


Glu Glu Ile Gln Pro Ser Val Ser Ile Glu Ala Asp Ala Leu Asn Pro 
            340                 345                 350         


Glu Gln Ala Pro Xaa Ser Leu Gln Asp Ser Ile Pro Ala Glu Ala Asp 
        355                 360                 365             


Phe Leu Leu Gly Leu Ala Xaa Val Pro Gly Tyr Val Ser Phe Arg His 
    370                 375                 380                 


Val Glu Glu Gly Ser Trp Tyr Ile Gln Ser Leu Cys Asn His Leu Lys 
385                 390                 395                 400 


Lys Leu Val Pro Arg His Glu Asp Ile Leu Ser Ile Leu Xaa Ala Val 
                405                 410                 415     


Asn Asp Asp Val Ser Arg Arg Val Asp Lys Gln Gly Xaa Lys Lys Gln 
            420                 425                 430         


Met Pro Gln Pro Ala Phe Xaa Leu Arg Lys Lys Leu Val Phe Pro Val 
        435                 440                 445             


Pro Leu Asp Ala Leu Ser Leu 
    450                 455 


<210> 5041
<211> 521
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<400> 5041
Met Lys Ser Gln Gly Gln His Trp Tyr Ser Ser Ser Asp Lys Asn Cys 
1               5                   10                  15      


Lys Val Ser Phe Arg Glu Lys Leu Leu Ile Ile Asp Ser Asn Leu Gly 
            20                  25                  30          


Val Gln Asp Val Glu Asn Leu Lys Phe Leu Cys Ile Gly Leu Val Pro 
        35                  40                  45              


Asn Lys Lys Leu Glu Lys Ser Ser Ser Ala Ser Asp Val Phe Glu His 
    50                  55                  60                  


Leu Leu Ala Glu Asp Leu Leu Ser Glu Glu Asp Pro Phe Phe Leu Ala 
65                  70                  75                  80  


Glu Leu Leu Tyr Ile Ile Arg Gln Lys Lys Leu Leu Gln His Leu Asn 
                85                  90                  95      


Cys Xaa Lys Glu Glu Val Glu Arg Leu Leu Pro Xaa Arg Gln Arg Val 
            100                 105                 110         


Ser Leu Phe Arg Asn Leu Leu Tyr Glu Leu Ser Glu Gly Ile Asp Ser 
        115                 120                 125             


Glu Asn Leu Lys Asp Met Ile Phe Leu Leu Lys Asp Ser Leu Pro Lys 
    130                 135                 140                 


Xaa Glu Met Xaa Ser Leu Ser Phe Leu Ala Phe Leu Glu Lys Gln Gly 
145                 150                 155                 160 


Lys Ile Asp Glu Asp Asn Leu Xaa Cys Leu Glu Asp Leu Cys Lys Xaa 
                165                 170                 175     


Val Val Pro Lys Leu Leu Arg Asn Ile Glu Lys Tyr Lys Arg Glu Lys 
            180                 185                 190         


Ala Ile Gln Ile Val Xaa Pro Pro Val Asp Lys Glu Ala Glu Ser Tyr 
        195                 200                 205             


Gln Gly Glu Glu Glu Leu Val Ser Gln Xaa Asp Val Lys Xaa Phe Leu 
    210                 215                 220                 


Glu Ala Leu Pro Gln Glu Ser Trp Gln Asn Lys His Ala Gly Ser Asn 
225                 230                 235                 240 


Gly Asn Arg Ala Xaa Asn Gly Ala Pro Ser Leu Val Ser Arg Gly Met 
                245                 250                 255     


Gln Gly Ala Ser Ala Asn Xaa Leu Asn Ser Glu Xaa Ser Xaa Lys Arg 
            260                 265                 270         


Ala Ala Val Tyr Arg Met Asn Arg Asn His Arg Gly Leu Cys Val Ile 
        275                 280                 285             


Val Asn Asn His Ser Phe Xaa Ser Leu Lys Asp Arg Gln Gly Xaa His 
    290                 295                 300                 


Lys Asp Ala Glu Ile Leu Ser His Val Phe Gln Trp Leu Gly Phe Xaa 
305                 310                 315                 320 


Val His Ile His Asn Asn Val Xaa Lys Val Glu Met Glu Met Val Leu 
                325                 330                 335     


Gln Lys Gln Lys Cys Asn Pro Ala His Ala Asp Gly Asp Cys Phe Val 
            340                 345                 350         


Phe Cys Ile Leu Xaa His Gly Arg Phe Gly Ala Val Tyr Ser Ser Asp 
        355                 360                 365             


Glu Ala Leu Ile Pro Ile Arg Glu Ile Met Ser His Phe Xaa Ala Leu 
    370                 375                 380                 


Gln Cys Pro Arg Leu Ala Glu Lys Pro Lys Leu Phe Phe Ile Gln Ala 
385                 390                 395                 400 


Cys Gln Gly Glu Glu Ile Gln Pro Ser Val Ser Ile Glu Ala Asp Ala 
                405                 410                 415     


Leu Asn Pro Glu Gln Ala Pro Xaa Ser Leu Gln Asp Ser Ile Pro Ala 
            420                 425                 430         


Glu Ala Asp Phe Leu Leu Gly Leu Ala Xaa Val Pro Gly Tyr Val Ser 
        435                 440                 445             


Phe Arg His Val Glu Glu Gly Ser Trp Tyr Ile Gln Ser Leu Cys Asn 
    450                 455                 460                 


His Leu Lys Lys Leu Val Pro Arg Met Leu Lys Phe Leu Glu Lys Xaa 
465                 470                 475                 480 


Met Glu Ile Arg Gly Arg Lys Arg Xaa Val Trp Gly Ala Lys Gln Ile 
                485                 490                 495     


Ser Ala Xaa Ser Leu Pro Xaa Ala Ile Ser Ala Gln Xaa Pro Arg Pro 
            500                 505                 510         


Pro Met Arg Arg Trp Ser Ser Val Ser 
        515                 520     


<210> 5042
<211> 522
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<400> 5042
Met Lys Ser Gln Gly Gln His Trp Tyr Ser Ser Ser Asp Lys Asn Cys 
1               5                   10                  15      


Lys Val Ser Phe Arg Glu Lys Leu Leu Ile Ile Asp Ser Asn Leu Gly 
            20                  25                  30          


Val Gln Asp Val Glu Asn Leu Lys Phe Leu Cys Ile Gly Leu Val Pro 
        35                  40                  45              


Asn Lys Lys Leu Glu Lys Ser Ser Ser Ala Ser Asp Val Phe Glu His 
    50                  55                  60                  


Leu Leu Ala Glu Asp Leu Leu Ser Glu Glu Asp Pro Phe Phe Leu Ala 
65                  70                  75                  80  


Glu Leu Leu Tyr Ile Ile Arg Gln Lys Lys Leu Leu Gln His Leu Asn 
                85                  90                  95      


Cys Xaa Lys Glu Glu Val Glu Arg Leu Leu Pro Xaa Arg Gln Arg Val 
            100                 105                 110         


Ser Leu Phe Arg Asn Leu Leu Tyr Glu Leu Ser Glu Gly Ile Asp Ser 
        115                 120                 125             


Glu Asn Leu Lys Asp Met Ile Phe Leu Leu Lys Asp Ser Leu Pro Lys 
    130                 135                 140                 


Xaa Glu Met Xaa Ser Leu Ser Phe Leu Ala Phe Leu Glu Lys Gln Gly 
145                 150                 155                 160 


Lys Ile Asp Glu Asp Asn Leu Xaa Cys Leu Glu Asp Leu Cys Lys Xaa 
                165                 170                 175     


Val Val Pro Lys Leu Leu Arg Asn Ile Glu Lys Tyr Lys Arg Glu Lys 
            180                 185                 190         


Ala Ile Gln Ile Val Xaa Pro Pro Val Asp Lys Glu Ala Glu Ser Tyr 
        195                 200                 205             


Gln Gly Glu Glu Glu Leu Val Ser Gln Xaa Asp Val Lys Xaa Phe Leu 
    210                 215                 220                 


Glu Ala Leu Pro Gln Glu Ser Trp Gln Asn Lys His Ala Gly Ser Asn 
225                 230                 235                 240 


Gly Asn Arg Ala Xaa Asn Gly Ala Pro Ser Leu Val Ser Arg Gly Met 
                245                 250                 255     


Gln Gly Ala Ser Ala Asn Xaa Leu Asn Ser Glu Xaa Ser Xaa Lys Arg 
            260                 265                 270         


Ala Ala Val Tyr Arg Met Asn Arg Asn His Arg Gly Leu Cys Val Ile 
        275                 280                 285             


Val Asn Asn His Ser Phe Xaa Ser Leu Lys Asp Arg Gln Gly Xaa His 
    290                 295                 300                 


Lys Asp Ala Glu Ile Leu Ser His Val Phe Gln Trp Leu Gly Phe Xaa 
305                 310                 315                 320 


Val His Ile His Asn Asn Val Xaa Lys Val Glu Met Glu Met Val Leu 
                325                 330                 335     


Gln Lys Gln Lys Cys Asn Pro Ala His Ala Asp Gly Asp Cys Phe Val 
            340                 345                 350         


Phe Cys Ile Leu Xaa His Gly Arg Phe Gly Ala Val Tyr Ser Ser Asp 
        355                 360                 365             


Glu Ala Leu Ile Pro Ile Arg Glu Ile Met Ser His Phe Xaa Ala Leu 
    370                 375                 380                 


Gln Cys Pro Arg Leu Ala Glu Lys Pro Lys Leu Phe Phe Ile Gln Ala 
385                 390                 395                 400 


Cys Gln Gly Glu Glu Ile Gln Pro Ser Val Ser Ile Glu Ala Asp Ala 
                405                 410                 415     


Leu Asn Pro Glu Gln Ala Pro Xaa Ser Leu Gln Asp Ser Ile Pro Ala 
            420                 425                 430         


Glu Ala Asp Phe Leu Leu Gly Leu Ala Xaa Val Pro Gly Tyr Val Ser 
        435                 440                 445             


Phe Arg His Val Glu Glu Gly Ser Trp Tyr Ile Gln Ser Leu Cys Asn 
    450                 455                 460                 


His Leu Lys Lys Leu Val Pro Arg His Glu Asp Ile Leu Ser Ile Leu 
465                 470                 475                 480 


Xaa Ala Val Asn Asp Asp Val Ser Arg Arg Val Asp Lys Gln Gly Xaa 
                485                 490                 495     


Lys Lys Gln Met Pro Gln Pro Ala Phe Xaa Leu Arg Lys Lys Leu Val 
            500                 505                 510         


Phe Pro Val Pro Leu Asp Ala Leu Ser Leu 
        515                 520         


<210> 5043
<211> 478
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<400> 5043
Met Lys Ser Gln Gly Gln His Trp Tyr Ser Ser Ser Asp Lys Asn Cys 
1               5                   10                  15      


Lys Val Ser Phe Arg Glu Lys Leu Leu Ile Ile Asp Ser Asn Leu Gly 
            20                  25                  30          


Val Gln Asp Val Glu Asn Leu Lys Phe Leu Cys Ile Gly Leu Val Pro 
        35                  40                  45              


Asn Lys Lys Leu Glu Lys Ser Ser Ser Ala Ser Asp Val Phe Glu His 
    50                  55                  60                  


Leu Leu Ala Glu Asp Leu Leu Ser Glu Glu Asp Pro Phe Phe Leu Ala 
65                  70                  75                  80  


Glu Leu Leu Tyr Ile Ile Arg Gln Lys Lys Leu Leu Gln His Leu Asn 
                85                  90                  95      


Cys Xaa Lys Glu Glu Val Glu Arg Leu Leu Pro Xaa Arg Gln Arg Val 
            100                 105                 110         


Ser Leu Phe Arg Asn Leu Leu Tyr Glu Leu Ser Glu Gly Ile Asp Ser 
        115                 120                 125             


Glu Asn Leu Lys Asp Met Ile Phe Leu Leu Lys Asp Ser Leu Pro Lys 
    130                 135                 140                 


Xaa Glu Met Xaa Ser Leu Ser Phe Leu Ala Phe Leu Glu Lys Gln Gly 
145                 150                 155                 160 


Lys Ile Asp Glu Asp Asn Leu Xaa Cys Leu Glu Asp Leu Cys Lys Xaa 
                165                 170                 175     


Val Val Pro Lys Leu Leu Arg Asn Ile Glu Lys Tyr Lys Arg Glu Lys 
            180                 185                 190         


Ala Ile Gln Ile Val Xaa Pro Pro Val Asp Lys Glu Ala Glu Ser Tyr 
        195                 200                 205             


Gln Gly Glu Glu Glu Leu Val Ser Gln Xaa Asp Val Lys Xaa Phe Leu 
    210                 215                 220                 


Glu Ala Leu Pro Arg Ala Ala Val Tyr Arg Met Asn Arg Asn His Arg 
225                 230                 235                 240 


Gly Leu Cys Val Ile Val Asn Asn His Ser Phe Xaa Ser Leu Lys Asp 
                245                 250                 255     


Arg Gln Gly Xaa His Lys Asp Ala Glu Ile Leu Ser His Val Phe Gln 
            260                 265                 270         


Trp Leu Gly Phe Xaa Val His Ile His Asn Asn Val Xaa Lys Val Glu 
        275                 280                 285             


Met Glu Met Val Leu Gln Lys Gln Lys Cys Asn Pro Ala His Ala Asp 
    290                 295                 300                 


Gly Asp Cys Phe Val Phe Cys Ile Leu Xaa His Gly Arg Phe Gly Ala 
305                 310                 315                 320 


Val Tyr Ser Ser Asp Glu Ala Leu Ile Pro Ile Arg Glu Ile Met Ser 
                325                 330                 335     


His Phe Xaa Ala Leu Gln Cys Pro Arg Leu Ala Glu Lys Pro Lys Leu 
            340                 345                 350         


Phe Phe Ile Gln Ala Cys Gln Gly Glu Glu Ile Gln Pro Ser Val Ser 
        355                 360                 365             


Ile Glu Ala Asp Ala Leu Asn Pro Glu Gln Ala Pro Xaa Ser Leu Gln 
    370                 375                 380                 


Asp Ser Ile Pro Ala Glu Ala Asp Phe Leu Leu Gly Leu Ala Xaa Val 
385                 390                 395                 400 


Pro Gly Tyr Val Ser Phe Arg His Val Glu Glu Gly Ser Trp Tyr Ile 
                405                 410                 415     


Gln Ser Leu Cys Asn His Leu Lys Lys Leu Val Pro Arg Met Leu Lys 
            420                 425                 430         


Phe Leu Glu Lys Xaa Met Glu Ile Arg Gly Arg Lys Arg Xaa Val Trp 
        435                 440                 445             


Gly Ala Lys Gln Ile Ser Ala Xaa Ser Leu Pro Xaa Ala Ile Ser Ala 
    450                 455                 460                 


Gln Xaa Pro Arg Pro Pro Met Arg Arg Trp Ser Ser Val Ser 
465                 470                 475             


<210> 5044
<211> 479
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<400> 5044
Met Lys Ser Gln Gly Gln His Trp Tyr Ser Ser Ser Asp Lys Asn Cys 
1               5                   10                  15      


Lys Val Ser Phe Arg Glu Lys Leu Leu Ile Ile Asp Ser Asn Leu Gly 
            20                  25                  30          


Val Gln Asp Val Glu Asn Leu Lys Phe Leu Cys Ile Gly Leu Val Pro 
        35                  40                  45              


Asn Lys Lys Leu Glu Lys Ser Ser Ser Ala Ser Asp Val Phe Glu His 
    50                  55                  60                  


Leu Leu Ala Glu Asp Leu Leu Ser Glu Glu Asp Pro Phe Phe Leu Ala 
65                  70                  75                  80  


Glu Leu Leu Tyr Ile Ile Arg Gln Lys Lys Leu Leu Gln His Leu Asn 
                85                  90                  95      


Cys Xaa Lys Glu Glu Val Glu Arg Leu Leu Pro Xaa Arg Gln Arg Val 
            100                 105                 110         


Ser Leu Phe Arg Asn Leu Leu Tyr Glu Leu Ser Glu Gly Ile Asp Ser 
        115                 120                 125             


Glu Asn Leu Lys Asp Met Ile Phe Leu Leu Lys Asp Ser Leu Pro Lys 
    130                 135                 140                 


Xaa Glu Met Xaa Ser Leu Ser Phe Leu Ala Phe Leu Glu Lys Gln Gly 
145                 150                 155                 160 


Lys Ile Asp Glu Asp Asn Leu Xaa Cys Leu Glu Asp Leu Cys Lys Xaa 
                165                 170                 175     


Val Val Pro Lys Leu Leu Arg Asn Ile Glu Lys Tyr Lys Arg Glu Lys 
            180                 185                 190         


Ala Ile Gln Ile Val Xaa Pro Pro Val Asp Lys Glu Ala Glu Ser Tyr 
        195                 200                 205             


Gln Gly Glu Glu Glu Leu Val Ser Gln Xaa Asp Val Lys Xaa Phe Leu 
    210                 215                 220                 


Glu Ala Leu Pro Arg Ala Ala Val Tyr Arg Met Asn Arg Asn His Arg 
225                 230                 235                 240 


Gly Leu Cys Val Ile Val Asn Asn His Ser Phe Xaa Ser Leu Lys Asp 
                245                 250                 255     


Arg Gln Gly Xaa His Lys Asp Ala Glu Ile Leu Ser His Val Phe Gln 
            260                 265                 270         


Trp Leu Gly Phe Xaa Val His Ile His Asn Asn Val Xaa Lys Val Glu 
        275                 280                 285             


Met Glu Met Val Leu Gln Lys Gln Lys Cys Asn Pro Ala His Ala Asp 
    290                 295                 300                 


Gly Asp Cys Phe Val Phe Cys Ile Leu Xaa His Gly Arg Phe Gly Ala 
305                 310                 315                 320 


Val Tyr Ser Ser Asp Glu Ala Leu Ile Pro Ile Arg Glu Ile Met Ser 
                325                 330                 335     


His Phe Xaa Ala Leu Gln Cys Pro Arg Leu Ala Glu Lys Pro Lys Leu 
            340                 345                 350         


Phe Phe Ile Gln Ala Cys Gln Gly Glu Glu Ile Gln Pro Ser Val Ser 
        355                 360                 365             


Ile Glu Ala Asp Ala Leu Asn Pro Glu Gln Ala Pro Xaa Ser Leu Gln 
    370                 375                 380                 


Asp Ser Ile Pro Ala Glu Ala Asp Phe Leu Leu Gly Leu Ala Xaa Val 
385                 390                 395                 400 


Pro Gly Tyr Val Ser Phe Arg His Val Glu Glu Gly Ser Trp Tyr Ile 
                405                 410                 415     


Gln Ser Leu Cys Asn His Leu Lys Lys Leu Val Pro Arg His Glu Asp 
            420                 425                 430         


Ile Leu Ser Ile Leu Xaa Ala Val Asn Asp Asp Val Ser Arg Arg Val 
        435                 440                 445             


Asp Lys Gln Gly Xaa Lys Lys Gln Met Pro Gln Pro Ala Phe Xaa Leu 
    450                 455                 460                 


Arg Lys Lys Leu Val Phe Pro Val Pro Leu Asp Ala Leu Ser Leu 
465                 470                 475                 


<210> 5045
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<400> 5045
Met Lys Ser Gln Gly Gln His Trp Tyr Ser Ser Ser Asp Lys Asn Cys 
1               5                   10                  15      


Lys Val Ser Phe Arg Glu Lys Leu Leu Ile Ile Asp Ser Asn Leu Gly 
            20                  25                  30          


Val Gln Asp Val Glu Asn Leu Lys Phe Leu Cys Ile Gly Leu Val Pro 
        35                  40                  45              


Asn Lys Lys Leu Glu Lys Ser Ser Ser Ala Ser Asp Val Phe Glu His 
    50                  55                  60                  


Leu Leu Ala Glu Asp Leu Leu Ser Glu Glu Asp Pro Phe Phe Leu Ala 
65                  70                  75                  80  


Glu Leu Leu Tyr Ile Ile Arg Gln Lys Lys Leu Leu Gln His Leu Asn 
                85                  90                  95      


Cys Xaa Lys Glu Glu Val Glu Arg Leu Leu Pro Xaa Arg Gln Arg Val 
            100                 105                 110         


Ser Leu Phe Arg Pro Pro 
        115             


<210> 5046
<211> 168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 5046
Met Ala Asp Glu Lys Pro Ser Asn Gly Val Leu Val His Met Val Lys 
1               5                   10                  15      


Leu Leu Ile Lys Xaa Phe Leu Asp Gly Ile Phe Asp Asp Leu Met Glu 
            20                  25                  30          


Asn Asn Val Leu Asn Xaa Asp Glu Ile His Leu Ile Gly Lys Cys Leu 
        35                  40                  45              


Lys Phe Val Val Ser Asn Ala Glu Asn Leu Val Asp Asp Ile Xaa Glu 
    50                  55                  60                  


Xaa Ala Gln Ile Ala Gly Lys Ile Phe Arg Glu His Leu Trp Asn Ser 
65                  70                  75                  80  


Lys Lys Gln Leu Ser Ser Ala Phe Leu Glu Ile Gln Gly Ala Gln Pro 
                85                  90                  95      


Ser Gly Lys Leu Lys Leu Cys Pro His Ala His Phe His Glu Leu Lys 
            100                 105                 110         


Xaa Lys Arg Ala Asp Glu Ile Tyr Pro Val Met Glu Lys Glu Arg Arg 
        115                 120                 125             


Xaa Cys Leu Ala Ser Xaa Ser Ala Xaa Lys Asn Ser Xaa Ile Phe Ile 
    130                 135                 140                 


Ile Glu Met Val Leu Asn Leu Xaa Phe Trp Gly Cys Glu Ile Tyr Leu 
145                 150                 155                 160 


Lys Xaa Leu Asp Xaa Gln Trp Leu 
                165             


<210> 5047
<211> 294
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<400> 5047
Met Ala Asp Glu Lys Pro Ser Asn Gly Val Leu Val His Met Val Lys 
1               5                   10                  15      


Leu Leu Ile Lys Xaa Phe Leu Asp Gly Ile Phe Asp Asp Leu Met Glu 
            20                  25                  30          


Asn Asn Val Leu Asn Xaa Asp Glu Ile His Leu Ile Gly Lys Cys Leu 
        35                  40                  45              


Lys Phe Val Val Ser Asn Ala Glu Asn Leu Val Asp Asp Ile Xaa Glu 
    50                  55                  60                  


Xaa Ala Gln Ile Ala Gly Lys Ile Phe Arg Glu His Leu Trp Asn Ser 
65                  70                  75                  80  


Lys Lys Gln Leu Ser Ser Asp Ile Ser Ser Asp Gly Glu Arg Glu Ala 
                85                  90                  95      


Asn Met Pro Gly Leu Asn Ile Arg Asn Lys Glu Phe Asn Tyr Leu His 
            100                 105                 110         


Asn Arg Asn Gly Ser Glu Leu Asp Leu Leu Gly Met Asp Leu Leu Glu 
        115                 120                 125             


Asn Leu Gly Tyr Ser Val Val Ile Lys Glu Asn Leu Xaa Ala Gln Glu 
    130                 135                 140                 


Met Glu Xaa Ala Leu Arg Gln Phe Ala Ala His Pro Glu His Gln Ser 
145                 150                 155                 160 


Ser Asp Ser Xaa Phe Leu Val Phe Met Ser His Ser Ile Leu Asn Gly 
                165                 170                 175     


Ile Cys Gly Xaa Lys His Trp Asp Gln Glu Pro Asp Val Leu His Asp 
            180                 185                 190         


Asp Xaa Ile Phe Glu Ile Phe Asn Asn Arg Asn Cys Gln Ser Leu Lys 
        195                 200                 205             


Asp Lys Pro Lys Met Val Leu Gly Leu Phe Gly Ser Pro Leu Xaa Val 
    210                 215                 220                 


Glu Lys Pro Val Gln Ile Leu Met Val Gly Ser Cys Lys Val Xaa Ser 
225                 230                 235                 240 


Val Met Met Leu Leu Gln Arg Leu Met Trp Lys Arg Xaa Ser Leu Leu 
                245                 250                 255     


Ser Asn Leu Pro His His Val Gln His Ser Phe Glu Xaa Pro Asn Ile 
            260                 265                 270         


Leu Xaa Gln Leu Pro Xaa Ile Glu Arg Leu Ser Met Xaa Arg Tyr Phe 
        275                 280                 285             


Tyr Leu Phe Pro Gly Asn 
    290                 


<210> 5048
<211> 276
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<400> 5048
Met Ala Asp Glu Lys Pro Ser Asn Gly Val Leu Val His Met Val Lys 
1               5                   10                  15      


Leu Leu Ile Lys Xaa Phe Leu Asp Gly Ile Phe Asp Asp Leu Met Glu 
            20                  25                  30          


Asn Asn Val Leu Asn Xaa Asp Glu Ile His Leu Ile Gly Lys Cys Leu 
        35                  40                  45              


Lys Phe Val Val Ser Asn Ala Glu Asn Leu Val Asp Asp Ile Xaa Glu 
    50                  55                  60                  


Xaa Ala Gln Ile Ala Gly Lys Ile Phe Arg Glu His Leu Trp Asn Ser 
65                  70                  75                  80  


Lys Lys Gln Leu Ser Ser Asp Ile Ser Ser Asp Gly Glu Arg Glu Ala 
                85                  90                  95      


Asn Met Pro Gly Leu Asn Ile Arg Asn Lys Glu Phe Asn Tyr Leu His 
            100                 105                 110         


Asn Arg Asn Gly Ser Glu Leu Asp Leu Leu Gly Met Asp Leu Leu Glu 
        115                 120                 125             


Asn Leu Gly Tyr Ser Val Val Ile Lys Glu Asn Leu Xaa Ala Gln Glu 
    130                 135                 140                 


Met Glu Xaa Ala Leu Arg Gln Phe Ala Ala His Pro Glu His Gln Ser 
145                 150                 155                 160 


Ser Asp Ser Xaa Phe Leu Val Phe Met Ser His Ser Ile Leu Asn Gly 
                165                 170                 175     


Ile Cys Gly Xaa Lys His Trp Asp Gln Glu Pro Asp Val Leu His Asp 
            180                 185                 190         


Asp Xaa Ile Phe Glu Ile Phe Asn Asn Arg Asn Cys Gln Ser Leu Lys 
        195                 200                 205             


Asp Lys Pro Lys Val Ile Ile Met Gln Ala Cys Arg Gly Asn Gly Ala 
    210                 215                 220                 


Gly Ile Val Trp Phe Xaa Xaa Asp Ser Gly Lys Ala Ser Ala Asp Xaa 
225                 230                 235                 240 


His Gly Arg Leu Leu Gln Gly Asn Ile Cys Asn Asp Ala Val Xaa Lys 
                245                 250                 255     


Ala His Val Glu Lys Asp Phe Ile Ala Phe Lys Ser Ser Xaa Pro Arg 
            260                 265                 270         


Ser Xaa Phe Ile 
        275     


<210> 5049
<211> 340
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<400> 5049
Met Ala Asp Glu Lys Pro Ser Asn Gly Val Leu Val His Met Val Lys 
1               5                   10                  15      


Leu Leu Ile Lys Xaa Phe Leu Asp Gly Ile Phe Asp Asp Leu Met Glu 
            20                  25                  30          


Asn Asn Val Leu Asn Xaa Asp Glu Ile His Leu Ile Gly Lys Cys Leu 
        35                  40                  45              


Lys Phe Val Val Ser Asn Ala Glu Asn Leu Val Asp Asp Ile Xaa Glu 
    50                  55                  60                  


Xaa Ala Gln Ile Ala Gly Lys Ile Phe Arg Glu His Leu Trp Asn Ser 
65                  70                  75                  80  


Lys Lys Gln Leu Ser Ser Asp Ile Ser Ser Asp Gly Glu Arg Glu Ala 
                85                  90                  95      


Asn Met Pro Gly Leu Asn Ile Arg Asn Lys Glu Phe Asn Tyr Leu His 
            100                 105                 110         


Asn Arg Asn Gly Ser Glu Leu Asp Leu Leu Gly Met Asp Leu Leu Glu 
        115                 120                 125             


Asn Leu Gly Tyr Ser Val Val Ile Lys Glu Asn Leu Xaa Ala Gln Glu 
    130                 135                 140                 


Met Glu Xaa Ala Leu Arg Gln Phe Ala Ala His Pro Glu His Gln Ser 
145                 150                 155                 160 


Ser Asp Ser Xaa Phe Leu Val Phe Met Ser His Ser Ile Leu Asn Gly 
                165                 170                 175     


Ile Cys Gly Xaa Lys His Trp Asp Gln Glu Pro Asp Val Leu His Asp 
            180                 185                 190         


Asp Xaa Ile Phe Glu Ile Phe Asn Asn Arg Asn Cys Gln Ser Leu Lys 
        195                 200                 205             


Asp Lys Pro Lys Val Ile Ile Met Gln Ala Cys Arg Gly Asn Gly Ala 
    210                 215                 220                 


Gly Ile Val Trp Phe Xaa Xaa Asp Ser Gly Lys Ala Ser Ala Asp Xaa 
225                 230                 235                 240 


His Gly Arg Leu Leu Gln Gly Asn Ile Cys Asn Asp Ala Val Xaa Lys 
                245                 250                 255     


Ala His Val Glu Lys Asp Phe Ile Ala Phe Lys Ser Ser Xaa Pro His 
            260                 265                 270         


Asn Val Ser Trp Arg His Glu Xaa Asn Gly Ser Val Phe Ile Ser Gln 
        275                 280                 285             


Ile Ile Tyr Tyr Phe Arg Glu Tyr Ser Trp Ser His His Leu Glu Glu 
    290                 295                 300                 


Ile Phe Gln Lys Val Gln His Ser Phe Glu Xaa Pro Asn Ile Leu Xaa 
305                 310                 315                 320 


Gln Leu Pro Xaa Ile Glu Arg Leu Ser Met Xaa Arg Tyr Phe Tyr Leu 
                325                 330                 335     


Phe Pro Gly Asn 
            340 


<210> 5050
<211> 223
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(214)
<223> Selenocysteine

<400> 5050
Met Ala Asp Glu Lys Pro Ser Asn Gly Val Leu Val His Met Val Lys 
1               5                   10                  15      


Leu Leu Ile Lys Xaa Phe Leu Asp Gly Ile Phe Asp Asp Leu Met Glu 
            20                  25                  30          


Asn Asn Val Leu Asn Xaa Asp Glu Ile His Leu Ile Gly Lys Cys Leu 
        35                  40                  45              


Lys Phe Val Val Ser Asn Ala Glu Asn Leu Val Asp Asp Ile Xaa Glu 
    50                  55                  60                  


Xaa Ala Gln Ile Ala Gly Lys Ile Phe Arg Glu His Leu Trp Asn Ser 
65                  70                  75                  80  


Lys Lys Gln Leu Ser Ser Asp Ile Ser Ser Asp Gly Glu Arg Glu Ala 
                85                  90                  95      


Asn Met Pro Gly Leu Asn Ile Arg Asn Lys Glu Phe Asn Tyr Leu His 
            100                 105                 110         


Asn Arg Asn Gly Ser Glu Leu Asp Leu Leu Gly Met Asp Leu Leu Glu 
        115                 120                 125             


Asn Leu Gly Tyr Ser Val Val Ile Lys Glu Asn Leu Xaa Ala Gln Met 
    130                 135                 140                 


Val Leu Gly Leu Phe Gly Ser Pro Leu Xaa Val Glu Lys Pro Val Gln 
145                 150                 155                 160 


Ile Leu Met Val Gly Ser Cys Lys Val Xaa Ser Val Met Met Leu Leu 
                165                 170                 175     


Gln Arg Leu Met Trp Lys Arg Xaa Ser Leu Leu Ser Asn Leu Pro His 
            180                 185                 190         


His Ile Met Phe Leu Gly Asp Met Lys Gln Met Ala Leu Ser Ser Phe 
        195                 200                 205             


Pro Lys Leu Ser Xaa Xaa Ser Glu Ser Ile Leu Gly Val Ile Ile 
    210                 215                 220             


<210> 5051
<211> 225
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<400> 5051
Met Ala Asp Glu Lys Pro Ser Asn Gly Val Leu Val His Met Val Lys 
1               5                   10                  15      


Leu Leu Ile Lys Xaa Phe Leu Asp Gly Ile Phe Asp Asp Leu Met Glu 
            20                  25                  30          


Asn Asn Val Leu Asn Xaa Asp Glu Ile His Leu Ile Gly Lys Cys Leu 
        35                  40                  45              


Lys Phe Val Val Ser Asn Ala Glu Asn Leu Val Asp Asp Ile Xaa Glu 
    50                  55                  60                  


Xaa Ala Gln Ile Ala Gly Lys Ile Phe Arg Glu His Leu Trp Asn Ser 
65                  70                  75                  80  


Lys Lys Gln Leu Ser Ser Asp Ile Ser Ser Asp Gly Glu Arg Glu Ala 
                85                  90                  95      


Asn Met Pro Gly Leu Asn Ile Arg Asn Lys Glu Phe Asn Tyr Leu His 
            100                 105                 110         


Asn Arg Asn Gly Ser Glu Leu Asp Leu Leu Gly Met Asp Leu Leu Glu 
        115                 120                 125             


Asn Leu Gly Tyr Ser Val Val Ile Lys Glu Asn Leu Xaa Ala Gln Met 
    130                 135                 140                 


Val Leu Gly Leu Phe Gly Ser Pro Leu Xaa Val Glu Lys Pro Val Gln 
145                 150                 155                 160 


Ile Leu Met Val Gly Ser Cys Lys Val Xaa Ser Val Met Met Leu Leu 
                165                 170                 175     


Gln Arg Leu Met Trp Lys Arg Xaa Ser Leu Leu Ser Asn Leu Pro His 
            180                 185                 190         


His Val Gln His Ser Phe Glu Xaa Pro Asn Ile Leu Xaa Gln Leu Pro 
        195                 200                 205             


Xaa Ile Glu Arg Leu Ser Met Xaa Arg Tyr Phe Tyr Leu Phe Pro Gly 
    210                 215                 220                 


Asn 
225 


<210> 5052
<211> 340
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<400> 5052
Met Ala Asp Glu Lys Pro Ser Asn Gly Val Leu Val His Met Val Lys 
1               5                   10                  15      


Leu Leu Ile Lys Xaa Phe Leu Asp Gly Ile Phe Asp Asp Leu Met Glu 
            20                  25                  30          


Asn Asn Val Leu Asn Xaa Asp Glu Ile His Leu Ile Gly Lys Cys Leu 
        35                  40                  45              


Lys Phe Val Val Ser Asn Ala Glu Asn Leu Val Asp Asp Ile Xaa Glu 
    50                  55                  60                  


Xaa Ala Gln Ile Ala Gly Lys Ile Phe Arg Glu His Leu Trp Asn Ser 
65                  70                  75                  80  


Lys Lys Gln Leu Ser Ser Asp Ile Ser Ser Asp Gly Glu Arg Glu Ala 
                85                  90                  95      


Asn Met Pro Gly Leu Asn Ile Arg Asn Lys Glu Phe Asn Tyr Leu His 
            100                 105                 110         


Asn Arg Asn Gly Ser Glu Leu Asp Leu Leu Gly Met Asp Leu Leu Glu 
        115                 120                 125             


Asn Leu Gly Tyr Ser Val Val Ile Lys Glu Asn Leu Xaa Ala Gln Glu 
    130                 135                 140                 


Met Glu Xaa Ala Leu Arg Gln Phe Ala Ala His Pro Glu His Gln Ser 
145                 150                 155                 160 


Ser Asp Ser Xaa Phe Leu Val Phe Met Ser His Ser Ile Leu Asn Gly 
                165                 170                 175     


Ile Cys Gly Xaa Lys His Trp Asp Gln Glu Pro Asp Val Leu His Asp 
            180                 185                 190         


Asp Xaa Ile Phe Glu Ile Phe Asn Asn Arg Asn Cys Gln Ser Leu Lys 
        195                 200                 205             


Asp Lys Pro Lys Val Ile Ile Met Gln Ala Cys Arg Gly Asn Gly Ala 
    210                 215                 220                 


Gly Ile Val Trp Phe Xaa Xaa Asp Ser Gly Lys Ala Ser Ala Asp Xaa 
225                 230                 235                 240 


His Gly Arg Leu Leu Gln Gly Asn Ile Cys Asn Asp Ala Val Xaa Lys 
                245                 250                 255     


Ala His Val Glu Lys Asp Phe Ile Ala Phe Lys Ser Ser Xaa Pro His 
            260                 265                 270         


Asn Val Ser Trp Arg His Glu Xaa Asn Gly Ser Val Phe Ile Ser Gln 
        275                 280                 285             


Ile Ile Tyr Tyr Phe Arg Glu Tyr Ser Trp Ser His His Leu Glu Glu 
    290                 295                 300                 


Ile Phe Gln Lys Val Gln His Ser Phe Glu Xaa Pro Asn Ile Leu Xaa 
305                 310                 315                 320 


Gln Leu Pro Xaa Ile Glu Arg Leu Ser Met Xaa Arg Tyr Phe Tyr Leu 
                325                 330                 335     


Phe Pro Gly Asn 
            340 


<210> 5053
<211> 256
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<400> 5053
Met Ala Asp Ile Ser Ser Asp Gly Glu Arg Glu Ala Asn Met Pro Gly 
1               5                   10                  15      


Leu Asn Ile Arg Asn Lys Glu Phe Asn Tyr Leu His Asn Arg Asn Gly 
            20                  25                  30          


Ser Glu Leu Asp Leu Leu Gly Met Asp Leu Leu Glu Asn Leu Gly Tyr 
        35                  40                  45              


Ser Val Val Ile Lys Glu Asn Leu Xaa Ala Gln Glu Met Glu Xaa Ala 
    50                  55                  60                  


Leu Arg Gln Phe Ala Ala His Pro Glu His Gln Ser Ser Asp Ser Xaa 
65                  70                  75                  80  


Phe Leu Val Phe Met Ser His Ser Ile Leu Asn Gly Ile Cys Gly Xaa 
                85                  90                  95      


Lys His Trp Asp Gln Glu Pro Asp Val Leu His Asp Asp Xaa Ile Phe 
            100                 105                 110         


Glu Ile Phe Asn Asn Arg Asn Cys Gln Ser Leu Lys Asp Lys Pro Lys 
        115                 120                 125             


Val Ile Ile Met Gln Ala Cys Arg Gly Asn Gly Ala Gly Ile Val Trp 
    130                 135                 140                 


Phe Xaa Xaa Asp Ser Gly Lys Ala Ser Ala Asp Xaa His Gly Arg Leu 
145                 150                 155                 160 


Leu Gln Gly Asn Ile Cys Asn Asp Ala Val Xaa Lys Ala His Val Glu 
                165                 170                 175     


Lys Asp Phe Ile Ala Phe Lys Ser Ser Xaa Pro His Asn Val Ser Trp 
            180                 185                 190         


Arg His Glu Xaa Asn Gly Ser Val Phe Ile Ser Gln Ile Ile Tyr Tyr 
        195                 200                 205             


Phe Arg Glu Tyr Ser Trp Ser His His Leu Glu Glu Ile Phe Gln Lys 
    210                 215                 220                 


Val Gln His Ser Phe Glu Xaa Pro Asn Ile Leu Xaa Gln Leu Pro Xaa 
225                 230                 235                 240 


Ile Glu Arg Leu Ser Met Xaa Arg Tyr Phe Tyr Leu Phe Pro Gly Asn 
                245                 250                 255     


<210> 5054
<211> 139
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(130)
<223> Selenocysteine

<400> 5054
Met Ala Asp Ile Ser Ser Asp Gly Glu Arg Glu Ala Asn Met Pro Gly 
1               5                   10                  15      


Leu Asn Ile Arg Asn Lys Glu Phe Asn Tyr Leu His Asn Arg Asn Gly 
            20                  25                  30          


Ser Glu Leu Asp Leu Leu Gly Met Asp Leu Leu Glu Asn Leu Gly Tyr 
        35                  40                  45              


Ser Val Val Ile Lys Glu Asn Leu Xaa Ala Gln Met Val Leu Gly Leu 
    50                  55                  60                  


Phe Gly Ser Pro Leu Xaa Val Glu Lys Pro Val Gln Ile Leu Met Val 
65                  70                  75                  80  


Gly Ser Cys Lys Val Xaa Ser Val Met Met Leu Leu Gln Arg Leu Met 
                85                  90                  95      


Trp Lys Arg Xaa Ser Leu Leu Ser Asn Leu Pro His His Ile Met Phe 
            100                 105                 110         


Leu Gly Asp Met Lys Gln Met Ala Leu Ser Ser Phe Pro Lys Leu Ser 
        115                 120                 125             


Xaa Xaa Ser Glu Ser Ile Leu Gly Val Ile Ile 
    130                 135                 


<210> 5055
<211> 141
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<400> 5055
Met Ala Asp Ile Ser Ser Asp Gly Glu Arg Glu Ala Asn Met Pro Gly 
1               5                   10                  15      


Leu Asn Ile Arg Asn Lys Glu Phe Asn Tyr Leu His Asn Arg Asn Gly 
            20                  25                  30          


Ser Glu Leu Asp Leu Leu Gly Met Asp Leu Leu Glu Asn Leu Gly Tyr 
        35                  40                  45              


Ser Val Val Ile Lys Glu Asn Leu Xaa Ala Gln Met Val Leu Gly Leu 
    50                  55                  60                  


Phe Gly Ser Pro Leu Xaa Val Glu Lys Pro Val Gln Ile Leu Met Val 
65                  70                  75                  80  


Gly Ser Cys Lys Val Xaa Ser Val Met Met Leu Leu Gln Arg Leu Met 
                85                  90                  95      


Trp Lys Arg Xaa Ser Leu Leu Ser Asn Leu Pro His His Val Gln His 
            100                 105                 110         


Ser Phe Glu Xaa Pro Asn Ile Leu Xaa Gln Leu Pro Xaa Ile Glu Arg 
        115                 120                 125             


Leu Ser Met Xaa Arg Tyr Phe Tyr Leu Phe Pro Gly Asn 
    130                 135                 140     


<210> 5056
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<400> 5056
Met Ala Ala Pro Ser Ala Gly Ser Trp Ser Xaa Phe Gln His Lys Glu 
1               5                   10                  15      


Leu Met Ala Ala Asp Arg Gly Arg Arg Ile Leu Gly Val Cys Gly Met 
            20                  25                  30          


His Pro His His Gln Glu Xaa Leu Lys Lys Asn Arg Val Val Leu Ala 
        35                  40                  45              


Lys Gln Leu Leu Leu Ser Glu Leu Leu Glu His Leu Leu Glu Lys Asp 
    50                  55                  60                  


Ile Ile Xaa Leu Glu Met Arg Glu Leu Ile Gln Ala Lys Val Gly Ser 
65                  70                  75                  80  


Phe Ser Gln Asn Val Glu Leu Leu Asn Leu Leu Pro Lys Arg Gly Pro 
                85                  90                  95      


Gln Ala Phe Asp Ala Phe Cys Glu Ala Leu His Ser 
            100                 105             


<210> 5057
<211> 452
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<400> 5057
Met Ala Ala Pro Ser Ala Gly Ser Trp Ser Xaa Phe Gln His Lys Glu 
1               5                   10                  15      


Leu Met Ala Ala Asp Arg Gly Arg Arg Ile Leu Gly Val Cys Gly Met 
            20                  25                  30          


His Pro His His Gln Glu Xaa Leu Lys Lys Asn Arg Val Val Leu Ala 
        35                  40                  45              


Lys Gln Leu Leu Leu Ser Glu Leu Leu Glu His Leu Leu Glu Lys Asp 
    50                  55                  60                  


Ile Ile Xaa Leu Glu Met Arg Glu Leu Ile Gln Ala Lys Val Gly Ser 
65                  70                  75                  80  


Phe Ser Gln Asn Val Glu Leu Leu Asn Leu Leu Pro Lys Arg Gly Pro 
                85                  90                  95      


Gln Ala Phe Asp Ala Phe Cys Glu Ala Leu Arg Glu Xaa Lys Gln Gly 
            100                 105                 110         


His Leu Glu Asp Met Leu Leu Xaa Xaa Leu Ser Gly Leu Gln His Val 
        115                 120                 125             


Leu Pro Pro Leu Ser Cys Asp Tyr Asp Leu Ser Leu Pro Phe Pro Val 
    130                 135                 140                 


Cys Glu Ser Cys Pro Leu Tyr Lys Lys Leu Arg Leu Ser Xaa Asp Xaa 
145                 150                 155                 160 


Val Glu His Ser Leu Asp Asn Lys Asp Gly Pro Val Cys Leu Gln Val 
                165                 170                 175     


Lys Pro Cys Xaa Pro Glu Phe Tyr Gln Xaa His Phe Gln Leu Ala Tyr 
            180                 185                 190         


Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val 
        195                 200                 205             


His Phe Xaa Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp Val 
    210                 215                 220                 


Asp His Ser Xaa Leu Val Xaa Leu Phe Lys Leu Leu Gly Tyr Asp Val 
225                 230                 235                 240 


His Val Leu Cys Asp Gln Xaa Ala Gln Glu Met Gln Glu Lys Leu Gln 
                245                 250                 255     


Asn Phe Ala Gln Leu Pro Ala His Arg Val Xaa Asp Ser Cys Ile Val 
            260                 265                 270         


Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly 
        275                 280                 285             


Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn 
    290                 295                 300                 


Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys 
305                 310                 315                 320 


Arg Gly Asp Glu Xaa Asp Arg Gly Val Asp Gln Gln Asp Gly Lys Asn 
                325                 330                 335     


His Ala Gly Ser Pro Gly Cys Glu Glu Ser Asp Ala Gly Lys Glu Lys 
            340                 345                 350         


Leu Pro Lys Met Arg Leu Pro Xaa Arg Ser Asp Met Ile Cys Gly Tyr 
        355                 360                 365             


Ala Cys Leu Lys Gly Xaa Ala Ala Met Arg Asn Xaa Lys Arg Gly Ser 
    370                 375                 380                 


Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe Ser Glu Arg Ala Cys Asp 
385                 390                 395                 400 


Met His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu Ile Lys Asp 
                405                 410                 415     


Arg Glu Gly Tyr Ala Pro Gly Xaa Glu Phe His Arg Cys Lys Glu Met 
            420                 425                 430         


Ser Glu Tyr Cys Ser Xaa Leu Cys Arg His Leu Tyr Leu Phe Pro Gly 
        435                 440                 445             


His Pro Pro Xaa 
    450         


<210> 5058
<211> 171
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 5058
Met Ala Ala Pro Ser Ala Gly Ser Trp Ser Xaa Phe Gln His Lys Glu 
1               5                   10                  15      


Leu Met Ala Ala Asp Arg Gly Arg Arg Ile Leu Gly Val Cys Gly Met 
            20                  25                  30          


His Pro His His Gln Glu Xaa Leu Lys Lys Asn Arg Val Val Leu Ala 
        35                  40                  45              


Lys Gln Leu Leu Leu Ser Glu Leu Leu Glu His Leu Leu Glu Lys Asp 
    50                  55                  60                  


Ile Ile Xaa Leu Glu Met Arg Glu Leu Ile Gln Ala Lys Val Gly Ser 
65                  70                  75                  80  


Phe Ser Gln Asn Val Glu Leu Leu Asn Leu Leu Pro Lys Arg Gly Pro 
                85                  90                  95      


Gln Ala Phe Asp Ala Phe Cys Glu Ala Leu Arg Glu Xaa Lys Gln Gly 
            100                 105                 110         


His Leu Glu Asp Met Leu Leu Xaa Xaa Leu Ser Gly Leu Gln His Val 
        115                 120                 125             


Leu Pro Pro Leu Ser Cys Asp Tyr Asp Leu Ser Leu Pro Phe Pro Val 
    130                 135                 140                 


Cys Glu Ser Cys Pro Leu Tyr Lys Lys Leu Arg Leu Ser Xaa Glu Ile 
145                 150                 155                 160 


Gly Ser Cys Ser Val Xaa Gln Ala Gly Met Gln 
                165                 170     


<210> 5059
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 5059
Met Glu Asn Xaa Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Xaa Gly Met Xaa Ser Arg 
    50                  55                  60                  


Ser Gly Xaa Asp Val Asp Ala Ala Asn Leu Arg Glu Xaa Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Xaa Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val 
        115         


<210> 5060
<211> 277
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<400> 5060
Met Glu Asn Xaa Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Xaa Gly Met Xaa Ser Arg 
    50                  55                  60                  


Ser Gly Xaa Asp Val Asp Ala Ala Asn Leu Arg Glu Xaa Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Xaa Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
        115                 120                 125             


Gly Xaa Asn Gly Pro Val Asp Leu Lys Lys Ile Xaa Asn Phe Phe Arg 
    130                 135                 140                 


Gly Asp Arg Cys Arg Ser Leu Xaa Gly Lys Pro Lys Leu Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Xaa Glu Leu Asp Cys Gly Ile Glu Xaa Asp Ser 
                165                 170                 175     


Gly Val Asp Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp 
            180                 185                 190         


Phe Leu Tyr Ala Tyr Ser Xaa Ala Pro Gly Tyr Tyr Ser Trp Arg Asn 
        195                 200                 205             


Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys 
    210                 215                 220                 


Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Xaa Arg Val Asn 
225                 230                 235                 240 


Arg Lys Val Ala Xaa Glu Phe Glu Ser Phe Ser Phe Asp Ala Xaa Phe 
                245                 250                 255     


His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Xaa Lys Glu 
            260                 265                 270         


Leu Tyr Phe Tyr His 
        275         


<210> 5061
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<400> 5061
Met Glu Asn Xaa Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Xaa Gly Met Xaa Ser Arg 
    50                  55                  60                  


Ser Gly Xaa Asp Val Asp Ala Ala Asn Leu Arg Glu Xaa Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Xaa Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
        115                 120                 125             


Gly Xaa Asn Gly Pro Val Asp Leu Lys Lys Ile Xaa Asn Phe Phe Arg 
    130                 135                 140                 


Gly Asp Arg Cys Arg Ser Leu Xaa Gly Lys Pro Lys Leu Phe Ile Ile 
145                 150                 155                 160 


Gln Val Ile Ile Leu Gly Glu Ile Gln Arg Met Ala Pro Gly Ser Ser 
                165                 170                 175     


Ser Arg Phe Val Pro Cys 
            180         


<210> 5062
<211> 321
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<400> 5062
Met Ala Asp Ser Met Gln Glu Lys Gln Arg Met Ala Gly Gln Met Leu 
1               5                   10                  15      


Leu Gln Xaa Phe Phe Asn Ile Asp Gln Ile Ser Pro Asn Lys Lys Ala 
            20                  25                  30          


His Pro Asn Met Glu Ala Gly Pro Pro Glu Ser Gly Glu Ser Xaa Asp 
        35                  40                  45              


Ala Leu Lys Leu Cys Pro His Glu Glu Phe Leu Arg Leu Cys Lys Glu 
    50                  55                  60                  


Arg Ala Glu Glu Ile Tyr Pro Ile Lys Glu Arg Asn Asn Arg Xaa Arg 
65                  70                  75                  80  


Leu Ala Leu Ile Ile Cys Asn Xaa Glu Phe Asp His Leu Pro Pro Arg 
                85                  90                  95      


Asn Gly Ala Asp Phe Asp Ile Xaa Gly Met Lys Glu Leu Leu Glu Gly 
            100                 105                 110         


Leu Asp Tyr Ser Val Asp Val Glu Glu Asn Leu Xaa Ala Arg Asp Met 
        115                 120                 125             


Glu Ser Ala Leu Arg Ala Phe Ala Xaa Arg Pro Glu His Lys Ser Ser 
    130                 135                 140                 


Asp Ser Xaa Phe Leu Val Leu Met Ser His Gly Ile Leu Glu Gly Ile 
145                 150                 155                 160 


Cys Gly Xaa Val His Asp Glu Lys Lys Pro Asp Val Leu Leu Tyr Asp 
                165                 170                 175     


Xaa Ile Phe Gln Ile Phe Asn Asn Arg Asn Cys Leu Ser Leu Lys Asp 
            180                 185                 190         


Lys Pro Lys Val Ile Ile Val Gln Ala Cys Arg Gly Ala Asn Arg Gly 
        195                 200                 205             


Glu Leu Trp Val Arg Asp Ser Pro Ala Ser Leu Glu Val Ala Ser Ser 
    210                 215                 220                 


Gln Ser Ser Glu Asn Leu Glu Glu Asp Ala Val Tyr Lys Xaa His Val 
225                 230                 235                 240 


Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser Xaa Pro His Asn Val Ser 
                245                 250                 255     


Trp Arg Asp Ser Xaa Met Gly Ser Ile Phe Ile Xaa Gln Leu Ile Xaa 
            260                 265                 270         


Cys Phe Gln Lys Tyr Ser Trp Cys Cys His Leu Glu Glu Val Phe Arg 
        275                 280                 285             


Lys Val Gln Gln Ser Phe Glu Xaa Pro Arg Ala Lys Ala Gln Met Pro 
    290                 295                 300                 


Xaa Ile Glu Arg Leu Ser Met Xaa Arg Tyr Phe Tyr Leu Phe Pro Gly 
305                 310                 315                 320 


Asn 
    


<210> 5063
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<400> 5063
Met Ala Glu Gly Asn His Arg Lys Lys Pro Leu Lys Val Leu Glu Ser 
1               5                   10                  15      


Leu Gly Lys Asp Phe Leu Xaa Gly Val Leu Asp Asn Leu Val Glu Gln 
            20                  25                  30          


Asn Val Leu Asn Trp Lys Glu Glu Glu Lys Lys Lys Tyr Tyr Asp Ala 
        35                  40                  45              


Lys Xaa Glu Asp Lys Val Arg Val Met Ala Asp Ser Met Gln Glu Lys 
    50                  55                  60                  


Gln Arg Met Ala Gly Gln Met Leu Leu Gln Xaa Phe Phe Asn Ile Asp 
65                  70                  75                  80  


Gln Ile Ser Pro Asn Lys Lys Ala His Pro Asn Met Glu Ala Gly Pro 
                85                  90                  95      


Pro Glu Ser Gly Glu Ser Xaa Asp Ala Leu Lys Leu Cys Pro His Glu 
            100                 105                 110         


Glu Phe Leu Arg Leu Cys Lys Glu Arg Ala Glu Glu Ile Tyr Pro Ile 
        115                 120                 125             


Lys Glu Arg Asn Asn Arg Xaa Arg Leu Ala Leu Ile Ile Cys Asn Xaa 
    130                 135                 140                 


Glu Phe Asp 
145         


<210> 5064
<211> 377
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<400> 5064
Met Ala Glu Gly Asn His Arg Lys Lys Pro Leu Lys Val Leu Glu Ser 
1               5                   10                  15      


Leu Gly Lys Asp Phe Leu Xaa Gly Val Leu Asp Asn Leu Val Glu Gln 
            20                  25                  30          


Asn Val Leu Asn Trp Lys Glu Glu Glu Lys Lys Lys Tyr Tyr Asp Ala 
        35                  40                  45              


Lys Xaa Glu Asp Lys Val Arg Val Met Ala Asp Ser Met Gln Glu Lys 
    50                  55                  60                  


Gln Arg Met Ala Gly Gln Met Leu Leu Gln Xaa Phe Phe Asn Ile Asp 
65                  70                  75                  80  


Gln Ile Ser Pro Asn Lys Lys Ala His Pro Asn Met Glu Ala Gly Pro 
                85                  90                  95      


Pro Glu Ser Gly Glu Ser Xaa Asp Ala Leu Lys Leu Cys Pro His Glu 
            100                 105                 110         


Glu Phe Leu Arg Leu Cys Lys Glu Arg Ala Glu Glu Ile Tyr Pro Ile 
        115                 120                 125             


Lys Glu Arg Asn Asn Arg Xaa Arg Leu Ala Leu Ile Ile Cys Asn Xaa 
    130                 135                 140                 


Glu Phe Asp His Leu Pro Pro Arg Asn Gly Ala Asp Phe Asp Ile Xaa 
145                 150                 155                 160 


Gly Met Lys Glu Leu Leu Glu Gly Leu Asp Tyr Ser Val Asp Val Glu 
                165                 170                 175     


Glu Asn Leu Xaa Ala Arg Asp Met Glu Ser Ala Leu Arg Ala Phe Ala 
            180                 185                 190         


Xaa Arg Pro Glu His Lys Ser Ser Asp Ser Xaa Phe Leu Val Leu Met 
        195                 200                 205             


Ser His Gly Ile Leu Glu Gly Ile Cys Gly Xaa Val His Asp Glu Lys 
    210                 215                 220                 


Lys Pro Asp Val Leu Leu Tyr Asp Xaa Ile Phe Gln Ile Phe Asn Asn 
225                 230                 235                 240 


Arg Asn Cys Leu Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Val Gln 
                245                 250                 255     


Ala Cys Arg Gly Ala Asn Arg Gly Glu Leu Trp Val Arg Asp Ser Pro 
            260                 265                 270         


Ala Ser Leu Glu Val Ala Ser Ser Gln Ser Ser Glu Asn Leu Glu Glu 
        275                 280                 285             


Asp Ala Val Tyr Lys Xaa His Val Glu Lys Asp Phe Ile Ala Phe Cys 
    290                 295                 300                 


Ser Ser Xaa Pro His Asn Val Ser Trp Arg Asp Ser Xaa Met Gly Ser 
305                 310                 315                 320 


Ile Phe Ile Xaa Gln Leu Ile Xaa Cys Phe Gln Lys Tyr Ser Trp Cys 
                325                 330                 335     


Cys His Leu Glu Glu Val Phe Arg Lys Val Gln Gln Ser Phe Glu Xaa 
            340                 345                 350         


Pro Arg Ala Lys Ala Gln Met Pro Xaa Ile Glu Arg Leu Ser Met Xaa 
        355                 360                 365             


Arg Tyr Phe Tyr Leu Phe Pro Gly Asn 
    370                 375         


<210> 5065
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<400> 5065
Xaa Asn Val Ser Trp Arg Asp Ser Xaa Met Gly Ser Ile Phe Ile Xaa 
1               5                   10                  15      


Gln Leu Ile Xaa Cys Phe Gln Lys Tyr Ser Trp Cys Cys His Leu Glu 
            20                  25                  30          


Glu Val Phe Arg Lys Glu Ala Xaa Ser Ser Pro Ala Leu Leu Asn Gln 
        35                  40                  45              


Leu Gln Gly Ala Pro Ser Leu Val Gln Leu Ala Tyr Leu Xaa Phe Cys 
    50                  55                  60                  


Ile Ser Ile Lys Val Lys Xaa Asn 
65                  70          


<210> 5066
<211> 496
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<400> 5066
Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Xaa Tyr Leu Asn 
65                  70                  75                  80  


Xaa Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Xaa Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Phe His Phe Cys Arg Met Ser Trp Ala Glu 
            100                 105                 110         


Ala Asn Ser Gln Cys Gln Xaa Gln Ser Val Pro Phe Trp Arg Arg Val 
        115                 120                 125             


Asp His Leu Leu Ile Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
    130                 135                 140                 


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
145                 150                 155                 160 


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
                165                 170                 175     


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
            180                 185                 190         


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
        195                 200                 205             


Asp Tyr Glu Glu Phe Ser Lys Gly Glu Glu Leu Cys Gly Val Met Xaa 
    210                 215                 220                 


Ile Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Xaa Leu Asp 
225                 230                 235                 240 


Lys Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile 
                245                 250                 255     


Asn Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His 
            260                 265                 270         


Ser Ile Arg Asp Arg Asn Gly Xaa His Leu Asp Ala Gly Ala Leu Xaa 
        275                 280                 285             


Xaa Xaa Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys 
    290                 295                 300                 


Xaa Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp 
305                 310                 315                 320 


His Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp 
                325                 330                 335     


Lys Gly Ile Ile Tyr Gly Xaa Asp Gly Gln Glu Ala Pro Ile Tyr Glu 
            340                 345                 350         


Leu Xaa Ser Gln Phe Xaa Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys 
        355                 360                 365             


Pro Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys 
    370                 375                 380                 


Gly Ile Pro Val Glu Xaa Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met 
385                 390                 395                 400 


Asp Leu Ser Ser Pro Gln Xaa Arg Tyr Ile Pro Asp Glu Ala Asp Phe 
                405                 410                 415     


Leu Leu Gly Met Ala Xaa Val Asn Asn Cys Val Ser Tyr Arg Asn Pro 
            420                 425                 430         


Ala Glu Gly Xaa Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu 
        435                 440                 445             


Arg Cys Pro Arg Gly Asp Asp Ile Leu Xaa Ile Leu Xaa Glu Val Asn 
    450                 455                 460                 


Tyr Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met 
465                 470                 475                 480 


Pro Gln Pro Xaa Phe Xaa Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
                485                 490                 495     


<210> 5067
<211> 116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 5067
Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Xaa Tyr Leu Asn 
65                  70                  75                  80  


Xaa Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Xaa Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu 
        115     


<210> 5068
<211> 124
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 5068
Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Xaa Tyr Leu Asn 
65                  70                  75                  80  


Xaa Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Xaa Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu 
        115                 120                 


<210> 5069
<211> 209
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<400> 5069
Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Xaa Tyr Leu Asn 
65                  70                  75                  80  


Xaa Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Xaa Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
        115                 120                 125             


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
    130                 135                 140                 


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
                165                 170                 175     


Asp Tyr Glu Glu Phe Ser Lys Asp Phe Gly Gln Ser Leu Pro Asn Glu 
            180                 185                 190         


Lys Gln Xaa Ser Gly Ile Leu Ser Asp His Gln Gln Ser Gln Phe Cys 
        195                 200                 205             


Lys 
    


<210> 5070
<211> 198
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 5070
Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Xaa Tyr Leu Asn 
65                  70                  75                  80  


Xaa Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Xaa Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
        115                 120                 125             


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
    130                 135                 140                 


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
                165                 170                 175     


Asp Tyr Glu Glu Phe Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser 
            180                 185                 190         


Pro Asp Glu Phe Ser Asn 
        195             


<210> 5071
<211> 235
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<400> 5071
Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Xaa Tyr Leu Asn 
65                  70                  75                  80  


Xaa Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Xaa Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
        115                 120                 125             


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
    130                 135                 140                 


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
                165                 170                 175     


Asp Tyr Glu Glu Phe Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser 
            180                 185                 190         


Pro Asp Glu Phe Ser Asn Asp Phe Gly Gln Ser Leu Pro Asn Glu Lys 
        195                 200                 205             


Gln Xaa Ser Gly Ile Leu Ser Asp His Gln Gln Ser Gln Phe Cys Lys 
    210                 215                 220                 


Ser Xaa Gly Glu Ser Ala Gln Xaa Ser Gln His 
225                 230                 235 


<210> 5072
<211> 479
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<400> 5072
Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Xaa Tyr Leu Asn 
65                  70                  75                  80  


Xaa Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Xaa Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
        115                 120                 125             


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
    130                 135                 140                 


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
                165                 170                 175     


Asp Tyr Glu Glu Phe Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser 
            180                 185                 190         


Pro Asp Glu Phe Ser Asn Gly Glu Glu Leu Cys Gly Val Met Xaa Ile 
        195                 200                 205             


Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Xaa Leu Asp Lys 
    210                 215                 220                 


Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile Asn 
225                 230                 235                 240 


Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His Ser 
                245                 250                 255     


Ile Arg Asp Arg Asn Gly Xaa His Leu Asp Ala Gly Ala Leu Xaa Xaa 
            260                 265                 270         


Xaa Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys Xaa 
        275                 280                 285             


Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp His 
    290                 295                 300                 


Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp Lys 
305                 310                 315                 320 


Gly Ile Ile Tyr Gly Xaa Asp Gly Gln Glu Ala Pro Ile Tyr Glu Leu 
                325                 330                 335     


Xaa Ser Gln Phe Xaa Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys Pro 
            340                 345                 350         


Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys Gly 
        355                 360                 365             


Ile Pro Val Glu Xaa Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met Asp 
    370                 375                 380                 


Leu Ser Ser Pro Gln Xaa Arg Tyr Ile Pro Asp Glu Ala Asp Phe Leu 
385                 390                 395                 400 


Leu Gly Met Ala Xaa Val Asn Asn Cys Val Ser Tyr Arg Asn Pro Ala 
                405                 410                 415     


Glu Gly Xaa Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu Arg 
            420                 425                 430         


Cys Pro Arg Gly Asp Asp Ile Leu Xaa Ile Leu Xaa Glu Val Asn Tyr 
        435                 440                 445             


Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met Pro 
    450                 455                 460                 


Gln Pro Xaa Phe Xaa Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
465                 470                 475                 


<210> 5073
<211> 395
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<400> 5073
Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Xaa Tyr Leu Asn 
65                  70                  75                  80  


Xaa Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Xaa Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
        115                 120                 125             


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
    130                 135                 140                 


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
                165                 170                 175     


Asp Tyr Glu Glu Phe Ser Lys Gly Ala Leu Xaa Xaa Xaa Phe Glu Glu 
            180                 185                 190         


Leu His Phe Glu Ile Lys Pro His Asp Asp Cys Xaa Val Glu Gln Ile 
        195                 200                 205             


Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp His Ser Asn Met Asp 
    210                 215                 220                 


Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp Lys Gly Ile Ile Tyr 
225                 230                 235                 240 


Gly Xaa Asp Gly Gln Glu Ala Pro Ile Tyr Glu Leu Xaa Ser Gln Phe 
                245                 250                 255     


Xaa Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys Pro Lys Val Phe Phe 
            260                 265                 270         


Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys Gly Ile Pro Val Glu 
        275                 280                 285             


Xaa Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met Asp Leu Ser Ser Pro 
    290                 295                 300                 


Gln Xaa Arg Tyr Ile Pro Asp Glu Ala Asp Phe Leu Leu Gly Met Ala 
305                 310                 315                 320 


Xaa Val Asn Asn Cys Val Ser Tyr Arg Asn Pro Ala Glu Gly Xaa Trp 
                325                 330                 335     


Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu Arg Cys Pro Arg Gly 
            340                 345                 350         


Asp Asp Ile Leu Xaa Ile Leu Xaa Glu Val Asn Tyr Glu Val Ser Asn 
        355                 360                 365             


Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met Pro Gln Pro Xaa Phe 
    370                 375                 380                 


Xaa Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
385                 390                 395 


<210> 5074
<211> 464
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<400> 5074
Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Xaa Tyr Leu Asn 
65                  70                  75                  80  


Xaa Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Xaa Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
        115                 120                 125             


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
    130                 135                 140                 


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
                165                 170                 175     


Asp Tyr Glu Glu Phe Ser Lys Gly Glu Glu Leu Cys Gly Val Met Xaa 
            180                 185                 190         


Ile Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Xaa Leu Asp 
        195                 200                 205             


Lys Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile 
    210                 215                 220                 


Asn Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His 
225                 230                 235                 240 


Ser Ile Arg Asp Arg Asn Gly Xaa His Leu Asp Ala Gly Ala Leu Xaa 
                245                 250                 255     


Xaa Xaa Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys 
            260                 265                 270         


Xaa Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp 
        275                 280                 285             


His Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp 
    290                 295                 300                 


Lys Gly Ile Ile Tyr Gly Xaa Asp Gly Gln Glu Ala Pro Ile Tyr Glu 
305                 310                 315                 320 


Leu Xaa Ser Gln Phe Xaa Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys 
                325                 330                 335     


Pro Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys 
            340                 345                 350         


Gly Ile Pro Val Glu Xaa Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met 
        355                 360                 365             


Asp Leu Ser Ser Pro Gln Xaa Arg Tyr Ile Pro Asp Glu Ala Asp Phe 
    370                 375                 380                 


Leu Leu Gly Met Ala Xaa Val Asn Asn Cys Val Ser Tyr Arg Asn Pro 
385                 390                 395                 400 


Ala Glu Gly Xaa Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu 
                405                 410                 415     


Arg Cys Pro Arg Gly Asp Asp Ile Leu Xaa Ile Leu Xaa Glu Val Asn 
            420                 425                 430         


Tyr Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met 
        435                 440                 445             


Pro Gln Pro Xaa Phe Xaa Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
    450                 455                 460                 


<210> 5075
<211> 278
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<400> 5075
Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Xaa Tyr Leu Asn 
65                  70                  75                  80  


Xaa Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Xaa Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
        115                 120                 125             


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
    130                 135                 140                 


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
                165                 170                 175     


Asp Tyr Glu Glu Phe Ser Lys Gly Glu Glu Leu Cys Gly Val Met Xaa 
            180                 185                 190         


Ile Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Xaa Leu Asp 
        195                 200                 205             


Lys Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile 
    210                 215                 220                 


Asn Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His 
225                 230                 235                 240 


Ser Ile Arg Asp Arg Asn Gly Xaa His Leu Asp Ala Gly Ser His Ser 
                245                 250                 255     


Val Ala Gln Ala Gly Val Gln Trp Cys Asp Leu Ser Ser Leu Gln Pro 
            260                 265                 270         


Pro Pro Pro Trp Phe Lys 
        275             


<210> 5076
<211> 58
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<400> 5076
Met Glu Gly Gly Arg Arg Ala Arg Val Val Ile Glu Ser Lys Arg Asn 
1               5                   10                  15      


Phe Phe Leu Gly Ala Phe Pro Xaa Pro Phe Pro Ala Glu His Val Glu 
            20                  25                  30          


Leu Gly Arg Leu Gly Asp Ser Glu Xaa Ala Met Val Pro Gly Lys Gly 
        35                  40                  45              


Gly Ala Asp Gly Leu Gln Gln Lys Ser Leu 
    50                  55              


<210> 5077
<211> 538
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<400> 5077
Met Glu Gly Gly Arg Arg Ala Arg Val Val Ile Glu Ser Lys Arg Asn 
1               5                   10                  15      


Phe Phe Leu Gly Ala Phe Pro Xaa Pro Phe Pro Ala Glu His Val Glu 
            20                  25                  30          


Leu Gly Arg Leu Gly Asp Ser Glu Xaa Ala Met Val Pro Gly Lys Gly 
        35                  40                  45              


Gly Ala Asp Tyr Ile Leu Leu Pro Phe Lys Lys Met Asp Phe Ser Arg 
    50                  55                  60                  


Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser Glu Asp Leu Ala Ser 
65                  70                  75                  80  


Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln Arg Lys Gln Glu Pro 
                85                  90                  95      


Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu Gln Glu Lys Arg Met 
            100                 105                 110         


Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu Leu Leu Phe Arg Ile 
        115                 120                 125             


Asn Arg Leu Asp Leu Leu Ile Xaa Tyr Leu Asn Xaa Arg Lys Glu Glu 
    130                 135                 140                 


Met Glu Arg Glu Leu Gln Xaa Pro Gly Arg Ala Gln Ile Ser Ala Tyr 
145                 150                 155                 160 


Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val Ser Arg Ser Glu Leu 
                165                 170                 175     


Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile Ser Lys Cys Lys Leu 
            180                 185                 190         


Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile Glu Met Glu Lys Arg 
        195                 200                 205             


Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu Lys Arg Val Cys Ala 
    210                 215                 220                 


Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn Asp Tyr Glu Glu Phe 
225                 230                 235                 240 


Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser Pro Asp Glu Phe Ser 
                245                 250                 255     


Asn Gly Glu Glu Leu Cys Gly Val Met Xaa Ile Ser Asp Ser Pro Arg 
            260                 265                 270         


Glu Gln Asp Ser Glu Ser Gln Xaa Leu Asp Lys Val Tyr Gln Met Lys 
        275                 280                 285             


Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile Asn Asn His Asn Phe Ala 
    290                 295                 300                 


Lys Ala Arg Glu Lys Val Pro Lys Leu His Ser Ile Arg Asp Arg Asn 
305                 310                 315                 320 


Gly Xaa His Leu Asp Ala Gly Ala Leu Xaa Xaa Xaa Phe Glu Glu Leu 
                325                 330                 335     


His Phe Glu Ile Lys Pro His Asp Asp Cys Xaa Val Glu Gln Ile Tyr 
            340                 345                 350         


Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp His Ser Asn Met Asp Cys 
        355                 360                 365             


Phe Ile Cys Cys Ile Leu Ser His Gly Asp Lys Gly Ile Ile Tyr Gly 
    370                 375                 380                 


Xaa Asp Gly Gln Glu Ala Pro Ile Tyr Glu Leu Xaa Ser Gln Phe Xaa 
385                 390                 395                 400 


Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys Pro Lys Val Phe Phe Ile 
                405                 410                 415     


Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys Gly Ile Pro Val Glu Xaa 
            420                 425                 430         


Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met Asp Leu Ser Ser Pro Gln 
        435                 440                 445             


Xaa Arg Tyr Ile Pro Asp Glu Ala Asp Phe Leu Leu Gly Met Ala Xaa 
    450                 455                 460                 


Val Asn Asn Cys Val Ser Tyr Arg Asn Pro Ala Glu Gly Xaa Trp Tyr 
465                 470                 475                 480 


Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu Arg Cys Pro Arg Gly Asp 
                485                 490                 495     


Asp Ile Leu Xaa Ile Leu Xaa Glu Val Asn Tyr Glu Val Ser Asn Lys 
            500                 505                 510         


Asp Asp Lys Lys Asn Met Gly Lys Gln Met Pro Gln Pro Xaa Phe Xaa 
        515                 520                 525             


Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
    530                 535             


<210> 5078
<211> 149
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<400> 5078
Met Leu Tyr Gln Ile Ser Glu Glu Val Ser Arg Ser Glu Leu Arg Ser 
1               5                   10                  15      


Phe Lys Phe Leu Leu Gln Glu Glu Ile Ser Lys Cys Lys Leu Asp Asp 
            20                  25                  30          


Asp Met Asn Leu Leu Asp Ile Phe Ile Glu Met Glu Lys Arg Val Ile 
        35                  40                  45              


Leu Gly Glu Gly Lys Leu Asp Ile Leu Lys Arg Val Cys Ala Gln Ile 
    50                  55                  60                  


Asn Lys Ser Leu Leu Lys Ile Ile Asn Asp Tyr Glu Glu Phe Ser Lys 
65                  70                  75                  80  


Gly Glu Glu Leu Cys Gly Val Met Xaa Ile Ser Asp Ser Pro Arg Glu 
                85                  90                  95      


Gln Asp Ser Glu Ser Gln Xaa Leu Asp Lys Val Tyr Gln Met Lys Ser 
            100                 105                 110         


Lys Pro Arg Gly Tyr Cys Leu Ile Ile Asn Asn His Asn Phe Ala Lys 
        115                 120                 125             


Ala Arg Glu Lys Val Pro Lys Leu His Ser Ile Arg Asp Arg Asn Gly 
    130                 135                 140                 


Xaa His Leu Asp Ala 
145                 


<210> 5079
<211> 83
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 5079
Asn Leu Leu Asp Ile Phe Ile Glu Met Glu Lys Arg Val Ile Leu Gly 
1               5                   10                  15      


Glu Gly Lys Leu Asp Ile Leu Lys Arg Val Cys Ala Gln Ile Asn Lys 
            20                  25                  30          


Ser Leu Leu Lys Ile Ile Asn Asp Tyr Glu Glu Phe Ser Lys Asp Phe 
        35                  40                  45              


Gly Gln Ser Leu Pro Asn Glu Lys Gln Xaa Ser Gly Ile Leu Ser Asp 
    50                  55                  60                  


His Gln Gln Ser Gln Phe Cys Lys Ser Xaa Gly Glu Ser Ala Gln Xaa 
65                  70                  75                  80  


Ser Gln His 
            


<210> 5080
<211> 258
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<400> 5080
Asn Leu Leu Asp Ile Phe Ile Glu Met Glu Lys Arg Val Ile Leu Gly 
1               5                   10                  15      


Glu Gly Lys Leu Asp Ile Leu Lys Arg Val Cys Ala Gln Ile Asn Lys 
            20                  25                  30          


Ser Leu Leu Lys Ile Ile Asn Asp Tyr Glu Glu Phe Ser Lys Gly Ala 
        35                  40                  45              


Leu Xaa Xaa Xaa Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp 
    50                  55                  60                  


Asp Cys Xaa Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu 
65                  70                  75                  80  


Met Asp His Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His 
                85                  90                  95      


Gly Asp Lys Gly Ile Ile Tyr Gly Xaa Asp Gly Gln Glu Ala Pro Ile 
            100                 105                 110         


Tyr Glu Leu Xaa Ser Gln Phe Xaa Gly Leu Lys Cys Pro Ser Leu Ala 
        115                 120                 125             


Gly Lys Pro Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr 
    130                 135                 140                 


Gln Lys Gly Ile Pro Val Glu Xaa Asp Ser Glu Glu Gln Pro Tyr Leu 
145                 150                 155                 160 


Glu Met Asp Leu Ser Ser Pro Gln Xaa Arg Tyr Ile Pro Asp Glu Ala 
                165                 170                 175     


Asp Phe Leu Leu Gly Met Ala Xaa Val Asn Asn Cys Val Ser Tyr Arg 
            180                 185                 190         


Asn Pro Ala Glu Gly Xaa Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu 
        195                 200                 205             


Arg Glu Arg Cys Pro Arg Gly Asp Asp Ile Leu Xaa Ile Leu Xaa Glu 
    210                 215                 220                 


Val Asn Tyr Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys 
225                 230                 235                 240 


Gln Met Pro Gln Pro Xaa Phe Xaa Leu Arg Lys Lys Leu Val Phe Pro 
                245                 250                 255     


Ser Asp 
        


<210> 5081
<211> 361
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<400> 5081
Met Ala Ala Asp Asp Asp Asn Gly Asp Gly Xaa Ser Leu Phe Asp Val 
1               5                   10                  15      


Phe Ser Ala Ser Pro Leu Lys Asn Asn Asp Glu Gly Ser Leu Asp Ile 
            20                  25                  30          


Tyr Ala Gly Leu Asp Ser Ala Val Ser Asp Ser Ala Ser Lys Ser Cys 
        35                  40                  45              


Val Pro Ser Arg Asn Cys Leu Asp Leu Tyr Glu Glu Ile Leu Xaa Glu 
    50                  55                  60                  


Glu Gly Xaa Ala Lys Glu Ala Xaa Tyr Asn Asp Leu Gln Val Glu Tyr 
65                  70                  75                  80  


Gly Lys Cys Gln Leu Gln Met Lys Glu Leu Met Lys Lys Phe Lys Glu 
                85                  90                  95      


Ile Gln Xaa Gln Asn Phe Ser Leu Ile Asn Glu Asn Gln Ser Leu Lys 
            100                 105                 110         


Lys Asn Ile Ser Ala Leu Ile Lys Xaa Ala Arg Val Glu Ile Asn Arg 
        115                 120                 125             


Lys Asp Glu Glu Ile Ser Asn Leu His Gln Arg Leu Ser Glu Phe Pro 
    130                 135                 140                 


His Phe Arg Asn Asn His Lys Xaa Ala Arg Xaa Phe Asp Xaa Val Lys 
145                 150                 155                 160 


Xaa Lys Asp Leu Lys Ser Arg Ser Pro His Leu Asp Asp Cys Ser Lys 
                165                 170                 175     


Xaa Asp His Arg Ala Lys Ser Asp Val Ser Lys Asp Val His His Ser 
            180                 185                 190         


Xaa Ser Leu Pro Asn Leu Glu Lys Glu Gly Lys Pro His Ser Asp Lys 
        195                 200                 205             


Arg Ser Xaa Ser His Leu Pro Xaa Ser Val Glu Lys His Cys Xaa Asn 
    210                 215                 220                 


Gly Val Trp Ser Arg Ser His Tyr Gln Val Gly Glu Gly Ser Ser Asn 
225                 230                 235                 240 


Glu Asp Ser Arg Arg Gly Arg Lys Asp Ile Arg His Ser Gln Phe Asn 
                245                 250                 255     


Arg Gly Xaa Glu Arg Val Arg Lys Asp Leu Ser Xaa Gly Cys Gly Asp 
            260                 265                 270         


Gly Glu Pro Arg Ile Leu Glu Ala Ser Gln Arg Leu Gln Gly His Pro 
        275                 280                 285             


Glu Lys Tyr Gly Lys Gly Glu Pro Lys Xaa Glu Ser Lys Ser Ser Lys 
    290                 295                 300                 


Phe Lys Ser Asn Ser Asp Ser Asp Tyr Lys Gly Glu Arg Ile Asn Ser 
305                 310                 315                 320 


Ser Trp Glu Lys Glu Xaa Pro Gly Glu Arg Ser His Ser Arg Val Asp 
                325                 330                 335     


Ser Gln Ser Asp Lys Lys Leu Glu Arg Gln Ser Glu Arg Ser Gln Asn 
            340                 345                 350         


Ile Asn Arg Lys Glu Val Lys Ser Gln 
        355                 360     


<210> 5082
<211> 1972
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1093)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1277)..(1277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1282)..(1282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1293)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1340)..(1340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1413)..(1413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1445)..(1445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1549)..(1549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1552)..(1552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1567)..(1567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1590)..(1590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1611)..(1611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1656)..(1656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1682)..(1682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1687)..(1687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1692)..(1692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1694)..(1694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1704)..(1704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1733)..(1733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1741)..(1741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1793)..(1793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1798)..(1799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1828)..(1828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1853)..(1853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1856)..(1856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1861)..(1861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1865)..(1865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1872)..(1872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1888)..(1888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1897)..(1897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1909)..(1909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1911)..(1911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1930)..(1930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1950)..(1950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1966)..(1967)
<223> Selenocysteine

<400> 5082
Met Ala Ala Asp Asp Asp Asn Gly Asp Gly Xaa Ser Leu Phe Asp Val 
1               5                   10                  15      


Phe Ser Ala Ser Pro Leu Lys Asn Asn Asp Glu Gly Ser Leu Asp Ile 
            20                  25                  30          


Tyr Ala Gly Leu Asp Ser Ala Val Ser Asp Ser Ala Ser Lys Ser Cys 
        35                  40                  45              


Val Pro Ser Arg Asn Cys Leu Asp Leu Tyr Glu Glu Ile Leu Xaa Glu 
    50                  55                  60                  


Glu Gly Xaa Ala Lys Glu Ala Xaa Tyr Asn Asp Leu Gln Val Glu Tyr 
65                  70                  75                  80  


Gly Lys Cys Gln Leu Gln Met Lys Glu Leu Met Lys Lys Phe Lys Glu 
                85                  90                  95      


Ile Gln Xaa Gln Asn Phe Ser Leu Ile Asn Glu Asn Gln Ser Leu Lys 
            100                 105                 110         


Lys Asn Ile Ser Ala Leu Ile Lys Xaa Ala Arg Val Glu Ile Asn Arg 
        115                 120                 125             


Lys Asp Glu Glu Ile Ser Asn Leu His Gln Arg Leu Ser Glu Phe Pro 
    130                 135                 140                 


His Phe Arg Asn Asn His Lys Xaa Ala Arg Xaa Phe Asp Xaa Val Lys 
145                 150                 155                 160 


Xaa Lys Asp Leu Lys Ser Arg Ser Pro His Leu Asp Asp Cys Ser Lys 
                165                 170                 175     


Xaa Asp His Arg Ala Lys Ser Asp Val Ser Lys Asp Val His His Ser 
            180                 185                 190         


Xaa Ser Leu Pro Asn Leu Glu Lys Glu Gly Lys Pro His Ser Asp Lys 
        195                 200                 205             


Arg Ser Xaa Ser His Leu Pro Xaa Ser Val Glu Lys His Cys Xaa Asn 
    210                 215                 220                 


Gly Val Trp Ser Arg Ser His Tyr Gln Val Gly Glu Gly Ser Ser Asn 
225                 230                 235                 240 


Glu Asp Ser Arg Arg Gly Arg Lys Asp Ile Arg His Ser Gln Phe Asn 
                245                 250                 255     


Arg Gly Xaa Glu Arg Val Arg Lys Asp Leu Ser Xaa Gly Cys Gly Asp 
            260                 265                 270         


Gly Glu Pro Arg Ile Leu Glu Ala Ser Gln Arg Leu Gln Gly His Pro 
        275                 280                 285             


Glu Lys Tyr Gly Lys Gly Glu Pro Lys Xaa Glu Ser Lys Ser Ser Lys 
    290                 295                 300                 


Phe Lys Ser Asn Ser Asp Ser Asp Tyr Lys Gly Glu Arg Ile Asn Ser 
305                 310                 315                 320 


Ser Trp Glu Lys Glu Xaa Pro Gly Glu Arg Ser His Ser Arg Val Asp 
                325                 330                 335     


Ser Gln Ser Asp Lys Lys Leu Glu Arg Gln Ser Glu Arg Ser Gln Asn 
            340                 345                 350         


Ile Asn Arg Lys Glu Val Lys Ser Gln Asp Lys Glu Glu Arg Lys Val 
        355                 360                 365             


Asp Gln Lys Pro Lys Ser Val Val Lys Asp Gln Asp His Trp Arg Arg 
    370                 375                 380                 


Ser Glu Arg Ala Ser Leu Pro His Ser Lys Asn Glu Ile Xaa Phe Ser 
385                 390                 395                 400 


His Asn Ser Ser Lys Tyr His Leu Glu Glu Arg Arg Gly Trp Glu Asp 
                405                 410                 415     


Cys Lys Arg Asp Lys Ser Val Asn Ser His Ser Phe Gln Asp Gly Arg 
            420                 425                 430         


Cys Pro Ser Ser Leu Ser Asn Ser Arg Xaa His Lys Asn Ile Asp Ser 
        435                 440                 445             


Lys Glu Val Asp Ala Met His Gln Trp Glu Asn Xaa Pro Leu Lys Ala 
    450                 455                 460                 


Glu Arg His Arg Xaa Glu Asp Lys Arg Lys Arg Glu Gln Glu Ser Lys 
465                 470                 475                 480 


Glu Glu Asn Arg His Ile Arg Asn Glu Lys Arg Val Pro Xaa Glu His 
                485                 490                 495     


Leu Gln Lys Xaa Asn Lys Glu Xaa Lys Lys Xaa Xaa Xaa Asp Leu Lys 
            500                 505                 510         


Lys Gln Asn Glu Pro Lys Xaa Asp Lys Gly Glu Val Leu Asp Asn Gly 
        515                 520                 525             


Val Ser Glu Gly Ala Asp Asn Lys Glu Leu Ala Met Lys Ala Glu Ser 
    530                 535                 540                 


Gly Pro Asn Glu Xaa Lys Asn Lys Asp Leu Lys Leu Ser Phe Met Lys 
545                 550                 555                 560 


Lys Leu Asn Leu Xaa Leu Ser Pro Ala Lys Lys Gln Pro Val Ser Gln 
                565                 570                 575     


Asp Asn Gln His Lys Ile Xaa Asp Ile Pro Lys Ser Ser Gly Val Cys 
            580                 585                 590         


Asp Ser Glu Ser Ser Met Gln Val Lys Xaa Val Ala Tyr Val Pro Ser 
        595                 600                 605             


Ile Ser Glu His Ile Leu Gly Glu Ala Ala Val Ser Glu His Xaa Met 
    610                 615                 620                 


Gly Glu Xaa Lys Ser Xaa Leu Leu Glu Pro Lys Val Ala Leu Leu Ala 
625                 630                 635                 640 


Val Xaa Glu Pro Arg Ile Gly Ile Ser Glu Xaa Asn Lys Glu Asp Glu 
                645                 650                 655     


Asn Ser Leu Leu Val Arg Ser Val Asp Asn Xaa Met His Cys Glu Glu 
            660                 665                 670         


Pro Ile Cys Gly Xaa Glu Xaa Ser Phe Pro Ser Pro Met Glu Ile Gln 
        675                 680                 685             


Gln Xaa Glu Ser Leu Phe Pro Ser Xaa Gly Met Lys Gln Xaa Ile Asn 
    690                 695                 700                 


Asn Gly Arg Ala Ala Ala Pro Val Val Met Asp Val Leu Gln Xaa Asp 
705                 710                 715                 720 


Val Ser Gln Asn Phe Gly Leu Glu Leu Asp Xaa Lys Arg Asn Asp Asn 
                725                 730                 735     


Ser Asp Tyr Cys Gly Ile Ser Glu Gly Met Glu Met Lys Val Ala Leu 
            740                 745                 750         


Ser Xaa Xaa Val Ser Glu Xaa Xaa Glu Ser Ile Leu Gln Pro Ser Ile 
        755                 760                 765             


Glu Glu Ala Asp Ile Leu Pro Ile Met Leu Ser Glu Asp Asn Asn Pro 
    770                 775                 780                 


Lys Phe Glu Pro Ser Val Ile Val Xaa Pro Leu Val Glu Ser Lys Ser 
785                 790                 795                 800 


Cys His Leu Glu Pro Cys Leu Pro Lys Glu Xaa Leu Asp Ser Ser Leu 
                805                 810                 815     


Gln Gln Xaa Glu Leu Met Asp His Arg Met Ala Xaa Gly Glu Xaa Asn 
            820                 825                 830         


Ser Val Tyr His Asp Asp Asp Asn Ser Val Leu Ser Ile Asp Leu Asn 
        835                 840                 845             


His Leu Arg Pro Ile Pro Glu Ala Ile Ser Pro Leu Asn Ser Pro Val 
    850                 855                 860                 


Arg Pro Val Ala Lys Val Leu Arg Asn Glu Ser Pro Pro Gln Val Pro 
865                 870                 875                 880 


Val Tyr Asn Asn Ser His Lys Asp Val Phe Leu Pro Asn Ser Ala His 
                885                 890                 895     


Ser Xaa Ser Lys Ser Gln Ser Asp Leu Asn Lys Glu Asn Gln Lys Pro 
            900                 905                 910         


Ile Tyr Lys Ser Asp Lys Cys Xaa Glu Ala Asp Xaa Cys Lys Asn Ser 
        915                 920                 925             


Pro Leu Asp Glu Leu Glu Glu Gly Glu Ile Arg Ser Asp Ser Glu Xaa 
    930                 935                 940                 


Ser Lys Pro Gln Glu Ser Phe Glu Lys Asn Ser Lys Arg Arg Val Ser 
945                 950                 955                 960 


Ala Asp Val Arg Lys Ser Lys Xaa Ile Pro Arg Arg Gly Lys Ser Xaa 
                965                 970                 975     


Val Cys Leu Asp Lys Asp Ser Arg Lys Xaa His Val Arg Ile His Gln 
            980                 985                 990         


Xaa Asn Asn Lys Trp Asn Lys Arg  Pro Asp Lys Ser Ser  Arg Ser Ser 
        995                 1000                 1005             


Lys Xaa  Glu Lys Lys Asp Lys  Val Met Ser Xaa Ser  Ser Leu Glu 
    1010                 1015                 1020             


Lys Ile  Val Pro Ile Ile Ala  Val Pro Ser Ser Glu  Gln Glu Ile 
    1025                 1030                 1035             


Met His  Met Leu Arg Met Ile  Arg Lys His Val Arg  Lys Asn Tyr 
    1040                 1045                 1050             


Met Lys  Phe Lys Ala Lys Phe  Ser Leu Ile Gln Phe  His Arg Ile 
    1055                 1060                 1065             


Ile Glu  Ser Ala Ile Leu Ser  Phe Xaa Ser Leu Ile  Lys His Leu 
    1070                 1075                 1080             


Asn Leu  His Lys Ile Ser Lys  Ser Val Xaa Xaa Leu  Gln Lys Asn 
    1085                 1090                 1095             


Leu Cys  Asp Ile Ile Glu Ser  Lys Leu Lys Gln Val  Lys Lys Asn 
    1100                 1105                 1110             


Gly Ile  Val Asp Arg Leu Phe  Glu Gln Gln Leu Pro  Asp Met Lys 
    1115                 1120                 1125             


Lys Lys  Leu Trp Lys Phe Val  Asp Asp Gln Leu Asp  Tyr Leu Phe 
    1130                 1135                 1140             


Ala Lys  Leu Lys Lys Ile Leu  Val Cys Asp Ser Lys  Ser Phe Gly 
    1145                 1150                 1155             


Arg Asp  Ser Asp Glu Gly Lys  Leu Glu Lys Xaa Ser  Lys Gln Asn 
    1160                 1165                 1170             


Ala Gln  Tyr Ser Asn Ser Gln  Lys Arg Ser Val Asp  Asn Ser Asn 
    1175                 1180                 1185             


Arg Glu  Leu Leu Lys Glu Lys  Leu Ser Lys Ser Glu  Asp Pro Val 
    1190                 1195                 1200             


His Tyr  Lys Ser Leu Val Gly  Cys Lys Lys Ser Glu  Glu Asn Tyr 
    1205                 1210                 1215             


Gln Asp  Gln Asn Asn Ser Ser  Ile Asn Xaa Val Lys  His Asp Ile 
    1220                 1225                 1230             


Lys Lys  Asn Phe Asn Ile Cys  Phe Asp Asn Ile Lys  Asn Ser Gln 
    1235                 1240                 1245             


Ser Glu  Glu Arg Ser Leu Glu  Val His Cys Pro Ser  Xaa Pro Lys 
    1250                 1255                 1260             


Ser Glu  Lys Asn Glu Gly Ser  Ser Ile Glu Asp Ala  Gln Xaa Ser 
    1265                 1270                 1275             


Gln His  Ala Xaa Leu Lys Pro  Glu Arg Ser Phe Glu  Ile Leu Xaa 
    1280                 1285                 1290             


Glu Gln  Gln Ala Ser Ser Leu  Xaa Phe Asn Leu Val  Ser Asp Ala 
    1295                 1300                 1305             


Gln Met  Gly Glu Ile Phe Lys  Ser Leu Leu Gln Gly  Ser Asp Leu 
    1310                 1315                 1320             


Leu Asp  Ser Ser Val Asn Cys  Xaa Glu Lys Ser Glu  Trp Glu Leu 
    1325                 1330                 1335             


Lys Xaa  Pro Glu Lys Gln Leu  Leu Glu Xaa Leu Lys  Cys Glu Ser 
    1340                 1345                 1350             


Ile Pro  Ala Cys Xaa Xaa Glu  Glu Leu Val Ser Gly  Val Ala Ser 
    1355                 1360                 1365             


Pro Cys  Pro Lys Met Ile Ser  Asp Asp Asn Trp Ser  Leu Leu Ser 
    1370                 1375                 1380             


Ser Glu  Lys Gly Pro Ser Leu  Ser Ser Gly Leu Ser  Leu Pro Val 
    1385                 1390                 1395             


His Pro  Asp Val Leu Asp Glu  Ser Cys Met Phe Glu  Val Ser Xaa 
    1400                 1405                 1410             


Asn Leu  Pro Leu Ser Lys Asp  Asn Val Cys Ser Val  Glu Lys Ser 
    1415                 1420                 1425             


Lys Pro  Cys Val Ser Ser Ile  Leu Leu Glu Asp Leu  Ala Val Ser 
    1430                 1435                 1440             


Leu Xaa  Val Pro Ser Pro Leu  Lys Ser Asp Gly His  Leu Ser Phe 
    1445                 1450                 1455             


Leu Lys  Pro Asp Met Ser Ser  Ser Ser Xaa Pro Glu  Glu Val Ile 
    1460                 1465                 1470             


Ser Ala  His Phe Ser Glu Asp  Ala Leu Leu Glu Glu  Glu Asp Ala 
    1475                 1480                 1485             


Ser Glu  Gln Asp Ile His Leu  Ala Leu Glu Ser Asp  Asn Ser Ser 
    1490                 1495                 1500             


Ser Lys  Ser Ser Cys Ser Ser  Ser Trp Xaa Ser Arg  Ser Val Ala 
    1505                 1510                 1515             


Pro Gly  Phe Gln Tyr His Pro  Asn Leu Pro Met His  Ala Val Ile 
    1520                 1525                 1530             


Met Glu  Lys Ser Asn Asp His  Phe Ile Val Lys Ile  Arg Arg Ala 
    1535                 1540                 1545             


Xaa Pro  Ser Xaa Ser Ser Gly  Leu Lys Gln Ser Met  Met Pro Asp 
    1550                 1555                 1560             


Glu Leu  Leu Xaa Ser Leu Pro  Arg His Gly Lys Glu  Ala Asp Glu 
    1565                 1570                 1575             


Gly Pro  Glu Lys Glu Tyr Ile  Ser Cys Gln Asn Xaa  Val Phe Lys 
    1580                 1585                 1590             


Ser Val  Glu Glu Leu Glu Asn  Ser Asn Lys Asn Val  Asp Gly Ser 
    1595                 1600                 1605             


Lys Ser  Xaa His Glu Glu Gln  Ser Ser Met Ile Gln  Xaa Gln Val 
    1610                 1615                 1620             


Pro Asp  Ile Tyr Glu Phe Leu  Lys Asp Ala Ser Asp  Lys Met Gly 
    1625                 1630                 1635             


His Ser  Asp Glu Val Ala Asp  Glu Cys Phe Lys Leu  His Gln Val 
    1640                 1645                 1650             


Trp Glu  Xaa Lys Val Pro Glu  Ser Ile Glu Glu Leu  Pro Ser Met 
    1655                 1660                 1665             


Glu Glu  Ile Ser His Ser Val  Gly Glu His Leu Pro  Asn Xaa Tyr 
    1670                 1675                 1680             


Val Asp  Leu Xaa Lys Asp Pro  Val Xaa Glu Xaa Lys  Asn Leu Gly 
    1685                 1690                 1695             


Glu Phe  Ile Glu Val Xaa Val  Leu His Ile Asp Gln  Leu Gly Cys 
    1700                 1705                 1710             


Ser Gly  Gly Asn Leu Asn Gln  Ser Ala Gln Ile Leu  Asp Asn Ser 
    1715                 1720                 1725             


Leu Gln  Ala Asp Xaa Val Gly  Ala Phe Ile Asp Leu  Xaa Gln Asp 
    1730                 1735                 1740             


Ala Ser  Ser Glu Ala Lys Ser  Glu Gly Asn His Pro  Ala Leu Ala 
    1745                 1750                 1755             


Val Glu  Asp Leu Gly Cys Gly  Val Ile Gln Val Asp  Glu Asp Asn 
    1760                 1765                 1770             


Cys Lys  Glu Glu Lys Ala Gln  Val Ala Asn Arg Pro  Leu Lys Cys 
    1775                 1780                 1785             


Ile Val  Glu Glu Xaa Tyr Ile  Asp Leu Xaa Xaa Glu  Ser Pro Ser 
    1790                 1795                 1800             


Ser Cys  Glu Val Lys Lys Asp  Glu Leu Lys Ser Glu  Pro Gly Ser 
    1805                 1810                 1815             


Asn Cys  Asp Asn Ser Glu Leu  Pro Gly Xaa Leu His  Asn Ser His 
    1820                 1825                 1830             


Lys Lys  Arg Arg Asn Ile Ser  Asp Leu Asn His Pro  His Lys Lys 
    1835                 1840                 1845             


Gln Arg  Lys Glu Xaa Asp Leu  Xaa Asn Lys Glu Lys  Xaa Lys Lys 
    1850                 1855                 1860             


Pro Xaa  Gln Asp Ser Cys Glu  Asn Xaa Glu Ala His  Gln Lys Lys 
    1865                 1870                 1875             


Ala Ser  Lys Lys Lys Ala Pro  Pro Val Xaa Lys Asp  Pro Ser Ser 
    1880                 1885                 1890             


Leu Lys  Ala Xaa Pro Gly Ile  Lys Asp Ser Ser Ala  Ala Leu Ala 
    1895                 1900                 1905             


Xaa Ser  Xaa Ser Leu Ser Ala  Lys Asn Val Ile Lys  Lys Lys Gly 
    1910                 1915                 1920             


Glu Ile  Ile Ile Leu Trp Xaa  Arg Asn Asp Asp Arg  Glu Ile Leu 
    1925                 1930                 1935             


Leu Glu  Cys Gln Lys Arg Gly  Pro Ser Phe Lys Xaa  Phe Ala Tyr 
    1940                 1945                 1950             


Leu Ala  Ala Lys Leu Asp Lys  Asn Pro Asn Gln Val  Xaa Xaa Gln 
    1955                 1960                 1965             


Phe Leu  His Leu 
    1970         


<210> 5083
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<400> 5083
Met Asp Glu Ala Asp Arg Arg Leu Leu Arg Arg Cys Arg Leu Arg Leu 
1               5                   10                  15      


Val Glu Glu Leu Gln Val Asp Gln Leu Trp Asp Ala Leu Leu Ser Arg 
            20                  25                  30          


Glu Leu Phe Arg Pro His Met Ile Glu Asp Ile Gln Arg Ala Gly Ser 
        35                  40                  45              


Gly Ser Arg Arg Asp Gln Ala Arg Gln Leu Ile Ile Asp Leu Glu Xaa 
    50                  55                  60                  


Arg Gly Ser Gln Ala Leu Pro Leu Phe Ile Ser Cys Leu Glu Asp Xaa 
65                  70                  75                  80  


Gly Gln Asp Met Leu Ala Ser Phe Leu Arg Xaa Asn Arg Cys Ser 
                85                  90                  95  


<210> 5084
<211> 266
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<400> 5084
Met Asp Glu Ala Asp Arg Arg Leu Leu Arg Arg Cys Arg Leu Arg Leu 
1               5                   10                  15      


Val Glu Glu Leu Gln Val Asp Gln Leu Trp Asp Ala Leu Leu Ser Arg 
            20                  25                  30          


Glu Leu Phe Arg Pro His Met Ile Glu Asp Ile Gln Arg Ala Gly Ser 
        35                  40                  45              


Gly Ser Arg Arg Asp Gln Ala Arg Gln Leu Ile Ile Asp Leu Glu Xaa 
    50                  55                  60                  


Arg Gly Ser Gln Ala Leu Pro Leu Phe Ile Ser Cys Leu Glu Asp Xaa 
65                  70                  75                  80  


Gly Gln Asp Met Leu Ala Ser Phe Leu Arg Xaa Asn Arg Gln Ala Ala 
                85                  90                  95      


Lys Leu Ser Lys Pro Xaa Leu Glu Asn Leu Xaa Pro Val Val Leu Arg 
            100                 105                 110         


Pro Glu Ile Arg Lys Pro Glu Val Leu Arg Pro Glu Xaa Pro Arg Pro 
        115                 120                 125             


Val Asp Ile Gly Ser Gly Gly Phe Gly Asp Val Glu Gln Lys Asp His 
    130                 135                 140                 


Gly Phe Glu Val Ala Ser Xaa Ser Pro Glu Asp Glu Ser Pro Gly Ser 
145                 150                 155                 160 


Asn Pro Glu Pro Asp Ala Xaa Pro Phe Gln Glu Gly Leu Arg Xaa Phe 
                165                 170                 175     


Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Xaa Pro Ser Asp Ile Phe 
            180                 185                 190         


Val Ser Tyr Ser Xaa Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys 
        195                 200                 205             


Ser Gly Ser Trp Tyr Val Glu Xaa Leu Asp Asp Ile Phe Glu Gln Trp 
    210                 215                 220                 


Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala 
225                 230                 235                 240 


Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe 
                245                 250                 255     


Leu Arg Lys Lys Leu Phe Phe Lys Xaa Ser 
            260                 265     


<210> 5085
<211> 254
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<400> 5085
Met Asp Glu Ala Asp Arg Arg Leu Leu Arg Arg Cys Arg Leu Arg Leu 
1               5                   10                  15      


Val Glu Glu Leu Gln Val Asp Gln Leu Trp Asp Ala Leu Leu Ser Arg 
            20                  25                  30          


Glu Leu Phe Arg Pro His Met Ile Glu Asp Ile Gln Arg Ala Gly Ser 
        35                  40                  45              


Gly Ser Arg Arg Asp Gln Ala Arg Gln Leu Ile Ile Asp Leu Glu Xaa 
    50                  55                  60                  


Arg Gly Ser Gln Ala Leu Pro Leu Phe Ile Ser Cys Leu Glu Asp Xaa 
65                  70                  75                  80  


Gly Gln Asp Met Leu Ala Ser Phe Leu Arg Xaa Asn Arg Gln Ala Ala 
                85                  90                  95      


Lys Leu Ser Lys Pro Xaa Leu Glu Asn Leu Xaa Pro Val Val Leu Arg 
            100                 105                 110         


Pro Glu Ile Arg Lys Pro Glu Val Leu Arg Pro Glu Xaa Pro Arg Pro 
        115                 120                 125             


Val Asp Ile Gly Ser Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser 
    130                 135                 140                 


Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys 
145                 150                 155                 160 


Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly 
                165                 170                 175     


Leu Arg Xaa Arg Xaa Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg 
            180                 185                 190         


Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Xaa 
        195                 200                 205             


Ala Lys Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Xaa Asp 
    210                 215                 220                 


Gly Cys Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Xaa 
225                 230                 235                 240 


Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile 
                245                 250                 


<210> 5086
<211> 416
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<400> 5086
Met Asp Glu Ala Asp Arg Arg Leu Leu Arg Arg Cys Arg Leu Arg Leu 
1               5                   10                  15      


Val Glu Glu Leu Gln Val Asp Gln Leu Trp Asp Ala Leu Leu Ser Arg 
            20                  25                  30          


Glu Leu Phe Arg Pro His Met Ile Glu Asp Ile Gln Arg Ala Gly Ser 
        35                  40                  45              


Gly Ser Arg Arg Asp Gln Ala Arg Gln Leu Ile Ile Asp Leu Glu Xaa 
    50                  55                  60                  


Arg Gly Ser Gln Ala Leu Pro Leu Phe Ile Ser Cys Leu Glu Asp Xaa 
65                  70                  75                  80  


Gly Gln Asp Met Leu Ala Ser Phe Leu Arg Xaa Asn Arg Gln Ala Ala 
                85                  90                  95      


Lys Leu Ser Lys Pro Xaa Leu Glu Asn Leu Xaa Pro Val Val Leu Arg 
            100                 105                 110         


Pro Glu Ile Arg Lys Pro Glu Val Leu Arg Pro Glu Xaa Pro Arg Pro 
        115                 120                 125             


Val Asp Ile Gly Ser Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser 
    130                 135                 140                 


Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys 
145                 150                 155                 160 


Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly 
                165                 170                 175     


Leu Arg Xaa Arg Xaa Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg 
            180                 185                 190         


Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Xaa 
        195                 200                 205             


Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His 
    210                 215                 220                 


Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln 
225                 230                 235                 240 


Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Xaa Asp Gly Cys 
                245                 250                 255     


Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Xaa Ser Cys 
            260                 265                 270         


Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly 
        275                 280                 285             


Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Xaa Ser Pro Glu 
    290                 295                 300                 


Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Xaa Pro Phe Gln 
305                 310                 315                 320 


Glu Gly Leu Arg Xaa Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro 
                325                 330                 335     


Xaa Pro Ser Asp Ile Phe Val Ser Tyr Ser Xaa Phe Pro Gly Phe Val 
            340                 345                 350         


Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu Xaa Leu Asp 
        355                 360                 365             


Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu 
    370                 375                 380                 


Leu Arg Val Ala Asn Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met 
385                 390                 395                 400 


Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys Xaa Ser 
                405                 410                 415     


<210> 5087
<211> 421
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<400> 5087
Met Asp Glu Ala Asp Arg Arg Leu Leu Arg Arg Cys Arg Leu Arg Leu 
1               5                   10                  15      


Val Glu Glu Leu Gln Val Asp Gln Leu Trp Asp Ala Leu Leu Ser Arg 
            20                  25                  30          


Glu Leu Phe Arg Pro His Met Ile Glu Asp Ile Gln Arg Ala Gly Ser 
        35                  40                  45              


Gly Ser Arg Arg Asp Gln Ala Arg Gln Leu Ile Ile Asp Leu Glu Xaa 
    50                  55                  60                  


Arg Gly Ser Gln Ala Leu Pro Leu Phe Ile Ser Cys Leu Glu Asp Xaa 
65                  70                  75                  80  


Gly Gln Asp Met Leu Ala Ser Phe Leu Arg Xaa Asn Arg Gln Ala Ala 
                85                  90                  95      


Lys Leu Ser Lys Pro Xaa Leu Glu Asn Leu Xaa Pro Val Val Leu Arg 
            100                 105                 110         


Pro Glu Ile Arg Lys Pro Glu Val Leu Arg Pro Glu Xaa Pro Arg Pro 
        115                 120                 125             


Val Asp Ile Gly Ser Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser 
    130                 135                 140                 


Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys 
145                 150                 155                 160 


Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly 
                165                 170                 175     


Leu Arg Xaa Arg Xaa Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg 
            180                 185                 190         


Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Xaa 
        195                 200                 205             


Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His 
    210                 215                 220                 


Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln 
225                 230                 235                 240 


Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Xaa Asp Gly Cys 
                245                 250                 255     


Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Xaa Ser Cys 
            260                 265                 270         


Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly 
        275                 280                 285             


Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Xaa Ser Pro Glu 
    290                 295                 300                 


Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Xaa Pro Phe Gln 
305                 310                 315                 320 


Glu Gly Leu Arg Xaa Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro 
                325                 330                 335     


Xaa Pro Ser Asp Ile Phe Val Ser Tyr Ser Xaa Phe Pro Gly Phe Val 
            340                 345                 350         


Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu Xaa Leu Asp 
        355                 360                 365             


Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu 
    370                 375                 380                 


Leu Arg Val Ser Ala Ala Phe Leu Cys Lys Gly Glu Gly Arg Leu Leu 
385                 390                 395                 400 


Arg Gly Ser Val Ser Ser Trp Gly Trp Gly Phe Gly Val Ser Arg Ala 
                405                 410                 415     


Gly Pro Asn Gln Gly 
            420     


<210> 5088
<211> 47
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<400> 5088
Met Leu Ala Ser Phe Leu Arg Xaa Asn Arg Gln Ala Ala Lys Leu Ser 
1               5                   10                  15      


Lys Pro Xaa Leu Glu Asn Leu Xaa Pro Val Val Leu Arg Pro Glu Ile 
            20                  25                  30          


Arg Lys Pro Glu Val Leu Arg Pro Glu Xaa Pro Arg Pro Val Asp 
        35                  40                  45          


<210> 5089
<211> 266
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<400> 5089
Met Leu Ala Ser Phe Leu Arg Xaa Asn Arg Gln Ala Ala Lys Leu Ser 
1               5                   10                  15      


Lys Pro Xaa Leu Glu Asn Leu Xaa Pro Val Val Leu Arg Pro Glu Ile 
            20                  25                  30          


Arg Lys Pro Glu Val Leu Arg Pro Glu Xaa Pro Arg Pro Val Asp Ile 
        35                  40                  45              


Gly Ser Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly 
    50                  55                  60                  


Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys 
65                  70                  75                  80  


Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Xaa 
                85                  90                  95      


Arg Xaa Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser 
            100                 105                 110         


Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Xaa Ala Lys Lys 
        115                 120                 125             


Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His Gly Ala Leu 
    130                 135                 140                 


Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln Ala Ser His 
145                 150                 155                 160 


Leu Gln Phe Pro Gly Ala Val Tyr Gly Xaa Asp Gly Cys Pro Val Ser 
                165                 170                 175     


Val Glu Lys Ile Val Asn Ile Phe Asn Gly Xaa Ser Cys Pro Ser Leu 
            180                 185                 190         


Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln 
        195                 200                 205             


Lys Asp His Gly Phe Glu Val Ala Ser Xaa Ser Pro Glu Asp Glu Ser 
    210                 215                 220                 


Pro Gly Ser Asn Pro Glu Pro Asp Ala Xaa Pro Phe Gln Glu Gly Leu 
225                 230                 235                 240 


Arg Xaa Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Xaa Pro Ser 
                245                 250                 255     


Asp Ile Phe Val Ser Tyr Ser Xaa Phe Pro 
            260                 265     


<210> 5090
<211> 333
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<400> 5090
Met Leu Ala Ser Phe Leu Arg Xaa Asn Arg Gln Ala Ala Lys Leu Ser 
1               5                   10                  15      


Lys Pro Xaa Leu Glu Asn Leu Xaa Pro Val Val Leu Arg Pro Glu Ile 
            20                  25                  30          


Arg Lys Pro Glu Val Leu Arg Pro Glu Xaa Pro Arg Pro Val Asp Ile 
        35                  40                  45              


Gly Ser Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly 
    50                  55                  60                  


Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys 
65                  70                  75                  80  


Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Xaa 
                85                  90                  95      


Arg Xaa Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser 
            100                 105                 110         


Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Xaa Ala Lys Lys 
        115                 120                 125             


Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His Gly Ala Leu 
    130                 135                 140                 


Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln Ala Ser His 
145                 150                 155                 160 


Leu Gln Phe Pro Gly Ala Val Tyr Gly Xaa Asp Gly Cys Pro Val Ser 
                165                 170                 175     


Val Glu Lys Ile Val Asn Ile Phe Asn Gly Xaa Ser Cys Pro Ser Leu 
            180                 185                 190         


Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln 
        195                 200                 205             


Lys Asp His Gly Phe Glu Val Ala Ser Xaa Ser Pro Glu Asp Glu Ser 
    210                 215                 220                 


Pro Gly Ser Asn Pro Glu Pro Asp Ala Xaa Pro Phe Gln Glu Gly Leu 
225                 230                 235                 240 


Arg Xaa Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Xaa Pro Ser 
                245                 250                 255     


Asp Ile Phe Val Ser Tyr Ser Xaa Phe Pro Gly Phe Val Ser Trp Arg 
            260                 265                 270         


Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu Xaa Leu Asp Asp Ile Phe 
        275                 280                 285             


Glu Gln Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val 
    290                 295                 300                 


Ala Asn Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys 
305                 310                 315                 320 


Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys Xaa Ser 
                325                 330             


<210> 5091
<211> 152
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 5091
Xaa Ala Asp Arg Arg Leu Leu Arg Arg Cys Arg Leu Arg Leu Val Glu 
1               5                   10                  15      


Glu Leu Gln Val Asp Gln Leu Trp Asp Ala Leu Leu Ser Arg Glu Leu 
            20                  25                  30          


Phe Arg Pro His Met Ile Glu Asp Ile Gln Arg Ala Gly Ser Gly Ser 
        35                  40                  45              


Arg Arg Asp Gln Ala Arg Gln Leu Ile Ile Asp Leu Glu Xaa Arg Gly 
    50                  55                  60                  


Ser Gln Ala Leu Pro Leu Phe Ile Ser Cys Leu Glu Asp Xaa Gly Gln 
65                  70                  75                  80  


Asp Met Leu Ala Ser Phe Leu Arg Xaa Asn Arg Gln Ala Ala Lys Leu 
                85                  90                  95      


Ser Lys Pro Xaa Leu Glu Asn Leu Xaa Pro Val Val Leu Arg Pro Glu 
            100                 105                 110         


Ile Arg Lys Pro Glu Val Leu Arg Pro Glu Xaa Pro Arg Pro Val Asp 
        115                 120                 125             


Ile Gly Ser Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg 
    130                 135                 140                 


Gly Asn Ala Asp Leu Xaa Val Leu 
145                 150         


<210> 5092
<211> 198
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<400> 5092
Xaa Cys Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu 
1               5                   10                  15      


Ser Gly Leu Arg Xaa Arg Xaa Gly Ser Asn Ile Asp Cys Glu Lys Leu 
            20                  25                  30          


Arg Arg Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp 
        35                  40                  45              


Leu Xaa Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln 
    50                  55                  60                  


Asp His Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly 
65                  70                  75                  80  


Cys Gln Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Xaa Asp 
                85                  90                  95      


Gly Cys Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Xaa 
            100                 105                 110         


Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala 
        115                 120                 125             


Cys Gly Gly Gly Phe Val Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp 
    130                 135                 140                 


Tyr Val Glu Xaa Leu Asp Asp Ile Phe Glu Gln Trp Ala His Ser Glu 
145                 150                 155                 160 


Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala Val Ser Val Lys 
                165                 170                 175     


Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys 
            180                 185                 190         


Leu Phe Phe Lys Xaa Ser 
        195             


<210> 5093
<211> 399
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<400> 5093
Met Lys Arg Xaa His Leu Phe Ile Val Gly Ile Tyr Phe Leu Ser Ser 
1               5                   10                  15      


Cys Arg Ala Glu Glu Gly Leu Asn Phe Pro Xaa Tyr Asp Gly Lys Asp 
            20                  25                  30          


Arg Val Val Ser Leu Ser Glu Lys Asn Phe Lys Gln Val Leu Lys Lys 
        35                  40                  45              


Tyr Asp Leu Leu Cys Leu Tyr Tyr His Glu Pro Val Ser Ser Asp Lys 
    50                  55                  60                  


Val Xaa Gln Lys Gln Phe Gln Leu Lys Glu Ile Val Leu Glu Leu Val 
65                  70                  75                  80  


Ala Gln Val Leu Glu His Lys Ala Ile Gly Phe Val Met Val Asp Ala 
                85                  90                  95      


Lys Lys Glu Ala Lys Leu Ala Lys Lys Leu Gly Phe Asp Glu Glu Gly 
            100                 105                 110         


Ser Leu Tyr Ile Leu Lys Gly Asp Arg Xaa Ile Glu Phe Asp Gly Glu 
        115                 120                 125             


Phe Ala Ala Asp Val Leu Val Glu Phe Leu Leu Asp Leu Ile Glu Asp 
    130                 135                 140                 


Pro Val Glu Ile Ile Ser Ser Lys Leu Glu Val Gln Ala Phe Glu Arg 
145                 150                 155                 160 


Ile Glu Asp Tyr Ile Lys Leu Ile Gly Phe Phe Lys Ser Glu Asp Ser 
                165                 170                 175     


Glu Tyr Tyr Lys Ala Phe Glu Glu Ala Ala Glu His Phe Gln Pro Tyr 
            180                 185                 190         


Ile Lys Phe Phe Ala Xaa Phe Asp Lys Gly Val Ala Lys Lys Leu Ser 
        195                 200                 205             


Leu Lys Met Asn Glu Val Asp Phe Tyr Glu Pro Phe Met Asp Glu Pro 
    210                 215                 220                 


Ile Ala Ile Pro Asn Lys Pro Tyr Xaa Glu Glu Glu Leu Val Glu Phe 
225                 230                 235                 240 


Val Lys Glu His Gln Arg Pro Xaa Leu Arg Arg Leu Arg Pro Glu Glu 
                245                 250                 255     


Met Phe Glu Xaa Trp Glu Asp Asp Leu Asn Gly Ile His Ile Val Ala 
            260                 265                 270         


Phe Ala Glu Lys Ser Asp Pro Asp Gly Tyr Glu Phe Leu Glu Ile Leu 
        275                 280                 285             


Lys Gln Val Ala Arg Asp Asn Xaa Asp Asn Pro Asp Leu Ser Ile Leu 
    290                 295                 300                 


Trp Ile Asp Pro Asp Asp Phe Pro Leu Leu Val Ala Tyr Trp Glu Lys 
305                 310                 315                 320 


Xaa Phe Lys Ile Asp Leu Phe Arg Pro Gln Ile Gly Val Val Asn Val 
                325                 330                 335     


Xaa Asp Ala Asp Ser Val Trp Met Glu Ile Pro Asp Asp Asp Asp Leu 
            340                 345                 350         


Pro Xaa Ala Glu Glu Leu Glu Asp Trp Ile Glu Asp Val Leu Ser Gly 
        355                 360                 365             


Lys Ile Asn Xaa Glu Asp Asp Asp Glu Asp Asp Asp Asp Asp Asp Asn 
    370                 375                 380                 


Ser Asp Glu Glu Asp Asn Asp Asp Ser Asp Asp Asp Asp Asp Glu 
385                 390                 395                 


<210> 5094
<211> 1078
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<400> 5094
Met Ala Phe Tyr Ser Cys Cys Trp Val Leu Leu Ala Leu Xaa Trp His 
1               5                   10                  15      


Xaa Ser Ala Tyr Gly Pro Asp Gln Arg Ala Gln Lys Lys Gly Asp Ile 
            20                  25                  30          


Ile Leu Gly Gly Leu Phe Pro Ile His Phe Gly Val Ala Ala Lys Asp 
        35                  40                  45              


Gln Asp Leu Lys Ser Arg Pro Glu Ser Val Glu Cys Ile Arg Tyr Asn 
    50                  55                  60                  


Phe Arg Gly Phe Arg Trp Leu Gln Ala Met Ile Phe Ala Ile Glu Glu 
65                  70                  75                  80  


Ile Asn Ser Ser Pro Ala Leu Leu Pro Asn Leu Xaa Leu Gly Tyr Arg 
                85                  90                  95      


Ile Phe Asp Xaa Cys Asn Xaa Val Ser Lys Ala Leu Glu Ala Xaa Leu 
            100                 105                 110         


Ser Phe Val Ala Gln Asn Lys Ile Asp Ser Leu Asn Leu Asp Glu Phe 
        115                 120                 125             


Cys Asn Cys Ser Glu His Ile Pro Ser Xaa Ile Ala Val Val Gly Ala 
    130                 135                 140                 


Xaa Gly Ser Gly Val Ser Xaa Ala Val Ala Asn Leu Leu Gly Leu Phe 
145                 150                 155                 160 


Tyr Ile Pro Gln Val Ser Tyr Ala Ser Ser Ser Arg Leu Leu Ser Asn 
                165                 170                 175     


Lys Asn Gln Phe Lys Ser Phe Leu Arg Xaa Ile Pro Asn Asp Glu His 
            180                 185                 190         


Gln Ala Xaa Ala Met Ala Asp Ile Ile Glu Tyr Phe Arg Trp Asn Trp 
        195                 200                 205             


Val Gly Xaa Ile Ala Ala Asp Asp Asp Tyr Gly Arg Pro Gly Ile Glu 
    210                 215                 220                 


Lys Phe Arg Glu Glu Ala Glu Glu Arg Asp Ile Cys Ile Asp Phe Ser 
225                 230                 235                 240 


Glu Leu Ile Ser Gln Tyr Ser Asp Glu Glu Glu Ile Gln His Val Val 
                245                 250                 255     


Glu Val Ile Gln Asn Ser Xaa Ala Lys Val Ile Val Val Phe Ser Ser 
            260                 265                 270         


Gly Pro Asp Leu Glu Pro Leu Ile Lys Glu Ile Val Arg Arg Asn Ile 
        275                 280                 285             


Xaa Gly Lys Ile Trp Leu Ala Ser Glu Ala Trp Ala Ser Ser Ser Leu 
    290                 295                 300                 


Ile Ala Met Pro Gln Tyr Phe His Val Val Gly Gly Xaa Ile Gly Phe 
305                 310                 315                 320 


Ala Leu Lys Ala Gly Gln Ile Pro Gly Phe Arg Glu Phe Leu Lys Lys 
                325                 330                 335     


Val His Pro Arg Lys Ser Val His Asn Gly Phe Ala Lys Glu Phe Trp 
            340                 345                 350         


Glu Glu Xaa Phe Asn Cys His Leu Gln Glu Gly Ala Lys Gly Pro Leu 
        355                 360                 365             


Pro Val Asp Xaa Phe Leu Arg Gly His Glu Glu Ser Gly Asp Arg Phe 
    370                 375                 380                 


Ser Asn Ser Ser Xaa Ala Phe Arg Pro Leu Cys Xaa Gly Asp Glu Asn 
385                 390                 395                 400 


Ile Ser Ser Val Glu Xaa Pro Tyr Ile Asp Tyr Xaa His Leu Arg Ile 
                405                 410                 415     


Ser Tyr Asn Val Tyr Leu Ala Val Tyr Ser Ile Ala His Ala Leu Gln 
            420                 425                 430         


Asp Ile Tyr Xaa Cys Leu Pro Gly Arg Gly Leu Phe Xaa Asn Gly Ser 
        435                 440                 445             


Cys Ala Asp Ile Lys Lys Val Glu Ala Trp Gln Val Leu Lys His Leu 
    450                 455                 460                 


Arg His Leu Asn Phe Xaa Asn Asn Met Gly Glu Gln Val Xaa Phe Asp 
465                 470                 475                 480 


Glu Cys Gly Asp Leu Val Gly Asn Tyr Ser Ile Ile Asn Trp His Leu 
                485                 490                 495     


Ser Pro Glu Asp Gly Ser Ile Val Phe Lys Glu Val Gly Tyr Tyr Asn 
            500                 505                 510         


Val Tyr Ala Lys Lys Gly Glu Arg Leu Phe Ile Asn Glu Glu Lys Ile 
        515                 520                 525             


Leu Trp Ser Gly Phe Ser Arg Glu Val Pro Phe Ser Asn Cys Ser Arg 
    530                 535                 540                 


Asp Cys Leu Ala Gly Xaa Arg Lys Gly Ile Ile Glu Gly Glu Pro Xaa 
545                 550                 555                 560 


Cys Cys Phe Glu Cys Val Glu Cys Pro Asp Gly Glu Tyr Ser Asp Glu 
                565                 570                 575     


Xaa Asp Ala Ser Ala Cys Asn Lys Cys Pro Asp Asp Phe Trp Ser Asn 
            580                 585                 590         


Glu Asn His Xaa Ser Cys Ile Ala Lys Glu Ile Glu Phe Leu Ser Trp 
        595                 600                 605             


Xaa Glu Pro Phe Gly Ile Ala Leu Xaa Leu Phe Ala Val Leu Gly Ile 
    610                 615                 620                 


Phe Leu Xaa Ala Phe Val Leu Gly Val Phe Ile Lys Phe Arg Asn Xaa 
625                 630                 635                 640 


Pro Ile Val Lys Ala Xaa Asn Arg Glu Leu Ser Tyr Leu Leu Leu Phe 
                645                 650                 655     


Ser Leu Leu Cys Cys Phe Ser Ser Ser Leu Phe Phe Ile Gly Glu Pro 
            660                 665                 670         


Gln Asp Trp Xaa Cys Arg Leu Arg Gln Pro Ala Phe Gly Ile Ser Phe 
        675                 680                 685             


Val Leu Cys Ile Ser Cys Ile Leu Val Lys Xaa Asn Arg Val Leu Leu 
    690                 695                 700                 


Val Phe Glu Ala Lys Ile Pro Xaa Ser Phe His Arg Lys Trp Trp Gly 
705                 710                 715                 720 


Leu Asn Leu Gln Phe Leu Leu Val Phe Leu Cys Xaa Phe Met Gln Ile 
                725                 730                 735     


Val Ile Cys Val Ile Trp Leu Tyr Xaa Ala Pro Pro Ser Ser Tyr Arg 
            740                 745                 750         


Asn Gln Glu Leu Glu Asp Glu Ile Ile Phe Ile Xaa Cys His Glu Gly 
        755                 760                 765             


Ser Leu Met Ala Leu Gly Phe Leu Ile Gly Tyr Xaa Cys Leu Leu Ala 
    770                 775                 780                 


Ala Ile Cys Phe Phe Phe Ala Phe Lys Ser Arg Lys Leu Pro Glu Asn 
785                 790                 795                 800 


Phe Asn Glu Ala Lys Phe Ile Xaa Phe Ser Met Leu Ile Phe Phe Ile 
                805                 810                 815     


Val Trp Ile Ser Phe Ile Pro Ala Tyr Ala Ser Xaa Tyr Gly Lys Phe 
            820                 825                 830         


Val Ser Ala Val Glu Val Ile Ala Ile Leu Ala Ala Ser Phe Gly Leu 
        835                 840                 845             


Leu Ala Cys Ile Phe Phe Asn Lys Ile Tyr Ile Ile Leu Phe Lys Pro 
    850                 855                 860                 


Ser Arg Asn Xaa Ile Glu Glu Val Arg Cys Ser Xaa Ala Ala His Ala 
865                 870                 875                 880 


Phe Lys Val Ala Ala Arg Ala Xaa Leu Arg Arg Ser Asn Val Ser Arg 
                885                 890                 895     


Lys Arg Ser Ser Ser Leu Gly Gly Ser Xaa Gly Ser Xaa Pro Ser Ser 
            900                 905                 910         


Ser Ile Ser Ser Lys Ser Asn Ser Glu Asp Pro Phe Pro Gln Pro Glu 
        915                 920                 925             


Arg Gln Lys Gln Gln Gln Pro Leu Ala Leu Xaa Gln Gln Glu Gln Gln 
    930                 935                 940                 


Gln Gln Pro Leu Xaa Leu Pro Gln Gln Gln Arg Ser Gln Gln Gln Pro 
945                 950                 955                 960 


Arg Cys Lys Gln Lys Val Ile Phe Gly Ser Gly Xaa Val Xaa Phe Ser 
                965                 970                 975     


Leu Ser Phe Asp Glu Pro Gln Lys Asn Ala Met Ala His Arg Asn Ser 
            980                 985                 990         


Xaa His Gln Asn Ser Leu Glu Ala  Gln Lys Ser Ser Asp  Xaa Leu Xaa 
        995                 1000                 1005             


Arg His  Glu Pro Leu Leu Pro  Leu Gln Cys Gly Glu  Xaa Asp Leu 
    1010                 1015                 1020             


Asp Leu  Xaa Val Gln Glu Xaa  Gly Leu Gln Gly Pro  Val Gly Gly 
    1025                 1030                 1035             


Asp Gln  Arg Pro Glu Val Glu  Asp Pro Glu Glu Leu  Ser Pro Ala 
    1040                 1045                 1050             


Leu Val  Val Ser Ser Ser Gln  Ser Phe Val Ile Ser  Gly Gly Gly 
    1055                 1060                 1065             


Ser Xaa  Val Xaa Glu Asn Val  Val Asn Ser 
    1070                 1075             


<210> 5095
<211> 1088
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<400> 5095
Met Ala Phe Tyr Ser Cys Cys Trp Val Leu Leu Ala Leu Xaa Trp His 
1               5                   10                  15      


Xaa Ser Ala Tyr Gly Pro Asp Gln Arg Ala Gln Lys Lys Gly Asp Ile 
            20                  25                  30          


Ile Leu Gly Gly Leu Phe Pro Ile His Phe Gly Val Ala Ala Lys Asp 
        35                  40                  45              


Gln Asp Leu Lys Ser Arg Pro Glu Ser Val Glu Cys Ile Arg Tyr Asn 
    50                  55                  60                  


Phe Arg Gly Phe Arg Trp Leu Gln Ala Met Ile Phe Ala Ile Glu Glu 
65                  70                  75                  80  


Ile Asn Ser Ser Pro Ala Leu Leu Pro Asn Leu Xaa Leu Gly Tyr Arg 
                85                  90                  95      


Ile Phe Asp Xaa Cys Asn Xaa Val Ser Lys Ala Leu Glu Ala Xaa Leu 
            100                 105                 110         


Ser Phe Val Ala Gln Asn Lys Ile Asp Ser Leu Asn Leu Asp Glu Phe 
        115                 120                 125             


Cys Asn Cys Ser Glu His Ile Pro Ser Xaa Ile Ala Val Val Gly Ala 
    130                 135                 140                 


Xaa Gly Ser Gly Val Ser Xaa Ala Val Ala Asn Leu Leu Gly Leu Phe 
145                 150                 155                 160 


Tyr Ile Pro Gln Val Ser Tyr Ala Ser Ser Ser Arg Leu Leu Ser Asn 
                165                 170                 175     


Lys Asn Gln Phe Lys Ser Phe Leu Arg Xaa Ile Pro Asn Asp Glu His 
            180                 185                 190         


Gln Ala Xaa Ala Met Ala Asp Ile Ile Glu Tyr Phe Arg Trp Asn Trp 
        195                 200                 205             


Val Gly Xaa Ile Ala Ala Asp Asp Asp Tyr Gly Arg Pro Gly Ile Glu 
    210                 215                 220                 


Lys Phe Arg Glu Glu Ala Glu Glu Arg Asp Ile Cys Ile Asp Phe Ser 
225                 230                 235                 240 


Glu Leu Ile Ser Gln Tyr Ser Asp Glu Glu Glu Ile Gln His Val Val 
                245                 250                 255     


Glu Val Ile Gln Asn Ser Xaa Ala Lys Val Ile Val Val Phe Ser Ser 
            260                 265                 270         


Gly Pro Asp Leu Glu Pro Leu Ile Lys Glu Ile Val Arg Arg Asn Ile 
        275                 280                 285             


Xaa Gly Lys Ile Trp Leu Ala Ser Glu Ala Trp Ala Ser Ser Ser Leu 
    290                 295                 300                 


Ile Ala Met Pro Gln Tyr Phe His Val Val Gly Gly Xaa Ile Gly Phe 
305                 310                 315                 320 


Ala Leu Lys Ala Gly Gln Ile Pro Gly Phe Arg Glu Phe Leu Lys Lys 
                325                 330                 335     


Val His Pro Arg Lys Ser Val His Asn Gly Phe Ala Lys Glu Phe Trp 
            340                 345                 350         


Glu Glu Xaa Phe Asn Cys His Leu Gln Glu Gly Ala Lys Gly Pro Leu 
        355                 360                 365             


Pro Val Asp Xaa Phe Leu Arg Gly His Glu Glu Ser Gly Asp Arg Phe 
    370                 375                 380                 


Ser Asn Ser Ser Xaa Ala Phe Arg Pro Leu Cys Xaa Gly Asp Glu Asn 
385                 390                 395                 400 


Ile Ser Ser Val Glu Xaa Pro Tyr Ile Asp Tyr Xaa His Leu Arg Ile 
                405                 410                 415     


Ser Tyr Asn Val Tyr Leu Ala Val Tyr Ser Ile Ala His Ala Leu Gln 
            420                 425                 430         


Asp Ile Tyr Xaa Cys Leu Pro Gly Arg Gly Leu Phe Xaa Asn Gly Ser 
        435                 440                 445             


Cys Ala Asp Ile Lys Lys Val Glu Ala Trp Gln Val Leu Lys His Leu 
    450                 455                 460                 


Arg His Leu Asn Phe Xaa Asn Asn Met Gly Glu Gln Val Xaa Phe Asp 
465                 470                 475                 480 


Glu Cys Gly Asp Leu Val Gly Asn Tyr Ser Ile Ile Asn Trp His Leu 
                485                 490                 495     


Ser Pro Glu Asp Gly Ser Ile Val Phe Lys Glu Val Gly Tyr Tyr Asn 
            500                 505                 510         


Val Tyr Ala Lys Lys Gly Glu Arg Leu Phe Ile Asn Glu Glu Lys Ile 
        515                 520                 525             


Leu Trp Ser Gly Phe Ser Arg Glu Pro Leu Xaa Phe Val Leu Ser Val 
    530                 535                 540                 


Leu Gln Val Pro Phe Ser Asn Cys Ser Arg Asp Cys Leu Ala Gly Xaa 
545                 550                 555                 560 


Arg Lys Gly Ile Ile Glu Gly Glu Pro Xaa Cys Cys Phe Glu Cys Val 
                565                 570                 575     


Glu Cys Pro Asp Gly Glu Tyr Ser Asp Glu Xaa Asp Ala Ser Ala Cys 
            580                 585                 590         


Asn Lys Cys Pro Asp Asp Phe Trp Ser Asn Glu Asn His Xaa Ser Cys 
        595                 600                 605             


Ile Ala Lys Glu Ile Glu Phe Leu Ser Trp Xaa Glu Pro Phe Gly Ile 
    610                 615                 620                 


Ala Leu Xaa Leu Phe Ala Val Leu Gly Ile Phe Leu Xaa Ala Phe Val 
625                 630                 635                 640 


Leu Gly Val Phe Ile Lys Phe Arg Asn Xaa Pro Ile Val Lys Ala Xaa 
                645                 650                 655     


Asn Arg Glu Leu Ser Tyr Leu Leu Leu Phe Ser Leu Leu Cys Cys Phe 
            660                 665                 670         


Ser Ser Ser Leu Phe Phe Ile Gly Glu Pro Gln Asp Trp Xaa Cys Arg 
        675                 680                 685             


Leu Arg Gln Pro Ala Phe Gly Ile Ser Phe Val Leu Cys Ile Ser Cys 
    690                 695                 700                 


Ile Leu Val Lys Xaa Asn Arg Val Leu Leu Val Phe Glu Ala Lys Ile 
705                 710                 715                 720 


Pro Xaa Ser Phe His Arg Lys Trp Trp Gly Leu Asn Leu Gln Phe Leu 
                725                 730                 735     


Leu Val Phe Leu Cys Xaa Phe Met Gln Ile Val Ile Cys Val Ile Trp 
            740                 745                 750         


Leu Tyr Xaa Ala Pro Pro Ser Ser Tyr Arg Asn Gln Glu Leu Glu Asp 
        755                 760                 765             


Glu Ile Ile Phe Ile Xaa Cys His Glu Gly Ser Leu Met Ala Leu Gly 
    770                 775                 780                 


Phe Leu Ile Gly Tyr Xaa Cys Leu Leu Ala Ala Ile Cys Phe Phe Phe 
785                 790                 795                 800 


Ala Phe Lys Ser Arg Lys Leu Pro Glu Asn Phe Asn Glu Ala Lys Phe 
                805                 810                 815     


Ile Xaa Phe Ser Met Leu Ile Phe Phe Ile Val Trp Ile Ser Phe Ile 
            820                 825                 830         


Pro Ala Tyr Ala Ser Xaa Tyr Gly Lys Phe Val Ser Ala Val Glu Val 
        835                 840                 845             


Ile Ala Ile Leu Ala Ala Ser Phe Gly Leu Leu Ala Cys Ile Phe Phe 
    850                 855                 860                 


Asn Lys Ile Tyr Ile Ile Leu Phe Lys Pro Ser Arg Asn Xaa Ile Glu 
865                 870                 875                 880 


Glu Val Arg Cys Ser Xaa Ala Ala His Ala Phe Lys Val Ala Ala Arg 
                885                 890                 895     


Ala Xaa Leu Arg Arg Ser Asn Val Ser Arg Lys Arg Ser Ser Ser Leu 
            900                 905                 910         


Gly Gly Ser Xaa Gly Ser Xaa Pro Ser Ser Ser Ile Ser Ser Lys Ser 
        915                 920                 925             


Asn Ser Glu Asp Pro Phe Pro Gln Pro Glu Arg Gln Lys Gln Gln Gln 
    930                 935                 940                 


Pro Leu Ala Leu Xaa Gln Gln Glu Gln Gln Gln Gln Pro Leu Xaa Leu 
945                 950                 955                 960 


Pro Gln Gln Gln Arg Ser Gln Gln Gln Pro Arg Cys Lys Gln Lys Val 
                965                 970                 975     


Ile Phe Gly Ser Gly Xaa Val Xaa Phe Ser Leu Ser Phe Asp Glu Pro 
            980                 985                 990         


Gln Lys Asn Ala Met Ala His Arg  Asn Ser Xaa His Gln  Asn Ser Leu 
        995                 1000                 1005             


Glu Ala  Gln Lys Ser Ser Asp  Xaa Leu Xaa Arg His  Glu Pro Leu 
    1010                 1015                 1020             


Leu Pro  Leu Gln Cys Gly Glu  Xaa Asp Leu Asp Leu  Xaa Val Gln 
    1025                 1030                 1035             


Glu Xaa  Gly Leu Gln Gly Pro  Val Gly Gly Asp Gln  Arg Pro Glu 
    1040                 1045                 1050             


Val Glu  Asp Pro Glu Glu Leu  Ser Pro Ala Leu Val  Val Ser Ser 
    1055                 1060                 1065             


Ser Gln  Ser Phe Val Ile Ser  Gly Gly Gly Ser Xaa  Val Xaa Glu 
    1070                 1075                 1080             


Asn Val  Val Asn Ser 
    1085             


<210> 5096
<211> 527
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<400> 5096
Met Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Gln His Trp Lys 
1               5                   10                  15      


Glu Gln Arg Ala Ala Gln Lys Ala Asp Val Leu Xaa Xaa Gly Ala Gly 
            20                  25                  30          


Asn Pro Val Gly Asp Lys Leu Asn Val Ile Xaa Val Gly Pro Arg Gly 
        35                  40                  45              


Pro Leu Leu Val Gln Asp Val Val Phe Xaa Asp Glu Met Ala His Phe 
    50                  55                  60                  


Asp Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly 
65                  70                  75                  80  


Ala Phe Gly Tyr Phe Glu Val Xaa His Asp Ile Xaa Lys Tyr Ser Lys 
                85                  90                  95      


Ala Lys Val Phe Glu His Ile Gly Lys Lys Xaa Pro Ile Ala Val Arg 
            100                 105                 110         


Phe Ser Xaa Val Ala Gly Glu Ser Gly Ser Ala Asp Xaa Val Arg Asp 
        115                 120                 125             


Pro Arg Gly Phe Ala Val Lys Phe Tyr Xaa Glu Asp Gly Asn Trp Asp 
    130                 135                 140                 


Leu Val Gly Asn Asn Xaa Pro Ile Phe Phe Ile Arg Asp Pro Ile Leu 
145                 150                 155                 160 


Phe Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Xaa His Leu 
                165                 170                 175     


Lys Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Arg Pro Glu Ser 
            180                 185                 190         


Leu His Gln Val Ser Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly 
        195                 200                 205             


His Arg His Met Asn Gly Tyr Gly Ser His Xaa Phe Lys Leu Val Asn 
    210                 215                 220                 


Ala Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Xaa Asp Gln 
225                 230                 235                 240 


Gly Ile Lys Asn Leu Ser Val Glu Asp Ala Ala Arg Leu Ser Gln Glu 
                245                 250                 255     


Asp Pro Asp Tyr Gly Ile Arg Asp Leu Phe Asn Ala Ile Ala Xaa Gly 
            260                 265                 270         


Lys Tyr Pro Ser Trp Xaa Phe Tyr Ile Gln Val Met Xaa Phe Asn Gln 
        275                 280                 285             


Ala Glu Xaa Phe Pro Phe Asn Pro Phe Asp Leu Xaa Lys Val Trp Pro 
    290                 295                 300                 


His Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg 
305                 310                 315                 320 


Asn Pro Val Asn Tyr Phe Ala Glu Val Glu Gln Ile Ala Phe Asp Pro 
                325                 330                 335     


Ser Asn Met Pro Pro Gly Ile Glu Ala Ser Pro Asp Lys Met Leu Gln 
            340                 345                 350         


Gly Arg Leu Phe Ala Tyr Pro Asp Xaa His Arg His Arg Leu Gly Pro 
        355                 360                 365             


Asn Tyr Leu His Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala 
    370                 375                 380                 


Asn Tyr Gln Arg Asp Gly Pro Met Cys Met Gln Asp Asn Gln Gly Gly 
385                 390                 395                 400 


Ala Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln Gln Pro 
                405                 410                 415     


Ser Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg Arg Phe 
            420                 425                 430         


Asn Xaa Ala Asn Asp Asp Asn Val Xaa Gln Val Arg Ala Phe Tyr Val 
        435                 440                 445             


Asn Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn Ile Ala 
    450                 455                 460                 


Gly His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala Val Lys 
465                 470                 475                 480 


Asn Phe Xaa Glu Val His Pro Asp Tyr Gly Ser His Ile Gln Ala Leu 
                485                 490                 495     


Leu Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His Xaa Phe 
            500                 505                 510         


Val Gln Ser Gly Ser His Leu Ala Ala Arg Glu Lys Ala Asn Leu 
        515                 520                 525         


<210> 5097
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<400> 5097
Met Ala Asp Glu Leu Ser Glu Lys Gln Val Tyr Asp Ala His Xaa Lys 
1               5                   10                  15      


Glu Ile Asp Leu Val Asn Arg Asp Pro Lys His Leu Asn Asp Asp Val 
            20                  25                  30          


Val Lys Ile Asp Phe Glu Asp Val Ile Ala Glu Pro Glu Gly Xaa His 
        35                  40                  45              


Ser Phe Asp Gly Ile Trp Lys Ala Ser Phe Xaa Xaa Phe Xaa Val Xaa 
    50                  55                  60                  


Lys Tyr Trp Phe Tyr Arg Leu Leu Ser Ala Leu Phe Gly Ile Pro Met 
65                  70                  75                  80  


Ala Leu Ile Trp Gly Ile Tyr Phe Ala Ile Leu Ser Phe Leu His Ile 
                85                  90                  95      


Trp Ala Val Val Pro Cys Ile Lys Ser Phe Leu Ile Glu Ile Gln Cys 
            100                 105                 110         


Ile Ser Arg Val Tyr Ser Ile Tyr Val His Xaa Val Cys Asp Pro Leu 
        115                 120                 125             


Phe Glu Ala Val Gly Lys Ile Phe Ser Asn 
    130                 135             


<210> 5098
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<400> 5098
Met Ala Asp Glu Leu Ser Glu Lys Gln Val Tyr Asp Ala His Xaa Lys 
1               5                   10                  15      


Glu Ile Asp Leu Val Asn Arg Asp Pro Lys His Leu Asn Asp Asp Val 
            20                  25                  30          


Val Lys Ile Asp Phe Glu Asp Val Ile Ala Glu Pro Glu Gly Xaa His 
        35                  40                  45              


Ser Phe Asp Gly Ile Trp Lys Ala Ser Phe Xaa Xaa Phe Xaa Val Xaa 
    50                  55                  60                  


Lys Tyr Trp Phe Tyr Arg Leu Leu Ser Ala Leu Phe Gly Ile Pro Met 
65                  70                  75                  80  


Ala Leu Ile Trp Gly Ile Tyr Phe Ala Ile Leu Ser Phe Leu His Ile 
                85                  90                  95      


Trp Ala Val Val Pro Cys Ile Lys Ser Phe Leu Ile Glu Ile Gln Cys 
            100                 105                 110         


Ile Ser Arg Val Tyr Ser Ile Tyr Val His Xaa Val Cys Asp Pro Leu 
        115                 120                 125             


Phe Glu Ala Val Gly Lys Ile Phe Ser Asn Val Arg Ile Asn Leu Gln 
    130                 135                 140                 


Lys Glu Ile 
145         


<210> 5099
<211> 178
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<400> 5099
Met Ser Gly Gly Lys Tyr Val Asp Ser Glu Gly His Leu Tyr Xaa Val 
1               5                   10                  15      


Pro Ile Arg Glu Gln Gly Asn Ile Tyr Lys Pro Asn Asn Lys Ala Met 
            20                  25                  30          


Ala Asp Glu Leu Ser Glu Lys Gln Val Tyr Asp Ala His Xaa Lys Glu 
        35                  40                  45              


Ile Asp Leu Val Asn Arg Asp Pro Lys His Leu Asn Asp Asp Val Val 
    50                  55                  60                  


Lys Ile Asp Phe Glu Asp Val Ile Ala Glu Pro Glu Gly Xaa His Ser 
65                  70                  75                  80  


Phe Asp Gly Ile Trp Lys Ala Ser Phe Xaa Xaa Phe Xaa Val Xaa Lys 
                85                  90                  95      


Tyr Trp Phe Tyr Arg Leu Leu Ser Ala Leu Phe Gly Ile Pro Met Ala 
            100                 105                 110         


Leu Ile Trp Gly Ile Tyr Phe Ala Ile Leu Ser Phe Leu His Ile Trp 
        115                 120                 125             


Ala Val Val Pro Cys Ile Lys Ser Phe Leu Ile Glu Ile Gln Cys Ile 
    130                 135                 140                 


Ser Arg Val Tyr Ser Ile Tyr Val His Xaa Val Cys Asp Pro Leu Phe 
145                 150                 155                 160 


Glu Ala Val Gly Lys Ile Phe Ser Asn Val Arg Ile Asn Leu Gln Lys 
                165                 170                 175     


Glu Ile 
        


<210> 5100
<211> 167
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<400> 5100
Met Ser Gly Gly Lys Tyr Val Asp Ser Glu Gly Asn Ile Tyr Lys Pro 
1               5                   10                  15      


Asn Asn Lys Ala Met Ala Asp Glu Leu Ser Glu Lys Gln Val Tyr Asp 
            20                  25                  30          


Ala His Xaa Lys Glu Ile Asp Leu Val Asn Arg Asp Pro Lys His Leu 
        35                  40                  45              


Asn Asp Asp Val Val Lys Ile Asp Phe Glu Asp Val Ile Ala Glu Pro 
    50                  55                  60                  


Glu Gly Xaa His Ser Phe Asp Gly Ile Trp Lys Ala Ser Phe Xaa Xaa 
65                  70                  75                  80  


Phe Xaa Val Xaa Lys Tyr Trp Phe Tyr Arg Leu Leu Ser Ala Leu Phe 
                85                  90                  95      


Gly Ile Pro Met Ala Leu Ile Trp Gly Ile Tyr Phe Ala Ile Leu Ser 
            100                 105                 110         


Phe Leu His Ile Trp Ala Val Val Pro Cys Ile Lys Ser Phe Leu Ile 
        115                 120                 125             


Glu Ile Gln Cys Ile Ser Arg Val Tyr Ser Ile Tyr Val His Xaa Val 
    130                 135                 140                 


Cys Asp Pro Leu Phe Glu Ala Val Gly Lys Ile Phe Ser Asn Val Arg 
145                 150                 155                 160 


Ile Asn Leu Gln Lys Glu Ile 
                165         


<210> 5101
<211> 86
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 5101
Met Ser Gly Gly Lys Tyr Val Asp Ser Glu Val Gly Ile Arg Gly Gly 
1               5                   10                  15      


Ala Pro Ala Arg Ala Cys Gly Glu Cys Pro Leu Leu Leu Ser Ala Ser 
            20                  25                  30          


Pro Asn Ile Pro Xaa Ala Ala Leu Ala Pro Ala Leu Ser Pro Leu Arg 
        35                  40                  45              


Ser Xaa Pro Leu Ala Leu Ala Pro Leu Arg Asn Gly Pro Gly Arg Gly 
    50                  55                  60                  


Gly Glu Glu Lys Pro Gly Met Phe Tyr Val Phe Leu Met Glu Arg Gly 
65                  70                  75                  80  


Pro Arg Glu Pro Leu Ser 
                85      


<210> 5102
<211> 112
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<400> 5102
Met Gly Leu Glu Xaa Glu Lys Ala Asp Val Gln Leu Phe Met Asp Asp 
1               5                   10                  15      


Asp Ser Tyr Ser His His Ser Gly Leu Glu Tyr Ala Asp Pro Glu Lys 
            20                  25                  30          


Phe Ala Asp Ser Asp Gln Asp Arg Asp Pro His Arg Leu Asn Ser His 
        35                  40                  45              


Leu Lys Asp Phe Asn Ala Phe Cys Lys Asp Leu Pro Asn Gly Ser Ala 
    50                  55                  60                  


Phe Ser Ala Asp Asn Met Glu Glu Cys Asp Arg Cys Tyr His Cys Ser 
65                  70                  75                  80  


Ile Val Tyr Glu Arg Arg Xaa Met Leu Leu Phe Cys Gln Pro Ala Xaa 
                85                  90                  95      


Glu Pro Gly Leu Asn Xaa Trp Xaa Pro Gly Leu Glu Ile Gly Ile Leu 
            100                 105                 110         


<210> 5103
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<400> 5103
Met Gly Leu Glu Xaa Glu Lys Ala Asp Val Gln Leu Phe Met Asp Asp 
1               5                   10                  15      


Asp Ser Tyr Ser His His Ser Gly Leu Glu Tyr Ala Asp Pro Glu Lys 
            20                  25                  30          


Phe Ala Asp Ser Asp Gln Asp Arg Asp Pro His Arg Leu Asn Ser His 
        35                  40                  45              


Leu Lys Leu Gly Phe Glu Asp Val Ile Ala Glu Pro Val Xaa Xaa His 
    50                  55                  60                  


Ser Phe Asp Lys Val Trp Ile Cys Ser His Ala Leu Phe Glu Ile Ser 
65                  70                  75                  80  


Lys Tyr Val Met Tyr Lys Phe Leu Xaa Val Phe Leu Ala Ile Pro Leu 
                85                  90                  95      


Ala Phe Ile Ala Gly Ile Leu Phe Ala Xaa Leu Ser Cys Leu His Ile 
            100                 105                 110         


Trp 
    


<210> 5104
<211> 162
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<400> 5104
Met Gly Leu Glu Xaa Glu Lys Ala Asp Val Gln Leu Phe Met Asp Asp 
1               5                   10                  15      


Asp Ser Tyr Ser His His Ser Gly Leu Glu Tyr Ala Asp Pro Glu Lys 
            20                  25                  30          


Phe Ala Asp Ser Asp Gln Asp Arg Asp Pro His Arg Leu Asn Ser His 
        35                  40                  45              


Leu Lys Leu Gly Phe Glu Asp Val Ile Ala Glu Pro Val Xaa Xaa His 
    50                  55                  60                  


Ser Phe Asp Lys Val Trp Ile Cys Ser His Ala Leu Phe Glu Ile Ser 
65                  70                  75                  80  


Lys Tyr Val Met Tyr Lys Phe Leu Xaa Val Phe Leu Ala Ile Pro Leu 
                85                  90                  95      


Ala Phe Ile Ala Gly Ile Leu Phe Ala Xaa Leu Ser Cys Leu His Ile 
            100                 105                 110         


Trp Ile Leu Met Pro Phe Val Lys Xaa Cys Leu Met Val Leu Pro Ser 
        115                 120                 125             


Val Gln Xaa Ile Trp Lys Ser Val Xaa Asp Val Ile Ile Ala Pro Leu 
    130                 135                 140                 


Cys Xaa Ser Val Gly Arg Cys Phe Ser Ser Val Ser Leu Gln Leu Ser 
145                 150                 155                 160 


Gln Asp 
        


<210> 5105
<211> 151
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 5105
Met Met Ala Glu Glu His Xaa Asp Leu Glu Ala Gln Ile Val Lys Asp 
1               5                   10                  15      


Ile His Cys Lys Glu Ile Asp Leu Val Asn Arg Asp Pro Lys Asn Ile 
            20                  25                  30          


Asn Glu Asp Ile Val Lys Val Asp Phe Glu Asp Val Ile Ala Glu Pro 
        35                  40                  45              


Val Gly Xaa Tyr Ser Phe Asp Gly Val Trp Lys Val Ser Tyr Xaa Xaa 
    50                  55                  60                  


Phe Xaa Val Ser Lys Tyr Trp Cys Tyr Arg Leu Leu Ser Xaa Leu Leu 
65                  70                  75                  80  


Gly Val Pro Leu Ala Leu Leu Trp Gly Phe Leu Phe Ala Cys Ile Ser 
                85                  90                  95      


Phe Cys His Ile Trp Ala Val Val Pro Cys Ile Lys Ser Tyr Leu Ile 
            100                 105                 110         


Glu Ile Gln Cys Ile Ser His Ile Tyr Ser Leu Cys Ile Arg Xaa Phe 
        115                 120                 125             


Cys Asn Pro Leu Phe Ala Ala Leu Gly Gln Val Cys Ser Ser Ile Lys 
    130                 135                 140                 


Val Val Leu Arg Lys Glu Val 
145                 150     


<210> 5106
<211> 604
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<400> 5106
Met Ala Lys Glu Ser Gly Ile Ser Leu Lys Glu Ile Gln Val Leu Ala 
1               5                   10                  15      


Arg Gln Trp Lys Val Gly Pro Glu Lys Arg Val Pro Ala Met Pro Gly 
            20                  25                  30          


Ser Pro Val Glu Val Lys Ile Gln Ser Arg Ser Ser Pro Pro Xaa Met 
        35                  40                  45              


Pro Pro Leu Pro Pro Ile Asn Pro Gly Gly Pro Arg Pro Val Ser Phe 
    50                  55                  60                  


Xaa Pro Xaa Ala Leu Ser Asn Gly Ile Asn His Ser Pro Pro Xaa Leu 
65                  70                  75                  80  


Asn Gly Ala Pro Ser Pro Pro Gln Arg Phe Ser Asn Gly Pro Ala Ser 
                85                  90                  95      


Ser Xaa Ser Ser Ala Leu Xaa Asn Gln Gln Leu Pro Ala Xaa Cys Gly 
            100                 105                 110         


Ala Arg Gln Leu Ser Lys Leu Lys Arg Phe Leu Xaa Xaa Leu Gln Gln 
        115                 120                 125             


Phe Gly Asn Asp Ile Ser Pro Glu Ile Gly Glu Lys Val Arg Xaa Leu 
    130                 135                 140                 


Val Leu Ala Leu Val Asn Ser Xaa Val Xaa Ile Glu Glu Phe His Cys 
145                 150                 155                 160 


Lys Leu Gln Glu Ala Xaa Asn Phe Pro Leu Arg Pro Phe Val Ile Pro 
                165                 170                 175     


Phe Leu Lys Ala Asn Leu Pro Leu Leu Gln Arg Glu Leu Leu His Cys 
            180                 185                 190         


Ala Arg Ala Ala Lys Gln Xaa Pro Ser Gln Tyr Leu Ala Gln His Glu 
        195                 200                 205             


His Leu Leu Leu Asn Xaa Ser Ile Ala Ser Pro Ala Asp Ser Ser Glu 
    210                 215                 220                 


Leu Leu Met Glu Val His Gly Asn Gly Lys Arg Pro Ser Pro Glu Arg 
225                 230                 235                 240 


Arg Glu Glu Asn Ser Phe Asp Arg Asp Xaa Ile Ala Pro Glu Pro Pro 
                245                 250                 255     


Ala Lys Arg Val Cys Xaa Ile Ser Pro Ala Pro Arg His Ser Pro Ala 
            260                 265                 270         


Leu Xaa Val Pro Leu Met Asn Pro Gly Gly Gln Phe His Pro Xaa Pro 
        275                 280                 285             


Pro Pro Leu Gln His Tyr Xaa Leu Glu Asp Ile Ala Xaa Ser His Leu 
    290                 295                 300                 


Tyr Arg Glu Pro Asn Lys Met Leu Glu His Arg Glu Val Arg Asp Arg 
305                 310                 315                 320 


His His Ser Leu Gly Leu Asn Gly Gly Tyr Gln Asp Glu Leu Val Asp 
                325                 330                 335     


His Arg Leu Xaa Glu Arg Glu Trp Ala Asp Glu Trp Lys His Leu Asp 
            340                 345                 350         


His Ala Leu Asn Cys Ile Met Glu Met Val Glu Lys Xaa Arg Arg Ser 
        355                 360                 365             


Met Ala Val Leu Arg Arg Cys Gln Glu Ser Asp Arg Glu Glu Leu Asn 
    370                 375                 380                 


Tyr Trp Lys Arg Arg Tyr Asn Glu Asn Xaa Glu Leu Arg Lys Xaa Gly 
385                 390                 395                 400 


Xaa Glu Leu Val Ser Arg Gln His Ser Pro Gly Ser Ala Asp Ser Leu 
                405                 410                 415     


Ser Asn Asp Ser Gln Arg Glu Phe Asn Ser Arg Pro Gly Xaa Gly Tyr 
            420                 425                 430         


Val Pro Val Glu Phe Trp Lys Lys Xaa Glu Glu Ala Val Asn Lys Val 
        435                 440                 445             


Lys Ile Gln Ala Met Ser Glu Val Gln Lys Ala Val Ala Glu Ala Glu 
    450                 455                 460                 


Gln Lys Ala Phe Glu Val Ile Ala Xaa Glu Arg Ala Arg Met Glu Gln 
465                 470                 475                 480 


Xaa Ile Ala Asp Val Lys Arg Gln Ala Ala Glu Asp Ala Phe Leu Val 
                485                 490                 495     


Ile Asn Glu Gln Glu Glu Ser Xaa Glu Asn Cys Trp Asn Cys Gly Arg 
            500                 505                 510         


Lys Ala Ser Glu Xaa Cys Ser Gly Cys Asn Ile Ala Arg Tyr Cys Gly 
        515                 520                 525             


Ser Phe Cys Gln His Lys Asp Trp Glu Arg His His Arg Leu Cys Gly 
    530                 535                 540                 


Gln Asn Leu His Gly Gln Ser Pro His Gly Gln Gly Arg Pro Leu Leu 
545                 550                 555                 560 


Pro Val Gly Arg Gly Ser Ser Ala Arg Ser Ala Asp Cys Ser Val Pro 
                565                 570                 575     


Ser Pro Ala Leu Asp Lys Xaa Ser Ala Xaa Xaa Ser Arg Ser Ser Xaa 
            580                 585                 590         


Pro Ala Ser Val Xaa Ala Ile Asp Xaa Asn Gly Leu 
        595                 600                 


<210> 5107
<211> 614
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<400> 5107
Met Gly Phe His His Val Gly Gln Ala Arg Leu Glu Leu Leu Xaa Ser 
1               5                   10                  15      


Gly Asp Leu Pro Ala Leu Ala Ser Gln Arg Ala Gly Ile Xaa Val Gly 
            20                  25                  30          


Pro Glu Lys Arg Val Pro Ala Met Pro Gly Ser Pro Val Glu Val Lys 
        35                  40                  45              


Ile Gln Ser Arg Ser Ser Pro Pro Xaa Met Pro Pro Leu Pro Pro Ile 
    50                  55                  60                  


Asn Pro Gly Gly Pro Arg Pro Val Ser Phe Xaa Pro Xaa Ala Leu Ser 
65                  70                  75                  80  


Asn Gly Ile Asn His Ser Pro Pro Xaa Leu Asn Gly Ala Pro Ser Pro 
                85                  90                  95      


Pro Gln Arg Phe Ser Asn Gly Pro Ala Ser Ser Xaa Ser Ser Ala Leu 
            100                 105                 110         


Xaa Asn Gln Gln Leu Pro Ala Xaa Cys Gly Ala Arg Gln Leu Ser Lys 
        115                 120                 125             


Leu Lys Arg Phe Leu Xaa Xaa Leu Gln Gln Phe Gly Asn Asp Ile Ser 
    130                 135                 140                 


Pro Glu Ile Gly Glu Lys Val Arg Xaa Leu Val Leu Ala Leu Val Asn 
145                 150                 155                 160 


Ser Xaa Val Xaa Ile Glu Glu Phe His Cys Lys Leu Gln Glu Ala Xaa 
                165                 170                 175     


Asn Phe Pro Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala Asn Leu 
            180                 185                 190         


Pro Leu Leu Gln Arg Glu Leu Leu His Cys Ala Arg Ala Ala Lys Gln 
        195                 200                 205             


Xaa Pro Ser Gln Tyr Leu Ala Gln His Glu His Leu Leu Leu Asn Xaa 
    210                 215                 220                 


Ser Ile Ala Ser Pro Ala Asp Ser Ser Glu Leu Leu Met Glu Val His 
225                 230                 235                 240 


Gly Asn Gly Lys Arg Pro Ser Pro Glu Arg Arg Glu Glu Asn Ser Phe 
                245                 250                 255     


Asp Arg Asp Xaa Ile Ala Pro Glu Pro Pro Ala Lys Arg Val Cys Xaa 
            260                 265                 270         


Ile Ser Pro Ala Pro Arg His Ser Pro Ala Leu Xaa Val Pro Leu Met 
        275                 280                 285             


Asn Pro Gly Gly Gln Phe His Pro Xaa Pro Pro Pro Leu Gln His Tyr 
    290                 295                 300                 


Xaa Leu Glu Asp Ile Ala Xaa Ser His Leu Tyr Arg Glu Pro Asn Lys 
305                 310                 315                 320 


Met Leu Glu His Arg Glu Val Arg Asp Arg His His Ser Leu Gly Leu 
                325                 330                 335     


Asn Gly Gly Tyr Gln Asp Glu Leu Val Asp His Arg Leu Xaa Glu Arg 
            340                 345                 350         


Glu Trp Ala Asp Glu Trp Lys His Leu Asp His Ala Leu Asn Cys Ile 
        355                 360                 365             


Met Glu Met Val Glu Lys Xaa Arg Arg Ser Met Ala Val Leu Arg Arg 
    370                 375                 380                 


Cys Gln Glu Ser Asp Arg Glu Glu Leu Asn Tyr Trp Lys Arg Arg Tyr 
385                 390                 395                 400 


Asn Glu Asn Xaa Glu Leu Arg Lys Xaa Gly Xaa Glu Leu Val Ser Arg 
                405                 410                 415     


Gln His Ser Pro Gly Ser Ala Asp Ser Leu Ser Asn Asp Ser Gln Arg 
            420                 425                 430         


Glu Phe Asn Ser Arg Pro Gly Xaa Gly Tyr Val Pro Val Glu Phe Trp 
        435                 440                 445             


Lys Lys Xaa Glu Glu Ala Val Asn Lys Val Lys Ile Gln Ala Met Ser 
    450                 455                 460                 


Glu Val Gln Lys Ala Val Ala Glu Ala Glu Gln Lys Ala Phe Glu Val 
465                 470                 475                 480 


Ile Ala Xaa Glu Arg Ala Arg Met Glu Gln Xaa Ile Ala Asp Val Lys 
                485                 490                 495     


Arg Gln Ala Ala Glu Asp Ala Phe Leu Val Ile Asn Glu Gln Glu Glu 
            500                 505                 510         


Ser Xaa Glu Asn Cys Trp Asn Cys Gly Arg Lys Ala Ser Glu Xaa Cys 
        515                 520                 525             


Ser Gly Cys Asn Ile Ala Arg Tyr Cys Gly Ser Phe Cys Gln His Lys 
    530                 535                 540                 


Asp Trp Glu Arg His His Arg Leu Cys Gly Gln Asn Leu His Gly Gln 
545                 550                 555                 560 


Ser Pro His Gly Gln Gly Arg Pro Leu Leu Pro Val Gly Arg Gly Ser 
                565                 570                 575     


Ser Ala Arg Ser Ala Asp Cys Ser Val Pro Ser Pro Ala Leu Asp Lys 
            580                 585                 590         


Xaa Ser Ala Xaa Xaa Ser Arg Ser Ser Xaa Pro Ala Ser Val Xaa Ala 
        595                 600                 605             


Ile Asp Xaa Asn Gly Leu 
    610                 


<210> 5108
<211> 575
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<400> 5108
Met Pro Gly Ser Pro Val Glu Val Lys Ile Gln Ser Arg Ser Ser Pro 
1               5                   10                  15      


Pro Xaa Met Pro Pro Leu Pro Pro Ile Asn Pro Gly Gly Pro Arg Pro 
            20                  25                  30          


Val Ser Phe Xaa Pro Xaa Ala Leu Ser Asn Gly Ile Asn His Ser Pro 
        35                  40                  45              


Pro Xaa Leu Asn Gly Ala Pro Ser Pro Pro Gln Arg Phe Ser Asn Gly 
    50                  55                  60                  


Pro Ala Ser Ser Xaa Ser Ser Ala Leu Xaa Asn Gln Gln Leu Pro Ala 
65                  70                  75                  80  


Xaa Cys Gly Ala Arg Gln Leu Ser Lys Leu Lys Arg Phe Leu Xaa Xaa 
                85                  90                  95      


Leu Gln Gln Phe Gly Asn Asp Ile Ser Pro Glu Ile Gly Glu Lys Val 
            100                 105                 110         


Arg Xaa Leu Val Leu Ala Leu Val Asn Ser Xaa Val Xaa Ile Glu Glu 
        115                 120                 125             


Phe His Cys Lys Leu Gln Glu Ala Xaa Asn Phe Pro Leu Arg Pro Phe 
    130                 135                 140                 


Val Ile Pro Phe Leu Lys Ala Asn Leu Pro Leu Leu Gln Arg Glu Leu 
145                 150                 155                 160 


Leu His Cys Ala Arg Ala Ala Lys Gln Xaa Pro Ser Gln Tyr Leu Ala 
                165                 170                 175     


Gln His Glu His Leu Leu Leu Asn Xaa Ser Ile Ala Ser Pro Ala Asp 
            180                 185                 190         


Ser Ser Glu Leu Leu Met Glu Val His Gly Asn Gly Lys Arg Pro Ser 
        195                 200                 205             


Pro Glu Arg Arg Glu Glu Asn Ser Phe Asp Arg Asp Xaa Ile Ala Pro 
    210                 215                 220                 


Glu Pro Pro Ala Lys Arg Val Cys Xaa Ile Ser Pro Ala Pro Arg His 
225                 230                 235                 240 


Ser Pro Ala Leu Xaa Val Pro Leu Met Asn Pro Gly Gly Gln Phe His 
                245                 250                 255     


Pro Xaa Pro Pro Pro Leu Gln His Tyr Xaa Leu Glu Asp Ile Ala Xaa 
            260                 265                 270         


Ser His Leu Tyr Arg Glu Pro Asn Lys Met Leu Glu His Arg Glu Val 
        275                 280                 285             


Arg Asp Arg His His Ser Leu Gly Leu Asn Gly Gly Tyr Gln Asp Glu 
    290                 295                 300                 


Leu Val Asp His Arg Leu Xaa Glu Arg Glu Trp Ala Asp Glu Trp Lys 
305                 310                 315                 320 


His Leu Asp His Ala Leu Asn Cys Ile Met Glu Met Val Glu Lys Xaa 
                325                 330                 335     


Arg Arg Ser Met Ala Val Leu Arg Arg Cys Gln Glu Ser Asp Arg Glu 
            340                 345                 350         


Glu Leu Asn Tyr Trp Lys Arg Arg Tyr Asn Glu Asn Xaa Glu Leu Arg 
        355                 360                 365             


Lys Xaa Gly Xaa Glu Leu Val Ser Arg Gln His Ser Pro Gly Ser Ala 
    370                 375                 380                 


Asp Ser Leu Ser Asn Asp Ser Gln Arg Glu Phe Asn Ser Arg Pro Gly 
385                 390                 395                 400 


Xaa Gly Tyr Val Pro Val Glu Phe Trp Lys Lys Xaa Glu Glu Ala Val 
                405                 410                 415     


Asn Lys Val Lys Ile Gln Ala Met Ser Glu Val Gln Lys Ala Val Ala 
            420                 425                 430         


Glu Ala Glu Gln Lys Ala Phe Glu Val Ile Ala Xaa Glu Arg Ala Arg 
        435                 440                 445             


Met Glu Gln Xaa Ile Ala Asp Val Lys Arg Gln Ala Ala Glu Asp Ala 
    450                 455                 460                 


Phe Leu Val Ile Asn Glu Gln Glu Glu Ser Xaa Glu Asn Cys Trp Asn 
465                 470                 475                 480 


Cys Gly Arg Lys Ala Ser Glu Xaa Cys Ser Gly Cys Asn Ile Ala Arg 
                485                 490                 495     


Tyr Cys Gly Ser Phe Cys Gln His Lys Asp Trp Glu Arg His His Arg 
            500                 505                 510         


Leu Cys Gly Gln Asn Leu His Gly Gln Ser Pro His Gly Gln Gly Arg 
        515                 520                 525             


Pro Leu Leu Pro Val Gly Arg Gly Ser Ser Ala Arg Ser Ala Asp Cys 
    530                 535                 540                 


Ser Val Pro Ser Pro Ala Leu Asp Lys Xaa Ser Ala Xaa Xaa Ser Arg 
545                 550                 555                 560 


Ser Ser Xaa Pro Ala Ser Val Xaa Ala Ile Asp Xaa Asn Gly Leu 
                565                 570                 575 


<210> 5109
<211> 263
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<400> 5109
Met Pro Gly Ser Pro Val Glu Val Lys Ile Gln Ser Arg Ser Ser Pro 
1               5                   10                  15      


Pro Xaa Met Pro Pro Leu Pro Pro Ile Asn Pro Gly Gly Pro Arg Pro 
            20                  25                  30          


Val Ser Phe Xaa Pro Xaa Ala Leu Ser Asn Gly Ile Asn His Ser Pro 
        35                  40                  45              


Pro Xaa Leu Asn Gly Ala Pro Ser Pro Pro Gln Arg Phe Ser Asn Gly 
    50                  55                  60                  


Pro Ala Ser Ser Xaa Ser Ser Ala Leu Xaa Asn Gln Gln Leu Pro Ala 
65                  70                  75                  80  


Xaa Cys Gly Ala Arg Gln Leu Ser Lys Leu Lys Arg Phe Leu Xaa Xaa 
                85                  90                  95      


Leu Gln Gln Phe Gly Asn Asp Ile Ser Pro Glu Ile Gly Glu Lys Val 
            100                 105                 110         


Arg Xaa Leu Val Leu Ala Leu Val Asn Ser Xaa Val Xaa Ile Glu Glu 
        115                 120                 125             


Phe His Cys Lys Leu Gln Glu Ala Xaa Asn Phe Pro Leu Arg Pro Phe 
    130                 135                 140                 


Val Ile Pro Phe Leu Lys Ala Asn Leu Pro Leu Leu Gln Arg Glu Leu 
145                 150                 155                 160 


Leu His Cys Ala Arg Ala Ala Lys Gln Xaa Pro Ser Gln Tyr Leu Ala 
                165                 170                 175     


Gln His Glu His Leu Leu Leu Asn Xaa Ser Ile Ala Ser Pro Ala Asp 
            180                 185                 190         


Ser Ser Glu Leu Leu Met Glu Val His Gly Asn Gly Lys Arg Pro Ser 
        195                 200                 205             


Pro Glu Ser Cys Ile Ile His Leu Lys Ser Met Gly Val Ala Ser Arg 
    210                 215                 220                 


His Glu Tyr Phe Ser Gly Xaa Leu Gln Met Pro Ala His Pro Val Arg 
225                 230                 235                 240 


Asn Ser Xaa Leu Glu Asn Leu Trp Val Asp Cys Ser Arg Ser Leu Arg 
                245                 250                 255     


Ser Xaa Val Leu Pro Phe Pro 
            260             


<210> 5110
<211> 152
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<400> 5110
Met Ser Glu Val Gln Lys Ala Val Ala Glu Ala Glu Gln Lys Ala Phe 
1               5                   10                  15      


Glu Val Ile Ala Xaa Glu Arg Ala Arg Met Glu Gln Xaa Ile Ala Asp 
            20                  25                  30          


Val Lys Arg Gln Ala Ala Glu Asp Ala Phe Leu Val Ile Asn Glu Gln 
        35                  40                  45              


Glu Glu Ser Xaa Glu Asn Cys Trp Asn Cys Gly Arg Lys Ala Ser Glu 
    50                  55                  60                  


Xaa Cys Ser Gly Cys Asn Ile Ala Arg Tyr Cys Gly Ser Phe Cys Gln 
65                  70                  75                  80  


His Lys Asp Trp Glu Arg His His Arg Leu Cys Gly Gln Asn Leu His 
                85                  90                  95      


Gly Gln Ser Pro His Gly Gln Gly Arg Pro Leu Leu Pro Val Gly Arg 
            100                 105                 110         


Gly Ser Ser Ala Arg Ser Ala Asp Cys Ser Val Pro Ser Pro Ala Leu 
        115                 120                 125             


Asp Lys Xaa Ser Ala Xaa Xaa Ser Arg Ser Ser Xaa Pro Ala Ser Val 
    130                 135                 140                 


Xaa Ala Ile Asp Xaa Asn Gly Leu 
145                 150         


<210> 5111
<211> 595
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<400> 5111
Met Val Gly Val Pro Gly Ala Ala Ala Phe Gln Leu Gly Pro Glu Lys 
1               5                   10                  15      


Arg Val Pro Ala Met Pro Gly Ser Pro Val Glu Val Lys Ile Gln Ser 
            20                  25                  30          


Arg Ser Ser Pro Pro Xaa Met Pro Pro Leu Pro Pro Ile Asn Pro Gly 
        35                  40                  45              


Gly Pro Arg Pro Val Ser Phe Xaa Pro Xaa Ala Leu Ser Asn Gly Ile 
    50                  55                  60                  


Asn His Ser Pro Pro Xaa Leu Asn Gly Ala Pro Ser Pro Pro Gln Arg 
65                  70                  75                  80  


Phe Ser Asn Gly Pro Ala Ser Ser Xaa Ser Ser Ala Leu Xaa Asn Gln 
                85                  90                  95      


Gln Leu Pro Ala Xaa Cys Gly Ala Arg Gln Leu Ser Lys Leu Lys Arg 
            100                 105                 110         


Phe Leu Xaa Xaa Leu Gln Gln Phe Gly Asn Asp Ile Ser Pro Glu Ile 
        115                 120                 125             


Gly Glu Lys Val Arg Xaa Leu Val Leu Ala Leu Val Asn Ser Xaa Val 
    130                 135                 140                 


Xaa Ile Glu Glu Phe His Cys Lys Leu Gln Glu Ala Xaa Asn Phe Pro 
145                 150                 155                 160 


Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala Asn Leu Pro Leu Leu 
                165                 170                 175     


Gln Arg Glu Leu Leu His Cys Ala Arg Ala Ala Lys Gln Xaa Pro Ser 
            180                 185                 190         


Gln Tyr Leu Ala Gln His Glu His Leu Leu Leu Asn Xaa Ser Ile Ala 
        195                 200                 205             


Ser Pro Ala Asp Ser Ser Glu Leu Leu Met Glu Val His Gly Asn Gly 
    210                 215                 220                 


Lys Arg Pro Ser Pro Glu Arg Arg Glu Glu Asn Ser Phe Asp Arg Asp 
225                 230                 235                 240 


Xaa Ile Ala Pro Glu Pro Pro Ala Lys Arg Val Cys Xaa Ile Ser Pro 
                245                 250                 255     


Ala Pro Arg His Ser Pro Ala Leu Xaa Val Pro Leu Met Asn Pro Gly 
            260                 265                 270         


Gly Gln Phe His Pro Xaa Pro Pro Pro Leu Gln His Tyr Xaa Leu Glu 
        275                 280                 285             


Asp Ile Ala Xaa Ser His Leu Tyr Arg Glu Pro Asn Lys Met Leu Glu 
    290                 295                 300                 


His Arg Glu Val Arg Asp Arg His His Ser Leu Gly Leu Asn Gly Gly 
305                 310                 315                 320 


Tyr Gln Asp Glu Leu Val Asp His Arg Leu Xaa Glu Arg Glu Trp Ala 
                325                 330                 335     


Asp Glu Trp Lys His Leu Asp His Ala Leu Asn Cys Ile Met Glu Met 
            340                 345                 350         


Val Glu Lys Xaa Arg Arg Ser Met Ala Val Leu Arg Arg Cys Gln Glu 
        355                 360                 365             


Ser Asp Arg Glu Glu Leu Asn Tyr Trp Lys Arg Arg Tyr Asn Glu Asn 
    370                 375                 380                 


Xaa Glu Leu Arg Lys Xaa Gly Xaa Glu Leu Val Ser Arg Gln His Ser 
385                 390                 395                 400 


Pro Gly Ser Ala Asp Ser Leu Ser Asn Asp Ser Gln Arg Glu Phe Asn 
                405                 410                 415     


Ser Arg Pro Gly Xaa Gly Tyr Val Pro Val Glu Phe Trp Lys Lys Xaa 
            420                 425                 430         


Glu Glu Ala Val Asn Lys Val Lys Ile Gln Ala Met Ser Glu Val Gln 
        435                 440                 445             


Lys Ala Val Ala Glu Ala Glu Gln Lys Ala Phe Glu Val Ile Ala Xaa 
    450                 455                 460                 


Glu Arg Ala Arg Met Glu Gln Xaa Ile Ala Asp Val Lys Arg Gln Ala 
465                 470                 475                 480 


Ala Glu Asp Ala Phe Leu Val Ile Asn Glu Gln Glu Glu Ser Xaa Glu 
                485                 490                 495     


Asn Cys Trp Asn Cys Gly Arg Lys Ala Ser Glu Xaa Cys Ser Gly Cys 
            500                 505                 510         


Asn Ile Ala Arg Tyr Cys Gly Ser Phe Cys Gln His Lys Asp Trp Glu 
        515                 520                 525             


Arg His His Arg Leu Cys Gly Gln Asn Leu His Gly Gln Ser Pro His 
    530                 535                 540                 


Gly Gln Gly Arg Pro Leu Leu Pro Val Gly Arg Gly Ser Ser Ala Arg 
545                 550                 555                 560 


Ser Ala Asp Cys Ser Val Pro Ser Pro Ala Leu Asp Lys Xaa Ser Ala 
                565                 570                 575     


Xaa Xaa Ser Arg Ser Ser Xaa Pro Ala Ser Val Xaa Ala Ile Asp Xaa 
            580                 585                 590         


Asn Gly Leu 
        595 


<210> 5112
<211> 653
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<400> 5112
Met Pro Ala Ser Arg Leu Arg Asp Arg Ala Ala Ser Ser Ala Ser Gly 
1               5                   10                  15      


Ser Xaa Cys Gly Ser Met Ser Gln Xaa His Pro Val Leu Glu Ser Gly 
            20                  25                  30          


Leu Leu Ala Ser Ala Gly Cys Ser Ala Pro Arg Gly Pro Arg Lys Gly 
        35                  40                  45              


Gly Pro Ala Pro Val Asp Arg Lys Ala Lys Ala Ser Ala Met Pro Asp 
    50                  55                  60                  


Ser Pro Ala Glu Val Lys Xaa Gln Pro Arg Ser Xaa Pro Pro Ser Met 
65                  70                  75                  80  


Pro Pro Pro Pro Pro Ala Ala Ser Gln Gly Ala Xaa Arg Pro Pro Ser 
                85                  90                  95      


Phe Xaa Pro His Xaa His Arg Glu Asp Gly Pro Ala Xaa Leu Pro His 
            100                 105                 110         


Gly Arg Phe His Gly Cys Leu Lys Trp Ser Met Val Cys Leu Leu Met 
        115                 120                 125             


Asn Gly Ser Ser His Ser Pro Xaa Ala Ile Asn Gly Ala Pro Cys Xaa 
    130                 135                 140                 


Pro Asn Gly Phe Ser Asn Gly Pro Ala Xaa Ser Ser Xaa Ala Ser Leu 
145                 150                 155                 160 


Ser Xaa Gln His Leu Pro Pro Ala Cys Gly Ala Arg Gln Leu Ser Lys 
                165                 170                 175     


Leu Lys Arg Phe Leu Xaa Xaa Leu Gln Gln Phe Gly Ser Asp Ile Ser 
            180                 185                 190         


Pro Glu Ile Gly Glu Arg Val Arg Xaa Leu Val Leu Gly Leu Val Asn 
        195                 200                 205             


Ser Xaa Leu Xaa Ile Glu Glu Phe His Ser Lys Leu Gln Glu Ala Xaa 
    210                 215                 220                 


Asn Phe Pro Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala Asn Leu 
225                 230                 235                 240 


Pro Leu Leu Gln Arg Glu Leu Leu His Cys Ala Arg Leu Ala Lys Gln 
                245                 250                 255     


Xaa Pro Ala Gln Tyr Leu Ala Gln His Glu Gln Leu Leu Leu Asp Ala 
            260                 265                 270         


Ser Ala Ser Ser Pro Ile Asp Ser Ser Glu Leu Leu Leu Glu Val Asn 
        275                 280                 285             


Glu Asn Gly Lys Arg Arg Xaa Pro Asp Arg Xaa Lys Glu Asn Gly Ser 
    290                 295                 300                 


Asp Arg Asp Pro Leu His Pro Glu His Leu Ser Lys Arg Pro Cys Xaa 
305                 310                 315                 320 


Leu Asn Pro Ala Gln Arg Tyr Ser Pro Ser Asn Gly Pro Pro Gln Pro 
                325                 330                 335     


Xaa Pro Pro Pro His Tyr Arg Leu Glu Asp Ile Ala Met Ala His His 
            340                 345                 350         


Phe Arg Asp Ala Tyr Arg His Pro Asp Pro Arg Glu Leu Arg Glu Arg 
        355                 360                 365             


His Arg Pro Leu Val Val Pro Gly Ser Arg Gln Glu Glu Val Ile Asp 
    370                 375                 380                 


His Lys Leu Xaa Glu Arg Glu Trp Ala Glu Glu Trp Lys His Leu Asn 
385                 390                 395                 400 


Asn Leu Leu Asn Cys Ile Met Asp Met Val Glu Lys Xaa Arg Arg Ser 
                405                 410                 415     


Leu Xaa Val Leu Arg Arg Cys Gln Glu Ala Asp Arg Glu Glu Leu Asn 
            420                 425                 430         


His Trp Ala Arg Arg Tyr Ser Asp Ala Glu Asp Xaa Lys Lys Gly Pro 
        435                 440                 445             


Ala Pro Ala Ala Ala Arg Pro Arg Ser Ser Ser Ala Gly Pro Glu Gly 
    450                 455                 460                 


Pro Gln Leu Asp Val Pro Arg Glu Phe Leu Pro Arg Xaa Leu Xaa Gly 
465                 470                 475                 480 


Tyr Val Pro Glu Asp Ile Trp Arg Lys Ala Glu Glu Ala Val Asn Glu 
                485                 490                 495     


Val Lys Arg Gln Ala Met Ser Glu Leu Gln Lys Ala Val Ser Asp Ala 
            500                 505                 510         


Glu Arg Lys Ala His Glu Leu Ile Xaa Xaa Glu Arg Ala Lys Met Glu 
        515                 520                 525             


Arg Ala Leu Ala Glu Ala Lys Arg Gln Ala Ser Glu Asp Ala Leu Xaa 
    530                 535                 540                 


Val Ile Asn Gln Gln Glu Asp Ser Ser Glu Ser Cys Trp Asn Cys Gly 
545                 550                 555                 560 


Arg Lys Ala Ser Glu Xaa Cys Ser Gly Cys Asn Ala Ala Arg Tyr Cys 
                565                 570                 575     


Gly Ser Phe Cys Gln His Arg Asp Trp Glu Lys His His His Val Cys 
            580                 585                 590         


Gly Gln Ser Leu Gln Gly Pro Xaa Ala Val Val Ala Asp Pro Val Pro 
        595                 600                 605             


Gly Pro Pro Glu Ala Ala His Ser Leu Gly Pro Ser Leu Pro Val Gly 
    610                 615                 620                 


Ala Ala Ser Pro Ser Glu Ala Gly Ser Ala Gly Pro Ser Arg Pro Gly 
625                 630                 635                 640 


Ser Pro Ser Pro Pro Gly Pro Leu Asp Xaa Val Pro Arg 
                645                 650             


<210> 5113
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 5113
Met Pro Ala Ser Arg Leu Arg Asp Arg Ala Ala Ser Ser Ala Ser Gly 
1               5                   10                  15      


Ser Xaa Cys Gly Ser Met Ser Gln Xaa His Pro Val Leu Glu Ser Gly 
            20                  25                  30          


Leu Leu Ala Ser Ala Gly Cys Ser Ala Pro Arg Gly Pro Arg Lys Gly 
        35                  40                  45              


Gly Pro Ala Pro Val Asp Arg Lys Ala Lys Ala Ser Ala Met Pro Asp 
    50                  55                  60                  


Ser Pro Ala Glu Val Lys Xaa Gln Pro Arg Ser Xaa Pro Pro Ser Met 
65                  70                  75                  80  


Pro Pro Pro Pro Pro Ala Ala Ser Gln Gly Ala Xaa Arg Pro Pro Ser 
                85                  90                  95      


Phe Xaa Pro His Xaa Leu Met Asn Gly Ser Ser His Ser Pro Xaa Ala 
            100                 105                 110         


Ile Asn Gly Ala Pro Cys Xaa Pro Asn Gly Phe Ser Asn Gly Pro Ala 
        115                 120                 125             


Xaa Ser 
    130 


<210> 5114
<211> 22
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<400> 5114
Met Pro Asp Ser Pro Ala Glu Val Lys Xaa Gln Pro Arg Ser Xaa Pro 
1               5                   10                  15      


Pro Ser Met Pro Pro Pro 
            20          


<210> 5115
<211> 62
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<400> 5115
Met Pro Asp Ser Pro Ala Glu Val Lys Xaa Gln Pro Arg Ser Xaa Pro 
1               5                   10                  15      


Pro Ser Met Pro Pro Pro Pro Pro Ala Ala Ser Gln Gly Ala Xaa Arg 
            20                  25                  30          


Pro Pro Ser Phe Xaa Pro His Xaa His Arg Glu Asp Gly Pro Ala Xaa 
        35                  40                  45              


Leu Pro His Gly Arg Phe His Gly Cys Leu Lys Trp Ser Met 
    50                  55                  60          


<210> 5116
<211> 132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(122)
<223> Selenocysteine

<400> 5116
Met Pro Asp Ser Pro Ala Glu Val Lys Xaa Gln Pro Arg Ser Xaa Pro 
1               5                   10                  15      


Pro Ser Met Pro Pro Pro Pro Pro Ala Ala Ser Gln Gly Ala Xaa Arg 
            20                  25                  30          


Pro Pro Ser Phe Xaa Pro His Xaa His Arg Glu Asp Gly Pro Ala Xaa 
        35                  40                  45              


Leu Pro His Gly Arg Phe His Gly Cys Leu Lys Trp Ser Met Val Cys 
    50                  55                  60                  


Leu Leu Met Asn Gly Ser Ser His Ser Pro Xaa Ala Ile Asn Gly Ala 
65                  70                  75                  80  


Pro Cys Xaa Pro Asn Gly Phe Ser Asn Gly Pro Ala Xaa Ser Ser Xaa 
                85                  90                  95      


Ala Ser Leu Ser Xaa Gln His Leu Pro Pro Ala Cys Gly Ala Arg Gln 
            100                 105                 110         


Leu Ser Lys Leu Lys Arg Phe Leu Xaa Xaa Leu Gln Gln Phe Gly Ser 
        115                 120                 125             


Asp Ile Ser Pro 
    130         


<210> 5117
<211> 419
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<400> 5117
Met Pro Asp Ser Pro Ala Glu Val Lys Xaa Gln Pro Arg Ser Xaa Pro 
1               5                   10                  15      


Pro Ser Met Pro Pro Pro Pro Pro Ala Ala Ser Gln Gly Ala Xaa Arg 
            20                  25                  30          


Pro Pro Ser Phe Xaa Pro His Xaa His Arg Glu Asp Gly Pro Ala Xaa 
        35                  40                  45              


Leu Pro His Gly Arg Phe His Gly Cys Leu Lys Trp Ser Met Val Cys 
    50                  55                  60                  


Leu Leu Met Asn Gly Ser Ser His Ser Pro Xaa Ala Ile Asn Gly Ala 
65                  70                  75                  80  


Pro Cys Xaa Pro Asn Gly Phe Ser Asn Gly Pro Ala Xaa Ser Ser Xaa 
                85                  90                  95      


Ala Ser Leu Ser Xaa Gln His Leu Pro Pro Ala Cys Gly Ala Arg Gln 
            100                 105                 110         


Leu Ser Lys Leu Lys Arg Phe Leu Xaa Xaa Leu Gln Gln Phe Gly Ser 
        115                 120                 125             


Asp Ile Ser Pro Glu Ile Gly Glu Arg Val Arg Xaa Leu Val Leu Gly 
    130                 135                 140                 


Leu Val Asn Ser Xaa Leu Xaa Ile Glu Glu Phe His Ser Lys Leu Gln 
145                 150                 155                 160 


Glu Ala Xaa Asn Phe Pro Leu Arg Pro Phe Val Ile Pro Phe Leu Lys 
                165                 170                 175     


Ala Asn Leu Pro Leu Leu Gln Arg Glu Leu Leu His Cys Ala Arg Leu 
            180                 185                 190         


Ala Lys Gln Xaa Pro Ala Gln Tyr Leu Ala Gln His Glu Gln Leu Leu 
        195                 200                 205             


Leu Asp Ala Ser Ala Ser Ser Pro Ile Asp Ser Ser Glu Leu Leu Leu 
    210                 215                 220                 


Glu Val Asn Glu Asn Gly Lys Arg Arg Xaa Pro Asp Arg Xaa Lys Glu 
225                 230                 235                 240 


Asn Gly Ser Asp Arg Asp Pro Leu His Pro Glu His Leu Ser Lys Arg 
                245                 250                 255     


Pro Cys Xaa Leu Asn Pro Ala Gln Arg Tyr Ser Pro Ser Asn Gly Pro 
            260                 265                 270         


Pro Gln Pro Xaa Pro Pro Pro His Tyr Arg Leu Glu Asp Ile Ala Met 
        275                 280                 285             


Ala His His Phe Arg Asp Ala Tyr Arg His Pro Asp Pro Arg Glu Leu 
    290                 295                 300                 


Arg Glu Arg His Arg Pro Leu Val Val Pro Gly Ser Arg Gln Glu Glu 
305                 310                 315                 320 


Val Ile Asp His Lys Leu Xaa Glu Arg Glu Trp Ala Glu Glu Trp Lys 
                325                 330                 335     


His Leu Asn Asn Leu Leu Asn Cys Ile Met Asp Met Val Glu Lys Xaa 
            340                 345                 350         


Arg Arg Ser Leu Xaa Val Leu Arg Arg Cys Gln Glu Ala Asp Arg Glu 
        355                 360                 365             


Glu Leu Asn His Trp Ala Arg Arg Tyr Ser Asp Ala Glu Asp Xaa Lys 
    370                 375                 380                 


Lys Gly Pro Ala Pro Ala Ala Ala Arg Pro Arg Ser Ser Ser Ala Gly 
385                 390                 395                 400 


Pro Glu Gly Pro Gln Leu Gly Lys His Gly Leu Val Cys Gln Glu Ala 
                405                 410                 415     


Trp Ser Ser 
            


<210> 5118
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 5118
Met Pro Asp Ser Pro Ala Glu Val Lys Xaa Gln Pro Arg Ser Xaa Pro 
1               5                   10                  15      


Pro Ser Met Pro Pro Pro Pro Pro Ala Ala Ser Gln Gly Ala Xaa Arg 
            20                  25                  30          


Pro Pro Ser Phe Xaa Pro His Xaa Leu Met Asn Gly Ser Ser His Ser 
        35                  40                  45              


Pro Xaa Ala Ile Asn Gly Ala Pro Cys Xaa Pro Asn Gly Phe Ser Asn 
    50                  55                  60                  


Gly Pro Ala Xaa Ser Ser Xaa Ala Ser Leu Ser Xaa Gln His Leu Pro 
65                  70                  75                  80  


Pro Ala Cys Gly Ala Arg Gln Leu Ser Lys Leu Lys Arg Phe Leu Xaa 
                85                  90                  95      


Xaa Leu Gln Gln Phe Gly Ser Asp Ile Ser Pro Glu Ile Gly Glu Arg 
            100                 105                 110         


Val Arg Xaa Leu Val Leu Gly Leu Val 
        115                 120     


<210> 5119
<211> 567
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<400> 5119
Met Pro Asp Ser Pro Ala Glu Val Lys Xaa Gln Pro Arg Ser Xaa Pro 
1               5                   10                  15      


Pro Ser Met Pro Pro Pro Pro Pro Ala Ala Ser Gln Gly Ala Xaa Arg 
            20                  25                  30          


Pro Pro Ser Phe Xaa Pro His Xaa Leu Met Asn Gly Ser Ser His Ser 
        35                  40                  45              


Pro Xaa Ala Ile Asn Gly Ala Pro Cys Xaa Pro Asn Gly Phe Ser Asn 
    50                  55                  60                  


Gly Pro Ala Xaa Ser Ser Xaa Ala Ser Leu Ser Xaa Gln His Leu Pro 
65                  70                  75                  80  


Pro Ala Cys Gly Ala Arg Gln Leu Ser Lys Leu Lys Arg Phe Leu Xaa 
                85                  90                  95      


Xaa Leu Gln Gln Phe Gly Ser Asp Ile Ser Pro Glu Ile Gly Glu Arg 
            100                 105                 110         


Val Arg Xaa Leu Val Leu Gly Leu Val Asn Ser Xaa Leu Xaa Ile Glu 
        115                 120                 125             


Glu Phe His Ser Lys Leu Gln Glu Ala Xaa Asn Phe Pro Leu Arg Pro 
    130                 135                 140                 


Phe Val Ile Pro Phe Leu Lys Ala Asn Leu Pro Leu Leu Gln Arg Glu 
145                 150                 155                 160 


Leu Leu His Cys Ala Arg Leu Ala Lys Gln Xaa Pro Ala Gln Tyr Leu 
                165                 170                 175     


Ala Gln His Glu Gln Leu Leu Leu Asp Ala Ser Ala Ser Ser Pro Ile 
            180                 185                 190         


Asp Ser Ser Glu Leu Leu Leu Glu Val Asn Glu Asn Gly Lys Arg Arg 
        195                 200                 205             


Xaa Pro Asp Arg Xaa Lys Glu Asn Gly Ser Asp Arg Asp Pro Leu His 
    210                 215                 220                 


Pro Glu His Leu Ser Lys Arg Pro Cys Xaa Leu Asn Pro Ala Gln Arg 
225                 230                 235                 240 


Tyr Ser Pro Ser Asn Gly Pro Pro Gln Pro Xaa Pro Pro Pro His Tyr 
                245                 250                 255     


Arg Leu Glu Asp Ile Ala Met Ala His His Phe Arg Asp Ala Tyr Arg 
            260                 265                 270         


His Pro Asp Pro Arg Glu Leu Arg Glu Arg His Arg Pro Leu Val Val 
        275                 280                 285             


Pro Gly Ser Arg Gln Glu Glu Val Ile Asp His Lys Leu Xaa Glu Arg 
    290                 295                 300                 


Glu Trp Ala Glu Glu Trp Lys His Leu Asn Asn Leu Leu Asn Cys Ile 
305                 310                 315                 320 


Met Asp Met Val Glu Lys Xaa Arg Arg Ser Leu Xaa Val Leu Arg Arg 
                325                 330                 335     


Cys Gln Glu Ala Asp Arg Glu Glu Leu Asn His Trp Ala Arg Arg Tyr 
            340                 345                 350         


Ser Asp Ala Glu Asp Xaa Lys Lys Gly Pro Ala Pro Ala Ala Ala Arg 
        355                 360                 365             


Pro Arg Ser Ser Ser Ala Gly Pro Glu Gly Pro Gln Leu Asp Val Pro 
    370                 375                 380                 


Arg Glu Phe Leu Pro Arg Xaa Leu Xaa Gly Tyr Val Pro Glu Asp Ile 
385                 390                 395                 400 


Trp Arg Lys Ala Glu Glu Ala Val Asn Glu Val Lys Arg Gln Ala Met 
                405                 410                 415     


Ser Glu Leu Gln Lys Ala Val Ser Asp Ala Glu Arg Lys Ala His Glu 
            420                 425                 430         


Leu Ile Xaa Xaa Glu Arg Ala Lys Met Glu Arg Ala Leu Ala Glu Ala 
        435                 440                 445             


Lys Arg Gln Ala Ser Glu Asp Ala Leu Xaa Val Ile Asn Gln Gln Glu 
    450                 455                 460                 


Asp Ser Ser Glu Ser Cys Trp Asn Cys Gly Arg Lys Ala Ser Glu Xaa 
465                 470                 475                 480 


Cys Ser Gly Cys Asn Ala Ala Arg Tyr Cys Gly Ser Phe Cys Gln His 
                485                 490                 495     


Arg Asp Trp Glu Lys His His His Val Cys Gly Gln Ser Leu Gln Gly 
            500                 505                 510         


Pro Xaa Ala Val Val Ala Asp Pro Val Pro Gly Pro Pro Glu Ala Ala 
        515                 520                 525             


His Ser Leu Gly Pro Ser Leu Pro Val Gly Ala Ala Ser Pro Ser Glu 
    530                 535                 540                 


Ala Gly Ser Ala Gly Pro Ser Arg Pro Gly Ser Pro Ser Pro Pro Gly 
545                 550                 555                 560 


Pro Leu Asp Xaa Val Pro Arg 
                565         


<210> 5120
<211> 34
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 5120
Xaa Gly Pro Glu Gly Pro Gln Leu Gly Lys His Gly Leu Val Cys Gln 
1               5                   10                  15      


Glu Ala Trp Ser Ser Glu Arg Leu Val Gly Gln Arg Leu Gly Ala Gly 
            20                  25                  30          


Arg Pro 
        


<210> 5121
<211> 61
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 5121
Met Ile Leu Asn Gly Val Cys Val Ile Trp Lys Gly Trp Ile Asp Leu 
1               5                   10                  15      


Gln Arg Leu Asp Gly Met Gly Cys Leu Glu Phe Asp Glu Glu Arg Ala 
            20                  25                  30          


Gln Gln Glu Asp Ala Leu Ala Gln Gln Ala Phe Glu Glu Ala Arg Arg 
        35                  40                  45              


Arg Xaa Arg Glu Phe Glu Asp Arg Asp Arg Ser His Arg 
    50                  55                  60      


<210> 5122
<211> 82
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<400> 5122
Met Ile Leu Asn Gly Val Cys Val Ile Trp Lys Gly Trp Ile Asp Leu 
1               5                   10                  15      


Gln Arg Leu Asp Gly Met Gly Cys Leu Glu Phe Asp Glu Glu Arg Ala 
            20                  25                  30          


Gln Gln Glu Asp Ala Leu Ala Gln Gln Ala Phe Glu Glu Ala Arg Arg 
        35                  40                  45              


Arg Xaa Arg Glu Phe Glu Asp Arg Asp Arg Ser His Arg Glu Glu Met 
    50                  55                  60                  


Glu Val Arg Val Ser Gln Leu Leu Ala Val Xaa Gly Lys Lys Xaa Xaa 
65                  70                  75                  80  


Arg Pro 
        


<210> 5123
<211> 187
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 5123
Met Pro Arg Val Val Pro Asp Gln Arg Ser Lys Phe Glu Asn Glu Glu 
1               5                   10                  15      


Phe Phe Arg Lys Leu Ser Arg Glu Cys Glu Ile Lys Tyr Xaa Gly Phe 
            20                  25                  30          


Arg Asp Arg Pro His Glu Glu Arg Gln Ala Arg Phe Gln Asn Ala Cys 
        35                  40                  45              


Arg Asp Gly Arg Ser Glu Ile Ala Phe Val Ala Xaa Gly Xaa Asn Leu 
    50                  55                  60                  


Ser Leu Gln Phe Phe Pro Ala Ser Trp Gln Gly Glu Gln Arg Gln Xaa 
65                  70                  75                  80  


Pro Ser Arg Glu Tyr Val Asp Leu Glu Arg Glu Ala Gly Lys Val Tyr 
                85                  90                  95      


Leu Lys Ala Pro Met Ile Leu Asn Gly Val Cys Val Ile Trp Lys Gly 
            100                 105                 110         


Trp Ile Asp Leu Gln Arg Leu Asp Gly Met Gly Cys Leu Glu Phe Asp 
        115                 120                 125             


Glu Glu Arg Ala Gln Gln Glu Asp Ala Leu Ala Gln Gln Ala Phe Glu 
    130                 135                 140                 


Glu Ala Arg Arg Arg Xaa Arg Glu Phe Glu Asp Arg Asp Arg Ser His 
145                 150                 155                 160 


Arg Glu Glu Met Glu Ala Arg Arg Gln Gln Asp Pro Ser Pro Gly Ser 
                165                 170                 175     


Asn Leu Gly Gly Gly Asp Asp Leu Lys Leu Arg 
            180                 185         


<210> 5124
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(180)
<223> Selenocysteine

<400> 5124
Met Pro Arg Val Val Pro Asp Gln Arg Ser Lys Phe Glu Asn Glu Glu 
1               5                   10                  15      


Phe Phe Arg Lys Leu Ser Arg Glu Cys Glu Ile Lys Tyr Xaa Gly Phe 
            20                  25                  30          


Arg Asp Arg Pro His Glu Glu Arg Gln Ala Arg Phe Gln Asn Ala Cys 
        35                  40                  45              


Arg Asp Gly Arg Ser Glu Ile Ala Phe Val Ala Xaa Gly Xaa Asn Leu 
    50                  55                  60                  


Ser Leu Gln Phe Phe Pro Ala Ser Trp Gln Gly Glu Gln Arg Gln Xaa 
65                  70                  75                  80  


Pro Ser Arg Glu Tyr Val Asp Leu Glu Arg Glu Ala Gly Lys Val Tyr 
                85                  90                  95      


Leu Lys Ala Pro Met Ile Leu Asn Gly Val Cys Val Ile Trp Lys Gly 
            100                 105                 110         


Trp Ile Asp Leu Gln Arg Leu Asp Gly Met Gly Cys Leu Glu Phe Asp 
        115                 120                 125             


Glu Glu Arg Ala Gln Gln Glu Asp Ala Leu Ala Gln Gln Ala Phe Glu 
    130                 135                 140                 


Glu Ala Arg Arg Arg Xaa Arg Glu Phe Glu Asp Arg Asp Arg Ser His 
145                 150                 155                 160 


Arg Glu Glu Met Glu Val Arg Val Ser Gln Leu Leu Ala Val Xaa Gly 
                165                 170                 175     


Lys Lys Xaa Xaa Arg Pro 
            180         


<210> 5125
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<400> 5125
Met Pro Arg Val Val Pro Asp Gln Arg Ser Lys Phe Glu Asn Glu Glu 
1               5                   10                  15      


Phe Phe Arg Lys Leu Ser Arg Glu Cys Glu Ile Lys Tyr Xaa Gly Phe 
            20                  25                  30          


Arg Asp Arg Pro His Glu Glu Arg Gln Ala Arg Phe Gln Asn Ala Cys 
        35                  40                  45              


Arg Asp Gly Arg Ser Glu Ile Val Tyr Leu Lys Ala Pro Met Ile Leu 
    50                  55                  60                  


Asn Gly Val Cys Val Ile Trp Lys Gly Trp Ile Asp Leu Gln Arg Leu 
65                  70                  75                  80  


Asp Gly Met Gly Cys Leu Glu Phe Asp Glu Glu Arg Ala 
                85                  90              


<210> 5126
<211> 60
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<400> 5126
Xaa Arg Lys Leu Ser Arg Glu Cys Glu Ile Lys Tyr Xaa Gly Phe Arg 
1               5                   10                  15      


Asp Arg Pro His Glu Glu Arg Gln Ala Arg Phe Gln Asn Ala Cys Arg 
            20                  25                  30          


Asp Gly Arg Ser Glu Ile Ala Arg Arg Gln Gln Asp Pro Ser Pro Gly 
        35                  40                  45              


Ser Asn Leu Gly Gly Gly Asp Asp Leu Lys Leu Arg 
    50                  55                  60  


<210> 5127
<211> 89
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<400> 5127
Ala Ala Ala His Ala Asn Xaa Gly Pro Glu Glu Ser Glu Asn Glu Asp 
1               5                   10                  15      


Asp Gly Tyr Asp Val Pro Lys Pro Pro Val Pro Ala Val Leu Ala Arg 
            20                  25                  30          


Arg Xaa Leu Ser Asp Ile Ser Asn Ala Ser Ser Ser Phe Gly Trp Leu 
        35                  40                  45              


Ser Leu Asp Gly Asp Pro Xaa Xaa Asn Val Xaa Glu Gly Ser Gln Val 
    50                  55                  60                  


Pro Glu Arg Pro Pro Lys Pro Phe Pro Arg Arg Ile Asn Ser Glu Arg 
65                  70                  75                  80  


Lys Ala Gly Ser Cys Gln Gln Val Ser 
                85                  


<210> 5128
<211> 869
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<400> 5128
Gly Asn Val Lys Lys Ser Ser Gly Ala Gly Gly Gly Ser Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Ser Gly Gly Leu Ile Gly Leu Met Lys Asp Ala Phe Gln 
            20                  25                  30          


Pro His His His His His His His Leu Ser Pro His Pro Pro Gly Xaa 
        35                  40                  45              


Val Asp Lys Lys Met Val Glu Lys Cys Trp Lys Leu Met Asp Lys Val 
    50                  55                  60                  


Val Arg Leu Cys Gln Asn Pro Lys Leu Ala Leu Lys Asn Ser Pro Pro 
65                  70                  75                  80  


Tyr Ile Leu Asp Leu Leu Pro Asp Xaa Tyr Gln His Leu Arg Xaa Ile 
                85                  90                  95      


Leu Ser Arg Tyr Glu Gly Lys Met Glu Xaa Leu Gly Glu Asn Glu Tyr 
            100                 105                 110         


Phe Arg Val Phe Met Glu Asn Leu Met Lys Lys Xaa Lys Gln Xaa Ile 
        115                 120                 125             


Ser Leu Phe Lys Glu Gly Lys Glu Arg Met Tyr Glu Glu Asn Ser Gln 
    130                 135                 140                 


Pro Arg Arg Asn Leu Xaa Lys Leu Ser Leu Ile Phe Ser His Met Leu 
145                 150                 155                 160 


Ala Glu Leu Lys Gly Ile Phe Pro Ser Gly Leu Phe Gln Gly Asp Xaa 
                165                 170                 175     


Phe Arg Ile Xaa Lys Ala Asp Ala Ala Glu Phe Trp Arg Lys Ala Phe 
            180                 185                 190         


Gly Glu Lys Xaa Ile Val Pro Trp Lys Ser Phe Arg Gln Ala Leu His 
        195                 200                 205             


Glu Val His Pro Ile Ser Ser Gly Leu Glu Ala Met Ala Leu Lys Ser 
    210                 215                 220                 


Xaa Ile Asp Leu Xaa Cys Asn Asp Tyr Ile Ser Val Phe Glu Phe Asp 
225                 230                 235                 240 


Ile Phe Xaa Arg Leu Phe Gln Pro Trp Ser Ser Leu Leu Arg Asn Trp 
                245                 250                 255     


Asn Ser Leu Ala Val Xaa His Pro Gly Tyr Met Ala Phe Leu Xaa Tyr 
            260                 265                 270         


Asp Glu Val Lys Ala Arg Leu Gln Lys Phe Ile His Lys Pro Gly Ser 
        275                 280                 285             


Tyr Ile Phe Arg Leu Ser Cys Xaa Arg Leu Gly Gln Trp Ala Ile Gly 
    290                 295                 300                 


Tyr Val Xaa Ala Asp Gly Asn Ile Leu Gln Xaa Ile Pro His Asn Lys 
305                 310                 315                 320 


Pro Leu Phe Gln Ala Leu Ile Asp Gly Phe Arg Glu Gly Phe Tyr Leu 
                325                 330                 335     


Phe Pro Asp Gly Arg Asn Gln Asn Pro Asp Leu Xaa Gly Leu Cys Glu 
            340                 345                 350         


Pro Xaa Pro Gln Asp His Ile Lys Val Xaa Gln Glu Gln Tyr Glu Leu 
        355                 360                 365             


Tyr Cys Glu Met Gly Ser Xaa Phe Gln Leu Cys Lys Ile Cys Ala Glu 
    370                 375                 380                 


Asn Asp Lys Asp Val Lys Ile Glu Pro Cys Gly His Leu Met Cys Xaa 
385                 390                 395                 400 


Ser Cys Leu Xaa Ser Trp Gln Glu Ser Glu Gly Gln Gly Cys Pro Phe 
                405                 410                 415     


Cys Arg Cys Glu Ile Lys Gly Xaa Glu Pro Ile Val Val Asp Pro Phe 
            420                 425                 430         


Asp Pro Arg Gly Ser Gly Ser Leu Leu Arg Gln Gly Ala Glu Gly Ala 
        435                 440                 445             


Pro Ser Pro Asn Tyr Asp Asp Asp Asp Asp Glu Arg Ala Asp Asp Xaa 
    450                 455                 460                 


Leu Phe Met Met Lys Glu Leu Ala Gly Ala Lys Val Glu Arg Pro Pro 
465                 470                 475                 480 


Ser Pro Phe Ser Met Ala Pro Gln Ala Ser Leu Pro Pro Val Pro Pro 
                485                 490                 495     


Arg Leu Asp Leu Leu Pro Gln Arg Val Cys Val Pro Ser Ser Ala Ser 
            500                 505                 510         


Ala Leu Gly Xaa Ala Ser Lys Ala Ala Ser Gly Ser Leu His Lys Asp 
        515                 520                 525             


Lys Pro Leu Pro Val Pro Pro Xaa Leu Arg Asp Leu Pro Pro Pro Pro 
    530                 535                 540                 


Pro Pro Asp Arg Pro Tyr Ser Val Gly Ala Glu Ser Arg Pro Gln Arg 
545                 550                 555                 560 


Arg Pro Leu Pro Cys Xaa Pro Gly Asp Cys Pro Ser Arg Asp Lys Leu 
                565                 570                 575     


Pro Pro Val Pro Ser Ser Arg Leu Gly Asp Ser Trp Leu Pro Arg Pro 
            580                 585                 590         


Ile Pro Lys Val Pro Val Ser Ala Pro Ser Ser Ser Asp Pro Trp Xaa 
        595                 600                 605             


Gly Arg Glu Leu Xaa Asn Arg His Ser Leu Pro Phe Ser Leu Pro Ser 
    610                 615                 620                 


Gln Met Glu Pro Arg Pro Asp Val Pro Arg Leu Gly Ser Xaa Phe Ser 
625                 630                 635                 640 


Leu Asp Xaa Ser Met Ser Met Asn Ser Ser Pro Leu Val Gly Pro Glu 
                645                 650                 655     


Cys Asp His Pro Lys Ile Lys Pro Ser Ser Ser Ala Asn Ala Ile Tyr 
            660                 665                 670         


Ser Leu Ala Ala Arg Pro Leu Pro Val Pro Lys Leu Pro Pro Gly Glu 
        675                 680                 685             


Gln Cys Glu Gly Glu Glu Asp Xaa Glu Tyr Met Xaa Pro Ser Ser Arg 
    690                 695                 700                 


Pro Leu Arg Pro Leu Asp Xaa Ser Gln Ser Ser Arg Ala Cys Asp Cys 
705                 710                 715                 720 


Asp Gln Gln Ile Asp Ser Cys Xaa Tyr Glu Ala Met Tyr Asn Ile Gln 
                725                 730                 735     


Ser Gln Ala Pro Ser Ile Xaa Glu Ser Ser Xaa Phe Gly Glu Gly Asn 
            740                 745                 750         


Leu Ala Ala Ala His Ala Asn Xaa Gly Pro Glu Glu Ser Glu Asn Glu 
        755                 760                 765             


Asp Asp Gly Tyr Asp Val Pro Lys Pro Pro Val Pro Ala Val Leu Ala 
    770                 775                 780                 


Arg Arg Xaa Leu Ser Asp Ile Ser Asn Ala Ser Ser Ser Phe Gly Trp 
785                 790                 795                 800 


Leu Ser Leu Asp Gly Asp Pro Xaa Xaa Asn Val Xaa Glu Gly Ser Gln 
                805                 810                 815     


Val Pro Glu Arg Pro Pro Lys Pro Phe Pro Arg Arg Ile Asn Ser Glu 
            820                 825                 830         


Arg Lys Ala Gly Ser Cys Gln Gln Asp Arg Val Ser Leu Leu Leu Pro 
        835                 840                 845             


Arg Leu Glu Cys Ser Gly Xaa Ile Ser Ala His Arg Asn Leu His Leu 
    850                 855                 860                 


Pro Pro Gly Phe Lys 
865                 


<210> 5129
<211> 862
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<400> 5129
Met Ala Gly Asn Val Lys Lys Ser Ser Gly Ala Gly Gly Gly Ser Gly 
1               5                   10                  15      


Ser Gly Gly Ser Gly Ser Gly Gly Leu Ile Gly Leu Met Lys Asp Ala 
            20                  25                  30          


Phe Gln Pro His His His His His His His Leu Ser Pro His Pro Pro 
        35                  40                  45              


Gly Xaa Val Asp Lys Lys Met Val Glu Lys Cys Trp Lys Leu Met Asp 
    50                  55                  60                  


Lys Val Val Arg Leu Cys Gln Asn Pro Lys Leu Ala Leu Lys Asn Ser 
65                  70                  75                  80  


Pro Pro Tyr Ile Leu Asp Leu Leu Pro Asp Xaa Tyr Gln His Leu Arg 
                85                  90                  95      


Xaa Ile Leu Ser Arg Tyr Glu Gly Lys Met Glu Xaa Leu Gly Glu Asn 
            100                 105                 110         


Glu Tyr Phe Arg Val Phe Met Glu Asn Leu Met Lys Lys Xaa Lys Gln 
        115                 120                 125             


Xaa Ile Ser Leu Phe Lys Glu Gly Lys Glu Arg Met Tyr Glu Glu Asn 
    130                 135                 140                 


Ser Gln Pro Arg Arg Asn Leu Xaa Lys Leu Ser Leu Ile Phe Ser His 
145                 150                 155                 160 


Met Leu Ala Glu Leu Lys Gly Ile Phe Pro Ser Gly Leu Phe Gln Gly 
                165                 170                 175     


Asp Xaa Phe Arg Ile Xaa Lys Ala Asp Ala Ala Glu Phe Trp Arg Lys 
            180                 185                 190         


Ala Phe Gly Glu Lys Xaa Ile Val Pro Trp Lys Ser Phe Arg Gln Ala 
        195                 200                 205             


Leu His Glu Val His Pro Ile Ser Ser Gly Leu Glu Ala Met Ala Leu 
    210                 215                 220                 


Lys Ser Xaa Ile Asp Leu Xaa Cys Asn Asp Tyr Ile Ser Val Phe Glu 
225                 230                 235                 240 


Phe Asp Ile Phe Xaa Arg Leu Phe Gln Pro Trp Ser Ser Leu Leu Arg 
                245                 250                 255     


Asn Trp Asn Ser Leu Ala Val Xaa His Pro Gly Tyr Met Ala Phe Leu 
            260                 265                 270         


Xaa Tyr Asp Glu Val Lys Ala Arg Leu Gln Lys Phe Ile His Lys Pro 
        275                 280                 285             


Gly Ser Tyr Ile Phe Arg Leu Ser Cys Xaa Arg Leu Gly Gln Trp Ala 
    290                 295                 300                 


Ile Gly Tyr Val Xaa Ala Asp Gly Asn Ile Leu Gln Xaa Ile Pro His 
305                 310                 315                 320 


Asn Lys Pro Leu Phe Gln Ala Leu Ile Asp Gly Phe Arg Glu Gly Phe 
                325                 330                 335     


Tyr Leu Phe Pro Asp Gly Arg Asn Gln Asn Pro Asp Leu Xaa Gly Leu 
            340                 345                 350         


Cys Glu Pro Xaa Pro Gln Asp His Ile Lys Val Xaa Gln Glu Gln Tyr 
        355                 360                 365             


Glu Leu Tyr Cys Glu Met Gly Ser Xaa Phe Gln Leu Cys Lys Ile Cys 
    370                 375                 380                 


Ala Glu Asn Asp Lys Asp Val Lys Ile Glu Pro Cys Gly His Leu Met 
385                 390                 395                 400 


Cys Xaa Ser Cys Leu Xaa Ser Trp Gln Glu Ser Glu Gly Gln Gly Cys 
                405                 410                 415     


Pro Phe Cys Arg Cys Glu Ile Lys Gly Xaa Glu Pro Ile Val Val Asp 
            420                 425                 430         


Pro Phe Asp Pro Arg Gly Ser Gly Ser Leu Leu Arg Gln Gly Ala Glu 
        435                 440                 445             


Gly Ala Pro Ser Pro Asn Tyr Asp Asp Asp Asp Asp Glu Arg Ala Asp 
    450                 455                 460                 


Asp Xaa Leu Phe Met Met Lys Glu Leu Ala Gly Ala Lys Ala Ala Ser 
465                 470                 475                 480 


Gly Ser Leu His Lys Asp Lys Pro Leu Pro Val Pro Pro Xaa Leu Arg 
                485                 490                 495     


Asp Leu Pro Pro Pro Pro Pro Pro Asp Arg Pro Tyr Ser Val Gly Ala 
            500                 505                 510         


Glu Ser Arg Pro Gln Arg Arg Pro Leu Pro Cys Xaa Pro Gly Asp Cys 
        515                 520                 525             


Pro Ser Arg Asp Lys Leu Pro Pro Val Pro Ser Ser Arg Leu Gly Asp 
    530                 535                 540                 


Ser Trp Leu Pro Arg Pro Ile Pro Lys Val Pro Val Ser Ala Pro Ser 
545                 550                 555                 560 


Ser Ser Asp Pro Trp Xaa Gly Arg Glu Leu Xaa Asn Arg His Ser Leu 
                565                 570                 575     


Pro Phe Ser Leu Pro Ser Gln Met Glu Pro Arg Pro Asp Val Pro Arg 
            580                 585                 590         


Leu Gly Ser Xaa Phe Ser Leu Asp Xaa Ser Met Ser Met Asn Ser Ser 
        595                 600                 605             


Pro Leu Val Gly Pro Glu Cys Asp His Pro Lys Ile Lys Pro Ser Ser 
    610                 615                 620                 


Ser Ala Asn Ala Ile Tyr Ser Leu Ala Ala Arg Pro Leu Pro Val Pro 
625                 630                 635                 640 


Lys Leu Pro Pro Gly Glu Gln Cys Glu Gly Glu Glu Asp Xaa Glu Tyr 
                645                 650                 655     


Met Xaa Pro Ser Ser Arg Pro Leu Arg Pro Leu Asp Xaa Ser Gln Ser 
            660                 665                 670         


Ser Arg Ala Cys Asp Cys Asp Gln Gln Ile Asp Ser Cys Xaa Tyr Glu 
        675                 680                 685             


Ala Met Tyr Asn Ile Gln Ser Gln Ala Pro Ser Ile Xaa Glu Ser Ser 
    690                 695                 700                 


Xaa Phe Gly Glu Gly Asn Leu Ala Ala Ala His Ala Asn Xaa Gly Pro 
705                 710                 715                 720 


Glu Glu Ser Glu Asn Glu Asp Asp Gly Tyr Asp Val Pro Lys Pro Pro 
                725                 730                 735     


Val Pro Ala Val Leu Ala Arg Arg Xaa Leu Ser Asp Ile Ser Asn Ala 
            740                 745                 750         


Ser Ser Ser Phe Gly Trp Leu Ser Leu Asp Gly Asp Pro Xaa Xaa Asn 
        755                 760                 765             


Val Xaa Glu Gly Ser Gln Val Pro Glu Arg Pro Pro Lys Pro Phe Pro 
    770                 775                 780                 


Arg Arg Ile Asn Ser Glu Arg Lys Ala Gly Ser Cys Gln Gln Gly Ser 
785                 790                 795                 800 


Gly Pro Ala Ala Ser Ala Ala Xaa Ala Ser Pro Gln Leu Ser Ser Glu 
                805                 810                 815     


Ile Glu Asn Leu Met Ser Gln Gly Tyr Ser Tyr Gln Asp Ile Gln Lys 
            820                 825                 830         


Ala Leu Val Ile Ala Gln Asn Asn Ile Glu Met Ala Lys Asn Ile Leu 
        835                 840                 845             


Arg Glu Phe Val Ser Ile Ser Ser Pro Ala His Val Ala Xaa 
    850                 855                 860         


<210> 5130
<211> 882
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<400> 5130
Met Ala Gly Asn Val Lys Lys Ser Ser Gly Ala Gly Gly Gly Ser Gly 
1               5                   10                  15      


Ser Gly Gly Ser Gly Ser Gly Gly Leu Ile Gly Leu Met Lys Asp Ala 
            20                  25                  30          


Phe Gln Pro His His His His His His His Leu Ser Pro His Pro Pro 
        35                  40                  45              


Gly Xaa Val Asp Lys Lys Met Val Glu Lys Cys Trp Lys Leu Met Asp 
    50                  55                  60                  


Lys Val Val Arg Leu Cys Gln Asn Pro Lys Leu Ala Leu Lys Asn Ser 
65                  70                  75                  80  


Pro Pro Tyr Ile Leu Asp Leu Leu Pro Asp Xaa Tyr Gln His Leu Arg 
                85                  90                  95      


Xaa Ile Leu Ser Arg Tyr Glu Gly Lys Met Glu Xaa Leu Gly Glu Asn 
            100                 105                 110         


Glu Tyr Phe Arg Val Phe Met Glu Asn Leu Met Lys Lys Xaa Lys Gln 
        115                 120                 125             


Xaa Ile Ser Leu Phe Lys Glu Gly Lys Glu Arg Met Tyr Glu Glu Asn 
    130                 135                 140                 


Ser Gln Pro Arg Arg Asn Leu Xaa Lys Leu Ser Leu Ile Phe Ser His 
145                 150                 155                 160 


Met Leu Ala Glu Leu Lys Gly Ile Phe Pro Ser Gly Leu Phe Gln Gly 
                165                 170                 175     


Asp Xaa Phe Arg Ile Xaa Lys Ala Asp Ala Ala Glu Phe Trp Arg Lys 
            180                 185                 190         


Ala Phe Gly Glu Lys Xaa Ile Val Pro Trp Lys Ser Phe Arg Gln Ala 
        195                 200                 205             


Leu His Glu Val His Pro Ile Ser Ser Gly Leu Glu Ala Met Ala Leu 
    210                 215                 220                 


Lys Ser Xaa Ile Asp Leu Xaa Cys Asn Asp Tyr Ile Ser Val Phe Glu 
225                 230                 235                 240 


Phe Asp Ile Phe Xaa Arg Leu Phe Gln Pro Trp Ser Ser Leu Leu Arg 
                245                 250                 255     


Asn Trp Asn Ser Leu Ala Val Xaa His Pro Gly Tyr Met Ala Phe Leu 
            260                 265                 270         


Xaa Tyr Asp Glu Val Lys Ala Arg Leu Gln Lys Phe Ile His Lys Pro 
        275                 280                 285             


Gly Ser Tyr Ile Phe Arg Leu Ser Cys Xaa Arg Leu Gly Gln Trp Ala 
    290                 295                 300                 


Ile Gly Tyr Val Xaa Ala Asp Gly Asn Ile Leu Gln Xaa Ile Pro His 
305                 310                 315                 320 


Asn Lys Pro Leu Phe Gln Ala Leu Ile Asp Gly Phe Arg Glu Gly Phe 
                325                 330                 335     


Tyr Leu Phe Pro Asp Gly Arg Asn Gln Asn Pro Asp Leu Xaa Gly Leu 
            340                 345                 350         


Cys Glu Pro Xaa Pro Gln Asp His Ile Lys Val Xaa Gln Glu Gln Tyr 
        355                 360                 365             


Glu Leu Tyr Cys Glu Met Gly Ser Xaa Phe Gln Leu Cys Lys Ile Cys 
    370                 375                 380                 


Ala Glu Asn Asp Lys Asp Val Lys Ile Glu Pro Cys Gly His Leu Met 
385                 390                 395                 400 


Cys Xaa Ser Cys Leu Xaa Ser Trp Gln Glu Ser Glu Gly Gln Gly Cys 
                405                 410                 415     


Pro Phe Cys Arg Cys Glu Ile Lys Gly Xaa Glu Pro Ile Val Val Asp 
            420                 425                 430         


Pro Phe Asp Pro Arg Gly Ser Gly Ser Leu Leu Arg Gln Gly Ala Glu 
        435                 440                 445             


Gly Ala Pro Ser Pro Asn Tyr Asp Asp Asp Asp Asp Glu Arg Ala Asp 
    450                 455                 460                 


Asp Xaa Leu Phe Met Met Lys Glu Leu Ala Gly Ala Lys Val Glu Arg 
465                 470                 475                 480 


Pro Pro Ser Pro Phe Ser Met Ala Pro Gln Ala Ser Leu Pro Pro Val 
                485                 490                 495     


Pro Pro Arg Leu Asp Leu Leu Pro Gln Arg Val Cys Val Pro Ser Ser 
            500                 505                 510         


Ala Ser Ala Leu Gly Xaa Ala Ser Lys Ala Ala Ser Gly Ser Leu His 
        515                 520                 525             


Lys Asp Lys Pro Leu Pro Val Pro Pro Xaa Leu Arg Asp Leu Pro Pro 
    530                 535                 540                 


Pro Pro Pro Pro Asp Arg Pro Tyr Ser Val Gly Ala Glu Ser Arg Pro 
545                 550                 555                 560 


Gln Arg Arg Pro Leu Pro Cys Xaa Pro Gly Asp Cys Pro Ser Arg Asp 
                565                 570                 575     


Lys Leu Pro Pro Val Pro Ser Ser Arg Leu Gly Asp Ser Trp Leu Pro 
            580                 585                 590         


Arg Pro Ile Pro Lys Val Pro Val Ser Ala Pro Ser Ser Ser Asp Pro 
        595                 600                 605             


Trp Xaa Gly Arg Glu Leu Xaa Asn Arg His Ser Leu Pro Phe Ser Leu 
    610                 615                 620                 


Pro Ser Gln Met Glu Pro Arg Pro Asp Val Pro Arg Leu Gly Ser Xaa 
625                 630                 635                 640 


Phe Ser Leu Asp Xaa Ser Met Ser Met Asn Ser Ser Pro Leu Val Gly 
                645                 650                 655     


Pro Glu Cys Asp His Pro Lys Ile Lys Pro Ser Ser Ser Ala Asn Ala 
            660                 665                 670         


Ile Tyr Ser Leu Ala Ala Arg Pro Leu Pro Val Pro Lys Leu Pro Pro 
        675                 680                 685             


Gly Glu Gln Cys Glu Gly Glu Glu Asp Xaa Glu Tyr Met Xaa Pro Ser 
    690                 695                 700                 


Ser Arg Pro Leu Arg Pro Leu Asp Xaa Ser Gln Ser Ser Arg Ala Cys 
705                 710                 715                 720 


Asp Cys Asp Gln Gln Ile Asp Ser Cys Xaa Tyr Glu Ala Met Tyr Asn 
                725                 730                 735     


Ile Gln Ser Gln Ala Pro Ser Ile Xaa Glu Ser Ser Xaa Phe Gly Glu 
            740                 745                 750         


Gly Asn Leu Ala Ala Ala His Ala Asn Xaa Gly Pro Glu Glu Ser Glu 
        755                 760                 765             


Asn Glu Asp Asp Gly Tyr Asp Val Pro Lys Pro Pro Val Pro Ala Val 
    770                 775                 780                 


Leu Ala Arg Arg Xaa Leu Ser Asp Ile Ser Asn Ala Ser Ser Ser Phe 
785                 790                 795                 800 


Gly Trp Leu Ser Leu Asp Gly Asp Pro Xaa Xaa Asn Val Xaa Glu Gly 
                805                 810                 815     


Ser Gln Val Pro Glu Arg Pro Pro Lys Pro Phe Pro Arg Arg Ile Asn 
            820                 825                 830         


Ser Glu Arg Lys Ala Gly Ser Cys Gln Gln Gly Ser Gly Pro Ala Ala 
        835                 840                 845             


Ser Ala Ala Xaa Ala Ser Pro Gln Leu Ser Lys Gln Ser Pro Lys Ala 
    850                 855                 860                 


Asn Leu Arg Ser Pro Asp Leu Ala Ala Glu Glu Ile Ser Arg Val Leu 
865                 870                 875                 880 


Ile Ala 
        


<210> 5131
<211> 906
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<400> 5131
Met Ala Gly Asn Val Lys Lys Ser Ser Gly Ala Gly Gly Gly Ser Gly 
1               5                   10                  15      


Ser Gly Gly Ser Gly Ser Gly Gly Leu Ile Gly Leu Met Lys Asp Ala 
            20                  25                  30          


Phe Gln Pro His His His His His His His Leu Ser Pro His Pro Pro 
        35                  40                  45              


Gly Xaa Val Asp Lys Lys Met Val Glu Lys Cys Trp Lys Leu Met Asp 
    50                  55                  60                  


Lys Val Val Arg Leu Cys Gln Asn Pro Lys Leu Ala Leu Lys Asn Ser 
65                  70                  75                  80  


Pro Pro Tyr Ile Leu Asp Leu Leu Pro Asp Xaa Tyr Gln His Leu Arg 
                85                  90                  95      


Xaa Ile Leu Ser Arg Tyr Glu Gly Lys Met Glu Xaa Leu Gly Glu Asn 
            100                 105                 110         


Glu Tyr Phe Arg Val Phe Met Glu Asn Leu Met Lys Lys Xaa Lys Gln 
        115                 120                 125             


Xaa Ile Ser Leu Phe Lys Glu Gly Lys Glu Arg Met Tyr Glu Glu Asn 
    130                 135                 140                 


Ser Gln Pro Arg Arg Asn Leu Xaa Lys Leu Ser Leu Ile Phe Ser His 
145                 150                 155                 160 


Met Leu Ala Glu Leu Lys Gly Ile Phe Pro Ser Gly Leu Phe Gln Gly 
                165                 170                 175     


Asp Xaa Phe Arg Ile Xaa Lys Ala Asp Ala Ala Glu Phe Trp Arg Lys 
            180                 185                 190         


Ala Phe Gly Glu Lys Xaa Ile Val Pro Trp Lys Ser Phe Arg Gln Ala 
        195                 200                 205             


Leu His Glu Val His Pro Ile Ser Ser Gly Leu Glu Ala Met Ala Leu 
    210                 215                 220                 


Lys Ser Xaa Ile Asp Leu Xaa Cys Asn Asp Tyr Ile Ser Val Phe Glu 
225                 230                 235                 240 


Phe Asp Ile Phe Xaa Arg Leu Phe Gln Pro Trp Ser Ser Leu Leu Arg 
                245                 250                 255     


Asn Trp Asn Ser Leu Ala Val Xaa His Pro Gly Tyr Met Ala Phe Leu 
            260                 265                 270         


Xaa Tyr Asp Glu Val Lys Ala Arg Leu Gln Lys Phe Ile His Lys Pro 
        275                 280                 285             


Gly Ser Tyr Ile Phe Arg Leu Ser Cys Xaa Arg Leu Gly Gln Trp Ala 
    290                 295                 300                 


Ile Gly Tyr Val Xaa Ala Asp Gly Asn Ile Leu Gln Xaa Ile Pro His 
305                 310                 315                 320 


Asn Lys Pro Leu Phe Gln Ala Leu Ile Asp Gly Phe Arg Glu Gly Phe 
                325                 330                 335     


Tyr Leu Phe Pro Asp Gly Arg Asn Gln Asn Pro Asp Leu Xaa Gly Leu 
            340                 345                 350         


Cys Glu Pro Xaa Pro Gln Asp His Ile Lys Val Xaa Gln Glu Gln Tyr 
        355                 360                 365             


Glu Leu Tyr Cys Glu Met Gly Ser Xaa Phe Gln Leu Cys Lys Ile Cys 
    370                 375                 380                 


Ala Glu Asn Asp Lys Asp Val Lys Ile Glu Pro Cys Gly His Leu Met 
385                 390                 395                 400 


Cys Xaa Ser Cys Leu Xaa Ser Trp Gln Glu Ser Glu Gly Gln Gly Cys 
                405                 410                 415     


Pro Phe Cys Arg Cys Glu Ile Lys Gly Xaa Glu Pro Ile Val Val Asp 
            420                 425                 430         


Pro Phe Asp Pro Arg Gly Ser Gly Ser Leu Leu Arg Gln Gly Ala Glu 
        435                 440                 445             


Gly Ala Pro Ser Pro Asn Tyr Asp Asp Asp Asp Asp Glu Arg Ala Asp 
    450                 455                 460                 


Asp Xaa Leu Phe Met Met Lys Glu Leu Ala Gly Ala Lys Val Glu Arg 
465                 470                 475                 480 


Pro Pro Ser Pro Phe Ser Met Ala Pro Gln Ala Ser Leu Pro Pro Val 
                485                 490                 495     


Pro Pro Arg Leu Asp Leu Leu Pro Gln Arg Val Cys Val Pro Ser Ser 
            500                 505                 510         


Ala Ser Ala Leu Gly Xaa Ala Ser Lys Ala Ala Ser Gly Ser Leu His 
        515                 520                 525             


Lys Asp Lys Pro Leu Pro Val Pro Pro Xaa Leu Arg Asp Leu Pro Pro 
    530                 535                 540                 


Pro Pro Pro Pro Asp Arg Pro Tyr Ser Val Gly Ala Glu Ser Arg Pro 
545                 550                 555                 560 


Gln Arg Arg Pro Leu Pro Cys Xaa Pro Gly Asp Cys Pro Ser Arg Asp 
                565                 570                 575     


Lys Leu Pro Pro Val Pro Ser Ser Arg Leu Gly Asp Ser Trp Leu Pro 
            580                 585                 590         


Arg Pro Ile Pro Lys Val Pro Val Ser Ala Pro Ser Ser Ser Asp Pro 
        595                 600                 605             


Trp Xaa Gly Arg Glu Leu Xaa Asn Arg His Ser Leu Pro Phe Ser Leu 
    610                 615                 620                 


Pro Ser Gln Met Glu Pro Arg Pro Asp Val Pro Arg Leu Gly Ser Xaa 
625                 630                 635                 640 


Phe Ser Leu Asp Xaa Ser Met Ser Met Asn Ser Ser Pro Leu Val Gly 
                645                 650                 655     


Pro Glu Cys Asp His Pro Lys Ile Lys Pro Ser Ser Ser Ala Asn Ala 
            660                 665                 670         


Ile Tyr Ser Leu Ala Ala Arg Pro Leu Pro Val Pro Lys Leu Pro Pro 
        675                 680                 685             


Gly Glu Gln Cys Glu Gly Glu Glu Asp Xaa Glu Tyr Met Xaa Pro Ser 
    690                 695                 700                 


Ser Arg Pro Leu Arg Pro Leu Asp Xaa Ser Gln Ser Ser Arg Ala Cys 
705                 710                 715                 720 


Asp Cys Asp Gln Gln Ile Asp Ser Cys Xaa Tyr Glu Ala Met Tyr Asn 
                725                 730                 735     


Ile Gln Ser Gln Ala Pro Ser Ile Xaa Glu Ser Ser Xaa Phe Gly Glu 
            740                 745                 750         


Gly Asn Leu Ala Ala Ala His Ala Asn Xaa Gly Pro Glu Glu Ser Glu 
        755                 760                 765             


Asn Glu Asp Asp Gly Tyr Asp Val Pro Lys Pro Pro Val Pro Ala Val 
    770                 775                 780                 


Leu Ala Arg Arg Xaa Leu Ser Asp Ile Ser Asn Ala Ser Ser Ser Phe 
785                 790                 795                 800 


Gly Trp Leu Ser Leu Asp Gly Asp Pro Xaa Xaa Asn Val Xaa Glu Gly 
                805                 810                 815     


Ser Gln Val Pro Glu Arg Pro Pro Lys Pro Phe Pro Arg Arg Ile Asn 
            820                 825                 830         


Ser Glu Arg Lys Ala Gly Ser Cys Gln Gln Gly Ser Gly Pro Ala Ala 
        835                 840                 845             


Ser Ala Ala Xaa Ala Ser Pro Gln Leu Ser Ser Glu Ile Glu Asn Leu 
    850                 855                 860                 


Met Ser Gln Gly Tyr Ser Tyr Gln Asp Ile Gln Lys Ala Leu Val Ile 
865                 870                 875                 880 


Ala Gln Asn Asn Ile Glu Met Ala Lys Asn Ile Leu Arg Glu Phe Val 
                885                 890                 895     


Ser Ile Ser Ser Pro Ala His Val Ala Xaa 
            900                 905     


<210> 5132
<211> 321
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<400> 5132
Gly Ile Xaa Ala Ser Ser Asn Val Asn Gly Arg His Ser Arg Val Gly 
1               5                   10                  15      


Ser Asp Pro Val Leu Met Arg Lys His Arg Arg His Asp Leu Pro Leu 
            20                  25                  30          


Glu Gly Ala Lys Val Phe Ser Asn Gly His Leu Gly Ser Glu Glu Tyr 
        35                  40                  45              


Asp Val Pro Pro Arg Leu Ser Pro Pro Pro Pro Val Xaa Xaa Leu Leu 
    50                  55                  60                  


Pro Ser Ile Lys Cys Xaa Gly Pro Leu Ala Asn Ser Leu Ser Glu Lys 
65                  70                  75                  80  


Xaa Arg Asp Pro Val Glu Glu Asp Asp Asp Glu Tyr Lys Ile Pro Ser 
                85                  90                  95      


Ser His Pro Val Ser Leu Asn Ser Gln Pro Ser His Cys His Asn Val 
            100                 105                 110         


Lys Pro Pro Val Arg Ser Cys Asp Asn Gly His Cys Met Leu Asn Gly 
        115                 120                 125             


Xaa His Gly Pro Ser Ser Glu Lys Lys Ser Asn Ile Pro Asp Leu Ser 
    130                 135                 140                 


Ile Tyr Leu Lys Gly Glu Asp Ala Phe Asp Ala Leu Pro Pro Ser Leu 
145                 150                 155                 160 


Pro Pro Pro Pro Pro Pro Ala Arg His Ser Leu Ile Glu His Ser Lys 
                165                 170                 175     


Pro Pro Gly Ser Ser Ser Arg Pro Ser Ser Gly Gln Asp Leu Phe Leu 
            180                 185                 190         


Leu Pro Ser Asp Pro Phe Val Asp Leu Ala Ser Gly Gln Val Pro Leu 
        195                 200                 205             


Pro Pro Ala Arg Arg Leu Pro Gly Glu Asn Val Lys Xaa Asn Arg Xaa 
    210                 215                 220                 


Ser Gln Asp Tyr Asp Gln Leu Pro Ser Cys Ser Asp Gly Ser Gln Ala 
225                 230                 235                 240 


Pro Ala Arg Pro Pro Lys Pro Arg Pro Arg Arg Xaa Ala Pro Glu Ile 
                245                 250                 255     


His His Arg Lys Pro His Gly Pro Glu Ala Ala Leu Glu Asn Val Asp 
            260                 265                 270         


Ala Lys Ile Ala Lys Leu Met Gly Glu Gly Tyr Ala Phe Glu Glu Val 
        275                 280                 285             


Lys Arg Ala Leu Glu Ile Ala Gln Asn Asn Val Glu Val Ala Arg Ser 
    290                 295                 300                 


Ile Leu Arg Glu Phe Ala Phe Pro Pro Pro Val Ser Pro Arg Leu Asn 
305                 310                 315                 320 


Leu 
    


<210> 5133
<211> 161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 5133
Met Ala Leu Ala Pro Gly Pro Asp Ala His Ala His Leu Pro Pro Leu 
1               5                   10                  15      


Ile Glu Leu Lys Phe Gln Met Ala Asn Ser Met Asn Gly Arg Asn Pro 
            20                  25                  30          


Gly Gly Arg Gly Gly Asn Pro Arg Lys Gly Arg Ile Leu Gly Ile Ile 
        35                  40                  45              


Asp Ala Ile Gln Asp Ala Val Gly Pro Pro Lys Gln Ala Ala Ala Asp 
    50                  55                  60                  


Arg Arg Xaa Val Glu Lys Xaa Trp Lys Leu Met Asp Lys Val Val Arg 
65                  70                  75                  80  


Leu Cys Gln Asn Pro Lys Leu Gln Leu Lys Asn Ser Pro Pro Tyr Ile 
                85                  90                  95      


Leu Asp Ile Leu Pro Asp Xaa Tyr Gln His Leu Arg Leu Ile Leu Ser 
            100                 105                 110         


Lys Tyr Asp Asp Asn Gln Lys Leu Ala Gln Leu Ser Glu Asn Glu Tyr 
        115                 120                 125             


Phe Lys Ile Tyr Ile Asp Ser Leu Met Lys Lys Ser Lys Arg Ala Ile 
    130                 135                 140                 


Arg Leu Phe Lys Glu Gly Lys Glu Arg Met Tyr Glu Glu Gln Ser Gln 
145                 150                 155                 160 


Asp 
    


<210> 5134
<211> 139
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 5134
Met Ala Asn Ser Met Asn Gly Arg Asn Pro Gly Gly Arg Gly Gly Asn 
1               5                   10                  15      


Pro Arg Lys Gly Arg Ile Leu Gly Ile Ile Asp Ala Ile Gln Asp Ala 
            20                  25                  30          


Val Gly Pro Pro Lys Gln Ala Ala Ala Asp Arg Arg Xaa Val Glu Lys 
        35                  40                  45              


Xaa Trp Lys Leu Met Asp Lys Val Val Arg Leu Cys Gln Asn Pro Lys 
    50                  55                  60                  


Leu Gln Leu Lys Asn Ser Pro Pro Tyr Ile Leu Asp Ile Leu Pro Asp 
65                  70                  75                  80  


Xaa Tyr Gln His Leu Arg Leu Ile Leu Ser Lys Tyr Asp Asp Asn Gln 
                85                  90                  95      


Lys Leu Ala Gln Leu Ser Glu Asn Glu Tyr Phe Lys Ile Tyr Ile Asp 
            100                 105                 110         


Ser Leu Met Lys Lys Ser Lys Arg Ala Ile Arg Leu Phe Lys Glu Gly 
        115                 120                 125             


Lys Glu Arg Met Tyr Glu Glu Gln Ser Gln Asp 
    130                 135                 


<210> 5135
<211> 770
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<400> 5135
Met Ala Asn Ser Met Asn Gly Arg Asn Pro Gly Gly Arg Gly Gly Asn 
1               5                   10                  15      


Pro Arg Lys Gly Arg Ile Leu Gly Ile Ile Asp Ala Ile Gln Asp Ala 
            20                  25                  30          


Val Gly Pro Pro Lys Gln Ala Ala Ala Asp Arg Arg Xaa Val Glu Lys 
        35                  40                  45              


Xaa Trp Lys Leu Met Asp Lys Val Val Arg Leu Cys Gln Asn Pro Lys 
    50                  55                  60                  


Leu Gln Leu Lys Asn Ser Pro Pro Tyr Ile Leu Asp Ile Leu Pro Asp 
65                  70                  75                  80  


Xaa Tyr Gln His Leu Arg Leu Ile Leu Ser Lys Tyr Asp Asp Asn Gln 
                85                  90                  95      


Lys Leu Ala Gln Leu Ser Glu Asn Glu Tyr Phe Lys Ile Tyr Ile Asp 
            100                 105                 110         


Ser Leu Met Lys Lys Ser Lys Arg Ala Ile Arg Leu Phe Lys Glu Gly 
        115                 120                 125             


Lys Glu Arg Met Tyr Glu Glu Gln Ser Gln Asp Arg Arg Asn Leu Xaa 
    130                 135                 140                 


Lys Leu Ser Leu Ile Phe Ser His Met Leu Ala Glu Ile Lys Ala Ile 
145                 150                 155                 160 


Phe Pro Asn Gly Gln Phe Gln Gly Asp Asn Phe Arg Ile Xaa Lys Ala 
                165                 170                 175     


Asp Ala Ala Glu Phe Trp Arg Lys Phe Phe Gly Asp Lys Xaa Ile Val 
            180                 185                 190         


Pro Trp Lys Val Phe Arg Gln Cys Leu His Glu Val His Gln Ile Ser 
        195                 200                 205             


Ser Gly Leu Glu Ala Met Ala Leu Lys Ser Xaa Ile Asp Leu Xaa Cys 
    210                 215                 220                 


Asn Asp Tyr Ile Ser Val Phe Glu Phe Asp Ile Phe Xaa Arg Leu Phe 
225                 230                 235                 240 


Gln Pro Trp Gly Ser Ile Leu Arg Asn Trp Asn Phe Leu Ala Val Xaa 
                245                 250                 255     


His Pro Gly Tyr Met Ala Phe Leu Xaa Tyr Asp Glu Val Lys Ala Arg 
            260                 265                 270         


Leu Gln Lys Tyr Ser Xaa Lys Pro Gly Ser Tyr Ile Phe Arg Leu Ser 
        275                 280                 285             


Cys Xaa Arg Leu Gly Gln Trp Ala Ile Gly Tyr Val Xaa Gly Asp Gly 
    290                 295                 300                 


Asn Ile Leu Gln Xaa Ile Pro His Asn Lys Pro Leu Phe Gln Ala Leu 
305                 310                 315                 320 


Ile Asp Gly Ser Arg Glu Gly Phe Tyr Leu Tyr Pro Asp Gly Arg Ser 
                325                 330                 335     


Tyr Asn Pro Asp Leu Xaa Gly Leu Cys Glu Pro Xaa Pro His Asp His 
            340                 345                 350         


Ile Lys Val Xaa Gln Glu Gln Tyr Glu Leu Tyr Cys Glu Met Gly Ser 
        355                 360                 365             


Xaa Phe Gln Leu Cys Lys Ile Cys Ala Glu Asn Asp Lys Asp Val Lys 
    370                 375                 380                 


Ile Glu Pro Cys Gly His Leu Met Cys Xaa Ser Cys Leu Xaa Ala Trp 
385                 390                 395                 400 


Gln Glu Ser Asp Gly Gln Gly Cys Pro Phe Cys Arg Cys Glu Ile Lys 
                405                 410                 415     


Gly Xaa Glu Pro Ile Ile Val Asp Pro Phe Asp Pro Arg Asp Glu Gly 
            420                 425                 430         


Ser Arg Cys Cys Ser Ile Ile Asp Pro Phe Gly Met Pro Met Leu Asp 
        435                 440                 445             


Leu Asp Asp Asp Asp Asp Arg Glu Glu Ser Leu Met Met Asn Arg Leu 
    450                 455                 460                 


Ala Asn Val Arg Lys Cys Xaa Asp Arg Gln Asn Ser Pro Val Xaa Ser 
465                 470                 475                 480 


Pro Gly Ser Ser Pro Leu Ala Gln Arg Arg Lys Pro Gln Pro Asp Pro 
                485                 490                 495     


Leu Gln Ile Pro His Leu Ser Leu Pro Pro Val Pro Pro Arg Leu Asp 
            500                 505                 510         


Leu Ile Gln Lys Gly Ile Val Arg Ser Pro Cys Gly Ser Pro Xaa Gly 
        515                 520                 525             


Ser Pro Lys Ser Ser Pro Cys Met Val Arg Lys Gln Asp Lys Pro Leu 
    530                 535                 540                 


Pro Ala Pro Pro Pro Pro Leu Arg Asp Pro Pro Pro Pro Pro Pro Glu 
545                 550                 555                 560 


Arg Pro Pro Pro Ile Pro Pro Asp Asn Arg Leu Ser Arg His Ile His 
                565                 570                 575     


His Val Glu Ser Val Pro Ser Arg Asp Pro Pro Met Pro Leu Glu Ala 
            580                 585                 590         


Trp Cys Pro Arg Asp Val Phe Gly Xaa Asn Gln Leu Val Gly Cys Arg 
        595                 600                 605             


Leu Leu Gly Glu Gly Ser Pro Lys Pro Gly Ile Xaa Ala Ser Ser Asn 
    610                 615                 620                 


Val Asn Gly Arg His Ser Arg Val Gly Ser Asp Pro Val Leu Met Arg 
625                 630                 635                 640 


Lys His Arg Arg His Asp Leu Pro Leu Glu Gly Ala Lys Val Phe Ser 
                645                 650                 655     


Asn Gly His Leu Gly Ser Glu Glu Tyr Asp Val Pro Pro Arg Leu Ser 
            660                 665                 670         


Pro Pro Pro Pro Val Xaa Xaa Leu Leu Pro Ser Ile Lys Cys Xaa Gly 
        675                 680                 685             


Pro Leu Ala Asn Ser Leu Ser Glu Lys Xaa Arg Asp Pro Val Glu Glu 
    690                 695                 700                 


Asp Asp Asp Glu Tyr Lys Ile Pro Ser Ser His Pro Val Ser Leu Asn 
705                 710                 715                 720 


Ser Gln Pro Ser His Cys His Asn Val Lys Pro Pro Val Arg Ser Cys 
                725                 730                 735     


Asp Asn Gly His Cys Met Leu Asn Gly Xaa His Gly Pro Ser Ser Glu 
            740                 745                 750         


Lys Lys Ser Asn Ile Pro Asp Leu Ser Ile Tyr Leu Lys Gly Xaa Tyr 
        755                 760                 765             


Arg Ile 
    770 


<210> 5136
<211> 810
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<400> 5136
Met Ala Asn Ser Met Asn Gly Arg Asn Pro Gly Gly Arg Gly Gly Asn 
1               5                   10                  15      


Pro Arg Lys Gly Arg Ile Leu Gly Ile Ile Asp Ala Ile Gln Asp Ala 
            20                  25                  30          


Val Gly Pro Pro Lys Gln Ala Ala Ala Asp Arg Arg Xaa Val Glu Lys 
        35                  40                  45              


Xaa Trp Lys Leu Met Asp Lys Val Val Arg Leu Cys Gln Asn Pro Lys 
    50                  55                  60                  


Leu Gln Leu Lys Asn Ser Pro Pro Tyr Ile Leu Asp Ile Leu Pro Asp 
65                  70                  75                  80  


Xaa Tyr Gln His Leu Arg Leu Ile Leu Ser Lys Tyr Asp Asp Asn Gln 
                85                  90                  95      


Lys Leu Ala Gln Leu Ser Glu Asn Glu Tyr Phe Lys Ile Tyr Ile Asp 
            100                 105                 110         


Ser Leu Met Lys Lys Ser Lys Arg Ala Ile Arg Leu Phe Lys Glu Gly 
        115                 120                 125             


Lys Glu Arg Met Tyr Glu Glu Gln Ser Gln Asp Arg Arg Asn Leu Xaa 
    130                 135                 140                 


Lys Leu Ser Leu Ile Phe Ser His Met Leu Ala Glu Ile Lys Ala Ile 
145                 150                 155                 160 


Phe Pro Asn Gly Gln Phe Gln Gly Asp Asn Phe Arg Ile Xaa Lys Ala 
                165                 170                 175     


Asp Ala Ala Glu Phe Trp Arg Lys Phe Phe Gly Asp Lys Xaa Ile Val 
            180                 185                 190         


Pro Trp Lys Val Phe Arg Gln Cys Leu His Glu Val His Gln Ile Ser 
        195                 200                 205             


Ser Gly Leu Glu Ala Met Ala Leu Lys Ser Xaa Ile Asp Leu Xaa Cys 
    210                 215                 220                 


Asn Asp Tyr Ile Ser Val Phe Glu Phe Asp Ile Phe Xaa Arg Leu Phe 
225                 230                 235                 240 


Gln Pro Trp Gly Ser Ile Leu Arg Asn Trp Asn Phe Leu Ala Val Xaa 
                245                 250                 255     


His Pro Gly Tyr Met Ala Phe Leu Xaa Tyr Asp Glu Val Lys Ala Arg 
            260                 265                 270         


Leu Gln Lys Tyr Ser Xaa Lys Pro Gly Ser Tyr Ile Phe Arg Leu Ser 
        275                 280                 285             


Cys Xaa Arg Leu Gly Gln Trp Ala Ile Gly Tyr Val Xaa Gly Asp Gly 
    290                 295                 300                 


Asn Ile Leu Gln Xaa Ile Pro His Asn Lys Pro Leu Phe Gln Ala Leu 
305                 310                 315                 320 


Ile Asp Gly Ser Arg Glu Gly Phe Tyr Leu Tyr Pro Asp Gly Arg Ser 
                325                 330                 335     


Tyr Asn Pro Asp Leu Xaa Gly Leu Cys Glu Pro Xaa Pro His Asp His 
            340                 345                 350         


Ile Lys Val Xaa Gln Glu Gln Tyr Glu Leu Tyr Cys Glu Met Gly Ser 
        355                 360                 365             


Xaa Phe Gln Leu Cys Lys Ile Cys Ala Glu Asn Asp Lys Asp Val Lys 
    370                 375                 380                 


Ile Glu Pro Cys Gly His Leu Met Cys Xaa Ser Cys Leu Xaa Ala Trp 
385                 390                 395                 400 


Gln Glu Ser Asp Gly Gln Gly Cys Pro Phe Cys Arg Cys Glu Ile Lys 
                405                 410                 415     


Gly Xaa Glu Pro Ile Ile Val Asp Pro Phe Asp Pro Arg Asp Glu Gly 
            420                 425                 430         


Ser Arg Cys Cys Ser Ile Ile Asp Pro Phe Gly Met Pro Met Leu Asp 
        435                 440                 445             


Leu Asp Asp Asp Asp Asp Arg Glu Glu Ser Leu Met Met Asn Arg Leu 
    450                 455                 460                 


Ala Asn Val Arg Lys Cys Xaa Asp Arg Gln Asn Ser Pro Val Xaa Ser 
465                 470                 475                 480 


Pro Gly Ser Ser Pro Leu Ala Gln Arg Arg Lys Pro Gln Pro Asp Pro 
                485                 490                 495     


Leu Gln Ile Pro His Leu Ser Leu Pro Pro Val Pro Pro Arg Leu Asp 
            500                 505                 510         


Leu Ile Gln Lys Gly Ile Val Arg Ser Pro Cys Gly Ser Pro Xaa Gly 
        515                 520                 525             


Ser Pro Lys Ser Ser Pro Cys Met Val Arg Lys Gln Asp Lys Pro Leu 
    530                 535                 540                 


Pro Ala Pro Pro Pro Pro Leu Arg Asp Pro Pro Pro Pro Pro Pro Glu 
545                 550                 555                 560 


Arg Pro Pro Pro Ile Pro Pro Asp Asn Arg Leu Ser Arg His Ile His 
                565                 570                 575     


His Val Glu Ser Val Pro Ser Arg Asp Pro Pro Met Pro Leu Glu Ala 
            580                 585                 590         


Trp Cys Pro Arg Asp Val Phe Gly Xaa Asn Gln Leu Val Gly Cys Arg 
        595                 600                 605             


Leu Leu Gly Glu Gly Ser Pro Lys Pro Gly Ile Xaa Ala Ser Ser Asn 
    610                 615                 620                 


Val Asn Gly Arg His Ser Arg Val Gly Ser Asp Pro Val Leu Met Arg 
625                 630                 635                 640 


Lys His Arg Arg His Asp Leu Pro Leu Glu Gly Ala Lys Val Phe Ser 
                645                 650                 655     


Asn Gly His Leu Gly Ser Glu Glu Tyr Asp Val Pro Pro Arg Leu Ser 
            660                 665                 670         


Pro Pro Pro Pro Val Xaa Xaa Leu Leu Pro Ser Ile Lys Cys Xaa Gly 
        675                 680                 685             


Pro Leu Ala Asn Ser Leu Ser Glu Lys Xaa Arg Asp Pro Val Glu Glu 
    690                 695                 700                 


Asp Asp Asp Glu Tyr Lys Ile Pro Ser Ser His Pro Val Ser Leu Asn 
705                 710                 715                 720 


Ser Gln Pro Ser His Cys His Asn Val Lys Pro Pro Val Arg Ser Cys 
                725                 730                 735     


Asp Asn Gly His Cys Met Leu Asn Gly Xaa His Gly Pro Ser Ser Glu 
            740                 745                 750         


Lys Lys Ser Asn Ile Pro Asp Leu Ser Ile Tyr Leu Lys Gly Asp Val 
        755                 760                 765             


Phe Asp Ser Ala Ser Asp Pro Val Pro Leu Pro Pro Ala Arg Pro Pro 
    770                 775                 780                 


Xaa Arg Asp Asn Pro Lys His Gly Ser Ser Leu Asn Arg Xaa Pro Ser 
785                 790                 795                 800 


Asp Tyr Asp Leu Leu Ile Pro Pro Leu Gly 
                805                 810 


<210> 5137
<211> 982
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<400> 5137
Met Ala Asn Ser Met Asn Gly Arg Asn Pro Gly Gly Arg Gly Gly Asn 
1               5                   10                  15      


Pro Arg Lys Gly Arg Ile Leu Gly Ile Ile Asp Ala Ile Gln Asp Ala 
            20                  25                  30          


Val Gly Pro Pro Lys Gln Ala Ala Ala Asp Arg Arg Xaa Val Glu Lys 
        35                  40                  45              


Xaa Trp Lys Leu Met Asp Lys Val Val Arg Leu Cys Gln Asn Pro Lys 
    50                  55                  60                  


Leu Gln Leu Lys Asn Ser Pro Pro Tyr Ile Leu Asp Ile Leu Pro Asp 
65                  70                  75                  80  


Xaa Tyr Gln His Leu Arg Leu Ile Leu Ser Lys Tyr Asp Asp Asn Gln 
                85                  90                  95      


Lys Leu Ala Gln Leu Ser Glu Asn Glu Tyr Phe Lys Ile Tyr Ile Asp 
            100                 105                 110         


Ser Leu Met Lys Lys Ser Lys Arg Ala Ile Arg Leu Phe Lys Glu Gly 
        115                 120                 125             


Lys Glu Arg Met Tyr Glu Glu Gln Ser Gln Asp Arg Arg Asn Leu Xaa 
    130                 135                 140                 


Lys Leu Ser Leu Ile Phe Ser His Met Leu Ala Glu Ile Lys Ala Ile 
145                 150                 155                 160 


Phe Pro Asn Gly Gln Phe Gln Gly Asp Asn Phe Arg Ile Xaa Lys Ala 
                165                 170                 175     


Asp Ala Ala Glu Phe Trp Arg Lys Phe Phe Gly Asp Lys Xaa Ile Val 
            180                 185                 190         


Pro Trp Lys Val Phe Arg Gln Cys Leu His Glu Val His Gln Ile Ser 
        195                 200                 205             


Ser Gly Leu Glu Ala Met Ala Leu Lys Ser Xaa Ile Asp Leu Xaa Cys 
    210                 215                 220                 


Asn Asp Tyr Ile Ser Val Phe Glu Phe Asp Ile Phe Xaa Arg Leu Phe 
225                 230                 235                 240 


Gln Pro Trp Gly Ser Ile Leu Arg Asn Trp Asn Phe Leu Ala Val Xaa 
                245                 250                 255     


His Pro Gly Tyr Met Ala Phe Leu Xaa Tyr Asp Glu Val Lys Ala Arg 
            260                 265                 270         


Leu Gln Lys Tyr Ser Xaa Lys Pro Gly Ser Tyr Ile Phe Arg Leu Ser 
        275                 280                 285             


Cys Xaa Arg Leu Gly Gln Trp Ala Ile Gly Tyr Val Xaa Gly Asp Gly 
    290                 295                 300                 


Asn Ile Leu Gln Xaa Ile Pro His Asn Lys Pro Leu Phe Gln Ala Leu 
305                 310                 315                 320 


Ile Asp Gly Ser Arg Glu Gly Phe Tyr Leu Tyr Pro Asp Gly Arg Ser 
                325                 330                 335     


Tyr Asn Pro Asp Leu Xaa Gly Leu Cys Glu Pro Xaa Pro His Asp His 
            340                 345                 350         


Ile Lys Val Xaa Gln Glu Gln Tyr Glu Leu Tyr Cys Glu Met Gly Ser 
        355                 360                 365             


Xaa Phe Gln Leu Cys Lys Ile Cys Ala Glu Asn Asp Lys Asp Val Lys 
    370                 375                 380                 


Ile Glu Pro Cys Gly His Leu Met Cys Xaa Ser Cys Leu Xaa Ala Trp 
385                 390                 395                 400 


Gln Glu Ser Asp Gly Gln Gly Cys Pro Phe Cys Arg Cys Glu Ile Lys 
                405                 410                 415     


Gly Xaa Glu Pro Ile Ile Val Asp Pro Phe Asp Pro Arg Asp Glu Gly 
            420                 425                 430         


Ser Arg Cys Cys Ser Ile Ile Asp Pro Phe Gly Met Pro Met Leu Asp 
        435                 440                 445             


Leu Asp Asp Asp Asp Asp Arg Glu Glu Ser Leu Met Met Asn Arg Leu 
    450                 455                 460                 


Ala Asn Val Arg Lys Cys Xaa Asp Arg Gln Asn Ser Pro Val Xaa Ser 
465                 470                 475                 480 


Pro Gly Ser Ser Pro Leu Ala Gln Arg Arg Lys Pro Gln Pro Asp Pro 
                485                 490                 495     


Leu Gln Ile Pro His Leu Ser Leu Pro Pro Val Pro Pro Arg Leu Asp 
            500                 505                 510         


Leu Ile Gln Lys Gly Ile Val Arg Ser Pro Cys Gly Ser Pro Xaa Gly 
        515                 520                 525             


Ser Pro Lys Ser Ser Pro Cys Met Val Arg Lys Gln Asp Lys Pro Leu 
    530                 535                 540                 


Pro Ala Pro Pro Pro Pro Leu Arg Asp Pro Pro Pro Pro Pro Pro Glu 
545                 550                 555                 560 


Arg Pro Pro Pro Ile Pro Pro Asp Asn Arg Leu Ser Arg His Ile His 
                565                 570                 575     


His Val Glu Ser Val Pro Ser Arg Asp Pro Pro Met Pro Leu Glu Ala 
            580                 585                 590         


Trp Cys Pro Arg Asp Val Phe Gly Xaa Asn Gln Leu Val Gly Cys Arg 
        595                 600                 605             


Leu Leu Gly Glu Gly Ser Pro Lys Pro Gly Ile Xaa Ala Ser Ser Asn 
    610                 615                 620                 


Val Asn Gly Arg His Ser Arg Val Gly Ser Asp Pro Val Leu Met Arg 
625                 630                 635                 640 


Lys His Arg Arg His Asp Leu Pro Leu Glu Gly Ala Lys Val Phe Ser 
                645                 650                 655     


Asn Gly His Leu Gly Ser Glu Glu Tyr Asp Val Pro Pro Arg Leu Ser 
            660                 665                 670         


Pro Pro Pro Pro Val Xaa Xaa Leu Leu Pro Ser Ile Lys Cys Xaa Gly 
        675                 680                 685             


Pro Leu Ala Asn Ser Leu Ser Glu Lys Xaa Arg Asp Pro Val Glu Glu 
    690                 695                 700                 


Asp Asp Asp Glu Tyr Lys Ile Pro Ser Ser His Pro Val Ser Leu Asn 
705                 710                 715                 720 


Ser Gln Pro Ser His Cys His Asn Val Lys Pro Pro Val Arg Ser Cys 
                725                 730                 735     


Asp Asn Gly His Cys Met Leu Asn Gly Xaa His Gly Pro Ser Ser Glu 
            740                 745                 750         


Lys Lys Ser Asn Ile Pro Asp Leu Ser Ile Tyr Leu Lys Gly Asp Val 
        755                 760                 765             


Phe Asp Ser Ala Ser Asp Pro Val Pro Leu Pro Pro Ala Arg Pro Pro 
    770                 775                 780                 


Xaa Arg Asp Asn Pro Lys His Gly Ser Ser Leu Asn Arg Xaa Pro Ser 
785                 790                 795                 800 


Asp Tyr Asp Leu Leu Ile Pro Pro Leu Gly Glu Asp Ala Phe Asp Ala 
                805                 810                 815     


Leu Pro Pro Ser Leu Pro Pro Pro Pro Pro Pro Ala Arg His Ser Leu 
            820                 825                 830         


Ile Glu His Ser Lys Pro Pro Gly Ser Ser Ser Arg Pro Ser Ser Gly 
        835                 840                 845             


Gln Asp Leu Phe Leu Leu Pro Ser Asp Pro Phe Val Asp Leu Ala Ser 
    850                 855                 860                 


Gly Gln Val Pro Leu Pro Pro Ala Arg Arg Leu Pro Gly Glu Asn Val 
865                 870                 875                 880 


Lys Xaa Asn Arg Xaa Ser Gln Asp Tyr Asp Gln Leu Pro Ser Cys Ser 
                885                 890                 895     


Asp Gly Ser Gln Ala Pro Ala Arg Pro Pro Lys Pro Arg Pro Arg Arg 
            900                 905                 910         


Xaa Ala Pro Glu Ile His His Arg Lys Pro His Gly Pro Glu Ala Ala 
        915                 920                 925             


Leu Glu Asn Val Asp Ala Lys Ile Ala Lys Leu Met Gly Glu Gly Tyr 
    930                 935                 940                 


Ala Phe Glu Glu Val Lys Arg Ala Leu Glu Ile Ala Gln Asn Asn Val 
945                 950                 955                 960 


Glu Val Ala Arg Ser Ile Leu Arg Glu Phe Ala Phe Pro Pro Pro Val 
                965                 970                 975     


Ser Pro Arg Leu Asn Leu 
            980         


<210> 5138
<211> 197
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 5138
Met Leu Asn Gly Xaa His Gly Pro Ser Ser Glu Lys Lys Ser Asn Ile 
1               5                   10                  15      


Pro Asp Leu Ser Ile Tyr Leu Lys Gly Glu Asp Ala Phe Asp Ala Leu 
            20                  25                  30          


Pro Pro Ser Leu Pro Pro Pro Pro Pro Pro Ala Arg His Ser Leu Ile 
        35                  40                  45              


Glu His Ser Lys Pro Pro Gly Ser Ser Ser Arg Pro Ser Ser Gly Gln 
    50                  55                  60                  


Asp Leu Phe Leu Leu Pro Ser Asp Pro Phe Val Asp Leu Ala Ser Gly 
65                  70                  75                  80  


Gln Val Pro Leu Pro Pro Ala Arg Arg Leu Pro Gly Glu Asn Val Lys 
                85                  90                  95      


Xaa Asn Arg Xaa Ser Gln Asp Tyr Asp Gln Leu Pro Ser Cys Ser Asp 
            100                 105                 110         


Gly Ser Gln Ala Pro Ala Arg Pro Pro Lys Pro Arg Pro Arg Arg Xaa 
        115                 120                 125             


Ala Pro Glu Ile His His Arg Lys Pro His Gly Pro Glu Ala Ala Leu 
    130                 135                 140                 


Glu Asn Val Asp Ala Lys Ile Ala Lys Leu Met Gly Glu Gly Tyr Ala 
145                 150                 155                 160 


Phe Glu Glu Val Lys Arg Ala Leu Glu Ile Ala Gln Asn Asn Val Glu 
                165                 170                 175     


Val Ala Arg Ser Ile Leu Arg Glu Phe Ala Phe Pro Pro Pro Val Ser 
            180                 185                 190         


Pro Arg Leu Asn Leu 
        195         


<210> 5139
<211> 428
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<400> 5139
Met Ala Leu Ala Val Ala Pro Trp Gly Arg Gln Trp Glu Glu Ala Arg 
1               5                   10                  15      


Ala Leu Gly Arg Ala Val Arg Met Leu Gln Arg Leu Glu Glu Gln Cys 
            20                  25                  30          


Val Asp Pro Arg Leu Ser Val Ser Pro Pro Ser Leu Arg Asp Leu Leu 
        35                  40                  45              


Pro Arg Xaa Ala Gln Leu Leu Arg Glu Val Ala His Ser Arg Arg Ala 
    50                  55                  60                  


Ala Gly Gly Gly Gly Pro Gly Gly Pro Gly Gly Ser Gly Asp Phe Leu 
65                  70                  75                  80  


Leu Ile Tyr Leu Ala Asn Leu Glu Ala Lys Ser Arg Gln Val Ala Ala 
                85                  90                  95      


Leu Leu Pro Pro Arg Gly Arg Arg Ser Ala Asn Asp Glu Leu Phe Arg 
            100                 105                 110         


Ala Gly Ser Arg Leu Arg Arg Gln Leu Ala Lys Leu Ala Ile Ile Phe 
        115                 120                 125             


Ser His Met His Ala Glu Leu His Ala Leu Phe Pro Gly Gly Lys Tyr 
    130                 135                 140                 


Cys Gly His Met Tyr Gln Leu Xaa Lys Ala Pro Ala His Xaa Phe Trp 
145                 150                 155                 160 


Arg Glu Ser Cys Gly Ala Arg Cys Val Leu Pro Trp Ala Glu Phe Glu 
                165                 170                 175     


Ser Leu Leu Gly Xaa Cys His Pro Val Glu Pro Gly Cys Xaa Ala Leu 
            180                 185                 190         


Ala Leu Arg Xaa Xaa Ile Asp Leu Xaa Cys Ser Gly His Val Ser Ile 
        195                 200                 205             


Phe Glu Phe Asp Val Phe Xaa Arg Leu Phe Gln Pro Trp Pro Xaa Leu 
    210                 215                 220                 


Leu Lys Asn Trp Gln Leu Leu Ala Val Asn His Pro Gly Tyr Met Ala 
225                 230                 235                 240 


Phe Leu Xaa Tyr Asp Glu Val Gln Glu Arg Leu Gln Ala Cys Arg Asp 
                245                 250                 255     


Lys Pro Gly Ser Tyr Leu Tyr Pro Asp Gly Lys Xaa His Asn Pro Asp 
            260                 265                 270         


Leu Xaa Glu Leu Gly Gln Ala Glu Pro Gln Gln Arg Ile His Val Ser 
        275                 280                 285             


Glu Glu Gln Leu Gln Leu Tyr Trp Ala Met Asp Ser Xaa Phe Glu Leu 
    290                 295                 300                 


Cys Lys Ile Cys Ala Glu Ser Asn Lys Asp Val Lys Ile Glu Pro Cys 
305                 310                 315                 320 


Gly His Leu Leu Cys Ser Cys Cys Leu Ala Ala Trp Gln His Ser Asp 
                325                 330                 335     


Ser Gln Xaa Cys Pro Phe Cys Arg Cys Glu Ile Lys Gly Trp Glu Ala 
            340                 345                 350         


Val Ser Ile Tyr Gln Phe His Gly Gln Ala Xaa Ala Glu Asp Ser Gly 
        355                 360                 365             


Asn Ser Ser Asp Gln Glu Gly Arg Glu Leu Glu Leu Gly Gln Val Pro 
    370                 375                 380                 


Leu Ser Ala Pro Pro Leu Pro Pro Arg Pro Asp Leu Pro Pro Arg Lys 
385                 390                 395                 400 


Pro Arg Asn Ala Gln Pro Lys Val Arg Leu Leu Lys Gly Asn Ser Pro 
                405                 410                 415     


Pro Ala Ala Leu Gly Pro Gln Asp Pro Ala Pro Ala 
            420                 425             


<210> 5140
<211> 474
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<400> 5140
Met Ala Leu Ala Val Ala Pro Trp Gly Arg Gln Trp Glu Glu Ala Arg 
1               5                   10                  15      


Ala Leu Gly Arg Ala Val Arg Met Leu Gln Arg Leu Glu Glu Gln Cys 
            20                  25                  30          


Val Asp Pro Arg Leu Ser Val Ser Pro Pro Ser Leu Arg Asp Leu Leu 
        35                  40                  45              


Pro Arg Xaa Ala Gln Leu Leu Arg Glu Val Ala His Ser Arg Arg Ala 
    50                  55                  60                  


Ala Gly Gly Gly Gly Pro Gly Gly Pro Gly Gly Ser Gly Asp Phe Leu 
65                  70                  75                  80  


Leu Ile Tyr Leu Ala Asn Leu Glu Ala Lys Ser Arg Gln Val Ala Ala 
                85                  90                  95      


Leu Leu Pro Pro Arg Gly Arg Arg Ser Ala Asn Asp Glu Leu Phe Arg 
            100                 105                 110         


Ala Gly Ser Arg Leu Arg Arg Gln Leu Ala Lys Leu Ala Ile Ile Phe 
        115                 120                 125             


Ser His Met His Ala Glu Leu His Ala Leu Phe Pro Gly Gly Lys Tyr 
    130                 135                 140                 


Cys Gly His Met Tyr Gln Leu Xaa Lys Ala Pro Ala His Xaa Phe Trp 
145                 150                 155                 160 


Arg Glu Ser Cys Gly Ala Arg Cys Val Leu Pro Trp Ala Glu Phe Glu 
                165                 170                 175     


Ser Leu Leu Gly Xaa Cys His Pro Val Glu Pro Gly Cys Xaa Ala Leu 
            180                 185                 190         


Ala Leu Arg Xaa Xaa Ile Asp Leu Xaa Cys Ser Gly His Val Ser Ile 
        195                 200                 205             


Phe Glu Phe Asp Val Phe Xaa Arg Leu Phe Gln Pro Trp Pro Xaa Leu 
    210                 215                 220                 


Leu Lys Asn Trp Gln Leu Leu Ala Val Asn His Pro Gly Tyr Met Ala 
225                 230                 235                 240 


Phe Leu Xaa Tyr Asp Glu Val Gln Glu Arg Leu Gln Ala Cys Arg Asp 
                245                 250                 255     


Lys Pro Gly Ser Tyr Ile Phe Arg Pro Ser Cys Xaa Arg Leu Gly Gln 
            260                 265                 270         


Trp Ala Ile Gly Tyr Val Ser Ser Asp Gly Ser Ile Leu Gln Xaa Ile 
        275                 280                 285             


Pro Ala Asn Lys Pro Leu Ser Gln Val Leu Leu Glu Gly Gln Lys Asp 
    290                 295                 300                 


Gly Phe Tyr Leu Tyr Pro Asp Gly Lys Xaa His Asn Pro Asp Leu Xaa 
305                 310                 315                 320 


Glu Leu Gly Gln Ala Glu Pro Gln Gln Arg Ile His Val Ser Glu Glu 
                325                 330                 335     


Gln Leu Gln Leu Tyr Trp Ala Met Asp Ser Xaa Phe Glu Leu Cys Lys 
            340                 345                 350         


Ile Cys Ala Glu Ser Asn Lys Asp Val Lys Ile Glu Pro Cys Gly His 
        355                 360                 365             


Leu Leu Cys Ser Cys Cys Leu Ala Ala Trp Gln His Ser Asp Ser Gln 
    370                 375                 380                 


Xaa Cys Pro Phe Cys Arg Cys Glu Ile Lys Gly Trp Glu Ala Val Ser 
385                 390                 395                 400 


Ile Tyr Gln Phe His Gly Gln Ala Xaa Ala Glu Asp Ser Gly Asn Ser 
                405                 410                 415     


Ser Asp Gln Glu Gly Arg Glu Leu Glu Leu Gly Gln Val Pro Leu Ser 
            420                 425                 430         


Ala Pro Pro Leu Pro Pro Arg Pro Asp Leu Pro Pro Arg Lys Pro Arg 
        435                 440                 445             


Asn Ala Gln Pro Lys Val Arg Leu Leu Lys Gly Asn Ser Pro Pro Ala 
    450                 455                 460                 


Ala Leu Gly Pro Gln Asp Pro Ala Pro Ala 
465                 470                 


<210> 5141
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<400> 5141
Met Gly Lys Lys Gln Asn Lys Lys Lys Val Glu Glu Val Leu Glu Glu 
1               5                   10                  15      


Glu Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val 
            20                  25                  30          


Lys Gly Lys Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Asp Glu 
        35                  40                  45              


Asp Asn Xaa Trp Glu Pro Glu Glu Asn Leu Asp Cys Pro Asp Leu Ile 
    50                  55                  60                  


Ala Glu Phe Leu Gln Ser Gln Lys Xaa Ala His Glu Xaa Asp Lys Ser 
65                  70                  75                  80  


Glu Gly Gly Lys Arg Lys Ala Asp Ser Asp Ser Glu Asp Lys Gly Glu 
                85                  90                  95      


Glu Ser Lys Pro Lys Lys Lys Lys Glu Glu Ser Glu Lys Pro 
            100                 105                 110 


<210> 5142
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<400> 5142
Met Gly Lys Lys Gln Asn Lys Lys Lys Val Glu Glu Val Leu Glu Glu 
1               5                   10                  15      


Glu Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val 
            20                  25                  30          


Lys Gly Lys Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Asp Glu 
        35                  40                  45              


Asp Asn Xaa Trp Glu Pro Glu Glu Asn Leu Asp Cys Pro Asp Leu Ile 
    50                  55                  60                  


Ala Glu Phe Leu Gln Ser Gln Lys Xaa Ala His Glu Xaa Asp Lys Ser 
65                  70                  75                  80  


Glu Gly Gly Lys Arg Lys Ala Asp Ser Asp Ser Glu Asp Lys Gly Glu 
                85                  90                  95      


Glu Ser Lys Pro Lys Lys Lys Lys Glu Glu Ser Glu Lys Pro Arg Gly 
            100                 105                 110         


Phe Ala Arg Gly Leu Glu Pro Glu Arg Ile Ile Gly Ala Xaa Asp Ser 
        115                 120                 125             


Ser Gly Glu Leu Met Phe Leu Met Lys Trp 
    130                 135             


<210> 5143
<211> 173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 5143
Met Gly Lys Lys Gln Asn Lys Lys Lys Val Glu Glu Val Leu Glu Glu 
1               5                   10                  15      


Glu Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val 
            20                  25                  30          


Lys Gly Lys Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Asp Glu 
        35                  40                  45              


Asp Asn Xaa Trp Glu Pro Glu Glu Asn Leu Asp Cys Pro Asp Leu Ile 
    50                  55                  60                  


Ala Glu Phe Leu Gln Ser Gln Lys Xaa Ala His Glu Xaa Asp Lys Ser 
65                  70                  75                  80  


Glu Gly Gly Lys Arg Lys Ala Asp Ser Asp Ser Glu Asp Lys Gly Glu 
                85                  90                  95      


Glu Ser Lys Pro Lys Lys Lys Lys Glu Glu Ser Glu Lys Pro Arg Gly 
            100                 105                 110         


Phe Ala Arg Gly Leu Glu Pro Glu Arg Ile Ile Gly Ala Xaa Asp Ser 
        115                 120                 125             


Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asn Ser Asp Glu Ala 
    130                 135                 140                 


Asp Leu Val Pro Ala Lys Glu Ala Asn Val Lys Cys Pro Gln Val Val 
145                 150                 155                 160 


Ile Ser Phe Tyr Glu Glu Arg Leu Xaa Trp His Ser Tyr 
                165                 170             


<210> 5144
<211> 185
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 5144
Met Gly Lys Lys Gln Asn Lys Lys Lys Val Glu Glu Val Leu Glu Glu 
1               5                   10                  15      


Glu Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val 
            20                  25                  30          


Lys Gly Lys Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Asp Glu 
        35                  40                  45              


Asp Asn Xaa Trp Glu Pro Glu Glu Asn Leu Asp Cys Pro Asp Leu Ile 
    50                  55                  60                  


Ala Glu Phe Leu Gln Ser Gln Lys Xaa Ala His Glu Xaa Asp Lys Ser 
65                  70                  75                  80  


Glu Gly Gly Lys Arg Lys Ala Asp Ser Asp Ser Glu Asp Lys Gly Glu 
                85                  90                  95      


Glu Ser Lys Pro Lys Lys Lys Lys Glu Glu Ser Glu Lys Pro Arg Gly 
            100                 105                 110         


Phe Ala Arg Gly Leu Glu Pro Glu Arg Ile Ile Gly Ala Xaa Asp Ser 
        115                 120                 125             


Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asn Ser Asp Glu Ala 
    130                 135                 140                 


Asp Leu Val Pro Ala Lys Glu Ala Asn Val Lys Cys Pro Gln Val Val 
145                 150                 155                 160 


Ile Ser Phe Tyr Glu Glu Arg Leu Xaa Trp His Ser Tyr Pro Ser Glu 
                165                 170                 175     


Asp Asp Asp Lys Lys Asp Asp Lys Asn 
            180                 185 


<210> 5145
<211> 168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 5145
Met Gly Lys Lys Gln Asn Lys Lys Lys Val Glu Glu Val Leu Glu Glu 
1               5                   10                  15      


Glu Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val 
            20                  25                  30          


Lys Gly Lys Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Asp Glu 
        35                  40                  45              


Asp Asn Xaa Trp Glu Pro Glu Glu Asn Leu Asp Cys Pro Asp Leu Ile 
    50                  55                  60                  


Ala Glu Phe Leu Gln Ser Gln Lys Xaa Ala His Glu Xaa Asp Lys Ser 
65                  70                  75                  80  


Glu Gly Gly Lys Arg Lys Ala Asp Ser Asp Ser Glu Asp Lys Gly Glu 
                85                  90                  95      


Glu Ser Lys Pro Lys Lys Lys Lys Glu Glu Val Arg Ile Glu Ser Glu 
            100                 105                 110         


Lys Pro Arg Gly Phe Ala Arg Gly Leu Glu Pro Glu Arg Ile Ile Gly 
        115                 120                 125             


Ala Xaa Asp Ser Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asn 
    130                 135                 140                 


Ser Asp Glu Ala Asp Leu Val Pro Ala Lys Glu Ala Asn Val Lys Cys 
145                 150                 155                 160 


Pro Gln Val Val Ile Ser Phe Tyr 
                165             


<210> 5146
<211> 532
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<400> 5146
Met Glu Glu Leu Ser Ser Val Gly Glu Gln Val Phe Ala Ala Glu Cys 
1               5                   10                  15      


Ile Leu Ser Lys Arg Leu Arg Lys Gly Lys Leu Glu Tyr Leu Val Lys 
            20                  25                  30          


Trp Arg Gly Trp Ser Ser Lys His Asn Ser Trp Glu Pro Glu Glu Asn 
        35                  40                  45              


Ile Leu Asp Pro Arg Leu Leu Leu Ala Phe Gln Lys Lys Glu His Glu 
    50                  55                  60                  


Lys Glu Val Gln Asn Arg Lys Arg Gly Lys Arg Pro Arg Gly Arg Pro 
65                  70                  75                  80  


Arg Lys Leu Xaa Ala Met Ser Ser Cys Ser Arg Arg Ser Lys Leu Lys 
                85                  90                  95      


Glu Pro Asp Ala Pro Ser Lys Ser Lys Ser Ser Ser Ser Ser Ser Ser 
            100                 105                 110         


Ser Xaa Ser Ser Ser Ser Ser Ser Asp Glu Glu Asp Asp Ser Asp Leu 
        115                 120                 125             


Asp Ala Lys Arg Gly Pro Arg Gly Arg Glu Xaa His Pro Val Pro Gln 
    130                 135                 140                 


Lys Lys Ala Gln Ile Leu Val Ala Lys Pro Glu Leu Lys Asp Pro Ile 
145                 150                 155                 160 


Arg Lys Lys Arg Gly Arg Lys Pro Leu Pro Pro Glu Gln Lys Ala Xaa 
                165                 170                 175     


Arg Arg Pro Val Ser Leu Ala Lys Val Leu Lys Xaa Ala Arg Lys Asp 
            180                 185                 190         


Leu Gly Ala Pro Ala Ser Lys Leu Pro Pro Pro Leu Ser Ala Pro Val 
        195                 200                 205             


Ala Gly Leu Ala Ala Leu Lys Ala His Ala Lys Glu Ala Cys Gly Gly 
    210                 215                 220                 


Pro Ser Ala Met Ala Xaa Pro Glu Asn Leu Ala Ser Leu Met Lys Gly 
225                 230                 235                 240 


Met Ala Ser Ser Pro Gly Arg Gly Gly Ile Ser Trp Gln Ser Ser Ile 
                245                 250                 255     


Val His Tyr Met Asn Arg Met Xaa Gln Ser Gln Ala Gln Ala Ala Ser 
            260                 265                 270         


Arg Leu Ala Leu Lys Ala Gln Ala Xaa Asn Lys Cys Gly Leu Gly Leu 
        275                 280                 285             


Asp Leu Lys Val Arg Xaa Gln Lys Gly Glu Leu Gly Met Ser Pro Pro 
    290                 295                 300                 


Gly Ser Lys Ile Pro Lys Ala Pro Ser Gly Gly Ala Val Glu Gln Lys 
305                 310                 315                 320 


Val Gly Asn Xaa Gly Gly Pro Pro His Xaa His Gly Ala Ser Arg Val 
                325                 330                 335     


Pro Ala Gly Cys Pro Gly Pro Gln Pro Ala Pro Xaa Gln Glu Leu Ser 
            340                 345                 350         


Leu Gln Val Leu Asp Leu Gln Ser Val Lys Asn Gly Met Pro Gly Val 
        355                 360                 365             


Gly Leu Leu Ala Arg His Ala Xaa Ala Xaa Lys Gly Val Pro Ala Xaa 
    370                 375                 380                 


Asn Pro Ala Pro Gly Lys Gly Xaa Gly Ser Gly Leu Ile Gly Ala Ser 
385                 390                 395                 400 


Gly Ala Xaa Met Pro Xaa Asp Xaa Ser Lys Ser Glu Lys Leu Ala Ser 
                405                 410                 415     


Arg Ala Val Ala Pro Pro Xaa Pro Ala Ser Lys Arg Asp Cys Val Lys 
            420                 425                 430         


Gly Ser Ala Xaa Pro Ser Gly Gln Glu Ser Arg Xaa Ala Pro Gly Glu 
        435                 440                 445             


Ala Arg Lys Ala Ala Xaa Leu Pro Glu Met Ser Ala Gly Glu Glu Ser 
    450                 455                 460                 


Ser Ser Ser Asp Ser Asp Pro Asp Ser Ala Ser Pro Pro Ser Xaa Gly 
465                 470                 475                 480 


Gln Asn Pro Ser Val Ser Val Gln Xaa Ser Gln Asp Trp Lys Pro Xaa 
                485                 490                 495     


Arg Ser Leu Ile Glu His Val Phe Val Xaa Asp Val Xaa Ala Asn Leu 
            500                 505                 510         


Ile Xaa Val Xaa Val Lys Glu Ser Pro Xaa Ser Val Gly Phe Phe Asn 
        515                 520                 525             


Leu Arg His Tyr 
    530         


<210> 5147
<211> 211
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<400> 5147
Met Glu Glu Leu Ser Ser Val Gly Glu Gln Val Phe Ala Ala Glu Cys 
1               5                   10                  15      


Ile Leu Ser Lys Arg Leu Arg Lys Gly Lys Leu Glu Tyr Leu Val Lys 
            20                  25                  30          


Trp Arg Gly Trp Ser Ser Lys His Asn Ser Trp Glu Pro Glu Glu Asn 
        35                  40                  45              


Ile Leu Asp Pro Arg Leu Leu Leu Ala Phe Gln Lys Lys Glu His Glu 
    50                  55                  60                  


Lys Glu Val Gln Asn Arg Lys Arg Gly Lys Arg Pro Arg Gly Arg Pro 
65                  70                  75                  80  


Arg Lys Leu Xaa Ala Met Ser Ser Cys Ser Arg Arg Ser Lys Leu Lys 
                85                  90                  95      


Val Gly Gly Cys Ala Gly Tyr Ala Asp Pro Xaa Ser Gln His Pro Leu 
            100                 105                 110         


Gly Val Gly Gly Arg Gln Arg Glu Gly Leu Gly Pro Ser Gly Arg Gly 
        115                 120                 125             


Trp His Phe Cys Gln Gln Ser Val Pro Leu Leu Gly Lys Gln Glu Pro 
    130                 135                 140                 


Pro Phe Phe Leu Ser Leu Ser Phe Cys Cys Gln Gly Pro Gln Pro Ala 
145                 150                 155                 160 


Glu Ser Ser Ser Pro Pro Leu Pro Gly Ala Ser Cys Phe Ser Leu Ser 
                165                 170                 175     


Cys Xaa Pro Leu Cys Trp Val Ala Gly Ser Asn Cys Cys Arg Gln Ala 
            180                 185                 190         


Leu Phe Pro Pro Arg Gly Ser Leu Gly Asp Gly Lys Glu Gln Glu Ala 
        195                 200                 205             


Cys Val Gln 
    210     


<210> 5148
<211> 62
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<400> 5148
Met Ala Ser Asn Lys Xaa Xaa Leu Gln Lys Met Gly Lys Lys Gln Asn 
1               5                   10                  15      


Gly Lys Ser Lys Lys Val Glu Glu Ala Glu Pro Glu Glu Phe Val Val 
            20                  25                  30          


Glu Lys Val Leu Asp Arg Arg Val Val Asn Gly Lys Val Glu Tyr Phe 
        35                  40                  45              


Leu Lys Trp Lys Gly Phe Xaa Asp Ala Asp Asn Xaa Trp Glu 
    50                  55                  60          


<210> 5149
<211> 183
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 5149
Met Ala Ser Asn Lys Xaa Xaa Leu Gln Lys Met Gly Lys Lys Gln Asn 
1               5                   10                  15      


Gly Lys Ser Lys Lys Val Glu Glu Ala Glu Pro Glu Glu Phe Val Val 
            20                  25                  30          


Glu Lys Val Leu Asp Arg Arg Val Val Asn Gly Lys Val Glu Tyr Phe 
        35                  40                  45              


Leu Lys Trp Lys Gly Phe Xaa Asp Ala Asp Asn Xaa Trp Glu Pro Glu 
    50                  55                  60                  


Glu Asn Leu Asp Cys Pro Glu Leu Ile Glu Ala Phe Leu Asn Ser Gln 
65                  70                  75                  80  


Lys Ala Gly Lys Glu Lys Asp Gly Xaa Lys Arg Lys Ser Leu Ser Asp 
                85                  90                  95      


Ser Glu Ser Asp Asp Ser Lys Ser Lys Lys Lys Arg Asp Ala Ala Asp 
            100                 105                 110         


Lys Pro Arg Gly Phe Ala Arg Gly Leu Asp Pro Glu Arg Ile Ile Gly 
        115                 120                 125             


Ala Xaa Asp Ser Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asp 
    130                 135                 140                 


Ser Asp Glu Ala Asp Leu Val Leu Ala Lys Glu Ala Asn Met Lys Cys 
145                 150                 155                 160 


Pro Gln Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Xaa Trp His Ser 
                165                 170                 175     


Cys Pro Glu Asp Glu Ala Gln 
            180             


<210> 5150
<211> 101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 5150
Met Ala Ser Asn Lys Xaa Xaa Leu Gln Lys Met Gly Lys Lys Gln Asn 
1               5                   10                  15      


Gly Lys Ser Lys Lys Val Glu Glu Ala Glu Pro Glu Glu Phe Val Val 
            20                  25                  30          


Glu Lys Val Leu Asp Arg Arg Val Val Asn Gly Lys Val Glu Tyr Phe 
        35                  40                  45              


Leu Lys Trp Lys Gly Phe Xaa Glu Lys Leu Ala Lys Lys Lys Met Val 
    50                  55                  60                  


Gln Lys Glu Asn Leu Tyr Leu Xaa Val Asn Leu Met Xaa Ala Asn Gln 
65                  70                  75                  80  


Arg Arg Lys Glu Met Leu Leu Xaa Asn Gln Glu Asp Leu Pro Glu Val 
                85                  90                  95      


Leu Ile Leu Lys Glu 
            100     


<210> 5151
<211> 107
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 5151
Gln Lys Met Gly Lys Lys Gln Asn Gly Lys Ser Lys Lys Val Glu Glu 
1               5                   10                  15      


Ala Glu Pro Glu Glu Phe Val Val Glu Lys Val Leu Asp Arg Arg Val 
            20                  25                  30          


Val Asn Gly Lys Val Glu Tyr Phe Leu Lys Trp Lys Gly Phe Xaa Asp 
        35                  40                  45              


Ala Asp Asn Xaa Trp Glu Pro Glu Glu Asn Leu Asp Cys Pro Glu Leu 
    50                  55                  60                  


Ile Glu Ala Phe Leu Asn Ser Gln Lys Ala Gly Lys Glu Lys Asp Gly 
65                  70                  75                  80  


Xaa Lys Arg Lys Ser Leu Ser Asp Ser Glu Ser Asp Asp Ser Lys Ser 
                85                  90                  95      


Lys Lys Lys Arg Asp Ala Met Arg Lys Arg Asp 
            100                 105         


<210> 5152
<211> 560
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<400> 5152
Met Glu Leu Pro Ala Val Gly Glu His Val Phe Ala Val Glu Ser Ile 
1               5                   10                  15      


Glu Lys Lys Arg Ile Arg Lys Gly Arg Val Glu Tyr Leu Val Lys Trp 
            20                  25                  30          


Arg Gly Trp Ser Pro Lys Tyr Asn Xaa Trp Glu Pro Glu Glu Asn Ile 
        35                  40                  45              


Leu Asp Pro Arg Leu Leu Ile Ala Phe Gln Asn Arg Glu Arg Gln Glu 
    50                  55                  60                  


Gln Leu Met Gly Tyr Arg Lys Arg Gly Pro Lys Pro Lys Pro Leu Val 
65                  70                  75                  80  


Val Gln Val Pro Xaa Phe Ala Arg Arg Ser Asn Val Leu Xaa Gly Leu 
                85                  90                  95      


Gln Asp Ser Ser Xaa Asp Asn Arg Ala Lys Leu Asp Leu Gly Ala Gln 
            100                 105                 110         


Gly Lys Gly Gln Gly His Gln Tyr Glu Leu Asn Ser Lys Lys His His 
        115                 120                 125             


Gln Tyr Gln Pro His Ser Lys Glu Arg Ala Gly Lys Pro Pro Pro Pro 
    130                 135                 140                 


Gly Lys Ser Gly Lys Tyr Tyr Tyr Gln Leu Asn Ser Lys Lys His His 
145                 150                 155                 160 


Pro Tyr Gln Pro Asp Pro Lys Met Tyr Asp Leu Gln Tyr Gln Gly Gly 
                165                 170                 175     


His Lys Glu Ala Pro Ser Pro Xaa Cys Pro Asp Leu Gly Ala Lys Ser 
            180                 185                 190         


His Pro Pro Asp Lys Trp Ala Gln Gly Ala Gly Ala Lys Gly Tyr Leu 
        195                 200                 205             


Gly Ala Val Lys Pro Leu Ala Gly Ala Ala Gly Ala Pro Gly Lys Gly 
    210                 215                 220                 


Ser Glu Lys Gly Pro Pro Asn Gly Met Met Pro Ala Pro Lys Glu Ala 
225                 230                 235                 240 


Val Xaa Gly Asn Gly Ile Gly Gly Lys Met Lys Ile Val Lys Asn Lys 
                245                 250                 255     


Asn Lys Asn Gly Arg Ile Val Ile Val Met Ser Lys Tyr Met Glu Asn 
            260                 265                 270         


Gly Met Gln Ala Val Lys Ile Lys Ser Gly Glu Val Ala Glu Gly Glu 
        275                 280                 285             


Ala Arg Ser Pro Ser His Lys Lys Arg Ala Ala Asp Glu Arg His Pro 
    290                 295                 300                 


Pro Ala Asp Arg Xaa Phe Lys Lys Ala Ala Gly Ala Glu Glu Lys Lys 
305                 310                 315                 320 


Val Glu Ala Pro Pro Lys Arg Arg Glu Glu Glu Val Ser Gly Val Ser 
                325                 330                 335     


Asp Pro Gln Pro Gln Asp Ala Gly Ser Arg Lys Leu Ser Pro Xaa Lys 
            340                 345                 350         


Glu Ala Phe Gly Glu Gln Pro Leu Gln Leu Xaa Xaa Lys Pro Asp Leu 
        355                 360                 365             


Leu Ala Trp Asp Pro Ala Arg Asn Xaa His Pro Pro Ser His His Pro 
    370                 375                 380                 


His Pro His Pro His His His His His His His His His His His His 
385                 390                 395                 400 


Ala Val Gly Leu Asn Leu Ser His Val Arg Lys Arg Cys Leu Ser Glu 
                405                 410                 415     


Xaa His Gly Glu Arg Glu Pro Cys Lys Lys Arg Leu Xaa Ala Arg Ser 
            420                 425                 430         


Ile Ser Xaa Pro Xaa Cys Leu Gly Gly Ser Pro Ala Ala Glu Arg Pro 
        435                 440                 445             


Ala Asp Leu Pro Pro Ala Ala Ala Leu Pro Gln Pro Glu Val Ile Leu 
    450                 455                 460                 


Leu Asp Ser Asp Leu Asp Glu Pro Ile Asp Leu Arg Cys Val Lys Xaa 
465                 470                 475                 480 


Arg Ser Glu Ala Gly Glu Pro Pro Ser Ser Leu Gln Val Lys Pro Glu 
                485                 490                 495     


Xaa Pro Ala Ser Ala Ala Val Ala Val Ala Ala Ala Ala Ala Pro Xaa 
            500                 505                 510         


Xaa Xaa Ala Glu Lys Pro Pro Ala Glu Ala Gln Asp Glu Pro Ala Glu 
        515                 520                 525             


Ser Leu Ser Glu Phe Lys Pro Phe Phe Gly Asn Ile Ile Ile Xaa Asp 
    530                 535                 540                 


Val Xaa Ala Asn Cys Leu Xaa Val Xaa Phe Lys Glu Tyr Val Xaa Val 
545                 550                 555                 560 


<210> 5153
<211> 60
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<400> 5153
Met Glu Leu Pro Ala Val Gly Glu His Val Phe Ala Val Glu Ser Ile 
1               5                   10                  15      


Glu Lys Lys Arg Ile Arg Lys Gly Arg Val Glu Tyr Leu Val Lys Trp 
            20                  25                  30          


Arg Gly Trp Ser Pro Lys Tyr Asn Xaa Trp Glu Pro Glu Glu Asn Ile 
        35                  40                  45              


Leu Asp Pro Arg Leu Leu Ile Ala Phe Gln Asn Ser 
    50                  55                  60  


<210> 5154
<211> 90
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<400> 5154
Xaa Glu Asn Ile Leu Asp Pro Arg Leu Leu Ile Ala Phe Gln Asn Arg 
1               5                   10                  15      


Glu Arg Gln Glu Gln Leu Met Gly Tyr Arg Lys Arg Gly Pro Lys Pro 
            20                  25                  30          


Lys Pro Leu Val Val Gln Xaa Ser His Leu Leu Pro Pro Met Arg Gln 
        35                  40                  45              


Leu Arg Xaa Trp Trp Gly Leu Gly Arg Ser Arg Asn Ser Arg His Ala 
    50                  55                  60                  


Val Gly Leu Ser Pro Pro Ser Ser His Pro Cys Xaa Arg Ser Leu Arg 
65                  70                  75                  80  


Cys Leu Pro Leu Pro Val Val Pro Met Ser 
                85                  90  


<210> 5155
<211> 91
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 5155
Met Gly Lys Lys Xaa Lys Arg Xaa Ala Asp Ser Ser Ser Ser Glu Asp 
1               5                   10                  15      


Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val Lys 
            20                  25                  30          


Gly Gln Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Glu Glu His 
        35                  40                  45              


Asn Xaa Trp Glu Pro Glu Lys Asn Leu Asp Cys Pro Glu Leu Ile Ser 
    50                  55                  60                  


Glu Phe Met Lys Lys Tyr Lys Lys Met Lys Glu Gly Glu Asn Asn Lys 
65                  70                  75                  80  


Pro Arg Glu Lys Ser Glu Ser Asn Lys Arg Lys 
                85                  90      


<210> 5156
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<400> 5156
Met Gly Lys Lys Xaa Lys Arg Xaa Ala Asp Ser Ser Ser Ser Glu Asp 
1               5                   10                  15      


Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val Lys 
            20                  25                  30          


Gly Gln Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Glu Glu His 
        35                  40                  45              


Asn Xaa Trp Glu Pro Glu Lys Asn Leu Asp Cys Pro Glu Leu Ile Ser 
    50                  55                  60                  


Glu Phe Met Lys Lys Tyr Lys Lys Met Lys Glu Gly Glu Asn Asn Lys 
65                  70                  75                  80  


Pro Arg Glu Lys Ser Glu Ser Asn Lys Arg Lys Ser Asn Phe Ser Asn 
                85                  90                  95      


Ser Ala Asp Asp Ile Lys Ser Lys Lys Lys Arg Glu Gln Ser Asn Asp 
            100                 105                 110         


Ile Ala Arg Gly Phe Glu Arg Gly Leu Glu Pro Glu Lys Ile Ile Gly 
        115                 120                 125             


Ala Xaa Asp Ser Cys Gly Asp Leu Met Phe Leu Met Lys Trp Lys Asp 
    130                 135                 140                 


Xaa Asp Glu Ala Asp Leu Val Leu Ala Lys Glu Ala Asn Val Lys Cys 
145                 150                 155                 160 


Pro Gln Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Xaa Trp His Ala 
                165                 170                 175     


Tyr Pro Glu Asp Ala Glu Asn Lys Glu Lys Glu Xaa Ala Lys Ser 
            180                 185                 190     


<210> 5157
<211> 412
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<400> 5157
Met Glu Leu Ser Ala Val Gly Glu Arg Val Phe Ala Ala Glu Ser Ile 
1               5                   10                  15      


Ile Lys Arg Arg Ile Arg Lys Gly Arg Ile Glu Tyr Leu Val Lys Trp 
            20                  25                  30          


Lys Gly Trp Ala Ile Lys Tyr Ser Xaa Trp Glu Pro Glu Glu Asn Ile 
        35                  40                  45              


Leu Asp Ser Arg Leu Ile Ala Ala Phe Glu Gln Lys Glu Arg Glu Arg 
    50                  55                  60                  


Glu Leu Tyr Gly Pro Lys Lys Arg Gly Pro Lys Pro Lys Xaa Phe Leu 
65                  70                  75                  80  


Leu Lys Ala Arg Ala Gln Ala Glu Ala Leu Arg Ile Ser Asp Val His 
                85                  90                  95      


Phe Ser Val Lys Pro Ser Ala Ser Ala Ser Ser Pro Lys Leu His Ser 
            100                 105                 110         


Ser Ala Ala Val His Arg Leu Lys Lys Asp Ile Arg Arg Cys His Arg 
        115                 120                 125             


Met Ser Arg Arg Pro Leu Pro Arg Pro Asp Pro Gln Gly Gly Ser Pro 
    130                 135                 140                 


Gly Leu Arg Pro Pro Ile Ser Pro Phe Ser Glu Xaa Val Arg Ile Ile 
145                 150                 155                 160 


Asn Arg Lys Val Lys Pro Arg Glu Pro Lys Arg Asn Arg Ile Ile Leu 
                165                 170                 175     


Asn Leu Lys Val Ile Asp Lys Gly Ala Gly Gly Gly Gly Ala Gly Gln 
            180                 185                 190         


Gly Ala Gly Ala Leu Ala Arg Pro Lys Val Pro Ser Arg Asn Arg Val 
        195                 200                 205             


Ile Gly Lys Ser Lys Lys Phe Ser Glu Ser Val Leu Arg Xaa Gln Ile 
    210                 215                 220                 


Arg His Met Lys Phe Gly Ala Phe Ala Leu Tyr Lys Pro Pro Pro Ala 
225                 230                 235                 240 


Pro Leu Val Ala Pro Ser Pro Gly Lys Ala Glu Ala Ser Ala Pro Gly 
                245                 250                 255     


Pro Gly Leu Leu Leu Ala Ala Pro Ala Ala Pro Tyr Asp Ala Arg Ser 
            260                 265                 270         


Ser Gly Ser Ser Gly Cys Pro Ser Pro Xaa Pro Gln Ser Ser Asp Pro 
        275                 280                 285             


Asp Asp Xaa Pro Pro Lys Leu Leu Pro Glu Xaa Val Ser Pro Ser Ala 
    290                 295                 300                 


Pro Ser Trp Arg Glu Pro Glu Val Leu Asp Leu Ser Leu Pro Pro Glu 
305                 310                 315                 320 


Ser Ala Ala Xaa Ser Lys Arg Ala Pro Pro Glu Val Xaa Ala Ala Ala 
                325                 330                 335     


Gly Pro Ala Pro Pro Xaa Ala Pro Glu Pro Ala Gly Ala Ser Ser Glu 
            340                 345                 350         


Pro Glu Ala Gly Asp Trp Arg Pro Glu Met Ser Pro Cys Ser Asn Val 
        355                 360                 365             


Val Val Xaa Asp Val Xaa Ser Asn Leu Leu Xaa Val Xaa Ile Lys Glu 
    370                 375                 380                 


Phe Cys Asn Pro Glu Asp Phe Glu Lys Val Ala Ala Gly Val Ala Gly 
385                 390                 395                 400 


Ala Ala Gly Gly Gly Gly Ser Ile Gly Ala Ser Lys 
                405                 410         


<210> 5158
<211> 394
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<400> 5158
Met Glu Leu Ser Ala Val Gly Glu Arg Val Phe Ala Ala Glu Ser Ile 
1               5                   10                  15      


Ile Lys Arg Arg Ile Arg Lys Gly Arg Ile Glu Tyr Leu Val Lys Trp 
            20                  25                  30          


Lys Gly Trp Ala Ile Lys Tyr Ser Xaa Trp Glu Pro Glu Glu Asn Ile 
        35                  40                  45              


Leu Asp Ser Arg Leu Ile Ala Ala Phe Glu Gln Lys Glu Arg Glu Arg 
    50                  55                  60                  


Glu Leu Tyr Gly Pro Lys Lys Arg Gly Pro Lys Pro Lys Xaa Phe Leu 
65                  70                  75                  80  


Leu Lys Pro Ser Ala Ser Ala Ser Ser Pro Lys Leu His Ser Ser Ala 
                85                  90                  95      


Ala Val His Arg Leu Lys Lys Asp Ile Arg Arg Cys His Arg Met Ser 
            100                 105                 110         


Arg Arg Pro Leu Pro Arg Pro Asp Pro Gln Gly Gly Ser Pro Gly Leu 
        115                 120                 125             


Arg Pro Pro Ile Ser Pro Phe Ser Glu Xaa Val Arg Ile Ile Asn Arg 
    130                 135                 140                 


Lys Val Lys Pro Arg Glu Pro Lys Arg Asn Arg Ile Ile Leu Asn Leu 
145                 150                 155                 160 


Lys Val Ile Asp Lys Gly Ala Gly Gly Gly Gly Ala Gly Gln Gly Ala 
                165                 170                 175     


Gly Ala Leu Ala Arg Pro Lys Val Pro Ser Arg Asn Arg Val Ile Gly 
            180                 185                 190         


Lys Ser Lys Lys Phe Ser Glu Ser Val Leu Arg Xaa Gln Ile Arg His 
        195                 200                 205             


Met Lys Phe Gly Ala Phe Ala Leu Tyr Lys Pro Pro Pro Ala Pro Leu 
    210                 215                 220                 


Val Ala Pro Ser Pro Gly Lys Ala Glu Ala Ser Ala Pro Gly Pro Gly 
225                 230                 235                 240 


Leu Leu Leu Ala Ala Pro Ala Ala Pro Tyr Asp Ala Arg Ser Ser Gly 
                245                 250                 255     


Ser Ser Gly Cys Pro Ser Pro Xaa Pro Gln Ser Ser Asp Pro Asp Asp 
            260                 265                 270         


Xaa Pro Pro Lys Leu Leu Pro Glu Xaa Val Ser Pro Ser Ala Pro Ser 
        275                 280                 285             


Trp Arg Glu Pro Glu Val Leu Asp Leu Ser Leu Pro Pro Glu Ser Ala 
    290                 295                 300                 


Ala Xaa Ser Lys Arg Ala Pro Pro Glu Val Xaa Ala Ala Ala Gly Pro 
305                 310                 315                 320 


Ala Pro Pro Xaa Ala Pro Glu Pro Ala Gly Ala Ser Ser Glu Pro Glu 
                325                 330                 335     


Ala Gly Asp Trp Arg Pro Glu Met Ser Pro Cys Ser Asn Val Val Val 
            340                 345                 350         


Xaa Asp Val Xaa Ser Asn Leu Leu Xaa Val Xaa Ile Lys Glu Phe Cys 
        355                 360                 365             


Asn Pro Glu Asp Phe Glu Lys Val Ala Ala Gly Val Ala Gly Ala Ala 
    370                 375                 380                 


Gly Gly Gly Gly Ser Ile Gly Ala Ser Lys 
385                 390                 


<210> 5159
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<400> 5159
Met Glu Leu Ser Ala Ile Gly Glu Gln Val Phe Ala Val Glu Ser Ile 
1               5                   10                  15      


Arg Lys Lys Arg Val Arg Lys Gly Lys Val Glu Tyr Leu Val Lys Trp 
            20                  25                  30          


Lys Gly Trp Pro Pro Lys Glu Glu Arg Asp Arg Ala Ser Gly Tyr Arg 
        35                  40                  45              


Lys Arg Gly Pro Lys Pro Lys Arg Leu Leu Leu Gln Arg Leu Tyr Ser 
    50                  55                  60                  


Met Asp Leu Arg Ser Ser His Lys Ala Lys Gly Lys Glu Lys Leu Cys 
65                  70                  75                  80  


Phe Ser Leu Xaa Cys Pro Leu Gly Ser Gly Ser Pro Glu Gly Val Val 
                85                  90                  95      


Lys Ala Gly Ala Pro Glu Leu Val Asp Lys Gly Pro Leu Val Pro Xaa 
            100                 105                 110         


Leu Pro Phe Pro Leu Arg Lys Pro Arg 
        115                 120     


<210> 5160
<211> 158
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<400> 5160
Met Glu Leu Ser Ala Ile Gly Glu Gln Val Phe Ala Val Glu Ser Ile 
1               5                   10                  15      


Arg Lys Lys Arg Val Arg Lys Gly Lys Val Glu Tyr Leu Val Lys Trp 
            20                  25                  30          


Lys Gly Trp Pro Pro Lys Tyr Ser Xaa Trp Glu Pro Glu Glu His Ile 
        35                  40                  45              


Leu Asp Pro Arg Leu Val Met Ala Tyr Glu Glu Lys Glu Glu Arg Asp 
    50                  55                  60                  


Arg Ala Ser Gly Tyr Arg Lys Arg Gly Pro Lys Pro Lys Arg Leu Leu 
65                  70                  75                  80  


Leu Gln Glu Pro Pro Ala Pro Asp Val Leu Gln Ala Ala Gly Glu Trp 
                85                  90                  95      


Glu Pro Ala Ala Gln Pro Pro Glu Glu Glu Ala Asp Ala Asp Leu Ala 
            100                 105                 110         


Glu Gly Pro Pro Pro Trp Xaa Pro Ala Leu Pro Ser Ser Glu Val Xaa 
        115                 120                 125             


Val Xaa Asp Ile Xaa Ala Asn Ser Ile Xaa Val Xaa Phe Arg Glu Ala 
    130                 135                 140                 


Gln Ala Ala Glu Gly Phe Phe Arg Asp Arg Ser Gly Lys Phe 
145                 150                 155             


<210> 5161
<211> 251
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<400> 5161
Met Glu Leu Ser Ala Ile Gly Glu Gln Val Phe Ala Val Glu Ser Ile 
1               5                   10                  15      


Arg Lys Lys Arg Val Arg Lys Gly Lys Val Glu Tyr Leu Val Lys Trp 
            20                  25                  30          


Lys Gly Trp Pro Pro Lys Tyr Ser Xaa Trp Glu Pro Glu Glu His Ile 
        35                  40                  45              


Leu Asp Pro Arg Leu Val Met Ala Tyr Glu Glu Lys Glu Glu Arg Asp 
    50                  55                  60                  


Arg Ala Ser Gly Tyr Arg Lys Arg Gly Pro Lys Pro Lys Arg Leu Leu 
65                  70                  75                  80  


Leu Gln Arg Leu Tyr Ser Met Asp Leu Arg Ser Ser His Lys Ala Lys 
                85                  90                  95      


Gly Lys Glu Lys Leu Cys Phe Ser Leu Xaa Cys Pro Leu Gly Ser Gly 
            100                 105                 110         


Ser Pro Glu Gly Val Val Lys Ala Gly Ala Pro Glu Leu Val Asp Lys 
        115                 120                 125             


Gly Pro Leu Val Pro Xaa Leu Pro Phe Pro Leu Arg Lys Pro Arg Lys 
    130                 135                 140                 


Ala His Lys Tyr Leu Arg Leu Ser Arg Lys Lys Phe Pro Pro Arg Gly 
145                 150                 155                 160 


Pro Asn Leu Glu Ser His Ser His Arg Arg Glu Leu Phe Leu Gln Glu 
                165                 170                 175     


Pro Pro Ala Pro Asp Val Leu Gln Ala Ala Gly Glu Trp Glu Pro Ala 
            180                 185                 190         


Ala Gln Pro Pro Glu Glu Glu Ala Asp Ala Asp Leu Ala Glu Gly Pro 
        195                 200                 205             


Pro Pro Trp Xaa Pro Ala Leu Pro Ser Ser Glu Val Xaa Val Xaa Asp 
    210                 215                 220                 


Ile Xaa Ala Asn Ser Ile Xaa Val Xaa Phe Arg Glu Ala Gln Ala Ala 
225                 230                 235                 240 


Glu Gly Phe Phe Arg Asp Arg Ser Gly Lys Phe 
                245                 250     


<210> 5162
<211> 389
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<400> 5162
Met Glu Leu Ser Ala Val Gly Glu Arg Val Phe Ala Ala Glu Ala Leu 
1               5                   10                  15      


Leu Lys Arg Arg Ile Arg Lys Gly Arg Met Glu Tyr Leu Val Lys Trp 
            20                  25                  30          


Lys Gly Trp Ser Gln Lys Tyr Ser Xaa Trp Glu Pro Glu Glu Asn Ile 
        35                  40                  45              


Leu Asp Ala Arg Leu Leu Ala Ala Phe Glu Glu Arg Glu Arg Glu Met 
    50                  55                  60                  


Glu Leu Tyr Gly Pro Lys Lys Arg Gly Pro Lys Pro Lys Xaa Phe Leu 
65                  70                  75                  80  


Leu Lys Ala Gln Ala Lys Ala Lys Ala Lys Xaa Tyr Glu Phe Arg Ser 
                85                  90                  95      


Asp Ser Ala Arg Gly Ile Arg Ile Pro Tyr Pro Gly Arg Ser Pro Gln 
            100                 105                 110         


Asp Leu Ala Ser Xaa Ser Arg Ala Arg Glu Gly Leu Arg Asn Met Gly 
        115                 120                 125             


Leu Ser Pro Pro Ala Ser Ser Xaa Ser Xaa Ser Ser Xaa Cys Arg Ala 
    130                 135                 140                 


Glu Ala Pro Arg Asp Arg Asp Arg Asp Arg Asp Arg Asp Arg Glu Arg 
145                 150                 155                 160 


Asp Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg 
                165                 170                 175     


Glu Arg Glu Arg Gly Xaa Ser Arg Val Asp Asp Lys Pro Ser Ser Pro 
            180                 185                 190         


Gly Asp Ser Ser Lys Lys Arg Gly Pro Lys Pro Arg Lys Glu Leu Pro 
        195                 200                 205             


Asp Pro Ser Gln Arg Pro Leu Gly Glu Pro Ser Ala Gly Leu Gly Glu 
    210                 215                 220                 


Tyr Leu Lys Gly Arg Lys Leu Asp Asp Xaa Pro Ser Gly Ala Gly Lys 
225                 230                 235                 240 


Phe Pro Ala Gly His Ser Val Ile Gln Leu Ala Arg Arg Gln Asp Ser 
                245                 250                 255     


Asp Leu Val Gln Cys Gly Val Xaa Ser Pro Ser Ser Ala Glu Ala Xaa 
            260                 265                 270         


Gly Lys Leu Ala Val Asp Xaa Phe Pro Ala Arg Val Ile Lys His Arg 
        275                 280                 285             


Ala Ala Phe Leu Glu Ala Lys Gly Gln Gly Ala Leu Asp Pro Asn Gly 
    290                 295                 300                 


Xaa Arg Val Arg His Gly Ser Gly Pro Pro Ser Ser Gly Gly Gly Leu 
305                 310                 315                 320 


Tyr Arg Asp Met Gly Ala Gln Gly Gly Arg Pro Ser Leu Ile Ala Arg 
                325                 330                 335     


Ile Pro Val Ala Arg Ile Leu Gly Asp Pro Glu Glu Glu Ser Trp Ser 
            340                 345                 350         


Pro Ser Leu Xaa Asn Leu Glu Lys Val Val Val Xaa Asp Val Xaa Ser 
        355                 360                 365             


Asn Phe Leu Xaa Val Xaa Ile Lys Glu Ser Asn Xaa Asp Gln Gly Phe 
    370                 375                 380                 


Phe Lys Glu Lys Arg 
385                 


<210> 5163
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<400> 5163
Met Glu Tyr Leu Val Lys Trp Lys Gly Trp Ser Gln Lys Tyr Ser Xaa 
1               5                   10                  15      


Trp Glu Pro Glu Glu Asn Ile Leu Asp Ala Arg Leu Leu Ala Ala Phe 
            20                  25                  30          


Glu Glu Arg Glu Arg Glu Met Glu Leu Tyr Gly Pro Lys Lys Arg Gly 
        35                  40                  45              


Pro Lys Pro Lys Xaa Phe Leu Leu Lys Ala Gln Ala Lys Ala Lys Ala 
    50                  55                  60                  


Lys Xaa Tyr Glu Phe Arg Ser Asp Ser Ala Arg Gly Ile Arg Ile Pro 
65                  70                  75                  80  


Tyr Pro Gly Arg Ser Pro Gln Asp Leu Ala Ser Xaa Ser Arg Ala Arg 
                85                  90                  95      


Glu Gly Leu Arg Asn Met Gly Leu Ser Pro Pro Ala Ser Ser Xaa Ser 
            100                 105                 110         


Xaa Ser Ser Xaa Cys Arg Ala Glu Ala Pro Arg Asp Arg Asp Arg Asp 
        115                 120                 125             


Arg Asp Arg Asp Arg Glu Arg Asp Arg Glu Arg Glu Arg Glu Arg Glu 
    130                 135                 140                 


Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Gly Xaa Ser Arg Val 
145                 150                 155                 160 


Asp Asp Lys Pro Ser Ser Pro Gly Asp Ser Ser Lys Lys Arg Gly 
                165                 170                 175 


<210> 5164
<211> 242
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<400> 5164
Met Ser Ala Ala His Val Gly Lys Ser Gly Gly Gln Glu Gly Arg Met 
1               5                   10                  15      


Glu Tyr Leu Val Lys Trp Lys Gly Trp Ser Gln Lys Tyr Ser Xaa Trp 
            20                  25                  30          


Glu Pro Glu Glu Asn Ile Leu Asp Ala Arg Leu Leu Ala Ala Phe Glu 
        35                  40                  45              


Glu Arg Glu Arg Glu Met Glu Leu Tyr Gly Pro Lys Lys Arg Gly Pro 
    50                  55                  60                  


Lys Pro Lys Xaa Phe Leu Leu Lys Ala Gln Ala Lys Ala Lys Ala Lys 
65                  70                  75                  80  


Xaa Tyr Glu Phe Arg Ser Asp Ser Ala Arg Gly Ile Arg Ile Pro Tyr 
                85                  90                  95      


Pro Gly Arg Ser Pro Gln Asp Leu Ala Ser Xaa Ser Arg Ala Arg Glu 
            100                 105                 110         


Gly Leu Arg Asn Met Gly Leu Ser Pro Pro Ala Ser Ser Xaa Ser Xaa 
        115                 120                 125             


Ser Ser Xaa Cys Arg Ala Glu Ala Pro Arg Asp Arg Asp Arg Asp Arg 
    130                 135                 140                 


Asp Arg Asp Arg Glu Arg Asp Arg Glu Arg Glu Arg Glu Arg Glu Arg 
145                 150                 155                 160 


Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Gly Xaa Ser Arg Val Asp 
                165                 170                 175     


Asp Lys Pro Ser Ser Pro Gly Asp Ser Ser Lys Lys Arg Gly Pro Lys 
            180                 185                 190         


Pro Arg Lys Glu Leu Pro Asp Pro Ser Gln Arg Pro Leu Gly Glu Pro 
        195                 200                 205             


Ser Ala Gly Leu Gly Glu Tyr Leu Lys Gly Arg Lys Leu Asp Asp Xaa 
    210                 215                 220                 


Pro Ser Gly Ala Gly Lys Phe Pro Ala Gly His Ser Val Ile Gln Leu 
225                 230                 235                 240 


Ala Arg 
        


<210> 5165
<211> 169
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<400> 5165
Met Asp Lys Cys Gln Lys His Asp Val Glu Cys Glu Lys Pro Asp Ala 
1               5                   10                  15      


Asn Glu Asp Ser Leu Cys Asn Ser Val His Val Gln Trp Pro Gly Glu 
            20                  25                  30          


Gly Ser Xaa Gly Phe Ala Phe Ile Arg Pro Lys Met Pro Phe Phe Gly 
        35                  40                  45              


Asn Xaa Phe Ser Pro Lys Lys Xaa Pro Pro Arg Lys Ser Ala Ser Leu 
    50                  55                  60                  


Ser Asn Leu His Ser Leu Asp Arg Ser Xaa Arg Glu Val Glu Leu Gly 
65                  70                  75                  80  


Leu Glu Tyr Gly Ser Pro Xaa Met Asn Leu Ala Gly Gln Ser Leu Lys 
                85                  90                  95      


Phe Glu Asn Gly Gln Trp Ile Ala Glu Xaa Gly Val Ser Gly Gly Val 
            100                 105                 110         


Asp Arg Arg Glu Val Gln Arg Leu Arg Arg Arg Asn Gln Gln Leu Glu 
        115                 120                 125             


Glu Glu Asn Asn Leu Leu Arg Leu Lys Val Asp Ile Leu Leu Asp Met 
    130                 135                 140                 


Leu Ser Glu Ser Xaa Ala Glu Ser His Leu Met Glu Lys Glu Leu Asp 
145                 150                 155                 160 


Glu Leu Arg Ile Ser Arg Lys Arg Lys 
                165                 


<210> 5166
<211> 61
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<400> 5166
Met Pro Phe Phe Gly Asn Xaa Phe Ser Pro Lys Lys Xaa Pro Pro Arg 
1               5                   10                  15      


Lys Ser Ala Ser Leu Ser Asn Leu His Ser Leu Asp Arg Ser Xaa Arg 
            20                  25                  30          


Glu Val Glu Leu Gly Leu Glu Tyr Gly Ser Pro Xaa Met Asn Leu Ala 
        35                  40                  45              


Gly Gln Ser Leu Lys Phe Glu Asn Gly Gln Trp Ile Ala 
    50                  55                  60      


<210> 5167
<211> 101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<400> 5167
Met Pro Phe Phe Gly Asn Xaa Phe Ser Pro Lys Lys Xaa Pro Pro Arg 
1               5                   10                  15      


Lys Ser Ala Ser Leu Ser Asn Leu His Ser Leu Asp Arg Ser Xaa Arg 
            20                  25                  30          


Glu Val Glu Leu Gly Leu Glu Tyr Gly Ser Pro Xaa Met Asn Leu Ala 
        35                  40                  45              


Gly Gln Ser Leu Lys Phe Glu Asn Gly Gln Trp Ile Ala Glu Xaa Gly 
    50                  55                  60                  


Val Ser Gly Gly Val Asp Arg Arg Glu Val Gln Arg Leu Arg Arg Arg 
65                  70                  75                  80  


Asn Gln Gln Leu Glu Glu Glu Asn Asn Leu Leu Arg Leu Lys Val Asp 
                85                  90                  95      


Ile Leu Leu Asp Met 
            100     


<210> 5168
<211> 126
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<400> 5168
Met Pro Phe Phe Gly Asn Xaa Phe Ser Pro Lys Lys Xaa Pro Pro Arg 
1               5                   10                  15      


Lys Ser Ala Ser Leu Ser Asn Leu His Ser Leu Asp Arg Ser Xaa Arg 
            20                  25                  30          


Glu Val Glu Leu Gly Leu Glu Tyr Gly Ser Pro Xaa Met Asn Leu Ala 
        35                  40                  45              


Gly Gln Ser Leu Lys Phe Glu Asn Gly Gln Trp Ile Ala Glu Xaa Gly 
    50                  55                  60                  


Val Ser Gly Gly Val Asp Arg Arg Glu Val Gln Arg Leu Arg Arg Arg 
65                  70                  75                  80  


Asn Gln Gln Leu Glu Glu Glu Asn Asn Leu Leu Arg Leu Lys Val Asp 
                85                  90                  95      


Ile Leu Leu Asp Met Leu Ser Glu Ser Xaa Ala Glu Ser His Leu Met 
            100                 105                 110         


Glu Lys Glu Leu Asp Glu Leu Arg Ile Ser Arg Lys Arg Lys 
        115                 120                 125     


<210> 5169
<211> 950
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<400> 5169
Met His Lys Arg Lys Gly Pro Pro Gly Pro Pro Gly Arg Gly Ala Ala 
1               5                   10                  15      


Ala Ala Arg Gln Leu Gly Leu Leu Val Asp Leu Ser Pro Asp Gly Leu 
            20                  25                  30          


Met Ile Pro Glu Asp Gly Ala Asn Asp Glu Glu Leu Glu Ala Glu Phe 
        35                  40                  45              


Leu Ala Leu Val Gly Gly Gln Pro Pro Ala Leu Glu Lys Leu Lys Gly 
    50                  55                  60                  


Lys Gly Pro Leu Pro Met Glu Ala Ile Glu Lys Met Ala Ser Leu Cys 
65                  70                  75                  80  


Met Arg Asp Pro Asp Glu Asp Glu Glu Glu Gly Xaa Asp Glu Asp Asp 
                85                  90                  95      


Leu Glu Ala Asp Asp Asp Leu Leu Ala Glu Leu Asn Glu Val Leu Gly 
            100                 105                 110         


Glu Glu Gln Lys Ala Ser Glu Xaa Pro Pro Pro Val Ala Gln Pro Lys 
        115                 120                 125             


Pro Glu Ala Pro His Pro Gly Leu Glu Xaa Xaa Leu Gln Glu Arg Leu 
    130                 135                 140                 


Ala Leu Tyr Gln Xaa Ala Ile Glu Ser Ala Arg Gln Ala Gly Asp Ser 
145                 150                 155                 160 


Ala Lys Met Arg Arg Tyr Asp Arg Gly Leu Lys Xaa Leu Glu Asn Leu 
                165                 170                 175     


Leu Ala Ser Ile Arg Lys Gly Asn Ala Ile Asp Glu Ala Asp Ile Pro 
            180                 185                 190         


Pro Pro Val Ala Ile Gly Lys Gly Pro Ala Ser Xaa Pro Xaa Tyr Ser 
        195                 200                 205             


Pro Ala Pro Xaa Gln Pro Ala Pro Arg Ile Ala Ser Ala Pro Glu Pro 
    210                 215                 220                 


Arg Val Xaa Leu Glu Gly Pro Ser Ala Xaa Ala Pro Ala Ser Ser Pro 
225                 230                 235                 240 


Gly Leu Ala Lys Pro Gln Met Pro Pro Gly Pro Cys Ser Pro Gly Pro 
                245                 250                 255     


Leu Ala Gln Leu Gln Ser Arg Gln Arg Asp Tyr Lys Leu Ala Ala Leu 
            260                 265                 270         


His Ala Lys Gln Gln Gly Asp Xaa Xaa Ala Ala Ala Arg His Phe Arg 
        275                 280                 285             


Val Ala Lys Ser Phe Asp Ala Val Leu Glu Ala Leu Ser Arg Gly Glu 
    290                 295                 300                 


Pro Val Asp Leu Ser Cys Leu Pro Pro Pro Pro Asp Gln Leu Pro Pro 
305                 310                 315                 320 


Asp Pro Pro Ser Pro Pro Ser Gln Pro Pro Xaa Pro Ala Xaa Ala Pro 
                325                 330                 335     


Ser Xaa Xaa Glu Val Pro Pro Pro Pro Arg Xaa Leu Leu Glu Ala Leu 
            340                 345                 350         


Glu Gln Arg Met Glu Arg Tyr Gln Val Ala Ala Ala Gln Ala Lys Ser 
        355                 360                 365             


Lys Gly Asp Gln Arg Lys Ala Arg Met His Glu Arg Ile Val Lys Gln 
    370                 375                 380                 


Tyr Gln Asp Ala Ile Arg Ala His Lys Ala Gly Arg Ala Val Asp Val 
385                 390                 395                 400 


Ala Glu Leu Pro Val Pro Pro Gly Phe Pro Pro Ile Gln Gly Leu Glu 
                405                 410                 415     


Ala Xaa Lys Pro Xaa Gln Gln Ser Leu Val Gly Val Leu Glu Xaa Ala 
            420                 425                 430         


Met Lys Leu Ala Asn Gln Asp Glu Gly Pro Glu Asp Glu Glu Asp Glu 
        435                 440                 445             


Val Pro Lys Lys Gln Asn Ser Pro Val Ala Pro Xaa Ala Gln Pro Lys 
    450                 455                 460                 


Ala Pro Pro Ser Arg Xaa Pro Gln Ser Gly Ser Ala Pro Xaa Ala Lys 
465                 470                 475                 480 


Ala Pro Pro Lys Ala Xaa Ser Xaa Arg Ala Gln Gln Gln Leu Ala Phe 
                485                 490                 495     


Leu Glu Gly Arg Lys Lys Gln Leu Leu Gln Ala Ala Leu Arg Ala Lys 
            500                 505                 510         


Gln Lys Asn Asp Val Glu Gly Ala Lys Met His Leu Arg Gln Ala Lys 
        515                 520                 525             


Gly Leu Glu Pro Met Leu Glu Ala Ser Arg Asn Gly Leu Pro Val Asp 
    530                 535                 540                 


Ile Xaa Lys Val Pro Pro Ala Pro Val Asn Lys Asp Asp Phe Ala Leu 
545                 550                 555                 560 


Val Gln Arg Pro Gly Pro Gly Leu Ser Gln Glu Ala Ala Arg Arg Tyr 
                565                 570                 575     


Gly Glu Leu Xaa Lys Leu Ile Arg Gln Gln His Glu Met Cys Leu Asn 
            580                 585                 590         


His Ser Asn Gln Phe Xaa Gln Leu Gly Asn Ile Xaa Glu Xaa Xaa Lys 
        595                 600                 605             


Phe Glu Lys Leu Ala Glu Asp Cys Lys Arg Ser Met Asp Ile Leu Lys 
    610                 615                 620                 


Gln Ala Phe Val Arg Gly Leu Pro Xaa Pro Xaa Ala Arg Phe Glu Gln 
625                 630                 635                 640 


Arg Xaa Phe Ser Val Ile Lys Ile Phe Pro Asp Leu Ser Ser Asn Asp 
                645                 650                 655     


Met Leu Leu Phe Ile Val Lys Gly Ile Asn Leu Pro Xaa Pro Pro Gly 
            660                 665                 670         


Leu Ser Pro Gly Asp Leu Asp Val Phe Val Arg Phe Asp Phe Pro Tyr 
        675                 680                 685             


Pro Asn Val Glu Glu Ala Gln Lys Asp Lys Xaa Ser Val Ile Lys Asn 
    690                 695                 700                 


Xaa Asp Ser Pro Glu Phe Lys Glu Gln Phe Lys Leu Cys Ile Asn Arg 
705                 710                 715                 720 


Ser His Arg Gly Phe Arg Arg Ala Ile Gln Xaa Lys Gly Ile Lys Phe 
                725                 730                 735     


Glu Val Val His Lys Gly Gly Leu Phe Lys Xaa Asp Arg Val Leu Gly 
            740                 745                 750         


Xaa Ala Gln Leu Lys Leu Asp Ala Leu Glu Ile Ala Cys Glu Val Arg 
        755                 760                 765             


Glu Ile Leu Glu Val Leu Asp Gly Arg Arg Pro Xaa Gly Gly Arg Leu 
    770                 775                 780                 


Glu Val Met Val Arg Ile Arg Glu Pro Leu Xaa Ala Gln Gln Leu Glu 
785                 790                 795                 800 


Xaa Xaa Xaa Glu Arg Trp Leu Val Ile Asp Pro Val Pro Ala Ala Val 
                805                 810                 815     


Pro Xaa Val Ala Gly Pro Lys Gly Lys Ala Pro Pro Val Pro Ala Pro 
            820                 825                 830         


Ala Arg Glu Ser Gly Asn Arg Ser Ala Arg Pro Leu His Ser Leu Ser 
        835                 840                 845             


Val Leu Ala Phe Asp Gln Glu Arg Leu Glu Arg Lys Ile Leu Ala Leu 
    850                 855                 860                 


Arg Gln Ala Arg Arg Pro Val Pro Pro Glu Val Ala Gln Gln Tyr Gln 
865                 870                 875                 880 


Asp Ile Met Gln Arg Ser Gln Trp Gln Arg Ala Gln Leu Glu Gln Gly 
                885                 890                 895     


Gly Val Gly Ile Arg Arg Glu Tyr Ala Ala Gln Leu Glu Arg Gln Leu 
            900                 905                 910         


Gln Phe Tyr Xaa Glu Ala Ala Arg Arg Leu Gly Asn Asp Gly Ser Arg 
        915                 920                 925             


Asp Ala Ala Lys Glu Ala Leu Tyr Arg Arg Asn Leu Val Glu Ser Glu 
    930                 935                 940                 


Leu Gln Arg Leu Arg Arg 
945                 950 


<210> 5170
<211> 951
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<400> 5170
Met His Lys Arg Lys Gly Pro Pro Gly Pro Pro Gly Arg Gly Ala Ala 
1               5                   10                  15      


Ala Ala Arg Gln Leu Gly Leu Leu Val Asp Leu Ser Pro Asp Gly Leu 
            20                  25                  30          


Met Ile Pro Glu Asp Gly Ala Asn Asp Glu Glu Leu Glu Ala Glu Phe 
        35                  40                  45              


Leu Ala Leu Val Gly Gly Gln Pro Pro Ala Leu Glu Lys Leu Lys Gly 
    50                  55                  60                  


Lys Gly Pro Leu Pro Met Glu Ala Ile Glu Lys Met Ala Ser Leu Cys 
65                  70                  75                  80  


Met Arg Asp Pro Asp Glu Asp Glu Glu Glu Gly Xaa Asp Glu Asp Asp 
                85                  90                  95      


Leu Glu Ala Asp Asp Asp Leu Leu Ala Glu Leu Asn Glu Val Leu Gly 
            100                 105                 110         


Glu Glu Gln Lys Ala Ser Glu Xaa Pro Pro Pro Val Ala Gln Pro Lys 
        115                 120                 125             


Pro Glu Ala Pro His Pro Gly Leu Glu Xaa Xaa Leu Gln Glu Arg Leu 
    130                 135                 140                 


Ala Leu Tyr Gln Xaa Ala Ile Glu Ser Ala Arg Gln Ala Gly Asp Ser 
145                 150                 155                 160 


Ala Lys Met Arg Arg Tyr Asp Arg Gly Leu Lys Xaa Leu Glu Asn Leu 
                165                 170                 175     


Leu Ala Ser Ile Arg Lys Gly Asn Ala Ile Asp Glu Ala Asp Ile Pro 
            180                 185                 190         


Pro Pro Val Ala Ile Gly Lys Gly Pro Ala Ser Xaa Pro Xaa Tyr Ser 
        195                 200                 205             


Pro Ala Pro Xaa Gln Pro Ala Pro Arg Ile Ala Ser Ala Pro Glu Pro 
    210                 215                 220                 


Arg Val Xaa Leu Glu Gly Pro Ser Ala Xaa Ala Pro Ala Ser Ser Pro 
225                 230                 235                 240 


Gly Leu Ala Lys Pro Gln Met Pro Pro Gly Pro Cys Ser Pro Gly Pro 
                245                 250                 255     


Leu Ala Gln Leu Gln Ser Arg Gln Arg Asp Tyr Lys Leu Ala Ala Leu 
            260                 265                 270         


His Ala Lys Gln Gln Gly Asp Xaa Xaa Ala Ala Ala Arg His Phe Arg 
        275                 280                 285             


Val Ala Lys Ser Phe Asp Ala Val Leu Glu Ala Leu Ser Arg Gly Glu 
    290                 295                 300                 


Pro Val Asp Leu Ser Cys Leu Pro Pro Pro Pro Asp Gln Leu Pro Pro 
305                 310                 315                 320 


Asp Pro Pro Ser Pro Pro Ser Gln Pro Pro Xaa Pro Ala Xaa Ala Pro 
                325                 330                 335     


Ser Xaa Xaa Glu Val Pro Pro Pro Pro Arg Xaa Leu Leu Glu Ala Leu 
            340                 345                 350         


Glu Gln Arg Met Glu Arg Tyr Gln Val Ala Ala Ala Gln Ala Lys Ser 
        355                 360                 365             


Lys Gly Asp Gln Arg Lys Ala Arg Met His Glu Arg Ile Val Lys Gln 
    370                 375                 380                 


Tyr Gln Asp Ala Ile Arg Ala His Lys Ala Gly Arg Ala Val Asp Val 
385                 390                 395                 400 


Ala Glu Leu Pro Val Pro Pro Gly Phe Pro Pro Ile Gln Gly Leu Glu 
                405                 410                 415     


Ala Xaa Lys Pro Xaa Gln Gln Ser Leu Val Gly Val Leu Glu Xaa Ala 
            420                 425                 430         


Met Lys Leu Ala Asn Gln Asp Glu Gly Pro Glu Asp Glu Glu Asp Glu 
        435                 440                 445             


Val Pro Lys Lys Gln Asn Ser Pro Val Ala Pro Xaa Ala Gln Pro Lys 
    450                 455                 460                 


Ala Pro Pro Ser Arg Xaa Pro Gln Ser Gly Ser Ala Pro Xaa Ala Lys 
465                 470                 475                 480 


Ala Pro Pro Lys Ala Xaa Ser Xaa Arg Ala Gln Gln Gln Leu Ala Phe 
                485                 490                 495     


Leu Glu Gly Arg Lys Lys Gln Leu Leu Gln Ala Ala Leu Arg Ala Lys 
            500                 505                 510         


Gln Lys Asn Asp Val Glu Gly Ala Lys Met His Leu Arg Gln Ala Lys 
        515                 520                 525             


Gly Leu Glu Pro Met Leu Glu Ala Ser Arg Asn Gly Leu Pro Val Asp 
    530                 535                 540                 


Ile Xaa Lys Val Pro Pro Ala Pro Val Asn Lys Asp Asp Phe Ala Leu 
545                 550                 555                 560 


Val Gln Arg Pro Gly Pro Gly Leu Ser Gln Glu Ala Ala Arg Arg Tyr 
                565                 570                 575     


Gly Glu Leu Xaa Lys Leu Ile Arg Gln Gln His Glu Met Cys Leu Asn 
            580                 585                 590         


His Ser Asn Gln Phe Xaa Gln Leu Gly Asn Ile Xaa Glu Xaa Xaa Lys 
        595                 600                 605             


Phe Glu Lys Leu Ala Glu Asp Cys Lys Arg Ser Met Asp Ile Leu Lys 
    610                 615                 620                 


Gln Ala Phe Val Arg Gly Leu Pro Xaa Pro Xaa Ala Arg Phe Glu Gln 
625                 630                 635                 640 


Arg Xaa Phe Ser Val Ile Lys Ile Phe Pro Asp Leu Ser Ser Asn Asp 
                645                 650                 655     


Met Leu Leu Phe Ile Val Lys Gly Ile Asn Leu Pro Xaa Pro Pro Gly 
            660                 665                 670         


Leu Ser Pro Gly Asp Leu Asp Val Phe Val Arg Phe Asp Phe Pro Tyr 
        675                 680                 685             


Pro Asn Val Glu Glu Ala Gln Lys Asp Lys Xaa Ser Val Ile Lys Asn 
    690                 695                 700                 


Xaa Asp Ser Pro Glu Phe Lys Glu Gln Phe Lys Leu Cys Ile Asn Arg 
705                 710                 715                 720 


Ser His Arg Gly Phe Arg Arg Ala Ile Gln Xaa Lys Gly Ile Lys Phe 
                725                 730                 735     


Glu Val Val His Lys Gly Gly Leu Phe Lys Xaa Asp Arg Val Leu Gly 
            740                 745                 750         


Xaa Ala Gln Leu Lys Leu Asp Ala Leu Glu Ile Ala Cys Glu Val Arg 
        755                 760                 765             


Glu Ile Leu Glu Val Leu Asp Gly Arg Arg Pro Xaa Gly Gly Arg Leu 
    770                 775                 780                 


Glu Val Met Val Arg Ile Arg Glu Pro Leu Xaa Ala Gln Gln Leu Glu 
785                 790                 795                 800 


Xaa Xaa Xaa Glu Arg Trp Leu Val Ile Asp Pro Val Pro Ala Ala Val 
                805                 810                 815     


Pro Xaa Gln Val Ala Gly Pro Lys Gly Lys Ala Pro Pro Val Pro Ala 
            820                 825                 830         


Pro Ala Arg Glu Ser Gly Asn Arg Ser Ala Arg Pro Leu His Ser Leu 
        835                 840                 845             


Ser Val Leu Ala Phe Asp Gln Glu Arg Leu Glu Arg Lys Ile Leu Ala 
    850                 855                 860                 


Leu Arg Gln Ala Arg Arg Pro Val Pro Pro Glu Val Ala Gln Gln Tyr 
865                 870                 875                 880 


Gln Asp Ile Met Gln Arg Ser Gln Trp Gln Arg Ala Gln Leu Glu Gln 
                885                 890                 895     


Gly Gly Val Gly Ile Arg Arg Glu Tyr Ala Ala Gln Leu Glu Arg Gln 
            900                 905                 910         


Leu Gln Phe Tyr Xaa Glu Ala Ala Arg Arg Leu Gly Asn Asp Gly Ser 
        915                 920                 925             


Arg Asp Ala Ala Lys Glu Ala Leu Tyr Arg Arg Asn Leu Val Glu Ser 
    930                 935                 940                 


Glu Leu Gln Arg Leu Arg Arg 
945                 950     


<210> 5171
<211> 378
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<400> 5171
Xaa Gln Ala Gly Asp Ser Ala Lys Met Arg Arg Tyr Asp Arg Gly Leu 
1               5                   10                  15      


Lys Xaa Leu Glu Asn Leu Leu Ala Ser Ile Arg Lys Gly Asn Ala Ile 
            20                  25                  30          


Asp Glu Ala Asp Ile Pro Pro Pro Val Ala Ile Gly Lys Gly Pro Ala 
        35                  40                  45              


Ser Xaa Pro Xaa Tyr Ser Pro Ala Pro Xaa Gln Pro Ala Pro Arg Ile 
    50                  55                  60                  


Ala Ser Ala Pro Glu Pro Arg Val Xaa Leu Glu Gly Pro Ser Ala Xaa 
65                  70                  75                  80  


Ala Pro Ala Ser Ser Pro Gly Leu Ala Lys Pro Gln Met Pro Pro Gly 
                85                  90                  95      


Pro Cys Ser Pro Gly Pro Leu Ala Gln Leu Gln Ser Arg Gln Arg Asp 
            100                 105                 110         


Tyr Lys Leu Ala Ala Leu His Ala Lys Gln Gln Gly Asp Xaa Xaa Ala 
        115                 120                 125             


Ala Ala Arg His Phe Arg Val Ala Lys Ser Phe Asp Ala Val Leu Glu 
    130                 135                 140                 


Ala Leu Ser Arg Gly Glu Pro Val Asp Leu Ser Cys Leu Pro Pro Pro 
145                 150                 155                 160 


Pro Asp Gln Leu Pro Pro Asp Pro Pro Ser Pro Pro Ser Gln Pro Pro 
                165                 170                 175     


Xaa Pro Ala Xaa Ala Pro Ser Xaa Xaa Glu Val Pro Pro Pro Pro Arg 
            180                 185                 190         


Xaa Leu Leu Glu Ala Leu Glu Gln Arg Met Glu Arg Tyr Gln Val Ala 
        195                 200                 205             


Ala Ala Gln Ala Lys Ser Lys Gly Asp Gln Arg Lys Ala Arg Met His 
    210                 215                 220                 


Glu Arg Ile Val Lys Gln Tyr Gln Asp Ala Ile Arg Ala His Lys Ala 
225                 230                 235                 240 


Gly Arg Ala Val Asp Val Ala Glu Leu Pro Val Pro Pro Ala Glu Gln 
                245                 250                 255     


Pro Cys Gly Pro His Ser Pro Ala Gln Ser Pro Xaa Leu Lys Asn Ser 
            260                 265                 270         


Pro Val Gly Ile Ser Pro Asn Ser Gln Ser Ala Pro Gln Ser His Ile 
        275                 280                 285             


His Gln Ser Pro Ala Ala Ala Gly Leu Pro Arg Gly Pro Gln Glu Ala 
    290                 295                 300                 


Ala Pro Ala Gly Arg Xaa Ala Ser Gln Ala Glu Lys Arg Arg Gly Gly 
305                 310                 315                 320 


Cys Gln Asp Ala Pro Ala Pro Ser Gln Gly Xaa Gly Ala Tyr Ala Gly 
                325                 330                 335     


Gly Leu Ala Gln Trp Ala Ala Cys Gly His His Gln Gly Ala Ala Cys 
            340                 345                 350         


Pro Cys Gln Gln Gly Arg Leu Cys Pro Gly Pro Ala Ala Trp Pro Gly 
        355                 360                 365             


Ser Val Ser Gly Gly Arg Pro Ala Leu Trp 
    370                 375             


<210> 5172
<211> 405
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<400> 5172
Xaa Gln Val Pro Pro Ala Pro Val Asn Lys Asp Asp Phe Ala Leu Val 
1               5                   10                  15      


Gln Arg Pro Gly Pro Gly Leu Ser Gln Glu Ala Ala Arg Arg Tyr Gly 
            20                  25                  30          


Glu Leu Xaa Lys Leu Ile Arg Gln Gln His Glu Met Cys Leu Asn His 
        35                  40                  45              


Ser Asn Gln Phe Xaa Gln Leu Gly Asn Ile Xaa Glu Xaa Xaa Lys Phe 
    50                  55                  60                  


Glu Lys Leu Ala Glu Asp Cys Lys Arg Ser Met Asp Ile Leu Lys Gln 
65                  70                  75                  80  


Ala Phe Val Arg Gly Leu Pro Xaa Pro Xaa Ala Arg Phe Glu Gln Arg 
                85                  90                  95      


Xaa Phe Ser Val Ile Lys Ile Phe Pro Asp Leu Ser Ser Asn Asp Met 
            100                 105                 110         


Leu Leu Phe Ile Val Lys Gly Ile Asn Leu Pro Xaa Pro Pro Gly Leu 
        115                 120                 125             


Ser Pro Gly Asp Leu Asp Val Phe Val Arg Phe Asp Phe Pro Tyr Pro 
    130                 135                 140                 


Asn Val Glu Glu Ala Gln Lys Asp Lys Xaa Ser Val Ile Lys Asn Xaa 
145                 150                 155                 160 


Asp Ser Pro Glu Phe Lys Glu Gln Phe Lys Leu Cys Ile Asn Arg Ser 
                165                 170                 175     


His Arg Gly Phe Arg Arg Ala Ile Gln Xaa Lys Gly Ile Lys Phe Glu 
            180                 185                 190         


Val Val His Lys Gly Gly Leu Phe Lys Xaa Asp Arg Val Leu Gly Xaa 
        195                 200                 205             


Ala Gln Leu Lys Leu Asp Ala Leu Glu Ile Ala Cys Glu Val Arg Glu 
    210                 215                 220                 


Ile Leu Glu Val Leu Asp Gly Arg Arg Pro Xaa Gly Gly Arg Leu Glu 
225                 230                 235                 240 


Val Met Val Arg Ile Arg Glu Pro Leu Xaa Ala Gln Gln Leu Glu Xaa 
                245                 250                 255     


Xaa Xaa Glu Arg Trp Leu Val Ile Asp Pro Val Pro Ala Ala Val Pro 
            260                 265                 270         


Xaa Val Ala Gly Pro Lys Gly Lys Ala Pro Pro Val Pro Ala Pro Ala 
        275                 280                 285             


Arg Glu Ser Gly Asn Arg Ser Ala Arg Pro Leu His Ser Leu Ser Val 
    290                 295                 300                 


Leu Ala Phe Asp Gln Glu Arg Leu Glu Arg Lys Ile Leu Ala Leu Arg 
305                 310                 315                 320 


Gln Ala Arg Arg Pro Val Pro Pro Glu Val Ala Gln Gln Tyr Gln Asp 
                325                 330                 335     


Ile Met Gln Arg Ser Gln Trp Gln Arg Ala Gln Leu Glu Gln Gly Gly 
            340                 345                 350         


Val Gly Ile Arg Arg Glu Tyr Ala Ala Gln Leu Glu Arg Gln Leu Gln 
        355                 360                 365             


Phe Tyr Xaa Glu Ala Ala Arg Arg Leu Gly Asn Asp Gly Ser Arg Asp 
    370                 375                 380                 


Ala Ala Lys Glu Ala Leu Tyr Arg Arg Asn Leu Val Glu Ser Glu Leu 
385                 390                 395                 400 


Gln Arg Leu Arg Arg 
                405 


<210> 5173
<211> 852
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<400> 5173
Met Met Pro Gly Pro Arg Pro Arg Lys Gly Pro Gln Ala Arg Gly Gln 
1               5                   10                  15      


Gly Val Ala Ala Ala Lys Gln Met Gly Leu Phe Met Glu Phe Gly Pro 
            20                  25                  30          


Glu Asp Met Leu Leu Gly Met Asp Glu Ala Glu Asp Asp Glu Asp Leu 
        35                  40                  45              


Glu Ala Glu Leu Leu Ala Leu Xaa Gly Glu Ala Gln Xaa Xaa Gly Lys 
    50                  55                  60                  


Lys Pro Ala Pro Lys Gly Gln Ala Pro Leu Pro Met Ala His Ile Glu 
65                  70                  75                  80  


Lys Leu Ala Ala Asp Cys Met Arg Asp Val Glu Glu Glu Glu Glu Glu 
                85                  90                  95      


Glu Gly Leu Glu Glu Asp Ala Glu Leu Leu Xaa Glu Leu Gln Glu Val 
            100                 105                 110         


Leu Gly Val Asp Glu Glu Xaa Glu Pro Leu Asp Gly Asp Glu Val Ala 
        115                 120                 125             


Asp Pro Gly Gly Ser Glu Glu Glu Asn Gly Leu Glu Asp Xaa Glu Pro 
    130                 135                 140                 


Pro Val Gln Xaa Ala Val Leu Xaa Ala Ser Ala Pro Ala Ala Gln Ala 
145                 150                 155                 160 


Gly Ala Ser Gln Gly Leu His Ala Leu Leu Glu Glu Arg Ile His Asn 
                165                 170                 175     


Tyr Arg Glu Ala Ala Ala Ser Ala Lys Glu Ala Gly Glu Ala Ala Lys 
            180                 185                 190         


Ala Arg Arg Cys Glu Arg Gly Leu Lys Xaa Leu Glu Ser Gln Leu Ala 
        195                 200                 205             


Ser Val Arg Arg Gly Arg Lys Ile Asn Glu Asp Glu Ile Pro Pro Pro 
    210                 215                 220                 


Val Ala Leu Gly Lys Arg Pro Leu Ala Pro Gln Glu Pro Ala Asn Arg 
225                 230                 235                 240 


Ser Pro Glu Xaa Asp Pro Pro Ala Pro Pro Ala Leu Glu Ser Asp Asn 
                245                 250                 255     


Pro Ser Gln Pro Glu Xaa Ser Leu Pro Gly Ile Ser Ala Gln Pro Val 
            260                 265                 270         


Ser Asp Leu Asp Pro Asp Pro Arg Ala Leu Leu Ser Ser Arg Gln Arg 
        275                 280                 285             


Glu Tyr Lys Val Ala Ala Leu Ser Ala Lys Arg Ala Gly Glu Leu Asp 
    290                 295                 300                 


Arg Ala Arg Glu Leu Met Arg Ile Gly Lys Arg Phe Gly Ala Val Leu 
305                 310                 315                 320 


Glu Ala Leu Glu Lys Gly Gln Pro Val Asp Leu Ser Ala Met Pro Pro 
                325                 330                 335     


Ala Pro Glu Asp Leu Lys Pro Gln Gln Ala Ser Gln Ala Pro Xaa Ala 
            340                 345                 350         


Pro Ser Val Ile Pro Pro Ala Val Glu Arg Val Gln Pro Val Met Ala 
        355                 360                 365             


Pro Asp Val Pro Ala Xaa Pro Val Ala Pro Xaa Glu Ser Gln Xaa Val 
    370                 375                 380                 


Leu Asp Ala Leu Gln Gln Arg Leu Asn Lys Tyr Arg Glu Ala Gly Ile 
385                 390                 395                 400 


Gln Ala Arg Ser Gly Gly Asp Glu Arg Lys Ala Arg Met His Glu Arg 
                405                 410                 415     


Ile Ala Lys Gln Tyr Gln Asp Ala Ile Arg Ala His Arg Ala Gly Arg 
            420                 425                 430         


Lys Val Asn Phe Ala Glu Leu Pro Val Pro Pro Gly Phe Pro Pro Ile 
        435                 440                 445             


Pro Gly Leu Glu Ser Xaa Met Gly Val Glu Glu Asp Ala Val Ala Ala 
    450                 455                 460                 


Xaa Leu Ala Ala Ala Glu Lys Leu Ala Ser Ala Glu Asp Ser Ala Pro 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Asp Glu Gly Glu Pro Pro Ala Gln Ala Pro Val 
                485                 490                 495     


Ala Lys Lys Pro Ala Arg Pro Xaa Val Pro Ser Ser Gln Arg Leu Pro 
            500                 505                 510         


Glu Pro Arg Ala Ser Ser Ser Lys Glu Ser Pro Ser Pro Ser Val Arg 
        515                 520                 525             


Glu Gln Leu Ala Leu Leu Glu Ala Arg Lys Leu Gln Tyr Gln Arg Ala 
    530                 535                 540                 


Ala Leu Gln Ala Lys Arg Ser Gln Asp Leu Glu Gln Ala Lys Ala Tyr 
545                 550                 555                 560 


Leu Arg Val Ala Lys Trp Leu Glu Ala Gln Ile Ile Gln Ala Arg Ser 
                565                 570                 575     


Gly Arg Pro Val Asp Leu Ser Lys Val Pro Ser Pro Leu Xaa Asp Glu 
            580                 585                 590         


Glu Gly Asp Phe Ile Leu Ile His His Glu Asp Leu Arg Leu Ser Gln 
        595                 600                 605             


Lys Ala Glu Glu Val Tyr Ala Gln Leu Gln Lys Met Leu Leu Glu Gln 
    610                 615                 620                 


Gln Glu Lys Cys Leu Leu Phe Ser Lys Gln Phe Met His Gln Gly Asn 
625                 630                 635                 640 


Val Ala Glu Xaa Xaa Arg Phe Glu Lys Leu Ala Gln Asp Arg Lys Lys 
                645                 650                 655     


Gln Leu Glu Ile Leu Gln Leu Ala Gln Ala Gln Gly Leu Asp Pro Pro 
            660                 665                 670         


Xaa His His Phe Glu Leu Lys Xaa Phe Gln Xaa Val Arg Ile Phe Ser 
        675                 680                 685             


Glu Leu Asn Ser Xaa Glu Met His Leu Ile Ile Val Arg Gly Met Asn 
    690                 695                 700                 


Leu Pro Ala Pro Pro Gly Val Xaa Pro Asp Asp Leu Asp Ala Phe Val 
705                 710                 715                 720 


Arg Phe Glu Phe His Tyr Pro Asn Ser Asp Gln Ala Gln Lys Ser Lys 
                725                 730                 735     


Xaa Ala Val Val Lys Asn Xaa Asn Ser Pro Glu Phe Asp Gln Leu Phe 
            740                 745                 750         


Lys Leu Asn Ile Asn Arg Asn His Arg Gly Phe Lys Arg Val Ile Gln 
        755                 760                 765             


Ser Lys Gly Ile Lys Phe Glu Ile Phe His Lys Gly Ser Phe Phe Arg 
    770                 775                 780                 


Ser Asp Lys Leu Val Gly Xaa Ala His Leu Lys Leu Glu Arg Leu Glu 
785                 790                 795                 800 


Asn Glu Cys Glu Ile Arg Glu Ile Val Glu Val Leu Asp Gly Arg Lys 
                805                 810                 815     


Pro Xaa Gly Gly Lys Leu Glu Val Lys Val Arg Leu Arg Glu Pro Leu 
            820                 825                 830         


Ser Gly Gln Asp Val Gln Met Val Xaa Glu Asn Trp Leu Val Leu Glu 
        835                 840                 845             


Pro Arg Gly Leu 
    850         


<210> 5174
<211> 858
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<400> 5174
Met Met Pro Gly Pro Arg Pro Arg Lys Gly Pro Gln Ala Arg Gly Gln 
1               5                   10                  15      


Gly Val Ala Ala Ala Lys Gln Met Gly Leu Phe Met Glu Phe Gly Pro 
            20                  25                  30          


Glu Asp Met Leu Leu Gly Met Asp Glu Ala Glu Asp Asp Glu Asp Leu 
        35                  40                  45              


Glu Ala Glu Leu Leu Ala Leu Xaa Gly Glu Ala Gln Xaa Xaa Gly Lys 
    50                  55                  60                  


Lys Pro Ala Pro Lys Gly Gln Ala Pro Leu Pro Met Ala His Ile Glu 
65                  70                  75                  80  


Lys Leu Ala Ala Asp Cys Met Arg Asp Val Glu Glu Glu Glu Glu Glu 
                85                  90                  95      


Glu Gly Leu Glu Glu Asp Ala Glu Leu Leu Xaa Glu Leu Gln Glu Val 
            100                 105                 110         


Leu Gly Val Asp Glu Glu Xaa Glu Pro Leu Asp Gly Asp Glu Val Ala 
        115                 120                 125             


Asp Pro Gly Gly Ser Glu Glu Glu Asn Gly Leu Glu Asp Xaa Glu Pro 
    130                 135                 140                 


Pro Val Gln Xaa Ala Val Leu Xaa Ala Ser Ala Pro Ala Ala Gln Ala 
145                 150                 155                 160 


Gly Ala Ser Gln Gly Leu His Ala Leu Leu Glu Glu Arg Ile His Asn 
                165                 170                 175     


Tyr Arg Glu Ala Ala Ala Ser Ala Lys Glu Ala Gly Glu Ala Ala Lys 
            180                 185                 190         


Ala Arg Arg Cys Glu Arg Gly Leu Lys Xaa Leu Glu Ser Gln Leu Ala 
        195                 200                 205             


Ser Val Arg Arg Gly Arg Lys Ile Asn Glu Asp Glu Ile Pro Pro Pro 
    210                 215                 220                 


Val Ala Leu Gly Lys Arg Pro Leu Ala Pro Gln Glu Pro Ala Asn Arg 
225                 230                 235                 240 


Ser Pro Glu Xaa Asp Pro Pro Ala Pro Pro Ala Leu Glu Ser Asp Asn 
                245                 250                 255     


Pro Ser Gln Pro Glu Xaa Ser Leu Pro Gly Ile Ser Ala Gln Pro Val 
            260                 265                 270         


Ser Asp Leu Asp Pro Asp Pro Arg Ala Leu Leu Ser Ser Arg Gln Arg 
        275                 280                 285             


Glu Tyr Lys Val Ala Ala Leu Ser Ala Lys Arg Ala Gly Glu Leu Asp 
    290                 295                 300                 


Arg Ala Arg Glu Leu Met Arg Ile Gly Lys Arg Phe Gly Ala Val Leu 
305                 310                 315                 320 


Glu Ala Leu Glu Lys Gly Gln Pro Val Asp Leu Ser Ala Met Pro Pro 
                325                 330                 335     


Ala Pro Glu Asp Leu Lys Pro Gln Gln Ala Ser Gln Ala Pro Xaa Ala 
            340                 345                 350         


Pro Ser Val Ile Pro Pro Ala Val Glu Arg Val Gln Pro Val Met Ala 
        355                 360                 365             


Pro Asp Val Pro Ala Xaa Pro Val Ala Pro Xaa Glu Ser Gln Xaa Val 
    370                 375                 380                 


Leu Asp Ala Leu Gln Gln Arg Leu Asn Lys Tyr Arg Glu Ala Gly Ile 
385                 390                 395                 400 


Gln Ala Arg Ser Gly Gly Asp Glu Arg Lys Ala Arg Met His Glu Arg 
                405                 410                 415     


Ile Ala Lys Gln Tyr Gln Asp Ala Ile Arg Ala His Arg Ala Gly Arg 
            420                 425                 430         


Lys Val Asn Phe Ala Glu Leu Pro Val Pro Pro Gly Phe Pro Pro Ile 
        435                 440                 445             


Pro Gly Leu Glu Ser Xaa Met Gly Val Glu Glu Asp Ala Val Ala Ala 
    450                 455                 460                 


Xaa Leu Ala Ala Ala Glu Lys Leu Ala Ser Ala Glu Asp Ser Ala Pro 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Asp Glu Pro Pro Gly His Leu Gln Gly Glu Pro 
                485                 490                 495     


Pro Ala Gln Ala Pro Val Ala Lys Lys Pro Ala Arg Pro Xaa Val Pro 
            500                 505                 510         


Ser Ser Gln Arg Leu Pro Glu Pro Arg Ala Ser Ser Ser Lys Glu Ser 
        515                 520                 525             


Pro Ser Pro Ser Val Arg Glu Gln Leu Ala Leu Leu Glu Ala Arg Lys 
    530                 535                 540                 


Leu Gln Tyr Gln Arg Ala Ala Leu Gln Ala Lys Arg Ser Gln Asp Leu 
545                 550                 555                 560 


Glu Gln Ala Lys Ala Tyr Leu Arg Val Ala Lys Trp Leu Glu Ala Gln 
                565                 570                 575     


Ile Ile Gln Ala Arg Ser Gly Arg Pro Val Asp Leu Ser Lys Val Pro 
            580                 585                 590         


Ser Pro Leu Xaa Asp Glu Glu Gly Asp Phe Ile Leu Ile His His Glu 
        595                 600                 605             


Asp Leu Arg Leu Ser Gln Lys Ala Glu Glu Val Tyr Ala Gln Leu Gln 
    610                 615                 620                 


Lys Met Leu Leu Glu Gln Gln Glu Lys Cys Leu Leu Phe Ser Lys Gln 
625                 630                 635                 640 


Phe Met His Gln Gly Asn Val Ala Glu Xaa Xaa Arg Phe Glu Lys Leu 
                645                 650                 655     


Ala Gln Asp Arg Lys Lys Gln Leu Glu Ile Leu Gln Leu Ala Gln Ala 
            660                 665                 670         


Gln Gly Leu Asp Pro Pro Xaa His His Phe Glu Leu Lys Xaa Phe Gln 
        675                 680                 685             


Xaa Val Arg Ile Phe Ser Glu Leu Asn Ser Xaa Glu Met His Leu Ile 
    690                 695                 700                 


Ile Val Arg Gly Met Asn Leu Pro Ala Pro Pro Gly Val Xaa Pro Asp 
705                 710                 715                 720 


Asp Leu Asp Ala Phe Val Arg Phe Glu Phe His Tyr Pro Asn Ser Asp 
                725                 730                 735     


Gln Ala Gln Lys Ser Lys Xaa Ala Val Val Lys Asn Xaa Asn Ser Pro 
            740                 745                 750         


Glu Phe Asp Gln Leu Phe Lys Leu Asn Ile Asn Arg Asn His Arg Gly 
        755                 760                 765             


Phe Lys Arg Val Ile Gln Ser Lys Gly Ile Lys Phe Glu Ile Phe His 
    770                 775                 780                 


Lys Gly Ser Phe Phe Arg Ser Asp Lys Leu Val Gly Xaa Ala His Leu 
785                 790                 795                 800 


Lys Leu Glu Arg Leu Glu Asn Glu Cys Glu Ile Arg Glu Ile Val Glu 
                805                 810                 815     


Val Leu Asp Gly Arg Lys Pro Xaa Gly Gly Lys Leu Glu Val Lys Val 
            820                 825                 830         


Arg Leu Arg Glu Pro Leu Ser Gly Gln Asp Val Gln Met Val Xaa Glu 
        835                 840                 845             


Asn Trp Leu Val Leu Glu Pro Arg Gly Leu 
    850                 855             


<210> 5175
<211> 672
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<400> 5175
Xaa Gly Ala Ser Gln Gly Leu His Ala Leu Leu Glu Glu Arg Ile His 
1               5                   10                  15      


Asn Tyr Arg Glu Ala Ala Ala Ser Ala Lys Glu Ala Gly Glu Ala Ala 
            20                  25                  30          


Lys Ala Arg Arg Cys Glu Arg Gly Leu Lys Xaa Leu Glu Ser Gln Leu 
        35                  40                  45              


Ala Ser Val Arg Arg Gly Arg Lys Ile Asn Glu Asp Glu Ile Pro Pro 
    50                  55                  60                  


Pro Val Ala Leu Gly Lys Arg Pro Leu Ala Pro Gln Glu Pro Ala Asn 
65                  70                  75                  80  


Arg Ser Pro Glu Xaa Asp Pro Pro Ala Pro Pro Ala Leu Glu Ser Asp 
                85                  90                  95      


Pro Asp Pro Arg Ala Leu Leu Ser Ser Arg Gln Arg Glu Tyr Lys Val 
            100                 105                 110         


Ala Ala Leu Ser Ala Lys Arg Ala Gly Glu Leu Asp Arg Ala Arg Glu 
        115                 120                 125             


Leu Met Arg Ile Gly Lys Arg Phe Gly Ala Val Leu Glu Ala Leu Glu 
    130                 135                 140                 


Lys Gly Gln Pro Val Asp Leu Ser Ala Met Pro Pro Ala Pro Glu Asp 
145                 150                 155                 160 


Leu Lys Pro Gln Gln Ala Ser Gln Ala Pro Xaa Ala Pro Ser Val Ile 
                165                 170                 175     


Pro Pro Ala Val Glu Arg Val Gln Pro Val Met Ala Pro Asp Val Pro 
            180                 185                 190         


Ala Xaa Pro Val Ala Pro Xaa Glu Ser Gln Xaa Val Leu Asp Ala Leu 
        195                 200                 205             


Gln Gln Arg Leu Asn Lys Tyr Arg Glu Ala Gly Ile Gln Ala Arg Ser 
    210                 215                 220                 


Gly Gly Asp Glu Arg Lys Ala Arg Met His Glu Arg Ile Ala Lys Gln 
225                 230                 235                 240 


Tyr Gln Asp Ala Ile Arg Ala His Arg Ala Gly Arg Lys Val Asn Phe 
                245                 250                 255     


Ala Glu Leu Pro Val Pro Pro Gly Phe Pro Pro Ile Pro Gly Leu Glu 
            260                 265                 270         


Ser Xaa Met Gly Val Glu Glu Asp Ala Val Ala Ala Xaa Leu Ala Ala 
        275                 280                 285             


Ala Glu Lys Leu Ala Ser Ala Glu Asp Ser Ala Pro Ala Asp Lys Asp 
    290                 295                 300                 


Glu Asp Glu Gly Glu Pro Pro Ala Gln Ala Pro Val Ala Lys Lys Pro 
305                 310                 315                 320 


Ala Arg Pro Xaa Val Pro Ser Ser Gln Arg Leu Pro Glu Pro Arg Ala 
                325                 330                 335     


Ser Ser Ser Lys Glu Ser Pro Ser Pro Ser Val Arg Glu Gln Leu Ala 
            340                 345                 350         


Leu Leu Glu Ala Arg Lys Leu Gln Tyr Gln Arg Ala Ala Leu Gln Ala 
        355                 360                 365             


Lys Arg Ser Gln Asp Leu Glu Gln Ala Lys Ala Tyr Leu Arg Val Ala 
    370                 375                 380                 


Lys Trp Leu Glu Ala Gln Ile Ile Gln Ala Arg Ser Gly Arg Pro Val 
385                 390                 395                 400 


Asp Leu Ser Lys Val Pro Ser Pro Leu Xaa Asp Glu Glu Gly Asp Phe 
                405                 410                 415     


Ile Leu Ile His His Glu Asp Leu Arg Leu Ser Gln Lys Ala Glu Glu 
            420                 425                 430         


Val Tyr Ala Gln Leu Gln Lys Met Leu Leu Glu Gln Gln Glu Lys Cys 
        435                 440                 445             


Leu Leu Phe Ser Lys Gln Phe Met His Gln Gly Asn Val Ala Glu Xaa 
    450                 455                 460                 


Xaa Arg Phe Glu Lys Leu Ala Gln Asp Arg Lys Lys Gln Leu Glu Ile 
465                 470                 475                 480 


Leu Gln Leu Ala Gln Ala Gln Gly Leu Asp Pro Pro Xaa His His Phe 
                485                 490                 495     


Glu Leu Lys Xaa Phe Gln Xaa Val Arg Ile Phe Ser Glu Leu Asn Ser 
            500                 505                 510         


Xaa Glu Met His Leu Ile Ile Val Arg Gly Met Asn Leu Pro Ala Pro 
        515                 520                 525             


Pro Gly Val Xaa Pro Asp Asp Leu Asp Ala Phe Val Arg Phe Glu Phe 
    530                 535                 540                 


His Tyr Pro Asn Ser Asp Gln Ala Gln Lys Ser Lys Xaa Ala Val Val 
545                 550                 555                 560 


Lys Asn Xaa Asn Ser Pro Glu Phe Asp Gln Leu Phe Lys Leu Asn Ile 
                565                 570                 575     


Asn Arg Asn His Arg Gly Phe Lys Arg Val Ile Gln Ser Lys Gly Ile 
            580                 585                 590         


Lys Phe Glu Ile Phe His Lys Gly Ser Phe Phe Arg Ser Asp Lys Leu 
        595                 600                 605             


Val Gly Xaa Ala His Leu Lys Leu Glu Arg Leu Glu Asn Glu Cys Glu 
    610                 615                 620                 


Ile Arg Glu Ile Val Glu Val Leu Asp Gly Arg Lys Pro Xaa Gly Gly 
625                 630                 635                 640 


Lys Leu Glu Val Lys Val Arg Leu Arg Glu Pro Leu Ser Gly Gln Asp 
                645                 650                 655     


Val Gln Met Val Xaa Glu Asn Trp Leu Val Leu Glu Pro Arg Gly Leu 
            660                 665                 670         


<210> 5176
<211> 628
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<400> 5176
Xaa Lys Ile Asn Glu Asp Glu Ile Pro Pro Pro Val Ala Leu Gly Lys 
1               5                   10                  15      


Arg Pro Leu Ala Pro Gln Glu Pro Ala Asn Arg Ser Pro Glu Xaa Asp 
            20                  25                  30          


Pro Pro Ala Pro Pro Ala Leu Glu Ser Asp Asn Pro Ser Gln Pro Glu 
        35                  40                  45              


Xaa Ser Leu Pro Gly Ile Ser Ala Gln Pro Val Ser Asp Leu Asp Pro 
    50                  55                  60                  


Asp Pro Arg Ala Leu Leu Ser Ser Arg Gln Arg Glu Tyr Lys Val Ala 
65                  70                  75                  80  


Ala Leu Ser Ala Lys Arg Ala Gly Glu Leu Asp Arg Ala Arg Glu Leu 
                85                  90                  95      


Met Arg Ile Gly Lys Arg Phe Gly Ala Val Leu Glu Ala Leu Glu Lys 
            100                 105                 110         


Gly Gln Pro Val Asp Leu Ser Ala Met Pro Pro Ala Pro Glu Asp Leu 
        115                 120                 125             


Lys Pro Gln Gln Ala Ser Gln Ala Pro Xaa Ala Pro Ser Val Ile Pro 
    130                 135                 140                 


Pro Ala Val Glu Arg Val Gln Pro Val Met Ala Pro Asp Val Pro Ala 
145                 150                 155                 160 


Xaa Pro Val Ala Pro Xaa Glu Ser Gln Xaa Val Leu Asp Ala Leu Gln 
                165                 170                 175     


Gln Arg Leu Asn Lys Tyr Arg Glu Ala Gly Ile Gln Ala Arg Ser Gly 
            180                 185                 190         


Gly Asp Glu Arg Lys Ala Arg Met His Glu Arg Ile Ala Lys Gln Tyr 
        195                 200                 205             


Gln Asp Ala Ile Arg Ala His Arg Ala Gly Arg Lys Val Asn Phe Ala 
    210                 215                 220                 


Glu Leu Pro Val Pro Pro Gly Phe Pro Pro Ile Pro Gly Leu Glu Ser 
225                 230                 235                 240 


Xaa Met Gly Val Glu Glu Asp Ala Val Ala Ala Xaa Leu Ala Ala Ala 
                245                 250                 255     


Glu Lys Leu Ala Ser Ala Glu Asp Ser Ala Pro Ala Asp Lys Asp Glu 
            260                 265                 270         


Asp Glu Gly Glu Pro Pro Ala Gln Ala Pro Val Ala Lys Lys Pro Ala 
        275                 280                 285             


Arg Pro Xaa Val Pro Ser Ser Gln Arg Leu Pro Glu Pro Arg Ala Ser 
    290                 295                 300                 


Ser Ser Lys Glu Ser Pro Ser Pro Ser Val Arg Glu Gln Leu Ala Leu 
305                 310                 315                 320 


Leu Glu Ala Arg Lys Leu Gln Tyr Gln Arg Ala Ala Leu Gln Ala Lys 
                325                 330                 335     


Arg Ser Gln Asp Leu Glu Gln Ala Lys Ala Tyr Leu Arg Val Ala Lys 
            340                 345                 350         


Trp Leu Glu Ala Gln Ile Ile Gln Ala Arg Ser Gly Arg Pro Val Asp 
        355                 360                 365             


Leu Ser Lys Val Pro Ser Pro Leu Xaa Asp Glu Glu Gly Asp Phe Ile 
    370                 375                 380                 


Leu Ile His His Glu Asp Leu Arg Leu Ser Gln Lys Ala Glu Glu Val 
385                 390                 395                 400 


Tyr Ala Gln Leu Gln Lys Met Leu Leu Glu Gln Gln Glu Lys Cys Leu 
                405                 410                 415     


Leu Phe Ser Lys Gln Phe Met His Gln Gly Asn Val Ala Glu Xaa Xaa 
            420                 425                 430         


Arg Phe Glu Lys Leu Ala Gln Asp Arg Lys Lys Gln Leu Glu Ile Leu 
        435                 440                 445             


Gln Leu Ala Gln Ala Gln Gly Leu Asp Pro Pro Xaa His His Phe Glu 
    450                 455                 460                 


Leu Lys Xaa Phe Gln Xaa Val Arg Ile Phe Ser Glu Leu Asn Ser Xaa 
465                 470                 475                 480 


Glu Met His Leu Ile Ile Val Arg Gly Met Asn Leu Pro Ala Pro Pro 
                485                 490                 495     


Gly Val Xaa Pro Asp Asp Leu Asp Ala Phe Val Arg Phe Glu Phe His 
            500                 505                 510         


Tyr Pro Asn Ser Asp Gln Ala Gln Lys Ser Lys Xaa Ala Val Val Lys 
        515                 520                 525             


Asn Xaa Asn Ser Pro Glu Phe Asp Gln Leu Phe Lys Leu Asn Ile Asn 
    530                 535                 540                 


Arg Asn His Arg Gly Phe Lys Arg Val Ile Gln Ser Lys Gly Ile Lys 
545                 550                 555                 560 


Phe Glu Ile Phe His Lys Gly Ser Phe Phe Arg Ser Asp Lys Leu Val 
                565                 570                 575     


Gly Xaa Ala His Leu Lys Leu Glu Arg Leu Glu Asn Glu Cys Glu Ile 
            580                 585                 590         


Arg Glu Ile Val Glu Val Leu Asp Gly Arg Lys Pro Xaa Gly Gly Lys 
        595                 600                 605             


Leu Glu Val Lys Pro Met Ala Ser Xaa Arg Arg Gly Val Arg Pro Arg 
    610                 615                 620                 


Leu Cys Arg Arg 
625             


<210> 5177
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<400> 5177
Lys Pro Xaa Pro Phe Ser Arg Ala Cys Trp Gln Ile Leu Pro His Leu 
1               5                   10                  15      


Ser Ala Gly Val Pro Leu Leu Gly Trp Glu His Pro Val Gln Gly Lys 
            20                  25                  30          


Ser Phe Gln Ala Xaa Asn Cys Cys Pro Gln Gly Asn Gly Val Arg Lys 
        35                  40                  45              


Ile Pro Pro Trp Gln Pro Pro Gly Ala Cys Ala Gly Gly Ala Gln Asp 
    50                  55                  60                  


Pro Pro Pro Glu Tyr Asp Ser Pro Glu Arg Pro Xaa Glu Leu Xaa Ser 
65                  70                  75                  80  


Asn Ser Phe Asn Phe Gln Asn Arg Leu Cys Arg Ile Phe His Glu Gly 
                85                  90                  95      


Xaa His Glu Gly Glu Ile Ala Ser Ser Glu Val Gln Ser Arg Lys Cys 
            100                 105                 110         


Ile Ala Ala Gly Asn Pro His Ser Ser Ala Gln Xaa Leu Xaa Lys Ser 
        115                 120                 125             


Gln 
    


<210> 5178
<211> 73
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<400> 5178
Met Asn Pro Arg Glu Glu Lys Val Lys Ile Ile Xaa Glu Glu Phe Ile 
1               5                   10                  15      


Glu Asn Asp Glu Asp Ala Asp Met Gly Arg Gln Asn Lys Asn Ser Lys 
            20                  25                  30          


Val Arg Arg Gln Pro Arg Lys Lys Gln Ala Glu Ala Asn Ser Phe Leu 
        35                  40                  45              


Pro Ser Leu Leu Ala Asp Pro Pro Pro Pro Leu Arg Arg Ser Ser Pro 
    50                  55                  60                  


Pro Arg Leu Gly Ala Ser Arg Ala Gly 
65                  70              


<210> 5179
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 5179
Met Asn Pro Arg Glu Glu Lys Val Lys Ile Ile Xaa Glu Glu Phe Ile 
1               5                   10                  15      


Glu Asn Asp Glu Asp Ala Asp Met Gly Arg Gln Asn Lys Asn Ser Lys 
            20                  25                  30          


Val Arg Arg Gln Pro Arg Lys Lys Gln Lys Pro Xaa Pro Phe Ser Arg 
        35                  40                  45              


Ala Cys Trp Gln Ile Leu Pro His Leu Ser Ala Gly Val Pro Leu Leu 
    50                  55                  60                  


Gly Trp Glu His Pro Val Gln Gly Lys Ser Phe Gln Ala Xaa Asn Cys 
65                  70                  75                  80  


Cys Pro Gln Gly Asn Gly Val Arg Lys Ile Pro Pro Trp Gln Pro Pro 
                85                  90                  95      


Gly Ala Cys Ala Gly Gly Ala Gln Asp Pro Pro Pro Glu Tyr Asp Ser 
            100                 105                 110         


Pro Glu Arg Pro Xaa Glu Arg Ala Gly Cys 
        115                 120         


<210> 5180
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<400> 5180
Met Asn Pro Arg Glu Glu Lys Val Lys Ile Ile Xaa Glu Glu Phe Ile 
1               5                   10                  15      


Glu Asn Asp Glu Asp Ala Asp Met Gly Arg Gln Asn Lys Asn Ser Lys 
            20                  25                  30          


Val Arg Arg Gln Pro Arg Lys Lys Gln Pro Pro Xaa Ala Val Pro Lys 
        35                  40                  45              


Glu Met Val Ser Glu Lys Ser His Leu Gly Asn Pro Gln Glu Pro Val 
    50                  55                  60                  


Gln Glu Glu Pro Lys Xaa Arg Leu Leu Ser Met Xaa Val Arg Arg Gly 
65                  70                  75                  80  


Pro Arg Arg Glu Leu Val Val Lys Lys Ser Leu Gly Arg Pro Gly Xaa 
                85                  90                  95      


Val Xaa His Val Cys Asn Pro Ser Xaa Leu Glu Gly Arg Gly Gly 
            100                 105                 110     


<210> 5181
<211> 588
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<400> 5181
Met Asn Pro Arg Glu Glu Lys Val Lys Ile Ile Xaa Glu Glu Phe Ile 
1               5                   10                  15      


Glu Asn Asp Glu Asp Ala Asp Met Gly Arg Gln Asn Lys Asn Ser Lys 
            20                  25                  30          


Val Arg Arg Gln Pro Arg Lys Lys Gln Pro Pro Xaa Ala Val Pro Lys 
        35                  40                  45              


Glu Met Val Ser Glu Lys Ser His Leu Gly Asn Pro Gln Glu Pro Val 
    50                  55                  60                  


Gln Glu Glu Pro Lys Xaa Arg Leu Leu Ser Met Xaa Val Arg Arg Gly 
65                  70                  75                  80  


Pro Arg Ser Leu Pro Pro Ile Pro Ser Xaa Ser Arg Xaa Gly Phe Ala 
                85                  90                  95      


Glu Phe Ser Met Arg Gly Arg Met Arg Glu Lys Leu Gln Ala Ala Arg 
            100                 105                 110         


Ser Lys Ala Glu Ser Ala Leu Leu Gln Glu Ile Pro Xaa Pro Arg Pro 
        115                 120                 125             


Arg Arg Leu Arg Ser Pro Ser Lys Lys Glu Leu Glu Xaa Glu Phe Gly 
    130                 135                 140                 


Xaa Glu Pro Gly Lys Glu Val Glu Arg Xaa Gln Gln Glu Val Asp Ser 
145                 150                 155                 160 


Gln Ser Tyr Ser Arg Val Lys Phe His Asp Ser Ala Arg Lys Ile Lys 
                165                 170                 175     


Pro Lys Pro Gln Val Pro Pro Gly Phe Pro Ser Ala Glu Glu Ala Tyr 
            180                 185                 190         


Asn Phe Phe Xaa Phe Asn Phe Asp Pro Glu Pro Glu Gly Ser Glu Glu 
        195                 200                 205             


Lys Pro Lys Ala Arg His Arg Ala Gly Xaa Asn Gln Glu Glu Glu Glu 
    210                 215                 220                 


Gly Glu Glu Glu Glu Pro Pro Ala Gln Gly Gly Gly Lys Glu Met Asp 
225                 230                 235                 240 


Glu Glu Glu Leu Leu Asn Gly Asp Asp Ala Glu Asp Phe Leu Leu Gly 
                245                 250                 255     


Leu Asp His Val Ala Asp Asp Phe Val Ala Val Arg Pro Ala Asp Tyr 
            260                 265                 270         


Glu Ser Ile His Asp Arg Leu Gln Met Glu Arg Glu Met Leu Phe Ile 
        275                 280                 285             


Pro Ser Arg Gln Xaa Val Pro Xaa Tyr Lys Lys Leu Pro Glu Asn Val 
    290                 295                 300                 


Gln Pro Arg Phe Leu Glu Asp Glu Gly Leu Tyr Xaa Gly Val Arg Pro 
305                 310                 315                 320 


Glu Val Ala Arg Xaa Asn Gln Asn Ile Met Glu Asn Arg Leu Leu Met 
                325                 330                 335     


Gln Asp Pro Glu Arg Arg Trp Phe Gly Asp Asp Gly Arg Ile Leu Ala 
            340                 345                 350         


Leu Pro Asn Pro Ile Lys Pro Phe Pro Ser Arg Pro Pro Val Leu Xaa 
        355                 360                 365             


Gln Glu Gln Ser Ile Lys Ala Glu Leu Glu Xaa Leu Tyr Lys Lys Ala 
    370                 375                 380                 


Val Lys Tyr Val His Ser Ser Gln His Val Ile Arg Ser Gly Asp Pro 
385                 390                 395                 400 


Pro Gly Asn Phe Gln Leu Asp Ile Asp Ile Ser Gly Leu Ile Phe Xaa 
                405                 410                 415     


His His Pro Cys Phe Ser Arg Glu His Val Leu Ala Ala Lys Leu Ala 
            420                 425                 430         


Gln Leu Tyr Asp Gln Tyr Leu Ala Arg His Gln Arg Asn Lys Ala Lys 
        435                 440                 445             


Phe Leu Xaa Asp Lys Leu Gln Ala Leu Arg Asn Ala Val Gln Xaa Gly 
    450                 455                 460                 


Leu Asp Pro Glu Lys Pro His Gln Ser Leu Asp Xaa Ile Gln Lys Xaa 
465                 470                 475                 480 


Ile Asn Glu Tyr Lys Ser Glu Ile Arg Gln Xaa Arg Lys Phe Arg Asp 
                485                 490                 495     


Ala Glu Gln Glu Lys Asp Arg Xaa Leu Leu Lys Xaa Ile Ile Lys Val 
            500                 505                 510         


Trp Lys Glu Met Lys Ser Leu Arg Glu Phe Gln Arg Phe Xaa Asn Xaa 
        515                 520                 525             


Pro Leu Lys Leu Val Leu Arg Lys Glu Lys Ala Asp Gln Lys Ala Asp 
    530                 535                 540                 


Glu Glu Ala Tyr Glu Ala Glu Ile Gln Ala Glu Ile Ser Glu Leu Leu 
545                 550                 555                 560 


Glu Glu His Xaa Glu Glu Tyr Ala Gln Lys Met Glu Glu Tyr Arg Xaa 
                565                 570                 575     


Ser Leu Gln Gln Trp Lys Ala Trp Arg Lys Val Gln 
            580                 585             


<210> 5182
<211> 1620
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1083)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1176)..(1176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1243)..(1243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1270)..(1270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1297)..(1297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1324)..(1324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1353)..(1353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1396)..(1396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1517)..(1517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1524)..(1524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1526)..(1526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1581)..(1581)
<223> Selenocysteine

<400> 5182
Met Asn Pro Arg Glu Glu Lys Val Lys Ile Ile Xaa Glu Glu Phe Ile 
1               5                   10                  15      


Glu Asn Asp Glu Asp Ala Asp Met Gly Arg Gln Asn Lys Asn Ser Lys 
            20                  25                  30          


Val Arg Arg Gln Pro Arg Lys Lys Gln Pro Pro Xaa Ala Val Pro Lys 
        35                  40                  45              


Glu Met Val Ser Glu Lys Ser His Leu Gly Asn Pro Gln Glu Pro Val 
    50                  55                  60                  


Gln Glu Glu Pro Lys Xaa Arg Leu Leu Ser Met Xaa Val Arg Arg Gly 
65                  70                  75                  80  


Pro Arg Ser Leu Pro Pro Ile Pro Ser Xaa Ser Arg Xaa Gly Phe Ala 
                85                  90                  95      


Glu Phe Ser Met Arg Gly Arg Met Arg Glu Lys Leu Gln Ala Ala Arg 
            100                 105                 110         


Ser Lys Ala Glu Ser Ala Leu Leu Gln Glu Ile Pro Xaa Pro Arg Pro 
        115                 120                 125             


Arg Arg Leu Arg Ser Pro Ser Lys Lys Glu Leu Glu Xaa Glu Phe Gly 
    130                 135                 140                 


Xaa Glu Pro Gly Lys Glu Val Glu Arg Xaa Gln Gln Glu Val Asp Ser 
145                 150                 155                 160 


Gln Ser Tyr Ser Arg Val Lys Phe His Asp Ser Ala Arg Lys Ile Lys 
                165                 170                 175     


Pro Lys Pro Gln Val Pro Pro Gly Phe Pro Ser Ala Glu Glu Ala Tyr 
            180                 185                 190         


Asn Phe Phe Xaa Phe Asn Phe Asp Pro Glu Pro Glu Gly Ser Glu Glu 
        195                 200                 205             


Lys Pro Lys Ala Arg His Arg Ala Gly Xaa Asn Gln Glu Glu Glu Glu 
    210                 215                 220                 


Gly Glu Glu Glu Glu Pro Pro Ala Gln Gly Gly Gly Lys Glu Met Asp 
225                 230                 235                 240 


Glu Glu Glu Leu Leu Asn Gly Asp Asp Ala Glu Asp Phe Leu Leu Gly 
                245                 250                 255     


Leu Asp His Val Ala Asp Asp Phe Val Ala Val Arg Pro Ala Asp Tyr 
            260                 265                 270         


Glu Ser Ile His Asp Arg Leu Gln Met Glu Arg Glu Met Leu Phe Ile 
        275                 280                 285             


Pro Ser Arg Gln Xaa Val Pro Xaa Tyr Lys Lys Leu Pro Glu Asn Val 
    290                 295                 300                 


Gln Pro Arg Phe Leu Glu Asp Glu Gly Leu Tyr Xaa Gly Val Arg Pro 
305                 310                 315                 320 


Glu Val Ala Arg Xaa Asn Gln Asn Ile Met Glu Asn Arg Leu Leu Met 
                325                 330                 335     


Gln Asp Pro Glu Arg Arg Trp Phe Gly Asp Asp Gly Arg Ile Leu Ala 
            340                 345                 350         


Leu Pro Asn Pro Ile Lys Pro Phe Pro Ser Arg Pro Pro Val Leu Xaa 
        355                 360                 365             


Gln Glu Gln Ser Ile Lys Ala Glu Leu Glu Xaa Leu Tyr Lys Lys Ala 
    370                 375                 380                 


Val Lys Tyr Val His Ser Ser Gln His Val Ile Arg Ser Gly Asp Pro 
385                 390                 395                 400 


Pro Gly Asn Phe Gln Leu Asp Ile Asp Ile Ser Gly Leu Ile Phe Xaa 
                405                 410                 415     


His His Pro Cys Phe Ser Arg Glu His Val Leu Ala Ala Lys Leu Ala 
            420                 425                 430         


Gln Leu Tyr Asp Gln Tyr Leu Ala Arg His Gln Arg Asn Lys Ala Lys 
        435                 440                 445             


Phe Leu Xaa Asp Lys Leu Gln Ala Leu Arg Asn Ala Val Gln Xaa Gly 
    450                 455                 460                 


Leu Asp Pro Glu Lys Pro His Gln Ser Leu Asp Xaa Ile Gln Lys Xaa 
465                 470                 475                 480 


Ile Asn Glu Tyr Lys Ser Glu Ile Arg Gln Xaa Arg Lys Phe Arg Asp 
                485                 490                 495     


Ala Glu Gln Glu Lys Asp Arg Xaa Leu Leu Lys Xaa Ile Ile Lys Val 
            500                 505                 510         


Trp Lys Glu Met Lys Ser Leu Arg Glu Phe Gln Arg Phe Xaa Asn Xaa 
        515                 520                 525             


Pro Leu Lys Leu Val Leu Arg Lys Glu Lys Ala Asp Gln Lys Ala Asp 
    530                 535                 540                 


Glu Glu Ala Tyr Glu Ala Glu Ile Gln Ala Glu Ile Ser Glu Leu Leu 
545                 550                 555                 560 


Glu Glu His Xaa Glu Glu Tyr Ala Gln Lys Met Glu Glu Tyr Arg Xaa 
                565                 570                 575     


Ser Leu Gln Gln Trp Lys Ala Trp Arg Lys Val Gln Arg Ala Lys Lys 
            580                 585                 590         


Lys Lys Arg Lys Gln Ala Ala Glu Glu His Pro Gly Asp Glu Ile Ala 
        595                 600                 605             


Glu Pro Tyr Pro Glu Glu Asp Leu Val Lys Pro Ser Pro Pro Glu Pro 
    610                 615                 620                 


Xaa Asp Arg Ala Val Ile Glu Gln Glu Val Arg Glu Arg Ala Ala Gln 
625                 630                 635                 640 


Ser Arg Arg Arg Pro Trp Glu Pro Xaa Leu Val Pro Glu Leu Ser Leu 
                645                 650                 655     


Ala Gly Ser Val Xaa Pro Asn Asp Gln Cys Pro Arg Ala Glu Val Ser 
            660                 665                 670         


Arg Arg Glu Asp Val Lys Lys Arg Ser Val Tyr Leu Lys Val Leu Phe 
        675                 680                 685             


Asn Asn Lys Glu Val Ser Arg Xaa Val Ser Arg Pro Leu Gly Ala Asp 
    690                 695                 700                 


Phe Arg Val His Phe Gly Gln Ile Phe Asn Leu Gln Ile Val Asn Trp 
705                 710                 715                 720 


Pro Glu Ser Leu Xaa Leu Gln Val Tyr Glu Xaa Val Gly His Ser Ser 
                725                 730                 735     


Pro Xaa Leu Leu Ala Glu Val Phe Leu Pro Ile Pro Glu Xaa Xaa Val 
            740                 745                 750         


Val Xaa Gly Arg Ala Pro Xaa Glu Glu Val Glu Phe Ser Ser Asn Gln 
        755                 760                 765             


His Val Xaa Leu Asp His Glu Gly Val Gly Ser Gly Val Pro Phe Ser 
    770                 775                 780                 


Phe Glu Ala Asp Gly Ser Asn Gln Leu Xaa Leu Met Xaa Ser Gly Lys 
785                 790                 795                 800 


Val Ser His Ser Val Ala Trp Ala Ile Gly Glu Asn Gly Ile Pro Leu 
                805                 810                 815     


Ile Pro Pro Leu Ser Gln Gln Asn Ile Gly Phe Arg Ser Ala Leu Lys 
            820                 825                 830         


Lys Ala Asp Ala Ile Ser Ser Ile Gly Xaa Ser Gly Leu Xaa Asp Met 
        835                 840                 845             


Lys Lys Leu Ala Lys Trp Ala Ala Glu Ser Lys Leu Asp Pro Asn Asp 
    850                 855                 860                 


Pro Asn Asn Ala Pro Leu Met Gln Leu Ile Ser Val Ala Xaa Ser Gly 
865                 870                 875                 880 


Glu Ser Tyr Val Pro Asp Phe Phe Arg Leu Glu Gln Leu Gln Gln Glu 
                885                 890                 895     


Phe Asn Phe Val Ser Asp Gln Glu Leu Asn Arg Ser Lys Arg Phe Arg 
            900                 905                 910         


Leu Leu His Leu Arg Ser Gln Glu Val Pro Glu Phe Arg Asn Tyr Lys 
        915                 920                 925             


Gln Val Pro Val Tyr Asp Arg Glu Ile Met Glu Lys Val Phe Gln Asp 
    930                 935                 940                 


Tyr Glu Lys Arg Leu Arg Asp Arg Asn Val Ile Glu Xaa Lys Glu His 
945                 950                 955                 960 


Ile Asp Xaa His Arg Ala Ile Val Ala Lys Tyr Leu Gln Gln Val Arg 
                965                 970                 975     


Glu Ser Val Ile Asn Arg Phe Leu Ile Ala Lys Gln Tyr Phe Leu Leu 
            980                 985                 990         


Ala Asp Met Ile Val Glu Glu Glu  Val Pro Asn Ile Ser  Ile Leu Gly 
        995                 1000                 1005             


Leu Ser  Leu Phe Lys Leu Ala  Glu Gln Lys Arg Pro  Leu Arg Pro 
    1010                 1015                 1020             


Arg Arg  Lys Gly Arg Lys Lys  Val Xaa Ala Gln Asn  Leu Ser Asp 
    1025                 1030                 1035             


Gly Asp  Ile Lys Leu Leu Val  Asn Ile Val Arg Ala  Tyr Asp Ile 
    1040                 1045                 1050             


Pro Val  Arg Lys Pro Ala Val  Ser Lys Phe Gln Gln  Pro Ser Arg 
    1055                 1060                 1065             


Ser Ser  Arg Met Phe Ser Glu  Lys His Ala Ala Ser  Pro Ser Xaa 
    1070                 1075                 1080             


Tyr Ser  Pro Xaa His Asn Ala  Asp Tyr Pro Leu Gly  Gln Val Leu 
    1085                 1090                 1095             


Val Arg  Pro Phe Val Glu Val  Ser Phe Gln Arg Xaa  Val Cys His 
    1100                 1105                 1110             


Xaa Xaa  Xaa Ala Glu Gly Pro  Asn Pro Ser Trp Asn  Glu Glu Leu 
    1115                 1120                 1125             


Glu Leu  Pro Phe Arg Ala Pro  Asn Gly Asp Tyr Ser  Xaa Ala Ser 
    1130                 1135                 1140             


Leu Gln  Ser Val Lys Asp Val  Val Phe Ile Asn Ile  Phe Asp Glu 
    1145                 1150                 1155             


Val Leu  His Asp Val Leu Glu  Asp Asp Arg Glu Arg  Gly Ser Gly 
    1160                 1165                 1170             


Ile His  Xaa Arg Ile Glu Arg  His Trp Leu Gly Cys  Val Lys Met 
    1175                 1180                 1185             


Pro Phe  Ser Xaa Ile Tyr Phe  Gln Ala Arg Ile Asp  Gly Xaa Phe 
    1190                 1195                 1200             


Lys Ile  Asp Ile Pro Pro Val  Leu Leu Gly Tyr Ser  Lys Glu Arg 
    1205                 1210                 1215             


Asn Met  Ile Leu Glu Arg Gly  Phe Asp Ser Val Arg  Ser Leu Ser 
    1220                 1225                 1230             


Glu Gly  Ser Tyr Ile Xaa Leu  Phe Ile Xaa Ile Glu  Pro Gln Leu 
    1235                 1240                 1245             


Val Pro  Gly Glu Ser Ile Arg  Glu Lys Phe Glu Ser  Gln Glu Asp 
    1250                 1255                 1260             


Glu Lys  Leu Leu Gln Ala Xaa  Glu Lys Phe Gln Ala  Glu Cys Ala 
    1265                 1270                 1275             


Leu Lys  Phe Pro Asn Arg Gln  Cys Leu Xaa Xaa Val  Ile Asp Ile 
    1280                 1285                 1290             


Ser Gly  Lys Xaa Val Phe Ile  Xaa Arg Tyr Leu Lys  Pro Leu Asn 
    1295                 1300                 1305             


Pro Pro  Gln Glu Leu Leu Asn  Val Tyr Pro Asn Asn  Leu Gln Ala 
    1310                 1315                 1320             


Xaa Ala  Glu Leu Val Ala Arg  Tyr Val Ser Leu Ile  Pro Phe Leu 
    1325                 1330                 1335             


Pro Asp  Xaa Val Ser Phe Gly  Gly Ile Cys Asp Leu  Trp Ser Xaa 
    1340                 1345                 1350             


Ser Asp  Gln Phe Leu Asp Leu  Leu Ala Gly Asp Glu  Glu Glu His 
    1355                 1360                 1365             


Ala Val  Leu Leu Cys Asn Tyr  Phe Leu Ser Leu Gly  Lys Lys Ala 
    1370                 1375                 1380             


Trp Leu  Leu Met Gly Asn Ala  Ile Pro Glu Gly Pro  Xaa Ala Tyr 
    1385                 1390                 1395             


Val Leu  Xaa Trp Glu Gln Gly  Arg Tyr Leu Ile Trp  Asn Pro Cys 
    1400                 1405                 1410             


Ser Gly  His Phe Tyr Gly Gln  Phe Asp Xaa Phe Cys  Pro Leu Lys 
    1415                 1420                 1425             


Asn Val  Gly Cys Leu Ile Gly  Pro Asp Asn Ile Trp  Phe Asn Ile 
    1430                 1435                 1440             


Gln Arg  Tyr Glu Ser Pro Leu  Arg Ile Asn Phe Asp  Val Xaa Arg 
    1445                 1450                 1455             


Pro Lys  Leu Trp Lys Ser Phe  Phe Ser Arg Ser Leu  Pro Tyr Pro 
    1460                 1465                 1470             


Gly Leu  Ser Ser Val Gln Pro  Glu Glu Leu Ile Tyr  Gln Arg Ser 
    1475                 1480                 1485             


Asp Lys  Ala Ala Ala Ala Glu  Leu Gln Asp Arg Ile  Glu Lys Ile 
    1490                 1495                 1500             


Leu Lys  Glu Lys Ile Met Asp  Trp Arg Pro Arg His  Leu Xaa Arg 
    1505                 1510                 1515             


Trp Asn  Arg Tyr Cys Xaa Ser  Xaa Leu Arg His Phe  Leu Pro Leu 
    1520                 1525                 1530             


Leu Glu  Lys Ser Gln Gly Glu  Asp Val Glu Asp Asp  His Arg Ala 
    1535                 1540                 1545             


Glu Leu  Leu Lys Gln Leu Gly  Asp Tyr Arg Phe Ser  Gly Phe Pro 
    1550                 1555                 1560             


Leu His  Met Pro Tyr Ser Glu  Val Lys Pro Leu Ile  Asp Ala Val 
    1565                 1570                 1575             


Tyr Ser  Xaa Gly Val His Asn  Ile Asp Val Pro Asn  Val Glu Phe 
    1580                 1585                 1590             


Ala Leu  Ala Val Tyr Ile His  Pro Tyr Pro Lys Asn  Val Leu Ser 
    1595                 1600                 1605             


Val Trp  Ile Tyr Val Ala Ser  Leu Ile Arg Asn Arg  
    1610                 1615                 1620 


<210> 5183
<211> 142
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<400> 5183
Xaa Asp Xaa Phe Cys Pro Leu Lys Asn Val Gly Cys Leu Ile Gly Pro 
1               5                   10                  15      


Asp Asn Pro Glu Glu Leu Ile Tyr Gln Arg Ser Asp Lys Ala Ala Ala 
            20                  25                  30          


Ala Glu Leu Gln Asp Arg Ile Glu Lys Ile Leu Lys Glu Lys Ile Met 
        35                  40                  45              


Asp Trp Arg Pro Arg His Leu Xaa Arg Trp Asn Arg Tyr Cys Xaa Ser 
    50                  55                  60                  


Xaa Leu Arg His Phe Leu Pro Leu Leu Glu Lys Ser Gln Gly Glu Asp 
65                  70                  75                  80  


Val Glu Asp Asp His Arg Ala Glu Leu Leu Lys Gln Leu Gly Asp Tyr 
                85                  90                  95      


Arg Phe Ser Gly Phe Pro Leu His Met Pro Tyr Ser Glu Val Lys Pro 
            100                 105                 110         


Leu Ile Asp Ala Val Tyr Ser Xaa Gly Val His Asn Ile Asp Val Pro 
        115                 120                 125             


Asn Val Glu Phe Ala Leu Ala Val Tyr Ile His Pro Tyr Pro 
    130                 135                 140         


<210> 5184
<211> 903
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<400> 5184
Xaa Leu Leu Glu Glu His Xaa Glu Glu Tyr Ala Gln Lys Met Glu Glu 
1               5                   10                  15      


Tyr Arg Xaa Ser Leu Gln Gln Trp Lys Ala Trp Arg Lys Val Gln Arg 
            20                  25                  30          


Ala Lys Lys Lys Lys Arg Lys Gln Ala Ala Glu Glu His Pro Gly Asp 
        35                  40                  45              


Glu Ile Ala Glu Pro Tyr Pro Glu Glu Asp Leu Val Lys Pro Ser Pro 
    50                  55                  60                  


Pro Glu Pro Xaa Asp Arg Ala Val Ile Glu Gln Glu Val Arg Glu Arg 
65                  70                  75                  80  


Ala Ala Gln Ser Arg Arg Arg Pro Trp Glu Pro Xaa Leu Val Pro Glu 
                85                  90                  95      


Leu Ser Leu Ala Gly Ser Val Xaa Pro Asn Asp Gln Cys Pro Arg Ala 
            100                 105                 110         


Glu Val Ser Arg Arg Glu Asp Val Lys Lys Arg Ser Val Tyr Leu Lys 
        115                 120                 125             


Val Leu Phe Asn Asn Lys Glu Val Ser Arg Xaa Val Ser Arg Pro Leu 
    130                 135                 140                 


Gly Ala Asp Phe Arg Val His Phe Gly Gln Ile Phe Asn Leu Gln Ile 
145                 150                 155                 160 


Val Asn Trp Pro Glu Ser Leu Xaa Leu Gln Val Tyr Glu Xaa Val Gly 
                165                 170                 175     


His Ser Ser Pro Xaa Leu Leu Ala Glu Val Phe Leu Pro Ile Pro Glu 
            180                 185                 190         


Xaa Xaa Val Val Xaa Gly Arg Ala Pro Xaa Glu Glu Val Glu Phe Ser 
        195                 200                 205             


Ser Asn Gln His Val Xaa Leu Asp His Glu Gly Val Gly Ser Gly Val 
    210                 215                 220                 


Pro Phe Ser Phe Glu Ala Asp Gly Ser Asn Gln Leu Xaa Leu Met Xaa 
225                 230                 235                 240 


Ser Gly Lys Val Ser His Ser Val Ala Trp Ala Ile Gly Glu Asn Gly 
                245                 250                 255     


Ile Pro Leu Ile Pro Pro Leu Ser Gln Gln Asn Ile Gly Phe Arg Ser 
            260                 265                 270         


Ala Leu Lys Lys Ala Asp Ala Ile Ser Ser Ile Gly Xaa Ser Gly Leu 
        275                 280                 285             


Xaa Asp Met Lys Lys Leu Ala Lys Trp Ala Ala Glu Ser Lys Leu Asp 
    290                 295                 300                 


Pro Asn Asp Pro Asn Asn Ala Pro Leu Met Gln Leu Ile Ser Val Ala 
305                 310                 315                 320 


Xaa Ser Gly Glu Ser Tyr Val Pro Asp Phe Phe Arg Leu Glu Gln Leu 
                325                 330                 335     


Gln Gln Glu Phe Asn Phe Val Ser Asp Gln Glu Leu Asn Arg Ser Lys 
            340                 345                 350         


Arg Phe Arg Leu Leu His Leu Arg Ser Gln Glu Val Pro Glu Phe Arg 
        355                 360                 365             


Asn Tyr Lys Gln Val Pro Val Tyr Asp Arg Glu Ile Met Glu Lys Val 
    370                 375                 380                 


Phe Gln Asp Tyr Glu Lys Arg Leu Arg Asp Arg Asn Val Ile Glu Xaa 
385                 390                 395                 400 


Lys Glu His Ile Asp Xaa His Arg Ala Ile Val Ala Lys Tyr Leu Gln 
                405                 410                 415     


Gln Val Arg Glu Ser Val Ile Asn Arg Phe Leu Ile Ala Lys Gln Tyr 
            420                 425                 430         


Phe Leu Leu Ala Asp Met Ile Val Glu Glu Glu Val Pro Asn Ile Ser 
        435                 440                 445             


Ile Leu Gly Leu Ser Leu Phe Lys Leu Ala Glu Gln Lys Arg Pro Leu 
    450                 455                 460                 


Arg Pro Arg Arg Lys Gly Arg Lys Lys Val Xaa Ala Gln Asn Leu Ser 
465                 470                 475                 480 


Asp Gly Asp Ile Lys Leu Leu Val Asn Ile Val Arg Ala Tyr Asp Ile 
                485                 490                 495     


Pro Val Arg Lys Pro Ala Val Ser Lys Phe Gln Gln Pro Ser Arg Ser 
            500                 505                 510         


Ser Arg Met Phe Ser Glu Lys His Ala Ala Ser Pro Ser Xaa Tyr Ser 
        515                 520                 525             


Pro Xaa His Asn Ala Asp Tyr Pro Leu Gly Gln Val Leu Val Arg Pro 
    530                 535                 540                 


Phe Val Glu Val Ser Phe Gln Arg Xaa Val Cys His Xaa Xaa Xaa Ala 
545                 550                 555                 560 


Glu Gly Pro Asn Pro Ser Trp Asn Glu Glu Leu Glu Leu Pro Phe Arg 
                565                 570                 575     


Ala Pro Asn Gly Asp Tyr Ser Xaa Ala Ser Leu Gln Ser Val Lys Asp 
            580                 585                 590         


Val Val Phe Ile Asn Ile Phe Asp Glu Val Leu His Asp Val Leu Glu 
        595                 600                 605             


Asp Asp Arg Glu Arg Gly Ser Gly Ile His Xaa Arg Ile Glu Arg His 
    610                 615                 620                 


Trp Leu Gly Cys Val Lys Met Pro Phe Ser Xaa Ile Tyr Phe Gln Ala 
625                 630                 635                 640 


Arg Ile Asp Gly Xaa Phe Lys Ile Asp Ile Pro Pro Val Leu Leu Gly 
                645                 650                 655     


Tyr Ser Lys Glu Arg Asn Met Ile Leu Glu Arg Gly Phe Asp Ser Val 
            660                 665                 670         


Arg Ser Leu Ser Glu Gly Ser Tyr Ile Xaa Leu Phe Ile Xaa Ile Glu 
        675                 680                 685             


Pro Gln Leu Val Pro Gly Glu Ser Ile Arg Glu Lys Phe Glu Ser Gln 
    690                 695                 700                 


Glu Asp Glu Lys Leu Leu Gln Ala Xaa Glu Lys Phe Gln Ala Glu Cys 
705                 710                 715                 720 


Ala Leu Lys Phe Pro Asn Arg Gln Cys Leu Xaa Xaa Val Ile Asp Ile 
                725                 730                 735     


Ser Gly Lys Xaa Val Phe Ile Xaa Arg Tyr Leu Lys Pro Leu Asn Pro 
            740                 745                 750         


Pro Gln Glu Leu Leu Asn Val Tyr Pro Asn Asn Leu Gln Ala Xaa Ala 
        755                 760                 765             


Glu Leu Val Ala Arg Tyr Val Ser Leu Ile Pro Phe Leu Pro Asp Xaa 
    770                 775                 780                 


Val Ser Phe Gly Gly Ile Cys Asp Leu Trp Ser Xaa Ser Asp Gln Phe 
785                 790                 795                 800 


Leu Asp Leu Leu Ala Gly Asp Glu Glu Glu His Ala Val Leu Leu Cys 
                805                 810                 815     


Asn Tyr Phe Leu Ser Leu Gly Lys Lys Ala Trp Leu Leu Met Gly Asn 
            820                 825                 830         


Ala Ile Pro Glu Gly Pro Xaa Ala Tyr Val Leu Xaa Trp Glu Gln Gly 
        835                 840                 845             


Arg Tyr Leu Ile Trp Asn Pro Cys Ser Gly His Phe Tyr Gly Gln Phe 
    850                 855                 860                 


Asp Xaa Phe Cys Pro Leu Lys Asn Val Gly Cys Leu Ile Gly Pro Asp 
865                 870                 875                 880 


Asn Ala Gln Ala Met Glu Ile Phe Leu Phe Lys Lys Pro Ser Ile Ser 
                885                 890                 895     


Trp Pro Phe Gln Cys Ser Ala 
            900             


<210> 5185
<211> 1453
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1103)..(1103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1234)..(1234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1357)..(1357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1359)..(1359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<400> 5185
Xaa Val Pro Pro Gly Phe Pro Ser Ala Glu Glu Ala Tyr Asn Phe Phe 
1               5                   10                  15      


Xaa Phe Asn Phe Asp Pro Glu Pro Glu Gly Ser Glu Glu Lys Pro Lys 
            20                  25                  30          


Ala Arg His Arg Ala Gly Xaa Asn Gln Glu Glu Glu Glu Gly Glu Glu 
        35                  40                  45              


Glu Glu Pro Pro Ala Gln Gly Gly Gly Lys Glu Met Asp Glu Glu Glu 
    50                  55                  60                  


Leu Leu Asn Gly Asp Asp Ala Glu Asp Phe Leu Leu Gly Leu Asp His 
65                  70                  75                  80  


Val Ala Asp Asp Phe Val Ala Val Arg Pro Ala Asp Tyr Glu Ser Ile 
                85                  90                  95      


His Asp Arg Leu Gln Met Glu Arg Glu Met Leu Phe Ile Pro Ser Arg 
            100                 105                 110         


Gln Xaa Val Pro Xaa Tyr Lys Lys Leu Pro Glu Asn Val Gln Pro Arg 
        115                 120                 125             


Phe Leu Glu Asp Glu Gly Leu Tyr Xaa Gly Val Arg Pro Glu Val Ala 
    130                 135                 140                 


Arg Xaa Asn Gln Asn Ile Met Glu Asn Arg Leu Leu Met Gln Asp Pro 
145                 150                 155                 160 


Glu Arg Arg Trp Phe Gly Asp Asp Gly Arg Ile Leu Ala Leu Pro Asn 
                165                 170                 175     


Pro Ile Lys Pro Phe Pro Ser Arg Pro Pro Val Leu Xaa Gln Glu Gln 
            180                 185                 190         


Ser Ile Lys Ala Glu Leu Glu Xaa Leu Tyr Lys Lys Ala Val Lys Tyr 
        195                 200                 205             


Val His Ser Ser Gln His Val Ile Arg Ser Gly Asp Pro Pro Gly Asn 
    210                 215                 220                 


Phe Gln Leu Asp Ile Asp Ile Ser Gly Leu Ile Phe Xaa His His Pro 
225                 230                 235                 240 


Cys Phe Ser Arg Glu His Val Leu Ala Ala Lys Leu Ala Gln Leu Tyr 
                245                 250                 255     


Asp Gln Tyr Leu Ala Arg His Gln Arg Asn Lys Ala Lys Phe Leu Xaa 
            260                 265                 270         


Asp Lys Leu Gln Ala Leu Arg Asn Ala Val Gln Xaa Gly Leu Asp Pro 
        275                 280                 285             


Glu Lys Pro His Gln Ser Leu Asp Xaa Ile Gln Lys Xaa Ile Asn Glu 
    290                 295                 300                 


Tyr Lys Ser Glu Ile Arg Gln Xaa Arg Lys Phe Arg Asp Ala Glu Gln 
305                 310                 315                 320 


Glu Lys Asp Arg Xaa Leu Leu Lys Xaa Ile Ile Lys Val Trp Lys Glu 
                325                 330                 335     


Met Lys Ser Leu Arg Glu Phe Gln Arg Phe Xaa Asn Xaa Pro Leu Lys 
            340                 345                 350         


Leu Val Leu Arg Lys Glu Lys Ala Asp Gln Lys Ala Asp Glu Glu Ala 
        355                 360                 365             


Tyr Glu Ala Glu Ile Gln Ala Glu Ile Ser Glu Leu Leu Glu Glu His 
    370                 375                 380                 


Xaa Glu Glu Tyr Ala Gln Lys Met Glu Glu Tyr Arg Xaa Ser Leu Gln 
385                 390                 395                 400 


Gln Trp Lys Ala Trp Arg Lys Val Gln Arg Ala Lys Lys Lys Lys Arg 
                405                 410                 415     


Lys Gln Ala Ala Glu Glu His Pro Gly Asp Glu Ile Ala Glu Pro Tyr 
            420                 425                 430         


Pro Glu Glu Asp Leu Val Lys Pro Ser Pro Pro Glu Pro Xaa Asp Arg 
        435                 440                 445             


Ala Val Ile Glu Gln Glu Val Arg Glu Arg Ala Ala Gln Ser Arg Arg 
    450                 455                 460                 


Arg Pro Trp Glu Pro Xaa Leu Val Pro Glu Leu Ser Leu Ala Gly Ser 
465                 470                 475                 480 


Val Xaa Pro Asn Asp Gln Cys Pro Arg Ala Glu Val Ser Arg Arg Glu 
                485                 490                 495     


Asp Val Lys Lys Arg Ser Val Tyr Leu Lys Val Leu Phe Asn Asn Lys 
            500                 505                 510         


Glu Val Ser Arg Xaa Val Ser Arg Pro Leu Gly Ala Asp Phe Arg Val 
        515                 520                 525             


His Phe Gly Gln Ile Phe Asn Leu Gln Ile Val Asn Trp Pro Glu Ser 
    530                 535                 540                 


Leu Xaa Leu Gln Val Tyr Glu Xaa Val Gly His Ser Ser Pro Xaa Leu 
545                 550                 555                 560 


Leu Ala Glu Val Phe Leu Pro Ile Pro Glu Xaa Xaa Val Val Xaa Gly 
                565                 570                 575     


Arg Ala Pro Xaa Glu Glu Val Glu Phe Ser Ser Asn Gln His Val Xaa 
            580                 585                 590         


Leu Asp His Glu Gly Val Gly Ser Gly Val Pro Phe Ser Phe Glu Ala 
        595                 600                 605             


Asp Gly Ser Asn Gln Leu Xaa Leu Met Xaa Ser Gly Lys Val Ser His 
    610                 615                 620                 


Ser Val Ala Trp Ala Ile Gly Glu Asn Gly Ile Pro Leu Ile Pro Pro 
625                 630                 635                 640 


Leu Ser Gln Gln Asn Ile Gly Phe Arg Ser Ala Leu Lys Lys Ala Asp 
                645                 650                 655     


Ala Ile Ser Ser Ile Gly Xaa Ser Gly Leu Xaa Asp Met Lys Lys Leu 
            660                 665                 670         


Ala Lys Trp Ala Ala Glu Ser Lys Leu Asp Pro Asn Asp Pro Asn Asn 
        675                 680                 685             


Ala Pro Leu Met Gln Leu Ile Ser Val Ala Xaa Ser Gly Glu Ser Tyr 
    690                 695                 700                 


Val Pro Asp Phe Phe Arg Leu Glu Gln Leu Gln Gln Glu Phe Asn Phe 
705                 710                 715                 720 


Val Ser Asp Gln Glu Leu Asn Arg Ser Lys Arg Phe Arg Leu Leu His 
                725                 730                 735     


Leu Arg Ser Gln Glu Val Pro Glu Phe Arg Asn Tyr Lys Gln Val Pro 
            740                 745                 750         


Val Tyr Asp Arg Glu Ile Met Glu Lys Val Phe Gln Asp Tyr Glu Lys 
        755                 760                 765             


Arg Leu Arg Asp Arg Asn Val Ile Glu Xaa Lys Glu His Ile Asp Xaa 
    770                 775                 780                 


His Arg Ala Ile Val Ala Lys Tyr Leu Gln Gln Val Arg Glu Ser Val 
785                 790                 795                 800 


Ile Asn Arg Phe Leu Ile Ala Lys Gln Tyr Phe Leu Leu Ala Asp Met 
                805                 810                 815     


Ile Val Glu Glu Glu Val Pro Asn Ile Ser Ser Glu Gly Ser Gly Ile 
            820                 825                 830         


Leu Gly Leu Ser Leu Phe Lys Leu Ala Glu Gln Lys Arg Pro Leu Arg 
        835                 840                 845             


Pro Arg Arg Lys Gly Arg Lys Lys Val Xaa Ala Gln Asn Leu Ser Asp 
    850                 855                 860                 


Gly Asp Ile Lys Leu Leu Val Asn Ile Val Arg Ala Tyr Asp Ile Pro 
865                 870                 875                 880 


Val Arg Lys Pro Ala Val Ser Lys Phe Gln Gln Pro Ser Arg Ser Ser 
                885                 890                 895     


Arg Met Phe Ser Glu Lys His Ala Ala Ser Pro Ser Xaa Tyr Ser Pro 
            900                 905                 910         


Xaa His Asn Ala Asp Tyr Pro Leu Gly Gln Val Leu Val Arg Pro Phe 
        915                 920                 925             


Val Glu Val Ser Phe Gln Arg Xaa Val Cys His Xaa Xaa Xaa Ala Glu 
    930                 935                 940                 


Gly Pro Asn Pro Ser Trp Asn Glu Glu Leu Glu Leu Pro Phe Arg Ala 
945                 950                 955                 960 


Pro Asn Gly Asp Tyr Ser Xaa Ala Ser Leu Gln Ser Val Lys Asp Val 
                965                 970                 975     


Val Phe Ile Asn Ile Phe Asp Glu Val Leu His Asp Val Leu Glu Asp 
            980                 985                 990         


Asp Arg Glu Arg Gly Ser Gly Ile  His Xaa Arg Ile Glu  Arg His Trp 
        995                 1000                 1005             


Leu Gly  Cys Val Lys Met Pro  Phe Ser Xaa Ile Tyr  Phe Gln Ala 
    1010                 1015                 1020             


Arg Ile  Asp Gly Xaa Phe Lys  Ile Asp Ile Pro Pro  Val Leu Leu 
    1025                 1030                 1035             


Gly Tyr  Ser Lys Glu Arg Asn  Met Ile Leu Glu Arg  Gly Phe Asp 
    1040                 1045                 1050             


Ser Val  Arg Ser Leu Ser Glu  Gly Ser Tyr Ile Xaa  Leu Phe Ile 
    1055                 1060                 1065             


Xaa Ile  Glu Pro Gln Leu Val  Pro Gly Glu Ser Ile  Arg Glu Lys 
    1070                 1075                 1080             


Met Ser  Asn Met Leu Lys Lys  Phe Glu Ser Gln Glu  Asp Glu Lys 
    1085                 1090                 1095             


Leu Leu  Gln Ala Xaa Glu Lys  Phe Gln Ala Glu Cys  Ala Leu Lys 
    1100                 1105                 1110             


Phe Pro  Asn Arg Gln Cys Leu  Xaa Xaa Val Ile Asp  Ile Ser Gly 
    1115                 1120                 1125             


Lys Xaa  Val Phe Ile Xaa Arg  Tyr Leu Lys Pro Leu  Asn Pro Pro 
    1130                 1135                 1140             


Gln Glu  Leu Leu Asn Val Tyr  Pro Asn Asn Leu Gln  Ala Xaa Ala 
    1145                 1150                 1155             


Glu Leu  Val Ala Arg Tyr Val  Ser Leu Ile Pro Phe  Leu Pro Asp 
    1160                 1165                 1170             


Xaa Val  Ser Phe Gly Gly Ile  Cys Asp Leu Trp Ser  Xaa Ser Asp 
    1175                 1180                 1185             


Gln Phe  Leu Asp Leu Leu Ala  Gly Asp Glu Glu Glu  His Ala Val 
    1190                 1195                 1200             


Leu Leu  Cys Asn Tyr Phe Leu  Ser Leu Gly Lys Lys  Ala Trp Leu 
    1205                 1210                 1215             


Leu Met  Gly Asn Ala Ile Pro  Glu Gly Pro Xaa Ala  Tyr Val Leu 
    1220                 1225                 1230             


Xaa Trp  Glu Gln Gly Arg Tyr  Leu Ile Trp Asn Pro  Cys Ser Gly 
    1235                 1240                 1245             


His Phe  Tyr Gly Gln Phe Asp  Xaa Phe Cys Pro Leu  Lys Asn Val 
    1250                 1255                 1260             


Gly Cys  Leu Ile Gly Pro Asp  Asn Ile Trp Phe Asn  Ile Gln Arg 
    1265                 1270                 1275             


Tyr Glu  Ser Pro Leu Arg Ile  Asn Phe Asp Val Xaa  Arg Pro Lys 
    1280                 1285                 1290             


Leu Trp  Lys Ser Phe Phe Ser  Arg Ser Leu Pro Tyr  Pro Gly Leu 
    1295                 1300                 1305             


Ser Ser  Val Gln Pro Glu Glu  Leu Ile Tyr Gln Arg  Ser Asp Lys 
    1310                 1315                 1320             


Ala Ala  Ala Ala Glu Leu Gln  Asp Arg Ile Glu Lys  Ile Leu Lys 
    1325                 1330                 1335             


Glu Lys  Ile Met Asp Trp Arg  Pro Arg His Leu Xaa  Arg Trp Asn 
    1340                 1345                 1350             


Arg Tyr  Cys Xaa Ser Xaa Leu  Arg His Phe Leu Pro  Leu Leu Glu 
    1355                 1360                 1365             


Lys Ser  Gln Gly Glu Asp Val  Glu Asp Asp His Arg  Ala Glu Leu 
    1370                 1375                 1380             


Leu Lys  Gln Leu Gly Asp Tyr  Arg Phe Ser Gly Phe  Pro Leu His 
    1385                 1390                 1395             


Met Pro  Tyr Ser Glu Val Lys  Pro Leu Ile Asp Ala  Val Tyr Ser 
    1400                 1405                 1410             


Xaa Gly  Val His Asn Ile Asp  Val Pro Asn Val Glu  Phe Ala Leu 
    1415                 1420                 1425             


Ala Val  Tyr Ile His Pro Tyr  Pro Lys Asn Val Leu  Ser Val Trp 
    1430                 1435                 1440             


Ile Tyr  Val Ala Ser Leu Ile  Arg Asn Arg 
    1445                 1450             


<210> 5186
<211> 598
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<400> 5186
Met Leu Phe Val Asp Asp Met Ala Glu Pro Arg Glu Xaa Pro Glu His 
1               5                   10                  15      


Pro Leu Lys Gln Ile Lys Phe Leu Leu Gly Arg Lys Glu Glu Glu Ala 
            20                  25                  30          


Val Leu Val Gly Gly Glu Trp Ser Pro Ser Leu Asp Gly Leu Asp Pro 
        35                  40                  45              


Gln Ala Asp Pro Gln Val Leu Val Arg Xaa Ala Ile Arg Cys Ala Gln 
    50                  55                  60                  


Ala Gln Xaa Gly Ile Asp Leu Ser Gly Cys Xaa Lys Trp Trp Arg Phe 
65                  70                  75                  80  


Ala Glu Phe Gln Tyr Leu Gln Pro Gly Pro Pro Arg Arg Leu Gln Xaa 
                85                  90                  95      


Val Val Val Tyr Leu Pro Asp Val Trp Xaa Ile Met Pro Xaa Leu Glu 
            100                 105                 110         


Glu Trp Glu Ala Leu Cys Gln Gln Lys Ala Ala Glu Ala Ala Pro Pro 
        115                 120                 125             


Xaa Gln Glu Ala Gln Gly Glu Xaa Glu Pro Xaa Glu Gln Ala Pro Asp 
    130                 135                 140                 


Ala Leu Glu Gln Ala Ala Asp Xaa Ser Arg Arg Asn Ala Glu Xaa Pro 
145                 150                 155                 160 


Glu Ala Xaa Xaa Gln Gln Glu Xaa Asp Xaa Asp Leu Pro Glu Ala Pro 
                165                 170                 175     


Pro Pro Pro Leu Glu Pro Ala Val Ile Ala Arg Pro Gly Cys Val Asn 
            180                 185                 190         


Leu Ser Leu His Gly Ile Val Glu Asp Arg Arg Pro Lys Glu Arg Ile 
        195                 200                 205             


Ser Phe Glu Val Met Val Leu Ala Glu Leu Phe Leu Glu Met Leu Gln 
    210                 215                 220                 


Arg Asp Phe Gly Tyr Arg Val Tyr Lys Met Leu Leu Ser Leu Pro Glu 
225                 230                 235                 240 


Lys Val Val Ser Pro Pro Glu Pro Glu Lys Glu Glu Ala Ala Lys Glu 
                245                 250                 255     


Glu Ala Xaa Lys Glu Glu Glu Ala Ile Lys Glu Glu Val Val Lys Glu 
            260                 265                 270         


Pro Lys Asp Glu Ala Gln Asn Glu Gly Pro Ala Xaa Glu Ser Glu Ala 
        275                 280                 285             


Pro Leu Lys Glu Asp Gly Leu Leu Pro Lys Pro Leu Ser Ser Gly Gly 
    290                 295                 300                 


Glu Glu Glu Glu Lys Pro Arg Gly Glu Ala Ser Glu Asp Leu Cys Glu 
305                 310                 315                 320 


Met Ala Leu Asp Pro Glu Leu Leu Leu Leu Arg Asp Asp Gly Glu Glu 
                325                 330                 335     


Glu Phe Ala Gly Ala Lys Leu Glu Asp Ser Glu Val Arg Ser Val Ala 
            340                 345                 350         


Ser Asn Gln Ser Glu Met Glu Phe Ser Ser Leu Gln Asp Met Pro Lys 
        355                 360                 365             


Glu Leu Asp Pro Ser Ala Val Leu Pro Leu Asp Cys Leu Leu Ala Phe 
    370                 375                 380                 


Val Phe Phe Asp Ala Asn Trp Cys Gly Tyr Leu His Arg Arg Asp Leu 
385                 390                 395                 400 


Glu Arg Ile Leu Leu Xaa Leu Gly Ile Arg Leu Ser Ala Glu Gln Ala 
                405                 410                 415     


Lys Gln Leu Val Ser Arg Val Val Xaa Gln Asn Ile Cys Gln Tyr Arg 
            420                 425                 430         


Ser Leu Gln Tyr Ser Arg Gln Glu Gly Leu Asp Gly Gly Leu Pro Glu 
        435                 440                 445             


Glu Val Leu Phe Gly Asn Leu Asp Leu Leu Pro Pro Pro Gly Lys Ser 
    450                 455                 460                 


Xaa Lys Pro Gly Ala Ala Pro Xaa Glu His Lys Ala Leu Val Ser His 
465                 470                 475                 480 


Asn Gly Ser Leu Ile Asn Val Gly Ser Leu Leu Gln Arg Ala Glu Gln 
                485                 490                 495     


Gln Asp Ser Gly Arg Leu Tyr Leu Glu Asn Lys Ile His Xaa Leu Glu 
            500                 505                 510         


Leu Lys Leu Glu Glu Ser His Asn Arg Phe Ser Ala Xaa Glu Val Xaa 
        515                 520                 525             


Asn Lys Xaa Leu Ala Ala Glu Met Gln Glu Leu Arg Val Arg Leu Ala 
    530                 535                 540                 


Glu Ala Glu Glu Xaa Ala Arg Xaa Ala Glu Arg Gln Lys Ser Gln Leu 
545                 550                 555                 560 


Gln Arg Leu Leu Gln Glu Leu Arg Arg Arg Leu Xaa Pro Leu Gln Leu 
                565                 570                 575     


Glu Ile Gln Arg Val Val Glu Lys Val Arg Trp Gly Trp Xaa Arg Arg 
            580                 585                 590         


Gln His Ser Ser Phe Pro 
        595             


<210> 5187
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<400> 5187
Met Ser Gln Phe Lys Arg Gln Arg Ile Asn Pro Leu Pro Gly Gly Arg 
1               5                   10                  15      


Asn Phe Ser Gly Xaa Ala Ser Xaa Ser Leu Leu Gly Pro Pro Pro Gly 
            20                  25                  30          


Leu Leu Xaa Pro Pro Val Ala Xaa Glu Leu Ser Gln Asn Ala Arg His 
        35                  40                  45              


Leu Gln Gly Gly Glu Lys Gln Arg Val Phe Xaa Gly Ile Val Xaa Ser 
    50                  55                  60                  


Leu His Asp Tyr Phe Gly Val Val Asp Glu Glu Val Phe Phe Gln Leu 
65                  70                  75                  80  


Arg 
    


<210> 5188
<211> 150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 5188
Met Ser Gln Phe Lys Arg Gln Arg Ile Asn Pro Leu Pro Gly Gly Arg 
1               5                   10                  15      


Asn Phe Ser Gly Xaa Ala Ser Xaa Ser Leu Leu Gly Pro Pro Pro Gly 
            20                  25                  30          


Leu Leu Xaa Pro Pro Val Ala Xaa Glu Leu Ser Gln Asn Ala Arg His 
        35                  40                  45              


Leu Gln Gly Gly Glu Lys Gln Arg Val Phe Xaa Gly Ile Val Xaa Ser 
    50                  55                  60                  


Leu His Asp Tyr Phe Gly Val Val Asp Glu Glu Val Phe Phe Gln Leu 
65                  70                  75                  80  


Ser Val Val Lys Gly Arg Leu Pro Gln Leu Gly Glu Lys Val Leu Val 
                85                  90                  95      


Lys Ala Ala Tyr Asn Pro Gly Gln Ala Val Pro Trp Asn Ala Val Lys 
            100                 105                 110         


Val Gln Xaa Leu Ser Asn Gln Pro Leu Leu Lys Ser Pro Ala Pro Pro 
        115                 120                 125             


Leu Leu His Val Ala Ala Leu Gly Gln Lys Gln Gly Ile Leu Gly Ala 
    130                 135                 140                 


Gln Pro Gln Leu Ile Phe 
145                 150 


<210> 5189
<211> 162
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 5189
Met Ser Gln Phe Lys Arg Gln Arg Ile Asn Pro Leu Pro Gly Gly Arg 
1               5                   10                  15      


Asn Phe Ser Gly Xaa Ala Ser Xaa Ser Leu Leu Gly Pro Pro Pro Gly 
            20                  25                  30          


Leu Leu Xaa Pro Pro Val Ala Xaa Glu Leu Ser Gln Asn Ala Arg His 
        35                  40                  45              


Leu Gln Gly Gly Glu Lys Gln Arg Val Phe Xaa Gly Ile Val Xaa Ser 
    50                  55                  60                  


Leu His Asp Tyr Phe Gly Val Val Asp Glu Glu Val Phe Phe Gln Leu 
65                  70                  75                  80  


Ser Val Val Lys Gly Arg Leu Pro Gln Leu Gly Glu Lys Val Leu Val 
                85                  90                  95      


Lys Ala Ala Tyr Asn Pro Gly Gln Ala Val Pro Trp Asn Ala Val Lys 
            100                 105                 110         


Val Gln Xaa Leu Ser Asn Gln Pro Leu Leu Lys Ser Pro Ala Pro Pro 
        115                 120                 125             


Leu Leu His Val Ala Ala Leu Gly Gln Lys Gln Gly Ile Leu Gly Ala 
    130                 135                 140                 


Gln Pro Gln Leu Ile Phe Gln Pro His Arg Ile Pro Pro Leu Phe Pro 
145                 150                 155                 160 


Gln Lys 
        


<210> 5190
<211> 923
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<400> 5190
Met Ser Gln Phe Lys Arg Gln Arg Ile Asn Pro Leu Pro Gly Gly Arg 
1               5                   10                  15      


Asn Phe Ser Gly Xaa Ala Ser Xaa Ser Leu Leu Gly Pro Pro Pro Gly 
            20                  25                  30          


Leu Leu Xaa Pro Pro Val Ala Xaa Glu Leu Ser Gln Asn Ala Arg His 
        35                  40                  45              


Leu Gln Gly Gly Glu Lys Gln Arg Val Phe Xaa Gly Ile Val Xaa Ser 
    50                  55                  60                  


Leu His Asp Tyr Phe Gly Val Val Asp Glu Glu Val Phe Phe Gln Leu 
65                  70                  75                  80  


Ser Val Val Lys Gly Arg Leu Pro Gln Leu Gly Glu Lys Val Leu Val 
                85                  90                  95      


Lys Ala Ala Tyr Asn Pro Gly Gln Ala Val Pro Trp Asn Ala Val Lys 
            100                 105                 110         


Val Gln Xaa Leu Ser Asn Gln Pro Leu Leu Lys Ser Pro Ala Pro Pro 
        115                 120                 125             


Leu Leu His Val Ala Ala Leu Gly Gln Lys Gln Gly Ile Leu Gly Ala 
    130                 135                 140                 


Gln Pro Gln Leu Ile Phe Gln Pro His Arg Ile Pro Pro Leu Phe Pro 
145                 150                 155                 160 


Gln Lys Pro Leu Ser Leu Phe Gln Xaa Ser His Xaa Leu His Leu Ser 
                165                 170                 175     


His Leu Asn Arg Phe Pro Ala Arg Gly Pro His Gly Arg Leu Asp Gln 
            180                 185                 190         


Gly Arg Ser Asp Asp Tyr Asp Ser Lys Lys Arg Lys Gln Arg Ala Gly 
        195                 200                 205             


Gly Glu Pro Trp Gly Ala Lys Lys Pro Arg His Asp Leu Pro Pro Tyr 
    210                 215                 220                 


Arg Val His Leu Xaa Pro Tyr Xaa Val Asp Ser Pro Ile Cys Asp Phe 
225                 230                 235                 240 


Leu Glu Leu Gln Arg Arg Tyr Arg Ser Leu Leu Val Pro Ser Asp Phe 
                245                 250                 255     


Leu Ser Val His Leu Ser Trp Leu Ser Ala Phe Pro Leu Ser Gln Pro 
            260                 265                 270         


Phe Ser Leu His His Pro Ser Arg Ile Gln Val Ser Ser Glu Lys Glu 
        275                 280                 285             


Ala Ala Pro Asp Ala Gly Ala Glu Pro Ile Xaa Ala Asp Ser Asp Pro 
    290                 295                 300                 


Ala Tyr Ser Ser Lys Val Leu Leu Leu Ser Ser Pro Gly Leu Glu Glu 
305                 310                 315                 320 


Leu Tyr Arg Cys Cys Met Leu Phe Val Asp Asp Met Ala Glu Pro Arg 
                325                 330                 335     


Glu Xaa Pro Glu His Pro Leu Lys Gln Ile Lys Phe Leu Leu Gly Arg 
            340                 345                 350         


Lys Glu Glu Glu Ala Val Leu Val Gly Gly Glu Trp Ser Pro Ser Leu 
        355                 360                 365             


Asp Gly Leu Asp Pro Gln Ala Asp Pro Gln Val Leu Val Arg Xaa Ala 
    370                 375                 380                 


Ile Arg Cys Ala Gln Ala Gln Xaa Gly Ile Asp Leu Ser Gly Cys Xaa 
385                 390                 395                 400 


Lys Trp Trp Arg Phe Ala Glu Phe Gln Tyr Leu Gln Pro Gly Pro Pro 
                405                 410                 415     


Arg Arg Leu Gln Xaa Val Val Val Tyr Leu Pro Asp Val Trp Xaa Ile 
            420                 425                 430         


Met Pro Xaa Leu Glu Glu Trp Glu Ala Leu Cys Gln Gln Lys Ala Ala 
        435                 440                 445             


Glu Ala Ala Pro Pro Xaa Gln Glu Ala Gln Gly Glu Xaa Glu Pro Xaa 
    450                 455                 460                 


Glu Gln Ala Pro Asp Ala Leu Glu Gln Ala Ala Asp Xaa Ser Arg Arg 
465                 470                 475                 480 


Asn Ala Glu Xaa Pro Glu Ala Xaa Xaa Gln Gln Glu Xaa Asp Xaa Asp 
                485                 490                 495     


Leu Pro Glu Ala Pro Pro Pro Pro Leu Glu Pro Ala Val Ile Ala Arg 
            500                 505                 510         


Pro Gly Cys Val Asn Leu Ser Leu His Gly Ile Val Glu Asp Arg Arg 
        515                 520                 525             


Pro Lys Glu Arg Ile Ser Phe Glu Val Met Val Leu Ala Glu Leu Phe 
    530                 535                 540                 


Leu Glu Met Leu Gln Arg Asp Phe Gly Tyr Arg Val Tyr Lys Met Leu 
545                 550                 555                 560 


Leu Ser Leu Pro Glu Lys Val Val Ser Pro Pro Glu Pro Glu Lys Glu 
                565                 570                 575     


Glu Ala Ala Lys Glu Glu Ala Xaa Lys Glu Glu Glu Ala Ile Lys Glu 
            580                 585                 590         


Glu Val Val Lys Glu Pro Lys Asp Glu Ala Gln Asn Glu Gly Pro Ala 
        595                 600                 605             


Xaa Glu Ser Glu Ala Pro Leu Lys Glu Asp Gly Leu Leu Pro Lys Pro 
    610                 615                 620                 


Leu Ser Ser Gly Gly Glu Glu Glu Glu Lys Pro Arg Gly Glu Ala Ser 
625                 630                 635                 640 


Glu Asp Leu Cys Glu Met Ala Leu Asp Pro Glu Leu Leu Leu Leu Arg 
                645                 650                 655     


Asp Asp Gly Glu Glu Glu Phe Ala Gly Ala Lys Leu Glu Asp Ser Glu 
            660                 665                 670         


Val Arg Ser Val Ala Ser Asn Gln Ser Glu Met Glu Phe Ser Ser Leu 
        675                 680                 685             


Gln Asp Met Pro Lys Glu Leu Asp Pro Ser Ala Val Leu Pro Leu Asp 
    690                 695                 700                 


Cys Leu Leu Ala Phe Val Phe Phe Asp Ala Asn Trp Cys Gly Tyr Leu 
705                 710                 715                 720 


His Arg Arg Asp Leu Glu Arg Ile Leu Leu Xaa Leu Gly Ile Arg Leu 
                725                 730                 735     


Ser Ala Glu Gln Ala Lys Gln Leu Val Ser Arg Val Val Xaa Gln Asn 
            740                 745                 750         


Ile Cys Gln Tyr Arg Ser Leu Gln Tyr Ser Arg Gln Glu Gly Leu Asp 
        755                 760                 765             


Gly Gly Leu Pro Glu Glu Val Leu Phe Gly Asn Leu Asp Leu Leu Pro 
    770                 775                 780                 


Pro Pro Gly Lys Ser Xaa Lys Pro Gly Ala Ala Pro Xaa Glu His Lys 
785                 790                 795                 800 


Ala Leu Val Ser His Asn Gly Ser Leu Ile Asn Val Gly Ser Leu Leu 
                805                 810                 815     


Gln Arg Ala Glu Gln Gln Asp Ser Gly Arg Leu Tyr Leu Glu Asn Lys 
            820                 825                 830         


Ile His Xaa Leu Glu Leu Lys Leu Glu Glu Ser His Asn Arg Phe Ser 
        835                 840                 845             


Ala Xaa Glu Val Xaa Asn Lys Xaa Leu Ala Ala Glu Met Gln Glu Leu 
    850                 855                 860                 


Arg Val Arg Leu Ala Glu Ala Glu Glu Xaa Ala Arg Xaa Ala Glu Arg 
865                 870                 875                 880 


Gln Lys Ser Gln Leu Gln Arg Leu Leu Gln Glu Leu Arg Arg Arg Leu 
                885                 890                 895     


Xaa Pro Leu Gln Leu Glu Ile Gln Arg Val Val Glu Lys Ala Asp Ser 
            900                 905                 910         


Trp Val Glu Lys Glu Glu Pro Ala Pro Ser Asn 
        915                 920             


<210> 5191
<211> 272
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<400> 5191
Met Val Leu Ala Glu Leu Phe Leu Glu Met Leu Gln Arg Asp Phe Gly 
1               5                   10                  15      


Tyr Arg Val Tyr Lys Met Leu Leu Ser Leu Pro Glu Lys Val Val Ser 
            20                  25                  30          


Pro Pro Glu Pro Glu Lys Glu Glu Ala Ala Lys Glu Glu Ala Xaa Lys 
        35                  40                  45              


Glu Glu Glu Ala Ile Lys Glu Glu Val Val Lys Glu Pro Lys Asp Glu 
    50                  55                  60                  


Ala Gln Asn Glu Gly Pro Ala Xaa Asp Phe Val Cys Leu Val Glu Gly 
65                  70                  75                  80  


Gly Trp Ala Phe Ala Lys Pro Leu Ser Ser Gly Gly Glu Glu Glu Glu 
                85                  90                  95      


Lys Pro Arg Gly Glu Ala Ser Glu Asp Leu Cys Glu Met Ala Leu Asp 
            100                 105                 110         


Pro Glu Leu Leu Leu Leu Arg Asp Asp Gly Glu Glu Glu Phe Ala Gly 
        115                 120                 125             


Ala Lys Leu Glu Asp Ser Glu Val Arg Ser Val Ala Ser Asn Gln Ser 
    130                 135                 140                 


Glu Met Glu Phe Ser Ser Leu Gln Asp Met Pro Lys Glu Leu Asp Pro 
145                 150                 155                 160 


Ser Ala Val Leu Pro Leu Asp Cys Leu Leu Ala Phe Val Phe Phe Asp 
                165                 170                 175     


Ala Asn Trp Cys Gly Tyr Leu His Arg Arg Asp Leu Glu Arg Ile Leu 
            180                 185                 190         


Leu Xaa Leu Gly Ile Arg Leu Ser Ala Glu Gln Ala Lys Gln Leu Val 
        195                 200                 205             


Ser Arg Val Val Xaa Gln Asn Ile Cys Gln Tyr Arg Ser Leu Gln Tyr 
    210                 215                 220                 


Ser Arg Gln Glu Gly Leu Asp Gly Gly Leu Pro Glu Glu Val Leu Phe 
225                 230                 235                 240 


Gly Asn Leu Asp Leu Leu Pro Pro Pro Gly Lys Ser Xaa Lys Pro Gly 
                245                 250                 255     


Cys Pro His Arg Xaa Gln Ser Leu Gly Val Pro Gln Trp Gln Pro Asp 
            260                 265                 270         


<210> 5192
<211> 277
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<400> 5192
Met Trp Phe Leu Xaa Val Gly Asp Gly Ser Xaa Ser Ser Asp Asp Tyr 
1               5                   10                  15      


Asp Ser Lys Lys Arg Lys Gln Arg Ala Gly Gly Glu Pro Trp Gly Ala 
            20                  25                  30          


Lys Lys Pro Arg His Asp Leu Pro Pro Tyr Arg Val His Leu Xaa Pro 
        35                  40                  45              


Tyr Xaa Val Asp Ser Pro Ile Cys Asp Phe Leu Glu Leu Gln Arg Arg 
    50                  55                  60                  


Tyr Arg Ser Leu Leu Val Pro Ser Asp Phe Leu Ser Val His Leu Ser 
65                  70                  75                  80  


Trp Leu Ser Ala Phe Pro Leu Ser Gln Pro Phe Ser Leu His His Pro 
                85                  90                  95      


Ser Arg Ile Gln Val Ser Ser Glu Lys Glu Ala Ala Pro Asp Ala Gly 
            100                 105                 110         


Ala Glu Pro Ile Xaa Ala Asp Ser Asp Pro Ala Tyr Ser Ser Lys Val 
        115                 120                 125             


Leu Leu Leu Ser Ser Pro Gly Leu Glu Glu Leu Tyr Arg Cys Cys Met 
    130                 135                 140                 


Leu Phe Val Asp Asp Met Ala Glu Pro Arg Glu Xaa Pro Glu His Pro 
145                 150                 155                 160 


Leu Lys Gln Ile Lys Phe Leu Leu Gly Arg Lys Glu Glu Glu Ala Val 
                165                 170                 175     


Leu Val Gly Gly Glu Trp Ser Pro Ser Leu Asp Gly Leu Asp Pro Gln 
            180                 185                 190         


Ala Asp Pro Gln Val Leu Val Arg Xaa Ala Ile Arg Cys Ala Gln Ala 
        195                 200                 205             


Gln Xaa Gly Ile Asp Leu Ser Gly Cys Xaa Lys Trp Trp Arg Phe Ala 
    210                 215                 220                 


Glu Phe Gln Tyr Leu Gln Pro Gly Pro Pro Arg Arg Leu Gln Xaa Val 
225                 230                 235                 240 


Val Val Tyr Leu Pro Asp Val Trp Xaa Ile Met Pro Xaa Leu Glu Glu 
                245                 250                 255     


Trp Glu Ala Leu Cys Gln Gln Lys Ala Ala Glu Ala Ala Pro Pro Xaa 
            260                 265                 270         


Gln Glu Ala Gln Gly 
        275         


<210> 5193
<211> 183
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<400> 5193
Xaa Leu Pro Val Ala Ala Ala Ala Ala Ala Val Val Val Pro Gly Val 
1               5                   10                  15      


Phe Val Pro Pro Val Ser Leu Pro Trp Pro Ala Gly Xaa Ala Ser Xaa 
            20                  25                  30          


Ser Leu Leu Gly Pro Pro Pro Gly Leu Leu Xaa Pro Pro Val Ala Xaa 
        35                  40                  45              


Glu Leu Ser Gln Asn Ala Arg His Leu Gln Gly Gly Glu Lys Gln Arg 
    50                  55                  60                  


Val Phe Xaa Gly Ile Val Xaa Ser Leu His Asp Tyr Phe Gly Val Val 
65                  70                  75                  80  


Asp Glu Glu Val Phe Phe Gln Leu Ser Val Val Lys Gly Arg Leu Pro 
                85                  90                  95      


Gln Leu Gly Glu Lys Val Leu Val Lys Ala Ala Tyr Asn Pro Gly Gln 
            100                 105                 110         


Ala Val Pro Trp Asn Ala Val Lys Val Gln Xaa Leu Ser Asn Gln Pro 
        115                 120                 125             


Leu Leu Lys Ser Pro Ala Pro Pro Leu Leu His Val Ala Ala Leu Gly 
    130                 135                 140                 


Gln Lys Gln Gly Ile Leu Gly Ala Gln Pro Gln Leu Ile Phe Gln Pro 
145                 150                 155                 160 


His Arg Ile Pro Pro Leu Phe Pro Gln Lys Pro Leu Ser Leu Phe Gln 
                165                 170                 175     


Xaa Ser His Xaa Leu His Leu 
            180             


<210> 5194
<211> 148
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<400> 5194
Xaa Leu Gln Gly Gly Glu Lys Gln Arg Val Phe Xaa Gly Ile Val Xaa 
1               5                   10                  15      


Ser Leu His Asp Tyr Phe Gly Val Val Asp Glu Glu Val Phe Phe Gln 
            20                  25                  30          


Leu Ser Val Val Lys Gly Arg Leu Pro Gln Leu Gly Glu Lys Val Leu 
        35                  40                  45              


Val Lys Ala Ala Tyr Asn Pro Gly Gln Ala Val Pro Trp Asn Ala Val 
    50                  55                  60                  


Lys Val Gln Xaa Leu Ser Asn Gln Pro Leu Leu Lys Ser Pro Ala Pro 
65                  70                  75                  80  


Pro Leu Leu His Val Ala Ala Leu Gly Gln Lys Gln Gly Ile Leu Gly 
                85                  90                  95      


Ala Gln Pro Gln Leu Ile Phe Gln Pro His Arg Ile Pro Pro Leu Phe 
            100                 105                 110         


Pro Gln Lys Pro Leu Ser Leu Phe Gln Xaa Ser His Xaa Leu His Leu 
        115                 120                 125             


Ser His Leu Asn Arg Phe Pro Ala Arg Gly Pro His Gly Arg Leu Asp 
    130                 135                 140                 


Gln Gly Arg Arg 
145             


<210> 5195
<211> 615
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<400> 5195
Xaa Val Leu Leu Leu Ser Ser Pro Gly Leu Glu Glu Leu Tyr Arg Cys 
1               5                   10                  15      


Cys Met Leu Phe Val Asp Asp Met Ala Glu Pro Arg Glu Xaa Pro Glu 
            20                  25                  30          


His Pro Leu Lys Gln Ile Lys Phe Leu Leu Gly Arg Lys Glu Glu Glu 
        35                  40                  45              


Ala Val Leu Val Gly Gly Glu Trp Ser Pro Ser Leu Asp Gly Leu Asp 
    50                  55                  60                  


Pro Gln Ala Asp Pro Gln Val Leu Val Arg Xaa Ala Ile Arg Cys Ala 
65                  70                  75                  80  


Gln Ala Gln Xaa Gly Ile Asp Leu Ser Gly Cys Xaa Lys Trp Trp Arg 
                85                  90                  95      


Phe Ala Glu Phe Gln Tyr Leu Gln Pro Gly Pro Pro Arg Arg Leu Gln 
            100                 105                 110         


Xaa Val Val Val Tyr Leu Pro Asp Val Trp Xaa Ile Met Pro Xaa Leu 
        115                 120                 125             


Glu Glu Trp Glu Ala Leu Cys Gln Gln Lys Ala Ala Glu Ala Ala Pro 
    130                 135                 140                 


Pro Xaa Gln Glu Ala Gln Gly Glu Xaa Glu Pro Xaa Glu Gln Ala Pro 
145                 150                 155                 160 


Asp Ala Leu Glu Gln Ala Ala Asp Xaa Ser Arg Arg Asn Ala Glu Xaa 
                165                 170                 175     


Pro Glu Ala Xaa Xaa Gln Gln Glu Xaa Asp Xaa Asp Leu Pro Glu Ala 
            180                 185                 190         


Pro Pro Pro Pro Leu Glu Pro Ala Val Ile Ala Arg Pro Gly Cys Val 
        195                 200                 205             


Asn Leu Ser Leu His Gly Ile Val Glu Asp Arg Arg Pro Lys Glu Arg 
    210                 215                 220                 


Ile Ser Phe Glu Val Met Val Leu Ala Glu Leu Phe Leu Glu Met Leu 
225                 230                 235                 240 


Gln Arg Asp Phe Gly Tyr Arg Val Tyr Lys Met Leu Leu Ser Leu Pro 
                245                 250                 255     


Glu Lys Val Val Ser Pro Pro Glu Pro Glu Lys Glu Glu Ala Ala Lys 
            260                 265                 270         


Glu Glu Ala Xaa Lys Glu Glu Glu Ala Ile Lys Glu Glu Val Val Lys 
        275                 280                 285             


Glu Pro Lys Asp Glu Ala Gln Asn Glu Gly Pro Ala Xaa Glu Ser Glu 
    290                 295                 300                 


Ala Pro Leu Lys Glu Asp Gly Leu Leu Pro Lys Pro Leu Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Glu Glu Glu Lys Pro Arg Gly Glu Ala Ser Glu Asp Leu Cys 
                325                 330                 335     


Glu Met Ala Leu Asp Pro Glu Leu Leu Leu Leu Arg Asp Asp Gly Glu 
            340                 345                 350         


Glu Glu Phe Ala Gly Ala Lys Leu Glu Asp Ser Glu Val Arg Ser Val 
        355                 360                 365             


Ala Ser Asn Gln Ser Glu Met Glu Phe Ser Ser Leu Gln Asp Met Pro 
    370                 375                 380                 


Lys Glu Leu Asp Pro Ser Ala Val Leu Pro Leu Asp Cys Leu Leu Ala 
385                 390                 395                 400 


Phe Val Phe Phe Asp Ala Asn Trp Cys Gly Tyr Leu His Arg Arg Asp 
                405                 410                 415     


Leu Glu Arg Ile Leu Leu Xaa Leu Gly Ile Arg Leu Ser Ala Glu Gln 
            420                 425                 430         


Ala Lys Gln Leu Val Ser Arg Val Val Xaa Gln Asn Ile Cys Gln Tyr 
        435                 440                 445             


Arg Ser Leu Gln Tyr Ser Arg Gln Glu Gly Leu Asp Gly Gly Leu Pro 
    450                 455                 460                 


Glu Glu Val Leu Phe Gly Asn Leu Asp Leu Leu Pro Pro Pro Gly Lys 
465                 470                 475                 480 


Ser Xaa Lys Pro Gly Ala Ala Pro Xaa Glu His Lys Ala Leu Val Ser 
                485                 490                 495     


His Asn Gly Ser Leu Ile Asn Val Gly Ser Leu Leu Gln Arg Ala Glu 
            500                 505                 510         


Gln Gln Asp Ser Gly Arg Leu Tyr Leu Glu Asn Lys Ile His Xaa Leu 
        515                 520                 525             


Glu Leu Lys Leu Glu Glu Ser His Asn Arg Phe Ser Ala Xaa Glu Val 
    530                 535                 540                 


Xaa Asn Lys Xaa Leu Ala Ala Glu Met Gln Glu Leu Arg Val Arg Leu 
545                 550                 555                 560 


Ala Glu Ala Glu Glu Xaa Ala Arg Xaa Ala Glu Arg Gln Lys Ser Gln 
                565                 570                 575     


Leu Gln Arg Leu Leu Gln Glu Leu Arg Arg Arg Leu Xaa Pro Leu Gln 
            580                 585                 590         


Leu Glu Ile Gln Arg Val Val Glu Lys Ala Asp Ser Trp Val Glu Lys 
        595                 600                 605             


Glu Glu Pro Ala Pro Ser Asn 
    610                 615 


<210> 5196
<211> 46
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<400> 5196
Met Val Lys Ala Gly Xaa Cys Cys Ala Xaa Cys Lys Glu Phe Tyr Gln 
1               5                   10                  15      


Met Lys Gln Xaa Val Leu Gln Leu Lys Gln Lys Ile Ala Leu Leu Pro 
            20                  25                  30          


Asn Asn Ala Ala Asp Leu Gly Lys Tyr Ile Xaa Gly Asp Lys 
        35                  40                  45      


<210> 5197
<211> 406
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<400> 5197
Met Val Pro Pro Pro Pro Ser Arg Gly Gly Ala Ala Arg Gly Gln Leu 
1               5                   10                  15      


Gly Arg Ser Leu Gly Pro Leu Leu Leu Leu Leu Ala Leu Gly His Xaa 
            20                  25                  30          


Trp Xaa Tyr Arg Glu Glu Pro Glu Asp Gly Asp Arg Glu Ile Cys Ser 
        35                  40                  45              


Glu Ser Lys Ile Ala Xaa Xaa Lys Tyr Pro Cys Leu Lys Ser Ser Gly 
    50                  55                  60                  


Glu Leu Xaa Xaa Cys Tyr Arg Lys Lys Cys Cys Lys Gly Tyr Lys Phe 
65                  70                  75                  80  


Val Leu Gly Gln Cys Ile Pro Glu Asp Tyr Asp Val Cys Ala Glu Ala 
                85                  90                  95      


Pro Cys Glu Gln Gln Cys Xaa Asp Asn Phe Gly Arg Val Leu Cys Xaa 
            100                 105                 110         


Cys Tyr Pro Gly Tyr Arg Tyr Asp Arg Glu Arg His Arg Lys Arg Glu 
        115                 120                 125             


Lys Pro Tyr Cys Leu Asp Ile Asp Glu Cys Ala Ser Ser Asn Gly Xaa 
    130                 135                 140                 


Leu Cys Ala His Ile Cys Ile Asn Xaa Leu Gly Ser Tyr Arg Cys Glu 
145                 150                 155                 160 


Cys Arg Glu Gly Tyr Ile Arg Glu Asp Asp Gly Lys Xaa Cys Xaa Arg 
                165                 170                 175     


Gly Asp Lys Tyr Pro Asn Asp Xaa Gly His Glu Lys Ser Glu Asn Met 
            180                 185                 190         


Val Lys Ala Gly Xaa Cys Cys Ala Xaa Cys Lys Glu Phe Tyr Gln Met 
        195                 200                 205             


Lys Gln Xaa Val Leu Gln Leu Lys Gln Lys Ile Ala Leu Leu Pro Asn 
    210                 215                 220                 


Asn Ala Ala Asp Leu Gly Lys Tyr Ile Xaa Gly Asp Lys Val Leu Ala 
225                 230                 235                 240 


Ser Asn Xaa Tyr Leu Pro Gly Pro Pro Gly Leu Pro Gly Gly Gln Gly 
                245                 250                 255     


Pro Pro Gly Ser Pro Gly Pro Lys Gly Ser Pro Gly Phe Pro Gly Met 
            260                 265                 270         


Pro Gly Pro Pro Gly Gln Pro Gly Pro Arg Gly Ser Met Gly Pro Met 
        275                 280                 285             


Gly Pro Ser Pro Asp Leu Ser His Ile Lys Gln Gly Arg Arg Gly Pro 
    290                 295                 300                 


Val Gly Pro Pro Gly Ala Pro Gly Arg Asp Gly Ser Lys Gly Glu Arg 
305                 310                 315                 320 


Gly Ala Pro Gly Pro Arg Gly Ser Pro Gly Pro Pro Gly Ser Phe Asp 
                325                 330                 335     


Phe Leu Leu Leu Met Leu Ala Asp Ile Arg Asn Asp Ile Xaa Glu Leu 
            340                 345                 350         


Gln Glu Lys Val Phe Gly His Arg Xaa His Ser Ser Ala Glu Glu Phe 
        355                 360                 365             


Pro Leu Pro Gln Glu Phe Pro Ser Tyr Pro Glu Ala Met Asp Leu Gly 
    370                 375                 380                 


Ser Gly Asp Asp His Pro Arg Arg Xaa Glu Xaa Arg Asp Leu Arg Ala 
385                 390                 395                 400 


Pro Arg Asp Phe Tyr Pro 
                405     


<210> 5198
<211> 336
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<400> 5198
Arg Lys Lys Cys Cys Lys Gly Tyr Lys Phe Val Leu Gly Gln Cys Ile 
1               5                   10                  15      


Pro Glu Asp Tyr Asp Val Cys Ala Glu Ala Pro Cys Glu Gln Gln Cys 
            20                  25                  30          


Xaa Asp Asn Phe Gly Arg Val Leu Cys Xaa Cys Tyr Pro Gly Tyr Arg 
        35                  40                  45              


Tyr Asp Arg Glu Arg His Arg Lys Arg Glu Lys Pro Tyr Cys Leu Asp 
    50                  55                  60                  


Ile Asp Glu Cys Ala Ser Ser Asn Gly Xaa Leu Cys Ala His Ile Cys 
65                  70                  75                  80  


Ile Asn Xaa Leu Gly Ser Tyr Arg Cys Glu Cys Arg Glu Gly Tyr Ile 
                85                  90                  95      


Arg Glu Asp Asp Gly Lys Xaa Cys Xaa Arg Gly Asp Lys Tyr Pro Asn 
            100                 105                 110         


Asp Xaa Gly His Glu Lys Ser Glu Asn Met Val Lys Ala Gly Xaa Cys 
        115                 120                 125             


Cys Ala Xaa Cys Lys Glu Phe Tyr Gln Met Lys Gln Xaa Val Leu Gln 
    130                 135                 140                 


Leu Lys Gln Lys Ile Ala Leu Leu Pro Asn Asn Ala Ala Asp Leu Gly 
145                 150                 155                 160 


Lys Tyr Ile Xaa Gly Asp Lys Val Leu Ala Ser Asn Xaa Tyr Leu Pro 
                165                 170                 175     


Gly Pro Pro Gly Leu Pro Gly Gly Gln Gly Pro Pro Gly Ser Pro Gly 
            180                 185                 190         


Pro Lys Gly Ser Pro Gly Phe Pro Gly Met Pro Gly Pro Pro Gly Gln 
        195                 200                 205             


Pro Gly Pro Arg Gly Ser Met Gly Pro Met Gly Pro Ser Pro Asp Leu 
    210                 215                 220                 


Ser His Ile Lys Gln Gly Arg Arg Gly Pro Val Gly Pro Pro Gly Ala 
225                 230                 235                 240 


Pro Gly Arg Asp Gly Ser Lys Gly Glu Arg Gly Ala Pro Gly Pro Arg 
                245                 250                 255     


Gly Ser Pro Gly Pro Pro Gly Ser Phe Asp Phe Leu Leu Leu Met Leu 
            260                 265                 270         


Ala Asp Ile Arg Asn Asp Ile Xaa Glu Leu Gln Glu Lys Val Phe Gly 
        275                 280                 285             


His Arg Xaa His Ser Ser Ala Glu Glu Phe Pro Leu Pro Gln Glu Phe 
    290                 295                 300                 


Pro Ser Tyr Pro Glu Ala Met Asp Leu Gly Ser Gly Asp Asp His Pro 
305                 310                 315                 320 


Arg Arg Xaa Glu Xaa Arg Asp Leu Arg Ala Pro Arg Asp Phe Tyr Pro 
                325                 330                 335     


<210> 5199
<211> 502
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(491)
<223> Selenocysteine

<400> 5199
Met Glu Xaa Leu Gln Glu Ser Leu Asn Xaa Leu Leu Lys Gln Leu Glu 
1               5                   10                  15      


Glu Glu Lys Lys Xaa Leu Glu Ser Gln Val Lys Tyr Tyr Ala Leu Lys 
            20                  25                  30          


Leu Glu Gln Glu Ser Lys Ala Tyr Gln Lys Ile Asn Asn Glu Arg Arg 
        35                  40                  45              


Xaa Tyr Leu Ala Glu Met Ser Gln Gly Ser Gly Leu His Gln Val Ser 
    50                  55                  60                  


Lys Arg Gln Gln Val Asp Gln Leu Pro Arg Met Gln Glu Asn Leu Val 
65                  70                  75                  80  


Lys Xaa Leu Leu Leu Lys Glu Glu Leu Asp Pro Leu Lys Ala Lys Ile 
                85                  90                  95      


Asp Ile Leu Leu Val Gly Asp Val Xaa Val Gly Tyr Leu Ala Asp Xaa 
            100                 105                 110         


Val Gln Lys Leu Phe Ala Asn Ile Ala Glu Val Xaa Ile Xaa Ile Ser 
        115                 120                 125             


Asp Xaa Lys Glu Ala Ala Ala Leu Leu Asp Asp Cys Ile Phe Asn Met 
    130                 135                 140                 


Val Leu Leu Lys Val Pro Ser Ser Leu Ser Ala Glu Glu Leu Glu Ala 
145                 150                 155                 160 


Ile Lys Leu Ile Arg Phe Gly Lys Lys Lys Asn Xaa His Ser Leu Phe 
                165                 170                 175     


Val Phe Ile Ile Pro Glu Asn Phe Lys Gly Cys Ile Ser Gly His Gly 
            180                 185                 190         


Met Asp Ile Ala Leu Xaa Glu Pro Leu Xaa Met Glu Lys Met Ser Asn 
        195                 200                 205             


Val Val Lys Tyr Trp Xaa Xaa Cys Pro Ser Asn Xaa Val Lys Xaa Glu 
    210                 215                 220                 


Asn Ala Xaa Gly Pro Glu Glu Leu Gly Leu Pro Leu Gln Arg Ser Tyr 
225                 230                 235                 240 


Ser Glu His Leu Gly Tyr Phe Pro Xaa Asp Leu Phe Ala Cys Ser Glu 
                245                 250                 255     


Ser Leu Arg Asn Gly Asn Gly Leu Glu Leu Asn Ala Ser Leu Ser Glu 
            260                 265                 270         


Phe Glu Lys Asn Lys Lys Ile Ser Leu Leu His Ser Ser Lys Glu Lys 
        275                 280                 285             


Leu Arg Arg Glu Arg Ile Lys Tyr Cys Cys Glu Gln Leu Arg Xaa Leu 
    290                 295                 300                 


Leu Pro Tyr Val Lys Gly Arg Lys Asn Asp Ala Ala Ser Val Leu Glu 
305                 310                 315                 320 


Ala Xaa Val Asp Tyr Val Lys Tyr Ile Arg Glu Lys Ile Ser Pro Ala 
                325                 330                 335     


Val Met Ala Gln Ile Xaa Glu Ala Leu Gln Ser Asn Met Arg Phe Cys 
            340                 345                 350         


Lys Lys Gln Gln Xaa Pro Ile Glu Leu Ser Leu Pro Gly Xaa Val Met 
        355                 360                 365             


Ala Gln Arg Glu Asn Ser Val Met Ser Xaa Tyr Ser Pro Glu Arg Gly 
    370                 375                 380                 


Leu Gln Phe Leu Xaa Asn Xaa Cys Trp Asn Gly Cys Ser Xaa Pro Asp 
385                 390                 395                 400 


Ala Glu Ser Ser Leu Asp Glu Ala Val Arg Val Pro Ser Ser Ser Ala 
                405                 410                 415     


Ser Glu Asn Ala Ile Gly Asp Pro Tyr Lys Xaa His Ile Ser Ser Ala 
            420                 425                 430         


Ala Leu Ser Leu Asn Ser Leu His Xaa Val Arg Tyr Tyr Ser Lys Val 
        435                 440                 445             


Xaa Pro Ser Tyr Asp Ala Xaa Ala Val Xaa Asn Gln Asn Ile Ser Ile 
    450                 455                 460                 


His Leu Pro Ser Ala Met Pro Pro Val Ser Lys Leu Leu Pro Arg His 
465                 470                 475                 480 


Cys Xaa Ser Gly Leu Gly Gln Xaa Cys Xaa Xaa His Pro Asn Cys Leu 
                485                 490                 495     


Gln Gln Phe Trp Ala Tyr 
            500         


<210> 5200
<211> 627
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<400> 5200
Met Glu Glu Ala Asp Arg Ile Leu Ile His Ser Leu Arg Gln Ala Gly 
1               5                   10                  15      


Xaa Ala Val Pro Pro Asp Val Gln Xaa Leu Arg Ala Phe Xaa Xaa Glu 
            20                  25                  30          


Leu Val Val Glu Ala Val Val Arg Cys Leu Arg Val Ile Asn Pro Ala 
        35                  40                  45              


Val Gly Ser Gly Leu Ser Pro Leu Leu Pro Leu Ala Met Ser Ala Arg 
    50                  55                  60                  


Phe Arg Leu Ala Met Ser Leu Ala Gln Ala Cys Met Asp Leu Gly Tyr 
65                  70                  75                  80  


Pro Leu Glu Leu Gly Tyr Gln Asn Phe Leu Tyr Pro Ser Glu Pro Asp 
                85                  90                  95      


Leu Arg Asp Leu Leu Leu Phe Leu Ala Glu Arg Leu Pro Xaa Asp Ala 
            100                 105                 110         


Ser Glu Asp Ala Asp Gln Pro Ala Gly Asp Ser Ala Ile Leu Leu Arg 
        115                 120                 125             


Ala Ile Gly Ser Gln Ile Arg Asp Gln Leu Ala Leu Pro Trp Val Pro 
    130                 135                 140                 


Pro His Leu Arg Xaa Pro Lys Leu Gln His Leu Gln Gly Ser Ala Leu 
145                 150                 155                 160 


Gln Lys Pro Phe His Ala Ser Arg Leu Val Val Pro Glu Leu Ser Ser 
                165                 170                 175     


Arg Gly Glu Pro Arg Glu Phe Gln Ala Ser Pro Leu Leu Leu Pro Val 
            180                 185                 190         


Pro Xaa Gln Val Pro Gln Pro Val Gly Arg Val Ala Ser Leu Leu Glu 
        195                 200                 205             


His His Ala Leu Gln Leu Cys Gln Gln Xaa Gly Arg Asp Arg Pro Gly 
    210                 215                 220                 


Asp Glu Asp Trp Val His Arg Xaa Ser Arg Leu Pro Pro Gln Glu Asp 
225                 230                 235                 240 


Xaa Arg Ala Gln Arg Gln Arg Leu Gln Lys Gln Leu Xaa Glu His Leu 
                245                 250                 255     


Arg Gln Ser Trp Gly Leu Leu Gly Ala Pro Ile Gln Ala Arg Asp Leu 
            260                 265                 270         


Gly Glu Leu Leu Gln Ala Trp Gly Ala Gly Ala Lys Xaa Gly Ala Pro 
        275                 280                 285             


Lys Gly Ser Arg Phe Xaa His Ser Glu Lys Phe Xaa Phe His Leu Glu 
    290                 295                 300                 


Pro Gln Ala Gln Ala Xaa Gln Val Ser Asp Val Pro Ala Xaa Ser Arg 
305                 310                 315                 320 


Arg Pro Glu Gln Val Xaa Trp Ala Ala Gln Glu Gln Glu Leu Glu Ser 
                325                 330                 335     


Leu Arg Glu Gln Leu Glu Gly Val Asn Arg Ser Ile Glu Glu Val Glu 
            340                 345                 350         


Ala Asp Met Lys Xaa Leu Gly Val Ser Phe Val Gln Ala Glu Ser Glu 
        355                 360                 365             


Cys Arg His Ser Lys Leu Ser Xaa Ala Glu Arg Glu Gln Ala Leu Arg 
    370                 375                 380                 


Leu Lys Ser Arg Ala Val Glu Leu Leu Pro Asp Gly Xaa Ala Asn Leu 
385                 390                 395                 400 


Ala Lys Leu Gln Leu Val Val Glu Asn Ser Ala Gln Arg Val Ile His 
                405                 410                 415     


Leu Ala Gly Gln Trp Glu Lys His Arg Val Pro Leu Leu Ala Glu Tyr 
            420                 425                 430         


Arg His Leu Arg Lys Leu Gln Asp Cys Arg Glu Leu Glu Ser Ser Arg 
        435                 440                 445             


Arg Leu Ala Glu Ile Gln Glu Leu His Gln Ser Val Arg Ala Ala Ala 
    450                 455                 460                 


Glu Glu Ala Arg Arg Lys Glu Glu Val Tyr Lys Gln Leu Met Ser Glu 
465                 470                 475                 480 


Leu Glu Xaa Leu Pro Arg Asp Val Ser Arg Leu Ala Tyr Xaa Gln Arg 
                485                 490                 495     


Ile Leu Glu Ile Val Gly Asn Ile Arg Lys Gln Lys Glu Glu Ile Xaa 
            500                 505                 510         


Lys Ile Leu Ser Asp Xaa Lys Glu Leu Gln Lys Glu Ile Asn Ser Leu 
        515                 520                 525             


Ser Gly Lys Leu Asp Arg Xaa Phe Ala Val Xaa Asp Glu Leu Val Phe 
    530                 535                 540                 


Lys Asp Ala Lys Lys Asp Asp Ala Val Arg Lys Ala Tyr Lys Tyr Leu 
545                 550                 555                 560 


Ala Ala Leu His Glu Asn Cys Ser Gln Leu Ile Gln Xaa Ile Glu Asp 
                565                 570                 575     


Xaa Gly Xaa Ile Met Arg Glu Val Arg Asp Leu Glu Glu Gln Ile Glu 
            580                 585                 590         


Xaa Glu Leu Gly Lys Lys Xaa Leu Ser Asn Leu Glu Lys Ile Arg Glu 
        595                 600                 605             


Asp Tyr Arg Ala Leu Arg Gln Glu Asn Ala Gly Leu Leu Gly Arg Val 
    610                 615                 620                 


Arg Glu Ala 
625         


<210> 5201
<211> 335
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<400> 5201
Met Xaa Xaa Val Xaa Val Xaa Xaa Glu Ile Pro Pro Arg Asp Lys Met 
1               5                   10                  15      


Glu Asp Asn Ser Ala Leu Tyr Glu Ser Xaa Ser Ala His Ile Ile Glu 
            20                  25                  30          


Glu Xaa Glu Tyr Val Lys Lys Ile Arg Xaa Xaa Leu Gln Lys Ile Arg 
        35                  40                  45              


Xaa Gln Met Phe Lys Asp Glu Ile Arg His Asp Ser Xaa Asn His Lys 
    50                  55                  60                  


Leu Asp Ala Lys His Cys Gly Asn Leu Gln Gln Gly Ser Asp Ser Glu 
65                  70                  75                  80  


Met Asp Pro Ser Cys Cys Ser Leu Asp Leu Leu Met Lys Lys Ile Lys 
                85                  90                  95      


Gly Lys Asp Leu Gln Leu Leu Glu Met Asn Lys Glu Asn Glu Val Leu 
            100                 105                 110         


Lys Ile Lys Leu Gln Ala Ser Arg Glu Ala Gly Ala Ala Ala Leu Arg 
        115                 120                 125             


Asn Val Ala Gln Arg Leu Phe Glu Asn Tyr Gln Xaa Gln Ser Glu Glu 
    130                 135                 140                 


Val Arg Lys Lys Gln Glu Asp Ser Lys Gln Leu Leu Gln Val Asn Lys 
145                 150                 155                 160 


Leu Glu Lys Glu Gln Lys Leu Lys Gln His Val Glu Asn Leu Asn Gln 
                165                 170                 175     


Val Ala Glu Lys Leu Glu Glu Lys His Ser Gln Ile Xaa Glu Leu Glu 
            180                 185                 190         


Asn Leu Val Gln Arg Met Glu Lys Glu Lys Arg Xaa Leu Leu Glu Arg 
        195                 200                 205             


Lys Leu Ser Leu Glu Asn Lys Leu Leu Gln Leu Lys Ser Ser Ala Xaa 
    210                 215                 220                 


Tyr Gly Lys Ser Cys Gln Asp Leu Gln Arg Glu Ile Ser Ile Leu Gln 
225                 230                 235                 240 


Glu Gln Ile Ser His Leu Gln Phe Val Ile His Ser Gln His Gln Asn 
                245                 250                 255     


Leu Arg Ser Val Ile Gln Glu Met Glu Gly Leu Lys Asn Asn Leu Lys 
            260                 265                 270         


Glu Gln Asp Lys Arg Ile Glu Asn Leu Arg Glu Lys Val Asn Ile Leu 
        275                 280                 285             


Glu Ala Gln Asn Lys Glu Leu Lys Xaa Gln Val Ala Leu Ser Ser Glu 
    290                 295                 300                 


Xaa Pro Arg Xaa Lys Val Ser Lys Ala Val Ser Xaa Ser Glu Leu Lys 
305                 310                 315                 320 


Xaa Glu Gly Val Ser Pro Tyr Leu Met Leu Ile Arg Leu Arg Lys 
                325                 330                 335 


<210> 5202
<211> 203
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<400> 5202
Xaa Leu Phe Glu Asn Tyr Gln Xaa Gln Ser Glu Glu Val Arg Lys Lys 
1               5                   10                  15      


Gln Glu Asp Ser Lys Gln Leu Leu Gln Val Asn Lys Leu Glu Lys Glu 
            20                  25                  30          


Gln Lys Leu Lys Gln His Val Glu Asn Leu Asn Gln Val Ala Glu Lys 
        35                  40                  45              


Leu Glu Glu Lys His Ser Gln Ile Xaa Glu Leu Glu Asn Leu Val Gln 
    50                  55                  60                  


Arg Met Glu Lys Glu Lys Arg Xaa Leu Leu Glu Arg Lys Leu Ser Leu 
65                  70                  75                  80  


Glu Asn Lys Leu Leu Gln Leu Lys Ser Ser Ala Xaa Tyr Gly Lys Ser 
                85                  90                  95      


Cys Gln Asp Leu Gln Arg Glu Ile Ser Ile Leu Gln Glu Gln Ile Ser 
            100                 105                 110         


His Leu Gln Phe Val Ile His Ser Gln His Gln Asn Leu Arg Ser Val 
        115                 120                 125             


Ile Gln Glu Met Glu Gly Leu Lys Asn Asn Leu Lys Glu Gln Asp Lys 
    130                 135                 140                 


Arg Ile Glu Asn Leu Arg Glu Lys Val Asn Ile Leu Glu Ala Gln Asn 
145                 150                 155                 160 


Lys Glu Leu Lys Xaa Gln Val Ala Leu Ser Ser Glu Xaa Pro Arg Xaa 
                165                 170                 175     


Lys Val Ser Lys Ala Val Ser Xaa Ser Glu Leu Lys Xaa Glu Gly Val 
            180                 185                 190         


Ser Pro Tyr Leu Met Leu Ile Arg Leu Arg Lys 
        195                 200             


<210> 5203
<211> 888
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(864)
<223> Selenocysteine

<400> 5203
Leu Leu Glu Ser Lys Leu Glu Ser Xaa Leu Lys Lys Ser Leu Glu Ile 
1               5                   10                  15      


Lys Glu Glu Lys Ile Ala Ala Leu Glu Ala Arg Leu Glu Glu Ser Xaa 
            20                  25                  30          


Asn Tyr Asn Gln Gln Leu Arg Gln Glu Leu Lys Xaa Val Lys Lys Asn 
        35                  40                  45              


Tyr Glu Ala Leu Lys Gln Arg Gln Asp Glu Glu Arg Met Val Gln Ser 
    50                  55                  60                  


Ser Pro Pro Ile Ser Gly Glu Asp Asn Lys Trp Glu Arg Glu Ser Gln 
65                  70                  75                  80  


Glu Xaa Xaa Arg Glu Leu Leu Lys Val Lys Asp Arg Leu Ile Glu Val 
                85                  90                  95      


Glu Arg Asn Asn Ala Xaa Leu Gln Ala Glu Lys Gln Ala Leu Lys Xaa 
            100                 105                 110         


Gln Leu Lys Gln Leu Glu Xaa Gln Asn Asn Asn Leu Gln Ala Gln Ile 
        115                 120                 125             


Leu Ala Leu Gln Arg Gln Xaa Val Ser Leu Gln Glu Gln Asn Xaa Xaa 
    130                 135                 140                 


Leu Gln Xaa Gln Asn Ala Lys Leu Gln Val Glu Asn Ser Xaa Leu Asn 
145                 150                 155                 160 


Ser Gln Ser Xaa Ser Leu Met Asn Gln Asn Ala Gln Leu Leu Ile Gln 
                165                 170                 175     


Gln Ser Ser Leu Glu Asn Glu Asn Glu Ser Val Ile Lys Glu Arg Glu 
            180                 185                 190         


Asp Leu Lys Ser Leu Tyr Asp Ser Leu Ile Lys Asp His Glu Lys Leu 
        195                 200                 205             


Glu Leu Leu His Glu Arg Gln Ala Ser Glu Tyr Glu Ser Leu Ile Ser 
    210                 215                 220                 


Lys His Gly Xaa Leu Lys Ser Ala His Lys Asn Leu Glu Val Glu His 
225                 230                 235                 240 


Arg Asp Leu Glu Asp Arg Tyr Asn Gln Leu Leu Lys Gln Lys Gly Gln 
                245                 250                 255     


Leu Glu Asp Leu Glu Lys Met Leu Lys Val Glu Gln Glu Lys Met Leu 
            260                 265                 270         


Leu Glu Asn Lys Asn His Glu Xaa Val Ala Ala Glu Tyr Lys Lys Leu 
        275                 280                 285             


Cys Gly Glu Asn Asp Arg Leu Asn His Xaa Tyr Ser Gln Leu Leu Lys 
    290                 295                 300                 


Glu Xaa Glu Val Leu Gln Xaa Asp His Lys Asn Leu Lys Ser Leu Leu 
305                 310                 315                 320 


Asn Asn Ser Lys Leu Glu Gln Xaa Arg Leu Glu Ala Glu Phe Ser Lys 
                325                 330                 335     


Leu Lys Glu Gln Tyr Gln Gln Leu Asp Ile Xaa Ser Xaa Lys Leu Asn 
            340                 345                 350         


Asn Gln Cys Glu Leu Leu Ser Gln Leu Lys Gly Asn Leu Glu Glu Glu 
        355                 360                 365             


Asn Arg His Leu Leu Asp Gln Ile Gln Xaa Leu Met Leu Gln Asn Arg 
    370                 375                 380                 


Xaa Leu Leu Glu Gln Asn Met Glu Ser Lys Asp Leu Phe His Val Glu 
385                 390                 395                 400 


Gln Arg Gln Tyr Ile Asp Lys Leu Asn Glu Leu Arg Arg Gln Lys Glu 
                405                 410                 415     


Lys Leu Glu Glu Lys Ile Met Asp Gln Tyr Lys Phe Tyr Asp Pro Ser 
            420                 425                 430         


Pro Pro Arg Arg Arg Gly Asn Trp Ile Xaa Leu Lys Met Arg Lys Leu 
        435                 440                 445             


Ile Lys Ser Lys Lys Asp Ile Asn Arg Glu Arg Gln Lys Ser Leu Xaa 
    450                 455                 460                 


Leu Xaa Pro Xaa Arg Ser Asp Ser Ser Glu Gly Phe Leu Gln Leu Pro 
465                 470                 475                 480 


His Gln Asp Ser Gln Asp Ser Ser Ser Val Gly Ser Asn Ser Leu Glu 
                485                 490                 495     


Asp Gly Gln Xaa Leu Gly Xaa Lys Lys Ser Ser Xaa Met Asn Asp Leu 
            500                 505                 510         


Val Gln Ser Met Val Leu Ala Gly Gln Trp Xaa Gly Ser Xaa Glu Asn 
        515                 520                 525             


Leu Glu Val Pro Asp Asp Ile Ser Xaa Gly Lys Arg Arg Lys Glu Leu 
    530                 535                 540                 


Gly Ala Met Ala Phe Ser Xaa Xaa Ala Ile Asn Phe Ser Xaa Val Asn 
545                 550                 555                 560 


Ser Ser Ala Gly Phe Arg Ser Lys Gln Leu Val Asn Asn Lys Asp Xaa 
                565                 570                 575     


Xaa Ser Phe Glu Asp Ile Ser Pro Gln Gly Val Ser Asp Asp Ser Ser 
            580                 585                 590         


Xaa Gly Ser Arg Val His Ala Ser Arg Pro Ala Ser Leu Asp Ser Gly 
        595                 600                 605             


Arg Xaa Ser Xaa Ser Asn Ser Asn Asn Asn Ala Ser Leu His Glu Val 
    610                 615                 620                 


Lys Ala Gly Ala Val Asn Asn Gln Ser Arg Pro Gln Ser His Ser Ser 
625                 630                 635                 640 


Gly Glu Phe Ser Leu Leu His Asp His Glu Ala Trp Ser Ser Ser Gly 
                645                 650                 655     


Ser Ser Pro Ile Gln Tyr Leu Lys Arg Gln Xaa Arg Ser Ser Pro Val 
            660                 665                 670         


Leu Gln His Lys Ile Ser Glu Xaa Leu Glu Ser Arg His His Lys Ile 
        675                 680                 685             


Lys Xaa Gly Ser Pro Gly Ser Glu Val Val Xaa Leu Gln Gln Phe Leu 
    690                 695                 700                 


Glu Glu Ser Asn Lys Leu Xaa Ser Val Gln Ile Lys Ser Ser Ser Gln 
705                 710                 715                 720 


Glu Asn Leu Leu Asp Glu Val Met Lys Ser Leu Ser Val Ser Ser Asp 
                725                 730                 735     


Phe Leu Gly Lys Asp Lys Pro Val Ser Cys Gly Leu Ala Arg Ser Val 
            740                 745                 750         


Ser Gly Lys Xaa Pro Gly Asp Phe Tyr Asp Arg Arg Xaa Xaa Lys Pro 
        755                 760                 765             


Glu Phe Leu Arg Pro Gly Pro Arg Lys Xaa Glu Asp Xaa Tyr Phe Ile 
    770                 775                 780                 


Ser Ser Ala Gly Lys Pro Xaa Pro Gly Xaa Gln Gly Lys Ile Lys Leu 
785                 790                 795                 800 


Val Lys Glu Ser Ser Leu Ser Arg Gln Ser Lys Asp Ser Asn Pro Tyr 
                805                 810                 815     


Ala Xaa Leu Pro Arg Ala Ser Ser Val Ile Ser Xaa Ala Glu Gly Xaa 
            820                 825                 830         


Xaa Arg Arg Xaa Ser Ile His Asp Phe Leu Xaa Lys Asp Ser Arg Leu 
        835                 840                 845             


Pro Ile Ser Val Asp Ser Pro Pro Ala Ala Ala Asp Ser Asn Xaa Xaa 
    850                 855                 860                 


Ala Ala Ser Asn Val Asp Lys Val Gln Glu Ser Arg Asn Ser Lys Ser 
865                 870                 875                 880 


Arg Ser Arg Glu Gln Gln Ser Ser 
                885             


<210> 5204
<211> 1796
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1066)..(1066)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1234)..(1234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1252)..(1252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1260)..(1260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1282)..(1282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1339)..(1339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1396)..(1396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1418)..(1418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1422)..(1422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1454)..(1454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1505)..(1505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1508)..(1508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1533)..(1534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1540)..(1540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1558)..(1559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1575)..(1575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1592)..(1592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1649)..(1649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1662)..(1662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1672)..(1672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1681)..(1681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1693)..(1693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1736)..(1736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1744)..(1744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1751)..(1751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1771)..(1772)
<223> Selenocysteine

<400> 5204
Met Glu Asn Glu Ile Phe Xaa Pro Leu Leu Glu Gln Phe Met Xaa Ser 
1               5                   10                  15      


Pro Leu Val Xaa Trp Val Lys Xaa Phe Gly Pro Leu Ala Ala Gly Asn 
            20                  25                  30          


Gly Xaa Asn Leu Asp Glu Tyr Val Ala Leu Val Asp Gly Val Phe Leu 
        35                  40                  45              


Asn Gln Val Met Leu Gln Ile Asn Pro Lys Leu Glu Ser Gln Arg Val 
    50                  55                  60                  


Asn Lys Lys Val Asn Asn Asp Ala Ser Leu Arg Met His Asn Leu Ser 
65                  70                  75                  80  


Ile Leu Val Arg Gln Ile Lys Phe Tyr Tyr Gln Glu Xaa Leu Gln Gln 
                85                  90                  95      


Leu Ile Met Met Ser Leu Pro Asn Val Leu Ile Ile Gly Lys Asn Pro 
            100                 105                 110         


Phe Ser Glu Gln Gly Xaa Glu Glu Val Lys Lys Leu Leu Leu Leu Leu 
        115                 120                 125             


Leu Gly Cys Ala Val Gln Cys Gln Lys Lys Glu Glu Phe Ile Glu Arg 
    130                 135                 140                 


Ile Gln Gly Leu Asp Phe Asp Xaa Lys Ala Ala Val Ala Ala His Ile 
145                 150                 155                 160 


Gln Glu Val Xaa His Asn Gln Glu Asn Val Phe Asp Leu Gln Trp Met 
                165                 170                 175     


Glu Val Xaa Asp Met Ser Gln Glu Asp Ile Glu Pro Leu Leu Lys Asn 
            180                 185                 190         


Met Ala Leu His Leu Lys Arg Leu Ile Asp Glu Arg Asp Glu His Ser 
        195                 200                 205             


Glu Xaa Ile Ile Glu Leu Ser Glu Glu Arg Asp Gly Leu His Phe Leu 
    210                 215                 220                 


Pro His Ala Ser Ser Ser Ala Gln Ser Pro Cys Gly Ser Pro Gly Met 
225                 230                 235                 240 


Lys Arg Xaa Glu Ser Arg Gln His Leu Ser Val Glu Leu Ala Asp Ala 
                245                 250                 255     


Lys Ala Lys Ile Arg Arg Leu Arg Gln Glu Leu Glu Glu Lys Xaa Glu 
            260                 265                 270         


Gln Leu Leu Asp Cys Lys Gln Glu Leu Glu Gln Met Glu Ile Glu Leu 
        275                 280                 285             


Lys Arg Leu Gln Gln Glu Asn Met Asn Leu Leu Ser Asp Ala Arg Ser 
    290                 295                 300                 


Ala Arg Met Tyr Arg Asp Glu Leu Asp Ala Leu Arg Glu Lys Ala Val 
305                 310                 315                 320 


Arg Val Asp Lys Leu Glu Ser Glu Val Ser Arg Tyr Lys Glu Arg Leu 
                325                 330                 335     


His Asp Ile Glu Phe Tyr Lys Ala Arg Val Glu Glu Leu Lys Glu Asp 
            340                 345                 350         


Asn Gln Val Leu Leu Glu Xaa Lys Xaa Met Leu Glu Asp Gln Leu Glu 
        355                 360                 365             


Gly Xaa Arg Ala Arg Ser Asp Lys Leu His Glu Leu Glu Lys Glu Asn 
    370                 375                 380                 


Leu Gln Leu Lys Ala Lys Leu His Asp Met Glu Met Glu Arg Asp Met 
385                 390                 395                 400 


Asp Arg Lys Lys Ile Glu Glu Leu Met Glu Glu Asn Met Xaa Leu Glu 
                405                 410                 415     


Met Ala Gln Lys Gln Ser Met Asp Glu Ser Leu His Leu Gly Trp Glu 
            420                 425                 430         


Leu Glu Gln Ile Ser Arg Xaa Ser Glu Leu Ser Glu Ala Pro Gln Lys 
        435                 440                 445             


Ser Leu Gly His Glu Val Asn Glu Leu Xaa Ser Ser Arg Leu Leu Lys 
    450                 455                 460                 


Leu Glu Met Glu Asn Gln Ser Leu Xaa Lys Xaa Val Glu Glu Leu Arg 
465                 470                 475                 480 


Xaa Xaa Val Asp Ser Val Glu Gly Asn Ala Ser Lys Ile Leu Lys Met 
                485                 490                 495     


Glu Lys Glu Asn Gln Arg Leu Ser Lys Lys Val Glu Ile Leu Glu Asn 
            500                 505                 510         


Glu Ile Val Gln Glu Lys Gln Ser Leu Gln Asn Cys Gln Asn Leu Ser 
        515                 520                 525             


Lys Asp Leu Met Lys Glu Lys Ala Gln Leu Glu Lys Xaa Ile Glu Xaa 
    530                 535                 540                 


Leu Arg Glu Asn Ser Glu Arg Gln Ile Lys Ile Leu Glu Gln Glu Asn 
545                 550                 555                 560 


Glu His Leu Asn Gln Xaa Val Ser Ser Leu Arg Gln Arg Ser Gln Ile 
                565                 570                 575     


Ser Ala Glu Ala Arg Val Lys Asp Ile Glu Lys Glu Asn Lys Ile Leu 
            580                 585                 590         


His Glu Ser Ile Lys Glu Xaa Ser Ser Lys Leu Ser Lys Ile Glu Phe 
        595                 600                 605             


Glu Lys Arg Gln Ile Lys Lys Glu Leu Glu His Tyr Lys Glu Lys Gly 
    610                 615                 620                 


Glu Arg Ala Glu Glu Leu Glu Asn Glu Leu His His Leu Glu Lys Glu 
625                 630                 635                 640 


Asn Glu Leu Leu Gln Lys Lys Ile Xaa Asn Leu Lys Ile Xaa Cys Glu 
                645                 650                 655     


Lys Ile Glu Ala Leu Glu Gln Glu Asn Ser Glu Leu Glu Arg Glu Asn 
            660                 665                 670         


Arg Lys Leu Lys Lys Xaa Leu Asp Ser Phe Lys Asn Leu Xaa Phe Gln 
        675                 680                 685             


Leu Glu Ser Leu Glu Lys Glu Asn Ser Gln Leu Asp Glu Glu Asn Leu 
    690                 695                 700                 


Glu Leu Arg Arg Asn Val Glu Ser Leu Lys Cys Ala Ser Met Lys Met 
705                 710                 715                 720 


Ala Gln Leu Gln Leu Glu Asn Lys Glu Leu Glu Ser Glu Lys Glu Gln 
                725                 730                 735     


Leu Lys Lys Gly Leu Glu Leu Leu Lys Ala Ser Phe Lys Lys Xaa Glu 
            740                 745                 750         


Arg Leu Glu Val Ser Tyr Gln Gly Leu Asp Ile Glu Asn Gln Arg Leu 
        755                 760                 765             


Gln Lys Xaa Leu Glu Asn Ser Asn Lys Lys Ile Gln Gln Leu Glu Ser 
    770                 775                 780                 


Glu Leu Gln Asp Leu Glu Met Glu Asn Gln Xaa Leu Gln Lys Asn Leu 
785                 790                 795                 800 


Glu Glu Leu Lys Ile Ser Ser Lys Arg Leu Glu Gln Leu Glu Lys Glu 
                805                 810                 815     


Asn Lys Ser Leu Glu Gln Glu Xaa Ser Gln Leu Glu Lys Asp Lys Lys 
            820                 825                 830         


Gln Leu Glu Lys Glu Asn Lys Arg Leu Arg Gln Gln Ala Glu Ile Lys 
        835                 840                 845             


Asp Xaa Xaa Leu Glu Glu Asn Asn Val Lys Ile Gly Asn Leu Glu Lys 
    850                 855                 860                 


Glu Asn Lys Xaa Leu Ser Lys Glu Ile Gly Ile Tyr Lys Glu Ser Cys 
865                 870                 875                 880 


Val Arg Leu Lys Glu Leu Glu Lys Glu Asn Lys Glu Leu Val Lys Arg 
                885                 890                 895     


Ala Xaa Ile Asp Ile Lys Xaa Leu Val Xaa Leu Arg Glu Asp Leu Val 
            900                 905                 910         


Ser Glu Lys Leu Lys Xaa Gln Gln Met Asn Asn Asp Leu Glu Lys Leu 
        915                 920                 925             


Xaa His Glu Leu Glu Lys Ile Gly Leu Asn Lys Glu Arg Leu Leu His 
    930                 935                 940                 


Asp Glu Gln Ser Xaa Asp Asp Arg Tyr Lys Leu Leu Glu Ser Lys Leu 
945                 950                 955                 960 


Glu Ser Xaa Leu Lys Lys Ser Leu Glu Ile Lys Glu Glu Lys Ile Ala 
                965                 970                 975     


Ala Leu Glu Ala Arg Leu Glu Glu Ser Xaa Asn Tyr Asn Gln Gln Leu 
            980                 985                 990         


Arg Gln Glu Leu Lys Xaa Val Lys  Lys Asn Tyr Glu Ala  Leu Lys Gln 
        995                 1000                 1005             


Arg Gln  Asp Glu Glu Arg Met  Val Gln Ser Ser Pro  Pro Ile Ser 
    1010                 1015                 1020             


Gly Glu  Asp Asn Lys Trp Glu  Arg Glu Ser Gln Glu  Xaa Xaa Arg 
    1025                 1030                 1035             


Glu Leu  Leu Lys Val Lys Asp  Arg Leu Ile Glu Val  Glu Arg Asn 
    1040                 1045                 1050             


Asn Ala  Xaa Leu Gln Ala Glu  Lys Gln Ala Leu Lys  Xaa Gln Leu 
    1055                 1060                 1065             


Lys Gln  Leu Glu Xaa Gln Asn  Asn Asn Leu Gln Ala  Gln Ile Leu 
    1070                 1075                 1080             


Ala Leu  Gln Arg Gln Xaa Val  Ser Leu Gln Glu Gln  Asn Xaa Xaa 
    1085                 1090                 1095             


Leu Gln  Xaa Gln Asn Ala Lys  Leu Gln Val Glu Asn  Ser Xaa Leu 
    1100                 1105                 1110             


Asn Ser  Gln Ser Xaa Ser Leu  Met Asn Gln Asn Ala  Gln Leu Leu 
    1115                 1120                 1125             


Ile Gln  Gln Ser Ser Leu Glu  Asn Glu Asn Glu Ser  Val Ile Lys 
    1130                 1135                 1140             


Glu Arg  Glu Asp Leu Lys Ser  Leu Tyr Asp Ser Leu  Ile Lys Asp 
    1145                 1150                 1155             


His Glu  Lys Leu Glu Leu Leu  His Glu Arg Gln Ala  Ser Glu Tyr 
    1160                 1165                 1170             


Glu Ser  Leu Ile Ser Lys His  Gly Xaa Leu Lys Ser  Ala His Lys 
    1175                 1180                 1185             


Asn Leu  Glu Val Glu His Arg  Asp Leu Glu Asp Arg  Tyr Asn Gln 
    1190                 1195                 1200             


Leu Leu  Lys Gln Lys Gly Gln  Leu Glu Asp Leu Glu  Lys Met Leu 
    1205                 1210                 1215             


Lys Val  Glu Gln Glu Lys Met  Leu Leu Glu Asn Lys  Asn His Glu 
    1220                 1225                 1230             


Xaa Val  Ala Ala Glu Tyr Lys  Lys Leu Cys Gly Glu  Asn Asp Arg 
    1235                 1240                 1245             


Leu Asn  His Xaa Tyr Ser Gln  Leu Leu Lys Glu Xaa  Glu Val Leu 
    1250                 1255                 1260             


Gln Xaa  Asp His Lys Asn Leu  Lys Ser Leu Leu Asn  Asn Ser Lys 
    1265                 1270                 1275             


Leu Glu  Gln Xaa Arg Leu Glu  Ala Glu Phe Ser Lys  Leu Lys Glu 
    1280                 1285                 1290             


Gln Tyr  Gln Gln Leu Asp Ile  Xaa Ser Xaa Lys Leu  Asn Asn Gln 
    1295                 1300                 1305             


Cys Glu  Leu Leu Ser Gln Leu  Lys Gly Asn Leu Glu  Glu Glu Asn 
    1310                 1315                 1320             


Arg His  Leu Leu Asp Gln Ile  Gln Xaa Leu Met Leu  Gln Asn Arg 
    1325                 1330                 1335             


Xaa Leu  Leu Glu Gln Asn Met  Glu Ser Lys Asp Leu  Phe His Val 
    1340                 1345                 1350             


Glu Gln  Arg Gln Tyr Ile Asp  Lys Leu Asn Glu Leu  Arg Arg Gln 
    1355                 1360                 1365             


Lys Glu  Lys Leu Glu Glu Lys  Ile Met Asp Gln Tyr  Lys Phe Tyr 
    1370                 1375                 1380             


Asp Pro  Ser Pro Pro Arg Arg  Arg Gly Asn Trp Ile  Xaa Leu Lys 
    1385                 1390                 1395             


Met Arg  Lys Leu Ile Lys Ser  Lys Lys Asp Ile Asn  Arg Glu Arg 
    1400                 1405                 1410             


Gln Lys  Ser Leu Xaa Leu Xaa  Pro Xaa Arg Ser Asp  Ser Ser Glu 
    1415                 1420                 1425             


Gly Phe  Leu Gln Leu Pro His  Gln Asp Ser Gln Asp  Ser Ser Ser 
    1430                 1435                 1440             


Val Gly  Ser Asn Ser Leu Glu  Asp Gly Gln Xaa Leu  Gly Xaa Lys 
    1445                 1450                 1455             


Lys Ser  Ser Met Val Ala Leu  Lys Arg Leu Pro Phe  Leu Arg Asn 
    1460                 1465                 1470             


Arg Pro  Lys Asp Lys Asp Lys  Met Lys Ala Cys Tyr  Arg Arg Ser 
    1475                 1480                 1485             


Met Ser  Met Asn Asp Leu Val  Gln Ser Met Val Leu  Ala Gly Gln 
    1490                 1495                 1500             


Trp Xaa  Gly Ser Xaa Glu Asn  Leu Glu Val Pro Asp  Asp Ile Ser 
    1505                 1510                 1515             


Xaa Gly  Lys Arg Arg Lys Glu  Leu Gly Ala Met Ala  Phe Ser Xaa 
    1520                 1525                 1530             


Xaa Ala  Ile Asn Phe Ser Xaa  Val Asn Ser Ser Ala  Gly Phe Arg 
    1535                 1540                 1545             


Ser Lys  Gln Leu Val Asn Asn  Lys Asp Xaa Xaa Ser  Phe Glu Asp 
    1550                 1555                 1560             


Ile Ser  Pro Gln Gly Val Ser  Asp Asp Ser Ser Xaa  Gly Ser Arg 
    1565                 1570                 1575             


Val His  Ala Ser Arg Pro Ala  Ser Leu Asp Ser Gly  Arg Xaa Ser 
    1580                 1585                 1590             


Xaa Ser  Asn Ser Asn Asn Asn  Ala Ser Leu His Glu  Val Lys Ala 
    1595                 1600                 1605             


Gly Ala  Val Asn Asn Gln Ser  Arg Pro Gln Ser His  Ser Ser Gly 
    1610                 1615                 1620             


Glu Phe  Ser Leu Leu His Asp  His Glu Ala Trp Ser  Ser Ser Gly 
    1625                 1630                 1635             


Ser Ser  Pro Ile Gln Tyr Leu  Lys Arg Gln Xaa Arg  Ser Ser Pro 
    1640                 1645                 1650             


Val Leu  Gln His Lys Ile Ser  Glu Xaa Leu Glu Ser  Arg His His 
    1655                 1660                 1665             


Lys Ile  Lys Xaa Gly Ser Pro  Gly Ser Glu Val Val  Xaa Leu Gln 
    1670                 1675                 1680             


Gln Phe  Leu Glu Glu Ser Asn  Lys Leu Xaa Ser Val  Gln Ile Lys 
    1685                 1690                 1695             


Ser Ser  Ser Gln Glu Asn Leu  Leu Asp Glu Val Met  Lys Ser Leu 
    1700                 1705                 1710             


Ser Val  Ser Ser Asp Phe Leu  Gly Lys Asp Lys Pro  Val Ser Cys 
    1715                 1720                 1725             


Gly Leu  Ala Ser Val Ile Ser  Xaa Ala Glu Gly Xaa  Xaa Arg Arg 
    1730                 1735                 1740             


Xaa Ser  Ile His Asp Phe Leu  Xaa Lys Asp Ser Arg  Leu Pro Ile 
    1745                 1750                 1755             


Ser Val  Asp Ser Pro Pro Ala  Ala Ala Asp Ser Asn  Xaa Xaa Ala 
    1760                 1765                 1770             


Ala Ser  Asn Val Asp Lys Val  Gln Glu Ser Arg Asn  Ser Lys Ser 
    1775                 1780                 1785             


Arg Ser  Arg Glu Gln Gln Ser  Ser 
    1790                 1795     


<210> 5205
<211> 1843
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1235)..(1235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1253)..(1253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1304)..(1304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1340)..(1340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1397)..(1397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1419)..(1419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1421)..(1421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1463)..(1463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1478)..(1478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1481)..(1481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1492)..(1492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1531)..(1532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1548)..(1548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1565)..(1565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1567)..(1567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1622)..(1622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1635)..(1635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1645)..(1645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1654)..(1654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1666)..(1666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1711)..(1711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1720)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1733)..(1733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1736)..(1736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1746)..(1746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1749)..(1749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1783)..(1783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1791)..(1791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1798)..(1798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1818)..(1819)
<223> Selenocysteine

<400> 5205
Met Glu Asn Glu Ile Phe Xaa Pro Leu Leu Glu Gln Phe Met Xaa Ser 
1               5                   10                  15      


Pro Leu Val Xaa Trp Val Lys Xaa Phe Gly Pro Leu Ala Ala Gly Asn 
            20                  25                  30          


Gly Xaa Asn Leu Asp Glu Tyr Val Ala Leu Val Asp Gly Val Phe Leu 
        35                  40                  45              


Asn Gln Val Met Leu Gln Ile Asn Pro Lys Leu Glu Ser Gln Arg Val 
    50                  55                  60                  


Asn Lys Lys Val Asn Asn Asp Ala Ser Leu Arg Met His Asn Leu Ser 
65                  70                  75                  80  


Ile Leu Val Arg Gln Ile Lys Phe Tyr Tyr Gln Glu Xaa Leu Gln Gln 
                85                  90                  95      


Leu Ile Met Met Ser Leu Pro Asn Val Leu Ile Ile Gly Lys Asn Pro 
            100                 105                 110         


Phe Ser Glu Gln Gly Xaa Glu Glu Val Lys Lys Leu Leu Leu Leu Leu 
        115                 120                 125             


Leu Gly Cys Ala Val Gln Cys Gln Lys Lys Glu Glu Phe Ile Glu Arg 
    130                 135                 140                 


Ile Gln Gly Leu Asp Phe Asp Xaa Lys Ala Ala Val Ala Ala His Ile 
145                 150                 155                 160 


Gln Glu Val Xaa His Asn Gln Glu Asn Val Phe Asp Leu Gln Trp Met 
                165                 170                 175     


Glu Val Xaa Asp Met Ser Gln Glu Asp Ile Glu Pro Leu Leu Lys Asn 
            180                 185                 190         


Met Ala Leu His Leu Lys Arg Leu Ile Asp Glu Arg Asp Glu His Ser 
        195                 200                 205             


Glu Xaa Ile Ile Glu Leu Ser Glu Glu Arg Asp Gly Leu His Phe Leu 
    210                 215                 220                 


Pro His Ala Ser Ser Ser Ala Gln Ser Pro Cys Gly Ser Pro Gly Met 
225                 230                 235                 240 


Lys Arg Xaa Glu Ser Arg Gln His Leu Ser Val Glu Leu Ala Asp Ala 
                245                 250                 255     


Lys Ala Lys Ile Arg Arg Leu Arg Gln Glu Leu Glu Glu Lys Xaa Glu 
            260                 265                 270         


Gln Leu Leu Asp Cys Lys Gln Glu Leu Glu Gln Met Glu Ile Glu Leu 
        275                 280                 285             


Lys Arg Leu Gln Gln Glu Asn Met Asn Leu Leu Ser Asp Ala Arg Ser 
    290                 295                 300                 


Ala Arg Met Tyr Arg Asp Glu Leu Asp Ala Leu Arg Glu Lys Ala Val 
305                 310                 315                 320 


Arg Val Asp Lys Leu Glu Ser Glu Val Ser Arg Tyr Lys Glu Arg Leu 
                325                 330                 335     


His Asp Ile Glu Phe Tyr Lys Ala Arg Val Glu Glu Leu Lys Glu Asp 
            340                 345                 350         


Asn Gln Val Leu Leu Glu Xaa Lys Xaa Met Leu Glu Asp Gln Leu Glu 
        355                 360                 365             


Gly Xaa Arg Ala Arg Ser Asp Lys Leu His Glu Leu Glu Lys Glu Asn 
    370                 375                 380                 


Leu Gln Leu Lys Ala Lys Leu His Asp Met Glu Met Glu Arg Asp Met 
385                 390                 395                 400 


Asp Arg Lys Lys Ile Glu Glu Leu Met Glu Glu Asn Met Xaa Leu Glu 
                405                 410                 415     


Met Ala Gln Lys Gln Ser Met Asp Glu Ser Leu His Leu Gly Trp Glu 
            420                 425                 430         


Leu Glu Gln Ile Ser Arg Xaa Ser Glu Leu Ser Glu Ala Pro Gln Lys 
        435                 440                 445             


Ser Leu Gly His Glu Val Asn Glu Leu Xaa Ser Ser Arg Leu Leu Lys 
    450                 455                 460                 


Leu Glu Met Glu Asn Gln Ser Leu Xaa Lys Xaa Val Glu Glu Leu Arg 
465                 470                 475                 480 


Xaa Xaa Val Asp Ser Val Glu Gly Asn Ala Ser Lys Ile Leu Lys Met 
                485                 490                 495     


Glu Lys Glu Asn Gln Arg Leu Ser Lys Lys Val Glu Ile Leu Glu Asn 
            500                 505                 510         


Glu Ile Val Gln Glu Lys Gln Ser Leu Gln Asn Cys Gln Asn Leu Ser 
        515                 520                 525             


Lys Asp Leu Met Lys Glu Lys Ala Gln Leu Glu Lys Xaa Ile Glu Xaa 
    530                 535                 540                 


Leu Arg Glu Asn Ser Glu Arg Gln Ile Lys Ile Leu Glu Gln Glu Asn 
545                 550                 555                 560 


Glu His Leu Asn Gln Xaa Val Ser Ser Leu Arg Gln Arg Ser Gln Ile 
                565                 570                 575     


Ser Ala Glu Ala Arg Val Lys Asp Ile Glu Lys Glu Asn Lys Ile Leu 
            580                 585                 590         


His Glu Ser Ile Lys Glu Xaa Ser Ser Lys Leu Ser Lys Ile Glu Phe 
        595                 600                 605             


Glu Lys Arg Gln Ile Lys Lys Glu Leu Glu His Tyr Lys Glu Lys Gly 
    610                 615                 620                 


Glu Arg Ala Glu Glu Leu Glu Asn Glu Leu His His Leu Glu Lys Glu 
625                 630                 635                 640 


Asn Glu Leu Leu Gln Lys Lys Ile Xaa Asn Leu Lys Ile Xaa Cys Glu 
                645                 650                 655     


Lys Ile Glu Ala Leu Glu Gln Glu Asn Ser Glu Leu Glu Arg Glu Asn 
            660                 665                 670         


Arg Lys Leu Lys Lys Xaa Leu Asp Ser Phe Lys Asn Leu Xaa Phe Gln 
        675                 680                 685             


Leu Glu Ser Leu Glu Lys Glu Asn Ser Gln Leu Asp Glu Glu Asn Leu 
    690                 695                 700                 


Glu Leu Arg Arg Asn Val Glu Ser Leu Lys Cys Ala Ser Met Lys Met 
705                 710                 715                 720 


Ala Gln Leu Gln Leu Glu Asn Lys Glu Leu Glu Ser Glu Lys Glu Gln 
                725                 730                 735     


Leu Lys Lys Gly Leu Glu Leu Leu Lys Ala Ser Phe Lys Lys Xaa Glu 
            740                 745                 750         


Arg Leu Glu Val Ser Tyr Gln Gly Leu Asp Ile Glu Asn Gln Arg Leu 
        755                 760                 765             


Gln Lys Xaa Leu Glu Asn Ser Asn Lys Lys Ile Gln Gln Leu Glu Ser 
    770                 775                 780                 


Glu Leu Gln Asp Leu Glu Met Glu Asn Gln Xaa Leu Gln Lys Asn Leu 
785                 790                 795                 800 


Glu Glu Leu Lys Ile Ser Ser Lys Arg Leu Glu Gln Leu Glu Lys Glu 
                805                 810                 815     


Asn Lys Ser Leu Glu Gln Glu Xaa Ser Gln Leu Glu Lys Asp Lys Lys 
            820                 825                 830         


Gln Leu Glu Lys Glu Asn Lys Arg Leu Arg Gln Gln Ala Glu Ile Lys 
        835                 840                 845             


Asp Xaa Xaa Leu Glu Glu Asn Asn Val Lys Ile Gly Asn Leu Glu Lys 
    850                 855                 860                 


Glu Asn Lys Xaa Leu Ser Lys Glu Ile Gly Ile Tyr Lys Glu Ser Cys 
865                 870                 875                 880 


Val Arg Leu Lys Glu Leu Glu Lys Glu Asn Lys Glu Leu Val Lys Arg 
                885                 890                 895     


Ala Xaa Ile Asp Ile Lys Xaa Leu Val Xaa Leu Arg Glu Asp Leu Val 
            900                 905                 910         


Ser Glu Lys Leu Lys Xaa Gln Gln Met Asn Asn Asp Leu Glu Lys Leu 
        915                 920                 925             


Xaa His Glu Leu Glu Lys Ile Gly Leu Asn Lys Glu Arg Leu Leu His 
    930                 935                 940                 


Asp Glu Gln Ser Xaa Asp Asp Ser Arg Tyr Lys Leu Leu Glu Ser Lys 
945                 950                 955                 960 


Leu Glu Ser Xaa Leu Lys Lys Ser Leu Glu Ile Lys Glu Glu Lys Ile 
                965                 970                 975     


Ala Ala Leu Glu Ala Arg Leu Glu Glu Ser Xaa Asn Tyr Asn Gln Gln 
            980                 985                 990         


Leu Arg Gln Glu Leu Lys Xaa Val  Lys Lys Asn Tyr Glu  Ala Leu Lys 
        995                 1000                 1005             


Gln Arg  Gln Asp Glu Glu Arg  Met Val Gln Ser Ser  Pro Pro Ile 
    1010                 1015                 1020             


Ser Gly  Glu Asp Asn Lys Trp  Glu Arg Glu Ser Gln  Glu Xaa Xaa 
    1025                 1030                 1035             


Arg Glu  Leu Leu Lys Val Lys  Asp Arg Leu Ile Glu  Val Glu Arg 
    1040                 1045                 1050             


Asn Asn  Ala Xaa Leu Gln Ala  Glu Lys Gln Ala Leu  Lys Xaa Gln 
    1055                 1060                 1065             


Leu Lys  Gln Leu Glu Xaa Gln  Asn Asn Asn Leu Gln  Ala Gln Ile 
    1070                 1075                 1080             


Leu Ala  Leu Gln Arg Gln Xaa  Val Ser Leu Gln Glu  Gln Asn Xaa 
    1085                 1090                 1095             


Xaa Leu  Gln Xaa Gln Asn Ala  Lys Leu Gln Val Glu  Asn Ser Xaa 
    1100                 1105                 1110             


Leu Asn  Ser Gln Ser Xaa Ser  Leu Met Asn Gln Asn  Ala Gln Leu 
    1115                 1120                 1125             


Leu Ile  Gln Gln Ser Ser Leu  Glu Asn Glu Asn Glu  Ser Val Ile 
    1130                 1135                 1140             


Lys Glu  Arg Glu Asp Leu Lys  Ser Leu Tyr Asp Ser  Leu Ile Lys 
    1145                 1150                 1155             


Asp His  Glu Lys Leu Glu Leu  Leu His Glu Arg Gln  Ala Ser Glu 
    1160                 1165                 1170             


Tyr Glu  Ser Leu Ile Ser Lys  His Gly Xaa Leu Lys  Ser Ala His 
    1175                 1180                 1185             


Lys Asn  Leu Glu Val Glu His  Arg Asp Leu Glu Asp  Arg Tyr Asn 
    1190                 1195                 1200             


Gln Leu  Leu Lys Gln Lys Gly  Gln Leu Glu Asp Leu  Glu Lys Met 
    1205                 1210                 1215             


Leu Lys  Val Glu Gln Glu Lys  Met Leu Leu Glu Asn  Lys Asn His 
    1220                 1225                 1230             


Glu Xaa  Val Ala Ala Glu Tyr  Lys Lys Leu Cys Gly  Glu Asn Asp 
    1235                 1240                 1245             


Arg Leu  Asn His Xaa Tyr Ser  Gln Leu Leu Lys Glu  Xaa Glu Val 
    1250                 1255                 1260             


Leu Gln  Xaa Asp His Lys Asn  Leu Lys Ser Leu Leu  Asn Asn Ser 
    1265                 1270                 1275             


Lys Leu  Glu Gln Xaa Arg Leu  Glu Ala Glu Phe Ser  Lys Leu Lys 
    1280                 1285                 1290             


Glu Gln  Tyr Gln Gln Leu Asp  Ile Xaa Ser Xaa Lys  Leu Asn Asn 
    1295                 1300                 1305             


Gln Cys  Glu Leu Leu Ser Gln  Leu Lys Gly Asn Leu  Glu Glu Glu 
    1310                 1315                 1320             


Asn Arg  His Leu Leu Asp Gln  Ile Gln Xaa Leu Met  Leu Gln Asn 
    1325                 1330                 1335             


Arg Xaa  Leu Leu Glu Gln Asn  Met Glu Ser Lys Asp  Leu Phe His 
    1340                 1345                 1350             


Val Glu  Gln Arg Gln Tyr Ile  Asp Lys Leu Asn Glu  Leu Arg Arg 
    1355                 1360                 1365             


Gln Lys  Glu Lys Leu Glu Glu  Lys Ile Met Asp Gln  Tyr Lys Phe 
    1370                 1375                 1380             


Tyr Asp  Pro Ser Pro Pro Arg  Arg Arg Gly Asn Trp  Ile Xaa Leu 
    1385                 1390                 1395             


Lys Met  Arg Lys Leu Ile Lys  Ser Lys Lys Asp Ile  Asn Arg Glu 
    1400                 1405                 1410             


Arg Gln  Lys Ser Leu Xaa Leu  Xaa Pro Xaa Arg Ser  Asp Ser Ser 
    1415                 1420                 1425             


Glu Gly  Phe Leu Gln Leu Pro  His Gln Asp Ser Gln  Asp Ser Ser 
    1430                 1435                 1440             


Ser Val  Gly Ser Asn Ser Leu  Glu Asp Gly Gln Xaa  Leu Gly Xaa 
    1445                 1450                 1455             


Lys Lys  Ser Ser Xaa Met Asn  Asp Leu Val Gln Ser  Met Val Leu 
    1460                 1465                 1470             


Ala Gly  Gln Trp Xaa Gly Ser  Xaa Glu Asn Leu Glu  Val Pro Asp 
    1475                 1480                 1485             


Asp Ile  Ser Xaa Gly Lys Arg  Arg Lys Glu Leu Gly  Ala Met Ala 
    1490                 1495                 1500             


Phe Ser  Xaa Xaa Ala Ile Asn  Phe Ser Xaa Val Asn  Ser Ser Ala 
    1505                 1510                 1515             


Gly Phe  Arg Ser Lys Gln Leu  Val Asn Asn Lys Asp  Xaa Xaa Ser 
    1520                 1525                 1530             


Phe Glu  Asp Ile Ser Pro Gln  Gly Val Ser Asp Asp  Ser Ser Xaa 
    1535                 1540                 1545             


Gly Ser  Arg Val His Ala Ser  Arg Pro Ala Ser Leu  Asp Ser Gly 
    1550                 1555                 1560             


Arg Xaa  Ser Xaa Ser Asn Ser  Asn Asn Asn Ala Ser  Leu His Glu 
    1565                 1570                 1575             


Val Lys  Ala Gly Ala Val Asn  Asn Gln Ser Arg Pro  Gln Ser His 
    1580                 1585                 1590             


Ser Ser  Gly Glu Phe Ser Leu  Leu His Asp His Glu  Ala Trp Ser 
    1595                 1600                 1605             


Ser Ser  Gly Ser Ser Pro Ile  Gln Tyr Leu Lys Arg  Gln Xaa Arg 
    1610                 1615                 1620             


Ser Ser  Pro Val Leu Gln His  Lys Ile Ser Glu Xaa  Leu Glu Ser 
    1625                 1630                 1635             


Arg His  His Lys Ile Lys Xaa  Gly Ser Pro Gly Ser  Glu Val Val 
    1640                 1645                 1650             


Xaa Leu  Gln Gln Phe Leu Glu  Glu Ser Asn Lys Leu  Xaa Ser Val 
    1655                 1660                 1665             


Gln Ile  Lys Ser Ser Ser Gln  Glu Asn Leu Leu Asp  Glu Val Met 
    1670                 1675                 1680             


Lys Ser  Leu Ser Val Ser Ser  Asp Phe Leu Gly Lys  Asp Lys Pro 
    1685                 1690                 1695             


Val Ser  Cys Gly Leu Ala Arg  Ser Val Ser Gly Lys  Xaa Pro Gly 
    1700                 1705                 1710             


Asp Phe  Tyr Asp Arg Arg Xaa  Xaa Lys Pro Glu Phe  Leu Arg Pro 
    1715                 1720                 1725             


Gly Pro  Arg Lys Xaa Glu Asp  Xaa Tyr Phe Ile Ser  Ser Ala Gly 
    1730                 1735                 1740             


Lys Pro  Xaa Pro Gly Xaa Gln  Gly Lys Ile Lys Leu  Val Lys Glu 
    1745                 1750                 1755             


Ser Ser  Leu Ser Arg Gln Ser  Lys Asp Ser Asn Pro  Tyr Ala Xaa 
    1760                 1765                 1770             


Leu Pro  Arg Ala Ser Ser Val  Ile Ser Xaa Ala Glu  Gly Xaa Xaa 
    1775                 1780                 1785             


Arg Arg  Xaa Ser Ile His Asp  Phe Leu Xaa Lys Asp  Ser Arg Leu 
    1790                 1795                 1800             


Pro Ile  Ser Val Asp Ser Pro  Pro Ala Ala Ala Asp  Ser Asn Xaa 
    1805                 1810                 1815             


Xaa Ala  Ala Ser Asn Val Asp  Lys Val Gln Glu Ser  Arg Asn Ser 
    1820                 1825                 1830             


Lys Ser  Arg Ser Arg Glu Gln  Gln Ser Ser 
    1835                 1840             


<210> 5206
<211> 1870
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1066)..(1066)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1234)..(1234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1252)..(1252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1260)..(1260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1282)..(1282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1339)..(1339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1396)..(1396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1418)..(1418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1422)..(1422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1454)..(1454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1505)..(1505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1508)..(1508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1533)..(1534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1540)..(1540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1558)..(1559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1575)..(1575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1592)..(1592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1649)..(1649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1662)..(1662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1672)..(1672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1681)..(1681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1693)..(1693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1738)..(1738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1747)..(1748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1763)..(1763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1773)..(1773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1776)..(1776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1800)..(1800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1810)..(1810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1814)..(1815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1818)..(1818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1825)..(1825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1845)..(1846)
<223> Selenocysteine

<400> 5206
Met Glu Asn Glu Ile Phe Xaa Pro Leu Leu Glu Gln Phe Met Xaa Ser 
1               5                   10                  15      


Pro Leu Val Xaa Trp Val Lys Xaa Phe Gly Pro Leu Ala Ala Gly Asn 
            20                  25                  30          


Gly Xaa Asn Leu Asp Glu Tyr Val Ala Leu Val Asp Gly Val Phe Leu 
        35                  40                  45              


Asn Gln Val Met Leu Gln Ile Asn Pro Lys Leu Glu Ser Gln Arg Val 
    50                  55                  60                  


Asn Lys Lys Val Asn Asn Asp Ala Ser Leu Arg Met His Asn Leu Ser 
65                  70                  75                  80  


Ile Leu Val Arg Gln Ile Lys Phe Tyr Tyr Gln Glu Xaa Leu Gln Gln 
                85                  90                  95      


Leu Ile Met Met Ser Leu Pro Asn Val Leu Ile Ile Gly Lys Asn Pro 
            100                 105                 110         


Phe Ser Glu Gln Gly Xaa Glu Glu Val Lys Lys Leu Leu Leu Leu Leu 
        115                 120                 125             


Leu Gly Cys Ala Val Gln Cys Gln Lys Lys Glu Glu Phe Ile Glu Arg 
    130                 135                 140                 


Ile Gln Gly Leu Asp Phe Asp Xaa Lys Ala Ala Val Ala Ala His Ile 
145                 150                 155                 160 


Gln Glu Val Xaa His Asn Gln Glu Asn Val Phe Asp Leu Gln Trp Met 
                165                 170                 175     


Glu Val Xaa Asp Met Ser Gln Glu Asp Ile Glu Pro Leu Leu Lys Asn 
            180                 185                 190         


Met Ala Leu His Leu Lys Arg Leu Ile Asp Glu Arg Asp Glu His Ser 
        195                 200                 205             


Glu Xaa Ile Ile Glu Leu Ser Glu Glu Arg Asp Gly Leu His Phe Leu 
    210                 215                 220                 


Pro His Ala Ser Ser Ser Ala Gln Ser Pro Cys Gly Ser Pro Gly Met 
225                 230                 235                 240 


Lys Arg Xaa Glu Ser Arg Gln His Leu Ser Val Glu Leu Ala Asp Ala 
                245                 250                 255     


Lys Ala Lys Ile Arg Arg Leu Arg Gln Glu Leu Glu Glu Lys Xaa Glu 
            260                 265                 270         


Gln Leu Leu Asp Cys Lys Gln Glu Leu Glu Gln Met Glu Ile Glu Leu 
        275                 280                 285             


Lys Arg Leu Gln Gln Glu Asn Met Asn Leu Leu Ser Asp Ala Arg Ser 
    290                 295                 300                 


Ala Arg Met Tyr Arg Asp Glu Leu Asp Ala Leu Arg Glu Lys Ala Val 
305                 310                 315                 320 


Arg Val Asp Lys Leu Glu Ser Glu Val Ser Arg Tyr Lys Glu Arg Leu 
                325                 330                 335     


His Asp Ile Glu Phe Tyr Lys Ala Arg Val Glu Glu Leu Lys Glu Asp 
            340                 345                 350         


Asn Gln Val Leu Leu Glu Xaa Lys Xaa Met Leu Glu Asp Gln Leu Glu 
        355                 360                 365             


Gly Xaa Arg Ala Arg Ser Asp Lys Leu His Glu Leu Glu Lys Glu Asn 
    370                 375                 380                 


Leu Gln Leu Lys Ala Lys Leu His Asp Met Glu Met Glu Arg Asp Met 
385                 390                 395                 400 


Asp Arg Lys Lys Ile Glu Glu Leu Met Glu Glu Asn Met Xaa Leu Glu 
                405                 410                 415     


Met Ala Gln Lys Gln Ser Met Asp Glu Ser Leu His Leu Gly Trp Glu 
            420                 425                 430         


Leu Glu Gln Ile Ser Arg Xaa Ser Glu Leu Ser Glu Ala Pro Gln Lys 
        435                 440                 445             


Ser Leu Gly His Glu Val Asn Glu Leu Xaa Ser Ser Arg Leu Leu Lys 
    450                 455                 460                 


Leu Glu Met Glu Asn Gln Ser Leu Xaa Lys Xaa Val Glu Glu Leu Arg 
465                 470                 475                 480 


Xaa Xaa Val Asp Ser Val Glu Gly Asn Ala Ser Lys Ile Leu Lys Met 
                485                 490                 495     


Glu Lys Glu Asn Gln Arg Leu Ser Lys Lys Val Glu Ile Leu Glu Asn 
            500                 505                 510         


Glu Ile Val Gln Glu Lys Gln Ser Leu Gln Asn Cys Gln Asn Leu Ser 
        515                 520                 525             


Lys Asp Leu Met Lys Glu Lys Ala Gln Leu Glu Lys Xaa Ile Glu Xaa 
    530                 535                 540                 


Leu Arg Glu Asn Ser Glu Arg Gln Ile Lys Ile Leu Glu Gln Glu Asn 
545                 550                 555                 560 


Glu His Leu Asn Gln Xaa Val Ser Ser Leu Arg Gln Arg Ser Gln Ile 
                565                 570                 575     


Ser Ala Glu Ala Arg Val Lys Asp Ile Glu Lys Glu Asn Lys Ile Leu 
            580                 585                 590         


His Glu Ser Ile Lys Glu Xaa Ser Ser Lys Leu Ser Lys Ile Glu Phe 
        595                 600                 605             


Glu Lys Arg Gln Ile Lys Lys Glu Leu Glu His Tyr Lys Glu Lys Gly 
    610                 615                 620                 


Glu Arg Ala Glu Glu Leu Glu Asn Glu Leu His His Leu Glu Lys Glu 
625                 630                 635                 640 


Asn Glu Leu Leu Gln Lys Lys Ile Xaa Asn Leu Lys Ile Xaa Cys Glu 
                645                 650                 655     


Lys Ile Glu Ala Leu Glu Gln Glu Asn Ser Glu Leu Glu Arg Glu Asn 
            660                 665                 670         


Arg Lys Leu Lys Lys Xaa Leu Asp Ser Phe Lys Asn Leu Xaa Phe Gln 
        675                 680                 685             


Leu Glu Ser Leu Glu Lys Glu Asn Ser Gln Leu Asp Glu Glu Asn Leu 
    690                 695                 700                 


Glu Leu Arg Arg Asn Val Glu Ser Leu Lys Cys Ala Ser Met Lys Met 
705                 710                 715                 720 


Ala Gln Leu Gln Leu Glu Asn Lys Glu Leu Glu Ser Glu Lys Glu Gln 
                725                 730                 735     


Leu Lys Lys Gly Leu Glu Leu Leu Lys Ala Ser Phe Lys Lys Xaa Glu 
            740                 745                 750         


Arg Leu Glu Val Ser Tyr Gln Gly Leu Asp Ile Glu Asn Gln Arg Leu 
        755                 760                 765             


Gln Lys Xaa Leu Glu Asn Ser Asn Lys Lys Ile Gln Gln Leu Glu Ser 
    770                 775                 780                 


Glu Leu Gln Asp Leu Glu Met Glu Asn Gln Xaa Leu Gln Lys Asn Leu 
785                 790                 795                 800 


Glu Glu Leu Lys Ile Ser Ser Lys Arg Leu Glu Gln Leu Glu Lys Glu 
                805                 810                 815     


Asn Lys Ser Leu Glu Gln Glu Xaa Ser Gln Leu Glu Lys Asp Lys Lys 
            820                 825                 830         


Gln Leu Glu Lys Glu Asn Lys Arg Leu Arg Gln Gln Ala Glu Ile Lys 
        835                 840                 845             


Asp Xaa Xaa Leu Glu Glu Asn Asn Val Lys Ile Gly Asn Leu Glu Lys 
    850                 855                 860                 


Glu Asn Lys Xaa Leu Ser Lys Glu Ile Gly Ile Tyr Lys Glu Ser Cys 
865                 870                 875                 880 


Val Arg Leu Lys Glu Leu Glu Lys Glu Asn Lys Glu Leu Val Lys Arg 
                885                 890                 895     


Ala Xaa Ile Asp Ile Lys Xaa Leu Val Xaa Leu Arg Glu Asp Leu Val 
            900                 905                 910         


Ser Glu Lys Leu Lys Xaa Gln Gln Met Asn Asn Asp Leu Glu Lys Leu 
        915                 920                 925             


Xaa His Glu Leu Glu Lys Ile Gly Leu Asn Lys Glu Arg Leu Leu His 
    930                 935                 940                 


Asp Glu Gln Ser Xaa Asp Asp Arg Tyr Lys Leu Leu Glu Ser Lys Leu 
945                 950                 955                 960 


Glu Ser Xaa Leu Lys Lys Ser Leu Glu Ile Lys Glu Glu Lys Ile Ala 
                965                 970                 975     


Ala Leu Glu Ala Arg Leu Glu Glu Ser Xaa Asn Tyr Asn Gln Gln Leu 
            980                 985                 990         


Arg Gln Glu Leu Lys Xaa Val Lys  Lys Asn Tyr Glu Ala  Leu Lys Gln 
        995                 1000                 1005             


Arg Gln  Asp Glu Glu Arg Met  Val Gln Ser Ser Pro  Pro Ile Ser 
    1010                 1015                 1020             


Gly Glu  Asp Asn Lys Trp Glu  Arg Glu Ser Gln Glu  Xaa Xaa Arg 
    1025                 1030                 1035             


Glu Leu  Leu Lys Val Lys Asp  Arg Leu Ile Glu Val  Glu Arg Asn 
    1040                 1045                 1050             


Asn Ala  Xaa Leu Gln Ala Glu  Lys Gln Ala Leu Lys  Xaa Gln Leu 
    1055                 1060                 1065             


Lys Gln  Leu Glu Xaa Gln Asn  Asn Asn Leu Gln Ala  Gln Ile Leu 
    1070                 1075                 1080             


Ala Leu  Gln Arg Gln Xaa Val  Ser Leu Gln Glu Gln  Asn Xaa Xaa 
    1085                 1090                 1095             


Leu Gln  Xaa Gln Asn Ala Lys  Leu Gln Val Glu Asn  Ser Xaa Leu 
    1100                 1105                 1110             


Asn Ser  Gln Ser Xaa Ser Leu  Met Asn Gln Asn Ala  Gln Leu Leu 
    1115                 1120                 1125             


Ile Gln  Gln Ser Ser Leu Glu  Asn Glu Asn Glu Ser  Val Ile Lys 
    1130                 1135                 1140             


Glu Arg  Glu Asp Leu Lys Ser  Leu Tyr Asp Ser Leu  Ile Lys Asp 
    1145                 1150                 1155             


His Glu  Lys Leu Glu Leu Leu  His Glu Arg Gln Ala  Ser Glu Tyr 
    1160                 1165                 1170             


Glu Ser  Leu Ile Ser Lys His  Gly Xaa Leu Lys Ser  Ala His Lys 
    1175                 1180                 1185             


Asn Leu  Glu Val Glu His Arg  Asp Leu Glu Asp Arg  Tyr Asn Gln 
    1190                 1195                 1200             


Leu Leu  Lys Gln Lys Gly Gln  Leu Glu Asp Leu Glu  Lys Met Leu 
    1205                 1210                 1215             


Lys Val  Glu Gln Glu Lys Met  Leu Leu Glu Asn Lys  Asn His Glu 
    1220                 1225                 1230             


Xaa Val  Ala Ala Glu Tyr Lys  Lys Leu Cys Gly Glu  Asn Asp Arg 
    1235                 1240                 1245             


Leu Asn  His Xaa Tyr Ser Gln  Leu Leu Lys Glu Xaa  Glu Val Leu 
    1250                 1255                 1260             


Gln Xaa  Asp His Lys Asn Leu  Lys Ser Leu Leu Asn  Asn Ser Lys 
    1265                 1270                 1275             


Leu Glu  Gln Xaa Arg Leu Glu  Ala Glu Phe Ser Lys  Leu Lys Glu 
    1280                 1285                 1290             


Gln Tyr  Gln Gln Leu Asp Ile  Xaa Ser Xaa Lys Leu  Asn Asn Gln 
    1295                 1300                 1305             


Cys Glu  Leu Leu Ser Gln Leu  Lys Gly Asn Leu Glu  Glu Glu Asn 
    1310                 1315                 1320             


Arg His  Leu Leu Asp Gln Ile  Gln Xaa Leu Met Leu  Gln Asn Arg 
    1325                 1330                 1335             


Xaa Leu  Leu Glu Gln Asn Met  Glu Ser Lys Asp Leu  Phe His Val 
    1340                 1345                 1350             


Glu Gln  Arg Gln Tyr Ile Asp  Lys Leu Asn Glu Leu  Arg Arg Gln 
    1355                 1360                 1365             


Lys Glu  Lys Leu Glu Glu Lys  Ile Met Asp Gln Tyr  Lys Phe Tyr 
    1370                 1375                 1380             


Asp Pro  Ser Pro Pro Arg Arg  Arg Gly Asn Trp Ile  Xaa Leu Lys 
    1385                 1390                 1395             


Met Arg  Lys Leu Ile Lys Ser  Lys Lys Asp Ile Asn  Arg Glu Arg 
    1400                 1405                 1410             


Gln Lys  Ser Leu Xaa Leu Xaa  Pro Xaa Arg Ser Asp  Ser Ser Glu 
    1415                 1420                 1425             


Gly Phe  Leu Gln Leu Pro His  Gln Asp Ser Gln Asp  Ser Ser Ser 
    1430                 1435                 1440             


Val Gly  Ser Asn Ser Leu Glu  Asp Gly Gln Xaa Leu  Gly Xaa Lys 
    1445                 1450                 1455             


Lys Ser  Ser Met Val Ala Leu  Lys Arg Leu Pro Phe  Leu Arg Asn 
    1460                 1465                 1470             


Arg Pro  Lys Asp Lys Asp Lys  Met Lys Ala Cys Tyr  Arg Arg Ser 
    1475                 1480                 1485             


Met Ser  Met Asn Asp Leu Val  Gln Ser Met Val Leu  Ala Gly Gln 
    1490                 1495                 1500             


Trp Xaa  Gly Ser Xaa Glu Asn  Leu Glu Val Pro Asp  Asp Ile Ser 
    1505                 1510                 1515             


Xaa Gly  Lys Arg Arg Lys Glu  Leu Gly Ala Met Ala  Phe Ser Xaa 
    1520                 1525                 1530             


Xaa Ala  Ile Asn Phe Ser Xaa  Val Asn Ser Ser Ala  Gly Phe Arg 
    1535                 1540                 1545             


Ser Lys  Gln Leu Val Asn Asn  Lys Asp Xaa Xaa Ser  Phe Glu Asp 
    1550                 1555                 1560             


Ile Ser  Pro Gln Gly Val Ser  Asp Asp Ser Ser Xaa  Gly Ser Arg 
    1565                 1570                 1575             


Val His  Ala Ser Arg Pro Ala  Ser Leu Asp Ser Gly  Arg Xaa Ser 
    1580                 1585                 1590             


Xaa Ser  Asn Ser Asn Asn Asn  Ala Ser Leu His Glu  Val Lys Ala 
    1595                 1600                 1605             


Gly Ala  Val Asn Asn Gln Ser  Arg Pro Gln Ser His  Ser Ser Gly 
    1610                 1615                 1620             


Glu Phe  Ser Leu Leu His Asp  His Glu Ala Trp Ser  Ser Ser Gly 
    1625                 1630                 1635             


Ser Ser  Pro Ile Gln Tyr Leu  Lys Arg Gln Xaa Arg  Ser Ser Pro 
    1640                 1645                 1650             


Val Leu  Gln His Lys Ile Ser  Glu Xaa Leu Glu Ser  Arg His His 
    1655                 1660                 1665             


Lys Ile  Lys Xaa Gly Ser Pro  Gly Ser Glu Val Val  Xaa Leu Gln 
    1670                 1675                 1680             


Gln Phe  Leu Glu Glu Ser Asn  Lys Leu Xaa Ser Val  Gln Ile Lys 
    1685                 1690                 1695             


Ser Ser  Ser Gln Glu Asn Leu  Leu Asp Glu Val Met  Lys Ser Leu 
    1700                 1705                 1710             


Ser Val  Ser Ser Asp Phe Leu  Gly Lys Asp Lys Pro  Val Ser Cys 
    1715                 1720                 1725             


Gly Leu  Ala Arg Ser Val Ser  Gly Lys Xaa Pro Gly  Asp Phe Tyr 
    1730                 1735                 1740             


Asp Arg  Arg Xaa Xaa Lys Pro  Glu Phe Leu Arg Pro  Gly Pro Arg 
    1745                 1750                 1755             


Lys Xaa  Glu Asp Xaa Tyr Phe  Ile Ser Ser Ala Gly  Lys Pro Xaa 
    1760                 1765                 1770             


Pro Gly  Xaa Gln Gly Lys Ile  Lys Leu Val Lys Glu  Ser Ser Leu 
    1775                 1780                 1785             


Ser Arg  Gln Ser Lys Asp Ser  Asn Pro Tyr Ala Xaa  Leu Pro Arg 
    1790                 1795                 1800             


Ala Ser  Ser Val Ile Ser Xaa  Ala Glu Gly Xaa Xaa  Arg Arg Xaa 
    1805                 1810                 1815             


Ser Ile  His Asp Phe Leu Xaa  Lys Asp Ser Arg Leu  Pro Ile Ser 
    1820                 1825                 1830             


Val Asp  Ser Pro Pro Ala Ala  Ala Asp Ser Asn Xaa  Xaa Ala Ala 
    1835                 1840                 1845             


Ser Asn  Val Asp Lys Val Gln  Glu Ser Arg Asn Ser  Lys Ser Arg 
    1850                 1855                 1860             


Ser Arg  Glu Gln Gln Ser Ser  
    1865                 1870 


<210> 5207
<211> 1871
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1235)..(1235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1253)..(1253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1304)..(1304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1340)..(1340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1397)..(1397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1419)..(1419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1421)..(1421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1423)..(1423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1509)..(1509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1520)..(1520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1534)..(1535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1541)..(1541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1559)..(1560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1576)..(1576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1593)..(1593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1595)..(1595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1650)..(1650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1663)..(1663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1673)..(1673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1682)..(1682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1694)..(1694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1739)..(1739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1748)..(1749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1764)..(1764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1774)..(1774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1777)..(1777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1801)..(1801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1811)..(1811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1815)..(1816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1819)..(1819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1826)..(1826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1846)..(1847)
<223> Selenocysteine

<400> 5207
Met Glu Asn Glu Ile Phe Xaa Pro Leu Leu Glu Gln Phe Met Xaa Ser 
1               5                   10                  15      


Pro Leu Val Xaa Trp Val Lys Xaa Phe Gly Pro Leu Ala Ala Gly Asn 
            20                  25                  30          


Gly Xaa Asn Leu Asp Glu Tyr Val Ala Leu Val Asp Gly Val Phe Leu 
        35                  40                  45              


Asn Gln Val Met Leu Gln Ile Asn Pro Lys Leu Glu Ser Gln Arg Val 
    50                  55                  60                  


Asn Lys Lys Val Asn Asn Asp Ala Ser Leu Arg Met His Asn Leu Ser 
65                  70                  75                  80  


Ile Leu Val Arg Gln Ile Lys Phe Tyr Tyr Gln Glu Xaa Leu Gln Gln 
                85                  90                  95      


Leu Ile Met Met Ser Leu Pro Asn Val Leu Ile Ile Gly Lys Asn Pro 
            100                 105                 110         


Phe Ser Glu Gln Gly Xaa Glu Glu Val Lys Lys Leu Leu Leu Leu Leu 
        115                 120                 125             


Leu Gly Cys Ala Val Gln Cys Gln Lys Lys Glu Glu Phe Ile Glu Arg 
    130                 135                 140                 


Ile Gln Gly Leu Asp Phe Asp Xaa Lys Ala Ala Val Ala Ala His Ile 
145                 150                 155                 160 


Gln Glu Val Xaa His Asn Gln Glu Asn Val Phe Asp Leu Gln Trp Met 
                165                 170                 175     


Glu Val Xaa Asp Met Ser Gln Glu Asp Ile Glu Pro Leu Leu Lys Asn 
            180                 185                 190         


Met Ala Leu His Leu Lys Arg Leu Ile Asp Glu Arg Asp Glu His Ser 
        195                 200                 205             


Glu Xaa Ile Ile Glu Leu Ser Glu Glu Arg Asp Gly Leu His Phe Leu 
    210                 215                 220                 


Pro His Ala Ser Ser Ser Ala Gln Ser Pro Cys Gly Ser Pro Gly Met 
225                 230                 235                 240 


Lys Arg Xaa Glu Ser Arg Gln His Leu Ser Val Glu Leu Ala Asp Ala 
                245                 250                 255     


Lys Ala Lys Ile Arg Arg Leu Arg Gln Glu Leu Glu Glu Lys Xaa Glu 
            260                 265                 270         


Gln Leu Leu Asp Cys Lys Gln Glu Leu Glu Gln Met Glu Ile Glu Leu 
        275                 280                 285             


Lys Arg Leu Gln Gln Glu Asn Met Asn Leu Leu Ser Asp Ala Arg Ser 
    290                 295                 300                 


Ala Arg Met Tyr Arg Asp Glu Leu Asp Ala Leu Arg Glu Lys Ala Val 
305                 310                 315                 320 


Arg Val Asp Lys Leu Glu Ser Glu Val Ser Arg Tyr Lys Glu Arg Leu 
                325                 330                 335     


His Asp Ile Glu Phe Tyr Lys Ala Arg Val Glu Glu Leu Lys Glu Asp 
            340                 345                 350         


Asn Gln Val Leu Leu Glu Xaa Lys Xaa Met Leu Glu Asp Gln Leu Glu 
        355                 360                 365             


Gly Xaa Arg Ala Arg Ser Asp Lys Leu His Glu Leu Glu Lys Glu Asn 
    370                 375                 380                 


Leu Gln Leu Lys Ala Lys Leu His Asp Met Glu Met Glu Arg Asp Met 
385                 390                 395                 400 


Asp Arg Lys Lys Ile Glu Glu Leu Met Glu Glu Asn Met Xaa Leu Glu 
                405                 410                 415     


Met Ala Gln Lys Gln Ser Met Asp Glu Ser Leu His Leu Gly Trp Glu 
            420                 425                 430         


Leu Glu Gln Ile Ser Arg Xaa Ser Glu Leu Ser Glu Ala Pro Gln Lys 
        435                 440                 445             


Ser Leu Gly His Glu Val Asn Glu Leu Xaa Ser Ser Arg Leu Leu Lys 
    450                 455                 460                 


Leu Glu Met Glu Asn Gln Ser Leu Xaa Lys Xaa Val Glu Glu Leu Arg 
465                 470                 475                 480 


Xaa Xaa Val Asp Ser Val Glu Gly Asn Ala Ser Lys Ile Leu Lys Met 
                485                 490                 495     


Glu Lys Glu Asn Gln Arg Leu Ser Lys Lys Val Glu Ile Leu Glu Asn 
            500                 505                 510         


Glu Ile Val Gln Glu Lys Gln Ser Leu Gln Asn Cys Gln Asn Leu Ser 
        515                 520                 525             


Lys Asp Leu Met Lys Glu Lys Ala Gln Leu Glu Lys Xaa Ile Glu Xaa 
    530                 535                 540                 


Leu Arg Glu Asn Ser Glu Arg Gln Ile Lys Ile Leu Glu Gln Glu Asn 
545                 550                 555                 560 


Glu His Leu Asn Gln Xaa Val Ser Ser Leu Arg Gln Arg Ser Gln Ile 
                565                 570                 575     


Ser Ala Glu Ala Arg Val Lys Asp Ile Glu Lys Glu Asn Lys Ile Leu 
            580                 585                 590         


His Glu Ser Ile Lys Glu Xaa Ser Ser Lys Leu Ser Lys Ile Glu Phe 
        595                 600                 605             


Glu Lys Arg Gln Ile Lys Lys Glu Leu Glu His Tyr Lys Glu Lys Gly 
    610                 615                 620                 


Glu Arg Ala Glu Glu Leu Glu Asn Glu Leu His His Leu Glu Lys Glu 
625                 630                 635                 640 


Asn Glu Leu Leu Gln Lys Lys Ile Xaa Asn Leu Lys Ile Xaa Cys Glu 
                645                 650                 655     


Lys Ile Glu Ala Leu Glu Gln Glu Asn Ser Glu Leu Glu Arg Glu Asn 
            660                 665                 670         


Arg Lys Leu Lys Lys Xaa Leu Asp Ser Phe Lys Asn Leu Xaa Phe Gln 
        675                 680                 685             


Leu Glu Ser Leu Glu Lys Glu Asn Ser Gln Leu Asp Glu Glu Asn Leu 
    690                 695                 700                 


Glu Leu Arg Arg Asn Val Glu Ser Leu Lys Cys Ala Ser Met Lys Met 
705                 710                 715                 720 


Ala Gln Leu Gln Leu Glu Asn Lys Glu Leu Glu Ser Glu Lys Glu Gln 
                725                 730                 735     


Leu Lys Lys Gly Leu Glu Leu Leu Lys Ala Ser Phe Lys Lys Xaa Glu 
            740                 745                 750         


Arg Leu Glu Val Ser Tyr Gln Gly Leu Asp Ile Glu Asn Gln Arg Leu 
        755                 760                 765             


Gln Lys Xaa Leu Glu Asn Ser Asn Lys Lys Ile Gln Gln Leu Glu Ser 
    770                 775                 780                 


Glu Leu Gln Asp Leu Glu Met Glu Asn Gln Xaa Leu Gln Lys Asn Leu 
785                 790                 795                 800 


Glu Glu Leu Lys Ile Ser Ser Lys Arg Leu Glu Gln Leu Glu Lys Glu 
                805                 810                 815     


Asn Lys Ser Leu Glu Gln Glu Xaa Ser Gln Leu Glu Lys Asp Lys Lys 
            820                 825                 830         


Gln Leu Glu Lys Glu Asn Lys Arg Leu Arg Gln Gln Ala Glu Ile Lys 
        835                 840                 845             


Asp Xaa Xaa Leu Glu Glu Asn Asn Val Lys Ile Gly Asn Leu Glu Lys 
    850                 855                 860                 


Glu Asn Lys Xaa Leu Ser Lys Glu Ile Gly Ile Tyr Lys Glu Ser Cys 
865                 870                 875                 880 


Val Arg Leu Lys Glu Leu Glu Lys Glu Asn Lys Glu Leu Val Lys Arg 
                885                 890                 895     


Ala Xaa Ile Asp Ile Lys Xaa Leu Val Xaa Leu Arg Glu Asp Leu Val 
            900                 905                 910         


Ser Glu Lys Leu Lys Xaa Gln Gln Met Asn Asn Asp Leu Glu Lys Leu 
        915                 920                 925             


Xaa His Glu Leu Glu Lys Ile Gly Leu Asn Lys Glu Arg Leu Leu His 
    930                 935                 940                 


Asp Glu Gln Ser Xaa Asp Asp Ser Arg Tyr Lys Leu Leu Glu Ser Lys 
945                 950                 955                 960 


Leu Glu Ser Xaa Leu Lys Lys Ser Leu Glu Ile Lys Glu Glu Lys Ile 
                965                 970                 975     


Ala Ala Leu Glu Ala Arg Leu Glu Glu Ser Xaa Asn Tyr Asn Gln Gln 
            980                 985                 990         


Leu Arg Gln Glu Leu Lys Xaa Val  Lys Lys Asn Tyr Glu  Ala Leu Lys 
        995                 1000                 1005             


Gln Arg  Gln Asp Glu Glu Arg  Met Val Gln Ser Ser  Pro Pro Ile 
    1010                 1015                 1020             


Ser Gly  Glu Asp Asn Lys Trp  Glu Arg Glu Ser Gln  Glu Xaa Xaa 
    1025                 1030                 1035             


Arg Glu  Leu Leu Lys Val Lys  Asp Arg Leu Ile Glu  Val Glu Arg 
    1040                 1045                 1050             


Asn Asn  Ala Xaa Leu Gln Ala  Glu Lys Gln Ala Leu  Lys Xaa Gln 
    1055                 1060                 1065             


Leu Lys  Gln Leu Glu Xaa Gln  Asn Asn Asn Leu Gln  Ala Gln Ile 
    1070                 1075                 1080             


Leu Ala  Leu Gln Arg Gln Xaa  Val Ser Leu Gln Glu  Gln Asn Xaa 
    1085                 1090                 1095             


Xaa Leu  Gln Xaa Gln Asn Ala  Lys Leu Gln Val Glu  Asn Ser Xaa 
    1100                 1105                 1110             


Leu Asn  Ser Gln Ser Xaa Ser  Leu Met Asn Gln Asn  Ala Gln Leu 
    1115                 1120                 1125             


Leu Ile  Gln Gln Ser Ser Leu  Glu Asn Glu Asn Glu  Ser Val Ile 
    1130                 1135                 1140             


Lys Glu  Arg Glu Asp Leu Lys  Ser Leu Tyr Asp Ser  Leu Ile Lys 
    1145                 1150                 1155             


Asp His  Glu Lys Leu Glu Leu  Leu His Glu Arg Gln  Ala Ser Glu 
    1160                 1165                 1170             


Tyr Glu  Ser Leu Ile Ser Lys  His Gly Xaa Leu Lys  Ser Ala His 
    1175                 1180                 1185             


Lys Asn  Leu Glu Val Glu His  Arg Asp Leu Glu Asp  Arg Tyr Asn 
    1190                 1195                 1200             


Gln Leu  Leu Lys Gln Lys Gly  Gln Leu Glu Asp Leu  Glu Lys Met 
    1205                 1210                 1215             


Leu Lys  Val Glu Gln Glu Lys  Met Leu Leu Glu Asn  Lys Asn His 
    1220                 1225                 1230             


Glu Xaa  Val Ala Ala Glu Tyr  Lys Lys Leu Cys Gly  Glu Asn Asp 
    1235                 1240                 1245             


Arg Leu  Asn His Xaa Tyr Ser  Gln Leu Leu Lys Glu  Xaa Glu Val 
    1250                 1255                 1260             


Leu Gln  Xaa Asp His Lys Asn  Leu Lys Ser Leu Leu  Asn Asn Ser 
    1265                 1270                 1275             


Lys Leu  Glu Gln Xaa Arg Leu  Glu Ala Glu Phe Ser  Lys Leu Lys 
    1280                 1285                 1290             


Glu Gln  Tyr Gln Gln Leu Asp  Ile Xaa Ser Xaa Lys  Leu Asn Asn 
    1295                 1300                 1305             


Gln Cys  Glu Leu Leu Ser Gln  Leu Lys Gly Asn Leu  Glu Glu Glu 
    1310                 1315                 1320             


Asn Arg  His Leu Leu Asp Gln  Ile Gln Xaa Leu Met  Leu Gln Asn 
    1325                 1330                 1335             


Arg Xaa  Leu Leu Glu Gln Asn  Met Glu Ser Lys Asp  Leu Phe His 
    1340                 1345                 1350             


Val Glu  Gln Arg Gln Tyr Ile  Asp Lys Leu Asn Glu  Leu Arg Arg 
    1355                 1360                 1365             


Gln Lys  Glu Lys Leu Glu Glu  Lys Ile Met Asp Gln  Tyr Lys Phe 
    1370                 1375                 1380             


Tyr Asp  Pro Ser Pro Pro Arg  Arg Arg Gly Asn Trp  Ile Xaa Leu 
    1385                 1390                 1395             


Lys Met  Arg Lys Leu Ile Lys  Ser Lys Lys Asp Ile  Asn Arg Glu 
    1400                 1405                 1410             


Arg Gln  Lys Ser Leu Xaa Leu  Xaa Pro Xaa Arg Ser  Asp Ser Ser 
    1415                 1420                 1425             


Glu Gly  Phe Leu Gln Leu Pro  His Gln Asp Ser Gln  Asp Ser Ser 
    1430                 1435                 1440             


Ser Val  Gly Ser Asn Ser Leu  Glu Asp Gly Gln Xaa  Leu Gly Xaa 
    1445                 1450                 1455             


Lys Lys  Ser Ser Met Val Ala  Leu Lys Arg Leu Pro  Phe Leu Arg 
    1460                 1465                 1470             


Asn Arg  Pro Lys Asp Lys Asp  Lys Met Lys Ala Cys  Tyr Arg Arg 
    1475                 1480                 1485             


Ser Met  Ser Met Asn Asp Leu  Val Gln Ser Met Val  Leu Ala Gly 
    1490                 1495                 1500             


Gln Trp  Xaa Gly Ser Xaa Glu  Asn Leu Glu Val Pro  Asp Asp Ile 
    1505                 1510                 1515             


Ser Xaa  Gly Lys Arg Arg Lys  Glu Leu Gly Ala Met  Ala Phe Ser 
    1520                 1525                 1530             


Xaa Xaa  Ala Ile Asn Phe Ser  Xaa Val Asn Ser Ser  Ala Gly Phe 
    1535                 1540                 1545             


Arg Ser  Lys Gln Leu Val Asn  Asn Lys Asp Xaa Xaa  Ser Phe Glu 
    1550                 1555                 1560             


Asp Ile  Ser Pro Gln Gly Val  Ser Asp Asp Ser Ser  Xaa Gly Ser 
    1565                 1570                 1575             


Arg Val  His Ala Ser Arg Pro  Ala Ser Leu Asp Ser  Gly Arg Xaa 
    1580                 1585                 1590             


Ser Xaa  Ser Asn Ser Asn Asn  Asn Ala Ser Leu His  Glu Val Lys 
    1595                 1600                 1605             


Ala Gly  Ala Val Asn Asn Gln  Ser Arg Pro Gln Ser  His Ser Ser 
    1610                 1615                 1620             


Gly Glu  Phe Ser Leu Leu His  Asp His Glu Ala Trp  Ser Ser Ser 
    1625                 1630                 1635             


Gly Ser  Ser Pro Ile Gln Tyr  Leu Lys Arg Gln Xaa  Arg Ser Ser 
    1640                 1645                 1650             


Pro Val  Leu Gln His Lys Ile  Ser Glu Xaa Leu Glu  Ser Arg His 
    1655                 1660                 1665             


His Lys  Ile Lys Xaa Gly Ser  Pro Gly Ser Glu Val  Val Xaa Leu 
    1670                 1675                 1680             


Gln Gln  Phe Leu Glu Glu Ser  Asn Lys Leu Xaa Ser  Val Gln Ile 
    1685                 1690                 1695             


Lys Ser  Ser Ser Gln Glu Asn  Leu Leu Asp Glu Val  Met Lys Ser 
    1700                 1705                 1710             


Leu Ser  Val Ser Ser Asp Phe  Leu Gly Lys Asp Lys  Pro Val Ser 
    1715                 1720                 1725             


Cys Gly  Leu Ala Arg Ser Val  Ser Gly Lys Xaa Pro  Gly Asp Phe 
    1730                 1735                 1740             


Tyr Asp  Arg Arg Xaa Xaa Lys  Pro Glu Phe Leu Arg  Pro Gly Pro 
    1745                 1750                 1755             


Arg Lys  Xaa Glu Asp Xaa Tyr  Phe Ile Ser Ser Ala  Gly Lys Pro 
    1760                 1765                 1770             


Xaa Pro  Gly Xaa Gln Gly Lys  Ile Lys Leu Val Lys  Glu Ser Ser 
    1775                 1780                 1785             


Leu Ser  Arg Gln Ser Lys Asp  Ser Asn Pro Tyr Ala  Xaa Leu Pro 
    1790                 1795                 1800             


Arg Ala  Ser Ser Val Ile Ser  Xaa Ala Glu Gly Xaa  Xaa Arg Arg 
    1805                 1810                 1815             


Xaa Ser  Ile His Asp Phe Leu  Xaa Lys Asp Ser Arg  Leu Pro Ile 
    1820                 1825                 1830             


Ser Val  Asp Ser Pro Pro Ala  Ala Ala Asp Ser Asn  Xaa Xaa Ala 
    1835                 1840                 1845             


Ala Ser  Asn Val Asp Lys Val  Gln Glu Ser Arg Asn  Ser Lys Ser 
    1850                 1855                 1860             


Arg Ser  Arg Glu Gln Gln Ser  Ser 
    1865                 1870     


<210> 5208
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<400> 5208
Met His Asn Leu Ser Ile Leu Val Arg Gln Ile Lys Phe Tyr Tyr Gln 
1               5                   10                  15      


Glu Xaa Leu Gln Gln Leu Ile Met Met Ser Leu Pro Asn Val Leu Ile 
            20                  25                  30          


Ile Gly Lys Asn Pro Phe Ser Glu Gln Gly Xaa Glu Glu Val Lys Lys 
        35                  40                  45              


Leu Leu Leu Leu Leu Leu Gly Cys Ala Val Gln Cys Gln Lys Lys Glu 
    50                  55                  60                  


Glu Phe Ile Glu Arg Ile Gln Gly Leu Asp Phe Asp Xaa Lys Ala Ala 
65                  70                  75                  80  


Val Ala Ala His Ile Gln Glu Val Xaa His Asn Gln Glu Asn Val Phe 
                85                  90                  95      


Asp Leu Gln Trp Met Glu Val Xaa Asp Met Ser Gln Glu Asp Ile Glu 
            100                 105                 110         


Pro Leu Leu Lys Asn Met Ala Leu His Leu Lys Arg Leu Ile Asp Glu 
        115                 120                 125             


Arg Asp Glu His Ser Glu Xaa Ile Ile Glu Leu Ser Glu Glu Arg Asp 
    130                 135                 140                 


Gly Leu His 
145         


<210> 5209
<211> 741
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<400> 5209
Met His Asn Leu Ser Ile Leu Val Arg Gln Ile Lys Phe Tyr Tyr Gln 
1               5                   10                  15      


Glu Xaa Leu Gln Gln Leu Ile Met Met Ser Leu Pro Asn Val Leu Ile 
            20                  25                  30          


Ile Gly Lys Asn Pro Phe Ser Glu Gln Gly Xaa Glu Glu Val Lys Lys 
        35                  40                  45              


Leu Leu Leu Leu Leu Leu Gly Cys Ala Val Gln Cys Gln Lys Lys Glu 
    50                  55                  60                  


Glu Phe Ile Glu Arg Ile Gln Gly Leu Asp Phe Asp Xaa Lys Ala Ala 
65                  70                  75                  80  


Val Ala Ala His Ile Gln Glu Val Xaa His Asn Gln Glu Asn Val Phe 
                85                  90                  95      


Asp Leu Gln Trp Met Glu Val Xaa Asp Met Ser Gln Glu Asp Ile Glu 
            100                 105                 110         


Pro Leu Leu Lys Asn Met Ala Leu His Leu Lys Arg Leu Ile Asp Glu 
        115                 120                 125             


Arg Asp Glu His Ser Glu Xaa Ile Ile Glu Leu Ser Glu Glu Arg Asp 
    130                 135                 140                 


Gly Leu His Phe Leu Pro His Ala Ser Ser Ser Ala Gln Ser Pro Cys 
145                 150                 155                 160 


Gly Ser Pro Gly Met Lys Arg Xaa Glu Ser Arg Gln His Leu Ser Val 
                165                 170                 175     


Glu Leu Ala Asp Ala Lys Ala Lys Ile Arg Arg Leu Arg Gln Glu Leu 
            180                 185                 190         


Glu Glu Lys Xaa Glu Gln Leu Leu Asp Cys Lys Gln Glu Leu Glu Gln 
        195                 200                 205             


Met Glu Ile Glu Leu Lys Arg Leu Gln Gln Glu Asn Met Asn Leu Leu 
    210                 215                 220                 


Ser Asp Ala Arg Ser Ala Arg Met Tyr Arg Asp Glu Leu Asp Ala Leu 
225                 230                 235                 240 


Arg Glu Lys Ala Val Arg Val Asp Lys Leu Glu Ser Glu Val Ser Arg 
                245                 250                 255     


Tyr Lys Glu Arg Leu His Asp Ile Glu Phe Tyr Lys Ala Arg Val Glu 
            260                 265                 270         


Glu Leu Lys Glu Asp Asn Gln Val Leu Leu Glu Xaa Lys Xaa Met Leu 
        275                 280                 285             


Glu Asp Gln Leu Glu Gly Xaa Arg Ala Arg Ser Asp Lys Leu His Glu 
    290                 295                 300                 


Leu Glu Lys Glu Asn Leu Gln Leu Lys Ala Lys Leu His Asp Met Glu 
305                 310                 315                 320 


Met Glu Arg Asp Met Asp Arg Lys Lys Ile Glu Glu Leu Met Glu Glu 
                325                 330                 335     


Asn Met Xaa Leu Glu Met Ala Gln Lys Gln Ser Met Asp Glu Ser Leu 
            340                 345                 350         


His Leu Gly Trp Glu Leu Glu Gln Ile Ser Arg Xaa Ser Glu Leu Ser 
        355                 360                 365             


Glu Ala Pro Gln Lys Ser Leu Gly His Glu Val Asn Glu Leu Xaa Ser 
    370                 375                 380                 


Ser Arg Leu Leu Lys Leu Glu Met Glu Asn Gln Ser Leu Xaa Lys Xaa 
385                 390                 395                 400 


Val Glu Glu Leu Arg Xaa Xaa Val Asp Ser Val Glu Gly Asn Ala Ser 
                405                 410                 415     


Lys Ile Leu Lys Met Glu Lys Glu Asn Gln Arg Leu Ser Lys Lys Val 
            420                 425                 430         


Glu Ile Leu Glu Asn Glu Ile Val Gln Glu Lys Gln Ser Leu Gln Asn 
        435                 440                 445             


Cys Gln Asn Leu Ser Lys Asp Leu Met Lys Glu Lys Ala Gln Leu Glu 
    450                 455                 460                 


Lys Xaa Ile Glu Xaa Leu Arg Glu Asn Ser Glu Arg Gln Ile Lys Ile 
465                 470                 475                 480 


Leu Glu Gln Glu Asn Glu His Leu Asn Gln Xaa Val Ser Ser Leu Arg 
                485                 490                 495     


Gln Arg Ser Gln Ile Ser Ala Glu Ala Arg Val Lys Asp Ile Glu Lys 
            500                 505                 510         


Glu Asn Lys Ile Leu His Glu Ser Ile Lys Glu Xaa Ser Ser Lys Leu 
        515                 520                 525             


Ser Lys Ile Glu Phe Glu Lys Arg Gln Ile Lys Lys Glu Leu Glu His 
    530                 535                 540                 


Tyr Lys Glu Lys Gly Glu Arg Ala Glu Glu Leu Glu Asn Glu Leu His 
545                 550                 555                 560 


His Leu Glu Lys Glu Asn Glu Leu Leu Gln Lys Lys Ile Xaa Asn Leu 
                565                 570                 575     


Lys Ile Xaa Cys Glu Lys Ile Glu Ala Leu Glu Gln Glu Asn Ser Glu 
            580                 585                 590         


Leu Glu Arg Glu Asn Arg Lys Leu Lys Lys Xaa Leu Asp Ser Phe Lys 
        595                 600                 605             


Asn Leu Xaa Phe Gln Leu Glu Ser Leu Glu Lys Glu Asn Ser Gln Leu 
    610                 615                 620                 


Asp Glu Glu Asn Leu Glu Leu Arg Arg Asn Val Glu Ser Leu Lys Cys 
625                 630                 635                 640 


Ala Ser Met Lys Met Ala Gln Leu Gln Leu Glu Asn Lys Glu Leu Glu 
                645                 650                 655     


Ser Glu Lys Glu Gln Leu Lys Lys Gly Leu Glu Leu Leu Lys Ala Ser 
            660                 665                 670         


Phe Lys Lys Xaa Glu Arg Leu Glu Val Ser Tyr Gln Gly Leu Asp Ile 
        675                 680                 685             


Glu Asn Gln Arg Leu Gln Lys Xaa Leu Glu Asn Ser Asn Lys Lys Ile 
    690                 695                 700                 


Gln Gln Leu Glu Ser Glu Leu Gln Asp Leu Glu Met Glu Asn Gln Xaa 
705                 710                 715                 720 


Leu Gln Lys Asn Leu Glu Glu Leu Lys Ile Ser Ser Lys Arg Leu Glu 
                725                 730                 735     


Gln Leu Glu Arg Lys 
            740     


<210> 5210
<211> 1202
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1173)..(1173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<400> 5210
Gln Leu Glu Lys Asp Lys Lys Gln Leu Glu Lys Glu Asn Lys Arg Leu 
1               5                   10                  15      


Arg Gln Gln Ala Glu Ile Lys Asp Xaa Xaa Leu Glu Glu Asn Asn Val 
            20                  25                  30          


Lys Ile Gly Asn Leu Glu Lys Glu Asn Lys Xaa Leu Ser Lys Glu Ile 
        35                  40                  45              


Gly Ile Tyr Lys Glu Ser Cys Val Arg Leu Lys Glu Leu Glu Lys Glu 
    50                  55                  60                  


Asn Lys Glu Leu Val Lys Arg Ala Xaa Ile Asp Ile Lys Xaa Leu Val 
65                  70                  75                  80  


Xaa Leu Arg Glu Asp Leu Val Ser Glu Lys Leu Lys Xaa Gln Gln Met 
                85                  90                  95      


Asn Asn Asp Leu Glu Lys Leu Xaa His Glu Leu Glu Lys Ile Gly Leu 
            100                 105                 110         


Asn Lys Glu Arg Leu Leu His Asp Glu Gln Ser Xaa Asp Asp Ser Arg 
        115                 120                 125             


Tyr Lys Leu Leu Glu Ser Lys Leu Glu Ser Xaa Leu Lys Lys Ser Leu 
    130                 135                 140                 


Glu Ile Lys Glu Glu Lys Ile Ala Ala Leu Glu Ala Arg Leu Glu Glu 
145                 150                 155                 160 


Ser Xaa Asn Tyr Asn Gln Gln Leu Arg Gln Glu Leu Lys Xaa Val Lys 
                165                 170                 175     


Lys Asn Tyr Glu Ala Leu Lys Gln Arg Gln Asp Glu Glu Arg Met Val 
            180                 185                 190         


Gln Ser Ser Pro Pro Ile Ser Gly Glu Asp Asn Lys Trp Glu Arg Glu 
        195                 200                 205             


Ser Gln Glu Xaa Xaa Arg Glu Leu Leu Lys Val Lys Asp Arg Leu Ile 
    210                 215                 220                 


Glu Val Glu Arg Asn Asn Ala Xaa Leu Gln Ala Glu Lys Gln Ala Leu 
225                 230                 235                 240 


Lys Xaa Gln Leu Lys Gln Leu Glu Xaa Gln Asn Asn Asn Leu Gln Ala 
                245                 250                 255     


Gln Ile Leu Ala Leu Gln Arg Gln Xaa Val Ser Leu Gln Glu Gln Asn 
            260                 265                 270         


Xaa Xaa Leu Gln Xaa Gln Asn Ala Lys Leu Gln Val Glu Asn Ser Xaa 
        275                 280                 285             


Leu Asn Ser Gln Ser Xaa Ser Leu Met Asn Gln Asn Ala Gln Leu Leu 
    290                 295                 300                 


Ile Gln Gln Ser Ser Leu Glu Asn Glu Asn Glu Ser Val Ile Lys Glu 
305                 310                 315                 320 


Arg Glu Asp Leu Lys Ser Leu Tyr Asp Ser Leu Ile Lys Asp His Glu 
                325                 330                 335     


Lys Leu Glu Leu Leu His Glu Arg Gln Ala Ser Glu Tyr Glu Ser Leu 
            340                 345                 350         


Ile Ser Lys His Gly Xaa Leu Lys Ser Ala His Lys Asn Leu Glu Val 
        355                 360                 365             


Glu His Arg Asp Leu Glu Asp Arg Tyr Asn Gln Leu Leu Lys Gln Lys 
    370                 375                 380                 


Gly Gln Leu Glu Asp Leu Glu Lys Met Leu Lys Val Glu Gln Glu Lys 
385                 390                 395                 400 


Met Leu Leu Glu Asn Lys Asn His Glu Xaa Val Ala Ala Glu Tyr Lys 
                405                 410                 415     


Lys Leu Cys Gly Glu Asn Asp Arg Leu Asn His Xaa Tyr Ser Gln Leu 
            420                 425                 430         


Leu Lys Glu Xaa Glu Val Leu Gln Xaa Asp His Lys Asn Leu Lys Ser 
        435                 440                 445             


Leu Leu Asn Asn Ser Lys Leu Glu Gln Xaa Arg Leu Glu Ala Glu Phe 
    450                 455                 460                 


Ser Lys Leu Lys Glu Gln Tyr Gln Gln Leu Asp Ile Xaa Ser Xaa Lys 
465                 470                 475                 480 


Leu Asn Asn Gln Cys Glu Leu Leu Ser Gln Leu Lys Gly Asn Leu Glu 
                485                 490                 495     


Glu Glu Asn Arg His Leu Leu Asp Gln Ile Gln Xaa Leu Met Leu Gln 
            500                 505                 510         


Asn Arg Xaa Leu Leu Glu Gln Asn Met Glu Ser Lys Asp Leu Phe His 
        515                 520                 525             


Val Glu Gln Arg Gln Tyr Ile Asp Lys Leu Asn Glu Leu Arg Arg Gln 
    530                 535                 540                 


Lys Glu Lys Leu Glu Glu Lys Ile Met Asp Gln Tyr Lys Phe Tyr Asp 
545                 550                 555                 560 


Pro Ser Pro Pro Arg Arg Arg Gly Asn Trp Ile Xaa Leu Lys Met Arg 
                565                 570                 575     


Lys Leu Ile Lys Ser Lys Lys Asp Ile Asn Arg Glu Arg Gln Lys Ser 
            580                 585                 590         


Leu Xaa Leu Xaa Pro Xaa Arg Ser Asp Ser Ser Glu Gly Phe Leu Gln 
        595                 600                 605             


Leu Pro His Gln Asp Ser Gln Asp Ser Ser Ser Val Gly Ser Asn Ser 
    610                 615                 620                 


Leu Glu Asp Gly Gln Xaa Leu Gly Xaa Lys Lys Ser Ser Met Val Ala 
625                 630                 635                 640 


Leu Lys Arg Leu Pro Phe Leu Arg Asn Arg Pro Lys Asp Lys Asp Lys 
                645                 650                 655     


Met Lys Ala Cys Tyr Arg Arg Ser Met Ser Met Asn Asp Leu Val Gln 
            660                 665                 670         


Ser Met Val Leu Ala Gly Gln Trp Xaa Gly Ser Xaa Glu Asn Leu Glu 
        675                 680                 685             


Val Pro Asp Asp Ile Ser Xaa Gly Lys Arg Arg Lys Glu Leu Gly Ala 
    690                 695                 700                 


Met Ala Phe Ser Xaa Xaa Ala Ile Asn Phe Ser Xaa Val Asn Ser Ser 
705                 710                 715                 720 


Ala Gly Phe Arg Ser Lys Gln Leu Val Asn Asn Lys Asp Xaa Xaa Ser 
                725                 730                 735     


Phe Glu Asp Ile Ser Pro Gln Gly Val Ser Asp Asp Ser Ser Xaa Gly 
            740                 745                 750         


Ser Arg Val His Ala Ser Arg Pro Ala Ser Leu Asp Ser Gly Arg Xaa 
        755                 760                 765             


Ser Xaa Ser Asn Ser Asn Asn Asn Ala Ser Leu His Glu Val Lys Ala 
    770                 775                 780                 


Gly Ala Val Asn Asn Gln Ser Arg Pro Gln Ser His Ser Ser Gly Glu 
785                 790                 795                 800 


Phe Ser Leu Leu His Asp His Glu Ala Trp Ser Ser Ser Gly Ser Ser 
                805                 810                 815     


Pro Ile Gln Tyr Leu Lys Arg Gln Xaa Arg Ser Ser Pro Val Leu Gln 
            820                 825                 830         


His Lys Ile Ser Glu Xaa Leu Glu Ser Arg His His Lys Ile Lys Xaa 
        835                 840                 845             


Gly Ser Pro Gly Ser Glu Val Val Xaa Leu Gln Gln Phe Leu Glu Glu 
    850                 855                 860                 


Ser Asn Lys Leu Xaa Ser Val Gln Ile Lys Ser Ser Ser Gln Glu Asn 
865                 870                 875                 880 


Leu Leu Asp Glu Val Met Lys Ser Leu Ser Val Ser Ser Asp Phe Leu 
                885                 890                 895     


Gly Lys Asp Lys Pro Val Ser Cys Gly Leu Ala Arg Ser Val Ser Gly 
            900                 905                 910         


Lys Xaa Pro Gly Asp Phe Tyr Asp Arg Arg Xaa Xaa Lys Pro Glu Phe 
        915                 920                 925             


Leu Arg Pro Gly Pro Arg Lys Xaa Glu Asp Xaa Tyr Phe Ile Ser Ser 
    930                 935                 940                 


Ala Gly Lys Pro Xaa Pro Gly Xaa Gln Gly Lys Ile Lys Leu Val Lys 
945                 950                 955                 960 


Glu Ser Ser Leu Ser Arg Gln Ser Lys Asp Ser Asn Pro Tyr Ala Xaa 
                965                 970                 975     


Leu Pro Arg Ala Ser Ser Val Ile Ser Xaa Ala Glu Gly Xaa Xaa Arg 
            980                 985                 990         


Arg Xaa Ser Ile His Asp Phe Leu  Xaa Lys Asp Ser Arg  Leu Pro Ile 
        995                 1000                 1005             


Ser Val  Asp Ser Pro Pro Ala  Ala Ala Asp Ser Asn  Xaa Xaa Ala 
    1010                 1015                 1020             


Ala Ser  Ser Glu Tyr His Leu  His Gln Trp Ser Ser  His Ile Leu 
    1025                 1030                 1035             


Asp Ile  Pro Xaa His Xaa Ile  Gly Ser Cys Ala Gln  Asn Asp Leu 
    1040                 1045                 1050             


Ala Ile  Asp Met Pro Glu Pro  Leu Tyr Ala Gln Ala  Arg Asn Ser 
    1055                 1060                 1065             


Arg Xaa  Gly Arg Ser His Phe  Leu Asn Gln Xaa Phe  Ala Xaa Ile 
    1070                 1075                 1080             


Arg Met  Pro Ser Asp Ala Phe  Gly Met Leu Ala Lys  Asp Ser Ile 
    1085                 1090                 1095             


Gly Pro  Phe Xaa Val Ala His  Ser Ser Gln Pro Phe  Leu Ser Leu 
    1100                 1105                 1110             


Asn Xaa  Glu Leu Val Ser Asn  Ile Ser Gly Leu Pro  Pro Arg Pro 
    1115                 1120                 1125             


Val Ile  Arg Ile Xaa Asp Gln  Ala Ser Ala Ser Leu  Asp Lys Pro 
    1130                 1135                 1140             


Ala Gln  Lys Glu Asn Glu Gln  Phe Ser Asp His Gln  Asn Pro Ser 
    1145                 1150                 1155             


Asn Ser  Asn Leu Gln Phe Ser  Ile Asn Ser Asn Asn  Leu Val Xaa 
    1160                 1165                 1170             


Ser Ala  Cys Leu Tyr Pro Asp  Asp Xaa Glu Ala Ala  Leu Leu Val 
    1175                 1180                 1185             


Ser Glu  Asp Asn Gln Xaa Val  Trp Tyr Glu Tyr Gly  Cys Ile 
    1190                 1195                 1200         


<210> 5211
<211> 374
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(350)
<223> Selenocysteine

<400> 5211
Xaa Ile Met Asp Gln Tyr Lys Phe Tyr Asp Pro Ser Pro Pro Arg Arg 
1               5                   10                  15      


Arg Gly Asn Trp Ile Xaa Leu Lys Met Arg Lys Leu Ile Lys Ser Lys 
            20                  25                  30          


Lys Asp Ile Asn Arg Glu Arg Gln Lys Ser Leu Xaa Leu Xaa Pro Xaa 
        35                  40                  45              


Arg Ser Asp Ser Ser Glu Gly Phe Leu Gln Leu Pro His Gln Asp Ser 
    50                  55                  60                  


Gln Asp Ser Ser Ser Val Gly Ser Asn Ser Leu Glu Asp Gly Gln Xaa 
65                  70                  75                  80  


Leu Gly Xaa Lys Lys Ser Ser Asn Xaa Xaa Ser Phe Glu Asp Ile Ser 
                85                  90                  95      


Pro Gln Gly Val Ser Asp Asp Ser Ser Xaa Gly Ser Arg Val His Ala 
            100                 105                 110         


Gly Ala Val Asn Asn Gln Ser Arg Pro Gln Ser His Ser Ser Gly Glu 
        115                 120                 125             


Phe Ser Leu Leu His Asp His Glu Ala Trp Ser Ser Ser Gly Ser Ser 
    130                 135                 140                 


Pro Ile Gln Tyr Leu Lys Arg Gln Xaa Arg Ser Ser Pro Val Leu Gln 
145                 150                 155                 160 


His Lys Ile Ser Glu Xaa Leu Glu Ser Arg His His Lys Ile Lys Xaa 
                165                 170                 175     


Gly Ser Pro Gly Ser Glu Val Val Xaa Leu Gln Gln Phe Leu Glu Glu 
            180                 185                 190         


Ser Asn Lys Leu Xaa Ser Val Gln Ile Lys Ser Ser Ser Gln Glu Asn 
        195                 200                 205             


Leu Leu Asp Glu Val Met Lys Ser Leu Ser Val Ser Ser Asp Phe Leu 
    210                 215                 220                 


Gly Lys Asp Lys Pro Val Ser Cys Gly Leu Ala Arg Ser Val Ser Gly 
225                 230                 235                 240 


Lys Xaa Pro Gly Asp Phe Tyr Asp Arg Arg Xaa Xaa Lys Pro Glu Phe 
                245                 250                 255     


Leu Arg Pro Gly Pro Arg Lys Xaa Glu Asp Xaa Tyr Phe Ile Ser Ser 
            260                 265                 270         


Ala Gly Lys Pro Xaa Pro Gly Xaa Gln Gly Lys Ile Lys Leu Val Lys 
        275                 280                 285             


Glu Ser Ser Leu Ser Arg Gln Ser Lys Asp Ser Asn Pro Tyr Ala Xaa 
    290                 295                 300                 


Leu Pro Arg Ala Ser Ser Val Ile Ser Xaa Ala Glu Gly Xaa Xaa Arg 
305                 310                 315                 320 


Arg Xaa Ser Ile His Asp Phe Leu Xaa Lys Asp Ser Arg Leu Pro Ile 
                325                 330                 335     


Ser Val Asp Ser Pro Pro Ala Ala Ala Asp Ser Asn Xaa Xaa Ala Ala 
            340                 345                 350         


Ser Asn Val Asp Lys Val Gln Glu Ser Arg Asn Ser Lys Ser Arg Ser 
        355                 360                 365             


Arg Glu Gln Gln Ser Ser 
    370                 


<210> 5212
<211> 737
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<400> 5212
Xaa Lys Lys Ser Leu Glu Ile Lys Glu Glu Lys Ile Ala Ala Leu Glu 
1               5                   10                  15      


Ala Arg Leu Glu Glu Ser Xaa Asn Tyr Asn Gln Gln Leu Arg Gln Glu 
            20                  25                  30          


Leu Lys Xaa Asn Ala Xaa Leu Gln Ala Glu Lys Gln Ala Leu Lys Xaa 
        35                  40                  45              


Gln Leu Lys Gln Leu Glu Xaa Gln Asn Asn Asn Leu Gln Ala Gln Ile 
    50                  55                  60                  


Leu Ala Leu Gln Arg Gln Xaa Val Ser Leu Gln Glu Gln Asn Xaa Xaa 
65                  70                  75                  80  


Leu Gln Xaa Gln Asn Ala Lys Leu Gln Val Glu Asn Ser Xaa Leu Asn 
                85                  90                  95      


Ser Gln Ser Xaa Ser Leu Met Asn Gln Asn Ala Gln Leu Leu Ile Gln 
            100                 105                 110         


Gln Ser Ser Leu Glu Asn Glu Asn Glu Ser Val Ile Lys Glu Arg Glu 
        115                 120                 125             


Asp Leu Lys Ser Leu Tyr Asp Ser Leu Ile Lys Asp His Glu Lys Leu 
    130                 135                 140                 


Glu Leu Leu His Glu Arg Gln Ala Ser Glu Tyr Glu Ser Leu Ile Ser 
145                 150                 155                 160 


Lys His Gly Xaa Leu Lys Ser Ala His Lys Asn Leu Glu Val Glu His 
                165                 170                 175     


Arg Asp Leu Glu Asp Arg Tyr Asn Gln Leu Leu Lys Gln Lys Gly Gln 
            180                 185                 190         


Leu Glu Asp Leu Glu Lys Met Leu Lys Val Glu Gln Glu Lys Met Leu 
        195                 200                 205             


Leu Glu Asn Lys Asn His Glu Xaa Val Ala Ala Glu Tyr Lys Lys Leu 
    210                 215                 220                 


Cys Gly Glu Asn Asp Arg Leu Asn His Xaa Tyr Ser Gln Leu Leu Lys 
225                 230                 235                 240 


Glu Xaa Glu Val Leu Gln Xaa Asp His Lys Asn Leu Lys Ser Leu Leu 
                245                 250                 255     


Asn Asn Ser Lys Leu Glu Gln Xaa Arg Leu Glu Ala Glu Phe Ser Lys 
            260                 265                 270         


Leu Lys Glu Gln Tyr Gln Gln Leu Asp Ile Xaa Ser Xaa Lys Leu Asn 
        275                 280                 285             


Asn Gln Cys Glu Leu Leu Ser Gln Leu Lys Gly Asn Leu Glu Glu Glu 
    290                 295                 300                 


Asn Arg His Leu Leu Asp Gln Ile Gln Xaa Leu Met Leu Gln Asn Arg 
305                 310                 315                 320 


Xaa Leu Leu Glu Gln Asn Met Glu Ser Lys Asp Leu Phe His Val Glu 
                325                 330                 335     


Gln Arg Gln Tyr Ile Asp Lys Leu Asn Glu Leu Arg Arg Gln Lys Glu 
            340                 345                 350         


Lys Leu Glu Glu Lys Ile Met Asp Gln Tyr Lys Phe Tyr Asp Pro Ser 
        355                 360                 365             


Pro Pro Arg Arg Arg Gly Asn Trp Ile Xaa Leu Lys Met Arg Lys Leu 
    370                 375                 380                 


Ile Lys Ser Lys Lys Asp Ile Asn Arg Glu Arg Gln Lys Ser Leu Xaa 
385                 390                 395                 400 


Leu Xaa Pro Xaa Arg Ser Asp Ser Ser Glu Gly Phe Leu Gln Leu Pro 
                405                 410                 415     


His Gln Asp Ser Gln Asp Ser Ser Ser Val Gly Ser Asn Ser Leu Glu 
            420                 425                 430         


Asp Gly Gln Xaa Leu Gly Xaa Lys Lys Ser Ser Xaa Met Asn Asp Leu 
        435                 440                 445             


Val Gln Ser Met Val Leu Ala Gly Gln Trp Xaa Gly Ser Xaa Glu Asn 
    450                 455                 460                 


Leu Glu Val Pro Asp Asp Ile Ser Xaa Gly Lys Arg Arg Lys Glu Leu 
465                 470                 475                 480 


Gly Ala Met Ala Phe Ser Xaa Xaa Ala Ile Asn Phe Ser Xaa Val Asn 
                485                 490                 495     


Ser Ser Ala Gly Phe Arg Ser Lys Gln Leu Val Asn Asn Lys Asp Xaa 
            500                 505                 510         


Xaa Ser Phe Glu Asp Ile Ser Pro Gln Gly Val Ser Asp Asp Ser Ser 
        515                 520                 525             


Xaa Gly Ser Arg Val His Ala Ser Arg Pro Ala Ser Leu Asp Ser Gly 
    530                 535                 540                 


Arg Xaa Ser Xaa Ser Asn Ser Asn Asn Asn Ala Ser Leu His Glu Val 
545                 550                 555                 560 


Lys Ala Gly Ala Val Asn Asn Gln Ser Arg Pro Gln Ser His Ser Ser 
                565                 570                 575     


Gly Glu Phe Ser Leu Leu His Asp His Glu Ala Trp Ser Ser Ser Gly 
            580                 585                 590         


Ser Ser Pro Ile Gln Tyr Leu Lys Arg Gln Xaa Arg Ser Ser Pro Val 
        595                 600                 605             


Leu Gln His Lys Ile Ser Glu Xaa Leu Glu Ser Arg His His Lys Ile 
    610                 615                 620                 


Lys Xaa Gly Ser Pro Gly Ser Glu Val Val Xaa Leu Gln Gln Phe Leu 
625                 630                 635                 640 


Glu Glu Ser Asn Lys Leu Xaa Ser Val Gln Ile Lys Ser Ser Ser Gln 
                645                 650                 655     


Glu Asn Leu Leu Asp Glu Val Met Lys Ser Leu Ser Val Ser Ser Asp 
            660                 665                 670         


Phe Leu Gly Lys Asp Lys Pro Val Ser Cys Gly Leu Ala Arg Ser Val 
        675                 680                 685             


Ser Gly Lys Xaa Pro Gly Asp Phe Tyr Asp Arg Arg Xaa Xaa Lys Pro 
    690                 695                 700                 


Glu Phe Leu Arg Pro Gly Pro Arg Lys Xaa Glu Asp Xaa Tyr Phe Ile 
705                 710                 715                 720 


Ser Ser Ala Gly Lys Pro Xaa Pro Gly Xaa Gln Gly Lys Ile Lys Leu 
                725                 730                 735     


Val 
    


<210> 5213
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<400> 5213
Met Asp Val Xaa Val Ser Glu Leu Leu Glu Leu Phe Leu Gln Ser Pro 
1               5                   10                  15      


Leu Val Xaa Trp Val Lys Xaa Phe Gly Pro Phe Gly Ser Gly Ser Gln 
            20                  25                  30          


Asp Asn Leu Xaa Met Tyr Met Asp Leu Val Asp Gly Ile Phe Leu Asn 
        35                  40                  45              


Gln Ile Met Leu Gln Ile Asp Pro Arg Pro Xaa Asn Gln Arg Ile Asn 
    50                  55                  60                  


Lys His Val Asn Asn Asp Val Asn Leu Arg Ile Gln Asn Leu Xaa Ile 
65                  70                  75                  80  


Leu Val Arg Asn Ile Lys Xaa Tyr Tyr Gln Asp Arg Pro Phe Phe Arg 
                85                  90                  95      


<210> 5214
<211> 2028
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1161)..(1161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1176)..(1176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1197)..(1197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1243)..(1243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1315)..(1315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1429)..(1429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1460)..(1460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1500)..(1500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1504)..(1504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1522)..(1522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1525)..(1527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1533)..(1533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1579)..(1579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1615)..(1615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1622)..(1622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1651)..(1651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1671)..(1671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1685)..(1685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1688)..(1688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1726)..(1726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1732)..(1732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1739)..(1739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1758)..(1758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1840)..(1840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1844)..(1844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1861)..(1861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1883)..(1883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1904)..(1904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1910)..(1910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1939)..(1939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1952)..(1952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1954)..(1954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2020)..(2020)
<223> Selenocysteine

<400> 5214
Met Asp Val Xaa Val Ser Glu Leu Leu Glu Leu Phe Leu Gln Ser Pro 
1               5                   10                  15      


Leu Val Xaa Trp Val Lys Xaa Phe Gly Pro Phe Gly Ser Gly Ser Gln 
            20                  25                  30          


Asp Asn Leu Xaa Met Tyr Met Asp Leu Val Asp Gly Ile Phe Leu Asn 
        35                  40                  45              


Gln Ile Met Leu Gln Ile Asp Pro Arg Pro Xaa Asn Gln Arg Ile Asn 
    50                  55                  60                  


Lys His Val Asn Asn Asp Val Asn Leu Arg Ile Gln Asn Leu Xaa Ile 
65                  70                  75                  80  


Leu Val Arg Asn Ile Lys Xaa Tyr Tyr Gln Glu Val Leu Gln Gln Leu 
                85                  90                  95      


Ile Val Met Asn Leu Pro Asn Val Leu Met Ile Gly Arg Asp Pro Leu 
            100                 105                 110         


Ser Gly Lys Ser Met Glu Glu Ile Lys Lys Val Leu Leu Leu Val Leu 
        115                 120                 125             


Gly Cys Ala Val Gln Cys Glu Arg Lys Glu Glu Phe Ile Glu Arg Ile 
    130                 135                 140                 


Lys Gln Leu Asp Ile Glu Xaa Gln Ala Gly Ile Val Ala His Ile Gln 
145                 150                 155                 160 


Glu Val Xaa His Asn Gln Glu Asn Val Phe Asp Leu Gln Trp Leu Glu 
                165                 170                 175     


Leu Pro Asp Val Ala Pro Glu Glu Leu Glu Ala Leu Ser Arg Ser Met 
            180                 185                 190         


Val Leu His Leu Arg Arg Leu Ile Asp Gln Arg Asp Glu Cys Xaa Glu 
        195                 200                 205             


Leu Ile Val Asp Leu Xaa Gln Glu Arg Asp Tyr Leu Gln Ala Gln His 
    210                 215                 220                 


Pro Pro Ser Pro Ile Lys Ser Ser Ser Ala Asp Ser Xaa Pro Ser Pro 
225                 230                 235                 240 


Xaa Ser Ser Leu Ser Ser Glu Asp Lys Gln His Leu Ala Val Glu Leu 
                245                 250                 255     


Ala Asp Xaa Lys Ala Arg Leu Arg Arg Val Arg Gln Glu Leu Glu Asp 
            260                 265                 270         


Lys Xaa Glu Gln Leu Val Asp Xaa Arg His Glu Val Asp Gln Leu Val 
        275                 280                 285             


Leu Glu Leu Gln Lys Val Lys Gln Glu Asn Ile Gln Leu Ala Ala Asp 
    290                 295                 300                 


Ala Arg Ser Ala Arg Ala Tyr Arg Asp Glu Leu Asp Ser Leu Arg Glu 
305                 310                 315                 320 


Lys Ala Asn Arg Val Glu Arg Leu Glu Leu Glu Leu Xaa Arg Cys Lys 
                325                 330                 335     


Glu Lys Leu His Asp Val Asp Phe Tyr Lys Ala Arg Met Glu Glu Leu 
            340                 345                 350         


Arg Glu Asp Asn Ile Ile Leu Ile Glu Xaa Lys Ala Met Leu Glu Glu 
        355                 360                 365             


Gln Leu Xaa Ala Ala Arg Ala Arg Gly Asp Lys Val His Glu Leu Glu 
    370                 375                 380                 


Lys Glu Asn Leu Gln Leu Lys Ser Lys Leu His Asp Leu Glu Leu Asp 
385                 390                 395                 400 


Arg Asp Xaa Asp Lys Lys Arg Ile Glu Glu Leu Leu Glu Glu Asn Met 
                405                 410                 415     


Val Leu Glu Ile Ala Gln Lys Gln Ser Met Asn Glu Ser Ala His Leu 
            420                 425                 430         


Gly Trp Glu Leu Glu Gln Leu Ser Lys Asn Ala Asp Leu Ser Asp Ala 
        435                 440                 445             


Ser Arg Lys Ser Phe Val Phe Glu Leu Asn Glu Cys Ala Ser Ser Arg 
    450                 455                 460                 


Ile Leu Lys Leu Glu Lys Glu Asn Gln Ser Leu Gln Ser Xaa Ile Gln 
465                 470                 475                 480 


Gly Leu Arg Asp Ala Ser Leu Val Leu Glu Glu Ser Gly Leu Lys Cys 
                485                 490                 495     


Gly Glu Leu Glu Lys Glu Asn His Gln Leu Ser Lys Lys Ile Glu Lys 
            500                 505                 510         


Leu Gln Xaa Gln Leu Glu Arg Glu Lys Gln Ser Asn Gln Asp Leu Glu 
        515                 520                 525             


Xaa Leu Ser Glu Glu Leu Ile Arg Glu Lys Glu Gln Leu Gln Ser Asp 
    530                 535                 540                 


Met Glu Xaa Leu Lys Ala Asp Lys Ala Arg Gln Ile Lys Asp Leu Glu 
545                 550                 555                 560 


Gln Glu Lys Asp His Leu Asn Arg Ala Met Trp Ser Leu Arg Glu Arg 
                565                 570                 575     


Ser Gln Val Ser Ser Glu Ala Arg Met Lys Asp Val Glu Lys Glu Asn 
            580                 585                 590         


Lys Ala Leu His Gln Xaa Val Xaa Glu Ala Asn Gly Lys Leu Ser Gln 
        595                 600                 605             


Leu Glu Phe Glu Lys Arg Gln Leu His Arg Asp Leu Glu Gln Ala Lys 
    610                 615                 620                 


Glu Lys Gly Glu Arg Ala Glu Lys Leu Glu Arg Glu Leu Gln Arg Leu 
625                 630                 635                 640 


Gln Glu Glu Asn Gly Arg Leu Ala Arg Lys Val Xaa Ser Leu Glu Xaa 
                645                 650                 655     


Ala Xaa Glu Lys Val Glu Ala Leu Glu His Glu Ser Gln Gly Leu Gln 
            660                 665                 670         


Leu Glu Asn Arg Xaa Leu Arg Lys Ser Leu Asp Xaa Leu Gln Asn Val 
        675                 680                 685             


Ser Leu Gln Leu Glu Gly Leu Glu Arg Asp Asn Lys Gln Leu Asp Ala 
    690                 695                 700                 


Glu Asn Leu Glu Leu Arg Arg Leu Val Glu Xaa Met Arg Phe Xaa Ser 
705                 710                 715                 720 


Xaa Lys Leu Ala Gln Met Glu Arg Glu Asn Gln Gln Leu Glu Arg Glu 
                725                 730                 735     


Lys Glu Glu Leu Arg Lys Asn Val Asp Leu Leu Lys Ala Leu Gly Lys 
            740                 745                 750         


Lys Ser Glu Arg Leu Glu Leu Ser Tyr Gln Ser Val Ser Ala Glu Asn 
        755                 760                 765             


Leu Arg Leu Gln Gln Ser Leu Glu Ser Ser Ser His Lys Xaa Gln Xaa 
    770                 775                 780                 


Leu Glu Ser Glu Leu Gly Glu Leu Glu Ala Glu Arg Gln Ala Leu Arg 
785                 790                 795                 800 


Arg Asp Leu Glu Ala Leu Arg Leu Ala Asn Ala Gln Leu Glu Gly Ala 
                805                 810                 815     


Glu Lys Asp Arg Lys Ala Leu Glu Gln Glu Val Ala Gln Leu Glu Lys 
            820                 825                 830         


Asp Lys Lys Leu Leu Glu Lys Glu Ala Lys Arg Leu Trp Gln Gln Val 
        835                 840                 845             


Glu Leu Lys Asp Ala Val Leu Asp Asp Ser Xaa Ala Lys Leu Ser Ala 
    850                 855                 860                 


Val Glu Lys Glu Ser Arg Ala Leu Asp Lys Glu Leu Ala Arg Cys Arg 
865                 870                 875                 880 


Asp Ala Ala Gly Lys Leu Lys Glu Leu Glu Lys Asp Asn Arg Asp Leu 
                885                 890                 895     


Xaa Lys Gln Val Xaa Val His Ala Arg Xaa Leu Xaa Xaa Leu Arg Glu 
            900                 905                 910         


Asp Leu Val Leu Glu Lys Leu Lys Ser Gln Gln Leu Ser Ser Glu Leu 
        915                 920                 925             


Asp Lys Leu Ser Gln Glu Leu Glu Lys Val Gly Leu Asn Arg Glu Leu 
    930                 935                 940                 


Leu Leu Gln Glu Asp Asp Ser Gly Ser Asp Xaa Lys Tyr Lys Ile Leu 
945                 950                 955                 960 


Glu Gly Arg Asn Glu Ser Ala Leu Lys Xaa Xaa Leu Ala Met Lys Glu 
                965                 970                 975     


Glu Lys Ile Val Leu Leu Glu Ala Gln Met Glu Glu Lys Ala Ser Leu 
            980                 985                 990         


Asn Arg Gln Leu Glu Ser Glu Leu  Gln Met Leu Lys Lys  Glu Cys Glu 
        995                 1000                 1005             


Xaa Leu  Arg Gln Asn Gln Gly  Glu Gly Gln His Leu  Gln Asn Ser 
    1010                 1015                 1020             


Phe Lys  His Pro Ala Gly Lys  Xaa Ala Ala Ser His  Gln Gly Lys 
    1025                 1030                 1035             


Glu Ala  Trp Gly Pro Gly His  Lys Glu Ala Xaa Met  Glu Leu Leu 
    1040                 1045                 1050             


Arg Val  Lys Asp Arg Ala Ile  Glu Leu Glu Arg Asn  Asn Ala Ala 
    1055                 1060                 1065             


Leu Gln  Ala Glu Lys Gln Leu  Leu Lys Glu Gln Leu  Gln His Leu 
    1070                 1075                 1080             


Glu Xaa  Gln Asn Val Xaa Phe  Ser Ser Gln Ile Leu  Xaa Leu Gln 
    1085                 1090                 1095             


Lys Gln  Ser Ala Phe Leu Gln  Glu His Asn Xaa Xaa  Leu Gln Xaa 
    1100                 1105                 1110             


Gln Xaa  Ala Lys Leu Gln Val  Glu Asn Ser Xaa Leu  Ser Ser Gln 
    1115                 1120                 1125             


Ser Ala  Ala Leu Xaa Ala Gln  Tyr Xaa Leu Leu Gln  Asn His His 
    1130                 1135                 1140             


Xaa Ala  Lys Glu Xaa Glu Asn  Glu Ser Leu Gln Arg  Gln Gln Glu 
    1145                 1150                 1155             


Gln Leu  Xaa Ala Ala Tyr Glu  Ala Leu Leu Gln Asp  His Glu His 
    1160                 1165                 1170             


Leu Gly  Xaa Leu His Glu Arg  Gln Ser Ala Glu Tyr  Glu Ala Leu 
    1175                 1180                 1185             


Ile Arg  Gln His Ser Cys Leu  Lys Xaa Leu His Arg  Asn Leu Glu 
    1190                 1195                 1200             


Leu Glu  His Lys Glu Leu Gly  Glu Arg His Gly Asp  Met Leu Lys 
    1205                 1210                 1215             


Arg Lys  Ala Glu Leu Glu Glu  Arg Glu Lys Val Leu  Xaa Xaa Glu 
    1220                 1225                 1230             


Arg Glu  Ala Leu Gln Gln Glu  Gln Arg Xaa Asn Ala  Leu Ala Met 
    1235                 1240                 1245             


Gly Glu  Asn Gln Arg Leu Arg  Gly Glu Leu Asp Arg  Val Asn Phe 
    1250                 1255                 1260             


Leu His  His Gln Leu Lys Gly  Glu Tyr Glu Glu Leu  His Ala His 
    1265                 1270                 1275             


Xaa Lys  Glu Leu Lys Xaa Ser  Leu Asn Asn Ala Gln  Leu Glu Leu 
    1280                 1285                 1290             


Asn Arg  Trp Gln Ala Arg Phe  Asp Glu Leu Lys Glu  Gln His Gln 
    1295                 1300                 1305             


Xaa Met  Asp Ile Ser Leu Xaa  Lys Leu Asp Asn His  Cys Glu Leu 
    1310                 1315                 1320             


Leu Ser  Arg Leu Lys Gly Asn  Leu Glu Glu Glu Asn  His His Leu 
    1325                 1330                 1335             


Leu Ser  Gln Ile Gln Leu Leu  Ser Gln Gln Asn Gln  Met Leu Leu 
    1340                 1345                 1350             


Glu Gln  Asn Met Glu Asn Lys  Glu Gln Tyr His Glu  Glu Gln Lys 
    1355                 1360                 1365             


Gln Tyr  Ile Asp Lys Leu Asn  Ala Leu Arg Arg His  Lys Glu Lys 
    1370                 1375                 1380             


Leu Glu  Glu Lys Ile Met Asp  Gln Tyr Lys Phe Tyr  Asp Pro Pro 
    1385                 1390                 1395             


Pro Lys  Lys Lys Asn His Trp  Ile Gly Ala Lys Ala  Leu Val Lys 
    1400                 1405                 1410             


Leu Ile  Lys Pro Lys Lys Glu  Gly Ser Arg Glu Arg  Leu Lys Ser 
    1415                 1420                 1425             


Xaa Val  Asp Ser Pro Pro Trp  Gln Leu Glu Ser Ser  Asp Pro Ala 
    1430                 1435                 1440             


Ser Pro  Ala Ala Ser Gln Pro  Leu Arg Ser Gln Ala  Glu Asn Pro 
    1445                 1450                 1455             


Asp Xaa  Pro Ala Leu Gly Ser  Asn Cys Ala Glu Glu  Arg Asp Ala 
    1460                 1465                 1470             


His Asn  Gly Ser Val Gly Lys  Gly Pro Gly Asp Leu  Lys Pro Lys 
    1475                 1480                 1485             


Arg Gly  Ser Pro His Arg Gly  Ser Leu Asp Arg Xaa  Asp Ala Ser 
    1490                 1495                 1500             


Xaa Asp  Leu Ala Met Arg Ser  Trp Pro Ser Glu Leu  Gly Ser Arg 
    1505                 1510                 1515             


Xaa Cys  Ser Xaa Ser Ala Xaa  Xaa Xaa Ala Pro Ser  Asn Ser Xaa 
    1520                 1525                 1530             


Pro Ile  Ala Arg His Pro Gly  Arg Xaa Lys Gly Tyr  Asn Ser Asp 
    1535                 1540                 1545             


Asp Asn  Leu Cys Glu Pro Ser  Leu Glu Phe Glu Val  Pro Asn His 
    1550                 1555                 1560             


Arg Gln  Tyr Val Ser Arg Pro  Ser Ser Leu Glu Ser  Ser Arg Asn 
    1565                 1570                 1575             


Xaa Ser  Ser Asn Ser Ser Pro  Leu Asn Leu Lys Gly  Ser Ser Glu 
    1580                 1585                 1590             


Gln Leu  His Gly Arg Ser Glu  Ser Phe Ser Ser Glu  Asp Leu Ile 
    1595                 1600                 1605             


Pro Ser  Arg Asp Leu Ala Xaa  Leu Pro Arg Glu Ala  Ser Xaa Pro 
    1610                 1615                 1620             


Gly Arg  Asn Ala Leu Gly Arg  His Glu Tyr Pro Leu  Pro Arg Asn 
    1625                 1630                 1635             


Gly Pro  Leu Pro Gln Glu Gly  Ala Gln Lys Arg Gly  Xaa Ala Pro 
    1640                 1645                 1650             


Pro Tyr  Val Gly Val Arg Pro  Cys Ser Ala Ser Pro  Ser Ser Glu 
    1655                 1660                 1665             


Met Val  Xaa Leu Glu Glu Phe  Leu Glu Glu Ser Asn  Arg Ser Ser 
    1670                 1675                 1680             


Pro Xaa  His Asp Xaa Pro Ser  Cys Arg Asp Asp Leu  Leu Ser Asp 
    1685                 1690                 1695             


Tyr Phe  Arg Lys Ala Ser Asp  Pro Pro Ala Ile Gly  Gly Gln Pro 
    1700                 1705                 1710             


Gly Pro  Pro Ala Lys Lys Glu  Gly Ala Lys Met Pro  Xaa Asn Phe 
    1715                 1720                 1725             


Val Ala  Pro Xaa Val Lys Met  Ala Ala Pro Xaa Ser  Glu Gly Arg 
    1730                 1735                 1740             


Pro Leu  Lys Pro Gly Gln Tyr  Val Lys Pro Asn Phe  Arg Leu Xaa 
    1745                 1750                 1755             


Glu Ala  Glu Ala Pro Pro Ser  Val Ala Pro Arg Gln  Ala Gln Pro 
    1760                 1765                 1770             


Pro Gln  Ser Leu Ser Leu Gly  Arg Pro Arg Gln Ala  Pro Val Pro 
    1775                 1780                 1785             


Pro Ala  Ser His Ala Pro Ala  Ser Arg Ser Ala Ser  Leu Ser Arg 
    1790                 1795                 1800             


Ala Phe  Ser Leu Ala Ser Ala  Asp Leu Leu Arg Ala  Ser Gly Pro 
    1805                 1810                 1815             


Glu Ala  Cys Lys Gln Glu Ser  Pro Gln Lys Leu Gly  Ala Pro Glu 
    1820                 1825                 1830             


Ala Leu  Gly Gly Arg Glu Xaa  Gly Ser His Xaa Leu  Gln Ser Pro 
    1835                 1840                 1845             


Ala Pro  Pro Ser Ser His Ser  Leu Ala Arg Glu Arg  Xaa Pro Leu 
    1850                 1855                 1860             


Val Gly  Lys Ala Gly Ser Ser  Cys Gln Gly Pro Gly  Pro Arg Ser 
    1865                 1870                 1875             


Arg Pro  Leu Asp Xaa Arg Arg  Phe Ser Leu Ala Pro  Pro Lys Glu 
    1880                 1885                 1890             


Glu Arg  Leu Ala Pro Leu His  Gln Ser Ala Xaa Ala  Pro Ala Ile 
    1895                 1900                 1905             


Ala Xaa  Ala Gly Ala Gly Ala  Ala Ala Ala Gly Ser  Gly Ser Asn 
    1910                 1915                 1920             


Ser Gln  Leu Leu His Phe Ser  Pro Ala Ala Ala Pro  Ala Ala Arg 
    1925                 1930                 1935             


Xaa Lys  Pro Lys Ala Pro Pro  Arg Ser Gly Glu Val  Ala Xaa Ile 
    1940                 1945                 1950             


Xaa Pro  Val Arg Ala Gly Leu  Ser Leu Ser Glu Gly  Asp Gly Val 
    1955                 1960                 1965             


Pro Gly  Gln Gly Cys Ser Glu  Gly Leu Pro Ala Lys  Ser Pro Gly 
    1970                 1975                 1980             


Arg Ser  Pro Asp Leu Ala Pro  His Leu Gly Arg Ala  Leu Glu Asp 
    1985                 1990                 1995             


Cys Ser  Arg Gly Ser Val Ser  Lys Ser Ser Pro Ala  Ser Pro Glu 
    2000                 2005                 2010             


Pro Gly  Gly Asp Pro Gln Xaa  Val Trp Tyr Glu Tyr  Gly Cys Val 
    2015                 2020                 2025             


<210> 5215
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<400> 5215
Met Gly Gly Ala Glu Trp Glu Ser Glu Gln Xaa Gly Val Lys Xaa Phe 
1               5                   10                  15      


Gly Pro Phe Gly Ser Gly Ser Gln Asp Asn Leu Xaa Met Tyr Met Asp 
            20                  25                  30          


Leu Val Asp Gly Ile Phe Leu Asn Gln Ile Met Leu Gln Ile Asp Pro 
        35                  40                  45              


Arg Pro Xaa Asn Gln Arg Ile Asn Lys His Val Asn Asn Asp Val Asn 
    50                  55                  60                  


Leu Arg Ile Gln Asn Leu Xaa Ile Leu Val Arg Asn Ile Lys Xaa Tyr 
65                  70                  75                  80  


Tyr Gln Asp Arg Pro Phe Phe Arg 
                85              


<210> 5216
<211> 506
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<400> 5216
Met Ser Val Leu Ser Pro Gly Asp Leu Lys Pro Lys Arg Gly Ser Pro 
1               5                   10                  15      


His Arg Gly Ser Leu Asp Arg Xaa Asp Ala Ser Xaa Asp Leu Ala Met 
            20                  25                  30          


Arg Ser Trp Pro Ser Glu Leu Gly Ser Arg Xaa Cys Ser Xaa Ser Ala 
        35                  40                  45              


Xaa Xaa Xaa Ala Pro Ser Asn Ser Xaa Pro Ile Ala Arg His Pro Gly 
    50                  55                  60                  


Arg Xaa Lys Gly Tyr Asn Ser Asp Asp Asn Leu Cys Glu Pro Ser Leu 
65                  70                  75                  80  


Glu Phe Glu Val Pro Asn His Arg Gln Tyr Val Ser Arg Pro Ser Ser 
                85                  90                  95      


Leu Glu Ser Ser Arg Asn Xaa Ser Ser Asn Ser Ser Pro Leu Asn Leu 
            100                 105                 110         


Lys Gly Ser Ser Glu Gln Leu His Gly Arg Ser Glu Ser Phe Ser Ser 
        115                 120                 125             


Glu Asp Leu Ile Pro Ser Arg Asp Leu Ala Xaa Leu Pro Arg Glu Ala 
    130                 135                 140                 


Ser Xaa Pro Gly Arg Asn Ala Leu Gly Arg His Glu Tyr Pro Leu Pro 
145                 150                 155                 160 


Arg Asn Gly Pro Leu Pro Gln Glu Gly Ala Gln Lys Arg Gly Xaa Ala 
                165                 170                 175     


Pro Pro Tyr Val Gly Val Arg Pro Cys Ser Ala Ser Pro Ser Ser Glu 
            180                 185                 190         


Met Val Xaa Leu Glu Glu Phe Leu Glu Glu Ser Asn Arg Ser Ser Pro 
        195                 200                 205             


Xaa His Asp Xaa Pro Ser Cys Arg Asp Asp Leu Leu Ser Asp Tyr Phe 
    210                 215                 220                 


Arg Lys Ala Ser Asp Pro Pro Ala Ile Gly Gly Gln Pro Gly Pro Pro 
225                 230                 235                 240 


Ala Lys Lys Glu Gly Ala Lys Met Pro Xaa Asn Phe Val Ala Pro Xaa 
                245                 250                 255     


Val Lys Met Ala Ala Pro Xaa Ser Glu Gly Arg Pro Leu Lys Pro Gly 
            260                 265                 270         


Gln Tyr Val Lys Pro Asn Phe Arg Leu Xaa Glu Ala Glu Ala Pro Pro 
        275                 280                 285             


Ser Val Ala Pro Arg Gln Ala Gln Pro Pro Gln Ser Leu Ser Leu Gly 
    290                 295                 300                 


Arg Pro Arg Gln Ala Pro Glu Ala Leu Gly Gly Arg Glu Xaa Gly Ser 
305                 310                 315                 320 


His Xaa Leu Gln Ser Pro Ala Pro Pro Ser Ser His Ser Leu Ala Arg 
                325                 330                 335     


Glu Arg Xaa Pro Leu Val Gly Lys Ala Gly Ser Ser Cys Gln Gly Pro 
            340                 345                 350         


Gly Pro Arg Ser Arg Pro Leu Asp Xaa Arg Arg Phe Ser Leu Ala Pro 
        355                 360                 365             


Pro Lys Glu Glu Arg Leu Ala Pro Leu His Gln Ser Ala Xaa Ala Pro 
    370                 375                 380                 


Ala Ile Ala Xaa Ala Gly Ala Gly Ala Ala Ala Ala Gly Ser Gly Ser 
385                 390                 395                 400 


Asn Ser Gln Leu Leu His Phe Ser Pro Ala Ala Ala Pro Ala Ala Arg 
                405                 410                 415     


Xaa Lys Pro Lys Ala Pro Pro Arg Ser Gly Glu Val Ala Xaa Ile Xaa 
            420                 425                 430         


Pro Val Arg Ala Gly Leu Ser Leu Ser Glu Gly Asp Gly Val Pro Gly 
        435                 440                 445             


Gln Gly Cys Ser Glu Gly Leu Pro Ala Lys Ser Pro Gly Arg Ser Pro 
    450                 455                 460                 


Asp Leu Ala Pro His Leu Gly Arg Ala Leu Glu Asp Cys Ser Arg Gly 
465                 470                 475                 480 


Ser Val Ser Lys Ser Ser Pro Ala Ser Pro Glu Pro Gly Gly Asp Pro 
                485                 490                 495     


Gln Xaa Val Trp Tyr Glu Tyr Gly Cys Val 
            500                 505     


<210> 5217
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(99)
<223> Selenocysteine

<400> 5217
Xaa Ile Gly Ala Lys Ala Leu Val Lys Leu Ile Lys Pro Lys Lys Glu 
1               5                   10                  15      


Gly Ser Arg Glu Arg Leu Lys Ser Xaa Val Asp Ser Pro Pro Trp Gln 
            20                  25                  30          


Leu Glu Ser Ser Asp Pro Ala Ser Pro Ala Ala Ser Gln Pro Leu Arg 
        35                  40                  45              


Ser Gln Ala Glu Asn Pro Asp Xaa Pro Ala Leu Gly Ser Asn Cys Ala 
    50                  55                  60                  


Glu Glu Arg Asp Ala His Asn Gly Ser Val Gly Lys Ala Pro Pro Arg 
65                  70                  75                  80  


Lys Lys Ser Pro Phe Leu Lys Ser Lys Asn Lys Asp Lys Asp Lys Ser 
                85                  90                  95      


Pro Xaa Xaa His Pro Ala Leu Ser Lys Arg Leu Arg Phe Trp Ser Ser 
            100                 105                 110         


Ser Asp Ile Pro Ser Ser Pro Asn Glu Pro Leu Ser Phe Ser Asp Ile 
        115                 120                 125             


Gly Asp Phe 
    130     


<210> 5218
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 5218
Met Asn Ser Gly Val Cys Leu Cys Val Leu Met Ala Val Leu Ala Ala 
1               5                   10                  15      


Gly Ala Leu Xaa Gln Pro Val Pro Pro Ala Asp Pro Ala Gly Ser Gly 
            20                  25                  30          


Leu Gln Arg Ala Glu Glu Ala Pro Arg Arg Gln Leu Arg Val Ser Gln 
        35                  40                  45              


Arg Xaa Asp Gly Glu Ser Arg Ala His Leu Gly Ala Leu Leu Ala Arg 
    50                  55                  60                  


Tyr Ile Gln Gln Ala Arg Lys Ala Pro Ser Gly Arg Met Ser Ile Val 
65                  70                  75                  80  


Lys Asn Leu Gln Asn Leu Asp Pro Ser His Arg Ile Ser Asp Arg Asp 
                85                  90                  95      


Tyr Met Gly Trp Met Asp Phe Gly Arg Arg Ser Ala Glu Glu Tyr Glu 
            100                 105                 110         


Tyr Pro Ser 
        115 


<210> 5219
<211> 428
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(409)
<223> Selenocysteine

<400> 5219
Met Asp Val Val Asp Ser Leu Leu Val Asn Gly Ser Asn Ile Xaa Pro 
1               5                   10                  15      


Pro Cys Glu Leu Gly Leu Glu Asn Glu Xaa Leu Phe Cys Leu Asp Gln 
            20                  25                  30          


Pro Arg Pro Ser Lys Glu Trp Gln Pro Ala Val Gln Ile Leu Leu Tyr 
        35                  40                  45              


Ser Leu Ile Phe Leu Leu Ser Val Leu Gly Asn Xaa Leu Val Ile Xaa 
    50                  55                  60                  


Val Leu Ile Arg Asn Lys Arg Met Arg Xaa Val Xaa Asn Ile Phe Leu 
65                  70                  75                  80  


Leu Ser Leu Ala Val Ser Asp Leu Met Leu Cys Leu Phe Cys Met Pro 
                85                  90                  95      


Phe Asn Leu Ile Pro Asn Leu Leu Lys Asp Phe Ile Phe Gly Ser Ala 
            100                 105                 110         


Val Cys Lys Xaa Xaa Xaa Tyr Phe Met Gly Xaa Ser Val Ser Val Ser 
        115                 120                 125             


Xaa Phe Asn Leu Val Ala Ile Ser Leu Glu Arg Tyr Gly Ala Ile Cys 
    130                 135                 140                 


Lys Pro Leu Gln Ser Arg Val Trp Gln Xaa Lys Ser His Ala Leu Lys 
145                 150                 155                 160 


Val Ile Ala Ala Xaa Trp Cys Leu Ser Phe Xaa Ile Met Xaa Pro Tyr 
                165                 170                 175     


Pro Ile Tyr Ser Asn Leu Val Pro Phe Xaa Lys Asn Asn Asn Gln Xaa 
            180                 185                 190         


Ala Asn Met Cys Arg Phe Leu Leu Pro Asn Asp Val Met Gln Gln Ser 
        195                 200                 205             


Trp His Xaa Phe Leu Leu Leu Ile Leu Phe Leu Ile Pro Gly Ile Val 
    210                 215                 220                 


Met Met Val Ala Tyr Gly Leu Ile Ser Leu Glu Leu Tyr Gln Gly Ile 
225                 230                 235                 240 


Lys Phe Glu Ala Ser Gln Lys Lys Ser Ala Lys Glu Arg Lys Pro Ser 
                245                 250                 255     


Xaa Xaa Ser Ser Gly Lys Tyr Glu Asp Ser Asp Gly Cys Tyr Leu Gln 
            260                 265                 270         


Lys Xaa Arg Pro Pro Arg Lys Leu Glu Leu Arg Gln Leu Ser Xaa Gly 
        275                 280                 285             


Ser Ser Ser Arg Ala Asn Arg Ile Arg Ser Asn Ser Ser Ala Ala Asn 
    290                 295                 300                 


Leu Met Ala Lys Lys Arg Val Ile Arg Met Leu Ile Val Ile Val Val 
305                 310                 315                 320 


Leu Phe Phe Leu Cys Trp Met Pro Ile Phe Ser Ala Asn Ala Trp Arg 
                325                 330                 335     


Ala Tyr Asp Xaa Ala Ser Ala Glu Arg Arg Leu Ser Gly Xaa Pro Ile 
            340                 345                 350         


Ser Phe Ile Leu Leu Leu Ser Tyr Xaa Ser Ser Cys Val Asn Pro Ile 
        355                 360                 365             


Ile Tyr Cys Phe Met Asn Lys Arg Phe Arg Leu Gly Phe Met Ala Xaa 
    370                 375                 380                 


Phe Pro Cys Cys Pro Asn Pro Gly Pro Pro Gly Ala Arg Gly Glu Val 
385                 390                 395                 400 


Gly Glu Glu Glu Glu Gly Gly Xaa Xaa Gly Ala Ser Leu Ser Arg Phe 
                405                 410                 415     


Ser Tyr Ser His Met Ser Ala Ser Val Pro Pro Gln 
            420                 425             


<210> 5220
<211> 87
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 5220
Met Glu Leu Leu Lys Leu Asn Arg Ser Val Gln Gly Xaa Gly Pro Gly 
1               5                   10                  15      


Pro Gly Ala Ser Leu Cys Arg Pro Gly Ala Pro Leu Leu Asn Ser Ser 
            20                  25                  30          


Ser Val Gly Asn Leu Ser Cys Glu Pro Pro Arg Ile Arg Gly Ala Gly 
        35                  40                  45              


Xaa Arg Asp Arg Xaa Asn Xaa Asp Leu Leu Asn Xaa Arg Arg Arg Xaa 
    50                  55                  60                  


Glu Leu Ser Gln Ser Ser Glu Ser Pro Gly Leu Met Pro Val Phe Leu 
65                  70                  75                  80  


Ile Pro Arg Lys Met Met Arg 
                85          


<210> 5221
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<400> 5221
Met Glu Leu Leu Lys Leu Asn Arg Ser Val Gln Gly Xaa Gly Pro Gly 
1               5                   10                  15      


Pro Gly Ala Ser Leu Cys Arg Pro Gly Ala Pro Leu Leu Asn Ser Ser 
            20                  25                  30          


Ser Val Gly Asn Leu Ser Cys Glu Pro Pro Arg Ile Arg Gly Ala Gly 
        35                  40                  45              


Xaa Arg Glu Leu Glu Leu Ala Ile Arg Ile Xaa Leu Tyr Ala Val Ile 
    50                  55                  60                  


Phe Leu Met Ser Val Gly Gly Asn Met Leu Ile Ile Val Val Leu Gly 
65                  70                  75                  80  


Leu Ser Arg Arg Leu Arg Xaa Val Xaa Asn Ala Phe Leu Leu Ser Leu 
                85                  90                  95      


Ala Val Ser Asp Leu Leu Leu Ala Val Ala Cys Met Pro Phe Xaa Leu 
            100                 105                 110         


Leu Pro Asn Leu Met Gly Xaa Phe Ile Phe Gly Xaa Val Ile Cys Lys 
        115                 120                 125             


Ala Val Ser Tyr Leu Met Gly Gly 
    130                 135     


<210> 5222
<211> 447
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<400> 5222
Met Glu Leu Leu Lys Leu Asn Arg Ser Val Gln Gly Xaa Gly Pro Gly 
1               5                   10                  15      


Pro Gly Ala Ser Leu Cys Arg Pro Gly Ala Pro Leu Leu Asn Ser Ser 
            20                  25                  30          


Ser Val Gly Asn Leu Ser Cys Glu Pro Pro Arg Ile Arg Gly Ala Gly 
        35                  40                  45              


Xaa Arg Glu Leu Glu Leu Ala Ile Arg Ile Xaa Leu Tyr Ala Val Ile 
    50                  55                  60                  


Phe Leu Met Ser Val Gly Gly Asn Met Leu Ile Ile Val Val Leu Gly 
65                  70                  75                  80  


Leu Ser Arg Arg Leu Arg Xaa Val Xaa Asn Ala Phe Leu Leu Ser Leu 
                85                  90                  95      


Ala Val Ser Asp Leu Leu Leu Ala Val Ala Cys Met Pro Phe Xaa Leu 
            100                 105                 110         


Leu Pro Asn Leu Met Gly Xaa Phe Ile Phe Gly Xaa Val Ile Cys Lys 
        115                 120                 125             


Ala Val Ser Tyr Leu Met Gly Val Ser Val Ser Val Ser Xaa Leu Ser 
    130                 135                 140                 


Leu Val Ala Ile Ala Leu Glu Arg Tyr Ser Ala Ile Cys Arg Pro Leu 
145                 150                 155                 160 


Gln Ala Arg Val Trp Gln Xaa Arg Ser His Ala Ala Arg Val Ile Val 
                165                 170                 175     


Ala Xaa Trp Leu Leu Ser Gly Leu Leu Met Val Pro Tyr Pro Val Tyr 
            180                 185                 190         


Xaa Val Val Gln Pro Val Gly Pro Arg Val Leu Gln Cys Val His Arg 
        195                 200                 205             


Trp Pro Ser Ala Arg Val Arg Gln Xaa Trp Ser Val Leu Leu Leu Leu 
    210                 215                 220                 


Leu Leu Phe Phe Ile Pro Gly Val Val Met Ala Val Ala Tyr Gly Leu 
225                 230                 235                 240 


Ile Ser Arg Glu Leu Tyr Leu Gly Leu Arg Phe Asp Gly Asp Ser Asp 
                245                 250                 255     


Ser Asp Ser Gln Ser Arg Val Arg Asn Gln Gly Gly Leu Pro Gly Ala 
            260                 265                 270         


Val His Gln Asn Gly Arg Cys Arg Pro Glu Xaa Gly Ala Val Gly Glu 
        275                 280                 285             


Asp Ser Asp Gly Cys Tyr Val Gln Leu Pro Arg Ser Arg Pro Ala Leu 
    290                 295                 300                 


Glu Leu Xaa Ala Leu Xaa Ala Pro Gly Pro Gly Ser Gly Ser Arg Pro 
305                 310                 315                 320 


Xaa Gln Ala Lys Leu Leu Ala Lys Lys Arg Val Val Arg Met Leu Leu 
                325                 330                 335     


Val Ile Val Val Leu Phe Phe Leu Cys Trp Leu Pro Val Tyr Ser Ala 
            340                 345                 350         


Asn Xaa Trp Arg Ala Phe Asp Gly Pro Gly Ala His Arg Ala Leu Ser 
        355                 360                 365             


Gly Ala Pro Ile Ser Phe Ile His Leu Leu Ser Tyr Ala Ser Ala Cys 
    370                 375                 380                 


Val Asn Pro Leu Val Tyr Cys Phe Met His Arg Arg Phe Arg Gln Ala 
385                 390                 395                 400 


Cys Leu Glu Xaa Cys Ala Arg Cys Cys Pro Arg Pro Pro Arg Ala Arg 
                405                 410                 415     


Pro Arg Ala Leu Pro Asp Glu Asp Pro Pro Xaa Pro Ser Ile Ala Ser 
            420                 425                 430         


Leu Ser Arg Leu Ser Tyr Xaa Xaa Ile Ser Xaa Leu Gly Pro Gly 
        435                 440                 445         


<210> 5223
<211> 516
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<400> 5223
Met Glu Leu Leu Lys Leu Asn Arg Ser Val Gln Gly Xaa Gly Pro Gly 
1               5                   10                  15      


Pro Gly Ala Ser Leu Cys Arg Pro Gly Ala Pro Leu Leu Asn Ser Ser 
            20                  25                  30          


Ser Val Gly Asn Leu Ser Cys Glu Pro Pro Arg Ile Arg Gly Ala Gly 
        35                  40                  45              


Xaa Arg Glu Leu Glu Leu Ala Ile Arg Ile Xaa Leu Tyr Ala Val Ile 
    50                  55                  60                  


Phe Leu Met Ser Val Gly Gly Asn Met Leu Ile Ile Val Val Leu Gly 
65                  70                  75                  80  


Leu Ser Arg Arg Leu Arg Xaa Val Xaa Asn Ala Phe Leu Leu Ser Leu 
                85                  90                  95      


Ala Val Ser Asp Leu Leu Leu Ala Val Ala Cys Met Pro Phe Xaa Leu 
            100                 105                 110         


Leu Pro Asn Leu Met Gly Xaa Phe Ile Phe Gly Xaa Val Ile Cys Lys 
        115                 120                 125             


Ala Val Ser Tyr Leu Met Gly Val Ser Val Ser Val Ser Xaa Leu Ser 
    130                 135                 140                 


Leu Val Ala Ile Ala Leu Glu Arg Tyr Ser Ala Ile Cys Arg Pro Leu 
145                 150                 155                 160 


Gln Ala Arg Val Trp Gln Xaa Arg Ser His Ala Ala Arg Val Ile Val 
                165                 170                 175     


Ala Xaa Trp Leu Leu Ser Gly Leu Leu Met Val Pro Tyr Pro Val Tyr 
            180                 185                 190         


Xaa Val Val Gln Pro Val Gly Pro Arg Val Leu Gln Cys Val His Arg 
        195                 200                 205             


Trp Pro Ser Ala Arg Val Arg Gln Xaa Trp Ser Val Leu Leu Leu Leu 
    210                 215                 220                 


Leu Leu Phe Phe Ile Pro Gly Val Val Met Ala Val Ala Tyr Gly Leu 
225                 230                 235                 240 


Ile Ser Arg Glu Leu Tyr Leu Gly Leu Arg Phe Asp Gly Asp Ser Asp 
                245                 250                 255     


Ser Asp Ser Gln Ser Arg Val Arg Asn Gln Gly Gly Leu Pro Gly Gly 
            260                 265                 270         


Ala Gly Pro Arg Glu Gln Asn Leu Gly Glu Ala Glu Leu Trp Arg Ala 
        275                 280                 285             


Xaa Gly Pro Ala Gly Val Gly Gly Xaa Glu Met Lys Val Arg Val Arg 
    290                 295                 300                 


Arg Lys Leu Glu Met Glu Leu Ser Trp Glu Arg Arg Ser Gly Gly Asp 
305                 310                 315                 320 


Trp Ala Gly Asp Trp Gly Asp Ser Pro Phe Ser Leu Xaa Ala His Pro 
                325                 330                 335     


Leu Cys Ser Gly Ala Val His Gln Asn Gly Arg Cys Arg Pro Glu Xaa 
            340                 345                 350         


Gly Ala Val Gly Glu Asp Ser Asp Gly Cys Tyr Val Gln Leu Pro Arg 
        355                 360                 365             


Ser Arg Pro Ala Leu Glu Leu Xaa Ala Leu Xaa Ala Pro Gly Pro Gly 
    370                 375                 380                 


Ser Gly Ser Arg Pro Xaa Gln Ala Lys Leu Leu Ala Lys Lys Arg Val 
385                 390                 395                 400 


Val Arg Met Leu Leu Val Ile Val Val Leu Phe Phe Leu Cys Trp Leu 
                405                 410                 415     


Pro Val Tyr Ser Ala Asn Xaa Trp Arg Ala Phe Asp Gly Pro Gly Ala 
            420                 425                 430         


His Arg Ala Leu Ser Gly Ala Pro Ile Ser Phe Ile His Leu Leu Ser 
        435                 440                 445             


Tyr Ala Ser Ala Cys Val Asn Pro Leu Val Tyr Cys Phe Met His Arg 
    450                 455                 460                 


Arg Phe Arg Gln Ala Cys Leu Glu Xaa Cys Ala Arg Cys Cys Pro Arg 
465                 470                 475                 480 


Pro Pro Arg Ala Arg Pro Arg Ala Leu Pro Asp Glu Asp Pro Pro Xaa 
                485                 490                 495     


Pro Ser Ile Ala Ser Leu Ser Arg Leu Ser Tyr Xaa Xaa Ile Ser Xaa 
            500                 505                 510         


Leu Gly Pro Gly 
        515     


<210> 5224
<211> 363
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<400> 5224
Met Glu Leu Leu Lys Leu Asn Arg Ser Val Gln Gly Xaa Gly Pro Gly 
1               5                   10                  15      


Pro Gly Ala Ser Leu Cys Arg Pro Gly Ala Pro Leu Leu Asn Ser Ser 
            20                  25                  30          


Ser Val Gly Asn Leu Ser Cys Glu Pro Pro Arg Ile Arg Gly Ala Gly 
        35                  40                  45              


Xaa Arg Gly Val Ser Val Ser Val Ser Xaa Leu Ser Leu Val Ala Ile 
    50                  55                  60                  


Ala Leu Glu Arg Tyr Ser Ala Ile Cys Arg Pro Leu Gln Ala Arg Val 
65                  70                  75                  80  


Trp Gln Xaa Arg Ser His Ala Ala Arg Val Ile Val Ala Xaa Trp Leu 
                85                  90                  95      


Leu Ser Gly Leu Leu Met Val Pro Tyr Pro Val Tyr Xaa Val Val Gln 
            100                 105                 110         


Pro Val Gly Pro Arg Val Leu Gln Cys Val His Arg Trp Pro Ser Ala 
        115                 120                 125             


Arg Val Arg Gln Xaa Trp Ser Val Leu Leu Leu Leu Leu Leu Phe Phe 
    130                 135                 140                 


Ile Pro Gly Val Val Met Ala Val Ala Tyr Gly Leu Ile Ser Arg Glu 
145                 150                 155                 160 


Leu Tyr Leu Gly Leu Arg Phe Asp Gly Asp Ser Asp Ser Asp Ser Gln 
                165                 170                 175     


Ser Arg Val Arg Asn Gln Gly Gly Leu Pro Gly Ala Val His Gln Asn 
            180                 185                 190         


Gly Arg Cys Arg Pro Glu Xaa Gly Ala Val Gly Glu Asp Ser Asp Gly 
        195                 200                 205             


Cys Tyr Val Gln Leu Pro Arg Ser Arg Pro Ala Leu Glu Leu Xaa Ala 
    210                 215                 220                 


Leu Xaa Ala Pro Gly Pro Gly Ser Gly Ser Arg Pro Xaa Gln Ala Lys 
225                 230                 235                 240 


Leu Leu Ala Lys Lys Arg Val Val Arg Met Leu Leu Val Ile Val Val 
                245                 250                 255     


Leu Phe Phe Leu Cys Trp Leu Pro Val Tyr Ser Ala Asn Xaa Trp Arg 
            260                 265                 270         


Ala Phe Asp Gly Pro Gly Ala His Arg Ala Leu Ser Gly Ala Pro Ile 
        275                 280                 285             


Ser Phe Ile His Leu Leu Ser Tyr Ala Ser Ala Cys Val Asn Pro Leu 
    290                 295                 300                 


Val Tyr Cys Phe Met His Arg Arg Phe Arg Gln Ala Cys Leu Glu Xaa 
305                 310                 315                 320 


Cys Ala Arg Cys Cys Pro Arg Pro Pro Arg Ala Arg Pro Arg Ala Leu 
                325                 330                 335     


Pro Asp Glu Asp Pro Pro Xaa Pro Ser Ile Ala Ser Leu Ser Arg Leu 
            340                 345                 350         


Ser Tyr Xaa Xaa Ile Ser Xaa Leu Gly Pro Gly 
        355                 360             


<210> 5225
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<400> 5225
Met Gln Ile Ile Xaa Xaa Ala Leu Val Cys Leu Leu Leu Ala Gly Met 
1               5                   10                  15      


Trp Pro Glu Asp Val Asp Ser Lys Ser Met Gln Val Pro Phe Ser Arg 
            20                  25                  30          


Cys Cys Phe Ser Phe Ala Glu Gln Glu Ile Pro Leu Arg Ala Ile Leu 
        35                  40                  45              


Cys Tyr Arg Asn Xaa Ser Ser Ile Cys Ser Asn Glu Gly Leu Ile Phe 
    50                  55                  60                  


Lys Leu Lys Arg Gly Lys Glu Ala Cys Ala Leu Asp Xaa Val Gly Trp 
65                  70                  75                  80  


Val Gln Arg His Arg Lys Met Leu Arg His Cys Pro Ser Lys Arg Lys 
                85                  90                  95      


<210> 5226
<211> 97
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<400> 5226
Met Lys Val Ser Ala Ala Leu Leu Trp Leu Leu Leu Ile Ala Ala Ala 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gly Pro Ala Ser Val Pro Xaa Xaa Cys 
            20                  25                  30          


Cys Phe Asn Leu Ala Asn Arg Lys Ile Pro Leu Gln Arg Leu Glu Ser 
        35                  40                  45              


Tyr Arg Arg Ile Xaa Ser Gly Lys Cys Pro Gln Lys Ala Val Ile Phe 
    50                  55                  60                  


Lys Xaa Lys Leu Ala Lys Asp Ile Cys Ala Asp Pro Lys Lys Lys Trp 
65                  70                  75                  80  


Val Gln Asp Ser Met Lys Tyr Leu Asp Gln Lys Ser Pro Xaa Pro Lys 
                85                  90                  95      


Pro 
    


<210> 5227
<211> 98
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 5227
Met Lys Val Ser Ala Val Leu Leu Cys Leu Leu Leu Met Xaa Ala Ala 
1               5                   10                  15      


Phe Asn Pro Gln Gly Leu Ala Gln Pro Asp Ala Leu Asn Val Pro Ser 
            20                  25                  30          


Xaa Cys Cys Phe Xaa Phe Ser Ser Lys Lys Ile Ser Leu Gln Arg Leu 
        35                  40                  45              


Lys Ser Tyr Val Ile Xaa Xaa Ser Arg Cys Pro Gln Lys Ala Val Ile 
    50                  55                  60                  


Phe Arg Xaa Lys Leu Gly Lys Glu Ile Cys Ala Asp Pro Lys Glu Lys 
65                  70                  75                  80  


Trp Val Gln Asn Tyr Met Lys His Leu Gly Arg Lys Ala His Xaa Leu 
                85                  90                  95      


Lys Xaa 
        


<210> 5228
<211> 63
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<400> 5228
Xaa Val Pro Ser Xaa Cys Cys Phe Xaa Phe Ser Ser Lys Lys Ile Ser 
1               5                   10                  15      


Leu Gln Arg Leu Lys Ser Tyr Val Ile Xaa Xaa Ser Ser Phe Arg Xaa 
            20                  25                  30          


Lys Leu Gly Lys Glu Ile Cys Ala Asp Pro Lys Glu Lys Trp Val Gln 
        35                  40                  45              


Asn Tyr Met Lys His Leu Gly Arg Lys Ala His Xaa Leu Lys Xaa 
    50                  55                  60              


<210> 5229
<211> 109
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 5229
Met Lys Ile Ser Val Ala Ala Ile Pro Phe Phe Leu Leu Ile Xaa Ile 
1               5                   10                  15      


Ala Leu Gly Xaa Lys Xaa Glu Ser Ser Ser Gln Xaa Gly Gly Lys Pro 
            20                  25                  30          


Lys Val Val Lys Ile Gln Leu Lys Leu Val Gly Gly Pro Tyr His Pro 
        35                  40                  45              


Ser Glu Cys Cys Phe Xaa Tyr Xaa Xaa Tyr Lys Ile Pro Arg Gln Arg 
    50                  55                  60                  


Ile Met Asp Tyr Tyr Glu Xaa Asn Ser Gln Cys Ser Lys Pro Gly Ile 
65                  70                  75                  80  


Val Phe Ile Xaa Lys Arg Gly His Ser Val Cys Xaa Asn Pro Ser Asp 
                85                  90                  95      


Lys Trp Val Gln Asp Tyr Ile Lys Asp Met Lys Glu Asn 
            100                 105                 


<210> 5230
<211> 65
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<400> 5230
Met Lys Ile Ser Val Ala Ala Ile Pro Phe Phe Leu Leu Ile Xaa Ile 
1               5                   10                  15      


Ala Leu Gly Xaa Lys Xaa Glu Ser Ser Ser Arg Gly Pro Tyr His Pro 
            20                  25                  30          


Ser Glu Cys Cys Phe Xaa Tyr Xaa Xaa Tyr Lys Ile Pro Arg Gln Arg 
        35                  40                  45              


Ile Met Asp Tyr Tyr Glu Xaa Asn Ser Gln Cys Ser Lys Pro Gly Ile 
    50                  55                  60                  


Val 
65  


<210> 5231
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<400> 5231
Met Lys Ile Ser Val Ala Ala Ile Pro Phe Phe Leu Leu Ile Xaa Ile 
1               5                   10                  15      


Ala Leu Gly Xaa Lys Xaa Glu Ser Ser Ser Arg Gly Pro Tyr His Pro 
            20                  25                  30          


Ser Glu Cys Cys Phe Xaa Tyr Xaa Xaa Tyr Lys Ile Pro Arg Gln Arg 
        35                  40                  45              


Ile Met Asp Tyr Tyr Glu Xaa Asn Ser Gln Cys Ser Lys Pro Gly Ile 
    50                  55                  60                  


Val Phe Ile Xaa Lys Arg Gly His Ser Val Cys Xaa Asn Pro Ser Asp 
65                  70                  75                  80  


Lys Trp Val Gln Asp Tyr Ile Lys Asp Met Lys Glu Asn 
                85                  90              


<210> 5232
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 5232
Met Arg Lys Ala Tyr Ser Pro Leu Gln Val Leu Arg Gly Cys Leu Leu 
1               5                   10                  15      


Leu Pro Ser Leu Leu His Ala Leu Ser Leu Gln Glu Gln Pro Met Val 
            20                  25                  30          


Trp Pro Leu Xaa Arg Gly Pro Ser Ser Ala Ser Asp Ala Leu Ser Ser 
        35                  40                  45              


Gly Gly Pro Tyr His Pro Ser Glu Cys Cys Phe Xaa Tyr Xaa Xaa Tyr 
    50                  55                  60                  


Lys Ile Pro Arg Gln Arg Ile Met Asp Tyr Tyr Glu Xaa Asn Ser Gln 
65                  70                  75                  80  


Cys Ser Lys Pro Gly Ile Val Phe Ile Xaa Lys Arg Gly His Ser Val 
                85                  90                  95      


Cys Xaa Asn Pro Ser Asp Lys Trp Val Gln Asp Tyr Ile Lys Asp Met 
            100                 105                 110         


Lys Glu Asn 
        115 


<210> 5233
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 5233
Met Lys Val Ser Val Ala Ala Leu Ser Cys Leu Met Leu Val Ala Val 
1               5                   10                  15      


Leu Gly Ser Gln Ala Gln Phe Ile Asn Asp Ala Glu Xaa Glu Leu Met 
            20                  25                  30          


Met Ser Lys Leu Pro Leu Glu Asn Pro Val Val Leu Asn Ser Phe His 
        35                  40                  45              


Phe Ala Ala Asp Cys Cys Xaa Ser Tyr Ile Ser Gln Ser Ile Pro Cys 
    50                  55                  60                  


Ser Leu Met Lys Ser Tyr Phe Glu Xaa Ser Ser Glu Cys Ser Lys Pro 
65                  70                  75                  80  


Gly Val Ile Phe Leu Xaa Lys Lys Gly Arg Gln Val Cys Ala Lys Pro 
                85                  90                  95      


Ser Gly Pro Gly Val Gln Asp Cys Met Lys Lys Leu Lys Pro Tyr Ser 
            100                 105                 110         


Ile 
    


<210> 5234
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 5234
Met Lys Val Ser Val Ala Ala Leu Ser Cys Leu Met Leu Val Ala Val 
1               5                   10                  15      


Leu Gly Ser Gln Ala Gln Phe Xaa Asn Asp Ala Glu Xaa Glu Leu Met 
            20                  25                  30          


Met Ser Lys Leu Pro Leu Glu Asn Pro Val Val Leu Asn Ser Phe His 
        35                  40                  45              


Phe Ala Ala Asp Cys Cys Xaa Ser Tyr Ile Ser Gln Ser Ile Pro Cys 
    50                  55                  60                  


Ser Leu Met Lys Ser Tyr Phe Glu Xaa Ser Ser Glu Cys Ser Lys Pro 
65                  70                  75                  80  


Gly Val Ile Phe Leu Xaa Lys Lys Gly Arg Gln Val Cys Ala Lys Pro 
                85                  90                  95      


Ser Gly Pro Gly Val Gln Asp Cys Met Lys Lys Leu Lys Pro Tyr Ser 
            100                 105                 110         


Ile 
    


<210> 5235
<211> 61
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<400> 5235
Xaa Cys Xaa Ser Tyr Ile Ser Gln Ser Ile Pro Cys Ser Leu Met Lys 
1               5                   10                  15      


Ser Tyr Phe Glu Xaa Ser Ser Glu Cys Ser Lys Pro Gly Val Ile Phe 
            20                  25                  30          


Leu Xaa Lys Lys Gly Arg Gln Val Cys Ala Lys Pro Ser Gly Pro Gly 
        35                  40                  45              


Val Gln Asp Cys Met Lys Lys Leu Lys Pro Tyr Ser Ile 
    50                  55                  60      


<210> 5236
<211> 120
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<400> 5236
Met Lys Val Ser Glu Ala Ala Leu Ser Leu Leu Val Leu Ile Leu Ile 
1               5                   10                  15      


Ile Xaa Ser Ala Ser Arg Ser Gln Pro Lys Val Pro Glu Trp Val Asn 
            20                  25                  30          


Xaa Pro Ser Xaa Cys Cys Leu Lys Tyr Tyr Glu Lys Val Leu Pro Arg 
        35                  40                  45              


Arg Leu Val Val Gly Tyr Arg Lys Ala Leu Asn Cys His Leu Pro Ala 
    50                  55                  60                  


Ile Ile Phe Val Xaa Lys Arg Asn Arg Glu Val Cys Xaa Asn Pro Asn 
65                  70                  75                  80  


Asp Asp Trp Val Gln Glu Tyr Ile Lys Asp Pro Asn Leu Pro Leu Leu 
                85                  90                  95      


Pro Xaa Arg Asn Leu Ser Xaa Val Lys Ile Ile Xaa Ala Lys Asn Gly 
            100                 105                 110         


Gln Pro Gln Leu Leu Asn Ser Gln 
        115                 120 


<210> 5237
<211> 53
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(38)
<223> Selenocysteine

<400> 5237
Met Lys Val Ser Glu Ala Ala Leu Ser Leu Leu Val Leu Ile Leu Ile 
1               5                   10                  15      


Ile Xaa Ser Ala Ser Arg Ser Gln Pro Ser Trp Ser Ala Val Ser Arg 
            20                  25                  30          


Ser Arg Leu Xaa Xaa Xaa Ser Ala Ser Arg Val Gln Val Ile Leu Leu 
        35                  40                  45              


Pro Gln Pro Pro Glu 
    50              


<210> 5238
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<400> 5238
Xaa Val Pro Glu Trp Val Asn Xaa Pro Ser Xaa Cys Cys Leu Lys Tyr 
1               5                   10                  15      


Tyr Glu Lys Val Leu Pro Arg Arg Leu Val Val Gly Tyr Arg Lys Ala 
            20                  25                  30          


Leu Asn Cys His Leu Pro Ala Ile Ile Phe Val Xaa Lys Arg Asn Arg 
        35                  40                  45              


Glu Val Cys Xaa Asn Pro Asn Asp Asp Trp Val Gln Glu Tyr Ile Lys 
    50                  55                  60                  


Asp Pro Asn Leu Pro Leu Leu Pro Xaa Arg Asn Leu Ser Xaa Val Lys 
65                  70                  75                  80  


Ile Ile Xaa Ala Lys Asn Gly Gln Pro Gln Leu Leu Asn Ser Gln 
                85                  90                  95  


<210> 5239
<211> 94
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 5239
Met Ala Pro Leu Lys Met Leu Ala Leu Val Xaa Leu Leu Leu Gly Ala 
1               5                   10                  15      


Ser Leu Gln His Ile His Ala Ala Arg Gly Xaa Asn Val Gly Arg Glu 
            20                  25                  30          


Cys Cys Leu Glu Tyr Phe Lys Gly Ala Ile Pro Leu Arg Lys Leu Lys 
        35                  40                  45              


Xaa Trp Tyr Gln Xaa Ser Glu Asp Cys Ser Arg Asp Ala Ile Val Phe 
    50                  55                  60                  


Val Xaa Val Gln Gly Arg Ala Ile Cys Ser Asp Pro Asn Asn Lys Arg 
65                  70                  75                  80  


Val Lys Asn Ala Val Lys Tyr Leu Gln Ser Leu Glu Arg Ser 
                85                  90                  


<210> 5240
<211> 89
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<400> 5240
Met Lys Gly Leu Ala Ala Ala Leu Leu Val Leu Val Cys Xaa Met Ala 
1               5                   10                  15      


Leu Cys Ser Cys Ala Gln Val Gly Xaa Asn Lys Glu Leu Cys Cys Leu 
            20                  25                  30          


Val Tyr Xaa Ser Trp Gln Ile Pro Gln Lys Phe Ile Val Asp Tyr Ser 
        35                  40                  45              


Glu Xaa Ser Pro Gln Cys Pro Lys Pro Gly Val Ile Leu Leu Xaa Lys 
    50                  55                  60                  


Arg Gly Arg Gln Ile Cys Ala Asp Pro Asn Lys Lys Trp Val Gln Lys 
65                  70                  75                  80  


Tyr Ile Ser Asp Leu Lys Leu Asn Ala 
                85                  


<210> 5241
<211> 104
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 5241
Met Ala Leu Leu Leu Ala Leu Ser Leu Leu Val Leu Trp Xaa Ser Pro 
1               5                   10                  15      


Ala Pro Xaa Leu Ser Gly Xaa Asn Asp Ala Glu Asp Cys Cys Leu Ser 
            20                  25                  30          


Val Xaa Gln Lys Pro Ile Pro Gly Tyr Ile Val Arg Asn Phe His Tyr 
        35                  40                  45              


Leu Leu Ile Lys Asp Gly Cys Arg Val Pro Ala Val Val Phe Xaa Xaa 
    50                  55                  60                  


Leu Arg Gly Arg Gln Leu Cys Ala Pro Pro Asp Gln Pro Trp Val Glu 
65                  70                  75                  80  


Arg Ile Ile Gln Arg Leu Gln Arg Xaa Ser Ala Lys Ala Ser Leu Ala 
                85                  90                  95      


Leu Pro Gly Pro Val Ser Ser Leu 
            100                 


<210> 5242
<211> 98
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 5242
Met Ala Leu Leu Leu Ala Leu Ser Leu Leu Val Leu Trp Xaa Ser Pro 
1               5                   10                  15      


Ala Pro Xaa Leu Ser Gly Xaa Asn Asp Ala Glu Asp Cys Cys Leu Ser 
            20                  25                  30          


Val Xaa Gln Lys Pro Ile Pro Gly Tyr Ile Val Arg Asn Phe His Tyr 
        35                  40                  45              


Leu Leu Ile Lys Asp Gly Cys Arg Val Pro Ala Val Val Phe Xaa Xaa 
    50                  55                  60                  


Leu Arg Gly Arg Gln Leu Cys Ala Pro Pro Asp Gln Pro Trp Val Glu 
65                  70                  75                  80  


Arg Ile Ile Gln Arg Leu Gln Arg Xaa Ser Ala Lys Met Lys Arg Arg 
                85                  90                  95      


Ser Ser 
        


<210> 5243
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<400> 5243
Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Ile Ala Ala Xaa 
1               5                   10                  15      


Phe Ile Pro Gln Gly Leu Ala Gln Pro Asp Ala Ile Asn Ala Pro Val 
            20                  25                  30          


Xaa Cys Cys Tyr Asn Phe Xaa Asn Arg Lys Ile Ser Val Gln Arg Leu 
        35                  40                  45              


Ala Ser Tyr Arg Arg Ile Xaa Ser Ser Lys Cys Pro Lys Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Xaa Ile Val Ala Lys Glu Ile Cys Ala Asp Pro Lys Gln 
65                  70                  75                  80  


Lys Trp Val Gln Asp Ser Met Asp His Leu Asp Lys Gln Xaa Gln Xaa 
                85                  90                  95      


Pro Lys Xaa 
            


<210> 5244
<211> 65
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<400> 5244
Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Ile Ala Ala Xaa 
1               5                   10                  15      


Phe Ile Pro Gln Gly Leu Ala Gln Pro Asp Ala Ile Asn Ala Pro Val 
            20                  25                  30          


Xaa Cys Cys Tyr Asn Phe Xaa Asn Arg Lys Ile Ser Val Gln Arg Leu 
        35                  40                  45              


Ala Ser Tyr Arg Arg Ile Xaa Ser Ser Lys Cys Pro Lys Glu Ala Val 
    50                  55                  60                  


Met 
65  


<210> 5245
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 5245
Met Cys Cys Xaa Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ala Ser Asn Phe Asp Cys 
            20                  25                  30          


Cys Leu Gly Tyr Xaa Asp Arg Ile Leu His Pro Lys Phe Ile Val Gly 
        35                  40                  45              


Phe Xaa Arg Gln Leu Ala Asn Glu Gly Cys Asp Ile Asn Ala Ile Ile 
    50                  55                  60                  


Phe His Xaa Lys Lys Lys Leu Ser Val Cys Ala Asn Pro Lys Gln Xaa 
65                  70                  75                  80  


Trp Val Lys Tyr Ile Val Arg Leu Leu Ser Lys Lys Val Lys Asn Met 
                85                  90                  95      


<210> 5246
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<400> 5246
Met Cys Cys Xaa Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ser Asn Phe Asp Cys Cys 
            20                  25                  30          


Leu Gly Tyr Xaa Asp Arg Ile Leu His Pro Lys Phe Ile Val Gly Phe 
        35                  40                  45              


Xaa Arg Gln Leu Ala Asn Glu Gly Cys Asp Ile Asn Ala Ile Ile Phe 
    50                  55                  60                  


His Xaa Lys Lys Lys Leu Ser Val Cys Ala Asn Pro Lys Gln Xaa Trp 
65                  70                  75                  80  


Val Lys Tyr Ile Val Arg Leu Leu Ser Lys Lys Val Lys Asn Met 
                85                  90                  95  


<210> 5247
<211> 124
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<400> 5247
Met Ala Gln Ser Leu Ala Leu Ser Leu Leu Ile Leu Val Leu Ala Phe 
1               5                   10                  15      


Gly Ile Pro Arg Xaa Gln Gly Ser Asp Gly Gly Ala Gln Asp Cys Cys 
            20                  25                  30          


Leu Lys Tyr Ser Gln Arg Lys Ile Pro Ala Lys Val Val Arg Ser Tyr 
        35                  40                  45              


Arg Lys Gln Glu Pro Ser Leu Gly Cys Ser Ile Pro Ala Ile Leu Phe 
    50                  55                  60                  


Leu Pro Arg Lys Arg Ser Gln Ala Glu Leu Cys Ala Asp Pro Lys Glu 
65                  70                  75                  80  


Leu Trp Val Gln Gln Leu Met Gln His Leu Asp Lys Xaa Pro Ser Pro 
                85                  90                  95      


Gln Lys Pro Ala Gln Gly Cys Arg Lys Asp Arg Gly Ala Ser Lys Xaa 
            100                 105                 110         


Gly Lys Lys Gly Lys Gly Ser Lys Gly Cys Lys Arg 
        115                 120                 


<210> 5248
<211> 134
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 5248
Met Ala Gln Ser Leu Ala Leu Ser Leu Leu Ile Leu Val Leu Ala Phe 
1               5                   10                  15      


Gly Ile Pro Arg Xaa Gln Gly Ser Asp Gly Gly Ala Gln Asp Cys Cys 
            20                  25                  30          


Leu Lys Tyr Ser Gln Arg Lys Ile Pro Ala Lys Val Val Arg Ser Tyr 
        35                  40                  45              


Arg Lys Gln Glu Pro Ser Leu Gly Cys Ser Ile Pro Ala Ile Leu Phe 
    50                  55                  60                  


Leu Pro Arg Lys Arg Ser Gln Ala Glu Leu Cys Ala Asp Pro Lys Glu 
65                  70                  75                  80  


Leu Trp Val Gln Gln Leu Met Gln His Leu Asp Lys Xaa Pro Ser Pro 
                85                  90                  95      


Gln Lys Pro Ala Gln Gly Cys Arg Lys Asp Arg Gly Ala Ser Lys Xaa 
            100                 105                 110         


Gly Lys Lys Gly Lys Gly Ser Lys Gly Cys Lys Arg Xaa Glu Arg Ser 
        115                 120                 125             


Gln Xaa Pro Lys Gly Pro 
    130                 


<210> 5249
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<400> 5249
Met Asp Arg Leu Gln Xaa Ala Leu Leu Val Val Leu Val Leu Leu Ala 
1               5                   10                  15      


Val Ala Leu Gln Ala Xaa Glu Ala Gly Pro Tyr Gly Ala Asn Met Glu 
            20                  25                  30          


Asp Ser Val Cys Cys Arg Asp Tyr Val Arg Tyr Arg Leu Pro Leu Arg 
        35                  40                  45              


Val Val Lys His Phe Tyr Trp Xaa Ser Asp Ser Cys Pro Arg Pro Gly 
    50                  55                  60                  


Val Val Leu Leu Xaa Phe Arg Asp Lys Glu Ile Cys Ala Asp Pro Arg 
65                  70                  75                  80  


Val Pro Trp Val Lys Met Ile Leu Asn Lys Leu Ser Gln 
                85                  90              


<210> 5250
<211> 13
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<400> 5250
Phe Glu Xaa Asn Ser Glu Cys Ser Lys Pro Gly Val Met 
1               5                   10              


<210> 5251
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<400> 5251
Met Lys Val Ser Val Ala Ala Leu Ser Cys Leu Met Leu Val Xaa Ala 
1               5                   10                  15      


Leu Gly Ser Gln Ala Arg Val Xaa Lys Asp Ala Glu Xaa Glu Phe Met 
            20                  25                  30          


Met Ser Lys Leu Pro Leu Glu Asn Pro Val Leu Leu Asp Met Leu Trp 
        35                  40                  45              


Arg Arg Lys Ile Gly Pro Gln Met Xaa Leu Ser His Ala Ala Gly Phe 
    50                  55                  60                  


His Ala Xaa Ser Ala Asp Cys Cys Ile Ser Tyr Xaa Pro Arg Ser Ile 
65                  70                  75                  80  


Pro Cys Ser Leu Leu Glu Ser Tyr Phe Glu Xaa Asn Ser Glu Cys Ser 
                85                  90                  95      


Lys Pro Gly Val Ile Phe Leu Xaa Lys Lys Gly Arg Arg Phe Cys Ala 
            100                 105                 110         


Asn Pro Ser Asp Lys Gln Val Gln Val Cys Met Arg Met Leu Lys Leu 
        115                 120                 125             


Asp Xaa Arg Ile Lys Xaa Arg Lys Asn 
    130                 135         


<210> 5252
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<400> 5252
Met Lys Val Ser Val Ala Ala Leu Ser Cys Leu Met Leu Val Xaa Ala 
1               5                   10                  15      


Leu Gly Ser Gln Ala Arg Val Xaa Lys Asp Ala Glu Xaa Glu Phe Met 
            20                  25                  30          


Met Ser Lys Leu Pro Leu Glu Asn Pro Val Leu Leu Asp Met Leu Trp 
        35                  40                  45              


Arg Arg Lys Ile Gly Pro Gln Met Xaa Leu Ser His Ala Ala Gly Phe 
    50                  55                  60                  


His Ala Xaa Ser Ala Asp Cys Cys Ile Ser Tyr Xaa Pro Arg Ser Ile 
65                  70                  75                  80  


Pro Cys Ser Leu Leu Glu Ser Tyr Phe Glu Xaa Asn Ser Glu Cys Ser 
                85                  90                  95      


Lys Pro Gly Val Ile Phe Leu Xaa Lys Lys Gly Arg Arg Phe Cys Ala 
            100                 105                 110         


Asn Pro Ser Asp Lys Gln Val Gln Val Cys Val Arg Met Leu Lys Leu 
        115                 120                 125             


Asp Xaa Arg Ile Lys Xaa Arg Lys Asn 
    130                 135         


<210> 5253
<211> 120
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 5253
Met Lys Val Ser Val Ala Ala Leu Ser Cys Leu Met Leu Val Xaa Ala 
1               5                   10                  15      


Leu Gly Ser Gln Ala Arg Val Xaa Lys Asp Ala Glu Xaa Glu Phe Met 
            20                  25                  30          


Met Ser Lys Leu Pro Leu Glu Asn Pro Val Leu Leu Asp Arg Phe His 
        35                  40                  45              


Ala Xaa Ser Ala Asp Cys Cys Ile Ser Tyr Xaa Pro Arg Ser Ile Pro 
    50                  55                  60                  


Cys Ser Leu Leu Glu Ser Tyr Phe Glu Xaa Asn Ser Glu Cys Ser Lys 
65                  70                  75                  80  


Pro Gly Val Ile Phe Leu Xaa Lys Lys Gly Arg Arg Phe Cys Ala Asn 
                85                  90                  95      


Pro Ser Asp Lys Gln Val Gln Val Cys Met Arg Met Leu Lys Leu Asp 
            100                 105                 110         


Xaa Arg Ile Lys Xaa Arg Lys Asn 
        115                 120 


<210> 5254
<211> 120
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 5254
Met Lys Val Ser Val Ala Ala Leu Ser Cys Leu Met Leu Val Xaa Ala 
1               5                   10                  15      


Leu Gly Ser Gln Ala Arg Val Xaa Lys Asp Ala Glu Xaa Glu Phe Met 
            20                  25                  30          


Met Ser Lys Leu Pro Leu Glu Asn Pro Val Leu Leu Asp Arg Phe His 
        35                  40                  45              


Ala Xaa Ser Ala Asp Cys Cys Ile Ser Tyr Xaa Pro Arg Ser Ile Pro 
    50                  55                  60                  


Cys Ser Leu Leu Glu Ser Tyr Phe Glu Xaa Asn Ser Glu Cys Ser Lys 
65                  70                  75                  80  


Pro Gly Val Ile Phe Leu Xaa Lys Lys Gly Arg Arg Phe Cys Ala Asn 
                85                  90                  95      


Pro Ser Asp Lys Gln Val Gln Val Cys Val Arg Met Leu Lys Leu Asp 
            100                 105                 110         


Xaa Arg Ile Lys Xaa Arg Lys Asn 
        115                 120 


<210> 5255
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(118)
<223> Selenocysteine

<400> 5255
Met Ala Gly Leu Met Xaa Ile Val Xaa Ser Leu Leu Phe Leu Gly Val 
1               5                   10                  15      


Cys Ala His His Ile Ile Pro Xaa Gly Ser Val Val Ile Pro Ser Pro 
            20                  25                  30          


Cys Cys Met Phe Phe Val Ser Lys Arg Ile Pro Glu Asn Arg Val Val 
        35                  40                  45              


Ser Tyr Gln Leu Ser Ser Arg Ser Xaa Cys Leu Lys Ala Gly Val Ile 
    50                  55                  60                  


Phe Xaa Xaa Lys Lys Gly Gln Gln Phe Cys Gly Asp Pro Lys Gln Glu 
65                  70                  75                  80  


Trp Val Gln Arg Tyr Met Lys Asn Leu Asp Ala Lys Gln Lys Lys Ala 
                85                  90                  95      


Ser Pro Arg Ala Arg Ala Val Ala Val Lys Gly Pro Val Gln Arg Tyr 
            100                 105                 110         


Pro Gly Asn Gln Xaa Xaa Cys 
        115                 


<210> 5256
<211> 150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<400> 5256
Met Asn Leu Trp Leu Leu Ala Cys Leu Val Ala Gly Phe Leu Gly Ala 
1               5                   10                  15      


Trp Ala Pro Ala Val His Xaa Gln Gly Val Phe Glu Asp Cys Cys Leu 
            20                  25                  30          


Ala Tyr His Tyr Pro Ile Gly Trp Ala Val Leu Arg Arg Ala Trp Xaa 
        35                  40                  45              


Tyr Arg Ile Gln Glu Val Ser Gly Ser Cys Asn Leu Pro Ala Ala Ile 
    50                  55                  60                  


Phe Tyr Leu Pro Lys Arg His Arg Lys Val Cys Gly Asn Pro Lys Ser 
65                  70                  75                  80  


Arg Glu Val Gln Arg Ala Met Lys Leu Leu Asp Ala Arg Asn Lys Val 
                85                  90                  95      


Phe Ala Lys Leu His His Asn Xaa Gln Xaa Phe Gln Ala Gly Pro His 
            100                 105                 110         


Ala Val Lys Lys Leu Ser Ser Gly Asn Ser Lys Leu Ser Ser Ser Lys 
        115                 120                 125             


Phe Ser Asn Pro Ile Ser Ser Ser Lys Arg Asn Val Ser Leu Leu Ile 
    130                 135                 140                 


Ser Ala Asn Ser Gly Lys 
145                 150 


<210> 5257
<211> 150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<400> 5257
Met Asn Leu Trp Leu Leu Ala Cys Leu Val Ala Gly Phe Leu Gly Ala 
1               5                   10                  15      


Trp Ala Pro Ala Val His Xaa Gln Gly Val Phe Glu Asp Cys Cys Leu 
            20                  25                  30          


Ala Tyr His Tyr Pro Ile Gly Trp Ala Val Leu Arg Arg Ala Trp Xaa 
        35                  40                  45              


Tyr Arg Ile Gln Glu Val Ser Gly Ser Cys Asn Leu Pro Ala Ala Ile 
    50                  55                  60                  


Phe Tyr Leu Pro Lys Arg His Arg Lys Val Cys Gly Asn Pro Lys Ser 
65                  70                  75                  80  


Arg Glu Val Gln Arg Ala Met Lys Leu Leu Asp Ala Arg Asn Lys Val 
                85                  90                  95      


Phe Ala Lys Leu His His Asn Xaa Gln Xaa Phe Gln Ala Gly Pro His 
            100                 105                 110         


Ala Val Lys Lys Leu Ser Ser Gly Asn Ser Lys Leu Ser Ser Ser Lys 
        115                 120                 125             


Phe Ser Asn Pro Ile Ser Ser Ser Lys Arg Asn Val Ser Leu Leu Ile 
    130                 135                 140                 


Ser Ala Asn Ser Gly Leu 
145                 150 


<210> 5258
<211> 149
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<400> 5258
Met Asn Leu Trp Leu Leu Ala Cys Leu Val Ala Gly Phe Leu Gly Ala 
1               5                   10                  15      


Trp Ala Pro Ala Val His Xaa Gln Gly Val Phe Glu Asp Cys Cys Leu 
            20                  25                  30          


Ala Tyr His Tyr Pro Ile Gly Trp Ala Val Leu Arg Arg Ala Trp Xaa 
        35                  40                  45              


Tyr Arg Ile Gln Glu Val Ser Gly Ser Cys Asn Leu Pro Ala Ala Ile 
    50                  55                  60                  


Phe Tyr Leu Pro Lys Arg His Arg Lys Val Cys Gly Asn Pro Lys Ser 
65                  70                  75                  80  


Arg Glu Val Gln Arg Ala Met Lys Leu Leu Asp Ala Arg Asn Lys Val 
                85                  90                  95      


Phe Ala Lys Leu His His Asn Xaa Gln Xaa Phe Gln Gly Pro His Ala 
            100                 105                 110         


Val Lys Lys Leu Ser Ser Gly Asn Ser Lys Leu Ser Ser Ser Lys Phe 
        115                 120                 125             


Ser Asn Pro Ile Ser Ser Ser Lys Arg Asn Val Ser Leu Leu Ile Ser 
    130                 135                 140                 


Ala Asn Ser Gly Leu 
145                 


<210> 5259
<211> 84
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<400> 5259
Met Asn Leu Trp Leu Leu Ala Cys Leu Val Ala Gly Phe Leu Gly Ala 
1               5                   10                  15      


Trp Ala Pro Ala Val His Xaa Gln Gly Val Phe Glu Asp Cys Cys Leu 
            20                  25                  30          


Ala Tyr His Tyr Pro Ile Gly Trp Ala Val Leu Arg Arg Ala Trp Xaa 
        35                  40                  45              


Tyr Arg Ile Gln Glu Val Ser Gly Ser Cys Asn Leu Pro Ala Ala Ile 
    50                  55                  60                  


Arg Pro Ser Cys Cys Lys Glu Val Glu Phe Trp Lys Leu Gln Val Ile 
65                  70                  75                  80  


Ile Val Gln Val 
                


<210> 5260
<211> 94
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<400> 5260
Met Met Gly Leu Ser Leu Ala Ser Ala Val Leu Leu Ala Ser Leu Leu 
1               5                   10                  15      


Ser Leu His Leu Gly Xaa Ala Xaa Arg Gly Ser Asp Ile Ser Lys Xaa 
            20                  25                  30          


Cys Cys Phe Gln Tyr Ser His Lys Pro Leu Pro Trp Xaa Trp Val Arg 
        35                  40                  45              


Ser Tyr Glu Phe Xaa Ser Asn Ser Cys Ser Gln Arg Ala Val Ile Phe 
    50                  55                  60                  


Xaa Xaa Lys Arg Gly Lys Lys Val Cys Xaa His Pro Arg Lys Lys Trp 
65                  70                  75                  80  


Val Gln Lys Tyr Ile Ser Leu Leu Lys Xaa Pro Lys Gln Leu 
                85                  90                  


<210> 5261
<211> 112
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<400> 5261
Met Lys Gly Pro Pro Xaa Phe Cys Ser Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Ser Pro Asp Pro Xaa Ala Ala Phe Leu Leu Pro Pro Ser Xaa Ala 
            20                  25                  30          


Cys Cys Xaa Gln Leu Tyr Arg Lys Pro Leu Ser Asp Lys Leu Leu Arg 
        35                  40                  45              


Lys Val Ile Gln Val Glu Leu Gln Glu Ala Asp Gly Asp Cys His Leu 
    50                  55                  60                  


Gln Ala Phe Val Leu His Leu Ala Gln Arg Ser Ile Cys Ile His Pro 
65                  70                  75                  80  


Gln Asn Pro Ser Leu Ser Gln Trp Phe Glu His Gln Glu Arg Lys Leu 
                85                  90                  95      


His Gly Xaa Leu Pro Lys Leu Asn Phe Gly Met Leu Arg Lys Met Gly 
            100                 105                 110         


<210> 5262
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 5262
Met Gln Val Ser Xaa Ala Ala Leu Ala Val Leu Leu Cys Xaa Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Phe Ser Ala Ser Leu Ala Ala Asp Xaa Pro Xaa Ala 
            20                  25                  30          


Cys Cys Phe Ser Tyr Xaa Ser Arg Gln Ile Pro Gln Asn Phe Ile Ala 
        35                  40                  45              


Asp Tyr Phe Glu Xaa Ser Ser Gln Cys Ser Lys Pro Gly Val Ile Phe 
    50                  55                  60                  


Leu Xaa Lys Arg Ser Arg Gln Val Cys Ala Asp Pro Ser Glu Glu Trp 
65                  70                  75                  80  


Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 
                85                  90          


<210> 5263
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<400> 5263
Met Gln Val Ser Xaa Ala Ala Leu Ala Val Leu Leu Cys Xaa Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Xaa Pro Xaa 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Xaa Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Xaa Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Xaa Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 
                85                  90              


<210> 5264
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<400> 5264
Met Lys Leu Cys Val Xaa Val Leu Ser Leu Leu Met Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Pro Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Xaa 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Xaa Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Xaa Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Phe Gln Xaa Lys Arg Ser Lys Gln Val Cys Ala Asp Pro Ser Glu Ser 
65                  70                  75                  80  


Trp Val Gln Glu Tyr Val Tyr Asp Leu Glu Leu Asn 
                85                  90          


<210> 5265
<211> 52
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 5265
Met Lys Leu Cys Val Xaa Val Leu Ser Leu Leu Met Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Pro Ala Leu Ser Ala Pro Asn Ser Lys Pro Lys Glu Ala 
            20                  25                  30          


Ser Lys Ser Val Leu Ile Pro Val Asn Pro Gly Ser Arg Ser Xaa Cys 
        35                  40                  45              


Met Xaa Trp Asn 
    50          


<210> 5266
<211> 47
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<400> 5266
Met Lys Leu Cys Val Xaa Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Lys Ala Ser Lys Ser Ala Leu 
            20                  25                  30          


Xaa Pro Val Ser Pro Gly Ser Arg Ser Xaa Cys Met Xaa Trp Asn 
        35                  40                  45          


<210> 5267
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<400> 5267
Met Lys Leu Cys Val Xaa Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Xaa 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Xaa Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Xaa Ser Ser Leu Cys Ser Gln Pro Ala Val Pro 
    50                  55                  60                  


Trp Asp Ser Asn Leu Gly Lys Gln Val Cys Ala Asp Pro Ser Glu Ser 
65                  70                  75                  80  


Trp Val Gln Glu Tyr Val Tyr Asp Leu Glu Leu Asn 
                85                  90          


<210> 5268
<211> 64
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<400> 5268
Met Lys Leu Cys Val Xaa Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Xaa 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Xaa Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Xaa Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


<210> 5269
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<400> 5269
Met Lys Leu Cys Val Xaa Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Xaa 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Xaa Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Xaa Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Ala Ala Pro Gly Arg Ile Pro Ser Xaa Arg Ala Ala Pro His Gly Pro 
65                  70                  75                  80  


Trp Ser Gly Arg Gly Arg Cys Leu Pro Gln Ala Arg Asp Lys Ala Arg 
                85                  90                  95      


<210> 5270
<211> 86
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<400> 5270
Met Lys Leu Cys Val Xaa Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Xaa 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Xaa Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Xaa Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Ala Ala Pro His Gly Pro Trp Ser Gly Arg Gly Arg Cys Leu Pro Gln 
65                  70                  75                  80  


Ala Arg Asp Lys Ala Arg 
                85      


<210> 5271
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<400> 5271
Met Lys Leu Cys Val Xaa Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Xaa 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Xaa Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Xaa Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Ala Ala Arg Gly Arg Ile Pro Ser Xaa Arg Ala Ala Pro His Gly Pro 
65                  70                  75                  80  


Trp Ser Gly Arg Gly Arg Cys Leu Pro Gln Ala Arg Asp Lys Ala Arg 
                85                  90                  95      


<210> 5272
<211> 103
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(100)
<223> Selenocysteine

<400> 5272
Met Lys Leu Cys Val Xaa Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Xaa 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Xaa Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Xaa Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Glu Trp Lys Leu Gln Gly Val Cys Phe Gln Cys Cys Ser Gly Lys Asp 
65                  70                  75                  80  


Pro Ile His Gln Ser Cys Pro Xaa Trp Xaa Met Val Arg Gln Arg Lys 
                85                  90                  95      


Met Pro Xaa Xaa Gly Lys Gly 
            100             


<210> 5273
<211> 103
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(100)
<223> Selenocysteine

<400> 5273
Met Lys Leu Cys Val Xaa Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Xaa 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Xaa Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Xaa Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Glu Trp Lys Leu Gln Gly Val Cys Phe Gln Cys Cys Ser Arg Lys Asp 
65                  70                  75                  80  


Pro Ile His Gln Ser Cys Pro Xaa Trp Xaa Met Val Arg Gln Arg Lys 
                85                  90                  95      


Met Pro Xaa Xaa Gly Lys Gly 
            100             


<210> 5274
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<400> 5274
Met Lys Leu Cys Val Xaa Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Xaa 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Xaa Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Xaa Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Phe Gln Xaa Lys Arg Gly Lys Gln Val Cys Ala Asp Pro Ser Glu Ser 
65                  70                  75                  80  


Trp Val Gln Glu Tyr Val Tyr Asp Leu Glu Leu Asn 
                85                  90          


<210> 5275
<211> 87
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<400> 5275
Met Lys Leu Cys Val Xaa Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Xaa 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Xaa Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Xaa Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Gly Lys Gln Val Cys Ala Asp Pro Ser Glu Ser Trp Val Gln Glu Tyr 
65                  70                  75                  80  


Val Tyr Asp Leu Glu Leu Asn 
                85          


<210> 5276
<211> 103
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 5276
Met Lys Leu Cys Val Xaa Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Xaa 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Xaa Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Xaa Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Tyr Arg Glu Ser Ala Ser Ser Ala Ala Pro Gly Arg Ile Pro Ser Xaa 
65                  70                  75                  80  


Arg Ala Ala Pro His Gly Pro Trp Ser Gly Arg Gly Arg Cys Leu Pro 
                85                  90                  95      


Gln Ala Arg Asp Lys Ala Arg 
            100             


<210> 5277
<211> 103
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 5277
Met Lys Leu Cys Val Xaa Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Xaa 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Xaa Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Xaa Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Tyr Arg Glu Ser Ala Ser Ser Ala Ala Arg Gly Arg Ile Pro Ser Xaa 
65                  70                  75                  80  


Arg Ala Ala Pro His Gly Pro Trp Ser Gly Arg Gly Arg Cys Leu Pro 
                85                  90                  95      


Gln Ala Arg Asp Lys Ala Arg 
            100             


<210> 5278
<211> 68
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(65)
<223> Selenocysteine

<400> 5278
Met Lys Leu Cys Val Xaa Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Xaa Lys Ser Ser Glu Trp Lys 
            20                  25                  30          


Leu Gln Gly Val Cys Phe Gln Cys Cys Ser Gly Lys Asp Pro Ile His 
        35                  40                  45              


Gln Ser Cys Pro Xaa Trp Xaa Met Val Arg Gln Arg Lys Met Pro Xaa 
    50                  55                  60                  


Xaa Gly Lys Gly 
65              


<210> 5279
<211> 68
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(65)
<223> Selenocysteine

<400> 5279
Met Lys Leu Cys Val Xaa Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Xaa Lys Ser Ser Glu Trp Lys 
            20                  25                  30          


Leu Gln Gly Val Cys Phe Gln Cys Cys Ser Arg Lys Asp Pro Ile His 
        35                  40                  45              


Gln Ser Cys Pro Xaa Trp Xaa Met Val Arg Gln Arg Lys Met Pro Xaa 
    50                  55                  60                  


Xaa Gly Lys Gly 
65              


<210> 5280
<211> 91
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 5280
Met Lys Val Ser Ala Ala Ala Leu Ala Val Ile Leu Ile Ala Xaa Ala 
1               5                   10                  15      


Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Xaa Xaa Pro 
            20                  25                  30          


Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys 
        35                  40                  45              


Glu Tyr Phe Tyr Xaa Ser Gly Lys Cys Ser Asn Pro Ala Val Val Phe 
    50                  55                  60                  


Val Xaa Arg Lys Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp 
65                  70                  75                  80  


Val Arg Glu Tyr Ile Asn Ser Leu Glu Met Ser 
                85                  90      


<210> 5281
<211> 150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<400> 5281
Xaa Ala Ala Leu Ala Val Ile Leu Ile Ala Xaa Ala Leu Cys Ala Pro 
1               5                   10                  15      


Ala Ser Ala Ser Pro Tyr Ser Ser Asp Xaa Xaa Pro Cys Cys Phe Ala 
            20                  25                  30          


Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys Glu Tyr Phe Tyr 
        35                  40                  45              


Xaa Ser Gly Lys Cys Ser Asn Pro Ala Val Val His Arg Ser Arg Met 
    50                  55                  60                  


Pro Lys Arg Glu Gly Gln Gln Val Trp Gln Asp Phe Leu Tyr Asp Ser 
65                  70                  75                  80  


Arg Leu Asn Lys Gly Lys Leu Cys His Pro Lys Glu Pro Pro Ser Val 
                85                  90                  95      


Cys Gln Pro Arg Glu Glu Met Gly Ser Gly Val His Gln Leu Phe Gly 
            100                 105                 110         


Asp Glu Leu Gly Trp Arg Val Leu Glu Pro Glu Leu Xaa Gln Ile Cys 
        115                 120                 125             


Leu Phe Leu Leu Ala Leu Val Leu Ala Trp Glu Ala Ser Pro His Tyr 
    130                 135                 140                 


Pro Xaa Pro Pro Ala Pro 
145                 150 


<210> 5282
<211> 47
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<400> 5282
Met Lys Ala Ser Ala Ala Leu Leu Cys Leu Leu Leu Xaa Ala Ala Ala 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gln Pro Ala Ser Arg Pro Asn Trp Xaa 
            20                  25                  30          


Arg Arg Ser Val Leu Xaa Pro His Arg Ser Gly Ser Arg Xaa Leu 
        35                  40                  45          


<210> 5283
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<400> 5283
Met Lys Ala Ser Ala Ala Leu Leu Cys Leu Leu Leu Xaa Ala Ala Ala 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gln Pro Glu Arg Pro Arg Xaa His Pro 
            20                  25                  30          


Gln Trp Xaa Phe Leu Leu Val Val Ser Leu Gln Leu Gly Leu Ile Leu 
        35                  40                  45              


Gln Leu Pro Ala Ala Xaa Asp Leu Ser Ile Arg Lys Ser Leu Ser Arg 
    50                  55                  60                  


Gly Trp Arg Ala Xaa Glu Gly Pro Pro Val Ala Xaa Val Pro Gly Lys 
65                  70                  75                  80  


Leu 
    


<210> 5284
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<400> 5284
Met Lys Ala Ser Ala Ala Leu Leu Cys Leu Leu Leu Xaa Ala Ala Ala 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gln Pro Val Gly Ile Asn Xaa Ser Xaa 
            20                  25                  30          


Xaa Cys Cys Tyr Arg Phe Ile Asn Lys Lys Ile Pro Lys Gln Arg Leu 
        35                  40                  45              


Glu Ser Tyr Arg Arg Xaa Xaa Ser Ser His Cys Pro Arg Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Xaa Lys Leu Asp Lys Glu Ile Cys Ala Asp Pro Xaa Gln 
65                  70                  75                  80  


Lys Trp Val Gln Asp Phe Met Lys His Leu Asp Lys Lys Xaa Gln Xaa 
                85                  90                  95      


Pro Lys Leu 
            


<210> 5285
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<400> 5285
Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Met Ala Ala Xaa 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gln Pro Asp Ser Val Ser Ile Pro Ile 
            20                  25                  30          


Xaa Cys Cys Phe Asn Val Ile Asn Arg Lys Ile Pro Ile Gln Arg Leu 
        35                  40                  45              


Glu Ser Tyr Xaa Arg Ile Xaa Asn Ile Gln Cys Pro Lys Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Xaa Lys Arg Gly Lys Glu Val Cys Ala Asp Pro Lys Glu 
65                  70                  75                  80  


Arg Trp Val Arg Asp Ser Met Lys His Leu Asp Gln Ile Phe Gln Asn 
                85                  90                  95      


Leu Lys Pro 
            


<210> 5286
<211> 271
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<400> 5286
Met Glu Glu Glu Gly Lys Lys Gly Lys Lys Pro Gly Ile Val Ser Pro 
1               5                   10                  15      


Phe Lys Arg Val Phe Leu Lys Gly Glu Lys Ser Arg Asp Lys Lys Ala 
            20                  25                  30          


His Glu Lys Val Xaa Glu Arg Arg Pro Leu His Xaa Val Val Leu Ser 
        35                  40                  45              


Leu Pro Glu Arg Val Glu Pro Asp Arg Leu Leu Ser Asp Tyr Ile Glu 
    50                  55                  60                  


Lys Glu Val Lys Tyr Leu Gly Gln Leu Xaa Ser Ile Pro Gly Tyr Leu 
65                  70                  75                  80  


Asn Pro Ser Ser Arg Xaa Glu Ile Leu His Phe Ile Asp Asn Ala Lys 
                85                  90                  95      


Arg Ala His Gln Leu Pro Gly His Leu Xaa Gln Glu His Asp Ala Val 
            100                 105                 110         


Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu Ala Trp Arg Asp Gly Glu 
        115                 120                 125             


Asp Ile Ile Leu Arg Val Pro Ile His Asp Ile Ala Ala Val Ser Tyr 
    130                 135                 140                 


Val Arg Asp Asp Ala Ala His Leu Val Val Leu Lys Xaa Ala Gln Asp 
145                 150                 155                 160 


Pro Gly Ile Ser Pro Ser Gln Ser Leu Cys Ala Glu Ser Ser Arg Gly 
                165                 170                 175     


Leu Ser Ala Gly Ser Leu Ser Glu Ser Ala Val Gly Pro Val Glu Ala 
            180                 185                 190         


Cys Cys Leu Val Ile Leu Ala Ala Glu Ser Lys Val Ala Ala Glu Glu 
        195                 200                 205             


Leu Cys Cys Leu Leu Gly Gln Val Phe Gln Val Val Tyr Xaa Glu Ser 
    210                 215                 220                 


Xaa Ile Asp Phe Leu Asp Arg Ala Ile Phe Asp Gly Ala Ser Xaa Pro 
225                 230                 235                 240 


Xaa His His Leu Ser Leu His Ser Ala Ala Ser Leu Asn Leu Trp Met 
                245                 250                 255     


Trp Val Val His His Pro Xaa Ala Arg Pro Ser Val Arg Ala Ser 
            260                 265                 270     


<210> 5287
<211> 444
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<400> 5287
Met Glu Glu Glu Gly Lys Lys Gly Lys Lys Pro Gly Ile Val Ser Pro 
1               5                   10                  15      


Phe Lys Arg Val Phe Leu Lys Gly Glu Lys Ser Arg Asp Lys Lys Ala 
            20                  25                  30          


His Glu Lys Val Xaa Glu Arg Arg Pro Leu His Xaa Val Val Leu Ser 
        35                  40                  45              


Leu Pro Glu Arg Val Glu Pro Asp Arg Leu Leu Ser Asp Tyr Ile Glu 
    50                  55                  60                  


Lys Glu Val Lys Tyr Leu Gly Gln Leu Xaa Ser Ile Pro Gly Tyr Leu 
65                  70                  75                  80  


Asn Pro Ser Ser Arg Xaa Glu Ile Leu His Phe Ile Asp Asn Ala Lys 
                85                  90                  95      


Arg Ala His Gln Leu Pro Gly His Leu Xaa Gln Glu His Asp Ala Val 
            100                 105                 110         


Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu Ala Trp Arg Asp Gly Glu 
        115                 120                 125             


Asp Ile Ile Leu Arg Val Pro Ile His Asp Ile Ala Ala Val Ser Tyr 
    130                 135                 140                 


Val Arg Asp Asp Ala Ala His Leu Val Val Leu Lys Xaa Ala Gln Asp 
145                 150                 155                 160 


Pro Gly Ile Ser Pro Ser Gln Ser Leu Cys Ala Glu Ser Ser Arg Gly 
                165                 170                 175     


Leu Ser Ala Gly Ser Leu Ser Glu Ser Ala Val Gly Pro Val Glu Ala 
            180                 185                 190         


Cys Cys Leu Val Ile Leu Ala Ala Glu Ser Lys Val Ala Ala Glu Glu 
        195                 200                 205             


Leu Cys Cys Leu Leu Gly Gln Val Phe Gln Val Val Tyr Xaa Glu Ser 
    210                 215                 220                 


Xaa Ile Asp Phe Leu Asp Arg Ala Ile Phe Asp Gly Ala Ser Xaa Pro 
225                 230                 235                 240 


Xaa His His Leu Ser Leu His Ser Asp Asp Ser Ser Xaa Lys Val Asp 
                245                 250                 255     


Ile Lys Glu Xaa Tyr Glu Val Glu Ala Ser Xaa Phe Cys Phe Pro Glu 
            260                 265                 270         


Ser Val Asp Val Gly Gly Ala Ser Pro His Ser Lys Xaa Ile Ser Glu 
        275                 280                 285             


Ser Glu Leu Ser Ala Ser Ala Xaa Glu Leu Leu Gln Asp Tyr Met Leu 
    290                 295                 300                 


Xaa Leu Arg Xaa Lys Leu Ser Ser Gln Glu Ile Gln Gln Phe Ala Ala 
305                 310                 315                 320 


Leu Leu His Glu Tyr Arg Asn Gly Ala Ser Ile His Glu Phe Cys Ile 
                325                 330                 335     


Asn Leu Arg Gln Leu Tyr Gly Asp Ser Arg Lys Phe Leu Leu Leu Gly 
            340                 345                 350         


Leu Arg Pro Phe Ile Pro Glu Lys Asp Ser Gln His Phe Glu Asn Phe 
        355                 360                 365             


Leu Glu Xaa Ile Gly Val Lys Asp Gly Arg Gly Ile Ile Xaa Asp Ser 
    370                 375                 380                 


Phe Gly Arg His Arg Arg Ala Leu Ser Xaa Xaa Ser Ser Ser Xaa Xaa 
385                 390                 395                 400 


Asn Gly Asn Arg Ala Xaa Gly Ser Ser Asp Asp Arg Ser Ala Pro Ser 
                405                 410                 415     


Glu Gly Asp Glu Trp Asp Arg Met Ile Ser Asp Ile Ser Ser Asp Ile 
            420                 425                 430         


Glu Ala Leu Gly Cys Ser Met Asp Gln Asp Ser Ala 
        435                 440                 


<210> 5288
<211> 353
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<400> 5288
Met Glu Glu Glu Gly Lys Lys Gly Lys Lys Pro Gly Ile Val Ser Pro 
1               5                   10                  15      


Phe Lys Arg Val Phe Leu Lys Gly Glu Lys Ser Arg Asp Lys Lys Ala 
            20                  25                  30          


His Glu Lys Val Xaa Glu Arg Arg Pro Leu His Xaa Val Val Leu Ser 
        35                  40                  45              


Leu Pro Glu Arg Val Glu Pro Asp Arg Leu Leu Ser Asp Tyr Ile Glu 
    50                  55                  60                  


Lys Glu Val Lys Tyr Leu Gly Gln Leu Xaa Ser Ile Pro Gly Tyr Leu 
65                  70                  75                  80  


Asn Pro Ser Ser Arg Xaa Glu Ile Leu His Phe Ile Asp Asn Ala Lys 
                85                  90                  95      


Arg Ala His Gln Leu Pro Gly His Leu Xaa Gln Glu His Asp Ala Val 
            100                 105                 110         


Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu Ala Trp Arg Asp Gly Glu 
        115                 120                 125             


Asp Ile Ile Leu Arg Val Pro Ile His Asp Ile Ala Ala Val Ser Tyr 
    130                 135                 140                 


Val Arg Asp Asp Ala Ala His Leu Val Val Leu Lys Xaa Asp Asp Ser 
145                 150                 155                 160 


Ser Xaa Lys Val Asp Ile Lys Glu Xaa Tyr Glu Val Glu Ala Ser Xaa 
                165                 170                 175     


Phe Cys Phe Pro Glu Ser Val Asp Val Gly Gly Ala Ser Pro His Ser 
            180                 185                 190         


Lys Xaa Ile Ser Glu Ser Glu Leu Ser Ala Ser Ala Xaa Glu Leu Leu 
        195                 200                 205             


Gln Asp Tyr Met Leu Xaa Leu Arg Xaa Lys Leu Ser Ser Gln Glu Ile 
    210                 215                 220                 


Gln Gln Phe Ala Ala Leu Leu His Glu Tyr Arg Asn Gly Ala Ser Ile 
225                 230                 235                 240 


His Glu Phe Cys Ile Asn Leu Arg Gln Leu Tyr Gly Asp Ser Arg Lys 
                245                 250                 255     


Phe Leu Leu Leu Gly Leu Arg Pro Phe Ile Pro Glu Lys Asp Ser Gln 
            260                 265                 270         


His Phe Glu Asn Phe Leu Glu Xaa Ile Gly Val Lys Asp Gly Arg Gly 
        275                 280                 285             


Ile Ile Xaa Asp Ser Phe Gly Arg His Arg Arg Ala Leu Ser Xaa Xaa 
    290                 295                 300                 


Ser Ser Ser Xaa Xaa Asn Gly Asn Arg Ala Xaa Gly Ser Ser Asp Asp 
305                 310                 315                 320 


Arg Ser Ala Pro Ser Glu Gly Asp Glu Trp Asp Arg Met Ile Ser Asp 
                325                 330                 335     


Ile Ser Ser Asp Ile Glu Ala Leu Gly Cys Ser Met Asp Gln Asp Ser 
            340                 345                 350         


Ala 
    


<210> 5289
<211> 386
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<400> 5289
Met Glu Glu Glu Gly Lys Lys Gly Lys Lys Tyr Leu Gly Gln Leu Xaa 
1               5                   10                  15      


Ser Ile Pro Gly Tyr Leu Asn Pro Ser Ser Arg Xaa Glu Ile Leu His 
            20                  25                  30          


Phe Ile Asp Asn Ala Lys Arg Ala His Gln Leu Pro Gly His Leu Xaa 
        35                  40                  45              


Gln Glu His Asp Ala Val Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu 
    50                  55                  60                  


Ala Trp Arg Asp Gly Glu Asp Ile Ile Leu Arg Val Pro Ile His Asp 
65                  70                  75                  80  


Ile Ala Ala Val Ser Tyr Val Arg Asp Asp Ala Ala His Leu Val Val 
                85                  90                  95      


Leu Lys Xaa Ala Gln Asp Pro Gly Ile Ser Pro Ser Gln Ser Leu Cys 
            100                 105                 110         


Ala Glu Ser Ser Arg Gly Leu Ser Ala Gly Ser Leu Ser Glu Ser Ala 
        115                 120                 125             


Val Gly Pro Val Glu Ala Cys Cys Leu Val Ile Leu Ala Ala Glu Ser 
    130                 135                 140                 


Lys Val Ala Ala Glu Glu Leu Cys Cys Leu Leu Gly Gln Val Phe Gln 
145                 150                 155                 160 


Val Val Tyr Xaa Glu Ser Xaa Ile Asp Phe Leu Asp Arg Ala Ile Phe 
                165                 170                 175     


Asp Gly Ala Ser Xaa Pro Xaa His His Leu Ser Leu His Ser Asp Asp 
            180                 185                 190         


Ser Ser Xaa Lys Val Asp Ile Lys Glu Xaa Tyr Glu Val Glu Ala Ser 
        195                 200                 205             


Xaa Phe Cys Phe Pro Glu Ser Val Asp Val Gly Gly Ala Ser Pro His 
    210                 215                 220                 


Ser Lys Xaa Ile Ser Glu Ser Glu Leu Ser Ala Ser Ala Xaa Glu Leu 
225                 230                 235                 240 


Leu Gln Asp Tyr Met Leu Xaa Leu Arg Xaa Lys Leu Ser Ser Gln Glu 
                245                 250                 255     


Ile Gln Gln Phe Ala Ala Leu Leu His Glu Tyr Arg Asn Gly Ala Ser 
            260                 265                 270         


Ile His Glu Phe Cys Ile Asn Leu Arg Gln Leu Tyr Gly Asp Ser Arg 
        275                 280                 285             


Lys Phe Leu Leu Leu Gly Leu Arg Pro Phe Ile Pro Glu Lys Asp Ser 
    290                 295                 300                 


Gln His Phe Glu Asn Phe Leu Glu Xaa Ile Gly Val Lys Asp Gly Arg 
305                 310                 315                 320 


Gly Ile Ile Xaa Asp Ser Phe Gly Arg His Arg Arg Ala Leu Ser Xaa 
                325                 330                 335     


Xaa Ser Ser Ser Xaa Xaa Asn Gly Asn Arg Ala Xaa Gly Ser Ser Asp 
            340                 345                 350         


Asp Arg Ser Ala Pro Ser Glu Gly Asp Glu Trp Asp Arg Met Ile Ser 
        355                 360                 365             


Asp Ile Ser Ser Asp Ile Glu Ala Leu Gly Cys Ser Met Asp Gln Asp 
    370                 375                 380                 


Ser Ala 
385     


<210> 5290
<211> 438
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<400> 5290
Met Glu Asn Glu Pro Gly Ile Val Ser Pro Phe Lys Arg Val Phe Leu 
1               5                   10                  15      


Lys Gly Glu Lys Ser Arg Asp Lys Lys Ala His Glu Lys Val Xaa Glu 
            20                  25                  30          


Arg Arg Pro Leu His Xaa Val Val Leu Ser Leu Pro Glu Arg Val Glu 
        35                  40                  45              


Pro Asp Arg Leu Leu Ser Asp Tyr Ile Glu Lys Glu Val Lys Tyr Leu 
    50                  55                  60                  


Gly Gln Leu Xaa Ser Ile Pro Gly Tyr Leu Asn Pro Ser Ser Arg Xaa 
65                  70                  75                  80  


Glu Ile Leu His Phe Ile Asp Asn Ala Lys Arg Ala His Gln Leu Pro 
                85                  90                  95      


Gly His Leu Xaa Gln Glu His Asp Ala Val Leu Ser Leu Ser Ala Tyr 
            100                 105                 110         


Asn Val Lys Leu Ala Trp Arg Asp Gly Glu Asp Ile Ile Leu Arg Val 
        115                 120                 125             


Pro Ile His Asp Ile Ala Ala Val Ser Tyr Val Arg Asp Asp Ala Ala 
    130                 135                 140                 


His Leu Val Val Leu Lys Xaa Ala Gln Asp Pro Gly Ile Ser Pro Ser 
145                 150                 155                 160 


Gln Ser Leu Cys Ala Glu Ser Ser Arg Gly Leu Ser Ala Gly Ser Leu 
                165                 170                 175     


Ser Glu Ser Ala Val Gly Pro Val Glu Ala Cys Cys Leu Val Ile Leu 
            180                 185                 190         


Ala Ala Glu Ser Lys Val Ala Ala Glu Glu Leu Cys Cys Leu Leu Gly 
        195                 200                 205             


Gln Val Phe Gln Val Val Tyr Xaa Glu Ser Xaa Ile Asp Phe Leu Asp 
    210                 215                 220                 


Arg Ala Ile Phe Asp Gly Ala Ser Xaa Pro Xaa His His Leu Ser Leu 
225                 230                 235                 240 


His Ser Asp Asp Ser Ser Xaa Lys Val Asp Ile Lys Glu Xaa Tyr Glu 
                245                 250                 255     


Val Glu Ala Ser Xaa Phe Cys Phe Pro Glu Ser Val Asp Val Gly Gly 
            260                 265                 270         


Ala Ser Pro His Ser Lys Xaa Ile Ser Glu Ser Glu Leu Ser Ala Ser 
        275                 280                 285             


Ala Xaa Glu Leu Leu Gln Asp Tyr Met Leu Xaa Leu Arg Xaa Lys Leu 
    290                 295                 300                 


Ser Ser Gln Glu Ile Gln Gln Phe Ala Ala Leu Leu His Glu Tyr Arg 
305                 310                 315                 320 


Asn Gly Ala Ser Ile His Glu Phe Cys Ile Asn Leu Arg Gln Leu Tyr 
                325                 330                 335     


Gly Asp Ser Arg Lys Phe Leu Leu Leu Gly Leu Arg Pro Phe Ile Pro 
            340                 345                 350         


Glu Lys Asp Ser Gln His Phe Glu Asn Phe Leu Glu Xaa Ile Gly Val 
        355                 360                 365             


Lys Asp Gly Arg Gly Ile Ile Xaa Asp Ser Phe Gly Arg His Arg Arg 
    370                 375                 380                 


Ala Leu Ser Xaa Xaa Ser Ser Ser Xaa Xaa Asn Gly Asn Arg Ala Xaa 
385                 390                 395                 400 


Gly Ser Ser Asp Asp Arg Ser Ala Pro Ser Glu Gly Asp Glu Trp Asp 
                405                 410                 415     


Arg Met Ile Ser Asp Ile Ser Ser Asp Ile Glu Ala Leu Gly Cys Ser 
            420                 425                 430         


Met Asp Gln Asp Ser Ala 
        435             


<210> 5291
<211> 347
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<400> 5291
Met Glu Asn Glu Pro Gly Ile Val Ser Pro Phe Lys Arg Val Phe Leu 
1               5                   10                  15      


Lys Gly Glu Lys Ser Arg Asp Lys Lys Ala His Glu Lys Val Xaa Glu 
            20                  25                  30          


Arg Arg Pro Leu His Xaa Val Val Leu Ser Leu Pro Glu Arg Val Glu 
        35                  40                  45              


Pro Asp Arg Leu Leu Ser Asp Tyr Ile Glu Lys Glu Val Lys Tyr Leu 
    50                  55                  60                  


Gly Gln Leu Xaa Ser Ile Pro Gly Tyr Leu Asn Pro Ser Ser Arg Xaa 
65                  70                  75                  80  


Glu Ile Leu His Phe Ile Asp Asn Ala Lys Arg Ala His Gln Leu Pro 
                85                  90                  95      


Gly His Leu Xaa Gln Glu His Asp Ala Val Leu Ser Leu Ser Ala Tyr 
            100                 105                 110         


Asn Val Lys Leu Ala Trp Arg Asp Gly Glu Asp Ile Ile Leu Arg Val 
        115                 120                 125             


Pro Ile His Asp Ile Ala Ala Val Ser Tyr Val Arg Asp Asp Ala Ala 
    130                 135                 140                 


His Leu Val Val Leu Lys Xaa Asp Asp Ser Ser Xaa Lys Val Asp Ile 
145                 150                 155                 160 


Lys Glu Xaa Tyr Glu Val Glu Ala Ser Xaa Phe Cys Phe Pro Glu Ser 
                165                 170                 175     


Val Asp Val Gly Gly Ala Ser Pro His Ser Lys Xaa Ile Ser Glu Ser 
            180                 185                 190         


Glu Leu Ser Ala Ser Ala Xaa Glu Leu Leu Gln Asp Tyr Met Leu Xaa 
        195                 200                 205             


Leu Arg Xaa Lys Leu Ser Ser Gln Glu Ile Gln Gln Phe Ala Ala Leu 
    210                 215                 220                 


Leu His Glu Tyr Arg Asn Gly Ala Ser Ile His Glu Phe Cys Ile Asn 
225                 230                 235                 240 


Leu Arg Gln Leu Tyr Gly Asp Ser Arg Lys Phe Leu Leu Leu Gly Leu 
                245                 250                 255     


Arg Pro Phe Ile Pro Glu Lys Asp Ser Gln His Phe Glu Asn Phe Leu 
            260                 265                 270         


Glu Xaa Ile Gly Val Lys Asp Gly Arg Gly Ile Ile Xaa Asp Ser Phe 
        275                 280                 285             


Gly Arg His Arg Arg Ala Leu Ser Xaa Xaa Ser Ser Ser Xaa Xaa Asn 
    290                 295                 300                 


Gly Asn Arg Ala Xaa Gly Ser Ser Asp Asp Arg Ser Ala Pro Ser Glu 
305                 310                 315                 320 


Gly Asp Glu Trp Asp Arg Met Ile Ser Asp Ile Ser Ser Asp Ile Glu 
                325                 330                 335     


Ala Leu Gly Cys Ser Met Asp Gln Asp Ser Ala 
            340                 345         


<210> 5292
<211> 465
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<400> 5292
Met His Ser Ser Cys Arg Gln Arg Arg Asn Gln Asn Leu Ser Lys Glu 
1               5                   10                  15      


Ile Pro Gln Xaa Glu Phe His Xaa Gly Tyr Ser Met Glu Asn Glu Pro 
            20                  25                  30          


Gly Ile Val Ser Pro Phe Lys Arg Val Phe Leu Lys Gly Glu Lys Ser 
        35                  40                  45              


Arg Asp Lys Lys Ala His Glu Lys Val Xaa Glu Arg Arg Pro Leu His 
    50                  55                  60                  


Xaa Val Val Leu Ser Leu Pro Glu Arg Val Glu Pro Asp Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Tyr Ile Glu Lys Glu Val Lys Tyr Leu Gly Gln Leu Xaa Ser 
                85                  90                  95      


Ile Pro Gly Tyr Leu Asn Pro Ser Ser Arg Xaa Glu Ile Leu His Phe 
            100                 105                 110         


Ile Asp Asn Ala Lys Arg Ala His Gln Leu Pro Gly His Leu Xaa Gln 
        115                 120                 125             


Glu His Asp Ala Val Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu Ala 
    130                 135                 140                 


Trp Arg Asp Gly Glu Asp Ile Ile Leu Arg Val Pro Ile His Asp Ile 
145                 150                 155                 160 


Ala Ala Val Ser Tyr Val Arg Asp Asp Ala Ala His Leu Val Val Leu 
                165                 170                 175     


Lys Xaa Ala Gln Asp Pro Gly Ile Ser Pro Ser Gln Ser Leu Cys Ala 
            180                 185                 190         


Glu Ser Ser Arg Gly Leu Ser Ala Gly Ser Leu Ser Glu Ser Ala Val 
        195                 200                 205             


Gly Pro Val Glu Ala Cys Cys Leu Val Ile Leu Ala Ala Glu Ser Lys 
    210                 215                 220                 


Val Ala Ala Glu Glu Leu Cys Cys Leu Leu Gly Gln Val Phe Gln Val 
225                 230                 235                 240 


Val Tyr Xaa Glu Ser Xaa Ile Asp Phe Leu Asp Arg Ala Ile Phe Asp 
                245                 250                 255     


Gly Ala Ser Xaa Pro Xaa His His Leu Ser Leu His Ser Asp Asp Ser 
            260                 265                 270         


Ser Xaa Lys Val Asp Ile Lys Glu Xaa Tyr Glu Val Glu Ala Ser Xaa 
        275                 280                 285             


Phe Cys Phe Pro Glu Ser Val Asp Val Gly Gly Ala Ser Pro His Ser 
    290                 295                 300                 


Lys Xaa Ile Ser Glu Ser Glu Leu Ser Ala Ser Ala Xaa Glu Leu Leu 
305                 310                 315                 320 


Gln Asp Tyr Met Leu Xaa Leu Arg Xaa Lys Leu Ser Ser Gln Glu Ile 
                325                 330                 335     


Gln Gln Phe Ala Ala Leu Leu His Glu Tyr Arg Asn Gly Ala Ser Ile 
            340                 345                 350         


His Glu Phe Cys Ile Asn Leu Arg Gln Leu Tyr Gly Asp Ser Arg Lys 
        355                 360                 365             


Phe Leu Leu Leu Gly Leu Arg Pro Phe Ile Pro Glu Lys Asp Ser Gln 
    370                 375                 380                 


His Phe Glu Asn Phe Leu Glu Xaa Ile Gly Val Lys Asp Gly Arg Gly 
385                 390                 395                 400 


Ile Ile Xaa Asp Ser Phe Gly Arg His Arg Arg Ala Leu Ser Xaa Xaa 
                405                 410                 415     


Ser Ser Ser Xaa Xaa Asn Gly Asn Arg Ala Xaa Gly Ser Ser Asp Asp 
            420                 425                 430         


Arg Ser Ala Pro Ser Glu Gly Asp Glu Trp Asp Arg Met Ile Ser Asp 
        435                 440                 445             


Ile Ser Ser Asp Ile Glu Ala Leu Gly Cys Ser Met Asp Gln Asp Ser 
    450                 455                 460                 


Ala 
465 


<210> 5293
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<400> 5293
Xaa Gly Leu Ser Ala Gly Ser Leu Ser Glu Ser Ala Val Gly Pro Val 
1               5                   10                  15      


Glu Ala Cys Cys Leu Val Ile Leu Ala Ala Glu Ser Lys Val Ala Ala 
            20                  25                  30          


Glu Glu Leu Cys Cys Leu Leu Gly Gln Val Phe Gln Val Val Tyr Xaa 
        35                  40                  45              


Glu Ser Xaa Ile Asp Phe Leu Asp Arg Ala Ile Phe Asp Gly Ala Ser 
    50                  55                  60                  


Xaa Pro Xaa His His Leu Ser Leu His Ser Ala Ser His Val Xaa Ser 
65                  70                  75                  80  


Ser Xaa Val Xaa Ser Ser Phe Asp Cys Gln Leu Pro Leu His Phe Arg 
                85                  90                  95      


Xaa Leu Ala Ile Xaa Leu Ser Pro Pro Lys Phe Ser Arg Val Ile Ser 
            100                 105                 110         


Leu Phe Gln Asp Asp Ser Ser Xaa Lys Val Asp Ile Lys Glu Xaa Tyr 
        115                 120                 125             


Glu Val Glu Ala Ser Xaa Leu 
    130                 135 


<210> 5294
<211> 432
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<400> 5294
Met Leu Gly Asn Ser Ala Pro Gly Pro Ala Xaa Arg Glu Ala Gly Ser 
1               5                   10                  15      


Ala Leu Leu Ala Leu Gln Gln Xaa Ala Leu Gln Glu Asp Gln Glu Asn 
            20                  25                  30          


Ile Asn Pro Glu Lys Ala Ala Pro Val Gln Gln Pro Arg Xaa Arg Ala 
        35                  40                  45              


Ala Leu Ala Val Leu Lys Ser Gly Asn Pro Arg Gly Leu Ala Gln Gln 
    50                  55                  60                  


Gln Arg Pro Lys Xaa Arg Arg Val Ala Pro Leu Lys Asp Leu Pro Val 
65                  70                  75                  80  


Asn Asp Glu His Val Xaa Val Pro Pro Trp Lys Ala Asn Ser Lys Gln 
                85                  90                  95      


Pro Ala Phe Xaa Ile His Val Asp Glu Ala Glu Lys Glu Ala Gln Lys 
            100                 105                 110         


Lys Pro Ala Glu Ser Gln Lys Ile Glu Arg Glu Asp Ala Leu Ala Phe 
        115                 120                 125             


Asn Ser Ala Ile Ser Leu Pro Gly Pro Arg Lys Pro Leu Val Pro Leu 
    130                 135                 140                 


Asp Tyr Pro Met Asp Gly Ser Phe Glu Ser Pro His Xaa Met Asp Met 
145                 150                 155                 160 


Ser Ile Ile Leu Glu Asp Glu Lys Pro Val Ser Val Asn Glu Val Pro 
                165                 170                 175     


Asp Tyr His Glu Asp Ile His Xaa Tyr Leu Arg Glu Met Glu Val Lys 
            180                 185                 190         


Cys Lys Pro Lys Val Gly Tyr Met Lys Lys Gln Pro Asp Ile Xaa Asn 
        195                 200                 205             


Ser Met Arg Ala Ile Leu Val Asp Trp Leu Val Glu Val Gly Glu Glu 
    210                 215                 220                 


Tyr Lys Leu Gln Asn Glu Xaa Leu His Leu Ala Val Asn Tyr Ile Asp 
225                 230                 235                 240 


Arg Phe Leu Ser Ser Met Ser Val Leu Arg Gly Lys Leu Gln Leu Val 
                245                 250                 255     


Gly Xaa Ala Ala Met Leu Leu Ala Ser Lys Phe Glu Glu Ile Tyr Pro 
            260                 265                 270         


Pro Glu Val Ala Glu Phe Val Tyr Ile Xaa Asp Asp Xaa Tyr Xaa Lys 
        275                 280                 285             


Lys Gln Val Leu Arg Met Glu His Leu Val Leu Lys Val Leu Xaa Phe 
    290                 295                 300                 


Asp Leu Ala Ala Pro Xaa Val Asn Gln Phe Leu Xaa Gln Tyr Phe Leu 
305                 310                 315                 320 


His Gln Gln Pro Ala Asn Cys Lys Val Glu Ser Leu Ala Met Phe Leu 
                325                 330                 335     


Gly Glu Leu Ser Leu Ile Asp Ala Asp Pro Tyr Leu Lys Tyr Leu Pro 
            340                 345                 350         


Ser Val Ile Ala Gly Ala Ala Phe His Leu Ala Leu Tyr Xaa Val Xaa 
        355                 360                 365             


Gly Gln Ser Trp Pro Glu Ser Leu Ile Arg Lys Xaa Gly Tyr Xaa Leu 
    370                 375                 380                 


Glu Ser Leu Lys Pro Cys Leu Met Asp Leu His Gln Xaa Tyr Leu Lys 
385                 390                 395                 400 


Ala Pro Gln His Ala Gln Gln Ser Ile Arg Glu Lys Tyr Lys Asn Ser 
                405                 410                 415     


Lys Tyr His Gly Val Ser Leu Leu Asn Pro Pro Glu Xaa Leu Asn Leu 
            420                 425                 430         


<210> 5295
<211> 61
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<400> 5295
Ala Leu Arg Val Xaa Arg Val Ser Arg Phe Gly Leu Arg Xaa Asn Ala 
1               5                   10                  15      


Ala Phe Leu Ala Ala Ala Cys Ser Pro Cys Leu Ala Cys Gly Ser Leu 
            20                  25                  30          


Pro Ser Gly Arg Gly Pro Gln Glu Arg Phe Gly Glu Glu Gly Gly Arg 
        35                  40                  45              


Gly Leu Xaa Lys Arg Ala Pro Arg Trp Ala Gln Ala Trp 
    50                  55                  60      


<210> 5296
<211> 396
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<400> 5296
Met Ala Leu Arg Val Xaa Arg Asn Ser Lys Ile Asn Ala Glu Asn Lys 
1               5                   10                  15      


Ala Lys Ile Asn Met Ala Gly Ala Lys Arg Val Pro Xaa Ala Pro Ala 
            20                  25                  30          


Ala Xaa Ser Lys Pro Gly Leu Arg Pro Arg Xaa Ala Leu Gly Asp Ile 
        35                  40                  45              


Gly Asn Lys Val Ser Glu Gln Leu Gln Ala Lys Met Pro Met Lys Lys 
    50                  55                  60                  


Glu Ala Lys Pro Ser Ala Xaa Gly Lys Val Ile Asp Lys Lys Leu Pro 
65                  70                  75                  80  


Lys Pro Leu Glu Lys Val Pro Met Leu Val Pro Val Pro Val Ser Glu 
                85                  90                  95      


Pro Val Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Val Lys Glu 
            100                 105                 110         


Glu Lys Leu Ser Pro Glu Pro Ile Leu Val Asp Xaa Ala Ser Pro Ser 
        115                 120                 125             


Pro Met Glu Xaa Ser Gly Cys Ala Pro Ala Glu Glu Asp Leu Cys Gln 
    130                 135                 140                 


Ala Phe Ser Asp Val Ile Leu Ala Val Asn Asp Val Asp Ala Glu Asp 
145                 150                 155                 160 


Gly Ala Asp Pro Asn Leu Cys Ser Glu Tyr Val Lys Asp Ile Tyr Ala 
                165                 170                 175     


Tyr Leu Arg Gln Leu Glu Glu Glu Gln Ala Val Arg Pro Lys Tyr Leu 
            180                 185                 190         


Leu Gly Arg Glu Val Xaa Gly Asn Met Arg Ala Ile Leu Ile Asp Trp 
        195                 200                 205             


Leu Val Gln Val Gln Met Lys Phe Arg Leu Leu Gln Glu Xaa Met Tyr 
    210                 215                 220                 


Met Xaa Val Ser Ile Ile Asp Arg Phe Met Gln Asn Asn Cys Val Pro 
225                 230                 235                 240 


Lys Lys Met Leu Gln Leu Val Gly Val Xaa Ala Met Phe Ile Ala Ser 
                245                 250                 255     


Lys Tyr Glu Glu Met Tyr Pro Pro Glu Ile Gly Asp Phe Ala Phe Val 
            260                 265                 270         


Xaa Asp Asn Xaa Tyr Xaa Lys His Gln Ile Arg Gln Met Glu Met Lys 
        275                 280                 285             


Ile Leu Arg Ala Leu Asn Phe Gly Leu Gly Arg Pro Leu Pro Leu His 
    290                 295                 300                 


Phe Leu Arg Arg Ala Ser Lys Ile Gly Glu Val Asp Val Glu Gln His 
305                 310                 315                 320 


Xaa Leu Ala Lys Tyr Leu Met Glu Leu Xaa Met Leu Asp Tyr Asp Met 
                325                 330                 335     


Val His Phe Pro Pro Ser Gln Ile Ala Ala Gly Ala Phe Cys Leu Ala 
            340                 345                 350         


Leu Lys Ile Leu Asp Asn Gly Glu Trp Xaa Val Lys Asn Lys Tyr Ala 
        355                 360                 365             


Xaa Ser Lys His Ala Lys Ile Ser Xaa Leu Pro Gln Leu Asn Ser Ala 
    370                 375                 380                 


Leu Val Gln Asp Leu Ala Lys Ala Val Ala Lys Val 
385                 390                 395     


<210> 5297
<211> 401
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<400> 5297
Met Ala Leu Arg Val Xaa Arg Asn Ser Lys Ile Asn Ala Glu Asn Lys 
1               5                   10                  15      


Ala Lys Ile Asn Met Ala Gly Ala Lys Arg Val Pro Xaa Ala Pro Ala 
            20                  25                  30          


Ala Xaa Ser Lys Pro Gly Leu Arg Pro Arg Xaa Ala Leu Gly Asp Ile 
        35                  40                  45              


Gly Asn Lys Val Ser Glu Gln Leu Gln Ala Lys Met Pro Met Lys Lys 
    50                  55                  60                  


Glu Ala Lys Pro Ser Ala Xaa Gly Lys Val Ile Asp Lys Lys Leu Pro 
65                  70                  75                  80  


Lys Pro Leu Glu Lys Val Pro Met Leu Val Pro Val Pro Val Ser Glu 
                85                  90                  95      


Pro Val Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Val Lys Glu 
            100                 105                 110         


Glu Lys Leu Ser Pro Glu Pro Ile Leu Val Asp Xaa Ala Ser Pro Ser 
        115                 120                 125             


Pro Met Glu Xaa Ser Gly Cys Ala Pro Ala Glu Glu Asp Leu Cys Gln 
    130                 135                 140                 


Ala Phe Ser Asp Val Ile Leu Ala Val Asn Asp Val Asp Ala Glu Asp 
145                 150                 155                 160 


Gly Ala Asp Pro Asn Leu Cys Ser Glu Tyr Val Lys Asp Ile Tyr Ala 
                165                 170                 175     


Tyr Leu Arg Gln Leu Glu Glu Glu Gln Ala Val Arg Pro Lys Tyr Leu 
            180                 185                 190         


Leu Gly Arg Glu Val Xaa Gly Asn Met Arg Ala Ile Leu Ile Asp Trp 
        195                 200                 205             


Leu Val Gln Val Gln Met Lys Phe Arg Leu Leu Gln Glu Xaa Met Tyr 
    210                 215                 220                 


Met Xaa Val Ser Ile Ile Asp Arg Phe Met Gln Asn Asn Cys Val Pro 
225                 230                 235                 240 


Lys Lys Met Leu Gln Leu Val Gly Val Xaa Ala Met Phe Ile Ala Ser 
                245                 250                 255     


Lys Tyr Glu Glu Met Tyr Pro Pro Glu Ile Gly Asp Phe Ala Phe Val 
            260                 265                 270         


Xaa Asp Asn Xaa Tyr Xaa Lys His Gln Ile Arg Gln Met Glu Met Lys 
        275                 280                 285             


Ile Leu Arg Ala Leu Asn Phe Gly Leu Gly Arg Pro Leu Pro Leu His 
    290                 295                 300                 


Phe Leu Arg Arg Ala Ser Lys Ile Gly Glu Val Asp Val Glu Gln His 
305                 310                 315                 320 


Xaa Leu Ala Lys Tyr Leu Met Glu Leu Xaa Met Leu Asp Tyr Asp Met 
                325                 330                 335     


Val His Phe Pro Pro Ser Gln Ile Ala Ala Gly Ala Phe Cys Leu Ala 
            340                 345                 350         


Leu Lys Ile Leu Asp Asn Gly Glu Trp Xaa Pro Xaa Leu Gln His Tyr 
        355                 360                 365             


Leu Ser Tyr Xaa Glu Glu Ser Leu Leu Pro Val Met Gln His Leu Ala 
    370                 375                 380                 


Lys Asn Val Val Met Val Asn Gln Gly Leu Xaa Lys His Met Val Ser 
385                 390                 395                 400 


Gln 
    


<210> 5298
<211> 433
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<400> 5298
Met Ala Leu Arg Val Xaa Arg Asn Ser Lys Ile Asn Ala Glu Asn Lys 
1               5                   10                  15      


Ala Lys Ile Asn Met Ala Gly Ala Lys Arg Val Pro Xaa Ala Pro Ala 
            20                  25                  30          


Ala Xaa Ser Lys Pro Gly Leu Arg Pro Arg Xaa Ala Leu Gly Asp Ile 
        35                  40                  45              


Gly Asn Lys Val Ser Glu Gln Leu Gln Ala Lys Met Pro Met Lys Lys 
    50                  55                  60                  


Glu Ala Lys Pro Ser Ala Xaa Gly Lys Val Ile Asp Lys Lys Leu Pro 
65                  70                  75                  80  


Lys Pro Leu Glu Lys Val Pro Met Leu Val Pro Val Pro Val Ser Glu 
                85                  90                  95      


Pro Val Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Val Lys Glu 
            100                 105                 110         


Glu Lys Leu Ser Pro Glu Pro Ile Leu Val Asp Xaa Ala Ser Pro Ser 
        115                 120                 125             


Pro Met Glu Xaa Ser Gly Cys Ala Pro Ala Glu Glu Asp Leu Cys Gln 
    130                 135                 140                 


Ala Phe Ser Asp Val Ile Leu Ala Val Asn Asp Val Asp Ala Glu Asp 
145                 150                 155                 160 


Gly Ala Asp Pro Asn Leu Cys Ser Glu Tyr Val Lys Asp Ile Tyr Ala 
                165                 170                 175     


Tyr Leu Arg Gln Leu Glu Glu Glu Gln Ala Val Arg Pro Lys Tyr Leu 
            180                 185                 190         


Leu Gly Arg Glu Val Xaa Gly Asn Met Arg Ala Ile Leu Ile Asp Trp 
        195                 200                 205             


Leu Val Gln Val Gln Met Lys Phe Arg Leu Leu Gln Glu Xaa Met Tyr 
    210                 215                 220                 


Met Xaa Val Ser Ile Ile Asp Arg Phe Met Gln Asn Asn Cys Val Pro 
225                 230                 235                 240 


Lys Lys Met Leu Gln Leu Val Gly Val Xaa Ala Met Phe Ile Ala Ser 
                245                 250                 255     


Lys Tyr Glu Glu Met Tyr Pro Pro Glu Ile Gly Asp Phe Ala Phe Val 
            260                 265                 270         


Xaa Asp Asn Xaa Tyr Xaa Lys His Gln Ile Arg Gln Met Glu Met Lys 
        275                 280                 285             


Ile Leu Arg Ala Leu Asn Phe Gly Leu Gly Arg Pro Leu Pro Leu His 
    290                 295                 300                 


Phe Leu Arg Arg Ala Ser Lys Ile Gly Glu Val Asp Val Glu Gln His 
305                 310                 315                 320 


Xaa Leu Ala Lys Tyr Leu Met Glu Leu Xaa Met Leu Asp Tyr Asp Met 
                325                 330                 335     


Val His Phe Pro Pro Ser Gln Ile Ala Ala Gly Ala Phe Cys Leu Ala 
            340                 345                 350         


Leu Lys Ile Leu Asp Asn Gly Glu Trp Xaa Pro Xaa Leu Gln His Tyr 
        355                 360                 365             


Leu Ser Tyr Xaa Glu Glu Ser Leu Leu Pro Val Met Gln His Leu Ala 
    370                 375                 380                 


Lys Asn Val Val Met Val Asn Gln Gly Leu Xaa Lys His Met Xaa Val 
385                 390                 395                 400 


Lys Asn Lys Tyr Ala Xaa Ser Lys His Ala Lys Ile Ser Xaa Leu Pro 
                405                 410                 415     


Gln Leu Asn Ser Ala Leu Val Gln Asp Leu Ala Lys Ala Val Ala Lys 
            420                 425                 430         


Val 
    


<210> 5299
<211> 244
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<400> 5299
Met Ala Leu Arg Val Xaa Arg Asn Ser Lys Ile Asn Ala Glu Asn Lys 
1               5                   10                  15      


Ala Lys Ile Asn Met Ala Gly Ala Lys Arg Val Pro Xaa Ala Pro Ala 
            20                  25                  30          


Ala Xaa Ser Lys Pro Gly Leu Arg Pro Arg Xaa Ala Leu Gly Asp Ile 
        35                  40                  45              


Gly Asn Lys Val Ser Glu Gln Leu Gln Ala Lys Met Pro Met Lys Lys 
    50                  55                  60                  


Glu Ala Lys Pro Ser Ala Xaa Gly Lys Val Ile Asp Lys Lys Leu Pro 
65                  70                  75                  80  


Lys Pro Leu Glu Lys Val Pro Met Leu Val Pro Val Pro Val Ser Glu 
                85                  90                  95      


Pro Val Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Val Lys Glu 
            100                 105                 110         


Glu Lys Leu Ser Pro Glu Pro Ile Leu Val Asp Xaa Ala Ser Pro Ser 
        115                 120                 125             


Pro Met Glu Xaa Ser Gly Cys Ala Pro Ala Glu Glu Asp Leu Cys Gln 
    130                 135                 140                 


Ala Phe Ser Asp Val Ile Leu Ala Val Asn Asp Val Asp Ala Glu Asp 
145                 150                 155                 160 


Gly Ala Asp Pro Asn Leu Cys Ser Glu Tyr Val Lys Asp Ile Tyr Ala 
                165                 170                 175     


Tyr Leu Arg Gln Leu Glu Asn Asn Cys Val Pro Lys Lys Met Leu Gln 
            180                 185                 190         


Leu Val Gly Val Xaa Ala Met Phe Ile Ala Ser Lys Tyr Glu Glu Met 
        195                 200                 205             


Tyr Pro Pro Glu Ile Gly Asp Phe Ala Phe Val Xaa Asp Asn Xaa Tyr 
    210                 215                 220                 


Xaa Lys His Gln Ile Arg Gln Met Glu Met Lys Ile Leu Arg Ala Leu 
225                 230                 235                 240 


Asn Phe Gly Leu 
                


<210> 5300
<211> 185
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<400> 5300
Gln Ala Val Arg Pro Lys Tyr Leu Leu Gly Arg Glu Val Xaa Gly Asn 
1               5                   10                  15      


Met Arg Ala Ile Leu Ile Asp Trp Leu Val Gln Val Gln Met Lys Phe 
            20                  25                  30          


Arg Leu Leu Gln Glu Xaa Met Tyr Met Xaa Val Ser Ile Ile Asp Arg 
        35                  40                  45              


Phe Met Gln Asn Asn Cys Val Pro Lys Lys Met Leu Gln Leu Val Gly 
    50                  55                  60                  


Val Xaa Ala Met Phe Ile Ala Ser Lys Tyr Glu Glu Met Tyr Pro Pro 
65                  70                  75                  80  


Glu Ile Gly Asp Phe Ala Phe Val Xaa Asp Asn Xaa Tyr Xaa Lys His 
                85                  90                  95      


Gln Ile Arg Gln Met Glu Met Lys Ile Leu Arg Ala Leu Asn Phe Gly 
            100                 105                 110         


Leu Gly Arg Pro Leu Pro Leu His Phe Leu Arg Arg Ala Ser Lys Ile 
        115                 120                 125             


Gly Glu Val Asp Val Glu Gln His Xaa Leu Ala Lys Tyr Leu Met Glu 
    130                 135                 140                 


Leu Xaa Met Leu Asp Tyr Asp Met Val His Phe Pro Pro Ser Gln Ile 
145                 150                 155                 160 


Ala Ala Gly Ala Phe Cys Leu Ala Leu Lys Ile Leu Asp Asn Gly Glu 
                165                 170                 175     


Trp Leu Cys Ser Xaa Trp Leu Arg Met 
            180                 185 


<210> 5301
<211> 67
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<400> 5301
Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Xaa Ile Arg Arg Ala 
1               5                   10                  15      


Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
            20                  25                  30          


Lys Ala Glu Glu Xaa Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
        35                  40                  45              


Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Xaa Trp Met 
    50                  55                  60                  


Leu Glu Met 
65          


<210> 5302
<211> 295
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<400> 5302
Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Xaa Ile Arg Arg Ala 
1               5                   10                  15      


Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
            20                  25                  30          


Lys Ala Glu Glu Xaa Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
        35                  40                  45              


Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Xaa Trp Met 
    50                  55                  60                  


Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
65                  70                  75                  80  


Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys 
                85                  90                  95      


Ser Arg Leu Gln Leu Leu Gly Ala Xaa Cys Met Phe Val Ala Ser Lys 
            100                 105                 110         


Met Lys Glu Xaa Ile Pro Leu Xaa Ala Glu Lys Leu Cys Ile Tyr Xaa 
        115                 120                 125             


Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
    130                 135                 140                 


Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Xaa Pro His Asp Phe 
145                 150                 155                 160 


Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln 
                165                 170                 175     


Ile Ile Arg Lys His Ala Gln Xaa Phe Val Ala Leu Cys Ala Xaa Asp 
            180                 185                 190         


Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
        195                 200                 205             


Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu 
    210                 215                 220                 


Ser Tyr Tyr Arg Leu Xaa Arg Phe Leu Ser Arg Val Ile Lys Cys Asp 
225                 230                 235                 240 


Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                245                 250                 255     


Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu 
            260                 265                 270         


Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Xaa Pro Xaa 
        275                 280                 285             


Asp Val Arg Asp Val Asp Ile 
    290                 295 


<210> 5303
<211> 220
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<400> 5303
Met Glu Leu Leu Cys Cys Glu Gly Xaa Arg His Ala Pro Arg Ala Gly 
1               5                   10                  15      


Pro Asp Pro Arg Leu Leu Gly Asp Gln Arg Val Leu Gln Ser Leu Leu 
            20                  25                  30          


Arg Leu Glu Glu Arg Tyr Val Pro Arg Ala Ser Tyr Phe Gln Cys Val 
        35                  40                  45              


Gln Arg Glu Ile Lys Pro His Met Arg Lys Met Leu Ala Tyr Trp Met 
    50                  55                  60                  


Leu Glu Asp Trp Glu Val Leu Val Leu Gly Lys Leu Lys Trp Asp Leu 
65                  70                  75                  80  


Ala Ala Val Ile Ala His Asp Phe Leu Ala Phe Ile Leu His Arg Leu 
                85                  90                  95      


Ser Leu Pro Arg Asp Arg Gln Ala Leu Val Lys Lys His Ala Gln Xaa 
            100                 105                 110         


Phe Leu Ala Leu Cys Ala Xaa Asp Tyr Xaa Phe Ala Met Tyr Pro Pro 
        115                 120                 125             


Ser Met Ile Ala Xaa Gly Ser Ile Gly Ala Ala Val Gln Gly Leu Gly 
    130                 135                 140                 


Ala Cys Ser Met Ser Gly Asp Glu Leu Xaa Glu Leu Leu Ala Gly Ile 
145                 150                 155                 160 


Xaa Gly Xaa Glu Val Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu 
                165                 170                 175     


Ala Ala Leu Arg Glu Ser Leu Arg Glu Ala Ser Gln Xaa Ser Ser Ser 
            180                 185                 190         


Pro Ala Pro Lys Ala Pro Arg Gly Ser Ser Ser Gln Gly Pro Ser Gln 
        195                 200                 205             


Xaa Ser Xaa Pro Xaa Asp Val Xaa Ala Ile His Leu 
    210                 215                 220 


<210> 5304
<211> 292
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<400> 5304
Met Glu Leu Leu Cys Cys Glu Gly Xaa Arg His Ala Pro Arg Ala Gly 
1               5                   10                  15      


Pro Asp Pro Arg Leu Leu Gly Asp Gln Arg Val Leu Gln Ser Leu Leu 
            20                  25                  30          


Arg Leu Glu Glu Arg Tyr Val Pro Arg Ala Ser Tyr Phe Gln Cys Val 
        35                  40                  45              


Gln Arg Glu Ile Lys Pro His Met Arg Lys Met Leu Ala Tyr Trp Met 
    50                  55                  60                  


Leu Glu Val Cys Glu Glu Gln Arg Cys Glu Glu Glu Val Phe Pro Leu 
65                  70                  75                  80  


Ala Met Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Xaa Arg Lys 
                85                  90                  95      


Ala Gln Leu Gln Leu Leu Gly Ala Val Cys Met Leu Leu Ala Ser Lys 
            100                 105                 110         


Leu Arg Glu Xaa Xaa Pro Leu Xaa Ile Glu Lys Leu Cys Ile Tyr Xaa 
        115                 120                 125             


Asp His Ala Val Ser Pro Arg Gln Leu Arg Asp Trp Glu Val Leu Val 
    130                 135                 140                 


Leu Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe 
145                 150                 155                 160 


Leu Ala Phe Ile Leu His Arg Leu Ser Leu Pro Arg Asp Arg Gln Ala 
                165                 170                 175     


Leu Val Lys Lys His Ala Gln Xaa Phe Leu Ala Leu Cys Ala Xaa Asp 
            180                 185                 190         


Tyr Xaa Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Xaa Gly Ser Ile 
        195                 200                 205             


Gly Ala Ala Val Gln Gly Leu Gly Ala Cys Ser Met Ser Gly Asp Glu 
    210                 215                 220                 


Leu Xaa Glu Leu Leu Ala Gly Ile Xaa Gly Xaa Glu Val Asp Cys Leu 
225                 230                 235                 240 


Arg Ala Cys Gln Glu Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu Arg 
                245                 250                 255     


Glu Ala Ser Gln Xaa Ser Ser Ser Pro Ala Pro Lys Ala Pro Arg Gly 
            260                 265                 270         


Ser Ser Ser Gln Gly Pro Ser Gln Xaa Ser Xaa Pro Xaa Asp Val Xaa 
        275                 280                 285             


Ala Ile His Leu 
    290         


<210> 5305
<211> 47
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<400> 5305
Met Lys Ser Ala Gly Gly Ser Gly Arg Ser Leu Leu Pro Ser Pro Arg 
1               5                   10                  15      


Val Cys Glu Glu Gln Arg Cys Glu Glu Glu Val Phe Pro Leu Ala Met 
            20                  25                  30          


Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Xaa Arg Lys Ala 
        35                  40                  45          


<210> 5306
<211> 242
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<400> 5306
Met Lys Ser Ala Gly Gly Ser Gly Arg Ser Leu Leu Pro Ser Pro Arg 
1               5                   10                  15      


Val Cys Glu Glu Gln Arg Cys Glu Glu Glu Val Phe Pro Leu Ala Met 
            20                  25                  30          


Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Xaa Arg Lys Ala Gln 
        35                  40                  45              


Leu Gln Leu Leu Gly Ala Val Cys Met Leu Leu Ala Ser Lys Leu Arg 
    50                  55                  60                  


Glu Xaa Xaa Pro Leu Xaa Ile Glu Lys Leu Cys Ile Tyr Xaa Asp His 
65                  70                  75                  80  


Ala Val Ser Pro Arg Gln Leu Arg Asp Trp Glu Val Leu Val Leu Gly 
                85                  90                  95      


Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe Leu Ala 
            100                 105                 110         


Phe Ile Leu His Arg Leu Ser Leu Pro Arg Asp Arg Gln Ala Leu Val 
        115                 120                 125             


Lys Lys His Ala Gln Xaa Phe Leu Ala Leu Cys Ala Xaa Asp Tyr Xaa 
    130                 135                 140                 


Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Xaa Gly Ser Ile Gly Ala 
145                 150                 155                 160 


Ala Val Gln Gly Leu Gly Ala Cys Ser Met Ser Gly Asp Glu Leu Xaa 
                165                 170                 175     


Glu Leu Leu Ala Gly Ile Xaa Gly Xaa Glu Val Asp Cys Leu Arg Ala 
            180                 185                 190         


Cys Gln Glu Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu Arg Glu Ala 
        195                 200                 205             


Ser Gln Xaa Ser Ser Ser Pro Ala Pro Lys Ala Pro Arg Gly Ser Ser 
    210                 215                 220                 


Ser Gln Gly Pro Ser Gln Xaa Ser Xaa Pro Xaa Asp Val Xaa Ala Ile 
225                 230                 235                 240 


His Leu 
        


<210> 5307
<211> 43
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<400> 5307
Met Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Xaa Arg Lys Ala 
1               5                   10                  15      


Gln Leu Gln Leu Leu Gly Ala Val Cys Met Leu Leu Ala Ser Lys Leu 
            20                  25                  30          


Arg Glu Xaa Xaa Pro Leu Xaa Ile Glu Lys Leu 
        35                  40              


<210> 5308
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<400> 5308
Met Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Xaa Arg Lys Ala 
1               5                   10                  15      


Gln Leu Gln Leu Leu Gly Ala Val Cys Met Leu Leu Ala Ser Lys Leu 
            20                  25                  30          


Arg Glu Xaa Xaa Pro Leu Xaa Ile Glu Lys Leu Cys Ile Tyr Xaa Asp 
        35                  40                  45              


His Ala Val Ser Pro Arg Gln Leu Arg Asp Trp Glu Val Leu Val Leu 
    50                  55                  60                  


Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe Leu 
65                  70                  75                  80  


Ala Phe Ile Leu His Arg Leu Ser Leu Pro Arg Asp Arg Gln Ala Leu 
                85                  90                  95      


Val Lys Lys His Ala Gln Xaa Phe Leu Ala Leu Cys Ala Xaa Asp Tyr 
            100                 105                 110         


Xaa Phe Ala Met Tyr Pro 
        115             


<210> 5309
<211> 211
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<400> 5309
Met Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Xaa Arg Lys Ala 
1               5                   10                  15      


Gln Leu Gln Leu Leu Gly Ala Val Cys Met Leu Leu Ala Ser Lys Leu 
            20                  25                  30          


Arg Glu Xaa Xaa Pro Leu Xaa Ile Glu Lys Leu Cys Ile Tyr Xaa Asp 
        35                  40                  45              


His Ala Val Ser Pro Arg Gln Leu Arg Asp Trp Glu Val Leu Val Leu 
    50                  55                  60                  


Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe Leu 
65                  70                  75                  80  


Ala Phe Ile Leu His Arg Leu Ser Leu Pro Arg Asp Arg Gln Ala Leu 
                85                  90                  95      


Val Lys Lys His Ala Gln Xaa Phe Leu Ala Leu Cys Ala Xaa Asp Tyr 
            100                 105                 110         


Xaa Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Xaa Gly Ser Ile Gly 
        115                 120                 125             


Ala Ala Val Gln Gly Leu Gly Ala Cys Ser Met Ser Gly Asp Glu Leu 
    130                 135                 140                 


Xaa Glu Leu Leu Ala Gly Ile Xaa Gly Xaa Glu Val Asp Cys Leu Arg 
145                 150                 155                 160 


Ala Cys Gln Glu Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu Arg Glu 
                165                 170                 175     


Ala Ser Gln Xaa Ser Ser Ser Pro Ala Pro Lys Ala Pro Arg Gly Ser 
            180                 185                 190         


Ser Ser Gln Gly Pro Ser Gln Xaa Ser Xaa Pro Xaa Asp Val Xaa Ala 
        195                 200                 205             


Ile His Leu 
    210     


<210> 5310
<211> 195
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<400> 5310
Met Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Xaa Arg Lys Ala 
1               5                   10                  15      


Gln Leu Gln Leu Leu Gly Ala Val Cys Met Leu Leu Ala Ser Lys Leu 
            20                  25                  30          


Arg Glu Xaa Xaa Pro Leu Xaa Ile Glu Lys Leu Cys Ile Tyr Xaa Asp 
        35                  40                  45              


His Ala Val Ser Pro Arg Gln Leu Arg Asp Trp Glu Val Leu Val Leu 
    50                  55                  60                  


Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe Leu 
65                  70                  75                  80  


Ala Phe Ile Leu His Arg Leu Ser Leu Pro Arg Asp Arg Gln Ala Leu 
                85                  90                  95      


Val Lys Lys His Ala Gln Xaa Phe Leu Ala Leu Cys Ala Xaa Gly Leu 
            100                 105                 110         


Pro Ala Gly Leu Ser Gly Ala Asp Arg Ser Cys Xaa Gln Gly Glu Pro 
        115                 120                 125             


Gln Gly Ser Leu Ser Asp Gln Leu Gln Pro Ser Ala Gln Ser Pro Pro 
    130                 135                 140                 


Gly Leu Gln Gln Pro Arg Ala Gln Pro Asp Gln His Ser Tyr Arg Cys 
145                 150                 155                 160 


His Ser His Xaa Pro Val Ala Leu Glu Arg Pro Ser Gly Val Ala Xaa 
                165                 170                 175     


Lys Gln Arg Arg Gly Arg Cys His Pro Pro Pro Cys Leu Gln Glu Pro 
            180                 185                 190         


His His Ile 
        195 


<210> 5311
<211> 10
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<400> 5311
Met Tyr Pro Pro Ser Met Ile Ala Xaa Gly 
1               5                   10  


<210> 5312
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 5312
Met Tyr Pro Pro Ser Met Ile Ala Xaa Gly Ser Ile Gly Ala Ala Val 
1               5                   10                  15      


Gln Gly Leu Gly Ala Cys Ser Met Ser Gly Asp Glu Leu Xaa Glu Leu 
            20                  25                  30          


Leu Ala Gly Ile Xaa Gly Xaa Glu Val Asp Cys Leu Arg Ala Cys Gln 
        35                  40                  45              


Glu Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu Arg Glu Ala Ser Gln 
    50                  55                  60                  


Xaa Ser Ser Ser Pro Ala Pro Lys Ala Pro Arg Gly Ser Ser Ser Gln 
65                  70                  75                  80  


Gly Pro Ser Gln Xaa Ser Xaa Pro Xaa Asp Val Xaa Ala Ile His Leu 
                85                  90                  95      


<210> 5313
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 5313
Val Cys Glu Glu Gln Arg Cys Glu Glu Glu Val Phe Pro Leu Ala Met 
1               5                   10                  15      


Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Xaa Arg Lys Ala Gln 
            20                  25                  30          


Leu Gln Leu Leu Gly Ala Val Cys Met Leu Leu Ala Ser Lys Leu Arg 
        35                  40                  45              


Glu Xaa Xaa Pro Leu Xaa Ile Glu Lys Leu Cys Ile Tyr Xaa Asp His 
    50                  55                  60                  


Ala Val Ser Pro Arg Gln Leu Arg Asp Trp Glu Val Leu Val Leu Gly 
65                  70                  75                  80  


Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe Leu Ala 
                85                  90                  95      


Phe Ile Leu His Arg Leu Ser Leu Pro Arg Asp Arg Gln Ala Leu Val 
            100                 105                 110         


Lys Lys His Ala Gln Xaa Phe Leu Ala Leu Cys Ala Xaa Asp Tyr Xaa 
        115                 120                 125             


Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Xaa Gly Ser Ile Gly Ala 
    130                 135                 140                 


Ala Val Gln Gly Leu Gly Ala Cys Ser Met Ser Gly Asp Glu Leu Xaa 
145                 150                 155                 160 


Glu Leu Leu Ala Gly Ile Xaa Gly Xaa Glu Val Val Ser Ala Gly 
                165                 170                 175 


<210> 5314
<211> 283
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<400> 5314
Asp Asp Arg Val Tyr Pro Asn Ser Xaa Cys Lys Pro Arg Ile Ile Ala 
1               5                   10                  15      


Pro Ser Arg Gly Ser Pro Leu Pro Val Leu Ser Trp Ala Asn Arg Glu 
            20                  25                  30          


Glu Val Trp Lys Ile Met Leu Asn Lys Glu Lys Xaa Tyr Leu Arg Asp 
        35                  40                  45              


Gln His Phe Leu Glu Gln His Pro Leu Leu Gln Pro Lys Met Arg Ala 
    50                  55                  60                  


Ile Leu Leu Asp Trp Leu Met Glu Val Cys Glu Val Tyr Lys Leu His 
65                  70                  75                  80  


Arg Glu Xaa Phe Tyr Leu Ala Gln Asp Phe Phe Asp Arg Tyr Met Ala 
                85                  90                  95      


Xaa Gln Glu Asn Val Val Lys Xaa Leu Leu Gln Leu Ile Gly Ile Ser 
            100                 105                 110         


Ser Leu Phe Ile Ala Ala Lys Leu Glu Glu Ile Tyr Pro Pro Lys Leu 
        115                 120                 125             


His Gln Phe Ala Tyr Val Xaa Asp Gly Ala Cys Ser Gly Asp Glu Ile 
    130                 135                 140                 


Leu Xaa Met Glu Leu Met Ile Met Lys Leu Leu Asp Leu Cys Val Leu 
145                 150                 155                 160 


Asp Val Asp Cys Leu Glu Phe Pro Tyr Gly Ile Leu Ala Ala Ser Ala 
                165                 170                 175     


Leu Tyr His Phe Ser Ser Ser Glu Leu Met Gln Lys Val Ser Gly Tyr 
            180                 185                 190         


Gln Trp Cys Asp Ile Glu Asn Cys Val Lys Trp Met Val Pro Phe Ala 
        195                 200                 205             


Met Val Ile Arg Glu Xaa Gly Ser Ser Lys Leu Lys His Phe Arg Gly 
    210                 215                 220                 


Val Ala Asp Glu Asp Ala His Asn Ile Gln Xaa His Arg Asp Ser Leu 
225                 230                 235                 240 


Asp Leu Leu Asp Lys Ala Arg Ala Lys Lys Ala Met Leu Ser Glu Gln 
                245                 250                 255     


Asn Arg Ala Ser Pro Leu Pro Ser Gly Leu Leu Xaa Pro Pro Gln Ser 
            260                 265                 270         


Gly Lys Lys Gln Ser Ser Gly Pro Glu Met Ala 
        275                 280             


<210> 5315
<211> 395
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<400> 5315
Met Lys Glu Asp Gly Gly Ala Glu Phe Ser Ala Arg Ser Arg Lys Arg 
1               5                   10                  15      


Lys Ala Asn Val Xaa Val Phe Leu Gln Asp Pro Asp Glu Glu Met Ala 
            20                  25                  30          


Lys Ile Asp Arg Xaa Ala Arg Asp Gln Cys Gly Ser Gln Pro Trp Asp 
        35                  40                  45              


Asn Asn Ala Val Cys Ala Asp Pro Cys Ser Leu Ile Pro Xaa Pro Asp 
    50                  55                  60                  


Lys Glu Asp Asp Asp Arg Val Tyr Pro Asn Ser Xaa Cys Lys Pro Arg 
65                  70                  75                  80  


Ile Ile Ala Pro Ser Arg Gly Ser Pro Leu Pro Val Leu Ser Trp Ala 
                85                  90                  95      


Asn Arg Glu Glu Val Trp Lys Ile Met Leu Asn Lys Glu Lys Xaa Tyr 
            100                 105                 110         


Leu Arg Asp Gln His Phe Leu Glu Gln His Pro Leu Leu Gln Pro Lys 
        115                 120                 125             


Met Arg Ala Ile Leu Leu Asp Trp Leu Met Glu Val Cys Glu Val Tyr 
    130                 135                 140                 


Lys Leu His Arg Glu Xaa Phe Tyr Leu Ala Gln Asp Phe Phe Asp Arg 
145                 150                 155                 160 


Tyr Met Ala Xaa Gln Glu Asn Val Val Lys Xaa Leu Leu Gln Leu Ile 
                165                 170                 175     


Gly Ile Ser Ser Leu Phe Ile Ala Ala Lys Leu Glu Glu Ile Tyr Pro 
            180                 185                 190         


Pro Lys Leu His Gln Phe Ala Tyr Val Xaa Asp Gly Ala Cys Ser Gly 
        195                 200                 205             


Asp Glu Ile Leu Xaa Met Glu Leu Met Ile Met Lys Ala Leu Lys Trp 
    210                 215                 220                 


Arg Leu Ser Pro Leu Xaa Ile Val Ser Trp Leu Asn Val Tyr Met Gln 
225                 230                 235                 240 


Val Ala Tyr Leu Asn Asp Leu His Glu Val Leu Leu Pro Gln Tyr Pro 
                245                 250                 255     


Gln Gln Ile Phe Ile Gln Ile Ala Glu Leu Leu Asp Leu Cys Val Leu 
            260                 265                 270         


Asp Val Asp Cys Leu Glu Phe Pro Tyr Gly Ile Leu Ala Ala Ser Ala 
        275                 280                 285             


Leu Tyr His Phe Ser Ser Ser Glu Leu Met Gln Lys Val Ser Gly Tyr 
    290                 295                 300                 


Gln Trp Cys Asp Ile Glu Asn Cys Val Lys Trp Met Val Pro Phe Ala 
305                 310                 315                 320 


Met Val Ile Arg Glu Xaa Gly Ser Ser Lys Leu Lys His Phe Arg Gly 
                325                 330                 335     


Val Ala Asp Glu Asp Ala His Asn Ile Gln Xaa His Arg Asp Ser Leu 
            340                 345                 350         


Asp Leu Leu Asp Lys Ala Arg Ala Lys Lys Ala Met Leu Ser Glu Gln 
        355                 360                 365             


Asn Arg Ala Ser Pro Leu Pro Ser Gly Leu Leu Xaa Pro Pro Gln Ser 
    370                 375                 380                 


Gly Lys Lys Gln Ser Ser Gly Pro Glu Met Ala 
385                 390                 395 


<210> 5316
<211> 350
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<400> 5316
Met Lys Glu Asp Gly Gly Ala Glu Phe Ser Ala Arg Ser Arg Lys Arg 
1               5                   10                  15      


Lys Ala Asn Val Xaa Val Phe Leu Gln Asp Pro Asp Glu Glu Met Ala 
            20                  25                  30          


Lys Ile Asp Arg Xaa Ala Arg Asp Gln Cys Gly Ser Gln Pro Trp Asp 
        35                  40                  45              


Asn Asn Ala Val Cys Ala Asp Pro Cys Ser Leu Ile Pro Xaa Pro Asp 
    50                  55                  60                  


Lys Glu Asp Asp Asp Arg Val Tyr Pro Asn Ser Xaa Cys Lys Pro Arg 
65                  70                  75                  80  


Ile Ile Ala Pro Ser Arg Gly Ser Pro Leu Pro Val Leu Ser Trp Ala 
                85                  90                  95      


Asn Arg Glu Glu Val Trp Lys Ile Met Leu Asn Lys Glu Lys Xaa Tyr 
            100                 105                 110         


Leu Arg Asp Gln His Phe Leu Glu Gln His Pro Leu Leu Gln Pro Lys 
        115                 120                 125             


Met Arg Ala Ile Leu Leu Asp Trp Leu Met Glu Val Cys Glu Val Tyr 
    130                 135                 140                 


Lys Leu His Arg Glu Xaa Phe Tyr Leu Ala Gln Asp Phe Phe Asp Arg 
145                 150                 155                 160 


Tyr Met Ala Xaa Gln Glu Asn Val Val Lys Xaa Leu Leu Gln Leu Ile 
                165                 170                 175     


Gly Ile Ser Ser Leu Phe Ile Ala Ala Lys Leu Glu Glu Ile Tyr Pro 
            180                 185                 190         


Pro Lys Leu His Gln Phe Ala Tyr Val Xaa Asp Gly Ala Cys Ser Gly 
        195                 200                 205             


Asp Glu Ile Leu Xaa Met Glu Leu Met Ile Met Lys Leu Leu Asp Leu 
    210                 215                 220                 


Cys Val Leu Asp Val Asp Cys Leu Glu Phe Pro Tyr Gly Ile Leu Ala 
225                 230                 235                 240 


Ala Ser Ala Leu Tyr His Phe Ser Ser Ser Glu Leu Met Gln Lys Val 
                245                 250                 255     


Ser Gly Tyr Gln Trp Cys Asp Ile Glu Asn Cys Val Lys Trp Met Val 
            260                 265                 270         


Pro Phe Ala Met Val Ile Arg Glu Xaa Gly Ser Ser Lys Leu Lys His 
        275                 280                 285             


Phe Arg Gly Val Ala Asp Glu Asp Ala His Asn Ile Gln Xaa His Arg 
    290                 295                 300                 


Asp Ser Leu Asp Leu Leu Asp Lys Ala Arg Ala Lys Lys Ala Met Leu 
305                 310                 315                 320 


Ser Glu Gln Asn Arg Ala Ser Pro Leu Pro Ser Gly Leu Leu Xaa Pro 
                325                 330                 335     


Pro Gln Ser Gly Lys Lys Gln Ser Ser Gly Pro Glu Met Ala 
            340                 345                 350 


<210> 5317
<211> 216
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<400> 5317
Met Pro Arg Glu Arg Arg Glu Arg Asp Ala Lys Glu Arg Asp Xaa Met 
1               5                   10                  15      


Lys Glu Asp Gly Gly Ala Glu Phe Ser Ala Arg Ser Arg Lys Arg Lys 
            20                  25                  30          


Ala Asn Val Xaa Val Asp Pro Asp Glu Glu Met Ala Lys Ile Asp Arg 
        35                  40                  45              


Xaa Ala Arg Asp Gln Cys Gly Ser Gln Pro Trp Asp Asn Asn Ala Val 
    50                  55                  60                  


Cys Ala Asp Pro Cys Ser Leu Ile Pro Xaa Pro Asp Lys Glu Asp Asp 
65                  70                  75                  80  


Asp Arg Val Tyr Pro Asn Ser Xaa Cys Lys Pro Arg Ile Ile Ala Pro 
                85                  90                  95      


Ser Arg Gly Ser Pro Leu Pro Val Leu Ser Trp Ala Asn Arg Glu Glu 
            100                 105                 110         


Val Trp Lys Ile Met Leu Asn Lys Glu Lys Xaa Tyr Leu Arg Asp Gln 
        115                 120                 125             


His Phe Leu Glu Gln His Pro Leu Leu Gln Pro Lys Met Arg Ala Ile 
    130                 135                 140                 


Leu Leu Asp Trp Leu Met Glu Val Cys Glu Val Tyr Lys Leu His Arg 
145                 150                 155                 160 


Glu Xaa Phe Tyr Leu Ala Gln Asp Phe Phe Asp Arg Tyr Met Ala Xaa 
                165                 170                 175     


Gln Glu Asn Val Val Lys Xaa Leu Leu Gln Leu Ile Gly Ile Ser Ser 
            180                 185                 190         


Leu Phe Ile Ala Ala Lys Leu Glu Glu Ile Tyr Pro Pro Lys Leu His 
        195                 200                 205             


Gln Phe Ala Tyr Val Xaa Asp Gly 
    210                 215     


<210> 5318
<211> 410
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<400> 5318
Met Pro Arg Glu Arg Arg Glu Arg Asp Ala Lys Glu Arg Asp Xaa Met 
1               5                   10                  15      


Lys Glu Asp Gly Gly Ala Glu Phe Ser Ala Arg Ser Arg Lys Arg Lys 
            20                  25                  30          


Ala Asn Val Xaa Val Phe Leu Gln Asp Pro Asp Glu Glu Met Ala Lys 
        35                  40                  45              


Ile Asp Arg Xaa Ala Arg Asp Gln Cys Gly Ser Gln Pro Trp Asp Asn 
    50                  55                  60                  


Asn Ala Val Cys Ala Asp Pro Cys Ser Leu Ile Pro Xaa Pro Asp Lys 
65                  70                  75                  80  


Glu Asp Asp Asp Arg Val Tyr Pro Asn Ser Xaa Cys Lys Pro Arg Ile 
                85                  90                  95      


Ile Ala Pro Ser Arg Gly Ser Pro Leu Pro Val Leu Ser Trp Ala Asn 
            100                 105                 110         


Arg Glu Glu Val Trp Lys Ile Met Leu Asn Lys Glu Lys Xaa Tyr Leu 
        115                 120                 125             


Arg Asp Gln His Phe Leu Glu Gln His Pro Leu Leu Gln Pro Lys Met 
    130                 135                 140                 


Arg Ala Ile Leu Leu Asp Trp Leu Met Glu Val Cys Glu Val Tyr Lys 
145                 150                 155                 160 


Leu His Arg Glu Xaa Phe Tyr Leu Ala Gln Asp Phe Phe Asp Arg Tyr 
                165                 170                 175     


Met Ala Xaa Gln Glu Asn Val Val Lys Xaa Leu Leu Gln Leu Ile Gly 
            180                 185                 190         


Ile Ser Ser Leu Phe Ile Ala Ala Lys Leu Glu Glu Ile Tyr Pro Pro 
        195                 200                 205             


Lys Leu His Gln Phe Ala Tyr Val Xaa Asp Gly Ala Cys Ser Gly Asp 
    210                 215                 220                 


Glu Ile Leu Xaa Met Glu Leu Met Ile Met Lys Ala Leu Lys Trp Arg 
225                 230                 235                 240 


Leu Ser Pro Leu Xaa Ile Val Ser Trp Leu Asn Val Tyr Met Gln Val 
                245                 250                 255     


Ala Tyr Leu Asn Asp Leu His Glu Val Leu Leu Pro Gln Tyr Pro Gln 
            260                 265                 270         


Gln Ile Phe Ile Gln Ile Ala Glu Leu Leu Asp Leu Cys Val Leu Asp 
        275                 280                 285             


Val Asp Cys Leu Glu Phe Pro Tyr Gly Ile Leu Ala Ala Ser Ala Leu 
    290                 295                 300                 


Tyr His Phe Ser Ser Ser Glu Leu Met Gln Lys Val Ser Gly Tyr Gln 
305                 310                 315                 320 


Trp Cys Asp Ile Glu Asn Cys Val Lys Trp Met Val Pro Phe Ala Met 
                325                 330                 335     


Val Ile Arg Glu Xaa Gly Ser Ser Lys Leu Lys His Phe Arg Gly Val 
            340                 345                 350         


Ala Asp Glu Asp Ala His Asn Ile Gln Xaa His Arg Asp Ser Leu Asp 
        355                 360                 365             


Leu Leu Asp Lys Ala Arg Ala Lys Lys Ala Met Leu Ser Glu Gln Asn 
    370                 375                 380                 


Arg Ala Ser Pro Leu Pro Ser Gly Leu Leu Xaa Pro Pro Gln Ser Gly 
385                 390                 395                 400 


Lys Lys Gln Ser Ser Gly Pro Glu Met Ala 
                405                 410 


<210> 5319
<211> 52
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<400> 5319
Met Glu Phe Asn Pro Ser Asp His Pro Arg Ala Ser Xaa Ile Phe Leu 
1               5                   10                  15      


Ser Lys Ser Gln Xaa Asp Val Arg Glu Lys Arg Lys Ser Leu Phe Ile 
            20                  25                  30          


Asn His His Pro Pro Gly Gln Ile Ala Arg Lys Tyr Ser Ser Cys Ser 
        35                  40                  45              


Xaa Ile Phe Leu 
    50          


<210> 5320
<211> 287
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<400> 5320
Met Glu Phe Asn Pro Ser Asp His Pro Arg Ala Ser Xaa Ile Phe Leu 
1               5                   10                  15      


Ser Lys Ser Gln Xaa Asp Val Arg Glu Lys Arg Lys Ser Leu Phe Ile 
            20                  25                  30          


Asn His His Pro Pro Gly Gln Ile Ala Arg Lys Tyr Ser Ser Cys Ser 
        35                  40                  45              


Xaa Ile Phe Leu Asp Asp Ser Xaa Val Ser Gln Pro Asn Leu Lys Tyr 
    50                  55                  60                  


Xaa Ile Lys Cys Val Ala Leu Ala Ile Tyr Tyr His Ile Lys Asn Arg 
65                  70                  75                  80  


Asp Pro Asp Gly Arg Met Leu Leu Asp Ile Phe Asp Glu Asn Leu His 
                85                  90                  95      


Pro Leu Ser Lys Ser Glu Val Pro Pro Asp Tyr Asp Lys His Asn Pro 
            100                 105                 110         


Glu Gln Lys Gln Ile Tyr Arg Phe Val Arg Xaa Leu Phe Ser Ala Ala 
        115                 120                 125             


Gln Leu Xaa Ala Glu Cys Ala Ile Val Xaa Leu Val Tyr Leu Glu Arg 
    130                 135                 140                 


Leu Leu Xaa Tyr Ala Glu Ile Asp Ile Cys Pro Ala Asn Trp Lys Arg 
145                 150                 155                 160 


Ile Val Leu Gly Ala Ile Leu Leu Ala Ser Lys Val Trp Asp Asp Gln 
                165                 170                 175     


Ala Val Trp Asn Val Asp Tyr Cys Gln Ile Leu Lys Asp Ile Xaa Val 
            180                 185                 190         


Glu Asp Met Asn Glu Leu Glu Arg Gln Phe Leu Glu Leu Leu Gln Phe 
        195                 200                 205             


Asn Ile Asn Val Pro Ser Ser Val Tyr Ala Lys Tyr Tyr Phe Asp Leu 
    210                 215                 220                 


Arg Ser Leu Ala Glu Ala Asn Asn Leu Ser Phe Pro Leu Glu Pro Leu 
225                 230                 235                 240 


Ser Arg Glu Arg Ala His Lys Leu Glu Ala Ile Ser Arg Leu Cys Glu 
                245                 250                 255     


Asp Lys Tyr Lys Asp Leu Arg Arg Ser Ala Arg Lys Arg Ser Ala Ser 
            260                 265                 270         


Ala Asp Asn Leu Xaa Leu Pro Arg Trp Ser Pro Ala Ile Ile Ser 
        275                 280                 285         


<210> 5321
<211> 101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<400> 5321
Met Glu Phe Asn Pro Ser Asp His Pro Arg Ala Ser Xaa Ile Phe Leu 
1               5                   10                  15      


Ser Lys Ser Gln Xaa Asp Val Arg Glu Lys Arg Lys Ser Leu Phe Ile 
            20                  25                  30          


Asn His His Pro Pro Gly Gln Ile Ala Arg Lys Tyr Ser Ser Cys Ser 
        35                  40                  45              


Xaa Ile Phe Leu Asp Asp Ser Xaa Val Ser Gln Pro Asn Leu Lys Tyr 
    50                  55                  60                  


Xaa Ile Lys Cys Val Ala Leu Ala Ile Tyr Tyr His Ile Lys Asn Arg 
65                  70                  75                  80  


Asp Pro Asp Gly Arg Met Leu Leu Asp Ile Phe Asp Glu Asn Leu His 
                85                  90                  95      


Pro Leu Ser Val Ile 
            100     


<210> 5322
<211> 341
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<400> 5322
Met Gly Asn Xaa Xaa Ser Cys Cys Val Ser Ser Ser Pro Lys Leu Arg 
1               5                   10                  15      


Arg Asn Ala His Ser Arg Leu Glu Ser Tyr Arg Pro Asp Xaa Asp Leu 
            20                  25                  30          


Ser Arg Glu Asp Xaa Gly Cys Asn Leu Gln His Ile Ser Asp Arg Glu 
        35                  40                  45              


Asn Ile Asp Asp Leu Asn Met Glu Phe Asn Pro Ser Asp His Pro Arg 
    50                  55                  60                  


Ala Ser Xaa Ile Phe Leu Ser Lys Ser Gln Xaa Asp Val Arg Glu Lys 
65                  70                  75                  80  


Arg Lys Ser Leu Phe Ile Asn His His Pro Pro Gly Gln Ile Ala Arg 
                85                  90                  95      


Lys Tyr Ser Ser Cys Ser Xaa Ile Phe Leu Asp Asp Ser Xaa Val Ser 
            100                 105                 110         


Gln Pro Asn Leu Lys Tyr Xaa Ile Lys Cys Val Ala Leu Ala Ile Tyr 
        115                 120                 125             


Tyr His Ile Lys Asn Arg Asp Pro Asp Gly Arg Met Leu Leu Asp Ile 
    130                 135                 140                 


Phe Asp Glu Asn Leu His Pro Leu Ser Lys Ser Glu Val Pro Pro Asp 
145                 150                 155                 160 


Tyr Asp Lys His Asn Pro Glu Gln Lys Gln Ile Tyr Arg Phe Val Arg 
                165                 170                 175     


Xaa Leu Phe Ser Ala Ala Gln Leu Xaa Ala Glu Cys Ala Ile Val Xaa 
            180                 185                 190         


Leu Val Tyr Leu Glu Arg Leu Leu Xaa Tyr Ala Glu Ile Asp Ile Cys 
        195                 200                 205             


Pro Ala Asn Trp Lys Arg Ile Val Leu Gly Ala Ile Leu Leu Ala Ser 
    210                 215                 220                 


Lys Val Trp Asp Asp Gln Ala Val Trp Asn Val Asp Tyr Cys Gln Ile 
225                 230                 235                 240 


Leu Lys Asp Ile Xaa Val Glu Asp Met Asn Glu Leu Glu Arg Gln Phe 
                245                 250                 255     


Leu Glu Leu Leu Gln Phe Asn Ile Asn Val Pro Ser Ser Val Tyr Ala 
            260                 265                 270         


Lys Tyr Tyr Phe Asp Leu Arg Ser Leu Ala Glu Ala Asn Asn Leu Ser 
        275                 280                 285             


Phe Pro Leu Glu Pro Leu Ser Arg Glu Arg Ala His Lys Leu Glu Ala 
    290                 295                 300                 


Ile Ser Arg Leu Cys Glu Asp Lys Tyr Lys Asp Leu Arg Arg Ser Ala 
305                 310                 315                 320 


Arg Lys Arg Ser Ala Ser Ala Asp Asn Leu Xaa Leu Pro Arg Trp Ser 
                325                 330                 335     


Pro Ala Ile Ile Ser 
            340     


<210> 5323
<211> 316
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<400> 5323
Met Gly Asn Xaa Xaa Ser Cys Cys Val Ser Ser Ser Pro Lys Leu Arg 
1               5                   10                  15      


Arg Asn Ala His Ser Arg Leu Glu Ser Tyr Arg Pro Asp Xaa Asp Leu 
            20                  25                  30          


Ser Arg Glu Asp Xaa Gly Cys Asn Leu Gln His Ile Ser Asp Arg Glu 
        35                  40                  45              


Asn Ile Asp Val Arg Glu Lys Arg Lys Ser Leu Phe Ile Asn His His 
    50                  55                  60                  


Pro Pro Gly Gln Ile Ala Arg Lys Tyr Ser Ser Cys Ser Xaa Ile Phe 
65                  70                  75                  80  


Leu Asp Asp Ser Xaa Val Ser Gln Pro Asn Leu Lys Tyr Xaa Ile Lys 
                85                  90                  95      


Cys Val Ala Leu Ala Ile Tyr Tyr His Ile Lys Asn Arg Asp Pro Asp 
            100                 105                 110         


Gly Arg Met Leu Leu Asp Ile Phe Asp Glu Asn Leu His Pro Leu Ser 
        115                 120                 125             


Lys Ser Glu Val Pro Pro Asp Tyr Asp Lys His Asn Pro Glu Gln Lys 
    130                 135                 140                 


Gln Ile Tyr Arg Phe Val Arg Xaa Leu Phe Ser Ala Ala Gln Leu Xaa 
145                 150                 155                 160 


Ala Glu Cys Ala Ile Val Xaa Leu Val Tyr Leu Glu Arg Leu Leu Xaa 
                165                 170                 175     


Tyr Ala Glu Ile Asp Ile Cys Pro Ala Asn Trp Lys Arg Ile Val Leu 
            180                 185                 190         


Gly Ala Ile Leu Leu Ala Ser Lys Val Trp Asp Asp Gln Ala Val Trp 
        195                 200                 205             


Asn Val Asp Tyr Cys Gln Ile Leu Lys Asp Ile Xaa Val Glu Asp Met 
    210                 215                 220                 


Asn Glu Leu Glu Arg Gln Phe Leu Glu Leu Leu Gln Phe Asn Ile Asn 
225                 230                 235                 240 


Val Pro Ser Ser Val Tyr Ala Lys Tyr Tyr Phe Asp Leu Arg Ser Leu 
                245                 250                 255     


Ala Glu Ala Asn Asn Leu Ser Phe Pro Leu Glu Pro Leu Ser Arg Glu 
            260                 265                 270         


Arg Ala His Lys Leu Glu Ala Ile Ser Arg Leu Cys Glu Asp Lys Tyr 
        275                 280                 285             


Lys Asp Leu Arg Arg Ser Ala Arg Lys Arg Ser Ala Ser Ala Asp Asn 
    290                 295                 300                 


Leu Xaa Leu Pro Arg Trp Ser Pro Ala Ile Ile Ser 
305                 310                 315     


<210> 5324
<211> 355
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<400> 5324
Met Glu Xaa Pro Asn Xaa Xaa Glu Asp Tyr Asp Xaa Xaa Xaa Glu Phe 
1               5                   10                  15      


Asp Tyr Gly Asp Ala Xaa Pro Cys Gln Lys Val Asn Glu Arg Ala Phe 
            20                  25                  30          


Gly Ala Gln Leu Leu Pro Pro Leu Tyr Ser Leu Val Phe Val Ile Gly 
        35                  40                  45              


Leu Val Gly Asn Ile Leu Val Val Leu Val Leu Val Gln Tyr Lys Arg 
    50                  55                  60                  


Leu Lys Asn Met Xaa Ser Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


Leu Leu Phe Leu Phe Xaa Leu Pro Phe Trp Ile Asp Tyr Lys Leu Lys 
                85                  90                  95      


Asp Asp Trp Val Phe Gly Asp Ala Met Cys Lys Ile Leu Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Xaa Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Xaa 
        115                 120                 125             


Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala 
    130                 135                 140                 


Arg Xaa Val Xaa Phe Gly Val Ile Xaa Ser Ile Ile Ile Trp Ala Leu 
145                 150                 155                 160 


Ala Ile Leu Ala Ser Met Pro Gly Leu Tyr Phe Ser Lys Xaa Gln Trp 
                165                 170                 175     


Glu Phe Xaa His His Xaa Cys Ser Leu His Phe Pro His Glu Ser Leu 
            180                 185                 190         


Arg Glu Trp Lys Leu Phe Gln Ala Leu Lys Leu Asn Leu Phe Gly Leu 
        195                 200                 205             


Val Leu Pro Leu Leu Val Met Ile Ile Cys Tyr Xaa Gly Ile Ile Lys 
    210                 215                 220                 


Ile Leu Leu Arg Arg Pro Asn Glu Lys Lys Ser Lys Ala Val Arg Leu 
225                 230                 235                 240 


Ile Phe Val Ile Met Ile Ile Phe Phe Leu Phe Trp Xaa Pro Tyr Asn 
                245                 250                 255     


Leu Xaa Ile Leu Ile Ser Val Phe Gln Asp Phe Leu Phe Xaa His Glu 
            260                 265                 270         


Cys Glu Gln Ser Arg His Leu Asp Leu Ala Val Gln Val Xaa Glu Val 
        275                 280                 285             


Ile Ala Tyr Xaa His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val 
    290                 295                 300                 


Gly Glu Arg Phe Arg Lys Tyr Leu Arg Gln Leu Phe His Arg Arg Val 
305                 310                 315                 320 


Ala Val His Leu Val Lys Trp Leu Pro Phe Leu Ser Val Asp Arg Leu 
                325                 330                 335     


Glu Arg Val Ser Ser Xaa Ser Pro Ser Xaa Gly Glu His Glu Leu Ser 
            340                 345                 350         


Ala Gly Phe 
        355 


<210> 5325
<211> 362
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<400> 5325
Met Gly Xaa Glu Ala Xaa Glu Gln Val Ser Trp Gly His Tyr Ser Gly 
1               5                   10                  15      


Asp Glu Glu Asp Ala Tyr Ser Ala Glu Pro Leu Pro Glu Leu Cys Tyr 
            20                  25                  30          


Lys Ala Asp Val Gln Ala Phe Ser Arg Ala Phe Gln Pro Ser Val Ser 
        35                  40                  45              


Leu Xaa Val Ala Ala Leu Gly Leu Ala Gly Asn Gly Leu Val Leu Ala 
    50                  55                  60                  


Xaa His Leu Ala Ala Arg Arg Ala Ala Arg Ser Pro Xaa Ser Ala His 
65                  70                  75                  80  


Leu Leu Gln Leu Ala Leu Ala Asp Leu Leu Leu Ala Leu Xaa Leu Pro 
                85                  90                  95      


Phe Ala Ala Ala Gly Ala Leu Gln Gly Trp Ser Leu Gly Ser Ala Xaa 
            100                 105                 110         


Cys Arg Xaa Ile Ser Gly Leu Tyr Ser Ala Ser Phe His Ala Gly Phe 
        115                 120                 125             


Leu Phe Leu Ala Cys Ile Ser Ala Asp Arg Tyr Val Ala Ile Ala Arg 
    130                 135                 140                 


Ala Leu Pro Ala Gly Pro Arg Pro Ser Xaa Pro Gly Arg Ala His Leu 
145                 150                 155                 160 


Val Ser Val Ile Val Trp Leu Leu Ser Leu Leu Leu Ala Leu Pro Ala 
                165                 170                 175     


Leu Leu Phe Ser Gln Asp Gly Gln Arg Glu Gly Gln Arg Arg Cys Arg 
            180                 185                 190         


Leu Ile Phe Pro Glu Gly Leu Xaa Gln Xaa Val Lys Gly Ala Ser Ala 
        195                 200                 205             


Val Ala Gln Val Ala Leu Gly Phe Ala Leu Pro Leu Gly Val Met Val 
    210                 215                 220                 


Ala Cys Tyr Ala Leu Leu Gly Arg Xaa Leu Leu Ala Ala Arg Gly Pro 
225                 230                 235                 240 


Glu Arg Arg Arg Ala Leu Arg Val Val Val Ala Leu Val Ala Ala Phe 
                245                 250                 255     


Val Val Leu Gln Leu Pro Tyr Ser Leu Ala Leu Leu Leu Asp Xaa Ala 
            260                 265                 270         


Asp Leu Leu Ala Ala Arg Glu Arg Ser Cys Pro Ala Ser Lys Arg Lys 
        275                 280                 285             


Asp Val Ala Leu Leu Val Xaa Ser Gly Leu Ala Leu Ala Arg Cys Gly 
    290                 295                 300                 


Leu Asn Pro Val Leu Tyr Ala Phe Leu Gly Leu Arg Phe Arg Gln Asp 
305                 310                 315                 320 


Leu Arg Arg Leu Leu Arg Gly Gly Ser Cys Pro Ser Gly Pro Gln Pro 
                325                 330                 335     


Arg Arg Gly Cys Pro Arg Arg Pro Arg Leu Ser Ser Cys Ser Ala Pro 
            340                 345                 350         


Xaa Glu Xaa His Ser Leu Ser Trp Asp Asn 
        355                 360         


<210> 5326
<211> 83
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<400> 5326
Met Val Ala Cys Tyr Ala Leu Leu Gly Arg Xaa Leu Leu Ala Ala Arg 
1               5                   10                  15      


Gly Pro Glu Arg Arg Arg Ala Leu Arg Val Val Val Ala Leu Val Ala 
            20                  25                  30          


Ala Phe Val Val Leu Gln Leu Pro Tyr Ser Leu Ala Leu Leu Leu Asp 
        35                  40                  45              


Xaa Ala Asp Leu Leu Ala Ala Arg Glu Arg Ser Cys Pro Ala Ser Lys 
    50                  55                  60                  


Arg Lys Asp Val Ala Leu Leu Val Xaa Ser Gly Leu Ala Leu Ala Arg 
65                  70                  75                  80  


Cys Gly Leu 
            


<210> 5327
<211> 140
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<400> 5327
Met Val Ala Cys Tyr Ala Leu Leu Gly Arg Xaa Leu Leu Ala Ala Arg 
1               5                   10                  15      


Gly Pro Glu Arg Arg Arg Ala Leu Arg Val Val Val Ala Leu Val Ala 
            20                  25                  30          


Ala Phe Val Val Leu Gln Leu Pro Tyr Ser Leu Ala Leu Leu Leu Asp 
        35                  40                  45              


Xaa Ala Asp Leu Leu Ala Ala Arg Glu Arg Ser Cys Pro Ala Ser Lys 
    50                  55                  60                  


Arg Lys Asp Val Ala Leu Leu Val Xaa Ser Gly Leu Ala Leu Ala Arg 
65                  70                  75                  80  


Cys Gly Leu Asn Pro Val Leu Tyr Ala Phe Leu Gly Leu Arg Phe Arg 
                85                  90                  95      


Gln Asp Leu Arg Arg Leu Leu Arg Gly Gly Ser Cys Pro Ser Gly Pro 
            100                 105                 110         


Gln Pro Arg Arg Gly Cys Pro Arg Arg Pro Arg Leu Ser Ser Cys Ser 
        115                 120                 125             


Ala Pro Xaa Glu Xaa His Ser Leu Ser Trp Asp Asn 
    130                 135                 140 


<210> 5328
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 5328
Met Leu Ser Xaa Ser Arg Ser Arg Phe Ile Arg Asn Xaa Asn Glu Ser 
1               5                   10                  15      


Gly Glu Glu Val Xaa Xaa Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Cys 
            20                  25                  30          


His Lys Phe Asp Val Lys Gln Ile Gly Ala Gln Leu Leu Pro Pro Leu 
        35                  40                  45              


Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Val 
    50                  55                  60                  


Leu Ile Leu Ile Asn Cys Lys Lys Leu Lys Cys Leu Xaa Asp Ile Tyr 
65                  70                  75                  80  


Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Leu Ile Xaa Leu Pro 
                85                  90                  95      


Leu Trp Ala His Ser Ala Ala Asn Glu Trp Val Phe Gly Asn Ala Met 
            100                 105                 110         


Cys Lys Leu Phe Xaa Gly Leu Tyr His 
        115                 120     


<210> 5329
<211> 360
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<400> 5329
Met Leu Ser Xaa Ser Arg Ser Arg Phe Ile Arg Asn Xaa Asn Glu Ser 
1               5                   10                  15      


Gly Glu Glu Val Xaa Xaa Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Cys 
            20                  25                  30          


His Lys Phe Asp Val Lys Gln Ile Gly Ala Gln Leu Leu Pro Pro Leu 
        35                  40                  45              


Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Val 
    50                  55                  60                  


Leu Ile Leu Ile Asn Cys Lys Lys Leu Lys Cys Leu Xaa Asp Ile Tyr 
65                  70                  75                  80  


Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Leu Ile Xaa Leu Pro 
                85                  90                  95      


Leu Trp Ala His Ser Ala Ala Asn Glu Trp Val Phe Gly Asn Ala Met 
            100                 105                 110         


Cys Lys Leu Phe Xaa Gly Leu Tyr His Ile Gly Tyr Phe Gly Gly Ile 
        115                 120                 125             


Phe Phe Ile Ile Leu Leu Xaa Ile Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Val Phe Ala Leu Lys Ala Arg Xaa Val Xaa Phe Gly Val Val Xaa 
145                 150                 155                 160 


Ser Val Ile Xaa Trp Leu Val Ala Val Phe Ala Ser Val Pro Gly Ile 
                165                 170                 175     


Ile Phe Xaa Lys Cys Gln Lys Glu Asp Ser Val Tyr Val Cys Gly Pro 
            180                 185                 190         


Tyr Phe Pro Arg Gly Trp Asn Asn Phe His Xaa Ile Met Arg Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Leu Pro Leu Leu Ile Met Val Ile Cys Tyr Ser Gly 
    210                 215                 220                 


Ile Leu Lys Xaa Leu Leu Arg Cys Arg Asn Glu Lys Lys Arg His Arg 
225                 230                 235                 240 


Ala Val Arg Val Ile Phe Xaa Ile Met Ile Val Tyr Phe Leu Phe Trp 
                245                 250                 255     


Xaa Pro Tyr Asn Ile Val Ile Leu Leu Asn Xaa Phe Gln Glu Phe Phe 
            260                 265                 270         


Gly Leu Ser Asn Cys Glu Ser Xaa Ser Gln Leu Asp Gln Ala Xaa Gln 
        275                 280                 285             


Val Xaa Glu Xaa Leu Gly Met Xaa His Cys Cys Ile Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Val Gly Glu Lys Phe Arg Arg Tyr Leu Ser Val Phe Phe 
305                 310                 315                 320 


Arg Lys His Ile Xaa Lys Arg Phe Cys Lys Gln Cys Pro Val Phe Tyr 
                325                 330                 335     


Arg Glu Xaa Val Asp Gly Val Xaa Ser Xaa Asn Xaa Pro Ser Xaa Gly 
            340                 345                 350         


Glu Gln Glu Val Ser Ala Gly Leu 
        355                 360 


<210> 5330
<211> 374
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(347)
<223> Selenocysteine

<400> 5330
Met Leu Ser Xaa Ser Arg Ser Arg Phe Ile Arg Asn Xaa Asn Glu Ser 
1               5                   10                  15      


Gly Glu Glu Val Xaa Xaa Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Cys 
            20                  25                  30          


His Lys Phe Asp Val Lys Gln Ile Gly Ala Gln Leu Leu Pro Pro Leu 
        35                  40                  45              


Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Val 
    50                  55                  60                  


Leu Ile Leu Ile Asn Cys Lys Lys Leu Lys Cys Leu Xaa Asp Ile Tyr 
65                  70                  75                  80  


Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Leu Ile Xaa Leu Pro 
                85                  90                  95      


Leu Trp Ala His Ser Ala Ala Asn Glu Trp Val Phe Gly Asn Ala Met 
            100                 105                 110         


Cys Lys Leu Phe Xaa Gly Leu Tyr His Ile Gly Tyr Phe Gly Gly Ile 
        115                 120                 125             


Phe Phe Ile Ile Leu Leu Xaa Ile Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Val Phe Ala Leu Lys Ala Arg Xaa Val Xaa Phe Gly Val Val Xaa 
145                 150                 155                 160 


Ser Val Ile Xaa Trp Leu Val Ala Val Phe Ala Ser Val Pro Gly Ile 
                165                 170                 175     


Ile Phe Xaa Lys Cys Gln Lys Glu Asp Ser Val Tyr Val Cys Gly Pro 
            180                 185                 190         


Tyr Phe Pro Arg Gly Trp Asn Asn Phe His Xaa Ile Met Arg Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Leu Pro Leu Leu Ile Met Val Ile Cys Tyr Ser Gly 
    210                 215                 220                 


Ile Leu Lys Xaa Leu Leu Arg Cys Arg Asn Glu Lys Lys Arg His Arg 
225                 230                 235                 240 


Ala Val Arg Val Ile Phe Xaa Ile Met Ile Val Tyr Phe Leu Phe Trp 
                245                 250                 255     


Xaa Pro Tyr Asn Ile Val Ile Leu Leu Asn Xaa Phe Gln Glu Phe Phe 
            260                 265                 270         


Gly Leu Ser Asn Cys Glu Ser Xaa Ser Gln Leu Asp Gln Ala Xaa Gln 
        275                 280                 285             


Val Xaa Glu Xaa Leu Gly Met Xaa His Cys Cys Ile Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Val Gly Glu Lys Phe Arg Ser Leu Phe His Ile Ala Leu 
305                 310                 315                 320 


Gly Cys Arg Ile Ala Pro Leu Gln Lys Pro Val Cys Gly Gly Pro Gly 
                325                 330                 335     


Val Arg Pro Gly Lys Asn Val Lys Val Xaa Xaa Gln Gly Leu Leu Asp 
            340                 345                 350         


Gly Arg Gly Lys Gly Lys Ser Ile Gly Arg Ala Pro Glu Ala Ser Leu 
        355                 360                 365             


Gln Asp Lys Glu Gly Ala 
    370                 


<210> 5331
<211> 376
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<400> 5331
Met Pro Phe Gly Ile Arg Met Leu Leu Arg Ala His Lys Pro Gly Ser 
1               5                   10                  15      


Ser Arg Arg Ser Glu Met Xaa Xaa Ser Leu Asp Xaa Val Glu Xaa Phe 
            20                  25                  30          


Gly Xaa Xaa Ser Tyr Tyr Asp Asp Val Gly Leu Leu Cys Glu Lys Ala 
        35                  40                  45              


Asp Xaa Arg Ala Leu Met Ala Gln Phe Val Pro Pro Leu Tyr Ser Leu 
    50                  55                  60                  


Val Phe Xaa Val Gly Leu Leu Gly Asn Val Val Val Val Met Ile Leu 
65                  70                  75                  80  


Ile Lys Tyr Arg Arg Leu Arg Ile Met Xaa Asn Ile Tyr Leu Leu Asn 
                85                  90                  95      


Leu Ala Ile Ser Asp Leu Leu Phe Leu Val Xaa Leu Pro Phe Trp Ile 
            100                 105                 110         


His Tyr Val Arg Gly His Asn Trp Val Phe Gly His Gly Met Cys Lys 
        115                 120                 125             


Leu Leu Ser Gly Phe Tyr His Xaa Gly Leu Tyr Ser Glu Ile Phe Phe 
    130                 135                 140                 


Ile Ile Leu Leu Xaa Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val 
145                 150                 155                 160 


Phe Ala Leu Arg Ala Arg Xaa Val Xaa Phe Gly Val Ile Xaa Ser Ile 
                165                 170                 175     


Val Xaa Trp Gly Leu Ala Val Leu Ala Ala Leu Pro Glu Phe Ile Phe 
            180                 185                 190         


Tyr Glu Xaa Glu Glu Leu Phe Glu Glu Xaa Leu Cys Ser Ala Leu Tyr 
        195                 200                 205             


Pro Glu Asp Xaa Val Tyr Ser Trp Arg His Phe His Xaa Leu Arg Met 
    210                 215                 220                 


Xaa Ile Phe Cys Leu Val Leu Pro Leu Leu Val Met Ala Ile Cys Tyr 
225                 230                 235                 240 


Xaa Gly Ile Ile Lys Xaa Leu Leu Arg Cys Pro Ser Lys Lys Lys Tyr 
                245                 250                 255     


Lys Ala Ile Arg Leu Ile Phe Val Ile Met Ala Val Phe Phe Ile Phe 
            260                 265                 270         


Trp Xaa Pro Tyr Asn Val Ala Ile Leu Leu Ser Ser Tyr Gln Ser Ile 
        275                 280                 285             


Leu Phe Gly Asn Asp Cys Glu Arg Ser Lys His Leu Asp Leu Val Met 
    290                 295                 300                 


Leu Val Xaa Glu Val Ile Ala Tyr Ser His Cys Cys Met Asn Pro Val 
305                 310                 315                 320 


Ile Tyr Ala Phe Val Gly Glu Arg Phe Arg Lys Tyr Leu Arg His Phe 
                325                 330                 335     


Phe His Arg His Leu Leu Met His Leu Gly Arg Tyr Ile Pro Phe Leu 
            340                 345                 350         


Pro Ser Glu Lys Leu Glu Arg Xaa Ser Ser Val Ser Pro Ser Xaa Ala 
        355                 360                 365             


Glu Pro Glu Leu Ser Ile Val Phe 
    370                 375     


<210> 5332
<211> 21
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(14)
<223> Selenocysteine

<400> 5332
Met Xaa Xaa Ser Leu Asp Xaa Val Glu Xaa Phe Gly Xaa Xaa Ser Tyr 
1               5                   10                  15      


Tyr Asp Asp Val Gly 
            20      


<210> 5333
<211> 80
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<400> 5333
Met Xaa Xaa Ser Leu Asp Xaa Val Glu Xaa Phe Gly Xaa Xaa Ser Tyr 
1               5                   10                  15      


Tyr Asp Asp Val Gly Leu Leu Cys Glu Lys Ala Asp Xaa Arg Ala Leu 
            20                  25                  30          


Met Ala Gln Phe Val Pro Pro Leu Tyr Ser Leu Val Phe Xaa Val Gly 
        35                  40                  45              


Leu Leu Gly Asn Val Val Val Val Met Ile Leu Ile Lys Tyr Arg Arg 
    50                  55                  60                  


Leu Arg Ile Met Xaa Asn Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


<210> 5334
<211> 355
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<400> 5334
Met Xaa Xaa Ser Leu Asp Xaa Val Glu Xaa Phe Gly Xaa Xaa Ser Tyr 
1               5                   10                  15      


Tyr Asp Asp Val Gly Leu Leu Cys Glu Lys Ala Asp Xaa Arg Ala Leu 
            20                  25                  30          


Met Ala Gln Phe Val Pro Pro Leu Tyr Ser Leu Val Phe Xaa Val Gly 
        35                  40                  45              


Leu Leu Gly Asn Val Val Val Val Met Ile Leu Ile Lys Tyr Arg Arg 
    50                  55                  60                  


Leu Arg Ile Met Xaa Asn Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


Leu Leu Phe Leu Val Xaa Leu Pro Phe Trp Ile His Tyr Val Arg Gly 
                85                  90                  95      


His Asn Trp Val Phe Gly His Gly Met Cys Lys Leu Leu Ser Gly Phe 
            100                 105                 110         


Tyr His Xaa Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Xaa 
        115                 120                 125             


Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala 
    130                 135                 140                 


Arg Xaa Val Xaa Phe Gly Val Ile Xaa Ser Ile Val Xaa Trp Gly Leu 
145                 150                 155                 160 


Ala Val Leu Ala Ala Leu Pro Glu Phe Ile Phe Tyr Glu Xaa Glu Glu 
                165                 170                 175     


Leu Phe Glu Glu Xaa Leu Cys Ser Ala Leu Tyr Pro Glu Asp Xaa Val 
            180                 185                 190         


Tyr Ser Trp Arg His Phe His Xaa Leu Arg Met Xaa Ile Phe Cys Leu 
        195                 200                 205             


Val Leu Pro Leu Leu Val Met Ala Ile Cys Tyr Xaa Gly Ile Ile Lys 
    210                 215                 220                 


Xaa Leu Leu Arg Cys Pro Ser Lys Lys Lys Tyr Lys Ala Ile Arg Leu 
225                 230                 235                 240 


Ile Phe Val Ile Met Ala Val Phe Phe Ile Phe Trp Xaa Pro Tyr Asn 
                245                 250                 255     


Val Ala Ile Leu Leu Ser Ser Tyr Gln Ser Ile Leu Phe Gly Asn Asp 
            260                 265                 270         


Cys Glu Arg Ser Lys His Leu Asp Leu Val Met Leu Val Xaa Glu Val 
        275                 280                 285             


Ile Ala Tyr Ser His Cys Cys Met Asn Pro Val Ile Tyr Ala Phe Val 
    290                 295                 300                 


Gly Glu Arg Phe Arg Lys Tyr Leu Arg His Phe Phe His Arg His Leu 
305                 310                 315                 320 


Leu Met His Leu Gly Arg Tyr Ile Pro Phe Leu Pro Ser Glu Lys Leu 
                325                 330                 335     


Glu Arg Xaa Ser Ser Val Ser Pro Ser Xaa Ala Glu Pro Glu Leu Ser 
            340                 345                 350         


Ile Val Phe 
        355 


<210> 5335
<211> 360
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<400> 5335
Met Asn Pro Xaa Asp Ile Ala Asp Xaa Xaa Leu Asp Glu Ser Ile Tyr 
1               5                   10                  15      


Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro Cys Xaa Lys Glu 
            20                  25                  30          


Gly Ile Lys Ala Phe Gly Glu Leu Phe Leu Pro Pro Leu Tyr Ser Leu 
        35                  40                  45              


Val Phe Val Phe Gly Leu Leu Gly Asn Ser Val Val Val Leu Val Leu 
    50                  55                  60                  


Phe Lys Tyr Lys Arg Leu Arg Ser Met Xaa Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Ile Ser Asp Leu Leu Phe Val Phe Ser Leu Pro Phe Trp Gly 
                85                  90                  95      


Tyr Tyr Ala Ala Asp Gln Trp Val Phe Gly Leu Gly Leu Cys Lys Met 
            100                 105                 110         


Ile Ser Trp Met Tyr Leu Val Gly Phe Tyr Ser Gly Ile Phe Phe Val 
        115                 120                 125             


Met Leu Met Ser Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe 
    130                 135                 140                 


Ser Leu Arg Ala Arg Xaa Leu Xaa Tyr Gly Val Ile Xaa Ser Leu Ala 
145                 150                 155                 160 


Xaa Trp Ser Val Ala Val Phe Ala Ser Leu Pro Gly Phe Leu Phe Ser 
                165                 170                 175     


Xaa Cys Tyr Xaa Glu Arg Asn His Xaa Tyr Cys Lys Xaa Lys Tyr Ser 
            180                 185                 190         


Leu Asn Ser Xaa Xaa Trp Lys Val Leu Ser Ser Leu Glu Ile Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Ile Pro Leu Gly Ile Met Leu Phe Cys Tyr Ser Met 
    210                 215                 220                 


Ile Ile Arg Xaa Leu Gln His Cys Lys Asn Glu Lys Lys Asn Lys Ala 
225                 230                 235                 240 


Val Lys Met Ile Phe Ala Val Val Val Leu Phe Leu Gly Phe Trp Xaa 
                245                 250                 255     


Pro Tyr Asn Ile Val Leu Phe Leu Glu Xaa Leu Val Glu Leu Glu Val 
            260                 265                 270         


Leu Gln Asp Cys Xaa Phe Glu Arg Tyr Leu Asp Tyr Ala Ile Gln Ala 
        275                 280                 285             


Xaa Glu Xaa Leu Ala Phe Val His Cys Cys Leu Asn Pro Ile Ile Tyr 
    290                 295                 300                 


Phe Phe Leu Gly Glu Lys Phe Arg Lys Tyr Ile Leu Gln Leu Phe Lys 
305                 310                 315                 320 


Xaa Cys Arg Gly Leu Phe Val Leu Cys Gln Tyr Cys Gly Leu Leu Gln 
                325                 330                 335     


Ile Tyr Ser Ala Asp Xaa Pro Ser Ser Ser Tyr Xaa Gln Ser Xaa Met 
            340                 345                 350         


Asp His Asp Leu His Asp Ala Leu 
        355                 360 


<210> 5336
<211> 352
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<400> 5336
Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Xaa 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Xaa Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu 
65                  70                  75                  80  


Leu Xaa Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Xaa Met Cys Gln Leu Leu Xaa Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Xaa Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Xaa Val Xaa Phe 
    130                 135                 140                 


Gly Val Val Xaa Ser Val Ile Xaa Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Xaa Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Xaa Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Xaa Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Xaa Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Xaa Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Xaa Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Xaa Glu Xaa Leu Gly Met Xaa 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Xaa Arg Ser Xaa Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210> 5337
<211> 374
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<400> 5337
Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Xaa Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Leu Val Val Ile Xaa Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Xaa Asp Val Tyr Leu Leu Asn Met Ala Ile Ala Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Xaa Leu Pro Phe Trp Ala Val Ser His Ala Xaa Gly Ala Trp Val 
            100                 105                 110         


Phe Ser Asn Ala Xaa Cys Lys Leu Leu Lys Gly Ile Tyr Ala Ile Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Xaa Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Xaa Lys Ser Phe Arg Leu Arg Ser Arg Xaa 
145                 150                 155                 160 


Leu Pro Arg Ser Lys Ile Ile Cys Leu Val Val Trp Gly Leu Ser Val 
                165                 170                 175     


Ile Ile Ser Ser Ser Xaa Phe Val Phe Asn Gln Lys Tyr Asn Xaa Gln 
            180                 185                 190         


Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Xaa Val Ser Glu Pro Ile 
        195                 200                 205             


Arg Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Leu Phe Gly Phe Phe 
    210                 215                 220                 


Ile Pro Leu Met Phe Met Ile Phe Cys Tyr Xaa Phe Ile Val Lys Xaa 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Val Ile 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Xaa Ala Ala Asn Leu Gly Lys Met Asn Arg Ser Cys 
        275                 280                 285             


Gln Ser Glu Lys Leu Ile Gly Tyr Xaa Lys Xaa Val Xaa Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Leu Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Xaa Ser Glu Xaa Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Xaa Met 
    370                 


<210> 5338
<211> 378
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(375)
<223> Selenocysteine

<400> 5338
Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Xaa Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Xaa Xaa Val Asp Tyr Xaa Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Xaa Tyr Ile Tyr Phe Lys Arg Leu Lys Xaa Met Xaa Asp Xaa Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Xaa Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Xaa Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Xaa Glu His Val Glu Ala Phe Ile Xaa Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Xaa Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Xaa Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Xaa Ser Ser Xaa Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Xaa Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Xaa Xaa Xaa Xaa Phe Ser Pro 
    370                 375             


<210> 5339
<211> 372
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(369)
<223> Selenocysteine

<400> 5339
Met Lys Ser Val Leu Val Val Ala Leu Leu Val Ile Phe Gln Val Cys 
1               5                   10                  15      


Leu Cys Gln Asp Glu Val Xaa Asp Asp Tyr Ile Gly Asp Asn Xaa Xaa 
            20                  25                  30          


Val Asp Tyr Xaa Leu Phe Glu Ser Leu Cys Ser Lys Lys Asp Val Arg 
        35                  40                  45              


Asn Phe Lys Ala Trp Phe Leu Pro Ile Met Tyr Ser Ile Ile Cys Phe 
    50                  55                  60                  


Val Gly Leu Leu Gly Asn Gly Leu Val Val Leu Xaa Tyr Ile Tyr Phe 
65                  70                  75                  80  


Lys Arg Leu Lys Xaa Met Xaa Asp Xaa Tyr Leu Leu Asn Leu Ala Val 
                85                  90                  95      


Ala Asp Ile Leu Phe Leu Leu Xaa Leu Pro Phe Trp Ala Tyr Ser Ala 
            100                 105                 110         


Ala Lys Ser Trp Val Phe Gly Val His Phe Cys Lys Leu Ile Phe Ala 
        115                 120                 125             


Ile Tyr Lys Met Ser Phe Phe Ser Gly Met Leu Leu Leu Leu Cys Ile 
    130                 135                 140                 


Ser Ile Asp Arg Tyr Val Ala Ile Val Gln Ala Val Ser Ala His Arg 
145                 150                 155                 160 


His Arg Ala Arg Val Leu Leu Ile Ser Lys Leu Ser Cys Val Gly Ile 
                165                 170                 175     


Trp Ile Leu Ala Xaa Val Leu Ser Ile Pro Glu Leu Leu Tyr Ser Asp 
            180                 185                 190         


Leu Gln Arg Ser Ser Ser Glu Gln Ala Met Arg Cys Ser Leu Ile Xaa 
        195                 200                 205             


Glu His Val Glu Ala Phe Ile Xaa Ile Gln Val Ala Gln Met Val Ile 
    210                 215                 220                 


Gly Phe Leu Val Pro Leu Leu Ala Met Ser Phe Cys Tyr Leu Val Ile 
225                 230                 235                 240 


Ile Arg Xaa Leu Leu Gln Ala Arg Asn Phe Glu Arg Asn Lys Ala Ile 
                245                 250                 255     


Lys Val Ile Ile Ala Val Val Val Val Phe Ile Val Phe Gln Leu Pro 
            260                 265                 270         


Tyr Asn Gly Val Val Leu Ala Gln Xaa Val Ala Asn Phe Asn Ile Xaa 
        275                 280                 285             


Ser Ser Xaa Cys Glu Leu Ser Lys Gln Leu Asn Ile Ala Tyr Asp Val 
    290                 295                 300                 


Xaa Tyr Ser Leu Ala Cys Val Arg Cys Cys Val Asn Pro Phe Leu Tyr 
305                 310                 315                 320 


Ala Phe Ile Gly Val Lys Phe Arg Asn Asp Leu Phe Lys Leu Phe Lys 
                325                 330                 335     


Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu Arg Gln Trp Ser Ser Cys 
            340                 345                 350         


Arg His Ile Arg Arg Ser Ser Met Ser Val Glu Ala Glu Xaa Xaa Xaa 
        355                 360                 365             


Xaa Phe Ser Pro 
    370         


<210> 5340
<211> 199
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<400> 5340
Met Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val 
1               5                   10                  15      


Val Leu Xaa Tyr Ile Tyr Phe Lys Arg Leu Lys Xaa Met Xaa Asp Xaa 
            20                  25                  30          


Tyr Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Xaa Leu 
        35                  40                  45              


Pro Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His 
    50                  55                  60                  


Phe Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly 
65                  70                  75                  80  


Met Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val 
                85                  90                  95      


Gln Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser 
            100                 105                 110         


Lys Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Xaa Val Leu Ser Ile 
        115                 120                 125             


Pro Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala 
    130                 135                 140                 


Met Arg Cys Ser Leu Ile Xaa Glu His Val Glu Ala Phe Ile Xaa Ile 
145                 150                 155                 160 


Gln Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met 
                165                 170                 175     


Ser Phe Cys Tyr Leu Val Ile Ile Arg Xaa Leu Leu Gln Ala Arg Asn 
            180                 185                 190         


Phe Glu Arg Asn Lys Ala Ile 
        195                 


<210> 5341
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<400> 5341
Met Asp Tyr Xaa Leu Asp Leu Ser Val Xaa Xaa Val Xaa Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ile Phe Ser Ser Pro Cys Asp Ala Glu Leu Ile Gln Xaa 
            20                  25                  30          


Asn Asp Leu Leu Ser Ala Gly Pro Val Gly Val Trp Asp Cys Asn Val 
        35                  40                  45              


Gln Ser Gly Val Trp Leu Leu Leu His Trp Leu Leu Gln Gln His Val 
    50                  55                  60                  


Phe His His Pro His Glu Cys Gly Gln Val Pro Gly Cys Cys Pro Cys 
65                  70                  75                  80  


Arg Val Cys Pro Lys Gly Glu Asp Asp Gln Asp Gly His Asn Ala Val 
                85                  90                  95      


Pro Gly Ser Met Ala Asn Arg His Tyr Gly Tyr His Pro Ile Ala Ser 
            100                 105                 110         


Val Leu Pro Ser Gly Leu 
        115             


<210> 5342
<211> 355
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<400> 5342
Met Asp Tyr Xaa Leu Asp Leu Ser Val Xaa Xaa Val Xaa Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ile Phe Ser Ser Pro Cys Asp Ala Glu Leu Ile Gln Xaa 
            20                  25                  30          


Asn Gly Lys Leu Leu Leu Ala Val Phe Tyr Cys Leu Leu Phe Val Phe 
        35                  40                  45              


Ser Leu Leu Gly Asn Ser Leu Val Ile Leu Val Leu Val Val Cys Lys 
    50                  55                  60                  


Lys Leu Arg Ser Ile Xaa Asp Val Tyr Leu Leu Asn Leu Ala Leu Ser 
65                  70                  75                  80  


Asp Leu Leu Phe Val Phe Ser Phe Pro Phe Gln Xaa Tyr Tyr Leu Leu 
                85                  90                  95      


Asp Gln Trp Val Phe Gly Xaa Val Met Cys Lys Val Val Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Ile Gly Phe Tyr Ser Ser Met Phe Phe Ile Xaa Leu Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Leu Ala Val Val His Ala Val Tyr Ala Leu Lys Val 
    130                 135                 140                 


Arg Xaa Ile Arg Met Gly Xaa Xaa Leu Cys Leu Ala Val Trp Leu Xaa 
145                 150                 155                 160 


Ala Ile Met Ala Xaa Ile Pro Leu Leu Val Phe Tyr Gln Val Ala Ser 
                165                 170                 175     


Glu Asp Gly Val Leu Gln Cys Tyr Ser Phe Tyr Asn Gln Gln Xaa Leu 
            180                 185                 190         


Lys Trp Lys Ile Phe Xaa Asn Phe Lys Met Asn Ile Leu Gly Leu Leu 
        195                 200                 205             


Ile Pro Phe Xaa Ile Phe Met Phe Cys Tyr Ile Lys Ile Leu His Gln 
    210                 215                 220                 


Leu Lys Arg Cys Gln Asn His Asn Lys Xaa Lys Ala Ile Arg Leu Val 
225                 230                 235                 240 


Leu Ile Val Val Ile Ala Ser Leu Leu Phe Trp Val Pro Phe Asn Val 
                245                 250                 255     


Val Leu Phe Leu Xaa Ser Leu His Ser Met His Ile Leu Asp Gly Cys 
            260                 265                 270         


Ser Ile Ser Gln Gln Leu Xaa Tyr Ala Xaa His Val Xaa Glu Ile Ile 
        275                 280                 285             


Ser Phe Xaa His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val Gly 
    290                 295                 300                 


Glu Lys Phe Lys Lys His Leu Ser Glu Ile Phe Gln Lys Ser Cys Ser 
305                 310                 315                 320 


Gln Ile Phe Asn Tyr Leu Gly Arg Gln Met Pro Arg Glu Ser Cys Glu 
                325                 330                 335     


Lys Ser Ser Ser Cys Gln Gln His Ser Ser Arg Ser Ser Ser Val Asp 
            340                 345                 350         


Tyr Ile Leu 
        355 


<210> 5343
<211> 357
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(351)
<223> Selenocysteine

<400> 5343
Met Ala Asp Asp Tyr Gly Ser Glu Ser Xaa Ser Ser Met Glu Asp Tyr 
1               5                   10                  15      


Val Asn Phe Asn Phe Xaa Asp Phe Tyr Cys Glu Lys Asn Asn Val Arg 
            20                  25                  30          


Gln Phe Ala Ser His Phe Leu Pro Pro Leu Tyr Trp Leu Val Phe Ile 
        35                  40                  45              


Val Gly Ala Leu Gly Asn Ser Leu Val Ile Leu Val Tyr Trp Tyr Cys 
    50                  55                  60                  


Xaa Arg Val Lys Xaa Met Xaa Asp Met Phe Leu Leu Asn Leu Ala Ile 
65                  70                  75                  80  


Ala Asp Leu Leu Phe Leu Val Xaa Leu Pro Phe Trp Ala Ile Ala Ala 
                85                  90                  95      


Ala Asp Gln Trp Lys Phe Gln Xaa Phe Met Cys Lys Val Val Asn Ser 
            100                 105                 110         


Met Tyr Lys Met Asn Phe Tyr Ser Cys Val Leu Leu Ile Met Cys Ile 
        115                 120                 125             


Ser Val Asp Arg Tyr Ile Ala Ile Ala Gln Ala Met Arg Ala His Xaa 
    130                 135                 140                 


Trp Arg Glu Lys Arg Leu Leu Tyr Ser Lys Met Val Cys Phe Xaa Ile 
145                 150                 155                 160 


Trp Val Leu Ala Ala Ala Leu Cys Ile Pro Glu Ile Leu Tyr Ser Gln 
                165                 170                 175     


Ile Lys Glu Glu Ser Gly Ile Ala Ile Cys Xaa Met Val Tyr Pro Ser 
            180                 185                 190         


Asp Glu Ser Xaa Lys Leu Lys Ser Ala Val Leu Xaa Leu Lys Val Ile 
        195                 200                 205             


Leu Gly Phe Phe Leu Pro Phe Val Val Met Ala Cys Cys Tyr Xaa Ile 
    210                 215                 220                 


Ile Ile His Xaa Leu Ile Gln Ala Lys Lys Ser Ser Lys His Lys Ala 
225                 230                 235                 240 


Leu Lys Val Xaa Ile Xaa Val Leu Xaa Val Phe Val Leu Ser Gln Phe 
                245                 250                 255     


Pro Tyr Asn Cys Ile Leu Leu Val Gln Xaa Ile Asp Ala Tyr Ala Met 
            260                 265                 270         


Phe Ile Ser Asn Cys Ala Val Ser Xaa Asn Ile Asp Ile Cys Phe Gln 
        275                 280                 285             


Val Xaa Gln Xaa Ile Ala Phe Phe His Ser Cys Leu Asn Pro Val Leu 
    290                 295                 300                 


Tyr Val Phe Val Gly Glu Arg Phe Arg Arg Asp Leu Val Lys Xaa Leu 
305                 310                 315                 320 


Lys Asn Leu Gly Cys Ile Ser Gln Ala Gln Trp Val Ser Phe Xaa Arg 
                325                 330                 335     


Arg Glu Gly Ser Leu Lys Leu Ser Ser Met Leu Leu Glu Xaa Xaa Ser 
            340                 345                 350         


Gly Ala Leu Ser Leu 
        355         


<210> 5344
<211> 369
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(363)
<223> Selenocysteine

<400> 5344
Met Xaa Pro Xaa Asp Phe Xaa Ser Pro Ile Pro Asn Met Ala Asp Asp 
1               5                   10                  15      


Tyr Gly Ser Glu Ser Xaa Ser Ser Met Glu Asp Tyr Val Asn Phe Asn 
            20                  25                  30          


Phe Xaa Asp Phe Tyr Cys Glu Lys Asn Asn Val Arg Gln Phe Ala Ser 
        35                  40                  45              


His Phe Leu Pro Pro Leu Tyr Trp Leu Val Phe Ile Val Gly Ala Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Ile Leu Val Tyr Trp Tyr Cys Xaa Arg Val Lys 
65                  70                  75                  80  


Xaa Met Xaa Asp Met Phe Leu Leu Asn Leu Ala Ile Ala Asp Leu Leu 
                85                  90                  95      


Phe Leu Val Xaa Leu Pro Phe Trp Ala Ile Ala Ala Ala Asp Gln Trp 
            100                 105                 110         


Lys Phe Gln Xaa Phe Met Cys Lys Val Val Asn Ser Met Tyr Lys Met 
        115                 120                 125             


Asn Phe Tyr Ser Cys Val Leu Leu Ile Met Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Ile Ala Ile Ala Gln Ala Met Arg Ala His Xaa Trp Arg Glu Lys 
145                 150                 155                 160 


Arg Leu Leu Tyr Ser Lys Met Val Cys Phe Xaa Ile Trp Val Leu Ala 
                165                 170                 175     


Ala Ala Leu Cys Ile Pro Glu Ile Leu Tyr Ser Gln Ile Lys Glu Glu 
            180                 185                 190         


Ser Gly Ile Ala Ile Cys Xaa Met Val Tyr Pro Ser Asp Glu Ser Xaa 
        195                 200                 205             


Lys Leu Lys Ser Ala Val Leu Xaa Leu Lys Val Ile Leu Gly Phe Phe 
    210                 215                 220                 


Leu Pro Phe Val Val Met Ala Cys Cys Tyr Xaa Ile Ile Ile His Xaa 
225                 230                 235                 240 


Leu Ile Gln Ala Lys Lys Ser Ser Lys His Lys Ala Leu Lys Val Xaa 
                245                 250                 255     


Ile Xaa Val Leu Xaa Val Phe Val Leu Ser Gln Phe Pro Tyr Asn Cys 
            260                 265                 270         


Ile Leu Leu Val Gln Xaa Ile Asp Ala Tyr Ala Met Phe Ile Ser Asn 
        275                 280                 285             


Cys Ala Val Ser Xaa Asn Ile Asp Ile Cys Phe Gln Val Xaa Gln Xaa 
    290                 295                 300                 


Ile Ala Phe Phe His Ser Cys Leu Asn Pro Val Leu Tyr Val Phe Val 
305                 310                 315                 320 


Gly Glu Arg Phe Arg Arg Asp Leu Val Lys Xaa Leu Lys Asn Leu Gly 
                325                 330                 335     


Cys Ile Ser Gln Ala Gln Trp Val Ser Phe Xaa Arg Arg Glu Gly Ser 
            340                 345                 350         


Leu Lys Leu Ser Ser Met Leu Leu Glu Xaa Xaa Ser Gly Ala Leu Ser 
        355                 360                 365             


Leu 
    


<210> 5345
<211> 107
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<400> 5345
Met Xaa Pro Xaa Asp Phe Xaa Ser Pro Pro Gly Pro Ala Pro Asp His 
1               5                   10                  15      


Leu Pro Ser Leu Ala Gln Glu Ser Ile Ser Phe Gln Asp Leu Ser Pro 
            20                  25                  30          


Gly Leu Xaa Gln Ala Leu Phe Leu Xaa Trp Leu Met Xaa Met Ala Leu 
        35                  40                  45              


Asn Pro His Leu Pro Trp Lys Xaa Xaa Leu Xaa Ser Xaa Ser Leu Xaa 
    50                  55                  60                  


Ser Xaa Val Arg Lys Xaa Met Ser Gly Ser Leu Arg Ala Ile Ser Ser 
65                  70                  75                  80  


His Pro Cys Xaa Gly Ser Cys Ser Ser Trp Val Pro Trp Ala Xaa Val 
                85                  90                  95      


Leu Leu Ser Leu Ser Xaa Gly Xaa Ala Gln Glu 
            100                 105         


<210> 5346
<211> 217
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<400> 5346
Met Ala Asn Tyr Xaa Leu Ala Pro Glu Asp Glu Tyr Asp Val Leu Ile 
1               5                   10                  15      


Glu Gly Glu Leu Glu Ser Asp Glu Ala Glu Gln Cys Asp Lys Tyr Asp 
            20                  25                  30          


Ala Gln Ala Leu Ser Ala Gln Leu Val Pro Ser Leu Cys Ser Ala Val 
        35                  40                  45              


Phe Val Ile Gly Val Leu Asp Asn Leu Leu Val Val Leu Ile Leu Val 
    50                  55                  60                  


Lys Tyr Lys Gly Leu Lys Arg Val Glu Asn Ile Tyr Leu Leu Asn Leu 
65                  70                  75                  80  


Ala Val Ser Asn Leu Cys Phe Leu Leu Xaa Leu Pro Phe Trp Ala His 
                85                  90                  95      


Ala Gly Gly Asp Pro Met Cys Lys Ile Leu Ile Gly Leu Tyr Phe Val 
            100                 105                 110         


Gly Leu Tyr Ser Glu Xaa Phe Phe Asn Cys Leu Leu Xaa Val Gln Arg 
        115                 120                 125             


Tyr Leu Val Phe Leu His Lys Gly Asn Phe Phe Ser Ala Arg Arg Arg 
    130                 135                 140                 


Val Pro Cys Gly Ile Ile Xaa Ser Val Leu Ala Trp Val Xaa Ala Ile 
145                 150                 155                 160 


Leu Ala Xaa Leu Pro Glu Phe Val Val Tyr Lys Pro Gln Met Glu Asp 
                165                 170                 175     


Gln Lys Tyr Lys Cys Ala Phe Ser Arg Xaa Pro Phe Leu Pro Ala Asp 
            180                 185                 190         


Glu Xaa Phe Trp Lys His Phe Leu Xaa Leu Lys Met Asn Ile Ser Val 
        195                 200                 205             


Leu Val Leu Pro Leu Phe Ile Phe Xaa 
    210                 215         


<210> 5347
<211> 344
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<400> 5347
Met Ala Asn Tyr Xaa Leu Ala Pro Glu Asp Glu Tyr Asp Val Leu Ile 
1               5                   10                  15      


Glu Gly Glu Leu Glu Ser Asp Glu Ala Glu Gln Cys Asp Lys Tyr Asp 
            20                  25                  30          


Ala Gln Ala Leu Ser Ala Gln Leu Val Pro Ser Leu Cys Ser Ala Val 
        35                  40                  45              


Phe Val Ile Gly Val Leu Asp Asn Leu Leu Val Val Leu Ile Leu Val 
    50                  55                  60                  


Lys Tyr Lys Gly Leu Lys Arg Val Glu Asn Ile Tyr Leu Leu Asn Leu 
65                  70                  75                  80  


Ala Val Ser Asn Leu Cys Phe Leu Leu Xaa Leu Pro Phe Trp Ala His 
                85                  90                  95      


Ala Gly Gly Asp Pro Met Cys Lys Ile Leu Ile Gly Leu Tyr Phe Val 
            100                 105                 110         


Gly Leu Tyr Ser Glu Xaa Phe Phe Asn Cys Leu Leu Xaa Val Gln Arg 
        115                 120                 125             


Tyr Leu Val Phe Leu His Lys Gly Asn Phe Phe Ser Ala Arg Arg Arg 
    130                 135                 140                 


Val Pro Cys Gly Ile Ile Xaa Ser Val Leu Ala Trp Val Xaa Ala Ile 
145                 150                 155                 160 


Leu Ala Xaa Leu Pro Glu Phe Val Val Tyr Lys Pro Gln Met Glu Asp 
                165                 170                 175     


Gln Lys Tyr Lys Cys Ala Phe Ser Arg Xaa Pro Phe Leu Pro Ala Asp 
            180                 185                 190         


Glu Xaa Phe Trp Lys His Phe Leu Xaa Leu Lys Met Asn Ile Ser Val 
        195                 200                 205             


Leu Val Leu Pro Leu Phe Ile Phe Xaa Phe Leu Tyr Val Gln Met Arg 
    210                 215                 220                 


Lys Xaa Leu Arg Phe Arg Glu Gln Arg Tyr Ser Leu Phe Lys Leu Val 
225                 230                 235                 240 


Phe Ala Ile Met Val Val Phe Leu Leu Met Trp Ala Pro Tyr Asn Ile 
                245                 250                 255     


Ala Phe Phe Leu Ser Xaa Phe Lys Glu His Phe Ser Leu Ser Asp Cys 
            260                 265                 270         


Lys Ser Ser Tyr Asn Leu Asp Lys Ser Val His Ile Xaa Lys Leu Ile 
        275                 280                 285             


Ala Xaa Xaa His Cys Cys Ile Asn Pro Leu Leu Tyr Ala Phe Leu Asp 
    290                 295                 300                 


Gly Xaa Phe Ser Lys Tyr Leu Cys Arg Cys Phe His Leu Arg Ser Asn 
305                 310                 315                 320 


Xaa Pro Leu Gln Pro Arg Gly Gln Ser Ala Gln Gly Xaa Ser Arg Glu 
                325                 330                 335     


Glu Pro Asp His Ser Xaa Glu Val 
            340                 


<210> 5348
<211> 356
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<400> 5348
Met Ile Tyr Xaa Arg Phe Leu Lys Gly Ser Leu Lys Met Ala Asn Tyr 
1               5                   10                  15      


Xaa Leu Ala Pro Glu Asp Glu Tyr Asp Val Leu Ile Glu Gly Glu Leu 
            20                  25                  30          


Glu Ser Asp Glu Ala Glu Gln Cys Asp Lys Tyr Asp Ala Gln Ala Leu 
        35                  40                  45              


Ser Ala Gln Leu Val Pro Ser Leu Cys Ser Ala Val Phe Val Ile Gly 
    50                  55                  60                  


Val Leu Asp Asn Leu Leu Val Val Leu Ile Leu Val Lys Tyr Lys Gly 
65                  70                  75                  80  


Leu Lys Arg Val Glu Asn Ile Tyr Leu Leu Asn Leu Ala Val Ser Asn 
                85                  90                  95      


Leu Cys Phe Leu Leu Xaa Leu Pro Phe Trp Ala His Ala Gly Gly Asp 
            100                 105                 110         


Pro Met Cys Lys Ile Leu Ile Gly Leu Tyr Phe Val Gly Leu Tyr Ser 
        115                 120                 125             


Glu Xaa Phe Phe Asn Cys Leu Leu Xaa Val Gln Arg Tyr Leu Val Phe 
    130                 135                 140                 


Leu His Lys Gly Asn Phe Phe Ser Ala Arg Arg Arg Val Pro Cys Gly 
145                 150                 155                 160 


Ile Ile Xaa Ser Val Leu Ala Trp Val Xaa Ala Ile Leu Ala Xaa Leu 
                165                 170                 175     


Pro Glu Phe Val Val Tyr Lys Pro Gln Met Glu Asp Gln Lys Tyr Lys 
            180                 185                 190         


Cys Ala Phe Ser Arg Xaa Pro Phe Leu Pro Ala Asp Glu Xaa Phe Trp 
        195                 200                 205             


Lys His Phe Leu Xaa Leu Lys Met Asn Ile Ser Val Leu Val Leu Pro 
    210                 215                 220                 


Leu Phe Ile Phe Xaa Phe Leu Tyr Val Gln Met Arg Lys Xaa Leu Arg 
225                 230                 235                 240 


Phe Arg Glu Gln Arg Tyr Ser Leu Phe Lys Leu Val Phe Ala Ile Met 
                245                 250                 255     


Val Val Phe Leu Leu Met Trp Ala Pro Tyr Asn Ile Ala Phe Phe Leu 
            260                 265                 270         


Ser Xaa Phe Lys Glu His Phe Ser Leu Ser Asp Cys Lys Ser Ser Tyr 
        275                 280                 285             


Asn Leu Asp Lys Ser Val His Ile Xaa Lys Leu Ile Ala Xaa Xaa His 
    290                 295                 300                 


Cys Cys Ile Asn Pro Leu Leu Tyr Ala Phe Leu Asp Gly Xaa Phe Ser 
305                 310                 315                 320 


Lys Tyr Leu Cys Arg Cys Phe His Leu Arg Ser Asn Xaa Pro Leu Gln 
                325                 330                 335     


Pro Arg Gly Gln Ser Ala Gln Gly Xaa Ser Arg Glu Glu Pro Asp His 
            340                 345                 350         


Ser Xaa Glu Val 
        355     


<210> 5349
<211> 1021
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1009)
<223> Selenocysteine

<400> 5349
Met Ala Gly Ile Ser Tyr Val Ala Ser Phe Phe Leu Leu Leu Xaa Lys 
1               5                   10                  15      


Leu Ser Ile Gly Gln Arg Glu Val Xaa Val Gln Lys Gly Pro Leu Phe 
            20                  25                  30          


Arg Ala Glu Gly Tyr Pro Val Ser Ile Gly Cys Asn Val Xaa Gly His 
        35                  40                  45              


Gln Gly Pro Ser Glu Gln His Phe Gln Trp Ser Val Tyr Leu Pro Xaa 
    50                  55                  60                  


Asn Pro Xaa Gln Glu Val Gln Ile Ile Ser Xaa Lys Asp Ala Ala Phe 
65                  70                  75                  80  


Ser Tyr Ala Val Tyr Xaa Gln Arg Val Arg Ser Gly Asp Val Tyr Val 
                85                  90                  95      


Glu Arg Val Gln Gly Asn Ser Val Leu Leu His Ile Ser Lys Leu Gln 
            100                 105                 110         


Met Lys Asp Ala Gly Glu Tyr Glu Cys His Xaa Pro Asn Xaa Asp Glu 
        115                 120                 125             


Lys Tyr Tyr Gly Ser Tyr Ser Ala Lys Xaa Asn Leu Ile Val Ile Pro 
    130                 135                 140                 


Asp Xaa Leu Ser Ala Xaa Met Ser Ser Gln Xaa Leu Gly Lys Glu Glu 
145                 150                 155                 160 


Gly Glu Pro Leu Ala Leu Xaa Cys Glu Ala Ser Lys Ala Xaa Ala Gln 
                165                 170                 175     


His Xaa His Leu Ser Val Xaa Trp Tyr Leu Xaa Gln Asp Gly Gly Gly 
            180                 185                 190         


Ser Gln Ala Xaa Glu Ile Ile Ser Leu Ser Lys Asp Phe Ile Leu Val 
        195                 200                 205             


Pro Gly Pro Leu Tyr Xaa Glu Arg Phe Ala Ala Ser Asp Val Gln Leu 
    210                 215                 220                 


Asn Lys Leu Gly Pro Xaa Xaa Phe Arg Leu Ser Ile Glu Arg Leu Gln 
225                 230                 235                 240 


Ser Ser Asp Gln Gly Gln Leu Phe Cys Glu Ala Xaa Glu Trp Ile Gln 
                245                 250                 255     


Asp Pro Asp Glu Xaa Trp Met Phe Ile Xaa Lys Lys Gln Xaa Asp Gln 
            260                 265                 270         


Xaa Xaa Leu Arg Ile Gln Pro Ala Val Lys Asp Phe Gln Val Asn Ile 
        275                 280                 285             


Xaa Ala Asp Ser Leu Phe Ala Glu Gly Lys Pro Leu Glu Leu Val Cys 
    290                 295                 300                 


Leu Val Val Ser Ser Gly Arg Asp Pro Gln Leu Gln Gly Ile Trp Phe 
305                 310                 315                 320 


Phe Asn Gly Xaa Glu Ile Ala His Ile Asp Ala Gly Gly Val Leu Gly 
                325                 330                 335     


Leu Lys Asn Asp Tyr Lys Glu Arg Ala Ser Gln Gly Glu Leu Gln Val 
            340                 345                 350         


Ser Lys Leu Gly Pro Lys Ala Phe Ser Leu Lys Ile Phe Ser Leu Gly 
        355                 360                 365             


Pro Glu Asp Glu Gly Ala Tyr Arg Cys Val Val Ala Glu Val Met Lys 
    370                 375                 380                 


Xaa Arg Xaa Gly Ser Trp Gln Val Leu Gln Arg Lys Gln Ser Pro Asp 
385                 390                 395                 400 


Ser His Val His Leu Arg Lys Pro Ala Ala Arg Ser Val Val Met Ser 
                405                 410                 415     


Xaa Lys Asn Lys Gln Gln Val Val Trp Glu Gly Glu Xaa Leu Ala Phe 
            420                 425                 430         


Leu Cys Lys Ala Gly Gly Ala Glu Ser Pro Leu Ser Val Ser Trp Trp 
        435                 440                 445             


His Ile Pro Arg Asp Gln Xaa Gln Pro Glu Phe Val Ala Gly Met Gly 
    450                 455                 460                 


Gln Asp Gly Ile Val Gln Leu Gly Ala Ser Tyr Gly Val Pro Ser Tyr 
465                 470                 475                 480 


His Gly Asn Xaa Arg Leu Glu Lys Met Asp Trp Ala Xaa Phe Gln Leu 
                485                 490                 495     


Glu Ile Xaa Phe Xaa Ala Ile Xaa Asp Ser Gly Xaa Tyr Glu Cys Arg 
            500                 505                 510         


Val Ser Glu Lys Ser Arg Asn Gln Ala Arg Asp Leu Ser Trp Xaa Gln 
        515                 520                 525             


Lys Ile Ser Val Xaa Val Lys Ser Leu Glu Ser Ser Leu Gln Val Ser 
    530                 535                 540                 


Leu Met Ser Arg Gln Pro Gln Val Met Leu Xaa Asn Xaa Phe Asp Leu 
545                 550                 555                 560 


Ser Cys Val Val Arg Ala Gly Tyr Ser Asp Leu Lys Val Pro Leu Xaa 
                565                 570                 575     


Val Xaa Trp Gln Phe Gln Pro Ala Ser Ser His Ile Phe His Gln Leu 
            580                 585                 590         


Ile Arg Ile Xaa His Asn Gly Xaa Ile Glu Trp Gly Asn Phe Leu Ser 
        595                 600                 605             


Arg Phe Gln Lys Lys Xaa Lys Val Ser Gln Ser Leu Phe Arg Ser Gln 
    610                 615                 620                 


Leu Leu Val His Asp Ala Xaa Glu Glu Glu Xaa Gly Val Tyr Gln Cys 
625                 630                 635                 640 


Glu Val Glu Val Tyr Asp Arg Asn Ser Leu Tyr Asn Asn Arg Pro Pro 
                645                 650                 655     


Arg Ala Ser Ala Ile Ser His Pro Leu Arg Ile Ala Val Xaa Leu Pro 
            660                 665                 670         


Glu Ser Lys Leu Lys Val Asn Ser Arg Ser Gln Val Gln Glu Leu Ser 
        675                 680                 685             


Ile Asn Ser Asn Xaa Asp Ile Glu Cys Ser Ile Leu Ser Arg Ser Asn 
    690                 695                 700                 


Gly Asn Leu Gln Leu Ala Ile Ile Trp Tyr Phe Ser Pro Val Ser Xaa 
705                 710                 715                 720 


Asn Ala Ser Trp Leu Lys Ile Leu Glu Met Asp Gln Xaa Asn Val Ile 
                725                 730                 735     


Lys Xaa Gly Asp Glu Phe His Xaa Pro Gln Arg Lys Gln Lys Phe His 
            740                 745                 750         


Xaa Glu Lys Val Ser Gln Asp Leu Phe Gln Leu His Ile Leu Asn Val 
        755                 760                 765             


Glu Asp Ser Asp Arg Gly Lys Tyr His Cys Ala Val Glu Glu Trp Leu 
    770                 775                 780                 


Leu Ser Xaa Asn Gly Xaa Trp His Lys Leu Gly Glu Lys Lys Ser Gly 
785                 790                 795                 800 


Leu Xaa Glu Leu Lys Leu Lys Pro Xaa Gly Ser Lys Val Arg Val Ser 
                805                 810                 815     


Lys Val Tyr Trp Xaa Glu Asn Val Xaa Glu His Arg Glu Val Ala Ile 
            820                 825                 830         


Arg Cys Ser Leu Glu Ser Val Gly Ser Ser Ala Xaa Leu Tyr Ser Val 
        835                 840                 845             


Met Trp Tyr Trp Asn Arg Glu Asn Ser Gly Ser Lys Leu Leu Val His 
    850                 855                 860                 


Leu Gln His Asp Gly Leu Leu Glu Tyr Gly Glu Glu Gly Leu Arg Arg 
865                 870                 875                 880 


His Leu His Cys Tyr Arg Ser Ser Ser Xaa Asp Phe Val Leu Lys Leu 
                885                 890                 895     


His Gln Val Glu Met Glu Asp Ala Gly Met Tyr Trp Cys Arg Val Ala 
            900                 905                 910         


Glu Trp Gln Leu His Gly His Pro Ser Lys Trp Ile Asn Gln Ala Ser 
        915                 920                 925             


Asp Glu Ser Gln Arg Met Val Leu Xaa Val Leu Pro Ser Glu Pro Xaa 
    930                 935                 940                 


Leu Pro Ser Arg Ile Cys Ser Ser Ala Pro Leu Leu Tyr Phe Leu Phe 
945                 950                 955                 960 


Ile Cys Pro Phe Val Leu Leu Leu Leu Leu Leu Ile Ser Leu Leu Cys 
                965                 970                 975     


Leu Tyr Trp Lys Ala Arg Lys Leu Ser Xaa Leu Arg Ser Asn Xaa Arg 
            980                 985                 990         


Lys Glu Lys Ala Leu Trp Val Asp  Leu Lys Glu Ala Gly  Gly Val Xaa 
        995                 1000                 1005             


Xaa Asn  Arg Arg Glu Asp Glu  Glu Glu Asp Glu Gly  Asn 
    1010                 1015                 1020     


<210> 5350
<211> 1368
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1107)..(1108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1123)..(1123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1131)..(1131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1226)..(1226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1280)..(1280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1297)..(1297)
<223> Selenocysteine

<400> 5350
Met Gln Gly Pro Pro Leu Leu Xaa Ala Ala His Leu Leu Cys Val Cys 
1               5                   10                  15      


Xaa Ala Ala Leu Ala Val Ala Pro Gly Pro Arg Phe Leu Val Xaa Ala 
            20                  25                  30          


Pro Gly Ile Ile Arg Pro Gly Gly Asn Val Xaa Ile Gly Val Glu Leu 
        35                  40                  45              


Leu Glu His Cys Pro Ser Gln Val Xaa Val Lys Ala Glu Leu Leu Lys 
    50                  55                  60                  


Xaa Ala Ser Asn Leu Xaa Val Ser Val Leu Glu Ala Glu Gly Val Phe 
65                  70                  75                  80  


Glu Lys Gly Ser Phe Lys Xaa Leu Xaa Leu Pro Ser Asp Pro Lys Ser 
                85                  90                  95      


Asn Leu Ile Gln Gln Trp Leu Ser Gln Gln Ser Asp Leu Gly Val Ile 
            100                 105                 110         


Ser Lys Xaa Phe Gln Leu Ser Ser His Pro Ile Leu Gly Asp Trp Ser 
        115                 120                 125             


Ile Gln Val Gln Val Asn Asp Gln Xaa Tyr Tyr Gln Ser Phe Gln Val 
    130                 135                 140                 


Ser Glu Tyr Val Leu Pro Lys Phe Glu Val Xaa Leu Gln Xaa Pro Leu 
145                 150                 155                 160 


Tyr Cys Ser Met Asn Ser Lys His Leu Asn Gly Xaa Ile Xaa Ala Lys 
                165                 170                 175     


Tyr Xaa Tyr Gly Lys Pro Val Lys Gly Asp Val Xaa Leu Xaa Phe Leu 
            180                 185                 190         


Pro Leu Ser Phe Trp Gly Lys Lys Lys Asn Ile Xaa Lys Xaa Phe Lys 
        195                 200                 205             


Ile Asn Gly Ser Ala Asn Phe Ser Phe Asn Asp Glu Glu Met Lys Asn 
    210                 215                 220                 


Val Met Asp Ser Ser Asn Gly Leu Ser Glu Tyr Leu Asp Leu Ser Ser 
225                 230                 235                 240 


Pro Gly Pro Val Glu Ile Leu Xaa Xaa Val Xaa Glu Ser Val Xaa Gly 
                245                 250                 255     


Ile Ser Arg Asn Val Ser Xaa Asn Val Phe Phe Lys Gln His Asp Tyr 
            260                 265                 270         


Ile Ile Glu Phe Phe Asp Tyr Xaa Xaa Val Leu Lys Pro Ser Leu Asn 
        275                 280                 285             


Phe Xaa Ala Xaa Val Lys Val Xaa Arg Ala Asp Gly Asn Gln Leu Xaa 
    290                 295                 300                 


Leu Glu Glu Arg Arg Asn Asn Val Val Ile Xaa Val Xaa Gln Arg Asn 
305                 310                 315                 320 


Tyr Xaa Glu Tyr Trp Ser Gly Ser Asn Ser Gly Asn Gln Lys Met Glu 
                325                 330                 335     


Ala Val Gln Lys Ile Asn Tyr Xaa Val Pro Gln Ser Gly Xaa Phe Lys 
            340                 345                 350         


Ile Glu Phe Pro Ile Leu Glu Asp Ser Ser Glu Leu Gln Leu Lys Ala 
        355                 360                 365             


Tyr Phe Leu Gly Ser Lys Ser Ser Met Ala Val His Ser Leu Phe Lys 
    370                 375                 380                 


Ser Pro Ser Lys Xaa Tyr Ile Gln Leu Lys Xaa Arg Asp Glu Asn Ile 
385                 390                 395                 400 


Lys Val Gly Ser Pro Phe Glu Leu Val Val Ser Gly Asn Lys Arg Leu 
                405                 410                 415     


Lys Glu Leu Ser Tyr Met Val Val Ser Arg Gly Gln Leu Val Ala Val 
            420                 425                 430         


Gly Lys Gln Asn Ser Xaa Met Phe Ser Leu Xaa Pro Glu Asn Ser Trp 
        435                 440                 445             


Xaa Pro Lys Ala Cys Val Ile Val Tyr Tyr Ile Glu Asp Asp Gly Glu 
    450                 455                 460                 


Ile Ile Ser Asp Val Leu Lys Ile Pro Val Gln Leu Val Phe Lys Asn 
465                 470                 475                 480 


Lys Ile Lys Leu Tyr Trp Ser Lys Val Lys Ala Glu Pro Ser Glu Lys 
                485                 490                 495     


Val Ser Leu Arg Ile Ser Val Xaa Gln Pro Asp Ser Ile Val Gly Ile 
            500                 505                 510         


Val Ala Val Asp Lys Ser Val Asn Leu Met Asn Ala Ser Asn Asp Ile 
        515                 520                 525             


Xaa Met Glu Asn Val Val His Glu Leu Glu Leu Tyr Asn Xaa Gly Tyr 
    530                 535                 540                 


Tyr Leu Gly Met Phe Met Asn Ser Phe Ala Val Phe Gln Glu Cys Gly 
545                 550                 555                 560 


Leu Trp Val Leu Xaa Asp Ala Asn Leu Xaa Lys Asp Tyr Ile Asp Gly 
                565                 570                 575     


Val Tyr Asp Asn Ala Glu Tyr Ala Glu Arg Phe Met Glu Glu Asn Glu 
            580                 585                 590         


Gly His Ile Val Asp Ile His Asp Phe Ser Leu Gly Ser Ser Pro His 
        595                 600                 605             


Val Arg Lys His Phe Pro Glu Xaa Trp Ile Trp Leu Asp Xaa Asn Met 
    610                 615                 620                 


Gly Tyr Arg Ile Tyr Gln Glu Phe Glu Val Xaa Val Pro Asp Ser Ile 
625                 630                 635                 640 


Xaa Ser Trp Val Ala Xaa Gly Phe Val Ile Ser Glu Asp Leu Gly Leu 
                645                 650                 655     


Gly Leu Xaa Xaa Xaa Pro Val Glu Leu Gln Ala Phe Gln Pro Phe Phe 
            660                 665                 670         


Ile Phe Leu Asn Leu Pro Tyr Ser Val Ile Arg Gly Glu Glu Phe Ala 
        675                 680                 685             


Leu Glu Ile Xaa Ile Phe Asn Tyr Leu Lys Asp Ala Xaa Glu Val Lys 
    690                 695                 700                 


Val Ile Ile Glu Lys Ser Asp Lys Phe Asp Ile Leu Met Xaa Ser Asn 
705                 710                 715                 720 


Glu Ile Asn Ala Xaa Gly His Gln Gln Xaa Leu Leu Val Pro Ser Glu 
                725                 730                 735     


Asp Gly Ala Xaa Val Leu Phe Pro Ile Arg Pro Xaa His Leu Gly Glu 
            740                 745                 750         


Ile Pro Ile Xaa Val Xaa Ala Leu Ser Pro Xaa Ala Ser Asp Ala Val 
        755                 760                 765             


Xaa Gln Met Ile Leu Val Lys Ala Glu Gly Ile Glu Lys Ser Tyr Ser 
    770                 775                 780                 


Gln Ser Ile Leu Leu Asp Leu Xaa Asp Asn Arg Leu Gln Ser Xaa Leu 
785                 790                 795                 800 


Lys Xaa Leu Ser Phe Ser Phe Pro Pro Asn Xaa Val Xaa Gly Ser Glu 
                805                 810                 815     


Arg Val Gln Ile Xaa Ala Ile Gly Asp Val Leu Gly Pro Ser Ile Asn 
            820                 825                 830         


Gly Leu Ala Ser Leu Ile Arg Met Pro Tyr Gly Cys Gly Glu Gln Asn 
        835                 840                 845             


Met Ile Asn Phe Ala Pro Asn Ile Tyr Ile Leu Asp Tyr Leu Xaa Lys 
    850                 855                 860                 


Lys Lys Gln Leu Xaa Asp Asn Leu Lys Glu Lys Ala Leu Ser Phe Met 
865                 870                 875                 880 


Arg Gln Gly Tyr Gln Arg Glu Leu Leu Tyr Gln Arg Glu Asp Gly Ser 
                885                 890                 895     


Phe Ser Ala Phe Gly Asn Tyr Asp Pro Ser Gly Ser Xaa Trp Leu Ser 
            900                 905                 910         


Ala Phe Val Leu Arg Cys Phe Leu Glu Ala Asp Pro Tyr Ile Asp Ile 
        915                 920                 925             


Asp Gln Asn Val Leu His Arg Xaa Tyr Xaa Trp Leu Lys Gly His Gln 
    930                 935                 940                 


Lys Ser Asn Gly Glu Phe Trp Asp Pro Gly Arg Val Ile His Ser Glu 
945                 950                 955                 960 


Leu Gln Gly Gly Asn Lys Ser Pro Val Xaa Leu Xaa Ala Tyr Ile Val 
                965                 970                 975     


Xaa Ser Leu Leu Gly Tyr Arg Lys Tyr Gln Pro Asn Ile Asp Val Gln 
            980                 985                 990         


Glu Ser Ile His Phe Leu Glu Ser  Glu Phe Ser Arg Gly  Ile Ser Asp 
        995                 1000                 1005             


Asn Tyr  Xaa Leu Ala Leu Ile  Xaa Tyr Ala Leu Ser  Ser Val Gly 
    1010                 1015                 1020             


Ser Pro  Lys Ala Lys Glu Ala  Leu Asn Met Leu Xaa  Trp Arg Ala 
    1025                 1030                 1035             


Glu Gln  Glu Gly Gly Met Gln  Phe Trp Val Ser Ser  Glu Ser Lys 
    1040                 1045                 1050             


Leu Ser  Asp Ser Trp Gln Pro  Arg Ser Leu Asp Ile  Glu Val Ala 
    1055                 1060                 1065             


Ala Tyr  Ala Leu Leu Ser His  Phe Leu Gln Phe Gln  Xaa Ser Glu 
    1070                 1075                 1080             


Gly Ile  Pro Ile Met Arg Trp  Leu Ser Arg Gln Arg  Asn Ser Leu 
    1085                 1090                 1095             


Gly Gly  Phe Ala Ser Xaa Gln  Asp Xaa Xaa Val Ala  Leu Lys Ala 
    1100                 1105                 1110             


Leu Ser  Glu Phe Ala Ala Leu  Met Asn Xaa Glu Arg  Xaa Asn Ile 
    1115                 1120                 1125             


Gln Val  Xaa Val Xaa Gly Pro  Ser Ser Pro Ser Pro  Val Lys Phe 
    1130                 1135                 1140             


Leu Ile  Asp Xaa His Asn Arg  Leu Leu Leu Gln Xaa  Ala Glu Leu 
    1145                 1150                 1155             


Ala Val  Val Gln Pro Xaa Ala  Val Asn Ile Ser Ala  Asn Gly Phe 
    1160                 1165                 1170             


Gly Phe  Ala Ile Cys Gln Leu  Asn Val Val Tyr Asn  Val Lys Ala 
    1175                 1180                 1185             


Ser Gly  Ser Ser Arg Arg Arg  Arg Ser Ile Gln Asn  Gln Glu Ala 
    1190                 1195                 1200             


Phe Asp  Leu Asp Val Ala Val  Lys Glu Asn Lys Asp  Asp Leu Asn 
    1205                 1210                 1215             


His Val  Asp Leu Asn Val Cys  Xaa Ser Phe Ser Gly  Pro Gly Arg 
    1220                 1225                 1230             


Ser Gly  Met Ala Leu Met Glu  Val Asn Leu Leu Ser  Gly Phe Met 
    1235                 1240                 1245             


Val Pro  Ser Glu Ala Ile Ser  Leu Ser Glu Xaa Val  Lys Lys Val 
    1250                 1255                 1260             


Glu Tyr  Asp His Gly Lys Leu  Asn Leu Tyr Leu Asp  Ser Val Asn 
    1265                 1270                 1275             


Glu Xaa  Gln Phe Cys Val Asn  Ile Pro Ala Val Arg  Asn Phe Lys 
    1280                 1285                 1290             


Val Ser  Asn Xaa Gln Asp Ala  Ser Val Ser Ile Val  Asp Tyr Tyr 
    1295                 1300                 1305             


Glu Pro  Arg Arg Gln Ala Val  Arg Ser Tyr Asn Ser  Glu Val Lys 
    1310                 1315                 1320             


Leu Ser  Ser Cys Asp Leu Cys  Ser Asp Val Gln Gly  Cys Arg Pro 
    1325                 1330                 1335             


Cys Glu  Asp Gly Ala Ser Gly  Ser His His His Ser  Ser Val Ile 
    1340                 1345                 1350             


Phe Ile  Phe Cys Phe Lys Leu  Leu Tyr Phe Met Glu  Leu Trp Leu 
    1355                 1360                 1365             


<210> 5351
<211> 1428
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1093)..(1093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1184)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1200)..(1200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1208)..(1208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1224)..(1224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1319)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1340)..(1340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1357)..(1357)
<223> Selenocysteine

<400> 5351
Met Gln Gly Pro Pro Leu Leu Xaa Ala Ala His Leu Leu Cys Val Cys 
1               5                   10                  15      


Xaa Ala Ala Leu Ala Val Ala Pro Gly Pro Arg Phe Leu Val Xaa Ala 
            20                  25                  30          


Pro Gly Ile Ile Arg Pro Gly Gly Asn Val Xaa Ile Gly Val Glu Leu 
        35                  40                  45              


Leu Glu His Cys Pro Ser Gln Val Xaa Val Lys Ala Glu Leu Leu Lys 
    50                  55                  60                  


Xaa Ala Ser Asn Leu Xaa Val Ser Val Leu Glu Ala Glu Gly Val Phe 
65                  70                  75                  80  


Glu Lys Gly Ser Phe Lys Xaa Leu Xaa Leu Pro Ser Leu Pro Leu Asn 
                85                  90                  95      


Ser Ala Asp Glu Ile Tyr Glu Leu Arg Val Xaa Gly Arg Xaa Gln Asp 
            100                 105                 110         


Glu Ile Leu Phe Ser Asn Ser Xaa Arg Leu Ser Phe Glu Xaa Lys Arg 
        115                 120                 125             


Ile Ser Val Phe Ile Gln Xaa Asp Lys Ala Leu Tyr Lys Pro Lys Gln 
    130                 135                 140                 


Glu Val Lys Phe Arg Ile Val Xaa Leu Phe Ser Asp Phe Lys Pro Tyr 
145                 150                 155                 160 


Lys Xaa Ser Leu Asn Ile Leu Ile Lys Asp Pro Lys Ser Asn Leu Ile 
                165                 170                 175     


Gln Gln Trp Leu Ser Gln Gln Ser Asp Leu Gly Val Ile Ser Lys Xaa 
            180                 185                 190         


Phe Gln Leu Ser Ser His Pro Ile Leu Gly Asp Trp Ser Ile Gln Val 
        195                 200                 205             


Gln Val Asn Asp Gln Xaa Tyr Tyr Gln Ser Phe Gln Val Ser Glu Tyr 
    210                 215                 220                 


Val Leu Pro Lys Phe Glu Val Xaa Leu Gln Xaa Pro Leu Tyr Cys Ser 
225                 230                 235                 240 


Met Asn Ser Lys His Leu Asn Gly Xaa Ile Xaa Ala Lys Tyr Xaa Tyr 
                245                 250                 255     


Gly Lys Pro Val Lys Gly Asp Val Xaa Leu Xaa Phe Leu Pro Leu Ser 
            260                 265                 270         


Phe Trp Gly Lys Lys Lys Asn Ile Xaa Lys Xaa Phe Lys Ile Asn Gly 
        275                 280                 285             


Ser Ala Asn Phe Ser Phe Asn Asp Glu Glu Met Lys Asn Val Met Asp 
    290                 295                 300                 


Ser Ser Asn Gly Leu Ser Glu Tyr Leu Asp Leu Ser Ser Pro Gly Pro 
305                 310                 315                 320 


Val Glu Ile Leu Xaa Xaa Val Xaa Glu Ser Val Xaa Gly Ile Ser Arg 
                325                 330                 335     


Asn Val Ser Xaa Asn Val Phe Phe Lys Gln His Asp Tyr Ile Ile Glu 
            340                 345                 350         


Phe Phe Asp Tyr Xaa Xaa Val Leu Lys Pro Ser Leu Asn Phe Xaa Ala 
        355                 360                 365             


Xaa Val Lys Val Xaa Arg Ala Asp Gly Asn Gln Leu Xaa Leu Glu Glu 
    370                 375                 380                 


Arg Arg Asn Asn Val Val Ile Xaa Val Xaa Gln Arg Asn Tyr Xaa Glu 
385                 390                 395                 400 


Tyr Trp Ser Gly Ser Asn Ser Gly Asn Gln Lys Met Glu Ala Val Gln 
                405                 410                 415     


Lys Ile Asn Tyr Xaa Val Pro Gln Ser Gly Xaa Phe Lys Ile Glu Phe 
            420                 425                 430         


Pro Ile Leu Glu Asp Ser Ser Glu Leu Gln Leu Lys Ala Tyr Phe Leu 
        435                 440                 445             


Gly Ser Lys Ser Ser Met Ala Val His Ser Leu Phe Lys Ser Pro Ser 
    450                 455                 460                 


Lys Xaa Tyr Ile Gln Leu Lys Xaa Arg Asp Glu Asn Ile Lys Val Gly 
465                 470                 475                 480 


Ser Pro Phe Glu Leu Val Val Ser Gly Asn Lys Arg Leu Lys Glu Leu 
                485                 490                 495     


Ser Tyr Met Val Val Ser Arg Gly Gln Leu Val Ala Val Gly Lys Gln 
            500                 505                 510         


Asn Ser Xaa Met Phe Ser Leu Xaa Pro Glu Asn Ser Trp Xaa Pro Lys 
        515                 520                 525             


Ala Cys Val Ile Val Tyr Tyr Ile Glu Asp Asp Gly Glu Ile Ile Ser 
    530                 535                 540                 


Asp Val Leu Lys Ile Pro Val Gln Leu Val Phe Lys Asn Lys Ile Lys 
545                 550                 555                 560 


Leu Tyr Trp Ser Lys Val Lys Ala Glu Pro Ser Glu Lys Val Ser Leu 
                565                 570                 575     


Arg Ile Ser Val Xaa Gln Pro Asp Ser Ile Val Gly Ile Val Ala Val 
            580                 585                 590         


Asp Lys Ser Val Asn Leu Met Asn Ala Ser Asn Asp Ile Xaa Met Glu 
        595                 600                 605             


Asn Val Val His Glu Leu Glu Leu Tyr Asn Xaa Gly Tyr Tyr Leu Gly 
    610                 615                 620                 


Met Phe Met Asn Ser Phe Ala Val Phe Gln Glu Cys Gly Leu Trp Val 
625                 630                 635                 640 


Leu Xaa Asp Ala Asn Leu Xaa Lys Asp Tyr Ile Asp Gly Val Tyr Asp 
                645                 650                 655     


Asn Ala Glu Tyr Ala Glu Arg Phe Met Glu Glu Asn Glu Gly His Ile 
            660                 665                 670         


Val Asp Ile His Asp Phe Ser Leu Gly Ser Ser Pro His Val Arg Lys 
        675                 680                 685             


His Phe Pro Glu Xaa Trp Ile Trp Leu Asp Xaa Asn Met Gly Tyr Arg 
    690                 695                 700                 


Ile Tyr Gln Glu Phe Glu Val Xaa Val Pro Asp Ser Ile Xaa Ser Trp 
705                 710                 715                 720 


Val Ala Xaa Gly Phe Val Ile Ser Glu Asp Leu Gly Leu Gly Leu Xaa 
                725                 730                 735     


Xaa Xaa Pro Val Glu Leu Gln Ala Phe Gln Pro Phe Phe Ile Phe Leu 
            740                 745                 750         


Asn Leu Pro Tyr Ser Val Ile Arg Gly Glu Glu Phe Ala Leu Glu Ile 
        755                 760                 765             


Xaa Ile Phe Asn Tyr Leu Lys Asp Ala Xaa Glu Val Lys Val Ile Ile 
    770                 775                 780                 


Glu Lys Ser Asp Lys Phe Asp Ile Leu Met Xaa Ser Asn Glu Ile Asn 
785                 790                 795                 800 


Ala Xaa Gly His Gln Gln Xaa Leu Leu Val Pro Ser Glu Asp Gly Ala 
                805                 810                 815     


Xaa Val Leu Phe Pro Ile Arg Pro Xaa His Leu Gly Glu Ile Pro Ile 
            820                 825                 830         


Xaa Val Xaa Ala Leu Ser Pro Xaa Ala Ser Asp Ala Val Xaa Gln Met 
        835                 840                 845             


Ile Leu Val Lys Ala Glu Gly Ile Glu Lys Ser Tyr Ser Gln Ser Ile 
    850                 855                 860                 


Leu Leu Asp Leu Xaa Asp Asn Arg Leu Gln Ser Xaa Leu Lys Xaa Leu 
865                 870                 875                 880 


Ser Phe Ser Phe Pro Pro Asn Xaa Val Xaa Gly Ser Glu Arg Val Gln 
                885                 890                 895     


Ile Xaa Ala Ile Gly Asp Val Leu Gly Pro Ser Ile Asn Gly Leu Ala 
            900                 905                 910         


Ser Leu Ile Arg Met Pro Tyr Gly Cys Gly Glu Gln Asn Met Ile Asn 
        915                 920                 925             


Phe Ala Pro Asn Ile Tyr Ile Leu Asp Tyr Leu Xaa Lys Lys Lys Gln 
    930                 935                 940                 


Leu Xaa Asp Asn Leu Lys Glu Lys Ala Leu Ser Phe Met Arg Gln Gly 
945                 950                 955                 960 


Tyr Gln Arg Glu Leu Leu Tyr Gln Arg Glu Asp Gly Ser Phe Ser Ala 
                965                 970                 975     


Phe Gly Asn Tyr Asp Pro Ser Gly Ser Xaa Trp Leu Ser Ala Phe Val 
            980                 985                 990         


Leu Arg Cys Phe Leu Glu Ala Asp  Pro Tyr Ile Asp Ile  Asp Gln Asn 
        995                 1000                 1005             


Val Leu  His Arg Xaa Tyr Xaa  Trp Leu Lys Gly His  Gln Lys Ser 
    1010                 1015                 1020             


Asn Gly  Glu Phe Trp Asp Pro  Gly Arg Val Ile His  Ser Glu Leu 
    1025                 1030                 1035             


Gln Gly  Gly Asn Lys Ser Pro  Val Xaa Leu Xaa Ala  Tyr Ile Val 
    1040                 1045                 1050             


Xaa Ser  Leu Leu Gly Tyr Arg  Lys Tyr Gln Pro Asn  Ile Asp Val 
    1055                 1060                 1065             


Gln Glu  Ser Ile His Phe Leu  Glu Ser Glu Phe Ser  Arg Gly Ile 
    1070                 1075                 1080             


Ser Asp  Asn Tyr Xaa Leu Ala  Leu Ile Xaa Tyr Ala  Leu Ser Ser 
    1085                 1090                 1095             


Val Gly  Ser Pro Lys Ala Lys  Glu Ala Leu Asn Met  Leu Xaa Trp 
    1100                 1105                 1110             


Arg Ala  Glu Gln Glu Gly Gly  Met Gln Phe Trp Val  Ser Ser Glu 
    1115                 1120                 1125             


Ser Lys  Leu Ser Asp Ser Trp  Gln Pro Arg Ser Leu  Asp Ile Glu 
    1130                 1135                 1140             


Val Ala  Ala Tyr Ala Leu Leu  Ser His Phe Leu Gln  Phe Gln Xaa 
    1145                 1150                 1155             


Ser Glu  Gly Ile Pro Ile Met  Arg Trp Leu Ser Arg  Gln Arg Asn 
    1160                 1165                 1170             


Ser Leu  Gly Gly Phe Ala Ser  Xaa Gln Asp Xaa Xaa  Val Ala Leu 
    1175                 1180                 1185             


Lys Ala  Leu Ser Glu Phe Ala  Ala Leu Met Asn Xaa  Glu Arg Xaa 
    1190                 1195                 1200             


Asn Ile  Gln Val Xaa Val Xaa  Gly Pro Ser Ser Pro  Ser Pro Leu 
    1205                 1210                 1215             


Ala Val  Val Gln Pro Xaa Ala  Val Asn Ile Ser Ala  Asn Gly Phe 
    1220                 1225                 1230             


Gly Phe  Ala Ile Cys Gln Leu  Asn Val Val Tyr Asn  Val Lys Ala 
    1235                 1240                 1245             


Ser Gly  Ser Ser Arg Arg Arg  Arg Ser Ile Gln Asn  Gln Glu Ala 
    1250                 1255                 1260             


Phe Asp  Leu Asp Val Ala Val  Lys Glu Asn Lys Asp  Asp Leu Asn 
    1265                 1270                 1275             


His Val  Asp Leu Asn Val Cys  Xaa Ser Phe Ser Gly  Pro Gly Arg 
    1280                 1285                 1290             


Ser Gly  Met Ala Leu Met Glu  Val Asn Leu Leu Ser  Gly Phe Met 
    1295                 1300                 1305             


Val Pro  Ser Glu Ala Ile Ser  Leu Ser Glu Xaa Val  Lys Lys Val 
    1310                 1315                 1320             


Glu Tyr  Asp His Gly Lys Leu  Asn Leu Tyr Leu Asp  Ser Val Asn 
    1325                 1330                 1335             


Glu Xaa  Gln Phe Cys Val Asn  Ile Pro Ala Val Arg  Asn Phe Lys 
    1340                 1345                 1350             


Val Ser  Asn Xaa Gln Asp Ala  Ser Val Ser Ile Val  Asp Tyr Tyr 
    1355                 1360                 1365             


Glu Pro  Arg Arg Gln Ala Val  Arg Ser Tyr Asn Ser  Glu Val Lys 
    1370                 1375                 1380             


Leu Ser  Ser Cys Asp Leu Cys  Ser Asp Val Gln Gly  Cys Arg Pro 
    1385                 1390                 1395             


Cys Glu  Asp Gly Ala Ser Gly  Ser His His His Ser  Ser Val Ile 
    1400                 1405                 1410             


Phe Ile  Phe Cys Phe Lys Leu  Leu Tyr Phe Met Glu  Leu Trp Leu 
    1415                 1420                 1425             


<210> 5352
<211> 1445
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1093)..(1093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1184)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1200)..(1200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1208)..(1208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1224)..(1224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1357)..(1357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1374)..(1374)
<223> Selenocysteine

<400> 5352
Met Gln Gly Pro Pro Leu Leu Xaa Ala Ala His Leu Leu Cys Val Cys 
1               5                   10                  15      


Xaa Ala Ala Leu Ala Val Ala Pro Gly Pro Arg Phe Leu Val Xaa Ala 
            20                  25                  30          


Pro Gly Ile Ile Arg Pro Gly Gly Asn Val Xaa Ile Gly Val Glu Leu 
        35                  40                  45              


Leu Glu His Cys Pro Ser Gln Val Xaa Val Lys Ala Glu Leu Leu Lys 
    50                  55                  60                  


Xaa Ala Ser Asn Leu Xaa Val Ser Val Leu Glu Ala Glu Gly Val Phe 
65                  70                  75                  80  


Glu Lys Gly Ser Phe Lys Xaa Leu Xaa Leu Pro Ser Leu Pro Leu Asn 
                85                  90                  95      


Ser Ala Asp Glu Ile Tyr Glu Leu Arg Val Xaa Gly Arg Xaa Gln Asp 
            100                 105                 110         


Glu Ile Leu Phe Ser Asn Ser Xaa Arg Leu Ser Phe Glu Xaa Lys Arg 
        115                 120                 125             


Ile Ser Val Phe Ile Gln Xaa Asp Lys Ala Leu Tyr Lys Pro Lys Gln 
    130                 135                 140                 


Glu Val Lys Phe Arg Ile Val Xaa Leu Phe Ser Asp Phe Lys Pro Tyr 
145                 150                 155                 160 


Lys Xaa Ser Leu Asn Ile Leu Ile Lys Asp Pro Lys Ser Asn Leu Ile 
                165                 170                 175     


Gln Gln Trp Leu Ser Gln Gln Ser Asp Leu Gly Val Ile Ser Lys Xaa 
            180                 185                 190         


Phe Gln Leu Ser Ser His Pro Ile Leu Gly Asp Trp Ser Ile Gln Val 
        195                 200                 205             


Gln Val Asn Asp Gln Xaa Tyr Tyr Gln Ser Phe Gln Val Ser Glu Tyr 
    210                 215                 220                 


Val Leu Pro Lys Phe Glu Val Xaa Leu Gln Xaa Pro Leu Tyr Cys Ser 
225                 230                 235                 240 


Met Asn Ser Lys His Leu Asn Gly Xaa Ile Xaa Ala Lys Tyr Xaa Tyr 
                245                 250                 255     


Gly Lys Pro Val Lys Gly Asp Val Xaa Leu Xaa Phe Leu Pro Leu Ser 
            260                 265                 270         


Phe Trp Gly Lys Lys Lys Asn Ile Xaa Lys Xaa Phe Lys Ile Asn Gly 
        275                 280                 285             


Ser Ala Asn Phe Ser Phe Asn Asp Glu Glu Met Lys Asn Val Met Asp 
    290                 295                 300                 


Ser Ser Asn Gly Leu Ser Glu Tyr Leu Asp Leu Ser Ser Pro Gly Pro 
305                 310                 315                 320 


Val Glu Ile Leu Xaa Xaa Val Xaa Glu Ser Val Xaa Gly Ile Ser Arg 
                325                 330                 335     


Asn Val Ser Xaa Asn Val Phe Phe Lys Gln His Asp Tyr Ile Ile Glu 
            340                 345                 350         


Phe Phe Asp Tyr Xaa Xaa Val Leu Lys Pro Ser Leu Asn Phe Xaa Ala 
        355                 360                 365             


Xaa Val Lys Val Xaa Arg Ala Asp Gly Asn Gln Leu Xaa Leu Glu Glu 
    370                 375                 380                 


Arg Arg Asn Asn Val Val Ile Xaa Val Xaa Gln Arg Asn Tyr Xaa Glu 
385                 390                 395                 400 


Tyr Trp Ser Gly Ser Asn Ser Gly Asn Gln Lys Met Glu Ala Val Gln 
                405                 410                 415     


Lys Ile Asn Tyr Xaa Val Pro Gln Ser Gly Xaa Phe Lys Ile Glu Phe 
            420                 425                 430         


Pro Ile Leu Glu Asp Ser Ser Glu Leu Gln Leu Lys Ala Tyr Phe Leu 
        435                 440                 445             


Gly Ser Lys Ser Ser Met Ala Val His Ser Leu Phe Lys Ser Pro Ser 
    450                 455                 460                 


Lys Xaa Tyr Ile Gln Leu Lys Xaa Arg Asp Glu Asn Ile Lys Val Gly 
465                 470                 475                 480 


Ser Pro Phe Glu Leu Val Val Ser Gly Asn Lys Arg Leu Lys Glu Leu 
                485                 490                 495     


Ser Tyr Met Val Val Ser Arg Gly Gln Leu Val Ala Val Gly Lys Gln 
            500                 505                 510         


Asn Ser Xaa Met Phe Ser Leu Xaa Pro Glu Asn Ser Trp Xaa Pro Lys 
        515                 520                 525             


Ala Cys Val Ile Val Tyr Tyr Ile Glu Asp Asp Gly Glu Ile Ile Ser 
    530                 535                 540                 


Asp Val Leu Lys Ile Pro Val Gln Leu Val Phe Lys Asn Lys Ile Lys 
545                 550                 555                 560 


Leu Tyr Trp Ser Lys Val Lys Ala Glu Pro Ser Glu Lys Val Ser Leu 
                565                 570                 575     


Arg Ile Ser Val Xaa Gln Pro Asp Ser Ile Val Gly Ile Val Ala Val 
            580                 585                 590         


Asp Lys Ser Val Asn Leu Met Asn Ala Ser Asn Asp Ile Xaa Met Glu 
        595                 600                 605             


Asn Val Val His Glu Leu Glu Leu Tyr Asn Xaa Gly Tyr Tyr Leu Gly 
    610                 615                 620                 


Met Phe Met Asn Ser Phe Ala Val Phe Gln Glu Cys Gly Leu Trp Val 
625                 630                 635                 640 


Leu Xaa Asp Ala Asn Leu Xaa Lys Asp Tyr Ile Asp Gly Val Tyr Asp 
                645                 650                 655     


Asn Ala Glu Tyr Ala Glu Arg Phe Met Glu Glu Asn Glu Gly His Ile 
            660                 665                 670         


Val Asp Ile His Asp Phe Ser Leu Gly Ser Ser Pro His Val Arg Lys 
        675                 680                 685             


His Phe Pro Glu Xaa Trp Ile Trp Leu Asp Xaa Asn Met Gly Tyr Arg 
    690                 695                 700                 


Ile Tyr Gln Glu Phe Glu Val Xaa Val Pro Asp Ser Ile Xaa Ser Trp 
705                 710                 715                 720 


Val Ala Xaa Gly Phe Val Ile Ser Glu Asp Leu Gly Leu Gly Leu Xaa 
                725                 730                 735     


Xaa Xaa Pro Val Glu Leu Gln Ala Phe Gln Pro Phe Phe Ile Phe Leu 
            740                 745                 750         


Asn Leu Pro Tyr Ser Val Ile Arg Gly Glu Glu Phe Ala Leu Glu Ile 
        755                 760                 765             


Xaa Ile Phe Asn Tyr Leu Lys Asp Ala Xaa Glu Val Lys Val Ile Ile 
    770                 775                 780                 


Glu Lys Ser Asp Lys Phe Asp Ile Leu Met Xaa Ser Asn Glu Ile Asn 
785                 790                 795                 800 


Ala Xaa Gly His Gln Gln Xaa Leu Leu Val Pro Ser Glu Asp Gly Ala 
                805                 810                 815     


Xaa Val Leu Phe Pro Ile Arg Pro Xaa His Leu Gly Glu Ile Pro Ile 
            820                 825                 830         


Xaa Val Xaa Ala Leu Ser Pro Xaa Ala Ser Asp Ala Val Xaa Gln Met 
        835                 840                 845             


Ile Leu Val Lys Ala Glu Gly Ile Glu Lys Ser Tyr Ser Gln Ser Ile 
    850                 855                 860                 


Leu Leu Asp Leu Xaa Asp Asn Arg Leu Gln Ser Xaa Leu Lys Xaa Leu 
865                 870                 875                 880 


Ser Phe Ser Phe Pro Pro Asn Xaa Val Xaa Gly Ser Glu Arg Val Gln 
                885                 890                 895     


Ile Xaa Ala Ile Gly Asp Val Leu Gly Pro Ser Ile Asn Gly Leu Ala 
            900                 905                 910         


Ser Leu Ile Arg Met Pro Tyr Gly Cys Gly Glu Gln Asn Met Ile Asn 
        915                 920                 925             


Phe Ala Pro Asn Ile Tyr Ile Leu Asp Tyr Leu Xaa Lys Lys Lys Gln 
    930                 935                 940                 


Leu Xaa Asp Asn Leu Lys Glu Lys Ala Leu Ser Phe Met Arg Gln Gly 
945                 950                 955                 960 


Tyr Gln Arg Glu Leu Leu Tyr Gln Arg Glu Asp Gly Ser Phe Ser Ala 
                965                 970                 975     


Phe Gly Asn Tyr Asp Pro Ser Gly Ser Xaa Trp Leu Ser Ala Phe Val 
            980                 985                 990         


Leu Arg Cys Phe Leu Glu Ala Asp  Pro Tyr Ile Asp Ile  Asp Gln Asn 
        995                 1000                 1005             


Val Leu  His Arg Xaa Tyr Xaa  Trp Leu Lys Gly His  Gln Lys Ser 
    1010                 1015                 1020             


Asn Gly  Glu Phe Trp Asp Pro  Gly Arg Val Ile His  Ser Glu Leu 
    1025                 1030                 1035             


Gln Gly  Gly Asn Lys Ser Pro  Val Xaa Leu Xaa Ala  Tyr Ile Val 
    1040                 1045                 1050             


Xaa Ser  Leu Leu Gly Tyr Arg  Lys Tyr Gln Pro Asn  Ile Asp Val 
    1055                 1060                 1065             


Gln Glu  Ser Ile His Phe Leu  Glu Ser Glu Phe Ser  Arg Gly Ile 
    1070                 1075                 1080             


Ser Asp  Asn Tyr Xaa Leu Ala  Leu Ile Xaa Tyr Ala  Leu Ser Ser 
    1085                 1090                 1095             


Val Gly  Ser Pro Lys Ala Lys  Glu Ala Leu Asn Met  Leu Xaa Trp 
    1100                 1105                 1110             


Arg Ala  Glu Gln Glu Gly Gly  Met Gln Phe Trp Val  Ser Ser Glu 
    1115                 1120                 1125             


Ser Lys  Leu Ser Asp Ser Trp  Gln Pro Arg Ser Leu  Asp Ile Glu 
    1130                 1135                 1140             


Val Ala  Ala Tyr Ala Leu Leu  Ser His Phe Leu Gln  Phe Gln Xaa 
    1145                 1150                 1155             


Ser Glu  Gly Ile Pro Ile Met  Arg Trp Leu Ser Arg  Gln Arg Asn 
    1160                 1165                 1170             


Ser Leu  Gly Gly Phe Ala Ser  Xaa Gln Asp Xaa Xaa  Val Ala Leu 
    1175                 1180                 1185             


Lys Ala  Leu Ser Glu Phe Ala  Ala Leu Met Asn Xaa  Glu Arg Xaa 
    1190                 1195                 1200             


Asn Ile  Gln Val Xaa Val Xaa  Gly Pro Ser Ser Pro  Ser Pro Val 
    1205                 1210                 1215             


Lys Phe  Leu Ile Asp Xaa His  Asn Arg Leu Leu Leu  Gln Xaa Ala 
    1220                 1225                 1230             


Glu Leu  Ala Val Val Gln Pro  Xaa Ala Val Asn Ile  Ser Ala Asn 
    1235                 1240                 1245             


Gly Phe  Gly Phe Ala Ile Cys  Gln Leu Asn Val Val  Tyr Asn Val 
    1250                 1255                 1260             


Lys Ala  Ser Gly Ser Ser Arg  Arg Arg Arg Ser Ile  Gln Asn Gln 
    1265                 1270                 1275             


Glu Ala  Phe Asp Leu Asp Val  Ala Val Lys Glu Asn  Lys Asp Asp 
    1280                 1285                 1290             


Leu Asn  His Val Asp Leu Asn  Val Cys Xaa Ser Phe  Ser Gly Pro 
    1295                 1300                 1305             


Gly Arg  Ser Gly Met Ala Leu  Met Glu Val Asn Leu  Leu Ser Gly 
    1310                 1315                 1320             


Phe Met  Val Pro Ser Glu Ala  Ile Ser Leu Ser Glu  Xaa Val Lys 
    1325                 1330                 1335             


Lys Val  Glu Tyr Asp His Gly  Lys Leu Asn Leu Tyr  Leu Asp Ser 
    1340                 1345                 1350             


Val Asn  Glu Xaa Gln Phe Cys  Val Asn Ile Pro Ala  Val Arg Asn 
    1355                 1360                 1365             


Phe Lys  Val Ser Asn Xaa Gln  Asp Ala Ser Val Ser  Ile Val Asp 
    1370                 1375                 1380             


Tyr Tyr  Glu Pro Arg Arg Gln  Ala Val Arg Ser Tyr  Asn Ser Glu 
    1385                 1390                 1395             


Val Lys  Leu Ser Ser Cys Asp  Leu Cys Ser Asp Val  Gln Gly Cys 
    1400                 1405                 1410             


Arg Pro  Cys Glu Asp Gly Ala  Ser Gly Ser His His  His Ser Ser 
    1415                 1420                 1425             


Val Ile  Phe Ile Phe Cys Phe  Lys Leu Leu Tyr Phe  Met Glu Leu 
    1430                 1435                 1440             


Trp Leu  
    1445 


<210> 5353
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<400> 5353
Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 
1               5                   10                  15      


Val Ser Ala Xaa Xaa Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 
            20                  25                  30          


Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 
        35                  40                  45              


Phe Gln Cys Val Ser Ala Val 
    50                  55  


<210> 5354
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<400> 5354
Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 
1               5                   10                  15      


Val Ser Ala Xaa Xaa Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 
            20                  25                  30          


Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 
        35                  40                  45              


Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu 
    50                  55                  60                  


Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg 
65                  70                  75                  80  


Gln 
    


<210> 5355
<211> 213
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<400> 5355
Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 
1               5                   10                  15      


Val Ser Ala Xaa Xaa Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 
            20                  25                  30          


Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 
        35                  40                  45              


Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu 
    50                  55                  60                  


Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg 
65                  70                  75                  80  


Gln Tyr Ala Asp Xaa Val Lys Ala Leu Arg Val Arg Arg Leu Xaa Val 
                85                  90                  95      


Gly Ala Ala Gln Val Pro Ala Gln Leu Leu Val Gly Ala Leu Arg Val 
            100                 105                 110         


Leu Ala Tyr Ser Arg Leu Lys Glu Leu Xaa Leu Glu Asp Leu Lys Ile 
        115                 120                 125             


Xaa Gly Xaa Met Pro Pro Leu Pro Leu Glu Ala Xaa Gly Leu Ala Leu 
    130                 135                 140                 


Ser Ser Leu Arg Leu Arg Asn Val Ser Trp Ala Xaa Gly Arg Ser Trp 
145                 150                 155                 160 


Leu Ala Glu Leu Gln Gln Trp Leu Lys Pro Gly Leu Lys Val Leu Ser 
                165                 170                 175     


Ile Ala Gln Ala His Ser Pro Ala Phe Ser Cys Glu Gln Val Arg Ala 
            180                 185                 190         


Phe Pro Ala Leu Xaa Ser Leu Asp Leu Ser Asp Asn Pro Gly Leu Gly 
        195                 200                 205             


Glu Arg Gly Leu Met 
    210             


<210> 5356
<211> 375
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<400> 5356
Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 
1               5                   10                  15      


Val Ser Ala Xaa Xaa Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 
            20                  25                  30          


Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 
        35                  40                  45              


Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu 
    50                  55                  60                  


Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg 
65                  70                  75                  80  


Gln Tyr Ala Asp Xaa Val Lys Ala Leu Arg Val Arg Arg Leu Xaa Val 
                85                  90                  95      


Gly Ala Ala Gln Val Pro Ala Gln Leu Leu Val Gly Ala Leu Arg Val 
            100                 105                 110         


Leu Ala Tyr Ser Arg Leu Lys Glu Leu Xaa Leu Glu Asp Leu Lys Ile 
        115                 120                 125             


Xaa Gly Xaa Met Pro Pro Leu Pro Leu Glu Ala Xaa Gly Leu Ala Leu 
    130                 135                 140                 


Ser Ser Leu Arg Leu Arg Asn Val Ser Trp Ala Xaa Gly Arg Ser Trp 
145                 150                 155                 160 


Leu Ala Glu Leu Gln Gln Trp Leu Lys Pro Gly Leu Lys Val Leu Ser 
                165                 170                 175     


Ile Ala Gln Ala His Ser Pro Ala Phe Ser Cys Glu Gln Val Arg Ala 
            180                 185                 190         


Phe Pro Ala Leu Xaa Ser Leu Asp Leu Ser Asp Asn Pro Gly Leu Gly 
        195                 200                 205             


Glu Arg Gly Leu Met Ala Ala Leu Cys Pro His Lys Phe Pro Ala Ile 
    210                 215                 220                 


Gln Asn Leu Ala Leu Arg Asn Xaa Gly Met Glu Xaa Pro Xaa Gly Val 
225                 230                 235                 240 


Cys Ala Ala Leu Ala Ala Ala Gly Val Gln Pro His Ser Leu Asp Leu 
                245                 250                 255     


Ser His Asn Ser Leu Arg Ala Xaa Val Asn Pro Ser Ala Pro Arg Cys 
            260                 265                 270         


Met Trp Ser Ser Ala Leu Asn Ser Leu Asn Leu Ser Phe Ala Gly Leu 
        275                 280                 285             


Glu Gln Val Pro Lys Gly Leu Pro Ala Lys Leu Arg Val Leu Asp Leu 
    290                 295                 300                 


Ser Cys Asn Arg Leu Asn Arg Ala Pro Gln Pro Asp Glu Leu Pro Glu 
305                 310                 315                 320 


Val Asp Asn Leu Xaa Leu Asp Gly Asn Pro Phe Leu Val Pro Gly Xaa 
                325                 330                 335     


Ala Leu Pro His Glu Gly Ser Met Asn Ser Gly Val Val Pro Ala Cys 
            340                 345                 350         


Ala Arg Ser Xaa Leu Ser Val Gly Val Ser Gly Xaa Leu Val Leu Leu 
        355                 360                 365             


Gln Gly Ala Arg Gly Phe Ala 
    370                 375 


<210> 5357
<211> 65
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<400> 5357
Met Gly Glu Phe Asn Glu Lys Lys Xaa Xaa Cys Gly Xaa Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Xaa Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Xaa Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Xaa Tyr Leu Ala Xaa Ala Tyr Ile Leu 
    50                  55                  60                  


Val 
65  


<210> 5358
<211> 79
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<400> 5358
Met Gly Glu Phe Asn Glu Lys Lys Xaa Xaa Cys Gly Xaa Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Xaa Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Xaa Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Xaa Tyr Leu Ala Xaa Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Xaa Val Val Met Val Xaa Gly Val Leu Gly Cys 
65                  70                  75                  


<210> 5359
<211> 90
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<400> 5359
Met Gly Glu Phe Asn Glu Lys Lys Xaa Xaa Cys Gly Xaa Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Xaa Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Xaa Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Xaa Tyr Leu Ala Xaa Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Xaa Val Val Met Val Xaa Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Xaa Phe Lys Glu Arg Arg Asn Leu Leu 
                85                  90  


<210> 5360
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<400> 5360
Met Gly Glu Phe Asn Glu Lys Lys Xaa Xaa Cys Gly Xaa Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Xaa Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Xaa Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Xaa Tyr Leu Ala Xaa Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Xaa Val Val Met Val Xaa Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Xaa Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu 
                85                  90          


<210> 5361
<211> 178
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 5361
Met Gly Glu Phe Asn Glu Lys Lys Xaa Xaa Cys Gly Xaa Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Xaa Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Xaa Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Xaa Tyr Leu Ala Xaa Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Xaa Val Val Met Val Xaa Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Xaa Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Leu Asn Xaa Glu 
                85                  90                  95      


Leu Lys Glu Asn Leu Lys Asp Xaa Met Xaa Lys Arg Tyr His Gln Pro 
            100                 105                 110         


Gly His Glu Ala Val Xaa Ser Ala Val Asp Gln Leu Gln Gln Glu Phe 
        115                 120                 125             


His Cys Cys Gly Ser Asn Asn Ser Gln Asp Trp Arg Asp Ser Glu Trp 
    130                 135                 140                 


Ile Arg Ser Gln Glu Ala Gly Gly Arg Val Val Pro Asp Ser Cys Cys 
145                 150                 155                 160 


Lys Xaa Val Val Ala Leu Cys Gly Gln Arg Asp His Ala Ser Asn Ile 
                165                 170                 175     


Tyr Lys 
        


<210> 5362
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<400> 5362
Met Gly Glu Phe Asn Glu Lys Lys Xaa Xaa Cys Gly Xaa Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Xaa Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Xaa Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Xaa Tyr Leu Ala Xaa Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Xaa Val Val Met Val Xaa Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Xaa Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Xaa Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Xaa Met Xaa Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Xaa Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile 
                165                 170 


<210> 5363
<211> 176
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<400> 5363
Met Gly Glu Phe Asn Glu Lys Lys Xaa Xaa Cys Gly Xaa Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Xaa Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Xaa Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Xaa Tyr Leu Ala Xaa Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Xaa Val Val Met Val Xaa Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Xaa Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Xaa Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Xaa Met Xaa Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Xaa Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


<210> 5364
<211> 180
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<400> 5364
Met Gly Glu Phe Asn Glu Lys Lys Xaa Xaa Cys Gly Xaa Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Xaa Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Xaa Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Xaa Tyr Leu Ala Xaa Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Xaa Val Val Met Val Xaa Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Xaa Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Xaa Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Xaa Met Xaa Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Xaa Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val 
            180 


<210> 5365
<211> 251
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<400> 5365
Met Gly Glu Phe Asn Glu Lys Lys Xaa Xaa Cys Gly Xaa Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Xaa Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Xaa Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Xaa Tyr Leu Ala Xaa Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Xaa Val Val Met Val Xaa Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Xaa Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Xaa Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Xaa Met Xaa Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Xaa Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Xaa Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Gly Gly Cys Ile Xaa 
        195                 200                 205             


Lys Leu Glu Xaa Phe Ile Gln Glu His Leu Arg Val Ile Gly Ala Val 
    210                 215                 220                 


Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe Xaa Cys 
225                 230                 235                 240 


Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr 
                245                 250     


<210> 5366
<211> 253
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<400> 5366
Met Gly Glu Phe Asn Glu Lys Lys Xaa Xaa Cys Gly Xaa Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Xaa Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Xaa Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Xaa Tyr Leu Ala Xaa Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Xaa Val Val Met Val Xaa Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Xaa Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Xaa Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Xaa Met Xaa Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Xaa Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Xaa Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Xaa Lys Leu Glu Xaa Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Xaa Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr 
                245                 250             


<210> 5367
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 5367
Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ile Val Asp Ile Gln Ser Gly Glu Xaa Gly Asn Tyr Xaa Val Xaa 
            20                  25                  30          


Gly Leu Lys Gln Arg Gln His Leu Glu Phe Ser His Asn Glu Gly Xaa 
        35                  40                  45              


Leu Ser Ser Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Xaa 
    50                  55                  60                  


Ser Leu Val Ala Leu Gln Ala Leu 
65                  70          


<210> 5368
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<400> 5368
Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ile Val Asp Ile Gln Ser Gly Glu Xaa Gly Asn Tyr Xaa Val Xaa 
            20                  25                  30          


Gly Leu Lys Gln Arg Gln His Leu Glu Phe Ser His Asn Glu Gly Xaa 
        35                  40                  45              


Leu Ser Ser Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Xaa 
    50                  55                  60                  


Ser Leu Val Ala Leu Gln Gly Met Ser Lys Arg Ala Val Ser Xaa Pro 
65                  70                  75                  80  


Ser Asn Glu Gly Ala Ile Ile Phe Leu Pro Pro Trp Leu Phe Ser Arg 
                85                  90                  95      


Arg Arg Arg Leu Glu Arg Met Ser Arg Gly Arg Glu Lys Cys Tyr Ser 
            100                 105                 110         


Ser Pro Gly Tyr Pro Gln Glu Ser Ser Asn Gln Phe His 
        115                 120                 125 


<210> 5369
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 5369
Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ile Val Asp Ile Gln Ser Gly Gly Cys Ile Asn Ile Xaa Ser Ser 
            20                  25                  30          


Ala Ser Gln Glu Gly Xaa Arg Leu Asn Leu Ile Cys Xaa Val Trp His 
        35                  40                  45              


Lys Lys Glu Glu Ala Glu Gly Phe Val Val Phe Leu Cys Lys Asp Arg 
    50                  55                  60                  


Ser Gly Asp Cys Ser Pro Glu Xaa Ser Leu Lys Gln Leu Arg Leu Lys 
65                  70                  75                  80  


Arg Asp Pro Gly Ile Asp Gly Val Gly Glu Ile Ser Ser Gln Leu Met 
                85                  90                  95      


Phe Xaa Ile Ser Gln Val Xaa Pro Leu His Ser Gly Xaa Tyr Gln Cys 
            100                 105                 110         


Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg Leu Gln Gly His Phe Phe 
        115                 120                 125             


Ser Ile Leu Phe Xaa Glu Xaa Gly Asn Tyr Xaa Val Xaa Gly Leu Lys 
    130                 135                 140                 


Gln Arg Gln His Leu Glu Phe Ser His Asn Glu Gly Xaa Leu Ser Ser 
145                 150                 155                 160 


Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Xaa Ser Leu Val 
                165                 170                 175     


Ala Leu Gln Ala Leu 
            180     


<210> 5370
<211> 234
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<400> 5370
Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ile Val Asp Ile Gln Ser Gly Gly Cys Ile Asn Ile Xaa Ser Ser 
            20                  25                  30          


Ala Ser Gln Glu Gly Xaa Arg Leu Asn Leu Ile Cys Xaa Val Trp His 
        35                  40                  45              


Lys Lys Glu Glu Ala Glu Gly Phe Val Val Phe Leu Cys Lys Asp Arg 
    50                  55                  60                  


Ser Gly Asp Cys Ser Pro Glu Xaa Ser Leu Lys Gln Leu Arg Leu Lys 
65                  70                  75                  80  


Arg Asp Pro Gly Ile Asp Gly Val Gly Glu Ile Ser Ser Gln Leu Met 
                85                  90                  95      


Phe Xaa Ile Ser Gln Val Xaa Pro Leu His Ser Gly Xaa Tyr Gln Cys 
            100                 105                 110         


Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg Leu Gln Gly His Phe Phe 
        115                 120                 125             


Ser Ile Leu Phe Xaa Glu Xaa Gly Asn Tyr Xaa Val Xaa Gly Leu Lys 
    130                 135                 140                 


Gln Arg Gln His Leu Glu Phe Ser His Asn Glu Gly Xaa Leu Ser Ser 
145                 150                 155                 160 


Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Xaa Ser Leu Val 
                165                 170                 175     


Ala Leu Gln Gly Met Ser Lys Arg Ala Val Ser Xaa Pro Ser Asn Glu 
            180                 185                 190         


Gly Ala Ile Ile Phe Leu Pro Pro Trp Leu Phe Ser Arg Arg Arg Arg 
        195                 200                 205             


Leu Glu Arg Met Ser Arg Gly Arg Glu Lys Cys Tyr Ser Ser Pro Gly 
    210                 215                 220                 


Tyr Pro Gln Glu Ser Ser Asn Gln Phe His 
225                 230                 


<210> 5371
<211> 163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 5371
Met Arg Lys Gly Arg Lys Val Pro Met Tyr Val Pro Gly Val Leu Arg 
1               5                   10                  15      


Xaa Tyr Pro Lys Ala Lys Leu Glu Glu Xaa Cys Glu Gly Arg Asn Ser 
            20                  25                  30          


Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Xaa Xaa Cys Phe Trp 
        35                  40                  45              


Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Xaa Val Ser 
    50                  55                  60                  


Asp Cys Gln Val Gly Asn Xaa Xaa Asp Phe Cys Ser Val Ser Xaa Ala 
65                  70                  75                  80  


Xaa Pro Val Pro Xaa Ala Asn Ser Xaa Ala Lys Pro Xaa Val Gln Pro 
                85                  90                  95      


Ser Pro Ser Xaa Xaa Ser Lys Xaa Val Xaa Xaa Ser Gly Xaa Xaa Asn 
            100                 105                 110         


Asn Xaa Val Xaa Pro Xaa Ser Gln Pro Val Arg Lys Ser Xaa Phe Asp 
        115                 120                 125             


Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Gly Val Gln Ala 
    130                 135                 140                 


Val Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu Arg Asn Tyr 
145                 150                 155                 160 


His Xaa Leu 
            


<210> 5372
<211> 184
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<400> 5372
Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Xaa Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Xaa Xaa Gln His Pro Asn 
            20                  25                  30          


Val Xaa Xaa Leu Ala Pro Ile Ser Asn Val Xaa Ser Ala Pro Val Xaa 
        35                  40                  45              


Ser Leu Pro Leu Val Xaa Xaa Pro Ala Pro Glu Xaa Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Xaa Xaa Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Xaa 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Xaa Xaa Asp Phe Cys Ser Ala Lys 
            100                 105                 110         


Pro Xaa Val Gln Pro Ser Pro Ser Xaa Xaa Ser Lys Xaa Val Xaa Xaa 
        115                 120                 125             


Ser Gly Xaa Xaa Asn Asn Xaa Val Xaa Pro Xaa Ser Gln Pro Val Arg 
    130                 135                 140                 


Lys Ser Xaa Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val 
145                 150                 155                 160 


Leu Gly Val Gln Ala Val Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser 
                165                 170                 175     


Lys Glu Arg Asn Tyr His Xaa Leu 
            180                 


<210> 5373
<211> 157
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 5373
Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Xaa Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Xaa Xaa Gln His Pro Asn 
            20                  25                  30          


Val Xaa Xaa Leu Ala Pro Ile Ser Asn Val Xaa Ser Ala Pro Val Xaa 
        35                  40                  45              


Ser Leu Pro Leu Val Xaa Xaa Pro Ala Pro Glu Xaa Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Xaa Xaa Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Xaa 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Xaa Xaa Asp Phe Cys Ser Val Ser 
            100                 105                 110         


Xaa Ala Xaa Pro Val Pro Xaa Ala Asn Ser Xaa Ala Lys Pro Xaa Val 
        115                 120                 125             


Gln Pro Ser Pro Ser Xaa Xaa Ser Lys Xaa Val Xaa Xaa Ser Glu Ile 
    130                 135                 140                 


Arg Cys His Xaa Arg Asn Tyr Ile Pro Asp Leu Lys Lys 
145                 150                 155         


<210> 5374
<211> 189
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<400> 5374
Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Xaa Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Xaa Xaa Gln His Pro Asn 
            20                  25                  30          


Val Xaa Xaa Leu Ala Pro Ile Ser Asn Val Xaa Ser Ala Pro Val Xaa 
        35                  40                  45              


Ser Leu Pro Leu Val Xaa Xaa Pro Ala Pro Glu Xaa Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Xaa Xaa Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Xaa 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Xaa Xaa Asp Phe Cys Ser Val Ser 
            100                 105                 110         


Xaa Ala Xaa Pro Val Pro Xaa Ala Asn Ser Xaa Ala Lys Pro Xaa Val 
        115                 120                 125             


Gln Pro Ser Pro Ser Xaa Xaa Ser Lys Xaa Val Xaa Xaa Ser Gly Xaa 
    130                 135                 140                 


Xaa Asn Asn Xaa Val Xaa Pro Xaa Ser Gln Pro Val Arg Lys Ser Xaa 
145                 150                 155                 160 


Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Glu Ile 
                165                 170                 175     


Arg Cys His Xaa Arg Asn Tyr Ile Pro Asp Leu Lys Lys 
            180                 185                 


<210> 5375
<211> 197
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<400> 5375
Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Xaa Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Xaa Xaa Gln His Pro Asn 
            20                  25                  30          


Val Xaa Xaa Leu Ala Pro Ile Ser Asn Val Xaa Ser Ala Pro Val Xaa 
        35                  40                  45              


Ser Leu Pro Leu Val Xaa Xaa Pro Ala Pro Glu Xaa Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Xaa Xaa Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Xaa 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Xaa Xaa Asp Phe Cys Ser Val Ser 
            100                 105                 110         


Xaa Ala Xaa Pro Val Pro Xaa Ala Asn Ser Xaa Ala Lys Pro Xaa Val 
        115                 120                 125             


Gln Pro Ser Pro Ser Xaa Xaa Ser Lys Xaa Val Xaa Xaa Ser Gly Xaa 
    130                 135                 140                 


Xaa Asn Asn Xaa Val Xaa Pro Xaa Ser Gln Pro Val Arg Lys Ser Xaa 
145                 150                 155                 160 


Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Gly Val 
                165                 170                 175     


Gln Ala Val Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu Arg 
            180                 185                 190         


Asn Tyr His Xaa Leu 
        195         


<210> 5376
<211> 178
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<400> 5376
Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Xaa Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Xaa Xaa Gln His Pro Asn 
            20                  25                  30          


Val Xaa Xaa Leu Ala Pro Ile Ser Asn Val Xaa Ser Ala Pro Val Xaa 
        35                  40                  45              


Ser Leu Pro Leu Val Xaa Xaa Pro Ala Pro Glu Xaa Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Xaa Xaa Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Xaa 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Xaa Xaa Asp Phe Cys Ser Val Ser 
            100                 105                 110         


Xaa Ala Xaa Pro Val Pro Xaa Ala Asn Ser Xaa Gly Xaa Xaa Asn Asn 
        115                 120                 125             


Xaa Val Xaa Pro Xaa Ser Gln Pro Val Arg Lys Ser Xaa Phe Asp Ala 
    130                 135                 140                 


Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Gly Val Gln Ala Val 
145                 150                 155                 160 


Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu Arg Asn Tyr His 
                165                 170                 175     


Xaa Leu 
        


<210> 5377
<211> 661
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<400> 5377
Met Ala Phe Asp Val Ser Cys Phe Phe Trp Val Val Leu Phe Ser Ala 
1               5                   10                  15      


Gly Cys Lys Val Ile Xaa Ser Trp Asp Gln Met Cys Ile Glu Lys Glu 
            20                  25                  30          


Ala Asn Lys Xaa Tyr Asn Cys Glu Asn Leu Gly Leu Ser Glu Ile Pro 
        35                  40                  45              


Asp Xaa Leu Pro Asn Xaa Xaa Glu Phe Leu Glu Phe Ser Phe Asn Phe 
    50                  55                  60                  


Leu Pro Xaa Ile His Asn Arg Xaa Phe Ser Arg Leu Met Asn Leu Xaa 
65                  70                  75                  80  


Phe Leu Asp Leu Xaa Arg Cys Gln Ile Asn Trp Ile His Glu Asp Xaa 
                85                  90                  95      


Phe Gln Ser His His Gln Leu Ser Xaa Leu Val Leu Xaa Gly Asn Pro 
            100                 105                 110         


Leu Ile Phe Met Ala Glu Xaa Ser Leu Asn Gly Pro Lys Ser Leu Lys 
        115                 120                 125             


His Leu Phe Leu Ile Gln Xaa Gly Ile Ser Asn Leu Glu Phe Ile Pro 
    130                 135                 140                 


Val His Asn Leu Glu Asn Leu Glu Ser Leu Tyr Leu Gly Ser Asn His 
145                 150                 155                 160 


Ile Ser Ser Ile Lys Phe Pro Lys Asp Phe Pro Ala Arg Asn Leu Lys 
                165                 170                 175     


Val Leu Asp Phe Gln Asn Asn Ala Ile His Tyr Ile Ser Arg Glu Asp 
            180                 185                 190         


Met Arg Ser Leu Glu Gln Ala Ile Asn Leu Ser Leu Asn Phe Asn Gly 
        195                 200                 205             


Asn Asn Val Lys Gly Ile Glu Leu Gly Ala Phe Asp Ser Xaa Ile Phe 
    210                 215                 220                 


Gln Ser Leu Asn Phe Gly Gly Xaa Pro Asn Leu Ser Val Ile Phe Asn 
225                 230                 235                 240 


Gly Leu Gln Asn Ser Xaa Xaa Gln Ser Leu Trp Leu Gly Xaa Phe Glu 
                245                 250                 255     


Asp Ile Asp Asp Glu Asp Ile Ser Ser Ala Met Leu Lys Gly Leu Cys 
            260                 265                 270         


Glu Met Ser Val Glu Ser Leu Asn Leu Gln Glu His Arg Phe Ser Asp 
        275                 280                 285             


Ile Ser Ser Xaa Xaa Phe Gln Cys Phe Xaa Gln Leu Gln Glu Leu Asp 
    290                 295                 300                 


Leu Xaa Ala Xaa His Leu Lys Gly Leu Pro Ser Gly Met Lys Gly Leu 
305                 310                 315                 320 


Asn Leu Leu Lys Lys Leu Val Leu Ser Val Asn His Phe Asp Gln Leu 
                325                 330                 335     


Cys Gln Ile Ser Ala Ala Asn Phe Pro Ser Leu Xaa His Leu Tyr Ile 
            340                 345                 350         


Arg Gly Asn Val Lys Lys Leu His Leu Gly Val Gly Cys Leu Glu Lys 
        355                 360                 365             


Leu Gly Asn Leu Gln Xaa Leu Asp Leu Ser His Asn Asp Ile Glu Ala 
    370                 375                 380                 


Ser Asp Cys Cys Ser Leu Gln Leu Lys Asn Leu Ser His Leu Gln Xaa 
385                 390                 395                 400 


Leu Asn Leu Ser His Asn Glu Pro Leu Gly Leu Gln Ser Gln Ala Phe 
                405                 410                 415     


Lys Glu Cys Pro Gln Leu Glu Leu Leu Asp Leu Ala Phe Xaa Arg Leu 
            420                 425                 430         


His Ile Asn Ala Pro Gln Ser Pro Phe Gln Asn Leu His Phe Leu Gln 
        435                 440                 445             


Val Leu Asn Leu Xaa Tyr Cys Phe Leu Asp Xaa Ser Asn Gln His Leu 
    450                 455                 460                 


Leu Ala Gly Leu Pro Val Leu Arg His Leu Asn Leu Lys Gly Asn His 
465                 470                 475                 480 


Phe Gln Asp Gly Xaa Ile Xaa Lys Xaa Asn Leu Leu Gln Xaa Val Gly 
                485                 490                 495     


Ser Leu Glu Val Leu Ile Leu Ser Ser Cys Gly Leu Leu Ser Ile Asp 
            500                 505                 510         


Gln Gln Ala Phe His Ser Leu Gly Lys Met Ser His Val Asp Leu Ser 
        515                 520                 525             


His Asn Ser Leu Xaa Cys Asp Ser Ile Asp Ser Leu Ser His Leu Lys 
    530                 535                 540                 


Gly Ile Tyr Leu Asn Leu Ala Ala Asn Ser Ile Asn Ile Ile Ser Pro 
545                 550                 555                 560 


Arg Leu Leu Pro Ile Leu Ser Gln Gln Ser Xaa Ile Asn Leu Ser His 
                565                 570                 575     


Asn Pro Leu Asp Cys Xaa Cys Ser Asn Ile His Phe Leu Xaa Trp Tyr 
            580                 585                 590         


Lys Glu Asn Leu His Lys Leu Glu Gly Ser Glu Glu Xaa Xaa Cys Ala 
        595                 600                 605             


Asn Pro Pro Ser Leu Arg Gly Val Lys Leu Ser Asp Val Lys Leu Ser 
    610                 615                 620                 


Cys Gly Ile Xaa Ala Ile Gly Ile Phe Phe Leu Ile Val Phe Leu Leu 
625                 630                 635                 640 


Leu Leu Ala Ile Leu Leu Phe Phe Ala Val Lys Tyr Leu Leu Arg Trp 
                645                 650                 655     


Lys Tyr Gln His Ile 
            660     


<210> 5378
<211> 556
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<400> 5378
Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Xaa Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Xaa Ser Asp Gly Pro Xaa Gln 
        35                  40                  45              


Gln Leu Xaa Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Xaa 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Xaa Met Ala Pro 
            180                 185                 190         


Gly Ser Xaa Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Xaa His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Xaa Gly Leu Leu Leu Pro Arg Ala Xaa Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Xaa Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Xaa Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Xaa Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Xaa Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Xaa Asp Pro Xaa Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Xaa Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Xaa Pro Xaa Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Xaa Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Xaa Gln Pro Val Ala Arg Xaa Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Xaa Ser Leu Gly 
                485                 490                 495     


Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro Gln 
            500                 505                 510         


Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp Ala 
        515                 520                 525             


Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala Trp 
    530                 535                 540                 


Gly Gly Gly Gly Arg Met Gly Xaa Trp Ser Xaa Arg 
545                 550                 555     


<210> 5379
<211> 557
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<400> 5379
Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Xaa Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Xaa Ser Asp Gly Pro Xaa Gln 
        35                  40                  45              


Gln Leu Xaa Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Xaa 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Xaa Met Ala Pro 
            180                 185                 190         


Gly Ser Xaa Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Xaa His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Xaa Gly Leu Leu Leu Pro Arg Ala Xaa Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Xaa Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Xaa Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Xaa Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Xaa Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Xaa Asp Pro Xaa Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Xaa Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Xaa Pro Xaa Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Xaa Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Xaa Gln Pro Val Ala Arg Xaa Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Xaa Ser Leu Ala 
                485                 490                 495     


Gly Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro 
            500                 505                 510         


Gln Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp 
        515                 520                 525             


Ala Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala 
    530                 535                 540                 


Trp Gly Gly Gly Gly Arg Met Gly Xaa Trp Ser Xaa Arg 
545                 550                 555         


<210> 5380
<211> 351
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<400> 5380
Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Xaa Asn Ala Leu Glu 
            20                  25                  30          


Xaa Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Xaa Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Xaa Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Xaa Tyr Lys Leu Phe Lys Asn Gly Xaa Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Xaa Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr Asp Xaa 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Xaa Cys Ile Asn Xaa Xaa Leu 
    130                 135                 140                 


Xaa Cys Glu Val Met Asn Gly Xaa Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Xaa His Lys Trp 
                165                 170                 175     


Xaa Xaa Ser Leu Ser Ala Lys Phe Lys Cys Xaa Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Xaa Lys Arg Lys Lys Gln 
225                 230                 235                 240 


Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Xaa Arg Ala His Arg Val 
                245                 250                 255     


Ala Xaa Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Xaa 
            260                 265                 270         


Pro Gln Asn Pro Ala Xaa Ser Gln His Pro Pro Pro Pro Pro Gly His 
        275                 280                 285             


Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val 
    290                 295                 300                 


Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Xaa Gln Val 
305                 310                 315                 320 


His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys 
                325                 330                 335     


Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn 
            340                 345                 350     


<210> 5381
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<400> 5381
Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Xaa Asn Ala Leu Glu 
            20                  25                  30          


Xaa Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Xaa Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Xaa Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Xaa Tyr Lys Leu Phe Lys Asn Gly Xaa Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Xaa Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr Asp Xaa 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Gly 
        115                 120                 125             


Lys Cys Ser Phe Pro 
    130             


<210> 5382
<211> 334
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<400> 5382
Met Ala Ser Ala Cys Pro Gly Ser Asp Phe Xaa Ser Ile His Ser Glu 
1               5                   10                  15      


Glu Glu Gln Leu Arg Gly Leu Gly Phe Arg Gln Xaa Arg Gly Tyr Lys 
            20                  25                  30          


Ser Leu Ala Val Ser Lys Val Pro Ser Ser Ile Ser Gln Glu Gln Ser 
        35                  40                  45              


Arg Gln Asp Ala Ile Tyr Gln Asn Leu Xaa Gln Leu Lys Ala Ala Val 
    50                  55                  60                  


Gly Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu 
65                  70                  75                  80  


Xaa Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu 
                85                  90                  95      


Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu 
            100                 105                 110         


Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Trp 
        115                 120                 125             


Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Met Gln Glu 
    130                 135                 140                 


Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu Pro 
145                 150                 155                 160 


Glu Lys Ser Lys Gln Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys 
                165                 170                 175     


Ala Ala Val Glu Arg Leu Cys His Pro Cys Pro Trp Glu Trp Xaa Phe 
            180                 185                 190         


Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn Ser Gln Arg Asn Trp His 
        195                 200                 205             


Asp Ser Ile Xaa Ala Cys Lys Glu Val Gly Ala Gln Leu Val Val Ile 
    210                 215                 220                 


Lys Ser Ala Glu Glu Gln Asn Phe Leu Gln Leu Gln Ser Ser Arg Ser 
225                 230                 235                 240 


Asn Arg Phe Xaa Trp Met Gly Leu Ser Asp Leu Asn Gln Glu Gly Xaa 
                245                 250                 255     


Trp Gln Trp Val Asp Gly Ser Pro Leu Leu Pro Ser Phe Lys Gln Tyr 
            260                 265                 270         


Trp Asn Arg Gly Glu Pro Asn Asn Val Gly Glu Glu Asp Cys Ala Glu 
        275                 280                 285             


Phe Ser Gly Asn Gly Trp Asn Asp Asp Lys Cys Asn Leu Ala Lys Phe 
    290                 295                 300                 


Trp Ile Cys Lys Lys Ser Ala Ala Ser Cys Ser Arg Asp Glu Glu Gln 
305                 310                 315                 320 


Phe Leu Ser Pro Ala Pro Ala Xaa Pro Asn Pro Pro Pro Ala 
                325                 330                 


<210> 5383
<211> 297
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<400> 5383
Met Ala Ser Ala Cys Pro Gly Ser Asp Phe Xaa Ser Ile His Ser Glu 
1               5                   10                  15      


Glu Glu Gln Leu Arg Gly Leu Gly Phe Arg Gln Xaa Arg Gly Tyr Lys 
            20                  25                  30          


Ser Leu Ala Val Ser Lys Val Pro Ser Ser Ile Ser Gln Glu Gln Ser 
        35                  40                  45              


Arg Gln Asp Ala Ile Tyr Gln Asn Leu Xaa Gln Leu Lys Ala Ala Val 
    50                  55                  60                  


Gly Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu 
65                  70                  75                  80  


Xaa Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu 
                85                  90                  95      


Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu 
            100                 105                 110         


Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Trp 
        115                 120                 125             


Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Met Gln Glu 
    130                 135                 140                 


Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu Pro 
145                 150                 155                 160 


Glu Lys Ser Lys Gln Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys 
                165                 170                 175     


Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gln Gln Glu Ile Tyr 
            180                 185                 190         


Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys 
        195                 200                 205             


Ser Lys Gln Gln Glu Ile Tyr Gln Glu Leu Xaa Gln Leu Lys Ala Ala 
    210                 215                 220                 


Val Glu Arg Leu Cys His Pro Cys Pro Trp Glu Trp Xaa Phe Phe Gln 
225                 230                 235                 240 


Gly Asn Cys Tyr Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp Ser 
                245                 250                 255     


Ile Xaa Ala Cys Lys Glu Val Gly Ala Gln Leu Val Val Ile Lys Ser 
            260                 265                 270         


Ala Glu Glu Gln Leu Gln Ala Val Leu Glu Gln Arg Arg Ala Gln Gln 
        275                 280                 285             


Arg Trp Gly Gly Arg Leu Arg Gly Ile 
    290                 295         


<210> 5384
<211> 380
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<400> 5384
Met Ala Ser Ala Cys Pro Gly Ser Asp Phe Xaa Ser Ile His Ser Glu 
1               5                   10                  15      


Glu Glu Gln Leu Arg Gly Leu Gly Phe Arg Gln Xaa Arg Gly Tyr Lys 
            20                  25                  30          


Ser Leu Ala Val Ser Lys Val Pro Ser Ser Ile Ser Gln Glu Gln Ser 
        35                  40                  45              


Arg Gln Asp Ala Ile Tyr Gln Asn Leu Xaa Gln Leu Lys Ala Ala Val 
    50                  55                  60                  


Gly Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu 
65                  70                  75                  80  


Xaa Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu 
                85                  90                  95      


Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu 
            100                 105                 110         


Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Trp 
        115                 120                 125             


Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Met Gln Glu 
    130                 135                 140                 


Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu Pro 
145                 150                 155                 160 


Glu Lys Ser Lys Gln Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys 
                165                 170                 175     


Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gln Gln Glu Ile Tyr 
            180                 185                 190         


Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys 
        195                 200                 205             


Ser Lys Gln Gln Glu Ile Tyr Gln Glu Leu Xaa Gln Leu Lys Ala Ala 
    210                 215                 220                 


Val Glu Arg Leu Cys His Pro Cys Pro Trp Glu Trp Xaa Phe Phe Gln 
225                 230                 235                 240 


Gly Asn Cys Tyr Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp Ser 
                245                 250                 255     


Ile Xaa Ala Cys Lys Glu Val Gly Ala Gln Leu Val Val Ile Lys Ser 
            260                 265                 270         


Ala Glu Glu Gln Asn Phe Leu Gln Leu Gln Ser Ser Arg Ser Asn Arg 
        275                 280                 285             


Phe Xaa Trp Met Gly Leu Ser Asp Leu Asn Gln Glu Gly Xaa Trp Gln 
    290                 295                 300                 


Trp Val Asp Gly Ser Pro Leu Leu Pro Ser Phe Lys Gln Tyr Trp Asn 
305                 310                 315                 320 


Arg Gly Glu Pro Asn Asn Val Gly Glu Glu Asp Cys Ala Glu Phe Ser 
                325                 330                 335     


Gly Asn Gly Trp Asn Asp Asp Lys Cys Asn Leu Ala Lys Phe Trp Ile 
            340                 345                 350         


Cys Lys Lys Ser Ala Ala Ser Cys Ser Arg Asp Glu Glu Gln Phe Leu 
        355                 360                 365             


Ser Pro Ala Pro Ala Xaa Pro Asn Pro Pro Pro Ala 
    370                 375                 380 


<210> 5385
<211> 243
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<400> 5385
Met Ser Asp Ser Lys Glu Pro Arg Leu Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Glu Gln Leu Arg Gly Leu Gly Phe Arg Gln Xaa Arg Gly Tyr Lys 
            20                  25                  30          


Ser Leu Ala Gly Cys Leu Gly His Gly Pro Leu Val Leu Gln Leu Leu 
        35                  40                  45              


Ser Phe Xaa Leu Leu Ala Gly Leu Leu Val Gln Val Ser Lys Val Pro 
    50                  55                  60                  


Ser Ser Ile Ser Gln Glu Gln Ser Arg Gln Asp Ala Ile Tyr Gln Asn 
65                  70                  75                  80  


Leu Xaa Gln Leu Lys Ala Ala Val Glu Arg Leu Cys His Pro Cys Pro 
                85                  90                  95      


Trp Glu Trp Xaa Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn Ser 
            100                 105                 110         


Gln Arg Asn Trp His Asp Ser Ile Xaa Ala Cys Lys Glu Val Gly Ala 
        115                 120                 125             


Gln Leu Val Val Ile Lys Ser Ala Glu Glu Gln Asn Phe Leu Gln Leu 
    130                 135                 140                 


Gln Ser Ser Arg Ser Asn Arg Phe Xaa Trp Met Gly Leu Ser Asp Leu 
145                 150                 155                 160 


Asn Gln Glu Gly Xaa Trp Gln Trp Val Asp Gly Ser Pro Leu Leu Pro 
                165                 170                 175     


Ser Phe Lys Gln Tyr Trp Asn Arg Gly Glu Pro Asn Asn Val Gly Glu 
            180                 185                 190         


Glu Asp Cys Ala Glu Phe Ser Gly Asn Gly Trp Asn Asp Asp Lys Cys 
        195                 200                 205             


Asn Leu Ala Lys Phe Trp Ile Cys Lys Lys Ser Ala Ala Ser Cys Ser 
    210                 215                 220                 


Arg Asp Glu Glu Gln Phe Leu Ser Pro Ala Pro Ala Xaa Pro Asn Pro 
225                 230                 235                 240 


Pro Pro Ala 
            


<210> 5386
<211> 312
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<400> 5386
Met Ser Asp Ser Lys Glu Pro Arg Leu Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Glu Gln Leu Arg Gly Leu Gly Phe Arg Gln Xaa Arg Gly Tyr Lys 
            20                  25                  30          


Ser Leu Ala Gly Cys Leu Gly His Gly Pro Leu Val Leu Gln Leu Leu 
        35                  40                  45              


Ser Phe Xaa Leu Leu Ala Gly Leu Leu Val Gln Val Ser Lys Val Pro 
    50                  55                  60                  


Ser Ser Ile Ser Gln Glu Gln Ser Arg Gln Asp Ala Ile Tyr Gln Asn 
65                  70                  75                  80  


Leu Xaa Gln Leu Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys 
                85                  90                  95      


Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Gln Leu Lys Ala Ala Val Gly 
            100                 105                 110         


Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa 
        115                 120                 125             


Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
    130                 135                 140                 


Glu Ile Tyr Gln Glu Leu Xaa Trp Leu Lys Ala Ala Val Glu Arg Leu 
145                 150                 155                 160 


Cys His Pro Cys Pro Trp Glu Trp Xaa Phe Phe Gln Gly Asn Cys Tyr 
                165                 170                 175     


Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp Ser Ile Xaa Ala Cys 
            180                 185                 190         


Lys Glu Val Gly Ala Gln Leu Val Val Ile Lys Ser Ala Glu Glu Gln 
        195                 200                 205             


Asn Phe Leu Gln Leu Gln Ser Ser Arg Ser Asn Arg Phe Xaa Trp Met 
    210                 215                 220                 


Gly Leu Ser Asp Leu Asn Gln Glu Gly Xaa Trp Gln Trp Val Asp Gly 
225                 230                 235                 240 


Ser Pro Leu Leu Pro Ser Phe Lys Gln Tyr Trp Asn Arg Gly Glu Pro 
                245                 250                 255     


Asn Asn Val Gly Glu Glu Asp Cys Ala Glu Phe Ser Gly Asn Gly Trp 
            260                 265                 270         


Asn Asp Asp Lys Cys Asn Leu Ala Lys Phe Trp Ile Cys Lys Lys Ser 
        275                 280                 285             


Ala Ala Ser Cys Ser Arg Asp Glu Glu Gln Phe Leu Ser Pro Ala Pro 
    290                 295                 300                 


Ala Xaa Pro Asn Pro Pro Pro Ala 
305                 310         


<210> 5387
<211> 398
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<400> 5387
Met Ser Asp Ser Lys Glu Pro Arg Leu Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Glu Gln Leu Arg Gly Leu Gly Phe Arg Gln Xaa Arg Gly Tyr Lys 
            20                  25                  30          


Ser Leu Ala Gly Cys Leu Gly His Gly Pro Leu Val Leu Gln Leu Leu 
        35                  40                  45              


Ser Phe Xaa Leu Leu Ala Gly Leu Leu Val Gln Val Ser Lys Val Pro 
    50                  55                  60                  


Ser Ser Ile Ser Gln Glu Gln Ser Arg Gln Asp Ala Ile Tyr Gln Asn 
65                  70                  75                  80  


Leu Xaa Gln Leu Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys 
                85                  90                  95      


Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Gln Leu Lys Ala Ala Val Gly 
            100                 105                 110         


Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa 
        115                 120                 125             


Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
    130                 135                 140                 


Glu Ile Tyr Gln Glu Leu Xaa Trp Leu Lys Ala Ala Val Gly Glu Leu 
145                 150                 155                 160 


Pro Glu Lys Ser Lys Met Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu 
                165                 170                 175     


Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gln Gln Glu Ile 
            180                 185                 190         


Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        195                 200                 205             


Lys Ser Lys Gln Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala 
    210                 215                 220                 


Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gln Gln Glu Ile Tyr Gln 
225                 230                 235                 240 


Glu Leu Xaa Gln Leu Lys Ala Ala Val Glu Arg Leu Cys His Pro Cys 
                245                 250                 255     


Pro Trp Glu Trp Xaa Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn 
            260                 265                 270         


Ser Gln Arg Asn Trp His Asp Ser Ile Xaa Ala Cys Lys Glu Val Gly 
        275                 280                 285             


Ala Gln Leu Val Val Ile Lys Ser Ala Glu Glu Gln Ser Ser Arg Ser 
    290                 295                 300                 


Asn Arg Phe Xaa Trp Met Gly Leu Ser Asp Leu Asn Gln Glu Gly Xaa 
305                 310                 315                 320 


Trp Gln Trp Val Asp Gly Ser Pro Leu Leu Pro Ser Phe Lys Gln Tyr 
                325                 330                 335     


Trp Asn Arg Gly Glu Pro Asn Asn Val Gly Glu Glu Asp Cys Ala Glu 
            340                 345                 350         


Phe Ser Gly Asn Gly Trp Asn Asp Asp Lys Cys Asn Leu Ala Lys Phe 
        355                 360                 365             


Trp Ile Cys Lys Lys Ser Ala Ala Ser Cys Ser Arg Asp Glu Glu Gln 
    370                 375                 380                 


Phe Leu Ser Pro Ala Pro Ala Xaa Pro Asn Pro Pro Pro Ala 
385                 390                 395             


<210> 5388
<211> 404
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<400> 5388
Met Ser Asp Ser Lys Glu Pro Arg Leu Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Glu Gln Leu Arg Gly Leu Gly Phe Arg Gln Xaa Arg Gly Tyr Lys 
            20                  25                  30          


Ser Leu Ala Gly Cys Leu Gly His Gly Pro Leu Val Leu Gln Leu Leu 
        35                  40                  45              


Ser Phe Xaa Leu Leu Ala Gly Leu Leu Val Gln Val Ser Lys Val Pro 
    50                  55                  60                  


Ser Ser Ile Ser Gln Glu Gln Ser Arg Gln Asp Ala Ile Tyr Gln Asn 
65                  70                  75                  80  


Leu Xaa Gln Leu Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys 
                85                  90                  95      


Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Gln Leu Lys Ala Ala Val Gly 
            100                 105                 110         


Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa 
        115                 120                 125             


Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
    130                 135                 140                 


Glu Ile Tyr Gln Glu Leu Xaa Trp Leu Lys Ala Ala Val Gly Glu Leu 
145                 150                 155                 160 


Pro Glu Lys Ser Lys Met Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu 
                165                 170                 175     


Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gln Gln Glu Ile 
            180                 185                 190         


Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        195                 200                 205             


Lys Ser Lys Gln Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala 
    210                 215                 220                 


Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gln Gln Glu Ile Tyr Gln 
225                 230                 235                 240 


Glu Leu Xaa Gln Leu Lys Ala Ala Val Glu Arg Leu Cys His Pro Cys 
                245                 250                 255     


Pro Trp Glu Trp Xaa Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn 
            260                 265                 270         


Ser Gln Arg Asn Trp His Asp Ser Ile Xaa Ala Cys Lys Glu Val Gly 
        275                 280                 285             


Ala Gln Leu Val Val Ile Lys Ser Ala Glu Glu Gln Asn Phe Leu Gln 
    290                 295                 300                 


Leu Gln Ser Ser Arg Ser Asn Arg Phe Xaa Trp Met Gly Leu Ser Asp 
305                 310                 315                 320 


Leu Asn Gln Glu Gly Xaa Trp Gln Trp Val Asp Gly Ser Pro Leu Leu 
                325                 330                 335     


Pro Ser Phe Lys Gln Tyr Trp Asn Arg Gly Glu Pro Asn Asn Val Gly 
            340                 345                 350         


Glu Glu Asp Cys Ala Glu Phe Ser Gly Asn Gly Trp Asn Asp Asp Lys 
        355                 360                 365             


Cys Asn Leu Ala Lys Phe Trp Ile Cys Lys Lys Ser Ala Ala Ser Cys 
    370                 375                 380                 


Ser Arg Asp Glu Glu Gln Phe Leu Ser Pro Ala Pro Ala Xaa Pro Asn 
385                 390                 395                 400 


Pro Pro Pro Ala 
                


<210> 5389
<211> 168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 5389
Met Ser Asp Ser Lys Glu Pro Arg Leu Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Glu Gln Leu Arg Gly Leu Gly Phe Arg Gln Xaa Arg Gly Tyr Lys 
            20                  25                  30          


Ser Leu Ala Gly Cys Leu Gly His Gly Pro Leu Val Leu Gln Leu Leu 
        35                  40                  45              


Ser Phe Xaa Leu Leu Ala Gly Leu Leu Val Gln Val Ser Lys Val Pro 
    50                  55                  60                  


Ser Ser Ile Ser Gln Glu Gln Ser Arg Ser Asn Arg Phe Xaa Trp Met 
65                  70                  75                  80  


Gly Leu Ser Asp Leu Asn Gln Glu Gly Xaa Trp Gln Trp Val Asp Gly 
                85                  90                  95      


Ser Pro Leu Leu Pro Ser Phe Lys Gln Tyr Trp Asn Arg Gly Glu Pro 
            100                 105                 110         


Asn Asn Val Gly Glu Glu Asp Cys Ala Glu Phe Ser Gly Asn Gly Trp 
        115                 120                 125             


Asn Asp Asp Lys Cys Asn Leu Ala Lys Phe Trp Ile Cys Lys Lys Ser 
    130                 135                 140                 


Ala Ala Ser Cys Ser Arg Asp Glu Glu Gln Phe Leu Ser Pro Ala Pro 
145                 150                 155                 160 


Ala Xaa Pro Asn Pro Pro Pro Ala 
                165             


<210> 5390
<211> 380
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<400> 5390
Met Ser Asp Ser Lys Glu Pro Arg Leu Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Glu Gln Leu Arg Gly Leu Gly Phe Arg Gln Xaa Arg Gly Tyr Lys 
            20                  25                  30          


Ser Leu Ala Val Ser Lys Val Pro Ser Ser Ile Ser Gln Glu Gln Ser 
        35                  40                  45              


Arg Gln Asp Ala Ile Tyr Gln Asn Leu Xaa Gln Leu Lys Ala Ala Val 
    50                  55                  60                  


Gly Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu 
65                  70                  75                  80  


Xaa Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu 
                85                  90                  95      


Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu 
            100                 105                 110         


Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Trp 
        115                 120                 125             


Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Met Gln Glu 
    130                 135                 140                 


Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu Pro 
145                 150                 155                 160 


Glu Lys Ser Lys Gln Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys 
                165                 170                 175     


Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gln Gln Glu Ile Tyr 
            180                 185                 190         


Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys 
        195                 200                 205             


Ser Lys Gln Gln Glu Ile Tyr Gln Glu Leu Xaa Gln Leu Lys Ala Ala 
    210                 215                 220                 


Val Glu Arg Leu Cys His Pro Cys Pro Trp Glu Trp Xaa Phe Phe Gln 
225                 230                 235                 240 


Gly Asn Cys Tyr Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp Ser 
                245                 250                 255     


Ile Xaa Ala Cys Lys Glu Val Gly Ala Gln Leu Val Val Ile Lys Ser 
            260                 265                 270         


Ala Glu Glu Gln Asn Phe Leu Gln Leu Gln Ser Ser Arg Ser Asn Arg 
        275                 280                 285             


Phe Xaa Trp Met Gly Leu Ser Asp Leu Asn Gln Glu Gly Xaa Trp Gln 
    290                 295                 300                 


Trp Val Asp Gly Ser Pro Leu Leu Pro Ser Phe Lys Gln Tyr Trp Asn 
305                 310                 315                 320 


Arg Gly Glu Pro Asn Asn Val Gly Glu Glu Asp Cys Ala Glu Phe Ser 
                325                 330                 335     


Gly Asn Gly Trp Asn Asp Asp Lys Cys Asn Leu Ala Lys Phe Trp Ile 
            340                 345                 350         


Cys Lys Lys Ser Ala Ala Ser Cys Ser Arg Asp Glu Glu Gln Phe Leu 
        355                 360                 365             


Ser Pro Ala Pro Ala Xaa Pro Asn Pro Pro Pro Ala 
    370                 375                 380 


<210> 5391
<211> 268
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<400> 5391
Met Ser Asp Ser Lys Glu Pro Arg Leu Gln Gln Leu Gly Leu Leu Val 
1               5                   10                  15      


Ser Lys Val Pro Ser Ser Ile Ser Gln Glu Gln Ser Arg Gln Asp Ala 
            20                  25                  30          


Ile Tyr Gln Asn Leu Xaa Gln Leu Lys Ala Ala Val Gly Glu Leu Ser 
        35                  40                  45              


Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Gln Leu Lys 
    50                  55                  60                  


Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr 
65                  70                  75                  80  


Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys 
                85                  90                  95      


Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Trp Leu Lys Ala Ala 
            100                 105                 110         


Val Glu Arg Leu Cys His Pro Cys Pro Trp Glu Trp Xaa Phe Phe Gln 
        115                 120                 125             


Gly Asn Cys Tyr Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp Ser 
    130                 135                 140                 


Ile Xaa Ala Cys Lys Glu Val Gly Ala Gln Leu Val Val Ile Lys Ser 
145                 150                 155                 160 


Ala Glu Glu Gln Asn Phe Leu Gln Leu Gln Ser Ser Arg Ser Asn Arg 
                165                 170                 175     


Phe Xaa Trp Met Gly Leu Ser Asp Leu Asn Gln Glu Gly Xaa Trp Gln 
            180                 185                 190         


Trp Val Asp Gly Ser Pro Leu Leu Pro Ser Phe Lys Gln Tyr Trp Asn 
        195                 200                 205             


Arg Gly Glu Pro Asn Asn Val Gly Glu Glu Asp Cys Ala Glu Phe Ser 
    210                 215                 220                 


Gly Asn Gly Trp Asn Asp Asp Lys Cys Asn Leu Ala Lys Phe Trp Ile 
225                 230                 235                 240 


Cys Lys Lys Ser Ala Ala Ser Cys Ser Arg Asp Glu Glu Gln Phe Leu 
                245                 250                 255     


Ser Pro Ala Pro Ala Xaa Pro Asn Pro Pro Pro Ala 
            260                 265             


<210> 5392
<211> 360
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<400> 5392
Met Ser Asp Ser Lys Glu Pro Arg Leu Gln Gln Leu Gly Leu Leu Val 
1               5                   10                  15      


Ser Lys Val Pro Ser Ser Ile Ser Gln Glu Gln Ser Arg Gln Asp Ala 
            20                  25                  30          


Ile Tyr Gln Asn Leu Xaa Gln Leu Lys Ala Ala Val Gly Glu Leu Ser 
        35                  40                  45              


Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Gln Leu Lys 
    50                  55                  60                  


Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr 
65                  70                  75                  80  


Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys 
                85                  90                  95      


Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Trp Leu Lys Ala Ala 
            100                 105                 110         


Val Gly Glu Leu Pro Glu Lys Ser Lys Met Gln Glu Ile Tyr Gln Glu 
        115                 120                 125             


Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys 
    130                 135                 140                 


Gln Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly 
145                 150                 155                 160 


Glu Leu Pro Glu Lys Ser Lys Gln Gln Glu Ile Tyr Gln Glu Leu Xaa 
                165                 170                 175     


Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gln Gln 
            180                 185                 190         


Glu Ile Tyr Gln Glu Leu Xaa Gln Leu Lys Ala Ala Val Glu Arg Leu 
        195                 200                 205             


Cys His Pro Cys Pro Trp Glu Trp Xaa Phe Phe Gln Gly Asn Cys Tyr 
    210                 215                 220                 


Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp Ser Ile Xaa Ala Cys 
225                 230                 235                 240 


Lys Glu Val Gly Ala Gln Leu Val Val Ile Lys Ser Ala Glu Glu Gln 
                245                 250                 255     


Asn Phe Leu Gln Leu Gln Ser Ser Arg Ser Asn Arg Phe Xaa Trp Met 
            260                 265                 270         


Gly Leu Ser Asp Leu Asn Gln Glu Gly Xaa Trp Gln Trp Val Asp Gly 
        275                 280                 285             


Ser Pro Leu Leu Pro Ser Phe Lys Gln Tyr Trp Asn Arg Gly Glu Pro 
    290                 295                 300                 


Asn Asn Val Gly Glu Glu Asp Cys Ala Glu Phe Ser Gly Asn Gly Trp 
305                 310                 315                 320 


Asn Asp Asp Lys Cys Asn Leu Ala Lys Phe Trp Ile Cys Lys Lys Ser 
                325                 330                 335     


Ala Ala Ser Cys Ser Arg Asp Glu Glu Gln Phe Leu Ser Pro Ala Pro 
            340                 345                 350         


Ala Xaa Pro Asn Pro Pro Pro Ala 
        355                 360 


<210> 5393
<211> 37
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<400> 5393
Ile Val Ile Pro Asp Val Xaa Val Ser Asp Ser Gly Leu Tyr Arg Cys 
1               5                   10                  15      


Tyr Leu Gln Ala Ser Ala Gly Glu Asn Glu Xaa Phe Val Met Arg Leu 
            20                  25                  30          


Xaa Val Ala Glu Gly 
        35          


<210> 5394
<211> 127
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 5394
Met Asp Tyr Pro Xaa Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Glu Glu Val Leu Trp His Xaa Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Xaa Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Xaa Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Xaa His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Xaa Met Ala Ser Asn Asn Met Xaa Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Xaa 
            100                 105                 110         


Tyr Pro Gln Gly Xaa Trp Gln Lys Val Ile Gln Val Val Gln Ser 
        115                 120                 125         


<210> 5395
<211> 132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 5395
Met Asp Tyr Pro Xaa Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Glu Glu Val Leu Trp His Xaa Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Xaa Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Xaa Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Xaa His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Xaa Met Ala Ser Asn Asn Met Xaa Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Xaa 
            100                 105                 110         


Tyr Pro Gln Gly Xaa Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp 
        115                 120                 125             


Ser Phe Glu Ala 
    130         


<210> 5396
<211> 276
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(269)
<223> Selenocysteine

<400> 5396
Met Asp Tyr Pro Xaa Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Glu Glu Val Leu Trp His Xaa Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Xaa Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Xaa Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Xaa His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Xaa Met Ala Ser Asn Asn Met Xaa Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Xaa 
            100                 105                 110         


Tyr Pro Gln Gly Xaa Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp 
        115                 120                 125             


Ser Phe Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro 
    130                 135                 140                 


Gly Lys Asn Val Xaa Leu Xaa Cys Gln Pro Gln Met Xaa Trp Pro Val 
145                 150                 155                 160 


Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu 
                165                 170                 175     


Xaa Tyr Cys Asn Leu Val His Gly Arg Asn Phe Xaa Ser Lys Phe Pro 
            180                 185                 190         


Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val 
        195                 200                 205             


Ile Pro Asp Val Xaa Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu 
    210                 215                 220                 


Gln Ala Ser Ala Gly Glu Asn Glu Xaa Phe Val Met Arg Leu Xaa Val 
225                 230                 235                 240 


Ala Glu Gly Lys Xaa Asp Asn Gln Tyr Xaa Leu Phe Val Ala Gly Gly 
                245                 250                 255     


Xaa Val Leu Leu Leu Leu Phe Val Ile Ser Ile Xaa Xaa Ile Ile Val 
            260                 265                 270         


Ile Phe Leu Asn 
        275     


<210> 5397
<211> 336
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<400> 5397
Met Asp Tyr Pro Xaa Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Glu Glu Val Leu Trp His Xaa Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Xaa Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Xaa Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Xaa His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Xaa Met Ala Ser Asn Asn Met Xaa Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Xaa 
            100                 105                 110         


Tyr Pro Gln Gly Xaa Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp 
        115                 120                 125             


Ser Phe Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro 
    130                 135                 140                 


Gly Lys Asn Val Xaa Leu Xaa Cys Gln Pro Gln Met Xaa Trp Pro Val 
145                 150                 155                 160 


Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu 
                165                 170                 175     


Xaa Tyr Cys Asn Leu Val His Gly Arg Asn Phe Xaa Ser Lys Phe Pro 
            180                 185                 190         


Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val 
        195                 200                 205             


Ile Pro Asp Val Xaa Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu 
    210                 215                 220                 


Gln Ala Ser Ala Gly Glu Asn Glu Xaa Phe Val Met Arg Leu Xaa Val 
225                 230                 235                 240 


Ala Glu Gly Lys Xaa Asp Asn Gln Tyr Xaa Leu Phe Val Ala Gly Gly 
                245                 250                 255     


Xaa Val Leu Leu Leu Leu Phe Val Ile Ser Ile Xaa Xaa Ile Ile Val 
            260                 265                 270         


Ile Phe Leu Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Xaa 
        275                 280                 285             


Glu Ser Trp Asp Xaa Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile 
    290                 295                 300                 


Ser Xaa Ser Gln Pro Xaa Asn Gln Ser Met Asp Asp Xaa Arg Glu Asp 
305                 310                 315                 320 


Ile Tyr Val Asn Tyr Pro Xaa Phe Ser Arg Arg Pro Lys Xaa Arg Val 
                325                 330                 335     


<210> 5398
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<400> 5398
Met Xaa Trp Pro Val Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg 
1               5                   10                  15      


Gln Ile Asp Leu Leu Xaa Tyr Cys Asn Leu Val His Gly Arg Asn Phe 
            20                  25                  30          


Xaa Ser Lys Phe Pro Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg 
        35                  40                  45              


Trp Ser Val Ile Val Ile Pro Asp Val Xaa Val Ser Asp Ser Gly Leu 
    50                  55                  60                  


Tyr Arg Cys Tyr Leu Gln Ala Ser Ala Gly Glu Asn Glu Xaa Phe Val 
65                  70                  75                  80  


Met Arg Leu Xaa Val Ala Glu Gly Lys Xaa Asp Asn Gln Tyr Xaa Leu 
                85                  90                  95      


Phe Val Ala Gly Gly Xaa Val Leu Leu Leu Leu Phe Val Ile Ser Ile 
            100                 105                 110         


Xaa Xaa Ile Ile Val Ile Phe Leu Asn Arg Arg Arg Arg Arg Glu Arg 
        115                 120                 125             


Arg Asp Leu Phe Xaa Glu Ser Trp Asp Xaa Gln Lys Ala Pro Asn Asn 
    130                 135                 140                 


Tyr Arg Ser Pro Ile Ser Xaa Ser Gln Pro Xaa Asn Gln Ser Met Asp 
145                 150                 155                 160 


Asp Xaa Arg Glu Asp Ile Tyr Val Asn Tyr Pro Xaa Phe Ser Arg Arg 
                165                 170                 175     


Pro Lys Xaa Arg Val 
            180     


<210> 5399
<211> 329
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<400> 5399
Met Leu Gly Gln Val Val Xaa Leu Ile Leu Leu Leu Leu Leu Lys Val 
1               5                   10                  15      


Tyr Gln Gly Lys Gly Cys Gln Gly Ser Ala Asp His Val Val Ser Ile 
            20                  25                  30          


Ser Gly Val Pro Leu Gln Leu Gln Pro Asn Ser Ile Gln Xaa Lys Val 
        35                  40                  45              


Asp Ser Ile Ala Trp Lys Lys Leu Leu Pro Ser Gln Asn Gly Phe His 
    50                  55                  60                  


His Ile Leu Lys Trp Glu Asn Gly Ser Leu Pro Ser Asn Xaa Ser Asn 
65                  70                  75                  80  


Asp Arg Phe Ser Phe Ile Val Lys Asn Leu Ser Leu Leu Ile Lys Ala 
                85                  90                  95      


Ala Gln Gln Gln Asp Ser Gly Leu Tyr Cys Leu Glu Val Xaa Ser Ile 
            100                 105                 110         


Ser Gly Lys Val Gln Xaa Ala Xaa Phe Gln Val Phe Val Phe Asp Lys 
        115                 120                 125             


Val Glu Lys Pro Arg Leu Gln Gly Gln Gly Lys Ile Leu Asp Arg Gly 
    130                 135                 140                 


Arg Cys Gln Val Ala Leu Ser Cys Leu Val Ser Arg Asp Gly Asn Val 
145                 150                 155                 160 


Ser Tyr Ala Trp Tyr Arg Gly Ser Lys Leu Ile Gln Xaa Ala Gly Asn 
                165                 170                 175     


Leu Xaa Tyr Leu Asp Glu Glu Val Asp Ile Asn Gly Xaa His Xaa Tyr 
            180                 185                 190         


Xaa Cys Asn Val Ser Asn Pro Val Ser Trp Glu Ser His Xaa Leu Asn 
        195                 200                 205             


Leu Xaa Gln Asp Cys Gln Asn Ala His Gln Glu Phe Arg Phe Trp Pro 
    210                 215                 220                 


Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu Phe Leu Gly Xaa Leu 
225                 230                 235                 240 


Ala Cys Phe Cys Val Trp Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu 
                245                 250                 255     


Xaa Ser Pro Lys Glu Phe Leu Xaa Ile Tyr Glu Asp Val Lys Asp Leu 
            260                 265                 270         


Lys Xaa Arg Arg Asn His Glu Gln Glu Gln Xaa Phe Pro Gly Gly Gly 
        275                 280                 285             


Ser Xaa Ile Tyr Ser Met Ile Gln Ser Gln Ser Ser Ala Pro Xaa Ser 
    290                 295                 300                 


Gln Glu Pro Ala Tyr Xaa Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys 
305                 310                 315                 320 


Gly Asp Arg Phe Tyr Ser Phe Ser Gly 
                325                 


<210> 5400
<211> 365
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<400> 5400
Met Leu Gly Gln Val Val Xaa Leu Ile Leu Leu Leu Leu Leu Lys Val 
1               5                   10                  15      


Tyr Gln Gly Lys Gly Cys Gln Gly Ser Ala Asp His Val Val Ser Ile 
            20                  25                  30          


Ser Gly Val Pro Leu Gln Leu Gln Pro Asn Ser Ile Gln Xaa Lys Val 
        35                  40                  45              


Asp Ser Ile Ala Trp Lys Lys Leu Leu Pro Ser Gln Asn Gly Phe His 
    50                  55                  60                  


His Ile Leu Lys Trp Glu Asn Gly Ser Leu Pro Ser Asn Xaa Ser Asn 
65                  70                  75                  80  


Asp Arg Phe Ser Phe Ile Val Lys Asn Leu Ser Leu Leu Ile Lys Ala 
                85                  90                  95      


Ala Gln Gln Gln Asp Ser Gly Leu Tyr Cys Leu Glu Val Xaa Ser Ile 
            100                 105                 110         


Ser Gly Lys Val Gln Xaa Ala Xaa Phe Gln Val Phe Val Phe Asp Lys 
        115                 120                 125             


Val Glu Lys Pro Arg Leu Gln Gly Gln Gly Lys Ile Leu Asp Arg Gly 
    130                 135                 140                 


Arg Cys Gln Val Ala Leu Ser Cys Leu Val Ser Arg Asp Gly Asn Val 
145                 150                 155                 160 


Ser Tyr Ala Trp Tyr Arg Gly Ser Lys Leu Ile Gln Xaa Ala Gly Asn 
                165                 170                 175     


Leu Xaa Tyr Leu Asp Glu Glu Val Asp Ile Asn Gly Xaa His Xaa Tyr 
            180                 185                 190         


Xaa Cys Asn Val Ser Asn Pro Val Ser Trp Glu Ser His Xaa Leu Asn 
        195                 200                 205             


Leu Xaa Gln Asp Cys Gln Asn Ala His Gln Glu Phe Arg Phe Trp Pro 
    210                 215                 220                 


Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu Phe Leu Gly Xaa Leu 
225                 230                 235                 240 


Ala Cys Phe Cys Val Trp Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu 
                245                 250                 255     


Xaa Ser Pro Lys Glu Phe Leu Xaa Ile Tyr Glu Asp Val Lys Asp Leu 
            260                 265                 270         


Lys Xaa Arg Arg Asn His Glu Gln Glu Gln Xaa Phe Pro Gly Gly Gly 
        275                 280                 285             


Ser Xaa Ile Tyr Ser Met Ile Gln Ser Gln Ser Ser Ala Pro Xaa Ser 
    290                 295                 300                 


Gln Glu Pro Ala Tyr Xaa Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys 
305                 310                 315                 320 


Ser Gly Ser Arg Lys Arg Asn His Ser Pro Ser Phe Asn Ser Xaa Ile 
                325                 330                 335     


Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg 
            340                 345                 350         


Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp Val Tyr Ser 
        355                 360                 365 


<210> 5401
<211> 273
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<400> 5401
Met Leu Gly Gln Val Val Xaa Leu Ile Leu Leu Leu Leu Leu Lys Val 
1               5                   10                  15      


Tyr Gln Gly Lys Gly Cys Gln Gly Ser Ala Asp His Val Val Ser Ile 
            20                  25                  30          


Ser Gly Val Pro Leu Gln Leu Gln Pro Asn Ser Ile Gln Xaa Lys Val 
        35                  40                  45              


Asp Ser Ile Ala Trp Lys Lys Leu Leu Pro Ser Gln Asn Gly Phe His 
    50                  55                  60                  


His Ile Leu Lys Trp Glu Asn Gly Ser Leu Pro Ser Asn Xaa Ser Asn 
65                  70                  75                  80  


Asp Arg Phe Ser Phe Ile Val Lys Asn Leu Ser Leu Leu Ile Lys Ala 
                85                  90                  95      


Ala Gln Gln Gln Asp Ser Gly Leu Tyr Cys Leu Glu Val Xaa Ser Ile 
            100                 105                 110         


Ser Gly Lys Val Gln Xaa Ala Xaa Phe Gln Val Phe Val Phe Glu Phe 
        115                 120                 125             


Arg Phe Trp Pro Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu Phe 
    130                 135                 140                 


Leu Gly Xaa Leu Ala Cys Phe Cys Val Trp Arg Arg Lys Arg Lys Glu 
145                 150                 155                 160 


Lys Gln Ser Glu Xaa Ser Pro Lys Glu Phe Leu Xaa Ile Tyr Glu Asp 
                165                 170                 175     


Val Lys Asp Leu Lys Xaa Arg Arg Asn His Glu Gln Glu Gln Xaa Phe 
            180                 185                 190         


Pro Gly Gly Gly Ser Xaa Ile Tyr Ser Met Ile Gln Ser Gln Ser Ser 
        195                 200                 205             


Ala Pro Xaa Ser Gln Glu Pro Ala Tyr Xaa Leu Tyr Ser Leu Ile Gln 
    210                 215                 220                 


Pro Ser Arg Lys Ser Gly Ser Arg Lys Arg Asn His Ser Pro Ser Phe 
225                 230                 235                 240 


Asn Ser Xaa Ile Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys Ala Gln 
                245                 250                 255     


Asn Pro Ala Arg Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp Val Tyr 
            260                 265                 270         


Ser 
    


<210> 5402
<211> 370
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<400> 5402
Met Leu Gly Gln Val Val Xaa Leu Ile Leu Leu Leu Leu Leu Lys Val 
1               5                   10                  15      


Tyr Gln Gly Lys Gly Cys Gln Gly Ser Ala Asp His Val Val Ser Ile 
            20                  25                  30          


Ser Gly Val Pro Leu Gln Leu Gln Pro Asn Ser Ile Gln Xaa Lys Val 
        35                  40                  45              


Asp Ser Ile Ala Trp Lys Lys Leu Leu Pro Ser Gln Asn Gly Phe His 
    50                  55                  60                  


His Ile Leu Lys Trp Glu Asn Gly Ser Leu Pro Ser Asn Xaa Ser Asn 
65                  70                  75                  80  


Asp Arg Phe Ser Phe Ile Val Lys Asn Leu Ser Leu Leu Ile Lys Ala 
                85                  90                  95      


Ala Gln Gln Gln Asp Ser Gly Leu Tyr Cys Leu Glu Val Xaa Ser Ile 
            100                 105                 110         


Ser Gly Lys Val Gln Xaa Ala Xaa Phe Gln Val Phe Val Phe Glu Ser 
        115                 120                 125             


Leu Leu Pro Asp Lys Val Glu Lys Pro Arg Leu Gln Gly Gln Gly Lys 
    130                 135                 140                 


Ile Leu Asp Arg Gly Arg Cys Gln Val Ala Leu Ser Cys Leu Val Ser 
145                 150                 155                 160 


Arg Asp Gly Asn Val Ser Tyr Ala Trp Tyr Arg Gly Ser Lys Leu Ile 
                165                 170                 175     


Gln Xaa Ala Gly Asn Leu Xaa Tyr Leu Asp Glu Glu Val Asp Ile Asn 
            180                 185                 190         


Gly Xaa His Xaa Tyr Xaa Cys Asn Val Ser Asn Pro Val Ser Trp Glu 
        195                 200                 205             


Ser His Xaa Leu Asn Leu Xaa Gln Asp Cys Gln Asn Ala His Gln Glu 
    210                 215                 220                 


Phe Arg Phe Trp Pro Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu 
225                 230                 235                 240 


Phe Leu Gly Xaa Leu Ala Cys Phe Cys Val Trp Arg Arg Lys Arg Lys 
                245                 250                 255     


Glu Lys Gln Ser Glu Xaa Ser Pro Lys Glu Phe Leu Xaa Ile Tyr Glu 
            260                 265                 270         


Asp Val Lys Asp Leu Lys Xaa Arg Arg Asn His Glu Gln Glu Gln Xaa 
        275                 280                 285             


Phe Pro Gly Gly Gly Ser Xaa Ile Tyr Ser Met Ile Gln Ser Gln Ser 
    290                 295                 300                 


Ser Ala Pro Xaa Ser Gln Glu Pro Ala Tyr Xaa Leu Tyr Ser Leu Ile 
305                 310                 315                 320 


Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys Arg Asn His Ser Pro Ser 
                325                 330                 335     


Phe Asn Ser Xaa Ile Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys Ala 
            340                 345                 350         


Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp Val 
        355                 360                 365             


Tyr Ser 
    370 


<210> 5403
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<400> 5403
Met Lys Trp Lys Ala Leu Phe Xaa Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Xaa Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Xaa Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Xaa Ala Xaa Lys Asp Xaa Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210> 5404
<211> 163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<400> 5404
Met Lys Trp Lys Ala Leu Phe Xaa Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Xaa Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Xaa Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Xaa Ala Xaa Lys Asp Xaa Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210> 5405
<211> 260
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<400> 5405
Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Xaa Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Xaa Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Xaa Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Xaa Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Xaa Ile Xaa Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Xaa Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Xaa Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Xaa His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Xaa Ala Gly His Met 
145                 150                 155                 160 


Gln Xaa Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Xaa Leu Ser Xaa 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Xaa Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Xaa Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro 
            260 


<210> 5406
<211> 290
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<400> 5406
Met Arg Ile Phe Ala Val Phe Ile Phe Met Xaa Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Xaa Val Xaa Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Xaa Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Xaa Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Xaa Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Xaa Ser Glu His Glu Leu Xaa Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Xaa Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Xaa Xaa Xaa Xaa Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Xaa Ser Xaa Leu Arg Ile Asn Xaa Xaa Xaa Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Xaa Phe Arg Arg Leu Asp Pro Glu Glu Asn His Xaa Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Xaa His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Xaa 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Xaa Asn Ser Lys Lys Gln Ser Asp Xaa His Leu Glu 
        275                 280                 285             


Glu Xaa 
    290 


<210> 5407
<211> 176
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<400> 5407
Met Arg Ile Phe Ala Val Phe Ile Phe Met Xaa Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
            20                  25                  30          


Val Xaa Ser Glu His Glu Leu Xaa Cys Gln Ala Glu Gly Tyr Pro Lys 
        35                  40                  45              


Ala Glu Val Ile Trp Xaa Ser Ser Asp His Gln Val Leu Ser Gly Lys 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Xaa 
65                  70                  75                  80  


Ser Xaa Leu Arg Ile Asn Xaa Xaa Xaa Asn Glu Ile Phe Tyr Cys Xaa 
                85                  90                  95      


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Xaa Ala Glu Leu Val Ile 
            100                 105                 110         


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Xaa His Leu Val 
        115                 120                 125             


Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Xaa Phe Ile 
    130                 135                 140                 


Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile 
145                 150                 155                 160 


Gln Asp Xaa Asn Ser Lys Lys Gln Ser Asp Xaa His Leu Glu Glu Xaa 
                165                 170                 175     


<210> 5408
<211> 101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<400> 5408
Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Xaa Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
            20                  25                  30          


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
        35                  40                  45              


Leu Leu Val Xaa Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
    50                  55                  60                  


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Xaa Pro Arg Arg Pro 
65                  70                  75                  80  


Gly Pro Xaa Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
                85                  90                  95      


Ala Ala Tyr Arg Ser 
            100     


<210> 5409
<211> 220
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<400> 5409
Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Xaa Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Xaa Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Xaa 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Xaa Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Xaa Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Xaa Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Xaa Pro Arg Arg Pro Gly Pro Xaa Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210> 5410
<211> 234
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<400> 5410
Met Pro Cys Gly Leu Ser Ala Leu Ile Met Cys Pro Lys Gly Met Val 
1               5                   10                  15      


Ala Val Val Val Ala Val Asp Asp Gly Asp Ser Gln Ala Leu Ala Gly 
            20                  25                  30          


Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn 
        35                  40                  45              


Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu 
    50                  55                  60                  


Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys 
65                  70                  75                  80  


Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Xaa 
                85                  90                  95      


Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Xaa Phe Tyr 
            100                 105                 110         


Leu Gln Asn Leu Tyr Val Asn Gln Xaa Asp Ile Tyr Phe Cys Lys Ile 
        115                 120                 125             


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
    130                 135                 140                 


Xaa Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
145                 150                 155                 160 


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Xaa Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
        195                 200                 205             


Xaa Pro Arg Arg Pro Gly Pro Xaa Arg Lys His Tyr Gln Pro Tyr Ala 
    210                 215                 220                 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
225                 230                 


<210> 5411
<211> 639
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<400> 5411
Met Val Asp Tyr Ile Val Glu Tyr Asp Tyr Asp Ala Val His Asp Asp 
1               5                   10                  15      


Glu Leu Xaa Ile Arg Val Gly Glu Ile Ile Arg Asn Val Lys Lys Leu 
            20                  25                  30          


Gln Glu Glu Gly Trp Leu Glu Gly Glu Leu Asn Gly Arg Arg Gly Met 
        35                  40                  45              


Phe Pro Asp Asn Phe Val Lys Glu Ile Lys Arg Glu Xaa Glu Phe Lys 
    50                  55                  60                  


Asp Asp Ser Leu Pro Ile Lys Arg Glu Arg His Gly Asn Val Ala Ser 
65                  70                  75                  80  


Leu Val Gln Arg Ile Ser Xaa Tyr Gly Leu Pro Ala Gly Gly Ile Gln 
                85                  90                  95      


Pro His Pro Gln Xaa Lys Asn Ile Lys Lys Lys Xaa Lys Lys Arg Gln 
            100                 105                 110         


Cys Lys Val Leu Phe Glu Tyr Ile Pro Gln Asn Glu Asp Glu Leu Glu 
        115                 120                 125             


Leu Lys Val Gly Asp Ile Ile Asp Ile Asn Glu Glu Val Glu Glu Gly 
    130                 135                 140                 


Trp Trp Ser Gly Xaa Leu Asn Asn Lys Leu Gly Leu Phe Pro Ser Asn 
145                 150                 155                 160 


Phe Val Lys Glu Leu Glu Val Xaa Asp Asp Gly Glu Xaa His Glu Ala 
                165                 170                 175     


Gln Asp Asp Ser Glu Xaa Val Leu Ala Gly Pro Xaa Ser Pro Ile Pro 
            180                 185                 190         


Ser Leu Gly Asn Val Ser Glu Xaa Ala Ser Gly Ser Val Xaa Gln Pro 
        195                 200                 205             


Lys Lys Ile Arg Gly Ile Gly Phe Gly Asp Ile Phe Lys Glu Gly Ser 
    210                 215                 220                 


Val Lys Leu Arg Xaa Arg Xaa Ser Ser Ser Glu Xaa Glu Glu Lys Lys 
225                 230                 235                 240 


Pro Glu Lys Pro Leu Ile Leu Gln Ser Leu Gly Pro Lys Xaa Gln Ser 
                245                 250                 255     


Val Glu Ile Xaa Lys Xaa Asp Xaa Glu Gly Lys Ile Lys Ala Lys Glu 
            260                 265                 270         


Tyr Cys Arg Xaa Leu Phe Ala Tyr Glu Gly Xaa Asn Glu Asp Glu Leu 
        275                 280                 285             


Xaa Phe Lys Glu Gly Glu Ile Ile His Leu Ile Ser Lys Glu Xaa Gly 
    290                 295                 300                 


Glu Ala Gly Trp Trp Arg Gly Glu Leu Asn Gly Lys Glu Gly Val Phe 
305                 310                 315                 320 


Pro Asp Asn Phe Ala Val Gln Ile Asn Glu Leu Asp Lys Asp Phe Pro 
                325                 330                 335     


Lys Pro Lys Lys Pro Pro Pro Pro Ala Lys Ala Pro Ala Pro Lys Pro 
            340                 345                 350         


Glu Leu Ile Ala Ala Glu Lys Lys Tyr Phe Ser Leu Lys Pro Glu Glu 
        355                 360                 365             


Lys Asp Glu Lys Ser Xaa Leu Glu Gln Lys Pro Ser Lys Pro Ala Ala 
    370                 375                 380                 


Pro Gln Val Pro Pro Lys Lys Pro Xaa Pro Pro Xaa Lys Ala Ser Asn 
385                 390                 395                 400 


Leu Leu Arg Ser Ser Gly Xaa Val Tyr Pro Lys Arg Pro Glu Lys Pro 
                405                 410                 415     


Val Pro Pro Pro Pro Pro Ile Ala Lys Ile Asn Gly Glu Val Ser Ser 
            420                 425                 430         


Ile Ser Ser Lys Phe Glu Xaa Glu Pro Val Ser Lys Leu Lys Leu Asp 
        435                 440                 445             


Ser Glu Gln Leu Pro Leu Arg Pro Lys Ser Val Asp Phe Asp Ser Leu 
    450                 455                 460                 


Xaa Val Arg Xaa Ser Lys Glu Xaa Asp Val Val Asn Phe Asp Asp Ile 
465                 470                 475                 480 


Ala Ser Ser Glu Asn Leu Leu His Leu Xaa Ala Asn Arg Pro Lys Met 
                485                 490                 495     


Pro Gly Arg Arg Leu Pro Gly Arg Phe Asn Gly Gly His Ser Pro Xaa 
            500                 505                 510         


His Ser Pro Glu Lys Ile Leu Lys Leu Pro Lys Glu Glu Asp Ser Ala 
        515                 520                 525             


Asn Leu Lys Pro Ser Glu Leu Lys Lys Asp Xaa Cys Tyr Ser Pro Lys 
    530                 535                 540                 


Pro Ser Val Tyr Leu Ser Xaa Pro Ser Ser Ala Ser Lys Ala Asn Xaa 
545                 550                 555                 560 


Xaa Ala Phe Leu Xaa Pro Leu Glu Ile Lys Ala Lys Val Glu Xaa Asp 
                565                 570                 575     


Asp Val Lys Lys Asn Ser Leu Asp Glu Leu Arg Ala Gln Ile Ile Glu 
            580                 585                 590         


Leu Leu Cys Ile Val Glu Ala Leu Lys Lys Asp His Gly Lys Glu Leu 
        595                 600                 605             


Glu Lys Leu Arg Lys Asp Leu Glu Glu Glu Lys Xaa Met Arg Ser Asn 
    610                 615                 620                 


Leu Glu Met Glu Ile Glu Lys Leu Lys Lys Ala Val Leu Ser Ser 
625                 630                 635                 


<210> 5412
<211> 169
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 5412
Met Xaa Pro Ala Ser Ile Xaa Ala Ala Lys Xaa Ser Xaa Ile Xaa Xaa 
1               5                   10                  15      


Ala Phe Pro Pro Val Ser Ser Xaa Xaa Leu Phe Ala Val Gly Ala Xaa 
            20                  25                  30          


His Ser Ala Ser Ile Gln Glu Glu Xaa Glu Glu Val Val Asn Ser Gln 
        35                  40                  45              


Leu Pro Leu Leu Leu Ser Leu Leu Ala Leu Leu Leu Leu Leu Leu Val 
    50                  55                  60                  


Gly Ala Ser Leu Leu Ala Trp Arg Met Phe Gln Lys Trp Ile Lys Ala 
65                  70                  75                  80  


Gly Asp His Ser Glu Leu Ser Gln Asn Pro Lys Gln Ala Ala Xaa Gln 
                85                  90                  95      


Ser Glu Leu His Tyr Ala Asn Leu Glu Leu Leu Met Trp Pro Leu Gln 
            100                 105                 110         


Glu Lys Pro Ala Pro Pro Arg Glu Val Glu Val Glu Tyr Ser Xaa Val 
        115                 120                 125             


Ala Ser Pro Arg Glu Glu Leu His Tyr Ala Ser Val Val Phe Asp Ser 
    130                 135                 140                 


Asn Xaa Asn Arg Ile Ala Ala Gln Arg Pro Arg Glu Glu Glu Pro Asp 
145                 150                 155                 160 


Ser Asp Tyr Ser Val Ile Arg Lys Xaa 
                165                 


<210> 5413
<211> 103
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 5413
Met Trp Leu Pro Trp Ala Leu Leu Leu Leu Trp Val Pro Ala Gly Asp 
1               5                   10                  15      


His Ser Glu Leu Ser Gln Asn Pro Lys Gln Ala Ala Xaa Gln Ser Glu 
            20                  25                  30          


Leu His Tyr Ala Asn Leu Glu Leu Leu Met Trp Pro Leu Gln Glu Lys 
        35                  40                  45              


Pro Ala Pro Pro Arg Glu Val Glu Val Glu Tyr Ser Xaa Val Ala Ser 
    50                  55                  60                  


Pro Arg Glu Glu Leu His Tyr Ala Ser Val Val Phe Asp Ser Asn Xaa 
65                  70                  75                  80  


Asn Arg Ile Ala Ala Gln Arg Pro Arg Glu Glu Glu Pro Asp Ser Asp 
                85                  90                  95      


Tyr Ser Val Ile Arg Lys Xaa 
            100             


<210> 5414
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<400> 5414
Met Trp Leu Pro Trp Ala Leu Leu Leu Leu Trp Val Pro Ala Ser Xaa 
1               5                   10                  15      


Ser Met Xaa Pro Ala Ser Ile Xaa Ala Ala Lys Xaa Ser Xaa Ile Xaa 
            20                  25                  30          


Xaa Ala Phe Pro Pro Val Ser Ser Xaa Xaa Leu Phe Ala Val Gly Ala 
        35                  40                  45              


Xaa His Ser Ala Ser Ile Gln Glu Glu Xaa Glu Glu Val Val Asn Ser 
    50                  55                  60                  


Gln Leu Pro Leu Leu Leu Ser Leu Leu Ala Leu Leu Leu Leu Leu Leu 
65                  70                  75                  80  


Val Gly Ala Ser Leu Leu Ala Trp Arg Met Phe Gln Lys Trp Ile Lys 
                85                  90                  95      


Ala Gly Asp His Ser Glu Leu Ser Gln Asn Pro Lys Gln Ala Ala Xaa 
            100                 105                 110         


Gln Ser Glu Leu His Tyr Ala Asn Leu Glu Leu Leu Met Trp Pro Leu 
        115                 120                 125             


Gln Glu Lys Pro Ala Pro Pro Arg Glu Val Glu Val Glu Tyr Ser Xaa 
    130                 135                 140                 


Val Ala Ser Pro Arg Glu Glu Leu His Tyr Ala Ser Val Val Phe Asp 
145                 150                 155                 160 


Ser Asn Xaa Asn Arg Ile Ala Ala Gln Arg Pro Arg Glu Glu Glu Pro 
                165                 170                 175     


Asp Ser Asp Tyr Ser Val Ile Arg Lys Xaa 
            180                 185     


<210> 5415
<211> 150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 5415
Met Trp Leu Pro Trp Ala Leu Leu Leu Leu Trp Val Pro Ala Ser Xaa 
1               5                   10                  15      


Ser Met Xaa Pro Ala Ser Ile Xaa Ala Ala Lys Xaa Ser Xaa Ile Xaa 
            20                  25                  30          


Xaa Ala Phe Pro Pro Val Ser Ser Xaa Xaa Leu Phe Ala Val Gly Ala 
        35                  40                  45              


Xaa His Ser Ala Ser Ile Gln Glu Glu Xaa Glu Glu Val Val Asn Ser 
    50                  55                  60                  


Gln Leu Pro Leu Leu Leu Ser Leu Leu Ala Leu Leu Leu Leu Leu Leu 
65                  70                  75                  80  


Val Gly Ala Ser Leu Leu Ala Trp Arg Met Phe Gln Lys Trp Ile Lys 
                85                  90                  95      


Ala Gly Asp His Ser Glu Leu Ser Gln Asn Pro Lys Gln Ala Ser Pro 
            100                 105                 110         


Arg Glu Glu Leu His Tyr Ala Ser Val Val Phe Asp Ser Asn Xaa Asn 
        115                 120                 125             


Arg Ile Ala Ala Gln Arg Pro Arg Glu Glu Glu Pro Asp Ser Asp Tyr 
    130                 135                 140                 


Ser Val Ile Arg Lys Xaa 
145                 150 


<210> 5416
<211> 299
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<400> 5416
Met Trp Leu Pro Trp Ala Leu Leu Leu Leu Trp Val Pro Gly Cys Phe 
1               5                   10                  15      


Ala Leu Ser Lys Cys Arg Xaa Val Ala Gly Pro Val Gly Gly Ser Leu 
            20                  25                  30          


Ser Val Gln Cys Pro Tyr Glu Lys Glu His Arg Xaa Leu Asn Lys Tyr 
        35                  40                  45              


Trp Cys Arg Pro Pro Gln Ile Phe Leu Cys Asp Lys Ile Val Glu Xaa 
    50                  55                  60                  


Lys Gly Ser Ala Gly Lys Arg Asn Gly Arg Val Ser Ile Arg Asp Ser 
65                  70                  75                  80  


Pro Ala Asn Leu Ser Phe Xaa Val Xaa Leu Glu Asn Leu Xaa Glu Glu 
                85                  90                  95      


Asp Ala Gly Xaa Tyr Trp Cys Gly Val Asp Xaa Pro Trp Leu Arg Asp 
            100                 105                 110         


Phe His Asp Pro Val Val Glu Val Glu Val Ser Val Phe Pro Ala Ser 
        115                 120                 125             


Xaa Ser Met Xaa Pro Ala Ser Ile Xaa Ala Ala Lys Xaa Ser Xaa Ile 
    130                 135                 140                 


Xaa Xaa Ala Phe Pro Pro Val Ser Ser Xaa Xaa Leu Phe Ala Val Gly 
145                 150                 155                 160 


Ala Xaa His Ser Ala Ser Ile Gln Glu Glu Xaa Glu Glu Val Val Asn 
                165                 170                 175     


Ser Gln Leu Pro Leu Leu Leu Ser Leu Leu Ala Leu Leu Leu Leu Leu 
            180                 185                 190         


Leu Val Gly Ala Ser Leu Leu Ala Trp Arg Met Phe Gln Lys Trp Ile 
        195                 200                 205             


Lys Ala Gly Asp His Ser Glu Leu Ser Gln Asn Pro Lys Gln Ala Ala 
    210                 215                 220                 


Xaa Gln Ser Glu Leu His Tyr Ala Asn Leu Glu Leu Leu Met Trp Pro 
225                 230                 235                 240 


Leu Gln Glu Lys Pro Ala Pro Pro Arg Glu Val Glu Val Glu Tyr Ser 
                245                 250                 255     


Xaa Val Ala Ser Pro Arg Glu Glu Leu His Tyr Ala Ser Val Val Phe 
            260                 265                 270         


Asp Ser Asn Xaa Asn Arg Ile Ala Ala Gln Arg Pro Arg Glu Glu Glu 
        275                 280                 285             


Pro Asp Ser Asp Tyr Ser Val Ile Arg Lys Xaa 
    290                 295                 


<210> 5417
<211> 224
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<400> 5417
Met Xaa Ala Arg Ala Trp Ala Ser Trp Arg Ser Ser Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Val Pro Gly Tyr Phe Pro Leu Ser His Pro Met Xaa Val Ala 
            20                  25                  30          


Gly Pro Val Gly Gly Ser Leu Ser Val Gln Cys Arg Tyr Glu Lys Glu 
        35                  40                  45              


His Arg Xaa Leu Asn Lys Phe Trp Cys Arg Pro Pro Gln Ile Leu Arg 
    50                  55                  60                  


Cys Asp Lys Ile Val Glu Xaa Lys Gly Ser Ala Gly Lys Arg Asn Gly 
65                  70                  75                  80  


Arg Val Ser Ile Arg Asp Ser Pro Ala Asn Leu Ser Phe Xaa Val Xaa 
                85                  90                  95      


Leu Glu Asn Leu Xaa Glu Glu Asp Ala Gly Xaa Tyr Trp Cys Gly Val 
            100                 105                 110         


Asp Xaa Pro Trp Leu Arg Asp Phe His Asp Pro Ile Val Glu Val Glu 
        115                 120                 125             


Val Ser Val Phe Pro Ala Gly Xaa Xaa Xaa Ala Ser Ser Pro Gln Ser 
    130                 135                 140                 


Ser Met Gly Xaa Ser Gly Pro Pro Xaa Lys Leu Pro Val His Xaa Trp 
145                 150                 155                 160 


Pro Ser Val Xaa Arg Lys Asp Ser Pro Glu Pro Ser Pro His Pro Gly 
                165                 170                 175     


Ser Leu Phe Ser Asn Val Arg Phe Leu Leu Leu Val Leu Leu Glu Leu 
            180                 185                 190         


Pro Leu Leu Leu Ser Met Leu Gly Ala Val Leu Trp Val Asn Arg Pro 
        195                 200                 205             


Gln Arg Ser Ser Arg Ser Arg Gln Asn Trp Pro Lys Gly Glu Asn Gln 
    210                 215                 220                 


<210> 5418
<211> 237
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<400> 5418
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Xaa His 
1               5                   10                  15      


Arg Pro Lys Ile Leu Ile Pro Gly Xaa Leu Glu Pro Gly His Ser Lys 
            20                  25                  30          


Asn Leu Xaa Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Xaa Pro Pro 
        35                  40                  45              


Ile Phe Ser Trp Leu Ser Ala Ala Pro Xaa Ser Leu Gly Pro Arg Xaa 
    50                  55                  60                  


Xaa His Ser Ser Val Leu Ile Ile Xaa Pro Arg Pro Gln Asp His Gly 
65                  70                  75                  80  


Xaa Asn Leu Xaa Cys Gln Val Lys Phe Ala Gly Ala Gly Val Xaa Xaa 
                85                  90                  95      


Glu Arg Xaa Ile Gln Leu Asn Val Xaa Tyr Val Pro Gln Asn Pro Xaa 
            100                 105                 110         


Xaa Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Xaa Arg Ala 
        115                 120                 125             


Gly Val Val His Gly Ala Ile Gly Gly Ala Gly Val Xaa Ala Leu Leu 
    130                 135                 140                 


Ala Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Xaa His Arg Arg 
145                 150                 155                 160 


Lys Ala Ala Arg Xaa Ala Val Gly Arg Asn Asp Xaa His Pro Xaa Xaa 
                165                 170                 175     


Gly Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro 
            180                 185                 190         


Xaa Glu Xaa Ser Ser Cys Ser Gly Ala Ala Pro Xaa Val Glu Met Asp 
        195                 200                 205             


Glu Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser 
    210                 215                 220                 


Lys Asp Xaa Ser Xaa Glu Tyr Ser Glu Val Arg Xaa Gln 
225                 230                 235         


<210> 5419
<211> 212
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<400> 5419
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Xaa His 
1               5                   10                  15      


Arg Pro Lys Ile Leu Ile Pro Gly Xaa Leu Glu Pro Gly His Ser Lys 
            20                  25                  30          


Asn Leu Xaa Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Xaa Pro Pro 
        35                  40                  45              


Ile Phe Ser Trp Leu Ser Ala Ala Pro Xaa Ser Leu Gly Pro Arg Xaa 
    50                  55                  60                  


Xaa His Ser Ser Val Leu Ile Ile Xaa Pro Arg Pro Gln Asp His Gly 
65                  70                  75                  80  


Xaa Asn Leu Xaa Cys Gln Val Lys Phe Ala Gly Ala Gly Val Xaa Xaa 
                85                  90                  95      


Glu Arg Xaa Ile Gln Leu Asn Val Xaa Tyr Val Pro Gln Asn Pro Xaa 
            100                 105                 110         


Xaa Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Xaa Arg Ala 
        115                 120                 125             


Gly Val Val His Gly Ala Ile Gly Gly Ala Gly Val Xaa Ala Leu Leu 
    130                 135                 140                 


Ala Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Xaa His Arg Arg 
145                 150                 155                 160 


Lys Ala Ala Arg Xaa Ala Val Gly Arg Asn Asp Xaa His Pro Xaa Xaa 
                165                 170                 175     


Gly Ser Ala Ser Pro Val Ser Asp Gly Ala Ser Trp His Pro Val Cys 
            180                 185                 190         


Pro Ala Asp Xaa Ser Ser Gln Cys Gly Pro Pro Ser Cys Pro Ile Gln 
        195                 200                 205             


His Phe Gln Asn 
    210         


<210> 5420
<211> 310
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(303)
<223> Selenocysteine

<400> 5420
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Xaa Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Xaa Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Xaa Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Xaa Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Xaa Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Xaa Asp Leu Xaa His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Xaa Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Xaa Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Xaa Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Xaa Ser Leu Gly Pro Arg Xaa Xaa 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Xaa Pro Arg Pro Gln Asp His Gly Xaa 
        195                 200                 205             


Asn Leu Xaa Cys Gln Val Lys Phe Ala Gly Ala Gly Val Xaa Xaa Glu 
    210                 215                 220                 


Arg Xaa Ile Gln Leu Asn Val Xaa Tyr Val Pro Gln Asn Pro Xaa Xaa 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Xaa Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Xaa Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Xaa His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Xaa Ala Val Gly Arg Asn Asp Xaa His Pro Xaa Xaa Gly 
    290                 295                 300                 


Ser Ala Ser Pro Val Arg 
305                 310 


<210> 5421
<211> 364
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<400> 5421
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Xaa Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Xaa Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Xaa Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Xaa Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Xaa Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Xaa Asp Leu Xaa His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Xaa Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Xaa Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Xaa Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Xaa Ser Leu Gly Pro Arg Xaa Xaa 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Xaa Pro Arg Pro Gln Asp His Gly Xaa 
        195                 200                 205             


Asn Leu Xaa Cys Gln Val Lys Phe Ala Gly Ala Gly Val Xaa Xaa Glu 
    210                 215                 220                 


Arg Xaa Ile Gln Leu Asn Val Xaa Tyr Val Pro Gln Asn Pro Xaa Xaa 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Xaa Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Xaa Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Xaa His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Xaa Ala Val Gly Arg Asn Asp Xaa His Pro Xaa Xaa Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Xaa 
305                 310                 315                 320 


Glu Xaa Ser Ser Cys Ser Gly Ala Ala Pro Xaa Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Xaa Ser Xaa Glu Tyr Ser Glu Val Arg Xaa Gln 
        355                 360                 


<210> 5422
<211> 227
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<400> 5422
Met Asp Phe Gly Pro Gly Arg Leu Phe Arg Phe Phe Ser Tyr Cys Val 
1               5                   10                  15      


Val Ala His Ile Gln Leu Ala Val Phe Phe Phe Ser Val Gly Ile Leu 
            20                  25                  30          


Glu Xaa Arg Ile Leu Leu Ala Asp Gly Ala Glu Phe Lys Lys Asp Arg 
        35                  40                  45              


Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala 
    50                  55                  60                  


Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val 
65                  70                  75                  80  


Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Xaa Glu Ile Ser 
                85                  90                  95      


Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu 
            100                 105                 110         


Gly Ile Leu Asp Phe Xaa Glu Gln Asp Val Ala Ser His Gln Ser Tyr 
        115                 120                 125             


Ser Gln Lys Xaa Leu Ile Ala Leu Val Xaa Ser Gly Ala Leu Leu Ala 
    130                 135                 140                 


Val Leu Gly Ile Xaa Gly Tyr Phe Leu Met Asn Arg Arg Ser Trp Ser 
145                 150                 155                 160 


Pro Xaa Gly Glu Arg Leu Gly Glu Asp Pro Tyr Tyr Xaa Glu Asn Gly 
                165                 170                 175     


Gly Gly Gln Gly Tyr Ser Ser Gly Pro Gly Xaa Ser Pro Glu Ala Gln 
            180                 185                 190         


Gly Lys Ala Ser Val Asn Arg Gly Ala Gln Glu Asn Gly Xaa Gly Gln 
        195                 200                 205             


Ala Xaa Ser Arg Asn Gly His Ser Ala Arg Gln His Val Val Ala Asp 
    210                 215                 220                 


Xaa Glu Leu 
225         


<210> 5423
<211> 328
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<400> 5423
Met Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Met Pro Arg Gly 
1               5                   10                  15      


Trp Xaa Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly Phe Met Ser 
            20                  25                  30          


Leu Asp Asn Asn Gly Xaa Ala Xaa Pro Glu Leu Pro Xaa Gln Gly Xaa 
        35                  40                  45              


Phe Ser Asn Val Ser Xaa Asn Val Ser Tyr Gln Glu Xaa Xaa Xaa Pro 
    50                  55                  60                  


Ser Xaa Leu Gly Ser Xaa Ser Leu His Pro Val Ser Gln His Gly Asn 
65                  70                  75                  80  


Glu Ala Xaa Xaa Asn Ile Xaa Glu Xaa Xaa Val Lys Phe Xaa Ser Xaa 
                85                  90                  95      


Ser Val Ile Xaa Ser Val Tyr Gly Asn Xaa Asn Ser Ser Val Gln Ser 
            100                 105                 110         


Gln Xaa Ser Val Ile Ser Xaa Val Phe Xaa Xaa Pro Ala Asn Val Ser 
        115                 120                 125             


Xaa Pro Glu Xaa Xaa Leu Lys Pro Ser Leu Ser Pro Gly Asn Val Ser 
    130                 135                 140                 


Asp Leu Ser Xaa Xaa Ser Xaa Ser Leu Ala Xaa Ser Pro Xaa Lys Pro 
145                 150                 155                 160 


Tyr Xaa Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile Lys 
                165                 170                 175     


Cys Ser Gly Ile Arg Glu Val Lys Leu Xaa Gln Gly Ile Cys Leu Glu 
            180                 185                 190         


Gln Asn Lys Xaa Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly Glu 
        195                 200                 205             


Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp Ala 
    210                 215                 220                 


Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg Pro 
225                 230                 235                 240 


Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Xaa Glu Ile Ser Ser Lys 
                245                 250                 255     


Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly Ile 
            260                 265                 270         


Leu Asp Phe Xaa Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser Gln 
        275                 280                 285             


Lys Xaa Leu Ile Ala Leu Val Xaa Ser Gly Ala Leu Leu Ala Val Leu 
    290                 295                 300                 


Gly Ile Xaa Gly Tyr Phe Leu Met Asn Arg Arg Ser Trp Ser Pro Xaa 
305                 310                 315                 320 


Gly Glu Arg Leu Glu Leu Glu Pro 
                325             


<210> 5424
<211> 385
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<400> 5424
Met Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Met Pro Arg Gly 
1               5                   10                  15      


Trp Xaa Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly Phe Met Ser 
            20                  25                  30          


Leu Asp Asn Asn Gly Xaa Ala Xaa Pro Glu Leu Pro Xaa Gln Gly Xaa 
        35                  40                  45              


Phe Ser Asn Val Ser Xaa Asn Val Ser Tyr Gln Glu Xaa Xaa Xaa Pro 
    50                  55                  60                  


Ser Xaa Leu Gly Ser Xaa Ser Leu His Pro Val Ser Gln His Gly Asn 
65                  70                  75                  80  


Glu Ala Xaa Xaa Asn Ile Xaa Glu Xaa Xaa Val Lys Phe Xaa Ser Xaa 
                85                  90                  95      


Ser Val Ile Xaa Ser Val Tyr Gly Asn Xaa Asn Ser Ser Val Gln Ser 
            100                 105                 110         


Gln Xaa Ser Val Ile Ser Xaa Val Phe Xaa Xaa Pro Ala Asn Val Ser 
        115                 120                 125             


Xaa Pro Glu Xaa Xaa Leu Lys Pro Ser Leu Ser Pro Gly Asn Val Ser 
    130                 135                 140                 


Asp Leu Ser Xaa Xaa Ser Xaa Ser Leu Ala Xaa Ser Pro Xaa Lys Pro 
145                 150                 155                 160 


Tyr Xaa Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile Lys 
                165                 170                 175     


Cys Ser Gly Ile Arg Glu Val Lys Leu Xaa Gln Gly Ile Cys Leu Glu 
            180                 185                 190         


Gln Asn Lys Xaa Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly Glu 
        195                 200                 205             


Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp Ala 
    210                 215                 220                 


Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg Pro 
225                 230                 235                 240 


Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Xaa Glu Ile Ser Ser Lys 
                245                 250                 255     


Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly Ile 
            260                 265                 270         


Leu Asp Phe Xaa Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser Gln 
        275                 280                 285             


Lys Xaa Leu Ile Ala Leu Val Xaa Ser Gly Ala Leu Leu Ala Val Leu 
    290                 295                 300                 


Gly Ile Xaa Gly Tyr Phe Leu Met Asn Arg Arg Ser Trp Ser Pro Xaa 
305                 310                 315                 320 


Gly Glu Arg Leu Gly Glu Asp Pro Tyr Tyr Xaa Glu Asn Gly Gly Gly 
                325                 330                 335     


Gln Gly Tyr Ser Ser Gly Pro Gly Xaa Ser Pro Glu Ala Gln Gly Lys 
            340                 345                 350         


Ala Ser Val Asn Arg Gly Ala Gln Glu Asn Gly Xaa Gly Gln Ala Xaa 
        355                 360                 365             


Ser Arg Asn Gly His Ser Ala Arg Gln His Val Val Ala Asp Xaa Glu 
    370                 375                 380                 


Leu 
385 


<210> 5425
<211> 65
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<400> 5425
Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Xaa Ile Lys Lys Gln Val Val Leu Glu Glu Gly Xaa 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Xaa Gly Xaa Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe 
65  


<210> 5426
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 5426
Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Xaa Ile Lys Lys Gln Val Val Leu Glu Glu Gly Xaa 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Xaa Gly Xaa Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Cys Ile Pro Tyr Leu Ser Lys Ser Ile Cys Ser Asn Asp Pro Gln 
                85                  90                  95      


Phe Xaa Tyr 
            


<210> 5427
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 5427
Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Xaa Ile Lys Lys Gln Val Val Leu Glu Glu Gly Xaa 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Xaa Gly Xaa Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Xaa Tyr 
                85                  90              


<210> 5428
<211> 143
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 5428
Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Xaa Ile Lys Lys Gln Val Val Leu Glu Glu Gly Xaa 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Xaa Gly Xaa Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Xaa Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Xaa Gln Asp Ala Glu Asp Asn Xaa Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Xaa Glu Ala Asp Asn Phe Xaa Val Leu Asn Leu Ala Val Ala 
    130                 135                 140             


<210> 5429
<211> 148
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 5429
Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Xaa Ile Lys Lys Gln Val Val Leu Glu Glu Gly Xaa 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Xaa Gly Xaa Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Xaa Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Xaa Gln Asp Ala Glu Asp Asn Xaa Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Xaa Glu Ala Asp Asn Phe Xaa Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile 
145             


<210> 5430
<211> 203
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(197)
<223> Selenocysteine

<400> 5430
Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Xaa Ile Lys Lys Gln Val Val Leu Glu Glu Gly Xaa 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Xaa Gly Xaa Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Xaa Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Xaa Gln Asp Ala Glu Asp Asn Xaa Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Xaa Glu Ala Asp Asn Phe Xaa Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Xaa Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Xaa Xaa Xaa Val Gly Leu Phe Tyr Pro 
        195                 200             


<210> 5431
<211> 288
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<400> 5431
Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Xaa Ile Lys Lys Gln Val Val Leu Glu Glu Gly Xaa 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Xaa Gly Xaa Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Xaa Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Xaa Gln Asp Ala Glu Asp Asn Xaa Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Xaa Glu Ala Asp Asn Phe Xaa Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Xaa Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Xaa Xaa Xaa Val Gly Leu Phe Tyr Pro Tyr Asn Asn Xaa Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Xaa Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Xaa Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Glu Xaa Cys Val His Phe Xaa Ser Ser Phe Ser Val Cys Lys Ser 
        275                 280                 285             


<210> 5432
<211> 463
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<400> 5432
Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Xaa Ile Lys Lys Gln Val Val Leu Glu Glu Gly Xaa 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Xaa Gly Xaa Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Xaa Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Xaa Gln Asp Ala Glu Asp Asn Xaa Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Xaa Glu Ala Asp Asn Phe Xaa Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Xaa Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Xaa Xaa Xaa Val Gly Leu Phe Tyr Pro Tyr Asn Asn Xaa Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Xaa Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Xaa Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Xaa Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Xaa Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Xaa Tyr Leu Asp Ile Glu Pro Ile Xaa Gly Phe Xaa Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Xaa Gly Xaa Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Xaa Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr 
    450                 455                 460             


<210> 5433
<211> 472
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<400> 5433
Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Xaa Ile Lys Lys Gln Val Val Leu Glu Glu Gly Xaa 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Xaa Gly Xaa Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Xaa Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Xaa Gln Asp Ala Glu Asp Asn Xaa Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Xaa Glu Ala Asp Asn Phe Xaa Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Xaa Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Xaa Xaa Xaa Val Gly Leu Phe Tyr Pro Tyr Asn Asn Xaa Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Xaa Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Xaa Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Xaa Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Xaa Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Xaa Tyr Leu Asp Ile Glu Pro Ile Xaa Gly Phe Xaa Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Xaa Gly Xaa Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Xaa Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Xaa Ile Lys 
465                 470         


<210> 5434
<211> 433
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<400> 5434
Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Xaa Ile Lys Lys Gln Val Val Leu Glu Glu Gly Xaa 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Xaa Gly Xaa Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Xaa Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Xaa Gln Asp Ala Glu Asp Asn Xaa Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Xaa Glu Ala Asp Asn Phe Xaa Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Xaa Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Xaa Xaa Xaa Val Gly Leu Phe Tyr Pro Tyr Asn Asn Xaa Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Xaa Tyr Lys Gly Lys Arg Ser Ile Tyr Ala Val Phe 
225                 230                 235                 240 


Glu Ser Asp Val Asn Leu Lys Gly Ile Pro Val Tyr Arg Phe Val Leu 
                245                 250                 255     


Pro Ser Lys Ala Phe Ala Ser Pro Val Glu Asn Pro Asp Asn Tyr Cys 
            260                 265                 270         


Phe Cys Xaa Glu Lys Ile Ile Ser Lys Asn Cys Xaa Ser Tyr Gly Val 
        275                 280                 285             


Leu Asp Ile Ser Lys Cys Lys Glu Gly Arg Pro Val Tyr Ile Ser Leu 
    290                 295                 300                 


Pro His Phe Leu Tyr Ala Ser Pro Asp Val Ser Glu Pro Ile Asp Gly 
305                 310                 315                 320 


Leu Asn Pro Asn Glu Glu Glu His Arg Xaa Tyr Leu Asp Ile Glu Pro 
                325                 330                 335     


Ile Xaa Gly Phe Xaa Leu Gln Phe Ala Lys Arg Leu Gln Val Asn Leu 
            340                 345                 350         


Leu Val Lys Pro Ser Glu Lys Ile Gln Val Leu Lys Asn Leu Lys Arg 
        355                 360                 365             


Asn Tyr Ile Val Pro Ile Leu Trp Leu Asn Glu Xaa Gly Xaa Ile Gly 
    370                 375                 380                 


Asp Glu Lys Ala Asn Met Phe Arg Ser Gln Val Xaa Gly Lys Ile Asn 
385                 390                 395                 400 


Leu Leu Gly Leu Ile Glu Met Ile Leu Leu Ser Val Gly Val Val Met 
                405                 410                 415     


Phe Val Ala Phe Met Ile Ser Tyr Cys Ala Cys Arg Ser Lys Xaa Ile 
            420                 425                 430         


Lys 
    


<210> 5435
<211> 412
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<400> 5435
Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Xaa Ile Lys Lys Gln Val Val Leu Glu Glu Gly Xaa 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Xaa Gly Xaa Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Xaa Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Xaa Gln Asp Ala Glu Asp Asn Xaa Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Xaa Glu Ala Asp Asn Phe Xaa Val Leu Asn Leu Ala Val Ala Tyr 
    130                 135                 140                 


Asn Asn Xaa Ala Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn 
145                 150                 155                 160 


Ile Ser Lys Val Ala Ile Ile Asp Xaa Tyr Lys Gly Lys Arg Asn Leu 
                165                 170                 175     


Ser Tyr Trp Glu Ser His Cys Asp Met Ile Asn Gly Xaa Asp Ala Ala 
            180                 185                 190         


Ser Phe Pro Pro Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser 
        195                 200                 205             


Ser Asp Ile Cys Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn 
    210                 215                 220                 


Leu Lys Gly Ile Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe 
225                 230                 235                 240 


Ala Ser Pro Val Glu Asn Pro Asp Asn Tyr Cys Phe Cys Xaa Glu Lys 
                245                 250                 255     


Ile Ile Ser Lys Asn Cys Xaa Ser Tyr Gly Val Leu Asp Ile Ser Lys 
            260                 265                 270         


Cys Lys Glu Gly Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr 
        275                 280                 285             


Ala Ser Pro Asp Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu 
    290                 295                 300                 


Glu Glu His Arg Xaa Tyr Leu Asp Ile Glu Pro Ile Xaa Gly Phe Xaa 
305                 310                 315                 320 


Leu Gln Phe Ala Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser 
                325                 330                 335     


Glu Lys Ile Gln Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro 
            340                 345                 350         


Ile Leu Trp Leu Asn Glu Xaa Gly Xaa Ile Gly Asp Glu Lys Ala Asn 
        355                 360                 365             


Met Phe Arg Ser Gln Val Xaa Gly Lys Ile Asn Leu Leu Gly Leu Ile 
    370                 375                 380                 


Glu Met Ile Leu Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met 
385                 390                 395                 400 


Ile Ser Tyr Cys Ala Cys Arg Ser Lys Xaa Ile Lys 
                405                 410         


<210> 5436
<211> 396
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<400> 5436
Met Met Asn Ser Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Xaa 
1               5                   10                  15      


Tyr Arg Val Arg Phe Leu Ala Lys Glu Asn Val Xaa Gln Asp Ala Glu 
            20                  25                  30          


Asp Asn Xaa Val Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro 
        35                  40                  45              


Ser Leu Ser Val Gly Xaa Glu Ala Asp Asn Phe Xaa Val Leu Asn Leu 
    50                  55                  60                  


Ala Val Ala Ala Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met 
65                  70                  75                  80  


Ile Leu Asn Ser Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val 
                85                  90                  95      


Arg Xaa Leu Arg Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser 
            100                 105                 110         


Leu Val Pro Tyr Pro Val Xaa Xaa Xaa Val Gly Leu Phe Tyr Pro Tyr 
        115                 120                 125             


Asn Asn Xaa Ala Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn 
    130                 135                 140                 


Ile Ser Lys Val Ala Ile Ile Asp Xaa Tyr Lys Gly Lys Arg Asn Leu 
145                 150                 155                 160 


Ser Tyr Trp Glu Ser His Cys Asp Met Ile Asn Gly Xaa Asp Ala Ala 
                165                 170                 175     


Ser Phe Pro Pro Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser 
            180                 185                 190         


Ser Asp Ile Cys Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn 
        195                 200                 205             


Leu Lys Gly Ile Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe 
    210                 215                 220                 


Ala Ser Pro Val Glu Asn Pro Asp Asn Tyr Cys Phe Cys Xaa Glu Lys 
225                 230                 235                 240 


Ile Ile Ser Lys Asn Cys Xaa Ser Tyr Gly Val Leu Asp Ile Ser Lys 
                245                 250                 255     


Cys Lys Glu Gly Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr 
            260                 265                 270         


Ala Ser Pro Asp Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu 
        275                 280                 285             


Glu Glu His Arg Xaa Tyr Leu Asp Ile Glu Pro Ile Xaa Gly Phe Xaa 
    290                 295                 300                 


Leu Gln Phe Ala Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser 
305                 310                 315                 320 


Glu Lys Ile Gln Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro 
                325                 330                 335     


Ile Leu Trp Leu Asn Glu Xaa Gly Xaa Ile Gly Asp Glu Lys Ala Asn 
            340                 345                 350         


Met Phe Arg Ser Gln Val Xaa Gly Lys Ile Asn Leu Leu Gly Leu Ile 
        355                 360                 365             


Glu Met Ile Leu Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met 
    370                 375                 380                 


Ile Ser Tyr Cys Ala Cys Arg Ser Lys Xaa Ile Lys 
385                 390                 395     


<210> 5437
<211> 66
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 5437
Xaa Asn Tyr Ile Val Pro Ile Leu Trp Leu Asn Glu Xaa Gly Xaa Ile 
1               5                   10                  15      


Gly Asp Glu Lys Ala Asn Met Phe Arg Ser Gln Val Xaa Gly Lys Ile 
            20                  25                  30          


Asn Leu Leu Gly Leu Ile Glu Met Ile Leu Leu Ser Val Gly Val Val 
        35                  40                  45              


Met Phe Val Ala Phe Met Ile Ser Tyr Cys Ala Cys Arg Ser Lys Xaa 
    50                  55                  60                  


Ile Lys 
65      


<210> 5438
<211> 27
<212> PRT
<213> Homo sapiens

<400> 5438
Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu Lys Glu Leu Arg 
1               5                   10                  15      


Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu 
            20                  25          


<210> 5439
<211> 213
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<400> 5439
Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu Lys Glu Leu Arg 
1               5                   10                  15      


Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu Leu Phe Ala Xaa 
            20                  25                  30          


Gln Ile Xaa Leu Gly Ile Leu Ile Ser Xaa Gln Arg Ala Gln Leu Glu 
        35                  40                  45              


Arg Ser Leu Arg Asp Val Val Glu Lys Xaa Ile Gln Lys Tyr Gly Xaa 
    50                  55                  60                  


Asn Pro Glu Glu Xaa Ala Ala Glu Glu Ser Trp Asp Tyr Val Gln Phe 
65                  70                  75                  80  


Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp Trp Phe Gln Val 
                85                  90                  95      


Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg Val Pro Cys Ser 
            100                 105                 110         


Cys Tyr Asn Leu Ser Ala Xaa Asn Asp Ser Xaa Ile Leu Asp Lys Val 
        115                 120                 125             


Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala Arg Ser Arg His 
    130                 135                 140                 


Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His Ile Tyr Arg Glu 
145                 150                 155                 160 


Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn Asn Leu Ile Ser 
                165                 170                 175     


Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu Leu Gly Phe Met 
            180                 185                 190         


Xaa Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His Val Tyr Asn Arg 
        195                 200                 205             


Leu Ala Arg Tyr Arg 
    210             


<210> 5440
<211> 202
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<400> 5440
Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu Lys Glu Leu Arg 
1               5                   10                  15      


Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu Leu Phe Ala Xaa 
            20                  25                  30          


Gln Ile Xaa Leu Gly Ile Leu Ile Ser Xaa Gln Arg Ala Gln Leu Glu 
        35                  40                  45              


Arg Ser Leu Arg Asp Val Val Glu Lys Xaa Ile Gln Lys Tyr Gly Xaa 
    50                  55                  60                  


Asn Pro Glu Glu Xaa Ala Ala Glu Glu Ser Trp Asp Tyr Val Gln Phe 
65                  70                  75                  80  


Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp Trp Phe Gln Val 
                85                  90                  95      


Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg Val Pro Cys Ser 
            100                 105                 110         


Cys Tyr Asn Leu Ser Ala Xaa Asn Asp Ser Xaa Ile Leu Asp Lys Val 
        115                 120                 125             


Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala Arg Ser Arg His 
    130                 135                 140                 


Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His Ile Tyr Arg Glu 
145                 150                 155                 160 


Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn Asn Leu Ile Ser 
                165                 170                 175     


Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu Val Ile Trp Pro 
            180                 185                 190         


Arg Pro His Pro Arg Ser Ala Leu Asn Pro 
        195                 200         


<210> 5441
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<400> 5441
Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Xaa Ser Phe Val Ser Phe Ala Trp 
        35                  40                  45              


Pro Ser Cys Leu Cys Arg Ser Gly Pro Lys Ser Trp Pro Ser Gln Glu 
    50                  55                  60                  


Ser Ser Pro Trp Ala Ser Pro Ser Trp Val Val Trp Gly Pro Ser Arg 
65                  70                  75                  80  


Ser Ser Ala Ala Ser Trp Ala Cys Ile Leu Gly Cys Cys Cys Ser Cys 
                85                  90                  95      


Leu Pro His Arg Ser Pro Trp Glu Ser Ser Ser Pro Leu Ser Gly Pro 
            100                 105                 110         


Ser Trp Ser Glu Ala Cys Gly Xaa Ser 
        115                 120     


<210> 5442
<211> 156
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<400> 5442
Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Xaa Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Xaa Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Xaa Gln Ile Xaa Leu Gly Ile Leu Ile Ser Xaa Gln Arg 
            100                 105                 110         


Ala Gln Lys Asp Xaa Pro Xaa Trp Xaa Lys Gly Asp Arg His Lys Gln 
        115                 120                 125             


Leu Gln Arg Glu Xaa His Gly Lys Lys Arg Glu Gln Glu Lys Glu Ile 
    130                 135                 140                 


Asp Ala Leu Lys Glu Glu Xaa Glu Xaa Tyr Glu Pro 
145                 150                 155     


<210> 5443
<211> 270
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<400> 5443
Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Xaa Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Xaa Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Xaa Gln Ile Xaa Leu Gly Ile Leu Ile Ser Xaa Gln Arg 
            100                 105                 110         


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Xaa Ile Gln 
        115                 120                 125             


Lys Tyr Gly Xaa Asn Pro Glu Glu Xaa Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
145                 150                 155                 160 


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Xaa Asn Asp Ser Xaa Ile 
            180                 185                 190         


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
        195                 200                 205             


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Val Ile Trp Pro Arg Pro His Pro Arg Ser Ala Leu Asn Pro 
            260                 265                 270 


<210> 5444
<211> 281
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<400> 5444
Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Xaa Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Xaa Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Xaa Gln Ile Xaa Leu Gly Ile Leu Ile Ser Xaa Gln Arg 
            100                 105                 110         


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Xaa Ile Gln 
        115                 120                 125             


Lys Tyr Gly Xaa Asn Pro Glu Glu Xaa Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
145                 150                 155                 160 


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Xaa Asn Asp Ser Xaa Ile 
            180                 185                 190         


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
        195                 200                 205             


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Xaa Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asn Arg Leu Ala Arg Tyr Arg 
        275                 280     


<210> 5445
<211> 161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<400> 5445
Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Xaa Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Arg Leu Gln Ala Pro Ile His Cys Ser Pro Glu Ala Ser Trp Ser Leu 
    50                  55                  60                  


Ser Leu Leu Pro Ala Asn Gly Val Val His Xaa Asn Asn Asn Asp His 
65                  70                  75                  80  


Glu Ser His Phe Ser Ser Xaa Ser Tyr Leu Ser Gly Leu Val Ala Gly 
                85                  90                  95      


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
            100                 105                 110         


Gly Ile Phe Xaa Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
        115                 120                 125             


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
    130                 135                 140                 


Leu Phe Ala Xaa Gln Ile Xaa Leu Gly Ile Leu Ile Ser Xaa Gln Arg 
145                 150                 155                 160 


Ala 
    


<210> 5446
<211> 254
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<400> 5446
Xaa Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Xaa Ile 
1               5                   10                  15      


Gln Lys Tyr Gly Xaa Asn Pro Glu Glu Xaa Ala Ala Glu Glu Ser Trp 
            20                  25                  30          


Asp Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln 
        35                  40                  45              


Asp Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His 
    50                  55                  60                  


Arg Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Xaa Asn Asp Ser Xaa 
65                  70                  75                  80  


Ile Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu 
                85                  90                  95      


Ala Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser 
            100                 105                 110         


His Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His 
        115                 120                 125             


Asn Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu 
    130                 135                 140                 


Glu Met Xaa Val Met Val Leu Ser Val Gln Leu Gln Arg Arg Ala Leu 
145                 150                 155                 160 


Arg Arg Lys Cys Glu Pro His Val Pro Gly Ala Gly Asp Ser Ser Pro 
                165                 170                 175     


Gly Pro Ser Leu Ile Ala Asp Gly Gly Gly Gly His Ser Gly Ser Leu 
            180                 185                 190         


Trp Gly Gly Trp Gly Met Ala Gly Ala Cys Pro Asn Trp Gly Asp Lys 
        195                 200                 205             


Ala Pro Gln Gly Lys Leu Pro Met Ala Leu Gly Leu Trp Pro Leu Trp 
    210                 215                 220                 


Val Gln Asp Glu Asp Gln Pro Asp Xaa Gly Ser Ala Gly Ala Glu Leu 
225                 230                 235                 240 


Glu Glu Ala Gln Leu Glu Ala Glu Ala Glu Gly Glu Asp Arg 
                245                 250                 


<210> 5447
<211> 300
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<400> 5447
Met Ala Asn Cys Glu Phe Ser Pro Val Ser Gly Asp Lys Pro Cys Cys 
1               5                   10                  15      


Arg Leu Ser Arg Arg Ala Gln Leu Cys Leu Gly Val Ser Ile Leu Val 
            20                  25                  30          


Leu Ile Leu Val Val Val Leu Ala Val Val Val Pro Arg Trp Arg Gln 
        35                  40                  45              


Gln Trp Ser Gly Pro Gly Xaa Xaa Lys Arg Phe Pro Glu Xaa Val Leu 
    50                  55                  60                  


Ala Arg Cys Val Lys Tyr Xaa Glu Ile His Pro Glu Met Arg His Val 
65                  70                  75                  80  


Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys 
                85                  90                  95      


His Pro Cys Asn Ile Xaa Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu 
            100                 105                 110         


Gly Xaa Gln Xaa Val Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile 
        115                 120                 125             


Lys Asp Leu Ala His Gln Phe Xaa Gln Val Gln Arg Asp Met Phe Xaa 
    130                 135                 140                 


Leu Glu Asp Xaa Leu Leu Gly Tyr Leu Ala Asp Asp Leu Xaa Trp Cys 
145                 150                 155                 160 


Gly Glu Phe Asn Xaa Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp 
                165                 170                 175     


Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Xaa Val 
            180                 185                 190         


Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu 
        195                 200                 205             


Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Xaa Phe Gly Ser 
    210                 215                 220                 


Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Xaa Leu Glu Ala 
225                 230                 235                 240 


Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp 
                245                 250                 255     


Pro Xaa Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln 
            260                 265                 270         


Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val 
        275                 280                 285             


Lys Asn Pro Glu Asp Ser Ser Cys Xaa Ser Glu Ile 
    290                 295                 300 


<210> 5448
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 5448
Met Ala Asn Cys Glu Phe Ser Pro Val Ser Gly Asp Lys Pro Cys Cys 
1               5                   10                  15      


Arg Leu Ser Arg Arg Ala Gln Leu Cys Leu Gly Val Ser Ile Leu Val 
            20                  25                  30          


Leu Ile Leu Val Val Val Leu Ala Val Val Val Pro Arg Trp Arg Gln 
        35                  40                  45              


Gln Trp Ser Gly Pro Gly Xaa Xaa Lys Arg Phe Pro Glu Xaa Val Leu 
    50                  55                  60                  


Ala Arg Cys Val Lys Tyr Xaa Glu Ile His Pro Glu Met Arg His Val 
65                  70                  75                  80  


Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys 
                85                  90                  95      


His Pro Cys Asn Ile Xaa Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu 
            100                 105                 110         


Gly Xaa Gln Xaa Val Pro Cys Asn Lys Lys 
        115                 120         


<210> 5449
<211> 152
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<400> 5449
Gln Pro Leu Met Lys Leu Gly Xaa Gln Xaa Val Pro Cys Asn Lys Ile 
1               5                   10                  15      


Leu Leu Trp Ser Arg Ile Lys Asp Leu Ala His Gln Phe Xaa Gln Val 
            20                  25                  30          


Gln Arg Asp Met Phe Xaa Leu Glu Asp Xaa Leu Leu Gly Tyr Leu Ala 
        35                  40                  45              


Asp Asp Leu Xaa Trp Cys Glu Ile Asn Tyr Gln Ser Cys Pro Asp Trp 
    50                  55                  60                  


Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Xaa Val 
65                  70                  75                  80  


Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu 
                85                  90                  95      


Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Xaa Phe Gly Ser 
            100                 105                 110         


Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Xaa Leu Glu Ala 
        115                 120                 125             


Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp 
    130                 135                 140                 


Pro Xaa Ile Lys Glu Leu Glu Ser 
145                 150         


<210> 5450
<211> 98
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 5450
Met Glu His Ser Xaa Phe Leu Ser Gly Leu Val Leu Ala Xaa Leu Leu 
1               5                   10                  15      


Ser Gln Val Cys Gln Ser Cys Val Glu Leu Asp Pro Ala Xaa Val Ala 
            20                  25                  30          


Gly Ile Ile Val Xaa Asp Val Ile Ala Xaa Leu Leu Leu Ala Leu Gly 
        35                  40                  45              


Val Phe Cys Phe Ala Gly His Glu Xaa Gly Arg Leu Ser Gly Ala Ala 
    50                  55                  60                  


Asp Xaa Gln Ala Leu Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg 
65                  70                  75                  80  


Asp Arg Asp Asp Ala Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg 
                85                  90                  95      


Asn Lys 
        


<210> 5451
<211> 171
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<400> 5451
Met Glu His Ser Xaa Phe Leu Ser Gly Leu Val Leu Ala Xaa Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Xaa Ser Ile Xaa Trp Val Glu Gly Xaa Val 
        35                  40                  45              


Gly Xaa Leu Leu Ser Asp Ile Xaa Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Xaa Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Xaa Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Xaa Val Ala Gly Ile Ile Val Xaa Asp Val 
            100                 105                 110         


Ile Ala Xaa Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Xaa Gly Arg Leu Ser Gly Ala Ala Asp Xaa Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210> 5452
<211> 127
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 5452
Met Glu His Ser Xaa Phe Leu Ser Gly Leu Val Leu Ala Xaa Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Xaa Ser Ile Xaa Trp Val Glu Gly Xaa Val 
        35                  40                  45              


Gly Xaa Leu Leu Ser Asp Ile Xaa Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Xaa Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Xaa Val Gln Val His Tyr Arg Xaa Ala Asp Xaa Gln 
                85                  90                  95      


Ala Leu Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp 
            100                 105                 110         


Asp Ala Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        115                 120                 125         


<210> 5453
<211> 132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<400> 5453
Xaa Ser Arg Cys Phe Ser Gly Pro Cys Ser Pro Tyr Ser Ser Ser Val 
1               5                   10                  15      


Val Trp Ile His Phe Gln Glu Val Ser Pro Phe Lys Ile Pro Ile Glu 
            20                  25                  30          


Glu Leu Glu Asp Arg Val Phe Val Asn Cys Asn Xaa Ser Ile Xaa Trp 
        35                  40                  45              


Val Glu Gly Xaa Val Gly Xaa Leu Leu Ser Asp Ile Xaa Arg Leu Asp 
    50                  55                  60                  


Leu Gly Lys Arg Ile Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly 
65                  70                  75                  80  


Xaa Asp Ile Tyr Lys Asp Lys Glu Ser Xaa Val Gln Val His Tyr Arg 
                85                  90                  95      


Xaa Ala Asp Xaa Gln Ala Leu Leu Arg Asn Asp Gln Val Tyr Gln Pro 
            100                 105                 110         


Leu Arg Asp Arg Asp Asp Ala Gln Tyr Ser His Leu Gly Gly Asn Trp 
        115                 120                 125             


Ala Arg Asn Lys 
    130         


<210> 5454
<211> 201
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<400> 5454
Met Gln Ser Gly Xaa His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Ala Tyr Lys Val 
            20                  25                  30          


Ser Ile Ser Gly Xaa Xaa Val Ile Leu Xaa Cys Pro Gln Tyr Pro Gly 
        35                  40                  45              


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
    50                  55                  60                  


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
65                  70                  75                  80  


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
                85                  90                  95      


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
            100                 105                 110         


Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Xaa Ile Val 
        115                 120                 125             


Ile Val Asp Ile Cys Ile Xaa Gly Gly Leu Leu Leu Leu Val Tyr Tyr 
    130                 135                 140                 


Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Xaa Arg Gly Ala 
145                 150                 155                 160 


Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro 
                165                 170                 175     


Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu 
            180                 185                 190         


Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200     


<210> 5455
<211> 207
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<400> 5455
Met Gln Ser Gly Xaa His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Xaa 
            20                  25                  30          


Gln Xaa Pro Tyr Lys Val Ser Ile Ser Gly Xaa Xaa Val Ile Leu Xaa 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Xaa Ile Val Ile Val Asp Ile Cys Ile Xaa Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Xaa Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210> 5456
<211> 510
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<400> 5456
Met Glu Glu Pro Gln Ala Gly Asp Ala Ala Arg Phe Ser Cys Pro Pro 
1               5                   10                  15      


Asn Phe Xaa Ala Lys Pro Pro Ala Ser Glu Ser Pro Arg Phe Ser Leu 
            20                  25                  30          


Glu Ala Leu Xaa Gly Pro Asp Xaa Glu Leu Trp Leu Ile Gln Ala Pro 
        35                  40                  45              


Ala Asp Phe Ala Pro Glu Cys Phe Asn Gly Arg His Val Pro Leu Ser 
    50                  55                  60                  


Gly Ser Gln Ile Val Lys Gly Lys Leu Ala Gly Lys Arg His Arg Tyr 
65                  70                  75                  80  


Arg Val Leu Ser Ser Cys Pro Gln Ala Gly Glu Ala Xaa Leu Leu Ala 
                85                  90                  95      


Pro Ser Xaa Glu Ala Gly Gly Gly Leu Xaa Cys Ala Ser Ala Pro Gln 
            100                 105                 110         


Gly Xaa Leu Arg Ile Leu Glu Gly Pro Gln Gln Ser Leu Ser Gly Ser 
        115                 120                 125             


Pro Leu Gln Pro Ile Pro Ala Ser Pro Pro Pro Gln Ile Pro Pro Gly 
    130                 135                 140                 


Leu Arg Pro Arg Phe Cys Ala Phe Gly Gly Asn Pro Pro Val Xaa Gly 
145                 150                 155                 160 


Pro Arg Ser Ala Leu Ala Pro Asn Leu Leu Xaa Ser Gly Lys Lys Lys 
                165                 170                 175     


Lys Glu Met Gln Val Xaa Glu Ala Pro Val Xaa Gln Glu Ala Val Asn 
            180                 185                 190         


Gly His Gly Ala Leu Glu Val Asp Met Ala Leu Gly Ser Pro Glu Met 
        195                 200                 205             


Asp Val Arg Lys Lys Lys Lys Lys Lys Asn Gln Gln Leu Lys Glu Pro 
    210                 215                 220                 


Glu Ala Ala Gly Pro Val Gly Xaa Glu Pro Xaa Val Glu Xaa Leu Glu 
225                 230                 235                 240 


Pro Leu Gly Val Leu Phe Pro Ser Xaa Xaa Lys Lys Arg Lys Lys Pro 
                245                 250                 255     


Lys Gly Lys Glu Xaa Phe Glu Pro Glu Asp Lys Xaa Val Lys Gln Glu 
            260                 265                 270         


Gln Ile Asn Xaa Glu Pro Leu Glu Asp Xaa Val Leu Ser Pro Xaa Lys 
        275                 280                 285             


Lys Arg Lys Arg Gln Lys Gly Xaa Glu Gly Met Glu Pro Glu Glu Gly 
    290                 295                 300                 


Val Xaa Val Glu Ser Gln Pro Gln Val Lys Val Glu Pro Leu Glu Glu 
305                 310                 315                 320 


Ala Ile Pro Leu Pro Pro Xaa Lys Lys Arg Lys Lys Glu Lys Gly Gln 
                325                 330                 335     


Met Ala Met Met Glu Pro Gly Xaa Glu Ala Met Glu Pro Val Glu Pro 
            340                 345                 350         


Glu Met Lys Pro Leu Glu Ser Pro Gly Gly Xaa Met Ala Pro Gln Gln 
        355                 360                 365             


Pro Glu Gly Ala Lys Pro Gln Ala Gln Ala Ala Leu Ala Ala Pro Lys 
    370                 375                 380                 


Lys Lys Xaa Lys Lys Glu Lys Gln Gln Asp Ala Xaa Val Glu Pro Glu 
385                 390                 395                 400 


Xaa Glu Val Val Gly Pro Glu Leu Pro Asp Asp Leu Glu Pro Gln Ala 
                405                 410                 415     


Ala Pro Xaa Ser Xaa Lys Lys Lys Lys Lys Lys Lys Glu Arg Gly His 
            420                 425                 430         


Xaa Val Xaa Glu Pro Ile Gln Pro Leu Glu Pro Glu Leu Pro Gly Glu 
        435                 440                 445             


Gly Gln Pro Glu Ala Arg Ala Xaa Pro Gly Ser Xaa Lys Lys Arg Lys 
    450                 455                 460                 


Lys Gln Ser Gln Glu Ser Arg Met Pro Glu Xaa Val Pro Gln Glu Glu 
465                 470                 475                 480 


Met Pro Gly Pro Pro Leu Asn Ser Glu Ser Gly Glu Glu Ala Pro Xaa 
                485                 490                 495     


Gly Arg Asp Lys Lys Arg Lys Gln Gln Gln Gln Gln Pro Val 
            500                 505                 510 


<210> 5457
<211> 512
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<400> 5457
Met Glu Glu Pro Gln Ala Gly Gly Glu Asp Ala Ala Arg Phe Ser Cys 
1               5                   10                  15      


Pro Pro Asn Phe Xaa Ala Lys Pro Pro Ala Ser Glu Ser Pro Arg Phe 
            20                  25                  30          


Ser Leu Glu Ala Leu Xaa Gly Pro Asp Xaa Glu Leu Trp Leu Ile Gln 
        35                  40                  45              


Ala Pro Ala Asp Phe Ala Pro Glu Cys Phe Asn Gly Arg His Val Pro 
    50                  55                  60                  


Leu Ser Gly Ser Gln Ile Val Lys Gly Lys Leu Ala Gly Lys Arg His 
65                  70                  75                  80  


Arg Tyr Arg Val Leu Ser Ser Cys Pro Gln Ala Gly Glu Ala Xaa Leu 
                85                  90                  95      


Leu Ala Pro Ser Xaa Glu Ala Gly Gly Gly Leu Xaa Cys Ala Ser Ala 
            100                 105                 110         


Pro Gln Gly Xaa Leu Arg Ile Leu Glu Gly Pro Gln Gln Ser Leu Ser 
        115                 120                 125             


Gly Ser Pro Leu Gln Pro Ile Pro Ala Ser Pro Pro Pro Gln Ile Pro 
    130                 135                 140                 


Pro Gly Leu Arg Pro Arg Phe Cys Ala Phe Gly Gly Asn Pro Pro Val 
145                 150                 155                 160 


Xaa Gly Pro Arg Ser Ala Leu Ala Pro Asn Leu Leu Xaa Ser Gly Lys 
                165                 170                 175     


Lys Lys Lys Glu Met Gln Val Xaa Glu Ala Pro Val Xaa Gln Glu Ala 
            180                 185                 190         


Val Asn Gly His Gly Ala Leu Glu Val Asp Met Ala Leu Gly Ser Pro 
        195                 200                 205             


Glu Met Asp Val Arg Lys Lys Lys Lys Lys Lys Asn Gln Gln Leu Lys 
    210                 215                 220                 


Glu Pro Glu Ala Ala Gly Pro Val Gly Xaa Glu Pro Xaa Val Glu Xaa 
225                 230                 235                 240 


Leu Glu Pro Leu Gly Val Leu Phe Pro Ser Xaa Xaa Lys Lys Arg Lys 
                245                 250                 255     


Lys Pro Lys Gly Lys Glu Xaa Phe Glu Pro Glu Asp Lys Xaa Val Lys 
            260                 265                 270         


Gln Glu Gln Ile Asn Xaa Glu Pro Leu Glu Asp Xaa Val Leu Ser Pro 
        275                 280                 285             


Xaa Lys Lys Arg Lys Arg Gln Lys Gly Xaa Glu Gly Met Glu Pro Glu 
    290                 295                 300                 


Glu Gly Val Xaa Val Glu Ser Gln Pro Gln Val Lys Val Glu Pro Leu 
305                 310                 315                 320 


Glu Glu Ala Ile Pro Leu Pro Pro Xaa Lys Lys Arg Lys Lys Glu Lys 
                325                 330                 335     


Gly Gln Met Ala Met Met Glu Pro Gly Xaa Glu Ala Met Glu Pro Val 
            340                 345                 350         


Glu Pro Glu Met Lys Pro Leu Glu Ser Pro Gly Gly Xaa Met Ala Pro 
        355                 360                 365             


Gln Gln Pro Glu Gly Ala Lys Pro Gln Ala Gln Ala Ala Leu Ala Ala 
    370                 375                 380                 


Pro Lys Lys Lys Xaa Lys Lys Glu Lys Gln Gln Asp Ala Xaa Val Glu 
385                 390                 395                 400 


Pro Glu Xaa Glu Val Val Gly Pro Glu Leu Pro Asp Asp Leu Glu Pro 
                405                 410                 415     


Gln Ala Ala Pro Xaa Ser Xaa Lys Lys Lys Lys Lys Lys Lys Glu Arg 
            420                 425                 430         


Gly His Xaa Val Xaa Glu Pro Ile Gln Pro Leu Glu Pro Glu Leu Pro 
        435                 440                 445             


Gly Glu Gly Gln Pro Glu Ala Arg Ala Xaa Pro Gly Ser Xaa Lys Lys 
    450                 455                 460                 


Arg Lys Lys Gln Ser Gln Glu Ser Arg Met Pro Glu Xaa Val Pro Gln 
465                 470                 475                 480 


Glu Glu Met Pro Gly Pro Pro Leu Asn Ser Glu Ser Gly Glu Glu Ala 
                485                 490                 495     


Pro Xaa Gly Arg Asp Lys Lys Arg Lys Gln Gln Gln Gln Gln Pro Val 
            500                 505                 510         


<210> 5458
<211> 39
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<400> 5458
Met Gln Val Xaa Glu Ala Pro Val Xaa Gln Glu Ala Val Asn Gly His 
1               5                   10                  15      


Gly Ala Leu Glu Val Asp Met Ala Leu Gly Ser Pro Glu Met Asp Val 
            20                  25                  30          


Arg Lys Lys Lys Lys Lys Lys 
        35                  


<210> 5459
<211> 67
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<400> 5459
Xaa Glu Glu Pro Gln Ala Gly Ala Ser Met Gly Gly Met Cys Leu Ser 
1               5                   10                  15      


Leu Ala Pro Arg Ser Ser Arg Ala Asn Trp Gln Ala Ser Gly Xaa Ala 
            20                  25                  30          


Ile Glu Ser Ser Ala Ala Val Pro Lys Leu Glu Lys Arg Pro Cys Trp 
        35                  40                  45              


Pro Pro Gln Arg Arg Gln Glu Val Asp Ser Pro Val Pro Gln Pro Pro 
    50                  55                  60                  


Arg Ala Pro 
65          


<210> 5460
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<400> 5460
Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Xaa Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Xaa Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Xaa Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Xaa Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Xaa Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Xaa Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210> 5461
<211> 40
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<400> 5461
Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Xaa Leu Ala Gln Ser Ile Lys Gly Arg Arg Asn Gly Phe 
            20                  25                  30          


Phe Leu Tyr Ser Asp Ser Glu Tyr 
        35                  40  


<210> 5462
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<400> 5462
Met Ile Gly Phe Leu Xaa Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser 
1               5                   10                  15      


Asn Ala Lys Asp Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn 
            20                  25                  30          


Lys Ser Lys Pro Leu Gln Val Tyr Tyr Arg Xaa Ser Asp Lys Gln Xaa 
        35                  40                  45              


Leu Leu Pro Asn Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp 
    50                  55                  60                  


Asp Gln Tyr Ser His Leu Gln Gly Asn Gln Leu Arg Arg Asn 
65                  70                  75              


<210> 5463
<211> 45
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<400> 5463
Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Xaa Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Xaa Val Glu Leu Xaa Cys Xaa Ala Ser Gln 
        35                  40                  45  


<210> 5464
<211> 458
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<400> 5464
Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Xaa Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Xaa Val Glu Leu Xaa Cys Xaa Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Xaa Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Xaa Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Xaa Ala Asn 
        115                 120                 125             


Ser Asp Xaa His Leu Leu Gln Gly Gln Ser Leu Xaa Leu Xaa Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Xaa Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Xaa Trp Xaa Cys Xaa Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 
        195                 200                 205             


Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 
    210                 215                 220                 


Leu Ala Phe Xaa Val Glu Lys Leu Xaa Gly Ser Gly Glu Leu Trp Trp 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Xaa Phe Asp Leu 
                245                 250                 255     


Lys Asn Lys Glu Val Ser Val Lys Arg Val Xaa Gln Asp Pro Lys Leu 
            260                 265                 270         


Gln Met Gly Lys Lys Leu Pro Leu His Leu Xaa Leu Pro Gln Ala Leu 
        275                 280                 285             


Pro Gln Tyr Ala Gly Ser Gly Asn Leu Xaa Leu Ala Leu Glu Ala Lys 
    290                 295                 300                 


Xaa Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Xaa 
305                 310                 315                 320 


Gln Leu Gln Lys Asn Leu Xaa Cys Glu Val Trp Gly Pro Xaa Ser Pro 
                325                 330                 335     


Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 
            340                 345                 350         


Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
    370                 375                 380                 


Lys Val Leu Pro Xaa Trp Ser Xaa Pro Val Gln Pro Met Ala Leu Ile 
385                 390                 395                 400 


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
                405                 410                 415     


Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met 
            420                 425                 430         


Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Xaa Cys Gln Cys Pro 
        435                 440                 445             


His Arg Phe Gln Lys Xaa Cys Ser Pro Ile 
    450                 455             


<210> 5465
<211> 148
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 5465
Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Gly Pro Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp 
            20                  25                  30          


Asp Gln Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp 
        35                  40                  45              


Ser Asp Xaa Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln 
    50                  55                  60                  


Leu Leu Val Phe Gly Leu Xaa Ala Asn Ser Asp Xaa His Leu Leu Gln 
65                  70                  75                  80  


Gly Gln Ser Leu Xaa Leu Xaa Leu Glu Ser Pro Pro Gly Ser Ser Pro 
                85                  90                  95      


Ser Val Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys 
            100                 105                 110         


Xaa Leu Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Xaa Trp Xaa 
        115                 120                 125             


Cys Xaa Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp Ile 
    130                 135                 140                 


Val Val Leu Gly 
145             


<210> 5466
<211> 203
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 5466
Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Xaa 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Xaa Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Xaa Glu Phe Xaa Glu Xaa Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Xaa Trp Asn Arg Glu Xaa His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Xaa 
                85                  90                  95      


Ser Glu Xaa Asp Xaa Ile Cys Xaa Cys Glu Glu Gly Trp His Cys Xaa 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Xaa Gly Val Ser Asp Xaa Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Xaa Arg Ser Pro Gly Ser Ala Glu Ser Pro Gly Gly 
                165                 170                 175     


Asp Pro His His Leu Arg Asp Pro Val Cys His Pro Leu Gly Ala Gly 
            180                 185                 190         


Leu Tyr Gln Lys Gly Gly Gln Glu Ala Asn Gln 
        195                 200             


<210> 5467
<211> 277
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<400> 5467
Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Xaa 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Xaa Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Xaa Glu Phe Xaa Glu Xaa Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Xaa Trp Asn Arg Glu Xaa His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Xaa 
                85                  90                  95      


Ser Glu Xaa Asp Xaa Ile Cys Xaa Cys Glu Glu Gly Trp His Cys Xaa 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Xaa Gly Val Ser Asp Xaa Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Xaa Ser Cys Glu Xaa Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Xaa Asn Lys Xaa Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Xaa Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Xaa Ala Ala Pro Val Gln Glu Xaa Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Xaa Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210> 5468
<211> 151
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<400> 5468
Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Xaa 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Xaa Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Xaa Glu Phe Xaa Glu Xaa Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Xaa Trp Asn Arg Glu Xaa His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Xaa 
                85                  90                  95      


Ser Glu Xaa Asp Xaa Ile Cys Xaa Cys Glu Glu Gly Trp His Cys Xaa 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Asp Ile Cys Gln Pro His Phe Pro Lys Asp 
    130                 135                 140                 


Arg Gly Leu Asn Leu Leu Met 
145                 150     


<210> 5469
<211> 159
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 5469
Xaa Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Xaa Ala 
1               5                   10                  15      


Val His Pro Glu Pro Pro Xaa Ala Cys Arg Glu Lys Gln Tyr Leu Ile 
            20                  25                  30          


Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val Ser 
        35                  40                  45              


Asp Cys Xaa Glu Phe Xaa Glu Xaa Glu Cys Leu Pro Cys Gly Glu Ser 
    50                  55                  60                  


Glu Phe Leu Asp Xaa Trp Asn Arg Glu Xaa His Cys His Gln His Lys 
65                  70                  75                  80  


Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Xaa Ser 
                85                  90                  95      


Glu Xaa Asp Xaa Ile Cys Xaa Cys Glu Glu Gly Trp His Cys Xaa Ser 
            100                 105                 110         


Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly Phe 
        115                 120                 125             


Gly Val Lys Gln Ile Ala Val Arg Pro Lys Xaa Trp Leu Cys Asn Arg 
    130                 135                 140                 


Gln Ala Gln Xaa Arg Leu Met Leu Ser Val Val Pro Arg Ile Gly 
145                 150                 155                 


<210> 5470
<211> 261
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<400> 5470
Met Ile Glu Xaa Tyr Asn Gln Xaa Ser Pro Arg Ser Ala Ala Xaa Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Xaa Val Phe Leu 
            20                  25                  30          


Ile Xaa Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Xaa Ile Gln Arg Cys Asn Xaa Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Xaa Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Xaa Xaa Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Xaa Met Ser Asn Asn Leu Val Xaa Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Xaa Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Xaa 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Xaa His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Xaa Asp Pro Ser Gln Val Ser His Gly Xaa Gly Phe Xaa Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210> 5471
<211> 240
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<400> 5471
Met Ile Glu Xaa Tyr Asn Gln Xaa Ser Pro Arg Ser Ala Ala Xaa Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Xaa Val Phe Leu 
            20                  25                  30          


Ile Xaa Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Xaa Ile Gln Arg Cys Asn Xaa Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Xaa Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Val Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Xaa Met Ser 
        115                 120                 125             


Asn Asn Leu Val Xaa Leu Glu Asn Gly Lys Gln Leu Xaa Val Lys Arg 
    130                 135                 140                 


Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Xaa Phe Cys Ser Asn Arg 
145                 150                 155                 160 


Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser 
                165                 170                 175     


Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala Ala Asn Xaa His Ser 
            180                 185                 190         


Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe 
        195                 200                 205             


Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn Val Xaa Asp Pro Ser 
    210                 215                 220                 


Gln Val Ser His Gly Xaa Gly Phe Xaa Ser Phe Gly Leu Leu Lys Leu 
225                 230                 235                 240 


<210> 5472
<211> 240
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<400> 5472
Asp Leu Asn Ile Xaa Cys Arg Phe Ala Gly Val Phe His Val Glu Lys 
1               5                   10                  15      


Asn Gly Arg Tyr Ser Ile Ser Arg Xaa Glu Ala Ala Asp Leu Cys Lys 
            20                  25                  30          


Ala Phe Asn Ser Xaa Leu Pro Xaa Met Ala Gln Met Glu Lys Ala Leu 
        35                  40                  45              


Ser Ile Gly Phe Glu Xaa Cys Arg Tyr Gly Phe Ile Glu Gly His Val 
    50                  55                  60                  


Val Ile Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Xaa 
65                  70                  75                  80  


Gly Val Tyr Ile Leu Xaa Ser Asn Xaa Ser Gln Tyr Asp Xaa Tyr Cys 
                85                  90                  95      


Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Xaa Ser Val Xaa Asp 
            100                 105                 110         


Leu Pro Asn Ala Phe Asp Gly Pro Ile Xaa Ile Xaa Ile Val Asn Arg 
        115                 120                 125             


Asp Gly Xaa Arg Tyr Val Gln Lys Gly Glu Tyr Arg Xaa Asn Pro Glu 
    130                 135                 140                 


Asp Ile Tyr Pro Ser Asn Pro Xaa Asp Asp Asp Val Ser Ser Gly Ser 
145                 150                 155                 160 


Ser Ser Glu Arg Ser Ser Xaa Ser Gly Asp Arg Asn Asp Val Xaa Gly 
                165                 170                 175     


Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Xaa Xaa Leu Leu Glu 
            180                 185                 190         


Gly Tyr Xaa Ser His Tyr Pro His Xaa Lys Glu Ser Arg Xaa Phe Ile 
        195                 200                 205             


Pro Val Xaa Ser Ala Lys Xaa Gly Ser Phe Gly Val Xaa Ala Val Xaa 
    210                 215                 220                 


Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln 
225                 230                 235                 240 


<210> 5473
<211> 249
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<400> 5473
Glu Asp Cys Xaa Ser Val Xaa Asp Leu Pro Asn Ala Phe Asp Gly Pro 
1               5                   10                  15      


Ile Xaa Ile Xaa Ile Val Asn Arg Asp Gly Xaa Arg Tyr Val Gln Lys 
            20                  25                  30          


Gly Glu Tyr Arg Xaa Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Xaa 
        35                  40                  45              


Asp Asp Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Xaa Ser 
    50                  55                  60                  


Gly Gly Tyr Ile Phe Tyr Xaa Phe Ser Xaa Val His Pro Ile Pro Asp 
65                  70                  75                  80  


Glu Asp Ser Pro Trp Ile Xaa Asp Ser Xaa Asp Arg Ile Pro Ala Xaa 
                85                  90                  95      


Ile Gln Ala Xaa Pro Ser Ser Xaa Xaa Glu Glu Xaa Ala Xaa Gln Lys 
            100                 105                 110         


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Xaa Pro 
        115                 120                 125             


Lys Glu Asp Ser His Ser Xaa Xaa Gly Xaa Ala Ala Ala Ser Ala His 
    130                 135                 140                 


Xaa Ser His Pro Met Gln Gly Arg Xaa Xaa Pro Ser Pro Glu Asp Ser 
145                 150                 155                 160 


Ser Trp Xaa Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
                165                 170                 175     


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Xaa 
            180                 185                 190         


Leu Gln Pro Xaa Ala Asn Pro Asn Xaa Gly Leu Val Glu Asp Leu Asp 
        195                 200                 205             


Arg Xaa Gly Pro Leu Ser Met Xaa Xaa Gln Gln Ser Asn Ser Gln Ser 
    210                 215                 220                 


Phe Ser Xaa Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Xaa 
225                 230                 235                 240 


Xaa Ser Xaa Leu Xaa Ser Ser Ser Lys 
                245                 


<210> 5474
<211> 249
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<400> 5474
Ile Asp Leu Asn Ile Xaa Cys Arg Phe Ala Gly Val Phe His Val Glu 
1               5                   10                  15      


Lys Asn Gly Arg Tyr Ser Ile Ser Arg Xaa Glu Ala Ala Asp Leu Cys 
            20                  25                  30          


Lys Ala Phe Asn Ser Xaa Leu Pro Xaa Met Ala Gln Met Glu Lys Ala 
        35                  40                  45              


Leu Ser Ile Gly Phe Glu Xaa Cys Arg Tyr Gly Phe Ile Glu Gly His 
    50                  55                  60                  


Val Val Ile Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn 
65                  70                  75                  80  


Xaa Gly Val Tyr Ile Leu Xaa Ser Asn Xaa Ser Gln Tyr Asp Xaa Tyr 
                85                  90                  95      


Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Xaa Ser Val Xaa 
            100                 105                 110         


Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Xaa Ile Xaa Ile Val Asn 
        115                 120                 125             


Arg Asp Gly Xaa Arg Tyr Val Gln Lys Gly Glu Tyr Arg Xaa Asn Pro 
    130                 135                 140                 


Glu Asp Ile Tyr Pro Ser Asn Pro Xaa Asp Asp Asp Val Ser Ser Gly 
145                 150                 155                 160 


Ser Ser Ser Glu Arg Ser Ser Xaa Ser Gly Gly Tyr Ile Phe Tyr Xaa 
                165                 170                 175     


Phe Ser Xaa Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile Xaa 
            180                 185                 190         


Asp Ser Xaa Asp Arg Ile Pro Ala Xaa Xaa Ala Ser Ala His Xaa Ser 
        195                 200                 205             


His Pro Met Gln Gly Arg Xaa Xaa Pro Ser Pro Glu Asp Ser Ser Trp 
    210                 215                 220                 


Xaa Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly His Gln 
225                 230                 235                 240 


Ala Gly Arg Arg Met Gly Asn Ser Leu 
                245                 


<210> 5475
<211> 193
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<400> 5475
Ile Tyr Pro Ser Asn Pro Xaa Asp Asp Asp Val Ser Ser Gly Ser Ser 
1               5                   10                  15      


Ser Glu Arg Ser Ser Xaa Ser Gly Gly Tyr Ile Phe Tyr Xaa Phe Ser 
            20                  25                  30          


Xaa Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile Xaa Asp Ser 
        35                  40                  45              


Xaa Asp Arg Ile Pro Ala Xaa Ser Xaa Ser Ser Asn Xaa Ile Ser Ala 
    50                  55                  60                  


Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg His Leu 
65                  70                  75                  80  


Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile Ser Ser 
                85                  90                  95      


Xaa Asn Met Asp Ser Ser His Ser Ile Xaa Leu Gln Pro Xaa Ala Asn 
            100                 105                 110         


Pro Asn Xaa Gly Leu Val Glu Asp Leu Asp Arg Xaa Gly Pro Leu Ser 
        115                 120                 125             


Met Xaa Xaa Gln Gln Ser Asn Ser Gln Ser Phe Ser Xaa Ser His Glu 
    130                 135                 140                 


Gly Leu Glu Glu Asp Lys Asp His Pro Xaa Xaa Ser Xaa Leu Xaa Ser 
145                 150                 155                 160 


Ser Asn Arg Asn Asp Val Xaa Gly Gly Arg Arg Asp Pro Asn His Ser 
                165                 170                 175     


Glu Gly Ser Xaa Xaa Leu Leu Glu Gly Tyr Xaa Ser His Tyr Pro His 
            180                 185                 190         


Xaa 
    


<210> 5476
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<400> 5476
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Xaa Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Xaa Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Xaa Leu Pro Xaa Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Xaa Cys Arg 
65                  70                  75              


<210> 5477
<211> 493
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<400> 5477
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Xaa Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Xaa Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Xaa Leu Pro Xaa Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Xaa Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Xaa Gly Val Tyr Ile Leu Xaa Ser Asn Xaa Ser 
            100                 105                 110         


Gln Tyr Asp Xaa Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Xaa Ser Val Xaa Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Xaa 
    130                 135                 140                 


Ile Xaa Ile Val Asn Arg Asp Gly Xaa Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Xaa Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Xaa Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Xaa Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Xaa Phe Ser Xaa Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Xaa Asp Ser Xaa Asp Arg Ile Pro Ala Xaa Asn Met 
    210                 215                 220                 


Asp Ser Ser His Ser Ile Xaa Leu Gln Pro Xaa Ala Asn Pro Asn Xaa 
225                 230                 235                 240 


Gly Leu Val Glu Asp Leu Asp Arg Xaa Gly Pro Leu Ser Met Xaa Xaa 
                245                 250                 255     


Gln Gln Ser Asn Ser Gln Ser Phe Ser Xaa Ser His Glu Gly Leu Glu 
            260                 265                 270         


Glu Asp Lys Asp His Pro Xaa Xaa Ser Xaa Leu Xaa Ser Ser Asn Arg 
        275                 280                 285             


Asn Asp Val Xaa Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser 
    290                 295                 300                 


Xaa Xaa Leu Leu Glu Gly Tyr Xaa Ser His Tyr Pro His Xaa Lys Glu 
305                 310                 315                 320 


Ser Arg Xaa Phe Ile Pro Val Xaa Ser Ala Lys Xaa Gly Ser Phe Gly 
                325                 330                 335     


Val Xaa Ala Val Xaa Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser 
            340                 345                 350         


Leu Ser Gly Asp Gln Asp Xaa Phe His Pro Ser Gly Gly Ser His Xaa 
        355                 360                 365             


Xaa His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly 
    370                 375                 380                 


Gly Ala Asn Xaa Xaa Ser Gly Pro Ile Arg Xaa Pro Gln Ile Pro Glu 
385                 390                 395                 400 


Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala 
                405                 410                 415     


Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys 
            420                 425                 430         


Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser 
        435                 440                 445             


Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val 
    450                 455                 460                 


Asn Lys Glu Ser Ser Glu Xaa Pro Asp Gln Phe Met Xaa Ala Asp Glu 
465                 470                 475                 480 


Xaa Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
                485                 490             


<210> 5478
<211> 429
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<400> 5478
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Xaa Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Xaa Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Xaa Leu Pro Xaa Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Xaa Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Xaa Gly Val Tyr Ile Leu Xaa Ser Asn Xaa Ser 
            100                 105                 110         


Gln Tyr Asp Xaa Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Xaa Ser Val Xaa Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Xaa 
    130                 135                 140                 


Ile Xaa Ile Val Asn Arg Asp Gly Xaa Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Xaa Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Xaa Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Xaa Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Xaa Phe Ser Xaa Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Xaa Asp Ser Xaa Asp Arg Ile Pro Ala Xaa Asn Arg 
    210                 215                 220                 


Asn Asp Val Xaa Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser 
225                 230                 235                 240 


Xaa Xaa Leu Leu Glu Gly Tyr Xaa Ser His Tyr Pro His Xaa Lys Glu 
                245                 250                 255     


Ser Arg Xaa Phe Ile Pro Val Xaa Ser Ala Lys Xaa Gly Ser Phe Gly 
            260                 265                 270         


Val Xaa Ala Val Xaa Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser 
        275                 280                 285             


Leu Ser Gly Asp Gln Asp Xaa Phe His Pro Ser Gly Gly Ser His Xaa 
    290                 295                 300                 


Xaa His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly 
305                 310                 315                 320 


Gly Ala Asn Xaa Xaa Ser Gly Pro Ile Arg Xaa Pro Gln Ile Pro Glu 
                325                 330                 335     


Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala 
            340                 345                 350         


Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys 
        355                 360                 365             


Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser 
    370                 375                 380                 


Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val 
385                 390                 395                 400 


Asn Lys Glu Ser Ser Glu Xaa Pro Asp Gln Phe Met Xaa Ala Asp Glu 
                405                 410                 415     


Xaa Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
            420                 425                 


<210> 5479
<211> 361
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<400> 5479
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Xaa Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Xaa Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Xaa Leu Pro Xaa Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Xaa Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Xaa Gly Val Tyr Ile Leu Xaa Ser Asn Xaa Ser 
            100                 105                 110         


Gln Tyr Asp Xaa Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Xaa Ser Val Xaa Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Xaa 
    130                 135                 140                 


Ile Xaa Ile Val Asn Arg Asp Gly Xaa Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Xaa Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Xaa Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Xaa Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Xaa Phe Ser Xaa Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Xaa Asp Ser Xaa Asp Arg Ile Pro Ala Xaa Arg Asp 
    210                 215                 220                 


Gln Asp Xaa Phe His Pro Ser Gly Gly Ser His Xaa Xaa His Gly Ser 
225                 230                 235                 240 


Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Xaa 
                245                 250                 255     


Xaa Ser Gly Pro Ile Arg Xaa Pro Gln Ile Pro Glu Trp Leu Ile Ile 
            260                 265                 270         


Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala 
        275                 280                 285             


Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn 
    290                 295                 300                 


Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly 
305                 310                 315                 320 


Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser 
                325                 330                 335     


Ser Glu Xaa Pro Asp Gln Phe Met Xaa Ala Asp Glu Xaa Arg Asn Leu 
            340                 345                 350         


Gln Asn Val Asp Met Lys Ile Gly Val 
        355                 360     


<210> 5480
<211> 340
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<400> 5480
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Xaa Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Xaa Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Xaa Leu Pro Xaa Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Xaa Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Xaa Gly Val Tyr Ile Leu Xaa Ser Asn Xaa Ser 
            100                 105                 110         


Gln Tyr Asp Xaa Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Xaa Ser Val Xaa Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Xaa 
    130                 135                 140                 


Ile Xaa Ile Val Asn Arg Asp Gly Xaa Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Xaa Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Xaa Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Xaa Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Xaa Phe Ser Xaa Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Xaa Asp Ser Xaa Asp Arg Ile Pro Ala Xaa Arg His 
    210                 215                 220                 


Ser His Gly Ser Gln Glu Gly Gly Ala Asn Xaa Xaa Ser Gly Pro Ile 
225                 230                 235                 240 


Arg Xaa Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu 
                245                 250                 255     


Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg 
            260                 265                 270         


Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala 
        275                 280                 285             


Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser 
    290                 295                 300                 


Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Xaa Pro Asp 
305                 310                 315                 320 


Gln Phe Met Xaa Ala Asp Glu Xaa Arg Asn Leu Gln Asn Val Asp Met 
                325                 330                 335     


Lys Ile Gly Val 
            340 


<210> 5481
<211> 699
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<400> 5481
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Xaa Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Xaa Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Xaa Leu Pro Xaa Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Xaa Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Xaa Gly Val Tyr Ile Leu Xaa Ser Asn Xaa Ser 
            100                 105                 110         


Gln Tyr Asp Xaa Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Xaa Ser Val Xaa Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Xaa 
    130                 135                 140                 


Ile Xaa Ile Val Asn Arg Asp Gly Xaa Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Xaa Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Xaa Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Xaa Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Xaa Phe Ser Xaa Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Xaa Asp Ser Xaa Asp Arg Ile Pro Ala Xaa Ser Xaa 
    210                 215                 220                 


Ser Ser Asn Xaa Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu 
225                 230                 235                 240 


Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp 
                245                 250                 255     


Asp Glu Asp Phe Ile Ser Ser Xaa Ile Ser Xaa Xaa Pro Arg Ala Phe 
            260                 265                 270         


Asp His Xaa Lys Gln Asn Gln Asp Trp Xaa Gln Trp Asn Pro Ser His 
        275                 280                 285             


Ser Asn Pro Glu Val Leu Leu Gln Xaa Xaa Xaa Arg Met Xaa Asp Val 
    290                 295                 300                 


Asp Arg Asn Gly Xaa Xaa Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala 
305                 310                 315                 320 


His Pro Pro Leu Ile His His Glu His His Glu Glu Glu Glu Xaa Pro 
                325                 330                 335     


His Ser Xaa Ser Xaa Ile Gln Ala Xaa Pro Ser Ser Xaa Xaa Glu Glu 
            340                 345                 350         


Xaa Ala Xaa Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly 
        355                 360                 365             


Tyr Arg Gln Xaa Pro Lys Glu Asp Ser His Ser Xaa Xaa Gly Xaa Ala 
    370                 375                 380                 


Ala Ala Ser Ala His Xaa Ser His Pro Met Gln Gly Arg Xaa Xaa Pro 
385                 390                 395                 400 


Ser Pro Glu Asp Ser Ser Trp Xaa Asp Phe Phe Asn Pro Ile Ser His 
                405                 410                 415     


Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp Ser 
            420                 425                 430         


Ser His Ser Ile Xaa Leu Gln Pro Xaa Ala Asn Pro Asn Xaa Gly Leu 
        435                 440                 445             


Val Glu Asp Leu Asp Arg Xaa Gly Pro Leu Ser Met Xaa Xaa Gln Gln 
    450                 455                 460                 


Ser Asn Ser Gln Ser Phe Ser Xaa Ser His Glu Gly Leu Glu Glu Asp 
465                 470                 475                 480 


Lys Asp His Pro Xaa Xaa Ser Xaa Leu Xaa Ser Ser Asn Arg Asn Asp 
                485                 490                 495     


Val Xaa Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Xaa Xaa 
            500                 505                 510         


Leu Leu Glu Gly Tyr Xaa Ser His Tyr Pro His Xaa Lys Glu Ser Arg 
        515                 520                 525             


Xaa Phe Ile Pro Val Xaa Ser Ala Lys Xaa Gly Ser Phe Gly Val Xaa 
    530                 535                 540                 


Ala Val Xaa Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser 
545                 550                 555                 560 


Gly Asp Gln Asp Xaa Phe His Pro Ser Gly Gly Ser His Xaa Xaa His 
                565                 570                 575     


Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala 
            580                 585                 590         


Asn Xaa Xaa Ser Gly Pro Ile Arg Xaa Pro Gln Ile Pro Glu Trp Leu 
        595                 600                 605             


Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys 
    610                 615                 620                 


Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val 
625                 630                 635                 640 


Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu 
                645                 650                 655     


Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys 
            660                 665                 670         


Glu Ser Ser Glu Xaa Pro Asp Gln Phe Met Xaa Ala Asp Glu Xaa Arg 
        675                 680                 685             


Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
    690                 695                 


<210> 5482
<211> 742
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<400> 5482
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Xaa Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Xaa Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Xaa Leu Pro Xaa Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Xaa Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Xaa Gly Val Tyr Ile Leu Xaa Ser Asn Xaa Ser 
            100                 105                 110         


Gln Tyr Asp Xaa Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Xaa Ser Val Xaa Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Xaa 
    130                 135                 140                 


Ile Xaa Ile Val Asn Arg Asp Gly Xaa Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Xaa Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Xaa Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Xaa Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Xaa Phe Ser Xaa Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Xaa Asp Ser Xaa Asp Arg Ile Pro Ala Xaa Xaa Leu 
    210                 215                 220                 


Met Ser Xaa Ser Ala Xaa Ala Xaa Glu Xaa Ala Xaa Lys Arg Gln Glu 
225                 230                 235                 240 


Xaa Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Xaa Xaa Xaa Gln Met Ala Gly Xaa Ser Ser Asn Xaa Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Xaa Ile Ser Xaa Xaa Pro Arg Ala Phe Asp His Xaa Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Xaa Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Xaa Xaa Xaa Arg Met Xaa Asp Val Asp Arg Asn Gly Xaa 
            340                 345                 350         


Xaa Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Xaa Pro His Ser Xaa Ser Xaa 
    370                 375                 380                 


Ile Gln Ala Xaa Pro Ser Ser Xaa Xaa Glu Glu Xaa Ala Xaa Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Xaa Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Xaa Xaa Gly Xaa Ala Ala Ala Ser Ala His 
            420                 425                 430         


Xaa Ser His Pro Met Gln Gly Arg Xaa Xaa Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Xaa Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Xaa 
465                 470                 475                 480 


Leu Gln Pro Xaa Ala Asn Pro Asn Xaa Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Xaa Gly Pro Leu Ser Met Xaa Xaa Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Xaa Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Xaa 
        515                 520                 525             


Xaa Ser Xaa Leu Xaa Ser Ser Asn Arg Asn Asp Val Xaa Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Xaa Xaa Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Xaa Ser His Tyr Pro His Xaa Lys Glu Ser Arg Xaa Phe Ile Pro Val 
                565                 570                 575     


Xaa Ser Ala Lys Xaa Gly Ser Phe Gly Val Xaa Ala Val Xaa Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Xaa 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Xaa Xaa His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Xaa Xaa Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Xaa Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Xaa 
705                 710                 715                 720 


Pro Asp Gln Phe Met Xaa Ala Asp Glu Xaa Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210> 5483
<211> 206
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<400> 5483
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Xaa Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Xaa Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Xaa Leu Pro Xaa Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Xaa Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Gly Ala Asn Xaa Xaa Ser Gly Pro Ile Arg Xaa Pro Gln Ile Pro 
            100                 105                 110         


Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu 
        115                 120                 125             


Ala Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys 
    130                 135                 140                 


Lys Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro 
145                 150                 155                 160 


Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu 
                165                 170                 175     


Val Asn Lys Glu Ser Ser Glu Xaa Pro Asp Gln Phe Met Xaa Ala Asp 
            180                 185                 190         


Glu Xaa Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
        195                 200                 205     


<210> 5484
<211> 139
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 5484
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Xaa Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Xaa Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Xaa Leu Pro Xaa Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Xaa Cys Ser Leu His 
65                  70                  75                  80  


Cys Ser Gln Gln Ser Lys Lys Val Trp Ala Glu Glu Lys Ala Ser Asp 
                85                  90                  95      


Gln Gln Trp Gln Trp Ser Cys Gly Gly Gln Lys Ala Lys Trp Xaa Gln 
            100                 105                 110         


Arg Arg Gly Gln Gln Val Ser Gly Asn Gly Ala Phe Gly Glu Gln Gly 
        115                 120                 125             


Val Val Arg Asn Ser Arg Pro Val Tyr Asp Ser 
    130                 135                 


<210> 5485
<211> 80
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 5485
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Xaa Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Xaa Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Xaa Leu Pro Xaa Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Xaa Cys Ser Ser Xaa 
65                  70                  75                  80  


<210> 5486
<211> 232
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<400> 5486
Pro Glu Asp Ile Tyr Pro Ser Asn Pro Xaa Asp Asp Asp Val Ser Ser 
1               5                   10                  15      


Gly Ser Ser Ser Glu Arg Ser Ser Xaa Ser Gly Gly Tyr Ile Phe Tyr 
            20                  25                  30          


Xaa Phe Ser Xaa Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile 
        35                  40                  45              


Xaa Asp Ser Xaa Asp Arg Ile Pro Ala Xaa Asn Met Asp Ser Ser His 
    50                  55                  60                  


Ser Ile Xaa Leu Gln Pro Xaa Ala Asn Pro Asn Xaa Gly Leu Val Glu 
65                  70                  75                  80  


Asp Leu Asp Arg Xaa Gly Pro Leu Ser Met Xaa Xaa Gln Gln Ser Asn 
                85                  90                  95      


Ser Gln Ser Phe Ser Xaa Ser His Glu Gly Leu Glu Glu Asp Lys Asp 
            100                 105                 110         


His Pro Xaa Xaa Ser Xaa Leu Xaa Ser Ser Arg Asp Gln Asp Xaa Phe 
        115                 120                 125             


His Pro Ser Gly Gly Ser His Xaa Xaa His Gly Ser Glu Ser Asp Gly 
    130                 135                 140                 


His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Xaa Xaa Ser Gly Pro 
145                 150                 155                 160 


Ile Arg Xaa Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu 
                165                 170                 175     


Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg 
            180                 185                 190         


Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly 
        195                 200                 205             


Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys 
    210                 215                 220                 


Ser Gln Glu Met Val His Leu Val 
225                 230         


<210> 5487
<211> 195
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<400> 5487
Arg Asn Gly Xaa Xaa Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His 
1               5                   10                  15      


Pro Pro Leu Ile His His Glu His His Glu Glu Glu Glu Xaa Pro His 
            20                  25                  30          


Ser Xaa Ser Xaa Ile Gln Ala Xaa Pro Ser Ser Xaa Xaa Glu Glu Xaa 
        35                  40                  45              


Ala Xaa Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr 
    50                  55                  60                  


Arg Gln Xaa Pro Lys Glu Asp Ser His Ser Xaa Xaa Gly Xaa Ala Asp 
65                  70                  75                  80  


Met Asp Ser Ser His Ser Ile Xaa Leu Gln Pro Xaa Ala Asn Pro Asn 
                85                  90                  95      


Xaa Gly Leu Val Glu Asp Leu Asp Arg Xaa Gly Pro Leu Ser Met Xaa 
            100                 105                 110         


Xaa Gln Gln Ser Asn Ser Gln Ser Phe Ser Xaa Ser His Glu Gly Leu 
        115                 120                 125             


Glu Glu Asp Lys Asp His Pro Xaa Xaa Ser Xaa Leu Xaa Ser Ser Asn 
    130                 135                 140                 


Arg Asn Asp Val Xaa Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly 
145                 150                 155                 160 


Ser Xaa Xaa Leu Leu Glu Gly Tyr Xaa Ser His Tyr Pro His Xaa Lys 
                165                 170                 175     


Glu Ser Arg Xaa Phe Ile Pro Val Xaa Ser Ala Lys Xaa Gly Ser Phe 
            180                 185                 190         


Gly Val Xaa 
        195 


<210> 5488
<211> 187
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<400> 5488
Arg Xaa Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Xaa Asp Asp Asp 
1               5                   10                  15      


Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Xaa Ser Gly Gly Tyr 
            20                  25                  30          


Ile Phe Tyr Xaa Phe Ser Xaa Val His Pro Ile Pro Asp Glu Asp Ser 
        35                  40                  45              


Pro Trp Ile Xaa Asp Ser Xaa Asp Arg Ile Pro Ala Xaa Ser Xaa Ser 
    50                  55                  60                  


Ser Asn Xaa Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp 
65                  70                  75                  80  


Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp 
                85                  90                  95      


Glu Asp Phe Ile Ser Ser Xaa Arg Asp Gln Asp Xaa Phe His Pro Ser 
            100                 105                 110         


Gly Gly Ser His Xaa Xaa His Gly Ser Glu Ser Asp Gly His Ser His 
        115                 120                 125             


Gly Ser Gln Glu Gly Gly Ala Asn Xaa Xaa Ser Gly Pro Ile Arg Xaa 
    130                 135                 140                 


Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu 
145                 150                 155                 160 


Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys 
                165                 170                 175     


Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly 
            180                 185         


<210> 5489
<211> 287
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<400> 5489
Arg Tyr Ser Ile Ser Arg Xaa Glu Ala Ala Asp Leu Cys Lys Ala Phe 
1               5                   10                  15      


Asn Ser Xaa Leu Pro Xaa Met Ala Gln Met Glu Lys Ala Leu Ser Ile 
            20                  25                  30          


Gly Phe Glu Xaa Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val Ile 
        35                  40                  45              


Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Xaa Gly Val 
    50                  55                  60                  


Tyr Ile Leu Xaa Ser Asn Xaa Ser Gln Tyr Asp Xaa Tyr Cys Phe Asn 
65                  70                  75                  80  


Ala Ser Ala Pro Pro Glu Glu Asp Cys Xaa Ser Val Xaa Asp Leu Pro 
                85                  90                  95      


Asn Ala Phe Asp Gly Pro Ile Xaa Ile Xaa Ile Val Asn Arg Asp Gly 
            100                 105                 110         


Xaa Arg Tyr Val Gln Lys Gly Glu Tyr Arg Xaa Asn Pro Glu Asp Ile 
        115                 120                 125             


Tyr Pro Ser Asn Pro Xaa Asp Asp Asp Val Ser Ser Gly Ser Ser Ser 
    130                 135                 140                 


Glu Arg Ser Ser Xaa Ser Gly Gly Asp Gln Asp Xaa Phe His Pro Ser 
145                 150                 155                 160 


Gly Gly Ser His Xaa Xaa His Gly Ser Glu Ser Asp Gly His Ser His 
                165                 170                 175     


Gly Ser Gln Glu Gly Gly Ala Asn Xaa Xaa Ser Gly Pro Ile Arg Xaa 
            180                 185                 190         


Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu 
        195                 200                 205             


Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys 
    210                 215                 220                 


Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu 
225                 230                 235                 240 


Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu 
                245                 250                 255     


Met Val His Leu Val Asn Lys Glu Ser Ser Glu Xaa Pro Asp Gln Phe 
            260                 265                 270         


Met Xaa Ala Asp Glu Xaa Arg Asn Leu Gln Asn Val Asp Met Lys 
        275                 280                 285         


<210> 5490
<211> 82
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<400> 5490
Ser Lys His Asn Leu Trp Ser Tyr Lys Asp Xaa Pro Asn Ser Arg Cys 
1               5                   10                  15      


Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu 
            20                  25                  30          


Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu 
        35                  40                  45              


Met Val His Leu Val Asn Lys Glu Ser Ser Glu Xaa Pro Asp Gln Phe 
    50                  55                  60                  


Met Xaa Ala Asp Glu Xaa Arg Asn Leu Gln Asn Val Asp Met Lys Ile 
65                  70                  75                  80  


Gly Val 
        


<210> 5491
<211> 294
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<400> 5491
Xaa Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Xaa Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Xaa Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Xaa Leu Pro Xaa Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Xaa Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Xaa Gly Val Tyr Ile Leu Xaa Ser Asn Xaa Ser 
            100                 105                 110         


Gln Tyr Asp Xaa Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Xaa Ser Val Xaa Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Xaa 
    130                 135                 140                 


Ile Xaa Ile Val Asn Arg Asp Gly Xaa Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Xaa Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Xaa Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Xaa Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Xaa Phe Ser Xaa Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Xaa Asp Ser Xaa Asp Arg Ile Pro Ala Xaa Arg Asp 
    210                 215                 220                 


Gln Asp Xaa Phe His Pro Ser Gly Gly Ser His Xaa Xaa His Gly Ser 
225                 230                 235                 240 


Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Xaa 
                245                 250                 255     


Xaa Ser Gly Pro Ile Arg Xaa Pro Gln Ile Pro Glu Trp Leu Ile Ile 
            260                 265                 270         


Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala 
        275                 280                 285             


Val Asn Ser Arg Arg Ser 
    290                 


<210> 5492
<211> 243
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<400> 5492
Xaa Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Xaa Ile Xaa Ile Val 
1               5                   10                  15      


Asn Arg Asp Gly Xaa Arg Tyr Val Gln Lys Gly Glu Tyr Arg Xaa Asn 
            20                  25                  30          


Pro Glu Asp Ile Tyr Pro Ser Asn Pro Xaa Asp Asp Asp Val Ser Ser 
        35                  40                  45              


Gly Ser Ser Ser Glu Arg Ser Ser Xaa Ser Gly Gly Tyr Ile Phe Tyr 
    50                  55                  60                  


Xaa Phe Ser Xaa Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile 
65                  70                  75                  80  


Xaa Asp Ser Xaa Asp Arg Ile Pro Ala Xaa Xaa Leu Met Ser Xaa Ser 
                85                  90                  95      


Ala Xaa Ala Xaa Glu Xaa Ala Xaa Lys Arg Gln Glu Xaa Trp Asp Trp 
            100                 105                 110         


Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn His Leu His Xaa 
        115                 120                 125             


Xaa Xaa Gln Met Ala Gly Xaa Ser Ser Asn Xaa Ile Ser Ala Gly Trp 
    130                 135                 140                 


Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg His Leu Ser Phe 
145                 150                 155                 160 


Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile Ser Ser Xaa Asn 
                165                 170                 175     


Met Asp Ser Ser His Ser Ile Xaa Leu Gln Pro Xaa Ala Asn Pro Asn 
            180                 185                 190         


Xaa Gly Leu Val Glu Asp Leu Asp Arg Xaa Gly Pro Leu Ser Met Xaa 
        195                 200                 205             


Xaa Gln Gln Ser Asn Ser Gln Ser Phe Ser Xaa Ser His Glu Gly Leu 
    210                 215                 220                 


Glu Glu Asp Lys Asp His Pro Xaa Xaa Ser Xaa Leu Xaa Ser Ser Ser 
225                 230                 235                 240 


Lys Asp Tyr 
            


<210> 5493
<211> 195
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<400> 5493
Xaa Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser 
1               5                   10                  15      


Ile Cys Ala Ala Asn Asn Xaa Gly Val Tyr Ile Leu Xaa Ser Asn Xaa 
            20                  25                  30          


Ser Gln Tyr Asp Xaa Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu 
        35                  40                  45              


Asp Cys Xaa Ser Val Xaa Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile 
    50                  55                  60                  


Xaa Ile Xaa Ile Val Asn Arg Asp Gly Xaa Arg Tyr Val Gln Lys Gly 
65                  70                  75                  80  


Glu Tyr Arg Xaa Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Xaa Asp 
                85                  90                  95      


Asp Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Xaa Ser Gly 
            100                 105                 110         


Gly Tyr Ile Phe Tyr Xaa Phe Ser Xaa Val His Pro Ile Pro Asp Glu 
        115                 120                 125             


Asp Ser Pro Trp Ile Xaa Asp Ser Xaa Asp Arg Ile Pro Ala Xaa Lys 
    130                 135                 140                 


Gln Ser Asn Ser Gln Ser Phe Ser Xaa Ser His Glu Gly Leu Glu Glu 
145                 150                 155                 160 


Asp Lys Asp His Pro Xaa Xaa Ser Xaa Leu Xaa Ser Ser Asn Arg Asn 
                165                 170                 175     


Asp Val Xaa Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Xaa 
            180                 185                 190         


Xaa Leu Leu 
        195 


<210> 5494
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(98)
<223> Selenocysteine

<400> 5494
Xaa Pro Asp Glu Asp Ser Pro Trp Ile Xaa Asp Ser Xaa Asp Arg Ile 
1               5                   10                  15      


Pro Ala Xaa Ser Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp 
            20                  25                  30          


Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe 
        35                  40                  45              


Ile Ser Ser Xaa Ile Ser Xaa Xaa Pro Arg Ala Phe Asp His Xaa Lys 
    50                  55                  60                  


Gln Asn Gln Asp Trp Xaa Gln Trp Asn Pro Ser His Ser Asn Pro Glu 
65                  70                  75                  80  


Val Leu Leu Gln Xaa Xaa Xaa Arg Met Xaa Asp Val Asp Arg Asn Gly 
                85                  90                  95      


Xaa Xaa Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu 
            100                 105                 110         


Ile His His Glu His His 
        115             


<210> 5495
<211> 230
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<400> 5495
Xaa Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Xaa Cys Arg Tyr 
1               5                   10                  15      


Gly Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser 
            20                  25                  30          


Ile Cys Ala Ala Asn Asn Xaa Gly Val Tyr Ile Leu Xaa Ser Asn Xaa 
        35                  40                  45              


Ser Gln Tyr Asp Xaa Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu 
    50                  55                  60                  


Asp Cys Xaa Ser Val Xaa Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile 
65                  70                  75                  80  


Xaa Ile Xaa Ile Val Asn Arg Asp Gly Xaa Arg Tyr Val Gln Lys Gly 
                85                  90                  95      


Glu Tyr Arg Xaa Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Xaa Asp 
            100                 105                 110         


Asp Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Xaa Ser Gly 
        115                 120                 125             


Gly Tyr Ile Phe Tyr Xaa Phe Ser Xaa Val His Pro Ile Pro Asp Glu 
    130                 135                 140                 


Asp Ser Pro Trp Ile Xaa Asp Ser Xaa Asp Arg Ile Pro Ala Xaa Ile 
145                 150                 155                 160 


Ser Xaa Xaa Pro Arg Ala Phe Asp His Xaa Lys Gln Asn Gln Asp Trp 
                165                 170                 175     


Xaa Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val Leu Leu Gln Xaa 
            180                 185                 190         


Xaa Xaa Arg Met Xaa Asp Val Asp Arg Asn Gly Xaa Xaa Ala Tyr Glu 
        195                 200                 205             


Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile His His Glu His 
    210                 215                 220                 


His Glu Glu Glu Glu Xaa 
225                 230 


<210> 5496
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(181)
<223> Selenocysteine

<400> 5496
Xaa Arg Xaa Glu Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Xaa Leu 
1               5                   10                  15      


Pro Xaa Met Ala Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Xaa 
            20                  25                  30          


Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His 
        35                  40                  45              


Pro Asn Ser Ile Cys Ala Ala Asn Asn Xaa Gly Val Tyr Ile Leu Xaa 
    50                  55                  60                  


Ser Asn Xaa Ser Gln Tyr Asp Xaa Tyr Cys Phe Asn Ala Ser Ala Pro 
65                  70                  75                  80  


Pro Glu Glu Asp Cys Xaa Ser Val Xaa Asp Leu Pro Asn Ala Phe Asp 
                85                  90                  95      


Gly Pro Ile Xaa Ile Xaa Ile Val Asn Arg Asp Gly Xaa Arg Tyr Val 
            100                 105                 110         


Gln Lys Gly Glu Tyr Arg Xaa Asn Pro Glu Asp Ile Tyr Pro Ser Asn 
        115                 120                 125             


Pro Xaa Asp Asp Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser 
    130                 135                 140                 


Xaa Ser Gly Asp Met Asp Ser Ser His Ser Ile Xaa Leu Gln Pro Xaa 
145                 150                 155                 160 


Ala Asn Pro Asn Xaa Gly Leu Val Glu Asp Leu Asp Arg Xaa Gly Pro 
                165                 170                 175     


Leu Ser Met Xaa Xaa 
            180     


<210> 5497
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<400> 5497
Xaa Ser Xaa Xaa Pro Arg Ala Phe Asp His Xaa Lys Gln Asn Gln Asp 
1               5                   10                  15      


Trp Xaa Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val Leu Leu Gln 
            20                  25                  30          


Xaa Xaa Xaa Arg Met Xaa Val Gln Ala Xaa Pro Ser Ser Xaa Xaa Glu 
        35                  40                  45              


Glu Xaa Ala Xaa Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu 
    50                  55                  60                  


Gly Tyr Arg Gln Xaa Pro Lys Glu Asp Ser His Ser Xaa Xaa Gly Xaa 
65                  70                  75                  80  


Ala Ala Ser Ala His Xaa Ser His Pro Met Gln Gly Arg Xaa Xaa Pro 
                85                  90                  95      


Ser Pro Glu Asp Ser Ser Trp Xaa Asp Phe Phe Asn Pro Ile Ser His 
            100                 105                 110         


Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp Ser 
        115                 120                 125             


Ser His Ser Ile Xaa Leu Gln Pro Xaa Ala Asn Pro Asn Xaa Gly Leu 
    130                 135                 140                 


Val Glu Asp Leu Asp Arg Xaa Gly Pro Leu Ser Met Xaa Xaa Gln Gln 
145                 150                 155                 160 


Ser Asn Ser Gln Ser Phe Ser Xaa Ser His Glu Gly Leu Glu Glu Asp 
                165                 170                 175     


Lys Asp His Pro Xaa Xaa Ser Xaa Leu Xaa Ser Ser Ser Lys Asp 
            180                 185                 190     


<210> 5498
<211> 349
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<400> 5498
Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Xaa Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Xaa His Xaa Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Xaa Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Xaa Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Xaa Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Xaa Pro Pro Pro Lys Ile Lys Asn Gly Lys His Xaa Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Xaa Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Xaa Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Xaa Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Xaa Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Xaa Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Gly Pro Arg 
        275                 280                 285             


Pro Xaa Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro 
    290                 295                 300                 


Glu Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile 
305                 310                 315                 320 


Val Ile Ala Ile Gly Lys Gln Met Val Glu Leu Asn Met Pro Leu Xaa 
                325                 330                 335     


Arg Leu Asn Gln Pro Leu Gln Gln Ser Arg Glu Ala Glu 
            340                 345                 


<210> 5499
<211> 355
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(349)
<223> Selenocysteine

<400> 5499
Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Xaa Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Xaa His Xaa Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Xaa Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Xaa Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Xaa Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Xaa Pro Pro Pro Lys Ile Lys Asn Gly Lys His Xaa Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Xaa Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Xaa Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Xaa Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Xaa Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Xaa Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Gly Tyr Pro 
        275                 280                 285             


Lys Pro Glu Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala 
    290                 295                 300                 


Val Ile Val Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val 
305                 310                 315                 320 


Pro Tyr Arg Tyr Leu Gln Arg Arg Lys Lys Lys Gly Lys Ala Asp Gly 
                325                 330                 335     


Gly Ala Glu Tyr Ala Xaa Tyr Gln Xaa Lys Ser Xaa Xaa Pro Ala Glu 
            340                 345                 350         


Gln Arg Gly 
        355 


<210> 5500
<211> 362
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<400> 5500
Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Xaa Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Xaa His Xaa Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Xaa Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Xaa Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Xaa Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Xaa Pro Pro Pro Lys Ile Lys Asn Gly Lys His Xaa Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Xaa Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Xaa Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Xaa Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Xaa Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Xaa Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Gly Pro Arg 
        275                 280                 285             


Pro Xaa Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro 
    290                 295                 300                 


Glu Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile 
305                 310                 315                 320 


Val Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr 
                325                 330                 335     


Arg Tyr Leu Gln Arg Arg Lys Lys Lys Gly Xaa Tyr Leu Xaa Asp Glu 
            340                 345                 350         


Xaa His Arg Glu Val Lys Phe Xaa Ser Leu 
        355                 360         


<210> 5501
<211> 369
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(363)
<223> Selenocysteine

<400> 5501
Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Xaa Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Xaa His Xaa Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Xaa Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Xaa Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Xaa Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Xaa Pro Pro Pro Lys Ile Lys Asn Gly Lys His Xaa Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Xaa Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Xaa Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Xaa Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Xaa Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Xaa Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Gly Pro Arg 
        275                 280                 285             


Pro Xaa Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro 
    290                 295                 300                 


Glu Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile 
305                 310                 315                 320 


Val Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr 
                325                 330                 335     


Arg Tyr Leu Gln Arg Arg Lys Lys Lys Gly Lys Ala Asp Gly Gly Ala 
            340                 345                 350         


Glu Tyr Ala Xaa Tyr Gln Xaa Lys Ser Xaa Xaa Pro Ala Glu Gln Arg 
        355                 360                 365             


Gly 
    


<210> 5502
<211> 370
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(364)
<223> Selenocysteine

<400> 5502
Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Xaa Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Xaa His Xaa Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Xaa Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Xaa Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Xaa Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Xaa Pro Pro Pro Lys Ile Lys Asn Gly Lys His Xaa Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Xaa Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Xaa Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Xaa Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Xaa Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Xaa Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Ser Xaa 
        275                 280                 285             


Ser Ser Xaa Xaa Lys Ser Pro Ala Ser Ser Ala Ser Gly Tyr Pro Lys 
    290                 295                 300                 


Pro Glu Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val 
305                 310                 315                 320 


Ile Val Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro 
                325                 330                 335     


Tyr Arg Tyr Leu Gln Arg Arg Lys Lys Lys Gly Lys Ala Asp Gly Gly 
            340                 345                 350         


Ala Glu Tyr Ala Xaa Tyr Gln Xaa Lys Ser Xaa Xaa Pro Ala Glu Gln 
        355                 360                 365             


Arg Gly 
    370 


<210> 5503
<211> 377
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<400> 5503
Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Xaa Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Xaa His Xaa Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Xaa Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Xaa Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Xaa Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Xaa Pro Pro Pro Lys Ile Lys Asn Gly Lys His Xaa Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Xaa Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Xaa Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Xaa Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Xaa Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Xaa Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Ser Xaa 
        275                 280                 285             


Ser Ser Xaa Xaa Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro 
    290                 295                 300                 


Xaa Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu 
305                 310                 315                 320 


Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile Val 
                325                 330                 335     


Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr Arg 
            340                 345                 350         


Tyr Leu Gln Arg Arg Lys Lys Lys Gly Xaa Tyr Leu Xaa Asp Glu Xaa 
        355                 360                 365             


His Arg Glu Val Lys Phe Xaa Ser Leu 
    370                 375         


<210> 5504
<211> 384
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(378)
<223> Selenocysteine

<400> 5504
Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Xaa Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Xaa His Xaa Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Xaa Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Xaa Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Xaa Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Xaa Pro Pro Pro Lys Ile Lys Asn Gly Lys His Xaa Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Xaa Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Xaa Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Xaa Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Xaa Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Xaa Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Ser Xaa 
        275                 280                 285             


Ser Ser Xaa Xaa Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro 
    290                 295                 300                 


Xaa Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu 
305                 310                 315                 320 


Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile Val 
                325                 330                 335     


Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr Arg 
            340                 345                 350         


Tyr Leu Gln Arg Arg Lys Lys Lys Gly Lys Ala Asp Gly Gly Ala Glu 
        355                 360                 365             


Tyr Ala Xaa Tyr Gln Xaa Lys Ser Xaa Xaa Pro Ala Glu Gln Arg Gly 
    370                 375                 380                 


<210> 5505
<211> 392
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<400> 5505
Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Xaa Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Xaa His Xaa Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Xaa Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Xaa Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Xaa Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Xaa Pro Pro Pro Lys Ile Lys Asn Gly Lys His Xaa Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Xaa Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Xaa Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Xaa Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Xaa Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Xaa Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Leu Pro 
        275                 280                 285             


Pro Ser Ser Xaa Lys Pro Pro Ala Leu Ser His Ser Val Ser Xaa Ser 
    290                 295                 300                 


Ser Xaa Xaa Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro Xaa 
305                 310                 315                 320 


Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu Glu 
                325                 330                 335     


Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile Val Ile 
            340                 345                 350         


Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr Arg Tyr 
        355                 360                 365             


Leu Gln Arg Arg Lys Lys Lys Gly Xaa Tyr Leu Xaa Asp Glu Xaa His 
    370                 375                 380                 


Arg Glu Val Lys Phe Xaa Ser Leu 
385                 390         


<210> 5506
<211> 399
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(393)
<223> Selenocysteine

<400> 5506
Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Xaa Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Xaa His Xaa Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Xaa Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Xaa Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Xaa Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Xaa Pro Pro Pro Lys Ile Lys Asn Gly Lys His Xaa Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Xaa Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Xaa Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Xaa Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Xaa Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Xaa Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Leu Pro 
        275                 280                 285             


Pro Ser Ser Xaa Lys Pro Pro Ala Leu Ser His Ser Val Ser Xaa Ser 
    290                 295                 300                 


Ser Xaa Xaa Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro Xaa 
305                 310                 315                 320 


Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu Glu 
                325                 330                 335     


Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile Val Ile 
            340                 345                 350         


Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr Arg Tyr 
        355                 360                 365             


Leu Gln Arg Arg Lys Lys Lys Gly Lys Ala Asp Gly Gly Ala Glu Tyr 
    370                 375                 380                 


Ala Xaa Tyr Gln Xaa Lys Ser Xaa Xaa Pro Ala Glu Gln Arg Gly 
385                 390                 395                 


<210> 5507
<211> 336
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(330)
<223> Selenocysteine

<400> 5507
Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Gly Glu Xaa Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val 
        35                  40                  45              


Pro Ala Asn Gly Xaa Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys 
    50                  55                  60                  


Asn Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu 
65                  70                  75                  80  


Lys Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys 
                85                  90                  95      


Val Leu Cys Xaa Pro Pro Pro Lys Ile Lys Asn Gly Lys His Xaa Phe 
            100                 105                 110         


Ser Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Xaa Tyr Ser Cys 
        115                 120                 125             


Asp Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Xaa 
    130                 135                 140                 


Ile Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys 
145                 150                 155                 160 


Lys Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile 
                165                 170                 175     


Ser Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Xaa Val Met Phe Glu 
            180                 185                 190         


Cys Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Xaa Ile Val Cys Asp 
        195                 200                 205             


Ser Asn Ser Xaa Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Leu 
    210                 215                 220                 


Pro Pro Ser Ser Xaa Lys Pro Pro Ala Leu Ser His Ser Val Ser Xaa 
225                 230                 235                 240 


Ser Ser Xaa Xaa Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro 
                245                 250                 255     


Xaa Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu 
            260                 265                 270         


Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile Val 
        275                 280                 285             


Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr Arg 
    290                 295                 300                 


Tyr Leu Gln Arg Arg Lys Lys Lys Gly Lys Ala Asp Gly Gly Ala Glu 
305                 310                 315                 320 


Tyr Ala Xaa Tyr Gln Xaa Lys Ser Xaa Xaa Pro Ala Glu Gln Arg Gly 
                325                 330                 335     


<210> 5508
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(72)
<223> Selenocysteine

<400> 5508
Xaa Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu Glu Gly 
1               5                   10                  15      


Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile Val Ile Ala 
            20                  25                  30          


Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr Arg Tyr Leu 
        35                  40                  45              


Gln Arg Arg Lys Lys Lys Gly Lys Ala Asp Gly Gly Ala Glu Tyr Ala 
    50                  55                  60                  


Xaa Tyr Gln Xaa Lys Ser Xaa Xaa Pro Ala Glu Gln Arg Gly 
65                  70                  75              


<210> 5509
<211> 305
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<400> 5509
Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Xaa Lys Ser Val Glu Phe Xaa Phe 
            20                  25                  30          


Cys Asn Asp Xaa Val Val Ile Pro Cys Phe Val Xaa Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Xaa Xaa Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Xaa Phe Asp Gly Ala Leu Asn Lys Ser Xaa Val Pro Xaa Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Xaa Gly Asn Tyr 
            100                 105                 110         


Xaa Cys Glu Val Xaa Glu Leu Xaa Arg Glu Gly Glu Xaa Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Xaa Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Xaa 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Xaa Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Xaa 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Xaa Ser Xaa Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Xaa Ala Ile Gly Leu Xaa Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Xaa Ile Gln Pro Pro Arg Asn 
    290                 295                 300                 


Asn 
305 


<210> 5510
<211> 323
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<400> 5510
Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Xaa Lys Ser Val Glu Phe Xaa Phe 
            20                  25                  30          


Cys Asn Asp Xaa Val Val Ile Pro Cys Phe Val Xaa Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Xaa Xaa Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Xaa Phe Asp Gly Ala Leu Asn Lys Ser Xaa Val Pro Xaa Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Xaa Gly Asn Tyr 
            100                 105                 110         


Xaa Cys Glu Val Xaa Glu Leu Xaa Arg Glu Gly Glu Xaa Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Xaa Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Xaa 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Xaa Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Xaa 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Xaa Ser Xaa Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Xaa Ala Ile Gly Leu Xaa Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Xaa Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            


<210> 5511
<211> 109
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 5511
Xaa Lys Asn Ala Xaa Gly Leu Gly Leu Ile Val Xaa Ser Xaa Gly Ile 
1               5                   10                  15      


Leu Ile Leu Leu His Tyr Tyr Val Phe Ser Xaa Ala Ile Gly Leu Xaa 
            20                  25                  30          


Ser Phe Val Ile Ala Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu 
        35                  40                  45              


Ala Val Val Gly Leu Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His 
    50                  55                  60                  


Gly Pro Leu Leu Ile Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu 
65                  70                  75                  80  


Leu Gly Leu Val Tyr Met Lys Phe Val Ala Ser Asn Gln Lys Xaa Ile 
                85                  90                  95      


Gln Pro Pro Arg Lys Ala Val Glu Glu Pro Leu Asn Glu 
            100                 105                 


<210> 5512
<211> 86
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<400> 5512
Xaa Trp Xaa Glu Ser Leu Tyr Cys Gly Val Tyr Xaa Asn Ala Trp Pro 
1               5                   10                  15      


Ser Ser Asp Phe Arg Phe Glu Tyr Leu Ser Ser Ser Xaa Ile Xaa Trp 
            20                  25                  30          


Xaa Ser Leu Tyr Glu Ile Cys Gly Val Gln Arg Asp Xaa Tyr Ser Gln 
        35                  40                  45              


Leu Lys Gly Lys Lys Arg Gln Ala Ser Asn Gln Lys Xaa Ile Gln Pro 
    50                  55                  60                  


Pro Arg Lys Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys 
65                  70                  75                  80  


Gly Met Met Asn Asp Glu 
                85      


<210> 5513
<211> 243
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<400> 5513
Met Cys Ser Arg Gly Trp Asp Ser Cys Leu Ala Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Val Xaa Ser Ile Gln Gly His Leu Val His 
            20                  25                  30          


Met Xaa Val Val Ser Gly Ser Asn Val Xaa Leu Asn Ile Ser Glu Ser 
        35                  40                  45              


Leu Pro Glu Asn Tyr Lys Gln Leu Xaa Trp Phe Tyr Xaa Phe Asp Gln 
    50                  55                  60                  


Lys Ile Val Glu Trp Asp Ser Arg Lys Ser Lys Tyr Phe Glu Ser Lys 
65                  70                  75                  80  


Phe Lys Gly Arg Val Arg Leu Asp Pro Gln Ser Gly Ala Leu Tyr Ile 
                85                  90                  95      


Ser Lys Val Gln Lys Glu Asp Asn Ser Xaa Tyr Ile Met Arg Val Leu 
            100                 105                 110         


Lys Lys Xaa Gly Asn Glu Gln Glu Trp Lys Ile Lys Leu Gln Val Leu 
        115                 120                 125             


Asp Pro Val Pro Lys Pro Val Ile Lys Ile Glu Lys Ile Glu Asp Met 
    130                 135                 140                 


Asp Asp Asn Cys Tyr Leu Lys Leu Ser Cys Val Ile Pro Gly Glu Ser 
145                 150                 155                 160 


Val Asn Tyr Xaa Trp Tyr Gly Asp Lys Arg Pro Phe Pro Lys Glu Leu 
                165                 170                 175     


Gln Asn Ser Val Leu Glu Xaa Xaa Leu Met Pro His Asn Tyr Ser Arg 
            180                 185                 190         


Cys Tyr Xaa Cys Gln Val Ser Asn Ser Val Ser Ser Lys Asn Gly Xaa 
        195                 200                 205             


Val Cys Leu Ser Pro Pro Cys Xaa Leu Ala Arg Ser Phe Gly Val Glu 
    210                 215                 220                 


Trp Ile Ala Ser Trp Leu Val Val Xaa Val Pro Xaa Ile Leu Gly Leu 
225                 230                 235                 240 


Leu Leu Xaa 
            


<210> 5514
<211> 252
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<400> 5514
Met Cys Ser Arg Gly Trp Asp Ser Cys Leu Ala Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Val Xaa Ser Ile Gln Gly His Leu Val His 
            20                  25                  30          


Met Xaa Val Val Ser Gly Ser Asn Val Xaa Leu Asn Ile Ser Glu Ser 
        35                  40                  45              


Leu Pro Glu Asn Tyr Lys Gln Leu Xaa Trp Phe Tyr Xaa Phe Asp Gln 
    50                  55                  60                  


Lys Ile Val Glu Trp Asp Ser Arg Lys Ser Lys Tyr Phe Glu Ser Lys 
65                  70                  75                  80  


Phe Lys Gly Arg Val Arg Leu Asp Pro Gln Ser Gly Ala Leu Tyr Ile 
                85                  90                  95      


Ser Lys Val Gln Lys Glu Asp Asn Ser Xaa Tyr Ile Met Arg Val Leu 
            100                 105                 110         


Lys Lys Xaa Gly Asn Glu Gln Glu Trp Lys Ile Lys Leu Gln Val Leu 
        115                 120                 125             


Asp Pro Val Pro Lys Pro Val Ile Lys Ile Glu Lys Ile Glu Asp Met 
    130                 135                 140                 


Asp Asp Asn Cys Tyr Leu Lys Leu Ser Cys Val Ile Pro Gly Glu Ser 
145                 150                 155                 160 


Val Asn Tyr Xaa Trp Tyr Gly Asp Lys Arg Pro Phe Pro Lys Glu Leu 
                165                 170                 175     


Gln Asn Ser Val Leu Glu Xaa Xaa Leu Met Pro His Asn Tyr Ser Arg 
            180                 185                 190         


Cys Tyr Xaa Cys Gln Val Ser Asn Ser Val Ser Ser Lys Asn Gly Xaa 
        195                 200                 205             


Val Cys Leu Ser Pro Pro Cys Xaa Leu Gly Lys Lys Asp Pro Trp Glu 
    210                 215                 220                 


Leu Arg Gly Ala Gln Gly Asn Trp Ser Cys Phe Glu Gln Arg Lys Ala 
225                 230                 235                 240 


Gly Gly Pro Ile Gln Pro Pro Cys Xaa Val Trp Trp 
                245                 250         


<210> 5515
<211> 169
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 5515
Met Cys Ser Arg Gly Trp Asp Ser Cys Leu Ala Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Val Xaa Ser Ile Gln Gly His Leu Val His 
            20                  25                  30          


Met Xaa Val Val Ser Gly Ser Asn Val Xaa Leu Asn Ile Ser Glu Ser 
        35                  40                  45              


Leu Pro Glu Asn Tyr Lys Gln Leu Xaa Trp Phe Tyr Xaa Phe Asp Gln 
    50                  55                  60                  


Lys Ile Val Glu Trp Asp Ser Arg Lys Ser Lys Tyr Phe Glu Ser Lys 
65                  70                  75                  80  


Phe Lys Gly Arg Val Arg Leu Asp Pro Gln Ser Gly Ala Leu Tyr Ile 
                85                  90                  95      


Ser Lys Val Gln Lys Glu Asp Asn Ser Xaa Tyr Ile Met Arg Val Leu 
            100                 105                 110         


Lys Lys Xaa Gly Asn Glu Gln Glu Trp Lys Ile Lys Leu Gln Val Leu 
        115                 120                 125             


Gly Glu Ser Gly Glu Pro Lys Ser Lys Ser Pro Leu Gln Trp Pro Gln 
    130                 135                 140                 


Met Asp His Cys Arg Ala Ser Trp Glu Ala Trp Gly Xaa Leu Gly Glu 
145                 150                 155                 160 


Glu Glu Arg Lys Xaa Ser Gly Gln Val 
                165                 


<210> 5516
<211> 165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<400> 5516
Met Pro Met Gly Ser Leu Gln Pro Leu Ala Xaa Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Cys Leu Gly Arg Leu Ser Trp Tyr Asp Pro Asp 
            20                  25                  30          


Phe Gln Ala Arg Leu Xaa Arg Ser Asn Ser Lys Cys Gln Gly Gln Leu 
        35                  40                  45              


Glu Val Tyr Leu Lys Asp Gly Trp His Met Val Cys Ser Gln Ser Trp 
    50                  55                  60                  


Gly Arg Ser Ser Lys Gln Trp Glu Asp Pro Ser Gln Ala Ser Lys Val 
65                  70                  75                  80  


Cys Gln Arg Leu Asn Cys Gly Val Pro Leu Ser Leu Gly Pro Phe Leu 
                85                  90                  95      


Val Xaa Tyr Xaa Pro Gln Ser Ser Ile Ile Cys Tyr Gly Gln Leu Gly 
            100                 105                 110         


Ser Phe Ser Asn Cys Ser His Ser Arg Asn Asp Met Cys His Ser Leu 
        115                 120                 125             


Gly Leu Xaa Cys Leu Glu Pro Gln Lys Xaa Xaa Pro Pro Xaa Xaa Arg 
    130                 135                 140                 


Pro Pro Pro Xaa Xaa Xaa Pro Glu Pro Xaa Ala Met Arg Pro Arg Xaa 
145                 150                 155                 160 


Arg Pro Arg Xaa Trp 
                165 


<210> 5517
<211> 495
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<400> 5517
Met Pro Met Gly Ser Leu Gln Pro Leu Ala Xaa Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Cys Leu Gly Arg Leu Ser Trp Tyr Asp Pro Asp 
            20                  25                  30          


Phe Gln Ala Arg Leu Xaa Arg Ser Asn Ser Lys Cys Gln Gly Gln Leu 
        35                  40                  45              


Glu Val Tyr Leu Lys Asp Gly Trp His Met Val Cys Ser Gln Ser Trp 
    50                  55                  60                  


Gly Arg Ser Ser Lys Gln Trp Glu Asp Pro Ser Gln Ala Ser Lys Val 
65                  70                  75                  80  


Cys Gln Arg Leu Asn Cys Gly Val Pro Leu Ser Leu Gly Pro Phe Leu 
                85                  90                  95      


Val Xaa Tyr Xaa Pro Gln Ser Ser Ile Ile Cys Tyr Gly Gln Leu Gly 
            100                 105                 110         


Ser Phe Ser Asn Cys Ser His Ser Arg Asn Asp Met Cys His Ser Leu 
        115                 120                 125             


Gly Leu Xaa Cys Leu Glu Pro Gln Lys Xaa Xaa Pro Pro Xaa Xaa Arg 
    130                 135                 140                 


Pro Pro Pro Xaa Xaa Xaa Pro Glu Pro Xaa Ala Pro Pro Arg Leu Gln 
145                 150                 155                 160 


Leu Val Ala Gln Ser Gly Gly Gln His Cys Ala Gly Val Val Glu Phe 
                165                 170                 175     


Tyr Ser Gly Ser Leu Gly Gly Xaa Ile Ser Tyr Glu Ala Gln Asp Lys 
            180                 185                 190         


Xaa Gln Asp Leu Glu Asn Phe Leu Cys Asn Asn Leu Gln Cys Gly Ser 
        195                 200                 205             


Phe Leu Lys His Leu Pro Glu Xaa Glu Ala Gly Arg Ala Gln Asp Pro 
    210                 215                 220                 


Gly Glu Pro Arg Glu His Gln Pro Leu Pro Ile Gln Trp Lys Ile Gln 
225                 230                 235                 240 


Asn Ser Ser Cys Xaa Ser Leu Glu His Cys Phe Arg Lys Ile Lys Pro 
                245                 250                 255     


Gln Lys Ser Gly Arg Val Leu Ala Leu Leu Cys Ser Gly Phe Gln Pro 
            260                 265                 270         


Lys Val Gln Ser Arg Leu Val Gly Gly Ser Ser Ile Cys Glu Gly Xaa 
        275                 280                 285             


Val Glu Val Arg Gln Gly Ala Gln Trp Ala Ala Leu Cys Asp Ser Ser 
    290                 295                 300                 


Ser Ala Arg Ser Ser Leu Arg Trp Glu Glu Val Cys Arg Glu Gln Gln 
305                 310                 315                 320 


Cys Gly Ser Val Asn Ser Tyr Arg Val Leu Asp Ala Gly Asp Pro Xaa 
                325                 330                 335     


Ser Arg Gly Leu Phe Cys Pro His Gln Lys Leu Ser Gln Cys His Glu 
            340                 345                 350         


Leu Trp Glu Arg Asn Ser Tyr Cys Lys Lys Val Phe Val Xaa Cys Gln 
        355                 360                 365             


Asp Pro Asn Pro Ala Gly Leu Ala Ala Gly Xaa Val Ala Ser Ile Ile 
    370                 375                 380                 


Leu Ala Leu Val Leu Leu Val Val Leu Leu Val Val Cys Gly Pro Leu 
385                 390                 395                 400 


Ala Tyr Lys Lys Leu Val Lys Lys Phe Arg Gln Lys Lys Gln Arg Gln 
                405                 410                 415     


Trp Ile Gly Pro Xaa Gly Met Asn Gln Asn Met Ser Phe His Arg Asn 
            420                 425                 430         


His Xaa Ala Xaa Val Arg Ser His Ala Glu Asn Pro Xaa Ala Ser His 
        435                 440                 445             


Val Asp Asn Glu Tyr Ser Gln Pro Pro Arg Asn Ser His Leu Ser Ala 
    450                 455                 460                 


Tyr Pro Ala Leu Glu Gly Ala Leu His Arg Ser Ser Met Gln Pro Asp 
465                 470                 475                 480 


Asn Ser Ser Asp Ser Asp Tyr Asp Leu His Gly Ala Gln Arg Leu 
                485                 490                 495 


<210> 5518
<211> 219
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<400> 5518
Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Xaa Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Xaa Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Xaa Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Xaa Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Xaa Ser Asp Trp Xaa Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Xaa Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Xaa Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Xaa Ser Gln Xaa Ile Gly Leu 
    210                 215                 


<210> 5519
<211> 317
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<400> 5519
Met Xaa Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Xaa Ser Phe Pro Glu Asp Xaa Val Ile Xaa Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Gln 
                85                  90                  95      


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
            100                 105                 110         


Pro Gly Gly Ile Leu Phe Gly Ala Xaa Ile Ser Phe Ser Cys Asn Xaa 
        115                 120                 125             


Gly Tyr Lys Leu Phe Gly Ser Xaa Ser Ser Phe Cys Leu Ile Ser Gly 
    130                 135                 140                 


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
145                 150                 155                 160 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
                165                 170                 175     


Asp His Tyr Gly Tyr Arg Gln Ser Val Xaa Tyr Ala Cys Asn Lys Gly 
            180                 185                 190         


Phe Xaa Met Ile Gly Glu His Ser Ile Tyr Cys Xaa Val Asn Asn Asp 
        195                 200                 205             


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
    210                 215                 220                 


Xaa Ser Lys Val Pro Pro Xaa Val Gln Lys Pro Xaa Xaa Val Asn Val 
225                 230                 235                 240 


Pro Xaa Xaa Glu Val Ser Pro Xaa Ser Gln Lys Xaa Xaa Xaa Lys Xaa 
                245                 250                 255     


Xaa Xaa Pro Asn Ala Gln Ala Xaa Arg Ser Xaa Pro Val Ser Arg Xaa 
            260                 265                 270         


Xaa Lys His Phe His Glu Xaa Xaa Pro Asn Lys Gly Ser Gly Xaa Xaa 
        275                 280                 285             


Ser Gly Xaa Xaa Arg Leu Leu Ser Gly His Xaa Cys Phe Xaa Leu Xaa 
    290                 295                 300                 


Gly Leu Leu Gly Xaa Leu Val Xaa Met Gly Leu Leu Xaa 
305                 310                 315         


<210> 5520
<211> 381
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<400> 5520
Met Xaa Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Xaa Ser Phe Pro Glu Asp Xaa Val Ile Xaa Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Xaa Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Xaa Gln Asn Tyr Phe Pro Val Gly Xaa Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Xaa 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Xaa Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Xaa Ile Ser Phe Ser Cys Asn Xaa 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Xaa Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Xaa Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Xaa Met Ile Gly Glu His Ser Ile Tyr Cys Xaa Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Xaa Ser Lys Val Pro Pro Xaa Val Gln Lys Pro Xaa Xaa Val Asn Val 
    290                 295                 300                 


Pro Xaa Xaa Glu Val Ser Pro Xaa Ser Gln Lys Xaa Xaa Xaa Lys Xaa 
305                 310                 315                 320 


Xaa Xaa Pro Asn Ala Gln Ala Xaa Arg Ser Xaa Pro Val Ser Arg Xaa 
                325                 330                 335     


Xaa Lys His Phe His Glu Xaa Xaa Pro Asn Lys Gly Ser Gly Xaa Xaa 
            340                 345                 350         


Ser Gly Xaa Xaa Arg Leu Leu Ser Gly His Xaa Cys Phe Xaa Leu Xaa 
        355                 360                 365             


Gly Leu Leu Gly Xaa Leu Val Xaa Met Gly Leu Leu Xaa 
    370                 375                 380     


<210> 5521
<211> 440
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<400> 5521
Met Xaa Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Xaa Ser Phe Pro Glu Asp Xaa Val Ile Xaa Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Xaa Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Xaa Gln Asn Tyr Phe Pro Val Gly Xaa Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Xaa 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Xaa Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Xaa Ile Ser Phe Ser Cys Asn Xaa 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Xaa Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Xaa Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Xaa Met Ile Gly Glu His Ser Ile Tyr Cys Xaa Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Xaa Ser Lys Val Pro Pro Xaa Val Gln Lys Pro Xaa Xaa Val Asn Val 
    290                 295                 300                 


Pro Xaa Xaa Glu Val Ser Pro Xaa Ser Gln Lys Xaa Xaa Xaa Lys Xaa 
305                 310                 315                 320 


Xaa Xaa Pro Asn Ala Gln Ala Xaa Arg Ser Xaa Pro Val Ser Arg Xaa 
                325                 330                 335     


Xaa Lys His Phe His Glu Xaa Xaa Pro Asn Lys Gly Ser Gly Xaa Xaa 
            340                 345                 350         


Ser Gly Xaa Xaa Arg Leu Leu Ser Gly Ser Arg Pro Val Xaa Gln Ala 
        355                 360                 365             


Gly Met Arg Trp Cys Asp Arg Ser Ser Leu Gln Ser Arg Xaa Pro Gly 
    370                 375                 380                 


Phe Lys Arg Ser Phe His Phe Ser Leu Pro Ser Ser Trp Tyr Tyr Arg 
385                 390                 395                 400 


Ala His Val Phe His Val Asp Arg Phe Ala Trp Asp Ala Ser Asn His 
                405                 410                 415     


Gly Leu Ala Asp Leu Ala Lys Glu Glu Leu Arg Arg Lys Tyr Xaa Gln 
            420                 425                 430         


Val Tyr Arg Leu Phe Leu Val Ser 
        435                 440 


<210> 5522
<211> 444
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<400> 5522
Met Xaa Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Xaa Ser Phe Pro Glu Asp Xaa Val Ile Xaa Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Xaa Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Xaa Gln Asn Tyr Phe Pro Val Gly Xaa Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Xaa 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Xaa Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Xaa Ile Ser Phe Ser Cys Asn Xaa 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Xaa Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Xaa Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Xaa Met Ile Gly Glu His Ser Ile Tyr Cys Xaa Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Xaa Ser Lys Val Pro Pro Xaa Val Gln Lys Pro Xaa Xaa Val Asn Val 
    290                 295                 300                 


Pro Xaa Xaa Glu Val Ser Pro Xaa Ser Gln Lys Xaa Xaa Xaa Lys Xaa 
305                 310                 315                 320 


Xaa Xaa Pro Asn Ala Gln Ala Xaa Arg Ser Xaa Pro Val Ser Arg Xaa 
                325                 330                 335     


Xaa Lys His Phe His Glu Xaa Xaa Pro Asn Lys Gly Ser Gly Xaa Xaa 
            340                 345                 350         


Ser Gly Xaa Xaa Arg Leu Leu Ser Gly Ser Arg Pro Val Xaa Gln Ala 
        355                 360                 365             


Gly Met Arg Trp Cys Asp Arg Ser Ser Leu Gln Ser Arg Xaa Pro Gly 
    370                 375                 380                 


Phe Lys Arg Ser Phe His Phe Ser Leu Pro Ser Ser Trp Tyr Tyr Arg 
385                 390                 395                 400 


Cys Val Pro Arg His Pro Ala Lys Phe Leu Lys Phe Ile Phe Cys Arg 
                405                 410                 415     


Asp Arg Ile Phe Leu Cys Cys Pro Gly Trp Phe Gln Xaa Pro Gly Arg 
            420                 425                 430         


Lys Arg Phe Phe Arg Pro Pro Lys Xaa Leu Arg Leu 
        435                 440                 


<210> 5523
<211> 550
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<400> 5523
Met Xaa Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Xaa Ser Phe Pro Glu Asp Xaa Val Ile Xaa Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Xaa Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Xaa Gln Asn Tyr Phe Pro Val Gly Xaa Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Xaa 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Xaa Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Xaa Ile Ser Phe Ser Cys Asn Xaa 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Xaa Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Xaa Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Xaa Met Ile Gly Glu His Ser Ile Tyr Cys Xaa Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Xaa Ser Lys Val Pro Pro Xaa Val Gln Lys Pro Xaa Xaa Val Asn Val 
    290                 295                 300                 


Pro Xaa Xaa Glu Val Ser Pro Xaa Ser Gln Lys Xaa Xaa Xaa Lys Xaa 
305                 310                 315                 320 


Xaa Xaa Pro Asn Ala Gln Gly Xaa Glu Xaa Pro Ser Val Leu Gln Lys 
                325                 330                 335     


His Xaa Xaa Glu Asn Val Ser Ala Xaa Arg Xaa Pro Pro Xaa Pro Gln 
            340                 345                 350         


Lys Pro Xaa Xaa Val Asn Val Pro Ala Xaa Ile Val Xaa Pro Xaa Pro 
        355                 360                 365             


Lys Pro Xaa Xaa Ile Asn Val Pro Ala Xaa Gly Val Ser Ser Xaa Pro 
    370                 375                 380                 


Gln Arg His Xaa Ile Val Asn Val Ser Ala Xaa Gly Xaa Leu Pro Xaa 
385                 390                 395                 400 


Leu Gln Lys Pro Xaa Arg Ala Asn Asp Ser Ala Xaa Lys Ser Pro Ala 
                405                 410                 415     


Ala Ala Gln Xaa Ser Phe Ile Ser Lys Xaa Leu Ser Xaa Lys Xaa Pro 
            420                 425                 430         


Ser Ala Ala Gln Asn Pro Met Met Xaa Asn Ala Ser Ala Xaa Gln Ala 
        435                 440                 445             


Xaa Leu Xaa Ala Gln Lys Phe Xaa Xaa Ala Lys Val Ala Phe Xaa Gln 
    450                 455                 460                 


Ser Pro Ser Ala Ala Arg Lys Ser Xaa Asn Val His Ser Pro Val Xaa 
465                 470                 475                 480 


Asn Gly Leu Lys Ser Xaa Gln Arg Phe Pro Ser Ala His Ile Xaa Ala 
                485                 490                 495     


Xaa Arg Ser Xaa Pro Val Ser Arg Xaa Xaa Lys His Phe His Glu Xaa 
            500                 505                 510         


Xaa Pro Asn Lys Gly Ser Gly Xaa Xaa Ser Gly Xaa Xaa Arg Leu Leu 
        515                 520                 525             


Ser Gly His Xaa Cys Phe Xaa Leu Xaa Gly Leu Leu Gly Xaa Leu Val 
    530                 535                 540                 


Xaa Met Gly Leu Leu Xaa 
545                 550 


<210> 5524
<211> 326
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<400> 5524
Xaa Ala Ala Leu Pro Leu Leu Gly Glu Leu Pro Arg Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Leu Cys Leu Pro Ala Val Trp Glu Ser Ser Arg Val Glu His 
            20                  25                  30          


Xaa Met Leu Gln Xaa Cys Met Ser Ser Leu Ser Gly Asp Cys Gly Leu 
        35                  40                  45              


Pro Pro Asp Val Pro Asn Ala Gln Pro Ala Leu Glu Gly Arg Xaa Ser 
    50                  55                  60                  


Phe Pro Glu Asp Xaa Val Ile Xaa Tyr Lys Cys Glu Glu Ser Phe Val 
65                  70                  75                  80  


Lys Ile Pro Gly Glu Lys Asp Ser Val Ile Cys Leu Lys Gly Ser Gln 
                85                  90                  95      


Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg Ser Cys Glu Val Pro Xaa 
            100                 105                 110         


Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro Tyr Ile Xaa Gln Asn Tyr 
        115                 120                 125             


Phe Pro Val Gly Xaa Val Val Glu Tyr Glu Cys Arg Pro Gly Tyr Arg 
    130                 135                 140                 


Arg Glu Pro Ser Leu Ser Pro Lys Leu Xaa Cys Leu Gln Asn Leu Lys 
145                 150                 155                 160 


Trp Ser Xaa Ala Val Glu Phe Cys Lys Lys Lys Ser Cys Pro Asn Pro 
                165                 170                 175     


Gly Glu Ile Arg Asn Gly Gln Ile Asp Val Pro Gly Gly Ile Leu Phe 
            180                 185                 190         


Gly Ala Xaa Ile Ser Phe Ser Cys Asn Xaa Gly Tyr Lys Leu Phe Gly 
        195                 200                 205             


Ser Xaa Ser Ser Phe Cys Leu Ile Ser Gly Ser Ser Val Gln Trp Ser 
    210                 215                 220                 


Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr Cys Pro Ala Pro Pro Gln 
225                 230                 235                 240 


Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg Asp His Tyr Gly Tyr Arg 
                245                 250                 255     


Gln Ser Val Xaa Tyr Ala Cys Asn Lys Gly Phe Xaa Met Ile Gly Glu 
            260                 265                 270         


His Ser Ile Tyr Cys Xaa Val Asn Asn Asp Glu Gly Glu Trp Ser Gly 
        275                 280                 285             


Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu Xaa Ser Lys Val Pro Pro 
    290                 295                 300                 


Xaa Val Gln Lys Pro Xaa Xaa Val Asn Val Pro Xaa Xaa Glu Val Ser 
305                 310                 315                 320 


Pro Xaa Ser Gln Lys Xaa 
                325     


<210> 5525
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<400> 5525
Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Xaa Ala Asp Cys Lys Xaa Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Xaa Lys Ala Glu Leu Gly Tyr His Tyr Val Ala 
    50                  55                  60                  


Gln Ala Gly Arg Arg Gln Ser Ser His Phe Ser Leu Leu Lys Cys Trp 
65                  70                  75                  80  


Asp Tyr Arg Cys Glu Pro Ser His Trp Pro His Cys Pro Tyr Phe Asn 
                85                  90                  95      


Trp Gly Tyr Lys Cys Ile Xaa Ser Val Gly Ser Leu Ser Ile Ala Ile 
            100                 105                 110         


Ser Xaa Xaa Ser Gln Pro Ala 
        115                 


<210> 5526
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<400> 5526
Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Xaa Ala Asp Cys Lys Xaa Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Xaa Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Xaa Xaa Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Xaa Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Asp Xaa Phe Leu Lys Ala Leu Lys Asp Glu 
            100                 105                 110         


Lys Leu Gln Gly Leu Lys Xaa Lys Gln Pro Gly Lys Lys Ser Ala Ser 
        115                 120                 125             


Leu Ser 
    130 


<210> 5527
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 5527
Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Xaa Ala Asp Cys Lys Xaa Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Xaa Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Xaa Xaa Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Xaa Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Xaa Ser Leu Ser Glu Lys Xaa Val 
            100                 105                 110         


Leu Leu Leu Val Xaa Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             


<210> 5528
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<400> 5528
Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Xaa Ala Asp Cys Lys Xaa Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Xaa Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Xaa Xaa Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Xaa Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Ser Glu Pro Gly Ala 
            100                 105             


<210> 5529
<211> 52
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<400> 5529
Xaa Arg Leu Arg Glu Asn Glu Leu Xaa Tyr Tyr Cys Cys Lys Lys Asp 
1               5                   10                  15      


Leu Cys Asn Phe Asn Glu Gln Leu Glu Asn Gly Gly Xaa Ser Leu Ser 
            20                  25                  30          


Glu Lys Xaa Val Leu Leu Leu Val Xaa Pro Phe Leu Ala Ala Ala Trp 
        35                  40                  45              


Ser Leu His Pro 
    50          


<210> 5530
<211> 38
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<400> 5530
Met Trp Leu Phe Phe Gly Ile Xaa Gly Leu Leu Xaa Ala Ala Leu Ser 
1               5                   10                  15      


Gly Cys Xaa Val Ala Lys Trp Ile Gln Leu Leu Gly Glu Ile Cys Cys 
            20                  25                  30          


Phe Ala Gly Met Gly Phe 
        35              


<210> 5531
<211> 278
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<400> 5531
Met Trp Leu Phe Phe Gly Ile Xaa Gly Leu Leu Xaa Ala Ala Leu Ser 
1               5                   10                  15      


Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Xaa Ser Ser Ala 
            20                  25                  30          


Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Xaa 
        35                  40                  45              


Asn Gly Ser Ser Ser Cys Ser Gly Xaa Val Glu Val Arg Leu Glu Ala 
    50                  55                  60                  


Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu 
65                  70                  75                  80  


Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln 
                85                  90                  95      


Leu Ala Pro Pro Xaa Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn 
            100                 105                 110         


Xaa Ser Val Ala Ala Asn Ala Xaa Leu Ala Gly Ala Pro Ala Leu Leu 
        115                 120                 125             


Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys 
    130                 135                 140                 


Arg Ser Asp Gly Arg Arg Ala Arg Val Xaa Cys Ala Glu Asn Arg Ala 
145                 150                 155                 160 


Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met 
                165                 170                 175     


Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Xaa Trp Asp Leu 
            180                 185                 190         


Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val 
        195                 200                 205             


Gln Ala Leu Pro Gly Leu His Phe Xaa Pro Gly Arg Gly Pro Ile His 
    210                 215                 220                 


Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys 
225                 230                 235                 240 


Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly 
                245                 250                 255     


Ala Val Cys Ser Glu Ser Ser Val Xaa Val Lys Ile Glu Asn Lys Glu 
            260                 265                 270         


Ser Arg Glu Leu Met Leu 
        275             


<210> 5532
<211> 422
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<400> 5532
Met Trp Leu Phe Phe Gly Ile Xaa Gly Leu Leu Xaa Ala Ala Leu Ser 
1               5                   10                  15      


Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Xaa Ser Ser Ala 
            20                  25                  30          


Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Xaa 
        35                  40                  45              


Asn Gly Ser Ser Ser Cys Ser Gly Xaa Val Glu Val Arg Leu Glu Ala 
    50                  55                  60                  


Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu 
65                  70                  75                  80  


Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln 
                85                  90                  95      


Leu Ala Pro Pro Xaa Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn 
            100                 105                 110         


Xaa Ser Val Ala Ala Asn Ala Xaa Leu Ala Gly Ala Pro Ala Leu Leu 
        115                 120                 125             


Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys 
    130                 135                 140                 


Arg Ser Asp Gly Arg Arg Ala Arg Val Xaa Cys Ala Glu Asn Arg Ala 
145                 150                 155                 160 


Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met 
                165                 170                 175     


Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Xaa Trp Asp Leu 
            180                 185                 190         


Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val 
        195                 200                 205             


Gln Ala Leu Pro Gly Leu His Phe Xaa Pro Gly Arg Gly Pro Ile His 
    210                 215                 220                 


Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys 
225                 230                 235                 240 


Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly 
                245                 250                 255     


Ala Val Cys Ser Ala Ser Arg Ser Leu His Asn Leu Ser Xaa Pro Glu 
            260                 265                 270         


Val Pro Ala Ser Val Gln Xaa Val Xaa Ile Glu Ser Ser Val Xaa Val 
        275                 280                 285             


Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met Leu Leu Ile Pro Ser 
    290                 295                 300                 


Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu Ile Phe Ile Ala Phe 
305                 310                 315                 320 


Ile Leu Leu Arg Ile Lys Gly Lys Tyr Val Phe Met Leu Pro Ile Gln 
                325                 330                 335     


Val Gln Ala Pro Pro Pro Glu Asp Ser Asp Ser Gly Ser Asp Ser Asp 
            340                 345                 350         


Tyr Glu His Tyr Asp Phe Ser Ala Gln Pro Pro Val Ala Leu Xaa Xaa 
        355                 360                 365             


Phe Tyr Asn Ser Gln Arg His Arg Val Xaa Asp Glu Glu Val Gln Gln 
    370                 375                 380                 


Ser Arg Phe Gln Met Pro Pro Leu Glu Glu Gly Leu Glu Glu Leu His 
385                 390                 395                 400 


Ala Ser His Ile Pro Xaa Ala Asn Pro Gly His Cys Ile Xaa Asp Pro 
                405                 410                 415     


Pro Ser Leu Gly Pro Gln 
            420         


<210> 5533
<211> 468
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<400> 5533
Met Trp Leu Phe Phe Gly Ile Xaa Gly Leu Leu Xaa Ala Ala Leu Ser 
1               5                   10                  15      


Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Xaa Ser Ser Ala 
            20                  25                  30          


Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Xaa 
        35                  40                  45              


Asn Gly Ser Ser Ser Cys Ser Gly Xaa Val Glu Val Arg Leu Glu Ala 
    50                  55                  60                  


Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu 
65                  70                  75                  80  


Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln 
                85                  90                  95      


Leu Ala Pro Pro Xaa Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn 
            100                 105                 110         


Xaa Ser Val Ala Ala Asn Ala Xaa Leu Ala Gly Ala Pro Ala Leu Leu 
        115                 120                 125             


Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys 
    130                 135                 140                 


Arg Ser Asp Gly Arg Arg Ala Arg Val Xaa Cys Ala Glu Asn Arg Ala 
145                 150                 155                 160 


Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met 
                165                 170                 175     


Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Xaa Trp Asp Leu 
            180                 185                 190         


Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val 
        195                 200                 205             


Gln Ala Leu Pro Gly Leu His Phe Xaa Pro Gly Arg Gly Pro Ile His 
    210                 215                 220                 


Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys 
225                 230                 235                 240 


Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly 
                245                 250                 255     


Ala Val Cys Ser Glu His Gln Ser Trp Arg Leu Xaa Gly Gly Ala Asp 
            260                 265                 270         


Arg Cys Glu Gly Gln Val Glu Val His Phe Arg Gly Val Trp Asn Xaa 
        275                 280                 285             


Val Cys Asp Ser Glu Trp Tyr Pro Ser Glu Ala Lys Val Leu Cys Gln 
    290                 295                 300                 


Ser Leu Gly Cys Gly Xaa Ala Val Glu Arg Pro Lys Gly Leu Pro His 
305                 310                 315                 320 


Ser Leu Ser Gly Arg Met Tyr Tyr Ser Cys Asn Gly Glu Glu Leu Xaa 
                325                 330                 335     


Leu Ser Asn Cys Ser Trp Arg Phe Asn Asn Ser Asn Leu Cys Ser Gln 
            340                 345                 350         


Ser Leu Ala Ala Arg Val Leu Cys Ser Ala Ser Arg Ser Leu His Asn 
        355                 360                 365             


Leu Ser Xaa Pro Glu Val Pro Ala Ser Val Gln Xaa Val Xaa Ile Glu 
    370                 375                 380                 


Ser Ser Val Xaa Val Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met 
385                 390                 395                 400 


Leu Leu Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu 
                405                 410                 415     


Ile Phe Ile Ala Phe Ile Leu Leu Arg Ile Lys Gly Lys Tyr Ala Leu 
            420                 425                 430         


Pro Val Met Val Asn His Gln His Leu Pro Xaa Xaa Ile Pro Ala Gly 
        435                 440                 445             


Ser Asn Ser Tyr Gln Pro Val Pro Ile Xaa Ile Pro Lys Glu Gly Pro 
    450                 455                 460                 


Gly Pro Ala Pro 
465             


<210> 5534
<211> 592
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<400> 5534
Met Trp Leu Phe Phe Gly Ile Xaa Gly Leu Leu Xaa Ala Ala Leu Ser 
1               5                   10                  15      


Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Xaa Ser Ser Ala 
            20                  25                  30          


Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Xaa 
        35                  40                  45              


Asn Gly Ser Ser Ser Cys Ser Gly Xaa Val Glu Val Arg Leu Glu Ala 
    50                  55                  60                  


Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu 
65                  70                  75                  80  


Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln 
                85                  90                  95      


Leu Ala Pro Pro Xaa Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn 
            100                 105                 110         


Xaa Ser Val Ala Ala Asn Ala Xaa Leu Ala Gly Ala Pro Ala Leu Leu 
        115                 120                 125             


Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys 
    130                 135                 140                 


Arg Ser Asp Gly Arg Arg Ala Arg Val Xaa Cys Ala Glu Asn Arg Ala 
145                 150                 155                 160 


Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met 
                165                 170                 175     


Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Xaa Trp Asp Leu 
            180                 185                 190         


Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val 
        195                 200                 205             


Gln Ala Leu Pro Gly Leu His Phe Xaa Pro Gly Arg Gly Pro Ile His 
    210                 215                 220                 


Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys 
225                 230                 235                 240 


Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly 
                245                 250                 255     


Ala Val Cys Ser Glu His Gln Ser Trp Arg Leu Xaa Gly Gly Ala Asp 
            260                 265                 270         


Arg Cys Glu Gly Gln Val Glu Val His Phe Arg Gly Val Trp Asn Xaa 
        275                 280                 285             


Val Cys Asp Ser Glu Trp Tyr Pro Ser Glu Ala Lys Val Leu Cys Gln 
    290                 295                 300                 


Ser Leu Gly Cys Gly Xaa Ala Val Glu Arg Pro Lys Gly Leu Pro His 
305                 310                 315                 320 


Ser Leu Ser Gly Arg Met Tyr Tyr Ser Cys Asn Gly Glu Glu Leu Xaa 
                325                 330                 335     


Leu Ser Asn Cys Ser Trp Arg Phe Asn Asn Ser Asn Leu Cys Ser Gln 
            340                 345                 350         


Ser Leu Ala Ala Arg Val Leu Cys Ser Ala Ser Arg Ser Leu His Asn 
        355                 360                 365             


Leu Ser Xaa Pro Glu Val Pro Ala Ser Val Gln Xaa Val Xaa Ile Glu 
    370                 375                 380                 


Ser Ser Val Xaa Val Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met 
385                 390                 395                 400 


Leu Leu Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu 
                405                 410                 415     


Ile Phe Ile Ala Phe Ile Leu Leu Arg Ile Lys Gly Lys Tyr Ala Leu 
            420                 425                 430         


Pro Val Met Val Asn His Gln His Leu Pro Xaa Xaa Ile Pro Ala Gly 
        435                 440                 445             


Ser Asn Ser Tyr Gln Pro Val Pro Ile Xaa Ile Pro Lys Glu Asp Ser 
    450                 455                 460                 


Gln Arg His Arg Val Xaa Asp Glu Glu Val Gln Gln Ser Arg Phe Gln 
465                 470                 475                 480 


Met Pro Pro Leu Glu Glu Gly Leu Glu Glu Leu His Ala Ser His Ile 
                485                 490                 495     


Pro Xaa Ala Asn Pro Gly His Cys Ile Xaa Asp Pro Pro Ser Leu Gly 
            500                 505                 510         


Pro Gln Tyr His Pro Arg Ser Asn Ser Glu Ser Ser Xaa Ser Ser Gly 
        515                 520                 525             


Glu Asp Tyr Cys Asn Ser Pro Lys Ser Lys Leu Pro Pro Trp Asn Pro 
    530                 535                 540                 


Gln Val Phe Ser Ser Glu Arg Ser Ser Phe Leu Glu Gln Pro Pro Asn 
545                 550                 555                 560 


Leu Glu Leu Ala Gly Xaa Gln Pro Ala Phe Ser Gly Ser Pro Ser Pro 
                565                 570                 575     


Gln Pro Asp Ser Xaa Asp Asn Asp Asp Tyr Asp Asp Ile Ser Ala Ala 
            580                 585                 590         


<210> 5535
<211> 601
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<400> 5535
Met Trp Leu Phe Phe Gly Ile Xaa Gly Leu Leu Xaa Ala Ala Leu Ser 
1               5                   10                  15      


Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Xaa Ser Ser Ala 
            20                  25                  30          


Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Xaa 
        35                  40                  45              


Asn Gly Ser Ser Ser Cys Ser Gly Xaa Val Glu Val Arg Leu Glu Ala 
    50                  55                  60                  


Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu 
65                  70                  75                  80  


Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln 
                85                  90                  95      


Leu Ala Pro Pro Xaa Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn 
            100                 105                 110         


Xaa Ser Val Ala Ala Asn Ala Xaa Leu Ala Gly Ala Pro Ala Leu Leu 
        115                 120                 125             


Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys 
    130                 135                 140                 


Arg Ser Asp Gly Arg Arg Ala Arg Val Xaa Cys Ala Glu Asn Arg Ala 
145                 150                 155                 160 


Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met 
                165                 170                 175     


Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Xaa Trp Asp Leu 
            180                 185                 190         


Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val 
        195                 200                 205             


Gln Ala Leu Pro Gly Leu His Phe Xaa Pro Gly Arg Gly Pro Ile His 
    210                 215                 220                 


Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys 
225                 230                 235                 240 


Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly 
                245                 250                 255     


Ala Val Cys Ser Glu His Gln Ser Trp Arg Leu Xaa Gly Gly Ala Asp 
            260                 265                 270         


Arg Cys Glu Gly Gln Val Glu Val His Phe Arg Gly Val Trp Asn Xaa 
        275                 280                 285             


Val Cys Asp Ser Glu Trp Tyr Pro Ser Glu Ala Lys Val Leu Cys Gln 
    290                 295                 300                 


Ser Leu Gly Cys Gly Xaa Ala Val Glu Arg Pro Lys Gly Leu Pro His 
305                 310                 315                 320 


Ser Leu Ser Gly Arg Met Tyr Tyr Ser Cys Asn Gly Glu Glu Leu Xaa 
                325                 330                 335     


Leu Ser Asn Cys Ser Trp Arg Phe Asn Asn Ser Asn Leu Cys Ser Gln 
            340                 345                 350         


Ser Leu Ala Ala Arg Val Leu Cys Ser Ala Ser Arg Ser Leu His Asn 
        355                 360                 365             


Leu Ser Xaa Pro Glu Val Pro Ala Ser Val Gln Xaa Val Xaa Ile Glu 
    370                 375                 380                 


Ser Ser Val Xaa Val Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met 
385                 390                 395                 400 


Leu Leu Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu 
                405                 410                 415     


Ile Phe Ile Ala Phe Ile Leu Leu Arg Ile Lys Gly Lys Tyr Val Phe 
            420                 425                 430         


Met Leu Pro Ile Gln Val Gln Ala Pro Pro Pro Glu Asp Ser Asp Ser 
        435                 440                 445             


Gly Ser Asp Ser Asp Tyr Glu His Tyr Asp Phe Ser Ala Gln Pro Pro 
    450                 455                 460                 


Val Ala Leu Xaa Xaa Phe Tyr Asn Ser Gln Arg His Arg Val Xaa Asp 
465                 470                 475                 480 


Glu Glu Val Gln Gln Ser Arg Phe Gln Met Pro Pro Leu Glu Glu Gly 
                485                 490                 495     


Leu Glu Glu Leu His Ala Ser His Ile Pro Xaa Ala Asn Pro Gly His 
            500                 505                 510         


Cys Ile Xaa Asp Pro Pro Ser Leu Gly Pro Gln Tyr His Pro Arg Ser 
        515                 520                 525             


Asn Ser Glu Ser Ser Xaa Ser Ser Gly Glu Asp Tyr Cys Asn Ser Pro 
    530                 535                 540                 


Lys Ser Lys Leu Pro Pro Trp Asn Pro Gln Val Phe Ser Ser Glu Arg 
545                 550                 555                 560 


Ser Ser Phe Leu Glu Gln Pro Pro Asn Leu Glu Leu Ala Gly Xaa Gln 
                565                 570                 575     


Pro Ala Phe Ser Gly Ser Pro Ser Pro Gln Pro Asp Ser Xaa Asp Asn 
            580                 585                 590         


Asp Asp Tyr Asp Asp Ile Ser Ala Ala 
        595                 600     


<210> 5536
<211> 668
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<400> 5536
Met Trp Leu Phe Phe Gly Ile Xaa Gly Leu Leu Xaa Ala Ala Leu Ser 
1               5                   10                  15      


Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Xaa Ser Ser Ala 
            20                  25                  30          


Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Xaa 
        35                  40                  45              


Asn Gly Ser Ser Ser Cys Ser Gly Xaa Val Glu Val Arg Leu Glu Ala 
    50                  55                  60                  


Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu 
65                  70                  75                  80  


Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln 
                85                  90                  95      


Leu Ala Pro Pro Xaa Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn 
            100                 105                 110         


Xaa Ser Val Ala Ala Asn Ala Xaa Leu Ala Gly Ala Pro Ala Leu Leu 
        115                 120                 125             


Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys 
    130                 135                 140                 


Arg Ser Asp Gly Arg Arg Ala Arg Val Xaa Cys Ala Glu Asn Arg Ala 
145                 150                 155                 160 


Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met 
                165                 170                 175     


Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Xaa Trp Asp Leu 
            180                 185                 190         


Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val 
        195                 200                 205             


Gln Ala Leu Pro Gly Leu His Phe Xaa Pro Gly Arg Gly Pro Ile His 
    210                 215                 220                 


Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys 
225                 230                 235                 240 


Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly 
                245                 250                 255     


Ala Val Cys Ser Glu His Gln Ser Trp Arg Leu Xaa Gly Gly Ala Asp 
            260                 265                 270         


Arg Cys Glu Gly Gln Val Glu Val His Phe Arg Gly Val Trp Asn Xaa 
        275                 280                 285             


Val Cys Asp Ser Glu Trp Tyr Pro Ser Glu Ala Lys Val Leu Cys Gln 
    290                 295                 300                 


Ser Leu Gly Cys Gly Xaa Ala Val Glu Arg Pro Lys Gly Leu Pro His 
305                 310                 315                 320 


Ser Leu Ser Gly Arg Met Tyr Tyr Ser Cys Asn Gly Glu Glu Leu Xaa 
                325                 330                 335     


Leu Ser Asn Cys Ser Trp Arg Phe Asn Asn Ser Asn Leu Cys Ser Gln 
            340                 345                 350         


Ser Leu Ala Ala Arg Val Leu Cys Ser Ala Ser Arg Ser Leu His Asn 
        355                 360                 365             


Leu Ser Xaa Pro Glu Val Pro Ala Ser Val Gln Xaa Val Xaa Ile Glu 
    370                 375                 380                 


Ser Ser Val Xaa Val Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met 
385                 390                 395                 400 


Leu Leu Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu 
                405                 410                 415     


Ile Phe Ile Ala Phe Ile Leu Leu Arg Ile Lys Gly Lys Tyr Ala Leu 
            420                 425                 430         


Pro Val Met Val Asn His Gln His Leu Pro Xaa Xaa Ile Pro Ala Gly 
        435                 440                 445             


Ser Asn Ser Tyr Gln Pro Val Pro Ile Xaa Ile Pro Lys Glu Val Phe 
    450                 455                 460                 


Met Leu Pro Ile Gln Val Gln Ala Pro Pro Pro Glu Asp Ser Asp Ser 
465                 470                 475                 480 


Gly Ser Asp Ser Asp Tyr Glu His Tyr Asp Phe Ser Ala Gln Pro Pro 
                485                 490                 495     


Val Ala Leu Xaa Xaa Phe Tyr Asn Ser Gln Arg His Arg Val Xaa Asp 
            500                 505                 510         


Glu Glu Val Gln Gln Ser Arg Phe Gln Met Pro Pro Leu Glu Glu Gly 
        515                 520                 525             


Leu Glu Glu Leu His Ala Ser His Ile Pro Xaa Ala Asn Pro Gly His 
    530                 535                 540                 


Cys Ile Xaa Asp Pro Pro Ser Leu Gly Pro Gln Tyr His Pro Arg Ser 
545                 550                 555                 560 


Asn Ser Glu Ser Ser Xaa Ser Ser Gly Glu Asp Tyr Cys Asn Ser Pro 
                565                 570                 575     


Lys Ser Lys Leu Pro Pro Trp Asn Pro Gln Val Phe Ser Ser Glu Arg 
            580                 585                 590         


Ser Ser Phe Leu Glu Gln Pro Pro Asn Leu Glu Leu Ala Gly Xaa Gln 
        595                 600                 605             


Pro Ala Phe Ser Ala Gly Pro Pro Ala Asp Asp Ser Ser Ser Xaa Ser 
    610                 615                 620                 


Ser Gly Glu Trp Tyr Gln Asn Phe Gln Pro Pro Pro Gln Pro Pro Ser 
625                 630                 635                 640 


Glu Glu Gln Phe Gly Cys Pro Gly Ser Pro Ser Pro Gln Pro Asp Ser 
                645                 650                 655     


Xaa Asp Asn Asp Asp Tyr Asp Asp Ile Ser Ala Ala 
            660                 665             


<210> 5537
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<400> 5537
Xaa Asn Arg Ala Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly 
1               5                   10                  15      


Arg Val Glu Met Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp 
            20                  25                  30          


Xaa Trp Asp Leu Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys 
        35                  40                  45              


Gly Trp Ala Val Gln Ala Leu Pro Gly Leu His Phe Xaa Pro Gly Arg 
    50                  55                  60                  


Gly Pro Ile His Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr 
65                  70                  75                  80  


Leu Trp Asp Cys Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys 
                85                  90                  95      


Glu Asp Ala Gly Ala Val Cys Ser Ala Ser Arg Ser Leu His Asn Leu 
            100                 105                 110         


Ser Xaa Pro Glu Val Pro Ala Ser Val Gln Xaa Val Xaa Ile Glu Ser 
        115                 120                 125             


Ser Val Xaa Val Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met Leu 
    130                 135                 140                 


Leu Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu Ile 
145                 150                 155                 160 


Phe Ile Ala Phe Ile Leu Leu Arg Ile Lys Gly Lys Tyr Ala Leu Pro 
                165                 170                 175     


Val Met Val Asn His Gln His Leu Pro Xaa 
            180                 185     


<210> 5538
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<400> 5538
Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Xaa Ile Ile Gln Gly Ala Xaa 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Xaa Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Xaa Ala 
    130             


<210> 5539
<211> 215
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<400> 5539
Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Xaa Ile Ile Gln Gly Ala Xaa 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Xaa Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Xaa Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Xaa Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Xaa Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe 
    210                 215 


<210> 5540
<211> 217
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<400> 5540
Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Xaa Ile Ile Gln Gly Ala Xaa 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Xaa Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Xaa Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Xaa Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Xaa Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu 
    210                 215         


<210> 5541
<211> 238
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<400> 5541
Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Xaa Ile Ile Gln Gly Ala Xaa 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Xaa Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Xaa Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Xaa Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Xaa Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
225                 230                 235             


<210> 5542
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<400> 5542
Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Xaa Ile Ile Gln Gly Ala Xaa 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Xaa Leu Pro Ser Phe Cys Leu Leu Ser Cys Trp Trp 
                85                  90                  95      


Arg Trp Pro Gln Pro Leu Leu Ala Met Cys Leu Glu Ile Arg 
            100                 105                 110 


<210> 5543
<211> 215
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<400> 5543
Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Gly Ala Xaa Pro Gly Ser Leu Leu Pro Val 
            20                  25                  30          


Val Ile Ile Ala Val Gly Val Phe Leu Phe Leu Val Ala Phe Val Gly 
        35                  40                  45              


Cys Cys Gly Ala Cys Lys Glu Asn Tyr Cys Leu Met Ile Xaa Phe Ala 
    50                  55                  60                  


Ile Phe Leu Ser Leu Ile Met Leu Val Glu Val Ala Ala Ala Ile Ala 
65                  70                  75                  80  


Gly Tyr Val Phe Arg Asp Lys Val Met Ser Glu Phe Asn Asn Asn Phe 
                85                  90                  95      


Arg Gln Gln Met Glu Asn Tyr Pro Lys Asn Asn His Xaa Ala Ser Ile 
            100                 105                 110         


Leu Asp Arg Met Gln Ala Asp Phe Lys Cys Cys Gly Ala Ala Asn Tyr 
        115                 120                 125             


Xaa Asp Trp Glu Lys Ile Pro Ser Met Ser Lys Asn Arg Val Pro Asp 
    130                 135                 140                 


Ser Cys Cys Ile Asn Val Xaa Val Gly Cys Gly Ile Asn Phe Asn Glu 
145                 150                 155                 160 


Lys Ala Ile His Lys Glu Gly Cys Val Glu Lys Ile Gly Gly Trp Leu 
                165                 170                 175     


Arg Lys Asn Val Leu Val Val Ala Ala Ala Ala Leu Gly Ile Ala Phe 
            180                 185                 190         


Val Glu Val Leu Gly Ile Val Phe Ala Cys Cys Leu Val Lys Ser Ile 
        195                 200                 205             


Arg Ser Gly Tyr Glu Val Met 
    210                 215 


<210> 5544
<211> 156
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 5544
Met Ile Xaa Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val Glu Val 
1               5                   10                  15      


Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met Ser Glu 
            20                  25                  30          


Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys Asn Asn 
        35                  40                  45              


His Xaa Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys Cys Cys 
    50                  55                  60                  


Gly Ala Ala Asn Tyr Xaa Asp Trp Glu Lys Ile Pro Ser Met Ser Lys 
65                  70                  75                  80  


Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Xaa Val Gly Cys Gly 
                85                  90                  95      


Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val Glu Lys 
            100                 105                 110         


Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala Ala Ala 
        115                 120                 125             


Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala Cys Cys 
    130                 135                 140                 


Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
145                 150                 155     


<210> 5545
<211> 145
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 5545
Met Leu Val Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp 
1               5                   10                  15      


Lys Val Met Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn 
            20                  25                  30          


Tyr Pro Lys Asn Asn His Xaa Ala Ser Ile Leu Asp Arg Met Gln Ala 
        35                  40                  45              


Asp Phe Lys Cys Cys Gly Ala Ala Asn Tyr Xaa Asp Trp Glu Lys Ile 
    50                  55                  60                  


Pro Ser Met Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val 
65                  70                  75                  80  


Xaa Val Gly Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu 
                85                  90                  95      


Gly Cys Val Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val 
            100                 105                 110         


Val Ala Ala Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile 
        115                 120                 125             


Val Phe Ala Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val 
    130                 135                 140                 


Met 
145 


<210> 5546
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<400> 5546
Met Ser Ser Glu Asn Cys Phe Val Ala Glu Asn Ser Ser Leu His Pro 
1               5                   10                  15      


Glu Ser Gly Gln Glu Asn Asp Ala Xaa Ser Pro His Phe Ser Xaa Arg 
            20                  25                  30          


His Glu Gly Ser Phe Gln Val Pro Val Leu Cys Ala Val Met Asn Val 
        35                  40                  45              


Val Phe Ile Xaa Ile Leu Ile Ile Ala Leu Ile Ala Leu Ser Val Gly 
    50                  55                  60                  


Gln Tyr Asn Cys Pro Gly Gln Tyr Xaa Phe Ser Met Pro Ser Asp Ser 
65                  70                  75                  80  


His Val Ser Ser Cys Ser Glu Asp Trp Val Gly Tyr Gln Arg Lys Cys 
                85                  90                  95      


Tyr Phe Ile Ser Xaa Val Lys Arg Ser Trp Xaa Ser Ala Gln Asn Ala 
            100                 105                 110         


Cys Ser Glu His Gly Ala Xaa Leu Ala Val Ile Asp Ser Glu Lys Asp 
        115                 120                 125             


Met Asn Phe Leu Lys Arg Tyr Ala Gly Arg Glu Glu His Trp Val Gly 
    130                 135                 140                 


Leu Lys Lys Glu Pro Gly His Pro Trp Lys Trp Ser Asn Gly Lys Glu 
145                 150                 155                 160 


Phe Asn Asn Trp 
                


<210> 5547
<211> 199
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<400> 5547
Met Ser Ser Glu Asn Cys Phe Val Ala Glu Asn Ser Ser Leu His Pro 
1               5                   10                  15      


Glu Ser Gly Gln Glu Asn Asp Ala Xaa Ser Pro His Phe Ser Xaa Arg 
            20                  25                  30          


His Glu Gly Ser Phe Gln Val Pro Val Leu Cys Ala Val Met Asn Val 
        35                  40                  45              


Val Phe Ile Xaa Ile Leu Ile Ile Ala Leu Ile Ala Leu Ser Val Gly 
    50                  55                  60                  


Gln Tyr Asn Cys Pro Gly Gln Tyr Xaa Phe Ser Met Pro Ser Asp Ser 
65                  70                  75                  80  


His Val Ser Ser Cys Ser Glu Asp Trp Val Gly Tyr Gln Arg Lys Cys 
                85                  90                  95      


Tyr Phe Ile Ser Xaa Val Lys Arg Ser Trp Xaa Ser Ala Gln Asn Ala 
            100                 105                 110         


Cys Ser Glu His Gly Ala Xaa Leu Ala Val Ile Asp Ser Glu Lys Asp 
        115                 120                 125             


Met Asn Phe Leu Lys Arg Tyr Ala Gly Arg Glu Glu His Trp Val Gly 
    130                 135                 140                 


Leu Lys Lys Glu Pro Gly His Pro Trp Lys Trp Ser Asn Gly Lys Glu 
145                 150                 155                 160 


Phe Asn Asn Trp Phe Asn Val Xaa Gly Ser Asp Lys Cys Val Phe Leu 
                165                 170                 175     


Lys Asn Xaa Glu Val Ser Ser Met Glu Cys Glu Lys Asn Leu Tyr Trp 
            180                 185                 190         


Ile Cys Asn Lys Pro Tyr Lys 
        195                 


<210> 5548
<211> 35
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<400> 5548
Met Ala Gly Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Leu Pro Gly Ala Leu Ala Ala Gln Ala Gly Ala Cys Val 
            20                  25                  30          


Gly Ser Xaa 
        35  


<210> 5549
<211> 240
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<400> 5549
Met Ala Gly Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Leu Pro Gly Ala Leu Ala Ala Gln Glu Val Gln Gln Ser 
            20                  25                  30          


Pro His Cys Xaa Xaa Val Pro Val Gly Ala Ser Val Asn Ile Xaa Cys 
        35                  40                  45              


Ser Xaa Ser Gly Gly Leu Arg Gly Ile Tyr Leu Arg Gln Leu Gly Pro 
    50                  55                  60                  


Gln Pro Gln Asp Ile Ile Tyr Tyr Glu Asp Gly Val Val Pro Xaa Xaa 
65                  70                  75                  80  


Asp Arg Arg Phe Arg Gly Arg Ile Asp Phe Ser Gly Ser Gln Asp Asn 
                85                  90                  95      


Leu Xaa Ile Xaa Met His Arg Leu Gln Leu Ser Asp Xaa Gly Xaa Tyr 
            100                 105                 110         


Xaa Cys Gln Ala Ile Xaa Glu Val Asn Val Tyr Gly Ser Gly Xaa Leu 
        115                 120                 125             


Val Leu Val Xaa Glu Glu Gln Ser Gln Gly Trp His Arg Cys Ser Asp 
    130                 135                 140                 


Ala Pro Pro Arg Ala Ser Ala Leu Pro Ala Pro Pro Xaa Gly Ser Ala 
145                 150                 155                 160 


Leu Pro Asp Pro Gln Xaa Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala 
                165                 170                 175     


Ser Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu 
            180                 185                 190         


Gly Leu Gly Val Ala Cys Val Leu Ala Arg Xaa Gln Ile Lys Lys Leu 
        195                 200                 205             


Cys Ser Trp Arg Asp Lys Asn Ser Ala Ala Cys Val Val Tyr Glu Asp 
    210                 215                 220                 


Met Ser His Ser Arg Cys Asn Xaa Leu Ser Ser Pro Asn Gln Tyr Gln 
225                 230                 235                 240 


<210> 5550
<211> 221
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<400> 5550
Met Ala Gly Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Leu Pro Gly Ala Leu Ala Ala Gln Glu Val Gln Gln Ser 
            20                  25                  30          


Pro His Cys Xaa Xaa Val Pro Val Gly Ala Ser Val Asn Ile Xaa Cys 
        35                  40                  45              


Ser Xaa Ser Gly Gly Leu Arg Gly Ile Tyr Leu Arg Gln Leu Gly Pro 
    50                  55                  60                  


Gln Pro Gln Asp Ile Ile Tyr Tyr Glu Asp Gly Val Val Pro Xaa Xaa 
65                  70                  75                  80  


Asp Arg Arg Phe Arg Gly Arg Ile Asp Phe Ser Gly Ser Gln Asp Asn 
                85                  90                  95      


Leu Xaa Ile Xaa Met His Arg Leu Gln Leu Ser Asp Xaa Gly Xaa Tyr 
            100                 105                 110         


Xaa Cys Gln Ala Ile Xaa Glu Val Asn Val Tyr Gly Ser Gly Xaa Leu 
        115                 120                 125             


Val Leu Val Xaa Glu Glu Gln Ser Gln Gly Trp His Arg Cys Ser Asp 
    130                 135                 140                 


Ala Pro Pro Arg Ala Ser Ala Leu Pro Ala Pro Pro Xaa Gly Ser Ala 
145                 150                 155                 160 


Leu Pro Asp Pro Gln Xaa Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala 
                165                 170                 175     


Ser Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu 
            180                 185                 190         


Gly Leu Gly Val Ala Cys Val Leu Ala Arg Xaa Gln Val Ser Val Ser 
        195                 200                 205             


Pro Ser Cys His Leu His Pro Lys Asp Cys Ser Leu Ser 
    210                 215                 220     


<210> 5551
<211> 160
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<400> 5551
Met Ala Gly Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Leu Pro Gly Ala Leu Ala Ala Gln Gly Arg Xaa Phe Ser 
            20                  25                  30          


Val Leu Leu Ala Arg Leu Met Val Xaa Ala Gln Val Leu Pro Arg Gly 
        35                  40                  45              


Ala Ala Val Ser Pro Leu His Asp Cys Pro Arg Gly Ser Leu Arg Gln 
    50                  55                  60                  


His His Leu Leu His Gln Arg Gly Pro Ala Trp Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Ala Arg Ala Xaa Ala Pro Arg His His Leu Leu Arg Gly Arg Gly Gly 
                85                  90                  95      


Ala His Tyr Gly Gln Xaa Val Pro Gly Pro His Arg Leu Leu Arg Val 
            100                 105                 110         


Pro Gly Gln Pro Asp Tyr His His Ala Pro Pro Ala Ala Val Gly His 
        115                 120                 125             


Trp His Leu His Leu Pro Gly His His Gly Gly Gln Cys Leu Arg Leu 
    130                 135                 140                 


Arg His Pro Gly Pro Gly Asp Arg Gly Xaa Val Pro Arg Met Ala Gln 
145                 150                 155                 160 


<210> 5552
<211> 140
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<400> 5552
Met His Arg Leu Gln Leu Ser Asp Xaa Gly Xaa Tyr Xaa Cys Gln Ala 
1               5                   10                  15      


Ile Xaa Glu Val Asn Val Tyr Gly Ser Gly Xaa Leu Val Leu Val Xaa 
            20                  25                  30          


Glu Glu Gln Ser Gln Gly Trp His Arg Cys Ser Asp Ala Pro Pro Arg 
        35                  40                  45              


Ala Ser Ala Leu Pro Ala Pro Pro Xaa Gly Ser Ala Leu Pro Asp Pro 
    50                  55                  60                  


Gln Xaa Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala Ser Ala Leu Pro 
65                  70                  75                  80  


Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu Gly Leu Gly Val 
                85                  90                  95      


Ala Cys Val Leu Ala Arg Xaa Gln Ile Lys Lys Leu Cys Ser Trp Arg 
            100                 105                 110         


Asp Lys Asn Ser Ala Ala Cys Val Val Tyr Glu Asp Met Ser His Ser 
        115                 120                 125             


Arg Cys Asn Xaa Leu Ser Ser Pro Asn Gln Tyr Gln 
    130                 135                 140 


<210> 5553
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 5553
Met His Arg Leu Gln Leu Ser Asp Xaa Gly Xaa Tyr Xaa Cys Gln Ala 
1               5                   10                  15      


Ile Xaa Glu Val Asn Val Tyr Gly Ser Gly Xaa Leu Val Leu Val Xaa 
            20                  25                  30          


Glu Glu Gln Ser Gln Gly Trp His Arg Cys Ser Asp Ala Pro Pro Arg 
        35                  40                  45              


Ala Ser Ala Leu Pro Ala Pro Pro Xaa Gly Ser Ala Leu Pro Asp Pro 
    50                  55                  60                  


Gln Xaa Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala Ser Ala Leu Pro 
65                  70                  75                  80  


Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu Gly Leu Gly Val 
                85                  90                  95      


Ala Cys Val Leu Ala Arg Xaa Gln Val Ser Val Ser Pro Ser Cys His 
            100                 105                 110         


Leu His Pro Lys Asp Cys Ser Leu Ser 
        115                 120     


<210> 5554
<211> 65
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<400> 5554
Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Xaa 
65  


<210> 5555
<211> 193
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<400> 5555
Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Xaa Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Xaa Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Xaa Xaa Ala Ser Arg His His Pro Xaa Xaa Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Xaa Ile Ala Ser Gln Arg Leu Xaa Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Xaa Leu Cys Xaa Asn Leu Xaa Gly Xaa Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Xaa Asp Glu Xaa Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210> 5556
<211> 208
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<400> 5556
Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Xaa Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Xaa Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Xaa Xaa Ala Ser Arg His His Pro Xaa Xaa Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Leu Phe Gly Phe Trp Asn Trp Gly Leu Lys 
145                 150                 155                 160 


Val Lys Cys Phe Leu Arg His Leu Ile Trp Xaa Ala His Cys Phe Ile 
                165                 170                 175     


Pro Leu Xaa Gln Leu Val Phe Met Gln Ala Leu Gln Ser Trp Arg Asn 
            180                 185                 190         


His His Cys Ser His Phe Xaa Asp Glu Glu Asn Arg Gly Val Asn Arg 
        195                 200                 205             


<210> 5557
<211> 120
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 5557
Met Ala Glu Ala Ile Xaa Tyr Ala Asp Leu Arg Phe Val Lys Ala Pro 
1               5                   10                  15      


Leu Lys Lys Ser Ile Ser Ser Arg Leu Gly Gln Asp Pro Gly Ala Asp 
            20                  25                  30          


Asp Asp Gly Glu Ile Xaa Tyr Glu Asn Val Gln Val Pro Ala Val Leu 
        35                  40                  45              


Gly Val Pro Ser Ser Leu Ala Ser Ser Val Leu Gly Asp Lys Ala Ala 
    50                  55                  60                  


Val Lys Ser Glu Gln Pro Xaa Ala Ser Trp Arg Ala Val Xaa Ser Pro 
65                  70                  75                  80  


Ala Val Gly Arg Ile Leu Pro Cys Glu Cys Ala Cys Ala Gly Gln Pro 
                85                  90                  95      


Arg Gly Gln Val Leu Ala Pro Val Pro Ala Ala Asp Gly Ala Gly Pro 
            100                 105                 110         


Arg Gly Val Gln Leu Leu Pro Gly 
        115                 120 


<210> 5558
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 5558
Met Ala Glu Ala Ile Xaa Tyr Ala Asp Leu Arg Phe Val Lys Ala Pro 
1               5                   10                  15      


Leu Lys Lys Ser Ile Ser Ser Arg Leu Gly Gln Asp Pro Gly Ala Asp 
            20                  25                  30          


Asp Asp Gly Glu Ile Xaa Tyr Glu Asn Val Gln Val Pro Ala Val Leu 
        35                  40                  45              


Gly Val Pro Ser Ser Leu Ala Ser Ser Val Leu Gly Asp Lys Ala Ala 
    50                  55                  60                  


Val Lys Ser Glu Gln Pro Xaa Ala Ser Trp Arg Ala Val Xaa Ser Pro 
65                  70                  75                  80  


Ala Val Gly Arg Ile Leu Pro Cys Arg Xaa Xaa Cys Leu Arg Tyr Leu 
                85                  90                  95      


Leu Leu Gly Leu Leu Leu Xaa Cys Leu Leu Leu Gly Val Xaa Ala Ile 
            100                 105                 110         


Cys Leu Gly Val Arg Cys Glu 
        115                 


<210> 5559
<211> 359
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<400> 5559
Met Ala Glu Ala Ile Xaa Tyr Ala Asp Leu Arg Phe Val Lys Ala Pro 
1               5                   10                  15      


Leu Lys Lys Ser Ile Ser Ser Arg Leu Gly Gln Asp Pro Gly Ala Asp 
            20                  25                  30          


Asp Asp Gly Glu Ile Xaa Tyr Glu Asn Val Gln Val Pro Ala Val Leu 
        35                  40                  45              


Gly Val Pro Ser Ser Leu Ala Ser Ser Val Leu Gly Asp Lys Ala Ala 
    50                  55                  60                  


Val Lys Ser Glu Gln Pro Xaa Ala Ser Trp Arg Ala Val Xaa Ser Pro 
65                  70                  75                  80  


Ala Val Gly Arg Ile Leu Pro Cys Arg Xaa Xaa Cys Leu Arg Tyr Leu 
                85                  90                  95      


Leu Leu Gly Leu Leu Leu Xaa Cys Leu Leu Leu Gly Val Xaa Ala Ile 
            100                 105                 110         


Cys Leu Gly Val Arg Tyr Leu Gln Val Ser Gln Gln Leu Gln Gln Xaa 
        115                 120                 125             


Asn Arg Val Leu Glu Val Xaa Asn Ser Ser Leu Arg Gln Gln Leu Arg 
    130                 135                 140                 


Leu Lys Ile Xaa Gln Leu Gly Gln Ser Ala Glu Asp Leu Gln Gly Ser 
145                 150                 155                 160 


Arg Arg Glu Leu Ala Gln Ser Gln Glu Ala Leu Gln Val Glu Gln Arg 
                165                 170                 175     


Ala His Gln Ala Ala Glu Gly Gln Leu Gln Ala Cys Gln Ala Asp Arg 
            180                 185                 190         


Gln Lys Xaa Lys Glu Xaa Leu Gln Ser Glu Glu Gln Gln Arg Arg Ala 
        195                 200                 205             


Leu Glu Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe 
    210                 215                 220                 


Xaa Cys Gly Ser Ala Asp Xaa Cys Cys Pro Ser Gly Trp Ile Met His 
225                 230                 235                 240 


Gln Lys Ser Cys Phe Tyr Ile Ser Leu Xaa Ser Lys Asn Trp Gln Glu 
                245                 250                 255     


Ser Gln Lys Gln Cys Glu Xaa Leu Ser Ser Lys Leu Ala Xaa Phe Ser 
            260                 265                 270         


Glu Ile Tyr Pro Gln Ser His Ser Tyr Tyr Phe Leu Asn Ser Leu Leu 
        275                 280                 285             


Pro Asn Gly Gly Ser Gly Asn Ser Tyr Trp Xaa Gly Leu Ser Ser Asn 
    290                 295                 300                 


Lys Asp Trp Lys Leu Xaa Asp Asp Xaa Gln Arg Xaa Arg Xaa Tyr Ala 
305                 310                 315                 320 


Gln Ser Ser Lys Cys Asn Lys Val His Lys Xaa Trp Ser Trp Trp Xaa 
                325                 330                 335     


Leu Glu Ser Glu Ser Cys Arg Ser Ser Leu Pro Tyr Ile Cys Glu Met 
            340                 345                 350         


Xaa Ala Phe Arg Phe Pro Asp 
        355                 


<210> 5560
<211> 359
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<400> 5560
Met Gln Xaa Arg Asn Pro Gln Ser His Gly Glu Asn Gly Ala Ser Pro 
1               5                   10                  15      


Trp Ser Trp Gly Asp Arg Leu Gly Pro Gly Pro Asp Pro Gly Ala Asp 
            20                  25                  30          


Asp Asp Gly Glu Ile Xaa Tyr Glu Asn Val Gln Val Pro Ala Val Leu 
        35                  40                  45              


Gly Val Pro Ser Ser Leu Ala Ser Ser Val Leu Gly Asp Lys Ala Ala 
    50                  55                  60                  


Val Lys Ser Glu Gln Pro Xaa Ala Ser Trp Arg Ala Val Xaa Ser Pro 
65                  70                  75                  80  


Ala Val Gly Arg Ile Leu Pro Cys Arg Xaa Xaa Cys Leu Arg Tyr Leu 
                85                  90                  95      


Leu Leu Gly Leu Leu Leu Xaa Cys Leu Leu Leu Gly Val Xaa Ala Ile 
            100                 105                 110         


Cys Leu Gly Val Arg Tyr Leu Gln Val Ser Gln Gln Leu Gln Gln Xaa 
        115                 120                 125             


Asn Arg Val Leu Glu Val Xaa Asn Ser Ser Leu Arg Gln Gln Leu Arg 
    130                 135                 140                 


Leu Lys Ile Xaa Gln Leu Gly Gln Ser Ala Glu Asp Leu Gln Gly Ser 
145                 150                 155                 160 


Arg Arg Glu Leu Ala Gln Ser Gln Glu Ala Leu Gln Val Glu Gln Arg 
                165                 170                 175     


Ala His Gln Ala Ala Glu Gly Gln Leu Gln Ala Cys Gln Ala Asp Arg 
            180                 185                 190         


Gln Lys Xaa Lys Glu Xaa Leu Gln Ser Glu Glu Gln Gln Arg Arg Ala 
        195                 200                 205             


Leu Glu Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe 
    210                 215                 220                 


Xaa Cys Gly Ser Ala Asp Xaa Cys Cys Pro Ser Gly Trp Ile Met His 
225                 230                 235                 240 


Gln Lys Ser Cys Phe Tyr Ile Ser Leu Xaa Ser Lys Asn Trp Gln Glu 
                245                 250                 255     


Ser Gln Lys Gln Cys Glu Xaa Leu Ser Ser Lys Leu Ala Xaa Phe Ser 
            260                 265                 270         


Glu Ile Tyr Pro Gln Ser His Ser Tyr Tyr Phe Leu Asn Ser Leu Leu 
        275                 280                 285             


Pro Asn Gly Gly Ser Gly Asn Ser Tyr Trp Xaa Gly Leu Ser Ser Asn 
    290                 295                 300                 


Lys Asp Trp Lys Leu Xaa Asp Asp Xaa Gln Arg Xaa Arg Xaa Tyr Ala 
305                 310                 315                 320 


Gln Ser Ser Lys Cys Asn Lys Val His Lys Xaa Trp Ser Trp Trp Xaa 
                325                 330                 335     


Leu Glu Ser Glu Ser Cys Arg Ser Ser Leu Pro Tyr Ile Cys Glu Met 
            340                 345                 350         


Xaa Ala Phe Arg Phe Pro Asp 
        355                 


<210> 5561
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<400> 5561
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Xaa Gly Phe Ser Ile Leu Val Xaa Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Xaa Xaa Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Xaa Val Xaa Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro His Ala Glu Cys His Gln Val Trp Gln His Asp Arg 
            100                 105                 110         


Gly Pro Cys Asp Ala Pro Ala Pro Glu Cys 
        115                 120         


<210> 5562
<211> 152
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<400> 5562
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Xaa Gly Phe Ser Ile Leu Val Xaa Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Xaa Xaa Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Xaa Val Xaa Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Xaa Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Xaa Lys Tyr Gly Asn Met Xaa Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Glu Val Ala Lys Ser 
145                 150         


<210> 5563
<211> 232
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<400> 5563
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Xaa Gly Phe Ser Ile Leu Val Xaa Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Xaa Xaa Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Xaa Val Xaa Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Xaa Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Xaa Lys Tyr Gly Asn Met Xaa Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Xaa Met Glu Xaa Ile 
                165                 170                 175     


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         


Met Ser Arg His Ser Leu Glu Gln Lys Pro Xaa Asp Ala Pro Pro Lys 
        195                 200                 205             


Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Xaa Lys 
    210                 215                 220                 


Gln Asp Leu Gly Pro Val Pro Met 
225                 230         


<210> 5564
<211> 296
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<400> 5564
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Xaa Gly Phe Ser Ile Leu Val Xaa Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Xaa Xaa Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Xaa Val Xaa Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Xaa Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Xaa Lys Tyr Gly Asn Met Xaa Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Xaa Met Glu Xaa Ile 
                165                 170                 175     


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         


Met Ser Arg His Ser Leu Glu Gln Lys Pro Xaa Asp Ala Pro Pro Lys 
        195                 200                 205             


Val Leu Xaa Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His 
    210                 215                 220                 


Pro Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro 
225                 230                 235                 240 


Leu Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn 
                245                 250                 255     


Gly Xaa Glu Val Pro Asn Xaa Arg Ser Arg Gly His His Asn Cys Ser 
            260                 265                 270         


Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Xaa Lys 
        275                 280                 285             


Gln Asp Leu Gly Pro Val Pro Met 
    290                 295     


<210> 5565
<211> 160
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<400> 5565
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Xaa Gly Phe Ser Ile Leu Val Xaa Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Xaa Xaa Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Xaa Val Xaa Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Xaa Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Xaa Lys Tyr Gly Asn Met Xaa Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Ser His Trp Asn Trp Arg Xaa Arg Leu Leu Gly Trp Val 
145                 150                 155                 160 


<210> 5566
<211> 52
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 5566
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Pro Cys Arg Met Pro Pro 
        35                  40                  45              


Ser Met Ala Xaa 
    50          


<210> 5567
<211> 316
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<400> 5567
Xaa Arg Ser Cys Arg Glu Asp Gln Lys Pro Val Met Asp Asp Gln Arg 
1               5                   10                  15      


Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met Leu Gly Arg Arg Pro 
            20                  25                  30          


Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala Leu Tyr Xaa Gly Phe 
        35                  40                  45              


Ser Ile Leu Val Xaa Leu Leu Leu Ala Gly Gln Ala Xaa Xaa Ala Tyr 
    50                  55                  60                  


Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys Leu Xaa Val Xaa Ser 
65                  70                  75                  80  


Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys Leu Pro Lys Pro Pro 
                85                  90                  95      


Lys Pro Val Ser Lys Met Arg Met Ala Xaa Pro Leu Leu Met Gln Ala 
            100                 105                 110         


Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met Gln Asn Ala Xaa Lys 
        115                 120                 125             


Tyr Gly Asn Met Xaa Glu Asp His Val Met His Leu Leu Gln Asn Ala 
    130                 135                 140                 


Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly Ser Phe Pro Glu Asn 
145                 150                 155                 160 


Leu Arg His Leu Lys Asn Xaa Met Glu Xaa Ile Asp Trp Lys Val Phe 
                165                 170                 175     


Glu Ser Trp Met His His Trp Leu Leu Phe Glu Met Ser Arg His Ser 
            180                 185                 190         


Leu Glu Gln Lys Pro Xaa Asp Ala Pro Pro Lys Val Leu Xaa Lys Cys 
        195                 200                 205             


Gln Glu Glu Val Ser His Ile Pro Ala Val His Pro Gly Ser Phe Arg 
    210                 215                 220                 


Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro Leu Gln Cys Tyr Gly 
225                 230                 235                 240 


Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn Gly Xaa Glu Val Pro 
                245                 250                 255     


Asn Xaa Arg Ser Arg Gly His His Asn Cys Ser Glu Ser Leu Glu Leu 
            260                 265                 270         


Glu Asp Pro Ser Ser Gly Leu Gly Val Xaa Lys Gln Asp Leu Gly Pro 
        275                 280                 285             


Gly Lys Gly Leu Ala Glu Gly His Leu Val Xaa Ser Ser Ser Ser Pro 
    290                 295                 300                 


Ala Gly Pro Ala Pro Leu Trp Ala Gly Glu Gly Val 
305                 310                 315     


<210> 5568
<211> 145
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<400> 5568
Xaa Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val Met Asp Asp 
1               5                   10                  15      


Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met Leu Gly Arg 
            20                  25                  30          


Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala Leu Tyr Xaa 
        35                  40                  45              


Gly Phe Ser Ile Leu Val Xaa Leu Leu Leu Ala Gly Gln Ala Xaa Xaa 
    50                  55                  60                  


Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys Leu Xaa Val 
65                  70                  75                  80  


Xaa Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys Leu Pro Lys 
                85                  90                  95      


Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Xaa Pro Leu Leu Met 
            100                 105                 110         


Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met Gln Asn Ala 
        115                 120                 125             


Xaa Lys Tyr Gly Asn Met Xaa Glu Asp His Val Met His Leu Leu Gln 
    130                 135                 140                 


Tyr 
145 


<210> 5569
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<400> 5569
Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Xaa Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Xaa Trp Trp Arg Val Leu His Gly Asn Tyr Xaa Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Glu Pro Pro Pro Arg Pro Phe Leu 
                85                  90                  95      


Asp Met Gly Glu Gly Xaa Lys Asn Arg Ile Ile Xaa Ala Glu Gly Ile 
            100                 105                 110         


Ile Leu Leu Phe Cys Ala Val Val Pro Gly Xaa Leu Leu Leu Phe Arg 
        115                 120                 125             


Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu Asp Ala Gly Asp Glu Tyr 
    130                 135                 140                 


Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser Met 
145                 150                 155                 160 


Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Xaa Tyr Gln Asp Val Gly 
                165                 170                 175     


Ser Leu Asn Ile Gly Asp Val Gln Leu Glu Lys Pro 
            180                 185             


<210> 5570
<211> 226
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<400> 5570
Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Xaa Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Xaa Trp Trp Arg Val Leu His Gly Asn Tyr Xaa Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Gly Xaa Leu Ile Ile Gln Asn Val 
                85                  90                  95      


Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn 
            100                 105                 110         


Glu Ser Tyr Gln Gln Ser Cys Gly Xaa Tyr Leu Arg Val Arg Gln Pro 
        115                 120                 125             


Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Xaa Lys Asn Arg Ile 
    130                 135                 140                 


Ile Xaa Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro Gly 
145                 150                 155                 160 


Xaa Leu Leu Leu Phe Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu 
                165                 170                 175     


Asp Ala Gly Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn 
            180                 185                 190         


Leu Asp Asp Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly 
        195                 200                 205             


Xaa Tyr Gln Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu 
    210                 215                 220                 


Lys Pro 
225     


<210> 5571
<211> 258
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<400> 5571
Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Xaa Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Xaa Trp Trp Arg Val Leu His Gly Asn Tyr Xaa Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Gly Xaa Leu Ile Ile Gln Asn Val 
                85                  90                  95      


Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn 
            100                 105                 110         


Glu Ser Tyr Gln Gln Ser Cys Gly Xaa Tyr Leu Arg Val Arg Arg Glu 
        115                 120                 125             


Trp Pro Ser Pro Gly Pro Tyr Ser His Cys Pro Ala Gly Asp Xaa Arg 
    130                 135                 140                 


Phe Ile Phe Glu Val Gly Ile Glu Pro Val Pro Ser Met Trp Val Ser 
145                 150                 155                 160 


Asn Arg Leu Gly Gln Arg Asp Gly His Ser Pro Leu Gln Ser Gly Val 
                165                 170                 175     


Ser Gly Gly Ser Gly Ala Leu Gln Glu Val Gly Gly Ala Arg Arg Leu 
            180                 185                 190         


Gly Arg Ala Arg Gly Ala Arg Ala Leu Ser His Xaa Xaa Ser Leu Gln 
        195                 200                 205             


Ser Arg Pro Pro Gly Pro Ser Trp Xaa Trp Gly Arg Ala Pro Arg Xaa 
    210                 215                 220                 


Glu Ser Ser Gln Pro Arg Gly Ser Ser Ser Cys Ser Ala Arg Trp Cys 
225                 230                 235                 240 


Leu Gly Arg Cys Cys Cys Ser Gly Asn Asp Gly Arg Xaa Arg Ser Ser 
                245                 250                 255     


Gly Trp 
        


<210> 5572
<211> 230
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<400> 5572
Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ala Ala Glu Pro Val Pro Ala Ala Arg Ser 
            20                  25                  30          


Glu Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp 
        35                  40                  45              


Gln Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Xaa Val Lys Met 
    50                  55                  60                  


His Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys 
65                  70                  75                  80  


Gln Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg 
                85                  90                  95      


Met Glu Glu Ser Gln Asn Glu Ser Leu Ala Xaa Leu Xaa Ile Gln Gly 
            100                 105                 110         


Ile Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn 
        115                 120                 125             


Asn Xaa Ser Glu Val Tyr Gln Gly Cys Gly Xaa Glu Leu Arg Val Met 
    130                 135                 140                 


Gly Phe Ser Xaa Leu Ala Gln Leu Lys Gln Arg Asn Xaa Leu Lys Asp 
145                 150                 155                 160 


Gly Ile Ile Met Ile Gln Xaa Leu Leu Ile Ile Leu Phe Ile Ile Val 
                165                 170                 175     


Pro Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu 
            180                 185                 190         


Glu Asp His Xaa Tyr Glu Gly Leu Asp Ile Asp Gln Xaa Ala Xaa Tyr 
        195                 200                 205             


Glu Asp Ile Val Xaa Leu Arg Xaa Gly Glu Val Lys Trp Ser Val Gly 
    210                 215                 220                 


Glu His Pro Gly Gln Glu 
225                 230 


<210> 5573
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 5573
Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu 
            20                  25                  30          


Asp Arg Tyr Arg Asn Pro Lys Gly Phe Ser Xaa Leu Ala Gln Leu Lys 
        35                  40                  45              


Gln Arg Asn Xaa Leu Lys Asp Gly Ile Ile Met Ile Gln Xaa Leu Leu 
    50                  55                  60                  


Ile Ile Leu Phe Ile Ile Val Pro Ile Phe Leu Leu Leu Asp Lys Asp 
65                  70                  75                  80  


Asp Ser Lys Ala Gly Met Glu Glu Asp His Xaa Tyr Glu Gly Leu Asp 
                85                  90                  95      


Ile Asp Gln Xaa Ala Xaa Tyr Glu Asp Ile Val Xaa Leu Arg Xaa Gly 
            100                 105                 110         


Glu Val Lys Trp Ser Val Gly Glu His Pro Gly Gln Glu 
        115                 120                 125 


<210> 5574
<211> 229
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<400> 5574
Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu 
            20                  25                  30          


Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp Gln 
        35                  40                  45              


Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Xaa Val Lys Met His 
    50                  55                  60                  


Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys Gln 
65                  70                  75                  80  


Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg Met 
                85                  90                  95      


Glu Glu Ser Gln Asn Glu Ser Leu Ala Xaa Leu Xaa Ile Gln Gly Ile 
            100                 105                 110         


Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn Asn 
        115                 120                 125             


Xaa Ser Glu Val Tyr Gln Gly Cys Gly Xaa Glu Leu Arg Val Met Gly 
    130                 135                 140                 


Phe Ser Xaa Leu Ala Gln Leu Lys Gln Arg Asn Xaa Leu Lys Asp Gly 
145                 150                 155                 160 


Ile Ile Met Ile Gln Xaa Leu Leu Ile Ile Leu Phe Ile Ile Val Pro 
                165                 170                 175     


Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu 
            180                 185                 190         


Asp His Xaa Tyr Glu Gly Leu Asp Ile Asp Gln Xaa Ala Xaa Tyr Glu 
        195                 200                 205             


Asp Ile Val Xaa Leu Arg Xaa Gly Glu Val Lys Trp Ser Val Gly Glu 
    210                 215                 220                 


His Pro Gly Gln Glu 
225                 


<210> 5575
<211> 256
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<400> 5575
Met Gly His Xaa Arg Arg Gln Gly Xaa Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Xaa Lys Glu Val Lys Glu Val Ala Xaa Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Xaa Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Xaa Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Xaa Ile Phe Asp Ile Xaa 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Xaa Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Xaa Leu Ser Val Lys Ala Asp Phe Pro Xaa 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Xaa Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Xaa Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Xaa Xaa Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Xaa Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Xaa Xaa Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Xaa Phe Asn Trp Asn Xaa Ser Phe Ala Pro Arg Cys Arg 
225                 230                 235                 240 


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
                245                 250                 255     


<210> 5576
<211> 288
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<400> 5576
Met Gly His Xaa Arg Arg Gln Gly Xaa Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Xaa Lys Glu Val Lys Glu Val Ala Xaa Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Xaa Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Xaa Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Xaa Ile Phe Asp Ile Xaa 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Xaa Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Xaa Leu Ser Val Lys Ala Asp Phe Pro Xaa 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Xaa Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Xaa Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Xaa Xaa Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Xaa Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Xaa Xaa Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Xaa Phe Asn Trp Asn Xaa Xaa Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Xaa Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Xaa Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210> 5577
<211> 225
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(156)
<223> Selenocysteine

<400> 5577
Gly Gly Ser Arg Trp Gln Arg Gly Phe Pro Gln Leu Ala Gly Gly Val 
1               5                   10                  15      


Ile Leu Gly Val Ala Leu Trp Leu Arg His Asp Pro Gln Xaa Xaa Asn 
            20                  25                  30          


Leu Leu Tyr Leu Glu Leu Gly Asp Lys Pro Ala Pro Asn Xaa Phe Tyr 
        35                  40                  45              


Val Gly Ile Tyr Ile Leu Ile Ala Val Gly Ala Val Met Met Phe Val 
    50                  55                  60                  


Gly Phe Leu Gly Cys Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu 
65                  70                  75                  80  


Gly Xaa Phe Phe Xaa Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala 
                85                  90                  95      


Ala Gly Ile Trp Gly Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val 
            100                 105                 110         


Lys Gln Phe Tyr Asp Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp 
        115                 120                 125             


Ala Asn Asn Ala Lys Ala Val Val Lys Xaa Phe His Glu Xaa Leu Asp 
    130                 135                 140                 


Cys Cys Gly Ser Ser Xaa Leu Xaa Ala Leu Xaa Xaa Ser Val Leu Lys 
145                 150                 155                 160 


Asn Asn Leu Cys Pro Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys 
                165                 170                 175     


Glu Asp Cys His Gln Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr 
            180                 185                 190         


Leu Ile Gly Ile Ala Ala Ile Val Val Ala Val Ile Met Ile Phe Glu 
        195                 200                 205             


Met Ile Leu Ser Met Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val 
    210                 215                 220                 


Tyr 
225 


<210> 5578
<211> 209
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(160)
<223> Selenocysteine

<400> 5578
Met Ala Pro Phe Val His Ala Arg Ala Gly Lys Xaa Lys Ala Gln Leu 
1               5                   10                  15      


Ala Gly Gly Val Ile Leu Gly Val Ala Leu Trp Leu Arg His Asp Pro 
            20                  25                  30          


Gln Xaa Xaa Asn Leu Leu Tyr Leu Glu Leu Gly Asp Lys Pro Ala Pro 
        35                  40                  45              


Asn Xaa Phe Tyr Val Gly Ile Tyr Ile Leu Ile Ala Val Gly Ala Val 
    50                  55                  60                  


Met Met Phe Val Gly Phe Leu Gly Cys Tyr Gly Ala Ile Gln Glu Ser 
65                  70                  75                  80  


Gln Cys Leu Leu Gly Xaa Phe Phe Xaa Cys Leu Val Ile Leu Phe Ala 
                85                  90                  95      


Cys Glu Val Ala Ala Gly Ile Trp Gly Phe Val Asn Lys Asp Gln Ile 
            100                 105                 110         


Ala Lys Asp Val Lys Gln Phe Tyr Asp Gln Ala Leu Gln Gln Ala Val 
        115                 120                 125             


Val Asp Asp Asp Ala Asn Asn Ala Lys Ala Val Val Lys Xaa Phe His 
    130                 135                 140                 


Glu Xaa Leu Asp Cys Cys Gly Ser Ser Xaa Leu Xaa Ala Leu Xaa Xaa 
145                 150                 155                 160 


Ser Val Leu Lys Asn Asn Leu Cys Pro Ser Gly Ser Asn Ile Ile Ser 
                165                 170                 175     


Asn Leu Phe Lys Glu Asp Cys His Gln Lys Ile Asp Asp Leu Phe Ser 
            180                 185                 190         


Gly Lys Leu Tyr Leu Ile Gly Ile Ala Ala Ile Val Val Ala Val Ile 
        195                 200                 205             


Met 
    


<210> 5579
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 5579
Met Cys Lys Pro Ala Xaa Asp Pro Arg Phe Xaa Arg Ser Pro Leu Ala 
1               5                   10                  15      


Gly Gly Val Ile Leu Gly Val Ala Leu Trp Leu Arg His Asp Pro Gln 
            20                  25                  30          


Xaa Xaa Asn Leu Leu Tyr Leu Glu Leu Gly Asp Lys Pro Ala Pro Asn 
        35                  40                  45              


Xaa Phe Tyr Val Gly Ile Tyr Ile Leu Ile Ala Val Gly Ala Val Met 
    50                  55                  60                  


Met Phe Val Gly Phe Leu Gly Cys Tyr Gly Ala Ile Gln Glu Ser Gln 
65                  70                  75                  80  


Cys Leu Leu Gly Xaa Phe Phe Xaa Cys Leu Val Ile Leu Phe Ala Cys 
                85                  90                  95      


Glu Val Ala 
            


<210> 5580
<211> 242
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(173)
<223> Selenocysteine

<400> 5580
Met Glu Glu Val Xaa Glu Ala Gln Lys Xaa His Gln Ala Arg Leu Gly 
1               5                   10                  15      


Cys Glu Val Pro Cys Cys Ser Ser Leu Ala Val Ser Asn Pro Xaa Ser 
            20                  25                  30          


Ser Gln Leu Gly Gly Pro Trp Trp Val Arg His Pro Gly Pro Ser Gly 
        35                  40                  45              


Val Leu Gly Cys Gly Glu Cys Val Gly Xaa His Leu Val Ser Leu Ser 
    50                  55                  60                  


Pro Gln Gly Ile Tyr Ile Leu Ile Ala Val Gly Ala Val Met Met Phe 
65                  70                  75                  80  


Val Gly Phe Leu Gly Cys Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu 
                85                  90                  95      


Leu Gly Xaa Phe Phe Xaa Cys Leu Val Ile Leu Phe Ala Cys Glu Val 
            100                 105                 110         


Ala Ala Gly Ile Trp Gly Phe Val Asn Lys Asp Gln Ile Ala Lys Asp 
        115                 120                 125             


Val Lys Gln Phe Tyr Asp Gln Ala Leu Gln Gln Ala Val Val Asp Asp 
    130                 135                 140                 


Asp Ala Asn Asn Ala Lys Ala Val Val Lys Xaa Phe His Glu Xaa Leu 
145                 150                 155                 160 


Asp Cys Cys Gly Ser Ser Xaa Leu Xaa Ala Leu Xaa Xaa Ser Val Leu 
                165                 170                 175     


Lys Asn Asn Leu Cys Pro Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe 
            180                 185                 190         


Lys Glu Asp Cys His Gln Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu 
        195                 200                 205             


Tyr Leu Ile Gly Ile Ala Ala Ile Val Val Ala Val Ile Met Ile Phe 
    210                 215                 220                 


Glu Met Ile Leu Ser Met Val Leu Cys Cys Gly Ile Arg Asn Ser Ser 
225                 230                 235                 240 


Val Tyr 
        


<210> 5581
<211> 236
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(167)
<223> Selenocysteine

<400> 5581
Met Gly Val Glu Gly Cys Xaa Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Xaa Xaa Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Xaa Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Xaa Phe Phe Xaa 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Xaa Phe His Glu Xaa Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Xaa Leu Xaa Ala Leu Xaa Xaa Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr 
225                 230                 235     


<210> 5582
<211> 52
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<400> 5582
Met Met Phe Val Gly Phe Leu Gly Cys Tyr Gly Ala Ile Gln Glu Ser 
1               5                   10                  15      


Gln Cys Leu Leu Gly Xaa Phe Phe Xaa Cys Leu Val Ile Leu Phe Ala 
            20                  25                  30          


Cys Glu Val Ala Ala Gly Ile Trp Gly Phe Val Asn Lys Asp Gln Ile 
        35                  40                  45              


Ala Lys Asp Val 
    50          


<210> 5583
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 5583
Met Met Phe Val Gly Phe Leu Gly Cys Tyr Gly Ala Ile Gln Glu Ser 
1               5                   10                  15      


Gln Cys Leu Leu Gly Xaa Phe Phe Xaa Cys Leu Val Ile Leu Phe Ala 
            20                  25                  30          


Cys Glu Val Ala Ala Gly Ile Trp Gly Phe Val Asn Lys Asp Gln Ile 
        35                  40                  45              


Ala Lys Asp Val Lys Gln Phe Tyr Asp Gln Ala Leu Gln Gln Ala Val 
    50                  55                  60                  


Val Asp Asp Asp Ala Asn Asn Ala Lys Ala Val Val Lys Xaa Phe His 
65                  70                  75                  80  


Glu Xaa Leu Asp Cys Cys Gly Ser Ser Xaa Leu Xaa Ala 
                85                  90              


<210> 5584
<211> 165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<400> 5584
Met Met Phe Val Gly Phe Leu Gly Cys Tyr Gly Ala Ile Gln Glu Ser 
1               5                   10                  15      


Gln Cys Leu Leu Gly Xaa Phe Phe Xaa Cys Leu Val Ile Leu Phe Ala 
            20                  25                  30          


Cys Glu Val Ala Ala Gly Ile Trp Gly Phe Val Asn Lys Asp Gln Ile 
        35                  40                  45              


Ala Lys Asp Val Lys Gln Phe Tyr Asp Gln Ala Leu Gln Gln Ala Val 
    50                  55                  60                  


Val Asp Asp Asp Ala Asn Asn Ala Lys Ala Val Val Lys Xaa Phe His 
65                  70                  75                  80  


Glu Xaa Leu Asp Cys Cys Gly Ser Ser Xaa Leu Xaa Ala Leu Xaa Xaa 
                85                  90                  95      


Ser Val Leu Lys Asn Asn Leu Cys Pro Ser Gly Ser Asn Ile Ile Ser 
            100                 105                 110         


Asn Leu Phe Lys Glu Asp Cys His Gln Lys Ile Asp Asp Leu Phe Ser 
        115                 120                 125             


Gly Lys Leu Tyr Leu Ile Gly Ile Ala Ala Ile Val Val Ala Val Ile 
    130                 135                 140                 


Met Ile Phe Glu Met Ile Leu Ser Met Val Leu Cys Cys Gly Ile Arg 
145                 150                 155                 160 


Asn Ser Ser Val Tyr 
                165 


<210> 5585
<211> 274
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(205)
<223> Selenocysteine

<400> 5585
Met Trp Cys Gly Trp Ser Phe Ser Trp Gln Pro Val His Trp Val Arg 
1               5                   10                  15      


Ser Ala Cys Gly Cys Ser Leu Xaa Trp Val Ser Trp Ser Leu Ala Ser 
            20                  25                  30          


Ser Ser Ser Arg Ser Leu Leu Lys Val Gly Glu Leu Gly Met Ala Pro 
        35                  40                  45              


Phe Val His Ala Arg Ala Gly Lys Xaa Lys Ala Gln Leu Ala Gly Gly 
    50                  55                  60                  


Val Ile Leu Gly Val Ala Leu Trp Leu Arg His Asp Pro Gln Xaa Xaa 
65                  70                  75                  80  


Asn Leu Leu Tyr Leu Glu Leu Gly Asp Lys Pro Ala Pro Asn Xaa Phe 
                85                  90                  95      


Tyr Val Gly Ile Tyr Ile Leu Ile Ala Val Gly Ala Val Met Met Phe 
            100                 105                 110         


Val Gly Phe Leu Gly Cys Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu 
        115                 120                 125             


Leu Gly Xaa Phe Phe Xaa Cys Leu Val Ile Leu Phe Ala Cys Glu Val 
    130                 135                 140                 


Ala Ala Gly Ile Trp Gly Phe Val Asn Lys Asp Gln Ile Ala Lys Asp 
145                 150                 155                 160 


Val Lys Gln Phe Tyr Asp Gln Ala Leu Gln Gln Ala Val Val Asp Asp 
                165                 170                 175     


Asp Ala Asn Asn Ala Lys Ala Val Val Lys Xaa Phe His Glu Xaa Leu 
            180                 185                 190         


Asp Cys Cys Gly Ser Ser Xaa Leu Xaa Ala Leu Xaa Xaa Ser Val Leu 
        195                 200                 205             


Lys Asn Asn Leu Cys Pro Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe 
    210                 215                 220                 


Lys Glu Asp Cys His Gln Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu 
225                 230                 235                 240 


Tyr Leu Ile Gly Ile Ala Ala Ile Val Val Ala Val Ile Met Ile Phe 
                245                 250                 255     


Glu Met Ile Leu Ser Met Val Leu Cys Cys Gly Ile Arg Asn Ser Ser 
            260                 265                 270         


Val Tyr 
        


<210> 5586
<211> 148
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 5586
Gln Xaa Gln Asp Val Pro Leu Pro Ala Pro Glu Ala Pro Ser Pro Asp 
1               5                   10                  15      


Glu Leu Ala Gly Gly Val Ile Leu Gly Val Ala Leu Trp Leu Arg His 
            20                  25                  30          


Asp Pro Gln Xaa Xaa Asn Leu Leu Tyr Leu Glu Leu Gly Asp Lys Pro 
        35                  40                  45              


Ala Pro Asn Xaa Phe Tyr Val Gly Ile Tyr Ile Leu Ile Ala Val Gly 
    50                  55                  60                  


Ala Val Met Met Phe Val Gly Phe Leu Gly Cys Tyr Gly Ala Ile Gln 
65                  70                  75                  80  


Glu Ser Gln Cys Leu Leu Gly Xaa Phe Phe Xaa Cys Leu Val Ile Leu 
                85                  90                  95      


Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly Phe Val Asn Lys Asp 
            100                 105                 110         


Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp Gln Ala Leu Gln Gln 
        115                 120                 125             


Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys Ala Val Val Lys Xaa 
    130                 135                 140                 


Phe His Glu Xaa 
145             


<210> 5587
<211> 221
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (26)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(152)
<223> Selenocysteine

<400> 5587
Xaa Gln Arg Gly Phe Pro Gln Leu Ala Gly Gly Val Ile Leu Gly Val 
1               5                   10                  15      


Ala Leu Trp Leu Arg His Asp Pro Gln Xaa Xaa Asn Leu Leu Tyr Leu 
            20                  25                  30          


Glu Leu Gly Asp Lys Pro Ala Pro Asn Xaa Phe Tyr Val Gly Ile Tyr 
        35                  40                  45              


Ile Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly 
    50                  55                  60                  


Cys Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Xaa Phe Phe 
65                  70                  75                  80  


Xaa Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp 
                85                  90                  95      


Gly Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr 
            100                 105                 110         


Asp Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala 
        115                 120                 125             


Lys Ala Val Val Lys Xaa Phe His Glu Xaa Leu Asp Cys Cys Gly Ser 
    130                 135                 140                 


Ser Xaa Leu Xaa Ala Leu Xaa Xaa Ser Val Leu Lys Asn Asn Leu Cys 
145                 150                 155                 160 


Pro Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His 
                165                 170                 175     


Gln Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile 
            180                 185                 190         


Ala Ala Ile Val Val Ala Val Ile Met Val Ser Gly Arg Gly Arg Arg 
        195                 200                 205             


Ala Cys Ser Leu Gly Cys Pro Phe Arg Gly Ala Leu Cys 
    210                 215                 220     


<210> 5588
<211> 57
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<400> 5588
Asp Asn Ser Leu Ser Val Arg Lys Gly Phe Cys Glu Ala Pro Gly Asn 
1               5                   10                  15      


Arg Xaa Gln Ser Gly Asn His Pro Glu Asp Trp Pro Val Tyr Gln Glu 
            20                  25                  30          


Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val His Ser 
        35                  40                  45              


Glu Asp Tyr Ser Lys Val Pro Lys Tyr 
    50                  55          


<210> 5589
<211> 179
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 5589
Met Ala Arg Asp Trp Ile Arg Pro Gln Arg Ala Ser Asp Cys Trp Ser 
1               5                   10                  15      


Gly Lys Gln Gln Leu Phe Gln Ile Ile Ile Ile Ile Ile Ile Ser Pro 
            20                  25                  30          


Pro Cys Cys Cys Val Asp Asp Xaa Trp Ala Gln Ala Glu Val Gly Pro 
        35                  40                  45              


Val Xaa Ser Cys Xaa Gly Phe Val Glu Gly Ser Ser Arg Xaa Gly Gly 
    50                  55                  60                  


Met Gly Ser Ala Cys Ile Lys Val Xaa Lys Tyr Phe Leu Phe Leu Phe 
65                  70                  75                  80  


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
                85                  90                  95      


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Xaa Ser 
            100                 105                 110         


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
        115                 120                 125             


Val Xaa Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
    130                 135                 140                 


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
145                 150                 155                 160 


Ile Ala Gln Val Xaa Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
                165                 170                 175     


Val Ser Pro 
            


<210> 5590
<211> 157
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<400> 5590
Met Glu Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val Trp Ile Leu 
1               5                   10                  15      


Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Xaa Ser Ser Ser Ser 
            20                  25                  30          


Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala Val Xaa Met 
        35                  40                  45              


Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu Val Arg Cys 
    50                  55                  60                  


Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu Ile Ala Gln 
65                  70                  75                  80  


Val Xaa Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys Leu Lys Gln 
                85                  90                  95      


Glu Met Gly Gly Ile Val Xaa Glu Leu Ile Arg Asp Tyr Asn Ser Ser 
            100                 105                 110         


Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln Ala Gln Val 
        115                 120                 125             


Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Xaa Asp Asn Ala Glu 
    130                 135                 140                 


Leu Met Asn Arg Pro Glu Val Xaa Tyr Pro Cys Ser Cys 
145                 150                 155         


<210> 5591
<211> 38
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<400> 5591
Met Gly Ser Ala Cys Ile Lys Val Xaa Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys 
        35              


<210> 5592
<211> 68
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 5592
Met Gly Ser Ala Cys Ile Lys Val Xaa Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Xaa Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Xaa Met Leu 
65              


<210> 5593
<211> 242
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<400> 5593
Met Gly Ser Ala Cys Ile Lys Val Xaa Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Xaa Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Xaa Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Leu Lys Gln Glu Met Gly Gly Ile Val 
                85                  90                  95      


Xaa Glu Leu Ile Arg Asp Tyr Asn Ser Ser Arg Glu Asp Ser Leu Gln 
            100                 105                 110         


Asp Ala Trp Asp Tyr Val Gln Ala Gln Val Lys Cys Cys Gly Trp Val 
        115                 120                 125             


Ser Phe Tyr Asn Trp Xaa Asp Asn Ala Glu Leu Met Asn Arg Pro Glu 
    130                 135                 140                 


Val Xaa Tyr Pro Cys Ser Cys Glu Val Lys Gly Glu Glu Asp Asn Ser 
145                 150                 155                 160 


Leu Ser Val Arg Lys Gly Phe Cys Glu Ala Pro Gly Asn Arg Xaa Gln 
                165                 170                 175     


Ser Gly Asn His Pro Glu Asp Trp Pro Val Tyr Gln Glu Gly Cys Met 
            180                 185                 190         


Glu Lys Val Gln Ala Trp Leu Gln Glu Asn Leu Gly Ile Ile Leu Gly 
        195                 200                 205             


Val Gly Val Gly Val Ala Ile Ile Glu Leu Leu Gly Met Val Leu Ser 
    210                 215                 220                 


Ile Cys Leu Cys Arg His Val His Ser Glu Asp Tyr Ser Lys Val Pro 
225                 230                 235                 240 


Lys Tyr 
        


<210> 5594
<211> 105
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<400> 5594
Met Gly Ser Ala Cys Ile Lys Val Xaa Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Xaa Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Xaa Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                85                  90                  95      


Ile Ala Gln Val Xaa Ala Gly Ala Leu 
            100                 105 


<210> 5595
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<400> 5595
Met Gly Ser Ala Cys Ile Lys Val Xaa Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Xaa Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Xaa Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                85                  90                  95      


Ile Ala Gln Val Xaa Ala Gly Ala Leu Phe Tyr Phe 
            100                 105             


<210> 5596
<211> 267
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<400> 5596
Met Gly Ser Ala Cys Ile Lys Val Xaa Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Xaa Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Xaa Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                85                  90                  95      


Ile Ala Gln Val Xaa Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
            100                 105                 110         


Leu Lys Gln Glu Met Gly Gly Ile Val Xaa Glu Leu Ile Arg Asp Tyr 
        115                 120                 125             


Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln 
    130                 135                 140                 


Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Xaa Asp 
145                 150                 155                 160 


Asn Ala Glu Leu Met Asn Arg Pro Glu Val Xaa Tyr Pro Cys Ser Cys 
                165                 170                 175     


Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe 
            180                 185                 190         


Cys Glu Ala Pro Gly Asn Arg Xaa Gln Ser Gly Asn His Pro Glu Asp 
        195                 200                 205             


Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu 
    210                 215                 220                 


Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile 
225                 230                 235                 240 


Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val 
                245                 250                 255     


His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr 
            260                 265         


<210> 5597
<211> 161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<400> 5597
Met Pro Leu Val Ile Asn Gln Ser Pro Pro Cys Cys Cys Val Asp Asp 
1               5                   10                  15      


Xaa Trp Ala Gln Ala Glu Val Gly Pro Val Xaa Ser Cys Xaa Gly Phe 
            20                  25                  30          


Val Glu Gly Ser Ser Arg Xaa Gly Gly Met Gly Ser Ala Cys Ile Lys 
        35                  40                  45              


Val Xaa Lys Tyr Phe Leu Phe Leu Phe Asn Leu Ile Phe Phe Ile Leu 
    50                  55                  60                  


Gly Ala Val Ile Leu Gly Phe Gly Val Trp Ile Leu Ala Asp Lys Ser 
65                  70                  75                  80  


Ser Phe Ile Ser Val Leu Gln Xaa Ser Ser Ser Ser Leu Arg Met Gly 
                85                  90                  95      


Ala Tyr Val Phe Ile Gly Val Gly Ala Val Xaa Met Leu Met Gly Phe 
            100                 105                 110         


Leu Gly Cys Ile Gly Ala Val Asn Glu Val Arg Cys Leu Leu Gly Leu 
        115                 120                 125             


Tyr Phe Ala Phe Leu Leu Leu Ile Leu Ile Ala Gln Val Xaa Ala Gly 
    130                 135                 140                 


Ala Leu Phe Tyr Phe Asn Met Gly Lys Leu Lys Gln Glu Met Gly Gly 
145                 150                 155                 160 


Ile 
    


<210> 5598
<211> 146
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<400> 5598
Met Glu Xaa Pro Gln Glu Asp His Leu Arg Gly Gln His Tyr His Gln 
1               5                   10                  15      


Lys Gly Gln Asn Gly Ser Phe Asp Ala Pro Asn Glu Arg Pro Tyr Ser 
            20                  25                  30          


Leu Lys Ile Arg Asn Xaa Xaa Ser Cys Asn Ser Gly Xaa Tyr Arg Cys 
        35                  40                  45              


Xaa Leu Gln Asp Pro Asp Gly Gln Arg Asn Leu Ser Gly Lys Val Ile 
    50                  55                  60                  


Leu Arg Val Xaa Gly Cys Pro Ala Gln Arg Lys Glu Glu Xaa Phe Lys 
65                  70                  75                  80  


Lys Tyr Arg Ala Glu Ile Val Leu Leu Leu Ala Leu Val Ile Phe Tyr 
                85                  90                  95      


Leu Xaa Leu Ile Ile Phe Xaa Cys Lys Phe Ala Arg Leu Gln Ser Ile 
            100                 105                 110         


Phe Pro Asp Phe Ser Lys Ala Gly Met Glu Arg Ala Phe Leu Pro Val 
        115                 120                 125             


Xaa Ser Pro Asn Lys His Leu Gly Leu Val Xaa Pro His Lys Xaa Glu 
    130                 135                 140                 


Leu Val 
145     


<210> 5599
<211> 205
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<400> 5599
Met Ser Arg Gly Leu Gln Leu Leu Leu Leu Ser Cys Ala Tyr Ser Leu 
1               5                   10                  15      


Ala Pro Ala Xaa Pro Glu Val Lys Val Ala Cys Ser Glu Asp Val Asp 
            20                  25                  30          


Leu Pro Cys Xaa Ala Pro Trp Asp Pro Gln Val Pro Tyr Xaa Val Ser 
        35                  40                  45              


Trp Val Lys Leu Leu Glu Gly Gly Glu Glu Arg Met Glu Xaa Pro Gln 
    50                  55                  60                  


Glu Asp His Leu Arg Gly Gln His Tyr His Gln Lys Gly Gln Asn Gly 
65                  70                  75                  80  


Ser Phe Asp Ala Pro Asn Glu Arg Pro Tyr Ser Leu Lys Ile Arg Asn 
                85                  90                  95      


Xaa Xaa Ser Cys Asn Ser Gly Xaa Tyr Arg Cys Xaa Leu Gln Asp Pro 
            100                 105                 110         


Asp Gly Gln Arg Asn Leu Ser Gly Lys Val Ile Leu Arg Val Xaa Gly 
        115                 120                 125             


Cys Pro Ala Gln Arg Lys Glu Glu Xaa Phe Lys Lys Tyr Arg Ala Glu 
    130                 135                 140                 


Ile Val Leu Leu Leu Ala Leu Val Ile Phe Tyr Leu Xaa Leu Ile Ile 
145                 150                 155                 160 


Phe Xaa Cys Lys Phe Ala Arg Leu Gln Ser Ile Phe Pro Asp Phe Ser 
                165                 170                 175     


Lys Ala Gly Met Glu Arg Ala Phe Leu Pro Val Xaa Ser Pro Asn Lys 
            180                 185                 190         


His Leu Gly Leu Val Xaa Pro His Lys Xaa Glu Leu Val 
        195                 200                 205 


<210> 5600
<211> 217
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<400> 5600
Met Asp Pro Gln Cys Xaa Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
            20                  25                  30          


Ser Asn Ile Xaa Glu Asn Val Tyr Ile Asn Leu Xaa Cys Ser Ser Ile 
        35                  40                  45              


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Xaa Lys 
    50                  55                  60                  


Asn Ser Xaa Ile Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn 
65                  70                  75                  80  


Val Xaa Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
                85                  90                  95      


Asp Val Xaa Ser Asn Met Xaa Ile Phe Cys Ile Leu Glu Xaa Asp Lys 
            100                 105                 110         


Xaa Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
        115                 120                 125             


Pro Pro Pro Asp His Ile Pro Trp Ile Xaa Ala Val Leu Pro Xaa Val 
    130                 135                 140                 


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
145                 150                 155                 160 


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Xaa Asn Xaa Met Glu 
                165                 170                 175     


Arg Glu Glu Ser Glu Gln Xaa Lys Lys Arg Glu Lys Ile His Ile Pro 
            180                 185                 190         


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Xaa Ser 
        195                 200                 205             


Ser Cys Asp Lys Ser Asp Xaa Cys Phe 
    210                 215         


<210> 5601
<211> 329
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<400> 5601
Met Asp Pro Gln Cys Xaa Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe 
            20                  25                  30          


Asn Glu Xaa Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val 
    50                  55                  60                  


Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser 
65                  70                  75                  80  


Lys Tyr Met Gly Arg Xaa Ser Phe Asp Ser Asp Ser Trp Xaa Leu Arg 
                85                  90                  95      


Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile 
            100                 105                 110         


His His Lys Lys Pro Xaa Gly Met Ile Arg Ile His Gln Met Asn Ser 
        115                 120                 125             


Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
    130                 135                 140                 


Ser Asn Ile Xaa Glu Asn Val Tyr Ile Asn Leu Xaa Cys Ser Ser Ile 
145                 150                 155                 160 


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Xaa Lys 
                165                 170                 175     


Asn Ser Xaa Ile Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn 
            180                 185                 190         


Val Xaa Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
        195                 200                 205             


Asp Val Xaa Ser Asn Met Xaa Ile Phe Cys Ile Leu Glu Xaa Asp Lys 
    210                 215                 220                 


Xaa Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
225                 230                 235                 240 


Pro Pro Pro Asp His Ile Pro Trp Ile Xaa Ala Val Leu Pro Xaa Val 
                245                 250                 255     


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
            260                 265                 270         


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Xaa Asn Xaa Met Glu 
        275                 280                 285             


Arg Glu Glu Ser Glu Gln Xaa Lys Lys Arg Glu Lys Ile His Ile Pro 
    290                 295                 300                 


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Xaa Ser 
305                 310                 315                 320 


Ser Cys Asp Lys Ser Asp Xaa Cys Phe 
                325                 


<210> 5602
<211> 167
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 5602
Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Xaa Ala Asp Leu 
            20                  25                  30          


Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val 
        35                  40                  45              


Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
    50                  55                  60                  


Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Xaa 
65                  70                  75                  80  


Ser Phe Asp Ser Asp Ser Trp Xaa Leu Arg Leu His Asn Leu Gln Ile 
                85                  90                  95      


Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Xaa 
            100                 105                 110         


Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
        115                 120                 125             


Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Xaa Glu Asn 
    130                 135                 140                 


Val Tyr Ile Asn Leu Xaa Cys Ser Ser Ile His Gly Tyr Pro Glu Pro 
145                 150                 155                 160 


Lys Lys Met Ser Val Leu Leu 
                165         


<210> 5603
<211> 323
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<400> 5603
Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Xaa Ala Asp Leu 
            20                  25                  30          


Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val 
        35                  40                  45              


Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
    50                  55                  60                  


Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Xaa 
65                  70                  75                  80  


Ser Phe Asp Ser Asp Ser Trp Xaa Leu Arg Leu His Asn Leu Gln Ile 
                85                  90                  95      


Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Xaa 
            100                 105                 110         


Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
        115                 120                 125             


Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Xaa Glu Asn 
    130                 135                 140                 


Val Tyr Ile Asn Leu Xaa Cys Ser Ser Ile His Gly Tyr Pro Glu Pro 
145                 150                 155                 160 


Lys Lys Met Ser Val Leu Leu Arg Xaa Lys Asn Ser Xaa Ile Glu Tyr 
                165                 170                 175     


Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Xaa Glu Leu Tyr Asp 
            180                 185                 190         


Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Xaa Ser Asn Met 
        195                 200                 205             


Xaa Ile Phe Cys Ile Leu Glu Xaa Asp Lys Xaa Arg Leu Leu Ser Ser 
    210                 215                 220                 


Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile 
225                 230                 235                 240 


Pro Trp Ile Xaa Ala Val Leu Pro Xaa Val Ile Ile Cys Val Met Val 
                245                 250                 255     


Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys Lys Lys Arg Pro Arg Asn 
            260                 265                 270         


Ser Tyr Lys Cys Gly Xaa Asn Xaa Met Glu Arg Glu Glu Ser Glu Gln 
        275                 280                 285             


Xaa Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg Ser Asp Glu Ala 
    290                 295                 300                 


Gln Arg Val Phe Lys Ser Ser Lys Xaa Ser Ser Cys Asp Lys Ser Asp 
305                 310                 315                 320 


Xaa Cys Phe 
            


<210> 5604
<211> 275
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<400> 5604
Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Xaa Ala Asp Leu 
            20                  25                  30          


Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val 
        35                  40                  45              


Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
    50                  55                  60                  


Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Xaa 
65                  70                  75                  80  


Ser Phe Asp Ser Asp Ser Trp Xaa Leu Arg Leu His Asn Leu Gln Ile 
                85                  90                  95      


Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Xaa 
            100                 105                 110         


Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
        115                 120                 125             


Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Xaa Glu Asn 
    130                 135                 140                 


Val Tyr Ile Asn Leu Xaa Cys Ser Ser Ile His Gly Tyr Pro Glu Pro 
145                 150                 155                 160 


Lys Lys Met Ser Val Leu Leu Arg Xaa Lys Asn Ser Xaa Ile Glu Tyr 
                165                 170                 175     


Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Xaa Glu Leu Tyr Asp 
            180                 185                 190         


Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Xaa Ser Asn Met 
        195                 200                 205             


Xaa Ile Phe Cys Ile Leu Glu Xaa Asp Lys Xaa Arg Leu Leu Ser Ser 
    210                 215                 220                 


Pro Phe Ser Ile Gly Xaa Asn Xaa Met Glu Arg Glu Glu Ser Glu Gln 
225                 230                 235                 240 


Xaa Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg Ser Asp Glu Ala 
                245                 250                 255     


Gln Arg Val Phe Lys Ser Ser Lys Xaa Ser Ser Cys Asp Lys Ser Asp 
            260                 265                 270         


Xaa Cys Phe 
        275 


<210> 5605
<211> 247
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<400> 5605
Met Gly Arg Xaa Ser Phe Asp Ser Asp Ser Trp Xaa Leu Arg Leu His 
1               5                   10                  15      


Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His 
            20                  25                  30          


Lys Lys Pro Xaa Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu 
        35                  40                  45              


Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn 
    50                  55                  60                  


Ile Xaa Glu Asn Val Tyr Ile Asn Leu Xaa Cys Ser Ser Ile His Gly 
65                  70                  75                  80  


Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Xaa Lys Asn Ser 
                85                  90                  95      


Xaa Ile Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Xaa 
            100                 105                 110         


Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
        115                 120                 125             


Xaa Ser Asn Met Xaa Ile Phe Cys Ile Leu Glu Xaa Asp Lys Xaa Arg 
    130                 135                 140                 


Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro 
145                 150                 155                 160 


Pro Asp His Ile Pro Trp Ile Xaa Ala Val Leu Pro Xaa Val Ile Ile 
                165                 170                 175     


Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys Lys Lys 
            180                 185                 190         


Arg Pro Arg Asn Ser Tyr Lys Cys Gly Xaa Asn Xaa Met Glu Arg Glu 
        195                 200                 205             


Glu Ser Glu Gln Xaa Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg 
    210                 215                 220                 


Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Xaa Ser Ser Cys 
225                 230                 235                 240 


Asp Lys Ser Asp Xaa Cys Phe 
                245         


<210> 5606
<211> 277
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<400> 5606
Xaa Xaa Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu 
1               5                   10                  15      


Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Xaa Ala 
            20                  25                  30          


Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu 
        35                  40                  45              


Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val 
    50                  55                  60                  


Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly 
65                  70                  75                  80  


Arg Xaa Ser Phe Asp Ser Asp Ser Trp Xaa Leu Arg Leu His Asn Leu 
                85                  90                  95      


Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys 
            100                 105                 110         


Pro Xaa Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val 
        115                 120                 125             


Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Xaa 
    130                 135                 140                 


Glu Asn Val Tyr Ile Asn Leu Xaa Cys Ser Ser Ile His Gly Tyr Pro 
145                 150                 155                 160 


Glu Pro Lys Lys Met Ser Val Leu Leu Arg Xaa Lys Asn Ser Xaa Ile 
                165                 170                 175     


Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Xaa Glu Leu 
            180                 185                 190         


Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Xaa Ser 
        195                 200                 205             


Asn Met Xaa Ile Phe Cys Ile Leu Glu Xaa Asp Lys Xaa Arg Leu Leu 
    210                 215                 220                 


Ser Ser Pro Phe Ser Ile Gly Xaa Asn Xaa Met Glu Arg Glu Glu Ser 
225                 230                 235                 240 


Glu Gln Xaa Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg Ser Asp 
                245                 250                 255     


Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Xaa Ser Ser Cys Asp Lys 
            260                 265                 270         


Ser Asp Xaa Cys Phe 
        275         


<210> 5607
<211> 198
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<400> 5607
Met Ala Leu Pro Val Xaa Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Xaa 
            20                  25                  30          


Trp Asn Leu Gly Glu Xaa Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Xaa Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Xaa Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Xaa Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Xaa Phe Val Leu Xaa Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Xaa Xaa Xaa Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Xaa Pro Ala Pro Xaa Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Gly Asn Arg Arg Arg 
                165                 170                 175     


Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser 
            180                 185                 190         


Leu Ser Ala Arg Tyr Val 
        195             


<210> 5608
<211> 235
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<400> 5608
Met Ala Leu Pro Val Xaa Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Xaa 
            20                  25                  30          


Trp Asn Leu Gly Glu Xaa Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Xaa Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Xaa Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Xaa Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Xaa Phe Val Leu Xaa Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Xaa Xaa Xaa Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Xaa Pro Ala Pro Xaa Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Xaa Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Xaa 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Xaa Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210> 5609
<211> 198
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 5609
Met Ala Leu Pro Val Xaa Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Xaa 
            20                  25                  30          


Trp Asn Leu Gly Glu Xaa Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Xaa Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Xaa Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Xaa Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Xaa Phe Val Leu Xaa Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Val His Xaa Arg Gly Leu Asp Phe Ala Cys 
    130                 135                 140                 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Xaa Cys Gly Val Leu Leu 
145                 150                 155                 160 


Leu Ser Leu Val Ile Xaa Leu Tyr Cys Asn His Arg Asn Arg Arg Arg 
                165                 170                 175     


Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser 
            180                 185                 190         


Leu Ser Ala Arg Tyr Val 
        195             


<210> 5610
<211> 198
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<400> 5610
Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Xaa Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Xaa Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Xaa Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Xaa Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Xaa Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Xaa Phe Gly Lys 
        115                 120                 125             


Gly Xaa Gln Leu Ser Val Val Asp Phe Leu Pro Xaa Xaa Ala Gln Pro 
    130                 135                 140                 


Xaa Lys Lys Ser Xaa Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Xaa Gln Lys Gly Leu Lys Gly Lys Val Tyr Gln Glu Pro Leu Ser 
                165                 170                 175     


Pro Asn Ala Cys Met Asp Xaa Xaa Ala Ile Leu Gln Pro His Arg Ser 
            180                 185                 190         


Cys Leu Xaa His Gly Ser 
        195             


<210> 5611
<211> 210
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<400> 5611
Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Xaa Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Xaa Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Xaa Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Xaa Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Xaa Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Xaa Phe Gly Lys 
        115                 120                 125             


Gly Xaa Gln Leu Ser Val Val Asp Phe Leu Pro Xaa Xaa Ala Gln Pro 
    130                 135                 140                 


Xaa Lys Lys Ser Xaa Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Xaa Gln Lys Gly Pro Leu Cys Ser Pro Ile Xaa Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe 
        195                 200                 205             


Tyr Lys 
    210 


<210> 5612
<211> 221
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<400> 5612
Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Xaa Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Xaa Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Xaa Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Xaa Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Xaa Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Xaa Phe Gly Lys 
        115                 120                 125             


Gly Xaa Gln Leu Ser Val Val Asp Phe Leu Pro Xaa Xaa Ala Gln Pro 
    130                 135                 140                 


Xaa Lys Lys Ser Xaa Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Xaa Gln Lys Gly Pro Leu Cys Ser Pro Ile Xaa Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Leu 
        195                 200                 205             


Arg Leu His Pro Leu Glu Lys Cys Ser Arg Met Asp Tyr 
    210                 215                 220     


<210> 5613
<211> 210
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<400> 5613
Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Xaa Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Xaa Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Xaa Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Xaa Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Xaa Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Xaa Phe Gly Lys 
        115                 120                 125             


Gly Xaa Gln Leu Ser Val Val Asp Phe Leu Pro Xaa Xaa Ala Gln Pro 
    130                 135                 140                 


Xaa Lys Lys Ser Xaa Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Xaa Gln Lys Gly Pro Leu Cys Ser Pro Ile Xaa Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Leu 
        195                 200                 205             


Tyr Lys 
    210 


<210> 5614
<211> 243
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<400> 5614
Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Xaa Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Xaa Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Xaa Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Xaa Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Xaa Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Xaa Phe Gly Lys 
        115                 120                 125             


Gly Xaa Gln Leu Ser Val Val Asp Phe Leu Pro Xaa Xaa Ala Gln Pro 
    130                 135                 140                 


Xaa Lys Lys Ser Xaa Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Xaa Gln Lys Gly Pro Leu Cys Ser Pro Ile Xaa Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Pro 
        195                 200                 205             


Gln Gly Glu Gly Ile Ser Gly Xaa Phe Val Pro Gln Cys Leu His Gly 
    210                 215                 220                 


Tyr Tyr Ser Asn Xaa Xaa Xaa Ser Gln Lys Leu Leu Asn Pro Trp Ile 
225                 230                 235                 240 


Leu Lys Xaa 
            


<210> 5615
<211> 213
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<400> 5615
Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Xaa Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Xaa Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Xaa Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Xaa Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Xaa Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Xaa Phe Gly Lys 
        115                 120                 125             


Gly Xaa Gln Leu Ser Val Val Asp Phe Leu Pro Xaa Xaa Ala Gln Pro 
    130                 135                 140                 


Xaa Lys Lys Ser Xaa Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Xaa Gln Lys Gly Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys 
                165                 170                 175     


Gln Pro Gln Gly Glu Gly Ile Ser Gly Xaa Phe Val Pro Gln Cys Leu 
            180                 185                 190         


His Gly Tyr Tyr Ser Asn Xaa Xaa Xaa Ser Gln Lys Leu Leu Asn Pro 
        195                 200                 205             


Trp Ile Leu Lys Xaa 
    210             


<210> 5616
<211> 159
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<400> 5616
Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly Ala Val Gln Glu Ser 
1               5                   10                  15      


Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu Leu Val Ile Phe Ala 
            20                  25                  30          


Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser His Lys Asp Glu Val 
        35                  40                  45              


Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Xaa Tyr Asn Lys Leu Lys 
    50                  55                  60                  


Xaa Lys Asp Glu Pro Gln Arg Glu Xaa Leu Lys Ala Ile His Tyr Ala 
65                  70                  75                  80  


Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu Gln Phe Ile Ser Asp 
                85                  90                  95      


Ile Cys Pro Lys Lys Asp Val Leu Glu Xaa Phe Xaa Val Lys Ser Cys 
            100                 105                 110         


Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys Phe His Ile Ile Gly 
        115                 120                 125             


Ala Val Gly Ile Gly Ile Ala Val Val Met Ile Phe Gly Met Ile Phe 
    130                 135                 140                 


Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn Arg Glu Met Val 
145                 150                 155                 


<210> 5617
<211> 228
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<400> 5617
Met Pro Val Lys Gly Gly Xaa Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Xaa Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Xaa Asn Asn Asn Asn Ser Ser Phe Tyr Xaa Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Ala Xaa Lys Arg Xaa 
                85                  90                  95      


Met Phe Pro Pro Phe Leu Glu Asp His Val Cys Phe Phe Ser Leu Asn 
            100                 105                 110         


Pro Gln Phe Phe Gly Phe Leu Leu Val Ile Phe Ala Ile Glu Ile Ala 
        115                 120                 125             


Ala Ala Ile Trp Gly Tyr Ser His Lys Asp Glu Val Ile Lys Glu Val 
    130                 135                 140                 


Gln Glu Phe Tyr Lys Asp Xaa Tyr Asn Lys Leu Lys Xaa Lys Asp Glu 
145                 150                 155                 160 


Pro Gln Arg Glu Xaa Leu Lys Ala Ile His Tyr Ala Leu Asn Cys Cys 
                165                 170                 175     


Gly Leu Ala Gly Gly Val Glu Gln Phe Ile Ser Asp Ile Cys Pro Lys 
            180                 185                 190         


Lys Asp Val Leu Glu Xaa Phe Xaa Val Lys Ser Cys Pro Asp Ala Ile 
        195                 200                 205             


Lys Glu Val Phe Asp Asn Lys Phe His Ile Ile Gly Ala Val Gly Ile 
    210                 215                 220                 


Gly Ile Ala Val 
225             


<210> 5618
<211> 142
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<400> 5618
Met Pro Val Lys Gly Gly Xaa Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Xaa Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Xaa Asn Asn Asn Asn Ser Ser Phe Tyr Xaa Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Xaa 
        115                 120                 125             


Tyr Asn Lys Leu Lys Xaa Lys Asp Glu Pro Gln Arg Glu Xaa 
    130                 135                 140         


<210> 5619
<211> 228
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<400> 5619
Met Pro Val Lys Gly Gly Xaa Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Xaa Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Xaa Asn Asn Asn Asn Ser Ser Phe Tyr Xaa Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Xaa 
        115                 120                 125             


Tyr Asn Lys Leu Lys Xaa Lys Asp Glu Pro Gln Arg Glu Xaa Leu Lys 
    130                 135                 140                 


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
145                 150                 155                 160 


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Xaa Phe 
                165                 170                 175     


Xaa Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
            180                 185                 190         


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
        195                 200                 205             


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
    210                 215                 220                 


Arg Glu Met Val 
225             


<210> 5620
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 5620
Met Pro Val Lys Gly Gly Xaa Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Xaa Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Xaa Asn Asn Asn Asn Ser Ser Phe Tyr Xaa Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Xaa 
        115                 120                 125             


Tyr Asn Lys Leu Lys Xaa Lys Asp Glu Pro Gln Arg Glu Xaa Leu Lys 
    130                 135                 140                 


Ala Ile His Tyr Ala Val Glu Leu Leu Trp Phe Gly Trp Gly Arg Gly 
145                 150                 155                 160 


Xaa Val Tyr Leu Arg His Leu Pro Gln Glu Gly Arg Xaa Arg Asn Leu 
                165                 170                 175     


His Arg Glu Val Leu Ser 
            180         


<210> 5621
<211> 146
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<400> 5621
Met Ala Gln Lys Arg Pro Ala Cys Xaa Leu Lys Pro Glu Cys Val Gln 
1               5                   10                  15      


Gln Leu Leu Val Cys Ser Gln Glu Ala Lys Lys Ser Ala Tyr Cys Pro 
            20                  25                  30          


Tyr Ser His Phe Pro Val Gly Ala Ala Leu Leu Xaa Gln Glu Gly Arg 
        35                  40                  45              


Ile Phe Lys Gly Cys Asn Ile Glu Asn Ala Cys Tyr Pro Leu Gly Ile 
    50                  55                  60                  


Cys Ala Glu Arg Xaa Ala Ile Gln Lys Ala Val Ser Glu Gly Tyr Lys 
65                  70                  75                  80  


Asp Phe Arg Ala Ile Ala Ile Ala Ser Asp Met Gln Asp Asp Phe Ile 
                85                  90                  95      


Ser Pro Cys Gly Ala Cys Arg Gln Val Met Arg Glu Phe Gly Xaa Asn 
            100                 105                 110         


Trp Pro Val Tyr Met Xaa Lys Pro Asp Gly Xaa Tyr Ile Val Met Xaa 
        115                 120                 125             


Val Gln Glu Leu Leu Pro Ser Ser Phe Gly Pro Glu Asp Leu Gln Lys 
    130                 135                 140                 


Xaa Gln 
145     


<210> 5622
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<400> 5622
Met Ser Glu Glu Ala Arg Phe Cys Phe Ser Pro Gly Glu Asn Ser Lys 
1               5                   10                  15      


Xaa Met Ser Xaa Glu Leu Phe Ser Ser Xaa Arg Glu Glu Gly Ser Ser 
            20                  25                  30          


Gly Ser Gly Pro Ser Phe Arg Ser Asn Gln Arg Lys Met Leu Asn Leu 
        35                  40                  45              


Leu Leu Glu Arg Asp Xaa Ser Phe Xaa Val Cys Pro Asp Val Pro Arg 
    50                  55                  60                  


Xaa Pro Val Gly Lys Phe Leu Gly Asp Ser Ala Asn Leu Ser Ile Leu 
65                  70                  75                  80  


Ser Gly Gly Xaa Pro Lys Arg Cys Leu Asp Leu Ser Asn Leu Ser Ser 
                85                  90                  95      


Gly Glu Ile Xaa Ala Xaa Gln Leu Xaa Xaa Ser Ala Asp Leu Asp Glu 
            100                 105                 110         


Xaa Gly His Leu Asp Ser Ser Gly Leu Gln Glu Val His Leu Ala Gly 
        115                 120                 125             


Met Asn His Asp Gln His Leu Met Lys Cys Ser Pro Ala Gln Leu Leu 
    130                 135                 140                 


Cys Ser Xaa Pro Asn Gly Leu Asp Arg Gly His Arg Lys Arg Asp Ala 
145                 150                 155                 160 


Met Cys Ser Ser Ser Ala Asn Lys Glu Asn 
                165                 170 


<210> 5623
<211> 249
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<400> 5623
Met Ser Xaa Glu Leu Phe Ser Ser Xaa Arg Glu Glu Gly Ser Ser Gly 
1               5                   10                  15      


Ser Gly Pro Ser Phe Arg Ser Asn Gln Arg Lys Met Leu Asn Leu Leu 
            20                  25                  30          


Leu Glu Arg Asp Xaa Ser Phe Xaa Val Cys Pro Asp Val Pro Arg Xaa 
        35                  40                  45              


Pro Val Gly Lys Phe Leu Gly Asp Ser Ala Asn Leu Ser Ile Leu Ser 
    50                  55                  60                  


Gly Gly Xaa Pro Lys Arg Cys Leu Asp Leu Ser Asn Leu Ser Ser Gly 
65                  70                  75                  80  


Glu Ile Xaa Ala Xaa Gln Leu Xaa Xaa Ser Ala Asp Leu Asp Glu Xaa 
                85                  90                  95      


Gly His Leu Asp Ser Ser Gly Leu Gln Glu Val His Leu Ala Gly Met 
            100                 105                 110         


Asn His Asp Gln His Leu Met Lys Cys Ser Pro Ala Gln Leu Leu Cys 
        115                 120                 125             


Ser Xaa Pro Asn Gly Leu Asp Arg Gly His Arg Lys Arg Asp Ala Met 
    130                 135                 140                 


Cys Ser Ser Ser Ala Asn Lys Glu Asn Asp Asn Gly Asn Leu Val Asp 
145                 150                 155                 160 


Ser Glu Met Lys Tyr Leu Gly Ser Pro Ile Xaa Xaa Val Pro Lys Leu 
                165                 170                 175     


Asp Lys Asn Pro Asn Leu Gly Glu Asp Gln Ala Glu Glu Ile Ser Asp 
            180                 185                 190         


Glu Leu Met Glu Phe Ser Leu Lys Asp Gln Glu Ala Lys Val Ser Arg 
        195                 200                 205             


Ser Gly Leu Tyr Arg Ser Pro Ser Met Pro Glu Asn Leu Asn Arg Pro 
    210                 215                 220                 


Arg Leu Lys Gln Val Glu Lys Phe Lys Asp Asn Xaa Ile Pro Asp Lys 
225                 230                 235                 240 


Val Lys Lys Lys Tyr Phe Ser Gly Gln 
                245                 


<210> 5624
<211> 473
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<400> 5624
Met Ser Xaa Glu Leu Phe Ser Ser Xaa Arg Glu Glu Gly Ser Ser Gly 
1               5                   10                  15      


Ser Gly Pro Ser Phe Arg Ser Asn Gln Arg Lys Met Leu Asn Leu Leu 
            20                  25                  30          


Leu Glu Arg Asp Xaa Ser Phe Xaa Val Cys Pro Asp Val Pro Arg Xaa 
        35                  40                  45              


Pro Val Gly Lys Phe Leu Gly Asp Ser Ala Asn Leu Ser Ile Leu Ser 
    50                  55                  60                  


Gly Gly Xaa Pro Lys Arg Cys Leu Asp Leu Ser Asn Leu Ser Ser Gly 
65                  70                  75                  80  


Glu Ile Xaa Ala Xaa Gln Leu Xaa Xaa Ser Ala Asp Leu Asp Glu Xaa 
                85                  90                  95      


Gly His Leu Asp Ser Ser Gly Leu Gln Glu Val His Leu Ala Gly Met 
            100                 105                 110         


Asn His Asp Gln His Leu Met Lys Cys Ser Pro Ala Gln Leu Leu Cys 
        115                 120                 125             


Ser Xaa Pro Asn Gly Leu Asp Arg Gly His Arg Lys Arg Asp Ala Met 
    130                 135                 140                 


Cys Ser Ser Ser Ala Asn Lys Glu Asn Asp Asn Gly Asn Leu Val Asp 
145                 150                 155                 160 


Ser Glu Met Lys Tyr Leu Gly Ser Pro Ile Xaa Xaa Val Pro Lys Leu 
                165                 170                 175     


Asp Lys Asn Pro Asn Leu Gly Glu Asp Gln Ala Glu Glu Ile Ser Asp 
            180                 185                 190         


Glu Leu Met Glu Phe Ser Leu Lys Asp Gln Glu Ala Lys Val Ser Arg 
        195                 200                 205             


Ser Gly Leu Tyr Arg Ser Pro Ser Met Pro Glu Asn Leu Asn Arg Pro 
    210                 215                 220                 


Arg Leu Lys Gln Val Glu Lys Phe Lys Asp Asn Xaa Ile Pro Asp Lys 
225                 230                 235                 240 


Val Lys Lys Lys Tyr Phe Ser Gly Gln Gly Lys Leu Arg Lys Gly Leu 
                245                 250                 255     


Cys Leu Lys Lys Xaa Val Ser Leu Cys Asp Ile Xaa Ile Xaa Gln Met 
            260                 265                 270         


Leu Glu Glu Asp Ser Asn Gln Gly His Leu Ile Gly Asp Phe Ser Lys 
        275                 280                 285             


Val Cys Ala Leu Pro Xaa Val Ser Gly Lys His Gln Asp Leu Lys Tyr 
    290                 295                 300                 


Val Asn Pro Glu Xaa Val Ala Ala Leu Leu Ser Gly Lys Phe Gln Gly 
305                 310                 315                 320 


Leu Ile Glu Lys Phe Tyr Val Ile Asp Cys Arg Tyr Pro Tyr Glu Tyr 
                325                 330                 335     


Leu Gly Gly His Ile Gln Gly Ala Leu Asn Leu Tyr Ser Gln Glu Glu 
            340                 345                 350         


Leu Phe Asn Phe Phe Leu Lys Lys Pro Ile Val Pro Leu Asp Xaa Gln 
        355                 360                 365             


Lys Arg Ile Ile Ile Val Phe His Cys Glu Phe Ser Ser Glu Arg Gly 
    370                 375                 380                 


Pro Arg Met Cys Arg Cys Leu Arg Glu Glu Asp Arg Ser Leu Asn Gln 
385                 390                 395                 400 


Tyr Pro Ala Leu Tyr Tyr Pro Glu Leu Tyr Ile Leu Lys Gly Gly Tyr 
                405                 410                 415     


Arg Asp Phe Phe Pro Glu Tyr Met Glu Leu Cys Glu Pro Gln Ser Tyr 
            420                 425                 430         


Cys Pro Met His His Gln Asp His Lys Xaa Glu Leu Leu Arg Cys Arg 
        435                 440                 445             


Ser Gln Ser Lys Val Gln Glu Gly Glu Arg Gln Leu Arg Glu Gln Ile 
    450                 455                 460                 


Ala Leu Leu Val Lys Asp Met Ser Pro 
465                 470             


<210> 5625
<211> 443
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<400> 5625
Met Ser Xaa Glu Leu Phe Ser Ser Xaa Arg Glu Glu Gly Ser Ser Gly 
1               5                   10                  15      


Ser Gly Pro Ser Phe Arg Ser Asn Gln Arg Lys Met Leu Asn Leu Leu 
            20                  25                  30          


Leu Glu Arg Asp Xaa Ser Phe Xaa Val Cys Pro Asp Val Pro Arg Xaa 
        35                  40                  45              


Pro Val Gly Lys Phe Leu Gly Asp Ser Ala Asn Leu Ser Ile Leu Ser 
    50                  55                  60                  


Gly Gly Xaa Pro Lys Arg Cys Leu Asp Leu Ser Asn Leu Ser Ser Gly 
65                  70                  75                  80  


Glu Ile Xaa Ala Xaa Gln Leu Xaa Xaa Ser Ala Asp Leu Asp Glu Xaa 
                85                  90                  95      


Gly His Leu Asp Ser Ser Gly Leu Gln Glu Val His Leu Ala Gly Met 
            100                 105                 110         


Asn His Asp Gln His Leu Met Lys Cys Ser Pro Asp Asn Gly Asn Leu 
        115                 120                 125             


Val Asp Ser Glu Met Lys Tyr Leu Gly Ser Pro Ile Xaa Xaa Val Pro 
    130                 135                 140                 


Lys Leu Asp Lys Asn Pro Asn Leu Gly Glu Asp Gln Ala Glu Glu Ile 
145                 150                 155                 160 


Ser Asp Glu Leu Met Glu Phe Ser Leu Lys Asp Gln Glu Ala Lys Val 
                165                 170                 175     


Ser Arg Ser Gly Leu Tyr Arg Ser Pro Ser Met Pro Glu Asn Leu Asn 
            180                 185                 190         


Arg Pro Arg Leu Lys Gln Val Glu Lys Phe Lys Asp Asn Xaa Ile Pro 
        195                 200                 205             


Asp Lys Val Lys Lys Lys Tyr Phe Ser Gly Gln Gly Lys Leu Arg Lys 
    210                 215                 220                 


Gly Leu Cys Leu Lys Lys Xaa Val Ser Leu Cys Asp Ile Xaa Ile Xaa 
225                 230                 235                 240 


Gln Met Leu Glu Glu Asp Ser Asn Gln Gly His Leu Ile Gly Asp Phe 
                245                 250                 255     


Ser Lys Val Cys Ala Leu Pro Xaa Val Ser Gly Lys His Gln Asp Leu 
            260                 265                 270         


Lys Tyr Val Asn Pro Glu Xaa Val Ala Ala Leu Leu Ser Gly Lys Phe 
        275                 280                 285             


Gln Gly Leu Ile Glu Lys Phe Tyr Val Ile Asp Cys Arg Tyr Pro Tyr 
    290                 295                 300                 


Glu Tyr Leu Gly Gly His Ile Gln Gly Ala Leu Asn Leu Tyr Ser Gln 
305                 310                 315                 320 


Glu Glu Leu Phe Asn Phe Phe Leu Lys Lys Pro Ile Val Pro Leu Asp 
                325                 330                 335     


Xaa Gln Lys Arg Ile Ile Ile Val Phe His Cys Glu Phe Ser Ser Glu 
            340                 345                 350         


Arg Gly Pro Arg Met Cys Arg Cys Leu Arg Glu Glu Asp Arg Ser Leu 
        355                 360                 365             


Asn Gln Tyr Pro Ala Leu Tyr Tyr Pro Glu Leu Tyr Ile Leu Lys Gly 
    370                 375                 380                 


Gly Tyr Arg Asp Phe Phe Pro Glu Tyr Met Glu Leu Cys Glu Pro Gln 
385                 390                 395                 400 


Ser Tyr Cys Pro Met His His Gln Asp His Lys Xaa Glu Leu Leu Arg 
                405                 410                 415     


Cys Arg Ser Gln Ser Lys Val Gln Glu Gly Glu Arg Gln Leu Arg Glu 
            420                 425                 430         


Gln Ile Ala Leu Leu Val Lys Asp Met Ser Pro 
        435                 440             


<210> 5626
<211> 400
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<400> 5626
Met Ser Xaa Glu Leu Phe Ser Ser Xaa Arg Glu Glu Gly Ser Ser Gly 
1               5                   10                  15      


Ser Gly Pro Ser Phe Arg Ser Asn Gln Arg Lys Met Leu Asn Leu Leu 
            20                  25                  30          


Leu Glu Arg Asp Xaa Ser Phe Xaa Val Cys Pro Asp Val Pro Arg Xaa 
        35                  40                  45              


Pro Val Gly Lys Phe Leu Gly Asp Ser Ala Asn Leu Ser Ile Leu Ser 
    50                  55                  60                  


Gly Ser Pro Gly Phe Phe Arg Xaa Ser Gly Ser Ala Phe Ser Trp Asp 
65                  70                  75                  80  


Asp Asn Gly Asn Leu Val Asp Ser Glu Met Lys Tyr Leu Gly Ser Pro 
                85                  90                  95      


Ile Xaa Xaa Val Pro Lys Leu Asp Lys Asn Pro Asn Leu Gly Glu Asp 
            100                 105                 110         


Gln Ala Glu Glu Ile Ser Asp Glu Leu Met Glu Phe Ser Leu Lys Asp 
        115                 120                 125             


Gln Glu Ala Lys Val Ser Arg Ser Gly Leu Tyr Arg Ser Pro Ser Met 
    130                 135                 140                 


Pro Glu Asn Leu Asn Arg Pro Arg Leu Lys Gln Val Glu Lys Phe Lys 
145                 150                 155                 160 


Asp Asn Xaa Ile Pro Asp Lys Val Lys Lys Lys Tyr Phe Ser Gly Gln 
                165                 170                 175     


Gly Lys Leu Arg Lys Gly Leu Cys Leu Lys Lys Xaa Val Ser Leu Cys 
            180                 185                 190         


Asp Ile Xaa Ile Xaa Gln Met Leu Glu Glu Asp Ser Asn Gln Gly His 
        195                 200                 205             


Leu Ile Gly Asp Phe Ser Lys Val Cys Ala Leu Pro Xaa Val Ser Gly 
    210                 215                 220                 


Lys His Gln Asp Leu Lys Tyr Val Asn Pro Glu Xaa Val Ala Ala Leu 
225                 230                 235                 240 


Leu Ser Gly Lys Phe Gln Gly Leu Ile Glu Lys Phe Tyr Val Ile Asp 
                245                 250                 255     


Cys Arg Tyr Pro Tyr Glu Tyr Leu Gly Gly His Ile Gln Gly Ala Leu 
            260                 265                 270         


Asn Leu Tyr Ser Gln Glu Glu Leu Phe Asn Phe Phe Leu Lys Lys Pro 
        275                 280                 285             


Ile Val Pro Leu Asp Xaa Gln Lys Arg Ile Ile Ile Val Phe His Cys 
    290                 295                 300                 


Glu Phe Ser Ser Glu Arg Gly Pro Arg Met Cys Arg Cys Leu Arg Glu 
305                 310                 315                 320 


Glu Asp Arg Ser Leu Asn Gln Tyr Pro Ala Leu Tyr Tyr Pro Glu Leu 
                325                 330                 335     


Tyr Ile Leu Lys Gly Gly Tyr Arg Asp Phe Phe Pro Glu Tyr Met Glu 
            340                 345                 350         


Leu Cys Glu Pro Gln Ser Tyr Cys Pro Met His His Gln Asp His Lys 
        355                 360                 365             


Xaa Glu Leu Leu Arg Cys Arg Ser Gln Ser Lys Val Gln Glu Gly Glu 
    370                 375                 380                 


Arg Gln Leu Arg Glu Gln Ile Ala Leu Leu Val Lys Asp Met Ser Pro 
385                 390                 395                 400 


<210> 5627
<211> 258
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<400> 5627
Xaa Ser Arg Ser Gly Leu Tyr Arg Ser Pro Ser Met Pro Glu Asn Leu 
1               5                   10                  15      


Asn Arg Pro Arg Leu Lys Gln Val Glu Lys Phe Lys Asp Asn Xaa Ile 
            20                  25                  30          


Pro Asp Lys Val Lys Lys Lys Tyr Phe Ser Gly Gln Gly Lys Leu Arg 
        35                  40                  45              


Lys Gly Leu Cys Leu Lys Lys Xaa Val Ser Leu Cys Asp Ile Xaa Ile 
    50                  55                  60                  


Xaa Gln Met Leu Glu Glu Asp Ser Asn Gln Gly His Leu Ile Gly Asp 
65                  70                  75                  80  


Phe Ser Lys Val Cys Ala Leu Pro Xaa Val Ser Gly Lys His Gln Asp 
                85                  90                  95      


Leu Lys Tyr Val Asn Pro Glu Xaa Val Ser Arg Phe Leu Glu Met Val 
            100                 105                 110         


Ala Ala Leu Leu Ser Gly Lys Phe Gln Gly Leu Ile Glu Lys Phe Tyr 
        115                 120                 125             


Val Ile Asp Cys Arg Tyr Pro Tyr Glu Tyr Leu Gly Gly His Ile Gln 
    130                 135                 140                 


Gly Ala Leu Asn Leu Tyr Ser Gln Glu Glu Leu Phe Asn Phe Phe Leu 
145                 150                 155                 160 


Lys Lys Pro Ile Val Pro Leu Asp Xaa Gln Lys Arg Ile Ile Ile Val 
                165                 170                 175     


Phe His Cys Glu Phe Ser Ser Glu Arg Gly Pro Arg Met Cys Arg Cys 
            180                 185                 190         


Leu Arg Glu Glu Asp Arg Ser Leu Asn Gln Tyr Pro Ala Leu Tyr Tyr 
        195                 200                 205             


Pro Glu Leu Tyr Ile Leu Lys Gly Gly Tyr Arg Asp Phe Phe Pro Glu 
    210                 215                 220                 


Tyr Met Glu Leu Cys Glu Pro Gln Ser Tyr Cys Pro Met His His Gln 
225                 230                 235                 240 


Asp His Lys Xaa Glu Leu Leu Arg Cys Arg Ser Gln Ser Lys Val Gln 
                245                 250                 255     


Glu Gly 
        


<210> 5628
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<400> 5628
Ala Arg Leu Lys Phe Pro Ile Asp Tyr Pro Tyr Ser Pro Pro Ala Phe 
1               5                   10                  15      


Arg Phe Leu Xaa Lys Met Trp His Pro Asn Ile Tyr Glu Xaa Gly Asp 
            20                  25                  30          


Val Cys Ile Ser Ile Leu His Pro Pro Val Asp Asp Pro Gln Ser Gly 
        35                  40                  45              


Glu Leu Pro Ser Glu Arg Trp Asn Pro Xaa Gln Asn Val Arg Xaa Ile 
    50                  55                  60                  


Leu Leu Ser Val Ile Ser Leu Leu Asn Glu Pro Asn Xaa Phe Ser Pro 
65                  70                  75                  80  


Ala Asn Val Asp Ala Ser Val Met Tyr Arg Lys Trp Lys Glu Ser Lys 
                85                  90                  95      


Gly Lys Asp Arg Glu Tyr Xaa Asp Ile Ile Arg Ser Trp Gly Pro Arg 
            100                 105                 110         


Trp Xaa Arg Ser Val Xaa Ala 
        115                 


<210> 5629
<211> 236
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<400> 5629
Met Ala Arg Pro Leu Val Pro Ser Ser Gln Lys Ala Leu Leu Leu Glu 
1               5                   10                  15      


Leu Lys Gly Leu Gln Glu Glu Pro Val Glu Gly Phe Arg Val Xaa Leu 
            20                  25                  30          


Val Asp Glu Gly Asp Leu Tyr Asn Trp Glu Val Ala Ile Phe Gly Pro 
        35                  40                  45              


Pro Asn Xaa Tyr Tyr Glu Gly Gly Tyr Phe Lys Ala Arg Leu Lys Phe 
    50                  55                  60                  


Pro Ile Asp Tyr Pro Tyr Ser Pro Pro Ala Phe Arg Phe Leu Xaa Lys 
65                  70                  75                  80  


Met Trp His Pro Asn Ile Tyr Glu Xaa Gly Asp Val Cys Ile Ser Ile 
                85                  90                  95      


Leu His Pro Pro Val Asp Asp Pro Gln Ser Gly Glu Leu Pro Ser Glu 
            100                 105                 110         


Arg Trp Asn Pro Xaa Gln Asn Val Arg Xaa Ile Leu Leu Ser Val Ile 
        115                 120                 125             


Ser Leu Leu Asn Glu Pro Asn Xaa Phe Ser Pro Ala Asn Val Asp Ala 
    130                 135                 140                 


Ser Val Met Tyr Arg Lys Trp Lys Glu Ser Lys Gly Lys Asp Arg Glu 
145                 150                 155                 160 


Tyr Xaa Asp Ile Ile Arg Lys Gln Val Leu Gly Xaa Lys Val Asp Ala 
                165                 170                 175     


Glu Arg Asp Gly Val Lys Val Pro Xaa Xaa Leu Ala Glu Tyr Cys Val 
            180                 185                 190         


Lys Xaa Lys Ala Pro Ala Pro Asp Glu Gly Ser Asp Leu Phe Tyr Asp 
        195                 200                 205             


Asp Tyr Tyr Glu Asp Gly Glu Val Glu Glu Glu Ala Asp Ser Cys Phe 
    210                 215                 220                 


Gly Asp Asp Glu Asp Asp Ser Gly Xaa Glu Glu Ser 
225                 230                 235     


<210> 5630
<211> 146
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<400> 5630
Xaa Glu Gly Asp Leu Tyr Asn Trp Glu Val Ala Ile Phe Gly Pro Pro 
1               5                   10                  15      


Asn Xaa Tyr Tyr Glu Gly Gly Tyr Phe Lys Ala Arg Leu Lys Phe Pro 
            20                  25                  30          


Ile Asp Tyr Pro Tyr Ser Pro Pro Ala Phe Arg Phe Leu Xaa Lys Met 
        35                  40                  45              


Trp His Pro Asn Ile Tyr Glu Xaa Gly Asp Val Cys Ile Ser Ile Leu 
    50                  55                  60                  


His Pro Pro Val Asp Asp Pro Gln Ser Gly Glu Leu Pro Ser Glu Arg 
65                  70                  75                  80  


Trp Asn Pro Xaa Gln Asn Val Arg Xaa Ile Leu Leu Ser Val Ile Ser 
                85                  90                  95      


Leu Leu Asn Glu Pro Asn Xaa Phe Ser Pro Ala Asn Val Asp Ala Ser 
            100                 105                 110         


Val Met Tyr Arg Lys Trp Lys Glu Ser Lys Gly Lys Asp Arg Glu Tyr 
        115                 120                 125             


Xaa Asp Ile Ile Arg Arg Ser Trp Gly Pro Arg Trp Xaa Arg Ser Val 
    130                 135                 140                 


Xaa Ala 
145     


<210> 5631
<211> 107
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<400> 5631
Tyr Phe Lys Ala Arg Leu Lys Phe Pro Ile Asp Tyr Pro Tyr Ser Pro 
1               5                   10                  15      


Pro Ala Phe Arg Phe Leu Xaa Lys Met Trp His Pro Asn Ile Tyr Glu 
            20                  25                  30          


Xaa Gly Asp Val Cys Ile Ser Ile Leu His Pro Pro Val Asp Ala Glu 
        35                  40                  45              


Arg Asp Gly Val Lys Val Pro Xaa Xaa Leu Ala Glu Tyr Cys Val Lys 
    50                  55                  60                  


Xaa Lys Ala Pro Ala Pro Asp Glu Gly Ser Asp Leu Phe Tyr Asp Asp 
65                  70                  75                  80  


Tyr Tyr Glu Asp Gly Glu Val Glu Glu Glu Ala Asp Ser Cys Phe Gly 
                85                  90                  95      


Asp Asp Glu Asp Asp Ser Gly Xaa Glu Glu Ser 
            100                 105         


<210> 5632
<211> 353
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<400> 5632
Met Val Asp Tyr Ser Val Trp Asp His Ile Glu Val Ser Asp Asp Glu 
1               5                   10                  15      


Asp Glu Xaa His Pro Asn Ile Asp Xaa Ala Ser Leu Phe Arg Trp Arg 
            20                  25                  30          


His Gln Ala Arg Val Glu Arg Met Glu Gln Phe Gln Lys Glu Lys Glu 
        35                  40                  45              


Glu Leu Asp Arg Gly Cys Arg Glu Cys Lys Arg Lys Val Ala Glu Cys 
    50                  55                  60                  


Gln Arg Lys Leu Lys Glu Leu Glu Val Ala Glu Gly Gly Lys Ala Glu 
65                  70                  75                  80  


Leu Glu Arg Leu Gln Ala Glu Ala Gln Gln Leu Arg Lys Glu Glu Arg 
                85                  90                  95      


Ser Trp Glu Gln Lys Leu Glu Glu Met Arg Lys Lys Glu Lys Ser Met 
            100                 105                 110         


Pro Trp Asn Val Asp Xaa Leu Ser Lys Asp Gly Phe Ser Lys Ala His 
        115                 120                 125             


Ala His Ala Pro Ala Xaa Leu Met Leu Met Ala Ser Ser Pro Pro Pro 
    130                 135                 140                 


Pro Trp Met Gly Trp Ala Leu Arg Pro Arg Pro Ala Arg Pro Arg Ser 
145                 150                 155                 160 


Arg Arg Ser Ala Ala Leu Pro Gln Pro Xaa Pro Pro Leu Xaa Leu Pro 
                165                 170                 175     


Gln Ser Met Val Asn Xaa Lys Pro Glu Lys Xaa Glu Glu Asp Ser Glu 
            180                 185                 190         


Glu Val Arg Glu Gln Lys His Lys Xaa Phe Val Glu Lys Tyr Glu Lys 
        195                 200                 205             


Gln Ile Lys His Phe Gly Met Leu Arg Arg Trp Asp Asp Ser Gln Lys 
    210                 215                 220                 


Tyr Leu Ser Asp Asn Val His Leu Val Cys Glu Glu Xaa Ala Asn Tyr 
225                 230                 235                 240 


Leu Val Ile Trp Cys Ile Asp Leu Glu Val Glu Glu Lys Cys Ala Leu 
                245                 250                 255     


Met Glu Gln Val Ala His Gln Xaa Ile Val Met Gln Phe Ile Leu Glu 
            260                 265                 270         


Leu Ala Lys Ser Leu Lys Val Asp Pro Arg Ala Cys Phe Arg Gln Phe 
        275                 280                 285             


Phe Xaa Lys Ile Lys Xaa Ala Asp Arg Gln Tyr Met Glu Gly Phe Asn 
    290                 295                 300                 


Asp Glu Leu Glu Ala Phe Lys Glu Arg Val Arg Gly Arg Ala Lys Leu 
305                 310                 315                 320 


Arg Ile Glu Lys Ala Met Lys Glu Tyr Glu Glu Glu Glu Arg Lys Lys 
                325                 330                 335     


Arg Leu Gly Pro Gly Gly Leu Asp Pro Val Glu Val Tyr Glu Ser Leu 
            340                 345                 350         


Pro 
    


<210> 5633
<211> 230
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<400> 5633
Met Val Asp Tyr Ser Val Trp Asp His Ile Glu Val Ser Asp Asp Glu 
1               5                   10                  15      


Asp Glu Xaa His Pro Asn Ile Asp Xaa Ala Ser Leu Phe Arg Trp Arg 
            20                  25                  30          


His Gln Ala Arg Val Glu Arg Met Glu Gln Phe Gln Lys Glu Lys Glu 
        35                  40                  45              


Glu Leu Asp Arg Gly Cys Arg Glu Cys Lys Arg Lys Val Ala Glu Cys 
    50                  55                  60                  


Gln Arg Lys Leu Lys Glu Leu Glu Val Ala Glu Gly Gly Lys Ala Glu 
65                  70                  75                  80  


Leu Glu Arg Leu Gln Ala Glu Ala Gln Gln Leu Arg Lys Glu Glu Arg 
                85                  90                  95      


Ser Trp Glu Gln Lys Leu Glu Glu Met Arg Lys Lys Glu Lys Ser Met 
            100                 105                 110         


Pro Trp Asn Val Asp Xaa Leu Ser Lys Asp Gly Phe Ser Lys Ser Met 
        115                 120                 125             


Val Asn Xaa Lys Pro Glu Lys Xaa Glu Glu Asp Ser Glu Glu Phe Phe 
    130                 135                 140                 


Xaa Lys Ile Lys Xaa Ala Asp Arg Gln Tyr Met Glu Gly Phe Asn Asp 
145                 150                 155                 160 


Glu Leu Glu Ala Phe Lys Glu Arg Val Arg Gly Arg Ala Lys Leu Arg 
                165                 170                 175     


Ile Glu Lys Ala Met Lys Glu Tyr Glu Glu Glu Glu Arg Lys Lys Arg 
            180                 185                 190         


Leu Gly Pro Gly Gly Leu Asp Pro Val Glu Val Tyr Glu Ser Leu Pro 
        195                 200                 205             


Glu Glu Leu Gln Lys Cys Phe Asp Val Lys Asp Val Gln Met Leu Gln 
    210                 215                 220                 


Asp Ala Ile Ser Lys Met 
225                 230 


<210> 5634
<211> 378
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<400> 5634
Met Val Asp Tyr Ser Val Trp Asp His Ile Glu Val Ser Asp Asp Glu 
1               5                   10                  15      


Asp Glu Xaa His Pro Asn Ile Asp Xaa Ala Ser Leu Phe Arg Trp Arg 
            20                  25                  30          


His Gln Ala Arg Val Glu Arg Met Glu Gln Phe Gln Lys Glu Lys Glu 
        35                  40                  45              


Glu Leu Asp Arg Gly Cys Arg Glu Cys Lys Arg Lys Val Ala Glu Cys 
    50                  55                  60                  


Gln Arg Lys Leu Lys Glu Leu Glu Val Ala Glu Gly Gly Lys Ala Glu 
65                  70                  75                  80  


Leu Glu Arg Leu Gln Ala Glu Ala Gln Gln Leu Arg Lys Glu Glu Arg 
                85                  90                  95      


Ser Trp Glu Gln Lys Leu Glu Glu Met Arg Lys Lys Glu Lys Ser Met 
            100                 105                 110         


Pro Trp Asn Val Asp Xaa Leu Ser Lys Asp Gly Phe Ser Lys Ser Met 
        115                 120                 125             


Val Asn Xaa Lys Pro Glu Lys Xaa Glu Glu Asp Ser Glu Glu Val Arg 
    130                 135                 140                 


Glu Gln Lys His Lys Xaa Phe Val Glu Lys Tyr Glu Lys Gln Ile Lys 
145                 150                 155                 160 


His Phe Gly Met Leu Arg Arg Trp Asp Asp Ser Gln Lys Tyr Leu Ser 
                165                 170                 175     


Asp Asn Val His Leu Val Cys Glu Glu Xaa Ala Asn Tyr Leu Val Ile 
            180                 185                 190         


Trp Cys Ile Asp Leu Glu Val Glu Glu Lys Cys Ala Leu Met Glu Gln 
        195                 200                 205             


Val Ala His Gln Xaa Ile Val Met Gln Phe Ile Leu Glu Leu Ala Lys 
    210                 215                 220                 


Ser Leu Lys Val Asp Pro Arg Ala Cys Phe Arg Gln Phe Phe Xaa Lys 
225                 230                 235                 240 


Ile Lys Xaa Ala Asp Arg Gln Tyr Met Glu Gly Phe Asn Asp Glu Leu 
                245                 250                 255     


Glu Ala Phe Lys Glu Arg Val Arg Gly Arg Ala Lys Leu Arg Ile Glu 
            260                 265                 270         


Lys Ala Met Lys Glu Tyr Glu Glu Glu Glu Arg Lys Lys Arg Leu Gly 
        275                 280                 285             


Pro Gly Gly Leu Asp Pro Val Glu Val Tyr Glu Ser Leu Pro Glu Glu 
    290                 295                 300                 


Leu Gln Lys Cys Phe Asp Val Lys Asp Val Gln Met Leu Gln Asp Ala 
305                 310                 315                 320 


Ile Ser Lys Met Asp Pro Xaa Asp Ala Lys Tyr His Met Gln Arg Cys 
                325                 330                 335     


Ile Asp Ser Gly Leu Trp Val Pro Asn Ser Lys Ala Ser Glu Ala Lys 
            340                 345                 350         


Glu Gly Glu Glu Ala Gly Pro Gly Asp Pro Leu Leu Glu Ala Val Pro 
        355                 360                 365             


Lys Xaa Gly Asp Glu Lys Asp Val Ser Val 
    370                 375             


<210> 5635
<211> 60
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<400> 5635
Met Val Asp Tyr Ser Val Trp Asp His Ile Glu Val Ser Asp Asp Glu 
1               5                   10                  15      


Asp Glu Xaa His Pro Asn Ile Asp Xaa Ala Ser Leu Phe Arg Trp Arg 
            20                  25                  30          


His Gln Xaa Gly Pro Cys Phe Val Xaa Leu Arg Trp Gln Trp Arg His 
        35                  40                  45              


Leu Ser Ser Leu Gln Leu Pro Pro Ser Gly Leu Lys 
    50                  55                  60  


<210> 5636
<211> 104
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<400> 5636
Xaa Asn Asp Glu Leu Glu Ala Phe Lys Glu Arg Val Arg Gly Arg Ala 
1               5                   10                  15      


Lys Leu Arg Ile Glu Lys Ala Met Lys Glu Tyr Glu Glu Glu Glu Arg 
            20                  25                  30          


Lys Lys Arg Leu Gly Pro Gly Gly Leu Asp Pro Val Glu Val Tyr Glu 
        35                  40                  45              


Ser Leu Pro Glu Glu Leu Gln Lys Cys Phe Asp Val Lys Asp Val Gln 
    50                  55                  60                  


Met Leu Gln Asp Ala Ile Ser Lys Met Asp Pro Xaa Val Ser Asn Pro 
65                  70                  75                  80  


Arg Ala Pro Cys Leu Pro Gly Gly Pro Cys Val Ser Pro Ser Pro Val 
                85                  90                  95      


Ser Gln Val Ser Glu Ala Gly Trp 
            100                 


<210> 5637
<211> 184
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<400> 5637
Xaa Tyr Leu Val Ile Trp Cys Ile Asp Leu Glu Val Glu Glu Lys Cys 
1               5                   10                  15      


Ala Leu Met Glu Gln Val Ala His Gln Xaa Ile Val Met Gln Phe Ile 
            20                  25                  30          


Leu Glu Leu Ala Lys Ser Leu Lys Val Asp Pro Arg Ala Cys Phe Arg 
        35                  40                  45              


Gln Phe Phe Xaa Lys Ile Lys Xaa Ala Asp Arg Gln Tyr Met Glu Gly 
    50                  55                  60                  


Phe Asn Asp Glu Leu Glu Ala Phe Lys Glu Arg Val Arg Gly Arg Ala 
65                  70                  75                  80  


Lys Leu Arg Ile Glu Lys Ala Met Lys Glu Tyr Glu Glu Glu Glu Arg 
                85                  90                  95      


Lys Lys Arg Leu Gly Pro Gly Gly Leu Asp Pro Val Glu Glu Leu Gln 
            100                 105                 110         


Lys Cys Phe Asp Val Lys Asp Val Gln Met Leu Gln Asp Ala Ile Ser 
        115                 120                 125             


Lys Met Asp Pro Xaa Asp Ala Lys Tyr His Met Gln Arg Cys Ile Asp 
    130                 135                 140                 


Ser Gly Leu Trp Val Pro Asn Ser Lys Ala Ser Glu Ala Lys Glu Gly 
145                 150                 155                 160 


Glu Glu Ala Gly Pro Gly Asp Pro Leu Leu Glu Ala Val Pro Lys Xaa 
                165                 170                 175     


Gly Asp Glu Lys Asp Val Ser Val 
            180                 


<210> 5638
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<400> 5638
Met Gln Xaa Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Xaa Cys Leu Leu Ile Ser Tyr Xaa Xaa Asn Lys Phe Pro Ser Glu Tyr 
            20                  25                  30          


Val Pro Xaa Val Phe Asp Asn Tyr Ala Val Xaa Val Met Ile Gly Gly 
        35                  40                  45              


Glu Pro Tyr Xaa Leu Gly Leu Phe Asp Xaa Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Xaa Asp Val Phe Leu Val 
65                  70                  75                  80  


Cys Phe Ser Val Val Ser Pro Ser Ser Phe Glu Asn Val Lys Glu Lys 
                85                  90                  95      


Trp Val Pro Glu Ile Xaa His His Cys Pro Lys Xaa Pro Phe Leu Leu 
            100                 105                 110         


Val Gly Xaa Gln Ile Asp Leu Arg Asp Asp Pro Ser Xaa Ile Glu Lys 
        115                 120                 125             


Leu Ala Lys Asn Lys Gln Lys Pro 
    130                 135     


<210> 5639
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<400> 5639
Met Gln Xaa Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Xaa Cys Leu Leu Ile Ser Tyr Xaa Xaa Asn Lys Phe Pro Ser Glu Tyr 
            20                  25                  30          


Val Pro Xaa Val Phe Asp Asn Tyr Ala Val Xaa Val Met Ile Gly Gly 
        35                  40                  45              


Glu Pro Tyr Xaa Leu Gly Leu Phe Asp Xaa Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Xaa Asp Val Phe Leu Val 
65                  70                  75                  80  


Cys Phe Ser Val Val Ser Pro Ser Ser Phe Glu Asn Val Lys Glu Lys 
                85                  90                  95      


Trp Val Pro Glu Ile Xaa His His Cys Pro Lys Xaa Pro Phe Leu Leu 
            100                 105                 110         


Val Gly Xaa Gln Ile Asp Leu Arg Asp Asp Pro Ser Xaa Ile Glu Lys 
        115                 120                 125             


Leu Ala Lys Asn Lys Gln Lys Pro Ile Xaa Pro Glu Xaa Ala Glu Lys 
    130                 135                 140                 


Leu Ala Arg Asp Leu Lys Ala Val Lys Tyr Val Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Xaa Gln Lys Gly Leu Lys Asn Val Phe Asp Glu Ala Ile Leu Ala Ala 
                165                 170                 175     


Leu Glu Pro Pro Glu Pro Lys Lys Ser Arg Arg Cys Val Leu Leu 
            180                 185                 190     


<210> 5640
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<400> 5640
Met Gln Xaa Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Xaa Cys Leu Leu Ile Ser Tyr Xaa Xaa Asn Lys Phe Pro Ser Glu Tyr 
            20                  25                  30          


Val Pro Xaa Val Phe Asp Asn Tyr Ala Val Xaa Val Met Ile Gly Gly 
        35                  40                  45              


Glu Pro Tyr Xaa Leu Gly Leu Phe Asp Xaa Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Xaa Asp Val Phe Leu Val 
65                  70                  75                  80  


Cys Phe Ser Val Val Ser Pro Ser Ser Phe Glu Asn Val Lys Glu Lys 
                85                  90                  95      


Trp Val Pro Glu Ile Xaa His His Cys Pro Lys Xaa Pro Phe Leu Leu 
            100                 105                 110         


Val Gly Xaa Gln Ile Asp Leu Arg Asp Asp Pro Ser Xaa Ile Glu Lys 
        115                 120                 125             


Leu Ala Lys Asn Lys Gln Lys Pro Ile Xaa Pro Glu Xaa Ala Glu Lys 
    130                 135                 140                 


Leu Ala Arg Asp Leu Lys Ala Val Lys Tyr Val Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Xaa Gln Arg Gly Leu Lys Asn Val Phe Asp Glu Ala Ile Leu Ala Ala 
                165                 170                 175     


Leu Glu Pro Pro Glu Xaa Gln Pro Lys Arg Lys Cys Cys Ile Phe 
            180                 185                 190     


<210> 5641
<211> 1018
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<400> 5641
Met Ile Leu Lys Asp Lys Leu Glu Lys Xaa Arg Arg Glu Ser Gln Ser 
1               5                   10                  15      


Glu Arg Glu Glu Phe Glu Ser Glu Phe Lys Gln Gln Tyr Glu Arg Glu 
            20                  25                  30          


Lys Val Leu Leu Xaa Glu Glu Asn Lys Lys Leu Xaa Ser Glu Leu Asp 
        35                  40                  45              


Lys Leu Xaa Xaa Leu Tyr Glu Asn Leu Ser Ile His Asn Gln Gln Leu 
    50                  55                  60                  


Glu Glu Glu Val Lys Asp Leu Ala Asp Lys Lys Glu Ser Val Ala His 
65                  70                  75                  80  


Trp Glu Ala Gln Ile Xaa Glu Ile Ile Gln Trp Val Ser Asp Glu Lys 
                85                  90                  95      


Asp Ala Arg Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Xaa Glu Glu 
            100                 105                 110         


Leu Glu Ala Leu Arg Asn Ser Ser Leu Gly Xaa Arg Ala Xaa Asp Met 
        115                 120                 125             


Pro Trp Lys Met Arg Arg Phe Ala Lys Leu Asp Met Ser Ala Arg Leu 
    130                 135                 140                 


Glu Leu Gln Ser Ala Leu Asp Ala Glu Ile Arg Ala Lys Gln Ala Ile 
145                 150                 155                 160 


Gln Glu Glu Leu Asn Lys Val Lys Ala Ser Asn Ile Ile Xaa Glu Cys 
                165                 170                 175     


Lys Leu Lys Asp Ser Glu Lys Lys Asn Leu Glu Leu Leu Ser Glu Ile 
            180                 185                 190         


Glu Gln Leu Ile Lys Asp Xaa Glu Glu Leu Arg Ser Glu Lys Gly Ile 
        195                 200                 205             


Glu His Gln Asp Ser Gln His Ser Phe Leu Ala Phe Leu Asn Xaa Pro 
    210                 215                 220                 


Xaa Asp Ala Leu Asp Gln Phe Glu Xaa Asp Pro Val Glu Asn Xaa Tyr 
225                 230                 235                 240 


Val Trp Asn Pro Ser Val Lys Phe His Ile Gln Ser Arg Ser Xaa Ser 
                245                 250                 255     


Pro Ser Xaa Ser Ser Glu Ala Glu Pro Val Lys Xaa Val Asp Ser Xaa 
            260                 265                 270         


Pro Leu Ser Val His Xaa Pro Xaa Leu Arg Lys Lys Gly Cys Pro Gly 
        275                 280                 285             


Ser Xaa Gly Phe Pro Pro Lys Arg Lys Xaa His Gln Phe Phe Val Lys 
    290                 295                 300                 


Ser Phe Xaa Xaa Pro Xaa Lys Cys His Gln Cys Xaa Ser Leu Met Val 
305                 310                 315                 320 


Gly Leu Ile Arg Gln Gly Cys Ser Cys Glu Val Cys Gly Phe Ser Cys 
                325                 330                 335     


His Ile Xaa Cys Val Asn Lys Ala Pro Xaa Xaa Cys Pro Val Pro Pro 
            340                 345                 350         


Glu Gln Xaa Lys Gly Pro Leu Gly Ile Asp Pro Gln Lys Gly Ile Gly 
        355                 360                 365             


Xaa Ala Tyr Glu Gly His Val Arg Ile Pro Lys Pro Ala Gly Val Lys 
    370                 375                 380                 


Lys Gly Trp Gln Arg Ala Leu Ala Ile Val Cys Asp Phe Lys Leu Phe 
385                 390                 395                 400 


Leu Tyr Asp Ile Ala Glu Gly Lys Ala Ser Gln Pro Ser Val Val Ile 
                405                 410                 415     


Ser Gln Val Ile Asp Met Arg Asp Glu Glu Phe Ser Val Ser Ser Val 
            420                 425                 430         


Leu Ala Ser Asp Val Ile His Ala Ser Arg Lys Asp Ile Pro Cys Ile 
        435                 440                 445             


Phe Arg Val Xaa Ala Ser Gln Leu Ser Ala Ser Asn Asn Lys Cys Ser 
    450                 455                 460                 


Ile Leu Met Leu Ala Asp Xaa Glu Asn Glu Lys Asn Lys Trp Val Gly 
465                 470                 475                 480 


Val Leu Ser Glu Leu His Lys Ile Leu Lys Lys Asn Lys Phe Arg Asp 
                485                 490                 495     


Arg Ser Val Tyr Val Pro Lys Glu Ala Tyr Asp Ser Xaa Leu Pro Leu 
            500                 505                 510         


Ile Lys Xaa Xaa Gln Ala Ala Ala Ile Ile Asp His Glu Arg Ile Ala 
        515                 520                 525             


Leu Gly Asn Glu Glu Gly Leu Phe Val Val His Val Xaa Lys Asp Glu 
    530                 535                 540                 


Ile Ile Arg Val Gly Asp Asn Lys Lys Ile His Gln Ile Glu Leu Ile 
545                 550                 555                 560 


Pro Asn Asp Gln Leu Val Ala Val Ile Ser Gly Arg Asn Arg His Val 
                565                 570                 575     


Arg Leu Phe Pro Met Ser Ala Leu Asp Gly Arg Glu Xaa Asp Phe Tyr 
            580                 585                 590         


Lys Leu Ser Glu Xaa Lys Gly Cys Gln Xaa Val Xaa Ser Gly Lys Val 
        595                 600                 605             


Arg His Gly Ala Leu Xaa Cys Leu Cys Val Ala Met Lys Arg Gln Val 
    610                 615                 620                 


Leu Cys Tyr Glu Leu Phe Gln Ser Lys Xaa Arg His Arg Lys Phe Lys 
625                 630                 635                 640 


Glu Ile Gln Val Pro Tyr Asn Val Gln Trp Met Ala Ile Phe Ser Glu 
                645                 650                 655     


Gln Leu Cys Val Gly Phe Gln Ser Gly Phe Leu Arg Tyr Pro Leu Asn 
            660                 665                 670         


Gly Glu Gly Asn Pro Tyr Ser Met Leu His Ser Asn Asp His Xaa Leu 
        675                 680                 685             


Ser Phe Ile Ala His Gln Pro Met Asp Ala Ile Cys Ala Val Glu Ile 
    690                 695                 700                 


Ser Ser Lys Glu Tyr Leu Leu Cys Phe Asn Ser Ile Gly Ile Tyr Xaa 
705                 710                 715                 720 


Asp Cys Gln Gly Arg Arg Ser Arg Gln Gln Glu Leu Met Trp Pro Ala 
                725                 730                 735     


Asn Pro Ser Ser Cys Cys Tyr Asn Ala Pro Tyr Leu Ser Val Tyr Ser 
            740                 745                 750         


Glu Asn Ala Val Asp Ile Phe Asp Val Asn Ser Met Glu Trp Ile Gln 
        755                 760                 765             


Xaa Leu Pro Leu Lys Lys Val Arg Pro Leu Asn Asn Glu Gly Ser Leu 
    770                 775                 780                 


Asn Leu Leu Gly Leu Glu Xaa Ile Arg Leu Ile Tyr Phe Lys Asn Lys 
785                 790                 795                 800 


Met Ala Glu Gly Asp Glu Leu Val Val Pro Glu Xaa Ser Asp Asn Ser 
                805                 810                 815     


Arg Lys Gln Met Val Arg Asn Ile Asn Asn Lys Arg Arg Tyr Ser Phe 
            820                 825                 830         


Arg Val Pro Glu Glu Glu Arg Met Gln Gln Arg Arg Glu Met Leu Arg 
        835                 840                 845             


Asp Pro Glu Met Arg Asn Lys Leu Ile Ser Asn Pro Xaa Asn Phe Asn 
    850                 855                 860                 


His Ile Ala His Met Gly Pro Gly Asp Gly Ile Gln Ile Leu Lys Asp 
865                 870                 875                 880 


Leu Pro Met Asn Pro Arg Pro Gln Glu Ser Arg Xaa Val Phe Ser Gly 
                885                 890                 895     


Ser Val Ser Ile Pro Ser Ile Xaa Lys Ser Arg Pro Glu Pro Gly Arg 
            900                 905                 910         


Ser Met Ser Ala Ser Ser Gly Leu Ser Ala Arg Ser Ser Ala Gln Asn 
        915                 920                 925             


Gly Ser Ala Leu Lys Arg Glu Phe Ser Gly Gly Ser Tyr Ser Ala Lys 
    930                 935                 940                 


Arg Gln Pro Met Pro Ser Pro Ser Glu Gly Ser Leu Ser Ser Gly Gly 
945                 950                 955                 960 


Met Asp Gln Gly Ser Asp Ala Pro Ala Arg Asp Phe Asp Gly Glu Asp 
                965                 970                 975     


Ser Asp Ser Pro Arg His Ser Xaa Ala Ser Asn Ser Ser Asn Leu Ser 
            980                 985                 990         


Ser Pro Pro Ser Pro Ala Ser Pro  Arg Lys Xaa Lys Ser  Leu Ser Leu 
        995                 1000                 1005             


Glu Ser  Xaa Asp Arg Gly Ser  Trp Asp Pro 
    1010                 1015             


<210> 5642
<211> 1638
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1091)..(1091)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1161)..(1161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1222)..(1222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1224)..(1224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1234)..(1234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1340)..(1340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1411)..(1411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1432)..(1432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1481)..(1481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1512)..(1512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1524)..(1524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1604)..(1604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1623)..(1623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1631)..(1631)
<223> Selenocysteine

<400> 5642
Met Ser Gly Glu Val Arg Leu Arg Gln Leu Glu Gln Phe Ile Leu Asp 
1               5                   10                  15      


Gly Pro Ala Gln Xaa Asn Gly Gln Cys Phe Ser Val Glu Xaa Leu Leu 
            20                  25                  30          


Asp Ile Leu Ile Cys Leu Tyr Asp Glu Cys Asn Asn Ser Pro Leu Arg 
        35                  40                  45              


Arg Glu Lys Asn Ile Leu Glu Tyr Leu Glu Trp Ala Lys Pro Phe Xaa 
    50                  55                  60                  


Ser Lys Val Lys Gln Met Arg Leu His Arg Glu Asp Phe Glu Ile Leu 
65                  70                  75                  80  


Lys Val Ile Gly Arg Gly Ala Phe Gly Glu Val Ala Val Val Lys Leu 
                85                  90                  95      


Lys Asn Ala Asp Lys Val Phe Ala Met Lys Ile Leu Asn Lys Trp Glu 
            100                 105                 110         


Met Leu Lys Arg Ala Glu Xaa Ala Cys Phe Arg Glu Glu Arg Asp Val 
        115                 120                 125             


Leu Val Asn Gly Asp Asn Lys Trp Ile Xaa Xaa Leu His Tyr Ala Phe 
    130                 135                 140                 


Gln Asp Asp Asn Asn Leu Tyr Leu Val Met Asp Tyr Tyr Val Gly Gly 
145                 150                 155                 160 


Asp Leu Leu Xaa Leu Leu Ser Lys Phe Glu Asp Arg Leu Pro Glu Asp 
                165                 170                 175     


Met Ala Arg Phe Tyr Leu Ala Glu Met Val Ile Ala Ile Asp Ser Val 
            180                 185                 190         


His Gln Leu His Tyr Val His Arg Asp Ile Lys Pro Asp Asn Ile Leu 
        195                 200                 205             


Met Asp Met Asn Gly His Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu 
    210                 215                 220                 


Lys Leu Met Glu Asp Gly Xaa Val Gln Ser Ser Val Ala Val Gly Xaa 
225                 230                 235                 240 


Pro Asp Tyr Ile Ser Pro Glu Ile Leu Gln Ala Met Glu Asp Gly Lys 
                245                 250                 255     


Gly Arg Tyr Gly Pro Glu Cys Asp Trp Trp Ser Leu Gly Val Cys Met 
            260                 265                 270         


Tyr Glu Met Leu Tyr Gly Glu Xaa Pro Phe Tyr Ala Glu Ser Leu Val 
        275                 280                 285             


Glu Xaa Tyr Gly Lys Ile Met Asn His Lys Glu Arg Phe Gln Phe Pro 
    290                 295                 300                 


Ala Gln Val Xaa Asp Val Ser Glu Asn Ala Lys Asp Leu Ile Arg Arg 
305                 310                 315                 320 


Leu Ile Cys Ser Arg Glu His Arg Leu Gly Gln Asn Gly Ile Glu Asp 
                325                 330                 335     


Phe Lys Lys His Pro Phe Phe Ser Gly Ile Asp Trp Asp Asn Ile Arg 
            340                 345                 350         


Asn Cys Glu Ala Pro Tyr Ile Pro Glu Val Ser Ser Pro Xaa Asp Xaa 
        355                 360                 365             


Ser Asn Phe Asp Val Asp Asp Asp Cys Leu Lys Asn Ser Glu Xaa Met 
    370                 375                 380                 


Pro Pro Pro Xaa His Xaa Ala Phe Ser Gly His His Leu Pro Phe Val 
385                 390                 395                 400 


Gly Phe Xaa Tyr Xaa Ser Ser Cys Val Leu Ser Asp Arg Ser Cys Leu 
                405                 410                 415     


Arg Val Xaa Ala Gly Pro Xaa Ser Leu Asp Leu Asp Val Asn Val Gln 
            420                 425                 430         


Arg Xaa Leu Asp Asn Asn Leu Ala Xaa Glu Ala Tyr Glu Arg Arg Ile 
        435                 440                 445             


Lys Arg Leu Glu Gln Glu Lys Leu Glu Leu Ser Arg Lys Leu Gln Glu 
    450                 455                 460                 


Ser Xaa Gln Xaa Val Gln Ala Leu Gln Tyr Ser Xaa Val Asp Gly Pro 
465                 470                 475                 480 


Leu Xaa Ala Ser Lys Asp Leu Glu Ile Lys Asn Leu Lys Glu Glu Ile 
                485                 490                 495     


Glu Lys Leu Arg Lys Gln Val Xaa Glu Ser Ser His Leu Glu Gln Gln 
            500                 505                 510         


Leu Glu Glu Ala Asn Ala Val Arg Gln Glu Leu Asp Asp Ala Phe Arg 
        515                 520                 525             


Gln Ile Lys Ala Tyr Glu Lys Gln Ile Lys Xaa Leu Gln Gln Glu Arg 
    530                 535                 540                 


Glu Asp Leu Asn Lys Leu Glu Val His Xaa Glu Ala Leu Ala Ala Glu 
545                 550                 555                 560 


Ala Ser Lys Asp Arg Lys Leu Arg Glu Gln Ser Glu His Tyr Ser Lys 
                565                 570                 575     


Gln Leu Glu Asn Glu Leu Glu Gly Leu Lys Gln Lys Gln Ile Ser Tyr 
            580                 585                 590         


Ser Pro Gly Val Cys Ser Ile Glu His Gln Gln Glu Ile Xaa Lys Leu 
        595                 600                 605             


Lys Xaa Asp Leu Glu Lys Lys Ser Ile Phe Tyr Glu Glu Glu Leu Ser 
    610                 615                 620                 


Lys Arg Glu Gly Ile His Ala Asn Glu Ile Lys Asn Leu Lys Lys Glu 
625                 630                 635                 640 


Leu His Asp Ser Glu Gly Gln Gln Leu Ala Leu Asn Lys Glu Ile Met 
                645                 650                 655     


Ile Leu Lys Asp Lys Leu Glu Lys Xaa Arg Arg Glu Ser Gln Ser Glu 
            660                 665                 670         


Arg Glu Glu Phe Glu Ser Glu Phe Lys Gln Gln Tyr Glu Arg Glu Lys 
        675                 680                 685             


Val Leu Leu Xaa Glu Glu Asn Lys Lys Leu Xaa Ser Glu Leu Asp Lys 
    690                 695                 700                 


Leu Xaa Xaa Leu Tyr Glu Asn Leu Ser Ile His Asn Gln Gln Leu Glu 
705                 710                 715                 720 


Glu Glu Val Lys Asp Leu Ala Asp Lys Lys Glu Ser Val Ala His Trp 
                725                 730                 735     


Glu Ala Gln Ile Xaa Glu Ile Ile Gln Trp Val Ser Asp Glu Lys Asp 
            740                 745                 750         


Ala Arg Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Xaa Glu Glu Leu 
        755                 760                 765             


Glu Ala Leu Arg Asn Ser Ser Leu Gly Xaa Arg Ala Xaa Asp Met Pro 
    770                 775                 780                 


Trp Lys Met Arg Arg Phe Ala Lys Leu Asp Met Ser Ala Arg Leu Glu 
785                 790                 795                 800 


Leu Gln Ser Ala Leu Asp Ala Glu Ile Arg Ala Lys Gln Ala Ile Gln 
                805                 810                 815     


Glu Glu Leu Asn Lys Val Lys Ala Ser Asn Ile Ile Xaa Glu Cys Lys 
            820                 825                 830         


Leu Lys Asp Ser Glu Lys Lys Asn Leu Glu Leu Leu Ser Glu Ile Glu 
        835                 840                 845             


Gln Leu Ile Lys Asp Xaa Glu Glu Leu Arg Ser Glu Lys Gly Ile Glu 
    850                 855                 860                 


His Gln Asp Ser Gln His Ser Phe Leu Ala Phe Leu Asn Xaa Pro Xaa 
865                 870                 875                 880 


Asp Ala Leu Asp Gln Phe Glu Xaa Val Asp Ser Xaa Pro Leu Ser Val 
                885                 890                 895     


His Xaa Pro Xaa Leu Arg Lys Lys Gly Cys Pro Gly Ser Xaa Gly Phe 
            900                 905                 910         


Pro Pro Lys Arg Lys Xaa His Gln Phe Phe Val Lys Ser Phe Xaa Xaa 
        915                 920                 925             


Pro Xaa Lys Cys His Gln Cys Xaa Ser Leu Met Val Gly Leu Ile Arg 
    930                 935                 940                 


Gln Gly Cys Ser Cys Glu Val Cys Gly Phe Ser Cys His Ile Xaa Cys 
945                 950                 955                 960 


Val Asn Lys Ala Pro Xaa Xaa Cys Pro Val Pro Pro Glu Gln Xaa Lys 
                965                 970                 975     


Gly Pro Leu Gly Ile Asp Pro Gln Lys Gly Ile Gly Xaa Ala Tyr Glu 
            980                 985                 990         


Gly His Val Arg Ile Pro Lys Pro  Ala Gly Val Lys Lys  Gly Trp Gln 
        995                 1000                 1005             


Arg Ala  Leu Ala Ile Val Cys  Asp Phe Lys Leu Phe  Leu Tyr Asp 
    1010                 1015                 1020             


Ile Ala  Glu Gly Lys Ala Ser  Gln Pro Ser Val Val  Ile Ser Gln 
    1025                 1030                 1035             


Val Ile  Asp Met Arg Asp Glu  Glu Phe Ser Val Ser  Ser Val Leu 
    1040                 1045                 1050             


Ala Ser  Asp Val Ile His Ala  Ser Arg Lys Asp Ile  Pro Cys Ile 
    1055                 1060                 1065             


Phe Arg  Val Xaa Ala Ser Gln  Leu Ser Ala Ser Asn  Asn Lys Cys 
    1070                 1075                 1080             


Ser Ile  Leu Met Leu Ala Asp  Xaa Glu Asn Glu Lys  Asn Lys Trp 
    1085                 1090                 1095             


Val Gly  Val Leu Ser Glu Leu  His Lys Ile Leu Lys  Lys Asn Lys 
    1100                 1105                 1110             


Phe Arg  Asp Arg Ser Val Tyr  Val Pro Lys Glu Ala  Tyr Asp Ser 
    1115                 1120                 1125             


Xaa Leu  Pro Leu Ile Lys Xaa  Xaa Gln Ala Ala Ala  Ile Ile Asp 
    1130                 1135                 1140             


His Glu  Arg Ile Ala Leu Gly  Asn Glu Glu Gly Leu  Phe Val Val 
    1145                 1150                 1155             


His Val  Xaa Lys Asp Glu Ile  Ile Arg Val Gly Asp  Asn Lys Lys 
    1160                 1165                 1170             


Ile His  Gln Ile Glu Leu Ile  Pro Asn Asp Gln Leu  Val Ala Val 
    1175                 1180                 1185             


Ile Ser  Gly Arg Asn Arg His  Val Arg Leu Phe Pro  Met Ser Ala 
    1190                 1195                 1200             


Leu Asp  Gly Arg Glu Xaa Asp  Phe Tyr Lys Leu Ser  Glu Xaa Lys 
    1205                 1210                 1215             


Gly Cys  Gln Xaa Val Xaa Ser  Gly Lys Val Arg His  Gly Ala Leu 
    1220                 1225                 1230             


Xaa Cys  Leu Cys Val Ala Met  Lys Arg Gln Val Leu  Cys Tyr Glu 
    1235                 1240                 1245             


Leu Phe  Gln Ser Lys Xaa Arg  His Arg Lys Phe Lys  Glu Ile Gln 
    1250                 1255                 1260             


Val Pro  Tyr Asn Val Gln Trp  Met Ala Ile Phe Ser  Glu Gln Leu 
    1265                 1270                 1275             


Cys Val  Gly Phe Gln Ser Gly  Phe Leu Arg Tyr Pro  Leu Asn Gly 
    1280                 1285                 1290             


Glu Gly  Asn Pro Tyr Ser Met  Leu His Ser Asn Asp  His Xaa Leu 
    1295                 1300                 1305             


Ser Phe  Ile Ala His Gln Pro  Met Asp Ala Ile Cys  Ala Val Glu 
    1310                 1315                 1320             


Ile Ser  Ser Lys Glu Tyr Leu  Leu Cys Phe Asn Ser  Ile Gly Ile 
    1325                 1330                 1335             


Tyr Xaa  Asp Cys Gln Gly Arg  Arg Ser Arg Gln Gln  Glu Leu Met 
    1340                 1345                 1350             


Trp Pro  Ala Asn Pro Ser Ser  Cys Cys Tyr Asn Ala  Pro Tyr Leu 
    1355                 1360                 1365             


Ser Val  Tyr Ser Glu Asn Ala  Val Asp Ile Phe Asp  Val Asn Ser 
    1370                 1375                 1380             


Met Glu  Trp Ile Gln Xaa Leu  Pro Leu Lys Lys Val  Arg Pro Leu 
    1385                 1390                 1395             


Asn Asn  Glu Gly Ser Leu Asn  Leu Leu Gly Leu Glu  Xaa Ile Arg 
    1400                 1405                 1410             


Leu Ile  Tyr Phe Lys Asn Lys  Met Ala Glu Gly Asp  Glu Leu Val 
    1415                 1420                 1425             


Val Pro  Glu Xaa Ser Asp Asn  Ser Arg Lys Gln Met  Val Arg Asn 
    1430                 1435                 1440             


Ile Asn  Asn Lys Arg Arg Tyr  Ser Phe Arg Val Pro  Glu Glu Glu 
    1445                 1450                 1455             


Arg Met  Gln Gln Arg Arg Glu  Met Leu Arg Asp Pro  Glu Met Arg 
    1460                 1465                 1470             


Asn Lys  Leu Ile Ser Asn Pro  Xaa Asn Phe Asn His  Ile Ala His 
    1475                 1480                 1485             


Met Gly  Pro Gly Asp Gly Ile  Gln Ile Leu Lys Asp  Leu Pro Met 
    1490                 1495                 1500             


Asn Pro  Arg Pro Gln Glu Ser  Arg Xaa Val Phe Ser  Gly Ser Val 
    1505                 1510                 1515             


Ser Ile  Pro Ser Ile Xaa Lys  Ser Arg Pro Glu Pro  Gly Arg Ser 
    1520                 1525                 1530             


Met Ser  Ala Ser Ser Gly Leu  Ser Ala Arg Ser Ser  Ala Gln Asn 
    1535                 1540                 1545             


Gly Ser  Ala Leu Lys Arg Glu  Phe Ser Gly Gly Ser  Tyr Ser Ala 
    1550                 1555                 1560             


Lys Arg  Gln Pro Met Pro Ser  Pro Ser Glu Gly Ser  Leu Ser Ser 
    1565                 1570                 1575             


Gly Gly  Met Asp Gln Gly Ser  Asp Ala Pro Ala Arg  Asp Phe Asp 
    1580                 1585                 1590             


Gly Glu  Asp Ser Asp Ser Pro  Arg His Ser Xaa Ala  Ser Asn Ser 
    1595                 1600                 1605             


Ser Asn  Leu Ser Ser Pro Pro  Ser Pro Ala Ser Pro  Arg Lys Xaa 
    1610                 1615                 1620             


Lys Ser  Leu Ser Leu Glu Ser  Xaa Asp Arg Gly Ser  Trp Asp Pro 
    1625                 1630                 1635             


<210> 5643
<211> 1699
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1152)..(1152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1190)..(1190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1222)..(1222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1270)..(1270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1278)..(1278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1315)..(1315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1368)..(1368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1450)..(1450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1493)..(1493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1585)..(1585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1665)..(1665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1684)..(1684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1692)..(1692)
<223> Selenocysteine

<400> 5643
Met Ser Gly Glu Val Arg Leu Arg Gln Leu Glu Gln Phe Ile Leu Asp 
1               5                   10                  15      


Gly Pro Ala Gln Xaa Asn Gly Gln Cys Phe Ser Val Glu Xaa Leu Leu 
            20                  25                  30          


Asp Ile Leu Ile Cys Leu Tyr Asp Glu Cys Asn Asn Ser Pro Leu Arg 
        35                  40                  45              


Arg Glu Lys Asn Ile Leu Glu Tyr Leu Glu Trp Ala Lys Pro Phe Xaa 
    50                  55                  60                  


Ser Lys Val Lys Gln Met Arg Leu His Arg Glu Asp Phe Glu Ile Leu 
65                  70                  75                  80  


Lys Val Ile Gly Arg Gly Ala Phe Gly Glu Val Ala Val Val Lys Leu 
                85                  90                  95      


Lys Asn Ala Asp Lys Val Phe Ala Met Lys Ile Leu Asn Lys Trp Glu 
            100                 105                 110         


Met Leu Lys Arg Ala Glu Xaa Ala Cys Phe Arg Glu Glu Arg Asp Val 
        115                 120                 125             


Leu Val Asn Gly Asp Asn Lys Trp Ile Xaa Xaa Leu His Tyr Ala Phe 
    130                 135                 140                 


Gln Asp Asp Asn Asn Leu Tyr Leu Val Met Asp Tyr Tyr Val Gly Gly 
145                 150                 155                 160 


Asp Leu Leu Xaa Leu Leu Ser Lys Phe Glu Asp Arg Leu Pro Glu Asp 
                165                 170                 175     


Met Ala Arg Phe Tyr Leu Ala Glu Met Val Ile Ala Ile Asp Ser Val 
            180                 185                 190         


His Gln Leu His Tyr Val His Arg Asp Ile Lys Pro Asp Asn Ile Leu 
        195                 200                 205             


Met Asp Met Asn Gly His Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu 
    210                 215                 220                 


Lys Leu Met Glu Asp Gly Xaa Val Gln Ser Ser Val Ala Val Gly Xaa 
225                 230                 235                 240 


Pro Asp Tyr Ile Ser Pro Glu Ile Leu Gln Ala Met Glu Asp Gly Lys 
                245                 250                 255     


Gly Arg Tyr Gly Pro Glu Cys Asp Trp Trp Ser Leu Gly Val Cys Met 
            260                 265                 270         


Tyr Glu Met Leu Tyr Gly Glu Xaa Pro Phe Tyr Ala Glu Ser Leu Val 
        275                 280                 285             


Glu Xaa Tyr Gly Lys Ile Met Asn His Lys Glu Arg Phe Gln Phe Pro 
    290                 295                 300                 


Ala Gln Val Xaa Asp Val Ser Glu Asn Ala Lys Asp Leu Ile Arg Arg 
305                 310                 315                 320 


Leu Ile Cys Ser Arg Glu His Arg Leu Gly Gln Asn Gly Ile Glu Asp 
                325                 330                 335     


Phe Lys Lys His Pro Phe Phe Ser Gly Ile Asp Trp Asp Asn Ile Arg 
            340                 345                 350         


Asn Cys Glu Ala Pro Tyr Ile Pro Glu Val Ser Ser Pro Xaa Asp Xaa 
        355                 360                 365             


Ser Asn Phe Asp Val Asp Asp Asp Cys Leu Lys Asn Ser Glu Xaa Met 
    370                 375                 380                 


Pro Pro Pro Xaa His Xaa Ala Phe Ser Gly His His Leu Pro Phe Val 
385                 390                 395                 400 


Gly Phe Xaa Tyr Xaa Ser Ser Cys Val Leu Ser Asp Arg Ser Cys Leu 
                405                 410                 415     


Arg Val Xaa Ala Gly Pro Xaa Ser Leu Asp Leu Asp Val Asn Val Gln 
            420                 425                 430         


Arg Xaa Leu Asp Asn Asn Leu Ala Xaa Glu Ala Tyr Glu Arg Arg Ile 
        435                 440                 445             


Lys Arg Leu Glu Gln Glu Lys Leu Glu Leu Ser Arg Lys Leu Gln Glu 
    450                 455                 460                 


Ser Xaa Gln Xaa Val Gln Ala Leu Gln Tyr Ser Xaa Val Asp Gly Pro 
465                 470                 475                 480 


Leu Xaa Ala Ser Lys Asp Leu Glu Ile Lys Asn Leu Lys Glu Glu Ile 
                485                 490                 495     


Glu Lys Leu Arg Lys Gln Val Xaa Glu Ser Ser His Leu Glu Gln Gln 
            500                 505                 510         


Leu Glu Glu Ala Asn Ala Val Arg Gln Glu Leu Asp Asp Ala Phe Arg 
        515                 520                 525             


Gln Ile Lys Ala Tyr Glu Lys Gln Ile Lys Xaa Leu Gln Gln Glu Arg 
    530                 535                 540                 


Glu Asp Leu Asn Lys Glu Leu Val Gln Ala Ser Glu Arg Leu Lys Asn 
545                 550                 555                 560 


Gln Ser Lys Glu Leu Lys Asp Ala His Cys Gln Arg Lys Leu Ala Met 
                565                 570                 575     


Gln Glu Phe Met Glu Ile Asn Glu Arg Leu Xaa Glu Leu His Xaa Gln 
            580                 585                 590         


Lys Gln Lys Leu Ala Arg His Val Arg Asp Lys Glu Glu Glu Val Asp 
        595                 600                 605             


Leu Val Met Gln Lys Val Glu Ser Leu Arg Gln Glu Leu Arg Arg Xaa 
    610                 615                 620                 


Glu Arg Ala Lys Lys Glu Leu Glu Val His Xaa Glu Ala Leu Ala Ala 
625                 630                 635                 640 


Glu Ala Ser Lys Asp Arg Lys Leu Arg Glu Gln Ser Glu His Tyr Ser 
                645                 650                 655     


Lys Gln Leu Glu Asn Glu Leu Glu Gly Leu Lys Gln Lys Gln Ile Ser 
            660                 665                 670         


Tyr Ser Pro Gly Val Cys Ser Ile Glu His Gln Gln Glu Ile Xaa Lys 
        675                 680                 685             


Leu Lys Xaa Asp Leu Glu Lys Lys Ser Ile Phe Tyr Glu Glu Glu Leu 
    690                 695                 700                 


Ser Lys Arg Glu Gly Ile His Ala Asn Glu Ile Lys Asn Leu Lys Lys 
705                 710                 715                 720 


Glu Leu His Asp Ser Glu Gly Gln Gln Leu Ala Leu Asn Lys Glu Ile 
                725                 730                 735     


Met Ile Leu Lys Asp Lys Leu Glu Lys Xaa Arg Arg Glu Ser Gln Ser 
            740                 745                 750         


Glu Arg Glu Glu Phe Glu Ser Glu Phe Lys Gln Gln Tyr Glu Arg Glu 
        755                 760                 765             


Lys Val Leu Leu Xaa Glu Glu Asn Lys Lys Leu Xaa Ser Glu Leu Asp 
    770                 775                 780                 


Lys Leu Xaa Xaa Leu Tyr Glu Asn Leu Ser Ile His Asn Gln Gln Leu 
785                 790                 795                 800 


Glu Glu Glu Val Lys Asp Leu Ala Asp Lys Lys Glu Ser Val Ala His 
                805                 810                 815     


Trp Glu Ala Gln Ile Xaa Glu Ile Ile Gln Trp Val Ser Asp Glu Lys 
            820                 825                 830         


Asp Ala Arg Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Xaa Glu Glu 
        835                 840                 845             


Leu Glu Ala Leu Arg Asn Ser Ser Leu Gly Xaa Arg Ala Xaa Asp Met 
    850                 855                 860                 


Pro Trp Lys Met Arg Arg Phe Ala Lys Leu Asp Met Ser Ala Arg Leu 
865                 870                 875                 880 


Glu Leu Gln Ser Ala Leu Asp Ala Glu Ile Arg Ala Lys Gln Ala Ile 
                885                 890                 895     


Gln Glu Glu Leu Asn Lys Val Lys Ala Ser Asn Ile Ile Xaa Glu Cys 
            900                 905                 910         


Lys Leu Lys Asp Ser Glu Lys Lys Asn Leu Glu Leu Leu Ser Glu Ile 
        915                 920                 925             


Glu Gln Leu Ile Lys Asp Xaa Glu Glu Leu Arg Ser Glu Lys Ala Ser 
    930                 935                 940                 


Lys Gly Arg Arg Xaa Val Asp Ser Xaa Pro Leu Ser Val His Xaa Pro 
945                 950                 955                 960 


Xaa Leu Arg Lys Lys Gly Cys Pro Gly Ser Xaa Gly Phe Pro Pro Lys 
                965                 970                 975     


Arg Lys Xaa His Gln Phe Phe Val Lys Ser Phe Xaa Xaa Pro Xaa Lys 
            980                 985                 990         


Cys His Gln Cys Xaa Ser Leu Met  Val Gly Leu Ile Arg  Gln Gly Cys 
        995                 1000                 1005             


Ser Cys  Glu Val Cys Gly Phe  Ser Cys His Ile Xaa  Cys Val Asn 
    1010                 1015                 1020             


Lys Ala  Pro Xaa Xaa Cys Pro  Val Pro Pro Glu Gln  Xaa Lys Gly 
    1025                 1030                 1035             


Pro Leu  Gly Ile Asp Pro Gln  Lys Gly Ile Gly Xaa  Ala Tyr Glu 
    1040                 1045                 1050             


Gly His  Val Arg Ile Pro Lys  Pro Ala Gly Val Lys  Lys Gly Trp 
    1055                 1060                 1065             


Gln Arg  Ala Leu Ala Ile Val  Cys Asp Phe Lys Leu  Phe Leu Tyr 
    1070                 1075                 1080             


Asp Ile  Ala Glu Gly Lys Ala  Ser Gln Pro Ser Val  Val Ile Ser 
    1085                 1090                 1095             


Gln Val  Ile Asp Met Arg Asp  Glu Glu Phe Ser Val  Ser Ser Val 
    1100                 1105                 1110             


Leu Ala  Ser Asp Val Ile His  Ala Ser Arg Lys Asp  Ile Pro Cys 
    1115                 1120                 1125             


Ile Phe  Arg Val Xaa Ala Ser  Gln Leu Ser Ala Ser  Asn Asn Lys 
    1130                 1135                 1140             


Cys Ser  Ile Leu Met Leu Ala  Asp Xaa Glu Asn Glu  Lys Asn Lys 
    1145                 1150                 1155             


Trp Val  Gly Val Leu Ser Glu  Leu His Lys Ile Leu  Lys Lys Asn 
    1160                 1165                 1170             


Lys Phe  Arg Asp Arg Ser Val  Tyr Val Pro Lys Glu  Ala Tyr Asp 
    1175                 1180                 1185             


Ser Xaa  Leu Pro Leu Ile Lys  Xaa Xaa Gln Ala Ala  Ala Ile Ile 
    1190                 1195                 1200             


Asp His  Glu Arg Ile Ala Leu  Gly Asn Glu Glu Gly  Leu Phe Val 
    1205                 1210                 1215             


Val His  Val Xaa Lys Asp Glu  Ile Ile Arg Val Gly  Asp Asn Lys 
    1220                 1225                 1230             


Lys Ile  His Gln Ile Glu Leu  Ile Pro Asn Asp Gln  Leu Val Ala 
    1235                 1240                 1245             


Val Ile  Ser Gly Arg Asn Arg  His Val Arg Leu Phe  Pro Met Ser 
    1250                 1255                 1260             


Ala Leu  Asp Gly Arg Glu Xaa  Asp Phe Tyr Lys Leu  Ser Glu Xaa 
    1265                 1270                 1275             


Lys Gly  Cys Gln Xaa Val Xaa  Ser Gly Lys Val Arg  His Gly Ala 
    1280                 1285                 1290             


Leu Xaa  Cys Leu Cys Val Ala  Met Lys Arg Gln Val  Leu Cys Tyr 
    1295                 1300                 1305             


Glu Leu  Phe Gln Ser Lys Xaa  Arg His Arg Lys Phe  Lys Glu Ile 
    1310                 1315                 1320             


Gln Val  Pro Tyr Asn Val Gln  Trp Met Ala Ile Phe  Ser Glu Gln 
    1325                 1330                 1335             


Leu Cys  Val Gly Phe Gln Ser  Gly Phe Leu Arg Tyr  Pro Leu Asn 
    1340                 1345                 1350             


Gly Glu  Gly Asn Pro Tyr Ser  Met Leu His Ser Asn  Asp His Xaa 
    1355                 1360                 1365             


Leu Ser  Phe Ile Ala His Gln  Pro Met Asp Ala Ile  Cys Ala Val 
    1370                 1375                 1380             


Glu Ile  Ser Ser Lys Glu Tyr  Leu Leu Cys Phe Asn  Ser Ile Gly 
    1385                 1390                 1395             


Ile Tyr  Xaa Asp Cys Gln Gly  Arg Arg Ser Arg Gln  Gln Glu Leu 
    1400                 1405                 1410             


Met Trp  Pro Ala Asn Pro Ser  Ser Cys Cys Tyr Asn  Ala Pro Tyr 
    1415                 1420                 1425             


Leu Ser  Val Tyr Ser Glu Asn  Ala Val Asp Ile Phe  Asp Val Asn 
    1430                 1435                 1440             


Ser Met  Glu Trp Ile Gln Xaa  Leu Pro Leu Lys Lys  Val Arg Pro 
    1445                 1450                 1455             


Leu Asn  Asn Glu Gly Ser Leu  Asn Leu Leu Gly Leu  Glu Xaa Ile 
    1460                 1465                 1470             


Arg Leu  Ile Tyr Phe Lys Asn  Lys Met Ala Glu Gly  Asp Glu Leu 
    1475                 1480                 1485             


Val Val  Pro Glu Xaa Ser Asp  Asn Ser Arg Lys Gln  Met Val Arg 
    1490                 1495                 1500             


Asn Ile  Asn Asn Lys Arg Arg  Tyr Ser Phe Arg Val  Pro Glu Glu 
    1505                 1510                 1515             


Glu Arg  Met Gln Gln Arg Arg  Glu Met Leu Arg Asp  Pro Glu Met 
    1520                 1525                 1530             


Arg Asn  Lys Leu Ile Ser Asn  Pro Xaa Asn Phe Asn  His Ile Ala 
    1535                 1540                 1545             


His Met  Gly Pro Gly Asp Gly  Ile Gln Ile Leu Lys  Asp Leu Pro 
    1550                 1555                 1560             


Met Asn  Pro Arg Pro Gln Glu  Ser Arg Xaa Val Phe  Ser Gly Ser 
    1565                 1570                 1575             


Val Ser  Ile Pro Ser Ile Xaa  Lys Ser Arg Pro Glu  Pro Gly Arg 
    1580                 1585                 1590             


Ser Met  Ser Ala Ser Ser Gly  Leu Ser Ala Arg Ser  Ser Ala Gln 
    1595                 1600                 1605             


Asn Gly  Ser Ala Leu Lys Arg  Glu Phe Ser Gly Gly  Ser Tyr Ser 
    1610                 1615                 1620             


Ala Lys  Arg Gln Pro Met Pro  Ser Pro Ser Glu Gly  Ser Leu Ser 
    1625                 1630                 1635             


Ser Gly  Gly Met Asp Gln Gly  Ser Asp Ala Pro Ala  Arg Asp Phe 
    1640                 1645                 1650             


Asp Gly  Glu Asp Ser Asp Ser  Pro Arg His Ser Xaa  Ala Ser Asn 
    1655                 1660                 1665             


Ser Ser  Asn Leu Ser Ser Pro  Pro Ser Pro Ala Ser  Pro Arg Lys 
    1670                 1675                 1680             


Xaa Lys  Ser Leu Ser Leu Glu  Ser Xaa Asp Arg Gly  Ser Trp Asp 
    1685                 1690                 1695             


Pro 
    


<210> 5644
<211> 1719
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1017)..(1017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1298)..(1298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1315)..(1315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1388)..(1388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1421)..(1421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1470)..(1470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1492)..(1492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1513)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1562)..(1562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1593)..(1593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1605)..(1605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1685)..(1685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1704)..(1704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1712)..(1712)
<223> Selenocysteine

<400> 5644
Met Ser Gly Glu Val Arg Leu Arg Gln Leu Glu Gln Phe Ile Leu Asp 
1               5                   10                  15      


Gly Pro Ala Gln Xaa Asn Gly Gln Cys Phe Ser Val Glu Xaa Leu Leu 
            20                  25                  30          


Asp Ile Leu Ile Cys Leu Tyr Asp Glu Cys Asn Asn Ser Pro Leu Arg 
        35                  40                  45              


Arg Glu Lys Asn Ile Leu Glu Tyr Leu Glu Trp Ala Lys Pro Phe Xaa 
    50                  55                  60                  


Ser Lys Val Lys Gln Met Arg Leu His Arg Glu Asp Phe Glu Ile Leu 
65                  70                  75                  80  


Lys Val Ile Gly Arg Gly Ala Phe Gly Glu Val Ala Val Val Lys Leu 
                85                  90                  95      


Lys Asn Ala Asp Lys Val Phe Ala Met Lys Ile Leu Asn Lys Trp Glu 
            100                 105                 110         


Met Leu Lys Arg Ala Glu Xaa Ala Cys Phe Arg Glu Glu Arg Asp Val 
        115                 120                 125             


Leu Val Asn Gly Asp Asn Lys Trp Ile Xaa Xaa Leu His Tyr Ala Phe 
    130                 135                 140                 


Gln Asp Asp Asn Asn Leu Tyr Leu Val Met Asp Tyr Tyr Val Gly Gly 
145                 150                 155                 160 


Asp Leu Leu Xaa Leu Leu Ser Lys Phe Glu Asp Arg Leu Pro Glu Asp 
                165                 170                 175     


Met Ala Arg Phe Tyr Leu Ala Glu Met Val Ile Ala Ile Asp Ser Val 
            180                 185                 190         


His Gln Leu His Tyr Val His Arg Asp Ile Lys Pro Asp Asn Ile Leu 
        195                 200                 205             


Met Asp Met Asn Gly His Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu 
    210                 215                 220                 


Lys Leu Met Glu Asp Gly Xaa Val Gln Ser Ser Val Ala Val Gly Xaa 
225                 230                 235                 240 


Pro Asp Tyr Ile Ser Pro Glu Ile Leu Gln Ala Met Glu Asp Gly Lys 
                245                 250                 255     


Gly Arg Tyr Gly Pro Glu Cys Asp Trp Trp Ser Leu Gly Val Cys Met 
            260                 265                 270         


Tyr Glu Met Leu Tyr Gly Glu Xaa Pro Phe Tyr Ala Glu Ser Leu Val 
        275                 280                 285             


Glu Xaa Tyr Gly Lys Ile Met Asn His Lys Glu Arg Phe Gln Phe Pro 
    290                 295                 300                 


Ala Gln Val Xaa Asp Val Ser Glu Asn Ala Lys Asp Leu Ile Arg Arg 
305                 310                 315                 320 


Leu Ile Cys Ser Arg Glu His Arg Leu Gly Gln Asn Gly Ile Glu Asp 
                325                 330                 335     


Phe Lys Lys His Pro Phe Phe Ser Gly Ile Asp Trp Asp Asn Ile Arg 
            340                 345                 350         


Asn Cys Glu Ala Pro Tyr Ile Pro Glu Val Ser Ser Pro Xaa Asp Xaa 
        355                 360                 365             


Ser Asn Phe Asp Val Asp Asp Asp Cys Leu Lys Asn Ser Glu Xaa Met 
    370                 375                 380                 


Pro Pro Pro Xaa His Xaa Ala Phe Ser Gly His His Leu Pro Phe Val 
385                 390                 395                 400 


Gly Phe Xaa Tyr Xaa Ser Ser Cys Val Leu Ser Asp Arg Ser Cys Leu 
                405                 410                 415     


Arg Val Xaa Ala Gly Pro Xaa Ser Leu Asp Leu Asp Val Asn Val Gln 
            420                 425                 430         


Arg Xaa Leu Asp Asn Asn Leu Ala Xaa Glu Ala Tyr Glu Arg Arg Ile 
        435                 440                 445             


Lys Arg Leu Glu Gln Glu Lys Leu Glu Leu Ser Arg Lys Leu Gln Glu 
    450                 455                 460                 


Ser Xaa Gln Xaa Val Gln Ala Leu Gln Tyr Ser Xaa Val Asp Gly Pro 
465                 470                 475                 480 


Leu Xaa Ala Ser Lys Asp Leu Glu Ile Lys Asn Leu Lys Glu Glu Ile 
                485                 490                 495     


Glu Lys Leu Arg Lys Gln Val Xaa Glu Ser Ser His Leu Glu Gln Gln 
            500                 505                 510         


Leu Glu Glu Ala Asn Ala Val Arg Gln Glu Leu Asp Asp Ala Phe Arg 
        515                 520                 525             


Gln Ile Lys Ala Tyr Glu Lys Gln Ile Lys Xaa Leu Gln Gln Glu Arg 
    530                 535                 540                 


Glu Asp Leu Asn Lys Glu Leu Val Gln Ala Ser Glu Arg Leu Lys Asn 
545                 550                 555                 560 


Gln Ser Lys Glu Leu Lys Asp Ala His Cys Gln Arg Lys Leu Ala Met 
                565                 570                 575     


Gln Glu Phe Met Glu Ile Asn Glu Arg Leu Xaa Glu Leu His Xaa Gln 
            580                 585                 590         


Lys Gln Lys Leu Ala Arg His Val Arg Asp Lys Glu Glu Glu Val Asp 
        595                 600                 605             


Leu Val Met Gln Lys Val Glu Ser Leu Arg Gln Glu Leu Arg Arg Xaa 
    610                 615                 620                 


Glu Arg Ala Lys Lys Glu Leu Glu Val His Xaa Glu Ala Leu Ala Ala 
625                 630                 635                 640 


Glu Ala Ser Lys Asp Arg Lys Leu Arg Glu Gln Ser Glu His Tyr Ser 
                645                 650                 655     


Lys Gln Leu Glu Asn Glu Leu Glu Gly Leu Lys Gln Lys Gln Ile Ser 
            660                 665                 670         


Tyr Ser Pro Gly Val Cys Ser Ile Glu His Gln Gln Glu Ile Xaa Lys 
        675                 680                 685             


Leu Lys Xaa Asp Leu Glu Lys Lys Ser Ile Phe Tyr Glu Glu Glu Leu 
    690                 695                 700                 


Ser Lys Arg Glu Gly Ile His Ala Asn Glu Ile Lys Asn Leu Lys Lys 
705                 710                 715                 720 


Glu Leu His Asp Ser Glu Gly Gln Gln Leu Ala Leu Asn Lys Glu Ile 
                725                 730                 735     


Met Ile Leu Lys Asp Lys Leu Glu Lys Xaa Arg Arg Glu Ser Gln Ser 
            740                 745                 750         


Glu Arg Glu Glu Phe Glu Ser Glu Phe Lys Gln Gln Tyr Glu Arg Glu 
        755                 760                 765             


Lys Val Leu Leu Xaa Glu Glu Asn Lys Lys Leu Xaa Ser Glu Leu Asp 
    770                 775                 780                 


Lys Leu Xaa Xaa Leu Tyr Glu Asn Leu Ser Ile His Asn Gln Gln Leu 
785                 790                 795                 800 


Glu Glu Glu Val Lys Asp Leu Ala Asp Lys Lys Glu Ser Val Ala His 
                805                 810                 815     


Trp Glu Ala Gln Ile Xaa Glu Ile Ile Gln Trp Val Ser Asp Glu Lys 
            820                 825                 830         


Asp Ala Arg Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Xaa Glu Glu 
        835                 840                 845             


Leu Glu Ala Leu Arg Asn Ser Ser Leu Gly Xaa Arg Ala Xaa Asp Met 
    850                 855                 860                 


Pro Trp Lys Met Arg Arg Phe Ala Lys Leu Asp Met Ser Ala Arg Leu 
865                 870                 875                 880 


Glu Leu Gln Ser Ala Leu Asp Ala Glu Ile Arg Ala Lys Gln Ala Ile 
                885                 890                 895     


Gln Glu Glu Leu Asn Lys Val Lys Ala Ser Asn Ile Ile Xaa Glu Cys 
            900                 905                 910         


Lys Leu Lys Asp Ser Glu Lys Lys Asn Leu Glu Leu Leu Ser Glu Ile 
        915                 920                 925             


Glu Gln Leu Ile Lys Asp Xaa Glu Glu Leu Arg Ser Glu Lys Gly Ile 
    930                 935                 940                 


Glu His Gln Asp Ser Gln His Ser Phe Leu Ala Phe Leu Asn Xaa Pro 
945                 950                 955                 960 


Xaa Asp Ala Leu Asp Gln Phe Glu Xaa Val Asp Ser Xaa Pro Leu Ser 
                965                 970                 975     


Val His Xaa Pro Xaa Leu Arg Lys Lys Gly Cys Pro Gly Ser Xaa Gly 
            980                 985                 990         


Phe Pro Pro Lys Arg Lys Xaa His  Gln Phe Phe Val Lys  Ser Phe Xaa 
        995                 1000                 1005             


Xaa Pro  Xaa Lys Cys His Gln  Cys Xaa Ser Leu Met  Val Gly Leu 
    1010                 1015                 1020             


Ile Arg  Gln Gly Cys Ser Cys  Glu Val Cys Gly Phe  Ser Cys His 
    1025                 1030                 1035             


Ile Xaa  Cys Val Asn Lys Ala  Pro Xaa Xaa Cys Pro  Val Pro Pro 
    1040                 1045                 1050             


Glu Gln  Xaa Lys Gly Pro Leu  Gly Ile Asp Pro Gln  Lys Gly Ile 
    1055                 1060                 1065             


Gly Xaa  Ala Tyr Glu Gly His  Val Arg Ile Pro Lys  Pro Ala Gly 
    1070                 1075                 1080             


Val Lys  Lys Gly Trp Gln Arg  Ala Leu Ala Ile Val  Cys Asp Phe 
    1085                 1090                 1095             


Lys Leu  Phe Leu Tyr Asp Ile  Ala Glu Gly Lys Ala  Ser Gln Pro 
    1100                 1105                 1110             


Ser Val  Val Ile Ser Gln Val  Ile Asp Met Arg Asp  Glu Glu Phe 
    1115                 1120                 1125             


Ser Val  Ser Ser Val Leu Ala  Ser Asp Val Ile His  Ala Ser Arg 
    1130                 1135                 1140             


Lys Asp  Ile Pro Cys Ile Phe  Arg Val Xaa Ala Ser  Gln Leu Ser 
    1145                 1150                 1155             


Ala Ser  Asn Asn Lys Cys Ser  Ile Leu Met Leu Ala  Asp Xaa Glu 
    1160                 1165                 1170             


Asn Glu  Lys Asn Lys Trp Val  Gly Val Leu Ser Glu  Leu His Lys 
    1175                 1180                 1185             


Ile Leu  Lys Lys Asn Lys Phe  Arg Asp Arg Ser Val  Tyr Val Pro 
    1190                 1195                 1200             


Lys Glu  Ala Tyr Asp Ser Xaa  Leu Pro Leu Ile Lys  Xaa Xaa Gln 
    1205                 1210                 1215             


Ala Ala  Ala Ile Ile Asp His  Glu Arg Ile Ala Leu  Gly Asn Glu 
    1220                 1225                 1230             


Glu Gly  Leu Phe Val Val His  Val Xaa Lys Asp Glu  Ile Ile Arg 
    1235                 1240                 1245             


Val Gly  Asp Asn Lys Lys Ile  His Gln Ile Glu Leu  Ile Pro Asn 
    1250                 1255                 1260             


Asp Gln  Leu Val Ala Val Ile  Ser Gly Arg Asn Arg  His Val Arg 
    1265                 1270                 1275             


Leu Phe  Pro Met Ser Ala Leu  Asp Gly Arg Glu Xaa  Asp Phe Tyr 
    1280                 1285                 1290             


Lys Leu  Ser Glu Xaa Lys Gly  Cys Gln Xaa Val Xaa  Ser Gly Lys 
    1295                 1300                 1305             


Val Arg  His Gly Ala Leu Xaa  Cys Leu Cys Val Ala  Met Lys Arg 
    1310                 1315                 1320             


Gln Val  Leu Cys Tyr Glu Leu  Phe Gln Ser Lys Xaa  Arg His Arg 
    1325                 1330                 1335             


Lys Phe  Lys Glu Ile Gln Val  Pro Tyr Asn Val Gln  Trp Met Ala 
    1340                 1345                 1350             


Ile Phe  Ser Glu Gln Leu Cys  Val Gly Phe Gln Ser  Gly Phe Leu 
    1355                 1360                 1365             


Arg Tyr  Pro Leu Asn Gly Glu  Gly Asn Pro Tyr Ser  Met Leu His 
    1370                 1375                 1380             


Ser Asn  Asp His Xaa Leu Ser  Phe Ile Ala His Gln  Pro Met Asp 
    1385                 1390                 1395             


Ala Ile  Cys Ala Val Glu Ile  Ser Ser Lys Glu Tyr  Leu Leu Cys 
    1400                 1405                 1410             


Phe Asn  Ser Ile Gly Ile Tyr  Xaa Asp Cys Gln Gly  Arg Arg Ser 
    1415                 1420                 1425             


Arg Gln  Gln Glu Leu Met Trp  Pro Ala Asn Pro Ser  Ser Cys Cys 
    1430                 1435                 1440             


Tyr Asn  Ala Pro Tyr Leu Ser  Val Tyr Ser Glu Asn  Ala Val Asp 
    1445                 1450                 1455             


Ile Phe  Asp Val Asn Ser Met  Glu Trp Ile Gln Xaa  Leu Pro Leu 
    1460                 1465                 1470             


Lys Lys  Val Arg Pro Leu Asn  Asn Glu Gly Ser Leu  Asn Leu Leu 
    1475                 1480                 1485             


Gly Leu  Glu Xaa Ile Arg Leu  Ile Tyr Phe Lys Asn  Lys Met Ala 
    1490                 1495                 1500             


Glu Gly  Asp Glu Leu Val Val  Pro Glu Xaa Ser Asp  Asn Ser Arg 
    1505                 1510                 1515             


Lys Gln  Met Val Arg Asn Ile  Asn Asn Lys Arg Arg  Tyr Ser Phe 
    1520                 1525                 1530             


Arg Val  Pro Glu Glu Glu Arg  Met Gln Gln Arg Arg  Glu Met Leu 
    1535                 1540                 1545             


Arg Asp  Pro Glu Met Arg Asn  Lys Leu Ile Ser Asn  Pro Xaa Asn 
    1550                 1555                 1560             


Phe Asn  His Ile Ala His Met  Gly Pro Gly Asp Gly  Ile Gln Ile 
    1565                 1570                 1575             


Leu Lys  Asp Leu Pro Met Asn  Pro Arg Pro Gln Glu  Ser Arg Xaa 
    1580                 1585                 1590             


Val Phe  Ser Gly Ser Val Ser  Ile Pro Ser Ile Xaa  Lys Ser Arg 
    1595                 1600                 1605             


Pro Glu  Pro Gly Arg Ser Met  Ser Ala Ser Ser Gly  Leu Ser Ala 
    1610                 1615                 1620             


Arg Ser  Ser Ala Gln Asn Gly  Ser Ala Leu Lys Arg  Glu Phe Ser 
    1625                 1630                 1635             


Gly Gly  Ser Tyr Ser Ala Lys  Arg Gln Pro Met Pro  Ser Pro Ser 
    1640                 1645                 1650             


Glu Gly  Ser Leu Ser Ser Gly  Gly Met Asp Gln Gly  Ser Asp Ala 
    1655                 1660                 1665             


Pro Ala  Arg Asp Phe Asp Gly  Glu Asp Ser Asp Ser  Pro Arg His 
    1670                 1675                 1680             


Ser Xaa  Ala Ser Asn Ser Ser  Asn Leu Ser Ser Pro  Pro Ser Pro 
    1685                 1690                 1695             


Ala Ser  Pro Arg Lys Xaa Lys  Ser Leu Ser Leu Glu  Ser Xaa Asp 
    1700                 1705                 1710             


Arg Gly  Ser Trp Asp Pro 
    1715                 


<210> 5645
<211> 1732
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1083)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1255)..(1255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1316)..(1316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1328)..(1328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1505)..(1505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1526)..(1526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1575)..(1575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1618)..(1618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1698)..(1698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1717)..(1717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1725)..(1725)
<223> Selenocysteine

<400> 5645
Met Ser Gly Glu Val Arg Leu Arg Gln Leu Glu Gln Phe Ile Leu Asp 
1               5                   10                  15      


Gly Pro Ala Gln Xaa Asn Gly Gln Cys Phe Ser Val Glu Xaa Leu Leu 
            20                  25                  30          


Asp Ile Leu Ile Cys Leu Tyr Asp Glu Cys Asn Asn Ser Pro Leu Arg 
        35                  40                  45              


Arg Glu Lys Asn Ile Leu Glu Tyr Leu Glu Trp Ala Lys Pro Phe Xaa 
    50                  55                  60                  


Ser Lys Val Lys Gln Met Arg Leu His Arg Glu Asp Phe Glu Ile Leu 
65                  70                  75                  80  


Lys Val Ile Gly Arg Gly Ala Phe Gly Glu Val Ala Val Val Lys Leu 
                85                  90                  95      


Lys Asn Ala Asp Lys Val Phe Ala Met Lys Ile Leu Asn Lys Trp Glu 
            100                 105                 110         


Met Leu Lys Arg Ala Glu Xaa Ala Cys Phe Arg Glu Glu Arg Asp Val 
        115                 120                 125             


Leu Val Asn Gly Asp Asn Lys Trp Ile Xaa Xaa Leu His Tyr Ala Phe 
    130                 135                 140                 


Gln Asp Asp Asn Asn Leu Tyr Leu Val Met Asp Tyr Tyr Val Gly Gly 
145                 150                 155                 160 


Asp Leu Leu Xaa Leu Leu Ser Lys Phe Glu Asp Arg Leu Pro Glu Asp 
                165                 170                 175     


Met Ala Arg Phe Tyr Leu Ala Glu Met Val Ile Ala Ile Asp Ser Val 
            180                 185                 190         


His Gln Leu His Tyr Val His Arg Asp Ile Lys Pro Asp Asn Ile Leu 
        195                 200                 205             


Met Asp Met Asn Gly His Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu 
    210                 215                 220                 


Lys Leu Met Glu Asp Gly Xaa Val Gln Ser Ser Val Ala Val Gly Xaa 
225                 230                 235                 240 


Pro Asp Tyr Ile Ser Pro Glu Ile Leu Gln Ala Met Glu Asp Gly Lys 
                245                 250                 255     


Gly Arg Tyr Gly Pro Glu Cys Asp Trp Trp Ser Leu Gly Val Cys Met 
            260                 265                 270         


Tyr Glu Met Leu Tyr Gly Glu Xaa Pro Phe Tyr Ala Glu Ser Leu Val 
        275                 280                 285             


Glu Xaa Tyr Gly Lys Ile Met Asn His Lys Glu Arg Phe Gln Phe Pro 
    290                 295                 300                 


Ala Gln Val Xaa Asp Val Ser Glu Asn Ala Lys Asp Leu Ile Arg Arg 
305                 310                 315                 320 


Leu Ile Cys Ser Arg Glu His Arg Leu Gly Gln Asn Gly Ile Glu Asp 
                325                 330                 335     


Phe Lys Lys His Pro Phe Phe Ser Gly Ile Asp Trp Asp Asn Ile Arg 
            340                 345                 350         


Asn Cys Glu Ala Pro Tyr Ile Pro Glu Val Ser Ser Pro Xaa Asp Xaa 
        355                 360                 365             


Ser Asn Phe Asp Val Asp Asp Asp Cys Leu Lys Asn Ser Glu Xaa Met 
    370                 375                 380                 


Pro Pro Pro Xaa His Xaa Ala Phe Ser Gly His His Leu Pro Phe Val 
385                 390                 395                 400 


Gly Phe Xaa Tyr Xaa Ser Ser Cys Val Leu Ser Asp Arg Ser Cys Leu 
                405                 410                 415     


Arg Val Xaa Ala Gly Pro Xaa Ser Leu Asp Leu Asp Val Asn Val Gln 
            420                 425                 430         


Arg Xaa Leu Asp Asn Asn Leu Ala Xaa Glu Ala Tyr Glu Arg Arg Ile 
        435                 440                 445             


Lys Arg Leu Glu Gln Glu Lys Leu Glu Leu Ser Arg Lys Leu Gln Glu 
    450                 455                 460                 


Ser Xaa Gln Xaa Val Gln Ala Leu Gln Tyr Ser Xaa Val Asp Gly Pro 
465                 470                 475                 480 


Leu Xaa Ala Ser Lys Asp Leu Glu Ile Lys Asn Leu Lys Glu Glu Ile 
                485                 490                 495     


Glu Lys Leu Arg Lys Gln Val Xaa Glu Ser Ser His Leu Glu Gln Gln 
            500                 505                 510         


Leu Glu Glu Ala Asn Ala Val Arg Gln Glu Leu Asp Asp Ala Phe Arg 
        515                 520                 525             


Gln Ile Lys Ala Tyr Glu Lys Gln Ile Lys Xaa Leu Gln Gln Glu Arg 
    530                 535                 540                 


Glu Asp Leu Asn Lys Glu Leu Val Gln Ala Ser Glu Arg Leu Lys Asn 
545                 550                 555                 560 


Gln Ser Lys Glu Leu Lys Asp Ala His Cys Gln Arg Lys Leu Ala Met 
                565                 570                 575     


Gln Glu Phe Met Glu Ile Asn Glu Arg Leu Xaa Glu Leu His Xaa Gln 
            580                 585                 590         


Lys Gln Lys Leu Ala Arg His Val Arg Asp Lys Glu Glu Glu Val Asp 
        595                 600                 605             


Leu Val Met Gln Lys Val Glu Ser Leu Arg Gln Glu Leu Arg Arg Xaa 
    610                 615                 620                 


Glu Arg Ala Lys Lys Glu Leu Glu Val His Xaa Glu Ala Leu Ala Ala 
625                 630                 635                 640 


Glu Ala Ser Lys Asp Arg Lys Leu Arg Glu Gln Ser Glu His Tyr Ser 
                645                 650                 655     


Lys Gln Leu Glu Asn Glu Leu Glu Gly Leu Lys Gln Lys Gln Ile Ser 
            660                 665                 670         


Tyr Ser Pro Gly Val Cys Ser Ile Glu His Gln Gln Glu Ile Xaa Lys 
        675                 680                 685             


Leu Lys Xaa Asp Leu Glu Lys Lys Ser Ile Phe Tyr Glu Glu Glu Leu 
    690                 695                 700                 


Ser Lys Arg Glu Gly Ile His Ala Asn Glu Ile Lys Asn Leu Lys Lys 
705                 710                 715                 720 


Glu Leu His Asp Ser Glu Gly Gln Gln Leu Ala Leu Asn Lys Glu Ile 
                725                 730                 735     


Met Ile Leu Lys Asp Lys Leu Glu Lys Xaa Arg Arg Glu Ser Gln Ser 
            740                 745                 750         


Glu Arg Glu Glu Phe Glu Ser Glu Phe Lys Gln Gln Tyr Glu Arg Glu 
        755                 760                 765             


Lys Val Leu Leu Xaa Glu Glu Asn Lys Lys Leu Xaa Ser Glu Leu Asp 
    770                 775                 780                 


Lys Leu Xaa Xaa Leu Tyr Glu Asn Leu Ser Ile His Asn Gln Gln Leu 
785                 790                 795                 800 


Glu Glu Glu Val Lys Asp Leu Ala Asp Lys Lys Glu Ser Val Ala His 
                805                 810                 815     


Trp Glu Ala Gln Ile Xaa Glu Ile Ile Gln Trp Val Ser Asp Glu Lys 
            820                 825                 830         


Asp Ala Arg Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Xaa Glu Glu 
        835                 840                 845             


Leu Glu Ala Leu Arg Asn Ser Ser Leu Gly Xaa Arg Ala Xaa Asp Met 
    850                 855                 860                 


Pro Trp Lys Met Arg Arg Phe Ala Lys Leu Asp Met Ser Ala Arg Leu 
865                 870                 875                 880 


Glu Leu Gln Ser Ala Leu Asp Ala Glu Ile Arg Ala Lys Gln Ala Ile 
                885                 890                 895     


Gln Glu Glu Leu Asn Lys Val Lys Ala Ser Asn Ile Ile Xaa Glu Cys 
            900                 905                 910         


Lys Leu Lys Asp Ser Glu Lys Lys Asn Leu Glu Leu Leu Ser Glu Ile 
        915                 920                 925             


Glu Gln Leu Ile Lys Asp Xaa Glu Glu Leu Arg Ser Glu Lys Gly Ile 
    930                 935                 940                 


Glu His Gln Asp Ser Gln His Ser Phe Leu Ala Phe Leu Asn Xaa Pro 
945                 950                 955                 960 


Xaa Asp Ala Leu Asp Gln Phe Glu Arg Ser Pro Ser Cys Xaa Pro Ala 
                965                 970                 975     


Ser Lys Gly Arg Arg Xaa Val Asp Ser Xaa Pro Leu Ser Val His Xaa 
            980                 985                 990         


Pro Xaa Leu Arg Lys Lys Gly Cys  Pro Gly Ser Xaa Gly  Phe Pro Pro 
        995                 1000                 1005             


Lys Arg  Lys Xaa His Gln Phe  Phe Val Lys Ser Phe  Xaa Xaa Pro 
    1010                 1015                 1020             


Xaa Lys  Cys His Gln Cys Xaa  Ser Leu Met Val Gly  Leu Ile Arg 
    1025                 1030                 1035             


Gln Gly  Cys Ser Cys Glu Val  Cys Gly Phe Ser Cys  His Ile Xaa 
    1040                 1045                 1050             


Cys Val  Asn Lys Ala Pro Xaa  Xaa Cys Pro Val Pro  Pro Glu Gln 
    1055                 1060                 1065             


Xaa Lys  Gly Pro Leu Gly Ile  Asp Pro Gln Lys Gly  Ile Gly Xaa 
    1070                 1075                 1080             


Ala Tyr  Glu Gly His Val Arg  Ile Pro Lys Pro Ala  Gly Val Lys 
    1085                 1090                 1095             


Lys Gly  Trp Gln Arg Ala Leu  Ala Ile Val Cys Asp  Phe Lys Leu 
    1100                 1105                 1110             


Phe Leu  Tyr Asp Ile Ala Glu  Gly Lys Ala Ser Gln  Pro Ser Val 
    1115                 1120                 1125             


Val Ile  Ser Gln Val Ile Asp  Met Arg Asp Glu Glu  Phe Ser Val 
    1130                 1135                 1140             


Ser Ser  Val Leu Ala Ser Asp  Val Ile His Ala Ser  Arg Lys Asp 
    1145                 1150                 1155             


Ile Pro  Cys Ile Phe Arg Val  Xaa Ala Ser Gln Leu  Ser Ala Ser 
    1160                 1165                 1170             


Asn Asn  Lys Cys Ser Ile Leu  Met Leu Ala Asp Xaa  Glu Asn Glu 
    1175                 1180                 1185             


Lys Asn  Lys Trp Val Gly Val  Leu Ser Glu Leu His  Lys Ile Leu 
    1190                 1195                 1200             


Lys Lys  Asn Lys Phe Arg Asp  Arg Ser Val Tyr Val  Pro Lys Glu 
    1205                 1210                 1215             


Ala Tyr  Asp Ser Xaa Leu Pro  Leu Ile Lys Xaa Xaa  Gln Ala Ala 
    1220                 1225                 1230             


Ala Ile  Ile Asp His Glu Arg  Ile Ala Leu Gly Asn  Glu Glu Gly 
    1235                 1240                 1245             


Leu Phe  Val Val His Val Xaa  Lys Asp Glu Ile Ile  Arg Val Gly 
    1250                 1255                 1260             


Asp Asn  Lys Lys Ile His Gln  Ile Glu Leu Ile Pro  Asn Asp Gln 
    1265                 1270                 1275             


Leu Val  Ala Val Ile Ser Gly  Arg Asn Arg His Val  Arg Leu Phe 
    1280                 1285                 1290             


Pro Met  Ser Ala Leu Asp Gly  Arg Glu Xaa Asp Phe  Tyr Lys Leu 
    1295                 1300                 1305             


Ser Glu  Xaa Lys Gly Cys Gln  Xaa Val Xaa Ser Gly  Lys Val Arg 
    1310                 1315                 1320             


His Gly  Ala Leu Xaa Cys Leu  Cys Val Ala Met Lys  Arg Gln Val 
    1325                 1330                 1335             


Leu Cys  Tyr Glu Leu Phe Gln  Ser Lys Xaa Arg His  Arg Lys Phe 
    1340                 1345                 1350             


Lys Glu  Ile Gln Val Pro Tyr  Asn Val Gln Trp Met  Ala Ile Phe 
    1355                 1360                 1365             


Ser Glu  Gln Leu Cys Val Gly  Phe Gln Ser Gly Phe  Leu Arg Tyr 
    1370                 1375                 1380             


Pro Leu  Asn Gly Glu Gly Asn  Pro Tyr Ser Met Leu  His Ser Asn 
    1385                 1390                 1395             


Asp His  Xaa Leu Ser Phe Ile  Ala His Gln Pro Met  Asp Ala Ile 
    1400                 1405                 1410             


Cys Ala  Val Glu Ile Ser Ser  Lys Glu Tyr Leu Leu  Cys Phe Asn 
    1415                 1420                 1425             


Ser Ile  Gly Ile Tyr Xaa Asp  Cys Gln Gly Arg Arg  Ser Arg Gln 
    1430                 1435                 1440             


Gln Glu  Leu Met Trp Pro Ala  Asn Pro Ser Ser Cys  Cys Tyr Asn 
    1445                 1450                 1455             


Ala Pro  Tyr Leu Ser Val Tyr  Ser Glu Asn Ala Val  Asp Ile Phe 
    1460                 1465                 1470             


Asp Val  Asn Ser Met Glu Trp  Ile Gln Xaa Leu Pro  Leu Lys Lys 
    1475                 1480                 1485             


Val Arg  Pro Leu Asn Asn Glu  Gly Ser Leu Asn Leu  Leu Gly Leu 
    1490                 1495                 1500             


Glu Xaa  Ile Arg Leu Ile Tyr  Phe Lys Asn Lys Met  Ala Glu Gly 
    1505                 1510                 1515             


Asp Glu  Leu Val Val Pro Glu  Xaa Ser Asp Asn Ser  Arg Lys Gln 
    1520                 1525                 1530             


Met Val  Arg Asn Ile Asn Asn  Lys Arg Arg Tyr Ser  Phe Arg Val 
    1535                 1540                 1545             


Pro Glu  Glu Glu Arg Met Gln  Gln Arg Arg Glu Met  Leu Arg Asp 
    1550                 1555                 1560             


Pro Glu  Met Arg Asn Lys Leu  Ile Ser Asn Pro Xaa  Asn Phe Asn 
    1565                 1570                 1575             


His Ile  Ala His Met Gly Pro  Gly Asp Gly Ile Gln  Ile Leu Lys 
    1580                 1585                 1590             


Asp Leu  Pro Met Asn Pro Arg  Pro Gln Glu Ser Arg  Xaa Val Phe 
    1595                 1600                 1605             


Ser Gly  Ser Val Ser Ile Pro  Ser Ile Xaa Lys Ser  Arg Pro Glu 
    1610                 1615                 1620             


Pro Gly  Arg Ser Met Ser Ala  Ser Ser Gly Leu Ser  Ala Arg Ser 
    1625                 1630                 1635             


Ser Ala  Gln Asn Gly Ser Ala  Leu Lys Arg Glu Phe  Ser Gly Gly 
    1640                 1645                 1650             


Ser Tyr  Ser Ala Lys Arg Gln  Pro Met Pro Ser Pro  Ser Glu Gly 
    1655                 1660                 1665             


Ser Leu  Ser Ser Gly Gly Met  Asp Gln Gly Ser Asp  Ala Pro Ala 
    1670                 1675                 1680             


Arg Asp  Phe Asp Gly Glu Asp  Ser Asp Ser Pro Arg  His Ser Xaa 
    1685                 1690                 1695             


Ala Ser  Asn Ser Ser Asn Leu  Ser Ser Pro Pro Ser  Pro Ala Ser 
    1700                 1705                 1710             


Pro Arg  Lys Xaa Lys Ser Leu  Ser Leu Glu Ser Xaa  Asp Arg Gly 
    1715                 1720                 1725             


Ser Trp  Asp Pro 
    1730         


<210> 5646
<211> 546
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<400> 5646
Xaa Asp Ile Ala Glu Gly Lys Ala Ser Gln Pro Ser Val Val Ile Ser 
1               5                   10                  15      


Gln Val Ile Asp Met Arg Asp Glu Glu Phe Ser Val Ser Ser Val Leu 
            20                  25                  30          


Ala Ser Asp Val Ile His Ala Ser Arg Lys Asp Ile Pro Cys Ile Phe 
        35                  40                  45              


Arg Val Xaa Ala Ser Gln Leu Ser Ala Ser Asn Asn Lys Cys Ser Ile 
    50                  55                  60                  


Leu Met Leu Ala Asp Xaa Glu Asn Glu Lys Asn Lys Trp Val Gly Val 
65                  70                  75                  80  


Leu Ser Glu Leu His Lys Ile Leu Lys Lys Asn Lys Phe Arg Asp Arg 
                85                  90                  95      


Ser Val Tyr Val Pro Lys Glu Ala Tyr Asp Ser Xaa Leu Pro Leu Ile 
            100                 105                 110         


Lys Xaa Xaa Gln Ala Ala Ala Ile Ile Asp His Glu Arg Ile Ala Leu 
        115                 120                 125             


Gly Asn Glu Glu Gly Leu Phe Val Val His Val Xaa Lys Asp Glu Ile 
    130                 135                 140                 


Ile Arg Val Gly Asp Asn Lys Lys Ile His Gln Ile Glu Leu Ile Pro 
145                 150                 155                 160 


Asn Asp Gln Leu Val Ala Val Ile Ser Gly Arg Asn Arg His Val Arg 
                165                 170                 175     


Leu Phe Pro Met Ser Ala Leu Asp Gly Arg Glu Xaa Asp Phe Tyr Lys 
            180                 185                 190         


Leu Ser Glu Xaa Lys Gly Cys Gln Xaa Val Xaa Ser Gly Lys Val Arg 
        195                 200                 205             


His Gly Ala Leu Xaa Cys Leu Cys Val Ala Met Lys Arg Gln Val Leu 
    210                 215                 220                 


Cys Tyr Glu Leu Phe Gln Ser Lys Xaa Arg His Arg Lys Phe Lys Glu 
225                 230                 235                 240 


Ile Gln Val Pro Tyr Asn Val Gln Trp Met Ala Ile Phe Ser Glu Gln 
                245                 250                 255     


Leu Cys Val Gly Phe Gln Ser Gly Phe Leu Arg Tyr Pro Leu Asn Gly 
            260                 265                 270         


Glu Gly Asn Pro Tyr Ser Met Leu His Ser Asn Asp His Xaa Leu Ser 
        275                 280                 285             


Phe Ile Ala His Gln Pro Met Asp Ala Ile Cys Ala Val Glu Ile Ser 
    290                 295                 300                 


Ser Lys Glu Tyr Leu Leu Cys Phe Asn Ser Ile Gly Ile Tyr Xaa Asp 
305                 310                 315                 320 


Cys Gln Gly Arg Arg Ser Arg Gln Gln Glu Leu Met Trp Pro Ala Asn 
                325                 330                 335     


Pro Ser Ser Cys Cys Tyr Asn Ala Pro Tyr Leu Ser Val Tyr Ser Glu 
            340                 345                 350         


Asn Ala Val Asp Ile Phe Asp Val Asn Ser Met Glu Trp Ile Gln Xaa 
        355                 360                 365             


Leu Pro Leu Lys Lys Val Arg Pro Leu Asn Asn Glu Gly Ser Leu Asn 
    370                 375                 380                 


Leu Leu Gly Leu Glu Xaa Ile Arg Leu Ile Tyr Phe Lys Asn Lys Met 
385                 390                 395                 400 


Ala Glu Gly Asp Glu Leu Val Val Pro Glu Xaa Ser Asp Asn Ser Arg 
                405                 410                 415     


Lys Gln Met Val Arg Asn Ile Asn Asn Lys Arg Arg Tyr Ser Phe Arg 
            420                 425                 430         


Val Pro Glu Glu Glu Arg Met Gln Gln Arg Arg Glu Met Leu Arg Asp 
        435                 440                 445             


Pro Glu Met Arg Asn Lys Leu Ile Ser Asn Pro Xaa Asn Phe Asn His 
    450                 455                 460                 


Ile Ala His Met Gly Pro Gly Asp Gly Ile Gln Ile Leu Lys Asp Leu 
465                 470                 475                 480 


Pro Met Asn Pro Arg Pro Gln Glu Ser Arg Xaa Val Phe Ser Gly Ser 
                485                 490                 495     


Val Ser Ile Pro Ser Ile Xaa Lys Ser Arg Pro Glu Pro Gly Arg Ser 
            500                 505                 510         


Met Ser Ala Ser Ser Gly Leu Ser Ala Ser Lys Cys Arg Gly Tyr Arg 
        515                 520                 525             


Lys Val Pro Leu Arg Gln Gly Asp Pro Gln Leu Pro Pro Leu Leu Ser 
    530                 535                 540                 


Arg Gly 
545     


<210> 5647
<211> 1048
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<400> 5647
Xaa Glu Gly Ile His Ala Asn Glu Ile Lys Asn Leu Lys Lys Glu Leu 
1               5                   10                  15      


His Asp Ser Glu Gly Gln Gln Leu Ala Leu Asn Lys Glu Ile Met Ile 
            20                  25                  30          


Leu Lys Asp Lys Leu Glu Lys Xaa Arg Arg Glu Ser Gln Ser Glu Arg 
        35                  40                  45              


Glu Glu Phe Glu Ser Glu Phe Lys Gln Gln Tyr Glu Arg Glu Lys Val 
    50                  55                  60                  


Leu Leu Xaa Glu Glu Asn Lys Lys Leu Xaa Ser Glu Leu Asp Lys Leu 
65                  70                  75                  80  


Xaa Xaa Leu Tyr Glu Asn Leu Ser Ile His Asn Gln Gln Leu Glu Glu 
                85                  90                  95      


Glu Val Lys Asp Leu Ala Asp Lys Lys Glu Ser Val Ala His Trp Glu 
            100                 105                 110         


Ala Gln Ile Xaa Glu Ile Ile Gln Trp Val Ser Asp Glu Lys Asp Ala 
        115                 120                 125             


Arg Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Xaa Glu Glu Leu Glu 
    130                 135                 140                 


Ala Leu Arg Asn Ser Ser Leu Gly Xaa Arg Ala Xaa Asp Met Pro Trp 
145                 150                 155                 160 


Lys Met Arg Arg Phe Ala Lys Leu Asp Met Ser Ala Arg Leu Glu Leu 
                165                 170                 175     


Gln Ser Ala Leu Asp Ala Glu Ile Arg Ala Lys Gln Ala Ile Gln Glu 
            180                 185                 190         


Glu Leu Asn Lys Val Lys Ala Ser Asn Ile Ile Xaa Glu Cys Lys Leu 
        195                 200                 205             


Lys Asp Ser Glu Lys Lys Asn Leu Glu Leu Leu Ser Glu Ile Glu Gln 
    210                 215                 220                 


Leu Ile Lys Asp Xaa Glu Glu Leu Arg Ser Glu Lys Gly Ile Glu His 
225                 230                 235                 240 


Gln Asp Ser Gln His Ser Phe Leu Ala Phe Leu Asn Xaa Pro Xaa Asp 
                245                 250                 255     


Ala Leu Asp Gln Phe Glu Xaa Asp Pro Val Glu Asn Xaa Tyr Val Trp 
            260                 265                 270         


Asn Pro Ser Val Lys Phe His Ile Gln Ser Arg Ser Xaa Ser Pro Ser 
        275                 280                 285             


Xaa Ser Ser Glu Ala Glu Pro Val Lys Xaa Val Asp Ser Xaa Pro Leu 
    290                 295                 300                 


Ser Val His Xaa Pro Xaa Leu Arg Lys Lys Gly Cys Pro Gly Ser Xaa 
305                 310                 315                 320 


Gly Phe Pro Pro Lys Arg Lys Xaa His Gln Phe Phe Val Lys Ser Phe 
                325                 330                 335     


Xaa Xaa Pro Xaa Lys Cys His Gln Cys Xaa Ser Leu Met Val Gly Leu 
            340                 345                 350         


Ile Arg Gln Gly Cys Ser Cys Glu Val Cys Gly Phe Ser Cys His Ile 
        355                 360                 365             


Xaa Cys Val Asn Lys Ala Pro Xaa Xaa Cys Pro Val Pro Pro Glu Gln 
    370                 375                 380                 


Xaa Lys Gly Pro Leu Gly Ile Asp Pro Gln Lys Gly Ile Gly Xaa Ala 
385                 390                 395                 400 


Tyr Glu Gly His Val Arg Ile Pro Lys Pro Ala Gly Val Lys Lys Gly 
                405                 410                 415     


Trp Gln Arg Ala Leu Ala Ile Val Cys Asp Phe Lys Leu Phe Leu Tyr 
            420                 425                 430         


Asp Ile Ala Glu Gly Lys Ala Ser Gln Pro Ser Val Val Ile Ser Gln 
        435                 440                 445             


Val Ile Asp Met Arg Asp Glu Glu Phe Ser Val Ser Ser Val Leu Ala 
    450                 455                 460                 


Ser Asp Val Ile His Ala Ser Arg Lys Asp Ile Pro Cys Ile Phe Arg 
465                 470                 475                 480 


Val Xaa Ala Ser Gln Leu Ser Ala Ser Asn Asn Lys Cys Ser Ile Leu 
                485                 490                 495     


Met Leu Ala Asp Xaa Glu Asn Glu Lys Asn Lys Trp Val Gly Val Leu 
            500                 505                 510         


Ser Glu Leu His Lys Ile Leu Lys Lys Asn Lys Phe Arg Asp Arg Ser 
        515                 520                 525             


Val Tyr Val Pro Lys Glu Ala Tyr Asp Ser Xaa Leu Pro Leu Ile Lys 
    530                 535                 540                 


Xaa Xaa Gln Ala Ala Ala Ile Ile Asp His Glu Arg Ile Ala Leu Gly 
545                 550                 555                 560 


Asn Glu Glu Gly Leu Phe Val Val His Val Xaa Lys Asp Glu Ile Ile 
                565                 570                 575     


Arg Val Gly Asp Asn Lys Lys Ile His Gln Ile Glu Leu Ile Pro Asn 
            580                 585                 590         


Asp Gln Leu Val Ala Val Ile Ser Gly Arg Asn Arg His Val Arg Leu 
        595                 600                 605             


Phe Pro Met Ser Ala Leu Asp Gly Arg Glu Xaa Asp Phe Tyr Lys Leu 
    610                 615                 620                 


Ser Glu Xaa Lys Gly Cys Gln Xaa Val Xaa Ser Gly Lys Val Arg His 
625                 630                 635                 640 


Gly Ala Leu Xaa Cys Leu Cys Val Ala Met Lys Arg Gln Val Leu Cys 
                645                 650                 655     


Tyr Glu Leu Phe Gln Ser Lys Xaa Arg His Arg Lys Phe Lys Glu Ile 
            660                 665                 670         


Gln Val Pro Tyr Asn Val Gln Trp Met Ala Ile Phe Ser Glu Gln Leu 
        675                 680                 685             


Cys Val Gly Phe Gln Ser Gly Phe Leu Arg Tyr Pro Leu Asn Gly Glu 
    690                 695                 700                 


Gly Asn Pro Tyr Ser Met Leu His Ser Asn Asp His Xaa Leu Ser Phe 
705                 710                 715                 720 


Ile Ala His Gln Pro Met Asp Ala Ile Cys Ala Val Glu Ile Ser Ser 
                725                 730                 735     


Lys Glu Tyr Leu Leu Cys Phe Asn Ser Ile Gly Ile Tyr Xaa Asp Cys 
            740                 745                 750         


Gln Gly Arg Arg Ser Arg Gln Gln Glu Leu Met Trp Pro Ala Asn Pro 
        755                 760                 765             


Ser Ser Cys Cys Tyr Asn Ala Pro Tyr Leu Ser Val Tyr Ser Glu Asn 
    770                 775                 780                 


Ala Val Asp Ile Phe Asp Val Asn Ser Met Glu Trp Ile Gln Xaa Leu 
785                 790                 795                 800 


Pro Leu Lys Lys Val Arg Pro Leu Asn Asn Glu Gly Ser Leu Asn Leu 
                805                 810                 815     


Leu Gly Leu Glu Xaa Ile Arg Leu Ile Tyr Phe Lys Asn Lys Met Ala 
            820                 825                 830         


Glu Gly Asp Glu Leu Val Val Pro Glu Xaa Ser Asp Asn Ser Arg Lys 
        835                 840                 845             


Gln Met Val Arg Asn Ile Asn Asn Lys Arg Arg Tyr Ser Phe Arg Val 
    850                 855                 860                 


Pro Glu Glu Glu Arg Met Gln Gln Arg Arg Glu Met Leu Arg Asp Pro 
865                 870                 875                 880 


Glu Met Arg Asn Lys Leu Ile Ser Asn Pro Xaa Asn Phe Asn His Ile 
                885                 890                 895     


Ala His Met Gly Pro Gly Asp Gly Ile Gln Ile Leu Lys Asp Leu Pro 
            900                 905                 910         


Met Asn Pro Arg Pro Gln Glu Ser Arg Xaa Val Phe Ser Gly Ser Val 
        915                 920                 925             


Ser Ile Pro Ser Ile Xaa Lys Ser Arg Pro Glu Pro Gly Arg Ser Met 
    930                 935                 940                 


Ser Ala Ser Ser Gly Leu Ser Ala Arg Ser Ser Ala Gln Asn Gly Ser 
945                 950                 955                 960 


Ala Leu Lys Arg Glu Phe Ser Gly Gly Ser Tyr Ser Ala Lys Arg Gln 
                965                 970                 975     


Pro Met Pro Ser Pro Ser Glu Gly Ser Leu Ser Ser Gly Gly Met Asp 
            980                 985                 990         


Gln Gly Ser Asp Ala Pro Ala Arg  Asp Phe Asp Gly Glu  Asp Ser Asp 
        995                 1000                 1005             


Ser Pro  Arg His Ser Xaa Ala  Ser Asn Ser Ser Asn  Leu Ser Ser 
    1010                 1015                 1020             


Pro Pro  Ser Pro Ala Ser Pro  Arg Lys Xaa Lys Ser  Leu Ser Leu 
    1025                 1030                 1035             


Glu Ser  Xaa Asp Arg Gly Ser  Trp Asp Pro 
    1040                 1045             


<210> 5648
<211> 984
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<400> 5648
Xaa Gln Leu Glu Glu Glu Val Lys Asp Leu Ala Asp Lys Lys Glu Ser 
1               5                   10                  15      


Val Ala His Trp Glu Ala Gln Ile Xaa Glu Ile Ile Gln Trp Val Ser 
            20                  25                  30          


Asp Glu Lys Asp Ala Arg Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met 
        35                  40                  45              


Xaa Glu Glu Leu Glu Ala Leu Arg Asn Ser Ser Leu Gly Xaa Arg Ala 
    50                  55                  60                  


Xaa Asp Met Pro Trp Lys Met Arg Arg Phe Ala Lys Leu Asp Met Ser 
65                  70                  75                  80  


Ala Arg Leu Glu Leu Gln Ser Ala Leu Asp Ala Glu Ile Arg Ala Lys 
                85                  90                  95      


Gln Ala Ile Gln Glu Glu Leu Asn Lys Val Lys Ala Ser Asn Ile Ile 
            100                 105                 110         


Xaa Glu Cys Lys Leu Lys Asp Ser Glu Lys Lys Asn Leu Glu Leu Leu 
        115                 120                 125             


Ser Glu Ile Glu Gln Leu Ile Lys Asp Xaa Glu Glu Leu Arg Ser Glu 
    130                 135                 140                 


Lys Gly Ile Glu His Gln Asp Ser Gln His Ser Phe Leu Ala Phe Leu 
145                 150                 155                 160 


Asn Xaa Pro Xaa Asp Ala Leu Asp Gln Phe Glu Xaa Val Asp Ser Xaa 
                165                 170                 175     


Pro Leu Ser Val His Xaa Pro Xaa Leu Arg Lys Lys Gly Cys Pro Gly 
            180                 185                 190         


Ser Xaa Gly Phe Pro Pro Lys Arg Lys Xaa His Gln Phe Phe Val Lys 
        195                 200                 205             


Ser Phe Xaa Xaa Pro Xaa Lys Cys His Gln Cys Xaa Ser Leu Met Val 
    210                 215                 220                 


Gly Leu Ile Arg Gln Gly Cys Ser Cys Glu Val Cys Gly Phe Ser Cys 
225                 230                 235                 240 


His Ile Xaa Cys Val Asn Lys Ala Pro Xaa Xaa Cys Pro Val Pro Pro 
                245                 250                 255     


Glu Gln Xaa Lys Gly Pro Leu Gly Ile Asp Pro Gln Lys Gly Ile Gly 
            260                 265                 270         


Xaa Ala Tyr Glu Gly His Val Arg Ile Pro Lys Pro Ala Gly Val Lys 
        275                 280                 285             


Lys Gly Trp Gln Arg Ala Leu Ala Ile Val Cys Asp Phe Lys Leu Phe 
    290                 295                 300                 


Leu Tyr Asp Ile Ala Glu Gly Lys Ala Ser Gln Pro Ser Val Val Ile 
305                 310                 315                 320 


Ser Gln Val Ile Asp Met Arg Asp Glu Glu Phe Ser Val Ser Ser Val 
                325                 330                 335     


Leu Ala Ser Asp Val Ile His Ala Ser Arg Lys Asp Ile Pro Cys Ile 
            340                 345                 350         


Phe Arg Val Xaa Ala Ser Gln Leu Ser Ala Ser Asn Asn Lys Cys Ser 
        355                 360                 365             


Ile Leu Met Leu Ala Asp Xaa Glu Asn Glu Lys Asn Lys Trp Val Gly 
    370                 375                 380                 


Val Leu Ser Glu Leu His Lys Ile Leu Lys Lys Asn Lys Phe Arg Asp 
385                 390                 395                 400 


Arg Ser Val Tyr Val Pro Lys Glu Ala Tyr Asp Ser Xaa Leu Pro Leu 
                405                 410                 415     


Ile Lys Xaa Xaa Gln Ala Ala Ala Ile Ile Asp His Glu Arg Ile Ala 
            420                 425                 430         


Leu Gly Asn Glu Glu Gly Leu Phe Val Val His Val Xaa Lys Asp Glu 
        435                 440                 445             


Ile Ile Arg Val Gly Asp Asn Lys Lys Ile His Gln Ile Glu Leu Ile 
    450                 455                 460                 


Pro Asn Asp Gln Leu Val Ala Val Ile Ser Gly Arg Asn Arg His Val 
465                 470                 475                 480 


Arg Leu Phe Pro Met Ser Ala Leu Asp Gly Arg Glu Xaa Asp Phe Tyr 
                485                 490                 495     


Lys Leu Ser Glu Xaa Lys Gly Cys Gln Xaa Val Xaa Ser Gly Lys Val 
            500                 505                 510         


Arg His Gly Ala Leu Xaa Cys Leu Cys Val Ala Met Lys Arg Gln Val 
        515                 520                 525             


Leu Cys Tyr Glu Leu Phe Gln Ser Lys Xaa Arg His Arg Lys Phe Lys 
    530                 535                 540                 


Glu Ile Gln Val Pro Tyr Asn Val Gln Trp Met Ala Ile Phe Ser Glu 
545                 550                 555                 560 


Gln Leu Cys Val Gly Phe Gln Ser Gly Phe Leu Arg Tyr Pro Leu Asn 
                565                 570                 575     


Gly Glu Gly Asn Pro Tyr Ser Met Leu His Ser Asn Asp His Xaa Leu 
            580                 585                 590         


Ser Phe Ile Ala His Gln Pro Met Asp Ala Ile Cys Ala Val Glu Ile 
        595                 600                 605             


Ser Ser Lys Glu Tyr Leu Leu Cys Phe Asn Ser Ile Gly Ile Tyr Xaa 
    610                 615                 620                 


Asp Cys Gln Gly Arg Arg Ser Arg Gln Gln Glu Leu Met Trp Pro Ala 
625                 630                 635                 640 


Asn Pro Ser Ser Cys Cys Tyr Asn Ala Pro Tyr Leu Ser Val Tyr Ser 
                645                 650                 655     


Glu Asn Ala Val Asp Ile Phe Asp Val Asn Ser Met Glu Trp Ile Gln 
            660                 665                 670         


Xaa Leu Pro Leu Lys Lys Val Arg Pro Leu Asn Asn Glu Gly Ser Leu 
        675                 680                 685             


Asn Leu Leu Gly Leu Glu Xaa Ile Arg Leu Ile Tyr Phe Lys Asn Lys 
    690                 695                 700                 


Met Ala Glu Gly Asp Glu Leu Val Val Pro Glu Xaa Ser Asp Asn Ser 
705                 710                 715                 720 


Arg Lys Gln Met Val Arg Asn Ile Asn Asn Lys Arg Arg Tyr Ser Phe 
                725                 730                 735     


Arg Val Pro Glu Glu Glu Arg Met Gln Gln Arg Arg Glu Met Leu Arg 
            740                 745                 750         


Asp Pro Glu Met Arg Asn Lys Leu Ile Ser Asn Pro Xaa Asn Phe Asn 
        755                 760                 765             


His Ile Ala His Met Gly Pro Gly Asp Gly Ile Gln Ile Leu Lys Asp 
    770                 775                 780                 


Leu Pro Met Pro Gly Phe Pro Tyr Pro Ser Pro His His His Ser Gly 
785                 790                 795                 800 


Leu Ile Ser Ser Pro Ile Asn Phe Glu His Ile Tyr His Met Xaa Val 
                805                 810                 815     


Asn Ser Ala Glu Lys Phe Leu Ser Pro Asp Ser Ile Asn Pro Glu Tyr 
            820                 825                 830         


Ser Pro Ser Leu Arg Ser Val Pro Gly Xaa Pro Ser Phe Met Xaa Leu 
        835                 840                 845             


Arg Asn Pro Arg Pro Gln Glu Ser Arg Xaa Val Phe Ser Gly Ser Val 
    850                 855                 860                 


Ser Ile Pro Ser Ile Xaa Lys Ser Arg Pro Glu Pro Gly Arg Ser Met 
865                 870                 875                 880 


Ser Ala Ser Ser Gly Leu Ser Ala Arg Ser Ser Ala Gln Asn Gly Ser 
                885                 890                 895     


Ala Leu Lys Arg Glu Phe Ser Gly Gly Ser Tyr Ser Ala Lys Arg Gln 
            900                 905                 910         


Pro Met Pro Ser Pro Ser Glu Gly Ser Leu Ser Ser Gly Gly Met Asp 
        915                 920                 925             


Gln Gly Ser Asp Ala Pro Ala Arg Asp Phe Asp Gly Glu Asp Ser Asp 
    930                 935                 940                 


Ser Pro Arg His Ser Xaa Ala Ser Asn Ser Ser Asn Leu Ser Ser Pro 
945                 950                 955                 960 


Pro Ser Pro Ala Ser Pro Arg Lys Xaa Lys Ser Leu Ser Leu Glu Ser 
                965                 970                 975     


Xaa Asp Arg Gly Ser Trp Asp Pro 
            980                 


<210> 5649
<211> 728
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<400> 5649
Xaa Val Ser Asp Glu Lys Asp Ala Arg Gly Tyr Leu Gln Ala Leu Ala 
1               5                   10                  15      


Ser Lys Met Xaa Glu Glu Leu Glu Ala Leu Arg Asn Ser Ser Leu Gly 
            20                  25                  30          


Xaa Arg Ala Xaa Asp Met Pro Trp Lys Met Arg Arg Phe Ala Lys Leu 
        35                  40                  45              


Asp Met Ser Ala Arg Leu Glu Leu Gln Ser Ala Leu Asp Ala Glu Ile 
    50                  55                  60                  


Arg Ala Lys Gln Ala Ile Gln Glu Glu Leu Asn Lys Val Lys Ala Ser 
65                  70                  75                  80  


Asn Ile Ile Xaa Glu Cys Lys Leu Lys Asp Ser Glu Lys Lys Asn Leu 
                85                  90                  95      


Glu Leu Leu Ser Glu Ile Glu Gln Leu Ile Lys Asp Xaa Glu Glu Leu 
            100                 105                 110         


Arg Ser Glu Lys Gly Ile Glu His Gln Asp Ser Gln His Ser Phe Leu 
        115                 120                 125             


Ala Phe Leu Asn Xaa Pro Xaa Asp Ala Leu Asp Gln Phe Glu Asp Ser 
    130                 135                 140                 


Phe Ser Ser Ser Ser Ser Ser Leu Ile Asp Phe Leu Asp Asp Xaa Asp 
145                 150                 155                 160 


Pro Val Glu Asn Xaa Tyr Val Trp Asn Pro Ser Val Lys Phe His Ile 
                165                 170                 175     


Gln Ser Arg Ser Xaa Ser Pro Ser Xaa Ser Ser Glu Ala Glu Pro Val 
            180                 185                 190         


Lys Xaa Val Asp Ser Xaa Pro Leu Ser Val His Xaa Pro Xaa Leu Arg 
        195                 200                 205             


Lys Lys Gly Cys Pro Gly Ser Xaa Gly Phe Pro Pro Lys Arg Lys Xaa 
    210                 215                 220                 


His Gln Phe Phe Val Lys Ser Phe Xaa Xaa Pro Xaa Lys Cys His Gln 
225                 230                 235                 240 


Cys Xaa Ser Leu Met Val Gly Leu Ile Arg Gln Gly Cys Ser Cys Glu 
                245                 250                 255     


Val Cys Gly Phe Ser Cys His Ile Xaa Cys Val Asn Lys Ala Pro Xaa 
            260                 265                 270         


Xaa Cys Pro Val Pro Pro Glu Gln Xaa Lys Gly Pro Leu Gly Ile Asp 
        275                 280                 285             


Pro Gln Lys Gly Ile Gly Xaa Ala Tyr Glu Gly His Val Arg Ile Pro 
    290                 295                 300                 


Lys Pro Ala Gly Val Lys Lys Gly Trp Gln Arg Ala Leu Ala Ile Val 
305                 310                 315                 320 


Cys Asp Phe Lys Leu Phe Leu Tyr Asp Ile Ala Glu Gly Lys Ala Ser 
                325                 330                 335     


Gln Pro Ser Val Val Ile Ser Gln Val Ile Asp Met Arg Asp Glu Glu 
            340                 345                 350         


Phe Ser Val Ser Ser Val Leu Ala Ser Asp Val Ile His Ala Ser Arg 
        355                 360                 365             


Lys Asp Ile Pro Cys Ile Phe Arg Val Xaa Ala Ser Gln Leu Ser Ala 
    370                 375                 380                 


Ser Asn Asn Lys Cys Ser Ile Leu Met Leu Ala Asp Xaa Glu Asn Glu 
385                 390                 395                 400 


Lys Asn Lys Trp Val Gly Val Leu Ser Glu Leu His Lys Ile Leu Lys 
                405                 410                 415     


Lys Asn Lys Phe Arg Asp Arg Ser Val Tyr Val Pro Lys Glu Ala Tyr 
            420                 425                 430         


Asp Ser Xaa Leu Pro Leu Ile Lys Xaa Xaa Gln Ala Ala Ala Ile Ile 
        435                 440                 445             


Asp His Glu Arg Ile Ala Leu Gly Asn Glu Glu Gly Leu Phe Val Val 
    450                 455                 460                 


His Val Xaa Lys Asp Glu Ile Ile Arg Val Gly Asp Asn Lys Lys Ile 
465                 470                 475                 480 


His Gln Ile Glu Leu Ile Pro Asn Asp Gln Leu Val Ala Val Ile Ser 
                485                 490                 495     


Gly Arg Asn Arg His Val Arg Leu Phe Pro Met Ser Ala Leu Asp Gly 
            500                 505                 510         


Arg Glu Xaa Asp Phe Tyr Lys Leu Ser Glu Xaa Lys Gly Cys Gln Xaa 
        515                 520                 525             


Val Xaa Ser Gly Lys Val Arg His Gly Ala Leu Xaa Cys Leu Cys Val 
    530                 535                 540                 


Ala Met Lys Arg Gln Val Leu Cys Tyr Glu Leu Phe Gln Ser Lys Xaa 
545                 550                 555                 560 


Arg His Arg Lys Phe Lys Glu Ile Gln Val Pro Tyr Asn Val Gln Trp 
                565                 570                 575     


Met Ala Ile Phe Ser Glu Gln Leu Cys Val Gly Phe Gln Ser Gly Phe 
            580                 585                 590         


Leu Arg Tyr Pro Leu Asn Gly Glu Gly Asn Pro Tyr Ser Met Leu His 
        595                 600                 605             


Ser Asn Asp His Xaa Leu Ser Phe Ile Ala His Gln Pro Met Asp Ala 
    610                 615                 620                 


Ile Cys Ala Val Glu Ile Ser Ser Lys Glu Tyr Leu Leu Cys Phe Asn 
625                 630                 635                 640 


Ser Ile Gly Ile Tyr Xaa Asp Cys Gln Gly Arg Arg Ser Arg Gln Gln 
                645                 650                 655     


Glu Leu Met Trp Pro Ala Asn Pro Ser Ser Cys Cys Tyr Asn Ala Pro 
            660                 665                 670         


Tyr Leu Ser Val Tyr Ser Glu Asn Ala Val Asp Ile Phe Asp Val Asn 
        675                 680                 685             


Ser Met Glu Trp Ile Gln Xaa Leu Pro Leu Lys Lys Val Arg Pro Leu 
    690                 695                 700                 


Asn Asn Glu Gly Ser Leu Asn Leu Leu Gly Leu Glu Xaa Ile Arg Leu 
705                 710                 715                 720 


Ile Tyr Phe Lys Asn Lys Met Ala 
                725             


<210> 5650
<211> 1711
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1012)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1108)..(1108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1179)..(1179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1189)..(1189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1245)..(1245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1268)..(1268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1325)..(1325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1342)..(1342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1360)..(1360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1474)..(1474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1477)..(1477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1491)..(1491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1497)..(1497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1511)..(1511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1539)..(1539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1550)..(1550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1587)..(1587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1625)..(1625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1652)..(1652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1674)..(1674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1678)..(1678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1711)..(1711)
<223> Selenocysteine

<400> 5650
Met Ser Ala Lys Val Arg Leu Lys Lys Leu Glu Gln Leu Leu Leu Asp 
1               5                   10                  15      


Gly Pro Trp Arg Asn Glu Ser Ala Leu Ser Val Glu Xaa Leu Leu Asp 
            20                  25                  30          


Val Leu Val Cys Leu Tyr Xaa Glu Cys Ser His Ser Ala Leu Arg Arg 
        35                  40                  45              


Asp Lys Tyr Val Ala Glu Phe Leu Glu Trp Ala Lys Pro Phe Xaa Gln 
    50                  55                  60                  


Leu Val Lys Glu Met Gln Leu His Arg Glu Asp Phe Glu Ile Ile Lys 
65                  70                  75                  80  


Val Ile Gly Arg Gly Ala Phe Gly Glu Val Ala Val Val Lys Met Lys 
                85                  90                  95      


Asn Xaa Glu Arg Ile Tyr Ala Met Lys Ile Leu Asn Lys Trp Glu Met 
            100                 105                 110         


Leu Lys Arg Ala Glu Xaa Ala Cys Phe Arg Glu Glu Arg Asp Val Leu 
        115                 120                 125             


Val Asn Gly Asp Cys Gln Trp Ile Xaa Ala Leu His Tyr Ala Phe Gln 
    130                 135                 140                 


Asp Glu Asn His Leu Tyr Leu Val Met Asp Tyr Tyr Val Gly Gly Asp 
145                 150                 155                 160 


Leu Leu Xaa Leu Leu Ser Lys Phe Glu Asp Lys Leu Pro Glu Asp Met 
                165                 170                 175     


Ala Arg Phe Tyr Ile Gly Glu Met Val Leu Ala Ile Asp Ser Ile His 
            180                 185                 190         


Gln Leu His Tyr Val His Arg Asp Ile Lys Pro Asp Asn Val Leu Leu 
        195                 200                 205             


Asp Val Asn Gly His Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu Lys 
    210                 215                 220                 


Met Asn Asp Asp Gly Xaa Val Gln Ser Ser Val Ala Val Gly Xaa Pro 
225                 230                 235                 240 


Asp Tyr Ile Ser Pro Glu Ile Leu Gln Ala Met Glu Asp Gly Met Gly 
                245                 250                 255     


Lys Tyr Gly Pro Glu Cys Asp Trp Trp Ser Leu Gly Val Cys Met Tyr 
            260                 265                 270         


Glu Met Leu Tyr Gly Glu Xaa Pro Phe Tyr Ala Glu Ser Leu Val Glu 
        275                 280                 285             


Xaa Tyr Gly Lys Ile Met Asn His Glu Glu Arg Phe Gln Phe Pro Ser 
    290                 295                 300                 


His Val Xaa Asp Val Ser Glu Glu Ala Lys Asp Leu Ile Gln Arg Leu 
305                 310                 315                 320 


Ile Cys Ser Arg Glu Arg Arg Leu Gly Gln Asn Gly Ile Glu Asp Phe 
                325                 330                 335     


Lys Lys His Ala Phe Phe Glu Gly Leu Asn Trp Glu Asn Ile Arg Asn 
            340                 345                 350         


Leu Glu Ala Pro Tyr Ile Pro Asp Val Ser Ser Pro Ser Asp Xaa Ser 
        355                 360                 365             


Asn Phe Asp Val Asp Asp Asp Val Leu Arg Asn Xaa Glu Ile Leu Pro 
    370                 375                 380                 


Pro Gly Ser His Xaa Gly Phe Ser Gly Leu His Leu Pro Phe Ile Gly 
385                 390                 395                 400 


Phe Xaa Phe Xaa Xaa Glu Ser Cys Phe Ser Asp Arg Gly Ser Leu Lys 
                405                 410                 415     


Ser Ile Met Gln Ser Asn Xaa Leu Xaa Lys Asp Glu Asp Val Gln Arg 
            420                 425                 430         


Asp Leu Glu His Ser Leu Gln Met Glu Ala Tyr Glu Arg Arg Ile Arg 
        435                 440                 445             


Arg Leu Glu Gln Glu Lys Leu Glu Leu Ser Arg Lys Leu Gln Glu Ser 
    450                 455                 460                 


Xaa Gln Xaa Val Gln Ser Leu His Gly Ser Ser Arg Ala Leu Ser Asn 
465                 470                 475                 480 


Ser Asn Arg Asp Lys Glu Ile Lys Lys Leu Asn Glu Glu Ile Glu Arg 
                485                 490                 495     


Leu Lys Asn Lys Ile Ala Asp Ser Asn Arg Leu Glu Arg Gln Leu Glu 
            500                 505                 510         


Asp Xaa Val Ala Leu Arg Gln Glu Arg Glu Asp Ser Xaa Gln Arg Leu 
        515                 520                 525             


Arg Gly Leu Glu Lys Gln His Arg Val Val Arg Gln Glu Lys Glu Glu 
    530                 535                 540                 


Leu His Lys Gln Leu Val Glu Ala Ser Glu Arg Leu Lys Ser Gln Ala 
545                 550                 555                 560 


Lys Glu Leu Lys Asp Ala His Gln Gln Arg Lys Leu Ala Leu Gln Glu 
                565                 570                 575     


Phe Ser Glu Leu Asn Glu Arg Met Ala Glu Leu Arg Ala Gln Lys Gln 
            580                 585                 590         


Lys Val Ser Arg Gln Leu Arg Asp Lys Glu Glu Glu Met Glu Val Ala 
        595                 600                 605             


Xaa Gln Lys Val Asp Ala Met Arg Gln Glu Met Arg Arg Ala Glu Lys 
    610                 615                 620                 


Leu Arg Lys Glu Leu Glu Ala Gln Leu Asp Asp Ala Val Ala Glu Ala 
625                 630                 635                 640 


Ser Lys Glu Arg Lys Leu Arg Glu His Ser Glu Asn Phe Cys Lys Gln 
                645                 650                 655     


Met Glu Ser Glu Leu Glu Ala Leu Lys Val Lys Gln Gly Gly Arg Gly 
            660                 665                 670         


Ala Gly Ala Xaa Leu Glu His Gln Gln Glu Ile Ser Lys Ile Lys Ser 
        675                 680                 685             


Glu Leu Glu Lys Lys Val Leu Phe Tyr Glu Glu Glu Leu Val Arg Arg 
    690                 695                 700                 


Glu Ala Ser His Val Leu Glu Val Lys Asn Val Lys Lys Glu Val His 
705                 710                 715                 720 


Asp Ser Glu Ser His Gln Leu Ala Leu Gln Lys Glu Ile Leu Met Leu 
                725                 730                 735     


Lys Asp Lys Leu Glu Lys Ser Lys Arg Glu Arg His Asn Glu Met Glu 
            740                 745                 750         


Glu Ala Val Gly Xaa Ile Lys Asp Lys Tyr Glu Arg Glu Arg Ala Met 
        755                 760                 765             


Leu Phe Asp Glu Asn Lys Lys Leu Xaa Ala Glu Asn Glu Lys Leu Cys 
    770                 775                 780                 


Ser Phe Val Asp Lys Leu Xaa Ala Gln Asn Arg Gln Leu Glu Asp Glu 
785                 790                 795                 800 


Leu Gln Asp Leu Ala Ala Lys Lys Glu Ser Val Ala His Trp Glu Ala 
                805                 810                 815     


Gln Ile Ala Glu Ile Ile Gln Trp Val Ser Asp Glu Lys Asp Ala Arg 
            820                 825                 830         


Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Xaa Glu Glu Leu Glu Ala 
        835                 840                 845             


Leu Arg Ser Ser Ser Leu Gly Ser Arg Xaa Leu Asp Pro Leu Trp Lys 
    850                 855                 860                 


Val Arg Arg Ser Gln Lys Leu Asp Met Ser Ala Arg Leu Glu Leu Gln 
865                 870                 875                 880 


Ser Ala Leu Glu Ala Glu Ile Arg Ala Lys Gln Leu Val Gln Glu Glu 
                885                 890                 895     


Leu Arg Lys Val Lys Asp Ala Asn Leu Xaa Leu Glu Ser Lys Leu Lys 
            900                 905                 910         


Asp Ser Glu Ala Lys Asn Arg Glu Leu Leu Glu Glu Met Glu Ile Leu 
        915                 920                 925             


Lys Lys Lys Met Glu Glu Lys Phe Arg Ala Asp Xaa Gly Leu Lys Leu 
    930                 935                 940                 


Pro Asp Phe Gln Asp Ser Ile Phe Glu Tyr Phe Asn Xaa Ala Pro Leu 
945                 950                 955                 960 


Ala His Asp Leu Xaa Phe Arg Xaa Ser Ser Ala Ser Glu Gln Glu Xaa 
                965                 970                 975     


Gln Ala Pro Lys Pro Glu Ala Ser Pro Ser Met Ser Val Ala Ala Ser 
            980                 985                 990         


Glu Gln Gln Glu Asp Met Ala Arg  Pro Pro Gln Arg Pro  Ser Ala Val 
        995                 1000                 1005             


Pro Leu  Pro Xaa Xaa Gln Ala  Leu Ala Leu Ala Gly  Pro Lys Pro 
    1010                 1015                 1020             


Lys Ala  His Gln Phe Ser Ile  Lys Ser Phe Ser Ser  Pro Xaa Gln 
    1025                 1030                 1035             


Cys Ser  His Cys Xaa Ser Leu  Met Val Gly Leu Ile  Arg Gln Gly 
    1040                 1045                 1050             


Tyr Ala  Cys Glu Val Cys Ser  Phe Ala Cys His Val  Ser Cys Lys 
    1055                 1060                 1065             


Asp Gly  Ala Pro Gln Val Cys  Pro Ile Pro Pro Glu  Gln Ser Lys 
    1070                 1075                 1080             


Arg Pro  Leu Gly Val Asp Val  Gln Arg Gly Ile Gly  Xaa Ala Tyr 
    1085                 1090                 1095             


Lys Gly  His Val Lys Val Pro  Lys Pro Xaa Gly Val  Lys Lys Gly 
    1100                 1105                 1110             


Trp Gln  Arg Ala Tyr Ala Val  Val Cys Asp Cys Lys  Leu Phe Leu 
    1115                 1120                 1125             


Tyr Asp  Leu Pro Glu Gly Lys  Ser Xaa Gln Pro Gly  Val Ile Ala 
    1130                 1135                 1140             


Ser Gln  Val Leu Asp Leu Arg  Asp Asp Glu Phe Ser  Val Ser Ser 
    1145                 1150                 1155             


Val Leu  Ala Ser Asp Val Ile  His Ala Xaa Arg Arg  Asp Ile Pro 
    1160                 1165                 1170             


Cys Ile  Phe Arg Val Xaa Ala  Ser Leu Leu Gly Ala  Pro Ser Lys 
    1175                 1180                 1185             


Xaa Ser  Ser Leu Leu Ile Leu  Xaa Glu Asn Glu Asn  Glu Lys Arg 
    1190                 1195                 1200             


Lys Trp  Val Gly Ile Leu Glu  Gly Leu Gln Ser Ile  Leu His Lys 
    1205                 1210                 1215             


Asn Arg  Leu Arg Asn Gln Val  Val His Val Pro Leu  Glu Ala Tyr 
    1220                 1225                 1230             


Asp Ser  Ser Leu Pro Leu Ile  Lys Ala Ile Leu Xaa  Ala Ala Ile 
    1235                 1240                 1245             


Val Asp  Ala Asp Arg Ile Ala  Val Gly Leu Glu Glu  Gly Leu Tyr 
    1250                 1255                 1260             


Val Ile  Glu Val Xaa Arg Asp  Val Ile Val Arg Ala  Ala Asp Cys 
    1265                 1270                 1275             


Lys Lys  Val His Gln Ile Glu  Leu Ala Pro Arg Glu  Lys Ile Val 
    1280                 1285                 1290             


Ile Leu  Leu Cys Gly Arg Asn  His His Val His Leu  Tyr Pro Trp 
    1295                 1300                 1305             


Ser Ser  Leu Asp Gly Ala Glu  Gly Ser Phe Asp Ile  Lys Leu Pro 
    1310                 1315                 1320             


Glu Xaa  Lys Gly Cys Gln Leu  Met Ala Xaa Ala Xaa  Leu Lys Arg 
    1325                 1330                 1335             


Asn Ser  Gly Xaa Cys Leu Phe  Val Ala Val Lys Arg  Leu Ile Leu 
    1340                 1345                 1350             


Cys Tyr  Glu Ile Gln Arg Xaa  Lys Pro Phe His Arg  Lys Phe Asn 
    1355                 1360                 1365             


Glu Ile  Val Ala Pro Gly Ser  Val Gln Cys Leu Ala  Val Leu Arg 
    1370                 1375                 1380             


Asp Arg  Leu Cys Val Gly Tyr  Pro Ser Gly Phe Cys  Leu Leu Ser 
    1385                 1390                 1395             


Ile Gln  Gly Asp Gly Gln Pro  Leu Asn Leu Val Asn  Pro Asn Asp 
    1400                 1405                 1410             


Pro Ser  Leu Ala Phe Leu Ser  Gln Gln Ser Phe Asp  Ala Leu Cys 
    1415                 1420                 1425             


Ala Val  Glu Leu Glu Ser Glu  Glu Tyr Leu Leu Cys  Phe Ser His 
    1430                 1435                 1440             


Met Gly  Leu Tyr Val Asp Pro  Gln Gly Arg Arg Ala  Arg Ala Gln 
    1445                 1450                 1455             


Glu Leu  Met Trp Pro Ala Ala  Pro Val Ala Cys Ser  Cys Ser Pro 
    1460                 1465                 1470             


Xaa His  Val Xaa Val Tyr Ser  Glu Tyr Gly Val Asp  Val Phe Asp 
    1475                 1480                 1485             


Val Arg  Xaa Met Glu Trp Val  Gln Xaa Ile Gly Leu  Arg Arg Ile 
    1490                 1495                 1500             


Arg Pro  Leu Asn Ser Glu Gly  Xaa Leu Asn Leu Leu  Asn Cys Glu 
    1505                 1510                 1515             


Pro Pro  Arg Leu Ile Tyr Phe  Lys Ser Lys Phe Ser  Gly Ala Val 
    1520                 1525                 1530             


Leu Asn  Val Pro Asp Xaa Ser  Asp Asn Ser Lys Lys  Gln Met Leu 
    1535                 1540                 1545             


Arg Xaa  Arg Ser Lys Arg Arg  Phe Val Phe Lys Val  Pro Glu Glu 
    1550                 1555                 1560             


Glu Arg  Leu Gln Gln Arg Arg  Glu Met Leu Arg Asp  Pro Glu Leu 
    1565                 1570                 1575             


Arg Ser  Lys Met Ile Ser Asn  Pro Xaa Asn Phe Asn  His Val Ala 
    1580                 1585                 1590             


His Met  Gly Pro Gly Asp Gly  Met Gln Val Leu Met  Asp Leu Pro 
    1595                 1600                 1605             


Leu Ser  Ala Val Pro Pro Ser  Gln Glu Glu Arg Pro  Gly Pro Ala 
    1610                 1615                 1620             


Pro Xaa  Asn Leu Ala Arg Gln  Pro Pro Ser Arg Asn  Lys Pro Tyr 
    1625                 1630                 1635             


Ile Ser  Trp Pro Ser Ser Gly  Gly Ser Glu Pro Ser  Val Xaa Val 
    1640                 1645                 1650             


Pro Leu  Arg Ser Met Ser Asp  Pro Asp Gln Asp Phe  Asp Lys Glu 
    1655                 1660                 1665             


Pro Asp  Ser Asp Ser Xaa Lys  His Ser Xaa Pro Ser  Asn Ser Ser 
    1670                 1675                 1680             


Asn Pro  Ser Gly Pro Pro Ser  Pro Asn Ser Pro His  Arg Ser Gln 
    1685                 1690                 1695             


Leu Pro  Leu Glu Gly Leu Glu  Gln Pro Ala Cys Asp  Xaa 
    1700                 1705                 1710     


<210> 5651
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<400> 5651
Xaa Ala Cys Phe Arg Glu Glu Arg Asp Val Leu Val Asn Gly Asp Cys 
1               5                   10                  15      


Gln Trp Ile Xaa Ala Leu His Tyr Ala Phe Gln Asp Glu Asn His Leu 
            20                  25                  30          


Tyr Leu Val Met Asp Tyr Tyr Val Gly Gly Asp Leu Leu Xaa Leu Leu 
        35                  40                  45              


Ser Lys Phe Glu Asp Lys Leu Pro Glu Asp Met Ala Arg Phe Tyr Ile 
    50                  55                  60                  


Gly Glu Met Val Leu Ala Ile Asp Ser Ile His Gln Leu His Tyr Val 
65                  70                  75                  80  


His Arg Asp Ile Lys Pro Asp Asn Val Leu Leu Asp Val Asn Gly His 
                85                  90                  95      


Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu Lys Met Asn Asp Asp Gly 
            100                 105                 110         


Xaa Val Gly Ile Phe Val Gly Asp Phe Pro Phe Gly Phe Gly Phe Gly 
        115                 120                 125             


Ile 
    


<210> 5652
<211> 667
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<400> 5652
Xaa Ala Leu Gln Lys Glu Ile Leu Met Leu Lys Asp Lys Leu Glu Lys 
1               5                   10                  15      


Ser Lys Arg Glu Arg His Asn Glu Met Glu Glu Ala Val Gly Xaa Ile 
            20                  25                  30          


Lys Asp Lys Tyr Glu Arg Glu Arg Ala Met Leu Phe Asp Glu Asn Lys 
        35                  40                  45              


Lys Leu Xaa Ala Glu Asn Glu Lys Leu Cys Ser Phe Val Asp Lys Leu 
    50                  55                  60                  


Xaa Ala Gln Asn Arg Gln Leu Glu Asp Glu Leu Gln Asp Leu Ala Ala 
65                  70                  75                  80  


Lys Lys Glu Ser Val Ala His Trp Glu Ala Gln Ile Ala Glu Ile Ile 
                85                  90                  95      


Gln Trp Val Ser Asp Glu Lys Asp Ala Arg Gly Tyr Leu Gln Ala Leu 
            100                 105                 110         


Ala Ser Lys Met Xaa Glu Glu Leu Glu Ala Leu Arg Ser Ser Ser Leu 
        115                 120                 125             


Gly Ser Arg Xaa Leu Asp Pro Leu Trp Lys Val Arg Arg Ser Gln Lys 
    130                 135                 140                 


Leu Asp Met Ser Ala Arg Leu Glu Leu Gln Ser Ala Leu Glu Ala Glu 
145                 150                 155                 160 


Ile Arg Ala Lys Gln Leu Val Gln Glu Glu Leu Arg Lys Val Lys Asp 
                165                 170                 175     


Ala Asn Leu Xaa Leu Glu Ser Lys Leu Lys Asp Ser Glu Ala Lys Asn 
            180                 185                 190         


Arg Glu Leu Leu Glu Glu Met Glu Ile Leu Lys Lys Lys Met Glu Glu 
        195                 200                 205             


Lys Phe Arg Ala Asp Xaa Gly Leu Lys Leu Pro Asp Phe Gln Asp Ser 
    210                 215                 220                 


Ile Phe Glu Tyr Phe Asn Xaa Ala Pro Leu Ala His Asp Leu Xaa Phe 
225                 230                 235                 240 


Arg Xaa Ser Ser Ala Ser Glu Gln Glu Xaa Gln Ala Pro Lys Pro Glu 
                245                 250                 255     


Ala Ser Pro Ser Met Ser Val Ala Ala Ser Glu Gln Gln Glu Pro Lys 
            260                 265                 270         


Ala His Gln Phe Ser Ile Lys Ser Phe Ser Ser Pro Xaa Gln Cys Ser 
        275                 280                 285             


His Cys Xaa Ser Leu Met Val Gly Leu Ile Arg Gln Gly Tyr Ala Cys 
    290                 295                 300                 


Glu Val Cys Ser Phe Ala Cys His Val Ser Cys Lys Asp Gly Ala Pro 
305                 310                 315                 320 


Gln Val Cys Pro Ile Pro Pro Glu Gln Ser Lys Arg Pro Leu Gly Val 
                325                 330                 335     


Asp Val Gln Arg Gly Ile Gly Xaa Ala Tyr Lys Gly His Val Lys Val 
            340                 345                 350         


Pro Lys Pro Xaa Gly Val Lys Lys Gly Trp Gln Arg Ala Tyr Ala Val 
        355                 360                 365             


Val Cys Asp Cys Lys Leu Phe Leu Tyr Asp Leu Pro Glu Gly Lys Ser 
    370                 375                 380                 


Xaa Gln Pro Gly Val Ile Ala Ser Gln Val Leu Asp Leu Arg Asp Asp 
385                 390                 395                 400 


Glu Phe Ser Val Ser Ser Val Leu Ala Ser Asp Val Ile His Ala Xaa 
                405                 410                 415     


Arg Arg Asp Ile Pro Cys Ile Phe Arg Val Xaa Ala Ser Leu Leu Gly 
            420                 425                 430         


Ala Pro Ser Lys Xaa Ser Ser Leu Leu Ile Leu Xaa Glu Asn Glu Asn 
        435                 440                 445             


Glu Lys Arg Lys Trp Val Gly Ile Leu Glu Gly Leu Gln Ser Ile Leu 
    450                 455                 460                 


His Lys Asn Arg Leu Arg Asn Gln Val Val His Val Pro Leu Glu Ala 
465                 470                 475                 480 


Tyr Asp Ser Ser Leu Pro Leu Ile Lys Ala Ile Leu Xaa Ala Ala Ile 
                485                 490                 495     


Val Asp Ala Asp Arg Ile Ala Val Gly Leu Glu Glu Gly Leu Tyr Val 
            500                 505                 510         


Ile Glu Val Xaa Arg Asp Val Ile Val Arg Ala Ala Asp Cys Lys Lys 
        515                 520                 525             


Val His Gln Ile Glu Leu Ala Pro Arg Glu Lys Ile Val Ile Leu Leu 
    530                 535                 540                 


Cys Gly Arg Asn His His Val His Leu Tyr Pro Trp Ser Ser Leu Asp 
545                 550                 555                 560 


Gly Ala Glu Gly Ser Phe Asp Ile Lys Leu Pro Glu Xaa Lys Gly Cys 
                565                 570                 575     


Gln Leu Met Ala Xaa Ala Xaa Leu Lys Arg Asn Ser Gly Xaa Cys Leu 
            580                 585                 590         


Phe Val Ala Val Lys Arg Leu Ile Leu Cys Tyr Glu Ile Gln Arg Xaa 
        595                 600                 605             


Lys Pro Phe His Arg Lys Phe Asn Glu Ile Val Ala Pro Gly Ser Val 
    610                 615                 620                 


Gln Cys Leu Ala Val Leu Arg Asp Arg Leu Cys Val Gly Tyr Pro Ser 
625                 630                 635                 640 


Gly Phe Cys Leu Leu Ser Ile Gln Gly Asp Gly Gln Pro Leu Asn Leu 
                645                 650                 655     


Val Asn Pro Asn Asp Pro Ser Leu Ala Phe Leu 
            660                 665         


<210> 5653
<211> 1551
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1330)..(1330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1394)..(1394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1404)..(1404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1511)..(1511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1529)..(1529)
<223> Selenocysteine

<400> 5653
Met Glu Arg Arg Leu Arg Ala Leu Glu Gln Leu Ala Arg Gly Glu Ala 
1               5                   10                  15      


Gly Gly Cys Pro Gly Leu Asp Gly Leu Leu Asp Leu Leu Leu Ala Leu 
            20                  25                  30          


His His Glu Leu Ser Ser Gly Pro Leu Arg Arg Glu Arg Ser Val Ala 
        35                  40                  45              


Gln Phe Leu Ser Trp Ala Ser Pro Phe Val Ser Lys Val Lys Glu Leu 
    50                  55                  60                  


Arg Leu Gln Arg Asp Asp Phe Glu Ile Leu Lys Val Ile Gly Arg Gly 
65                  70                  75                  80  


Ala Phe Gly Glu Val Xaa Val Val Arg Gln Arg Asp Xaa Gly Gln Ile 
                85                  90                  95      


Phe Ala Met Lys Met Leu His Lys Trp Glu Met Leu Lys Arg Ala Glu 
            100                 105                 110         


Xaa Ala Cys Phe Arg Glu Glu Arg Asp Val Leu Val Lys Gly Asp Ser 
        115                 120                 125             


Arg Trp Val Xaa Xaa Leu His Tyr Ala Phe Gln Asp Glu Glu Tyr Leu 
    130                 135                 140                 


Tyr Leu Val Met Asp Tyr Tyr Ala Gly Gly Asp Leu Leu Xaa Leu Leu 
145                 150                 155                 160 


Ser Arg Phe Glu Asp Arg Leu Pro Pro Glu Leu Ala Gln Phe Tyr Leu 
                165                 170                 175     


Ala Glu Met Val Leu Ala Ile His Ser Leu His Gln Leu Gly Tyr Val 
            180                 185                 190         


His Arg Asp Val Lys Pro Asp Asn Val Leu Leu Asp Val Asn Gly His 
        195                 200                 205             


Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu Arg Leu Asn Xaa Asn Gly 
    210                 215                 220                 


Met Val Asp Ser Ser Val Ala Val Gly Xaa Pro Asp Tyr Ile Ser Pro 
225                 230                 235                 240 


Glu Ile Leu Gln Ala Met Glu Glu Gly Lys Gly His Tyr Gly Pro Gln 
                245                 250                 255     


Cys Asp Trp Trp Ser Leu Gly Val Cys Ala Tyr Glu Leu Leu Phe Gly 
            260                 265                 270         


Glu Xaa Pro Phe Tyr Ala Glu Ser Leu Val Glu Xaa Tyr Gly Lys Ile 
        275                 280                 285             


Met Asn His Glu Asp His Leu Gln Phe Pro Pro Asp Val Pro Asp Val 
    290                 295                 300                 


Pro Ala Ser Ala Gln Asp Leu Ile Arg Gln Leu Leu Cys Arg Gln Glu 
305                 310                 315                 320 


Glu Arg Leu Gly Arg Gly Gly Leu Asp Asp Phe Arg Asn His Pro Phe 
                325                 330                 335     


Phe Glu Gly Val Asp Trp Glu Arg Leu Ala Ser Ser Xaa Ala Pro Tyr 
            340                 345                 350         


Ile Pro Glu Leu Arg Gly Pro Met Asp Xaa Ser Asn Phe Asp Val Asp 
        355                 360                 365             


Asp Asp Xaa Leu Asn His Pro Gly Xaa Leu Pro Pro Pro Ser His Gly 
    370                 375                 380                 


Ala Phe Ser Gly His His Leu Pro Phe Val Gly Phe Xaa Tyr Xaa Ser 
385                 390                 395                 400 


Gly Ser His Ser Pro Glu Ser Ser Ser Glu Ala Trp Ala Ala Leu Glu 
                405                 410                 415     


Arg Lys Leu Gln Cys Leu Glu Gln Glu Lys Val Glu Leu Ser Arg Lys 
            420                 425                 430         


His Gln Glu Ala Leu His Ala Pro Xaa Asp His Arg Glu Leu Glu Gln 
        435                 440                 445             


Leu Arg Lys Glu Val Gln Xaa Leu Arg Asp Arg Leu Pro Glu Met Leu 
    450                 455                 460                 


Arg Asp Lys Ala Ser Leu Ser Gln Xaa Asp Gly Pro Pro Ala Gly Ser 
465                 470                 475                 480 


Pro Gly Gln Asp Ser Asp Leu Arg Gln Glu Leu Asp Arg Leu His Arg 
                485                 490                 495     


Glu Leu Ala Glu Gly Arg Ala Gly Leu Gln Ala Gln Glu Gln Glu Leu 
            500                 505                 510         


Cys Arg Ala Gln Gly Gln Gln Glu Glu Leu Leu Gln Arg Leu Gln Glu 
        515                 520                 525             


Ala Gln Glu Arg Glu Ala Ala Xaa Ala Ser Gln Xaa Arg Ala Leu Ser 
    530                 535                 540                 


Ser Gln Leu Glu Glu Ala Arg Ala Ala Gln Arg Glu Leu Glu Ala Gln 
545                 550                 555                 560 


Val Ser Ser Leu Ser Arg Gln Val Xaa Gln Leu Gln Gly Gln Trp Glu 
                565                 570                 575     


Gln Arg Leu Glu Glu Ser Ser Gln Ala Lys Xaa Ile His Xaa Ala Ser 
            580                 585                 590         


Glu Xaa Asn Gly Met Gly Pro Pro Glu Gly Gly Pro Gln Glu Ala Gln 
        595                 600                 605             


Leu Arg Lys Glu Val Ala Ala Leu Arg Glu Gln Leu Glu Gln Ala His 
    610                 615                 620                 


Ser His Arg Pro Ser Gly Lys Glu Glu Ala Leu Cys Gln Leu Gln Glu 
625                 630                 635                 640 


Glu Asn Arg Arg Leu Ser Arg Glu Gln Glu Arg Leu Glu Ala Glu Leu 
                645                 650                 655     


Ala Gln Glu Gln Glu Ser Lys Gln Arg Leu Glu Gly Glu Arg Arg Glu 
            660                 665                 670         


Xaa Glu Ser Asn Trp Glu Ala Gln Leu Ala Asp Ile Leu Ser Trp Val 
        675                 680                 685             


Asn Asp Glu Lys Val Ser Arg Gly Tyr Leu Gln Ala Leu Ala Xaa Lys 
    690                 695                 700                 


Met Ala Glu Glu Leu Glu Ser Leu Arg Asn Val Gly Xaa Gln Xaa Leu 
705                 710                 715                 720 


Pro Ala Arg Pro Leu Asp His Gln Trp Lys Ala Arg Arg Leu Gln Lys 
                725                 730                 735     


Met Glu Ala Ser Ala Arg Leu Glu Leu Gln Ser Ala Leu Glu Ala Glu 
            740                 745                 750         


Ile Arg Ala Lys Gln Gly Leu Gln Glu Arg Leu Xaa Gln Val Gln Glu 
        755                 760                 765             


Ala Gln Leu Gln Ala Glu Arg Arg Leu Gln Glu Ala Glu Lys Gln Ser 
    770                 775                 780                 


Gln Ala Leu Gln Gln Glu Leu Ala Met Leu Arg Glu Glu Leu Arg Ala 
785                 790                 795                 800 


Arg Gly Pro Val Asp Xaa Lys Pro Ser Asn Ser Leu Ile Pro Phe Leu 
                805                 810                 815     


Ser Phe Arg Ser Ser Glu Lys Asp Ser Ala Lys Asp Pro Gly Ile Ser 
            820                 825                 830         


Gly Glu Ala Xaa Arg His Gly Gly Glu Pro Asp Leu Arg Pro Glu Gly 
        835                 840                 845             


Arg Arg Ser Leu Arg Met Gly Ala Val Phe Pro Arg Ala Pro Xaa Ala 
    850                 855                 860                 


Asn Xaa Ala Ser Xaa Glu Gly Leu Pro Ala Lys Pro Gly Ser His Xaa 
865                 870                 875                 880 


Leu Arg Pro Arg Ser Phe Pro Ser Pro Xaa Lys Cys Leu Arg Cys Xaa 
                885                 890                 895     


Ser Leu Met Leu Gly Leu Gly Arg Gln Gly Leu Gly Cys Asp Ala Cys 
            900                 905                 910         


Gly Tyr Phe Cys His Xaa Xaa Cys Ala Pro Gln Ala Pro Pro Cys Pro 
        915                 920                 925             


Val Pro Pro Asp Leu Leu Arg Xaa Ala Leu Gly Val His Pro Glu Xaa 
    930                 935                 940                 


Gly Xaa Gly Xaa Ala Tyr Glu Gly Phe Leu Ser Val Pro Arg Pro Ser 
945                 950                 955                 960 


Gly Val Arg Arg Gly Trp Gln Arg Val Phe Ala Ala Leu Ser Asp Ser 
                965                 970                 975     


Arg Leu Leu Leu Phe Asp Ala Pro Asp Leu Arg Leu Ser Pro Pro Ser 
            980                 985                 990         


Gly Ala Leu Leu Gln Val Leu Asp  Leu Arg Asp Pro Gln  Phe Ser Ala 
        995                 1000                 1005             


Xaa Pro  Val Leu Ala Ser Asp  Val Ile His Ala Gln  Ser Arg Asp 
    1010                 1015                 1020             


Leu Pro  Arg Ile Phe Arg Val  Xaa Xaa Ser Gln Leu  Ala Val Pro 
    1025                 1030                 1035             


Pro Xaa  Xaa Cys Xaa Val Leu  Leu Leu Ala Glu Ser  Glu Gly Glu 
    1040                 1045                 1050             


Arg Glu  Arg Trp Leu Gln Val  Leu Gly Glu Leu Gln  Arg Leu Leu 
    1055                 1060                 1065             


Leu Asp  Ala Arg Pro Arg Pro  Arg Pro Val Tyr Xaa  Leu Lys Glu 
    1070                 1075                 1080             


Ala Tyr  Asp Asn Gly Leu Pro  Leu Leu Pro His Xaa  Leu Cys Ala 
    1085                 1090                 1095             


Ala Ile  Leu Asp Gln Asp Arg  Leu Ala Leu Gly Xaa  Glu Glu Gly 
    1100                 1105                 1110             


Leu Phe  Val Ile His Leu Arg  Ser Asn Asp Ile Phe  Gln Val Gly 
    1115                 1120                 1125             


Glu Cys  Arg Arg Val Gln Gln  Leu Xaa Leu Ser Pro  Ser Ala Gly 
    1130                 1135                 1140             


Leu Leu  Val Val Leu Cys Gly  Arg Gly Pro Ser Val  Arg Leu Phe 
    1145                 1150                 1155             


Ala Leu  Ala Glu Leu Glu Asn  Ile Glu Val Ala Gly  Ala Lys Ile 
    1160                 1165                 1170             


Pro Glu  Ser Arg Gly Cys Gln  Val Leu Ala Ala Gly  Ser Ile Leu 
    1175                 1180                 1185             


Gln Ala  Arg Xaa Pro Val Leu  Cys Val Ala Val Lys  Arg Gln Val 
    1190                 1195                 1200             


Leu Cys  Tyr Gln Leu Gly Pro  Gly Pro Gly Pro Trp  Gln Arg Arg 
    1205                 1210                 1215             


Ile Arg  Glu Leu Gln Ala Pro  Ala Xaa Val Gln Ser  Leu Gly Leu 
    1220                 1225                 1230             


Leu Gly  Asp Arg Leu Cys Val  Gly Ala Ala Gly Gly  Phe Ala Leu 
    1235                 1240                 1245             


Tyr Pro  Leu Leu Asn Glu Ala  Ala Pro Leu Ala Leu  Gly Ala Gly 
    1250                 1255                 1260             


Leu Val  Pro Glu Glu Leu Pro  Pro Ser Arg Gly Gly  Leu Gly Glu 
    1265                 1270                 1275             


Ala Leu  Gly Ala Val Glu Leu  Ser Leu Ser Glu Phe  Leu Leu Leu 
    1280                 1285                 1290             


Phe Xaa  Xaa Ala Gly Ile Tyr  Val Asp Gly Ala Gly  Arg Lys Ser 
    1295                 1300                 1305             


Arg Gly  His Glu Leu Leu Trp  Pro Ala Ala Pro Met  Gly Trp Gly 
    1310                 1315                 1320             


Tyr Ala  Ala Pro Tyr Leu Xaa  Val Phe Ser Glu Asn  Ser Ile Asp 
    1325                 1330                 1335             


Val Phe  Asp Val Arg Arg Ala  Glu Trp Val Gln Xaa  Val Pro Leu 
    1340                 1345                 1350             


Lys Lys  Val Arg Pro Leu Asn  Pro Glu Gly Ser Leu  Phe Leu Tyr 
    1355                 1360                 1365             


Gly Xaa  Glu Lys Val Arg Leu  Xaa Tyr Leu Arg Asn  Gln Leu Ala 
    1370                 1375                 1380             


Glu Lys  Asp Glu Phe Asp Ile  Pro Asp Leu Xaa Asp  Asn Ser Arg 
    1385                 1390                 1395             


Arg Gln  Leu Phe Arg Xaa Lys  Ser Lys Arg Arg Phe  Phe Phe Arg 
    1400                 1405                 1410             


Val Ser  Glu Glu Gln Gln Lys  Gln Gln Arg Arg Glu  Met Leu Lys 
    1415                 1420                 1425             


Asp Pro  Phe Val Arg Ser Lys  Leu Ile Ser Pro Pro  Xaa Asn Phe 
    1430                 1435                 1440             


Asn His  Leu Val His Val Gly  Pro Ala Asn Gly Arg  Pro Gly Ala 
    1445                 1450                 1455             


Arg Asp  Lys Ser Pro Ala Pro  Glu Glu Lys Gly Arg  Val Ala Arg 
    1460                 1465                 1470             


Gly Ser  Gly Pro Gln Arg Pro  His Ser Phe Ser Glu  Ala Leu Arg 
    1475                 1480                 1485             


Arg Pro  Ala Ser Met Gly Ser  Glu Gly Leu Gly Gly  Asp Ala Asp 
    1490                 1495                 1500             


Pro Met  Lys Arg Lys Pro Trp  Xaa Ser Leu Ser Ser  Glu Ser Val 
    1505                 1510                 1515             


Ser Cys  Pro Gln Gly Ser Leu  Ser Pro Ala Xaa Ser  Leu Met Gln 
    1520                 1525                 1530             


Val Ser  Glu Arg Pro Arg Ser  Leu Pro Leu Ser Pro  Glu Leu Glu 
    1535                 1540                 1545             


Ser Ser  Pro 
    1550     


<210> 5654
<211> 48
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<400> 5654
Met Pro Gly Pro Gln Gly Gly Arg Gly Ala Ala Xaa Met Ser Leu Gly 
1               5                   10                  15      


Lys Leu Ser Pro Val Gly Trp Val Ser Ser Ser Gln Gly Lys Arg Arg 
            20                  25                  30          


Leu Xaa Ala Asp Met Ile Ser His Pro Leu Gly Asp Phe Arg His Xaa 
        35                  40                  45              


<210> 5655
<211> 60
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<400> 5655
Met Pro Gly Pro Gln Gly Gly Arg Gly Ala Ala Xaa Met Ser Leu Gly 
1               5                   10                  15      


Lys Leu Ser Pro Val Gly Trp Val Ser Ser Ser Gln Gly Lys Arg Arg 
            20                  25                  30          


Leu Xaa Ala Asp Met Ile Ser His Pro Leu Gly Asp Phe Arg His Xaa 
        35                  40                  45              


Met His Val Gly Arg Gly Gly Asp Val Phe Gly Asp 
    50                  55                  60  


<210> 5656
<211> 70
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<400> 5656
Met Pro Gly Pro Gln Gly Gly Arg Gly Ala Ala Xaa Met Ser Leu Gly 
1               5                   10                  15      


Lys Leu Ser Pro Val Gly Trp Val Ser Ser Ser Gln Gly Lys Arg Arg 
            20                  25                  30          


Leu Xaa Ala Asp Met Ile Ser His Pro Leu Gly Asp Phe Arg His Xaa 
        35                  40                  45              


Met His Val Gly Arg Gly Gly Asp Val Phe Gly Asp Xaa Ser Phe Leu 
    50                  55                  60                  


Ser Asn His Gly Gly Ser 
65                  70  


<210> 5657
<211> 391
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<400> 5657
Met Pro Gly Pro Gln Gly Gly Arg Gly Ala Ala Xaa Met Ser Leu Gly 
1               5                   10                  15      


Lys Leu Ser Pro Val Gly Trp Val Ser Ser Ser Gln Gly Lys Arg Arg 
            20                  25                  30          


Leu Xaa Ala Asp Met Ile Ser His Pro Leu Gly Asp Phe Arg His Xaa 
        35                  40                  45              


Met His Val Gly Arg Gly Gly Asp Val Phe Gly Asp Xaa Ser Phe Leu 
    50                  55                  60                  


Ser Asn His Gly Gly Ser Ser Gly Ser Xaa His Arg Ser Pro Arg Ser 
65                  70                  75                  80  


Phe Leu Ala Lys Lys Leu Gln Leu Val Arg Arg Val Gly Ala Pro Pro 
                85                  90                  95      


Arg Arg Met Ala Ser Pro Pro Ala Pro Ser Pro Ala Pro Pro Ala Ile 
            100                 105                 110         


Ser Pro Ile Ile Lys Asn Ala Ile Ser Leu Pro Gln Leu Asn Gln Ala 
        115                 120                 125             


Ala Tyr Asp Ser Leu Val Val Gly Lys Leu Ser Phe Asp Ser Ser Pro 
    130                 135                 140                 


Xaa Ser Ser Xaa Asp Gly His Ser Ser Tyr Gly Leu Asp Ser Gly Phe 
145                 150                 155                 160 


Cys Xaa Ile Ser Arg Leu Pro Arg Ser Glu Lys Pro His Asp Arg Asp 
                165                 170                 175     


Arg Asp Gly Ser Phe Pro Ser Glu Pro Gly Leu Arg Arg Ser Asp Ser 
            180                 185                 190         


Leu Leu Ser Phe Arg Leu Asp Leu Asp Leu Gly Pro Ser Leu Leu Ser 
        195                 200                 205             


Glu Leu Leu Gly Val Met Ser Leu Pro Glu Ala Pro Ala Ala Glu Xaa 
    210                 215                 220                 


Pro Ala Pro Ala Ala Asn Pro Pro Ala Pro Xaa Ala Asn Pro Xaa Gly 
225                 230                 235                 240 


Pro Ala Ala Asn Pro Pro Ala Xaa Xaa Ala Asn Pro Pro Ala Pro Ala 
                245                 250                 255     


Ala Asn Pro Ser Ala Pro Ala Ala Xaa Pro Xaa Gly Pro Ala Ala Asn 
            260                 265                 270         


Pro Pro Ala Pro Ala Ala Ser Ser Xaa Pro His Gly His Cys Pro Asn 
        275                 280                 285             


Gly Val Xaa Ala Gly Leu Gly Pro Val Ala Glu Val Lys Ser Ser Pro 
    290                 295                 300                 


Val Gly Gly Gly Pro Arg Gly Pro Ala Gly Pro Ala Leu Gly Arg His 
305                 310                 315                 320 


Trp Gly Ala Gly Trp Asp Gly Gly His His Tyr Pro Glu Met Asp Ala 
                325                 330                 335     


Arg Gln Glu Arg Val Glu Val Leu Pro Gln Ala Arg Ala Ser Trp Glu 
            340                 345                 350         


Ser Leu Asp Glu Glu Trp Arg Ala Pro Gln Ala Gly Ser Arg Xaa Pro 
        355                 360                 365             


Val Pro Ser Xaa Val Gln Ala Asn Xaa Phe Glu Phe Ala Asp Ala Glu 
    370                 375                 380                 


Glu Asp Asp Glu Val Lys Val 
385                 390     


<210> 5658
<211> 210
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<400> 5658
Met Ser Xaa Lys Val Pro Ile Tyr Leu Lys Arg Gly Ser Arg Lys Gly 
1               5                   10                  15      


Lys Lys Glu Lys Leu Arg Asp Leu Leu Ser Ser Asp Met Ile Ser Pro 
            20                  25                  30          


Pro Leu Gly Asp Phe Arg His Xaa Ile His Ile Gly Ser Gly Gly Gly 
        35                  40                  45              


Ser Asp Met Phe Gly Asp Ile Ser Phe Leu Gln Gly Lys Phe His Leu 
    50                  55                  60                  


Leu Pro Gly Xaa Met Val Glu Gly Pro Glu Glu Asp Gly Xaa Phe Asp 
65                  70                  75                  80  


Leu Pro Phe Gln Phe Xaa Arg Xaa Ala Xaa Val Cys Gly Arg Glu Leu 
                85                  90                  95      


Pro Asp Gly Pro Ser Pro Leu Leu Lys Asn Ala Ile Ser Leu Pro Val 
            100                 105                 110         


Ile Gly Gly Pro Gln Ala Leu Xaa Leu Pro Xaa Ala Gln Ala Pro Pro 
        115                 120                 125             


Lys Pro Pro Arg Leu His Leu Glu Xaa Pro Gln Pro Ser Pro Gln Glu 
    130                 135                 140                 


Gly Gly Ser Val Asp Ile Trp Arg Ile Pro Glu Xaa Gly Ser Pro Asn 
145                 150                 155                 160 


Ser Gly Leu Xaa Pro Glu Ser Gly Ala Glu Glu Pro Phe Leu Ser Asn 
                165                 170                 175     


Ala Ser Ser Leu Leu Ser Leu His Val Asp Leu Gly Pro Ser Ile Leu 
            180                 185                 190         


Asp Asp Val Leu Gln Ile Met Asp Gln Asp Leu Asp Ser Met Gln Ile 
        195                 200                 205             


Pro Xaa 
    210 


<210> 5659
<211> 14
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<400> 5659
Met Pro Ala Lys Xaa Pro Ile Tyr Leu Lys Ala Ala Asn Asn 
1               5                   10                  


<210> 5660
<211> 35
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<400> 5660
Met Pro Ala Lys Xaa Pro Ile Tyr Leu Lys Ala Ala Asn Asn Lys Lys 
1               5                   10                  15      


Gly Lys Lys Phe Lys Leu Arg Asp Ile Leu Ser Pro Asp Met Ile Ser 
            20                  25                  30          


Pro Pro Leu 
        35  


<210> 5661
<211> 216
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<400> 5661
Met Pro Ala Lys Xaa Pro Ile Tyr Leu Lys Ala Ala Asn Asn Lys Lys 
1               5                   10                  15      


Gly Lys Lys Phe Lys Leu Arg Asp Ile Leu Ser Pro Asp Met Ile Ser 
            20                  25                  30          


Pro Pro Leu Gly Asp Phe Arg His Xaa Ile His Ile Gly Lys Glu Gly 
        35                  40                  45              


Gln His Asp Val Phe Gly Asp Ile Ser Phe Leu Gln Gly Asn Tyr Glu 
    50                  55                  60                  


Leu Leu Pro Gly Asn Gln Glu Lys Ala His Leu Gly Gln Phe Pro Gly 
65                  70                  75                  80  


His Asn Glu Phe Phe Arg Ala Asn Ser Xaa Ser Asp Ser Val Phe Xaa 
                85                  90                  95      


Glu Xaa Pro Ser Pro Val Leu Lys Asn Ala Ile Ser Leu Pro Xaa Ile 
            100                 105                 110         


Gly Gly Ser Gln Ala Leu Met Leu Pro Leu Leu Ser Pro Val Xaa Phe 
        115                 120                 125             


Asn Ser Lys Gln Glu Ser Phe Gly Pro Ala Lys Leu Pro Arg Leu Ser 
    130                 135                 140                 


Cys Glu Pro Val Met Glu Glu Lys Ala Gln Glu Lys Ser Ser Leu Leu 
145                 150                 155                 160 


Glu Asn Gly Xaa Val His Gln Gly Asp Xaa Ser Trp Gly Ser Ser Gly 
                165                 170                 175     


Ser Ala Ser Gln Ser Ser Gln Gly Arg Asp Ser His Ser Ser Ser Leu 
            180                 185                 190         


Ser Glu Gln Tyr Pro Asp Trp Pro Ala Glu Asp Met Phe Asp His Pro 
        195                 200                 205             


Xaa Pro Cys Glu Leu Ile Lys Gly 
    210                 215     


<210> 5662
<211> 254
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<400> 5662
Met Pro Ala Lys Xaa Pro Ile Tyr Leu Lys Ala Ala Asn Asn Lys Lys 
1               5                   10                  15      


Gly Lys Lys Phe Lys Leu Arg Asp Ile Leu Ser Pro Asp Met Ile Ser 
            20                  25                  30          


Pro Pro Leu Gly Asp Phe Arg His Xaa Ile His Ile Gly Lys Glu Gly 
        35                  40                  45              


Gln His Asp Val Phe Gly Asp Ile Ser Phe Leu Gln Gly Asn Tyr Glu 
    50                  55                  60                  


Leu Leu Pro Gly Asn Gln Glu Lys Ala His Leu Gly Gln Phe Pro Gly 
65                  70                  75                  80  


His Asn Glu Phe Phe Arg Ala Asn Ser Xaa Ser Asp Ser Val Phe Xaa 
                85                  90                  95      


Glu Xaa Pro Ser Pro Val Leu Lys Asn Ala Ile Ser Leu Pro Xaa Ile 
            100                 105                 110         


Gly Gly Ser Gln Ala Leu Met Leu Pro Leu Leu Ser Pro Val Xaa Phe 
        115                 120                 125             


Asn Ser Lys Gln Glu Ser Phe Gly Pro Ala Lys Leu Pro Arg Leu Ser 
    130                 135                 140                 


Cys Glu Pro Val Met Glu Glu Lys Ala Gln Glu Lys Ser Ser Leu Leu 
145                 150                 155                 160 


Glu Asn Gly Xaa Val His Gln Gly Asp Xaa Ser Trp Gly Ser Ser Gly 
                165                 170                 175     


Ser Ala Ser Gln Ser Ser Gln Gly Arg Asp Ser His Ser Ser Ser Leu 
            180                 185                 190         


Ser Glu Gln Tyr Pro Asp Trp Pro Ala Glu Asp Met Phe Asp His Pro 
        195                 200                 205             


Xaa Pro Cys Glu Leu Ile Lys Gly Lys Xaa Lys Ser Glu Glu Ser Leu 
    210                 215                 220                 


Ser Asp Leu Xaa Gly Ser Leu Leu Ser Leu Gln Leu Asp Leu Gly Pro 
225                 230                 235                 240 


Ser Leu Leu Asp Glu Val Leu Asn Val Met Asp Lys Asn Lys 
                245                 250                 


<210> 5663
<211> 79
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<400> 5663
Met Pro Ile Leu Lys Gln Leu Val Ser Ser Ser Val His Ser Lys Arg 
1               5                   10                  15      


Arg Ser Arg Ala Asp Leu Xaa Ala Glu Met Ile Ser Ala Pro Leu Gly 
            20                  25                  30          


Asp Phe Arg His Xaa Met His Gln Leu Pro Leu Gln Leu His Leu Arg 
        35                  40                  45              


His Pro Gly Gly Ala Gln Pro Cys Leu Pro Gly Ala Gly Gln Gly Pro 
    50                  55                  60                  


Gly Cys Cys Leu Lys Xaa Ala Arg Gln Gly Val Leu Leu His Gly 
65                  70                  75                  


<210> 5664
<211> 286
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<400> 5664
Met Pro Ile Leu Lys Gln Leu Val Ser Ser Ser Val His Ser Lys Arg 
1               5                   10                  15      


Arg Ser Arg Ala Asp Leu Xaa Ala Glu Met Ile Ser Ala Pro Leu Gly 
            20                  25                  30          


Asp Phe Arg His Xaa Met His Val Gly Arg Ala Gly Asp Ala Phe Gly 
        35                  40                  45              


Asp Xaa Ser Phe Leu Asn Ser Lys Ala Ala Glu Lys Gly Xaa Ser Lys 
    50                  55                  60                  


Leu Pro Lys Ser Leu Ser Ser Ser Pro Val Lys Lys Ala Asn Asp Gly 
65                  70                  75                  80  


Glu Gly Gly Asp Glu Glu Ala Gly Xaa Glu Glu Ala Val Pro Arg Arg 
                85                  90                  95      


Asn Gly Ala Ala Gly Pro His Ser Pro Asp Pro Leu Leu Asp Glu Gln 
            100                 105                 110         


Ala Phe Gly Asp Leu Xaa Asp Leu Pro Val Val Pro Lys Ala Xaa Tyr 
        115                 120                 125             


Gly Leu Lys His Ala Glu Ser Ile Met Ser Phe His Ile Asp Leu Gly 
    130                 135                 140                 


Pro Ser Met Leu Gly Asp Val Leu Ser Ile Met Asp Lys Glu Glu Trp 
145                 150                 155                 160 


Asp Pro Glu Glu Gly Glu Gly Gly Tyr His Gly Asp Glu Gly Ala Ala 
                165                 170                 175     


Gly Xaa Ile Xaa Gln Ala Pro Pro Tyr Ala Val Ala Ala Pro Pro Leu 
            180                 185                 190         


Ala Arg Gln Glu Gly Lys Ala Gly Pro Asp Leu Pro Ser Leu Pro Ser 
        195                 200                 205             


His Ala Leu Glu Asp Glu Gly Trp Ala Ala Ala Ala Pro Ser Pro Gly 
    210                 215                 220                 


Ser Ala Arg Ser Met Gly Ser His Xaa Xaa Arg Asp Ser Ser Ser Leu 
225                 230                 235                 240 


Ser Ser Cys Xaa Ser Gly Ile Leu Glu Glu Arg Ser Pro Ala Phe Arg 
                245                 250                 255     


Gly Pro Asp Arg Ala Arg Ala Ala Val Ser Arg Gln Pro Asp Lys Glu 
            260                 265                 270         


Phe Ser Phe Met Asp Glu Glu Glu Glu Asp Glu Ile Arg Val 
        275                 280                 285     


<210> 5665
<211> 73
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 5665
Met Pro Ile Leu Lys Gln Leu Val Ser Ser Ser Val His Ser Lys Arg 
1               5                   10                  15      


Arg Ser Arg Ala Asp Leu Xaa Ala Glu Met Ile Ser Ala Pro Leu Gly 
            20                  25                  30          


Asp Phe Arg His Xaa Met His Val Gly Arg Ala Gly Asp Ala Phe Gly 
        35                  40                  45              


Asp Xaa Ser Phe Leu Asn Ser Lys Ala Gly Glu Pro Asp Gly Glu Ser 
    50                  55                  60                  


Leu Asp Glu Gln Pro Ser Ser Ser Ser 
65                  70              


<210> 5666
<211> 127
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<400> 5666
Met Pro Ile Leu Lys Gln Leu Val Ser Ser Ser Val His Ser Lys Arg 
1               5                   10                  15      


Arg Ser Arg Ala Asp Leu Xaa Ala Glu Met Ile Ser Ala Pro Leu Gly 
            20                  25                  30          


Asp Phe Arg His Xaa Met His Val Gly Arg Ala Gly Asp Ala Phe Gly 
        35                  40                  45              


Asp Xaa Ser Phe Leu Asn Ser Lys Ala Gly Glu Pro Asp Gly Glu Ser 
    50                  55                  60                  


Leu Asp Glu Gln Pro Ser Ser Ser Ser Ser Lys Arg Ser Leu Leu Ser 
65                  70                  75                  80  


Arg Lys Phe Arg Gly Ser Lys Arg Ser Gln Ser Val Xaa Arg Gly Glu 
                85                  90                  95      


Arg Glu Gln Arg Asp Met Leu Gly Ser Leu Arg Asp Ser Ala Leu Phe 
            100                 105                 110         


Val Lys Asn Ala Met Ser Leu Pro Gln Leu Asn Glu Lys Glu Ala 
        115                 120                 125         


<210> 5667
<211> 356
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<400> 5667
Met Pro Ile Leu Lys Gln Leu Val Ser Ser Ser Val His Ser Lys Arg 
1               5                   10                  15      


Arg Ser Arg Ala Asp Leu Xaa Ala Glu Met Ile Ser Ala Pro Leu Gly 
            20                  25                  30          


Asp Phe Arg His Xaa Met His Val Gly Arg Ala Gly Asp Ala Phe Gly 
        35                  40                  45              


Asp Xaa Ser Phe Leu Asn Ser Lys Ala Gly Glu Pro Asp Gly Glu Ser 
    50                  55                  60                  


Leu Asp Glu Gln Pro Ser Ser Ser Ser Ser Lys Arg Ser Leu Leu Ser 
65                  70                  75                  80  


Arg Lys Phe Arg Gly Ser Lys Arg Ser Gln Ser Val Xaa Arg Gly Glu 
                85                  90                  95      


Arg Glu Gln Arg Asp Met Leu Gly Ser Leu Arg Asp Ser Ala Leu Phe 
            100                 105                 110         


Val Lys Asn Ala Met Ser Leu Pro Gln Leu Asn Glu Lys Glu Ala Ala 
        115                 120                 125             


Glu Lys Gly Xaa Ser Lys Leu Pro Lys Ser Leu Ser Ser Ser Pro Val 
    130                 135                 140                 


Lys Lys Ala Asn Asp Gly Glu Gly Gly Asp Glu Glu Ala Gly Xaa Glu 
145                 150                 155                 160 


Glu Ala Val Pro Arg Arg Asn Gly Ala Ala Gly Pro His Ser Pro Asp 
                165                 170                 175     


Pro Leu Leu Asp Glu Gln Ala Phe Gly Asp Leu Xaa Asp Leu Pro Val 
            180                 185                 190         


Val Pro Lys Ala Xaa Tyr Gly Leu Lys His Ala Glu Ser Ile Met Ser 
        195                 200                 205             


Phe His Ile Asp Leu Gly Pro Ser Met Leu Gly Asp Val Leu Ser Ile 
    210                 215                 220                 


Met Asp Lys Glu Glu Trp Asp Pro Glu Glu Gly Glu Gly Gly Tyr His 
225                 230                 235                 240 


Gly Asp Glu Gly Ala Ala Gly Xaa Ile Xaa Gln Ala Pro Pro Tyr Ala 
                245                 250                 255     


Val Ala Ala Pro Pro Leu Ala Arg Gln Glu Gly Lys Ala Gly Pro Asp 
            260                 265                 270         


Leu Pro Ser Leu Pro Ser His Ala Leu Glu Asp Glu Gly Trp Ala Ala 
        275                 280                 285             


Ala Ala Pro Ser Pro Gly Ser Ala Arg Ser Met Gly Ser His Xaa Xaa 
    290                 295                 300                 


Arg Asp Ser Ser Ser Leu Ser Ser Cys Xaa Ser Gly Ile Leu Glu Glu 
305                 310                 315                 320 


Arg Ser Pro Ala Phe Arg Gly Pro Asp Arg Ala Arg Ala Ala Val Ser 
                325                 330                 335     


Arg Gln Pro Asp Lys Glu Phe Ser Phe Met Asp Glu Glu Glu Glu Asp 
            340                 345                 350         


Glu Ile Arg Val 
        355     


<210> 5668
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5668
Met Pro Val Leu Lys Gln Leu Gly Pro Ala Gln Pro Lys Lys Arg Pro 
1               5                   10                  15      


Asp 
    


<210> 5669
<211> 148
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 5669
Met Pro Val Leu Lys Gln Leu Gly Pro Ala Gln Pro Lys Lys Arg Pro 
1               5                   10                  15      


Asp Arg Gly Ala Leu Ser Ile Ser Ala Pro Leu Gly Asp Phe Arg His 
            20                  25                  30          


Xaa Leu His Val Gly Arg Gly Gly Asp Ala Phe Gly Asp Xaa Ser Phe 
        35                  40                  45              


Leu Ser Arg His Gly Gly Gly Pro Pro Pro Glu Pro Arg Ala Pro Pro 
    50                  55                  60                  


Ala Gly Ala Pro Arg Ser Pro Pro Pro Pro Ala Val Pro Gln Ser Ala 
65                  70                  75                  80  


Ala Pro Ser Pro Ala Asp Pro Leu Leu Ser Phe His Leu Asp Leu Gly 
                85                  90                  95      


Pro Ser Met Leu Asp Ala Val Leu Gly Val Met Asp Ala Ala Arg Pro 
            100                 105                 110         


Glu Ala Ala Ala Ala Lys Pro Asp Ala Glu Pro Arg Pro Gly Xaa Gln 
        115                 120                 125             


Pro Pro Gln Ala Arg Cys Arg Pro Asn Ala Asp Leu Glu Leu Asn Asp 
    130                 135                 140                 


Val Ile Gly Leu 
145             


<210> 5670
<211> 79
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<400> 5670
Met Ser Glu Phe Trp His Lys Leu Gly Cys Cys Val Val Glu Lys Pro 
1               5                   10                  15      


Gln Pro Lys Lys Lys Arg Arg Arg Ile Asp Arg Xaa Met Ile Gly Glu 
            20                  25                  30          


Pro Met Asn Phe Val His Leu Xaa His Ile Gly Ser Gly Glu Met Gly 
        35                  40                  45              


Ala Gly Asp Gly Leu Ala Met Xaa Gly Ala Val Gln Glu Gln Met Arg 
    50                  55                  60                  


Ser Lys Gly Asn Arg Asp Arg Pro Trp Ser Asn Ser Arg Gly Leu 
65                  70                  75                  


<210> 5671
<211> 54
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<400> 5671
His Val Gly Ser Gly Asp Leu Phe Ser Gly Met Asn Ser Pro Ser Arg 
1               5                   10                  15      


Xaa Phe Cys Ser Glu Asp Ser His Ile Gln Leu Trp Glu Ile Ile Ile 
            20                  25                  30          


Ser Leu Ile Ile Pro Ser Xaa Phe Glu Asp Tyr Gln Ile Ser Gln Gln 
        35                  40                  45              


Gln Tyr Cys Gly Leu Glu 
    50                  


<210> 5672
<211> 57
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<400> 5672
Met Ile Gly Glu Pro Xaa Asn Phe Val His Xaa Ala His Val Gly Ser 
1               5                   10                  15      


Gly Asp Leu Phe Ser Gly Met Asn Ser Val Ser Ser Ile Gln Asn Gln 
            20                  25                  30          


Met Gln Ser Lys Gly Gly Tyr Gly Gly Gly Met Pro Ala Asn Val Gln 
        35                  40                  45              


Met Gln Leu Val Asp Xaa Lys Ala Gly 
    50                  55          


<210> 5673
<211> 84
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 5673
Met Ser Glu Phe Trp Leu Cys Phe Asn Cys Cys Ile Ala Glu Gln Pro 
1               5                   10                  15      


Gln Pro Lys Arg Arg Arg Arg Ile Asp Arg Ser Met Ile Gly Glu Pro 
            20                  25                  30          


Xaa Asn Phe Val His Xaa Ala His Val Gly Ser Gly Asp Leu Phe Ser 
        35                  40                  45              


Gly Met Asn Ser Val Ser Ser Ile Gln Asn Gln Met Gln Ser Lys Gly 
    50                  55                  60                  


Gly Tyr Gly Gly Gly Met Pro Ala Asn Val Gln Met Gln Leu Val Asp 
65                  70                  75                  80  


Xaa Lys Ala Gly 
                


<210> 5674
<211> 802
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<400> 5674
Met Pro Arg Ile Met Ile Lys Gly Gly Val Trp Arg Asn Xaa Glu Asp 
1               5                   10                  15      


Glu Ile Leu Lys Ala Ala Val Met Lys Tyr Gly Lys Asn Gln Trp Ser 
            20                  25                  30          


Arg Ile Ala Ser Leu Leu His Arg Lys Ser Ala Lys Gln Cys Lys Ala 
        35                  40                  45              


Arg Trp Tyr Glu Trp Leu Asp Pro Ser Ile Lys Lys Xaa Glu Trp Ser 
    50                  55                  60                  


Arg Glu Glu Glu Glu Lys Leu Leu His Leu Ala Lys Leu Met Pro Xaa 
65                  70                  75                  80  


Gln Trp Arg Xaa Ile Ala Pro Ile Ile Gly Arg Xaa Ala Ala Gln Cys 
                85                  90                  95      


Leu Glu His Tyr Glu Phe Leu Leu Asp Lys Ala Ala Gln Arg Asp Asn 
            100                 105                 110         


Glu Glu Glu Xaa Xaa Asp Asp Pro Arg Lys Leu Lys Pro Gly Glu Ile 
        115                 120                 125             


Asp Pro Asn Pro Glu Xaa Lys Pro Ala Arg Pro Asp Pro Ile Asp Met 
    130                 135                 140                 


Asp Glu Asp Glu Leu Glu Met Leu Ser Glu Ala Arg Ala Arg Leu Ala 
145                 150                 155                 160 


Asn Xaa Gln Gly Lys Lys Ala Lys Arg Lys Ala Arg Glu Lys Gln Leu 
                165                 170                 175     


Glu Glu Ala Arg Arg Leu Ala Ala Leu Gln Lys Arg Arg Glu Leu Arg 
            180                 185                 190         


Ala Ala Gly Ile Glu Ile Gln Lys Lys Arg Lys Arg Lys Arg Gly Val 
        195                 200                 205             


Asp Tyr Asn Ala Glu Ile Pro Phe Glu Lys Lys Pro Ala Leu Gly Phe 
    210                 215                 220                 


Tyr Asp Xaa Ser Glu Glu Asn Tyr Gln Ala Leu Asp Ala Asp Phe Arg 
225                 230                 235                 240 


Lys Leu Arg Gln Gln Asp Leu Asp Gly Glu Leu Arg Ser Glu Lys Glu 
                245                 250                 255     


Gly Arg Asp Arg Lys Lys Asp Lys Gln His Leu Lys Arg Lys Lys Glu 
            260                 265                 270         


Ser Asp Leu Pro Ser Ala Ile Leu Gln Xaa Ser Gly Val Ser Glu Phe 
        275                 280                 285             


Xaa Lys Lys Arg Ser Lys Leu Val Leu Pro Ala Pro Gln Ile Ser Asp 
    290                 295                 300                 


Ala Glu Leu Gln Glu Val Val Lys Val Gly Gln Ala Ser Glu Ile Ala 
305                 310                 315                 320 


Arg Gln Xaa Ala Glu Glu Ser Gly Ile Xaa Asn Ser Ala Ser Ser Xaa 
                325                 330                 335     


Leu Leu Ser Glu Tyr Asn Val Xaa Asn Asn Ser Val Ala Leu Arg Xaa 
            340                 345                 350         


Pro Arg Xaa Pro Ala Ser Gln Asp Arg Ile Leu Gln Glu Ala Gln Asn 
        355                 360                 365             


Leu Met Ala Leu Xaa Asn Val Asp Xaa Pro Leu Lys Gly Gly Leu Asn 
    370                 375                 380                 


Xaa Pro Leu His Glu Ser Asp Phe Ser Gly Val Xaa Pro Gln Arg Gln 
385                 390                 395                 400 


Val Val Gln Xaa Pro Asn Xaa Val Leu Ser Xaa Pro Phe Arg Xaa Pro 
                405                 410                 415     


Ser Asn Gly Ala Glu Gly Leu Xaa Pro Arg Ser Gly Xaa Xaa Pro Lys 
            420                 425                 430         


Pro Val Ile Asn Ser Xaa Pro Gly Arg Xaa Pro Leu Arg Asp Lys Leu 
        435                 440                 445             


Asn Ile Asn Pro Glu Asp Gly Met Ala Asp Tyr Ser Asp Pro Ser Tyr 
    450                 455                 460                 


Val Lys Gln Met Glu Arg Glu Ser Arg Glu His Leu Arg Leu Gly Leu 
465                 470                 475                 480 


Leu Gly Leu Pro Ala Pro Lys Asn Asp Phe Glu Ile Val Leu Pro Glu 
                485                 490                 495     


Asn Ala Glu Lys Glu Leu Glu Glu Arg Glu Ile Asp Asp Xaa Tyr Ile 
            500                 505                 510         


Glu Asp Ala Ala Asp Val Asp Ala Arg Lys Gln Ala Ile Arg Asp Ala 
        515                 520                 525             


Glu Arg Val Lys Glu Met Lys Arg Met His Lys Ala Val Gln Lys Asp 
    530                 535                 540                 


Leu Pro Arg Pro Ser Glu Val Asn Glu Xaa Ile Leu Arg Pro Leu Asn 
545                 550                 555                 560 


Val Glu Pro Pro Leu Xaa Asp Leu Gln Lys Ser Glu Glu Leu Ile Lys 
                565                 570                 575     


Lys Glu Met Ile Xaa Met Leu His Tyr Asp Leu Leu His His Pro Tyr 
            580                 585                 590         


Glu Pro Ser Gly Asn Lys Lys Gly Lys Xaa Val Gly Phe Gly Xaa Asn 
        595                 600                 605             


Asn Ser Glu His Ile Xaa Tyr Leu Glu His Asn Pro Tyr Glu Lys Phe 
    610                 615                 620                 


Ser Lys Glu Glu Leu Lys Lys Ala Gln Asp Val Leu Val Gln Glu Met 
625                 630                 635                 640 


Glu Val Val Lys Gln Gly Met Ser His Gly Glu Leu Ser Ser Glu Ala 
                645                 650                 655     


Tyr Asn Gln Val Trp Glu Glu Cys Tyr Ser Gln Val Leu Tyr Leu Pro 
            660                 665                 670         


Gly Gln Ser Arg Tyr Xaa Arg Ala Asn Leu Ala Ser Lys Lys Asp Arg 
        675                 680                 685             


Ile Glu Ser Leu Glu Lys Arg Leu Glu Ile Asn Arg Gly His Met Xaa 
    690                 695                 700                 


Xaa Glu Ala Lys Arg Ala Ala Lys Met Glu Lys Lys Met Lys Ile Leu 
705                 710                 715                 720 


Leu Gly Gly Tyr Gln Ser Arg Ala Met Gly Leu Met Lys Gln Leu Asn 
                725                 730                 735     


Asp Leu Trp Asp Gln Ile Glu Gln Ala His Leu Glu Leu Arg Xaa Phe 
            740                 745                 750         


Glu Glu Leu Lys Lys His Glu Asp Ser Ala Ile Pro Arg Arg Leu Glu 
        755                 760                 765             


Cys Leu Lys Glu Asp Val Gln Arg Gln Gln Glu Arg Glu Lys Glu Leu 
    770                 775                 780                 


Gln His Arg Tyr Ala Asp Leu Leu Leu Glu Lys Glu Xaa Leu Lys Ser 
785                 790                 795                 800 


Lys Phe 
        


<210> 5675
<211> 450
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<400> 5675
Met Ala Asp Val Leu Ser Val Leu Arg Gln Tyr Asn Ile Gln Lys Lys 
1               5                   10                  15      


Glu Ile Val Val Lys Gly Asp Glu Val Ile Phe Gly Glu Phe Ser Trp 
            20                  25                  30          


Pro Lys Asn Val Lys Xaa Asn Tyr Val Val Trp Gly Xaa Gly Lys Glu 
        35                  40                  45              


Gly Gln Pro Arg Glu Tyr Tyr Xaa Leu Asp Ser Ile Leu Phe Leu Leu 
    50                  55                  60                  


Asn Asn Val His Leu Ser His Pro Val Tyr Val Arg Arg Ala Ala Xaa 
65                  70                  75                  80  


Glu Asn Ile Pro Val Val Arg Arg Pro Asp Arg Lys Asp Leu Leu Gly 
                85                  90                  95      


Tyr Leu Asn Gly Glu Ala Ser Xaa Ser Ala Ser Ile Asp Arg Ser Ala 
            100                 105                 110         


Pro Leu Glu Ile Gly Leu Gln Arg Ser Xaa Gln Val Lys Arg Ala Ala 
        115                 120                 125             


Asp Glu Val Leu Ala Glu Ala Lys Lys Pro Arg Ile Glu Asp Glu Glu 
    130                 135                 140                 


Cys Val Arg Leu Asp Lys Glu Arg Leu Ala Ala Arg Leu Glu Gly His 
145                 150                 155                 160 


Lys Glu Gly Ile Val Gln Xaa Glu Gln Ile Arg Ser Leu Ser Glu Ala 
                165                 170                 175     


Met Ser Val Glu Lys Ile Ala Ala Ile Lys Ala Lys Ile Met Ala Lys 
            180                 185                 190         


Lys Arg Ser Xaa Ile Lys Xaa Asp Leu Asp Asp Asp Ile Xaa Ala Leu 
        195                 200                 205             


Lys Gln Arg Ser Phe Val Asp Ala Glu Val Asp Val Xaa Arg Asp Ile 
    210                 215                 220                 


Val Ser Arg Glu Arg Val Trp Arg Xaa Arg Xaa Xaa Ile Leu Gln Ser 
225                 230                 235                 240 


Xaa Gly Lys Glu Gly Ala Ser Ala Arg Lys Xaa Gln Xaa Pro Ala Ala 
                245                 250                 255     


Gln Pro Val Pro Arg Pro Val Ser Gln Ala Arg Pro Pro Pro Asn Gln 
            260                 265                 270         


Lys Lys Gly Ser Arg Xaa Pro Ile Ile Ile Ile Pro Ala Ala Xaa Xaa 
        275                 280                 285             


Ser Leu Ile Xaa Met Leu Asn Ala Lys Asp Leu Leu Gln Asp Leu Lys 
    290                 295                 300                 


Phe Val Pro Ser Asp Glu Lys Lys Lys Gln Gly Cys Gln Arg Glu Asn 
305                 310                 315                 320 


Glu Xaa Leu Ile Gln Arg Arg Lys Asp Gln Met Gln Pro Gly Gly Xaa 
                325                 330                 335     


Ala Ile Ser Val Xaa Val Pro Tyr Arg Val Val Asp Gln Pro Leu Lys 
            340                 345                 350         


Leu Met Pro Gln Asp Trp Asp Arg Val Val Ala Val Phe Val Gln Gly 
        355                 360                 365             


Pro Ala Trp Gln Phe Lys Gly Trp Pro Trp Leu Leu Pro Asp Gly Ser 
    370                 375                 380                 


Pro Val Asp Ile Phe Ala Lys Ile Lys Ala Phe His Leu Lys Tyr Asp 
385                 390                 395                 400 


Glu Val Arg Leu Asp Pro Asn Val Gln Lys Trp Asp Val Xaa Val Leu 
                405                 410                 415     


Glu Leu Ser Tyr His Lys Arg His Leu Asp Arg Pro Val Phe Leu Arg 
            420                 425                 430         


Phe Trp Glu Xaa Leu Asp Arg Tyr Met Val Lys His Lys Ser His Leu 
        435                 440                 445             


Arg Phe 
    450 


<210> 5676
<211> 531
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<400> 5676
Met Ala Asp Val Leu Ser Val Leu Arg Gln Tyr Asn Ile Gln Lys Lys 
1               5                   10                  15      


Glu Ile Val Val Lys Gly Asp Glu Val Ile Phe Gly Glu Phe Ser Trp 
            20                  25                  30          


Pro Lys Asn Val Lys Xaa Asn Tyr Val Val Trp Gly Xaa Gly Lys Glu 
        35                  40                  45              


Gly Gln Pro Arg Glu Tyr Tyr Xaa Leu Asp Ser Ile Leu Phe Leu Leu 
    50                  55                  60                  


Asn Asn Val His Leu Ser His Pro Val Tyr Val Arg Arg Ala Ala Xaa 
65                  70                  75                  80  


Glu Asn Ile Pro Val Val Arg Arg Pro Asp Arg Lys Asp Leu Leu Gly 
                85                  90                  95      


Tyr Leu Asn Gly Glu Ala Ser Xaa Ser Ala Ser Ile Asp Arg Ser Ala 
            100                 105                 110         


Pro Leu Glu Ile Gly Leu Gln Arg Ser Xaa Gln Val Lys Arg Ala Ala 
        115                 120                 125             


Asp Glu Val Leu Ala Glu Ala Lys Lys Pro Arg Ile Glu Asp Glu Glu 
    130                 135                 140                 


Cys Val Arg Leu Asp Lys Glu Arg Leu Ala Ala Arg Leu Glu Gly His 
145                 150                 155                 160 


Lys Glu Gly Ile Val Gln Xaa Glu Gln Ile Arg Ser Leu Ser Glu Ala 
                165                 170                 175     


Met Ser Val Glu Lys Ile Ala Ala Ile Lys Ala Lys Ile Met Ala Lys 
            180                 185                 190         


Lys Arg Ser Xaa Ile Lys Xaa Asp Leu Asp Asp Asp Ile Xaa Ala Leu 
        195                 200                 205             


Lys Gln Arg Ser Phe Val Asp Ala Glu Val Asp Val Xaa Arg Asp Ile 
    210                 215                 220                 


Val Ser Arg Glu Arg Val Trp Arg Xaa Arg Xaa Xaa Ile Leu Gln Ser 
225                 230                 235                 240 


Xaa Gly Lys Asn Phe Ser Lys Asn Ile Phe Ala Ile Leu Gln Ser Val 
                245                 250                 255     


Lys Ala Arg Glu Glu Gly Arg Ala Pro Glu Gln Arg Pro Ala Pro Asn 
            260                 265                 270         


Ala Ala Pro Val Asp Pro Xaa Leu Arg Xaa Lys Gln Pro Ile Pro Ala 
        275                 280                 285             


Ala Tyr Asn Arg Tyr Asp Gln Glu Arg Phe Lys Gly Lys Glu Glu Xaa 
    290                 295                 300                 


Glu Gly Phe Lys Ile Asp Xaa Met Gly Xaa Tyr His Gly Met Xaa Leu 
305                 310                 315                 320 


Lys Ser Val Xaa Glu Gly Ala Ser Ala Arg Lys Xaa Gln Xaa Pro Ala 
                325                 330                 335     


Ala Gln Pro Val Pro Arg Pro Val Ser Gln Ala Arg Pro Pro Pro Asn 
            340                 345                 350         


Gln Lys Lys Gly Ser Arg Xaa Pro Ile Ile Ile Ile Pro Ala Ala Xaa 
        355                 360                 365             


Xaa Ser Leu Ile Xaa Met Leu Asn Ala Lys Asp Leu Leu Gln Asp Leu 
    370                 375                 380                 


Lys Phe Val Pro Ser Asp Glu Lys Lys Lys Gln Gly Cys Gln Arg Glu 
385                 390                 395                 400 


Asn Glu Xaa Leu Ile Gln Arg Arg Lys Asp Gln Met Gln Pro Gly Gly 
                405                 410                 415     


Xaa Ala Ile Ser Val Xaa Val Pro Tyr Arg Val Val Asp Gln Pro Leu 
            420                 425                 430         


Lys Leu Met Pro Gln Asp Trp Asp Arg Val Val Ala Val Phe Val Gln 
        435                 440                 445             


Gly Pro Ala Trp Gln Phe Lys Gly Trp Pro Trp Leu Leu Pro Asp Gly 
    450                 455                 460                 


Ser Pro Val Asp Ile Phe Ala Lys Ile Lys Ala Phe His Leu Lys Tyr 
465                 470                 475                 480 


Asp Glu Val Arg Leu Asp Pro Asn Val Gln Lys Trp Asp Val Xaa Val 
                485                 490                 495     


Leu Glu Leu Ser Tyr His Lys Arg His Leu Asp Arg Pro Val Phe Leu 
            500                 505                 510         


Arg Phe Trp Glu Xaa Leu Asp Arg Tyr Met Val Lys His Lys Ser His 
        515                 520                 525             


Leu Arg Phe 
    530     


<210> 5677
<211> 760
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<400> 5677
Met Lys Xaa Pro Pro Gly Ala Ser Ser Arg Xaa Lys Cys Ser Arg Glu 
1               5                   10                  15      


Leu Arg Ser Phe Cys Ala Phe Ser Cys Pro Arg Ala Lys Gln Pro Xaa 
            20                  25                  30          


Cys Xaa Ala Trp Phe Pro Gln Gln Glu His Pro Ser Glu Asn Gly Pro 
        35                  40                  45              


Gln Met Pro Gly Arg Asp Pro Pro Ala Ala Ser Xaa Met Gln Val Leu 
    50                  55                  60                  


Leu Leu Xaa Ser Ala Glu Asp Leu Asp Cys Xaa Pro Gly Phe Gln Gln 
65                  70                  75                  80  


Lys Val Phe His Ile Asn Gln Pro Ala Glu Phe Ile Glu Asp Gln Ser 
                85                  90                  95      


Ile Leu Asn Leu Xaa Phe Ser Asp Cys Lys Gly Asn Asp Lys Leu Arg 
            100                 105                 110         


Tyr Glu Val Ser Ser Pro Tyr Phe Lys Val Asn Ser Asp Gly Gly Leu 
        115                 120                 125             


Val Ala Leu Arg Asn Ile Xaa Ala Val Gly Lys Xaa Leu Phe Val His 
    130                 135                 140                 


Ala Arg Xaa Pro His Ala Glu Asp Met Ala Glu Leu Val Ile Val Gly 
145                 150                 155                 160 


Gly Lys Asp Ile Gln Gly Ser Leu Gln Asp Ile Phe Lys Phe Ala Arg 
                165                 170                 175     


Xaa Ser Pro Val Pro Arg Gln Lys Arg Ser Ile Val Val Ser Pro Ile 
            180                 185                 190         


Leu Ile Pro Glu Asn Gln Arg Gln Pro Phe Pro Arg Asp Val Gly Lys 
        195                 200                 205             


Val Val Asp Ser Asp Arg Pro Glu Arg Ser Lys Phe Arg Leu Xaa Gly 
    210                 215                 220                 


Lys Gly Val Asp Gln Glu Pro Lys Gly Ile Phe Arg Ile Asn Glu Asn 
225                 230                 235                 240 


Xaa Gly Ser Val Ser Val Xaa Arg Xaa Leu Asp Arg Glu Val Ile Ala 
                245                 250                 255     


Val Tyr Gln Leu Phe Val Glu Xaa Xaa Asp Val Asn Gly Lys Xaa Leu 
            260                 265                 270         


Glu Gly Pro Val Pro Leu Glu Val Ile Val Ile Asp Gln Asn Asp Asn 
        275                 280                 285             


Arg Pro Ile Phe Arg Glu Gly Pro Tyr Ile Gly His Val Met Glu Gly 
    290                 295                 300                 


Ser Pro Xaa Gly Xaa Xaa Val Met Arg Met Xaa Ala Phe Asp Ala Asp 
305                 310                 315                 320 


Asp Pro Ala Xaa Asp Asn Ala Leu Leu Arg Tyr Asn Ile Arg Gln Gln 
                325                 330                 335     


Xaa Pro Asp Lys Pro Ser Pro Asn Met Phe Tyr Ile Asp Pro Glu Lys 
            340                 345                 350         


Gly Asp Ile Val Xaa Val Val Ser Pro Ala Leu Leu Asp Arg Glu Xaa 
        355                 360                 365             


Leu Glu Asn Pro Lys Tyr Glu Leu Ile Ile Glu Ala Gln Asp Met Ala 
    370                 375                 380                 


Gly Leu Asp Val Gly Leu Xaa Gly Xaa Ala Xaa Ala Xaa Ile Met Ile 
385                 390                 395                 400 


Asp Asp Lys Asn Asp His Ser Pro Lys Phe Xaa Lys Lys Glu Phe Gln 
                405                 410                 415     


Ala Xaa Val Glu Glu Gly Ala Val Gly Val Ile Val Asn Leu Xaa Val 
            420                 425                 430         


Glu Asp Lys Asp Asp Pro Xaa Xaa Gly Ala Trp Arg Ala Ala Tyr Xaa 
        435                 440                 445             


Ile Ile Asn Gly Asn Pro Gly Gln Ser Phe Glu Ile His Xaa Asn Pro 
    450                 455                 460                 


Gln Xaa Asn Glu Gly Met Leu Ser Val Val Lys Pro Leu Asp Tyr Glu 
465                 470                 475                 480 


Ile Ser Ala Phe His Xaa Leu Leu Ile Lys Val Glu Asn Glu Asp Pro 
                485                 490                 495     


Leu Val Pro Asp Val Ser Tyr Gly Pro Ser Ser Xaa Ala Xaa Val His 
            500                 505                 510         


Ile Xaa Val Leu Asp Val Asn Glu Gly Pro Val Phe Tyr Pro Asp Pro 
        515                 520                 525             


Met Met Val Xaa Arg Gln Glu Asp Leu Ser Val Gly Ser Val Leu Leu 
    530                 535                 540                 


Xaa Val Asn Ala Xaa Asp Pro Asp Ser Leu Gln His Gln Xaa Ile Arg 
545                 550                 555                 560 


Tyr Ser Val Tyr Lys Asp Pro Ala Gly Trp Leu Asn Ile Asn Pro Ile 
                565                 570                 575     


Asn Gly Xaa Val Asp Xaa Xaa Ala Val Leu Asp Arg Glu Ser Pro Phe 
            580                 585                 590         


Val Asp Asn Ser Val Tyr Xaa Ala Leu Phe Leu Ala Ile Asp Ser Gly 
        595                 600                 605             


Asn Pro Pro Ala Xaa Gly Xaa Gly Xaa Leu Leu Ile Xaa Leu Glu Asp 
    610                 615                 620                 


Val Asn Asp Asn Ala Pro Phe Ile Tyr Pro Xaa Val Ala Glu Val Cys 
625                 630                 635                 640 


Asp Asp Ala Lys Asn Leu Ser Val Val Ile Leu Gly Ala Ser Asp Lys 
                645                 650                 655     


Asp Leu His Pro Asn Xaa Asp Pro Phe Lys Phe Glu Ile His Lys Gln 
            660                 665                 670         


Ala Val Pro Asp Lys Val Trp Lys Ile Ser Lys Ile Asn Asn Xaa His 
        675                 680                 685             


Ala Leu Val Ser Leu Leu Gln Asn Leu Asn Lys Ala Asn Tyr Asn Leu 
    690                 695                 700                 


Pro Ile Met Val Xaa Asp Ser Gly Lys Pro Pro Met Xaa Asn Ile Xaa 
705                 710                 715                 720 


Asp Leu Arg Val Gln Val Cys Ser Cys Arg Asn Ser Lys Val Asp Cys 
                725                 730                 735     


Asn Ala Ala Gly Ala Leu Arg Phe Ser Leu Pro Ser Val Leu Leu Leu 
            740                 745                 750         


Ser Leu Phe Ser Leu Ala Cys Leu 
        755                 760 


<210> 5678
<211> 37
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<400> 5678
Met Gln Pro Arg Xaa Pro Leu Val Leu Cys Val Leu Leu Ser Gln Ser 
1               5                   10                  15      


Gly Gly Pro Val Cys Lys Ser Gln Phe Gln Ala Leu Pro Leu Ala Val 
            20                  25                  30          


Gln Trp Leu Gly Val 
        35          


<210> 5679
<211> 67
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<400> 5679
Met Gln Pro Arg Xaa Pro Leu Val Leu Cys Val Leu Leu Ser Gln Xaa 
1               5                   10                  15      


Pro Val Arg Pro Xaa Ile Tyr Leu Cys Gln Asn Leu Gln Phe Ile Lys 
            20                  25                  30          


Asn Lys Ala Arg Asp Ser Asn Ser Leu Ala Asp His Lys Gly Lys Arg 
        35                  40                  45              


Ile Gln Val Asn Arg Leu Leu Pro Gly Leu Leu Phe His Asp Glu Leu 
    50                  55                  60                  


Ser Gly Ile 
65          


<210> 5680
<211> 52
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<400> 5680
Met Gln Pro Arg Xaa Pro Leu Val Leu Cys Val Leu Leu Ser Gln Val 
1               5                   10                  15      


Leu Leu Leu Xaa Ser Ala Glu Asp Leu Asp Cys Xaa Pro Gly Phe Gln 
            20                  25                  30          


Gln Lys Val Phe His Ile Asn Gln Pro Ala Glu Phe Ile Glu Asp Gln 
        35                  40                  45              


Ser Ile Leu Asn 
    50          


<210> 5681
<211> 67
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<400> 5681
Met Gln Pro Arg Xaa Pro Leu Val Leu Cys Val Leu Leu Ser Gln Val 
1               5                   10                  15      


Leu Leu Leu Xaa Ser Ala Glu Asp Leu Asp Cys Xaa Pro Gly Phe Gln 
            20                  25                  30          


Gln Lys Val Phe His Ile Asn Gln Pro Ala Glu Phe Ile Glu Asp Gln 
        35                  40                  45              


Ser Ile Leu Asn Cys Lys Gln Cys His Ser Lys Met Leu Leu Asp Ser 
    50                  55                  60                  


Ser His Ile 
65          


<210> 5682
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<400> 5682
Met Gln Pro Arg Xaa Pro Leu Val Leu Cys Val Leu Leu Ser Gln Val 
1               5                   10                  15      


Leu Leu Leu Xaa Ser Ala Glu Asp Leu Asp Cys Xaa Pro Gly Phe Gln 
            20                  25                  30          


Gln Lys Val Phe His Ile Asn Gln Pro Ala Glu Phe Ile Glu Asp Gln 
        35                  40                  45              


Ser Ile Leu Asn Leu Xaa Phe Ser Asp Cys Lys Gly Asn Asp Lys Leu 
    50                  55                  60                  


Arg Tyr Glu Val Ser Ser Pro Tyr Phe Lys Val Asn Ser Asp Gly Gly 
65                  70                  75                  80  


Leu Val Ala Leu Arg Asn Ile Xaa Ala Val Gly Lys Xaa Leu Phe Val 
                85                  90                  95      


His Ala Arg Xaa Pro His Ala Glu Asp Met Ala Glu Leu Val Ile Val 
            100                 105                 110         


Gly Gly Lys Asp Ile Gln Gly Ser Leu Gln Asp Ile Phe Lys Phe Ala 
        115                 120                 125             


Arg Xaa Ser Pro Val Pro Arg Gln Lys Arg Ser Ile Val Val Ser Pro 
    130                 135                 140                 


Ile Leu Ile Pro Glu Asn Gln Arg Gln Pro Phe Pro Arg Asp Val Gly 
145                 150                 155                 160 


Lys Met Lys Ile Trp Gln Val Leu Cys Leu Ala Arg Trp Leu Xaa 
                165                 170                 175 


<210> 5683
<211> 190
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<400> 5683
Met Gln Pro Arg Xaa Pro Leu Val Leu Cys Val Leu Leu Ser Gln Val 
1               5                   10                  15      


Leu Leu Leu Xaa Ser Ala Glu Asp Leu Asp Cys Xaa Pro Gly Phe Gln 
            20                  25                  30          


Gln Lys Val Phe His Ile Asn Gln Pro Ala Glu Phe Ile Glu Asp Gln 
        35                  40                  45              


Ser Ile Leu Asn Leu Xaa Phe Ser Asp Cys Lys Gly Asn Asp Lys Leu 
    50                  55                  60                  


Arg Tyr Glu Val Ser Ser Pro Tyr Phe Lys Val Asn Ser Asp Gly Gly 
65                  70                  75                  80  


Leu Val Ala Leu Arg Asn Ile Xaa Ala Val Gly Lys Xaa Leu Phe Val 
                85                  90                  95      


His Ala Arg Xaa Pro His Ala Glu Asp Met Ala Glu Leu Val Ile Val 
            100                 105                 110         


Gly Gly Lys Asp Ile Gln Gly Ser Leu Gln Asp Ile Phe Lys Phe Ala 
        115                 120                 125             


Arg Xaa Ser Pro Val Pro Arg Gln Lys Arg Ser Ile Val Val Ser Pro 
    130                 135                 140                 


Ile Leu Ile Pro Glu Asn Gln Arg Gln Pro Phe Pro Arg Asp Val Gly 
145                 150                 155                 160 


Lys Arg Xaa His Asn Pro Ile Asn Ser Glu Leu Leu Leu Asn Glu Gly 
                165                 170                 175     


Ile Xaa Ala Asp Leu Asn Pro Cys Ile Xaa Ile Leu Ala Ile 
            180                 185                 190 


<210> 5684
<211> 713
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<400> 5684
Met Gln Pro Arg Xaa Pro Leu Val Leu Cys Val Leu Leu Ser Gln Val 
1               5                   10                  15      


Leu Leu Leu Xaa Ser Ala Glu Asp Leu Asp Cys Xaa Pro Gly Phe Gln 
            20                  25                  30          


Gln Lys Val Phe His Ile Asn Gln Pro Ala Glu Phe Ile Glu Asp Gln 
        35                  40                  45              


Ser Ile Leu Asn Leu Xaa Phe Ser Asp Cys Lys Gly Asn Asp Lys Leu 
    50                  55                  60                  


Arg Tyr Glu Val Ser Ser Pro Tyr Phe Lys Val Asn Ser Asp Gly Gly 
65                  70                  75                  80  


Leu Val Ala Leu Arg Asn Ile Xaa Ala Val Gly Lys Xaa Leu Phe Val 
                85                  90                  95      


His Ala Arg Xaa Pro His Ala Glu Asp Met Ala Glu Leu Val Ile Val 
            100                 105                 110         


Gly Gly Lys Asp Ile Gln Gly Ser Leu Gln Asp Ile Phe Lys Phe Ala 
        115                 120                 125             


Arg Xaa Ser Pro Val Pro Arg Gln Lys Arg Ser Ile Val Val Ser Pro 
    130                 135                 140                 


Ile Leu Ile Pro Glu Asn Gln Arg Gln Pro Phe Pro Arg Asp Val Gly 
145                 150                 155                 160 


Lys Val Val Asp Ser Asp Arg Pro Glu Arg Ser Lys Phe Arg Leu Xaa 
                165                 170                 175     


Gly Lys Gly Val Asp Gln Glu Pro Lys Gly Ile Phe Arg Ile Asn Glu 
            180                 185                 190         


Asn Xaa Gly Ser Val Ser Val Xaa Arg Xaa Leu Asp Arg Glu Val Ile 
        195                 200                 205             


Ala Val Tyr Gln Leu Phe Val Glu Xaa Xaa Asp Val Asn Gly Lys Xaa 
    210                 215                 220                 


Leu Glu Gly Pro Val Pro Leu Glu Val Ile Val Ile Asp Gln Asn Asp 
225                 230                 235                 240 


Asn Arg Pro Ile Phe Arg Glu Gly Pro Tyr Ile Gly His Val Met Glu 
                245                 250                 255     


Gly Ser Pro Xaa Gly Xaa Xaa Val Met Arg Met Xaa Ala Phe Asp Ala 
            260                 265                 270         


Asp Asp Pro Ala Xaa Asp Asn Ala Leu Leu Arg Tyr Asn Ile Arg Gln 
        275                 280                 285             


Gln Xaa Pro Asp Lys Pro Ser Pro Asn Met Phe Tyr Ile Asp Pro Glu 
    290                 295                 300                 


Lys Gly Asp Ile Val Xaa Val Val Ser Pro Ala Leu Leu Asp Arg Glu 
305                 310                 315                 320 


Xaa Leu Glu Asn Pro Lys Tyr Glu Leu Ile Ile Glu Ala Gln Asp Met 
                325                 330                 335     


Ala Gly Leu Asp Val Gly Leu Xaa Gly Xaa Ala Xaa Ala Xaa Ile Met 
            340                 345                 350         


Ile Asp Asp Lys Asn Asp His Ser Pro Lys Phe Xaa Lys Lys Glu Phe 
        355                 360                 365             


Gln Ala Xaa Val Glu Glu Gly Ala Val Gly Val Ile Val Asn Leu Xaa 
    370                 375                 380                 


Val Glu Asp Lys Asp Asp Pro Xaa Xaa Gly Ala Trp Arg Ala Ala Tyr 
385                 390                 395                 400 


Xaa Ile Ile Asn Gly Asn Pro Gly Gln Ser Phe Glu Ile His Xaa Asn 
                405                 410                 415     


Pro Gln Xaa Asn Glu Gly Met Leu Ser Val Val Lys Pro Leu Asp Tyr 
            420                 425                 430         


Glu Ile Ser Ala Phe His Xaa Leu Leu Ile Lys Val Glu Asn Glu Asp 
        435                 440                 445             


Pro Leu Val Pro Asp Val Ser Tyr Gly Pro Ser Ser Xaa Ala Xaa Val 
    450                 455                 460                 


His Ile Xaa Val Leu Asp Val Asn Glu Gly Pro Val Phe Tyr Pro Asp 
465                 470                 475                 480 


Pro Met Met Val Xaa Arg Gln Glu Asp Leu Ser Val Gly Ser Val Leu 
                485                 490                 495     


Leu Xaa Val Asn Ala Xaa Asp Pro Asp Ser Leu Gln His Gln Xaa Ile 
            500                 505                 510         


Arg Tyr Ser Val Tyr Lys Asp Pro Ala Gly Trp Leu Asn Ile Asn Pro 
        515                 520                 525             


Ile Asn Gly Xaa Val Asp Xaa Xaa Ala Val Leu Asp Arg Glu Ser Pro 
    530                 535                 540                 


Phe Val Asp Asn Ser Val Tyr Xaa Ala Leu Phe Leu Ala Ile Asp Ser 
545                 550                 555                 560 


Gly Asn Pro Pro Ala Xaa Gly Xaa Gly Xaa Leu Leu Ile Xaa Leu Glu 
                565                 570                 575     


Asp Val Asn Asp Asn Ala Pro Phe Ile Tyr Pro Xaa Val Ala Glu Val 
            580                 585                 590         


Cys Asp Asp Ala Lys Asn Leu Ser Val Val Ile Leu Gly Ala Ser Asp 
        595                 600                 605             


Lys Asp Leu His Pro Asn Xaa Asp Pro Phe Lys Phe Glu Ile His Lys 
    610                 615                 620                 


Gln Ala Val Pro Asp Lys Val Trp Lys Ile Ser Lys Ile Asn Asn Xaa 
625                 630                 635                 640 


His Ala Leu Val Ser Leu Leu Gln Asn Leu Asn Lys Ala Asn Tyr Asn 
                645                 650                 655     


Leu Pro Ile Met Val Xaa Asp Ser Gly Lys Pro Pro Met Xaa Asn Ile 
            660                 665                 670         


Xaa Asp Leu Arg Val Gln Val Cys Ser Cys Arg Asn Ser Lys Val Asp 
        675                 680                 685             


Cys Asn Ala Ala Gly Ala Leu Arg Phe Ser Leu Pro Ser Val Leu Leu 
    690                 695                 700                 


Leu Ser Leu Phe Ser Leu Ala Cys Leu 
705                 710             


<210> 5685
<211> 674
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<400> 5685
Met Gln Pro Arg Xaa Pro Leu Val Leu Cys Val Leu Leu Ser Gln Val 
1               5                   10                  15      


Leu Leu Leu Xaa Ser Ala Glu Asp Leu Asp Cys Xaa Pro Gly Phe Gln 
            20                  25                  30          


Gln Lys Val Phe His Ile Asn Gln Pro Ala Glu Phe Ile Glu Asp Gln 
        35                  40                  45              


Ser Ile Leu Asn Leu Xaa Phe Ser Asp Cys Lys Gly Asn Asp Lys Leu 
    50                  55                  60                  


Arg Tyr Glu Val Ser Ser Pro Tyr Phe Lys Val Asn Ser Asp Gly Gly 
65                  70                  75                  80  


Leu Val Ala Leu Arg Asn Ile Xaa Ala Val Gly Lys Xaa Leu Phe Val 
                85                  90                  95      


His Ala Arg Xaa Pro His Ala Glu Asp Met Ala Glu Leu Val Ile Val 
            100                 105                 110         


Gly Gly Lys Asp Ile Gln Gly Ser Leu Gln Val Val Asp Ser Asp Arg 
        115                 120                 125             


Pro Glu Arg Ser Lys Phe Arg Leu Xaa Gly Lys Gly Val Asp Gln Glu 
    130                 135                 140                 


Pro Lys Gly Ile Phe Arg Ile Asn Glu Asn Xaa Gly Ser Val Ser Val 
145                 150                 155                 160 


Xaa Arg Xaa Leu Asp Arg Glu Val Ile Ala Val Tyr Gln Leu Phe Val 
                165                 170                 175     


Glu Xaa Xaa Asp Val Asn Gly Lys Xaa Leu Glu Gly Pro Val Pro Leu 
            180                 185                 190         


Glu Val Ile Val Ile Asp Gln Asn Asp Asn Arg Pro Ile Phe Arg Glu 
        195                 200                 205             


Gly Pro Tyr Ile Gly His Val Met Glu Gly Ser Pro Xaa Gly Xaa Xaa 
    210                 215                 220                 


Val Met Arg Met Xaa Ala Phe Asp Ala Asp Asp Pro Ala Xaa Asp Asn 
225                 230                 235                 240 


Ala Leu Leu Arg Tyr Asn Ile Arg Gln Gln Xaa Pro Asp Lys Pro Ser 
                245                 250                 255     


Pro Asn Met Phe Tyr Ile Asp Pro Glu Lys Gly Asp Ile Val Xaa Val 
            260                 265                 270         


Val Ser Pro Ala Leu Leu Asp Arg Glu Xaa Leu Glu Asn Pro Lys Tyr 
        275                 280                 285             


Glu Leu Ile Ile Glu Ala Gln Asp Met Ala Gly Leu Asp Val Gly Leu 
    290                 295                 300                 


Xaa Gly Xaa Ala Xaa Ala Xaa Ile Met Ile Asp Asp Lys Asn Asp His 
305                 310                 315                 320 


Ser Pro Lys Phe Xaa Lys Lys Glu Phe Gln Ala Xaa Val Glu Glu Gly 
                325                 330                 335     


Ala Val Gly Val Ile Val Asn Leu Xaa Val Glu Asp Lys Asp Asp Pro 
            340                 345                 350         


Xaa Xaa Gly Ala Trp Arg Ala Ala Tyr Xaa Ile Ile Asn Gly Asn Pro 
        355                 360                 365             


Gly Gln Ser Phe Glu Ile His Xaa Asn Pro Gln Xaa Asn Glu Gly Met 
    370                 375                 380                 


Leu Ser Val Val Lys Pro Leu Asp Tyr Glu Ile Ser Ala Phe His Xaa 
385                 390                 395                 400 


Leu Leu Ile Lys Val Glu Asn Glu Asp Pro Leu Val Pro Asp Val Ser 
                405                 410                 415     


Tyr Gly Pro Ser Ser Xaa Ala Xaa Val His Ile Xaa Val Leu Asp Val 
            420                 425                 430         


Asn Glu Gly Pro Val Phe Tyr Pro Asp Pro Met Met Val Xaa Arg Gln 
        435                 440                 445             


Glu Asp Leu Ser Val Gly Ser Val Leu Leu Xaa Val Asn Ala Xaa Asp 
    450                 455                 460                 


Pro Asp Ser Leu Gln His Gln Xaa Ile Arg Tyr Ser Val Tyr Lys Asp 
465                 470                 475                 480 


Pro Ala Gly Trp Leu Asn Ile Asn Pro Ile Asn Gly Xaa Val Asp Xaa 
                485                 490                 495     


Xaa Ala Val Leu Asp Arg Glu Ser Pro Phe Val Asp Asn Ser Val Tyr 
            500                 505                 510         


Xaa Ala Leu Phe Leu Ala Ile Asp Ser Gly Asn Pro Pro Ala Xaa Gly 
        515                 520                 525             


Xaa Gly Xaa Leu Leu Ile Xaa Leu Glu Asp Val Asn Asp Asn Ala Pro 
    530                 535                 540                 


Phe Ile Tyr Pro Xaa Val Ala Glu Val Cys Asp Asp Ala Lys Asn Leu 
545                 550                 555                 560 


Ser Val Val Ile Leu Gly Ala Ser Asp Lys Asp Leu His Pro Asn Xaa 
                565                 570                 575     


Asp Pro Phe Lys Phe Glu Ile His Lys Gln Ala Val Pro Asp Lys Val 
            580                 585                 590         


Trp Lys Ile Ser Lys Ile Asn Asn Xaa His Ala Leu Val Ser Leu Leu 
        595                 600                 605             


Gln Asn Leu Asn Lys Ala Asn Tyr Asn Leu Pro Ile Met Val Xaa Asp 
    610                 615                 620                 


Ser Gly Lys Pro Pro Met Xaa Asn Ile Xaa Asp Leu Arg Val Gln Val 
625                 630                 635                 640 


Cys Ser Cys Arg Asn Ser Lys Val Asp Cys Asn Ala Ala Gly Ala Leu 
                645                 650                 655     


Arg Phe Ser Leu Pro Ser Val Leu Leu Leu Ser Leu Phe Ser Leu Ala 
            660                 665                 670         


Cys Leu 
        


<210> 5686
<211> 56
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<400> 5686
Met Gln Pro Arg Xaa Pro Leu Val Leu Cys Val Leu Leu Ser Gln Val 
1               5                   10                  15      


Leu Leu Leu Xaa Ser Ala Glu Asp Leu Asp Cys Xaa Pro Gly Phe Gln 
            20                  25                  30          


Gln Lys Val Phe His Ile Asn Gln Pro Ala Glu Phe Ile Glu Asp Gln 
        35                  40                  45              


Ser Ile Leu Asn Tyr Val Phe Tyr 
    50                  55      


<210> 5687
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<400> 5687
Met Ile Leu Gln Ala His Leu His Ser Leu Cys Leu Leu Met Leu Tyr 
1               5                   10                  15      


Leu Ala Xaa Gly Tyr Gly Gln Glu Gly Lys Phe Ser Gly Pro Leu Lys 
            20                  25                  30          


Pro Met Xaa Phe Ser Ile Tyr Glu Gly Gln Glu Pro Ser Gln Ile Ile 
        35                  40                  45              


Phe Gln Phe Lys Ala Asn Pro Pro Ala Val Xaa Phe Glu Leu Xaa Gly 
    50                  55                  60                  


Glu Xaa Asp Asn Ile Phe Val Ile Glu Arg Glu Gly Leu Leu Tyr Tyr 
65                  70                  75                  80  


Asn Arg Ala Leu Asp Arg Glu Xaa Arg Ser Xaa His Asn Leu Gln Val 
                85                  90                  95      


Ala Ala Leu Asp Ala Asn Gly Ile Ile Val Glu Gly Pro Val Pro Ile 
            100                 105                 110         


Xaa Ile Lys Val Lys Asp Ile Asn Asp Asn Arg Pro Xaa Phe Leu Gln 
        115                 120                 125             


Ser Lys Tyr Glu Gly Ser Val Arg Gln Asn Ser Arg Pro Gly Lys Pro 
    130                 135                 140                 


Phe Leu Tyr 
145         


<210> 5688
<211> 832
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(795)
<223> Selenocysteine

<400> 5688
Met Ile Leu Gln Ala His Leu His Ser Leu Cys Leu Leu Met Leu Tyr 
1               5                   10                  15      


Leu Ala Xaa Gly Tyr Gly Gln Glu Gly Lys Phe Ser Gly Pro Leu Lys 
            20                  25                  30          


Pro Met Xaa Phe Ser Ile Tyr Glu Gly Gln Glu Pro Ser Gln Ile Ile 
        35                  40                  45              


Phe Gln Phe Lys Ala Asn Pro Pro Ala Val Xaa Phe Glu Leu Xaa Gly 
    50                  55                  60                  


Glu Xaa Asp Asn Ile Phe Val Ile Glu Arg Glu Gly Leu Leu Tyr Tyr 
65                  70                  75                  80  


Asn Arg Ala Leu Asp Arg Glu Xaa Arg Ser Xaa His Asn Leu Gln Val 
                85                  90                  95      


Ala Ala Leu Asp Ala Asn Gly Ile Ile Val Glu Gly Pro Val Pro Ile 
            100                 105                 110         


Xaa Ile Lys Val Lys Asp Ile Asn Asp Asn Arg Pro Xaa Phe Leu Gln 
        115                 120                 125             


Ser Lys Tyr Glu Gly Ser Val Arg Gln Asn Ser Arg Pro Gly Lys Pro 
    130                 135                 140                 


Phe Leu Tyr Val Asn Ala Xaa Asp Leu Asp Asp Pro Ala Xaa Pro Asn 
145                 150                 155                 160 


Gly Gln Leu Tyr Tyr Gln Ile Val Ile Gln Leu Pro Met Ile Asn Asn 
                165                 170                 175     


Val Met Tyr Phe Gln Ile Asn Asn Lys Xaa Gly Ala Ile Ser Leu Xaa 
            180                 185                 190         


Arg Glu Gly Ser Gln Glu Leu Asn Pro Ala Lys Asn Pro Ser Tyr Asn 
        195                 200                 205             


Leu Val Ile Ser Val Lys Asp Met Gly Gly Gln Ser Glu Asn Ser Phe 
    210                 215                 220                 


Ser Asp Xaa Xaa Ser Val Asp Ile Ile Val Xaa Glu Asn Ile Trp Lys 
225                 230                 235                 240 


Ala Pro Lys Pro Val Glu Met Val Glu Asn Ser Xaa Asp Pro His Pro 
                245                 250                 255     


Ile Lys Ile Xaa Gln Val Arg Trp Asn Asp Pro Gly Ala Gln Tyr Ser 
            260                 265                 270         


Leu Val Asp Lys Glu Lys Leu Pro Arg Phe Pro Phe Ser Ile Asp Gln 
        275                 280                 285             


Glu Gly Asp Ile Tyr Val Xaa Gln Pro Leu Asp Arg Glu Glu Lys Asp 
    290                 295                 300                 


Ala Tyr Val Phe Tyr Ala Val Ala Lys Asp Glu Tyr Gly Lys Pro Leu 
305                 310                 315                 320 


Ser Tyr Pro Leu Glu Ile His Val Lys Val Lys Asp Ile Asn Asp Asn 
                325                 330                 335     


Pro Pro Xaa Cys Pro Ser Pro Val Xaa Val Phe Glu Val Gln Glu Asn 
            340                 345                 350         


Glu Arg Leu Gly Asn Ser Ile Gly Xaa Leu Xaa Ala His Asp Arg Asp 
        355                 360                 365             


Glu Glu Asn Xaa Ala Asn Ser Phe Leu Asn Tyr Arg Ile Val Glu Gln 
    370                 375                 380                 


Xaa Pro Lys Leu Pro Met Asp Gly Leu Phe Leu Ile Gln Xaa Tyr Ala 
385                 390                 395                 400 


Gly Met Leu Gln Leu Ala Lys Gln Ser Leu Lys Lys Gln Asp Xaa Pro 
                405                 410                 415     


Gln Tyr Asn Leu Xaa Ile Glu Val Ser Asp Lys Asp Phe Lys Xaa Leu 
            420                 425                 430         


Cys Phe Val Gln Ile Asn Val Ile Asp Ile Asn Asp Gln Ile Pro Ile 
        435                 440                 445             


Phe Glu Lys Ser Asp Tyr Gly Asn Leu Xaa Leu Ala Glu Asp Xaa Asn 
    450                 455                 460                 


Ile Gly Ser Xaa Ile Leu Xaa Ile Gln Ala Xaa Asp Ala Asp Glu Pro 
465                 470                 475                 480 


Phe Xaa Gly Ser Ser Lys Ile Leu Tyr His Ile Ile Lys Gly Asp Ser 
                485                 490                 495     


Glu Gly Arg Leu Gly Val Asp Xaa Asp Pro His Xaa Asn Xaa Gly Tyr 
            500                 505                 510         


Val Ile Ile Lys Lys Pro Leu Asp Phe Glu Xaa Ala Ala Val Ser Asn 
        515                 520                 525             


Ile Val Phe Lys Ala Glu Asn Pro Glu Pro Leu Val Phe Gly Val Lys 
    530                 535                 540                 


Tyr Asn Ala Ser Ser Phe Ala Lys Phe Xaa Leu Ile Val Xaa Asp Val 
545                 550                 555                 560 


Asn Glu Ala Pro Gln Phe Ser Gln His Val Phe Gln Ala Lys Val Ser 
                565                 570                 575     


Glu Asp Val Ala Ile Gly Xaa Lys Val Gly Asn Val Xaa Ala Lys Asp 
            580                 585                 590         


Pro Glu Gly Leu Asp Ile Ser Tyr Ser Leu Arg Gly Asp Xaa Arg Gly 
        595                 600                 605             


Trp Leu Lys Ile Asp His Val Xaa Gly Glu Ile Phe Ser Val Ala Pro 
    610                 615                 620                 


Leu Asp Arg Glu Ala Gly Ser Pro Tyr Arg Val Gln Val Val Ala Xaa 
625                 630                 635                 640 


Glu Val Gly Gly Ser Ser Leu Ser Ser Val Ser Glu Phe His Leu Ile 
                645                 650                 655     


Leu Met Asp Val Asn Asp Asn Pro Pro Arg Leu Ala Lys Asp Tyr Xaa 
            660                 665                 670         


Gly Leu Phe Phe Cys His Pro Leu Ser Ala Pro Gly Ser Leu Ile Phe 
        675                 680                 685             


Glu Ala Xaa Asp Asp Asp Gln His Leu Phe Arg Gly Pro His Phe Xaa 
    690                 695                 700                 


Phe Ser Leu Gly Ser Gly Ser Leu Gln Asn Asp Trp Glu Val Ser Lys 
705                 710                 715                 720 


Ile Asn Gly Xaa His Ala Arg Leu Ser Xaa Arg His Xaa Glu Phe Glu 
                725                 730                 735     


Glu Arg Glu Tyr Val Val Leu Ile Arg Ile Asn Asp Gly Gly Arg Pro 
            740                 745                 750         


Pro Leu Glu Gly Ile Val Ser Leu Pro Val Xaa Phe Cys Ser Cys Val 
        755                 760                 765             


Glu Gly Ser Cys Phe Arg Pro Ala Gly His Gln Xaa Gly Ile Pro Xaa 
    770                 775                 780                 


Val Gly Met Ala Val Gly Ile Leu Leu Xaa Xaa Leu Leu Val Ile Gly 
785                 790                 795                 800 


Ile Ile Leu Ala Val Val Phe Ile Arg Ile Lys Lys Asp Lys Gly Lys 
                805                 810                 815     


Asp Asn Val Glu Ser Ala Gln Ala Ser Glu Val Lys Pro Leu Arg Ser 
            820                 825                 830         


<210> 5689
<211> 580
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<400> 5689
Met Ile Leu Gln Ala His Leu His Ser Leu Cys Leu Leu Met Leu Tyr 
1               5                   10                  15      


Leu Ala Xaa Gly Tyr Gly Gln Glu Gly Lys Phe Ser Gly Pro Leu Lys 
            20                  25                  30          


Pro Met Xaa Phe Ser Ile Tyr Glu Gly Gln Glu Pro Ser Gln Ile Ile 
        35                  40                  45              


Phe Gln Phe Lys Ala Asn Pro Pro Ala Val Xaa Phe Glu Leu Xaa Gly 
    50                  55                  60                  


Glu Xaa Asp Asn Ile Phe Val Ile Glu Arg Glu Gly Leu Leu Tyr Tyr 
65                  70                  75                  80  


Asn Arg Ala Leu Asp Arg Glu Xaa Arg Ser Xaa His Asn Leu Gln Val 
                85                  90                  95      


Ala Ala Leu Asp Ala Asn Gly Ile Ile Val Glu Gly Pro Val Pro Ile 
            100                 105                 110         


Xaa Ile Lys Val Lys Asp Ile Asn Asp Asn Arg Pro Xaa Phe Leu Gln 
        115                 120                 125             


Ser Lys Tyr Glu Gly Ser Val Arg Gln Asn Ser Arg Pro Gly Asn Ser 
    130                 135                 140                 


Ile Gly Xaa Leu Xaa Ala His Asp Arg Asp Glu Glu Asn Xaa Ala Asn 
145                 150                 155                 160 


Ser Phe Leu Asn Tyr Arg Ile Val Glu Gln Xaa Pro Lys Leu Pro Met 
                165                 170                 175     


Asp Gly Leu Phe Leu Ile Gln Xaa Tyr Ala Gly Met Leu Gln Leu Ala 
            180                 185                 190         


Lys Gln Ser Leu Lys Lys Gln Asp Xaa Pro Gln Tyr Asn Leu Xaa Ile 
        195                 200                 205             


Glu Val Ser Asp Lys Asp Phe Lys Xaa Leu Cys Phe Val Gln Ile Asn 
    210                 215                 220                 


Val Ile Asp Ile Asn Asp Gln Ile Pro Ile Phe Glu Lys Ser Asp Tyr 
225                 230                 235                 240 


Gly Asn Leu Xaa Leu Ala Glu Asp Xaa Asn Ile Gly Ser Xaa Ile Leu 
                245                 250                 255     


Xaa Ile Gln Ala Xaa Asp Ala Asp Glu Pro Phe Xaa Gly Ser Ser Lys 
            260                 265                 270         


Ile Leu Tyr His Ile Ile Lys Gly Asp Ser Glu Gly Arg Leu Gly Val 
        275                 280                 285             


Asp Xaa Asp Pro His Xaa Asn Xaa Gly Tyr Val Ile Ile Lys Lys Pro 
    290                 295                 300                 


Leu Asp Phe Glu Xaa Ala Ala Val Ser Asn Ile Val Phe Lys Ala Glu 
305                 310                 315                 320 


Asn Pro Glu Pro Leu Val Phe Gly Val Lys Tyr Asn Ala Ser Ser Phe 
                325                 330                 335     


Ala Lys Phe Xaa Leu Ile Val Xaa Asp Val Asn Glu Ala Pro Gln Phe 
            340                 345                 350         


Ser Gln His Val Phe Gln Ala Lys Val Ser Glu Asp Val Ala Ile Gly 
        355                 360                 365             


Xaa Lys Val Gly Asn Val Xaa Ala Lys Asp Pro Glu Gly Leu Asp Ile 
    370                 375                 380                 


Ser Tyr Ser Leu Arg Gly Asp Xaa Arg Gly Trp Leu Lys Ile Asp His 
385                 390                 395                 400 


Val Xaa Gly Glu Ile Phe Ser Val Ala Pro Leu Asp Arg Glu Ala Gly 
                405                 410                 415     


Ser Pro Tyr Arg Val Gln Val Val Ala Xaa Glu Val Gly Gly Ser Ser 
            420                 425                 430         


Leu Ser Ser Val Ser Glu Phe His Leu Ile Leu Met Asp Val Asn Asp 
        435                 440                 445             


Asn Pro Pro Arg Leu Ala Lys Asp Tyr Xaa Gly Leu Phe Phe Cys His 
    450                 455                 460                 


Pro Leu Ser Ala Pro Gly Ser Leu Ile Phe Glu Ala Xaa Asp Asp Asp 
465                 470                 475                 480 


Gln His Leu Phe Arg Gly Pro His Phe Xaa Phe Ser Leu Gly Ser Gly 
                485                 490                 495     


Ser Leu Gln Asn Asp Trp Glu Val Ser Lys Ile Asn Gly Xaa His Ala 
            500                 505                 510         


Arg Leu Ser Xaa Arg His Xaa Glu Phe Glu Glu Arg Glu Tyr Val Val 
        515                 520                 525             


Leu Ile Arg Ile Asn Asp Gly Gly Arg Pro Pro Leu Glu Gly Ile Val 
    530                 535                 540                 


Ser Leu Pro Gly Ile Ile Leu Ala Val Val Phe Ile Arg Ile Lys Lys 
545                 550                 555                 560 


Asp Lys Gly Lys Asp Asn Val Glu Ser Ala Gln Ala Ser Glu Val Lys 
                565                 570                 575     


Pro Leu Arg Ser 
            580 


<210> 5690
<211> 90
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<400> 5690
Xaa Ile Asp Ile Asn Asp Gln Ile Pro Ile Phe Glu Lys Ser Asp Tyr 
1               5                   10                  15      


Gly Asn Leu Xaa Leu Ala Glu Asp Xaa Asn Ile Gly Ser Xaa Ile Leu 
            20                  25                  30          


Xaa Ile Gln Ala Xaa Asp Ala Asp Glu Pro Phe Xaa Gly Ser Ser Lys 
        35                  40                  45              


Ile Leu Tyr His Ile Ile Lys Gly Asp Ser Glu Gly Arg Leu Gly Val 
    50                  55                  60                  


Asp Xaa Asp Pro His Xaa Asn Xaa Gly Tyr Val Ile Ile Lys Lys Leu 
65                  70                  75                  80  


Phe Xaa Glu Gly Arg His Lys Arg Leu Ala 
                85                  90  


<210> 5691
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<400> 5691
Met Cys Asn Xaa Gln Arg Met Lys Phe Ser Asn Cys Asn Gly Lys Arg 
1               5                   10                  15      


Lys Val Gln Tyr Glu Ser Ser Glu Pro Ala Asp Phe Lys Val Asp Glu 
            20                  25                  30          


Asp Gly Met Val Tyr Ala Val Arg Ser Phe Pro Leu Ser Ser Glu His 
        35                  40                  45              


Ala Lys Phe Leu Ile Tyr Ala Gln Asp Lys Glu Xaa Gln Glu Lys Trp 
    50                  55                  60                  


Gln Val Ala Val Lys Leu Ser Leu Lys Pro Xaa Leu Xaa Glu Glu Ser 
65                  70                  75                  80  


Val Lys Glu Ser Ala Glu Val Glu Glu Ile Val Phe Pro Arg Gln Phe 
                85                  90                  95      


Ser Lys His Ser Gly His Leu Gln Arg Gln Lys Arg Asp Trp Val Ile 
            100                 105                 110         


Pro Pro Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro Phe Pro Gln Glu 
        115                 120                 125             


Leu Val Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu Ser Leu Arg Tyr 
    130                 135                 140                 


Ser Val Xaa Gly Pro Gly Ala Asp Gln Pro Pro Xaa Gly Ile Phe Ile 
145                 150                 155                 160 


Ile Asn Pro Ile Ser Gly Gln Leu Ser Val Xaa Lys Pro Leu Asp Arg 
                165                 170                 175     


Glu Gln Ile Ala Arg Phe His Leu Arg Ala His Ala Val Asp Ile 
            180                 185                 190     


<210> 5692
<211> 906
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<400> 5692
Met Cys Arg Ile Ala Gly Ala Leu Arg Xaa Leu Leu Pro Leu Leu Ala 
1               5                   10                  15      


Ala Leu Leu Gln Ala Ser Val Glu Ala Ser Gly Glu Ile Ala Leu Cys 
            20                  25                  30          


Lys Xaa Gly Phe Pro Glu Asp Val Tyr Ser Ala Val Leu Ser Lys Asp 
        35                  40                  45              


Val His Glu Gly Gln Pro Leu Leu Asn Val Lys Phe Ser Asn Cys Asn 
    50                  55                  60                  


Gly Lys Arg Lys Val Gln Tyr Glu Ser Ser Glu Pro Ala Asp Phe Lys 
65                  70                  75                  80  


Val Asp Glu Asp Gly Met Val Tyr Ala Val Arg Ser Phe Pro Leu Ser 
                85                  90                  95      


Ser Glu His Ala Lys Phe Leu Ile Tyr Ala Gln Asp Lys Glu Xaa Gln 
            100                 105                 110         


Glu Lys Trp Gln Val Ala Val Lys Leu Ser Leu Lys Pro Xaa Leu Xaa 
        115                 120                 125             


Glu Glu Ser Val Lys Glu Ser Ala Glu Val Glu Glu Ile Val Phe Pro 
    130                 135                 140                 


Arg Gln Phe Ser Lys His Ser Gly His Leu Gln Arg Gln Lys Arg Asp 
145                 150                 155                 160 


Trp Val Ile Pro Pro Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro Phe 
                165                 170                 175     


Pro Gln Glu Leu Val Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu Ser 
            180                 185                 190         


Leu Arg Tyr Ser Val Xaa Gly Pro Gly Ala Asp Gln Pro Pro Xaa Gly 
        195                 200                 205             


Ile Phe Ile Ile Asn Pro Ile Ser Gly Gln Leu Ser Val Xaa Lys Pro 
    210                 215                 220                 


Leu Asp Arg Glu Gln Ile Ala Arg Phe His Leu Arg Ala His Ala Val 
225                 230                 235                 240 


Asp Ile Asn Gly Asn Gln Val Glu Asn Pro Ile Asp Ile Val Ile Asn 
                245                 250                 255     


Val Ile Asp Met Asn Asp Asn Arg Pro Glu Phe Leu His Gln Val Trp 
            260                 265                 270         


Asn Gly Xaa Val Pro Glu Gly Ser Lys Pro Gly Xaa Tyr Val Met Xaa 
        275                 280                 285             


Val Xaa Ala Ile Asp Ala Asp Asp Pro Asn Ala Leu Asn Gly Met Leu 
    290                 295                 300                 


Arg Tyr Arg Ile Val Ser Gln Ala Pro Ser Xaa Pro Ser Pro Asn Met 
305                 310                 315                 320 


Phe Xaa Ile Asn Asn Glu Xaa Gly Asp Ile Ile Xaa Val Ala Ala Gly 
                325                 330                 335     


Leu Asp Arg Glu Lys Val Gln Gln Tyr Xaa Leu Ile Ile Gln Ala Xaa 
            340                 345                 350         


Asp Met Glu Gly Asn Pro Xaa Tyr Gly Leu Ser Asn Xaa Ala Xaa Ala 
        355                 360                 365             


Val Ile Xaa Val Xaa Asp Val Asn Asp Asn Pro Pro Glu Phe Xaa Ala 
    370                 375                 380                 


Met Xaa Phe Tyr Gly Glu Val Pro Glu Asn Arg Val Asp Ile Ile Val 
385                 390                 395                 400 


Ala Asn Leu Xaa Val Xaa Asp Lys Asp Gln Pro His Xaa Pro Ala Trp 
                405                 410                 415     


Asn Ala Val Tyr Arg Ile Ser Gly Gly Asp Pro Xaa Gly Arg Phe Ala 
            420                 425                 430         


Ile Gln Xaa Asp Pro Asn Ser Asn Asp Gly Leu Val Xaa Val Val Lys 
        435                 440                 445             


Pro Ile Asp Phe Glu Xaa Asn Arg Met Phe Val Leu Xaa Val Ala Ala 
    450                 455                 460                 


Glu Asn Gln Val Pro Leu Ala Lys Gly Ile Gln His Pro Pro Gln Ser 
465                 470                 475                 480 


Xaa Ala Xaa Val Ser Val Xaa Val Ile Asp Val Asn Glu Asn Pro Tyr 
                485                 490                 495     


Phe Ala Pro Asn Pro Lys Ile Ile Arg Gln Glu Glu Gly Leu His Ala 
            500                 505                 510         


Gly Xaa Met Leu Xaa Xaa Phe Xaa Ala Gln Asp Pro Asp Arg Tyr Met 
        515                 520                 525             


Gln Gln Asn Ile Arg Tyr Xaa Lys Leu Ser Asp Pro Ala Asn Trp Leu 
    530                 535                 540                 


Lys Ile Asp Pro Val Asn Gly Gln Ile Xaa Xaa Ile Ala Val Leu Asp 
545                 550                 555                 560 


Arg Glu Ser Pro Asn Val Lys Asn Asn Ile Tyr Asn Ala Xaa Phe Leu 
                565                 570                 575     


Ala Ser Asp Asn Gly Ile Pro Pro Met Ser Gly Xaa Gly Xaa Leu Gln 
            580                 585                 590         


Ile Tyr Leu Leu Asp Ile Asn Asp Asn Ala Pro Gln Val Leu Pro Gln 
        595                 600                 605             


Glu Ala Glu Xaa Cys Glu Xaa Pro Asp Pro Asn Ser Ile Asn Ile Xaa 
    610                 615                 620                 


Ala Leu Asp Tyr Asp Ile Asp Pro Asn Ala Gly Pro Phe Ala Phe Asp 
625                 630                 635                 640 


Leu Pro Leu Ser Pro Val Xaa Ile Lys Arg Asn Trp Xaa Ile Xaa Arg 
                645                 650                 655     


Leu Asn Gly Asp Phe Ala Gln Leu Asn Leu Lys Ile Lys Phe Leu Glu 
            660                 665                 670         


Ala Gly Ile Tyr Glu Val Pro Ile Ile Ile Xaa Asp Ser Gly Asn Pro 
        675                 680                 685             


Pro Lys Ser Asn Ile Ser Ile Leu Arg Val Lys Val Cys Gln Cys Asp 
    690                 695                 700                 


Ser Asn Gly Asp Cys Xaa Asp Val Asp Arg Ile Val Gly Ala Gly Leu 
705                 710                 715                 720 


Gly Xaa Gly Ala Ile Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu Leu 
                725                 730                 735     


Ile Leu Val Leu Met Phe Val Val Trp Met Lys Arg Arg Asp Lys Glu 
            740                 745                 750         


Arg Gln Ala Lys Gln Leu Leu Ile Asp Pro Glu Asp Asp Val Arg Asp 
        755                 760                 765             


Asn Ile Leu Lys Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp 
    770                 775                 780                 


Tyr Asp Leu Ser Gln Leu Gln Gln Pro Asp Xaa Val Glu Pro Asp Ala 
785                 790                 795                 800 


Ile Lys Pro Val Gly Ile Arg Arg Met Asp Glu Arg Pro Ile His Ala 
                805                 810                 815     


Glu Pro Gln Tyr Pro Val Arg Ser Ala Ala Pro His Pro Gly Asp Ile 
            820                 825                 830         


Gly Asp Phe Ile Asn Glu Gly Leu Lys Ala Ala Asp Asn Asp Pro Xaa 
        835                 840                 845             


Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly 
    850                 855                 860                 


Ser Xaa Ala Gly Ser Leu Ser Ser Leu Asn Ser Ser Ser Ser Gly Gly 
865                 870                 875                 880 


Glu Gln Asp Tyr Asp Tyr Leu Asn Asp Trp Gly Pro Arg Phe Lys Lys 
                885                 890                 895     


Leu Ala Asp Met Tyr Gly Gly Gly Asp Asp 
            900                 905     


<210> 5693
<211> 875
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<400> 5693
Met Phe Leu Leu Arg Arg Tyr Val Cys Ile Phe Xaa Glu Lys Leu Lys 
1               5                   10                  15      


Asn Gln Ala Glu Leu Tyr Val Phe Leu Ser Val Lys Phe Ser Asn Cys 
            20                  25                  30          


Asn Gly Lys Arg Lys Val Gln Tyr Glu Ser Ser Glu Pro Ala Asp Phe 
        35                  40                  45              


Lys Val Asp Glu Asp Gly Met Val Tyr Ala Val Arg Ser Phe Pro Leu 
    50                  55                  60                  


Ser Ser Glu His Ala Lys Phe Leu Ile Tyr Ala Gln Asp Lys Glu Xaa 
65                  70                  75                  80  


Gln Glu Lys Trp Gln Val Ala Val Lys Leu Ser Leu Lys Pro Xaa Leu 
                85                  90                  95      


Xaa Glu Glu Ser Val Lys Glu Ser Ala Glu Val Glu Glu Ile Val Phe 
            100                 105                 110         


Pro Arg Gln Phe Ser Lys His Ser Gly His Leu Gln Arg Gln Lys Arg 
        115                 120                 125             


Asp Trp Val Ile Pro Pro Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro 
    130                 135                 140                 


Phe Pro Gln Glu Leu Val Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu 
145                 150                 155                 160 


Ser Leu Arg Tyr Ser Val Xaa Gly Pro Gly Ala Asp Gln Pro Pro Xaa 
                165                 170                 175     


Gly Ile Phe Ile Ile Asn Pro Ile Ser Gly Gln Leu Ser Val Xaa Lys 
            180                 185                 190         


Pro Leu Asp Arg Glu Gln Ile Ala Arg Phe His Leu Arg Ala His Ala 
        195                 200                 205             


Val Asp Ile Asn Gly Asn Gln Val Glu Asn Pro Ile Asp Ile Val Ile 
    210                 215                 220                 


Asn Val Ile Asp Met Asn Asp Asn Arg Pro Glu Phe Leu His Gln Val 
225                 230                 235                 240 


Trp Asn Gly Xaa Val Pro Glu Gly Ser Lys Pro Gly Xaa Tyr Val Met 
                245                 250                 255     


Xaa Val Xaa Ala Ile Asp Ala Asp Asp Pro Asn Ala Leu Asn Gly Met 
            260                 265                 270         


Leu Arg Tyr Arg Ile Val Ser Gln Ala Pro Ser Xaa Pro Ser Pro Asn 
        275                 280                 285             


Met Phe Xaa Ile Asn Asn Glu Xaa Gly Asp Ile Ile Xaa Val Ala Ala 
    290                 295                 300                 


Gly Leu Asp Arg Glu Lys Val Gln Gln Tyr Xaa Leu Ile Ile Gln Ala 
305                 310                 315                 320 


Xaa Asp Met Glu Gly Asn Pro Xaa Tyr Gly Leu Ser Asn Xaa Ala Xaa 
                325                 330                 335     


Ala Val Ile Xaa Val Xaa Asp Val Asn Asp Asn Pro Pro Glu Phe Xaa 
            340                 345                 350         


Ala Met Xaa Phe Tyr Gly Glu Val Pro Glu Asn Arg Val Asp Ile Ile 
        355                 360                 365             


Val Ala Asn Leu Xaa Val Xaa Asp Lys Asp Gln Pro His Xaa Pro Ala 
    370                 375                 380                 


Trp Asn Ala Val Tyr Arg Ile Ser Gly Gly Asp Pro Xaa Gly Arg Phe 
385                 390                 395                 400 


Ala Ile Gln Xaa Asp Pro Asn Ser Asn Asp Gly Leu Val Xaa Val Val 
                405                 410                 415     


Lys Pro Ile Asp Phe Glu Xaa Asn Arg Met Phe Val Leu Xaa Val Ala 
            420                 425                 430         


Ala Glu Asn Gln Val Pro Leu Ala Lys Gly Ile Gln His Pro Pro Gln 
        435                 440                 445             


Ser Xaa Ala Xaa Val Ser Val Xaa Val Ile Asp Val Asn Glu Asn Pro 
    450                 455                 460                 


Tyr Phe Ala Pro Asn Pro Lys Ile Ile Arg Gln Glu Glu Gly Leu His 
465                 470                 475                 480 


Ala Gly Xaa Met Leu Xaa Xaa Phe Xaa Ala Gln Asp Pro Asp Arg Tyr 
                485                 490                 495     


Met Gln Gln Asn Ile Arg Tyr Xaa Lys Leu Ser Asp Pro Ala Asn Trp 
            500                 505                 510         


Leu Lys Ile Asp Pro Val Asn Gly Gln Ile Xaa Xaa Ile Ala Val Leu 
        515                 520                 525             


Asp Arg Glu Ser Pro Asn Val Lys Asn Asn Ile Tyr Asn Ala Xaa Phe 
    530                 535                 540                 


Leu Ala Ser Asp Asn Gly Ile Pro Pro Met Ser Gly Xaa Gly Xaa Leu 
545                 550                 555                 560 


Gln Ile Tyr Leu Leu Asp Ile Asn Asp Asn Ala Pro Gln Val Leu Pro 
                565                 570                 575     


Gln Glu Ala Glu Xaa Cys Glu Xaa Pro Asp Pro Asn Ser Ile Asn Ile 
            580                 585                 590         


Xaa Ala Leu Asp Tyr Asp Ile Asp Pro Asn Ala Gly Pro Phe Ala Phe 
        595                 600                 605             


Asp Leu Pro Leu Ser Pro Val Xaa Ile Lys Arg Asn Trp Xaa Ile Xaa 
    610                 615                 620                 


Arg Leu Asn Gly Asp Phe Ala Gln Leu Asn Leu Lys Ile Lys Phe Leu 
625                 630                 635                 640 


Glu Ala Gly Ile Tyr Glu Val Pro Ile Ile Ile Xaa Asp Ser Gly Asn 
                645                 650                 655     


Pro Pro Lys Ser Asn Ile Ser Ile Leu Arg Val Lys Val Cys Gln Cys 
            660                 665                 670         


Asp Ser Asn Gly Asp Cys Xaa Asp Val Asp Arg Ile Val Gly Ala Gly 
        675                 680                 685             


Leu Gly Xaa Gly Ala Ile Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu 
    690                 695                 700                 


Leu Ile Leu Val Leu Met Phe Val Val Trp Met Lys Arg Arg Asp Lys 
705                 710                 715                 720 


Glu Arg Gln Ala Lys Gln Leu Leu Ile Asp Pro Glu Asp Asp Val Arg 
                725                 730                 735     


Asp Asn Ile Leu Lys Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln 
            740                 745                 750         


Asp Tyr Asp Leu Ser Gln Leu Gln Gln Pro Asp Xaa Val Glu Pro Asp 
        755                 760                 765             


Ala Ile Lys Pro Val Gly Ile Arg Arg Met Asp Glu Arg Pro Ile His 
    770                 775                 780                 


Ala Glu Pro Gln Tyr Pro Val Arg Ser Ala Ala Pro His Pro Gly Asp 
785                 790                 795                 800 


Ile Gly Asp Phe Ile Asn Glu Gly Leu Lys Ala Ala Asp Asn Asp Pro 
                805                 810                 815     


Xaa Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser 
            820                 825                 830         


Gly Ser Xaa Ala Gly Ser Leu Ser Ser Leu Asn Ser Ser Ser Ser Gly 
        835                 840                 845             


Gly Glu Gln Asp Tyr Asp Tyr Leu Asn Asp Trp Gly Pro Arg Phe Lys 
    850                 855                 860                 


Lys Leu Ala Asp Met Tyr Gly Gly Gly Asp Asp 
865                 870                 875 


<210> 5694
<211> 73
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<400> 5694
Met Val Tyr Ala Val Arg Ser Phe Pro Leu Ser Ser Glu His Ala Lys 
1               5                   10                  15      


Phe Leu Ile Tyr Ala Gln Asp Lys Glu Xaa Gln Glu Lys Trp Gln Val 
            20                  25                  30          


Ala Val Lys Leu Ser Leu Lys Pro Xaa Leu Xaa Glu Glu Ser Val Lys 
        35                  40                  45              


Glu Ser Ala Glu Val Glu Glu Ile Val Phe Pro Arg Gln Phe Ser Lys 
    50                  55                  60                  


His Ser Gly His Leu Gln Arg Gln Lys 
65                  70              


<210> 5695
<211> 120
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<400> 5695
Met Val Tyr Ala Val Arg Ser Phe Pro Leu Ser Ser Glu His Ala Lys 
1               5                   10                  15      


Phe Leu Ile Tyr Ala Gln Asp Lys Glu Xaa Gln Glu Lys Trp Gln Val 
            20                  25                  30          


Ala Val Lys Leu Ser Leu Lys Pro Xaa Leu Xaa Glu Glu Ser Val Lys 
        35                  40                  45              


Glu Ser Ala Glu Val Glu Glu Ile Val Phe Pro Arg Gln Phe Ser Lys 
    50                  55                  60                  


His Ser Gly His Leu Gln Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
65                  70                  75                  80  


Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro Phe Pro Gln Glu Leu Val 
                85                  90                  95      


Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu Ser Leu Arg Tyr Ser Val 
            100                 105                 110         


Xaa Gly Pro Gly Ala Asp Gln Pro 
        115                 120 


<210> 5696
<211> 784
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<400> 5696
Met Gly Leu Pro Arg Gly Pro Leu Ala Ser Leu Leu Leu Leu Gln Val 
1               5                   10                  15      


Cys Trp Leu Gln Cys Ala Ala Ser Glu Pro Cys Arg Ala Val Phe Arg 
            20                  25                  30          


Glu Ala Glu Val Xaa Leu Glu Ala Gly Gly Ala Glu Gln Glu Pro Gly 
        35                  40                  45              


Gln Ala Leu Gly Lys Val Phe Met Gly Cys Pro Gly Gln Glu Pro Ala 
    50                  55                  60                  


Leu Phe Ser Xaa Asp Asn Asp Asp Phe Xaa Val Arg Asn Gly Glu Xaa 
65                  70                  75                  80  


Val Gln Glu Arg Arg Ser Leu Lys Glu Arg Asn Pro Leu Lys Ile Phe 
                85                  90                  95      


Pro Ser Lys Arg Ile Leu Arg Arg His Lys Arg Asp Trp Val Val Ala 
            100                 105                 110         


Pro Ile Ser Val Pro Glu Asn Gly Lys Gly Pro Phe Pro Gln Arg Leu 
        115                 120                 125             


Asn Gln Leu Lys Ser Asn Lys Asp Arg Asp Xaa Lys Ile Phe Tyr Ser 
    130                 135                 140                 


Ile Xaa Gly Pro Gly Ala Asp Ser Pro Pro Glu Gly Val Phe Ala Val 
145                 150                 155                 160 


Glu Lys Glu Xaa Gly Trp Leu Leu Leu Asn Lys Pro Leu Asp Arg Glu 
                165                 170                 175     


Glu Ile Ala Lys Tyr Glu Leu Phe Gly His Ala Val Ser Glu Asn Gly 
            180                 185                 190         


Ala Ser Val Glu Asp Pro Met Asn Ile Ser Ile Ile Val Xaa Asp Gln 
        195                 200                 205             


Asn Asp His Lys Pro Lys Phe Xaa Gln Asp Xaa Phe Arg Gly Ser Val 
    210                 215                 220                 


Leu Glu Gly Val Leu Pro Gly Xaa Ser Val Met Gln Val Xaa Ala Xaa 
225                 230                 235                 240 


Asp Glu Asp Asp Ala Ile Tyr Xaa Tyr Asn Gly Val Val Ala Tyr Ser 
                245                 250                 255     


Ile His Ser Gln Glu Pro Lys Asp Pro His Asp Leu Met Phe Xaa Ile 
            260                 265                 270         


His Arg Ser Xaa Gly Xaa Ile Ser Val Ile Ser Ser Gly Leu Asp Arg 
        275                 280                 285             


Glu Lys Val Pro Glu Tyr Xaa Leu Xaa Ile Gln Ala Xaa Asp Met Asp 
    290                 295                 300                 


Gly Asp Gly Ser Xaa Xaa Xaa Ala Val Ala Val Val Glu Ile Leu Asp 
305                 310                 315                 320 


Ala Asn Asp Asn Ala Pro Met Phe Asp Pro Gln Lys Tyr Glu Ala His 
                325                 330                 335     


Val Pro Glu Asn Ala Val Gly His Glu Val Gln Arg Leu Xaa Val Xaa 
            340                 345                 350         


Asp Leu Asp Ala Pro Asn Ser Pro Ala Trp Arg Ala Xaa Tyr Leu Ile 
        355                 360                 365             


Met Gly Gly Asp Asp Gly Asp His Phe Xaa Ile Xaa Xaa His Pro Glu 
    370                 375                 380                 


Ser Asn Gln Gly Ile Leu Xaa Xaa Arg Lys Gly Leu Asp Phe Glu Ala 
385                 390                 395                 400 


Lys Asn Gln His Xaa Leu Tyr Val Glu Val Xaa Asn Glu Ala Pro Phe 
                405                 410                 415     


Val Leu Lys Leu Pro Xaa Ser Xaa Ala Xaa Ile Val Val His Val Glu 
            420                 425                 430         


Asp Val Asn Glu Ala Pro Val Phe Val Pro Pro Ser Lys Val Val Glu 
        435                 440                 445             


Val Gln Glu Gly Ile Pro Xaa Gly Glu Pro Val Cys Val Tyr Xaa Ala 
    450                 455                 460                 


Glu Asp Pro Asp Lys Glu Asn Gln Lys Ile Ser Tyr Arg Ile Leu Arg 
465                 470                 475                 480 


Asp Pro Ala Gly Trp Leu Ala Met Asp Pro Asp Ser Gly Gln Val Xaa 
                485                 490                 495     


Ala Val Gly Xaa Leu Asp Arg Glu Asp Glu Gln Phe Val Arg Asn Asn 
            500                 505                 510         


Ile Tyr Glu Val Met Val Leu Ala Met Asp Asn Gly Ser Pro Pro Xaa 
        515                 520                 525             


Xaa Gly Xaa Gly Xaa Leu Leu Leu Xaa Leu Ile Asp Val Asn Asp His 
    530                 535                 540                 


Gly Pro Val Pro Glu Pro Arg Gln Ile Xaa Ile Cys Asn Gln Ser Pro 
545                 550                 555                 560 


Val Arg Gln Val Leu Asn Ile Xaa Asp Lys Asp Leu Ser Pro His Xaa 
                565                 570                 575     


Ser Pro Phe Gln Ala Gln Leu Xaa Asp Asp Ser Asp Ile Tyr Trp Xaa 
            580                 585                 590         


Ala Glu Val Asn Glu Glu Gly Asp Xaa Val Val Leu Ser Leu Lys Lys 
        595                 600                 605             


Phe Leu Lys Gln Asp Xaa Tyr Asp Val His Leu Ser Leu Ser Asp His 
    610                 615                 620                 


Gly Asn Lys Glu Gln Leu Xaa Val Ile Arg Ala Xaa Val Cys Asp Cys 
625                 630                 635                 640 


His Gly His Val Glu Xaa Cys Pro Gly Pro Trp Lys Gly Gly Phe Ile 
                645                 650                 655     


Leu Pro Val Leu Gly Ala Val Leu Ala Leu Leu Phe Leu Leu Leu Val 
            660                 665                 670         


Leu Leu Leu Leu Val Arg Lys Lys Arg Lys Ile Lys Glu Pro Leu Leu 
        675                 680                 685             


Leu Pro Glu Asp Asp Xaa Arg Asp Asn Val Phe Tyr Tyr Gly Glu Glu 
    690                 695                 700                 


Gly Gly Gly Glu Glu Asp Gln Asp Tyr Asp Ile Xaa Gln Leu His Arg 
705                 710                 715                 720 


Gly Leu Glu Ala Arg Pro Glu Val Val Leu Arg Asn Asp Val Ala Pro 
                725                 730                 735     


Xaa Ile Ile Pro Xaa Pro Met Tyr Arg Pro Arg Pro Ala Asn Pro Asp 
            740                 745                 750         


Glu Ile Gly Asn Phe Ile Ile Glu Gly Arg Gly Glu Arg Gly Ser Gln 
        755                 760                 765             


Arg Gly Asn Gly Gly Leu Gln Leu Ala Arg Gly Arg Xaa Arg Arg Ser 
    770                 775                 780                 


<210> 5697
<211> 829
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<400> 5697
Met Gly Leu Pro Arg Gly Pro Leu Ala Ser Leu Leu Leu Leu Gln Val 
1               5                   10                  15      


Cys Trp Leu Gln Cys Ala Ala Ser Glu Pro Cys Arg Ala Val Phe Arg 
            20                  25                  30          


Glu Ala Glu Val Xaa Leu Glu Ala Gly Gly Ala Glu Gln Glu Pro Gly 
        35                  40                  45              


Gln Ala Leu Gly Lys Val Phe Met Gly Cys Pro Gly Gln Glu Pro Ala 
    50                  55                  60                  


Leu Phe Ser Xaa Asp Asn Asp Asp Phe Xaa Val Arg Asn Gly Glu Xaa 
65                  70                  75                  80  


Val Gln Glu Arg Arg Ser Leu Lys Glu Arg Asn Pro Leu Lys Ile Phe 
                85                  90                  95      


Pro Ser Lys Arg Ile Leu Arg Arg His Lys Arg Asp Trp Val Val Ala 
            100                 105                 110         


Pro Ile Ser Val Pro Glu Asn Gly Lys Gly Pro Phe Pro Gln Arg Leu 
        115                 120                 125             


Asn Gln Leu Lys Ser Asn Lys Asp Arg Asp Xaa Lys Ile Phe Tyr Ser 
    130                 135                 140                 


Ile Xaa Gly Pro Gly Ala Asp Ser Pro Pro Glu Gly Val Phe Ala Val 
145                 150                 155                 160 


Glu Lys Glu Xaa Gly Trp Leu Leu Leu Asn Lys Pro Leu Asp Arg Glu 
                165                 170                 175     


Glu Ile Ala Lys Tyr Glu Leu Phe Gly His Ala Val Ser Glu Asn Gly 
            180                 185                 190         


Ala Ser Val Glu Asp Pro Met Asn Ile Ser Ile Ile Val Xaa Asp Gln 
        195                 200                 205             


Asn Asp His Lys Pro Lys Phe Xaa Gln Asp Xaa Phe Arg Gly Ser Val 
    210                 215                 220                 


Leu Glu Gly Val Leu Pro Gly Xaa Ser Val Met Gln Val Xaa Ala Xaa 
225                 230                 235                 240 


Asp Glu Asp Asp Ala Ile Tyr Xaa Tyr Asn Gly Val Val Ala Tyr Ser 
                245                 250                 255     


Ile His Ser Gln Glu Pro Lys Asp Pro His Asp Leu Met Phe Xaa Ile 
            260                 265                 270         


His Arg Ser Xaa Gly Xaa Ile Ser Val Ile Ser Ser Gly Leu Asp Arg 
        275                 280                 285             


Glu Lys Val Pro Glu Tyr Xaa Leu Xaa Ile Gln Ala Xaa Asp Met Asp 
    290                 295                 300                 


Gly Asp Gly Ser Xaa Xaa Xaa Ala Val Ala Val Val Glu Ile Leu Asp 
305                 310                 315                 320 


Ala Asn Asp Asn Ala Pro Met Phe Asp Pro Gln Lys Tyr Glu Ala His 
                325                 330                 335     


Val Pro Glu Asn Ala Val Gly His Glu Val Gln Arg Leu Xaa Val Xaa 
            340                 345                 350         


Asp Leu Asp Ala Pro Asn Ser Pro Ala Trp Arg Ala Xaa Tyr Leu Ile 
        355                 360                 365             


Met Gly Gly Asp Asp Gly Asp His Phe Xaa Ile Xaa Xaa His Pro Glu 
    370                 375                 380                 


Ser Asn Gln Gly Ile Leu Xaa Xaa Arg Lys Gly Leu Asp Phe Glu Ala 
385                 390                 395                 400 


Lys Asn Gln His Xaa Leu Tyr Val Glu Val Xaa Asn Glu Ala Pro Phe 
                405                 410                 415     


Val Leu Lys Leu Pro Xaa Ser Xaa Ala Xaa Ile Val Val His Val Glu 
            420                 425                 430         


Asp Val Asn Glu Ala Pro Val Phe Val Pro Pro Ser Lys Val Val Glu 
        435                 440                 445             


Val Gln Glu Gly Ile Pro Xaa Gly Glu Pro Val Cys Val Tyr Xaa Ala 
    450                 455                 460                 


Glu Asp Pro Asp Lys Glu Asn Gln Lys Ile Ser Tyr Arg Ile Leu Arg 
465                 470                 475                 480 


Asp Pro Ala Gly Trp Leu Ala Met Asp Pro Asp Ser Gly Gln Val Xaa 
                485                 490                 495     


Ala Val Gly Xaa Leu Asp Arg Glu Asp Glu Gln Phe Val Arg Asn Asn 
            500                 505                 510         


Ile Tyr Glu Val Met Val Leu Ala Met Asp Asn Gly Ser Pro Pro Xaa 
        515                 520                 525             


Xaa Gly Xaa Gly Xaa Leu Leu Leu Xaa Leu Ile Asp Val Asn Asp His 
    530                 535                 540                 


Gly Pro Val Pro Glu Pro Arg Gln Ile Xaa Ile Cys Asn Gln Ser Pro 
545                 550                 555                 560 


Val Arg Gln Val Leu Asn Ile Xaa Asp Lys Asp Leu Ser Pro His Xaa 
                565                 570                 575     


Ser Pro Phe Gln Ala Gln Leu Xaa Asp Asp Ser Asp Ile Tyr Trp Xaa 
            580                 585                 590         


Ala Glu Val Asn Glu Glu Gly Asp Xaa Val Val Leu Ser Leu Lys Lys 
        595                 600                 605             


Phe Leu Lys Gln Asp Xaa Tyr Asp Val His Leu Ser Leu Ser Asp His 
    610                 615                 620                 


Gly Asn Lys Glu Gln Leu Xaa Val Ile Arg Ala Xaa Val Cys Asp Cys 
625                 630                 635                 640 


His Gly His Val Glu Xaa Cys Pro Gly Pro Trp Lys Gly Gly Phe Ile 
                645                 650                 655     


Leu Pro Val Leu Gly Ala Val Leu Ala Leu Leu Phe Leu Leu Leu Val 
            660                 665                 670         


Leu Leu Leu Leu Val Arg Lys Lys Arg Lys Ile Lys Glu Pro Leu Leu 
        675                 680                 685             


Leu Pro Glu Asp Asp Xaa Arg Asp Asn Val Phe Tyr Tyr Gly Glu Glu 
    690                 695                 700                 


Gly Gly Gly Glu Glu Asp Gln Asp Tyr Asp Ile Xaa Gln Leu His Arg 
705                 710                 715                 720 


Gly Leu Glu Ala Arg Pro Glu Val Val Leu Arg Asn Asp Val Ala Pro 
                725                 730                 735     


Xaa Ile Ile Pro Xaa Pro Met Tyr Arg Pro Arg Pro Ala Asn Pro Asp 
            740                 745                 750         


Glu Ile Gly Asn Phe Ile Ile Glu Asn Leu Lys Ala Ala Asn Xaa Asp 
        755                 760                 765             


Pro Xaa Ala Pro Pro Tyr Asp Xaa Leu Leu Val Phe Asp Tyr Glu Gly 
    770                 775                 780                 


Ser Gly Ser Asp Ala Ala Ser Leu Ser Ser Leu Xaa Ser Ser Ala Ser 
785                 790                 795                 800 


Asp Gln Asp Gln Asp Tyr Asp Tyr Leu Asn Glu Trp Gly Ser Arg Phe 
                805                 810                 815     


Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu Asp Asp 
            820                 825                 


<210> 5698
<211> 48
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<400> 5698
Met Gly Leu Pro Arg Gly Pro Leu Ala Ser Leu Leu Leu Leu Gln Tyr 
1               5                   10                  15      


Ser Trp Ala Ala Leu Gly Lys Ser Gln Leu Cys Leu Ala Leu Ile Met 
            20                  25                  30          


Met Xaa Ser Leu Cys Gly Met Ala Arg Gln Ser Arg Lys Glu Gly His 
        35                  40                  45              


<210> 5699
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 5699
Val Val Leu Arg Asn Asp Val Ala Pro Xaa Ile Ile Pro Xaa Pro Met 
1               5                   10                  15      


Tyr Arg Pro Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Ile 
            20                  25                  30          


Glu Val Leu Leu Leu Cys Arg Ser Pro Pro Trp Gln Glu Ala Leu Ala 
        35                  40                  45              


Xaa Gly Tyr Ser Leu Asp Pro Ala Trp Pro Val Pro Pro Phe Pro Pro 
    50                  55                  60                  


Xaa Xaa Pro Gly Lys Xaa Lys Xaa Gln Pro Phe His Lys Tyr Met Ser 
65                  70                  75                  80  


Xaa 
    


<210> 5700
<211> 73
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<400> 5700
Xaa Cys Trp Leu Gln Cys Ala Ala Ser Glu Pro Cys Arg Ala Val Phe 
1               5                   10                  15      


Arg Glu Ala Glu Val Xaa Leu Glu Ala Gly Gly Ala Glu Gln Glu Pro 
            20                  25                  30          


Gly Gln Ala Leu Gly Lys Gly Lys Lys Val Xaa Glu Gly Lys Glu Ser 
        35                  40                  45              


Ile Glu Asp Leu Pro Ile Gln Xaa Tyr Leu Xaa Lys Xaa Gln Glu Arg 
    50                  55                  60                  


Leu Gly Gly Cys Ser Asn Ile Cys Pro 
65                  70              


<210> 5701
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<400> 5701
Xaa Gly His Val Glu Xaa Cys Pro Gly Pro Trp Lys Gly Gly Phe Ile 
1               5                   10                  15      


Leu Pro Val Leu Gly Ala Val Leu Ala Leu Leu Phe Leu Leu Leu Val 
            20                  25                  30          


Leu Leu Leu Leu Val Arg Lys Lys Arg Lys Ile Lys Glu Pro Leu Leu 
        35                  40                  45              


Leu Pro Glu Asp Asp Xaa Arg Asp Asn Val Phe Tyr Tyr Gly Glu Glu 
    50                  55                  60                  


Gly Gly Gly Glu Glu Asp Gln Asp Tyr Asp Ile Xaa Gln Leu His Arg 
65                  70                  75                  80  


Gly Leu Glu Ala Arg Pro Glu Val Val Leu Arg Asn Asp Val Ala Pro 
                85                  90                  95      


Xaa Ile Ile Pro Xaa Pro Met Tyr Arg Pro Arg Pro Ala Asn Pro Asp 
            100                 105                 110         


Glu Ile Gly Asn Phe Ile Ile Glu Val Arg Arg Gly Arg Pro Val Glu 
        115                 120                 125             


Gly His Pro Leu Phe Lys Pro Ser Xaa Ser His Xaa Gly Glu Gln Ala 
    130                 135                 140                 


Trp Ala Trp Ser Leu Gly Ser Gly Phe Lys Phe 
145                 150                 155 


<210> 5702
<211> 59
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<400> 5702
Xaa Leu Asn Gln Leu Lys Ser Asn Lys Asp Arg Asp Xaa Lys Ile Phe 
1               5                   10                  15      


Tyr Ser Ile Xaa Gly Pro Gly Ala Asp Ser Pro Pro Glu Gly Val Phe 
            20                  25                  30          


Ala Val Glu Lys Glu Xaa Gly Trp Leu Leu Leu Asn Lys Pro Leu Asp 
        35                  40                  45              


Arg Glu Glu Ile Ala Lys Tyr Glu Val Leu Leu 
    50                  55                  


<210> 5703
<211> 41
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<400> 5703
Xaa Val Arg Gln Val Leu Asn Ile Xaa Asp Lys Asp Leu Ser Pro His 
1               5                   10                  15      


Xaa Ser Pro Phe Gln Ala Gln Leu Xaa Asp Asp Ser Asp Ile Tyr Trp 
            20                  25                  30          


Xaa Ala Glu Val Asn Glu Glu Gly Xaa 
        35                  40      


<210> 5704
<211> 223
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<400> 5704
Met Pro Ser Arg Xaa Gly Xaa Ser Xaa Leu Xaa Val Ala Val Cys Lys 
1               5                   10                  15      


Cys Asn Glu Gln Gly Glu Phe Xaa Phe Cys Glu Asp Met Ala Ala Gln 
            20                  25                  30          


Val Gly Val Ser Ile Gln Ala Val Val Ala Ile Leu Leu Cys Ile Leu 
        35                  40                  45              


Xaa Ile Xaa Val Ile Xaa Leu Leu Ile Phe Leu Arg Arg Arg Leu Arg 
    50                  55                  60                  


Lys Gln Ala Arg Ala His Gly Lys Ser Val Pro Glu Ile His Glu Gln 
65                  70                  75                  80  


Leu Val Xaa Tyr Asp Glu Glu Gly Gly Gly Glu Met Asp Xaa Xaa Ser 
                85                  90                  95      


Tyr Asp Val Ser Val Leu Asn Ser Val Arg Arg Gly Gly Ala Lys Pro 
            100                 105                 110         


Pro Arg Pro Ala Leu Asp Ala Arg Pro Ser Leu Tyr Ala Gln Val Gln 
        115                 120                 125             


Lys Pro Pro Arg His Ala Pro Gly Ala His Gly Gly Pro Gly Glu Met 
    130                 135                 140                 


Ala Ala Met Ile Glu Val Lys Lys Asp Glu Ala Asp His Asp Gly Asp 
145                 150                 155                 160 


Gly Pro Pro Tyr Asp Xaa Leu His Ile Tyr Gly Tyr Glu Gly Ser Glu 
                165                 170                 175     


Ser Ile Ala Glu Ser Leu Ser Ser Leu Gly Xaa Asp Ser Ser Asp Ser 
            180                 185                 190         


Asp Val Asp Tyr Asp Phe Leu Asn Asp Trp Gly Pro Arg Phe Lys Met 
        195                 200                 205             


Leu Ala Glu Leu Tyr Gly Ser Asp Pro Arg Glu Glu Leu Leu Tyr 
    210                 215                 220             


<210> 5705
<211> 17
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<400> 5705
Met Gln Arg Leu Met Met Leu Leu Ala Xaa Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu 
    


<210> 5706
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<400> 5706
Met Gln Arg Leu Met Met Leu Leu Ala Xaa Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln 
            20                  25                  30          


Arg Asp Xaa His Ser Leu Leu Pro Xaa His Arg Arg Gln Lys Arg Asp 
        35                  40                  45              


Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Xaa Ser Leu 
    50                  55                  60                  


Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser 
65                  70                  75      


<210> 5707
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 5707
Met Gln Arg Leu Met Met Leu Leu Ala Xaa Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln 
            20                  25                  30          


Arg Asp Xaa His Ser Leu Leu Pro Xaa His Arg Arg Gln Lys Arg Asp 
        35                  40                  45              


Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Xaa Ser Leu 
    50                  55                  60                  


Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val Asp 
                85                  90                  95      


Ala Glu Xaa Gly Asp Val Phe Ala Ile Glu Arg Leu Asp Arg Glu Asn 
            100                 105                 110         


Ile Ser Glu Tyr His Leu Xaa Ala Val Ile Val Asp Lys Asp Xaa Gly 
        115                 120                 125             


Glu Asn Leu 
    130     


<210> 5708
<211> 406
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<400> 5708
Met Gln Arg Leu Met Met Leu Leu Ala Xaa Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln 
            20                  25                  30          


Arg Asp Xaa His Ser Leu Leu Pro Xaa His Arg Arg Gln Lys Arg Asp 
        35                  40                  45              


Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Xaa Ser Leu 
    50                  55                  60                  


Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val Asp 
                85                  90                  95      


Ala Glu Xaa Gly Asp Val Phe Ala Ile Glu Arg Leu Asp Arg Glu Asn 
            100                 105                 110         


Ile Ser Glu Tyr His Leu Xaa Ala Val Ile Val Asp Lys Asp Xaa Gly 
        115                 120                 125             


Glu Asn Leu Glu Xaa Pro Ser Ser Phe Xaa Ile Lys Val His Asp Val 
    130                 135                 140                 


Asn Asp Asn Trp Pro Val Phe Xaa His Arg Leu Phe Asn Ala Ser Val 
145                 150                 155                 160 


Pro Glu Ser Ser Ala Val Gly Xaa Ser Val Ile Ser Val Xaa Ala Val 
                165                 170                 175     


Asp Ala Asp Asp Pro Xaa Val Gly Asp His Ala Ser Val Met Tyr Gln 
            180                 185                 190         


Ile Leu Lys Gly Lys Glu Tyr Phe Ala Ile Asp Asn Ser Gly Arg Ile 
        195                 200                 205             


Ile Xaa Ile Xaa Lys Ser Leu Asp Arg Glu Lys Gln Ala Arg Tyr Glu 
    210                 215                 220                 


Ile Val Val Glu Ala Arg Asp Ala Gln Gly Leu Arg Gly Asp Ser Gly 
225                 230                 235                 240 


Xaa Ala Xaa Val Leu Val Xaa Leu Gln Asp Ile Asn Asp Asn Phe Pro 
                245                 250                 255     


Phe Phe Xaa Gln Xaa Lys Tyr Xaa Phe Val Val Pro Glu Asp Xaa Arg 
            260                 265                 270         


Val Gly Xaa Ser Val Gly Ser Leu Phe Val Glu Asp Pro Asp Glu Pro 
        275                 280                 285             


Gln Asn Arg Met Xaa Lys Tyr Ser Ile Leu Arg Gly Asp Tyr Gln Asp 
    290                 295                 300                 


Ala Phe Xaa Ile Glu Xaa Asn Pro Ala His Asn Glu Gly Ile Ile Lys 
305                 310                 315                 320 


Pro Met Lys Pro Leu Asp Tyr Glu Tyr Ile Gln Gln Tyr Ser Phe Ile 
                325                 330                 335     


Val Glu Ala Xaa Asp Pro Xaa Ile Asp Leu Arg Tyr Met Ser Pro Pro 
            340                 345                 350         


Ala Gly Asn Arg Ala Gln Val Ile Ile Asn Ile Xaa Asp Val Asp Glu 
        355                 360                 365             


Pro Pro Ile Phe Gln Gln Pro Phe Tyr His Phe Gln Leu Lys Glu Asn 
    370                 375                 380                 


Gln Lys Lys Pro Leu Ile Gly Xaa Val Leu Ala Met Asp Pro Asp Ala 
385                 390                 395                 400 


Ala Arg His Ser Ile Gly 
                405     


<210> 5709
<211> 669
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<400> 5709
Met Gln Arg Leu Met Met Leu Leu Ala Xaa Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln 
            20                  25                  30          


Arg Asp Xaa His Ser Leu Leu Pro Xaa His Arg Arg Gln Lys Arg Asp 
        35                  40                  45              


Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Xaa Ser Leu 
    50                  55                  60                  


Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val Asp 
                85                  90                  95      


Ala Glu Xaa Gly Asp Val Phe Ala Ile Glu Arg Leu Asp Arg Glu Asn 
            100                 105                 110         


Ile Ser Glu Tyr His Leu Xaa Ala Val Ile Val Asp Lys Asp Xaa Gly 
        115                 120                 125             


Glu Asn Leu Glu Xaa Pro Ser Ser Phe Xaa Ile Lys Val His Asp Val 
    130                 135                 140                 


Asn Asp Asn Trp Pro Val Phe Xaa His Arg Leu Phe Asn Ala Ser Val 
145                 150                 155                 160 


Pro Glu Ser Ser Ala Val Gly Xaa Ser Val Ile Ser Val Xaa Ala Val 
                165                 170                 175     


Asp Ala Asp Asp Pro Xaa Val Gly Asp His Ala Ser Val Met Tyr Gln 
            180                 185                 190         


Ile Leu Lys Gly Lys Glu Tyr Phe Ala Ile Asp Asn Ser Gly Arg Ile 
        195                 200                 205             


Ile Xaa Ile Xaa Lys Ser Leu Asp Arg Glu Lys Gln Ala Arg Tyr Glu 
    210                 215                 220                 


Ile Val Val Glu Ala Arg Asp Ala Gln Gly Leu Arg Gly Asp Ser Gly 
225                 230                 235                 240 


Xaa Ala Xaa Val Leu Val Xaa Leu Gln Asp Ile Asn Asp Asn Phe Pro 
                245                 250                 255     


Phe Phe Xaa Gln Xaa Lys Tyr Xaa Phe Val Val Pro Glu Asp Xaa Arg 
            260                 265                 270         


Val Gly Xaa Ser Val Gly Ser Leu Phe Val Glu Asp Pro Asp Glu Pro 
        275                 280                 285             


Gln Asn Arg Met Xaa Lys Tyr Ser Ile Leu Arg Gly Asp Tyr Gln Asp 
    290                 295                 300                 


Ala Phe Xaa Ile Glu Xaa Asn Pro Ala His Asn Glu Gly Ile Ile Lys 
305                 310                 315                 320 


Pro Met Lys Pro Leu Asp Tyr Glu Tyr Ile Gln Gln Tyr Ser Phe Ile 
                325                 330                 335     


Val Glu Ala Xaa Asp Pro Xaa Ile Asp Leu Arg Tyr Met Ser Pro Pro 
            340                 345                 350         


Ala Gly Asn Arg Ala Gln Val Ile Ile Asn Ile Xaa Asp Val Asp Glu 
        355                 360                 365             


Pro Pro Ile Phe Gln Gln Pro Phe Tyr His Phe Gln Leu Val Leu Gln 
    370                 375                 380                 


Ile Ser Ala Ile Asp Lys Asp Ile Xaa Pro Arg Asn Val Lys Phe Lys 
385                 390                 395                 400 


Phe Ile Leu Asn Xaa Glu Asn Asn Phe Xaa Leu Xaa Asp Asn His Asp 
                405                 410                 415     


Asn Xaa Ala Asn Ile Xaa Val Lys Tyr Gly Gln Phe Asp Arg Glu His 
            420                 425                 430         


Xaa Lys Val His Phe Leu Pro Val Val Ile Ser Asp Asn Gly Met Pro 
        435                 440                 445             


Ser Arg Xaa Gly Xaa Ser Xaa Leu Xaa Val Ala Val Cys Lys Cys Asn 
    450                 455                 460                 


Glu Gln Gly Glu Phe Xaa Phe Cys Glu Asp Met Ala Ala Gln Val Gly 
465                 470                 475                 480 


Val Ser Ile Gln Ala Val Val Ala Ile Leu Leu Cys Ile Leu Xaa Ile 
                485                 490                 495     


Xaa Val Ile Xaa Leu Leu Ile Phe Leu Arg Arg Arg Leu Arg Lys Gln 
            500                 505                 510         


Ala Arg Ala His Gly Lys Ser Val Pro Glu Ile His Glu Gln Leu Val 
        515                 520                 525             


Xaa Tyr Asp Glu Glu Gly Gly Gly Glu Met Asp Xaa Xaa Ser Tyr Asp 
    530                 535                 540                 


Val Ser Val Leu Asn Ser Val Arg Arg Gly Gly Ala Lys Pro Pro Arg 
545                 550                 555                 560 


Pro Ala Leu Asp Ala Arg Pro Ser Leu Tyr Ala Gln Val Gln Lys Pro 
                565                 570                 575     


Pro Arg His Ala Pro Gly Ala His Gly Gly Pro Gly Glu Met Ala Ala 
            580                 585                 590         


Met Ile Glu Val Lys Lys Asp Glu Ala Asp His Asp Gly Asp Gly Pro 
        595                 600                 605             


Pro Tyr Asp Xaa Leu His Ile Tyr Gly Tyr Glu Gly Ser Glu Ser Ile 
    610                 615                 620                 


Ala Glu Ser Leu Ser Ser Leu Gly Xaa Asp Ser Ser Asp Ser Asp Val 
625                 630                 635                 640 


Asp Tyr Asp Phe Leu Asn Asp Trp Gly Pro Arg Phe Lys Met Leu Ala 
                645                 650                 655     


Glu Leu Tyr Gly Ser Asp Pro Arg Glu Glu Leu Leu Tyr 
            660                 665                 


<210> 5710
<211> 784
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<400> 5710
Met Gln Arg Leu Met Met Leu Leu Ala Xaa Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln 
            20                  25                  30          


Arg Asp Xaa His Ser Leu Leu Pro Xaa His Arg Arg Gln Lys Arg Asp 
        35                  40                  45              


Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Xaa Ser Leu 
    50                  55                  60                  


Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val Asp 
                85                  90                  95      


Ala Glu Xaa Gly Asp Val Phe Ala Ile Glu Arg Leu Asp Arg Glu Asn 
            100                 105                 110         


Ile Ser Glu Tyr His Leu Xaa Ala Val Ile Val Asp Lys Asp Xaa Gly 
        115                 120                 125             


Glu Asn Leu Glu Xaa Pro Ser Ser Phe Xaa Ile Lys Val His Asp Val 
    130                 135                 140                 


Asn Asp Asn Trp Pro Val Phe Xaa His Arg Leu Phe Asn Ala Ser Val 
145                 150                 155                 160 


Pro Glu Ser Ser Ala Val Gly Xaa Ser Val Ile Ser Val Xaa Ala Val 
                165                 170                 175     


Asp Ala Asp Asp Pro Xaa Val Gly Asp His Ala Ser Val Met Tyr Gln 
            180                 185                 190         


Ile Leu Lys Gly Lys Glu Tyr Phe Ala Ile Asp Asn Ser Gly Arg Ile 
        195                 200                 205             


Ile Xaa Ile Xaa Lys Ser Leu Asp Arg Glu Lys Gln Ala Arg Tyr Glu 
    210                 215                 220                 


Ile Val Val Glu Ala Arg Asp Ala Gln Gly Leu Arg Gly Asp Ser Gly 
225                 230                 235                 240 


Xaa Ala Xaa Val Leu Val Xaa Leu Gln Asp Ile Asn Asp Asn Phe Pro 
                245                 250                 255     


Phe Phe Xaa Gln Xaa Lys Tyr Xaa Phe Val Val Pro Glu Asp Xaa Arg 
            260                 265                 270         


Val Gly Xaa Ser Val Gly Ser Leu Phe Val Glu Asp Pro Asp Glu Pro 
        275                 280                 285             


Gln Asn Arg Met Xaa Lys Tyr Ser Ile Leu Arg Gly Asp Tyr Gln Asp 
    290                 295                 300                 


Ala Phe Xaa Ile Glu Xaa Asn Pro Ala His Asn Glu Gly Ile Ile Lys 
305                 310                 315                 320 


Pro Met Lys Pro Leu Asp Tyr Glu Tyr Ile Gln Gln Tyr Ser Phe Ile 
                325                 330                 335     


Val Glu Ala Xaa Asp Pro Xaa Ile Asp Leu Arg Tyr Met Ser Pro Pro 
            340                 345                 350         


Ala Gly Asn Arg Ala Gln Val Ile Ile Asn Ile Xaa Asp Val Asp Glu 
        355                 360                 365             


Pro Pro Ile Phe Gln Gln Pro Phe Tyr His Phe Gln Leu Lys Glu Asn 
    370                 375                 380                 


Gln Lys Lys Pro Leu Ile Gly Xaa Val Leu Ala Met Asp Pro Asp Ala 
385                 390                 395                 400 


Ala Arg His Ser Ile Gly Tyr Ser Ile Arg Arg Xaa Ser Asp Lys Gly 
                405                 410                 415     


Gln Phe Phe Arg Val Xaa Lys Lys Gly Asp Ile Tyr Asn Glu Lys Glu 
            420                 425                 430         


Leu Asp Arg Glu Val Tyr Pro Trp Tyr Asn Leu Xaa Val Glu Ala Lys 
        435                 440                 445             


Glu Leu Asp Ser Xaa Gly Xaa Pro Xaa Gly Lys Glu Ser Ile Val Gln 
    450                 455                 460                 


Val His Ile Glu Val Leu Asp Glu Asn Asp Asn Ala Pro Glu Phe Ala 
465                 470                 475                 480 


Lys Pro Tyr Gln Pro Lys Val Cys Glu Asn Ala Val His Gly Gln Leu 
                485                 490                 495     


Val Leu Gln Ile Ser Ala Ile Asp Lys Asp Ile Xaa Pro Arg Asn Val 
            500                 505                 510         


Lys Phe Lys Phe Ile Leu Asn Xaa Glu Asn Asn Phe Xaa Leu Xaa Asp 
        515                 520                 525             


Asn His Asp Asn Xaa Ala Asn Ile Xaa Val Lys Tyr Gly Gln Phe Asp 
    530                 535                 540                 


Arg Glu His Xaa Lys Val His Phe Leu Pro Val Val Ile Ser Asp Asn 
545                 550                 555                 560 


Gly Met Pro Ser Arg Xaa Gly Xaa Ser Xaa Leu Xaa Val Ala Val Cys 
                565                 570                 575     


Lys Cys Asn Glu Gln Gly Glu Phe Xaa Phe Cys Glu Asp Met Ala Ala 
            580                 585                 590         


Gln Val Gly Val Ser Ile Gln Ala Val Val Ala Ile Leu Leu Cys Ile 
        595                 600                 605             


Leu Xaa Ile Xaa Val Ile Xaa Leu Leu Ile Phe Leu Arg Arg Arg Leu 
    610                 615                 620                 


Arg Lys Gln Ala Arg Ala His Gly Lys Ser Val Pro Glu Ile His Glu 
625                 630                 635                 640 


Gln Leu Val Xaa Tyr Asp Glu Glu Gly Gly Gly Glu Met Asp Xaa Xaa 
                645                 650                 655     


Ser Tyr Asp Val Ser Val Leu Asn Ser Val Arg Arg Gly Gly Ala Lys 
            660                 665                 670         


Pro Pro Arg Pro Ala Leu Asp Ala Arg Pro Ser Leu Tyr Ala Gln Val 
        675                 680                 685             


Gln Lys Pro Pro Arg His Ala Pro Gly Ala His Gly Gly Pro Gly Glu 
    690                 695                 700                 


Met Ala Ala Met Ile Glu Val Lys Lys Asp Glu Ala Asp His Asp Gly 
705                 710                 715                 720 


Asp Gly Pro Pro Tyr Asp Xaa Leu His Ile Tyr Gly Tyr Glu Gly Ser 
                725                 730                 735     


Glu Ser Ile Ala Glu Ser Leu Ser Ser Leu Gly Xaa Asp Ser Ser Asp 
            740                 745                 750         


Ser Asp Val Asp Tyr Asp Phe Leu Asn Asp Trp Gly Pro Arg Phe Lys 
        755                 760                 765             


Met Leu Ala Glu Leu Tyr Gly Ser Asp Pro Arg Glu Glu Leu Leu Tyr 
    770                 775                 780                 


<210> 5711
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<400> 5711
Met Gln Arg Leu Met Met Leu Leu Ala Xaa Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln 
            20                  25                  30          


Arg Asp Xaa His Ser Leu Leu Pro Xaa His Arg Arg Gln Lys Arg Asp 
        35                  40                  45              


Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Xaa Ser Leu 
    50                  55                  60                  


Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val Asp 
                85                  90                  95      


Ala Glu Xaa Gly Asp Val Xaa Gln Met Ser Pro Arg Xaa Gly 
            100                 105                 110 


<210> 5712
<211> 790
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(758)
<223> Selenocysteine

<400> 5712
Met Arg Xaa Tyr Arg Tyr Phe Leu Leu Leu Phe Trp Val Gly Gln Pro 
1               5                   10                  15      


Tyr Pro Xaa Leu Ser Xaa Pro Leu Ser Lys Arg Xaa Ser Gly Phe Pro 
            20                  25                  30          


Ala Lys Lys Arg Ala Leu Glu Leu Ser Gly Asn Ser Lys Asn Glu Leu 
        35                  40                  45              


Asn Arg Ser Lys Arg Ser Trp Met Trp Asn Gln Phe Phe Leu Leu Glu 
    50                  55                  60                  


Glu Tyr Xaa Gly Ser Asp Tyr Gln Tyr Val Gly Lys Leu His Ser Asp 
65                  70                  75                  80  


Gln Asp Arg Gly Asp Gly Ser Leu Lys Tyr Ile Leu Ser Gly Asp Gly 
                85                  90                  95      


Ala Gly Asp Leu Phe Ile Ile Asn Glu Asn Xaa Gly Asp Ile Gln Ala 
            100                 105                 110         


Xaa Lys Arg Leu Asp Arg Glu Glu Lys Pro Val Tyr Ile Leu Arg Ala 
        115                 120                 125             


Gln Ala Ile Asn Arg Arg Xaa Gly Arg Pro Val Glu Pro Glu Ser Glu 
    130                 135                 140                 


Phe Ile Ile Lys Ile His Asp Ile Asn Asp Asn Glu Pro Ile Phe Xaa 
145                 150                 155                 160 


Lys Glu Val Tyr Xaa Ala Xaa Val Pro Glu Met Ser Asp Val Gly Xaa 
                165                 170                 175     


Phe Val Val Gln Val Xaa Ala Xaa Asp Ala Asp Asp Pro Xaa Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Glu Ser Glu Xaa Gly Ile Ile Lys Xaa Ala Leu Leu Asn Met 
    210                 215                 220                 


Asp Arg Glu Asn Arg Glu Gln Tyr Gln Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Gly Gly Gln Met Gly Gly Leu Ser Gly Xaa Xaa Xaa Val Asn Ile 
                245                 250                 255     


Xaa Leu Xaa Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Gln Ser Xaa 
            260                 265                 270         


Tyr Gln Phe Lys Xaa Pro Glu Ser Ser Pro Pro Gly Xaa Pro Ile Gly 
        275                 280                 285             


Arg Ile Lys Ala Ser Asp Ala Asp Val Gly Glu Asn Ala Glu Ile Glu 
    290                 295                 300                 


Tyr Ser Ile Xaa Asp Gly Glu Gly Leu Asp Met Phe Asp Val Ile Xaa 
305                 310                 315                 320 


Asp Gln Glu Xaa Gln Glu Gly Ile Ile Xaa Val Lys Lys Leu Leu Asp 
                325                 330                 335     


Phe Glu Lys Lys Lys Val Tyr Xaa Leu Lys Val Glu Ala Ser Asn Pro 
            340                 345                 350         


Tyr Val Glu Pro Arg Phe Leu Tyr Leu Gly Pro Phe Lys Asp Ser Ala 
        355                 360                 365             


Xaa Val Arg Ile Val Val Glu Asp Val Asp Glu Pro Pro Val Phe Ser 
    370                 375                 380                 


Lys Leu Ala Tyr Ile Leu Gln Ile Arg Glu Asp Ala Gln Ile Asn Xaa 
385                 390                 395                 400 


Xaa Ile Gly Ser Val Xaa Ala Gln Asp Pro Asp Ala Ala Arg Asn Pro 
                405                 410                 415     


Val Lys Tyr Ser Val Asp Arg His Xaa Asp Met Asp Arg Ile Phe Asn 
            420                 425                 430         


Ile Asp Ser Gly Asn Gly Ser Ile Phe Xaa Ser Lys Leu Leu Asp Arg 
        435                 440                 445             


Glu Xaa Leu Leu Trp His Asn Ile Xaa Val Ile Ala Xaa Glu Ile Asn 
    450                 455                 460                 


Asn Pro Lys Gln Ser Ser Arg Val Pro Leu Tyr Ile Lys Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Ala Pro Glu Phe Ala Glu Phe Tyr Glu Xaa Phe Val 
                485                 490                 495     


Cys Glu Lys Ala Lys Ala Asp Gln Leu Ile Gln Xaa Leu His Ala Val 
            500                 505                 510         


Asp Lys Asp Asp Pro Tyr Ser Gly His Gln Phe Ser Phe Ser Leu Ala 
        515                 520                 525             


Pro Glu Ala Ala Ser Gly Ser Asn Phe Xaa Ile Gln Asp Asn Lys Asp 
    530                 535                 540                 


Asn Xaa Ala Gly Ile Leu Xaa Arg Lys Asn Gly Tyr Asn Arg His Glu 
545                 550                 555                 560 


Met Ser Xaa Tyr Leu Leu Pro Val Val Ile Ser Asp Asn Asp Tyr Pro 
                565                 570                 575     


Val Gln Ser Ser Xaa Gly Xaa Val Xaa Val Arg Val Cys Ala Cys Asp 
            580                 585                 590         


His His Gly Asn Met Gln Ser Cys His Ala Glu Ala Leu Ile His Pro 
        595                 600                 605             


Xaa Gly Leu Ser Xaa Gly Ala Leu Val Ala Ile Leu Leu Cys Ile Val 
    610                 615                 620                 


Ile Leu Leu Val Xaa Val Val Leu Phe Ala Ala Leu Arg Arg Gln Arg 
625                 630                 635                 640 


Lys Lys Glu Pro Leu Ile Ile Ser Lys Glu Asp Ile Arg Asp Asn Ile 
                645                 650                 655     


Val Ser Tyr Asn Asp Glu Gly Gly Gly Glu Glu Asp Xaa Gln Ala Phe 
            660                 665                 670         


Asp Ile Gly Xaa Leu Arg Asn Pro Glu Ala Ile Glu Asp Asn Lys Leu 
        675                 680                 685             


Arg Arg Asp Ile Val Pro Glu Ala Leu Phe Leu Pro Arg Arg Xaa Pro 
    690                 695                 700                 


Xaa Ala Arg Asp Asn Xaa Asp Val Arg Asp Phe Ile Asn Gln Arg Leu 
705                 710                 715                 720 


Lys Glu Asn Asp Xaa Asp Pro Xaa Ala Pro Pro Tyr Asp Ser Leu Ala 
                725                 730                 735     


Xaa Tyr Ala Tyr Glu Gly Xaa Gly Ser Val Ala Asp Ser Leu Ser Ser 
            740                 745                 750         


Leu Glu Ser Val Xaa Xaa Asp Ala Asp Gln Asp Tyr Asp Tyr Leu Ser 
        755                 760                 765             


Asp Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Val 
    770                 775                 780                 


Asp Ser Asp Lys Asp Ser 
785                 790 


<210> 5713
<211> 608
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<400> 5713
Met Trp Asn Gln Phe Phe Leu Leu Glu Glu Tyr Xaa Gly Ser Asp Tyr 
1               5                   10                  15      


Gln Tyr Val Gly Lys Leu His Ser Asp Gln Asp Arg Gly Asp Gly Ser 
            20                  25                  30          


Leu Lys Tyr Ile Leu Ser Gly Asp Gly Ala Gly Asp Leu Phe Ile Ile 
        35                  40                  45              


Asn Glu Asn Xaa Gly Asp Ile Gln Ala Xaa Lys Arg Leu Asp Arg Glu 
    50                  55                  60                  


Glu Lys Pro Val Tyr Ile Leu Arg Ala Gln Ala Ile Asn Arg Arg Xaa 
65                  70                  75                  80  


Gly Arg Pro Val Glu Pro Glu Ser Glu Phe Ile Ile Lys Ile His Asp 
                85                  90                  95      


Ile Asn Asp Asn Glu Pro Ile Phe Xaa Lys Glu Val Tyr Xaa Ala Xaa 
            100                 105                 110         


Val Pro Glu Met Ser Asp Val Gly Xaa Phe Val Val Gln Val Xaa Ala 
        115                 120                 125             


Xaa Asp Ala Asp Asp Pro Xaa Tyr Gly Asn Ser Ala Lys Val Val Tyr 
    130                 135                 140                 


Ser Ile Leu Gln Gly Gln Pro Tyr Phe Ser Val Glu Ser Glu Xaa Gly 
145                 150                 155                 160 


Ile Ile Lys Xaa Ala Leu Leu Asn Met Asp Arg Glu Asn Arg Glu Gln 
                165                 170                 175     


Tyr Gln Val Val Ile Gln Ala Lys Asp Met Gly Gly Gln Met Gly Gly 
            180                 185                 190         


Leu Ser Gly Xaa Xaa Xaa Val Asn Ile Xaa Leu Xaa Asp Val Asn Asp 
        195                 200                 205             


Asn Pro Pro Arg Phe Pro Gln Ser Xaa Tyr Gln Phe Lys Xaa Pro Glu 
    210                 215                 220                 


Ser Ser Pro Pro Gly Xaa Pro Ile Gly Arg Ile Lys Ala Ser Asp Ala 
225                 230                 235                 240 


Asp Val Gly Glu Asn Ala Glu Ile Glu Tyr Ser Ile Xaa Asp Gly Glu 
                245                 250                 255     


Gly Leu Asp Met Phe Asp Val Ile Xaa Asp Gln Glu Xaa Gln Glu Gly 
            260                 265                 270         


Ile Ile Xaa Val Lys Lys Leu Leu Asp Phe Glu Lys Lys Lys Val Tyr 
        275                 280                 285             


Xaa Leu Lys Val Glu Ala Ser Asn Pro Tyr Val Glu Pro Arg Phe Leu 
    290                 295                 300                 


Tyr Leu Gly Pro Phe Lys Asp Ser Ala Xaa Val Arg Ile Val Val Glu 
305                 310                 315                 320 


Asp Val Asp Glu Pro Pro Val Phe Ser Lys Leu Ala Tyr Ile Leu Gln 
                325                 330                 335     


Ile Arg Glu Asp Ala Gln Ile Asn Xaa Xaa Ile Gly Ser Val Xaa Ala 
            340                 345                 350         


Gln Asp Pro Asp Ala Ala Arg Asn Pro Val Lys Tyr Ser Val Asp Arg 
        355                 360                 365             


His Xaa Asp Met Asp Arg Ile Phe Asn Ile Asp Ser Gly Asn Gly Ser 
    370                 375                 380                 


Ile Phe Xaa Ser Lys Leu Leu Asp Arg Glu Xaa Leu Leu Trp His Asn 
385                 390                 395                 400 


Ile Xaa Val Ile Ala Xaa Glu Ile Asn Asn Pro Lys Gln Ser Ser Arg 
                405                 410                 415     


Val Pro Leu Tyr Ile Lys Val Leu Asp Val Asn Asp Asn Ala Pro Glu 
            420                 425                 430         


Phe Ala Glu Phe Tyr Glu Xaa Phe Val Cys Glu Lys Ala Lys Ala Asp 
        435                 440                 445             


Gln Leu Ile Gln Xaa Leu His Ala Val Asp Lys Asp Asp Pro Tyr Ser 
    450                 455                 460                 


Gly His Gln Phe Ser Phe Ser Leu Ala Pro Glu Ala Ala Ser Gly Ser 
465                 470                 475                 480 


Asn Phe Xaa Ile Gln Asp Asn Lys Asp Asn Xaa Ala Gly Ile Leu Xaa 
                485                 490                 495     


Arg Lys Asn Gly Tyr Asn Arg His Glu Met Ser Xaa Tyr Leu Leu Pro 
            500                 505                 510         


Val Val Ile Ser Asp Asn Asp Tyr Pro Val Gln Ser Ser Xaa Gly Xaa 
        515                 520                 525             


Val Xaa Val Arg Val Cys Ala Cys Asp His His Gly Asn Met Gln Ser 
    530                 535                 540                 


Cys His Ala Glu Ala Leu Ile His Pro Xaa Gly Leu Ser Xaa Gly Ala 
545                 550                 555                 560 


Leu Val Ala Ile Leu Leu Cys Ile Val Ile Leu Leu Gly Lys Leu Val 
                565                 570                 575     


Leu Pro Ala Ser Tyr Leu Pro Met Val Arg Gly Ser His Cys Tyr Cys 
            580                 585                 590         


Asp Xaa Leu Asp Leu Ser Ala Ser Pro Ile Lys Ala Tyr Ser Leu Ile 
        595                 600                 605             


<210> 5714
<211> 52
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<400> 5714
Met Gln Pro Pro Pro Gly Met Pro Leu Pro Pro Ala Asp Ile Gly Pro 
1               5                   10                  15      


Pro Pro Tyr Glu Pro Pro Gly His Pro Met Pro Gln Pro Gly Phe Ile 
            20                  25                  30          


Pro Pro His Met Ser Ala Asp Gly Xaa Tyr Met Pro Pro Asp Val Ile 
        35                  40                  45              


Trp Ala Ala Ala 
    50          


<210> 5715
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<400> 5715
Met Gln Pro Pro Pro Gly Met Pro Leu Pro Pro Ala Asp Ile Gly Pro 
1               5                   10                  15      


Pro Pro Tyr Glu Pro Pro Gly His Pro Met Pro Gln Pro Gly Phe Ile 
            20                  25                  30          


Pro Pro His Met Ser Ala Asp Gly Xaa Tyr Met Pro Pro Gly Phe Tyr 
        35                  40                  45              


Pro Pro Pro Gly Pro His Pro Pro Met Gly Tyr Tyr Pro Pro Gly Pro 
    50                  55                  60                  


Tyr Xaa Pro Gly Pro Tyr Pro Gly Pro Gly Gly His Xaa Ala Xaa Val 
65                  70                  75                  80  


Leu Val Pro Ser Gly Ala Ala Xaa Xaa Val Xaa Val Leu Gln Gly 
                85                  90                  95  


<210> 5716
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<400> 5716
Met Gln Pro Pro Pro Gly Met Pro Leu Pro Pro Ala Asp Ile Gly Pro 
1               5                   10                  15      


Pro Pro Tyr Glu Pro Pro Gly His Pro Met Pro Gln Pro Gly Phe Ile 
            20                  25                  30          


Pro Pro His Met Ser Ala Asp Gly Xaa Tyr Met Pro Pro Gly Phe Tyr 
        35                  40                  45              


Pro Pro Pro Gly Pro His Pro Pro Met Gly Tyr Tyr Pro Pro Gly Pro 
    50                  55                  60                  


Tyr Xaa Pro Gly Pro Tyr Pro Gly Pro Gly Gly His Xaa Ala Xaa Val 
65                  70                  75                  80  


Leu Val Pro Ser Gly Ala Ala Xaa Xaa Val Xaa Val Leu Gln Gly Glu 
                85                  90                  95      


Ile Phe Glu Gly Ala Pro Val Gln Xaa Val Cys Pro His Cys Gln 
            100                 105                 110     


<210> 5717
<211> 89
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<400> 5717
Met Gln Pro Pro Pro Gly Met Pro Leu Pro Pro Ala Asp Ile Gly Pro 
1               5                   10                  15      


Pro Pro Tyr Glu Pro Pro Gly His Pro Met Pro Gln Pro Gly Phe Ile 
            20                  25                  30          


Pro Pro His Met Ser Ala Asp Gly Xaa Tyr Met Pro Pro Gly Pro Tyr 
        35                  40                  45              


Pro Gly Pro Gly Gly His Xaa Ala Xaa Val Leu Val Pro Ser Gly Ala 
    50                  55                  60                  


Ala Xaa Xaa Val Xaa Val Leu Gln Gly Glu Ile Phe Glu Gly Ala Pro 
65                  70                  75                  80  


Val Gln Xaa Val Cys Pro His Cys Gln 
                85                  


<210> 5718
<211> 29
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 5718
Met Ser Ser Glu Pro Pro Pro Pro Tyr Pro Gly Gly Pro Xaa Ala Pro 
1               5                   10                  15      


Leu Leu Glu Glu Lys Ser Gly Ala Pro Pro Xaa Pro Gly 
            20                  25                  


<210> 5719
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<400> 5719
Met Ser Ser Glu Pro Pro Pro Pro Tyr Pro Gly Gly Pro Xaa Ala Pro 
1               5                   10                  15      


Leu Leu Glu Glu Lys Ser Gly Ala Pro Pro Xaa Pro Gly Arg Ser Ser 
            20                  25                  30          


Pro Ala Val Met Gln Pro Pro Pro Gly Ala Ala Xaa Xaa Val Xaa Val 
        35                  40                  45              


Leu Gln Gly Glu Ile Phe Glu Gly Ala Pro Val Gln Xaa Val Cys Pro 
    50                  55                  60                  


His Cys Gln Gln Ala Ile Xaa Xaa Lys Ile Ser Tyr Glu Ile Gly Leu 
65                  70                  75                  80  


Met Asn Phe Val Leu Gly Phe Phe Cys Cys Phe Met Gly Cys Asp Leu 
                85                  90                  95      


Gly Cys Cys Leu Ile Pro Cys Leu Ile Asn Asp Phe Lys Asp Val Xaa 
            100                 105                 110         


His Xaa Cys Pro Ser Cys Lys Ala Tyr Ile Tyr Xaa Tyr Lys Arg Leu 
        115                 120                 125             


Cys 
    


<210> 5720
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 5720
Met Ser Ser Glu Pro Pro Pro Pro Tyr Pro Gly Gly Pro Xaa Ala Pro 
1               5                   10                  15      


Leu Leu Glu Glu Lys Ser Gly Ala Pro Pro Xaa Pro Gly Arg Ser Ser 
            20                  25                  30          


Pro Ala Val Met Gln Pro Pro Pro Gly Met Pro Leu Pro Pro Ala Asp 
        35                  40                  45              


Ile Gly Pro Pro Pro Tyr Glu Pro Pro Gly His Pro Met Pro Gln Pro 
    50                  55                  60                  


Gly Phe Ile Pro Pro His Met Ser Ala Asp Gly Xaa Tyr Met Pro Pro 
65                  70                  75                  80  


Ala Ala Lys Pro Xaa Ser Xaa Arg Xaa Ser Ala Cys Ala Asn Gly Ala 
                85                  90                  95      


Gly Xaa Arg Asp Ser Pro Ala Cys Gln Ser Gly Pro Leu Cys Phe Ala 
            100                 105                 110         


Pro Cys Ala Gln Trp Ser Leu Ser Arg Ser His Leu Gly Leu Gly Ala 
        115                 120                 125             


Val Pro Pro Ser Pro 
    130             


<210> 5721
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<400> 5721
Met Ser Ser Glu Pro Pro Pro Pro Tyr Pro Gly Gly Pro Xaa Ala Pro 
1               5                   10                  15      


Leu Leu Glu Glu Lys Ser Gly Ala Pro Pro Xaa Pro Gly Arg Ser Ser 
            20                  25                  30          


Pro Ala Val Met Gln Pro Pro Pro Gly Met Pro Leu Pro Pro Ala Asp 
        35                  40                  45              


Ile Gly Pro Pro Pro Tyr Glu Pro Pro Gly His Pro Met Pro Gln Pro 
    50                  55                  60                  


Gly Phe Ile Pro Pro His Met Ser Ala Asp Gly Xaa Tyr Met Pro Pro 
65                  70                  75                  80  


Gly 
    


<210> 5722
<211> 169
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<400> 5722
Met Ser Ser Glu Pro Pro Pro Pro Tyr Pro Gly Gly Pro Xaa Ala Pro 
1               5                   10                  15      


Leu Leu Glu Glu Lys Ser Gly Ala Pro Pro Xaa Pro Gly Arg Ser Ser 
            20                  25                  30          


Pro Ala Val Met Gln Pro Pro Pro Gly Met Pro Leu Pro Pro Ala Asp 
        35                  40                  45              


Ile Gly Pro Pro Pro Tyr Glu Pro Pro Gly His Pro Met Pro Gln Pro 
    50                  55                  60                  


Gly Phe Ile Pro Pro His Met Ser Ala Asp Gly Xaa Tyr Met Pro Pro 
65                  70                  75                  80  


Gly Ala Ala Xaa Xaa Val Xaa Val Leu Gln Gly Glu Ile Phe Glu Gly 
                85                  90                  95      


Ala Pro Val Gln Xaa Val Cys Pro His Cys Gln Gln Ala Ile Xaa Xaa 
            100                 105                 110         


Lys Ile Ser Tyr Glu Ile Gly Leu Met Asn Phe Val Leu Gly Phe Phe 
        115                 120                 125             


Cys Cys Phe Met Gly Cys Asp Leu Gly Cys Cys Leu Ile Pro Cys Leu 
    130                 135                 140                 


Ile Asn Asp Phe Lys Asp Val Xaa His Xaa Cys Pro Ser Cys Lys Ala 
145                 150                 155                 160 


Tyr Ile Tyr Xaa Tyr Lys Arg Leu Cys 
                165                 


<210> 5723
<211> 208
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<400> 5723
Met Ser Ser Glu Pro Pro Pro Pro Tyr Pro Gly Gly Pro Xaa Ala Pro 
1               5                   10                  15      


Leu Leu Glu Glu Lys Ser Gly Ala Pro Pro Xaa Pro Gly Arg Ser Ser 
            20                  25                  30          


Pro Ala Val Met Gln Pro Pro Pro Gly Met Pro Leu Pro Pro Ala Asp 
        35                  40                  45              


Ile Gly Pro Pro Pro Tyr Glu Pro Pro Gly His Pro Met Pro Gln Pro 
    50                  55                  60                  


Gly Phe Ile Pro Pro His Met Ser Ala Asp Gly Xaa Tyr Met Pro Pro 
65                  70                  75                  80  


Gly Phe Tyr Pro Pro Pro Gly Pro His Pro Pro Met Gly Tyr Tyr Pro 
                85                  90                  95      


Pro Gly Pro Tyr Xaa Pro Gly Pro Tyr Pro Gly Pro Gly Gly His Xaa 
            100                 105                 110         


Ala Xaa Val Leu Val Pro Ser Gly Ala Ala Xaa Xaa Val Xaa Val Leu 
        115                 120                 125             


Gln Gly Glu Ile Phe Glu Gly Ala Pro Val Gln Xaa Val Cys Pro His 
    130                 135                 140                 


Cys Gln Gln Ala Ile Xaa Xaa Lys Ile Ser Tyr Glu Ile Gly Leu Met 
145                 150                 155                 160 


Asn Phe Val Leu Gly Phe Phe Cys Cys Phe Met Gly Cys Asp Leu Gly 
                165                 170                 175     


Cys Cys Leu Ile Pro Cys Leu Ile Asn Asp Phe Lys Asp Val Xaa His 
            180                 185                 190         


Xaa Cys Pro Ser Cys Lys Ala Tyr Ile Tyr Xaa Tyr Lys Arg Leu Cys 
        195                 200                 205             


<210> 5724
<211> 152
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(134)
<223> Selenocysteine

<400> 5724
Met Ser Ser Glu Pro Pro Pro Pro Tyr Pro Gly Gly Pro Xaa Ala Pro 
1               5                   10                  15      


Leu Leu Glu Glu Lys Ser Gly Ala Pro Pro Xaa Pro Gly Arg Ser Ser 
            20                  25                  30          


Pro Ala Val Met Gln Pro Pro Pro Gly Met Pro Leu Pro Pro Ala Asp 
        35                  40                  45              


Ile Gly Pro Pro Pro Tyr Glu Pro Pro Gly His Pro Met Pro Gln Pro 
    50                  55                  60                  


Gly Phe Ile Pro Pro His Met Ser Ala Asp Gly Xaa Tyr Met Pro Pro 
65                  70                  75                  80  


Gly Pro Tyr Xaa Pro Gly Pro Tyr Pro Gly Pro Gly Gly His Xaa Ala 
                85                  90                  95      


Xaa Val Leu Val Pro Ser Gly Ala Ala Xaa Xaa Val Xaa Val Leu Gln 
            100                 105                 110         


Gly Glu Ile Phe Glu Gly Ala Pro Val Gln Xaa Val Cys Pro His Cys 
        115                 120                 125             


Gln Gln Ala Ile Xaa Xaa Lys Ile Ser Tyr Glu Ile Gly Leu Met Asn 
    130                 135                 140                 


Phe Val Leu Gly Phe Phe Cys Cys 
145                 150         


<210> 5725
<211> 297
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<400> 5725
Met Glu Asp Tyr Xaa Lys Ile Glu Lys Ile Gly Glu Gly Xaa Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Gly Arg His Lys Xaa Xaa Gly Gln Val Val Ala Met 
            20                  25                  30          


Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Xaa Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val 
    50                  55                  60                  


Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe 
65                  70                  75                  80  


Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 
                85                  90                  95      


Gly Gln Tyr Met Asp Ser Ser Leu Val Lys Ser Tyr Leu Tyr Gln Ile 
            100                 105                 110         


Leu Gln Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp 
        115                 120                 125             


Leu Lys Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Xaa Ile Lys Leu 
    130                 135                 140                 


Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr 
145                 150                 155                 160 


Xaa His Glu Ala Ile Xaa Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu 
                165                 170                 175     


Gly Ser Ala Arg Tyr Ser Xaa Pro Val Asp Ile Trp Ser Ile Gly Xaa 
            180                 185                 190         


Ile Phe Ala Glu Leu Ala Xaa Lys Lys Pro Leu Phe His Gly Asp Ser 
        195                 200                 205             


Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg Ala Leu Gly Xaa Pro Asn 
    210                 215                 220                 


Asn Glu Val Trp Pro Glu Val Glu Ser Leu Gln Asp Tyr Lys Asn Xaa 
225                 230                 235                 240 


Phe Pro Lys Trp Lys Pro Gly Ser Leu Ala Ser His Val Lys Asn Leu 
                245                 250                 255     


Asp Glu Asn Gly Leu Asp Leu Leu Ser Lys Met Leu Ile Tyr Asp Pro 
            260                 265                 270         


Ala Lys Arg Ile Ser Gly Lys Met Ala Leu Asn His Pro Tyr Phe Asn 
        275                 280                 285             


Asp Leu Asp Asn Gln Ile Lys Lys Met 
    290                 295         


<210> 5726
<211> 189
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<400> 5726
Met Glu Asp Tyr Xaa Lys Ile Glu Lys Ile Gly Glu Gly Xaa Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Gly Arg His Lys Xaa Xaa Gly Gln Val Val Ala Met 
            20                  25                  30          


Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Xaa Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val 
    50                  55                  60                  


Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe 
65                  70                  75                  80  


Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 
                85                  90                  95      


Gly Gln Tyr Met Asp Ser Ser Leu Val Lys Ser Tyr Leu Tyr Gln Ile 
            100                 105                 110         


Leu Gln Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp 
        115                 120                 125             


Leu Lys Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Xaa Ile Lys Leu 
    130                 135                 140                 


Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr 
145                 150                 155                 160 


Xaa His Glu Val Val Xaa Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu 
                165                 170                 175     


Gly Ser Ala Arg Tyr Ser Xaa Pro Val Asp Ile Trp Ser 
            180                 185                 


<210> 5727
<211> 297
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<400> 5727
Met Glu Asp Tyr Xaa Lys Ile Glu Lys Ile Gly Glu Gly Xaa Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Gly Arg His Lys Xaa Xaa Gly Gln Val Val Ala Met 
            20                  25                  30          


Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Xaa Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val 
    50                  55                  60                  


Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe 
65                  70                  75                  80  


Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 
                85                  90                  95      


Gly Gln Tyr Met Asp Ser Ser Leu Val Lys Ser Tyr Leu Tyr Gln Ile 
            100                 105                 110         


Leu Gln Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp 
        115                 120                 125             


Leu Lys Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Xaa Ile Lys Leu 
    130                 135                 140                 


Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr 
145                 150                 155                 160 


Xaa His Glu Val Val Xaa Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu 
                165                 170                 175     


Gly Ser Ala Arg Tyr Ser Xaa Pro Val Asp Ile Trp Ser Ile Gly Xaa 
            180                 185                 190         


Ile Phe Ala Glu Leu Ala Xaa Lys Lys Pro Leu Phe His Gly Asp Ser 
        195                 200                 205             


Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg Ala Leu Gly Xaa Pro Asn 
    210                 215                 220                 


Asn Glu Val Trp Pro Glu Val Glu Ser Leu Gln Asp Tyr Lys Asn Xaa 
225                 230                 235                 240 


Phe Pro Lys Trp Lys Pro Gly Ser Leu Ala Ser His Val Lys Asn Leu 
                245                 250                 255     


Asp Glu Asn Gly Leu Asp Leu Leu Ser Lys Met Leu Ile Tyr Asp Pro 
            260                 265                 270         


Ala Lys Arg Ile Ser Gly Lys Met Ala Leu Asn His Pro Tyr Phe Asn 
        275                 280                 285             


Asp Leu Asp Asn Gln Ile Lys Lys Met 
    290                 295         


<210> 5728
<211> 224
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<400> 5728
Met Glu Asp Tyr Xaa Lys Ile Glu Lys Ile Gly Glu Gly Xaa Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Gly Arg His Lys Xaa Xaa Gly Gln Val Val Ala Met 
            20                  25                  30          


Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Xaa Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val 
    50                  55                  60                  


Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe 
65                  70                  75                  80  


Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 
                85                  90                  95      


Gly Gln Tyr Met Asp Ser Ser Leu Val Lys Ser Tyr Leu Tyr Gln Ile 
            100                 105                 110         


Leu Gln Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp 
        115                 120                 125             


Leu Lys Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Xaa Ile Lys Leu 
    130                 135                 140                 


Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr 
145                 150                 155                 160 


Xaa His Glu Val Val Xaa Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu 
                165                 170                 175     


Gly Ser Ala Arg Tyr Ser Xaa Pro Val Asp Ile Trp Ser Ile Gly Xaa 
            180                 185                 190         


Ile Phe Ala Glu Leu Ala Xaa Lys Lys Pro Leu Phe His Gly Asp Ser 
        195                 200                 205             


Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg Asn Phe Phe Pro Val Phe 
    210                 215                 220                 


<210> 5729
<211> 240
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<400> 5729
Met Glu Asp Tyr Xaa Lys Ile Glu Lys Ile Gly Glu Gly Xaa Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Gly Arg His Lys Xaa Xaa Gly Gln Val Val Ala Met 
            20                  25                  30          


Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Xaa Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val 
    50                  55                  60                  


Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe 
65                  70                  75                  80  


Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 
                85                  90                  95      


Gly Gln Tyr Met Asp Ser Ser Leu Val Lys Val Val Xaa Leu Trp Tyr 
            100                 105                 110         


Arg Ser Pro Glu Val Leu Leu Gly Ser Ala Arg Tyr Ser Xaa Pro Val 
        115                 120                 125             


Asp Ile Trp Ser Ile Gly Xaa Ile Phe Ala Glu Leu Ala Xaa Lys Lys 
    130                 135                 140                 


Pro Leu Phe His Gly Asp Ser Glu Ile Asp Gln Leu Phe Arg Ile Phe 
145                 150                 155                 160 


Arg Ala Leu Gly Xaa Pro Asn Asn Glu Val Trp Pro Glu Val Glu Ser 
                165                 170                 175     


Leu Gln Asp Tyr Lys Asn Xaa Phe Pro Lys Trp Lys Pro Gly Ser Leu 
            180                 185                 190         


Ala Ser His Val Lys Asn Leu Asp Glu Asn Gly Leu Asp Leu Leu Ser 
        195                 200                 205             


Lys Met Leu Ile Tyr Asp Pro Ala Lys Arg Ile Ser Gly Lys Met Ala 
    210                 215                 220                 


Leu Asn His Pro Tyr Phe Asn Asp Leu Asp Asn Gln Ile Lys Lys Met 
225                 230                 235                 240 


<210> 5730
<211> 469
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<400> 5730
Met Cys Asp Leu Ile Glu Pro Gln Pro Ala Glu Lys Ile Gly Lys Met 
1               5                   10                  15      


Lys Lys Leu Arg Arg Xaa Leu Ser Glu Ser Phe Ser Arg Ile Ala Leu 
            20                  25                  30          


Lys Lys Asp Asp Xaa Xaa Phe Asp Glu Ile Cys Val Xaa Lys Met Ser 
        35                  40                  45              


Xaa Arg Asn Cys Gln Gly Met Asp Ser Val Ile Lys Pro Leu Asp Xaa 
    50                  55                  60                  


Ile Pro Glu Asp Lys Lys Val Arg Val Gln Arg Xaa Gln Ser Xaa Phe 
65                  70                  75                  80  


Asp Pro Phe Glu Lys Pro Ala Asn Gln Val Lys Arg Val His Ser Glu 
                85                  90                  95      


Asn Asn Ala Cys Ile Asn Phe Lys Xaa Ser Ser Xaa Gly Lys Glu Ser 
            100                 105                 110         


Pro Lys Val Arg Arg His Ser Ser Pro Ser Ser Pro Xaa Ser Pro Lys 
        115                 120                 125             


Phe Gly Lys Ala Asp Ser Tyr Glu Lys Leu Glu Lys Leu Gly Glu Gly 
    130                 135                 140                 


Ser Tyr Ala Xaa Val Tyr Lys Gly Lys Ser Lys Val Asn Gly Lys Leu 
145                 150                 155                 160 


Val Ala Leu Lys Val Ile Arg Leu Gln Glu Glu Glu Gly Xaa Pro Phe 
                165                 170                 175     


Xaa Ala Ile Arg Glu Ala Ser Leu Leu Lys Gly Leu Lys His Ala Asn 
            180                 185                 190         


Ile Val Leu Leu His Asp Ile Ile His Xaa Lys Glu Xaa Leu Xaa Leu 
        195                 200                 205             


Val Phe Glu Tyr Val His Xaa Asp Leu Cys Gln Tyr Met Asp Lys His 
    210                 215                 220                 


Pro Gly Gly Leu His Pro Asp Asn Val Lys Leu Phe Leu Phe Gln Leu 
225                 230                 235                 240 


Leu Arg Gly Leu Ser Tyr Ile His Gln Arg Tyr Ile Leu His Arg Asp 
                245                 250                 255     


Leu Lys Pro Gln Asn Leu Leu Ile Ser Asp Xaa Gly Glu Leu Lys Leu 
            260                 265                 270         


Ala Asp Phe Gly Leu Ala Arg Ala Lys Ser Val Pro Ser His Xaa Tyr 
        275                 280                 285             


Ser Asn Glu Val Val Xaa Leu Trp Tyr Arg Pro Pro Asp Val Leu Leu 
    290                 295                 300                 


Gly Ser Xaa Glu Tyr Ser Xaa Cys Leu Asp Met Trp Gly Val Gly Cys 
305                 310                 315                 320 


Ile Phe Val Glu Met Ile Gln Gly Val Ala Ala Phe Pro Gly Met Lys 
                325                 330                 335     


Asp Ile Gln Asp Gln Leu Glu Arg Ile Phe Leu Val Leu Gly Xaa Pro 
            340                 345                 350         


Asn Glu Asp Xaa Trp Pro Gly Val His Ser Leu Pro His Phe Lys Pro 
        355                 360                 365             


Glu Arg Phe Xaa Leu Tyr Ser Ser Lys Asn Leu Arg Gln Ala Trp Asn 
    370                 375                 380                 


Lys Leu Ser Tyr Val Asn His Ala Glu Asp Leu Ala Ser Lys Leu Leu 
385                 390                 395                 400 


Gln Cys Ser Pro Lys Asn Arg Leu Ser Ala Gln Ala Ala Leu Ser His 
                405                 410                 415     


Glu Tyr Phe Ser Asp Leu Pro Pro Arg Leu Trp Glu Leu Xaa Asp Met 
            420                 425                 430         


Ser Ser Ile Phe Xaa Val Pro Asn Val Arg Leu Gln Pro Glu Ala Gly 
        435                 440                 445             


Glu Ser Met Arg Ala Phe Gly Lys Asn Asn Ser Tyr Gly Lys Ser Leu 
    450                 455                 460                 


Ser Asn Ser Lys His 
465                 


<210> 5731
<211> 451
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<400> 5731
Met His Gly Tyr Phe Gly Cys Asn Ala Ala Ala Glu Pro Gly Tyr Ser 
1               5                   10                  15      


Ala Phe Val Gly Xaa Pro Gln Ile Cys Val Xaa Lys Met Ser Xaa Arg 
            20                  25                  30          


Asn Cys Gln Gly Met Asp Ser Val Ile Lys Pro Leu Asp Xaa Ile Pro 
        35                  40                  45              


Glu Asp Lys Lys Val Arg Val Gln Arg Xaa Gln Ser Xaa Phe Asp Pro 
    50                  55                  60                  


Phe Glu Lys Pro Ala Asn Gln Val Lys Arg Val His Ser Glu Asn Asn 
65                  70                  75                  80  


Ala Cys Ile Asn Phe Lys Xaa Ser Ser Xaa Gly Lys Glu Ser Pro Lys 
                85                  90                  95      


Val Arg Arg His Ser Ser Pro Ser Ser Pro Xaa Ser Pro Lys Phe Gly 
            100                 105                 110         


Lys Ala Asp Ser Tyr Glu Lys Leu Glu Lys Leu Gly Glu Gly Ser Tyr 
        115                 120                 125             


Ala Xaa Val Tyr Lys Gly Lys Ser Lys Val Asn Gly Lys Leu Val Ala 
    130                 135                 140                 


Leu Lys Val Ile Arg Leu Gln Glu Glu Glu Gly Xaa Pro Phe Xaa Ala 
145                 150                 155                 160 


Ile Arg Glu Ala Ser Leu Leu Lys Gly Leu Lys His Ala Asn Ile Val 
                165                 170                 175     


Leu Leu His Asp Ile Ile His Xaa Lys Glu Xaa Leu Xaa Leu Val Phe 
            180                 185                 190         


Glu Tyr Val His Xaa Asp Leu Cys Gln Tyr Met Asp Lys His Pro Gly 
        195                 200                 205             


Gly Leu His Pro Asp Asn Val Lys Leu Phe Leu Phe Gln Leu Leu Arg 
    210                 215                 220                 


Gly Leu Ser Tyr Ile His Gln Arg Tyr Ile Leu His Arg Asp Leu Lys 
225                 230                 235                 240 


Pro Gln Asn Leu Leu Ile Ser Asp Xaa Gly Glu Leu Lys Leu Ala Asp 
                245                 250                 255     


Phe Gly Leu Ala Arg Ala Lys Ser Val Pro Ser His Xaa Tyr Ser Asn 
            260                 265                 270         


Glu Val Val Xaa Leu Trp Tyr Arg Pro Pro Asp Val Leu Leu Gly Ser 
        275                 280                 285             


Xaa Glu Tyr Ser Xaa Cys Leu Asp Met Trp Gly Val Gly Cys Ile Phe 
    290                 295                 300                 


Val Glu Met Ile Gln Gly Val Ala Ala Phe Pro Gly Met Lys Asp Ile 
305                 310                 315                 320 


Gln Asp Gln Leu Glu Arg Ile Phe Leu Val Leu Gly Xaa Pro Asn Glu 
                325                 330                 335     


Asp Xaa Trp Pro Gly Val His Ser Leu Pro His Phe Lys Pro Glu Arg 
            340                 345                 350         


Phe Xaa Leu Tyr Ser Ser Lys Asn Leu Arg Gln Ala Trp Asn Lys Leu 
        355                 360                 365             


Ser Tyr Val Asn His Ala Glu Asp Leu Ala Ser Lys Leu Leu Gln Cys 
    370                 375                 380                 


Ser Pro Lys Asn Arg Leu Ser Ala Gln Ala Ala Leu Ser His Glu Tyr 
385                 390                 395                 400 


Phe Ser Asp Leu Pro Pro Arg Leu Trp Glu Leu Xaa Asp Met Ser Ser 
                405                 410                 415     


Ile Phe Xaa Val Pro Asn Val Arg Leu Gln Pro Glu Ala Gly Glu Ser 
            420                 425                 430         


Met Arg Ala Phe Gly Lys Asn Asn Ser Tyr Gly Lys Ser Leu Ser Asn 
        435                 440                 445             


Ser Lys His 
    450     


<210> 5732
<211> 340
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<400> 5732
Met Leu Ala Leu Xaa Leu Arg Pro Pro Pro Leu Ala Lys Ser His Leu 
1               5                   10                  15      


Lys Leu Gly Gly Xaa Pro Ala Pro Ala Arg Val Asn Gly Lys Leu Val 
            20                  25                  30          


Ala Leu Lys Val Ile Arg Leu Gln Glu Glu Glu Gly Xaa Pro Phe Xaa 
        35                  40                  45              


Ala Ile Arg Glu Ala Ser Leu Leu Lys Gly Leu Lys His Ala Asn Ile 
    50                  55                  60                  


Val Leu Leu His Asp Ile Ile His Xaa Lys Glu Xaa Leu Xaa Leu Val 
65                  70                  75                  80  


Phe Glu Tyr Val His Xaa Asp Leu Cys Gln Tyr Met Asp Lys His Pro 
                85                  90                  95      


Gly Gly Leu His Pro Asp Asn Val Lys Leu Phe Leu Phe Gln Leu Leu 
            100                 105                 110         


Arg Gly Leu Ser Tyr Ile His Gln Arg Tyr Ile Leu His Arg Asp Leu 
        115                 120                 125             


Lys Pro Gln Asn Leu Leu Ile Ser Asp Xaa Gly Glu Leu Lys Leu Ala 
    130                 135                 140                 


Asp Phe Gly Leu Ala Arg Ala Lys Ser Val Pro Ser His Xaa Tyr Ser 
145                 150                 155                 160 


Asn Glu Val Val Xaa Leu Trp Tyr Arg Pro Pro Asp Val Leu Leu Gly 
                165                 170                 175     


Ser Xaa Glu Tyr Ser Xaa Cys Leu Asp Met Trp Gly Val Gly Cys Ile 
            180                 185                 190         


Phe Val Glu Met Ile Gln Gly Val Ala Ala Phe Pro Gly Met Lys Asp 
        195                 200                 205             


Ile Gln Asp Gln Leu Glu Arg Ile Phe Leu Val Leu Gly Xaa Pro Asn 
    210                 215                 220                 


Glu Asp Xaa Trp Pro Gly Val His Ser Leu Pro His Phe Lys Pro Glu 
225                 230                 235                 240 


Arg Phe Xaa Leu Tyr Ser Ser Lys Asn Leu Arg Gln Ala Trp Asn Lys 
                245                 250                 255     


Leu Ser Tyr Val Asn His Ala Glu Asp Leu Ala Ser Lys Leu Leu Gln 
            260                 265                 270         


Cys Ser Pro Lys Asn Arg Leu Ser Ala Gln Ala Ala Leu Ser His Glu 
        275                 280                 285             


Tyr Phe Ser Asp Leu Pro Pro Arg Leu Trp Glu Leu Xaa Asp Met Ser 
    290                 295                 300                 


Ser Ile Phe Xaa Val Pro Asn Val Arg Leu Gln Pro Glu Ala Gly Glu 
305                 310                 315                 320 


Ser Met Arg Ala Phe Gly Lys Asn Asn Ser Tyr Gly Lys Ser Leu Ser 
                325                 330                 335     


Asn Ser Lys His 
            340 


<210> 5733
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<400> 5733
Met Ser Xaa Arg Asn Cys Gln Gly Met Asp Ser Val Ile Lys Pro Leu 
1               5                   10                  15      


Asp Xaa Ile Pro Glu Asp Lys Lys Val Arg Val Gln Arg Xaa Gln Ser 
            20                  25                  30          


Xaa Phe Asp Pro Phe Glu Lys Pro Ala Asn Gln Val Lys Arg Val His 
        35                  40                  45              


Ser Glu Asn Asn Ala Cys Ile Asn Phe Lys Xaa Ser Ser Xaa Gly Lys 
    50                  55                  60                  


Glu Ser Pro Lys Val Arg Arg His Ser Ser Pro Ser Ser Gly Lys Trp 
65                  70                  75                  80  


Glu Val Gly Ser Ser Glu Gly Asp Gln Ala Ala Gly Arg Arg Arg Asp 
                85                  90                  95      


Xaa Phe His Ser Tyr Gln Gly Ser Phe Ser Phe Lys Arg Xaa Lys Xaa 
            100                 105                 110         


Cys 
    


<210> 5734
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<400> 5734
Met Ser Xaa Arg Asn Cys Gln Gly Met Asp Ser Val Ile Lys Pro Leu 
1               5                   10                  15      


Asp Xaa Ile Pro Glu Asp Lys Lys Val Arg Val Gln Arg Xaa Gln Ser 
            20                  25                  30          


Xaa Phe Asp Pro Phe Glu Lys Pro Ala Asn Gln Val Lys Arg Val His 
        35                  40                  45              


Ser Glu Asn Asn Ala Cys Ile Asn Phe Lys Xaa Ser Ser Xaa Gly Lys 
    50                  55                  60                  


Glu Ser Pro Lys Val Arg Arg His Ser Ser Pro Ser Ser Pro Xaa Ser 
65                  70                  75                  80  


Pro Lys Phe Gly Lys Ala Asp Ser Tyr Glu Lys Leu 
                85                  90          


<210> 5735
<211> 127
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<400> 5735
Met Ser Xaa Arg Asn Cys Gln Gly Met Asp Ser Val Ile Lys Pro Leu 
1               5                   10                  15      


Asp Xaa Ile Pro Glu Asp Lys Lys Val Arg Val Gln Arg Xaa Gln Ser 
            20                  25                  30          


Xaa Phe Asp Pro Phe Glu Lys Pro Ala Asn Gln Val Lys Arg Val His 
        35                  40                  45              


Ser Glu Asn Asn Ala Cys Ile Asn Phe Lys Xaa Ser Ser Xaa Gly Lys 
    50                  55                  60                  


Glu Ser Pro Lys Val Arg Arg His Ser Ser Pro Ser Ser Pro Xaa Ser 
65                  70                  75                  80  


Pro Lys Phe Gly Lys Ala Asp Ser Tyr Glu Lys Leu Glu Lys Leu Gly 
                85                  90                  95      


Glu Gly Ser Tyr Ala Xaa Val Tyr Lys Gly Lys Ser Lys Val Asn Gly 
            100                 105                 110         


Lys Leu Val Ala Leu Lys Val Ile Arg Leu Gln Glu Glu Glu Gly 
        115                 120                 125         


<210> 5736
<211> 423
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<400> 5736
Met Ser Xaa Arg Asn Cys Gln Gly Met Asp Ser Val Ile Lys Pro Leu 
1               5                   10                  15      


Asp Xaa Ile Pro Glu Asp Lys Lys Val Arg Val Gln Arg Xaa Gln Ser 
            20                  25                  30          


Xaa Phe Asp Pro Phe Glu Lys Pro Ala Asn Gln Val Lys Arg Val His 
        35                  40                  45              


Ser Glu Asn Asn Ala Cys Ile Asn Phe Lys Xaa Ser Ser Xaa Gly Lys 
    50                  55                  60                  


Glu Ser Pro Lys Val Arg Arg His Ser Ser Pro Ser Ser Pro Xaa Ser 
65                  70                  75                  80  


Pro Lys Phe Gly Lys Ala Asp Ser Tyr Glu Lys Leu Glu Lys Leu Gly 
                85                  90                  95      


Glu Gly Ser Tyr Ala Xaa Val Tyr Lys Gly Lys Ser Lys Val Asn Gly 
            100                 105                 110         


Lys Leu Val Ala Leu Lys Val Ile Arg Leu Gln Glu Glu Glu Gly Xaa 
        115                 120                 125             


Pro Phe Xaa Ala Ile Arg Glu Ala Ser Leu Leu Lys Gly Leu Lys His 
    130                 135                 140                 


Ala Asn Ile Val Leu Leu His Asp Ile Ile His Xaa Lys Glu Xaa Leu 
145                 150                 155                 160 


Xaa Leu Val Phe Glu Tyr Val His Xaa Asp Leu Cys Gln Tyr Met Asp 
                165                 170                 175     


Lys His Pro Gly Gly Leu His Pro Asp Asn Val Lys Leu Phe Leu Phe 
            180                 185                 190         


Gln Leu Leu Arg Gly Leu Ser Tyr Ile His Gln Arg Tyr Ile Leu His 
        195                 200                 205             


Arg Asp Leu Lys Pro Gln Asn Leu Leu Ile Ser Asp Xaa Gly Glu Leu 
    210                 215                 220                 


Lys Leu Ala Asp Phe Gly Leu Ala Arg Ala Lys Ser Val Pro Ser His 
225                 230                 235                 240 


Xaa Tyr Ser Asn Glu Val Val Xaa Leu Trp Tyr Arg Pro Pro Asp Val 
                245                 250                 255     


Leu Leu Gly Ser Xaa Glu Tyr Ser Xaa Cys Leu Asp Met Trp Gly Val 
            260                 265                 270         


Gly Cys Ile Phe Val Glu Met Ile Gln Gly Val Ala Ala Phe Pro Gly 
        275                 280                 285             


Met Lys Asp Ile Gln Asp Gln Leu Glu Arg Ile Phe Leu Val Leu Gly 
    290                 295                 300                 


Xaa Pro Asn Glu Asp Xaa Trp Pro Gly Val His Ser Leu Pro His Phe 
305                 310                 315                 320 


Lys Pro Glu Arg Phe Xaa Leu Tyr Ser Ser Lys Asn Leu Arg Gln Ala 
                325                 330                 335     


Trp Asn Lys Leu Ser Tyr Val Asn His Ala Glu Asp Leu Ala Ser Lys 
            340                 345                 350         


Leu Leu Gln Cys Ser Pro Lys Asn Arg Leu Ser Ala Gln Ala Ala Leu 
        355                 360                 365             


Ser His Glu Tyr Phe Ser Asp Leu Pro Pro Arg Leu Trp Glu Leu Xaa 
    370                 375                 380                 


Asp Met Ser Ser Ile Phe Xaa Val Pro Asn Val Arg Leu Gln Pro Glu 
385                 390                 395                 400 


Ala Gly Glu Ser Met Arg Ala Phe Gly Lys Asn Asn Ser Tyr Gly Lys 
                405                 410                 415     


Ser Leu Ser Asn Ser Lys His 
            420             


<210> 5737
<211> 39
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<400> 5737
Met Glu Asn Phe Gln Lys Val Glu Lys Ile Gly Glu Gly Xaa Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Ala Arg Asn Lys Leu Xaa Gly Glu Val Val Ala Leu 
            20                  25                  30          


Lys Lys Ile Arg Leu Asp Xaa 
        35                  


<210> 5738
<211> 264
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<400> 5738
Met Glu Asn Phe Gln Lys Val Glu Lys Ile Gly Glu Gly Xaa Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Ala Arg Asn Lys Leu Xaa Gly Glu Val Val Ala Leu 
            20                  25                  30          


Lys Lys Ile Arg Leu Asp Xaa Glu Xaa Glu Gly Val Pro Ser Xaa Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Asn His Pro Asn Ile Val 
    50                  55                  60                  


Lys Leu Leu Asp Val Ile His Xaa Glu Asn Lys Leu Tyr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Leu His Gln Asp Leu Lys Lys Phe Met Asp Ala Ser Ala Leu 
                85                  90                  95      


Xaa Gly Ile Pro Leu Pro Leu Ile Lys Ser Tyr Leu Phe Gln Leu Leu 
            100                 105                 110         


Gln Gly Leu Ala Phe Cys His Ser His Arg Val Leu His Arg Asp Leu 
        115                 120                 125             


Lys Pro Gln Asn Leu Leu Ile Asn Xaa Glu Gly Ala Ile Lys Leu Ala 
    130                 135                 140                 


Asp Phe Gly Leu Ala Arg Ala Phe Gly Val Pro Val Arg Xaa Tyr Xaa 
145                 150                 155                 160 


His Glu Val Xaa Arg Arg Ala Leu Phe Pro Gly Asp Ser Glu Ile Asp 
                165                 170                 175     


Gln Leu Phe Arg Ile Phe Arg Xaa Leu Gly Xaa Pro Asp Glu Val Val 
            180                 185                 190         


Trp Pro Gly Val Xaa Ser Met Pro Asp Tyr Lys Pro Ser Phe Pro Lys 
        195                 200                 205             


Trp Ala Arg Gln Asp Phe Ser Lys Val Val Pro Pro Leu Asp Glu Asp 
    210                 215                 220                 


Gly Arg Ser Leu Leu Ser Gln Met Leu His Tyr Asp Pro Asn Lys Arg 
225                 230                 235                 240 


Ile Ser Ala Lys Ala Ala Leu Ala His Pro Phe Phe Gln Asp Val Xaa 
                245                 250                 255     


Lys Pro Val Pro His Leu Arg Leu 
            260                 


<210> 5739
<211> 346
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<400> 5739
Met Glu Asn Phe Gln Lys Val Glu Lys Ile Gly Glu Gly Xaa Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Ala Arg Asn Lys Leu Xaa Gly Glu Val Val Ala Leu 
            20                  25                  30          


Lys Lys Ile Arg Leu Asp Xaa Glu Xaa Glu Gly Val Pro Ser Xaa Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Asn His Pro Asn Ile Val 
    50                  55                  60                  


Lys Leu Leu Asp Val Ile His Xaa Glu Asn Lys Leu Tyr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Leu His Gln Asp Leu Lys Lys Phe Met Asp Ala Ser Ala Leu 
                85                  90                  95      


Xaa Gly Ile Pro Leu Pro Leu Ile Lys Ser Tyr Leu Phe Gln Leu Leu 
            100                 105                 110         


Gln Gly Leu Ala Phe Cys His Ser His Arg Val Leu His Arg Asp Leu 
        115                 120                 125             


Lys Pro Gln Asn Leu Leu Ile Asn Xaa Glu Gly Ala Ile Lys Leu Ala 
    130                 135                 140                 


Asp Phe Gly Leu Ala Arg Ala Phe Gly Val Pro Val Arg Xaa Tyr Xaa 
145                 150                 155                 160 


His Glu Val Val Xaa Leu Trp Tyr Arg Ala Pro Glu Ile Leu Leu Gly 
                165                 170                 175     


Cys Lys Tyr Tyr Ser Xaa Ala Val Asp Ile Trp Ser Leu Gly Cys Ile 
            180                 185                 190         


Phe Ala Glu Met His Leu Val Gly Xaa Gln His His Ala Arg Cys Cys 
        195                 200                 205             


Gly Glu His Arg Arg Asn Gly Arg Gln Ser Leu Cys Pro Leu Cys Ser 
    210                 215                 220                 


Tyr Leu Glu Val Ala Ala Ser Gln Gly Trp Gly Met Xaa Ala Val Ser 
225                 230                 235                 240 


Xaa Pro Tyr Pro Val Xaa Arg Arg Ala Leu Phe Pro Gly Asp Ser Glu 
                245                 250                 255     


Ile Asp Gln Leu Phe Arg Ile Phe Arg Xaa Leu Gly Xaa Pro Asp Glu 
            260                 265                 270         


Val Val Trp Pro Gly Val Xaa Ser Met Pro Asp Tyr Lys Pro Ser Phe 
        275                 280                 285             


Pro Lys Trp Ala Arg Gln Asp Phe Ser Lys Val Val Pro Pro Leu Asp 
    290                 295                 300                 


Glu Asp Gly Arg Ser Leu Leu Ser Gln Met Leu His Tyr Asp Pro Asn 
305                 310                 315                 320 


Lys Arg Ile Ser Ala Lys Ala Ala Leu Ala His Pro Phe Phe Gln Asp 
                325                 330                 335     


Val Xaa Lys Pro Val Pro His Leu Arg Leu 
            340                 345     


<210> 5740
<211> 298
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<400> 5740
Met Glu Asn Phe Gln Lys Val Glu Lys Ile Gly Glu Gly Xaa Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Ala Arg Asn Lys Leu Xaa Gly Glu Val Val Ala Leu 
            20                  25                  30          


Lys Lys Ile Arg Leu Asp Xaa Glu Xaa Glu Gly Val Pro Ser Xaa Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Asn His Pro Asn Ile Val 
    50                  55                  60                  


Lys Leu Leu Asp Val Ile His Xaa Glu Asn Lys Leu Tyr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Leu His Gln Asp Leu Lys Lys Phe Met Asp Ala Ser Ala Leu 
                85                  90                  95      


Xaa Gly Ile Pro Leu Pro Leu Ile Lys Ser Tyr Leu Phe Gln Leu Leu 
            100                 105                 110         


Gln Gly Leu Ala Phe Cys His Ser His Arg Val Leu His Arg Asp Leu 
        115                 120                 125             


Lys Pro Gln Asn Leu Leu Ile Asn Xaa Glu Gly Ala Ile Lys Leu Ala 
    130                 135                 140                 


Asp Phe Gly Leu Ala Arg Ala Phe Gly Val Pro Val Arg Xaa Tyr Xaa 
145                 150                 155                 160 


His Glu Val Val Xaa Leu Trp Tyr Arg Ala Pro Glu Ile Leu Leu Gly 
                165                 170                 175     


Cys Lys Tyr Tyr Ser Xaa Ala Val Asp Ile Trp Ser Leu Gly Cys Ile 
            180                 185                 190         


Phe Ala Glu Met Val Xaa Arg Arg Ala Leu Phe Pro Gly Asp Ser Glu 
        195                 200                 205             


Ile Asp Gln Leu Phe Arg Ile Phe Arg Xaa Leu Gly Xaa Pro Asp Glu 
    210                 215                 220                 


Val Val Trp Pro Gly Val Xaa Ser Met Pro Asp Tyr Lys Pro Ser Phe 
225                 230                 235                 240 


Pro Lys Trp Ala Arg Gln Asp Phe Ser Lys Val Val Pro Pro Leu Asp 
                245                 250                 255     


Glu Asp Gly Arg Ser Leu Leu Ser Gln Met Leu His Tyr Asp Pro Asn 
            260                 265                 270         


Lys Arg Ile Ser Ala Lys Ala Ala Leu Ala His Pro Phe Phe Gln Asp 
        275                 280                 285             


Val Xaa Lys Pro Val Pro His Leu Arg Leu 
    290                 295             


<210> 5741
<211> 238
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<400> 5741
Met Glu Asn Phe Gln Lys Val Glu Lys Ile Gly Glu Gly Xaa Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Ala Arg Asn Lys Leu Xaa Gly Glu Val Val Ala Leu 
            20                  25                  30          


Lys Lys Ile Arg Leu Asp Xaa Leu Leu Asp Val Ile His Xaa Glu Asn 
        35                  40                  45              


Lys Leu Tyr Leu Val Phe Glu Phe Leu His Gln Asp Leu Lys Lys Phe 
    50                  55                  60                  


Met Asp Ala Ser Ala Leu Xaa Gly Ile Pro Leu Pro Leu Ile Lys Ser 
65                  70                  75                  80  


Tyr Leu Phe Gln Leu Leu Gln Gly Leu Ala Phe Cys His Ser His Arg 
                85                  90                  95      


Val Leu His Arg Asp Leu Lys Pro Gln Asn Leu Leu Ile Asn Xaa Glu 
            100                 105                 110         


Gly Ala Ile Lys Leu Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Val 
        115                 120                 125             


Pro Val Arg Xaa Tyr Xaa His Glu Val Xaa Arg Arg Ala Leu Phe Pro 
    130                 135                 140                 


Gly Asp Ser Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg Xaa Leu Gly 
145                 150                 155                 160 


Xaa Pro Asp Glu Val Val Trp Pro Gly Val Xaa Ser Met Pro Asp Tyr 
                165                 170                 175     


Lys Pro Ser Phe Pro Lys Trp Ala Arg Gln Asp Phe Ser Lys Val Val 
            180                 185                 190         


Pro Pro Leu Asp Glu Asp Gly Arg Ser Leu Leu Ser Gln Met Leu His 
        195                 200                 205             


Tyr Asp Pro Asn Lys Arg Ile Ser Ala Lys Ala Ala Leu Ala His Pro 
    210                 215                 220                 


Phe Phe Gln Asp Val Xaa Lys Pro Val Pro His Leu Arg Leu 
225                 230                 235             


<210> 5742
<211> 74
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 5742
Met Ala Xaa Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Xaa Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Leu Pro Ile Ser Xaa Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Ile 
65                  70                  


<210> 5743
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 5743
Met Ala Xaa Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Xaa Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Leu Pro Ile Ser Xaa Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Xaa 
65                  70                  75                  80  


Ser Arg Xaa Asp Arg Glu Ile Lys Arg Cys Phe Val Glu Ser Leu Ser 
                85                  90                  95      


Ser Val Glu Xaa Leu Lys Pro Xaa Ser Trp Ala Lys Ser Leu Xaa 
            100                 105                 110     


<210> 5744
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<400> 5744
Met Ala Xaa Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Xaa Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Leu Pro Ile Ser Xaa Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Xaa 
65                  70                  75                  80  


Ser Arg Xaa Asp Arg Glu Ile Lys Val Xaa Leu Val Phe Glu His Val 
                85                  90                  95      


Asp Gln Asp Leu Arg Xaa Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 
            100                 105                 110         


Pro Ala Glu 
        115 


<210> 5745
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<400> 5745
Met Ala Xaa Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Xaa Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Leu Pro Ile Ser Xaa Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Xaa 
65                  70                  75                  80  


Ser Arg Xaa Asp Arg Glu Ile Lys Val Xaa Leu Val Phe Glu His Val 
                85                  90                  95      


Asp Gln Asp Leu Arg Xaa Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 
            100                 105                 110         


Pro Ala Glu Xaa Ile Lys Asp Leu Met Arg Gln Phe Leu Arg Gly Leu 
        115                 120                 125             


Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 
    130                 135                 140                 


Asn Ile Leu Val Xaa Ser Gly Gly Xaa Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala 
                165                 170 


<210> 5746
<211> 201
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<400> 5746
Met Ala Xaa Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Xaa Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Leu Pro Ile Ser Xaa Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Xaa 
65                  70                  75                  80  


Ser Arg Xaa Asp Arg Glu Ile Lys Val Xaa Leu Val Phe Glu His Val 
                85                  90                  95      


Asp Gln Asp Leu Arg Xaa Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 
            100                 105                 110         


Pro Ala Glu Xaa Ile Lys Asp Leu Met Arg Gln Phe Leu Arg Gly Leu 
        115                 120                 125             


Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 
    130                 135                 140                 


Asn Ile Leu Val Xaa Ser Gly Gly Xaa Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala Leu Xaa Pro Val Xaa Arg 
                165                 170                 175     


Ala Cys Cys Val Ala Gln Ala Gly Leu Gln Trp His Asp His Ser Ser 
            180                 185                 190         


Leu Gln Leu Gln Pro Pro Gly Leu Lys 
        195                 200     


<210> 5747
<211> 203
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<400> 5747
Met Ala Xaa Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Xaa Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Leu Pro Ile Ser Xaa Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Xaa 
65                  70                  75                  80  


Ser Arg Xaa Asp Arg Glu Ile Lys Val Xaa Leu Val Phe Glu His Val 
                85                  90                  95      


Asp Gln Asp Leu Arg Xaa Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 
            100                 105                 110         


Pro Ala Glu Xaa Ile Lys Asp Leu Met Arg Gln Phe Leu Arg Gly Leu 
        115                 120                 125             


Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 
    130                 135                 140                 


Asn Ile Leu Val Xaa Ser Gly Gly Xaa Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala Leu Xaa Pro Val Val Val 
                165                 170                 175     


Xaa Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu Gln Ser Xaa Tyr Ala 
            180                 185                 190         


Xaa Pro Val Asp Met Trp Ser Val Gly Cys Ile 
        195                 200             


<210> 5748
<211> 303
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<400> 5748
Met Ala Xaa Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Xaa Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Leu Pro Ile Ser Xaa Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Xaa 
65                  70                  75                  80  


Ser Arg Xaa Asp Arg Glu Ile Lys Val Xaa Leu Val Phe Glu His Val 
                85                  90                  95      


Asp Gln Asp Leu Arg Xaa Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 
            100                 105                 110         


Pro Ala Glu Xaa Ile Lys Asp Leu Met Arg Gln Phe Leu Arg Gly Leu 
        115                 120                 125             


Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 
    130                 135                 140                 


Asn Ile Leu Val Xaa Ser Gly Gly Xaa Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala Leu Xaa Pro Val Val Val 
                165                 170                 175     


Xaa Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu Gln Ser Xaa Tyr Ala 
            180                 185                 190         


Xaa Pro Val Asp Met Trp Ser Val Gly Cys Ile Phe Ala Glu Met Phe 
        195                 200                 205             


Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser Glu Ala Asp Gln Leu Gly 
    210                 215                 220                 


Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro Glu Asp Asp Trp Pro Arg 
225                 230                 235                 240 


Asp Val Ser Leu Pro Arg Gly Ala Phe Pro Pro Arg Gly Pro Arg Pro 
                245                 250                 255     


Val Gln Ser Val Val Pro Glu Met Glu Glu Ser Gly Ala Gln Leu Leu 
            260                 265                 270         


Leu Glu Met Leu Xaa Phe Asn Pro His Lys Arg Ile Ser Ala Phe Arg 
        275                 280                 285             


Ala Leu Gln His Ser Tyr Leu His Lys Asp Glu Gly Asn Pro Glu 
    290                 295                 300             


<210> 5749
<211> 132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<400> 5749
Met Asp Val Cys Ala Xaa Ser Arg Xaa Asp Arg Glu Ile Lys Val Xaa 
1               5                   10                  15      


Leu Val Phe Glu His Val Asp Gln Asp Leu Arg Xaa Tyr Leu Asp Lys 
            20                  25                  30          


Ala Pro Pro Pro Gly Leu Pro Ala Glu Xaa Ile Lys Asp Leu Met Arg 
        35                  40                  45              


Gln Phe Leu Arg Gly Leu Asp Phe Leu His Ala Asn Cys Ile Val His 
    50                  55                  60                  


Arg Asp Leu Lys Pro Glu Asn Ile Leu Val Xaa Ser Gly Gly Xaa Val 
65                  70                  75                  80  


Lys Leu Ala Asp Phe Gly Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala 
                85                  90                  95      


Leu Xaa Pro Val Val Val Xaa Leu Trp Tyr Arg Ala Pro Glu Val Leu 
            100                 105                 110         


Leu Gln Ser Xaa Tyr Ala Xaa Pro Val Asp Met Trp Ser Val Gly Cys 
        115                 120                 125             


Ile Phe Ala Glu 
    130         


<210> 5750
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<400> 5750
Met Asp Val Cys Ala Xaa Ser Arg Xaa Asp Arg Glu Ile Lys Val Xaa 
1               5                   10                  15      


Leu Val Phe Glu His Val Asp Gln Asp Leu Arg Xaa Tyr Leu Asp Lys 
            20                  25                  30          


Ala Pro Pro Pro Gly Leu Pro Ala Glu Xaa Ile Lys Asp Leu Met Arg 
        35                  40                  45              


Gln Phe Leu Arg Gly Leu Asp Phe Leu His Ala Asn Cys Ile Val His 
    50                  55                  60                  


Arg Asp Leu Lys Pro Glu Asn Ile Leu Val Xaa Ser Gly Gly Xaa Val 
65                  70                  75                  80  


Lys Leu Ala Asp Phe Gly Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala 
                85                  90                  95      


Leu Xaa Pro Val Val Val Xaa Leu Trp Tyr Arg Ala Pro Glu Val Leu 
            100                 105                 110         


Leu Gln Ser Xaa Tyr Ala Xaa Pro Val Asp Met Trp Ser Val Gly Cys 
        115                 120                 125             


Ile Phe Ala Glu Met Phe Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser 
    130                 135                 140                 


Glu Ala Asp Gln Leu Gly Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Asp Asp Trp Pro Arg Asp Val Ser Leu Pro Arg Gly Ala Phe Pro 
                165                 170                 175     


Pro Arg Gly Pro Arg Pro Val Gln Ser Val 
            180                 185     


<210> 5751
<211> 208
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<400> 5751
Met Asp Val Cys Ala Xaa Ser Arg Xaa Asp Arg Glu Ile Lys Val Xaa 
1               5                   10                  15      


Leu Val Phe Glu His Val Asp Gln Asp Leu Arg Xaa Tyr Leu Asp Lys 
            20                  25                  30          


Ala Pro Pro Pro Gly Leu Pro Ala Glu Xaa Ile Lys Asp Leu Met Arg 
        35                  40                  45              


Gln Phe Leu Arg Gly Leu Asp Phe Leu His Ala Asn Cys Ile Val His 
    50                  55                  60                  


Arg Asp Leu Lys Pro Glu Asn Ile Leu Val Xaa Ser Gly Gly Xaa Val 
65                  70                  75                  80  


Lys Leu Ala Asp Phe Gly Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala 
                85                  90                  95      


Leu Xaa Pro Val Val Val Xaa Leu Trp Tyr Arg Ala Pro Glu Val Leu 
            100                 105                 110         


Leu Gln Ser Xaa Tyr Ala Xaa Pro Val Asp Met Trp Ser Val Gly Cys 
        115                 120                 125             


Ile Phe Ala Glu Met Phe Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser 
    130                 135                 140                 


Glu Ala Asp Gln Leu Gly Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Asp Asp Trp Pro Arg Asp Val Ser Leu Pro Arg Gly Ala Phe Pro 
                165                 170                 175     


Pro Arg Gly Pro Arg Pro Val Gln Ser Val Val Pro Glu Met Glu Glu 
            180                 185                 190         


Ser Gly Ala Gln Leu Leu Leu Glu Met Leu Xaa Phe Asn Pro His Lys 
        195                 200                 205             


<210> 5752
<211> 40
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<400> 5752
Met Glu Glu Ser Gly Ala Gln Leu Leu Leu Glu Met Leu Xaa Phe Asn 
1               5                   10                  15      


Pro His Lys Arg Ile Ser Ala Phe Arg Ala Leu Gln His Ser Tyr Leu 
            20                  25                  30          


His Lys Asp Glu Gly Asn Pro Glu 
        35                  40  


<210> 5753
<211> 260
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<400> 5753
Met Gln Lys Tyr Glu Lys Leu Glu Lys Ile Gly Glu Gly Xaa Tyr Gly 
1               5                   10                  15      


Xaa Val Phe Lys Ala Lys Asn Arg Glu Xaa His Glu Ile Val Ala Leu 
            20                  25                  30          


Lys Arg Val Arg Leu Asp Asp Asp Asp Glu Gly Val Pro Ser Ser Ala 
        35                  40                  45              


Leu Arg Glu Ile Cys Leu Leu Lys Glu Leu Lys His Lys Asn Ile Val 
    50                  55                  60                  


Arg Leu His Asp Val Leu His Ser Asp Lys Lys Leu Xaa Leu Val Phe 
65                  70                  75                  80  


Glu Phe Cys Asp Gln Asp Leu Lys Lys Tyr Phe Asp Ser Cys Asn Gly 
                85                  90                  95      


Asp Leu Asp Pro Glu Ile Val Lys Asn Gly Glu Leu Lys Leu Ala Asp 
            100                 105                 110         


Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Val Arg Cys Tyr Ser Ala 
        115                 120                 125             


Glu Val Val Xaa Leu Trp Tyr Arg Pro Pro Asp Val Leu Phe Gly Ala 
    130                 135                 140                 


Lys Leu Tyr Ser Xaa Ser Ile Asp Met Trp Ser Ala Gly Cys Ile Phe 
145                 150                 155                 160 


Ala Glu Leu Ala Asn Ala Gly Arg Pro Leu Phe Pro Gly Asn Asp Val 
                165                 170                 175     


Asp Asp Gln Leu Lys Arg Ile Phe Arg Leu Leu Gly Xaa Pro Xaa Glu 
            180                 185                 190         


Glu Gln Trp Pro Ser Met Xaa Lys Leu Pro Asp Tyr Lys Pro Tyr Pro 
        195                 200                 205             


Met Tyr Pro Ala Xaa Xaa Ser Leu Val Asn Val Val Pro Lys Leu Asn 
    210                 215                 220                 


Ala Xaa Gly Arg Asp Leu Leu Gln Asn Leu Leu Lys Cys Asn Pro Val 
225                 230                 235                 240 


Gln Arg Ile Ser Ala Glu Glu Ala Leu Gln His Pro Tyr Phe Ser Asp 
                245                 250                 255     


Phe Cys Pro Pro 
            260 


<210> 5754
<211> 292
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<400> 5754
Met Gln Lys Tyr Glu Lys Leu Glu Lys Ile Gly Glu Gly Xaa Tyr Gly 
1               5                   10                  15      


Xaa Val Phe Lys Ala Lys Asn Arg Glu Xaa His Glu Ile Val Ala Leu 
            20                  25                  30          


Lys Arg Val Arg Leu Asp Asp Asp Asp Glu Gly Val Pro Ser Ser Ala 
        35                  40                  45              


Leu Arg Glu Ile Cys Leu Leu Lys Glu Leu Lys His Lys Asn Ile Val 
    50                  55                  60                  


Arg Leu His Asp Val Leu His Ser Asp Lys Lys Leu Xaa Leu Val Phe 
65                  70                  75                  80  


Glu Phe Cys Asp Gln Asp Leu Lys Lys Tyr Phe Asp Ser Cys Asn Gly 
                85                  90                  95      


Asp Leu Asp Pro Glu Ile Val Lys Ser Phe Leu Phe Gln Leu Leu Lys 
            100                 105                 110         


Gly Leu Gly Phe Cys His Ser Arg Asn Val Leu His Arg Asp Leu Lys 
        115                 120                 125             


Pro Gln Asn Leu Leu Ile Asn Arg Asn Gly Glu Leu Lys Leu Ala Asp 
    130                 135                 140                 


Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Val Arg Cys Tyr Ser Ala 
145                 150                 155                 160 


Glu Val Val Xaa Leu Trp Tyr Arg Pro Pro Asp Val Leu Phe Gly Ala 
                165                 170                 175     


Lys Leu Tyr Ser Xaa Ser Ile Asp Met Trp Ser Ala Gly Cys Ile Phe 
            180                 185                 190         


Ala Glu Leu Ala Asn Ala Gly Arg Pro Leu Phe Pro Gly Asn Asp Val 
        195                 200                 205             


Asp Asp Gln Leu Lys Arg Ile Phe Arg Leu Leu Gly Xaa Pro Xaa Glu 
    210                 215                 220                 


Glu Gln Trp Pro Ser Met Xaa Lys Leu Pro Asp Tyr Lys Pro Tyr Pro 
225                 230                 235                 240 


Met Tyr Pro Ala Xaa Xaa Ser Leu Val Asn Val Val Pro Lys Leu Asn 
                245                 250                 255     


Ala Xaa Gly Arg Asp Leu Leu Gln Asn Leu Leu Lys Cys Asn Pro Val 
            260                 265                 270         


Gln Arg Ile Ser Ala Glu Glu Ala Leu Gln His Pro Tyr Phe Ser Asp 
        275                 280                 285             


Phe Cys Pro Pro 
    290         


<210> 5755
<211> 307
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<400> 5755
Met Gly Xaa Val Leu Ser Leu Ser Pro Ser Tyr Arg Lys Ala Xaa Leu 
1               5                   10                  15      


Phe Glu Asp Gly Ala Ala Xaa Val Gly His Tyr Xaa Ala Val Gln Asn 
            20                  25                  30          


Ser Lys Asn Ala Lys Asp Lys Asn Leu Lys Arg His Ser Ile Ile Ser 
        35                  40                  45              


Val Leu Pro Trp Lys Arg Ile Val Ala Val Ser Ala Lys Lys Lys Asn 
    50                  55                  60                  


Ser Lys Lys Val Gln Pro Asn Ser Ser Tyr Gln Asn Asn Ile Xaa His 
65                  70                  75                  80  


Leu Asn Asn Glu Asn Leu Lys Lys Ser Leu Ser Cys Ala Asn Leu Ser 
                85                  90                  95      


Xaa Phe Ala Gln Pro Pro Pro Ala Gln Pro Pro Ala Pro Pro Ala Ser 
            100                 105                 110         


Gln Leu Ser Gly Ser Gln Xaa Gly Gly Ser Ser Ser Val Lys Lys Ala 
        115                 120                 125             


Pro His Pro Ala Val Xaa Ser Ala Gly Xaa Pro Lys Arg Val Ile Val 
    130                 135                 140                 


Gln Ala Ser Xaa Ser Glu Leu Leu Arg Cys Leu Gly Glu Phe Leu Cys 
145                 150                 155                 160 


Arg Arg Cys Tyr Arg Leu Lys His Leu Ser Pro Xaa Asp Pro Val Leu 
                165                 170                 175     


Trp Leu Arg Ser Val Asp Arg Ser Leu Leu Leu Gln Gly Trp Gln Asp 
            180                 185                 190         


Gln Gly Phe Ile Xaa Pro Ala Asn Val Val Phe Leu Tyr Met Leu Cys 
        195                 200                 205             


Arg Asp Val Ile Ser Ser Glu Val Gly Ser Asp His Glu Leu Gln Ala 
    210                 215                 220                 


Val Leu Leu Xaa Cys Leu Tyr Leu Ser Tyr Ser Tyr Met Gly Asn Glu 
225                 230                 235                 240 


Ile Ser Tyr Pro Leu Lys Pro Phe Leu Val Glu Ser Cys Lys Glu Ala 
                245                 250                 255     


Phe Trp Asp Arg Cys Leu Ser Val Ile Asn Leu Met Ser Ser Lys Met 
            260                 265                 270         


Leu Gln Ile Asn Ala Asp Pro His Tyr Phe Xaa Gln Val Phe Ser Asp 
        275                 280                 285             


Leu Lys Asn Glu Ser Gly Gln Glu Asp Lys Lys Arg Leu Leu Leu Gly 
    290                 295                 300                 


Leu Asp Arg 
305         


<210> 5756
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<400> 5756
Xaa Ala Lys Lys Lys Asn Ser Lys Lys Val Gln Pro Asn Ser Ser Tyr 
1               5                   10                  15      


Gln Asn Asn Ile Xaa His Leu Asn Asn Glu Asn Leu Lys Lys Ser Leu 
            20                  25                  30          


Ser Cys Ala Asn Leu Ser Xaa Phe Ala Gln Pro Pro Pro Ala Gln Pro 
        35                  40                  45              


Pro Ala Pro Pro Ala Ser Gln Leu Ser Gly Ser Gln Xaa Gly Gly Ser 
    50                  55                  60                  


Ser Ser Val Lys Lys Ala Pro His Pro Ala Val Xaa Ser Ala Gly Xaa 
65                  70                  75                  80  


Pro Lys Arg Val Ile Val Gln Ala Ser Xaa Ser Glu Leu Leu Arg Cys 
                85                  90                  95      


Leu Gly Met Leu Ser Pro Pro Arg Trp Ala Arg Ile Xaa Ser Ser Arg 
            100                 105                 110         


Pro Ser Cys 
        115 


<210> 5757
<211> 103
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 5757
Asp His Gln His Val Pro Ile Asp Ile Gln Xaa Ser Lys Leu Leu Asp 
1               5                   10                  15      


Trp Leu Val Asp Arg Arg His Cys Ser Leu Lys Trp Gln Ser Leu Val 
            20                  25                  30          


Leu Xaa Ile Arg Glu Lys Ile Asn Ala Ala Ile Gln Asp Met Pro Glu 
        35                  40                  45              


Ser Glu Glu Ile Ala Gln Leu Leu Ser Gly Ser Tyr Ile His Tyr Phe 
    50                  55                  60                  


His Cys Leu Arg Ile Leu Asp Leu Leu Lys Gly Xaa Glu Ala Ser Xaa 
65                  70                  75                  80  


Lys Asn Ile Phe Gly Arg Tyr Ser Ser Gln Arg Met Lys Ala Arg Leu 
                85                  90                  95      


Ala Gly Asp Tyr Ser Ser Val 
            100             


<210> 5758
<211> 105
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<400> 5758
Met Glu Asp His Gln His Val Pro Ile Asp Ile Gln Xaa Ser Lys Leu 
1               5                   10                  15      


Leu Asp Trp Leu Val Asp Arg Arg His Cys Ser Leu Lys Trp Gln Ser 
            20                  25                  30          


Leu Val Leu Xaa Ile Arg Glu Lys Ile Asn Ala Ala Ile Gln Asp Met 
        35                  40                  45              


Pro Glu Ser Glu Glu Ile Ala Gln Leu Leu Ser Gly Ser Tyr Ile His 
    50                  55                  60                  


Tyr Phe His Cys Leu Arg Ile Leu Asp Leu Leu Lys Gly Xaa Glu Ala 
65                  70                  75                  80  


Ser Xaa Lys Asn Ile Phe Gly Arg Tyr Ser Ser Gln Arg Met Lys Ala 
                85                  90                  95      


Arg Leu Ala Gly Asp Tyr Ser Ser Val 
            100                 105 


<210> 5759
<211> 124
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<400> 5759
Met Glu Asp His Gln His Val Pro Ile Asp Ile Gln Xaa Ser Lys Leu 
1               5                   10                  15      


Leu Asp Trp Leu Val Asp Arg Arg His Cys Ser Leu Lys Trp Gln Ser 
            20                  25                  30          


Leu Val Leu Xaa Ile Arg Glu Lys Ile Asn Ala Ala Ile Gln Asp Met 
        35                  40                  45              


Pro Glu Ser Glu Glu Ile Ala Gln Leu Leu Ser Gly Ser Tyr Ile His 
    50                  55                  60                  


Tyr Phe His Cys Leu Arg Ile Leu Asp Leu Leu Lys Gly Xaa Glu Ala 
65                  70                  75                  80  


Ser Xaa Lys Asn Ile Phe Gly Arg Tyr Ser Ser Gln Arg Met Lys Asp 
                85                  90                  95      


Trp Gln Glu Ile Ile Ala Leu Tyr Glu Lys Asp Asn Xaa Tyr Leu Ala 
            100                 105                 110         


Ser Trp Phe Gly Met Ser Xaa Met Arg Ser Pro His 
        115                 120                 


<210> 5760
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<400> 5760
Met Glu Asp His Gln His Val Pro Ile Asp Ile Gln Xaa Ser Lys Leu 
1               5                   10                  15      


Leu Asp Trp Leu Val Asp Arg Arg His Cys Ser Leu Lys Trp Gln Ser 
            20                  25                  30          


Leu Val Leu Xaa Ile Arg Glu Lys Ile Asn Ala Ala Ile Gln Asp Met 
        35                  40                  45              


Pro Glu Ser Glu Glu Ile Ala Gln Leu Leu Ser Gly Ser Tyr Ile His 
    50                  55                  60                  


Tyr Phe His Cys Leu Arg Ile Leu Asp Leu Leu Lys Gly Xaa Glu Ala 
65                  70                  75                  80  


Ser Xaa Lys Asn Ile Phe Gly Arg Tyr Ser Ser Gln Arg Met Lys Asp 
                85                  90                  95      


Trp Gln Glu Ile Ile Ala Leu Tyr Glu Lys Asp Asn Xaa Tyr Leu Gly 
            100                 105                 110         


Gly Lys Ile Asn Cys Phe 
        115             


<210> 5761
<211> 506
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<400> 5761
Met Glu Asp His Gln His Val Pro Ile Asp Ile Gln Xaa Ser Lys Leu 
1               5                   10                  15      


Leu Asp Trp Leu Val Asp Arg Arg His Cys Ser Leu Lys Trp Gln Ser 
            20                  25                  30          


Leu Val Leu Xaa Ile Arg Glu Lys Ile Asn Ala Ala Ile Gln Asp Met 
        35                  40                  45              


Pro Glu Ser Glu Glu Ile Ala Gln Leu Leu Ser Gly Ser Tyr Ile His 
    50                  55                  60                  


Tyr Phe His Cys Leu Arg Ile Leu Asp Leu Leu Lys Gly Xaa Glu Ala 
65                  70                  75                  80  


Ser Xaa Lys Asn Ile Phe Gly Arg Tyr Ser Ser Gln Arg Met Lys Asp 
                85                  90                  95      


Trp Gln Glu Ile Ile Ala Leu Tyr Glu Lys Asp Asn Xaa Tyr Leu Val 
            100                 105                 110         


Glu Leu Ser Ser Leu Leu Val Arg Asn Val Asn Tyr Glu Ile Pro Ser 
        115                 120                 125             


Leu Lys Lys Gln Ile Ala Lys Cys Gln Gln Leu Gln Gln Glu Tyr Ser 
    130                 135                 140                 


Arg Lys Glu Glu Glu Cys Gln Ala Gly Ala Ala Glu Met Arg Glu Gln 
145                 150                 155                 160 


Phe Tyr His Ser Cys Lys Gln Tyr Gly Ile Xaa Gly Glu Asn Val Arg 
                165                 170                 175     


Gly Glu Leu Leu Ala Leu Val Lys Asp Leu Pro Ser Gln Leu Ala Glu 
            180                 185                 190         


Ile Gly Ala Ala Ala Gln Gln Ser Leu Gly Glu Ala Ile Asp Val Tyr 
        195                 200                 205             


Gln Ala Ser Val Gly Phe Val Cys Glu Ser Pro Xaa Glu Gln Val Leu 
    210                 215                 220                 


Pro Met Leu Arg Phe Val Gln Lys Arg Gly Asn Ser Xaa Val Tyr Glu 
225                 230                 235                 240 


Trp Arg Xaa Gly Xaa Glu Pro Ser Val Val Glu Arg Pro His Leu Glu 
                245                 250                 255     


Glu Leu Pro Glu Gln Val Ala Glu Asp Ala Ile Asp Trp Gly Asp Phe 
            260                 265                 270         


Gly Val Glu Ala Val Ser Glu Gly Xaa Asp Ser Gly Ile Ser Ala Glu 
        275                 280                 285             


Ala Ala Gly Ile Asp Trp Gly Ile Phe Pro Glu Ser Asp Ser Lys Asp 
    290                 295                 300                 


Pro Gly Gly Asp Gly Ile Asp Trp Gly Asp Asp Ala Val Ala Leu Gln 
305                 310                 315                 320 


Ile Xaa Val Leu Glu Ala Gly Xaa Gln Ala Pro Glu Gly Val Ala Arg 
                325                 330                 335     


Gly Pro Asp Ala Leu Xaa Leu Leu Glu Tyr Xaa Glu Xaa Arg Asn Gln 
            340                 345                 350         


Phe Leu Asp Glu Leu Met Glu Leu Glu Ile Phe Leu Ala Gln Arg Ala 
        355                 360                 365             


Val Glu Leu Ser Glu Glu Ala Asp Val Leu Ser Val Ser Gln Phe Gln 
    370                 375                 380                 


Leu Ala Pro Ala Ile Leu Gln Gly Gln Xaa Lys Glu Lys Met Val Xaa 
385                 390                 395                 400 


Met Val Ser Val Leu Glu Asp Leu Ile Gly Lys Leu Xaa Ser Leu Gln 
                405                 410                 415     


Leu Gln His Leu Phe Met Ile Leu Ala Ser Pro Arg Tyr Val Asp Arg 
            420                 425                 430         


Val Xaa Glu Phe Leu Gln Gln Lys Leu Lys Gln Ser Gln Leu Leu Ala 
        435                 440                 445             


Leu Lys Lys Glu Leu Met Val Gln Lys Gln Gln Glu Ala Leu Glu Glu 
    450                 455                 460                 


Gln Ala Ala Leu Glu Pro Lys Leu Asp Leu Leu Leu Glu Lys Xaa Lys 
465                 470                 475                 480 


Glu Leu Gln Lys Leu Ile Glu Ala Asp Ile Ser Lys Arg Tyr Ser Gly 
                485                 490                 495     


Arg Pro Val Asn Leu Met Gly Xaa Ser Leu 
            500                 505     


<210> 5762
<211> 281
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<400> 5762
Met Glu Asp His Gln His Val Pro Ile Asp Ile Gln Xaa Ser Lys Leu 
1               5                   10                  15      


Leu Asp Trp Leu Val Asp Arg Arg His Cys Ser Leu Lys Trp Gln Ser 
            20                  25                  30          


Leu Val Leu Xaa Ile Arg Glu Lys Ile Asn Ala Ala Ile Gln Asp Met 
        35                  40                  45              


Pro Glu Ser Glu Glu Ile Ala Gln Leu Leu Ser Gly Ser Tyr Ile His 
    50                  55                  60                  


Tyr Phe His Cys Leu Arg Ile Leu Asp Leu Leu Lys Gly Xaa Glu Ala 
65                  70                  75                  80  


Ser Xaa Lys Asn Ile Phe Gly Arg Tyr Ser Ser Gln Arg Met Lys Asp 
                85                  90                  95      


Trp Gln Glu Ile Ile Ala Leu Tyr Glu Lys Asp Asn Xaa Tyr Leu Val 
            100                 105                 110         


Glu Leu Ser Ser Leu Leu Val Arg Asn Val Asn Tyr Glu Ile Pro Ser 
        115                 120                 125             


Leu Lys Lys Gln Ile Ala Lys Cys Gln Gln Leu Gln Gln Glu Tyr Ser 
    130                 135                 140                 


Arg Lys Glu Glu Glu Cys Gln Ala Gly Ala Ala Glu Met Arg Glu Gln 
145                 150                 155                 160 


Phe Tyr His Ser Cys Lys Gln Tyr Gly Ile Xaa Gly Glu Asn Val Arg 
                165                 170                 175     


Gly Glu Leu Leu Ala Leu Val Lys Asp Leu Pro Ser Gln Leu Ala Glu 
            180                 185                 190         


Ile Gly Ala Ala Ala Gln Gln Ser Leu Gly Glu Ala Ile Asp Val Tyr 
        195                 200                 205             


Gln Ala Ser Val Gly Pro Xaa Glu Gln Val Leu Pro Met Leu Arg Phe 
    210                 215                 220                 


Val Gln Lys Arg Gly Asn Ser Xaa Val Tyr Glu Trp Arg Xaa Gly Xaa 
225                 230                 235                 240 


Glu Pro Ser Val Val Glu Arg Pro His Leu Glu Glu Leu Pro Glu Gln 
                245                 250                 255     


Val Ala Glu Asp Ala Ile Asp Trp Gly Asp Phe Gly Val Glu Ala Val 
            260                 265                 270         


Ser Glu Gly Xaa Asp Ser Gly Ile Ser 
        275                 280     


<210> 5763
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 5763
Met Glu Val Trp Gly Gln Glu Leu Gly Pro Ser Ala Arg Ala His Arg 
1               5                   10                  15      


His Pro Asp Gln Gln Ala Ala Arg Leu Ala Gly Gly Gln Lys Ala Leu 
            20                  25                  30          


Gln Pro Glu Met Ala Glu Ser Gly Ala Asp Asp Pro Arg Glu Asp Gln 
        35                  40                  45              


Cys Cys His Pro Gly His Ala Arg Glu Arg Arg Asp Arg Pro Ala Ala 
    50                  55                  60                  


Val Trp Val Leu His Ser Leu Leu Ser Leu Pro Lys Asn Pro Gly Pro 
65                  70                  75                  80  


Ser Gln Arg His Arg Gly Leu His Glu Glu Tyr Phe Trp Pro Ile Leu 
                85                  90                  95      


Phe Xaa Ala Asp Glu Gly Leu Ala Gly Asp Tyr Ser Ser Val 
            100                 105                 110 


<210> 5764
<211> 48
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<400> 5764
Met Glu Val Trp Gly Gln Glu Leu Gly Val Leu Gly Xaa Gly Arg Gly 
1               5                   10                  15      


Pro Leu Xaa Cys Val Ser Gly Leu Pro Pro Glu Ala Ala Gln Pro Ser 
            20                  25                  30          


Pro Ser Leu Trp Pro Arg Ser Gly Pro Ala Gly Trp Trp Leu Gly Arg 
        35                  40                  45              


<210> 5765
<211> 123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 5765
Met Lys Asp Trp Gln Glu Ile Ile Ala Leu Tyr Glu Lys Asp Asn Xaa 
1               5                   10                  15      


Tyr Leu Val Glu Leu Ser Ser Leu Leu Val Arg Asn Val Asn Tyr Glu 
            20                  25                  30          


Ile Pro Ser Leu Lys Lys Gln Ile Ala Lys Cys Gln Gln Leu Gln Gln 
        35                  40                  45              


Glu Tyr Ser Arg Lys Glu Glu Glu Cys Gln Ala Gly Ala Ala Glu Met 
    50                  55                  60                  


Arg Glu Gln Phe Tyr His Ser Cys Lys Gln Tyr Gly Ile Xaa Gly Glu 
65                  70                  75                  80  


Asn Val Arg Gly Glu Leu Leu Ala Leu Val Lys Asp Leu Pro Ser Gln 
                85                  90                  95      


Leu Ala Glu Ile Gly Ala Ala Ala Gln Gln Ser Leu Gly Glu Ala Ile 
            100                 105                 110         


Asp Val Tyr Gln Ala Ser Val Gly Phe Val Cys 
        115                 120             


<210> 5766
<211> 58
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<400> 5766
Met Pro Glu Ser Glu Glu Ile Ala Gln Leu Leu Ser Gly Ser Tyr Ile 
1               5                   10                  15      


His Tyr Phe His Cys Leu Arg Ile Leu Asp Leu Leu Lys Gly Xaa Glu 
            20                  25                  30          


Ala Ser Xaa Lys Asn Ile Phe Gly Arg Tyr Ser Ser Gln Arg Met Lys 
        35                  40                  45              


Ala Arg Leu Ala Gly Asp Tyr Ser Ser Val 
    50                  55              


<210> 5767
<211> 64
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<400> 5767
Met Pro Glu Ser Glu Glu Ile Ala Gln Leu Leu Ser Gly Ser Tyr Ile 
1               5                   10                  15      


His Tyr Phe His Cys Leu Arg Ile Leu Asp Leu Leu Lys Gly Xaa Glu 
            20                  25                  30          


Ala Ser Xaa Lys Asn Ile Phe Gly Arg Tyr Ser Ser Gln Arg Met Lys 
        35                  40                  45              


Asp Trp Gln Glu Ile Ile Ala Leu Tyr Glu Lys Asp Asn Xaa Tyr Leu 
    50                  55                  60                  


<210> 5768
<211> 196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<400> 5768
Met Arg Arg Gln Ser Met Xaa Ser Ala Xaa Arg Asp Leu His Xaa Ala 
1               5                   10                  15      


Leu Asp Gly Lys Ala Xaa Gln Gly Gly Lys Lys Asp His Gln His Val 
            20                  25                  30          


Pro Ile Asp Ile Gln Xaa Ser Lys Leu Leu Asp Trp Leu Val Asp Arg 
        35                  40                  45              


Arg His Cys Ser Leu Lys Trp Gln Ser Leu Val Leu Xaa Ile Arg Glu 
    50                  55                  60                  


Lys Ile Asn Ala Ala Ile Gln Asp Met Pro Glu Ser Glu Glu Ile Ala 
65                  70                  75                  80  


Gln Leu Leu Ser Gly Ser Tyr Ile His Tyr Phe His Cys Leu Arg Ile 
                85                  90                  95      


Leu Asp Leu Leu Lys Gly Xaa Glu Ala Ser Xaa Lys Asn Ile Phe Gly 
            100                 105                 110         


Arg Tyr Ser Ser Gln Arg Met Lys Asp Trp Gln Glu Ile Ile Ala Leu 
        115                 120                 125             


Tyr Glu Lys Asp Asn Xaa Tyr Leu Val Glu Leu Ser Ser Leu Leu Val 
    130                 135                 140                 


Arg Asn Val Asn Tyr Glu Ile Pro Ser Leu Lys Lys Gln Ile Ala Lys 
145                 150                 155                 160 


Cys Gln Gln Leu Gln Gln Glu Tyr Ser Arg Lys Glu Glu Glu Cys Gln 
                165                 170                 175     


Ala Gly Ala Ala Glu Met Arg Glu Gln Phe Tyr His Ser Cys Lys Gln 
            180                 185                 190         


Tyr Gly Ile Xaa 
        195     


<210> 5769
<211> 531
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<400> 5769
Met Arg Arg Gln Ser Met Xaa Ser Ala Xaa Arg Asp Leu His Xaa Ala 
1               5                   10                  15      


Leu Asp Gly Lys Ala Xaa Gln Gly Gly Lys Lys Asp His Gln His Val 
            20                  25                  30          


Pro Ile Asp Ile Gln Xaa Ser Lys Leu Leu Asp Trp Leu Val Asp Arg 
        35                  40                  45              


Arg His Cys Ser Leu Lys Trp Gln Ser Leu Val Leu Xaa Ile Arg Glu 
    50                  55                  60                  


Lys Ile Asn Ala Ala Ile Gln Asp Met Pro Glu Ser Glu Glu Ile Ala 
65                  70                  75                  80  


Gln Leu Leu Ser Gly Ser Tyr Ile His Tyr Phe His Cys Leu Arg Ile 
                85                  90                  95      


Leu Asp Leu Leu Lys Gly Xaa Glu Ala Ser Xaa Lys Asn Ile Phe Gly 
            100                 105                 110         


Arg Tyr Ser Ser Gln Arg Met Lys Asp Trp Gln Glu Ile Ile Ala Leu 
        115                 120                 125             


Tyr Glu Lys Asp Asn Xaa Tyr Leu Val Glu Leu Ser Ser Leu Leu Val 
    130                 135                 140                 


Arg Asn Val Asn Tyr Glu Ile Pro Ser Leu Lys Lys Gln Ile Ala Lys 
145                 150                 155                 160 


Cys Gln Gln Leu Gln Gln Glu Tyr Ser Arg Lys Glu Glu Glu Cys Gln 
                165                 170                 175     


Ala Gly Ala Ala Glu Met Arg Glu Gln Phe Tyr His Ser Cys Lys Gln 
            180                 185                 190         


Tyr Gly Ile Xaa Gly Glu Asn Val Arg Gly Glu Leu Leu Ala Leu Val 
        195                 200                 205             


Lys Asp Leu Pro Ser Gln Leu Ala Glu Ile Gly Ala Ala Ala Gln Gln 
    210                 215                 220                 


Ser Leu Gly Glu Ala Ile Asp Val Tyr Gln Ala Ser Val Gly Phe Val 
225                 230                 235                 240 


Cys Glu Ser Pro Xaa Glu Gln Val Leu Pro Met Leu Arg Phe Val Gln 
                245                 250                 255     


Lys Arg Gly Asn Ser Xaa Val Tyr Glu Trp Arg Xaa Gly Xaa Glu Pro 
            260                 265                 270         


Ser Val Val Glu Arg Pro His Leu Glu Glu Leu Pro Glu Gln Val Ala 
        275                 280                 285             


Glu Asp Ala Ile Asp Trp Gly Asp Phe Gly Val Glu Ala Val Ser Glu 
    290                 295                 300                 


Gly Xaa Asp Ser Gly Ile Ser Ala Glu Ala Ala Gly Ile Asp Trp Gly 
305                 310                 315                 320 


Ile Phe Pro Glu Ser Asp Ser Lys Asp Pro Gly Gly Asp Gly Ile Asp 
                325                 330                 335     


Trp Gly Asp Asp Ala Val Ala Leu Gln Ile Xaa Val Leu Glu Ala Gly 
            340                 345                 350         


Xaa Gln Ala Pro Glu Gly Val Ala Arg Gly Pro Asp Ala Leu Xaa Leu 
        355                 360                 365             


Leu Glu Tyr Xaa Glu Xaa Arg Asn Gln Phe Leu Asp Glu Leu Met Glu 
    370                 375                 380                 


Leu Glu Ile Phe Leu Ala Gln Arg Ala Val Glu Leu Ser Glu Glu Ala 
385                 390                 395                 400 


Asp Val Leu Ser Val Ser Gln Phe Gln Leu Ala Pro Ala Ile Leu Gln 
                405                 410                 415     


Gly Gln Xaa Lys Glu Lys Met Val Xaa Met Val Ser Val Leu Glu Asp 
            420                 425                 430         


Leu Ile Gly Lys Leu Xaa Ser Leu Gln Leu Gln His Leu Phe Met Ile 
        435                 440                 445             


Leu Ala Ser Pro Arg Tyr Val Asp Arg Val Xaa Glu Phe Leu Gln Gln 
    450                 455                 460                 


Lys Leu Lys Gln Ser Gln Leu Leu Ala Leu Lys Lys Glu Leu Met Val 
465                 470                 475                 480 


Gln Lys Gln Gln Glu Ala Leu Glu Glu Gln Ala Ala Leu Glu Pro Lys 
                485                 490                 495     


Leu Asp Leu Leu Leu Glu Lys Xaa Lys Glu Leu Gln Lys Leu Ile Glu 
            500                 505                 510         


Ala Asp Ile Ser Lys Arg Tyr Ser Gly Arg Pro Val Asn Leu Met Gly 
        515                 520                 525             


Xaa Ser Leu 
    530     


<210> 5770
<211> 272
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<400> 5770
Xaa Asp Phe Gly Val Glu Ala Val Ser Glu Gly Xaa Asp Ser Gly Ile 
1               5                   10                  15      


Ser Ala Glu Ala Ala Gly Ile Asp Trp Gly Ile Phe Pro Glu Ser Asp 
            20                  25                  30          


Ser Lys Asp Pro Gly Gly Asp Gly Ile Asp Trp Gly Asp Asp Ala Val 
        35                  40                  45              


Ala Leu Gln Ile Xaa Val Leu Glu Ala Gly Xaa Gln Ala Pro Glu Gly 
    50                  55                  60                  


Val Ala Arg Gly Pro Asp Ala Leu Xaa Leu Leu Glu Tyr Xaa Glu Xaa 
65                  70                  75                  80  


Arg Asn Gln Phe Leu Asp Glu Leu Met Glu Leu Glu Ile Phe Leu Ala 
                85                  90                  95      


Gln Arg Ala Val Glu Leu Ser Glu Glu Ala Asp Val Leu Ser Val Ser 
            100                 105                 110         


Gln Phe Gln Leu Ala Pro Ala Ile Leu Gln Gly Gln Xaa Lys Glu Lys 
        115                 120                 125             


Met Val Xaa Met Val Ser Val Leu Glu Asp Leu Ile Gly Lys Leu Xaa 
    130                 135                 140                 


Ser Leu Gln Leu Gln His Leu Phe Met Ile Leu Ala Ser Pro Arg Tyr 
145                 150                 155                 160 


Val Asp Arg Val Xaa Glu Phe Leu Gln Gln Lys Leu Lys Gln Ser Gln 
                165                 170                 175     


Leu Leu Ala Leu Lys Lys Glu Leu Met Val Gln Lys Gln Gln Glu Ala 
            180                 185                 190         


Leu Glu Glu Gln Ala Ala Leu Glu Pro Lys Leu Asp Leu Leu Leu Glu 
        195                 200                 205             


Lys Xaa Lys Glu Leu Gln Lys Leu Ile Glu Ala Asp Ile Ser Lys Arg 
    210                 215                 220                 


Gln Lys Xaa Arg Leu Xaa Gly Arg Trp Lys Ala Xaa Gly Arg Lys Arg 
225                 230                 235                 240 


His Leu Met Val Ile Leu Ala Leu Ser Met Phe Ser Xaa Arg Ser Cys 
                245                 250                 255     


Gly Asp Trp Pro Cys Gly Leu Ser Gly Glu Asn His Arg Phe Ser Phe 
            260                 265                 270         


<210> 5771
<211> 58
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<400> 5771
Met Ala Leu Asp Val Lys Ser Arg Ala Lys Arg Tyr Glu Lys Leu Asp 
1               5                   10                  15      


Phe Leu Gly Glu Gly Gln Phe Ala Xaa Val Tyr Lys Ala Arg Asp Lys 
            20                  25                  30          


Asn Xaa Asn Gln Ile Val Ala Ile Lys Lys Glu Ser Leu Leu Val Ala 
        35                  40                  45              


Xaa Xaa Ala Val Asn Val Leu Cys His Xaa 
    50                  55              


<210> 5772
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<400> 5772
Met Ala Leu Asp Val Lys Ser Arg Ala Lys Arg Tyr Glu Lys Leu Asp 
1               5                   10                  15      


Phe Leu Gly Glu Gly Gln Phe Ala Xaa Val Tyr Lys Ala Arg Asp Lys 
            20                  25                  30          


Asn Xaa Asn Gln Ile Val Ala Ile Lys Lys Ile Lys Leu Gly His Arg 
        35                  40                  45              


Ser Glu Ala Lys Asp Ala Pro 
    50                  55  


<210> 5773
<211> 69
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<400> 5773
Met Ala Leu Asp Val Lys Ser Arg Ala Lys Arg Tyr Glu Lys Leu Asp 
1               5                   10                  15      


Phe Leu Gly Glu Gly Gln Phe Ala Xaa Val Tyr Lys Ala Arg Asp Lys 
            20                  25                  30          


Asn Xaa Asn Gln Ile Val Ala Ile Lys Lys Ile Lys Leu Gly His Arg 
        35                  40                  45              


Ser Glu Ala Lys Asp Gly Gly Ile Gly Pro Pro Ser Tyr Tyr Leu Glu 
    50                  55                  60                  


Leu Gly Cys Met Val 
65                  


<210> 5774
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<400> 5774
Met Ala Leu Asp Val Lys Ser Arg Ala Lys Arg Tyr Glu Lys Leu Asp 
1               5                   10                  15      


Phe Leu Gly Glu Gly Gln Phe Ala Xaa Val Tyr Lys Ala Arg Asp Lys 
            20                  25                  30          


Asn Xaa Asn Gln Ile Val Ala Ile Lys Lys Ile Lys Leu Gly His Arg 
        35                  40                  45              


Ser Glu Ala Lys Asp Gly Ile Asn Arg Xaa Ala Leu Arg Glu Ile Lys 
    50                  55                  60                  


Leu Leu Gln Glu Leu Ser His Pro Asn Ile Ile Ala Pro 
65                  70                  75          


<210> 5775
<211> 309
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<400> 5775
Met Ala Leu Asp Val Lys Ser Arg Ala Lys Arg Tyr Glu Lys Leu Asp 
1               5                   10                  15      


Phe Leu Gly Glu Gly Gln Phe Ala Xaa Val Tyr Lys Ala Arg Asp Lys 
            20                  25                  30          


Asn Xaa Asn Gln Ile Val Ala Ile Lys Lys Ile Lys Leu Gly His Arg 
        35                  40                  45              


Ser Glu Ala Lys Asp Gly Ile Asn Arg Xaa Ala Leu Arg Glu Ile Lys 
    50                  55                  60                  


Leu Leu Gln Glu Leu Ser His Pro Asn Ile Ile Gly Leu Leu Asp Ala 
65                  70                  75                  80  


Phe Gly His Lys Ser Asn Ile Ser Leu Val Phe Asp Phe Met Glu Xaa 
                85                  90                  95      


Asp Leu Glu Asp Leu Lys Pro Asn Asn Leu Leu Leu Asp Glu Asn Gly 
            100                 105                 110         


Val Leu Lys Leu Ala Asp Phe Gly Leu Ala Lys Ser Phe Gly Ser Pro 
        115                 120                 125             


Asn Arg Ala Tyr Xaa His Gln Val Val Xaa Arg Trp Tyr Arg Ala Pro 
    130                 135                 140                 


Glu Leu Leu Phe Gly Ala Arg Met Tyr Gly Val Gly Val Asp Met Trp 
145                 150                 155                 160 


Ala Val Gly Cys Ile Leu Ala Glu Leu Leu Leu Arg Val Pro Phe Leu 
                165                 170                 175     


Pro Gly Asp Ser Asp Leu Asp Gln Leu Xaa Arg Ile Phe Glu Xaa Leu 
            180                 185                 190         


Gly Xaa Pro Xaa Glu Glu Gln Trp Pro Asp Met Cys Ser Leu Pro Asp 
        195                 200                 205             


Tyr Val Xaa Phe Lys Ser Phe Pro Gly Ile Pro Leu His His Ile Phe 
    210                 215                 220                 


Ser Ala Ala Gly Asp Asp Leu Leu Asp Leu Ile Gln Gly Leu Phe Leu 
225                 230                 235                 240 


Phe Asn Pro Cys Ala Arg Ile Xaa Ala Xaa Gln Ala Leu Lys Met Lys 
                245                 250                 255     


Tyr Phe Ser Asn Arg Pro Gly Pro Xaa Pro Gly Cys Gln Leu Pro Arg 
            260                 265                 270         


Pro Asn Cys Pro Val Glu Xaa Leu Lys Glu Gln Ser Asn Pro Ala Leu 
        275                 280                 285             


Ala Ile Lys Arg Lys Arg Xaa Glu Ala Leu Glu Gln Gly Gly Leu Pro 
    290                 295                 300                 


Lys Lys Leu Ile Phe 
305                 


<210> 5776
<211> 346
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<400> 5776
Met Ala Leu Asp Val Lys Ser Arg Ala Lys Arg Tyr Glu Lys Leu Asp 
1               5                   10                  15      


Phe Leu Gly Glu Gly Gln Phe Ala Xaa Val Tyr Lys Ala Arg Asp Lys 
            20                  25                  30          


Asn Xaa Asn Gln Ile Val Ala Ile Lys Lys Ile Lys Leu Gly His Arg 
        35                  40                  45              


Ser Glu Ala Lys Asp Gly Ile Asn Arg Xaa Ala Leu Arg Glu Ile Lys 
    50                  55                  60                  


Leu Leu Gln Glu Leu Ser His Pro Asn Ile Ile Gly Leu Leu Asp Ala 
65                  70                  75                  80  


Phe Gly His Lys Ser Asn Ile Ser Leu Val Phe Asp Phe Met Glu Xaa 
                85                  90                  95      


Asp Leu Glu Val Ile Ile Lys Asp Asn Ser Leu Val Leu Xaa Pro Ser 
            100                 105                 110         


His Ile Lys Ala Tyr Met Leu Met Xaa Leu Gln Gly Leu Glu Tyr Leu 
        115                 120                 125             


His Gln His Trp Ile Leu His Arg Asp Leu Lys Pro Asn Asn Leu Leu 
    130                 135                 140                 


Leu Asp Glu Asn Gly Val Leu Lys Leu Ala Asp Phe Gly Leu Ala Lys 
145                 150                 155                 160 


Ser Phe Gly Ser Pro Asn Arg Ala Tyr Xaa His Gln Val Val Xaa Arg 
                165                 170                 175     


Trp Tyr Arg Ala Pro Glu Leu Leu Phe Gly Ala Arg Met Tyr Gly Val 
            180                 185                 190         


Gly Val Asp Met Trp Ala Val Gly Cys Ile Leu Ala Glu Leu Leu Leu 
        195                 200                 205             


Arg Val Pro Phe Leu Pro Gly Asp Ser Asp Leu Asp Gln Leu Xaa Arg 
    210                 215                 220                 


Ile Phe Glu Xaa Leu Gly Xaa Pro Xaa Glu Glu Gln Trp Pro Asp Met 
225                 230                 235                 240 


Cys Ser Leu Pro Asp Tyr Val Xaa Phe Lys Ser Phe Pro Gly Ile Pro 
                245                 250                 255     


Leu His His Ile Phe Ser Ala Ala Gly Asp Asp Leu Leu Asp Leu Ile 
            260                 265                 270         


Gln Gly Leu Phe Leu Phe Asn Pro Cys Ala Arg Ile Xaa Ala Xaa Gln 
        275                 280                 285             


Ala Leu Lys Met Lys Tyr Phe Ser Asn Arg Pro Gly Pro Xaa Pro Gly 
    290                 295                 300                 


Cys Gln Leu Pro Arg Pro Asn Cys Pro Val Glu Xaa Leu Lys Glu Gln 
305                 310                 315                 320 


Ser Asn Pro Ala Leu Ala Ile Lys Arg Lys Arg Xaa Glu Ala Leu Glu 
                325                 330                 335     


Gln Gly Gly Leu Pro Lys Lys Leu Ile Phe 
            340                 345     


<210> 5777
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<400> 5777
Met Ala Leu Asp Val Lys Ser Arg Ala Lys Arg Tyr Glu Lys Leu Asp 
1               5                   10                  15      


Phe Leu Gly Glu Gly Gln Phe Ala Xaa Val Tyr Lys Ala Arg Asp Lys 
            20                  25                  30          


Asn Xaa Asn Gln Ile Val Ala Ile Lys Lys Ile Lys Leu Gly His Arg 
        35                  40                  45              


Ser Glu Ala Lys Asp Gly Ile Asn Arg Xaa Ala Leu Arg Glu Ile Lys 
    50                  55                  60                  


Leu Leu Gln Glu Leu Ser His Pro Asn Ile Ile Gly Pro 
65                  70                  75          


<210> 5778
<211> 58
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<400> 5778
Met Ala Leu Asp Val Lys Ser Arg Ala Lys Arg Tyr Glu Lys Leu Asp 
1               5                   10                  15      


Phe Leu Gly Glu Gly Gln Phe Ala Xaa Val Tyr Lys Ala Arg Asp Lys 
            20                  25                  30          


Asn Xaa Asn Gln Ile Val Ala Ile Lys Lys Ile Lys Leu Gly His Arg 
        35                  40                  45              


Ser Glu Ala Lys Asp Gly Tyr Asn Lys Gly 
    50                  55              


<210> 5779
<211> 43
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<400> 5779
Met Ala Leu Asp Val Lys Ser Arg Ala Lys Arg Tyr Glu Lys Leu Asp 
1               5                   10                  15      


Phe Leu Gly Glu Gly Gln Phe Ala Xaa Val Tyr Lys Ala Arg Asp Lys 
            20                  25                  30          


Asn Xaa Asn Gln Ile Val Ala Ile Lys Lys Val 
        35                  40              


<210> 5780
<211> 149
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<400> 5780
Met Glu Xaa Asp Leu Glu Val Ile Ile Lys Asp Asn Ser Leu Val Leu 
1               5                   10                  15      


Xaa Pro Ser His Ile Lys Ala Tyr Met Leu Met Xaa Leu Gln Gly Leu 
            20                  25                  30          


Glu Tyr Leu His Gln His Trp Ile Leu His Arg Asp Leu Lys Pro Asn 
        35                  40                  45              


Asn Leu Leu Leu Asp Glu Asn Gly Val Leu Lys Leu Ala Asp Phe Gly 
    50                  55                  60                  


Leu Ala Lys Ser Phe Gly Ser Pro Asn Arg Ala Tyr Xaa His Gln Val 
65                  70                  75                  80  


Val Xaa Arg Trp Tyr Arg Ala Pro Glu Leu Leu Phe Gly Ala Arg Met 
                85                  90                  95      


Tyr Gly Val Gly Val Asp Met Trp Ala Val Gly Cys Ile Leu Ala Glu 
            100                 105                 110         


Leu Leu Leu Arg Val Pro Phe Leu Pro Gly Asp Ser Asp Leu Asp Gln 
        115                 120                 125             


Leu Xaa Arg Ile Phe Glu Xaa Leu Gly Xaa Pro Xaa Glu Glu Gln Trp 
    130                 135                 140                 


Pro Asp Met Cys Ser 
145                 


<210> 5781
<211> 253
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<400> 5781
Met Glu Xaa Asp Leu Glu Val Ile Ile Lys Asp Asn Ser Leu Val Leu 
1               5                   10                  15      


Xaa Pro Ser His Ile Lys Ala Tyr Met Leu Met Xaa Leu Gln Gly Leu 
            20                  25                  30          


Glu Tyr Leu His Gln His Trp Ile Leu His Arg Asp Leu Lys Pro Asn 
        35                  40                  45              


Asn Leu Leu Leu Asp Glu Asn Gly Val Leu Lys Leu Ala Asp Phe Gly 
    50                  55                  60                  


Leu Ala Lys Ser Phe Gly Ser Pro Asn Arg Ala Tyr Xaa His Gln Val 
65                  70                  75                  80  


Val Xaa Arg Trp Tyr Arg Ala Pro Glu Leu Leu Phe Gly Ala Arg Met 
                85                  90                  95      


Tyr Gly Val Gly Val Asp Met Trp Ala Val Gly Cys Ile Leu Ala Glu 
            100                 105                 110         


Leu Leu Leu Arg Val Pro Phe Leu Pro Gly Asp Ser Asp Leu Asp Gln 
        115                 120                 125             


Leu Xaa Arg Ile Phe Glu Xaa Leu Gly Xaa Pro Xaa Glu Glu Gln Trp 
    130                 135                 140                 


Pro Asp Met Cys Ser Leu Pro Asp Tyr Val Xaa Phe Lys Ser Phe Pro 
145                 150                 155                 160 


Gly Ile Pro Leu His His Ile Phe Ser Ala Ala Gly Asp Asp Leu Leu 
                165                 170                 175     


Asp Leu Ile Gln Gly Leu Phe Leu Phe Asn Pro Cys Ala Arg Ile Xaa 
            180                 185                 190         


Ala Xaa Gln Ala Leu Lys Met Lys Tyr Phe Ser Asn Arg Pro Gly Pro 
        195                 200                 205             


Xaa Pro Gly Cys Gln Leu Pro Arg Pro Asn Cys Pro Val Glu Xaa Leu 
    210                 215                 220                 


Lys Glu Gln Ser Asn Pro Ala Leu Ala Ile Lys Arg Lys Arg Xaa Glu 
225                 230                 235                 240 


Ala Leu Glu Gln Gly Gly Leu Pro Lys Lys Leu Ile Phe 
                245                 250             


<210> 5782
<211> 493
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(471)
<223> Selenocysteine

<400> 5782
Met Glu Lys Tyr Glu Asn Leu Gly Leu Val Gly Glu Gly Ser Tyr Gly 
1               5                   10                  15      


Met Val Met Lys Cys Arg Asn Lys Asp Xaa Gly Arg Ile Val Ala Ile 
            20                  25                  30          


Lys Lys Phe Leu Glu Ser Asp Asp Asp Lys Met Val Lys Lys Ile Ala 
        35                  40                  45              


Met Arg Glu Ile Lys Leu Leu Lys Gln Leu Arg His Glu Asn Leu Val 
    50                  55                  60                  


Asn Leu Leu Glu Val Cys Lys Lys Lys Lys Arg Trp Tyr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Val Asp His Xaa Ile Leu Asp Asp Leu Glu Leu Phe Pro Asn 
                85                  90                  95      


Gly Leu Asp Tyr Gln Val Val Gln Lys Tyr Leu Phe Gln Ile Ile Asn 
            100                 105                 110         


Gly Ile Gly Phe Cys His Ser His Asn Ile Ile His Arg Asp Ile Lys 
        115                 120                 125             


Pro Glu Asn Ile Leu Val Ser Gln Ser Gly Val Val Lys Leu Cys Asp 
    130                 135                 140                 


Phe Gly Phe Ala Arg Xaa Leu Ala Ala Pro Gly Glu Val Tyr Xaa Asp 
145                 150                 155                 160 


Tyr Val Ala Xaa Arg Trp Tyr Arg Ala Pro Glu Leu Leu Val Gly Asp 
                165                 170                 175     


Val Lys Tyr Gly Lys Ala Val Asp Val Trp Ala Ile Gly Cys Leu Val 
            180                 185                 190         


Xaa Glu Met Phe Met Gly Glu Pro Leu Phe Pro Gly Asp Ser Asp Ile 
        195                 200                 205             


Asp Gln Leu Tyr His Ile Met Met Cys Leu Gly Asn Leu Ile Pro Arg 
    210                 215                 220                 


His Gln Glu Leu Phe Asn Lys Asn Pro Val Phe Ala Gly Val Arg Leu 
225                 230                 235                 240 


Pro Glu Ile Lys Glu Arg Glu Pro Leu Glu Arg Arg Tyr Pro Lys Leu 
                245                 250                 255     


Ser Glu Val Val Ile Asp Leu Ala Lys Lys Cys Leu His Ile Asp Pro 
            260                 265                 270         


Asp Lys Arg Pro Phe Cys Ala Glu Leu Leu His His Asp Phe Phe Gln 
        275                 280                 285             


Met Asp Gly Phe Ala Glu Arg Phe Ser Gln Glu Leu Gln Leu Lys Val 
    290                 295                 300                 


Gln Lys Asp Ala Arg Asn Val Ser Leu Ser Lys Lys Ser Gln Asn Arg 
305                 310                 315                 320 


Lys Lys Glu Lys Glu Lys Asp Asp Ser Leu Val Glu Glu Arg Lys Xaa 
                325                 330                 335     


Leu Val Val Gln Asp Xaa Asn Ala Asp Pro Lys Ile Lys Asp Tyr Lys 
            340                 345                 350         


Leu Phe Lys Ile Lys Gly Ser Lys Ile Asp Gly Glu Lys Ala Glu Lys 
        355                 360                 365             


Gly Asn Arg Ala Ser Asn Ala Ser Cys Leu His Asp Ser Arg Xaa Ser 
    370                 375                 380                 


His Asn Lys Ile Val Pro Ser Xaa Ser Leu Lys Asp Cys Ser Asn Val 
385                 390                 395                 400 


Ser Val Asp His Xaa Arg Asn Pro Ser Val Ala Ile Pro Pro Leu Xaa 
                405                 410                 415     


His Asn Leu Ser Ala Val Ala Pro Ser Ile Asn Ser Gly Met Gly Xaa 
            420                 425                 430         


Glu Xaa Ile Pro Ile Gln Gly Tyr Arg Val Asp Glu Lys Xaa Lys Lys 
        435                 440                 445             


Cys Ser Ile Pro Phe Val Lys Pro Asn Arg His Ser Pro Ser Gly Ile 
    450                 455                 460                 


Tyr Asn Ile Asn Val Xaa Xaa Leu Val Ser Gly Pro Pro Leu Ser Asp 
465                 470                 475                 480 


Asp Ser Gly Ala Asp Leu Pro Gln Met Glu His Gln His 
                485                 490             


<210> 5783
<211> 570
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<400> 5783
Met Glu Lys Tyr Glu Asn Leu Gly Leu Val Gly Glu Gly Ser Tyr Gly 
1               5                   10                  15      


Met Val Met Lys Cys Arg Asn Lys Asp Xaa Gly Arg Ile Val Ala Ile 
            20                  25                  30          


Lys Lys Phe Leu Glu Ser Asp Asp Asp Lys Met Val Lys Lys Ile Ala 
        35                  40                  45              


Met Arg Glu Ile Lys Leu Leu Lys Gln Leu Arg His Glu Asn Leu Val 
    50                  55                  60                  


Asn Leu Leu Glu Val Cys Lys Lys Lys Lys Arg Trp Tyr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Val Asp His Xaa Ile Leu Asp Asp Leu Glu Leu Phe Pro Asn 
                85                  90                  95      


Gly Leu Asp Tyr Gln Val Val Gln Lys Tyr Leu Phe Gln Ile Ile Asn 
            100                 105                 110         


Gly Ile Gly Phe Cys His Ser His Asn Ile Ile His Arg Asp Ile Lys 
        115                 120                 125             


Pro Glu Asn Ile Leu Val Ser Gln Ser Gly Val Val Lys Leu Cys Asp 
    130                 135                 140                 


Phe Gly Phe Ala Arg Xaa Leu Ala Ala Pro Gly Glu Val Tyr Xaa Asp 
145                 150                 155                 160 


Tyr Val Ala Xaa Arg Trp Tyr Arg Ala Pro Glu Leu Leu Val Gly Asp 
                165                 170                 175     


Val Lys Tyr Gly Lys Ala Val Asp Val Trp Ala Ile Gly Cys Leu Val 
            180                 185                 190         


Xaa Glu Met Phe Met Gly Glu Pro Leu Phe Pro Gly Asp Ser Asp Ile 
        195                 200                 205             


Asp Gln Leu Tyr His Ile Met Met Cys Leu Gly Asn Leu Ile Pro Arg 
    210                 215                 220                 


His Gln Glu Leu Phe Asn Lys Asn Pro Val Phe Ala Gly Val Arg Leu 
225                 230                 235                 240 


Pro Glu Ile Lys Glu Arg Glu Pro Leu Glu Arg Arg Tyr Pro Lys Leu 
                245                 250                 255     


Ser Glu Val Val Ile Asp Leu Ala Lys Lys Cys Leu His Ile Asp Pro 
            260                 265                 270         


Asp Lys Arg Pro Phe Cys Ala Glu Leu Leu His His Asp Phe Phe Gln 
        275                 280                 285             


Met Asp Gly Phe Ala Glu Arg Phe Ser Gln Glu Leu Gln Leu Lys Val 
    290                 295                 300                 


Gln Lys Asp Ala Arg Asn Val Ser Leu Ser Lys Lys Ser Gln Asn Arg 
305                 310                 315                 320 


Lys Lys Glu Lys Glu Lys Asp Asp Ser Leu Val Glu Glu Arg Lys Xaa 
                325                 330                 335     


Leu Val Val Gln Asp Xaa Asn Ala Asp Pro Lys Ile Lys Asp Tyr Lys 
            340                 345                 350         


Leu Phe Lys Ile Lys Gly Ser Lys Ile Asp Gly Glu Lys Ala Glu Lys 
        355                 360                 365             


Gly Asn Arg Ala Ser Asn Ala Ser Cys Leu His Asp Ser Arg Xaa Ser 
    370                 375                 380                 


His Asn Lys Ile Val Pro Ser Xaa Ser Leu Lys Asp Cys Ser Asn Val 
385                 390                 395                 400 


Ser Val Asp His Xaa Arg Asn Pro Ser Val Ala Ile Pro Pro Leu Xaa 
                405                 410                 415     


His Asn Leu Ser Ala Val Ala Pro Ser Ile Asn Ser Gly Met Gly Xaa 
            420                 425                 430         


Glu Xaa Ile Pro Ile Gln Gly Tyr Arg Val Asp Glu Lys Xaa Lys Lys 
        435                 440                 445             


Cys Ser Ile Pro Phe Val Lys Pro Asn Arg His Ser Pro Ser Gly Ile 
    450                 455                 460                 


Tyr Asn Ile Asn Val Xaa Xaa Leu Val Ser Ser Glu Lys Asn Leu Phe 
465                 470                 475                 480 


Trp Ala Ser Lys Lys Arg Arg Glu Tyr Ser Arg Xaa Asp Val Arg Leu 
                485                 490                 495     


Pro Glu Leu Asn Tyr Asn His Leu Pro Glu Leu Arg Ala Leu Gly Gly 
            500                 505                 510         


Ile Ala Arg Asn Ser Arg Leu Xaa Lys Lys Glu Ser Lys Ile Leu Ser 
        515                 520                 525             


Glu Ser Arg Ile Pro Ser Leu Ala Ala Ile Asp Leu His Xaa Pro Ser 
    530                 535                 540                 


Ile Xaa Leu His Gln Val Ser Gly Pro Pro Leu Ser Asp Asp Ser Gly 
545                 550                 555                 560 


Ala Asp Leu Pro Gln Met Glu His Gln His 
                565                 570 


<210> 5784
<211> 58
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<400> 5784
Met Glu Lys Tyr Glu Asn Leu Gly Leu Val Gly Glu Gly Ser Tyr Gly 
1               5                   10                  15      


Met Val Met Lys Cys Arg Asn Lys Asp Xaa Gly Arg Ile Val Ala Ile 
            20                  25                  30          


Lys Lys Phe Leu Glu Ser Asp Asp Asp Lys Met Val Lys Lys Ile Ala 
        35                  40                  45              


Met Arg Glu Ile Lys Leu Leu Lys Val Ile 
    50                  55              


<210> 5785
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 5785
Met Ser Glu Pro Ala Gly Asp Val Arg Gln Asn Pro Cys Gly Ser Lys 
1               5                   10                  15      


Ala Cys Arg Arg Leu Phe Gly Pro Val Asp Ser Glu Gln Leu Ser Arg 
            20                  25                  30          


Asp Cys Asp Ala Leu Met Ala Gly Cys Ile Gln Glu Ala Arg Glu Arg 
        35                  40                  45              


Trp Asn Phe Asp Phe Val Xaa Glu Xaa Pro Leu Glu Gly Asp Phe Ala 
    50                  55                  60                  


Trp Glu Arg Val Arg Gly Leu Gly Leu Pro Lys Leu Tyr Leu Pro Xaa 
65                  70                  75                  80  


Gly Pro Arg Arg Gly Arg Asp Glu Leu Gly Gly Gly Arg Arg Pro Gly 
                85                  90                  95      


Xaa Ser Pro Ala Leu Leu Gln Gly Xaa Ala Glu Glu Asp His Val Asp 
            100                 105                 110         


Leu Ser Leu Ser Cys Xaa Leu Val Pro Arg Ser Gly Glu Gln Ala Glu 
        115                 120                 125             


Gly Ser Pro Gly Gly Pro Gly Asp Ser Gln Gly Arg Lys Arg Arg Gln 
    130                 135                 140                 


Xaa Ser Met Xaa Asp Phe Tyr His Ser Lys Arg Arg Leu Ile Phe Ser 
145                 150                 155                 160 


Lys Arg Lys Pro 
                


<210> 5786
<211> 198
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<400> 5786
Met Ser Asn Val Arg Val Ser Asn Gly Ser Pro Ser Leu Glu Arg Met 
1               5                   10                  15      


Asp Ala Arg Gln Ala Glu His Pro Lys Pro Ser Ala Cys Arg Asn Leu 
            20                  25                  30          


Phe Gly Pro Val Asp His Glu Glu Leu Xaa Arg Asp Leu Glu Lys His 
        35                  40                  45              


Cys Arg Asp Met Glu Glu Ala Ser Gln Arg Lys Trp Asn Phe Asp Phe 
    50                  55                  60                  


Gln Asn His Lys Pro Leu Glu Gly Lys Tyr Glu Trp Gln Glu Val Glu 
65                  70                  75                  80  


Lys Gly Ser Leu Pro Glu Phe Tyr Tyr Arg Pro Pro Arg Pro Pro Lys 
                85                  90                  95      


Gly Ala Cys Lys Val Pro Ala Gln Glu Ser Gln Asp Val Ser Gly Ser 
            100                 105                 110         


Arg Pro Ala Ala Pro Leu Ile Gly Ala Pro Ala Asn Ser Glu Asp Xaa 
        115                 120                 125             


His Leu Val Asp Pro Lys Xaa Asp Pro Ser Asp Ser Gln Xaa Gly Leu 
    130                 135                 140                 


Ala Glu Gln Cys Ala Gly Ile Arg Lys Arg Pro Ala Xaa Asp Asp Ser 
145                 150                 155                 160 


Ser Xaa Gln Asn Lys Arg Ala Asn Arg Xaa Glu Glu Asn Val Ser Asp 
                165                 170                 175     


Gly Ser Pro Asn Ala Gly Ser Val Glu Gln Xaa Pro Lys Lys Pro Gly 
            180                 185                 190         


Leu Arg Arg Arg Gln Xaa 
        195             


<210> 5787
<211> 205
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<400> 5787
Met Ser Asn Val Arg Val Ser Asn Gly Ser Pro Ser Leu Glu Arg Met 
1               5                   10                  15      


Asp Ala Arg Gln Ala Glu His Pro Lys Pro Ser Ala Cys Arg Asn Leu 
            20                  25                  30          


Phe Gly Pro Val Asp His Glu Glu Leu Xaa Arg Asp Leu Glu Lys His 
        35                  40                  45              


Cys Arg Asp Met Glu Glu Ala Ser Gln Arg Lys Trp Asn Phe Asp Phe 
    50                  55                  60                  


Gln Asn His Lys Pro Leu Glu Gly Lys Tyr Glu Trp Gln Glu Val Glu 
65                  70                  75                  80  


Lys Gly Ser Leu Pro Glu Phe Tyr Tyr Arg Pro Pro Arg Pro Pro Lys 
                85                  90                  95      


Gly Ala Cys Lys Val Pro Ala Gln Glu Ser Gln Asp Val Ser Gly Ser 
            100                 105                 110         


Arg Pro Ala Ala Pro Leu Ile Gly Ala Pro Ala Asn Ser Glu Asp Xaa 
        115                 120                 125             


His Leu Val Asp Pro Lys Xaa Asp Pro Ser Asp Ser Gln Xaa Gly Leu 
    130                 135                 140                 


Ala Glu Gln Cys Ala Gly Ile Arg Lys Arg Pro Ala Xaa Asp Asp Xaa 
145                 150                 155                 160 


Ser Leu Leu Asp Glu Ala Arg Lys Ile Tyr Met Lys Ile Leu Lys Ile 
                165                 170                 175     


His Ile Ala Asp Phe Met Glu Trp Xaa Ser Cys Ile Ser Xaa Glu Lys 
            180                 185                 190         


Gln Gln His Asn Asn Xaa Lys Ile Leu Gly Xaa Leu Lys 
        195                 200                 205 


<210> 5788
<211> 104
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<400> 5788
Asn Gly Ser Pro Ser Leu Glu Arg Met Asp Ala Arg Gln Ala Glu His 
1               5                   10                  15      


Pro Lys Pro Ser Ala Cys Arg Asn Leu Phe Gly Pro Val Asp His Glu 
            20                  25                  30          


Glu Leu Xaa Arg Asp Leu Glu Lys His Cys Arg Asp Met Glu Glu Ala 
        35                  40                  45              


Ser Gln Arg Lys Trp Asn Phe Asp Phe Gln Asn His Lys Pro Leu Glu 
    50                  55                  60                  


Asp Ser Ser Xaa Gln Asn Lys Arg Ala Asn Arg Xaa Glu Glu Asn Val 
65                  70                  75                  80  


Ser Asp Gly Ser Pro Asn Ala Gly Ser Val Glu Gln Xaa Pro Lys Lys 
                85                  90                  95      


Pro Gly Leu Arg Arg Arg Gln Xaa 
            100                 


<210> 5789
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<400> 5789
Met Glu Arg Leu Val Ala Arg Gly Xaa Phe Pro Val Leu Val Arg Xaa 
1               5                   10                  15      


Ser Ala Cys Arg Ser Leu Phe Gly Pro Val Asp His Glu Glu Leu Ser 
            20                  25                  30          


Arg Glu Leu Gln Ala Arg Leu Ala Glu Leu Asn Ala Glu Asp Gln Asn 
        35                  40                  45              


Arg Trp Asp Tyr Asp Phe Gln Gln Asp Met Pro Leu Arg Gly Pro Gly 
    50                  55                  60                  


Arg Leu Gln Trp Xaa Glu Val Asp Ser Asp Ser Val Pro Ala Phe Tyr 
65                  70                  75                  80  


Arg Glu Xaa Val Gln Ile Ser Ser Pro Ser Ala Arg Asp Gln Arg Leu 
                85                  90                  95      


Arg Ser Arg Arg Ala Met Ser Pro Arg Arg Val Pro Leu Gln Ala Pro 
            100                 105                 110         


Pro Leu Ala Trp Ala Arg Trp Ser Arg Pro Arg Ala Arg Gly Cys Gly 
        115                 120                 125             


Glu Pro Ile 
    130     


<210> 5790
<211> 305
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<400> 5790
Met Glu Arg Leu Val Ala Arg Gly Xaa Phe Pro Val Leu Val Arg Xaa 
1               5                   10                  15      


Ser Ala Cys Arg Ser Leu Phe Gly Pro Val Asp His Glu Glu Leu Ser 
            20                  25                  30          


Arg Glu Leu Gln Ala Arg Leu Ala Glu Leu Asn Ala Glu Asp Gln Asn 
        35                  40                  45              


Arg Trp Asp Tyr Asp Phe Gln Gln Asp Met Pro Leu Arg Gly Pro Gly 
    50                  55                  60                  


Arg Leu Gln Trp Xaa Glu Val Asp Ser Asp Ser Val Pro Ala Phe Tyr 
65                  70                  75                  80  


Arg Glu Xaa Val Gln Val Gly Arg Cys Arg Leu Leu Leu Ala Pro Arg 
                85                  90                  95      


Pro Val Ala Val Ala Val Ala Val Ser Pro Pro Leu Glu Pro Ala Ala 
            100                 105                 110         


Glu Ser Leu Asp Gly Leu Glu Glu Ala Pro Glu Gln Leu Pro Ser Val 
        115                 120                 125             


Pro Val Pro Ala Pro Ala Ser Xaa Pro Pro Pro Val Pro Val Leu Ala 
    130                 135                 140                 


Pro Ala Pro Ala Pro Ala Pro Ala Pro Val Ala Ala Pro Val Ala Ala 
145                 150                 155                 160 


Pro Val Ala Val Ala Val Leu Ala Pro Ala Pro Ala Pro Ala Pro Ala 
                165                 170                 175     


Pro Ala Pro Ala Pro Ala Pro Val Ala Ala Pro Ala Pro Ala Pro Ala 
            180                 185                 190         


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Asp Ala Ala 
        195                 200                 205             


Pro Gln Glu Ser Ala Glu Gln Gly Ala Asn Gln Gly Gln Arg Gly Gln 
    210                 215                 220                 


Glu Pro Leu Ala Asp Gln Leu His Ser Gly Ile Ser Gly Arg Pro Ala 
225                 230                 235                 240 


Ala Gly Xaa Ala Ala Ala Ser Ala Asn Gly Ala Ala Ile Lys Lys Leu 
                245                 250                 255     


Ser Gly Pro Leu Ile Ser Asp Phe Phe Ala Lys Arg Lys Arg Ser Ala 
            260                 265                 270         


Pro Glu Lys Ser Ser Gly Asp Val Pro Ala Pro Cys Pro Ser Pro Ser 
        275                 280                 285             


Ala Ala Pro Gly Val Gly Ser Val Glu Gln Xaa Pro Arg Lys Arg Leu 
    290                 295                 300                 


Arg 
305 


<210> 5791
<211> 316
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<400> 5791
Met Ser Asp Ala Ser Leu Arg Ser Xaa Ser Xaa Met Glu Arg Leu Val 
1               5                   10                  15      


Ala Arg Gly Xaa Phe Pro Val Leu Val Arg Xaa Ser Ala Cys Arg Ser 
            20                  25                  30          


Leu Phe Gly Pro Val Asp His Glu Glu Leu Ser Arg Glu Leu Gln Ala 
        35                  40                  45              


Arg Leu Ala Glu Leu Asn Ala Glu Asp Gln Asn Arg Trp Asp Tyr Asp 
    50                  55                  60                  


Phe Gln Gln Asp Met Pro Leu Arg Gly Pro Gly Arg Leu Gln Trp Xaa 
65                  70                  75                  80  


Glu Val Asp Ser Asp Ser Val Pro Ala Phe Tyr Arg Glu Xaa Val Gln 
                85                  90                  95      


Val Gly Arg Cys Arg Leu Leu Leu Ala Pro Arg Pro Val Ala Val Ala 
            100                 105                 110         


Val Ala Val Ser Pro Pro Leu Glu Pro Ala Ala Glu Ser Leu Asp Gly 
        115                 120                 125             


Leu Glu Glu Ala Pro Glu Gln Leu Pro Ser Val Pro Val Pro Ala Pro 
    130                 135                 140                 


Ala Ser Xaa Pro Pro Pro Val Pro Val Leu Ala Pro Ala Pro Ala Pro 
145                 150                 155                 160 


Ala Pro Ala Pro Val Ala Ala Pro Val Ala Ala Pro Val Ala Val Ala 
                165                 170                 175     


Val Leu Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
            180                 185                 190         


Ala Pro Val Ala Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
        195                 200                 205             


Ala Pro Ala Pro Ala Pro Ala Pro Asp Ala Ala Pro Gln Glu Ser Ala 
    210                 215                 220                 


Glu Gln Gly Ala Asn Gln Gly Gln Arg Gly Gln Glu Pro Leu Ala Asp 
225                 230                 235                 240 


Gln Leu His Ser Gly Ile Ser Gly Arg Pro Ala Ala Gly Xaa Ala Ala 
                245                 250                 255     


Ala Ser Ala Asn Gly Ala Ala Ile Lys Lys Leu Ser Gly Pro Leu Ile 
            260                 265                 270         


Ser Asp Phe Phe Ala Lys Arg Lys Arg Ser Ala Pro Glu Lys Ser Ser 
        275                 280                 285             


Gly Asp Val Pro Ala Pro Cys Pro Ser Pro Ser Ala Ala Pro Gly Val 
    290                 295                 300                 


Gly Ser Val Glu Gln Xaa Pro Arg Lys Arg Leu Arg 
305                 310                 315     


<210> 5792
<211> 116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<400> 5792
Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 
1               5                   10                  15      


Ala Xaa Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu 
            20                  25                  30          


Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro 
        35                  40                  45              


Ile Gln Val Gly Arg Gly Ser Ala Ala Gly Ala Gly Asp Gly Gly Arg 
    50                  55                  60                  


Leu Trp Arg Xaa Lys Phe Ala Gly Glu Leu Glu Ser Gly Ser Ala Ser 
65                  70                  75                  80  


Ile Leu Arg Lys Lys Gly Arg Leu Pro Gly Glu Phe Ser Glu Gly Val 
                85                  90                  95      


Cys Asn His Arg Pro Pro Pro Gly Asp Ala Leu Gly Ala Trp Glu Ala 
            100                 105                 110         


Lys Glu Glu Glu 
        115     


<210> 5793
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<400> 5793
Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 
1               5                   10                  15      


Ala Xaa Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu 
            20                  25                  30          


Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro 
        35                  40                  45              


Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu 
    50                  55                  60                  


Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Xaa Leu Xaa Arg 
65                  70                  75                  80  


Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Xaa Leu Val Val 
                85                  90                  95      


Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg 
            100                 105                 110         


Leu Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg 
        115                 120                 125             


His Pro Arg Leu Lys Glu Pro Glu Arg Leu 
    130                 135             


<210> 5794
<211> 156
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<400> 5794
Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 
1               5                   10                  15      


Ala Xaa Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu 
            20                  25                  30          


Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro 
        35                  40                  45              


Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu 
    50                  55                  60                  


Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Xaa Leu Xaa Arg 
65                  70                  75                  80  


Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Xaa Leu Val Val 
                85                  90                  95      


Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg 
            100                 105                 110         


Leu Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg 
        115                 120                 125             


Tyr Leu Arg Ala Ala Ala Gly Gly Xaa Arg Gly Ser Asn His Ala Arg 
    130                 135                 140                 


Ile Asp Ala Ala Glu Gly Pro Ser Asp Ile Pro Asp 
145                 150                 155     


<210> 5795
<211> 167
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<400> 5795
Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 
1               5                   10                  15      


Ala Xaa Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu 
            20                  25                  30          


Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro 
        35                  40                  45              


Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu 
    50                  55                  60                  


Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Xaa Leu Xaa Arg 
65                  70                  75                  80  


Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Xaa Leu Val Val 
                85                  90                  95      


Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg 
            100                 105                 110         


Leu Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg 
        115                 120                 125             


Tyr Leu Arg Ala Ala Ala Gly Gly Xaa Arg Gly Ser Asn His Ala Arg 
    130                 135                 140                 


Ile Asp Ala Ala Glu Gly Pro Ser Glu Met Ile Gly Asn His Leu Trp 
145                 150                 155                 160 


Val Cys Arg Ser Arg His Ala 
                165         


<210> 5796
<211> 105
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 5796
Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu Leu His Gly 
1               5                   10                  15      


Ala Glu Pro Asn Cys Ala Asp Pro Ala Xaa Leu Xaa Arg Pro Val His 
            20                  25                  30          


Asp Ala Ala Arg Glu Gly Phe Leu Asp Xaa Leu Val Val Leu His Arg 
        35                  40                  45              


Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg Leu Pro Val 
    50                  55                  60                  


Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg Tyr Leu Arg 
65                  70                  75                  80  


Ala Ala Ala Gly Gly Xaa Arg Gly Ser Asn His Ala Arg Ile Asp Ala 
                85                  90                  95      


Ala Glu Gly Pro Ser Asp Ile Pro Asp 
            100                 105 


<210> 5797
<211> 104
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 5797
Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu Leu His Gly 
1               5                   10                  15      


Ala Glu Pro Asn Cys Ala Asp Pro Ala Xaa Leu Xaa Arg Pro Val His 
            20                  25                  30          


Asp Ala Ala Arg Glu Gly Phe Leu Asp Xaa Leu Val Val Leu His Arg 
        35                  40                  45              


Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg Leu Pro Val 
    50                  55                  60                  


Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg Tyr Leu Arg 
65                  70                  75                  80  


Ala Ala Ala Gly Gly Xaa Arg Gly Ser Asn His Ala Arg Ile Asp Ala 
                85                  90                  95      


Ala Glu Gly Pro Ser Gly Glu Asp 
            100                 


<210> 5798
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 5798
Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu Leu His Gly 
1               5                   10                  15      


Ala Glu Pro Asn Cys Ala Asp Pro Ala Xaa Leu Xaa Arg Pro Val His 
            20                  25                  30          


Asp Ala Ala Arg Glu Gly Phe Leu Asp Xaa Leu Val Val Leu His Arg 
        35                  40                  45              


Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg Leu Pro Val 
    50                  55                  60                  


Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg Tyr Leu Arg 
65                  70                  75                  80  


Ala Ala Ala Gly Gly Xaa Arg Gly Ser Asn His Ala Arg Ile Asp Ala 
                85                  90                  95      


Ala Glu Gly Pro Ser Val Xaa Ala Ser Ile Gln Val Pro Gly Gly Glu 
            100                 105                 110         


Glu Gly Asp Phe Gly Ser Ser Tyr Ser 
        115                 120     


<210> 5799
<211> 132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 5799
Met Val Arg Arg Phe Leu Val Xaa Leu Arg Ile Arg Arg Ala Cys Gly 
1               5                   10                  15      


Pro Pro Arg Val Arg Val Phe Val Val His Ile Pro Arg Leu Xaa Gly 
            20                  25                  30          


Glu Trp Ala Ala Pro Gly Ala Pro Ala Ala Val Ala Leu Val Leu Met 
        35                  40                  45              


Leu Leu Arg Ser Gln Arg Leu Gly Gln Gln Pro Leu Pro Arg Arg Pro 
    50                  55                  60                  


Gly His Asp Asp Gly Gln Arg Pro Ser Gly Gly Ala Ala Ala Ala Pro 
65                  70                  75                  80  


Arg Arg Gly Ala Gln Leu Arg Arg Pro Arg His Ser His Pro Xaa Arg 
                85                  90                  95      


Ala Arg Arg Cys Pro Gly Gly Leu Pro Gly His Ala Gly Gly Ala Ala 
            100                 105                 110         


Pro Gly Arg Gly Ala Ala Gly Arg Ala Arg Cys Leu Gly Pro Ser Ala 
        115                 120                 125             


Arg Gly Pro Gly 
    130         


<210> 5800
<211> 126
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(117)
<223> Selenocysteine

<400> 5800
Met Ala Gln Glu Val Ser Glu Tyr Leu Ser Gln Asn Pro Arg Val Ala 
1               5                   10                  15      


Ala Trp Val Glu Ala Leu Arg Cys Asp Gly Glu Xaa Asp Lys His Trp 
            20                  25                  30          


Arg His Arg Arg Asp Phe Leu Leu Arg Asn Ala Gly Asp Leu Ala Pro 
        35                  40                  45              


Ala Gly Gly Ala Ala Ser Ala Ser Xaa Asp Glu Ala Ala Asp Ala Glu 
    50                  55                  60                  


Ser Gly Xaa Arg Asn Arg Gln Leu Gln Gln Leu Ile Ser Phe Ser Met 
65                  70                  75                  80  


Ala Trp Ala Asn His Val Phe Leu Gly Cys Arg Tyr Pro Gln Lys Val 
                85                  90                  95      


Met Asp Lys Ile Leu Ser Met Ala Glu Gly Ile Lys Val Xaa Asp Ala 
            100                 105                 110         


Pro Xaa Tyr Xaa Xaa Arg Asp Glu Leu Val Ala Lys Lys Gly 
        115                 120                 125     


<210> 5801
<211> 580
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<400> 5801
Met Ala Gln Glu Val Ser Glu Tyr Leu Ser Gln Asn Pro Arg Val Ala 
1               5                   10                  15      


Ala Trp Val Glu Ala Leu Arg Cys Asp Gly Glu Xaa Asp Lys His Trp 
            20                  25                  30          


Arg His Arg Arg Asp Phe Leu Leu Arg Asn Ala Gly Asp Leu Ala Pro 
        35                  40                  45              


Ala Gly Gly Ala Ala Ser Ala Ser Xaa Asp Glu Ala Ala Asp Ala Glu 
    50                  55                  60                  


Ser Gly Xaa Arg Asn Arg Gln Leu Gln Gln Leu Ile Ser Phe Ser Met 
65                  70                  75                  80  


Ala Trp Ala Asn His Val Phe Leu Gly Cys Arg Tyr Pro Gln Lys Val 
                85                  90                  95      


Met Asp Lys Ile Leu Ser Met Ala Glu Gly Ile Lys Val Xaa Asp Ala 
            100                 105                 110         


Pro Xaa Tyr Xaa Xaa Arg Asp Glu Leu Val Ala Lys Val Lys Lys Arg 
        115                 120                 125             


Gly Ile Ser Ser Ser Asn Glu Gly Val Glu Glu Pro Ser Lys Lys Arg 
    130                 135                 140                 


Val Ile Glu Gly Lys Asn Ser Ser Ala Val Glu Gln Asp His Ala Lys 
145                 150                 155                 160 


Xaa Ser Ala Lys Xaa Glu Arg Ala Ser Ala Gln Gln Glu Asn Ser Ser 
                165                 170                 175     


Xaa Cys Ile Gly Ser Ala Ile Lys Ser Glu Ser Gly Asn Ser Ala Arg 
            180                 185                 190         


Ser Ser Gly Ile Ser Ser Gln Asn Ser Ser Xaa Ser Asp Gly Asp Arg 
        195                 200                 205             


Ser Val Ser Ser Gln Ser Ser Ser Ser Val Ser Ser Gln Val Xaa Xaa 
    210                 215                 220                 


Ala Gly Ser Gly Lys Ala Ser Glu Ala Glu Ala Pro Asp Lys His Gly 
225                 230                 235                 240 


Ser Ala Ser Phe Val Ser Leu Leu Lys Ser Ser Val Asn Ser His Met 
                245                 250                 255     


Xaa Gln Ser Xaa Asp Ser Arg Gln Gln Ser Gly Ser Pro Lys Lys Ser 
            260                 265                 270         


Ala Leu Glu Gly Ser Ser Ala Ser Ala Ser Gln Ser Ser Ser Glu Ile 
        275                 280                 285             


Glu Val Pro Leu Leu Gly Ser Ser Gly Ser Ser Glu Val Glu Leu Pro 
    290                 295                 300                 


Leu Leu Ser Ser Lys Pro Ser Ser Glu Xaa Ala Ser Ser Gly Leu Xaa 
305                 310                 315                 320 


Ser Lys Xaa Ser Ser Glu Ala Ser Val Ser Ser Ser Val Ala Lys Asn 
                325                 330                 335     


Ser Ser Ser Ser Gly Xaa Ser Leu Leu Xaa Pro Lys Ser Ser Ser Ser 
            340                 345                 350         


Xaa Asn Xaa Ser Leu Leu Xaa Ser Lys Ser Xaa Ser Gln Val Ala Ala 
        355                 360                 365             


Ser Leu Leu Ala Ser Lys Ser Ser Ser Gln Xaa Ser Gly Ser Leu Val 
    370                 375                 380                 


Ser Lys Ser Xaa Ser Leu Ala Ser Val Ser Gln Leu Ala Ser Lys Ser 
385                 390                 395                 400 


Ser Ser Gln Xaa Ser Xaa Ser Gln Leu Pro Ser Lys Ser Xaa Ser Gln 
                405                 410                 415     


Ser Ser Glu Ser Ser Val Lys Phe Ser Cys Lys Leu Xaa Asn Glu Asp 
            420                 425                 430         


Val Lys Gln Lys Gln Pro Phe Phe Asn Arg Leu Tyr Lys Xaa Val Ala 
        435                 440                 445             


Trp Lys Leu Val Ala Val Gly Gly Phe Ser Pro Asn Val Asn His Gly 
    450                 455                 460                 


Glu Leu Leu Asn Ala Ala Ile Glu Ala Leu Lys Ala Xaa Leu Asp Val 
465                 470                 475                 480 


Phe Phe Val Pro Leu Lys Glu Leu Ala Asp Leu Pro Gln Asn Lys Ser 
                485                 490                 495     


Ser Gln Glu Ser Ile Val Cys Glu Leu Arg Cys Lys Ser Val Tyr Leu 
            500                 505                 510         


Gly Xaa Gly Cys Gly Lys Ser Lys Glu Asn Ala Lys Ala Val Ala Ser 
        515                 520                 525             


Arg Glu Ala Leu Lys Leu Phe Leu Lys Lys Lys Val Val Val Lys Ile 
    530                 535                 540                 


Cys Lys Arg Lys Tyr Arg Gly Ser Glu Ile Glu Asp Leu Val Leu Leu 
545                 550                 555                 560 


Asp Glu Glu Ser Arg Pro Val Asn Leu Pro Pro Ala Leu Lys His Pro 
                565                 570                 575     


Gln Glu Leu Leu 
            580 


<210> 5802
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(117)
<223> Selenocysteine

<400> 5802
Met Ala Gln Glu Val Ser Glu Tyr Leu Ser Gln Asn Pro Arg Val Ala 
1               5                   10                  15      


Ala Trp Val Glu Ala Leu Arg Cys Asp Gly Glu Xaa Asp Lys His Trp 
            20                  25                  30          


Arg His Arg Arg Asp Phe Leu Leu Arg Asn Ala Gly Asp Leu Ala Pro 
        35                  40                  45              


Ala Gly Gly Ala Ala Ser Ala Ser Xaa Asp Glu Ala Ala Asp Ala Glu 
    50                  55                  60                  


Ser Gly Xaa Arg Asn Arg Gln Leu Gln Gln Leu Ile Ser Phe Ser Met 
65                  70                  75                  80  


Ala Trp Ala Asn His Val Phe Leu Gly Cys Arg Tyr Pro Gln Lys Val 
                85                  90                  95      


Met Asp Lys Ile Leu Ser Met Ala Glu Gly Ile Lys Val Xaa Asp Ala 
            100                 105                 110         


Pro Xaa Tyr Xaa Xaa Arg Asp Glu Leu Val Ala Lys Val Lys Lys Arg 
        115                 120                 125             


Gly Ile Ser Ser Ser Asn Gly 
    130                 135 


<210> 5803
<211> 85
<212> PRT
<213> Homo sapiens

<400> 5803
Met Val Gly Gly Glu Ala Ala Ala Ala Val Glu Glu Leu Val Ser Gly 
1               5                   10                  15      


Val Arg Gln Ala Ala Asp Phe Ala Glu Gln Phe Arg Ser Tyr Ser Glu 
            20                  25                  30          


Ser Glu Lys Gln Trp Lys Ala Arg Met Glu Phe Ile Leu Arg His Leu 
        35                  40                  45              


Pro Asp Tyr Arg Asp Pro Pro Asp Gly Ser Gly Arg Leu Asp Gln Leu 
    50                  55                  60                  


Leu Ser Leu Ser Met Val Trp Ala Asn His Leu Phe Leu Gly Cys Ser 
65                  70                  75                  80  


Pro Arg Gly Pro Lys 
                85  


<210> 5804
<211> 116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (105)..(106)
<223> Selenocysteine

<400> 5804
Met Val Gly Gly Glu Ala Ala Ala Ala Val Glu Glu Leu Val Ser Gly 
1               5                   10                  15      


Val Arg Gln Ala Ala Asp Phe Ala Glu Gln Phe Arg Ser Tyr Ser Glu 
            20                  25                  30          


Ser Glu Lys Gln Trp Lys Ala Arg Met Glu Phe Ile Leu Arg His Leu 
        35                  40                  45              


Pro Asp Tyr Arg Asp Pro Pro Asp Gly Ser Gly Arg Leu Asp Gln Leu 
    50                  55                  60                  


Leu Ser Leu Ser Met Val Trp Ala Asn His Leu Phe Leu Gly Cys Ser 
65                  70                  75                  80  


Tyr Asn Lys Asp Leu Leu Asp Lys Val Met Glu Met Ala Asp Gly Ile 
                85                  90                  95      


Glu Val Glu Asp Leu Pro Gln Phe Xaa Xaa Arg Ser Glu Leu Met Lys 
            100                 105                 110         


Lys His Gln Ser 
        115     


<210> 5805
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 5805
Met Arg Glu Glu Asn Lys Gly Met Pro Ser Gly Gly Gly Ser Asp Glu 
1               5                   10                  15      


Gly Leu Ala Ser Ala Ala Ala Arg Gly Leu Val Glu Lys Val Arg Gln 
            20                  25                  30          


Leu Leu Glu Ala Gly Ala Asp Pro Asn Gly Val Asn Arg Phe Gly Arg 
        35                  40                  45              


Arg Ala Ile Gln Val Ala Gly Ala Pro Gly Pro Arg Arg Gln Gly Ala 
    50                  55                  60                  


Arg Glu Arg Gly Ala Arg Pro Arg Arg Ile Gly Ala Gly Xaa 
65                  70                  75              


<210> 5806
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 5806
Met Arg Glu Glu Asn Lys Gly Met Pro Ser Gly Gly Gly Ser Asp Glu 
1               5                   10                  15      


Gly Leu Ala Ser Ala Ala Ala Arg Gly Leu Val Glu Lys Val Arg Gln 
            20                  25                  30          


Leu Leu Glu Ala Gly Ala Asp Pro Asn Gly Val Asn Arg Phe Gly Arg 
        35                  40                  45              


Arg Ala Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu 
    50                  55                  60                  


Leu Leu Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Xaa Leu 
65                  70                  75                  80  


Xaa Arg Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Xaa Leu 
                85                  90                  95      


Val Val Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp 
            100                 105                 110         


Gly Arg Leu Pro Val Asp Leu Ala Glu Glu Arg Gly His Arg Asp Val 
        115                 120                 125             


Ala Gly Tyr Leu Arg Xaa Ala Xaa Gly Asp 
    130                 135             


<210> 5807
<211> 166
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<400> 5807
Met Leu Leu Glu Glu Val Arg Ala Gly Asp Arg Leu Ser Gly Ala Ala 
1               5                   10                  15      


Ala Arg Gly Asp Val Gln Glu Val Arg Arg Leu Leu His Arg Glu Leu 
            20                  25                  30          


Val His Pro Asp Ala Leu Asn Arg Phe Gly Lys Xaa Ala Leu Gln Val 
        35                  40                  45              


Met Met Phe Gly Ser Xaa Ala Ile Ala Leu Glu Leu Leu Lys Gln Gly 
    50                  55                  60                  


Ala Ser Pro Asn Val Gln Asp Xaa Ser Gly Xaa Ser Pro Val His Asp 
65                  70                  75                  80  


Ala Ala Arg Xaa Gly Phe Leu Asp Xaa Leu Lys Val Leu Val Glu His 
                85                  90                  95      


Gly Ala Asp Val Asn Val Pro Asp Gly Xaa Gly Ala Leu Pro Ile His 
            100                 105                 110         


Leu Ala Val Gln Glu Gly His Xaa Ala Val Val Ser Phe Leu Ala Ala 
        115                 120                 125             


Glu Ser Asp Leu His Arg Arg Asp Ala Arg Gly Leu Xaa Pro Leu Glu 
    130                 135                 140                 


Leu Ala Leu Gln Arg Gly Ala Gln Asp Leu Val Asp Ile Leu Gln Gly 
145                 150                 155                 160 


His Met Val Ala Pro Leu 
                165     


<210> 5808
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<400> 5808
Met His Pro Asp Leu Gly Pro Leu Cys Xaa Leu Leu Tyr Val Xaa Leu 
1               5                   10                  15      


Xaa Ile Leu Cys Ser Ser Val Ser Ser Asp Leu Ala Pro Tyr Phe Xaa 
            20                  25                  30          


Ser Glu Pro Leu Ser Ala Val Gln Lys Leu Gly Gly Pro Val Val Leu 
        35                  40                  45              


His Cys Ser Ala Gln Pro Val Xaa Xaa Arg Ile Ser Trp Leu His Asn 
    50                  55                  60                  


Gly Lys Xaa Leu Asp Gly Asn Leu Glu His Val Lys Ile His Gln Gly 
65                  70                  75                  80  


Xaa Leu Xaa Ile Leu Ser Leu Asn Ser Ser Leu Leu Gly Tyr Tyr Gln 
                85                  90                  95      


Cys Leu Ala Asn Asn Ser Ile Gly Ala Ile Val Ser Gly Pro Ala 
            100                 105                 110     


<210> 5809
<211> 143
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 5809
Met His Pro Asp Leu Gly Pro Leu Cys Xaa Leu Leu Tyr Val Xaa Leu 
1               5                   10                  15      


Xaa Ile Leu Cys Ser Ser Val Ser Ser Asp Leu Ala Pro Tyr Phe Xaa 
            20                  25                  30          


Ser Glu Pro Leu Ser Ala Val Gln Lys Leu Gly Gly Pro Val Val Leu 
        35                  40                  45              


His Cys Ser Ala Gln Pro Val Xaa Xaa Arg Ile Ser Trp Leu His Asn 
    50                  55                  60                  


Gly Lys Xaa Leu Asp Gly Asn Leu Glu His Val Lys Ile His Gln Gly 
65                  70                  75                  80  


Xaa Leu Xaa Ile Leu Ser Leu Asn Ser Ser Leu Leu Gly Tyr Tyr Gln 
                85                  90                  95      


Cys Leu Ala Asn Asn Ser Ile Gly Ala Ile Val Ser Gly Pro Ala Xaa 
            100                 105                 110         


Val Ser Val Ala Val Leu Gly Asp Phe Gly Ser Ser Xaa Lys His Val 
        115                 120                 125             


Ile Xaa Ala Glu Glu Lys Ser Ala Gly Phe Ile Gly Cys Arg Val 
    130                 135                 140             


<210> 5810
<211> 165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 5810
Met His Pro Asp Leu Gly Pro Leu Cys Xaa Leu Leu Tyr Val Xaa Leu 
1               5                   10                  15      


Xaa Ile Leu Cys Ser Ser Val Ser Ser Asp Leu Ala Pro Tyr Phe Xaa 
            20                  25                  30          


Ser Glu Pro Leu Ser Ala Val Gln Lys Leu Gly Gly Pro Val Val Leu 
        35                  40                  45              


His Cys Ser Ala Gln Pro Val Xaa Xaa Arg Ile Ser Trp Leu His Asn 
    50                  55                  60                  


Gly Lys Xaa Leu Asp Gly Asn Leu Glu His Val Lys Ile His Gln Gly 
65                  70                  75                  80  


Xaa Leu Xaa Ile Leu Ser Leu Asn Ser Ser Leu Leu Gly Tyr Tyr Gln 
                85                  90                  95      


Cys Leu Ala Asn Asn Ser Ile Gly Ala Ile Val Ser Gly Pro Ala Xaa 
            100                 105                 110         


Val Ser Val Ala Val Leu Gly Asp Phe Gly Ser Ser Xaa Lys His Val 
        115                 120                 125             


Ile Xaa Ala Glu Glu Lys Ser Ala Gly Phe Ile Gly Cys Arg Val Pro 
    130                 135                 140                 


Glu Ser Asn Pro Lys Ala Glu Val Arg Tyr Lys Ile Arg Gly Lys Trp 
145                 150                 155                 160 


Leu Glu His Ser Xaa 
                165 


<210> 5811
<211> 1264
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (996)..(996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1255)..(1255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<400> 5811
Met His Pro Asp Leu Gly Pro Leu Cys Xaa Leu Leu Tyr Val Xaa Leu 
1               5                   10                  15      


Xaa Ile Leu Cys Ser Ser Val Ser Ser Asp Leu Ala Pro Tyr Phe Xaa 
            20                  25                  30          


Ser Glu Pro Leu Ser Ala Val Gln Lys Leu Gly Gly Pro Val Val Leu 
        35                  40                  45              


His Cys Ser Ala Gln Pro Val Xaa Xaa Arg Ile Ser Trp Leu His Asn 
    50                  55                  60                  


Gly Lys Xaa Leu Asp Gly Asn Leu Glu His Val Lys Ile His Gln Gly 
65                  70                  75                  80  


Xaa Leu Xaa Ile Leu Ser Leu Asn Ser Ser Leu Leu Gly Tyr Tyr Gln 
                85                  90                  95      


Cys Leu Ala Asn Asn Ser Ile Gly Ala Ile Val Ser Gly Pro Ala Xaa 
            100                 105                 110         


Val Ser Val Ala Val Leu Gly Asp Phe Gly Ser Ser Xaa Lys His Val 
        115                 120                 125             


Ile Xaa Ala Glu Glu Lys Ser Ala Gly Phe Ile Gly Cys Arg Val Pro 
    130                 135                 140                 


Glu Ser Asn Pro Lys Ala Glu Val Arg Tyr Lys Ile Arg Gly Lys Trp 
145                 150                 155                 160 


Leu Glu His Ser Xaa Glu Asn Tyr Leu Ile Leu Pro Ser Gly Asn Leu 
                165                 170                 175     


Gln Ile Leu Asn Val Ser Leu Glu Asp Lys Gly Ser Tyr Lys Cys Ala 
            180                 185                 190         


Ala Tyr Asn Pro Val Xaa His Gln Leu Lys Val Glu Pro Ile Gly Arg 
        195                 200                 205             


Lys Leu Leu Val Ser Arg Pro Ser Ser Asp Asp Val His Ile Leu His 
    210                 215                 220                 


Pro Xaa His Ser Gln Ala Leu Ala Val Leu Ser Arg Ser Pro Val Xaa 
225                 230                 235                 240 


Leu Glu Cys Val Val Ser Gly Val Pro Ala Pro Gln Val Tyr Trp Leu 
                245                 250                 255     


Lys Asp Gly Gln Asp Ile Ala Pro Gly Ser Asn Trp Arg Arg Leu Tyr 
            260                 265                 270         


Ser His Leu Ala Xaa Asp Ser Val Asp Pro Ala Asp Ser Gly Asn Tyr 
        275                 280                 285             


Ser Cys Met Ala Gly Asn Lys Ser Gly Asp Val Lys Tyr Val Xaa Tyr 
    290                 295                 300                 


Met Val Asn Val Leu Glu His Ala Ser Ile Ser Lys Gly Leu Gln Asp 
305                 310                 315                 320 


Gln Ile Val Ser Leu Gly Ala Xaa Val His Phe Xaa Cys Asp Val His 
                325                 330                 335     


Gly Asn Pro Ala Pro Asn Cys Xaa Trp Phe His Asn Ala Gln Pro Ile 
            340                 345                 350         


His Pro Ser Ala Arg His Leu Xaa Ala Gly Asn Gly Leu Lys Ile Ser 
        355                 360                 365             


Gly Val Xaa Val Glu Asp Val Gly Met Tyr Gln Cys Val Ala Asp Asn 
    370                 375                 380                 


Gly Ile Gly Phe Met His Ser Xaa Gly Arg Leu Glu Ile Glu Asn Asp 
385                 390                 395                 400 


Gly Gly Phe Lys Pro Val Ile Ile Xaa Ala Pro Val Ser Ala Lys Val 
                405                 410                 415     


Ala Asp Gly Asp Phe Val Xaa Leu Ser Cys Asn Ala Ser Gly Leu Pro 
            420                 425                 430         


Val Pro Val Ile Arg Trp Tyr Asp Ser His Gly Leu Ile Xaa Ser His 
        435                 440                 445             


Pro Ser Gln Val Leu Arg Ser Lys Ser Arg Lys Ser Gln Leu Ser Arg 
    450                 455                 460                 


Pro Glu Gly Leu Asn Leu Glu Pro Val Tyr Phe Val Leu Ser Gln Ala 
465                 470                 475                 480 


Gly Ala Ser Ser Leu His Ile Gln Ala Val Xaa Gln Glu His Ala Gly 
                485                 490                 495     


Lys Tyr Ile Cys Glu Ala Ala Asn Glu His Gly Xaa Xaa Gln Ala Glu 
            500                 505                 510         


Ala Ser Leu Met Val Val Pro Phe Glu Xaa Asn Xaa Lys Ala Glu Xaa 
        515                 520                 525             


Val Xaa Leu Pro Asp Ala Ala Gln Asn Asp Asp Arg Ser Lys Arg Asp 
    530                 535                 540                 


Gly Ser Glu Xaa Gly Leu Leu Ser Ser Phe Pro Val Lys Val His Pro 
545                 550                 555                 560 


Ser Ala Val Glu Ser Ala Pro Glu Lys Asn Ala Ser Gly Ile Ser Val 
                565                 570                 575     


Pro Asp Ala Pro Ile Ile Leu Ser Pro Pro Gln Xaa His Xaa Pro Asp 
            580                 585                 590         


Xaa Tyr Asn Leu Val Trp Arg Ala Gly Lys Asp Gly Gly Leu Pro Ile 
        595                 600                 605             


Asn Ala Tyr Phe Val Lys Tyr Arg Lys Leu Asp Asp Gly Val Gly Met 
    610                 615                 620                 


Leu Gly Ser Trp His Xaa Val Arg Val Pro Gly Ser Glu Asn Glu Leu 
625                 630                 635                 640 


His Leu Ala Glu Leu Glu Pro Ser Ser Leu Tyr Glu Val Leu Met Val 
                645                 650                 655     


Ala Arg Ser Ala Ala Gly Glu Gly Gln Pro Ala Met Leu Xaa Phe Arg 
            660                 665                 670         


Xaa Ser Lys Glu Lys Xaa Ala Ser Ser Lys Asn Xaa Gln Ala Ser Ser 
        675                 680                 685             


Pro Pro Val Gly Ile Pro Lys Tyr Pro Val Val Ser Glu Ala Ala Asn 
    690                 695                 700                 


Asn Asn Phe Gly Val Val Leu Xaa Asp Ser Ser Arg His Ser Gly Val 
705                 710                 715                 720 


Pro Glu Ala Pro Asp Arg Pro Xaa Ile Ser Xaa Ala Ser Glu Xaa Ser 
                725                 730                 735     


Val Tyr Val Xaa Trp Ile Pro Arg Ala Asn Gly Gly Ser Pro Ile Xaa 
            740                 745                 750         


Ala Phe Lys Val Glu Tyr Lys Arg Met Arg Xaa Ser Asn Trp Leu Val 
        755                 760                 765             


Ala Ala Glu Asp Ile Pro Pro Ser Lys Leu Ser Val Glu Val Arg Ser 
    770                 775                 780                 


Leu Glu Pro Gly Ser Xaa Tyr Lys Phe Arg Val Ile Ala Ile Asn His 
785                 790                 795                 800 


Tyr Gly Glu Ser Phe Arg Ser Ser Ala Ser Arg Pro Tyr Gln Val Val 
                805                 810                 815     


Gly Phe Pro Asn Arg Phe Ser Ser Arg Pro Ile Xaa Gly Pro His Ile 
            820                 825                 830         


Ala Tyr Xaa Glu Ala Val Ser Asp Xaa Gln Ile Met Leu Lys Trp Xaa 
        835                 840                 845             


Tyr Ile Pro Ser Ser Asn Asn Asn Xaa Pro Ile Gln Gly Phe Tyr Ile 
    850                 855                 860                 


Tyr Tyr Arg Pro Xaa Asp Ser Asp Asn Asp Ser Asp Tyr Lys Arg Asp 
865                 870                 875                 880 


Val Val Glu Gly Ser Lys Gln Trp His Met Ile Gly His Leu Gln Pro 
                885                 890                 895     


Glu Xaa Ser Tyr Asp Ile Lys Met Gln Cys Phe Asn Glu Gly Gly Glu 
            900                 905                 910         


Ser Glu Phe Ser Asn Val Met Ile Cys Glu Xaa Lys Val Lys Arg Val 
        915                 920                 925             


Pro Gly Ala Ser Glu Tyr Pro Val Lys Asp Leu Ser Xaa Pro Pro Asn 
    930                 935                 940                 


Ser Leu Gly Ser Gly Gly Asn Val Gly Pro Ala Xaa Ser Pro Ala Arg 
945                 950                 955                 960 


Ser Ser Asp Met Leu Tyr Leu Ile Val Gly Cys Val Leu Gly Val Met 
                965                 970                 975     


Val Leu Ile Leu Met Val Phe Ile Ala Met Cys Leu Trp Lys Asn Arg 
            980                 985                 990         


Gln Gln Asn Xaa Ile Gln Lys Tyr  Asp Pro Pro Gly Tyr  Leu Tyr Gln 
        995                 1000                 1005             


Gly Ser  Asp Met Asn Gly Gln  Met Val Asp Tyr Xaa  Xaa Leu Ser 
    1010                 1015                 1020             


Gly Ala  Ser Gln Ile Asn Gly  Asn Val His Gly Gly  Phe Leu Xaa 
    1025                 1030                 1035             


Asn Gly  Gly Leu Ser Ser Gly  Tyr Ser His Leu His  His Lys Val 
    1040                 1045                 1050             


Pro Asn  Ala Val Asn Gly Ile  Val Asn Gly Ser Leu  Asn Gly Gly 
    1055                 1060                 1065             


Leu Tyr  Ser Gly His Ser Asn  Ser Leu Xaa Arg Xaa  His Val Asp 
    1070                 1075                 1080             


Phe Glu  His Pro His His Leu  Val Asn Gly Gly Gly  Met Tyr Xaa 
    1085                 1090                 1095             


Ala Val  Pro Gln Ile Asp Pro  Leu Glu Cys Val Asn  Cys Arg Asn 
    1100                 1105                 1110             


Cys Arg  Asn Asn Asn Arg Cys  Phe Xaa Lys Xaa Asn  Ser Xaa Phe 
    1115                 1120                 1125             


Ser Ser  Ser Pro Pro Pro Val  Val Pro Val Val Ala  Pro Tyr Pro 
    1130                 1135                 1140             


Gln Asp  Gly Leu Glu Met Lys  Pro Leu Ser His Val  Lys Val Pro 
    1145                 1150                 1155             


Val Cys  Leu Xaa Ser Ala Val  Pro Asp Cys Gly Gln  Leu Pro Glu 
    1160                 1165                 1170             


Glu Ser  Val Lys Asp Asn Val  Glu Pro Val Pro Xaa  Gln Arg Xaa 
    1175                 1180                 1185             


Cys Cys  Gln Asp Ile Val Asn  Asp Val Ser Ser Asp  Gly Ser Glu 
    1190                 1195                 1200             


Asp Pro  Ala Glu Phe Ser Arg  Gly Asp Ser Cys Ala  His Ser Glu 
    1205                 1210                 1215             


Xaa Glu  Ile Asn Ile Val Ser  Trp Asn Ala Leu Ile  Leu Pro Pro 
    1220                 1225                 1230             


Val Pro  Glu Gly Cys Ala Glu  Lys Xaa Met Trp Ser  Pro Pro Gly 
    1235                 1240                 1245             


Ile Pro  Leu Asp Ser Pro Xaa  Glu Val Leu Gln Gln  Pro Arg Glu 
    1250                 1255                 1260             


Xaa 
    


<210> 5812
<211> 1287
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (996)..(996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1278)..(1278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1287)..(1287)
<223> Selenocysteine

<400> 5812
Met His Pro Asp Leu Gly Pro Leu Cys Xaa Leu Leu Tyr Val Xaa Leu 
1               5                   10                  15      


Xaa Ile Leu Cys Ser Ser Val Ser Ser Asp Leu Ala Pro Tyr Phe Xaa 
            20                  25                  30          


Ser Glu Pro Leu Ser Ala Val Gln Lys Leu Gly Gly Pro Val Val Leu 
        35                  40                  45              


His Cys Ser Ala Gln Pro Val Xaa Xaa Arg Ile Ser Trp Leu His Asn 
    50                  55                  60                  


Gly Lys Xaa Leu Asp Gly Asn Leu Glu His Val Lys Ile His Gln Gly 
65                  70                  75                  80  


Xaa Leu Xaa Ile Leu Ser Leu Asn Ser Ser Leu Leu Gly Tyr Tyr Gln 
                85                  90                  95      


Cys Leu Ala Asn Asn Ser Ile Gly Ala Ile Val Ser Gly Pro Ala Xaa 
            100                 105                 110         


Val Ser Val Ala Val Leu Gly Asp Phe Gly Ser Ser Xaa Lys His Val 
        115                 120                 125             


Ile Xaa Ala Glu Glu Lys Ser Ala Gly Phe Ile Gly Cys Arg Val Pro 
    130                 135                 140                 


Glu Ser Asn Pro Lys Ala Glu Val Arg Tyr Lys Ile Arg Gly Lys Trp 
145                 150                 155                 160 


Leu Glu His Ser Xaa Glu Asn Tyr Leu Ile Leu Pro Ser Gly Asn Leu 
                165                 170                 175     


Gln Ile Leu Asn Val Ser Leu Glu Asp Lys Gly Ser Tyr Lys Cys Ala 
            180                 185                 190         


Ala Tyr Asn Pro Val Xaa His Gln Leu Lys Val Glu Pro Ile Gly Arg 
        195                 200                 205             


Lys Leu Leu Val Ser Arg Pro Ser Ser Asp Asp Val His Ile Leu His 
    210                 215                 220                 


Pro Xaa His Ser Gln Ala Leu Ala Val Leu Ser Arg Ser Pro Val Xaa 
225                 230                 235                 240 


Leu Glu Cys Val Val Ser Gly Val Pro Ala Pro Gln Val Tyr Trp Leu 
                245                 250                 255     


Lys Asp Gly Gln Asp Ile Ala Pro Gly Ser Asn Trp Arg Arg Leu Tyr 
            260                 265                 270         


Ser His Leu Ala Xaa Asp Ser Val Asp Pro Ala Asp Ser Gly Asn Tyr 
        275                 280                 285             


Ser Cys Met Ala Gly Asn Lys Ser Gly Asp Val Lys Tyr Val Xaa Tyr 
    290                 295                 300                 


Met Val Asn Val Leu Glu His Ala Ser Ile Ser Lys Gly Leu Gln Asp 
305                 310                 315                 320 


Gln Ile Val Ser Leu Gly Ala Xaa Val His Phe Xaa Cys Asp Val His 
                325                 330                 335     


Gly Asn Pro Ala Pro Asn Cys Xaa Trp Phe His Asn Ala Gln Pro Ile 
            340                 345                 350         


His Pro Ser Ala Arg His Leu Xaa Ala Gly Asn Gly Leu Lys Ile Ser 
        355                 360                 365             


Gly Val Xaa Val Glu Asp Val Gly Met Tyr Gln Cys Val Ala Asp Asn 
    370                 375                 380                 


Gly Ile Gly Phe Met His Ser Xaa Gly Arg Leu Glu Ile Glu Asn Asp 
385                 390                 395                 400 


Gly Gly Phe Lys Pro Val Ile Ile Xaa Ala Pro Val Ser Ala Lys Val 
                405                 410                 415     


Ala Asp Gly Asp Phe Val Xaa Leu Ser Cys Asn Ala Ser Gly Leu Pro 
            420                 425                 430         


Val Pro Val Ile Arg Trp Tyr Asp Ser His Gly Leu Ile Xaa Ser His 
        435                 440                 445             


Pro Ser Gln Val Leu Arg Ser Lys Ser Arg Lys Ser Gln Leu Ser Arg 
    450                 455                 460                 


Pro Glu Gly Leu Asn Leu Glu Pro Val Tyr Phe Val Leu Ser Gln Ala 
465                 470                 475                 480 


Gly Ala Ser Ser Leu His Ile Gln Ala Val Xaa Gln Glu His Ala Gly 
                485                 490                 495     


Lys Tyr Ile Cys Glu Ala Ala Asn Glu His Gly Xaa Xaa Gln Ala Glu 
            500                 505                 510         


Ala Ser Leu Met Val Val Pro Phe Glu Xaa Asn Xaa Lys Ala Glu Xaa 
        515                 520                 525             


Val Xaa Leu Pro Asp Ala Ala Gln Asn Asp Asp Arg Ser Lys Arg Asp 
    530                 535                 540                 


Gly Ser Glu Xaa Gly Leu Leu Ser Ser Phe Pro Val Lys Val His Pro 
545                 550                 555                 560 


Ser Ala Val Glu Ser Ala Pro Glu Lys Asn Ala Ser Gly Ile Ser Val 
                565                 570                 575     


Pro Asp Ala Pro Ile Ile Leu Ser Pro Pro Gln Xaa His Xaa Pro Asp 
            580                 585                 590         


Xaa Tyr Asn Leu Val Trp Arg Ala Gly Lys Asp Gly Gly Leu Pro Ile 
        595                 600                 605             


Asn Ala Tyr Phe Val Lys Tyr Arg Lys Leu Asp Asp Gly Val Gly Met 
    610                 615                 620                 


Leu Gly Ser Trp His Xaa Val Arg Val Pro Gly Ser Glu Asn Glu Leu 
625                 630                 635                 640 


His Leu Ala Glu Leu Glu Pro Ser Ser Leu Tyr Glu Val Leu Met Val 
                645                 650                 655     


Ala Arg Ser Ala Ala Gly Glu Gly Gln Pro Ala Met Leu Xaa Phe Arg 
            660                 665                 670         


Xaa Ser Lys Glu Lys Xaa Ala Ser Ser Lys Asn Xaa Gln Ala Ser Ser 
        675                 680                 685             


Pro Pro Val Gly Ile Pro Lys Tyr Pro Val Val Ser Glu Ala Ala Asn 
    690                 695                 700                 


Asn Asn Phe Gly Val Val Leu Xaa Asp Ser Ser Arg His Ser Gly Val 
705                 710                 715                 720 


Pro Glu Ala Pro Asp Arg Pro Xaa Ile Ser Xaa Ala Ser Glu Xaa Ser 
                725                 730                 735     


Val Tyr Val Xaa Trp Ile Pro Arg Ala Asn Gly Gly Ser Pro Ile Xaa 
            740                 745                 750         


Ala Phe Lys Val Glu Tyr Lys Arg Met Arg Xaa Ser Asn Trp Leu Val 
        755                 760                 765             


Ala Ala Glu Asp Ile Pro Pro Ser Lys Leu Ser Val Glu Val Arg Ser 
    770                 775                 780                 


Leu Glu Pro Gly Ser Xaa Tyr Lys Phe Arg Val Ile Ala Ile Asn His 
785                 790                 795                 800 


Tyr Gly Glu Ser Phe Arg Ser Ser Ala Ser Arg Pro Tyr Gln Val Val 
                805                 810                 815     


Gly Phe Pro Asn Arg Phe Ser Ser Arg Pro Ile Xaa Gly Pro His Ile 
            820                 825                 830         


Ala Tyr Xaa Glu Ala Val Ser Asp Xaa Gln Ile Met Leu Lys Trp Xaa 
        835                 840                 845             


Tyr Ile Pro Ser Ser Asn Asn Asn Xaa Pro Ile Gln Gly Phe Tyr Ile 
    850                 855                 860                 


Tyr Tyr Arg Pro Xaa Asp Ser Asp Asn Asp Ser Asp Tyr Lys Arg Asp 
865                 870                 875                 880 


Val Val Glu Gly Ser Lys Gln Trp His Met Ile Gly His Leu Gln Pro 
                885                 890                 895     


Glu Xaa Ser Tyr Asp Ile Lys Met Gln Cys Phe Asn Glu Gly Gly Glu 
            900                 905                 910         


Ser Glu Phe Ser Asn Val Met Ile Cys Glu Xaa Lys Val Lys Arg Val 
        915                 920                 925             


Pro Gly Ala Ser Glu Tyr Pro Val Lys Asp Leu Ser Xaa Pro Pro Asn 
    930                 935                 940                 


Ser Leu Gly Ser Gly Gly Asn Val Gly Pro Ala Xaa Ser Pro Ala Arg 
945                 950                 955                 960 


Ser Ser Asp Met Leu Tyr Leu Ile Val Gly Cys Val Leu Gly Val Met 
                965                 970                 975     


Val Leu Ile Leu Met Val Phe Ile Ala Met Cys Leu Trp Lys Asn Arg 
            980                 985                 990         


Gln Gln Asn Xaa Ile Gln Lys Tyr  Asp Pro Pro Gly Tyr  Leu Tyr Gln 
        995                 1000                 1005             


Gly Ser  Asp Met Asn Gly Gln  Met Val Asp Tyr Xaa  Xaa Leu Ser 
    1010                 1015                 1020             


Gly Ala  Ser Gln Ile Asn Gly  Asn Val His Gly Gly  Phe Leu Xaa 
    1025                 1030                 1035             


Asn Gly  Gly Leu Ser Ser Gly  Tyr Ser His Leu His  His Lys Val 
    1040                 1045                 1050             


Pro Asn  Ala Val Asn Gly Ile  Val Asn Gly Ser Leu  Asn Gly Gly 
    1055                 1060                 1065             


Leu Tyr  Ser Gly His Ser Asn  Ser Leu Xaa Arg Xaa  His Val Asp 
    1070                 1075                 1080             


Phe Glu  His Pro His His Leu  Val Asn Gly Gly Gly  Met Tyr Xaa 
    1085                 1090                 1095             


Ala Val  Pro Gln Ile Asp Pro  Leu Glu Cys Val Asn  Cys Arg Asn 
    1100                 1105                 1110             


Cys Arg  Asn Asn Asn Arg Cys  Phe Xaa Lys Xaa Asn  Ser Xaa Phe 
    1115                 1120                 1125             


Ser Ser  Ser Pro Pro Pro Val  Val Pro Val Val Ala  Pro Tyr Pro 
    1130                 1135                 1140             


Gln Asp  Gly Leu Glu Met Lys  Pro Leu Ser His Val  Lys Val Pro 
    1145                 1150                 1155             


Val Cys  Leu Xaa Ser Ala Val  Pro Asp Cys Gly Gln  Leu Pro Glu 
    1160                 1165                 1170             


Glu Ser  Val Lys Asp Asn Val  Glu Pro Val Pro Xaa  Gln Arg Xaa 
    1175                 1180                 1185             


Cys Cys  Gln Asp Ile Val Asn  Asp Val Ser Ser Asp  Gly Ser Glu 
    1190                 1195                 1200             


Asp Pro  Ala Glu Phe Ser Arg  Gly Gln Glu Gly Met  Ile Asn Leu 
    1205                 1210                 1215             


Arg Ile  Pro Asp His Leu Gln  Leu Ala Lys Ser Cys  Val Trp Glu 
    1220                 1225                 1230             


Gly Asp  Ser Cys Ala His Ser  Glu Xaa Glu Ile Asn  Ile Val Ser 
    1235                 1240                 1245             


Trp Asn  Ala Leu Ile Leu Pro  Pro Val Pro Glu Gly  Cys Ala Glu 
    1250                 1255                 1260             


Lys Xaa  Met Trp Ser Pro Pro  Gly Ile Pro Leu Asp  Ser Pro Xaa 
    1265                 1270                 1275             


Glu Val  Leu Gln Gln Pro Arg  Glu Xaa 
    1280                 1285         


<210> 5813
<211> 641
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<400> 5813
Met Leu Gly Ser Trp His Xaa Val Arg Val Pro Gly Ser Glu Asn Glu 
1               5                   10                  15      


Leu His Leu Ala Glu Leu Glu Pro Ser Ser Leu Tyr Glu Val Leu Met 
            20                  25                  30          


Val Ala Arg Ser Ala Ala Gly Glu Gly Gln Pro Ala Met Leu Xaa Phe 
        35                  40                  45              


Arg Xaa Ser Lys Glu Lys Xaa Ala Ser Ser Lys Asn Xaa Gln Ala Ser 
    50                  55                  60                  


Ser Pro Pro Val Gly Ile Pro Lys Tyr Pro Val Val Ser Glu Ala Ala 
65                  70                  75                  80  


Asn Asn Asn Phe Gly Val Val Leu Xaa Asp Ser Ser Arg His Ser Gly 
                85                  90                  95      


Val Pro Glu Ala Pro Asp Arg Pro Xaa Ile Ser Xaa Ala Ser Glu Xaa 
            100                 105                 110         


Ser Val Tyr Val Xaa Trp Ile Pro Arg Ala Asn Gly Gly Ser Pro Ile 
        115                 120                 125             


Xaa Ala Phe Lys Val Glu Tyr Lys Arg Met Arg Xaa Ser Asn Trp Leu 
    130                 135                 140                 


Val Ala Ala Glu Asp Ile Pro Pro Ser Lys Leu Ser Val Glu Val Arg 
145                 150                 155                 160 


Ser Leu Glu Pro Gly Ser Xaa Tyr Lys Phe Arg Val Ile Ala Ile Asn 
                165                 170                 175     


His Tyr Gly Glu Ser Phe Arg Ser Ser Ala Ser Arg Pro Tyr Gln Val 
            180                 185                 190         


Val Gly Phe Pro Asn Arg Phe Ser Ser Arg Pro Ile Xaa Gly Pro His 
        195                 200                 205             


Ile Ala Tyr Xaa Glu Ala Val Ser Asp Xaa Gln Ile Met Leu Lys Trp 
    210                 215                 220                 


Xaa Tyr Ile Pro Ser Ser Asn Asn Asn Xaa Pro Ile Gln Gly Phe Tyr 
225                 230                 235                 240 


Ile Tyr Tyr Arg Pro Xaa Asp Ser Asp Asn Asp Ser Asp Tyr Lys Arg 
                245                 250                 255     


Asp Val Val Glu Gly Ser Lys Gln Trp His Met Ile Gly His Leu Gln 
            260                 265                 270         


Pro Glu Xaa Ser Tyr Asp Ile Lys Met Gln Cys Phe Asn Glu Gly Gly 
        275                 280                 285             


Glu Ser Glu Phe Ser Asn Val Met Ile Cys Glu Xaa Lys Val Lys Arg 
    290                 295                 300                 


Val Pro Gly Ala Ser Glu Tyr Pro Val Lys Asp Leu Ser Xaa Pro Pro 
305                 310                 315                 320 


Asn Ser Leu Gly Ser Gly Gly Asn Val Gly Pro Ala Xaa Ser Pro Ala 
                325                 330                 335     


Arg Ser Ser Asp Met Leu Tyr Leu Ile Val Gly Cys Val Leu Gly Val 
            340                 345                 350         


Met Val Leu Ile Leu Met Val Phe Ile Ala Met Cys Leu Trp Lys Asn 
        355                 360                 365             


Arg Gln Gln Asn Xaa Ile Gln Lys Tyr Asp Pro Pro Gly Tyr Leu Tyr 
    370                 375                 380                 


Gln Gly Ser Asp Met Asn Gly Gln Met Val Asp Tyr Xaa Xaa Leu Ser 
385                 390                 395                 400 


Gly Ala Ser Gln Ile Asn Gly Asn Val His Gly Gly Phe Leu Xaa Asn 
                405                 410                 415     


Gly Gly Leu Ser Ser Gly Tyr Ser His Leu His His Lys Val Pro Asn 
            420                 425                 430         


Ala Val Asn Gly Ile Val Asn Gly Ser Leu Asn Gly Gly Leu Tyr Ser 
        435                 440                 445             


Gly His Ser Asn Ser Leu Xaa Arg Xaa His Val Asp Phe Glu His Pro 
    450                 455                 460                 


His His Leu Val Asn Gly Gly Gly Met Tyr Xaa Ala Val Pro Gln Ile 
465                 470                 475                 480 


Asp Pro Leu Glu Cys Val Asn Cys Arg Asn Cys Arg Asn Asn Asn Arg 
                485                 490                 495     


Cys Phe Xaa Lys Xaa Asn Ser Xaa Phe Ser Ser Ser Pro Pro Pro Val 
            500                 505                 510         


Val Pro Val Val Ala Pro Tyr Pro Gln Asp Gly Leu Glu Met Lys Pro 
        515                 520                 525             


Leu Ser His Val Lys Val Pro Val Cys Leu Xaa Ser Ala Val Pro Asp 
    530                 535                 540                 


Cys Gly Gln Leu Pro Glu Glu Ser Val Lys Asp Asn Val Glu Pro Val 
545                 550                 555                 560 


Pro Xaa Gln Arg Xaa Cys Cys Gln Asp Ile Val Asn Asp Val Ser Ser 
                565                 570                 575     


Asp Gly Ser Glu Asp Pro Ala Glu Phe Ser Arg Gly Asp Ser Cys Ala 
            580                 585                 590         


His Ser Glu Xaa Glu Ile Asn Ile Val Ser Trp Asn Ala Leu Ile Leu 
        595                 600                 605             


Pro Pro Val Pro Glu Gly Cys Ala Glu Lys Xaa Met Trp Ser Pro Pro 
    610                 615                 620                 


Gly Ile Pro Leu Asp Ser Pro Xaa Glu Val Leu Gln Gln Pro Arg Glu 
625                 630                 635                 640 


Xaa 
    


<210> 5814
<211> 650
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<400> 5814
Xaa Asp Leu Ala Pro Tyr Phe Xaa Ser Glu Pro Leu Ser Ala Val Gln 
1               5                   10                  15      


Lys Leu Gly Gly Pro Val Val Leu His Cys Ser Ala Gln Pro Val Xaa 
            20                  25                  30          


Xaa Arg Ile Ser Trp Leu His Asn Gly Lys Xaa Leu Asp Gly Asn Leu 
        35                  40                  45              


Glu His Val Lys Ile His Gln Gly Xaa Leu Xaa Ile Leu Ser Leu Asn 
    50                  55                  60                  


Ser Ser Leu Leu Gly Tyr Tyr Gln Cys Leu Ala Asn Asn Ser Ile Gly 
65                  70                  75                  80  


Ala Ile Val Ser Gly Pro Ala Xaa Val Ser Val Ala Val Leu Gly Asp 
                85                  90                  95      


Phe Gly Ser Ser Xaa Lys His Val Ile Xaa Ala Glu Glu Lys Ser Ala 
            100                 105                 110         


Gly Phe Ile Gly Cys Arg Val Pro Glu Ser Asn Pro Lys Ala Glu Val 
        115                 120                 125             


Arg Tyr Lys Ile Arg Gly Lys Trp Leu Glu His Ser Xaa Glu Asn Tyr 
    130                 135                 140                 


Leu Ile Leu Pro Ser Gly Asn Leu Gln Ile Leu Asn Val Ser Leu Glu 
145                 150                 155                 160 


Asp Lys Gly Ser Tyr Lys Cys Ala Ala Tyr Asn Pro Val Xaa His Gln 
                165                 170                 175     


Leu Lys Val Glu Pro Ile Gly Arg Lys Leu Leu Val Ser Arg Pro Ser 
            180                 185                 190         


Ser Asp Asp Val His Ile Leu His Pro Xaa His Ser Gln Ala Leu Ala 
        195                 200                 205             


Val Leu Ser Arg Ser Pro Val Xaa Leu Glu Cys Val Val Ser Gly Val 
    210                 215                 220                 


Pro Ala Pro Gln Val Tyr Trp Leu Lys Asp Gly Gln Asp Ile Ala Pro 
225                 230                 235                 240 


Gly Ser Asn Trp Arg Arg Leu Tyr Ser His Leu Ala Xaa Asp Ser Val 
                245                 250                 255     


Asp Pro Ala Asp Ser Gly Asn Tyr Ser Cys Met Ala Gly Asn Lys Ser 
            260                 265                 270         


Gly Asp Val Lys Tyr Val Xaa Tyr Met Val Asn Val Leu Glu His Ala 
        275                 280                 285             


Ser Ile Ser Lys Gly Leu Gln Asp Gln Ile Val Ser Leu Gly Ala Xaa 
    290                 295                 300                 


Val His Phe Xaa Cys Asp Val His Gly Asn Pro Ala Pro Asn Cys Xaa 
305                 310                 315                 320 


Trp Phe His Asn Ala Gln Pro Ile His Pro Ser Ala Arg His Leu Xaa 
                325                 330                 335     


Ala Gly Asn Gly Leu Lys Ile Ser Gly Val Xaa Val Glu Asp Val Gly 
            340                 345                 350         


Met Tyr Gln Cys Val Ala Asp Asn Gly Ile Gly Phe Met His Ser Xaa 
        355                 360                 365             


Gly Arg Leu Glu Ile Glu Asn Asp Gly Gly Phe Lys Pro Val Ile Ile 
    370                 375                 380                 


Xaa Ala Pro Val Ser Ala Lys Val Ala Asp Gly Asp Phe Val Xaa Leu 
385                 390                 395                 400 


Ser Cys Asn Ala Ser Gly Leu Pro Val Pro Val Ile Arg Trp Tyr Asp 
                405                 410                 415     


Ser His Gly Leu Ile Xaa Ser His Pro Ser Gln Val Leu Arg Ser Lys 
            420                 425                 430         


Ser Arg Lys Ser Gln Leu Ser Arg Pro Glu Gly Leu Asn Leu Glu Pro 
        435                 440                 445             


Val Tyr Phe Val Leu Ser Gln Ala Gly Ala Ser Ser Leu His Ile Gln 
    450                 455                 460                 


Ala Val Xaa Gln Glu His Ala Gly Lys Tyr Ile Cys Glu Ala Ala Asn 
465                 470                 475                 480 


Glu His Gly Xaa Xaa Gln Ala Glu Ala Ser Leu Met Val Val Pro Phe 
                485                 490                 495     


Glu Xaa Asn Xaa Lys Ala Glu Xaa Val Xaa Leu Pro Asp Ala Ala Gln 
            500                 505                 510         


Asn Asp Asp Arg Ser Lys Arg Asp Gly Ser Glu Xaa Gly Leu Leu Ser 
        515                 520                 525             


Ser Phe Pro Val Lys Val His Pro Ser Ala Val Glu Ser Ala Pro Glu 
    530                 535                 540                 


Lys Asn Ala Ser Gly Ile Ser Val Pro Asp Ala Pro Ile Ile Leu Ser 
545                 550                 555                 560 


Pro Pro Gln Xaa His Xaa Pro Asp Xaa Tyr Asn Leu Val Trp Arg Ala 
                565                 570                 575     


Gly Lys Asp Gly Gly Leu Pro Ile Asn Ala Tyr Phe Val Lys Tyr Arg 
            580                 585                 590         


Lys Leu Asp Asp Gly Val Gly Met Leu Gly Ser Trp His Xaa Val Arg 
        595                 600                 605             


Val Pro Gly Ser Glu Asn Glu Leu His Leu Ala Glu Leu Glu Pro Ser 
    610                 615                 620                 


Ser Leu Tyr Glu Val Leu Met Val Ala Arg Ser Ala Ala Gly Glu Gly 
625                 630                 635                 640 


Gln Pro Ala Met Leu Xaa Phe Arg Xaa Ser 
                645                 650 


<210> 5815
<211> 243
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<400> 5815
Xaa Asn Tyr Leu Ile Leu Pro Ser Gly Asn Leu Gln Ile Leu Asn Val 
1               5                   10                  15      


Ser Leu Glu Asp Lys Gly Ser Tyr Lys Cys Ala Ala Tyr Asn Pro Val 
            20                  25                  30          


Xaa His Gln Leu Lys Val Glu Pro Ile Gly Arg Lys Leu Leu Val Ser 
        35                  40                  45              


Arg Pro Ser Ser Asp Asp Val His Ile Leu His Pro Xaa His Ser Gln 
    50                  55                  60                  


Ala Leu Ala Val Leu Ser Arg Ser Pro Val Xaa Leu Glu Cys Val Val 
65                  70                  75                  80  


Ser Gly Val Pro Ala Pro Gln Val Tyr Trp Leu Lys Asp Gly Gln Asp 
                85                  90                  95      


Ile Ala Pro Gly Ser Asn Trp Arg Arg Leu Tyr Ser His Leu Ala Xaa 
            100                 105                 110         


Asp Ser Val Asp Pro Ala Asp Ser Gly Asn Tyr Ser Cys Met Ala Gly 
        115                 120                 125             


Asn Lys Ser Gly Asp Val Lys Tyr Val Xaa Tyr Met Val Asn Val Leu 
    130                 135                 140                 


Glu His Ala Ser Ile Ser Lys Gly Leu Gln Asp Gln Ile Val Ser Leu 
145                 150                 155                 160 


Gly Ala Xaa Val His Phe Xaa Cys Asp Val His Gly Asn Pro Ala Pro 
                165                 170                 175     


Asn Cys Xaa Trp Phe His Asn Ala Gln Pro Ile His Pro Ser Ala Arg 
            180                 185                 190         


His Leu Xaa Ala Gly Asn Gly Leu Lys Ile Ser Gly Val Xaa Val Glu 
        195                 200                 205             


Asp Val Gly Met Tyr Gln Cys Val Ala Asp Asn Gly Ile Gly Phe Met 
    210                 215                 220                 


His Ser Xaa Gly Arg Leu Glu Ile Glu Asn Gly Gln Glu Ile Tyr Val 
225                 230                 235                 240 


Gly Asn Val 
            


<210> 5816
<211> 461
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<400> 5816
Met Leu Glu Leu Arg His Arg Gly Ser Cys Pro Gly Pro Arg Glu Ala 
1               5                   10                  15      


Val Ser Pro Pro His Arg Glu Gly Glu Ala Ala Gly Gly Asp His Glu 
            20                  25                  30          


Xaa Glu Ser Xaa Ser Asp Lys Glu Xaa Asp Ile Asp Asp Arg Tyr Gly 
        35                  40                  45              


Asp Leu Asp Ser Arg Xaa Asp Ser Asp Ile Pro Glu Ile Pro Pro Ser 
    50                  55                  60                  


Ser Asp Arg Xaa Pro Glu Ile Leu Lys Lys Ala Leu Ser Gly Leu Ser 
65                  70                  75                  80  


Ser Arg Trp Lys Asn Trp Trp Ile Arg Gly Ile Leu Xaa Leu Xaa Met 
                85                  90                  95      


Ile Ser Leu Phe Phe Leu Ile Ile Tyr Met Gly Ser Phe Met Leu Met 
            100                 105                 110         


Leu Leu Val Leu Gly Ile Gln Val Lys Cys Phe His Glu Ile Ile Xaa 
        115                 120                 125             


Ile Gly Tyr Arg Val Tyr His Ser Tyr Asp Leu Pro Trp Phe Arg Xaa 
    130                 135                 140                 


Leu Ser Trp Tyr Phe Leu Leu Cys Val Asn Tyr Phe Phe Tyr Gly Glu 
145                 150                 155                 160 


Xaa Val Ala Asp Tyr Phe Ala Xaa Phe Val Gln Arg Glu Glu Gln Leu 
                165                 170                 175     


Gln Phe Leu Ile Arg Tyr His Arg Phe Ile Ser Phe Ala Leu Tyr Leu 
            180                 185                 190         


Ala Gly Phe Cys Met Phe Val Leu Ser Leu Val Lys Lys His Tyr Arg 
        195                 200                 205             


Leu Gln Phe Tyr Met Phe Ala Trp Xaa His Val Xaa Leu Leu Ile Xaa 
    210                 215                 220                 


Val Xaa Gln Ser His Leu Val Ile Gln Asn Leu Phe Glu Gly Met Ile 
225                 230                 235                 240 


Trp Phe Leu Val Pro Ile Ser Ser Val Ile Cys Asn Asp Ile Xaa Ala 
                245                 250                 255     


Tyr Leu Phe Gly Phe Phe Phe Gly Arg Xaa Pro Leu Ile Lys Leu Ser 
            260                 265                 270         


Pro Lys Lys Xaa Trp Glu Gly Phe Ile Gly Gly Phe Phe Ser Xaa Val 
        275                 280                 285             


Val Phe Gly Phe Ile Ala Ala Tyr Val Leu Ser Lys Tyr Gln Tyr Phe 
    290                 295                 300                 


Val Cys Pro Val Glu Tyr Arg Ser Asp Val Asn Ser Phe Val Xaa Glu 
305                 310                 315                 320 


Cys Glu Pro Ser Glu Leu Phe Gln Leu Gln Xaa Tyr Ser Leu Pro Pro 
                325                 330                 335     


Phe Leu Lys Ala Val Leu Arg Gln Glu Arg Val Ser Leu Tyr Pro Phe 
            340                 345                 350         


Gln Ile His Ser Ile Ala Leu Ser Xaa Phe Ala Ser Leu Ile Gly Pro 
        355                 360                 365             


Phe Gly Gly Phe Phe Ala Ser Gly Phe Lys Arg Ala Phe Lys Ile Lys 
    370                 375                 380                 


Asp Phe Ala Asn Xaa Ile Pro Gly His Gly Gly Ile Met Asp Arg Phe 
385                 390                 395                 400 


Asp Cys Gln Tyr Leu Met Ala Xaa Phe Val His Val Tyr Ile Xaa Ser 
                405                 410                 415     


Phe Ile Arg Gly Pro Asn Pro Ser Lys Val Leu Gln Gln Leu Leu Val 
            420                 425                 430         


Leu Gln Pro Glu Gln Gln Leu Asn Ile Tyr Lys Xaa Leu Lys Xaa His 
        435                 440                 445             


Leu Ile Glu Lys Gly Ile Leu Gln Pro Xaa Leu Lys Val 
    450                 455                 460     


<210> 5817
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<400> 5817
Met Leu Glu Leu Arg His Arg Gly Ser Cys Pro Gly Pro Arg Glu Ala 
1               5                   10                  15      


Val Ser Pro Pro His Arg Glu Gly Glu Ala Ala Gly Gly Asp His Glu 
            20                  25                  30          


Xaa Glu Ser Xaa Ser Asp Lys Val Glu Lys Leu Val Asp Xaa Trp Asn 
        35                  40                  45              


Ser His Ser Asn Tyr Asp Leu Val Val Phe Pro Asp His Leu Tyr Gly 
    50                  55                  60                  


Ile Leu His Ala Asp Ala Ser Cys Ser Gly His Pro Ser Glu Met Leu 
65                  70                  75                  80  


Pro 
    


<210> 5818
<211> 154
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<400> 5818
Met Cys Trp Xaa Arg Ile Arg Pro Gly Xaa Pro Ser Ser Pro Gly Ala 
1               5                   10                  15      


Gln Arg Pro Xaa Pro Tyr Glu Trp Met Arg Arg Ser Val Ala Ala Gly 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Lys Xaa Arg Xaa Lys Asp Lys Tyr Arg Val 
        35                  40                  45              


Val Tyr Xaa Asp His Gln Arg Leu Glu Leu Glu Lys Glu Phe His Tyr 
    50                  55                  60                  


Ser Arg Tyr Ile Xaa Ile Arg Arg Lys Ser Glu Leu Ala Ala Asn Leu 
65                  70                  75                  80  


Gly Leu Xaa Glu Arg Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Ala 
                85                  90                  95      


Lys Glu Arg Lys Val Asn Lys Lys Lys Gln Gln Gln Gln Gln Pro Pro 
            100                 105                 110         


Gln Pro Pro Met Ala His Asp Ile Xaa Ala Xaa Pro Ala Gly Pro Ser 
        115                 120                 125             


Leu Gly Gly Leu Cys Pro Ser Asn Xaa Ser Leu Leu Ala Xaa Ser Ser 
    130                 135                 140                 


Pro Met Pro Val Lys Glu Glu Phe Leu Pro 
145                 150                 


<210> 5819
<211> 265
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<400> 5819
Met Tyr Val Gly Tyr Val Leu Asp Lys Asp Ser Pro Val Tyr Pro Gly 
1               5                   10                  15      


Pro Ala Arg Pro Ala Ser Leu Gly Leu Gly Pro Gln Ala Tyr Gly Pro 
            20                  25                  30          


Pro Ala Pro Pro Pro Ala Pro Pro Gln Tyr Pro Asp Phe Ser Ser Tyr 
        35                  40                  45              


Ser His Val Glu Pro Ala Pro Ala Pro Pro Xaa Ala Trp Gly Ala Pro 
    50                  55                  60                  


Phe Pro Ala Pro Lys Asp Asp Trp Ala Ala Ala Tyr Gly Pro Gly Pro 
65                  70                  75                  80  


Ala Ala Pro Ala Ala Ser Pro Ala Ser Leu Ala Phe Gly Pro Pro Pro 
                85                  90                  95      


Asp Phe Ser Pro Val Pro Ala Pro Pro Gly Pro Gly Pro Gly Leu Leu 
            100                 105                 110         


Ala Gln Pro Leu Gly Gly Pro Gly Xaa Pro Ser Ser Pro Gly Ala Gln 
        115                 120                 125             


Arg Pro Xaa Pro Tyr Glu Trp Met Arg Arg Ser Val Ala Ala Gly Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Lys Xaa Arg Xaa Lys Asp Lys Tyr Arg Val Val 
145                 150                 155                 160 


Tyr Xaa Asp His Gln Arg Leu Glu Leu Glu Lys Glu Phe His Tyr Ser 
                165                 170                 175     


Arg Tyr Ile Xaa Ile Arg Arg Lys Ser Glu Leu Ala Ala Asn Leu Gly 
            180                 185                 190         


Leu Xaa Glu Arg Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Ala Lys 
        195                 200                 205             


Glu Arg Lys Val Asn Lys Lys Lys Gln Gln Gln Gln Gln Pro Pro Gln 
    210                 215                 220                 


Pro Pro Met Ala His Asp Ile Xaa Ala Xaa Pro Ala Gly Pro Ser Leu 
225                 230                 235                 240 


Gly Gly Leu Cys Pro Ser Asn Xaa Ser Leu Leu Ala Xaa Ser Ser Pro 
                245                 250                 255     


Met Pro Val Lys Glu Glu Phe Leu Pro 
            260                 265 


<210> 5820
<211> 313
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<400> 5820
Met Tyr Val Ser Tyr Leu Leu Asp Lys Asp Val Ser Met Tyr Pro Ser 
1               5                   10                  15      


Ser Val Arg His Ser Gly Gly Leu Asn Leu Ala Pro Gln Asn Phe Val 
            20                  25                  30          


Ser Pro Pro Gln Tyr Pro Asp Tyr Gly Gly Tyr His Val Ala Ala Ala 
        35                  40                  45              


Ala Ala Ala Ala Ala Asn Leu Asp Ser Ala Gln Ser Pro Gly Pro Ser 
    50                  55                  60                  


Trp Pro Ala Ala Tyr Gly Ala Pro Leu Arg Glu Asp Trp Asn Gly Tyr 
65                  70                  75                  80  


Ala Pro Gly Gly Ala Ala Ala Ala Ala Asn Ala Val Ala His Gly Leu 
                85                  90                  95      


Asn Gly Gly Ser Pro Ala Ala Ala Met Gly Tyr Ser Ser Pro Ala Asp 
            100                 105                 110         


Tyr His Pro His His His Pro His His His Pro His His Pro Ala Ala 
        115                 120                 125             


Ala Pro Ser Cys Ala Ser Gly Leu Leu Gln Xaa Leu Asn Pro Gly Pro 
    130                 135                 140                 


Pro Gly Pro Ala Ala Xaa Ala Ala Ala Glu Gln Leu Ser Pro Gly Gly 
145                 150                 155                 160 


Gln Arg Arg Asn Leu Cys Glu Trp Met Arg Lys Pro Ala Gln Gln Ser 
                165                 170                 175     


Leu Gly Ser Gln Val Lys Xaa Arg Xaa Lys Asp Lys Tyr Arg Val Val 
            180                 185                 190         


Tyr Xaa Asp His Gln Arg Leu Glu Leu Glu Lys Glu Phe His Tyr Ser 
        195                 200                 205             


Arg Tyr Ile Xaa Ile Arg Arg Lys Ala Glu Leu Ala Ala Xaa Leu Gly 
    210                 215                 220                 


Leu Ser Glu Arg Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Ala Lys 
225                 230                 235                 240 


Glu Arg Lys Ile Asn Lys Lys Lys Leu Gln Gln Gln Gln Gln Gln Gln 
                245                 250                 255     


Pro Pro Gln Pro Pro Pro Pro Pro Pro Gln Pro Pro Gln Pro Gln Pro 
            260                 265                 270         


Gly Pro Leu Arg Ser Val Pro Glu Pro Leu Ser Pro Val Ser Ser Leu 
        275                 280                 285             


Gln Ala Ser Val Pro Gly Ser Val Pro Gly Val Leu Gly Pro Xaa Gly 
    290                 295                 300                 


Gly Val Leu Asn Pro Xaa Val Xaa Gln 
305                 310             


<210> 5821
<211> 284
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(265)
<223> Selenocysteine

<400> 5821
Met Tyr Gly Ser Cys Leu Leu Glu Lys Glu Ala Gly Met Tyr Pro Gly 
1               5                   10                  15      


Xaa Leu Met Ser Pro Gly Gly Asp Gly Xaa Ala Gly Xaa Gly Gly Xaa 
            20                  25                  30          


Gly Gly Gly Gly Ser Pro Met Pro Ala Ser Asn Phe Ala Ala Ala Pro 
        35                  40                  45              


Ala Phe Ser His Tyr Met Gly Tyr Pro His Met Pro Ser Met Asp Pro 
    50                  55                  60                  


His Trp Pro Ser Leu Gly Val Trp Gly Ser Pro Tyr Ser Pro Pro Arg 
65                  70                  75                  80  


Glu Asp Trp Ser Val Tyr Pro Gly Pro Ser Ser Xaa Met Gly Xaa Val 
                85                  90                  95      


Pro Val Asn Asp Val Xaa Ser Ser Pro Ala Ala Phe Cys Ser Xaa Asp 
            100                 105                 110         


Tyr Ser Asn Leu Gly Pro Val Gly Gly Gly Xaa Ser Gly Ser Ser Leu 
        115                 120                 125             


Pro Gly Gln Ala Gly Gly Ser Leu Val Pro Xaa Asp Ala Gly Ala Ala 
    130                 135                 140                 


Lys Ala Ser Ser Pro Ser Arg Ser Arg His Ser Pro Tyr Ala Trp Met 
145                 150                 155                 160 


Arg Lys Xaa Val Gln Val Xaa Gly Lys Xaa Arg Xaa Lys Glu Lys Tyr 
                165                 170                 175     


Arg Val Val Tyr Xaa Asp His Gln Arg Leu Glu Leu Glu Lys Glu Phe 
            180                 185                 190         


His Cys Asn Arg Tyr Ile Xaa Ile Gln Arg Lys Ser Glu Leu Ala Val 
        195                 200                 205             


Asn Leu Gly Leu Ser Glu Arg Gln Val Lys Ile Trp Phe Gln Asn Arg 
    210                 215                 220                 


Arg Ala Lys Glu Arg Lys Met Ile Lys Lys Lys Ile Ser Gln Phe Glu 
225                 230                 235                 240 


Asn Ser Gly Gly Ser Val Gln Ser Asp Ser Asp Ser Ile Ser Pro Gly 
                245                 250                 255     


Glu Leu Pro Asn Xaa Phe Phe Xaa Xaa Pro Ser Ala Val Arg Gly Phe 
            260                 265                 270         


Gln Pro Ile Glu Ile Gln Gln Val Ile Val Ser Glu 
        275                 280                 


<210> 5822
<211> 368
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<400> 5822
Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Xaa Ala Ser Leu Leu Xaa Phe Trp Asn Pro Pro Xaa 
            20                  25                  30          


Xaa Ala Gln Leu Xaa Xaa Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Xaa Gln Gln Ala Xaa Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Xaa Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Xaa Gln Asn Asp Xaa Gly Phe Tyr Xaa Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Xaa Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Xaa Cys Glu Pro Glu Xaa Gln Asp Xaa Xaa Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Xaa Leu Xaa Leu Leu Ser Val Xaa Arg Asn 
        195                 200                 205             


Asp Xaa Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Xaa Leu Asn Val Xaa Tyr Gly Pro Asp Xaa Pro 
225                 230                 235                 240 


Xaa Ile Ser Pro Ser Asp Xaa Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Xaa Phe Gln Gln Ser Xaa Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Xaa Val Asn Asn Ser Gly Ser Tyr Xaa Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Xaa Gly Cys Asn Arg Xaa Xaa Val Lys Xaa Ile Ile Val Xaa Asp 
305                 310                 315                 320 


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
                325                 330                 335     


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
            340                 345                 350         


Ala Cys Phe Leu His Phe Gly Lys Xaa Gly Ser Ser Gly Pro Leu Gln 
        355                 360                 365             


<210> 5823
<211> 399
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<400> 5823
Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Xaa Ala Ser Leu Leu Xaa Phe Trp Asn Pro Pro Xaa 
            20                  25                  30          


Xaa Ala Gln Leu Xaa Xaa Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Xaa Gln Gln Ala Xaa Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Xaa Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Xaa Gln Asn Asp Xaa Gly Phe Tyr Xaa Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Xaa Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Xaa Cys Glu Pro Glu Xaa Gln Asp Xaa Xaa Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Xaa Leu Xaa Leu Leu Ser Val Xaa Arg Asn 
        195                 200                 205             


Asp Xaa Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Xaa Leu Asn Val Xaa Tyr Gly Pro Asp Xaa Pro 
225                 230                 235                 240 


Xaa Ile Ser Pro Ser Asp Xaa Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Xaa Phe Gln Gln Ser Xaa Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Xaa Val Asn Asn Ser Gly Ser Tyr Xaa Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Xaa Gly Cys Asn Arg Xaa Xaa Val Lys Xaa Ile Ile Val Xaa Glu 
305                 310                 315                 320 


Met Ala Phe His His Val Ala Lys Ala Gly Leu Lys Leu Leu Ser Ser 
                325                 330                 335     


Ser Asn Pro Pro Ala Ser Xaa Ser Gln Ser Ala Lys Ile Xaa Asp Asn 
            340                 345                 350         


Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly Ile 
        355                 360                 365             


Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu Ala 
    370                 375                 380                 


Cys Phe Leu His Phe Gly Lys Xaa Gly Ser Ser Gly Pro Leu Gln 
385                 390                 395                 


<210> 5824
<211> 430
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<400> 5824
Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Xaa Ala Ser Leu Leu Xaa Phe Trp Asn Pro Pro Xaa 
            20                  25                  30          


Xaa Ala Gln Leu Xaa Xaa Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Xaa Gln Gln Ala Xaa Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Xaa Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Xaa Gln Asn Asp Xaa Gly Phe Tyr Xaa Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Xaa Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Xaa Cys Glu Pro Glu Xaa Gln Asp Xaa Xaa Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Xaa Leu Xaa Leu Leu Ser Val Xaa Arg Asn 
        195                 200                 205             


Asp Xaa Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Xaa Leu Asn Val Xaa Tyr Gly Pro Asp Xaa Pro 
225                 230                 235                 240 


Xaa Ile Ser Pro Ser Asp Xaa Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Xaa Phe Gln Gln Ser Xaa Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Xaa Val Asn Asn Ser Gly Ser Tyr Xaa Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Xaa Gly Cys Asn Arg Xaa Xaa Val Lys Xaa Ile Ile Val Xaa Asp 
305                 310                 315                 320 


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
                325                 330                 335     


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
            340                 345                 350         


Ala Cys Phe Leu His Phe Gly Lys Xaa Gly Arg Ala Ser Asp Gln Arg 
        355                 360                 365             


Asp Leu Xaa Glu His Lys Pro Ser Val Ser Asn His Xaa Gln Asp His 
    370                 375                 380                 


Ser Asn Asp Pro Pro Asn Lys Met Asn Glu Val Xaa Tyr Ser Xaa Leu 
385                 390                 395                 400 


Asn Phe Glu Ala Gln Gln Pro Xaa Gln Pro Xaa Ser Ala Ser Pro Ser 
                405                 410                 415     


Leu Xaa Ala Xaa Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
            420                 425                 430 


<210> 5825
<211> 461
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<400> 5825
Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Xaa Ala Ser Leu Leu Xaa Phe Trp Asn Pro Pro Xaa 
            20                  25                  30          


Xaa Ala Gln Leu Xaa Xaa Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Xaa Gln Gln Ala Xaa Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Xaa Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Xaa Gln Asn Asp Xaa Gly Phe Tyr Xaa Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Xaa Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Xaa Cys Glu Pro Glu Xaa Gln Asp Xaa Xaa Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Xaa Leu Xaa Leu Leu Ser Val Xaa Arg Asn 
        195                 200                 205             


Asp Xaa Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Xaa Leu Asn Val Xaa Tyr Gly Pro Asp Xaa Pro 
225                 230                 235                 240 


Xaa Ile Ser Pro Ser Asp Xaa Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Xaa Phe Gln Gln Ser Xaa Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Xaa Val Asn Asn Ser Gly Ser Tyr Xaa Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Xaa Gly Cys Asn Arg Xaa Xaa Val Lys Xaa Ile Ile Val Xaa Glu 
305                 310                 315                 320 


Arg Gln Asn Leu Xaa Met Leu Pro Arg Leu Asp Ser Asn Ser Trp Ala 
                325                 330                 335     


Gln Ala Ile Leu Pro Ser Val Ser Gln Ser Ala Glu Ile Xaa Asp Asn 
            340                 345                 350         


Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly Ile 
        355                 360                 365             


Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu Ala 
    370                 375                 380                 


Cys Phe Leu His Phe Gly Lys Xaa Gly Arg Ala Ser Asp Gln Arg Asp 
385                 390                 395                 400 


Leu Xaa Glu His Lys Pro Ser Val Ser Asn His Xaa Gln Asp His Ser 
                405                 410                 415     


Asn Asp Pro Pro Asn Lys Met Asn Glu Val Xaa Tyr Ser Xaa Leu Asn 
            420                 425                 430         


Phe Glu Ala Gln Gln Pro Xaa Gln Pro Xaa Ser Ala Ser Pro Ser Leu 
        435                 440                 445             


Xaa Ala Xaa Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
    450                 455                 460     


<210> 5826
<211> 464
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<400> 5826
Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Xaa Ala Ser Leu Leu Xaa Phe Trp Asn Pro Pro Xaa 
            20                  25                  30          


Xaa Ala Gln Leu Xaa Xaa Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Xaa Gln Gln Ala Xaa Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Xaa Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Xaa Gln Asn Asp Xaa Gly Phe Tyr Xaa Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Xaa Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Xaa Cys Glu Pro Glu Xaa Gln Asp Xaa Xaa Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Xaa Leu Xaa Leu Leu Ser Val Xaa Arg Asn 
        195                 200                 205             


Asp Xaa Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Xaa Leu Asn Val Xaa Tyr Gly Pro Asp Xaa Pro 
225                 230                 235                 240 


Xaa Ile Ser Pro Ser Asp Xaa Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Xaa Phe Gln Gln Ser Xaa Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Xaa Val Asn Asn Ser Gly Ser Tyr Xaa Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Xaa Gly Cys Asn Arg Xaa Xaa Val Lys Xaa Ile Ile Val Xaa Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Xaa Xaa 
                325                 330                 335     


Val Xaa Gly Asp Lys Asp Ser Val Asn Leu Xaa Cys Ser Xaa Asn Asp 
            340                 345                 350         


Xaa Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Xaa Xaa Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Xaa Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Xaa Gly Ser Ser Gly Pro Leu Gln 
    450                 455                 460                 


<210> 5827
<211> 526
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<400> 5827
Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Xaa Ala Ser Leu Leu Xaa Phe Trp Asn Pro Pro Xaa 
            20                  25                  30          


Xaa Ala Gln Leu Xaa Xaa Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Xaa Gln Gln Ala Xaa Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Xaa Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Xaa Gln Asn Asp Xaa Gly Phe Tyr Xaa Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Xaa Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Xaa Cys Glu Pro Glu Xaa Gln Asp Xaa Xaa Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Xaa Leu Xaa Leu Leu Ser Val Xaa Arg Asn 
        195                 200                 205             


Asp Xaa Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Xaa Leu Asn Val Xaa Tyr Gly Pro Asp Xaa Pro 
225                 230                 235                 240 


Xaa Ile Ser Pro Ser Asp Xaa Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Xaa Phe Gln Gln Ser Xaa Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Xaa Val Asn Asn Ser Gly Ser Tyr Xaa Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Xaa Gly Cys Asn Arg Xaa Xaa Val Lys Xaa Ile Ile Val Xaa Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Xaa Xaa 
                325                 330                 335     


Val Xaa Gly Asp Lys Asp Ser Val Asn Leu Xaa Cys Ser Xaa Asn Asp 
            340                 345                 350         


Xaa Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Xaa Xaa Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Xaa Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Xaa Gly Arg Ala Ser Asp Gln Arg 
    450                 455                 460                 


Asp Leu Xaa Glu His Lys Pro Ser Val Ser Asn His Xaa Gln Asp His 
465                 470                 475                 480 


Ser Asn Asp Pro Pro Asn Lys Met Asn Glu Val Xaa Tyr Ser Xaa Leu 
                485                 490                 495     


Asn Phe Glu Ala Gln Gln Pro Xaa Gln Pro Xaa Ser Ala Ser Pro Ser 
            500                 505                 510         


Leu Xaa Ala Xaa Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
        515                 520                 525     


<210> 5828
<211> 94
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 5828
Met Pro Phe Asn Val Ala Glu Gly Lys Glu Val Leu Leu Leu Val His 
1               5                   10                  15      


Asn Leu Pro Gln Gln Leu Phe Gly Tyr Ser Trp Tyr Lys Gly Glu Arg 
            20                  25                  30          


Val Asp Gly Asn Arg Gln Ile Val Gly Tyr Ala Ile Gly Xaa Gln Gln 
        35                  40                  45              


Ala Xaa Pro Gly Pro Ala Asn Ser Gly Arg Glu Xaa Ile Tyr Pro Asn 
    50                  55                  60                  


Ala Ser Leu Leu Ile Gln Asn Val Xaa Gln Asn Asp Xaa Gly Phe Tyr 
65                  70                  75                  80  


Xaa Leu Gln Val Ile Lys Ser Asp Leu Val Asn Glu Glu Ala 
                85                  90                  


<210> 5829
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 5829
Met Pro Phe Asn Val Ala Glu Gly Lys Glu Val Leu Leu Leu Val His 
1               5                   10                  15      


Asn Leu Pro Gln Gln Leu Phe Gly Tyr Ser Trp Tyr Lys Gly Glu Arg 
            20                  25                  30          


Val Asp Gly Asn Arg Gln Ile Val Gly Tyr Ala Ile Gly Xaa Gln Gln 
        35                  40                  45              


Ala Xaa Pro Gly Pro Ala Asn Ser Gly Arg Glu Xaa Ile Tyr Pro Asn 
    50                  55                  60                  


Ala Ser Leu Leu Ile Gln Asn Val Xaa Gln Asn Asp Xaa Gly Phe Tyr 
65                  70                  75                  80  


Xaa Leu Gln Val Ile Lys Ser Asp Leu Val Asn Glu Glu Ala Xaa Gly 
                85                  90                  95      


Gln Phe His 
            


<210> 5830
<211> 33
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<400> 5830
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys 
1               5                   10                  15      


Glu Val Leu Leu Xaa Ala Ser Leu Leu Xaa Phe Trp Asn Pro Pro Xaa 
            20                  25                  30          


Xaa 
    


<210> 5831
<211> 344
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<400> 5831
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys 
1               5                   10                  15      


Glu Val Leu Leu Xaa Ala Ser Leu Leu Xaa Phe Trp Asn Pro Pro Xaa 
            20                  25                  30          


Xaa Ala Lys Leu Xaa Ile Glu Ser Xaa Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Xaa Gln Gln Ala Xaa Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Xaa Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Xaa Gln Asn Asp Xaa Gly Phe Tyr Xaa Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Xaa Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Xaa Cys Glu Pro Glu Val Gln Asn Xaa Xaa Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Met Xaa Leu Xaa Leu Leu Ser Val Lys Arg Asn 
        195                 200                 205             


Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Xaa Leu Asn Val Leu Tyr Gly Pro Asp Val Pro 
225                 230                 235                 240 


Xaa Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Ile Asn Gly Xaa Phe Gln Gln Ser Xaa Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Xaa Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Ala Xaa Gly Leu Asn Arg Xaa Xaa Val Xaa Met Ile Xaa Val Ser Gly 
305                 310                 315                 320 


Ser Ala Pro Val Leu Ser Ala Val Ala Xaa Val Gly Ile Xaa Ile Gly 
                325                 330                 335     


Val Leu Ala Arg Val Ala Leu Ile 
            340                 


<210> 5832
<211> 358
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<400> 5832
Met Glu Ser Ala Asp Phe Tyr Glu Ala Glu Pro Arg Pro Pro Met Ser 
1               5                   10                  15      


Ser His Leu Gln Ser Pro Pro His Ala Pro Ser Ser Ala Ala Phe Gly 
            20                  25                  30          


Phe Pro Arg Gly Ala Gly Pro Ala Gln Pro Pro Ala Pro Pro Ala Ala 
        35                  40                  45              


Pro Glu Pro Leu Gly Gly Ile Cys Glu His Glu Xaa Ser Ile Asp Ile 
    50                  55                  60                  


Ser Ala Tyr Ile Asp Pro Ala Ala Phe Asn Asp Glu Phe Leu Ala Asp 
65                  70                  75                  80  


Leu Phe Gln His Ser Arg Gln Gln Glu Lys Ala Lys Ala Ala Val Gly 
                85                  90                  95      


Pro Xaa Gly Gly Gly Gly Gly Gly Asp Phe Asp Tyr Pro Gly Ala Pro 
            100                 105                 110         


Ala Gly Pro Gly Gly Ala Val Met Pro Gly Gly Ala His Gly Pro Pro 
        115                 120                 125             


Pro Gly Tyr Gly Cys Ala Ala Ala Gly Tyr Leu Asp Gly Arg Leu Glu 
    130                 135                 140                 


Pro Leu Tyr Glu Arg Val Gly Ala Pro Ala Leu Arg Pro Leu Val Ile 
145                 150                 155                 160 


Lys Gln Glu Pro Arg Glu Glu Asp Glu Ala Lys Gln Leu Ala Leu Ala 
                165                 170                 175     


Gly Leu Phe Pro Tyr Gln Pro Pro Pro Pro Pro Pro Pro Ser His Pro 
            180                 185                 190         


His Pro His Pro Pro Pro Ala His Leu Ala Ala Pro His Leu Gln Phe 
        195                 200                 205             


Gln Ile Ala His Cys Gly Gln Xaa Xaa Met His Leu Gln Pro Gly His 
    210                 215                 220                 


Pro Xaa Pro Pro Pro Xaa Pro Val Pro Ser Pro His Pro Ala Pro Ala 
225                 230                 235                 240 


Leu Gly Ala Ala Gly Leu Pro Gly Pro Gly Ser Ala Leu Lys Gly Leu 
                245                 250                 255     


Gly Ala Ala His Pro Asp Leu Arg Ala Ser Gly Gly Ser Gly Ala Gly 
            260                 265                 270         


Lys Ala Lys Lys Ser Val Asp Lys Asn Ser Asn Glu Tyr Arg Val Arg 
        275                 280                 285             


Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser Arg Asp Lys Ala Lys 
    290                 295                 300                 


Gln Arg Asn Val Glu Xaa Gln Gln Lys Val Leu Glu Leu Xaa Ser Asp 
305                 310                 315                 320 


Asn Asp Arg Leu Arg Lys Arg Val Glu Gln Leu Ser Arg Glu Leu Asp 
                325                 330                 335     


Xaa Leu Arg Gly Ile Phe Arg Gln Leu Pro Glu Ser Ser Leu Val Lys 
            340                 345                 350         


Ala Met Gly Asn Cys Ala 
        355             


<210> 5833
<211> 345
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<400> 5833
Met Gln Arg Leu Val Ala Trp Asp Pro Ala Cys Leu Pro Leu Pro Pro 
1               5                   10                  15      


Pro Pro Pro Ala Phe Lys Ser Met Glu Val Ala Asn Phe Tyr Tyr Glu 
            20                  25                  30          


Ala Asp Cys Leu Ala Ala Ala Tyr Gly Gly Lys Ala Ala Pro Ala Ala 
        35                  40                  45              


Pro Pro Ala Ala Arg Pro Gly Pro Arg Pro Pro Ala Gly Glu Leu Gly 
    50                  55                  60                  


Ser Ile Gly Asp His Glu Arg Ala Ile Asp Phe Ser Pro Tyr Leu Glu 
65                  70                  75                  80  


Pro Leu Gly Ala Pro Gln Ala Pro Ala Pro Ala Xaa Ala Xaa Asp Xaa 
                85                  90                  95      


Phe Glu Ala Ala Pro Pro Ala Pro Ala Pro Ala Pro Ala Ser Ser Gly 
            100                 105                 110         


Gln His His Asp Phe Leu Ser Asp Leu Phe Ser Asp Asp Tyr Gly Gly 
        115                 120                 125             


Lys Asn Cys Lys Lys Pro Ala Glu Tyr Gly Tyr Val Ser Leu Gly Arg 
    130                 135                 140                 


Leu Gly Ala Ala Lys Gly Ala Leu His Pro Gly Cys Phe Ala Pro Leu 
145                 150                 155                 160 


His Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Glu Leu Lys Ala Glu 
                165                 170                 175     


Pro Gly Phe Glu Pro Ala Asp Cys Lys Arg Lys Glu Glu Ala Gly Ala 
            180                 185                 190         


Pro Gly Gly Gly Ala Gly Met Ala Ala Gly Phe Pro Tyr Ala Leu Arg 
        195                 200                 205             


Ala Tyr Leu Gly Tyr Gln Ala Val Pro Ser Gly Ser Ser Gly Ser Leu 
    210                 215                 220                 


Ser Xaa Ser Ser Ser Ser Ser Pro Pro Gly Xaa Pro Ser Pro Ala Asp 
225                 230                 235                 240 


Ala Lys Ala Pro Pro Xaa Ala Cys Tyr Ala Gly Ala Ala Pro Ala Pro 
                245                 250                 255     


Ser Gln Val Lys Ser Lys Ala Lys Lys Xaa Val Asp Lys His Ser Asp 
            260                 265                 270         


Glu Tyr Lys Ile Arg Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser 
        275                 280                 285             


Arg Asp Lys Ala Lys Met Arg Asn Leu Glu Xaa Gln His Lys Val Leu 
    290                 295                 300                 


Glu Leu Xaa Ala Glu Asn Glu Arg Leu Gln Lys Lys Val Glu Gln Leu 
305                 310                 315                 320 


Ser Arg Glu Leu Ser Xaa Leu Arg Asn Leu Phe Lys Gln Leu Pro Glu 
                325                 330                 335     


Pro Leu Leu Ala Ser Ser Gly His Cys 
            340                 345 


<210> 5834
<211> 269
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<400> 5834
Met Ser Ala Ala Leu Phe Ser Leu Asp Gly Pro Ala Arg Gly Ala Pro 
1               5                   10                  15      


Trp Pro Ala Glu Pro Ala Pro Phe Tyr Glu Pro Gly Arg Ala Gly Lys 
            20                  25                  30          


Pro Gly Arg Gly Ala Glu Pro Gly Ala Leu Gly Glu Pro Gly Ala Ala 
        35                  40                  45              


Ala Pro Ala Met Tyr Asp Asp Glu Ser Ala Ile Asp Phe Ser Ala Tyr 
    50                  55                  60                  


Ile Asp Ser Met Ala Ala Val Pro Xaa Leu Glu Leu Cys His Asp Glu 
65                  70                  75                  80  


Leu Phe Ala Asp Leu Phe Asn Ser Asn His Lys Ala Gly Gly Ala Gly 
                85                  90                  95      


Pro Leu Glu Leu Leu Pro Gly Gly Pro Ala Arg Pro Leu Gly Pro Gly 
            100                 105                 110         


Pro Ala Ala Pro Arg Leu Leu Lys Arg Glu Pro Asp Trp Gly Asp Gly 
        115                 120                 125             


Asp Ala Pro Gly Ser Leu Leu Pro Ala Gln Val Ala Ala Cys Ala Gln 
    130                 135                 140                 


Xaa Val Val Ser Leu Ala Ala Ala Gly Gln Pro Xaa Pro Pro Xaa Ser 
145                 150                 155                 160 


Pro Glu Pro Pro Arg Ser Ser Pro Arg Gln Xaa Pro Ala Pro Gly Pro 
                165                 170                 175     


Ala Arg Glu Lys Ser Ala Gly Lys Arg Gly Pro Asp Arg Gly Ser Pro 
            180                 185                 190         


Glu Tyr Arg Gln Arg Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser 
        195                 200                 205             


Arg Asp Lys Ala Lys Arg Arg Asn Gln Glu Met Gln Gln Lys Leu Val 
    210                 215                 220                 


Glu Leu Ser Ala Glu Asn Glu Lys Leu His Gln Arg Val Glu Gln Leu 
225                 230                 235                 240 


Xaa Arg Asp Leu Ala Gly Leu Arg Gln Phe Phe Lys Gln Leu Pro Ser 
                245                 250                 255     


Pro Pro Phe Leu Pro Ala Ala Gly Xaa Ala Asp Cys Arg 
            260                 265                 


<210> 5835
<211> 281
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<400> 5835
Met Ser His Gly Xaa Tyr Tyr Glu Cys Glu Pro Arg Gly Gly Gln Gln 
1               5                   10                  15      


Pro Leu Glu Phe Ser Gly Gly Arg Ala Gly Pro Gly Glu Leu Gly Asp 
            20                  25                  30          


Met Cys Glu His Glu Ala Ser Ile Asp Leu Ser Ala Tyr Ile Glu Ser 
        35                  40                  45              


Gly Glu Glu Gln Leu Leu Ser Asp Leu Phe Ala Val Lys Pro Ala Pro 
    50                  55                  60                  


Glu Ala Arg Gly Leu Lys Gly Pro Gly Xaa Pro Ala Phe Pro His Tyr 
65                  70                  75                  80  


Leu Pro Pro Asp Pro Arg Pro Phe Ala Tyr Pro Pro His Xaa Phe Gly 
                85                  90                  95      


Pro Asp Arg Lys Ala Leu Gly Pro Gly Ile Tyr Ser Ser Pro Gly Ser 
            100                 105                 110         


Tyr Asp Pro Arg Ala Val Ala Val Lys Glu Glu Pro Arg Gly Pro Glu 
        115                 120                 125             


Gly Ser Arg Ala Ala Ser Arg Gly Ser Tyr Asn Pro Leu Gln Tyr Gln 
    130                 135                 140                 


Val Ala His Cys Gly Gln Xaa Ala Met His Leu Pro Pro Xaa Leu Ala 
145                 150                 155                 160 


Ala Pro Gly Gln Pro Leu Arg Val Leu Lys Ala Pro Leu Ala Xaa Ala 
                165                 170                 175     


Ala Pro Pro Cys Ser Pro Leu Leu Lys Ala Pro Ser Pro Ala Gly Pro 
            180                 185                 190         


Leu His Lys Gly Lys Lys Ala Val Asn Lys Asp Ser Leu Glu Tyr Arg 
        195                 200                 205             


Leu Arg Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser Arg Asp Lys 
    210                 215                 220                 


Ala Lys Arg Arg Ile Leu Glu Xaa Gln Gln Lys Val Leu Glu Tyr Met 
225                 230                 235                 240 


Ala Glu Asn Glu Arg Leu Arg Ser Arg Val Glu Gln Leu Xaa Gln Glu 
                245                 250                 255     


Leu Asp Xaa Leu Arg Asn Leu Phe Arg Gln Ile Pro Glu Ala Ala Asn 
            260                 265                 270         


Leu Ile Lys Gly Val Gly Gly Cys Ser 
        275                 280     


<210> 5836
<211> 150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(142)
<223> Selenocysteine

<400> 5836
Met Ser Lys Ile Ser Gln Gln Asn Ser Xaa Pro Gly Val Asn Gly Ile 
1               5                   10                  15      


Ser Val Ile His Xaa Gln Ala His Ala Ser Gly Leu Gln Gln Val Pro 
            20                  25                  30          


Gln Leu Val Pro Ala Gly Pro Gly Gly Gly Gly Lys Ala Val Ala Pro 
        35                  40                  45              


Ser Lys Gln Ser Lys Lys Ser Ser Pro Met Asp Arg Asn Ser Asp Glu 
    50                  55                  60                  


Tyr Arg Gln Arg Arg Glu Arg Asn Asn Met Ala Val Lys Lys Ser Arg 
65                  70                  75                  80  


Leu Lys Ser Lys Gln Lys Ala Gln Asp Xaa Leu Gln Arg Val Asn Gln 
                85                  90                  95      


Leu Lys Glu Glu Asn Glu Arg Leu Glu Ala Lys Ile Lys Leu Leu Xaa 
            100                 105                 110         


Lys Glu Leu Ser Val Leu Lys Asp Leu Phe Leu Glu His Ala His Asn 
        115                 120                 125             


Leu Ala Asp Asn Val Gln Ser Ile Ser Xaa Glu Asn Xaa Xaa Ala Asp 
    130                 135                 140                 


Gly Asp Asn Ala Gly Gln 
145                 150 


<210> 5837
<211> 1484
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (996)..(996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1007)..(1007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1106)..(1106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1120)..(1120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1277)..(1277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1280)..(1280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1326)..(1326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1365)..(1365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1398)..(1398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1430)..(1430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1461)..(1461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1463)..(1463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1466)..(1466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1478)..(1478)
<223> Selenocysteine

<400> 5837
Met Cys Pro Glu Glu Gly Gly Ala Ala Gly Leu Gly Glu Leu Arg Ser 
1               5                   10                  15      


Trp Trp Glu Val Pro Ala Ile Ala His Phe Cys Ser Leu Phe Arg Xaa 
            20                  25                  30          


Ala Phe Arg Leu Pro Asp Phe Glu Ile Glu Glu Leu Glu Ala Ala Leu 
        35                  40                  45              


His Arg Asp Asp Val Glu Phe Ile Ser Asp Leu Ile Ala Cys Leu Leu 
    50                  55                  60                  


Gln Gly Cys Tyr Gln Arg Arg Asp Ile Xaa Pro Gln Xaa Phe His Ser 
65                  70                  75                  80  


Tyr Leu Glu Asp Ile Ile Asn Tyr Arg Trp Glu Leu Glu Glu Gly Lys 
                85                  90                  95      


Pro Asn Pro Leu Arg Glu Ala Ser Phe Gln Asp Leu Pro Leu Arg Xaa 
            100                 105                 110         


Arg Val Glu Ile Leu His Arg Leu Cys Asp Tyr Arg Leu Asp Ala Asp 
        115                 120                 125             


Asp Val Phe Asp Leu Leu Lys Gly Leu Asp Ala Asp Ser Leu Arg Val 
    130                 135                 140                 


Glu Pro Leu Gly Glu Asp Asn Ser Gly Ala Leu Tyr Trp Tyr Phe Tyr 
145                 150                 155                 160 


Gly Xaa Arg Met Tyr Lys Glu Asp Pro Val Gln Gly Lys Ser Asn Gly 
                165                 170                 175     


Glu Leu Ser Leu Ser Arg Glu Ser Glu Gly Gln Lys Asn Val Ser Ser 
            180                 185                 190         


Ile Pro Gly Lys Xaa Gly Lys Arg Arg Gly Arg Pro Pro Lys Arg Lys 
        195                 200                 205             


Lys Leu Gln Glu Glu Ile Leu Leu Ser Glu Lys Gln Glu Glu Asn Ser 
    210                 215                 220                 


Leu Ala Ser Glu Pro Gln Xaa Arg His Gly Ser Gln Gly Pro Gly Gln 
225                 230                 235                 240 


Gly Xaa Trp Trp Leu Leu Cys Gln Xaa Glu Glu Glu Trp Arg Gln Val 
                245                 250                 255     


Xaa Glu Ser Phe Arg Glu Arg Xaa Ser Leu Arg Glu Arg Gln Leu Tyr 
            260                 265                 270         


Lys Leu Leu Ser Glu Asp Phe Leu Pro Glu Ile Cys Asn Met Ile Ala 
        275                 280                 285             


Gln Lys Gly Lys Arg Pro Gln Arg Xaa Lys Ala Glu Leu His Pro Arg 
    290                 295                 300                 


Trp Met Ser Asp His Leu Ser Ile Lys Pro Val Lys Gln Glu Glu Xaa 
305                 310                 315                 320 


Pro Val Leu Xaa Arg Ile Glu Lys Gln Lys Arg Lys Glu Glu Glu Glu 
                325                 330                 335     


Glu Arg Gln Ile Leu Leu Ala Val Gln Lys Lys Glu Gln Glu Gln Met 
            340                 345                 350         


Leu Lys Glu Glu Arg Lys Arg Glu Leu Glu Glu Lys Val Lys Ala Val 
        355                 360                 365             


Glu Gly Met Cys Ser Val Arg Val Val Trp Arg Gly Ala Cys Leu Ser 
    370                 375                 380                 


Xaa Ser Arg Pro Val Asp Arg Ala Lys Arg Arg Lys Leu Arg Glu Glu 
385                 390                 395                 400 


Arg Ala Trp Leu Leu Ala Gln Gly Lys Glu Leu Pro Pro Glu Leu Ser 
                405                 410                 415     


His Leu Asp Pro Asn Ser Pro Met Arg Glu Glu Lys Lys Xaa Lys Asp 
            420                 425                 430         


Leu Phe Glu Leu Asp Asp Asp Phe Xaa Ala Met Tyr Lys Val Leu Asp 
        435                 440                 445             


Val Val Lys Ala His Lys Asp Ser Trp Pro Phe Leu Glu Pro Val Asp 
    450                 455                 460                 


Glu Ser Tyr Ala Pro Asn Tyr Tyr Gln Ile Ile Lys Ala Pro Met Asp 
465                 470                 475                 480 


Ile Ser Ser Met Glu Lys Lys Leu Asn Gly Gly Leu Tyr Cys Xaa Lys 
                485                 490                 495     


Glu Glu Phe Val Asn Asp Met Lys Xaa Met Phe Arg Asn Cys Arg Lys 
            500                 505                 510         


Tyr Asn Gly Glu Ser Ser Glu Tyr Xaa Lys Met Ser Asp Asn Leu Glu 
        515                 520                 525             


Arg Cys Phe His Arg Ala Met Met Lys His Phe Pro Gly Glu Asp Gly 
    530                 535                 540                 


Asp Xaa Asp Glu Glu Phe Trp Ile Arg Glu Asp Glu Lys Arg Glu Lys 
545                 550                 555                 560 


Arg Arg Ser Arg Ala Gly Arg Ser Gly Gly Ser His Val Trp Xaa Arg 
                565                 570                 575     


Ser Arg Asp Pro Glu Gly Ser Ser Arg Lys Gln Gln Pro Met Glu Asn 
            580                 585                 590         


Gly Gly Lys Ser Leu Pro Pro Xaa Arg Arg Ala Pro Ser Ser Gly Asp 
        595                 600                 605             


Asp Gln Ser Ser Ser Ser Xaa Gln Pro Pro Arg Glu Val Gly Xaa Ser 
    610                 615                 620                 


Asn Gly Arg Gly Phe Ser His Pro Leu His Cys Gly Gly Xaa Pro Ser 
625                 630                 635                 640 


Gln Ala Pro Phe Leu Asn Gln Met Arg Pro Ala Val Pro Gly Xaa Phe 
                645                 650                 655     


Gly Pro Leu Arg Gly Ser Asp Pro Ala Xaa Leu Tyr Gly Ser Ser Gly 
            660                 665                 670         


Val Pro Glu Pro His Pro Gly Glu Pro Val Gln Gln Arg Gln Pro Phe 
        675                 680                 685             


Xaa Met Gln Pro Pro Val Gly Ile Asn Ser Leu Arg Gly Pro Arg Leu 
    690                 695                 700                 


Gly Xaa Pro Glu Glu Lys Gln Met Cys Gly Gly Leu Xaa His Leu Ser 
705                 710                 715                 720 


Asn Met Gly Pro His Pro Gly Ser Leu Gln Leu Gly Gln Ile Ser Gly 
                725                 730                 735     


Pro Ser Gln Asp Gly Ser Met Tyr Ala Pro Ala Gln Phe Gln Pro Gly 
            740                 745                 750         


Phe Ile Pro Pro Arg His Gly Gly Ala Pro Ala Arg Pro Pro Asp Phe 
        755                 760                 765             


Pro Glu Ser Ser Glu Ile Pro Pro Ser His Met Tyr Arg Ser Tyr Lys 
    770                 775                 780                 


Tyr Leu Asn Arg Val His Ser Ala Val Trp Asn Gly Asn His Gly Ala 
785                 790                 795                 800 


Xaa Asn Gln Gly Pro Leu Gly Pro Asp Glu Lys Pro His Leu Gly Pro 
                805                 810                 815     


Gly Pro Ser His Gln Pro Arg Xaa Leu Gly His Val Met Asp Ser Arg 
            820                 825                 830         


Val Met Arg Pro Pro Val Pro Pro Asn Gln Trp Xaa Glu Gln Ser Gly 
        835                 840                 845             


Phe Leu Pro His Gly Val Pro Ser Ser Gly Tyr Met Arg Pro Pro Cys 
    850                 855                 860                 


Lys Ser Ala Gly His Arg Leu Gln Pro Pro Pro Val Pro Ala Pro Ser 
865                 870                 875                 880 


Ser Leu Phe Gly Ala Pro Ala Gln Ala Leu Arg Gly Val Gln Gly Gly 
                885                 890                 895     


Asp Ser Met Met Asp Ser Pro Glu Met Ile Ala Met Gln Gln Leu Ser 
            900                 905                 910         


Ser Arg Val Cys Pro Pro Gly Val Pro Tyr His Pro His Gln Pro Ala 
        915                 920                 925             


His Pro Arg Leu Pro Gly Pro Phe Pro Gln Val Ala His Pro Met Ser 
    930                 935                 940                 


Val Xaa Val Ser Ala Pro Lys Pro Ala Leu Gly Asn Pro Gly Arg Ala 
945                 950                 955                 960 


Pro Glu Asn Ser Glu Ala Gln Glu Pro Glu Asn Asp Gln Ala Glu Pro 
                965                 970                 975     


Leu Pro Gly Leu Glu Glu Lys Pro Pro Gly Val Gly Xaa Ser Glu Gly 
            980                 985                 990         


Val Tyr Leu Xaa Gln Leu Pro His  Pro Xaa Pro Pro Leu  Gln Xaa Asp 
        995                 1000                 1005             


Cys Xaa  Arg Gln Ser Ser Pro  Gln Glu Arg Glu Xaa  Val Gly Pro 
    1010                 1015                 1020             


Glu Leu  Lys Ser Ser Ser Ser  Glu Ser Ala Asp Asn  Cys Lys Ala 
    1025                 1030                 1035             


Met Lys  Gly Lys Asn Pro Trp  Pro Ser Asp Ser Ser  Tyr Pro Gly 
    1040                 1045                 1050             


Pro Ala  Ala Gln Gly Cys Val  Arg Asp Leu Ser Xaa  Val Ala Asp 
    1055                 1060                 1065             


Arg Gly  Ala Leu Ser Glu Asn  Gly Val Ile Gly Glu  Ala Ser Pro 
    1070                 1075                 1080             


Cys Gly  Ser Glu Gly Lys Gly  Leu Gly Ser Ser Gly  Ser Glu Lys 
    1085                 1090                 1095             


Leu Leu  Cys Pro Arg Gly Arg  Xaa Leu Gln Glu Xaa  Met Pro Cys 
    1100                 1105                 1110             


Xaa Gly  Gln Asn Ala Ala Xaa  Pro Pro Ser Xaa Asp  Pro Gly Leu 
    1115                 1120                 1125             


Xaa Gly  Gly Xaa Val Ser Gln  Phe Pro Pro Leu Tyr  Met Pro Gly 
    1130                 1135                 1140             


Leu Glu  Tyr Pro Asn Ser Ala  Ala His Tyr His Ile  Ser Pro Gly 
    1145                 1150                 1155             


Leu Gln  Gly Val Gly Pro Val  Met Gly Gly Lys Ser  Pro Ala Ser 
    1160                 1165                 1170             


His Pro  Gln His Phe Pro Pro  Arg Gly Phe Gln Ser  Asn His Pro 
    1175                 1180                 1185             


His Ser  Gly Gly Phe Pro Arg  Tyr Arg Pro Pro Gln  Gly Met Arg 
    1190                 1195                 1200             


Tyr Ser  Tyr His Pro Pro Pro  Gln Pro Ser Tyr His  His Tyr Gln 
    1205                 1210                 1215             


Arg Xaa  Pro Tyr Tyr Ala Cys  Pro Gln Ser Phe Ser  Asp Trp Gln 
    1220                 1225                 1230             


Arg Pro  Leu His Pro Gln Gly  Ser Pro Ser Gly Pro  Pro Ala Ser 
    1235                 1240                 1245             


Gln Pro  Pro Pro Pro Arg Ser  Leu Phe Ser Asp Lys  Asn Ala Met 
    1250                 1255                 1260             


Ala Ser  Leu Gln Gly Cys Glu  Xaa Leu Asn Ala Ala  Leu Xaa Ser 
    1265                 1270                 1275             


Pro Xaa  Arg Met Asp Ala Val  Ala Ala Lys Val Pro  Asn Asp Gly 
    1280                 1285                 1290             


Gln Asn  Pro Gly Pro Glu Glu  Glu Lys Leu Asp Glu  Ser Met Glu 
    1295                 1300                 1305             


Arg Pro  Glu Ser Pro Lys Glu  Phe Leu Asp Leu Asp  Asn His Asn 
    1310                 1315                 1320             


Ala Ala  Xaa Lys Arg Gln Ser  Ser Leu Ser Ala Ser  Glu Tyr Leu 
    1325                 1330                 1335             


Tyr Gly  Xaa Pro Pro Pro Leu  Ser Ser Gly Met Gly  Phe Gly Ser 
    1340                 1345                 1350             


Ser Ala  Phe Pro Pro His Ser  Val Met Leu Gln Xaa  Gly Pro Pro 
    1355                 1360                 1365             


Tyr Xaa  Pro Gln Arg Pro Ala  Ser His Phe Gln Pro  Arg Ala Tyr 
    1370                 1375                 1380             


Ser Ser  Pro Val Ala Ala Leu  Pro Pro His His Pro  Gly Ala Xaa 
    1385                 1390                 1395             


Gln Pro  Asn Gly Leu Ser Gln  Glu Gly Pro Ile Tyr  Arg Cys Gln 
    1400                 1405                 1410             


Glu Glu  Gly Leu Gly His Phe  Gln Ala Val Met Met  Glu Gln Ile 
    1415                 1420                 1425             


Gly Xaa  Arg Ser Gly Ile Arg  Gly Pro Phe Gln Glu  Met Tyr Arg 
    1430                 1435                 1440             


Pro Ser  Gly Met Gln Met His  Pro Val Gln Ser Gln  Ala Ser Phe 
    1445                 1450                 1455             


Pro Lys  Xaa Pro Xaa Ala Ala  Xaa Ser Gln Glu Glu  Val Pro Pro 
    1460                 1465                 1470             


His Lys  Pro Pro Xaa Leu Pro  Leu Asp Gln Ser 
    1475                 1480                 


<210> 5838
<211> 1442
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1235)..(1235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1238)..(1238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1299)..(1299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1323)..(1323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1328)..(1328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1356)..(1356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1388)..(1388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1419)..(1419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1421)..(1421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1424)..(1424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1436)..(1436)
<223> Selenocysteine

<400> 5838
Met Pro Phe Lys Ile Gln Trp Phe Phe Lys Ala Val Ala Asp Gly Leu 
1               5                   10                  15      


Ser Leu Glu Lys Glu Leu Glu Ala Ala Leu His Arg Asp Asp Val Glu 
            20                  25                  30          


Phe Ile Ser Asp Leu Ile Ala Cys Leu Leu Gln Gly Cys Tyr Gln Arg 
        35                  40                  45              


Arg Asp Ile Xaa Pro Gln Xaa Phe His Ser Tyr Leu Glu Asp Ile Ile 
    50                  55                  60                  


Asn Tyr Arg Trp Glu Leu Glu Glu Gly Lys Pro Asn Pro Leu Arg Glu 
65                  70                  75                  80  


Ala Ser Phe Gln Asp Leu Pro Leu Arg Xaa Arg Val Glu Ile Leu His 
                85                  90                  95      


Arg Leu Cys Asp Tyr Arg Leu Asp Ala Asp Asp Val Phe Asp Leu Leu 
            100                 105                 110         


Lys Gly Leu Asp Ala Asp Ser Leu Arg Val Glu Pro Leu Gly Glu Asp 
        115                 120                 125             


Asn Ser Gly Ala Leu Tyr Trp Tyr Phe Tyr Gly Xaa Arg Met Tyr Lys 
    130                 135                 140                 


Glu Asp Pro Val Gln Gly Lys Ser Asn Gly Glu Leu Ser Leu Ser Arg 
145                 150                 155                 160 


Glu Ser Glu Gly Gln Lys Asn Val Ser Ser Ile Pro Gly Lys Xaa Gly 
                165                 170                 175     


Lys Arg Arg Gly Arg Pro Pro Lys Arg Lys Lys Leu Gln Glu Glu Ile 
            180                 185                 190         


Leu Leu Ser Glu Lys Gln Glu Glu Asn Ser Leu Ala Ser Glu Pro Gln 
        195                 200                 205             


Xaa Arg His Gly Ser Gln Gly Pro Gly Gln Gly Xaa Trp Trp Leu Leu 
    210                 215                 220                 


Cys Gln Xaa Glu Glu Glu Trp Arg Gln Val Xaa Glu Ser Phe Arg Glu 
225                 230                 235                 240 


Arg Xaa Ser Leu Arg Glu Arg Gln Leu Tyr Lys Leu Leu Ser Glu Asp 
                245                 250                 255     


Phe Leu Pro Glu Ile Cys Asn Met Ile Ala Gln Lys Gly Lys Arg Pro 
            260                 265                 270         


Gln Arg Xaa Lys Ala Glu Leu His Pro Arg Trp Met Ser Asp His Leu 
        275                 280                 285             


Ser Ile Lys Pro Val Lys Gln Glu Glu Xaa Pro Val Leu Xaa Arg Ile 
    290                 295                 300                 


Glu Lys Gln Lys Arg Lys Glu Glu Glu Glu Glu Arg Gln Ile Leu Leu 
305                 310                 315                 320 


Ala Val Gln Lys Lys Glu Gln Glu Gln Met Leu Lys Glu Glu Arg Lys 
                325                 330                 335     


Arg Glu Leu Glu Glu Lys Val Lys Ala Val Glu Asp Arg Ala Lys Arg 
            340                 345                 350         


Arg Lys Leu Arg Glu Glu Arg Ala Trp Leu Leu Ala Gln Gly Lys Glu 
        355                 360                 365             


Leu Pro Pro Glu Leu Ser His Leu Asp Pro Asn Ser Pro Met Arg Glu 
    370                 375                 380                 


Glu Lys Lys Xaa Lys Asp Leu Phe Glu Leu Asp Asp Asp Phe Xaa Ala 
385                 390                 395                 400 


Met Tyr Lys Val Leu Asp Val Val Lys Ala His Lys Asp Ser Trp Pro 
                405                 410                 415     


Phe Leu Glu Pro Val Asp Glu Ser Tyr Ala Pro Asn Tyr Tyr Gln Ile 
            420                 425                 430         


Ile Lys Ala Pro Met Asp Ile Ser Ser Met Glu Lys Lys Leu Asn Gly 
        435                 440                 445             


Gly Leu Tyr Cys Xaa Lys Glu Glu Phe Val Asn Asp Met Lys Xaa Met 
    450                 455                 460                 


Phe Arg Asn Cys Arg Lys Tyr Asn Gly Glu Ser Ser Glu Tyr Xaa Lys 
465                 470                 475                 480 


Met Ser Asp Asn Leu Glu Arg Cys Phe His Arg Ala Met Met Lys His 
                485                 490                 495     


Phe Pro Gly Glu Asp Gly Asp Xaa Asp Glu Glu Phe Trp Ile Arg Glu 
            500                 505                 510         


Asp Glu Lys Arg Glu Lys Arg Arg Ser Arg Ala Gly Arg Ser Gly Gly 
        515                 520                 525             


Ser His Val Trp Xaa Arg Ser Arg Asp Pro Glu Gly Ser Ser Arg Lys 
    530                 535                 540                 


Gln Gln Pro Met Glu Asn Gly Gly Lys Ser Leu Pro Pro Xaa Arg Arg 
545                 550                 555                 560 


Ala Pro Ser Ser Gly Asp Asp Gln Ser Ser Ser Ser Xaa Gln Pro Pro 
                565                 570                 575     


Arg Glu Val Gly Xaa Ser Asn Gly Arg Gly Phe Ser His Pro Leu His 
            580                 585                 590         


Cys Gly Gly Xaa Pro Ser Gln Ala Pro Phe Leu Asn Gln Met Arg Pro 
        595                 600                 605             


Ala Val Pro Gly Xaa Phe Gly Pro Leu Arg Gly Ser Asp Pro Ala Xaa 
    610                 615                 620                 


Leu Tyr Gly Ser Ser Gly Val Pro Glu Pro His Pro Gly Glu Pro Val 
625                 630                 635                 640 


Gln Gln Arg Gln Pro Phe Xaa Met Gln Pro Pro Val Gly Ile Asn Ser 
                645                 650                 655     


Leu Arg Gly Pro Arg Leu Gly Xaa Pro Glu Glu Lys Gln Met Cys Gly 
            660                 665                 670         


Gly Leu Xaa His Leu Ser Asn Met Gly Pro His Pro Gly Ser Leu Gln 
        675                 680                 685             


Leu Gly Gln Ile Ser Gly Pro Ser Gln Asp Gly Ser Met Tyr Ala Pro 
    690                 695                 700                 


Ala Gln Phe Gln Pro Gly Phe Ile Pro Pro Arg His Gly Gly Ala Pro 
705                 710                 715                 720 


Ala Arg Pro Pro Asp Phe Pro Glu Ser Ser Glu Ile Pro Pro Ser His 
                725                 730                 735     


Met Tyr Arg Ser Tyr Lys Tyr Leu Asn Arg Val His Ser Ala Val Trp 
            740                 745                 750         


Asn Gly Asn His Gly Ala Xaa Asn Gln Gly Pro Leu Gly Pro Asp Glu 
        755                 760                 765             


Lys Pro His Leu Gly Pro Gly Pro Ser His Gln Pro Arg Xaa Leu Gly 
    770                 775                 780                 


His Val Met Asp Ser Arg Val Met Arg Pro Pro Val Pro Pro Asn Gln 
785                 790                 795                 800 


Trp Xaa Glu Gln Ser Gly Phe Leu Pro His Gly Val Pro Ser Ser Gly 
                805                 810                 815     


Tyr Met Arg Pro Pro Cys Lys Ser Ala Gly His Arg Leu Gln Pro Pro 
            820                 825                 830         


Pro Val Pro Ala Pro Ser Ser Leu Phe Gly Ala Pro Ala Gln Ala Leu 
        835                 840                 845             


Arg Gly Val Gln Gly Gly Asp Ser Met Met Asp Ser Pro Glu Met Ile 
    850                 855                 860                 


Ala Met Gln Gln Leu Ser Ser Arg Val Cys Pro Pro Gly Val Pro Tyr 
865                 870                 875                 880 


His Pro His Gln Pro Ala His Pro Arg Leu Pro Gly Pro Phe Pro Gln 
                885                 890                 895     


Val Ala His Pro Met Ser Val Xaa Val Ser Ala Pro Lys Pro Ala Leu 
            900                 905                 910         


Gly Asn Pro Gly Arg Ala Pro Glu Asn Ser Glu Ala Gln Glu Pro Glu 
        915                 920                 925             


Asn Asp Gln Ala Glu Pro Leu Pro Gly Leu Glu Glu Lys Pro Pro Gly 
    930                 935                 940                 


Val Gly Xaa Ser Glu Gly Val Tyr Leu Xaa Gln Leu Pro His Pro Xaa 
945                 950                 955                 960 


Pro Pro Leu Gln Xaa Asp Cys Xaa Arg Gln Ser Ser Pro Gln Glu Arg 
                965                 970                 975     


Glu Xaa Val Gly Pro Glu Leu Lys Ser Ser Ser Ser Glu Ser Ala Asp 
            980                 985                 990         


Asn Cys Lys Ala Met Lys Gly Lys  Asn Pro Trp Pro Ser  Asp Ser Ser 
        995                 1000                 1005             


Tyr Pro  Gly Pro Ala Ala Gln  Gly Cys Val Arg Asp  Leu Ser Xaa 
    1010                 1015                 1020             


Val Ala  Asp Arg Gly Ala Leu  Ser Glu Asn Gly Val  Ile Gly Glu 
    1025                 1030                 1035             


Ala Ser  Pro Cys Gly Ser Glu  Gly Lys Gly Leu Gly  Ser Ser Gly 
    1040                 1045                 1050             


Ser Glu  Lys Leu Leu Cys Pro  Arg Gly Arg Xaa Leu  Gln Glu Xaa 
    1055                 1060                 1065             


Met Pro  Cys Xaa Gly Gln Asn  Ala Ala Xaa Pro Pro  Ser Xaa Asp 
    1070                 1075                 1080             


Pro Gly  Leu Xaa Gly Gly Xaa  Val Ser Gln Phe Pro  Pro Leu Tyr 
    1085                 1090                 1095             


Met Pro  Gly Leu Glu Tyr Pro  Asn Ser Ala Ala His  Tyr His Ile 
    1100                 1105                 1110             


Ser Pro  Gly Leu Gln Gly Val  Gly Pro Val Met Gly  Gly Lys Ser 
    1115                 1120                 1125             


Pro Ala  Ser His Pro Gln His  Phe Pro Pro Arg Gly  Phe Gln Ser 
    1130                 1135                 1140             


Asn His  Pro His Ser Gly Gly  Phe Pro Arg Tyr Arg  Pro Pro Gln 
    1145                 1150                 1155             


Gly Met  Arg Tyr Ser Tyr His  Pro Pro Pro Gln Pro  Ser Tyr His 
    1160                 1165                 1170             


His Tyr  Gln Arg Xaa Pro Tyr  Tyr Ala Cys Pro Gln  Ser Phe Ser 
    1175                 1180                 1185             


Asp Trp  Gln Arg Pro Leu His  Pro Gln Gly Ser Pro  Ser Gly Pro 
    1190                 1195                 1200             


Pro Ala  Ser Gln Pro Pro Pro  Pro Arg Ser Leu Phe  Ser Asp Lys 
    1205                 1210                 1215             


Asn Ala  Met Ala Ser Leu Gln  Gly Cys Glu Xaa Leu  Asn Ala Ala 
    1220                 1225                 1230             


Leu Xaa  Ser Pro Xaa Arg Met  Asp Ala Val Ala Ala  Lys Val Pro 
    1235                 1240                 1245             


Asn Asp  Gly Gln Asn Pro Gly  Pro Glu Glu Glu Lys  Leu Asp Glu 
    1250                 1255                 1260             


Ser Met  Glu Arg Pro Glu Ser  Pro Lys Glu Phe Leu  Asp Leu Asp 
    1265                 1270                 1275             


Asn His  Asn Ala Ala Xaa Lys  Arg Gln Ser Ser Leu  Ser Ala Ser 
    1280                 1285                 1290             


Glu Tyr  Leu Tyr Gly Xaa Pro  Pro Pro Leu Ser Ser  Gly Met Gly 
    1295                 1300                 1305             


Phe Gly  Ser Ser Ala Phe Pro  Pro His Ser Val Met  Leu Gln Xaa 
    1310                 1315                 1320             


Gly Pro  Pro Tyr Xaa Pro Gln  Arg Pro Ala Ser His  Phe Gln Pro 
    1325                 1330                 1335             


Arg Ala  Tyr Ser Ser Pro Val  Ala Ala Leu Pro Pro  His His Pro 
    1340                 1345                 1350             


Gly Ala  Xaa Gln Pro Asn Gly  Leu Ser Gln Glu Gly  Pro Ile Tyr 
    1355                 1360                 1365             


Arg Cys  Gln Glu Glu Gly Leu  Gly His Phe Gln Ala  Val Met Met 
    1370                 1375                 1380             


Glu Gln  Ile Gly Xaa Arg Ser  Gly Ile Arg Gly Pro  Phe Gln Glu 
    1385                 1390                 1395             


Met Tyr  Arg Pro Ser Gly Met  Gln Met His Pro Val  Gln Ser Gln 
    1400                 1405                 1410             


Ala Ser  Phe Pro Lys Xaa Pro  Xaa Ala Ala Xaa Ser  Gln Glu Glu 
    1415                 1420                 1425             


Val Pro  Pro His Lys Pro Pro  Xaa Leu Pro Leu Asp  Gln Ser 
    1430                 1435                 1440         


<210> 5839
<211> 1300
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1093)..(1093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1214)..(1214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1246)..(1246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1277)..(1277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1282)..(1282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1294)..(1294)
<223> Selenocysteine

<400> 5839
Met Tyr Lys Glu Asp Pro Val Gln Gly Lys Ser Asn Gly Glu Leu Ser 
1               5                   10                  15      


Leu Ser Arg Glu Ser Glu Gly Gln Lys Asn Val Ser Ser Ile Pro Gly 
            20                  25                  30          


Lys Xaa Gly Lys Arg Arg Gly Arg Pro Pro Lys Arg Lys Lys Leu Gln 
        35                  40                  45              


Glu Glu Ile Leu Leu Ser Glu Lys Gln Glu Glu Asn Ser Leu Ala Ser 
    50                  55                  60                  


Glu Pro Gln Xaa Arg His Gly Ser Gln Gly Pro Gly Gln Gly Xaa Trp 
65                  70                  75                  80  


Trp Leu Leu Cys Gln Xaa Glu Glu Glu Trp Arg Gln Val Xaa Glu Ser 
                85                  90                  95      


Phe Arg Glu Arg Xaa Ser Leu Arg Glu Arg Gln Leu Tyr Lys Leu Leu 
            100                 105                 110         


Ser Glu Asp Phe Leu Pro Glu Ile Cys Asn Met Ile Ala Gln Lys Gly 
        115                 120                 125             


Lys Arg Pro Gln Arg Xaa Lys Ala Glu Leu His Pro Arg Trp Met Ser 
    130                 135                 140                 


Asp His Leu Ser Ile Lys Pro Val Lys Gln Glu Glu Xaa Pro Val Leu 
145                 150                 155                 160 


Xaa Arg Ile Glu Lys Gln Lys Arg Lys Glu Glu Glu Glu Glu Arg Gln 
                165                 170                 175     


Ile Leu Leu Ala Val Gln Lys Lys Glu Gln Glu Gln Met Leu Lys Glu 
            180                 185                 190         


Glu Arg Lys Arg Glu Leu Glu Glu Lys Val Lys Ala Val Glu Asp Arg 
        195                 200                 205             


Ala Lys Arg Arg Lys Leu Arg Glu Glu Arg Ala Trp Leu Leu Ala Gln 
    210                 215                 220                 


Gly Lys Glu Leu Pro Pro Glu Leu Ser His Leu Asp Pro Asn Ser Pro 
225                 230                 235                 240 


Met Arg Glu Glu Lys Lys Xaa Lys Asp Leu Phe Glu Leu Asp Asp Asp 
                245                 250                 255     


Phe Xaa Ala Met Tyr Lys Val Leu Asp Val Val Lys Ala His Lys Asp 
            260                 265                 270         


Ser Trp Pro Phe Leu Glu Pro Val Asp Glu Ser Tyr Ala Pro Asn Tyr 
        275                 280                 285             


Tyr Gln Ile Ile Lys Ala Pro Met Asp Ile Ser Ser Met Glu Lys Lys 
    290                 295                 300                 


Leu Asn Gly Gly Leu Tyr Cys Xaa Lys Glu Glu Phe Val Asn Asp Met 
305                 310                 315                 320 


Lys Xaa Met Phe Arg Asn Cys Arg Lys Tyr Asn Gly Glu Ser Ser Glu 
                325                 330                 335     


Tyr Xaa Lys Met Ser Asp Asn Leu Glu Arg Cys Phe His Arg Ala Met 
            340                 345                 350         


Met Lys His Phe Pro Gly Glu Asp Gly Asp Xaa Asp Glu Glu Phe Trp 
        355                 360                 365             


Ile Arg Glu Asp Glu Lys Arg Glu Lys Arg Arg Ser Arg Ala Gly Arg 
    370                 375                 380                 


Ser Gly Gly Ser His Val Trp Xaa Arg Ser Arg Asp Pro Glu Gly Ser 
385                 390                 395                 400 


Ser Arg Lys Gln Gln Pro Met Glu Asn Gly Gly Lys Ser Leu Pro Pro 
                405                 410                 415     


Xaa Arg Arg Ala Pro Ser Ser Gly Asp Asp Gln Ser Ser Ser Ser Xaa 
            420                 425                 430         


Gln Pro Pro Arg Glu Val Gly Xaa Ser Asn Gly Arg Gly Phe Ser His 
        435                 440                 445             


Pro Leu His Cys Gly Gly Xaa Pro Ser Gln Ala Pro Phe Leu Asn Gln 
    450                 455                 460                 


Met Arg Pro Ala Val Pro Gly Xaa Phe Gly Pro Leu Arg Gly Ser Asp 
465                 470                 475                 480 


Pro Ala Xaa Leu Tyr Gly Ser Ser Gly Val Pro Glu Pro His Pro Gly 
                485                 490                 495     


Glu Pro Val Gln Gln Arg Gln Pro Phe Xaa Met Gln Pro Pro Val Gly 
            500                 505                 510         


Ile Asn Ser Leu Arg Gly Pro Arg Leu Gly Xaa Pro Glu Glu Lys Gln 
        515                 520                 525             


Met Cys Gly Gly Leu Xaa His Leu Ser Asn Met Gly Pro His Pro Gly 
    530                 535                 540                 


Ser Leu Gln Leu Gly Gln Ile Ser Gly Pro Ser Gln Asp Gly Ser Met 
545                 550                 555                 560 


Tyr Ala Pro Ala Gln Phe Gln Pro Gly Phe Ile Pro Pro Arg His Gly 
                565                 570                 575     


Gly Ala Pro Ala Arg Pro Pro Asp Phe Pro Glu Ser Ser Glu Ile Pro 
            580                 585                 590         


Pro Ser His Met Tyr Arg Ser Tyr Lys Tyr Leu Asn Arg Val His Ser 
        595                 600                 605             


Ala Val Trp Asn Gly Asn His Gly Ala Xaa Asn Gln Gly Pro Leu Gly 
    610                 615                 620                 


Pro Asp Glu Lys Pro His Leu Gly Pro Gly Pro Ser His Gln Pro Arg 
625                 630                 635                 640 


Xaa Leu Gly His Val Met Asp Ser Arg Val Met Arg Pro Pro Val Pro 
                645                 650                 655     


Pro Asn Gln Trp Xaa Glu Gln Ser Gly Phe Leu Pro His Gly Val Pro 
            660                 665                 670         


Ser Ser Gly Tyr Met Arg Pro Pro Cys Lys Ser Ala Gly His Arg Leu 
        675                 680                 685             


Gln Pro Pro Pro Val Pro Ala Pro Ser Ser Leu Phe Gly Ala Pro Ala 
    690                 695                 700                 


Gln Ala Leu Arg Gly Val Gln Gly Gly Asp Ser Met Met Asp Ser Pro 
705                 710                 715                 720 


Glu Met Ile Ala Met Gln Gln Leu Ser Ser Arg Val Cys Pro Pro Gly 
                725                 730                 735     


Val Pro Tyr His Pro His Gln Pro Ala His Pro Arg Leu Pro Gly Pro 
            740                 745                 750         


Phe Pro Gln Val Ala His Pro Met Ser Val Xaa Val Ser Ala Pro Lys 
        755                 760                 765             


Pro Ala Leu Gly Asn Pro Gly Arg Ala Pro Glu Asn Ser Glu Ala Gln 
    770                 775                 780                 


Glu Pro Glu Asn Asp Gln Glu Pro Leu Pro Gly Leu Glu Glu Lys Pro 
785                 790                 795                 800 


Pro Gly Val Gly Xaa Ser Glu Gly Val Tyr Leu Xaa Gln Leu Pro His 
                805                 810                 815     


Pro Xaa Pro Pro Leu Gln Xaa Asp Cys Xaa Arg Gln Ser Ser Pro Gln 
            820                 825                 830         


Glu Arg Glu Xaa Val Gly Pro Glu Leu Lys Ser Ser Ser Ser Glu Ser 
        835                 840                 845             


Ala Asp Asn Cys Lys Ala Met Lys Gly Lys Asn Pro Trp Pro Ser Asp 
    850                 855                 860                 


Ser Ser Tyr Pro Gly Pro Ala Ala Gln Gly Cys Val Arg Asp Leu Ser 
865                 870                 875                 880 


Xaa Val Ala Asp Arg Gly Ala Leu Ser Glu Asn Gly Val Ile Gly Glu 
                885                 890                 895     


Ala Ser Pro Cys Gly Ser Glu Gly Lys Gly Leu Gly Ser Ser Gly Ser 
            900                 905                 910         


Glu Lys Leu Leu Cys Pro Arg Gly Arg Xaa Leu Gln Glu Xaa Met Pro 
        915                 920                 925             


Cys Xaa Gly Gln Asn Ala Ala Xaa Pro Pro Ser Xaa Asp Pro Gly Leu 
    930                 935                 940                 


Xaa Gly Gly Xaa Val Ser Gln Phe Pro Pro Leu Tyr Met Pro Gly Leu 
945                 950                 955                 960 


Glu Tyr Pro Asn Ser Ala Ala His Tyr His Ile Ser Pro Gly Leu Gln 
                965                 970                 975     


Gly Val Gly Pro Val Met Gly Gly Lys Ser Pro Ala Ser His Pro Gln 
            980                 985                 990         


His Phe Pro Pro Arg Gly Phe Gln  Ser Asn His Pro His  Ser Gly Gly 
        995                 1000                 1005             


Phe Pro  Arg Tyr Arg Pro Pro  Gln Gly Met Arg Tyr  Ser Tyr His 
    1010                 1015                 1020             


Pro Pro  Pro Gln Pro Ser Tyr  His His Tyr Gln Arg  Xaa Pro Tyr 
    1025                 1030                 1035             


Tyr Ala  Cys Pro Gln Ser Phe  Ser Asp Trp Gln Arg  Pro Leu His 
    1040                 1045                 1050             


Pro Gln  Gly Ser Pro Ser Gly  Pro Pro Ala Ser Gln  Pro Pro Pro 
    1055                 1060                 1065             


Pro Arg  Ser Leu Phe Ser Asp  Lys Asn Ala Met Ala  Ser Leu Gln 
    1070                 1075                 1080             


Gly Cys  Glu Xaa Leu Asn Ala  Ala Leu Xaa Ser Pro  Xaa Arg Met 
    1085                 1090                 1095             


Asp Ala  Val Ala Ala Lys Val  Pro Asn Asp Gly Gln  Asn Pro Gly 
    1100                 1105                 1110             


Pro Glu  Glu Glu Lys Leu Asp  Glu Ser Met Glu Arg  Pro Glu Ser 
    1115                 1120                 1125             


Pro Lys  Glu Phe Leu Asp Leu  Asp Asn His Asn Ala  Ala Xaa Lys 
    1130                 1135                 1140             


Arg Gln  Ser Ser Leu Ser Ala  Ser Glu Tyr Leu Tyr  Gly Xaa Pro 
    1145                 1150                 1155             


Pro Pro  Leu Ser Ser Gly Met  Gly Phe Gly Ser Ser  Ala Phe Pro 
    1160                 1165                 1170             


Pro His  Ser Val Met Leu Gln  Xaa Gly Pro Pro Tyr  Xaa Pro Gln 
    1175                 1180                 1185             


Arg Pro  Ala Ser His Phe Gln  Pro Arg Ala Tyr Ser  Ser Pro Val 
    1190                 1195                 1200             


Ala Ala  Leu Pro Pro His His  Pro Gly Ala Xaa Gln  Pro Asn Gly 
    1205                 1210                 1215             


Leu Ser  Gln Glu Gly Pro Ile  Tyr Arg Cys Gln Glu  Glu Gly Leu 
    1220                 1225                 1230             


Gly His  Phe Gln Ala Val Met  Met Glu Gln Ile Gly  Xaa Arg Ser 
    1235                 1240                 1245             


Gly Ile  Arg Gly Pro Phe Gln  Glu Met Tyr Arg Pro  Ser Gly Met 
    1250                 1255                 1260             


Gln Met  His Pro Val Gln Ser  Gln Ala Ser Phe Pro  Lys Xaa Pro 
    1265                 1270                 1275             


Xaa Ala  Ala Xaa Ser Gln Glu  Glu Val Pro Pro His  Lys Pro Pro 
    1280                 1285                 1290             


Xaa Leu  Pro Leu Asp Gln Ser  
    1295                 1300 


<210> 5840
<211> 1301
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1187)..(1187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1247)..(1247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1278)..(1278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1280)..(1280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<400> 5840
Met Tyr Lys Glu Asp Pro Val Gln Gly Lys Ser Asn Gly Glu Leu Ser 
1               5                   10                  15      


Leu Ser Arg Glu Ser Glu Gly Gln Lys Asn Val Ser Ser Ile Pro Gly 
            20                  25                  30          


Lys Xaa Gly Lys Arg Arg Gly Arg Pro Pro Lys Arg Lys Lys Leu Gln 
        35                  40                  45              


Glu Glu Ile Leu Leu Ser Glu Lys Gln Glu Glu Asn Ser Leu Ala Ser 
    50                  55                  60                  


Glu Pro Gln Xaa Arg His Gly Ser Gln Gly Pro Gly Gln Gly Xaa Trp 
65                  70                  75                  80  


Trp Leu Leu Cys Gln Xaa Glu Glu Glu Trp Arg Gln Val Xaa Glu Ser 
                85                  90                  95      


Phe Arg Glu Arg Xaa Ser Leu Arg Glu Arg Gln Leu Tyr Lys Leu Leu 
            100                 105                 110         


Ser Glu Asp Phe Leu Pro Glu Ile Cys Asn Met Ile Ala Gln Lys Gly 
        115                 120                 125             


Lys Arg Pro Gln Arg Xaa Lys Ala Glu Leu His Pro Arg Trp Met Ser 
    130                 135                 140                 


Asp His Leu Ser Ile Lys Pro Val Lys Gln Glu Glu Xaa Pro Val Leu 
145                 150                 155                 160 


Xaa Arg Ile Glu Lys Gln Lys Arg Lys Glu Glu Glu Glu Glu Arg Gln 
                165                 170                 175     


Ile Leu Leu Ala Val Gln Lys Lys Glu Gln Glu Gln Met Leu Lys Glu 
            180                 185                 190         


Glu Arg Lys Arg Glu Leu Glu Glu Lys Val Lys Ala Val Glu Asp Arg 
        195                 200                 205             


Ala Lys Arg Arg Lys Leu Arg Glu Glu Arg Ala Trp Leu Leu Ala Gln 
    210                 215                 220                 


Gly Lys Glu Leu Pro Pro Glu Leu Ser His Leu Asp Pro Asn Ser Pro 
225                 230                 235                 240 


Met Arg Glu Glu Lys Lys Xaa Lys Asp Leu Phe Glu Leu Asp Asp Asp 
                245                 250                 255     


Phe Xaa Ala Met Tyr Lys Val Leu Asp Val Val Lys Ala His Lys Asp 
            260                 265                 270         


Ser Trp Pro Phe Leu Glu Pro Val Asp Glu Ser Tyr Ala Pro Asn Tyr 
        275                 280                 285             


Tyr Gln Ile Ile Lys Ala Pro Met Asp Ile Ser Ser Met Glu Lys Lys 
    290                 295                 300                 


Leu Asn Gly Gly Leu Tyr Cys Xaa Lys Glu Glu Phe Val Asn Asp Met 
305                 310                 315                 320 


Lys Xaa Met Phe Arg Asn Cys Arg Lys Tyr Asn Gly Glu Ser Ser Glu 
                325                 330                 335     


Tyr Xaa Lys Met Ser Asp Asn Leu Glu Arg Cys Phe His Arg Ala Met 
            340                 345                 350         


Met Lys His Phe Pro Gly Glu Asp Gly Asp Xaa Asp Glu Glu Phe Trp 
        355                 360                 365             


Ile Arg Glu Asp Glu Lys Arg Glu Lys Arg Arg Ser Arg Ala Gly Arg 
    370                 375                 380                 


Ser Gly Gly Ser His Val Trp Xaa Arg Ser Arg Asp Pro Glu Gly Ser 
385                 390                 395                 400 


Ser Arg Lys Gln Gln Pro Met Glu Asn Gly Gly Lys Ser Leu Pro Pro 
                405                 410                 415     


Xaa Arg Arg Ala Pro Ser Ser Gly Asp Asp Gln Ser Ser Ser Ser Xaa 
            420                 425                 430         


Gln Pro Pro Arg Glu Val Gly Xaa Ser Asn Gly Arg Gly Phe Ser His 
        435                 440                 445             


Pro Leu His Cys Gly Gly Xaa Pro Ser Gln Ala Pro Phe Leu Asn Gln 
    450                 455                 460                 


Met Arg Pro Ala Val Pro Gly Xaa Phe Gly Pro Leu Arg Gly Ser Asp 
465                 470                 475                 480 


Pro Ala Xaa Leu Tyr Gly Ser Ser Gly Val Pro Glu Pro His Pro Gly 
                485                 490                 495     


Glu Pro Val Gln Gln Arg Gln Pro Phe Xaa Met Gln Pro Pro Val Gly 
            500                 505                 510         


Ile Asn Ser Leu Arg Gly Pro Arg Leu Gly Xaa Pro Glu Glu Lys Gln 
        515                 520                 525             


Met Cys Gly Gly Leu Xaa His Leu Ser Asn Met Gly Pro His Pro Gly 
    530                 535                 540                 


Ser Leu Gln Leu Gly Gln Ile Ser Gly Pro Ser Gln Asp Gly Ser Met 
545                 550                 555                 560 


Tyr Ala Pro Ala Gln Phe Gln Pro Gly Phe Ile Pro Pro Arg His Gly 
                565                 570                 575     


Gly Ala Pro Ala Arg Pro Pro Asp Phe Pro Glu Ser Ser Glu Ile Pro 
            580                 585                 590         


Pro Ser His Met Tyr Arg Ser Tyr Lys Tyr Leu Asn Arg Val His Ser 
        595                 600                 605             


Ala Val Trp Asn Gly Asn His Gly Ala Xaa Asn Gln Gly Pro Leu Gly 
    610                 615                 620                 


Pro Asp Glu Lys Pro His Leu Gly Pro Gly Pro Ser His Gln Pro Arg 
625                 630                 635                 640 


Xaa Leu Gly His Val Met Asp Ser Arg Val Met Arg Pro Pro Val Pro 
                645                 650                 655     


Pro Asn Gln Trp Xaa Glu Gln Ser Gly Phe Leu Pro His Gly Val Pro 
            660                 665                 670         


Ser Ser Gly Tyr Met Arg Pro Pro Cys Lys Ser Ala Gly His Arg Leu 
        675                 680                 685             


Gln Pro Pro Pro Val Pro Ala Pro Ser Ser Leu Phe Gly Ala Pro Ala 
    690                 695                 700                 


Gln Ala Leu Arg Gly Val Gln Gly Gly Asp Ser Met Met Asp Ser Pro 
705                 710                 715                 720 


Glu Met Ile Ala Met Gln Gln Leu Ser Ser Arg Val Cys Pro Pro Gly 
                725                 730                 735     


Val Pro Tyr His Pro His Gln Pro Ala His Pro Arg Leu Pro Gly Pro 
            740                 745                 750         


Phe Pro Gln Val Ala His Pro Met Ser Val Xaa Val Ser Ala Pro Lys 
        755                 760                 765             


Pro Ala Leu Gly Asn Pro Gly Arg Ala Pro Glu Asn Ser Glu Ala Gln 
    770                 775                 780                 


Glu Pro Glu Asn Asp Gln Ala Glu Pro Leu Pro Gly Leu Glu Glu Lys 
785                 790                 795                 800 


Pro Pro Gly Val Gly Xaa Ser Glu Gly Val Tyr Leu Xaa Gln Leu Pro 
                805                 810                 815     


His Pro Xaa Pro Pro Leu Gln Xaa Asp Cys Xaa Arg Gln Ser Ser Pro 
            820                 825                 830         


Gln Glu Arg Glu Xaa Val Gly Pro Glu Leu Lys Ser Ser Ser Ser Glu 
        835                 840                 845             


Ser Ala Asp Asn Cys Lys Ala Met Lys Gly Lys Asn Pro Trp Pro Ser 
    850                 855                 860                 


Asp Ser Ser Tyr Pro Gly Pro Ala Ala Gln Gly Cys Val Arg Asp Leu 
865                 870                 875                 880 


Ser Xaa Val Ala Asp Arg Gly Ala Leu Ser Glu Asn Gly Val Ile Gly 
                885                 890                 895     


Glu Ala Ser Pro Cys Gly Ser Glu Gly Lys Gly Leu Gly Ser Ser Gly 
            900                 905                 910         


Ser Glu Lys Leu Leu Cys Pro Arg Gly Arg Xaa Leu Gln Glu Xaa Met 
        915                 920                 925             


Pro Cys Xaa Gly Gln Asn Ala Ala Xaa Pro Pro Ser Xaa Asp Pro Gly 
    930                 935                 940                 


Leu Xaa Gly Gly Xaa Val Ser Gln Phe Pro Pro Leu Tyr Met Pro Gly 
945                 950                 955                 960 


Leu Glu Tyr Pro Asn Ser Ala Ala His Tyr His Ile Ser Pro Gly Leu 
                965                 970                 975     


Gln Gly Val Gly Pro Val Met Gly Gly Lys Ser Pro Ala Ser His Pro 
            980                 985                 990         


Gln His Phe Pro Pro Arg Gly Phe  Gln Ser Asn His Pro  His Ser Gly 
        995                 1000                 1005             


Gly Phe  Pro Arg Tyr Arg Pro  Pro Gln Gly Met Arg  Tyr Ser Tyr 
    1010                 1015                 1020             


His Pro  Pro Pro Gln Pro Ser  Tyr His His Tyr Gln  Arg Xaa Pro 
    1025                 1030                 1035             


Tyr Tyr  Ala Cys Pro Gln Ser  Phe Ser Asp Trp Gln  Arg Pro Leu 
    1040                 1045                 1050             


His Pro  Gln Gly Ser Pro Ser  Gly Pro Pro Ala Ser  Gln Pro Pro 
    1055                 1060                 1065             


Pro Pro  Arg Ser Leu Phe Ser  Asp Lys Asn Ala Met  Ala Ser Leu 
    1070                 1075                 1080             


Gln Gly  Cys Glu Xaa Leu Asn  Ala Ala Leu Xaa Ser  Pro Xaa Arg 
    1085                 1090                 1095             


Met Asp  Ala Val Ala Ala Lys  Val Pro Asn Asp Gly  Gln Asn Pro 
    1100                 1105                 1110             


Gly Pro  Glu Glu Glu Lys Leu  Asp Glu Ser Met Glu  Arg Pro Glu 
    1115                 1120                 1125             


Ser Pro  Lys Glu Phe Leu Asp  Leu Asp Asn His Asn  Ala Ala Xaa 
    1130                 1135                 1140             


Lys Arg  Gln Ser Ser Leu Ser  Ala Ser Glu Tyr Leu  Tyr Gly Xaa 
    1145                 1150                 1155             


Pro Pro  Pro Leu Ser Ser Gly  Met Gly Phe Gly Ser  Ser Ala Phe 
    1160                 1165                 1170             


Pro Pro  His Ser Val Met Leu  Gln Xaa Gly Pro Pro  Tyr Xaa Pro 
    1175                 1180                 1185             


Gln Arg  Pro Ala Ser His Phe  Gln Pro Arg Ala Tyr  Ser Ser Pro 
    1190                 1195                 1200             


Val Ala  Ala Leu Pro Pro His  His Pro Gly Ala Xaa  Gln Pro Asn 
    1205                 1210                 1215             


Gly Leu  Ser Gln Glu Gly Pro  Ile Tyr Arg Cys Gln  Glu Glu Gly 
    1220                 1225                 1230             


Leu Gly  His Phe Gln Ala Val  Met Met Glu Gln Ile  Gly Xaa Arg 
    1235                 1240                 1245             


Ser Gly  Ile Arg Gly Pro Phe  Gln Glu Met Tyr Arg  Pro Ser Gly 
    1250                 1255                 1260             


Met Gln  Met His Pro Val Gln  Ser Gln Ala Ser Phe  Pro Lys Xaa 
    1265                 1270                 1275             


Pro Xaa  Ala Ala Xaa Ser Gln  Glu Glu Val Pro Pro  His Lys Pro 
    1280                 1285                 1290             


Pro Xaa  Leu Pro Leu Asp Gln  Ser 
    1295                 1300     


<210> 5841
<211> 218
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 5841
Ser Asp Lys Asn Ala Met Ala Ser Leu Gln Gly Cys Glu Xaa Leu Asn 
1               5                   10                  15      


Ala Ala Leu Xaa Ser Pro Xaa Arg Met Asp Ala Val Ala Ala Lys Val 
            20                  25                  30          


Pro Asn Asp Gly Gln Asn Pro Gly Pro Glu Glu Glu Lys Leu Asp Glu 
        35                  40                  45              


Ser Met Glu Arg Pro Glu Ser Pro Lys Glu Phe Leu Asp Leu Asp Asn 
    50                  55                  60                  


His Asn Ala Ala Xaa Lys Arg Gln Ser Ser Leu Ser Ala Ser Glu Tyr 
65                  70                  75                  80  


Leu Tyr Gly Xaa Pro Pro Pro Leu Ser Ser Gly Met Gly Phe Gly Ser 
                85                  90                  95      


Ser Ala Phe Pro Pro His Ser Val Met Leu Gln Xaa Gly Pro Pro Tyr 
            100                 105                 110         


Xaa Pro Gln Arg Pro Ala Ser His Phe Gln Pro Arg Ala Tyr Ser Ser 
        115                 120                 125             


Pro Val Ala Ala Leu Pro Pro His His Pro Gly Ala Xaa Gln Pro Asn 
    130                 135                 140                 


Gly Leu Ser Gln Glu Gly Pro Ile Tyr Arg Cys Gln Glu Glu Gly Leu 
145                 150                 155                 160 


Gly His Phe Gln Ala Val Met Met Glu Gln Ile Gly Xaa Arg Ser Gly 
                165                 170                 175     


Ile Arg Gly Pro Phe Gln Glu Met Tyr Arg Pro Ser Gly Phe Lys Arg 
            180                 185                 190         


Phe Ser Cys Leu Ile Leu Pro Ser Ser Trp Asp Tyr Arg Cys Pro Pro 
        195                 200                 205             


Pro His Leu Ala Glu Phe Cys Met Ile Leu 
    210                 215             


<210> 5842
<211> 258
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<400> 5842
Met Leu Val Leu Tyr Gly His Ser Xaa Gln Asp Leu Pro Glu Xaa Asn 
1               5                   10                  15      


Ala Arg Val Val Gly Gly Xaa Glu Ala Gly Arg Asn Ser Trp Pro Ser 
            20                  25                  30          


Gln Ile Ser Leu Gln Tyr Arg Ser Gly Gly Ser Arg Tyr His Xaa Cys 
        35                  40                  45              


Gly Gly Xaa Leu Ile Arg Gln Asn Trp Val Met Xaa Ala Ala His Cys 
    50                  55                  60                  


Val Asp Tyr Gln Lys Xaa Phe Arg Val Val Ala Gly Asp His Asn Leu 
65                  70                  75                  80  


Ser Gln Asn Asp Gly Xaa Glu Gln Tyr Val Ser Val Gln Lys Ile Val 
                85                  90                  95      


Val His Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile 
            100                 105                 110         


Ala Leu Leu Arg Leu Ala Gln Ser Val Xaa Leu Asn Ser Tyr Val Gln 
        115                 120                 125             


Leu Gly Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro 
    130                 135                 140                 


Cys Tyr Ile Xaa Gly Trp Gly Lys Xaa Lys Xaa Asn Gly Gln Leu Ala 
145                 150                 155                 160 


Gln Xaa Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys 
                165                 170                 175     


Ser Ser Ser Ser Tyr Trp Gly Ser Xaa Val Lys Asn Xaa Met Val Cys 
            180                 185                 190         


Ala Gly Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly 
        195                 200                 205             


Pro Leu His Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Xaa 
    210                 215                 220                 


Ser Phe Val Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Xaa Val 
225                 230                 235                 240 


Phe Xaa Gln Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala 
                245                 250                 255     


Ser Asn 
        


<210> 5843
<211> 3014
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1208)..(1208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1237)..(1238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1296)..(1296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1356)..(1356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1386)..(1386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1394)..(1394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1417)..(1417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1443)..(1444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1454)..(1454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1465)..(1465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1469)..(1469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1504)..(1504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1510)..(1513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1558)..(1558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1564)..(1565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1584)..(1584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1595)..(1595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1642)..(1642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1663)..(1663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1732)..(1732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1737)..(1737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1770)..(1770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1795)..(1795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1797)..(1797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1817)..(1817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1849)..(1849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1851)..(1851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1855)..(1855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1877)..(1877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1981)..(1981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1999)..(1999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2014)..(2014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2019)..(2019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2044)..(2045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2068)..(2068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2105)..(2106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2124)..(2124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2142)..(2142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2145)..(2145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2147)..(2147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2155)..(2155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2178)..(2178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2199)..(2199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2213)..(2213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2234)..(2234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2243)..(2243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2259)..(2259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2268)..(2268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2306)..(2307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2310)..(2311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2317)..(2317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2346)..(2346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2372)..(2372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2377)..(2377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2407)..(2407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2423)..(2423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2439)..(2439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2448)..(2448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2472)..(2472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2525)..(2525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2532)..(2532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2545)..(2545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2549)..(2549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2561)..(2561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2568)..(2568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2586)..(2586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2610)..(2610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2627)..(2627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2629)..(2629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2656)..(2656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2667)..(2667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2728)..(2729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2732)..(2732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2735)..(2735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2742)..(2743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2753)..(2753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2759)..(2759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2849)..(2849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2886)..(2886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2934)..(2934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2940)..(2940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2942)..(2942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2945)..(2945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2962)..(2962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2966)..(2966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2979)..(2979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3001)..(3001)
<223> Selenocysteine

<400> 5843
Met Ala Pro Pro Pro Pro Pro Val Leu Pro Val Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Ala Ala Ala Leu Pro Ala Met Gly Leu Arg Ala Ala Ala Trp Glu 
            20                  25                  30          


Pro Arg Val Pro Gly Gly Xaa Arg Ala Phe Ala Leu Arg Pro Gly Cys 
        35                  40                  45              


Xaa Tyr Ala Val Gly Ala Ala Cys Xaa Pro Arg Ala Pro Arg Glu Leu 
    50                  55                  60                  


Leu Asp Val Gly Arg Asp Gly Arg Leu Ala Gly Arg Arg Arg Val Ser 
65                  70                  75                  80  


Gly Ala Gly Arg Pro Leu Pro Leu Gln Val Arg Leu Val Ala Arg Ser 
                85                  90                  95      


Ala Pro Xaa Ala Leu Ser Arg Arg Leu Arg Ala Arg Xaa His Leu Pro 
            100                 105                 110         


Gly Cys Gly Ala Arg Ala Arg Leu Cys Gly Xaa Gly Ala Arg Leu Cys 
        115                 120                 125             


Gly Ala Leu Cys Phe Pro Val Pro Gly Gly Cys Ala Ala Ala Gln His 
    130                 135                 140                 


Ser Ala Leu Ala Ala Pro Xaa Xaa Leu Pro Ala Cys Arg Cys Pro Pro 
145                 150                 155                 160 


Arg Pro Arg Pro Arg Cys Pro Gly Arg Pro Ile Cys Leu Pro Pro Gly 
                165                 170                 175     


Gly Ser Val Arg Leu Arg Leu Leu Cys Ala Leu Arg Arg Ala Ala Gly 
            180                 185                 190         


Ala Val Arg Val Gly Leu Ala Leu Glu Ala Ala Xaa Ala Gly Xaa Pro 
        195                 200                 205             


Ser Ala Ser Pro Ser Pro Ser Pro Pro Leu Pro Pro Asn Leu Pro Glu 
    210                 215                 220                 


Ala Arg Ala Gly Pro Ala Arg Arg Ala Arg Arg Gly Xaa Ser Gly Arg 
225                 230                 235                 240 


Gly Ser Leu Lys Phe Pro Met Pro Asn Tyr Gln Val Ala Leu Phe Glu 
                245                 250                 255     


Asn Glu Pro Ala Gly Xaa Leu Ile Leu Gln Leu His Ala His Tyr Xaa 
            260                 265                 270         


Ile Glu Gly Glu Glu Glu Arg Val Ser Tyr Tyr Met Glu Gly Leu Phe 
        275                 280                 285             


Asp Glu Arg Ser Arg Gly Tyr Phe Arg Ile Asp Ser Ala Xaa Gly Ala 
    290                 295                 300                 


Val Ser Xaa Asp Ser Val Leu Asp Arg Glu Xaa Lys Glu Xaa His Val 
305                 310                 315                 320 


Leu Arg Val Lys Ala Val Asp Tyr Ser Xaa Pro Pro Arg Ser Ala Xaa 
                325                 330                 335     


Xaa Tyr Ile Xaa Val Leu Val Lys Asp Xaa Asn Asp His Ser Pro Val 
            340                 345                 350         


Phe Glu Gln Ser Glu Tyr Arg Glu Arg Val Arg Glu Asn Leu Glu Val 
        355                 360                 365             


Gly Tyr Glu Val Leu Xaa Ile Arg Ala Ser Asp Arg Asp Ser Pro Ile 
    370                 375                 380                 


Asn Ala Asn Leu Arg Tyr Arg Val Leu Gly Gly Ala Trp Asp Val Phe 
385                 390                 395                 400 


Gln Leu Asn Glu Ser Ser Gly Val Val Ser Xaa Arg Ala Val Leu Asp 
                405                 410                 415     


Arg Glu Glu Ala Ala Glu Tyr Gln Leu Leu Val Glu Ala Asn Asp Gln 
            420                 425                 430         


Gly Arg Asn Pro Gly Pro Leu Ser Ala Xaa Ala Xaa Val Tyr Ile Glu 
        435                 440                 445             


Val Glu Asp Glu Asn Asp Asn Tyr Pro Gln Phe Ser Glu Gln Asn Tyr 
    450                 455                 460                 


Val Val Gln Val Pro Glu Asp Val Gly Leu Asn Xaa Ala Val Leu Arg 
465                 470                 475                 480 


Val Gln Ala Xaa Asp Arg Asp Gln Gly Gln Asn Ala Ala Ile His Tyr 
                485                 490                 495     


Ser Ile Leu Ser Gly Asn Val Ala Gly Gln Phe Tyr Leu His Ser Leu 
            500                 505                 510         


Ser Gly Ile Leu Asp Val Ile Asn Pro Leu Asp Phe Glu Asp Val Gln 
        515                 520                 525             


Lys Tyr Ser Leu Ser Ile Lys Ala Gln Asp Gly Gly Arg Pro Pro Leu 
    530                 535                 540                 


Ile Asn Ser Ser Gly Val Val Ser Val Gln Val Leu Asp Val Asn Asp 
545                 550                 555                 560 


Asn Glu Pro Ile Phe Val Ser Ser Pro Phe Gln Ala Xaa Val Leu Glu 
                565                 570                 575     


Asn Val Pro Leu Gly Tyr Pro Val Val His Ile Gln Ala Val Asp Ala 
            580                 585                 590         


Asp Ser Gly Glu Asn Ala Arg Leu His Tyr Arg Leu Val Asp Xaa Ala 
        595                 600                 605             


Ser Xaa Phe Leu Gly Gly Gly Ser Ala Gly Pro Lys Asn Pro Ala Pro 
    610                 615                 620                 


Xaa Pro Asp Phe Pro Phe Gln Ile His Asn Ser Ser Gly Trp Ile Xaa 
625                 630                 635                 640 


Val Cys Ala Glu Leu Asp Arg Glu Glu Val Glu His Tyr Ser Phe Gly 
                645                 650                 655     


Val Glu Ala Val Asp His Gly Ser Pro Pro Met Ser Ser Ser Xaa Ser 
            660                 665                 670         


Val Ser Ile Xaa Val Leu Asp Val Asn Asp Asn Asp Pro Val Phe Xaa 
        675                 680                 685             


Gln Pro Xaa Tyr Glu Leu Arg Leu Asn Glu Asp Ala Ala Val Gly Ser 
    690                 695                 700                 


Ser Val Leu Xaa Leu Gln Ala Arg Asp Arg Asp Ala Asn Ser Val Ile 
705                 710                 715                 720 


Xaa Tyr Gln Leu Xaa Gly Gly Asn Xaa Arg Asn Arg Phe Ala Leu Ser 
                725                 730                 735     


Ser Gln Arg Gly Gly Gly Leu Ile Xaa Leu Ala Leu Pro Leu Asp Tyr 
            740                 745                 750         


Lys Gln Glu Gln Gln Tyr Val Leu Ala Val Xaa Ala Ser Asp Gly Xaa 
        755                 760                 765             


Arg Ser His Xaa Ala His Val Leu Ile Asn Val Xaa Asp Ala Asn Xaa 
    770                 775                 780                 


His Arg Pro Val Phe Gln Ser Ser His Tyr Xaa Val Ser Val Ser Glu 
785                 790                 795                 800 


Asp Arg Pro Val Gly Xaa Ser Ile Ala Xaa Leu Ser Ala Asn Asp Glu 
                805                 810                 815     


Asp Xaa Gly Glu Asn Ala Arg Ile Xaa Tyr Val Ile Gln Asp Pro Val 
            820                 825                 830         


Pro Gln Phe Arg Ile Asp Pro Asp Ser Gly Xaa Met Tyr Xaa Met Met 
        835                 840                 845             


Glu Leu Asp Tyr Glu Asn Gln Val Ala Tyr Xaa Leu Xaa Ile Met Ala 
    850                 855                 860                 


Gln Asp Asn Gly Ile Pro Gln Lys Ser Asp Xaa Xaa Xaa Leu Glu Ile 
865                 870                 875                 880 


Leu Ile Leu Asp Ala Asn Asp Asn Ala Pro Gln Phe Leu Trp Asp Phe 
                885                 890                 895     


Tyr Gln Gly Ser Ile Phe Glu Asp Ala Pro Pro Ser Xaa Ser Ile Leu 
            900                 905                 910         


Gln Val Ser Ala Xaa Asp Arg Asp Ser Gly Pro Asn Gly Arg Leu Leu 
        915                 920                 925             


Tyr Xaa Phe Gln Gly Gly Asp Asp Gly Asp Gly Asp Phe Tyr Ile Glu 
    930                 935                 940                 


Pro Xaa Ser Gly Val Ile Arg Xaa Gln Arg Arg Leu Asp Arg Glu Asn 
945                 950                 955                 960 


Val Ala Val Tyr Asn Leu Trp Ala Leu Ala Val Asp Arg Gly Ser Pro 
                965                 970                 975     


Xaa Pro Leu Ser Ala Ser Val Glu Ile Gln Val Xaa Ile Leu Asp Ile 
            980                 985                 990         


Asn Asp Asn Ala Pro Met Phe Glu  Lys Asp Glu Leu Glu  Leu Phe Val 
        995                 1000                 1005             


Glu Glu  Asn Asn Pro Val Gly  Ser Val Val Ala Lys  Ile Arg Ala 
    1010                 1015                 1020             


Asn Asp  Pro Asp Glu Gly Pro  Asn Ala Gln Ile Met  Tyr Gln Ile 
    1025                 1030                 1035             


Val Glu  Gly Asp Met Arg His  Phe Phe Gln Leu Asp  Leu Leu Asn 
    1040                 1045                 1050             


Gly Asp  Leu Arg Ala Met Val  Glu Leu Asp Phe Glu  Val Arg Arg 
    1055                 1060                 1065             


Glu Tyr  Val Leu Val Val Gln  Ala Xaa Ser Ala Pro  Leu Val Ser 
    1070                 1075                 1080             


Arg Ala  Xaa Val His Ile Leu  Leu Val Asp Gln Asn  Asp Asn Pro 
    1085                 1090                 1095             


Pro Val  Leu Pro Asp Phe Gln  Ile Leu Phe Asn Asn  Tyr Val Xaa 
    1100                 1105                 1110             


Asn Lys  Ser Asn Ser Phe Pro  Xaa Gly Val Ile Gly  Cys Ile Pro 
    1115                 1120                 1125             


Ala His  Asp Pro Asp Val Ser  Asp Ser Leu Asn Tyr  Xaa Phe Val 
    1130                 1135                 1140             


Gln Gly  Asn Glu Leu Arg Leu  Leu Leu Leu Asp Pro  Ala Xaa Gly 
    1145                 1150                 1155             


Glu Leu  Gln Leu Ser Arg Asp  Leu Asp Asn Asn Arg  Pro Leu Glu 
    1160                 1165                 1170             


Ala Leu  Met Glu Val Ser Val  Ser Asp Gly Ile His  Ser Val Xaa 
    1175                 1180                 1185             


Ala Phe  Cys Xaa Leu Arg Val  Xaa Ile Ile Xaa Asp  Asp Met Leu 
    1190                 1195                 1200             


Xaa Asn  Ser Ile Xaa Val Arg  Leu Glu Asn Met Ser  Gln Glu Lys 
    1205                 1210                 1215             


Phe Leu  Ser Pro Leu Leu Ala  Leu Phe Val Glu Gly  Val Ala Ala 
    1220                 1225                 1230             


Val Leu  Ser Xaa Xaa Lys Asp  Asp Val Phe Val Phe  Asn Val Gln 
    1235                 1240                 1245             


Asn Asp  Xaa Asp Val Ser Ser  Asn Ile Leu Asn Val  Xaa Phe Ser 
    1250                 1255                 1260             


Ala Leu  Leu Pro Gly Gly Val  Arg Gly Gln Phe Phe  Pro Ser Glu 
    1265                 1270                 1275             


Asp Leu  Gln Glu Gln Ile Tyr  Leu Asn Arg Xaa Leu  Leu Xaa Xaa 
    1280                 1285                 1290             


Ile Ser  Xaa Gln Arg Val Leu  Pro Phe Asp Asp Asn  Ile Cys Leu 
    1295                 1300                 1305             


Arg Glu  Pro Cys Glu Asn Tyr  Met Lys Cys Val Ser  Val Leu Arg 
    1310                 1315                 1320             


Phe Asp  Ser Ser Ala Pro Phe  Leu Ser Ser Xaa Xaa  Val Leu Phe 
    1325                 1330                 1335             


Arg Pro  Ile His Pro Ile Asn  Gly Leu Arg Cys Arg  Cys Pro Pro 
    1340                 1345                 1350             


Gly Phe  Xaa Gly Asp Tyr Cys  Glu Xaa Glu Ile Asp  Leu Cys Tyr 
    1355                 1360                 1365             


Ser Asp  Pro Cys Gly Ala Asn  Gly Arg Cys Arg Ser  Arg Glu Gly 
    1370                 1375                 1380             


Gly Tyr  Xaa Cys Glu Cys Phe  Glu Asp Phe Xaa Gly  Glu His Cys 
    1385                 1390                 1395             


Glu Val  Asp Ala Arg Ser Gly  Arg Cys Ala Asn Gly  Val Cys Lys 
    1400                 1405                 1410             


Asn Gly  Gly Xaa Cys Val Asn  Leu Leu Ile Gly Gly  Phe His Cys 
    1415                 1420                 1425             


Val Cys  Pro Pro Gly Glu Tyr  Glu Arg Pro Tyr Cys  Glu Val Xaa 
    1430                 1435                 1440             


Xaa Arg  Ser Phe Pro Pro Gln  Ser Phe Val Xaa Phe  Arg Gly Leu 
    1445                 1450                 1455             


Arg Gln  Arg Phe His Phe Xaa  Ile Ser Leu Xaa Phe  Ala Xaa Gln 
    1460                 1465                 1470             


Glu Arg  Asn Gly Leu Leu Leu  Tyr Asn Gly Arg Phe  Asn Glu Lys 
    1475                 1480                 1485             


His Asp  Phe Ile Ala Leu Glu  Ile Val Asp Glu Gln  Val Gln Leu 
    1490                 1495                 1500             


Xaa Phe  Ser Ala Gly Glu Xaa  Xaa Xaa Xaa Val Ala  Pro Lys Val 
    1505                 1510                 1515             


Pro Ser  Gly Val Ser Asp Gly  Arg Trp His Ser Val  Gln Val Gln 
    1520                 1525                 1530             


Tyr Tyr  Asn Lys Pro Asn Ile  Gly His Leu Gly Leu  Pro His Gly 
    1535                 1540                 1545             


Pro Ser  Gly Glu Lys Met Ala  Val Val Xaa Val Asp  Asp Cys Asp 
    1550                 1555                 1560             


Xaa Xaa  Met Ala Val Arg Phe  Gly Lys Asp Ile Gly  Asn Tyr Ser 
    1565                 1570                 1575             


Cys Ala  Ala Gln Gly Xaa Gln  Xaa Gly Ser Lys Lys  Ser Leu Asp 
    1580                 1585                 1590             


Leu Xaa  Gly Pro Leu Leu Leu  Gly Gly Val Pro Asn  Leu Pro Glu 
    1595                 1600                 1605             


Asp Phe  Pro Val His Asn Arg  Gln Phe Val Gly Cys  Met Arg Asn 
    1610                 1615                 1620             


Leu Ser  Val Asp Gly Lys Asn  Val Asp Met Ala Gly  Phe Ile Ala 
    1625                 1630                 1635             


Asn Asn  Gly Xaa Arg Glu Gly  Cys Ala Ala Arg Arg  Asn Phe Cys 
    1640                 1645                 1650             


Asp Gly  Arg Arg Cys Gln Asn  Gly Gly Xaa Cys Val  Asn Arg Trp 
    1655                 1660                 1665             


Asn Met  Tyr Leu Cys Glu Cys  Pro Leu Arg Phe Gly  Gly Lys Asn 
    1670                 1675                 1680             


Cys Glu  Gln Ala Met Pro His  Pro Gln Leu Phe Ser  Gly Glu Ser 
    1685                 1690                 1695             


Val Val  Ser Trp Ser Asp Leu  Asn Ile Ile Ile Ser  Val Pro Trp 
    1700                 1705                 1710             


Tyr Leu  Gly Leu Met Phe Arg  Xaa Arg Lys Glu Asp  Ser Val Leu 
    1715                 1720                 1725             


Met Glu  Ala Xaa Ser Gly Gly  Pro Xaa Ser Phe Arg  Leu Gln Ile 
    1730                 1735                 1740             


Leu Asn  Asn Tyr Leu Gln Phe  Glu Val Ser His Gly  Pro Ser Asp 
    1745                 1750                 1755             


Val Glu  Ser Val Met Leu Ser  Gly Leu Arg Val Xaa  Asp Gly Glu 
    1760                 1765                 1770             


Trp His  His Leu Leu Ile Glu  Leu Lys Asn Val Lys  Glu Asp Ser 
    1775                 1780                 1785             


Glu Met  Lys His Leu Val Xaa  Met Xaa Leu Asp Tyr  Gly Met Asp 
    1790                 1795                 1800             


Gln Asn  Lys Ala Asp Ile Gly  Gly Met Leu Pro Gly  Leu Xaa Val 
    1805                 1810                 1815             


Arg Ser  Val Val Val Gly Gly  Ala Ser Glu Asp Lys  Val Ser Val 
    1820                 1825                 1830             


Arg Arg  Gly Phe Arg Gly Cys  Met Gln Gly Val Arg  Met Gly Gly 
    1835                 1840                 1845             


Xaa Pro  Xaa Asn Val Ala Xaa  Leu Asn Met Asn Asn  Ala Leu Lys 
    1850                 1855                 1860             


Val Arg  Val Lys Asp Gly Cys  Asp Val Asp Asp Pro  Cys Xaa Ser 
    1865                 1870                 1875             


Ser Pro  Cys Pro Pro Asn Ser  Arg Cys His Asp Ala  Trp Glu Asp 
    1880                 1885                 1890             


Tyr Ser  Cys Val Cys Asp Lys  Gly Tyr Leu Gly Ile  Asn Cys Val 
    1895                 1900                 1905             


Asp Ala  Cys His Leu Asn Pro  Cys Glu Asn Met Gly  Ala Cys Val 
    1910                 1915                 1920             


Arg Ser  Pro Gly Ser Pro Gln  Gly Tyr Val Cys Glu  Cys Gly Pro 
    1925                 1930                 1935             


Ser His  Tyr Gly Pro Tyr Cys  Glu Asn Lys Leu Asp  Leu Pro Cys 
    1940                 1945                 1950             


Pro Arg  Gly Trp Trp Gly Asn  Pro Val Cys Gly Pro  Cys His Cys 
    1955                 1960                 1965             


Ala Val  Ser Lys Gly Phe Asp  Pro Asp Cys Asn Lys  Xaa Asn Gly 
    1970                 1975                 1980             


Gln Cys  Gln Cys Lys Glu Asn  Tyr Tyr Lys Leu Leu  Ala Gln Asp 
    1985                 1990                 1995             


Xaa Cys  Leu Pro Cys Asp Cys  Phe Pro His Gly Ser  His Ser Arg 
    2000                 2005                 2010             


Xaa Cys  Asp Met Ala Xaa Gly  Gln Cys Ala Cys Lys  Pro Gly Val 
    2015                 2020                 2025             


Ile Gly  Arg Gln Cys Asn Arg  Cys Asp Asn Pro Phe  Ala Glu Val 
    2030                 2035                 2040             


Xaa Xaa  Leu Gly Cys Glu Val  Ile Tyr Asn Gly Cys  Pro Lys Ala 
    2045                 2050                 2055             


Phe Glu  Ala Gly Ile Trp Trp  Pro Gln Xaa Lys Phe  Gly Gln Pro 
    2060                 2065                 2070             


Ala Ala  Val Pro Cys Pro Lys  Gly Ser Val Gly Asn  Ala Val Arg 
    2075                 2080                 2085             


His Cys  Ser Gly Glu Lys Gly  Trp Leu Pro Pro Glu  Leu Phe Asn 
    2090                 2095                 2100             


Cys Xaa  Xaa Ile Ser Phe Val  Asp Leu Arg Ala Met  Asn Glu Lys 
    2105                 2110                 2115             


Leu Ser  Arg Asn Glu Xaa Gln  Val Asp Gly Ala Arg  Ala Leu Gln 
    2120                 2125                 2130             


Leu Val  Arg Ala Leu Arg Ser  Ala Xaa Gln His Xaa  Gly Xaa Leu 
    2135                 2140                 2145             


Phe Gly  Asn Asp Val Arg Xaa  Ala Tyr Gln Leu Leu  Gly His Val 
    2150                 2155                 2160             


Leu Gln  His Glu Ser Trp Gln  Gln Gly Phe Asp Leu  Ala Ala Xaa 
    2165                 2170                 2175             


Gln Asp  Ala Asp Phe His Glu  Asp Val Ile His Ser  Gly Ser Ala 
    2180                 2185                 2190             


Leu Leu  Ala Pro Ala Xaa Arg  Ala Ala Trp Glu Gln  Ile Gln Arg 
    2195                 2200                 2205             


Ser Glu  Gly Gly Xaa Ala Gln  Leu Leu Arg Arg Leu  Glu Gly Tyr 
    2210                 2215                 2220             


Phe Ser  Asn Val Ala Arg Asn  Val Arg Arg Xaa Tyr  Leu Arg Pro 
    2225                 2230                 2235             


Phe Val  Ile Val Xaa Ala Asn  Met Ile Leu Ala Val  Asp Ile Phe 
    2240                 2245                 2250             


Asp Lys  Phe Asn Phe Xaa Gly  Ala Arg Val Pro Arg  Phe Asp Xaa 
    2255                 2260                 2265             


Ile His  Glu Glu Phe Pro Arg  Glu Leu Glu Ser Ser  Val Ser Phe 
    2270                 2275                 2280             


Pro Ala  Asp Phe Phe Arg Pro  Pro Glu Glu Lys Glu  Gly Pro Leu 
    2285                 2290                 2295             


Leu Arg  Pro Ala Gly Arg Arg  Xaa Xaa Pro Gln Xaa  Xaa Arg Pro 
    2300                 2305                 2310             


Gly Pro  Gly Xaa Glu Arg Glu  Ala Pro Ile Ser Arg  Arg Arg Arg 
    2315                 2320                 2325             


His Pro  Asp Asp Ala Gly Gln  Phe Ala Val Ala Leu  Val Ile Ile 
    2330                 2335                 2340             


Tyr Arg  Xaa Leu Gly Gln Leu  Leu Pro Glu Arg Tyr  Asp Pro Asp 
    2345                 2350                 2355             


Arg Arg  Ser Leu Arg Leu Pro  His Arg Pro Ile Ile  Asn Xaa Pro 
    2360                 2365                 2370             


Met Val  Ser Xaa Leu Val Tyr  Ser Glu Gly Ala Pro  Leu Pro Arg 
    2375                 2380                 2385             


Pro Leu  Glu Arg Pro Val Leu  Val Glu Phe Ala Leu  Leu Glu Val 
    2390                 2395                 2400             


Glu Glu  Arg Xaa Lys Pro Val  Cys Val Phe Trp Asn  His Ser Leu 
    2405                 2410                 2415             


Ala Val  Gly Gly Xaa Gly Gly  Trp Ser Ala Arg Gly  Cys Glu Leu 
    2420                 2425                 2430             


Leu Ser  Arg Asn Arg Xaa His  Val Ala Cys Gln Cys  Ser His Xaa 
    2435                 2440                 2445             


Ala Ser  Phe Ala Val Leu Met  Asp Ile Ser Arg Arg  Glu Asn Gly 
    2450                 2455                 2460             


Glu Val  Leu Pro Leu Lys Ile  Val Xaa Tyr Ala Ala  Val Ser Leu 
    2465                 2470                 2475             


Ser Leu  Ala Ala Leu Leu Val  Ala Phe Val Leu Leu  Ser Leu Val 
    2480                 2485                 2490             


Arg Met  Leu Arg Ser Asn Leu  His Ser Ile His Lys  His Leu Ala 
    2495                 2500                 2505             


Val Ala  Leu Phe Leu Ser Gln  Leu Val Phe Val Ile  Gly Ile Asn 
    2510                 2515                 2520             


Gln Xaa  Glu Asn Pro Phe Leu  Cys Xaa Val Val Ala  Ile Leu Leu 
    2525                 2530                 2535             


His Tyr  Ile Tyr Met Ser Xaa  Phe Ala Trp Xaa Leu  Val Glu Ser 
    2540                 2545                 2550             


Leu His  Val Tyr Arg Met Leu  Xaa Glu Val Arg Asn  Ile Asp Xaa 
    2555                 2560                 2565             


Gly Pro  Met Arg Phe Tyr Tyr  Val Val Gly Trp Gly  Ile Pro Ala 
    2570                 2575                 2580             


Ile Val  Xaa Gly Leu Ala Val  Gly Leu Asp Pro Gln  Gly Tyr Gly 
    2585                 2590                 2595             


Asn Pro  Asp Phe Cys Trp Leu  Ser Leu Gln Asp Xaa  Leu Ile Trp 
    2600                 2605                 2610             


Ser Phe  Ala Gly Pro Ile Gly  Ala Val Ile Ile Ile  Asn Xaa Val 
    2615                 2620                 2625             


Xaa Ser  Val Leu Ser Ala Lys  Val Ser Cys Gln Arg  Lys His His 
    2630                 2635                 2640             


Tyr Tyr  Gly Lys Lys Gly Ile  Val Ser Leu Leu Arg  Xaa Ala Phe 
    2645                 2650                 2655             


Leu Leu  Leu Leu Leu Ile Ser  Ala Xaa Trp Leu Leu  Gly Leu Leu 
    2660                 2665                 2670             


Ala Val  Asn Arg Asp Ala Leu  Ser Phe His Tyr Leu  Phe Ala Ile 
    2675                 2680                 2685             


Phe Ser  Gly Leu Gln Gly Pro  Phe Val Leu Leu Phe  His Cys Val 
    2690                 2695                 2700             


Leu Asn  Gln Glu Val Arg Lys  His Leu Lys Gly Val  Leu Gly Gly 
    2705                 2710                 2715             


Arg Lys  Leu His Leu Glu Asp  Ser Ala Xaa Xaa Arg  Ala Xaa Leu 
    2720                 2725                 2730             


Leu Xaa  Arg Ser Leu Asn Cys  Asn Xaa Xaa Phe Gly  Asp Gly Pro 
    2735                 2740                 2745             


Asp Met  Leu Arg Xaa Asp Leu  Gly Glu Ser Xaa Ala  Ser Leu Asp 
    2750                 2755                 2760             


Ser Ile  Val Arg Asp Glu Gly  Ile Gln Lys Leu Gly  Val Ser Ser 
    2765                 2770                 2775             


Gly Leu  Val Arg Gly Ser His  Gly Glu Pro Asp Ala  Ser Leu Met 
    2780                 2785                 2790             


Pro Arg  Ser Cys Lys Asp Pro  Pro Gly His Asp Ser  Asp Ser Asp 
    2795                 2800                 2805             


Ser Glu  Leu Ser Leu Asp Glu  Gln Ser Ser Ser Tyr  Ala Ser Ser 
    2810                 2815                 2820             


His Ser  Ser Asp Ser Glu Asp  Asp Gly Val Gly Ala  Glu Glu Lys 
    2825                 2830                 2835             


Trp Asp  Pro Ala Arg Gly Ala  Val His Ser Xaa Pro  Lys Gly Asp 
    2840                 2845                 2850             


Ala Val  Ala Asn His Val Pro  Ala Gly Trp Pro Asp  Gln Ser Leu 
    2855                 2860                 2865             


Ala Glu  Ser Asp Ser Glu Asp  Pro Ser Gly Lys Pro  Arg Leu Lys 
    2870                 2875                 2880             


Val Glu  Xaa Lys Val Ser Val  Glu Leu His Arg Glu  Glu Gln Gly 
    2885                 2890                 2895             


Ser His  Arg Gly Glu Tyr Pro  Pro Asp Gln Glu Ser  Gly Gly Ala 
    2900                 2905                 2910             


Ala Arg  Leu Ala Ser Ser Gln  Pro Pro Glu Gln Arg  Lys Gly Ile 
    2915                 2920                 2925             


Leu Lys  Asn Lys Val Xaa Tyr  Pro Pro Pro Leu Xaa  Leu Xaa Glu 
    2930                 2935                 2940             


Gln Xaa  Leu Lys Gly Arg Leu  Arg Glu Lys Leu Ala  Asp Cys Glu 
    2945                 2950                 2955             


Gln Ser  Pro Xaa Ser Ser Arg  Xaa Ser Ser Leu Gly  Ser Gly Gly 
    2960                 2965                 2970             


Pro Asp  Cys Ala Ile Xaa Val  Lys Ser Pro Gly Arg  Glu Pro Gly 
    2975                 2980                 2985             


Arg Asp  His Leu Asn Gly Val  Ala Met Asn Val Arg  Xaa Gly Ser 
    2990                 2995                 3000             


Ala Gln  Ala Asp Gly Ser Asp  Ser Glu Lys Pro 
    3005                 3010                 


<210> 5844
<211> 772
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(710)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<400> 5844
Xaa Asp Phe Pro Phe Gln Ile His Asn Ser Ser Gly Trp Ile Xaa Val 
1               5                   10                  15      


Cys Ala Glu Leu Asp Arg Glu Glu Val Glu His Tyr Ser Phe Gly Val 
            20                  25                  30          


Glu Ala Val Asp His Gly Ser Pro Pro Met Ser Ser Ser Xaa Ser Val 
        35                  40                  45              


Ser Ile Xaa Val Leu Asp Val Asn Asp Asn Asp Pro Val Phe Xaa Gln 
    50                  55                  60                  


Pro Xaa Tyr Glu Leu Arg Leu Asn Glu Asp Ala Ala Val Gly Ser Ser 
65                  70                  75                  80  


Val Leu Xaa Leu Gln Ala Arg Asp Arg Asp Ala Asn Ser Val Ile Xaa 
                85                  90                  95      


Tyr Gln Leu Xaa Gly Gly Asn Xaa Arg Asn Arg Phe Ala Leu Ser Ser 
            100                 105                 110         


Gln Arg Gly Gly Gly Leu Ile Xaa Leu Ala Leu Pro Leu Asp Tyr Lys 
        115                 120                 125             


Gln Glu Gln Gln Tyr Val Leu Ala Val Xaa Ala Ser Asp Gly Xaa Arg 
    130                 135                 140                 


Ser His Xaa Ala His Val Leu Ile Asn Val Xaa Asp Ala Asn Xaa His 
145                 150                 155                 160 


Arg Pro Val Phe Gln Ser Ser His Tyr Xaa Val Ser Val Ser Glu Asp 
                165                 170                 175     


Arg Pro Val Gly Xaa Ser Ile Ala Xaa Leu Ser Ala Asn Asp Glu Asp 
            180                 185                 190         


Xaa Gly Glu Asn Ala Arg Ile Xaa Tyr Val Ile Gln Asp Pro Val Pro 
        195                 200                 205             


Gln Phe Arg Ile Asp Pro Asp Ser Gly Xaa Met Tyr Xaa Met Met Glu 
    210                 215                 220                 


Leu Asp Tyr Glu Asn Gln Val Ala Tyr Xaa Leu Xaa Ile Met Ala Gln 
225                 230                 235                 240 


Asp Asn Gly Ile Pro Gln Lys Ser Asp Xaa Xaa Xaa Leu Glu Ile Leu 
                245                 250                 255     


Ile Leu Asp Ala Asn Asp Asn Ala Pro Gln Phe Leu Trp Asp Phe Tyr 
            260                 265                 270         


Gln Gly Ser Ile Phe Glu Asp Ala Pro Pro Ser Xaa Ser Ile Leu Gln 
        275                 280                 285             


Val Ser Ala Xaa Asp Arg Asp Ser Gly Pro Asn Gly Arg Leu Leu Tyr 
    290                 295                 300                 


Xaa Phe Gln Gly Gly Asp Asp Gly Asp Gly Asp Phe Tyr Ile Glu Pro 
305                 310                 315                 320 


Xaa Ser Gly Val Ile Arg Xaa Gln Arg Arg Leu Asp Arg Glu Asn Val 
                325                 330                 335     


Ala Val Tyr Asn Leu Trp Ala Leu Ala Val Asp Arg Gly Ser Pro Xaa 
            340                 345                 350         


Pro Leu Ser Ala Ser Val Glu Ile Gln Val Xaa Ile Leu Asp Ile Asn 
        355                 360                 365             


Asp Asn Ala Pro Met Phe Glu Lys Asp Glu Leu Glu Leu Phe Val Glu 
    370                 375                 380                 


Glu Asn Asn Pro Val Gly Ser Val Val Ala Lys Ile Arg Ala Asn Asp 
385                 390                 395                 400 


Pro Asp Glu Gly Pro Asn Ala Gln Ile Met Tyr Gln Ile Val Glu Gly 
                405                 410                 415     


Asp Met Arg His Phe Phe Gln Leu Asp Leu Leu Asn Gly Asp Leu Arg 
            420                 425                 430         


Ala Met Val Glu Leu Asp Phe Glu Val Arg Arg Glu Tyr Val Leu Val 
        435                 440                 445             


Val Gln Ala Xaa Ser Ala Pro Leu Val Ser Arg Ala Xaa Val His Ile 
    450                 455                 460                 


Leu Leu Val Asp Gln Asn Asp Asn Pro Pro Val Leu Pro Asp Phe Gln 
465                 470                 475                 480 


Ile Leu Phe Asn Asn Tyr Val Xaa Asn Lys Ser Asn Ser Phe Pro Xaa 
                485                 490                 495     


Gly Val Ile Gly Cys Ile Pro Ala His Asp Pro Asp Val Ser Asp Ser 
            500                 505                 510         


Leu Asn Tyr Xaa Phe Val Gln Gly Asn Glu Leu Arg Leu Leu Leu Leu 
        515                 520                 525             


Asp Pro Ala Xaa Gly Glu Leu Gln Leu Ser Arg Asp Leu Asp Asn Asn 
    530                 535                 540                 


Arg Pro Leu Glu Ala Leu Met Glu Val Ser Val Ser Asp Gly Ile His 
545                 550                 555                 560 


Ser Val Xaa Ala Phe Cys Xaa Leu Arg Val Xaa Ile Ile Xaa Asp Asp 
                565                 570                 575     


Met Leu Xaa Asn Ser Ile Xaa Val Arg Leu Glu Asn Met Ser Gln Glu 
            580                 585                 590         


Lys Phe Leu Ser Pro Leu Leu Ala Leu Phe Val Glu Gly Val Ala Ala 
        595                 600                 605             


Val Leu Ser Xaa Xaa Lys Asp Asp Val Phe Val Phe Asn Val Gln Asn 
    610                 615                 620                 


Asp Xaa Asp Val Ser Ser Asn Ile Leu Asn Val Xaa Phe Ser Ala Leu 
625                 630                 635                 640 


Leu Pro Gly Gly Val Arg Gly Gln Phe Phe Pro Ser Glu Asp Leu Gln 
                645                 650                 655     


Glu Gln Ile Tyr Leu Asn Arg Xaa Leu Leu Xaa Xaa Ile Ser Xaa Gln 
            660                 665                 670         


Arg Val Leu Pro Phe Asp Asp Asn Ile Cys Leu Arg Glu Pro Cys Glu 
        675                 680                 685             


Asn Tyr Met Lys Cys Val Ser Val Leu Arg Phe Asp Ser Ser Ala Pro 
    690                 695                 700                 


Phe Leu Ser Ser Xaa Xaa Val Leu Phe Arg Pro Ile His Pro Ile Asn 
705                 710                 715                 720 


Gly Leu Arg Cys Arg Cys Pro Pro Gly Phe Xaa Gly Asp Tyr Cys Glu 
                725                 730                 735     


Xaa Glu Ile Asp Leu Cys Tyr Ser Asp Pro Cys Gly Ala Asn Gly Arg 
            740                 745                 750         


Cys Arg Ser Arg Glu Gly Gly Tyr Xaa Cys Glu Cys Phe Glu Asp Phe 
        755                 760                 765             


Xaa Glu Ile Ser 
    770         


<210> 5845
<211> 2923
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1173)..(1173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1281)..(1281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1287)..(1287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1319)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1342)..(1342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1368)..(1369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1379)..(1379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1397)..(1397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1429)..(1429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1436)..(1438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1454)..(1454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1483)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1489)..(1489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1509)..(1509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1520)..(1520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1567)..(1567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1588)..(1588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1658)..(1658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1663)..(1663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1665)..(1665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1680)..(1680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1743)..(1743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1770)..(1770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1829)..(1829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1844)..(1844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1854)..(1854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1868)..(1868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1883)..(1883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1902)..(1902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1920)..(1920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1929)..(1929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1965)..(1966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1989)..(1989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2006)..(2006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2026)..(2026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2029)..(2029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2063)..(2063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2066)..(2066)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2082)..(2082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2090)..(2090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2099)..(2099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2105)..(2105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2118)..(2118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2130)..(2130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2134)..(2134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2155)..(2155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2161)..(2161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2164)..(2164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2200)..(2201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2212)..(2212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2254)..(2254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2280)..(2280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2303)..(2303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2311)..(2311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2315)..(2315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2331)..(2331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2357)..(2357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2378)..(2378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2380)..(2380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2387)..(2387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2394)..(2394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2399)..(2399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2416)..(2416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2440)..(2440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2453)..(2453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2469)..(2469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2476)..(2476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2494)..(2494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2518)..(2518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2575)..(2575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2587)..(2587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2596)..(2596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2635)..(2636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2639)..(2639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2641)..(2641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2669)..(2669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2718)..(2718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2737)..(2737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2777)..(2777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2796)..(2797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2846)..(2846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2862)..(2862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2906)..(2906)
<223> Selenocysteine

<400> 5845
Met Arg Ser Pro Ala Xaa Gly Val Pro Leu Pro Xaa Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Leu Leu Gly Asp 
            20                  25                  30          


Gln Val Gly Pro Cys Arg Ser Leu Gly Ser Arg Gly Arg Gly Ser Ser 
        35                  40                  45              


Gly Ala Cys Ala Pro Met Gly Trp Leu Cys Pro Ser Ser Ala Ser Asn 
    50                  55                  60                  


Leu Trp Leu Tyr Xaa Ser Arg Cys Arg Asp Ala Gly Xaa Glu Leu Xaa 
65                  70                  75                  80  


Gly His Leu Val Pro His His Asp Gly Leu Arg Val Trp Cys Pro Glu 
                85                  90                  95      


Ser Glu Ala His Ile Pro Leu Pro Pro Ala Pro Glu Gly Cys Pro Trp 
            100                 105                 110         


Ser Cys Arg Leu Leu Gly Ile Gly Gly His Leu Ser Pro Gln Gly Lys 
        115                 120                 125             


Leu Xaa Leu Pro Glu Glu His Pro Cys Leu Lys Ala Pro Arg Leu Arg 
    130                 135                 140                 


Cys Gln Ser Cys Lys Leu Ala Gln Ala Pro Gly Leu Arg Ala Gly Glu 
145                 150                 155                 160 


Arg Ser Pro Glu Glu Ser Leu Gly Gly Arg Arg Lys Arg Asn Val Asn 
                165                 170                 175     


Xaa Ala Pro Gln Phe Gln Pro Pro Ser Tyr Gln Ala Xaa Val Pro Glu 
            180                 185                 190         


Asn Gln Pro Ala Gly Xaa Pro Val Ala Ser Leu Arg Ala Ile Asp Pro 
        195                 200                 205             


Asp Glu Gly Glu Ala Gly Arg Leu Glu Tyr Xaa Met Asp Ala Leu Phe 
    210                 215                 220                 


Asp Ser Arg Ser Asn Gln Phe Phe Ser Leu Asp Pro Val Xaa Gly Ala 
225                 230                 235                 240 


Val Xaa Xaa Ala Glu Glu Leu Asp Arg Glu Xaa Lys Ser Xaa His Val 
                245                 250                 255     


Phe Arg Val Xaa Ala Gln Asp His Gly Met Pro Arg Arg Ser Ala Leu 
            260                 265                 270         


Ala Xaa Leu Xaa Ile Leu Val Xaa Asp Xaa Asn Asp His Asp Pro Val 
        275                 280                 285             


Phe Glu Gln Gln Glu Tyr Lys Glu Ser Leu Arg Glu Asn Leu Glu Val 
    290                 295                 300                 


Gly Tyr Glu Val Leu Xaa Val Arg Ala Xaa Asp Gly Asp Ala Pro Pro 
305                 310                 315                 320 


Asn Ala Asn Ile Leu Tyr Arg Leu Leu Glu Gly Ser Gly Gly Ser Pro 
                325                 330                 335     


Ser Glu Val Phe Glu Ile Asp Pro Arg Ser Gly Val Ile Arg Xaa Arg 
            340                 345                 350         


Gly Pro Val Asp Arg Glu Glu Val Glu Ser Tyr Gln Leu Xaa Val Glu 
        355                 360                 365             


Ala Ser Asp Gln Gly Arg Asp Pro Gly Pro Arg Ser Xaa Xaa Ala Ala 
    370                 375                 380                 


Val Phe Leu Ser Val Glu Asp Asp Asn Asp Asn Ala Pro Gln Phe Ser 
385                 390                 395                 400 


Glu Lys Arg Tyr Val Val Gln Val Arg Glu Asp Val Xaa Pro Gly Ala 
                405                 410                 415     


Pro Val Leu Arg Val Xaa Ala Ser Asp Arg Asp Lys Gly Ser Asn Ala 
            420                 425                 430         


Val Val His Tyr Ser Ile Met Ser Gly Asn Ala Arg Gly Gln Phe Tyr 
        435                 440                 445             


Leu Asp Ala Gln Xaa Gly Ala Leu Asp Val Val Ser Pro Leu Asp Tyr 
    450                 455                 460                 


Glu Xaa Xaa Lys Glu Tyr Xaa Leu Arg Val Arg Ala Gln Asp Gly Gly 
465                 470                 475                 480 


Arg Pro Pro Leu Ser Asn Val Ser Gly Leu Val Xaa Val Gln Val Leu 
                485                 490                 495     


Asp Ile Asn Asp Asn Ala Pro Ile Phe Val Ser Xaa Pro Phe Gln Ala 
            500                 505                 510         


Xaa Val Leu Glu Ser Val Pro Leu Gly Tyr Leu Val Leu His Val Gln 
        515                 520                 525             


Ala Ile Asp Ala Asp Ala Gly Asp Asn Ala Arg Leu Glu Tyr Arg Leu 
    530                 535                 540                 


Ala Gly Val Gly His Asp Phe Pro Phe Xaa Ile Asn Asn Gly Xaa Gly 
545                 550                 555                 560 


Trp Ile Ser Val Ala Ala Glu Leu Asp Arg Glu Glu Val Asp Phe Tyr 
                565                 570                 575     


Ser Phe Gly Val Glu Ala Arg Asp His Gly Xaa Pro Ala Leu Xaa Ala 
            580                 585                 590         


Ser Ala Ser Val Ser Val Xaa Val Leu Asp Val Asn Asp Asn Asn Pro 
        595                 600                 605             


Xaa Phe Xaa Gln Pro Glu Tyr Xaa Val Arg Leu Asn Glu Asp Ala Ala 
    610                 615                 620                 


Val Gly Xaa Ser Val Val Xaa Val Ser Ala Val Asp Arg Asp Ala His 
625                 630                 635                 640 


Ser Val Ile Xaa Tyr Gln Ile Xaa Ser Gly Asn Xaa Arg Asn Arg Phe 
                645                 650                 655     


Ser Ile Xaa Ser Gln Ser Gly Gly Gly Leu Val Ser Leu Ala Leu Pro 
            660                 665                 670         


Leu Asp Tyr Lys Leu Glu Arg Gln Tyr Val Leu Ala Val Xaa Ala Ser 
        675                 680                 685             


Asp Gly Xaa Arg Gln Asp Xaa Ala Gln Ile Val Val Asn Val Xaa Asp 
    690                 695                 700                 


Ala Asn Xaa His Arg Pro Val Phe Gln Ser Ser His Tyr Xaa Val Asn 
705                 710                 715                 720 


Val Asn Glu Asp Arg Pro Ala Gly Xaa Xaa Val Val Leu Ile Ser Ala 
                725                 730                 735     


Xaa Asp Glu Asp Xaa Gly Glu Asn Ala Arg Ile Xaa Tyr Phe Met Glu 
            740                 745                 750         


Asp Ser Ile Pro Gln Phe Arg Ile Asp Ala Asp Xaa Gly Ala Val Xaa 
        755                 760                 765             


Xaa Gln Ala Glu Leu Asp Tyr Glu Asp Gln Val Ser Tyr Xaa Leu Ala 
    770                 775                 780                 


Ile Xaa Ala Arg Asp Asn Gly Ile Pro Gln Lys Ser Asp Xaa Xaa Tyr 
785                 790                 795                 800 


Leu Glu Ile Leu Val Asn Asp Val Asn Asp Asn Ala Pro Gln Phe Leu 
                805                 810                 815     


Arg Asp Ser Tyr Gln Gly Ser Val Tyr Glu Asp Val Pro Pro Phe Xaa 
            820                 825                 830         


Ser Val Leu Gln Ile Ser Ala Xaa Asp Arg Asp Ser Gly Leu Asn Gly 
        835                 840                 845             


Arg Val Phe Tyr Xaa Phe Gln Gly Gly Asp Asp Gly Asp Gly Asp Phe 
    850                 855                 860                 


Ile Val Glu Ser Xaa Ser Gly Ile Val Arg Xaa Leu Arg Arg Leu Asp 
865                 870                 875                 880 


Arg Glu Asn Val Ala Gln Tyr Val Leu Arg Ala Tyr Ala Val Asp Lys 
                885                 890                 895     


Gly Met Pro Pro Ala Arg Xaa Pro Met Glu Val Xaa Val Xaa Val Leu 
            900                 905                 910         


Asp Val Asn Asp Asn Pro Pro Val Phe Glu Gln Asp Glu Phe Asp Val 
        915                 920                 925             


Phe Val Glu Glu Asn Ser Pro Ile Gly Leu Ala Val Ala Arg Val Xaa 
    930                 935                 940                 


Ala Xaa Asp Pro Asp Glu Gly Xaa Asn Ala Gln Ile Met Tyr Gln Ile 
945                 950                 955                 960 


Val Glu Gly Asn Ile Pro Glu Val Phe Gln Leu Asp Ile Phe Ser Gly 
                965                 970                 975     


Glu Leu Xaa Ala Leu Val Asp Leu Asp Tyr Glu Asp Arg Pro Glu Tyr 
            980                 985                 990         


Val Leu Val Ile Gln Ala Xaa Ser  Ala Pro Leu Val Ser  Arg Ala Xaa 
        995                 1000                 1005             


Val His  Val Arg Leu Leu Asp  Arg Asn Asp Asn Pro  Pro Val Leu 
    1010                 1015                 1020             


Gly Asn  Phe Glu Ile Leu Phe  Asn Asn Tyr Val Xaa  Asn Arg Ser 
    1025                 1030                 1035             


Ser Ser  Phe Pro Gly Gly Ala  Ile Gly Arg Val Pro  Ala His Asp 
    1040                 1045                 1050             


Pro Asp  Ile Ser Asp Ser Leu  Xaa Tyr Ser Phe Glu  Arg Gly Asn 
    1055                 1060                 1065             


Glu Leu  Ser Leu Val Leu Leu  Asn Ala Ser Xaa Gly  Glu Leu Lys 
    1070                 1075                 1080             


Leu Ser  Arg Ala Leu Asp Asn  Asn Arg Pro Leu Glu  Ala Ile Met 
    1085                 1090                 1095             


Ser Val  Leu Val Ser Asp Gly  Val His Ser Val Xaa  Ala Gln Cys 
    1100                 1105                 1110             


Ala Leu  Arg Val Xaa Ile Ile  Xaa Asp Glu Met Leu  Xaa His Ser 
    1115                 1120                 1125             


Ile Xaa  Leu Arg Leu Glu Asp  Met Ser Pro Glu Arg  Phe Leu Ser 
    1130                 1135                 1140             


Pro Leu  Leu Gly Leu Phe Ile  Gln Ala Val Ala Ala  Xaa Leu Ala 
    1145                 1150                 1155             


Xaa Pro  Pro Asp His Val Val  Val Phe Asn Val Gln  Arg Asp Xaa 
    1160                 1165                 1170             


Asp Ala  Pro Gly Gly His Ile  Leu Asn Val Ser Leu  Ser Val Gly 
    1175                 1180                 1185             


Gln Pro  Pro Gly Pro Gly Gly  Gly Pro Pro Phe Leu  Pro Ser Glu 
    1190                 1195                 1200             


Asp Leu  Gln Glu Arg Leu Tyr  Leu Asn Arg Ser Leu  Leu Xaa Ala 
    1205                 1210                 1215             


Ile Ser  Ala Gln Arg Val Leu  Pro Phe Asp Asp Asn  Ile Cys Leu 
    1220                 1225                 1230             


Arg Glu  Pro Cys Glu Asn Tyr  Met Arg Cys Val Ser  Val Leu Arg 
    1235                 1240                 1245             


Phe Asp  Ser Ser Ala Pro Phe  Ile Ala Ser Ser Ser  Val Leu Phe 
    1250                 1255                 1260             


Arg Pro  Ile His Pro Val Gly  Gly Leu Arg Cys Arg  Cys Pro Pro 
    1265                 1270                 1275             


Gly Phe  Xaa Gly Asp Tyr Cys  Glu Xaa Glu Val Asp  Leu Cys Tyr 
    1280                 1285                 1290             


Ser Arg  Pro Cys Gly Pro His  Gly Arg Cys Arg Ser  Arg Glu Gly 
    1295                 1300                 1305             


Gly Tyr  Xaa Cys Leu Cys Arg  Asp Gly Tyr Xaa Gly  Glu His Cys 
    1310                 1315                 1320             


Glu Val  Ser Ala Arg Ser Gly  Arg Cys Xaa Pro Gly  Val Cys Lys 
    1325                 1330                 1335             


Asn Gly  Gly Xaa Cys Val Asn  Leu Leu Val Gly Gly  Phe Lys Cys 
    1340                 1345                 1350             


Asp Cys  Pro Ser Gly Asp Phe  Glu Lys Pro Tyr Cys  Gln Val Xaa 
    1355                 1360                 1365             


Xaa Arg  Ser Phe Pro Ala His  Ser Phe Ile Xaa Phe  Arg Gly Leu 
    1370                 1375                 1380             


Arg Gln  Arg Phe His Phe Xaa  Leu Ala Leu Ser Phe  Ala Xaa Lys 
    1385                 1390                 1395             


Glu Arg  Asp Gly Leu Leu Leu  Tyr Asn Gly Arg Phe  Asn Glu Lys 
    1400                 1405                 1410             


His Asp  Phe Val Ala Leu Glu  Val Ile Gln Glu Gln  Val Gln Leu 
    1415                 1420                 1425             


Xaa Phe  Ser Ala Gly Glu Ser  Xaa Xaa Xaa Val Ser  Pro Phe Val 
    1430                 1435                 1440             


Pro Gly  Gly Val Ser Asp Gly  Gln Trp His Xaa Val  Gln Leu Lys 
    1445                 1450                 1455             


Tyr Tyr  Asn Lys Pro Leu Leu  Gly Gln Xaa Gly Leu  Pro Gln Gly 
    1460                 1465                 1470             


Pro Ser  Glu Gln Lys Val Ala  Val Val Xaa Val Asp  Gly Cys Asp 
    1475                 1480                 1485             


Xaa Gly  Val Ala Leu Arg Phe  Gly Ser Val Leu Gly  Asn Tyr Ser 
    1490                 1495                 1500             


Cys Ala  Ala Gln Gly Xaa Gln  Gly Gly Ser Lys Lys  Ser Leu Asp 
    1505                 1510                 1515             


Leu Xaa  Gly Pro Leu Leu Leu  Gly Gly Val Pro Asp  Leu Pro Glu 
    1520                 1525                 1530             


Ser Phe  Pro Val Arg Met Arg  Gln Phe Val Gly Cys  Met Arg Asn 
    1535                 1540                 1545             


Leu Gln  Val Asp Ser Arg His  Ile Asp Met Ala Asp  Phe Ile Ala 
    1550                 1555                 1560             


Asn Asn  Gly Xaa Val Pro Gly  Cys Pro Ala Lys Lys  Asn Val Cys 
    1565                 1570                 1575             


Asp Ser  Asn Xaa Cys His Asn  Gly Gly Xaa Cys Val  Asn Gln Trp 
    1580                 1585                 1590             


Asp Ala  Phe Ser Cys Glu Cys  Pro Leu Gly Phe Gly  Gly Lys Ser 
    1595                 1600                 1605             


Cys Ala  Gln Glu Met Ala Asn  Pro Gln His Phe Leu  Gly Ser Ser 
    1610                 1615                 1620             


Leu Val  Ala Trp His Gly Leu  Ser Leu Pro Ile Ser  Gln Pro Trp 
    1625                 1630                 1635             


Tyr Leu  Ser Leu Met Phe Arg  Xaa Arg Gln Ala Asp  Gly Val Leu 
    1640                 1645                 1650             


Leu Gln  Ala Ile Xaa Arg Gly  Arg Ser Xaa Ile Xaa  Leu Gln Leu 
    1655                 1660                 1665             


Arg Glu  Gly His Val Met Leu  Ser Val Glu Gly Xaa  Gly Leu Gln 
    1670                 1675                 1680             


Ala Ser  Ser Leu Arg Leu Glu  Pro Gly Arg Ala Asn  Asp Gly Asp 
    1685                 1690                 1695             


Trp His  His Ala Gln Leu Ala  Leu Gly Ala Ser Gly  Gly Pro Gly 
    1700                 1705                 1710             


His Ala  Ile Leu Ser Phe Asp  Tyr Gly Gln Gln Arg  Ala Glu Gly 
    1715                 1720                 1725             


Asn Leu  Gly Pro Arg Leu His  Gly Leu His Leu Ser  Asn Ile Xaa 
    1730                 1735                 1740             


Val Gly  Gly Ile Pro Gly Pro  Ala Gly Gly Val Ala  Arg Gly Phe 
    1745                 1750                 1755             


Arg Gly  Cys Leu Gln Gly Val  Arg Val Ser Asp Xaa  Pro Glu Gly 
    1760                 1765                 1770             


Val Asn  Ser Leu Asp Pro Ser  His Gly Glu Ser Ile  Asn Val Glu 
    1775                 1780                 1785             


Gln Gly  Cys Ser Leu Pro Asp  Pro Cys Asp Ser Asn  Pro Cys Pro 
    1790                 1795                 1800             


Ala Asn  Ser Tyr Cys Ser Asn  Asp Trp Asp Ser Tyr  Ser Cys Ser 
    1805                 1810                 1815             


Cys Asp  Pro Gly Tyr Tyr Gly  Asp Asn Cys Xaa Asn  Val Cys Asp 
    1820                 1825                 1830             


Leu Asn  Pro Cys Glu His Gln  Ser Val Cys Xaa Arg  Lys Pro Ser 
    1835                 1840                 1845             


Ala Pro  His Gly Tyr Xaa Cys  Glu Cys Pro Pro Asn  Tyr Leu Gly 
    1850                 1855                 1860             


Pro Tyr  Cys Glu Xaa Arg Ile  Asp Gln Pro Cys Pro  Arg Gly Trp 
    1865                 1870                 1875             


Trp Gly  His Pro Xaa Cys Gly  Pro Cys Asn Cys Asp  Val Ser Lys 
    1880                 1885                 1890             


Gly Phe  Asp Pro Asp Cys Asn  Lys Xaa Ser Gly Glu  Cys His Cys 
    1895                 1900                 1905             


Lys Glu  Asn His Tyr Arg Pro  Pro Gly Ser Pro Xaa  Cys Leu Leu 
    1910                 1915                 1920             


Cys Asp  Cys Tyr Pro Xaa Gly  Ser Leu Ser Arg Val  Cys Asp Pro 
    1925                 1930                 1935             


Glu Asp  Gly Gln Cys Pro Cys  Lys Pro Gly Val Ile  Gly Arg Gln 
    1940                 1945                 1950             


Cys Asp  Arg Cys Asp Asn Pro  Phe Ala Glu Val Xaa  Xaa Asn Gly 
    1955                 1960                 1965             


Cys Glu  Val Asn Tyr Asp Ser  Cys Pro Arg Ala Ile  Glu Ala Gly 
    1970                 1975                 1980             


Ile Trp  Trp Pro Arg Xaa Arg  Phe Gly Leu Pro Ala  Ala Ala Pro 
    1985                 1990                 1995             


Cys Pro  Lys Gly Ser Phe Gly  Xaa Ala Val Arg His  Cys Asp Glu 
    2000                 2005                 2010             


His Arg  Gly Trp Leu Pro Pro  Asn Leu Phe Asn Cys  Xaa Ser Ile 
    2015                 2020                 2025             


Xaa Phe  Ser Glu Leu Lys Gly  Phe Ala Glu Arg Leu  Gln Arg Asn 
    2030                 2035                 2040             


Glu Ser  Gly Leu Asp Ser Gly  Arg Ser Gln Gln Leu  Ala Leu Leu 
    2045                 2050                 2055             


Leu Arg  Asn Ala Xaa Gln His  Xaa Ala Gly Tyr Phe  Gly Ser Asp 
    2060                 2065                 2070             


Val Lys  Val Ala Tyr Gln Leu  Ala Xaa Arg Leu Leu  Ala His Glu 
    2075                 2080                 2085             


Ser Xaa  Gln Arg Gly Phe Gly  Leu Ser Ala Xaa Gln  Asp Val His 
    2090                 2095                 2100             


Phe Xaa  Glu Asn Leu Leu Arg  Val Gly Ser Ala Leu  Leu Asp Xaa 
    2105                 2110                 2115             


Ala Asn  Lys Arg His Trp Glu  Leu Ile Gln Gln Xaa  Glu Gly Gly 
    2120                 2125                 2130             


Xaa Ala  Trp Leu Leu Gln His  Tyr Glu Ala Tyr Ala  Ser Ala Leu 
    2135                 2140                 2145             


Ala Gln  Asn Met Arg His Xaa  Tyr Leu Ser Pro Phe  Xaa Ile Val 
    2150                 2155                 2160             


Xaa Pro  Asn Ile Val Ile Ser  Val Val Arg Leu Asp  Lys Gly Asn 
    2165                 2170                 2175             


Phe Ala  Gly Ala Lys Leu Pro  Arg Tyr Glu Ala Leu  Arg Gly Glu 
    2180                 2185                 2190             


Gln Pro  Pro Asp Leu Glu Xaa  Xaa Val Ile Leu Pro  Glu Ser Val 
    2195                 2200                 2205             


Phe Arg  Glu Xaa Pro Pro Val  Val Arg Pro Ala Gly  Pro Gly Glu 
    2210                 2215                 2220             


Ala Gln  Glu Pro Glu Glu Leu  Ala Arg Arg Gln Arg  Arg His Pro 
    2225                 2230                 2235             


Glu Leu  Ser Gln Gly Glu Ala  Val Ala Ser Val Ile  Ile Tyr Arg 
    2240                 2245                 2250             


Xaa Leu  Ala Gly Leu Leu Pro  His Asn Tyr Asp Pro  Asp Lys Arg 
    2255                 2260                 2265             


Ser Leu  Arg Val Pro Lys Arg  Pro Ile Ile Asn Xaa  Pro Val Val 
    2270                 2275                 2280             


Ser Ile  Ser Val His Asp Asp  Glu Glu Leu Leu Pro  Arg Ala Leu 
    2285                 2290                 2295             


Asp Lys  Pro Val Xaa Val Gln  Phe Arg Leu Leu Glu  Xaa Glu Glu 
    2300                 2305                 2310             


Arg Xaa  Lys Pro Ile Cys Val  Phe Trp Asn His Ser  Ile Leu Val 
    2315                 2320                 2325             


Ser Gly  Xaa Gly Gly Trp Ser  Ala Arg Gly Cys Glu  Val Val Phe 
    2330                 2335                 2340             


Arg Asn  Glu Ser His Val Ser  Cys Gln Cys Asn His  Met Xaa Ser 
    2345                 2350                 2355             


Phe Ala  Val Leu Met Asp Val  Ser Arg Arg Glu Asn  Gly Glu Ile 
    2360                 2365                 2370             


Leu Pro  Leu Lys Xaa Leu Xaa  Tyr Val Ala Leu Gly  Val Xaa Leu 
    2375                 2380                 2385             


Ala Ala  Leu Leu Leu Xaa Phe  Phe Phe Leu Xaa Leu  Leu Arg Ile 
    2390                 2395                 2400             


Leu Arg  Ser Asn Gln His Gly  Ile Arg Arg Asn Leu  Xaa Ala Ala 
    2405                 2410                 2415             


Leu Gly  Leu Ala Gln Leu Val  Phe Leu Leu Gly Ile  Asn Gln Ala 
    2420                 2425                 2430             


Asp Leu  Pro Phe Ala Cys Xaa  Val Ile Ala Ile Leu  Leu His Phe 
    2435                 2440                 2445             


Leu Tyr  Leu Cys Xaa Phe Ser  Trp Ala Leu Leu Glu  Ala Leu His 
    2450                 2455                 2460             


Leu Tyr  Arg Ala Leu Xaa Glu  Val Arg Asp Val Asn  Xaa Gly Pro 
    2465                 2470                 2475             


Met Arg  Phe Tyr Tyr Met Leu  Gly Trp Gly Val Pro  Ala Phe Ile 
    2480                 2485                 2490             


Xaa Gly  Leu Ala Val Gly Leu  Asp Pro Glu Gly Tyr  Gly Asn Pro 
    2495                 2500                 2505             


Asp Phe  Cys Trp Leu Ser Ile  Tyr Asp Xaa Leu Ile  Trp Ser Phe 
    2510                 2515                 2520             


Ala Gly  Pro Val Ala Phe Ala  Val Ser Met Ser Val  Phe Leu Tyr 
    2525                 2530                 2535             


Ile Leu  Ala Ala Arg Ala Ser  Cys Ala Ala Gln Arg  Gln Gly Phe 
    2540                 2545                 2550             


Glu Lys  Lys Gly Pro Val Ser  Gly Leu Gln Pro Ser  Phe Ala Val 
    2555                 2560                 2565             


Leu Leu  Leu Leu Ser Ala Xaa  Trp Leu Leu Ala Leu  Leu Ser Val 
    2570                 2575                 2580             


Asn Ser  Asp Xaa Leu Leu Phe  His Tyr Leu Phe Ala  Xaa Cys Asn 
    2585                 2590                 2595             


Cys Ile  Gln Gly Pro Phe Ile  Phe Leu Ser Tyr Val  Val Leu Ser 
    2600                 2605                 2610             


Lys Glu  Val Arg Lys Ala Leu  Lys Leu Ala Cys Ser  Arg Lys Pro 
    2615                 2620                 2625             


Ser Pro  Asp Pro Ala Leu Xaa  Xaa Lys Ser Xaa Leu  Xaa Ser Ser 
    2630                 2635                 2640             


Tyr Asn  Cys Pro Ser Pro Tyr  Ala Asp Gly Arg Leu  Tyr Gln Pro 
    2645                 2650                 2655             


Tyr Gly  Asp Ser Ala Gly Ser  Leu His Ser Xaa Ser  Arg Ser Gly 
    2660                 2665                 2670             


Lys Ser  Gln Pro Ser Tyr Ile  Pro Phe Leu Leu Arg  Glu Glu Ser 
    2675                 2680                 2685             


Ala Leu  Asn Pro Gly Gln Gly  Pro Pro Gly Leu Gly  Asp Pro Gly 
    2690                 2695                 2700             


Ser Leu  Phe Leu Glu Gly Gln  Asp Gln Gln His Asp  Pro Asp Xaa 
    2705                 2710                 2715             


Asp Ser  Asp Ser Asp Leu Ser  Leu Glu Asp Asp Gln  Ser Gly Ser 
    2720                 2725                 2730             


Tyr Ala  Ser Xaa His Ser Ser  Asp Ser Glu Glu Glu  Glu Glu Glu 
    2735                 2740                 2745             


Glu Glu  Glu Glu Ala Ala Phe  Pro Gly Glu Gln Gly  Trp Asp Ser 
    2750                 2755                 2760             


Leu Leu  Gly Pro Gly Ala Glu  Arg Leu Pro Leu His  Ser Xaa Pro 
    2765                 2770                 2775             


Lys Asp  Gly Gly Pro Gly Pro  Gly Lys Ala Pro Trp  Pro Gly Asp 
    2780                 2785                 2790             


Phe Gly  Xaa Xaa Ala Lys Glu  Ser Ser Gly Asn Gly  Ala Pro Glu 
    2795                 2800                 2805             


Glu Arg  Leu Arg Glu Asn Gly  Asp Ala Leu Ser Arg  Glu Gly Ser 
    2810                 2815                 2820             


Leu Gly  Pro Leu Pro Gly Ser  Ser Ala Gln Pro His  Lys Gly Ile 
    2825                 2830                 2835             


Leu Lys  Lys Lys Cys Leu Pro  Xaa Ile Ser Glu Lys  Ser Ser Leu 
    2840                 2845                 2850             


Leu Arg  Leu Pro Leu Glu Gln  Cys Xaa Gly Ser Ser  Arg Gly Ser 
    2855                 2860                 2865             


Ser Ala  Ser Glu Gly Ser Arg  Gly Gly Pro Pro Pro  Arg Pro Pro 
    2870                 2875                 2880             


Pro Arg  Gln Ser Leu Gln Glu  Gln Leu Asn Gly Val  Met Pro Ile 
    2885                 2890                 2895             


Ala Met  Ser Ile Lys Ala Gly  Xaa Val Asp Glu Asp  Ser Ser Gly 
    2900                 2905                 2910             


Ser Glu  Phe Leu Phe Phe Asn  Phe Leu His 
    2915                 2920             


<210> 5846
<211> 3312
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1145)..(1145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1224)..(1224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1247)..(1247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1267)..(1267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1276)..(1276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1319)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1324)..(1324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1428)..(1428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1458)..(1458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1466)..(1466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1474)..(1474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1489)..(1489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1491)..(1491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1538)..(1538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1577)..(1577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1580)..(1580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1585)..(1585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1590)..(1590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1602)..(1602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1613)..(1613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1659)..(1659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1668)..(1668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1715)..(1715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1772)..(1772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1795)..(1795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1798)..(1798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1812)..(1812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1825)..(1825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1827)..(1827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1842)..(1842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1880)..(1880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1924)..(1924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1947)..(1947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1967)..(1967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1971)..(1971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2007)..(2007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2036)..(2036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2055)..(2055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2085)..(2085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2118)..(2118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2142)..(2142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2149)..(2149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2179)..(2179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2198)..(2198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2202)..(2202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2216)..(2216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2219)..(2219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2230)..(2230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2250)..(2250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2252)..(2252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2273)..(2273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2304)..(2304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2312)..(2312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2321)..(2321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2361)..(2361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2380)..(2380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2388)..(2389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2415)..(2415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2472)..(2472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2496)..(2496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2517)..(2517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2519)..(2519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2543)..(2543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2557)..(2557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2596)..(2596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2603)..(2603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2616)..(2616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2699)..(2699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2707)..(2707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2711)..(2711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2719)..(2719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2723)..(2723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2810)..(2810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2822)..(2822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2827)..(2827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2839)..(2839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2866)..(2866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2877)..(2877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2919)..(2919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2938)..(2938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2967)..(2967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2978)..(2978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2993)..(2993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2998)..(2998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3023)..(3023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3036)..(3036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3056)..(3056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3120)..(3120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3155)..(3155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3162)..(3162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3240)..(3240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3266)..(3266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3272)..(3273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3275)..(3275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3279)..(3279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3287)..(3287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (3292)..(3292)
<223> Selenocysteine

<400> 5846
Met Met Ala Arg Arg Pro Pro Trp Arg Gly Leu Gly Gly Arg Ser Xaa 
1               5                   10                  15      


Pro Ile Leu Leu Leu Leu Leu Leu Ser Leu Phe Pro Leu Ser Gln Glu 
            20                  25                  30          


Glu Leu Gly Gly Gly Gly His Gln Gly Trp Asp Pro Gly Leu Ala Ala 
        35                  40                  45              


Xaa Xaa Gly Pro Arg Ala His Ile Gly Gly Gly Ala Leu Ala Leu Cys 
    50                  55                  60                  


Pro Glu Ser Ser Gly Val Arg Glu Asp Gly Gly Pro Gly Leu Gly Val 
65                  70                  75                  80  


Arg Glu Pro Ile Phe Val Gly Leu Arg Gly Arg Arg Gln Ser Ala Arg 
                85                  90                  95      


Asn Ser Arg Gly Pro Pro Glu Gln Pro Asn Glu Glu Leu Gly Ile Glu 
            100                 105                 110         


His Gly Val Gln Pro Leu Gly Ser Arg Glu Arg Glu Xaa Gly Gln Gly 
        115                 120                 125             


Pro Gly Ser Val Leu Tyr Trp Arg Pro Glu Val Ser Ser Cys Gly Arg 
    130                 135                 140                 


Xaa Gly Pro Leu Gln Arg Gly Ser Leu Ser Pro Gly Ala Leu Ser Ser 
145                 150                 155                 160 


Gly Val Pro Gly Ser Gly Asn Ser Ser Pro Leu Pro Ser Asp Phe Leu 
                165                 170                 175     


Ile Arg His His Gly Pro Lys Pro Val Ser Ser Gln Arg Asn Ala Gly 
            180                 185                 190         


Xaa Gly Ser Arg Lys Arg Val Gly Xaa Ala Arg Cys Cys Gly Glu Leu 
        195                 200                 205             


Trp Ala Xaa Gly Ser Lys Gly Gln Gly Glu Arg Ala Xaa Xaa Ser Gly 
    210                 215                 220                 


Ala Glu Arg Xaa Ala Pro Arg Arg Asn Cys Leu Pro Gly Ala Ser Gly 
225                 230                 235                 240 


Ser Gly Pro Glu Leu Asp Ser Ala Pro Arg Xaa Ala Arg Xaa Ala Pro 
                245                 250                 255     


Ala Ser Gly Ser Ala Pro Arg Glu Ser Arg Xaa Ala Pro Glu Pro Ala 
            260                 265                 270         


Pro Lys Arg Met Arg Ser Arg Gly Leu Phe Arg Cys Arg Phe Leu Pro 
        275                 280                 285             


Gln Arg Pro Gly Pro Arg Pro Pro Gly Leu Pro Ala Arg Pro Glu Ala 
    290                 295                 300                 


Arg Lys Val Xaa Ser Ala Asn Arg Ala Arg Phe Arg Arg Ala Ala Asn 
305                 310                 315                 320 


Arg His Pro Gln Phe Pro Gln Tyr Asn Tyr Gln Xaa Leu Val Pro Glu 
                325                 330                 335     


Asn Glu Ala Ala Gly Xaa Ala Val Leu Arg Val Val Ala Gln Asp Pro 
            340                 345                 350         


Asp Ala Gly Glu Ala Gly Arg Leu Val Tyr Ser Leu Ala Ala Leu Met 
        355                 360                 365             


Asn Ser Arg Ser Leu Glu Leu Phe Ser Ile Asp Pro Gln Ser Gly Leu 
    370                 375                 380                 


Ile Arg Xaa Ala Ala Ala Leu Asp Arg Glu Ser Met Glu Arg His Tyr 
385                 390                 395                 400 


Leu Arg Val Xaa Ala Gln Asp His Gly Ser Pro Arg Leu Ser Ala Xaa 
                405                 410                 415     


Xaa Met Val Ala Val Xaa Val Ala Asp Arg Asn Asp His Ser Pro Val 
            420                 425                 430         


Phe Glu Gln Ala Gln Tyr Arg Glu Xaa Leu Arg Glu Asn Val Glu Glu 
        435                 440                 445             


Gly Tyr Pro Ile Leu Gln Leu Arg Ala Xaa Asp Gly Asp Ala Pro Pro 
    450                 455                 460                 


Asn Ala Asn Leu Arg Tyr Arg Phe Val Gly Pro Pro Ala Ala Arg Ala 
465                 470                 475                 480 


Ala Ala Ala Ala Ala Phe Glu Ile Asp Pro Arg Ser Gly Leu Ile Ser 
                485                 490                 495     


Xaa Ser Gly Arg Val Asp Arg Glu His Met Glu Ser Tyr Glu Leu Val 
            500                 505                 510         


Val Glu Ala Ser Asp Gln Gly Gln Glu Pro Gly Pro Arg Ser Ala Xaa 
        515                 520                 525             


Val Arg Val His Ile Xaa Val Leu Asp Glu Asn Asp Asn Ala Pro Gln 
    530                 535                 540                 


Phe Ser Glu Lys Arg Tyr Val Ala Gln Val Arg Glu Asp Val Arg Pro 
545                 550                 555                 560 


His Xaa Val Val Leu Arg Val Xaa Ala Xaa Asp Arg Asp Lys Asp Ala 
                565                 570                 575     


Asn Gly Leu Val His Tyr Asn Ile Ile Ser Gly Asn Ser Arg Gly His 
            580                 585                 590         


Phe Ala Ile Asp Ser Leu Xaa Gly Glu Ile Gln Val Val Ala Pro Leu 
        595                 600                 605             


Asp Phe Glu Ala Glu Arg Glu Tyr Ala Leu Arg Ile Arg Ala Gln Asp 
    610                 615                 620                 


Ala Gly Arg Pro Pro Leu Ser Asn Asn Xaa Gly Leu Ala Ser Ile Gln 
625                 630                 635                 640 


Val Val Asp Ile Asn Asp His Ile Pro Ile Phe Val Ser Xaa Pro Phe 
                645                 650                 655     


Gln Val Ser Val Leu Glu Asn Ala Pro Leu Gly His Ser Val Ile His 
            660                 665                 670         


Ile Gln Ala Val Asp Ala Asp His Gly Glu Asn Ala Arg Leu Glu Tyr 
        675                 680                 685             


Ser Leu Xaa Gly Val Ala Pro Asp Xaa Pro Phe Val Ile Asn Ser Ala 
    690                 695                 700                 


Xaa Gly Trp Val Ser Val Ser Gly Pro Leu Asp Arg Glu Ser Val Glu 
705                 710                 715                 720 


His Tyr Phe Phe Gly Val Glu Ala Arg Asp His Gly Ser Pro Pro Leu 
                725                 730                 735     


Ser Ala Ser Ala Ser Val Xaa Val Xaa Val Leu Asp Val Asn Asp Asn 
            740                 745                 750         


Arg Pro Glu Phe Xaa Met Lys Glu Tyr His Leu Arg Leu Asn Glu Asp 
        755                 760                 765             


Ala Ala Val Gly Xaa Ser Val Val Ser Val Xaa Ala Val Asp Arg Asp 
    770                 775                 780                 


Ala Asn Ser Ala Ile Ser Tyr Gln Ile Xaa Gly Gly Asn Xaa Arg Asn 
785                 790                 795                 800 


Arg Phe Ala Ile Ser Xaa Gln Gly Gly Val Gly Leu Val Xaa Leu Ala 
                805                 810                 815     


Leu Pro Leu Asp Tyr Lys Gln Glu Arg Tyr Phe Lys Leu Val Leu Xaa 
            820                 825                 830         


Ala Ser Asp Arg Ala Leu His Asp His Cys Tyr Val His Ile Asn Ile 
        835                 840                 845             


Xaa Asp Ala Asn Xaa His Arg Pro Val Phe Gln Ser Ala His Tyr Ser 
    850                 855                 860                 


Val Ser Val Asn Glu Asp Arg Pro Met Gly Ser Xaa Ile Val Val Ile 
865                 870                 875                 880 


Ser Ala Ser Asp Asp Asp Val Gly Glu Asn Ala Arg Ile Xaa Tyr Leu 
                885                 890                 895     


Leu Glu Asp Asn Leu Pro Gln Phe Arg Ile Asp Ala Asp Ser Gly Ala 
            900                 905                 910         


Ile Xaa Leu Gln Ala Pro Leu Asp Tyr Glu Asp Gln Val Xaa Tyr Xaa 
        915                 920                 925             


Leu Ala Ile Xaa Ala Arg Asp Asn Gly Ile Pro Gln Lys Ala Asp Xaa 
    930                 935                 940                 


Xaa Tyr Val Glu Val Met Val Asn Asp Val Asn Asp Asn Ala Pro Gln 
945                 950                 955                 960 


Phe Val Ala Ser His Tyr Xaa Gly Leu Val Ser Glu Asp Ala Pro Pro 
                965                 970                 975     


Phe Xaa Ser Val Leu Gln Ile Ser Ala Xaa Asp Arg Asp Ala His Ala 
            980                 985                 990         


Asn Gly Arg Val Gln Tyr Xaa Phe  Gln Asn Gly Glu Asp  Gly Asp Gly 
        995                 1000                 1005             


Asp Phe  Xaa Ile Glu Pro Xaa  Ser Gly Ile Val Arg  Xaa Val Arg 
    1010                 1015                 1020             


Arg Leu  Asp Arg Glu Ala Val  Ser Val Tyr Glu Leu  Xaa Ala Tyr 
    1025                 1030                 1035             


Ala Val  Asp Arg Gly Val Pro  Pro Leu Arg Xaa Pro  Val Ser Ile 
    1040                 1045                 1050             


Gln Val  Met Val Gln Asp Val  Asn Asp Asn Ala Pro  Val Phe Pro 
    1055                 1060                 1065             


Ala Glu  Glu Phe Glu Val Arg  Val Lys Glu Asn Ser  Ile Val Gly 
    1070                 1075                 1080             


Ser Val  Val Ala Gln Ile Xaa  Ala Val Asp Pro Asp  Glu Gly Pro 
    1085                 1090                 1095             


Asn Ala  His Ile Met Tyr Gln  Ile Val Glu Gly Asn  Ile Pro Glu 
    1100                 1105                 1110             


Leu Phe  Gln Met Asp Ile Phe  Ser Gly Glu Leu Xaa  Ala Leu Ile 
    1115                 1120                 1125             


Asp Leu  Asp Tyr Glu Ala Arg  Gln Glu Tyr Val Ile  Val Val Gln 
    1130                 1135                 1140             


Ala Xaa  Ser Ala Pro Leu Val  Ser Arg Ala Xaa Val  His Val Arg 
    1145                 1150                 1155             


Leu Val  Asp Gln Asn Asp Asn  Ser Pro Val Leu Asn  Asn Phe Gln 
    1160                 1165                 1170             


Ile Leu  Phe Asn Asn Tyr Val  Ser Asn Arg Ser Asp  Xaa Phe Pro 
    1175                 1180                 1185             


Ser Gly  Ile Ile Gly Arg Ile  Pro Ala Tyr Asp Pro  Asp Val Ser 
    1190                 1195                 1200             


Asp His  Leu Phe Tyr Ser Phe  Glu Arg Gly Asn Glu  Leu Gln Leu 
    1205                 1210                 1215             


Leu Val  Val Asn Gln Xaa Ser  Gly Glu Leu Arg Leu  Ser Arg Lys 
    1220                 1225                 1230             


Leu Asp  Asn Asn Arg Pro Leu  Val Ala Ser Met Leu  Val Xaa Val 
    1235                 1240                 1245             


Xaa Asp  Gly Leu His Ser Val  Xaa Ala Gln Cys Val  Leu Arg Val 
    1250                 1255                 1260             


Val Ile  Ile Xaa Glu Glu Leu  Leu Ala Asn Ser Leu  Xaa Val Arg 
    1265                 1270                 1275             


Leu Glu  Asn Met Trp Gln Glu  Arg Phe Leu Ser Pro  Leu Leu Gly 
    1280                 1285                 1290             


Arg Phe  Leu Glu Gly Val Ala  Ala Val Leu Ala Xaa  Pro Ala Glu 
    1295                 1300                 1305             


Asp Val  Phe Ile Phe Asn Ile  Gln Asn Asp Xaa Asp  Val Gly Gly 
    1310                 1315                 1320             


Xaa Val  Leu Asn Val Ser Phe  Ser Ala Leu Ala Pro  Arg Gly Ala 
    1325                 1330                 1335             


Gly Ala  Gly Ala Ala Gly Pro  Trp Phe Ser Ser Glu  Glu Leu Gln 
    1340                 1345                 1350             


Glu Gln  Leu Tyr Val Arg Arg  Ala Ala Leu Ala Ala  Arg Ser Leu 
    1355                 1360                 1365             


Leu Asp  Val Leu Pro Phe Asp  Asp Asn Val Cys Leu  Arg Glu Pro 
    1370                 1375                 1380             


Cys Glu  Asn Tyr Met Lys Cys  Val Ser Val Leu Arg  Phe Asp Ser 
    1385                 1390                 1395             


Ser Ala  Pro Phe Leu Ala Ser  Ala Ser Xaa Leu Phe  Arg Pro Ile 
    1400                 1405                 1410             


Gln Pro  Ile Ala Gly Leu Arg  Cys Arg Cys Pro Pro  Gly Phe Xaa 
    1415                 1420                 1425             


Gly Asp  Phe Cys Glu Xaa Glu  Leu Asp Leu Cys Tyr  Ser Asn Pro 
    1430                 1435                 1440             


Cys Arg  Asn Gly Gly Ala Cys  Ala Arg Arg Glu Gly  Gly Tyr Xaa 
    1445                 1450                 1455             


Cys Val  Cys Arg Pro Arg Phe  Xaa Gly Glu Asp Cys  Glu Leu Asp 
    1460                 1465                 1470             


Xaa Glu  Ala Gly Arg Cys Val  Pro Gly Val Cys Arg  Asn Gly Gly 
    1475                 1480                 1485             


Xaa Cys  Xaa Asp Ala Pro Asn  Gly Gly Phe Arg Cys  Gln Cys Pro 
    1490                 1495                 1500             


Ala Gly  Gly Ala Phe Glu Gly  Pro Arg Cys Glu Val  Ala Ala Arg 
    1505                 1510                 1515             


Ser Phe  Pro Pro Ser Ser Phe  Val Met Phe Arg Gly  Leu Arg Gln 
    1520                 1525                 1530             


Arg Phe  His Leu Xaa Leu Ser  Leu Ser Phe Ala Xaa  Val Gln Gln 
    1535                 1540                 1545             


Ser Gly  Leu Leu Phe Tyr Asn  Gly Arg Leu Asn Glu  Lys His Asp 
    1550                 1555                 1560             


Phe Leu  Ala Leu Glu Leu Val  Ala Gly Gln Val Arg  Leu Xaa Tyr 
    1565                 1570                 1575             


Ser Xaa  Gly Glu Ser Asn Xaa  Val Val Ser Pro Xaa  Val Pro Gly 
    1580                 1585                 1590             


Gly Leu  Ser Asp Gly Gln Trp  His Xaa Val His Leu  Arg Tyr Tyr 
    1595                 1600                 1605             


Asn Lys  Pro Arg Xaa Asp Ala  Leu Gly Gly Ala Gln  Gly Pro Ser 
    1610                 1615                 1620             


Lys Asp  Lys Val Ala Val Leu  Ser Val Asp Asp Cys  Asp Val Ala 
    1625                 1630                 1635             


Val Ala  Leu Gln Phe Gly Ala  Glu Ile Gly Asn Tyr  Ser Cys Ala 
    1640                 1645                 1650             


Ala Ala  Gly Val Gln Xaa Ser  Ser Lys Lys Ser Leu  Asp Leu Xaa 
    1655                 1660                 1665             


Gly Pro  Leu Leu Leu Gly Gly  Val Pro Asn Leu Pro  Glu Asn Phe 
    1670                 1675                 1680             


Pro Val  Ser His Lys Asp Phe  Ile Gly Cys Met Arg  Asp Leu His 
    1685                 1690                 1695             


Ile Asp  Gly Arg Arg Val Asp  Met Ala Ala Phe Val  Ala Asn Asn 
    1700                 1705                 1710             


Gly Xaa  Met Ala Gly Cys Gln  Ala Lys Leu His Phe  Cys Asp Ser 
    1715                 1720                 1725             


Gly Pro  Cys Lys Asn Ser Gly  Phe Cys Ser Glu Arg  Trp Gly Ser 
    1730                 1735                 1740             


Phe Ser  Cys Asp Cys Pro Val  Gly Phe Gly Gly Lys  Asp Cys Gln 
    1745                 1750                 1755             


Leu Xaa  Met Ala His Pro His  His Phe Arg Gly Asn  Gly Xaa Leu 
    1760                 1765                 1770             


Ser Trp  Asn Phe Gly Ser Asp  Met Ala Val Ser Val  Pro Trp Tyr 
    1775                 1780                 1785             


Leu Gly  Leu Ala Phe Arg Xaa  Arg Ala Xaa Gln Gly  Val Leu Met 
    1790                 1795                 1800             


Gln Val  Gln Ala Gly Pro His  Ser Xaa Leu Leu Cys  Gln Leu Asp 
    1805                 1810                 1815             


Arg Gly  Leu Leu Ser Val Xaa  Val Xaa Arg Gly Ser  Gly Arg Ala 
    1820                 1825                 1830             


Ser His  Leu Leu Leu Asp Gln  Val Xaa Val Ser Asp  Gly Arg Trp 
    1835                 1840                 1845             


His Asp  Leu Arg Leu Glu Leu  Gln Glu Glu Pro Gly  Gly Arg Arg 
    1850                 1855                 1860             


Gly His  His Val Leu Met Val  Ser Leu Asp Phe Ser  Leu Phe Gln 
    1865                 1870                 1875             


Asp Xaa  Met Ala Val Gly Ser  Glu Leu Gln Gly Leu  Lys Val Lys 
    1880                 1885                 1890             


Gln Leu  His Val Gly Gly Leu  Pro Pro Gly Ser Ala  Glu Glu Ala 
    1895                 1900                 1905             


Pro Gln  Gly Leu Val Gly Cys  Ile Gln Gly Val Trp  Leu Gly Ser 
    1910                 1915                 1920             


Xaa Pro  Ser Gly Ser Pro Ala  Leu Leu Pro Pro Ser  His Arg Val 
    1925                 1930                 1935             


Asn Ala  Glu Pro Gly Cys Val  Val Xaa Asn Ala Cys  Ala Ser Gly 
    1940                 1945                 1950             


Pro Cys  Pro Pro His Ala Asp  Cys Arg Asp Leu Trp  Gln Xaa Phe 
    1955                 1960                 1965             


Ser Cys  Xaa Cys Gln Pro Gly  Tyr Tyr Gly Pro Gly  Cys Val Asp 
    1970                 1975                 1980             


Ala Cys  Leu Leu Asn Pro Cys  Gln Asn Gln Gly Ser  Cys Arg His 
    1985                 1990                 1995             


Leu Pro  Gly Ala Pro His Gly  Tyr Xaa Cys Asp Cys  Val Gly Gly 
    2000                 2005                 2010             


Tyr Phe  Gly His His Cys Glu  His Arg Met Asp Gln  Gln Cys Pro 
    2015                 2020                 2025             


Arg Gly  Trp Trp Gly Ser Pro  Xaa Cys Gly Pro Cys  Asn Cys Asp 
    2030                 2035                 2040             


Val His  Lys Gly Phe Asp Pro  Asn Cys Asn Lys Xaa  Asn Gly Gln 
    2045                 2050                 2055             


Cys His  Cys Lys Glu Phe His  Tyr Arg Pro Arg Gly  Ser Asp Ser 
    2060                 2065                 2070             


Cys Leu  Pro Cys Asp Cys Tyr  Pro Val Gly Ser Xaa  Ser Arg Ser 
    2075                 2080                 2085             


Cys Ala  Pro His Ser Gly Gln  Cys Pro Cys Arg Pro  Gly Ala Leu 
    2090                 2095                 2100             


Gly Arg  Gln Cys Asn Ser Cys  Asp Ser Pro Phe Ala  Glu Val Xaa 
    2105                 2110                 2115             


Ala Ser  Gly Cys Arg Val Leu  Tyr Asp Ala Cys Pro  Lys Ser Leu 
    2120                 2125                 2130             


Arg Ser  Gly Val Trp Trp Pro  Gln Xaa Lys Phe Gly  Val Leu Ala 
    2135                 2140                 2145             


Xaa Val  Pro Cys Pro Arg Gly  Ala Leu Gly Ala Ala  Val Arg Leu 
    2150                 2155                 2160             


Cys Asp  Glu Ala Gln Gly Trp  Leu Glu Pro Asp Leu  Phe Asn Cys 
    2165                 2170                 2175             


Xaa Ser  Pro Ala Phe Arg Glu  Leu Ser Leu Leu Leu  Asp Gly Leu 
    2180                 2185                 2190             


Glu Leu  Asn Lys Xaa Ala Leu  Asp Xaa Met Glu Ala  Lys Lys Leu 
    2195                 2200                 2205             


Ala Gln  Arg Leu Arg Glu Val  Xaa Gly His Xaa Asp  His Tyr Phe 
    2210                 2215                 2220             


Ser Gln  Asp Val Arg Val Xaa  Ala Arg Leu Leu Ala  His Leu Leu 
    2225                 2230                 2235             


Ala Phe  Glu Ser His Gln Gln  Gly Phe Gly Leu Xaa  Ala Xaa Gln 
    2240                 2245                 2250             


Asp Ala  His Phe Asn Glu Asn  Leu Leu Trp Ala Gly  Ser Ala Leu 
    2255                 2260                 2265             


Leu Ala  Pro Glu Xaa Gly Asp  Leu Trp Ala Ala Leu  Gly Gln Arg 
    2270                 2275                 2280             


Ala Pro  Gly Gly Ser Pro Gly  Ser Ala Gly Leu Val  Arg His Leu 
    2285                 2290                 2295             


Glu Glu  Tyr Ala Ala Xaa Leu  Ala Arg Asn Met Glu  Leu Xaa Tyr 
    2300                 2305                 2310             


Leu Asn  Pro Met Gly Leu Val  Xaa Pro Asn Ile Met  Leu Ser Ile 
    2315                 2320                 2325             


Asp Arg  Met Glu His Pro Ser  Ser Pro Arg Gly Ala  Arg Arg Tyr 
    2330                 2335                 2340             


Pro Arg  Tyr His Ser Asn Leu  Phe Arg Gly Gln Asp  Ala Trp Asp 
    2345                 2350                 2355             


Pro His  Xaa His Val Leu Leu  Pro Ser Gln Ser Pro  Arg Pro Ser 
    2360                 2365                 2370             


Pro Ser  Glu Val Leu Pro Xaa  Ser Ser Ser Ile Glu  Asn Ser Xaa 
    2375                 2380                 2385             


Xaa Ser  Ser Val Val Pro Pro  Pro Ala Pro Pro Glu  Pro Glu Pro 
    2390                 2395                 2400             


Gly Ile  Ser Ile Ile Ile Leu  Leu Val Tyr Arg Xaa  Leu Gly Gly 
    2405                 2410                 2415             


Leu Leu  Pro Ala Gln Phe Gln  Ala Glu Arg Arg Gly  Ala Arg Leu 
    2420                 2425                 2430             


Pro Gln  Asn Pro Val Met Asn  Ser Pro Val Val Ser  Val Ala Val 
    2435                 2440                 2445             


Phe His  Gly Arg Asn Phe Leu  Arg Gly Ile Leu Glu  Ser Pro Ile 
    2450                 2455                 2460             


Ser Leu  Glu Phe Arg Leu Leu  Gln Xaa Ala Asn Arg  Ser Lys Ala 
    2465                 2470                 2475             


Ile Cys  Val Gln Trp Asp Pro  Pro Gly Leu Ala Glu  Gln His Gly 
    2480                 2485                 2490             


Val Trp  Xaa Ala Arg Asp Cys  Glu Leu Val His Arg  Asn Gly Ser 
    2495                 2500                 2505             


His Ala  Arg Cys Arg Cys Ser  Arg Xaa Gly Xaa Phe  Gly Val Leu 
    2510                 2515                 2520             


Met Asp  Ala Ser Pro Arg Glu  Arg Leu Glu Gly Asp  Leu Glu Leu 
    2525                 2530                 2535             


Leu Ala  Val Phe Xaa His Val  Val Val Ala Val Ser  Val Ala Ala 
    2540                 2545                 2550             


Leu Val  Leu Xaa Ala Ala Ile  Leu Leu Ser Leu Arg  Ser Leu Lys 
    2555                 2560                 2565             


Ser Asn  Val Arg Gly Ile His  Ala Asn Val Ala Ala  Ala Leu Gly 
    2570                 2575                 2580             


Val Ala  Glu Leu Leu Phe Leu  Leu Gly Ile His Arg  Xaa His Asn 
    2585                 2590                 2595             


Gln Leu  Val Cys Xaa Ala Val  Ala Ile Leu Leu His  Tyr Phe Phe 
    2600                 2605                 2610             


Leu Ser  Xaa Phe Ala Trp Leu  Phe Val Gln Gly Leu  His Leu Tyr 
    2615                 2620                 2625             


Arg Met  Gln Val Glu Pro Arg  Asn Val Asp Arg Gly  Ala Met Arg 
    2630                 2635                 2640             


Phe Tyr  His Ala Leu Gly Trp  Gly Val Pro Ala Val  Leu Leu Gly 
    2645                 2650                 2655             


Leu Ala  Val Gly Leu Asp Pro  Glu Gly Tyr Gly Asn  Pro Asp Phe 
    2660                 2665                 2670             


Cys Trp  Ile Ser Val His Glu  Pro Leu Ile Trp Ser  Phe Ala Gly 
    2675                 2680                 2685             


Pro Val  Val Leu Val Ile Val  Met Asn Gly Xaa Met  Phe Leu Leu 
    2690                 2695                 2700             


Ala Ala  Arg Xaa Ser Cys Ser  Xaa Gly Gln Arg Glu  Ala Lys Lys 
    2705                 2710                 2715             


Xaa Ser  Ala Leu Xaa Leu Arg  Ser Ser Phe Leu Leu  Leu Leu Leu 
    2720                 2725                 2730             


Val Ser  Ala Ser Trp Leu Phe  Gly Leu Leu Ala Val  Asn His Ser 
    2735                 2740                 2745             


Ile Leu  Ala Phe His Tyr Leu  His Ala Gly Leu Cys  Gly Leu Gln 
    2750                 2755                 2760             


Gly Leu  Ala Val Leu Leu Leu  Phe Cys Val Leu Asn  Ala Asp Ala 
    2765                 2770                 2775             


Arg Ala  Ala Trp Met Pro Ala  Cys Leu Gly Arg Lys  Ala Ala Pro 
    2780                 2785                 2790             


Glu Glu  Ala Arg Pro Ala Pro  Gly Leu Gly Pro Gly  Ala Tyr Asn 
    2795                 2800                 2805             


Asn Xaa  Ala Leu Phe Glu Glu  Ser Gly Leu Ile Arg  Ile Xaa Leu 
    2810                 2815                 2820             


Gly Ala  Ser Xaa Val Ser Ser  Val Ser Ser Ala Arg  Ser Gly Arg 
    2825                 2830                 2835             


Xaa Gln  Asp Gln Asp Ser Gln  Arg Gly Arg Ser Tyr  Leu Arg Asp 
    2840                 2845                 2850             


Asn Val  Leu Val Arg His Gly  Ser Ala Ala Asp His  Xaa Asp His 
    2855                 2860                 2865             


Ser Leu  Gln Ala His Ala Gly  Pro Xaa Asp Leu Asp  Val Ala Met 
    2870                 2875                 2880             


Phe His  Arg Asp Ala Gly Ala  Asp Ser Asp Ser Asp  Ser Asp Leu 
    2885                 2890                 2895             


Ser Leu  Glu Glu Glu Arg Ser  Leu Ser Ile Pro Ser  Ser Glu Ser 
    2900                 2905                 2910             


Glu Asp  Asn Gly Arg Xaa Arg  Gly Arg Phe Gln Arg  Pro Leu Cys 
    2915                 2920                 2925             


Arg Ala  Ala Gln Ser Glu Arg  Leu Leu Xaa His Pro  Lys Asp Val 
    2930                 2935                 2940             


Asp Gly  Asn Asp Leu Leu Ser  Tyr Trp Pro Ala Leu  Gly Glu Cys 
    2945                 2950                 2955             


Glu Ala  Ala Pro Cys Ala Leu  Gln Xaa Trp Gly Ser  Glu Arg Arg 
    2960                 2965                 2970             


Leu Gly  Leu Asp Xaa Ser Lys  Asp Ala Ala Asn Asn  Asn Gln Pro 
    2975                 2980                 2985             


Asp Pro  Ala Leu Xaa Ser Gly  Asp Glu Xaa Ser Leu  Gly Arg Ala 
    2990                 2995                 3000             


Gln Arg  Gln Arg Lys Gly Ile  Leu Lys Asn Arg Leu  Gln Tyr Pro 
    3005                 3010                 3015             


Leu Val  Pro Gln Xaa Arg Gly  Ala Pro Glu Leu Ser  Trp Cys Arg 
    3020                 3025                 3030             


Ala Ala  Xaa Leu Gly His Arg  Ala Val Pro Ala Ala  Ser Tyr Gly 
    3035                 3040                 3045             


Arg Ile  Tyr Ala Gly Gly Gly  Xaa Gly Ser Leu Ser  Gln Pro Ala 
    3050                 3055                 3060             


Ser Arg  Tyr Ser Ser Arg Glu  Gln Leu Asp Leu Leu  Leu Arg Arg 
    3065                 3070                 3075             


Gln Leu  Ser Arg Glu Arg Leu  Glu Glu Ala Pro Ala  Pro Val Leu 
    3080                 3085                 3090             


Arg Pro  Leu Ser Arg Pro Gly  Ser Gln Glu Cys Met  Asp Ala Ala 
    3095                 3100                 3105             


Pro Gly  Arg Leu Glu Pro Lys  Asp Arg Gly Ser Xaa  Leu Pro Arg 
    3110                 3115                 3120             


Arg Gln  Pro Pro Arg Asp Tyr  Pro Gly Ala Met Ala  Gly Arg Phe 
    3125                 3130                 3135             


Gly Ser  Arg Asp Ala Leu Asp  Leu Gly Ala Pro Arg  Glu Trp Leu 
    3140                 3145                 3150             


Ser Xaa  Leu Pro Pro Pro Arg  Arg Xaa Arg Asp Leu  Asp Pro Gln 
    3155                 3160                 3165             


Pro Pro  Pro Leu Pro Leu Ser  Pro Gln Arg Gln Leu  Ser Arg Asp 
    3170                 3175                 3180             


Pro Leu  Leu Pro Ser Arg Pro  Leu Asp Ser Leu Ser  Arg Ser Ser 
    3185                 3190                 3195             


Asn Ser  Arg Glu Gln Leu Asp  Gln Val Pro Ser Arg  His Pro Ser 
    3200                 3205                 3210             


Arg Glu  Ala Leu Gly Pro Leu  Pro Gln Leu Leu Arg  Ala Arg Glu 
    3215                 3220                 3225             


Asp Ser  Val Ser Gly Pro Ser  His Gly Pro Ser Xaa  Glu Gln Leu 
    3230                 3235                 3240             


Asp Ile  Leu Ser Ser Ile Leu  Ala Ser Phe Asn Ser  Ser Ala Leu 
    3245                 3250                 3255             


Ser Ser  Val Gln Ser Ser Ser  Xaa Pro Leu Gly Pro  His Xaa Xaa 
    3260                 3265                 3270             


Ala Xaa  Pro Ser Ala Xaa Ala  Ser Val Leu Gly Pro  Ser Xaa Pro 
    3275                 3280                 3285             


Arg Ser  Ala Xaa Ser His Ser  Ile Ser Glu Leu Ser  Pro Asp Ser 
    3290                 3295                 3300             


Glu Val  Pro Arg Ser Glu Gly  His Ser 
    3305                 3310         


<210> 5847
<211> 1086
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<400> 5847
Met Phe Leu Met Pro Xaa Ser Ser Glu Leu Asn Ser Gly Gln Asn Phe 
1               5                   10                  15      


Leu Xaa Gln Trp Met Xaa Asn Pro Ser Arg Ala Gly Val Ile Leu Asn 
            20                  25                  30          


Arg Gly Phe Pro Ile Leu Glu Ala Asp Lys Glu Lys Arg Ala Ala Val 
        35                  40                  45              


Asp Ile Ser Xaa Ser Phe Pro Ile Lys Gly Xaa His Phe Ser Asp Ser 
    50                  55                  60                  


Phe Ser Phe Ile Asn Glu Glu Asp Ser Leu Leu Glu Glu Gln Lys Leu 
65                  70                  75                  80  


Glu Ser Asn Asn Pro Tyr Lys Pro Gln Ser Asp Lys Ser Glu Xaa His 
                85                  90                  95      


Xaa Ala Phe Pro Cys Ile Lys Lys Gly Pro Gln Val Ala Ala Cys His 
            100                 105                 110         


Ser Ala Pro Gly His Gln Glu Glu Asn Lys Asn Asp Phe Ile Pro Asp 
        115                 120                 125             


Leu Ala Ser Glu Phe Lys Glu Gly Ala Tyr Lys Asp Pro Leu Phe Lys 
    130                 135                 140                 


Lys Leu Glu Gln Leu Lys Glu Val Gln Gln Lys Lys Gln Glu Gln Leu 
145                 150                 155                 160 


Lys Arg Gln Gln Leu Glu Gln Leu Gln Arg Leu Met Glu Glu Gln Glu 
                165                 170                 175     


Lys Leu Leu Xaa Met Val Ser Gly Gln Cys Xaa Leu Pro Gly Leu Ser 
            180                 185                 190         


Leu Leu Pro Asp Asp Gln Ser Gln Lys His Arg Ser Pro Gly Asn Xaa 
        195                 200                 205             


Xaa Xaa Gly Glu Arg Ala Xaa Cys Cys Phe Pro Ser Tyr Val Tyr Pro 
    210                 215                 220                 


Asp Pro Xaa Gln Glu Glu Xaa Tyr Pro Ser Asn Ile Leu Ser His Glu 
225                 230                 235                 240 


Gln Ser Asn Phe Cys Arg Xaa Ala His Gly Asp Phe Val Leu Xaa Ser 
                245                 250                 255     


Lys Arg Ala Ser Pro Asn Leu Phe Ser Glu Ala Gln Tyr Gln Glu Ala 
            260                 265                 270         


Pro Val Glu Lys Asn Asn Leu Lys Glu Glu Asn Arg Asn His Pro Xaa 
        275                 280                 285             


Gly Glu Ser Ile Leu Cys Trp Glu Lys Val Xaa Glu Gln Ile Gln Glu 
    290                 295                 300                 


Ala Asn Asp Lys Asn Leu Gln Lys His Asp Asp Ser Ser Glu Val Ala 
305                 310                 315                 320 


Asn Ile Glu Glu Arg Pro Ile Lys Ala Ala Ile Gly Glu Arg Lys Gln 
                325                 330                 335     


Xaa Phe Glu Asp Tyr Leu Glu Glu Gln Ile Gln Leu Glu Glu Gln Glu 
            340                 345                 350         


Leu Lys Gln Lys Gln Leu Lys Glu Ala Glu Gly Pro Leu Pro Ile Lys 
        355                 360                 365             


Ala Lys Pro Lys Gln Pro Phe Leu Lys Arg Gly Glu Gly Leu Ala Arg 
    370                 375                 380                 


Phe Xaa Asn Ala Lys Ser Lys Phe Gln Lys Gly Lys Glu Ser Lys Leu 
385                 390                 395                 400 


Val Xaa Asn Gln Ser Xaa Ser Glu Asp Gln Pro Leu Phe Lys Met Asp 
                405                 410                 415     


Arg Gln Gln Leu Gln Arg Lys Xaa Ala Leu Lys Asn Lys Glu Leu Cys 
            420                 425                 430         


Ala Asp Asn Pro Ile Leu Lys Lys Asp Ser Lys Ala Arg Xaa Lys Ser 
        435                 440                 445             


Gly Ser Val Xaa Leu Ser Gln Lys Pro Lys Met Leu Lys Cys Ser Asn 
    450                 455                 460                 


Arg Lys Ser Leu Ser Pro Ser Gly Leu Lys Ile Gln Xaa Gly Lys Lys 
465                 470                 475                 480 


Cys Asp Gly Gln Phe Arg Asp Gln Ile Lys Phe Glu Asn Lys Val Xaa 
                485                 490                 495     


Ser Asn Asn Lys Glu Asn Val Xaa Glu Cys Pro Lys Pro Cys Asp Xaa 
            500                 505                 510         


Gly Cys Xaa Gly Trp Asn Lys Xaa Gln Gly Lys Asp Arg Leu Pro Leu 
        515                 520                 525             


Ser Xaa Gly Pro Ala Ser Arg Leu Ala Ala Lys Ser Pro Ile Arg Glu 
    530                 535                 540                 


Xaa Met Lys Glu Ser Glu Ser Ser Leu Asp Val Ser Leu Gln Lys Lys 
545                 550                 555                 560 


Leu Glu Xaa Trp Glu Arg Glu Lys Glu Lys Glu Asn Leu Glu Leu Asp 
                565                 570                 575     


Glu Phe Leu Phe Leu Glu Gln Ala Ala Asp Glu Ile Ser Phe Ser Ser 
            580                 585                 590         


Asn Ser Ser Phe Val Leu Lys Ile Leu Glu Arg Asp Gln Gln Ile Cys 
        595                 600                 605             


Lys Gly His Arg Met Ser Ser Xaa Pro Val Lys Ala Val Pro Gln Lys 
    610                 615                 620                 


Xaa Asn Pro Ala Asp Pro Ile Ser His Cys Asn Arg Ser Glu Asp Leu 
625                 630                 635                 640 


Asp His Xaa Ala Arg Glu Lys Glu Ser Glu Cys Glu Val Ala Pro Lys 
                645                 650                 655     


Gln Leu His Ser Leu Ser Ser Ala Asp Glu Leu Arg Glu Gln Pro Cys 
            660                 665                 670         


Lys Ile Arg Lys Ala Val Gln Lys Ser Xaa Ser Glu Asn Gln Xaa Glu 
        675                 680                 685             


Trp Asn Ala Arg Asp Asp Glu Gly Val Pro Asn Ser Asp Ser Ser Xaa 
    690                 695                 700                 


Asp Ser Glu Glu Gln Leu Asp Val Xaa Ile Lys Pro Ser Xaa Glu Asp 
705                 710                 715                 720 


Arg Glu Arg Gly Ile Ser Ser Arg Glu Asp Ser Pro Gln Val Cys Asp 
                725                 730                 735     


Asp Lys Gly Pro Phe Lys Asp Xaa Arg Xaa Gln Glu Asp Lys Arg Arg 
            740                 745                 750         


Asp Val Asp Leu Asp Leu Ser Asp Lys Asp Tyr Ser Ser Asp Glu Ser 
        755                 760                 765             


Ile Met Glu Ser Ile Lys His Lys Val Ser Glu Pro Ser Arg Ser Ser 
    770                 775                 780                 


Ser Leu Ser Leu Ser Lys Met Asp Phe Asp Asp Glu Arg Xaa Trp Xaa 
785                 790                 795                 800 


Asp Leu Glu Glu Asn Leu Cys Asn His Asp Val Val Leu Gly Asn Glu 
                805                 810                 815     


Ser Xaa Tyr Gly Xaa Pro Gln Xaa Cys Tyr Pro Asn Asn Glu Ile Gly 
            820                 825                 830         


Ile Leu Asp Lys Xaa Ile Lys Arg Lys Ile Ala Pro Val Lys Arg Gly 
        835                 840                 845             


Glu Asp Leu Ser Lys Ser Arg Arg Ser Arg Ser Pro Pro Xaa Ser Glu 
    850                 855                 860                 


Leu Met Met Lys Phe Phe Pro Ser Leu Lys Pro Lys Pro Lys Ser Asp 
865                 870                 875                 880 


Ser His Leu Gly Asn Glu Leu Lys Leu Asn Ile Ser Gln Asp Gln Pro 
                885                 890                 895     


Pro Gly Asp Asn Ala Arg Ser Gln Val Leu Arg Glu Lys Ile Ile Glu 
            900                 905                 910         


Leu Glu Xaa Glu Ile Glu Lys Phe Lys Ala Glu Asn Ala Ser Leu Ala 
        915                 920                 925             


Lys Leu Arg Ile Glu Arg Glu Ser Ala Leu Glu Lys Leu Arg Lys Glu 
    930                 935                 940                 


Ile Ala Asp Phe Glu Gln Gln Lys Ala Lys Glu Leu Ala Arg Ile Glu 
945                 950                 955                 960 


Glu Phe Lys Lys Glu Glu Met Arg Lys Leu Gln Lys Glu Arg Lys Val 
                965                 970                 975     


Phe Glu Lys Tyr Xaa Xaa Ala Ala Arg Xaa Phe Pro Asp Lys Lys Glu 
            980                 985                 990         


Arg Glu Glu Ile Gln Xaa Leu Lys  Gln Gln Ile Ala Asp  Leu Arg Glu 
        995                 1000                 1005             


Asp Leu  Lys Arg Lys Glu Xaa  Lys Trp Ser Ser Xaa  His Ser Arg 
    1010                 1015                 1020             


Leu Arg  Ser Gln Ile Gln Met  Leu Val Arg Glu Asn  Xaa Asp Leu 
    1025                 1030                 1035             


Arg Glu  Glu Ile Lys Val Met  Glu Arg Phe Arg Leu  Asp Ala Trp 
    1040                 1045                 1050             


Lys Arg  Ala Glu Ala Ile Glu  Ser Ser Leu Glu Val  Glu Lys Lys 
    1055                 1060                 1065             


Asp Lys  Leu Ala Ala Ile His  Leu Glu Asp Pro Ser  Leu His Leu 
    1070                 1075                 1080             


Leu Val  Ile 
    1085     


<210> 5848
<211> 1136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1108)..(1108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<400> 5848
Met Phe Leu Met Pro Xaa Ser Ser Glu Leu Asn Ser Gly Gln Asn Phe 
1               5                   10                  15      


Leu Xaa Gln Trp Met Xaa Asn Pro Ser Arg Ala Gly Val Ile Leu Asn 
            20                  25                  30          


Arg Gly Phe Pro Ile Leu Glu Ala Asp Lys Glu Lys Arg Ala Ala Val 
        35                  40                  45              


Asp Ile Ser Xaa Ser Phe Pro Ile Lys Gly Xaa His Phe Ser Asp Ser 
    50                  55                  60                  


Phe Ser Phe Ile Asn Glu Glu Asp Ser Leu Leu Glu Glu Gln Lys Leu 
65                  70                  75                  80  


Glu Ser Asn Asn Pro Tyr Lys Pro Gln Ser Asp Lys Ser Glu Xaa His 
                85                  90                  95      


Xaa Ala Phe Pro Cys Ile Lys Lys Gly Pro Gln Val Ala Ala Cys His 
            100                 105                 110         


Ser Ala Pro Gly His Gln Glu Glu Asn Lys Asn Asp Phe Ile Pro Asp 
        115                 120                 125             


Leu Ala Ser Glu Phe Lys Glu Gly Ala Tyr Lys Asp Pro Leu Phe Lys 
    130                 135                 140                 


Lys Leu Glu Gln Leu Lys Glu Val Gln Gln Lys Lys Gln Glu Gln Leu 
145                 150                 155                 160 


Lys Arg Gln Gln Leu Glu Gln Leu Gln Arg Leu Met Glu Glu Gln Glu 
                165                 170                 175     


Lys Leu Leu Xaa Met Val Ser Gly Gln Cys Xaa Leu Pro Gly Leu Ser 
            180                 185                 190         


Leu Leu Pro Asp Asp Gln Ser Gln Lys His Arg Ser Pro Gly Asn Xaa 
        195                 200                 205             


Xaa Xaa Gly Glu Arg Ala Xaa Cys Cys Phe Pro Ser Tyr Val Tyr Pro 
    210                 215                 220                 


Asp Pro Xaa Gln Glu Glu Xaa Tyr Pro Ser Asn Ile Leu Ser His Glu 
225                 230                 235                 240 


Gln Ser Asn Phe Cys Arg Xaa Ala His Gly Asp Phe Val Leu Xaa Ser 
                245                 250                 255     


Lys Arg Ala Ser Pro Asn Leu Phe Ser Glu Ala Gln Tyr Gln Glu Ala 
            260                 265                 270         


Pro Val Glu Lys Asn Asn Leu Lys Glu Glu Asn Arg Asn His Pro Xaa 
        275                 280                 285             


Gly Glu Ser Ile Leu Cys Trp Glu Lys Val Xaa Glu Gln Ile Gln Glu 
    290                 295                 300                 


Ala Asn Asp Lys Asn Leu Gln Lys His Asp Asp Ser Ser Glu Val Ala 
305                 310                 315                 320 


Asn Ile Glu Glu Arg Pro Ile Lys Ala Ala Ile Gly Glu Arg Lys Gln 
                325                 330                 335     


Xaa Phe Glu Asp Tyr Leu Glu Glu Gln Ile Gln Leu Glu Glu Gln Glu 
            340                 345                 350         


Leu Lys Gln Lys Gln Leu Lys Glu Ala Glu Gly Pro Leu Pro Ile Lys 
        355                 360                 365             


Ala Lys Pro Lys Gln Pro Phe Leu Lys Arg Gly Glu Gly Leu Ala Arg 
    370                 375                 380                 


Phe Xaa Asn Ala Lys Ser Lys Phe Gln Lys Gly Lys Glu Ser Lys Leu 
385                 390                 395                 400 


Val Xaa Asn Gln Ser Xaa Ser Glu Asp Gln Pro Leu Phe Lys Met Asp 
                405                 410                 415     


Arg Gln Gln Leu Gln Arg Lys Xaa Ala Leu Lys Asn Lys Glu Leu Cys 
            420                 425                 430         


Ala Asp Asn Pro Ile Leu Lys Lys Asp Ser Lys Ala Arg Xaa Lys Ser 
        435                 440                 445             


Gly Ser Val Xaa Leu Ser Gln Lys Pro Lys Met Leu Lys Cys Ser Asn 
    450                 455                 460                 


Arg Lys Ser Leu Ser Pro Ser Gly Leu Lys Ile Gln Xaa Gly Lys Lys 
465                 470                 475                 480 


Cys Asp Gly Gln Phe Arg Asp Gln Ile Lys Phe Glu Asn Lys Val Xaa 
                485                 490                 495     


Ser Asn Asn Lys Glu Asn Val Xaa Glu Cys Pro Lys Pro Cys Asp Xaa 
            500                 505                 510         


Gly Cys Xaa Gly Trp Asn Lys Xaa Gln Gly Lys Asp Arg Leu Pro Leu 
        515                 520                 525             


Ser Xaa Gly Pro Ala Ser Arg Leu Ala Ala Lys Ser Pro Ile Arg Glu 
    530                 535                 540                 


Xaa Met Lys Glu Ser Glu Ser Ser Leu Asp Val Ser Leu Gln Lys Lys 
545                 550                 555                 560 


Leu Glu Xaa Trp Glu Arg Glu Lys Glu Lys Glu Asn Leu Glu Leu Asp 
                565                 570                 575     


Glu Phe Leu Phe Leu Glu Gln Ala Ala Asp Glu Ile Ser Phe Ser Ser 
            580                 585                 590         


Asn Ser Ser Phe Val Leu Lys Ile Leu Glu Arg Asp Gln Gln Ile Cys 
        595                 600                 605             


Lys Gly His Arg Met Ser Ser Xaa Pro Val Lys Ala Val Pro Gln Lys 
    610                 615                 620                 


Xaa Asn Pro Ala Asp Pro Ile Ser His Cys Asn Arg Ser Glu Asp Leu 
625                 630                 635                 640 


Asp His Xaa Ala Arg Glu Lys Glu Ser Glu Cys Glu Val Ala Pro Lys 
                645                 650                 655     


Gln Leu His Ser Leu Ser Ser Ala Asp Glu Leu Arg Glu Gln Pro Cys 
            660                 665                 670         


Lys Ile Arg Lys Ala Val Gln Lys Ser Xaa Ser Glu Asn Gln Xaa Glu 
        675                 680                 685             


Trp Asn Ala Arg Asp Asp Glu Gly Val Pro Asn Ser Asp Ser Ser Xaa 
    690                 695                 700                 


Asp Ser Glu Glu Gln Leu Asp Val Xaa Ile Lys Pro Ser Xaa Glu Asp 
705                 710                 715                 720 


Arg Glu Arg Gly Ile Ser Ser Arg Glu Asp Ser Pro Gln Val Cys Asp 
                725                 730                 735     


Asp Lys Gly Pro Phe Lys Asp Xaa Arg Xaa Gln Glu Asp Lys Arg Arg 
            740                 745                 750         


Asp Val Asp Leu Asp Leu Ser Asp Lys Asp Tyr Ser Ser Asp Glu Ser 
        755                 760                 765             


Ile Met Glu Ser Ile Lys His Lys Val Ser Glu Pro Ser Arg Ser Ser 
    770                 775                 780                 


Ser Leu Ser Leu Ser Lys Met Asp Phe Asp Asp Glu Arg Xaa Trp Xaa 
785                 790                 795                 800 


Asp Leu Glu Glu Asn Leu Cys Asn His Asp Val Val Leu Gly Asn Glu 
                805                 810                 815     


Ser Xaa Tyr Gly Xaa Pro Gln Xaa Cys Tyr Pro Asn Asn Glu Ile Gly 
            820                 825                 830         


Ile Leu Asp Lys Xaa Ile Lys Arg Lys Ile Ala Pro Val Lys Arg Gly 
        835                 840                 845             


Glu Asp Leu Ser Lys Ser Arg Arg Ser Arg Ser Pro Pro Xaa Ser Glu 
    850                 855                 860                 


Leu Met Met Lys Phe Phe Pro Ser Leu Lys Pro Lys Pro Lys Ser Asp 
865                 870                 875                 880 


Ser His Leu Gly Asn Glu Leu Lys Leu Asn Ile Ser Gln Asp Gln Pro 
                885                 890                 895     


Pro Gly Asp Asn Ala Arg Ser Gln Val Leu Arg Glu Lys Ile Ile Glu 
            900                 905                 910         


Leu Glu Xaa Glu Ile Glu Lys Phe Lys Ala Glu Asn Ala Ser Leu Ala 
        915                 920                 925             


Lys Leu Arg Ile Glu Arg Glu Ser Ala Leu Glu Lys Leu Arg Lys Glu 
    930                 935                 940                 


Ile Ala Asp Phe Glu Gln Gln Lys Ala Lys Glu Leu Ala Arg Ile Glu 
945                 950                 955                 960 


Glu Phe Lys Lys Glu Glu Met Arg Lys Leu Gln Lys Glu Arg Lys Val 
                965                 970                 975     


Phe Glu Lys Tyr Xaa Xaa Ala Ala Arg Xaa Phe Pro Asp Lys Lys Glu 
            980                 985                 990         


Arg Glu Glu Ile Gln Xaa Leu Lys  Gln Gln Ile Ala Asp  Leu Arg Glu 
        995                 1000                 1005             


Asp Leu  Lys Arg Lys Glu Xaa  Lys Trp Ser Ser Xaa  His Ser Arg 
    1010                 1015                 1020             


Leu Arg  Ser Gln Ile Gln Met  Leu Val Arg Glu Asn  Xaa Asp Leu 
    1025                 1030                 1035             


Arg Glu  Glu Ile Lys Val Met  Glu Arg Phe Arg Leu  Asp Ala Trp 
    1040                 1045                 1050             


Lys Arg  Ala Glu Ala Ile Glu  Ser Ser Leu Glu Val  Glu Lys Lys 
    1055                 1060                 1065             


Asp Lys  Leu Ala Asn Xaa Ser  Val Arg Phe Gln Asn  Ser Gln Ile 
    1070                 1075                 1080             


Ser Ser  Gly Xaa Gln Val Glu  Lys Tyr Lys Lys Asn  Tyr Leu Pro 
    1085                 1090                 1095             


Met Gln  Gly Xaa Ala Gln Pro  Pro His Xaa Pro Ser  Ser Leu Leu 
    1100                 1105                 1110             


Ala Asp  His Leu Pro Pro Leu  Ser Ser Phe Arg Pro  Phe Ser Arg 
    1115                 1120                 1125             


Asn Ile  Gln Leu Cys Tyr Xaa  Phe 
    1130                 1135     


<210> 5849
<211> 1338
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1187)..(1187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1189)..(1189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1191)..(1191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1218)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1246)..(1246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1304)..(1304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1316)..(1316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<400> 5849
Met Phe Leu Met Pro Xaa Ser Ser Glu Leu Asn Ser Gly Gln Asn Phe 
1               5                   10                  15      


Leu Xaa Gln Trp Met Xaa Asn Pro Ser Arg Ala Gly Val Ile Leu Asn 
            20                  25                  30          


Arg Gly Phe Pro Ile Leu Glu Ala Asp Lys Glu Lys Arg Ala Ala Val 
        35                  40                  45              


Asp Ile Ser Xaa Ser Phe Pro Ile Lys Gly Xaa His Phe Ser Asp Ser 
    50                  55                  60                  


Phe Ser Phe Ile Asn Glu Glu Asp Ser Leu Leu Glu Glu Gln Lys Leu 
65                  70                  75                  80  


Glu Ser Asn Asn Pro Tyr Lys Pro Gln Ser Asp Lys Ser Glu Xaa His 
                85                  90                  95      


Xaa Ala Phe Pro Cys Ile Lys Lys Gly Pro Gln Val Ala Ala Cys His 
            100                 105                 110         


Ser Ala Pro Gly His Gln Glu Glu Asn Lys Asn Asp Phe Ile Pro Asp 
        115                 120                 125             


Leu Ala Ser Glu Phe Lys Glu Gly Ala Tyr Lys Asp Pro Leu Phe Lys 
    130                 135                 140                 


Lys Leu Glu Gln Leu Lys Glu Val Gln Gln Lys Lys Gln Glu Gln Leu 
145                 150                 155                 160 


Lys Arg Gln Gln Leu Glu Gln Leu Gln Arg Leu Met Glu Glu Gln Glu 
                165                 170                 175     


Lys Leu Leu Xaa Met Val Ser Gly Gln Cys Xaa Leu Pro Gly Leu Ser 
            180                 185                 190         


Leu Leu Pro Asp Asp Gln Ser Gln Lys His Arg Ser Pro Gly Asn Xaa 
        195                 200                 205             


Xaa Xaa Gly Glu Arg Ala Xaa Cys Cys Phe Pro Ser Tyr Val Tyr Pro 
    210                 215                 220                 


Asp Pro Xaa Gln Glu Glu Xaa Tyr Pro Ser Asn Ile Leu Ser His Glu 
225                 230                 235                 240 


Gln Ser Asn Phe Cys Arg Xaa Ala His Gly Asp Phe Val Leu Xaa Ser 
                245                 250                 255     


Lys Arg Ala Ser Pro Asn Leu Phe Ser Glu Ala Gln Tyr Gln Glu Ala 
            260                 265                 270         


Pro Val Glu Lys Asn Asn Leu Lys Glu Glu Asn Arg Asn His Pro Xaa 
        275                 280                 285             


Gly Glu Ser Ile Leu Cys Trp Glu Lys Val Xaa Glu Gln Ile Gln Glu 
    290                 295                 300                 


Ala Asn Asp Lys Asn Leu Gln Lys His Asp Asp Ser Ser Glu Val Ala 
305                 310                 315                 320 


Asn Ile Glu Glu Arg Pro Ile Lys Ala Ala Ile Gly Glu Arg Lys Gln 
                325                 330                 335     


Xaa Phe Glu Asp Tyr Leu Glu Glu Gln Ile Gln Leu Glu Glu Gln Glu 
            340                 345                 350         


Leu Lys Gln Lys Gln Leu Lys Glu Ala Glu Gly Pro Leu Pro Ile Lys 
        355                 360                 365             


Ala Lys Pro Lys Gln Pro Phe Leu Lys Arg Gly Glu Gly Leu Ala Arg 
    370                 375                 380                 


Phe Xaa Asn Ala Lys Ser Lys Phe Gln Lys Gly Lys Glu Ser Lys Leu 
385                 390                 395                 400 


Val Xaa Asn Gln Ser Xaa Ser Glu Asp Gln Pro Leu Phe Lys Met Asp 
                405                 410                 415     


Arg Gln Gln Leu Gln Arg Lys Xaa Ala Leu Lys Asn Lys Glu Leu Cys 
            420                 425                 430         


Ala Asp Asn Pro Ile Leu Lys Lys Asp Ser Lys Ala Arg Xaa Lys Ser 
        435                 440                 445             


Gly Ser Val Xaa Leu Ser Gln Lys Pro Lys Met Leu Lys Cys Ser Asn 
    450                 455                 460                 


Arg Lys Ser Leu Ser Pro Ser Gly Leu Lys Ile Gln Xaa Gly Lys Lys 
465                 470                 475                 480 


Cys Asp Gly Gln Phe Arg Asp Gln Ile Lys Phe Glu Asn Lys Val Xaa 
                485                 490                 495     


Ser Asn Asn Lys Glu Asn Val Xaa Glu Cys Pro Lys Pro Cys Asp Xaa 
            500                 505                 510         


Gly Cys Xaa Gly Trp Asn Lys Xaa Gln Gly Lys Asp Arg Leu Pro Leu 
        515                 520                 525             


Ser Xaa Gly Pro Ala Ser Arg Leu Ala Ala Lys Ser Pro Ile Arg Glu 
    530                 535                 540                 


Xaa Met Lys Glu Ser Glu Ser Ser Leu Asp Val Ser Leu Gln Lys Lys 
545                 550                 555                 560 


Leu Glu Xaa Trp Glu Arg Glu Lys Glu Lys Glu Asn Leu Glu Leu Asp 
                565                 570                 575     


Glu Phe Leu Phe Leu Glu Gln Ala Ala Asp Glu Ile Ser Phe Ser Ser 
            580                 585                 590         


Asn Ser Ser Phe Val Leu Lys Ile Leu Glu Arg Asp Gln Gln Ile Cys 
        595                 600                 605             


Lys Gly His Arg Met Ser Ser Xaa Pro Val Lys Ala Val Pro Gln Lys 
    610                 615                 620                 


Xaa Asn Pro Ala Asp Pro Ile Ser His Cys Asn Arg Ser Glu Asp Leu 
625                 630                 635                 640 


Asp His Xaa Ala Arg Glu Lys Glu Ser Glu Cys Glu Val Ala Pro Lys 
                645                 650                 655     


Gln Leu His Ser Leu Ser Ser Ala Asp Glu Leu Arg Glu Gln Pro Cys 
            660                 665                 670         


Lys Ile Arg Lys Ala Val Gln Lys Ser Xaa Ser Glu Asn Gln Xaa Glu 
        675                 680                 685             


Trp Asn Ala Arg Asp Asp Glu Gly Val Pro Asn Ser Asp Ser Ser Xaa 
    690                 695                 700                 


Asp Ser Glu Glu Gln Leu Asp Val Xaa Ile Lys Pro Ser Xaa Glu Asp 
705                 710                 715                 720 


Arg Glu Arg Gly Ile Ser Ser Arg Glu Asp Ser Pro Gln Val Cys Asp 
                725                 730                 735     


Asp Lys Gly Pro Phe Lys Asp Xaa Arg Xaa Gln Glu Asp Lys Arg Arg 
            740                 745                 750         


Asp Val Asp Leu Asp Leu Ser Asp Lys Asp Tyr Ser Ser Asp Glu Ser 
        755                 760                 765             


Ile Met Glu Ser Ile Lys His Lys Val Ser Glu Pro Ser Arg Ser Ser 
    770                 775                 780                 


Ser Leu Ser Leu Ser Lys Met Asp Phe Asp Asp Glu Arg Xaa Trp Xaa 
785                 790                 795                 800 


Asp Leu Glu Glu Asn Leu Cys Asn His Asp Val Val Leu Gly Asn Glu 
                805                 810                 815     


Ser Xaa Tyr Gly Xaa Pro Gln Xaa Cys Tyr Pro Asn Asn Glu Ile Gly 
            820                 825                 830         


Ile Leu Asp Lys Xaa Ile Lys Arg Lys Ile Ala Pro Val Lys Arg Gly 
        835                 840                 845             


Glu Asp Leu Ser Lys Ser Arg Arg Ser Arg Ser Pro Pro Xaa Ser Glu 
    850                 855                 860                 


Leu Met Met Lys Phe Phe Pro Ser Leu Lys Pro Lys Pro Lys Ser Asp 
865                 870                 875                 880 


Ser His Leu Gly Asn Glu Leu Lys Leu Asn Ile Ser Gln Asp Gln Pro 
                885                 890                 895     


Pro Gly Asp Asn Ala Arg Ser Gln Val Leu Arg Glu Lys Ile Ile Glu 
            900                 905                 910         


Leu Glu Xaa Glu Ile Glu Lys Phe Lys Ala Glu Asn Ala Ser Leu Ala 
        915                 920                 925             


Lys Leu Arg Ile Glu Arg Glu Ser Ala Leu Glu Lys Leu Arg Lys Glu 
    930                 935                 940                 


Ile Ala Asp Phe Glu Gln Gln Lys Ala Lys Glu Leu Ala Arg Ile Glu 
945                 950                 955                 960 


Glu Phe Lys Lys Glu Glu Met Arg Lys Leu Gln Lys Glu Arg Lys Val 
                965                 970                 975     


Phe Glu Lys Tyr Xaa Xaa Ala Ala Arg Xaa Phe Pro Asp Lys Lys Glu 
            980                 985                 990         


Arg Glu Glu Ile Gln Xaa Leu Lys  Gln Gln Ile Ala Asp  Leu Arg Glu 
        995                 1000                 1005             


Asp Leu  Lys Arg Lys Glu Xaa  Lys Trp Ser Ser Xaa  His Ser Arg 
    1010                 1015                 1020             


Leu Arg  Ser Gln Ile Gln Met  Leu Val Arg Glu Asn  Xaa Asp Leu 
    1025                 1030                 1035             


Arg Glu  Glu Ile Lys Val Met  Glu Arg Phe Arg Leu  Asp Ala Trp 
    1040                 1045                 1050             


Lys Arg  Ala Glu Ala Ile Glu  Ser Ser Leu Glu Val  Glu Lys Lys 
    1055                 1060                 1065             


Asp Lys  Leu Ala Asn Xaa Ser  Val Arg Phe Gln Asn  Ser Gln Ile 
    1070                 1075                 1080             


Ser Ser  Gly Xaa Gln Val Glu  Lys Tyr Lys Lys Asn  Tyr Leu Pro 
    1085                 1090                 1095             


Met Gln  Gly Asn Pro Pro Arg  Arg Ser Lys Ser Ala  Pro Pro Arg 
    1100                 1105                 1110             


Asp Leu  Gly Asn Leu Asp Lys  Gly Gln Ala Ala Ser  Pro Arg Glu 
    1115                 1120                 1125             


Pro Leu  Glu Pro Leu Asn Phe  Pro Asp Pro Glu Tyr  Lys Glu Glu 
    1130                 1135                 1140             


Glu Glu  Asp Gln Asp Ile Gln  Gly Glu Ile Ser His  Pro Asp Gly 
    1145                 1150                 1155             


Lys Val  Glu Lys Val Tyr Lys  Asn Gly Cys Arg Val  Ile Leu Phe 
    1160                 1165                 1170             


Pro Asn  Gly Xaa Arg Lys Glu  Val Ser Ala Asp Gly  Lys Xaa Ile 
    1175                 1180                 1185             


Xaa Val  Xaa Phe Phe Asn Gly  Asp Val Lys Gln Val  Met Pro Asp 
    1190                 1195                 1200             


Gln Arg  Val Ile Tyr Tyr Tyr  Ala Ala Ala Gln Xaa  Xaa His Xaa 
    1205                 1210                 1215             


Xaa Tyr  Pro Glu Gly Leu Glu  Val Leu His Phe Ser  Ser Gly Gln 
    1220                 1225                 1230             


Ile Glu  Lys His Tyr Pro Asp  Gly Arg Lys Glu Ile  Xaa Phe Pro 
    1235                 1240                 1245             


Asp Gln  Xaa Val Lys Asn Leu  Phe Pro Asp Gly Gln  Glu Glu Ser 
    1250                 1255                 1260             


Ile Phe  Pro Asp Gly Xaa Ile  Val Arg Val Gln Arg  Asp Gly Asn 
    1265                 1270                 1275             


Lys Leu  Ile Glu Phe Asn Asn  Gly Gln Arg Glu Leu  His Xaa Ala 
    1280                 1285                 1290             


Gln Phe  Lys Arg Arg Glu Tyr  Pro Asp Gly Xaa Val  Lys Xaa Val 
    1295                 1300                 1305             


Tyr Ala  Asn Gly His Gln Glu  Xaa Lys Tyr Arg Ser  Gly Arg Ile 
    1310                 1315                 1320             


Arg Val  Lys Asp Lys Glu Gly  Asn Val Leu Met Asp  Xaa Glu Leu 
    1325                 1330                 1335             


<210> 5850
<211> 196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 5850
Xaa Phe Lys Ala Glu Asn Ala Ser Leu Ala Lys Leu Arg Ile Glu Arg 
1               5                   10                  15      


Glu Ser Ala Leu Glu Lys Leu Arg Lys Glu Ile Ala Asp Phe Glu Gln 
            20                  25                  30          


Gln Lys Ala Lys Glu Leu Ala Arg Ile Glu Glu Phe Lys Lys Glu Glu 
        35                  40                  45              


Met Arg Lys Leu Gln Lys Glu Arg Lys Val Phe Glu Lys Tyr Xaa Xaa 
    50                  55                  60                  


Ala Ala Arg Xaa Phe Pro Asp Lys Lys Glu Arg Glu Glu Ile Gln Xaa 
65                  70                  75                  80  


Leu Lys Gln Gln Ile Ala Asp Leu Arg Glu Asp Leu Lys Arg Lys Glu 
                85                  90                  95      


Xaa Lys Trp Ser Ser Xaa His Ser Arg Leu Arg Ser Gln Ile Gln Met 
            100                 105                 110         


Leu Val Arg Glu Asn Xaa Asp Leu Arg Glu Glu Ile Lys Val Met Glu 
        115                 120                 125             


Arg Phe Arg Leu Asp Ala Trp Lys Arg Ala Glu Ala Ile Glu Ser Ser 
    130                 135                 140                 


Leu Glu Val Glu Lys Lys Asp Lys Leu Ala Asn Xaa Ser Val Arg Phe 
145                 150                 155                 160 


Gln Asn Ser Gln Ile Ser Ser Gly Xaa Gln Val Glu Lys Tyr Lys Lys 
                165                 170                 175     


Asn Tyr Leu Pro Met Gln Gly Lys Arg Leu His Asp Leu Phe Ile Lys 
            180                 185                 190         


His Phe Arg Met 
        195     


<210> 5851
<211> 270
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<400> 5851
Met Ala Ala Ala Ser Val Ser Ala Ala Ser Gly Ser His Leu Ser Asn 
1               5                   10                  15      


Ser Phe Ala Glu Pro Ser Arg Ser Asn Gly Ser Met Val Arg His Ser 
            20                  25                  30          


Ser Ser Pro Tyr Val Val Tyr Pro Ser Asp Lys Pro Phe Leu Asn Ser 
        35                  40                  45              


Asp Leu Arg Arg Ser Pro Ser Lys Pro Xaa Leu Ala Tyr Pro Glu Ser 
    50                  55                  60                  


Asn Ser Arg Ala Ile Phe Ser Ala Leu Lys Asn Leu Gln Asp Lys Ile 
65                  70                  75                  80  


Arg Arg Leu Glu Leu Glu Arg Ile Gln Ala Glu Glu Ser Val Lys Xaa 
                85                  90                  95      


Leu Ser Arg Glu Xaa Ile Glu Tyr Lys Lys Val Leu Asp Glu Gln Ile 
            100                 105                 110         


Gln Glu Arg Glu Asn Ser Lys Asn Glu Glu Ser Lys His Asn Gln Glu 
        115                 120                 125             


Leu Xaa Ser Gln Leu Leu Ala Ala Glu Asn Lys Cys Asn Leu Leu Glu 
    130                 135                 140                 


Lys Gln Leu Glu Tyr Met Arg Asn Met Ile Lys His Ala Glu Met Glu 
145                 150                 155                 160 


Arg Xaa Ser Val Leu Glu Lys Gln Val Ser Leu Glu Arg Glu Arg Gln 
                165                 170                 175     


His Asp Gln Xaa His Val Gln Ser Gln Leu Glu Lys Leu Asp Leu Leu 
            180                 185                 190         


Glu Gln Glu Tyr Asn Lys Leu Xaa Xaa Met Gln Ala Leu Ala Glu Lys 
        195                 200                 205             


Lys Met Gln Glu Leu Glu Ala Lys Leu His Glu Glu Glu Gln Glu Arg 
    210                 215                 220                 


Lys Arg Met Gln Ala Lys Ala Ala Glu Leu Gln Xaa Gly Leu Glu Xaa 
225                 230                 235                 240 


Asn Arg Leu Ile Phe Glu Asp Lys Ala Xaa Pro Cys Val Pro Asn Ala 
                245                 250                 255     


Arg Arg Ile Lys Lys Lys Lys Ser Lys Pro Pro Glu Lys Val 
            260                 265                 270 


<210> 5852
<211> 474
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(434)
<223> Selenocysteine

<400> 5852
Met Ala Ala Ala Ser Val Ser Ala Ala Ser Gly Ser His Leu Ser Asn 
1               5                   10                  15      


Ser Phe Ala Glu Pro Ser Arg Ser Asn Gly Ser Met Val Arg His Ser 
            20                  25                  30          


Ser Ser Pro Tyr Val Val Tyr Pro Ser Asp Lys Pro Phe Leu Asn Ser 
        35                  40                  45              


Asp Leu Arg Arg Ser Pro Ser Lys Pro Xaa Leu Ala Tyr Pro Glu Ser 
    50                  55                  60                  


Asn Ser Arg Ala Ile Phe Ser Ala Leu Lys Asn Leu Gln Asp Lys Ile 
65                  70                  75                  80  


Arg Arg Leu Glu Leu Glu Arg Ile Gln Ala Glu Glu Ser Val Lys Xaa 
                85                  90                  95      


Leu Ser Arg Glu Xaa Ile Glu Tyr Lys Lys Val Leu Asp Glu Gln Ile 
            100                 105                 110         


Gln Glu Arg Glu Asn Ser Lys Asn Glu Glu Ser Lys His Asn Gln Glu 
        115                 120                 125             


Leu Xaa Ser Gln Leu Leu Ala Ala Glu Asn Lys Cys Asn Leu Leu Glu 
    130                 135                 140                 


Lys Gln Leu Glu Tyr Met Arg Asn Met Ile Lys His Ala Glu Met Glu 
145                 150                 155                 160 


Arg Xaa Ser Val Leu Glu Lys Gln Val Ser Leu Glu Arg Glu Arg Gln 
                165                 170                 175     


His Asp Gln Xaa His Val Gln Ser Gln Leu Glu Lys Leu Asp Leu Leu 
            180                 185                 190         


Glu Gln Glu Tyr Asn Lys Leu Xaa Xaa Met Gln Ala Leu Ala Glu Lys 
        195                 200                 205             


Lys Met Gln Glu Leu Glu Ala Lys Leu His Glu Glu Glu Gln Glu Arg 
    210                 215                 220                 


Lys Arg Met Gln Ala Lys Ala Ala Glu Leu Gln Xaa Gly Leu Glu Xaa 
225                 230                 235                 240 


Asn Arg Leu Ile Phe Glu Asp Lys Ala Xaa Pro Cys Val Pro Asn Ala 
                245                 250                 255     


Arg Arg Ile Lys Lys Lys Lys Ser Lys Pro Pro Glu Lys Ser Xaa Ser 
            260                 265                 270         


Pro Ser His Ala Val Val Ala Asn Val Gln Leu Val Leu His Leu Met 
        275                 280                 285             


Lys Gln His Ser Lys Ala Leu Cys Asn Asp Arg Val Ile Asn Ser Ile 
    290                 295                 300                 


Pro Leu Ala Lys Gln Val Ser Ser Arg Gly Gly Lys Ser Lys Lys Leu 
305                 310                 315                 320 


Ser Val Xaa Pro Pro Ser Ser Asn Gly Ile Asn Glu Glu Leu Ser Glu 
                325                 330                 335     


Val Leu Gln Xaa Leu Gln Asp Glu Phe Gly Gln Met Ser Phe Asp His 
            340                 345                 350         


Gln Gln Leu Ala Lys Leu Ile Gln Glu Ser Pro Xaa Val Glu Leu Lys 
        355                 360                 365             


Asp Lys Leu Glu Cys Glu Leu Glu Ala Leu Val Gly Arg Met Glu Ala 
    370                 375                 380                 


Lys Ala Asn Gln Ile Xaa Lys Val Arg Lys Tyr Gln Ala Gln Leu Glu 
385                 390                 395                 400 


Lys Gln Lys Leu Glu Lys Gln Lys Lys Glu Leu Lys Ala Xaa Lys Lys 
                405                 410                 415     


Xaa Leu Asp Glu Glu Arg Asn Ser Ser Ser Arg Ser Gly Ile Xaa Gly 
            420                 425                 430         


Xaa Xaa Asn Lys Lys Asp Phe Met Lys Leu Arg Pro Gly Glu Lys Arg 
        435                 440                 445             


Arg Lys Asn Leu Gln Leu Leu Lys Asp Met Gln Ser Ile Gln Asn Ser 
    450                 455                 460                 


Leu Gln Ser Ser Ser Leu Cys Trp Asp Tyr 
465                 470                 


<210> 5853
<211> 500
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(460)
<223> Selenocysteine

<400> 5853
Met Ala Ala Ala Ser Val Ser Ala Ala Ser Gly Ser His Leu Ser Asn 
1               5                   10                  15      


Ser Phe Ala Glu Pro Ser Arg Ser Asn Gly Ser Met Val Arg His Ser 
            20                  25                  30          


Ser Ser Pro Tyr Val Val Tyr Pro Ser Asp Lys Pro Phe Leu Asn Ser 
        35                  40                  45              


Asp Leu Arg Arg Ser Pro Ser Lys Pro Xaa Leu Ala Tyr Pro Glu Ser 
    50                  55                  60                  


Asn Ser Arg Ala Ile Phe Ser Ala Leu Lys Asn Leu Gln Asp Lys Ile 
65                  70                  75                  80  


Arg Arg Leu Glu Leu Glu Arg Ile Gln Ala Glu Glu Ser Val Lys Xaa 
                85                  90                  95      


Leu Ser Arg Glu Xaa Ile Glu Tyr Lys Lys Val Leu Asp Glu Gln Ile 
            100                 105                 110         


Gln Glu Arg Glu Asn Ser Lys Asn Glu Glu Ser Lys His Asn Gln Glu 
        115                 120                 125             


Leu Xaa Ser Gln Leu Leu Ala Ala Glu Asn Lys Cys Asn Leu Leu Glu 
    130                 135                 140                 


Lys Gln Leu Glu Tyr Met Arg Asn Met Ile Lys His Ala Glu Met Glu 
145                 150                 155                 160 


Arg Xaa Ser Val Leu Glu Lys Gln Val Ser Leu Glu Arg Glu Arg Gln 
                165                 170                 175     


His Asp Gln Xaa His Val Gln Ser Gln Leu Glu Lys Leu Asp Leu Leu 
            180                 185                 190         


Glu Gln Glu Tyr Asn Lys Leu Xaa Xaa Met Gln Ala Leu Ala Glu Lys 
        195                 200                 205             


Lys Met Gln Glu Leu Glu Ala Lys Leu His Glu Glu Glu Gln Glu Arg 
    210                 215                 220                 


Lys Arg Met Gln Ala Lys Ala Ala Glu Leu Gln Xaa Gly Leu Glu Xaa 
225                 230                 235                 240 


Asn Arg Leu Ile Phe Glu Asp Lys Ala Xaa Pro Cys Val Pro Asn Ala 
                245                 250                 255     


Arg Arg Ile Lys Lys Lys Lys Ser Lys Pro Pro Glu Lys Lys Ser Ser 
            260                 265                 270         


Arg Asn Tyr Phe Gly Ala Gln Pro His Tyr Arg Leu Cys Leu Gly Asp 
        275                 280                 285             


Met Pro Phe Val Ala Gly Lys Ser Xaa Ser Pro Ser His Ala Val Val 
    290                 295                 300                 


Ala Asn Val Gln Leu Val Leu His Leu Met Lys Gln His Ser Lys Ala 
305                 310                 315                 320 


Leu Cys Asn Asp Arg Val Ile Asn Ser Ile Pro Leu Ala Lys Gln Val 
                325                 330                 335     


Ser Ser Arg Gly Gly Lys Ser Lys Lys Leu Ser Val Xaa Pro Pro Ser 
            340                 345                 350         


Ser Asn Gly Ile Asn Glu Glu Leu Ser Glu Val Leu Gln Xaa Leu Gln 
        355                 360                 365             


Asp Glu Phe Gly Gln Met Ser Phe Asp His Gln Gln Leu Ala Lys Leu 
    370                 375                 380                 


Ile Gln Glu Ser Pro Xaa Val Glu Leu Lys Asp Lys Leu Glu Cys Glu 
385                 390                 395                 400 


Leu Glu Ala Leu Val Gly Arg Met Glu Ala Lys Ala Asn Gln Ile Xaa 
                405                 410                 415     


Lys Val Arg Lys Tyr Gln Ala Gln Leu Glu Lys Gln Lys Leu Glu Lys 
            420                 425                 430         


Gln Lys Lys Glu Leu Lys Ala Xaa Lys Lys Xaa Leu Asp Glu Glu Arg 
        435                 440                 445             


Asn Ser Ser Ser Arg Ser Gly Ile Xaa Gly Xaa Xaa Asn Lys Lys Asp 
    450                 455                 460                 


Phe Met Lys Leu Arg Pro Gly Glu Lys Arg Arg Lys Asn Leu Gln Leu 
465                 470                 475                 480 


Leu Lys Asp Met Gln Ser Ile Gln Asn Ser Leu Gln Ser Ser Ser Leu 
                485                 490                 495     


Cys Trp Asp Tyr 
            500 


<210> 5854
<211> 82
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<400> 5854
Met Ala Ala Ala Ser Val Ser Ala Ala Ser Gly Ser His Leu Ser Asn 
1               5                   10                  15      


Ser Phe Ala Glu Pro Ser Arg Ser Asn Gly Ser Met Val Arg His Ser 
            20                  25                  30          


Ser Ser Pro Tyr Val Val Tyr Pro Ser Asp Lys Pro Phe Leu Asn Ser 
        35                  40                  45              


Asp Leu Arg Arg Ser Pro Ser Lys Pro Xaa Leu Ala Tyr Pro Glu Ser 
    50                  55                  60                  


Asn Ser Arg Ala Ser Xaa Phe Val Phe Val Phe Gly Ser His Ile Phe 
65                  70                  75                  80  


Cys Ser 
        


<210> 5855
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<400> 5855
Met Ala Ala Ala Ser Val Ser Ala Ala Ser Gly Ser His Leu Ser Asn 
1               5                   10                  15      


Ser Phe Ala Glu Pro Ser Arg Ser Asn Gly Ser Met Val Arg His Ser 
            20                  25                  30          


Ser Ser Pro Tyr Val Val Tyr Pro Ser Asp Lys Pro Phe Leu Asn Ser 
        35                  40                  45              


Asp Leu Arg Arg Ser Pro Ser Lys Pro Xaa Leu Ala Tyr Pro Glu Ser 
    50                  55                  60                  


Asn Ser Arg Glu Ser Ser Arg 
65                  70      


<210> 5856
<211> 41
<212> PRT
<213> Homo sapiens

<400> 5856
Met Ala Ala Ala Ser Val Ser Ala Ala Ser Gly Ser His Leu Ser Pro 
1               5                   10                  15      


Tyr Phe Leu Leu Leu Arg Ile Phe Lys Ile Arg Phe Asp Ala Trp Asn 
            20                  25                  30          


Leu Arg Gly Phe Arg Gln Lys Lys Val 
        35                  40      


<210> 5857
<211> 52
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<400> 5857
Met Ala Ala Ala Ser Val Ser Ala Ala Ser Gly Ser His Leu Ser Xaa 
1               5                   10                  15      


Arg Gly Trp Ala Leu Asp Tyr Ser Ser Val Val Gly His Gly Ile Cys 
            20                  25                  30          


Xaa Val Xaa Gln Pro Val Ser Phe Ser Arg Lys Lys Arg Glu Lys Ile 
        35                  40                  45              


Val Gln Gln Ile 
    50          


<210> 5858
<211> 198
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(192)
<223> Selenocysteine

<400> 5858
Met Leu Xaa Arg Ile Asp Asn Ser Phe Ala Glu Pro Ser Arg Ser Asn 
1               5                   10                  15      


Gly Ser Met Val Arg His Ser Ser Ser Pro Tyr Val Val Tyr Pro Ser 
            20                  25                  30          


Asp Lys Pro Phe Leu Asn Ser Asp Leu Arg Arg Ser Pro Ser Lys Pro 
        35                  40                  45              


Xaa Leu Ala Tyr Pro Glu Ser Asn Ser Arg Ala Ile Phe Ser Ala Leu 
    50                  55                  60                  


Lys Asn Leu Gln Asp Lys Ile Arg Arg Leu Glu Leu Glu Arg Ile Gln 
65                  70                  75                  80  


Ala Glu Glu Ser Val Lys Xaa Leu Ser Arg Glu Xaa Ile Glu Tyr Lys 
                85                  90                  95      


Lys Val Leu Asp Glu Gln Ile Gln Glu Arg Glu Asn Ser Lys Asn Glu 
            100                 105                 110         


Glu Ser Lys His Asn Gln Glu Leu Xaa Ser Gln Leu Leu Ala Ala Glu 
        115                 120                 125             


Asn Lys Cys Asn Leu Leu Glu Lys Gln Leu Glu Tyr Met Arg Asn Met 
    130                 135                 140                 


Ile Lys His Ala Glu Met Glu Arg Xaa Ser Val Leu Glu Lys Gln Val 
145                 150                 155                 160 


Ser Leu Glu Arg Glu Arg Gln His Asp Gln Xaa His Val Gln Ser Gln 
                165                 170                 175     


Leu Glu Lys Leu Asp Leu Leu Glu Gln Glu Tyr Asn Lys Leu Xaa Xaa 
            180                 185                 190         


Met Gln Ala Leu Ala Glu 
        195             


<210> 5859
<211> 491
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(451)
<223> Selenocysteine

<400> 5859
Met Leu Xaa Arg Ile Asp Asn Ser Phe Ala Glu Pro Ser Arg Ser Asn 
1               5                   10                  15      


Gly Ser Met Val Arg His Ser Ser Ser Pro Tyr Val Val Tyr Pro Ser 
            20                  25                  30          


Asp Lys Pro Phe Leu Asn Ser Asp Leu Arg Arg Ser Pro Ser Lys Pro 
        35                  40                  45              


Xaa Leu Ala Tyr Pro Glu Ser Asn Ser Arg Ala Ile Phe Ser Ala Leu 
    50                  55                  60                  


Lys Asn Leu Gln Asp Lys Ile Arg Arg Leu Glu Leu Glu Arg Ile Gln 
65                  70                  75                  80  


Ala Glu Glu Ser Val Lys Xaa Leu Ser Arg Glu Xaa Ile Glu Tyr Lys 
                85                  90                  95      


Lys Val Leu Asp Glu Gln Ile Gln Glu Arg Glu Asn Ser Lys Asn Glu 
            100                 105                 110         


Glu Ser Lys His Asn Gln Glu Leu Xaa Ser Gln Leu Leu Ala Ala Glu 
        115                 120                 125             


Asn Lys Cys Asn Leu Leu Glu Lys Gln Leu Glu Tyr Met Arg Asn Met 
    130                 135                 140                 


Ile Lys His Ala Glu Met Glu Arg Xaa Ser Val Leu Glu Lys Gln Val 
145                 150                 155                 160 


Ser Leu Glu Arg Glu Arg Gln His Asp Gln Xaa His Val Gln Ser Gln 
                165                 170                 175     


Leu Glu Lys Leu Asp Leu Leu Glu Gln Glu Tyr Asn Lys Leu Xaa Xaa 
            180                 185                 190         


Met Gln Ala Leu Ala Glu Lys Lys Met Gln Glu Leu Glu Ala Lys Leu 
        195                 200                 205             


His Glu Glu Glu Gln Glu Arg Lys Arg Met Gln Ala Lys Ala Ala Glu 
    210                 215                 220                 


Leu Gln Xaa Gly Leu Glu Xaa Asn Arg Leu Ile Phe Glu Asp Lys Ala 
225                 230                 235                 240 


Xaa Pro Cys Val Pro Asn Ala Arg Arg Ile Lys Lys Lys Lys Ser Lys 
                245                 250                 255     


Pro Pro Glu Lys Lys Ser Ser Arg Asn Tyr Phe Gly Ala Gln Pro His 
            260                 265                 270         


Tyr Arg Leu Cys Leu Gly Asp Met Pro Phe Val Ala Gly Lys Ser Xaa 
        275                 280                 285             


Ser Pro Ser His Ala Val Val Ala Asn Val Gln Leu Val Leu His Leu 
    290                 295                 300                 


Met Lys Gln His Ser Lys Ala Leu Cys Asn Asp Arg Val Ile Asn Ser 
305                 310                 315                 320 


Ile Pro Leu Ala Lys Gln Val Ser Ser Arg Gly Gly Lys Ser Lys Lys 
                325                 330                 335     


Leu Ser Val Xaa Pro Pro Ser Ser Asn Gly Ile Asn Glu Glu Leu Ser 
            340                 345                 350         


Glu Val Leu Gln Xaa Leu Gln Asp Glu Phe Gly Gln Met Ser Phe Asp 
        355                 360                 365             


His Gln Gln Leu Ala Lys Leu Ile Gln Glu Ser Pro Xaa Val Glu Leu 
    370                 375                 380                 


Lys Asp Lys Leu Glu Cys Glu Leu Glu Ala Leu Val Gly Arg Met Glu 
385                 390                 395                 400 


Ala Lys Ala Asn Gln Ile Xaa Lys Val Arg Lys Tyr Gln Ala Gln Leu 
                405                 410                 415     


Glu Lys Gln Lys Leu Glu Lys Gln Lys Lys Glu Leu Lys Ala Xaa Lys 
            420                 425                 430         


Lys Xaa Leu Asp Glu Glu Arg Asn Ser Ser Ser Arg Ser Gly Ile Xaa 
        435                 440                 445             


Gly Xaa Xaa Asn Lys Lys Asp Phe Met Lys Leu Arg Pro Gly Glu Lys 
    450                 455                 460                 


Arg Arg Lys Asn Leu Gln Leu Leu Lys Asp Met Gln Ser Ile Gln Asn 
465                 470                 475                 480 


Ser Leu Gln Ser Ser Ser Leu Cys Trp Asp Tyr 
                485                 490     


<210> 5860
<211> 205
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(174)
<223> Selenocysteine

<400> 5860
Met Val Arg His Ser Ser Ser Pro Tyr Val Val Tyr Pro Ser Asp Lys 
1               5                   10                  15      


Pro Phe Leu Asn Ser Asp Leu Arg Arg Ser Pro Ser Lys Pro Xaa Leu 
            20                  25                  30          


Ala Tyr Pro Glu Ser Asn Ser Arg Ala Ile Phe Ser Ala Leu Lys Asn 
        35                  40                  45              


Leu Gln Asp Lys Ile Arg Arg Leu Glu Leu Glu Arg Ile Gln Ala Glu 
    50                  55                  60                  


Glu Ser Val Lys Xaa Leu Ser Arg Glu Xaa Ile Glu Tyr Lys Lys Val 
65                  70                  75                  80  


Leu Asp Glu Gln Ile Gln Glu Arg Glu Asn Ser Lys Asn Glu Glu Ser 
                85                  90                  95      


Lys His Asn Gln Glu Leu Xaa Ser Gln Leu Leu Ala Ala Glu Asn Lys 
            100                 105                 110         


Cys Asn Leu Leu Glu Lys Gln Leu Glu Tyr Met Arg Asn Met Ile Lys 
        115                 120                 125             


His Ala Glu Met Glu Arg Xaa Ser Val Leu Glu Lys Gln Val Ser Leu 
    130                 135                 140                 


Glu Arg Glu Arg Gln His Asp Gln Xaa His Val Gln Ser Gln Leu Glu 
145                 150                 155                 160 


Lys Leu Asp Leu Leu Glu Gln Glu Tyr Asn Lys Leu Xaa Xaa Met Gln 
                165                 170                 175     


Ala Leu Ala Glu Lys Lys Met Gln Glu Leu Glu Ala Lys Leu His Glu 
            180                 185                 190         


Glu Glu Gln Glu Arg Lys Arg Met Gln Ala Lys Ala Ala 
        195                 200                 205 


<210> 5861
<211> 473
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(433)
<223> Selenocysteine

<400> 5861
Met Val Arg His Ser Ser Ser Pro Tyr Val Val Tyr Pro Ser Asp Lys 
1               5                   10                  15      


Pro Phe Leu Asn Ser Asp Leu Arg Arg Ser Pro Ser Lys Pro Xaa Leu 
            20                  25                  30          


Ala Tyr Pro Glu Ser Asn Ser Arg Ala Ile Phe Ser Ala Leu Lys Asn 
        35                  40                  45              


Leu Gln Asp Lys Ile Arg Arg Leu Glu Leu Glu Arg Ile Gln Ala Glu 
    50                  55                  60                  


Glu Ser Val Lys Xaa Leu Ser Arg Glu Xaa Ile Glu Tyr Lys Lys Val 
65                  70                  75                  80  


Leu Asp Glu Gln Ile Gln Glu Arg Glu Asn Ser Lys Asn Glu Glu Ser 
                85                  90                  95      


Lys His Asn Gln Glu Leu Xaa Ser Gln Leu Leu Ala Ala Glu Asn Lys 
            100                 105                 110         


Cys Asn Leu Leu Glu Lys Gln Leu Glu Tyr Met Arg Asn Met Ile Lys 
        115                 120                 125             


His Ala Glu Met Glu Arg Xaa Ser Val Leu Glu Lys Gln Val Ser Leu 
    130                 135                 140                 


Glu Arg Glu Arg Gln His Asp Gln Xaa His Val Gln Ser Gln Leu Glu 
145                 150                 155                 160 


Lys Leu Asp Leu Leu Glu Gln Glu Tyr Asn Lys Leu Xaa Xaa Met Gln 
                165                 170                 175     


Ala Leu Ala Glu Lys Lys Met Gln Glu Leu Glu Ala Lys Leu His Glu 
            180                 185                 190         


Glu Glu Gln Glu Arg Lys Arg Met Gln Ala Lys Ala Ala Glu Leu Gln 
        195                 200                 205             


Xaa Gly Leu Glu Xaa Asn Arg Leu Ile Phe Glu Asp Lys Ala Xaa Pro 
    210                 215                 220                 


Cys Val Pro Asn Ala Arg Arg Ile Lys Lys Lys Lys Ser Lys Pro Pro 
225                 230                 235                 240 


Glu Lys Lys Ser Ser Arg Asn Tyr Phe Gly Ala Gln Pro His Tyr Arg 
                245                 250                 255     


Leu Cys Leu Gly Asp Met Pro Phe Val Ala Gly Lys Ser Xaa Ser Pro 
            260                 265                 270         


Ser His Ala Val Val Ala Asn Val Gln Leu Val Leu His Leu Met Lys 
        275                 280                 285             


Gln His Ser Lys Ala Leu Cys Asn Asp Arg Val Ile Asn Ser Ile Pro 
    290                 295                 300                 


Leu Ala Lys Gln Val Ser Ser Arg Gly Gly Lys Ser Lys Lys Leu Ser 
305                 310                 315                 320 


Val Xaa Pro Pro Ser Ser Asn Gly Ile Asn Glu Glu Leu Ser Glu Val 
                325                 330                 335     


Leu Gln Xaa Leu Gln Asp Glu Phe Gly Gln Met Ser Phe Asp His Gln 
            340                 345                 350         


Gln Leu Ala Lys Leu Ile Gln Glu Ser Pro Xaa Val Glu Leu Lys Asp 
        355                 360                 365             


Lys Leu Glu Cys Glu Leu Glu Ala Leu Val Gly Arg Met Glu Ala Lys 
    370                 375                 380                 


Ala Asn Gln Ile Xaa Lys Val Arg Lys Tyr Gln Ala Gln Leu Glu Lys 
385                 390                 395                 400 


Gln Lys Leu Glu Lys Gln Lys Lys Glu Leu Lys Ala Xaa Lys Lys Xaa 
                405                 410                 415     


Leu Asp Glu Glu Arg Asn Ser Ser Ser Arg Ser Gly Ile Xaa Gly Xaa 
            420                 425                 430         


Xaa Asn Lys Lys Asp Phe Met Lys Leu Arg Pro Gly Glu Lys Arg Arg 
        435                 440                 445             


Lys Asn Leu Gln Leu Leu Lys Asp Met Gln Ser Ile Gln Asn Ser Leu 
    450                 455                 460                 


Gln Ser Ser Ser Leu Cys Trp Asp Tyr 
465                 470             


<210> 5862
<211> 134
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<400> 5862
Xaa His Val Gln Ser Gln Leu Glu Lys Leu Asp Leu Leu Glu Gln Glu 
1               5                   10                  15      


Tyr Asn Lys Leu Xaa Xaa Met Gln Ala Leu Ala Glu Lys Lys Met Gln 
            20                  25                  30          


Glu Leu Glu Ala Lys Leu His Glu Glu Glu Gln Glu Arg Lys Arg Met 
        35                  40                  45              


Gln Ala Lys Ala Ala Glu Ser Xaa Ser Pro Ser His Ala Val Val Ala 
    50                  55                  60                  


Asn Val Gln Leu Val Leu His Leu Met Lys Gln His Ser Lys Ala Leu 
65                  70                  75                  80  


Cys Asn Asp Arg Val Ile Asn Ser Ile Pro Leu Ala Lys Gln Val Ser 
                85                  90                  95      


Ser Arg Gly Gly Lys Ser Lys Lys Leu Ser Val Xaa Pro Pro Ser Ser 
            100                 105                 110         


Asn Gly Ile Asn Glu Glu Leu Ser Glu Val Leu Gln Xaa Leu Gln Asp 
        115                 120                 125             


Glu Phe Gly Gln Met Ser 
    130                 


<210> 5863
<211> 254
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(250)
<223> Selenocysteine

<400> 5863
Xaa Leu Glu Lys Leu Asp Leu Leu Glu Gln Glu Tyr Asn Lys Leu Xaa 
1               5                   10                  15      


Xaa Met Gln Ala Leu Ala Glu Lys Lys Met Gln Glu Leu Glu Ala Lys 
            20                  25                  30          


Leu His Glu Glu Glu Gln Glu Arg Lys Arg Met Gln Ala Lys Ala Ala 
        35                  40                  45              


Glu Leu Gln Xaa Gly Leu Glu Xaa Asn Arg Leu Ile Phe Glu Asp Lys 
    50                  55                  60                  


Ala Xaa Pro Cys Val Pro Asn Ala Arg Arg Ile Lys Lys Lys Lys Ser 
65                  70                  75                  80  


Lys Pro Pro Glu Lys Ser Xaa Ser Pro Ser His Ala Val Val Ala Asn 
                85                  90                  95      


Val Gln Leu Val Leu His Leu Met Lys Gln His Ser Lys Ala Leu Cys 
            100                 105                 110         


Asn Asp Arg Val Ile Asn Ser Ile Pro Leu Ala Lys Gln Val Ser Ser 
        115                 120                 125             


Arg Gly Gly Lys Ser Lys Lys Leu Ser Val Xaa Pro Pro Ser Ser Asn 
    130                 135                 140                 


Gly Ile Asn Glu Glu Leu Ser Glu Val Leu Gln Xaa Leu Gln Asp Glu 
145                 150                 155                 160 


Phe Gly Gln Met Ser Phe Asp His Gln Gln Leu Ala Lys Leu Ile Gln 
                165                 170                 175     


Glu Ser Pro Xaa Val Glu Leu Lys Asp Lys Leu Glu Cys Glu Leu Glu 
            180                 185                 190         


Ala Leu Val Gly Arg Met Glu Ala Lys Ala Asn Gln Ile Xaa Lys Val 
        195                 200                 205             


Arg Lys Tyr Gln Ala Gln Leu Glu Lys Gln Lys Leu Glu Lys Gln Lys 
    210                 215                 220                 


Lys Glu Leu Lys Ala Xaa Lys Lys Xaa Leu Asp Glu Glu Arg Asn Ser 
225                 230                 235                 240 


Ser Ser Arg Ser Gly Ile Xaa Gly Xaa Xaa Asn Lys Lys Asp 
                245                 250                 


<210> 5864
<211> 194
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<400> 5864
Asp Leu Asp Ser Val Leu Ser Gln Leu Asn Phe Xaa His Xaa Ser Glu 
1               5                   10                  15      


Asp Leu Leu Gln Ala Glu Val Xaa Cys Leu Glu Gly Ser Leu Glu Ser 
            20                  25                  30          


Val Ser Ala Xaa Cys Lys Gln Leu Ser Gln Glu Leu Met Glu Lys Tyr 
        35                  40                  45              


Glu Glu Leu Lys Arg Met Glu Ala His Asn Asn Glu Tyr Lys Ala Glu 
    50                  55                  60                  


Ile Lys Lys Leu Lys Glu Gln Ile Leu Gln Gly Glu Gln Ser Tyr Ser 
65                  70                  75                  80  


Ser Ala Leu Glu Gly Met Lys Met Glu Ile Ser His Leu Xaa Gln Glu 
                85                  90                  95      


Leu His Gln Arg Asp Ile Xaa Ile Ala Ser Xaa Lys Gly Ser Ser Ser 
            100                 105                 110         


Asp Met Glu Lys Arg Leu Arg Ala Glu Met Gln Lys Ala Glu Asp Lys 
        115                 120                 125             


Ala Val Glu His Lys Glu Ile Leu Asp Gln Leu Glu Ser Leu Lys Leu 
    130                 135                 140                 


Glu Asn Arg His Leu Ser Glu Met Val Met Lys Leu Glu Leu Gly Leu 
145                 150                 155                 160 


His Glu Arg Trp Gly Phe Xaa Met Leu Ser Ser Leu Val Leu Asn Phe 
                165                 170                 175     


Gly Ile Gln Ala Ile Arg Gln Pro Gln Arg Pro Lys Val Leu Glu Leu 
            180                 185                 190         


Gln Val 
        


<210> 5865
<211> 63
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 5865
Met Glu Ala Leu Leu Glu Gly Ile Gln Asn Arg Gly His Gly Gly Gly 
1               5                   10                  15      


Phe Leu Xaa Ser Cys Glu Ala Glu Leu Gln Glu Leu Met Lys Gln Ile 
            20                  25                  30          


Asp Ile Met Val Ala His Lys Lys Ser Glu Trp Glu Gly Arg Xaa His 
        35                  40                  45              


Ala Leu Glu Xaa Cys Leu Lys Ile Arg Glu Gln Glu Leu Lys Ser 
    50                  55                  60              


<210> 5866
<211> 162
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<400> 5866
Met Glu Ala Leu Leu Glu Gly Ile Gln Asn Arg Gly His Gly Gly Gly 
1               5                   10                  15      


Phe Leu Xaa Ser Cys Glu Ala Glu Leu Gln Glu Leu Met Lys Gln Ile 
            20                  25                  30          


Asp Ile Met Val Ala His Lys Lys Ser Glu Trp Glu Gly Arg Xaa His 
        35                  40                  45              


Ala Leu Glu Xaa Cys Leu Lys Ile Arg Glu Gln Glu Leu Lys Ser Leu 
    50                  55                  60                  


Arg Ser Gln Leu Asp Val Xaa His Lys Glu Val Gly Met Leu His Gln 
65                  70                  75                  80  


Gln Val Glu Glu His Glu Lys Ile Lys Gln Glu Met Xaa Met Glu Tyr 
                85                  90                  95      


Lys Gln Glu Leu Lys Lys Leu His Glu Glu Leu Cys Ile Leu Lys Arg 
            100                 105                 110         


Ser Tyr Glu Lys Leu Gln Lys Lys Gln Met Arg Glu Phe Arg Gly Asn 
        115                 120                 125             


Xaa Lys Asn His Arg Glu Asp Arg Ser Glu Ile Glu Arg Leu Xaa Ala 
    130                 135                 140                 


Lys Ile Glu Glu Phe Arg Gln Lys Ser Leu Asp Trp Glu Lys Gln Arg 
145                 150                 155                 160 


Leu Ile 
        


<210> 5867
<211> 475
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<400> 5867
Met Glu Ala Leu Leu Glu Gly Ile Gln Asn Arg Gly His Gly Gly Gly 
1               5                   10                  15      


Phe Leu Xaa Ser Cys Glu Ala Glu Leu Gln Glu Leu Met Lys Gln Ile 
            20                  25                  30          


Asp Ile Met Val Ala His Lys Lys Ser Glu Trp Glu Gly Arg Xaa His 
        35                  40                  45              


Ala Leu Glu Xaa Cys Leu Lys Ile Arg Glu Gln Glu Leu Lys Ser Leu 
    50                  55                  60                  


Arg Ser Gln Leu Asp Val Xaa His Lys Glu Val Gly Met Leu His Gln 
65                  70                  75                  80  


Gln Val Glu Glu His Glu Lys Ile Lys Gln Glu Met Xaa Met Glu Tyr 
                85                  90                  95      


Lys Gln Glu Leu Lys Lys Leu His Glu Glu Leu Cys Ile Leu Lys Arg 
            100                 105                 110         


Ser Tyr Glu Lys Leu Gln Lys Lys Gln Met Arg Glu Phe Arg Gly Asn 
        115                 120                 125             


Xaa Lys Asn His Arg Glu Asp Arg Ser Glu Ile Glu Arg Leu Xaa Ala 
    130                 135                 140                 


Lys Ile Glu Glu Phe Arg Gln Lys Ser Leu Asp Trp Glu Lys Gln Arg 
145                 150                 155                 160 


Leu Ile Tyr Gln Gln Gln Val Ser Ser Leu Glu Ala Gln Arg Lys Ala 
                165                 170                 175     


Leu Ala Glu Gln Ser Glu Ile Ile Gln Ala Gln Leu Val Asn Arg Lys 
            180                 185                 190         


Gln Lys Leu Glu Ser Val Glu Leu Ser Ser Gln Ser Glu Ile Gln His 
        195                 200                 205             


Leu Ser Ser Lys Leu Glu Arg Ala Asn Asp Xaa Ile Cys Ala Asn Glu 
    210                 215                 220                 


Leu Glu Ile Glu Arg Leu Xaa Met Arg Val Asn Asp Leu Val Gly Xaa 
225                 230                 235                 240 


Ser Met Xaa Val Leu Gln Glu Gln Gln Gln Lys Glu Glu Lys Leu Arg 
                245                 250                 255     


Glu Ser Glu Lys Leu Leu Glu Ala Leu Gln Glu Glu Lys Arg Glu Leu 
            260                 265                 270         


Lys Ala Ala Leu Gln Ser Gln Glu Asn Leu Ile His Glu Ala Arg Ile 
        275                 280                 285             


Gln Lys Glu Lys Leu Gln Glu Lys Val Lys Ala Xaa Asn Xaa Gln His 
    290                 295                 300                 


Ala Val Glu Ala Ile Ser Leu Glu Ser Val Ser Ala Xaa Cys Lys Gln 
305                 310                 315                 320 


Leu Ser Gln Glu Leu Met Glu Lys Tyr Glu Glu Leu Lys Arg Met Glu 
                325                 330                 335     


Ala His Asn Asn Glu Tyr Lys Ala Glu Ile Lys Lys Leu Lys Glu Gln 
            340                 345                 350         


Ile Leu Gln Gly Glu Gln Ser Tyr Ser Ser Ala Leu Glu Gly Met Lys 
        355                 360                 365             


Met Glu Ile Ser His Leu Xaa Gln Glu Leu His Gln Arg Asp Ile Xaa 
    370                 375                 380                 


Ile Ala Ser Xaa Lys Gly Ser Ser Ser Asp Met Glu Lys Arg Leu Arg 
385                 390                 395                 400 


Ala Glu Met Gln Lys Ala Glu Asp Lys Ala Val Glu His Lys Glu Ile 
                405                 410                 415     


Leu Asp Gln Leu Glu Ser Leu Lys Leu Glu Asn Arg His Leu Ser Glu 
            420                 425                 430         


Met Val Met Lys Leu Glu Leu Gly Leu His Glu Arg Trp Gly Phe Xaa 
        435                 440                 445             


Met Leu Ser Ser Leu Val Leu Asn Phe Gly Ile Gln Ala Ile Arg Gln 
    450                 455                 460                 


Pro Gln Arg Pro Lys Val Leu Glu Leu Gln Val 
465                 470                 475 


<210> 5868
<211> 495
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<400> 5868
Met Glu Ala Leu Leu Glu Gly Ile Gln Asn Arg Gly His Gly Gly Gly 
1               5                   10                  15      


Phe Leu Xaa Ser Cys Glu Ala Glu Leu Gln Glu Leu Met Lys Gln Ile 
            20                  25                  30          


Asp Ile Met Val Ala His Lys Lys Ser Glu Trp Glu Gly Arg Xaa His 
        35                  40                  45              


Ala Leu Glu Xaa Cys Leu Lys Ile Arg Glu Gln Glu Leu Lys Ser Leu 
    50                  55                  60                  


Arg Ser Gln Leu Asp Val Xaa His Lys Glu Val Gly Met Leu His Gln 
65                  70                  75                  80  


Gln Val Glu Glu His Glu Lys Ile Lys Gln Glu Met Xaa Met Glu Tyr 
                85                  90                  95      


Lys Gln Glu Leu Lys Lys Leu His Glu Glu Leu Cys Ile Leu Lys Arg 
            100                 105                 110         


Ser Tyr Glu Lys Leu Gln Lys Lys Gln Met Arg Glu Phe Arg Gly Asn 
        115                 120                 125             


Xaa Lys Asn His Arg Glu Asp Arg Ser Glu Ile Glu Arg Leu Xaa Ala 
    130                 135                 140                 


Lys Ile Glu Glu Phe Arg Gln Lys Ser Leu Asp Trp Glu Lys Gln Arg 
145                 150                 155                 160 


Leu Ile Tyr Gln Gln Gln Val Ser Ser Leu Glu Ala Gln Arg Lys Ala 
                165                 170                 175     


Leu Ala Glu Gln Ser Glu Ile Ile Gln Ala Gln Leu Val Asn Arg Lys 
            180                 185                 190         


Gln Lys Leu Glu Ser Val Glu Leu Ser Ser Gln Ser Glu Ile Gln His 
        195                 200                 205             


Leu Ser Ser Lys Leu Glu Arg Ala Asn Asp Xaa Ile Cys Ala Asn Glu 
    210                 215                 220                 


Leu Glu Ile Glu Arg Leu Xaa Met Arg Val Asn Asp Leu Val Gly Xaa 
225                 230                 235                 240 


Ser Met Xaa Val Leu Gln Glu Gln Gln Gln Lys Glu Glu Lys Leu Arg 
                245                 250                 255     


Glu Ser Glu Lys Leu Leu Glu Ala Leu Gln Glu Glu Lys Arg Glu Leu 
            260                 265                 270         


Lys Ala Ala Leu Gln Ser Gln Glu Asn Leu Ile His Glu Ala Arg Ile 
        275                 280                 285             


Gln Lys Glu Lys Leu Gln Glu Lys Val Lys Ala Xaa Asn Xaa Gln His 
    290                 295                 300                 


Ala Val Glu Ala Ile Ser Leu Glu Ser Val Ser Ala Xaa Cys Lys Gln 
305                 310                 315                 320 


Leu Ser Gln Glu Leu Met Glu Lys Tyr Glu Glu Leu Lys Arg Met Glu 
                325                 330                 335     


Ala His Asn Asn Glu Tyr Lys Ala Glu Ile Lys Lys Leu Lys Glu Gln 
            340                 345                 350         


Ile Leu Gln Gly Glu Gln Ser Tyr Ser Ser Ala Leu Glu Gly Met Lys 
        355                 360                 365             


Met Glu Ile Ser His Leu Xaa Gln Glu Leu His Gln Arg Asp Ile Xaa 
    370                 375                 380                 


Ile Ala Ser Xaa Lys Gly Ser Ser Ser Asp Met Glu Lys Arg Leu Arg 
385                 390                 395                 400 


Ala Glu Met Gln Lys Ala Glu Asp Lys Ala Val Glu His Lys Glu Ile 
                405                 410                 415     


Leu Asp Gln Leu Glu Ser Leu Lys Leu Glu Asn Arg His Leu Ser Glu 
            420                 425                 430         


Met Val Met Lys Leu Glu Leu Gly Leu His Glu Cys Ser Leu Pro Val 
        435                 440                 445             


Ser Pro Leu Gly Ser Ile Ala Xaa Arg Phe Leu Glu Glu Glu Glu Leu 
    450                 455                 460                 


Arg Ser His His Ile Leu Glu Arg Leu Asp Ala His Ile Glu Glu Leu 
465                 470                 475                 480 


Lys Arg Glu Ser Glu Lys Xaa Val Arg Gln Phe Xaa Ala Leu Lys 
                485                 490                 495 


<210> 5869
<211> 541
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<400> 5869
Met Glu Ala Leu Leu Glu Gly Ile Gln Asn Arg Gly His Gly Gly Gly 
1               5                   10                  15      


Phe Leu Xaa Ser Cys Glu Ala Glu Leu Gln Glu Leu Met Lys Gln Ile 
            20                  25                  30          


Asp Ile Met Val Ala His Lys Lys Ser Glu Trp Glu Gly Arg Xaa His 
        35                  40                  45              


Ala Leu Glu Xaa Cys Leu Lys Ile Arg Glu Gln Glu Leu Lys Ser Leu 
    50                  55                  60                  


Arg Ser Gln Leu Asp Val Xaa His Lys Glu Val Gly Met Leu His Gln 
65                  70                  75                  80  


Gln Val Glu Glu His Glu Lys Ile Lys Gln Glu Met Xaa Met Glu Tyr 
                85                  90                  95      


Lys Gln Glu Leu Lys Lys Leu His Glu Glu Leu Cys Ile Leu Lys Arg 
            100                 105                 110         


Ser Tyr Glu Lys Leu Gln Lys Lys Gln Met Arg Glu Phe Arg Gly Asn 
        115                 120                 125             


Xaa Lys Asn His Arg Glu Asp Arg Ser Glu Ile Glu Arg Leu Xaa Ala 
    130                 135                 140                 


Lys Ile Glu Glu Phe Arg Gln Lys Ser Leu Asp Trp Glu Lys Gln Arg 
145                 150                 155                 160 


Leu Ile Tyr Gln Gln Gln Val Ser Ser Leu Glu Ala Gln Arg Lys Ala 
                165                 170                 175     


Leu Ala Glu Gln Ser Glu Ile Ile Gln Ala Gln Leu Val Asn Arg Lys 
            180                 185                 190         


Gln Lys Leu Glu Ser Val Glu Leu Ser Ser Gln Ser Glu Ile Gln His 
        195                 200                 205             


Leu Ser Ser Lys Leu Glu Arg Ala Asn Asp Xaa Ile Cys Ala Asn Glu 
    210                 215                 220                 


Leu Glu Ile Glu Arg Leu Xaa Met Arg Val Asn Asp Leu Val Gly Xaa 
225                 230                 235                 240 


Ser Met Xaa Val Leu Gln Glu Gln Gln Gln Lys Glu Glu Lys Leu Arg 
                245                 250                 255     


Glu Ser Glu Lys Leu Leu Glu Ala Leu Gln Glu Glu Lys Arg Glu Leu 
            260                 265                 270         


Lys Ala Ala Leu Gln Ser Gln Glu Asn Leu Ile His Glu Ala Arg Ile 
        275                 280                 285             


Gln Lys Glu Lys Leu Gln Glu Lys Val Lys Ala Xaa Asn Xaa Gln His 
    290                 295                 300                 


Ala Val Glu Ala Ile Arg Pro Arg Glu Glu Ser Leu Ala Glu Lys Lys 
305                 310                 315                 320 


Tyr Xaa Ser Gln Gly Gln Gly Asp Leu Asp Ser Val Leu Ser Gln Leu 
                325                 330                 335     


Asn Phe Xaa His Xaa Ser Glu Asp Leu Leu Gln Ala Glu Val Xaa Cys 
            340                 345                 350         


Leu Glu Gly Ser Leu Glu Ser Val Ser Ala Xaa Cys Lys Gln Leu Ser 
        355                 360                 365             


Gln Glu Leu Met Glu Lys Tyr Glu Glu Leu Lys Arg Met Glu Ala His 
    370                 375                 380                 


Asn Asn Glu Tyr Lys Ala Glu Ile Lys Lys Leu Lys Glu Gln Ile Leu 
385                 390                 395                 400 


Gln Gly Glu Gln Ser Tyr Ser Ser Ala Leu Glu Gly Met Lys Met Glu 
                405                 410                 415     


Ile Ser His Leu Xaa Gln Glu Leu His Gln Arg Asp Ile Xaa Ile Ala 
            420                 425                 430         


Ser Xaa Lys Gly Ser Ser Ser Asp Met Glu Lys Arg Leu Arg Ala Glu 
        435                 440                 445             


Met Gln Lys Ala Glu Asp Lys Ala Val Glu His Lys Glu Ile Leu Asp 
    450                 455                 460                 


Gln Leu Glu Ser Leu Lys Leu Glu Asn Arg His Leu Ser Glu Met Val 
465                 470                 475                 480 


Met Lys Leu Glu Leu Gly Leu His Glu Cys Ser Leu Pro Val Ser Pro 
                485                 490                 495     


Leu Gly Ser Ile Ala Xaa Arg Phe Leu Glu Glu Glu Glu Leu Arg Ser 
            500                 505                 510         


His His Ile Leu Glu Arg Leu Asp Ala His Ile Glu Glu Leu Lys Arg 
        515                 520                 525             


Glu Ser Glu Lys Xaa Val Arg Gln Phe Xaa Ala Leu Lys 
    530                 535                 540     


<210> 5870
<211> 703
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<400> 5870
Met Glu Ala Leu Leu Glu Gly Ile Gln Asn Arg Gly His Gly Gly Gly 
1               5                   10                  15      


Phe Leu Xaa Ser Cys Glu Ala Glu Leu Gln Glu Leu Met Lys Gln Ile 
            20                  25                  30          


Asp Ile Met Val Ala His Lys Lys Ser Glu Trp Glu Gly Arg Xaa His 
        35                  40                  45              


Ala Leu Glu Xaa Cys Leu Lys Ile Arg Glu Gln Glu Leu Lys Ser Leu 
    50                  55                  60                  


Arg Ser Gln Leu Asp Val Xaa His Lys Glu Val Gly Met Leu His Gln 
65                  70                  75                  80  


Gln Val Glu Glu His Glu Lys Ile Lys Gln Glu Met Xaa Met Glu Tyr 
                85                  90                  95      


Lys Gln Glu Leu Lys Lys Leu His Glu Glu Leu Cys Ile Leu Lys Arg 
            100                 105                 110         


Ser Tyr Glu Lys Leu Gln Lys Lys Gln Met Arg Glu Phe Arg Gly Asn 
        115                 120                 125             


Xaa Lys Asn His Arg Glu Asp Arg Ser Glu Ile Glu Arg Leu Xaa Ala 
    130                 135                 140                 


Lys Ile Glu Glu Phe Arg Gln Lys Ser Leu Asp Trp Glu Lys Gln Arg 
145                 150                 155                 160 


Leu Ile Tyr Gln Gln Gln Val Ser Ser Leu Glu Ala Gln Arg Lys Ala 
                165                 170                 175     


Leu Ala Glu Gln Ser Glu Ile Ile Gln Ala Gln Leu Val Asn Arg Lys 
            180                 185                 190         


Gln Lys Leu Glu Ser Val Glu Leu Ser Ser Gln Ser Glu Ile Gln His 
        195                 200                 205             


Leu Ser Ser Lys Leu Glu Arg Ala Asn Asp Xaa Ile Cys Ala Asn Glu 
    210                 215                 220                 


Leu Glu Ile Glu Arg Leu Xaa Met Arg Val Asn Asp Leu Val Gly Xaa 
225                 230                 235                 240 


Ser Met Xaa Val Leu Gln Glu Gln Gln Gln Lys Glu Glu Lys Leu Arg 
                245                 250                 255     


Glu Ser Glu Lys Leu Leu Glu Ala Leu Gln Glu Glu Lys Arg Glu Leu 
            260                 265                 270         


Lys Ala Ala Leu Gln Ser Gln Glu Asn Leu Ile His Glu Ala Arg Ile 
        275                 280                 285             


Gln Lys Glu Lys Leu Gln Glu Lys Val Lys Ala Xaa Asn Xaa Gln His 
    290                 295                 300                 


Ala Val Glu Ala Ile Arg Pro Arg Glu Glu Ser Leu Ala Glu Lys Lys 
305                 310                 315                 320 


Tyr Xaa Ser Gln Gly Gln Gly Asp Leu Asp Ser Val Leu Ser Gln Leu 
                325                 330                 335     


Asn Phe Xaa His Xaa Ser Glu Asp Leu Leu Gln Ala Glu Val Xaa Cys 
            340                 345                 350         


Leu Glu Gly Ser Leu Glu Ser Val Ser Ala Xaa Cys Lys Gln Leu Ser 
        355                 360                 365             


Gln Glu Leu Met Glu Lys Tyr Glu Glu Leu Lys Arg Met Glu Ala His 
    370                 375                 380                 


Asn Asn Glu Tyr Lys Ala Glu Ile Lys Lys Leu Lys Glu Gln Ile Leu 
385                 390                 395                 400 


Gln Gly Glu Gln Ser Tyr Ser Ser Ala Leu Glu Gly Met Lys Met Glu 
                405                 410                 415     


Ile Ser His Leu Xaa Gln Glu Leu His Gln Arg Asp Ile Xaa Ile Ala 
            420                 425                 430         


Ser Xaa Lys Gly Ser Ser Ser Asp Met Glu Lys Arg Leu Arg Ala Glu 
        435                 440                 445             


Met Gln Lys Ala Glu Asp Lys Ala Val Glu His Lys Glu Ile Leu Asp 
    450                 455                 460                 


Gln Leu Glu Ser Leu Lys Leu Glu Asn Arg His Leu Ser Glu Met Val 
465                 470                 475                 480 


Met Lys Leu Glu Leu Gly Leu His Glu Ala Lys Glu Ile Ser Leu Ala 
                485                 490                 495     


Asp Leu Gln Glu Asn Tyr Ile Glu Ala Leu Asn Lys Leu Val Ser Glu 
            500                 505                 510         


Asn Gln Gln Leu Gln Lys Asp Leu Met Asn Xaa Lys Ser Gln Leu Glu 
        515                 520                 525             


Ile Ser Xaa Gln Met Cys Lys Lys Gln Asn Asp Arg Ile Phe Lys Pro 
    530                 535                 540                 


Xaa His Ser Arg Xaa Xaa Glu Phe Lys Asn Xaa Glu Phe Lys Pro Xaa 
545                 550                 555                 560 


His Gly Gln His Arg His Asp Gly Ile Lys Xaa Glu His Tyr Lys Xaa 
                565                 570                 575     


Asp Leu His Ser Pro Arg Gly Gln Ala Ser Asp Ser Ile Asn Pro Met 
            580                 585                 590         


Ser Arg Val Leu Ser Pro Leu Ser Pro Gln Ile Ser Pro Cys Ser Ser 
        595                 600                 605             


Xaa Arg Ser Leu Xaa Ser Tyr Ser Leu Cys Lys Xaa His Ser Leu Pro 
    610                 615                 620                 


Ser Ala Leu Asp Xaa Asn Glu Ala Asn Phe Ser Asp Xaa Met Ser Glu 
625                 630                 635                 640 


Ser Met Asn Asp Gln Glu Glu Phe Ile Ser Ser Cys Ser Leu Pro Val 
                645                 650                 655     


Ser Pro Leu Gly Ser Ile Ala Xaa Arg Phe Leu Glu Glu Glu Glu Leu 
            660                 665                 670         


Arg Ser His His Ile Leu Glu Arg Leu Asp Ala His Ile Glu Glu Leu 
        675                 680                 685             


Lys Arg Glu Ser Glu Lys Xaa Val Arg Gln Phe Xaa Ala Leu Lys 
    690                 695                 700             


<210> 5871
<211> 245
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<400> 5871
Xaa Glu Glu Lys Arg Glu Leu Lys Ala Ala Leu Gln Ser Gln Glu Asn 
1               5                   10                  15      


Leu Ile His Glu Ala Arg Ile Gln Lys Glu Lys Leu Gln Glu Lys Val 
            20                  25                  30          


Lys Ala Xaa Asn Xaa Gln His Ala Val Glu Ala Ile Ser Leu Glu Ser 
        35                  40                  45              


Val Ser Ala Xaa Cys Lys Gln Leu Ser Gln Glu Leu Met Glu Lys Tyr 
    50                  55                  60                  


Glu Glu Leu Lys Arg Met Glu Ala His Asn Asn Glu Tyr Lys Ala Glu 
65                  70                  75                  80  


Ile Lys Lys Leu Lys Glu Gln Ile Leu Gln Gly Glu Gln Ser Tyr Ser 
                85                  90                  95      


Ser Ala Leu Glu Gly Met Lys Met Glu Ile Ser His Leu Xaa Gln Glu 
            100                 105                 110         


Leu His Gln Arg Asp Ile Xaa Ile Ala Ser Xaa Lys Gly Ser Ser Ser 
        115                 120                 125             


Asp Met Glu Lys Arg Leu Arg Ala Glu Met Gln Lys Ala Glu Asp Lys 
    130                 135                 140                 


Ala Val Glu His Lys Glu Ile Leu Asp Gln Leu Glu Ser Leu Lys Leu 
145                 150                 155                 160 


Glu Asn Arg His Leu Ser Glu Met Val Met Lys Leu Glu Leu Gly Leu 
                165                 170                 175     


His Glu Ala Lys Glu Ile Ser Leu Ala Asp Leu Gln Glu Asn Tyr Ile 
            180                 185                 190         


Glu Ala Leu Asn Lys Leu Val Ser Glu Asn Gln Gln Leu Gln Lys Asp 
        195                 200                 205             


Leu Met Asn Xaa Lys Ser Gln Leu Glu Ile Ser Xaa Gln Met Cys Lys 
    210                 215                 220                 


Lys Gln Asn Asp Arg Ile Phe Lys Pro Xaa His Ser Arg Xaa Xaa Glu 
225                 230                 235                 240 


Phe Lys Asn Xaa Glu 
                245 


<210> 5872
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<400> 5872
Xaa Met Leu His Gln Gln Val Glu Glu His Glu Lys Ile Lys Gln Glu 
1               5                   10                  15      


Met Xaa Met Glu Tyr Lys Gln Glu Leu Lys Lys Leu His Glu Glu Leu 
            20                  25                  30          


Cys Ile Leu Lys Arg Ser Tyr Glu Lys Leu Gln Lys Lys Gln Met Arg 
        35                  40                  45              


Glu Phe Arg Gly Asn Xaa Lys Asn His Arg Glu Asp Arg Ser Glu Ile 
    50                  55                  60                  


Glu Arg Leu Xaa Ala Lys Ile Glu Glu Phe Arg Gln Lys Ser Leu Asp 
65                  70                  75                  80  


Trp Glu Lys Gln Arg Leu Ile Tyr Gln Gln Gln Ala Gln Leu Val Asn 
                85                  90                  95      


Arg Lys Gln Lys Leu Glu Ser Val Glu Leu Ser Ser Gln Ser Glu Ile 
            100                 105                 110         


Gln His Leu Ser Ser Lys Leu Glu Arg Ala Asn Asp Xaa Ile Cys Ala 
        115                 120                 125             


Asn Glu Leu Glu Ile Glu Arg Leu Xaa Met Arg Val Asn Asp Leu Val 
    130                 135                 140                 


Gly Xaa Ser Met Xaa Val Leu Gln Glu Gln Gln 
145                 150                 155 


<210> 5873
<211> 267
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<400> 5873
Met His Leu Leu Leu Phe Gln Leu Leu Val Leu Leu Pro Leu Gly Lys 
1               5                   10                  15      


Xaa Xaa Arg His Gln Asp Gly Arg Gln Asn Gln Ser Ser Leu Ser Pro 
            20                  25                  30          


Val Leu Leu Pro Arg Asn Gln Arg Glu Leu Pro Xaa Gly Asn His Glu 
        35                  40                  45              


Glu Ala Glu Glu Lys Pro Asp Leu Phe Val Ala Val Pro His Leu Val 
    50                  55                  60                  


Ala Xaa Ser Pro Ala Gly Glu Gly Gln Arg Gln Arg Glu Lys Met Leu 
65                  70                  75                  80  


Ser Arg Phe Gly Arg Phe Trp Lys Lys Pro Glu Arg Glu Met His Pro 
                85                  90                  95      


Ser Arg Asp Ser Asp Ser Glu Pro Phe Pro Pro Gly Xaa Gln Ser Leu 
            100                 105                 110         


Ile Gln Pro Ile Asp Gly Met Lys Met Glu Lys Ser Pro Leu Arg Glu 
        115                 120                 125             


Glu Ala Lys Lys Phe Trp His His Phe Met Phe Arg Lys Xaa Pro Ala 
    130                 135                 140                 


Ser Gln Gly Val Ile Leu Pro Ile Lys Ser His Glu Val His Trp Glu 
145                 150                 155                 160 


Xaa Cys Arg Xaa Val Pro Phe Ser Gln Xaa Ile Xaa His Glu Gly Cys 
                165                 170                 175     


Glu Lys Val Val Val Gln Asn Asn Leu Cys Phe Gly Lys Cys Gly Ser 
            180                 185                 190         


Val His Phe Pro Gly Ala Ala Gln His Ser His Xaa Ser Cys Ser His 
        195                 200                 205             


Cys Leu Pro Ala Lys Phe Xaa Xaa Met His Leu Pro Leu Asn Cys Xaa 
    210                 215                 220                 


Glu Leu Ser Ser Val Ile Lys Val Val Met Leu Val Glu Glu Cys Gln 
225                 230                 235                 240 


Cys Lys Val Lys Xaa Glu His Glu Asp Gly His Ile Leu His Ala Gly 
                245                 250                 255     


Ser Gln Asp Ser Phe Ile Pro Gly Val Ser Ala 
            260                 265         


<210> 5874
<211> 377
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<400> 5874
Met Leu Gln Xaa Leu Tyr Asp Tyr Phe Trp Trp Glu Arg Leu Trp Leu 
1               5                   10                  15      


Pro Val Asn Leu Xaa Trp Ala Asp Leu Glu Asp Arg Asp Gly Arg Val 
            20                  25                  30          


Tyr Ala Lys Ala Ser Asp Leu Tyr Ile Xaa Leu Pro Leu Ala Leu Leu 
        35                  40                  45              


Phe Leu Ile Val Arg Tyr Phe Phe Glu Leu Tyr Val Ala Xaa Pro Leu 
    50                  55                  60                  


Ala Ala Leu Leu Asn Ile Lys Glu Lys Xaa Arg Leu Arg Ala Pro Pro 
65                  70                  75                  80  


Asn Ala Xaa Leu Glu His Phe Tyr Leu Xaa Ser Gly Lys Gln Pro Lys 
                85                  90                  95      


Gln Ser Gly Leu Ser Gly Arg Gln Val Glu Arg Trp Phe Arg Arg Arg 
            100                 105                 110         


Arg Asn Gln Asp Arg Pro Ser Leu Leu Lys Lys Phe Arg Glu Ala Ser 
        115                 120                 125             


Trp Arg Phe Xaa Phe Tyr Leu Ile Ala Phe Ile Ala Gly Met Ala Val 
    130                 135                 140                 


Ile Val Asp Lys Pro Trp Phe Tyr Asp Met Lys Lys Val Trp Glu Gly 
145                 150                 155                 160 


Tyr Pro Ile Gln Ser Xaa Ile Pro Ser Gln Tyr Trp Tyr Tyr Met Ile 
                165                 170                 175     


Glu Leu Ser Phe Tyr Trp Ser Leu Leu Phe Ser Ile Ala Ser Asp Val 
            180                 185                 190         


Lys Arg Lys Asp Phe Lys Glu Gln Ile Ile His His Val Ala Xaa Ile 
        195                 200                 205             


Ile Leu Ile Ser Phe Ser Trp Phe Ala Asn Tyr Ile Arg Ala Gly Xaa 
    210                 215                 220                 


Leu Ile Met Ala Leu His Asp Ser Ser Asp Tyr Leu Leu Glu Ser Ala 
225                 230                 235                 240 


Lys Met Phe Asn Tyr Ala Gly Trp Lys Asn Xaa Cys Asn Asn Ile Phe 
                245                 250                 255     


Ile Val Phe Ala Ile Val Phe Ile Ile Xaa Arg Leu Val Ile Leu Pro 
            260                 265                 270         


Phe Trp Ile Leu His Cys Xaa Leu Val Tyr Pro Leu Glu Leu Tyr Pro 
        275                 280                 285             


Ala Phe Phe Gly Tyr Tyr Phe Phe Asn Ser Met Met Gly Val Leu Gln 
    290                 295                 300                 


Leu Leu His Ile Phe Trp Ala Tyr Leu Ile Leu Arg Met Ala His Lys 
305                 310                 315                 320 


Phe Ile Xaa Gly Lys Glu Leu Gly Gly Val Ala Ser Pro Glu Xaa Ser 
                325                 330                 335     


Gly Gln Gly Ser Xaa Ile Arg Lys Xaa Gln Phe Leu Arg Lys Arg Gln 
            340                 345                 350         


Phe Lys Lys Gly Trp Glu Glu Gly Cys Pro Leu Lys Lys Xaa Ser Ser 
        355                 360                 365             


Ala Phe Asn Gly Pro Xaa Ala Xaa Glu 
    370                 375         


<210> 5875
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<400> 5875
Met Leu Gln Xaa Leu Tyr Asp Tyr Phe Trp Trp Glu Arg Leu Trp Leu 
1               5                   10                  15      


Pro Val Asn Leu Xaa Trp Ala Asp Leu Glu Asp Arg Asp Gly Arg Val 
            20                  25                  30          


Tyr Ala Lys Ala Ser Asp Leu Tyr Ile Xaa Leu Pro Leu Ala Leu Leu 
        35                  40                  45              


Phe Leu Ile Val Arg Tyr Phe Phe Glu Leu Tyr Val Ala Xaa Pro Leu 
    50                  55                  60                  


Ala Ala Leu Leu Asn Ile Lys Glu Lys Xaa Arg Leu Arg Ala Pro Pro 
65                  70                  75                  80  


Asn Ala Xaa Leu Glu His Phe Tyr Leu Xaa Ser Gly Lys Gln Pro Lys 
                85                  90                  95      


Gln Val Glu Val Glu Leu Leu Ser Arg Gln Ser Gly Leu Ser Gly Arg 
            100                 105                 110         


Gln Val Glu Arg Trp Phe Arg Arg Arg Arg Asn Gln Asp Arg Pro Ser 
        115                 120                 125             


Leu 
    


<210> 5876
<211> 192
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<400> 5876
Met Leu Gln Xaa Leu Tyr Asp Tyr Phe Trp Trp Glu Arg Leu Trp Leu 
1               5                   10                  15      


Pro Val Asn Leu Xaa Trp Ala Asp Leu Glu Asp Arg Asp Gly Arg Val 
            20                  25                  30          


Tyr Ala Lys Ala Ser Asp Leu Tyr Ile Xaa Leu Pro Leu Ala Leu Leu 
        35                  40                  45              


Phe Leu Ile Val Arg Tyr Phe Phe Glu Leu Tyr Val Ala Xaa Pro Leu 
    50                  55                  60                  


Ala Ala Leu Leu Asn Ile Lys Glu Lys Xaa Arg Leu Arg Ala Pro Pro 
65                  70                  75                  80  


Asn Ala Xaa Leu Glu His Phe Tyr Leu Xaa Ser Gly Lys Gln Pro Lys 
                85                  90                  95      


Gln Val Glu Val Glu Leu Leu Ser Arg Gln Ser Gly Leu Ser Gly Arg 
            100                 105                 110         


Gln Val Glu Arg Trp Phe Arg Arg Arg Arg Asn Gln Asp Arg Pro Ser 
        115                 120                 125             


Leu Leu Lys Lys Phe Arg Glu Ala Ser Trp Arg Phe Xaa Phe Tyr Leu 
    130                 135                 140                 


Ile Ala Phe Ile Ala Gly Met Ala Val Ile Val Asp Lys Pro Trp Phe 
145                 150                 155                 160 


Tyr Asp Met Lys Lys Val Trp Glu Gly Tyr Pro Ile Gln Ser Xaa Ile 
                165                 170                 175     


Pro Ser Gln Tyr Trp Tyr Tyr Met Ile Glu Leu Ser Phe Tyr Trp Ser 
            180                 185                 190         


<210> 5877
<211> 223
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<400> 5877
Met Leu Gln Xaa Leu Tyr Asp Tyr Phe Trp Trp Glu Arg Leu Trp Leu 
1               5                   10                  15      


Pro Val Asn Leu Xaa Trp Ala Asp Leu Glu Asp Arg Asp Gly Arg Val 
            20                  25                  30          


Tyr Ala Lys Ala Ser Asp Leu Tyr Ile Xaa Leu Pro Leu Ala Leu Leu 
        35                  40                  45              


Phe Leu Ile Val Arg Tyr Phe Phe Glu Leu Tyr Val Ala Xaa Pro Leu 
    50                  55                  60                  


Ala Ala Leu Leu Asn Ile Lys Glu Lys Xaa Arg Leu Arg Ala Pro Pro 
65                  70                  75                  80  


Asn Ala Xaa Leu Glu His Phe Tyr Leu Xaa Ser Gly Lys Gln Pro Lys 
                85                  90                  95      


Gln Val Glu Val Glu Leu Leu Ser Arg Gln Ser Gly Leu Ser Gly Arg 
            100                 105                 110         


Gln Val Glu Arg Trp Phe Arg Arg Arg Arg Asn Gln Asp Arg Pro Ser 
        115                 120                 125             


Leu Leu Lys Lys Phe Arg Glu Ala Ser Trp Arg Phe Xaa Phe Tyr Leu 
    130                 135                 140                 


Ile Ala Phe Ile Ala Gly Met Ala Val Ile Val Asp Lys Pro Trp Phe 
145                 150                 155                 160 


Tyr Asp Met Lys Lys Val Trp Glu Gly Tyr Pro Ile Gln Ser Xaa Ile 
                165                 170                 175     


Pro Ser Gln Tyr Trp Tyr Tyr Met Ile Glu Leu Ser Phe Tyr Trp Ser 
            180                 185                 190         


Leu Leu Phe Ser Ile Ala Ser Asp Val Lys Arg Lys Asp Phe Lys Glu 
        195                 200                 205             


Gln Ile Ile His His Val Ala Xaa Ile Ile Leu Ile Ser Phe Ser 
    210                 215                 220             


<210> 5878
<211> 304
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<400> 5878
Met Leu Gln Xaa Leu Tyr Asp Tyr Phe Trp Trp Glu Arg Leu Trp Leu 
1               5                   10                  15      


Pro Val Asn Leu Xaa Trp Ala Asp Leu Glu Asp Arg Asp Gly Arg Val 
            20                  25                  30          


Tyr Ala Lys Ala Ser Asp Leu Tyr Ile Xaa Leu Pro Leu Ala Leu Leu 
        35                  40                  45              


Phe Leu Ile Val Arg Tyr Phe Phe Glu Leu Tyr Val Ala Xaa Pro Leu 
    50                  55                  60                  


Ala Ala Leu Leu Asn Ile Lys Glu Lys Xaa Arg Leu Arg Ala Pro Pro 
65                  70                  75                  80  


Asn Ala Xaa Leu Glu His Phe Tyr Leu Xaa Ser Gly Lys Gln Pro Lys 
                85                  90                  95      


Gln Val Glu Val Glu Leu Leu Ser Arg Gln Ser Gly Leu Ser Gly Arg 
            100                 105                 110         


Gln Val Glu Arg Trp Phe Arg Arg Arg Arg Asn Gln Asp Arg Pro Ser 
        115                 120                 125             


Leu Leu Lys Lys Phe Arg Glu Ala Ser Trp Arg Phe Xaa Phe Tyr Leu 
    130                 135                 140                 


Ile Ala Phe Ile Ala Gly Met Ala Val Ile Val Asp Lys Pro Trp Phe 
145                 150                 155                 160 


Tyr Asp Met Lys Lys Val Trp Glu Gly Tyr Pro Ile Gln Ser Xaa Ile 
                165                 170                 175     


Pro Ser Gln Tyr Trp Tyr Tyr Met Ile Glu Leu Ser Phe Tyr Trp Ser 
            180                 185                 190         


Leu Leu Phe Ser Ile Ala Ser Asp Val Lys Arg Lys Asp Phe Lys Glu 
        195                 200                 205             


Gln Ile Ile His His Val Ala Xaa Ile Ile Leu Ile Ser Phe Ser Trp 
    210                 215                 220                 


Phe Ala Asn Tyr Ile Arg Ala Gly Xaa Leu Ile Met Ala Leu His Asp 
225                 230                 235                 240 


Ser Ser Asp Tyr Leu Leu Glu Ser Ala Lys Met Phe Asn Tyr Ala Gly 
                245                 250                 255     


Trp Lys Asn Xaa Cys Asn Asn Ile Phe Ile Val Phe Ala Ile Val Phe 
            260                 265                 270         


Ile Ile Xaa Arg Leu Val Ile Leu Pro Phe Trp Ile Leu His Cys Xaa 
        275                 280                 285             


Leu Val Tyr Pro Leu Glu Leu Tyr Pro Ala Phe Phe Gly Tyr Tyr Phe 
    290                 295                 300                 


<210> 5879
<211> 380
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<400> 5879
Met Leu Gln Xaa Leu Tyr Asp Tyr Phe Trp Trp Glu Arg Leu Trp Leu 
1               5                   10                  15      


Pro Val Asn Leu Xaa Trp Ala Asp Leu Glu Asp Arg Asp Gly Arg Val 
            20                  25                  30          


Tyr Ala Lys Ala Ser Asp Leu Tyr Ile Xaa Leu Pro Leu Ala Leu Leu 
        35                  40                  45              


Phe Leu Ile Val Arg Tyr Phe Phe Glu Leu Tyr Val Ala Xaa Pro Leu 
    50                  55                  60                  


Ala Ala Leu Leu Asn Ile Lys Glu Lys Xaa Arg Leu Arg Ala Pro Pro 
65                  70                  75                  80  


Asn Ala Xaa Leu Glu His Phe Tyr Leu Xaa Ser Gly Lys Gln Pro Lys 
                85                  90                  95      


Gln Val Glu Val Glu Leu Leu Ser Arg Gln Ser Gly Leu Ser Gly Arg 
            100                 105                 110         


Gln Val Glu Arg Trp Phe Arg Arg Arg Arg Asn Gln Asp Arg Pro Ser 
        115                 120                 125             


Leu Leu Lys Lys Phe Arg Glu Ala Ser Trp Arg Phe Xaa Phe Tyr Leu 
    130                 135                 140                 


Ile Ala Phe Ile Ala Gly Met Ala Val Ile Val Asp Lys Pro Trp Phe 
145                 150                 155                 160 


Tyr Asp Met Lys Lys Val Trp Glu Gly Tyr Pro Ile Gln Ser Xaa Ile 
                165                 170                 175     


Pro Ser Gln Tyr Trp Tyr Tyr Met Ile Glu Leu Ser Phe Tyr Trp Ser 
            180                 185                 190         


Leu Leu Phe Ser Ile Ala Ser Asp Val Lys Arg Lys Asp Phe Lys Glu 
        195                 200                 205             


Gln Ile Ile His His Val Ala Xaa Ile Ile Leu Ile Ser Phe Ser Trp 
    210                 215                 220                 


Phe Ala Asn Tyr Ile Arg Ala Gly Xaa Leu Ile Met Ala Leu His Asp 
225                 230                 235                 240 


Ser Ser Asp Tyr Leu Leu Glu Ser Ala Lys Met Phe Asn Tyr Ala Gly 
                245                 250                 255     


Trp Lys Asn Xaa Cys Asn Asn Ile Phe Ile Val Phe Ala Ile Val Phe 
            260                 265                 270         


Ile Ile Xaa Arg Leu Val Ile Leu Pro Phe Trp Ile Leu His Cys Xaa 
        275                 280                 285             


Leu Val Tyr Pro Leu Glu Leu Tyr Pro Ala Phe Phe Gly Tyr Tyr Phe 
    290                 295                 300                 


Phe Asn Ser Met Met Gly Val Leu Gln Leu Leu His Ile Phe Trp Ala 
305                 310                 315                 320 


Tyr Leu Ile Leu Arg Met Ala His Lys Phe Ile Xaa Gly Lys Leu Val 
                325                 330                 335     


Glu Asp Glu Arg Ser Asp Arg Glu Glu Xaa Glu Ser Ser Glu Gly Glu 
            340                 345                 350         


Glu Ala Ala Ala Gly Gly Gly Ala Lys Ser Arg Pro Leu Ala Asn Gly 
        355                 360                 365             


His Pro Ile Leu Asn Asn Asn His Arg Lys Asn Asp 
    370                 375                 380 


<210> 5880
<211> 249
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<400> 5880
Met Leu Gln Xaa Leu Tyr Asp Tyr Phe Trp Trp Glu Arg Leu Trp Leu 
1               5                   10                  15      


Pro Val Asn Leu Xaa Trp Ala Asp Leu Glu Asp Arg Asp Gly Arg Val 
            20                  25                  30          


Tyr Ala Lys Ala Ser Asp Leu Tyr Ile Xaa Leu Pro Leu Ala Leu Leu 
        35                  40                  45              


Phe Leu Ile Val Arg Tyr Phe Phe Glu Leu Tyr Val Ala Xaa Pro Leu 
    50                  55                  60                  


Ala Ala Leu Leu Asn Ile Lys Glu Lys Xaa Arg Leu Arg Ala Pro Pro 
65                  70                  75                  80  


Asn Ala Xaa Leu Glu His Phe Tyr Leu Xaa Ser Gly Lys Gln Pro Lys 
                85                  90                  95      


Gln Val Glu Val Glu Leu Leu Ser Arg Gln Ser Gly Leu Ser Gly Arg 
            100                 105                 110         


Gln Val Glu Arg Trp Phe Arg Arg Arg Arg Asn Gln Asp Arg Pro Ser 
        115                 120                 125             


Leu Leu Lys Lys Phe Arg Glu Ala Ser Trp Arg Phe Xaa Phe Tyr Leu 
    130                 135                 140                 


Ile Ala Phe Ile Ala Gly Met Ala Val Ile Val Asp Lys Pro Trp Phe 
145                 150                 155                 160 


Tyr Asp Met Lys Lys Val Trp Glu Gly Tyr Pro Ile Gln Ser Xaa Ile 
                165                 170                 175     


Pro Ser Gln Tyr Trp Tyr Tyr Met Ile Glu Leu Ser Phe Tyr Trp Ser 
            180                 185                 190         


Leu Leu Phe Ser Ile Ala Ser Asp Val Lys Arg Lys Asp Phe Lys Glu 
        195                 200                 205             


Gln Ile Ile His His Val Ala Xaa Ile Ile Leu Ile Ser Phe Ser Trp 
    210                 215                 220                 


Phe Ala Asn Tyr Ile Arg Ala Gly Xaa Leu Ile Met Ala Leu His Asp 
225                 230                 235                 240 


Ser Ser Asp Tyr Leu Leu Glu Val Arg 
                245                 


<210> 5881
<211> 228
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<400> 5881
Xaa Ser Leu Gln Lys Pro Trp Phe Tyr Asp Met Lys Lys Val Trp Glu 
1               5                   10                  15      


Gly Tyr Pro Ile Gln Ser Xaa Ile Pro Ser Gln Tyr Trp Tyr Tyr Met 
            20                  25                  30          


Ile Glu Leu Ser Phe Tyr Trp Ser Leu Leu Phe Ser Ile Ala Ser Asp 
        35                  40                  45              


Val Lys Arg Lys Asp Phe Lys Glu Gln Ile Ile His His Val Ala Xaa 
    50                  55                  60                  


Ile Ile Leu Ile Ser Phe Ser Trp Phe Ala Asn Tyr Ile Arg Ala Gly 
65                  70                  75                  80  


Xaa Leu Ile Met Ala Leu His Asp Ser Ser Asp Tyr Leu Leu Glu Ser 
                85                  90                  95      


Ala Lys Met Phe Asn Tyr Ala Gly Trp Lys Asn Xaa Cys Asn Asn Ile 
            100                 105                 110         


Phe Ile Val Phe Ala Ile Val Phe Ile Ile Xaa Arg Leu Val Ile Leu 
        115                 120                 125             


Pro Phe Trp Ile Leu His Cys Xaa Leu Val Tyr Pro Leu Glu Leu Tyr 
    130                 135                 140                 


Pro Ala Phe Phe Gly Tyr Tyr Phe Phe Asn Ser Met Met Gly Val Leu 
145                 150                 155                 160 


Gln Leu Leu His Ile Phe Trp Ala Tyr Leu Ile Leu Arg Met Ala His 
                165                 170                 175     


Lys Phe Ile Xaa Gly Lys Leu Val Glu Asp Glu Arg Ser Asp Arg Glu 
            180                 185                 190         


Glu Xaa Glu Ser Ser Glu Gly Glu Glu Ala Ala Ala Gly Gly Gly Ala 
        195                 200                 205             


Lys Ser Arg Pro Leu Ala Asn Gly His Pro Ile Leu Asn Asn Asn His 
    210                 215                 220                 


Arg Lys Asn Asp 
225             


<210> 5882
<211> 15
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<400> 5882
Met Phe Trp Xaa Phe Lys Glu Trp Phe Trp Leu Glu Arg Phe Trp 
1               5                   10                  15  


<210> 5883
<211> 162
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<400> 5883
Met Phe Trp Xaa Phe Lys Glu Trp Phe Trp Leu Glu Arg Phe Trp Leu 
1               5                   10                  15      


Pro Pro Xaa Ile Lys Trp Ser Asp Leu Glu Asp His Asp Gly Leu Val 
            20                  25                  30          


Phe Val Lys Pro Ser His Leu Tyr Val Xaa Ile Pro Tyr Ala Phe Leu 
        35                  40                  45              


Leu Leu Ile Ile Arg Arg Val Phe Glu Lys Phe Val Ala Ser Pro Leu 
    50                  55                  60                  


Ala Lys Ser Phe Gly Ile Lys Glu Xaa Val Arg Lys Val Xaa Pro Asn 
65                  70                  75                  80  


Xaa Val Leu Glu Asn Phe Phe Lys His Ser Xaa Arg Gln Pro Leu Gln 
                85                  90                  95      


Xaa Asp Ile Tyr Gly Leu Ala Lys Lys Cys Asn Leu Xaa Glu Arg Gln 
            100                 105                 110         


Val Glu Arg Trp Phe Arg Ser Arg Arg Asn Gln Glu Arg Pro Ser Arg 
        115                 120                 125             


Leu Lys Lys Phe Gln Glu Ala Cys Trp Arg Phe Ala Phe Tyr Leu Met 
    130                 135                 140                 


Ile Xaa Val Ala Gly Ile Ala Phe Leu Tyr Asp Lys Pro Trp Leu Tyr 
145                 150                 155                 160 


Asp Leu 
        


<210> 5884
<211> 383
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<400> 5884
Met Phe Trp Xaa Phe Lys Glu Trp Phe Trp Leu Glu Arg Phe Trp Leu 
1               5                   10                  15      


Pro Pro Xaa Ile Lys Trp Ser Asp Leu Glu Asp His Asp Gly Leu Val 
            20                  25                  30          


Phe Val Lys Pro Ser His Leu Tyr Val Xaa Ile Pro Tyr Ala Phe Leu 
        35                  40                  45              


Leu Leu Ile Ile Arg Arg Val Phe Glu Lys Phe Val Ala Ser Pro Leu 
    50                  55                  60                  


Ala Lys Ser Phe Gly Ile Lys Glu Xaa Val Arg Lys Val Xaa Pro Asn 
65                  70                  75                  80  


Xaa Val Leu Glu Asn Phe Phe Lys His Ser Xaa Arg Gln Pro Leu Gln 
                85                  90                  95      


Xaa Asp Ile Tyr Gly Leu Ala Lys Lys Cys Asn Leu Xaa Glu Arg Gln 
            100                 105                 110         


Val Glu Arg Trp Phe Arg Ser Arg Arg Asn Gln Glu Arg Pro Ser Arg 
        115                 120                 125             


Leu Lys Lys Phe Gln Glu Ala Cys Trp Arg Phe Ala Phe Tyr Leu Met 
    130                 135                 140                 


Ile Xaa Val Ala Gly Ile Ala Phe Leu Tyr Asp Lys Pro Trp Leu Tyr 
145                 150                 155                 160 


Asp Leu Trp Glu Val Trp Asn Gly Tyr Pro Lys Gln Pro Leu Leu Pro 
                165                 170                 175     


Ser Gln Tyr Trp Tyr Tyr Ile Leu Glu Met Ser Phe Tyr Trp Ser Leu 
            180                 185                 190         


Leu Phe Arg Leu Gly Phe Asp Val Lys Arg Lys Asp Phe Leu Ala His 
        195                 200                 205             


Ile Ile His His Leu Ala Ala Ile Ser Leu Met Ser Phe Ser Trp Cys 
    210                 215                 220                 


Ala Asn Tyr Ile Arg Ser Gly Xaa Leu Val Met Ile Val His Asp Val 
225                 230                 235                 240 


Ala Asp Ile Trp Leu Glu Ser Ala Lys Met Phe Ser Tyr Ala Gly Trp 
                245                 250                 255     


Xaa Gln Xaa Cys Asn Xaa Leu Phe Phe Ile Phe Ser Xaa Ile Phe Phe 
            260                 265                 270         


Ile Ser Arg Leu Ile Val Phe Pro Phe Trp Ile Leu Tyr Cys Xaa Leu 
        275                 280                 285             


Ile Leu Pro Met Tyr His Leu Glu Pro Phe Phe Ser Tyr Ile Phe Leu 
    290                 295                 300                 


Asn Leu Gln Leu Met Ile Leu Gln Val Leu His Leu Tyr Trp Gly Tyr 
305                 310                 315                 320 


Tyr Ile Leu Lys Met Leu Asn Arg Cys Ile Phe Met Lys Ser Ile Gln 
                325                 330                 335     


Asp Val Arg Ser Asp Asp Glu Asp Tyr Glu Glu Glu Glu Glu Glu Glu 
            340                 345                 350         


Glu Glu Glu Ala Xaa Lys Gly Lys Glu Met Asp Cys Leu Lys Asn Gly 
        355                 360                 365             


Leu Arg Ala Glu Arg His Leu Ile Pro Asn Gly Gln His Gly His 
    370                 375                 380             


<210> 5885
<211> 32
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<400> 5885
Met Leu Ser Ser Phe Asn Glu Trp Phe Trp Gln Asp Arg Phe Trp Leu 
1               5                   10                  15      


Pro Pro Asn Val Xaa Trp Xaa Glu Leu Glu Asp Arg Asp Gly Arg Val 
            20                  25                  30          


<210> 5886
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<400> 5886
Met Leu Ser Ser Phe Asn Glu Trp Phe Trp Gln Asp Arg Phe Trp Leu 
1               5                   10                  15      


Pro Pro Asn Val Xaa Trp Xaa Glu Leu Glu Asp Arg Asp Gly Arg Val 
            20                  25                  30          


Tyr Pro His Pro Gln Asp Leu Leu Ala Ala Leu Pro Leu Ala Leu Val 
        35                  40                  45              


Leu Leu Ala Met Arg Leu Ala Phe Glu Arg Phe Ile Gly Leu Pro Leu 
    50                  55                  60                  


Ser Arg Trp Leu Gly Val Arg Asp Gln Xaa Arg Arg Gln Val Lys Pro 
65                  70                  75                  80  


Asn Ala Xaa Leu Glu Lys His Phe Leu Xaa Glu Gly 
                85                  90          


<210> 5887
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 5887
Met Leu Ser Ser Phe Asn Glu Trp Phe Trp Gln Asp Arg Phe Trp Leu 
1               5                   10                  15      


Pro Pro Asn Val Xaa Trp Xaa Glu Leu Glu Asp Arg Asp Gly Arg Val 
            20                  25                  30          


Tyr Pro His Pro Gln Asp Leu Leu Ala Ala Leu Pro Leu Ala Leu Val 
        35                  40                  45              


Leu Leu Ala Met Arg Leu Ala Phe Glu Arg Phe Ile Gly Leu Pro Leu 
    50                  55                  60                  


Ser Arg Trp Leu Gly Val Arg Asp Gln Xaa Arg Arg Gln Val Lys Pro 
65                  70                  75                  80  


Asn Ala Xaa Leu Glu Lys His Phe Leu Xaa Glu Gly His Arg Pro Lys 
                85                  90                  95      


Glu Pro Gln Leu Ser Leu Leu Ala Ala Gln Cys Gly Leu Xaa Leu Gln 
            100                 105                 110         


Gln 
    


<210> 5888
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 5888
Met Leu Ser Ser Phe Asn Glu Trp Phe Trp Gln Asp Arg Phe Trp Leu 
1               5                   10                  15      


Pro Pro Asn Val Xaa Trp Xaa Glu Leu Glu Asp Arg Asp Gly Arg Val 
            20                  25                  30          


Tyr Pro His Pro Gln Asp Leu Leu Ala Ala Leu Pro Leu Ala Leu Val 
        35                  40                  45              


Leu Leu Ala Met Arg Leu Ala Phe Glu Arg Phe Ile Gly Leu Pro Leu 
    50                  55                  60                  


Ser Arg Trp Leu Gly Val Arg Asp Gln Xaa Arg Arg Gln Val Lys Pro 
65                  70                  75                  80  


Asn Ala Xaa Leu Glu Lys His Phe Leu Xaa Glu Gly His Arg Pro Lys 
                85                  90                  95      


Glu Pro Gln Leu Ser Leu Leu Ala Ala Gln Cys Gly Leu Xaa Leu Gln 
            100                 105                 110         


Gln Xaa Gln Arg Trp Phe Arg Arg Arg Arg Asn Gln Asp Arg Pro Gln 
        115                 120                 125             


Leu Xaa Lys Lys Phe Cys Glu Ala 
    130                 135     


<210> 5889
<211> 192
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<400> 5889
Met Leu Ser Ser Phe Asn Glu Trp Phe Trp Gln Asp Arg Phe Trp Leu 
1               5                   10                  15      


Pro Pro Asn Val Xaa Trp Xaa Glu Leu Glu Asp Arg Asp Gly Arg Val 
            20                  25                  30          


Tyr Pro His Pro Gln Asp Leu Leu Ala Ala Leu Pro Leu Ala Leu Val 
        35                  40                  45              


Leu Leu Ala Met Arg Leu Ala Phe Glu Arg Phe Ile Gly Leu Pro Leu 
    50                  55                  60                  


Ser Arg Trp Leu Gly Val Arg Asp Gln Xaa Arg Arg Gln Val Lys Pro 
65                  70                  75                  80  


Asn Ala Xaa Leu Glu Lys His Phe Leu Xaa Glu Gly His Arg Pro Lys 
                85                  90                  95      


Glu Pro Gln Leu Ser Leu Leu Ala Ala Gln Cys Gly Leu Xaa Leu Gln 
            100                 105                 110         


Gln Xaa Gln Arg Trp Phe Arg Arg Arg Arg Asn Gln Asp Arg Pro Gln 
        115                 120                 125             


Leu Xaa Lys Lys Phe Cys Glu Ala Ser Trp Arg Phe Leu Phe Tyr Leu 
    130                 135                 140                 


Ser Ser Phe Val Gly Gly Leu Ser Val Leu Tyr His Glu Ser Trp Leu 
145                 150                 155                 160 


Trp Ala Pro Val Met Cys Trp Asp Arg Tyr Pro Asn Gln Xaa Leu Lys 
                165                 170                 175     


Pro Ser Leu Tyr Trp Trp Tyr Leu Leu Glu Leu Gly Phe Tyr Leu Ser 
            180                 185                 190         


<210> 5890
<211> 394
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<400> 5890
Met Leu Ser Ser Phe Asn Glu Trp Phe Trp Gln Asp Arg Phe Trp Leu 
1               5                   10                  15      


Pro Pro Asn Val Xaa Trp Xaa Glu Leu Glu Asp Arg Asp Gly Arg Val 
            20                  25                  30          


Tyr Pro His Pro Gln Asp Leu Leu Ala Ala Leu Pro Leu Ala Leu Val 
        35                  40                  45              


Leu Leu Ala Met Arg Leu Ala Phe Glu Arg Phe Ile Gly Leu Pro Leu 
    50                  55                  60                  


Ser Arg Trp Leu Gly Val Arg Asp Gln Xaa Arg Arg Gln Val Lys Pro 
65                  70                  75                  80  


Asn Ala Xaa Leu Glu Lys His Phe Leu Xaa Glu Gly His Arg Pro Lys 
                85                  90                  95      


Glu Pro Gln Leu Ser Leu Leu Ala Ala Gln Cys Gly Leu Xaa Leu Gln 
            100                 105                 110         


Gln Xaa Gln Arg Trp Phe Arg Arg Arg Arg Asn Gln Asp Arg Pro Gln 
        115                 120                 125             


Leu Xaa Lys Lys Phe Cys Glu Ala Ser Trp Arg Phe Leu Phe Tyr Leu 
    130                 135                 140                 


Ser Ser Phe Val Gly Gly Leu Ser Val Leu Tyr His Glu Ser Trp Leu 
145                 150                 155                 160 


Trp Ala Pro Val Met Cys Trp Asp Arg Tyr Pro Asn Gln Xaa Leu Lys 
                165                 170                 175     


Pro Ser Leu Tyr Trp Trp Tyr Leu Leu Glu Leu Gly Phe Tyr Leu Ser 
            180                 185                 190         


Leu Leu Ile Arg Leu Pro Phe Asp Val Lys Arg Lys Asp Phe Lys Glu 
        195                 200                 205             


Gln Val Ile His His Phe Val Ala Val Ile Leu Met Xaa Phe Ser Tyr 
    210                 215                 220                 


Ser Ala Asn Leu Leu Arg Ile Gly Ser Leu Val Leu Leu Leu His Asp 
225                 230                 235                 240 


Ser Ser Asp Tyr Leu Leu Glu Ala Cys Lys Met Val Asn Tyr Met Gln 
                245                 250                 255     


Tyr Gln Gln Val Cys Asp Ala Leu Phe Leu Ile Phe Ser Phe Val Phe 
            260                 265                 270         


Phe Tyr Xaa Arg Leu Val Leu Phe Pro Xaa Gln Ile Leu Tyr Xaa Xaa 
        275                 280                 285             


Tyr Tyr Glu Ser Ile Ser Asn Arg Gly Pro Phe Phe Gly Tyr Tyr Phe 
    290                 295                 300                 


Phe Asn Gly Leu Leu Met Leu Leu Gln Leu Leu His Val Phe Trp Ser 
305                 310                 315                 320 


Cys Leu Ile Leu Arg Met Leu Tyr Ser Phe Met Lys Lys Gly Gln Met 
                325                 330                 335     


Glu Lys Asp Ile Arg Ser Asp Val Glu Glu Ser Asp Ser Ser Glu Glu 
            340                 345                 350         


Ala Ala Ala Ala Gln Glu Pro Leu Gln Leu Lys Asn Gly Ala Ala Gly 
        355                 360                 365             


Gly Pro Arg Pro Ala Pro Xaa Asp Gly Pro Arg Ser Arg Val Ala Gly 
    370                 375                 380                 


Arg Leu Xaa Asn Arg His Xaa Xaa Ala Xaa 
385                 390                 


<210> 5891
<211> 306
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<400> 5891
Met Leu Ser Ser Phe Asn Glu Trp Phe Trp Gln Asp Arg Phe Trp Leu 
1               5                   10                  15      


Pro Pro Asn Val Xaa Trp Xaa Glu Leu Glu Asp Arg Asp Gly Arg Val 
            20                  25                  30          


Tyr Pro His Pro Gln Asp Leu Leu Ala Ala Leu Pro Leu Ala Leu Val 
        35                  40                  45              


Leu Leu Ala Met Arg Leu Ala Phe Glu Arg Phe Ile Gly Leu Pro Leu 
    50                  55                  60                  


Ser Arg Trp Leu Gly Val Arg Asp Gln Xaa Arg Arg Gln Val Lys Pro 
65                  70                  75                  80  


Asn Ala Xaa Leu Glu Lys His Phe Leu Xaa Glu Gly His Arg Pro Lys 
                85                  90                  95      


Glu Pro Gln Leu Ser Leu Leu Ala Ala Gln Cys Gly Leu Xaa Leu Gln 
            100                 105                 110         


Gln Xaa Gln Arg Trp Phe Arg Arg Arg Arg Asn Gln Asp Arg Pro Gln 
        115                 120                 125             


Leu Xaa Lys Lys Phe Cys Glu Ala Ser Trp Arg Phe Leu Phe Tyr Leu 
    130                 135                 140                 


Ser Ser Phe Val Gly Gly Leu Ser Val Leu Tyr His Glu Ser Trp Leu 
145                 150                 155                 160 


Trp Ala Pro Val Met Cys Trp Asp Arg Tyr Pro Asn Gln Xaa Leu Lys 
                165                 170                 175     


Pro Ser Leu Tyr Trp Trp Tyr Leu Leu Glu Leu Gly Phe Tyr Leu Ser 
            180                 185                 190         


Leu Leu Ile Arg Leu Pro Phe Asp Val Lys Arg Lys Asp Phe Lys Glu 
        195                 200                 205             


Gln Val Ile His His Phe Val Ala Val Ile Leu Met Xaa Phe Ser Tyr 
    210                 215                 220                 


Ser Ala Asn Leu Leu Arg Ile Gly Ser Leu Val Leu Leu Leu His Asp 
225                 230                 235                 240 


Ser Ser Asp Tyr Leu Leu Glu Met Glu Lys Asp Ile Arg Ser Asp Val 
                245                 250                 255     


Glu Glu Ser Asp Ser Ser Glu Glu Ala Ala Ala Ala Gln Glu Pro Leu 
            260                 265                 270         


Gln Leu Lys Asn Gly Ala Ala Gly Gly Pro Arg Pro Ala Pro Xaa Asp 
        275                 280                 285             


Gly Pro Arg Ser Arg Val Ala Gly Arg Leu Xaa Asn Arg His Xaa Xaa 
    290                 295                 300                 


Ala Xaa 
305     


<210> 5892
<211> 343
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<400> 5892
Met Arg Leu Ala Phe Glu Arg Phe Ile Gly Leu Pro Leu Ser Arg Trp 
1               5                   10                  15      


Leu Gly Val Arg Asp Gln Xaa Arg Arg Gln Val Lys Pro Asn Ala Xaa 
            20                  25                  30          


Leu Glu Lys His Phe Leu Xaa Glu Gly His Arg Pro Lys Glu Pro Gln 
        35                  40                  45              


Leu Ser Leu Leu Ala Ala Gln Cys Gly Leu Xaa Leu Gln Gln Xaa Gln 
    50                  55                  60                  


Arg Trp Phe Arg Arg Arg Arg Asn Gln Asp Arg Pro Gln Leu Xaa Lys 
65                  70                  75                  80  


Lys Phe Cys Glu Ala Ser Trp Arg Phe Leu Phe Tyr Leu Ser Ser Phe 
                85                  90                  95      


Val Gly Gly Leu Ser Val Leu Tyr His Glu Ser Trp Leu Trp Ala Pro 
            100                 105                 110         


Val Met Cys Trp Asp Arg Tyr Pro Asn Gln Xaa Leu Lys Pro Ser Leu 
        115                 120                 125             


Tyr Trp Trp Tyr Leu Leu Glu Leu Gly Phe Tyr Leu Ser Leu Leu Ile 
    130                 135                 140                 


Arg Leu Pro Phe Asp Val Lys Arg Lys Asp Phe Lys Glu Gln Val Ile 
145                 150                 155                 160 


His His Phe Val Ala Val Ile Leu Met Xaa Phe Ser Tyr Ser Ala Asn 
                165                 170                 175     


Leu Leu Arg Ile Gly Ser Leu Val Leu Leu Leu His Asp Ser Ser Asp 
            180                 185                 190         


Tyr Leu Leu Glu Ala Cys Lys Met Val Asn Tyr Met Gln Tyr Gln Gln 
        195                 200                 205             


Val Cys Asp Ala Leu Phe Leu Ile Phe Ser Phe Val Phe Phe Tyr Xaa 
    210                 215                 220                 


Arg Leu Val Leu Phe Pro Xaa Gln Ile Leu Tyr Xaa Xaa Tyr Tyr Glu 
225                 230                 235                 240 


Ser Ile Ser Asn Arg Gly Pro Phe Phe Gly Tyr Tyr Phe Phe Asn Gly 
                245                 250                 255     


Leu Leu Met Leu Leu Gln Leu Leu His Val Phe Trp Ser Cys Leu Ile 
            260                 265                 270         


Leu Arg Met Leu Tyr Ser Phe Met Lys Lys Gly Gln Met Glu Lys Asp 
        275                 280                 285             


Ile Arg Ser Asp Val Glu Glu Ser Asp Ser Ser Glu Glu Ala Ala Ala 
    290                 295                 300                 


Ala Gln Glu Pro Leu Gln Leu Lys Asn Gly Ala Ala Gly Gly Pro Arg 
305                 310                 315                 320 


Pro Ala Pro Xaa Asp Gly Pro Arg Ser Arg Val Ala Gly Arg Leu Xaa 
                325                 330                 335     


Asn Arg His Xaa Xaa Ala Xaa 
            340             


<210> 5893
<211> 66
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<400> 5893
Met Ala Xaa Ala Ala Gln Gly Pro Leu Ser Leu Leu Trp Gly Trp Leu 
1               5                   10                  15      


Trp Ser Glu Arg Phe Trp Leu Pro Glu Asn Val Ser Trp Ala Asp Leu 
            20                  25                  30          


Glu Gly Pro Ala Asp Gly Tyr Gly Tyr Pro Arg Gly Arg His Ile Leu 
        35                  40                  45              


Ser Val Phe Pro Leu Ala Ala Gly Ile Phe Phe Val Arg Leu Leu Phe 
    50                  55                  60                  


Glu Arg 
65      


<210> 5894
<211> 195
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<400> 5894
Met Ala Xaa Ala Ala Gln Gly Pro Leu Ser Leu Leu Trp Gly Trp Leu 
1               5                   10                  15      


Trp Ser Glu Arg Phe Trp Leu Pro Glu Asn Val Ser Trp Ala Asp Leu 
            20                  25                  30          


Glu Gly Pro Ala Asp Gly Tyr Gly Tyr Pro Arg Gly Arg His Ile Leu 
        35                  40                  45              


Ser Val Phe Pro Leu Ala Ala Gly Ile Phe Phe Val Arg Leu Leu Phe 
    50                  55                  60                  


Glu Arg Phe Ile Ala Lys Pro Cys Ala Leu Cys Ile Gly Ile Glu Asp 
65                  70                  75                  80  


Ser Gly Pro Tyr Gln Ala Gln Pro Asn Ala Ile Leu Glu Lys Val Phe 
                85                  90                  95      


Ile Ser Ile Xaa Lys Tyr Pro Asp Lys Lys Arg Leu Glu Gly Leu Ser 
            100                 105                 110         


Lys Gln Leu Asp Trp Asn Val Arg Lys Ile Gln Cys Trp Phe Arg His 
        115                 120                 125             


Arg Arg Asn Gln Asp Lys Pro Pro Xaa Leu Xaa Lys Phe Cys Glu Ser 
    130                 135                 140                 


Ile His Leu Gly Ser Gly Xaa Ser Asp Ser Ala Gly Ile Xaa Ile His 
145                 150                 155                 160 


Phe Ser Leu Phe Gln Val Gly Phe Ile Xaa Ile Ile Ser Trp Asn Trp 
                165                 170                 175     


Pro Ser Ile Gly Pro Leu Cys Phe Leu Ser Leu Gln Xaa Leu Lys Glu 
            180                 185                 190         


Arg Xaa Ser 
        195 


<210> 5895
<211> 259
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<400> 5895
Met Ala Xaa Ala Ala Gln Gly Pro Leu Ser Leu Leu Trp Gly Trp Leu 
1               5                   10                  15      


Trp Ser Glu Arg Phe Trp Leu Pro Glu Asn Val Ser Trp Ala Asp Leu 
            20                  25                  30          


Glu Gly Pro Ala Asp Gly Tyr Gly Tyr Pro Arg Gly Arg His Ile Leu 
        35                  40                  45              


Ser Val Phe Pro Leu Ala Ala Gly Ile Phe Phe Val Arg Leu Leu Phe 
    50                  55                  60                  


Glu Arg Phe Ile Ala Lys Pro Cys Ala Leu Cys Ile Gly Ile Glu Asp 
65                  70                  75                  80  


Ser Gly Pro Tyr Gln Ala Gln Pro Asn Ala Ile Leu Glu Lys Val Phe 
                85                  90                  95      


Ile Ser Ile Xaa Lys Tyr Pro Asp Lys Lys Arg Leu Glu Gly Leu Ser 
            100                 105                 110         


Lys Gln Leu Asp Trp Asn Val Arg Lys Ile Gln Cys Trp Phe Arg His 
        115                 120                 125             


Arg Arg Asn Gln Asp Lys Pro Pro Xaa Leu Xaa Lys Phe Cys Glu Ser 
    130                 135                 140                 


Met Trp Arg Phe Xaa Phe Tyr Leu Cys Ile Phe Cys Tyr Gly Ile Arg 
145                 150                 155                 160 


Phe Leu Trp Ser Ser Pro Trp Phe Trp Asp Ile Arg Gln Cys Trp His 
                165                 170                 175     


Asn Tyr Pro Phe Gln Asp Phe Leu Ile Met Phe Val His His Leu Val 
            180                 185                 190         


Xaa Ile Gly Leu Ile Ser Phe Ser Tyr Ile Asn Asn Met Val Arg Val 
        195                 200                 205             


Gly Xaa Leu Ile Met Cys Leu His Asp Val Ser Asp Phe Leu Leu Glu 
    210                 215                 220                 


Ala Ala Lys Leu Ala Asn Tyr Ala Lys Tyr Gln Arg Leu Cys Asp Xaa 
225                 230                 235                 240 


Leu Phe Val Ile Phe Ser Ala Val Phe Met Val Xaa Arg Leu Gly Ile 
                245                 250                 255     


Tyr Pro Phe 
            


<210> 5896
<211> 351
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<400> 5896
Met Ala Xaa Ala Ala Gln Gly Pro Leu Ser Leu Leu Trp Gly Trp Leu 
1               5                   10                  15      


Trp Ser Glu Arg Phe Trp Leu Pro Glu Asn Val Ser Trp Ala Asp Leu 
            20                  25                  30          


Glu Gly Pro Ala Asp Gly Tyr Gly Tyr Pro Arg Gly Arg His Ile Leu 
        35                  40                  45              


Ser Val Phe Pro Leu Ala Ala Gly Ile Phe Phe Val Arg Leu Leu Phe 
    50                  55                  60                  


Glu Arg Phe Ile Ala Lys Pro Cys Ala Leu Cys Ile Gly Ile Glu Asp 
65                  70                  75                  80  


Ser Gly Pro Tyr Gln Ala Gln Pro Asn Ala Ile Leu Glu Lys Val Phe 
                85                  90                  95      


Ile Ser Ile Xaa Lys Tyr Pro Asp Lys Lys Arg Leu Glu Gly Leu Ser 
            100                 105                 110         


Lys Gln Leu Asp Trp Asn Val Arg Lys Ile Gln Cys Trp Phe Arg His 
        115                 120                 125             


Arg Arg Asn Gln Asp Lys Pro Pro Xaa Leu Xaa Lys Phe Cys Glu Ser 
    130                 135                 140                 


Met Trp Arg Phe Xaa Phe Tyr Leu Cys Ile Phe Cys Tyr Gly Ile Arg 
145                 150                 155                 160 


Phe Leu Trp Ser Ser Pro Trp Phe Trp Asp Ile Arg Gln Cys Trp His 
                165                 170                 175     


Asn Tyr Pro Phe Gln Pro Leu Ser Ser Gly Leu Tyr His Tyr Tyr Ile 
            180                 185                 190         


Met Glu Leu Ala Phe Tyr Trp Ser Leu Met Phe Ser Gln Phe Xaa Asp 
        195                 200                 205             


Ile Lys Arg Lys Asp Phe Leu Ile Met Phe Val His His Leu Val Xaa 
    210                 215                 220                 


Ile Gly Leu Ile Ser Phe Ser Tyr Ile Asn Asn Met Val Arg Val Gly 
225                 230                 235                 240 


Xaa Leu Ile Met Cys Leu His Asp Val Ser Asp Phe Leu Leu Glu Ala 
                245                 250                 255     


Ala Lys Leu Ala Asn Tyr Ala Lys Tyr Gln Arg Leu Cys Asp Xaa Leu 
            260                 265                 270         


Phe Val Ile Phe Ser Ala Val Phe Met Val Xaa Arg Leu Gly Ile Tyr 
        275                 280                 285             


Pro Phe Cys Phe Ser Val Leu Phe Tyr Ser Xaa Phe Ala Asn Arg Xaa 
    290                 295                 300                 


Gln Glu Pro Tyr Cys Pro Ala Phe Xaa Leu Ala Cys Ala Asp Leu Leu 
305                 310                 315                 320 


Trp Xaa Leu Ile Gly Pro Leu Leu Pro Gln Xaa Val Phe Leu Ala Arg 
                325                 330                 335     


Ser Asp Pro Asp Ser Glu Tyr Pro Ala Trp Leu Ala Ser Gln Asp 
            340                 345                 350     


<210> 5897
<211> 392
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<400> 5897
Met Ala Xaa Ala Ala Gln Gly Pro Leu Ser Leu Leu Trp Gly Trp Leu 
1               5                   10                  15      


Trp Ser Glu Arg Phe Trp Leu Pro Glu Asn Val Ser Trp Ala Asp Leu 
            20                  25                  30          


Glu Gly Pro Ala Asp Gly Tyr Gly Tyr Pro Arg Gly Arg His Ile Leu 
        35                  40                  45              


Ser Val Phe Pro Leu Ala Ala Gly Ile Phe Phe Val Arg Leu Leu Phe 
    50                  55                  60                  


Glu Arg Phe Ile Ala Lys Pro Cys Ala Leu Cys Ile Gly Ile Glu Asp 
65                  70                  75                  80  


Ser Gly Pro Tyr Gln Ala Gln Pro Asn Ala Ile Leu Glu Lys Val Phe 
                85                  90                  95      


Ile Ser Ile Xaa Lys Tyr Pro Asp Lys Lys Arg Leu Glu Gly Leu Ser 
            100                 105                 110         


Lys Gln Leu Asp Trp Asn Val Arg Lys Ile Gln Cys Trp Phe Arg His 
        115                 120                 125             


Arg Arg Asn Gln Asp Lys Pro Pro Xaa Leu Xaa Lys Phe Cys Glu Ser 
    130                 135                 140                 


Met Trp Arg Phe Xaa Phe Tyr Leu Cys Ile Phe Cys Tyr Gly Ile Arg 
145                 150                 155                 160 


Phe Leu Trp Ser Ser Pro Trp Phe Trp Asp Ile Arg Gln Cys Trp His 
                165                 170                 175     


Asn Tyr Pro Phe Gln Pro Leu Ser Ser Gly Leu Tyr His Tyr Tyr Ile 
            180                 185                 190         


Met Glu Leu Ala Phe Tyr Trp Ser Leu Met Phe Ser Gln Phe Xaa Asp 
        195                 200                 205             


Ile Lys Arg Lys Asp Phe Leu Ile Met Phe Val His His Leu Val Xaa 
    210                 215                 220                 


Ile Gly Leu Ile Ser Phe Ser Tyr Ile Asn Asn Met Val Arg Val Gly 
225                 230                 235                 240 


Xaa Leu Ile Met Cys Leu His Asp Val Ser Asp Phe Leu Leu Glu Ala 
                245                 250                 255     


Ala Lys Leu Ala Asn Tyr Ala Lys Tyr Gln Arg Leu Cys Asp Xaa Leu 
            260                 265                 270         


Phe Val Ile Phe Ser Ala Val Phe Met Val Xaa Arg Leu Gly Ile Tyr 
        275                 280                 285             


Pro Phe Trp Ile Leu Asn Xaa Xaa Leu Phe Glu Ser Trp Glu Ile Ile 
    290                 295                 300                 


Gly Pro Tyr Ala Ser Trp Trp Leu Leu Asn Gly Leu Leu Leu Xaa Leu 
305                 310                 315                 320 


Gln Leu Leu His Val Ile Trp Ser Tyr Leu Ile Ala Arg Ile Ala Leu 
                325                 330                 335     


Lys Ala Leu Ile Arg Gly Lys Val Ser Lys Asp Asp Arg Ser Asp Val 
            340                 345                 350         


Glu Ser Ser Ser Glu Glu Glu Asp Val Xaa Xaa Cys Xaa Lys Ser Pro 
        355                 360                 365             


Cys Asp Ser Ser Ser Ser Asn Gly Ala Asn Arg Val Asn Gly His Met 
    370                 375                 380                 


Gly Gly Ser Tyr Trp Ala Glu Glu 
385                 390         


<210> 5898
<211> 179
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<400> 5898
Met Ala Xaa Ala Ala Gln Gly Pro Leu Ser Leu Leu Trp Gly Trp Leu 
1               5                   10                  15      


Trp Ser Glu Arg Phe Trp Leu Pro Glu Asn Val Ser Trp Ala Asp Leu 
            20                  25                  30          


Glu Gly Pro Ala Asp Gly Tyr Gly Tyr Pro Arg Gly Arg His Ile Leu 
        35                  40                  45              


Ser Val Phe Pro Leu Ala Ala Gly Ile Phe Phe Val Arg Leu Leu Phe 
    50                  55                  60                  


Glu Arg Ile Leu Ile Arg Lys Gly Trp Arg Ala Cys Gln Ser Ser Trp 
65                  70                  75                  80  


Ile Gly Met Ser Glu Lys Ser Asn Ala Gly Phe Ala Ile Gly Gly Ile 
                85                  90                  95      


Arg Xaa Ser Pro Gln Arg Leu Leu Asn Ser Val Lys Ala Cys Gly Asp 
            100                 105                 110         


Ser His Phe Ile Tyr Val Tyr Ser Ala Met Glu Leu Asp Phe Ser Gly 
        115                 120                 125             


Arg His Leu Gly Ser Gly Xaa Ser Asp Ser Ala Gly Ile Xaa Ile His 
    130                 135                 140                 


Phe Ser Leu Phe Gln Val Gly Phe Ile Xaa Ile Ile Ser Trp Asn Trp 
145                 150                 155                 160 


Pro Ser Ile Gly Pro Leu Cys Phe Leu Ser Leu Gln Xaa Leu Lys Glu 
                165                 170                 175     


Arg Xaa Ser 
            


<210> 5899
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<400> 5899
Met Ala Xaa Ala Ala Gln Gly Pro Leu Ser Leu Leu Trp Gly Trp Leu 
1               5                   10                  15      


Trp Ser Glu Arg Phe Trp Leu Pro Glu Asn Val Ser Trp Ala Asp Leu 
            20                  25                  30          


Glu Gly Pro Ala Asp Gly Tyr Gly Tyr Pro Arg Gly Arg His Ile Leu 
        35                  40                  45              


Ser Val Phe Pro Leu Ala Ala Gly Ile Phe Phe Val Arg Leu Leu Phe 
    50                  55                  60                  


Glu Arg Leu Glu Cys Ser Gly Ala Ile Ser Leu Gln Pro Ser Xaa Pro 
65                  70                  75                  80  


Trp Phe Lys Arg Phe Ser Cys Leu Ser Leu Pro Ser Ser 
                85                  90              


<210> 5900
<211> 73
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<400> 5900
Met Ala Xaa Ala Ala Gln Gly Pro Leu Ser Leu Leu Trp Gly Trp Leu 
1               5                   10                  15      


Trp Ser Glu Arg Phe Trp Leu Pro Glu Asn Val Ser Trp Ala Asp Leu 
            20                  25                  30          


Glu Gly Pro Ala Asp Gly Tyr Gly Tyr Pro Arg Gly Arg His Ile Leu 
        35                  40                  45              


Ser Val Phe Pro Leu Ala Ala Gly Ile Phe Phe Val Arg Leu Leu Phe 
    50                  55                  60                  


Glu Arg Arg Asp Gly Val Ser Leu Cys 
65                  70              


<210> 5901
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<400> 5901
Met Ala Xaa Ala Ala Gln Gly Pro Leu Ser Leu Leu Trp Gly Trp Leu 
1               5                   10                  15      


Trp Ser Glu Arg Phe Trp Leu Pro Glu Asn Val Ser Trp Ala Asp Leu 
            20                  25                  30          


Glu Gly Pro Ala Asp Gly Tyr Gly Tyr Pro Arg Gly Arg His Ile Leu 
        35                  40                  45              


Ser Val Phe Pro Leu Ala Ala Gly Ile Phe Phe Val Arg Leu Leu Phe 
    50                  55                  60                  


Glu Arg Val Cys Phe Val Ala Gln Xaa Gly Val Gln Trp 
65                  70                  75          


<210> 5902
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<400> 5902
Met Ala Xaa Ala Ala Gln Gly Pro Leu Ser Leu Leu Trp Gly Trp Leu 
1               5                   10                  15      


Trp Ser Glu Arg Phe Trp Leu Pro Glu Asn Val Ser Trp Ala Asp Leu 
            20                  25                  30          


Glu Gly Pro Ala Asp Gly Tyr Gly Tyr Pro Arg Gly Arg His Ile Leu 
        35                  40                  45              


Ser Val Phe Pro Leu Ala Ala Gly Ile Phe Phe Val Arg Leu Leu Phe 
    50                  55                  60                  


Glu Arg Val Gln Ala Ile Leu Leu Pro Gln Pro Pro Lys 
65                  70                  75          


<210> 5903
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<400> 5903
Met Ala Xaa Ala Ala Gln Gly Pro Leu Ser Leu Leu Trp Gly Trp Leu 
1               5                   10                  15      


Trp Ser Glu Arg Phe Trp Leu Pro Glu Asn Val Ser Trp Ala Asp Leu 
            20                  25                  30          


Glu Gly Pro Ala Asp Gly Tyr Gly Tyr Pro Arg Gly Arg His Ile Leu 
        35                  40                  45              


Ser Val Phe Pro Leu Ala Ala Gly Ile Phe Phe Val Arg Leu Leu Phe 
    50                  55                  60                  


Glu Arg Trp Cys Phe Ala Leu Val Ala Gln Ala Gly Val Gln Trp Cys 
65                  70                  75                  80  


Ser His Ser Ser Leu Gln Pro Leu Pro Pro Arg Phe Lys 
                85                  90              


<210> 5904
<211> 334
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<400> 5904
Met Met Lys Pro Arg Pro Lys Arg Phe Ile Ala Lys Pro Cys Ala Leu 
1               5                   10                  15      


Cys Ile Gly Ile Glu Asp Ser Gly Pro Tyr Gln Ala Gln Pro Asn Ala 
            20                  25                  30          


Ile Leu Glu Lys Val Phe Ile Ser Ile Xaa Lys Tyr Pro Asp Lys Lys 
        35                  40                  45              


Arg Leu Glu Gly Leu Ser Lys Gln Leu Asp Trp Asn Val Arg Lys Ile 
    50                  55                  60                  


Gln Cys Trp Phe Arg His Arg Arg Asn Gln Asp Lys Pro Pro Xaa Leu 
65                  70                  75                  80  


Xaa Lys Phe Cys Glu Ser Met Trp Arg Phe Xaa Phe Tyr Leu Cys Ile 
                85                  90                  95      


Phe Cys Tyr Gly Ile Arg Phe Leu Trp Ser Ser Pro Trp Phe Trp Asp 
            100                 105                 110         


Ile Arg Gln Cys Trp His Asn Tyr Pro Phe Gln Pro Leu Ser Ser Gly 
        115                 120                 125             


Leu Tyr His Tyr Tyr Ile Met Glu Leu Ala Phe Tyr Trp Ser Leu Met 
    130                 135                 140                 


Phe Ser Gln Phe Xaa Asp Ile Lys Arg Lys Asp Phe Leu Ile Met Phe 
145                 150                 155                 160 


Val His His Leu Val Xaa Ile Gly Leu Ile Ser Phe Ser Tyr Ile Asn 
                165                 170                 175     


Asn Met Val Arg Val Gly Xaa Leu Ile Met Cys Leu His Asp Val Ser 
            180                 185                 190         


Asp Phe Leu Leu Glu Ala Ala Lys Leu Ala Asn Tyr Ala Lys Tyr Gln 
        195                 200                 205             


Arg Leu Cys Asp Xaa Leu Phe Val Ile Phe Ser Ala Val Phe Met Val 
    210                 215                 220                 


Xaa Arg Leu Gly Ile Tyr Pro Phe Trp Ile Leu Asn Xaa Xaa Leu Phe 
225                 230                 235                 240 


Glu Ser Trp Glu Ile Ile Gly Pro Tyr Ala Ser Trp Trp Leu Leu Asn 
                245                 250                 255     


Gly Leu Leu Leu Xaa Leu Gln Leu Leu His Val Ile Trp Ser Tyr Leu 
            260                 265                 270         


Ile Ala Arg Ile Ala Leu Lys Ala Leu Ile Arg Gly Lys Val Ser Lys 
        275                 280                 285             


Asp Asp Arg Ser Asp Val Glu Ser Ser Ser Glu Glu Glu Asp Val Xaa 
    290                 295                 300                 


Xaa Cys Xaa Lys Ser Pro Cys Asp Ser Ser Ser Ser Asn Gly Ala Asn 
305                 310                 315                 320 


Arg Val Asn Gly His Met Gly Gly Ser Tyr Trp Ala Glu Glu 
                325                 330                 


<210> 5905
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<400> 5905
Xaa Leu Cys Ile Phe Cys Tyr Gly Ile Arg Phe Leu Trp Ser Asp Phe 
1               5                   10                  15      


Leu Ile Met Phe Val His His Leu Val Xaa Ile Gly Leu Ile Ser Phe 
            20                  25                  30          


Ser Tyr Ile Asn Asn Met Val Arg Val Gly Xaa Leu Ile Met Cys Leu 
        35                  40                  45              


His Asp Val Ser Asp Phe Leu Leu Glu Ala Ala Lys Leu Ala Asn Tyr 
    50                  55                  60                  


Ala Lys Tyr Gln Arg Leu Cys Asp Xaa Leu Phe Val Ile Phe Ser Ala 
65                  70                  75                  80  


Val Phe Met Val Xaa Arg Leu Gly Ile Tyr Pro Phe Trp Ile Leu Asn 
                85                  90                  95      


Xaa Xaa Leu Phe Glu Ser Trp Glu Ile Ile Gly Pro Tyr Ala Ser Trp 
            100                 105                 110         


Trp Leu Leu Asn Gly Leu Leu Leu Xaa Leu Gln Leu Leu His Val Ile 
        115                 120                 125             


Trp Ser Tyr Leu Ile Ala Arg Ile 
    130                 135     


<210> 5906
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<400> 5906
Xaa Leu Phe Val Ile Phe Ser Ala Val Phe Met Val Xaa Arg Leu Gly 
1               5                   10                  15      


Ile Tyr Pro Phe Trp Ile Leu Asn Xaa Xaa Leu Phe Glu Ser Trp Glu 
            20                  25                  30          


Ile Ile Gly Pro Tyr Ala Ser Trp Trp Leu Leu Asn Gly Leu Leu Leu 
        35                  40                  45              


Xaa Leu Gln Leu Leu His Val Ile Trp Ser Tyr Leu Ile Ala Arg Ile 
    50                  55                  60                  


Ala Leu Lys Ala Leu Ile Arg Gly Lys Val Xaa Cys Pro Gly Arg Ile 
65                  70                  75                  80  


Arg Pro Cys Xaa Leu His Ser Phe Leu Xaa Ser Phe Leu Phe Ser Met 
                85                  90                  95      


Pro Gly Gly Ser Trp Xaa Val Ser Ser Leu Ala Cys Ile Glu Gly 
            100                 105                 110     


<210> 5907
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 5907
Xaa Tyr Ile Asn Asn Met Val Arg Val Gly Xaa Leu Ile Met Cys Leu 
1               5                   10                  15      


His Asp Val Ser Asp Phe Leu Leu Glu Ala Ala Lys Leu Ala Asn Tyr 
            20                  25                  30          


Ala Lys Tyr Gln Arg Leu Cys Asp Xaa Leu Phe Val Ile Phe Ser Ala 
        35                  40                  45              


Val Phe Met Val Xaa Arg Leu Gly Ile Tyr Pro Phe Trp Tyr Arg Arg 
    50                  55                  60                  


Met Ile Ala Val Met Trp Arg Ala Ala Gln Arg Lys Lys Met 
65                  70                  75              


<210> 5908
<211> 384
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<400> 5908
Met Ala Gly Ile Leu Ala Trp Phe Trp Asn Glu Arg Phe Trp Leu Pro 
1               5                   10                  15      


His Asn Val Xaa Trp Ala Asp Leu Lys Asn Xaa Glu Glu Ala Xaa Phe 
            20                  25                  30          


Pro Gln Ala Glu Asp Leu Tyr Leu Ala Phe Pro Leu Ala Phe Cys Ile 
        35                  40                  45              


Phe Met Val Arg Leu Ile Phe Glu Arg Phe Val Ala Lys Pro Cys Ala 
    50                  55                  60                  


Ile Ala Leu Asn Ile Gln Ala Asn Gly Pro Gln Ile Ala Pro Pro Asn 
65                  70                  75                  80  


Ala Ile Leu Glu Lys Val Phe Xaa Ala Ile Xaa Lys His Pro Asp Glu 
                85                  90                  95      


Lys Arg Leu Glu Gly Leu Ser Lys Gln Leu Asp Trp Asp Val Arg Ser 
            100                 105                 110         


Ile Gln Arg Trp Phe Arg Gln Arg Arg Asn Gln Glu Lys Pro Ser Xaa 
        115                 120                 125             


Leu Xaa Arg Phe Cys Glu Ser Met Trp Arg Phe Ser Phe Tyr Leu Tyr 
    130                 135                 140                 


Val Phe Xaa Tyr Gly Val Arg Phe Leu Lys Lys Xaa Pro Trp Leu Trp 
145                 150                 155                 160 


Asn Xaa Arg His Cys Trp Tyr Asn Tyr Pro Tyr Gln Pro Leu Xaa Xaa 
                165                 170                 175     


Asp Leu His Tyr Tyr Tyr Ile Leu Glu Leu Ser Phe Tyr Trp Ser Leu 
            180                 185                 190         


Met Phe Ser Gln Phe Xaa Asp Ile Lys Arg Lys Asp Phe Gly Ile Met 
        195                 200                 205             


Phe Leu His His Leu Val Ser Ile Phe Leu Ile Xaa Phe Ser Tyr Val 
    210                 215                 220                 


Asn Asn Met Ala Arg Val Gly Xaa Leu Val Leu Cys Leu His Asp Ser 
225                 230                 235                 240 


Ala Asp Ala Leu Leu Glu Ala Ala Lys Met Ala Asn Tyr Ala Lys Phe 
                245                 250                 255     


Gln Lys Met Cys Asp Leu Leu Phe Val Met Phe Ala Val Val Phe Ile 
            260                 265                 270         


Xaa Xaa Arg Leu Gly Ile Phe Pro Leu Trp Val Leu Asn Xaa Xaa Leu 
        275                 280                 285             


Phe Glu Ser Trp Glu Ile Val Gly Pro Tyr Pro Ser Trp Trp Val Phe 
    290                 295                 300                 


Asn Leu Leu Leu Leu Leu Val Gln Gly Leu Asn Cys Phe Trp Ser Tyr 
305                 310                 315                 320 


Leu Ile Val Lys Ile Ala Cys Lys Ala Val Ser Arg Gly Lys Val Ser 
                325                 330                 335     


Lys Asp Asp Arg Ser Asp Ile Glu Ser Ser Ser Asp Glu Glu Asp Ser 
            340                 345                 350         


Glu Pro Pro Gly Lys Asn Pro His Xaa Ala Xaa Xaa Xaa Asn Gly Xaa 
        355                 360                 365             


Ser Gly Xaa Asn Gly Tyr Leu Leu Xaa Gly Ser Cys Ser Met Asp Asp 
    370                 375                 380                 


<210> 5909
<211> 392
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<400> 5909
Met Ala Gly Ile Leu Ala Trp Phe Trp Asn Glu Arg Phe Trp Leu Pro 
1               5                   10                  15      


His Asn Val Xaa Trp Ala Asp Leu Lys Asn Xaa Glu Glu Ala Xaa Phe 
            20                  25                  30          


Pro Gln Ala Glu Asp Leu Tyr Leu Ala Phe Pro Leu Ala Phe Cys Ile 
        35                  40                  45              


Phe Met Val Arg Leu Ile Phe Glu Arg Phe Val Ala Lys Pro Cys Ala 
    50                  55                  60                  


Ile Ala Leu Asn Ile Gln Ala Asn Gly Pro Gln Ile Ala Pro Pro Asn 
65                  70                  75                  80  


Ala Ile Leu Glu Lys Val Phe Xaa Ala Ile Xaa Lys His Pro Asp Glu 
                85                  90                  95      


Lys Arg Leu Glu Gly Leu Ser Lys Gln Leu Asp Trp Asp Val Arg Ser 
            100                 105                 110         


Ile Gln Arg Trp Phe Arg Gln Arg Arg Asn Gln Glu Lys Pro Ser Xaa 
        115                 120                 125             


Leu Xaa Arg Phe Cys Glu Ser Met Trp Arg Phe Ser Phe Tyr Leu Tyr 
    130                 135                 140                 


Val Phe Xaa Tyr Gly Val Arg Phe Leu Lys Lys Xaa Pro Trp Leu Trp 
145                 150                 155                 160 


Asn Xaa Arg His Cys Trp Tyr Asn Tyr Pro Tyr Gln Pro Leu Xaa Xaa 
                165                 170                 175     


Asp Leu His Tyr Tyr Tyr Ile Leu Glu Leu Ser Phe Tyr Trp Ser Leu 
            180                 185                 190         


Met Phe Ser Gln Phe Xaa Asp Ile Lys Arg Lys Asp Phe Gly Ile Met 
        195                 200                 205             


Phe Leu His His Leu Val Ser Ile Phe Leu Ile Xaa Phe Ser Tyr Val 
    210                 215                 220                 


Asn Asn Met Ala Arg Val Gly Xaa Leu Val Leu Cys Leu His Asp Ser 
225                 230                 235                 240 


Ala Asp Ala Leu Leu Glu Ala Ala Lys Met Ala Asn Tyr Ala Lys Phe 
                245                 250                 255     


Gln Lys Met Cys Asp Leu Leu Phe Val Met Phe Ala Val Val Phe Ile 
            260                 265                 270         


Xaa Xaa Arg Leu Gly Ile Phe Pro Leu Trp Val Leu Asn Xaa Xaa Leu 
        275                 280                 285             


Phe Glu Ser Trp Glu Ile Val Gly Pro Tyr Pro Ser Trp Trp Val Phe 
    290                 295                 300                 


Asn Leu Leu Leu Leu Leu Val Gln Gly Leu Asn Cys Phe Trp Ser Tyr 
305                 310                 315                 320 


Leu Ile Val Lys Ile Ala Cys Lys Ala Val Ser Arg Gly Lys Ala Gly 
                325                 330                 335     


Lys Trp Asn Pro Leu His Val Ser Lys Asp Asp Arg Ser Asp Ile Glu 
            340                 345                 350         


Ser Ser Ser Asp Glu Glu Asp Ser Glu Pro Pro Gly Lys Asn Pro His 
        355                 360                 365             


Xaa Ala Xaa Xaa Xaa Asn Gly Xaa Ser Gly Xaa Asn Gly Tyr Leu Leu 
    370                 375                 380                 


Xaa Gly Ser Cys Ser Met Asp Asp 
385                 390         


<210> 5910
<211> 148
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<400> 5910
Met Xaa Trp Arg His His Val Arg Leu Leu Phe Xaa Val Ser Leu Ala 
1               5                   10                  15      


Leu Gln Ile Ile Asn Leu Gly Asn Ser Tyr Gln Arg Glu Lys His Asn 
            20                  25                  30          


Gly Gly Arg Glu Glu Val Xaa Lys Val Ala Xaa Gln Lys His Arg Gln 
        35                  40                  45              


Ser Pro Leu Asn Trp Xaa Ser Ser His Phe Gly Glu Val Xaa Gly Ser 
    50                  55                  60                  


Ala Glu Gly Trp Gly Pro Glu Glu Pro Leu Pro Tyr Ser Arg Ala Phe 
65                  70                  75                  80  


Gly Glu Asp Pro Lys Asp Phe Leu Ala Ser His Ala His Gly Pro Ser 
                85                  90                  95      


Ala Gly Gly Ala Pro Ser Leu Leu Leu Leu Leu Pro Cys Ala Leu Leu 
            100                 105                 110         


His Arg Leu Leu Arg Pro Asp Ala Pro Ala His Pro Arg Ser Leu Val 
        115                 120                 125             


Pro Ser Val Leu Gln Arg Glu Arg Arg Pro Cys Gly Arg Pro Gly Leu 
    130                 135                 140                 


Gly His Arg Leu 
145             


<210> 5911
<211> 223
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<400> 5911
Met Xaa Trp Arg His His Val Arg Leu Leu Phe Xaa Val Ser Leu Ala 
1               5                   10                  15      


Leu Gln Ile Ile Asn Leu Gly Asn Ser Tyr Gln Arg Glu Lys His Asn 
            20                  25                  30          


Gly Gly Arg Glu Glu Val Xaa Lys Val Ala Xaa Gln Lys His Arg Gln 
        35                  40                  45              


Ser Pro Leu Asn Trp Xaa Ser Ser His Phe Gly Glu Val Xaa Gly Ser 
    50                  55                  60                  


Ala Glu Gly Trp Gly Pro Glu Glu Pro Leu Pro Tyr Ser Arg Ala Phe 
65                  70                  75                  80  


Gly Glu Gly Ala Ser Ala Arg Pro Arg Cys Cys Arg Asn Gly Gly Xaa 
                85                  90                  95      


Cys Val Leu Gly Ser Phe Cys Val Cys Pro Ala His Phe Xaa Gly Arg 
            100                 105                 110         


Tyr Cys Glu His Asp Gln Arg Arg Ser Glu Cys Gly Ala Leu Glu His 
        115                 120                 125             


Gly Ala Trp Xaa Leu Arg Ala Cys His Leu Cys Arg Cys Ile Phe Gly 
    130                 135                 140                 


Ala Leu His Cys Leu Pro Leu Gln Xaa Pro Asp Arg Cys Asp Pro Lys 
145                 150                 155                 160 


Asp Phe Leu Ala Ser His Ala His Gly Pro Ser Ala Gly Gly Ala Pro 
                165                 170                 175     


Ser Leu Leu Leu Leu Leu Pro Cys Ala Leu Leu His Arg Leu Leu Arg 
            180                 185                 190         


Pro Asp Ala Pro Ala His Pro Arg Ser Leu Val Pro Ser Val Leu Gln 
        195                 200                 205             


Arg Glu Arg Arg Pro Cys Gly Arg Pro Gly Leu Gly His Arg Leu 
    210                 215                 220             


<210> 5912
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<400> 5912
Met Xaa Trp Arg His His Val Arg Leu Leu Phe Xaa Val Ser Leu Ala 
1               5                   10                  15      


Leu Gln Ile Ile Asn Leu Gly Asn Ser Tyr Gln Arg Glu Lys His Asn 
            20                  25                  30          


Gly Gly Arg Glu Glu Val Xaa Lys Val Ala Xaa Gln Lys His Arg Gln 
        35                  40                  45              


Ser Pro Leu Asn Trp Xaa Ser Ser His Phe Gly Glu Val Xaa Gly Ser 
    50                  55                  60                  


Ala Glu Gly Trp Gly Pro Glu Glu Pro Leu Pro Tyr Ser Arg Ala Phe 
65                  70                  75                  80  


Gly Glu Val Asn Ala Ala Pro Trp Ser Xaa Glu Pro Gly Pro Ser Ala 
                85                  90                  95      


Pro Ala Xaa Ser Ala Gly Ala Ser Ser Gly Pro Cys Xaa Ala Ser Pro 
            100                 105                 110         


Ser Arg Arg Leu Xaa Ala Val Xaa Arg Lys Xaa Ser Trp Pro Pro Xaa 
        115                 120                 125             


Leu Xaa Gly Arg Ala Pro Gly Ala Arg Pro Ala Cys Tyr Ser Cys Cys 
    130                 135                 140                 


Pro Ala His Ser Cys Xaa Ala Ser Cys Ala Arg Met Arg Pro Arg Xaa 
145                 150                 155                 160 


Leu Gly Pro Trp Ser Leu Pro Ser Ser Ser Gly Ser Gly Ala Pro Ala 
                165                 170                 175     


Glu Gly Arg Asp Leu Gly Ile Ala Phe Asn Phe Leu Cys Cys Lys 
            180                 185                 190     


<210> 5913
<211> 91
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<400> 5913
Met Ala Ser Gly Val Ala Val Ser Asp Gly Val Ile Lys Val Phe Asn 
1               5                   10                  15      


Asp Met Lys Val Arg Lys Ser Ser Xaa Pro Glu Glu Val Lys Lys Arg 
            20                  25                  30          


Lys Lys Ala Val Leu Phe Cys Leu Ser Glu Asp Lys Lys Asn Ile Ile 
        35                  40                  45              


Leu Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Gln Xaa Val 
    50                  55                  60                  


Asp Asp Pro Tyr Ala Xaa Phe Val Lys Met Leu Pro Asp Lys Asp Cys 
65                  70                  75                  80  


Arg Tyr Ala Leu Tyr Asp Ala Xaa Tyr Glu Xaa 
                85                  90      


<210> 5914
<211> 160
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 5914
Met Ala Ser Gly Val Ala Val Ser Asp Gly Val Ile Lys Val Phe Asn 
1               5                   10                  15      


Asp Met Lys Val Arg Lys Ser Ser Xaa Pro Glu Glu Val Lys Lys Arg 
            20                  25                  30          


Lys Lys Ala Val Leu Phe Cys Leu Ser Glu Asp Lys Lys Asn Ile Ile 
        35                  40                  45              


Leu Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Gln Xaa Val 
    50                  55                  60                  


Asp Asp Pro Tyr Ala Xaa Phe Val Lys Met Leu Pro Asp Lys Asp Cys 
65                  70                  75                  80  


Arg Tyr Ala Leu Tyr Asp Ala Xaa Tyr Glu Xaa Lys Glu Ser Lys Lys 
                85                  90                  95      


Glu Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys 
            100                 105                 110         


Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Leu 
        115                 120                 125             


Xaa Gly Ile Lys His Glu Leu Gln Ala Asn Cys Tyr Glu Glu Val Lys 
    130                 135                 140                 


Asp Arg Cys Xaa Leu Ala Glu Lys Leu Gly Gly Ser Ala Val Ile Ser 
145                 150                 155                 160 


<210> 5915
<211> 166
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 5915
Met Ala Ser Gly Val Ala Val Ser Asp Gly Val Ile Lys Val Phe Asn 
1               5                   10                  15      


Asp Met Lys Val Arg Lys Ser Ser Xaa Pro Glu Glu Val Lys Lys Arg 
            20                  25                  30          


Lys Lys Ala Val Leu Phe Cys Leu Ser Glu Asp Lys Lys Asn Ile Ile 
        35                  40                  45              


Leu Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Gln Xaa Val 
    50                  55                  60                  


Asp Asp Pro Tyr Ala Xaa Phe Val Lys Met Leu Pro Asp Lys Asp Cys 
65                  70                  75                  80  


Arg Tyr Ala Leu Tyr Asp Ala Xaa Tyr Glu Xaa Lys Glu Ser Lys Lys 
                85                  90                  95      


Glu Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys 
            100                 105                 110         


Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Leu 
        115                 120                 125             


Xaa Gly Ile Lys His Glu Leu Gln Ala Asn Cys Tyr Glu Glu Val Lys 
    130                 135                 140                 


Asp Arg Cys Xaa Leu Ala Glu Lys Leu Gly Gly Ser Ala Val Ile Ser 
145                 150                 155                 160 


Leu Glu Gly Lys Pro Leu 
                165     


<210> 5916
<211> 79
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<400> 5916
Met Lys Val Arg Lys Ser Ser Xaa Pro Glu Glu Val Lys Lys Arg Lys 
1               5                   10                  15      


Lys Ala Val Leu Phe Cys Leu Ser Glu Asp Lys Lys Asn Ile Ile Leu 
            20                  25                  30          


Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Gln Xaa Val Asp 
        35                  40                  45              


Asp Pro Tyr Ala Xaa Phe Val Lys Met Leu Pro Asp Lys Asp Cys Arg 
    50                  55                  60                  


Tyr Ala Leu Tyr Asp Ala Xaa Tyr Glu Xaa Lys Glu Ser Lys Lys 
65                  70                  75                  


<210> 5917
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<400> 5917
Met Lys Val Arg Lys Ser Ser Xaa Pro Glu Glu Val Lys Lys Arg Lys 
1               5                   10                  15      


Lys Ala Val Leu Phe Cys Leu Ser Glu Asp Lys Lys Asn Ile Ile Leu 
            20                  25                  30          


Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Gln Xaa Val Asp 
        35                  40                  45              


Asp Pro Tyr Ala Xaa Phe Val Lys Met Leu Pro Asp Lys Asp Cys Arg 
    50                  55                  60                  


Tyr Ala Leu Tyr Asp Ala Xaa Tyr Glu Xaa Lys Glu Ser Lys Lys Glu 
65                  70                  75                  80  


Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys Ser 
                85                  90                  95      


Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Leu Xaa 
            100                 105                 110         


Gly Ile Lys His Glu Leu Gln Ala Asn Cys 
        115                 120         


<210> 5918
<211> 149
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<400> 5918
Met Lys Val Arg Lys Ser Ser Xaa Pro Glu Glu Val Lys Lys Arg Lys 
1               5                   10                  15      


Lys Ala Val Leu Phe Cys Leu Ser Glu Asp Lys Lys Asn Ile Ile Leu 
            20                  25                  30          


Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Gln Xaa Val Asp 
        35                  40                  45              


Asp Pro Tyr Ala Xaa Phe Val Lys Met Leu Pro Asp Lys Asp Cys Arg 
    50                  55                  60                  


Tyr Ala Leu Tyr Asp Ala Xaa Tyr Glu Xaa Lys Glu Ser Lys Lys Glu 
65                  70                  75                  80  


Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys Ser 
                85                  90                  95      


Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Leu Xaa 
            100                 105                 110         


Gly Ile Lys His Glu Leu Gln Ala Asn Cys Tyr Glu Glu Val Lys Asp 
        115                 120                 125             


Arg Cys Xaa Leu Ala Glu Lys Leu Gly Gly Ser Ala Val Ile Ser Leu 
    130                 135                 140                 


Glu Gly Lys Pro Leu 
145                 


<210> 5919
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<400> 5919
Met Val Ser Pro Gly His Gly His Leu Arg Glu Arg Lys Glu Leu Xaa 
1               5                   10                  15      


Pro His Ser Xaa Asn Pro Ala Ala Ala Arg Ile Trp Asp Ala Xaa Tyr 
            20                  25                  30          


Ser Asp Gly Tyr Val Arg Pro Ala Ser Gly Val Ala Val Ser Asp Gly 
        35                  40                  45              


Val Ile Lys Val Phe Asn Asp Met Lys Val Arg Lys Ser Ser Xaa Pro 
    50                  55                  60                  


Glu Glu Val Lys Lys Arg Lys Lys Ala Val Leu Phe Cys Leu Ser Glu 
65                  70                  75                  80  


Asp Lys Lys Asn Ile Ile Leu Glu Glu Gly Lys Glu Ile Leu Val Gly 
                85                  90                  95      


Asp Val Gly Gln Xaa Val Asp Asp Pro Tyr Ala Xaa Phe Val Lys Met 
            100                 105                 110         


Leu Pro Asp Lys Asp Cys Arg Tyr Ala Leu Tyr Asp Ala Xaa Tyr Glu 
        115                 120                 125             


Xaa Lys Glu Ser Lys Lys Glu Asp Leu Val Phe Ile Phe Trp Ala Pro 
    130                 135                 140                 


Glu Ser Ala Pro Leu Lys Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp 
145                 150                 155                 160 


Ala Ile Lys Lys Lys Leu Xaa Gly Ile Lys His Glu Leu Gln Ala Asn 
                165                 170                 175     


Cys Tyr Glu Glu Val Lys Asp Arg Cys Xaa Leu Ala Glu Lys Leu Gly 
            180                 185                 190         


Gly Ser Ala Val Ile Ser Leu Glu Gly Lys Pro Leu 
        195                 200                 


<210> 5920
<211> 321
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<400> 5920
Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
1               5                   10                  15      


Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 
            20                  25                  30          


Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 
        35                  40                  45              


Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 
    50                  55                  60                  


Arg Ile Asp Leu Lys Xaa Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 
65                  70                  75                  80  


Gly Ala Gly Xaa Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 
                85                  90                  95      


Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Glu Glu Pro Val Lys Lys 
            100                 105                 110         


Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro Glu Glu 
        115                 120                 125             


Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile Ile Asp 
    130                 135                 140                 


Cys Ile Gly Asn Glu Xaa Glu Leu Leu Arg Asp Xaa Phe Xaa Ser Leu 
145                 150                 155                 160 


Gly Tyr Glu Val Gln Lys Phe Leu His Leu Ser Met His Gly Ile Ser 
                165                 170                 175     


Gln Ile Leu Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp Tyr Asp 
            180                 185                 190         


Ser Phe Val Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser Val Tyr 
        195                 200                 205             


Gly Val Asp Gln Xaa His Ser Gly Leu Pro Leu His His Ile Arg Arg 
    210                 215                 220                 


Met Phe Met Gly Asp Ser Cys Pro Tyr Leu Ala Gly Lys Pro Lys Met 
225                 230                 235                 240 


Phe Phe Ile Gln Asn Tyr Val Val Ser Glu Gly Gln Leu Glu Asp Ser 
                245                 250                 255     


Ser Leu Leu Glu Val Asp Gly Pro Ala Met Lys Asn Val Glu Phe Lys 
            260                 265                 270         


Ala Gln Lys Arg Gly Leu Cys Xaa Val His Arg Glu Ala Asp Phe Phe 
        275                 280                 285             


Trp Ser Leu Cys Xaa Ala Asp Met Ser Leu Leu Glu Gln Ser His Ser 
    290                 295                 300                 


Ser Pro Ser Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg Gln Glu 
305                 310                 315                 320 


Arg 
    


<210> 5921
<211> 168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<400> 5921
Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
1               5                   10                  15      


Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 
            20                  25                  30          


Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 
        35                  40                  45              


Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 
    50                  55                  60                  


Arg Ile Asp Leu Lys Xaa Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 
65                  70                  75                  80  


Gly Ala Gly Xaa Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 
                85                  90                  95      


Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Leu His Asn Gly Arg Ser 
            100                 105                 110         


Lys Glu Gln Arg Leu Lys Glu Gln Leu Gly Ala Gln Gln Glu Pro Val 
        115                 120                 125             


Lys Lys Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro 
    130                 135                 140                 


Glu Glu Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile 
145                 150                 155                 160 


Ile Asp Cys Ile Gly Asn Glu Xaa 
                165             


<210> 5922
<211> 366
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<400> 5922
Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
1               5                   10                  15      


Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 
            20                  25                  30          


Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 
        35                  40                  45              


Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 
    50                  55                  60                  


Arg Ile Asp Leu Lys Xaa Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 
65                  70                  75                  80  


Gly Ala Gly Xaa Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 
                85                  90                  95      


Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Leu His Asn Gly Arg Ser 
            100                 105                 110         


Lys Glu Gln Arg Leu Lys Glu Gln Leu Gly Ala Gln Gln Glu Pro Val 
        115                 120                 125             


Lys Lys Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro 
    130                 135                 140                 


Glu Glu Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile 
145                 150                 155                 160 


Ile Asp Cys Ile Gly Asn Glu Xaa Glu Leu Leu Arg Asp Xaa Phe Xaa 
                165                 170                 175     


Ser Leu Gly Tyr Glu Val Gln Lys Phe Leu His Leu Ser Met His Gly 
            180                 185                 190         


Ile Ser Gln Ile Leu Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp 
        195                 200                 205             


Tyr Asp Ser Phe Val Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser 
    210                 215                 220                 


Val Tyr Gly Val Asp Gln Xaa His Ser Gly Leu Pro Leu His His Ile 
225                 230                 235                 240 


Arg Arg Met Phe Met Gly Asp Ser Cys Pro Tyr Leu Ala Gly Lys Pro 
                245                 250                 255     


Lys Met Phe Phe Ile Gln Asn Tyr Val Val Ser Glu Gly Gln Leu Glu 
            260                 265                 270         


Asp Ser Ser Leu Leu Glu Val Asp Gly Pro Ala Met Lys Asn Val Glu 
        275                 280                 285             


Phe Lys Ala Gln Lys Arg Gly Leu Cys Xaa Val His Arg Glu Ala Asp 
    290                 295                 300                 


Phe Phe Trp Ser Leu Cys Xaa Ala Asp Met Ser Leu Leu Glu Gln Ser 
305                 310                 315                 320 


His Ser Ser Pro Ser Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg 
                325                 330                 335     


Gln Glu Arg Gly Xaa Ile Pro Gly Ser Gly Ile Xaa Glu Ser Lys Asp 
            340                 345                 350         


Met His Phe Ser Ser Leu Gly Cys Ile Leu Leu Asp Val Leu 
        355                 360                 365     


<210> 5923
<211> 384
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<400> 5923
Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
1               5                   10                  15      


Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 
            20                  25                  30          


Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 
        35                  40                  45              


Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 
    50                  55                  60                  


Arg Ile Asp Leu Lys Xaa Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 
65                  70                  75                  80  


Gly Ala Gly Xaa Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 
                85                  90                  95      


Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Leu His Asn Gly Arg Ser 
            100                 105                 110         


Lys Glu Gln Arg Leu Lys Glu Gln Leu Gly Ala Gln Gln Glu Pro Val 
        115                 120                 125             


Lys Lys Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro 
    130                 135                 140                 


Glu Glu Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile 
145                 150                 155                 160 


Ile Asp Cys Ile Gly Asn Glu Xaa Glu Leu Leu Arg Asp Xaa Phe Xaa 
                165                 170                 175     


Ser Leu Gly Tyr Glu Val Gln Lys Phe Leu His Leu Ser Met His Gly 
            180                 185                 190         


Ile Ser Gln Ile Leu Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp 
        195                 200                 205             


Tyr Asp Ser Phe Val Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser 
    210                 215                 220                 


Val Tyr Gly Val Asp Gln Xaa His Ser Gly Leu Pro Leu His His Ile 
225                 230                 235                 240 


Arg Arg Met Phe Met Gly Asp Ser Cys Pro Tyr Leu Ala Gly Lys Pro 
                245                 250                 255     


Lys Met Phe Phe Ile Gln Asn Tyr Val Val Ser Glu Gly Gln Leu Glu 
            260                 265                 270         


Asp Ser Ser Leu Leu Glu Val Asp Gly Pro Ala Met Lys Asn Val Glu 
        275                 280                 285             


Phe Lys Ala Gln Lys Arg Gly Leu Cys Xaa Val His Arg Glu Ala Asp 
    290                 295                 300                 


Phe Phe Trp Ser Leu Cys Xaa Ala Asp Met Ser Leu Leu Glu Gln Ser 
305                 310                 315                 320 


His Ser Ser Pro Ser Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg 
                325                 330                 335     


Gln Glu Arg Lys Arg Pro Leu Leu Asp Leu His Ile Glu Leu Asn Gly 
            340                 345                 350         


Tyr Met Tyr Asp Trp Asn Ser Arg Val Ser Ala Lys Glu Lys Tyr Tyr 
        355                 360                 365             


Val Trp Leu Gln His Xaa Leu Arg Lys Lys Leu Ile Leu Ser Tyr Xaa 
    370                 375                 380                 


<210> 5924
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<400> 5924
Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
1               5                   10                  15      


Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 
            20                  25                  30          


Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 
        35                  40                  45              


Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 
    50                  55                  60                  


Arg Ile Asp Leu Lys Xaa Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 
65                  70                  75                  80  


Gly Ala Gly Xaa Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 
                85                  90                  95      


Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Met Ile Xaa Pro Tyr Ala 
            100                 105                 110         


His Cys Pro Asp Leu 
        115         


<210> 5925
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<400> 5925
Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
1               5                   10                  15      


Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 
            20                  25                  30          


Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 
        35                  40                  45              


Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 
    50                  55                  60                  


Arg Ile Asp Leu Lys Xaa Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 
65                  70                  75                  80  


Gly Ala Gly Xaa Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 
                85                  90                  95      


Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Val Ser Leu Glu Lys Xaa 
            100                 105                 110         


Tyr Gly Ile Pro Ala 
        115         


<210> 5926
<211> 62
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<400> 5926
Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Xaa Asp 
1               5                   10                  15      


Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 
            20                  25                  30          


Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 
        35                  40                  45              


Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val 
    50                  55                  60          


<210> 5927
<211> 64
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<400> 5927
Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Xaa Asp 
1               5                   10                  15      


Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 
            20                  25                  30          


Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 
        35                  40                  45              


Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 
    50                  55                  60                  


<210> 5928
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 5928
Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Xaa Asp 
1               5                   10                  15      


Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 
            20                  25                  30          


Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 
        35                  40                  45              


Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 
    50                  55                  60                  


Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 
65                  70                  75                  80  


Xaa His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 
                85                  90                  95      


Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
            100                 105                 110         


Ile Phe Leu Met Lys Asp 
        115             


<210> 5929
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 5929
Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Xaa Asp 
1               5                   10                  15      


Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 
            20                  25                  30          


Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 
        35                  40                  45              


Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 
    50                  55                  60                  


Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 
65                  70                  75                  80  


Xaa His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 
                85                  90                  95      


Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
            100                 105                 110         


Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 
        115                 120                 125             


Lys 
    


<210> 5930
<211> 250
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<400> 5930
Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Xaa Asp 
1               5                   10                  15      


Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 
            20                  25                  30          


Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 
        35                  40                  45              


Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 
    50                  55                  60                  


Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 
65                  70                  75                  80  


Xaa His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 
                85                  90                  95      


Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
            100                 105                 110         


Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 
        115                 120                 125             


Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 
    130                 135                 140                 


Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 
145                 150                 155                 160 


Arg Ile Asp Leu Lys Xaa Lys Ile Gln Lys Tyr Lys Gln Ser Gly Gly 
                165                 170                 175     


Trp Asn Gly Xaa Trp Met Xaa Lys Ala Ser Phe Ser Leu Trp Leu Glu 
            180                 185                 190         


Ile Ala Ser Leu Tyr Ile Leu His Ile Pro Asp Leu Pro Xaa Pro Leu 
        195                 200                 205             


Pro Cys Ile Phe Met Ile Ser Ala Lys Cys Cys Gln Ala Val Leu Asn 
    210                 215                 220                 


Ile Ser Val Phe Lys Lys Glu Ser Gly Ile Cys Xaa Gly Trp Gln Ser 
225                 230                 235                 240 


Tyr Gly His Ser Gly Val Leu His Val Cys 
                245                 250 


<210> 5931
<211> 243
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<400> 5931
Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Xaa Asp 
1               5                   10                  15      


Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 
            20                  25                  30          


Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 
        35                  40                  45              


Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 
    50                  55                  60                  


Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 
65                  70                  75                  80  


Xaa His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 
                85                  90                  95      


Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
            100                 105                 110         


Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 
        115                 120                 125             


Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 
    130                 135                 140                 


Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 
145                 150                 155                 160 


Arg Ile Asp Leu Lys Xaa Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 
                165                 170                 175     


Gly Ala Gly Xaa Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 
            180                 185                 190         


Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Ala Gly Val Gln Trp Arg 
        195                 200                 205             


Asp Leu Gly Ser Pro Gln Pro Pro Pro Pro Gly Phe Lys Arg Phe Ser 
    210                 215                 220                 


His Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg Asn Val Pro Pro Arg 
225                 230                 235                 240 


Pro Ala Pro 
            


<210> 5932
<211> 292
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<400> 5932
Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Xaa Asp 
1               5                   10                  15      


Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 
            20                  25                  30          


Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 
        35                  40                  45              


Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 
    50                  55                  60                  


Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 
65                  70                  75                  80  


Xaa His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 
                85                  90                  95      


Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
            100                 105                 110         


Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 
        115                 120                 125             


Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 
    130                 135                 140                 


Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 
145                 150                 155                 160 


Arg Ile Asp Leu Lys Xaa Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 
                165                 170                 175     


Gly Ala Gly Xaa Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 
            180                 185                 190         


Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Leu His Asn Gly Arg Ser 
        195                 200                 205             


Lys Glu Gln Arg Leu Lys Glu Gln Leu Gly Ala Gln Gln Glu Pro Val 
    210                 215                 220                 


Lys Lys Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro 
225                 230                 235                 240 


Glu Glu Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile 
                245                 250                 255     


Ile Asp Cys Ile Gly Asn Glu Xaa Gly Trp Ser Ala Met Ala Gln Ser 
            260                 265                 270         


Gln Leu Xaa Ala Ile Ser Xaa Ser Gln Val Gln Ala Ile Leu Leu Pro 
        275                 280                 285             


Gln Pro Pro Glu 
    290         


<210> 5933
<211> 462
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<400> 5933
Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Xaa Asp 
1               5                   10                  15      


Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 
            20                  25                  30          


Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 
        35                  40                  45              


Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 
    50                  55                  60                  


Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 
65                  70                  75                  80  


Xaa His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 
                85                  90                  95      


Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
            100                 105                 110         


Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 
        115                 120                 125             


Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 
    130                 135                 140                 


Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 
145                 150                 155                 160 


Arg Ile Asp Leu Lys Xaa Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 
                165                 170                 175     


Gly Ala Gly Xaa Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 
            180                 185                 190         


Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Leu His Asn Gly Arg Ser 
        195                 200                 205             


Lys Glu Gln Arg Leu Lys Glu Gln Leu Gly Ala Gln Gln Glu Pro Val 
    210                 215                 220                 


Lys Lys Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro 
225                 230                 235                 240 


Glu Glu Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile 
                245                 250                 255     


Ile Asp Cys Ile Gly Asn Glu Xaa Glu Leu Leu Arg Asp Xaa Phe Xaa 
            260                 265                 270         


Ser Leu Gly Tyr Glu Val Gln Lys Phe Leu His Leu Ser Met His Gly 
        275                 280                 285             


Ile Ser Gln Ile Leu Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp 
    290                 295                 300                 


Tyr Asp Ser Phe Val Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser 
305                 310                 315                 320 


Val Tyr Gly Val Asp Gln Xaa His Ser Gly Leu Pro Leu His His Ile 
                325                 330                 335     


Arg Arg Met Phe Met Gly Asp Ser Cys Pro Tyr Leu Ala Gly Lys Pro 
            340                 345                 350         


Lys Met Phe Phe Ile Gln Asn Tyr Val Val Ser Glu Gly Gln Leu Glu 
        355                 360                 365             


Asp Ser Ser Leu Leu Glu Val Asp Gly Pro Ala Met Lys Asn Val Glu 
    370                 375                 380                 


Phe Lys Ala Gln Lys Arg Gly Leu Cys Xaa Val His Arg Glu Ala Asp 
385                 390                 395                 400 


Phe Phe Trp Ser Leu Cys Xaa Ala Asp Met Ser Leu Leu Glu Gln Ser 
                405                 410                 415     


His Ser Ser Pro Ser Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg 
            420                 425                 430         


Gln Glu Arg Gly Xaa Ile Pro Gly Ser Gly Ile Xaa Glu Ser Lys Asp 
        435                 440                 445             


Met His Phe Ser Ser Leu Gly Cys Ile Leu Leu Asp Val Leu 
    450                 455                 460         


<210> 5934
<211> 480
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<400> 5934
Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Xaa Asp 
1               5                   10                  15      


Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 
            20                  25                  30          


Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 
        35                  40                  45              


Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 
    50                  55                  60                  


Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 
65                  70                  75                  80  


Xaa His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 
                85                  90                  95      


Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
            100                 105                 110         


Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 
        115                 120                 125             


Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 
    130                 135                 140                 


Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 
145                 150                 155                 160 


Arg Ile Asp Leu Lys Xaa Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 
                165                 170                 175     


Gly Ala Gly Xaa Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 
            180                 185                 190         


Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Leu His Asn Gly Arg Ser 
        195                 200                 205             


Lys Glu Gln Arg Leu Lys Glu Gln Leu Gly Ala Gln Gln Glu Pro Val 
    210                 215                 220                 


Lys Lys Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro 
225                 230                 235                 240 


Glu Glu Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile 
                245                 250                 255     


Ile Asp Cys Ile Gly Asn Glu Xaa Glu Leu Leu Arg Asp Xaa Phe Xaa 
            260                 265                 270         


Ser Leu Gly Tyr Glu Val Gln Lys Phe Leu His Leu Ser Met His Gly 
        275                 280                 285             


Ile Ser Gln Ile Leu Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp 
    290                 295                 300                 


Tyr Asp Ser Phe Val Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser 
305                 310                 315                 320 


Val Tyr Gly Val Asp Gln Xaa His Ser Gly Leu Pro Leu His His Ile 
                325                 330                 335     


Arg Arg Met Phe Met Gly Asp Ser Cys Pro Tyr Leu Ala Gly Lys Pro 
            340                 345                 350         


Lys Met Phe Phe Ile Gln Asn Tyr Val Val Ser Glu Gly Gln Leu Glu 
        355                 360                 365             


Asp Ser Ser Leu Leu Glu Val Asp Gly Pro Ala Met Lys Asn Val Glu 
    370                 375                 380                 


Phe Lys Ala Gln Lys Arg Gly Leu Cys Xaa Val His Arg Glu Ala Asp 
385                 390                 395                 400 


Phe Phe Trp Ser Leu Cys Xaa Ala Asp Met Ser Leu Leu Glu Gln Ser 
                405                 410                 415     


His Ser Ser Pro Ser Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg 
            420                 425                 430         


Gln Glu Arg Lys Arg Pro Leu Leu Asp Leu His Ile Glu Leu Asn Gly 
        435                 440                 445             


Tyr Met Tyr Asp Trp Asn Ser Arg Val Ser Ala Lys Glu Lys Tyr Tyr 
    450                 455                 460                 


Val Trp Leu Gln His Xaa Leu Arg Lys Lys Leu Ile Leu Ser Tyr Xaa 
465                 470                 475                 480 


<210> 5935
<211> 221
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<400> 5935
Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Xaa Asp 
1               5                   10                  15      


Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 
            20                  25                  30          


Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 
        35                  40                  45              


Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 
    50                  55                  60                  


Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 
65                  70                  75                  80  


Xaa His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 
                85                  90                  95      


Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
            100                 105                 110         


Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 
        115                 120                 125             


Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 
    130                 135                 140                 


Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 
145                 150                 155                 160 


Arg Ile Asp Leu Lys Xaa Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 
                165                 170                 175     


Gly Ala Gly Xaa Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 
            180                 185                 190         


Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Met Ile Xaa Pro Tyr Ala 
        195                 200                 205             


His Cys Pro Asp Leu Lys Ile Leu Gly Asn Cys Ser Met 
    210                 215                 220     


<210> 5936
<211> 445
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<400> 5936
Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Xaa Asp 
1               5                   10                  15      


Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 
            20                  25                  30          


Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 
        35                  40                  45              


Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 
    50                  55                  60                  


Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 
65                  70                  75                  80  


Xaa His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 
                85                  90                  95      


Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
            100                 105                 110         


Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 
        115                 120                 125             


Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 
    130                 135                 140                 


Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 
145                 150                 155                 160 


Arg Ile Asp Leu Lys Xaa Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 
                165                 170                 175     


Gly Ala Gly Xaa Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 
            180                 185                 190         


Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Ser Ile Pro Glu Glu Arg 
        195                 200                 205             


Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile Ile Asp Cys 
    210                 215                 220                 


Ile Gly Asn Glu Xaa Glu Leu Leu Arg Asp Xaa Phe Xaa Ser Leu Gly 
225                 230                 235                 240 


Tyr Glu Val Gln Lys Phe Leu His Leu Ser Met His Gly Ile Ser Gln 
                245                 250                 255     


Ile Leu Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp Tyr Asp Ser 
            260                 265                 270         


Phe Val Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser Val Tyr Gly 
        275                 280                 285             


Val Asp Gln Xaa His Ser Gly Leu Pro Leu His His Ile Arg Arg Met 
    290                 295                 300                 


Phe Met Gly Asp Ser Cys Pro Tyr Leu Ala Gly Lys Pro Lys Met Phe 
305                 310                 315                 320 


Phe Ile Gln Asn Tyr Val Val Ser Glu Gly Gln Leu Glu Asp Ser Ser 
                325                 330                 335     


Leu Leu Glu Val Asp Gly Pro Ala Met Lys Asn Val Glu Phe Lys Ala 
            340                 345                 350         


Gln Lys Arg Gly Leu Cys Xaa Val His Arg Glu Ala Asp Phe Phe Trp 
        355                 360                 365             


Ser Leu Cys Xaa Ala Asp Met Ser Leu Leu Glu Gln Ser His Ser Ser 
    370                 375                 380                 


Pro Ser Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg Gln Glu Arg 
385                 390                 395                 400 


Lys Arg Pro Leu Leu Asp Leu His Ile Glu Leu Asn Gly Tyr Met Tyr 
                405                 410                 415     


Asp Trp Asn Ser Arg Val Ser Ala Lys Glu Lys Tyr Tyr Val Trp Leu 
            420                 425                 430         


Gln His Xaa Leu Arg Lys Lys Leu Ile Leu Ser Tyr Xaa 
        435                 440                 445 


<210> 5937
<211> 62
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<400> 5937
Met Asp Tyr Tyr Arg Lys Tyr Ala Ala Ile Phe Leu Val Xaa Leu Ser 
1               5                   10                  15      


Val Phe Leu His Val Leu His Ser Ala Pro Asp Val Gln Asp Cys Pro 
            20                  25                  30          


Glu Cys Xaa Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro 
        35                  40                  45              


Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro 
    50                  55                  60          


<210> 5938
<211> 101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<400> 5938
Met Asp Tyr Tyr Arg Lys Tyr Ala Ala Ile Phe Leu Val Xaa Leu Ser 
1               5                   10                  15      


Val Phe Leu His Val Leu His Ser Ala Pro Asp Val Gln Asp Cys Pro 
            20                  25                  30          


Glu Cys Xaa Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro 
        35                  40                  45              


Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Xaa Pro 
    50                  55                  60                  


Leu Arg Ser Lys Lys Xaa Met Leu Val Gln Lys Asn Val Xaa Ser Glu 
65                  70                  75                  80  


Ser Xaa Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Arg Xaa Ser Arg 
                85                  90                  95      


Ser Pro Glu Ala Phe 
            100     


<210> 5939
<211> 116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 5939
Met Asp Tyr Tyr Arg Lys Tyr Ala Ala Ile Phe Leu Val Xaa Leu Ser 
1               5                   10                  15      


Val Phe Leu His Val Leu His Ser Ala Pro Asp Val Gln Asp Cys Pro 
            20                  25                  30          


Glu Cys Xaa Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro 
        35                  40                  45              


Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Xaa Pro 
    50                  55                  60                  


Leu Arg Ser Lys Lys Xaa Met Leu Val Gln Lys Asn Val Xaa Ser Glu 
65                  70                  75                  80  


Ser Xaa Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Xaa Val Met Gly 
                85                  90                  95      


Gly Phe Lys Val Glu Asn His Xaa Ala Cys His Cys Ser Xaa Cys Tyr 
            100                 105                 110         


Tyr His Lys Ser 
        115     


<210> 5940
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<400> 5940
Met Asp Tyr Tyr Arg Lys Tyr Ala Ala Ile Phe Leu Val Xaa Leu Ser 
1               5                   10                  15      


Val Phe Leu His Val Leu His Ser Ala Pro Asp Val Gln Glu Xaa Gly 
            20                  25                  30          


Phe His His Val Ala Gln Ala Ala Leu Lys Leu Leu Ser Ser Ser Asn 
        35                  40                  45              


Pro Pro Xaa Lys Ala Ser Gln Ser Ala Arg Ile Xaa Asp Cys Pro Glu 
    50                  55                  60                  


Cys Xaa Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro Ile 
65                  70                  75                  80  


Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Xaa Pro Leu 
                85                  90                  95      


Arg Ser Lys Lys Xaa Met Leu Val Gln Lys Asn Val Xaa Ser Glu Ser 
            100                 105                 110         


Xaa Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Xaa Val Met Gly Gly 
        115                 120                 125             


Phe Lys Val Glu Asn His Xaa Ala Cys His Cys Ser Xaa Cys Tyr Tyr 
    130                 135                 140                 


His Lys Ser 
145         


<210> 5941
<211> 116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 5941
Met Gln Leu Ser Phe Trp Ser His Cys Arg Cys Phe Cys Met Phe Ser 
1               5                   10                  15      


Ile Pro Leu Leu Met Cys Arg Val Arg Asp Gln Ile Cys Asp Cys Pro 
            20                  25                  30          


Glu Cys Xaa Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro 
        35                  40                  45              


Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Xaa Pro 
    50                  55                  60                  


Leu Arg Ser Lys Lys Xaa Met Leu Val Gln Lys Asn Val Xaa Ser Glu 
65                  70                  75                  80  


Ser Xaa Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Xaa Val Met Gly 
                85                  90                  95      


Gly Phe Lys Val Glu Asn His Xaa Ala Cys His Cys Ser Xaa Cys Tyr 
            100                 105                 110         


Tyr His Lys Ser 
        115     


<210> 5942
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 5942
Met Gly Gly Xaa Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg 
1               5                   10                  15      


Pro Ile Asn Ala Xaa Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys 
            20                  25                  30          


Ile Xaa Val Asn Xaa Xaa Ile Cys Ala Gly Tyr Cys Pro Xaa Met Xaa 
        35                  40                  45              


Arg Val Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn 
    50                  55                  60                  


Tyr Arg Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg 
65                  70                  75                  80  


Gly Val Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys 
                85                  90                  95      


Ala Leu Cys Arg Arg Ser Xaa Xaa Asp Cys Gly Gly Pro Lys Asp His 
            100                 105                 110         


Pro Leu Xaa Cys Asp Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys 
        115                 120                 125             


Ala Pro 
    130 


<210> 5943
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 5943
Met Ser Lys Arg Leu Leu Leu Leu Leu Leu Leu Ser Met Gly Gly Xaa 
1               5                   10                  15      


Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile Asn Ala 
            20                  25                  30          


Xaa Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Xaa Val Asn 
        35                  40                  45              


Xaa Xaa Ile Cys Ala Gly Tyr Cys Pro Xaa Met Xaa Arg Val Leu Gln 
    50                  55                  60                  


Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg Asp Val 
65                  70                  75                  80  


Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val Asn Pro 
                85                  90                  95      


Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu Cys Arg 
            100                 105                 110         


Arg Ser Xaa Xaa Asp Cys Gly Gly Pro Lys Asp His Pro Leu Xaa Cys 
        115                 120                 125             


Asp Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro 
    130                 135                 140                 


Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro 
145                 150                 155 


<210> 5944
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 5944
Met Glu Gln Ala Pro Asn Met Ala Glu Pro Arg Gly Pro Val Asp His 
1               5                   10                  15      


Gly Val Gln Ile Arg Phe Ile Xaa Glu Pro Val Ser Gly Ala Glu Met 
            20                  25                  30          


Gly Xaa Leu Arg Arg Gly Gly Arg Arg Pro Ala Lys Asp Ala Arg Ala 
        35                  40                  45              


Ser Xaa Tyr Gly Val Ala Val Arg Val Gln Gly Ile Ala Gly Gln Pro 
    50                  55                  60                  


Phe Val Val Leu Asn Ser Gly Glu Lys Gly Gly Asp Ser Phe Gly Val 
65                  70                  75                  80  


Gln Ile Lys Gly Ala Asn Asp Gln Gly Ala Ser Gly Ala Leu Ser Ser 
                85                  90                  95      


Asp Leu Glu Leu Pro Glu Asn Pro Tyr Ser Gln Val Lys Gly Phe Pro 
            100                 105                 110         


Ala Pro Ser Gln Ser Ser Xaa Ser Asp Glu Glu Pro Gly Ala Tyr Trp 
        115                 120                 125             


Asn Gly Lys Leu Leu Arg Ser His Ser Gln Ala Ser Leu Ala Gly Pro 
    130                 135                 140                 


Gly Pro Val Asp Pro Ser Asn Arg Ser Asn Ser Met Leu Glu Leu Ala 
145                 150                 155                 160 


Pro Lys Val Ala Ser Pro Gly Ser Xaa Ile 
                165                 170 


<210> 5945
<211> 291
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<400> 5945
Met Glu Gln Ala Pro Asn Met Ala Glu Pro Arg Gly Pro Val Asp His 
1               5                   10                  15      


Gly Val Gln Ile Arg Phe Ile Xaa Glu Pro Val Ser Gly Ala Glu Met 
            20                  25                  30          


Gly Xaa Leu Arg Arg Gly Gly Arg Arg Pro Ala Lys Asp Ala Arg Ala 
        35                  40                  45              


Ser Xaa Tyr Gly Val Ala Val Arg Val Gln Gly Ile Ala Gly Gln Pro 
    50                  55                  60                  


Phe Val Val Leu Asn Ser Gly Glu Lys Gly Gly Asp Ser Phe Gly Val 
65                  70                  75                  80  


Gln Ile Lys Gly Ala Asn Asp Gln Gly Ala Ser Gly Ala Leu Ser Ser 
                85                  90                  95      


Asp Leu Glu Leu Pro Glu Asn Pro Tyr Ser Gln Val Lys Gly Phe Pro 
            100                 105                 110         


Ala Pro Ser Gln Ser Ser Xaa Ser Asp Glu Glu Pro Gly Ala Tyr Trp 
        115                 120                 125             


Asn Gly Lys Leu Leu Arg Ser His Ser Gln Ala Ser Leu Ala Gly Pro 
    130                 135                 140                 


Gly Pro Val Asp Pro Ser Asn Arg Ser Asn Ser Met Leu Glu Leu Ala 
145                 150                 155                 160 


Pro Lys Val Ala Ser Pro Gly Ser Xaa Ile Asp Xaa Ala Pro Leu Ser 
                165                 170                 175     


Ser Val Asp Ser Leu Ile Asn Lys Phe Asp Ser Gln Leu Gly Gly Gln 
            180                 185                 190         


Ala Arg Gly Arg Xaa Gly Arg Arg Xaa Arg Met Leu Pro Pro Glu Gln 
        195                 200                 205             


Arg Lys Arg Ser Lys Ser Leu Asp Ser Arg Leu Pro Arg Asp Xaa Phe 
    210                 215                 220                 


Glu Glu Arg Glu Arg Gln Ser Xaa Asn His Trp Xaa Ser Ser Xaa Lys 
225                 230                 235                 240 


Tyr Asp Asn His Val Gly Xaa Ser Lys Gln Pro Ala Gln Ser Gln Asn 
                245                 250                 255     


Leu Ser Pro Leu Ser Gly Phe Ser Arg Ser Arg Gln Xaa Gln Asp Trp 
            260                 265                 270         


Val Leu Gln Ser Phe Glu Glu Pro Arg Arg Ser Ala Gln Asp Pro Xaa 
        275                 280                 285             


Met Leu Gln 
    290     


<210> 5946
<211> 1203
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1200)..(1200)
<223> Selenocysteine

<400> 5946
Met Glu Gln Ala Pro Asn Met Ala Glu Pro Arg Gly Pro Val Asp His 
1               5                   10                  15      


Gly Val Gln Ile Arg Phe Ile Xaa Glu Pro Val Ser Gly Ala Glu Met 
            20                  25                  30          


Gly Xaa Leu Arg Arg Gly Gly Arg Arg Pro Ala Lys Asp Ala Arg Ala 
        35                  40                  45              


Ser Xaa Tyr Gly Val Ala Val Arg Val Gln Gly Ile Ala Gly Gln Pro 
    50                  55                  60                  


Phe Val Val Leu Asn Ser Gly Glu Lys Gly Gly Asp Ser Phe Gly Val 
65                  70                  75                  80  


Gln Ile Lys Gly Ala Asn Asp Gln Gly Ala Ser Gly Ala Leu Ser Ser 
                85                  90                  95      


Asp Leu Glu Leu Pro Glu Asn Pro Tyr Ser Gln Val Lys Gly Phe Pro 
            100                 105                 110         


Ala Pro Ser Gln Ser Ser Xaa Ser Asp Glu Glu Pro Gly Ala Tyr Trp 
        115                 120                 125             


Asn Gly Lys Leu Leu Arg Ser His Ser Gln Ala Ser Leu Ala Gly Pro 
    130                 135                 140                 


Gly Pro Val Asp Pro Ser Asn Arg Ser Asn Ser Met Leu Glu Leu Ala 
145                 150                 155                 160 


Pro Lys Val Ala Ser Pro Gly Ser Xaa Ile Asp Xaa Ala Pro Leu Ser 
                165                 170                 175     


Ser Val Asp Ser Leu Ile Asn Lys Phe Asp Ser Gln Leu Gly Gly Gln 
            180                 185                 190         


Ala Arg Gly Arg Xaa Gly Arg Arg Xaa Arg Met Leu Pro Pro Glu Gln 
        195                 200                 205             


Arg Lys Arg Ser Lys Ser Leu Asp Ser Arg Leu Pro Arg Asp Xaa Phe 
    210                 215                 220                 


Glu Glu Arg Glu Arg Gln Ser Xaa Asn His Trp Xaa Ser Ser Xaa Lys 
225                 230                 235                 240 


Tyr Asp Asn His Val Gly Xaa Ser Lys Gln Pro Ala Gln Ser Gln Asn 
                245                 250                 255     


Leu Ser Pro Leu Ser Gly Phe Ser Arg Ser Arg Gln Xaa Gln Asp Trp 
            260                 265                 270         


Val Leu Gln Ser Phe Glu Glu Pro Arg Arg Ser Ala Gln Asp Pro Xaa 
        275                 280                 285             


Met Leu Gln Phe Lys Ser Xaa Pro Asp Leu Leu Arg Asp Gln Gln Glu 
    290                 295                 300                 


Ala Ala Pro Pro Gly Ser Val Asp His Met Lys Ala Xaa Ile Tyr Gly 
305                 310                 315                 320 


Ile Leu Arg Glu Gly Ser Ser Glu Ser Glu Xaa Ser Val Arg Arg Lys 
                325                 330                 335     


Val Ser Leu Val Leu Glu Lys Met Gln Pro Leu Val Met Val Ser Ser 
            340                 345                 350         


Gly Ser Xaa Lys Ala Val Ala Gly Gln Gly Glu Leu Xaa Arg Lys Val 
        355                 360                 365             


Glu Glu Leu Gln Arg Lys Leu Asp Glu Glu Val Lys Lys Arg Gln Lys 
    370                 375                 380                 


Leu Glu Pro Ser Gln Val Gly Leu Glu Arg Gln Leu Glu Glu Lys Xaa 
385                 390                 395                 400 


Glu Glu Cys Ser Arg Leu Gln Glu Leu Leu Glu Arg Arg Lys Gly Glu 
                405                 410                 415     


Ala Gln Gln Ser Asn Lys Glu Leu Gln Asn Met Lys Arg Leu Leu Asp 
            420                 425                 430         


Gln Gly Glu Asp Leu Arg His Gly Leu Glu Xaa Gln Val Met Glu Leu 
        435                 440                 445             


Gln Asn Lys Leu Lys His Val Gln Gly Pro Glu Pro Ala Lys Glu Val 
    450                 455                 460                 


Leu Leu Lys Asp Leu Leu Glu Xaa Arg Glu Leu Leu Glu Glu Val Leu 
465                 470                 475                 480 


Glu Gly Lys Gln Arg Val Glu Glu Gln Leu Arg Leu Arg Glu Arg Glu 
                485                 490                 495     


Leu Xaa Ala Leu Lys Gly Ala Leu Lys Glu Glu Val Ala Ser Arg Asp 
            500                 505                 510         


Gln Glu Val Glu His Val Arg Gln Gln Tyr Gln Arg Asp Xaa Glu Gln 
        515                 520                 525             


Leu Arg Arg Ser Met Gln Asp Ala Xaa Gln Asp His Ala Val Leu Glu 
    530                 535                 540                 


Ala Glu Arg Gln Lys Met Ser Ala Leu Val Arg Gly Leu Gln Arg Glu 
545                 550                 555                 560 


Leu Glu Glu Xaa Ser Glu Glu Xaa Gly His Trp Gln Ser Met Phe Gln 
                565                 570                 575     


Lys Asn Lys Glu Asp Leu Arg Ala Xaa Lys Gln Glu Leu Leu Gln Leu 
            580                 585                 590         


Arg Met Glu Lys Glu Glu Met Glu Glu Glu Leu Gly Glu Lys Ile Glu 
        595                 600                 605             


Val Leu Gln Arg Glu Leu Glu Gln Ala Arg Ala Ser Ala Gly Asp Xaa 
    610                 615                 620                 


Arg Gln Val Glu Val Leu Lys Lys Glu Leu Leu Arg Xaa Gln Glu Glu 
625                 630                 635                 640 


Leu Lys Glu Leu Gln Ala Glu Arg Gln Ser Gln Glu Val Ala Gly Arg 
                645                 650                 655     


His Arg Asp Arg Glu Leu Glu Lys Gln Leu Ala Val Leu Arg Val Glu 
            660                 665                 670         


Ala Asp Arg Gly Arg Glu Leu Glu Glu Gln Asn Leu Gln Leu Gln Lys 
        675                 680                 685             


Xaa Leu Gln Gln Leu Arg Gln Asp Cys Glu Glu Ala Ser Lys Ala Lys 
    690                 695                 700                 


Met Val Ala Glu Ala Glu Ala Xaa Val Leu Gly Gln Arg Arg Ala Ala 
705                 710                 715                 720 


Val Glu Xaa Xaa Leu Arg Glu Xaa Gln Glu Glu Asn Asp Glu Phe Arg 
                725                 730                 735     


Arg Arg Ile Leu Gly Leu Glu Gln Gln Leu Lys Glu Xaa Arg Gly Leu 
            740                 745                 750         


Val Asp Gly Gly Glu Ala Val Glu Ala Arg Leu Arg Asp Lys Leu Gln 
        755                 760                 765             


Arg Leu Glu Ala Glu Lys Gln Gln Leu Glu Glu Ala Leu Asn Ala Ser 
    770                 775                 780                 


Gln Glu Glu Glu Gly Ser Leu Ala Ala Ala Lys Arg Ala Leu Glu Ala 
785                 790                 795                 800 


Arg Leu Glu Glu Ala Gln Arg Gly Leu Ala Arg Leu Gly Gln Glu Gln 
                805                 810                 815     


Gln Xaa Leu Asn Arg Ala Leu Glu Glu Glu Gly Lys Gln Arg Glu Val 
            820                 825                 830         


Leu Arg Arg Gly Lys Ala Glu Leu Glu Glu Gln Lys Arg Leu Leu Asp 
        835                 840                 845             


Arg Xaa Val Asp Arg Leu Asn Lys Glu Leu Glu Lys Ile Gly Glu Asp 
    850                 855                 860                 


Ser Lys Gln Ala Leu Gln Gln Leu Gln Ala Gln Leu Glu Asp Tyr Lys 
865                 870                 875                 880 


Glu Lys Ala Arg Arg Glu Val Ala Asp Ala Gln Arg Gln Ala Lys Asp 
                885                 890                 895     


Trp Ala Ser Glu Ala Glu Lys Xaa Ser Gly Gly Leu Ser Arg Leu Gln 
            900                 905                 910         


Asp Glu Ile Gln Arg Leu Arg Gln Ala Leu Gln Ala Ser Gln Ala Glu 
        915                 920                 925             


Arg Asp Xaa Ala Arg Leu Asp Lys Glu Leu Leu Ala Gln Arg Leu Gln 
    930                 935                 940                 


Gly Leu Glu Gln Glu Ala Glu Asn Lys Lys Arg Ser Gln Asp Asp Arg 
945                 950                 955                 960 


Ala Arg Gln Leu Lys Gly Leu Glu Glu Lys Val Ser Arg Leu Glu Xaa 
                965                 970                 975     


Glu Leu Asp Glu Glu Lys Asn Xaa Val Glu Leu Leu Xaa Asp Arg Val 
            980                 985                 990         


Asn Arg Gly Arg Asp Gln Val Asp  Gln Leu Arg Xaa Glu  Leu Met Gln 
        995                 1000                 1005             


Glu Arg  Ser Ala Arg Gln Asp  Leu Glu Cys Asp Lys  Ile Ser Leu 
    1010                 1015                 1020             


Glu Arg  Gln Asn Lys Asp Leu  Lys Xaa Arg Leu Ala  Ser Ser Glu 
    1025                 1030                 1035             


Gly Phe  Gln Lys Pro Ser Ala  Ser Leu Ser Gln Leu  Glu Ser Gln 
    1040                 1045                 1050             


Asn Gln  Leu Leu Gln Glu Arg  Leu Gln Ala Glu Glu  Arg Glu Lys 
    1055                 1060                 1065             


Xaa Val  Leu Gln Ser Xaa Asn  Arg Lys Leu Glu Arg  Lys Val Lys 
    1070                 1075                 1080             


Glu Leu  Ser Ile Gln Ile Glu  Asp Glu Arg Gln His  Val Asn Asp 
    1085                 1090                 1095             


Gln Lys  Asp Gln Leu Ser Leu  Arg Val Lys Ala Leu  Lys Arg Gln 
    1100                 1105                 1110             


Val Asp  Glu Ala Glu Glu Glu  Ile Glu Arg Leu Asp  Gly Leu Arg 
    1115                 1120                 1125             


Lys Lys  Ala Gln Arg Glu Val  Glu Glu Gln His Glu  Val Asn Glu 
    1130                 1135                 1140             


Gln Leu  Gln Ala Arg Ile Lys  Ser Leu Glu Lys Asp  Ser Trp Arg 
    1145                 1150                 1155             


Lys Ala  Ser Arg Ser Ala Ala  Glu Ser Ala Leu Lys  Asn Glu Gly 
    1160                 1165                 1170             


Leu Ser  Ser Asp Glu Glu Phe  Asp Ser Val Tyr Asp  Pro Ser Ser 
    1175                 1180                 1185             


Ile Ala  Ser Leu Leu Xaa Glu  Ser Asn Leu Gln Xaa  Ser Ser Cys 
    1190                 1195                 1200             


<210> 5947
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<400> 5947
Xaa Gln Asp Pro Xaa Met Leu Gln Phe Lys Ser Xaa Pro Asp Leu Leu 
1               5                   10                  15      


Arg Asp Gln Gln Glu Ala Ala Pro Pro Gly Ser Val Asp His Met Lys 
            20                  25                  30          


Ala Xaa Ile Tyr Gly Ile Leu Arg Glu Gly Ser Ser Glu Ser Glu Xaa 
        35                  40                  45              


Ser Val Arg Arg Lys Val Ser Leu Val Leu Glu Lys Met Gln Pro Leu 
    50                  55                  60                  


Val Ala Val Ala Gly Gln Gly Glu Leu Xaa Arg Lys Val Glu Glu Leu 
65                  70                  75                  80  


Gln Arg Lys Leu Asp Glu Glu Val Lys Lys Arg Gln Lys Leu Glu Pro 
                85                  90                  95      


Ser Gln Val Gly Leu Glu Arg Gln Leu Glu Glu Lys Xaa Glu Glu Cys 
            100                 105                 110         


Ser Arg Leu Gln Glu Leu Leu Glu Arg Arg Lys Gly Glu Ala Gln Gln 
        115                 120                 125             


Ser Asn Lys 
    130     


<210> 5948
<211> 219
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<400> 5948
Met Gly Gly Ala Gln Leu Glu Leu Pro Ser Gly Ala Arg Pro Gly Val 
1               5                   10                  15      


Cys Val Arg Arg Ser Phe Arg Ala His Ala Gly Asp Gln Pro Arg Arg 
            20                  25                  30          


Pro Pro Gly Pro Ile Pro Val Pro Gly Xaa Met Lys Gln Glu Ser Ala 
        35                  40                  45              


Ala Pro Asn Xaa Pro Pro Xaa Ser Gln Ser Pro Xaa Pro Ser Ala Gln 
    50                  55                  60                  


Phe Pro Arg Asn Asp Gly Asp Pro Gln Ala Leu Trp Ile Phe Gly Tyr 
65                  70                  75                  80  


Gly Ser Leu Val Trp Arg Pro Asp Phe Ala Tyr Ser Asp Ser Arg Val 
                85                  90                  95      


Gly Phe Val Arg Gly Tyr Ser Arg Arg Phe Trp Gln Gly Asp Xaa Phe 
            100                 105                 110         


His Arg Gly Ser Asp Lys Met Pro Gly Arg Val Val Xaa Leu Leu Glu 
        115                 120                 125             


Asp His Glu Gly Cys Xaa Trp Gly Val Ala Tyr Gln Val Gln Gly Glu 
    130                 135                 140                 


Gln Asn Pro Gly Tyr Leu Gly Pro Ala Pro Glu Glu Ala Ile Ala Xaa 
145                 150                 155                 160 


Gln Ile Leu Ala Cys Arg Gly Phe Ser Gly His Asn Leu Glu Tyr Leu 
                165                 170                 175     


Leu Arg Leu Ala Asp Phe Met Gln Leu Cys Gly Pro Gln Ala Gln Asp 
            180                 185                 190         


Glu His Leu Ala Ala Ile Val Asp Ala Val Gly Xaa Met Leu Pro Cys 
        195                 200                 205             


Phe Cys Pro Xaa Glu Gln Ala Leu Ala Leu Val 
    210                 215                 


<210> 5949
<211> 264
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<400> 5949
Met Gly Gly Ala Gln Leu Glu Leu Pro Ser Gly Ala Arg Pro Gly Val 
1               5                   10                  15      


Cys Val Arg Arg Ser Phe Arg Ala His Ala Gly Asp Gln Pro Arg Arg 
            20                  25                  30          


Pro Pro Gly Pro Ile Pro Val Pro Gly Xaa Met Lys Gln Glu Ser Ala 
        35                  40                  45              


Ala Pro Asn Xaa Pro Pro Xaa Ser Gln Ser Pro Xaa Pro Ser Ala Gln 
    50                  55                  60                  


Phe Pro Arg Asn Asp Gly Asp Pro Gln Ala Leu Trp Ile Phe Gly Tyr 
65                  70                  75                  80  


Gly Ser Leu Val Trp Arg Pro Asp Phe Ala Tyr Ser Asp Ser Arg Val 
                85                  90                  95      


Gly Phe Val Arg Gly Tyr Ser Arg Arg Phe Trp Gln Gly Asp Xaa Phe 
            100                 105                 110         


His Arg Gly Ser Asp Lys Met Pro Gly Arg Val Val Xaa Leu Leu Glu 
        115                 120                 125             


Asp His Glu Gly Cys Xaa Trp Gly Val Ala Tyr Gln Val Gln Gly Glu 
    130                 135                 140                 


Gln Val Ser Lys Ala Leu Lys Tyr Leu Asn Val Arg Glu Ala Val Leu 
145                 150                 155                 160 


Gly Gly Tyr Asp Xaa Lys Glu Val Xaa Phe Tyr Pro Gln Asp Ala Pro 
                165                 170                 175     


Asp Gln Pro Leu Lys Ala Leu Ala Tyr Val Ala Xaa Pro Gln Asn Pro 
            180                 185                 190         


Gly Tyr Leu Gly Pro Ala Pro Glu Glu Ala Ile Ala Xaa Gln Ile Leu 
        195                 200                 205             


Ala Cys Arg Gly Phe Ser Gly His Asn Leu Glu Tyr Leu Leu Arg Leu 
    210                 215                 220                 


Ala Asp Phe Met Gln Leu Cys Gly Pro Gln Ala Gln Asp Glu His Leu 
225                 230                 235                 240 


Ala Ala Ile Val Asp Ala Val Gly Xaa Met Leu Pro Cys Phe Cys Pro 
                245                 250                 255     


Xaa Glu Gln Ala Leu Ala Leu Val 
            260                 


<210> 5950
<211> 222
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<400> 5950
Met Lys Gln Glu Ser Ala Ala Pro Asn Xaa Pro Pro Xaa Ser Gln Ser 
1               5                   10                  15      


Pro Xaa Pro Ser Ala Gln Phe Pro Arg Asn Asp Gly Asp Pro Gln Ala 
            20                  25                  30          


Leu Trp Ile Phe Gly Tyr Gly Ser Leu Val Trp Arg Pro Asp Phe Ala 
        35                  40                  45              


Tyr Ser Asp Ser Arg Val Gly Phe Val Arg Gly Tyr Ser Arg Arg Phe 
    50                  55                  60                  


Trp Gln Gly Asp Xaa Phe His Arg Gly Ser Asp Lys Met Pro Gly Arg 
65                  70                  75                  80  


Val Val Xaa Leu Leu Glu Asp His Glu Gly Cys Xaa Trp Gly Val Ala 
                85                  90                  95      


Tyr Gln Val Gln Gly Glu Gln Val Ser Lys Ala Leu Lys Tyr Leu Asn 
            100                 105                 110         


Val Arg Glu Ala Val Leu Gly Gly Tyr Asp Xaa Lys Glu Val Xaa Phe 
        115                 120                 125             


Tyr Pro Gln Asp Ala Pro Asp Gln Pro Leu Lys Ala Leu Ala Tyr Val 
    130                 135                 140                 


Ala Xaa Pro Gln Asn Pro Gly Tyr Leu Gly Pro Ala Pro Glu Glu Ala 
145                 150                 155                 160 


Ile Ala Xaa Gln Ile Leu Ala Cys Arg Gly Phe Ser Gly His Asn Leu 
                165                 170                 175     


Glu Tyr Leu Leu Arg Leu Ala Asp Phe Met Gln Leu Cys Gly Pro Gln 
            180                 185                 190         


Ala Gln Asp Glu His Leu Ala Ala Ile Val Asp Ala Val Gly Xaa Met 
        195                 200                 205             


Leu Pro Cys Phe Cys Pro Xaa Glu Gln Ala Leu Ala Leu Val 
    210                 215                 220         


<210> 5951
<211> 37
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<400> 5951
Met Gln Leu Cys Gly Pro Gln Ala Gln Asp Glu His Leu Ala Ala Ile 
1               5                   10                  15      


Val Asp Ala Val Gly Xaa Met Leu Pro Cys Phe Cys Pro Xaa Glu Gln 
            20                  25                  30          


Ala Leu Ala Leu Val 
        35          


<210> 5952
<211> 359
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<400> 5952
Met Val Arg Pro Met Leu Leu Leu Ser Leu Gly Leu Leu Ala Gly Leu 
1               5                   10                  15      


Leu Pro Ala Leu Ala Ala Cys Pro Gln Asn Cys His Cys His Ser Asp 
            20                  25                  30          


Leu Gln His Val Ile Cys Asp Lys Val Gly Leu Gln Lys Ile Pro Lys 
        35                  40                  45              


Val Ser Glu Lys Xaa Lys Leu Leu Asn Leu Gln Arg Asn Asn Phe Pro 
    50                  55                  60                  


Val Leu Ala Ala Asn Ser Phe Arg Ala Met Pro Asn Leu Val Ser Leu 
65                  70                  75                  80  


His Leu Gln His Cys Gln Ile Arg Glu Val Ala Ala Gly Ala Phe Arg 
                85                  90                  95      


Gly Leu Lys Gln Leu Ile Tyr Leu Tyr Leu Ser His Asn Asp Ile Arg 
            100                 105                 110         


Val Leu Arg Ala Gly Ala Phe Asp Asp Leu Xaa Glu Leu Xaa Tyr Leu 
        115                 120                 125             


Tyr Leu Asp His Asn Lys Val Xaa Glu Leu Pro Arg Gly Leu Leu Ser 
    130                 135                 140                 


Pro Leu Val Asn Leu Phe Ile Leu Gln Leu Asn Asn Asn Lys Ile Arg 
145                 150                 155                 160 


Glu Leu Arg Ala Gly Ala Phe Gln Gly Ala Lys Asp Leu Arg Trp Leu 
                165                 170                 175     


Tyr Leu Ser Glu Asn Ala Leu Ser Ser Leu Gln Pro Gly Ala Leu Asp 
            180                 185                 190         


Asp Val Glu Asn Leu Ala Lys Phe His Val Asp Arg Asn Gln Leu Ser 
        195                 200                 205             


Ser Tyr Pro Ser Ala Ala Leu Ser Lys Leu Arg Val Val Glu Glu Leu 
    210                 215                 220                 


Lys Leu Ser His Asn Pro Leu Lys Ser Ile Pro Asp Asn Ala Phe Gln 
225                 230                 235                 240 


Ser Phe Gly Arg Tyr Leu Glu Xaa Leu Trp Leu Asp Asn Xaa Asn Leu 
                245                 250                 255     


Glu Lys Phe Ser Asp Gly Ala Phe Leu Gly Val Xaa Xaa Leu Lys His 
            260                 265                 270         


Val His Leu Glu Asn Asn Arg Leu Asn Gln Leu Pro Ser Asn Phe Pro 
        275                 280                 285             


Phe Asp Ser Leu Glu Xaa Leu Ala Leu Xaa Asn Asn Pro Trp Lys Cys 
    290                 295                 300                 


Xaa Cys Gln Leu Arg Gly Leu Arg Arg Trp Leu Glu Ala Lys Ala Ser 
305                 310                 315                 320 


Arg Pro Asp Ala Xaa Cys Ala Ser Pro Ala Lys Phe Lys Gly Gln His 
                325                 330                 335     


Ile Arg Asp Xaa Asp Ala Phe Arg Ser Cys Lys Phe Pro Xaa Lys Arg 
            340                 345                 350         


Ser Lys Lys Ala Gly Arg His 
        355                 


<210> 5953
<211> 42
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<400> 5953
Xaa Ala Ser Arg Pro Asp Ala Xaa Cys Ala Ser Pro Ala Lys Phe Lys 
1               5                   10                  15      


Gly Gln His Ile Arg Asp Xaa Asp Ala Phe Arg Ser Cys Lys Phe Pro 
            20                  25                  30          


Xaa Lys Arg Ser Lys Lys Ala Gly Arg His 
        35                  40          


<210> 5954
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<400> 5954
Glu Ser Lys Ser Asp Gly Arg Glu Arg Ser Lys Lys Ser Ser Val Ser 
1               5                   10                  15      


Asp Ala Pro Val His Ile Xaa Ala Ser Gly Glu Pro Val Pro Ile Ser 
            20                  25                  30          


Glu Glu Ser Glu Glu Leu Asp Gln Lys Xaa Phe Ser Ile Cys Lys Glu 
        35                  40                  45              


Arg Met Arg Pro Val Lys Ala Ala Leu Lys Gln Leu Asp Arg Pro Glu 
    50                  55                  60                  


Lys Gly Leu Ser Glu Arg Glu Gln Leu Glu His Xaa Arg Gln Cys Leu 
65                  70                  75                  80  


Ile Lys Ile Gly Asp His Ile Xaa Glu Cys Leu Lys Glu Tyr Xaa Asn 
                85                  90                  95      


Pro Glu Gln Ile Lys Gln Trp Arg Asn Lys Xaa Val Ile Lys Xaa Ala 
            100                 105                 110         


Xaa 
    


<210> 5955
<211> 22
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<400> 5955
Ile Ser Glu Glu Ser Glu Glu Leu Asp Gln Lys Xaa Phe Ser Ile Lys 
1               5                   10                  15      


Pro Val Asp Phe Cys Ile 
            20          


<210> 5956
<211> 1710
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1117)..(1117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1187)..(1187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1190)..(1190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1244)..(1244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1304)..(1304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1394)..(1394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1413)..(1413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1447)..(1447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1459)..(1459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1466)..(1466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1486)..(1486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1534)..(1534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1551)..(1551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1650)..(1650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1700)..(1700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1704)..(1704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1710)..(1710)
<223> Selenocysteine

<400> 5956
Met Asn Gly His Ser Asp Glu Glu Ser Val Arg Asn Ser Ser Gly Glu 
1               5                   10                  15      


Ser Ser Gln Ser Asp Asp Asp Ser Gly Ser Ala Ser Gly Ser Gly Ser 
            20                  25                  30          


Gly Ser Ser Ser Gly Ser Ser Ser Asp Gly Ser Ser Ser Gln Ser Gly 
        35                  40                  45              


Ser Ser Asp Ser Asp Ser Gly Ser Glu Ser Gly Ser Gln Ser Glu Ser 
    50                  55                  60                  


Glu Ser Asp Xaa Ser Arg Glu Asn Lys Val Gln Ala Lys Pro Pro Lys 
65                  70                  75                  80  


Val Asp Gly Ala Glu Phe Trp Lys Ser Ser Pro Ser Ile Leu Ala Val 
                85                  90                  95      


Gln Arg Ser Ala Ile Leu Lys Lys Gln Gln Gln Gln Gln Gln Gln Gln 
            100                 105                 110         


Gln His Gln Ala Ser Ser Asn Ser Gly Ser Glu Glu Asp Ser Ser Ser 
        115                 120                 125             


Ser Glu Asp Ser Asp Asp Ser Ser Ser Glu Val Lys Arg Lys Lys His 
    130                 135                 140                 


Lys Asp Glu Asp Trp Gln Met Ser Gly Ser Gly Ser Pro Ser Gln Ser 
145                 150                 155                 160 


Gly Ser Asp Ser Glu Ser Glu Glu Glu Arg Glu Lys Ser Ser Cys Asp 
                165                 170                 175     


Glu Xaa Glu Ser Asp Tyr Glu Pro Lys Asn Lys Val Lys Ser Arg Lys 
            180                 185                 190         


Pro Gln Asn Arg Ser Lys Ser Lys Asn Gly Lys Lys Ile Leu Gly Gln 
        195                 200                 205             


Lys Lys Arg Gln Ile Asp Ser Ser Glu Glu Asp Asp Asp Glu Glu Asp 
    210                 215                 220                 


Tyr Asp Asn Asp Lys Arg Ser Ser Arg Arg Gln Ala Xaa Val Asn Val 
225                 230                 235                 240 


Ser Tyr Lys Glu Asp Glu Glu Met Lys Xaa Asp Ser Asp Asp Leu Leu 
                245                 250                 255     


Glu Val Cys Gly Glu Asp Val Pro Gln Pro Glu Glu Glu Glu Phe Glu 
            260                 265                 270         


Xaa Ile Glu Arg Phe Met Asp Cys Arg Ile Gly Arg Lys Gly Ala Xaa 
        275                 280                 285             


Gly Ala Xaa Xaa Xaa Ile Tyr Ala Val Glu Ala Asp Gly Asp Pro Asn 
    290                 295                 300                 


Ala Gly Phe Glu Lys Asn Lys Glu Pro Gly Glu Ile Gln Tyr Leu Ile 
305                 310                 315                 320 


Lys Trp Lys Gly Trp Ser His Ile His Asn Xaa Trp Glu Xaa Glu Glu 
                325                 330                 335     


Xaa Leu Lys Gln Gln Asn Val Arg Gly Met Lys Lys Leu Asp Asn Tyr 
            340                 345                 350         


Lys Lys Lys Asp Gln Glu Xaa Lys Arg Trp Leu Lys Asn Ala Ser Pro 
        355                 360                 365             


Glu Asp Val Glu Tyr Tyr Asn Cys Gln Gln Glu Leu Xaa Asp Asp Leu 
    370                 375                 380                 


His Lys Gln Tyr Gln Ile Val Glu Arg Ile Ile Ala His Ser Asn Gln 
385                 390                 395                 400 


Lys Ser Ala Ala Gly Tyr Pro Asp Tyr Tyr Cys Lys Trp Gln Gly Leu 
                405                 410                 415     


Pro Tyr Ser Glu Cys Ser Trp Glu Asp Gly Ala Leu Ile Ser Lys Lys 
            420                 425                 430         


Phe Gln Ala Cys Ile Asp Glu Tyr Phe Ser Arg Asn Gln Ser Lys Xaa 
        435                 440                 445             


Xaa Pro Phe Lys Asp Cys Lys Val Leu Lys Gln Arg Pro Arg Phe Val 
    450                 455                 460                 


Ala Leu Lys Lys Gln Pro Ser Tyr Ile Gly Gly His Glu Gly Leu Glu 
465                 470                 475                 480 


Leu Arg Asp Tyr Gln Leu Asn Gly Leu Asn Trp Leu Ala His Ser Trp 
                485                 490                 495     


Cys Lys Gly Asn Ser Cys Ile Leu Ala Asp Glu Met Gly Leu Gly Lys 
            500                 505                 510         


Xaa Ile Gln Xaa Ile Ser Phe Leu Asn Tyr Leu Phe His Glu His Gln 
        515                 520                 525             


Leu Tyr Gly Pro Phe Leu Leu Val Val Pro Leu Ser Xaa Leu Xaa Ser 
    530                 535                 540                 


Trp Gln Arg Glu Ile Gln Xaa Trp Ala Ser Gln Met Asn Ala Val Val 
545                 550                 555                 560 


Tyr Leu Gly Asp Ile Asn Ser Arg Asn Met Ile Arg Xaa His Glu Trp 
                565                 570                 575     


Xaa His His Gln Xaa Lys Arg Leu Lys Phe Asn Ile Leu Leu Xaa Xaa 
            580                 585                 590         


Tyr Glu Ile Leu Leu Lys Asp Lys Ala Phe Leu Gly Gly Leu Asn Trp 
        595                 600                 605             


Ala Phe Ile Gly Val Asp Glu Ala His Arg Leu Lys Asn Asp Asp Ser 
    610                 615                 620                 


Leu Leu Tyr Lys Xaa Leu Ile Asp Phe Lys Ser Asn His Arg Leu Leu 
625                 630                 635                 640 


Ile Xaa Gly Xaa Pro Leu Gln Asn Ser Leu Lys Glu Leu Trp Ser Leu 
                645                 650                 655     


Leu His Phe Ile Met Pro Glu Lys Phe Ser Ser Trp Glu Asp Phe Glu 
            660                 665                 670         


Glu Glu His Gly Lys Gly Arg Glu Tyr Gly Tyr Ala Ser Leu His Lys 
        675                 680                 685             


Glu Leu Glu Pro Phe Leu Leu Arg Arg Val Lys Lys Asp Val Glu Lys 
    690                 695                 700                 


Ser Leu Pro Ala Lys Val Glu Gln Ile Leu Arg Met Glu Met Ser Ala 
705                 710                 715                 720 


Leu Gln Lys Gln Tyr Tyr Lys Trp Ile Leu Xaa Arg Asn Tyr Lys Ala 
                725                 730                 735     


Leu Ser Lys Gly Ser Lys Gly Ser Xaa Ser Gly Phe Leu Asn Ile Met 
            740                 745                 750         


Met Glu Leu Lys Lys Cys Cys Asn His Cys Tyr Leu Ile Lys Pro Pro 
        755                 760                 765             


Asp Asn Asn Glu Phe Tyr Asn Lys Gln Glu Ala Leu Gln His Leu Ile 
    770                 775                 780                 


Arg Ser Ser Gly Lys Leu Ile Leu Leu Asp Lys Leu Leu Ile Arg Leu 
785                 790                 795                 800 


Arg Glu Arg Gly Asn Arg Val Leu Ile Phe Ser Gln Met Val Arg Met 
                805                 810                 815     


Leu Asp Ile Leu Ala Glu Tyr Leu Lys Tyr Arg Gln Phe Pro Phe Gln 
            820                 825                 830         


Arg Leu Asp Gly Ser Ile Lys Gly Glu Leu Arg Lys Gln Ala Leu Asp 
        835                 840                 845             


His Phe Asn Ala Glu Gly Ser Glu Asp Phe Cys Phe Leu Leu Ser Xaa 
    850                 855                 860                 


Arg Ala Gly Gly Leu Gly Ile Asn Leu Ala Ser Ala Asp Xaa Val Val 
865                 870                 875                 880 


Ile Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu Gln Ala Gln Ala 
                885                 890                 895     


Arg Ala His Arg Ile Gly Gln Lys Lys Gln Val Asn Ile Tyr Arg Leu 
            900                 905                 910         


Val Xaa Lys Gly Ser Val Glu Glu Asp Ile Leu Glu Arg Ala Lys Lys 
        915                 920                 925             


Lys Met Val Leu Asp His Leu Val Ile Gln Arg Met Asp Xaa Xaa Gly 
    930                 935                 940                 


Lys Xaa Val Leu His Xaa Gly Ser Ala Pro Ser Ser Ser Xaa Pro Phe 
945                 950                 955                 960 


Asn Lys Glu Glu Leu Ser Ala Ile Leu Lys Phe Gly Ala Glu Glu Leu 
                965                 970                 975     


Phe Lys Glu Pro Glu Gly Glu Glu Gln Glu Pro Gln Glu Met Asp Ile 
            980                 985                 990         


Asp Glu Ile Leu Lys Arg Ala Glu  Xaa His Glu Asn Glu  Pro Gly Pro 
        995                 1000                 1005             


Leu Xaa  Val Gly Asp Glu Leu  Leu Ser Gln Phe Lys  Val Ala Asn 
    1010                 1015                 1020             


Phe Ser  Asn Met Asp Glu Asp  Asp Ile Glu Leu Glu  Pro Glu Arg 
    1025                 1030                 1035             


Asn Ser  Lys Asn Trp Glu Glu  Ile Ile Pro Glu Asp  Gln Arg Arg 
    1040                 1045                 1050             


Arg Leu  Glu Glu Glu Glu Arg  Gln Lys Glu Leu Glu  Glu Ile Tyr 
    1055                 1060                 1065             


Met Leu  Pro Arg Met Arg Asn  Cys Ala Lys Gln Ile  Ser Phe Asn 
    1070                 1075                 1080             


Gly Ser  Glu Gly Arg Arg Ser  Arg Ser Arg Arg Tyr  Ser Gly Ser 
    1085                 1090                 1095             


Asp Ser  Asp Ser Ile Ser Glu  Gly Lys Arg Pro Lys  Lys Arg Gly 
    1100                 1105                 1110             


Arg Pro  Arg Xaa Ile Pro Arg  Glu Asn Ile Lys Gly  Phe Ser Asp 
    1115                 1120                 1125             


Ala Glu  Ile Arg Arg Phe Ile  Lys Ser Tyr Lys Lys  Phe Gly Gly 
    1130                 1135                 1140             


Pro Leu  Glu Arg Leu Asp Ala  Ile Ala Arg Asp Ala  Glu Leu Val 
    1145                 1150                 1155             


Asp Lys  Ser Glu Xaa Asp Leu  Arg Arg Leu Gly Glu  Leu Val His 
    1160                 1165                 1170             


Asn Gly  Cys Ile Lys Ala Leu  Lys Asp Ser Ser Ser  Gly Xaa Glu 
    1175                 1180                 1185             


Arg Xaa  Gly Gly Arg Leu Gly  Lys Val Lys Gly Pro  Xaa Phe Arg 
    1190                 1195                 1200             


Ile Ser  Gly Val Gln Val Asn  Ala Lys Leu Val Ile  Ser His Glu 
    1205                 1210                 1215             


Glu Glu  Leu Ile Pro Leu His  Lys Ser Ile Pro Ser  Asp Pro Glu 
    1220                 1225                 1230             


Glu Arg  Lys Gln Tyr Xaa Ile  Pro Cys His Xaa Lys  Ala Ala His 
    1235                 1240                 1245             


Phe Asp  Ile Asp Trp Gly Lys  Glu Asp Asp Ser Asn  Leu Leu Ile 
    1250                 1255                 1260             


Gly Ile  Tyr Glu Tyr Gly Tyr  Gly Ser Trp Glu Met  Ile Lys Met 
    1265                 1270                 1275             


Asp Pro  Asp Leu Ser Leu Xaa  His Lys Ile Leu Pro  Asp Asp Pro 
    1280                 1285                 1290             


Asp Lys  Lys Pro Gln Ala Lys  Gln Leu Gln Xaa Arg  Ala Asp Tyr 
    1295                 1300                 1305             


Leu Ile  Lys Leu Leu Ser Arg  Asp Leu Ala Lys Lys  Glu Ala Leu 
    1310                 1315                 1320             


Ser Gly  Ala Gly Ser Ser Lys  Arg Arg Lys Ala Arg  Ala Lys Lys 
    1325                 1330                 1335             


Asn Lys  Ala Met Lys Ser Ile  Lys Val Lys Glu Glu  Ile Lys Ser 
    1340                 1345                 1350             


Asp Ser  Ser Pro Leu Pro Ser  Glu Lys Ser Asp Glu  Asp Asp Asp 
    1355                 1360                 1365             


Lys Leu  Ser Glu Ser Lys Ser  Asp Gly Arg Glu Arg  Ser Lys Lys 
    1370                 1375                 1380             


Ser Ser  Val Ser Asp Ala Pro  Val His Ile Xaa Ala  Ser Gly Glu 
    1385                 1390                 1395             


Pro Val  Pro Ile Ser Glu Glu  Ser Glu Glu Leu Asp  Gln Lys Xaa 
    1400                 1405                 1410             


Phe Ser  Ile Cys Lys Glu Arg  Met Arg Pro Val Lys  Ala Ala Leu 
    1415                 1420                 1425             


Lys Gln  Leu Asp Arg Pro Glu  Lys Gly Leu Ser Glu  Arg Glu Gln 
    1430                 1435                 1440             


Leu Glu  His Xaa Arg Gln Cys  Leu Ile Lys Ile Gly  Asp His Ile 
    1445                 1450                 1455             


Xaa Glu  Cys Leu Lys Glu Tyr  Xaa Asn Pro Glu Gln  Ile Lys Gln 
    1460                 1465                 1470             


Trp Arg  Lys Asn Leu Trp Ile  Phe Val Ser Lys Phe  Xaa Glu Phe 
    1475                 1480                 1485             


Asp Ala  Arg Lys Leu His Lys  Leu Tyr Lys His Ala  Ile Lys Lys 
    1490                 1495                 1500             


Arg Gln  Glu Ser Gln Gln Asn  Ser Asp Gln Asn Ser  Asn Leu Asn 
    1505                 1510                 1515             


Pro His  Val Ile Arg Asn Pro  Asp Val Glu Arg Leu  Lys Glu Asn 
    1520                 1525                 1530             


Xaa Asn  His Asp Asp Ser Ser  Arg Asp Ser Tyr Ser  Ser Asp Arg 
    1535                 1540                 1545             


His Leu  Xaa Gln Tyr His Asp  His His Lys Asp Arg  His Gln Gly 
    1550                 1555                 1560             


Asp Ser  Tyr Lys Lys Ser Asp  Ser Arg Lys Arg Pro  Tyr Ser Ser 
    1565                 1570                 1575             


Phe Ser  Asn Gly Lys Asp His  Arg Asp Trp Asp His  Tyr Lys Gln 
    1580                 1585                 1590             


Asp Ser  Arg Tyr Tyr Ser Asp  Arg Glu Lys His Arg  Lys Leu Asp 
    1595                 1600                 1605             


Asp His  Arg Ser Arg Asp His  Arg Ser Asn Leu Glu  Gly Ser Leu 
    1610                 1615                 1620             


Lys Asp  Arg Ser His Ser Asp  His Arg Ser His Ser  Asp His Arg 
    1625                 1630                 1635             


Leu His  Ser Asp His Arg Ser  Ser Ser Glu Tyr Xaa  His His Lys 
    1640                 1645                 1650             


Ser Ser  Arg Asp Tyr Arg Tyr  His Ser Asp Trp Gln  Met Asp His 
    1655                 1660                 1665             


Arg Ala  Ser Ser Ser Gly Pro  Arg Ser Pro Leu Asp  Gln Arg Ser 
    1670                 1675                 1680             


Pro Tyr  Gly Ser Arg Ser Pro  Phe Glu His Ser Val  Glu His Lys 
    1685                 1690                 1695             


Ser Xaa  Pro Glu His Xaa Trp  Ser Ser Arg Lys Xaa  
    1700                 1705                 1710 


<210> 5957
<211> 272
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<400> 5957
Xaa Pro Asp Lys Lys Pro Gln Ala Lys Gln Leu Gln Xaa Arg Ala Asp 
1               5                   10                  15      


Tyr Leu Ile Lys Leu Leu Ser Arg Asp Leu Ala Lys Lys Glu Ala Leu 
            20                  25                  30          


Ser Gly Ala Gly Ser Ser Lys Arg Arg Lys Ala Arg Ala Lys Lys Asn 
        35                  40                  45              


Lys Ala Met Lys Ser Ile Lys Val Lys Glu Glu Ile Lys Ser Asp Ser 
    50                  55                  60                  


Ser Pro Leu Pro Ser Glu Lys Ser Asp Glu Asp Asp Asp Lys Asp Glu 
65                  70                  75                  80  


Ile Ser Ser Val Lys His Pro Asn Lys Lys Ile Lys Xaa Glu Arg Asp 
                85                  90                  95      


Ser Glu Glu Lys Pro Glu Pro Asp Val Tyr Ile Lys Lys Glu Pro Glu 
            100                 105                 110         


Glu Lys Arg Glu Ala Lys Glu Lys Glu Asn Lys Lys Glu Leu Lys Arg 
        115                 120                 125             


Glu Ile Lys Glu Lys Glu Asp Lys Lys Asp Ile Lys Glu Lys Asp Phe 
    130                 135                 140                 


Lys Glu Lys Arg Glu Asn Lys Val Lys Glu Ala Ile Gln Lys Glu Lys 
145                 150                 155                 160 


Asp Ile Lys Glu Glu Lys Leu Ser Glu Ser Lys Ser Asp Gly Arg Glu 
                165                 170                 175     


Arg Ser Lys Lys Ser Ser Val Ser Asp Ala Pro Val His Ile Xaa Ala 
            180                 185                 190         


Ser Gly Glu Pro Val Pro Ile Ser Glu Glu Ser Glu Glu Leu Asp Gln 
        195                 200                 205             


Lys Xaa Phe Ser Ile Cys Lys Glu Arg Met Arg Pro Val Lys Ala Ala 
    210                 215                 220                 


Leu Lys Gln Leu Asp Arg Pro Glu Lys Gly Leu Ser Glu Arg Glu Gln 
225                 230                 235                 240 


Leu Glu His Xaa Arg Gln Cys Leu Ile Lys Ile Gly Asp His Ile Xaa 
                245                 250                 255     


Glu Cys Leu Lys Glu Tyr Xaa Asn Pro Glu Gln Ile Lys Gln Trp Arg 
            260                 265                 270         


<210> 5958
<211> 797
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<400> 5958
Met Ala Val Ser Trp Glu Met Arg Trp Ala Trp Gly Arg Pro Ala Arg 
1               5                   10                  15      


Phe Ala Pro Gly Leu Ser Cys Val Xaa Tyr Ala Gly Asp Lys Glu Glu 
            20                  25                  30          


Arg Ala Cys Leu Gln Gln Asp Leu Lys Gln Glu Ser Arg Phe His Val 
        35                  40                  45              


Leu Leu Xaa Xaa Tyr Glu Ile Cys Leu Lys Asp Ala Ser Phe Leu Lys 
    50                  55                  60                  


Ser Phe Pro Trp Ser Val Leu Val Val Asp Glu Ala His Arg Leu Lys 
65                  70                  75                  80  


Asn Gln Ser Ser Leu Leu His Lys Xaa Leu Ser Glu Phe Ser Val Val 
                85                  90                  95      


Phe Ser Leu Leu Leu Xaa Gly Xaa Pro Ile Gln Asn Ser Leu Gln Glu 
            100                 105                 110         


Leu Tyr Ser Leu Leu Ser Phe Val Glu Pro Asp Leu Phe Ser Lys Glu 
        115                 120                 125             


Glu Val Gly Asp Phe Ile Gln Arg Tyr Gln Asp Ile Glu Lys Glu Ser 
    130                 135                 140                 


Glu Ser Ala Ser Glu Leu His Lys Leu Leu Gln Pro Phe Leu Leu Arg 
145                 150                 155                 160 


Arg Val Lys Ala Glu Val Ala Xaa Glu Leu Pro Lys Lys Xaa Glu Val 
                165                 170                 175     


Val Ile Tyr His Gly Met Ser Ala Leu Gln Lys Lys Tyr Tyr Lys Ala 
            180                 185                 190         


Ile Leu Met Lys Asp Leu Asp Ala Phe Glu Asn Glu Xaa Ala Lys Lys 
        195                 200                 205             


Val Lys Leu Gln Asn Ile Leu Ser Gln Leu Arg Lys Cys Val Asp His 
    210                 215                 220                 


Pro Tyr Leu Phe Asp Gly Val Glu Pro Glu Pro Phe Glu Val Gly Asp 
225                 230                 235                 240 


His Leu Xaa Glu Ala Ser Gly Lys Leu His Leu Leu Asp Lys Leu Leu 
                245                 250                 255     


Ala Phe Leu Tyr Ser Gly Gly His Arg Val Leu Leu Phe Ser Gln Met 
            260                 265                 270         


Xaa Gln Met Leu Asp Ile Leu Gln Asp Tyr Met Asp Tyr Arg Gly Tyr 
        275                 280                 285             


Ser Tyr Glu Arg Val Asp Gly Ser Val Arg Gly Glu Glu Arg His Leu 
    290                 295                 300                 


Ala Ile Lys Asn Phe Gly Gln Gln Pro Ile Phe Val Phe Leu Leu Ser 
305                 310                 315                 320 


Xaa Arg Ala Gly Gly Val Gly Met Asn Leu Xaa Ala Ala Asp Xaa Val 
                325                 330                 335     


Ile Phe Val Asp Ser Asp Phe Asn Pro Gln Asn Asp Leu Gln Ala Ala 
            340                 345                 350         


Ala Arg Ala His Arg Ile Gly Gln Asn Lys Ser Val Lys Val Ile Arg 
        355                 360                 365             


Leu Ile Gly Arg Asp Xaa Val Glu Glu Ile Val Tyr Arg Lys Ala Ala 
    370                 375                 380                 


Ser Lys Leu Gln Leu Xaa Asn Met Ile Ile Glu Gly Gly His Phe Xaa 
385                 390                 395                 400 


Leu Gly Ala Gln Lys Pro Ala Ala Asp Ala Asp Leu Gln Leu Ser Glu 
                405                 410                 415     


Ile Leu Lys Phe Gly Leu Asp Lys Leu Leu Ala Ser Glu Gly Ser Xaa 
            420                 425                 430         


Met Asp Glu Ile Asp Leu Glu Ser Ile Leu Gly Glu Xaa Lys Asp Gly 
        435                 440                 445             


Gln Trp Val Ser Asp Ala Leu Pro Ala Ala Glu Gly Gly Ser Arg Asp 
    450                 455                 460                 


Gln Glu Glu Gly Lys Asn His Met Tyr Leu Phe Glu Gly Lys Asp Tyr 
465                 470                 475                 480 


Ser Lys Glu Pro Ser Lys Glu Asp Arg Lys Ser Phe Glu Gln Leu Val 
                485                 490                 495     


Asn Leu Gln Lys Xaa Leu Leu Glu Lys Ala Ser Gln Glu Gly Arg Ser 
            500                 505                 510         


Leu Arg Asn Lys Gly Ser Val Leu Ile Pro Gly Leu Val Glu Gly Ser 
        515                 520                 525             


Xaa Lys Arg Lys Arg Val Leu Ser Pro Glu Glu Leu Glu Asp Arg Gln 
    530                 535                 540                 


Lys Lys Arg Gln Glu Ala Ala Ala Lys Arg Arg Arg Leu Ile Glu Glu 
545                 550                 555                 560 


Lys Lys Arg Gln Lys Glu Glu Ala Glu His Lys Lys Lys Met Ala Trp 
                565                 570                 575     


Trp Glu Ser Asn Asn Tyr Gln Ser Phe Cys Leu Pro Ser Glu Glu Ser 
            580                 585                 590         


Glu Pro Glu Asp Leu Glu Asn Gly Glu Glu Ser Ser Ala Glu Leu Asp 
        595                 600                 605             


Tyr Gln Asp Pro Asp Ala Xaa Ser Leu Lys Tyr Val Ser Gly Asp Val 
    610                 615                 620                 


Xaa His Pro Gln Ala Gly Ala Glu Asp Ala Leu Ile Val His Cys Val 
625                 630                 635                 640 


Asp Asp Ser Gly His Trp Gly Arg Gly Gly Leu Phe Xaa Ala Leu Glu 
                645                 650                 655     


Lys Arg Ser Ala Glu Pro Arg Lys Ile Tyr Glu Leu Ala Gly Lys Met 
            660                 665                 670         


Lys Asp Leu Ser Leu Gly Gly Val Leu Leu Phe Pro Val Asp Asp Lys 
        675                 680                 685             


Glu Ser Arg Asn Lys Gly Gln Asp Leu Leu Ala Leu Ile Val Ala Gln 
    690                 695                 700                 


His Arg Asp Arg Ser Asn Val Leu Ser Gly Ile Lys Met Ala Ala Leu 
705                 710                 715                 720 


Glu Glu Gly Leu Lys Lys Ile Phe Leu Ala Ala Lys Lys Lys Lys Ala 
                725                 730                 735     


Ser Val His Leu Pro Arg Ile Gly His Ala Xaa Lys Gly Phe Asn Trp 
            740                 745                 750         


Tyr Gly Xaa Glu Arg Leu Ile Arg Lys His Leu Ala Ala Arg Gly Ile 
        755                 760                 765             


Pro Xaa Tyr Ile Tyr Tyr Phe Pro Arg Ser Lys Ser Ala Val Leu His 
    770                 775                 780                 


Ser Gln Ser Ser Ser Ser Ser Ser Arg Gln Leu Val Pro 
785                 790                 795         


<210> 5959
<211> 693
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<400> 5959
Met Glu Arg Ala Gly Ala Xaa Ser Arg Gly Gly Gln Ala Pro Gly Phe 
1               5                   10                  15      


Leu Leu Arg Leu His Xaa Glu Gly Arg Ala Glu Ala Ala Arg Val Gln 
            20                  25                  30          


Glu Gln Asp Leu Arg Gln Trp Gly Leu Xaa Ala Ser Glu Leu His Lys 
        35                  40                  45              


Leu Leu Gln Pro Phe Leu Leu Arg Arg Val Lys Ala Glu Val Ala Xaa 
    50                  55                  60                  


Glu Leu Pro Lys Lys Xaa Glu Val Val Ile Tyr His Gly Met Ser Ala 
65                  70                  75                  80  


Leu Gln Lys Lys Tyr Tyr Lys Ala Ile Leu Met Lys Asp Leu Asp Ala 
                85                  90                  95      


Phe Glu Asn Glu Xaa Ala Lys Lys Val Lys Leu Gln Asn Ile Leu Ser 
            100                 105                 110         


Gln Leu Arg Lys Cys Val Asp His Pro Tyr Leu Phe Asp Gly Val Glu 
        115                 120                 125             


Pro Glu Pro Phe Glu Val Gly Asp His Leu Xaa Glu Ala Ser Gly Lys 
    130                 135                 140                 


Leu His Leu Leu Asp Lys Leu Leu Ala Phe Leu Tyr Ser Gly Gly His 
145                 150                 155                 160 


Arg Val Leu Leu Phe Ser Gln Met Xaa Gln Met Leu Asp Ile Leu Gln 
                165                 170                 175     


Asp Tyr Met Asp Tyr Arg Gly Tyr Ser Tyr Glu Arg Val Asp Gly Ser 
            180                 185                 190         


Val Arg Gly Glu Glu Arg His Leu Ala Ile Lys Asn Phe Gly Gln Gln 
        195                 200                 205             


Pro Ile Phe Val Phe Leu Leu Ser Xaa Arg Ala Gly Gly Val Gly Met 
    210                 215                 220                 


Asn Leu Xaa Ala Ala Asp Xaa Val Ile Phe Val Asp Ser Asp Phe Asn 
225                 230                 235                 240 


Pro Gln Asn Asp Leu Gln Ala Ala Ala Arg Ala His Arg Ile Gly Gln 
                245                 250                 255     


Asn Lys Ser Val Lys Val Ile Arg Leu Ile Gly Arg Asp Xaa Val Glu 
            260                 265                 270         


Glu Ile Val Tyr Arg Lys Ala Ala Ser Lys Leu Gln Leu Xaa Asn Met 
        275                 280                 285             


Ile Ile Glu Gly Gly His Phe Xaa Leu Gly Ala Gln Lys Pro Ala Ala 
    290                 295                 300                 


Asp Ala Asp Leu Gln Leu Ser Glu Ile Leu Lys Phe Gly Leu Asp Lys 
305                 310                 315                 320 


Leu Leu Ala Ser Glu Gly Ser Xaa Met Asp Glu Ile Asp Leu Glu Ser 
                325                 330                 335     


Ile Leu Gly Glu Xaa Lys Asp Gly Gln Trp Val Ser Asp Ala Leu Pro 
            340                 345                 350         


Ala Ala Glu Gly Gly Ser Arg Asp Gln Glu Glu Gly Lys Asn His Met 
        355                 360                 365             


Tyr Leu Phe Glu Gly Lys Asp Tyr Ser Lys Glu Pro Ser Lys Glu Asp 
    370                 375                 380                 


Arg Lys Ser Phe Glu Gln Leu Val Asn Leu Gln Lys Xaa Leu Leu Glu 
385                 390                 395                 400 


Lys Ala Ser Gln Glu Gly Arg Ser Leu Arg Asn Lys Gly Ser Val Leu 
                405                 410                 415     


Ile Pro Gly Leu Val Glu Gly Ser Xaa Lys Arg Lys Arg Val Leu Ser 
            420                 425                 430         


Pro Glu Glu Leu Glu Asp Arg Gln Lys Lys Arg Gln Glu Ala Ala Ala 
        435                 440                 445             


Lys Arg Arg Arg Leu Ile Glu Glu Lys Lys Arg Gln Lys Glu Glu Ala 
    450                 455                 460                 


Glu His Lys Lys Lys Met Ala Trp Trp Glu Ser Asn Asn Tyr Gln Ser 
465                 470                 475                 480 


Phe Cys Leu Pro Ser Glu Glu Ser Glu Pro Glu Asp Leu Glu Asn Gly 
                485                 490                 495     


Glu Glu Ser Ser Ala Glu Leu Asp Tyr Gln Asp Pro Asp Ala Xaa Ser 
            500                 505                 510         


Leu Lys Tyr Val Ser Gly Asp Val Xaa His Pro Gln Ala Gly Ala Glu 
        515                 520                 525             


Asp Ala Leu Ile Val His Cys Val Asp Asp Ser Gly His Trp Gly Arg 
    530                 535                 540                 


Gly Gly Leu Phe Xaa Ala Leu Glu Lys Arg Ser Ala Glu Pro Arg Lys 
545                 550                 555                 560 


Ile Tyr Glu Leu Ala Gly Lys Met Lys Asp Leu Ser Leu Gly Gly Val 
                565                 570                 575     


Leu Leu Phe Pro Val Asp Asp Lys Glu Ser Arg Asn Lys Gly Gln Asp 
            580                 585                 590         


Leu Leu Ala Leu Ile Val Ala Gln His Arg Asp Arg Ser Asn Val Leu 
        595                 600                 605             


Ser Gly Ile Lys Met Ala Ala Leu Glu Glu Gly Leu Lys Lys Ile Phe 
    610                 615                 620                 


Leu Ala Ala Lys Lys Lys Lys Ala Ser Val His Leu Pro Arg Ile Gly 
625                 630                 635                 640 


His Ala Xaa Lys Gly Phe Asn Trp Tyr Gly Xaa Glu Arg Leu Ile Arg 
                645                 650                 655     


Lys His Leu Ala Ala Arg Gly Ile Pro Xaa Tyr Ile Tyr Tyr Phe Pro 
            660                 665                 670         


Arg Ser Lys Ser Ala Val Leu His Ser Gln Ser Ser Ser Ser Ser Ser 
        675                 680                 685             


Arg Gln Leu Val Pro 
    690             


<210> 5960
<211> 56
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<400> 5960
Met Glu Arg Ala Gly Ala Xaa Ser Arg Gly Gly Gln Ala Pro Gly Phe 
1               5                   10                  15      


Leu Leu Arg Leu His Xaa Glu Gly Arg Ala Glu Ala Ala Arg Val Gln 
            20                  25                  30          


Glu Gln Asp Leu Arg Gln Trp Gly Leu Xaa Asp Ser Leu Gly Val Phe 
        35                  40                  45              


Leu Leu Trp Met Lys Leu Xaa Gly 
    50                  55      


<210> 5961
<211> 82
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 5961
Met Glu Arg Ala Gly Ala Xaa Ser Arg Gly Gly Gln Ala Pro Gly Phe 
1               5                   10                  15      


Leu Leu Arg Leu His Xaa Glu Gly Arg Ala Glu Ala Ala Arg Val Gln 
            20                  25                  30          


Glu Gln Asp Leu Arg Gln Trp Gly Leu Xaa Gly Ile His Leu Arg Ser 
        35                  40                  45              


Tyr Gln Leu Glu Gly Val Asn Trp Leu Ala Gln Arg Phe His Cys Gln 
    50                  55                  60                  


Asn Gly Cys Ile Leu Gly Asp Glu Met Gly Leu Gly Lys Xaa Cys Gln 
65                  70                  75                  80  


Glu Asp 
        


<210> 5962
<211> 377
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<400> 5962
Met Glu Arg Ala Gly Ala Xaa Ser Arg Gly Gly Gln Ala Pro Gly Phe 
1               5                   10                  15      


Leu Leu Arg Leu His Xaa Glu Gly Arg Ala Glu Ala Ala Arg Val Gln 
            20                  25                  30          


Glu Gln Asp Leu Arg Gln Trp Gly Leu Xaa Gly Ile His Leu Arg Ser 
        35                  40                  45              


Tyr Gln Leu Glu Gly Val Asn Trp Leu Ala Gln Arg Phe His Cys Gln 
    50                  55                  60                  


Asn Gly Cys Ile Leu Gly Asp Glu Met Gly Leu Gly Lys Xaa Cys Gln 
65                  70                  75                  80  


Xaa Ile Ala Leu Phe Ile Tyr Leu Ala Gly Arg Leu Asn Asp Glu Gly 
                85                  90                  95      


Pro Phe Leu Ile Leu Cys Pro Leu Ser Val Leu Ser Asn Trp Lys Glu 
            100                 105                 110         


Glu Met Gln Arg Phe Ala Pro Gly Leu Ser Cys Val Xaa Tyr Ala Gly 
        115                 120                 125             


Asp Lys Glu Glu Arg Ala Cys Leu Gln Gln Asp Leu Lys Gln Glu Ser 
    130                 135                 140                 


Arg Phe His Val Leu Leu Xaa Xaa Tyr Glu Ile Cys Leu Lys Asp Ala 
145                 150                 155                 160 


Ser Phe Leu Lys Ser Phe Pro Trp Ser Val Leu Val Val Asp Glu Ala 
                165                 170                 175     


His Arg Leu Lys Asn Gln Ser Ser Leu Leu His Lys Xaa Leu Ser Glu 
            180                 185                 190         


Phe Ser Val Val Phe Ser Leu Leu Leu Xaa Gly Xaa Pro Ile Gln Asn 
        195                 200                 205             


Ser Leu Gln Glu Leu Tyr Ser Leu Leu Ser Phe Val Glu Pro Asp Leu 
    210                 215                 220                 


Phe Ser Lys Glu Glu Val Gly Asp Phe Ile Gln Arg Tyr Gln Asp Ile 
225                 230                 235                 240 


Glu Lys Glu Ser Glu Ser Ala Ser Glu Leu His Lys Leu Leu Gln Pro 
                245                 250                 255     


Phe Leu Leu Arg Arg Val Lys Ala Glu Val Ala Xaa Glu Leu Pro Lys 
            260                 265                 270         


Lys Xaa Glu Val Val Ile Tyr His Gly Met Ser Ala Leu Gln Lys Lys 
        275                 280                 285             


Tyr Tyr Lys Ala Ile Leu Met Lys Asp Leu Asp Ala Phe Glu Asn Glu 
    290                 295                 300                 


Xaa Ala Lys Lys Val Lys Leu Gln Asn Ile Leu Ser Gln Leu Arg Lys 
305                 310                 315                 320 


Cys Val Asp His Pro Tyr Leu Phe Asp Gly Val Glu Pro Glu Pro Phe 
                325                 330                 335     


Glu Val Gly Asp His Leu Xaa Glu Ala Ser Gly Lys Leu His Leu Leu 
            340                 345                 350         


Asp Lys Leu Leu Ala Phe Leu Tyr Ser Gly Trp Ser Trp His Glu Leu 
        355                 360                 365             


Asn Ser Ser Arg Tyr Cys Asp Phe Cys 
    370                 375         


<210> 5963
<211> 897
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<400> 5963
Met Glu Arg Ala Gly Ala Xaa Ser Arg Gly Gly Gln Ala Pro Gly Phe 
1               5                   10                  15      


Leu Leu Arg Leu His Xaa Glu Gly Arg Ala Glu Ala Ala Arg Val Gln 
            20                  25                  30          


Glu Gln Asp Leu Arg Gln Trp Gly Leu Xaa Gly Ile His Leu Arg Ser 
        35                  40                  45              


Tyr Gln Leu Glu Gly Val Asn Trp Leu Ala Gln Arg Phe His Cys Gln 
    50                  55                  60                  


Asn Gly Cys Ile Leu Gly Asp Glu Met Gly Leu Gly Lys Xaa Cys Gln 
65                  70                  75                  80  


Xaa Ile Ala Leu Phe Ile Tyr Leu Ala Gly Arg Leu Asn Asp Glu Gly 
                85                  90                  95      


Pro Phe Leu Ile Leu Cys Pro Leu Ser Val Leu Ser Asn Trp Lys Glu 
            100                 105                 110         


Glu Met Gln Arg Phe Ala Pro Gly Leu Ser Cys Val Xaa Tyr Ala Gly 
        115                 120                 125             


Asp Lys Glu Glu Arg Ala Cys Leu Gln Gln Asp Leu Lys Gln Glu Ser 
    130                 135                 140                 


Arg Phe His Val Leu Leu Xaa Xaa Tyr Glu Ile Cys Leu Lys Asp Ala 
145                 150                 155                 160 


Ser Phe Leu Lys Ser Phe Pro Trp Ser Val Leu Val Val Asp Glu Ala 
                165                 170                 175     


His Arg Leu Lys Asn Gln Ser Ser Leu Leu His Lys Xaa Leu Ser Glu 
            180                 185                 190         


Phe Ser Val Val Phe Ser Leu Leu Leu Xaa Gly Xaa Pro Ile Gln Asn 
        195                 200                 205             


Ser Leu Gln Glu Leu Tyr Ser Leu Leu Ser Phe Val Glu Pro Asp Leu 
    210                 215                 220                 


Phe Ser Lys Glu Glu Val Gly Asp Phe Ile Gln Arg Tyr Gln Asp Ile 
225                 230                 235                 240 


Glu Lys Glu Ser Glu Ser Ala Ser Glu Leu His Lys Leu Leu Gln Pro 
                245                 250                 255     


Phe Leu Leu Arg Arg Val Lys Ala Glu Val Ala Xaa Glu Leu Pro Lys 
            260                 265                 270         


Lys Xaa Glu Val Val Ile Tyr His Gly Met Ser Ala Leu Gln Lys Lys 
        275                 280                 285             


Tyr Tyr Lys Ala Ile Leu Met Lys Asp Leu Asp Ala Phe Glu Asn Glu 
    290                 295                 300                 


Xaa Ala Lys Lys Val Lys Leu Gln Asn Ile Leu Ser Gln Leu Arg Lys 
305                 310                 315                 320 


Cys Val Asp His Pro Tyr Leu Phe Asp Gly Val Glu Pro Glu Pro Phe 
                325                 330                 335     


Glu Val Gly Asp His Leu Xaa Glu Ala Ser Gly Lys Leu His Leu Leu 
            340                 345                 350         


Asp Lys Leu Leu Ala Phe Leu Tyr Ser Gly Gly His Arg Val Leu Leu 
        355                 360                 365             


Phe Ser Gln Met Xaa Gln Met Leu Asp Ile Leu Gln Asp Tyr Met Asp 
    370                 375                 380                 


Tyr Arg Gly Tyr Ser Tyr Glu Arg Val Asp Gly Ser Val Arg Gly Glu 
385                 390                 395                 400 


Glu Arg His Leu Ala Ile Lys Asn Phe Gly Gln Gln Pro Ile Phe Val 
                405                 410                 415     


Phe Leu Leu Ser Xaa Arg Ala Gly Gly Val Gly Met Asn Leu Xaa Ala 
            420                 425                 430         


Ala Asp Xaa Val Ile Phe Val Asp Ser Asp Phe Asn Pro Gln Asn Asp 
        435                 440                 445             


Leu Gln Ala Ala Ala Arg Ala His Arg Ile Gly Gln Asn Lys Ser Val 
    450                 455                 460                 


Lys Val Ile Arg Leu Ile Gly Arg Asp Xaa Val Glu Glu Ile Val Tyr 
465                 470                 475                 480 


Arg Lys Ala Ala Ser Lys Leu Gln Leu Xaa Asn Met Ile Ile Glu Gly 
                485                 490                 495     


Gly His Phe Xaa Leu Gly Ala Gln Lys Pro Ala Ala Asp Ala Asp Leu 
            500                 505                 510         


Gln Leu Ser Glu Ile Leu Lys Phe Gly Leu Asp Lys Leu Leu Ala Ser 
        515                 520                 525             


Glu Gly Ser Xaa Met Asp Glu Ile Asp Leu Glu Ser Ile Leu Gly Glu 
    530                 535                 540                 


Xaa Lys Asp Gly Gln Trp Val Ser Asp Ala Leu Pro Ala Ala Glu Gly 
545                 550                 555                 560 


Gly Ser Arg Asp Gln Glu Glu Gly Lys Asn His Met Tyr Leu Phe Glu 
                565                 570                 575     


Gly Lys Asp Tyr Ser Lys Glu Pro Ser Lys Glu Asp Arg Lys Ser Phe 
            580                 585                 590         


Glu Gln Leu Val Asn Leu Gln Lys Xaa Leu Leu Glu Lys Ala Ser Gln 
        595                 600                 605             


Glu Gly Arg Ser Leu Arg Asn Lys Gly Ser Val Leu Ile Pro Gly Leu 
    610                 615                 620                 


Val Glu Gly Ser Xaa Lys Arg Lys Arg Val Leu Ser Pro Glu Glu Leu 
625                 630                 635                 640 


Glu Asp Arg Gln Lys Lys Arg Gln Glu Ala Ala Ala Lys Arg Arg Arg 
                645                 650                 655     


Leu Ile Glu Glu Lys Lys Arg Gln Lys Glu Glu Ala Glu His Lys Lys 
            660                 665                 670         


Lys Met Ala Trp Trp Glu Ser Asn Asn Tyr Gln Ser Phe Cys Leu Pro 
        675                 680                 685             


Ser Glu Glu Ser Glu Pro Glu Asp Leu Glu Asn Gly Glu Glu Ser Ser 
    690                 695                 700                 


Ala Glu Leu Asp Tyr Gln Asp Pro Asp Ala Xaa Ser Leu Lys Tyr Val 
705                 710                 715                 720 


Ser Gly Asp Val Xaa His Pro Gln Ala Gly Ala Glu Asp Ala Leu Ile 
                725                 730                 735     


Val His Cys Val Asp Asp Ser Gly His Trp Gly Arg Gly Gly Leu Phe 
            740                 745                 750         


Xaa Ala Leu Glu Lys Arg Ser Ala Glu Pro Arg Lys Ile Tyr Glu Leu 
        755                 760                 765             


Ala Gly Lys Met Lys Asp Leu Ser Leu Gly Gly Val Leu Leu Phe Pro 
    770                 775                 780                 


Val Asp Asp Lys Glu Ser Arg Asn Lys Gly Gln Asp Leu Leu Ala Leu 
785                 790                 795                 800 


Ile Val Ala Gln His Arg Asp Arg Ser Asn Val Leu Ser Gly Ile Lys 
                805                 810                 815     


Met Ala Ala Leu Glu Glu Gly Leu Lys Lys Ile Phe Leu Ala Ala Lys 
            820                 825                 830         


Lys Lys Lys Ala Ser Val His Leu Pro Arg Ile Gly His Ala Xaa Lys 
        835                 840                 845             


Gly Phe Asn Trp Tyr Gly Xaa Glu Arg Leu Ile Arg Lys His Leu Ala 
    850                 855                 860                 


Ala Arg Gly Ile Pro Xaa Tyr Ile Tyr Tyr Phe Pro Arg Ser Lys Ser 
865                 870                 875                 880 


Ala Val Leu His Ser Gln Ser Ser Ser Ser Ser Ser Arg Gln Leu Val 
                885                 890                 895     


Pro 
    


<210> 5964
<211> 616
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<400> 5964
Met Ser Ala Leu Gln Lys Lys Tyr Tyr Lys Ala Ile Leu Met Lys Asp 
1               5                   10                  15      


Leu Asp Ala Phe Glu Asn Glu Xaa Ala Lys Lys Val Lys Leu Gln Asn 
            20                  25                  30          


Ile Leu Ser Gln Leu Arg Lys Cys Val Asp His Pro Tyr Leu Phe Asp 
        35                  40                  45              


Gly Val Glu Pro Glu Pro Phe Glu Val Gly Asp His Leu Xaa Glu Ala 
    50                  55                  60                  


Ser Gly Lys Leu His Leu Leu Asp Lys Leu Leu Ala Phe Leu Tyr Ser 
65                  70                  75                  80  


Gly Gly His Arg Val Leu Leu Phe Ser Gln Met Xaa Gln Met Leu Asp 
                85                  90                  95      


Ile Leu Gln Asp Tyr Met Asp Tyr Arg Gly Tyr Ser Tyr Glu Arg Val 
            100                 105                 110         


Asp Gly Ser Val Arg Gly Glu Glu Arg His Leu Ala Ile Lys Asn Phe 
        115                 120                 125             


Gly Gln Gln Pro Ile Phe Val Phe Leu Leu Ser Xaa Arg Ala Gly Gly 
    130                 135                 140                 


Val Gly Met Asn Leu Xaa Ala Ala Asp Xaa Val Ile Phe Val Asp Ser 
145                 150                 155                 160 


Asp Phe Asn Pro Gln Asn Asp Leu Gln Ala Ala Ala Arg Ala His Arg 
                165                 170                 175     


Ile Gly Gln Asn Lys Ser Val Lys Val Ile Arg Leu Ile Gly Arg Asp 
            180                 185                 190         


Xaa Val Glu Glu Ile Val Tyr Arg Lys Ala Ala Ser Lys Leu Gln Leu 
        195                 200                 205             


Xaa Asn Met Ile Ile Glu Gly Gly His Phe Xaa Leu Gly Ala Gln Lys 
    210                 215                 220                 


Pro Ala Ala Asp Ala Asp Leu Gln Leu Ser Glu Ile Leu Lys Phe Gly 
225                 230                 235                 240 


Leu Asp Lys Leu Leu Ala Ser Glu Gly Ser Xaa Met Asp Glu Ile Asp 
                245                 250                 255     


Leu Glu Ser Ile Leu Gly Glu Xaa Lys Asp Gly Gln Trp Val Ser Asp 
            260                 265                 270         


Ala Leu Pro Ala Ala Glu Gly Gly Ser Arg Asp Gln Glu Glu Gly Lys 
        275                 280                 285             


Asn His Met Tyr Leu Phe Glu Gly Lys Asp Tyr Ser Lys Glu Pro Ser 
    290                 295                 300                 


Lys Glu Asp Arg Lys Ser Phe Glu Gln Leu Val Asn Leu Gln Lys Xaa 
305                 310                 315                 320 


Leu Leu Glu Lys Ala Ser Gln Glu Gly Arg Ser Leu Arg Asn Lys Gly 
                325                 330                 335     


Ser Val Leu Ile Pro Gly Leu Val Glu Gly Ser Xaa Lys Arg Lys Arg 
            340                 345                 350         


Val Leu Ser Pro Glu Glu Leu Glu Asp Arg Gln Lys Lys Arg Gln Glu 
        355                 360                 365             


Ala Ala Ala Lys Arg Arg Arg Leu Ile Glu Glu Lys Lys Arg Gln Lys 
    370                 375                 380                 


Glu Glu Ala Glu His Lys Lys Lys Met Ala Trp Trp Glu Ser Asn Asn 
385                 390                 395                 400 


Tyr Gln Ser Phe Cys Leu Pro Ser Glu Glu Ser Glu Pro Glu Asp Leu 
                405                 410                 415     


Glu Asn Gly Glu Glu Ser Ser Ala Glu Leu Asp Tyr Gln Asp Pro Asp 
            420                 425                 430         


Ala Xaa Ser Leu Lys Tyr Val Ser Gly Asp Val Xaa His Pro Gln Ala 
        435                 440                 445             


Gly Ala Glu Asp Ala Leu Ile Val His Cys Val Asp Asp Ser Gly His 
    450                 455                 460                 


Trp Gly Arg Gly Gly Leu Phe Xaa Ala Leu Glu Lys Arg Ser Ala Glu 
465                 470                 475                 480 


Pro Arg Lys Ile Tyr Glu Leu Ala Gly Lys Met Lys Asp Leu Ser Leu 
                485                 490                 495     


Gly Gly Val Leu Leu Phe Pro Val Asp Asp Lys Glu Ser Arg Asn Lys 
            500                 505                 510         


Gly Gln Asp Leu Leu Ala Leu Ile Val Ala Gln His Arg Asp Arg Ser 
        515                 520                 525             


Asn Val Leu Ser Gly Ile Lys Met Ala Ala Leu Glu Glu Gly Leu Lys 
    530                 535                 540                 


Lys Ile Phe Leu Ala Ala Lys Lys Lys Lys Ala Ser Val His Leu Pro 
545                 550                 555                 560 


Arg Ile Gly His Ala Xaa Lys Gly Phe Asn Trp Tyr Gly Xaa Glu Arg 
                565                 570                 575     


Leu Ile Arg Lys His Leu Ala Ala Arg Gly Ile Pro Xaa Tyr Ile Tyr 
            580                 585                 590         


Tyr Phe Pro Arg Ser Lys Ser Ala Val Leu His Ser Gln Ser Ser Ser 
        595                 600                 605             


Ser Ser Ser Arg Gln Leu Val Pro 
    610                 615     


<210> 5965
<211> 219
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<400> 5965
Glu Asp Asp Asp Asp Asp Glu Ala Pro Lys Arg Gln Xaa Arg Arg Arg 
1               5                   10                  15      


Ala Ala Lys Asn Val Ser Tyr Lys Glu Asp Asp Asp Phe Glu Xaa Asp 
            20                  25                  30          


Ser Asp Asp Leu Ile Glu Met Xaa Gly Glu Gly Val Asp Glu Gln Gln 
        35                  40                  45              


Asp Asn Ser Glu Xaa Ile Glu Lys Val Leu Asp Ser Arg Leu Gly Lys 
    50                  55                  60                  


Lys Gly Ala Xaa Gly Ala Ser Xaa Xaa Val Tyr Ala Ile Glu Ala Asn 
65                  70                  75                  80  


Gly Asp Pro Ser Gly Asp Phe Asp Xaa Glu Lys Asp Glu Gly Glu Ile 
                85                  90                  95      


Gln Tyr Leu Ile Lys Trp Lys Gly Trp Ser Tyr Ile His Ser Xaa Trp 
            100                 105                 110         


Glu Ser Glu Glu Ser Leu Gln Gln Gln Lys Val Lys Gly Leu Lys Lys 
        115                 120                 125             


Leu Glu Asn Phe Lys Lys Lys Glu Asp Glu Ile Lys Gln Trp Leu Gly 
    130                 135                 140                 


Lys Val Ser Pro Glu Asp Val Glu Tyr Phe Asn Cys Gln Gln Glu Leu 
145                 150                 155                 160 


Ala Ser Glu Leu Asn Lys Gln Tyr Gln Ile Val Glu Arg Val Ile Ala 
                165                 170                 175     


Val Lys Xaa Ser Lys Ser Xaa Leu Gly Gln Xaa Asp Phe Pro Ala His 
            180                 185                 190         


Ser Arg Lys Pro Ala Pro Ser Asn Glu Pro Glu Tyr Leu Trp Arg Arg 
        195                 200                 205             


Tyr Xaa Asp Lys Glu Asp Trp Xaa His Met Cys 
    210                 215                 


<210> 5966
<211> 98
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 5966
Glu Ile Tyr Met Leu Pro Arg Ile Arg Ser Ser Xaa Lys Lys Ala Gln 
1               5                   10                  15      


Xaa Asn Asp Ser Asp Ser Asp Xaa Glu Ser Lys Arg Gln Ala Gln Arg 
            20                  25                  30          


Ser Ser Ala Ser Glu Ser Glu Xaa Glu Asp Ser Asp Asp Asp Lys Lys 
        35                  40                  45              


Pro Lys Arg Arg Gly Arg Pro Arg Ser Val Arg Lys Asp Leu Val Glu 
    50                  55                  60                  


Gly Phe Xaa Asp Ala Glu Ile Arg Arg Phe Ile Lys Ala Tyr Lys Lys 
65                  70                  75                  80  


Phe Gly Leu Pro Leu Glu Arg Gly Met Xaa Lys Met Ile Lys Xaa Gly 
                85                  90                  95      


His Pro 
        


<210> 5967
<211> 35
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<400> 5967
Gly Val Glu Asp Asp Ser Arg Leu Leu Leu Gly Ile Tyr Glu His Gly 
1               5                   10                  15      


Tyr Gly Asn Trp Glu Leu Ile Lys Xaa Asp Pro Glu Leu Lys Leu Xaa 
            20                  25                  30          


Asp Lys Leu 
        35  


<210> 5968
<211> 514
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<400> 5968
Met Ala His Lys Gln Arg Glu Asp Tyr Leu Asn Leu Ser Pro Cys Val 
1               5                   10                  15      


Phe Xaa Trp Tyr Arg Xaa Phe Ser Gln Leu Ala Phe Asp Gly Glu Lys 
            20                  25                  30          


Leu Ser His Ser Ala Ser Glu Glu Ala Ser Gly Ser Asp Ser Gly Ser 
        35                  40                  45              


Gln Ser Glu Ser Glu Gln Gly Ser Asp Pro Gly Ser Gly His Gly Ser 
    50                  55                  60                  


Glu Ser Asn Ser Ser Ser Glu Ser Ser Glu Ser Gln Ser Glu Ser Glu 
65                  70                  75                  80  


Ser Glu Ser Ala Gly Ser Lys Ser Gln Pro Val Leu Pro Glu Ala Lys 
                85                  90                  95      


Glu Lys Pro Ala Ser Lys Lys Glu Arg Ile Ala Asp Val Lys Lys Met 
            100                 105                 110         


Trp Glu Glu Tyr Pro Asp Val Tyr Gly Val Arg Arg Ser Asn Arg Ser 
        115                 120                 125             


Arg Gln Glu Pro Ser Arg Phe Asn Ile Lys Glu Glu Ala Ser Ser Gly 
    130                 135                 140                 


Ser Glu Ser Gly Ser Pro Lys Arg Arg Gly Gln Arg Gln Leu Lys Lys 
145                 150                 155                 160 


Gln Glu Lys Trp Lys Gln Glu Pro Ser Glu Asp Glu Gln Glu Gln Gly 
                165                 170                 175     


Xaa Ser Ala Glu Ser Glu Pro Glu Gln Lys Lys Val Lys Ala Arg Arg 
            180                 185                 190         


Pro Val Pro Arg Arg Xaa Val Pro Lys Pro Arg Val Lys Lys Gln Pro 
        195                 200                 205             


Lys Xaa Gln Arg Gly Lys Arg Lys Lys Gln Asp Ser Ser Asp Glu Asp 
    210                 215                 220                 


Asp Asp Asp Asp Glu Ala Pro Lys Arg Gln Xaa Arg Arg Arg Ala Ala 
225                 230                 235                 240 


Lys Asn Val Ser Tyr Lys Glu Asp Asp Asp Phe Glu Xaa Asp Ser Asp 
                245                 250                 255     


Asp Leu Ile Glu Met Xaa Gly Glu Gly Val Asp Glu Gln Gln Asp Asn 
            260                 265                 270         


Ser Glu Xaa Ile Glu Lys Val Leu Asp Ser Arg Leu Gly Lys Lys Gly 
        275                 280                 285             


Ala Xaa Gly Ala Ser Xaa Xaa Val Tyr Ala Ile Glu Ala Asn Gly Asp 
    290                 295                 300                 


Pro Ser Gly Asp Phe Asp Xaa Glu Lys Asp Glu Gly Glu Ile Gln Tyr 
305                 310                 315                 320 


Leu Ile Lys Trp Lys Gly Trp Ser Tyr Ile His Ser Xaa Trp Glu Ser 
                325                 330                 335     


Glu Glu Ser Leu Gln Gln Gln Lys Val Lys Gly Leu Lys Lys Leu Glu 
            340                 345                 350         


Asn Phe Lys Lys Lys Glu Asp Glu Ile Lys Gln Trp Leu Gly Lys Val 
        355                 360                 365             


Ser Pro Glu Asp Val Glu Tyr Phe Asn Cys Gln Gln Glu Leu Ala Ser 
    370                 375                 380                 


Glu Leu Asn Lys Gln Tyr Gln Ile Val Glu Arg Val Ile Ala Val Lys 
385                 390                 395                 400 


Xaa Ser Lys Ser Xaa Leu Gly Gln Xaa Asp Phe Pro Ala His Ser Arg 
                405                 410                 415     


Lys Pro Ala Pro Ser Asn Glu Pro Glu Tyr Leu Cys Lys Trp Met Gly 
            420                 425                 430         


Leu Pro Tyr Ser Glu Cys Ser Trp Glu Asp Glu Ala Leu Ile Gly Lys 
        435                 440                 445             


Lys Phe Gln Asn Cys Ile Asp Ser Phe His Ser Arg Asn Asn Ser Lys 
    450                 455                 460                 


Xaa Ile Pro Xaa Arg Glu Cys Lys Ala Leu Lys Gln Arg Pro Arg Phe 
465                 470                 475                 480 


Val Ala Leu Lys Lys Gln Pro Ala Tyr Leu Gly Gly Glu Asn Leu Glu 
                485                 490                 495     


Leu Arg Asp Tyr Gln Leu Glu Gly Leu Asn Trp Leu Ala His Ser Trp 
            500                 505                 510         


Cys Lys 
        


<210> 5969
<211> 31
<212> PRT
<213> Homo sapiens

<400> 5969
Met Met Arg Asn Lys Asp Lys Ser Gln Glu Glu Asp Ser Ser Leu His 
1               5                   10                  15      


Ser Asn Ala Ser Arg Val Val Trp Asn Ala Leu Ser Ser Glu Ala 
            20                  25                  30      


<210> 5970
<211> 45
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<400> 5970
Met Met Arg Asn Lys Asp Lys Ser Gln Glu Glu Asp Ser Ser Leu His 
1               5                   10                  15      


Ser Asn Ala Ser Arg Tyr Glu Leu Ser Xaa Phe Phe Leu Phe Val Phe 
            20                  25                  30          


Phe Phe Gly Gly Glu Xaa Ser Ala Tyr Asn Cys Leu Pro 
        35                  40                  45  


<210> 5971
<211> 1828
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1105)..(1105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1293)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1448)..(1448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1502)..(1502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1541)..(1541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1597)..(1597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1767)..(1767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1828)..(1828)
<223> Selenocysteine

<400> 5971
Met Met Arg Asn Lys Asp Lys Ser Gln Glu Glu Asp Ser Ser Leu His 
1               5                   10                  15      


Ser Asn Ala Ser Ser His Ser Ala Ser Glu Glu Ala Ser Gly Ser Asp 
            20                  25                  30          


Ser Gly Ser Gln Ser Glu Ser Glu Gln Gly Ser Asp Pro Gly Ser Gly 
        35                  40                  45              


His Gly Ser Glu Ser Asn Ser Ser Ser Glu Ser Ser Glu Ser Gln Ser 
    50                  55                  60                  


Glu Ser Glu Ser Glu Ser Ala Gly Ser Lys Ser Gln Pro Val Leu Pro 
65                  70                  75                  80  


Glu Ala Lys Glu Lys Pro Ala Ser Lys Lys Glu Arg Ile Ala Asp Val 
                85                  90                  95      


Lys Lys Met Trp Glu Glu Tyr Pro Asp Val Tyr Gly Val Arg Arg Ser 
            100                 105                 110         


Asn Arg Ser Arg Gln Glu Pro Ser Arg Phe Asn Ile Lys Glu Glu Ala 
        115                 120                 125             


Ser Ser Gly Ser Glu Ser Gly Ser Pro Lys Arg Arg Gly Gln Arg Gln 
    130                 135                 140                 


Leu Lys Lys Gln Glu Lys Trp Lys Gln Glu Pro Ser Glu Asp Glu Gln 
145                 150                 155                 160 


Glu Gln Gly Xaa Ser Ala Glu Ser Glu Pro Glu Gln Lys Lys Val Lys 
                165                 170                 175     


Ala Arg Arg Pro Val Pro Arg Arg Xaa Val Pro Lys Pro Arg Val Lys 
            180                 185                 190         


Lys Gln Pro Lys Xaa Gln Arg Gly Lys Arg Lys Lys Gln Asp Ser Ser 
        195                 200                 205             


Asp Glu Asp Asp Asp Asp Asp Glu Ala Pro Lys Arg Gln Xaa Arg Arg 
    210                 215                 220                 


Arg Ala Ala Lys Asn Val Ser Tyr Lys Glu Asp Asp Asp Phe Glu Xaa 
225                 230                 235                 240 


Asp Ser Asp Asp Leu Ile Glu Met Xaa Gly Glu Gly Val Asp Glu Gln 
                245                 250                 255     


Gln Asp Asn Ser Glu Xaa Ile Glu Lys Val Leu Asp Ser Arg Leu Gly 
            260                 265                 270         


Lys Lys Gly Ala Xaa Gly Ala Ser Xaa Xaa Val Tyr Ala Ile Glu Ala 
        275                 280                 285             


Asn Gly Asp Pro Ser Gly Asp Phe Asp Xaa Glu Lys Asp Glu Gly Glu 
    290                 295                 300                 


Ile Gln Tyr Leu Ile Lys Trp Lys Gly Trp Ser Tyr Ile His Ser Xaa 
305                 310                 315                 320 


Trp Glu Ser Glu Glu Ser Leu Gln Gln Gln Lys Val Lys Gly Leu Lys 
                325                 330                 335     


Lys Leu Glu Asn Phe Lys Lys Lys Glu Asp Glu Ile Lys Gln Trp Leu 
            340                 345                 350         


Gly Lys Val Ser Pro Glu Asp Val Glu Tyr Phe Asn Cys Gln Gln Glu 
        355                 360                 365             


Leu Ala Ser Glu Leu Asn Lys Gln Tyr Gln Ile Val Glu Arg Val Ile 
    370                 375                 380                 


Ala Val Lys Xaa Ser Lys Ser Xaa Leu Gly Gln Xaa Asp Phe Pro Ala 
385                 390                 395                 400 


His Ser Arg Lys Pro Ala Pro Ser Asn Glu Pro Glu Tyr Leu Cys Lys 
                405                 410                 415     


Trp Met Gly Leu Pro Tyr Ser Glu Cys Ser Trp Glu Asp Glu Ala Leu 
            420                 425                 430         


Ile Gly Lys Lys Phe Gln Asn Cys Ile Asp Ser Phe His Ser Arg Asn 
        435                 440                 445             


Asn Ser Lys Xaa Ile Pro Xaa Arg Glu Cys Lys Ala Leu Lys Gln Arg 
    450                 455                 460                 


Pro Arg Phe Val Ala Leu Lys Lys Gln Pro Ala Tyr Leu Gly Gly Glu 
465                 470                 475                 480 


Asn Leu Glu Leu Arg Asp Tyr Gln Leu Glu Gly Leu Asn Trp Leu Ala 
                485                 490                 495     


His Ser Trp Cys Lys Asn Asn Ser Val Ile Leu Ala Asp Glu Met Gly 
            500                 505                 510         


Leu Gly Lys Xaa Ile Gln Xaa Ile Ser Phe Leu Ser Tyr Leu Phe His 
        515                 520                 525             


Gln His Gln Leu Tyr Gly Pro Phe Leu Ile Val Val Pro Leu Ser Xaa 
    530                 535                 540                 


Leu Xaa Ser Trp Gln Arg Glu Phe Glu Ile Trp Ala Pro Glu Ile Asn 
545                 550                 555                 560 


Val Val Val Tyr Ile Gly Asp Leu Met Ser Arg Asn Xaa Ile Arg Glu 
                565                 570                 575     


Tyr Glu Trp Ile His Ser Gln Xaa Lys Arg Leu Lys Phe Asn Ala Leu 
            580                 585                 590         


Ile Xaa Xaa Tyr Glu Ile Leu Leu Lys Asp Lys Xaa Val Leu Gly Ser 
        595                 600                 605             


Ile Asn Trp Ala Phe Leu Gly Val Asp Glu Ala His Arg Leu Lys Asn 
    610                 615                 620                 


Asp Asp Ser Leu Leu Tyr Lys Xaa Leu Ile Asp Phe Lys Ser Asn His 
625                 630                 635                 640 


Arg Leu Leu Ile Xaa Gly Xaa Pro Leu Gln Asn Ser Leu Lys Glu Leu 
                645                 650                 655     


Trp Ser Leu Leu His Phe Ile Met Pro Glu Lys Phe Glu Phe Trp Glu 
            660                 665                 670         


Asp Phe Glu Glu Asp His Gly Lys Gly Arg Glu Asn Gly Tyr Gln Ser 
        675                 680                 685             


Leu His Lys Val Leu Glu Pro Phe Leu Leu Arg Arg Val Lys Lys Asp 
    690                 695                 700                 


Val Glu Lys Ser Leu Pro Ala Lys Val Glu Gln Ile Leu Arg Val Glu 
705                 710                 715                 720 


Met Ser Ala Leu Gln Lys Gln Tyr Tyr Lys Trp Ile Leu Xaa Arg Asn 
                725                 730                 735     


Tyr Lys Ala Leu Ala Lys Gly Xaa Arg Gly Ser Xaa Ser Gly Phe Leu 
            740                 745                 750         


Asn Ile Val Met Glu Leu Lys Lys Cys Cys Asn His Cys Tyr Leu Ile 
        755                 760                 765             


Lys Pro Pro Glu Glu Asn Glu Arg Glu Asn Gly Gln Glu Ile Leu Leu 
    770                 775                 780                 


Ser Leu Ile Arg Ser Ser Gly Lys Leu Ile Leu Leu Asp Lys Leu Leu 
785                 790                 795                 800 


Xaa Arg Leu Arg Glu Arg Gly Asn Arg Val Leu Ile Phe Ser Gln Met 
                805                 810                 815     


Val Arg Met Leu Asp Ile Leu Ala Glu Tyr Leu Xaa Ile Lys His Tyr 
            820                 825                 830         


Pro Phe Gln Arg Leu Asp Gly Ser Ile Lys Gly Glu Ile Arg Lys Gln 
        835                 840                 845             


Ala Leu Asp His Phe Asn Ala Asp Gly Ser Glu Asp Phe Cys Phe Leu 
    850                 855                 860                 


Leu Ser Xaa Arg Ala Gly Gly Leu Gly Ile Asn Leu Ala Ser Ala Asp 
865                 870                 875                 880 


Xaa Val Val Ile Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu Gln 
                885                 890                 895     


Ala Gln Ala Arg Ala His Arg Ile Gly Gln Lys Lys Gln Val Asn Ile 
            900                 905                 910         


Tyr Arg Leu Val Xaa Lys Gly Xaa Val Glu Glu Glu Ile Ile Glu Arg 
        915                 920                 925             


Ala Lys Lys Lys Met Val Leu Asp His Leu Val Ile Gln Arg Met Asp 
    930                 935                 940                 


Xaa Xaa Gly Arg Xaa Ile Leu Glu Asn Asn Ser Gly Arg Ser Asn Ser 
945                 950                 955                 960 


Asn Pro Phe Asn Lys Glu Glu Leu Xaa Ala Ile Leu Lys Phe Gly Ala 
                965                 970                 975     


Glu Asp Leu Phe Lys Glu Leu Glu Gly Glu Glu Ser Glu Pro Gln Glu 
            980                 985                 990         


Met Asp Ile Asp Glu Ile Leu Arg  Leu Ala Glu Xaa Arg  Glu Asn Glu 
        995                 1000                 1005             


Val Ser  Xaa Ser Ala Xaa Asp  Glu Leu Leu Ser Gln  Phe Lys Val 
    1010                 1015                 1020             


Ala Asn  Phe Ala Xaa Met Glu  Asp Glu Glu Glu Leu  Glu Glu Arg 
    1025                 1030                 1035             


Pro His  Lys Asp Trp Asp Glu  Ile Ile Pro Glu Glu  Gln Arg Lys 
    1040                 1045                 1050             


Lys Val  Glu Glu Glu Glu Arg  Gln Lys Glu Leu Glu  Glu Ile Tyr 
    1055                 1060                 1065             


Met Leu  Pro Arg Ile Arg Ser  Ser Xaa Lys Lys Ala  Gln Xaa Asn 
    1070                 1075                 1080             


Asp Ser  Asp Ser Asp Xaa Glu  Ser Lys Arg Gln Ala  Gln Arg Ser 
    1085                 1090                 1095             


Ser Ala  Ser Glu Ser Glu Xaa  Glu Asp Ser Asp Asp  Asp Lys Lys 
    1100                 1105                 1110             


Pro Lys  Arg Arg Gly Arg Pro  Arg Ser Val Arg Lys  Asp Leu Val 
    1115                 1120                 1125             


Glu Gly  Phe Xaa Asp Ala Glu  Ile Arg Arg Phe Ile  Lys Ala Tyr 
    1130                 1135                 1140             


Lys Lys  Phe Gly Leu Pro Leu  Glu Arg Leu Glu Cys  Ile Ala Arg 
    1145                 1150                 1155             


Asp Ala  Glu Leu Val Asp Lys  Ser Val Ala Asp Leu  Lys Arg Leu 
    1160                 1165                 1170             


Gly Glu  Leu Ile His Asn Ser  Cys Val Ser Ala Met  Gln Glu Tyr 
    1175                 1180                 1185             


Glu Glu  Gln Leu Lys Glu Asn  Ala Ser Glu Gly Lys  Gly Pro Gly 
    1190                 1195                 1200             


Lys Arg  Arg Gly Pro Xaa Ile  Lys Ile Ser Gly Val  Gln Val Asn 
    1205                 1210                 1215             


Val Lys  Ser Ile Ile Gln His  Glu Glu Glu Phe Glu  Met Leu His 
    1220                 1225                 1230             


Lys Ser  Ile Pro Val Asp Pro  Glu Glu Lys Lys Lys  Tyr Cys Leu 
    1235                 1240                 1245             


Xaa Cys  Arg Val Lys Ala Ala  His Phe Asp Val Glu  Trp Gly Val 
    1250                 1255                 1260             


Glu Asp  Asp Ser Arg Leu Leu  Leu Gly Ile Tyr Glu  His Gly Tyr 
    1265                 1270                 1275             


Gly Asn  Trp Glu Leu Ile Lys  Xaa Asp Pro Glu Leu  Lys Leu Xaa 
    1280                 1285                 1290             


Asp Lys  Ile Leu Pro Val Glu  Xaa Asp Lys Lys Pro  Gln Gly Lys 
    1295                 1300                 1305             


Gln Leu  Gln Xaa Arg Ala Asp  Tyr Leu Leu Lys Leu  Leu Arg Lys 
    1310                 1315                 1320             


Gly Leu  Glu Lys Lys Gly Ala  Val Xaa Gly Gly Glu  Glu Ala Lys 
    1325                 1330                 1335             


Leu Lys  Lys Arg Lys Pro Arg  Val Lys Lys Glu Asn  Lys Val Pro 
    1340                 1345                 1350             


Arg Leu  Lys Glu Glu His Gly  Ile Glu Leu Ser Ser  Pro Arg His 
    1355                 1360                 1365             


Ser Asp  Asn Pro Ser Glu Glu  Gly Glu Val Lys Asp  Asp Gly Leu 
    1370                 1375                 1380             


Glu Lys  Ser Pro Met Lys Lys  Lys Gln Lys Lys Lys  Glu Asn Lys 
    1385                 1390                 1395             


Glu Asn  Lys Glu Lys Gln Met  Ser Ser Arg Lys Asp  Lys Glu Gly 
    1400                 1405                 1410             


Asp Lys  Glu Arg Lys Lys Ser  Lys Asp Lys Lys Glu  Lys Pro Lys 
    1415                 1420                 1425             


Ser Gly  Asp Ala Lys Ser Ser  Ser Lys Ser Lys Arg  Ser Gln Gly 
    1430                 1435                 1440             


Pro Val  His Ile Xaa Ala Gly  Ser Glu Pro Val Pro  Ile Gly Glu 
    1445                 1450                 1455             


Asp Glu  Asp Asp Asp Leu Asp  Gln Glu Xaa Phe Ser  Ile Cys Lys 
    1460                 1465                 1470             


Glu Arg  Met Arg Pro Val Lys  Lys Ala Leu Lys Gln  Leu Asp Lys 
    1475                 1480                 1485             


Pro Asp  Lys Gly Leu Asn Val  Gln Glu Gln Leu Glu  His Xaa Arg 
    1490                 1495                 1500             


Asn Cys  Leu Leu Lys Ile Gly  Asp Arg Ile Ala Glu  Cys Leu Lys 
    1505                 1510                 1515             


Ala Tyr  Ser Asp Gln Glu His  Ile Lys Leu Trp Arg  Arg Asn Leu 
    1520                 1525                 1530             


Trp Ile  Phe Val Ser Lys Phe  Xaa Glu Phe Asp Ala  Arg Lys Leu 
    1535                 1540                 1545             


His Lys  Leu Tyr Lys Met Ala  His Lys Lys Arg Ser  Gln Glu Glu 
    1550                 1555                 1560             


Glu Glu  Gln Lys Lys Lys Asp  Asp Val Xaa Gly Gly  Lys Lys Pro 
    1565                 1570                 1575             


Phe Arg  Pro Glu Ala Ser Gly  Ser Ser Arg Asp Ser  Leu Ile Ser 
    1580                 1585                 1590             


Gln Ser  His Xaa Ser His Asn  Leu His Pro Gln Lys  Pro His Leu 
    1595                 1600                 1605             


Pro Ala  Ser His Gly Pro Gln  Met His Gly His Pro  Arg Asp Asn 
    1610                 1615                 1620             


Tyr Asn  His Pro Asn Lys Arg  His Phe Ser Asn Ala  Asp Arg Gly 
    1625                 1630                 1635             


Asp Trp  Gln Arg Glu Arg Lys  Phe Asn Tyr Gly Gly  Gly Asn Asn 
    1640                 1645                 1650             


Asn Pro  Pro Trp Gly Ser Asp  Arg His His Gln Tyr  Glu Gln His 
    1655                 1660                 1665             


Trp Tyr  Lys Asp His His Tyr  Gly Asp Arg Arg His  Met Asp Ala 
    1670                 1675                 1680             


His Arg  Ser Gly Ser Tyr Arg  Pro Asn Asn Met Ser  Arg Lys Arg 
    1685                 1690                 1695             


Pro Tyr  Asp Gln Tyr Ser Ser  Asp Arg Asp His Arg  Gly His Arg 
    1700                 1705                 1710             


Asp Tyr  Tyr Asp Arg His His  His Asp Ser Lys Arg  Arg Arg Ser 
    1715                 1720                 1725             


Asp Glu  Phe Arg Pro Gln Asn  Tyr His Gln Gln Asp  Phe Arg Arg 
    1730                 1735                 1740             


Met Ser  Asp His Arg Pro Ala  Met Gly Tyr His Gly  Gln Gly Pro 
    1745                 1750                 1755             


Ser Asp  His Tyr Arg Ser Phe  His Xaa Asp Lys Leu  Gly Glu Tyr 
    1760                 1765                 1770             


Lys Gln  Pro Leu Pro Pro Leu  His Pro Ala Val Ser  Asp Pro Arg 
    1775                 1780                 1785             


Ser Pro  Pro Ser Gln Lys Ser  Pro His Asp Ser Lys  Ser Pro Leu 
    1790                 1795                 1800             


Asp His  Arg Ser Pro Leu Glu  Arg Ser Leu Glu Gln  Lys Asn Asn 
    1805                 1810                 1815             


Pro Asp  Tyr Asn Trp Asn Val  Arg Lys Xaa 
    1820                 1825             


<210> 5972
<211> 1739
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1105)..(1105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1293)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1312)..(1312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1332)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1448)..(1448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1502)..(1502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1541)..(1541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1597)..(1597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1725)..(1725)
<223> Selenocysteine

<400> 5972
Met Met Arg Asn Lys Asp Lys Ser Gln Glu Glu Asp Ser Ser Leu His 
1               5                   10                  15      


Ser Asn Ala Ser Ser His Ser Ala Ser Glu Glu Ala Ser Gly Ser Asp 
            20                  25                  30          


Ser Gly Ser Gln Ser Glu Ser Glu Gln Gly Ser Asp Pro Gly Ser Gly 
        35                  40                  45              


His Gly Ser Glu Ser Asn Ser Ser Ser Glu Ser Ser Glu Ser Gln Ser 
    50                  55                  60                  


Glu Ser Glu Ser Glu Ser Ala Gly Ser Lys Ser Gln Pro Val Leu Pro 
65                  70                  75                  80  


Glu Ala Lys Glu Lys Pro Ala Ser Lys Lys Glu Arg Ile Ala Asp Val 
                85                  90                  95      


Lys Lys Met Trp Glu Glu Tyr Pro Asp Val Tyr Gly Val Arg Arg Ser 
            100                 105                 110         


Asn Arg Ser Arg Gln Glu Pro Ser Arg Phe Asn Ile Lys Glu Glu Ala 
        115                 120                 125             


Ser Ser Gly Ser Glu Ser Gly Ser Pro Lys Arg Arg Gly Gln Arg Gln 
    130                 135                 140                 


Leu Lys Lys Gln Glu Lys Trp Lys Gln Glu Pro Ser Glu Asp Glu Gln 
145                 150                 155                 160 


Glu Gln Gly Xaa Ser Ala Glu Ser Glu Pro Glu Gln Lys Lys Val Lys 
                165                 170                 175     


Ala Arg Arg Pro Val Pro Arg Arg Xaa Val Pro Lys Pro Arg Val Lys 
            180                 185                 190         


Lys Gln Pro Lys Xaa Gln Arg Gly Lys Arg Lys Lys Gln Asp Ser Ser 
        195                 200                 205             


Asp Glu Asp Asp Asp Asp Asp Glu Ala Pro Lys Arg Gln Xaa Arg Arg 
    210                 215                 220                 


Arg Ala Ala Lys Asn Val Ser Tyr Lys Glu Asp Asp Asp Phe Glu Xaa 
225                 230                 235                 240 


Asp Ser Asp Asp Leu Ile Glu Met Xaa Gly Glu Gly Val Asp Glu Gln 
                245                 250                 255     


Gln Asp Asn Ser Glu Xaa Ile Glu Lys Val Leu Asp Ser Arg Leu Gly 
            260                 265                 270         


Lys Lys Gly Ala Xaa Gly Ala Ser Xaa Xaa Val Tyr Ala Ile Glu Ala 
        275                 280                 285             


Asn Gly Asp Pro Ser Gly Asp Phe Asp Xaa Glu Lys Asp Glu Gly Glu 
    290                 295                 300                 


Ile Gln Tyr Leu Ile Lys Trp Lys Gly Trp Ser Tyr Ile His Ser Xaa 
305                 310                 315                 320 


Trp Glu Ser Glu Glu Ser Leu Gln Gln Gln Lys Val Lys Gly Leu Lys 
                325                 330                 335     


Lys Leu Glu Asn Phe Lys Lys Lys Glu Asp Glu Ile Lys Gln Trp Leu 
            340                 345                 350         


Gly Lys Val Ser Pro Glu Asp Val Glu Tyr Phe Asn Cys Gln Gln Glu 
        355                 360                 365             


Leu Ala Ser Glu Leu Asn Lys Gln Tyr Gln Ile Val Glu Arg Val Ile 
    370                 375                 380                 


Ala Val Lys Xaa Ser Lys Ser Xaa Leu Gly Gln Xaa Asp Phe Pro Ala 
385                 390                 395                 400 


His Ser Arg Lys Pro Ala Pro Ser Asn Glu Pro Glu Tyr Leu Cys Lys 
                405                 410                 415     


Trp Met Gly Leu Pro Tyr Ser Glu Cys Ser Trp Glu Asp Glu Ala Leu 
            420                 425                 430         


Ile Gly Lys Lys Phe Gln Asn Cys Ile Asp Ser Phe His Ser Arg Asn 
        435                 440                 445             


Asn Ser Lys Xaa Ile Pro Xaa Arg Glu Cys Lys Ala Leu Lys Gln Arg 
    450                 455                 460                 


Pro Arg Phe Val Ala Leu Lys Lys Gln Pro Ala Tyr Leu Gly Gly Glu 
465                 470                 475                 480 


Asn Leu Glu Leu Arg Asp Tyr Gln Leu Glu Gly Leu Asn Trp Leu Ala 
                485                 490                 495     


His Ser Trp Cys Lys Asn Asn Ser Val Ile Leu Ala Asp Glu Met Gly 
            500                 505                 510         


Leu Gly Lys Xaa Ile Gln Xaa Ile Ser Phe Leu Ser Tyr Leu Phe His 
        515                 520                 525             


Gln His Gln Leu Tyr Gly Pro Phe Leu Ile Val Val Pro Leu Ser Xaa 
    530                 535                 540                 


Leu Xaa Ser Trp Gln Arg Glu Phe Glu Ile Trp Ala Pro Glu Ile Asn 
545                 550                 555                 560 


Val Val Val Tyr Ile Gly Asp Leu Met Ser Arg Asn Xaa Ile Arg Glu 
                565                 570                 575     


Tyr Glu Trp Ile His Ser Gln Xaa Lys Arg Leu Lys Phe Asn Ala Leu 
            580                 585                 590         


Ile Xaa Xaa Tyr Glu Ile Leu Leu Lys Asp Lys Xaa Val Leu Gly Ser 
        595                 600                 605             


Ile Asn Trp Ala Phe Leu Gly Val Asp Glu Ala His Arg Leu Lys Asn 
    610                 615                 620                 


Asp Asp Ser Leu Leu Tyr Lys Xaa Leu Ile Asp Phe Lys Ser Asn His 
625                 630                 635                 640 


Arg Leu Leu Ile Xaa Gly Xaa Pro Leu Gln Asn Ser Leu Lys Glu Leu 
                645                 650                 655     


Trp Ser Leu Leu His Phe Ile Met Pro Glu Lys Phe Glu Phe Trp Glu 
            660                 665                 670         


Asp Phe Glu Glu Asp His Gly Lys Gly Arg Glu Asn Gly Tyr Gln Ser 
        675                 680                 685             


Leu His Lys Val Leu Glu Pro Phe Leu Leu Arg Arg Val Lys Lys Asp 
    690                 695                 700                 


Val Glu Lys Ser Leu Pro Ala Lys Val Glu Gln Ile Leu Arg Val Glu 
705                 710                 715                 720 


Met Ser Ala Leu Gln Lys Gln Tyr Tyr Lys Trp Ile Leu Xaa Arg Asn 
                725                 730                 735     


Tyr Lys Ala Leu Ala Lys Gly Xaa Arg Gly Ser Xaa Ser Gly Phe Leu 
            740                 745                 750         


Asn Ile Val Met Glu Leu Lys Lys Cys Cys Asn His Cys Tyr Leu Ile 
        755                 760                 765             


Lys Pro Pro Glu Glu Asn Glu Arg Glu Asn Gly Gln Glu Ile Leu Leu 
    770                 775                 780                 


Ser Leu Ile Arg Ser Ser Gly Lys Leu Ile Leu Leu Asp Lys Leu Leu 
785                 790                 795                 800 


Xaa Arg Leu Arg Glu Arg Gly Asn Arg Val Leu Ile Phe Ser Gln Met 
                805                 810                 815     


Val Arg Met Leu Asp Ile Leu Ala Glu Tyr Leu Xaa Ile Lys His Tyr 
            820                 825                 830         


Pro Phe Gln Arg Leu Asp Gly Ser Ile Lys Gly Glu Ile Arg Lys Gln 
        835                 840                 845             


Ala Leu Asp His Phe Asn Ala Asp Gly Ser Glu Asp Phe Cys Phe Leu 
    850                 855                 860                 


Leu Ser Xaa Arg Ala Gly Gly Leu Gly Ile Asn Leu Ala Ser Ala Asp 
865                 870                 875                 880 


Xaa Val Val Ile Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu Gln 
                885                 890                 895     


Ala Gln Ala Arg Ala His Arg Ile Gly Gln Lys Lys Gln Val Asn Ile 
            900                 905                 910         


Tyr Arg Leu Val Xaa Lys Gly Xaa Val Glu Glu Glu Ile Ile Glu Arg 
        915                 920                 925             


Ala Lys Lys Lys Met Val Leu Asp His Leu Val Ile Gln Arg Met Asp 
    930                 935                 940                 


Xaa Xaa Gly Arg Xaa Ile Leu Glu Asn Asn Ser Gly Arg Ser Asn Ser 
945                 950                 955                 960 


Asn Pro Phe Asn Lys Glu Glu Leu Xaa Ala Ile Leu Lys Phe Gly Ala 
                965                 970                 975     


Glu Asp Leu Phe Lys Glu Leu Glu Gly Glu Glu Ser Glu Pro Gln Glu 
            980                 985                 990         


Met Asp Ile Asp Glu Ile Leu Arg  Leu Ala Glu Xaa Arg  Glu Asn Glu 
        995                 1000                 1005             


Val Ser  Xaa Ser Ala Xaa Asp  Glu Leu Leu Ser Gln  Phe Lys Val 
    1010                 1015                 1020             


Ala Asn  Phe Ala Xaa Met Glu  Asp Glu Glu Glu Leu  Glu Glu Arg 
    1025                 1030                 1035             


Pro His  Lys Asp Trp Asp Glu  Ile Ile Pro Glu Glu  Gln Arg Lys 
    1040                 1045                 1050             


Lys Val  Glu Glu Glu Glu Arg  Gln Lys Glu Leu Glu  Glu Ile Tyr 
    1055                 1060                 1065             


Met Leu  Pro Arg Ile Arg Ser  Ser Xaa Lys Lys Ala  Gln Xaa Asn 
    1070                 1075                 1080             


Asp Ser  Asp Ser Asp Xaa Glu  Ser Lys Arg Gln Ala  Gln Arg Ser 
    1085                 1090                 1095             


Ser Ala  Ser Glu Ser Glu Xaa  Glu Asp Ser Asp Asp  Asp Lys Lys 
    1100                 1105                 1110             


Pro Lys  Arg Arg Gly Arg Pro  Arg Ser Val Arg Lys  Asp Leu Val 
    1115                 1120                 1125             


Glu Gly  Phe Xaa Asp Ala Glu  Ile Arg Arg Phe Ile  Lys Ala Tyr 
    1130                 1135                 1140             


Lys Lys  Phe Gly Leu Pro Leu  Glu Arg Leu Glu Cys  Ile Ala Arg 
    1145                 1150                 1155             


Asp Ala  Glu Leu Val Asp Lys  Ser Val Ala Asp Leu  Lys Arg Leu 
    1160                 1165                 1170             


Gly Glu  Leu Ile His Asn Ser  Cys Val Ser Ala Met  Gln Glu Tyr 
    1175                 1180                 1185             


Glu Glu  Gln Leu Lys Glu Asn  Ala Ser Glu Gly Lys  Gly Pro Gly 
    1190                 1195                 1200             


Lys Arg  Arg Gly Pro Xaa Ile  Lys Ile Ser Gly Val  Gln Val Asn 
    1205                 1210                 1215             


Val Lys  Ser Ile Ile Gln His  Glu Glu Glu Phe Glu  Met Leu His 
    1220                 1225                 1230             


Lys Ser  Ile Pro Val Asp Pro  Glu Glu Lys Lys Lys  Tyr Cys Leu 
    1235                 1240                 1245             


Xaa Cys  Arg Val Lys Ala Ala  His Phe Asp Val Glu  Trp Gly Val 
    1250                 1255                 1260             


Glu Asp  Asp Ser Arg Leu Leu  Leu Gly Ile Tyr Glu  His Gly Tyr 
    1265                 1270                 1275             


Gly Asn  Trp Glu Leu Ile Lys  Xaa Asp Pro Glu Leu  Lys Leu Xaa 
    1280                 1285                 1290             


Asp Lys  Ile Leu Pro Val Glu  Xaa Asp Lys Lys Pro  Gln Gly Lys 
    1295                 1300                 1305             


Gln Leu  Gln Xaa Arg Ala Asp  Tyr Leu Leu Lys Leu  Leu Arg Lys 
    1310                 1315                 1320             


Gly Leu  Glu Lys Lys Gly Ala  Val Xaa Gly Gly Glu  Glu Ala Lys 
    1325                 1330                 1335             


Leu Lys  Lys Arg Lys Pro Arg  Val Lys Lys Glu Asn  Lys Val Pro 
    1340                 1345                 1350             


Arg Leu  Lys Glu Glu His Gly  Ile Glu Leu Ser Ser  Pro Arg His 
    1355                 1360                 1365             


Ser Asp  Asn Pro Ser Glu Glu  Gly Glu Val Lys Asp  Asp Gly Leu 
    1370                 1375                 1380             


Glu Lys  Ser Pro Met Lys Lys  Lys Gln Lys Lys Lys  Glu Asn Lys 
    1385                 1390                 1395             


Glu Asn  Lys Glu Lys Gln Met  Ser Ser Arg Lys Asp  Lys Glu Gly 
    1400                 1405                 1410             


Asp Lys  Glu Arg Lys Lys Ser  Lys Asp Lys Lys Glu  Lys Pro Lys 
    1415                 1420                 1425             


Ser Gly  Asp Ala Lys Ser Ser  Ser Lys Ser Lys Arg  Ser Gln Gly 
    1430                 1435                 1440             


Pro Val  His Ile Xaa Ala Gly  Ser Glu Pro Val Pro  Ile Gly Glu 
    1445                 1450                 1455             


Asp Glu  Asp Asp Asp Leu Asp  Gln Glu Xaa Phe Ser  Ile Cys Lys 
    1460                 1465                 1470             


Glu Arg  Met Arg Pro Val Lys  Lys Ala Leu Lys Gln  Leu Asp Lys 
    1475                 1480                 1485             


Pro Asp  Lys Gly Leu Asn Val  Gln Glu Gln Leu Glu  His Xaa Arg 
    1490                 1495                 1500             


Asn Cys  Leu Leu Lys Ile Gly  Asp Arg Ile Ala Glu  Cys Leu Lys 
    1505                 1510                 1515             


Ala Tyr  Ser Asp Gln Glu His  Ile Lys Leu Trp Arg  Arg Asn Leu 
    1520                 1525                 1530             


Trp Ile  Phe Val Ser Lys Phe  Xaa Glu Phe Asp Ala  Arg Lys Leu 
    1535                 1540                 1545             


His Lys  Leu Tyr Lys Met Ala  His Lys Lys Arg Ser  Gln Glu Glu 
    1550                 1555                 1560             


Glu Glu  Gln Lys Lys Lys Asp  Asp Val Xaa Gly Gly  Lys Lys Pro 
    1565                 1570                 1575             


Phe Arg  Pro Glu Ala Ser Gly  Ser Ser Arg Asp Ser  Leu Ile Ser 
    1580                 1585                 1590             


Gln Ser  His Xaa Ser His Asn  Leu His Pro Gln Lys  Pro His Leu 
    1595                 1600                 1605             


Pro Ala  Ser His Gly Pro Gln  Met His Gly His Pro  Arg Asp Asn 
    1610                 1615                 1620             


Tyr Asn  His Pro Asn Lys Arg  His Phe Ser Asn Ala  Asp Arg Gly 
    1625                 1630                 1635             


Asp Trp  Gln Arg Glu Arg Lys  Phe Asn Tyr Gly Gly  Gly Asn Asn 
    1640                 1645                 1650             


Asn Pro  Pro Trp Gly Ser Asp  Arg His His Gln Tyr  Glu Gln His 
    1655                 1660                 1665             


Trp Tyr  Lys Asp His His Tyr  Gly Asp Arg Arg His  Met Asp Ala 
    1670                 1675                 1680             


His Arg  Ser Gly Ser Tyr Arg  Pro Asn Asn Met Ser  Arg Lys Arg 
    1685                 1690                 1695             


Pro Tyr  Asp Gln Tyr Ser Ser  Asp Arg Asp His Arg  Gly His Arg 
    1700                 1705                 1710             


Asp Tyr  Tyr Asp Arg Tyr Ala  Lys Gly Cys Glu Xaa  Pro Gly Ala 
    1715                 1720                 1725             


Asn Leu  Cys Gln Glu Leu Phe  Leu Gly Arg Lys 
    1730                 1735                 


<210> 5973
<211> 501
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<400> 5973
Met Met Arg Asn Lys Asp Lys Ser Gln Glu Glu Asp Ser Ser Leu His 
1               5                   10                  15      


Ser Asn Ala Ser Ser His Ser Ala Ser Glu Glu Ala Ser Gly Ser Asp 
            20                  25                  30          


Ser Gly Ser Gln Ser Glu Ser Glu Gln Gly Ser Asp Pro Gly Ser Gly 
        35                  40                  45              


His Gly Ser Glu Ser Asn Ser Ser Ser Glu Ser Ser Glu Ser Gln Ser 
    50                  55                  60                  


Glu Ser Glu Ser Glu Ser Ala Gly Ser Lys Ser Gln Pro Val Leu Pro 
65                  70                  75                  80  


Glu Ala Lys Glu Lys Pro Ala Ser Lys Lys Glu Arg Ile Ala Asp Val 
                85                  90                  95      


Lys Lys Met Trp Glu Glu Tyr Pro Asp Val Tyr Gly Val Arg Arg Ser 
            100                 105                 110         


Asn Arg Ser Arg Gln Glu Pro Ser Arg Phe Asn Ile Lys Glu Glu Ala 
        115                 120                 125             


Ser Ser Gly Ser Glu Ser Gly Ser Pro Lys Arg Arg Gly Gln Arg Gln 
    130                 135                 140                 


Leu Lys Lys Gln Glu Lys Trp Lys Gln Glu Pro Ser Glu Asp Glu Gln 
145                 150                 155                 160 


Glu Gln Gly Xaa Ser Ala Glu Ser Glu Pro Glu Gln Lys Lys Val Lys 
                165                 170                 175     


Ala Arg Arg Pro Val Pro Arg Arg Xaa Val Pro Lys Pro Arg Val Lys 
            180                 185                 190         


Lys Gln Pro Lys Xaa Gln Arg Gly Lys Arg Lys Lys Gln Asp Ser Ser 
        195                 200                 205             


Asp Glu Asp Asp Asp Asp Asp Glu Ala Pro Lys Arg Gln Xaa Arg Arg 
    210                 215                 220                 


Arg Ala Ala Lys Asn Val Ser Tyr Lys Glu Asp Asp Asp Phe Glu Xaa 
225                 230                 235                 240 


Asp Ser Asp Asp Leu Ile Glu Met Xaa Gly Glu Gly Val Asp Glu Gln 
                245                 250                 255     


Gln Asp Asn Ser Glu Xaa Ile Glu Lys Val Leu Asp Ser Arg Leu Gly 
            260                 265                 270         


Lys Lys Gly Ala Xaa Gly Ala Ser Xaa Xaa Val Tyr Ala Ile Glu Ala 
        275                 280                 285             


Asn Gly Asp Pro Ser Gly Asp Phe Asp Xaa Glu Lys Asp Glu Gly Glu 
    290                 295                 300                 


Ile Gln Tyr Leu Ile Lys Trp Lys Gly Trp Ser Tyr Ile His Ser Xaa 
305                 310                 315                 320 


Trp Glu Ser Glu Glu Ser Leu Gln Gln Gln Lys Val Lys Gly Leu Lys 
                325                 330                 335     


Lys Leu Glu Asn Phe Lys Lys Lys Glu Asp Glu Ile Lys Gln Trp Leu 
            340                 345                 350         


Gly Lys Val Ser Pro Glu Asp Val Glu Tyr Phe Asn Cys Gln Gln Glu 
        355                 360                 365             


Leu Ala Ser Glu Leu Asn Lys Gln Tyr Gln Ile Val Glu Arg Val Ile 
    370                 375                 380                 


Ala Val Lys Xaa Ser Lys Ser Xaa Leu Gly Gln Xaa Asp Phe Pro Ala 
385                 390                 395                 400 


His Ser Arg Lys Pro Ala Pro Ser Asn Glu Pro Glu Tyr Leu Cys Lys 
                405                 410                 415     


Trp Met Gly Leu Pro Tyr Ser Glu Cys Ser Trp Glu Asp Glu Ala Leu 
            420                 425                 430         


Ile Gly Lys Lys Phe Gln Asn Cys Ile Asp Ser Phe His Ser Arg Asn 
        435                 440                 445             


Asn Ser Lys Xaa Ile Pro Xaa Arg Glu Cys Lys Ala Leu Lys Gln Arg 
    450                 455                 460                 


Pro Arg Phe Val Ala Leu Lys Lys Gln Pro Ala Tyr Leu Gly Gly Glu 
465                 470                 475                 480 


Asn Leu Glu Leu Arg Asp Tyr Gln Leu Glu Gly Leu Asn Trp Leu Ala 
                485                 490                 495     


His Ser Trp Cys Lys 
            500     


<210> 5974
<211> 425
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<400> 5974
Met Met Arg Asn Lys Asp Lys Ser Gln Glu Glu Asp Ser Ser Leu His 
1               5                   10                  15      


Ser Asn Ala Ser Ser His Ser Ala Ser Glu Glu Ala Ser Gly Ser Asp 
            20                  25                  30          


Ser Gly Ser Gln Ser Glu Ser Glu Gln Gly Ser Asp Pro Gly Ser Gly 
        35                  40                  45              


His Gly Ser Glu Ser Asn Ser Ser Ser Glu Ser Ser Glu Ser Gln Ser 
    50                  55                  60                  


Glu Ser Glu Ser Glu Ser Ala Gly Ser Lys Ser Gln Pro Val Leu Pro 
65                  70                  75                  80  


Glu Ala Lys Glu Lys Pro Ala Ser Lys Lys Glu Arg Ile Ala Asp Val 
                85                  90                  95      


Lys Lys Met Trp Glu Glu Tyr Pro Asp Val Tyr Gly Val Arg Arg Ser 
            100                 105                 110         


Asn Arg Ser Arg Gln Glu Pro Ser Arg Phe Asn Ile Lys Glu Glu Ala 
        115                 120                 125             


Ser Ser Gly Ser Glu Ser Gly Ser Pro Lys Arg Arg Gly Gln Arg Gln 
    130                 135                 140                 


Leu Lys Lys Gln Xaa Val Pro Lys Pro Arg Val Lys Lys Gln Pro Lys 
145                 150                 155                 160 


Xaa Gln Arg Gly Lys Arg Lys Lys Gln Asp Ser Ser Asp Glu Asp Asp 
                165                 170                 175     


Asp Asp Asp Glu Ala Pro Lys Arg Gln Xaa Arg Arg Arg Ala Ala Lys 
            180                 185                 190         


Asn Val Ser Tyr Lys Glu Asp Asp Asp Phe Glu Xaa Asp Ser Asp Asp 
        195                 200                 205             


Leu Ile Glu Met Xaa Gly Glu Gly Val Asp Glu Gln Gln Asp Asn Ser 
    210                 215                 220                 


Glu Xaa Ile Glu Lys Val Leu Asp Ser Arg Leu Gly Lys Lys Gly Ala 
225                 230                 235                 240 


Xaa Gly Ala Ser Xaa Xaa Val Tyr Ala Ile Glu Ala Asn Gly Asp Pro 
                245                 250                 255     


Ser Gly Asp Phe Asp Xaa Glu Lys Asp Glu Gly Glu Ile Gln Tyr Leu 
            260                 265                 270         


Ile Lys Trp Lys Gly Trp Ser Tyr Ile His Ser Xaa Trp Glu Ser Glu 
        275                 280                 285             


Glu Ser Leu Gln Gln Gln Lys Val Lys Gly Leu Lys Lys Leu Glu Asn 
    290                 295                 300                 


Phe Lys Lys Lys Glu Asp Glu Ile Lys Gln Trp Leu Gly Lys Val Ser 
305                 310                 315                 320 


Pro Glu Asp Val Glu Tyr Phe Asn Cys Gln Gln Glu Leu Ala Ser Glu 
                325                 330                 335     


Leu Asn Lys Gln Tyr Gln Ile Val Glu Arg Val Ile Ala Val Lys Xaa 
            340                 345                 350         


Ser Lys Ser Xaa Leu Gly Gln Xaa Asp Phe Pro Ala His Ser Arg Lys 
        355                 360                 365             


Pro Ala Pro Ser Asn Glu Pro Glu Tyr Leu Cys Lys Trp Met Gly Leu 
    370                 375                 380                 


Pro Tyr Ser Glu Cys Ser Trp Glu Asp Glu Ala Leu Ile Gly Lys Lys 
385                 390                 395                 400 


Phe Gln Asn Cys Ile Asp Ser Phe His Ser Arg Asn Asn Ser Lys Xaa 
                405                 410                 415     


Ile Pro Xaa Arg Glu Cys Lys Val Trp 
            420                 425 


<210> 5975
<211> 57
<212> PRT
<213> Homo sapiens

<400> 5975
Met Trp Glu Glu Tyr Pro Asp Val Tyr Gly Val Arg Arg Ser Asn Arg 
1               5                   10                  15      


Ser Arg Gln Glu Pro Ser Arg Phe Asn Ile Lys Glu Glu Ala Ser Ser 
            20                  25                  30          


Gly Ser Glu Ser Gly Ser Pro Lys Arg Arg Gly Gln Arg Gln Leu Lys 
        35                  40                  45              


Lys Gln Glu Lys Trp Lys Gln Glu Pro 
    50                  55          


<210> 5976
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<400> 5976
Pro Pro Glu Glu Asn Glu Arg Glu Asn Gly Gln Glu Ile Leu Leu Arg 
1               5                   10                  15      


Leu Asp Gly Ser Ile Lys Gly Glu Ile Arg Lys Gln Ala Leu Asp His 
            20                  25                  30          


Phe Asn Ala Asp Gly Ser Glu Asp Phe Cys Phe Leu Leu Ser Xaa Arg 
        35                  40                  45              


Ala Gly Gly Leu Gly Ile Asn Leu Ala Ser Ala Asp Xaa Val Val Ile 
    50                  55                  60                  


Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu Gln Ala Gln Ala Arg 
65                  70                  75                  80  


Ala His Arg Ile Gly Gln Lys Lys Gln Val Asn Ile Tyr Arg Leu Val 
                85                  90                  95      


Xaa Lys Gly Xaa Val Glu Glu Glu Ile Ile Glu Arg Ala Lys Lys Lys 
            100                 105                 110         


Met 
    


<210> 5977
<211> 954
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (873)..(873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<400> 5977
Xaa Asp Asp Asp Asp Asp Glu Ala Pro Lys Arg Gln Xaa Arg Arg Arg 
1               5                   10                  15      


Ala Ala Lys Asn Val Ser Tyr Lys Glu Asp Asp Asp Phe Glu Xaa Asp 
            20                  25                  30          


Ser Asp Asp Leu Ile Glu Met Xaa Gly Glu Gly Val Asp Glu Gln Gln 
        35                  40                  45              


Asp Asn Ser Glu Xaa Ile Glu Lys Val Leu Asp Ser Arg Leu Gly Lys 
    50                  55                  60                  


Lys Gly Ala Xaa Gly Ala Ser Xaa Xaa Val Tyr Ala Ile Glu Ala Asn 
65                  70                  75                  80  


Gly Asp Pro Ser Gly Asp Phe Asp Xaa Glu Lys Asp Glu Gly Glu Ile 
                85                  90                  95      


Gln Tyr Leu Ile Lys Trp Lys Gly Trp Ser Tyr Ile His Ser Xaa Trp 
            100                 105                 110         


Glu Ser Glu Glu Ser Leu Gln Gln Gln Lys Val Lys Gly Leu Lys Lys 
        115                 120                 125             


Leu Glu Asn Phe Lys Lys Lys Glu Asp Glu Ile Lys Gln Trp Leu Gly 
    130                 135                 140                 


Lys Val Ser Pro Glu Asp Val Glu Tyr Phe Asn Cys Gln Gln Glu Leu 
145                 150                 155                 160 


Ala Ser Glu Leu Asn Lys Gln Tyr Gln Ile Val Glu Arg Val Ile Ala 
                165                 170                 175     


Val Lys Xaa Ser Lys Ser Xaa Leu Gly Gln Xaa Asp Phe Pro Ala His 
            180                 185                 190         


Ser Arg Lys Pro Ala Pro Ser Asn Glu Pro Glu Tyr Leu Cys Lys Trp 
        195                 200                 205             


Met Gly Leu Pro Tyr Ser Glu Cys Ser Trp Glu Asp Glu Ala Leu Ile 
    210                 215                 220                 


Gly Lys Lys Phe Gln Asn Cys Ile Asp Ser Phe His Ser Arg Asn Asn 
225                 230                 235                 240 


Ser Lys Xaa Ile Pro Xaa Arg Glu Cys Lys Ala Leu Lys Gln Arg Pro 
                245                 250                 255     


Arg Phe Val Ala Leu Lys Lys Gln Pro Ala Tyr Leu Gly Gly Glu Asn 
            260                 265                 270         


Leu Glu Leu Arg Asp Tyr Gln Leu Glu Gly Leu Asn Trp Leu Ala His 
        275                 280                 285             


Ser Trp Cys Lys Asn Asn Ser Val Ile Leu Ala Asp Glu Met Gly Leu 
    290                 295                 300                 


Gly Lys Xaa Ile Gln Xaa Ile Ser Phe Leu Ser Tyr Leu Phe His Gln 
305                 310                 315                 320 


His Gln Leu Tyr Gly Pro Phe Leu Ile Val Val Pro Leu Ser Xaa Leu 
                325                 330                 335     


Xaa Ser Trp Gln Arg Glu Phe Glu Ile Trp Ala Pro Glu Ile Asn Val 
            340                 345                 350         


Val Val Tyr Ile Gly Asp Leu Met Ser Arg Asn Xaa Ile Arg Glu Tyr 
        355                 360                 365             


Glu Trp Ile His Ser Gln Xaa Lys Arg Leu Lys Phe Asn Ala Leu Ile 
    370                 375                 380                 


Xaa Xaa Tyr Glu Ile Leu Leu Lys Asp Lys Xaa Val Leu Gly Ser Ile 
385                 390                 395                 400 


Asn Trp Ala Phe Leu Gly Val Asp Glu Ala His Arg Leu Lys Asn Asp 
                405                 410                 415     


Asp Ser Leu Leu Tyr Lys Xaa Leu Ile Asp Phe Lys Ser Asn His Arg 
            420                 425                 430         


Leu Leu Ile Xaa Gly Xaa Pro Leu Gln Asn Ser Leu Lys Glu Leu Trp 
        435                 440                 445             


Ser Leu Leu His Phe Ile Met Pro Glu Lys Phe Glu Phe Trp Glu Asp 
    450                 455                 460                 


Phe Glu Glu Asp His Gly Lys Gly Arg Glu Asn Gly Tyr Gln Ser Leu 
465                 470                 475                 480 


His Lys Val Leu Glu Pro Phe Leu Leu Arg Arg Val Lys Lys Asp Val 
                485                 490                 495     


Glu Lys Ser Leu Pro Ala Lys Val Glu Gln Ile Leu Arg Val Glu Met 
            500                 505                 510         


Ser Ala Leu Gln Lys Gln Tyr Tyr Lys Trp Ile Leu Xaa Arg Asn Tyr 
        515                 520                 525             


Lys Ala Leu Ala Lys Gly Xaa Arg Gly Ser Xaa Ser Gly Phe Leu Asn 
    530                 535                 540                 


Ile Val Met Glu Leu Lys Lys Cys Cys Asn His Cys Tyr Leu Ile Lys 
545                 550                 555                 560 


Pro Pro Glu Glu Asn Glu Arg Glu Asn Gly Gln Glu Ile Leu Leu Ser 
                565                 570                 575     


Leu Ile Arg Ser Ser Gly Lys Leu Ile Leu Leu Asp Lys Leu Leu Xaa 
            580                 585                 590         


Arg Leu Arg Glu Arg Gly Asn Arg Val Leu Ile Phe Ser Gln Met Val 
        595                 600                 605             


Arg Met Leu Asp Ile Leu Ala Glu Tyr Leu Xaa Ile Lys His Tyr Pro 
    610                 615                 620                 


Phe Gln Arg Leu Asp Gly Ser Ile Lys Gly Glu Ile Arg Lys Gln Ala 
625                 630                 635                 640 


Leu Asp His Phe Asn Ala Asp Gly Ser Glu Asp Phe Cys Phe Leu Leu 
                645                 650                 655     


Ser Xaa Arg Ala Gly Gly Leu Gly Ile Asn Leu Ala Ser Ala Asp Xaa 
            660                 665                 670         


Val Val Ile Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu Gln Ala 
        675                 680                 685             


Gln Ala Arg Ala His Arg Ile Gly Gln Lys Lys Gln Val Asn Ile Tyr 
    690                 695                 700                 


Arg Leu Val Xaa Lys Gly Xaa Val Glu Glu Glu Ile Ile Glu Arg Ala 
705                 710                 715                 720 


Lys Lys Lys Met Val Leu Asp His Leu Val Ile Gln Arg Met Asp Xaa 
                725                 730                 735     


Xaa Gly Arg Xaa Ile Leu Glu Asn Asn Ser Gly Arg Ser Asn Ser Asn 
            740                 745                 750         


Pro Phe Asn Lys Glu Glu Leu Xaa Ala Ile Leu Lys Phe Gly Ala Glu 
        755                 760                 765             


Asp Leu Phe Lys Glu Leu Glu Gly Glu Glu Ser Glu Pro Gln Glu Met 
    770                 775                 780                 


Asp Ile Asp Glu Ile Leu Arg Leu Ala Glu Xaa Arg Glu Asn Glu Val 
785                 790                 795                 800 


Ser Xaa Ser Ala Xaa Asp Glu Leu Leu Ser Gln Phe Lys Val Ala Asn 
                805                 810                 815     


Phe Ala Xaa Met Glu Asp Glu Glu Glu Leu Glu Glu Arg Pro His Lys 
            820                 825                 830         


Asp Trp Asp Glu Ile Ile Pro Glu Glu Gln Arg Lys Lys Val Glu Glu 
        835                 840                 845             


Glu Glu Arg Gln Lys Glu Leu Glu Glu Ile Tyr Met Leu Pro Arg Ile 
    850                 855                 860                 


Arg Ser Ser Xaa Lys Lys Ala Gln Xaa Asn Asp Ser Asp Ser Asp Xaa 
865                 870                 875                 880 


Glu Ser Lys Arg Gln Ala Gln Arg Ser Ser Ala Ser Glu Ser Glu Xaa 
                885                 890                 895     


Glu Asp Ser Asp Asp Asp Lys Lys Pro Lys Arg Arg Gly Arg Pro Arg 
            900                 905                 910         


Ser Val Arg Lys Asp Leu Val Glu Gly Phe Xaa Asp Ala Glu Ile Arg 
        915                 920                 925             


Ser Ala Arg Ile Glu Ser Xaa Leu Phe Leu Xaa Ile Cys Met Ala His 
    930                 935                 940                 


Met Ser Ser Gln Asp Met Leu Ala Ser Xaa 
945                 950                 


<210> 5978
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<400> 5978
Xaa Ile Lys Trp Lys Gly Trp Ser Tyr Ile His Ser Xaa Trp Glu Ser 
1               5                   10                  15      


Glu Glu Ser Leu Gln Gln Gln Lys Val Lys Gly Leu Lys Lys Leu Glu 
            20                  25                  30          


Asn Phe Lys Lys Lys Glu Asp Glu Ile Lys Gln Trp Leu Gly Lys Val 
        35                  40                  45              


Ser Pro Glu Asp Val Glu Tyr Phe Asn Cys Gln Gln Glu Leu Ala Ser 
    50                  55                  60                  


Glu Leu Asn Lys Gln Tyr Gln Ile Val Glu Arg Val Ile Ala His Ser 
65                  70                  75                  80  


Arg Lys Pro Ala Pro Ser Asn Glu Pro Glu Tyr Leu Cys Lys Trp Met 
                85                  90                  95      


Gly Leu Pro Tyr Ser Glu Cys Ser Trp Glu Asp Glu Ala Leu Ile Gly 
            100                 105                 110         


Lys Lys Phe Gln Asn Cys Ile Asp Ser 
        115                 120     


<210> 5979
<211> 34
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<400> 5979
Xaa Ser Gln Glu Glu Glu Glu Gln Lys Lys Lys Asp Asp Val Xaa Gly 
1               5                   10                  15      


Glu Ala Ser Phe Ala Cys Leu Pro Trp Pro Xaa Asp Ala Trp Xaa Pro 
            20                  25                  30          


Lys Arg 
        


<210> 5980
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<400> 5980
Xaa Xaa Leu Gly Gln Xaa Asp Phe Pro Ala His Ser Arg Lys Pro Ala 
1               5                   10                  15      


Pro Ser Asn Glu Pro Glu Tyr Leu Cys Lys Trp Met Gly Leu Pro Tyr 
            20                  25                  30          


Ser Glu Cys Ser Trp Glu Asp Glu Ala Leu Ile Gly Lys Lys Phe Gln 
        35                  40                  45              


Asn Cys Ile Asp Ser Phe His Ser Arg Asn Asn Ser Lys Xaa Ile Pro 
    50                  55                  60                  


Xaa Arg Glu Cys Lys Val Trp 
65                  70      


<210> 5981
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(73)
<223> Selenocysteine

<400> 5981
Xaa Val Asp Pro Glu Glu Lys Lys Lys Tyr Cys Leu Xaa Cys Arg Val 
1               5                   10                  15      


Lys Ala Ala His Phe Asp Val Glu Trp Gly Val Glu Asp Asp Ser Arg 
            20                  25                  30          


Leu Leu Leu Gly Ile Tyr Glu His Gly Tyr Gly Asn Trp Glu Leu Ile 
        35                  40                  45              


Lys Xaa Asp Pro Glu Leu Lys Leu Xaa Asp Lys Leu Gln Gly Phe Pro 
    50                  55                  60                  


Ala Pro Gly Arg Arg Lys Ser Xaa Xaa Ala Gly Met Leu 
65                  70                  75          


<210> 5982
<211> 277
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<400> 5982
Phe Asn Ile Ala Asp Gly Gly Phe Xaa Glu Leu His Xaa Leu Trp Gln 
1               5                   10                  15      


Asn Glu Glu Arg Ala Ala Ile Ser Ser Gly Lys Leu Asn Glu Ile Trp 
            20                  25                  30          


His Arg Arg His Asp Tyr Trp Leu Leu Ala Gly Ile Val Leu His Gly 
        35                  40                  45              


Tyr Ala Arg Trp Gln Asp Ile Gln Asn Asp Ala Gln Phe Ala Ile Ile 
    50                  55                  60                  


Asn Glu Pro Phe Lys Xaa Glu Ala Asn Lys Gly Asn Phe Leu Glu Met 
65                  70                  75                  80  


Lys Asn Lys Phe Leu Ala Arg Arg Phe Lys Leu Leu Glu Gln Ala Leu 
                85                  90                  95      


Val Ile Glu Glu Gln Leu Arg Arg Ala Ala Tyr Leu Asn Leu Ser Gln 
            100                 105                 110         


Glu Pro Ala His Pro Ala Met Ala Leu His Ala Arg Phe Ala Glu Ala 
        115                 120                 125             


Glu Cys Leu Ala Glu Ser His Gln His Leu Ser Lys Glu Ser Leu Ala 
    130                 135                 140                 


Gly Asn Lys Pro Ala Asn Ala Val Leu His Lys Gly Leu Pro Ala Gly 
145                 150                 155                 160 


Ser Leu Arg Tyr Xaa Ser Gly Val Arg Gly Gly Leu Gln Arg Arg Xaa 
                165                 170                 175     


Arg Arg Gly Pro Gly Arg Arg Arg Arg Gln Leu Gln Pro Asp Ala Cys 
            180                 185                 190         


Arg Val Leu His His Ser Arg His Gln Arg Pro Ser Ser Ala Cys Glu 
        195                 200                 205             


Glu Gly Glu Gly Asn Gly Gly Gly Ile Gly Val Arg Arg Ala Gly Ser 
    210                 215                 220                 


Glu Gly Ala Pro Ser Arg Gly Gly Asp Leu Tyr Arg Arg Leu Xaa Gly 
225                 230                 235                 240 


Ser Gln Ala Cys Pro Ser Pro Arg Pro Arg Pro Arg Gly Arg Pro Pro 
                245                 250                 255     


Ala Gln Ala Leu Gly Pro Ala Ala Ser Pro Pro Pro Ser Pro Pro Leu 
            260                 265                 270         


Gly Pro Ser Leu Gly 
        275         


<210> 5983
<211> 383
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<400> 5983
Lys Arg Ala Glu Asp Val Lys Gly Asp Arg Glu Leu Arg Pro Gly Pro 
1               5                   10                  15      


Arg Asp Glu Pro Arg Ser Asn Gly Arg Arg Glu Glu Lys Xaa Glu Lys 
            20                  25                  30          


Pro Arg Phe Met Phe Asn Ile Ala Asp Gly Gly Phe Xaa Glu Leu His 
        35                  40                  45              


Xaa Leu Trp Gln Asn Glu Glu Arg Ala Ala Ile Ser Ser Gly Lys Leu 
    50                  55                  60                  


Asn Glu Ile Trp His Arg Arg His Asp Tyr Trp Leu Leu Ala Gly Ile 
65                  70                  75                  80  


Val Leu His Gly Tyr Ala Arg Trp Gln Asp Ile Gln Asn Asp Ala Gln 
                85                  90                  95      


Phe Ala Ile Ile Asn Glu Pro Phe Lys Xaa Glu Ala Asn Lys Gly Asn 
            100                 105                 110         


Phe Leu Glu Met Lys Asn Lys Phe Leu Ala Arg Arg Phe Lys Leu Leu 
        115                 120                 125             


Glu Gln Ala Leu Val Ile Glu Glu Gln Leu Arg Arg Ala Ala Tyr Leu 
    130                 135                 140                 


Asn Leu Ser Gln Glu Pro Ala His Pro Ala Met Ala Leu His Ala Arg 
145                 150                 155                 160 


Phe Ala Glu Ala Glu Cys Leu Ala Glu Ser His Gln His Leu Ser Lys 
                165                 170                 175     


Glu Ser Leu Ala Gly Asn Lys Pro Ala Asn Ala Val Leu His Lys Gly 
            180                 185                 190         


Lys Gly Arg Gly Gly Pro Ala Arg Gly Arg Ala His Asn Ala Ala Ser 
        195                 200                 205             


Glu Pro Ala Gly Gly Val Ala Glu Arg His Glu Gly Gly Arg Asp Pro 
    210                 215                 220                 


Pro Ala Ser His Ala Val Pro Asn Xaa Pro His Arg Ser Pro Pro Ser 
225                 230                 235                 240 


Asp Val Arg Ala Gln His Pro Gln Pro Ala Gly Gln Gln Gly His Gly 
                245                 250                 255     


Ala Ser Pro His Xaa Gly Leu Pro Ala Gly Ser Leu Arg Tyr Xaa Ser 
            260                 265                 270         


Gly Val Arg Gly Gly Leu Gln Arg Arg Xaa Arg Arg Gly Pro Gly Arg 
        275                 280                 285             


Arg Arg Arg Gln Leu Gln Pro Asp Ala Cys Arg Val Leu His His Ser 
    290                 295                 300                 


Arg His Gln Arg Pro Ser Ser Ala Cys Glu Glu Gly Glu Gly Asn Gly 
305                 310                 315                 320 


Gly Gly Ile Gly Val Arg Arg Ala Gly Ser Glu Gly Ala Pro Ser Arg 
                325                 330                 335     


Gly Gly Asp Leu Tyr Arg Arg Leu Xaa Gly Ser Gln Ala Cys Pro Ser 
            340                 345                 350         


Pro Arg Pro Arg Pro Arg Gly Arg Pro Pro Ala Gln Ala Leu Gly Pro 
        355                 360                 365             


Ala Ala Ser Pro Pro Pro Ser Pro Pro Leu Gly Pro Ser Leu Gly 
    370                 375                 380             


<210> 5984
<211> 2059
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1145)..(1145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1195)..(1195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1206)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1245)..(1245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1292)..(1292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1330)..(1330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1495)..(1496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1507)..(1507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1532)..(1532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1549)..(1549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1599)..(1600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1611)..(1611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1616)..(1616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1628)..(1628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1654)..(1654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1702)..(1702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1705)..(1705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1728)..(1728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1761)..(1761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1776)..(1776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1780)..(1780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1837)..(1837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1939)..(1939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1944)..(1944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1971)..(1971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1976)..(1976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1986)..(1986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2019)..(2019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2022)..(2022)
<223> Selenocysteine

<400> 5984
Met Ala Ser Pro Leu Arg Asp Glu Glu Glu Glu Glu Glu Glu Met Val 
1               5                   10                  15      


Val Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Asp Glu Glu Glu 
            20                  25                  30          


Glu Glu Glu Val Glu Ala Ala Asp Glu Asp Asp Glu Glu Asp Asp Asp 
        35                  40                  45              


Glu Gly Val Leu Gly Arg Gly Pro Gly His Asp Arg Gly Arg Asp Arg 
    50                  55                  60                  


His Ser Pro Pro Gly Cys His Leu Phe Pro Pro Pro Pro Pro Pro Pro 
65                  70                  75                  80  


Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Asp Lys Asp Asp 
                85                  90                  95      


Ile Arg Leu Leu Pro Ser Ala Leu Gly Val Lys Lys Arg Lys Arg Gly 
            100                 105                 110         


Pro Lys Lys Gln Lys Glu Asn Lys Pro Gly Lys Pro Arg Lys Arg Lys 
        115                 120                 125             


Lys Arg Asp Ser Glu Glu Glu Phe Gly Ser Glu Arg Asp Glu Tyr Arg 
    130                 135                 140                 


Glu Lys Ser Glu Ser Gly Gly Ser Glu Tyr Gly Xaa Gly Pro Gly Arg 
145                 150                 155                 160 


Lys Arg Arg Arg Lys His Arg Glu Lys Lys Glu Lys Lys Xaa Lys Arg 
                165                 170                 175     


Arg Lys Lys Gly Glu Gly Asp Gly Gly Gln Lys Gln Val Glu Gln Lys 
            180                 185                 190         


Ser Ser Ala Xaa Leu Leu Leu Xaa Trp Gly Leu Glu Asp Val Glu His 
        195                 200                 205             


Val Phe Ser Glu Glu Asp Tyr His Xaa Leu Xaa Asn Tyr Lys Ala Phe 
    210                 215                 220                 


Ser Gln Phe Met Arg Pro Leu Ile Ala Lys Lys Asn Pro Lys Ile Pro 
225                 230                 235                 240 


Met Ser Lys Met Met Xaa Ile Leu Gly Ala Lys Trp Arg Glu Phe Ser 
                245                 250                 255     


Ala Asn Asn Pro Phe Lys Gly Ser Ala Ala Ala Val Ala Ala Ala Ala 
            260                 265                 270         


Ala Ala Ala Ala Ala Ala Val Ala Glu Gln Val Ser Ala Ala Val Ser 
        275                 280                 285             


Ser Ala Xaa Pro Ile Ala Pro Ser Gly Pro Pro Ala Leu Pro Pro Pro 
    290                 295                 300                 


Pro Ala Ala Asp Ile Gln Pro Pro Pro Ile Arg Arg Ala Lys Xaa Lys 
305                 310                 315                 320 


Glu Gly Lys Gly Pro Gly His Lys Arg Arg Ser Lys Ser Pro Arg Val 
                325                 330                 335     


Pro Asp Gly Arg Lys Lys Leu Arg Gly Lys Lys Met Ala Pro Leu Lys 
            340                 345                 350         


Ile Lys Leu Gly Leu Leu Gly Gly Lys Arg Lys Lys Gly Gly Ser Tyr 
        355                 360                 365             


Val Phe Gln Ser Asp Glu Gly Pro Glu Pro Glu Ala Glu Glu Ser Asp 
    370                 375                 380                 


Leu Asp Ser Gly Ser Val His Ser Ala Ser Gly Arg Pro Asp Gly Pro 
385                 390                 395                 400 


Val Arg Xaa Lys Lys Leu Lys Arg Gly Arg Pro Gly Arg Lys Lys Lys 
                405                 410                 415     


Lys Val Leu Gly Cys Pro Ala Val Ala Gly Glu Glu Glu Val Asp Gly 
            420                 425                 430         


Tyr Glu Xaa Asp His Gln Asp Tyr Cys Glu Val Cys Gln Gln Gly Gly 
        435                 440                 445             


Glu Ile Ile Leu Cys Asp Xaa Cys Pro Arg Ala Tyr His Leu Val Cys 
    450                 455                 460                 


Leu Asp Pro Glu Leu Asp Arg Ala Pro Glu Gly Lys Trp Ser Cys Pro 
465                 470                 475                 480 


His Cys Glu Lys Glu Gly Val Gln Trp Glu Ala Lys Glu Glu Glu Glu 
                485                 490                 495     


Glu Tyr Glu Glu Glu Gly Glu Glu Glu Gly Glu Lys Glu Glu Glu Asp 
            500                 505                 510         


Asp His Met Glu Tyr Cys Arg Val Cys Lys Asp Gly Gly Glu Leu Leu 
        515                 520                 525             


Cys Cys Asp Ala Cys Ile Ser Ser Tyr His Ile His Cys Leu Asn Pro 
    530                 535                 540                 


Pro Leu Pro Asp Ile Pro Asn Gly Glu Trp Leu Cys Pro Arg Cys Xaa 
545                 550                 555                 560 


Cys Pro Val Leu Lys Gly Arg Val Gln Lys Ile Leu His Trp Arg Trp 
                565                 570                 575     


Gly Glu Pro Pro Val Ala Val Pro Ala Pro Gln Gln Ala Asp Gly Asn 
            580                 585                 590         


Pro Asp Val Pro Pro Pro Arg Pro Leu Gln Gly Arg Ser Glu Arg Glu 
        595                 600                 605             


Phe Phe Val Lys Trp Val Gly Leu Ser Tyr Trp His Cys Ser Trp Ala 
    610                 615                 620                 


Lys Glu Leu Gln Leu Glu Ile Phe His Leu Val Met Tyr Arg Asn Tyr 
625                 630                 635                 640 


Gln Arg Lys Asn Asp Met Asp Glu Pro Pro Pro Leu Asp Tyr Gly Ser 
                645                 650                 655     


Gly Glu Asp Asp Gly Lys Ser Asp Lys Arg Lys Val Lys Asp Pro His 
            660                 665                 670         


Tyr Ala Glu Met Glu Glu Lys Tyr Tyr Arg Phe Gly Ile Lys Pro Glu 
        675                 680                 685             


Trp Met Xaa Val His Arg Ile Ile Asn His Ser Val Asp Lys Lys Gly 
    690                 695                 700                 


Asn Tyr His Tyr Leu Val Lys Trp Arg Asp Leu Pro Tyr Asp Gln Ser 
705                 710                 715                 720 


Xaa Trp Glu Glu Asp Glu Met Asn Ile Pro Glu Tyr Glu Glu His Lys 
                725                 730                 735     


Gln Ser Tyr Trp Arg His Arg Glu Leu Ile Met Gly Glu Asp Pro Ala 
            740                 745                 750         


Gln Pro Arg Lys Tyr Lys Lys Lys Lys Lys Glu Leu Gln Gly Asp Gly 
        755                 760                 765             


Pro Pro Ser Ser Pro Xaa Asn Asp Pro Xaa Val Lys Tyr Glu Xaa Gln 
    770                 775                 780                 


Pro Arg Phe Ile Xaa Ala Xaa Gly Gly Xaa Leu His Met Tyr Gln Leu 
785                 790                 795                 800 


Glu Gly Leu Asn Trp Leu Arg Phe Ser Trp Ala Gln Gly Xaa Asp Xaa 
                805                 810                 815     


Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Xaa Ile Gln Xaa Ile Val 
            820                 825                 830         


Phe Leu Tyr Ser Leu Tyr Lys Glu Gly His Xaa Lys Gly Pro Phe Leu 
        835                 840                 845             


Val Ser Ala Pro Leu Ser Xaa Ile Ile Asn Trp Glu Arg Glu Phe Gln 
    850                 855                 860                 


Met Trp Ala Pro Lys Phe Tyr Val Val Xaa Tyr Xaa Gly Asp Lys Asp 
865                 870                 875                 880 


Ser Arg Ala Ile Ile Arg Glu Asn Glu Phe Ser Phe Glu Asp Asn Ala 
                885                 890                 895     


Ile Lys Gly Gly Lys Lys Ala Phe Lys Met Lys Arg Glu Ala Gln Val 
            900                 905                 910         


Lys Phe His Val Leu Leu Xaa Ser Tyr Glu Leu Ile Xaa Ile Asp Gln 
        915                 920                 925             


Ala Ala Leu Gly Ser Ile Arg Trp Ala Cys Leu Val Val Asp Glu Ala 
    930                 935                 940                 


His Arg Leu Lys Asn Asn Gln Ser Lys Phe Phe Arg Val Leu Asn Gly 
945                 950                 955                 960 


Tyr Lys Ile Asp His Lys Leu Leu Leu Xaa Gly Xaa Pro Leu Gln Asn 
                965                 970                 975     


Asn Leu Glu Glu Leu Phe His Leu Leu Asn Phe Leu Xaa Pro Glu Arg 
            980                 985                 990         


Phe Asn Asn Leu Glu Gly Phe Leu  Glu Glu Phe Ala Asp  Ile Ser Lys 
        995                 1000                 1005             


Glu Asp  Gln Ile Lys Lys Leu  His Asp Leu Leu Gly  Pro His Met 
    1010                 1015                 1020             


Leu Arg  Arg Leu Lys Ala Asp  Val Phe Lys Asn Met  Pro Ala Lys 
    1025                 1030                 1035             


Xaa Glu  Leu Ile Val Arg Val  Glu Leu Ser Pro Met  Gln Lys Lys 
    1040                 1045                 1050             


Tyr Tyr  Lys Tyr Ile Leu Xaa  Arg Asn Phe Glu Ala  Leu Asn Ser 
    1055                 1060                 1065             


Arg Gly  Gly Gly Asn Gln Val  Ser Leu Leu Asn Ile  Met Met Asp 
    1070                 1075                 1080             


Leu Lys  Lys Cys Cys Asn His  Pro Tyr Leu Phe Pro  Val Ala Ala 
    1085                 1090                 1095             


Met Glu  Ser Pro Lys Leu Pro  Ser Gly Ala Tyr Glu  Gly Gly Ala 
    1100                 1105                 1110             


Leu Ile  Lys Ser Ser Gly Lys  Leu Met Leu Leu Gln  Lys Met Leu 
    1115                 1120                 1125             


Arg Lys  Leu Lys Glu Gln Gly  His Arg Val Leu Ile  Phe Ser Gln 
    1130                 1135                 1140             


Met Xaa  Lys Met Leu Asp Leu  Leu Glu Asp Phe Leu  Asp Tyr Glu 
    1145                 1150                 1155             


Gly Tyr  Lys Tyr Glu Arg Ile  Asp Gly Gly Ile Xaa  Gly Ala Leu 
    1160                 1165                 1170             


Arg Gln  Glu Ala Ile Asp Arg  Phe Asn Ala Pro Gly  Ala Gln Gln 
    1175                 1180                 1185             


Phe Cys  Phe Leu Leu Ser Xaa  Arg Ala Gly Gly Leu  Gly Ile Asn 
    1190                 1195                 1200             


Leu Ala  Xaa Ala Asp Xaa Val  Ile Ile Phe Asp Ser  Asp Trp Asn 
    1205                 1210                 1215             


Pro His  Asn Asp Ile Gln Ala  Phe Ser Arg Ala His  Arg Ile Gly 
    1220                 1225                 1230             


Gln Ala  Asn Lys Val Met Ile  Tyr Arg Phe Val Xaa  Arg Ala Ser 
    1235                 1240                 1245             


Val Glu  Glu Arg Ile Xaa Gln  Val Ala Lys Arg Lys  Met Met Leu 
    1250                 1255                 1260             


Xaa His  Leu Val Val Arg Pro  Gly Leu Gly Ser Lys  Ala Gly Ser 
    1265                 1270                 1275             


Met Ser  Lys Gln Glu Leu Asp  Asp Ile Leu Lys Phe  Gly Xaa Glu 
    1280                 1285                 1290             


Glu Leu  Phe Lys Asp Glu Asn  Glu Gly Glu Asn Lys  Glu Glu Asp 
    1295                 1300                 1305             


Ser Ser  Val Ile His Tyr Asp  Asn Glu Ala Ile Ala  Arg Leu Leu 
    1310                 1315                 1320             


Asp Arg  Asn Gln Asp Ala Xaa  Glu Asp Xaa Asp Val  Gln Asn Met 
    1325                 1330                 1335             


Asn Glu  Tyr Leu Ser Ser Phe  Lys Val Ala Gln Tyr  Val Val Arg 
    1340                 1345                 1350             


Glu Glu  Asp Lys Ile Glu Glu  Ile Glu Arg Glu Ile  Ile Lys Gln 
    1355                 1360                 1365             


Glu Glu  Asn Val Asp Pro Asp  Tyr Trp Glu Lys Leu  Leu Arg His 
    1370                 1375                 1380             


His Tyr  Glu Gln Gln Gln Glu  Asp Leu Ala Arg Asn  Leu Gly Lys 
    1385                 1390                 1395             


Gly Lys  Arg Val Arg Lys Gln  Val Asn Tyr Asn Asp  Ala Ala Gln 
    1400                 1405                 1410             


Glu Asp  Gln Asp Asn Gln Ser  Glu Tyr Ser Val Gly  Ser Glu Glu 
    1415                 1420                 1425             


Glu Asp  Glu Asp Phe Asp Glu  Arg Pro Glu Gly Arg  Arg Gln Ser 
    1430                 1435                 1440             


Lys Arg  Gln Leu Arg Asn Glu  Lys Asp Lys Pro Leu  Pro Pro Leu 
    1445                 1450                 1455             


Leu Ala  Arg Val Gly Gly Asn  Ile Glu Val Leu Gly  Phe Asn Xaa 
    1460                 1465                 1470             


Arg Gln  Arg Lys Ala Phe Leu  Asn Ala Val Met Arg  Trp Gly Met 
    1475                 1480                 1485             


Pro Pro  Gln Asp Ala Phe Xaa  Xaa Gln Trp Leu Val  Arg Asp Leu 
    1490                 1495                 1500             


Arg Gly  Lys Xaa Glu Lys Glu  Phe Lys Ala Tyr Val  Ser Leu Phe 
    1505                 1510                 1515             


Met Arg  His Leu Cys Glu Pro  Gly Ala Asp Gly Ser  Glu Xaa Phe 
    1520                 1525                 1530             


Ala Asp  Gly Val Pro Arg Glu  Gly Leu Ser Arg Gln  Gln Val Leu 
    1535                 1540                 1545             


Xaa Arg  Ile Gly Val Met Ser  Leu Val Lys Lys Lys  Val Gln Glu 
    1550                 1555                 1560             


Phe Glu  His Ile Asn Gly Arg  Trp Ser Met Pro Glu  Leu Met Pro 
    1565                 1570                 1575             


Asp Pro  Ser Ala Asp Ser Lys  Arg Ser Ser Arg Ala  Ser Ser Pro 
    1580                 1585                 1590             


Xaa Lys  Xaa Ser Pro Xaa Xaa  Pro Glu Ala Ser Ala  Xaa Asn Ser 
    1595                 1600                 1605             


Pro Cys  Xaa Ser Lys Pro Ala  Xaa Pro Ala Pro Ser  Glu Lys Gly 
    1610                 1615                 1620             


Glu Gly  Ile Arg Xaa Pro Leu  Glu Lys Glu Glu Ala  Glu Asn Gln 
    1625                 1630                 1635             


Glu Glu  Lys Pro Glu Lys Asn  Ser Arg Ile Gly Glu  Lys Met Glu 
    1640                 1645                 1650             


Xaa Glu  Ala Asp Ala Pro Ser  Pro Ala Pro Ser Leu  Gly Glu Arg 
    1655                 1660                 1665             


Leu Glu  Pro Arg Lys Ile Pro  Leu Glu Asp Glu Val  Pro Gly Val 
    1670                 1675                 1680             


Pro Gly  Glu Met Glu Pro Glu  Pro Gly Tyr Arg Gly  Asp Arg Glu 
    1685                 1690                 1695             


Lys Ser  Ala Xaa Glu Ser Xaa  Pro Gly Glu Arg Gly  Glu Glu Lys 
    1700                 1705                 1710             


Pro Leu  Asp Gly Gln Glu His  Arg Glu Arg Pro Glu  Gly Glu Xaa 
    1715                 1720                 1725             


Gly Asp  Leu Gly Lys Arg Glu  Asp Val Lys Gly Asp  Arg Glu Leu 
    1730                 1735                 1740             


Arg Pro  Gly Pro Arg Asp Glu  Pro Arg Ser Asn Gly  Arg Arg Glu 
    1745                 1750                 1755             


Glu Lys  Xaa Glu Lys Pro Arg  Phe Met Phe Asn Ile  Ala Asp Gly 
    1760                 1765                 1770             


Gly Phe  Xaa Glu Leu His Xaa  Leu Trp Gln Asn Glu  Glu Arg Ala 
    1775                 1780                 1785             


Ala Ile  Ser Ser Gly Lys Leu  Asn Glu Ile Trp His  Arg Arg His 
    1790                 1795                 1800             


Asp Tyr  Trp Leu Leu Ala Gly  Ile Val Leu His Gly  Tyr Ala Arg 
    1805                 1810                 1815             


Trp Gln  Asp Ile Gln Asn Asp  Ala Gln Phe Ala Ile  Ile Asn Glu 
    1820                 1825                 1830             


Pro Phe  Lys Xaa Glu Ala Asn  Lys Gly Asn Phe Leu  Glu Met Lys 
    1835                 1840                 1845             


Asn Lys  Phe Leu Ala Arg Arg  Phe Lys Leu Leu Glu  Gln Ala Leu 
    1850                 1855                 1860             


Val Ile  Glu Glu Gln Leu Arg  Arg Ala Ala Tyr Leu  Asn Leu Ser 
    1865                 1870                 1875             


Gln Glu  Pro Ala His Pro Ala  Met Ala Leu His Ala  Arg Phe Ala 
    1880                 1885                 1890             


Glu Ala  Glu Cys Leu Ala Glu  Ser His Gln His Leu  Ser Lys Glu 
    1895                 1900                 1905             


Ser Leu  Ala Gly Asn Lys Pro  Ala Asn Ala Val Leu  His Lys Val 
    1910                 1915                 1920             


Leu Asn  Gln Leu Glu Glu Leu  Leu Ser Asp Met Lys  Ala Asp Val 
    1925                 1930                 1935             


Xaa Arg  Leu Pro Ala Xaa Leu  Ser Arg Ile Pro Pro  Ile Ala Ala 
    1940                 1945                 1950             


Arg Leu  Gln Met Ser Glu Arg  Ser Ile Leu Ser Arg  Leu Ala Ser 
    1955                 1960                 1965             


Lys Gly  Xaa Glu Pro His Pro  Xaa Pro Ala Tyr Pro  Pro Gly Pro 
    1970                 1975                 1980             


Tyr Ala  Xaa Pro Pro Gly Tyr  Gly Ala Ala Phe Ser  Ala Ala Pro 
    1985                 1990                 1995             


Val Gly  Ala Leu Ala Ala Ala  Gly Ala Asn Tyr Ser  Gln Met Pro 
    2000                 2005                 2010             


Ala Gly  Ser Phe Ile Xaa Ala  Ala Xaa Asn Gly Pro  Pro Val Leu 
    2015                 2020                 2025             


Val Lys  Lys Glu Lys Glu Met  Val Gly Ala Leu Val  Ser Asp Gly 
    2030                 2035                 2040             


Leu Asp  Arg Lys Glu Pro Arg  Ala Gly Glu Val Ile  Cys Ile Asp 
    2045                 2050                 2055             


Asp 
    


<210> 5985
<211> 1966
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1195)..(1195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1436)..(1437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1448)..(1448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1490)..(1490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1535)..(1535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1537)..(1537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1540)..(1541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1552)..(1552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1557)..(1557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1569)..(1569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1595)..(1595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1668)..(1668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1683)..(1683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1687)..(1687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1744)..(1744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1846)..(1846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1851)..(1851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1878)..(1878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1883)..(1883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1893)..(1893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1926)..(1926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1929)..(1929)
<223> Selenocysteine

<400> 5985
Met Lys Ala Ala Asp Xaa Val Ile Leu Trp Ala Arg Ser Lys Asn Asp 
1               5                   10                  15      


Gln Leu Arg Ile Ser Phe Pro Pro Gly Leu Cys Trp Gly Asp Arg Met 
            20                  25                  30          


Pro Asp Lys Asp Asp Ile Arg Leu Leu Pro Ser Ala Leu Gly Val Lys 
        35                  40                  45              


Lys Arg Lys Arg Gly Pro Lys Lys Gln Lys Glu Asn Lys Pro Gly Lys 
    50                  55                  60                  


Pro Arg Lys Arg Lys Lys Arg Asp Ser Glu Glu Glu Phe Gly Ser Glu 
65                  70                  75                  80  


Arg Asp Glu Tyr Arg Glu Lys Ser Glu Ser Gly Gly Ser Glu Tyr Gly 
                85                  90                  95      


Xaa Gly Pro Gly Arg Lys Arg Arg Arg Lys His Arg Glu Lys Lys Glu 
            100                 105                 110         


Lys Lys Xaa Lys Arg Arg Lys Lys Gly Glu Gly Asp Gly Gly Gln Lys 
        115                 120                 125             


Gln Val Glu Gln Lys Ser Ser Ala Xaa Leu Leu Leu Xaa Trp Gly Leu 
    130                 135                 140                 


Glu Asp Val Glu His Val Phe Ser Glu Glu Asp Tyr His Xaa Leu Xaa 
145                 150                 155                 160 


Asn Tyr Lys Ala Phe Ser Gln Phe Met Arg Pro Leu Ile Ala Lys Lys 
                165                 170                 175     


Asn Pro Lys Ile Pro Met Ser Lys Met Met Xaa Ile Leu Gly Ala Lys 
            180                 185                 190         


Trp Arg Glu Phe Ser Ala Asn Asn Pro Phe Lys Gly Ser Ala Ala Ala 
        195                 200                 205             


Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Glu Gln Val 
    210                 215                 220                 


Ser Ala Ala Val Ser Ser Ala Xaa Pro Ile Ala Pro Ser Gly Pro Pro 
225                 230                 235                 240 


Ala Leu Pro Pro Pro Pro Ala Ala Asp Ile Gln Pro Pro Pro Ile Arg 
                245                 250                 255     


Arg Ala Lys Xaa Lys Glu Gly Lys Gly Pro Gly His Lys Arg Arg Ser 
            260                 265                 270         


Lys Ser Pro Arg Val Pro Asp Gly Arg Lys Lys Leu Arg Gly Lys Lys 
        275                 280                 285             


Met Ala Pro Leu Lys Ile Lys Leu Gly Leu Leu Gly Gly Lys Arg Lys 
    290                 295                 300                 


Lys Gly Gly Ser Tyr Val Phe Gln Ser Asp Glu Gly Pro Glu Pro Glu 
305                 310                 315                 320 


Ala Glu Glu Ser Asp Leu Asp Ser Gly Ser Val His Ser Ala Ser Gly 
                325                 330                 335     


Arg Pro Asp Gly Pro Val Arg Xaa Lys Lys Leu Lys Arg Gly Arg Pro 
            340                 345                 350         


Gly Arg Lys Lys Lys Lys Val Leu Gly Cys Pro Ala Val Ala Gly Glu 
        355                 360                 365             


Glu Glu Val Asp Gly Tyr Glu Xaa Asp His Gln Asp Tyr Cys Glu Val 
    370                 375                 380                 


Cys Gln Gln Gly Gly Glu Ile Ile Leu Cys Asp Xaa Cys Pro Arg Ala 
385                 390                 395                 400 


Tyr His Leu Val Cys Leu Asp Pro Glu Leu Asp Arg Ala Pro Glu Gly 
                405                 410                 415     


Lys Trp Ser Cys Pro His Cys Glu Lys Glu Gly Val Gln Trp Glu Ala 
            420                 425                 430         


Lys Glu Glu Glu Glu Glu Tyr Glu Glu Glu Gly Glu Glu Glu Gly Glu 
        435                 440                 445             


Lys Glu Glu Glu Asp Asp His Met Glu Tyr Cys Arg Val Cys Lys Asp 
    450                 455                 460                 


Gly Gly Glu Leu Leu Cys Cys Asp Ala Cys Ile Ser Ser Tyr His Ile 
465                 470                 475                 480 


His Cys Leu Asn Pro Pro Leu Pro Asp Ile Pro Asn Gly Glu Trp Leu 
                485                 490                 495     


Cys Pro Arg Cys Xaa Cys Pro Val Leu Lys Gly Arg Val Gln Lys Ile 
            500                 505                 510         


Leu His Trp Arg Trp Gly Glu Pro Pro Val Ala Val Pro Ala Pro Gln 
        515                 520                 525             


Gln Ala Asp Gly Asn Pro Asp Val Pro Pro Pro Arg Pro Leu Gln Gly 
    530                 535                 540                 


Arg Ser Glu Arg Glu Phe Phe Val Lys Trp Val Gly Leu Ser Tyr Trp 
545                 550                 555                 560 


His Cys Ser Trp Ala Lys Glu Leu Gln Leu Glu Ile Phe His Leu Val 
                565                 570                 575     


Met Tyr Arg Asn Tyr Gln Arg Lys Asn Asp Met Asp Glu Pro Pro Pro 
            580                 585                 590         


Leu Asp Tyr Gly Ser Gly Glu Asp Asp Gly Lys Ser Asp Lys Arg Lys 
        595                 600                 605             


Val Lys Asp Pro His Tyr Ala Glu Met Glu Glu Lys Tyr Tyr Arg Phe 
    610                 615                 620                 


Gly Ile Lys Pro Glu Trp Met Xaa Val His Arg Ile Ile Asn His Ser 
625                 630                 635                 640 


Val Asp Lys Lys Gly Asn Tyr His Tyr Leu Val Lys Trp Arg Asp Leu 
                645                 650                 655     


Pro Tyr Asp Gln Ser Xaa Trp Glu Glu Asp Glu Met Asn Ile Pro Glu 
            660                 665                 670         


Tyr Glu Glu His Lys Gln Ser Tyr Trp Arg His Arg Glu Leu Ile Met 
        675                 680                 685             


Gly Glu Asp Pro Ala Gln Pro Arg Lys Tyr Lys Lys Lys Lys Lys Glu 
    690                 695                 700                 


Leu Gln Gly Asp Gly Pro Pro Ser Ser Pro Xaa Asn Asp Pro Xaa Val 
705                 710                 715                 720 


Lys Tyr Glu Xaa Gln Pro Arg Phe Ile Xaa Ala Xaa Gly Gly Xaa Leu 
                725                 730                 735     


His Met Tyr Gln Leu Glu Gly Leu Asn Trp Leu Arg Phe Ser Trp Ala 
            740                 745                 750         


Gln Gly Xaa Asp Xaa Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Xaa 
        755                 760                 765             


Ile Gln Xaa Ile Val Phe Leu Tyr Ser Leu Tyr Lys Glu Gly His Xaa 
    770                 775                 780                 


Lys Gly Pro Phe Leu Val Ser Ala Pro Leu Ser Xaa Ile Ile Asn Trp 
785                 790                 795                 800 


Glu Arg Glu Phe Gln Met Trp Ala Pro Lys Phe Tyr Val Val Xaa Tyr 
                805                 810                 815     


Xaa Gly Asp Lys Asp Ser Arg Ala Ile Ile Arg Glu Asn Glu Phe Ser 
            820                 825                 830         


Phe Glu Asp Asn Ala Ile Lys Gly Gly Lys Lys Ala Phe Lys Met Lys 
        835                 840                 845             


Arg Glu Ala Gln Val Lys Phe His Val Leu Leu Xaa Ser Tyr Glu Leu 
    850                 855                 860                 


Ile Xaa Ile Asp Gln Ala Ala Leu Gly Ser Ile Arg Trp Ala Cys Leu 
865                 870                 875                 880 


Val Val Asp Glu Ala His Arg Leu Lys Asn Asn Gln Ser Lys Phe Phe 
                885                 890                 895     


Arg Val Leu Asn Gly Tyr Lys Ile Asp His Lys Leu Leu Leu Xaa Gly 
            900                 905                 910         


Xaa Pro Leu Gln Asn Asn Leu Glu Glu Leu Phe His Leu Leu Asn Phe 
        915                 920                 925             


Leu Xaa Pro Glu Arg Phe Asn Asn Leu Glu Gly Phe Leu Glu Glu Phe 
    930                 935                 940                 


Ala Asp Ile Ser Lys Glu Asp Gln Ile Lys Lys Leu His Asp Leu Leu 
945                 950                 955                 960 


Gly Pro His Met Leu Arg Arg Leu Lys Ala Asp Val Phe Lys Asn Met 
                965                 970                 975     


Pro Ala Lys Xaa Glu Leu Ile Val Arg Val Glu Leu Ser Pro Met Gln 
            980                 985                 990         


Lys Lys Tyr Tyr Lys Tyr Ile Leu  Xaa Arg Asn Phe Glu  Ala Leu Asn 
        995                 1000                 1005             


Ser Arg  Gly Gly Gly Asn Gln  Val Ser Leu Leu Asn  Ile Met Met 
    1010                 1015                 1020             


Asp Leu  Lys Lys Cys Cys Asn  His Pro Tyr Leu Phe  Pro Val Ala 
    1025                 1030                 1035             


Ala Met  Glu Ser Pro Lys Leu  Pro Ser Gly Ala Tyr  Glu Gly Gly 
    1040                 1045                 1050             


Ala Leu  Ile Lys Ser Ser Gly  Lys Leu Met Leu Leu  Gln Lys Met 
    1055                 1060                 1065             


Leu Arg  Lys Leu Lys Glu Gln  Gly His Arg Val Leu  Ile Phe Ser 
    1070                 1075                 1080             


Gln Met  Xaa Lys Met Leu Asp  Leu Leu Glu Asp Phe  Leu Asp Tyr 
    1085                 1090                 1095             


Glu Gly  Tyr Lys Tyr Glu Arg  Ile Asp Gly Gly Ile  Xaa Gly Ala 
    1100                 1105                 1110             


Leu Arg  Gln Glu Ala Ile Asp  Arg Phe Asn Ala Pro  Gly Ala Gln 
    1115                 1120                 1125             


Gln Phe  Cys Phe Leu Leu Ser  Xaa Arg Ala Gly Gly  Leu Gly Ile 
    1130                 1135                 1140             


Asn Leu  Ala Xaa Ala Asp Xaa  Val Ile Ile Phe Asp  Ser Asp Trp 
    1145                 1150                 1155             


Asn Pro  His Asn Asp Ile Gln  Ala Phe Ser Arg Ala  His Arg Ile 
    1160                 1165                 1170             


Gly Gln  Ala Asn Lys Val Met  Ile Tyr Arg Phe Val  Xaa Arg Ala 
    1175                 1180                 1185             


Ser Val  Glu Glu Arg Ile Xaa  Gln Val Ala Lys Arg  Lys Met Met 
    1190                 1195                 1200             


Leu Xaa  His Leu Val Val Arg  Pro Gly Leu Gly Ser  Lys Ala Gly 
    1205                 1210                 1215             


Ser Met  Ser Lys Gln Glu Leu  Asp Asp Ile Leu Lys  Phe Gly Xaa 
    1220                 1225                 1230             


Glu Glu  Leu Phe Lys Asp Glu  Asn Glu Gly Glu Asn  Lys Glu Glu 
    1235                 1240                 1245             


Asp Ser  Ser Val Ile His Tyr  Asp Asn Glu Ala Ile  Ala Arg Leu 
    1250                 1255                 1260             


Leu Asp  Arg Asn Gln Asp Ala  Xaa Glu Asp Xaa Asp  Val Gln Asn 
    1265                 1270                 1275             


Met Asn  Glu Tyr Leu Ser Ser  Phe Lys Val Ala Gln  Tyr Val Val 
    1280                 1285                 1290             


Arg Glu  Glu Asp Lys Ile Glu  Glu Ile Glu Arg Glu  Ile Ile Lys 
    1295                 1300                 1305             


Gln Glu  Glu Asn Val Asp Pro  Asp Tyr Trp Glu Lys  Leu Leu Arg 
    1310                 1315                 1320             


His His  Tyr Glu Gln Gln Gln  Glu Asp Leu Ala Arg  Asn Leu Gly 
    1325                 1330                 1335             


Lys Gly  Lys Arg Val Arg Lys  Gln Val Asn Tyr Asn  Asp Ala Ala 
    1340                 1345                 1350             


Gln Glu  Asp Gln Asp Asn Gln  Ser Glu Tyr Ser Val  Gly Ser Glu 
    1355                 1360                 1365             


Glu Glu  Asp Glu Asp Phe Asp  Glu Arg Pro Glu Gly  Arg Arg Gln 
    1370                 1375                 1380             


Ser Lys  Arg Gln Leu Arg Asn  Glu Lys Asp Lys Pro  Leu Pro Pro 
    1385                 1390                 1395             


Leu Leu  Ala Arg Val Gly Gly  Asn Ile Glu Val Leu  Gly Phe Asn 
    1400                 1405                 1410             


Xaa Arg  Gln Arg Lys Ala Phe  Leu Asn Ala Val Met  Arg Trp Gly 
    1415                 1420                 1425             


Met Pro  Pro Gln Asp Ala Phe  Xaa Xaa Gln Trp Leu  Val Arg Asp 
    1430                 1435                 1440             


Leu Arg  Gly Lys Xaa Glu Lys  Glu Phe Lys Ala Tyr  Val Ser Leu 
    1445                 1450                 1455             


Phe Met  Arg His Leu Cys Glu  Pro Gly Ala Asp Gly  Ser Glu Xaa 
    1460                 1465                 1470             


Phe Ala  Asp Gly Val Pro Arg  Glu Gly Leu Ser Arg  Gln Gln Val 
    1475                 1480                 1485             


Leu Xaa  Arg Ile Gly Val Met  Ser Leu Val Lys Lys  Lys Val Gln 
    1490                 1495                 1500             


Glu Phe  Glu His Ile Asn Gly  Arg Trp Ser Met Pro  Glu Leu Met 
    1505                 1510                 1515             


Pro Asp  Pro Ser Ala Asp Ser  Lys Arg Ser Ser Arg  Ala Ser Ser 
    1520                 1525                 1530             


Pro Xaa  Lys Xaa Ser Pro Xaa  Xaa Pro Glu Ala Ser  Ala Xaa Asn 
    1535                 1540                 1545             


Ser Pro  Cys Xaa Ser Lys Pro  Ala Xaa Pro Ala Pro  Ser Glu Lys 
    1550                 1555                 1560             


Gly Glu  Gly Ile Arg Xaa Pro  Leu Glu Lys Glu Glu  Ala Glu Asn 
    1565                 1570                 1575             


Gln Glu  Glu Lys Pro Glu Lys  Asn Ser Arg Ile Gly  Glu Lys Met 
    1580                 1585                 1590             


Glu Xaa  Glu Ala Asp Ala Pro  Ser Pro Ala Pro Ser  Leu Gly Glu 
    1595                 1600                 1605             


Arg Leu  Glu Pro Arg Lys Ile  Pro Leu Glu Asp Glu  Val Pro Gly 
    1610                 1615                 1620             


Val Pro  Gly Glu Met Glu Pro  Glu Pro Gly Tyr Arg  Gly Asp Arg 
    1625                 1630                 1635             


Glu Lys  Ser Glu Asp Val Lys  Gly Asp Arg Glu Leu  Arg Pro Gly 
    1640                 1645                 1650             


Pro Arg  Asp Glu Pro Arg Ser  Asn Gly Arg Arg Glu  Glu Lys Xaa 
    1655                 1660                 1665             


Glu Lys  Pro Arg Phe Met Phe  Asn Ile Ala Asp Gly  Gly Phe Xaa 
    1670                 1675                 1680             


Glu Leu  His Xaa Leu Trp Gln  Asn Glu Glu Arg Ala  Ala Ile Ser 
    1685                 1690                 1695             


Ser Gly  Lys Leu Asn Glu Ile  Trp His Arg Arg His  Asp Tyr Trp 
    1700                 1705                 1710             


Leu Leu  Ala Gly Ile Val Leu  His Gly Tyr Ala Arg  Trp Gln Asp 
    1715                 1720                 1725             


Ile Gln  Asn Asp Ala Gln Phe  Ala Ile Ile Asn Glu  Pro Phe Lys 
    1730                 1735                 1740             


Xaa Glu  Ala Asn Lys Gly Asn  Phe Leu Glu Met Lys  Asn Lys Phe 
    1745                 1750                 1755             


Leu Ala  Arg Arg Phe Lys Leu  Leu Glu Gln Ala Leu  Val Ile Glu 
    1760                 1765                 1770             


Glu Gln  Leu Arg Arg Ala Ala  Tyr Leu Asn Leu Ser  Gln Glu Pro 
    1775                 1780                 1785             


Ala His  Pro Ala Met Ala Leu  His Ala Arg Phe Ala  Glu Ala Glu 
    1790                 1795                 1800             


Cys Leu  Ala Glu Ser His Gln  His Leu Ser Lys Glu  Ser Leu Ala 
    1805                 1810                 1815             


Gly Asn  Lys Pro Ala Asn Ala  Val Leu His Lys Val  Leu Asn Gln 
    1820                 1825                 1830             


Leu Glu  Glu Leu Leu Ser Asp  Met Lys Ala Asp Val  Xaa Arg Leu 
    1835                 1840                 1845             


Pro Ala  Xaa Leu Ser Arg Ile  Pro Pro Ile Ala Ala  Arg Leu Gln 
    1850                 1855                 1860             


Met Ser  Glu Arg Ser Ile Leu  Ser Arg Leu Ala Ser  Lys Gly Xaa 
    1865                 1870                 1875             


Glu Pro  His Pro Xaa Pro Ala  Tyr Pro Pro Gly Pro  Tyr Ala Xaa 
    1880                 1885                 1890             


Pro Pro  Gly Tyr Gly Ala Ala  Phe Ser Ala Ala Pro  Val Gly Ala 
    1895                 1900                 1905             


Leu Ala  Ala Ala Gly Ala Asn  Tyr Ser Gln Met Pro  Ala Gly Ser 
    1910                 1915                 1920             


Phe Ile  Xaa Ala Ala Xaa Asn  Gly Pro Pro Val Leu  Val Lys Lys 
    1925                 1930                 1935             


Glu Lys  Glu Met Val Gly Ala  Leu Val Ser Asp Gly  Leu Asp Arg 
    1940                 1945                 1950             


Lys Glu  Pro Arg Ala Gly Glu  Val Ile Cys Ile Asp  Asp 
    1955                 1960                 1965     


<210> 5986
<211> 2000
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1195)..(1195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1414)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1436)..(1437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1448)..(1448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1490)..(1490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1535)..(1535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1537)..(1537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1540)..(1541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1552)..(1552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1557)..(1557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1569)..(1569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1595)..(1595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1643)..(1643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1669)..(1669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1702)..(1702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1717)..(1717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1778)..(1778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1880)..(1880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1885)..(1885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1912)..(1912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1917)..(1917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1927)..(1927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1960)..(1960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1963)..(1963)
<223> Selenocysteine

<400> 5986
Met Lys Ala Ala Asp Xaa Val Ile Leu Trp Ala Arg Ser Lys Asn Asp 
1               5                   10                  15      


Gln Leu Arg Ile Ser Phe Pro Pro Gly Leu Cys Trp Gly Asp Arg Met 
            20                  25                  30          


Pro Asp Lys Asp Asp Ile Arg Leu Leu Pro Ser Ala Leu Gly Val Lys 
        35                  40                  45              


Lys Arg Lys Arg Gly Pro Lys Lys Gln Lys Glu Asn Lys Pro Gly Lys 
    50                  55                  60                  


Pro Arg Lys Arg Lys Lys Arg Asp Ser Glu Glu Glu Phe Gly Ser Glu 
65                  70                  75                  80  


Arg Asp Glu Tyr Arg Glu Lys Ser Glu Ser Gly Gly Ser Glu Tyr Gly 
                85                  90                  95      


Xaa Gly Pro Gly Arg Lys Arg Arg Arg Lys His Arg Glu Lys Lys Glu 
            100                 105                 110         


Lys Lys Xaa Lys Arg Arg Lys Lys Gly Glu Gly Asp Gly Gly Gln Lys 
        115                 120                 125             


Gln Val Glu Gln Lys Ser Ser Ala Xaa Leu Leu Leu Xaa Trp Gly Leu 
    130                 135                 140                 


Glu Asp Val Glu His Val Phe Ser Glu Glu Asp Tyr His Xaa Leu Xaa 
145                 150                 155                 160 


Asn Tyr Lys Ala Phe Ser Gln Phe Met Arg Pro Leu Ile Ala Lys Lys 
                165                 170                 175     


Asn Pro Lys Ile Pro Met Ser Lys Met Met Xaa Ile Leu Gly Ala Lys 
            180                 185                 190         


Trp Arg Glu Phe Ser Ala Asn Asn Pro Phe Lys Gly Ser Ala Ala Ala 
        195                 200                 205             


Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Glu Gln Val 
    210                 215                 220                 


Ser Ala Ala Val Ser Ser Ala Xaa Pro Ile Ala Pro Ser Gly Pro Pro 
225                 230                 235                 240 


Ala Leu Pro Pro Pro Pro Ala Ala Asp Ile Gln Pro Pro Pro Ile Arg 
                245                 250                 255     


Arg Ala Lys Xaa Lys Glu Gly Lys Gly Pro Gly His Lys Arg Arg Ser 
            260                 265                 270         


Lys Ser Pro Arg Val Pro Asp Gly Arg Lys Lys Leu Arg Gly Lys Lys 
        275                 280                 285             


Met Ala Pro Leu Lys Ile Lys Leu Gly Leu Leu Gly Gly Lys Arg Lys 
    290                 295                 300                 


Lys Gly Gly Ser Tyr Val Phe Gln Ser Asp Glu Gly Pro Glu Pro Glu 
305                 310                 315                 320 


Ala Glu Glu Ser Asp Leu Asp Ser Gly Ser Val His Ser Ala Ser Gly 
                325                 330                 335     


Arg Pro Asp Gly Pro Val Arg Xaa Lys Lys Leu Lys Arg Gly Arg Pro 
            340                 345                 350         


Gly Arg Lys Lys Lys Lys Val Leu Gly Cys Pro Ala Val Ala Gly Glu 
        355                 360                 365             


Glu Glu Val Asp Gly Tyr Glu Xaa Asp His Gln Asp Tyr Cys Glu Val 
    370                 375                 380                 


Cys Gln Gln Gly Gly Glu Ile Ile Leu Cys Asp Xaa Cys Pro Arg Ala 
385                 390                 395                 400 


Tyr His Leu Val Cys Leu Asp Pro Glu Leu Asp Arg Ala Pro Glu Gly 
                405                 410                 415     


Lys Trp Ser Cys Pro His Cys Glu Lys Glu Gly Val Gln Trp Glu Ala 
            420                 425                 430         


Lys Glu Glu Glu Glu Glu Tyr Glu Glu Glu Gly Glu Glu Glu Gly Glu 
        435                 440                 445             


Lys Glu Glu Glu Asp Asp His Met Glu Tyr Cys Arg Val Cys Lys Asp 
    450                 455                 460                 


Gly Gly Glu Leu Leu Cys Cys Asp Ala Cys Ile Ser Ser Tyr His Ile 
465                 470                 475                 480 


His Cys Leu Asn Pro Pro Leu Pro Asp Ile Pro Asn Gly Glu Trp Leu 
                485                 490                 495     


Cys Pro Arg Cys Xaa Cys Pro Val Leu Lys Gly Arg Val Gln Lys Ile 
            500                 505                 510         


Leu His Trp Arg Trp Gly Glu Pro Pro Val Ala Val Pro Ala Pro Gln 
        515                 520                 525             


Gln Ala Asp Gly Asn Pro Asp Val Pro Pro Pro Arg Pro Leu Gln Gly 
    530                 535                 540                 


Arg Ser Glu Arg Glu Phe Phe Val Lys Trp Val Gly Leu Ser Tyr Trp 
545                 550                 555                 560 


His Cys Ser Trp Ala Lys Glu Leu Gln Leu Glu Ile Phe His Leu Val 
                565                 570                 575     


Met Tyr Arg Asn Tyr Gln Arg Lys Asn Asp Met Asp Glu Pro Pro Pro 
            580                 585                 590         


Leu Asp Tyr Gly Ser Gly Glu Asp Asp Gly Lys Ser Asp Lys Arg Lys 
        595                 600                 605             


Val Lys Asp Pro His Tyr Ala Glu Met Glu Glu Lys Tyr Tyr Arg Phe 
    610                 615                 620                 


Gly Ile Lys Pro Glu Trp Met Xaa Val His Arg Ile Ile Asn His Ser 
625                 630                 635                 640 


Val Asp Lys Lys Gly Asn Tyr His Tyr Leu Val Lys Trp Arg Asp Leu 
                645                 650                 655     


Pro Tyr Asp Gln Ser Xaa Trp Glu Glu Asp Glu Met Asn Ile Pro Glu 
            660                 665                 670         


Tyr Glu Glu His Lys Gln Ser Tyr Trp Arg His Arg Glu Leu Ile Met 
        675                 680                 685             


Gly Glu Asp Pro Ala Gln Pro Arg Lys Tyr Lys Lys Lys Lys Lys Glu 
    690                 695                 700                 


Leu Gln Gly Asp Gly Pro Pro Ser Ser Pro Xaa Asn Asp Pro Xaa Val 
705                 710                 715                 720 


Lys Tyr Glu Xaa Gln Pro Arg Phe Ile Xaa Ala Xaa Gly Gly Xaa Leu 
                725                 730                 735     


His Met Tyr Gln Leu Glu Gly Leu Asn Trp Leu Arg Phe Ser Trp Ala 
            740                 745                 750         


Gln Gly Xaa Asp Xaa Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Xaa 
        755                 760                 765             


Ile Gln Xaa Ile Val Phe Leu Tyr Ser Leu Tyr Lys Glu Gly His Xaa 
    770                 775                 780                 


Lys Gly Pro Phe Leu Val Ser Ala Pro Leu Ser Xaa Ile Ile Asn Trp 
785                 790                 795                 800 


Glu Arg Glu Phe Gln Met Trp Ala Pro Lys Phe Tyr Val Val Xaa Tyr 
                805                 810                 815     


Xaa Gly Asp Lys Asp Ser Arg Ala Ile Ile Arg Glu Asn Glu Phe Ser 
            820                 825                 830         


Phe Glu Asp Asn Ala Ile Lys Gly Gly Lys Lys Ala Phe Lys Met Lys 
        835                 840                 845             


Arg Glu Ala Gln Val Lys Phe His Val Leu Leu Xaa Ser Tyr Glu Leu 
    850                 855                 860                 


Ile Xaa Ile Asp Gln Ala Ala Leu Gly Ser Ile Arg Trp Ala Cys Leu 
865                 870                 875                 880 


Val Val Asp Glu Ala His Arg Leu Lys Asn Asn Gln Ser Lys Phe Phe 
                885                 890                 895     


Arg Val Leu Asn Gly Tyr Lys Ile Asp His Lys Leu Leu Leu Xaa Gly 
            900                 905                 910         


Xaa Pro Leu Gln Asn Asn Leu Glu Glu Leu Phe His Leu Leu Asn Phe 
        915                 920                 925             


Leu Xaa Pro Glu Arg Phe Asn Asn Leu Glu Gly Phe Leu Glu Glu Phe 
    930                 935                 940                 


Ala Asp Ile Ser Lys Glu Asp Gln Ile Lys Lys Leu His Asp Leu Leu 
945                 950                 955                 960 


Gly Pro His Met Leu Arg Arg Leu Lys Ala Asp Val Phe Lys Asn Met 
                965                 970                 975     


Pro Ala Lys Xaa Glu Leu Ile Val Arg Val Glu Leu Ser Pro Met Gln 
            980                 985                 990         


Lys Lys Tyr Tyr Lys Tyr Ile Leu  Xaa Arg Asn Phe Glu  Ala Leu Asn 
        995                 1000                 1005             


Ser Arg  Gly Gly Gly Asn Gln  Val Ser Leu Leu Asn  Ile Met Met 
    1010                 1015                 1020             


Asp Leu  Lys Lys Cys Cys Asn  His Pro Tyr Leu Phe  Pro Val Ala 
    1025                 1030                 1035             


Ala Met  Glu Ser Pro Lys Leu  Pro Ser Gly Ala Tyr  Glu Gly Gly 
    1040                 1045                 1050             


Ala Leu  Ile Lys Ser Ser Gly  Lys Leu Met Leu Leu  Gln Lys Met 
    1055                 1060                 1065             


Leu Arg  Lys Leu Lys Glu Gln  Gly His Arg Val Leu  Ile Phe Ser 
    1070                 1075                 1080             


Gln Met  Xaa Lys Met Leu Asp  Leu Leu Glu Asp Phe  Leu Asp Tyr 
    1085                 1090                 1095             


Glu Gly  Tyr Lys Tyr Glu Arg  Ile Asp Gly Gly Ile  Xaa Gly Ala 
    1100                 1105                 1110             


Leu Arg  Gln Glu Ala Ile Asp  Arg Phe Asn Ala Pro  Gly Ala Gln 
    1115                 1120                 1125             


Gln Phe  Cys Phe Leu Leu Ser  Xaa Arg Ala Gly Gly  Leu Gly Ile 
    1130                 1135                 1140             


Asn Leu  Ala Xaa Ala Asp Xaa  Val Ile Ile Phe Asp  Ser Asp Trp 
    1145                 1150                 1155             


Asn Pro  His Asn Asp Ile Gln  Ala Phe Ser Arg Ala  His Arg Ile 
    1160                 1165                 1170             


Gly Gln  Ala Asn Lys Val Met  Ile Tyr Arg Phe Val  Xaa Arg Ala 
    1175                 1180                 1185             


Ser Val  Glu Glu Arg Ile Xaa  Gln Val Ala Lys Arg  Lys Met Met 
    1190                 1195                 1200             


Leu Xaa  His Leu Val Val Arg  Pro Gly Leu Gly Ser  Lys Ala Gly 
    1205                 1210                 1215             


Ser Met  Ser Lys Gln Glu Leu  Asp Asp Ile Leu Lys  Phe Gly Xaa 
    1220                 1225                 1230             


Glu Glu  Leu Phe Lys Asp Glu  Asn Glu Gly Glu Asn  Lys Glu Glu 
    1235                 1240                 1245             


Asp Ser  Ser Val Ile His Tyr  Asp Asn Glu Ala Ile  Ala Arg Leu 
    1250                 1255                 1260             


Leu Asp  Arg Asn Gln Asp Ala  Xaa Glu Asp Xaa Asp  Val Gln Asn 
    1265                 1270                 1275             


Met Asn  Glu Tyr Leu Ser Ser  Phe Lys Val Ala Gln  Tyr Val Val 
    1280                 1285                 1290             


Arg Glu  Glu Asp Lys Ile Glu  Glu Ile Glu Arg Glu  Ile Ile Lys 
    1295                 1300                 1305             


Gln Glu  Glu Asn Val Asp Pro  Asp Tyr Trp Glu Lys  Leu Leu Arg 
    1310                 1315                 1320             


His His  Tyr Glu Gln Gln Gln  Glu Asp Leu Ala Arg  Asn Leu Gly 
    1325                 1330                 1335             


Lys Gly  Lys Arg Val Arg Lys  Gln Val Asn Tyr Asn  Asp Ala Ala 
    1340                 1345                 1350             


Gln Glu  Asp Gln Asp Asn Gln  Ser Glu Tyr Ser Val  Gly Ser Glu 
    1355                 1360                 1365             


Glu Glu  Asp Glu Asp Phe Asp  Glu Arg Pro Glu Gly  Arg Arg Gln 
    1370                 1375                 1380             


Ser Lys  Arg Gln Leu Arg Asn  Glu Lys Asp Lys Pro  Leu Pro Pro 
    1385                 1390                 1395             


Leu Leu  Ala Arg Val Gly Gly  Asn Ile Glu Val Leu  Gly Phe Asn 
    1400                 1405                 1410             


Xaa Arg  Gln Arg Lys Ala Phe  Leu Asn Ala Val Met  Arg Trp Gly 
    1415                 1420                 1425             


Met Pro  Pro Gln Asp Ala Phe  Xaa Xaa Gln Trp Leu  Val Arg Asp 
    1430                 1435                 1440             


Leu Arg  Gly Lys Xaa Glu Lys  Glu Phe Lys Ala Tyr  Val Ser Leu 
    1445                 1450                 1455             


Phe Met  Arg His Leu Cys Glu  Pro Gly Ala Asp Gly  Ser Glu Xaa 
    1460                 1465                 1470             


Phe Ala  Asp Gly Val Pro Arg  Glu Gly Leu Ser Arg  Gln Gln Val 
    1475                 1480                 1485             


Leu Xaa  Arg Ile Gly Val Met  Ser Leu Val Lys Lys  Lys Val Gln 
    1490                 1495                 1500             


Glu Phe  Glu His Ile Asn Gly  Arg Trp Ser Met Pro  Glu Leu Met 
    1505                 1510                 1515             


Pro Asp  Pro Ser Ala Asp Ser  Lys Arg Ser Ser Arg  Ala Ser Ser 
    1520                 1525                 1530             


Pro Xaa  Lys Xaa Ser Pro Xaa  Xaa Pro Glu Ala Ser  Ala Xaa Asn 
    1535                 1540                 1545             


Ser Pro  Cys Xaa Ser Lys Pro  Ala Xaa Pro Ala Pro  Ser Glu Lys 
    1550                 1555                 1560             


Gly Glu  Gly Ile Arg Xaa Pro  Leu Glu Lys Glu Glu  Ala Glu Asn 
    1565                 1570                 1575             


Gln Glu  Glu Lys Pro Glu Lys  Asn Ser Arg Ile Gly  Glu Lys Met 
    1580                 1585                 1590             


Glu Xaa  Glu Ala Asp Ala Pro  Ser Pro Ala Pro Ser  Leu Gly Glu 
    1595                 1600                 1605             


Arg Leu  Glu Pro Arg Lys Ile  Pro Leu Glu Asp Glu  Val Pro Gly 
    1610                 1615                 1620             


Val Pro  Gly Glu Met Glu Pro  Glu Pro Gly Tyr Arg  Gly Asp Arg 
    1625                 1630                 1635             


Glu Lys  Ser Ala Xaa Glu Ser  Xaa Pro Gly Glu Arg  Gly Glu Glu 
    1640                 1645                 1650             


Lys Pro  Leu Asp Gly Gln Glu  His Arg Glu Arg Pro  Glu Gly Glu 
    1655                 1660                 1665             


Xaa Gly  Asp Leu Gly Lys Arg  Glu Asp Val Lys Gly  Asp Arg Glu 
    1670                 1675                 1680             


Leu Arg  Pro Gly Pro Arg Asp  Glu Pro Arg Ser Asn  Gly Arg Arg 
    1685                 1690                 1695             


Glu Glu  Lys Xaa Glu Lys Pro  Arg Phe Met Phe Asn  Ile Ala Asp 
    1700                 1705                 1710             


Gly Gly  Phe Xaa Glu Leu His  Xaa Leu Trp Gln Asn  Glu Glu Arg 
    1715                 1720                 1725             


Ala Ala  Ile Ser Ser Gly Lys  Leu Asn Glu Ile Trp  His Arg Arg 
    1730                 1735                 1740             


His Asp  Tyr Trp Leu Leu Ala  Gly Ile Val Leu His  Gly Tyr Ala 
    1745                 1750                 1755             


Arg Trp  Gln Asp Ile Gln Asn  Asp Ala Gln Phe Ala  Ile Ile Asn 
    1760                 1765                 1770             


Glu Pro  Phe Lys Xaa Glu Ala  Asn Lys Gly Asn Phe  Leu Glu Met 
    1775                 1780                 1785             


Lys Asn  Lys Phe Leu Ala Arg  Arg Phe Lys Leu Leu  Glu Gln Ala 
    1790                 1795                 1800             


Leu Val  Ile Glu Glu Gln Leu  Arg Arg Ala Ala Tyr  Leu Asn Leu 
    1805                 1810                 1815             


Ser Gln  Glu Pro Ala His Pro  Ala Met Ala Leu His  Ala Arg Phe 
    1820                 1825                 1830             


Ala Glu  Ala Glu Cys Leu Ala  Glu Ser His Gln His  Leu Ser Lys 
    1835                 1840                 1845             


Glu Ser  Leu Ala Gly Asn Lys  Pro Ala Asn Ala Val  Leu His Lys 
    1850                 1855                 1860             


Val Leu  Asn Gln Leu Glu Glu  Leu Leu Ser Asp Met  Lys Ala Asp 
    1865                 1870                 1875             


Val Xaa  Arg Leu Pro Ala Xaa  Leu Ser Arg Ile Pro  Pro Ile Ala 
    1880                 1885                 1890             


Ala Arg  Leu Gln Met Ser Glu  Arg Ser Ile Leu Ser  Arg Leu Ala 
    1895                 1900                 1905             


Ser Lys  Gly Xaa Glu Pro His  Pro Xaa Pro Ala Tyr  Pro Pro Gly 
    1910                 1915                 1920             


Pro Tyr  Ala Xaa Pro Pro Gly  Tyr Gly Ala Ala Phe  Ser Ala Ala 
    1925                 1930                 1935             


Pro Val  Gly Ala Leu Ala Ala  Ala Gly Ala Asn Tyr  Ser Gln Met 
    1940                 1945                 1950             


Pro Ala  Gly Ser Phe Ile Xaa  Ala Ala Xaa Asn Gly  Pro Pro Val 
    1955                 1960                 1965             


Leu Val  Lys Lys Glu Lys Glu  Met Val Gly Ala Leu  Val Ser Asp 
    1970                 1975                 1980             


Gly Leu  Asp Arg Lys Glu Pro  Arg Ala Gly Glu Val  Ile Cys Ile 
    1985                 1990                 1995             


Asp Asp  
    2000 


<210> 5987
<211> 250
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<400> 5987
Arg Glu Leu Arg Pro Gly Pro Arg Asp Glu Pro Arg Ser Asn Gly Arg 
1               5                   10                  15      


Arg Glu Glu Lys Xaa Glu Lys Pro Arg Phe Met Phe Asn Ile Ala Asp 
            20                  25                  30          


Gly Gly Phe Xaa Glu Leu His Xaa Leu Trp Gln Asn Glu Glu Arg Ala 
        35                  40                  45              


Ala Ile Ser Ser Gly Lys Leu Asn Glu Ile Trp His Arg Arg His Asp 
    50                  55                  60                  


Tyr Trp Leu Leu Ala Gly Ile Val Leu His Gly Tyr Ala Arg Trp Gln 
65                  70                  75                  80  


Asp Ile Gln Asn Asp Ala Gln Phe Ala Ile Ile Asn Glu Pro Phe Lys 
                85                  90                  95      


Xaa Glu Ala Asn Lys Gly Asn Phe Leu Glu Met Lys Asn Lys Phe Leu 
            100                 105                 110         


Ala Arg Arg Phe Lys Leu Leu Glu Gln Ala Leu Val Ile Glu Glu Gln 
        115                 120                 125             


Leu Arg Arg Ala Ala Tyr Leu Asn Leu Ser Gln Glu Pro Ala His Pro 
    130                 135                 140                 


Ala Met Ala Leu His Ala Arg Phe Ala Glu Ala Glu Cys Leu Ala Glu 
145                 150                 155                 160 


Ser His Gln His Leu Ser Lys Glu Ser Leu Ala Gly Asn Lys Pro Ala 
                165                 170                 175     


Asn Ala Val Leu His Lys Ala Gly Gly Val Ala Glu Arg His Glu Gly 
            180                 185                 190         


Gly Arg Asp Pro Pro Ala Ser His Ala Val Pro Asn Xaa Pro His Arg 
        195                 200                 205             


Ser Pro Pro Ser Asp Val Arg Ala Gln His Pro Gln Pro Ala Gly Gln 
    210                 215                 220                 


Gln Gly His Gly Ala Ser Pro His Xaa Gly Leu Pro Ala Gly Ser Leu 
225                 230                 235                 240 


Arg Tyr Xaa Ser Gly Val Arg Gly Gly Leu 
                245                 250 


<210> 5988
<211> 63
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<400> 5988
Ser Val Ile His Tyr Asp Asn Glu Ala Ile Ala Arg Leu Leu Asp Arg 
1               5                   10                  15      


Asn Gln Asp Ala Xaa Glu Asp Xaa Asp Val Gln Asn Met Asn Glu Tyr 
            20                  25                  30          


Leu Ser Ser Phe Lys Val Ala Gln Tyr Val Val Arg Glu Glu Asp Lys 
        35                  40                  45              


Val Arg Leu Asp Phe Arg Glu Lys Arg Arg His Arg Gln Tyr Trp 
    50                  55                  60              


<210> 5989
<211> 525
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<400> 5989
Xaa Gln Lys Gln Val Glu Gln Lys Ser Ser Ala Xaa Leu Leu Leu Xaa 
1               5                   10                  15      


Trp Gly Leu Glu Asp Val Glu His Val Phe Ser Glu Glu Asp Tyr His 
            20                  25                  30          


Xaa Leu Xaa Asn Tyr Lys Ala Phe Ser Gln Phe Met Arg Pro Leu Ile 
        35                  40                  45              


Ala Lys Lys Asn Pro Lys Ile Pro Met Ser Lys Met Met Xaa Ile Leu 
    50                  55                  60                  


Gly Ala Lys Trp Arg Glu Phe Ser Ala Asn Asn Pro Phe Lys Gly Ser 
65                  70                  75                  80  


Ala Ala Ala Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ala 
                85                  90                  95      


Glu Gln Val Ser Ala Ala Val Ser Ser Ala Xaa Pro Ile Ala Pro Ser 
            100                 105                 110         


Gly Pro Pro Ala Leu Pro Pro Pro Pro Ala Ala Asp Ile Gln Pro Pro 
        115                 120                 125             


Pro Ile Arg Arg Ala Lys Xaa Lys Glu Gly Lys Gly Pro Gly His Lys 
    130                 135                 140                 


Arg Arg Ser Lys Ser Pro Arg Val Pro Asp Gly Arg Lys Lys Leu Arg 
145                 150                 155                 160 


Gly Lys Lys Met Ala Pro Leu Lys Ile Lys Leu Gly Leu Leu Gly Gly 
                165                 170                 175     


Lys Arg Lys Lys Gly Gly Ser Ser Asp Glu Gly Pro Glu Pro Glu Ala 
            180                 185                 190         


Glu Glu Ser Asp Leu Asp Ser Gly Ser Val His Ser Ala Ser Gly Arg 
        195                 200                 205             


Pro Asp Gly Pro Val Arg Xaa Lys Lys Leu Lys Arg Gly Arg Pro Gly 
    210                 215                 220                 


Arg Lys Lys Lys Lys Val Leu Gly Cys Pro Ala Val Ala Gly Glu Glu 
225                 230                 235                 240 


Glu Val Asp Gly Tyr Glu Xaa Asp His Gln Asp Tyr Cys Glu Val Cys 
                245                 250                 255     


Gln Gln Gly Gly Glu Ile Ile Leu Cys Asp Xaa Cys Pro Arg Ala Tyr 
            260                 265                 270         


His Leu Val Cys Leu Asp Pro Glu Leu Asp Arg Ala Pro Glu Gly Lys 
        275                 280                 285             


Trp Ser Cys Pro His Cys Glu Lys Glu Gly Val Gln Trp Glu Ala Lys 
    290                 295                 300                 


Glu Glu Glu Glu Glu Tyr Glu Glu Glu Gly Glu Glu Glu Gly Glu Lys 
305                 310                 315                 320 


Glu Glu Glu Asp Asp His Met Glu Tyr Cys Arg Val Cys Lys Asp Gly 
                325                 330                 335     


Gly Glu Leu Leu Cys Cys Asp Ala Cys Ile Ser Ser Tyr His Ile His 
            340                 345                 350         


Cys Leu Asn Pro Pro Leu Pro Asp Ile Pro Asn Gly Glu Trp Leu Cys 
        355                 360                 365             


Pro Arg Cys Xaa Cys Pro Val Leu Lys Gly Arg Val Gln Lys Ile Leu 
    370                 375                 380                 


His Trp Arg Trp Gly Glu Pro Pro Val Ala Val Pro Ala Pro Gln Gln 
385                 390                 395                 400 


Ala Asp Gly Asn Pro Asp Val Pro Pro Pro Arg Pro Leu Gln Gly Arg 
                405                 410                 415     


Ser Glu Arg Glu Phe Phe Val Lys Trp Val Gly Leu Ser Tyr Trp His 
            420                 425                 430         


Cys Ser Trp Ala Lys Glu Leu Gln Leu Glu Ile Phe His Leu Val Met 
        435                 440                 445             


Tyr Arg Asn Tyr Gln Arg Lys Asn Asp Met Asp Glu Pro Pro Pro Leu 
    450                 455                 460                 


Asp Tyr Gly Ser Gly Glu Asp Asp Gly Lys Ser Asp Lys Arg Lys Val 
465                 470                 475                 480 


Lys Asp Pro His Tyr Ala Glu Met Glu Glu Lys Tyr Tyr Arg Phe Gly 
                485                 490                 495     


Ile Lys Pro Glu Trp Met Xaa Val His Arg Ile Ile Asn His Ser Val 
            500                 505                 510         


Asp Lys Lys Gly Asn Tyr His Tyr Leu Val Lys Trp Arg 
        515                 520                 525 


<210> 5990
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 5990
Xaa Ser Pro Arg Val Pro Asp Gly Arg Lys Lys Leu Arg Gly Lys Lys 
1               5                   10                  15      


Met Ala Pro Leu Lys Ile Lys Leu Gly Leu Leu Gly Gly Lys Arg Lys 
            20                  25                  30          


Lys Gly Gly Ser Tyr Val Phe Gln Ser Asp Glu Gly Pro Glu Pro Glu 
        35                  40                  45              


Ala Glu Glu Ser Asp Leu Asp Ser Gly Ser Val His Ser Ala Ser Gly 
    50                  55                  60                  


Arg Pro Asp Gly Pro Val Arg Xaa Lys Lys Leu Lys Arg Gly Arg Pro 
65                  70                  75                  80  


Gly Arg Lys Lys Lys Lys Val Ala Gly Glu Glu Glu Val Asp Gly Tyr 
                85                  90                  95      


Glu Xaa Asp His Gln Asp Tyr Cys Glu Val Cys Gln Gln Gly 
            100                 105                 110 


<210> 5991
<211> 1937
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1123)..(1123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1173)..(1173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1192)..(1192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1262)..(1262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1365)..(1365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1465)..(1466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1502)..(1502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1519)..(1519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1565)..(1565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1567)..(1567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1570)..(1570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1578)..(1578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1611)..(1611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1615)..(1615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1620)..(1620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1652)..(1652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1658)..(1658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1678)..(1678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1704)..(1704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1731)..(1731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1745)..(1745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1747)..(1747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1750)..(1750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1845)..(1845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1894)..(1894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1899)..(1899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1929)..(1929)
<223> Selenocysteine

<400> 5991
Met Ala Ser Gly Leu Gly Ser Pro Ser Pro Cys Ser Ala Gly Ser Glu 
1               5                   10                  15      


Glu Glu Asp Met Asp Ala Leu Leu Asn Asn Ser Leu Pro Pro Pro His 
            20                  25                  30          


Pro Glu Asp Pro Glu Glu Asp Leu Ser Glu Xaa Glu Xaa Pro Lys Leu 
        35                  40                  45              


Lys Lys Lys Lys Lys Pro Lys Lys Pro Arg Asp Pro Lys Ile Pro Lys 
    50                  55                  60                  


Ser Lys Arg Gln Lys Lys Glu Arg Met Leu Leu Cys Arg Gln Leu Gly 
65                  70                  75                  80  


Asp Ser Ser Gly Glu Gly Pro Glu Phe Val Glu Glu Glu Glu Glu Val 
                85                  90                  95      


Ala Leu Arg Ser Asp Ser Glu Gly Ser Asp Tyr Xaa Pro Gly Lys Lys 
            100                 105                 110         


Lys Lys Lys Lys Leu Gly Pro Lys Lys Glu Lys Lys Ser Lys Ser Lys 
        115                 120                 125             


Arg Lys Glu Glu Glu Glu Glu Glu Asp Asp Asp Asp Asp Ser Lys Glu 
    130                 135                 140                 


Pro Lys Ser Ser Ala Gln Leu Leu Glu Asp Trp Gly Met Glu Asp Ile 
145                 150                 155                 160 


Asp His Val Phe Ser Glu Glu Asp Tyr Arg Xaa Leu Xaa Asn Tyr Lys 
                165                 170                 175     


Ala Phe Ser Gln Phe Val Arg Pro Leu Ile Ala Ala Lys Asn Pro Lys 
            180                 185                 190         


Ile Ala Val Ser Lys Met Met Met Val Leu Gly Ala Lys Trp Arg Glu 
        195                 200                 205             


Phe Ser Xaa Asn Asn Pro Phe Lys Gly Ser Ser Gly Ala Ser Val Ala 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Val Ala Val Val Glu Ser Met Val Xaa Ala 
225                 230                 235                 240 


Xaa Glu Val Ala Pro Pro Pro Pro Pro Val Glu Val Pro Ile Arg Lys 
                245                 250                 255     


Ala Lys Xaa Lys Glu Gly Lys Gly Pro Asn Ala Arg Arg Lys Pro Lys 
            260                 265                 270         


Gly Ser Pro Arg Val Pro Asp Ala Lys Lys Pro Lys Pro Lys Lys Val 
        275                 280                 285             


Ala Pro Leu Lys Ile Lys Leu Gly Gly Phe Gly Ser Lys Arg Lys Arg 
    290                 295                 300                 


Ser Ser Ser Glu Asp Asp Asp Leu Asp Val Glu Ser Asp Phe Asp Asp 
305                 310                 315                 320 


Ala Ser Ile Asn Ser Tyr Ser Val Ser Asp Gly Ser Xaa Ser Arg Ser 
                325                 330                 335     


Ser Arg Ser Arg Lys Lys Leu Arg Xaa Xaa Lys Lys Lys Lys Lys Gly 
            340                 345                 350         


Glu Glu Glu Val Xaa Ala Val Asp Gly Tyr Glu Xaa Asp His Gln Asp 
        355                 360                 365             


Tyr Cys Glu Val Cys Gln Gln Gly Gly Glu Ile Ile Leu Cys Asp Xaa 
    370                 375                 380                 


Cys Pro Arg Ala Tyr His Met Val Cys Leu Asp Pro Asp Met Glu Lys 
385                 390                 395                 400 


Ala Pro Glu Gly Lys Trp Ser Cys Pro His Cys Glu Lys Glu Gly Ile 
                405                 410                 415     


Gln Trp Glu Ala Lys Glu Asp Asn Ser Glu Gly Glu Glu Ile Leu Glu 
            420                 425                 430         


Glu Val Gly Gly Asp Leu Glu Glu Glu Asp Asp His His Met Glu Phe 
        435                 440                 445             


Cys Arg Val Cys Lys Asp Gly Gly Glu Leu Leu Cys Cys Asp Xaa Cys 
    450                 455                 460                 


Pro Ser Ser Tyr His Ile His Cys Leu Asn Pro Pro Leu Pro Glu Ile 
465                 470                 475                 480 


Pro Asn Gly Glu Trp Leu Cys Pro Arg Cys Xaa Cys Pro Ala Leu Lys 
                485                 490                 495     


Gly Lys Val Gln Lys Ile Leu Ile Trp Lys Trp Gly Gln Pro Pro Ser 
            500                 505                 510         


Pro Xaa Pro Val Pro Arg Pro Pro Asp Ala Asp Pro Asn Xaa Pro Ser 
        515                 520                 525             


Pro Lys Pro Leu Glu Gly Arg Pro Glu Arg Gln Phe Phe Val Lys Trp 
    530                 535                 540                 


Gln Gly Met Ser Tyr Trp His Cys Ser Trp Val Ser Glu Leu Gln Leu 
545                 550                 555                 560 


Glu Leu His Cys Gln Val Met Phe Arg Asn Tyr Gln Arg Lys Asn Asp 
                565                 570                 575     


Met Asp Glu Pro Pro Ser Gly Asp Phe Gly Gly Asp Glu Glu Lys Ser 
            580                 585                 590         


Arg Lys Arg Lys Asn Lys Asp Pro Lys Phe Ala Glu Met Glu Glu Arg 
        595                 600                 605             


Phe Tyr Arg Tyr Gly Ile Lys Pro Glu Trp Met Met Ile His Arg Ile 
    610                 615                 620                 


Leu Asn His Ser Val Asp Lys Lys Gly His Val His Tyr Leu Ile Lys 
625                 630                 635                 640 


Trp Arg Asp Leu Pro Tyr Asp Gln Ala Ser Trp Glu Ser Glu Asp Val 
                645                 650                 655     


Glu Ile Gln Asp Tyr Asp Leu Phe Lys Gln Ser Tyr Trp Asn His Arg 
            660                 665                 670         


Glu Leu Met Arg Gly Glu Glu Gly Arg Pro Gly Lys Lys Leu Lys Lys 
        675                 680                 685             


Val Lys Leu Arg Lys Leu Glu Arg Pro Pro Glu Xaa Pro Xaa Val Asp 
    690                 695                 700                 


Pro Xaa Val Lys Tyr Glu Arg Gln Pro Glu Tyr Leu Asp Ala Xaa Gly 
705                 710                 715                 720 


Gly Xaa Leu His Pro Tyr Gln Met Glu Gly Leu Asn Trp Leu Arg Phe 
                725                 730                 735     


Ser Trp Ala Gln Gly Xaa Asp Xaa Ile Leu Ala Asp Glu Met Gly Leu 
            740                 745                 750         


Gly Lys Xaa Val Gln Xaa Ala Val Phe Leu Tyr Ser Leu Tyr Lys Glu 
        755                 760                 765             


Gly His Ser Lys Gly Pro Phe Leu Val Ser Ala Pro Leu Ser Xaa Ile 
    770                 775                 780                 


Ile Asn Trp Glu Arg Glu Phe Glu Met Trp Ala Pro Asp Met Tyr Val 
785                 790                 795                 800 


Val Xaa Tyr Val Gly Asp Lys Asp Ser Arg Ala Ile Ile Arg Glu Asn 
                805                 810                 815     


Glu Phe Ser Phe Glu Asp Asn Ala Ile Arg Gly Gly Lys Lys Ala Ser 
            820                 825                 830         


Arg Met Lys Lys Glu Ala Ser Val Lys Phe His Val Leu Leu Xaa Ser 
        835                 840                 845             


Tyr Glu Leu Ile Xaa Ile Asp Met Ala Ile Leu Gly Ser Ile Asp Trp 
    850                 855                 860                 


Ala Cys Leu Ile Val Asp Glu Ala His Arg Leu Lys Asn Asn Gln Ser 
865                 870                 875                 880 


Lys Phe Phe Arg Val Leu Asn Gly Tyr Ser Leu Gln His Lys Leu Leu 
                885                 890                 895     


Leu Xaa Gly Xaa Pro Leu Gln Asn Asn Leu Glu Glu Leu Phe His Leu 
            900                 905                 910         


Leu Asn Phe Leu Xaa Pro Glu Arg Phe His Asn Leu Glu Gly Phe Leu 
        915                 920                 925             


Glu Glu Phe Ala Asp Ile Ala Lys Glu Asp Gln Ile Lys Lys Leu His 
    930                 935                 940                 


Asp Met Leu Gly Pro His Met Leu Arg Arg Leu Lys Ala Asp Val Phe 
945                 950                 955                 960 


Lys Asn Met Pro Ser Lys Xaa Glu Leu Ile Val Arg Val Glu Leu Ser 
                965                 970                 975     


Pro Met Gln Lys Lys Tyr Tyr Lys Tyr Ile Leu Xaa Arg Asn Phe Glu 
            980                 985                 990         


Ala Leu Asn Ala Arg Gly Gly Gly  Asn Gln Val Ser Leu  Leu Asn Val 
        995                 1000                 1005             


Val Met  Asp Leu Lys Lys Cys  Cys Asn His Pro Tyr  Leu Phe Pro 
    1010                 1015                 1020             


Val Ala  Ala Met Glu Ala Pro  Lys Met Pro Asn Gly  Met Tyr Asp 
    1025                 1030                 1035             


Gly Ser  Ala Leu Ile Arg Ala  Ser Gly Lys Leu Leu  Leu Leu Gln 
    1040                 1045                 1050             


Lys Met  Leu Lys Asn Leu Lys  Glu Gly Gly His Arg  Val Leu Ile 
    1055                 1060                 1065             


Phe Ser  Gln Met Xaa Lys Met  Leu Asp Leu Leu Glu  Asp Phe Leu 
    1070                 1075                 1080             


Glu His  Glu Gly Tyr Lys Tyr  Glu Arg Ile Asp Gly  Gly Ile Xaa 
    1085                 1090                 1095             


Gly Asn  Met Arg Gln Glu Ala  Ile Asp Arg Phe Asn  Ala Pro Gly 
    1100                 1105                 1110             


Ala Gln  Gln Phe Cys Phe Leu  Leu Ser Xaa Arg Ala  Gly Gly Leu 
    1115                 1120                 1125             


Gly Ile  Asn Leu Ala Xaa Ala  Asp Xaa Val Ile Ile  Tyr Asp Ser 
    1130                 1135                 1140             


Asp Trp  Asn Pro His Asn Asp  Ile Gln Ala Phe Ser  Arg Ala His 
    1145                 1150                 1155             


Arg Ile  Gly Gln Asn Lys Lys  Val Met Ile Tyr Arg  Phe Val Xaa 
    1160                 1165                 1170             


Arg Ala  Ser Val Glu Glu Arg  Ile Xaa Gln Val Ala  Lys Lys Lys 
    1175                 1180                 1185             


Met Met  Leu Xaa His Leu Val  Val Arg Pro Gly Leu  Gly Ser Lys 
    1190                 1195                 1200             


Xaa Gly  Ser Met Ser Lys Gln  Glu Leu Asp Asp Ile  Leu Lys Phe 
    1205                 1210                 1215             


Gly Xaa  Glu Glu Leu Phe Lys  Asp Glu Ala Xaa Asp  Gly Gly Gly 
    1220                 1225                 1230             


Asp Asn  Lys Glu Gly Glu Asp  Ser Ser Val Ile His  Tyr Asp Asp 
    1235                 1240                 1245             


Lys Ala  Ile Glu Arg Leu Leu  Asp Arg Asn Gln Asp  Glu Xaa Glu 
    1250                 1255                 1260             


Asp Xaa  Glu Leu Gln Gly Met  Asn Glu Tyr Leu Ser  Ser Phe Lys 
    1265                 1270                 1275             


Val Ala  Gln Tyr Val Val Arg  Glu Glu Glu Met Gly  Glu Glu Glu 
    1280                 1285                 1290             


Glu Val  Glu Arg Glu Ile Ile  Lys Gln Glu Glu Ser  Val Asp Pro 
    1295                 1300                 1305             


Asp Tyr  Trp Glu Lys Leu Leu  Arg His His Tyr Glu  Gln Gln Gln 
    1310                 1315                 1320             


Glu Asp  Leu Ala Arg Asn Leu  Gly Lys Gly Lys Arg  Ile Arg Lys 
    1325                 1330                 1335             


Gln Val  Asn Tyr Asn Asp Gly  Ser Gln Glu Asp Arg  Gly Val Cys 
    1340                 1345                 1350             


Gly Arg  Pro Arg Pro Pro Pro  Met Gly Arg Ser Xaa  Arg Ala Val 
    1355                 1360                 1365             


Gly Pro  Ala His Leu Pro Ser  Leu Pro Pro Asp Trp  Gln Asp Asp 
    1370                 1375                 1380             


Gln Ser  Asp Asn Gln Ser Asp  Tyr Ser Val Ala Ser  Glu Glu Gly 
    1385                 1390                 1395             


Asp Glu  Asp Phe Asp Glu Arg  Ser Glu Ala Pro Arg  Arg Pro Ser 
    1400                 1405                 1410             


Arg Lys  Gly Leu Arg Asn Asp  Lys Asp Lys Pro Leu  Pro Pro Leu 
    1415                 1420                 1425             


Leu Ala  Arg Val Gly Gly Asn  Ile Glu Val Leu Gly  Phe Asn Ala 
    1430                 1435                 1440             


Arg Gln  Arg Lys Ala Phe Leu  Asn Ala Ile Met Arg  Tyr Gly Met 
    1445                 1450                 1455             


Pro Pro  Gln Asp Ala Phe Xaa  Xaa Gln Trp Leu Val  Arg Asp Leu 
    1460                 1465                 1470             


Arg Gly  Lys Ser Glu Lys Glu  Phe Lys Ala Tyr Val  Ser Leu Phe 
    1475                 1480                 1485             


Met Arg  His Leu Cys Glu Pro  Gly Ala Asp Gly Ala  Glu Xaa Phe 
    1490                 1495                 1500             


Ala Asp  Gly Val Pro Arg Glu  Gly Leu Ser Arg Gln  His Val Leu 
    1505                 1510                 1515             


Xaa Arg  Ile Gly Val Met Ser  Leu Ile Arg Lys Lys  Val Gln Glu 
    1520                 1525                 1530             


Phe Glu  His Val Asn Gly Arg  Trp Ser Met Pro Glu  Leu Ala Glu 
    1535                 1540                 1545             


Val Glu  Glu Asn Lys Lys Met  Ser Gln Pro Gly Ser  Pro Ser Pro 
    1550                 1555                 1560             


Lys Xaa  Pro Xaa Pro Ser Xaa  Pro Gly Asp Xaa Gln  Pro Asn Xaa 
    1565                 1570                 1575             


Pro Ala  Pro Val Pro Pro Ala  Glu Asp Gly Ile Lys  Ile Glu Glu 
    1580                 1585                 1590             


Asn Ser  Leu Lys Glu Glu Glu  Ser Ile Glu Gly Glu  Lys Glu Val 
    1595                 1600                 1605             


Lys Ser  Xaa Ala Pro Glu Xaa  Ala Ile Glu Cys Xaa  Gln Ala Pro 
    1610                 1615                 1620             


Ala Pro  Ala Ser Glu Asp Glu  Lys Val Val Val Glu  Pro Pro Glu 
    1625                 1630                 1635             


Gly Glu  Glu Lys Val Glu Lys  Ala Glu Val Lys Glu  Arg Xaa Glu 
    1640                 1645                 1650             


Glu Pro  Met Glu Xaa Glu Pro  Lys Gly Ala Ala Asp  Val Glu Lys 
    1655                 1660                 1665             


Val Glu  Glu Lys Ser Ala Ile  Asp Leu Xaa Pro Ile  Val Val Glu 
    1670                 1675                 1680             


Asp Lys  Glu Glu Lys Lys Glu  Glu Glu Glu Lys Lys  Glu Val Met 
    1685                 1690                 1695             


Leu Gln  Asn Gly Glu Xaa Pro  Lys Asp Leu Asn Asp  Glu Lys Gln 
    1700                 1705                 1710             


Lys Lys  Asn Ile Lys Gln Arg  Phe Met Phe Asn Ile  Ala Asp Gly 
    1715                 1720                 1725             


Gly Phe  Xaa Glu Leu His Ser  Leu Trp Gln Asn Glu  Glu Arg Ala 
    1730                 1735                 1740             


Ala Xaa  Val Xaa Lys Lys Xaa  Tyr Glu Ile Trp His  Arg Arg His 
    1745                 1750                 1755             


Asp Tyr  Trp Leu Leu Ala Gly  Ile Ile Asn His Gly  Tyr Ala Arg 
    1760                 1765                 1770             


Trp Gln  Asp Ile Gln Asn Asp  Pro Arg Tyr Ala Ile  Leu Asn Glu 
    1775                 1780                 1785             


Pro Phe  Lys Gly Glu Met Asn  Arg Gly Asn Phe Leu  Glu Ile Lys 
    1790                 1795                 1800             


Asn Lys  Phe Leu Ala Arg Arg  Phe Lys Leu Leu Glu  Gln Ala Leu 
    1805                 1810                 1815             


Val Ile  Glu Glu Gln Leu Arg  Arg Ala Ala Tyr Leu  Asn Met Ser 
    1820                 1825                 1830             


Glu Asp  Pro Ser His Pro Ser  Met Ala Leu Asn Xaa  Arg Phe Ala 
    1835                 1840                 1845             


Glu Val  Glu Cys Leu Ala Glu  Ser His Gln His Leu  Ser Lys Glu 
    1850                 1855                 1860             


Ser Met  Ala Gly Asn Lys Pro  Ala Asn Ala Val Leu  His Lys Val 
    1865                 1870                 1875             


Leu Lys  Gln Leu Glu Glu Leu  Leu Ser Asp Met Lys  Ala Asp Val 
    1880                 1885                 1890             


Xaa Arg  Leu Pro Ala Xaa Ile  Ala Arg Ile Pro Pro  Val Ala Val 
    1895                 1900                 1905             


Arg Leu  Gln Met Ser Glu Arg  Asn Ile Leu Ser Arg  Leu Ala Asn 
    1910                 1915                 1920             


Arg Ala  Pro Glu Pro Xaa Pro  Gln Gln Val Ala Gln  Gln Gln 
    1925                 1930                 1935         


<210> 5992
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<400> 5992
Met Ala Ser Gly Leu Gly Ser Pro Ser Pro Cys Ser Ala Gly Ser Glu 
1               5                   10                  15      


Glu Glu Asp Met Asp Ala Leu Leu Asn Asn Ser Leu Pro Pro Pro His 
            20                  25                  30          


Pro Glu Asn Glu Glu Asp Pro Glu Glu Asp Leu Ser Glu Xaa Glu Xaa 
        35                  40                  45              


Pro Lys Leu Lys Lys Lys Lys Lys Pro Lys Lys Pro Arg Asp Pro Lys 
    50                  55                  60                  


Ile Pro Lys Ser Lys Arg Gln Lys Lys Glu Leu Gly Asp Ser Ser Gly 
65                  70                  75                  80  


Glu Gly Pro Glu Phe Val Glu Glu Glu Glu Glu Val Ala Leu Arg Ser 
                85                  90                  95      


Asp Ser Glu Gly Ser Asp Tyr Xaa Pro Gly Lys Lys Lys Lys Lys Lys 
            100                 105                 110         


Leu Gly Pro Lys Lys Glu Lys Lys Ser Lys Ser Lys Arg 
        115                 120                 125 


<210> 5993
<211> 1905
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (984)..(984)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1200)..(1200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1261)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1433)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1470)..(1470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1487)..(1487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1533)..(1533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1535)..(1535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1538)..(1538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1546)..(1546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1579)..(1579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1583)..(1583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1588)..(1588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1620)..(1620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1626)..(1626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1672)..(1672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1699)..(1699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1713)..(1713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1715)..(1715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1718)..(1718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1813)..(1813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1862)..(1862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1867)..(1867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1897)..(1897)
<223> Selenocysteine

<400> 5993
Met Ala Ser Gly Leu Gly Ser Pro Ser Pro Cys Ser Ala Gly Ser Glu 
1               5                   10                  15      


Glu Glu Asp Met Asp Ala Leu Leu Asn Asn Ser Leu Pro Pro Pro His 
            20                  25                  30          


Pro Glu Asn Glu Glu Asp Pro Glu Glu Asp Leu Ser Glu Xaa Glu Xaa 
        35                  40                  45              


Pro Lys Leu Lys Lys Lys Lys Lys Pro Lys Lys Pro Arg Asp Pro Lys 
    50                  55                  60                  


Ile Pro Lys Ser Lys Arg Gln Lys Lys Glu Leu Gly Asp Ser Ser Gly 
65                  70                  75                  80  


Glu Gly Pro Glu Phe Val Glu Glu Glu Glu Glu Val Ala Leu Arg Ser 
                85                  90                  95      


Asp Ser Glu Gly Ser Asp Tyr Xaa Pro Gly Lys Lys Lys Lys Lys Lys 
            100                 105                 110         


Leu Gly Pro Lys Lys Glu Lys Lys Ser Lys Ser Lys Arg Lys Glu Glu 
        115                 120                 125             


Glu Glu Glu Glu Asp Asp Asp Asp Asp Ser Lys Glu Pro Lys Ser Ser 
    130                 135                 140                 


Ala Gln Leu Leu Glu Asp Trp Gly Met Glu Asp Ile Asp His Val Phe 
145                 150                 155                 160 


Ser Glu Glu Asp Tyr Arg Xaa Leu Xaa Asn Tyr Lys Ala Phe Ser Gln 
                165                 170                 175     


Phe Val Arg Pro Leu Ile Ala Ala Lys Asn Pro Lys Ile Ala Val Ser 
            180                 185                 190         


Lys Met Met Met Val Leu Gly Ala Lys Trp Arg Glu Phe Ser Xaa Asn 
        195                 200                 205             


Asn Pro Phe Lys Gly Ser Ser Gly Ala Ser Val Ala Ala Ala Ala Ala 
    210                 215                 220                 


Ala Ala Val Ala Val Val Glu Ser Met Val Xaa Ala Xaa Glu Val Ala 
225                 230                 235                 240 


Pro Pro Pro Pro Pro Val Glu Val Pro Ile Arg Lys Ala Lys Xaa Lys 
                245                 250                 255     


Glu Gly Lys Gly Pro Asn Ala Arg Arg Lys Pro Lys Gly Ser Pro Arg 
            260                 265                 270         


Val Pro Asp Ala Lys Lys Pro Lys Pro Lys Lys Val Ala Pro Leu Lys 
        275                 280                 285             


Ile Lys Leu Gly Gly Phe Gly Ser Lys Arg Lys Arg Ser Ser Ser Glu 
    290                 295                 300                 


Asp Asp Asp Leu Asp Val Glu Ser Asp Phe Asp Asp Ala Ser Ile Asn 
305                 310                 315                 320 


Ser Tyr Ser Val Ser Asp Gly Ser Xaa Ser Arg Ser Ser Arg Ser Arg 
                325                 330                 335     


Lys Lys Leu Arg Xaa Xaa Lys Lys Lys Lys Lys Gly Glu Glu Glu Val 
            340                 345                 350         


Xaa Ala Val Asp Gly Tyr Glu Xaa Asp His Gln Asp Tyr Cys Glu Val 
        355                 360                 365             


Cys Gln Gln Gly Gly Glu Ile Ile Leu Cys Asp Xaa Cys Pro Arg Ala 
    370                 375                 380                 


Tyr His Met Val Cys Leu Asp Pro Asp Met Glu Lys Ala Pro Glu Gly 
385                 390                 395                 400 


Lys Trp Ser Cys Pro His Cys Glu Lys Glu Gly Ile Gln Trp Glu Ala 
                405                 410                 415     


Lys Glu Asp Asn Ser Glu Gly Glu Glu Ile Leu Glu Glu Val Gly Gly 
            420                 425                 430         


Asp Leu Glu Glu Glu Asp Asp His His Met Glu Phe Cys Arg Val Cys 
        435                 440                 445             


Lys Asp Gly Gly Glu Leu Leu Cys Cys Asp Xaa Cys Pro Ser Ser Tyr 
    450                 455                 460                 


His Ile His Cys Leu Asn Pro Pro Leu Pro Glu Ile Pro Asn Gly Glu 
465                 470                 475                 480 


Trp Leu Cys Pro Arg Cys Xaa Cys Pro Ala Leu Lys Gly Lys Val Gln 
                485                 490                 495     


Lys Ile Leu Ile Trp Lys Trp Gly Gln Pro Pro Ser Pro Xaa Pro Val 
            500                 505                 510         


Pro Arg Pro Pro Asp Ala Asp Pro Asn Xaa Pro Ser Pro Lys Pro Leu 
        515                 520                 525             


Glu Gly Arg Pro Glu Arg Gln Phe Phe Val Lys Trp Gln Gly Met Ser 
    530                 535                 540                 


Tyr Trp His Cys Ser Trp Val Ser Glu Leu Gln Leu Glu Leu His Cys 
545                 550                 555                 560 


Gln Val Met Phe Arg Asn Tyr Gln Arg Lys Asn Asp Met Asp Glu Pro 
                565                 570                 575     


Pro Ser Gly Asp Phe Gly Gly Asp Glu Glu Lys Ser Arg Lys Arg Lys 
            580                 585                 590         


Asn Lys Asp Pro Lys Phe Ala Glu Met Glu Glu Arg Phe Tyr Arg Tyr 
        595                 600                 605             


Gly Ile Lys Pro Glu Trp Met Met Ile His Arg Ile Leu Asn His Ser 
    610                 615                 620                 


Val Asp Lys Lys Gly His Val His Tyr Leu Ile Lys Trp Arg Asp Leu 
625                 630                 635                 640 


Pro Tyr Asp Gln Ala Ser Trp Glu Ser Glu Asp Val Glu Ile Gln Asp 
                645                 650                 655     


Tyr Asp Leu Phe Lys Gln Ser Tyr Trp Asn His Arg Glu Leu Met Arg 
            660                 665                 670         


Gly Glu Glu Gly Arg Pro Gly Lys Lys Leu Lys Lys Val Lys Leu Arg 
        675                 680                 685             


Lys Leu Glu Arg Pro Pro Glu Xaa Pro Xaa Val Asp Pro Xaa Val Lys 
    690                 695                 700                 


Tyr Glu Arg Gln Pro Glu Tyr Leu Asp Ala Xaa Gly Gly Xaa Leu His 
705                 710                 715                 720 


Pro Tyr Gln Met Glu Gly Leu Asn Trp Leu Arg Phe Ser Trp Ala Gln 
                725                 730                 735     


Gly Xaa Asp Xaa Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Xaa Val 
            740                 745                 750         


Gln Xaa Ala Val Phe Leu Tyr Ser Leu Tyr Lys Glu Gly His Ser Lys 
        755                 760                 765             


Gly Pro Phe Leu Val Ser Ala Pro Leu Ser Xaa Ile Ile Asn Trp Glu 
    770                 775                 780                 


Arg Glu Phe Glu Met Trp Ala Pro Asp Met Tyr Val Val Xaa Tyr Val 
785                 790                 795                 800 


Gly Asp Lys Asp Ser Arg Ala Ile Ile Arg Glu Asn Glu Phe Ser Phe 
                805                 810                 815     


Glu Asp Asn Ala Ile Arg Gly Gly Lys Lys Ala Ser Arg Met Lys Lys 
            820                 825                 830         


Glu Ala Ser Val Lys Phe His Val Leu Leu Xaa Ser Tyr Glu Leu Ile 
        835                 840                 845             


Xaa Ile Asp Met Ala Ile Leu Gly Ser Ile Asp Trp Ala Cys Leu Ile 
    850                 855                 860                 


Val Asp Glu Ala His Arg Leu Lys Asn Asn Gln Ser Lys Phe Phe Arg 
865                 870                 875                 880 


Val Leu Asn Gly Tyr Ser Leu Gln His Lys Leu Leu Leu Xaa Gly Xaa 
                885                 890                 895     


Pro Leu Gln Asn Asn Leu Glu Glu Leu Phe His Leu Leu Asn Phe Leu 
            900                 905                 910         


Xaa Pro Glu Arg Phe His Asn Leu Glu Gly Phe Leu Glu Glu Phe Ala 
        915                 920                 925             


Asp Ile Ala Lys Glu Asp Gln Ile Lys Lys Leu His Asp Met Leu Gly 
    930                 935                 940                 


Pro His Met Leu Arg Arg Leu Lys Ala Asp Val Phe Lys Asn Met Pro 
945                 950                 955                 960 


Ser Lys Xaa Glu Leu Ile Val Arg Val Glu Leu Ser Pro Met Gln Lys 
                965                 970                 975     


Lys Tyr Tyr Lys Tyr Ile Leu Xaa Arg Asn Phe Glu Ala Leu Asn Ala 
            980                 985                 990         


Arg Gly Gly Gly Asn Gln Val Ser  Leu Leu Asn Val Val  Met Asp Leu 
        995                 1000                 1005             


Lys Lys  Cys Cys Asn His Pro  Tyr Leu Phe Pro Val  Ala Ala Met 
    1010                 1015                 1020             


Glu Ala  Pro Lys Met Pro Asn  Gly Met Tyr Asp Gly  Ser Ala Leu 
    1025                 1030                 1035             


Ile Arg  Ala Ser Gly Lys Leu  Leu Leu Leu Gln Lys  Met Leu Lys 
    1040                 1045                 1050             


Asn Leu  Lys Glu Gly Gly His  Arg Val Leu Ile Phe  Ser Gln Met 
    1055                 1060                 1065             


Xaa Lys  Met Leu Asp Leu Leu  Glu Asp Phe Leu Glu  His Glu Gly 
    1070                 1075                 1080             


Tyr Lys  Tyr Glu Arg Ile Asp  Gly Gly Ile Xaa Gly  Asn Met Arg 
    1085                 1090                 1095             


Gln Glu  Ala Ile Asp Arg Phe  Asn Ala Pro Gly Ala  Gln Gln Phe 
    1100                 1105                 1110             


Cys Phe  Leu Leu Ser Xaa Arg  Ala Gly Gly Leu Gly  Ile Asn Leu 
    1115                 1120                 1125             


Ala Xaa  Ala Asp Xaa Val Ile  Ile Tyr Asp Ser Asp  Trp Asn Pro 
    1130                 1135                 1140             


His Asn  Asp Ile Gln Ala Phe  Ser Arg Ala His Arg  Ile Gly Gln 
    1145                 1150                 1155             


Asn Lys  Lys Val Met Ile Tyr  Arg Phe Val Xaa Arg  Ala Ser Val 
    1160                 1165                 1170             


Glu Glu  Arg Ile Xaa Gln Val  Ala Lys Lys Lys Met  Met Leu Xaa 
    1175                 1180                 1185             


His Leu  Val Val Arg Pro Gly  Leu Gly Ser Lys Xaa  Gly Ser Met 
    1190                 1195                 1200             


Ser Lys  Gln Glu Leu Asp Asp  Ile Leu Lys Phe Gly  Xaa Glu Glu 
    1205                 1210                 1215             


Leu Phe  Lys Asp Glu Ala Xaa  Asp Gly Gly Gly Asp  Asn Lys Glu 
    1220                 1225                 1230             


Gly Glu  Asp Ser Ser Val Ile  His Tyr Asp Asp Lys  Ala Ile Glu 
    1235                 1240                 1245             


Arg Leu  Leu Asp Arg Asn Gln  Asp Glu Xaa Glu Asp  Xaa Glu Leu 
    1250                 1255                 1260             


Gln Gly  Met Asn Glu Tyr Leu  Ser Ser Phe Lys Val  Ala Gln Tyr 
    1265                 1270                 1275             


Val Val  Arg Glu Glu Glu Met  Gly Glu Glu Glu Glu  Val Glu Arg 
    1280                 1285                 1290             


Glu Ile  Ile Lys Gln Glu Glu  Ser Val Asp Pro Asp  Tyr Trp Glu 
    1295                 1300                 1305             


Lys Leu  Leu Arg His His Tyr  Glu Gln Gln Gln Glu  Asp Leu Ala 
    1310                 1315                 1320             


Arg Asn  Leu Gly Lys Gly Lys  Arg Ile Arg Lys Gln  Val Asn Tyr 
    1325                 1330                 1335             


Asn Asp  Gly Ser Gln Glu Asp  Arg Asp Trp Gln Asp  Asp Gln Ser 
    1340                 1345                 1350             


Asp Asn  Gln Ser Asp Tyr Ser  Val Ala Ser Glu Glu  Gly Asp Glu 
    1355                 1360                 1365             


Asp Phe  Asp Glu Arg Ser Glu  Ala Pro Arg Arg Pro  Ser Arg Lys 
    1370                 1375                 1380             


Gly Leu  Arg Asn Asp Lys Asp  Lys Pro Leu Pro Pro  Leu Leu Ala 
    1385                 1390                 1395             


Arg Val  Gly Gly Asn Ile Glu  Val Leu Gly Phe Asn  Ala Arg Gln 
    1400                 1405                 1410             


Arg Lys  Ala Phe Leu Asn Ala  Ile Met Arg Tyr Gly  Met Pro Pro 
    1415                 1420                 1425             


Gln Asp  Ala Phe Xaa Xaa Gln  Trp Leu Val Arg Asp  Leu Arg Gly 
    1430                 1435                 1440             


Lys Ser  Glu Lys Glu Phe Lys  Ala Tyr Val Ser Leu  Phe Met Arg 
    1445                 1450                 1455             


His Leu  Cys Glu Pro Gly Ala  Asp Gly Ala Glu Xaa  Phe Ala Asp 
    1460                 1465                 1470             


Gly Val  Pro Arg Glu Gly Leu  Ser Arg Gln His Val  Leu Xaa Arg 
    1475                 1480                 1485             


Ile Gly  Val Met Ser Leu Ile  Arg Lys Lys Val Gln  Glu Phe Glu 
    1490                 1495                 1500             


His Val  Asn Gly Arg Trp Ser  Met Pro Glu Leu Ala  Glu Val Glu 
    1505                 1510                 1515             


Glu Asn  Lys Lys Met Ser Gln  Pro Gly Ser Pro Ser  Pro Lys Xaa 
    1520                 1525                 1530             


Pro Xaa  Pro Ser Xaa Pro Gly  Asp Xaa Gln Pro Asn  Xaa Pro Ala 
    1535                 1540                 1545             


Pro Val  Pro Pro Ala Glu Asp  Gly Ile Lys Ile Glu  Glu Asn Ser 
    1550                 1555                 1560             


Leu Lys  Glu Glu Glu Ser Ile  Glu Gly Glu Lys Glu  Val Lys Ser 
    1565                 1570                 1575             


Xaa Ala  Pro Glu Xaa Ala Ile  Glu Cys Xaa Gln Ala  Pro Ala Pro 
    1580                 1585                 1590             


Ala Ser  Glu Asp Glu Lys Val  Val Val Glu Pro Pro  Glu Gly Glu 
    1595                 1600                 1605             


Glu Lys  Val Glu Lys Ala Glu  Val Lys Glu Arg Xaa  Glu Glu Pro 
    1610                 1615                 1620             


Met Glu  Xaa Glu Pro Lys Gly  Ala Ala Asp Val Glu  Lys Val Glu 
    1625                 1630                 1635             


Glu Lys  Ser Ala Ile Asp Leu  Xaa Pro Ile Val Val  Glu Asp Lys 
    1640                 1645                 1650             


Glu Glu  Lys Lys Glu Glu Glu  Glu Lys Lys Glu Val  Met Leu Gln 
    1655                 1660                 1665             


Asn Gly  Glu Xaa Pro Lys Asp  Leu Asn Asp Glu Lys  Gln Lys Lys 
    1670                 1675                 1680             


Asn Ile  Lys Gln Arg Phe Met  Phe Asn Ile Ala Asp  Gly Gly Phe 
    1685                 1690                 1695             


Xaa Glu  Leu His Ser Leu Trp  Gln Asn Glu Glu Arg  Ala Ala Xaa 
    1700                 1705                 1710             


Val Xaa  Lys Lys Xaa Tyr Glu  Ile Trp His Arg Arg  His Asp Tyr 
    1715                 1720                 1725             


Trp Leu  Leu Ala Gly Ile Ile  Asn His Gly Tyr Ala  Arg Trp Gln 
    1730                 1735                 1740             


Asp Ile  Gln Asn Asp Pro Arg  Tyr Ala Ile Leu Asn  Glu Pro Phe 
    1745                 1750                 1755             


Lys Gly  Glu Met Asn Arg Gly  Asn Phe Leu Glu Ile  Lys Asn Lys 
    1760                 1765                 1770             


Phe Leu  Ala Arg Arg Phe Lys  Leu Leu Glu Gln Ala  Leu Val Ile 
    1775                 1780                 1785             


Glu Glu  Gln Leu Arg Arg Ala  Ala Tyr Leu Asn Met  Ser Glu Asp 
    1790                 1795                 1800             


Pro Ser  His Pro Ser Met Ala  Leu Asn Xaa Arg Phe  Ala Glu Val 
    1805                 1810                 1815             


Glu Cys  Leu Ala Glu Ser His  Gln His Leu Ser Lys  Glu Ser Met 
    1820                 1825                 1830             


Ala Gly  Asn Lys Pro Ala Asn  Ala Val Leu His Lys  Val Leu Lys 
    1835                 1840                 1845             


Gln Leu  Glu Glu Leu Leu Ser  Asp Met Lys Ala Asp  Val Xaa Arg 
    1850                 1855                 1860             


Leu Pro  Ala Xaa Ile Ala Arg  Ile Pro Pro Val Ala  Val Arg Leu 
    1865                 1870                 1875             


Gln Met  Ser Glu Arg Asn Ile  Leu Ser Arg Leu Ala  Asn Arg Ala 
    1880                 1885                 1890             


Pro Glu  Pro Xaa Pro Gln Gln  Val Ala Gln Gln Gln  
    1895                 1900                 1905 


<210> 5994
<211> 354
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(349)
<223> Selenocysteine

<400> 5994
Met Ala Ser Gly Leu Gly Ser Pro Ser Pro Cys Ser Ala Gly Ser Glu 
1               5                   10                  15      


Glu Glu Asp Met Asp Ala Leu Leu Asn Asn Ser Leu Pro Pro Pro His 
            20                  25                  30          


Pro Glu Asn Glu Glu Asp Pro Glu Glu Asp Leu Ser Glu Xaa Glu Xaa 
        35                  40                  45              


Pro Lys Leu Lys Lys Lys Lys Lys Pro Lys Lys Pro Arg Asp Pro Lys 
    50                  55                  60                  


Ile Pro Lys Ser Lys Arg Gln Lys Lys Glu Arg Met Leu Leu Cys Arg 
65                  70                  75                  80  


Gln Leu Gly Asp Ser Ser Gly Glu Gly Pro Glu Phe Val Glu Glu Glu 
                85                  90                  95      


Glu Glu Val Ala Leu Arg Ser Asp Ser Glu Gly Ser Asp Tyr Xaa Pro 
            100                 105                 110         


Gly Lys Lys Lys Lys Lys Lys Leu Gly Pro Lys Lys Glu Lys Lys Ser 
        115                 120                 125             


Lys Ser Lys Arg Lys Glu Glu Glu Glu Glu Glu Asp Asp Asp Asp Asp 
    130                 135                 140                 


Ser Lys Glu Pro Lys Ser Ser Ala Gln Leu Leu Glu Asp Trp Gly Met 
145                 150                 155                 160 


Glu Asp Ile Asp His Val Phe Ser Glu Glu Asp Tyr Arg Xaa Leu Xaa 
                165                 170                 175     


Asn Tyr Lys Ala Phe Ser Gln Phe Val Arg Pro Leu Ile Ala Ala Lys 
            180                 185                 190         


Asn Pro Lys Ile Ala Val Ser Lys Met Met Met Val Leu Gly Ala Lys 
        195                 200                 205             


Trp Arg Glu Phe Ser Xaa Asn Asn Pro Phe Lys Gly Ser Ser Gly Ala 
    210                 215                 220                 


Ser Val Ala Ala Ala Ala Ala Ala Ala Val Ala Val Val Glu Ser Met 
225                 230                 235                 240 


Val Xaa Ala Xaa Glu Val Ala Pro Pro Pro Pro Pro Val Glu Val Pro 
                245                 250                 255     


Ile Arg Lys Ala Lys Xaa Lys Glu Gly Lys Gly Pro Asn Ala Arg Arg 
            260                 265                 270         


Lys Pro Lys Gly Ser Pro Arg Val Pro Asp Ala Lys Lys Pro Lys Pro 
        275                 280                 285             


Lys Lys Val Ala Pro Leu Lys Ile Lys Leu Gly Gly Phe Gly Ser Lys 
    290                 295                 300                 


Arg Lys Arg Ser Ser Ser Glu Asp Asp Asp Leu Asp Val Glu Ser Asp 
305                 310                 315                 320 


Phe Asp Asp Ala Ser Ile Asn Ser Tyr Ser Val Ser Asp Gly Ser Xaa 
                325                 330                 335     


Ser Arg Ser Ser Arg Ser Arg Lys Lys Leu Arg Xaa Xaa Lys Lys Lys 
            340                 345                 350         


Lys Lys 
        


<210> 5995
<211> 1912
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1176)..(1176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1195)..(1195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1268)..(1268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1440)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1477)..(1477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1494)..(1494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1540)..(1540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1549)..(1549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1553)..(1553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1590)..(1590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1595)..(1595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1627)..(1627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1653)..(1653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1679)..(1679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1706)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1720)..(1720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1722)..(1722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1725)..(1725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1820)..(1820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1869)..(1869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1874)..(1874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1904)..(1904)
<223> Selenocysteine

<400> 5995
Met Ala Ser Gly Leu Gly Ser Pro Ser Pro Cys Ser Ala Gly Ser Glu 
1               5                   10                  15      


Glu Glu Asp Met Asp Ala Leu Leu Asn Asn Ser Leu Pro Pro Pro His 
            20                  25                  30          


Pro Glu Asn Glu Glu Asp Pro Glu Glu Asp Leu Ser Glu Xaa Glu Xaa 
        35                  40                  45              


Pro Lys Leu Lys Lys Lys Lys Lys Pro Lys Lys Pro Arg Asp Pro Lys 
    50                  55                  60                  


Ile Pro Lys Ser Lys Arg Gln Lys Lys Glu Arg Met Leu Leu Cys Arg 
65                  70                  75                  80  


Gln Leu Gly Asp Ser Ser Gly Glu Gly Pro Glu Phe Val Glu Glu Glu 
                85                  90                  95      


Glu Glu Val Ala Leu Arg Ser Asp Ser Glu Gly Ser Asp Tyr Xaa Pro 
            100                 105                 110         


Gly Lys Lys Lys Lys Lys Lys Leu Gly Pro Lys Lys Glu Lys Lys Ser 
        115                 120                 125             


Lys Ser Lys Arg Lys Glu Glu Glu Glu Glu Glu Asp Asp Asp Asp Asp 
    130                 135                 140                 


Ser Lys Glu Pro Lys Ser Ser Ala Gln Leu Leu Glu Asp Trp Gly Met 
145                 150                 155                 160 


Glu Asp Ile Asp His Val Phe Ser Glu Glu Asp Tyr Arg Xaa Leu Xaa 
                165                 170                 175     


Asn Tyr Lys Ala Phe Ser Gln Phe Val Arg Pro Leu Ile Ala Ala Lys 
            180                 185                 190         


Asn Pro Lys Ile Ala Val Ser Lys Met Met Met Val Leu Gly Ala Lys 
        195                 200                 205             


Trp Arg Glu Phe Ser Xaa Asn Asn Pro Phe Lys Gly Ser Ser Gly Ala 
    210                 215                 220                 


Ser Val Ala Ala Ala Ala Ala Ala Ala Val Ala Val Val Glu Ser Met 
225                 230                 235                 240 


Val Xaa Ala Xaa Glu Val Ala Pro Pro Pro Pro Pro Val Glu Val Pro 
                245                 250                 255     


Ile Arg Lys Ala Lys Xaa Lys Glu Gly Lys Gly Pro Asn Ala Arg Arg 
            260                 265                 270         


Lys Pro Lys Gly Ser Pro Arg Val Pro Asp Ala Lys Lys Pro Lys Pro 
        275                 280                 285             


Lys Lys Val Ala Pro Leu Lys Ile Lys Leu Gly Gly Phe Gly Ser Lys 
    290                 295                 300                 


Arg Lys Arg Ser Ser Ser Glu Asp Asp Asp Leu Asp Val Glu Ser Asp 
305                 310                 315                 320 


Phe Asp Asp Ala Ser Ile Asn Ser Tyr Ser Val Ser Asp Gly Ser Xaa 
                325                 330                 335     


Ser Arg Ser Ser Arg Ser Arg Lys Lys Leu Arg Xaa Xaa Lys Lys Lys 
            340                 345                 350         


Lys Lys Gly Glu Glu Glu Val Xaa Ala Val Asp Gly Tyr Glu Xaa Asp 
        355                 360                 365             


His Gln Asp Tyr Cys Glu Val Cys Gln Gln Gly Gly Glu Ile Ile Leu 
    370                 375                 380                 


Cys Asp Xaa Cys Pro Arg Ala Tyr His Met Val Cys Leu Asp Pro Asp 
385                 390                 395                 400 


Met Glu Lys Ala Pro Glu Gly Lys Trp Ser Cys Pro His Cys Glu Lys 
                405                 410                 415     


Glu Gly Ile Gln Trp Glu Ala Lys Glu Asp Asn Ser Glu Gly Glu Glu 
            420                 425                 430         


Ile Leu Glu Glu Val Gly Gly Asp Leu Glu Glu Glu Asp Asp His His 
        435                 440                 445             


Met Glu Phe Cys Arg Val Cys Lys Asp Gly Gly Glu Leu Leu Cys Cys 
    450                 455                 460                 


Asp Xaa Cys Pro Ser Ser Tyr His Ile His Cys Leu Asn Pro Pro Leu 
465                 470                 475                 480 


Pro Glu Ile Pro Asn Gly Glu Trp Leu Cys Pro Arg Cys Xaa Cys Pro 
                485                 490                 495     


Ala Leu Lys Gly Lys Val Gln Lys Ile Leu Ile Trp Lys Trp Gly Gln 
            500                 505                 510         


Pro Pro Ser Pro Xaa Pro Val Pro Arg Pro Pro Asp Ala Asp Pro Asn 
        515                 520                 525             


Xaa Pro Ser Pro Lys Pro Leu Glu Gly Arg Pro Glu Arg Gln Phe Phe 
    530                 535                 540                 


Val Lys Trp Gln Gly Met Ser Tyr Trp His Cys Ser Trp Val Ser Glu 
545                 550                 555                 560 


Leu Gln Leu Glu Leu His Cys Gln Val Met Phe Arg Asn Tyr Gln Arg 
                565                 570                 575     


Lys Asn Asp Met Asp Glu Pro Pro Ser Gly Asp Phe Gly Gly Asp Glu 
            580                 585                 590         


Glu Lys Ser Arg Lys Arg Lys Asn Lys Asp Pro Lys Phe Ala Glu Met 
        595                 600                 605             


Glu Glu Arg Phe Tyr Arg Tyr Gly Ile Lys Pro Glu Trp Met Met Ile 
    610                 615                 620                 


His Arg Ile Leu Asn His Ser Val Asp Lys Lys Gly His Val His Tyr 
625                 630                 635                 640 


Leu Ile Lys Trp Arg Asp Leu Pro Tyr Asp Gln Ala Ser Trp Glu Ser 
                645                 650                 655     


Glu Asp Val Glu Ile Gln Asp Tyr Asp Leu Phe Lys Gln Ser Tyr Trp 
            660                 665                 670         


Asn His Arg Glu Leu Met Arg Gly Glu Glu Gly Arg Pro Gly Lys Lys 
        675                 680                 685             


Leu Lys Lys Val Lys Leu Arg Lys Leu Glu Arg Pro Pro Glu Xaa Pro 
    690                 695                 700                 


Xaa Val Asp Pro Xaa Val Lys Tyr Glu Arg Gln Pro Glu Tyr Leu Asp 
705                 710                 715                 720 


Ala Xaa Gly Gly Xaa Leu His Pro Tyr Gln Met Glu Gly Leu Asn Trp 
                725                 730                 735     


Leu Arg Phe Ser Trp Ala Gln Gly Xaa Asp Xaa Ile Leu Ala Asp Glu 
            740                 745                 750         


Met Gly Leu Gly Lys Xaa Val Gln Xaa Ala Val Phe Leu Tyr Ser Leu 
        755                 760                 765             


Tyr Lys Glu Gly His Ser Lys Gly Pro Phe Leu Val Ser Ala Pro Leu 
    770                 775                 780                 


Ser Xaa Ile Ile Asn Trp Glu Arg Glu Phe Glu Met Trp Ala Pro Asp 
785                 790                 795                 800 


Met Tyr Val Val Xaa Tyr Val Gly Asp Lys Asp Ser Arg Ala Ile Ile 
                805                 810                 815     


Arg Glu Asn Glu Phe Ser Phe Glu Asp Asn Ala Ile Arg Gly Gly Lys 
            820                 825                 830         


Lys Ala Ser Arg Met Lys Lys Glu Ala Ser Val Lys Phe His Val Leu 
        835                 840                 845             


Leu Xaa Ser Tyr Glu Leu Ile Xaa Ile Asp Met Ala Ile Leu Gly Ser 
    850                 855                 860                 


Ile Asp Trp Ala Cys Leu Ile Val Asp Glu Ala His Arg Leu Lys Asn 
865                 870                 875                 880 


Asn Gln Ser Lys Phe Phe Arg Val Leu Asn Gly Tyr Ser Leu Gln His 
                885                 890                 895     


Lys Leu Leu Leu Xaa Gly Xaa Pro Leu Gln Asn Asn Leu Glu Glu Leu 
            900                 905                 910         


Phe His Leu Leu Asn Phe Leu Xaa Pro Glu Arg Phe His Asn Leu Glu 
        915                 920                 925             


Gly Phe Leu Glu Glu Phe Ala Asp Ile Ala Lys Glu Asp Gln Ile Lys 
    930                 935                 940                 


Lys Leu His Asp Met Leu Gly Pro His Met Leu Arg Arg Leu Lys Ala 
945                 950                 955                 960 


Asp Val Phe Lys Asn Met Pro Ser Lys Xaa Glu Leu Ile Val Arg Val 
                965                 970                 975     


Glu Leu Ser Pro Met Gln Lys Lys Tyr Tyr Lys Tyr Ile Leu Xaa Arg 
            980                 985                 990         


Asn Phe Glu Ala Leu Asn Ala Arg  Gly Gly Gly Asn Gln  Val Ser Leu 
        995                 1000                 1005             


Leu Asn  Val Val Met Asp Leu  Lys Lys Cys Cys Asn  His Pro Tyr 
    1010                 1015                 1020             


Leu Phe  Pro Val Ala Ala Met  Glu Ala Pro Lys Met  Pro Asn Gly 
    1025                 1030                 1035             


Met Tyr  Asp Gly Ser Ala Leu  Ile Arg Ala Ser Gly  Lys Leu Leu 
    1040                 1045                 1050             


Leu Leu  Gln Lys Met Leu Lys  Asn Leu Lys Glu Gly  Gly His Arg 
    1055                 1060                 1065             


Val Leu  Ile Phe Ser Gln Met  Xaa Lys Met Leu Asp  Leu Leu Glu 
    1070                 1075                 1080             


Asp Phe  Leu Glu His Glu Gly  Tyr Lys Tyr Glu Arg  Ile Asp Gly 
    1085                 1090                 1095             


Gly Ile  Xaa Gly Asn Met Arg  Gln Glu Ala Ile Asp  Arg Phe Asn 
    1100                 1105                 1110             


Ala Pro  Gly Ala Gln Gln Phe  Cys Phe Leu Leu Ser  Xaa Arg Ala 
    1115                 1120                 1125             


Gly Gly  Leu Gly Ile Asn Leu  Ala Xaa Ala Asp Xaa  Val Ile Ile 
    1130                 1135                 1140             


Tyr Asp  Ser Asp Trp Asn Pro  His Asn Asp Ile Gln  Ala Phe Ser 
    1145                 1150                 1155             


Arg Ala  His Arg Ile Gly Gln  Asn Lys Lys Val Met  Ile Tyr Arg 
    1160                 1165                 1170             


Phe Val  Xaa Arg Ala Ser Val  Glu Glu Arg Ile Xaa  Gln Val Ala 
    1175                 1180                 1185             


Lys Lys  Lys Met Met Leu Xaa  His Leu Val Val Arg  Pro Gly Leu 
    1190                 1195                 1200             


Gly Ser  Lys Xaa Gly Ser Met  Ser Lys Gln Glu Leu  Asp Asp Ile 
    1205                 1210                 1215             


Leu Lys  Phe Gly Xaa Glu Glu  Leu Phe Lys Asp Glu  Ala Xaa Asp 
    1220                 1225                 1230             


Gly Gly  Gly Asp Asn Lys Glu  Gly Glu Asp Ser Ser  Val Ile His 
    1235                 1240                 1245             


Tyr Asp  Asp Lys Ala Ile Glu  Arg Leu Leu Asp Arg  Asn Gln Asp 
    1250                 1255                 1260             


Glu Xaa  Glu Asp Xaa Glu Leu  Gln Gly Met Asn Glu  Tyr Leu Ser 
    1265                 1270                 1275             


Ser Phe  Lys Val Ala Gln Tyr  Val Val Arg Glu Glu  Glu Met Gly 
    1280                 1285                 1290             


Glu Glu  Glu Glu Val Glu Arg  Glu Ile Ile Lys Gln  Glu Glu Ser 
    1295                 1300                 1305             


Val Asp  Pro Asp Tyr Trp Glu  Lys Leu Leu Arg His  His Tyr Glu 
    1310                 1315                 1320             


Gln Gln  Gln Glu Asp Leu Ala  Arg Asn Leu Gly Lys  Gly Lys Arg 
    1325                 1330                 1335             


Ile Arg  Lys Gln Val Asn Tyr  Asn Asp Gly Ser Gln  Glu Asp Arg 
    1340                 1345                 1350             


Asp Trp  Gln Asp Asp Gln Ser  Asp Asn Gln Ser Asp  Tyr Ser Val 
    1355                 1360                 1365             


Ala Ser  Glu Glu Gly Asp Glu  Asp Phe Asp Glu Arg  Ser Glu Ala 
    1370                 1375                 1380             


Pro Arg  Arg Pro Ser Arg Lys  Gly Leu Arg Asn Asp  Lys Asp Lys 
    1385                 1390                 1395             


Pro Leu  Pro Pro Leu Leu Ala  Arg Val Gly Gly Asn  Ile Glu Val 
    1400                 1405                 1410             


Leu Gly  Phe Asn Ala Arg Gln  Arg Lys Ala Phe Leu  Asn Ala Ile 
    1415                 1420                 1425             


Met Arg  Tyr Gly Met Pro Pro  Gln Asp Ala Phe Xaa  Xaa Gln Trp 
    1430                 1435                 1440             


Leu Val  Arg Asp Leu Arg Gly  Lys Ser Glu Lys Glu  Phe Lys Ala 
    1445                 1450                 1455             


Tyr Val  Ser Leu Phe Met Arg  His Leu Cys Glu Pro  Gly Ala Asp 
    1460                 1465                 1470             


Gly Ala  Glu Xaa Phe Ala Asp  Gly Val Pro Arg Glu  Gly Leu Ser 
    1475                 1480                 1485             


Arg Gln  His Val Leu Xaa Arg  Ile Gly Val Met Ser  Leu Ile Arg 
    1490                 1495                 1500             


Lys Lys  Val Gln Glu Phe Glu  His Val Asn Gly Arg  Trp Ser Met 
    1505                 1510                 1515             


Pro Glu  Leu Ala Glu Val Glu  Glu Asn Lys Lys Met  Ser Gln Pro 
    1520                 1525                 1530             


Gly Ser  Pro Ser Pro Lys Xaa  Pro Xaa Pro Ser Xaa  Pro Gly Asp 
    1535                 1540                 1545             


Xaa Gln  Pro Asn Xaa Pro Ala  Pro Val Pro Pro Ala  Glu Asp Gly 
    1550                 1555                 1560             


Ile Lys  Ile Glu Glu Asn Ser  Leu Lys Glu Glu Glu  Ser Ile Glu 
    1565                 1570                 1575             


Gly Glu  Lys Glu Val Lys Ser  Xaa Ala Pro Glu Xaa  Ala Ile Glu 
    1580                 1585                 1590             


Cys Xaa  Gln Ala Pro Ala Pro  Ala Ser Glu Asp Glu  Lys Val Val 
    1595                 1600                 1605             


Val Glu  Pro Pro Glu Gly Glu  Glu Lys Val Glu Lys  Ala Glu Val 
    1610                 1615                 1620             


Lys Glu  Arg Xaa Glu Glu Pro  Met Glu Xaa Glu Pro  Lys Gly Ala 
    1625                 1630                 1635             


Ala Asp  Val Glu Lys Val Glu  Glu Lys Ser Ala Ile  Asp Leu Xaa 
    1640                 1645                 1650             


Pro Ile  Val Val Glu Asp Lys  Glu Glu Lys Lys Glu  Glu Glu Glu 
    1655                 1660                 1665             


Lys Lys  Glu Val Met Leu Gln  Asn Gly Glu Xaa Pro  Lys Asp Leu 
    1670                 1675                 1680             


Asn Asp  Glu Lys Gln Lys Lys  Asn Ile Lys Gln Arg  Phe Met Phe 
    1685                 1690                 1695             


Asn Ile  Ala Asp Gly Gly Phe  Xaa Glu Leu His Ser  Leu Trp Gln 
    1700                 1705                 1710             


Asn Glu  Glu Arg Ala Ala Xaa  Val Xaa Lys Lys Xaa  Tyr Glu Ile 
    1715                 1720                 1725             


Trp His  Arg Arg His Asp Tyr  Trp Leu Leu Ala Gly  Ile Ile Asn 
    1730                 1735                 1740             


His Gly  Tyr Ala Arg Trp Gln  Asp Ile Gln Asn Asp  Pro Arg Tyr 
    1745                 1750                 1755             


Ala Ile  Leu Asn Glu Pro Phe  Lys Gly Glu Met Asn  Arg Gly Asn 
    1760                 1765                 1770             


Phe Leu  Glu Ile Lys Asn Lys  Phe Leu Ala Arg Arg  Phe Lys Leu 
    1775                 1780                 1785             


Leu Glu  Gln Ala Leu Val Ile  Glu Glu Gln Leu Arg  Arg Ala Ala 
    1790                 1795                 1800             


Tyr Leu  Asn Met Ser Glu Asp  Pro Ser His Pro Ser  Met Ala Leu 
    1805                 1810                 1815             


Asn Xaa  Arg Phe Ala Glu Val  Glu Cys Leu Ala Glu  Ser His Gln 
    1820                 1825                 1830             


His Leu  Ser Lys Glu Ser Met  Ala Gly Asn Lys Pro  Ala Asn Ala 
    1835                 1840                 1845             


Val Leu  His Lys Val Leu Lys  Gln Leu Glu Glu Leu  Leu Ser Asp 
    1850                 1855                 1860             


Met Lys  Ala Asp Val Xaa Arg  Leu Pro Ala Xaa Ile  Ala Arg Ile 
    1865                 1870                 1875             


Pro Pro  Val Ala Val Arg Leu  Gln Met Ser Glu Arg  Asn Ile Leu 
    1880                 1885                 1890             


Ser Arg  Leu Ala Asn Arg Ala  Pro Glu Pro Xaa Pro  Gln Gln Val 
    1895                 1900                 1905             


Ala Gln  Gln Gln 
    1910         


<210> 5996
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<400> 5996
Met Leu Asp Leu Leu Glu Asp Phe Leu Glu Tyr Glu Gly Tyr Lys Tyr 
1               5                   10                  15      


Glu Arg Ile Asp Gly Gly Ile Xaa Gly Gly Leu Arg Gln Glu Ala Ile 
            20                  25                  30          


Asp Arg Phe Asn Ala Pro Gly Ala Gln Gln Phe Cys Phe Leu Leu Ser 
        35                  40                  45              


Xaa Arg Ala Gly Gly Leu Gly Ile Asn Leu Ala Xaa Ala Asp Xaa Val 
    50                  55                  60                  


Ile Ile Tyr Asp Ser Asp Trp Asn Pro His Asn Asp Ile Gln Val Cys 
65                  70                  75                  80  


Ala Ala Ala Ala His His Pro Pro Arg Gly Pro Leu Ile Pro Gly Leu 
                85                  90                  95      


Arg Pro Ser Ala Ala Pro Xaa Ala Ser Ala Arg Xaa Arg Arg 
            100                 105                 110 


<210> 5997
<211> 1225
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1179)..(1179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1222)..(1222)
<223> Selenocysteine

<400> 5997
Met Arg Gly Pro Val Gly Xaa Glu Glu Glu Leu Pro Arg Leu Phe Ala 
1               5                   10                  15      


Glu Glu Met Glu Asn Glu Asp Glu Met Ser Glu Glu Glu Asp Gly Gly 
            20                  25                  30          


Leu Glu Ala Phe Asp Asp Phe Phe Pro Val Glu Pro Val Ser Leu Pro 
        35                  40                  45              


Lys Lys Lys Lys Pro Lys Lys Leu Lys Glu Asn Lys Cys Lys Gly Lys 
    50                  55                  60                  


Arg Lys Lys Lys Glu Gly Ser Asn Asp Glu Leu Ser Glu Asn Glu Glu 
65                  70                  75                  80  


Asp Leu Glu Glu Lys Ser Glu Ser Glu Gly Ser Asp Tyr Ser Pro Asn 
                85                  90                  95      


Lys Lys Lys Lys Lys Lys Leu Lys Asp Lys Lys Glu Lys Lys Ala Lys 
            100                 105                 110         


Arg Lys Lys Lys Asp Glu Asp Glu Asp Asp Asn Asp Asp Gly Cys Leu 
        115                 120                 125             


Lys Glu Pro Lys Ser Ser Gly Gln Leu Met Ala Glu Trp Gly Leu Asp 
    130                 135                 140                 


Asp Val Asp Tyr Leu Phe Ser Glu Glu Asp Tyr His Xaa Leu Xaa Asn 
145                 150                 155                 160 


Tyr Lys Ala Phe Ser Gln Phe Leu Arg Pro Leu Ile Ala Lys Lys Asn 
                165                 170                 175     


Pro Lys Ile Pro Met Ser Lys Met Met Xaa Val Leu Gly Ala Lys Trp 
            180                 185                 190         


Arg Glu Phe Ser Ala Asn Asn Pro Phe Lys Gly Ser Ser Ala Ala Ala 
        195                 200                 205             


Ala Ala Ala Ala Val Ala Ala Ala Val Glu Xaa Val Xaa Ile Ser Pro 
    210                 215                 220                 


Pro Leu Ala Val Ser Pro Pro Gln Val Pro Gln Pro Val Pro Ile Arg 
225                 230                 235                 240 


Lys Ala Lys Xaa Lys Glu Gly Lys Gly Pro Gly Val Arg Lys Lys Ile 
                245                 250                 255     


Lys Gly Ser Lys Asp Gly Lys Lys Lys Gly Lys Gly Lys Lys Xaa Ala 
            260                 265                 270         


Gly Leu Lys Phe Arg Phe Gly Gly Ile Ser Asn Lys Arg Lys Lys Gly 
        275                 280                 285             


Ser Ser Ser Glu Glu Asp Glu Arg Glu Glu Ser Asp Phe Asp Ser Ala 
    290                 295                 300                 


Ser Ile His Ser Ala Ser Val Arg Ser Glu Cys Ser Ala Ala Leu Gly 
305                 310                 315                 320 


Lys Lys Ser Lys Arg Arg Arg Lys Lys Lys Arg Ile Asp Asp Gly Asp 
                325                 330                 335     


Gly Tyr Glu Xaa Asp His Gln Asp Tyr Cys Glu Val Cys Gln Gln Gly 
            340                 345                 350         


Gly Glu Ile Ile Leu Cys Asp Xaa Cys Pro Arg Ala Tyr His Leu Val 
        355                 360                 365             


Cys Leu Asp Pro Glu Leu Glu Lys Ala Pro Glu Gly Lys Trp Ser Cys 
    370                 375                 380                 


Pro His Cys Glu Lys Glu Gly Ile Gln Trp Glu Pro Lys Asp Asp Asp 
385                 390                 395                 400 


Asp Glu Glu Glu Glu Gly Gly Cys Glu Glu Glu Glu Asp Asp His Met 
                405                 410                 415     


Glu Phe Cys Arg Val Cys Lys Asp Gly Gly Glu Leu Leu Cys Cys Asp 
            420                 425                 430         


Ala Cys Pro Ser Ser Tyr His Leu His Cys Leu Asn Pro Pro Leu Pro 
        435                 440                 445             


Glu Ile Pro Asn Gly Glu Trp Leu Cys Pro Arg Cys Xaa Cys Pro Pro 
    450                 455                 460                 


Leu Lys Gly Lys Val Gln Arg Ile Leu His Trp Arg Trp Xaa Glu Pro 
465                 470                 475                 480 


Pro Ala Pro Phe Met Val Gly Leu Pro Gly Pro Asp Val Glu Pro Ser 
                485                 490                 495     


Leu Pro Pro Pro Lys Pro Leu Glu Gly Ile Pro Glu Arg Glu Phe Phe 
            500                 505                 510         


Val Lys Trp Ala Gly Leu Ser Tyr Trp His Cys Ser Trp Val Lys Glu 
        515                 520                 525             


Leu Gln Leu Glu Leu Tyr His Xaa Val Met Tyr Arg Asn Tyr Gln Arg 
    530                 535                 540                 


Lys Asn Asp Met Asp Glu Pro Pro Pro Phe Asp Tyr Gly Ser Gly Asp 
545                 550                 555                 560 


Glu Asp Gly Lys Ser Glu Lys Arg Lys Asn Lys Asp Pro Leu Tyr Ala 
                565                 570                 575     


Lys Met Glu Glu Arg Phe Tyr Arg Tyr Gly Ile Lys Pro Glu Trp Met 
            580                 585                 590         


Met Ile His Arg Ile Leu Asn His Ser Phe Asp Lys Lys Gly Asp Val 
        595                 600                 605             


His Tyr Leu Ile Lys Trp Lys Asp Leu Pro Tyr Asp Gln Cys Xaa Trp 
    610                 615                 620                 


Glu Ile Asp Asp Ile Asp Ile Pro Tyr Tyr Asp Asn Leu Lys Gln Ala 
625                 630                 635                 640 


Tyr Trp Gly His Arg Glu Leu Met Leu Gly Glu Asp Xaa Arg Leu Pro 
                645                 650                 655     


Lys Arg Leu Leu Lys Lys Gly Lys Lys Leu Arg Asp Asp Lys Gln Glu 
            660                 665                 670         


Lys Pro Pro Asp Xaa Pro Ile Val Asp Pro Xaa Val Lys Phe Asp Lys 
        675                 680                 685             


Gln Pro Trp Tyr Ile Asp Ser Xaa Gly Gly Xaa Leu His Pro Tyr Gln 
    690                 695                 700                 


Leu Glu Gly Leu Asn Trp Leu Arg Phe Ser Trp Ala Gln Gly Xaa Asp 
705                 710                 715                 720 


Xaa Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Xaa Val Gln Xaa Ile 
                725                 730                 735     


Val Phe Leu Tyr Ser Leu Tyr Lys Glu Gly His Ser Lys Gly Pro Tyr 
            740                 745                 750         


Leu Val Ser Ala Pro Leu Ser Xaa Ile Ile Asn Trp Glu Arg Glu Phe 
        755                 760                 765             


Glu Met Trp Ala Pro Asp Phe Tyr Val Val Xaa Tyr Xaa Gly Asp Lys 
    770                 775                 780                 


Glu Ser Arg Ser Val Ile Arg Glu Asn Glu Phe Ser Phe Glu Asp Asn 
785                 790                 795                 800 


Ala Ile Arg Ser Gly Lys Lys Val Phe Arg Met Lys Lys Glu Val Gln 
                805                 810                 815     


Ile Lys Phe His Val Leu Leu Xaa Ser Tyr Glu Leu Ile Xaa Ile Asp 
            820                 825                 830         


Gln Ala Ile Leu Gly Ser Ile Glu Trp Ala Cys Leu Val Val Asp Glu 
        835                 840                 845             


Ala His Arg Leu Lys Asn Asn Gln Ser Lys Phe Phe Arg Val Leu Asn 
    850                 855                 860                 


Ser Tyr Lys Ile Asp Tyr Lys Leu Leu Leu Xaa Gly Xaa Pro Leu Gln 
865                 870                 875                 880 


Asn Asn Leu Glu Glu Leu Phe His Leu Leu Asn Phe Leu Xaa Pro Glu 
                885                 890                 895     


Arg Phe Asn Asn Leu Glu Gly Phe Leu Glu Glu Phe Ala Asp Ile Ser 
            900                 905                 910         


Lys Glu Asp Gln Ile Lys Lys Leu His Asp Leu Leu Gly Pro His Met 
        915                 920                 925             


Leu Arg Arg Leu Lys Ala Asp Val Phe Lys Asn Met Pro Ala Lys Xaa 
    930                 935                 940                 


Glu Leu Ile Val Arg Val Glu Leu Ser Gln Met Gln Lys Lys Tyr Tyr 
945                 950                 955                 960 


Lys Phe Ile Leu Xaa Arg Asn Phe Glu Ala Leu Asn Ser Lys Gly Gly 
                965                 970                 975     


Gly Asn Gln Val Ser Leu Leu Asn Ile Met Met Asp Leu Lys Lys Cys 
            980                 985                 990         


Cys Asn His Pro Tyr Leu Phe Pro  Val Ala Ala Val Glu  Ala Pro Val 
        995                 1000                 1005             


Leu Pro  Asn Gly Ser Tyr Asp  Gly Ser Ser Leu Val  Lys Ser Ser 
    1010                 1015                 1020             


Gly Lys  Leu Met Leu Leu Gln  Lys Met Leu Lys Lys  Leu Arg Asp 
    1025                 1030                 1035             


Glu Gly  His Arg Val Leu Ile  Phe Ser Gln Met Xaa  Lys Met Leu 
    1040                 1045                 1050             


Asp Leu  Leu Glu Asp Phe Leu  Glu Tyr Glu Gly Tyr  Lys Tyr Glu 
    1055                 1060                 1065             


Arg Ile  Asp Gly Gly Ile Xaa  Gly Gly Leu Arg Gln  Glu Ala Ile 
    1070                 1075                 1080             


Asp Arg  Phe Asn Ala Pro Gly  Ala Gln Gln Phe Cys  Phe Leu Leu 
    1085                 1090                 1095             


Ser Xaa  Arg Ala Gly Gly Leu  Gly Ile Asn Leu Ala  Xaa Ala Asp 
    1100                 1105                 1110             


Xaa Val  Ile Ile Tyr Asp Ser  Asp Trp Asn Pro His  Asn Asp Ile 
    1115                 1120                 1125             


Gln Ala  Phe Ser Arg Ala His  Arg Ile Gly Gln Xaa  Lys Trp Lys 
    1130                 1135                 1140             


Pro Ser  Trp Ala Xaa Trp Met  Arg Lys Xaa Pro Gly  His Arg Ser 
    1145                 1150                 1155             


Gln Gly  Ser Pro Trp Lys Ser  Arg Pro Phe Gln Pro  Pro Trp Ile 
    1160                 1165                 1170             


Glu Trp  Arg Val Arg Xaa Ser  Xaa Arg Ala Gln Pro  Ala Arg Arg 
    1175                 1180                 1185             


Glu Pro  Glu Arg Ser Gly Gln  Arg Arg Arg Arg Arg  Pro Arg Pro 
    1190                 1195                 1200             


Pro Arg  Ser Ser Cys Arg Glu  Arg Arg Cys Phe Leu  Arg Arg Arg 
    1205                 1210                 1215             


Arg Ser  Trp Xaa Ser Trp Ser  
    1220                 1225 


<210> 5998
<211> 1954
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1100)..(1100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1197)..(1197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1273)..(1273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1276)..(1276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1485)..(1485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1502)..(1502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1526)..(1526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1549)..(1549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1625)..(1625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1670)..(1670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1680)..(1680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1713)..(1713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1717)..(1717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1750)..(1750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1815)..(1815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1876)..(1876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1904)..(1904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1911)..(1911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1952)..(1952)
<223> Selenocysteine

<400> 5998
Met Arg Gly Pro Val Gly Xaa Glu Glu Glu Leu Pro Arg Leu Phe Ala 
1               5                   10                  15      


Glu Glu Met Glu Asn Glu Asp Glu Met Ser Glu Glu Glu Asp Gly Gly 
            20                  25                  30          


Leu Glu Ala Phe Asp Asp Phe Phe Pro Val Glu Pro Val Ser Leu Pro 
        35                  40                  45              


Lys Lys Lys Lys Pro Lys Lys Leu Lys Glu Asn Lys Cys Lys Gly Lys 
    50                  55                  60                  


Arg Lys Lys Lys Glu Gly Ser Asn Asp Glu Leu Ser Glu Asn Glu Glu 
65                  70                  75                  80  


Asp Leu Glu Glu Lys Ser Glu Ser Glu Gly Ser Asp Tyr Ser Pro Asn 
                85                  90                  95      


Lys Lys Lys Lys Lys Lys Leu Lys Asp Lys Lys Glu Lys Lys Ala Lys 
            100                 105                 110         


Arg Lys Lys Lys Asp Glu Asp Glu Asp Asp Asn Asp Asp Gly Cys Leu 
        115                 120                 125             


Lys Glu Pro Lys Ser Ser Gly Gln Leu Met Ala Glu Trp Gly Leu Asp 
    130                 135                 140                 


Asp Val Asp Tyr Leu Phe Ser Glu Glu Asp Tyr His Xaa Leu Xaa Asn 
145                 150                 155                 160 


Tyr Lys Ala Phe Ser Gln Phe Leu Arg Pro Leu Ile Ala Lys Lys Asn 
                165                 170                 175     


Pro Lys Ile Pro Met Ser Lys Met Met Xaa Val Leu Gly Ala Lys Trp 
            180                 185                 190         


Arg Glu Phe Ser Ala Asn Asn Pro Phe Lys Gly Ser Ser Ala Ala Ala 
        195                 200                 205             


Ala Ala Ala Ala Val Ala Ala Ala Val Glu Xaa Val Xaa Ile Ser Pro 
    210                 215                 220                 


Pro Leu Ala Val Ser Pro Pro Gln Val Pro Gln Pro Val Pro Ile Arg 
225                 230                 235                 240 


Lys Ala Lys Xaa Lys Glu Gly Lys Gly Pro Gly Val Arg Lys Lys Ile 
                245                 250                 255     


Lys Gly Ser Lys Asp Gly Lys Lys Lys Gly Lys Gly Lys Lys Xaa Ala 
            260                 265                 270         


Gly Leu Lys Phe Arg Phe Gly Gly Ile Ser Asn Lys Arg Lys Lys Gly 
        275                 280                 285             


Ser Ser Ser Glu Glu Asp Glu Arg Glu Glu Ser Asp Phe Asp Ser Ala 
    290                 295                 300                 


Ser Ile His Ser Ala Ser Val Arg Ser Glu Cys Ser Ala Ala Leu Gly 
305                 310                 315                 320 


Lys Lys Ser Lys Arg Arg Arg Lys Lys Lys Arg Ile Asp Asp Gly Asp 
                325                 330                 335     


Gly Tyr Glu Xaa Asp His Gln Asp Tyr Cys Glu Val Cys Gln Gln Gly 
            340                 345                 350         


Gly Glu Ile Ile Leu Cys Asp Xaa Cys Pro Arg Ala Tyr His Leu Val 
        355                 360                 365             


Cys Leu Asp Pro Glu Leu Glu Lys Ala Pro Glu Gly Lys Trp Ser Cys 
    370                 375                 380                 


Pro His Cys Glu Lys Glu Gly Ile Gln Trp Glu Pro Lys Asp Asp Asp 
385                 390                 395                 400 


Asp Glu Glu Glu Glu Gly Gly Cys Glu Glu Glu Glu Asp Asp His Met 
                405                 410                 415     


Glu Phe Cys Arg Val Cys Lys Asp Gly Gly Glu Leu Leu Cys Cys Asp 
            420                 425                 430         


Ala Cys Pro Ser Ser Tyr His Leu His Cys Leu Asn Pro Pro Leu Pro 
        435                 440                 445             


Glu Ile Pro Asn Gly Glu Trp Leu Cys Pro Arg Cys Xaa Cys Pro Pro 
    450                 455                 460                 


Leu Lys Gly Lys Val Gln Arg Ile Leu His Trp Arg Trp Xaa Glu Pro 
465                 470                 475                 480 


Pro Ala Pro Phe Met Val Gly Leu Pro Gly Pro Asp Val Glu Pro Ser 
                485                 490                 495     


Leu Pro Pro Pro Lys Pro Leu Glu Gly Ile Pro Glu Arg Glu Phe Phe 
            500                 505                 510         


Val Lys Trp Ala Gly Leu Ser Tyr Trp His Cys Ser Trp Val Lys Glu 
        515                 520                 525             


Leu Gln Leu Glu Leu Tyr His Xaa Val Met Tyr Arg Asn Tyr Gln Arg 
    530                 535                 540                 


Lys Asn Asp Met Asp Glu Pro Pro Pro Phe Asp Tyr Gly Ser Gly Asp 
545                 550                 555                 560 


Glu Asp Gly Lys Ser Glu Lys Arg Lys Asn Lys Asp Pro Leu Tyr Ala 
                565                 570                 575     


Lys Met Glu Glu Arg Phe Tyr Arg Tyr Gly Ile Lys Pro Glu Trp Met 
            580                 585                 590         


Met Ile His Arg Ile Leu Asn His Ser Phe Asp Lys Lys Gly Asp Val 
        595                 600                 605             


His Tyr Leu Ile Lys Trp Lys Asp Leu Pro Tyr Asp Gln Cys Xaa Trp 
    610                 615                 620                 


Glu Ile Asp Asp Ile Asp Ile Pro Tyr Tyr Asp Asn Leu Lys Gln Ala 
625                 630                 635                 640 


Tyr Trp Gly His Arg Glu Leu Met Leu Gly Glu Asp Xaa Arg Leu Pro 
                645                 650                 655     


Lys Arg Leu Leu Lys Lys Gly Lys Lys Leu Arg Asp Asp Lys Gln Glu 
            660                 665                 670         


Lys Pro Pro Asp Xaa Pro Ile Val Asp Pro Xaa Val Lys Phe Asp Lys 
        675                 680                 685             


Gln Pro Trp Tyr Ile Asp Ser Xaa Gly Gly Xaa Leu His Pro Tyr Gln 
    690                 695                 700                 


Leu Glu Gly Leu Asn Trp Leu Arg Phe Ser Trp Ala Gln Gly Xaa Asp 
705                 710                 715                 720 


Xaa Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Xaa Val Gln Xaa Ile 
                725                 730                 735     


Val Phe Leu Tyr Ser Leu Tyr Lys Glu Gly His Ser Lys Gly Pro Tyr 
            740                 745                 750         


Leu Val Ser Ala Pro Leu Ser Xaa Ile Ile Asn Trp Glu Arg Glu Phe 
        755                 760                 765             


Glu Met Trp Ala Pro Asp Phe Tyr Val Val Xaa Tyr Xaa Gly Asp Lys 
    770                 775                 780                 


Glu Ser Arg Ser Val Ile Arg Glu Asn Glu Phe Ser Phe Glu Asp Asn 
785                 790                 795                 800 


Ala Ile Arg Ser Gly Lys Lys Val Phe Arg Met Lys Lys Glu Val Gln 
                805                 810                 815     


Ile Lys Phe His Val Leu Leu Xaa Ser Tyr Glu Leu Ile Xaa Ile Asp 
            820                 825                 830         


Gln Ala Ile Leu Gly Ser Ile Glu Trp Ala Cys Leu Val Val Asp Glu 
        835                 840                 845             


Ala His Arg Leu Lys Asn Asn Gln Ser Lys Phe Phe Arg Val Leu Asn 
    850                 855                 860                 


Ser Tyr Lys Ile Asp Tyr Lys Leu Leu Leu Xaa Gly Xaa Pro Leu Gln 
865                 870                 875                 880 


Asn Asn Leu Glu Glu Leu Phe His Leu Leu Asn Phe Leu Xaa Pro Glu 
                885                 890                 895     


Arg Phe Asn Asn Leu Glu Gly Phe Leu Glu Glu Phe Ala Asp Ile Ser 
            900                 905                 910         


Lys Glu Asp Gln Ile Lys Lys Leu His Asp Leu Leu Gly Pro His Met 
        915                 920                 925             


Leu Arg Arg Leu Lys Ala Asp Val Phe Lys Asn Met Pro Ala Lys Xaa 
    930                 935                 940                 


Glu Leu Ile Val Arg Val Glu Leu Ser Gln Met Gln Lys Lys Tyr Tyr 
945                 950                 955                 960 


Lys Phe Ile Leu Xaa Arg Asn Phe Glu Ala Leu Asn Ser Lys Gly Gly 
                965                 970                 975     


Gly Asn Gln Val Ser Leu Leu Asn Ile Met Met Asp Leu Lys Lys Cys 
            980                 985                 990         


Cys Asn His Pro Tyr Leu Phe Pro  Val Ala Ala Val Glu  Ala Pro Val 
        995                 1000                 1005             


Leu Pro  Asn Gly Ser Tyr Asp  Gly Ser Ser Leu Val  Lys Ser Ser 
    1010                 1015                 1020             


Gly Lys  Leu Met Leu Leu Gln  Lys Met Leu Lys Lys  Leu Arg Asp 
    1025                 1030                 1035             


Glu Gly  His Arg Val Leu Ile  Phe Ser Gln Met Xaa  Lys Met Leu 
    1040                 1045                 1050             


Asp Leu  Leu Glu Asp Phe Leu  Glu Tyr Glu Gly Tyr  Lys Tyr Glu 
    1055                 1060                 1065             


Arg Ile  Asp Gly Gly Ile Xaa  Gly Gly Leu Arg Gln  Glu Ala Ile 
    1070                 1075                 1080             


Asp Arg  Phe Asn Ala Pro Gly  Ala Gln Gln Phe Cys  Phe Leu Leu 
    1085                 1090                 1095             


Ser Xaa  Arg Ala Gly Gly Leu  Gly Ile Asn Leu Ala  Xaa Ala Asp 
    1100                 1105                 1110             


Xaa Val  Ile Ile Tyr Asp Ser  Asp Trp Asn Pro His  Asn Asp Ile 
    1115                 1120                 1125             


Gln Ala  Phe Ser Arg Ala His  Arg Ile Gly Gln Asn  Lys Lys Val 
    1130                 1135                 1140             


Met Ile  Tyr Arg Phe Val Xaa  Arg Ala Ser Val Glu  Glu Arg Ile 
    1145                 1150                 1155             


Xaa Gln  Val Ala Lys Arg Lys  Met Met Leu Xaa His  Leu Val Val 
    1160                 1165                 1170             


Arg Pro  Gly Leu Gly Ser Lys  Ser Gly Ser Met Xaa  Lys Gln Glu 
    1175                 1180                 1185             


Leu Asp  Asp Ile Leu Lys Phe  Gly Xaa Glu Glu Leu  Phe Lys Asp 
    1190                 1195                 1200             


Asp Val  Glu Gly Met Met Ser  Gln Gly Gln Arg Pro  Val Xaa Pro 
    1205                 1210                 1215             


Ile Pro  Asp Val Gln Ser Ser  Lys Gly Gly Asn Leu  Ala Ala Ser 
    1220                 1225                 1230             


Ala Lys  Lys Lys His Gly Ser  Xaa Pro Pro Gly Asp  Asn Lys Asp 
    1235                 1240                 1245             


Val Glu  Asp Ser Ser Val Ile  His Tyr Asp Asp Ala  Ala Ile Ser 
    1250                 1255                 1260             


Lys Leu  Leu Asp Arg Asn Gln  Asp Ala Xaa Asp Asp  Xaa Glu Leu 
    1265                 1270                 1275             


Gln Asn  Met Asn Glu Tyr Leu  Ser Ser Phe Lys Val  Ala Gln Tyr 
    1280                 1285                 1290             


Val Val  Arg Glu Glu Asp Gly  Val Glu Glu Val Glu  Arg Glu Ile 
    1295                 1300                 1305             


Ile Lys  Gln Glu Glu Asn Val  Asp Pro Asp Tyr Trp  Glu Lys Leu 
    1310                 1315                 1320             


Leu Arg  His His Tyr Glu Gln  Gln Gln Glu Asp Leu  Ala Arg Asn 
    1325                 1330                 1335             


Leu Gly  Lys Gly Lys Arg Ile  Arg Lys Gln Val Asn  Tyr Asn Asp 
    1340                 1345                 1350             


Ala Ser  Gln Glu Asp Gln Glu  Trp Gln Asp Glu Leu  Ser Asp Asn 
    1355                 1360                 1365             


Gln Ser  Glu Tyr Ser Ile Gly  Ser Glu Asp Glu Asp  Glu Asp Phe 
    1370                 1375                 1380             


Glu Glu  Arg Pro Glu Gly Gln  Ser Gly Arg Arg Gln  Ser Arg Arg 
    1385                 1390                 1395             


Gln Leu  Lys Ser Asp Arg Asp  Lys Pro Leu Pro Pro  Leu Leu Ala 
    1400                 1405                 1410             


Arg Val  Gly Gly Asn Ile Glu  Val Leu Gly Phe Asn  Ala Arg Gln 
    1415                 1420                 1425             


Arg Lys  Ala Phe Leu Asn Ala  Ile Met Arg Trp Gly  Met Pro Pro 
    1430                 1435                 1440             


Gln Asp  Ala Phe Asn Ser His  Trp Leu Val Arg Asp  Leu Arg Gly 
    1445                 1450                 1455             


Lys Ser  Glu Lys Glu Phe Arg  Ala Tyr Val Ser Leu  Phe Met Arg 
    1460                 1465                 1470             


His Leu  Cys Glu Pro Gly Ala  Asp Gly Ala Glu Xaa  Phe Ala Asp 
    1475                 1480                 1485             


Gly Val  Pro Arg Glu Gly Leu  Ser Arg Gln His Val  Leu Xaa Arg 
    1490                 1495                 1500             


Ile Gly  Val Met Ser Leu Val  Arg Lys Lys Val Gln  Glu Phe Glu 
    1505                 1510                 1515             


His Val  Asn Gly Lys Tyr Ser  Xaa Pro Asp Leu Ile  Pro Glu Gly 
    1520                 1525                 1530             


Pro Glu  Gly Lys Lys Ser Gly  Glu Val Ile Ser Ser  Asp Pro Asn 
    1535                 1540                 1545             


Xaa Pro  Val Pro Ala Ser Pro  Ala His Leu Leu Pro  Ala Pro Leu 
    1550                 1555                 1560             


Gly Leu  Pro Asp Lys Met Glu  Ala Gln Leu Gly Tyr  Met Asp Glu 
    1565                 1570                 1575             


Lys Asp  Pro Gly Ala Gln Lys  Pro Arg Gln Pro Leu  Glu Val Gln 
    1580                 1585                 1590             


Ala Leu  Pro Ala Ala Leu Asp  Arg Val Glu Ser Glu  Asp Lys His 
    1595                 1600                 1605             


Glu Ser  Pro Ala Ser Lys Glu  Arg Ala Arg Glu Glu  Arg Pro Glu 
    1610                 1615                 1620             


Glu Xaa  Glu Lys Ala Pro Pro  Ser Pro Glu Gln Leu  Pro Arg Glu 
    1625                 1630                 1635             


Glu Val  Leu Pro Glu Lys Glu  Lys Ile Leu Asp Lys  Leu Glu Leu 
    1640                 1645                 1650             


Ser Leu  Ile His Ser Arg Gly  Asp Ser Ser Glu Leu  Arg Pro Asp 
    1655                 1660                 1665             


Asp Xaa  Lys Ala Glu Glu Lys  Glu Pro Ile Glu Xaa  Gln Gln Asn 
    1670                 1675                 1680             


Gly Asp  Lys Glu Glu Asp Asp  Glu Gly Lys Lys Glu  Asp Lys Lys 
    1685                 1690                 1695             


Gly Lys  Phe Lys Phe Met Phe  Asn Ile Ala Asp Gly  Gly Phe Xaa 
    1700                 1705                 1710             


Glu Leu  His Xaa Leu Trp Gln  Asn Glu Glu Arg Ala  Ala Val Ser 
    1715                 1720                 1725             


Ser Gly  Lys Ile Tyr Asp Ile  Trp His Arg Arg His  Asp Tyr Trp 
    1730                 1735                 1740             


Leu Leu  Ala Gly Ile Val Xaa  His Gly Tyr Ala Arg  Trp Gln Asp 
    1745                 1750                 1755             


Ile Gln  Asn Asp Pro Arg Tyr  Met Ile Leu Asn Glu  Pro Phe Lys 
    1760                 1765                 1770             


Ser Glu  Val His Lys Gly Asn  Tyr Leu Glu Met Lys  Asn Lys Phe 
    1775                 1780                 1785             


Leu Ala  Arg Arg Phe Lys Leu  Leu Glu Gln Ala Leu  Val Ile Glu 
    1790                 1795                 1800             


Glu Gln  Leu Arg Arg Ala Ala  Tyr Leu Asn Met Xaa  Gln Asp Pro 
    1805                 1810                 1815             


Asn His  Pro Ala Met Ala Leu  Asn Ala Arg Leu Ala  Glu Val Glu 
    1820                 1825                 1830             


Cys Leu  Ala Glu Ser His Gln  His Leu Ser Lys Glu  Ser Leu Ala 
    1835                 1840                 1845             


Gly Asn  Lys Pro Ala Asn Ala  Val Leu His Lys Val  Leu Asn Gln 
    1850                 1855                 1860             


Leu Glu  Glu Leu Leu Ser Asp  Met Lys Ala Asp Val  Xaa Arg Leu 
    1865                 1870                 1875             


Pro Ser  Met Leu Ser Arg Ile  Pro Pro Val Ala Ala  Arg Leu Gln 
    1880                 1885                 1890             


Met Ser  Glu Arg Ser Ile Leu  Ser Arg Leu Xaa Asn  Arg Ala Gly 
    1895                 1900                 1905             


Asp Pro  Xaa Ile Gln Gln Gly  Ala Phe Gly Ser Ser  Gln Met Tyr 
    1910                 1915                 1920             


Ser Asn  Asn Phe Gly Pro Asn  Phe Arg Gly Pro Gly  Pro Gly Gly 
    1925                 1930                 1935             


Ile Val  Asn Tyr Asn Gln Met  Pro Leu Gly Pro Tyr  Val Xaa Asp 
    1940                 1945                 1950             


Ile 
    


<210> 5999
<211> 127
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<400> 5999
Xaa Leu Ala Ala Ser Ala Lys Lys Lys His Gly Ser Xaa Pro Pro Gly 
1               5                   10                  15      


Asp Asn Lys Asp Val Glu Asp Ser Ser Val Ile His Tyr Asp Asp Ala 
            20                  25                  30          


Ala Ile Ser Lys Leu Leu Asp Arg Asn Gln Asp Ala Xaa Asp Asp Xaa 
        35                  40                  45              


Glu Leu Gln Asn Met Asn Glu Tyr Leu Ser Ser Phe Lys Val Ala Gln 
    50                  55                  60                  


Tyr Val Val Arg Glu Glu Asp Gly Val Leu Ser Pro Lys Ser Ser Leu 
65                  70                  75                  80  


Trp Val Ser Pro Gly Gly Leu Ser Val Ser Ser Ser Ala Pro His Pro 
                85                  90                  95      


Pro Cys Arg Pro Gly Gly Gly Gly Ala Gly Asn His Gln Ala Gly Gly 
            100                 105                 110         


Glu Arg Gly Pro Arg Leu Leu Gly Glu Ala Ala Ala Ala Pro Leu 
        115                 120                 125         


<210> 6000
<211> 90
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 6000
Xaa Gln Leu Glu Glu Leu Leu Ser Asp Met Lys Ala Asp Val Xaa Arg 
1               5                   10                  15      


Leu Pro Ser Met Leu Ser Arg Ile Pro Pro Val Ala Ala Arg Leu Gln 
            20                  25                  30          


Met Ser Glu Arg Ser Ile Leu Ser Arg Leu Xaa Asn Arg Ala Gly Asp 
        35                  40                  45              


Pro Xaa Ile Gln Gln Ile Ser Ser Arg Pro Arg Asp Phe Pro Val Leu 
    50                  55                  60                  


Gln Arg Ser Phe Pro Ala Glu Pro Arg Leu Pro Gly His Leu Pro Asp 
65                  70                  75                  80  


Pro His Gly Arg Glu Lys Leu Pro Pro Phe 
                85                  90  


<210> 6001
<211> 1060
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<400> 6001
Xaa Tyr Asp Gln Cys Xaa Trp Glu Ile Asp Asp Ile Asp Ile Pro Tyr 
1               5                   10                  15      


Tyr Asp Asn Leu Lys Gln Ala Tyr Trp Gly His Arg Glu Leu Met Leu 
            20                  25                  30          


Gly Glu Asp Xaa Arg Leu Pro Lys Arg Leu Leu Lys Lys Gly Lys Lys 
        35                  40                  45              


Leu Arg Asp Asp Lys Gln Glu Lys Pro Pro Asp Xaa Pro Ile Val Asp 
    50                  55                  60                  


Pro Xaa Val Lys Phe Asp Lys Gln Pro Trp Tyr Ile Asp Ser Xaa Gly 
65                  70                  75                  80  


Gly Xaa Leu His Pro Tyr Gln Leu Glu Gly Leu Asn Trp Leu Arg Phe 
                85                  90                  95      


Ser Trp Ala Gln Gly Xaa Asp Xaa Ile Leu Ala Asp Glu Met Gly Leu 
            100                 105                 110         


Gly Lys Xaa Val Gln Xaa Ile Val Phe Leu Tyr Ser Leu Tyr Lys Glu 
        115                 120                 125             


Gly His Ser Lys Gly Pro Tyr Leu Val Ser Ala Pro Leu Ser Xaa Ile 
    130                 135                 140                 


Ile Asn Trp Glu Arg Glu Phe Glu Met Trp Ala Pro Asp Phe Tyr Val 
145                 150                 155                 160 


Val Xaa Tyr Xaa Gly Asp Lys Glu Ser Arg Ser Val Ile Arg Glu Asn 
                165                 170                 175     


Glu Phe Ser Phe Glu Asp Asn Ala Ile Arg Ser Gly Lys Lys Val Phe 
            180                 185                 190         


Arg Met Lys Lys Glu Val Gln Ile Lys Phe His Val Leu Leu Xaa Ser 
        195                 200                 205             


Tyr Glu Leu Ile Xaa Ile Asp Gln Ala Ile Leu Gly Ser Ile Glu Trp 
    210                 215                 220                 


Ala Cys Leu Val Val Asp Glu Ala His Arg Leu Lys Asn Asn Gln Ser 
225                 230                 235                 240 


Lys Phe Phe Arg Val Leu Asn Ser Tyr Lys Ile Asp Tyr Lys Leu Leu 
                245                 250                 255     


Leu Xaa Gly Xaa Pro Leu Gln Asn Asn Leu Glu Glu Leu Phe His Leu 
            260                 265                 270         


Leu Asn Phe Leu Xaa Pro Glu Arg Phe Asn Asn Leu Glu Gly Phe Leu 
        275                 280                 285             


Glu Glu Phe Ala Asp Ile Ser Lys Glu Asp Gln Ile Lys Lys Leu His 
    290                 295                 300                 


Asp Leu Leu Gly Pro His Met Leu Arg Arg Leu Lys Ala Asp Val Phe 
305                 310                 315                 320 


Lys Asn Met Pro Ala Lys Xaa Glu Leu Ile Val Arg Val Glu Leu Ser 
                325                 330                 335     


Gln Met Gln Lys Lys Tyr Tyr Lys Phe Ile Leu Xaa Arg Asn Phe Glu 
            340                 345                 350         


Ala Leu Asn Ser Lys Gly Gly Gly Asn Gln Val Ser Leu Leu Asn Ile 
        355                 360                 365             


Met Met Asp Leu Lys Lys Cys Cys Asn His Pro Tyr Leu Phe Pro Val 
    370                 375                 380                 


Ala Ala Val Glu Ala Pro Val Leu Pro Asn Gly Ser Tyr Asp Gly Ser 
385                 390                 395                 400 


Ser Leu Val Lys Ser Ser Gly Lys Leu Met Leu Leu Gln Lys Met Leu 
                405                 410                 415     


Lys Lys Leu Arg Asp Glu Gly His Arg Val Leu Ile Phe Ser Gln Met 
            420                 425                 430         


Xaa Lys Met Leu Asp Leu Leu Glu Asp Phe Leu Glu Tyr Glu Gly Tyr 
        435                 440                 445             


Lys Tyr Glu Arg Ile Asp Gly Gly Ile Xaa Gly Gly Leu Arg Gln Glu 
    450                 455                 460                 


Ala Ile Asp Arg Phe Asn Ala Pro Gly Ala Gln Gln Phe Cys Phe Leu 
465                 470                 475                 480 


Leu Ser Xaa Arg Ala Gly Gly Leu Gly Ile Asn Leu Ala Xaa Ala Asp 
                485                 490                 495     


Xaa Val Ile Ile Tyr Asp Ser Asp Trp Asn Pro His Asn Asp Ile Gln 
            500                 505                 510         


Ala Phe Ser Arg Ala His Arg Ile Gly Gln Asn Lys Lys Val Met Ile 
        515                 520                 525             


Tyr Arg Phe Val Xaa Arg Ala Ser Val Glu Glu Arg Ile Xaa Gln Val 
    530                 535                 540                 


Ala Lys Arg Lys Met Met Leu Xaa His Leu Val Val Arg Pro Gly Leu 
545                 550                 555                 560 


Gly Ser Lys Ser Gly Ser Met Xaa Lys Gln Glu Leu Asp Asp Ile Leu 
                565                 570                 575     


Lys Phe Gly Xaa Glu Glu Leu Phe Lys Asp Asp Val Glu Gly Met Met 
            580                 585                 590         


Ser Gln Gly Gln Arg Pro Val Xaa Pro Ile Pro Asp Val Gln Ser Ser 
        595                 600                 605             


Lys Gly Gly Asn Leu Ala Ala Ser Ala Lys Lys Lys His Gly Ser Xaa 
    610                 615                 620                 


Pro Pro Gly Asp Asn Lys Asp Val Glu Asp Ser Ser Val Ile His Tyr 
625                 630                 635                 640 


Asp Asp Ala Ala Ile Ser Lys Leu Leu Asp Arg Asn Gln Asp Ala Xaa 
                645                 650                 655     


Asp Asp Xaa Glu Leu Gln Asn Met Asn Glu Tyr Leu Ser Ser Phe Lys 
            660                 665                 670         


Val Ala Gln Tyr Val Val Arg Glu Glu Asp Gly Val Glu Glu Val Glu 
        675                 680                 685             


Arg Glu Ile Ile Lys Gln Glu Glu Asn Val Asp Pro Asp Tyr Trp Glu 
    690                 695                 700                 


Lys Leu Leu Arg His His Tyr Glu Gln Gln Gln Glu Asp Leu Ala Arg 
705                 710                 715                 720 


Asn Leu Gly Lys Gly Lys Arg Ile Arg Lys Gln Val Asn Tyr Asn Asp 
                725                 730                 735     


Ala Ser Gln Glu Asp Gln Glu Trp Gln Asp Glu Leu Ser Asp Asn Gln 
            740                 745                 750         


Ser Glu Tyr Ser Ile Gly Ser Glu Asp Glu Asp Glu Asp Phe Glu Glu 
        755                 760                 765             


Arg Pro Glu Gly Gln Ser Gly Arg Arg Gln Ser Arg Arg Gln Leu Lys 
    770                 775                 780                 


Ser Asp Arg Asp Lys Pro Leu Pro Pro Leu Leu Ala Arg Val Gly Gly 
785                 790                 795                 800 


Asn Ile Glu Val Leu Gly Phe Asn Ala Arg Gln Arg Lys Ala Phe Leu 
                805                 810                 815     


Asn Ala Ile Met Arg Trp Gly Met Pro Pro Gln Asp Ala Phe Asn Ser 
            820                 825                 830         


His Trp Leu Val Arg Asp Leu Arg Gly Lys Ser Glu Lys Glu Phe Arg 
        835                 840                 845             


Ala Tyr Val Ser Leu Phe Met Arg His Leu Cys Glu Pro Gly Ala Asp 
    850                 855                 860                 


Gly Ala Glu Xaa Phe Ala Asp Gly Val Pro Arg Glu Gly Leu Ser Arg 
865                 870                 875                 880 


Gln His Val Leu Xaa Arg Ile Gly Val Met Ser Leu Val Arg Lys Lys 
                885                 890                 895     


Val Gln Glu Phe Glu His Val Asn Gly Lys Tyr Ser Xaa Pro Asp Leu 
            900                 905                 910         


Ile Pro Glu Gly Pro Glu Gly Lys Lys Ser Gly Glu Val Ile Ser Ser 
        915                 920                 925             


Asp Pro Asn Xaa Pro Val Pro Ala Ser Pro Ala His Leu Leu Pro Ala 
    930                 935                 940                 


Pro Leu Gly Leu Pro Asp Lys Met Glu Ala Gln Leu Gly Tyr Met Asp 
945                 950                 955                 960 


Glu Lys Asp Pro Gly Ala Gln Lys Pro Arg Gln Pro Leu Glu Val Gln 
                965                 970                 975     


Ala Leu Pro Ala Ala Leu Asp Arg Val Glu Ser Glu Asp Lys His Glu 
            980                 985                 990         


Ser Pro Ala Ser Lys Glu Arg Ala  Arg Glu Glu Arg Pro  Glu Glu Xaa 
        995                 1000                 1005             


Glu Lys  Ala Pro Pro Ser Pro  Glu Gln Leu Pro Arg  Ala Ser Cys 
    1010                 1015                 1020             


Ser Val  Xaa Gln Ala Gly Val  Gln Trp Arg His Leu  Gly Ser Trp 
    1025                 1030                 1035             


Glu Pro  Leu Ser Pro Arg Leu  Lys Arg Pro Ser His  Leu Ser Phe 
    1040                 1045                 1050             


Leu Asn  Arg Gly Gly Ala Ser  
    1055                 1060 


<210> 6002
<211> 373
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<400> 6002
Met Cys Gln Ser His Met Ile Gly Phe Cys Xaa Ser Ser Val Asn Glu 
1               5                   10                  15      


Glu Xaa Glu Xaa Gln Gly Asp Gln Ile Ser Cys Pro Asn Pro Xaa Xaa 
            20                  25                  30          


Leu Val Phe Arg Xaa Gln Ile Ser Ser Leu Pro Ser Leu Gln Leu Ser 
        35                  40                  45              


Asn Leu Lys Val Leu Asn His Ser Pro Met Ser Asp Ala Ser Val Asn 
    50                  55                  60                  


Phe Asp Tyr Lys Ser Pro Ser Pro Phe Asp Cys Ser Xaa Asp Gln Glu 
65                  70                  75                  80  


Glu Lys Ile Glu Asp Val Ala Ser His Cys Leu Pro Gln Lys Asp Leu 
                85                  90                  95      


Tyr Xaa Ala Glu Glu Glu Ala Ala Xaa Leu Phe Pro Arg Lys Met Xaa 
            100                 105                 110         


Ser His Asn Gly Met Glu Asp Ser Gly Gly Gly Gly Xaa Gly Val Lys 
        115                 120                 125             


Lys Lys Arg Lys Lys Lys Glu Pro Gly Asp Gln Glu Gly Ala Ala Lys 
    130                 135                 140                 


Gly Ser Lys Asp Arg Glu Pro Lys Pro Lys Arg Lys Arg Glu Pro Lys 
145                 150                 155                 160 


Glu Pro Lys Glu Pro Arg Lys Ala Lys Glu Pro Lys Lys Ala Lys Glu 
                165                 170                 175     


His Lys Glu Pro Lys Gln Lys Asp Gly Ala Lys Lys Ala Arg Lys Pro 
            180                 185                 190         


Arg Glu Ala Ser Gly Xaa Lys Glu Ala Lys Glu Lys Arg Ser Cys Xaa 
        195                 200                 205             


Asp Ser Ala Ala Arg Xaa Lys Ser Arg Lys Ala Ser Lys Glu Gln Gly 
    210                 215                 220                 


Pro Xaa Pro Val Glu Lys Lys Lys Lys Gly Lys Arg Lys Ser Glu Xaa 
225                 230                 235                 240 


Xaa Val Glu Ser Leu Glu Leu Asp Gln Gly Leu Xaa Asn Pro Ser Leu 
                245                 250                 255     


Arg Ser Pro Glu Glu Ser Xaa Glu Ser Xaa Asp Ser Gln Lys Arg Arg 
            260                 265                 270         


Ser Gly Arg Gln Val Lys Arg Arg Lys Tyr Asn Glu Asp Leu Asp Phe 
        275                 280                 285             


Lys Val Val Asp Asp Asp Gly Glu Xaa Ile Ala Val Leu Gly Ala Gly 
    290                 295                 300                 


Arg Xaa Ser Ala Leu Ser Ala Ser Xaa Leu Ala Trp Gln Ala Glu Glu 
305                 310                 315                 320 


Pro Pro Glu Asp Asp Ala Asn Ile Ile Glu Lys Ile Leu Ala Ser Lys 
                325                 330                 335     


Xaa Val Gln Glu Val His Pro Gly Glu Pro Pro Phe Asp Leu Glu Leu 
            340                 345                 350         


Phe Tyr Val Lys Tyr Arg Asn Leu Tyr Val Tyr Leu Lys Tyr Ser Leu 
        355                 360                 365             


Tyr Leu Gly Phe Ile 
    370             


<210> 6003
<211> 488
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<400> 6003
Met Glu Glu Leu Glu Lys Asp Pro Arg Ile Ala Gln Lys Ile Lys Arg 
1               5                   10                  15      


Phe Arg Asn Lys Gln Ala Gln Met Lys His Ile Phe Xaa Glu Pro Asp 
            20                  25                  30          


Glu Asp Leu Phe Asn Pro Asp Tyr Val Glu Val Asp Arg Ile Leu Glu 
        35                  40                  45              


Val Ala His Xaa Lys Asp Ala Glu Xaa Gly Glu Glu Val Xaa His Tyr 
    50                  55                  60                  


Leu Val Lys Trp Cys Ser Leu Pro Tyr Glu Glu Ser Xaa Trp Glu Leu 
65                  70                  75                  80  


Glu Glu Asp Val Asp Pro Ala Lys Val Lys Glu Phe Glu Ser Leu Gln 
                85                  90                  95      


Val Leu Pro Glu Ile Lys His Val Glu Arg Pro Ala Ser Asp Ser Trp 
            100                 105                 110         


Gln Lys Leu Glu Lys Ser Arg Glu Tyr Lys Asn Ser Asn Gln Leu Arg 
        115                 120                 125             


Glu Tyr Gln Leu Glu Gly Met Asn Trp Leu Leu Phe Asn Trp Tyr Asn 
    130                 135                 140                 


Arg Lys Asn Cys Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Xaa Ile 
145                 150                 155                 160 


Gln Ser Ile Xaa Phe Leu Ser Glu Ile Phe Leu Arg Gly Ile His Gly 
                165                 170                 175     


Pro Phe Leu Ile Ile Ala Pro Leu Ser Xaa Ile Xaa Asn Trp Glu Arg 
            180                 185                 190         


Glu Phe Arg Xaa Trp Xaa Glu Met Asn Ala Ile Val Tyr His Gly Ser 
        195                 200                 205             


Gln Ile Ser Arg Gln Met Ile Gln Gln Tyr Glu Met Val Tyr Arg Asp 
    210                 215                 220                 


Ala Gln Gly Asn Pro Leu Ser Gly Val Phe Lys Phe His Val Val Ile 
225                 230                 235                 240 


Xaa Xaa Phe Glu Met Ile Leu Ala Asp Cys Pro Glu Leu Lys Lys Ile 
                245                 250                 255     


His Trp Gly Arg Trp Lys Asp Ile Leu Xaa His Gly Arg Phe Lys Trp 
            260                 265                 270         


His Leu Asn Glu Lys Asp Met Glu Met Ile Cys Arg Ala Leu Leu Val 
        275                 280                 285             


Tyr Cys Val Lys His Tyr Lys Gly Asp Glu Lys Ile Lys Ser Phe Ile 
    290                 295                 300                 


Trp Glu Leu Ile Xaa Pro Xaa Lys Asp Gly Gln Ala Gln Xaa Leu Gln 
305                 310                 315                 320 


Asn His Ser Gly Leu Ser Ala Pro Val Pro Arg Gly Arg Lys Gly Lys 
                325                 330                 335     


Lys Xaa Lys Asn Gln Leu Leu Ile Pro Glu Leu Lys Asp Ala Asp Trp 
            340                 345                 350         


Leu Ala Xaa Cys Asn Pro Glu Val Val Leu His Asp Asp Gly Tyr Lys 
        355                 360                 365             


Lys His Leu Lys Gln His Cys Asn Lys Val Leu Leu Arg Val Arg Met 
    370                 375                 380                 


Leu Tyr Tyr Leu Lys Ala Glu Ile Leu Gly Glu Ala Ala Glu Lys Ala 
385                 390                 395                 400 


Phe Glu Gly Ser Pro Ala Arg Glu Leu Asp Val Pro Leu Pro Asp Ile 
                405                 410                 415     


Asp Tyr Met Glu Ile Pro Val Asp Trp Trp Asp Ala Glu Ala Asp Lys 
            420                 425                 430         


Ser Leu Leu Ile Gly Val Phe Lys His Gly Tyr Glu Arg Tyr Asn Ala 
        435                 440                 445             


Met Arg Ala Asp Pro Ala Leu Cys Phe Leu Glu Lys Val Gly Met Pro 
    450                 455                 460                 


Asp Glu Lys Ser Leu Ser Ala Glu Gln Gly Val Xaa Asp Gly Xaa Ser 
465                 470                 475                 480 


Asp Ile Pro Glu Arg Gln His Arg 
                485             


<210> 6004
<211> 149
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<400> 6004
Met Lys Met Lys Ile Gln Lys Lys Glu Lys Gln Leu Ser Asn Leu Lys 
1               5                   10                  15      


Val Leu Asn His Ser Pro Met Ser Asp Ala Ser Val Asn Phe Asp Tyr 
            20                  25                  30          


Lys Ser Pro Ser Pro Phe Asp Cys Ser Xaa Asp Gln Glu Glu Lys Ile 
        35                  40                  45              


Glu Asp Val Ala Ser His Cys Leu Pro Gln Lys Asp Leu Tyr Xaa Ala 
    50                  55                  60                  


Glu Glu Glu Ala Ala Xaa Leu Phe Pro Arg Lys Met Xaa Ser His Asn 
65                  70                  75                  80  


Gly Met Glu Asp Ser Gly Gly Gly Gly Xaa Gly Val Lys Lys Lys Arg 
                85                  90                  95      


Lys Lys Lys Glu Pro Gly Asp Gln Glu Gly Ala Ala Lys Gly Ser Lys 
            100                 105                 110         


Asp Arg Glu Pro Lys Pro Lys Arg Lys Arg Glu Pro Lys Glu Pro Lys 
        115                 120                 125             


Glu Pro Arg Lys Ala Lys Glu Pro Lys Lys Ala Lys Glu His Lys Glu 
    130                 135                 140                 


Pro Lys Gln Lys Asp 
145                 


<210> 6005
<211> 2715
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (873)..(873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1117)..(1117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1189)..(1189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1206)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1327)..(1327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1330)..(1330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1339)..(1339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1356)..(1356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1395)..(1395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1403)..(1403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1436)..(1436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1451)..(1451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1461)..(1461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1475)..(1475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1479)..(1479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1514)..(1514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1523)..(1524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1531)..(1531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1538)..(1538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1588)..(1588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1596)..(1596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1623)..(1623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1635)..(1635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1644)..(1644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1651)..(1651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1678)..(1678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1726)..(1726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1728)..(1728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1736)..(1736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1759)..(1759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1894)..(1894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1897)..(1898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1912)..(1912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1923)..(1923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1972)..(1972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1974)..(1974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1982)..(1982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2012)..(2012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2057)..(2057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2061)..(2061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2075)..(2075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2084)..(2084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2124)..(2124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2127)..(2127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2131)..(2131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2138)..(2138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2171)..(2171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2200)..(2200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2204)..(2204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2230)..(2230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2239)..(2239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2269)..(2269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2284)..(2284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2307)..(2307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2323)..(2323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2326)..(2327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2336)..(2336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2343)..(2343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2428)..(2428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2437)..(2437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2493)..(2493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2504)..(2504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2507)..(2507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2514)..(2514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2544)..(2545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2547)..(2547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2549)..(2549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2557)..(2558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2562)..(2562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2565)..(2565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2568)..(2568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2580)..(2580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2582)..(2582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2602)..(2603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2660)..(2660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2714)..(2714)
<223> Selenocysteine

<400> 6005
Met Lys Met Lys Ile Gln Lys Lys Glu Lys Gln Leu Ser Asn Leu Lys 
1               5                   10                  15      


Val Leu Asn His Ser Pro Met Ser Asp Ala Ser Val Asn Phe Asp Tyr 
            20                  25                  30          


Lys Ser Pro Ser Pro Phe Asp Cys Ser Xaa Asp Gln Glu Glu Lys Ile 
        35                  40                  45              


Glu Asp Val Ala Ser His Cys Leu Pro Gln Lys Asp Leu Tyr Xaa Ala 
    50                  55                  60                  


Glu Glu Glu Ala Ala Xaa Leu Phe Pro Arg Lys Met Xaa Ser His Asn 
65                  70                  75                  80  


Gly Met Glu Asp Ser Gly Gly Gly Gly Xaa Gly Val Lys Lys Lys Arg 
                85                  90                  95      


Lys Lys Lys Glu Pro Gly Asp Gln Glu Gly Ala Ala Lys Gly Ser Lys 
            100                 105                 110         


Asp Arg Glu Pro Lys Pro Lys Arg Lys Arg Glu Pro Lys Glu Pro Lys 
        115                 120                 125             


Glu Pro Arg Lys Ala Lys Glu Pro Lys Lys Ala Lys Glu His Lys Glu 
    130                 135                 140                 


Pro Lys Gln Lys Asp Gly Ala Lys Lys Ala Arg Lys Pro Arg Glu Ala 
145                 150                 155                 160 


Ser Gly Xaa Lys Glu Ala Lys Glu Lys Arg Ser Cys Xaa Asp Ser Ala 
                165                 170                 175     


Ala Arg Xaa Lys Ser Arg Lys Ala Ser Lys Glu Gln Gly Pro Xaa Pro 
            180                 185                 190         


Val Glu Lys Lys Lys Lys Gly Lys Arg Lys Ser Glu Xaa Xaa Val Glu 
        195                 200                 205             


Ser Leu Glu Leu Asp Gln Gly Leu Xaa Asn Pro Ser Leu Arg Ser Pro 
    210                 215                 220                 


Glu Glu Ser Xaa Glu Ser Xaa Asp Ser Gln Lys Arg Arg Ser Gly Arg 
225                 230                 235                 240 


Gln Val Lys Arg Arg Lys Tyr Asn Glu Asp Leu Asp Phe Lys Val Val 
                245                 250                 255     


Asp Asp Asp Gly Glu Xaa Ile Ala Val Leu Gly Ala Gly Arg Xaa Ser 
            260                 265                 270         


Ala Leu Ser Ala Ser Xaa Leu Ala Trp Gln Ala Glu Glu Pro Pro Glu 
        275                 280                 285             


Asp Asp Ala Asn Ile Ile Glu Lys Ile Leu Ala Ser Lys Xaa Val Gln 
    290                 295                 300                 


Glu Val His Pro Gly Glu Pro Pro Phe Asp Leu Glu Leu Phe Tyr Val 
305                 310                 315                 320 


Lys Tyr Arg Asn Phe Ser Tyr Leu His Cys Lys Trp Ala Xaa Met Glu 
                325                 330                 335     


Glu Leu Glu Lys Asp Pro Arg Ile Ala Gln Lys Ile Lys Arg Phe Arg 
            340                 345                 350         


Asn Lys Gln Ala Gln Met Lys His Ile Phe Xaa Glu Pro Asp Glu Asp 
        355                 360                 365             


Leu Phe Asn Pro Asp Tyr Val Glu Val Asp Arg Ile Leu Glu Val Ala 
    370                 375                 380                 


His Xaa Lys Asp Ala Glu Xaa Gly Glu Glu Val Xaa His Tyr Leu Val 
385                 390                 395                 400 


Lys Trp Cys Ser Leu Pro Tyr Glu Glu Ser Xaa Trp Glu Leu Glu Glu 
                405                 410                 415     


Asp Val Asp Pro Ala Lys Val Lys Glu Phe Glu Ser Leu Gln Val Leu 
            420                 425                 430         


Pro Glu Ile Lys His Val Glu Arg Pro Ala Ser Asp Ser Trp Gln Lys 
        435                 440                 445             


Leu Glu Lys Ser Arg Glu Tyr Lys Asn Ser Asn Gln Leu Arg Glu Tyr 
    450                 455                 460                 


Gln Leu Glu Gly Met Asn Trp Leu Leu Phe Asn Trp Tyr Asn Arg Lys 
465                 470                 475                 480 


Asn Cys Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Xaa Ile Gln Ser 
                485                 490                 495     


Ile Xaa Phe Leu Ser Glu Ile Phe Leu Arg Gly Ile His Gly Pro Phe 
            500                 505                 510         


Leu Ile Ile Ala Pro Leu Ser Xaa Ile Xaa Asn Trp Glu Arg Glu Phe 
        515                 520                 525             


Arg Xaa Trp Xaa Glu Met Asn Ala Ile Val Tyr His Gly Ser Gln Ile 
    530                 535                 540                 


Ser Arg Gln Met Ile Gln Gln Tyr Glu Met Val Tyr Arg Asp Ala Gln 
545                 550                 555                 560 


Gly Asn Pro Leu Ser Gly Val Phe Lys Phe His Val Val Ile Xaa Xaa 
                565                 570                 575     


Phe Glu Met Ile Leu Ala Asp Cys Pro Glu Leu Lys Lys Ile His Trp 
            580                 585                 590         


Ser Cys Val Ile Ile Asp Glu Ala His Arg Leu Lys Asn Arg Asn Cys 
        595                 600                 605             


Lys Leu Leu Glu Gly Leu Lys Leu Met Ala Leu Glu His Lys Val Leu 
    610                 615                 620                 


Leu Xaa Gly Xaa Pro Leu Gln Asn Ser Val Glu Glu Leu Phe Ser Leu 
625                 630                 635                 640 


Leu Asn Phe Leu Glu Pro Ser Gln Phe Pro Ser Glu Xaa Ala Phe Leu 
                645                 650                 655     


Glu Glu Phe Gly Asp Leu Lys Xaa Glu Glu Gln Val Lys Lys Leu Gln 
            660                 665                 670         


Ser Ile Leu Lys Pro Met Met Leu Arg Arg Leu Lys Asp Asp Val Glu 
        675                 680                 685             


Lys Asn Leu Ala Pro Lys Gln Glu Xaa Ile Ile Glu Val Glu Leu Xaa 
    690                 695                 700                 


Asn Ile Gln Lys Lys Tyr Tyr Arg Ala Ile Leu Glu Lys Asn Phe Ser 
705                 710                 715                 720 


Phe Leu Xaa Lys Gly Ala Asn Gln His Asn Met Pro Asn Leu Ile Asn 
                725                 730                 735     


Xaa Met Met Glu Leu Arg Lys Cys Cys Asn His Pro Tyr Leu Ile Asn 
            740                 745                 750         


Gly Ala Glu Glu Lys Ile Leu Glu Asp Phe Arg Lys Xaa His Ser Pro 
        755                 760                 765             


Asp Ala Pro Asp Phe Gln Leu Gln Ala Met Ile Gln Ala Ala Gly Lys 
    770                 775                 780                 


Leu Val Leu Ile Asp Lys Leu Leu Pro Lys Leu Ile Ala Gly Gly His 
785                 790                 795                 800 


Lys Val Leu Ile Phe Ser Gln Met Val Arg Cys Leu Asp Ile Leu Glu 
                805                 810                 815     


Asp Tyr Leu Ile Gln Arg Arg Tyr Xaa Tyr Glu Arg Ile Asp Gly Arg 
            820                 825                 830         


Val Arg Gly Asn Leu Arg Gln Ala Ala Ile Asp Arg Phe Cys Lys Pro 
        835                 840                 845             


Asp Ser Asp Arg Phe Val Phe Leu Leu Cys Xaa Arg Ala Gly Gly Leu 
    850                 855                 860                 


Gly Ile Asn Leu Xaa Ala Ala Asp Xaa Cys Ile Ile Phe Asp Ser Asp 
865                 870                 875                 880 


Trp Asn Pro Gln Asn Asp Leu Gln Ala Gln Ala Arg Cys His Arg Ile 
                885                 890                 895     


Gly Gln Ser Lys Ala Val Lys Val Tyr Arg Leu Ile Xaa Arg Asn Ser 
            900                 905                 910         


Tyr Glu Arg Glu Met Phe Asp Lys Ala Ser Leu Lys Leu Gly Leu Asp 
        915                 920                 925             


Lys Ala Val Leu Gln Asp Ile Asn Arg Lys Gly Gly Xaa Asn Gly Val 
    930                 935                 940                 


Gln Gln Leu Ser Lys Met Glu Val Glu Asp Leu Leu Arg Lys Gly Ala 
945                 950                 955                 960 


Tyr Gly Ala Leu Met Asp Glu Glu Asp Glu Gly Ser Lys Phe Cys Glu 
                965                 970                 975     


Glu Asp Ile Asp Gln Ile Leu Gln Arg Arg Xaa His Xaa Ile Xaa Ile 
            980                 985                 990         


Gln Ser Glu Gly Lys Gly Ser Xaa  Phe Ala Lys Ala Ser  Phe Val Ala 
        995                 1000                 1005             


Ser Gly  Asn Arg Xaa Asp Ile  Ser Leu Asp Asp Pro  Asn Phe Trp 
    1010                 1015                 1020             


Gln Lys  Trp Ala Lys Ile Ala  Glu Leu Asp Xaa Glu  Ala Lys Asn 
    1025                 1030                 1035             


Glu Lys  Glu Ser Leu Val Ile  Asp Arg Pro Arg Val  Arg Lys Gln 
    1040                 1045                 1050             


Xaa Lys  His Tyr Asn Ser Phe  Glu Glu Asp Glu Leu  Met Glu Phe 
    1055                 1060                 1065             


Ser Glu  Leu Asp Ser Asp Ser  Asp Glu Arg Pro Xaa  Arg Ser Arg 
    1070                 1075                 1080             


Arg Leu  Asn Asp Lys Ala Arg  Arg Tyr Leu Arg Ala  Glu Cys Phe 
    1085                 1090                 1095             


Arg Val  Glu Lys Asn Leu Leu  Ile Phe Gly Trp Gly  Arg Trp Lys 
    1100                 1105                 1110             


Asp Ile  Leu Xaa His Gly Arg  Phe Lys Trp His Leu  Asn Glu Lys 
    1115                 1120                 1125             


Asp Met  Glu Met Ile Cys Arg  Ala Leu Leu Val Tyr  Cys Val Lys 
    1130                 1135                 1140             


His Tyr  Lys Gly Asp Glu Lys  Ile Lys Ser Phe Ile  Trp Glu Leu 
    1145                 1150                 1155             


Ile Xaa  Pro Xaa Lys Asp Gly  Gln Ala Gln Xaa Leu  Gln Asn His 
    1160                 1165                 1170             


Ser Gly  Leu Ser Ala Pro Val  Pro Arg Gly Arg Lys  Gly Lys Lys 
    1175                 1180                 1185             


Xaa Lys  Asn Gln Leu Leu Ile  Pro Glu Leu Lys Asp  Ala Asp Trp 
    1190                 1195                 1200             


Leu Ala  Xaa Cys Asn Pro Glu  Val Val Leu His Asp  Asp Gly Tyr 
    1205                 1210                 1215             


Lys Lys  His Leu Lys Gln His  Cys Asn Lys Val Leu  Leu Arg Val 
    1220                 1225                 1230             


Arg Met  Leu Tyr Tyr Leu Lys  Ala Glu Ile Leu Gly  Glu Ala Ala 
    1235                 1240                 1245             


Glu Lys  Ala Phe Glu Gly Ser  Pro Ala Arg Glu Leu  Asp Val Pro 
    1250                 1255                 1260             


Leu Pro  Asp Ile Asp Tyr Met  Glu Ile Pro Val Asp  Trp Trp Asp 
    1265                 1270                 1275             


Ala Glu  Ala Asp Lys Ser Leu  Leu Ile Gly Val Phe  Lys His Gly 
    1280                 1285                 1290             


Tyr Glu  Arg Tyr Asn Ala Met  Arg Ala Asp Pro Ala  Leu Cys Phe 
    1295                 1300                 1305             


Leu Glu  Lys Val Gly Met Pro  Asp Glu Lys Ser Leu  Ser Ala Glu 
    1310                 1315                 1320             


Gln Gly  Val Xaa Asp Gly Xaa  Ser Asp Ile Pro Glu  Arg Gly Asn 
    1325                 1330                 1335             


Xaa Asp  Lys Glu Asp Asn Ala  Glu Asp Lys Val Asp  Gly Leu Gln 
    1340                 1345                 1350             


Lys Gln  Xaa Glu Ser Ser Ser  Asp Gly Gly Asp Gly  Val Phe Ser 
    1355                 1360                 1365             


Glu Lys  Lys Asp Asp Ser Arg  Ala Ala Gln Asp Gly  Ser Asp Pro 
    1370                 1375                 1380             


Asp Lys  Ser Pro Trp Pro Val  Ser Ser Ala Leu Xaa  Ala Arg Leu 
    1385                 1390                 1395             


Arg Arg  Leu Val Xaa Val Tyr  Gln Arg Cys Asn Arg  Lys Glu Leu 
    1400                 1405                 1410             


Cys Arg  Pro Glu Ile Leu Gly  Pro Gly Asn Gln Gly  Tyr Trp Val 
    1415                 1420                 1425             


Gln Glu  Glu Met Phe Arg Arg  Xaa Ser Glu Met Asp  Leu Ile Asn 
    1430                 1435                 1440             


Lys Glu  Ala Gln Lys Arg Trp  Xaa Arg Arg Glu Gln  Ala Asp Phe 
    1445                 1450                 1455             


Tyr Arg  Xaa Val Ser Ser Phe  Gly Val Val Tyr Asp  Gln Glu Lys 
    1460                 1465                 1470             


Lys Xaa  Phe Asp Trp Xaa Gln  Phe Arg Ile Ile Ser  Arg Leu Asp 
    1475                 1480                 1485             


Lys Lys  Ser Asp Glu Ser Leu  Glu Gln Tyr Phe Tyr  Ser Phe Val 
    1490                 1495                 1500             


Ala Met  Cys Arg Asn Val Cys  Arg Leu Pro Xaa Trp  Lys Asp Gly 
    1505                 1510                 1515             


Gly Pro  Pro Asp Xaa Xaa Ile  Tyr Val Glu Pro Ile  Xaa Glu Glu 
    1520                 1525                 1530             


Arg Ala  Ala Arg Xaa Leu Tyr  Arg Ile Glu Leu Leu  Arg Lys Val 
    1535                 1540                 1545             


Arg Glu  Gln Val Leu Lys Cys  Pro Gln Leu His Glu  Arg Leu Gln 
    1550                 1555                 1560             


Leu Cys  Arg Pro Ser Leu Tyr  Leu Pro Val Trp Trp  Glu Cys Gly 
    1565                 1570                 1575             


Lys His  Asp Arg Asp Leu Leu  Ile Gly Xaa Ala Lys  His Gly Leu 
    1580                 1585                 1590             


Asn Arg  Xaa Asp Cys Tyr Ile  Met Asn Asp Pro Gln  Leu Ser Phe 
    1595                 1600                 1605             


Leu Asp  Ala Tyr Arg Asn Tyr  Ala Gln His Lys Arg  Ser Gly Xaa 
    1610                 1615                 1620             


Gln Ala  Pro Gly Asn Leu Cys  Cys Leu Tyr Gln Xaa  Asn Ser Lys 
    1625                 1630                 1635             


Leu Tyr  Glu Ser Leu Xaa Tyr  Ser Gln Met Ser Arg  Xaa Ser Glu 
    1640                 1645                 1650             


Ser Leu  Glu Asn Glu Pro Glu  Asn Leu Val Arg Val  Glu Ser Arg 
    1655                 1660                 1665             


Asp Asp  His Leu Ser Leu Pro  Asp Val Xaa Cys Glu  Asn Phe Ile 
    1670                 1675                 1680             


Ser Lys  Val Gln Asp Val Ile  Ser Ile Asn His Asp  Glu Ser Leu 
    1685                 1690                 1695             


Leu Pro  Glu Ser Leu Glu Ser  Met Met Tyr Gly Lys  Lys Val Leu 
    1700                 1705                 1710             


Ser Gln  Glu Pro Ser Ser Phe  Gln Glu Ser Pro Ser  Xaa Asn Xaa 
    1715                 1720                 1725             


Glu Ser  Arg Lys Asp Val Ile  Xaa Ile Ser Ile Ser  Lys Asp Gly 
    1730                 1735                 1740             


Asn Cys  Gln Ser Gly Gly Pro  Glu Ala Glu Ile Ala  Ser Gly Pro 
    1745                 1750                 1755             


Xaa Phe  Met Gly Ser Leu Glu  Ala Gly Gly Val Ala  Gln Ala Asn 
    1760                 1765                 1770             


Ile Lys  Asn Gly Lys His Leu  Leu Met Ser Ile Ser  Lys Glu Gly 
    1775                 1780                 1785             


Glu Leu  Cys Cys Ser Glu Ala  Gly Gln Arg Pro Glu  Asn Ile Gly 
    1790                 1795                 1800             


Gln Leu  Glu Ala Lys Cys Leu  Ala Ser Pro Ser Leu  Asn Pro Gly 
    1805                 1810                 1815             


Asn Glu  Ser Gly Phe Val Asp  Met Cys Ser Leu Ser  Val Cys Asp 
    1820                 1825                 1830             


Ser Lys  Arg Asn Leu Ser Ser  Asp Gln Gln Leu Ile  Asp Leu Leu 
    1835                 1840                 1845             


Glu Asn  Lys Ser Leu Glu Ser  Lys Leu Ile Leu Ser  Gln Asn His 
    1850                 1855                 1860             


Ser Asp  Glu Glu Glu Glu Glu  Glu Glu Asn Glu Glu  Glu Asn Leu 
    1865                 1870                 1875             


Ala Met  Ala Val Gly Met Gly  Glu Arg Pro Glu Val  Leu His Leu 
    1880                 1885                 1890             


Xaa Glu  Pro Xaa Xaa Asn Ile  Ser Arg Glu Lys Asn  Gln Gly Phe 
    1895                 1900                 1905             


Gln Asp  Glu Xaa Lys Lys Gly  Ser Leu Glu Val Ala  Asn Gln Xaa 
    1910                 1915                 1920             


Pro Gly  Leu Gln Arg Ala Phe  Pro Ala Pro Ala Ala  Cys Gln Cys 
    1925                 1930                 1935             


His Cys  Lys His Met Glu Arg  Trp Met His Gly Leu  Glu Asn Asp 
    1940                 1945                 1950             


Glu Phe  Glu Ile Glu Lys Pro  Lys Ala Tyr Ile Pro  Asp Leu Phe 
    1955                 1960                 1965             


Lys Ser  Lys Xaa Asn Xaa Ile  Ala Met Glu Gly Glu  Pro Xaa Ala 
    1970                 1975                 1980             


Ile Pro  Ser Gln Pro Phe Lys  Val Lys His Glu Leu  Leu Lys Glu 
    1985                 1990                 1995             


Pro Trp  Lys Glu Ser Ala Glu  Gly Gln Asn Val Phe  Pro Xaa Tyr 
    2000                 2005                 2010             


Pro Leu  Glu Gly Ser Glu Leu  Lys Ser Glu Asp Met  Asp Phe Glu 
    2015                 2020                 2025             


Asn Lys  Asp Asp Tyr Asp Arg  Asp Gly Asn Cys His  Ser Gln Asp 
    2030                 2035                 2040             


Tyr Pro  Gly Lys Tyr Ser Glu  Glu Glu Ser Lys Ser  Ser Xaa Ser 
    2045                 2050                 2055             


Gly Ile  Xaa Gly Asp Ile Gly  Asp Glu Leu Gln Glu  Ala Arg Ala 
    2060                 2065                 2070             


Pro Xaa  Ile Ala Gln Leu Leu  Gln Glu Lys Xaa Leu  Tyr Ser Phe 
    2075                 2080                 2085             


Ser Glu  Trp Pro Lys Asp Arg  Val Ile Ile Asn Arg  Leu Asp Asn 
    2090                 2095                 2100             


Ile Cys  His Val Val Leu Lys  Gly Lys Trp Pro Ser  Ser Gln Gln 
    2105                 2110                 2115             


Tyr Glu  Pro Ser Gly Xaa Leu  Pro Xaa Pro Val Leu  Xaa Ser Ser 
    2120                 2125                 2130             


Ala Gly  Ser Arg Xaa Ser Leu  Ser Glu Pro Glu Ala  Ala Glu His 
    2135                 2140                 2145             


Ser Phe  Ser Asn Gly Ala Ala  Leu Ala Ala Gln Ile  His Lys Glu 
    2150                 2155                 2160             


Ser Phe  Leu Ala Pro Val Phe  Xaa Lys Asp Glu Gln  Lys His Arg 
    2165                 2170                 2175             


Arg Pro  Tyr Glu Phe Glu Val  Glu Arg Asp Ala Lys  Ala Arg Gly 
    2180                 2185                 2190             


Leu Glu  Gln Phe Ser Ala Xaa  His Gly His Xaa Pro  Ile Ile Leu 
    2195                 2200                 2205             


Asn Gly  Trp His Gly Glu Ser  Ala Met Asp Leu Ser  Cys Ser Ser 
    2210                 2215                 2220             


Glu Gly  Ser Pro Gly Ala Xaa  Ser Pro Phe Pro Val  Ser Ala Ser 
    2225                 2230                 2235             


Xaa Pro  Lys Ile Gly Ala Ile  Ser Ser Leu Gln Gly  Ala Leu Gly 
    2240                 2245                 2250             


Met Asp  Leu Ser Gly Ile Leu  Gln Ala Gly Leu Ile  His Pro Val 
    2255                 2260                 2265             


Xaa Gly  Gln Ile Val Asn Gly  Ser Leu Arg Arg Asp  Asp Ala Ala 
    2270                 2275                 2280             


Xaa Arg  Arg Arg Arg Gly Arg  Arg Lys His Val Glu  Gly Gly Met 
    2285                 2290                 2295             


Asp Leu  Ile Phe Leu Lys Glu  Gln Xaa Leu Gln Ala  Gly Ile Leu 
    2300                 2305                 2310             


Glu Val  His Glu Asp Pro Gly  Gln Ala Xaa Leu Ser  Xaa Xaa His 
    2315                 2320                 2325             


Pro Glu  Gly Pro Gly Pro Ala  Xaa Ser Ala Pro Glu  Pro Ala Xaa 
    2330                 2335                 2340             


Ala Ala  Ser Ser Gln Ala Glu  Lys Ser Ile Pro Ser  Lys Ser Leu 
    2345                 2350                 2355             


Leu Asp  Trp Leu Arg Gln Gln  Ala Asp Tyr Ser Leu  Glu Val Pro 
    2360                 2365                 2370             


Gly Phe  Gly Ala Asn Phe Ser  Asp Lys Pro Lys Gln  Arg Arg Pro 
    2375                 2380                 2385             


Arg Cys  Lys Glu Pro Gly Lys  Leu Asp Val Ser Ser  Leu Ser Gly 
    2390                 2395                 2400             


Glu Glu  Arg Val Pro Ala Ile  Pro Lys Glu Pro Gly  Leu Arg Gly 
    2405                 2410                 2415             


Phe Leu  Pro Glu Asn Lys Phe  Asn His Xaa Leu Ala  Glu Pro Ile 
    2420                 2425                 2430             


Leu Arg  Asp Xaa Gly Pro Arg  Arg Arg Gly Arg Arg  Pro Arg Ser 
    2435                 2440                 2445             


Glu Leu  Leu Lys Ala Pro Ser  Ile Val Ala Asp Ser  Pro Ser Gly 
    2450                 2455                 2460             


Met Gly  Pro Leu Phe Met Asn  Gly Leu Ile Ala Gly  Met Asp Leu 
    2465                 2470                 2475             


Val Gly  Leu Gln Asn Met Arg  Asn Met Pro Gly Ile  Pro Leu Xaa 
    2480                 2485                 2490             


Gly Leu  Val Gly Phe Pro Ala  Gly Phe Ala Xaa Met  Pro Xaa Gly 
    2495                 2500                 2505             


Glu Glu  Val Lys Ser Xaa Leu  Ser Met Leu Pro Met  Met Leu Pro 
    2510                 2515                 2520             


Gly Met  Ala Ala Val Pro Gln  Met Phe Gly Val Gly  Gly Leu Leu 
    2525                 2530                 2535             


Ser Pro  Pro Met Ala Xaa Xaa  Cys Xaa Ser Xaa Ala  Pro Ala Ser 
    2540                 2545                 2550             


Leu Ser  Ser Xaa Xaa Lys Ser  Gly Xaa Ala Val Xaa  Glu Lys Xaa 
    2555                 2560                 2565             


Ala Glu  Asp Lys Pro Ser Ser  His Asp Val Lys Xaa  Asp Xaa Leu 
    2570                 2575                 2580             


Ala Glu  Asp Lys Pro Gly Pro  Gly Pro Phe Ser Asp  Gln Ser Glu 
    2585                 2590                 2595             


Pro Ala  Ile Xaa Xaa Ser Ser  Pro Val Ala Phe Asn  Pro Phe Leu 
    2600                 2605                 2610             


Ile Pro  Gly Val Ser Pro Gly  Leu Ile Tyr Pro Ser  Met Phe Leu 
    2615                 2620                 2625             


Ser Pro  Gly Met Gly Met Ala  Leu Pro Ala Met Gln  Gln Ala Arg 
    2630                 2635                 2640             


His Ser  Glu Ile Val Gly Leu  Glu Ser Gln Lys Arg  Lys Lys Lys 
    2645                 2650                 2655             


Lys Xaa  Lys Gly Asp Asn Pro  Asn Ser His Pro Glu  Pro Ala Pro 
    2660                 2665                 2670             


Ser Cys  Glu Arg Glu Pro Ser  Gly Asp Glu Asn Cys  Ala Glu Pro 
    2675                 2680                 2685             


Ser Ala  Pro Leu Pro Ala Glu  Arg Glu His Gly Ala  Gln Ala Gly 
    2690                 2695                 2700             


Glu Gly  Ala Leu Lys Asp Ser  Asn Asn Asp Xaa Asn  
    2705                 2710                 2715 


<210> 6006
<211> 525
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<400> 6006
Xaa Ala Ser Lys Xaa Val Gln Glu Val His Pro Gly Glu Pro Pro Phe 
1               5                   10                  15      


Asp Leu Glu Leu Phe Tyr Val Lys Tyr Arg Asn Phe Ser Tyr Leu His 
            20                  25                  30          


Cys Lys Trp Ala Xaa Met Glu Glu Leu Glu Lys Asp Pro Arg Ile Ala 
        35                  40                  45              


Gln Lys Ile Lys Arg Phe Arg Asn Lys Gln Ala Gln Met Lys His Ile 
    50                  55                  60                  


Phe Xaa Glu Pro Asp Glu Asp Leu Phe Asn Pro Asp Tyr Val Glu Val 
65                  70                  75                  80  


Asp Arg Ile Leu Glu Val Ala His Xaa Lys Asp Ala Glu Xaa Gly Glu 
                85                  90                  95      


Glu Val Xaa His Tyr Leu Val Lys Trp Cys Ser Leu Pro Tyr Glu Glu 
            100                 105                 110         


Ser Xaa Trp Glu Leu Glu Glu Asp Val Asp Pro Ala Lys Val Lys Glu 
        115                 120                 125             


Phe Glu Ser Leu Gln Val Leu Pro Glu Ile Lys His Val Glu Arg Pro 
    130                 135                 140                 


Ala Ser Asp Ser Trp Gln Lys Leu Glu Lys Ser Arg Glu Tyr Lys Asn 
145                 150                 155                 160 


Ser Asn Gln Leu Arg Glu Tyr Gln Leu Glu Gly Met Asn Trp Leu Leu 
                165                 170                 175     


Phe Asn Trp Tyr Asn Arg Lys Asn Cys Ile Leu Ala Asp Glu Met Gly 
            180                 185                 190         


Leu Gly Lys Xaa Ile Gln Ser Ile Xaa Phe Leu Ser Glu Ile Phe Leu 
        195                 200                 205             


Arg Gly Ile His Gly Pro Phe Leu Ile Ile Ala Pro Leu Ser Xaa Ile 
    210                 215                 220                 


Xaa Asn Trp Glu Arg Glu Phe Arg Xaa Trp Xaa Glu Met Asn Ala Ile 
225                 230                 235                 240 


Val Tyr His Gly Ser Gln Ile Ser Arg Gln Met Ile Gln Gln Tyr Glu 
                245                 250                 255     


Met Val Tyr Arg Asp Ala Gln Gly Asn Pro Leu Ser Gly Val Phe Lys 
            260                 265                 270         


Phe His Val Val Ile Xaa Xaa Phe Glu Met Ile Leu Ala Asp Cys Pro 
        275                 280                 285             


Glu Leu Lys Lys Ile His Trp Gly Arg Trp Lys Asp Ile Leu Xaa His 
    290                 295                 300                 


Gly Arg Phe Lys Trp His Leu Asn Glu Lys Asp Met Glu Met Ile Cys 
305                 310                 315                 320 


Arg Ala Leu Leu Val Tyr Cys Val Lys His Tyr Lys Gly Asp Glu Lys 
                325                 330                 335     


Ile Lys Ser Phe Ile Trp Glu Leu Ile Xaa Pro Xaa Lys Asp Gly Gln 
            340                 345                 350         


Ala Gln Xaa Leu Gln Asn His Ser Gly Leu Ser Ala Pro Val Pro Arg 
        355                 360                 365             


Gly Arg Lys Gly Lys Lys Xaa Lys Asn Gln Leu Leu Ile Pro Glu Leu 
    370                 375                 380                 


Lys Asp Ala Asp Trp Leu Ala Xaa Cys Asn Pro Glu Val Val Leu His 
385                 390                 395                 400 


Asp Asp Gly Tyr Lys Lys His Leu Lys Gln His Cys Asn Lys Val Leu 
                405                 410                 415     


Leu Arg Val Arg Met Leu Tyr Tyr Leu Lys Ala Glu Ile Leu Gly Glu 
            420                 425                 430         


Ala Ala Glu Lys Ala Phe Glu Gly Ser Pro Ala Arg Glu Leu Asp Val 
        435                 440                 445             


Pro Leu Pro Asp Ile Asp Tyr Met Glu Ile Pro Val Asp Trp Trp Asp 
    450                 455                 460                 


Ala Glu Ala Asp Lys Ser Leu Leu Ile Gly Val Phe Lys His Gly Tyr 
465                 470                 475                 480 


Glu Arg Tyr Asn Ala Met Arg Ala Asp Pro Ala Leu Cys Phe Leu Glu 
                485                 490                 495     


Lys Val Gly Met Pro Asp Glu Lys Ser Leu Ser Ala Glu Gln Gly Val 
            500                 505                 510         


Xaa Asp Gly Xaa Ser Asp Ile Pro Glu Arg Gln His Arg 
        515                 520                 525 


<210> 6007
<211> 39
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<400> 6007
His Gln Pro Trp Ala Gln Leu His Pro Ser Pro Gln Asn Xaa Pro Gln 
1               5                   10                  15      


Lys Val Pro Val His Gln His Ser Pro Ser Glu Pro Phe Leu Glu Lys 
            20                  25                  30          


Pro Val Pro Asp Met Xaa Gln 
        35                  


<210> 6008
<211> 33
<212> PRT
<213> Homo sapiens

<400> 6008
Met Ala Asp Pro Gly Met Met Ser Leu Phe Gly Glu Asp Gly Asn Ile 
1               5                   10                  15      


Phe Ser Glu Gly Leu Glu Gly Leu Gly Glu Cys Gly Tyr Pro Glu Asn 
            20                  25                  30          


Pro 
    


<210> 6009
<211> 948
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<400> 6009
Met Ala Asp Pro Gly Met Met Ser Leu Phe Gly Glu Asp Gly Asn Ile 
1               5                   10                  15      


Phe Ser Glu Gly Leu Glu Gly Leu Gly Glu Cys Gly Tyr Pro Glu Asn 
            20                  25                  30          


Pro Val Asn Pro Met Gly Gln Gln Met Pro Ile Asp Gln Gly Phe Ala 
        35                  40                  45              


Ser Leu Gln Pro Ser Leu His His Pro Ser Xaa Asn Gln Asn Gln Xaa 
    50                  55                  60                  


Lys Leu Xaa His Phe Asp His Tyr Asn Gln Tyr Glu Gln Gln Lys Met 
65                  70                  75                  80  


His Leu Met Asp Gln Pro Asn Arg Met Met Ser Asn Xaa Pro Gly Asn 
                85                  90                  95      


Gly Leu Ala Ser Pro His Ser Gln Tyr His Xaa Pro Pro Val Pro Gln 
            100                 105                 110         


Val Pro His Gly Gly Ser Gly Gly Gly Gln Met Gly Val Tyr Pro Gly 
        115                 120                 125             


Met Gln Asn Glu Arg His Gly Gln Ser Phe Val Asp Ser Ser Ser Met 
    130                 135                 140                 


Trp Gly Pro Arg Ala Val Gln Val Pro Asp Gln Ile Arg Ala Pro Tyr 
145                 150                 155                 160 


Gln Gln Gln Gln Pro Gln Pro Gln Pro Pro Gln Pro Ala Pro Ser Gly 
                165                 170                 175     


Pro Pro Ala Gln Gly His Pro Gln His Met Gln Gln Met Gly Ser Tyr 
            180                 185                 190         


Met Ala Arg Gly Asp Phe Ser Met Gln Gln His Gly Gln Pro Gln Gln 
        195                 200                 205             


Arg Met Ser Gln Phe Ser Gln Gly Gln Glu Gly Leu Asn Gln Gly Asn 
    210                 215                 220                 


Pro Phe Ile Ala Xaa Ser Gly Pro Gly His Leu Ser His Val Pro Gln 
225                 230                 235                 240 


Gln Ser Pro Ser Met Ala Pro Ser Leu Arg His Ser Val Gln Gln Phe 
                245                 250                 255     


His His His Pro Ser Xaa Ala Leu His Gly Glu Ser Val Ala His Ser 
            260                 265                 270         


Pro Arg Phe Ser Pro Asn Pro Pro Gln Gln Gly Ala Val Arg Pro Gln 
        275                 280                 285             


Xaa Leu Asn Phe Ser Ser Arg Ser Gln Xaa Val Pro Ser Pro Xaa Ile 
    290                 295                 300                 


Asn Asn Ser Gly Gln Tyr Ser Arg Tyr Pro Tyr Ser Asn Leu Asn Gln 
305                 310                 315                 320 


Gly Leu Val Asn Asn Xaa Gly Met Asn Gln Asn Leu Gly Leu Xaa Asn 
                325                 330                 335     


Asn Xaa Pro Met Asn Gln Ser Val Pro Arg Tyr Pro Asn Ala Val Gly 
            340                 345                 350         


Phe Pro Ser Asn Ser Gly Gln Gly Leu Met His Gln Gln Pro Ile His 
        355                 360                 365             


Pro Ser Gly Ser Leu Asn Gln Met Asn Xaa Gln Xaa Met His Pro Ser 
    370                 375                 380                 


Gln Pro Gln Gly Xaa Tyr Ala Ser Pro Pro Pro Met Ser Pro Met Lys 
385                 390                 395                 400 


Ala Met Ser Asn Pro Ala Gly Xaa Pro Pro Pro Gln Val Arg Pro Gly 
                405                 410                 415     


Ser Ala Gly Ile Pro Met Glu Val Gly Ser Tyr Pro Asn Met Pro His 
            420                 425                 430         


Pro Gln Pro Ser His Gln Pro Pro Gly Ala Met Gly Ile Gly Gln Arg 
        435                 440                 445             


Asn Met Gly Pro Arg Asn Met Gln Gln Ser Arg Pro Phe Ile Gly Met 
    450                 455                 460                 


Ser Ser Ala Pro Arg Glu Leu Xaa Gly His Met Arg Pro Asn Gly Cys 
465                 470                 475                 480 


Pro Gly Val Gly Leu Gly Asp Pro Gln Ala Ile Gln Glu Arg Leu Ile 
                485                 490                 495     


Pro Gly Gln Gln His Pro Gly Gln Gln Pro Ser Phe Gln Gln Leu Pro 
            500                 505                 510         


Xaa Cys Pro Pro Leu Gln Pro His Pro Gly Leu His His Gln Ser Ser 
        515                 520                 525             


Pro Pro His Pro His His Gln Pro Trp Ala Gln Leu His Pro Ser Pro 
    530                 535                 540                 


Gln Asn Xaa Pro Gln Lys Val Pro Val His Gln His Ser Pro Ser Glu 
545                 550                 555                 560 


Pro Phe Leu Glu Lys Pro Val Pro Asp Met Xaa Gln Lys Pro Lys Gln 
                565                 570                 575     


Lys Arg His Arg Cys Arg Asn Pro Asn Lys Leu Asp Ile Asn Xaa Leu 
            580                 585                 590         


Xaa Gly Glu Glu Arg Val Pro Val Val Asn Lys Arg Asn Gly Lys Lys 
        595                 600                 605             


Met Gly Gly Ala Met Ala Pro Pro Met Lys Asp Leu Pro Arg Trp Leu 
    610                 615                 620                 


Glu Glu Asn Pro Glu Phe Ala Val Ala Pro Asp Trp Xaa Asp Ile Val 
625                 630                 635                 640 


Lys Gln Ser Gly Phe Val Pro Glu Ser Met Phe Asp Arg Leu Leu Xaa 
                645                 650                 655     


Gly Pro Val Val Arg Gly Glu Gly Ala Ser Arg Arg Gly Arg Arg Pro 
            660                 665                 670         


Lys Ser Glu Ile Ala Arg Ala Ala Ala Ala Ala Ala Ala Val Ala Ser 
        675                 680                 685             


Xaa Ser Gly Ile Asn Pro Leu Leu Val Asn Ser Leu Phe Ala Gly Met 
    690                 695                 700                 


Asp Leu Xaa Ser Leu Gln Asn Leu Gln Asn Leu Gln Ser Leu Gln Leu 
705                 710                 715                 720 


Ala Gly Leu Met Gly Phe Pro Pro Gly Leu Ala Xaa Ala Ala Xaa Ala 
                725                 730                 735     


Gly Gly Asp Ala Lys Asn Pro Ala Ala Val Leu Pro Leu Met Leu Pro 
            740                 745                 750         


Gly Met Ala Gly Leu Pro Asn Val Phe Gly Leu Gly Gly Leu Leu Asn 
        755                 760                 765             


Asn Pro Leu Ser Ala Ala Xaa Gly Asn Xaa Xaa Xaa Ala Ser Ser Gln 
    770                 775                 780                 


Gly Glu Pro Glu Asp Ser Xaa Ser Lys Gly Glu Glu Lys Gly Asn Glu 
785                 790                 795                 800 


Asn Glu Asp Glu Asn Lys Asp Ser Glu Lys Ser Xaa Asp Ala Val Ser 
                805                 810                 815     


Ala Ala Asp Ser Ala Asn Gly Ser Val Gly Ala Ala Xaa Ala Pro Ala 
            820                 825                 830         


Gly Leu Pro Ser Asn Pro Leu Ala Phe Asn Pro Phe Leu Leu Ser Xaa 
        835                 840                 845             


Met Ala Pro Gly Leu Phe Tyr Pro Ser Met Phe Leu Pro Pro Gly Leu 
    850                 855                 860                 


Gly Gly Leu Xaa Leu Pro Gly Phe Pro Ala Leu Ala Gly Leu Gln Asn 
865                 870                 875                 880 


Ala Val Gly Ser Ser Glu Glu Lys Ala Ala Asp Lys Ala Glu Gly Gly 
                885                 890                 895     


Pro Phe Lys Asp Gly Glu Xaa Leu Glu Gly Ser Asp Ala Glu Glu Ser 
            900                 905                 910         


Leu Asp Lys Xaa Ala Glu Ser Ser Leu Leu Glu Asp Glu Ile Ala Gln 
        915                 920                 925             


Gly Glu Glu Leu Asp Ser Leu Asp Gly Gly Asp Glu Ile Glu Asn Asn 
    930                 935                 940                 


Glu Asn Asp Glu 
945             


<210> 6010
<211> 1138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<400> 6010
Met Ala Asp Pro Gly Met Met Ser Leu Phe Gly Glu Asp Gly Asn Ile 
1               5                   10                  15      


Phe Ser Glu Gly Leu Glu Gly Leu Gly Glu Cys Gly Tyr Pro Glu Asn 
            20                  25                  30          


Pro Val Asn Pro Met Gly Gln Gln Met Pro Ile Asp Gln Gly Phe Ala 
        35                  40                  45              


Ser Leu Gln Pro Ser Leu His His Pro Ser Xaa Asn Gln Asn Gln Xaa 
    50                  55                  60                  


Lys Leu Xaa His Phe Asp His Tyr Asn Gln Tyr Glu Gln Gln Lys Met 
65                  70                  75                  80  


His Leu Met Asp Gln Pro Asn Arg Met Met Ser Asn Xaa Pro Gly Asn 
                85                  90                  95      


Gly Leu Ala Ser Pro His Ser Gln Tyr His Xaa Pro Pro Val Pro Gln 
            100                 105                 110         


Val Pro His Gly Gly Ser Gly Gly Gly Gln Met Gly Val Tyr Pro Gly 
        115                 120                 125             


Met Gln Asn Glu Arg His Gly Gln Ser Phe Val Asp Ser Ser Ser Met 
    130                 135                 140                 


Trp Gly Pro Arg Ala Val Gln Val Pro Asp Gln Ile Arg Ala Pro Tyr 
145                 150                 155                 160 


Gln Gln Gln Gln Pro Gln Pro Gln Pro Pro Gln Pro Ala Pro Ser Gly 
                165                 170                 175     


Pro Pro Ala Gln Gly His Pro Gln His Met Gln Gln Met Gly Ser Tyr 
            180                 185                 190         


Met Ala Arg Gly Asp Phe Ser Met Gln Gln His Gly Gln Pro Gln Gln 
        195                 200                 205             


Arg Met Ser Gln Phe Ser Gln Gly Gln Glu Gly Leu Asn Gln Gly Asn 
    210                 215                 220                 


Pro Phe Ile Ala Xaa Ser Gly Pro Gly His Leu Ser His Val Pro Gln 
225                 230                 235                 240 


Gln Ser Pro Ser Met Ala Pro Ser Leu Arg His Ser Val Gln Gln Phe 
                245                 250                 255     


His His His Pro Ser Xaa Ala Leu His Gly Glu Ser Val Ala His Ser 
            260                 265                 270         


Pro Arg Phe Ser Pro Asn Pro Pro Gln Gln Gly Ala Val Arg Pro Gln 
        275                 280                 285             


Xaa Leu Asn Phe Ser Ser Arg Ser Gln Xaa Val Pro Ser Pro Xaa Ile 
    290                 295                 300                 


Asn Asn Ser Gly Gln Tyr Ser Arg Tyr Pro Tyr Ser Asn Leu Asn Gln 
305                 310                 315                 320 


Gly Leu Val Asn Asn Xaa Gly Met Asn Gln Asn Leu Gly Leu Xaa Asn 
                325                 330                 335     


Asn Xaa Pro Met Asn Gln Ser Val Pro Arg Tyr Pro Asn Ala Val Gly 
            340                 345                 350         


Phe Pro Ser Asn Ser Gly Gln Gly Leu Met His Gln Gln Pro Ile His 
        355                 360                 365             


Pro Ser Gly Ser Leu Asn Gln Met Asn Xaa Gln Xaa Met His Pro Ser 
    370                 375                 380                 


Gln Pro Gln Gly Xaa Tyr Ala Ser Pro Pro Pro Met Ser Pro Met Lys 
385                 390                 395                 400 


Ala Met Ser Asn Pro Ala Gly Xaa Pro Pro Pro Gln Val Arg Pro Gly 
                405                 410                 415     


Ser Ala Gly Ile Pro Met Glu Val Gly Ser Tyr Pro Asn Met Pro His 
            420                 425                 430         


Pro Gln Pro Ser His Gln Pro Pro Gly Ala Met Gly Ile Gly Gln Arg 
        435                 440                 445             


Asn Met Gly Pro Arg Asn Met Gln Gln Ser Arg Pro Phe Ile Gly Met 
    450                 455                 460                 


Ser Ser Ala Pro Arg Glu Leu Xaa Gly His Met Arg Pro Asn Gly Cys 
465                 470                 475                 480 


Pro Gly Val Gly Leu Gly Asp Pro Gln Ala Ile Gln Glu Arg Leu Ile 
                485                 490                 495     


Pro Gly Gln Gln His Pro Gly Gln Gln Pro Ser Phe Gln Gln Leu Pro 
            500                 505                 510         


Xaa Cys Pro Pro Leu Gln Pro His Pro Gly Leu His His Gln Ser Ser 
        515                 520                 525             


Pro Pro His Pro His His Gln Pro Trp Ala Gln Leu His Pro Ser Pro 
    530                 535                 540                 


Gln Asn Xaa Pro Gln Lys Val Pro Val His Gln His Ser Pro Ser Glu 
545                 550                 555                 560 


Pro Phe Leu Glu Lys Pro Val Pro Asp Met Xaa Gln Val Ser Gly Pro 
                565                 570                 575     


Asn Ala Gln Leu Val Lys Ser Asp Asp Tyr Leu Pro Ser Ile Glu Gln 
            580                 585                 590         


Gln Pro Gln Gln Lys Lys Lys Lys Lys Lys Asn Asn His Ile Val Ala 
        595                 600                 605             


Glu Asp Pro Ser Lys Gly Phe Gly Lys Asp Asp Phe Pro Gly Gly Val 
    610                 615                 620                 


Asp Asn Gln Glu Leu Asn Arg Asn Ser Leu Asp Gly Ser Gln Glu Glu 
625                 630                 635                 640 


Lys Lys Lys Lys Lys Arg Ser Lys Ala Lys Lys Asp Pro Lys Glu Pro 
                645                 650                 655     


Lys Glu Pro Lys Glu Lys Lys Glu Pro Lys Glu Pro Lys Xaa Pro Lys 
            660                 665                 670         


Ala Pro Lys Ile Pro Lys Glu Pro Lys Glu Lys Lys Ala Lys Xaa Ala 
        675                 680                 685             


Xaa Pro Lys Pro Lys Ser Ser Lys Lys Ser Ser Asn Lys Lys Pro Asp 
    690                 695                 700                 


Ser Glu Ala Ser Ala Leu Lys Lys Lys Val Asn Lys Gly Lys Xaa Glu 
705                 710                 715                 720 


Gly Ser Glu Asn Ser Asp Leu Asp Lys Xaa Pro Pro Pro Ser Pro Pro 
                725                 730                 735     


Pro Glu Glu Asp Glu Asp Pro Gly Val Gln Lys Arg Arg Ser Ser Arg 
            740                 745                 750         


Gln Val Lys Arg Lys Arg Tyr Xaa Glu Asp Leu Glu Phe Lys Ile Ser 
        755                 760                 765             


Asp Glu Glu Ala Asp Asp Ala Asp Ala Ala Gly Arg Asp Ser Pro Ser 
    770                 775                 780                 


Asn Xaa Ser Gln Ser Glu Gln Gln Glu Ser Val Asp Ala Glu Gly Pro 
785                 790                 795                 800 


Val Val Glu Lys Ile Met Ser Ser Arg Ser Val Lys Lys Gln Lys Glu 
                805                 810                 815     


Ser Gly Glu Glu Val Glu Ile Glu Glu Phe Tyr Val Lys Tyr Lys Asn 
            820                 825                 830         


Phe Ser Tyr Leu His Cys Gln Trp Ala Ser Ile Glu Asp Leu Glu Lys 
        835                 840                 845             


Asp Lys Arg Ile Gln Gln Lys Ile Lys Arg Phe Lys Ala Lys Gln Gly 
    850                 855                 860                 


Gln Asn Lys Phe Leu Ser Glu Ile Glu Asp Glu Leu Phe Asn Pro Asp 
865                 870                 875                 880 


Tyr Val Glu Val Asp Arg Ile Met Asp Phe Ala Arg Ser Xaa Asp Asp 
                885                 890                 895     


Arg Gly Glu Pro Val Xaa His Tyr Leu Val Lys Trp Cys Ser Leu Pro 
            900                 905                 910         


Tyr Glu Asp Ser Xaa Trp Glu Arg Arg Gln Asp Ile Asp Gln Ala Lys 
        915                 920                 925             


Ile Glu Glu Phe Glu Lys Leu Met Ser Arg Glu Pro Glu Xaa Glu Arg 
    930                 935                 940                 


Val Glu Arg Pro Pro Ala Asp Asp Trp Lys Lys Ser Glu Ser Ser Arg 
945                 950                 955                 960 


Glu Tyr Lys Asn Asn Asn Lys Leu Arg Glu Tyr Gln Leu Glu Gly Val 
                965                 970                 975     


Asn Trp Leu Leu Phe Asn Trp Tyr Asn Met Arg Asn Cys Ile Leu Ala 
            980                 985                 990         


Asp Glu Met Gly Leu Gly Lys Xaa  Ile Gln Ser Ile Xaa  Phe Leu Tyr 
        995                 1000                 1005             


Glu Ile  Tyr Leu Lys Gly Ile  His Gly Pro Phe Leu  Val Ile Ala 
    1010                 1015                 1020             


Pro Leu  Ser Xaa Ile Pro Asn  Trp Glu Arg Glu Phe  Arg Xaa Trp 
    1025                 1030                 1035             


Xaa Glu  Leu Asn Val Val Val  Tyr His Gly Ser Gln  Ala Ser Arg 
    1040                 1045                 1050             


Arg Xaa  Ile Gln Leu Tyr Glu  Met Tyr Phe Lys Asp  Pro Gln Gly 
    1055                 1060                 1065             


Arg Val  Ile Lys Gly Ser Tyr  Lys Phe His Ala Ile  Ile Xaa Xaa 
    1070                 1075                 1080             


Phe Glu  Met Ile Leu Xaa Asp  Cys Pro Glu Leu Arg  Asn Ile Pro 
    1085                 1090                 1095             


Trp Arg  Cys Val Val Ile Asp  Glu Ala His Arg Leu  Lys Asn Arg 
    1100                 1105                 1110             


Asn Cys  Lys Leu Leu Glu Gly  Leu Lys Met Met Asp  Leu Val Ser 
    1115                 1120                 1125             


Asp His  Ile Gly Asp Cys Xaa  Glu Pro Glu 
    1130                 1135             


<210> 6011
<211> 2997
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1211)..(1211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1244)..(1244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1272)..(1272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1366)..(1366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1380)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1416)..(1416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1449)..(1449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1495)..(1495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1497)..(1497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1499)..(1499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1508)..(1508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1521)..(1521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1562)..(1562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1622)..(1622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1635)..(1635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1641)..(1641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1645)..(1645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1669)..(1669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1671)..(1671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1676)..(1676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1703)..(1703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1836)..(1836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1860)..(1860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1862)..(1862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1888)..(1888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1906)..(1906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1908)..(1908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1910)..(1911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1918)..(1918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1937)..(1937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1967)..(1967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1980)..(1980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2047)..(2047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2054)..(2054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2112)..(2112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2140)..(2140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2153)..(2153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2196)..(2196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2227)..(2227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2278)..(2278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2283)..(2283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2304)..(2304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2350)..(2350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2352)..(2353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2381)..(2382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2452)..(2452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2455)..(2455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2472)..(2472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2480)..(2480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2492)..(2492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2494)..(2494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2532)..(2532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2542)..(2542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2551)..(2551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2554)..(2554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2567)..(2567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2578)..(2578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2600)..(2600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2602)..(2602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2640)..(2640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2642)..(2642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2686)..(2686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2705)..(2705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2738)..(2738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2756)..(2756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2781)..(2781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2784)..(2784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2824)..(2824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2827)..(2829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2840)..(2840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2861)..(2861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2878)..(2878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2897)..(2897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2917)..(2917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2952)..(2952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2965)..(2965)
<223> Selenocysteine

<400> 6011
Met Ala Asp Pro Gly Met Met Ser Leu Phe Gly Glu Asp Gly Asn Ile 
1               5                   10                  15      


Phe Ser Glu Gly Leu Glu Gly Leu Gly Glu Cys Gly Tyr Pro Glu Asn 
            20                  25                  30          


Pro Val Asn Pro Met Gly Gln Gln Met Pro Ile Asp Gln Gly Phe Ala 
        35                  40                  45              


Ser Leu Gln Pro Ser Leu His His Pro Ser Xaa Asn Gln Asn Gln Xaa 
    50                  55                  60                  


Lys Leu Xaa His Phe Asp His Tyr Asn Gln Tyr Glu Gln Gln Lys Met 
65                  70                  75                  80  


His Leu Met Asp Gln Pro Asn Arg Met Met Ser Asn Xaa Pro Gly Asn 
                85                  90                  95      


Gly Leu Ala Ser Pro His Ser Gln Tyr His Xaa Pro Pro Val Pro Gln 
            100                 105                 110         


Val Pro His Gly Gly Ser Gly Gly Gly Gln Met Gly Val Tyr Pro Gly 
        115                 120                 125             


Met Gln Asn Glu Arg His Gly Gln Ser Phe Val Asp Ser Ser Ser Met 
    130                 135                 140                 


Trp Gly Pro Arg Ala Val Gln Val Pro Asp Gln Ile Arg Ala Pro Tyr 
145                 150                 155                 160 


Gln Gln Gln Gln Pro Gln Pro Gln Pro Pro Gln Pro Ala Pro Ser Gly 
                165                 170                 175     


Pro Pro Ala Gln Gly His Pro Gln His Met Gln Gln Met Gly Ser Tyr 
            180                 185                 190         


Met Ala Arg Gly Asp Phe Ser Met Gln Gln His Gly Gln Pro Gln Gln 
        195                 200                 205             


Arg Met Ser Gln Phe Ser Gln Gly Gln Glu Gly Leu Asn Gln Gly Asn 
    210                 215                 220                 


Pro Phe Ile Ala Xaa Ser Gly Pro Gly His Leu Ser His Val Pro Gln 
225                 230                 235                 240 


Gln Ser Pro Ser Met Ala Pro Ser Leu Arg His Ser Val Gln Gln Phe 
                245                 250                 255     


His His His Pro Ser Xaa Ala Leu His Gly Glu Ser Val Ala His Ser 
            260                 265                 270         


Pro Arg Phe Ser Pro Asn Pro Pro Gln Gln Gly Ala Val Arg Pro Gln 
        275                 280                 285             


Xaa Leu Asn Phe Ser Ser Arg Ser Gln Xaa Val Pro Ser Pro Xaa Ile 
    290                 295                 300                 


Asn Asn Ser Gly Gln Tyr Ser Arg Tyr Pro Tyr Ser Asn Leu Asn Gln 
305                 310                 315                 320 


Gly Leu Val Asn Asn Xaa Gly Met Asn Gln Asn Leu Gly Leu Xaa Asn 
                325                 330                 335     


Asn Xaa Pro Met Asn Gln Ser Val Pro Arg Tyr Pro Asn Ala Val Gly 
            340                 345                 350         


Phe Pro Ser Asn Ser Gly Gln Gly Leu Met His Gln Gln Pro Ile His 
        355                 360                 365             


Pro Ser Gly Ser Leu Asn Gln Met Asn Xaa Gln Xaa Met His Pro Ser 
    370                 375                 380                 


Gln Pro Gln Gly Xaa Tyr Ala Ser Pro Pro Pro Met Ser Pro Met Lys 
385                 390                 395                 400 


Ala Met Ser Asn Pro Ala Gly Xaa Pro Pro Pro Gln Val Arg Pro Gly 
                405                 410                 415     


Ser Ala Gly Ile Pro Met Glu Val Gly Ser Tyr Pro Asn Met Pro His 
            420                 425                 430         


Pro Gln Pro Ser His Gln Pro Pro Gly Ala Met Gly Ile Gly Gln Arg 
        435                 440                 445             


Asn Met Gly Pro Arg Asn Met Gln Gln Ser Arg Pro Phe Ile Gly Met 
    450                 455                 460                 


Ser Ser Ala Pro Arg Glu Leu Xaa Gly His Met Arg Pro Asn Gly Cys 
465                 470                 475                 480 


Pro Gly Val Gly Leu Gly Asp Pro Gln Ala Ile Gln Glu Arg Leu Ile 
                485                 490                 495     


Pro Gly Gln Gln His Pro Gly Gln Gln Pro Ser Phe Gln Gln Leu Pro 
            500                 505                 510         


Xaa Cys Pro Pro Leu Gln Pro His Pro Gly Leu His His Gln Ser Ser 
        515                 520                 525             


Pro Pro His Pro His His Gln Pro Trp Ala Gln Leu His Pro Ser Pro 
    530                 535                 540                 


Gln Asn Xaa Pro Gln Lys Val Pro Val His Gln His Ser Pro Ser Glu 
545                 550                 555                 560 


Pro Phe Leu Glu Lys Pro Val Pro Asp Met Xaa Gln Val Ser Gly Pro 
                565                 570                 575     


Asn Ala Gln Leu Val Lys Ser Asp Asp Tyr Leu Pro Ser Ile Glu Gln 
            580                 585                 590         


Gln Pro Gln Gln Lys Lys Lys Lys Lys Lys Asn Asn His Ile Val Ala 
        595                 600                 605             


Glu Asp Pro Ser Lys Gly Phe Gly Lys Asp Asp Phe Pro Gly Gly Val 
    610                 615                 620                 


Asp Asn Gln Glu Leu Asn Arg Asn Ser Leu Asp Gly Ser Gln Glu Glu 
625                 630                 635                 640 


Lys Lys Lys Lys Lys Arg Ser Lys Ala Lys Lys Asp Pro Lys Glu Pro 
                645                 650                 655     


Lys Glu Pro Lys Glu Lys Lys Glu Pro Lys Glu Pro Lys Xaa Pro Lys 
            660                 665                 670         


Ala Pro Lys Ile Pro Lys Glu Pro Lys Glu Lys Lys Ala Lys Xaa Ala 
        675                 680                 685             


Xaa Pro Lys Pro Lys Ser Ser Lys Lys Ser Ser Asn Lys Lys Pro Asp 
    690                 695                 700                 


Ser Glu Ala Ser Ala Leu Lys Lys Lys Val Asn Lys Gly Lys Xaa Glu 
705                 710                 715                 720 


Gly Ser Glu Asn Ser Asp Leu Asp Lys Xaa Pro Pro Pro Ser Pro Pro 
                725                 730                 735     


Pro Glu Glu Asp Glu Asp Pro Gly Val Gln Lys Arg Arg Ser Ser Arg 
            740                 745                 750         


Gln Val Lys Arg Lys Arg Tyr Xaa Glu Asp Leu Glu Phe Lys Ile Ser 
        755                 760                 765             


Asp Glu Glu Ala Asp Asp Ala Asp Ala Ala Gly Arg Asp Ser Pro Ser 
    770                 775                 780                 


Asn Xaa Ser Gln Ser Glu Gln Gln Glu Ser Val Asp Ala Glu Gly Pro 
785                 790                 795                 800 


Val Val Glu Lys Ile Met Ser Ser Arg Ser Val Lys Lys Gln Lys Glu 
                805                 810                 815     


Ser Gly Glu Glu Val Glu Ile Glu Glu Phe Tyr Val Lys Tyr Lys Asn 
            820                 825                 830         


Phe Ser Tyr Leu His Cys Gln Trp Ala Ser Ile Glu Asp Leu Glu Lys 
        835                 840                 845             


Asp Lys Arg Ile Gln Gln Lys Ile Lys Arg Phe Lys Ala Lys Gln Gly 
    850                 855                 860                 


Gln Asn Lys Phe Leu Ser Glu Ile Glu Asp Glu Leu Phe Asn Pro Asp 
865                 870                 875                 880 


Tyr Val Glu Val Asp Arg Ile Met Asp Phe Ala Arg Ser Xaa Asp Asp 
                885                 890                 895     


Arg Gly Glu Pro Val Xaa His Tyr Leu Val Lys Trp Cys Ser Leu Pro 
            900                 905                 910         


Tyr Glu Asp Ser Xaa Trp Glu Arg Arg Gln Asp Ile Asp Gln Ala Lys 
        915                 920                 925             


Ile Glu Glu Phe Glu Lys Leu Met Ser Arg Glu Pro Glu Xaa Glu Arg 
    930                 935                 940                 


Val Glu Arg Pro Pro Ala Asp Asp Trp Lys Lys Ser Glu Ser Ser Arg 
945                 950                 955                 960 


Glu Tyr Lys Asn Asn Asn Lys Leu Arg Glu Tyr Gln Leu Glu Gly Val 
                965                 970                 975     


Asn Trp Leu Leu Phe Asn Trp Tyr Asn Met Arg Asn Cys Ile Leu Ala 
            980                 985                 990         


Asp Glu Met Gly Leu Gly Lys Xaa  Ile Gln Ser Ile Xaa  Phe Leu Tyr 
        995                 1000                 1005             


Glu Ile  Tyr Leu Lys Gly Ile  His Gly Pro Phe Leu  Val Ile Ala 
    1010                 1015                 1020             


Pro Leu  Ser Xaa Ile Pro Asn  Trp Glu Arg Glu Phe  Arg Xaa Trp 
    1025                 1030                 1035             


Xaa Glu  Leu Asn Val Val Val  Tyr His Gly Ser Gln  Ala Ser Arg 
    1040                 1045                 1050             


Arg Xaa  Ile Gln Leu Tyr Glu  Met Tyr Phe Lys Asp  Pro Gln Gly 
    1055                 1060                 1065             


Arg Val  Ile Lys Gly Ser Tyr  Lys Phe His Ala Ile  Ile Xaa Xaa 
    1070                 1075                 1080             


Phe Glu  Met Ile Leu Xaa Asp  Cys Pro Glu Leu Arg  Asn Ile Pro 
    1085                 1090                 1095             


Trp Arg  Cys Val Val Ile Asp  Glu Ala His Arg Leu  Lys Asn Arg 
    1100                 1105                 1110             


Asn Cys  Lys Leu Leu Glu Gly  Leu Lys Met Met Asp  Leu Glu His 
    1115                 1120                 1125             


Lys Val  Leu Leu Xaa Gly Xaa  Pro Leu Gln Asn Xaa  Val Glu Glu 
    1130                 1135                 1140             


Leu Phe  Ser Leu Leu His Phe  Leu Glu Pro Ser Arg  Phe Pro Ser 
    1145                 1150                 1155             


Glu Xaa  Xaa Phe Met Gln Glu  Phe Gly Asp Leu Lys  Xaa Glu Glu 
    1160                 1165                 1170             


Gln Val  Gln Lys Leu Gln Ala  Ile Leu Lys Pro Met  Met Leu Arg 
    1175                 1180                 1185             


Arg Leu  Lys Glu Asp Val Glu  Lys Asn Leu Ala Pro  Lys Glu Glu 
    1190                 1195                 1200             


Xaa Ile  Ile Glu Val Glu Leu  Xaa Asn Ile Gln Lys  Lys Tyr Tyr 
    1205                 1210                 1215             


Arg Ala  Ile Leu Glu Lys Asn  Phe Xaa Phe Leu Ser  Lys Gly Gly 
    1220                 1225                 1230             


Gly Gln  Ala Asn Val Pro Asn  Leu Leu Asn Xaa Met  Met Glu Leu 
    1235                 1240                 1245             


Arg Lys  Cys Cys Asn His Pro  Tyr Leu Ile Asn Gly  Ala Glu Glu 
    1250                 1255                 1260             


Lys Ile  Leu Glu Glu Phe Lys  Glu Xaa His Asn Ala  Glu Ser Pro 
    1265                 1270                 1275             


Asp Phe  Gln Leu Gln Ala Met  Ile Gln Ala Ala Gly  Lys Leu Val 
    1280                 1285                 1290             


Leu Ile  Asp Lys Leu Leu Pro  Lys Leu Lys Ala Gly  Gly His Arg 
    1295                 1300                 1305             


Val Leu  Ile Phe Ser Gln Met  Val Arg Cys Leu Asp  Ile Leu Glu 
    1310                 1315                 1320             


Asp Tyr  Leu Ile Gln Arg Arg  Tyr Pro Tyr Glu Arg  Ile Asp Gly 
    1325                 1330                 1335             


Arg Val  Arg Gly Asn Leu Arg  Gln Ala Ala Ile Asp  Arg Phe Ser 
    1340                 1345                 1350             


Lys Pro  Asp Ser Asp Arg Phe  Val Phe Leu Leu Cys  Xaa Arg Ala 
    1355                 1360                 1365             


Gly Gly  Leu Gly Ile Asn Leu  Xaa Ala Ala Asp Xaa  Cys Ile Ile 
    1370                 1375                 1380             


Phe Asp  Ser Asp Trp Asn Pro  Gln Asn Asp Leu Gln  Ala Gln Ala 
    1385                 1390                 1395             


Arg Cys  His Arg Ile Gly Gln  Ser Lys Ser Val Lys  Ile Tyr Arg 
    1400                 1405                 1410             


Leu Ile  Xaa Arg Asn Ser Tyr  Glu Arg Glu Met Phe  Asp Lys Ala 
    1415                 1420                 1425             


Ser Leu  Lys Leu Gly Leu Asp  Lys Ala Val Leu Gln  Ser Met Ser 
    1430                 1435                 1440             


Gly Arg  Glu Asn Ala Xaa Asn  Gly Val Gln Gln Leu  Ser Lys Lys 
    1445                 1450                 1455             


Glu Ile  Glu Asp Leu Leu Arg  Lys Gly Ala Tyr Gly  Ala Leu Met 
    1460                 1465                 1470             


Asp Glu  Glu Asp Glu Gly Ser  Lys Phe Cys Glu Glu  Asp Ile Asp 
    1475                 1480                 1485             


Gln Ile  Leu Leu Arg Arg Xaa  His Xaa Ile Xaa Ile  Glu Ser Glu 
    1490                 1495                 1500             


Gly Lys  Gly Ser Xaa Phe Ala  Lys Ala Ser Phe Val  Ala Ser Gly 
    1505                 1510                 1515             


Asn Arg  Xaa Asp Ile Ser Leu  Asp Asp Pro Asn Phe  Trp Gln Lys 
    1520                 1525                 1530             


Trp Ala  Lys Lys Ala Glu Leu  Asp Ile Asp Ala Leu  Asn Gly Arg 
    1535                 1540                 1545             


Asn Asn  Leu Val Ile Asp Xaa  Pro Arg Val Arg Lys  Gln Xaa Arg 
    1550                 1555                 1560             


Leu Tyr  Ser Ala Val Lys Glu  Asp Glu Leu Met Glu  Phe Ser Asp 
    1565                 1570                 1575             


Leu Glu  Ser Asp Ser Glu Glu  Lys Pro Cys Ala Lys  Pro Arg Arg 
    1580                 1585                 1590             


Pro Gln  Asp Lys Ser Gln Gly  Tyr Ala Arg Ser Glu  Cys Phe Arg 
    1595                 1600                 1605             


Val Glu  Lys Asn Leu Leu Val  Tyr Gly Trp Gly Arg  Trp Xaa Asp 
    1610                 1615                 1620             


Ile Leu  Ser His Gly Arg Tyr  Lys Arg Gln Leu Xaa  Glu Gln Asp 
    1625                 1630                 1635             


Val Glu  Xaa Ile Cys Arg Xaa  Ile Leu Val Tyr Cys  Leu Asn His 
    1640                 1645                 1650             


Tyr Lys  Gly Asp Glu Asn Ile  Lys Ser Phe Ile Trp  Asp Leu Ile 
    1655                 1660                 1665             


Xaa Pro  Xaa Ala Asp Gly Gln  Xaa Arg Ala Leu Val  Asn His Ser 
    1670                 1675                 1680             


Gly Leu  Ser Ala Pro Val Pro  Arg Gly Arg Lys Gly  Lys Lys Val 
    1685                 1690                 1695             


Lys Ala  Gln Ser Xaa Gln Pro  Val Val Gln Asp Ala  Asp Trp Leu 
    1700                 1705                 1710             


Ala Ser  Cys Asn Pro Asp Ala  Leu Phe Gln Glu Asp  Ser Tyr Lys 
    1715                 1720                 1725             


Lys His  Leu Lys His His Cys  Asn Lys Val Leu Leu  Arg Val Arg 
    1730                 1735                 1740             


Met Leu  Tyr Tyr Leu Arg Gln  Glu Val Ile Gly Asp  Gln Ala Asp 
    1745                 1750                 1755             


Lys Ile  Leu Glu Gly Ala Asp  Ser Ser Glu Ala Asp  Val Trp Ile 
    1760                 1765                 1770             


Pro Glu  Pro Phe His Ala Glu  Val Pro Ala Asp Trp  Trp Asp Lys 
    1775                 1780                 1785             


Glu Ala  Asp Lys Ser Leu Leu  Ile Gly Val Phe Lys  His Gly Tyr 
    1790                 1795                 1800             


Glu Lys  Tyr Asn Ser Met Arg  Ala Asp Pro Ala Leu  Cys Phe Leu 
    1805                 1810                 1815             


Glu Arg  Val Gly Met Pro Asp  Ala Lys Ala Ile Ala  Ala Glu Gln 
    1820                 1825                 1830             


Arg Gly  Xaa Asp Met Leu Ala  Asp Gly Gly Asp Gly  Gly Glu Phe 
    1835                 1840                 1845             


Asp Arg  Glu Asp Glu Asp Pro  Glu Tyr Lys Pro Xaa  Arg Xaa Pro 
    1850                 1855                 1860             


Phe Lys  Asp Glu Ile Asp Glu  Phe Ala Asn Ser Pro  Ser Glu Asp 
    1865                 1870                 1875             


Lys Glu  Glu Ser Met Glu Ile  His Ala Xaa Gly Lys  His Ser Glu 
    1880                 1885                 1890             


Ser Asn  Ala Glu Leu Gly Gln  Leu Tyr Trp Pro Asn  Xaa Ser Xaa 
    1895                 1900                 1905             


Leu Xaa  Xaa Arg Leu Arg Arg  Leu Ile Xaa Ala Tyr  Gln Arg Ser 
    1910                 1915                 1920             


Tyr Lys  Arg Gln Gln Met Arg  Gln Glu Ala Leu Met  Lys Xaa Asp 
    1925                 1930                 1935             


Arg Arg  Arg Arg Arg Pro Arg  Glu Glu Val Arg Ala  Leu Glu Ala 
    1940                 1945                 1950             


Glu Arg  Glu Ala Ile Ile Ser  Glu Lys Arg Gln Lys  Trp Xaa Arg 
    1955                 1960                 1965             


Arg Glu  Glu Ala Asp Phe Tyr  Arg Val Val Ser Xaa  Phe Gly Val 
    1970                 1975                 1980             


Ile Phe  Asp Pro Val Lys Gln  Gln Phe Asp Trp Asn  Gln Phe Arg 
    1985                 1990                 1995             


Ala Phe  Ala Arg Leu Asp Lys  Lys Ser Asp Glu Ser  Leu Glu Lys 
    2000                 2005                 2010             


Tyr Phe  Ser Cys Phe Val Ala  Met Cys Arg Arg Val  Cys Arg Met 
    2015                 2020                 2025             


Pro Val  Lys Pro Asp Asp Glu  Pro Pro Asp Leu Ser  Ser Ile Ile 
    2030                 2035                 2040             


Glu Pro  Ile Xaa Glu Glu Arg  Ala Ser Arg Xaa Leu  Tyr Arg Ile 
    2045                 2050                 2055             


Glu Leu  Leu Arg Lys Ile Arg  Glu Gln Val Leu His  His Pro Gln 
    2060                 2065                 2070             


Leu Gly  Glu Arg Leu Lys Leu  Cys Gln Pro Ser Leu  Asp Leu Pro 
    2075                 2080                 2085             


Glu Trp  Trp Glu Cys Gly Arg  His Asp Arg Asp Leu  Leu Val Gly 
    2090                 2095                 2100             


Ala Ala  Lys His Gly Val Ser  Arg Xaa Asp Tyr His  Ile Leu Asn 
    2105                 2110                 2115             


Asp Pro  Glu Leu Ser Phe Leu  Asp Ala His Lys Asn  Phe Ala Gln 
    2120                 2125                 2130             


Asn Arg  Gly Ala Gly Asn Xaa  Ser Ser Leu Asn Pro  Leu Ala Val 
    2135                 2140                 2145             


Gly Phe  Val Gln Xaa Pro Pro  Val Ile Ser Ser Ala  His Ile Gln 
    2150                 2155                 2160             


Asp Glu  Arg Val Leu Glu Gln  Ala Glu Gly Lys Val  Glu Glu Pro 
    2165                 2170                 2175             


Glu Asn  Pro Ala Ala Lys Glu  Lys Cys Glu Gly Lys  Glu Glu Glu 
    2180                 2185                 2190             


Glu Glu  Xaa Asp Gly Ser Gly  Lys Glu Ser Lys Gln  Glu Cys Glu 
    2195                 2200                 2205             


Ala Glu  Ala Ser Ser Val Lys  Asn Glu Leu Lys Gly  Val Glu Val 
    2210                 2215                 2220             


Gly Ala  Asp Xaa Gly Ser Lys  Ser Ile Ser Glu Lys  Gly Ser Glu 
    2225                 2230                 2235             


Glu Asp  Glu Glu Glu Lys Leu  Glu Asp Asp Asp Lys  Ser Glu Glu 
    2240                 2245                 2250             


Ser Ser  Gln Pro Glu Ala Gly  Ala Val Ser Arg Gly  Lys Asn Phe 
    2255                 2260                 2265             


Asp Glu  Glu Ser Asn Ala Ser  Met Ser Xaa Ala Arg  Asp Glu Xaa 
    2270                 2275                 2280             


Arg Asp  Gly Phe Tyr Met Glu  Asp Gly Asp Pro Ser  Val Ala Gln 
    2285                 2290                 2295             


Leu Leu  His Glu Arg Xaa Phe  Ala Phe Ser Phe Trp  Pro Lys Asp 
    2300                 2305                 2310             


Arg Val  Met Ile Asn Arg Leu  Asp Asn Ile Cys Glu  Ala Val Leu 
    2315                 2320                 2325             


Lys Gly  Lys Trp Pro Val Asn  Arg Arg Gln Met Phe  Asp Phe Gln 
    2330                 2335                 2340             


Gly Leu  Ile Pro Gly Tyr Xaa  Pro Xaa Xaa Val Asp  Ser Pro Leu 
    2345                 2350                 2355             


Gln Lys  Arg Ser Phe Ala Glu  Leu Ser Met Val Gly  Gln Ala Ser 
    2360                 2365                 2370             


Ile Ser  Gly Ser Glu Asp Ile  Xaa Xaa Ser Pro Gln  Leu Ser Lys 
    2375                 2380                 2385             


Glu Asp  Ala Leu Asn Leu Ser  Val Pro Arg Gln Arg  Arg Arg Arg 
    2390                 2395                 2400             


Arg Arg  Lys Ile Glu Ile Glu  Ala Glu Arg Ala Ala  Lys Arg Arg 
    2405                 2410                 2415             


Asn Leu  Met Glu Met Val Ala  Gln Leu Arg Glu Ser  Gln Val Val 
    2420                 2425                 2430             


Ser Glu  Asn Gly Gln Glu Lys  Val Val Asp Leu Ser  Lys Ala Ser 
    2435                 2440                 2445             


Arg Glu  Ala Xaa Ser Ser Xaa  Ser Asn Phe Ser Ser  Leu Ser Ser 
    2450                 2455                 2460             


Lys Phe  Ile Leu Pro Asn Val  Ser Xaa Pro Val Ser  Asp Ala Phe 
    2465                 2470                 2475             


Lys Xaa  Gln Met Glu Leu Leu  Gln Ala Gly Leu Ser  Arg Xaa Pro 
    2480                 2485                 2490             


Xaa Arg  His Leu Leu Asn Gly  Ser Leu Val Asp Gly  Glu Pro Pro 
    2495                 2500                 2505             


Met Lys  Arg Arg Arg Gly Arg  Arg Lys Asn Val Glu  Gly Leu Asp 
    2510                 2515                 2520             


Leu Leu  Phe Met Ser His Lys  Arg Xaa Ser Leu Ser  Ala Glu Asp 
    2525                 2530                 2535             


Ala Glu  Val Xaa Lys Ala Phe  Glu Glu Asp Ile Glu  Xaa Pro Pro 
    2540                 2545                 2550             


Xaa Arg  Asn Ile Pro Ser Pro  Gly Gln Leu Asp Pro  Asp Xaa Arg 
    2555                 2560                 2565             


Ile Pro  Val Ile Asn Leu Glu  Asp Gly Xaa Arg Leu  Val Gly Glu 
    2570                 2575                 2580             


Asp Ala  Pro Lys Asn Lys Asp  Leu Val Glu Trp Leu  Lys Leu His 
    2585                 2590                 2595             


Pro Xaa  Tyr Xaa Val Asp Met  Pro Ser Tyr Val Pro  Lys Asn Ala 
    2600                 2605                 2610             


Asp Val  Leu Phe Ser Ser Phe  Gln Lys Pro Lys Gln  Lys Arg His 
    2615                 2620                 2625             


Arg Cys  Arg Asn Pro Asn Lys  Leu Asp Ile Asn Xaa  Leu Xaa Gly 
    2630                 2635                 2640             


Glu Glu  Arg Val Pro Val Val  Asn Lys Arg Asn Gly  Lys Lys Met 
    2645                 2650                 2655             


Gly Gly  Ala Met Ala Pro Pro  Met Lys Asp Leu Pro  Arg Trp Leu 
    2660                 2665                 2670             


Glu Glu  Asn Pro Glu Phe Ala  Val Ala Pro Asp Trp  Xaa Asp Ile 
    2675                 2680                 2685             


Val Lys  Gln Ser Gly Phe Val  Pro Glu Ser Met Phe  Asp Arg Leu 
    2690                 2695                 2700             


Leu Xaa  Gly Pro Val Val Arg  Gly Glu Gly Ala Ser  Arg Arg Gly 
    2705                 2710                 2715             


Arg Arg  Pro Lys Ser Glu Ile  Ala Arg Ala Ala Ala  Ala Ala Ala 
    2720                 2725                 2730             


Ala Val  Ala Ser Xaa Ser Gly  Ile Asn Pro Leu Leu  Val Asn Ser 
    2735                 2740                 2745             


Leu Phe  Ala Gly Met Asp Leu  Xaa Ser Leu Gln Asn  Leu Gln Asn 
    2750                 2755                 2760             


Leu Gln  Ser Leu Gln Leu Ala  Gly Leu Met Gly Phe  Pro Pro Gly 
    2765                 2770                 2775             


Leu Ala  Xaa Ala Ala Xaa Ala  Gly Gly Asp Ala Lys  Asn Pro Ala 
    2780                 2785                 2790             


Ala Val  Leu Pro Leu Met Leu  Pro Gly Met Ala Gly  Leu Pro Asn 
    2795                 2800                 2805             


Val Phe  Gly Leu Gly Gly Leu  Leu Asn Asn Pro Leu  Ser Ala Ala 
    2810                 2815                 2820             


Xaa Gly  Asn Xaa Xaa Xaa Ala  Ser Ser Gln Gly Glu  Pro Glu Asp 
    2825                 2830                 2835             


Ser Xaa  Ser Lys Gly Glu Glu  Lys Gly Asn Glu Asn  Glu Asp Glu 
    2840                 2845                 2850             


Asn Lys  Asp Ser Glu Lys Ser  Xaa Asp Ala Val Ser  Ala Ala Asp 
    2855                 2860                 2865             


Ser Ala  Asn Gly Ser Val Gly  Ala Ala Xaa Ala Pro  Ala Gly Leu 
    2870                 2875                 2880             


Pro Ser  Asn Pro Leu Ala Phe  Asn Pro Phe Leu Leu  Ser Xaa Met 
    2885                 2890                 2895             


Ala Pro  Gly Leu Phe Tyr Pro  Ser Met Phe Leu Pro  Pro Gly Leu 
    2900                 2905                 2910             


Gly Gly  Leu Xaa Leu Pro Gly  Phe Pro Ala Leu Ala  Gly Leu Gln 
    2915                 2920                 2925             


Asn Ala  Val Gly Ser Ser Glu  Glu Lys Ala Ala Asp  Lys Ala Glu 
    2930                 2935                 2940             


Gly Gly  Pro Phe Lys Asp Gly  Glu Xaa Leu Glu Gly  Ser Asp Ala 
    2945                 2950                 2955             


Glu Glu  Ser Leu Asp Lys Xaa  Ala Glu Ser Ser Leu  Leu Glu Asp 
    2960                 2965                 2970             


Glu Ile  Ala Gln Gly Glu Glu  Leu Asp Ser Leu Asp  Gly Gly Asp 
    2975                 2980                 2985             


Glu Ile  Glu Asn Asn Glu Asn  Asp Glu 
    2990                 2995         


<210> 6012
<211> 19
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 6012
Xaa Ser Ser Met Trp Gly Pro Arg Ala Val Gln Ala Cys Pro Arg His 
1               5                   10                  15      


Gln Gly Asn 
            


<210> 6013
<211> 226
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<400> 6013
Ile Asp Leu Val Cys Gln Ala Val Leu Ser Gly Lys Trp Pro Ser Ser 
1               5                   10                  15      


Arg Arg Ser Gln Glu Met Val Xaa Gly Gly Ile Leu Gly Pro Gly Asn 
            20                  25                  30          


His Leu Leu Asp Ser Pro Ser Leu Xaa Pro Gly Glu Tyr Gly Asp Ser 
        35                  40                  45              


Pro Val Pro Xaa Pro Arg Ser Ser Ser Ala Ala Ser Met Ala Glu Glu 
    50                  55                  60                  


Glu Ala Ser Ala Val Ser Xaa Ala Ala Ala Gln Phe Xaa Lys Leu Arg 
65                  70                  75                  80  


Arg Gly Met Asp Glu Lys Glu Phe Xaa Val Gln Ile Lys Asp Glu Glu 
                85                  90                  95      


Gly Leu Lys Leu Xaa Phe Gln Lys His Lys Leu Met Ala Asn Gly Val 
            100                 105                 110         


Met Gly Asp Gly His Pro Leu Phe His Lys Lys Lys Gly Asn Arg Lys 
        115                 120                 125             


Lys Leu Val Glu Tyr Met Glu Asp Arg Arg Lys Gln Lys Trp Gln Arg 
    130                 135                 140                 


Cys Lys Lys Asn Asn Lys Ala Glu Leu Asn Cys Leu Gly Met Glu Pro 
145                 150                 155                 160 


Val Gln Xaa Ala Asn Ser Arg Asn Gly Lys Lys Gly His His Xaa Glu 
                165                 170                 175     


Xaa Val Phe Asn Arg Val Leu Pro Gly Pro Ile Ala Pro Glu Ser Ser 
            180                 185                 190         


Lys Lys Arg Ala Arg Arg Met Arg Pro Asp Leu Ser Lys Met Met Ala 
        195                 200                 205             


Leu Met Gln Gly Gly Ser Xaa Gly Ser Leu Ser Leu His Asn Xaa Phe 
    210                 215                 220                 


Gln His 
225     


<210> 6014
<211> 2581
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (983)..(983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1293)..(1293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1338)..(1340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1342)..(1342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1364)..(1364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1398)..(1398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1405)..(1405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1410)..(1410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1444)..(1444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1475)..(1475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1481)..(1481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1516)..(1516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1543)..(1543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1559)..(1559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1622)..(1623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1647)..(1647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1731)..(1731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1746)..(1746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1754)..(1754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1799)..(1799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1804)..(1804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1812)..(1812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1821)..(1821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1831)..(1831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1839)..(1839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1844)..(1844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1879)..(1879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1886)..(1886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1945)..(1945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1982)..(1982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1990)..(1990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1993)..(1993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2012)..(2012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2014)..(2014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2023)..(2023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2037)..(2037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2050)..(2051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2095)..(2095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2107)..(2107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2124)..(2124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2139)..(2139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2187)..(2187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2204)..(2204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2215)..(2215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2234)..(2234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2240)..(2240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2252)..(2252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2264)..(2264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2313)..(2313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2324)..(2324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2386)..(2386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2398)..(2398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2400)..(2400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2438)..(2438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2446)..(2446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2466)..(2466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2490)..(2490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2522)..(2523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2527)..(2528)
<223> Selenocysteine

<400> 6014
Met Ala Asp Pro Ile Met Asp Leu Phe Asp Asp Pro Asn Leu Phe Gly 
1               5                   10                  15      


Leu Asp Ser Leu Xaa Asp Asp Ser Phe Asn Gln Val Xaa Gln Asp Pro 
            20                  25                  30          


Ile Glu Glu Ala Leu Gly Leu Pro Ser Ser Leu Asp Ser Leu Asp Gln 
        35                  40                  45              


Met Asn Gln Asp Gly Gly Gly Gly Asp Val Gly Asn Ser Ser Ala Ser 
    50                  55                  60                  


Glu Leu Val Pro Pro Pro Glu Glu Xaa Ala Pro Xaa Glu Leu Ser Lys 
65                  70                  75                  80  


Glu Ser Xaa Ala Pro Ala Pro Glu Ser Ile Xaa Leu His Asp Tyr Xaa 
                85                  90                  95      


Xaa Gln Pro Ala Ser Gln Glu Gln Pro Ala Gln Pro Val Leu Gln Xaa 
            100                 105                 110         


Ser Xaa Pro Xaa Ser Gly Leu Leu Gln Val Ser Lys Ser Gln Glu Ile 
        115                 120                 125             


Leu Ser Gln Gly Asn Pro Phe Met Gly Val Ser Ala Xaa Ala Val Ser 
    130                 135                 140                 


Ser Ser Ser Ala Gly Gly Gln Pro Pro Gln Ser Ala Pro Lys Ile Val 
145                 150                 155                 160 


Ile Leu Lys Ala Pro Pro Ser Ser Ser Val Xaa Gly Ala His Val Ala 
                165                 170                 175     


Gln Ile Gln Ala Gln Gly Ile Xaa Ser Xaa Ala Gln Pro Leu Val Ala 
            180                 185                 190         


Gly Xaa Ala Asn Gly Gly Lys Val Xaa Phe Xaa Lys Val Leu Xaa Gly 
        195                 200                 205             


Xaa Pro Leu Arg Pro Gly Val Ser Ile Val Ser Gly Asn Xaa Val Leu 
    210                 215                 220                 


Ala Ala Lys Val Pro Gly Asn Gln Ala Ala Val Gln Arg Ile Val Gln 
225                 230                 235                 240 


Pro Ser Arg Pro Val Lys Gln Leu Val Leu Gln Pro Val Lys Gly Ser 
                245                 250                 255     


Ala Pro Ala Gly Asn Pro Gly Ala Xaa Gly Pro Pro Leu Lys Pro Ala 
            260                 265                 270         


Val Xaa Leu Xaa Ser Xaa Pro Xaa Gln Gly Glu Ser Lys Arg Ile Xaa 
        275                 280                 285             


Leu Val Leu Gln Gln Pro Gln Ser Gly Gly Pro Gln Gly His Arg His 
    290                 295                 300                 


Val Val Leu Gly Ser Leu Pro Gly Lys Ile Val Leu Gln Gly Asn Gln 
305                 310                 315                 320 


Leu Ala Ala Leu Xaa Gln Ala Lys Asn Ala Gln Gly Gln Pro Ala Lys 
                325                 330                 335     


Val Val Xaa Ile Gln Leu Gln Val Gln Gln Pro Gln Gln Lys Ile Gln 
            340                 345                 350         


Ile Val Pro Gln Pro Pro Ser Ser Gln Pro Gln Pro Gln Gln Pro Pro 
        355                 360                 365             


Ser Xaa Gln Pro Val Xaa Leu Ser Ser Val Gln Gln Ala Gln Ile Met 
    370                 375                 380                 


Gly Pro Gly Gln Ser Pro Gly Gln Arg Leu Ser Val Pro Val Lys Val 
385                 390                 395                 400 


Val Leu Gln Pro Gln Ala Gly Ser Ser Gln Gly Ala Ser Ser Gly Leu 
                405                 410                 415     


Ser Val Val Lys Val Leu Ser Ala Ser Glu Val Ala Ala Leu Ser Ser 
            420                 425                 430         


Pro Ala Ser Ser Ala Pro His Ser Gly Gly Lys Xaa Gly Met Glu Glu 
        435                 440                 445             


Asn Arg Arg Leu Glu His Gln Lys Lys Gln Glu Lys Ala Asn Arg Ile 
    450                 455                 460                 


Val Ala Glu Ala Ile Ala Arg Ala Arg Ala Arg Gly Glu Gln Asn Ile 
465                 470                 475                 480 


Pro Arg Val Leu Asn Glu Asp Glu Leu Pro Ser Val Arg Pro Glu Glu 
                485                 490                 495     


Glu Gly Glu Lys Lys Arg Arg Lys Lys Ser Ala Gly Glu Arg Leu Lys 
            500                 505                 510         


Glu Glu Lys Pro Lys Lys Ser Lys Xaa Ser Gly Ala Ser Lys Xaa Lys 
        515                 520                 525             


Gly Lys Ser Lys Leu Asn Xaa Ile Xaa Pro Val Val Gly Lys Lys Arg 
    530                 535                 540                 


Lys Arg Asn Xaa Ser Ser Asp Asn Ser Asp Val Glu Val Met Pro Ala 
545                 550                 555                 560 


Gln Ser Pro Arg Glu Asp Glu Glu Ser Ser Ile Gln Lys Arg Arg Ser 
                565                 570                 575     


Asn Arg Gln Val Lys Arg Lys Lys Tyr Xaa Glu Asp Leu Asp Ile Lys 
            580                 585                 590         


Ile Xaa Asp Asp Glu Glu Glu Glu Glu Val Asp Val Xaa Gly Pro Ile 
        595                 600                 605             


Lys Pro Glu Pro Ile Leu Pro Glu Pro Val Gln Glu Pro Asp Gly Glu 
    610                 615                 620                 


Xaa Leu Pro Ser Met Gln Phe Phe Val Glu Asn Pro Ser Glu Glu Asp 
625                 630                 635                 640 


Ala Ala Ile Val Asp Lys Val Leu Ser Met Arg Ile Val Lys Lys Glu 
                645                 650                 655     


Leu Pro Ser Gly Gln Tyr Xaa Glu Ala Glu Glu Phe Phe Val Lys Tyr 
            660                 665                 670         


Lys Asn Tyr Ser Tyr Leu His Cys Glu Trp Ala Xaa Ile Ser Gln Leu 
        675                 680                 685             


Glu Lys Asp Lys Arg Ile His Gln Lys Leu Lys Arg Phe Lys Xaa Lys 
    690                 695                 700                 


Met Ala Gln Met Arg His Phe Phe His Glu Asp Glu Glu Pro Phe Asn 
705                 710                 715                 720 


Pro Asp Tyr Val Glu Val Asp Arg Ile Leu Asp Glu Ser His Ser Ile 
                725                 730                 735     


Asp Lys Asp Asn Gly Glu Pro Val Ile Tyr Tyr Leu Val Lys Trp Cys 
            740                 745                 750         


Ser Leu Pro Tyr Glu Asp Ser Xaa Trp Glu Leu Lys Glu Asp Val Asp 
        755                 760                 765             


Glu Gly Lys Ile Arg Glu Phe Lys Arg Ile Gln Ser Arg His Pro Glu 
    770                 775                 780                 


Leu Lys Arg Val Asn Arg Pro Gln Ala Ser Ala Trp Lys Lys Leu Glu 
785                 790                 795                 800 


Leu Ser His Glu Tyr Lys Asn Arg Asn Gln Leu Arg Glu Tyr Gln Leu 
                805                 810                 815     


Glu Gly Val Asn Trp Leu Leu Phe Asn Trp Tyr Asn Arg Gln Asn Cys 
            820                 825                 830         


Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Xaa Ile Gln Ser Ile Ala 
        835                 840                 845             


Phe Leu Gln Glu Val Tyr Asn Val Gly Ile His Gly Pro Phe Leu Val 
    850                 855                 860                 


Ile Ala Pro Leu Ser Xaa Ile Xaa Asn Trp Glu Arg Glu Phe Asn Xaa 
865                 870                 875                 880 


Trp Xaa Glu Met Asn Xaa Ile Val Tyr His Gly Ser Leu Ala Ser Arg 
                885                 890                 895     


Gln Met Ile Gln Gln Tyr Glu Met Tyr Cys Lys Asp Ser Arg Gly Arg 
            900                 905                 910         


Leu Ile Pro Gly Ala Tyr Lys Phe Asp Ala Leu Ile Xaa Xaa Phe Glu 
        915                 920                 925             


Met Ile Leu Ser Asp Cys Pro Glu Leu Arg Glu Ile Glu Trp Arg Cys 
    930                 935                 940                 


Val Ile Ile Asp Glu Ala His Arg Leu Lys Asn Arg Asn Cys Lys Leu 
945                 950                 955                 960 


Leu Asp Ser Leu Lys His Met Asp Leu Glu His Lys Val Leu Leu Xaa 
                965                 970                 975     


Gly Xaa Pro Leu Gln Asn Xaa Val Glu Glu Leu Phe Ser Leu Leu His 
            980                 985                 990         


Phe Leu Glu Pro Ser Gln Phe Pro  Ser Glu Ser Glu Phe  Leu Lys Asp 
        995                 1000                 1005             


Phe Gly  Asp Leu Lys Xaa Glu  Glu Gln Val Gln Lys  Leu Gln Ala 
    1010                 1015                 1020             


Ile Leu  Lys Pro Met Met Leu  Arg Arg Leu Lys Glu  Asp Val Glu 
    1025                 1030                 1035             


Lys Asn  Leu Ala Pro Lys Gln  Glu Xaa Ile Ile Glu  Val Glu Leu 
    1040                 1045                 1050             


Xaa Asn  Ile Gln Lys Lys Tyr  Tyr Arg Ala Ile Leu  Glu Lys Asn 
    1055                 1060                 1065             


Phe Ser  Phe Leu Ser Lys Gly  Ala Gly His Xaa Asn  Met Pro Asn 
    1070                 1075                 1080             


Leu Leu  Asn Xaa Met Met Glu  Leu Arg Lys Cys Cys  Asn His Pro 
    1085                 1090                 1095             


Tyr Leu  Ile Asn Gly Ala Glu  Glu Lys Ile Leu Xaa  Glu Phe Arg 
    1100                 1105                 1110             


Glu Ala  Cys His Ile Ile Pro  His Asp Phe His Leu  Gln Ala Met 
    1115                 1120                 1125             


Val Arg  Ser Ala Gly Lys Leu  Val Leu Ile Asp Lys  Leu Leu Pro 
    1130                 1135                 1140             


Lys Leu  Lys Ala Gly Gly His  Lys Val Leu Ile Phe  Ser Gln Met 
    1145                 1150                 1155             


Val Arg  Cys Leu Asp Ile Leu  Glu Asp Tyr Leu Ile  Gln Arg Arg 
    1160                 1165                 1170             


Tyr Leu  Tyr Glu Arg Ile Asp  Gly Arg Val Arg Gly  Asn Leu Arg 
    1175                 1180                 1185             


Gln Ala  Ala Ile Asp Arg Phe  Ser Lys Pro Asp Ser  Asp Arg Phe 
    1190                 1195                 1200             


Val Phe  Leu Leu Cys Xaa Arg  Ala Gly Gly Leu Gly  Ile Asn Leu 
    1205                 1210                 1215             


Xaa Ala  Ala Asp Xaa Cys Ile  Ile Phe Asp Ser Asp  Trp Asn Pro 
    1220                 1225                 1230             


Gln Asn  Asp Leu Gln Ala Gln  Ala Arg Cys His Arg  Ile Gly Gln 
    1235                 1240                 1245             


Ser Lys  Ala Val Lys Val Tyr  Arg Leu Ile Xaa Arg  Asn Ser Tyr 
    1250                 1255                 1260             


Glu Arg  Glu Met Phe Asp Lys  Ala Ser Leu Lys Leu  Gly Leu Asp 
    1265                 1270                 1275             


Lys Ala  Val Leu Gln Ser Met  Ser Gly Arg Asp Gly  Asn Ile Xaa 
    1280                 1285                 1290             


Gly Ile  Gln Gln Phe Ser Lys  Lys Glu Ile Glu Asp  Leu Leu Arg 
    1295                 1300                 1305             


Lys Gly  Ala Tyr Ala Ala Ile  Met Glu Glu Asp Asp  Glu Gly Ser 
    1310                 1315                 1320             


Lys Phe  Cys Glu Glu Asp Ile  Asp Gln Ile Leu Leu  Arg Arg Xaa 
    1325                 1330                 1335             


Xaa Xaa  Ile Xaa Ile Glu Ser  Glu Gly Lys Gly Ser  Xaa Phe Ala 
    1340                 1345                 1350             


Lys Ala  Ser Phe Val Ala Ser  Glu Asn Arg Xaa Asp  Ile Ser Leu 
    1355                 1360                 1365             


Asp Asp  Pro Asn Phe Trp Gln  Lys Trp Ala Lys Lys  Ala Asp Leu 
    1370                 1375                 1380             


Asp Met  Asp Leu Leu Asn Ser  Lys Asn Asn Leu Val  Ile Asp Xaa 
    1385                 1390                 1395             


Pro Arg  Val Arg Lys Gln Xaa  Arg His Phe Ser Xaa  Leu Lys Asp 
    1400                 1405                 1410             


Asp Asp  Leu Val Glu Phe Ser  Asp Leu Glu Ser Glu  Asp Asp Glu 
    1415                 1420                 1425             


Arg Pro  Arg Ser Arg Arg His  Asp Arg His His Ala  Tyr Gly Arg 
    1430                 1435                 1440             


Xaa Asp  Cys Phe Arg Val Glu  Lys His Leu Leu Val  Tyr Gly Trp 
    1445                 1450                 1455             


Gly Arg  Trp Arg Asp Ile Leu  Ser His Gly Arg Phe  Lys Arg Arg 
    1460                 1465                 1470             


Met Xaa  Glu Arg Asp Val Glu  Xaa Ile Cys Arg Ala  Ile Leu Val 
    1475                 1480                 1485             


Tyr Cys  Leu Leu His Tyr Arg  Gly Asp Glu Asn Ile  Lys Gly Phe 
    1490                 1495                 1500             


Ile Trp  Asp Leu Ile Ser Pro  Ala Glu Asn Gly Lys  Xaa Lys Glu 
    1505                 1510                 1515             


Leu Gln  Asn His Ser Gly Leu  Ser Ile Pro Val Pro  Arg Gly Arg 
    1520                 1525                 1530             


Lys Gly  Lys Lys Val Lys Ser  Gln Ser Xaa Phe Asp  Ile His Lys 
    1535                 1540                 1545             


Ala Asp  Trp Ile Arg Lys Tyr  Asn Pro Asp Xaa Leu  Phe Gln Asp 
    1550                 1555                 1560             


Glu Ser  Tyr Lys Lys His Leu  Lys His Gln Cys Asn  Lys Val Leu 
    1565                 1570                 1575             


Leu Arg  Val Arg Met Leu Tyr  Tyr Leu Arg Gln Glu  Val Ile Gly 
    1580                 1585                 1590             


Asp Gln  Ala Glu Lys Val Leu  Gly Gly Ala Ile Ala  Ser Glu Ile 
    1595                 1600                 1605             


Asp Ile  Trp Phe Pro Val Val  Asp Gln Leu Glu Val  Pro Xaa Xaa 
    1610                 1615                 1620             


Trp Trp  Asp Ser Glu Ala Asp  Lys Ser Leu Leu Ile  Gly Val Phe 
    1625                 1630                 1635             


Lys His  Gly Tyr Glu Lys Tyr  Asn Xaa Met Arg Ala  Asp Pro Ala 
    1640                 1645                 1650             


Leu Cys  Phe Leu Glu Lys Ala  Gly Arg Pro Asp Asp  Lys Ala Ile 
    1655                 1660                 1665             


Ala Ala  Glu His Arg Val Leu  Asp Asn Phe Ser Asp  Ile Val Glu 
    1670                 1675                 1680             


Gly Val  Asp Phe Asp Lys Asp  Cys Glu Asp Pro Glu  Tyr Lys Pro 
    1685                 1690                 1695             


Leu Gln  Gly Pro Pro Lys Asp  Gln Asp Asp Glu Gly  Asp Pro Leu 
    1700                 1705                 1710             


Met Met  Met Asp Glu Glu Ile  Ser Val Ile Asp Gly  Asp Glu Ala 
    1715                 1720                 1725             


Gln Val  Xaa Gln Gln Pro Gly  His Leu Phe Trp Pro  Pro Gly Ser 
    1730                 1735                 1740             


Ala Leu  Xaa Ala Arg Leu Arg  Arg Leu Val Xaa Ala  Tyr Gln Arg 
    1745                 1750                 1755             


Ser Tyr  Lys Arg Glu Gln Met  Lys Ile Glu Ala Ala  Glu Arg Gly 
    1760                 1765                 1770             


Asp Arg  Arg Arg Arg Arg Cys  Glu Ala Ala Phe Lys  Leu Lys Glu 
    1775                 1780                 1785             


Ile Ala  Arg Arg Glu Lys Gln  Gln Arg Trp Xaa Arg  Arg Glu Gln 
    1790                 1795                 1800             


Xaa Asp  Phe Tyr Arg Val Val  Ser Xaa Phe Gly Val  Glu Tyr Asp 
    1805                 1810                 1815             


Pro Asp  Xaa Met Gln Phe His  Trp Asp Arg Phe Arg  Xaa Phe Ala 
    1820                 1825                 1830             


Arg Leu  Asp Lys Lys Xaa Asp  Glu Ser Leu Xaa Lys  Tyr Phe His 
    1835                 1840                 1845             


Gly Phe  Val Ala Met Cys Arg  Gln Val Cys Arg Leu  Pro Pro Ala 
    1850                 1855                 1860             


Ala Gly  Asp Glu Pro Pro Asp  Pro Asn Leu Phe Ile  Glu Pro Ile 
    1865                 1870                 1875             


Xaa Glu  Glu Arg Ala Ser Arg  Xaa Leu Tyr Arg Ile  Glu Leu Leu 
    1880                 1885                 1890             


Arg Arg  Leu Arg Glu Gln Val  Leu Cys His Pro Leu  Leu Glu Asp 
    1895                 1900                 1905             


Arg Leu  Ala Leu Cys Gln Pro  Pro Gly Pro Glu Leu  Pro Lys Trp 
    1910                 1915                 1920             


Trp Glu  Pro Val Arg His Asp  Gly Glu Leu Leu Arg  Gly Ala Ala 
    1925                 1930                 1935             


Arg His  Gly Val Ser Gln Xaa  Asp Cys Asn Ile Met  Gln Asp Pro 
    1940                 1945                 1950             


Asp Phe  Ser Phe Leu Ala Ala  Arg Met Asn Tyr Met  Gln Asn His 
    1955                 1960                 1965             


Gln Ala  Gly Ala Pro Ala Pro  Ser Leu Ser Arg Cys  Ser Xaa Pro 
    1970                 1975                 1980             


Leu Leu  His Gln Gln Tyr Xaa  Ser Arg Xaa Ala Ser  Pro Leu Pro 
    1985                 1990                 1995             


Leu Arg  Pro Asp Ala Pro Val  Glu Lys Ser Pro Glu  Glu Xaa Ala 
    2000                 2005                 2010             


Xaa Gln  Val Pro Ser Leu Glu  Ser Leu Xaa Leu Lys  Leu Glu His 
    2015                 2020                 2025             


Glu Val  Val Ala Arg Ser Arg  Pro Xaa Pro Gln Asp  Tyr Glu Met 
    2030                 2035                 2040             


Arg Val  Ser Pro Ser Asp Xaa  Xaa Pro Leu Val Ser  Arg Ser Val 
    2045                 2050                 2055             


Pro Pro  Val Lys Leu Glu Asp  Glu Asp Asp Ser Asp  Ser Glu Leu 
    2060                 2065                 2070             


Asp Leu  Ser Lys Leu Ser Pro  Ser Ser Ser Ser Ser  Ser Ser Ser 
    2075                 2080                 2085             


Ser Ser  Ser Ser Ser Ser Xaa  Asp Glu Ser Glu Asp  Glu Lys Glu 
    2090                 2095                 2100             


Glu Lys  Leu Xaa Asp Gln Ser  Arg Ser Lys Leu Tyr  Asp Glu Glu 
    2105                 2110                 2115             


Ser Leu  Leu Ser Leu Xaa Met  Ser Gln Asp Gly Phe  Pro Asn Glu 
    2120                 2125                 2130             


Asp Gly  Glu Gln Met Xaa Pro  Glu Leu Leu Leu Leu  Gln Glu Arg 
    2135                 2140                 2145             


Gln Arg  Ala Ser Glu Trp Pro  Lys Asp Arg Val Leu  Ile Asn Arg 
    2150                 2155                 2160             


Ile Asp  Leu Val Cys Gln Ala  Val Leu Ser Gly Lys  Trp Pro Ser 
    2165                 2170                 2175             


Ser Arg  Arg Ser Gln Glu Met  Val Xaa Gly Gly Ile  Leu Gly Pro 
    2180                 2185                 2190             


Gly Asn  His Leu Leu Asp Ser  Pro Ser Leu Xaa Pro  Gly Glu Tyr 
    2195                 2200                 2205             


Gly Asp  Ser Pro Val Pro Xaa  Pro Arg Ser Ser Ser  Ala Ala Ser 
    2210                 2215                 2220             


Met Ala  Glu Glu Glu Ala Ser  Ala Val Ser Xaa Ala  Ala Ala Gln 
    2225                 2230                 2235             


Phe Xaa  Lys Leu Arg Arg Gly  Met Asp Glu Lys Glu  Phe Xaa Val 
    2240                 2245                 2250             


Gln Ile  Lys Asp Glu Glu Gly  Leu Lys Leu Xaa Phe  Gln Lys His 
    2255                 2260                 2265             


Lys Leu  Met Ala Asn Gly Val  Met Gly Asp Gly His  Pro Leu Phe 
    2270                 2275                 2280             


His Lys  Lys Lys Gly Asn Arg  Lys Lys Leu Val Glu  Leu Glu Val 
    2285                 2290                 2295             


Glu Cys  Met Glu Glu Pro Asn  His Leu Asp Val Asp  Leu Glu Xaa 
    2300                 2305                 2310             


Arg Ile  Pro Val Ile Asn Lys  Val Asp Gly Xaa Leu  Leu Val Gly 
    2315                 2320                 2325             


Glu Asp  Ala Pro Arg Arg Ala  Glu Leu Glu Met Trp  Leu Gln Gly 
    2330                 2335                 2340             


His Pro  Glu Phe Ala Val Asp  Pro Arg Phe Leu Ala  Tyr Met Glu 
    2345                 2350                 2355             


Asp Arg  Arg Lys Gln Lys Trp  Gln Arg Cys Lys Lys  Asn Asn Lys 
    2360                 2365                 2370             


Ala Glu  Leu Asn Cys Leu Gly  Met Glu Pro Val Gln  Xaa Ala Asn 
    2375                 2380                 2385             


Ser Arg  Asn Gly Lys Lys Gly  His His Xaa Glu Xaa  Val Phe Asn 
    2390                 2395                 2400             


Arg Val  Leu Pro Gly Pro Ile  Ala Pro Glu Ser Ser  Lys Lys Arg 
    2405                 2410                 2415             


Ala Arg  Arg Met Arg Pro Asp  Leu Ser Lys Met Met  Ala Leu Met 
    2420                 2425                 2430             


Gln Gly  Gly Ser Xaa Gly Ser  Leu Ser Leu His Asn  Xaa Phe Gln 
    2435                 2440                 2445             


His Ser  Ser Ser Gly Leu Gln  Ser Val Ser Ser Leu  Gly His Ser 
    2450                 2455                 2460             


Ser Ala  Xaa Ser Ala Ser Leu  Pro Phe Met Pro Phe  Val Met Gly 
    2465                 2470                 2475             


Gly Ala  Pro Ser Ser Pro His  Val Asp Ser Ser Xaa  Met Leu His 
    2480                 2485                 2490             


His His  His His His Pro His  Pro His His His His  His His His 
    2495                 2500                 2505             


Pro Gly  Leu Arg Ala Pro Gly  Tyr Pro Ser Ser Pro  Val Xaa Xaa 
    2510                 2515                 2520             


Ala Ser  Gly Xaa Xaa Leu Arg  Leu Pro Pro Leu Gln  Pro Glu Glu 
    2525                 2530                 2535             


Asp Asp  Asp Glu Asp Glu Glu  Asp Asp Asp Asp Leu  Ser Gln Gly 
    2540                 2545                 2550             


Tyr Asp  Ser Ser Glu Arg Asp  Phe Ser Leu Ile Asp  Asp Pro Met 
    2555                 2560                 2565             


Met Pro  Ala Asn Ser Asp Ser  Ser Glu Asp Ala Asp  Asp 
    2570                 2575                 2580     


<210> 6015
<211> 2302
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1119)..(1119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1131)..(1131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1237)..(1237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1280)..(1280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1343)..(1344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1368)..(1368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1452)..(1452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1467)..(1467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1475)..(1475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1520)..(1520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1525)..(1525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1533)..(1533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1552)..(1552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1560)..(1560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1565)..(1565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1600)..(1600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1666)..(1666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1703)..(1703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1711)..(1711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1714)..(1714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1733)..(1733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1735)..(1735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1744)..(1744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1758)..(1758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1771)..(1772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1816)..(1816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1828)..(1828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1845)..(1845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1860)..(1860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1908)..(1908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1925)..(1925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1936)..(1936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1955)..(1955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1961)..(1961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1973)..(1973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1985)..(1985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2034)..(2034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2045)..(2045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2107)..(2107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2119)..(2119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2121)..(2121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2159)..(2159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2167)..(2167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2187)..(2187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2211)..(2211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2243)..(2244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2248)..(2249)
<223> Selenocysteine

<400> 6015
Met Lys Gly Glu Ser Lys Arg Ile Xaa Leu Val Leu Gln Gln Pro Gln 
1               5                   10                  15      


Ser Gly Gly Pro Gln Gly His Arg His Val Val Leu Gly Ser Leu Pro 
            20                  25                  30          


Gly Lys Ile Val Leu Gln Gly Asn Gln Leu Ala Ala Leu Xaa Gln Ala 
        35                  40                  45              


Lys Asn Ala Gln Gly Gln Pro Ala Lys Val Val Xaa Ile Gln Leu Gln 
    50                  55                  60                  


Val Gln Gln Pro Gln Gln Lys Ile Gln Ile Val Pro Gln Pro Pro Ser 
65                  70                  75                  80  


Ser Gln Pro Gln Pro Gln Gln Pro Pro Ser Xaa Gln Pro Val Xaa Leu 
                85                  90                  95      


Ser Ser Val Gln Gln Ala Gln Ile Met Gly Pro Gly Gln Ser Pro Gly 
            100                 105                 110         


Gln Arg Leu Ser Val Pro Val Lys Val Val Leu Gln Pro Gln Ala Gly 
        115                 120                 125             


Ser Ser Gln Gly Ala Ser Ser Gly Leu Ser Val Val Lys Val Leu Ser 
    130                 135                 140                 


Ala Ser Glu Val Ala Ala Leu Ser Ser Pro Ala Ser Ser Ala Pro His 
145                 150                 155                 160 


Ser Gly Gly Lys Xaa Gly Met Glu Glu Asn Arg Arg Leu Glu His Gln 
                165                 170                 175     


Lys Lys Gln Glu Lys Ala Asn Arg Ile Val Ala Glu Ala Ile Ala Arg 
            180                 185                 190         


Ala Arg Ala Arg Gly Glu Gln Asn Ile Pro Arg Val Leu Asn Glu Asp 
        195                 200                 205             


Glu Leu Pro Ser Val Arg Pro Glu Glu Glu Gly Glu Lys Lys Arg Arg 
    210                 215                 220                 


Lys Lys Ser Ala Gly Glu Arg Leu Lys Glu Glu Lys Pro Lys Lys Ser 
225                 230                 235                 240 


Lys Xaa Ser Gly Ala Ser Lys Xaa Lys Gly Lys Ser Lys Leu Asn Xaa 
                245                 250                 255     


Ile Xaa Pro Val Val Gly Lys Lys Arg Lys Arg Asn Xaa Ser Ser Asp 
            260                 265                 270         


Asn Ser Asp Val Glu Val Met Pro Ala Gln Ser Pro Arg Glu Asp Glu 
        275                 280                 285             


Glu Ser Ser Ile Gln Lys Arg Arg Ser Asn Arg Gln Val Lys Arg Lys 
    290                 295                 300                 


Lys Tyr Xaa Glu Asp Leu Asp Ile Lys Ile Xaa Asp Asp Glu Glu Glu 
305                 310                 315                 320 


Glu Glu Val Asp Val Xaa Gly Pro Ile Lys Pro Glu Pro Ile Leu Pro 
                325                 330                 335     


Glu Pro Val Gln Glu Pro Asp Gly Glu Xaa Leu Pro Ser Met Gln Phe 
            340                 345                 350         


Phe Val Glu Asn Pro Ser Glu Glu Asp Ala Ala Ile Val Asp Lys Val 
        355                 360                 365             


Leu Ser Met Arg Ile Val Lys Lys Glu Leu Pro Ser Gly Gln Tyr Xaa 
    370                 375                 380                 


Glu Ala Glu Glu Phe Phe Val Lys Tyr Lys Asn Tyr Ser Tyr Leu His 
385                 390                 395                 400 


Cys Glu Trp Ala Xaa Ile Ser Gln Leu Glu Lys Asp Lys Arg Ile His 
                405                 410                 415     


Gln Lys Leu Lys Arg Phe Lys Xaa Lys Met Ala Gln Met Arg His Phe 
            420                 425                 430         


Phe His Glu Asp Glu Glu Pro Phe Asn Pro Asp Tyr Val Glu Val Asp 
        435                 440                 445             


Arg Ile Leu Asp Glu Ser His Ser Ile Asp Lys Asp Asn Gly Glu Pro 
    450                 455                 460                 


Val Ile Tyr Tyr Leu Val Lys Trp Cys Ser Leu Pro Tyr Glu Asp Ser 
465                 470                 475                 480 


Xaa Trp Glu Leu Lys Glu Asp Val Asp Glu Gly Lys Ile Arg Glu Phe 
                485                 490                 495     


Lys Arg Ile Gln Ser Arg His Pro Glu Leu Lys Arg Val Asn Arg Pro 
            500                 505                 510         


Gln Ala Ser Ala Trp Lys Lys Leu Glu Leu Ser His Glu Tyr Lys Asn 
        515                 520                 525             


Arg Asn Gln Leu Arg Glu Tyr Gln Leu Glu Gly Val Asn Trp Leu Leu 
    530                 535                 540                 


Phe Asn Trp Tyr Asn Arg Gln Asn Cys Ile Leu Ala Asp Glu Met Gly 
545                 550                 555                 560 


Leu Gly Lys Xaa Ile Gln Ser Ile Ala Phe Leu Gln Glu Val Tyr Asn 
                565                 570                 575     


Val Gly Ile His Gly Pro Phe Leu Val Ile Ala Pro Leu Ser Xaa Ile 
            580                 585                 590         


Xaa Asn Trp Glu Arg Glu Phe Asn Xaa Trp Xaa Glu Met Asn Xaa Ile 
        595                 600                 605             


Val Tyr His Gly Ser Leu Ala Ser Arg Gln Met Ile Gln Gln Tyr Glu 
    610                 615                 620                 


Met Tyr Cys Lys Asp Ser Arg Gly Arg Leu Ile Pro Gly Ala Tyr Lys 
625                 630                 635                 640 


Phe Asp Ala Leu Ile Xaa Xaa Phe Glu Met Ile Leu Ser Asp Cys Pro 
                645                 650                 655     


Glu Leu Arg Glu Ile Glu Trp Arg Cys Val Ile Ile Asp Glu Ala His 
            660                 665                 670         


Arg Leu Lys Asn Arg Asn Cys Lys Leu Leu Asp Ser Leu Lys His Met 
        675                 680                 685             


Asp Leu Glu His Lys Val Leu Leu Xaa Gly Xaa Pro Leu Gln Asn Xaa 
    690                 695                 700                 


Val Glu Glu Leu Phe Ser Leu Leu His Phe Leu Glu Pro Ser Gln Phe 
705                 710                 715                 720 


Pro Ser Glu Ser Glu Phe Leu Lys Asp Phe Gly Asp Leu Lys Xaa Glu 
                725                 730                 735     


Glu Gln Val Gln Lys Leu Gln Ala Ile Leu Lys Pro Met Met Leu Arg 
            740                 745                 750         


Arg Leu Lys Glu Asp Val Glu Lys Asn Leu Ala Pro Lys Gln Glu Xaa 
        755                 760                 765             


Ile Ile Glu Val Glu Leu Xaa Asn Ile Gln Lys Lys Tyr Tyr Arg Ala 
    770                 775                 780                 


Ile Leu Glu Lys Asn Phe Ser Phe Leu Ser Lys Gly Ala Gly His Xaa 
785                 790                 795                 800 


Asn Met Pro Asn Leu Leu Asn Xaa Met Met Glu Leu Arg Lys Cys Cys 
                805                 810                 815     


Asn His Pro Tyr Leu Ile Asn Gly Ala Glu Glu Lys Ile Leu Xaa Glu 
            820                 825                 830         


Phe Arg Glu Ala Cys His Ile Ile Pro His Asp Phe His Leu Gln Ala 
        835                 840                 845             


Met Val Arg Ser Ala Gly Lys Leu Val Leu Ile Asp Lys Leu Leu Pro 
    850                 855                 860                 


Lys Leu Lys Ala Gly Gly His Lys Val Leu Ile Phe Ser Gln Met Val 
865                 870                 875                 880 


Arg Cys Leu Asp Ile Leu Glu Asp Tyr Leu Ile Gln Arg Arg Tyr Leu 
                885                 890                 895     


Tyr Glu Arg Ile Asp Gly Arg Val Arg Gly Asn Leu Arg Gln Ala Ala 
            900                 905                 910         


Ile Asp Arg Phe Ser Lys Pro Asp Ser Asp Arg Phe Val Phe Leu Leu 
        915                 920                 925             


Cys Xaa Arg Ala Gly Gly Leu Gly Ile Asn Leu Xaa Ala Ala Asp Xaa 
    930                 935                 940                 


Cys Ile Ile Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu Gln Ala 
945                 950                 955                 960 


Gln Ala Arg Cys His Arg Ile Gly Gln Ser Lys Ala Val Lys Val Tyr 
                965                 970                 975     


Arg Leu Ile Xaa Arg Asn Ser Tyr Glu Arg Glu Met Phe Asp Lys Ala 
            980                 985                 990         


Ser Leu Lys Leu Gly Leu Asp Lys  Ala Val Leu Gln Ser  Met Ser Gly 
        995                 1000                 1005             


Arg Asp  Gly Asn Ile Xaa Gly  Ile Gln Gln Phe Ser  Lys Lys Glu 
    1010                 1015                 1020             


Ile Glu  Asp Leu Leu Arg Lys  Gly Ala Tyr Ala Ala  Ile Met Glu 
    1025                 1030                 1035             


Glu Asp  Asp Glu Gly Ser Lys  Phe Cys Glu Glu Asp  Ile Asp Gln 
    1040                 1045                 1050             


Ile Leu  Leu Arg Arg Xaa Xaa  Xaa Ile Xaa Ile Glu  Ser Glu Gly 
    1055                 1060                 1065             


Lys Gly  Ser Xaa Phe Ala Lys  Ala Ser Phe Val Ala  Ser Glu Asn 
    1070                 1075                 1080             


Arg Xaa  Asp Ile Ser Leu Asp  Asp Pro Asn Phe Trp  Gln Lys Trp 
    1085                 1090                 1095             


Ala Lys  Lys Ala Asp Leu Asp  Met Asp Leu Leu Asn  Ser Lys Asn 
    1100                 1105                 1110             


Asn Leu  Val Ile Asp Xaa Pro  Arg Val Arg Lys Gln  Xaa Arg His 
    1115                 1120                 1125             


Phe Ser  Xaa Leu Lys Asp Asp  Asp Leu Val Glu Phe  Ser Asp Leu 
    1130                 1135                 1140             


Glu Ser  Glu Asp Asp Glu Arg  Pro Arg Ser Arg Arg  His Asp Arg 
    1145                 1150                 1155             


His His  Ala Tyr Gly Arg Xaa  Asp Cys Phe Arg Val  Glu Lys His 
    1160                 1165                 1170             


Leu Leu  Val Tyr Gly Trp Gly  Arg Trp Arg Asp Ile  Leu Ser His 
    1175                 1180                 1185             


Gly Arg  Phe Lys Arg Arg Met  Xaa Glu Arg Asp Val  Glu Xaa Ile 
    1190                 1195                 1200             


Cys Arg  Ala Ile Leu Val Tyr  Cys Leu Leu His Tyr  Arg Gly Asp 
    1205                 1210                 1215             


Glu Asn  Ile Lys Gly Phe Ile  Trp Asp Leu Ile Ser  Pro Ala Glu 
    1220                 1225                 1230             


Asn Gly  Lys Xaa Lys Glu Leu  Gln Asn His Ser Gly  Leu Ser Ile 
    1235                 1240                 1245             


Pro Val  Pro Arg Gly Arg Lys  Gly Lys Lys Val Lys  Ser Gln Ser 
    1250                 1255                 1260             


Xaa Phe  Asp Ile His Lys Ala  Asp Trp Ile Arg Lys  Tyr Asn Pro 
    1265                 1270                 1275             


Asp Xaa  Leu Phe Gln Asp Glu  Ser Tyr Lys Lys His  Leu Lys His 
    1280                 1285                 1290             


Gln Cys  Asn Lys Val Leu Leu  Arg Val Arg Met Leu  Tyr Tyr Leu 
    1295                 1300                 1305             


Arg Gln  Glu Val Ile Gly Asp  Gln Ala Glu Lys Val  Leu Gly Gly 
    1310                 1315                 1320             


Ala Ile  Ala Ser Glu Ile Asp  Ile Trp Phe Pro Val  Val Asp Gln 
    1325                 1330                 1335             


Leu Glu  Val Pro Xaa Xaa Trp  Trp Asp Ser Glu Ala  Asp Lys Ser 
    1340                 1345                 1350             


Leu Leu  Ile Gly Val Phe Lys  His Gly Tyr Glu Lys  Tyr Asn Xaa 
    1355                 1360                 1365             


Met Arg  Ala Asp Pro Ala Leu  Cys Phe Leu Glu Lys  Ala Gly Arg 
    1370                 1375                 1380             


Pro Asp  Asp Lys Ala Ile Ala  Ala Glu His Arg Val  Leu Asp Asn 
    1385                 1390                 1395             


Phe Ser  Asp Ile Val Glu Gly  Val Asp Phe Asp Lys  Asp Cys Glu 
    1400                 1405                 1410             


Asp Pro  Glu Tyr Lys Pro Leu  Gln Gly Pro Pro Lys  Asp Gln Asp 
    1415                 1420                 1425             


Asp Glu  Gly Asp Pro Leu Met  Met Met Asp Glu Glu  Ile Ser Val 
    1430                 1435                 1440             


Ile Asp  Gly Asp Glu Ala Gln  Val Xaa Gln Gln Pro  Gly His Leu 
    1445                 1450                 1455             


Phe Trp  Pro Pro Gly Ser Ala  Leu Xaa Ala Arg Leu  Arg Arg Leu 
    1460                 1465                 1470             


Val Xaa  Ala Tyr Gln Arg Ser  Tyr Lys Arg Glu Gln  Met Lys Ile 
    1475                 1480                 1485             


Glu Ala  Ala Glu Arg Gly Asp  Arg Arg Arg Arg Arg  Cys Glu Ala 
    1490                 1495                 1500             


Ala Phe  Lys Leu Lys Glu Ile  Ala Arg Arg Glu Lys  Gln Gln Arg 
    1505                 1510                 1515             


Trp Xaa  Arg Arg Glu Gln Xaa  Asp Phe Tyr Arg Val  Val Ser Xaa 
    1520                 1525                 1530             


Phe Gly  Val Glu Tyr Asp Pro  Asp Xaa Met Gln Phe  His Trp Asp 
    1535                 1540                 1545             


Arg Phe  Arg Xaa Phe Ala Arg  Leu Asp Lys Lys Xaa  Asp Glu Ser 
    1550                 1555                 1560             


Leu Xaa  Lys Tyr Phe His Gly  Phe Val Ala Met Cys  Arg Gln Val 
    1565                 1570                 1575             


Cys Arg  Leu Pro Pro Ala Ala  Gly Asp Glu Pro Pro  Asp Pro Asn 
    1580                 1585                 1590             


Leu Phe  Ile Glu Pro Ile Xaa  Glu Glu Arg Ala Ser  Arg Xaa Leu 
    1595                 1600                 1605             


Tyr Arg  Ile Glu Leu Leu Arg  Arg Leu Arg Glu Gln  Val Leu Cys 
    1610                 1615                 1620             


His Pro  Leu Leu Glu Asp Arg  Leu Ala Leu Cys Gln  Pro Pro Gly 
    1625                 1630                 1635             


Pro Glu  Leu Pro Lys Trp Trp  Glu Pro Val Arg His  Asp Gly Glu 
    1640                 1645                 1650             


Leu Leu  Arg Gly Ala Ala Arg  His Gly Val Ser Gln  Xaa Asp Cys 
    1655                 1660                 1665             


Asn Ile  Met Gln Asp Pro Asp  Phe Ser Phe Leu Ala  Ala Arg Met 
    1670                 1675                 1680             


Asn Tyr  Met Gln Asn His Gln  Ala Gly Ala Pro Ala  Pro Ser Leu 
    1685                 1690                 1695             


Ser Arg  Cys Ser Xaa Pro Leu  Leu His Gln Gln Tyr  Xaa Ser Arg 
    1700                 1705                 1710             


Xaa Ala  Ser Pro Leu Pro Leu  Arg Pro Asp Ala Pro  Val Glu Lys 
    1715                 1720                 1725             


Ser Pro  Glu Glu Xaa Ala Xaa  Gln Val Pro Ser Leu  Glu Ser Leu 
    1730                 1735                 1740             


Xaa Leu  Lys Leu Glu His Glu  Val Val Ala Arg Ser  Arg Pro Xaa 
    1745                 1750                 1755             


Pro Gln  Asp Tyr Glu Met Arg  Val Ser Pro Ser Asp  Xaa Xaa Pro 
    1760                 1765                 1770             


Leu Val  Ser Arg Ser Val Pro  Pro Val Lys Leu Glu  Asp Glu Asp 
    1775                 1780                 1785             


Asp Ser  Asp Ser Glu Leu Asp  Leu Ser Lys Leu Ser  Pro Ser Ser 
    1790                 1795                 1800             


Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Ser Ser Ser  Xaa Asp Glu 
    1805                 1810                 1815             


Ser Glu  Asp Glu Lys Glu Glu  Lys Leu Xaa Asp Gln  Ser Arg Ser 
    1820                 1825                 1830             


Lys Leu  Tyr Asp Glu Glu Ser  Leu Leu Ser Leu Xaa  Met Ser Gln 
    1835                 1840                 1845             


Asp Gly  Phe Pro Asn Glu Asp  Gly Glu Gln Met Xaa  Pro Glu Leu 
    1850                 1855                 1860             


Leu Leu  Leu Gln Glu Arg Gln  Arg Ala Ser Glu Trp  Pro Lys Asp 
    1865                 1870                 1875             


Arg Val  Leu Ile Asn Arg Ile  Asp Leu Val Cys Gln  Ala Val Leu 
    1880                 1885                 1890             


Ser Gly  Lys Trp Pro Ser Ser  Arg Arg Ser Gln Glu  Met Val Xaa 
    1895                 1900                 1905             


Gly Gly  Ile Leu Gly Pro Gly  Asn His Leu Leu Asp  Ser Pro Ser 
    1910                 1915                 1920             


Leu Xaa  Pro Gly Glu Tyr Gly  Asp Ser Pro Val Pro  Xaa Pro Arg 
    1925                 1930                 1935             


Ser Ser  Ser Ala Ala Ser Met  Ala Glu Glu Glu Ala  Ser Ala Val 
    1940                 1945                 1950             


Ser Xaa  Ala Ala Ala Gln Phe  Xaa Lys Leu Arg Arg  Gly Met Asp 
    1955                 1960                 1965             


Glu Lys  Glu Phe Xaa Val Gln  Ile Lys Asp Glu Glu  Gly Leu Lys 
    1970                 1975                 1980             


Leu Xaa  Phe Gln Lys His Lys  Leu Met Ala Asn Gly  Val Met Gly 
    1985                 1990                 1995             


Asp Gly  His Pro Leu Phe His  Lys Lys Lys Gly Asn  Arg Lys Lys 
    2000                 2005                 2010             


Leu Val  Glu Leu Glu Val Glu  Cys Met Glu Glu Pro  Asn His Leu 
    2015                 2020                 2025             


Asp Val  Asp Leu Glu Xaa Arg  Ile Pro Val Ile Asn  Lys Val Asp 
    2030                 2035                 2040             


Gly Xaa  Leu Leu Val Gly Glu  Asp Ala Pro Arg Arg  Ala Glu Leu 
    2045                 2050                 2055             


Glu Met  Trp Leu Gln Gly His  Pro Glu Phe Ala Val  Asp Pro Arg 
    2060                 2065                 2070             


Phe Leu  Ala Tyr Met Glu Asp  Arg Arg Lys Gln Lys  Trp Gln Arg 
    2075                 2080                 2085             


Cys Lys  Lys Asn Asn Lys Ala  Glu Leu Asn Cys Leu  Gly Met Glu 
    2090                 2095                 2100             


Pro Val  Gln Xaa Ala Asn Ser  Arg Asn Gly Lys Lys  Gly His His 
    2105                 2110                 2115             


Xaa Glu  Xaa Val Phe Asn Arg  Val Leu Pro Gly Pro  Ile Ala Pro 
    2120                 2125                 2130             


Glu Ser  Ser Lys Lys Arg Ala  Arg Arg Met Arg Pro  Asp Leu Ser 
    2135                 2140                 2145             


Lys Met  Met Ala Leu Met Gln  Gly Gly Ser Xaa Gly  Ser Leu Ser 
    2150                 2155                 2160             


Leu His  Asn Xaa Phe Gln His  Ser Ser Ser Gly Leu  Gln Ser Val 
    2165                 2170                 2175             


Ser Ser  Leu Gly His Ser Ser  Ala Xaa Ser Ala Ser  Leu Pro Phe 
    2180                 2185                 2190             


Met Pro  Phe Val Met Gly Gly  Ala Pro Ser Ser Pro  His Val Asp 
    2195                 2200                 2205             


Ser Ser  Xaa Met Leu His His  His His His His Pro  His Pro His 
    2210                 2215                 2220             


His His  His His His His Pro  Gly Leu Arg Ala Pro  Gly Tyr Pro 
    2225                 2230                 2235             


Ser Ser  Pro Val Xaa Xaa Ala  Ser Gly Xaa Xaa Leu  Arg Leu Pro 
    2240                 2245                 2250             


Pro Leu  Gln Pro Glu Glu Asp  Asp Asp Glu Asp Glu  Glu Asp Asp 
    2255                 2260                 2265             


Asp Asp  Leu Ser Gln Gly Tyr  Asp Ser Ser Glu Arg  Asp Phe Ser 
    2270                 2275                 2280             


Leu Ile  Asp Asp Pro Met Met  Pro Ala Asn Ser Asp  Ser Ser Glu 
    2285                 2290                 2295             


Asp Ala  Asp Asp 
    2300         


<210> 6016
<211> 151
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<400> 6016
Met Lys Val Xaa Gln Asp Pro Ile Glu Glu Ala Leu Gly Leu Pro Ser 
1               5                   10                  15      


Ser Leu Asp Ser Leu Asp Gln Met Asn Gln Asp Gly Gly Gly Gly Asp 
            20                  25                  30          


Val Gly Asn Ser Ser Ala Ser Glu Leu Val Pro Pro Pro Glu Glu Xaa 
        35                  40                  45              


Ala Pro Xaa Glu Leu Ser Lys Glu Ser Xaa Ala Pro Ala Pro Glu Ser 
    50                  55                  60                  


Ile Xaa Leu His Asp Tyr Xaa Xaa Gln Pro Ala Ser Gln Glu Gln Pro 
65                  70                  75                  80  


Ala Gln Pro Val Leu Gln Xaa Ser Xaa Pro Xaa Ser Gly Leu Leu Gln 
                85                  90                  95      


Val Ser Lys Ser Gln Glu Ile Leu Ser Gln Gly Asn Pro Phe Met Gly 
            100                 105                 110         


Val Ser Ala Xaa Ala Val Ser Ser Ser Ser Ala Gly Gly Gln Pro Pro 
        115                 120                 125             


Gln Ser Ala Pro Lys Ile Val Ile Leu Lys Ala Pro Pro Ser Ser Ser 
    130                 135                 140                 


Val Xaa Gly Ala His Val Ala 
145                 150     


<210> 6017
<211> 98
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<400> 6017
Met Tyr Leu Ile Ser Ile Leu Gly Ser Pro Val Xaa Arg Asn Leu Pro 
1               5                   10                  15      


Pro Leu Leu Tyr Gly Pro Tyr Trp His Gln Pro Arg Gln Tyr Glu Gln 
            20                  25                  30          


Gly Glu Ser Lys Arg Ile Xaa Leu Val Leu Gln Gln Pro Gln Ser Gly 
        35                  40                  45              


Gly Pro Gln Gly His Arg His Val Val Leu Gly Ser Leu Pro Gly Lys 
    50                  55                  60                  


Ile Val Leu Gln Gly Asn Gln Leu Ala Ala Leu Xaa Gln Ala Lys Asn 
65                  70                  75                  80  


Ala Gln Gly Gln Pro Ala Lys Val Val Xaa Ile Gln Leu Gln Val Gln 
                85                  90                  95      


Gln Pro 
        


<210> 6018
<211> 873
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(857)
<223> Selenocysteine

<400> 6018
Xaa Lys Arg Ile Gln Ser Arg His Pro Glu Leu Lys Arg Val Asn Arg 
1               5                   10                  15      


Pro Gln Ala Ser Ala Trp Lys Lys Leu Glu Leu Ser His Glu Tyr Lys 
            20                  25                  30          


Asn Arg Asn Gln Leu Arg Glu Tyr Gln Leu Glu Gly Val Asn Trp Leu 
        35                  40                  45              


Leu Phe Asn Trp Tyr Asn Arg Gln Asn Cys Ile Leu Ala Asp Glu Met 
    50                  55                  60                  


Gly Leu Gly Lys Xaa Ile Gln Ser Ile Ala Phe Leu Gln Glu Val Tyr 
65                  70                  75                  80  


Asn Val Gly Ile His Gly Pro Phe Leu Val Ile Ala Pro Leu Ser Xaa 
                85                  90                  95      


Ile Xaa Asn Trp Glu Arg Glu Phe Asn Xaa Trp Xaa Glu Met Asn Xaa 
            100                 105                 110         


Ile Val Tyr His Gly Ser Leu Ala Ser Arg Gln Met Ile Gln Gln Tyr 
        115                 120                 125             


Glu Met Tyr Cys Lys Asp Ser Arg Gly Arg Leu Ile Pro Gly Ala Tyr 
    130                 135                 140                 


Lys Phe Asp Ala Leu Ile Xaa Xaa Phe Glu Met Ile Leu Ser Asp Cys 
145                 150                 155                 160 


Pro Glu Leu Arg Glu Ile Glu Trp Arg Cys Val Ile Ile Asp Glu Ala 
                165                 170                 175     


His Arg Leu Lys Asn Arg Asn Cys Lys Leu Leu Asp Ser Leu Lys His 
            180                 185                 190         


Met Asp Leu Glu His Lys Val Leu Leu Xaa Gly Xaa Pro Leu Gln Asn 
        195                 200                 205             


Xaa Val Glu Glu Leu Phe Ser Leu Leu His Phe Leu Glu Pro Ser Gln 
    210                 215                 220                 


Phe Pro Ser Glu Ser Glu Phe Leu Lys Asp Phe Gly Asp Leu Lys Xaa 
225                 230                 235                 240 


Glu Glu Gln Val Gln Lys Leu Gln Ala Ile Leu Lys Pro Met Met Leu 
                245                 250                 255     


Arg Arg Leu Lys Glu Asp Val Glu Lys Asn Leu Ala Pro Lys Gln Glu 
            260                 265                 270         


Xaa Ile Ile Glu Val Glu Leu Xaa Asn Ile Gln Lys Lys Tyr Tyr Arg 
        275                 280                 285             


Ala Ile Leu Glu Lys Asn Phe Ser Phe Leu Ser Lys Gly Ala Gly His 
    290                 295                 300                 


Xaa Asn Met Pro Asn Leu Leu Asn Xaa Met Met Glu Leu Arg Lys Cys 
305                 310                 315                 320 


Cys Asn His Pro Tyr Leu Ile Asn Gly Ala Glu Glu Lys Ile Leu Xaa 
                325                 330                 335     


Glu Phe Arg Glu Ala Cys His Ile Ile Pro His Asp Phe His Leu Gln 
            340                 345                 350         


Ala Met Val Arg Ser Ala Gly Lys Leu Val Leu Ile Asp Lys Leu Leu 
        355                 360                 365             


Pro Lys Leu Lys Ala Gly Gly His Lys Val Leu Ile Phe Ser Gln Met 
    370                 375                 380                 


Val Arg Cys Leu Asp Ile Leu Glu Asp Tyr Leu Ile Gln Arg Arg Tyr 
385                 390                 395                 400 


Leu Tyr Glu Arg Ile Asp Gly Arg Val Arg Gly Asn Leu Arg Gln Ala 
                405                 410                 415     


Ala Ile Asp Arg Phe Ser Lys Pro Asp Ser Asp Arg Phe Val Phe Leu 
            420                 425                 430         


Leu Cys Xaa Arg Ala Gly Gly Leu Gly Ile Asn Leu Xaa Ala Ala Asp 
        435                 440                 445             


Xaa Cys Ile Ile Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu Gln 
    450                 455                 460                 


Ala Gln Ala Arg Cys His Arg Ile Gly Gln Ser Lys Ala Val Lys Val 
465                 470                 475                 480 


Tyr Arg Leu Ile Xaa Arg Asn Ser Tyr Glu Arg Glu Met Phe Asp Lys 
                485                 490                 495     


Ala Ser Leu Lys Leu Gly Leu Asp Lys Ala Val Leu Gln Ser Met Ser 
            500                 505                 510         


Gly Arg Asp Gly Asn Ile Xaa Gly Ile Gln Gln Phe Ser Lys Lys Glu 
        515                 520                 525             


Ile Glu Asp Leu Leu Arg Lys Gly Ala Tyr Ala Ala Ile Met Glu Glu 
    530                 535                 540                 


Asp Asp Glu Gly Ser Lys Phe Cys Glu Glu Asp Ile Asp Gln Ile Leu 
545                 550                 555                 560 


Leu Arg Arg Xaa Xaa Xaa Ile Xaa Ile Glu Ser Glu Gly Lys Gly Ser 
                565                 570                 575     


Xaa Phe Ala Lys Ala Ser Phe Val Ala Ser Glu Asn Arg Xaa Asp Ile 
            580                 585                 590         


Ser Leu Asp Asp Pro Asn Phe Trp Gln Lys Trp Ala Lys Lys Ala Asp 
        595                 600                 605             


Leu Asp Met Asp Leu Leu Asn Ser Lys Asn Asn Leu Val Ile Asp Xaa 
    610                 615                 620                 


Pro Arg Val Arg Lys Gln Xaa Arg His Phe Ser Xaa Leu Lys Asp Asp 
625                 630                 635                 640 


Asp Leu Val Glu Phe Ser Asp Leu Glu Ser Glu Asp Asp Glu Arg Pro 
                645                 650                 655     


Arg Ser Arg Arg His Asp Arg His His Ala Tyr Gly Arg Xaa Asp Cys 
            660                 665                 670         


Phe Arg Val Glu Lys His Leu Leu Val Tyr Gly Trp Gly Arg Trp Arg 
        675                 680                 685             


Asp Ile Leu Ser His Gly Arg Phe Lys Arg Arg Met Xaa Glu Arg Asp 
    690                 695                 700                 


Val Glu Xaa Ile Cys Arg Ala Ile Leu Val Tyr Cys Leu Leu His Tyr 
705                 710                 715                 720 


Arg Gly Asp Glu Asn Ile Lys Gly Phe Ile Trp Asp Leu Ile Ser Pro 
                725                 730                 735     


Ala Glu Asn Gly Lys Xaa Lys Glu Leu Gln Asn His Ser Val Phe Asp 
            740                 745                 750         


Val Ser Pro Phe Pro Gly Leu Ser Ile Pro Val Pro Arg Gly Arg Lys 
        755                 760                 765             


Gly Lys Lys Val Lys Ser Gln Ser Xaa Phe Asp Ile His Lys Ala Asp 
    770                 775                 780                 


Trp Ile Arg Lys Tyr Asn Pro Asp Xaa Leu Phe Gln Asp Glu Ser Tyr 
785                 790                 795                 800 


Lys Lys His Leu Lys His Gln Cys Asn Lys Val Leu Leu Arg Val Arg 
                805                 810                 815     


Met Leu Tyr Tyr Leu Arg Gln Glu Val Ile Gly Asp Gln Ala Glu Lys 
            820                 825                 830         


Val Leu Gly Gly Ala Ile Ala Ser Glu Ile Asp Ile Trp Phe Pro Val 
        835                 840                 845             


Val Asp Gln Leu Glu Val Pro Xaa Xaa Trp Trp Asp Ser Glu Ala Asp 
    850                 855                 860                 


Lys Ser Leu Leu Ile Gly Val Phe Lys 
865                 870             


<210> 6019
<211> 963
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<400> 6019
Met Leu Tyr Tyr Leu Lys Gln Glu Val Ile Gly Asn Glu Cys Gln Lys 
1               5                   10                  15      


Val Phe Asp Gly Val Asp Ala Ser Asp Ile Asp Val Trp Val Pro Glu 
            20                  25                  30          


Pro Asp His Ser Glu Val Pro Ala Glu Trp Trp Asp Phe Asp Ala Asp 
        35                  40                  45              


Lys Ser Leu Leu Ile Gly Val Phe Lys His Gly Tyr Glu Lys Tyr Asn 
    50                  55                  60                  


Xaa Ile Arg Ala Asp Pro Ala Leu Cys Phe Leu Glu Arg Val Gly Lys 
65                  70                  75                  80  


Pro Asp Glu Lys Ala Val Ala Ala Glu Gln Arg Ala Asn Asp Tyr Met 
                85                  90                  95      


Asp Gly Asp Val Glu Asp Pro Glu Tyr Lys Pro Ala Pro Ala Ile Phe 
            100                 105                 110         


Lys Asp Asp Ile Glu Asp Asp Val Ser Ser Pro Gly Asp Leu Val Ile 
        115                 120                 125             


Ala Asp Gly Asp Gly Gln Leu Met Glu Gly Asp Lys Val Tyr Trp Pro 
    130                 135                 140                 


Xaa Gln Ser Ala Leu Xaa Xaa Arg Leu Arg Arg Leu Ile Xaa Ala Tyr 
145                 150                 155                 160 


Gln Arg Xaa Asn Lys Asn Arg Gln Ile Gln Gln Ile Gln Pro Xaa Phe 
                165                 170                 175     


Ser Val Pro Xaa Ser Val Met Gln Pro Ile Tyr Glu Glu Ala Xaa Leu 
            180                 185                 190         


Asn Pro Lys Met Ala Ala Lys Ile Glu Arg Gln Gln Arg Trp Xaa Arg 
        195                 200                 205             


Arg Glu Glu Ala Asp Phe Tyr Arg Val Val Ser Xaa Phe Gly Val Val 
    210                 215                 220                 


Phe Asp Pro Asp Arg Gly Gln Phe Asp Trp Xaa Lys Phe Arg Ala Met 
225                 230                 235                 240 


Ala Arg Leu His Lys Lys Xaa Asp Asp Ser Leu Glu Lys Tyr Leu Tyr 
                245                 250                 255     


Ala Phe Met Ser Met Cys Arg Arg Val Cys Arg Leu Pro Ser Lys Glu 
            260                 265                 270         


Glu Ser Xaa Xaa His Met Lys Ala Tyr Asp Glu Glu Ser Val Ala Ser 
        275                 280                 285             


Leu Ser Xaa Xaa Gln Asp Glu Xaa Gln Asp Ser Phe Gln Met Asn Asn 
    290                 295                 300                 


Gly Xaa Pro Glu Ser Ala Tyr Ile Leu Gln Gly Gly Tyr Met Leu Ala 
305                 310                 315                 320 


Ala Ser Tyr Trp Pro Lys Asp Arg Val Met Ile Asn Arg Leu Asp Ser 
                325                 330                 335     


Ile Cys Gln Xaa Val Leu Lys Gly Lys Trp Pro Ser Ala Arg Arg Ser 
            340                 345                 350         


Tyr Asp Ala Asn Xaa Val Ala Ser Phe Tyr Xaa Xaa Lys Leu Leu Asp 
        355                 360                 365             


Ser Pro Gly Ala Ala Xaa Glu Tyr Ser Asp Pro Ser Val Pro Xaa Pro 
    370                 375                 380                 


Pro Gly Ala Gly Val Lys Glu Glu His Asp Gln Ser Xaa Gln Met Ser 
385                 390                 395                 400 


Lys Val Lys Lys His Val Arg Glu Lys Glu Phe Xaa Val Lys Ile Lys 
                405                 410                 415     


Asp Glu Gly Gly Leu Lys Leu Xaa Phe Gln Lys Gln Gly Leu Ala Gln 
            420                 425                 430         


Lys Arg Pro Phe Asp Gly Glu Asp Gly Ala Leu Gly Gln Gln Gln Tyr 
        435                 440                 445             


Leu Xaa Arg Leu Arg Glu Leu Gln Ser Ala Ser Glu Xaa Ser Leu Val 
    450                 455                 460                 


Asn Phe Pro Lys Ser Ile Pro Val Ser Gly Xaa Ser Ile Gln Pro Xaa 
465                 470                 475                 480 


Leu Gly Ala Asn Gly Val Ile Leu Asp Asn Gln Pro Ile Val Lys Lys 
                485                 490                 495     


Arg Arg Gly Arg Arg Lys Asn Val Glu Gly Val Asp Ile Phe Phe Phe 
            500                 505                 510         


Asn Arg Asn Lys Pro Pro Asn His Val Ser Leu Gly Leu Xaa Ser Ser 
        515                 520                 525             


Gln Ile Ser Xaa Gly Ile Asn Pro Ala Leu Ser Tyr Xaa Gln Pro Gln 
    530                 535                 540                 


Gly Ile Pro Asp Xaa Glu Ser Pro Val Pro Val Ile Asn Leu Lys Asp 
545                 550                 555                 560 


Gly Xaa Arg Leu Ala Gly Asp Asp Ala Pro Lys Arg Lys Asp Leu Glu 
                565                 570                 575     


Lys Trp Leu Lys Glu His Pro Gly Tyr Val Glu Asp Leu Gly Ala Phe 
            580                 585                 590         


Ile Pro Arg Met Gln Leu His Glu Gly Arg Pro Lys Gln Lys Arg His 
        595                 600                 605             


Arg Cys Arg Asn Pro Asn Lys Leu Asp Val Asn Ser Leu Xaa Gly Glu 
    610                 615                 620                 


Glu Arg Val Gln Leu Ile Asn Arg Arg Asn Ala Arg Lys Val Gly Gly 
625                 630                 635                 640 


Ala Phe Ala Pro Pro Leu Lys Asp Leu Cys Arg Phe Leu Lys Glu Asn 
                645                 650                 655     


Ser Glu Tyr Gly Val Ala Pro Glu Trp Gly Asp Val Val Lys Gln Ser 
            660                 665                 670         


Gly Phe Leu Pro Glu Ser Met Tyr Glu Arg Ile Leu Xaa Gly Pro Val 
        675                 680                 685             


Val Arg Glu Glu Val Ser Arg Arg Gly Arg Arg Pro Lys Ser Gly Ile 
    690                 695                 700                 


Ala Lys Ala Xaa Ala Ala Ala Ala Ala Ala Ser Ala Xaa Ser Val Ser 
705                 710                 715                 720 


Gly Asn Pro Leu Leu Ala Asn Gly Leu Leu Pro Gly Val Asp Leu Xaa 
                725                 730                 735     


Xaa Leu Gln Ala Leu Gln Gln Asn Leu Gln Asn Leu Gln Ser Leu Gln 
            740                 745                 750         


Val Xaa Ala Gly Leu Met Gly Met Pro Xaa Gly Leu Pro Ser Gly Gly 
        755                 760                 765             


Glu Ala Lys Asn Met Ala Ala Met Phe Pro Met Leu Leu Ser Gly Met 
    770                 775                 780                 


Ala Gly Leu Pro Asn Leu Leu Gly Met Gly Gly Leu Leu Xaa Lys Pro 
785                 790                 795                 800 


Xaa Glu Ser Gly Xaa Glu Asp Lys Lys Gly Ser Asp Ser Lys Glu Ser 
                805                 810                 815     


Glu Gly Lys Xaa Glu Arg Xaa Glu Ser Gln Ser Ser Glu Asn Gly Gly 
            820                 825                 830         


Glu Asn Ser Val Ser Ser Ser Pro Ser Xaa Ser Ser Xaa Ala Ala Leu 
        835                 840                 845             


Asn Xaa Ala Ala Ala Ala Asn Pro Leu Ala Leu Asn Pro Leu Leu Leu 
    850                 855                 860                 


Ser Asn Ile Leu Tyr Pro Gly Met Leu Leu Xaa Pro Gly Leu Asn Leu 
865                 870                 875                 880 


His Ile Pro Xaa Leu Ser Gln Ser Asn Xaa Phe Asp Val Gln Asn Lys 
                885                 890                 895     


Asn Ser Asp Leu Gly Ser Ser Lys Ser Val Glu Val Lys Glu Glu Asp 
            900                 905                 910         


Ser Arg Ile Lys Asp Gln Glu Asp Lys Gly Gly Xaa Glu Pro Ser Pro 
        915                 920                 925             


Leu Asn Glu Asn Ser Xaa Asp Glu Gly Ser Glu Lys Ala Asp Ala Ser 
    930                 935                 940                 


Ser Gly Ser Asp Ser Xaa Ser Ser Ser Ser Glu Asp Ser Asp Ser Ser 
945                 950                 955                 960 


Asn Glu Asp 
            


<210> 6020
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<400> 6020
Met Ser Glu Lys Lys Gln Arg Lys Lys Val Glu Ser Glu Ser Lys Gln 
1               5                   10                  15      


Glu Lys Ala Asn Arg Ile Ile Ser Glu Ala Ile Ala Lys Ala Lys Glu 
            20                  25                  30          


Arg Gly Glu Arg Asn Ile Pro Arg Val Met Ser Pro Glu Asn Phe Pro 
        35                  40                  45              


Xaa Ala Ser Val Glu Gly Lys Glu Glu Lys Lys Gly Arg Arg Met Lys 
    50                  55                  60                  


Ser Lys Pro Lys Asp Lys Asp Ser Lys Lys Xaa Lys Xaa Cys Ser Lys 
65                  70                  75                  80  


Leu Lys Glu Lys Xaa Lys Ile Gly Lys Leu Ile Ile Xaa Leu Gly Lys 
                85                  90                  95      


Lys Gln Lys Arg Lys Asn Glu Ser Ser Asp Glu Ile Ser Asp Ala Glu 
            100                 105                 110         


Gln Met Pro Gln His Xaa Leu Lys Asp Gln Asp Ser Gln 
        115                 120                 125 


<210> 6021
<211> 1098
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1091)..(1091)
<223> Selenocysteine

<400> 6021
Met Ser Ser Val Lys Arg Pro Arg Gly Arg Pro Pro Ser Ser Lys Lys 
1               5                   10                  15      


Ser Asp Gly Ser Gly Xaa Tyr Xaa Lys Leu Gln Asn Xaa Gln Val Arg 
            20                  25                  30          


Val Met Ser Glu Lys Lys Gln Arg Lys Lys Val Glu Ser Glu Ser Lys 
        35                  40                  45              


Gln Glu Lys Ala Asn Arg Ile Ile Ser Glu Ala Ile Ala Lys Ala Lys 
    50                  55                  60                  


Glu Arg Gly Glu Arg Asn Ile Pro Arg Val Met Ser Pro Glu Asn Phe 
65                  70                  75                  80  


Pro Xaa Ala Ser Val Glu Gly Lys Glu Glu Lys Lys Gly Arg Arg Met 
                85                  90                  95      


Lys Ser Lys Pro Lys Asp Lys Asp Ser Lys Lys Xaa Lys Xaa Cys Ser 
            100                 105                 110         


Lys Leu Lys Glu Lys Xaa Lys Ile Gly Lys Leu Ile Ile Xaa Leu Gly 
        115                 120                 125             


Lys Lys Gln Lys Arg Lys Asn Glu Ser Ser Asp Glu Ile Ser Asp Ala 
    130                 135                 140                 


Glu Gln Met Pro Gln His Xaa Leu Lys Asp Gln Asp Ser Gln Lys Arg 
145                 150                 155                 160 


Arg Ser Asn Arg Gln Ile Lys Arg Lys Lys Tyr Ala Glu Asp Ile Glu 
                165                 170                 175     


Gly Lys Gln Ser Glu Glu Glu Val Lys Gly Ser Met Lys Ile Lys Lys 
            180                 185                 190         


Asn Ser Ala Pro Leu Pro Gly Glu Gln Pro Leu Gln Leu Phe Val Glu 
        195                 200                 205             


Asn Pro Ser Glu Glu Asp Ala Ala Ile Val Asp Lys Ile Leu Ser Ser 
    210                 215                 220                 


Arg Xaa Val Lys Lys Glu Ile Ser Pro Gly Val Met Ile Asp Xaa Glu 
225                 230                 235                 240 


Glu Phe Phe Val Lys Tyr Lys Asn Tyr Ser Tyr Leu His Cys Glu Trp 
                245                 250                 255     


Ala Xaa Glu Glu Gln Leu Leu Lys Asp Lys Arg Ile Gln Gln Lys Ile 
            260                 265                 270         


Lys Arg Phe Lys Leu Arg Gln Ala Gln Arg Ala His Phe Phe Ala Asp 
        275                 280                 285             


Met Glu Glu Glu Pro Phe Asn Pro Asp Tyr Val Glu Val Asp Arg Val 
    290                 295                 300                 


Leu Glu Val Ser Phe Cys Glu Asp Lys Asp Xaa Gly Glu Pro Val Ile 
305                 310                 315                 320 


Tyr Tyr Leu Val Lys Trp Cys Ser Leu Pro Tyr Glu Asp Ser Xaa Trp 
                325                 330                 335     


Glu Leu Lys Glu Asp Val Asp Leu Ala Lys Ile Glu Glu Phe Glu Gln 
            340                 345                 350         


Leu Gln Ala Ser Arg Pro Asp Xaa Arg Arg Leu Asp Arg Pro Pro Ser 
        355                 360                 365             


Asn Ile Trp Lys Lys Ile Asp Gln Ser Arg Asp Tyr Lys Asn Gly Asn 
    370                 375                 380                 


Gln Leu Arg Glu Tyr Gln Leu Glu Gly Leu Asn Trp Leu Leu Phe Asn 
385                 390                 395                 400 


Trp Tyr Asn Arg Arg Asn Cys Ile Leu Ala Asp Glu Met Gly Leu Gly 
                405                 410                 415     


Lys Xaa Ile Gln Ser Ile Xaa Phe Leu Tyr Glu Ile Leu Leu Xaa Gly 
            420                 425                 430         


Ile Arg Gly Pro Phe Leu Ile Ile Ala Pro Leu Ser Xaa Ile Ala Asn 
        435                 440                 445             


Trp Glu Arg Glu Phe Arg Xaa Trp Xaa Asp Ile Asn Val Val Val Tyr 
    450                 455                 460                 


His Gly Ser Leu Ile Ser Arg Gln Met Ile Gln Gln Tyr Glu Met Tyr 
465                 470                 475                 480 


Phe Arg Asp Ser Gln Gly Arg Ile Ile Arg Gly Ala Tyr Arg Phe Gln 
                485                 490                 495     


Ala Ile Ile Xaa Xaa Phe Glu Met Ile Leu Gly Gly Cys Gly Glu Leu 
            500                 505                 510         


Asn Ala Ile Glu Trp Arg Cys Val Ile Ile Asp Glu Ala His Arg Leu 
        515                 520                 525             


Lys Asn Lys Asn Cys Lys Leu Leu Glu Gly Leu Lys Leu Met Asn Leu 
    530                 535                 540                 


Glu His Lys Val Leu Leu Xaa Gly Xaa Pro Leu Gln Asn Xaa Val Glu 
545                 550                 555                 560 


Glu Leu Phe Ser Leu Leu His Phe Leu Glu Pro Leu Arg Phe Pro Ser 
                565                 570                 575     


Glu Ser Xaa Phe Met Gln Glu Phe Gly Asp Leu Lys Xaa Glu Glu Gln 
            580                 585                 590         


Val Gln Lys Leu Gln Ala Ile Leu Lys Pro Met Met Leu Arg Arg Leu 
        595                 600                 605             


Lys Glu Asp Val Glu Lys Lys Leu Ala Pro Lys Glu Glu Xaa Ile Ile 
    610                 615                 620                 


Glu Val Glu Leu Xaa Asn Ile Gln Lys Lys Tyr Tyr Arg Ala Ile Leu 
625                 630                 635                 640 


Glu Lys Asn Phe Ser Phe Leu Ser Lys Gly Ala Gly Gln Xaa Asn Val 
                645                 650                 655     


Pro Asn Leu Val Asn Xaa Met Met Glu Leu Arg Lys Cys Cys Asn His 
            660                 665                 670         


Pro Tyr Leu Ile Lys Gly Ala Glu Glu Lys Ile Leu Gly Glu Phe Arg 
        675                 680                 685             


Asp Xaa Tyr Asn Pro Ala Ala Ser Asp Phe His Leu Gln Ala Met Ile 
    690                 695                 700                 


Gln Ser Ala Gly Lys Leu Val Leu Ile Asp Lys Leu Leu Pro Lys Met 
705                 710                 715                 720 


Lys Ala Gly Gly His Lys Val Leu Ile Phe Ser Gln Met Val Arg Cys 
                725                 730                 735     


Leu Asp Ile Leu Glu Asp Tyr Leu Ile His Lys Arg Tyr Leu Tyr Glu 
            740                 745                 750         


Arg Ile Asp Gly Arg Val Arg Gly Asn Leu Arg Gln Ala Ala Ile Asp 
        755                 760                 765             


Arg Phe Ser Lys Pro Asp Ser Asp Arg Phe Val Phe Leu Leu Cys Xaa 
    770                 775                 780                 


Arg Ala Gly Gly Leu Gly Ile Asn Leu Xaa Ala Ala Asp Xaa Cys Ile 
785                 790                 795                 800 


Ile Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu Gln Ala Gln Ala 
                805                 810                 815     


Arg Cys His Arg Ile Gly Gln Asn Lys Ala Val Lys Val Tyr Arg Leu 
            820                 825                 830         


Val Xaa Arg Asn Ser Tyr Glu Arg Glu Met Phe Asp Arg Ala Ser Leu 
        835                 840                 845             


Lys Leu Gly Leu Asp Lys Ala Val Leu Gln Ser Met Ser Gly Arg Glu 
    850                 855                 860                 


Ser Asn Val Gly Gly Ile Gln Gln Leu Ser Lys Lys Glu Ile Glu Asp 
865                 870                 875                 880 


Leu Leu Arg Arg Gly Ala Tyr Gly Ala Ile Met Glu Glu Glu Asp Glu 
                885                 890                 895     


Gly Ser Lys Phe Cys Glu Glu Asp Ile Asp Gln Ile Leu Leu Arg Arg 
            900                 905                 910         


Xaa Lys Xaa Ile Xaa Ile Glu Ser Glu Gly Arg Gly Ser Xaa Phe Ala 
        915                 920                 925             


Lys Ala Ser Phe Val Ala Ser Gly Asn Arg Xaa Asp Ile Ser Leu Asp 
    930                 935                 940                 


Asp Pro Asn Phe Trp Gln Lys Trp Ala Lys Lys Ala Glu Ile Asp Ile 
945                 950                 955                 960 


Glu Ala Ile Ser Gly Arg Asn Ser Leu Val Ile Asp Xaa Pro Arg Ile 
                965                 970                 975     


Arg Lys Gln Xaa Arg Pro Phe Ser Ala Xaa Lys Asp Glu Leu Ala Glu 
            980                 985                 990         


Leu Ser Glu Ala Glu Ser Glu Gly  Asp Glu Lys Pro Lys  Leu Arg Arg 
        995                 1000                 1005             


Pro Cys  Asp Arg Ser Asn Gly  Tyr Gly Arg Xaa Glu  Cys Phe Arg 
    1010                 1015                 1020             


Val Glu  Lys Asn Leu Leu Val  Tyr Gly Trp Gly Arg  Trp Arg Glu 
    1025                 1030                 1035             


Ile Leu  Ser His Gly Arg Phe  Lys Arg Gln Leu Asn  Glu His Asp 
    1040                 1045                 1050             


Val Glu  Ile Ile Cys Arg Ala  Leu Leu Ala Tyr Cys  Leu Val His 
    1055                 1060                 1065             


Tyr Arg  Gly Asp Glu Lys Ile  Lys Gly Phe Ile Trp  Asp Leu Ile 
    1070                 1075                 1080             


Xaa Pro  Xaa Glu Asp Gly Gln  Xaa Arg Glu Leu Gln  Asn His Leu 
    1085                 1090                 1095             


<210> 6022
<211> 91
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 6022
Met Xaa Asp Pro Met Met Asp Phe Phe Asp Asp Ala Asn Leu Phe Gly 
1               5                   10                  15      


Glu Xaa Leu Glu Glu Glu Asn Leu Leu His Gln Val Glu Ser Gln Xaa 
            20                  25                  30          


Glu Pro Phe Xaa Gly Leu Asp Pro Glu Asp Leu Leu Gln Glu Gly Leu 
        35                  40                  45              


Leu Pro His Phe Asp Glu Ser Xaa Phe Gly Gln Asp Asn Ser Ser His 
    50                  55                  60                  


Ile Leu Asp His Asp Leu Asp Arg Gln Phe Xaa Ser His Leu Val Xaa 
65                  70                  75                  80  


Arg Pro Ser Asp Met Ala Gln Xaa Gln Leu Gln 
                85                  90      


<210> 6023
<211> 53
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<400> 6023
Met Xaa Asp Pro Met Met Asp Phe Phe Asp Asp Ala Asn Leu Phe Gly 
1               5                   10                  15      


Glu Xaa Leu Glu Gly Leu Ser Asp Asp Ala Phe Val Gln Pro Gly Pro 
            20                  25                  30          


Val Ser Leu Val Asp Glu Leu Asn Leu Gly Ala Glu Phe Glu Pro Leu 
        35                  40                  45              


His Ile Asp Ser Leu 
    50              


<210> 6024
<211> 2881
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1103)..(1103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1128)..(1128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1268)..(1268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1272)..(1272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1308)..(1308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1387)..(1387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1391)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1400)..(1400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1413)..(1413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1447)..(1447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1454)..(1454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1460)..(1460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1493)..(1493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1558)..(1558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1560)..(1560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1565)..(1565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1589)..(1589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1591)..(1591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1697)..(1697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1777)..(1777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1782)..(1783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1795)..(1795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1807)..(1807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1812)..(1812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1823)..(1823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1839)..(1839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1852)..(1852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1867)..(1867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1879)..(1879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1917)..(1917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1924)..(1924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1982)..(1982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2011)..(2011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2013)..(2013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2029)..(2029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2069)..(2069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2071)..(2071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2089)..(2089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2100)..(2100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2109)..(2109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2113)..(2113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2182)..(2182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2209)..(2210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2225)..(2226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2230)..(2230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2240)..(2240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2274)..(2274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2291)..(2291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2297)..(2298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2308)..(2308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2317)..(2317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2331)..(2331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2342)..(2342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2368)..(2368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2379)..(2379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2393)..(2393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2398)..(2398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2444)..(2444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2450)..(2450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2459)..(2459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2467)..(2467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2480)..(2480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2540)..(2540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2603)..(2603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2626)..(2626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2635)..(2635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2654)..(2655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2672)..(2672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2680)..(2680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2716)..(2716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2719)..(2719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2723)..(2723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2738)..(2738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2741)..(2741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2760)..(2760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2763)..(2763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2768)..(2768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2793)..(2793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2802)..(2802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2808)..(2808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2842)..(2842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2852)..(2852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2868)..(2868)
<223> Selenocysteine

<400> 6024
Met Xaa Asp Pro Met Met Asp Phe Phe Asp Asp Ala Asn Leu Phe Gly 
1               5                   10                  15      


Glu Xaa Leu Glu Gly Leu Ser Asp Asp Ala Phe Val Gln Pro Gly Pro 
            20                  25                  30          


Val Ser Leu Val Asp Glu Leu Asn Leu Gly Ala Glu Phe Glu Pro Leu 
        35                  40                  45              


His Ile Asp Ser Leu Asn His Val Gln Gly Xaa Pro Xaa His Gln Lys 
    50                  55                  60                  


Met Xaa Asp Phe Glu Gln Leu Asn Gln Phe Asp Ser Ile Lys Phe His 
65                  70                  75                  80  


His Val Asn Gln Ser Phe Gly Ser Pro Ala Glu His Val Leu Ser Pro 
                85                  90                  95      


His Ser Gln Phe Asn Cys Ser Pro Ile His Pro Gln Asn Gln Pro Asn 
            100                 105                 110         


Gly Leu Phe Pro Asp Val Ser Asp Gly Ser Pro Met Trp Gly His Gln 
        115                 120                 125             


Xaa Ala Xaa Xaa Ile Ser Asn Gln Asn Gly Ser Pro Phe His Gln Gln 
    130                 135                 140                 


Gly His Ser His Ser Met His Gln Asn Lys Ser Phe Val Ala His His 
145                 150                 155                 160 


Asp Phe Ala Leu Phe Gln Ala Asn Glu Gln Gln Xaa Gln Cys Xaa Ser 
                165                 170                 175     


Leu Arg Ser Gln Gln Asn Arg Asn Asn Leu Asn Pro Gly Gln Asn Ser 
            180                 185                 190         


Leu Ser Gln Ser Lys Asn Phe Met Asn Val Ser Gly Pro His Arg Val 
        195                 200                 205             


Asn Val Asn His Pro Pro Gln Met Xaa Asn Ala Ser Asn Ser Gln Gln 
    210                 215                 220                 


Ser Ile Ser Met Gln Gln Phe Ser Gln Xaa Ser Asn Pro Ser Ala His 
225                 230                 235                 240 


Phe His Lys Cys Ser Ser His Gln Glu Gly Asn Phe Asn Gly Pro Ser 
                245                 250                 255     


Pro Asn Met Xaa Ser Cys Ser Val Ser Asn Ser Gln Gln Phe Ser Ser 
            260                 265                 270         


His Tyr Ser Phe Ser Ser Asn His Ile Ser Pro Asn Ser Leu Leu Gln 
        275                 280                 285             


Ser Ser Ala Val Leu Ala Ser Asn His Xaa Asn Gln Xaa Leu Ser Asp 
    290                 295                 300                 


Phe Xaa Gly Ser Asn Ser Phe Ser Pro His Arg Gly Ile Lys Gln Glu 
305                 310                 315                 320 


Ser Xaa Gln His Ile Leu Asn Pro Asn Xaa Ser Leu Asn Ser Asn Asn 
                325                 330                 335     


Phe Gln Ile Leu His Ser Ser His Pro Gln Gly Asn Tyr Ser Asn Ser 
            340                 345                 350         


Lys Leu Ser Pro Val His Met Asn Phe Pro Asp Pro Val Asp Ser Gly 
        355                 360                 365             


Xaa Gln Met Gly His Phe Asn Asp His Val Glu Xaa Asn Gly Phe Ser 
    370                 375                 380                 


Ser Leu Glu Glu Asn Leu Leu His Gln Val Glu Ser Gln Xaa Glu Pro 
385                 390                 395                 400 


Phe Xaa Gly Leu Asp Pro Glu Asp Leu Leu Gln Glu Gly Leu Leu Pro 
                405                 410                 415     


His Phe Asp Glu Ser Xaa Phe Gly Gln Asp Asn Ser Ser His Ile Leu 
            420                 425                 430         


Asp His Asp Leu Asp Arg Gln Phe Xaa Ser His Leu Val Xaa Arg Pro 
        435                 440                 445             


Ser Asp Met Ala Gln Xaa Gln Leu Gln Ser Gln Ala Arg Ser Trp His 
    450                 455                 460                 


Ser Ser Phe Ser Asn His Gln His Leu His Asp Arg Asn His Leu Cys 
465                 470                 475                 480 


Leu Gln Arg Gln Pro Pro Ser Ser Lys Lys Ser Asp Gly Ser Gly Xaa 
                485                 490                 495     


Tyr Xaa Lys Leu Gln Asn Xaa Gln Val Arg Val Met Ser Glu Lys Lys 
            500                 505                 510         


Gln Arg Lys Lys Val Glu Ser Glu Ser Lys Gln Glu Lys Ala Asn Arg 
        515                 520                 525             


Ile Ile Ser Glu Ala Ile Ala Lys Ala Lys Glu Arg Gly Glu Arg Asn 
    530                 535                 540                 


Ile Pro Arg Val Met Ser Pro Glu Asn Phe Pro Xaa Ala Ser Val Glu 
545                 550                 555                 560 


Gly Lys Glu Glu Lys Lys Gly Arg Arg Met Lys Ser Lys Pro Lys Asp 
                565                 570                 575     


Lys Asp Ser Lys Lys Xaa Lys Xaa Cys Ser Lys Leu Lys Glu Lys Xaa 
            580                 585                 590         


Lys Ile Gly Lys Leu Ile Ile Xaa Leu Gly Lys Lys Gln Lys Arg Lys 
        595                 600                 605             


Asn Glu Ser Ser Asp Glu Ile Ser Asp Ala Glu Gln Met Pro Gln His 
    610                 615                 620                 


Xaa Leu Lys Asp Gln Asp Ser Gln Lys Arg Arg Ser Asn Arg Gln Ile 
625                 630                 635                 640 


Lys Arg Lys Lys Tyr Ala Glu Asp Ile Glu Gly Lys Gln Ser Glu Glu 
                645                 650                 655     


Glu Val Lys Gly Ser Met Lys Ile Lys Lys Asn Ser Ala Pro Leu Pro 
            660                 665                 670         


Gly Glu Gln Pro Leu Gln Leu Phe Val Glu Asn Pro Ser Glu Glu Asp 
        675                 680                 685             


Ala Ala Ile Val Asp Lys Ile Leu Ser Ser Arg Xaa Val Lys Lys Glu 
    690                 695                 700                 


Ile Ser Pro Gly Val Met Ile Asp Xaa Glu Glu Phe Phe Val Lys Tyr 
705                 710                 715                 720 


Lys Asn Tyr Ser Tyr Leu His Cys Glu Trp Ala Xaa Glu Glu Gln Leu 
                725                 730                 735     


Leu Lys Asp Lys Arg Ile Gln Gln Lys Ile Lys Arg Phe Lys Leu Arg 
            740                 745                 750         


Gln Ala Gln Arg Ala His Phe Phe Ala Asp Met Glu Glu Glu Pro Phe 
        755                 760                 765             


Asn Pro Asp Tyr Val Glu Val Asp Arg Val Leu Glu Val Ser Phe Cys 
    770                 775                 780                 


Glu Asp Lys Asp Xaa Gly Glu Pro Val Ile Tyr Tyr Leu Val Lys Trp 
785                 790                 795                 800 


Cys Ser Leu Pro Tyr Glu Asp Ser Xaa Trp Glu Leu Lys Glu Asp Val 
                805                 810                 815     


Asp Leu Ala Lys Ile Glu Glu Phe Glu Gln Leu Gln Ala Ser Arg Pro 
            820                 825                 830         


Asp Xaa Arg Arg Leu Asp Arg Pro Pro Ser Asn Ile Trp Lys Lys Ile 
        835                 840                 845             


Asp Gln Ser Arg Asp Tyr Lys Asn Gly Asn Gln Leu Arg Glu Tyr Gln 
    850                 855                 860                 


Leu Glu Gly Leu Asn Trp Leu Leu Phe Asn Trp Tyr Asn Arg Arg Asn 
865                 870                 875                 880 


Cys Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Xaa Ile Gln Ser Ile 
                885                 890                 895     


Xaa Phe Leu Tyr Glu Ile Leu Leu Xaa Gly Ile Arg Gly Pro Phe Leu 
            900                 905                 910         


Ile Ile Ala Pro Leu Ser Xaa Ile Ala Asn Trp Glu Arg Glu Phe Arg 
        915                 920                 925             


Xaa Trp Xaa Asp Ile Asn Val Val Val Tyr His Gly Ser Leu Ile Ser 
    930                 935                 940                 


Arg Gln Met Ile Gln Gln Tyr Glu Met Tyr Phe Arg Asp Ser Gln Gly 
945                 950                 955                 960 


Arg Ile Ile Arg Gly Ala Tyr Arg Phe Gln Ala Ile Ile Xaa Xaa Phe 
                965                 970                 975     


Glu Met Ile Leu Gly Gly Cys Gly Glu Leu Asn Ala Ile Glu Trp Arg 
            980                 985                 990         


Cys Val Ile Ile Asp Glu Ala His  Arg Leu Lys Asn Lys  Asn Cys Lys 
        995                 1000                 1005             


Leu Leu  Glu Gly Leu Lys Leu  Met Asn Leu Glu His  Lys Val Leu 
    1010                 1015                 1020             


Leu Xaa  Gly Xaa Pro Leu Gln  Asn Xaa Val Glu Glu  Leu Phe Ser 
    1025                 1030                 1035             


Leu Leu  His Phe Leu Glu Pro  Leu Arg Phe Pro Ser  Glu Ser Xaa 
    1040                 1045                 1050             


Phe Met  Gln Glu Phe Gly Asp  Leu Lys Xaa Glu Glu  Gln Val Gln 
    1055                 1060                 1065             


Lys Leu  Gln Ala Ile Leu Lys  Pro Met Met Leu Arg  Arg Leu Lys 
    1070                 1075                 1080             


Glu Asp  Val Glu Lys Lys Leu  Ala Pro Lys Glu Glu  Xaa Ile Ile 
    1085                 1090                 1095             


Glu Val  Glu Leu Xaa Asn Ile  Gln Lys Lys Tyr Tyr  Arg Ala Ile 
    1100                 1105                 1110             


Leu Glu  Lys Asn Phe Ser Phe  Leu Ser Lys Gly Ala  Gly Gln Xaa 
    1115                 1120                 1125             


Asn Val  Pro Asn Leu Val Asn  Xaa Met Met Glu Leu  Arg Lys Cys 
    1130                 1135                 1140             


Cys Asn  His Pro Tyr Leu Ile  Lys Gly Ala Glu Glu  Lys Ile Leu 
    1145                 1150                 1155             


Gly Glu  Phe Arg Asp Xaa Tyr  Asn Pro Ala Ala Ser  Asp Phe His 
    1160                 1165                 1170             


Leu Gln  Ala Met Ile Gln Ser  Ala Gly Lys Leu Val  Leu Ile Asp 
    1175                 1180                 1185             


Lys Leu  Leu Pro Lys Met Lys  Ala Gly Gly His Lys  Val Leu Ile 
    1190                 1195                 1200             


Phe Ser  Gln Met Val Arg Cys  Leu Asp Ile Leu Glu  Asp Tyr Leu 
    1205                 1210                 1215             


Ile His  Lys Arg Tyr Leu Tyr  Glu Arg Ile Asp Gly  Arg Val Arg 
    1220                 1225                 1230             


Gly Asn  Leu Arg Gln Ala Ala  Ile Asp Arg Phe Ser  Lys Pro Asp 
    1235                 1240                 1245             


Ser Asp  Arg Phe Val Phe Leu  Leu Cys Xaa Arg Ala  Gly Gly Leu 
    1250                 1255                 1260             


Gly Ile  Asn Leu Xaa Ala Ala  Asp Xaa Cys Ile Ile  Phe Asp Ser 
    1265                 1270                 1275             


Asp Trp  Asn Pro Gln Asn Asp  Leu Gln Ala Gln Ala  Arg Cys His 
    1280                 1285                 1290             


Arg Ile  Gly Gln Asn Lys Ala  Val Lys Val Tyr Arg  Leu Val Xaa 
    1295                 1300                 1305             


Arg Asn  Ser Tyr Glu Arg Glu  Met Phe Asp Arg Ala  Ser Leu Lys 
    1310                 1315                 1320             


Leu Gly  Leu Asp Lys Ala Val  Leu Gln Ser Met Ser  Gly Arg Glu 
    1325                 1330                 1335             


Ser Asn  Val Gly Gly Ile Gln  Gln Leu Ser Lys Lys  Glu Ile Glu 
    1340                 1345                 1350             


Asp Leu  Leu Arg Arg Gly Ala  Tyr Gly Ala Ile Met  Glu Glu Glu 
    1355                 1360                 1365             


Asp Glu  Gly Ser Lys Phe Cys  Glu Glu Asp Ile Asp  Gln Ile Leu 
    1370                 1375                 1380             


Leu Arg  Arg Xaa Lys Xaa Ile  Xaa Ile Glu Ser Glu  Gly Arg Gly 
    1385                 1390                 1395             


Ser Xaa  Phe Ala Lys Ala Ser  Phe Val Ala Ser Gly  Asn Arg Xaa 
    1400                 1405                 1410             


Asp Ile  Ser Leu Asp Asp Pro  Asn Phe Trp Gln Lys  Trp Ala Lys 
    1415                 1420                 1425             


Lys Ala  Glu Ile Asp Ile Glu  Ala Ile Ser Gly Arg  Asn Ser Leu 
    1430                 1435                 1440             


Val Ile  Asp Xaa Pro Arg Ile  Arg Lys Gln Xaa Arg  Pro Phe Ser 
    1445                 1450                 1455             


Ala Xaa  Lys Asp Glu Leu Ala  Glu Leu Ser Glu Ala  Glu Ser Glu 
    1460                 1465                 1470             


Gly Asp  Glu Lys Pro Lys Leu  Arg Arg Pro Cys Asp  Arg Ser Asn 
    1475                 1480                 1485             


Gly Tyr  Gly Arg Xaa Glu Cys  Phe Arg Val Glu Lys  Asn Leu Leu 
    1490                 1495                 1500             


Val Tyr  Gly Trp Gly Arg Trp  Arg Glu Ile Leu Ser  His Gly Arg 
    1505                 1510                 1515             


Phe Lys  Arg Gln Leu Asn Glu  His Asp Val Glu Ile  Ile Cys Arg 
    1520                 1525                 1530             


Ala Leu  Leu Ala Tyr Cys Leu  Val His Tyr Arg Gly  Asp Glu Lys 
    1535                 1540                 1545             


Ile Lys  Gly Phe Ile Trp Asp  Leu Ile Xaa Pro Xaa  Glu Asp Gly 
    1550                 1555                 1560             


Gln Xaa  Arg Glu Leu Gln Asn  His Leu Gly Leu Ser  Ala Pro Val 
    1565                 1570                 1575             


Pro Arg  Gly Arg Lys Gly Lys  Lys Val Lys Xaa Gln  Xaa Ser Ser 
    1580                 1585                 1590             


Phe Asp  Ile Gln Lys Ala Glu  Trp Leu Arg Lys Tyr  Asn Pro Glu 
    1595                 1600                 1605             


Gln Leu  Leu Gln Asp Glu Gly  Tyr Lys Lys His Ile  Lys His His 
    1610                 1615                 1620             


Cys Asn  Lys Val Leu Leu Arg  Val Arg Met Leu Tyr  Tyr Leu Lys 
    1625                 1630                 1635             


Gln Glu  Val Ile Gly Asn Glu  Cys Gln Lys Val Phe  Asp Gly Val 
    1640                 1645                 1650             


Asp Ala  Ser Asp Ile Asp Val  Trp Val Pro Glu Pro  Asp His Ser 
    1655                 1660                 1665             


Glu Val  Pro Ala Glu Trp Trp  Asp Phe Asp Ala Asp  Lys Ser Leu 
    1670                 1675                 1680             


Leu Ile  Gly Val Phe Lys His  Gly Tyr Glu Lys Tyr  Asn Xaa Ile 
    1685                 1690                 1695             


Arg Ala  Asp Pro Ala Leu Cys  Phe Leu Glu Arg Val  Gly Lys Pro 
    1700                 1705                 1710             


Asp Glu  Lys Ala Val Ala Ala  Glu Gln Arg Ala Asn  Asp Tyr Met 
    1715                 1720                 1725             


Asp Gly  Asp Val Glu Asp Pro  Glu Tyr Lys Pro Ala  Pro Ala Ile 
    1730                 1735                 1740             


Phe Lys  Asp Asp Ile Glu Asp  Asp Val Ser Ser Pro  Gly Asp Leu 
    1745                 1750                 1755             


Val Ile  Ala Asp Gly Asp Gly  Gln Leu Met Glu Gly  Asp Lys Val 
    1760                 1765                 1770             


Tyr Trp  Pro Xaa Gln Ser Ala  Leu Xaa Xaa Arg Leu  Arg Arg Leu 
    1775                 1780                 1785             


Ile Xaa  Ala Tyr Gln Arg Xaa  Asn Lys Asn Arg Gln  Ile Gln Gln 
    1790                 1795                 1800             


Ile Gln  Pro Xaa Phe Ser Val  Pro Xaa Ser Val Met  Gln Pro Ile 
    1805                 1810                 1815             


Tyr Glu  Glu Ala Xaa Leu Asn  Pro Lys Met Ala Ala  Lys Ile Glu 
    1820                 1825                 1830             


Arg Gln  Gln Arg Trp Xaa Arg  Arg Glu Glu Ala Asp  Phe Tyr Arg 
    1835                 1840                 1845             


Val Val  Ser Xaa Phe Gly Val  Val Phe Asp Pro Asp  Arg Gly Gln 
    1850                 1855                 1860             


Phe Asp  Trp Xaa Lys Phe Arg  Ala Met Ala Arg Leu  His Lys Lys 
    1865                 1870                 1875             


Xaa Asp  Asp Ser Leu Glu Lys  Tyr Leu Tyr Ala Phe  Met Ser Met 
    1880                 1885                 1890             


Cys Arg  Arg Val Cys Arg Leu  Pro Ser Lys Glu Glu  Leu Val Asp 
    1895                 1900                 1905             


Pro Asn  Ile Phe Ile Gln Pro  Ile Xaa Glu Glu Arg  Ala Ser Arg 
    1910                 1915                 1920             


Xaa Leu  Tyr Arg Ile Glu Leu  Leu Arg Lys Val Arg  Glu Gln Ala 
    1925                 1930                 1935             


Leu Arg  His Pro Gln Leu Phe  Glu Arg Leu Lys Leu  Cys His Pro 
    1940                 1945                 1950             


Asn Pro  Asp Leu Pro Val Trp  Trp Glu Cys Gly Pro  His Asp Arg 
    1955                 1960                 1965             


Asp Leu  Leu Ile Gly Ala Ala  Lys His Gly Val Ser  Arg Xaa Asp 
    1970                 1975                 1980             


Tyr His  Ile Leu Arg Asp Pro  Glu Leu Ser Phe Met  Ala Ala Gln 
    1985                 1990                 1995             


Arg Asn  Tyr Ser Gln Ser Lys  Met Ala His Ser Arg  Xaa Ser Xaa 
    2000                 2005                 2010             


Pro Leu  Leu Gln Gln Tyr Gln  Val Ala Leu Ser Ala  Ser Pro Leu 
    2015                 2020                 2025             


Xaa Ser  Leu Pro Arg Leu Leu  Asp Ala Lys Gly Ile  Ile Leu Glu 
    2030                 2035                 2040             


Glu Met  Lys Val Lys Ser Glu  Asn Leu Lys Glu Glu  Pro Gln Ser 
    2045                 2050                 2055             


Ser Glu  Glu Glu Ser Met Ser  Ser Val Glu Xaa Arg  Xaa Leu Ile 
    2060                 2065                 2070             


Lys Ser  Glu Pro Val Ser Pro  Lys Asn Gly Val Leu  Pro Gln Ala 
    2075                 2080                 2085             


Xaa Gly  Asp Gln Lys Ser Gly  Gly Lys Cys Glu Xaa  Asp Arg Arg 
    2090                 2095                 2100             


Met Val  Ala Ala Arg Xaa Glu  Pro Leu Xaa Pro Asn  Pro Ala Ser 
    2105                 2110                 2115             


Lys Lys  Pro Arg Val His Lys  Arg Gly Ser Glu Ser  Ser Ser Asp 
    2120                 2125                 2130             


Ser Asp  Ser Asp Ser Glu Arg  Ser Ser Cys Ser Ser  Arg Ser Ser 
    2135                 2140                 2145             


Ser Ser  Ser Ser Ser Ser Ser  Cys Ser His Ser Arg  Ser Gly Ser 
    2150                 2155                 2160             


Ser Ser  Ser Ser Ser Ser Ser  Cys Ser Ser Ala Ser  Ser Ser Ser 
    2165                 2170                 2175             


Ser Ser  Ser Xaa Ser Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Ser 
    2180                 2185                 2190             


Glu Glu  Ser Asp Ser Asp Glu  Glu Glu Ala Gln Lys  Arg Glu Ser 
    2195                 2200                 2205             


Xaa Xaa  His Met Lys Ala Tyr  Asp Glu Glu Ser Val  Ala Ser Leu 
    2210                 2215                 2220             


Ser Xaa  Xaa Gln Asp Glu Xaa  Gln Asp Ser Phe Gln  Met Asn Asn 
    2225                 2230                 2235             


Gly Xaa  Pro Glu Ser Ala Tyr  Ile Leu Gln Gly Gly  Tyr Met Leu 
    2240                 2245                 2250             


Ala Ala  Ser Tyr Trp Pro Lys  Asp Arg Val Met Ile  Asn Arg Leu 
    2255                 2260                 2265             


Asp Ser  Ile Cys Gln Xaa Val  Leu Lys Gly Lys Trp  Pro Ser Ala 
    2270                 2275                 2280             


Arg Arg  Ser Tyr Asp Ala Asn  Xaa Val Ala Ser Phe  Tyr Xaa Xaa 
    2285                 2290                 2295             


Lys Leu  Leu Asp Ser Pro Gly  Ala Ala Xaa Glu Tyr  Ser Asp Pro 
    2300                 2305                 2310             


Ser Val  Pro Xaa Pro Pro Gly  Ala Gly Val Lys Glu  Glu His Asp 
    2315                 2320                 2325             


Gln Ser  Xaa Gln Met Ser Lys  Glu Gly Gly Leu Lys  Leu Xaa Phe 
    2330                 2335                 2340             


Gln Lys  Gln Gly Leu Ala Gln  Lys Arg Pro Phe Asp  Gly Glu Asp 
    2345                 2350                 2355             


Gly Ala  Leu Gly Gln Gln Gln  Tyr Leu Xaa Arg Leu  Arg Glu Leu 
    2360                 2365                 2370             


Gln Ser  Ala Ser Glu Xaa Ser  Leu Val Asn Phe Pro  Lys Ser Ile 
    2375                 2380                 2385             


Pro Val  Ser Gly Xaa Ser Ile  Gln Pro Xaa Leu Gly  Ala Asn Gly 
    2390                 2395                 2400             


Val Ile  Leu Asp Asn Gln Pro  Ile Val Lys Lys Arg  Arg Gly Arg 
    2405                 2410                 2415             


Arg Lys  Asn Val Glu Gly Val  Asp Ile Phe Phe Phe  Asn Arg Asn 
    2420                 2425                 2430             


Lys Pro  Pro Asn His Val Ser  Leu Gly Leu Xaa Ser  Ser Gln Ile 
    2435                 2440                 2445             


Ser Xaa  Gly Ile Asn Pro Ala  Leu Ser Tyr Xaa Gln  Pro Gln Gly 
    2450                 2455                 2460             


Ile Pro  Asp Xaa Glu Ser Pro  Val Pro Val Ile Asn  Leu Lys Asp 
    2465                 2470                 2475             


Gly Xaa  Arg Leu Ala Gly Asp  Asp Ala Pro Lys Arg  Lys Asp Leu 
    2480                 2485                 2490             


Glu Lys  Trp Leu Lys Glu His  Pro Gly Tyr Val Glu  Asp Leu Gly 
    2495                 2500                 2505             


Ala Phe  Ile Pro Arg Met Gln  Leu His Glu Gly Arg  Pro Lys Gln 
    2510                 2515                 2520             


Lys Arg  His Arg Cys Arg Asn  Pro Asn Lys Leu Asp  Val Asn Ser 
    2525                 2530                 2535             


Leu Xaa  Gly Glu Glu Arg Val  Gln Leu Ile Asn Arg  Arg Asn Ala 
    2540                 2545                 2550             


Arg Lys  Val Gly Gly Ala Phe  Ala Pro Pro Leu Lys  Asp Leu Cys 
    2555                 2560                 2565             


Arg Phe  Leu Lys Glu Asn Ser  Glu Tyr Gly Val Ala  Pro Glu Trp 
    2570                 2575                 2580             


Gly Asp  Val Val Lys Gln Ser  Gly Phe Leu Pro Glu  Ser Met Tyr 
    2585                 2590                 2595             


Glu Arg  Ile Leu Xaa Gly Pro  Val Val Arg Glu Glu  Val Ser Arg 
    2600                 2605                 2610             


Arg Gly  Arg Arg Pro Lys Ser  Gly Ile Ala Lys Ala  Xaa Ala Ala 
    2615                 2620                 2625             


Ala Ala  Ala Ala Ser Ala Xaa  Ser Val Ser Gly Asn  Pro Leu Leu 
    2630                 2635                 2640             


Ala Asn  Gly Leu Leu Pro Gly  Val Asp Leu Xaa Xaa  Leu Gln Ala 
    2645                 2650                 2655             


Leu Gln  Gln Asn Leu Gln Asn  Leu Gln Ser Leu Gln  Val Xaa Ala 
    2660                 2665                 2670             


Gly Leu  Met Gly Met Pro Xaa  Gly Leu Pro Ser Gly  Gly Glu Ala 
    2675                 2680                 2685             


Lys Asn  Met Ala Ala Met Phe  Pro Met Leu Leu Ser  Gly Met Ala 
    2690                 2695                 2700             


Gly Leu  Pro Asn Leu Leu Gly  Met Gly Gly Leu Leu  Xaa Lys Pro 
    2705                 2710                 2715             


Xaa Glu  Ser Gly Xaa Glu Asp  Lys Lys Gly Ser Asp  Ser Lys Glu 
    2720                 2725                 2730             


Ser Glu  Gly Lys Xaa Glu Arg  Xaa Glu Ser Gln Ser  Ser Glu Asn 
    2735                 2740                 2745             


Gly Gly  Glu Asn Ser Val Ser  Ser Ser Pro Ser Xaa  Ser Ser Xaa 
    2750                 2755                 2760             


Ala Ala  Leu Asn Xaa Ala Ala  Ala Ala Asn Pro Leu  Ala Leu Asn 
    2765                 2770                 2775             


Pro Leu  Leu Leu Ser Asn Ile  Leu Tyr Pro Gly Met  Leu Leu Xaa 
    2780                 2785                 2790             


Pro Gly  Leu Asn Leu His Ile  Pro Xaa Leu Ser Gln  Ser Asn Xaa 
    2795                 2800                 2805             


Phe Asp  Val Gln Asn Lys Asn  Ser Asp Leu Gly Ser  Ser Lys Ser 
    2810                 2815                 2820             


Val Glu  Val Lys Glu Glu Asp  Ser Arg Ile Lys Asp  Gln Glu Asp 
    2825                 2830                 2835             


Lys Gly  Gly Xaa Glu Pro Ser  Pro Leu Asn Glu Asn  Ser Xaa Asp 
    2840                 2845                 2850             


Glu Gly  Ser Glu Lys Ala Asp  Ala Ser Ser Gly Ser  Asp Ser Xaa 
    2855                 2860                 2865             


Ser Ser  Ser Ser Glu Asp Ser  Asp Ser Ser Asn Glu  Asp 
    2870                 2875                 2880     


<210> 6025
<211> 2897
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1103)..(1103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1128)..(1128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1268)..(1268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1272)..(1272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1308)..(1308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1387)..(1387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1391)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1400)..(1400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1413)..(1413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1447)..(1447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1454)..(1454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1460)..(1460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1493)..(1493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1558)..(1558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1560)..(1560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1565)..(1565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1589)..(1589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1591)..(1591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1697)..(1697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1777)..(1777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1782)..(1783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1795)..(1795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1807)..(1807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1812)..(1812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1823)..(1823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1839)..(1839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1852)..(1852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1867)..(1867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1879)..(1879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1917)..(1917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1924)..(1924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1982)..(1982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2011)..(2011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2013)..(2013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2029)..(2029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2069)..(2069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2071)..(2071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2089)..(2089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2100)..(2100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2109)..(2109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2113)..(2113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2182)..(2182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2209)..(2210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2225)..(2226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2230)..(2230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2240)..(2240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2274)..(2274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2291)..(2291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2297)..(2298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2308)..(2308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2317)..(2317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2331)..(2331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2346)..(2346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2358)..(2358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2384)..(2384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2395)..(2395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2409)..(2409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2414)..(2414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2460)..(2460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2466)..(2466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2475)..(2475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2483)..(2483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2496)..(2496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2556)..(2556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2619)..(2619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2642)..(2642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2651)..(2651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2670)..(2671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2688)..(2688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2696)..(2696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2732)..(2732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2735)..(2735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2739)..(2739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2754)..(2754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2757)..(2757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2776)..(2776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2779)..(2779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2784)..(2784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2809)..(2809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2818)..(2818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2824)..(2824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2858)..(2858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2868)..(2868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2884)..(2884)
<223> Selenocysteine

<400> 6025
Met Xaa Asp Pro Met Met Asp Phe Phe Asp Asp Ala Asn Leu Phe Gly 
1               5                   10                  15      


Glu Xaa Leu Glu Gly Leu Ser Asp Asp Ala Phe Val Gln Pro Gly Pro 
            20                  25                  30          


Val Ser Leu Val Asp Glu Leu Asn Leu Gly Ala Glu Phe Glu Pro Leu 
        35                  40                  45              


His Ile Asp Ser Leu Asn His Val Gln Gly Xaa Pro Xaa His Gln Lys 
    50                  55                  60                  


Met Xaa Asp Phe Glu Gln Leu Asn Gln Phe Asp Ser Ile Lys Phe His 
65                  70                  75                  80  


His Val Asn Gln Ser Phe Gly Ser Pro Ala Glu His Val Leu Ser Pro 
                85                  90                  95      


His Ser Gln Phe Asn Cys Ser Pro Ile His Pro Gln Asn Gln Pro Asn 
            100                 105                 110         


Gly Leu Phe Pro Asp Val Ser Asp Gly Ser Pro Met Trp Gly His Gln 
        115                 120                 125             


Xaa Ala Xaa Xaa Ile Ser Asn Gln Asn Gly Ser Pro Phe His Gln Gln 
    130                 135                 140                 


Gly His Ser His Ser Met His Gln Asn Lys Ser Phe Val Ala His His 
145                 150                 155                 160 


Asp Phe Ala Leu Phe Gln Ala Asn Glu Gln Gln Xaa Gln Cys Xaa Ser 
                165                 170                 175     


Leu Arg Ser Gln Gln Asn Arg Asn Asn Leu Asn Pro Gly Gln Asn Ser 
            180                 185                 190         


Leu Ser Gln Ser Lys Asn Phe Met Asn Val Ser Gly Pro His Arg Val 
        195                 200                 205             


Asn Val Asn His Pro Pro Gln Met Xaa Asn Ala Ser Asn Ser Gln Gln 
    210                 215                 220                 


Ser Ile Ser Met Gln Gln Phe Ser Gln Xaa Ser Asn Pro Ser Ala His 
225                 230                 235                 240 


Phe His Lys Cys Ser Ser His Gln Glu Gly Asn Phe Asn Gly Pro Ser 
                245                 250                 255     


Pro Asn Met Xaa Ser Cys Ser Val Ser Asn Ser Gln Gln Phe Ser Ser 
            260                 265                 270         


His Tyr Ser Phe Ser Ser Asn His Ile Ser Pro Asn Ser Leu Leu Gln 
        275                 280                 285             


Ser Ser Ala Val Leu Ala Ser Asn His Xaa Asn Gln Xaa Leu Ser Asp 
    290                 295                 300                 


Phe Xaa Gly Ser Asn Ser Phe Ser Pro His Arg Gly Ile Lys Gln Glu 
305                 310                 315                 320 


Ser Xaa Gln His Ile Leu Asn Pro Asn Xaa Ser Leu Asn Ser Asn Asn 
                325                 330                 335     


Phe Gln Ile Leu His Ser Ser His Pro Gln Gly Asn Tyr Ser Asn Ser 
            340                 345                 350         


Lys Leu Ser Pro Val His Met Asn Phe Pro Asp Pro Val Asp Ser Gly 
        355                 360                 365             


Xaa Gln Met Gly His Phe Asn Asp His Val Glu Xaa Asn Gly Phe Ser 
    370                 375                 380                 


Ser Leu Glu Glu Asn Leu Leu His Gln Val Glu Ser Gln Xaa Glu Pro 
385                 390                 395                 400 


Phe Xaa Gly Leu Asp Pro Glu Asp Leu Leu Gln Glu Gly Leu Leu Pro 
                405                 410                 415     


His Phe Asp Glu Ser Xaa Phe Gly Gln Asp Asn Ser Ser His Ile Leu 
            420                 425                 430         


Asp His Asp Leu Asp Arg Gln Phe Xaa Ser His Leu Val Xaa Arg Pro 
        435                 440                 445             


Ser Asp Met Ala Gln Xaa Gln Leu Gln Ser Gln Ala Arg Ser Trp His 
    450                 455                 460                 


Ser Ser Phe Ser Asn His Gln His Leu His Asp Arg Asn His Leu Cys 
465                 470                 475                 480 


Leu Gln Arg Gln Pro Pro Ser Ser Lys Lys Ser Asp Gly Ser Gly Xaa 
                485                 490                 495     


Tyr Xaa Lys Leu Gln Asn Xaa Gln Val Arg Val Met Ser Glu Lys Lys 
            500                 505                 510         


Gln Arg Lys Lys Val Glu Ser Glu Ser Lys Gln Glu Lys Ala Asn Arg 
        515                 520                 525             


Ile Ile Ser Glu Ala Ile Ala Lys Ala Lys Glu Arg Gly Glu Arg Asn 
    530                 535                 540                 


Ile Pro Arg Val Met Ser Pro Glu Asn Phe Pro Xaa Ala Ser Val Glu 
545                 550                 555                 560 


Gly Lys Glu Glu Lys Lys Gly Arg Arg Met Lys Ser Lys Pro Lys Asp 
                565                 570                 575     


Lys Asp Ser Lys Lys Xaa Lys Xaa Cys Ser Lys Leu Lys Glu Lys Xaa 
            580                 585                 590         


Lys Ile Gly Lys Leu Ile Ile Xaa Leu Gly Lys Lys Gln Lys Arg Lys 
        595                 600                 605             


Asn Glu Ser Ser Asp Glu Ile Ser Asp Ala Glu Gln Met Pro Gln His 
    610                 615                 620                 


Xaa Leu Lys Asp Gln Asp Ser Gln Lys Arg Arg Ser Asn Arg Gln Ile 
625                 630                 635                 640 


Lys Arg Lys Lys Tyr Ala Glu Asp Ile Glu Gly Lys Gln Ser Glu Glu 
                645                 650                 655     


Glu Val Lys Gly Ser Met Lys Ile Lys Lys Asn Ser Ala Pro Leu Pro 
            660                 665                 670         


Gly Glu Gln Pro Leu Gln Leu Phe Val Glu Asn Pro Ser Glu Glu Asp 
        675                 680                 685             


Ala Ala Ile Val Asp Lys Ile Leu Ser Ser Arg Xaa Val Lys Lys Glu 
    690                 695                 700                 


Ile Ser Pro Gly Val Met Ile Asp Xaa Glu Glu Phe Phe Val Lys Tyr 
705                 710                 715                 720 


Lys Asn Tyr Ser Tyr Leu His Cys Glu Trp Ala Xaa Glu Glu Gln Leu 
                725                 730                 735     


Leu Lys Asp Lys Arg Ile Gln Gln Lys Ile Lys Arg Phe Lys Leu Arg 
            740                 745                 750         


Gln Ala Gln Arg Ala His Phe Phe Ala Asp Met Glu Glu Glu Pro Phe 
        755                 760                 765             


Asn Pro Asp Tyr Val Glu Val Asp Arg Val Leu Glu Val Ser Phe Cys 
    770                 775                 780                 


Glu Asp Lys Asp Xaa Gly Glu Pro Val Ile Tyr Tyr Leu Val Lys Trp 
785                 790                 795                 800 


Cys Ser Leu Pro Tyr Glu Asp Ser Xaa Trp Glu Leu Lys Glu Asp Val 
                805                 810                 815     


Asp Leu Ala Lys Ile Glu Glu Phe Glu Gln Leu Gln Ala Ser Arg Pro 
            820                 825                 830         


Asp Xaa Arg Arg Leu Asp Arg Pro Pro Ser Asn Ile Trp Lys Lys Ile 
        835                 840                 845             


Asp Gln Ser Arg Asp Tyr Lys Asn Gly Asn Gln Leu Arg Glu Tyr Gln 
    850                 855                 860                 


Leu Glu Gly Leu Asn Trp Leu Leu Phe Asn Trp Tyr Asn Arg Arg Asn 
865                 870                 875                 880 


Cys Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Xaa Ile Gln Ser Ile 
                885                 890                 895     


Xaa Phe Leu Tyr Glu Ile Leu Leu Xaa Gly Ile Arg Gly Pro Phe Leu 
            900                 905                 910         


Ile Ile Ala Pro Leu Ser Xaa Ile Ala Asn Trp Glu Arg Glu Phe Arg 
        915                 920                 925             


Xaa Trp Xaa Asp Ile Asn Val Val Val Tyr His Gly Ser Leu Ile Ser 
    930                 935                 940                 


Arg Gln Met Ile Gln Gln Tyr Glu Met Tyr Phe Arg Asp Ser Gln Gly 
945                 950                 955                 960 


Arg Ile Ile Arg Gly Ala Tyr Arg Phe Gln Ala Ile Ile Xaa Xaa Phe 
                965                 970                 975     


Glu Met Ile Leu Gly Gly Cys Gly Glu Leu Asn Ala Ile Glu Trp Arg 
            980                 985                 990         


Cys Val Ile Ile Asp Glu Ala His  Arg Leu Lys Asn Lys  Asn Cys Lys 
        995                 1000                 1005             


Leu Leu  Glu Gly Leu Lys Leu  Met Asn Leu Glu His  Lys Val Leu 
    1010                 1015                 1020             


Leu Xaa  Gly Xaa Pro Leu Gln  Asn Xaa Val Glu Glu  Leu Phe Ser 
    1025                 1030                 1035             


Leu Leu  His Phe Leu Glu Pro  Leu Arg Phe Pro Ser  Glu Ser Xaa 
    1040                 1045                 1050             


Phe Met  Gln Glu Phe Gly Asp  Leu Lys Xaa Glu Glu  Gln Val Gln 
    1055                 1060                 1065             


Lys Leu  Gln Ala Ile Leu Lys  Pro Met Met Leu Arg  Arg Leu Lys 
    1070                 1075                 1080             


Glu Asp  Val Glu Lys Lys Leu  Ala Pro Lys Glu Glu  Xaa Ile Ile 
    1085                 1090                 1095             


Glu Val  Glu Leu Xaa Asn Ile  Gln Lys Lys Tyr Tyr  Arg Ala Ile 
    1100                 1105                 1110             


Leu Glu  Lys Asn Phe Ser Phe  Leu Ser Lys Gly Ala  Gly Gln Xaa 
    1115                 1120                 1125             


Asn Val  Pro Asn Leu Val Asn  Xaa Met Met Glu Leu  Arg Lys Cys 
    1130                 1135                 1140             


Cys Asn  His Pro Tyr Leu Ile  Lys Gly Ala Glu Glu  Lys Ile Leu 
    1145                 1150                 1155             


Gly Glu  Phe Arg Asp Xaa Tyr  Asn Pro Ala Ala Ser  Asp Phe His 
    1160                 1165                 1170             


Leu Gln  Ala Met Ile Gln Ser  Ala Gly Lys Leu Val  Leu Ile Asp 
    1175                 1180                 1185             


Lys Leu  Leu Pro Lys Met Lys  Ala Gly Gly His Lys  Val Leu Ile 
    1190                 1195                 1200             


Phe Ser  Gln Met Val Arg Cys  Leu Asp Ile Leu Glu  Asp Tyr Leu 
    1205                 1210                 1215             


Ile His  Lys Arg Tyr Leu Tyr  Glu Arg Ile Asp Gly  Arg Val Arg 
    1220                 1225                 1230             


Gly Asn  Leu Arg Gln Ala Ala  Ile Asp Arg Phe Ser  Lys Pro Asp 
    1235                 1240                 1245             


Ser Asp  Arg Phe Val Phe Leu  Leu Cys Xaa Arg Ala  Gly Gly Leu 
    1250                 1255                 1260             


Gly Ile  Asn Leu Xaa Ala Ala  Asp Xaa Cys Ile Ile  Phe Asp Ser 
    1265                 1270                 1275             


Asp Trp  Asn Pro Gln Asn Asp  Leu Gln Ala Gln Ala  Arg Cys His 
    1280                 1285                 1290             


Arg Ile  Gly Gln Asn Lys Ala  Val Lys Val Tyr Arg  Leu Val Xaa 
    1295                 1300                 1305             


Arg Asn  Ser Tyr Glu Arg Glu  Met Phe Asp Arg Ala  Ser Leu Lys 
    1310                 1315                 1320             


Leu Gly  Leu Asp Lys Ala Val  Leu Gln Ser Met Ser  Gly Arg Glu 
    1325                 1330                 1335             


Ser Asn  Val Gly Gly Ile Gln  Gln Leu Ser Lys Lys  Glu Ile Glu 
    1340                 1345                 1350             


Asp Leu  Leu Arg Arg Gly Ala  Tyr Gly Ala Ile Met  Glu Glu Glu 
    1355                 1360                 1365             


Asp Glu  Gly Ser Lys Phe Cys  Glu Glu Asp Ile Asp  Gln Ile Leu 
    1370                 1375                 1380             


Leu Arg  Arg Xaa Lys Xaa Ile  Xaa Ile Glu Ser Glu  Gly Arg Gly 
    1385                 1390                 1395             


Ser Xaa  Phe Ala Lys Ala Ser  Phe Val Ala Ser Gly  Asn Arg Xaa 
    1400                 1405                 1410             


Asp Ile  Ser Leu Asp Asp Pro  Asn Phe Trp Gln Lys  Trp Ala Lys 
    1415                 1420                 1425             


Lys Ala  Glu Ile Asp Ile Glu  Ala Ile Ser Gly Arg  Asn Ser Leu 
    1430                 1435                 1440             


Val Ile  Asp Xaa Pro Arg Ile  Arg Lys Gln Xaa Arg  Pro Phe Ser 
    1445                 1450                 1455             


Ala Xaa  Lys Asp Glu Leu Ala  Glu Leu Ser Glu Ala  Glu Ser Glu 
    1460                 1465                 1470             


Gly Asp  Glu Lys Pro Lys Leu  Arg Arg Pro Cys Asp  Arg Ser Asn 
    1475                 1480                 1485             


Gly Tyr  Gly Arg Xaa Glu Cys  Phe Arg Val Glu Lys  Asn Leu Leu 
    1490                 1495                 1500             


Val Tyr  Gly Trp Gly Arg Trp  Arg Glu Ile Leu Ser  His Gly Arg 
    1505                 1510                 1515             


Phe Lys  Arg Gln Leu Asn Glu  His Asp Val Glu Ile  Ile Cys Arg 
    1520                 1525                 1530             


Ala Leu  Leu Ala Tyr Cys Leu  Val His Tyr Arg Gly  Asp Glu Lys 
    1535                 1540                 1545             


Ile Lys  Gly Phe Ile Trp Asp  Leu Ile Xaa Pro Xaa  Glu Asp Gly 
    1550                 1555                 1560             


Gln Xaa  Arg Glu Leu Gln Asn  His Leu Gly Leu Ser  Ala Pro Val 
    1565                 1570                 1575             


Pro Arg  Gly Arg Lys Gly Lys  Lys Val Lys Xaa Gln  Xaa Ser Ser 
    1580                 1585                 1590             


Phe Asp  Ile Gln Lys Ala Glu  Trp Leu Arg Lys Tyr  Asn Pro Glu 
    1595                 1600                 1605             


Gln Leu  Leu Gln Asp Glu Gly  Tyr Lys Lys His Ile  Lys His His 
    1610                 1615                 1620             


Cys Asn  Lys Val Leu Leu Arg  Val Arg Met Leu Tyr  Tyr Leu Lys 
    1625                 1630                 1635             


Gln Glu  Val Ile Gly Asn Glu  Cys Gln Lys Val Phe  Asp Gly Val 
    1640                 1645                 1650             


Asp Ala  Ser Asp Ile Asp Val  Trp Val Pro Glu Pro  Asp His Ser 
    1655                 1660                 1665             


Glu Val  Pro Ala Glu Trp Trp  Asp Phe Asp Ala Asp  Lys Ser Leu 
    1670                 1675                 1680             


Leu Ile  Gly Val Phe Lys His  Gly Tyr Glu Lys Tyr  Asn Xaa Ile 
    1685                 1690                 1695             


Arg Ala  Asp Pro Ala Leu Cys  Phe Leu Glu Arg Val  Gly Lys Pro 
    1700                 1705                 1710             


Asp Glu  Lys Ala Val Ala Ala  Glu Gln Arg Ala Asn  Asp Tyr Met 
    1715                 1720                 1725             


Asp Gly  Asp Val Glu Asp Pro  Glu Tyr Lys Pro Ala  Pro Ala Ile 
    1730                 1735                 1740             


Phe Lys  Asp Asp Ile Glu Asp  Asp Val Ser Ser Pro  Gly Asp Leu 
    1745                 1750                 1755             


Val Ile  Ala Asp Gly Asp Gly  Gln Leu Met Glu Gly  Asp Lys Val 
    1760                 1765                 1770             


Tyr Trp  Pro Xaa Gln Ser Ala  Leu Xaa Xaa Arg Leu  Arg Arg Leu 
    1775                 1780                 1785             


Ile Xaa  Ala Tyr Gln Arg Xaa  Asn Lys Asn Arg Gln  Ile Gln Gln 
    1790                 1795                 1800             


Ile Gln  Pro Xaa Phe Ser Val  Pro Xaa Ser Val Met  Gln Pro Ile 
    1805                 1810                 1815             


Tyr Glu  Glu Ala Xaa Leu Asn  Pro Lys Met Ala Ala  Lys Ile Glu 
    1820                 1825                 1830             


Arg Gln  Gln Arg Trp Xaa Arg  Arg Glu Glu Ala Asp  Phe Tyr Arg 
    1835                 1840                 1845             


Val Val  Ser Xaa Phe Gly Val  Val Phe Asp Pro Asp  Arg Gly Gln 
    1850                 1855                 1860             


Phe Asp  Trp Xaa Lys Phe Arg  Ala Met Ala Arg Leu  His Lys Lys 
    1865                 1870                 1875             


Xaa Asp  Asp Ser Leu Glu Lys  Tyr Leu Tyr Ala Phe  Met Ser Met 
    1880                 1885                 1890             


Cys Arg  Arg Val Cys Arg Leu  Pro Ser Lys Glu Glu  Leu Val Asp 
    1895                 1900                 1905             


Pro Asn  Ile Phe Ile Gln Pro  Ile Xaa Glu Glu Arg  Ala Ser Arg 
    1910                 1915                 1920             


Xaa Leu  Tyr Arg Ile Glu Leu  Leu Arg Lys Val Arg  Glu Gln Ala 
    1925                 1930                 1935             


Leu Arg  His Pro Gln Leu Phe  Glu Arg Leu Lys Leu  Cys His Pro 
    1940                 1945                 1950             


Asn Pro  Asp Leu Pro Val Trp  Trp Glu Cys Gly Pro  His Asp Arg 
    1955                 1960                 1965             


Asp Leu  Leu Ile Gly Ala Ala  Lys His Gly Val Ser  Arg Xaa Asp 
    1970                 1975                 1980             


Tyr His  Ile Leu Arg Asp Pro  Glu Leu Ser Phe Met  Ala Ala Gln 
    1985                 1990                 1995             


Arg Asn  Tyr Ser Gln Ser Lys  Met Ala His Ser Arg  Xaa Ser Xaa 
    2000                 2005                 2010             


Pro Leu  Leu Gln Gln Tyr Gln  Val Ala Leu Ser Ala  Ser Pro Leu 
    2015                 2020                 2025             


Xaa Ser  Leu Pro Arg Leu Leu  Asp Ala Lys Gly Ile  Ile Leu Glu 
    2030                 2035                 2040             


Glu Met  Lys Val Lys Ser Glu  Asn Leu Lys Glu Glu  Pro Gln Ser 
    2045                 2050                 2055             


Ser Glu  Glu Glu Ser Met Ser  Ser Val Glu Xaa Arg  Xaa Leu Ile 
    2060                 2065                 2070             


Lys Ser  Glu Pro Val Ser Pro  Lys Asn Gly Val Leu  Pro Gln Ala 
    2075                 2080                 2085             


Xaa Gly  Asp Gln Lys Ser Gly  Gly Lys Cys Glu Xaa  Asp Arg Arg 
    2090                 2095                 2100             


Met Val  Ala Ala Arg Xaa Glu  Pro Leu Xaa Pro Asn  Pro Ala Ser 
    2105                 2110                 2115             


Lys Lys  Pro Arg Val His Lys  Arg Gly Ser Glu Ser  Ser Ser Asp 
    2120                 2125                 2130             


Ser Asp  Ser Asp Ser Glu Arg  Ser Ser Cys Ser Ser  Arg Ser Ser 
    2135                 2140                 2145             


Ser Ser  Ser Ser Ser Ser Ser  Cys Ser His Ser Arg  Ser Gly Ser 
    2150                 2155                 2160             


Ser Ser  Ser Ser Ser Ser Ser  Cys Ser Ser Ala Ser  Ser Ser Ser 
    2165                 2170                 2175             


Ser Ser  Ser Xaa Ser Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Ser 
    2180                 2185                 2190             


Glu Glu  Ser Asp Ser Asp Glu  Glu Glu Ala Gln Lys  Arg Glu Ser 
    2195                 2200                 2205             


Xaa Xaa  His Met Lys Ala Tyr  Asp Glu Glu Ser Val  Ala Ser Leu 
    2210                 2215                 2220             


Ser Xaa  Xaa Gln Asp Glu Xaa  Gln Asp Ser Phe Gln  Met Asn Asn 
    2225                 2230                 2235             


Gly Xaa  Pro Glu Ser Ala Tyr  Ile Leu Gln Gly Gly  Tyr Met Leu 
    2240                 2245                 2250             


Ala Ala  Ser Tyr Trp Pro Lys  Asp Arg Val Met Ile  Asn Arg Leu 
    2255                 2260                 2265             


Asp Ser  Ile Cys Gln Xaa Val  Leu Lys Gly Lys Trp  Pro Ser Ala 
    2270                 2275                 2280             


Arg Arg  Ser Tyr Asp Ala Asn  Xaa Val Ala Ser Phe  Tyr Xaa Xaa 
    2285                 2290                 2295             


Lys Leu  Leu Asp Ser Pro Gly  Ala Ala Xaa Glu Tyr  Ser Asp Pro 
    2300                 2305                 2310             


Ser Val  Pro Xaa Pro Pro Gly  Ala Gly Val Lys Glu  Glu His Asp 
    2315                 2320                 2325             


Gln Ser  Xaa Gln Met Ser Lys  Val Lys Lys His Val  Arg Glu Lys 
    2330                 2335                 2340             


Glu Phe  Xaa Val Lys Ile Lys  Asp Glu Gly Gly Leu  Lys Leu Xaa 
    2345                 2350                 2355             


Phe Gln  Lys Gln Gly Leu Ala  Gln Lys Arg Pro Phe  Asp Gly Glu 
    2360                 2365                 2370             


Asp Gly  Ala Leu Gly Gln Gln  Gln Tyr Leu Xaa Arg  Leu Arg Glu 
    2375                 2380                 2385             


Leu Gln  Ser Ala Ser Glu Xaa  Ser Leu Val Asn Phe  Pro Lys Ser 
    2390                 2395                 2400             


Ile Pro  Val Ser Gly Xaa Ser  Ile Gln Pro Xaa Leu  Gly Ala Asn 
    2405                 2410                 2415             


Gly Val  Ile Leu Asp Asn Gln  Pro Ile Val Lys Lys  Arg Arg Gly 
    2420                 2425                 2430             


Arg Arg  Lys Asn Val Glu Gly  Val Asp Ile Phe Phe  Phe Asn Arg 
    2435                 2440                 2445             


Asn Lys  Pro Pro Asn His Val  Ser Leu Gly Leu Xaa  Ser Ser Gln 
    2450                 2455                 2460             


Ile Ser  Xaa Gly Ile Asn Pro  Ala Leu Ser Tyr Xaa  Gln Pro Gln 
    2465                 2470                 2475             


Gly Ile  Pro Asp Xaa Glu Ser  Pro Val Pro Val Ile  Asn Leu Lys 
    2480                 2485                 2490             


Asp Gly  Xaa Arg Leu Ala Gly  Asp Asp Ala Pro Lys  Arg Lys Asp 
    2495                 2500                 2505             


Leu Glu  Lys Trp Leu Lys Glu  His Pro Gly Tyr Val  Glu Asp Leu 
    2510                 2515                 2520             


Gly Ala  Phe Ile Pro Arg Met  Gln Leu His Glu Gly  Arg Pro Lys 
    2525                 2530                 2535             


Gln Lys  Arg His Arg Cys Arg  Asn Pro Asn Lys Leu  Asp Val Asn 
    2540                 2545                 2550             


Ser Leu  Xaa Gly Glu Glu Arg  Val Gln Leu Ile Asn  Arg Arg Asn 
    2555                 2560                 2565             


Ala Arg  Lys Val Gly Gly Ala  Phe Ala Pro Pro Leu  Lys Asp Leu 
    2570                 2575                 2580             


Cys Arg  Phe Leu Lys Glu Asn  Ser Glu Tyr Gly Val  Ala Pro Glu 
    2585                 2590                 2595             


Trp Gly  Asp Val Val Lys Gln  Ser Gly Phe Leu Pro  Glu Ser Met 
    2600                 2605                 2610             


Tyr Glu  Arg Ile Leu Xaa Gly  Pro Val Val Arg Glu  Glu Val Ser 
    2615                 2620                 2625             


Arg Arg  Gly Arg Arg Pro Lys  Ser Gly Ile Ala Lys  Ala Xaa Ala 
    2630                 2635                 2640             


Ala Ala  Ala Ala Ala Ser Ala  Xaa Ser Val Ser Gly  Asn Pro Leu 
    2645                 2650                 2655             


Leu Ala  Asn Gly Leu Leu Pro  Gly Val Asp Leu Xaa  Xaa Leu Gln 
    2660                 2665                 2670             


Ala Leu  Gln Gln Asn Leu Gln  Asn Leu Gln Ser Leu  Gln Val Xaa 
    2675                 2680                 2685             


Ala Gly  Leu Met Gly Met Pro  Xaa Gly Leu Pro Ser  Gly Gly Glu 
    2690                 2695                 2700             


Ala Lys  Asn Met Ala Ala Met  Phe Pro Met Leu Leu  Ser Gly Met 
    2705                 2710                 2715             


Ala Gly  Leu Pro Asn Leu Leu  Gly Met Gly Gly Leu  Leu Xaa Lys 
    2720                 2725                 2730             


Pro Xaa  Glu Ser Gly Xaa Glu  Asp Lys Lys Gly Ser  Asp Ser Lys 
    2735                 2740                 2745             


Glu Ser  Glu Gly Lys Xaa Glu  Arg Xaa Glu Ser Gln  Ser Ser Glu 
    2750                 2755                 2760             


Asn Gly  Gly Glu Asn Ser Val  Ser Ser Ser Pro Ser  Xaa Ser Ser 
    2765                 2770                 2775             


Xaa Ala  Ala Leu Asn Xaa Ala  Ala Ala Ala Asn Pro  Leu Ala Leu 
    2780                 2785                 2790             


Asn Pro  Leu Leu Leu Ser Asn  Ile Leu Tyr Pro Gly  Met Leu Leu 
    2795                 2800                 2805             


Xaa Pro  Gly Leu Asn Leu His  Ile Pro Xaa Leu Ser  Gln Ser Asn 
    2810                 2815                 2820             


Xaa Phe  Asp Val Gln Asn Lys  Asn Ser Asp Leu Gly  Ser Ser Lys 
    2825                 2830                 2835             


Ser Val  Glu Val Lys Glu Glu  Asp Ser Arg Ile Lys  Asp Gln Glu 
    2840                 2845                 2850             


Asp Lys  Gly Gly Xaa Glu Pro  Ser Pro Leu Asn Glu  Asn Ser Xaa 
    2855                 2860                 2865             


Asp Glu  Gly Ser Glu Lys Ala  Asp Ala Ser Ser Gly  Ser Asp Ser 
    2870                 2875                 2880             


Xaa Ser  Ser Ser Ser Glu Asp  Ser Asp Ser Ser Asn  Glu Asp 
    2885                 2890                 2895         


<210> 6026
<211> 632
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<400> 6026
Met Xaa Asp Pro Met Met Asp Phe Phe Asp Asp Ala Asn Leu Phe Gly 
1               5                   10                  15      


Glu Xaa Leu Glu Gly Leu Ser Asp Asp Ala Phe Val Gln Pro Gly Pro 
            20                  25                  30          


Val Ser Leu Val Asp Glu Leu Asn Leu Gly Ala Glu Phe Glu Pro Leu 
        35                  40                  45              


His Ile Asp Ser Leu Asn His Val Gln Gly Xaa Pro Xaa His Gln Lys 
    50                  55                  60                  


Met Xaa Asp Phe Glu Gln Leu Asn Gln Phe Asp Ser Ile Lys Phe His 
65                  70                  75                  80  


His Val Asn Gln Ser Phe Gly Ser Pro Ala Glu His Val Leu Ser Pro 
                85                  90                  95      


His Ser Gln Phe Asn Cys Ser Pro Ile His Pro Gln Asn Gln Pro Asn 
            100                 105                 110         


Gly Leu Phe Pro Asp Val Ser Asp Gly Ser Pro Met Trp Gly His Gln 
        115                 120                 125             


Xaa Ala Xaa Xaa Ile Ser Asn Gln Asn Gly Ser Pro Phe His Gln Gln 
    130                 135                 140                 


Gly His Ser His Ser Met His Gln Asn Lys Ser Phe Val Ala His His 
145                 150                 155                 160 


Asp Phe Ala Leu Phe Gln Ala Asn Glu Gln Gln Xaa Gln Cys Xaa Ser 
                165                 170                 175     


Leu Arg Ser Gln Gln Asn Arg Asn Asn Leu Asn Pro Gly Gln Asn Ser 
            180                 185                 190         


Leu Ser Gln Ser Lys Asn Phe Met Asn Val Ser Gly Pro His Arg Val 
        195                 200                 205             


Asn Val Asn His Pro Pro Gln Met Xaa Asn Ala Ser Asn Ser Gln Gln 
    210                 215                 220                 


Ser Ile Ser Met Gln Gln Phe Ser Gln Xaa Ser Asn Pro Ser Ala His 
225                 230                 235                 240 


Phe His Lys Cys Ser Ser His Gln Glu Gly Asn Phe Asn Gly Pro Ser 
                245                 250                 255     


Pro Asn Met Xaa Ser Cys Ser Val Ser Asn Ser Gln Gln Phe Ser Ser 
            260                 265                 270         


His Tyr Ser Phe Ser Ser Asn His Ile Ser Pro Asn Ser Leu Leu Gln 
        275                 280                 285             


Ser Ser Ala Val Leu Ala Ser Asn His Xaa Asn Gln Xaa Leu Ser Asp 
    290                 295                 300                 


Phe Xaa Gly Ser Asn Ser Phe Ser Pro His Arg Gly Ile Lys Gln Glu 
305                 310                 315                 320 


Ser Xaa Gln His Ile Leu Asn Pro Asn Xaa Ser Leu Asn Ser Asn Asn 
                325                 330                 335     


Phe Gln Ile Leu His Ser Ser His Pro Gln Gly Asn Tyr Ser Asn Ser 
            340                 345                 350         


Lys Leu Ser Pro Val His Met Asn Phe Pro Asp Pro Val Asp Ser Gly 
        355                 360                 365             


Xaa Gln Met Gly His Phe Asn Asp His Val Glu Xaa Asn Gly Phe Ser 
    370                 375                 380                 


Ser Leu Glu Glu Asn Leu Leu His Gln Val Glu Ser Gln Xaa Glu Pro 
385                 390                 395                 400 


Phe Xaa Gly Leu Asp Pro Glu Asp Leu Leu Gln Glu Gly Leu Leu Pro 
                405                 410                 415     


His Phe Asp Glu Ser Xaa Phe Gly Gln Asp Asn Ser Ser His Ile Leu 
            420                 425                 430         


Asp His Asp Leu Asp Arg Gln Phe Xaa Ser His Leu Val Xaa Arg Pro 
        435                 440                 445             


Ser Asp Met Ala Gln Xaa Gln Leu Gln Ser Gln Ala Arg Ser Trp His 
    450                 455                 460                 


Ser Ser Phe Ser Asn His Gln His Leu His Asp Arg Asn His Leu Cys 
465                 470                 475                 480 


Leu Gln Arg Gln Pro Pro Ser Ser Lys Lys Ser Asp Gly Ser Gly Xaa 
                485                 490                 495     


Tyr Xaa Lys Leu Gln Asn Xaa Gln Val Arg Val Met Ser Glu Lys Lys 
            500                 505                 510         


Gln Arg Lys Lys Val Glu Ser Glu Ser Lys Gln Glu Lys Ala Asn Arg 
        515                 520                 525             


Ile Ile Ser Glu Ala Ile Ala Lys Ala Lys Glu Arg Gly Glu Arg Asn 
    530                 535                 540                 


Ile Pro Arg Val Met Ser Pro Glu Asn Phe Pro Xaa Ala Ser Val Glu 
545                 550                 555                 560 


Gly Lys Glu Glu Lys Lys Gly Arg Arg Met Lys Ser Lys Pro Lys Asp 
                565                 570                 575     


Lys Asp Ser Lys Lys Xaa Lys Xaa Cys Ser Lys Leu Lys Glu Lys Xaa 
            580                 585                 590         


Lys Ile Gly Lys Leu Ile Ile Xaa Leu Gly Lys Lys Gln Lys Arg Lys 
        595                 600                 605             


Asn Glu Ser Ser Asp Glu Ile Ser Asp Ala Glu Gln Met Pro Gln His 
    610                 615                 620                 


Xaa Leu Lys Asp Gln Asp Ser Gln 
625                 630         


<210> 6027
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 6027
Xaa Pro Ala Leu Ser Tyr Xaa Gln Pro Gln Gly Ile Pro Asp Xaa Glu 
1               5                   10                  15      


Ser Pro Val Pro Val Ile Asn Leu Lys Asp Gly Xaa Arg Leu Ala Gly 
            20                  25                  30          


Asp Asp Ala Pro Lys Arg Lys Asp Leu Glu Lys Trp Leu Lys Glu His 
        35                  40                  45              


Pro Gly Tyr Val Glu Asp Leu Gly Ala Phe Ile Pro Arg Met Gln Leu 
    50                  55                  60                  


His Glu Gly Arg Pro Lys Gln Lys Arg His Arg Cys Arg Asn Pro Asn 
65                  70                  75                  80  


Lys Leu Asp Val Asn Ser Leu Xaa Gly Glu Glu Arg Val Gln Leu Ile 
                85                  90                  95      


Asn Arg Arg Asn Ala Arg Lys Ile Arg Lys Leu Arg Leu Lys Glu Ile 
            100                 105                 110         


Tyr 
    


<210> 6028
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<400> 6028
Xaa Pro Asn His Val Ser Leu Gly Leu Xaa Ser Ser Gln Ile Ser Xaa 
1               5                   10                  15      


Gly Ile Asn Pro Ala Leu Ser Tyr Xaa Gln Pro Gln Gly Ile Pro Asp 
            20                  25                  30          


Xaa Glu Ser Pro Val Pro Val Ile Asn Leu Lys Asp Gly Xaa Arg Leu 
        35                  40                  45              


Ala Gly Asp Asp Ala Pro Lys Arg Lys Asp Leu Glu Lys Trp Leu Lys 
    50                  55                  60                  


Glu His Pro Gly Tyr Val Glu Asp Leu Gly Ala Phe Ile Pro Arg Met 
65                  70                  75                  80  


Gln Leu His Glu Gly Arg Pro Lys Gln Lys Arg His Arg Cys Arg Asn 
                85                  90                  95      


Pro Asn Lys Leu Asp Val Asn Ser Leu Xaa Gly Glu Glu Arg Val Gln 
            100                 105                 110         


Leu Ile Asn Arg Arg Asn Ala Arg Lys Ala 
        115                 120         


<210> 6029
<211> 89
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 6029
Lys Ser Tyr Gln Cys Leu Lys Glu Xaa Cys Glu Lys Leu Gly Tyr Gln 
1               5                   10                  15      


Trp Lys Lys Ser Cys Met Asn Gln Val Xaa Ile Ser Xaa Xaa Asp Arg 
            20                  25                  30          


Arg Asn Asn Lys Leu Ile Phe Lys Val Asn Leu Leu Glu Met Asp Asp 
        35                  40                  45              


Lys Ile Leu Val Asp Phe Arg Leu Ser Lys Gly Asp Gly Leu Glu Phe 
    50                  55                  60                  


Lys Arg His Phe Leu Lys Ile Lys Gly Lys Leu Ile Asp Ile Val Ser 
65                  70                  75                  80  


Ser Gln Lys Ile Trp Leu Pro Ala Xaa 
                85                  


<210> 6030
<211> 192
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<400> 6030
Met Ala Val Pro Phe Val Glu Asp Trp Asp Leu Val Gln Xaa Leu Gly 
1               5                   10                  15      


Glu Glu Pro Asp Ile Gly Met Pro Glu Pro Asp Ala Gln Arg Phe Phe 
            20                  25                  30          


His Gln Leu Met Ala Gly Val Val Tyr Leu His Gly Ile Gly Ile Xaa 
        35                  40                  45              


His Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Asp Glu Arg Asp Asn 
    50                  55                  60                  


Leu Lys Ile Ser Asp Phe Gly Leu Ala Xaa Val Phe Arg Tyr Asn Asn 
65                  70                  75                  80  


Arg Glu Arg Leu Leu Asn Lys Met Cys Gly Xaa Leu Pro Tyr Val Ala 
                85                  90                  95      


Pro Glu Leu Leu Lys Arg Arg Glu Phe His Ala Glu Pro Val Asp Val 
            100                 105                 110         


Trp Ser Cys Gly Ile Val Leu Xaa Ala Met Leu Ala Gly Glu Leu Pro 
        115                 120                 125             


Trp Asp Gln Pro Ser Asp Ser Cys Gln Glu Tyr Ser Asp Trp Lys Glu 
    130                 135                 140                 


Lys Lys Xaa Tyr Leu Asn Pro Trp Lys Lys Ile Asp Ser Ala Pro Leu 
145                 150                 155                 160 


Ala Leu Leu His Lys Ile Leu Val Glu Asn Pro Ser Ala Arg Ile Xaa 
                165                 170                 175     


Ile Pro Asp Ile Lys Lys Asp Arg Trp Tyr Asn Lys Pro Leu Lys Lys 
            180                 185                 190         


<210> 6031
<211> 42
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<400> 6031
Met Ala Val Pro Phe Val Glu Asp Trp Asp Leu Val Gln Xaa Leu Gly 
1               5                   10                  15      


Glu Gly Ala Tyr Gly Glu Val Gln Leu Ala Val Asn Arg Val Xaa Glu 
            20                  25                  30          


Glu Ala Val Ala Val Lys Ile Val Asp Met 
        35                  40          


<210> 6032
<211> 127
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 6032
Met Ala Val Pro Phe Val Glu Asp Trp Asp Leu Val Gln Xaa Leu Gly 
1               5                   10                  15      


Glu Gly Ala Tyr Gly Glu Val Gln Leu Ala Val Asn Arg Val Xaa Glu 
            20                  25                  30          


Glu Ala Val Ala Val Lys Ile Val Asp Met Lys Arg Ala Val Asp Cys 
        35                  40                  45              


Pro Glu Asn Ile Lys Lys Glu Ile Cys Ile Asn Lys Met Leu Asn His 
    50                  55                  60                  


Glu Asn Val Val Lys Phe Tyr Gly His Arg Arg Glu Gly Asn Ile Gln 
65                  70                  75                  80  


Tyr Leu Phe Leu Glu Tyr Cys Ser Gly Gly Glu Leu Phe Asp Arg Ile 
                85                  90                  95      


Glu Pro Asp Ile Gly Met Pro Glu Pro Asp Ala Gln Arg Phe Phe His 
            100                 105                 110         


Gln Leu Met Ala Gly Val Val Tyr Leu His Gly Ile Gly Ile Xaa 
        115                 120                 125         


<210> 6033
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<400> 6033
Met Ala Val Pro Phe Val Glu Asp Trp Asp Leu Val Gln Xaa Leu Gly 
1               5                   10                  15      


Glu Gly Ala Tyr Gly Glu Val Gln Leu Ala Val Asn Arg Val Xaa Glu 
            20                  25                  30          


Glu Ala Val Ala Val Lys Ile Val Asp Met Lys Arg Ala Val Asp Cys 
        35                  40                  45              


Pro Glu Asn Ile Lys Lys Glu Ile Cys Ile Asn Lys Met Leu Asn His 
    50                  55                  60                  


Glu Asn Val Val Lys Phe Tyr Gly His Arg Arg Glu Gly Asn Ile Gln 
65                  70                  75                  80  


Tyr Leu Phe Leu Glu Tyr Cys Ser Gly Gly Glu Leu Phe Asp Arg Ile 
                85                  90                  95      


Glu Pro Asp Ile Gly Met Pro Glu Pro Asp Ala Gln Arg Phe Phe His 
            100                 105                 110         


Gln Leu Met Ala Gly Val Val Tyr Leu His Gly Ile Gly Ile Xaa His 
        115                 120                 125             


Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Asp Glu Arg Asp Asn Leu 
    130                 135                 140                 


Lys Ile Ser Asp Phe Gly Leu Ala Xaa Val Phe Arg Tyr Asn Asn Arg 
145                 150                 155                 160 


Glu Arg Leu Leu Asn Lys Met Cys Gly Xaa 
                165                 170 


<210> 6034
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<400> 6034
Met Ala Val Pro Phe Val Glu Asp Trp Asp Leu Val Gln Xaa Leu Gly 
1               5                   10                  15      


Glu Gly Ala Tyr Gly Glu Val Gln Leu Ala Val Asn Arg Val Xaa Glu 
            20                  25                  30          


Glu Ala Val Ala Val Lys Ile Val Asp Met Lys Arg Ala Val Asp Cys 
        35                  40                  45              


Pro Glu Asn Ile Lys Lys Glu Ile Cys Ile Asn Lys Met Leu Asn His 
    50                  55                  60                  


Glu Asn Val Val Lys Phe Tyr Gly His Arg Arg Glu Gly Asn Ile Gln 
65                  70                  75                  80  


Tyr Leu Phe Leu Glu Tyr Cys Ser Gly Gly Glu Leu Phe Asp Arg Ile 
                85                  90                  95      


Glu Pro Asp Ile Gly Met Pro Glu Pro Asp Ala Gln Arg Phe Phe His 
            100                 105                 110         


Gln Leu Met Ala Gly Val Val Tyr Leu His Gly Ile Gly Ile Xaa His 
        115                 120                 125             


Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Asp Glu Arg Asp Asn Leu 
    130                 135                 140                 


Lys Ile Ser Asp Phe Gly Leu Ala Xaa Val Phe Arg Tyr Asn Asn Arg 
145                 150                 155                 160 


Glu Arg Leu Leu Asn Lys Met Cys Gly Xaa Leu Pro Tyr Val Ala Pro 
                165                 170                 175     


Glu Leu Leu Lys Arg Arg Glu Phe His Ala Glu Pro Val Asp Val Trp 
            180                 185                 190         


Ser Cys Gly Ile Val Leu Xaa Ala Met Leu Ala Gly 
        195                 200                 


<210> 6035
<211> 432
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<400> 6035
Met Ala Val Pro Phe Val Glu Asp Trp Asp Leu Val Gln Xaa Leu Gly 
1               5                   10                  15      


Glu Gly Ala Tyr Gly Glu Val Gln Leu Ala Val Asn Arg Val Xaa Glu 
            20                  25                  30          


Glu Ala Val Ala Val Lys Ile Val Asp Met Lys Arg Ala Val Asp Cys 
        35                  40                  45              


Pro Glu Asn Ile Lys Lys Glu Ile Cys Ile Asn Lys Met Leu Asn His 
    50                  55                  60                  


Glu Asn Val Val Lys Phe Tyr Gly His Arg Arg Glu Gly Asn Ile Gln 
65                  70                  75                  80  


Tyr Leu Phe Leu Glu Tyr Cys Ser Gly Gly Glu Leu Phe Asp Arg Ile 
                85                  90                  95      


Glu Pro Asp Ile Gly Met Pro Glu Pro Asp Ala Gln Arg Phe Phe His 
            100                 105                 110         


Gln Leu Met Ala Gly Val Val Tyr Leu His Gly Ile Gly Ile Xaa His 
        115                 120                 125             


Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Asp Glu Arg Asp Asn Leu 
    130                 135                 140                 


Lys Ile Ser Asp Phe Gly Leu Ala Xaa Val Phe Arg Tyr Asn Asn Arg 
145                 150                 155                 160 


Glu Arg Leu Leu Asn Lys Met Cys Gly Xaa Leu Pro Tyr Val Ala Pro 
                165                 170                 175     


Glu Leu Leu Lys Arg Arg Glu Phe His Ala Glu Pro Val Asp Val Trp 
            180                 185                 190         


Ser Cys Gly Ile Val Leu Xaa Ala Met Leu Ala Gly Glu Leu Pro Trp 
        195                 200                 205             


Asp Gln Pro Ser Asp Ser Cys Gln Glu Tyr Ser Asp Trp Lys Glu Lys 
    210                 215                 220                 


Lys Xaa Tyr Leu Asn Pro Trp Lys Lys Ile Asp Ser Ala Pro Leu Ala 
225                 230                 235                 240 


Leu Leu His Lys Ile Leu Val Glu Asn Pro Ser Ala Arg Ile Xaa Ile 
                245                 250                 255     


Pro Asp Ile Lys Lys Asp Arg Trp Tyr Asn Lys Pro Leu Lys Lys Gly 
            260                 265                 270         


Ala Lys Arg Pro Arg Val Xaa Ser Gly Gly Val Ser Glu Ser Pro Ser 
        275                 280                 285             


Gly Phe Ser Lys His Ile Gln Ser Asn Leu Asp Phe Ser Pro Val Asn 
    290                 295                 300                 


Ser Ala Ser Ser Glu Glu Asn Val Lys Tyr Ser Ser Ser Gln Pro Glu 
305                 310                 315                 320 


Pro Arg Xaa Gly Leu Ser Leu Trp Asp Xaa Ser Pro Ser Tyr Ile Asp 
                325                 330                 335     


Lys Leu Val Gln Gly Ile Ser Phe Ser Gln Pro Xaa Cys Pro Asp His 
            340                 345                 350         


Met Leu Leu Asn Ser Gln Leu Leu Gly Xaa Pro Gly Ser Ser Gln Val 
        355                 360                 365             


Xaa Ile Ser Xaa Xaa Asp Arg Arg Asn Asn Lys Leu Ile Phe Lys Val 
    370                 375                 380                 


Asn Leu Leu Glu Met Asp Asp Lys Ile Leu Val Asp Phe Arg Leu Ser 
385                 390                 395                 400 


Lys Gly Asp Gly Leu Glu Phe Lys Arg His Phe Leu Lys Ile Lys Gly 
                405                 410                 415     


Lys Leu Ile Asp Ile Val Ser Ser Gln Lys Ile Trp Leu Pro Ala Xaa 
            420                 425                 430         


<210> 6036
<211> 442
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<400> 6036
Met Ala Val Pro Phe Val Glu Asp Trp Asp Leu Val Gln Xaa Leu Gly 
1               5                   10                  15      


Glu Gly Ala Tyr Gly Glu Val Gln Leu Ala Val Asn Arg Val Xaa Glu 
            20                  25                  30          


Glu Ala Val Ala Val Lys Ile Val Asp Met Lys Arg Ala Val Asp Cys 
        35                  40                  45              


Pro Glu Asn Ile Lys Lys Glu Ile Cys Ile Asn Lys Met Leu Asn His 
    50                  55                  60                  


Glu Asn Val Val Lys Phe Tyr Gly His Arg Arg Glu Gly Asn Ile Gln 
65                  70                  75                  80  


Tyr Leu Phe Leu Glu Tyr Cys Ser Gly Gly Glu Leu Phe Asp Arg Ile 
                85                  90                  95      


Glu Pro Asp Ile Gly Met Pro Glu Pro Asp Ala Gln Arg Phe Phe His 
            100                 105                 110         


Gln Leu Met Ala Gly Val Val Tyr Leu His Gly Ile Gly Ile Xaa His 
        115                 120                 125             


Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Asp Glu Arg Asp Asn Leu 
    130                 135                 140                 


Lys Ile Ser Asp Phe Gly Leu Ala Xaa Val Phe Arg Tyr Asn Asn Arg 
145                 150                 155                 160 


Glu Arg Leu Leu Asn Lys Met Cys Gly Xaa Leu Pro Tyr Val Ala Pro 
                165                 170                 175     


Glu Leu Leu Lys Arg Arg Glu Phe His Ala Glu Pro Val Asp Val Trp 
            180                 185                 190         


Ser Cys Gly Ile Val Leu Xaa Ala Met Leu Ala Gly Glu Leu Pro Trp 
        195                 200                 205             


Asp Gln Pro Ser Asp Ser Cys Gln Glu Tyr Ser Asp Trp Lys Glu Lys 
    210                 215                 220                 


Lys Xaa Tyr Leu Asn Pro Trp Lys Lys Ile Asp Ser Ala Pro Leu Ala 
225                 230                 235                 240 


Leu Leu His Lys Ile Leu Val Glu Asn Pro Ser Ala Arg Ile Xaa Ile 
                245                 250                 255     


Pro Asp Ile Lys Lys Asp Arg Trp Tyr Asn Lys Pro Leu Lys Lys Gly 
            260                 265                 270         


Ala Lys Arg Pro Arg Val Xaa Ser Gly Gly Val Ser Glu Ser Pro Ser 
        275                 280                 285             


Gly Phe Ser Lys His Ile Gln Ser Asn Leu Asp Phe Ser Pro Val Asn 
    290                 295                 300                 


Ser Ala Ser Ser Glu Glu Asn Val Lys Tyr Ser Ser Ser Gln Pro Glu 
305                 310                 315                 320 


Pro Arg Xaa Gly Leu Ser Leu Trp Asp Xaa Ser Pro Ser Tyr Ile Asp 
                325                 330                 335     


Lys Leu Val Gln Gly Ile Ser Phe Ser Gln Pro Xaa Cys Pro Asp His 
            340                 345                 350         


Met Leu Leu Asn Ser Gln Leu Leu Gly Xaa Pro Gly Ser Ser Gln Asn 
        355                 360                 365             


Pro Trp Gln Arg Leu Val Lys Arg Met Xaa Arg Phe Phe Xaa Lys Leu 
    370                 375                 380                 


Asp Ala Asp Lys Ser Tyr Gln Cys Leu Lys Glu Xaa Cys Glu Lys Leu 
385                 390                 395                 400 


Gly Tyr Gln Trp Lys Lys Ser Cys Met Asn Gln Gly Asp Gly Leu Glu 
                405                 410                 415     


Phe Lys Arg His Phe Leu Lys Ile Lys Gly Lys Leu Ile Asp Ile Val 
            420                 425                 430         


Ser Ser Gln Lys Ile Trp Leu Pro Ala Xaa 
        435                 440         


<210> 6037
<211> 476
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<400> 6037
Met Ala Val Pro Phe Val Glu Asp Trp Asp Leu Val Gln Xaa Leu Gly 
1               5                   10                  15      


Glu Gly Ala Tyr Gly Glu Val Gln Leu Ala Val Asn Arg Val Xaa Glu 
            20                  25                  30          


Glu Ala Val Ala Val Lys Ile Val Asp Met Lys Arg Ala Val Asp Cys 
        35                  40                  45              


Pro Glu Asn Ile Lys Lys Glu Ile Cys Ile Asn Lys Met Leu Asn His 
    50                  55                  60                  


Glu Asn Val Val Lys Phe Tyr Gly His Arg Arg Glu Gly Asn Ile Gln 
65                  70                  75                  80  


Tyr Leu Phe Leu Glu Tyr Cys Ser Gly Gly Glu Leu Phe Asp Arg Ile 
                85                  90                  95      


Glu Pro Asp Ile Gly Met Pro Glu Pro Asp Ala Gln Arg Phe Phe His 
            100                 105                 110         


Gln Leu Met Ala Gly Val Val Tyr Leu His Gly Ile Gly Ile Xaa His 
        115                 120                 125             


Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Asp Glu Arg Asp Asn Leu 
    130                 135                 140                 


Lys Ile Ser Asp Phe Gly Leu Ala Xaa Val Phe Arg Tyr Asn Asn Arg 
145                 150                 155                 160 


Glu Arg Leu Leu Asn Lys Met Cys Gly Xaa Leu Pro Tyr Val Ala Pro 
                165                 170                 175     


Glu Leu Leu Lys Arg Arg Glu Phe His Ala Glu Pro Val Asp Val Trp 
            180                 185                 190         


Ser Cys Gly Ile Val Leu Xaa Ala Met Leu Ala Gly Glu Leu Pro Trp 
        195                 200                 205             


Asp Gln Pro Ser Asp Ser Cys Gln Glu Tyr Ser Asp Trp Lys Glu Lys 
    210                 215                 220                 


Lys Xaa Tyr Leu Asn Pro Trp Lys Lys Ile Asp Ser Ala Pro Leu Ala 
225                 230                 235                 240 


Leu Leu His Lys Ile Leu Val Glu Asn Pro Ser Ala Arg Ile Xaa Ile 
                245                 250                 255     


Pro Asp Ile Lys Lys Asp Arg Trp Tyr Asn Lys Pro Leu Lys Lys Gly 
            260                 265                 270         


Ala Lys Arg Pro Arg Val Xaa Ser Gly Gly Val Ser Glu Ser Pro Ser 
        275                 280                 285             


Gly Phe Ser Lys His Ile Gln Ser Asn Leu Asp Phe Ser Pro Val Asn 
    290                 295                 300                 


Ser Ala Ser Ser Glu Glu Asn Val Lys Tyr Ser Ser Ser Gln Pro Glu 
305                 310                 315                 320 


Pro Arg Xaa Gly Leu Ser Leu Trp Asp Xaa Ser Pro Ser Tyr Ile Asp 
                325                 330                 335     


Lys Leu Val Gln Gly Ile Ser Phe Ser Gln Pro Xaa Cys Pro Asp His 
            340                 345                 350         


Met Leu Leu Asn Ser Gln Leu Leu Gly Xaa Pro Gly Ser Ser Gln Asn 
        355                 360                 365             


Pro Trp Gln Arg Leu Val Lys Arg Met Xaa Arg Phe Phe Xaa Lys Leu 
    370                 375                 380                 


Asp Ala Asp Lys Ser Tyr Gln Cys Leu Lys Glu Xaa Cys Glu Lys Leu 
385                 390                 395                 400 


Gly Tyr Gln Trp Lys Lys Ser Cys Met Asn Gln Val Xaa Ile Ser Xaa 
                405                 410                 415     


Xaa Asp Arg Arg Asn Asn Lys Leu Ile Phe Lys Val Asn Leu Leu Glu 
            420                 425                 430         


Met Asp Asp Lys Ile Leu Val Asp Phe Arg Leu Ser Lys Gly Asp Gly 
        435                 440                 445             


Leu Glu Phe Lys Arg His Phe Leu Lys Ile Lys Gly Lys Leu Ile Asp 
    450                 455                 460                 


Ile Val Ser Ser Gln Lys Ile Trp Leu Pro Ala Xaa 
465                 470                 475     


<210> 6038
<211> 382
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<400> 6038
Met Glu Lys Pro Asp Ile Gly Met Pro Glu Pro Asp Ala Gln Arg Phe 
1               5                   10                  15      


Phe His Gln Leu Met Ala Gly Val Val Tyr Leu His Gly Ile Gly Ile 
            20                  25                  30          


Xaa His Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Asp Glu Arg Asp 
        35                  40                  45              


Asn Leu Lys Ile Ser Asp Phe Gly Leu Ala Xaa Val Phe Arg Tyr Asn 
    50                  55                  60                  


Asn Arg Glu Arg Leu Leu Asn Lys Met Cys Gly Xaa Leu Pro Tyr Val 
65                  70                  75                  80  


Ala Pro Glu Leu Leu Lys Arg Arg Glu Phe His Ala Glu Pro Val Asp 
                85                  90                  95      


Val Trp Ser Cys Gly Ile Val Leu Xaa Ala Met Leu Ala Gly Glu Leu 
            100                 105                 110         


Pro Trp Asp Gln Pro Ser Asp Ser Cys Gln Glu Tyr Ser Asp Trp Lys 
        115                 120                 125             


Glu Lys Lys Xaa Tyr Leu Asn Pro Trp Lys Lys Ile Asp Ser Ala Pro 
    130                 135                 140                 


Leu Ala Leu Leu His Lys Ile Leu Val Glu Asn Pro Ser Ala Arg Ile 
145                 150                 155                 160 


Xaa Ile Pro Asp Ile Lys Lys Asp Arg Trp Tyr Asn Lys Pro Leu Lys 
                165                 170                 175     


Lys Gly Ala Lys Arg Pro Arg Val Xaa Ser Gly Gly Val Ser Glu Ser 
            180                 185                 190         


Pro Ser Gly Phe Ser Lys His Ile Gln Ser Asn Leu Asp Phe Ser Pro 
        195                 200                 205             


Val Asn Ser Ala Ser Ser Glu Glu Asn Val Lys Tyr Ser Ser Ser Gln 
    210                 215                 220                 


Pro Glu Pro Arg Xaa Gly Leu Ser Leu Trp Asp Xaa Ser Pro Ser Tyr 
225                 230                 235                 240 


Ile Asp Lys Leu Val Gln Gly Ile Ser Phe Ser Gln Pro Xaa Cys Pro 
                245                 250                 255     


Asp His Met Leu Leu Asn Ser Gln Leu Leu Gly Xaa Pro Gly Ser Ser 
            260                 265                 270         


Gln Asn Pro Trp Gln Arg Leu Val Lys Arg Met Xaa Arg Phe Phe Xaa 
        275                 280                 285             


Lys Leu Asp Ala Asp Lys Ser Tyr Gln Cys Leu Lys Glu Xaa Cys Glu 
    290                 295                 300                 


Lys Leu Gly Tyr Gln Trp Lys Lys Ser Cys Met Asn Gln Val Xaa Ile 
305                 310                 315                 320 


Ser Xaa Xaa Asp Arg Arg Asn Asn Lys Leu Ile Phe Lys Val Asn Leu 
                325                 330                 335     


Leu Glu Met Asp Asp Lys Ile Leu Val Asp Phe Arg Leu Ser Lys Gly 
            340                 345                 350         


Asp Gly Leu Glu Phe Lys Arg His Phe Leu Lys Ile Lys Gly Lys Leu 
        355                 360                 365             


Ile Asp Ile Val Ser Ser Gln Lys Ile Trp Leu Pro Ala Xaa 
    370                 375                 380         


<210> 6039
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 6039
Met Lys Arg Ala Val Asp Cys Pro Glu Asn Ile Lys Lys Glu Ile Cys 
1               5                   10                  15      


Ile Asn Lys Met Leu Asn His Glu Asn Val Val Lys Phe Tyr Gly His 
            20                  25                  30          


Arg Arg Glu Gly Asn Ile Gln Tyr Leu Phe Leu Glu Tyr Cys Ser Gly 
        35                  40                  45              


Gly Glu Leu Phe Asp Arg Ile Glu Pro Asp Ile Gly Met Pro Glu Pro 
    50                  55                  60                  


Asp Ala Gln Arg Phe Phe His Gln Leu Met Ala Gly Val Val Tyr Leu 
65                  70                  75                  80  


His Gly Ile Gly Ile Xaa His Arg Asp Ile Lys Pro Glu Asn Leu Leu 
                85                  90                  95      


Leu Asp Glu Arg Asp Asn Leu Lys Ile Ser Asp Phe Gly Leu Ala 
            100                 105                 110     


<210> 6040
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<400> 6040
Met Arg Ser Ala Val Leu Lys Ser Leu Gln Pro Gly Ser Leu Pro Asp 
1               5                   10                  15      


Cys Lys Ala Ala Leu Gly Gly Ser Gly Asn Ile Ser Xaa Ser Pro Phe 
            20                  25                  30          


Trp Ser Arg Arg His Ser Glu Gly Gln Asp Xaa Gly Xaa Arg Ala Val 
        35                  40                  45              


Leu Leu Tyr Gly Ala Gly Ala Arg Val Cys Gly Ser Val Xaa Pro Ser 
    50                  55                  60                  


Ser Phe Gly Gly Lys Ser Ala Ala Phe Gly Phe Leu Gln Trp Trp Ala 
65                  70                  75                  80  


Lys Asp Ser Pro Pro Arg Cys Ser Val Glu Ser Trp Gln Cys Pro Leu 
                85                  90                  95      


Trp Lys Xaa Gly Xaa Trp Cys Lys Pro Trp Glu Lys Val Pro Met Glu 
            100                 105                 110         


Lys Phe Asn Leu Leu 
        115         


<210> 6041
<211> 492
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<400> 6041
Met Arg Ser Ala Val Leu Lys Ser Leu Gln Pro Gly Ser Leu Pro Asp 
1               5                   10                  15      


Cys Lys Ala Ala Leu Gly Gly Ser Gly Asn Ile Ser Xaa Ser Pro Phe 
            20                  25                  30          


Trp Ser Arg Arg His Ser Glu Gly Gln Asp Xaa Gly Xaa Arg Ala Val 
        35                  40                  45              


Leu Leu Tyr Gly Ala Gly Ala Arg Val Cys Gly Ser Val Xaa Pro Ser 
    50                  55                  60                  


Ser Phe Gly Gly Lys Ser Ala Ala Phe Gly Phe Leu Gln Trp Trp Ala 
65                  70                  75                  80  


Lys Asp Ser Pro Pro Arg Cys Ser Val Glu Ser Trp Gln Cys Pro Leu 
                85                  90                  95      


Trp Lys Xaa Gly Xaa Trp Cys Lys Pro Trp Glu Lys Val Pro Met Glu 
            100                 105                 110         


Lys Pro Asp Ile Gly Met Pro Glu Pro Asp Ala Gln Arg Phe Phe His 
        115                 120                 125             


Gln Leu Met Ala Gly Val Val Tyr Leu His Gly Ile Gly Ile Xaa His 
    130                 135                 140                 


Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Asp Glu Arg Asp Asn Leu 
145                 150                 155                 160 


Lys Ile Ser Asp Phe Gly Leu Ala Xaa Val Phe Arg Tyr Asn Asn Arg 
                165                 170                 175     


Glu Arg Leu Leu Asn Lys Met Cys Gly Xaa Leu Pro Tyr Val Ala Pro 
            180                 185                 190         


Glu Leu Leu Lys Arg Arg Glu Phe His Ala Glu Pro Val Asp Val Trp 
        195                 200                 205             


Ser Cys Gly Ile Val Leu Xaa Ala Met Leu Ala Gly Glu Leu Pro Trp 
    210                 215                 220                 


Asp Gln Pro Ser Asp Ser Cys Gln Glu Tyr Ser Asp Trp Lys Glu Lys 
225                 230                 235                 240 


Lys Xaa Tyr Leu Asn Pro Trp Lys Lys Ile Asp Ser Ala Pro Leu Ala 
                245                 250                 255     


Leu Leu His Lys Ile Leu Val Glu Asn Pro Ser Ala Arg Ile Xaa Ile 
            260                 265                 270         


Pro Asp Ile Lys Lys Asp Arg Trp Tyr Asn Lys Pro Leu Lys Lys Gly 
        275                 280                 285             


Ala Lys Arg Pro Arg Val Xaa Ser Gly Gly Val Ser Glu Ser Pro Ser 
    290                 295                 300                 


Gly Phe Ser Lys His Ile Gln Ser Asn Leu Asp Phe Ser Pro Val Asn 
305                 310                 315                 320 


Ser Ala Ser Ser Glu Glu Asn Val Lys Tyr Ser Ser Ser Gln Pro Glu 
                325                 330                 335     


Pro Arg Xaa Gly Leu Ser Leu Trp Asp Xaa Ser Pro Ser Tyr Ile Asp 
            340                 345                 350         


Lys Leu Val Gln Gly Ile Ser Phe Ser Gln Pro Xaa Cys Pro Asp His 
        355                 360                 365             


Met Leu Leu Asn Ser Gln Leu Leu Gly Xaa Pro Gly Ser Ser Gln Asn 
    370                 375                 380                 


Pro Trp Gln Arg Leu Val Lys Arg Met Xaa Arg Phe Phe Xaa Lys Leu 
385                 390                 395                 400 


Asp Ala Asp Lys Ser Tyr Gln Cys Leu Lys Glu Xaa Cys Glu Lys Leu 
                405                 410                 415     


Gly Tyr Gln Trp Lys Lys Ser Cys Met Asn Gln Val Xaa Ile Ser Xaa 
            420                 425                 430         


Xaa Asp Arg Arg Asn Asn Lys Leu Ile Phe Lys Val Asn Leu Leu Glu 
        435                 440                 445             


Met Asp Asp Lys Ile Leu Val Asp Phe Arg Leu Ser Lys Gly Asp Gly 
    450                 455                 460                 


Leu Glu Phe Lys Arg His Phe Leu Lys Ile Lys Gly Lys Leu Ile Asp 
465                 470                 475                 480 


Ile Val Ser Ser Gln Lys Ile Trp Leu Pro Ala Xaa 
                485                 490         


<210> 6042
<211> 57
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<400> 6042
Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile Glu Asp 
1               5                   10                  15      


His Ser Gly Asn Gly Xaa Phe Val Asn Xaa Glu Leu Val Gly Lys Gly 
            20                  25                  30          


Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser Leu Ser 
        35                  40                  45              


Arg Asn Lys Val Val Pro Val Glu Arg 
    50                  55          


<210> 6043
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 6043
Met Glu Arg Leu Leu Tyr Gly Ile Gly Ala Cys Gly Glu Val Lys Leu 
1               5                   10                  15      


Ala Phe Glu Arg Lys Xaa Cys Lys Lys Val Ala Ile Lys Ile Ile Ser 
            20                  25                  30          


Lys Arg Lys Phe Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu 
        35                  40                  45              


Asn Val Glu Xaa Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys 
    50                  55                  60                  


Ile Ile Lys Ile Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val 
65                  70                  75                  80  


Leu Glu Leu Met Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn 
                85                  90                  95      


Lys Arg Leu Lys Glu Ala Xaa Cys Lys Leu Tyr Phe Tyr Gln Met Leu 
            100                 105                 110         


Leu Ala Val Gln Tyr Leu His Glu Asn Gly Ile Ile His Arg Asp Leu 
        115                 120                 125             


Lys Pro Glu Asn Val Leu Leu Ser Ser 
    130                 135         


<210> 6044
<211> 172
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 6044
Met Leu Arg Leu Leu Xaa Ser Met Val Val Met Ser Arg Glu Ser Asp 
1               5                   10                  15      


Val Glu Ala Gln Gln Ser His Gly Ser Ser Ala Cys Ser Gln Pro His 
            20                  25                  30          


Gly Ser Val Xaa Gln Ser Gln Gly Ser Ser Ser Gln Ser Gln Gly Ile 
        35                  40                  45              


Ser Ser Ser Ser Xaa Ser Xaa Met Pro Asn Ser Ser Gln Ser Ser His 
    50                  55                  60                  


Ser Ser Ser Gly Xaa Leu Ser Ser Leu Glu Xaa Val Ser Xaa Gln Glu 
65                  70                  75                  80  


Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro Glu Asp Gln Glu Pro Glu 
                85                  90                  95      


Glu Pro Xaa Pro Ala Pro Trp Ala Arg Leu Trp Ala Leu Gln Asp Gly 
            100                 105                 110         


Phe Ala Asn Leu Glu Cys Val Asn Asp Asn Tyr Trp Phe Gly Arg Asp 
        115                 120                 125             


Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro Leu Leu Lys Arg Xaa Asp 
    130                 135                 140                 


Lys Tyr Arg Xaa Tyr Ser Lys Lys His Phe Arg Ile Phe Arg Glu Val 
145                 150                 155                 160 


Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile Glu Asp 
                165                 170         


<210> 6045
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<400> 6045
Met Ser Lys Xaa Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala 
1               5                   10                  15      


Phe Glu Arg Lys Xaa Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys 
            20                  25                  30          


Arg Lys Phe Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn 
        35                  40                  45              


Val Glu Xaa Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys Ile 
    50                  55                  60                  


Ile Lys Ile Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu 
65                  70                  75                  80  


Glu Leu Met Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn Lys 
                85                  90                  95      


Arg Leu Lys Glu Ala Xaa Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu 
            100                 105                 110         


Ala Val Gln Tyr Leu His Glu Asn Gly 
        115                 120     


<210> 6046
<211> 161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<400> 6046
Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Xaa Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Xaa Ser Xaa Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Xaa Leu Ser Ser Leu Glu 
    50                  55                  60                  


Xaa Val Ser Xaa Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Xaa Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Xaa Asp Lys Tyr Arg Xaa Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Glu Asn Leu Ser Cys Pro Tyr Arg Ile Trp Phe 
145                 150                 155                 160 


Lys 
    


<210> 6047
<211> 165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<400> 6047
Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Xaa Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Xaa Ser Xaa Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Xaa Leu Ser Ser Leu Glu 
    50                  55                  60                  


Xaa Val Ser Xaa Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Xaa Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Xaa Asp Lys Tyr Arg Xaa Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Glu Asn Leu Ser Cys Pro Tyr Arg Ile Trp Phe 
145                 150                 155                 160 


Asn Phe Cys Leu Phe 
                165 


<210> 6048
<211> 298
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<400> 6048
Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Xaa Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Xaa Ser Xaa Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Xaa Leu Ser Ser Leu Glu 
    50                  55                  60                  


Xaa Val Ser Xaa Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Xaa Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Xaa Asp Lys Tyr Arg Xaa Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Glu Asn Leu Ser Cys Pro Tyr Arg Ile Trp Phe 
145                 150                 155                 160 


Asn Gly Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg Lys Xaa Cys 
                165                 170                 175     


Lys Lys Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe Ala Ile Gly 
            180                 185                 190         


Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Xaa Glu Ile Glu 
        195                 200                 205             


Ile Leu Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile Lys Asn Phe 
    210                 215                 220                 


Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met Glu Gly Gly 
225                 230                 235                 240 


Glu Leu Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys Glu Ala Xaa 
                245                 250                 255     


Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln Tyr Leu His 
            260                 265                 270         


Glu Asn Gly Ile Ile His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu 
        275                 280                 285             


Ser Ser Gln Glu Glu Asp Cys Leu Ile Lys 
    290                 295             


<210> 6049
<211> 207
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<400> 6049
Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Xaa Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Xaa Ser Xaa Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Xaa Leu Ser Ser Leu Glu 
    50                  55                  60                  


Xaa Val Ser Xaa Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Xaa Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Xaa Asp Lys Tyr Arg Xaa Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Xaa Phe Val Asn Xaa Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Glu Lys Ile Leu Lys Ile Tyr Ser Leu Ser 
        195                 200                 205         


<210> 6050
<211> 289
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<400> 6050
Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Xaa Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Xaa Ser Xaa Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Xaa Leu Ser Ser Leu Glu 
    50                  55                  60                  


Xaa Val Ser Xaa Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Xaa Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Xaa Asp Lys Tyr Arg Xaa Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Xaa Phe Val Asn Xaa Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Val Phe Val Phe Phe Asp Leu Xaa Val Asp Asp 
        195                 200                 205             


Gln Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys 
    210                 215                 220                 


Xaa Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg 
225                 230                 235                 240 


Lys Xaa Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe 
                245                 250                 255     


Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Xaa 
            260                 265                 270         


Glu Ile Glu Ile Leu Lys Lys Leu Asn His Asp Gly Arg Gly Arg Ala 
        275                 280                 285             


Val 
    


<210> 6051
<211> 514
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(504)
<223> Selenocysteine

<400> 6051
Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Xaa Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Xaa Ser Xaa Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Xaa Leu Ser Ser Leu Glu 
    50                  55                  60                  


Xaa Val Ser Xaa Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Xaa Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Xaa Asp Lys Tyr Arg Xaa Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Xaa Phe Val Asn Xaa Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Val Phe Val Phe Phe Asp Leu Xaa Val Asp Asp 
        195                 200                 205             


Gln Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys 
    210                 215                 220                 


Xaa Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg 
225                 230                 235                 240 


Lys Xaa Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe 
                245                 250                 255     


Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Xaa 
            260                 265                 270         


Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile 
        275                 280                 285             


Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met 
    290                 295                 300                 


Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys 
305                 310                 315                 320 


Glu Ala Xaa Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln 
                325                 330                 335     


Ile Xaa Asp Phe Gly His Ser Lys Ile Leu Gly Glu Xaa Ser Leu Met 
            340                 345                 350         


Arg Xaa Leu Cys Gly Xaa Pro Xaa Tyr Leu Ala Pro Glu Val Leu Val 
        355                 360                 365             


Ser Val Gly Xaa Ala Gly Tyr Asn Arg Ala Val Asp Cys Trp Ser Leu 
    370                 375                 380                 


Gly Val Ile Leu Phe Ile Cys Leu Ser Gly Tyr Pro Pro Phe Ser Glu 
385                 390                 395                 400 


His Arg Xaa Gln Val Ser Leu Lys Asp Gln Ile Xaa Ser Gly Lys Tyr 
                405                 410                 415     


Asn Phe Ile Pro Glu Val Trp Ala Glu Val Ser Glu Lys Ala Leu Asp 
            420                 425                 430         


Leu Val Lys Lys Leu Leu Val Val Asp Pro Lys Ala Arg Phe Xaa Xaa 
        435                 440                 445             


Glu Glu Ala Leu Arg His Pro Trp Leu Gln Asp Glu Asp Met Lys Arg 
    450                 455                 460                 


Lys Phe Gln Asp Leu Leu Ser Glu Glu Asn Glu Ser Xaa Ala Leu Pro 
465                 470                 475                 480 


Gln Val Leu Ala Gln Pro Ser Xaa Ser Arg Lys Arg Pro Arg Glu Gly 
                485                 490                 495     


Glu Ala Glu Gly Ala Glu Xaa Xaa Lys Arg Pro Ala Val Cys Ala Ala 
            500                 505                 510         


Val Leu 
        


<210> 6052
<211> 543
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(533)
<223> Selenocysteine

<400> 6052
Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Xaa Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Xaa Ser Xaa Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Xaa Leu Ser Ser Leu Glu 
    50                  55                  60                  


Xaa Val Ser Xaa Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Xaa Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Xaa Asp Lys Tyr Arg Xaa Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Xaa Phe Val Asn Xaa Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Val Phe Val Phe Phe Asp Leu Xaa Val Asp Asp 
        195                 200                 205             


Gln Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys 
    210                 215                 220                 


Xaa Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg 
225                 230                 235                 240 


Lys Xaa Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe 
                245                 250                 255     


Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Xaa 
            260                 265                 270         


Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile 
        275                 280                 285             


Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met 
    290                 295                 300                 


Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys 
305                 310                 315                 320 


Glu Ala Xaa Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln 
                325                 330                 335     


Tyr Leu His Glu Asn Gly Ile Ile His Arg Asp Leu Lys Pro Glu Asn 
            340                 345                 350         


Val Leu Leu Ser Ser Gln Glu Glu Asp Cys Leu Ile Lys Ile Xaa Asp 
        355                 360                 365             


Phe Gly His Ser Lys Ile Leu Gly Glu Xaa Ser Leu Met Arg Xaa Leu 
    370                 375                 380                 


Cys Gly Xaa Pro Xaa Tyr Leu Ala Pro Glu Val Leu Val Ser Val Gly 
385                 390                 395                 400 


Xaa Ala Gly Tyr Asn Arg Ala Val Asp Cys Trp Ser Leu Gly Val Ile 
                405                 410                 415     


Leu Phe Ile Cys Leu Ser Gly Tyr Pro Pro Phe Ser Glu His Arg Xaa 
            420                 425                 430         


Gln Val Ser Leu Lys Asp Gln Ile Xaa Ser Gly Lys Tyr Asn Phe Ile 
        435                 440                 445             


Pro Glu Val Trp Ala Glu Val Ser Glu Lys Ala Leu Asp Leu Val Lys 
    450                 455                 460                 


Lys Leu Leu Val Val Asp Pro Lys Ala Arg Phe Xaa Xaa Glu Glu Ala 
465                 470                 475                 480 


Leu Arg His Pro Trp Leu Gln Asp Glu Asp Met Lys Arg Lys Phe Gln 
                485                 490                 495     


Asp Leu Leu Ser Glu Glu Asn Glu Ser Xaa Ala Leu Pro Gln Val Leu 
            500                 505                 510         


Ala Gln Pro Ser Xaa Ser Arg Lys Arg Pro Arg Glu Gly Glu Ala Glu 
        515                 520                 525             


Gly Ala Glu Xaa Xaa Lys Arg Pro Ala Val Cys Ala Ala Val Leu 
    530                 535                 540             


<210> 6053
<211> 203
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<400> 6053
Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Xaa Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Xaa Ser Xaa Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Xaa Leu Ser Ser Leu Glu 
    50                  55                  60                  


Xaa Val Ser Xaa Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Xaa Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Xaa Asp Lys Tyr Arg Xaa Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Xaa Phe Val Asn Xaa Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Val Val Pro Val Glu Arg 
        195                 200             


<210> 6054
<211> 295
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<400> 6054
Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Xaa Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Xaa Ser Xaa Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Xaa Leu Ser Ser Leu Glu 
    50                  55                  60                  


Xaa Val Ser Xaa Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Xaa Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Xaa Glu Ser Gly His 
            100                 105                 110         


Val Xaa Gln Ser Asp Leu Glu Leu Leu Leu Ser Ser Asp Pro Pro Ala 
        115                 120                 125             


Ser Ala Ser Gln Ser Ala Gly Ile Arg Glu Cys Val Asn Asp Asn Tyr 
    130                 135                 140                 


Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro Leu 
145                 150                 155                 160 


Leu Lys Arg Xaa Asp Lys Tyr Arg Xaa Tyr Ser Lys Lys His Phe Arg 
                165                 170                 175     


Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile Glu 
            180                 185                 190         


Asp His Ser Gly Asn Gly Xaa Phe Val Asn Xaa Glu Leu Val Gly Lys 
        195                 200                 205             


Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser Leu 
    210                 215                 220                 


Ser Arg Asn Lys Val Phe Val Phe Phe Asp Leu Xaa Val Asp Asp Gln 
225                 230                 235                 240 


Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys Xaa 
                245                 250                 255     


Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg Lys 
            260                 265                 270         


Xaa Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe Ala 
        275                 280                 285             


Ile Gly Ser Ala Arg Glu Ala 
    290                 295 


<210> 6055
<211> 586
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(576)
<223> Selenocysteine

<400> 6055
Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Xaa Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Xaa Ser Xaa Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Xaa Leu Ser Ser Leu Glu 
    50                  55                  60                  


Xaa Val Ser Xaa Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Xaa Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Xaa Glu Ser Gly His 
            100                 105                 110         


Val Xaa Gln Ser Asp Leu Glu Leu Leu Leu Ser Ser Asp Pro Pro Ala 
        115                 120                 125             


Ser Ala Ser Gln Ser Ala Gly Ile Arg Gly Val Arg His His Pro Arg 
    130                 135                 140                 


Pro Val Cys Ser Leu Lys Cys Val Asn Asp Asn Tyr Trp Phe Gly Arg 
145                 150                 155                 160 


Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro Leu Leu Lys Arg Xaa 
                165                 170                 175     


Asp Lys Tyr Arg Xaa Tyr Ser Lys Lys His Phe Arg Ile Phe Arg Glu 
            180                 185                 190         


Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile Glu Asp His Ser Gly 
        195                 200                 205             


Asn Gly Xaa Phe Val Asn Xaa Glu Leu Val Gly Lys Gly Lys Arg Arg 
    210                 215                 220                 


Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser Leu Ser Arg Asn Lys 
225                 230                 235                 240 


Val Phe Val Phe Phe Asp Leu Xaa Val Asp Asp Gln Ser Val Tyr Pro 
                245                 250                 255     


Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys Xaa Leu Gly Ser Gly 
            260                 265                 270         


Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg Lys Xaa Cys Lys Lys 
        275                 280                 285             


Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe Ala Ile Gly Ser Ala 
    290                 295                 300                 


Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Xaa Glu Ile Glu Ile Leu 
305                 310                 315                 320 


Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile Lys Asn Phe Phe Asp 
                325                 330                 335     


Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met Glu Gly Gly Glu Leu 
            340                 345                 350         


Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys Glu Ala Xaa Cys Lys 
        355                 360                 365             


Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln Tyr Leu His Glu Asn 
    370                 375                 380                 


Gly Ile Ile His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Ser Ser 
385                 390                 395                 400 


Gln Glu Glu Asp Cys Leu Ile Lys Ile Xaa Asp Phe Gly His Ser Lys 
                405                 410                 415     


Ile Leu Gly Glu Xaa Ser Leu Met Arg Xaa Leu Cys Gly Xaa Pro Xaa 
            420                 425                 430         


Tyr Leu Ala Pro Glu Val Leu Val Ser Val Gly Xaa Ala Gly Tyr Asn 
        435                 440                 445             


Arg Ala Val Asp Cys Trp Ser Leu Gly Val Ile Leu Phe Ile Cys Leu 
    450                 455                 460                 


Ser Gly Tyr Pro Pro Phe Ser Glu His Arg Xaa Gln Val Ser Leu Lys 
465                 470                 475                 480 


Asp Gln Ile Xaa Ser Gly Lys Tyr Asn Phe Ile Pro Glu Val Trp Ala 
                485                 490                 495     


Glu Val Ser Glu Lys Ala Leu Asp Leu Val Lys Lys Leu Leu Val Val 
            500                 505                 510         


Asp Pro Lys Ala Arg Phe Xaa Xaa Glu Glu Ala Leu Arg His Pro Trp 
        515                 520                 525             


Leu Gln Asp Glu Asp Met Lys Arg Lys Phe Gln Asp Leu Leu Ser Glu 
    530                 535                 540                 


Glu Asn Glu Ser Xaa Ala Leu Pro Gln Val Leu Ala Gln Pro Ser Xaa 
545                 550                 555                 560 


Ser Arg Lys Arg Pro Arg Glu Gly Glu Ala Glu Gly Ala Glu Xaa Xaa 
                565                 570                 575     


Lys Arg Pro Ala Val Cys Ala Ala Val Leu 
            580                 585     


<210> 6056
<211> 452
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(442)
<223> Selenocysteine

<400> 6056
Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Xaa Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Xaa Ser Xaa Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Xaa Leu Ser Ser Leu Glu 
    50                  55                  60                  


Xaa Val Ser Xaa Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Xaa Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Val Phe Val Phe Phe Asp 
            100                 105                 110         


Leu Xaa Val Asp Asp Gln Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu 
        115                 120                 125             


Tyr Ile Met Ser Lys Xaa Leu Gly Ser Gly Ala Cys Gly Glu Val Lys 
    130                 135                 140                 


Leu Ala Phe Glu Arg Lys Xaa Cys Lys Lys Val Ala Ile Lys Ile Ile 
145                 150                 155                 160 


Ser Lys Arg Lys Phe Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala 
                165                 170                 175     


Leu Asn Val Glu Xaa Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro 
            180                 185                 190         


Cys Ile Ile Lys Ile Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile 
        195                 200                 205             


Val Leu Glu Leu Met Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly 
    210                 215                 220                 


Asn Lys Arg Leu Lys Glu Ala Xaa Cys Lys Leu Tyr Phe Tyr Gln Met 
225                 230                 235                 240 


Leu Leu Ala Val Gln Tyr Leu His Glu Asn Gly Ile Ile His Arg Asp 
                245                 250                 255     


Leu Lys Pro Glu Asn Val Leu Leu Ser Ser Gln Glu Glu Asp Cys Leu 
            260                 265                 270         


Ile Lys Ile Xaa Asp Phe Gly His Ser Lys Ile Leu Gly Glu Xaa Ser 
        275                 280                 285             


Leu Met Arg Xaa Leu Cys Gly Xaa Pro Xaa Tyr Leu Ala Pro Glu Val 
    290                 295                 300                 


Leu Val Ser Val Gly Xaa Ala Gly Tyr Asn Arg Ala Val Asp Cys Trp 
305                 310                 315                 320 


Ser Leu Gly Val Ile Leu Phe Ile Cys Leu Ser Gly Tyr Pro Pro Phe 
                325                 330                 335     


Ser Glu His Arg Xaa Gln Val Ser Leu Lys Asp Gln Ile Xaa Ser Gly 
            340                 345                 350         


Lys Tyr Asn Phe Ile Pro Glu Val Trp Ala Glu Val Ser Glu Lys Ala 
        355                 360                 365             


Leu Asp Leu Val Lys Lys Leu Leu Val Val Asp Pro Lys Ala Arg Phe 
    370                 375                 380                 


Xaa Xaa Glu Glu Ala Leu Arg His Pro Trp Leu Gln Asp Glu Asp Met 
385                 390                 395                 400 


Lys Arg Lys Phe Gln Asp Leu Leu Ser Glu Glu Asn Glu Ser Xaa Ala 
                405                 410                 415     


Leu Pro Gln Val Leu Ala Gln Pro Ser Xaa Ser Arg Lys Arg Pro Arg 
            420                 425                 430         


Glu Gly Glu Ala Glu Gly Ala Glu Xaa Xaa Lys Arg Pro Ala Val Cys 
        435                 440                 445             


Ala Ala Val Leu 
    450         


<210> 6057
<211> 45
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<400> 6057
Ser Ser Asp Pro Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Arg Gly 
1               5                   10                  15      


Val Arg His His Pro Arg Pro Val Cys Ser Leu Ile Glu Xaa Gly Phe 
            20                  25                  30          


His Arg Val Ser Gln Asp Gly Leu His Leu Leu Xaa Ser 
        35                  40                  45  


<210> 6058
<211> 276
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(266)
<223> Selenocysteine

<400> 6058
Xaa Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Xaa 
1               5                   10                  15      


Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile 
            20                  25                  30          


Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met 
        35                  40                  45              


Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys 
    50                  55                  60                  


Glu Ala Xaa Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln 
65                  70                  75                  80  


Tyr Leu His Glu Asn Gly Ile Ile His Arg Asp Leu Lys Pro Glu Asn 
                85                  90                  95      


Val Leu Leu Ser Ser Gln Glu Glu Asp Cys Leu Ile Lys Ile Xaa Asp 
            100                 105                 110         


Phe Gly His Ser Lys Ile Leu Gly Glu Xaa Ser Leu Met Arg Xaa Leu 
        115                 120                 125             


Cys Gly Xaa Pro Xaa Tyr Leu Ala Pro Glu Val Leu Val Ser Val Gly 
    130                 135                 140                 


Xaa Ala Gly Tyr Asn Arg Ala Val Asp Cys Trp Ser Leu Gly Val Ile 
145                 150                 155                 160 


Leu Phe Ile Trp Xaa Gln Val Ser Leu Lys Asp Gln Ile Xaa Ser Gly 
                165                 170                 175     


Lys Tyr Asn Phe Ile Pro Glu Val Trp Ala Glu Val Ser Glu Lys Ala 
            180                 185                 190         


Leu Asp Leu Val Lys Lys Leu Leu Val Val Asp Pro Lys Ala Arg Phe 
        195                 200                 205             


Xaa Xaa Glu Glu Ala Leu Arg His Pro Trp Leu Gln Asp Glu Asp Met 
    210                 215                 220                 


Lys Arg Lys Phe Gln Asp Leu Leu Ser Glu Glu Asn Glu Ser Xaa Ala 
225                 230                 235                 240 


Leu Pro Gln Val Leu Ala Gln Pro Ser Xaa Ser Arg Lys Arg Pro Arg 
                245                 250                 255     


Glu Gly Glu Ala Glu Gly Ala Glu Xaa Xaa Lys Arg Pro Ala Val Cys 
            260                 265                 270         


Ala Ala Val Leu 
        275     


<210> 6059
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(134)
<223> Selenocysteine

<400> 6059
Xaa Ile Ile Ser Lys Arg Lys Phe Ala Ile Gly Ser Ala Arg Glu Ala 
1               5                   10                  15      


Asp Pro Ala Leu Asn Val Glu Xaa Glu Ile Glu Ile Leu Lys Lys Leu 
            20                  25                  30          


Asn His Pro Cys Ile Ile Lys Ile Lys Asn Phe Phe Asp Ala Glu Asp 
        35                  40                  45              


Tyr Tyr Ile Val Leu Glu Leu Met Glu Gly Gly Glu Leu Phe Asp Lys 
    50                  55                  60                  


Val Val Gly Asn Lys Arg Leu Lys Glu Ala Xaa Cys Lys Leu Tyr Phe 
65                  70                  75                  80  


Tyr Gln Met Leu Leu Ala Val Gln Asp Glu Asp Met Lys Arg Lys Phe 
                85                  90                  95      


Gln Asp Leu Leu Ser Glu Glu Asn Glu Ser Xaa Ala Leu Pro Gln Val 
            100                 105                 110         


Leu Ala Gln Pro Ser Xaa Ser Arg Lys Arg Pro Arg Glu Gly Glu Ala 
        115                 120                 125             


Glu Gly Ala Glu Xaa Xaa Lys Arg Pro Ala Val Cys Ala Ala Val Leu 
    130                 135                 140                 


<210> 6060
<211> 38
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<400> 6060
Met Arg Ser Ala Ala Val Leu Ala Leu Leu Leu Cys Ala Gly Gln Val 
1               5                   10                  15      


Xaa Ala Leu Pro Val Asn Ser Pro Met Asn Lys Gly Asp Xaa Glu Met 
            20                  25                  30          


Asn Gly Ser Phe Pro Phe 
        35              


<210> 6061
<211> 457
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<400> 6061
Met Arg Ser Ala Ala Val Leu Ala Leu Leu Leu Cys Ala Gly Gln Val 
1               5                   10                  15      


Xaa Ala Leu Pro Val Asn Ser Pro Met Asn Lys Gly Asp Xaa Glu Val 
            20                  25                  30          


Met Lys Cys Ile Val Glu Val Ile Ser Asp Xaa Leu Ser Lys Pro Ser 
        35                  40                  45              


Pro Met Pro Val Ser Gln Glu Cys Phe Glu Xaa Leu Arg Gly Asp Glu 
    50                  55                  60                  


Arg Ile Leu Ser Ile Leu Arg His Gln Asn Leu Leu Lys Glu Leu Gln 
65                  70                  75                  80  


Asp Leu Ala Leu Gln Gly Ala Lys Glu Arg Ala His Gln Gln Lys Lys 
                85                  90                  95      


His Ser Gly Phe Glu Asp Glu Leu Ser Glu Val Leu Glu Asn Gln Ser 
            100                 105                 110         


Ser Gln Ala Glu Leu Lys Glu Ala Val Glu Glu Pro Ser Ser Lys Asp 
        115                 120                 125             


Val Met Glu Lys Arg Glu Asp Ser Lys Glu Ala Glu Lys Ser Gly Glu 
    130                 135                 140                 


Ala Xaa Asp Gly Ala Arg Pro Gln Ala Leu Pro Glu Pro Met Gln Glu 
145                 150                 155                 160 


Ser Lys Ala Glu Gly Asn Asn Gln Ala Pro Gly Glu Glu Glu Glu Glu 
                165                 170                 175     


Glu Glu Glu Ala Xaa Asn Xaa His Pro Pro Ala Ser Leu Pro Ser Gln 
            180                 185                 190         


Lys Tyr Pro Gly Pro Gln Ala Glu Gly Asp Ser Glu Gly Leu Ser Gln 
        195                 200                 205             


Gly Leu Val Asp Arg Glu Lys Gly Leu Ser Ala Glu Pro Gly Trp Gln 
    210                 215                 220                 


Ala Lys Arg Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Glu Ala Gly 
225                 230                 235                 240 


Glu Glu Ala Val Pro Glu Glu Glu Gly Pro Xaa Val Val Leu Asn Pro 
                245                 250                 255     


His Pro Ser Leu Gly Tyr Lys Glu Ile Arg Lys Gly Glu Ser Arg Ser 
            260                 265                 270         


Glu Ala Leu Ala Val Asp Gly Ala Gly Lys Pro Gly Ala Glu Glu Ala 
        275                 280                 285             


Gln Asp Pro Glu Gly Lys Gly Glu Gln Glu His Ser Gln Gln Lys Glu 
    290                 295                 300                 


Glu Glu Glu Glu Met Ala Val Val Pro Gln Gly Leu Phe Arg Gly Gly 
305                 310                 315                 320 


Lys Ser Gly Glu Leu Glu Gln Glu Glu Glu Arg Leu Ser Lys Glu Trp 
                325                 330                 335     


Glu Asp Ser Lys Arg Trp Ser Lys Met Asp Gln Leu Ala Lys Glu Leu 
            340                 345                 350         


Xaa Ala Glu Lys Arg Leu Glu Gly Gln Glu Glu Glu Glu Asp Asn Arg 
        355                 360                 365             


Asp Ser Ser Met Lys Leu Ser Phe Arg Ala Arg Ala Tyr Gly Phe Arg 
    370                 375                 380                 


Gly Pro Gly Pro Gln Leu Arg Arg Gly Trp Arg Pro Ser Ser Arg Glu 
385                 390                 395                 400 


Asp Ser Leu Glu Ala Gly Leu Pro Leu Gln Val Arg Gly Tyr Pro Glu 
                405                 410                 415     


Glu Lys Lys Glu Glu Glu Gly Ser Ala Asn Arg Arg Pro Glu Asp Gln 
            420                 425                 430         


Glu Leu Glu Ser Leu Ser Ala Ile Glu Ala Glu Leu Glu Lys Val Ala 
        435                 440                 445             


His Gln Leu Gln Ala Leu Arg Arg Gly 
    450                 455         


<210> 6062
<211> 306
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<400> 6062
Met Arg Ser Ala Ala Val Leu Ala Leu Leu Leu Cys Ala Gly Gln Val 
1               5                   10                  15      


Xaa Ala Leu Pro Val Asn Ser Pro Met Asn Lys Gly Asp Xaa Glu Val 
            20                  25                  30          


Met Lys Cys Ile Val Glu Val Ile Ser Asp Xaa Leu Ser Lys Pro Ser 
        35                  40                  45              


Pro Met Pro Val Ser Gln Glu Cys Phe Glu Xaa Leu Arg Gly Asp Glu 
    50                  55                  60                  


Arg Ile Leu Ser Ile Leu Arg His Gln Asn Leu Leu Lys Glu Leu Gln 
65                  70                  75                  80  


Asp Leu Ala Leu Gln Gly Ala Lys Glu Arg Ala His Gln Gln Lys Lys 
                85                  90                  95      


His Ser Gly Phe Glu Asp Glu Leu Ser Glu Val Leu Glu Asn Gln Ser 
            100                 105                 110         


Ser Gln Ala Glu Leu Lys Gly Arg Ser Glu Ala Leu Ala Val Asp Gly 
        115                 120                 125             


Ala Gly Lys Pro Gly Ala Glu Glu Ala Gln Asp Pro Glu Gly Lys Gly 
    130                 135                 140                 


Glu Gln Glu His Ser Gln Gln Lys Glu Glu Glu Glu Glu Met Ala Val 
145                 150                 155                 160 


Val Pro Gln Gly Leu Phe Arg Gly Gly Lys Ser Gly Glu Leu Glu Gln 
                165                 170                 175     


Glu Glu Glu Arg Leu Ser Lys Glu Trp Glu Asp Ser Lys Arg Trp Ser 
            180                 185                 190         


Lys Met Asp Gln Leu Ala Lys Glu Leu Xaa Ala Glu Lys Arg Leu Glu 
        195                 200                 205             


Gly Gln Glu Glu Glu Glu Asp Asn Arg Asp Ser Ser Met Lys Leu Ser 
    210                 215                 220                 


Phe Arg Ala Arg Ala Tyr Gly Phe Arg Gly Pro Gly Pro Gln Leu Arg 
225                 230                 235                 240 


Arg Gly Trp Arg Pro Ser Ser Arg Glu Asp Ser Leu Glu Ala Gly Leu 
                245                 250                 255     


Pro Leu Gln Val Arg Gly Tyr Pro Glu Glu Lys Lys Glu Glu Glu Gly 
            260                 265                 270         


Ser Ala Asn Arg Arg Pro Glu Asp Gln Glu Leu Glu Ser Leu Ser Ala 
        275                 280                 285             


Ile Glu Ala Glu Leu Glu Lys Val Ala His Gln Leu Gln Ala Leu Arg 
    290                 295                 300                 


Arg Gly 
305     


<210> 6063
<211> 383
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<400> 6063
Met Gly Val Lys Ala Ser Gln Xaa Gly Phe Val Val Leu Val Leu Leu 
1               5                   10                  15      


Gln Cys Cys Ser Ala Tyr Lys Leu Val Cys Tyr Tyr Xaa Ser Trp Ser 
            20                  25                  30          


Gln Tyr Arg Glu Gly Asp Gly Ser Cys Phe Pro Asp Ala Leu Asp Arg 
        35                  40                  45              


Phe Leu Cys Xaa His Ile Ile Tyr Ser Phe Ala Asn Ile Ser Asn Asp 
    50                  55                  60                  


His Ile Asp Xaa Trp Glu Trp Asn Asp Val Xaa Leu Tyr Gly Met Leu 
65                  70                  75                  80  


Asn Xaa Leu Lys Asn Arg Asn Pro Asn Leu Lys Xaa Leu Leu Ser Val 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Ser Gln Arg Phe Ser Lys Ile Ala Ser Asn 
            100                 105                 110         


Xaa Gln Ser Arg Arg Xaa Phe Ile Lys Ser Val Pro Pro Phe Leu Arg 
        115                 120                 125             


Xaa His Gly Phe Asp Gly Leu Asp Leu Ala Trp Leu Tyr Pro Gly Arg 
    130                 135                 140                 


Arg Asp Lys Gln His Phe Xaa Xaa Leu Ile Lys Glu Met Lys Ala Glu 
145                 150                 155                 160 


Phe Ile Lys Glu Ala Gln Pro Gly Lys Lys Gln Leu Leu Leu Ser Ala 
                165                 170                 175     


Ala Leu Ser Ala Gly Lys Val Xaa Ile Asp Ser Ser Tyr Asp Ile Ala 
            180                 185                 190         


Lys Ile Ser Gln His Leu Asp Phe Ile Ser Ile Met Xaa Tyr Asp Phe 
        195                 200                 205             


His Gly Ala Trp Arg Gly Xaa Xaa Gly His His Ser Pro Leu Phe Arg 
    210                 215                 220                 


Gly Gln Glu Asp Ala Ser Pro Asp Arg Phe Ser Asn Xaa Asp Tyr Ala 
225                 230                 235                 240 


Val Gly Tyr Met Leu Arg Leu Gly Ala Pro Ala Ser Lys Leu Val Met 
                245                 250                 255     


Gly Ile Pro Xaa Phe Gly Arg Ser Phe Xaa Leu Ala Ser Ser Glu Xaa 
            260                 265                 270         


Gly Val Gly Ala Pro Ile Ser Gly Pro Gly Ile Pro Gly Arg Phe Xaa 
        275                 280                 285             


Lys Glu Ala Gly Xaa Leu Ala Tyr Tyr Glu Ile Cys Asp Phe Leu Arg 
    290                 295                 300                 


Gly Ala Xaa Val His Arg Ile Leu Gly Gln Gln Val Pro Tyr Ala Xaa 
305                 310                 315                 320 


Lys Gly Asn Gln Trp Val Gly Tyr Asp Asp Gln Glu Ser Val Lys Ser 
                325                 330                 335     


Lys Val Gln Tyr Leu Lys Asp Arg Gln Leu Ala Gly Ala Met Val Trp 
            340                 345                 350         


Ala Leu Asp Leu Asp Asp Phe Gln Gly Ser Phe Cys Gly Gln Asp Leu 
        355                 360                 365             


Arg Phe Pro Leu Xaa Asn Ala Ile Lys Asp Ala Leu Ala Ala Xaa 
    370                 375                 380             


<210> 6064
<211> 152
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<400> 6064
Xaa Leu Leu Leu Ser Ala Ala Leu Ser Ala Gly Lys Val Xaa Ile Asp 
1               5                   10                  15      


Ser Ser Tyr Asp Ile Ala Lys Ile Ser Gln His Leu Asp Phe Ile Ser 
            20                  25                  30          


Ile Met Xaa Tyr Asp Phe His Gly Ala Trp Arg Gly Xaa Xaa Gly His 
        35                  40                  45              


His Ser Pro Leu Phe Arg Gly Gln Glu Asp Ala Ser Pro Asp Arg Phe 
    50                  55                  60                  


Ser Asn Xaa Ile Cys Asp Phe Leu Arg Gly Ala Xaa Val His Arg Ile 
65                  70                  75                  80  


Leu Gly Gln Gln Val Pro Tyr Ala Xaa Lys Gly Asn Gln Trp Val Gly 
                85                  90                  95      


Tyr Asp Asp Gln Glu Ser Val Lys Ser Lys Val Gln Tyr Leu Lys Asp 
            100                 105                 110         


Arg Gln Leu Ala Gly Ala Met Val Trp Ala Leu Asp Leu Asp Asp Phe 
        115                 120                 125             


Gln Gly Ser Phe Cys Gly Gln Asp Leu Arg Phe Pro Leu Xaa Asn Ala 
    130                 135                 140                 


Ile Lys Asp Ala Leu Ala Ala Xaa 
145                 150         


<210> 6065
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<400> 6065
Ile Asp Phe Glu Tyr Ser Ser Tyr Asn Tyr Arg Gly Phe Asp Ile Gly 
1               5                   10                  15      


Asn His Phe Cys Glu Trp Met Tyr Asp Tyr Ser Tyr Glu Lys Tyr Pro 
            20                  25                  30          


Phe Phe Arg Ala Asn Ile Arg Lys Tyr Pro Xaa Lys Lys Gln Gln Leu 
        35                  40                  45              


His Phe Ile Ser Ser Tyr Leu Pro Ala Phe Gln Asn Asp Phe Glu Asn 
    50                  55                  60                  


Leu Ser Xaa Glu Glu Lys Ser Ile Ile Lys Glu Glu Met Leu Leu Glu 
65                  70                  75                  80  


Val Asn Arg Phe Ala Leu Ala Ser His Phe Leu Trp Gly Leu Trp Ser 
                85                  90                  95      


Ile Val Gln Ala Lys Ile Ser Ser Ile Glu Phe Gly Tyr Met Tyr Pro 
            100                 105                 110         


Asn Val Val Xaa Trp Trp His Gln Asp Ser Val Ala Gln Pro Arg Lys 
        115                 120                 125             


Pro Gly Glu Lys Pro Leu Ser Leu Met Leu Trp Leu Pro Leu Glu Val 
    130                 135                 140                 


Ala Leu Xaa Ser Arg Pro Ala Asp Leu Ala Ser Pro Ala Ser Glu Lys 
145                 150                 155                 160 


Cys Leu Gln Ser 
                


<210> 6066
<211> 439
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<400> 6066
Met Lys Xaa Lys Phe Cys Xaa Gly Gly Glu Ala Glu Pro Ser Pro Leu 
1               5                   10                  15      


Gly Leu Leu Leu Ser Cys Gly Ser Gly Ser Ala Ala Pro Ala Pro Gly 
            20                  25                  30          


Val Gly Gln Gln Arg Asp Ala Ala Ser Asp Leu Glu Ser Lys Gln Leu 
        35                  40                  45              


Gly Gly Gln Gln Pro Pro Leu Ala Leu Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Leu Pro Leu Pro Leu Pro Gln Pro Pro Pro Pro Gln Pro Pro Ala Asp 
65                  70                  75                  80  


Glu Gln Pro Glu Pro Arg Xaa Arg Arg Arg Ala Tyr Leu Trp Cys Lys 
                85                  90                  95      


Glu Phe Leu Pro Gly Ala Trp Arg Gly Leu Arg Glu Asp Glu Phe His 
            100                 105                 110         


Ile Ser Val Ile Arg Gly Gly Leu Ser Asn Met Leu Phe Gln Cys Ser 
        115                 120                 125             


Leu Pro Asp Xaa Xaa Ala Xaa Leu Gly Asp Glu Pro Arg Lys Val Leu 
    130                 135                 140                 


Leu Arg Leu Tyr Gly Ala Ile Leu Gln Met Gly Ala Glu Ala Met Val 
145                 150                 155                 160 


Leu Glu Ser Val Met Phe Ala Ile Leu Ala Glu Arg Ser Leu Gly Pro 
                165                 170                 175     


Lys Leu Tyr Gly Ile Phe Pro Gln Gly Arg Leu Glu Gln Phe Ile Pro 
            180                 185                 190         


Ser Arg Arg Leu Asp Xaa Glu Glu Leu Ser Leu Pro Asp Ile Ser Ala 
        195                 200                 205             


Glu Ile Ala Glu Lys Met Ala Xaa Phe His Gly Met Lys Met Pro Phe 
    210                 215                 220                 


Asn Lys Glu Pro Lys Trp Leu Phe Gly Xaa Met Glu Lys Tyr Leu Lys 
225                 230                 235                 240 


Glu Val Leu Arg Ile Lys Phe Xaa Glu Glu Ser Arg Ile Lys Lys Leu 
                245                 250                 255     


His Lys Leu Leu Ser Tyr Asn Leu Pro Leu Glu Leu Glu Asn Leu Arg 
            260                 265                 270         


Ser Leu Leu Glu Ser Xaa Pro Ser Pro Val Val Phe Cys His Asn Asp 
        275                 280                 285             


Cys Gln Glu Gly Asn Ile Leu Leu Leu Glu Gly Arg Glu Asn Ser Glu 
    290                 295                 300                 


Lys Gln Lys Leu Met Leu Ile Asp Phe Glu Tyr Ser Ser Tyr Asn Tyr 
305                 310                 315                 320 


Arg Gly Phe Asp Ile Gly Asn His Phe Cys Glu Trp Met Tyr Asp Tyr 
                325                 330                 335     


Ser Tyr Glu Lys Tyr Pro Phe Phe Arg Ala Asn Ile Arg Lys Tyr Pro 
            340                 345                 350         


Xaa Lys Lys Gln Gln Leu His Phe Ile Ser Ser Tyr Leu Pro Ala Phe 
        355                 360                 365             


Gln Asn Asp Phe Glu Asn Leu Ser Xaa Glu Glu Lys Ser Ile Ile Lys 
    370                 375                 380                 


Glu Glu Met Leu Leu Glu Val Asn Arg Phe Ala Leu Ala Ser His Phe 
385                 390                 395                 400 


Leu Trp Gly Leu Trp Ser Ile Val Gln Ala Lys Ile Ser Ser Ile Glu 
                405                 410                 415     


Phe Gly Tyr Met Asp Tyr Ala Gln Ala Arg Phe Asp Ala Tyr Phe His 
            420                 425                 430         


Gln Lys Arg Lys Leu Gly Val 
        435                 


<210> 6067
<211> 457
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<400> 6067
Met Lys Xaa Lys Phe Cys Xaa Gly Gly Glu Ala Glu Pro Ser Pro Leu 
1               5                   10                  15      


Gly Leu Leu Leu Ser Cys Gly Ser Gly Ser Ala Ala Pro Ala Pro Gly 
            20                  25                  30          


Val Gly Gln Gln Arg Asp Ala Ala Ser Asp Leu Glu Ser Lys Gln Leu 
        35                  40                  45              


Gly Gly Gln Gln Pro Pro Leu Ala Leu Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Leu Pro Leu Pro Leu Pro Gln Pro Pro Pro Pro Gln Pro Pro Ala Asp 
65                  70                  75                  80  


Glu Gln Pro Glu Pro Arg Xaa Arg Arg Arg Ala Tyr Leu Trp Cys Lys 
                85                  90                  95      


Glu Phe Leu Pro Gly Ala Trp Arg Gly Leu Arg Glu Asp Glu Phe His 
            100                 105                 110         


Ile Ser Val Ile Arg Gly Gly Leu Ser Asn Met Leu Phe Gln Cys Ser 
        115                 120                 125             


Leu Pro Asp Xaa Xaa Ala Xaa Leu Gly Asp Glu Pro Arg Lys Val Leu 
    130                 135                 140                 


Leu Arg Leu Tyr Gly Ala Ile Leu Gln Met Arg Ser Cys Asn Lys Glu 
145                 150                 155                 160 


Gly Ser Glu Gln Ala Gln Lys Glu Asn Glu Phe Gln Gly Ala Glu Ala 
                165                 170                 175     


Met Val Leu Glu Ser Val Met Phe Ala Ile Leu Ala Glu Arg Ser Leu 
            180                 185                 190         


Gly Pro Lys Leu Tyr Gly Ile Phe Pro Gln Gly Arg Leu Glu Gln Phe 
        195                 200                 205             


Ile Pro Ser Arg Arg Leu Asp Xaa Glu Glu Leu Ser Leu Pro Asp Ile 
    210                 215                 220                 


Ser Ala Glu Ile Ala Glu Lys Met Ala Xaa Phe His Gly Met Lys Met 
225                 230                 235                 240 


Pro Phe Asn Lys Glu Pro Lys Trp Leu Phe Gly Xaa Met Glu Lys Tyr 
                245                 250                 255     


Leu Lys Glu Val Leu Arg Ile Lys Phe Xaa Glu Glu Ser Arg Ile Lys 
            260                 265                 270         


Lys Leu His Lys Leu Leu Ser Tyr Asn Leu Pro Leu Glu Leu Glu Asn 
        275                 280                 285             


Leu Arg Ser Leu Leu Glu Ser Xaa Pro Ser Pro Val Val Phe Cys His 
    290                 295                 300                 


Asn Asp Cys Gln Glu Gly Asn Ile Leu Leu Leu Glu Gly Arg Glu Asn 
305                 310                 315                 320 


Ser Glu Lys Gln Lys Leu Met Leu Ile Asp Phe Glu Tyr Ser Ser Tyr 
                325                 330                 335     


Asn Tyr Arg Gly Phe Asp Ile Gly Asn His Phe Cys Glu Trp Met Tyr 
            340                 345                 350         


Asp Tyr Ser Tyr Glu Lys Tyr Pro Phe Phe Arg Ala Asn Ile Arg Lys 
        355                 360                 365             


Tyr Pro Xaa Lys Lys Gln Gln Leu His Phe Ile Ser Ser Tyr Leu Pro 
    370                 375                 380                 


Ala Phe Gln Asn Asp Phe Glu Asn Leu Ser Xaa Glu Glu Lys Ser Ile 
385                 390                 395                 400 


Ile Lys Glu Glu Met Leu Leu Glu Val Asn Arg Phe Ala Leu Ala Ser 
                405                 410                 415     


His Phe Leu Trp Gly Leu Trp Ser Ile Val Gln Ala Lys Ile Ser Ser 
            420                 425                 430         


Ile Glu Phe Gly Tyr Met Asp Tyr Ala Gln Ala Arg Phe Asp Ala Tyr 
        435                 440                 445             


Phe His Gln Lys Arg Lys Leu Gly Val 
    450                 455         


<210> 6068
<211> 156
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<400> 6068
Met Leu Phe Gln Cys Ser Leu Pro Asp Xaa Xaa Ala Xaa Leu Gly Asp 
1               5                   10                  15      


Glu Pro Arg Lys Val Leu Leu Arg Leu Tyr Gly Ala Ile Leu Gln Met 
            20                  25                  30          


Arg Ser Cys Asn Lys Glu Gly Ser Glu Gln Ala Gln Lys Glu Asn Glu 
        35                  40                  45              


Phe Gln Gly Ala Glu Ala Met Val Leu Glu Ser Val Met Phe Ala Ile 
    50                  55                  60                  


Leu Ala Glu Arg Ser Leu Gly Pro Lys Leu Tyr Gly Ile Phe Pro Gln 
65                  70                  75                  80  


Gly Arg Leu Glu Gln Phe Ile Pro Ser Arg Arg Leu Asp Xaa Glu Glu 
                85                  90                  95      


Leu Ser Leu Pro Asp Ile Ser Ala Glu Ile Ala Glu Lys Met Ala Xaa 
            100                 105                 110         


Phe His Gly Met Lys Met Pro Phe Asn Lys Glu Pro Lys Trp Leu Phe 
        115                 120                 125             


Gly Xaa Met Glu Lys Tyr Leu Lys Glu Val Leu Arg Ile Lys Phe Xaa 
    130                 135                 140                 


Glu Glu Ser Arg Ile Lys Lys Leu His Lys Leu Leu 
145                 150                 155     


<210> 6069
<211> 66
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 6069
Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe 
1               5                   10                  15      


Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln 
            20                  25                  30          


Gln Val Pro Xaa Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro 
        35                  40                  45              


Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu 
    50                  55                  60                  


Pro Xaa 
65      


<210> 6070
<211> 85
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<400> 6070
Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe 
1               5                   10                  15      


Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln 
            20                  25                  30          


Gln Val Pro Xaa Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro 
        35                  40                  45              


Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu 
    50                  55                  60                  


Pro Xaa Phe Ser Trp Xaa Lys Asp Gly Asn Pro Phe Tyr Phe Xaa Asp 
65                  70                  75                  80  


His Arg Ile Ile Pro 
                85  


<210> 6071
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<400> 6071
Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe 
1               5                   10                  15      


Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln 
            20                  25                  30          


Gln Val Pro Xaa Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro 
        35                  40                  45              


Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu 
    50                  55                  60                  


Pro Xaa Phe Ser Trp Xaa Lys Asp Gly Asn Pro Phe Tyr Phe Xaa Asp 
65                  70                  75                  80  


His Arg Ile Ile Pro Ser Asn Asn Ser Gly Xaa Phe Arg Ile Pro Asn 
                85                  90                  95      


<210> 6072
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<400> 6072
Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe 
1               5                   10                  15      


Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln 
            20                  25                  30          


Gln Val Pro Xaa Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro 
        35                  40                  45              


Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu 
    50                  55                  60                  


Pro Xaa Phe Ser Trp Xaa Lys Asp Gly Asn Pro Phe Tyr Phe Xaa Asp 
65                  70                  75                  80  


His Arg Ile Ile Pro Ser Asn Asn Ser Gly Xaa Phe Arg Ile Pro Asn 
                85                  90                  95      


Glu Gly His Ile Ser His Phe Gln Gly Lys Tyr Arg Cys Phe Ala Ser 
            100                 105                 110         


Asn Lys Leu Gly Ile Ala Met Ser Glu Glu Ile Glu Phe Ile Val Pro 
        115                 120                 125             


Ser Val Pro Lys Phe Pro Lys Glu Lys Ile Asp Pro Leu Glu Val Glu 
    130                 135                 140                 


Glu Gly Asp Pro Ile Val Leu Pro Cys Asn Pro Pro Lys Gly Leu Pro 
145                 150                 155                 160 


Pro Leu His Ile Tyr Trp Met Asn Ile Glu Leu Glu His Ile Glu Gln 
                165                 170                 175     


Asp Glu Arg Val Tyr 
            180     


<210> 6073
<211> 1171
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<400> 6073
Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe 
1               5                   10                  15      


Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln 
            20                  25                  30          


Gln Val Pro Xaa Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro 
        35                  40                  45              


Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu 
    50                  55                  60                  


Pro Xaa Phe Ser Trp Xaa Lys Asp Gly Asn Pro Phe Tyr Phe Xaa Asp 
65                  70                  75                  80  


His Arg Ile Ile Pro Ser Asn Asn Ser Gly Xaa Phe Arg Ile Pro Asn 
                85                  90                  95      


Glu Gly His Ile Ser His Phe Gln Gly Lys Tyr Arg Cys Phe Ala Ser 
            100                 105                 110         


Asn Lys Leu Gly Ile Ala Met Ser Glu Glu Ile Glu Phe Ile Val Pro 
        115                 120                 125             


Ser Val Pro Lys Phe Pro Lys Glu Lys Ile Asp Pro Leu Glu Val Glu 
    130                 135                 140                 


Glu Gly Asp Pro Ile Val Leu Pro Cys Asn Pro Pro Lys Gly Leu Pro 
145                 150                 155                 160 


Pro Leu His Ile Tyr Trp Met Asn Ile Glu Leu Glu His Ile Glu Gln 
                165                 170                 175     


Asp Glu Arg Val Tyr Met Ser Gln Lys Gly Asp Leu Tyr Phe Ala Asn 
            180                 185                 190         


Val Glu Glu Lys Asp Ser Arg Asn Asp Tyr Cys Cys Phe Ala Ala Phe 
        195                 200                 205             


Pro Arg Leu Arg Xaa Ile Val Gln Lys Met Pro Met Lys Leu Xaa Val 
    210                 215                 220                 


Asn Ser Leu Lys His Ala Asn Asp Ser Ser Ser Ser Xaa Glu Ile Gly 
225                 230                 235                 240 


Ser Lys Ala Asn Ser Ile Lys Gln Arg Lys Pro Lys Leu Leu Leu Pro 
                245                 250                 255     


Pro Xaa Glu Ser Gly Ser Glu Ser Ser Ile Xaa Ile Leu Lys Gly Glu 
            260                 265                 270         


Ile Leu Leu Leu Glu Cys Phe Ala Glu Gly Leu Pro Xaa Pro Gln Val 
        275                 280                 285             


Asp Trp Asn Lys Ile Gly Gly Asp Leu Pro Lys Gly Arg Glu Xaa Lys 
    290                 295                 300                 


Glu Asn Tyr Gly Lys Xaa Leu Lys Ile Glu Asn Val Ser Tyr Gln Asp 
305                 310                 315                 320 


Lys Gly Asn Tyr Arg Cys Xaa Ala Ser Asn Phe Leu Gly Xaa Ala Xaa 
                325                 330                 335     


His Asp Phe His Val Ile Val Glu Glu Pro Pro Arg Trp Xaa Lys Lys 
            340                 345                 350         


Pro Gln Ser Ala Val Tyr Ser Xaa Gly Ser Asn Gly Ile Leu Leu Cys 
        355                 360                 365             


Glu Ala Glu Gly Glu Pro Gln Pro Xaa Ile Lys Trp Arg Val Asn Gly 
    370                 375                 380                 


Ser Pro Val Asp Asn His Pro Phe Ala Gly Asp Val Val Phe Pro Arg 
385                 390                 395                 400 


Glu Ile Ser Phe Xaa Asn Leu Gln Pro Asn His Xaa Ala Val Tyr Gln 
                405                 410                 415     


Cys Glu Ala Ser Asn Val His Gly Xaa Ile Leu Ala Asn Ala Asn Ile 
            420                 425                 430         


Asp Val Val Asp Val Arg Pro Leu Ile Gln Xaa Lys Asp Gly Glu Asn 
        435                 440                 445             


Tyr Ala Xaa Val Val Gly Tyr Ser Ala Phe Leu His Cys Glu Phe Phe 
    450                 455                 460                 


Ala Ser Pro Glu Ala Val Val Ser Trp Gln Lys Val Glu Glu Val Lys 
465                 470                 475                 480 


Pro Leu Glu Gly Arg Arg Tyr His Ile Tyr Glu Asn Gly Xaa Leu Gln 
                485                 490                 495     


Ile Asn Arg Xaa Xaa Glu Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val 
            500                 505                 510         


Glu Asn Ala Ile Gly Lys Xaa Ala Val Xaa Ala Asn Leu Asp Ile Arg 
        515                 520                 525             


Asn Ala Xaa Lys Leu Arg Val Ser Pro Lys Asn Pro Arg Ile Pro Lys 
    530                 535                 540                 


Leu His Met Leu Glu Leu His Cys Glu Ser Lys Cys Asp Ser His Leu 
545                 550                 555                 560 


Lys His Ser Leu Lys Leu Ser Trp Ser Lys Asp Gly Glu Ala Phe Glu 
                565                 570                 575     


Ile Asn Gly Xaa Glu Asp Gly Arg Ile Ile Ile Asp Gly Ala Asn Leu 
            580                 585                 590         


Xaa Ile Ser Asn Val Xaa Leu Glu Asp Gln Gly Ile Tyr Cys Cys Ser 
        595                 600                 605             


Ala His Xaa Ala Leu Asp Ser Ala Ala Asp Ile Xaa Gln Val Xaa Val 
    610                 615                 620                 


Leu Asp Val Pro Asp Pro Pro Glu Asn Leu His Leu Ser Glu Arg Gln 
625                 630                 635                 640 


Asn Arg Ser Val Arg Leu Xaa Trp Glu Ala Gly Ala Asp His Asn Ser 
                645                 650                 655     


Asn Ile Ser Glu Tyr Ile Val Glu Phe Glu Gly Asn Lys Glu Glu Pro 
            660                 665                 670         


Gly Arg Trp Glu Glu Leu Xaa Arg Val Gln Gly Lys Lys Xaa Xaa Val 
        675                 680                 685             


Ile Leu Pro Leu Ala Pro Phe Val Arg Tyr Gln Phe Arg Val Ile Ala 
    690                 695                 700                 


Val Asn Glu Val Gly Arg Ser Gln Pro Ser Gln Pro Ser Asp His His 
705                 710                 715                 720 


Glu Xaa Pro Pro Ala Ala Pro Asp Arg Asn Pro Gln Asn Ile Arg Val 
                725                 730                 735     


Gln Ala Ser Gln Pro Lys Glu Met Ile Ile Lys Trp Glu Pro Leu Lys 
            740                 745                 750         


Ser Met Glu Gln Asn Gly Pro Gly Leu Glu Tyr Arg Val Xaa Trp Lys 
        755                 760                 765             


Pro Gln Gly Ala Pro Val Glu Trp Glu Glu Glu Xaa Val Xaa Asn His 
    770                 775                 780                 


Xaa Leu Arg Val Met Xaa Pro Ala Val Tyr Ala Pro Tyr Asp Val Lys 
785                 790                 795                 800 


Val Gln Ala Ile Asn Gln Leu Gly Ser Gly Pro Asp Pro Gln Ser Val 
                805                 810                 815     


Xaa Leu Tyr Ser Gly Glu Asp Tyr Pro Asp Xaa Ala Pro Val Ile His 
            820                 825                 830         


Gly Val Asp Val Ile Asn Ser Xaa Leu Val Lys Val Xaa Trp Ser Xaa 
        835                 840                 845             


Val Pro Lys Asp Arg Val His Gly Arg Leu Lys Gly Tyr Gln Ile Asn 
    850                 855                 860                 


Trp Trp Lys Xaa Lys Ser Leu Leu Asp Gly Arg Xaa His Pro Lys Glu 
865                 870                 875                 880 


Val Asn Ile Leu Arg Phe Ser Gly Gln Arg Asn Ser Gly Met Val Pro 
                885                 890                 895     


Ser Leu Asp Ala Phe Ser Glu Phe His Leu Xaa Val Leu Ala Tyr Asn 
            900                 905                 910         


Ser Lys Gly Ala Gly Pro Glu Ser Glu Pro Tyr Ile Phe Gln Xaa Pro 
        915                 920                 925             


Glu Gly Val Pro Glu Gln Pro Xaa Phe Leu Lys Val Ile Lys Val Asp 
    930                 935                 940                 


Lys Asp Xaa Ala Xaa Leu Ser Trp Gly Leu Pro Lys Lys Leu Asn Gly 
945                 950                 955                 960 


Asn Leu Xaa Gly Tyr Leu Leu Gln Tyr Gln Ile Ile Asn Asp Xaa Tyr 
                965                 970                 975     


Glu Ile Gly Glu Leu Asn Asp Ile Asn Ile Xaa Xaa Pro Ser Lys Pro 
            980                 985                 990         


Ser Trp His Leu Ser Asn Leu Asn  Ala Xaa Xaa Lys Tyr  Lys Phe Tyr 
        995                 1000                 1005             


Leu Arg  Ala Cys Xaa Ser Gln  Gly Cys Gly Lys Pro  Ile Xaa Glu 
    1010                 1015                 1020             


Glu Ser  Ser Xaa Leu Gly Glu  Gly Lys Tyr Ala Gly  Leu Tyr Asp 
    1025                 1030                 1035             


Asp Ile  Ser Xaa Gln Gly Trp  Phe Ile Gly Leu Met  Cys Ala Ile 
    1040                 1045                 1050             


Ala Leu  Leu Xaa Leu Leu Leu  Leu Xaa Val Cys Phe  Val Lys Arg 
    1055                 1060                 1065             


Asn Arg  Gly Gly Lys Tyr Ser  Val Lys Glu Lys Glu  Asp Leu His 
    1070                 1075                 1080             


Pro Asp  Pro Glu Ile Gln Ser  Val Lys Asp Glu Xaa  Phe Gly Glu 
    1085                 1090                 1095             


Tyr Ser  Asp Ser Asp Glu Lys  Pro Leu Lys Gly Ser  Leu Arg Ser 
    1100                 1105                 1110             


Leu Asn  Arg Asp Met Gln Pro  Xaa Glu Ser Ala Asp  Ser Leu Val 
    1115                 1120                 1125             


Glu Tyr  Gly Glu Gly Asp His  Gly Leu Phe Ser Glu  Asp Gly Ser 
    1130                 1135                 1140             


Phe Ile  Gly Ala Tyr Ala Gly  Ser Lys Glu Lys Gly  Ser Val Glu 
    1145                 1150                 1155             


Ser Asn  Gly Ser Ser Xaa Ala  Xaa Phe Pro Leu Arg  Ala 
    1160                 1165                 1170     


<210> 6074
<211> 1224
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1219)..(1219)
<223> Selenocysteine

<400> 6074
Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe 
1               5                   10                  15      


Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln 
            20                  25                  30          


Gln Val Pro Xaa Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro 
        35                  40                  45              


Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu 
    50                  55                  60                  


Pro Xaa Phe Ser Trp Xaa Lys Asp Gly Asn Pro Phe Tyr Phe Xaa Asp 
65                  70                  75                  80  


His Arg Ile Ile Pro Ser Asn Asn Ser Gly Xaa Phe Arg Ile Pro Asn 
                85                  90                  95      


Glu Gly His Ile Ser His Phe Gln Gly Lys Tyr Arg Cys Phe Ala Ser 
            100                 105                 110         


Asn Lys Leu Gly Ile Ala Met Ser Glu Glu Ile Glu Phe Ile Val Pro 
        115                 120                 125             


Ser Val Pro Lys Phe Pro Lys Glu Lys Ile Asp Pro Leu Glu Val Glu 
    130                 135                 140                 


Glu Gly Asp Pro Ile Val Leu Pro Cys Asn Pro Pro Lys Gly Leu Pro 
145                 150                 155                 160 


Pro Leu His Ile Tyr Trp Met Asn Ile Glu Leu Glu His Ile Glu Gln 
                165                 170                 175     


Asp Glu Arg Val Tyr Met Ser Gln Lys Gly Asp Leu Tyr Phe Ala Asn 
            180                 185                 190         


Val Glu Glu Lys Asp Ser Arg Asn Asp Tyr Cys Cys Phe Ala Ala Phe 
        195                 200                 205             


Pro Arg Leu Arg Xaa Ile Val Gln Lys Met Pro Met Lys Leu Xaa Val 
    210                 215                 220                 


Asn Ser Leu Lys His Ala Asn Asp Ser Ser Ser Ser Xaa Glu Ile Gly 
225                 230                 235                 240 


Ser Lys Ala Asn Ser Ile Lys Gln Arg Lys Pro Lys Leu Leu Leu Pro 
                245                 250                 255     


Pro Xaa Glu Ser Gly Ser Glu Ser Ser Ile Xaa Ile Leu Lys Gly Glu 
            260                 265                 270         


Ile Leu Leu Leu Glu Cys Phe Ala Glu Gly Leu Pro Xaa Pro Gln Val 
        275                 280                 285             


Asp Trp Asn Lys Ile Gly Gly Asp Leu Pro Lys Gly Arg Glu Xaa Lys 
    290                 295                 300                 


Glu Asn Tyr Gly Lys Xaa Leu Lys Ile Glu Asn Val Ser Tyr Gln Asp 
305                 310                 315                 320 


Lys Gly Asn Tyr Arg Cys Xaa Ala Ser Asn Phe Leu Gly Xaa Ala Xaa 
                325                 330                 335     


His Asp Phe His Val Ile Val Glu Glu Pro Pro Arg Trp Xaa Lys Lys 
            340                 345                 350         


Pro Gln Ser Ala Val Tyr Ser Xaa Gly Ser Asn Gly Ile Leu Leu Cys 
        355                 360                 365             


Glu Ala Glu Gly Glu Pro Gln Pro Xaa Ile Lys Trp Arg Val Asn Gly 
    370                 375                 380                 


Ser Pro Val Asp Asn His Pro Phe Ala Gly Asp Val Val Phe Pro Arg 
385                 390                 395                 400 


Glu Ile Ser Phe Xaa Asn Leu Gln Pro Asn His Xaa Ala Val Tyr Gln 
                405                 410                 415     


Cys Glu Ala Ser Asn Val His Gly Xaa Ile Leu Ala Asn Ala Asn Ile 
            420                 425                 430         


Asp Val Val Asp Val Arg Pro Leu Ile Gln Xaa Lys Asp Gly Glu Asn 
        435                 440                 445             


Tyr Ala Xaa Val Val Gly Tyr Ser Ala Phe Leu His Cys Glu Phe Phe 
    450                 455                 460                 


Ala Ser Pro Glu Ala Val Val Ser Trp Gln Lys Val Glu Glu Val Lys 
465                 470                 475                 480 


Pro Leu Glu Gly Arg Arg Tyr His Ile Tyr Glu Asn Gly Xaa Leu Gln 
                485                 490                 495     


Ile Asn Arg Xaa Xaa Glu Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val 
            500                 505                 510         


Glu Asn Ala Ile Gly Lys Xaa Ala Val Xaa Ala Asn Leu Asp Ile Arg 
        515                 520                 525             


Asn Ala Xaa Lys Leu Arg Val Ser Pro Lys Asn Pro Arg Ile Pro Lys 
    530                 535                 540                 


Leu His Met Leu Glu Leu His Cys Glu Ser Lys Cys Asp Ser His Leu 
545                 550                 555                 560 


Lys His Ser Leu Lys Leu Ser Trp Ser Lys Asp Gly Glu Ala Phe Glu 
                565                 570                 575     


Ile Asn Gly Xaa Glu Asp Gly Arg Ile Ile Ile Asp Gly Ala Asn Leu 
            580                 585                 590         


Xaa Ile Ser Asn Val Xaa Leu Glu Asp Gln Gly Ile Tyr Cys Cys Ser 
        595                 600                 605             


Ala His Xaa Ala Leu Asp Ser Ala Ala Asp Ile Xaa Gln Val Xaa Val 
    610                 615                 620                 


Leu Asp Val Pro Asp Pro Pro Glu Asn Leu His Leu Ser Glu Arg Gln 
625                 630                 635                 640 


Asn Arg Ser Val Arg Leu Xaa Trp Glu Ala Gly Ala Asp His Asn Ser 
                645                 650                 655     


Asn Ile Ser Glu Tyr Ile Val Glu Phe Glu Gly Asn Lys Glu Glu Pro 
            660                 665                 670         


Gly Arg Trp Glu Glu Leu Xaa Arg Val Gln Gly Lys Lys Xaa Xaa Val 
        675                 680                 685             


Ile Leu Pro Leu Ala Pro Phe Val Arg Tyr Gln Phe Arg Val Ile Ala 
    690                 695                 700                 


Val Asn Glu Val Gly Arg Ser Gln Pro Ser Gln Pro Ser Asp His His 
705                 710                 715                 720 


Glu Xaa Pro Pro Ala Ala Pro Asp Arg Asn Pro Gln Asn Ile Arg Val 
                725                 730                 735     


Gln Ala Ser Gln Pro Lys Glu Met Ile Ile Lys Trp Glu Pro Leu Lys 
            740                 745                 750         


Ser Met Glu Gln Asn Gly Pro Gly Leu Glu Tyr Arg Val Xaa Trp Lys 
        755                 760                 765             


Pro Gln Gly Ala Pro Val Glu Trp Glu Glu Glu Xaa Val Xaa Asn His 
    770                 775                 780                 


Xaa Leu Arg Val Met Xaa Pro Ala Val Tyr Ala Pro Tyr Asp Val Lys 
785                 790                 795                 800 


Val Gln Ala Ile Asn Gln Leu Gly Ser Gly Pro Asp Pro Gln Ser Val 
                805                 810                 815     


Xaa Leu Tyr Ser Gly Glu Asp Tyr Pro Asp Xaa Ala Pro Val Ile His 
            820                 825                 830         


Gly Val Asp Val Ile Asn Ser Xaa Leu Val Lys Val Xaa Trp Ser Xaa 
        835                 840                 845             


Val Pro Lys Asp Arg Val His Gly Arg Leu Lys Gly Tyr Gln Ile Asn 
    850                 855                 860                 


Trp Trp Lys Xaa Lys Ser Leu Leu Asp Gly Arg Xaa His Pro Lys Glu 
865                 870                 875                 880 


Val Asn Ile Leu Arg Phe Ser Gly Gln Arg Asn Ser Gly Met Val Pro 
                885                 890                 895     


Ser Leu Asp Ala Phe Ser Glu Phe His Leu Xaa Val Leu Ala Tyr Asn 
            900                 905                 910         


Ser Lys Gly Ala Gly Pro Glu Ser Glu Pro Tyr Ile Phe Gln Xaa Pro 
        915                 920                 925             


Glu Gly Val Pro Glu Gln Pro Xaa Phe Leu Lys Val Ile Lys Val Asp 
    930                 935                 940                 


Lys Asp Xaa Ala Xaa Leu Ser Trp Gly Leu Pro Lys Lys Leu Asn Gly 
945                 950                 955                 960 


Asn Leu Xaa Gly Tyr Leu Leu Gln Tyr Gln Ile Ile Asn Asp Xaa Tyr 
                965                 970                 975     


Glu Ile Gly Glu Leu Asn Asp Ile Asn Ile Xaa Xaa Pro Ser Lys Pro 
            980                 985                 990         


Ser Trp His Leu Ser Asn Leu Asn  Ala Xaa Xaa Lys Tyr  Lys Phe Tyr 
        995                 1000                 1005             


Leu Arg  Ala Cys Xaa Ser Gln  Gly Cys Gly Lys Pro  Ile Xaa Glu 
    1010                 1015                 1020             


Glu Ser  Ser Xaa Leu Gly Glu  Gly Ser Lys Gly Ile  Gly Lys Ile 
    1025                 1030                 1035             


Ser Gly  Val Asn Leu Xaa Gln  Lys Xaa His Pro Ile  Glu Val Phe 
    1040                 1045                 1050             


Glu Pro  Gly Ala Glu His Ile  Val Arg Leu Met Xaa  Lys Asn Trp 
    1055                 1060                 1065             


Gly Asp  Asn Asp Ser Ile Phe  Gln Asp Val Ile Glu  Xaa Arg Gly 
    1070                 1075                 1080             


Arg Glu  Tyr Ala Gly Leu Tyr  Asp Asp Ile Ser Xaa  Gln Gly Trp 
    1085                 1090                 1095             


Phe Ile  Gly Leu Met Cys Ala  Ile Ala Leu Leu Xaa  Leu Leu Leu 
    1100                 1105                 1110             


Leu Xaa  Val Cys Phe Val Lys  Arg Asn Arg Gly Gly  Lys Tyr Ser 
    1115                 1120                 1125             


Val Lys  Glu Lys Glu Asp Leu  His Pro Asp Pro Glu  Ile Gln Ser 
    1130                 1135                 1140             


Val Lys  Asp Glu Xaa Phe Gly  Glu Tyr Ser Asp Ser  Asp Glu Lys 
    1145                 1150                 1155             


Pro Leu  Lys Gly Ser Leu Arg  Ser Leu Asn Arg Asp  Met Gln Pro 
    1160                 1165                 1170             


Xaa Glu  Ser Ala Asp Ser Leu  Val Glu Tyr Gly Glu  Gly Asp His 
    1175                 1180                 1185             


Gly Leu  Phe Ser Glu Asp Gly  Ser Phe Ile Gly Ala  Tyr Ala Gly 
    1190                 1195                 1200             


Ser Lys  Glu Lys Gly Ser Val  Glu Ser Asn Gly Ser  Ser Xaa Ala 
    1205                 1210                 1215             


Xaa Phe  Pro Leu Arg Ala 
    1220                 


<210> 6075
<211> 1208
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (920)..(920)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1158)..(1158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<400> 6075
Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe 
1               5                   10                  15      


Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln 
            20                  25                  30          


Gln Val Pro Xaa Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro 
        35                  40                  45              


Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu 
    50                  55                  60                  


Pro Xaa Phe Ser Trp Xaa Lys Asp Gly Asn Pro Phe Tyr Phe Xaa Asp 
65                  70                  75                  80  


His Arg Ile Ile Pro Ser Asn Asn Ser Gly Xaa Phe Arg Ile Pro Asn 
                85                  90                  95      


Glu Gly His Ile Ser His Phe Gln Gly Lys Tyr Arg Cys Phe Ala Ser 
            100                 105                 110         


Asn Lys Leu Gly Ile Ala Met Ser Glu Glu Ile Glu Phe Ile Val Pro 
        115                 120                 125             


Ser Val Pro Lys Phe Pro Lys Glu Lys Ile Asp Pro Leu Glu Val Glu 
    130                 135                 140                 


Glu Gly Asp Pro Ile Val Leu Pro Cys Asn Pro Pro Lys Gly Leu Pro 
145                 150                 155                 160 


Pro Leu His Ile Tyr Trp Met Asn Ile Glu Leu Glu His Ile Glu Gln 
                165                 170                 175     


Asp Glu Arg Val Tyr Met Ser Gln Lys Gly Asp Leu Tyr Phe Ala Asn 
            180                 185                 190         


Val Glu Glu Lys Asp Ser Arg Asn Asp Tyr Cys Cys Phe Ala Ala Phe 
        195                 200                 205             


Pro Arg Leu Arg Xaa Ile Val Gln Lys Met Pro Met Lys Leu Xaa Val 
    210                 215                 220                 


Asn Ser Ser Asn Ser Ile Lys Gln Arg Lys Pro Lys Leu Leu Leu Pro 
225                 230                 235                 240 


Pro Xaa Glu Ser Gly Ser Glu Ser Ser Ile Xaa Ile Leu Lys Gly Glu 
                245                 250                 255     


Ile Leu Leu Leu Glu Cys Phe Ala Glu Gly Leu Pro Xaa Pro Gln Val 
            260                 265                 270         


Asp Trp Asn Lys Ile Gly Gly Asp Leu Pro Lys Gly Arg Glu Xaa Lys 
        275                 280                 285             


Glu Asn Tyr Gly Lys Xaa Leu Lys Ile Glu Asn Val Ser Tyr Gln Asp 
    290                 295                 300                 


Lys Gly Asn Tyr Arg Cys Xaa Ala Ser Asn Phe Leu Gly Xaa Ala Xaa 
305                 310                 315                 320 


His Asp Phe His Val Ile Val Glu Glu Pro Pro Arg Trp Xaa Lys Lys 
                325                 330                 335     


Pro Gln Ser Ala Val Tyr Ser Xaa Gly Ser Asn Gly Ile Leu Leu Cys 
            340                 345                 350         


Glu Ala Glu Gly Glu Pro Gln Pro Xaa Ile Lys Trp Arg Val Asn Gly 
        355                 360                 365             


Ser Pro Val Asp Asn His Pro Phe Ala Gly Asp Val Val Phe Pro Arg 
    370                 375                 380                 


Glu Ile Ser Phe Xaa Asn Leu Gln Pro Asn His Xaa Ala Val Tyr Gln 
385                 390                 395                 400 


Cys Glu Ala Ser Asn Val His Gly Xaa Ile Leu Ala Asn Ala Asn Ile 
                405                 410                 415     


Asp Val Val Asp Val Arg Pro Leu Ile Gln Xaa Lys Asp Gly Glu Asn 
            420                 425                 430         


Tyr Ala Xaa Val Val Gly Tyr Ser Ala Phe Leu His Cys Glu Phe Phe 
        435                 440                 445             


Ala Ser Pro Glu Ala Val Val Ser Trp Gln Lys Val Glu Glu Val Lys 
    450                 455                 460                 


Pro Leu Glu Gly Arg Arg Tyr His Ile Tyr Glu Asn Gly Xaa Leu Gln 
465                 470                 475                 480 


Ile Asn Arg Xaa Xaa Glu Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val 
                485                 490                 495     


Glu Asn Ala Ile Gly Lys Xaa Ala Val Xaa Ala Asn Leu Asp Ile Arg 
            500                 505                 510         


Asn Ala Xaa Lys Leu Arg Val Ser Pro Lys Asn Pro Arg Ile Pro Lys 
        515                 520                 525             


Leu His Met Leu Glu Leu His Cys Glu Ser Lys Cys Asp Ser His Leu 
    530                 535                 540                 


Lys His Ser Leu Lys Leu Ser Trp Ser Lys Asp Gly Glu Ala Phe Glu 
545                 550                 555                 560 


Ile Asn Gly Xaa Glu Asp Gly Arg Ile Ile Ile Asp Gly Ala Asn Leu 
                565                 570                 575     


Xaa Ile Ser Asn Val Xaa Leu Glu Asp Gln Gly Ile Tyr Cys Cys Ser 
            580                 585                 590         


Ala His Xaa Ala Leu Asp Ser Ala Ala Asp Ile Xaa Gln Val Xaa Val 
        595                 600                 605             


Leu Asp Val Pro Asp Pro Pro Glu Asn Leu His Leu Ser Glu Arg Gln 
    610                 615                 620                 


Asn Arg Ser Val Arg Leu Xaa Trp Glu Ala Gly Ala Asp His Asn Ser 
625                 630                 635                 640 


Asn Ile Ser Glu Tyr Ile Val Glu Phe Glu Gly Asn Lys Glu Glu Pro 
                645                 650                 655     


Gly Arg Trp Glu Glu Leu Xaa Arg Val Gln Gly Lys Lys Xaa Xaa Val 
            660                 665                 670         


Ile Leu Pro Leu Ala Pro Phe Val Arg Tyr Gln Phe Arg Val Ile Ala 
        675                 680                 685             


Val Asn Glu Val Gly Arg Ser Gln Pro Ser Gln Pro Ser Asp His His 
    690                 695                 700                 


Glu Xaa Pro Pro Ala Ala Pro Asp Arg Asn Pro Gln Asn Ile Arg Val 
705                 710                 715                 720 


Gln Ala Ser Gln Pro Lys Glu Met Ile Ile Lys Trp Glu Pro Leu Lys 
                725                 730                 735     


Ser Met Glu Gln Asn Gly Pro Gly Leu Glu Tyr Arg Val Xaa Trp Lys 
            740                 745                 750         


Pro Gln Gly Ala Pro Val Glu Trp Glu Glu Glu Xaa Val Xaa Asn His 
        755                 760                 765             


Xaa Leu Arg Val Met Xaa Pro Ala Val Tyr Ala Pro Tyr Asp Val Lys 
    770                 775                 780                 


Val Gln Ala Ile Asn Gln Leu Gly Ser Gly Pro Asp Pro Gln Ser Val 
785                 790                 795                 800 


Xaa Leu Tyr Ser Gly Glu Asp Tyr Pro Asp Xaa Ala Pro Val Ile His 
                805                 810                 815     


Gly Val Asp Val Ile Asn Ser Xaa Leu Val Lys Val Xaa Trp Ser Xaa 
            820                 825                 830         


Val Pro Lys Asp Arg Val His Gly Arg Leu Lys Gly Tyr Gln Ile Asn 
        835                 840                 845             


Trp Trp Lys Xaa Lys Ser Leu Leu Asp Gly Arg Xaa His Pro Lys Glu 
    850                 855                 860                 


Val Asn Ile Leu Arg Phe Ser Gly Gln Arg Asn Ser Gly Met Val Pro 
865                 870                 875                 880 


Ser Leu Asp Ala Phe Ser Glu Phe His Leu Xaa Val Leu Ala Tyr Asn 
                885                 890                 895     


Ser Lys Gly Ala Gly Pro Glu Ser Glu Pro Tyr Ile Phe Gln Xaa Pro 
            900                 905                 910         


Glu Gly Val Pro Glu Gln Pro Xaa Phe Leu Lys Val Ile Lys Val Asp 
        915                 920                 925             


Lys Asp Xaa Ala Xaa Leu Ser Trp Gly Leu Pro Lys Lys Leu Asn Gly 
    930                 935                 940                 


Asn Leu Xaa Gly Tyr Leu Leu Gln Tyr Gln Ile Ile Asn Asp Xaa Tyr 
945                 950                 955                 960 


Glu Ile Gly Glu Leu Asn Asp Ile Asn Ile Xaa Xaa Pro Ser Lys Pro 
                965                 970                 975     


Ser Trp His Leu Ser Asn Leu Asn Ala Xaa Xaa Lys Tyr Lys Phe Tyr 
            980                 985                 990         


Leu Arg Ala Cys Xaa Ser Gln Gly  Cys Gly Lys Pro Ile  Xaa Glu Glu 
        995                 1000                 1005             


Ser Ser  Xaa Leu Gly Glu Gly  Ser Lys Gly Ile Gly  Lys Ile Ser 
    1010                 1015                 1020             


Gly Val  Asn Leu Xaa Gln Lys  Xaa His Pro Ile Glu  Val Phe Glu 
    1025                 1030                 1035             


Pro Gly  Ala Glu His Ile Val  Arg Leu Met Xaa Lys  Asn Trp Gly 
    1040                 1045                 1050             


Asp Asn  Asp Ser Ile Phe Gln  Asp Val Ile Glu Xaa  Arg Gly Arg 
    1055                 1060                 1065             


Glu Tyr  Ala Gly Leu Tyr Asp  Asp Ile Ser Xaa Gln  Gly Trp Phe 
    1070                 1075                 1080             


Ile Gly  Leu Met Cys Ala Ile  Ala Leu Leu Xaa Leu  Leu Leu Leu 
    1085                 1090                 1095             


Xaa Val  Cys Phe Val Lys Arg  Asn Arg Gly Gly Lys  Tyr Ser Val 
    1100                 1105                 1110             


Lys Glu  Lys Glu Asp Leu His  Pro Asp Pro Glu Ile  Gln Ser Val 
    1115                 1120                 1125             


Lys Asp  Glu Xaa Phe Gly Glu  Tyr Ser Asp Ser Asp  Glu Lys Pro 
    1130                 1135                 1140             


Leu Lys  Gly Ser Leu Arg Ser  Leu Asn Arg Asp Met  Gln Pro Xaa 
    1145                 1150                 1155             


Glu Ser  Ala Asp Ser Leu Val  Glu Tyr Gly Glu Gly  Asp His Gly 
    1160                 1165                 1170             


Leu Phe  Ser Glu Asp Gly Ser  Phe Ile Gly Ala Tyr  Ala Gly Ser 
    1175                 1180                 1185             


Lys Glu  Lys Gly Ser Val Glu  Ser Asn Gly Ser Ser  Xaa Ala Xaa 
    1190                 1195                 1200             


Phe Pro  Leu Arg Ala 
    1205             


<210> 6076
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<400> 6076
Met Pro Pro Ala Trp Ser Gly Glu Ser Met Asp Arg Gly Val Val Gly 
1               5                   10                  15      


Leu Gly Ser Xaa Lys Xaa Gln Arg Gly Ala Arg Ala Pro Pro Pro Gln 
            20                  25                  30          


Xaa Ala Glu Gly Arg Glu Gly Ala Pro Gly Ala Val Val Ala Met Ala 
        35                  40                  45              


Pro Gly Ser Gly Ala Arg Gly Ala Gly Asp Ala Gly Arg Gly Trp Ser 
    50                  55                  60                  


Leu Leu Pro Leu Cys Ala Ser Leu Phe Leu Ser Leu Phe Phe Phe Phe 
65                  70                  75                  80  


Trp Ser Val Ser Val Arg Gly Glu Ala Ala Arg Arg Lys 
                85                  90              


<210> 6077
<211> 358
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<400> 6077
Xaa Ser Val Xaa Leu Tyr Ser Gly Glu Asp Tyr Pro Asp Xaa Ala Pro 
1               5                   10                  15      


Val Ile His Gly Val Asp Val Ile Asn Ser Xaa Leu Val Lys Val Xaa 
            20                  25                  30          


Trp Ser Xaa Val Pro Lys Asp Arg Val His Gly Arg Leu Lys Gly Tyr 
        35                  40                  45              


Gln Ile Asn Trp Trp Lys Xaa Lys Ser Leu Leu Asp Gly Arg Xaa His 
    50                  55                  60                  


Pro Lys Glu Val Asn Ile Leu Arg Phe Ser Gly Gln Arg Asn Ser Gly 
65                  70                  75                  80  


Met Val Pro Ser Leu Asp Ala Phe Ser Glu Phe His Leu Xaa Val Leu 
                85                  90                  95      


Ala Tyr Asn Ser Lys Gly Ala Gly Pro Glu Ser Glu Pro Tyr Ile Phe 
            100                 105                 110         


Gln Xaa Pro Glu Gly Val Pro Glu Gln Pro Xaa Phe Leu Lys Val Ile 
        115                 120                 125             


Lys Val Asp Lys Asp Xaa Ala Xaa Leu Ser Trp Gly Leu Pro Lys Lys 
    130                 135                 140                 


Leu Asn Gly Asn Leu Xaa Gly Tyr Leu Leu Gln Tyr Gln Ile Ile Asn 
145                 150                 155                 160 


Asp Xaa Tyr Glu Ile Gly Glu Leu Asn Asp Ile Asn Ile Xaa Xaa Pro 
                165                 170                 175     


Ser Lys Pro Ser Trp His Leu Ser Asn Leu Asn Ala Xaa Xaa Lys Tyr 
            180                 185                 190         


Lys Phe Tyr Leu Arg Ala Cys Xaa Ser Gln Gly Cys Gly Lys Pro Ile 
        195                 200                 205             


Xaa Glu Glu Ser Ser Xaa Leu Gly Glu Gly Lys Tyr Ala Gly Leu Tyr 
    210                 215                 220                 


Asp Asp Ile Ser Xaa Gln Gly Trp Phe Ile Gly Leu Met Cys Ala Ile 
225                 230                 235                 240 


Ala Leu Leu Xaa Leu Leu Leu Leu Xaa Val Cys Phe Val Lys Arg Asn 
                245                 250                 255     


Arg Gly Gly Lys Tyr Ser Val Lys Glu Lys Glu Asp Leu His Pro Asp 
            260                 265                 270         


Pro Glu Ile Gln Ser Val Lys Asp Glu Xaa Phe Gly Glu Tyr Ser Asp 
        275                 280                 285             


Ser Asp Glu Lys Pro Leu Lys Gly Ser Leu Arg Ser Leu Asn Arg Asp 
    290                 295                 300                 


Met Gln Pro Xaa Glu Ser Ala Asp Ser Leu Val Glu Tyr Gly Glu Gly 
305                 310                 315                 320 


Asp His Gly Leu Phe Ser Glu Asp Gly Ser Phe Ile Gly Ala Tyr Ala 
                325                 330                 335     


Gly Ser Lys Glu Lys Gly Ser Val Glu Ser Asn Gly Ser Ser Xaa Ala 
            340                 345                 350         


Xaa Phe Pro Leu Arg Ala 
        355             


<210> 6078
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<400> 6078
Met Ala Asp Xaa Leu Pro Ser Glu Phe Asp Val Ile Val Ile Gly Xaa 
1               5                   10                  15      


Gly Leu Pro Glu Ser Ile Ile Ala Ala Ala Cys Ser Arg Ser Gly Arg 
            20                  25                  30          


Arg Val Leu His Val Asp Ser Arg Ser Tyr Tyr Gly Gly Asn Trp Ala 
        35                  40                  45              


Ser Phe Ser Phe Ser Gly Leu Leu Ser Trp Leu Lys Glu Tyr Gln Glu 
    50                  55                  60                  


Asn Ser Asp Ile Val Ser Asp Ser Pro Val Trp Gln Asp Gln Ile Leu 
65                  70                  75                  80  


Glu Asn Glu Glu Ala Ile Ala Leu Ser Arg Lys Asp Lys Xaa Ile Gln 
                85                  90                  95      


His Val Glu Val Phe Cys Tyr Ala Arg Ser Xaa Leu Leu Leu 
            100                 105                 110 


<210> 6079
<211> 653
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<400> 6079
Met Ala Asp Xaa Leu Pro Ser Glu Phe Asp Val Ile Val Ile Gly Xaa 
1               5                   10                  15      


Gly Leu Pro Glu Ser Ile Ile Ala Ala Ala Cys Ser Arg Ser Gly Arg 
            20                  25                  30          


Arg Val Leu His Val Asp Ser Arg Ser Tyr Tyr Gly Gly Asn Trp Ala 
        35                  40                  45              


Ser Phe Ser Phe Ser Gly Leu Leu Ser Trp Leu Lys Glu Tyr Gln Glu 
    50                  55                  60                  


Asn Ser Asp Ile Val Ser Asp Ser Pro Val Trp Gln Asp Gln Ile Leu 
65                  70                  75                  80  


Glu Asn Glu Glu Ala Ile Ala Leu Ser Arg Lys Asp Lys Xaa Ile Gln 
                85                  90                  95      


His Val Glu Val Phe Cys Tyr Ala Ser Gln Asp Leu His Glu Asp Val 
            100                 105                 110         


Glu Glu Ala Gly Ala Leu Gln Lys Asn His Ala Leu Val Xaa Ser Ala 
        115                 120                 125             


Asn Ser Xaa Glu Ala Ala Asp Ser Ala Phe Leu Pro Xaa Glu Asp Glu 
    130                 135                 140                 


Ser Leu Ser Xaa Met Ser Cys Glu Met Leu Xaa Glu Gln Xaa Pro Ser 
145                 150                 155                 160 


Ser Asp Pro Glu Asn Ala Leu Glu Val Asn Gly Ala Glu Val Xaa Gly 
                165                 170                 175     


Glu Lys Glu Asn His Cys Asp Asp Lys Xaa Cys Val Pro Ser Xaa Ser 
            180                 185                 190         


Ala Glu Asp Met Ser Glu Asn Val Pro Ile Ala Glu Asp Xaa Xaa Glu 
        195                 200                 205             


Gln Pro Lys Lys Asn Arg Ile Xaa Tyr Ser Gln Ile Ile Lys Glu Gly 
    210                 215                 220                 


Arg Arg Phe Asn Ile Asp Leu Val Ser Lys Leu Leu Tyr Ser Arg Gly 
225                 230                 235                 240 


Leu Leu Ile Asp Leu Leu Ile Lys Ser Asn Val Ser Arg Tyr Ala Glu 
                245                 250                 255     


Phe Lys Asn Ile Xaa Arg Ile Leu Ala Phe Arg Glu Gly Arg Val Glu 
            260                 265                 270         


Gln Val Pro Cys Ser Arg Ala Asp Val Phe Asn Ser Lys Gln Leu Xaa 
        275                 280                 285             


Met Val Glu Lys Arg Met Leu Met Lys Phe Leu Xaa Phe Cys Met Glu 
    290                 295                 300                 


Tyr Glu Lys Tyr Pro Asp Glu Tyr Lys Gly Tyr Glu Glu Ile Xaa Phe 
305                 310                 315                 320 


Tyr Glu Tyr Leu Lys Xaa Gln Lys Leu Xaa Pro Asn Leu Gln Tyr Ile 
                325                 330                 335     


Val Met His Ser Ile Ala Met Xaa Ser Glu Xaa Ala Ser Ser Xaa Ile 
            340                 345                 350         


Asp Gly Leu Lys Ala Xaa Lys Asn Phe Leu His Cys Leu Gly Arg Tyr 
        355                 360                 365             


Gly Asn Xaa Pro Phe Leu Phe Pro Leu Tyr Gly Gln Gly Glu Leu Pro 
    370                 375                 380                 


Gln Cys Phe Cys Arg Met Cys Ala Val Phe Gly Gly Ile Tyr Cys Leu 
385                 390                 395                 400 


Arg His Ser Val Gln Cys Leu Val Val Asp Lys Glu Ser Arg Lys Cys 
                405                 410                 415     


Lys Ala Ile Ile Asp Gln Phe Gly Gln Arg Ile Ile Ser Glu His Phe 
            420                 425                 430         


Leu Val Glu Asp Ser Tyr Phe Pro Glu Asn Met Cys Ser Arg Val Gln 
        435                 440                 445             


Tyr Arg Gln Ile Ser Arg Ala Val Leu Ile Xaa Asp Arg Ser Val Leu 
    450                 455                 460                 


Lys Xaa Asp Ser Asp Gln Gln Ile Ser Ile Leu Xaa Val Pro Ala Glu 
465                 470                 475                 480 


Glu Pro Gly Xaa Phe Ala Val Arg Val Ile Glu Leu Cys Ser Ser Xaa 
                485                 490                 495     


Met Xaa Cys Met Lys Gly Xaa Tyr Leu Val His Leu Xaa Cys Xaa Ser 
            500                 505                 510         


Ser Lys Xaa Ala Arg Glu Asp Leu Glu Ser Val Val Gln Lys Leu Phe 
        515                 520                 525             


Val Pro Tyr Xaa Glu Met Glu Ile Glu Asn Glu Gln Val Glu Lys Pro 
    530                 535                 540                 


Arg Ile Leu Trp Ala Leu Tyr Phe Asn Met Arg Asp Ser Ser Asp Ile 
545                 550                 555                 560 


Ser Arg Ser Cys Tyr Asn Asp Leu Pro Ser Asn Val Tyr Val Cys Ser 
                565                 570                 575     


Gly Pro Asp Cys Gly Leu Gly Asn Asp Asn Ala Val Lys Gln Ala Glu 
            580                 585                 590         


Xaa Leu Phe Gln Glu Ile Cys Pro Asn Glu Asp Phe Cys Pro Pro Pro 
        595                 600                 605             


Pro Asn Pro Glu Asp Ile Ile Leu Asp Gly Asp Ser Leu Gln Pro Glu 
    610                 615                 620                 


Ala Ser Glu Ser Ser Ala Ile Pro Glu Ala Asn Ser Glu Xaa Phe Lys 
625                 630                 635                 640 


Glu Ser Xaa Asn Leu Gly Asn Leu Glu Glu Ser Ser Glu 
                645                 650             


<210> 6080
<211> 100
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<400> 6080
Met Ala Asp Asn Leu Pro Xaa Glu Phe Asp Val Val Ile Ile Gly Xaa 
1               5                   10                  15      


Gly Leu Pro Glu Ser Ile Leu Ala Ala Ala Cys Ser Arg Ser Gly Gln 
            20                  25                  30          


Arg Val Leu His Ile Asp Ser Arg Ser Tyr Tyr Gly Gly Asn Trp Ala 
        35                  40                  45              


Ser Phe Ser Phe Ser Gly Leu Leu Ser Trp Leu Lys Glu Tyr Gln Gln 
    50                  55                  60                  


Asn Asn Asp Ile Gly Glu Glu Ser Xaa Val Val Trp Gln Asp Leu Ile 
65                  70                  75                  80  


His Glu Xaa Glu Glu Ala Ile Xaa Leu Arg Lys Lys Asp Glu Xaa Ile 
                85                  90                  95      


Gln His Xaa Glu 
            100 


<210> 6081
<211> 656
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<400> 6081
Met Ala Asp Asn Leu Pro Xaa Glu Phe Asp Val Val Ile Ile Gly Xaa 
1               5                   10                  15      


Gly Leu Pro Glu Ser Ile Leu Ala Ala Ala Cys Ser Arg Ser Gly Gln 
            20                  25                  30          


Arg Val Leu His Ile Asp Ser Arg Ser Tyr Tyr Gly Gly Asn Trp Ala 
        35                  40                  45              


Ser Phe Ser Phe Ser Gly Leu Leu Ser Trp Leu Lys Glu Tyr Gln Gln 
    50                  55                  60                  


Asn Asn Asp Ile Gly Glu Glu Ser Xaa Val Val Trp Gln Asp Leu Ile 
65                  70                  75                  80  


His Glu Xaa Glu Glu Ala Ile Xaa Leu Arg Lys Lys Asp Glu Xaa Ile 
                85                  90                  95      


Gln His Xaa Glu Ala Phe Cys Tyr Ala Ser Gln Asp Met Glu Asp Asn 
            100                 105                 110         


Val Glu Glu Ile Gly Ala Leu Gln Lys Asn Pro Ser Leu Gly Val Ser 
        115                 120                 125             


Asn Xaa Phe Xaa Glu Val Leu Asp Ser Ala Leu Pro Glu Glu Ser Gln 
    130                 135                 140                 


Leu Ser Tyr Phe Asn Ser Asp Glu Met Pro Ala Lys His Xaa Gln Lys 
145                 150                 155                 160 


Ser Asp Xaa Glu Ile Ser Leu Glu Val Xaa Asp Val Glu Glu Ser Val 
                165                 170                 175     


Glu Lys Glu Lys Tyr Cys Gly Asp Lys Xaa Cys Met His Xaa Val Ser 
            180                 185                 190         


Asp Lys Asp Gly Asp Lys Asp Glu Ser Lys Ser Xaa Val Glu Asp Lys 
        195                 200                 205             


Ala Asp Glu Pro Ile Arg Asn Arg Ile Xaa Tyr Ser Gln Ile Val Lys 
    210                 215                 220                 


Glu Gly Arg Arg Phe Asn Ile Asp Leu Val Ser Lys Leu Leu Tyr Ser 
225                 230                 235                 240 


Gln Gly Leu Leu Ile Asp Leu Leu Ile Lys Ser Asp Val Ser Arg Tyr 
                245                 250                 255     


Val Glu Phe Lys Asn Val Xaa Arg Ile Leu Ala Phe Arg Glu Gly Lys 
            260                 265                 270         


Val Glu Gln Val Pro Cys Ser Arg Ala Asp Val Phe Asn Ser Lys Glu 
        275                 280                 285             


Leu Xaa Met Val Glu Lys Arg Met Leu Met Lys Phe Leu Xaa Phe Cys 
    290                 295                 300                 


Leu Glu Tyr Glu Gln His Pro Asp Glu Tyr Gln Ala Phe Arg Gln Cys 
305                 310                 315                 320 


Ser Phe Ser Glu Tyr Leu Lys Xaa Lys Lys Leu Xaa Pro Asn Leu Gln 
                325                 330                 335     


His Phe Val Leu His Ser Ile Ala Met Xaa Ser Glu Ser Ser Cys Xaa 
            340                 345                 350         


Xaa Ile Asp Gly Leu Asn Ala Xaa Lys Asn Phe Leu Gln Cys Leu Gly 
        355                 360                 365             


Arg Phe Gly Asn Xaa Pro Phe Leu Phe Pro Leu Tyr Gly Gln Gly Glu 
    370                 375                 380                 


Ile Pro Gln Gly Phe Cys Arg Met Cys Ala Val Phe Gly Gly Ile Tyr 
385                 390                 395                 400 


Cys Leu Arg His Lys Val Gln Cys Phe Val Val Asp Lys Glu Ser Gly 
                405                 410                 415     


Arg Cys Lys Ala Ile Ile Asp His Phe Gly Gln Arg Ile Asn Ala Lys 
            420                 425                 430         


Tyr Phe Ile Val Glu Asp Ser Tyr Leu Ser Glu Glu Xaa Cys Ser Asn 
        435                 440                 445             


Val Gln Tyr Lys Gln Ile Ser Arg Ala Val Leu Ile Xaa Asp Gln Ser 
    450                 455                 460                 


Ile Leu Lys Xaa Asp Leu Asp Gln Gln Xaa Ser Ile Leu Ile Val Pro 
465                 470                 475                 480 


Pro Ala Glu Pro Gly Ala Cys Ala Val Arg Val Xaa Glu Leu Cys Ser 
                485                 490                 495     


Ser Xaa Met Xaa Cys Met Lys Asp Xaa Tyr Leu Val His Leu Xaa Cys 
            500                 505                 510         


Ser Ser Ser Lys Xaa Ala Arg Glu Asp Leu Glu Ser Val Val Lys Lys 
        515                 520                 525             


Leu Phe Xaa Pro Tyr Xaa Glu Xaa Glu Ile Asn Glu Glu Glu Leu Xaa 
    530                 535                 540                 


Lys Pro Arg Leu Leu Trp Ala Leu Tyr Phe Asn Met Arg Asp Ser Ser 
545                 550                 555                 560 


Gly Ile Ser Arg Ser Ser Tyr Asn Gly Leu Pro Ser Asn Val Tyr Val 
                565                 570                 575     


Cys Ser Gly Pro Asp Cys Gly Leu Gly Asn Glu His Ala Val Lys Gln 
            580                 585                 590         


Ala Glu Xaa Leu Phe Gln Glu Ile Phe Pro Xaa Glu Glu Phe Cys Pro 
        595                 600                 605             


Pro Pro Pro Asn Pro Glu Asp Ile Ile Phe Asp Gly Asp Asp Lys Gln 
    610                 615                 620                 


Pro Glu Ala Pro Gly Xaa Asn Asn Val Val Met Ala Lys Leu Glu Ser 
625                 630                 635                 640 


Ser Glu Glu Ser Lys Asn Leu Glu Ser Pro Glu Lys His Leu Gln Asn 
                645                 650                 655     


<210> 6082
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<400> 6082
Met Tyr Ser Gly Asn Arg Ser Gly Gly His Gly Tyr Trp Asp Gly Gly 
1               5                   10                  15      


Gly Ala Ala Gly Ala Glu Gly Pro Ala Pro Ala Gly Xaa Leu Ser Pro 
            20                  25                  30          


Ala Pro Leu Phe Ser Pro Gly Xaa Tyr Glu Arg Leu Ala Leu Leu Leu 
        35                  40                  45              


Gly Ser Ile Gly Leu Leu Gly Val Gly Asn Asn Leu Leu Val Leu Val 
    50                  55                  60                  


Leu Tyr Tyr Lys Phe Gln Arg Leu Arg Xaa Pro Xaa His Leu Leu Leu 
65                  70                  75                  80  


Val Asn Ile Ser Leu Ser Asp Leu Leu Val Ser Leu Phe Gly Val Xaa 
                85                  90                  95      


Phe Xaa Phe Val Ser Cys Leu Arg Asn Gly Trp Val Trp Asp Xaa Val 
            100                 105                 110         


Gly Cys Val Trp Asp Gly Phe Ser Gly Ser Leu Phe Ala Val Val Xaa 
        115                 120                 125             


Arg Arg Cys Tyr Phe Leu Lys Trp Arg Xaa Ile Phe Pro Gln Ser Leu 
    130                 135                 140                 


Met Trp Leu 
145         


<210> 6083
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 6083
Met Tyr Ser Gly Asn Arg Ser Gly Gly His Gly Tyr Trp Asp Gly Gly 
1               5                   10                  15      


Gly Ala Ala Gly Ala Glu Gly Pro Ala Pro Ala Gly Xaa Leu Ser Pro 
            20                  25                  30          


Ala Pro Leu Phe Ser Pro Gly Xaa Tyr Glu Arg Leu Ala Leu Leu Leu 
        35                  40                  45              


Gly Ser Ile Gly Leu Leu Gly Val Gly Asn Asn Leu Leu Val Leu Val 
    50                  55                  60                  


Leu Tyr Tyr Lys Phe Gln Arg Leu Arg Xaa Pro Xaa His Leu Leu Leu 
65                  70                  75                  80  


Val Asn Ile Ser Leu Ser Asp Leu Leu Val Ser Leu Phe Gly Val Xaa 
                85                  90                  95      


Phe Xaa Phe Val Ser Cys Leu Arg Asn Gly Trp Val Trp Asp Xaa Val 
            100                 105                 110         


Gly Cys Val Trp Asp Gly Phe Ser Gly Ser Leu Phe Glu Lys Ser Ser 
        115                 120                 125             


Ser His Lys Cys Ile Tyr Asp Ala Phe 
    130                 135         


<210> 6084
<211> 23
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<400> 6084
Met Ala Leu Xaa Leu Phe Asp Xaa Asp Glu Tyr Arg Pro Pro Val Trp 
1               5                   10                  15      


Lys Ser Tyr Cys Phe Met Ala 
            20              


<210> 6085
<211> 459
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<400> 6085
Met Ala Leu Xaa Leu Phe Asp Xaa Asp Glu Tyr Arg Pro Pro Val Trp 
1               5                   10                  15      


Lys Ser Tyr Leu Tyr Gln Leu Gln Gln Glu Ala Pro His Pro Arg Arg 
            20                  25                  30          


Ile Xaa Cys Xaa Cys Glu Val Glu Asn Arg Pro Lys Tyr Tyr Gly Arg 
        35                  40                  45              


Glu Phe His Gly Met Ile Ser Arg Glu Ala Ala Asp Gln Leu Leu Ile 
    50                  55                  60                  


Val Ala Glu Gly Ser Tyr Leu Ile Arg Glu Ser Gln Arg Gln Pro Gly 
65                  70                  75                  80  


Xaa Tyr Xaa Leu Ala Leu Arg Phe Gly Ser Gln Xaa Arg Asn Phe Arg 
                85                  90                  95      


Leu Tyr Tyr Asp Gly Lys His Phe Val Gly Glu Lys Arg Phe Glu Ser 
            100                 105                 110         


Ile His Asp Leu Val Xaa Asp Gly Leu Ile Xaa Leu Tyr Ile Glu Xaa 
        115                 120                 125             


Lys Ala Ala Glu Tyr Ile Ala Lys Met Xaa Ile Asn Pro Ile Tyr Glu 
    130                 135                 140                 


His Val Gly Tyr Xaa Xaa Leu Asn Arg Glu Pro Ala Tyr Lys Lys His 
145                 150                 155                 160 


Met Pro Val Leu Lys Glu Xaa His Asp Glu Arg Asp Ser Xaa Gly Gln 
                165                 170                 175     


Asp Gly Val Ser Glu Lys Arg Leu Xaa Ser Leu Val Arg Arg Ala Xaa 
            180                 185                 190         


Leu Lys Glu Asn Glu Gln Ile Pro Lys Tyr Glu Lys Ile His Asn Phe 
        195                 200                 205             


Lys Val His Xaa Phe Arg Gly Pro His Trp Cys Glu Tyr Cys Ala Asn 
    210                 215                 220                 


Phe Met Trp Gly Leu Ile Ala Gln Gly Val Lys Cys Ala Asp Cys Gly 
225                 230                 235                 240 


Leu Asn Val His Lys Gln Cys Ser Lys Met Val Pro Asn Asp Cys Lys 
                245                 250                 255     


Pro Asp Leu Lys His Val Lys Lys Val Tyr Ser Cys Asp Leu Xaa Xaa 
            260                 265                 270         


Leu Val Lys Ala His Xaa Xaa Lys Arg Pro Met Val Val Asp Met Cys 
        275                 280                 285             


Ile Arg Glu Ile Glu Ser Arg Gly Leu Asn Ser Glu Gly Leu Tyr Arg 
    290                 295                 300                 


Val Ser Gly Phe Ser Asp Leu Ile Glu Asp Val Lys Met Ala Phe Asp 
305                 310                 315                 320 


Arg Asp Gly Glu Lys Ala Asp Ile Ser Val Asn Met Tyr Glu Asp Ile 
                325                 330                 335     


Asn Ile Ile Xaa Gly Ala Leu Lys Leu Tyr Phe Arg Asp Leu Pro Ile 
            340                 345                 350         


Pro Leu Ile Xaa Tyr Asp Ala Tyr Pro Lys Phe Ile Glu Ser Ala Lys 
        355                 360                 365             


Ile Met Asp Pro Asp Glu Gln Leu Glu Xaa Leu His Glu Ala Leu Lys 
    370                 375                 380                 


Leu Leu Pro Pro Ala His Cys Glu Xaa Leu Arg Tyr Leu Met Ala His 
385                 390                 395                 400 


Leu Lys Arg Val Xaa Leu His Glu Lys Glu Asn Leu Met Asn Ala Glu 
                405                 410                 415     


Asn Leu Gly Ile Val Phe Gly Pro Xaa Leu Met Arg Ser Pro Glu Leu 
            420                 425                 430         


Asp Ala Met Ala Ala Leu Asn Asp Ile Arg Tyr Gln Arg Leu Val Val 
        435                 440                 445             


Glu Leu Leu Ile Lys Asn Glu Asp Ile Leu Phe 
    450                 455                 


<210> 6086
<211> 433
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<400> 6086
Met Ala Leu Xaa Leu Phe Asp Xaa Asp Glu Tyr Arg Pro Pro Val Trp 
1               5                   10                  15      


Lys Ser Tyr Leu Tyr Gln Leu Gln Gln Glu Ala Pro His Pro Arg Arg 
            20                  25                  30          


Ile Xaa Cys Xaa Cys Glu Val Glu Asn Arg Pro Lys Tyr Tyr Gly Arg 
        35                  40                  45              


Glu Phe His Gly Met Ile Ser Arg Glu Ala Ala Asp Gln Leu Leu Ile 
    50                  55                  60                  


Val Ala Glu Gly Ser Tyr Leu Ile Arg Glu Ser Gln Arg Gln Pro Gly 
65                  70                  75                  80  


Xaa Tyr Xaa Leu Ala Leu Arg Phe Gly Ser Gln Xaa Arg Asn Phe Arg 
                85                  90                  95      


Leu Tyr Tyr Asp Gly Lys His Phe Val Gly Glu Lys Arg Phe Glu Ser 
            100                 105                 110         


Ile His Asp Leu Val Xaa Asp Gly Leu Ile Xaa Leu Tyr Ile Glu Xaa 
        115                 120                 125             


Lys Ala Ala Glu Tyr Ile Ala Lys Met Xaa Ile Asn Pro Ile Tyr Glu 
    130                 135                 140                 


His Val Gly Tyr Xaa Xaa Leu Asn Arg Glu Pro Ala Tyr Lys Lys His 
145                 150                 155                 160 


Met Pro Val Leu Lys Glu Xaa His Asp Glu Arg Asp Ser Xaa Gly Gln 
                165                 170                 175     


Asp Gly Val Ser Glu Lys Arg Val His Xaa Phe Arg Gly Pro His Trp 
            180                 185                 190         


Cys Glu Tyr Cys Ala Asn Phe Met Trp Gly Leu Ile Ala Gln Gly Val 
        195                 200                 205             


Lys Cys Ala Asp Cys Gly Leu Asn Val His Lys Gln Cys Ser Lys Met 
    210                 215                 220                 


Val Pro Asn Asp Cys Lys Pro Asp Leu Lys His Val Lys Lys Val Tyr 
225                 230                 235                 240 


Ser Cys Asp Leu Xaa Xaa Leu Val Lys Ala His Xaa Xaa Lys Arg Pro 
                245                 250                 255     


Met Val Val Asp Met Cys Ile Arg Glu Ile Glu Ser Arg Gly Leu Asn 
            260                 265                 270         


Ser Glu Gly Leu Tyr Arg Val Ser Gly Phe Ser Asp Leu Ile Glu Asp 
        275                 280                 285             


Val Lys Met Ala Phe Asp Arg Asp Gly Glu Lys Ala Asp Ile Ser Val 
    290                 295                 300                 


Asn Met Tyr Glu Asp Ile Asn Ile Ile Xaa Gly Ala Leu Lys Leu Tyr 
305                 310                 315                 320 


Phe Arg Asp Leu Pro Ile Pro Leu Ile Xaa Tyr Asp Ala Tyr Pro Lys 
                325                 330                 335     


Phe Ile Glu Ser Ala Lys Ile Met Asp Pro Asp Glu Gln Leu Glu Xaa 
            340                 345                 350         


Leu His Glu Ala Leu Lys Leu Leu Pro Pro Ala His Cys Glu Xaa Leu 
        355                 360                 365             


Arg Tyr Leu Met Ala His Leu Lys Arg Val Xaa Leu His Glu Lys Glu 
    370                 375                 380                 


Asn Leu Met Asn Ala Glu Asn Leu Gly Ile Val Phe Gly Pro Xaa Leu 
385                 390                 395                 400 


Met Arg Ser Pro Glu Leu Asp Ala Met Ala Ala Leu Asn Asp Ile Arg 
                405                 410                 415     


Tyr Gln Arg Leu Val Val Glu Leu Leu Ile Lys Asn Glu Asp Ile Leu 
            420                 425                 430         


Phe 
    


<210> 6087
<211> 22
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<400> 6087
Met Ala Leu Xaa Leu Phe Asp Xaa Asp Glu Tyr Arg Pro Pro Val Trp 
1               5                   10                  15      


Lys Ser Tyr Tyr Ile Leu 
            20          


<210> 6088
<211> 185
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<400> 6088
Met Ala Xaa Met Gly Leu Leu Met Leu Leu Xaa Leu Ala Ala Ser Pro 
1               5                   10                  15      


His Phe Leu Ser Ile Cys Phe His His Val Cys Val His Xaa Phe Arg 
            20                  25                  30          


Gly Pro His Trp Cys Glu Tyr Cys Ala Asn Phe Met Trp Gly Leu Ile 
        35                  40                  45              


Ala Gln Gly Val Lys Cys Ala Asp Cys Gly Leu Asn Val His Lys Gln 
    50                  55                  60                  


Cys Ser Lys Met Val Pro Asn Asp Cys Lys Pro Asp Leu Lys His Val 
65                  70                  75                  80  


Lys Lys Val Tyr Ser Cys Asp Leu Xaa Xaa Leu Val Lys Ala His Xaa 
                85                  90                  95      


Xaa Lys Arg Pro Met Val Val Asp Met Cys Ile Arg Glu Ile Glu Ser 
            100                 105                 110         


Arg Gly Leu Asn Ser Glu Gly Leu Tyr Arg Val Ser Gly Phe Ser Asp 
        115                 120                 125             


Leu Ile Glu Asp Val Lys Met Ala Phe Asp Arg Asp Gly Glu Lys Ala 
    130                 135                 140                 


Asp Ile Ser Val Asn Met Tyr Glu Asp Ile Asn Ile Ile Xaa Gly Ala 
145                 150                 155                 160 


Leu Lys Leu Tyr Phe Arg Asp Leu Pro Ile Pro Leu Ile Xaa Tyr Asp 
                165                 170                 175     


Ala Tyr Pro Lys Phe Ile Glu Ser Ala 
            180                 185 


<210> 6089
<211> 275
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<400> 6089
Met Ala Xaa Met Gly Leu Leu Met Leu Leu Xaa Leu Ala Ala Ser Pro 
1               5                   10                  15      


His Phe Leu Ser Ile Cys Phe His His Val His Xaa Phe Arg Gly Pro 
            20                  25                  30          


His Trp Cys Glu Tyr Cys Ala Asn Phe Met Trp Gly Leu Ile Ala Gln 
        35                  40                  45              


Gly Val Lys Cys Ala Asp Cys Gly Leu Asn Val His Lys Gln Cys Ser 
    50                  55                  60                  


Lys Met Val Pro Asn Asp Cys Lys Pro Asp Leu Lys His Val Lys Lys 
65                  70                  75                  80  


Val Tyr Ser Cys Asp Leu Xaa Xaa Leu Val Lys Ala His Xaa Xaa Lys 
                85                  90                  95      


Arg Pro Met Val Val Asp Met Cys Ile Arg Glu Ile Glu Ser Arg Gly 
            100                 105                 110         


Leu Asn Ser Glu Gly Leu Tyr Arg Val Ser Gly Phe Ser Asp Leu Ile 
        115                 120                 125             


Glu Asp Val Lys Met Ala Phe Asp Arg Asp Gly Glu Lys Ala Asp Ile 
    130                 135                 140                 


Ser Val Asn Met Tyr Glu Asp Ile Asn Ile Ile Xaa Gly Ala Leu Lys 
145                 150                 155                 160 


Leu Tyr Phe Arg Asp Leu Pro Ile Pro Leu Ile Xaa Tyr Asp Ala Tyr 
                165                 170                 175     


Pro Lys Phe Ile Glu Ser Ala Lys Ile Met Asp Pro Asp Glu Gln Leu 
            180                 185                 190         


Glu Xaa Leu His Glu Ala Leu Lys Leu Leu Pro Pro Ala His Cys Glu 
        195                 200                 205             


Xaa Leu Arg Tyr Leu Met Ala His Leu Lys Arg Val Xaa Leu His Glu 
    210                 215                 220                 


Lys Glu Asn Leu Met Asn Ala Glu Asn Leu Gly Ile Val Phe Gly Pro 
225                 230                 235                 240 


Xaa Leu Met Arg Ser Pro Glu Leu Asp Ala Met Ala Ala Leu Asn Asp 
                245                 250                 255     


Ile Arg Tyr Gln Arg Leu Val Val Glu Leu Leu Ile Lys Asn Glu Asp 
            260                 265                 270         


Ile Leu Phe 
        275 


<210> 6090
<211> 334
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<400> 6090
Met Pro Ser Lys Glu Ser Trp Ser Gly Arg Lys Xaa Asn Arg Ala Ala 
1               5                   10                  15      


Val His Lys Ser Lys Gln Glu Gly Arg Gln Gln Asp Leu Leu Ile Ala 
            20                  25                  30          


Ala Leu Gly Met Lys Leu Gly Ser Pro Lys Ser Ser Val Xaa Ile Trp 
        35                  40                  45              


Gln Pro Leu Lys Leu Phe Ala Tyr Ser Gln Leu Xaa Ser Leu Val Arg 
    50                  55                  60                  


Arg Ala Xaa Leu Lys Glu Asn Glu Gln Ile Pro Lys Tyr Glu Lys Ile 
65                  70                  75                  80  


His Asn Phe Lys Val His Xaa Phe Arg Gly Pro His Trp Cys Glu Tyr 
                85                  90                  95      


Cys Ala Asn Phe Met Trp Gly Leu Ile Ala Gln Gly Val Lys Cys Ala 
            100                 105                 110         


Asp Cys Gly Leu Asn Val His Lys Gln Cys Ser Lys Met Val Pro Asn 
        115                 120                 125             


Asp Cys Lys Pro Asp Leu Lys His Val Lys Lys Val Tyr Ser Cys Asp 
    130                 135                 140                 


Leu Xaa Xaa Leu Val Lys Ala His Xaa Xaa Lys Arg Pro Met Val Val 
145                 150                 155                 160 


Asp Met Cys Ile Arg Glu Ile Glu Ser Arg Gly Leu Asn Ser Glu Gly 
                165                 170                 175     


Leu Tyr Arg Val Ser Gly Phe Ser Asp Leu Ile Glu Asp Val Lys Met 
            180                 185                 190         


Ala Phe Asp Arg Asp Gly Glu Lys Ala Asp Ile Ser Val Asn Met Tyr 
        195                 200                 205             


Glu Asp Ile Asn Ile Ile Xaa Gly Ala Leu Lys Leu Tyr Phe Arg Asp 
    210                 215                 220                 


Leu Pro Ile Pro Leu Ile Xaa Tyr Asp Ala Tyr Pro Lys Phe Ile Glu 
225                 230                 235                 240 


Ser Ala Lys Ile Met Asp Pro Asp Glu Gln Leu Glu Xaa Leu His Glu 
                245                 250                 255     


Ala Leu Lys Leu Leu Pro Pro Ala His Cys Glu Xaa Leu Arg Tyr Leu 
            260                 265                 270         


Met Ala His Leu Lys Arg Val Xaa Leu His Glu Lys Glu Asn Leu Met 
        275                 280                 285             


Asn Ala Glu Asn Leu Gly Ile Val Phe Gly Pro Xaa Leu Met Arg Ser 
    290                 295                 300                 


Pro Glu Leu Asp Ala Met Ala Ala Leu Asn Asp Ile Arg Tyr Gln Arg 
305                 310                 315                 320 


Leu Val Val Glu Leu Leu Ile Lys Asn Glu Asp Ile Leu Phe 
                325                 330                 


<210> 6091
<211> 165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(164)
<223> Selenocysteine

<400> 6091
Met Pro Ser Lys Glu Ser Trp Ser Gly Arg Lys Xaa Asn Arg Ala Ala 
1               5                   10                  15      


Val His Lys Ser Lys Gln Glu Gly Arg Gln Gln Asp Leu Leu Ile Ala 
            20                  25                  30          


Ala Leu Gly Met Lys Leu Gly Ser Pro Lys Ser Ser Val Xaa Ile Trp 
        35                  40                  45              


Gln Pro Leu Lys Leu Phe Ala Tyr Ser Gln Leu Xaa Ser Leu Val Arg 
    50                  55                  60                  


Arg Ala Xaa Leu Lys Glu Asn Glu Gln Ile Pro Lys Tyr Glu Lys Ile 
65                  70                  75                  80  


His Asn Phe Lys Val His Xaa Phe Arg Gly Pro His Trp Cys Glu Tyr 
                85                  90                  95      


Cys Ala Asn Phe Met Trp Gly Leu Ile Ala Gln Gly Val Lys Cys Ala 
            100                 105                 110         


Val Leu Glu Ala Arg Lys Ser Lys Ile Lys Leu Ala Ala Gly Ser Val 
        115                 120                 125             


Ser Asp Cys Gly Leu Asn Val His Lys Gln Cys Ser Lys Met Val Pro 
    130                 135                 140                 


Asn Asp Cys Lys Pro Asp Leu Lys His Val Lys Lys Val Tyr Ser Cys 
145                 150                 155                 160 


Asp Leu Xaa Xaa Leu 
                165 


<210> 6092
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<400> 6092
Met Arg Gly Gly Arg Asn Arg Asp Arg Leu Xaa Ser Leu Val Arg Arg 
1               5                   10                  15      


Ala Xaa Leu Lys Glu Asn Glu Gln Ile Pro Lys Tyr Glu Lys Ile His 
            20                  25                  30          


Asn Phe Lys Val His Xaa Phe Arg Gly Pro His Trp Cys Glu Tyr Cys 
        35                  40                  45              


Ala Asn Phe Met Trp Gly Leu Ile Ala Gln Gly Val Lys Cys Ala Asp 
    50                  55                  60                  


Cys Gly Leu Asn Val His Lys Gln Cys Ser Lys Met Val Pro Asn Asp 
65                  70                  75                  80  


Cys Lys Pro Asp Leu Lys His Val Lys Lys Val Tyr Ser Cys Asp Leu 
                85                  90                  95      


Xaa Xaa Leu Val Lys Ala His Xaa Xaa Lys Arg Pro Met Val Val Asp 
            100                 105                 110         


Met Cys Ile Arg Glu Ile Glu Ser Arg Gly Leu Asn Ser Glu Gly Leu 
        115                 120                 125             


Tyr Arg Val Ser Gly Phe Ser Asp Leu Ile Glu Asp Val Lys Met Ala 
    130                 135                 140                 


Phe Asp Arg Asp Gly Glu Lys Ala Asp Ile Ser Val Asn Met Tyr Glu 
145                 150                 155                 160 


Asp Ile Asn Ile Ile Xaa Gly Ala Leu Lys Leu Tyr Phe Arg Asp Leu 
                165                 170                 175     


Pro Ile Pro Leu Ile Xaa Tyr Asp Ala Tyr 
            180                 185     


<210> 6093
<211> 173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<400> 6093
Met Trp Gly Leu Ile Ala Gln Gly Val Lys Cys Ala Asp Cys Gly Leu 
1               5                   10                  15      


Asn Val His Lys Gln Cys Ser Lys Met Val Pro Asn Asp Cys Lys Pro 
            20                  25                  30          


Asp Leu Lys His Val Lys Lys Val Tyr Ser Cys Asp Leu Xaa Xaa Leu 
        35                  40                  45              


Val Lys Ala His Xaa Xaa Lys Arg Pro Met Val Val Asp Met Cys Ile 
    50                  55                  60                  


Arg Glu Ile Glu Ser Arg Gly Leu Asn Ser Glu Gly Leu Tyr Arg Val 
65                  70                  75                  80  


Ser Gly Phe Ser Asp Leu Ile Glu Asp Val Lys Met Ala Phe Asp Arg 
                85                  90                  95      


Asp Gly Glu Lys Ala Asp Ile Ser Val Asn Met Tyr Glu Asp Ile Asn 
            100                 105                 110         


Ile Ile Xaa Gly Ala Leu Lys Leu Tyr Phe Arg Asp Leu Pro Ile Pro 
        115                 120                 125             


Leu Ile Xaa Tyr Asp Ala Tyr Pro Lys Phe Ile Glu Ser Ala Lys Ile 
    130                 135                 140                 


Met Asp Pro Asp Glu Gln Leu Glu Xaa Leu His Glu Ala Leu Lys Leu 
145                 150                 155                 160 


Leu Pro Pro Ala His Cys Glu Xaa Leu Arg Tyr Leu Met 
                165                 170             


<210> 6094
<211> 194
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<400> 6094
Met Trp Gly Leu Ile Ala Gln Gly Val Lys Cys Ala Val Leu Glu Ala 
1               5                   10                  15      


Arg Lys Ser Lys Ile Lys Leu Ala Ala Gly Ser Val Ser Asp Cys Gly 
            20                  25                  30          


Leu Asn Val His Lys Gln Cys Ser Lys Met Val Pro Asn Asp Cys Lys 
        35                  40                  45              


Pro Asp Leu Lys His Val Lys Lys Val Tyr Ser Cys Asp Leu Xaa Xaa 
    50                  55                  60                  


Leu Val Lys Ala His Xaa Xaa Lys Arg Pro Met Val Val Asp Met Cys 
65                  70                  75                  80  


Ile Arg Glu Ile Glu Ser Arg Gly Leu Asn Ser Glu Gly Leu Tyr Arg 
                85                  90                  95      


Val Ser Gly Phe Ser Asp Leu Ile Glu Asp Val Lys Met Ala Phe Asp 
            100                 105                 110         


Arg Asp Gly Glu Lys Ala Asp Ile Ser Val Asn Met Tyr Glu Asp Ile 
        115                 120                 125             


Asn Ile Ile Xaa Gly Ala Leu Lys Leu Tyr Phe Arg Asp Leu Pro Ile 
    130                 135                 140                 


Pro Leu Ile Xaa Tyr Asp Ala Tyr Pro Lys Phe Ile Glu Ser Ala Lys 
145                 150                 155                 160 


Ile Met Asp Pro Asp Glu Gln Leu Glu Xaa Leu His Glu Ala Leu Lys 
                165                 170                 175     


Leu Leu Pro Pro Ala His Cys Glu Xaa Leu Arg Tyr Leu Met Ala His 
            180                 185                 190         


Leu Lys 
        


<210> 6095
<211> 124
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(102)
<223> Selenocysteine

<400> 6095
Met Ala Ala Ser Ser Asn Ser Ser Leu Ser Gly Ser Ser Val Ser Ser 
1               5                   10                  15      


Asp Ala Glu Glu Tyr Gln Pro Pro Ile Trp Lys Ser Tyr Leu Tyr Gln 
            20                  25                  30          


Leu Gln Gln Glu Ala Pro Arg Pro Lys Arg Ile Ile Cys Pro Arg Glu 
        35                  40                  45              


Val Glu Asn Arg Pro Lys Tyr Tyr Glu Xaa Leu Arg Tyr Leu Met Ile 
    50                  55                  60                  


His Leu Lys Lys Val Xaa Met Asn Glu Lys Asp Asn Phe Met Asn Ala 
65                  70                  75                  80  


Glu Asn Leu Gly Ile Val Phe Gly Pro Xaa Leu Met Arg Pro Pro Glu 
                85                  90                  95      


Asp Ser Xaa Leu Xaa Xaa Leu His Asp Met Arg Tyr Gln Lys Leu Ile 
            100                 105                 110         


Val Gln Ile Leu Ile Glu Asn Glu Asp Val Leu Phe 
        115                 120                 


<210> 6096
<211> 189
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(167)
<223> Selenocysteine

<400> 6096
Met Ala Ala Ser Ser Asn Ser Ser Leu Ser Gly Ser Ser Val Ser Ser 
1               5                   10                  15      


Asp Ala Glu Glu Tyr Gln Pro Pro Ile Trp Lys Ser Tyr Leu Tyr Gln 
            20                  25                  30          


Leu Gln Gln Glu Ala Pro Arg Pro Lys Arg Ile Ile Cys Pro Arg Glu 
        35                  40                  45              


Val Glu Asn Arg Pro Lys Tyr Tyr Gly Arg Glu Phe His Gly Ile Ile 
    50                  55                  60                  


Ser Arg Glu Gln Ala Asp Glu Leu Leu Gly Gly Val Glu Gly Ala Tyr 
65                  70                  75                  80  


Ile Leu Arg Glu Ser Gln Arg Gln Pro Gly Cys Tyr Xaa Leu Ala Leu 
                85                  90                  95      


Arg Glu Ile Ser Asn Ala Asp Glu Arg Leu Glu Ala Val His Glu Val 
            100                 105                 110         


Leu Met Leu Leu Pro Pro Ala His Tyr Glu Xaa Leu Arg Tyr Leu Met 
        115                 120                 125             


Ile His Leu Lys Lys Val Xaa Met Asn Glu Lys Asp Asn Phe Met Asn 
    130                 135                 140                 


Ala Glu Asn Leu Gly Ile Val Phe Gly Pro Xaa Leu Met Arg Pro Pro 
145                 150                 155                 160 


Glu Asp Ser Xaa Leu Xaa Xaa Leu His Asp Met Arg Tyr Gln Lys Leu 
                165                 170                 175     


Ile Val Gln Ile Leu Ile Glu Asn Glu Asp Val Leu Phe 
            180                 185                 


<210> 6097
<211> 468
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(446)
<223> Selenocysteine

<400> 6097
Met Ala Ala Ser Ser Asn Ser Ser Leu Ser Gly Ser Ser Val Ser Ser 
1               5                   10                  15      


Asp Ala Glu Glu Tyr Gln Pro Pro Ile Trp Lys Ser Tyr Leu Tyr Gln 
            20                  25                  30          


Leu Gln Gln Glu Ala Pro Arg Pro Lys Arg Ile Ile Cys Pro Arg Glu 
        35                  40                  45              


Val Glu Asn Arg Pro Lys Tyr Tyr Gly Arg Glu Phe His Gly Ile Ile 
    50                  55                  60                  


Ser Arg Glu Gln Ala Asp Glu Leu Leu Gly Gly Val Glu Gly Ala Tyr 
65                  70                  75                  80  


Ile Leu Arg Glu Ser Gln Arg Gln Pro Gly Cys Tyr Xaa Leu Ala Leu 
                85                  90                  95      


Arg Phe Gly Asn Gln Xaa Leu Asn Tyr Arg Leu Phe His Asp Gly Lys 
            100                 105                 110         


His Phe Val Gly Glu Lys Arg Phe Glu Ser Ile His Asp Leu Val Xaa 
        115                 120                 125             


Asp Gly Leu Ile Xaa Leu Tyr Ile Glu Xaa Lys Ala Ala Glu Tyr Ile 
    130                 135                 140                 


Ser Lys Met Xaa Xaa Asn Pro Ile Tyr Glu His Ile Gly Tyr Ala Xaa 
145                 150                 155                 160 


Leu Leu Arg Glu Lys Val Ser Arg Arg Leu Ser Arg Ser Lys Asn Glu 
                165                 170                 175     


Pro Arg Lys Xaa Asn Val Xaa His Glu Glu His Xaa Ala Val Glu Lys 
            180                 185                 190         


Ile Ser Ser Leu Val Arg Arg Ala Ala Leu Xaa His Asn Asp Asn His 
        195                 200                 205             


Phe Asn Tyr Glu Lys Xaa His Asn Phe Lys Val His Xaa Phe Arg Gly 
    210                 215                 220                 


Pro His Trp Cys Glu Tyr Cys Ala Asn Phe Met Trp Gly Leu Ile Ala 
225                 230                 235                 240 


Gln Gly Val Arg Cys Ser Asp Cys Gly Leu Asn Val His Lys Gln Cys 
                245                 250                 255     


Ser Lys His Val Pro Asn Asp Cys Gln Pro Asp Leu Lys Arg Ile Lys 
            260                 265                 270         


Lys Val Tyr Cys Cys Asp Leu Xaa Xaa Leu Val Lys Ala His Asn Xaa 
        275                 280                 285             


Gln Arg Pro Met Val Val Asp Ile Cys Ile Arg Glu Ile Glu Ala Arg 
    290                 295                 300                 


Gly Leu Lys Ser Glu Gly Leu Tyr Arg Val Ser Gly Phe Xaa Glu His 
305                 310                 315                 320 


Ile Glu Asp Val Lys Met Ala Phe Asp Arg Asp Gly Glu Lys Ala Asp 
                325                 330                 335     


Ile Ser Ala Asn Val Tyr Pro Asp Ile Asn Ile Ile Xaa Gly Ala Leu 
            340                 345                 350         


Lys Leu Tyr Phe Arg Asp Leu Pro Ile Pro Val Ile Xaa Tyr Asp Xaa 
        355                 360                 365             


Tyr Ser Lys Phe Ile Asp Ala Ala Lys Ile Ser Asn Ala Asp Glu Arg 
    370                 375                 380                 


Leu Glu Ala Val His Glu Val Leu Met Leu Leu Pro Pro Ala His Tyr 
385                 390                 395                 400 


Glu Xaa Leu Arg Tyr Leu Met Ile His Leu Lys Lys Val Xaa Met Asn 
                405                 410                 415     


Glu Lys Asp Asn Phe Met Asn Ala Glu Asn Leu Gly Ile Val Phe Gly 
            420                 425                 430         


Pro Xaa Leu Met Arg Pro Pro Glu Asp Ser Xaa Leu Xaa Xaa Leu His 
        435                 440                 445             


Asp Met Arg Tyr Gln Lys Leu Ile Val Gln Ile Leu Ile Glu Asn Glu 
    450                 455                 460                 


Asp Val Leu Phe 
465             


<210> 6098
<211> 216
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<400> 6098
Met Ala Ala Ser Ser Asn Ser Ser Leu Ser Gly Ser Ser Val Ser Ser 
1               5                   10                  15      


Asp Ala Glu Glu Tyr Gln Pro Pro Ile Trp Lys Ser Tyr Leu Tyr Gln 
            20                  25                  30          


Leu Gln Gln Glu Ala Pro Arg Pro Lys Arg Ile Ile Cys Pro Arg Glu 
        35                  40                  45              


Val Glu Asn Arg Pro Lys Tyr Tyr Gly Arg Glu Phe His Gly Ile Ile 
    50                  55                  60                  


Ser Arg Glu Gln Ala Asp Glu Leu Leu Gly Gly Val Glu Gly Ala Tyr 
65                  70                  75                  80  


Ile Leu Arg Glu Ser Gln Arg Gln Pro Gly Cys Tyr Xaa Leu Ala Leu 
                85                  90                  95      


Arg Phe Gly Asn Gln Xaa Leu Asn Tyr Arg Leu Phe His Asp Gly Lys 
            100                 105                 110         


His Phe Val Gly Glu Lys Arg Phe Glu Ser Ile His Asp Leu Val Xaa 
        115                 120                 125             


Asp Gly Leu Ile Xaa Leu Tyr Ile Glu Xaa Lys Ala Ala Glu Tyr Ile 
    130                 135                 140                 


Ser Lys Met Xaa Xaa Asn Pro Ile Tyr Glu His Ile Gly Tyr Ala Xaa 
145                 150                 155                 160 


Leu Leu Arg Glu Lys Val Ser Arg Arg Leu Ser Arg Ser Lys Asn Glu 
                165                 170                 175     


Pro Arg Lys Xaa Asn Val Xaa His Glu Glu His Xaa Ala Val Glu Lys 
            180                 185                 190         


Ile Ser Ser Leu Val Arg Arg Ala Ala Leu Xaa His Asn Asp Asn His 
        195                 200                 205             


Phe Asn Tyr Glu Arg Xaa Ala Pro 
    210                 215     


<210> 6099
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(160)
<223> Selenocysteine

<400> 6099
Met Ala Ala Ser Ser Asn Ser Ser Leu Ser Gly Ser Ser Val Ser Ser 
1               5                   10                  15      


Asp Ala Glu Glu Tyr Gln Pro Pro Ile Trp Lys Ser Tyr Leu Tyr Gln 
            20                  25                  30          


Leu Gln Gln Glu Ala Pro Arg Pro Lys Arg Ile Ile Cys Pro Arg Glu 
        35                  40                  45              


Val Glu Asn Arg Pro Lys Tyr Tyr Gly Arg Glu Phe His Gly Ile Ile 
    50                  55                  60                  


Ser Arg Glu Gln Ala Asp Glu Leu Leu Gly Gly Val Glu Gly Ala Tyr 
65                  70                  75                  80  


Ile Leu Arg Glu Ser Gln Arg Gln Pro Gly Cys Tyr Xaa Leu Ala Leu 
                85                  90                  95      


Arg Phe Gly Asn Gln Xaa Leu Asn Tyr Arg Leu Phe His Asp Gly Lys 
            100                 105                 110         


His Tyr Glu Xaa Leu Arg Tyr Leu Met Ile His Leu Lys Lys Val Xaa 
        115                 120                 125             


Met Asn Glu Lys Asp Asn Phe Met Asn Ala Glu Asn Leu Gly Ile Val 
    130                 135                 140                 


Phe Gly Pro Xaa Leu Met Arg Pro Pro Glu Asp Ser Xaa Leu Xaa Xaa 
145                 150                 155                 160 


Leu His Asp Met Arg Tyr Gln Lys Leu Ile Val Gln Ile Leu Ile Glu 
                165                 170                 175     


Asn Glu Asp Val Leu Phe 
            180         


<210> 6100
<211> 174
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 6100
Met Ala Ala Ser Ser Asn Ser Ser Leu Ser Gly Ser Ser Val Ser Ser 
1               5                   10                  15      


Val Tyr Ser Glu Pro Arg Ser Pro Arg Glu Leu Pro Lys Tyr Ala Glu 
            20                  25                  30          


Glu Tyr Gln Pro Pro Ile Trp Lys Ser Tyr Leu Tyr Gln Leu Gln Gln 
        35                  40                  45              


Glu Ala Pro Arg Pro Lys Arg Ile Ile Cys Pro Arg Glu Val Glu Asn 
    50                  55                  60                  


Arg Pro Lys Tyr Tyr Gly Arg Glu Phe His Gly Ile Ile Ser Arg Glu 
65                  70                  75                  80  


Gln Ala Asp Glu Leu Leu Gly Gly Val Glu Gly Ala Tyr Ile Leu Arg 
                85                  90                  95      


Glu Ser Gln Arg Gln Pro Gly Cys Tyr Xaa Leu Ala Leu Arg Phe Gly 
            100                 105                 110         


Asn Gln Xaa Leu Asn Tyr Arg Leu Phe His Asp Gly Lys His Phe Val 
        115                 120                 125             


Gly Glu Lys Arg Phe Glu Ser Ile His Asp Leu Val Xaa Asp Gly Leu 
    130                 135                 140                 


Ile Xaa Leu Tyr Ile Glu Xaa Lys Ala Ala Glu Tyr Ile Ser Lys Met 
145                 150                 155                 160 


Xaa Xaa Asn Pro Ile Tyr Glu His Ile Gly Tyr Ala Xaa Leu 
                165                 170                 


<210> 6101
<211> 260
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(238)
<223> Selenocysteine

<400> 6101
Met Phe Ser Glu Glu Leu Trp Leu Glu Asn Glu Lys Lys Cys Ala Val 
1               5                   10                  15      


Val Arg Lys Ser Lys Gln Gly Arg Lys Arg Gln Glu Leu Leu Ala Val 
            20                  25                  30          


Ala Phe Gly Val Lys Val Gly Val Lys Gly Gly Phe Leu Trp Pro Pro 
        35                  40                  45              


Leu Lys Leu Phe Ala Cys Ser Gln Ile Ser Ser Leu Val Arg Arg Ala 
    50                  55                  60                  


Ala Leu Xaa His Asn Asp Asn His Phe Asn Tyr Glu Lys Xaa His Asn 
65                  70                  75                  80  


Phe Lys Val His Xaa Phe Arg Gly Pro His Trp Cys Glu Tyr Cys Ala 
                85                  90                  95      


Asn Phe Met Trp Gly Leu Ile Ala Gln Gly Val Arg Cys Ser Asp Cys 
            100                 105                 110         


Gly Leu Asn Val His Lys Gln Cys Ser Lys His Val Pro Asn Asp Cys 
        115                 120                 125             


Gln Pro Asp Leu Lys Arg Ile Lys Lys Val Tyr Cys Cys Asp Leu Xaa 
    130                 135                 140                 


Xaa Leu Val Lys Ala His Asn Xaa Gln Arg Pro Met Val Val Asp Ile 
145                 150                 155                 160 


Cys Ile Arg Glu Ile Glu Ala Arg Glu Ile Ser Asn Ala Asp Glu Arg 
                165                 170                 175     


Leu Glu Ala Val His Glu Val Leu Met Leu Leu Pro Pro Ala His Tyr 
            180                 185                 190         


Glu Xaa Leu Arg Tyr Leu Met Ile His Leu Lys Lys Val Xaa Met Asn 
        195                 200                 205             


Glu Lys Asp Asn Phe Met Asn Ala Glu Asn Leu Gly Ile Val Phe Gly 
    210                 215                 220                 


Pro Xaa Leu Met Arg Pro Pro Glu Asp Ser Xaa Leu Xaa Xaa Leu His 
225                 230                 235                 240 


Asp Met Arg Tyr Gln Lys Leu Ile Val Gln Ile Leu Ile Glu Asn Glu 
                245                 250                 255     


Asp Val Leu Phe 
            260 


<210> 6102
<211> 332
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(310)
<223> Selenocysteine

<400> 6102
Met Phe Ser Glu Glu Leu Trp Leu Glu Asn Glu Lys Lys Cys Ala Val 
1               5                   10                  15      


Val Arg Lys Ser Lys Gln Gly Arg Lys Arg Gln Glu Leu Leu Ala Val 
            20                  25                  30          


Ala Phe Gly Val Lys Val Gly Val Lys Gly Gly Phe Leu Trp Pro Pro 
        35                  40                  45              


Leu Lys Leu Phe Ala Cys Ser Gln Ile Ser Ser Leu Val Arg Arg Ala 
    50                  55                  60                  


Ala Leu Xaa His Asn Asp Asn His Phe Asn Tyr Glu Lys Xaa His Asn 
65                  70                  75                  80  


Phe Lys Val His Xaa Phe Arg Gly Pro His Trp Cys Glu Tyr Cys Ala 
                85                  90                  95      


Asn Phe Met Trp Gly Leu Ile Ala Gln Gly Val Arg Cys Ser Asp Cys 
            100                 105                 110         


Gly Leu Asn Val His Lys Gln Cys Ser Lys His Val Pro Asn Asp Cys 
        115                 120                 125             


Gln Pro Asp Leu Lys Arg Ile Lys Lys Val Tyr Cys Cys Asp Leu Xaa 
    130                 135                 140                 


Xaa Leu Val Lys Ala His Asn Xaa Gln Arg Pro Met Val Val Asp Ile 
145                 150                 155                 160 


Cys Ile Arg Glu Ile Glu Ala Arg Gly Leu Lys Ser Glu Gly Leu Tyr 
                165                 170                 175     


Arg Val Ser Gly Phe Xaa Glu His Ile Glu Asp Val Lys Met Ala Phe 
            180                 185                 190         


Asp Arg Asp Gly Glu Lys Ala Asp Ile Ser Ala Asn Val Tyr Pro Asp 
        195                 200                 205             


Ile Asn Ile Ile Xaa Gly Ala Leu Lys Leu Tyr Phe Arg Asp Leu Pro 
    210                 215                 220                 


Ile Pro Val Ile Xaa Tyr Asp Xaa Tyr Ser Lys Phe Ile Asp Ala Ala 
225                 230                 235                 240 


Lys Ile Ser Asn Ala Asp Glu Arg Leu Glu Ala Val His Glu Val Leu 
                245                 250                 255     


Met Leu Leu Pro Pro Ala His Tyr Glu Xaa Leu Arg Tyr Leu Met Ile 
            260                 265                 270         


His Leu Lys Lys Val Xaa Met Asn Glu Lys Asp Asn Phe Met Asn Ala 
        275                 280                 285             


Glu Asn Leu Gly Ile Val Phe Gly Pro Xaa Leu Met Arg Pro Pro Glu 
    290                 295                 300                 


Asp Ser Xaa Leu Xaa Xaa Leu His Asp Met Arg Tyr Gln Lys Leu Ile 
305                 310                 315                 320 


Val Gln Ile Leu Ile Glu Asn Glu Asp Val Leu Phe 
                325                 330         


<210> 6103
<211> 197
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<400> 6103
Met Phe Ser Glu Glu Leu Trp Leu Glu Asn Glu Lys Lys Cys Ala Val 
1               5                   10                  15      


Val Arg Lys Ser Lys Gln Gly Arg Lys Arg Gln Glu Leu Leu Ala Val 
            20                  25                  30          


Ala Phe Gly Val Lys Val Gly Val Lys Gly Gly Phe Leu Trp Pro Pro 
        35                  40                  45              


Leu Lys Leu Phe Ala Cys Ser Gln Ile Ser Ser Leu Val Arg Arg Ala 
    50                  55                  60                  


Ala Leu Xaa His Asn Asp Asn His Phe Asn Tyr Glu Lys Xaa His Asn 
65                  70                  75                  80  


Phe Lys Val His Xaa Phe Arg Gly Pro His Trp Cys Glu Tyr Cys Ala 
                85                  90                  95      


Asn Phe Met Trp Gly Leu Ile Ala Gln Gly Val Arg Cys Ser Asp Cys 
            100                 105                 110         


Gly Leu Asn Val His Lys Gln Cys Ser Lys His Val Pro Asn Asp Cys 
        115                 120                 125             


Gln Pro Asp Leu Lys Arg Ile Lys Lys Val Tyr Cys Cys Asp Leu Xaa 
    130                 135                 140                 


Xaa Leu Val Lys Ala His Asn Xaa Gln Arg Pro Met Val Val Asp Ile 
145                 150                 155                 160 


Cys Ile Arg Glu Ile Glu Ala Arg Gly Leu Lys Ser Glu Gly Leu Tyr 
                165                 170                 175     


Arg Val Ser Gly Phe Xaa Glu His Ile Glu Asp Val Lys Met Ala Phe 
            180                 185                 190         


Asp Arg Gly Leu Leu 
        195         


<210> 6104
<211> 274
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(252)
<223> Selenocysteine

<400> 6104
Met Phe Ser Glu Glu Leu Trp Leu Glu Asn Glu Lys Lys Cys Ala Val 
1               5                   10                  15      


Val Arg Lys Ser Lys Gln Gly Arg Lys Arg Gln Glu Leu Leu Ala Val 
            20                  25                  30          


Ala Phe Gly Val Lys Val Gly Val Lys Gly Gly Phe Leu Trp Pro Pro 
        35                  40                  45              


Leu Lys Leu Phe Ala Cys Ser Gln Ile Ser Ser Leu Val Arg Arg Ala 
    50                  55                  60                  


Ala Leu Xaa His Asn Asp Asn His Phe Asn Tyr Glu Lys Xaa His Asn 
65                  70                  75                  80  


Phe Lys Val His Xaa Phe Arg Gly Pro His Trp Cys Glu Tyr Cys Ala 
                85                  90                  95      


Asn Phe Met Trp Gly Leu Ile Ala Gln Gly Val Arg Cys Ser Gly Leu 
            100                 105                 110         


Lys Ser Glu Gly Leu Tyr Arg Val Ser Gly Phe Xaa Glu His Ile Glu 
        115                 120                 125             


Asp Val Lys Met Ala Phe Asp Arg Asp Gly Glu Lys Ala Asp Ile Ser 
    130                 135                 140                 


Ala Asn Val Tyr Pro Asp Ile Asn Ile Ile Xaa Gly Ala Leu Lys Leu 
145                 150                 155                 160 


Tyr Phe Arg Asp Leu Pro Ile Pro Val Ile Xaa Tyr Asp Xaa Tyr Ser 
                165                 170                 175     


Lys Phe Ile Asp Ala Ala Lys Ile Ser Asn Ala Asp Glu Arg Leu Glu 
            180                 185                 190         


Ala Val His Glu Val Leu Met Leu Leu Pro Pro Ala His Tyr Glu Xaa 
        195                 200                 205             


Leu Arg Tyr Leu Met Ile His Leu Lys Lys Val Xaa Met Asn Glu Lys 
    210                 215                 220                 


Asp Asn Phe Met Asn Ala Glu Asn Leu Gly Ile Val Phe Gly Pro Xaa 
225                 230                 235                 240 


Leu Met Arg Pro Pro Glu Asp Ser Xaa Leu Xaa Xaa Leu His Asp Met 
                245                 250                 255     


Arg Tyr Gln Lys Leu Ile Val Gln Ile Leu Ile Glu Asn Glu Asp Val 
            260                 265                 270         


Leu Phe 
        


<210> 6105
<211> 228
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(206)
<223> Selenocysteine

<400> 6105
Met Phe Ser Glu Glu Leu Trp Leu Glu Asn Glu Lys Lys Cys Ala Val 
1               5                   10                  15      


Val Arg Lys Ser Lys Gln Gly Arg Lys Arg Gln Glu Leu Leu Ala Val 
            20                  25                  30          


Ala Phe Gly Val Lys Val Gly Val Lys Gly Gly Phe Leu Trp Pro Pro 
        35                  40                  45              


Leu Lys Leu Phe Ala Cys Ser Gln Ile Ser Ser Leu Val Arg Arg Ala 
    50                  55                  60                  


Ala Leu Xaa His Asn Asp Asn His Phe Asn Tyr Glu Lys Xaa His Asn 
65                  70                  75                  80  


Phe Lys Val His Xaa Phe Arg Gly Pro His Trp Cys Glu Tyr Cys Ala 
                85                  90                  95      


Asn Phe Met Trp Gly Leu Ile Ala Gln Gly Val Arg Cys Ser Gly Leu 
            100                 105                 110         


Lys Ser Glu Gly Leu Tyr Arg Val Ser Gly Phe Xaa Glu His Ile Glu 
        115                 120                 125             


Asp Val Lys Met Ala Phe Asp Arg Glu Ile Ser Asn Ala Asp Glu Arg 
    130                 135                 140                 


Leu Glu Ala Val His Glu Val Leu Met Leu Leu Pro Pro Ala His Tyr 
145                 150                 155                 160 


Glu Xaa Leu Arg Tyr Leu Met Ile His Leu Lys Lys Val Xaa Met Asn 
                165                 170                 175     


Glu Lys Asp Asn Phe Met Asn Ala Glu Asn Leu Gly Ile Val Phe Gly 
            180                 185                 190         


Pro Xaa Leu Met Arg Pro Pro Glu Asp Ser Xaa Leu Xaa Xaa Leu His 
        195                 200                 205             


Asp Met Arg Tyr Gln Lys Leu Ile Val Gln Ile Leu Ile Glu Asn Glu 
    210                 215                 220                 


Asp Val Leu Phe 
225             


<210> 6106
<211> 37
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<400> 6106
Met Xaa Gln Xaa His Arg Ala Lys Ser Ala Ser Ser Cys Pro Asn Leu 
1               5                   10                  15      


Leu Val Pro Glu Xaa Trp Pro His Gln Val Ser Ala Ser His Ala Gly 
            20                  25                  30          


Arg Ser Lys Gln Pro 
        35          


<210> 6107
<211> 187
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<400> 6107
Met Xaa Gln Xaa His Arg Ala Lys Ser Ala Ser Ser Cys Pro Asn Leu 
1               5                   10                  15      


Leu Val Pro Glu Xaa Trp Pro His Gln Val Ser Ala Ser His Ala Gly 
            20                  25                  30          


Arg Ser Lys Gln Pro Gln Gly Gly Ile Leu Lys Ile Asn Glu Glu His 
        35                  40                  45              


Arg Arg Gly Ala Ile Gln Asp Leu Leu Ala Ser Pro Gly Phe Xaa Phe 
    50                  55                  60                  


Gly Lys Arg Val Val Phe Asp Ser His Cys Leu Lys Arg Gln His Xaa 
65                  70                  75                  80  


Phe Ala Asp Gly Leu His Ser Ser Cys Xaa Ser Asn Ala Glu Glu Tyr 
                85                  90                  95      


Gln Pro Pro Ile Trp Lys Ser Tyr Leu Tyr Gln Leu Gln Gln Glu Ala 
            100                 105                 110         


Pro Arg Pro Lys Arg Ile Ile Cys Pro Arg Glu Val Glu Asn Arg Pro 
        115                 120                 125             


Lys Tyr Tyr Gly Arg Glu Phe His Gly Ile Ile Ser Arg Glu Gln Ala 
    130                 135                 140                 


Asp Glu Leu Leu Gly Gly Val Glu Gly Ala Tyr Ile Leu Arg Glu Ser 
145                 150                 155                 160 


Gln Arg Gln Pro Gly Cys Tyr Xaa Leu Ala Leu Arg Phe Gly Asn Gln 
                165                 170                 175     


Xaa Leu Asn Tyr Arg Leu Phe His Asp Gly Lys 
            180                 185         


<210> 6108
<211> 180
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<400> 6108
Asn Pro Ile Tyr Glu His Ile Gly Tyr Ala Xaa Leu Leu Arg Glu Lys 
1               5                   10                  15      


Val Ser Arg Arg Leu Ser Arg Ser Lys Asn Glu Pro Arg Lys Xaa Asn 
            20                  25                  30          


Val Xaa His Glu Glu His Xaa Ala Val Glu Lys Val His Xaa Phe Arg 
        35                  40                  45              


Gly Pro His Trp Cys Glu Tyr Cys Ala Asn Phe Met Trp Gly Leu Ile 
    50                  55                  60                  


Ala Gln Gly Val Arg Cys Ser Asp Cys Gly Leu Asn Val His Lys Gln 
65                  70                  75                  80  


Cys Ser Lys His Val Pro Asn Asp Cys Gln Pro Asp Leu Lys Arg Ile 
                85                  90                  95      


Lys Lys Val Tyr Cys Cys Asp Leu Xaa Xaa Leu Val Lys Ala His Asn 
            100                 105                 110         


Xaa Gln Arg Pro Met Val Val Asp Ile Cys Ile Arg Glu Ile Glu Ala 
        115                 120                 125             


Arg Gly Leu Lys Ser Glu Gly Leu Tyr Arg Val Ser Gly Phe Xaa Glu 
    130                 135                 140                 


His Ile Glu Asp Val Lys Met Ala Phe Asp Arg Asp Gly Glu Lys Ala 
145                 150                 155                 160 


Asp Ile Ser Ala Asn Val Tyr Pro Asp Ile Asn Ile Ile Xaa Gly Ala 
                165                 170                 175     


Leu Lys Leu Tyr 
            180 


<210> 6109
<211> 91
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 6109
Xaa Asp Val Lys Met Ala Phe Asp Arg Asp Gly Glu Lys Ala Asp Ile 
1               5                   10                  15      


Ser Ala Asn Val Tyr Pro Asp Ile Asn Ile Ile Xaa Gly Ala Leu Lys 
            20                  25                  30          


Leu Tyr Phe Arg Asp Leu Pro Ile Pro Val Ile Xaa Tyr Asp Xaa Tyr 
        35                  40                  45              


Ser Lys Phe Ile Asp Ala Ala Lys Ile Ser Asn Ala Asp Glu Arg Leu 
    50                  55                  60                  


Glu Ala Val His Glu Val Leu Met Leu Leu Pro Pro Ala His Tyr Glu 
65                  70                  75                  80  


Xaa Leu Arg Tyr Leu Met Ile His Leu Lys Lys 
                85                  90      


<210> 6110
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<400> 6110
Xaa Arg Ala Lys Ser Ala Ser Ser Cys Pro Asn Leu Leu Val Pro Glu 
1               5                   10                  15      


Xaa Trp Pro His Gln Val Ser Ala Ser His Ala Gly Arg Ser Lys Gln 
            20                  25                  30          


Pro Gln Gly Gly Ile Leu Lys Ile Asn Glu Glu His Arg Arg Gly Ala 
        35                  40                  45              


Ile Gln Met Leu Lys Asn Xaa Ser Leu Leu Tyr Gly Asn His Xaa Tyr 
    50                  55                  60                  


Ile Ser Tyr Ser Lys Arg His Leu Val Pro Arg Glu Ser Phe Val Leu 
65                  70                  75                  80  


Gly Arg Trp Lys Xaa Asp Gln Asn Ile Met Glu Glu Ser Phe Met Gly 
                85                  90                  95      


Ser Ser Leu Gly Ser Arg Arg Met Ser Phe Leu Glu Ala Trp Arg Val 
            100                 105                 110         


Pro Xaa Ser Leu Glu Lys Ala Ser Gly Asn Gln Asp Ala Xaa Arg Trp 
        115                 120                 125             


Leu Ser Gly Leu Glu Xaa Arg Pro 
    130                 135     


<210> 6111
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<400> 6111
Met Gly Ser Arg Ala Ser Xaa Leu Leu Arg Asp Glu Glu Leu Glu Glu 
1               5                   10                  15      


Ile Lys Lys Glu Xaa Gly Phe Ser His Ser Gln Ile Xaa Arg Leu Tyr 
            20                  25                  30          


Ser Arg Phe Xaa Ser Leu Asp Lys Gly Glu Asn Gly Xaa Leu Ser Arg 
        35                  40                  45              


Glu Asp Phe Gln Arg Ile Pro Glu Leu Ala Ile Asn Pro Leu Gly Asp 
    50                  55                  60                  


Arg Ile Ile Asn Ala Phe Phe Pro Glu Gly Glu Asp Gln Val Asn Phe 
65                  70                  75                  80  


Arg Gly Phe Met Arg Xaa Leu Ala His Phe Arg Pro Ile Glu Asp Asn 
                85                  90                  95      


Glu Lys Ser Lys Asp Val Asn Gly Pro Glu Pro Leu Asn Ser Arg Ser 
            100                 105                 110         


Asn Lys Leu His Cys Ala Xaa His Asp Gly Arg Ser Lys Tyr Leu Arg 
        115                 120                 125             


<210> 6112
<211> 154
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 6112
Met Gly Ser Arg Ala Ser Xaa Leu Leu Arg Asp Glu Glu Leu Glu Glu 
1               5                   10                  15      


Ile Lys Lys Glu Xaa Gly Phe Ser His Ser Gln Ile Xaa Arg Leu Tyr 
            20                  25                  30          


Ser Arg Phe Xaa Ser Leu Asp Lys Gly Glu Asn Gly Xaa Leu Ser Arg 
        35                  40                  45              


Glu Asp Phe Gln Arg Ile Pro Glu Leu Ala Ile Asn Pro Leu Gly Asp 
    50                  55                  60                  


Arg Ile Ile Asn Ala Phe Phe Pro Glu Gly Glu Asp Gln Val Asn Phe 
65                  70                  75                  80  


Arg Gly Phe Met Arg Xaa Leu Ala His Phe Arg Pro Ile Glu Asp Asn 
                85                  90                  95      


Glu Lys Ser Lys Asp Val Asn Gly Pro Glu Pro Leu Asn Ser Arg Ser 
            100                 105                 110         


Asn Lys Leu His Phe Ala Phe Arg Leu Tyr Asp Leu Asp Lys Asp Glu 
        115                 120                 125             


Lys Ile Ser Arg Asp Glu Leu Leu Gln Val Leu Glu Lys Val Asp Val 
    130                 135                 140                 


Glu Gln Lys Met Ser Ile Arg Phe Leu His 
145                 150                 


<210> 6113
<211> 195
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<400> 6113
Met Gly Ser Arg Ala Ser Xaa Leu Leu Arg Asp Glu Glu Leu Glu Glu 
1               5                   10                  15      


Ile Lys Lys Glu Xaa Gly Phe Ser His Ser Gln Ile Xaa Arg Leu Tyr 
            20                  25                  30          


Ser Arg Phe Xaa Ser Leu Asp Lys Gly Glu Asn Gly Xaa Leu Ser Arg 
        35                  40                  45              


Glu Asp Phe Gln Arg Ile Pro Glu Leu Ala Ile Asn Pro Leu Gly Asp 
    50                  55                  60                  


Arg Ile Ile Asn Ala Phe Phe Pro Glu Gly Glu Asp Gln Val Asn Phe 
65                  70                  75                  80  


Arg Gly Phe Met Arg Xaa Leu Ala His Phe Arg Pro Ile Glu Asp Asn 
                85                  90                  95      


Glu Lys Ser Lys Asp Val Asn Gly Pro Glu Pro Leu Asn Ser Arg Ser 
            100                 105                 110         


Asn Lys Leu His Phe Ala Phe Arg Leu Tyr Asp Leu Asp Lys Asp Glu 
        115                 120                 125             


Lys Ile Ser Arg Asp Glu Leu Leu Gln Val Leu Arg Met Met Val Gly 
    130                 135                 140                 


Val Asn Ile Ser Asp Glu Gln Leu Gly Ser Ile Ala Asp Arg Xaa Ile 
145                 150                 155                 160 


Gln Glu Ala Asp Gln Asp Gly Asp Ser Ala Ile Ser Phe Xaa Glu Phe 
                165                 170                 175     


Val Lys Val Leu Glu Lys Val Asp Val Glu Gln Lys Met Ser Ile Arg 
            180                 185                 190         


Phe Leu His 
        195 


<210> 6114
<211> 123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 6114
Met Gly Ser Arg Ala Ser Xaa Leu Leu Arg Asp Glu Glu Leu Glu Glu 
1               5                   10                  15      


Ile Lys Lys Glu Xaa Gly Phe Ser His Ser Gln Ile Xaa Arg Leu Tyr 
            20                  25                  30          


Ser Arg Phe Xaa Ser Leu Asp Lys Gly Glu Asn Gly Xaa Leu Ser Arg 
        35                  40                  45              


Glu Asp Phe Gln Arg Ile Pro Glu Leu Ala Ile Asn Pro Leu Gly Asp 
    50                  55                  60                  


Arg Ile Ile Asn Ala Phe Phe Pro Glu Gly Glu Asp Gln Val Asn Phe 
65                  70                  75                  80  


Arg Gly Phe Met Arg Xaa Leu Ala His Phe Arg Pro Ile Glu Asp Asn 
                85                  90                  95      


Glu Lys Ser Lys Asp Val Asn Gly Pro Glu Pro Leu Asn Ser Arg Ser 
            100                 105                 110         


Asn Lys Leu His Leu Glu Glu Glu Arg Tyr Ile 
        115                 120             


<210> 6115
<211> 53
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 6115
Met Gly Ser Arg Ala Ser Xaa Leu Leu Arg Asp Glu Glu Leu Glu Glu 
1               5                   10                  15      


Ile Lys Lys Glu Xaa Gly Ser Gly Lys Ile Ser Arg Gly Phe Gln Asn 
            20                  25                  30          


Leu Pro Ser Xaa His Trp Gly Xaa Gly Ser Ser Met Pro Ser Phe Gln 
        35                  40                  45              


Arg Glu Arg Xaa Arg 
    50              


<210> 6116
<211> 91
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<400> 6116
Xaa Arg Glu Asp Phe Gln Arg Ile Pro Glu Leu Ala Ile Asn Pro Leu 
1               5                   10                  15      


Gly Asp Arg Ile Ile Asn Ala Phe Phe Pro Glu Gly Glu Asp Gln Val 
            20                  25                  30          


Asn Phe Arg Gly Phe Met Arg Xaa Leu Ala His Phe Arg Pro Ile Glu 
        35                  40                  45              


Asp Asn Glu Lys Ser Lys Asp Val Asn Gly Pro Glu Pro Leu Asn Ser 
    50                  55                  60                  


Arg Ser Asn Lys Leu His Phe Ala Phe Arg Leu Tyr Asp Leu Asp Lys 
65                  70                  75                  80  


Asp Glu Lys Ile Ser Arg Asp Glu Leu Leu Gln 
                85                  90      


<210> 6117
<211> 196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<400> 6117
Met Gly Ser Arg Ser Ser His Ala Ala Val Ile Pro Asp Gly Asp Ser 
1               5                   10                  15      


Ile Arg Arg Glu Xaa Gly Phe Ser Gln Ala Ser Leu Leu Arg Leu His 
            20                  25                  30          


His Arg Phe Arg Ala Leu Asp Arg Asn Lys Lys Gly Tyr Leu Ser Arg 
        35                  40                  45              


Met Asp Leu Gln Gln Ile Gly Ala Leu Ala Val Asn Pro Leu Gly Asp 
    50                  55                  60                  


Arg Ile Ile Glu Ser Phe Phe Pro Asp Gly Ser Gln Arg Val Asp Phe 
65                  70                  75                  80  


Pro Gly Phe Val Arg Val Leu Ala His Phe Arg Pro Val Glu Asp Glu 
                85                  90                  95      


Asp Xaa Glu Xaa Gln Asp Pro Lys Lys Pro Glu Pro Leu Asn Ser Arg 
            100                 105                 110         


Arg Asn Lys Leu His Tyr Ala Phe Gln Leu Tyr Asp Leu Asp Arg Asp 
        115                 120                 125             


Gly Lys Ile Ser Arg His Glu Met Leu Gln Val Leu Arg Leu Met Val 
    130                 135                 140                 


Gly Val Gln Val Xaa Glu Glu Gln Leu Glu Asn Ile Ala Asp Arg Xaa 
145                 150                 155                 160 


Val Gln Glu Ala Asp Glu Asp Gly Asp Gly Ala Val Ser Phe Val Glu 
                165                 170                 175     


Phe Xaa Lys Ser Leu Glu Lys Met Asp Val Glu Gln Lys Met Ser Ile 
            180                 185                 190         


Arg Ile Leu Lys 
        195     


<210> 6118
<211> 80
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 6118
Phe Val Ala Phe Leu Arg Ser Ala Arg Pro Phe Leu Pro Cys Ala Pro 
1               5                   10                  15      


Ser Pro Arg Pro Pro His Cys Pro Pro Ala Val Ser Leu Ala Leu Pro 
            20                  25                  30          


Phe Gly Lys Pro Glu Leu Phe Val Gln Cys Leu Ala Xaa Tyr Ser Tyr 
        35                  40                  45              


Arg His Gly Ser Gly Lys Glu Lys Lys Val Leu Xaa Tyr Ser Asp Leu 
    50                  55                  60                  


Ala Asn Xaa Ala Gln Gln Ser Glu Xaa Phe Gln Phe Leu Ala Gly Xaa 
65                  70                  75                  80  


<210> 6119
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 6119
Met Ala Asp Val Val Val Gly Lys Asp Lys Gly Gly Glu Gln Arg Leu 
1               5                   10                  15      


Ile Ser Leu Pro Leu Ser Arg Ile Arg Val Ile Met Lys Ser Ser Pro 
            20                  25                  30          


Glu Val Ser Ser Ile Asn Gln Glu Ala Leu Val Leu Xaa Ala Lys Ala 
        35                  40                  45              


Xaa Glu Leu Phe Val Gln Cys Leu Ala Xaa Tyr Ser Tyr Arg His Gly 
    50                  55                  60                  


Ser Gly Lys Glu Lys Lys Val Leu Xaa Tyr Ser Asp Leu Ala Asn Xaa 
65                  70                  75                  80  


Ala Gln Gln Ser Glu Xaa Phe Gln Phe Leu Ala Asp Ile Leu Pro Lys 
                85                  90                  95      


Lys Ile Leu Ala Ser Lys Tyr Leu Lys Met Leu Lys Glu Glu Lys Arg 
            100                 105                 110         


Glu Glu Asp Glu Glu Asn Asp Asn Asp Asn Glu Ser Asp His Asp Glu 
        115                 120                 125             


Ala Asp Ser 
    130     


<210> 6120
<211> 56
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<400> 6120
Met Ala Asp Val Val Val Gly Lys Asp Lys Gly Gly Glu Gln Arg Leu 
1               5                   10                  15      


Ile Ser Leu Pro Leu Ser Arg Ile Arg Val Ile Met Lys Ser Ser Pro 
            20                  25                  30          


Glu Val Ser Ser Ile Asn Gln Glu Ala Leu Val Leu Xaa Ala Lys Ala 
        35                  40                  45              


Xaa Ile Tyr Tyr Gln Arg Arg Phe 
    50                  55      


<210> 6121
<211> 97
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 6121
Xaa Cys Pro Pro Ala Val Ser Leu Ala Leu Pro Phe Gly Lys Pro Glu 
1               5                   10                  15      


Leu Phe Val Gln Cys Leu Ala Xaa Tyr Ser Tyr Arg His Gly Ser Gly 
            20                  25                  30          


Lys Glu Lys Lys Val Leu Xaa Tyr Ser Asp Leu Ala Asn Xaa Ala Gln 
        35                  40                  45              


Gln Ser Glu Xaa Phe Gln Phe Leu Ala Asp Ile Leu Pro Lys Lys Ile 
    50                  55                  60                  


Leu Ala Ser Lys Tyr Leu Lys Met Leu Lys Glu Glu Lys Arg Glu Glu 
65                  70                  75                  80  


Asp Glu Glu Asn Asp Asn Asp Asn Glu Ser Asp His Asp Glu Ala Asp 
                85                  90                  95      


Ser 
    


<210> 6122
<211> 86
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<400> 6122
Met Pro Ser Leu Pro Ala Pro Pro Ala Pro Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ser Arg Pro Ala Arg Gly Ala Gly Pro Glu Pro Pro 
            20                  25                  30          


Val Leu Pro Ile Arg Ser Glu Lys Glu Pro Leu Pro Val Arg Gly Ala 
        35                  40                  45              


Ala Gly Cys Xaa Phe Gly Gly Lys Val Tyr Ala Leu Asp Glu Xaa Trp 
    50                  55                  60                  


His Pro Asp Leu Gly Glu Pro Phe Gly Val Met Arg Cys Val Leu Cys 
65                  70                  75                  80  


Ala Cys Glu Ala Gly Pro 
                85      


<210> 6123
<211> 350
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<400> 6123
Met Pro Ser Leu Pro Ala Pro Pro Ala Pro Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ser Arg Pro Ala Arg Gly Ala Gly Pro Glu Pro Pro 
            20                  25                  30          


Val Leu Pro Ile Arg Ser Glu Lys Glu Pro Leu Pro Val Arg Gly Ala 
        35                  40                  45              


Ala Gly Cys Xaa Phe Gly Gly Lys Val Tyr Ala Leu Asp Glu Xaa Trp 
    50                  55                  60                  


His Pro Asp Leu Gly Glu Pro Phe Gly Val Met Arg Cys Val Leu Cys 
65                  70                  75                  80  


Ala Cys Glu Ala Pro Gln Trp Gly Arg Arg Xaa Arg Gly Pro Gly Arg 
                85                  90                  95      


Val Ser Cys Lys Asn Ile Lys Pro Glu Cys Pro Xaa Pro Ala Cys Gly 
            100                 105                 110         


Gln Pro Arg Gln Leu Pro Gly His Cys Cys Gln Xaa Cys Pro Gln Glu 
        115                 120                 125             


Arg Ser Ser Ser Glu Arg Gln Pro Ser Gly Leu Ser Phe Glu Tyr Pro 
    130                 135                 140                 


Arg Asp Pro Glu His Arg Ser Tyr Ser Asp Arg Gly Glu Pro Gly Ala 
145                 150                 155                 160 


Glu Glu Arg Ala Arg Gly Asp Gly His Xaa Asp Phe Val Ala Leu Leu 
                165                 170                 175     


Xaa Gly Pro Arg Ser Gln Ala Val Ala Arg Ala Arg Val Ser Leu Leu 
            180                 185                 190         


Arg Ser Ser Leu Arg Phe Ser Ile Ser Tyr Arg Arg Leu Asp Arg Pro 
        195                 200                 205             


Xaa Arg Ile Arg Phe Ser Asp Ser Asn Gly Ser Val Leu Phe Glu His 
    210                 215                 220                 


Pro Ala Ala Pro Xaa Gln Asp Gly Leu Val Cys Gly Val Trp Arg Ala 
225                 230                 235                 240 


Val Pro Arg Leu Ser Leu Arg Leu Leu Arg Ala Glu Gln Leu His Val 
                245                 250                 255     


Ala Leu Val Xaa Leu Xaa His Pro Ser Gly Glu Val Trp Gly Pro Leu 
            260                 265                 270         


Ile Arg His Arg Ala Leu Ala Ala Glu Xaa Phe Ser Ala Ile Leu Xaa 
        275                 280                 285             


Leu Glu Gly Pro Pro Gln Gln Gly Val Gly Gly Ile Xaa Leu Leu Xaa 
    290                 295                 300                 


Leu Ser Asp Xaa Glu Asp Ser Leu His Phe Leu Leu Leu Phe Arg Gly 
305                 310                 315                 320 


Leu Leu Glu Pro Arg Ser Gly Asp Ser Xaa Pro Gly Ala Ala Xaa Ala 
                325                 330                 335     


Arg Xaa Ser Gly Gln Cys Leu Ser Pro Gly Xaa Arg Leu Cys 
            340                 345                 350 


<210> 6124
<211> 915
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<400> 6124
Met Pro Ser Leu Pro Ala Pro Pro Ala Pro Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ser Arg Pro Ala Arg Gly Ala Gly Pro Glu Pro Pro 
            20                  25                  30          


Val Leu Pro Ile Arg Ser Glu Lys Glu Pro Leu Pro Val Arg Gly Ala 
        35                  40                  45              


Ala Gly Cys Xaa Phe Gly Gly Lys Val Tyr Ala Leu Asp Glu Xaa Trp 
    50                  55                  60                  


His Pro Asp Leu Gly Glu Pro Phe Gly Val Met Arg Cys Val Leu Cys 
65                  70                  75                  80  


Ala Cys Glu Ala Pro Gln Trp Gly Arg Arg Xaa Arg Gly Pro Gly Arg 
                85                  90                  95      


Val Ser Cys Lys Asn Ile Lys Pro Glu Cys Pro Xaa Pro Ala Cys Gly 
            100                 105                 110         


Gln Pro Arg Gln Leu Pro Gly His Cys Cys Gln Xaa Cys Pro Gln Glu 
        115                 120                 125             


Arg Ser Ser Ser Glu Arg Gln Pro Ser Gly Leu Ser Phe Glu Tyr Pro 
    130                 135                 140                 


Arg Asp Pro Glu His Arg Ser Tyr Ser Asp Arg Gly Glu Pro Gly Ala 
145                 150                 155                 160 


Glu Glu Arg Ala Arg Gly Asp Gly His Xaa Asp Phe Val Ala Leu Leu 
                165                 170                 175     


Xaa Gly Pro Arg Ser Gln Ala Val Ala Arg Ala Arg Val Ser Leu Leu 
            180                 185                 190         


Arg Ser Ser Leu Arg Phe Ser Ile Ser Tyr Arg Arg Leu Asp Arg Pro 
        195                 200                 205             


Xaa Arg Ile Arg Phe Ser Asp Ser Asn Gly Ser Val Leu Phe Glu His 
    210                 215                 220                 


Pro Ala Ala Pro Xaa Gln Asp Gly Leu Val Cys Gly Val Trp Arg Ala 
225                 230                 235                 240 


Val Pro Arg Leu Ser Leu Arg Leu Leu Arg Ala Glu Gln Leu His Val 
                245                 250                 255     


Ala Leu Val Xaa Leu Xaa His Pro Ser Gly Glu Val Trp Gly Pro Leu 
            260                 265                 270         


Ile Arg His Arg Ala Leu Ala Ala Glu Xaa Phe Ser Ala Ile Leu Xaa 
        275                 280                 285             


Leu Glu Gly Pro Pro Gln Gln Gly Val Gly Gly Ile Xaa Leu Leu Xaa 
    290                 295                 300                 


Leu Ser Asp Xaa Glu Asp Ser Leu His Phe Leu Leu Leu Phe Arg Gly 
305                 310                 315                 320 


Leu Leu Glu Pro Arg Ser Gly Gly Leu Xaa Gln Val Pro Leu Arg Leu 
                325                 330                 335     


Gln Ile Leu His Gln Gly Gln Leu Leu Arg Glu Leu Gln Ala Asn Val 
            340                 345                 350         


Ser Ala Gln Glu Pro Gly Phe Ala Glu Val Leu Pro Asn Leu Xaa Val 
        355                 360                 365             


Gln Glu Met Asp Trp Leu Val Leu Gly Glu Leu Gln Met Ala Leu Glu 
    370                 375                 380                 


Trp Ala Gly Arg Pro Gly Leu Arg Ile Ser Gly His Ile Ala Ala Arg 
385                 390                 395                 400 


Lys Ser Cys Asp Val Leu Gln Ser Val Leu Cys Gly Ala Asp Ala Leu 
                405                 410                 415     


Ile Pro Val Gln Xaa Gly Ala Ala Gly Ser Ala Ser Leu Xaa Leu Leu 
            420                 425                 430         


Gly Asn Gly Ser Leu Ile Tyr Gln Ala Val Gly Ile Cys Pro Gly Leu 
        435                 440                 445             


Gly Ala Arg Gly Ala His Met Leu Leu Gln Asn Glu Leu Phe Leu Asn 
    450                 455                 460                 


Val Gly Xaa Lys Asp Phe Pro Asp Gly Glu Leu Arg Gly His Val Ala 
465                 470                 475                 480 


Ala Leu Pro Tyr Cys Gly His Ser Ala Arg His Asp Xaa Leu Pro Val 
                485                 490                 495     


Pro Leu Ala Gly Ala Leu Val Leu Pro Pro Val Lys Ser Gln Ala Ala 
            500                 505                 510         


Gly His Ala Trp Leu Ser Leu Asp Xaa His Cys His Leu His Tyr Glu 
        515                 520                 525             


Val Leu Leu Ala Gly Leu Gly Gly Ser Glu Gln Gly Xaa Val Xaa Ala 
    530                 535                 540                 


His Leu Leu Gly Pro Pro Gly Xaa Pro Gly Pro Arg Arg Leu Leu Lys 
545                 550                 555                 560 


Gly Phe Tyr Gly Ser Glu Ala Gln Gly Val Val Lys Asp Leu Glu Pro 
                565                 570                 575     


Glu Leu Leu Arg His Leu Ala Lys Gly Met Ala Ser Leu Met Ile Xaa 
            580                 585                 590         


Xaa Lys Gly Ser Pro Arg Gly Glu Leu Arg Gly Gln Val His Ile Ala 
        595                 600                 605             


Asn Gln Cys Glu Val Gly Gly Leu Arg Leu Glu Ala Ala Gly Ala Glu 
    610                 615                 620                 


Gly Val Arg Ala Leu Gly Ala Pro Asp Xaa Ala Ser Ala Ala Pro Pro 
625                 630                 635                 640 


Val Val Pro Gly Leu Pro Ala Leu Ala Pro Ala Lys Pro Gly Gly Pro 
                645                 650                 655     


Gly Arg Pro Arg Asp Pro Asn Xaa Cys Phe Phe Glu Gly Gln Gln Arg 
            660                 665                 670         


Pro His Gly Ala Arg Trp Ala Pro Asn Tyr Asp Pro Leu Cys Ser Leu 
        675                 680                 685             


Cys Xaa Cys Gln Arg Arg Xaa Val Ile Cys Asp Pro Val Val Cys Pro 
    690                 695                 700                 


Pro Pro Ser Cys Pro His Pro Val Gln Ala Pro Asp Gln Cys Cys Pro 
705                 710                 715                 720 


Val Cys Pro Glu Lys Gln Asp Val Arg Asp Leu Pro Gly Leu Pro Arg 
                725                 730                 735     


Ser Arg Asp Pro Gly Glu Gly Cys Tyr Phe Asp Gly Asp Arg Ser Trp 
            740                 745                 750         


Arg Ala Ala Gly Xaa Arg Trp His Pro Val Val Pro Pro Phe Gly Leu 
        755                 760                 765             


Ile Lys Cys Ala Val Cys Xaa Cys Lys Gly Gly Xaa Gly Glu Val His 
    770                 775                 780                 


Cys Glu Lys Val Gln Cys Pro Arg Leu Ala Cys Ala Gln Pro Val Arg 
785                 790                 795                 800 


Val Asn Pro Xaa Asp Cys Cys Lys Gln Cys Pro Val Gly Ser Gly Ala 
                805                 810                 815     


His Pro Gln Leu Gly Asp Pro Met Gln Ala Asp Gly Pro Arg Gly Cys 
            820                 825                 830         


Arg Phe Ala Gly Gln Trp Phe Pro Glu Ser Gln Ser Trp His Pro Ser 
        835                 840                 845             


Val Pro Pro Phe Gly Glu Met Ser Cys Ile Xaa Cys Arg Cys Gly Ala 
    850                 855                 860                 


Gly Val Pro His Cys Glu Arg Asp Asp Cys Ser Leu Pro Leu Ser Cys 
865                 870                 875                 880 


Gly Ser Gly Lys Glu Ser Arg Cys Cys Ser Arg Cys Xaa Ala His Arg 
                885                 890                 895     


Arg Pro Ala Pro Glu Xaa Arg Xaa Asp Pro Glu Leu Glu Lys Glu Ala 
            900                 905                 910         


Glu Gly Ser 
        915 


<210> 6125
<211> 954
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<400> 6125
Met Pro Ser Leu Pro Ala Pro Pro Ala Pro Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ser Arg Pro Ala Arg Gly Ala Gly Pro Glu Pro Pro 
            20                  25                  30          


Val Leu Pro Ile Arg Ser Glu Lys Glu Pro Leu Pro Val Arg Gly Ala 
        35                  40                  45              


Ala Gly Cys Xaa Phe Gly Gly Lys Val Tyr Ala Leu Asp Glu Xaa Trp 
    50                  55                  60                  


His Pro Asp Leu Gly Glu Pro Phe Gly Val Met Arg Cys Val Leu Cys 
65                  70                  75                  80  


Ala Cys Glu Ala Pro Gln Trp Gly Arg Arg Xaa Arg Gly Pro Gly Arg 
                85                  90                  95      


Val Ser Cys Lys Asn Ile Lys Pro Glu Cys Pro Xaa Pro Ala Cys Gly 
            100                 105                 110         


Gln Pro Arg Gln Leu Pro Gly His Cys Cys Gln Xaa Cys Pro Gln Glu 
        115                 120                 125             


Arg Ser Ser Ser Glu Arg Gln Pro Ser Gly Leu Ser Phe Glu Tyr Pro 
    130                 135                 140                 


Arg Asp Pro Glu His Arg Ser Tyr Ser Asp Arg Gly Glu Pro Gly Ala 
145                 150                 155                 160 


Glu Glu Arg Ala Arg Gly Asp Gly His Xaa Asp Phe Val Ala Leu Leu 
                165                 170                 175     


Xaa Gly Pro Arg Ser Gln Ala Val Ala Arg Ala Arg Val Ser Leu Leu 
            180                 185                 190         


Arg Ser Ser Leu Arg Phe Ser Ile Ser Tyr Arg Arg Leu Asp Arg Pro 
        195                 200                 205             


Xaa Arg Ile Arg Phe Ser Asp Ser Asn Gly Ser Val Leu Phe Glu His 
    210                 215                 220                 


Pro Ala Ala Pro Xaa Gln Asp Gly Leu Val Cys Gly Val Trp Arg Ala 
225                 230                 235                 240 


Val Pro Arg Leu Ser Leu Arg Leu Leu Arg Ala Glu Gln Leu His Val 
                245                 250                 255     


Ala Leu Val Xaa Leu Xaa His Pro Ser Gly Glu Val Trp Gly Pro Leu 
            260                 265                 270         


Ile Arg His Arg Ala Leu Ala Ala Glu Xaa Phe Ser Ala Ile Leu Xaa 
        275                 280                 285             


Leu Glu Gly Pro Pro Gln Gln Gly Val Gly Gly Ile Xaa Leu Leu Xaa 
    290                 295                 300                 


Leu Ser Asp Xaa Glu Asp Ser Leu His Phe Leu Leu Leu Phe Arg Gly 
305                 310                 315                 320 


Leu Leu Glu Pro Arg Ser Gly Gly Leu Xaa Gln Val Pro Leu Arg Leu 
                325                 330                 335     


Gln Ile Leu His Gln Gly Gln Leu Leu Arg Glu Leu Gln Ala Asn Val 
            340                 345                 350         


Ser Ala Gln Glu Pro Gly Phe Ala Glu Val Leu Pro Asn Leu Xaa Val 
        355                 360                 365             


Gln Glu Met Asp Trp Leu Val Leu Gly Glu Leu Gln Met Ala Leu Glu 
    370                 375                 380                 


Trp Ala Gly Arg Pro Gly Leu Arg Ile Ser Gly His Ile Ala Ala Arg 
385                 390                 395                 400 


Lys Ser Cys Asp Val Leu Gln Ser Val Leu Cys Gly Ala Asp Ala Leu 
                405                 410                 415     


Ile Pro Val Gln Xaa Gly Ala Ala Gly Ser Ala Ser Leu Xaa Leu Leu 
            420                 425                 430         


Gly Asn Gly Ser Leu Ile Tyr Gln Val Gln Val Val Gly Xaa Ser Ser 
        435                 440                 445             


Glu Val Val Ala Met Xaa Leu Glu Xaa Lys Pro Gln Arg Arg Asp Gln 
    450                 455                 460                 


Arg Xaa Val Leu Cys His Met Ala Gly Leu Gln Pro Gly Gly His Xaa 
465                 470                 475                 480 


Ala Val Gly Ile Cys Pro Gly Leu Gly Ala Arg Gly Ala His Met Leu 
                485                 490                 495     


Leu Gln Asn Glu Leu Phe Leu Asn Val Gly Xaa Lys Asp Phe Pro Asp 
            500                 505                 510         


Gly Glu Leu Arg Gly His Val Ala Ala Leu Pro Tyr Cys Gly His Ser 
        515                 520                 525             


Ala Arg His Asp Xaa Leu Pro Val Pro Leu Ala Gly Ala Leu Val Leu 
    530                 535                 540                 


Pro Pro Val Lys Ser Gln Ala Ala Gly His Ala Trp Leu Ser Leu Asp 
545                 550                 555                 560 


Xaa His Cys His Leu His Tyr Glu Val Leu Leu Ala Gly Leu Gly Gly 
                565                 570                 575     


Ser Glu Gln Gly Xaa Val Xaa Ala His Leu Leu Gly Pro Pro Gly Xaa 
            580                 585                 590         


Pro Gly Pro Arg Arg Leu Leu Lys Gly Phe Tyr Gly Ser Glu Ala Gln 
        595                 600                 605             


Gly Val Val Lys Asp Leu Glu Pro Glu Leu Leu Arg His Leu Ala Lys 
    610                 615                 620                 


Gly Met Ala Ser Leu Met Ile Xaa Xaa Lys Gly Ser Pro Arg Gly Glu 
625                 630                 635                 640 


Leu Arg Gly Gln Val His Ile Ala Asn Gln Cys Glu Val Gly Gly Leu 
                645                 650                 655     


Arg Leu Glu Ala Ala Gly Ala Glu Gly Val Arg Ala Leu Gly Ala Pro 
            660                 665                 670         


Asp Xaa Ala Ser Ala Ala Pro Pro Val Val Pro Gly Leu Pro Ala Leu 
        675                 680                 685             


Ala Pro Ala Lys Pro Gly Gly Pro Gly Arg Pro Arg Asp Pro Asn Xaa 
    690                 695                 700                 


Cys Phe Phe Glu Gly Gln Gln Arg Pro His Gly Ala Arg Trp Ala Pro 
705                 710                 715                 720 


Asn Tyr Asp Pro Leu Cys Ser Leu Cys Xaa Cys Gln Arg Arg Xaa Val 
                725                 730                 735     


Ile Cys Asp Pro Val Val Cys Pro Pro Pro Ser Cys Pro His Pro Val 
            740                 745                 750         


Gln Ala Pro Asp Gln Cys Cys Pro Val Cys Pro Glu Lys Gln Asp Val 
        755                 760                 765             


Arg Asp Leu Pro Gly Leu Pro Arg Ser Arg Asp Pro Gly Glu Gly Cys 
    770                 775                 780                 


Tyr Phe Asp Gly Asp Arg Ser Trp Arg Ala Ala Gly Xaa Arg Trp His 
785                 790                 795                 800 


Pro Val Val Pro Pro Phe Gly Leu Ile Lys Cys Ala Val Cys Xaa Cys 
                805                 810                 815     


Lys Gly Gly Xaa Gly Glu Val His Cys Glu Lys Val Gln Cys Pro Arg 
            820                 825                 830         


Leu Ala Cys Ala Gln Pro Val Arg Val Asn Pro Xaa Asp Cys Cys Lys 
        835                 840                 845             


Gln Cys Pro Val Gly Ser Gly Ala His Pro Gln Leu Gly Asp Pro Met 
    850                 855                 860                 


Gln Ala Asp Gly Pro Arg Gly Cys Arg Phe Ala Gly Gln Trp Phe Pro 
865                 870                 875                 880 


Glu Ser Gln Ser Trp His Pro Ser Val Pro Pro Phe Gly Glu Met Ser 
                885                 890                 895     


Cys Ile Xaa Cys Arg Cys Gly Ala Gly Val Pro His Cys Glu Arg Asp 
            900                 905                 910         


Asp Cys Ser Leu Pro Leu Ser Cys Gly Ser Gly Lys Glu Ser Arg Cys 
        915                 920                 925             


Cys Ser Arg Cys Xaa Ala His Arg Arg Pro Pro Glu Xaa Arg Xaa Asp 
    930                 935                 940                 


Pro Glu Leu Glu Lys Glu Ala Glu Gly Ser 
945                 950                 


<210> 6126
<211> 955
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<400> 6126
Met Pro Ser Leu Pro Ala Pro Pro Ala Pro Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ser Arg Pro Ala Arg Gly Ala Gly Pro Glu Pro Pro 
            20                  25                  30          


Val Leu Pro Ile Arg Ser Glu Lys Glu Pro Leu Pro Val Arg Gly Ala 
        35                  40                  45              


Ala Gly Cys Xaa Phe Gly Gly Lys Val Tyr Ala Leu Asp Glu Xaa Trp 
    50                  55                  60                  


His Pro Asp Leu Gly Glu Pro Phe Gly Val Met Arg Cys Val Leu Cys 
65                  70                  75                  80  


Ala Cys Glu Ala Pro Gln Trp Gly Arg Arg Xaa Arg Gly Pro Gly Arg 
                85                  90                  95      


Val Ser Cys Lys Asn Ile Lys Pro Glu Cys Pro Xaa Pro Ala Cys Gly 
            100                 105                 110         


Gln Pro Arg Gln Leu Pro Gly His Cys Cys Gln Xaa Cys Pro Gln Glu 
        115                 120                 125             


Arg Ser Ser Ser Glu Arg Gln Pro Ser Gly Leu Ser Phe Glu Tyr Pro 
    130                 135                 140                 


Arg Asp Pro Glu His Arg Ser Tyr Ser Asp Arg Gly Glu Pro Gly Ala 
145                 150                 155                 160 


Glu Glu Arg Ala Arg Gly Asp Gly His Xaa Asp Phe Val Ala Leu Leu 
                165                 170                 175     


Xaa Gly Pro Arg Ser Gln Ala Val Ala Arg Ala Arg Val Ser Leu Leu 
            180                 185                 190         


Arg Ser Ser Leu Arg Phe Ser Ile Ser Tyr Arg Arg Leu Asp Arg Pro 
        195                 200                 205             


Xaa Arg Ile Arg Phe Ser Asp Ser Asn Gly Ser Val Leu Phe Glu His 
    210                 215                 220                 


Pro Ala Ala Pro Xaa Gln Asp Gly Leu Val Cys Gly Val Trp Arg Ala 
225                 230                 235                 240 


Val Pro Arg Leu Ser Leu Arg Leu Leu Arg Ala Glu Gln Leu His Val 
                245                 250                 255     


Ala Leu Val Xaa Leu Xaa His Pro Ser Gly Glu Val Trp Gly Pro Leu 
            260                 265                 270         


Ile Arg His Arg Ala Leu Ala Ala Glu Xaa Phe Ser Ala Ile Leu Xaa 
        275                 280                 285             


Leu Glu Gly Pro Pro Gln Gln Gly Val Gly Gly Ile Xaa Leu Leu Xaa 
    290                 295                 300                 


Leu Ser Asp Xaa Glu Asp Ser Leu His Phe Leu Leu Leu Phe Arg Gly 
305                 310                 315                 320 


Leu Leu Glu Pro Arg Ser Gly Gly Leu Xaa Gln Val Pro Leu Arg Leu 
                325                 330                 335     


Gln Ile Leu His Gln Gly Gln Leu Leu Arg Glu Leu Gln Ala Asn Val 
            340                 345                 350         


Ser Ala Gln Glu Pro Gly Phe Ala Glu Val Leu Pro Asn Leu Xaa Val 
        355                 360                 365             


Gln Glu Met Asp Trp Leu Val Leu Gly Glu Leu Gln Met Ala Leu Glu 
    370                 375                 380                 


Trp Ala Gly Arg Pro Gly Leu Arg Ile Ser Gly His Ile Ala Ala Arg 
385                 390                 395                 400 


Lys Ser Cys Asp Val Leu Gln Ser Val Leu Cys Gly Ala Asp Ala Leu 
                405                 410                 415     


Ile Pro Val Gln Xaa Gly Ala Ala Gly Ser Ala Ser Leu Xaa Leu Leu 
            420                 425                 430         


Gly Asn Gly Ser Leu Ile Tyr Gln Val Gln Val Val Gly Xaa Ser Ser 
        435                 440                 445             


Glu Val Val Ala Met Xaa Leu Glu Xaa Lys Pro Gln Arg Arg Asp Gln 
    450                 455                 460                 


Arg Xaa Val Leu Cys His Met Ala Gly Leu Gln Pro Gly Gly His Xaa 
465                 470                 475                 480 


Ala Val Gly Ile Cys Pro Gly Leu Gly Ala Arg Gly Ala His Met Leu 
                485                 490                 495     


Leu Gln Asn Glu Leu Phe Leu Asn Val Gly Xaa Lys Asp Phe Pro Asp 
            500                 505                 510         


Gly Glu Leu Arg Gly His Val Ala Ala Leu Pro Tyr Cys Gly His Ser 
        515                 520                 525             


Ala Arg His Asp Xaa Leu Pro Val Pro Leu Ala Gly Ala Leu Val Leu 
    530                 535                 540                 


Pro Pro Val Lys Ser Gln Ala Ala Gly His Ala Trp Leu Ser Leu Asp 
545                 550                 555                 560 


Xaa His Cys His Leu His Tyr Glu Val Leu Leu Ala Gly Leu Gly Gly 
                565                 570                 575     


Ser Glu Gln Gly Xaa Val Xaa Ala His Leu Leu Gly Pro Pro Gly Xaa 
            580                 585                 590         


Pro Gly Pro Arg Arg Leu Leu Lys Gly Phe Tyr Gly Ser Glu Ala Gln 
        595                 600                 605             


Gly Val Val Lys Asp Leu Glu Pro Glu Leu Leu Arg His Leu Ala Lys 
    610                 615                 620                 


Gly Met Ala Ser Leu Met Ile Xaa Xaa Lys Gly Ser Pro Arg Gly Glu 
625                 630                 635                 640 


Leu Arg Gly Gln Val His Ile Ala Asn Gln Cys Glu Val Gly Gly Leu 
                645                 650                 655     


Arg Leu Glu Ala Ala Gly Ala Glu Gly Val Arg Ala Leu Gly Ala Pro 
            660                 665                 670         


Asp Xaa Ala Ser Ala Ala Pro Pro Val Val Pro Gly Leu Pro Ala Leu 
        675                 680                 685             


Ala Pro Ala Lys Pro Gly Gly Pro Gly Arg Pro Arg Asp Pro Asn Xaa 
    690                 695                 700                 


Cys Phe Phe Glu Gly Gln Gln Arg Pro His Gly Ala Arg Trp Ala Pro 
705                 710                 715                 720 


Asn Tyr Asp Pro Leu Cys Ser Leu Cys Xaa Cys Gln Arg Arg Xaa Val 
                725                 730                 735     


Ile Cys Asp Pro Val Val Cys Pro Pro Pro Ser Cys Pro His Pro Val 
            740                 745                 750         


Gln Ala Pro Asp Gln Cys Cys Pro Val Cys Pro Glu Lys Gln Asp Val 
        755                 760                 765             


Arg Asp Leu Pro Gly Leu Pro Arg Ser Arg Asp Pro Gly Glu Gly Cys 
    770                 775                 780                 


Tyr Phe Asp Gly Asp Arg Ser Trp Arg Ala Ala Gly Xaa Arg Trp His 
785                 790                 795                 800 


Pro Val Val Pro Pro Phe Gly Leu Ile Lys Cys Ala Val Cys Xaa Cys 
                805                 810                 815     


Lys Gly Gly Xaa Gly Glu Val His Cys Glu Lys Val Gln Cys Pro Arg 
            820                 825                 830         


Leu Ala Cys Ala Gln Pro Val Arg Val Asn Pro Xaa Asp Cys Cys Lys 
        835                 840                 845             


Gln Cys Pro Val Gly Ser Gly Ala His Pro Gln Leu Gly Asp Pro Met 
    850                 855                 860                 


Gln Ala Asp Gly Pro Arg Gly Cys Arg Phe Ala Gly Gln Trp Phe Pro 
865                 870                 875                 880 


Glu Ser Gln Ser Trp His Pro Ser Val Pro Pro Phe Gly Glu Met Ser 
                885                 890                 895     


Cys Ile Xaa Cys Arg Cys Gly Ala Gly Val Pro His Cys Glu Arg Asp 
            900                 905                 910         


Asp Cys Ser Leu Pro Leu Ser Cys Gly Ser Gly Lys Glu Ser Arg Cys 
        915                 920                 925             


Cys Ser Arg Cys Xaa Ala His Arg Arg Pro Ala Pro Glu Xaa Arg Xaa 
    930                 935                 940                 


Asp Pro Glu Leu Glu Lys Glu Ala Glu Gly Ser 
945                 950                 955 


<210> 6127
<211> 94
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<400> 6127
Met Pro Ser Leu Pro Ala Pro Pro Ala Pro Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ser Arg Pro Ala Arg Gly Ala Gly Pro Glu Pro Pro 
            20                  25                  30          


Val Leu Pro Ile Arg Ser Glu Lys Glu Pro Leu Pro Val Arg Gly Ala 
        35                  40                  45              


Ala Gly Cys Xaa Phe Gly Gly Lys Val Tyr Ala Leu Asp Glu Xaa Trp 
    50                  55                  60                  


His Pro Asp Leu Gly Glu Pro Phe Gly Val Met Arg Cys Val Leu Cys 
65                  70                  75                  80  


Ala Cys Glu Ala Xaa Gly Xaa Leu Arg Pro Arg Glu Met Lys 
                85                  90                  


<210> 6128
<211> 450
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<400> 6128
Met Gly Gly Met Lys Tyr Ile Phe Ser Leu Leu Phe Phe Leu Leu Leu 
1               5                   10                  15      


Glu Gly Gly Lys Xaa Glu Gln Val Lys His Ser Glu Xaa Tyr Cys Met 
            20                  25                  30          


Phe Gln Asp Lys Lys Tyr Arg Val Gly Glu Arg Trp His Pro Tyr Leu 
        35                  40                  45              


Glu Pro Tyr Gly Leu Val Tyr Cys Val Asn Cys Ile Cys Ser Glu Asn 
    50                  55                  60                  


Gly Asn Val Leu Cys Ser Arg Val Arg Cys Pro Asn Val His Cys Leu 
65                  70                  75                  80  


Ser Pro Val His Ile Pro His Leu Cys Cys Pro Arg Cys Pro Asp Ser 
                85                  90                  95      


Leu Pro Pro Val Asn Asn Lys Val Xaa Ser Lys Ser Cys Glu Tyr Asn 
            100                 105                 110         


Gly Xaa Xaa Tyr Gln His Gly Glu Leu Phe Val Ala Glu Gly Leu Phe 
        115                 120                 125             


Gln Asn Arg Gln Pro Asn Gln Cys Xaa Gln Cys Ser Cys Ser Glu Gly 
    130                 135                 140                 


Asn Val Tyr Cys Gly Leu Lys Xaa Cys Pro Lys Leu Xaa Cys Ala Phe 
145                 150                 155                 160 


Pro Val Ser Val Pro Asp Ser Cys Cys Arg Val Cys Arg Gly Asp Gly 
                165                 170                 175     


Glu Leu Ser Trp Glu His Ser Asp Gly Asp Ile Phe Arg Gln Pro Ala 
            180                 185                 190         


Asn Arg Glu Ala Arg His Ser Tyr His Arg Ser His Tyr Asp Pro Pro 
        195                 200                 205             


Pro Ser Arg Gln Ala Gly Gly Leu Ser Arg Phe Pro Gly Ala Arg Ser 
    210                 215                 220                 


His Arg Gly Ala Leu Met Asp Ser Gln Gln Ala Ser Gly Xaa Ile Val 
225                 230                 235                 240 


Gln Ile Val Ile Asn Asn Lys His Lys His Gly Gln Val Cys Val Ser 
                245                 250                 255     


Asn Gly Lys Xaa Tyr Ser His Gly Glu Ser Trp His Pro Asn Leu Arg 
            260                 265                 270         


Ala Phe Gly Ile Val Glu Cys Val Leu Cys Xaa Cys Asn Val Xaa Lys 
        275                 280                 285             


Gln Glu Cys Lys Lys Ile His Cys Pro Asn Arg Tyr Pro Cys Lys Tyr 
    290                 295                 300                 


Pro Gln Lys Ile Asp Gly Lys Cys Cys Lys Val Cys Pro Gly Lys Lys 
305                 310                 315                 320 


Ala Lys Glu Leu Pro Gly Gln Ser Phe Asp Asn Lys Gly Tyr Phe Cys 
                325                 330                 335     


Gly Glu Glu Xaa Met Pro Val Tyr Glu Ser Val Phe Met Glu Asp Gly 
            340                 345                 350         


Glu Xaa Xaa Arg Lys Ile Ala Leu Glu Xaa Glu Arg Pro Pro Gln Val 
        355                 360                 365             


Glu Val His Val Trp Xaa Ile Arg Lys Gly Ile Leu Gln His Phe His 
    370                 375                 380                 


Ile Glu Lys Ile Ser Lys Arg Met Phe Glu Glu Leu Pro His Phe Lys 
385                 390                 395                 400 


Leu Val Xaa Arg Xaa Xaa Leu Ser Gln Trp Lys Ile Phe Xaa Glu Gly 
                405                 410                 415     


Glu Ala Gln Ile Ser Gln Met Cys Ser Ser Arg Val Cys Arg Xaa Glu 
            420                 425                 430         


Leu Glu Asp Leu Val Lys Val Leu Tyr Leu Glu Arg Ser Glu Lys Gly 
        435                 440                 445             


His Cys 
    450 


<210> 6129
<211> 456
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<400> 6129
Met Arg Lys Lys Trp Lys Met Gly Gly Met Lys Tyr Ile Phe Ser Leu 
1               5                   10                  15      


Leu Phe Phe Leu Leu Leu Glu Gly Gly Lys Xaa Glu Gln Val Lys His 
            20                  25                  30          


Ser Glu Xaa Tyr Cys Met Phe Gln Asp Lys Lys Tyr Arg Val Gly Glu 
        35                  40                  45              


Arg Trp His Pro Tyr Leu Glu Pro Tyr Gly Leu Val Tyr Cys Val Asn 
    50                  55                  60                  


Cys Ile Cys Ser Glu Asn Gly Asn Val Leu Cys Ser Arg Val Arg Cys 
65                  70                  75                  80  


Pro Asn Val His Cys Leu Ser Pro Val His Ile Pro His Leu Cys Cys 
                85                  90                  95      


Pro Arg Cys Pro Asp Ser Leu Pro Pro Val Asn Asn Lys Val Xaa Ser 
            100                 105                 110         


Lys Ser Cys Glu Tyr Asn Gly Xaa Xaa Tyr Gln His Gly Glu Leu Phe 
        115                 120                 125             


Val Ala Glu Gly Leu Phe Gln Asn Arg Gln Pro Asn Gln Cys Xaa Gln 
    130                 135                 140                 


Cys Ser Cys Ser Glu Gly Asn Val Tyr Cys Gly Leu Lys Xaa Cys Pro 
145                 150                 155                 160 


Lys Leu Xaa Cys Ala Phe Pro Val Ser Val Pro Asp Ser Cys Cys Arg 
                165                 170                 175     


Val Cys Arg Gly Asp Gly Glu Leu Ser Trp Glu His Ser Asp Gly Asp 
            180                 185                 190         


Ile Phe Arg Gln Pro Ala Asn Arg Glu Ala Arg His Ser Tyr His Arg 
        195                 200                 205             


Ser His Tyr Asp Pro Pro Pro Ser Arg Gln Ala Gly Gly Leu Ser Arg 
    210                 215                 220                 


Phe Pro Gly Ala Arg Ser His Arg Gly Ala Leu Met Asp Ser Gln Gln 
225                 230                 235                 240 


Ala Ser Gly Xaa Ile Val Gln Ile Val Ile Asn Asn Lys His Lys His 
                245                 250                 255     


Gly Gln Val Cys Val Ser Asn Gly Lys Xaa Tyr Ser His Gly Glu Ser 
            260                 265                 270         


Trp His Pro Asn Leu Arg Ala Phe Gly Ile Val Glu Cys Val Leu Cys 
        275                 280                 285             


Xaa Cys Asn Val Xaa Lys Gln Glu Cys Lys Lys Ile His Cys Pro Asn 
    290                 295                 300                 


Arg Tyr Pro Cys Lys Tyr Pro Gln Lys Ile Asp Gly Lys Cys Cys Lys 
305                 310                 315                 320 


Val Cys Pro Gly Lys Lys Ala Lys Glu Leu Pro Gly Gln Ser Phe Asp 
                325                 330                 335     


Asn Lys Gly Tyr Phe Cys Gly Glu Glu Xaa Met Pro Val Tyr Glu Ser 
            340                 345                 350         


Val Phe Met Glu Asp Gly Glu Xaa Xaa Arg Lys Ile Ala Leu Glu Xaa 
        355                 360                 365             


Glu Arg Pro Pro Gln Val Glu Val His Val Trp Xaa Ile Arg Lys Gly 
    370                 375                 380                 


Ile Leu Gln His Phe His Ile Glu Lys Ile Ser Lys Arg Met Phe Glu 
385                 390                 395                 400 


Glu Leu Pro His Phe Lys Leu Val Xaa Arg Xaa Xaa Leu Ser Gln Trp 
                405                 410                 415     


Lys Ile Phe Xaa Glu Gly Glu Ala Gln Ile Ser Gln Met Cys Ser Ser 
            420                 425                 430         


Arg Val Cys Arg Xaa Glu Leu Glu Asp Leu Val Lys Val Leu Tyr Leu 
        435                 440                 445             


Glu Arg Ser Glu Lys Gly His Cys 
    450                 455     


<210> 6130
<211> 457
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<400> 6130
Met Arg Lys Lys Trp Lys Met Gly Gly Met Lys Tyr Ile Phe Ser Leu 
1               5                   10                  15      


Leu Phe Phe Leu Leu Leu Glu Gly Gly Lys Xaa Glu Gln Val Lys His 
            20                  25                  30          


Ser Glu Xaa Tyr Cys Met Phe Gln Asp Lys Lys Tyr Arg Val Gly Glu 
        35                  40                  45              


Arg Trp His Pro Tyr Leu Glu Pro Tyr Gly Leu Val Tyr Cys Val Asn 
    50                  55                  60                  


Cys Ile Cys Ser Glu Asn Gly Asn Val Leu Cys Ser Arg Val Arg Cys 
65                  70                  75                  80  


Pro Asn Val His Cys Leu Ser Pro Val His Ile Pro His Leu Cys Cys 
                85                  90                  95      


Pro Arg Cys Pro Asp Ser Leu Pro Pro Val Asn Asn Lys Val Xaa Ser 
            100                 105                 110         


Lys Ser Cys Glu Tyr Asn Gly Xaa Xaa Tyr Gln His Gly Glu Leu Phe 
        115                 120                 125             


Val Ala Glu Gly Leu Phe Gln Asn Arg Gln Pro Asn Gln Cys Xaa Gln 
    130                 135                 140                 


Cys Ser Cys Ser Glu Gly Asn Val Tyr Cys Gly Leu Lys Xaa Cys Pro 
145                 150                 155                 160 


Lys Leu Xaa Cys Ala Phe Pro Val Ser Val Pro Asp Ser Cys Cys Arg 
                165                 170                 175     


Val Cys Arg Gly Asp Gly Glu Leu Ser Trp Glu His Ser Asp Gly Asp 
            180                 185                 190         


Ile Phe Arg Gln Pro Ala Asn Arg Glu Ala Arg His Ser Tyr His Arg 
        195                 200                 205             


Ser His Tyr Asp Pro Pro Pro Ser Arg Gln Ala Gly Gly Leu Ser Arg 
    210                 215                 220                 


Phe Pro Gly Ala Arg Ser His Arg Gly Ala Leu Met Asp Ser Gln Gln 
225                 230                 235                 240 


Ala Ser Gly Xaa Ile Val Gln Ile Val Ile Asn Asn Lys His Lys His 
                245                 250                 255     


Gly Gln Val Cys Val Ser Asn Gly Lys Xaa Tyr Ser His Gly Glu Ser 
            260                 265                 270         


Trp His Pro Asn Leu Arg Ala Phe Gly Ile Val Glu Cys Val Leu Cys 
        275                 280                 285             


Xaa Cys Asn Val Xaa Lys Gln Glu Cys Lys Lys Ile His Cys Pro Asn 
    290                 295                 300                 


Arg Tyr Pro Cys Lys Tyr Pro Gln Lys Ile Asp Gly Lys Cys Cys Lys 
305                 310                 315                 320 


Val Cys Pro Gly Lys Lys Ala Lys Glu Glu Leu Pro Gly Gln Ser Phe 
                325                 330                 335     


Asp Asn Lys Gly Tyr Phe Cys Gly Glu Glu Xaa Met Pro Val Tyr Glu 
            340                 345                 350         


Ser Val Phe Met Glu Asp Gly Glu Xaa Xaa Arg Lys Ile Ala Leu Glu 
        355                 360                 365             


Xaa Glu Arg Pro Pro Gln Val Glu Val His Val Trp Xaa Ile Arg Lys 
    370                 375                 380                 


Gly Ile Leu Gln His Phe His Ile Glu Lys Ile Ser Lys Arg Met Phe 
385                 390                 395                 400 


Glu Glu Leu Pro His Phe Lys Leu Val Xaa Arg Xaa Xaa Leu Ser Gln 
                405                 410                 415     


Trp Lys Ile Phe Xaa Glu Gly Glu Ala Gln Ile Ser Gln Met Cys Ser 
            420                 425                 430         


Ser Arg Val Cys Arg Xaa Glu Leu Glu Asp Leu Val Lys Val Leu Tyr 
        435                 440                 445             


Leu Glu Arg Ser Glu Lys Gly His Cys 
    450                 455         


<210> 6131
<211> 458
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<400> 6131
Met Arg Lys Lys Trp Lys Met Gly Gly Met Lys Tyr Ile Phe Ser Leu 
1               5                   10                  15      


Leu Phe Phe Leu Leu Leu Glu Gly Gly Lys Xaa Glu Gln Val Lys His 
            20                  25                  30          


Ser Glu Xaa Tyr Cys Met Phe Gln Asp Lys Lys Tyr Arg Val Gly Glu 
        35                  40                  45              


Arg Trp His Pro Tyr Leu Glu Pro Tyr Gly Leu Val Tyr Cys Val Asn 
    50                  55                  60                  


Cys Ile Cys Ser Glu Asn Gly Asn Val Leu Cys Ser Arg Val Arg Cys 
65                  70                  75                  80  


Pro Asn Val His Cys Leu Ser Pro Val His Ile Pro His Leu Cys Cys 
                85                  90                  95      


Pro Arg Cys Pro Glu Asp Ser Leu Pro Pro Val Asn Asn Lys Val Xaa 
            100                 105                 110         


Ser Lys Ser Cys Glu Tyr Asn Gly Xaa Xaa Tyr Gln His Gly Glu Leu 
        115                 120                 125             


Phe Val Ala Glu Gly Leu Phe Gln Asn Arg Gln Pro Asn Gln Cys Xaa 
    130                 135                 140                 


Gln Cys Ser Cys Ser Glu Gly Asn Val Tyr Cys Gly Leu Lys Xaa Cys 
145                 150                 155                 160 


Pro Lys Leu Xaa Cys Ala Phe Pro Val Ser Val Pro Asp Ser Cys Cys 
                165                 170                 175     


Arg Val Cys Arg Gly Asp Gly Glu Leu Ser Trp Glu His Ser Asp Gly 
            180                 185                 190         


Asp Ile Phe Arg Gln Pro Ala Asn Arg Glu Ala Arg His Ser Tyr His 
        195                 200                 205             


Arg Ser His Tyr Asp Pro Pro Pro Ser Arg Gln Ala Gly Gly Leu Ser 
    210                 215                 220                 


Arg Phe Pro Gly Ala Arg Ser His Arg Gly Ala Leu Met Asp Ser Gln 
225                 230                 235                 240 


Gln Ala Ser Gly Xaa Ile Val Gln Ile Val Ile Asn Asn Lys His Lys 
                245                 250                 255     


His Gly Gln Val Cys Val Ser Asn Gly Lys Xaa Tyr Ser His Gly Glu 
            260                 265                 270         


Ser Trp His Pro Asn Leu Arg Ala Phe Gly Ile Val Glu Cys Val Leu 
        275                 280                 285             


Cys Xaa Cys Asn Val Xaa Lys Gln Glu Cys Lys Lys Ile His Cys Pro 
    290                 295                 300                 


Asn Arg Tyr Pro Cys Lys Tyr Pro Gln Lys Ile Asp Gly Lys Cys Cys 
305                 310                 315                 320 


Lys Val Cys Pro Gly Lys Lys Ala Lys Glu Glu Leu Pro Gly Gln Ser 
                325                 330                 335     


Phe Asp Asn Lys Gly Tyr Phe Cys Gly Glu Glu Xaa Met Pro Val Tyr 
            340                 345                 350         


Glu Ser Val Phe Met Glu Asp Gly Glu Xaa Xaa Arg Lys Ile Ala Leu 
        355                 360                 365             


Glu Xaa Glu Arg Pro Pro Gln Val Glu Val His Val Trp Xaa Ile Arg 
    370                 375                 380                 


Lys Gly Ile Leu Gln His Phe His Ile Glu Lys Ile Ser Lys Arg Met 
385                 390                 395                 400 


Phe Glu Glu Leu Pro His Phe Lys Leu Val Xaa Arg Xaa Xaa Leu Ser 
                405                 410                 415     


Gln Trp Lys Ile Phe Xaa Glu Gly Glu Ala Gln Ile Ser Gln Met Cys 
            420                 425                 430         


Ser Ser Arg Val Cys Arg Xaa Glu Leu Glu Asp Leu Val Lys Val Leu 
        435                 440                 445             


Tyr Leu Glu Arg Ser Glu Lys Gly His Cys 
    450                 455             


<210> 6132
<211> 378
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<400> 6132
Met Arg Lys Lys Trp Lys Met Gly Gly Met Lys Tyr Ile Phe Ser Leu 
1               5                   10                  15      


Leu Phe Phe Leu Leu Leu Glu Gly Gly Lys Xaa Glu Gln Val Lys His 
            20                  25                  30          


Ser Glu Xaa Tyr Cys Met Phe Gln Asp Lys Lys Tyr Arg Val Gly Glu 
        35                  40                  45              


Arg Trp His Pro Tyr Leu Glu Pro Tyr Gly Leu Val Tyr Cys Val Asn 
    50                  55                  60                  


Cys Ile Cys Ser Glu Asn Gly Asn Val Leu Cys Ser Arg Val Arg Cys 
65                  70                  75                  80  


Pro Asn Val His Cys Leu Ser Pro Val His Ile Pro His Leu Cys Cys 
                85                  90                  95      


Pro Arg Cys Pro Gly Asp Gly Glu Leu Ser Trp Glu His Ser Asp Gly 
            100                 105                 110         


Asp Ile Phe Arg Gln Pro Ala Asn Arg Glu Ala Arg His Ser Tyr His 
        115                 120                 125             


Arg Ser His Tyr Asp Pro Pro Pro Ser Arg Gln Ala Gly Gly Leu Ser 
    130                 135                 140                 


Arg Phe Pro Gly Ala Arg Ser His Arg Gly Ala Leu Met Asp Ser Gln 
145                 150                 155                 160 


Gln Ala Ser Gly Xaa Ile Val Gln Ile Val Ile Asn Asn Lys His Lys 
                165                 170                 175     


His Gly Gln Val Cys Val Ser Asn Gly Lys Xaa Tyr Ser His Gly Glu 
            180                 185                 190         


Ser Trp His Pro Asn Leu Arg Ala Phe Gly Ile Val Glu Cys Val Leu 
        195                 200                 205             


Cys Xaa Cys Asn Val Xaa Lys Gln Glu Cys Lys Lys Ile His Cys Pro 
    210                 215                 220                 


Asn Arg Tyr Pro Cys Lys Tyr Pro Gln Lys Ile Asp Gly Lys Cys Cys 
225                 230                 235                 240 


Lys Val Cys Pro Gly Lys Lys Ala Lys Glu Glu Leu Pro Gly Gln Ser 
                245                 250                 255     


Phe Asp Asn Lys Gly Tyr Phe Cys Gly Glu Glu Xaa Met Pro Val Tyr 
            260                 265                 270         


Glu Ser Val Phe Met Glu Asp Gly Glu Xaa Xaa Arg Lys Ile Ala Leu 
        275                 280                 285             


Glu Xaa Glu Arg Pro Pro Gln Val Glu Val His Val Trp Xaa Ile Arg 
    290                 295                 300                 


Lys Gly Ile Leu Gln His Phe His Ile Glu Lys Ile Ser Lys Arg Met 
305                 310                 315                 320 


Phe Glu Glu Leu Pro His Phe Lys Leu Val Xaa Arg Xaa Xaa Leu Ser 
                325                 330                 335     


Gln Trp Lys Ile Phe Xaa Glu Gly Glu Ala Gln Ile Ser Gln Met Cys 
            340                 345                 350         


Ser Ser Arg Val Cys Arg Xaa Glu Leu Glu Asp Leu Val Lys Val Leu 
        355                 360                 365             


Tyr Leu Glu Arg Ser Glu Lys Gly His Cys 
    370                 375             


<210> 6133
<211> 134
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 6133
Met Asn Xaa Ser Ala Pro Pro Ala Val Ser Pro Asn Ile Xaa Val Leu 
1               5                   10                  15      


Ala Pro Gly Lys Gly Pro Trp Gln Val Ala Phe Ile Gly Ile Xaa Xaa 
            20                  25                  30          


Gly Leu Leu Ser Leu Ala Xaa Val Xaa Gly Asn Leu Leu Val Leu Ile 
        35                  40                  45              


Ser Phe Lys Val Asn Xaa Glu Leu Lys Xaa Val Asn Asn Tyr Phe Leu 
    50                  55                  60                  


Leu Ser Leu Ala Cys Ala Asp Leu Ile Ile Gly Xaa Phe Ser Met Asn 
65                  70                  75                  80  


Leu Tyr Xaa Xaa Tyr Leu Leu Met Gly His Trp Ala Leu Gly Xaa Leu 
                85                  90                  95      


Ala Cys Asp Leu Trp Leu Ala Leu Asp Tyr Val Ala Ser Asn Ala Ser 
            100                 105                 110         


Val Met Asn Leu Leu Leu Ile Ser Phe Asp Arg Tyr Phe Ser Val Xaa 
        115                 120                 125             


Arg Pro Leu Ser Tyr Arg 
    130                 


<210> 6134
<211> 454
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<400> 6134
Met Asn Xaa Ser Ala Pro Pro Ala Val Ser Pro Asn Ile Xaa Val Leu 
1               5                   10                  15      


Ala Pro Gly Lys Gly Pro Trp Gln Val Ala Phe Ile Gly Ile Xaa Xaa 
            20                  25                  30          


Gly Leu Leu Ser Leu Ala Xaa Val Xaa Gly Asn Leu Leu Val Leu Ile 
        35                  40                  45              


Ser Phe Lys Val Asn Xaa Glu Leu Lys Xaa Val Asn Asn Tyr Phe Leu 
    50                  55                  60                  


Leu Ser Leu Ala Cys Ala Asp Leu Ile Ile Gly Xaa Phe Ser Met Asn 
65                  70                  75                  80  


Leu Tyr Xaa Xaa Tyr Leu Leu Met Gly His Trp Ala Leu Gly Xaa Leu 
                85                  90                  95      


Ala Cys Asp Leu Trp Leu Ala Leu Asp Tyr Val Ala Ser Asn Ala Ser 
            100                 105                 110         


Val Met Asn Leu Leu Leu Ile Ser Phe Asp Arg Tyr Phe Ser Val Xaa 
        115                 120                 125             


Arg Pro Leu Ser Tyr Arg Ala Lys Arg Xaa Pro Arg Arg Ala Ala Leu 
    130                 135                 140                 


Met Ile Gly Leu Ala Trp Leu Val Ser Phe Val Leu Trp Ala Pro Ala 
145                 150                 155                 160 


Ile Leu Phe Trp Gln Tyr Leu Val Gly Glu Arg Xaa Val Leu Ala Gly 
                165                 170                 175     


Gln Cys Tyr Ile Gln Phe Leu Ser Gln Pro Ile Ile Xaa Phe Gly Xaa 
            180                 185                 190         


Ala Met Ala Ala Phe Tyr Leu Pro Val Xaa Val Met Cys Xaa Leu Tyr 
        195                 200                 205             


Trp Arg Ile Tyr Arg Glu Xaa Glu Asn Arg Ala Arg Glu Leu Ala Ala 
    210                 215                 220                 


Leu Gln Gly Ser Glu Xaa Pro Gly Lys Gly Gly Gly Ser Ser Ser Ser 
225                 230                 235                 240 


Ser Glu Arg Ser Gln Pro Gly Ala Glu Gly Ser Pro Glu Xaa Pro Pro 
                245                 250                 255     


Gly Arg Cys Cys Arg Cys Cys Arg Ala Pro Arg Leu Leu Gln Ala Tyr 
            260                 265                 270         


Ser Trp Lys Glu Glu Glu Glu Glu Asp Glu Gly Ser Met Glu Ser Leu 
        275                 280                 285             


Xaa Ser Ser Glu Gly Glu Glu Pro Gly Ser Glu Val Val Ile Lys Met 
    290                 295                 300                 


Pro Met Val Asp Pro Glu Ala Gln Ala Pro Xaa Lys Gln Pro Pro Arg 
305                 310                 315                 320 


Ser Ser Pro Asn Xaa Val Lys Arg Pro Xaa Lys Lys Gly Arg Asp Arg 
                325                 330                 335     


Ala Gly Lys Gly Gln Lys Pro Arg Gly Lys Glu Gln Leu Ala Lys Arg 
            340                 345                 350         


Lys Xaa Phe Ser Leu Val Lys Glu Lys Lys Ala Ala Arg Xaa Leu Ser 
        355                 360                 365             


Ala Ile Leu Leu Ala Phe Ile Leu Xaa Trp Xaa Pro Tyr Asn Ile Met 
    370                 375                 380                 


Val Leu Val Ser Xaa Phe Cys Lys Asp Cys Val Pro Glu Xaa Leu Trp 
385                 390                 395                 400 


Glu Leu Gly Tyr Trp Leu Cys Tyr Val Asn Ser Xaa Ile Asn Pro Met 
                405                 410                 415     


Cys Tyr Ala Leu Cys Asn Lys Ala Phe Arg Asp Xaa Phe Arg Leu Leu 
            420                 425                 430         


Leu Leu Cys Arg Trp Asp Lys Arg Arg Trp Arg Lys Ile Pro Lys Arg 
        435                 440                 445             


Pro Gly Ser Val His Arg 
    450                 


<210> 6135
<211> 460
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<400> 6135
Met Asn Xaa Ser Ala Pro Pro Ala Val Ser Pro Asn Ile Xaa Val Leu 
1               5                   10                  15      


Ala Pro Gly Lys Gly Pro Trp Gln Val Ala Phe Ile Gly Ile Xaa Xaa 
            20                  25                  30          


Gly Leu Leu Ser Leu Ala Xaa Val Xaa Gly Asn Leu Leu Val Leu Ile 
        35                  40                  45              


Ser Phe Lys Val Asn Xaa Glu Leu Lys Xaa Val Asn Asn Tyr Phe Leu 
    50                  55                  60                  


Leu Ser Leu Ala Cys Ala Asp Leu Ile Ile Gly Xaa Phe Ser Met Asn 
65                  70                  75                  80  


Leu Tyr Xaa Xaa Tyr Leu Leu Met Gly His Trp Ala Leu Gly Xaa Leu 
                85                  90                  95      


Ala Cys Asp Leu Trp Leu Ala Leu Asp Tyr Val Ala Ser Asn Ala Ser 
            100                 105                 110         


Val Met Asn Leu Leu Leu Ile Ser Phe Asp Arg Tyr Phe Ser Val Xaa 
        115                 120                 125             


Arg Pro Leu Ser Tyr Arg Ala Lys Arg Xaa Pro Arg Arg Ala Ala Leu 
    130                 135                 140                 


Met Ile Gly Leu Ala Trp Leu Val Ser Phe Val Leu Trp Ala Pro Ala 
145                 150                 155                 160 


Ile Leu Phe Trp Gln Tyr Leu Val Gly Glu Arg Xaa Val Leu Ala Gly 
                165                 170                 175     


Gln Cys Tyr Ile Gln Phe Leu Ser Gln Pro Ile Ile Xaa Phe Gly Xaa 
            180                 185                 190         


Ala Met Ala Ala Phe Tyr Leu Pro Val Xaa Val Met Cys Xaa Leu Tyr 
        195                 200                 205             


Trp Arg Ile Tyr Arg Glu Xaa Glu Asn Arg Ala Arg Glu Leu Ala Ala 
    210                 215                 220                 


Leu Gln Gly Ser Glu Xaa Pro Gly Lys Gly Gly Gly Ser Ser Ser Ser 
225                 230                 235                 240 


Ser Glu Arg Ser Gln Pro Gly Ala Glu Gly Ser Pro Glu Xaa Pro Pro 
                245                 250                 255     


Gly Arg Cys Cys Arg Cys Cys Arg Ala Pro Arg Leu Leu Gln Ala Tyr 
            260                 265                 270         


Ser Trp Lys Glu Glu Glu Glu Glu Asp Glu Gly Ser Met Glu Ser Leu 
        275                 280                 285             


Xaa Ser Ser Glu Gly Glu Glu Pro Gly Ser Glu Val Val Ile Lys Met 
    290                 295                 300                 


Pro Met Val Asp Pro Glu Ala Gln Ala Pro Xaa Lys Gln Pro Pro Arg 
305                 310                 315                 320 


Ser Ser Pro Asn Xaa Val Lys Arg Pro Xaa Lys Lys Gly Arg Asp Arg 
                325                 330                 335     


Ala Gly Lys Gly Gln Lys Pro Arg Gly Lys Glu Gln Leu Ala Lys Arg 
            340                 345                 350         


Lys Xaa Phe Ser Leu Val Lys Glu Lys Lys Ala Ala Arg Xaa Leu Ser 
        355                 360                 365             


Ala Ile Leu Leu Ala Phe Ile Leu Xaa Trp Xaa Pro Tyr Asn Ile Met 
    370                 375                 380                 


Val Leu Val Ser Xaa Phe Cys Lys Asp Cys Val Pro Glu Xaa Leu Trp 
385                 390                 395                 400 


Glu Leu Gly Tyr Trp Leu Cys Tyr Val Asn Ser Xaa Ile Asn Pro Met 
                405                 410                 415     


Cys Tyr Ala Leu Cys Asn Lys Ala Phe Arg Asp Xaa Phe Arg Leu Leu 
            420                 425                 430         


Leu Leu Cys Arg Trp Asp Lys Arg Arg Trp Arg Lys Ile Pro Lys Arg 
        435                 440                 445             


Pro Gly Ser Val His Arg Xaa Pro Ser Arg Gln Cys 
    450                 455                 460 


<210> 6136
<211> 466
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<400> 6136
Met Asn Asn Ser Xaa Asn Ser Ser Asn Asn Ser Leu Ala Leu Xaa Ser 
1               5                   10                  15      


Pro Tyr Lys Xaa Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Xaa Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Xaa Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Xaa Leu Tyr Xaa Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Xaa Lys Pro 
        115                 120                 125             


Leu Xaa Tyr Pro Val Lys Arg Xaa Xaa Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Xaa Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Xaa Phe Gly Xaa Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Xaa Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Xaa Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Xaa Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Xaa Gln Asp 
    290                 295                 300                 


Glu Asn Xaa Val Ser Xaa Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Xaa Cys Ile Arg Ile Gly Xaa Lys Xaa Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Xaa Pro Xaa Asn Xaa Xaa Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Xaa Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Xaa Arg Xaa Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Xaa Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Xaa Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Xaa Val Trp Xaa Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Xaa Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Xaa Phe Lys 
        435                 440                 445             


Lys Xaa Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Xaa Arg 
465     


<210> 6137
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<400> 6137
Met Xaa Leu His Asn Asn Ser Xaa Xaa Ser Pro Leu Phe Pro Asn Ile 
1               5                   10                  15      


Ser Ser Ser Trp Ile His Ser Pro Ser Asp Ala Gly Leu Pro Pro Gly 
            20                  25                  30          


Xaa Val Xaa His Phe Gly Ser Tyr Asn Val Ser Arg Ala Ala Gly Asn 
        35                  40                  45              


Phe Ser Ser Pro Asp Gly Xaa Xaa Asp Asp Pro Leu Gly Gly His Xaa 
    50                  55                  60                  


Val Trp Gln Val Val Phe Ile Ala Phe Leu Xaa Gly Ile Leu Ala Leu 
65                  70                  75                  80  


Val Xaa Ile Ile Gly Asn Ile Leu Val Ile Val Ser Phe Lys Val Asn 
                85                  90                  95      


Lys Gln Leu Lys Xaa Val Asn Asn Tyr Phe Leu Leu Ser Leu 
            100                 105                 110 


<210> 6138
<211> 590
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(554)
<223> Selenocysteine

<400> 6138
Met Xaa Leu His Asn Asn Ser Xaa Xaa Ser Pro Leu Phe Pro Asn Ile 
1               5                   10                  15      


Ser Ser Ser Trp Ile His Ser Pro Ser Asp Ala Gly Leu Pro Pro Gly 
            20                  25                  30          


Xaa Val Xaa His Phe Gly Ser Tyr Asn Val Ser Arg Ala Ala Gly Asn 
        35                  40                  45              


Phe Ser Ser Pro Asp Gly Xaa Xaa Asp Asp Pro Leu Gly Gly His Xaa 
    50                  55                  60                  


Val Trp Gln Val Val Phe Ile Ala Phe Leu Xaa Gly Ile Leu Ala Leu 
65                  70                  75                  80  


Val Xaa Ile Ile Gly Asn Ile Leu Val Ile Val Ser Phe Lys Val Asn 
                85                  90                  95      


Lys Gln Leu Lys Xaa Val Asn Asn Tyr Phe Leu Leu Ser Leu Ala Cys 
            100                 105                 110         


Ala Asp Leu Ile Ile Gly Val Ile Ser Met Asn Leu Phe Xaa Xaa Tyr 
        115                 120                 125             


Ile Ile Met Asn Arg Trp Ala Leu Gly Asn Leu Ala Cys Asp Leu Trp 
    130                 135                 140                 


Leu Ala Ile Asp Tyr Val Ala Ser Asn Ala Ser Val Met Asn Leu Leu 
145                 150                 155                 160 


Val Ile Ser Phe Asp Arg Tyr Phe Ser Ile Xaa Arg Pro Leu Xaa Tyr 
                165                 170                 175     


Arg Ala Lys Arg Xaa Xaa Lys Arg Ala Gly Val Met Ile Gly Leu Ala 
            180                 185                 190         


Trp Val Ile Ser Phe Val Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln 
        195                 200                 205             


Tyr Phe Val Gly Lys Arg Xaa Val Pro Pro Gly Glu Cys Phe Ile Gln 
    210                 215                 220                 


Phe Leu Ser Glu Pro Xaa Ile Xaa Phe Gly Xaa Ala Ile Ala Ala Phe 
225                 230                 235                 240 


Tyr Met Pro Val Xaa Ile Met Xaa Ile Leu Tyr Trp Arg Ile Tyr Lys 
                245                 250                 255     


Glu Xaa Glu Lys Arg Xaa Lys Glu Leu Ala Gly Leu Gln Ala Ser Gly 
            260                 265                 270         


Xaa Glu Ala Glu Xaa Glu Asn Phe Val His Pro Xaa Gly Ser Ser Arg 
        275                 280                 285             


Ser Cys Ser Ser Tyr Glu Leu Gln Gln Gln Ser Met Lys Arg Ser Asn 
    290                 295                 300                 


Arg Arg Lys Tyr Gly Arg Cys His Phe Trp Phe Xaa Xaa Lys Ser Trp 
305                 310                 315                 320 


Lys Pro Ser Ser Glu Gln Met Asp Gln Asp His Ser Ser Ser Asp Ser 
                325                 330                 335     


Trp Asn Asn Asn Asp Ala Ala Ala Ser Leu Glu Asn Ser Ala Ser Ser 
            340                 345                 350         


Asp Glu Glu Asp Ile Gly Ser Glu Xaa Arg Ala Ile Tyr Ser Ile Val 
        355                 360                 365             


Leu Lys Leu Pro Gly His Ser Xaa Ile Leu Asn Ser Xaa Lys Leu Pro 
    370                 375                 380                 


Ser Ser Asp Asn Leu Gln Val Pro Glu Glu Glu Leu Gly Met Val Asp 
385                 390                 395                 400 


Leu Glu Arg Lys Ala Asp Lys Leu Gln Ala Gln Lys Ser Val Asp Asp 
                405                 410                 415     


Gly Gly Ser Phe Pro Lys Ser Phe Ser Lys Leu Pro Ile Gln Leu Glu 
            420                 425                 430         


Ser Ala Val Asp Xaa Ala Lys Xaa Ser Asp Val Asn Ser Ser Val Gly 
        435                 440                 445             


Lys Ser Xaa Ala Xaa Leu Pro Leu Ser Phe Lys Glu Ala Xaa Leu Ala 
    450                 455                 460                 


Lys Arg Phe Ala Leu Lys Xaa Arg Ser Gln Ile Xaa Lys Arg Lys Arg 
465                 470                 475                 480 


Met Ser Leu Val Lys Glu Lys Lys Ala Ala Gln Xaa Leu Ser Ala Ile 
                485                 490                 495     


Leu Leu Ala Phe Ile Ile Xaa Trp Xaa Pro Tyr Asn Ile Met Val Leu 
            500                 505                 510         


Val Asn Xaa Phe Cys Asp Ser Cys Ile Pro Lys Xaa Phe Trp Asn Leu 
        515                 520                 525             


Gly Tyr Trp Leu Cys Tyr Ile Asn Ser Xaa Val Asn Pro Val Cys Tyr 
    530                 535                 540                 


Ala Leu Cys Asn Lys Xaa Phe Arg Xaa Xaa Phe Lys Met Leu Leu Leu 
545                 550                 555                 560 


Cys Gln Cys Asp Lys Lys Lys Arg Arg Lys Gln Gln Tyr Gln Gln Arg 
                565                 570                 575     


Gln Ser Val Ile Phe His Lys Arg Ala Pro Glu Gln Ala Leu 
            580                 585                 590 


<210> 6139
<211> 479
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<400> 6139
Met Ala Asn Phe Xaa Pro Val Asn Gly Ser Ser Gly Asn Gln Ser Val 
1               5                   10                  15      


Arg Leu Val Xaa Ser Ser Ser His Asn Arg Tyr Glu Xaa Val Glu Met 
            20                  25                  30          


Val Phe Ile Ala Xaa Val Xaa Gly Ser Leu Ser Leu Val Xaa Val Val 
        35                  40                  45              


Gly Asn Ile Leu Val Met Leu Ser Ile Lys Val Asn Arg Gln Leu Gln 
    50                  55                  60                  


Xaa Val Asn Asn Tyr Phe Leu Phe Ser Leu Ala Cys Ala Asp Leu Ile 
65                  70                  75                  80  


Ile Gly Ala Phe Ser Met Asn Leu Tyr Xaa Val Tyr Ile Ile Lys Gly 
                85                  90                  95      


Tyr Trp Pro Leu Gly Ala Val Val Cys Asp Leu Trp Leu Ala Leu Asp 
            100                 105                 110         


Tyr Val Val Ser Asn Ala Ser Val Met Asn Leu Leu Ile Ile Ser Phe 
        115                 120                 125             


Asp Arg Tyr Phe Cys Val Xaa Lys Pro Leu Xaa Tyr Pro Ala Arg Arg 
    130                 135                 140                 


Xaa Xaa Lys Met Ala Gly Leu Met Ile Ala Ala Ala Trp Val Leu Ser 
145                 150                 155                 160 


Phe Val Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln Phe Val Val Gly 
                165                 170                 175     


Lys Arg Xaa Val Pro Asp Asn Gln Cys Phe Ile Gln Phe Leu Ser Asn 
            180                 185                 190         


Pro Ala Val Xaa Phe Gly Xaa Ala Ile Ala Ala Phe Tyr Leu Pro Val 
        195                 200                 205             


Val Ile Met Xaa Val Leu Tyr Ile His Ile Ser Leu Ala Ser Arg Ser 
    210                 215                 220                 


Arg Val His Lys His Arg Pro Glu Gly Pro Lys Glu Lys Lys Ala Lys 
225                 230                 235                 240 


Xaa Leu Ala Phe Leu Lys Ser Pro Leu Met Lys Gln Ser Val Lys Lys 
                245                 250                 255     


Pro Pro Pro Gly Glu Ala Ala Arg Glu Glu Leu Arg Asn Gly Lys Leu 
            260                 265                 270         


Glu Glu Ala Pro Pro Pro Ala Leu Pro Pro Pro Pro Arg Pro Val Ala 
        275                 280                 285             


Asp Lys Asp Xaa Ser Asn Glu Ser Ser Ser Gly Ser Ala Xaa Gln Asn 
    290                 295                 300                 


Xaa Lys Glu Arg Pro Ala Xaa Glu Leu Ser Xaa Xaa Glu Ala Xaa Xaa 
305                 310                 315                 320 


Pro Ala Met Pro Ala Pro Pro Leu Gln Pro Arg Ala Leu Asn Pro Ala 
                325                 330                 335     


Ser Arg Trp Ser Lys Ile Gln Ile Val Xaa Lys Gln Xaa Gly Asn Glu 
            340                 345                 350         


Cys Val Xaa Ala Ile Glu Ile Val Pro Ala Xaa Pro Ala Gly Met Arg 
        355                 360                 365             


Pro Ala Ala Asn Val Ala Arg Lys Phe Ala Ser Ile Ala Arg Asn Gln 
    370                 375                 380                 


Val Arg Lys Lys Arg Gln Met Ala Ala Arg Glu Arg Lys Val Xaa Arg 
385                 390                 395                 400 


Xaa Ile Phe Ala Ile Leu Leu Ala Phe Ile Leu Xaa Trp Xaa Pro Tyr 
                405                 410                 415     


Asn Val Met Val Leu Val Asn Xaa Phe Cys Gln Ser Cys Ile Pro Asp 
            420                 425                 430         


Xaa Val Trp Ser Ile Gly Tyr Trp Leu Cys Tyr Val Asn Ser Xaa Ile 
        435                 440                 445             


Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Xaa Phe Lys Lys Xaa Phe 
    450                 455                 460                 


Arg His Leu Leu Leu Cys Gln Tyr Arg Asn Ile Gly Xaa Ala Arg 
465                 470                 475                 


<210> 6140
<211> 22
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<400> 6140
Met Glu Gly Asp Ser Tyr His Asn Ala Xaa Xaa Val Asn Gly Xaa Pro 
1               5                   10                  15      


Val Asn His Gln Pro Leu 
            20          


<210> 6141
<211> 532
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<400> 6141
Met Glu Gly Asp Ser Tyr His Asn Ala Xaa Xaa Val Asn Gly Xaa Pro 
1               5                   10                  15      


Val Asn His Gln Pro Leu Glu Arg His Arg Leu Trp Glu Val Ile Xaa 
            20                  25                  30          


Ile Ala Ala Val Xaa Ala Val Val Ser Leu Ile Xaa Ile Val Gly Asn 
        35                  40                  45              


Val Leu Val Met Ile Ser Phe Lys Val Asn Ser Gln Leu Lys Xaa Val 
    50                  55                  60                  


Asn Asn Tyr Tyr Leu Leu Ser Leu Ala Cys Ala Asp Leu Ile Ile Gly 
65                  70                  75                  80  


Ile Phe Ser Met Asn Leu Tyr Xaa Xaa Tyr Ile Leu Met Gly Arg Trp 
                85                  90                  95      


Ala Leu Gly Ser Leu Ala Cys Asp Leu Trp Leu Ala Leu Asp Tyr Val 
            100                 105                 110         


Ala Ser Asn Ala Ser Val Met Asn Leu Leu Val Ile Ser Phe Asp Arg 
        115                 120                 125             


Tyr Phe Ser Ile Xaa Arg Pro Leu Xaa Tyr Arg Ala Lys Arg Xaa Pro 
    130                 135                 140                 


Lys Arg Ala Gly Ile Met Ile Gly Leu Ala Trp Leu Ile Ser Phe Ile 
145                 150                 155                 160 


Leu Trp Ala Pro Ala Ile Leu Cys Trp Gln Tyr Leu Val Gly Lys Arg 
                165                 170                 175     


Xaa Val Pro Leu Asp Glu Cys Gln Ile Gln Phe Leu Ser Glu Pro Xaa 
            180                 185                 190         


Ile Xaa Phe Gly Xaa Ala Ile Ala Ala Phe Tyr Ile Pro Val Ser Val 
        195                 200                 205             


Met Xaa Ile Leu Tyr Cys Arg Ile Tyr Arg Glu Xaa Glu Lys Arg Xaa 
    210                 215                 220                 


Lys Asp Leu Ala Asp Leu Gln Gly Ser Asp Ser Val Xaa Lys Ala Glu 
225                 230                 235                 240 


Lys Arg Lys Pro Ala His Arg Ala Leu Phe Arg Ser Cys Leu Arg Cys 
                245                 250                 255     


Pro Arg Pro Xaa Leu Ala Gln Arg Glu Arg Asn Gln Ala Ser Trp Ser 
            260                 265                 270         


Ser Ser Arg Arg Ser Xaa Ser Xaa Xaa Gly Lys Pro Ser Gln Ala Xaa 
        275                 280                 285             


Gly Pro Ser Ala Asn Trp Ala Lys Ala Glu Gln Leu Xaa Xaa Cys Ser 
    290                 295                 300                 


Ser Tyr Pro Ser Ser Glu Asp Glu Asp Lys Pro Ala Xaa Asp Pro Val 
305                 310                 315                 320 


Leu Gln Val Val Tyr Lys Ser Gln Gly Lys Glu Ser Pro Gly Glu Glu 
                325                 330                 335     


Phe Ser Ala Glu Glu Xaa Glu Glu Xaa Phe Val Lys Ala Glu Xaa Glu 
            340                 345                 350         


Lys Ser Asp Tyr Asp Xaa Pro Asn Tyr Leu Leu Ser Pro Ala Ala Ala 
        355                 360                 365             


His Arg Pro Lys Ser Gln Lys Cys Val Ala Tyr Lys Phe Arg Leu Val 
    370                 375                 380                 


Val Lys Ala Asp Gly Asn Gln Glu Xaa Asn Asn Gly Cys His Lys Val 
385                 390                 395                 400 


Lys Ile Met Pro Cys Pro Phe Pro Val Ala Lys Glu Pro Ser Xaa Lys 
                405                 410                 415     


Gly Leu Asn Pro Asn Pro Ser His Gln Met Xaa Lys Arg Lys Arg Val 
            420                 425                 430         


Val Leu Val Lys Glu Arg Lys Ala Ala Gln Xaa Leu Ser Ala Ile Leu 
        435                 440                 445             


Leu Ala Phe Ile Ile Xaa Trp Xaa Pro Tyr Asn Ile Met Val Leu Val 
    450                 455                 460                 


Ser Xaa Phe Cys Asp Lys Cys Val Pro Val Xaa Leu Trp His Leu Gly 
465                 470                 475                 480 


Tyr Trp Leu Cys Tyr Val Asn Ser Xaa Val Asn Pro Ile Cys Tyr Ala 
                485                 490                 495     


Leu Cys Asn Arg Xaa Phe Arg Lys Xaa Phe Lys Met Leu Leu Leu Cys 
            500                 505                 510         


Arg Trp Lys Lys Lys Lys Val Glu Glu Lys Leu Tyr Trp Gln Gly Asn 
        515                 520                 525             


Ser Lys Leu Pro 
    530         


<210> 6142
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(72)
<223> Selenocysteine

<400> 6142
Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Xaa Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Xaa Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Xaa Xaa Asn Val Arg Leu Lys Gln Cys Arg 
65                  70                  75                  80  


Trp 
    


<210> 6143
<211> 482
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<400> 6143
Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Xaa Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Xaa Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Xaa Xaa Asn Val Arg Leu Lys Gln Gly Asp 
65                  70                  75                  80  


Met Val Asp Leu Pro Arg Pro Ser Cys Val Xaa Leu Gly Val Pro Leu 
                85                  90                  95      


Phe Ser His Leu Gln Asn Glu Gln Trp Val Asp Tyr Asn Leu Lys Trp 
            100                 105                 110         


Asn Pro Asp Asp Tyr Gly Gly Val Lys Lys Ile His Ile Pro Ser Glu 
        115                 120                 125             


Lys Ile Trp Arg Pro Asp Leu Val Leu Tyr Asn Asn Ala Asp Gly Asp 
    130                 135                 140                 


Phe Ala Ile Val Lys Phe Xaa Lys Val Leu Leu Gln Tyr Xaa Gly His 
145                 150                 155                 160 


Ile Xaa Trp Xaa Pro Pro Ala Ile Phe Lys Ser Tyr Cys Glu Ile Ile 
                165                 170                 175     


Val Xaa His Phe Pro Phe Asp Glu Gln Asn Cys Ser Met Lys Leu Gly 
            180                 185                 190         


Xaa Trp Xaa Tyr Asp Gly Ser Val Val Ala Ile Asn Pro Glu Ser Asp 
        195                 200                 205             


Gln Pro Asp Leu Ser Asn Phe Met Glu Ser Gly Glu Trp Val Ile Lys 
    210                 215                 220                 


Glu Ser Arg Gly Trp Lys His Ser Val Xaa Tyr Ser Cys Cys Pro Asp 
225                 230                 235                 240 


Xaa Pro Tyr Leu Asp Ile Xaa Tyr His Phe Val Met Gln Arg Leu Pro 
                245                 250                 255     


Leu Tyr Phe Ile Val Asn Val Ile Ile Pro Cys Leu Leu Phe Ser Phe 
            260                 265                 270         


Leu Xaa Gly Leu Val Phe Tyr Leu Pro Xaa Asp Ser Gly Glu Lys Met 
        275                 280                 285             


Xaa Leu Ser Ile Ser Val Leu Leu Ser Leu Xaa Val Phe Leu Leu Val 
    290                 295                 300                 


Ile Val Glu Leu Ile Pro Ser Xaa Ser Ser Ala Val Pro Leu Ile Gly 
305                 310                 315                 320 


Lys Tyr Met Leu Phe Xaa Met Val Phe Val Ile Ala Ser Ile Ile Ile 
                325                 330                 335     


Xaa Val Ile Val Ile Asn Xaa His His Arg Ser Pro Ser Xaa His Val 
            340                 345                 350         


Met Pro Asn Trp Val Arg Lys Val Phe Ile Asp Xaa Ile Pro Asn Ile 
        355                 360                 365             


Met Phe Phe Ser Xaa Met Lys Arg Pro Ser Arg Glu Lys Gln Asp Lys 
    370                 375                 380                 


Lys Ile Phe Xaa Glu Asp Ile Asp Ile Ser Asp Ile Ser Gly Lys Pro 
385                 390                 395                 400 


Gly Pro Pro Pro Met Gly Phe His Ser Pro Leu Ile Lys His Pro Glu 
                405                 410                 415     


Val Lys Ser Ala Ile Glu Gly Ile Lys Tyr Ile Ala Glu Xaa Met Lys 
            420                 425                 430         


Ser Asp Gln Glu Ser Asn Asn Ala Ala Ala Glu Trp Lys Tyr Val Ala 
        435                 440                 445             


Met Val Met Asp His Ile Leu Leu Gly Val Phe Met Leu Val Cys Ile 
    450                 455                 460                 


Ile Gly Xaa Leu Ala Val Phe Ala Gly Arg Leu Ile Glu Leu Asn Gln 
465                 470                 475                 480 


Gln Gly 
        


<210> 6144
<211> 375
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<400> 6144
Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Xaa Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Xaa Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Xaa Xaa Asn Val Arg Leu Lys Gln Asn Cys 
65                  70                  75                  80  


Ser Met Lys Leu Gly Xaa Trp Xaa Tyr Asp Gly Ser Val Val Ala Ile 
                85                  90                  95      


Asn Pro Glu Ser Asp Gln Pro Asp Leu Ser Asn Phe Met Glu Ser Gly 
            100                 105                 110         


Glu Trp Val Ile Lys Glu Ser Arg Gly Trp Lys His Ser Val Xaa Tyr 
        115                 120                 125             


Ser Cys Cys Pro Asp Xaa Pro Tyr Leu Asp Ile Xaa Tyr His Phe Val 
    130                 135                 140                 


Met Gln Arg Leu Pro Leu Tyr Phe Ile Val Asn Val Ile Ile Pro Cys 
145                 150                 155                 160 


Leu Leu Phe Ser Phe Leu Xaa Gly Leu Val Phe Tyr Leu Pro Xaa Asp 
                165                 170                 175     


Ser Gly Glu Lys Met Xaa Leu Ser Ile Ser Val Leu Leu Ser Leu Xaa 
            180                 185                 190         


Val Phe Leu Leu Val Ile Val Glu Leu Ile Pro Ser Xaa Ser Ser Ala 
        195                 200                 205             


Val Pro Leu Ile Gly Lys Tyr Met Leu Phe Xaa Met Val Phe Val Ile 
    210                 215                 220                 


Ala Ser Ile Ile Ile Xaa Val Ile Val Ile Asn Xaa His His Arg Ser 
225                 230                 235                 240 


Pro Ser Xaa His Val Met Pro Asn Trp Val Arg Lys Val Phe Ile Asp 
                245                 250                 255     


Xaa Ile Pro Asn Ile Met Phe Phe Ser Xaa Met Lys Arg Pro Ser Arg 
            260                 265                 270         


Glu Lys Gln Asp Lys Lys Ile Phe Xaa Glu Asp Ile Asp Ile Ser Asp 
        275                 280                 285             


Ile Ser Gly Lys Pro Gly Pro Pro Pro Met Gly Phe His Ser Pro Leu 
    290                 295                 300                 


Ile Lys His Pro Glu Val Lys Ser Ala Ile Glu Gly Ile Lys Tyr Ile 
305                 310                 315                 320 


Ala Glu Xaa Met Lys Ser Asp Gln Glu Ser Asn Asn Ala Ala Ala Glu 
                325                 330                 335     


Trp Lys Tyr Val Ala Met Val Met Asp His Ile Leu Leu Gly Val Phe 
            340                 345                 350         


Met Leu Val Cys Ile Ile Gly Xaa Leu Ala Val Phe Ala Gly Arg Leu 
        355                 360                 365             


Ile Glu Leu Asn Gln Gln Gly 
    370                 375 


<210> 6145
<211> 269
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<400> 6145
Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Xaa Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Xaa Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Xaa Xaa Asn Val Arg Leu Lys Gln Gln Trp 
65                  70                  75                  80  


Val Asp Tyr Asn Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys 
                85                  90                  95      


Lys Ile His Ile Pro Ser Glu Lys Ile Trp Arg Pro Asp Leu Val Leu 
            100                 105                 110         


Tyr Asn Asn Ala Asp Gly Asp Phe Ala Ile Val Lys Phe Xaa Lys Val 
        115                 120                 125             


Leu Leu Gln Tyr Xaa Gly His Ile Xaa Trp Xaa Pro Pro Ala Ile Phe 
    130                 135                 140                 


Lys Ser Tyr Cys Glu Ile Ile Val Xaa His Phe Pro Phe Asp Glu Gln 
145                 150                 155                 160 


Asn Cys Ser Met Lys Leu Gly Xaa Trp Xaa Tyr Asp Gly Ser Val Val 
                165                 170                 175     


Ala Ile Asn Pro Glu Ser Asp Gln Pro Asp Leu Ser Asn Phe Met Glu 
            180                 185                 190         


Ser Gly Glu Trp Val Ile Lys Glu Ser Arg Gly Trp Lys His Ser Val 
        195                 200                 205             


Xaa Tyr Ser Cys Cys Pro Asp Xaa Pro Tyr Leu Asp Ile Xaa Tyr His 
    210                 215                 220                 


Phe Val Met Gln Arg Leu Pro Leu Tyr Phe Ile Val Asn Val Ile Ile 
225                 230                 235                 240 


Pro Cys Leu Leu Phe Ser Phe Leu Xaa Gly Leu Val Phe Tyr Leu Pro 
                245                 250                 255     


Xaa Asp Ser Gly Gly Cys Gly Cys His Asp Cys Cys Cys 
            260                 265                 


<210> 6146
<211> 377
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<400> 6146
Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Xaa Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Xaa Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Xaa Xaa Asn Val Arg Leu Lys Gln Gln Trp 
65                  70                  75                  80  


Val Asp Tyr Asn Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys 
                85                  90                  95      


Lys Ile His Ile Pro Ser Glu Lys Ile Trp Arg Pro Asp Leu Val Leu 
            100                 105                 110         


Tyr Asn Asn Ala Asp Gly Asp Phe Ala Ile Val Lys Phe Xaa Lys Val 
        115                 120                 125             


Leu Leu Gln Tyr Xaa Gly His Ile Xaa Trp Xaa Pro Pro Ala Ile Phe 
    130                 135                 140                 


Lys Ser Tyr Cys Glu Ile Ile Val Xaa His Phe Pro Phe Asp Glu Gln 
145                 150                 155                 160 


Asn Cys Ser Met Lys Leu Gly Xaa Trp Xaa Tyr Asp Gly Ser Val Val 
                165                 170                 175     


Ala Ile Asn Pro Glu Ser Asp Gln Pro Asp Leu Ser Asn Phe Met Glu 
            180                 185                 190         


Ser Gly Glu Trp Val Ile Lys Glu Ser Arg Gly Trp Lys His Ser Val 
        195                 200                 205             


Xaa Tyr Ser Cys Cys Pro Asp Xaa Pro Tyr Leu Asp Ile Xaa Tyr His 
    210                 215                 220                 


Phe Val Met Gln Arg Leu Pro Leu Tyr Phe Ile Val Asn Val Ile Ile 
225                 230                 235                 240 


Pro Cys Leu Leu Phe Ser Phe Leu Xaa Gly Leu Val Phe Tyr Leu Pro 
                245                 250                 255     


Xaa Asp Ser Gly Glu Lys Met Xaa Leu Ser Ile Ser Val Leu Leu Ser 
            260                 265                 270         


Leu Xaa Val Phe Leu Leu Val Ile Val Glu Leu Ile Pro Ser Xaa Ser 
        275                 280                 285             


Ser Ala Val Pro Leu Ile Gly Lys Tyr Met Leu Phe Xaa Met Val Phe 
    290                 295                 300                 


Val Ile Ala Ser Ile Ile Ile Xaa Val Ile Val Ile Asn Xaa His His 
305                 310                 315                 320 


Arg Ser Pro Ser Xaa His Val Met Pro Asn Trp Val Arg Lys Ala Ala 
                325                 330                 335     


Ala Glu Trp Lys Tyr Val Ala Met Val Met Asp His Ile Leu Leu Gly 
            340                 345                 350         


Val Phe Met Leu Val Cys Ile Ile Gly Xaa Leu Ala Val Phe Ala Gly 
        355                 360                 365             


Arg Leu Ile Glu Leu Asn Gln Gln Gly 
    370                 375         


<210> 6147
<211> 457
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<400> 6147
Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Xaa Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Xaa Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Xaa Xaa Asn Val Arg Leu Lys Gln Gln Trp 
65                  70                  75                  80  


Val Asp Tyr Asn Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys 
                85                  90                  95      


Lys Ile His Ile Pro Ser Glu Lys Ile Trp Arg Pro Asp Leu Val Leu 
            100                 105                 110         


Tyr Asn Asn Ala Asp Gly Asp Phe Ala Ile Val Lys Phe Xaa Lys Val 
        115                 120                 125             


Leu Leu Gln Tyr Xaa Gly His Ile Xaa Trp Xaa Pro Pro Ala Ile Phe 
    130                 135                 140                 


Lys Ser Tyr Cys Glu Ile Ile Val Xaa His Phe Pro Phe Asp Glu Gln 
145                 150                 155                 160 


Asn Cys Ser Met Lys Leu Gly Xaa Trp Xaa Tyr Asp Gly Ser Val Val 
                165                 170                 175     


Ala Ile Asn Pro Glu Ser Asp Gln Pro Asp Leu Ser Asn Phe Met Glu 
            180                 185                 190         


Ser Gly Glu Trp Val Ile Lys Glu Ser Arg Gly Trp Lys His Ser Val 
        195                 200                 205             


Xaa Tyr Ser Cys Cys Pro Asp Xaa Pro Tyr Leu Asp Ile Xaa Tyr His 
    210                 215                 220                 


Phe Val Met Gln Arg Leu Pro Leu Tyr Phe Ile Val Asn Val Ile Ile 
225                 230                 235                 240 


Pro Cys Leu Leu Phe Ser Phe Leu Xaa Gly Leu Val Phe Tyr Leu Pro 
                245                 250                 255     


Xaa Asp Ser Gly Glu Lys Met Xaa Leu Ser Ile Ser Val Leu Leu Ser 
            260                 265                 270         


Leu Xaa Val Phe Leu Leu Val Ile Val Glu Leu Ile Pro Ser Xaa Ser 
        275                 280                 285             


Ser Ala Val Pro Leu Ile Gly Lys Tyr Met Leu Phe Xaa Met Val Phe 
    290                 295                 300                 


Val Ile Ala Ser Ile Ile Ile Xaa Val Ile Val Ile Asn Xaa His His 
305                 310                 315                 320 


Arg Ser Pro Ser Xaa His Val Met Pro Asn Trp Val Arg Lys Val Phe 
                325                 330                 335     


Ile Asp Xaa Ile Pro Asn Ile Met Phe Phe Ser Xaa Met Lys Arg Pro 
            340                 345                 350         


Ser Arg Glu Lys Gln Asp Lys Lys Ile Phe Xaa Glu Asp Ile Asp Ile 
        355                 360                 365             


Ser Asp Ile Ser Gly Lys Pro Gly Pro Pro Pro Met Gly Phe His Ser 
    370                 375                 380                 


Pro Leu Ile Lys His Pro Glu Val Lys Ser Ala Ile Glu Gly Ile Lys 
385                 390                 395                 400 


Tyr Ile Ala Glu Xaa Met Lys Ser Asp Gln Glu Ser Asn Asn Ala Ala 
                405                 410                 415     


Ala Glu Trp Lys Tyr Val Ala Met Val Met Asp His Ile Leu Leu Gly 
            420                 425                 430         


Val Phe Met Leu Val Cys Ile Ile Gly Xaa Leu Ala Val Phe Ala Gly 
        435                 440                 445             


Arg Leu Ile Glu Leu Asn Gln Gln Gly 
    450                 455         


<210> 6148
<211> 470
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<400> 6148
Met Trp Xaa Lys Val Lys Gly Arg Asn Ser Leu Xaa Gly Leu Gly Leu 
1               5                   10                  15      


Asp Leu Ser Lys Xaa Val Ser Pro His Trp Ala Ala Gly Leu Val Leu 
            20                  25                  30          


Gly Ser Glu His Glu Xaa Arg Leu Val Ala Lys Leu Phe Lys Asp Tyr 
        35                  40                  45              


Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val Val Glu Val 
    50                  55                  60                  


Xaa Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp Glu Val Asn 
65                  70                  75                  80  


Gln Ile Val Xaa Xaa Asn Val Arg Leu Lys Gln Gln Trp Val Asp Tyr 
                85                  90                  95      


Asn Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys Lys Ile His 
            100                 105                 110         


Ile Pro Ser Glu Lys Ile Trp Arg Pro Asp Leu Val Leu Tyr Asn Asn 
        115                 120                 125             


Ala Asp Gly Asp Phe Ala Ile Val Lys Phe Xaa Lys Val Leu Leu Gln 
    130                 135                 140                 


Tyr Xaa Gly His Ile Xaa Trp Xaa Pro Pro Ala Ile Phe Lys Ser Tyr 
145                 150                 155                 160 


Cys Glu Ile Ile Val Xaa His Phe Pro Phe Asp Glu Gln Asn Cys Ser 
                165                 170                 175     


Met Lys Leu Gly Xaa Trp Xaa Tyr Asp Gly Ser Val Val Ala Ile Asn 
            180                 185                 190         


Pro Glu Ser Asp Gln Pro Asp Leu Ser Asn Phe Met Glu Ser Gly Glu 
        195                 200                 205             


Trp Val Ile Lys Glu Ser Arg Gly Trp Lys His Ser Val Xaa Tyr Ser 
    210                 215                 220                 


Cys Cys Pro Asp Xaa Pro Tyr Leu Asp Ile Xaa Tyr His Phe Val Met 
225                 230                 235                 240 


Gln Arg Leu Pro Leu Tyr Phe Ile Val Asn Val Ile Ile Pro Cys Leu 
                245                 250                 255     


Leu Phe Ser Phe Leu Xaa Gly Leu Val Phe Tyr Leu Pro Xaa Asp Ser 
            260                 265                 270         


Gly Glu Lys Met Xaa Leu Ser Ile Ser Val Leu Leu Ser Leu Xaa Val 
        275                 280                 285             


Phe Leu Leu Val Ile Val Glu Leu Ile Pro Ser Xaa Ser Ser Ala Val 
    290                 295                 300                 


Pro Leu Ile Gly Lys Tyr Met Leu Phe Xaa Met Val Phe Val Ile Ala 
305                 310                 315                 320 


Ser Ile Ile Ile Xaa Val Ile Val Ile Asn Xaa His His Arg Ser Pro 
                325                 330                 335     


Ser Xaa His Val Met Pro Asn Trp Val Arg Lys Val Phe Ile Asp Xaa 
            340                 345                 350         


Ile Pro Asn Ile Met Phe Phe Ser Xaa Met Lys Arg Pro Ser Arg Glu 
        355                 360                 365             


Lys Gln Asp Lys Lys Ile Phe Xaa Glu Asp Ile Asp Ile Ser Asp Ile 
    370                 375                 380                 


Ser Gly Lys Pro Gly Pro Pro Pro Met Gly Phe His Ser Pro Leu Ile 
385                 390                 395                 400 


Lys His Pro Glu Val Lys Ser Ala Ile Glu Gly Ile Lys Tyr Ile Ala 
                405                 410                 415     


Glu Xaa Met Lys Ser Asp Gln Glu Ser Asn Asn Ala Ala Ala Glu Trp 
            420                 425                 430         


Lys Tyr Val Ala Met Val Met Asp His Ile Leu Leu Gly Val Phe Met 
        435                 440                 445             


Leu Val Cys Ile Ile Gly Xaa Leu Ala Val Phe Ala Gly Arg Leu Ile 
    450                 455                 460                 


Glu Leu Asn Gln Gln Gly 
465                 470 


<210> 6149
<211> 123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(120)
<223> Selenocysteine

<400> 6149
Met Cys Gly Arg Ala Ala Leu Gln Pro Ala Trp Arg Xaa Ser Trp Arg 
1               5                   10                  15      


Xaa Trp Ser Gly Ala Cys Trp Ala Cys Arg Arg Gly Gly Ala Cys Ser 
            20                  25                  30          


Pro Xaa Ala Ala Ala Pro Ser Pro Xaa Pro Xaa Ser Pro Ser Arg Cys 
        35                  40                  45              


Cys Cys Ala Ala Ala Pro Pro Pro Xaa Cys Ala Xaa Cys Cys Cys Pro 
    50                  55                  60                  


Ala Cys Ser Ser Arg Cys Leu Arg Arg Ser Pro Ser Xaa Cys Leu Pro 
65                  70                  75                  80  


Xaa Gln Ala Arg Arg Cys Arg Trp Ala Ser Pro Cys Cys Trp Arg Ser 
                85                  90                  95      


Pro Ser Ser Ser Cys Cys Trp Pro Arg Ala Cys His Arg Pro Arg Ala 
            100                 105                 110         


Cys Arg Ser Ser Gly Ser Xaa Xaa Trp Pro Leu 
        115                 120             


<210> 6150
<211> 450
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<400> 6150
Met Gly Leu Arg Ser His His Leu Ser Leu Gly Leu Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Ala Glu Cys Leu Gly Ala Glu Gly Arg Leu Ala Leu Lys 
            20                  25                  30          


Leu Phe Arg Asp Leu Phe Ala Asn Tyr Xaa Ser Ala Leu Arg Pro Val 
        35                  40                  45              


Ala Asp Xaa Asp Gln Xaa Leu Asn Val Xaa Leu Glu Val Xaa Leu Ser 
    50                  55                  60                  


Gln Ile Ile Asp Met Asp Glu Arg Asn Gln Val Leu Xaa Leu Tyr Leu 
65                  70                  75                  80  


Trp Ile Arg Gln Glu Trp Xaa Asp Ala Tyr Leu Arg Trp Asp Pro Asn 
                85                  90                  95      


Ala Tyr Gly Gly Leu Asp Ala Ile Arg Ile Pro Ser Ser Leu Val Trp 
            100                 105                 110         


Arg Pro Asp Ile Val Leu Tyr Asn Lys Ala Asp Ala Gln Pro Pro Gly 
        115                 120                 125             


Ser Ala Ser Xaa Asn Val Val Leu Arg His Asp Gly Ala Val Arg Trp 
    130                 135                 140                 


Asp Ala Pro Ala Ile Xaa Arg Ser Ser Cys Arg Val Asp Val Ala Ala 
145                 150                 155                 160 


Phe Pro Phe Asp Ala Gln His Cys Gly Leu Xaa Phe Gly Ser Trp Xaa 
                165                 170                 175     


His Gly Gly His Gln Leu Asp Val Arg Pro Arg Gly Ala Ala Ala Ser 
            180                 185                 190         


Leu Ala Asp Phe Val Glu Asn Val Glu Trp Arg Val Leu Gly Met Pro 
        195                 200                 205             


Ala Arg Arg Arg Val Leu Xaa Tyr Gly Cys Cys Ser Glu Pro Tyr Pro 
    210                 215                 220                 


Asp Val Xaa Phe Xaa Leu Leu Leu Arg Arg Arg Ala Ala Ala Tyr Val 
225                 230                 235                 240 


Cys Asn Leu Leu Leu Pro Cys Val Leu Ile Ser Leu Leu Ala Pro Leu 
                245                 250                 255     


Ala Phe His Leu Pro Ala Asp Ser Gly Glu Lys Val Ser Leu Gly Val 
            260                 265                 270         


Xaa Val Leu Leu Ala Leu Xaa Val Phe Gln Leu Leu Leu Ala Glu Ser 
        275                 280                 285             


Met Pro Pro Ala Glu Ser Val Pro Leu Ile Gly Lys Tyr Tyr Met Ala 
    290                 295                 300                 


Xaa Met Xaa Met Val Xaa Phe Ser Xaa Ala Leu Xaa Ile Leu Ile Met 
305                 310                 315                 320 


Asn Leu His Tyr Cys Gly Pro Ser Val Arg Pro Val Pro Ala Trp Ala 
                325                 330                 335     


Arg Ala Leu Leu Leu Gly His Leu Ala Arg Gly Leu Cys Val Arg Glu 
            340                 345                 350         


Arg Gly Glu Pro Cys Gly Gln Ser Arg Pro Pro Glu Leu Ser Pro Ser 
        355                 360                 365             


Pro Gln Ser Pro Glu Gly Gly Ala Gly Pro Pro Ala Gly Pro Cys His 
    370                 375                 380                 


Glu Pro Arg Cys Leu Cys Arg Gln Glu Ala Leu Leu His His Val Ala 
385                 390                 395                 400 


Xaa Ile Ala Asn Xaa Phe Arg Ser His Arg Ala Ala Gln Arg Cys His 
                405                 410                 415     


Glu Asp Trp Lys Arg Leu Ala Arg Val Met Asp Arg Phe Phe Leu Ala 
            420                 425                 430         


Ile Phe Phe Ser Met Ala Leu Val Met Ser Leu Leu Val Leu Val Gln 
        435                 440                 445             


Ala Leu 
    450 


<210> 6151
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<400> 6151
Met Gly Leu Arg Ser His His Leu Ser Leu Gly Leu Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Ala Glu Cys Leu Gly Ala Glu Gly Arg Leu Ala Leu Lys 
            20                  25                  30          


Leu Phe Arg Asp Leu Phe Ala Asn Tyr Xaa Ser Ala Leu Arg Pro Val 
        35                  40                  45              


Ala Asp Xaa Asp Gln Xaa Leu Asn Val Xaa Leu Glu Val Xaa Leu Ser 
    50                  55                  60                  


Gln Ile Ile Asp Met Val Arg Cys Gly Gly Gly Xaa Ala Val Glu Ser 
65                  70                  75                  80  


Tyr Leu Ser Gln Cys Gln Glu Met Lys Gly Met Asn Gly Xaa Arg Cys 
                85                  90                  95      


<210> 6152
<211> 507
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<400> 6152
Met Ala Gly Gly Glu Glu Ala Lys Arg Pro Pro Pro Arg Ala Pro Gly 
1               5                   10                  15      


Asp Pro Leu Ser Ser Pro Ser Pro Xaa Ala Leu Pro Gln Gly Gly Ser 
            20                  25                  30          


His Xaa Glu Xaa Glu Asp Arg Leu Phe Lys His Leu Phe Arg Gly Tyr 
        35                  40                  45              


Asn Arg Trp Ala Arg Pro Val Pro Asn Xaa Ser Asp Val Val Ile Val 
    50                  55                  60                  


Arg Phe Gly Leu Ser Ile Ala Gln Leu Ile Asp Val Asp Glu Lys Asn 
65                  70                  75                  80  


Gln Met Met Xaa Xaa Asn Val Trp Leu Lys Gln Glu Trp Ser Asp Tyr 
                85                  90                  95      


Lys Leu Arg Trp Asn Pro Xaa Asp Phe Gly Asn Ile Xaa Ser Leu Arg 
            100                 105                 110         


Val Pro Ser Glu Met Ile Trp Ile Pro Asp Ile Val Leu Tyr Asn Asn 
        115                 120                 125             


Ala Asp Gly Glu Phe Ala Val Xaa His Met Xaa Lys Ala His Leu Phe 
    130                 135                 140                 


Ser Xaa Gly Xaa Val His Trp Val Pro Pro Ala Ile Tyr Lys Ser Ser 
145                 150                 155                 160 


Cys Ser Ile Asp Val Xaa Phe Phe Pro Phe Asp Gln Gln Asn Cys Lys 
                165                 170                 175     


Met Lys Phe Gly Ser Trp Xaa Tyr Asp Lys Ala Lys Ile Asp Leu Glu 
            180                 185                 190         


Gln Met Glu Gln Xaa Val Asp Leu Lys Asp Tyr Trp Glu Ser Gly Glu 
        195                 200                 205             


Trp Ala Ile Val Asn Ala Xaa Gly Xaa Tyr Asn Ser Lys Lys Tyr Asp 
    210                 215                 220                 


Cys Cys Ala Glu Ile Tyr Pro Asp Val Xaa Tyr Ala Phe Val Ile Arg 
225                 230                 235                 240 


Arg Leu Pro Leu Phe Tyr Xaa Ile Asn Leu Ile Ile Pro Cys Leu Leu 
                245                 250                 255     


Ile Ser Cys Leu Xaa Val Leu Val Phe Tyr Leu Pro Ser Asp Cys Gly 
            260                 265                 270         


Glu Lys Ile Xaa Leu Cys Ile Ser Val Leu Leu Ser Leu Xaa Val Phe 
        275                 280                 285             


Leu Leu Leu Ile Xaa Glu Ile Ile Pro Ser Xaa Ser Leu Val Ile Pro 
    290                 295                 300                 


Leu Ile Gly Glu Tyr Leu Leu Phe Xaa Met Ile Phe Val Xaa Leu Ser 
305                 310                 315                 320 


Ile Val Ile Xaa Val Phe Val Leu Asn Val His His Arg Ser Pro Ser 
                325                 330                 335     


Xaa His Xaa Met Pro His Trp Val Arg Gly Ala Leu Leu Gly Cys Val 
            340                 345                 350         


Pro Arg Trp Leu Leu Met Asn Arg Pro Pro Pro Pro Val Glu Leu Cys 
        355                 360                 365             


His Pro Leu Arg Leu Lys Leu Ser Pro Ser Tyr His Trp Leu Glu Ser 
    370                 375                 380                 


Asn Val Asp Ala Glu Glu Arg Glu Val Val Val Glu Glu Glu Asp Arg 
385                 390                 395                 400 


Trp Ala Cys Ala Gly His Val Ala Pro Ser Val Gly Xaa Leu Cys Ser 
                405                 410                 415     


His Gly His Leu His Ser Gly Ala Ser Gly Pro Lys Ala Glu Ala Leu 
            420                 425                 430         


Leu Gln Glu Gly Glu Leu Leu Leu Ser Pro His Met Gln Lys Ala Leu 
        435                 440                 445             


Glu Gly Val His Tyr Ile Ala Asp His Leu Arg Ser Glu Asp Ala Asp 
    450                 455                 460                 


Ser Ser Val Lys Glu Asp Trp Lys Tyr Val Ala Met Val Ile Asp Arg 
465                 470                 475                 480 


Ile Phe Leu Trp Leu Phe Ile Ile Val Cys Phe Leu Gly Xaa Ile Gly 
                485                 490                 495     


Leu Phe Leu Pro Pro Phe Leu Ala Gly Met Ile 
            500                 505         


<210> 6153
<211> 19
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<400> 6153
Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Xaa Lys Leu Ser Leu 
1               5                   10                  15      


Trp Trp Leu 
            


<210> 6154
<211> 50
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<400> 6154
Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Xaa Lys Leu Ser Leu 
1               5                   10                  15      


Trp Trp Leu Leu Leu Xaa Pro Ala Gly Gly Glu Glu Ala Lys Arg Pro 
            20                  25                  30          


Pro Pro Arg Ala Pro Gly Asp Pro Leu Ser Ser Pro Ser Pro Xaa Ala 
        35                  40                  45              


Leu Pro 
    50  


<210> 6155
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 6155
Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Xaa Lys Leu Ser Leu 
1               5                   10                  15      


Trp Trp Leu Leu Leu Xaa Pro Ala Gly Gly Glu Glu Ala Lys Arg Pro 
            20                  25                  30          


Pro Pro Arg Ala Pro Gly Asp Pro Leu Ser Ser Pro Ser Pro Xaa Ala 
        35                  40                  45              


Leu Pro Gln Gly Gly Ser His Xaa Glu Xaa Glu Asp Arg Leu Phe Lys 
    50                  55                  60                  


His Leu Phe Arg Gly Tyr Asn Arg Trp Ala Arg Pro Val Pro Asn Xaa 
65                  70                  75                  80  


Ser 
    


<210> 6156
<211> 514
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<400> 6156
Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Xaa Lys Leu Ser Leu 
1               5                   10                  15      


Trp Trp Leu Leu Leu Xaa Pro Ala Gly Gly Glu Glu Ala Lys Arg Pro 
            20                  25                  30          


Pro Pro Arg Ala Pro Gly Asp Pro Leu Ser Ser Pro Ser Pro Xaa Ala 
        35                  40                  45              


Leu Pro Gln Gly Gly Ser His Xaa Glu Xaa Glu Asp Arg Leu Phe Lys 
    50                  55                  60                  


His Leu Phe Arg Gly Tyr Asn Arg Trp Ala Arg Pro Val Pro Asn Xaa 
65                  70                  75                  80  


Ser Asp Val Asp Glu Lys Asn Gln Met Met Xaa Xaa Asn Val Trp Leu 
                85                  90                  95      


Lys Gln Glu Trp Ser Asp Tyr Lys Leu Arg Trp Asn Pro Xaa Asp Phe 
            100                 105                 110         


Gly Asn Ile Xaa Ser Leu Arg Val Pro Ser Glu Met Ile Trp Ile Pro 
        115                 120                 125             


Asp Ile Val Leu Tyr Asn Asn Ala Asp Gly Glu Phe Ala Val Xaa His 
    130                 135                 140                 


Met Xaa Lys Ala His Leu Phe Ser Xaa Gly Xaa Val His Trp Val Pro 
145                 150                 155                 160 


Pro Ala Ile Tyr Lys Ser Ser Cys Ser Ile Asp Val Xaa Phe Phe Pro 
                165                 170                 175     


Phe Asp Gln Gln Asn Cys Lys Met Lys Phe Gly Ser Trp Xaa Tyr Asp 
            180                 185                 190         


Lys Ala Lys Ile Asp Leu Glu Gln Met Glu Gln Xaa Val Asp Leu Lys 
        195                 200                 205             


Asp Tyr Trp Glu Ser Gly Glu Trp Ala Ile Val Asn Ala Xaa Gly Xaa 
    210                 215                 220                 


Tyr Asn Ser Lys Lys Tyr Asp Cys Cys Ala Glu Ile Tyr Pro Asp Val 
225                 230                 235                 240 


Xaa Tyr Ala Phe Val Ile Arg Arg Leu Pro Leu Phe Tyr Xaa Ile Asn 
                245                 250                 255     


Leu Ile Ile Pro Cys Leu Leu Ile Ser Cys Leu Xaa Val Leu Val Phe 
            260                 265                 270         


Tyr Leu Pro Ser Asp Cys Gly Glu Lys Ile Xaa Leu Cys Ile Ser Val 
        275                 280                 285             


Leu Leu Ser Leu Xaa Val Phe Leu Leu Leu Ile Xaa Glu Ile Ile Pro 
    290                 295                 300                 


Ser Xaa Ser Leu Val Ile Pro Leu Ile Gly Glu Tyr Leu Leu Phe Xaa 
305                 310                 315                 320 


Met Ile Phe Val Xaa Leu Ser Ile Val Ile Xaa Val Phe Val Leu Asn 
                325                 330                 335     


Val His His Arg Ser Pro Ser Xaa His Xaa Met Pro His Trp Val Arg 
            340                 345                 350         


Gly Ala Leu Leu Gly Cys Val Pro Arg Trp Leu Leu Met Asn Arg Pro 
        355                 360                 365             


Pro Pro Pro Val Glu Leu Cys His Pro Leu Arg Leu Lys Leu Ser Pro 
    370                 375                 380                 


Ser Tyr His Trp Leu Glu Ser Asn Val Asp Ala Glu Glu Arg Glu Val 
385                 390                 395                 400 


Val Val Glu Glu Glu Asp Arg Trp Ala Cys Ala Gly His Val Ala Pro 
                405                 410                 415     


Ser Val Gly Xaa Leu Cys Ser His Gly His Leu His Ser Gly Ala Ser 
            420                 425                 430         


Gly Pro Lys Ala Glu Ala Leu Leu Gln Glu Gly Glu Leu Leu Leu Ser 
        435                 440                 445             


Pro His Met Gln Lys Ala Leu Glu Gly Val His Tyr Ile Ala Asp His 
    450                 455                 460                 


Leu Arg Ser Glu Asp Ala Asp Ser Ser Val Lys Glu Asp Trp Lys Tyr 
465                 470                 475                 480 


Val Ala Met Val Ile Asp Arg Ile Phe Leu Trp Leu Phe Ile Ile Val 
                485                 490                 495     


Cys Phe Leu Gly Xaa Ile Gly Leu Phe Leu Pro Pro Phe Leu Ala Gly 
            500                 505                 510         


Met Ile 
        


<210> 6157
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(107)
<223> Selenocysteine

<400> 6157
Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Xaa Lys Leu Ser Leu 
1               5                   10                  15      


Trp Trp Leu Leu Leu Xaa Pro Ala Gly Gly Glu Glu Ala Lys Arg Pro 
            20                  25                  30          


Pro Pro Arg Ala Pro Gly Asp Pro Leu Ser Ser Pro Ser Pro Xaa Ala 
        35                  40                  45              


Leu Pro Gln Gly Gly Ser His Xaa Glu Xaa Glu Asp Arg Leu Phe Lys 
    50                  55                  60                  


His Leu Phe Arg Gly Tyr Asn Arg Trp Ala Arg Pro Val Pro Asn Xaa 
65                  70                  75                  80  


Ser Asp Val Val Ile Val Arg Phe Gly Leu Ser Ile Ala Gln Leu Ile 
                85                  90                  95      


Asp Val Asp Glu Lys Asn Gln Met Met Xaa Xaa Asn 
            100                 105             


<210> 6158
<211> 529
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<400> 6158
Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Xaa Lys Leu Ser Leu 
1               5                   10                  15      


Trp Trp Leu Leu Leu Xaa Pro Ala Gly Gly Glu Glu Ala Lys Arg Pro 
            20                  25                  30          


Pro Pro Arg Ala Pro Gly Asp Pro Leu Ser Ser Pro Ser Pro Xaa Ala 
        35                  40                  45              


Leu Pro Gln Gly Gly Ser His Xaa Glu Xaa Glu Asp Arg Leu Phe Lys 
    50                  55                  60                  


His Leu Phe Arg Gly Tyr Asn Arg Trp Ala Arg Pro Val Pro Asn Xaa 
65                  70                  75                  80  


Ser Asp Val Val Ile Val Arg Phe Gly Leu Ser Ile Ala Gln Leu Ile 
                85                  90                  95      


Asp Val Asp Glu Lys Asn Gln Met Met Xaa Xaa Asn Val Trp Leu Lys 
            100                 105                 110         


Gln Glu Trp Ser Asp Tyr Lys Leu Arg Trp Asn Pro Xaa Asp Phe Gly 
        115                 120                 125             


Asn Ile Xaa Ser Leu Arg Val Pro Ser Glu Met Ile Trp Ile Pro Asp 
    130                 135                 140                 


Ile Val Leu Tyr Asn Asn Ala Asp Gly Glu Phe Ala Val Xaa His Met 
145                 150                 155                 160 


Xaa Lys Ala His Leu Phe Ser Xaa Gly Xaa Val His Trp Val Pro Pro 
                165                 170                 175     


Ala Ile Tyr Lys Ser Ser Cys Ser Ile Asp Val Xaa Phe Phe Pro Phe 
            180                 185                 190         


Asp Gln Gln Asn Cys Lys Met Lys Phe Gly Ser Trp Xaa Tyr Asp Lys 
        195                 200                 205             


Ala Lys Ile Asp Leu Glu Gln Met Glu Gln Xaa Val Asp Leu Lys Asp 
    210                 215                 220                 


Tyr Trp Glu Ser Gly Glu Trp Ala Ile Val Asn Ala Xaa Gly Xaa Tyr 
225                 230                 235                 240 


Asn Ser Lys Lys Tyr Asp Cys Cys Ala Glu Ile Tyr Pro Asp Val Xaa 
                245                 250                 255     


Tyr Ala Phe Val Ile Arg Arg Leu Pro Leu Phe Tyr Xaa Ile Asn Leu 
            260                 265                 270         


Ile Ile Pro Cys Leu Leu Ile Ser Cys Leu Xaa Val Leu Val Phe Tyr 
        275                 280                 285             


Leu Pro Ser Asp Cys Gly Glu Lys Ile Xaa Leu Cys Ile Ser Val Leu 
    290                 295                 300                 


Leu Ser Leu Xaa Val Phe Leu Leu Leu Ile Xaa Glu Ile Ile Pro Ser 
305                 310                 315                 320 


Xaa Ser Leu Val Ile Pro Leu Ile Gly Glu Tyr Leu Leu Phe Xaa Met 
                325                 330                 335     


Ile Phe Val Xaa Leu Ser Ile Val Ile Xaa Val Phe Val Leu Asn Val 
            340                 345                 350         


His His Arg Ser Pro Ser Xaa His Xaa Met Pro His Trp Val Arg Gly 
        355                 360                 365             


Ala Leu Leu Gly Cys Val Pro Arg Trp Leu Leu Met Asn Arg Pro Pro 
    370                 375                 380                 


Pro Pro Val Glu Leu Cys His Pro Leu Arg Leu Lys Leu Ser Pro Ser 
385                 390                 395                 400 


Tyr His Trp Leu Glu Ser Asn Val Asp Ala Glu Glu Arg Glu Val Val 
                405                 410                 415     


Val Glu Glu Glu Asp Arg Trp Ala Cys Ala Gly His Val Ala Pro Ser 
            420                 425                 430         


Val Gly Xaa Leu Cys Ser His Gly His Leu His Ser Gly Ala Ser Gly 
        435                 440                 445             


Pro Lys Ala Glu Ala Leu Leu Gln Glu Gly Glu Leu Leu Leu Ser Pro 
    450                 455                 460                 


His Met Gln Lys Ala Leu Glu Gly Val His Tyr Ile Ala Asp His Leu 
465                 470                 475                 480 


Arg Ser Glu Asp Ala Asp Ser Ser Val Lys Glu Asp Trp Lys Tyr Val 
                485                 490                 495     


Ala Met Val Ile Asp Arg Ile Phe Leu Trp Leu Phe Ile Ile Val Cys 
            500                 505                 510         


Phe Leu Gly Xaa Ile Gly Leu Phe Leu Pro Pro Phe Leu Ala Gly Met 
        515                 520                 525             


Ile 
    


<210> 6159
<211> 154
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<400> 6159
Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Xaa Lys Leu Ser Leu 
1               5                   10                  15      


Trp Trp Leu Leu Leu Xaa Pro Ala Gly Gly Glu Glu Ala Lys Arg Pro 
            20                  25                  30          


Pro Pro Arg Ala Pro Gly Asp Pro Leu Ser Ser Pro Ser Pro Xaa Ala 
        35                  40                  45              


Leu Pro Gln Gly Gly Ser His Xaa Glu Xaa Glu Asp Arg Leu Phe Lys 
    50                  55                  60                  


His Leu Phe Arg Gly Tyr Asn Arg Trp Ala Arg Pro Val Pro Asn Xaa 
65                  70                  75                  80  


Ser Asp Val Val Ile Val Arg Phe Gly Leu Ser Ile Ala Gln Leu Ile 
                85                  90                  95      


Asp Val Asp Glu Lys Asn Gln Met Met Xaa Xaa Asn Val Trp Leu Lys 
            100                 105                 110         


Gln Glu Trp Ser Asp Tyr Lys Leu Arg Trp Asn Pro Xaa Asp Phe Gly 
        115                 120                 125             


Asn Ile Xaa Ser Leu Arg Val Pro Ser Glu Met Ile Trp Ile Pro Asp 
    130                 135                 140                 


Ile Val Leu Tyr Asn Asn Arg Xaa Ala Arg 
145                 150                 


<210> 6160
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 6160
Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Xaa Lys Leu Ser Leu 
1               5                   10                  15      


Trp Trp Leu Leu Leu Xaa Pro Ala Gly Gly Glu Glu Ala Lys Arg Pro 
            20                  25                  30          


Pro Pro Arg Ala Pro Gly Asp Pro Leu Ser Ser Pro Ser Pro Xaa Ala 
        35                  40                  45              


Leu Pro Gln Gly Gly Ser His Xaa Glu Xaa Glu Asp Arg Leu Phe Lys 
    50                  55                  60                  


His Leu Phe Arg Gly Tyr Asn Arg Trp Ala Arg Pro Val Pro Asn Xaa 
65                  70                  75                  80  


Ser Asp Val Val Ile Val Arg Phe Gly Leu Ser Ile Ala Gln Leu Ile 
                85                  90                  95      


Asp Val Val Arg Leu Ser Ser His Arg Trp Pro Glu Glu Gly Asp Pro 
            100                 105                 110         


Arg Pro Pro Xaa Ala Phe Pro Leu Leu Leu Pro Leu Pro Gln Pro Cys 
        115                 120                 125             


Pro His Ala Gln Gln 
    130             


<210> 6161
<211> 489
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<400> 6161
Met Gly Ser Gly Pro Leu Ser Leu Pro Leu Ala Leu Ser Pro Pro Arg 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Ser Leu Leu Pro Val Ala Arg Ala Ser 
            20                  25                  30          


Glu Ala Glu His Arg Leu Phe Glu Arg Leu Phe Glu Asp Tyr Asn Glu 
        35                  40                  45              


Ile Ile Arg Pro Val Ala Asn Val Ser Asp Pro Val Ile Ile His Phe 
    50                  55                  60                  


Glu Val Ser Met Ser Gln Leu Val Lys Val Asp Glu Val Asn Gln Ile 
65                  70                  75                  80  


Met Glu Xaa Asn Leu Trp Leu Lys Gln Ile Trp Asn Asp Tyr Lys Leu 
                85                  90                  95      


Lys Trp Asn Pro Ser Asp Tyr Gly Gly Ala Glu Phe Met Arg Val Pro 
            100                 105                 110         


Ala Gln Lys Ile Trp Lys Pro Asp Ile Val Leu Tyr Asn Asn Ala Val 
        115                 120                 125             


Gly Asp Phe Gln Val Asp Asp Lys Xaa Lys Ala Leu Leu Lys Tyr Xaa 
    130                 135                 140                 


Gly Glu Val Xaa Trp Ile Pro Pro Ala Ile Phe Lys Ser Ser Cys Lys 
145                 150                 155                 160 


Ile Asp Val Xaa Tyr Phe Pro Phe Asp Tyr Gln Asn Cys Xaa Met Lys 
                165                 170                 175     


Phe Gly Ser Trp Ser Tyr Asp Lys Ala Lys Ile Asp Leu Val Leu Ile 
            180                 185                 190         


Gly Ser Ser Met Asn Leu Lys Asp Tyr Trp Glu Ser Gly Glu Trp Ala 
        195                 200                 205             


Ile Ile Lys Ala Pro Gly Tyr Lys His Asp Ile Lys Tyr Asn Cys Cys 
    210                 215                 220                 


Glu Glu Ile Tyr Pro Asp Ile Xaa Tyr Ser Leu Tyr Ile Arg Arg Leu 
225                 230                 235                 240 


Pro Leu Phe Tyr Xaa Ile Asn Leu Ile Ile Pro Cys Leu Leu Ile Ser 
                245                 250                 255     


Phe Leu Xaa Val Leu Val Phe Tyr Leu Pro Ser Asp Cys Gly Glu Lys 
            260                 265                 270         


Val Xaa Leu Cys Ile Ser Val Leu Leu Ser Leu Xaa Val Phe Leu Leu 
        275                 280                 285             


Val Ile Xaa Glu Xaa Ile Pro Ser Xaa Ser Leu Val Ile Pro Leu Ile 
    290                 295                 300                 


Gly Glu Tyr Leu Leu Phe Xaa Met Ile Phe Val Xaa Leu Ser Ile Val 
305                 310                 315                 320 


Ile Xaa Val Phe Val Leu Asn Val His Tyr Arg Xaa Pro Xaa Xaa His 
                325                 330                 335     


Xaa Met Pro Ser Trp Val Lys Xaa Val Phe Leu Asn Leu Leu Pro Arg 
            340                 345                 350         


Val Met Phe Met Xaa Arg Pro Xaa Ser Asn Glu Gly Asn Ala Gln Lys 
        355                 360                 365             


Pro Arg Pro Leu Tyr Gly Ala Glu Leu Ser Asn Leu Asn Cys Phe Ser 
    370                 375                 380                 


Arg Ala Glu Ser Lys Gly Cys Lys Glu Gly Tyr Pro Cys Gln Asp Gly 
385                 390                 395                 400 


Met Cys Gly Tyr Cys His His Arg Arg Ile Lys Ile Ser Asn Phe Ser 
                405                 410                 415     


Ala Asn Leu Xaa Arg Ser Ser Ser Ser Glu Ser Val Asp Ala Val Leu 
            420                 425                 430         


Ser Leu Ser Ala Leu Ser Pro Glu Ile Lys Glu Ala Ile Gln Ser Val 
        435                 440                 445             


Lys Tyr Ile Ala Glu Asn Met Lys Ala Gln Asn Glu Ala Lys Glu Glu 
    450                 455                 460                 


Gln Lys Ala Gln Glu Ile Gln Gln Leu Lys Arg Lys Glu Lys Ser Xaa 
465                 470                 475                 480 


Glu Xaa Ser Asp Gln Glu Pro Gly Leu 
                485                 


<210> 6162
<211> 505
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<400> 6162
Met Gly Ser Gly Pro Leu Ser Leu Pro Leu Ala Leu Ser Pro Pro Arg 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Ser Leu Leu Pro Val Ala Arg Ala Ser 
            20                  25                  30          


Glu Ala Glu His Arg Leu Phe Glu Arg Leu Phe Glu Asp Tyr Asn Glu 
        35                  40                  45              


Ile Ile Arg Pro Val Ala Asn Val Ser Asp Pro Val Ile Ile His Phe 
    50                  55                  60                  


Glu Val Ser Met Ser Gln Leu Val Lys Val Asp Glu Val Asn Gln Ile 
65                  70                  75                  80  


Met Glu Xaa Asn Leu Trp Leu Lys Gln Ile Trp Asn Asp Tyr Lys Leu 
                85                  90                  95      


Lys Trp Asn Pro Ser Asp Tyr Gly Gly Ala Glu Phe Met Arg Val Pro 
            100                 105                 110         


Ala Gln Lys Ile Trp Lys Pro Asp Ile Val Leu Tyr Asn Asn Ala Val 
        115                 120                 125             


Gly Asp Phe Gln Val Asp Asp Lys Xaa Lys Ala Leu Leu Lys Tyr Xaa 
    130                 135                 140                 


Gly Glu Val Xaa Trp Ile Pro Pro Ala Ile Phe Lys Ser Ser Cys Lys 
145                 150                 155                 160 


Ile Asp Val Xaa Tyr Phe Pro Phe Asp Tyr Gln Asn Cys Xaa Met Lys 
                165                 170                 175     


Phe Gly Ser Trp Ser Tyr Asp Lys Ala Lys Ile Asp Leu Val Leu Ile 
            180                 185                 190         


Gly Ser Ser Met Asn Leu Lys Asp Tyr Trp Glu Ser Gly Glu Trp Ala 
        195                 200                 205             


Ile Ile Lys Ala Pro Gly Tyr Lys His Asp Ile Lys Tyr Asn Cys Cys 
    210                 215                 220                 


Glu Glu Ile Tyr Pro Asp Ile Xaa Tyr Ser Leu Tyr Ile Arg Arg Leu 
225                 230                 235                 240 


Pro Leu Phe Tyr Xaa Ile Asn Leu Ile Ile Pro Cys Leu Leu Ile Ser 
                245                 250                 255     


Phe Leu Xaa Val Leu Val Phe Tyr Leu Pro Ser Asp Cys Gly Glu Lys 
            260                 265                 270         


Val Xaa Leu Cys Ile Ser Val Leu Leu Ser Leu Xaa Val Phe Leu Leu 
        275                 280                 285             


Val Ile Xaa Glu Xaa Ile Pro Ser Xaa Ser Leu Val Ile Pro Leu Ile 
    290                 295                 300                 


Gly Glu Tyr Leu Leu Phe Xaa Met Ile Phe Val Xaa Leu Ser Ile Val 
305                 310                 315                 320 


Ile Xaa Val Phe Val Leu Asn Val His Tyr Arg Xaa Pro Xaa Xaa His 
                325                 330                 335     


Xaa Met Pro Ser Trp Val Lys Xaa Val Phe Leu Asn Leu Leu Pro Arg 
            340                 345                 350         


Val Met Phe Met Xaa Arg Pro Xaa Ser Asn Glu Gly Asn Ala Gln Lys 
        355                 360                 365             


Pro Arg Pro Leu Tyr Gly Ala Glu Leu Ser Asn Leu Asn Cys Phe Ser 
    370                 375                 380                 


Arg Ala Glu Ser Lys Gly Cys Lys Glu Gly Tyr Pro Cys Gln Asp Gly 
385                 390                 395                 400 


Met Cys Gly Tyr Cys His His Arg Arg Ile Lys Ile Ser Asn Phe Ser 
                405                 410                 415     


Ala Asn Leu Xaa Arg Ser Ser Ser Ser Glu Ser Val Asp Ala Val Leu 
            420                 425                 430         


Ser Leu Ser Ala Leu Ser Pro Glu Ile Lys Glu Ala Ile Gln Ser Val 
        435                 440                 445             


Lys Tyr Ile Ala Glu Asn Met Lys Ala Gln Asn Glu Ala Lys Glu Ile 
    450                 455                 460                 


Gln Asp Asp Trp Lys Tyr Val Ala Met Val Ile Asp Arg Ile Phe Leu 
465                 470                 475                 480 


Trp Val Phe Xaa Leu Val Cys Ile Leu Gly Xaa Ala Gly Leu Phe Leu 
                485                 490                 495     


Gln Pro Leu Met Ala Arg Glu Asp Ala 
            500                 505 


<210> 6163
<211> 18
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<400> 6163
Met Ser Gln Leu Val Lys Val Asp Glu Val Asn Gln Ile Met Glu Xaa 
1               5                   10                  15      


Asn Leu 
        


<210> 6164
<211> 627
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<400> 6164
Met Glu Leu Gly Gly Pro Gly Ala Pro Arg Leu Leu Pro Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Gly Xaa Gly Leu Leu Arg Ala Ser Ser His Val Glu Xaa 
            20                  25                  30          


Arg Ala His Ala Glu Glu Arg Leu Leu Lys Lys Leu Phe Ser Gly Tyr 
        35                  40                  45              


Asn Lys Trp Ser Arg Pro Val Ala Asn Ile Ser Asp Val Val Leu Val 
    50                  55                  60                  


Arg Phe Gly Leu Ser Ile Ala Gln Leu Ile Asp Val Asp Glu Lys Asn 
65                  70                  75                  80  


Gln Met Met Xaa Xaa Asn Val Trp Val Lys Gln Glu Trp His Asp Tyr 
                85                  90                  95      


Lys Leu Arg Trp Asp Pro Ala Asp Tyr Glu Asn Val Xaa Ser Ile Arg 
            100                 105                 110         


Ile Pro Ser Glu Leu Ile Trp Arg Pro Asp Ile Val Leu Tyr Asn Asn 
        115                 120                 125             


Ala Asp Gly Asp Phe Ala Val Xaa His Leu Xaa Lys Ala His Leu Phe 
    130                 135                 140                 


His Asp Gly Arg Val Gln Trp Xaa Pro Pro Ala Ile Tyr Lys Ser Ser 
145                 150                 155                 160 


Cys Ser Ile Asp Val Xaa Phe Phe Pro Phe Asp Gln Gln Asn Cys Xaa 
                165                 170                 175     


Met Lys Phe Gly Ser Trp Xaa Tyr Asp Lys Ala Lys Ile Asp Leu Val 
            180                 185                 190         


Asn Met His Ser Arg Val Asp Gln Leu Asp Phe Trp Glu Ser Gly Glu 
        195                 200                 205             


Trp Val Ile Val Asp Ala Val Gly Xaa Tyr Asn Xaa Arg Lys Tyr Glu 
    210                 215                 220                 


Cys Cys Ala Glu Ile Tyr Pro Asp Ile Xaa Tyr Ala Phe Val Ile Arg 
225                 230                 235                 240 


Arg Leu Pro Leu Phe Tyr Xaa Ile Asn Leu Ile Ile Pro Cys Leu Leu 
                245                 250                 255     


Ile Ser Cys Leu Xaa Val Leu Val Phe Tyr Leu Pro Ser Glu Cys Gly 
            260                 265                 270         


Glu Lys Ile Xaa Leu Cys Ile Ser Val Leu Leu Ser Leu Xaa Val Phe 
        275                 280                 285             


Leu Leu Leu Ile Xaa Glu Ile Ile Pro Ser Xaa Ser Leu Val Ile Pro 
    290                 295                 300                 


Leu Ile Gly Glu Tyr Leu Leu Phe Xaa Met Ile Phe Val Xaa Leu Ser 
305                 310                 315                 320 


Ile Val Ile Xaa Val Phe Val Leu Asn Val His His Arg Ser Pro Arg 
                325                 330                 335     


Xaa His Xaa Met Pro Xaa Trp Val Arg Arg Val Phe Leu Asp Ile Val 
            340                 345                 350         


Pro Arg Leu Leu Leu Met Lys Arg Pro Ser Val Val Lys Asp Asn Cys 
        355                 360                 365             


Arg Arg Leu Ile Glu Ser Met His Lys Met Ala Ser Ala Pro Arg Phe 
    370                 375                 380                 


Trp Pro Glu Pro Glu Gly Glu Pro Pro Ala Xaa Ser Gly Xaa Gln Ser 
385                 390                 395                 400 


Leu His Pro Pro Ser Pro Ser Phe Cys Val Pro Leu Asp Val Pro Ala 
                405                 410                 415     


Glu Pro Gly Pro Ser Cys Lys Ser Pro Ser Asp Gln Leu Pro Pro Gln 
            420                 425                 430         


Gln Pro Leu Glu Ala Glu Lys Ala Ser Pro His Pro Ser Pro Gly Pro 
        435                 440                 445             


Cys Arg Pro Pro His Gly Xaa Gln Ala Pro Gly Leu Ala Lys Ala Arg 
    450                 455                 460                 


Ser Leu Ser Val Gln His Met Ser Ser Pro Gly Glu Ala Val Glu Gly 
465                 470                 475                 480 


Gly Val Arg Cys Arg Ser Arg Ser Ile Gln Tyr Cys Val Pro Arg Asp 
                485                 490                 495     


Asp Ala Ala Pro Glu Ala Asp Gly Gln Ala Ala Gly Ala Leu Ala Ser 
            500                 505                 510         


Arg Asn Xaa His Ser Ala Glu Leu Pro Pro Pro Asp Gln Pro Ser Pro 
        515                 520                 525             


Cys Lys Cys Xaa Cys Lys Lys Glu Pro Ser Ser Val Ser Pro Ser Ala 
    530                 535                 540                 


Xaa Val Lys Xaa Arg Ser Xaa Lys Ala Pro Pro Pro His Leu Pro Leu 
545                 550                 555                 560 


Ser Pro Ala Leu Xaa Arg Ala Val Glu Gly Val Gln Tyr Ile Ala Asp 
                565                 570                 575     


His Leu Lys Ala Glu Asp Xaa Asp Phe Ser Val Lys Glu Asp Trp Lys 
            580                 585                 590         


Tyr Val Ala Met Val Ile Asp Arg Ile Phe Leu Trp Met Phe Ile Ile 
        595                 600                 605             


Val Cys Leu Leu Gly Xaa Val Gly Leu Phe Leu Pro Pro Trp Leu Ala 
    610                 615                 620                 


Gly Met Ile 
625         


<210> 6165
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(85)
<223> Selenocysteine

<400> 6165
Met Glu Leu Gly Gly Pro Gly Ala Pro Arg Leu Leu Pro Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Gly Xaa Gly Leu Leu Arg Ala Ser Ser His Val Glu Xaa 
            20                  25                  30          


Arg Ala His Ala Glu Glu Arg Leu Leu Lys Lys Leu Phe Ser Gly Tyr 
        35                  40                  45              


Asn Lys Trp Ser Arg Pro Val Ala Asn Ile Ser Asp Val Val Leu Val 
    50                  55                  60                  


Arg Phe Gly Leu Ser Ile Ala Gln Leu Ile Asp Val Asp Glu Lys Asn 
65                  70                  75                  80  


Gln Met Met Xaa Xaa Asn Val Trp Val Lys Gln Pro Pro Pro Ala Pro 
                85                  90                  95      


Pro His Pro Gly Val Ala Arg Leu Gln Ala Ala Leu Gly Pro Ser 
            100                 105                 110     


<210> 6166
<211> 556
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<400> 6166
Met Arg Met Ser Pro Pro Ser Ala Ser Pro Pro Ser Ser Ser Gly Gly 
1               5                   10                  15      


Arg Xaa Ser Ser Ser Xaa Xaa Xaa Ala Gly Glu Pro Phe Trp Ala Gly 
            20                  25                  30          


Val Leu Phe Ala Ile Arg Pro His Pro Gly Leu Ser Gly Arg Ile Val 
        35                  40                  45              


Trp Xaa Ala Gly Cys Pro Gly Glu Gly Ala Asp Gly Asp Phe Ala Val 
    50                  55                  60                  


Xaa His Leu Xaa Lys Ala His Leu Phe His Asp Gly Arg Val Gln Trp 
65                  70                  75                  80  


Xaa Pro Pro Ala Ile Tyr Lys Ser Ser Cys Ser Ile Asp Val Xaa Phe 
                85                  90                  95      


Phe Pro Phe Asp Gln Gln Asn Cys Xaa Met Lys Phe Gly Ser Trp Xaa 
            100                 105                 110         


Tyr Asp Lys Ala Lys Ile Asp Leu Val Asn Met His Ser Arg Val Asp 
        115                 120                 125             


Gln Leu Asp Phe Trp Glu Ser Gly Glu Trp Val Ile Val Asp Ala Val 
    130                 135                 140                 


Gly Xaa Tyr Asn Xaa Arg Lys Tyr Glu Cys Cys Ala Glu Ile Tyr Pro 
145                 150                 155                 160 


Asp Ile Xaa Tyr Ala Phe Val Ile Arg Arg Leu Pro Leu Phe Tyr Xaa 
                165                 170                 175     


Ile Asn Leu Ile Ile Pro Cys Leu Leu Ile Ser Cys Leu Xaa Val Leu 
            180                 185                 190         


Val Phe Tyr Leu Pro Ser Glu Cys Gly Glu Lys Ile Xaa Leu Cys Ile 
        195                 200                 205             


Ser Val Leu Leu Ser Leu Xaa Val Phe Leu Leu Leu Ile Xaa Glu Ile 
    210                 215                 220                 


Ile Pro Ser Xaa Ser Leu Val Ile Pro Leu Ile Gly Glu Tyr Leu Leu 
225                 230                 235                 240 


Phe Xaa Met Ile Phe Val Xaa Leu Ser Ile Val Ile Xaa Val Phe Val 
                245                 250                 255     


Leu Asn Val His His Arg Ser Pro Arg Xaa His Xaa Met Pro Xaa Trp 
            260                 265                 270         


Val Arg Arg Val Phe Leu Asp Ile Val Pro Arg Leu Leu Leu Met Lys 
        275                 280                 285             


Arg Pro Ser Val Val Lys Asp Asn Cys Arg Arg Leu Ile Glu Ser Met 
    290                 295                 300                 


His Lys Met Ala Ser Ala Pro Arg Phe Trp Pro Glu Pro Glu Gly Glu 
305                 310                 315                 320 


Pro Pro Ala Xaa Ser Gly Xaa Gln Ser Leu His Pro Pro Ser Pro Ser 
                325                 330                 335     


Phe Cys Val Pro Leu Asp Val Pro Ala Glu Pro Gly Pro Ser Cys Lys 
            340                 345                 350         


Ser Pro Ser Asp Gln Leu Pro Pro Gln Gln Pro Leu Glu Ala Glu Lys 
        355                 360                 365             


Ala Ser Pro His Pro Ser Pro Gly Pro Cys Arg Pro Pro His Gly Xaa 
    370                 375                 380                 


Gln Ala Pro Gly Leu Ala Lys Ala Arg Ser Leu Ser Val Gln His Met 
385                 390                 395                 400 


Ser Ser Pro Gly Glu Ala Val Glu Gly Gly Val Arg Cys Arg Ser Arg 
                405                 410                 415     


Ser Ile Gln Tyr Cys Val Pro Arg Asp Asp Ala Ala Pro Glu Ala Asp 
            420                 425                 430         


Gly Gln Ala Ala Gly Ala Leu Ala Ser Arg Asn Xaa His Ser Ala Glu 
        435                 440                 445             


Leu Pro Pro Pro Asp Gln Pro Ser Pro Cys Lys Cys Xaa Cys Lys Lys 
    450                 455                 460                 


Glu Pro Ser Ser Val Ser Pro Ser Ala Xaa Val Lys Xaa Arg Ser Xaa 
465                 470                 475                 480 


Lys Ala Pro Pro Pro His Leu Pro Leu Ser Pro Ala Leu Xaa Arg Ala 
                485                 490                 495     


Val Glu Gly Val Gln Tyr Ile Ala Asp His Leu Lys Ala Glu Asp Xaa 
            500                 505                 510         


Asp Phe Ser Val Lys Glu Asp Trp Lys Tyr Val Ala Met Val Ile Asp 
        515                 520                 525             


Arg Ile Phe Leu Trp Met Phe Ile Ile Val Cys Leu Leu Gly Xaa Val 
    530                 535                 540                 


Gly Leu Phe Leu Pro Pro Trp Leu Ala Gly Met Ile 
545                 550                 555     


<210> 6167
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<400> 6167
Xaa Ser Ser His Val Glu Xaa Arg Ala His Ala Glu Glu Arg Leu Leu 
1               5                   10                  15      


Lys Lys Leu Phe Ser Gly Tyr Asn Lys Trp Ser Arg Pro Val Ala Asn 
            20                  25                  30          


Ile Ser Asp Val Val Leu Val Arg Phe Gly Leu Ser Ile Ala Gln Leu 
        35                  40                  45              


Ile Asp Val Asp Glu Lys Asn Gln Met Met Xaa Xaa Asn Val Trp Val 
    50                  55                  60                  


Lys Gln Glu Trp His Asp Tyr Lys Leu Arg Trp Asp Pro Ala Asp Tyr 
65                  70                  75                  80  


Glu Asn Val Xaa Ser Ile Arg Ile Pro Ser Glu Leu Ile Trp Arg Pro 
                85                  90                  95      


Asp Ile Val Leu Tyr Asn Asn Cys Arg Arg Ala Leu Leu Gly Arg Ser 
            100                 105                 110         


Ala Phe Arg His Gln Xaa Pro Ser Trp Pro Phe Trp Glu Asn Ser Val 
        115                 120                 125             


Asp Cys Arg Val Pro Trp Arg Gly Cys 
    130                 135         


<210> 6168
<211> 160
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (94)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 6168
Met Ala Ala Arg Gly Ser Gly Pro Arg Ala Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Val Gln Leu Val Ala Gly Arg Cys Gly Leu Ala Gly Ala Ala Gly Gly 
            20                  25                  30          


Ala Gln Arg Gly Leu Ser Glu Pro Ser Ser Ile Ala Lys His Glu Asp 
        35                  40                  45              


Ser Leu Leu Lys Asp Leu Phe Gln Asp Tyr Glu Arg Trp Val Arg Pro 
    50                  55                  60                  


Val Glu His Leu Asn Asp Lys Ile Lys Ile Lys Phe Gly Leu Ala Ile 
65                  70                  75                  80  


Ser Gln Leu Val Asp Val Asp Glu Lys Asn Gln Leu Met Xaa Xaa Asn 
                85                  90                  95      


Val Trp Leu Lys Gln Glu Trp Ile Asp Val Lys Leu Arg Trp Asn Pro 
            100                 105                 110         


Asp Asp Tyr Gly Gly Ile Lys Val Ile Arg Val Pro Ser Asp Ser Val 
        115                 120                 125             


Trp Xaa Pro Asp Ile Val Leu Phe Asp Asn Ala Asp Gly Arg Phe Glu 
    130                 135                 140                 


Gly Xaa Ser Xaa Lys Xaa Val Ile Arg Leu Leu Lys Ile Gly Asn Ser 
145                 150                 155                 160 


<210> 6169
<211> 468
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (94)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<400> 6169
Met Ala Ala Arg Gly Ser Gly Pro Arg Ala Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Val Gln Leu Val Ala Gly Arg Cys Gly Leu Ala Gly Ala Ala Gly Gly 
            20                  25                  30          


Ala Gln Arg Gly Leu Ser Glu Pro Ser Ser Ile Ala Lys His Glu Asp 
        35                  40                  45              


Ser Leu Leu Lys Asp Leu Phe Gln Asp Tyr Glu Arg Trp Val Arg Pro 
    50                  55                  60                  


Val Glu His Leu Asn Asp Lys Ile Lys Ile Lys Phe Gly Leu Ala Ile 
65                  70                  75                  80  


Ser Gln Leu Val Asp Val Asp Glu Lys Asn Gln Leu Met Xaa Xaa Asn 
                85                  90                  95      


Val Trp Leu Lys Gln Glu Trp Ile Asp Val Lys Leu Arg Trp Asn Pro 
            100                 105                 110         


Asp Asp Tyr Gly Gly Ile Lys Val Ile Arg Val Pro Ser Asp Ser Val 
        115                 120                 125             


Trp Xaa Pro Asp Ile Val Leu Phe Asp Asn Ala Asp Gly Arg Phe Glu 
    130                 135                 140                 


Gly Xaa Ser Xaa Lys Xaa Val Ile Arg Tyr Asn Gly Xaa Val Xaa Trp 
145                 150                 155                 160 


Xaa Pro Pro Ala Asn Tyr Lys Ser Ser Cys Xaa Ile Asp Val Xaa Phe 
                165                 170                 175     


Phe Pro Phe Asp Leu Gln Asn Cys Ser Met Lys Phe Gly Ser Trp Xaa 
            180                 185                 190         


Tyr Asp Gly Ser Gln Val Asp Ile Ile Leu Glu Asp Gln Asp Val Asp 
        195                 200                 205             


Lys Arg Asp Phe Phe Asp Asn Gly Glu Trp Glu Ile Val Ser Ala Xaa 
    210                 215                 220                 


Gly Ser Lys Gly Asn Arg Xaa Asp Ser Cys Cys Trp Tyr Pro Tyr Val 
225                 230                 235                 240 


Xaa Tyr Ser Phe Val Ile Lys Arg Leu Pro Leu Phe Tyr Xaa Leu Phe 
                245                 250                 255     


Leu Ile Ile Pro Cys Ile Gly Leu Ser Phe Leu Xaa Val Leu Val Phe 
            260                 265                 270         


Tyr Leu Pro Ser Asn Glu Gly Glu Lys Ile Cys Leu Cys Xaa Ser Val 
        275                 280                 285             


Leu Val Ser Leu Xaa Val Phe Leu Leu Val Ile Glu Glu Ile Ile Pro 
    290                 295                 300                 


Ser Ser Ser Lys Val Ile Pro Leu Ile Gly Glu Tyr Leu Val Phe Xaa 
305                 310                 315                 320 


Met Ile Phe Val Xaa Leu Ser Ile Met Val Xaa Val Phe Ala Ile Asn 
                325                 330                 335     


Ile His His Arg Ser Ser Ser Xaa His Asn Ala Met Ala Pro Leu Val 
            340                 345                 350         


Arg Lys Ile Phe Leu His Xaa Leu Pro Lys Leu Leu Cys Met Arg Ser 
        355                 360                 365             


His Val Asp Arg Tyr Phe Xaa Gln Lys Glu Glu Xaa Glu Ser Gly Ser 
    370                 375                 380                 


Gly Pro Lys Ser Ser Arg Asn Xaa Leu Glu Ala Ala Leu Asp Ser Ile 
385                 390                 395                 400 


Arg Tyr Ile Xaa Arg His Ile Met Lys Glu Asn Asp Val Arg Glu Val 
                405                 410                 415     


Val Glu Asp Trp Lys Phe Ile Ala Gln Val Leu Asp Arg Met Phe Leu 
            420                 425                 430         


Trp Xaa Phe Leu Phe Val Ser Ile Val Gly Ser Leu Gly Leu Phe Val 
        435                 440                 445             


Pro Val Ile Tyr Lys Trp Ala Asn Ile Leu Ile Pro Val His Ile Gly 
    450                 455                 460                 


Asn Ala Asn Lys 
465             


<210> 6170
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (33)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<400> 6170
Xaa Arg Pro Val Glu His Leu Asn Asp Lys Ile Lys Ile Lys Phe Gly 
1               5                   10                  15      


Leu Ala Ile Ser Gln Leu Val Asp Val Asp Glu Lys Asn Gln Leu Met 
            20                  25                  30          


Xaa Xaa Asn Val Trp Leu Lys Gln Glu Trp Ile Asp Val Lys Leu Arg 
        35                  40                  45              


Trp Asn Pro Asp Asp Tyr Gly Gly Ile Lys Val Ile Arg Val Pro Ser 
    50                  55                  60                  


Asp Ser Val Trp Xaa Pro Asp Ile Val Leu Phe Asp Asn Ala Asp Gly 
65                  70                  75                  80  


Arg Phe Glu Gly Xaa Ser Xaa Lys Xaa Val Ile Arg Tyr Asn Gly Xaa 
                85                  90                  95      


Val Xaa Trp Xaa Pro Pro Ala Asn Tyr Lys Ser Ser Cys Xaa Ile Asp 
            100                 105                 110         


Val Xaa Phe Phe Pro Phe Asp Leu Gln Asn Cys Ser Met Lys Phe Gly 
        115                 120                 125             


Ser Trp Xaa Tyr Asp Gly Ser Gln Val Asp Ile Ile Leu Glu Asp Gln 
    130                 135                 140                 


Asp Val Asp Lys Arg Asp Phe Phe Asp Asn Gly Glu Trp Glu Ile Val 
145                 150                 155                 160 


Ser Ala Xaa Gly Ser Lys Gly Asn Arg Xaa Asp Ser Cys Cys Trp Leu 
                165                 170                 175     


Leu Lys Ile Gly Asn Ser 
            180         


<210> 6171
<211> 56
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<400> 6171
Xaa Xaa Leu Ser Ile Met Val Xaa Val Phe Ala Ile Asn Ile His His 
1               5                   10                  15      


Arg Ser Ser Ser Xaa His Asn Ala Met Ala Pro Leu Val Arg Lys Ile 
            20                  25                  30          


Phe Leu His Xaa Leu Pro Lys Leu Leu Cys Met Arg Ser His Val Asp 
        35                  40                  45              


Arg Leu Leu Lys Ile Gly Asn Ser 
    50                  55      


<210> 6172
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<400> 6172
Met Glu Xaa Asn Leu Trp Leu Arg His Ile Trp Asn Asp Tyr Lys Leu 
1               5                   10                  15      


Arg Trp Asp Pro Met Glu Tyr Asp Gly Ile Glu Xaa Leu Arg Val Pro 
            20                  25                  30          


Ala Asp Lys Ile Trp Lys Pro Asp Ile Val Leu Tyr Asn Asn Ala Val 
        35                  40                  45              


Gly Asp Phe Gln Val Glu Gly Lys Xaa Lys Ala Leu Leu Lys Tyr Asn 
    50                  55                  60                  


Gly Met Ile Xaa Trp Xaa Pro Pro Ala Ile Phe Lys Ser Ser Cys Pro 
65                  70                  75                  80  


Met Asp Ile Xaa Phe Phe Pro Phe Asp His Gln Asn Cys Ser Leu Lys 
                85                  90                  95      


Phe Gly Ser Trp Xaa Tyr Asp Lys Ala Glu Ile Asp Leu Leu Ile 
            100                 105                 110     


<210> 6173
<211> 494
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<400> 6173
Met Leu Xaa Ser Lys Gly Gln Gly Phe Leu His Gly Gly Leu Cys Leu 
1               5                   10                  15      


Trp Leu Cys Val Phe Xaa Pro Phe Phe Lys Gly Cys Val Gly Cys Ala 
            20                  25                  30          


Xaa Glu Glu Arg Leu Phe His Lys Leu Phe Ser His Tyr Asn Gln Phe 
        35                  40                  45              


Ile Arg Pro Val Glu Asn Val Ser Asp Pro Val Xaa Val His Phe Glu 
    50                  55                  60                  


Val Ala Ile Xaa Gln Leu Ala Asn Val Asp Glu Val Asn Gln Ile Met 
65                  70                  75                  80  


Glu Xaa Asn Leu Trp Leu Arg His Ile Trp Asn Asp Tyr Lys Leu Arg 
                85                  90                  95      


Trp Asp Pro Met Glu Tyr Asp Gly Ile Glu Xaa Leu Arg Val Pro Ala 
            100                 105                 110         


Asp Lys Ile Trp Lys Pro Asp Ile Val Leu Tyr Asn Asn Ala Val Gly 
        115                 120                 125             


Asp Phe Gln Val Glu Gly Lys Xaa Lys Ala Leu Leu Lys Tyr Asn Gly 
    130                 135                 140                 


Met Ile Xaa Trp Xaa Pro Pro Ala Ile Phe Lys Ser Ser Cys Pro Met 
145                 150                 155                 160 


Asp Ile Xaa Phe Phe Pro Phe Asp His Gln Asn Cys Ser Leu Lys Phe 
                165                 170                 175     


Gly Ser Trp Xaa Tyr Asp Lys Ala Glu Ile Asp Leu Leu Ile Ile Gly 
            180                 185                 190         


Ser Lys Val Asp Met Asn Asp Phe Trp Glu Asn Ser Glu Trp Glu Ile 
        195                 200                 205             


Ile Asp Ala Ser Gly Tyr Lys His Asp Ile Lys Tyr Asn Cys Cys Glu 
    210                 215                 220                 


Glu Ile Tyr Xaa Asp Ile Xaa Tyr Ser Phe Tyr Ile Arg Arg Leu Pro 
225                 230                 235                 240 


Met Phe Tyr Xaa Ile Asn Leu Ile Ile Pro Cys Leu Phe Ile Ser Phe 
                245                 250                 255     


Leu Xaa Val Leu Val Phe Tyr Leu Pro Ser Asp Cys Gly Glu Lys Val 
            260                 265                 270         


Xaa Leu Cys Ile Ser Val Leu Leu Ser Leu Xaa Val Phe Leu Leu Val 
        275                 280                 285             


Ile Xaa Glu Xaa Ile Pro Ser Xaa Ser Leu Val Val Pro Leu Val Gly 
    290                 295                 300                 


Glu Tyr Leu Leu Phe Xaa Met Ile Phe Val Xaa Leu Ser Ile Val Val 
305                 310                 315                 320 


Xaa Val Phe Val Leu Asn Ile His Tyr Arg Xaa Pro Xaa Xaa His Xaa 
                325                 330                 335     


Met Pro Arg Trp Val Lys Xaa Val Phe Leu Lys Leu Leu Pro Gln Val 
            340                 345                 350         


Leu Leu Met Arg Trp Pro Leu Asp Lys Xaa Arg Gly Xaa Gly Ser Asp 
        355                 360                 365             


Ala Val Pro Arg Gly Leu Ala Arg Arg Pro Ala Lys Gly Lys Leu Ala 
    370                 375                 380                 


Ser His Gly Glu Pro Arg His Leu Lys Glu Cys Phe His Cys His Lys 
385                 390                 395                 400 


Ser Asn Glu Leu Ala Xaa Ser Lys Arg Arg Leu Ser His Gln Pro Leu 
                405                 410                 415     


Gln Trp Val Val Glu Asn Ser Glu His Ser Pro Glu Val Glu Asp Val 
            420                 425                 430         


Ile Asn Ser Val Gln Phe Ile Ala Glu Asn Met Lys Ser His Asn Glu 
        435                 440                 445             


Xaa Lys Glu Val Glu Asp Asp Trp Lys Tyr Val Ala Met Val Val Asp 
    450                 455                 460                 


Arg Val Phe Leu Trp Val Phe Ile Ile Val Cys Val Phe Gly Xaa Ala 
465                 470                 475                 480 


Gly Leu Phe Leu Gln Pro Leu Leu Gly Asn Xaa Gly Lys Ser 
                485                 490                 


<210> 6174
<211> 479
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<400> 6174
Met Leu Xaa Ser Lys Gly Gln Gly Phe Leu His Gly Gly Leu Cys Leu 
1               5                   10                  15      


Trp Leu Cys Val Phe Xaa Pro Phe Phe Lys Gly Cys Val Gly Cys Ala 
            20                  25                  30          


Xaa Glu Glu Arg Leu Phe His Lys Leu Phe Ser His Tyr Asn Gln Phe 
        35                  40                  45              


Ile Arg Pro Val Glu Asn Val Ser Asp Pro Val Xaa Val His Phe Glu 
    50                  55                  60                  


Val Ala Ile Xaa Gln Leu Ala Asn Val Ile Trp Asn Asp Tyr Lys Leu 
65                  70                  75                  80  


Arg Trp Asp Pro Met Glu Tyr Asp Gly Ile Glu Xaa Leu Arg Val Pro 
                85                  90                  95      


Ala Asp Lys Ile Trp Lys Pro Asp Ile Val Leu Tyr Asn Asn Ala Val 
            100                 105                 110         


Gly Asp Phe Gln Val Glu Gly Lys Xaa Lys Ala Leu Leu Lys Tyr Asn 
        115                 120                 125             


Gly Met Ile Xaa Trp Xaa Pro Pro Ala Ile Phe Lys Ser Ser Cys Pro 
    130                 135                 140                 


Met Asp Ile Xaa Phe Phe Pro Phe Asp His Gln Asn Cys Ser Leu Lys 
145                 150                 155                 160 


Phe Gly Ser Trp Xaa Tyr Asp Lys Ala Glu Ile Asp Leu Leu Ile Ile 
                165                 170                 175     


Gly Ser Lys Val Asp Met Asn Asp Phe Trp Glu Asn Ser Glu Trp Glu 
            180                 185                 190         


Ile Ile Asp Ala Ser Gly Tyr Lys His Asp Ile Lys Tyr Asn Cys Cys 
        195                 200                 205             


Glu Glu Ile Tyr Xaa Asp Ile Xaa Tyr Ser Phe Tyr Ile Arg Arg Leu 
    210                 215                 220                 


Pro Met Phe Tyr Xaa Ile Asn Leu Ile Ile Pro Cys Leu Phe Ile Ser 
225                 230                 235                 240 


Phe Leu Xaa Val Leu Val Phe Tyr Leu Pro Ser Asp Cys Gly Glu Lys 
                245                 250                 255     


Val Xaa Leu Cys Ile Ser Val Leu Leu Ser Leu Xaa Val Phe Leu Leu 
            260                 265                 270         


Val Ile Xaa Glu Xaa Ile Pro Ser Xaa Ser Leu Val Val Pro Leu Val 
        275                 280                 285             


Gly Glu Tyr Leu Leu Phe Xaa Met Ile Phe Val Xaa Leu Ser Ile Val 
    290                 295                 300                 


Val Xaa Val Phe Val Leu Asn Ile His Tyr Arg Xaa Pro Xaa Xaa His 
305                 310                 315                 320 


Xaa Met Pro Arg Trp Val Lys Xaa Val Phe Leu Lys Leu Leu Pro Gln 
                325                 330                 335     


Val Leu Leu Met Arg Trp Pro Leu Asp Lys Xaa Arg Gly Xaa Gly Ser 
            340                 345                 350         


Asp Ala Val Pro Arg Gly Leu Ala Arg Arg Pro Ala Lys Gly Lys Leu 
        355                 360                 365             


Ala Ser His Gly Glu Pro Arg His Leu Lys Glu Cys Phe His Cys His 
    370                 375                 380                 


Lys Ser Asn Glu Leu Ala Xaa Ser Lys Arg Arg Leu Ser His Gln Pro 
385                 390                 395                 400 


Leu Gln Trp Val Val Glu Asn Ser Glu His Ser Pro Glu Val Glu Asp 
                405                 410                 415     


Val Ile Asn Ser Val Gln Phe Ile Ala Glu Asn Met Lys Ser His Asn 
            420                 425                 430         


Glu Xaa Lys Glu Val Glu Asp Asp Trp Lys Tyr Val Ala Met Val Val 
        435                 440                 445             


Asp Arg Val Phe Leu Trp Val Phe Ile Ile Val Cys Val Phe Gly Xaa 
    450                 455                 460                 


Ala Gly Leu Phe Leu Gln Pro Leu Leu Gly Asn Xaa Gly Lys Ser 
465                 470                 475                 


<210> 6175
<211> 292
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<400> 6175
Ala Ser Pro Pro Ser Xaa Pro Pro Trp Asp Pro Gly His Ile Pro Gly 
1               5                   10                  15      


Ala Ser Val Arg Pro Ala Pro Gly Pro Val Ser Leu Gln Gly Glu Phe 
            20                  25                  30          


Gln Arg Lys Leu Tyr Lys Glu Leu Val Lys Asn Tyr Asn Pro Leu Glu 
        35                  40                  45              


Arg Pro Val Ala Asn Asp Ser Gln Pro Leu Xaa Val Tyr Phe Ser Leu 
    50                  55                  60                  


Ser Leu Leu Gln Ile Met Asp Val Asp Glu Lys Asn Gln Val Leu Xaa 
65                  70                  75                  80  


Xaa Asn Ile Trp Leu Gln Met Ser Trp Xaa Asp His Tyr Leu Gln Trp 
                85                  90                  95      


Asn Val Ser Glu Tyr Pro Gly Val Lys Xaa Val Arg Phe Pro Asp Gly 
            100                 105                 110         


Gln Ile Trp Lys Pro Asp Ile Leu Leu Tyr Asn Ser Ala Asp Glu Arg 
        115                 120                 125             


Phe Asp Ala Xaa Phe His Xaa Asn Val Leu Val Asn Ser Ser Gly His 
    130                 135                 140                 


Cys Gln Tyr Leu Pro Pro Gly Ile Phe Lys Ser Ser Cys Tyr Ile Asp 
145                 150                 155                 160 


Val Arg Trp Phe Pro Phe Asp Val Gln His Cys Lys Leu Lys Phe Gly 
                165                 170                 175     


Ser Trp Ser Tyr Gly Gly Trp Ser Leu Asp Leu Gln Met Gln Glu Ala 
            180                 185                 190         


Asp Ile Ser Gly Tyr Ile Pro Asn Gly Glu Trp Asp Leu Val Val Xaa 
        195                 200                 205             


Met Arg Arg Arg Xaa Leu Tyr Tyr Gly Leu Asn Leu Leu Ile Pro Cys 
    210                 215                 220                 


Val Leu Ile Ser Ala Leu Ala Leu Leu Val Phe Leu Leu Pro Ala Asp 
225                 230                 235                 240 


Ser Gly Glu Lys Ile Ser Leu Gly Ile Xaa Val Leu Leu Ser Leu Xaa 
                245                 250                 255     


Val Phe Met Leu Leu Val Ala Glu Ile Met Pro Ala Xaa Ser Asp Ser 
            260                 265                 270         


Val Pro Leu Ile Ala Gln Tyr Phe Ala Ser Xaa Met Ile Ile Val Gly 
        275                 280                 285             


Leu Ser Val Val 
    290         


<210> 6176
<211> 440
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<400> 6176
Met Asp Val Asp Glu Lys Asn Gln Val Leu Xaa Xaa Asn Ile Trp Leu 
1               5                   10                  15      


Gln Met Ser Trp Xaa Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr 
            20                  25                  30          


Pro Gly Val Lys Xaa Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro 
        35                  40                  45              


Asp Ile Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Xaa Phe 
    50                  55                  60                  


His Xaa Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro 
65                  70                  75                  80  


Pro Gly Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro 
                85                  90                  95      


Phe Asp Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly 
            100                 105                 110         


Gly Trp Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr 
        115                 120                 125             


Ile Pro Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser 
    130                 135                 140                 


Glu Arg Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Xaa Phe 
145                 150                 155                 160 


Xaa Val Xaa Met Arg Arg Arg Xaa Leu Tyr Tyr Gly Leu Asn Leu Leu 
                165                 170                 175     


Ile Pro Cys Val Leu Ile Ser Ala Leu Ala Leu Leu Val Phe Leu Leu 
            180                 185                 190         


Pro Ala Asp Ser Gly Glu Lys Ile Ser Leu Gly Ile Xaa Val Leu Leu 
        195                 200                 205             


Ser Leu Xaa Val Phe Met Leu Leu Val Ala Glu Ile Met Pro Ala Xaa 
    210                 215                 220                 


Ser Asp Ser Val Pro Leu Ile Ala Gln Tyr Phe Ala Ser Xaa Met Ile 
225                 230                 235                 240 


Ile Val Gly Leu Ser Val Val Val Xaa Val Ile Val Leu Gln Tyr His 
                245                 250                 255     


His His Asp Pro Asp Gly Gly Lys Met Pro Lys Trp Xaa Arg Val Ile 
            260                 265                 270         


Leu Leu Asn Trp Cys Ala Trp Phe Leu Arg Met Lys Arg Pro Gly Glu 
        275                 280                 285             


Asp Lys Val Arg Pro Ala Cys Gln His Lys Gln Arg Arg Cys Ser Leu 
    290                 295                 300                 


Ala Ser Val Glu Met Ser Ala Val Ala Pro Pro Pro Ala Ser Asn Gly 
305                 310                 315                 320 


Asn Leu Leu Tyr Ile Gly Phe Arg Gly Leu Asp Gly Val His Cys Val 
                325                 330                 335     


Pro Xaa Pro Asp Ser Gly Val Val Cys Gly Arg Met Ala Cys Ser Pro 
            340                 345                 350         


Xaa His Asp Glu His Leu Leu His Gly Gly Gln Pro Pro Glu Gly Asp 
        355                 360                 365             


Pro Asp Leu Ala Lys Ile Leu Glu Glu Val Arg Tyr Ile Ala Asn Arg 
    370                 375                 380                 


Phe Arg Cys Gln Asp Glu Ser Glu Ala Val Cys Ser Glu Trp Lys Phe 
385                 390                 395                 400 


Ala Ala Cys Val Val Asp Arg Leu Cys Leu Met Ala Phe Ser Val Phe 
                405                 410                 415     


Xaa Ile Ile Cys Xaa Ile Gly Ile Leu Met Ser Ala Pro Asn Phe Val 
            420                 425                 430         


Glu Ala Val Ser Lys Asp Phe Ala 
        435                 440 


<210> 6177
<211> 318
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<400> 6177
Met Asp Val Asp Glu Lys Asn Gln Val Leu Xaa Xaa Asn Ile Trp Leu 
1               5                   10                  15      


Gln Met Ser Trp Xaa Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr 
            20                  25                  30          


Pro Gly Val Lys Xaa Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro 
        35                  40                  45              


Asp Ile Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Xaa Phe 
    50                  55                  60                  


His Xaa Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro 
65                  70                  75                  80  


Pro Gly Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro 
                85                  90                  95      


Phe Asp Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly 
            100                 105                 110         


Gly Trp Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr 
        115                 120                 125             


Ile Pro Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser 
    130                 135                 140                 


Glu Arg Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Xaa Phe 
145                 150                 155                 160 


Xaa Val Xaa Met Arg Arg Arg Xaa Leu Tyr Tyr Gly Leu Asn Leu Leu 
                165                 170                 175     


Ile Pro Cys Val Leu Ile Ser Ala Leu Ala Leu Leu Val Phe Leu Leu 
            180                 185                 190         


Pro Ala Asp Ser Gly Glu Lys Ile Ser Leu Gly Ile Xaa Val Leu Leu 
        195                 200                 205             


Ser Leu Xaa Val Phe Met Leu Leu Val Ala Glu Ile Met Pro Ala Xaa 
    210                 215                 220                 


Ser Asp Ser Val Pro Leu Ile Asp Gln Ser His Pro Ser Glu Leu Val 
225                 230                 235                 240 


Arg Val Val Pro Ala Asn Glu Glu Ala Arg Gly Gly Gln Gly Ala Pro 
                245                 250                 255     


Gly Leu Pro Ala Gln Ala Ala Ala Leu Gln Pro Gly Gln Cys Gly Asp 
            260                 265                 270         


Glu Arg Arg Gly Ala Ala Ala Arg Gln Gln Arg Glu Pro Ala Val His 
        275                 280                 285             


Arg Leu Pro Arg Pro Gly Arg Arg Ala Leu Cys Pro Asp Pro Arg Leu 
    290                 295                 300                 


Trp Gly Ser Val Trp Pro His Gly Leu Leu Pro His Ala Arg 
305                 310                 315             


<210> 6178
<211> 222
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<400> 6178
Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro Asn Gly Glu Trp Asp 
1               5                   10                  15      


Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg Phe Tyr Glu Cys Cys 
            20                  25                  30          


Lys Glu Pro Tyr Pro Asp Val Xaa Phe Xaa Val Xaa Met Arg Arg Arg 
        35                  40                  45              


Xaa Leu Tyr Tyr Gly Leu Asn Leu Leu Ile Pro Cys Val Leu Ile Ser 
    50                  55                  60                  


Ala Leu Ala Leu Leu Val Phe Leu Leu Pro Ala Asp Ser Gly Glu Lys 
65                  70                  75                  80  


Ile Ser Leu Gly Ile Xaa Val Leu Leu Ser Leu Xaa Val Phe Met Leu 
                85                  90                  95      


Leu Val Ala Glu Ile Met Pro Ala Xaa Ser Asp Ser Val Pro Leu Ile 
            100                 105                 110         


Ala Gln Tyr Phe Ala Ser Xaa Met Ile Ile Val Gly Leu Ser Val Val 
        115                 120                 125             


Val Xaa Val Ile Val Leu Gln Tyr His His His Asp Pro Asp Gly Gly 
    130                 135                 140                 


Lys Met Pro Lys Trp Xaa Arg Val Ile Leu Leu Asn Trp Cys Ala Trp 
145                 150                 155                 160 


Phe Leu Arg Met Lys Arg Pro Gly Glu Asp Lys Val Arg Pro Ala Cys 
                165                 170                 175     


Gln His Lys Gln Arg Arg Cys Ser Leu Ala Ser Val Glu Met Ser Ala 
            180                 185                 190         


Val Ala Pro Pro Pro Ala Ser Asn Gly Asn Leu Leu Tyr Ile Gly Phe 
        195                 200                 205             


Arg Gly Leu Asp Gly Val His Cys Val Pro Xaa Pro Asp Ser 
    210                 215                 220         


<210> 6179
<211> 531
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<400> 6179
Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Gly Lys Ala Xaa Ala Ser Pro Pro Ser Xaa Pro Pro Trp Asp 
            20                  25                  30          


Pro Gly His Ile Pro Gly Ala Ser Val Arg Pro Ala Pro Gly Pro Val 
        35                  40                  45              


Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu Leu Val Lys 
    50                  55                  60                  


Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser Gln Pro Leu 
65                  70                  75                  80  


Xaa Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp Val Asp Glu 
                85                  90                  95      


Lys Asn Gln Val Leu Xaa Xaa Asn Ile Trp Leu Gln Met Ser Trp Xaa 
            100                 105                 110         


Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly Val Lys Xaa 
        115                 120                 125             


Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile Leu Leu Tyr 
    130                 135                 140                 


Asn Ser Ala Asp Glu Arg Phe Asp Ala Xaa Phe His Xaa Asn Val Leu 
145                 150                 155                 160 


Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly Ile Phe Lys 
                165                 170                 175     


Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp Val Gln His 
            180                 185                 190         


Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp Ser Leu Asp 
        195                 200                 205             


Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro Asn Gly Glu 
    210                 215                 220                 


Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg Phe Tyr Glu 
225                 230                 235                 240 


Cys Cys Lys Glu Pro Tyr Pro Asp Val Xaa Phe Xaa Val Xaa Met Arg 
                245                 250                 255     


Arg Arg Xaa Leu Tyr Tyr Gly Leu Asn Leu Leu Ile Pro Cys Val Leu 
            260                 265                 270         


Ile Ser Ala Leu Ala Leu Leu Val Phe Leu Leu Pro Ala Asp Ser Gly 
        275                 280                 285             


Glu Lys Ile Ser Leu Gly Ile Xaa Val Leu Leu Ser Leu Xaa Val Phe 
    290                 295                 300                 


Met Leu Leu Val Ala Glu Ile Met Pro Ala Xaa Ser Asp Ser Val Pro 
305                 310                 315                 320 


Leu Ile Ala Gln Tyr Phe Ala Ser Xaa Met Ile Ile Val Gly Leu Ser 
                325                 330                 335     


Val Val Val Xaa Val Ile Val Leu Gln Tyr His His His Asp Pro Asp 
            340                 345                 350         


Gly Gly Lys Met Pro Lys Trp Xaa Arg Val Ile Leu Leu Asn Trp Cys 
        355                 360                 365             


Ala Trp Phe Leu Arg Met Lys Arg Pro Gly Glu Asp Lys Val Arg Pro 
    370                 375                 380                 


Ala Cys Gln His Lys Gln Arg Arg Cys Ser Leu Ala Ser Val Glu Met 
385                 390                 395                 400 


Ser Ala Val Ala Pro Pro Pro Ala Ser Asn Gly Asn Leu Leu Tyr Ile 
                405                 410                 415     


Gly Phe Arg Gly Leu Asp Gly Val His Cys Val Pro Xaa Pro Asp Ser 
            420                 425                 430         


Gly Val Val Cys Gly Arg Met Ala Cys Ser Pro Xaa His Asp Glu His 
        435                 440                 445             


Leu Leu His Gly Gly Gln Pro Pro Glu Gly Asp Pro Asp Leu Ala Lys 
    450                 455                 460                 


Ile Leu Glu Glu Val Arg Tyr Ile Ala Asn Arg Phe Arg Cys Gln Asp 
465                 470                 475                 480 


Glu Ser Glu Ala Val Cys Ser Glu Trp Lys Phe Ala Ala Cys Val Val 
                485                 490                 495     


Asp Arg Leu Cys Leu Met Ala Phe Ser Val Phe Xaa Ile Ile Cys Xaa 
            500                 505                 510         


Ile Gly Ile Leu Met Ser Ala Pro Asn Phe Val Glu Ala Val Ser Lys 
        515                 520                 525             


Asp Phe Ala 
    530     


<210> 6180
<211> 102
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<400> 6180
Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Xaa Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Xaa Xaa Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ala Tyr Ser Arg Val Pro Ala Xaa Ser Met Tyr Ala Gly Phe Pro Leu 
                85                  90                  95      


Met Cys Ser Xaa Ala Asn 
            100         


<210> 6181
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<400> 6181
Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Xaa Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Xaa Xaa Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Cys 
    


<210> 6182
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<400> 6182
Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Xaa Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Xaa Xaa Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ile Xaa Ile Tyr Ser Gly Met Cys Gln Asn Ile Gln Gly 
                85                  90              


<210> 6183
<211> 132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 6183
Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Xaa Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Xaa Xaa Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Xaa Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Xaa Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Arg His Ile Gln Glu Phe Leu Leu His Arg Cys Xaa 
        115                 120                 125             


Leu Val Ser Leu 
    130         


<210> 6184
<211> 502
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<400> 6184
Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Xaa Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Xaa Xaa Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Xaa Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Xaa Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Xaa Phe His Xaa 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
145                 150                 155                 160 


Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Xaa Phe Xaa Val 
    210                 215                 220                 


Xaa Met Arg Arg Arg Xaa Leu Tyr Tyr Gly Leu Asn Leu Leu Ile Pro 
225                 230                 235                 240 


Cys Val Leu Ile Ser Ala Leu Ala Leu Leu Val Phe Leu Leu Pro Ala 
                245                 250                 255     


Asp Ser Gly Glu Lys Ile Ser Leu Gly Ile Xaa Val Leu Leu Ser Leu 
            260                 265                 270         


Xaa Val Phe Met Leu Leu Val Ala Glu Ile Met Pro Ala Xaa Ser Asp 
        275                 280                 285             


Ser Val Pro Leu Ile Ala Gln Tyr Phe Ala Ser Xaa Met Ile Ile Val 
    290                 295                 300                 


Gly Leu Ser Val Val Val Xaa Val Ile Val Leu Gln Tyr His His His 
305                 310                 315                 320 


Asp Pro Asp Gly Gly Lys Met Pro Lys Trp Xaa Arg Val Ile Leu Leu 
                325                 330                 335     


Asn Trp Cys Ala Trp Phe Leu Arg Met Lys Arg Pro Gly Glu Asp Lys 
            340                 345                 350         


Val Arg Pro Ala Cys Gln His Lys Gln Arg Arg Cys Ser Leu Ala Ser 
        355                 360                 365             


Val Glu Met Ser Ala Val Ala Pro Pro Pro Ala Ser Asn Gly Asn Leu 
    370                 375                 380                 


Leu Tyr Ile Gly Phe Arg Gly Leu Asp Gly Val His Cys Val Pro Xaa 
385                 390                 395                 400 


Pro Asp Ser Gly Val Val Cys Gly Arg Met Ala Cys Ser Pro Xaa His 
                405                 410                 415     


Asp Glu His Leu Leu His Gly Gly Gln Pro Pro Glu Gly Asp Pro Asp 
            420                 425                 430         


Leu Ala Lys Ile Leu Glu Glu Val Arg Tyr Ile Ala Asn Arg Phe Arg 
        435                 440                 445             


Cys Gln Asp Glu Ser Glu Ala Val Cys Ser Glu Trp Lys Phe Ala Ala 
    450                 455                 460                 


Cys Val Val Asp Arg Leu Cys Leu Met Ala Phe Ser Val Phe Xaa Ile 
465                 470                 475                 480 


Ile Cys Xaa Ile Gly Ile Leu Met Ser Ala Pro Asn Phe Val Glu Ala 
                485                 490                 495     


Val Ser Lys Asp Phe Ala 
            500         


<210> 6185
<211> 285
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<400> 6185
Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Xaa Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Xaa Xaa Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Xaa Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Xaa Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Xaa Phe His Xaa 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
145                 150                 155                 160 


Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Val Xaa Met Arg Arg Arg Xaa Leu Tyr 
        195                 200                 205             


Tyr Gly Leu Asn Leu Leu Ile Pro Cys Val Leu Ile Ser Ala Leu Ala 
    210                 215                 220                 


Leu Leu Val Phe Leu Leu Pro Ala Asp Ser Gly Glu Lys Ile Ser Leu 
225                 230                 235                 240 


Gly Ile Xaa Val Leu Leu Ser Leu Xaa Val Phe Met Leu Leu Val Ala 
                245                 250                 255     


Glu Ile Met Pro Ala Xaa Ser Asp Ser Val Pro Leu Ile Ala Gln Tyr 
            260                 265                 270         


Phe Ala Ser Xaa Met Ile Ile Val Gly Leu Ser Val Val 
        275                 280                 285 


<210> 6186
<211> 160
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<400> 6186
Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Xaa Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Xaa Xaa Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Xaa Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Xaa Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ser Tyr Asp Gln Gln Gln Glu Val Leu Ala Tyr 
        115                 120                 125             


Gly Met His Cys Trp Ser Pro Gln Phe Gly Pro Xaa Ser Ser Ser Met 
    130                 135                 140                 


Phe Pro Val Val His Trp Arg Val Leu Trp Gln Arg Trp Leu Gln Cys 
145                 150                 155                 160 


<210> 6187
<211> 180
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<400> 6187
Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Xaa Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Xaa Xaa Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Xaa Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Xaa Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Tyr Asp Gln Gln Gln Glu Val Leu Ala Tyr Gly 
        115                 120                 125             


Met His Cys Trp Ser Pro Gln Phe Gly Pro Xaa Ser Ser Ser Met Phe 
    130                 135                 140                 


Pro Val Val His Trp Arg Val Leu Trp Gln Arg Trp Leu Gln Ala Tyr 
145                 150                 155                 160 


Ser Arg Val Pro Ala Xaa Ser Met Tyr Ala Gly Phe Pro Leu Met Cys 
                165                 170                 175     


Ser Xaa Ala Asn 
            180 


<210> 6188
<211> 159
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<400> 6188
Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Xaa Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Xaa Xaa Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Xaa Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Xaa Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Tyr Asp Gln Gln Gln Glu Val Leu Ala Tyr Gly 
        115                 120                 125             


Met His Cys Trp Ser Pro Gln Phe Gly Pro Xaa Ser Ser Ser Met Phe 
    130                 135                 140                 


Pro Val Val His Trp Arg Val Leu Trp Gln Arg Trp Leu Gln Cys 
145                 150                 155                 


<210> 6189
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<400> 6189
Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Xaa Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Ile Leu Arg Ile Asn Lys Lys Xaa Asp Ser Ile Cys Ser Gly Leu 
65                  70                  75                  80  


Cys 
    


<210> 6190
<211> 210
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<400> 6190
Met Ser Trp Xaa Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro 
1               5                   10                  15      


Gly Val Lys Xaa Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp 
            20                  25                  30          


Ile Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Xaa Phe His 
        35                  40                  45              


Xaa Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro 
    50                  55                  60                  


Gly Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe 
65                  70                  75                  80  


Asp Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly 
                85                  90                  95      


Trp Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile 
            100                 105                 110         


Pro Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu 
        115                 120                 125             


Arg Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Xaa Phe Xaa 
    130                 135                 140                 


Val Xaa Met Arg Arg Arg Xaa Leu Tyr Tyr Gly Leu Asn Leu Leu Ile 
145                 150                 155                 160 


Pro Cys Val Leu Ile Ser Ala Leu Ala Leu Leu Val Phe Leu Leu Pro 
                165                 170                 175     


Ala Asp Ser Gly Glu Lys Ile Ser Leu Gly Ile Xaa Val Leu Leu Ser 
            180                 185                 190         


Leu Xaa Val Phe Met Leu Leu Val Ala Glu Ile Met Pro Ala Xaa Ser 
        195                 200                 205             


Asp Ser 
    210 


<210> 6191
<211> 423
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<400> 6191
Met Ser Trp Xaa Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro 
1               5                   10                  15      


Gly Val Lys Xaa Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp 
            20                  25                  30          


Ile Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Xaa Phe His 
        35                  40                  45              


Xaa Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro 
    50                  55                  60                  


Gly Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe 
65                  70                  75                  80  


Asp Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly 
                85                  90                  95      


Trp Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile 
            100                 105                 110         


Pro Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu 
        115                 120                 125             


Arg Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Xaa Phe Xaa 
    130                 135                 140                 


Val Xaa Met Arg Arg Arg Xaa Leu Tyr Tyr Gly Leu Asn Leu Leu Ile 
145                 150                 155                 160 


Pro Cys Val Leu Ile Ser Ala Leu Ala Leu Leu Val Phe Leu Leu Pro 
                165                 170                 175     


Ala Asp Ser Gly Glu Lys Ile Ser Leu Gly Ile Xaa Val Leu Leu Ser 
            180                 185                 190         


Leu Xaa Val Phe Met Leu Leu Val Ala Glu Ile Met Pro Ala Xaa Ser 
        195                 200                 205             


Asp Ser Val Pro Leu Ile Ala Gln Tyr Phe Ala Ser Xaa Met Ile Ile 
    210                 215                 220                 


Val Gly Leu Ser Val Val Val Xaa Val Ile Val Leu Gln Tyr His His 
225                 230                 235                 240 


His Asp Pro Asp Gly Gly Lys Met Pro Lys Trp Xaa Arg Val Ile Leu 
                245                 250                 255     


Leu Asn Trp Cys Ala Trp Phe Leu Arg Met Lys Arg Pro Gly Glu Asp 
            260                 265                 270         


Lys Val Arg Pro Ala Cys Gln His Lys Gln Arg Arg Cys Ser Leu Ala 
        275                 280                 285             


Ser Val Glu Met Ser Ala Val Ala Pro Pro Pro Ala Ser Asn Gly Asn 
    290                 295                 300                 


Leu Leu Tyr Ile Gly Phe Arg Gly Leu Asp Gly Val His Cys Val Pro 
305                 310                 315                 320 


Xaa Pro Asp Ser Gly Val Val Cys Gly Arg Met Ala Cys Ser Pro Xaa 
                325                 330                 335     


His Asp Glu His Leu Leu His Gly Gly Gln Pro Pro Glu Gly Asp Pro 
            340                 345                 350         


Asp Leu Ala Lys Ile Leu Glu Glu Val Arg Tyr Ile Ala Asn Arg Phe 
        355                 360                 365             


Arg Cys Gln Asp Glu Ser Glu Ala Val Cys Ser Glu Trp Lys Phe Ala 
    370                 375                 380                 


Ala Cys Val Val Asp Arg Leu Cys Leu Met Ala Phe Ser Val Phe Xaa 
385                 390                 395                 400 


Ile Ile Cys Xaa Ile Gly Ile Leu Met Ser Ala Pro Asn Phe Val Glu 
                405                 410                 415     


Ala Val Ser Lys Asp Phe Ala 
            420             


<210> 6192
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<400> 6192
Arg Arg Xaa Leu Tyr Tyr Gly Leu Asn Leu Leu Ile Pro Cys Val Leu 
1               5                   10                  15      


Ile Ser Ala Leu Ala Leu Leu Val Phe Leu Leu Pro Ala Asp Ser Gly 
            20                  25                  30          


Glu Lys Ile Ser Leu Gly Ile Xaa Val Leu Leu Ser Leu Xaa Val Phe 
        35                  40                  45              


Met Leu Leu Val Ala Glu Ile Met Pro Ala Xaa Ser Asp Ser Val Pro 
    50                  55                  60                  


Leu Ile Ala His Cys Phe Gln 
65                  70      


<210> 6193
<211> 231
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<400> 6193
Xaa Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
1               5                   10                  15      


Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
            20                  25                  30          


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
        35                  40                  45              


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
    50                  55                  60                  


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Xaa Phe Xaa Val 
65                  70                  75                  80  


Xaa Met Arg Arg Arg Xaa Leu Tyr Tyr Gly Leu Asn Leu Leu Ile Pro 
                85                  90                  95      


Cys Val Leu Ile Ser Ala Leu Ala Leu Leu Val Phe Leu Leu Pro Ala 
            100                 105                 110         


Asp Ser Gly Glu Lys Ile Ser Leu Ala Gln Tyr Phe Ala Ser Xaa Met 
        115                 120                 125             


Ile Ile Val Gly Leu Ser Val Val Val Xaa Val Ile Val Leu Gln Tyr 
    130                 135                 140                 


His His His Asp Pro Asp Gly Gly Lys Met Pro Lys Trp Xaa Arg Val 
145                 150                 155                 160 


Ile Leu Leu Asn Trp Cys Ala Trp Phe Leu Arg Met Lys Arg Pro Gly 
                165                 170                 175     


Glu Asp Lys Val Arg Pro Ala Cys Gln His Lys Gln Arg Arg Cys Ser 
            180                 185                 190         


Leu Ala Ser Val Glu Met Ser Ala Val Ala Pro Pro Pro Ala Ser Asn 
        195                 200                 205             


Gly Asn Leu Leu Tyr Ile Gly Phe Arg Gly Leu Asp Gly Val His Cys 
    210                 215                 220                 


Val Pro Xaa Pro Asp Ser Gly 
225                 230     


<210> 6194
<211> 84
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<400> 6194
Xaa Gly Glu Lys Ile Ser Leu Gly Ile Xaa Val Leu Leu Ser Leu Xaa 
1               5                   10                  15      


Val Phe Met Leu Leu Val Ala Glu Ile Met Pro Ala Xaa Ser Asp Ser 
            20                  25                  30          


Val Pro Leu Ile Ala Gln Tyr Phe Ala Ser Xaa Met Ile Ile Val Gly 
        35                  40                  45              


Leu Ser Val Val Val Xaa Val Ile Val Leu Gln Tyr His His His Asp 
    50                  55                  60                  


Pro Asp Gly Gly Lys Met Pro Lys Trp Pro Pro Arg Asp Phe Tyr Tyr 
65                  70                  75                  80  


Asp Leu Leu Leu 
                


<210> 6195
<211> 40
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(30)
<223> Selenocysteine

<400> 6195
Xaa Asn Asp Ser Gln Pro Leu Xaa Val Tyr Phe Ser Leu Ser Leu Leu 
1               5                   10                  15      


Gln Ile Met Asp Val Asp Glu Lys Asn Gln Val Leu Xaa Xaa Asn Ile 
            20                  25                  30          


Trp Leu Gln Met Asn Ile Gln Gly 
        35                  40  


<210> 6196
<211> 302
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<400> 6196
Xaa Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp Val Asp Glu Lys 
1               5                   10                  15      


Asn Gln Val Leu Xaa Xaa Asn Ile Trp Leu Gln Met Ser Trp Xaa Asp 
            20                  25                  30          


His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly Val Lys Xaa Val 
        35                  40                  45              


Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile Leu Leu Tyr Asn 
    50                  55                  60                  


Ser Ala Asp Glu Arg Phe Asp Ala Xaa Phe His Xaa Asn Val Leu Val 
65                  70                  75                  80  


Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly Ile Phe Lys Ser 
                85                  90                  95      


Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp Val Gln His Cys 
            100                 105                 110         


Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp Ser Leu Asp Leu 
        115                 120                 125             


Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro Asn Gly Glu Trp 
    130                 135                 140                 


Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg Phe Tyr Glu Cys 
145                 150                 155                 160 


Cys Lys Glu Pro Tyr Pro Asp Val Xaa Phe Xaa Val Xaa Met Arg Arg 
                165                 170                 175     


Arg Xaa Leu Tyr Tyr Gly Leu Asn Leu Leu Ile Pro Cys Val Leu Ile 
            180                 185                 190         


Ser Ala Leu Ala Leu Leu Val Phe Leu Leu Pro Ala Asp Ser Gly Glu 
        195                 200                 205             


Lys Ile Ser Leu Gly Ile Xaa Val Leu Leu Ser Leu Xaa Val Phe Met 
    210                 215                 220                 


Leu Leu Val Ala Glu Ile Met Pro Ala Xaa Ser Asp Ser Val Pro Leu 
225                 230                 235                 240 


Ile Ala Gln Tyr Phe Ala Ser Xaa Met Ile Ile Val Gly Leu Ser Val 
                245                 250                 255     


Val Val Xaa Val Ile Val Leu Gln Tyr His His His Asp Pro Asp Gly 
            260                 265                 270         


Gly Lys Met Pro Lys Trp Gly Xaa Leu Lys Asn Ser Phe Ala Lys Trp 
        275                 280                 285             


Ser Arg His His Lys Arg Cys Gly Asn Leu Met Leu Glu Ala 
    290                 295                 300         


<210> 6197
<211> 479
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<400> 6197
Met Asn Trp Ser His Ser Cys Ile Ser Phe Cys Trp Ile Tyr Phe Ala 
1               5                   10                  15      


Ala Ser Arg Leu Arg Ala Ala Glu Xaa Ala Asp Gly Lys Tyr Ala Gln 
            20                  25                  30          


Lys Leu Phe Asn Asp Leu Phe Glu Asp Tyr Ser Asn Ala Leu Arg Pro 
        35                  40                  45              


Val Glu Asp Xaa Asp Lys Val Leu Asn Val Xaa Leu Gln Ile Xaa Leu 
    50                  55                  60                  


Ser Gln Ile Lys Asp Met Asp Glu Arg Asn Gln Ile Leu Xaa Ala Tyr 
65                  70                  75                  80  


Leu Trp Ile Arg Gln Ile Trp His Asp Ala Tyr Leu Xaa Trp Asp Arg 
                85                  90                  95      


Asp Gln Tyr Asp Gly Leu Asp Ser Ile Arg Ile Pro Ser Asp Leu Val 
            100                 105                 110         


Trp Arg Pro Asp Ile Val Leu Tyr Asn Lys Ala Asp Asp Glu Ser Ser 
        115                 120                 125             


Glu Pro Val Asn Xaa Asn Val Val Leu Arg Tyr Asp Gly Leu Ile Xaa 
    130                 135                 140                 


Trp Asp Ala Pro Ala Ile Xaa Lys Ser Ser Cys Val Val Asp Val Xaa 
145                 150                 155                 160 


Tyr Phe Pro Phe Asp Asn Gln Gln Cys Asn Leu Xaa Phe Gly Ser Trp 
                165                 170                 175     


Xaa Tyr Asn Gly Asn Gln Val Asp Ile Phe Asn Ala Leu Asp Ser Gly 
            180                 185                 190         


Asp Leu Ser Asp Phe Ile Glu Asp Val Glu Trp Glu Val His Gly Met 
        195                 200                 205             


Pro Ala Val Lys Asn Val Ile Ser Tyr Gly Cys Cys Ser Glu Pro Tyr 
    210                 215                 220                 


Pro Asp Val Xaa Phe Xaa Leu Leu Leu Lys Arg Arg Ser Ser Phe Tyr 
225                 230                 235                 240 


Ile Val Asn Leu Leu Ile Pro Cys Val Leu Ile Ser Phe Leu Ala Pro 
                245                 250                 255     


Leu Ser Phe Tyr Leu Pro Ala Ala Ser Gly Glu Lys Val Ser Leu Gly 
            260                 265                 270         


Val Xaa Ile Leu Leu Ala Met Xaa Val Phe Gln Leu Met Val Ala Glu 
        275                 280                 285             


Ile Met Pro Ala Ser Glu Asn Val Pro Leu Ile Gly Lys Tyr Tyr Ile 
    290                 295                 300                 


Ala Xaa Met Ala Leu Ile Xaa Ala Ser Xaa Ala Leu Xaa Ile Met Val 
305                 310                 315                 320 


Met Asn Ile His Phe Cys Gly Ala Glu Ala Arg Pro Val Pro His Trp 
                325                 330                 335     


Ala Arg Val Val Ile Leu Lys Tyr Met Ser Arg Val Leu Phe Val Tyr 
            340                 345                 350         


Asp Val Gly Glu Ser Cys Leu Ser Pro His His Ser Arg Glu Arg Asp 
        355                 360                 365             


His Leu Xaa Lys Val Tyr Ser Lys Leu Pro Glu Ser Asn Leu Lys Ala 
    370                 375                 380                 


Ala Arg Asn Lys Asp Leu Ser Arg Lys Lys Asp Met Asn Lys Arg Leu 
385                 390                 395                 400 


Lys Asn Asp Leu Gly Cys Gln Gly Lys Asn Pro Gln Glu Ala Glu Ser 
                405                 410                 415     


Tyr Cys Ala Gln Tyr Lys Val Leu Xaa Arg Asn Ile Glu Tyr Ile Ala 
            420                 425                 430         


Lys Cys Leu Lys Asp His Lys Ala Xaa Asn Ser Lys Gly Ser Glu Trp 
        435                 440                 445             


Lys Lys Val Ala Lys Val Ile Asp Arg Phe Phe Met Trp Ile Phe Phe 
    450                 455                 460                 


Ile Met Val Phe Val Met Xaa Ile Leu Ile Ile Ala Arg Ala Asp 
465                 470                 475                 


<210> 6198
<211> 429
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<400> 6198
Met Ser Xaa Lys Val Tyr Leu Asp Leu Glu Trp Xaa Asp Tyr Arg Leu 
1               5                   10                  15      


Ser Trp Asp Pro Ala Glu His Asp Gly Ile Asp Ser Leu Arg Ile Xaa 
            20                  25                  30          


Ala Glu Ser Val Trp Leu Pro Asp Val Val Leu Leu Asn Asn Asn Asp 
        35                  40                  45              


Gly Asn Phe Asp Val Ala Leu Asp Ile Ser Val Val Val Ser Ser Asp 
    50                  55                  60                  


Gly Ser Val Arg Trp Gln Pro Pro Gly Ile Tyr Arg Ser Ser Cys Ser 
65                  70                  75                  80  


Ile Gln Val Xaa Tyr Phe Pro Phe Asp Trp Gln Asn Cys Xaa Met Val 
                85                  90                  95      


Phe Ser Ser Tyr Ser Tyr Asp Ser Ser Glu Val Ser Leu Gln Xaa Gly 
            100                 105                 110         


Leu Gly Pro Asp Gly Gln Gly His Gln Glu Ile His Ile His Glu Gly 
        115                 120                 125             


Xaa Phe Ile Glu Asn Gly Gln Trp Glu Ile Ile His Lys Pro Ser Arg 
    130                 135                 140                 


Leu Ile Gln Pro Pro Gly Asp Pro Arg Gly Gly Arg Glu Gly Gln Arg 
145                 150                 155                 160 


Gln Glu Val Ile Phe Tyr Leu Ile Ile Arg Arg Lys Pro Leu Phe Tyr 
                165                 170                 175     


Leu Val Asn Val Ile Ala Pro Cys Ile Leu Ile Xaa Leu Leu Ala Ile 
            180                 185                 190         


Phe Val Phe Tyr Leu Pro Pro Asp Ala Gly Glu Lys Met Gly Leu Ser 
        195                 200                 205             


Ile Phe Ala Leu Leu Xaa Leu Xaa Val Phe Leu Leu Leu Leu Ala Asp 
    210                 215                 220                 


Lys Val Pro Glu Xaa Ser Leu Ser Val Pro Ile Ile Ile Lys Tyr Leu 
225                 230                 235                 240 


Met Phe Xaa Met Val Leu Val Xaa Phe Ser Val Ile Leu Ser Val Val 
                245                 250                 255     


Val Leu Asn Leu His His Arg Ser Pro His Xaa His Gln Met Pro Leu 
            260                 265                 270         


Trp Val Arg Gln Ile Phe Ile His Lys Leu Pro Leu Tyr Leu Arg Leu 
        275                 280                 285             


Lys Arg Pro Lys Pro Glu Arg Asp Leu Met Pro Glu Pro Pro His Cys 
    290                 295                 300                 


Ser Ser Pro Gly Ser Gly Trp Gly Arg Gly Xaa Asp Glu Tyr Phe Ile 
305                 310                 315                 320 


Arg Lys Pro Pro Ser Asp Phe Leu Phe Pro Lys Pro Asn Arg Phe Gln 
                325                 330                 335     


Pro Glu Leu Ser Ala Pro Asp Leu Arg Arg Phe Ile Asp Gly Pro Asn 
            340                 345                 350         


Arg Ala Val Ala Leu Leu Pro Glu Leu Arg Glu Val Val Ser Ser Ile 
        355                 360                 365             


Ser Tyr Ile Ala Arg Gln Leu Gln Glu Gln Glu Asp His Asp Ala Leu 
    370                 375                 380                 


Lys Glu Asp Trp Gln Phe Val Ala Met Val Val Asp Arg Leu Phe Leu 
385                 390                 395                 400 


Trp Xaa Phe Ile Ile Phe Xaa Ser Val Gly Xaa Leu Val Ile Phe Leu 
                405                 410                 415     


Asp Ala Xaa Tyr His Leu Pro Pro Pro Asp Pro Phe Pro 
            420                 425                 


<210> 6199
<211> 380
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<400> 6199
Met Ser Xaa Lys Val Tyr Leu Asp Leu Glu Trp Xaa Asp Tyr Arg Leu 
1               5                   10                  15      


Ser Trp Asp Pro Ala Glu His Asp Gly Ile Asp Ser Leu Arg Ile Xaa 
            20                  25                  30          


Ala Glu Ser Val Trp Leu Pro Asp Val Val Leu Leu Asn Asn Asn Asp 
        35                  40                  45              


Gly Asn Phe Asp Val Ala Leu Asp Ile Ser Val Val Val Ser Ser Asp 
    50                  55                  60                  


Gly Ser Val Arg Trp Gln Pro Pro Gly Ile Tyr Arg Ser Ser Cys Ser 
65                  70                  75                  80  


Ile Gln Val Xaa Tyr Phe Pro Phe Asp Trp Gln Asn Cys Xaa Met Val 
                85                  90                  95      


Phe Ser Ser Tyr Ser Tyr Asp Ser Ser Glu Val Ser Leu Gln Xaa Gly 
            100                 105                 110         


Leu Gly Pro Asp Gly Gln Gly His Gln Glu Ile His Ile His Glu Gly 
        115                 120                 125             


Xaa Phe Ile Glu Asn Gly Gln Trp Glu Ile Ile His Lys Pro Ser Arg 
    130                 135                 140                 


Leu Ile Gln Pro Pro Gly Asp Pro Arg Gly Gly Arg Glu Gly Gln Arg 
145                 150                 155                 160 


Gln Glu Val Ile Phe Tyr Leu Ile Ile Arg Arg Lys Pro Leu Phe Tyr 
                165                 170                 175     


Leu Val Asn Val Ile Ala Pro Cys Ile Leu Ile Xaa Leu Leu Ala Ile 
            180                 185                 190         


Phe Val Phe Tyr Leu Pro Pro Asp Ala Val Ile Leu Ser Val Val Val 
        195                 200                 205             


Leu Asn Leu His His Arg Ser Pro His Xaa His Gln Met Pro Leu Trp 
    210                 215                 220                 


Val Arg Gln Ile Phe Ile His Lys Leu Pro Leu Tyr Leu Arg Leu Lys 
225                 230                 235                 240 


Arg Pro Lys Pro Glu Arg Asp Leu Met Pro Glu Pro Pro His Cys Ser 
                245                 250                 255     


Ser Pro Gly Ser Gly Trp Gly Arg Gly Xaa Asp Glu Tyr Phe Ile Arg 
            260                 265                 270         


Lys Pro Pro Ser Asp Phe Leu Phe Pro Lys Pro Asn Arg Phe Gln Pro 
        275                 280                 285             


Glu Leu Ser Ala Pro Asp Leu Arg Arg Phe Ile Asp Gly Pro Asn Arg 
    290                 295                 300                 


Ala Val Ala Leu Leu Pro Glu Leu Arg Glu Val Val Ser Ser Ile Ser 
305                 310                 315                 320 


Tyr Ile Ala Arg Gln Leu Gln Glu Gln Glu Asp His Asp Ala Leu Lys 
                325                 330                 335     


Glu Asp Trp Gln Phe Val Ala Met Val Val Asp Arg Leu Phe Leu Trp 
            340                 345                 350         


Xaa Phe Ile Ile Phe Xaa Ser Val Gly Xaa Leu Val Ile Phe Leu Asp 
        355                 360                 365             


Ala Xaa Tyr His Leu Pro Pro Pro Asp Pro Phe Pro 
    370                 375                 380 


<210> 6200
<211> 158
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 6200
Met Xaa Pro Gly Ala Leu Leu Met Leu Leu Gly Ala Leu Gly Ala Pro 
1               5                   10                  15      


Leu Ala Pro Gly Val Arg Gly Ser Glu Ala Glu Gly Arg Leu Arg Glu 
            20                  25                  30          


Lys Leu Phe Ser Gly Tyr Asp Ser Ser Val Arg Pro Ala Arg Glu Val 
        35                  40                  45              


Gly Asp Arg Val Arg Val Ser Val Gly Leu Ile Leu Ala Gln Leu Ile 
    50                  55                  60                  


Ser Leu Asn Glu Lys Asp Glu Glu Met Ser Xaa Lys Val Tyr Leu Asp 
65                  70                  75                  80  


Leu Ala Val Leu Glu Cys Gly Gly Ser Ser His Pro Pro Ala Ser Gly 
                85                  90                  95      


Gly Xaa Ser Xaa Ser Ala Glu Ile Xaa Ala Glu Trp Xaa Asp Tyr Arg 
            100                 105                 110         


Leu Ser Trp Asp Pro Ala Glu His Asp Gly Ile Asp Ser Leu Arg Ile 
        115                 120                 125             


Xaa Ala Glu Ser Val Trp Leu Pro Asp Val Val Leu Leu Asn Asn Asn 
    130                 135                 140                 


Asp Gly Asn Phe Asp Val Ala Leu Asp Ile Ser Val Val Val 
145                 150                 155             


<210> 6201
<211> 501
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<400> 6201
Met Xaa Pro Gly Ala Leu Leu Met Leu Leu Gly Ala Leu Gly Ala Pro 
1               5                   10                  15      


Leu Ala Pro Gly Val Arg Gly Ser Glu Ala Glu Gly Arg Leu Arg Glu 
            20                  25                  30          


Lys Leu Phe Ser Gly Tyr Asp Ser Ser Val Arg Pro Ala Arg Glu Val 
        35                  40                  45              


Gly Asp Arg Val Arg Val Ser Val Gly Leu Ile Leu Ala Gln Leu Ile 
    50                  55                  60                  


Ser Leu Asn Glu Lys Asp Glu Glu Met Ser Xaa Lys Val Tyr Leu Asp 
65                  70                  75                  80  


Leu Glu Trp Xaa Asp Tyr Arg Leu Ser Trp Asp Pro Ala Glu His Asp 
                85                  90                  95      


Gly Ile Asp Ser Leu Arg Ile Xaa Ala Glu Ser Val Trp Leu Pro Asp 
            100                 105                 110         


Val Val Leu Leu Asn Asn Asn Asp Gly Asn Phe Asp Val Ala Leu Asp 
        115                 120                 125             


Ile Ser Val Val Val Ser Ser Asp Gly Ser Val Arg Trp Gln Pro Pro 
    130                 135                 140                 


Gly Ile Tyr Arg Ser Ser Cys Ser Ile Gln Val Xaa Tyr Phe Pro Phe 
145                 150                 155                 160 


Asp Trp Gln Asn Cys Xaa Met Val Phe Ser Ser Tyr Ser Tyr Asp Ser 
                165                 170                 175     


Ser Glu Val Ser Leu Gln Xaa Gly Leu Gly Pro Asp Gly Gln Gly His 
            180                 185                 190         


Gln Glu Ile His Ile His Glu Gly Xaa Phe Ile Glu Asn Gly Gln Trp 
        195                 200                 205             


Glu Ile Ile His Lys Pro Ser Arg Leu Ile Gln Pro Pro Gly Asp Pro 
    210                 215                 220                 


Arg Gly Gly Arg Glu Gly Gln Arg Gln Glu Val Ile Phe Tyr Leu Ile 
225                 230                 235                 240 


Ile Arg Arg Lys Pro Leu Phe Tyr Leu Val Asn Val Ile Ala Pro Cys 
                245                 250                 255     


Ile Leu Ile Xaa Leu Leu Ala Ile Phe Val Phe Tyr Leu Pro Pro Asp 
            260                 265                 270         


Ala Gly Glu Lys Met Gly Leu Ser Ile Phe Ala Leu Leu Xaa Leu Xaa 
        275                 280                 285             


Val Phe Leu Leu Leu Leu Ala Asp Lys Val Pro Glu Xaa Ser Leu Ser 
    290                 295                 300                 


Val Pro Ile Ile Ile Lys Tyr Leu Met Phe Xaa Met Val Leu Val Xaa 
305                 310                 315                 320 


Phe Ser Val Ile Leu Ser Val Val Val Leu Asn Leu His His Arg Ser 
                325                 330                 335     


Pro His Xaa His Gln Met Pro Leu Trp Val Arg Gln Ile Phe Ile His 
            340                 345                 350         


Lys Leu Pro Leu Tyr Leu Arg Leu Lys Arg Pro Lys Pro Glu Arg Asp 
        355                 360                 365             


Leu Met Pro Glu Pro Pro His Cys Ser Ser Pro Gly Ser Gly Trp Gly 
    370                 375                 380                 


Arg Gly Xaa Asp Glu Tyr Phe Ile Arg Lys Pro Pro Ser Asp Phe Leu 
385                 390                 395                 400 


Phe Pro Lys Pro Asn Arg Phe Gln Pro Glu Leu Ser Ala Pro Asp Leu 
                405                 410                 415     


Arg Arg Phe Ile Asp Gly Pro Asn Arg Ala Val Ala Leu Leu Pro Glu 
            420                 425                 430         


Leu Arg Glu Val Val Ser Ser Ile Ser Tyr Ile Ala Arg Gln Leu Gln 
        435                 440                 445             


Glu Gln Glu Asp His Asp Ala Leu Lys Glu Asp Trp Gln Phe Val Ala 
    450                 455                 460                 


Met Val Val Asp Arg Leu Phe Leu Trp Xaa Phe Ile Ile Phe Xaa Ser 
465                 470                 475                 480 


Val Gly Xaa Leu Val Ile Phe Leu Asp Ala Xaa Tyr His Leu Pro Pro 
                485                 490                 495     


Pro Asp Pro Phe Pro 
            500     


<210> 6202
<211> 37
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 6202
Met Val Val Asp Arg Leu Phe Leu Trp Xaa Phe Ile Ile Phe Xaa Ser 
1               5                   10                  15      


Val Gly Xaa Leu Val Ile Phe Leu Asp Ala Xaa Tyr His Leu Pro Pro 
            20                  25                  30          


Pro Asp Pro Phe Pro 
        35          


<210> 6203
<211> 316
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<400> 6203
Xaa Pro Ala Arg Glu Val Gly Asp Arg Val Arg Val Ser Val Gly Leu 
1               5                   10                  15      


Ile Leu Ala Gln Leu Ile Ser Leu Asn Glu Lys Asp Glu Glu Met Ser 
            20                  25                  30          


Xaa Lys Val Tyr Leu Asp Leu Glu Trp Xaa Asp Tyr Arg Leu Ser Trp 
        35                  40                  45              


Asp Pro Ala Glu His Asp Gly Ile Asp Ser Leu Arg Ile Xaa Ala Glu 
    50                  55                  60                  


Ser Val Trp Leu Pro Asp Val Val Leu Leu Asn Asn Asn Asp Gly Asn 
65                  70                  75                  80  


Phe Asp Val Ala Leu Asp Ile Ser Val Val Val Ser Ser Asp Gly Ser 
                85                  90                  95      


Val Arg Trp Gln Pro Pro Gly Ile Tyr Arg Ser Ser Cys Ser Ile Gln 
            100                 105                 110         


Val Xaa Tyr Phe Pro Phe Asp Trp Gln Asn Cys Xaa Met Val Phe Ser 
        115                 120                 125             


Ser Tyr Ser Tyr Asp Ser Ser Glu Val Ser Leu Gln Xaa Gly Leu Gly 
    130                 135                 140                 


Pro Asp Gly Gln Gly His Gln Glu Ile His Ile His Glu Gly Xaa Phe 
145                 150                 155                 160 


Ile Gly Glu Lys Met Gly Leu Ser Ile Phe Ala Leu Leu Xaa Leu Xaa 
                165                 170                 175     


Val Phe Leu Leu Leu Leu Ala Asp Lys Val Pro Glu Xaa Ser Leu Ser 
            180                 185                 190         


Val Pro Ile Ile Ile Lys Tyr Leu Met Phe Xaa Met Val Leu Val Xaa 
        195                 200                 205             


Phe Ser Val Ile Leu Ser Val Val Val Leu Asn Leu His His Arg Ser 
    210                 215                 220                 


Pro His Xaa His Gln Met Pro Leu Trp Val Arg Gln Ile Phe Ile His 
225                 230                 235                 240 


Lys Leu Pro Leu Tyr Leu Arg Leu Lys Arg Pro Lys Pro Glu Arg Asp 
                245                 250                 255     


Leu Met Pro Glu Pro Pro His Cys Ser Ser Pro Gly Ser Gly Trp Gly 
            260                 265                 270         


Arg Gly Xaa Asp Glu Tyr Phe Ile Arg Lys Pro Pro Ser Asp Phe Leu 
        275                 280                 285             


Phe Pro Lys Pro Asn Arg Phe Gln Pro Glu Leu Ser Ala Pro Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ile Asp Gly Pro Asn Arg Ala Val Ala 
305                 310                 315     


<210> 6204
<211> 502
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(490)
<223> Selenocysteine

<400> 6204
Met Ala Arg Arg Cys Gly Pro Val Ala Leu Leu Leu Gly Phe Gly Leu 
1               5                   10                  15      


Leu Arg Leu Cys Ser Gly Val Trp Gly Xaa Asp Xaa Glu Glu Arg Leu 
            20                  25                  30          


Val Glu His Leu Leu Asp Pro Ser Arg Tyr Asn Lys Leu Ile Arg Pro 
        35                  40                  45              


Ala Xaa Asn Gly Ser Glu Leu Val Xaa Val Gln Leu Met Val Ser Leu 
    50                  55                  60                  


Ala Gln Leu Ile Ser Val His Glu Arg Glu Gln Ile Met Xaa Xaa Asn 
65                  70                  75                  80  


Val Trp Leu Xaa Gln Glu Trp Glu Asp Tyr Arg Leu Xaa Trp Lys Pro 
                85                  90                  95      


Glu Glu Phe Asp Asn Met Lys Lys Val Arg Leu Pro Ser Lys His Ile 
            100                 105                 110         


Trp Leu Pro Asp Val Val Leu Tyr Asn Asn Ala Asp Gly Met Tyr Glu 
        115                 120                 125             


Val Ser Phe Tyr Ser Asn Ala Val Val Ser Tyr Asp Gly Ser Ile Phe 
    130                 135                 140                 


Trp Leu Pro Pro Ala Ile Tyr Lys Ser Ala Cys Lys Ile Glu Val Lys 
145                 150                 155                 160 


His Phe Pro Phe Asp Gln Gln Asn Cys Xaa Met Lys Phe Arg Ser Trp 
                165                 170                 175     


Xaa Tyr Asp Arg Xaa Glu Ile Asp Leu Val Leu Lys Ser Glu Val Ala 
            180                 185                 190         


Ser Leu Asp Asp Phe Xaa Pro Ser Gly Glu Trp Asp Ile Val Ala Leu 
        195                 200                 205             


Pro Gly Arg Arg Asn Glu Asn Pro Asp Asp Ser Xaa Tyr Val Asp Ile 
    210                 215                 220                 


Xaa Tyr Asp Phe Ile Ile Arg Arg Lys Pro Leu Phe Tyr Xaa Ile Asn 
225                 230                 235                 240 


Leu Ile Ile Pro Cys Val Leu Ile Xaa Ser Leu Ala Ile Leu Val Phe 
                245                 250                 255     


Tyr Leu Pro Ser Asp Cys Gly Glu Lys Met Xaa Leu Cys Ile Ser Val 
            260                 265                 270         


Leu Leu Ala Leu Xaa Val Phe Leu Leu Leu Ile Ser Lys Ile Val Pro 
        275                 280                 285             


Pro Xaa Ser Leu Asp Val Pro Leu Val Gly Lys Tyr Leu Met Phe Xaa 
    290                 295                 300                 


Met Val Leu Val Xaa Phe Ser Ile Val Xaa Ser Val Cys Val Leu Asn 
305                 310                 315                 320 


Val His His Arg Ser Pro Xaa Xaa His Xaa Met Ala Pro Trp Val Lys 
                325                 330                 335     


Val Val Phe Leu Glu Lys Leu Pro Ala Leu Leu Phe Met Gln Gln Pro 
            340                 345                 350         


Arg His His Cys Ala Arg Gln Arg Leu Arg Leu Arg Arg Arg Gln Arg 
        355                 360                 365             


Glu Arg Glu Gly Ala Gly Ala Leu Phe Phe Arg Glu Ala Pro Gly Ala 
    370                 375                 380                 


Asp Ser Cys Xaa Cys Phe Val Asn Arg Ala Ser Val Gln Gly Leu Ala 
385                 390                 395                 400 


Gly Ala Phe Gly Ala Glu Pro Ala Pro Val Ala Gly Pro Gly Arg Ser 
                405                 410                 415     


Gly Glu Pro Cys Gly Cys Gly Leu Arg Glu Ala Val Asp Gly Val Arg 
            420                 425                 430         


Phe Ile Ala Asp His Met Arg Ser Glu Asp Asp Asp Gln Ser Val Ser 
        435                 440                 445             


Glu Asp Trp Lys Tyr Val Ala Met Val Ile Asp Arg Leu Phe Leu Trp 
    450                 455                 460                 


Ile Phe Val Phe Val Cys Val Phe Gly Xaa Ile Gly Met Phe Leu Gln 
465                 470                 475                 480 


Pro Leu Phe Gln Asn Tyr Xaa Xaa Xaa Xaa Phe Leu His Ser Asp His 
                485                 490                 495     


Ser Ala Pro Ser Ser Lys 
            500         


<210> 6205
<211> 518
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(490)
<223> Selenocysteine

<400> 6205
Met Ala Arg Arg Cys Gly Pro Val Ala Leu Leu Leu Gly Phe Gly Leu 
1               5                   10                  15      


Leu Arg Leu Cys Ser Gly Val Trp Gly Xaa Asp Xaa Glu Glu Arg Leu 
            20                  25                  30          


Val Glu His Leu Leu Asp Pro Ser Arg Tyr Asn Lys Leu Ile Arg Pro 
        35                  40                  45              


Ala Xaa Asn Gly Ser Glu Leu Val Xaa Val Gln Leu Met Val Ser Leu 
    50                  55                  60                  


Ala Gln Leu Ile Ser Val His Glu Arg Glu Gln Ile Met Xaa Xaa Asn 
65                  70                  75                  80  


Val Trp Leu Xaa Gln Glu Trp Glu Asp Tyr Arg Leu Xaa Trp Lys Pro 
                85                  90                  95      


Glu Glu Phe Asp Asn Met Lys Lys Val Arg Leu Pro Ser Lys His Ile 
            100                 105                 110         


Trp Leu Pro Asp Val Val Leu Tyr Asn Asn Ala Asp Gly Met Tyr Glu 
        115                 120                 125             


Val Ser Phe Tyr Ser Asn Ala Val Val Ser Tyr Asp Gly Ser Ile Phe 
    130                 135                 140                 


Trp Leu Pro Pro Ala Ile Tyr Lys Ser Ala Cys Lys Ile Glu Val Lys 
145                 150                 155                 160 


His Phe Pro Phe Asp Gln Gln Asn Cys Xaa Met Lys Phe Arg Ser Trp 
                165                 170                 175     


Xaa Tyr Asp Arg Xaa Glu Ile Asp Leu Val Leu Lys Ser Glu Val Ala 
            180                 185                 190         


Ser Leu Asp Asp Phe Xaa Pro Ser Gly Glu Trp Asp Ile Val Ala Leu 
        195                 200                 205             


Pro Gly Arg Arg Asn Glu Asn Pro Asp Asp Ser Xaa Tyr Val Asp Ile 
    210                 215                 220                 


Xaa Tyr Asp Phe Ile Ile Arg Arg Lys Pro Leu Phe Tyr Xaa Ile Asn 
225                 230                 235                 240 


Leu Ile Ile Pro Cys Val Leu Ile Xaa Ser Leu Ala Ile Leu Val Phe 
                245                 250                 255     


Tyr Leu Pro Ser Asp Cys Gly Glu Lys Met Xaa Leu Cys Ile Ser Val 
            260                 265                 270         


Leu Leu Ala Leu Xaa Val Phe Leu Leu Leu Ile Ser Lys Ile Val Pro 
        275                 280                 285             


Pro Xaa Ser Leu Asp Val Pro Leu Val Gly Lys Tyr Leu Met Phe Xaa 
    290                 295                 300                 


Met Val Leu Val Xaa Phe Ser Ile Val Xaa Ser Val Cys Val Leu Asn 
305                 310                 315                 320 


Val His His Arg Ser Pro Xaa Xaa His Xaa Met Ala Pro Trp Val Lys 
                325                 330                 335     


Val Val Phe Leu Glu Lys Leu Pro Ala Leu Leu Phe Met Gln Gln Pro 
            340                 345                 350         


Arg His His Cys Ala Arg Gln Arg Leu Arg Leu Arg Arg Arg Gln Arg 
        355                 360                 365             


Glu Arg Glu Gly Ala Gly Ala Leu Phe Phe Arg Glu Ala Pro Gly Ala 
    370                 375                 380                 


Asp Ser Cys Xaa Cys Phe Val Asn Arg Ala Ser Val Gln Gly Leu Ala 
385                 390                 395                 400 


Gly Ala Phe Gly Ala Glu Pro Ala Pro Val Ala Gly Pro Gly Arg Ser 
                405                 410                 415     


Gly Glu Pro Cys Gly Cys Gly Leu Arg Glu Ala Val Asp Gly Val Arg 
            420                 425                 430         


Phe Ile Ala Asp His Met Arg Ser Glu Asp Asp Asp Gln Ser Val Ser 
        435                 440                 445             


Glu Asp Trp Lys Tyr Val Ala Met Val Ile Asp Arg Leu Phe Leu Trp 
    450                 455                 460                 


Ile Phe Val Phe Val Cys Val Phe Gly Xaa Ile Gly Met Phe Leu Gln 
465                 470                 475                 480 


Pro Leu Phe Gln Asn Tyr Xaa Xaa Xaa Xaa Phe Leu His Ser Asp His 
                485                 490                 495     


Ser Ala Pro Ser Ser Lys Leu Lys Val Trp Gly Ala Arg Leu Ser Ile 
            500                 505                 510         


Arg Gly Ala Ser Glu Phe 
        515             


<210> 6206
<211> 504
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(492)
<223> Selenocysteine

<400> 6206
Met Ala Arg Arg Cys Gly Pro Val Ala Leu Leu Leu Gly Phe Gly Leu 
1               5                   10                  15      


Leu Arg Leu Cys Ser Gly Val Trp Gly Xaa Asp Xaa Glu Glu Arg Leu 
            20                  25                  30          


Val Glu His Leu Leu Asp Pro Ser Arg Tyr Asn Lys Leu Ile Arg Pro 
        35                  40                  45              


Ala Xaa Asn Gly Ser Glu Leu Val Xaa Val Gln Leu Met Val Ser Leu 
    50                  55                  60                  


Ala Gln Leu Ile Ser Val His Glu Arg Glu Gln Ile Met Xaa Xaa Asn 
65                  70                  75                  80  


Val Trp Leu Xaa Gln Val Ser Glu Trp Glu Asp Tyr Arg Leu Xaa Trp 
                85                  90                  95      


Lys Pro Glu Glu Phe Asp Asn Met Lys Lys Val Arg Leu Pro Ser Lys 
            100                 105                 110         


His Ile Trp Leu Pro Asp Val Val Leu Tyr Asn Asn Ala Asp Gly Met 
        115                 120                 125             


Tyr Glu Val Ser Phe Tyr Ser Asn Ala Val Val Ser Tyr Asp Gly Ser 
    130                 135                 140                 


Ile Phe Trp Leu Pro Pro Ala Ile Tyr Lys Ser Ala Cys Lys Ile Glu 
145                 150                 155                 160 


Val Lys His Phe Pro Phe Asp Gln Gln Asn Cys Xaa Met Lys Phe Arg 
                165                 170                 175     


Ser Trp Xaa Tyr Asp Arg Xaa Glu Ile Asp Leu Val Leu Lys Ser Glu 
            180                 185                 190         


Val Ala Ser Leu Asp Asp Phe Xaa Pro Ser Gly Glu Trp Asp Ile Val 
        195                 200                 205             


Ala Leu Pro Gly Arg Arg Asn Glu Asn Pro Asp Asp Ser Xaa Tyr Val 
    210                 215                 220                 


Asp Ile Xaa Tyr Asp Phe Ile Ile Arg Arg Lys Pro Leu Phe Tyr Xaa 
225                 230                 235                 240 


Ile Asn Leu Ile Ile Pro Cys Val Leu Ile Xaa Ser Leu Ala Ile Leu 
                245                 250                 255     


Val Phe Tyr Leu Pro Ser Asp Cys Gly Glu Lys Met Xaa Leu Cys Ile 
            260                 265                 270         


Ser Val Leu Leu Ala Leu Xaa Val Phe Leu Leu Leu Ile Ser Lys Ile 
        275                 280                 285             


Val Pro Pro Xaa Ser Leu Asp Val Pro Leu Val Gly Lys Tyr Leu Met 
    290                 295                 300                 


Phe Xaa Met Val Leu Val Xaa Phe Ser Ile Val Xaa Ser Val Cys Val 
305                 310                 315                 320 


Leu Asn Val His His Arg Ser Pro Xaa Xaa His Xaa Met Ala Pro Trp 
                325                 330                 335     


Val Lys Val Val Phe Leu Glu Lys Leu Pro Ala Leu Leu Phe Met Gln 
            340                 345                 350         


Gln Pro Arg His His Cys Ala Arg Gln Arg Leu Arg Leu Arg Arg Arg 
        355                 360                 365             


Gln Arg Glu Arg Glu Gly Ala Gly Ala Leu Phe Phe Arg Glu Ala Pro 
    370                 375                 380                 


Gly Ala Asp Ser Cys Xaa Cys Phe Val Asn Arg Ala Ser Val Gln Gly 
385                 390                 395                 400 


Leu Ala Gly Ala Phe Gly Ala Glu Pro Ala Pro Val Ala Gly Pro Gly 
                405                 410                 415     


Arg Ser Gly Glu Pro Cys Gly Cys Gly Leu Arg Glu Ala Val Asp Gly 
            420                 425                 430         


Val Arg Phe Ile Ala Asp His Met Arg Ser Glu Asp Asp Asp Gln Ser 
        435                 440                 445             


Val Ser Glu Asp Trp Lys Tyr Val Ala Met Val Ile Asp Arg Leu Phe 
    450                 455                 460                 


Leu Trp Ile Phe Val Phe Val Cys Val Phe Gly Xaa Ile Gly Met Phe 
465                 470                 475                 480 


Leu Gln Pro Leu Phe Gln Asn Tyr Xaa Xaa Xaa Xaa Phe Leu His Ser 
                485                 490                 495     


Asp His Ser Ala Pro Ser Ser Lys 
            500                 


<210> 6207
<211> 34
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<400> 6207
Xaa Leu Ile Arg Pro Ala Xaa Asn Gly Ser Glu Leu Val Xaa Val Gln 
1               5                   10                  15      


Leu Met Val Ser Leu Ala Gln Leu Ile Ser Val Pro Leu Phe Leu Pro 
            20                  25                  30          


Ala Ala 
        


<210> 6208
<211> 458
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<400> 6208
Met Leu Pro Asp Phe Met Leu Val Leu Ile Val Leu Gly Ile Pro Ser 
1               5                   10                  15      


Ser Ala Xaa Xaa Gly Phe Asn Ser Ile Ala Glu Asn Glu Asp Ala Leu 
            20                  25                  30          


Leu Arg His Leu Phe Gln Gly Tyr Gln Lys Trp Val Arg Pro Val Leu 
        35                  40                  45              


His Ser Asn Asp Xaa Ile Lys Val Tyr Phe Gly Leu Lys Ile Ser Gln 
    50                  55                  60                  


Leu Val Asp Val Asp Glu Lys Asn Gln Leu Met Xaa Xaa Asn Val Trp 
65                  70                  75                  80  


Leu Lys Gln Glu Trp Xaa Asp His Lys Leu Arg Trp Asn Pro Asp Asp 
                85                  90                  95      


Tyr Gly Gly Ile His Ser Ile Lys Val Pro Ser Glu Ser Leu Trp Leu 
            100                 105                 110         


Pro Asp Ile Val Leu Phe Glu Asn Ala Asp Gly Arg Phe Glu Gly Ser 
        115                 120                 125             


Leu Met Xaa Lys Val Ile Val Lys Ser Asn Gly Xaa Val Val Trp Xaa 
    130                 135                 140                 


Pro Pro Ala Ser Tyr Lys Ser Ser Cys Xaa Met Asp Val Xaa Phe Phe 
145                 150                 155                 160 


Pro Phe Asp Arg Gln Asn Cys Ser Met Lys Phe Gly Ser Trp Xaa Tyr 
                165                 170                 175     


Asp Gly Xaa Met Val Asp Leu Ile Leu Ile Asn Glu Asn Val Asp Arg 
            180                 185                 190         


Lys Asp Phe Phe Asp Asn Gly Glu Trp Glu Ile Leu Asn Ala Lys Gly 
        195                 200                 205             


Met Lys Gly Asn Arg Arg Asp Gly Val Tyr Ser Tyr Pro Phe Ile Xaa 
    210                 215                 220                 


Tyr Ser Phe Val Leu Arg Arg Leu Pro Leu Phe Tyr Xaa Leu Phe Leu 
225                 230                 235                 240 


Ile Ile Pro Cys Leu Gly Leu Ser Phe Leu Xaa Val Leu Val Phe Tyr 
                245                 250                 255     


Leu Pro Ser Asp Glu Gly Glu Lys Leu Ser Leu Ser Xaa Ser Val Leu 
            260                 265                 270         


Val Ser Leu Xaa Val Phe Leu Leu Val Ile Glu Glu Ile Ile Pro Ser 
        275                 280                 285             


Ser Ser Lys Val Ile Pro Leu Ile Gly Glu Tyr Leu Leu Phe Ile Met 
    290                 295                 300                 


Ile Phe Val Xaa Leu Ser Ile Ile Val Xaa Val Phe Val Ile Asn Val 
305                 310                 315                 320 


His His Arg Ser Ser Ser Xaa Tyr His Pro Met Ala Pro Trp Val Lys 
                325                 330                 335     


Arg Leu Phe Leu Gln Lys Leu Pro Lys Leu Leu Cys Met Lys Asp His 
            340                 345                 350         


Val Asp Arg Tyr Ser Ser Pro Glu Lys Glu Glu Ser Gln Pro Val Val 
        355                 360                 365             


Lys Gly Lys Val Leu Glu Lys Lys Lys Gln Lys Gln Leu Ser Asp Gly 
    370                 375                 380                 


Glu Lys Val Leu Val Ala Phe Leu Glu Lys Ala Ala Asp Ser Ile Arg 
385                 390                 395                 400 


Tyr Ile Ser Arg His Val Lys Lys Glu His Phe Ile Ser Gln Val Val 
                405                 410                 415     


Gln Asp Trp Lys Phe Val Ala Gln Val Leu Asp Arg Ile Phe Leu Trp 
            420                 425                 430         


Leu Phe Leu Ile Val Ser Val Xaa Gly Ser Val Leu Ile Phe Xaa Pro 
        435                 440                 445             


Ala Leu Lys Met Trp Leu His Ser Tyr His 
    450                 455             


<210> 6209
<211> 9
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<400> 6209
Met Xaa Xaa Asn Val Trp Leu Lys Gln 
1               5                   


<210> 6210
<211> 66
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<400> 6210
Met Gly Gly Ser Leu Leu Ala Pro Ala Pro Asp His Ile Val Leu Trp 
1               5                   10                  15      


Asn Cys Arg Val Ala Asn Ala Glu Glu Lys Leu Met Asp Asp Leu Leu 
            20                  25                  30          


Asn Lys Xaa Arg Tyr Asn Asn Leu Ile Arg Pro Ala Xaa Ser Ser Ser 
        35                  40                  45              


Gln Leu Ile Ser Ile Lys Leu Gln Leu Ser Leu Ala Gln Leu Ile Ser 
    50                  55                  60                  


Val Gly 
65      


<210> 6211
<211> 231
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<400> 6211
Met Arg Arg Ala Pro Ser Leu Val Leu Phe Phe Leu Val Ala Leu Cys 
1               5                   10                  15      


Gly Arg Gly Asn Cys Arg Val Ala Asn Ala Glu Glu Lys Leu Met Asp 
            20                  25                  30          


Asp Leu Leu Asn Lys Xaa Arg Tyr Asn Asn Leu Ile Arg Pro Ala Xaa 
        35                  40                  45              


Ser Ser Ser Gln Leu Ile Ser Ile Lys Leu Gln Leu Ser Leu Ala Gln 
    50                  55                  60                  


Leu Ile Ser Val Asn Glu Arg Glu Gln Ile Met Xaa Xaa Asn Val Trp 
65                  70                  75                  80  


Leu Lys Gln Glu Trp Xaa Asp Tyr Arg Leu Xaa Trp Asn Ser Ser Arg 
                85                  90                  95      


Tyr Glu Gly Val Asn Ile Leu Arg Ile Pro Ala Lys Arg Ile Trp Leu 
            100                 105                 110         


Pro Asp Ile Val Leu Tyr Asn Lys Ser Leu Arg Xaa Gly Ser Xaa Trp 
        115                 120                 125             


Leu Trp Trp Trp Xaa Gly Cys Ser Cys Gly Cys Ser Cys Leu Cys Ala 
    130                 135                 140                 


Ser Trp Ala Leu Trp Gly Ser Ser Tyr Arg Pro Ser Ser Arg Pro Met 
145                 150                 155                 160 


Gln Leu Leu Arg Gly Pro Xaa Leu Pro Ser Val Xaa Glu Gly Pro Leu 
                165                 170                 175     


Gly Cys Gly Val Arg Gly Cys Glu Trp Pro Gly Gly His Phe Ala Ala 
            180                 185                 190         


Ser Phe Trp Val Val Ala Asp Glu Ala Leu Ser Lys Tyr Val Ser Ile 
        195                 200                 205             


Gly His Gln Pro His Gln Xaa Ser His Ser Arg Gly Xaa Gly Lys Asp 
    210                 215                 220                 


Gly Gly Leu Gly Cys Pro Leu 
225                 230     


<210> 6212
<211> 498
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<400> 6212
Met Arg Arg Ala Pro Ser Leu Val Leu Phe Phe Leu Val Ala Leu Cys 
1               5                   10                  15      


Gly Arg Gly Asn Cys Arg Val Ala Asn Ala Glu Glu Lys Leu Met Asp 
            20                  25                  30          


Asp Leu Leu Asn Lys Xaa Arg Tyr Asn Asn Leu Ile Arg Pro Ala Xaa 
        35                  40                  45              


Ser Ser Ser Gln Leu Ile Ser Ile Lys Leu Gln Leu Ser Leu Ala Gln 
    50                  55                  60                  


Leu Ile Ser Val Asn Glu Arg Glu Gln Ile Met Xaa Xaa Asn Val Trp 
65                  70                  75                  80  


Leu Lys Gln Glu Trp Xaa Asp Tyr Arg Leu Xaa Trp Asn Ser Ser Arg 
                85                  90                  95      


Tyr Glu Gly Val Asn Ile Leu Arg Ile Pro Ala Lys Arg Ile Trp Leu 
            100                 105                 110         


Pro Asp Ile Val Leu Tyr Asn Asn Ala Asp Gly Xaa Tyr Glu Val Ser 
        115                 120                 125             


Val Tyr Xaa Asn Leu Ile Val Arg Ser Asn Gly Ser Val Leu Trp Leu 
    130                 135                 140                 


Pro Pro Ala Ile Tyr Lys Ser Ala Cys Lys Ile Glu Val Lys Tyr Phe 
145                 150                 155                 160 


Pro Phe Asp Gln Gln Asn Cys Xaa Leu Lys Phe Arg Ser Trp Xaa Tyr 
                165                 170                 175     


Asp His Xaa Glu Ile Asp Met Val Leu Met Xaa Pro Xaa Ala Ser Met 
            180                 185                 190         


Asp Asp Phe Xaa Pro Ser Gly Glu Trp Asp Ile Val Ala Leu Pro Gly 
        195                 200                 205             


Arg Arg Xaa Val Asn Pro Gln Asp Pro Ser Tyr Val Asp Val Xaa Tyr 
    210                 215                 220                 


Asp Phe Ile Ile Lys Arg Lys Pro Leu Phe Tyr Xaa Ile Asn Leu Ile 
225                 230                 235                 240 


Ile Pro Cys Val Leu Xaa Xaa Leu Leu Ala Ile Leu Val Phe Tyr Leu 
                245                 250                 255     


Pro Ser Asp Cys Gly Glu Lys Met Xaa Leu Cys Ile Ser Val Leu Leu 
            260                 265                 270         


Ala Leu Xaa Phe Phe Leu Leu Leu Ile Ser Lys Ile Val Pro Pro Xaa 
        275                 280                 285             


Ser Leu Asp Val Pro Leu Ile Gly Lys Tyr Leu Met Phe Xaa Met Val 
    290                 295                 300                 


Leu Val Xaa Phe Ser Ile Val Xaa Ser Val Cys Val Leu Asn Val His 
305                 310                 315                 320 


His Arg Ser Pro Ser Xaa His Xaa Met Ala Pro Trp Val Lys Arg Cys 
                325                 330                 335     


Phe Leu His Lys Leu Pro Xaa Phe Leu Phe Met Lys Arg Pro Gly Pro 
            340                 345                 350         


Asp Ser Ser Pro Ala Arg Ala Phe Pro Pro Ser Lys Ser Cys Val Xaa 
        355                 360                 365             


Lys Pro Glu Ala Xaa Ala Xaa Ser Xaa Ser Pro Ser Asn Phe Tyr Gly 
    370                 375                 380                 


Asn Ser Met Tyr Phe Val Asn Pro Ala Ser Ala Ala Ser Lys Ser Pro 
385                 390                 395                 400 


Ala Gly Ser Xaa Pro Val Ala Ile Pro Arg Asp Phe Trp Leu Arg Ser 
                405                 410                 415     


Ser Gly Arg Phe Arg Gln Asp Val Gln Glu Ala Leu Glu Gly Val Ser 
            420                 425                 430         


Phe Ile Ala Gln His Met Lys Asn Asp Asp Glu Asp Gln Ser Val Val 
        435                 440                 445             


Glu Asp Trp Lys Tyr Val Ala Met Val Val Asp Arg Leu Phe Leu Trp 
    450                 455                 460                 


Val Phe Met Phe Val Cys Val Leu Gly Xaa Val Gly Leu Phe Leu Pro 
465                 470                 475                 480 


Pro Leu Phe Gln Xaa His Ala Ala Ser Glu Gly Pro Tyr Ala Ala Gln 
                485                 490                 495     


Arg Asp 
        


<210> 6213
<211> 172
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 6213
Met Glu Gly Pro Val Leu Xaa Leu Gly Leu Leu Ala Ala Leu Ala Val 
1               5                   10                  15      


Cys Gly Ser Trp Gly Leu Asn Glu Glu Glu Arg Leu Ile Arg His Leu 
            20                  25                  30          


Phe Gln Glu Lys Gly Tyr Asn Lys Glu Leu Arg Pro Val Ala His Lys 
        35                  40                  45              


Glu Glu Ser Val Asp Val Ala Leu Ala Leu Xaa Leu Ser Asn Leu Ile 
    50                  55                  60                  


Ser Leu Gly Trp Xaa Asp Asn Arg Leu Lys Trp Asn Ala Glu Glu Phe 
65                  70                  75                  80  


Gly Asn Ile Ser Val Leu Arg Leu Pro Pro Asp Met Val Trp Leu Pro 
                85                  90                  95      


Glu Ile Val Leu Glu Asn Asn Asn Asp Gly Ser Phe Gln Ile Ser Tyr 
            100                 105                 110         


Ser Cys Asn Val Leu Val Tyr His Tyr Gly Phe Val Tyr Trp Leu Pro 
        115                 120                 125             


Pro Ala Ile Phe Arg Ser Ser Cys Pro Ile Ser Val Xaa Tyr Phe Pro 
    130                 135                 140                 


Phe Asp Trp Gln Asn Cys Ser Leu Lys Phe Ser Ser Leu Lys Tyr Xaa 
145                 150                 155                 160 


Ala Lys Glu Ile Xaa Leu Ser Leu Lys Gln Asp Ala 
                165                 170         


<210> 6214
<211> 502
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<400> 6214
Met Glu Gly Pro Val Leu Xaa Leu Gly Leu Leu Ala Ala Leu Ala Val 
1               5                   10                  15      


Cys Gly Ser Trp Gly Leu Asn Glu Glu Glu Arg Leu Ile Arg His Leu 
            20                  25                  30          


Phe Gln Glu Lys Gly Tyr Asn Lys Glu Leu Arg Pro Val Ala His Lys 
        35                  40                  45              


Glu Glu Ser Val Asp Val Ala Leu Ala Leu Xaa Leu Ser Asn Leu Ile 
    50                  55                  60                  


Ser Leu Gly Trp Xaa Asp Asn Arg Leu Lys Trp Asn Ala Glu Glu Phe 
65                  70                  75                  80  


Gly Asn Ile Ser Val Leu Arg Leu Pro Pro Asp Met Val Trp Leu Pro 
                85                  90                  95      


Glu Ile Val Leu Glu Asn Asn Asn Asp Gly Ser Phe Gln Ile Ser Tyr 
            100                 105                 110         


Ser Cys Asn Val Leu Val Tyr His Tyr Gly Phe Val Tyr Trp Leu Pro 
        115                 120                 125             


Pro Ala Ile Phe Arg Ser Ser Cys Pro Ile Ser Val Xaa Tyr Phe Pro 
    130                 135                 140                 


Phe Asp Trp Gln Asn Cys Ser Leu Lys Phe Ser Ser Leu Lys Tyr Xaa 
145                 150                 155                 160 


Ala Lys Glu Ile Xaa Leu Ser Leu Lys Gln Asp Ala Lys Glu Asn Arg 
                165                 170                 175     


Xaa Tyr Pro Val Glu Trp Ile Ile Ile Asp Pro Glu Gly Phe Xaa Glu 
            180                 185                 190         


Asn Gly Glu Trp Glu Ile Val His Arg Pro Ala Arg Val Asn Val Asp 
        195                 200                 205             


Pro Arg Ala Pro Leu Asp Ser Pro Ser Arg Gln Asp Ile Xaa Phe Tyr 
    210                 215                 220                 


Leu Ile Ile Arg Arg Lys Pro Leu Phe Tyr Ile Ile Asn Ile Leu Val 
225                 230                 235                 240 


Pro Cys Val Leu Ile Ser Phe Met Val Asn Leu Val Phe Tyr Leu Pro 
                245                 250                 255     


Ala Asp Ser Gly Glu Lys Xaa Ser Val Ala Ile Ser Val Leu Leu Ala 
            260                 265                 270         


Gln Ser Val Phe Leu Leu Leu Ile Ser Lys Arg Leu Pro Ala Xaa Ser 
        275                 280                 285             


Met Ala Ile Pro Leu Ile Gly Lys Phe Leu Leu Phe Gly Met Val Leu 
    290                 295                 300                 


Val Xaa Met Val Val Val Ile Cys Val Ile Val Leu Asn Ile His Phe 
305                 310                 315                 320 


Arg Xaa Pro Ser Xaa His Val Leu Ser Glu Gly Val Lys Lys Leu Phe 
                325                 330                 335     


Leu Glu Xaa Leu Pro Glu Leu Leu His Met Ser Arg Pro Ala Glu Asp 
            340                 345                 350         


Gly Pro Ser Pro Gly Ala Leu Val Arg Arg Ser Ser Ser Leu Gly Tyr 
        355                 360                 365             


Ile Ser Lys Ala Glu Glu Tyr Phe Leu Leu Lys Ser Arg Ser Asp Leu 
    370                 375                 380                 


Met Phe Glu Lys Gln Ser Glu Arg His Gly Leu Ala Arg Arg Leu Xaa 
385                 390                 395                 400 


Xaa Ala Arg Arg Pro Pro Ala Ser Ser Glu Gln Ala Gln Gln Glu Leu 
                405                 410                 415     


Phe Asn Glu Leu Lys Pro Ala Val Asp Gly Ala Asn Phe Ile Val Asn 
            420                 425                 430         


His Met Arg Asp Gln Asn Asn Tyr Asn Glu Glu Lys Asp Ser Trp Asn 
        435                 440                 445             


Arg Val Ala Arg Xaa Val Asp Arg Leu Cys Leu Phe Val Val Xaa Pro 
    450                 455                 460                 


Val Met Val Val Gly Xaa Ala Trp Ile Phe Leu Gln Gly Val Tyr Asn 
465                 470                 475                 480 


Gln Pro Pro Pro Gln Pro Phe Pro Gly Asp Pro Tyr Ser Tyr Asn Val 
                485                 490                 495     


Gln Asp Lys Arg Phe Ile 
            500         


<210> 6215
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<400> 6215
Met Glu Gly Pro Val Leu Xaa Leu Gly Leu Leu Ala Ala Leu Ala Val 
1               5                   10                  15      


Cys Gly Ser Trp Gly Leu Asn Glu Glu Glu Arg Leu Ile Arg His Leu 
            20                  25                  30          


Phe Gln Glu Lys Gly Tyr Asn Lys Glu Leu Arg Pro Val Ala His Lys 
        35                  40                  45              


Glu Glu Ser Val Asp Val Ala Leu Ala Leu Xaa Leu Ser Asn Leu Ile 
    50                  55                  60                  


Ser Leu Lys Glu Val Glu Glu Xaa Leu Xaa Xaa Asn Val Trp Ile Glu 
65                  70                  75                  80  


His Gly Trp Xaa Asp Asn Arg Leu Lys Trp Asn Ala Glu Glu Phe Gly 
                85                  90                  95      


Asn Ile Ser Val Leu Arg Leu Pro Pro Asp Met Gln 
            100                 105             


<210> 6216
<211> 235
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<400> 6216
Met Glu Gly Pro Val Leu Xaa Leu Gly Leu Leu Ala Ala Leu Ala Val 
1               5                   10                  15      


Cys Gly Ser Trp Gly Leu Asn Glu Glu Glu Arg Leu Ile Arg His Leu 
            20                  25                  30          


Phe Gln Glu Lys Gly Tyr Asn Lys Glu Leu Arg Pro Val Ala His Lys 
        35                  40                  45              


Glu Glu Ser Val Asp Val Ala Leu Ala Leu Xaa Leu Ser Asn Leu Ile 
    50                  55                  60                  


Ser Leu Lys Glu Val Glu Glu Xaa Leu Xaa Xaa Asn Val Trp Ile Glu 
65                  70                  75                  80  


His Gly Trp Xaa Asp Asn Arg Leu Lys Trp Asn Ala Glu Glu Phe Gly 
                85                  90                  95      


Asn Ile Ser Val Leu Arg Leu Pro Pro Asp Met Val Trp Leu Pro Glu 
            100                 105                 110         


Ile Val Leu Glu Asn Asn Asn Asp Gly Ser Phe Gln Ile Ser Tyr Ser 
        115                 120                 125             


Cys Asn Val Leu Val Tyr His Tyr Gly Phe Val Tyr Trp Leu Pro Pro 
    130                 135                 140                 


Ala Ile Phe Arg Ser Ser Cys Pro Ile Ser Val Xaa Tyr Phe Pro Phe 
145                 150                 155                 160 


Asp Trp Gln Asn Cys Ser Leu Lys Phe Arg Glu Arg Gly Val Gly Asp 
                165                 170                 175     


Ser Pro Pro Ala Gly Gln Gly Gln Arg Gly Pro Gln Ser Pro Ser Gly 
            180                 185                 190         


Gln Pro Gln Pro Pro Gly His His Leu Leu Pro His His Pro Pro Gln 
        195                 200                 205             


Ala Pro Leu Leu His His Gln His Pro Gly Ala Leu Arg Ala His Leu 
    210                 215                 220                 


Leu His Gly Gln Pro Gly Leu Leu Pro Xaa Gly 
225                 230                 235 


<210> 6217
<211> 171
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<400> 6217
Met Glu Gly Pro Val Leu Xaa Leu Gly Leu Leu Ala Ala Leu Ala Val 
1               5                   10                  15      


Cys Gly Ser Trp Gly Leu Asn Glu Glu Glu Arg Leu Ile Arg His Leu 
            20                  25                  30          


Phe Gln Glu Lys Gly Tyr Asn Lys Glu Leu Arg Pro Val Ala His Lys 
        35                  40                  45              


Glu Glu Ser Val Asp Val Ala Leu Ala Leu Xaa Leu Ser Asn Leu Ile 
    50                  55                  60                  


Ser Leu Lys Glu Val Glu Glu Xaa Leu Xaa Xaa Asn Val Trp Ile Glu 
65                  70                  75                  80  


His Gly Trp Xaa Asp Asn Arg Leu Lys Trp Asn Ala Glu Glu Phe Gly 
                85                  90                  95      


Asn Ile Ser Val Leu Arg Leu Pro Pro Asp Met Val Trp Leu Pro Glu 
            100                 105                 110         


Ile Val Leu Glu Asn Asn Asn Asp Gly Ser Phe Gln Ile Ser Tyr Ser 
        115                 120                 125             


Cys Asn Val Leu Val Tyr His Tyr Gly Phe Val Tyr Trp Leu Pro Pro 
    130                 135                 140                 


Ala Ile Phe Arg Ser Ser Cys Pro Ile Ser Val Xaa Tyr Phe Pro Phe 
145                 150                 155                 160 


Asp Trp Gln Asn Cys Ser Leu Lys Phe Arg Trp 
                165                 170     


<210> 6218
<211> 517
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<400> 6218
Met Glu Gly Pro Val Leu Xaa Leu Gly Leu Leu Ala Ala Leu Ala Val 
1               5                   10                  15      


Cys Gly Ser Trp Gly Leu Asn Glu Glu Glu Arg Leu Ile Arg His Leu 
            20                  25                  30          


Phe Gln Glu Lys Gly Tyr Asn Lys Glu Leu Arg Pro Val Ala His Lys 
        35                  40                  45              


Glu Glu Ser Val Asp Val Ala Leu Ala Leu Xaa Leu Ser Asn Leu Ile 
    50                  55                  60                  


Ser Leu Lys Glu Val Glu Glu Xaa Leu Xaa Xaa Asn Val Trp Ile Glu 
65                  70                  75                  80  


His Gly Trp Xaa Asp Asn Arg Leu Lys Trp Asn Ala Glu Glu Phe Gly 
                85                  90                  95      


Asn Ile Ser Val Leu Arg Leu Pro Pro Asp Met Val Trp Leu Pro Glu 
            100                 105                 110         


Ile Val Leu Glu Asn Asn Asn Asp Gly Ser Phe Gln Ile Ser Tyr Ser 
        115                 120                 125             


Cys Asn Val Leu Val Tyr His Tyr Gly Phe Val Tyr Trp Leu Pro Pro 
    130                 135                 140                 


Ala Ile Phe Arg Ser Ser Cys Pro Ile Ser Val Xaa Tyr Phe Pro Phe 
145                 150                 155                 160 


Asp Trp Gln Asn Cys Ser Leu Lys Phe Ser Ser Leu Lys Tyr Xaa Ala 
                165                 170                 175     


Lys Glu Ile Xaa Leu Ser Leu Lys Gln Asp Ala Lys Glu Asn Arg Xaa 
            180                 185                 190         


Tyr Pro Val Glu Trp Ile Ile Ile Asp Pro Glu Gly Phe Xaa Glu Asn 
        195                 200                 205             


Gly Glu Trp Glu Ile Val His Arg Pro Ala Arg Val Asn Val Asp Pro 
    210                 215                 220                 


Arg Ala Pro Leu Asp Ser Pro Ser Arg Gln Asp Ile Xaa Phe Tyr Leu 
225                 230                 235                 240 


Ile Ile Arg Arg Lys Pro Leu Phe Tyr Ile Ile Asn Ile Leu Val Pro 
                245                 250                 255     


Cys Val Leu Ile Ser Phe Met Val Asn Leu Val Phe Tyr Leu Pro Ala 
            260                 265                 270         


Asp Ser Gly Glu Lys Xaa Ser Val Ala Ile Ser Val Leu Leu Ala Gln 
        275                 280                 285             


Ser Val Phe Leu Leu Leu Ile Ser Lys Arg Leu Pro Ala Xaa Ser Met 
    290                 295                 300                 


Ala Ile Pro Leu Ile Gly Lys Phe Leu Leu Phe Gly Met Val Leu Val 
305                 310                 315                 320 


Xaa Met Val Val Val Ile Cys Val Ile Val Leu Asn Ile His Phe Arg 
                325                 330                 335     


Xaa Pro Ser Xaa His Val Leu Ser Glu Gly Val Lys Lys Leu Phe Leu 
            340                 345                 350         


Glu Xaa Leu Pro Glu Leu Leu His Met Ser Arg Pro Ala Glu Asp Gly 
        355                 360                 365             


Pro Ser Pro Gly Ala Leu Val Arg Arg Ser Ser Ser Leu Gly Tyr Ile 
    370                 375                 380                 


Ser Lys Ala Glu Glu Tyr Phe Leu Leu Lys Ser Arg Ser Asp Leu Met 
385                 390                 395                 400 


Phe Glu Lys Gln Ser Glu Arg His Gly Leu Ala Arg Arg Leu Xaa Xaa 
                405                 410                 415     


Ala Arg Arg Pro Pro Ala Ser Ser Glu Gln Ala Gln Gln Glu Leu Phe 
            420                 425                 430         


Asn Glu Leu Lys Pro Ala Val Asp Gly Ala Asn Phe Ile Val Asn His 
        435                 440                 445             


Met Arg Asp Gln Asn Asn Tyr Asn Glu Glu Lys Asp Ser Trp Asn Arg 
    450                 455                 460                 


Val Ala Arg Xaa Val Asp Arg Leu Cys Leu Phe Val Val Xaa Pro Val 
465                 470                 475                 480 


Met Val Val Gly Xaa Ala Trp Ile Phe Leu Gln Gly Val Tyr Asn Gln 
                485                 490                 495     


Pro Pro Pro Gln Pro Phe Pro Gly Asp Pro Tyr Ser Tyr Asn Val Gln 
            500                 505                 510         


Asp Lys Arg Phe Ile 
        515         


<210> 6219
<211> 493
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<400> 6219
Met Ala Arg Ala Pro Leu Gly Val Leu Leu Leu Leu Gly Leu Leu Gly 
1               5                   10                  15      


Arg Gly Val Gly Lys Asn Glu Glu Leu Arg Leu Tyr His His Leu Phe 
            20                  25                  30          


Asn Asn Tyr Asp Pro Gly Ser Arg Pro Val Arg Glu Pro Glu Asp Xaa 
        35                  40                  45              


Val Xaa Ile Ser Leu Lys Val Xaa Leu Xaa Asn Leu Ile Ser Leu Asn 
    50                  55                  60                  


Glu Lys Glu Glu Xaa Leu Xaa Xaa Ser Val Trp Ile Gly Ile Asp Trp 
65                  70                  75                  80  


Gln Asp Tyr Arg Leu Asn Tyr Ser Lys Asp Asp Phe Gly Gly Ile Glu 
                85                  90                  95      


Xaa Leu Arg Val Pro Ser Glu Leu Val Trp Leu Pro Glu Ile Val Leu 
            100                 105                 110         


Glu Asn Asn Ile Asp Gly Gln Phe Gly Val Ala Tyr Asp Ala Asn Val 
        115                 120                 125             


Leu Val Tyr Glu Gly Gly Ser Val Xaa Trp Leu Pro Pro Ala Ile Tyr 
    130                 135                 140                 


Arg Ser Val Cys Ala Val Glu Val Xaa Tyr Phe Pro Phe Asp Trp Gln 
145                 150                 155                 160 


Asn Cys Ser Leu Ile Phe Arg Ser Gln Xaa Tyr Asn Ala Glu Glu Val 
                165                 170                 175     


Glu Phe Xaa Phe Ala Val Asp Asn Asp Gly Lys Xaa Ile Asn Lys Ile 
            180                 185                 190         


Asp Ile Asp Xaa Glu Ala Tyr Xaa Glu Asn Gly Glu Trp Ala Ile Asp 
        195                 200                 205             


Phe Cys Pro Gly Val Ile Arg Arg His His Gly Gly Ala Xaa Asp Gly 
    210                 215                 220                 


Pro Gly Glu Xaa Asp Val Ile Tyr Ser Leu Ile Ile Arg Arg Lys Pro 
225                 230                 235                 240 


Leu Phe Tyr Val Ile Asn Ile Ile Val Pro Cys Val Leu Ile Ser Gly 
                245                 250                 255     


Leu Val Leu Leu Ala Tyr Phe Leu Pro Ala Gln Ala Gly Gly Gln Lys 
            260                 265                 270         


Cys Xaa Val Ser Ile Asn Val Leu Leu Ala Gln Xaa Val Phe Leu Phe 
        275                 280                 285             


Leu Ile Ala Gln Lys Ile Pro Glu Xaa Ser Leu Ser Val Pro Leu Leu 
    290                 295                 300                 


Gly Arg Phe Leu Ile Phe Val Met Val Val Ala Xaa Leu Ile Val Met 
305                 310                 315                 320 


Asn Cys Val Ile Val Leu Asn Val Ser Gln Arg Xaa Pro Xaa Xaa His 
                325                 330                 335     


Ala Met Ser Pro Arg Leu Arg His Val Leu Leu Glu Leu Leu Pro Arg 
            340                 345                 350         


Leu Leu Gly Ser Pro Pro Pro Pro Glu Ala Pro Arg Ala Ala Ser Pro 
        355                 360                 365             


Pro Arg Arg Ala Ser Ser Val Gly Leu Leu Leu Arg Ala Glu Glu Leu 
    370                 375                 380                 


Ile Leu Lys Lys Pro Arg Ser Glu Leu Val Phe Glu Gly Gln Arg His 
385                 390                 395                 400 


Arg Gln Gly Xaa Trp Xaa Ala Ala Phe Cys Gln Ser Leu Gly Ala Ala 
                405                 410                 415     


Ala Pro Glu Val Arg Cys Cys Val Asp Ala Val Asn Phe Val Ala Glu 
            420                 425                 430         


Ser Xaa Arg Asp Gln Glu Ala Xaa Gly Glu Glu Val Ser Asp Trp Val 
        435                 440                 445             


Arg Met Gly Asn Ala Leu Asp Asn Ile Cys Phe Trp Ala Ala Leu Val 
    450                 455                 460                 


Leu Phe Ser Val Gly Ser Ser Leu Ile Phe Leu Gly Ala Tyr Phe Asn 
465                 470                 475                 480 


Arg Val Pro Asp Leu Pro Tyr Ala Pro Cys Ile Gln Pro 
                485                 490             


<210> 6220
<211> 465
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<400> 6220
Met His Gly Gly Gln Gly Pro Leu Leu Leu Leu Leu Leu Leu Ala Val 
1               5                   10                  15      


Cys Leu Gly Ala Gln Gly Arg Asn Gln Glu Glu Arg Leu Leu Ala Asp 
            20                  25                  30          


Leu Met Gln Asn Tyr Asp Pro Asn Leu Arg Pro Ala Glu Arg Asp Ser 
        35                  40                  45              


Asp Val Val Asn Val Ser Leu Lys Leu Xaa Leu Xaa Asn Leu Ile Ser 
    50                  55                  60                  


Leu Asn Glu Arg Glu Glu Ala Leu Xaa Xaa Asn Val Trp Ile Glu Met 
65                  70                  75                  80  


Gln Trp Cys Asp Tyr Arg Leu Arg Trp Asp Pro Arg Asp Tyr Glu Gly 
                85                  90                  95      


Leu Trp Val Leu Arg Val Pro Ser Xaa Met Val Trp Arg Pro Asp Ile 
            100                 105                 110         


Val Leu Glu Asn Lys Ser Gln Xaa Tyr Ser Xaa Asn Glu Ile Asp Leu 
        115                 120                 125             


Gln Leu Ser Gln Glu Asp Gly Gln Xaa Ile Glu Trp Ile Phe Ile Asp 
    130                 135                 140                 


Pro Glu Ala Phe Xaa Glu Asn Gly Glu Trp Ala Ile Gln His Arg Pro 
145                 150                 155                 160 


Ala Lys Met Leu Leu Asp Pro Ala Ala Pro Ala Gln Glu Ala Gly His 
                165                 170                 175     


Gln Lys Val Val Phe Tyr Leu Leu Ile Gln Arg Lys Pro Leu Phe Tyr 
            180                 185                 190         


Val Ile Asn Ile Ile Ala Pro Cys Val Leu Ile Ser Ser Val Ala Ile 
        195                 200                 205             


Leu Ile His Phe Leu Pro Ala Lys Ala Gly Gly Gln Lys Cys Xaa Val 
    210                 215                 220                 


Ala Ile Asn Val Leu Leu Ala Gln Xaa Val Phe Leu Phe Leu Val Ala 
225                 230                 235                 240 


Lys Lys Val Pro Glu Xaa Ser Gln Ala Val Pro Leu Ile Ser Lys Tyr 
                245                 250                 255     


Leu Xaa Phe Leu Leu Val Val Xaa Ile Leu Ile Val Val Asn Ala Val 
            260                 265                 270         


Val Val Leu Asn Val Ser Leu Arg Ser Pro His Xaa His Ser Met Ala 
        275                 280                 285             


Arg Gly Val Arg Lys Val Phe Leu Arg Leu Leu Pro Gln Leu Leu Arg 
    290                 295                 300                 


Met His Val Arg Pro Leu Ala Pro Ala Ala Val Gln Asp Xaa Gln Ser 
305                 310                 315                 320 


Arg Leu Gln Asn Gly Ser Ser Gly Trp Ser Ile Xaa Xaa Gly Glu Glu 
                325                 330                 335     


Val Ala Leu Cys Leu Pro Arg Ser Glu Leu Leu Phe Gln Gln Trp Gln 
            340                 345                 350         


Arg Gln Gly Leu Val Ala Ala Ala Leu Glu Lys Leu Glu Lys Gly Pro 
        355                 360                 365             


Glu Leu Gly Leu Ser Gln Phe Cys Gly Ser Leu Lys Gln Ala Ala Pro 
    370                 375                 380                 


Ala Ile Gln Ala Cys Val Glu Ala Cys Asn Leu Ile Ala Cys Ala Arg 
385                 390                 395                 400 


His Gln Gln Ser His Phe Asp Asn Gly Asn Glu Glu Trp Phe Leu Val 
                405                 410                 415     


Gly Arg Val Leu Asp Arg Val Cys Phe Leu Ala Met Leu Ser Leu Phe 
            420                 425                 430         


Ile Cys Gly Xaa Ala Gly Ile Phe Leu Met Ala His Tyr Asn Arg Val 
        435                 440                 445             


Pro Ala Leu Pro Phe Pro Gly Asp Pro Arg Pro Tyr Leu Pro Ser Pro 
    450                 455                 460                 


Asp 
465 


<210> 6221
<211> 517
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<400> 6221
Met His Gly Gly Gln Gly Pro Leu Leu Leu Leu Leu Leu Leu Ala Val 
1               5                   10                  15      


Cys Leu Gly Ala Gln Gly Arg Asn Gln Glu Glu Arg Leu Leu Ala Asp 
            20                  25                  30          


Leu Met Gln Asn Tyr Asp Pro Asn Leu Arg Pro Ala Glu Arg Asp Ser 
        35                  40                  45              


Asp Val Val Asn Val Ser Leu Lys Leu Xaa Leu Xaa Asn Leu Ile Ser 
    50                  55                  60                  


Leu Asn Glu Arg Glu Glu Ala Leu Xaa Xaa Asn Val Trp Ile Glu Met 
65                  70                  75                  80  


Gln Trp Cys Asp Tyr Arg Leu Arg Trp Asp Pro Arg Asp Tyr Glu Gly 
                85                  90                  95      


Leu Trp Val Leu Arg Val Pro Ser Xaa Met Val Trp Arg Pro Asp Ile 
            100                 105                 110         


Val Leu Glu Asn Asn Val Asp Gly Val Phe Glu Val Ala Leu Tyr Cys 
        115                 120                 125             


Asn Val Leu Val Ser Pro Asp Gly Cys Ile Tyr Trp Leu Pro Pro Ala 
    130                 135                 140                 


Ile Phe Arg Ser Ala Cys Ser Ile Ser Val Xaa Tyr Phe Pro Phe Asp 
145                 150                 155                 160 


Trp Gln Asn Cys Ser Leu Ile Phe Gln Ser Gln Xaa Tyr Ser Xaa Asn 
                165                 170                 175     


Glu Ile Asp Leu Gln Leu Ser Gln Glu Asp Gly Gln Xaa Ile Glu Trp 
            180                 185                 190         


Ile Phe Ile Asp Pro Glu Ala Phe Xaa Glu Asn Gly Glu Trp Ala Ile 
        195                 200                 205             


Gln His Arg Pro Ala Lys Met Leu Leu Asp Pro Ala Ala Pro Ala Gln 
    210                 215                 220                 


Glu Ala Gly His Gln Lys Val Val Phe Tyr Leu Leu Ile Gln Arg Lys 
225                 230                 235                 240 


Pro Leu Phe Tyr Val Ile Asn Ile Ile Ala Pro Cys Val Leu Ile Ser 
                245                 250                 255     


Ser Val Ala Ile Leu Ile His Phe Leu Pro Ala Lys Ala Gly Gly Gln 
            260                 265                 270         


Lys Cys Xaa Val Ala Ile Asn Val Leu Leu Ala Gln Xaa Val Phe Leu 
        275                 280                 285             


Phe Leu Val Ala Lys Lys Val Pro Glu Xaa Ser Gln Ala Val Pro Leu 
    290                 295                 300                 


Ile Ser Lys Tyr Leu Xaa Phe Leu Leu Val Val Xaa Ile Leu Ile Val 
305                 310                 315                 320 


Val Asn Ala Val Val Val Leu Asn Val Ser Leu Arg Ser Pro His Xaa 
                325                 330                 335     


His Ser Met Ala Arg Gly Val Arg Lys Val Phe Leu Arg Leu Leu Pro 
            340                 345                 350         


Gln Leu Leu Arg Met His Val Arg Pro Leu Ala Pro Ala Ala Val Gln 
        355                 360                 365             


Asp Xaa Gln Ser Arg Leu Gln Asn Gly Ser Ser Gly Trp Ser Ile Xaa 
    370                 375                 380                 


Xaa Gly Glu Glu Val Ala Leu Cys Leu Pro Arg Ser Glu Leu Leu Phe 
385                 390                 395                 400 


Gln Gln Trp Gln Arg Gln Gly Leu Val Ala Ala Ala Leu Glu Lys Leu 
                405                 410                 415     


Glu Lys Gly Pro Glu Leu Gly Leu Ser Gln Phe Cys Gly Ser Leu Lys 
            420                 425                 430         


Gln Ala Ala Pro Ala Ile Gln Ala Cys Val Glu Ala Cys Asn Leu Ile 
        435                 440                 445             


Ala Cys Ala Arg His Gln Gln Ser His Phe Asp Asn Gly Asn Glu Glu 
    450                 455                 460                 


Trp Phe Leu Val Gly Arg Val Leu Asp Arg Val Cys Phe Leu Ala Met 
465                 470                 475                 480 


Leu Ser Leu Phe Ile Cys Gly Xaa Ala Gly Ile Phe Leu Met Ala His 
                485                 490                 495     


Tyr Asn Arg Val Pro Ala Leu Pro Phe Pro Gly Asp Pro Arg Pro Tyr 
            500                 505                 510         


Leu Pro Ser Pro Asp 
        515         


<210> 6222
<211> 347
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<400> 6222
Met Lys Pro Ala Leu Leu Glu Val Met Arg Met Asn Arg Ile Cys Arg 
1               5                   10                  15      


Met Val Leu Ala Xaa Cys Leu Gly Ser Phe Ile Leu Val Ile Phe Tyr 
            20                  25                  30          


Phe Gln Ile Met Arg Arg Asn Pro Phe Gly Val Asp Ile Cys Cys Arg 
        35                  40                  45              


Lys Gly Ser Arg Ser Pro Leu Gln Glu Leu Tyr Asn Pro Ile Gln Leu 
    50                  55                  60                  


Glu Leu Ser Asn Xaa Ala Val Leu His Gln Met Arg Arg Asp Gln Val 
65                  70                  75                  80  


Xaa Asp Xaa Cys Arg Ala Asn Ser Ala Xaa Ser Arg Lys Arg Arg Val 
                85                  90                  95      


Leu Xaa Pro Asn Asp Leu Lys His Leu Val Val Asp Glu Asp His Glu 
            100                 105                 110         


Leu Ile Tyr Cys Tyr Val Pro Lys Val Ala Cys Xaa Asn Trp Lys Arg 
        115                 120                 125             


Leu Met Met Val Leu Xaa Gly Arg Gly Lys Tyr Ser Asp Pro Met Glu 
    130                 135                 140                 


Ile Pro Ala Asn Glu Ala His Val Ser Ala Asn Leu Lys Xaa Leu Asn 
145                 150                 155                 160 


Gln Tyr Ser Ile Pro Glu Ile Asn His Arg Leu Lys Ser Tyr Met Lys 
                165                 170                 175     


Phe Leu Phe Val Arg Glu Pro Phe Glu Arg Leu Val Ser Ala Tyr Arg 
            180                 185                 190         


Asn Lys Phe Xaa Gln Lys Tyr Asn Ile Ser Phe His Lys Arg Tyr Gly 
        195                 200                 205             


Xaa Lys Ile Ile Lys Arg Gln Arg Lys Asn Ala Xaa Gln Glu Ala Leu 
    210                 215                 220                 


Arg Lys Gly Asp Asp Val Lys Phe Glu Glu Phe Val Ala Tyr Leu Ile 
225                 230                 235                 240 


Asp Pro His Xaa Gln Arg Glu Glu Pro Phe Asn Glu His Trp Gln Xaa 
                245                 250                 255     


Val Tyr Ser Leu Cys His Pro Cys His Ile His Tyr Asp Leu Val Gly 
            260                 265                 270         


Lys Tyr Glu Xaa Leu Glu Glu Asp Ser Asn Tyr Val Leu Gln Leu Ala 
        275                 280                 285             


Gly Val Gly Ser Tyr Leu Lys Phe Pro Xaa Tyr Ala Lys Ser Xaa Arg 
    290                 295                 300                 


Xaa Xaa Asp Glu Met Xaa Xaa Glu Phe Phe Gln Asn Ile Ser Ser Glu 
305                 310                 315                 320 


His Gln Xaa Gln Leu Tyr Glu Val Tyr Lys Leu Asp Phe Leu Met Phe 
                325                 330                 335     


Asn Tyr Ser Val Pro Ser Tyr Leu Lys Leu Glu 
            340                 345         


<210> 6223
<211> 72
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<400> 6223
Met Lys Pro Ala Leu Leu Glu Val Met Arg Met Asn Arg Ile Cys Arg 
1               5                   10                  15      


Met Val Leu Ala Xaa Cys Leu Gly Ser Phe Ile Leu Val Ile Phe Tyr 
            20                  25                  30          


Phe Gln Ile Met Arg Arg Asn Pro Phe Gly Val Asp Ile Cys Cys Arg 
        35                  40                  45              


Lys Gly Ser Arg Ser Pro Leu Gln Glu Leu Tyr Asn Pro Ile Gln Val 
    50                  55                  60                  


Ser Phe Lys His Ser Val Ser Met 
65                  70          


<210> 6224
<211> 352
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<400> 6224
Met Lys Pro Ala Leu Leu Glu Val Met Arg Met Asn Arg Ile Cys Arg 
1               5                   10                  15      


Met Val Leu Ala Xaa Cys Leu Gly Ser Phe Ile Leu Val Ile Phe Tyr 
            20                  25                  30          


Phe Gln Ser Met Leu His Pro Val Met Arg Arg Asn Pro Phe Gly Val 
        35                  40                  45              


Asp Ile Cys Cys Arg Lys Gly Ser Arg Ser Pro Leu Gln Glu Leu Tyr 
    50                  55                  60                  


Asn Pro Ile Gln Leu Glu Leu Ser Asn Xaa Ala Val Leu His Gln Met 
65                  70                  75                  80  


Arg Arg Asp Gln Val Xaa Asp Xaa Cys Arg Ala Asn Ser Ala Xaa Ser 
                85                  90                  95      


Arg Lys Arg Arg Val Leu Xaa Pro Asn Asp Leu Lys His Leu Val Val 
            100                 105                 110         


Asp Glu Asp His Glu Leu Ile Tyr Cys Tyr Val Pro Lys Val Ala Cys 
        115                 120                 125             


Xaa Asn Trp Lys Arg Leu Met Met Val Leu Xaa Gly Arg Gly Lys Tyr 
    130                 135                 140                 


Ser Asp Pro Met Glu Ile Pro Ala Asn Glu Ala His Val Ser Ala Asn 
145                 150                 155                 160 


Leu Lys Xaa Leu Asn Gln Tyr Ser Ile Pro Glu Ile Asn His Arg Leu 
                165                 170                 175     


Lys Ser Tyr Met Lys Phe Leu Phe Val Arg Glu Pro Phe Glu Arg Leu 
            180                 185                 190         


Val Ser Ala Tyr Arg Asn Lys Phe Xaa Gln Lys Tyr Asn Ile Ser Phe 
        195                 200                 205             


His Lys Arg Tyr Gly Xaa Lys Ile Ile Lys Arg Gln Arg Lys Asn Ala 
    210                 215                 220                 


Xaa Gln Glu Ala Leu Arg Lys Gly Asp Asp Val Lys Phe Glu Glu Phe 
225                 230                 235                 240 


Val Ala Tyr Leu Ile Asp Pro His Xaa Gln Arg Glu Glu Pro Phe Asn 
                245                 250                 255     


Glu His Trp Gln Xaa Val Tyr Ser Leu Cys His Pro Cys His Ile His 
            260                 265                 270         


Tyr Asp Leu Val Gly Lys Tyr Glu Xaa Leu Glu Glu Asp Ser Asn Tyr 
        275                 280                 285             


Val Leu Gln Leu Ala Gly Val Gly Ser Tyr Leu Lys Phe Pro Xaa Tyr 
    290                 295                 300                 


Ala Lys Ser Xaa Arg Xaa Xaa Asp Glu Met Xaa Xaa Glu Phe Phe Gln 
305                 310                 315                 320 


Asn Ile Ser Ser Glu His Gln Xaa Gln Leu Tyr Glu Val Tyr Lys Leu 
                325                 330                 335     


Asp Phe Leu Met Phe Asn Tyr Ser Val Pro Ser Tyr Leu Lys Leu Glu 
            340                 345                 350         


<210> 6225
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<400> 6225
Met Lys Pro Ala Leu Leu Glu Val Met Arg Met Asn Arg Ile Cys Arg 
1               5                   10                  15      


Met Val Leu Ala Xaa Cys Leu Gly Ser Phe Ile Leu Val Ile Phe Tyr 
            20                  25                  30          


Phe Gln Ser Met Leu His Pro Val Met Arg Arg Asn Pro Phe Gly Val 
        35                  40                  45              


Asp Ile Cys Cys Arg Lys Gly Ser Arg Ser Pro Leu Gln Glu Leu Tyr 
    50                  55                  60                  


Asn Pro Ile Gln Val Ser Phe Lys His Ser Val Ser Met 
65                  70                  75          


<210> 6226
<211> 158
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<400> 6226
Met Arg Arg Asn Pro Phe Gly Val Asp Ile Cys Cys Arg Lys Gly Ser 
1               5                   10                  15      


Arg Ser Pro Leu Gln Glu Leu Tyr Asn Pro Ile Gln Leu Glu Leu Ser 
            20                  25                  30          


Asn Xaa Ala Val Leu His Gln Met Arg Arg Asp Gln Val Xaa Asp Xaa 
        35                  40                  45              


Cys Arg Ala Asn Ser Ala Xaa Ser Arg Lys Arg Arg Val Leu Xaa Pro 
    50                  55                  60                  


Asn Asp Leu Lys His Leu Val Val Asp Glu Asp His Glu Leu Ile Tyr 
65                  70                  75                  80  


Cys Tyr Val Pro Lys Val Ala Cys Xaa Asn Trp Lys Arg Leu Met Met 
                85                  90                  95      


Val Leu Xaa Gly Arg Gly Lys Tyr Ser Asp Pro Met Glu Ile Pro Ala 
            100                 105                 110         


Asn Glu Ala His Val Ser Ala Asn Leu Lys Xaa Leu Asn Gln Tyr Ser 
        115                 120                 125             


Ile Pro Glu Ile Asn His Arg Leu Lys Ser Tyr Met Lys Phe Leu Phe 
    130                 135                 140                 


Val Arg Glu Pro Phe Glu Arg Leu Val Ser Ala Tyr Arg Asn 
145                 150                 155             


<210> 6227
<211> 386
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<400> 6227
Met Leu Leu Pro Lys Lys Met Lys Leu Leu Leu Phe Leu Val Ser Gln 
1               5                   10                  15      


Met Ala Ile Leu Ala Leu Phe Phe His Met Tyr Ser His Asn Ile Ser 
            20                  25                  30          


Ser Leu Ser Met Lys Ala Gln Pro Glu Arg Met His Val Leu Val Leu 
        35                  40                  45              


Ser Ser Trp Arg Ser Gly Ser Ser Phe Val Gly Gln Leu Phe Gly Gln 
    50                  55                  60                  


His Pro Asp Val Phe Tyr Leu Met Glu Pro Ala Trp His Val Trp Met 
65                  70                  75                  80  


Xaa Phe Lys Gln Ser Xaa Ala Trp Met Leu His Met Ala Val Arg Asp 
                85                  90                  95      


Leu Ile Arg Ala Val Phe Leu Cys Asp Met Ser Val Phe Asp Ala Tyr 
            100                 105                 110         


Met Glu Pro Gly Pro Arg Arg Gln Ser Ser Leu Phe Gln Trp Glu Asn 
        115                 120                 125             


Ser Arg Ala Leu Cys Ser Ala Pro Ala Cys Asp Ile Ile Pro Gln Asp 
    130                 135                 140                 


Glu Ile Ile Pro Arg Ala His Cys Arg Leu Leu Cys Ser Gln Gln Pro 
145                 150                 155                 160 


Phe Glu Val Val Glu Lys Ala Cys Arg Ser Tyr Ser His Val Val Leu 
                165                 170                 175     


Lys Glu Val Arg Phe Phe Asn Leu Gln Ser Leu Tyr Pro Leu Leu Lys 
            180                 185                 190         


Asp Pro Ser Leu Asn Leu His Ile Val His Leu Val Arg Asp Pro Arg 
        195                 200                 205             


Ala Val Phe Arg Ser Arg Glu Arg Xaa Lys Gly Asp Leu Met Ile Asp 
    210                 215                 220                 


Ser Arg Ile Val Met Gly Gln His Glu Gln Lys Leu Lys Lys Glu Asp 
225                 230                 235                 240 


Gln Pro Tyr Tyr Val Met Gln Val Ile Cys Gln Ser Gln Leu Glu Ile 
                245                 250                 255     


Tyr Lys Xaa Ile Gln Ser Leu Pro Lys Ala Leu Gln Glu Arg Tyr Leu 
            260                 265                 270         


Leu Val Arg Tyr Glu Asp Leu Ala Arg Ala Pro Val Ala Gln Xaa Ser 
        275                 280                 285             


Arg Met Tyr Glu Phe Val Gly Leu Glu Phe Leu Pro His Leu Gln Xaa 
    290                 295                 300                 


Trp Val His Asn Ile Xaa Arg Gly Lys Gly Met Gly Asp His Ala Phe 
305                 310                 315                 320 


His Xaa Asn Ala Arg Asp Ala Leu Asn Val Ser Gln Ala Trp Arg Trp 
                325                 330                 335     


Ser Leu Pro Tyr Glu Lys Val Ser Arg Leu Gln Lys Ala Cys Gly Asp 
            340                 345                 350         


Ala Met Asn Leu Leu Gly Tyr Arg His Val Arg Ser Glu Gln Glu Gln 
        355                 360                 365             


Arg Asn Leu Leu Leu Asp Leu Leu Ser Xaa Trp Xaa Val Pro Glu Gln 
    370                 375                 380                 


Ile His 
385     


<210> 6228
<211> 802
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<400> 6228
Met Ala Ala Arg Gly Arg Arg Ala Trp Leu Ser Val Leu Leu Gly Leu 
1               5                   10                  15      


Val Leu Gly Phe Val Leu Ala Ser Arg Leu Val Leu Pro Arg Ala Ser 
            20                  25                  30          


Glu Leu Lys Arg Ala Gly Pro Arg Arg Arg Ala Ser Pro Glu Gly Cys 
        35                  40                  45              


Arg Ser Gly Gln Ala Ala Ala Ser Gln Ala Gly Gly Ala Arg Gly Asp 
    50                  55                  60                  


Ala Arg Gly Ala Gln Leu Trp Pro Pro Gly Ser Asp Pro Asp Gly Gly 
65                  70                  75                  80  


Pro Arg Asp Arg Asn Phe Leu Phe Val Gly Val Met Xaa Ala Gln Lys 
                85                  90                  95      


Tyr Leu Gln Xaa Arg Ala Val Ala Ala Tyr Arg Xaa Trp Ser Lys Xaa 
            100                 105                 110         


Ile Pro Gly Lys Val Gln Phe Phe Ser Ser Glu Gly Ser Asp Xaa Ser 
        115                 120                 125             


Val Pro Ile Pro Val Val Pro Leu Arg Gly Val Asp Asp Ser Tyr Pro 
    130                 135                 140                 


Pro Gln Lys Lys Ser Phe Met Met Leu Lys Tyr Met His Asp His Tyr 
145                 150                 155                 160 


Leu Asp Lys Tyr Glu Trp Phe Met Arg Ala Asp Asp Asp Val Tyr Ile 
                165                 170                 175     


Lys Gly Asp Arg Leu Glu Asn Phe Leu Arg Ser Leu Asn Ser Ser Glu 
            180                 185                 190         


Pro Leu Phe Leu Gly Gln Xaa Gly Leu Gly Xaa Xaa Glu Glu Met Gly 
        195                 200                 205             


Lys Leu Ala Leu Glu Pro Gly Glu Asn Phe Cys Met Gly Gly Pro Gly 
    210                 215                 220                 


Val Ile Met Ser Arg Glu Val Leu Arg Arg Met Val Pro His Ile Gly 
225                 230                 235                 240 


Lys Cys Leu Arg Glu Met Tyr Xaa Xaa His Glu Asp Val Glu Val Gly 
                245                 250                 255     


Arg Cys Val Arg Arg Phe Ala Gly Val Gln Cys Val Trp Ser Tyr Glu 
            260                 265                 270         


Met Gln Gln Leu Phe Tyr Glu Asn Tyr Glu Gln Asn Lys Lys Gly Tyr 
        275                 280                 285             


Ile Arg Asp Leu His Asn Ser Lys Ile His Gln Ala Ile Xaa Leu His 
    290                 295                 300                 


Pro Asn Lys Asn Pro Pro Tyr Gln Tyr Arg Leu His Ser Tyr Met Leu 
305                 310                 315                 320 


Ser Arg Lys Ile Ser Glu Leu Arg His Arg Xaa Ile Gln Leu His Arg 
                325                 330                 335     


Glu Ile Val Leu Met Ser Lys Tyr Ser Asn Xaa Glu Ile His Lys Glu 
            340                 345                 350         


Asp Leu Gln Leu Gly Ile Pro Pro Ser Phe Met Arg Phe Gln Pro Arg 
        355                 360                 365             


Gln Arg Glu Glu Ile Leu Glu Trp Glu Phe Leu Xaa Gly Lys Tyr Leu 
    370                 375                 380                 


Tyr Ser Ala Val Asp Gly Gln Pro Pro Arg Arg Gly Met Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Glu Ala Leu Asp Asp Ile Val Met Gln Val Met Glu Met Ile 
                405                 410                 415     


Asn Ala Asn Ala Lys Xaa Arg Gly Arg Ile Ile Asp Phe Lys Glu Ile 
            420                 425                 430         


Gln Tyr Gly Tyr Arg Arg Val Asn Pro Met Tyr Gly Ala Glu Tyr Ile 
        435                 440                 445             


Leu Asp Leu Leu Leu Leu Tyr Lys Lys His Lys Gly Lys Lys Met Xaa 
    450                 455                 460                 


Val Pro Val Arg Arg His Ala Tyr Leu Gln Gln Xaa Phe Ser Lys Ile 
465                 470                 475                 480 


Gln Phe Val Glu His Glu Glu Leu Asp Ala Gln Glu Leu Ala Lys Arg 
                485                 490                 495     


Ile Asn Gln Glu Ser Gly Ser Leu Ser Phe Leu Ser Asn Ser Leu Lys 
            500                 505                 510         


Lys Leu Val Pro Phe Gln Leu Pro Gly Ser Lys Ser Glu His Lys Glu 
        515                 520                 525             


Pro Lys Asp Lys Lys Ile Asn Ile Leu Ile Pro Leu Ser Gly Arg Phe 
    530                 535                 540                 


Asp Met Phe Val Arg Phe Met Gly Asn Phe Glu Lys Xaa Cys Leu Ile 
545                 550                 555                 560 


Pro Asn Gln Asn Val Lys Leu Val Val Leu Leu Phe Asn Ser Asp Ser 
                565                 570                 575     


Asn Pro Asp Lys Ala Lys Gln Val Glu Leu Met Arg Asp Tyr Arg Ile 
            580                 585                 590         


Lys Tyr Pro Lys Ala Asp Met Gln Ile Leu Pro Val Ser Gly Glu Phe 
        595                 600                 605             


Ser Arg Ala Leu Ala Leu Glu Val Gly Ser Ser Gln Phe Asn Asn Glu 
    610                 615                 620                 


Ser Leu Leu Phe Phe Cys Asp Val Asp Leu Val Phe Xaa Xaa Glu Phe 
625                 630                 635                 640 


Leu Gln Arg Cys Arg Ala Asn Xaa Val Leu Gly Gln Gln Ile Tyr Phe 
                645                 650                 655     


Pro Ile Ile Phe Ser Gln Tyr Asp Pro Lys Ile Val Tyr Ser Gly Lys 
            660                 665                 670         


Val Pro Ser Asp Asn His Phe Ala Phe Xaa Gln Lys Xaa Gly Phe Trp 
        675                 680                 685             


Arg Asn Tyr Gly Phe Gly Ile Xaa Cys Ile Tyr Lys Gly Asp Leu Val 
    690                 695                 700                 


Arg Val Gly Gly Phe Asp Val Ser Ile Gln Gly Trp Gly Leu Glu Asp 
705                 710                 715                 720 


Val Asp Leu Phe Asn Lys Val Val Gln Ala Gly Leu Lys Xaa Phe Arg 
                725                 730                 735     


Ser Gln Glu Val Gly Val Val His Val His His Pro Val Phe Cys Asp 
            740                 745                 750         


Pro Asn Leu Asp Pro Lys Gln Tyr Lys Met Cys Leu Gly Ser Lys Ala 
        755                 760                 765             


Ser Xaa Tyr Gly Ser Xaa Gln Gln Leu Ala Glu Met Trp Leu Glu Lys 
    770                 775                 780                 


Asn Asp Pro Ser Tyr Ser Lys Ser Ser Asn Asn Asn Gly Ser Val Arg 
785                 790                 795                 800 


Xaa Ala 
        


<210> 6229
<211> 745
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<400> 6229
Met Glu Arg Pro Pro Gly Leu Arg Pro Gly Ala Gly Gly Pro Trp Glu 
1               5                   10                  15      


Met Arg Glu Arg Leu Gly Xaa Gly Gly Phe Gly Asn Val Cys Leu Tyr 
            20                  25                  30          


Gln His Arg Glu Leu Asp Leu Lys Ile Ala Ile Lys Ser Cys Arg Leu 
        35                  40                  45              


Glu Leu Ser Xaa Lys Asn Arg Glu Arg Trp Cys His Glu Ile Gln Ile 
    50                  55                  60                  


Met Lys Lys Leu Asn His Ala Asn Val Val Lys Ala Cys Asp Val Pro 
65                  70                  75                  80  


Glu Glu Leu Asn Ile Leu Ile His Asp Val Pro Leu Leu Ala Met Glu 
                85                  90                  95      


Tyr Cys Ser Gly Gly Asp Leu Arg Lys Leu Leu Asn Lys Pro Glu Asn 
            100                 105                 110         


Cys Cys Gly Leu Lys Glu Ser Gln Ile Leu Ser Leu Leu Ser Asp Ile 
        115                 120                 125             


Gly Ser Gly Ile Arg Tyr Leu His Glu Asn Lys Ile Ile His Arg Asp 
    130                 135                 140                 


Leu Lys Pro Glu Asn Ile Val Leu Gln Asp Val Gly Gly Lys Ile Ile 
145                 150                 155                 160 


His Lys Ile Ile Asp Leu Gly Tyr Ala Lys Asp Val Asp Gln Gly Ser 
                165                 170                 175     


Leu Cys Xaa Ser Phe Val Gly Xaa Leu Gln Tyr Leu Ala Pro Glu Leu 
            180                 185                 190         


Phe Glu Asn Lys Pro Tyr Xaa Ala Xaa Val Asp Tyr Trp Ser Phe Gly 
        195                 200                 205             


Xaa Met Val Phe Glu Cys Ile Ala Gly Tyr Arg Pro Phe Leu His His 
    210                 215                 220                 


Leu Gln Pro Phe Xaa Trp His Glu Lys Ile Lys Lys Lys Asp Pro Lys 
225                 230                 235                 240 


Cys Ile Phe Ala Cys Glu Glu Met Ser Gly Glu Val Arg Phe Ser Ser 
                245                 250                 255     


His Leu Pro Gln Pro Asn Ser Leu Cys Ser Leu Val Val Glu Pro Met 
            260                 265                 270         


Glu Asn Trp Leu Gln Leu Met Leu Asn Trp Asp Pro Gln Gln Arg Gly 
        275                 280                 285             


Gly Pro Val Asp Leu Xaa Leu Lys Gln Pro Arg Cys Phe Val Leu Met 
    290                 295                 300                 


Asp His Ile Leu Asn Leu Lys Ile Val His Ile Leu Asn Met Xaa Ser 
305                 310                 315                 320 


Ala Lys Ile Ile Ser Phe Leu Leu Pro Pro Asp Glu Ser Leu His Ser 
                325                 330                 335     


Leu Gln Ser Arg Ile Glu Arg Glu Xaa Gly Ile Asn Xaa Gly Ser Gln 
            340                 345                 350         


Glu Leu Leu Ser Glu Xaa Gly Ile Ser Leu Asp Pro Arg Lys Pro Ala 
        355                 360                 365             


Ser Gln Cys Val Leu Asp Gly Val Arg Gly Cys Asp Ser Tyr Met Val 
    370                 375                 380                 


Tyr Leu Phe Asp Lys Ser Lys Xaa Val Tyr Glu Gly Pro Phe Ala Ser 
385                 390                 395                 400 


Arg Ser Leu Ser Asp Cys Val Asn Tyr Ile Val Gln Asp Ser Lys Ile 
                405                 410                 415     


Gln Leu Pro Ile Ile Gln Leu Arg Lys Val Trp Ala Glu Ala Val His 
            420                 425                 430         


Tyr Val Ser Gly Leu Lys Glu Asp Tyr Ser Arg Leu Phe Gln Gly Gln 
        435                 440                 445             


Arg Ala Ala Met Leu Ser Leu Leu Arg Tyr Asn Ala Asn Leu Xaa Lys 
    450                 455                 460                 


Met Lys Asn Xaa Leu Ile Ser Ala Ser Gln Gln Leu Lys Ala Lys Leu 
465                 470                 475                 480 


Glu Phe Phe His Lys Ser Ile Gln Leu Asp Leu Glu Arg Tyr Ser Glu 
                485                 490                 495     


Gln Met Xaa Tyr Gly Ile Ser Ser Glu Lys Met Leu Lys Ala Trp Lys 
            500                 505                 510         


Glu Met Glu Glu Lys Ala Ile His Tyr Ala Glu Val Gly Val Ile Gly 
        515                 520                 525             


Tyr Leu Glu Asp Gln Ile Met Ser Leu His Ala Glu Ile Met Glu Leu 
    530                 535                 540                 


Gln Lys Ser Pro Tyr Gly Arg Arg Gln Gly Asp Leu Met Glu Ser Leu 
545                 550                 555                 560 


Glu Gln Arg Ala Ile Asp Leu Tyr Lys Gln Leu Lys His Arg Pro Ser 
                565                 570                 575     


Asp His Ser Tyr Ser Asp Ser Xaa Glu Met Val Lys Ile Ile Val His 
            580                 585                 590         


Xaa Val Gln Ser Gln Asp Arg Val Leu Lys Glu Leu Phe Gly His Leu 
        595                 600                 605             


Ser Lys Leu Leu Gly Cys Lys Gln Lys Ile Ile Asp Leu Leu Pro Lys 
    610                 615                 620                 


Val Glu Val Ala Leu Ser Asn Ile Lys Glu Ala Asp Asn Xaa Val Met 
625                 630                 635                 640 


Phe Met Gln Gly Lys Arg Gln Lys Glu Ile Trp His Leu Leu Lys Ile 
                645                 650                 655     


Ala Cys Xaa Gln Ser Ser Ala Arg Ser Leu Val Gly Ser Ser Leu Glu 
            660                 665                 670         


Gly Ala Val Xaa Pro Gln Xaa Ser Ala Trp Leu Pro Pro Xaa Ser Ala 
        675                 680                 685             


Glu His Asp His Ser Leu Ser Cys Val Val Xaa Pro Gln Asp Gly Glu 
    690                 695                 700                 


Xaa Ser Ala Gln Met Ile Glu Glu Asn Leu Asn Cys Leu Gly His Leu 
705                 710                 715                 720 


Ser Xaa Ile Ile His Glu Ala Asn Glu Glu Gln Gly Asn Ser Met Met 
                725                 730                 735     


Asn Leu Asp Trp Ser Trp Leu Xaa Glu 
            740                 745 


<210> 6230
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<400> 6230
Met Gly Gly Ser Gly Ser Arg Leu Ser Lys Glu Leu Leu Ala Glu Tyr 
1               5                   10                  15      


Gln Asp Leu Xaa Phe Leu Xaa Lys Gln Glu Ile Leu Leu Ala His Arg 
            20                  25                  30          


Arg Phe Cys Glu Leu Leu Pro Gln Glu Gln Arg Ser Val Glu Ser Ser 
        35                  40                  45              


Leu Arg Ala Gln Val Pro Phe Glu Gln Ile Leu Ser Leu Pro Glu Leu 
    50                  55                  60                  


Lys Ala Asn Pro Phe Lys Glu Arg Ile Cys Arg Val Phe Ser Xaa Ser 
65                  70                  75                  80  


Pro Ala Lys Asp Ser Leu Ser Phe Glu Asp Phe Leu Asp Leu Leu Ser 
                85                  90                  95      


Val Phe Ser Asp Xaa Ala Xaa Pro Asp Ile Lys Ser His Tyr Ala Phe 
            100                 105                 110         


Arg Ile Phe Asp Phe Asp Asp Asp Gly Xaa Leu Asn Arg Glu Asp Leu 
        115                 120                 125             


Ser Arg Leu Val Asn Cys Leu Xaa Gly Glu Gly Glu Asp Xaa Arg Leu 
    130                 135                 140                 


Ser Ala Ser Glu Met Lys Gln Leu Ile Asp Asn Ile Leu Glu Glu Ser 
145                 150                 155                 160 


Asp Ile Asp Arg Asp Gly Xaa Ile Asn Leu Ser Glu Phe Gln His Val 
                165                 170                 175     


Ile Ser Arg Ser Pro Asp Phe Ala Ser Ser Phe Lys Ile Val Leu 
            180                 185                 190     


<210> 6231
<211> 231
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<400> 6231
Met Gly Gly Ser Gly Ser Arg Leu Ser Lys Glu Leu Leu Ala Glu Tyr 
1               5                   10                  15      


Gln Asp Leu Xaa Phe Leu Xaa Lys Gln Glu Ile Leu Leu Ser Val Tyr 
            20                  25                  30          


Val Val Leu Ala Pro His Leu Val Asp Asn Glu Gln Gln Ala Arg Ser 
        35                  40                  45              


Gly Asn Glu His Xaa Gly Arg Pro Ile Ala Glu Asn Xaa Asp Ser Ser 
    50                  55                  60                  


Pro Leu Ser Xaa Arg Ala His Arg Arg Phe Cys Glu Leu Leu Pro Gln 
65                  70                  75                  80  


Glu Gln Arg Ser Val Glu Ser Ser Leu Arg Ala Gln Val Pro Phe Glu 
                85                  90                  95      


Gln Ile Leu Ser Leu Pro Glu Leu Lys Ala Asn Pro Phe Lys Glu Arg 
            100                 105                 110         


Ile Cys Arg Val Phe Ser Xaa Ser Pro Ala Lys Asp Ser Leu Ser Phe 
        115                 120                 125             


Glu Asp Phe Leu Asp Leu Leu Ser Val Phe Ser Asp Xaa Ala Xaa Pro 
    130                 135                 140                 


Asp Ile Lys Ser His Tyr Ala Phe Arg Ile Phe Asp Phe Asp Asp Asp 
145                 150                 155                 160 


Gly Xaa Leu Asn Arg Glu Asp Leu Ser Arg Leu Val Asn Cys Leu Xaa 
                165                 170                 175     


Gly Glu Gly Glu Asp Xaa Arg Leu Ser Ala Ser Glu Met Lys Gln Leu 
            180                 185                 190         


Ile Asp Asn Ile Leu Glu Glu Ser Asp Ile Asp Arg Asp Gly Xaa Ile 
        195                 200                 205             


Asn Leu Ser Glu Phe Gln His Val Ile Ser Arg Ser Pro Asp Phe Ala 
    210                 215                 220                 


Ser Ser Phe Lys Ile Val Leu 
225                 230     


<210> 6232
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<400> 6232
Met Lys Pro Met Lys Lys Ala Cys Xaa Gly Leu Ser Gly Pro Gly Ser 
1               5                   10                  15      


Gly Ser Lys Ser Pro Pro Ala Xaa Arg Ala Lys Ala Leu Arg Arg Arg 
            20                  25                  30          


Gly Ala Gly Glu Gly Asp Lys Pro Glu Glu Glu Asp Asp Glu Ala Gln 
        35                  40                  45              


Gln Pro Gln Pro Gln Ser Gly Pro Glu Glu Ala Glu Glu Gly Glu Glu 
    50                  55                  60                  


Glu Glu Ala Glu Arg Gly Pro Gly Ala Glu Gly Pro Pro Leu Glu Leu 
65                  70                  75                  80  


His Pro Gly Asp Pro Ala Pro Gly Pro Ala Glu Asp Pro Lys Gly Asp 
                85                  90                  95      


Gly Glu Ala Gly Arg Trp Glu Pro Ser Leu Ser Arg Lys Xaa Ala Xaa 
            100                 105                 110         


Phe Lys Ser Arg Ala Pro Lys Lys Lys Tyr Val Glu Glu His Gly Ala 
        115                 120                 125             


Gly Ser Ser Gly Val Ala Gly Ala Pro Glu Glu Arg Val Arg Xaa Pro 
    130                 135                 140                 


<210> 6233
<211> 2514
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1138)..(1138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1193)..(1193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1214)..(1214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1237)..(1237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1252)..(1252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1302)..(1302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1322)..(1322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1330)..(1330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1344)..(1344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1369)..(1370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1413)..(1413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1465)..(1465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1476)..(1476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1492)..(1492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1497)..(1497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1539)..(1539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1579)..(1579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1591)..(1591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1602)..(1602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1613)..(1613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1618)..(1618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1622)..(1622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1647)..(1647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1661)..(1661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1668)..(1668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1670)..(1670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1676)..(1676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1699)..(1700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1732)..(1732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1757)..(1757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1768)..(1769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1774)..(1774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1779)..(1779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1781)..(1781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1789)..(1789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1792)..(1792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1876)..(1876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1882)..(1882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1894)..(1894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1899)..(1899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1911)..(1911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1914)..(1914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1928)..(1928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1937)..(1937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1939)..(1939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1944)..(1944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1952)..(1952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2001)..(2001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2011)..(2011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2029)..(2029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2032)..(2032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2034)..(2035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2040)..(2040)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2051)..(2051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2053)..(2053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2057)..(2057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2064)..(2064)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2068)..(2068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2124)..(2124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2135)..(2135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2145)..(2145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2147)..(2147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2149)..(2149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2164)..(2164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2171)..(2171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2198)..(2198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2225)..(2225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2234)..(2234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2248)..(2248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2281)..(2281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2287)..(2287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2304)..(2304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2314)..(2314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2332)..(2332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2344)..(2344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2348)..(2348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2350)..(2350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2372)..(2372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2396)..(2396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2429)..(2429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2431)..(2431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2447)..(2447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2449)..(2449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2456)..(2456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2466)..(2466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2474)..(2474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2509)..(2509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2512)..(2512)
<223> Selenocysteine

<400> 6233
Met Lys Pro Met Lys Lys Ala Cys Xaa Gly Leu Ser Gly Pro Gly Ser 
1               5                   10                  15      


Gly Ser Lys Ser Pro Pro Ala Xaa Arg Ala Lys Ala Leu Arg Arg Arg 
            20                  25                  30          


Gly Ala Gly Glu Gly Asp Lys Pro Glu Glu Glu Asp Asp Glu Ala Gln 
        35                  40                  45              


Gln Pro Gln Pro Gln Ser Gly Pro Glu Glu Ala Glu Glu Gly Glu Glu 
    50                  55                  60                  


Glu Glu Ala Glu Arg Gly Pro Gly Ala Glu Gly Pro Pro Leu Glu Leu 
65                  70                  75                  80  


His Pro Gly Asp Pro Ala Pro Gly Pro Ala Glu Asp Pro Lys Gly Asp 
                85                  90                  95      


Gly Glu Ala Gly Arg Trp Glu Pro Ser Leu Ser Arg Lys Xaa Ala Xaa 
            100                 105                 110         


Phe Lys Ser Arg Ala Pro Lys Lys Lys Tyr Val Glu Glu His Gly Ala 
        115                 120                 125             


Gly Ser Ser Gly Val Ala Gly Ala Pro Glu Glu Arg Val Arg Xaa Pro 
    130                 135                 140                 


Glu Glu Ala Ser Gly Leu Gly Val Pro Pro Arg Pro Pro Xaa Ser Xaa 
145                 150                 155                 160 


Arg Ser Ser Ser Xaa Asp Xaa Ala Ser Glu His Ser Ala Asp Leu Glu 
                165                 170                 175     


Asp Glu Pro Ala Glu Ala Cys Gly Pro Gly Pro Trp Pro Pro Gly Ser 
            180                 185                 190         


Xaa Ser Gly Ser Tyr Asp Leu Arg Gln Leu Arg Ser Gln Arg Val Leu 
        195                 200                 205             


Ala Arg Arg Gly Asp Gly Leu Phe Leu Pro Ala Val Val Arg Gln Val 
    210                 215                 220                 


Arg Arg Ser Gln Asp Leu Gly Val Gln Phe Pro Gly Asp Arg Ala Leu 
225                 230                 235                 240 


Xaa Phe Tyr Glu Gly Val Pro Gly Ala Gly Val Asp Val Val Leu Asp 
                245                 250                 255     


Ala Xaa Pro Pro Pro Gly Ala Leu Val Val Gly Xaa Ala Val Cys Xaa 
            260                 265                 270         


Cys Val Glu Pro Gly Val Ala Ala Tyr Arg Glu Gly Val Val Val Glu 
        275                 280                 285             


Val Ala Xaa Lys Pro Ala Ala Tyr Lys Val Arg Leu Ser Pro Gly Pro 
    290                 295                 300                 


Ser Ser Gln Pro Gly Leu Pro Gly Ser Leu Pro Gln Pro Pro Gln Pro 
305                 310                 315                 320 


Leu His Arg Glu Pro Glu Glu Ala Val Trp Val Ala Arg Ser Ser Leu 
                325                 330                 335     


Arg Leu Leu Arg Pro Pro Trp Glu Pro Glu Xaa Met Leu Arg Lys Pro 
            340                 345                 350         


Pro Xaa Gly Pro Glu Glu Glu Gln Ala Glu Pro Gly Ala Xaa Leu Pro 
        355                 360                 365             


Pro Cys Pro Ala Ala Leu Asp Pro Lys Gln Pro Glu Asp Ala Glu Val 
    370                 375                 380                 


Ser Lys Ile Ser Phe Gly Gly Asn Leu Gly Xaa His Cys Glu Glu Gly 
385                 390                 395                 400 


Glu Glu Lys His Pro Pro Ala Leu Gly Xaa Pro Ala Leu Leu Pro Leu 
                405                 410                 415     


Pro Pro Pro Gln Leu Leu Ser Pro Pro Pro Lys Ser Pro Ala Phe Val 
            420                 425                 430         


Gly Pro Gly Arg Pro Gly Glu Gln Pro Ser Pro Cys Gln Glu Gly Ser 
        435                 440                 445             


Gln Gly Gly Ser Arg Ser Ser Ser Val Ala Ser Leu Glu Lys Gly Xaa 
    450                 455                 460                 


Ala Pro Ala Ala Arg Ala Arg Xaa Pro Leu Xaa Ala Ala Gln Gln Lys 
465                 470                 475                 480 


Tyr Lys Lys Gly Asp Val Val Cys Xaa Pro Ser Gly Ile Arg Lys Lys 
                485                 490                 495     


Phe Asn Gly Lys Gln Trp Arg Arg Leu Cys Ser Arg Asp Gly Cys Met 
            500                 505                 510         


Lys Glu Ser Gln Arg Arg Gly Tyr Cys Ser Arg His Leu Ser Met Arg 
        515                 520                 525             


Xaa Lys Glu Met Glu Gly Leu Ala Asp Ser Gly Pro Gly Gly Ala Gly 
    530                 535                 540                 


Arg Pro Ala Ala Val Ala Ala Arg Glu Gly Ser Xaa Glu Phe Asp Trp 
545                 550                 555                 560 


Gly Asp Glu Xaa Ser Arg Asp Ser Glu Ala Ser Ser Val Ala Ala Arg 
                565                 570                 575     


Gly Asp Ser Arg Pro Arg Leu Val Ala Pro Ala Asp Leu Ser Arg Phe 
            580                 585                 590         


Glu Phe Asp Glu Cys Glu Ala Ala Val Met Leu Val Ser Leu Gly Ser 
        595                 600                 605             


Ser Arg Ser Gly Xaa Pro Ser Phe Ser Pro Val Ser Xaa Gln Ser Pro 
    610                 615                 620                 


Phe Ser Pro Ala Pro Ser Pro Ser Pro Ser Pro Leu Phe Gly Phe Arg 
625                 630                 635                 640 


Pro Ala Asn Phe Ser Pro Ile Asn Ala Ser Pro Val Ile Gln Arg Xaa 
                645                 650                 655     


Ala Val Arg Ser Arg His Leu Ser Ala Ser Xaa Pro Lys Ala Gly Val 
            660                 665                 670         


Leu Xaa Pro Pro Asp Leu Gly Pro His Pro Pro Pro Pro Ala Pro Arg 
        675                 680                 685             


Glu Arg His Ser Ser Gly Ile Leu Pro Xaa Phe Gln Xaa Asn Leu Xaa 
    690                 695                 700                 


Phe Xaa Val Pro Ile Ser Pro Gly Arg Arg Lys Xaa Glu Leu Leu Pro 
705                 710                 715                 720 


His Pro Gly Ala Leu Gly Ala Pro Gly Ala Gly Gly Gly Gly Ala Ala 
                725                 730                 735     


Pro Asp Phe Pro Lys Ser Asp Ser Leu Asp Ser Gly Val Asp Ser Val 
            740                 745                 750         


Ser His Xaa Pro Xaa Pro Ser Xaa Pro Ala Gly Phe Arg Ala Val Ser 
        755                 760                 765             


Pro Ala Val Pro Phe Ser Arg Ser Arg Gln Pro Ser Pro Leu Leu Leu 
    770                 775                 780                 


Leu Pro Pro Pro Ala Gly Leu Xaa Ser Asp Pro Gly Pro Ser Val Arg 
785                 790                 795                 800 


Arg Val Pro Ala Val Gln Arg Asp Ser Pro Val Ile Val Arg Asn Pro 
                805                 810                 815     


Asp Val Pro Leu Pro Ser Lys Phe Pro Gly Glu Val Gly Xaa Ala Gly 
            820                 825                 830         


Glu Val Arg Ala Gly Gly Pro Gly Arg Gly Cys Arg Glu Xaa Pro Val 
        835                 840                 845             


Pro Pro Gly Val Ala Ser Gly Lys Pro Gly Leu Pro Pro Pro Leu Pro 
    850                 855                 860                 


Ala Pro Val Pro Ile Xaa Val Pro Pro Ala Ala Pro Xaa Ala Val Ala 
865                 870                 875                 880 


Gln Pro Met Pro Ala Phe Gly Leu Ala Ser Ser Pro Phe Gln Pro Val 
                885                 890                 895     


Ala Phe His Pro Ser Pro Ala Ala Leu Leu Pro Val Leu Val Pro Ser 
            900                 905                 910         


Ser Tyr Xaa Ser His Pro Ala Pro Lys Lys Glu Val Ile Met Gly Arg 
        915                 920                 925             


Pro Gly Xaa Val Trp Xaa Asn Val Glu Pro Arg Ser Val Ala Val Phe 
    930                 935                 940                 


Pro Trp His Ser Leu Val Pro Phe Leu Ala Pro Ser Gln Pro Asp Pro 
945                 950                 955                 960 


Ser Val Gln Pro Ser Glu Ala Gln Gln Pro Ala Ser His Pro Val Ala 
                965                 970                 975     


Ser Asn Gln Ser Lys Glu Pro Ala Glu Ser Ala Ala Val Ala His Glu 
            980                 985                 990         


Arg Pro Pro Gly Gly Xaa Gly Ser  Ala Asp Pro Glu Arg  Pro Pro Gly 
        995                 1000                 1005             


Ala Xaa  Cys Pro Glu Ser Pro  Gly Pro Gly Pro Pro  His Pro Leu 
    1010                 1015                 1020             


Gly Val  Val Glu Ser Gly Lys  Gly Pro Pro Pro Xaa  Xaa Glu Glu 
    1025                 1030                 1035             


Glu Ala  Ser Gly Pro Pro Gly  Glu Pro Arg Leu Asp  Ser Glu Xaa 
    1040                 1045                 1050             


Glu Ser  Asp His Asp Asp Ala  Phe Leu Ser Ile Met  Ser Pro Glu 
    1055                 1060                 1065             


Ile Gln  Leu Pro Leu Pro Pro  Gly Lys Arg Arg Xaa  Gln Ser Leu 
    1070                 1075                 1080             


Ser Ala  Leu Pro Lys Glu Arg  Asp Ser Ser Ser Glu  Lys Asp Gly 
    1085                 1090                 1095             


Arg Ser  Pro Asn Lys Arg Glu  Lys Asp His Ile Arg  Arg Pro Met 
    1100                 1105                 1110             


Asn Ala  Phe Met Ile Phe Ser  Lys Arg His Arg Ala  Leu Val His 
    1115                 1120                 1125             


Gln Arg  His Pro Asn Gln Asp  Asn Arg Xaa Val Ser  Lys Ile Leu 
    1130                 1135                 1140             


Gly Glu  Trp Trp Tyr Ala Leu  Gly Pro Lys Glu Lys  Gln Lys Tyr 
    1145                 1150                 1155             


His Asp  Leu Ala Phe Gln Val  Lys Glu Ala His Phe  Lys Ala His 
    1160                 1165                 1170             


Pro Asp  Trp Lys Trp Cys Asn  Lys Asp Arg Lys Lys  Ser Ser Ser 
    1175                 1180                 1185             


Glu Ala  Lys Pro Xaa Ser Leu  Gly Leu Ala Gly Gly  His Lys Glu 
    1190                 1195                 1200             


Xaa Arg  Glu Arg Ser Met Ser  Glu Xaa Gly Xaa Ala  Ala Ala Pro 
    1205                 1210                 1215             


Gly Val  Ser Ser Glu Leu Leu  Ser Val Ala Ala Gln  Xaa Leu Leu 
    1220                 1225                 1230             


Ser Ser  Asp Xaa Lys Ala Pro  Gly Ser Ser Ser Cys  Gly Ala Glu 
    1235                 1240                 1245             


Arg Leu  His Xaa Val Gly Gly  Pro Gly Ser Ala Arg  Pro Arg Ala 
    1250                 1255                 1260             


Phe Ser  His Ser Gly Val His  Ser Leu Asp Gly Gly  Glu Val Asp 
    1265                 1270                 1275             


Ser Gln  Ala Leu Gln Glu Leu  Xaa Gln Met Val Ser  Gly Pro Ala 
    1280                 1285                 1290             


Ser Tyr  Ser Gly Pro Lys Pro  Ser Xaa Gln Tyr Gly  Ala Pro Gly 
    1295                 1300                 1305             


Pro Phe  Ala Ala Pro Gly Glu  Gly Gly Ala Leu Ala  Ala Xaa Gly 
    1310                 1315                 1320             


Arg Pro  Pro Leu Leu Pro Xaa  Arg Ala Ser Arg Ser  Gln Arg Ala 
    1325                 1330                 1335             


Ala Ser  Glu Asp Met Xaa Ser  Asp Glu Glu Arg Met  Val Ile Cys 
    1340                 1345                 1350             


Glu Glu  Glu Gly Asp Asp Asp  Val Ile Ala Asp Asp  Gly Phe Gly 
    1355                 1360                 1365             


Xaa Xaa  Asp Ile Asp Leu Lys  Cys Lys Glu Arg Val  Xaa Asp Ser 
    1370                 1375                 1380             


Glu Ser  Gly Asp Ser Ser Gly  Glu Asp Pro Glu Gly  Asn Lys Gly 
    1385                 1390                 1395             


Phe Gly  Arg Lys Val Phe Ser  Pro Val Ile Arg Ser  Ser Phe Xaa 
    1400                 1405                 1410             


His Cys  Arg Pro Pro Leu Asp  Pro Glu Pro Pro Gly  Pro Pro Asp 
    1415                 1420                 1425             


Pro Pro  Val Ala Phe Gly Lys  Gly Tyr Gly Ser Ala  Pro Ser Ser 
    1430                 1435                 1440             


Ser Ala  Ser Ser Pro Ala Ser  Ser Ser Ala Ser Ala  Ala Xaa Ser 
    1445                 1450                 1455             


Phe Ser  Leu Gly Ser Gly Xaa  Phe Lys Ala Gln Glu  Ser Gly Gln 
    1460                 1465                 1470             


Gly Ser  Xaa Ala Gly Pro Leu  Arg Pro Pro Pro Pro  Gly Ala Gly 
    1475                 1480                 1485             


Gly Pro  Ala Xaa Pro Ser Lys  Ala Xaa Arg Phe Leu  Pro Met Asp 
    1490                 1495                 1500             


Pro Ala  Xaa Phe Arg Arg Lys  Arg Pro Glu Ser Val  Gly Gly Leu 
    1505                 1510                 1515             


Glu Pro  Pro Gly Pro Ser Val  Ile Ala Ala Pro Pro  Ser Gly Gly 
    1520                 1525                 1530             


Gly Asn  Ile Leu Gln Xaa Leu  Val Leu Pro Pro Asn  Lys Glu Glu 
    1535                 1540                 1545             


Gln Glu  Gly Gly Gly Ala Arg  Val Pro Ser Ala Pro  Ala Pro Ser 
    1550                 1555                 1560             


Leu Ala  Tyr Gly Ala Pro Ala  Ala Pro Leu Ser Arg  Pro Ala Ala 
    1565                 1570                 1575             


Xaa Met  Val Xaa Asn Val Val  Arg Pro Val Ser Ser  Xaa Pro Val 
    1580                 1585                 1590             


Pro Ile  Ala Ser Lys Pro Phe  Pro Xaa Ser Gly Arg  Ala Glu Ala 
    1595                 1600                 1605             


Ser Pro  Asn Asp Xaa Ala Gly  Ala Arg Xaa Glu Met  Gly Xaa Gly 
    1610                 1615                 1620             


Ser Arg  Val Pro Gly Gly Ser  Pro Leu Gly Val Ser  Leu Val Tyr 
    1625                 1630                 1635             


Ser Asp  Lys Lys Ser Ala Ala  Ala Xaa Ser Pro Ala  Pro His Leu 
    1640                 1645                 1650             


Val Ala  Gly Pro Leu Leu Gly  Xaa Val Gly Lys Ala  Pro Ala Xaa 
    1655                 1660                 1665             


Val Xaa  Asn Leu Leu Val Gly  Xaa Pro Gly Tyr Gly  Ala Pro Ala 
    1670                 1675                 1680             


Pro Pro  Ala Val Gln Phe Ile  Ala Gln Gly Ala Pro  Gly Gly Gly 
    1685                 1690                 1695             


Xaa Xaa  Ala Gly Ser Gly Ala  Gly Ala Gly Ser Gly  Pro Asn Gly 
    1700                 1705                 1710             


Pro Val  Pro Leu Gly Ile Leu  Gln Pro Gly Ala Leu  Gly Lys Ala 
    1715                 1720                 1725             


Gly Gly  Ile Xaa Gln Val Gln  Tyr Ile Leu Pro Xaa  Leu Pro Gln 
    1730                 1735                 1740             


Gln Leu  Gln Val Ala Pro Ala  Pro Ala Pro Ala Pro  Gly Xaa Lys 
    1745                 1750                 1755             


Ala Ala  Ala Pro Ser Gly Pro  Ala Pro Xaa Xaa Ser  Ile Arg Phe 
    1760                 1765                 1770             


Xaa Leu  Pro Pro Gly Xaa Ser  Xaa Asn Gly Lys Val  Leu Ala Ala 
    1775                 1780                 1785             


Xaa Ala  Pro Xaa Pro Gly Ile  Pro Ile Leu Gln Ser  Val Pro Ser 
    1790                 1795                 1800             


Ala Pro  Pro Pro Lys Ala Gln  Ser Val Ser Pro Val  Gln Ala Pro 
    1805                 1810                 1815             


Pro Pro  Gly Gly Ser Ala Gln  Leu Leu Pro Gly Lys  Val Leu Val 
    1820                 1825                 1830             


Pro Leu  Ala Ala Pro Ser Met  Ser Val Arg Gly Gly  Gly Ala Gly 
    1835                 1840                 1845             


Gln Pro  Leu Pro Leu Val Ser  Pro Pro Phe Ser Val  Pro Val Gln 
    1850                 1855                 1860             


Asn Gly  Ala Gln Pro Pro Ser  Lys Ile Ile Gln Leu  Xaa Pro Val 
    1865                 1870                 1875             


Pro Val  Ser Xaa Pro Ser Gly  Leu Val Pro Pro Leu  Ser Pro Ala 
    1880                 1885                 1890             


Xaa Leu  Pro Gly Pro Xaa Ser  Gln Pro Gln Lys Val  Leu Leu Pro 
    1895                 1900                 1905             


Ser Ser  Xaa Arg Ile Xaa Tyr  Val Gln Ser Ala Gly  Gly His Ala 
    1910                 1915                 1920             


Leu Pro  Leu Gly Xaa Ser Pro  Ala Ser Ser Gln Ala  Gly Xaa Val 
    1925                 1930                 1935             


Xaa Ser  Tyr Gly Pro Xaa Ser  Ser Val Ala Leu Gly  Phe Xaa Ser 
    1940                 1945                 1950             


Leu Gly  Pro Ser Gly Pro Ala  Phe Val Gln Pro Leu  Leu Ser Gly 
    1955                 1960                 1965             


Gln Ala  Pro Leu Leu Ala Pro  Gly Gln Val Gly Val  Ser Pro Val 
    1970                 1975                 1980             


Pro Ser  Pro Gln Leu Pro Pro  Ala Cys Ala Ala Pro  Gly Gly Pro 
    1985                 1990                 1995             


Val Ile  Xaa Ala Phe Tyr Ser  Gly Ser Pro Ala Pro  Xaa Ser Ser 
    2000                 2005                 2010             


Ala Pro  Leu Ala Gln Pro Ser  Gln Ala Pro Pro Ser  Leu Val Tyr 
    2015                 2020                 2025             


Xaa Val  Ala Xaa Ser Xaa Xaa  Pro Pro Ala Ala Xaa  Ile Leu Pro 
    2030                 2035                 2040             


Lys Gly  Pro Pro Ala Pro Ala  Xaa Ala Xaa Pro Ala  Pro Xaa Ser 
    2045                 2050                 2055             


Pro Phe  Pro Ser Ala Xaa Gly  Ser Met Xaa Tyr Ser  Leu Val Ala 
    2060                 2065                 2070             


Pro Lys  Ala Gln Arg Pro Ser  Pro Lys Ala Pro Gln  Lys Val Lys 
    2075                 2080                 2085             


Ala Ala  Ile Ala Ser Ile Pro  Val Gly Ser Phe Glu  Ala Gly Ala 
    2090                 2095                 2100             


Ser Gly  Arg Pro Gly Pro Ala  Pro Arg Gln Pro Leu  Glu Pro Gly 
    2105                 2110                 2115             


Pro Val  Arg Glu Pro Xaa Ala  Pro Glu Ser Glu Leu  Glu Gly Gln 
    2120                 2125                 2130             


Pro Xaa  Pro Pro Ala Pro Pro  Pro Leu Pro Glu Xaa  Trp Xaa Pro 
    2135                 2140                 2145             


Xaa Ala  Arg Ser Ser Pro Pro  Leu Pro Pro Pro Ala  Glu Glu Arg 
    2150                 2155                 2160             


Xaa Ser  Ala Lys Gly Pro Glu  Xaa Met Ala Ser Lys  Phe Pro Ser 
    2165                 2170                 2175             


Ser Ser  Ser Asp Trp Arg Val  Pro Gly Gln Gly Leu  Glu Asn Arg 
    2180                 2185                 2190             


Gly Glu  Pro Pro Xaa Pro Pro  Ser Pro Ala Pro Ala  Pro Ala Val 
    2195                 2200                 2205             


Ala Pro  Gly Gly Ser Ser Glu  Ser Ser Ser Gly Arg  Ala Ala Gly 
    2210                 2215                 2220             


Asp Xaa  Pro Glu Arg Lys Glu  Ala Ala Gly Xaa Gly  Lys Lys Val 
    2225                 2230                 2235             


Lys Val  Arg Pro Pro Pro Leu  Lys Lys Xaa Phe Asp  Ser Val Asp 
    2240                 2245                 2250             


Lys Val  Leu Ser Glu Val Asp  Phe Glu Glu Arg Phe  Ala Glu Leu 
    2255                 2260                 2265             


Pro Glu  Phe Arg Pro Glu Glu  Val Leu Pro Ser Pro  Xaa Leu Gln 
    2270                 2275                 2280             


Ser Leu  Ala Xaa Ser Pro Arg  Ala Ile Leu Gly Ser  Tyr Arg Lys 
    2285                 2290                 2295             


Lys Arg  Lys Asn Ser Xaa Asp  Leu Asp Ser Ala Pro  Glu Asp Pro 
    2300                 2305                 2310             


Xaa Ser  Pro Lys Arg Lys Met  Arg Arg Arg Ser Ser  Cys Ser Ser 
    2315                 2320                 2325             


Glu Pro  Asn Xaa Pro Lys Ser  Ala Lys Cys Glu Gly  Asp Ile Phe 
    2330                 2335                 2340             


Xaa Phe  Asp Arg Xaa Gly Xaa  Glu Ala Glu Asp Val  Leu Gly Glu 
    2345                 2350                 2355             


Leu Glu  Tyr Asp Lys Val Pro  Tyr Ser Ser Leu Arg  Arg Xaa Leu 
    2360                 2365                 2370             


Asp Gln  Arg Arg Ala Leu Val  Met Gln Leu Phe Gln  Asp His Gly 
    2375                 2380                 2385             


Phe Phe  Pro Ser Ala Gln Ala  Xaa Ala Ala Phe Gln  Ala Arg Tyr 
    2390                 2395                 2400             


Ala Asp  Ile Phe Pro Ser Lys  Val Cys Leu Gln Leu  Lys Ile Arg 
    2405                 2410                 2415             


Glu Val  Arg Gln Lys Ile Met  Gln Ala Ala Xaa Pro  Xaa Glu Gln 
    2420                 2425                 2430             


Pro Pro  Gly Ala Glu Ala Pro  Leu Pro Val Pro Pro  Pro Xaa Gly 
    2435                 2440                 2445             


Xaa Ala  Ala Ala Pro Ala Pro  Xaa Pro Ser Pro Ala  Gly Gly Pro 
    2450                 2455                 2460             


Asp Pro  Xaa Ser Pro Ser Ser  Asp Ser Gly Xaa Ala  Gln Ala Ala 
    2465                 2470                 2475             


Pro Pro  Leu Pro Pro Pro Pro  Glu Ser Gly Pro Gly  Gln Pro Gly 
    2480                 2485                 2490             


Trp Glu  Gly Ala Pro Gln Pro  Ser Pro Pro Pro Pro  Gly Pro Ser 
    2495                 2500                 2505             


Xaa Ala  Ala Xaa Gly Arg 
    2510                 


<210> 6234
<211> 1606
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1102)..(1102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1120)..(1120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1123)..(1123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1131)..(1131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1142)..(1142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1226)..(1226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1238)..(1238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1240)..(1240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1255)..(1255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1262)..(1262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1316)..(1316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1325)..(1325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1339)..(1339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1379)..(1379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1396)..(1396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1406)..(1406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1424)..(1424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1436)..(1436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1440)..(1440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1442)..(1442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1464)..(1464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1488)..(1488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1521)..(1521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1523)..(1523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1539)..(1539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1541)..(1541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1548)..(1548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1558)..(1558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1566)..(1566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1601)..(1601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1604)..(1604)
<223> Selenocysteine

<400> 6234
Met Tyr Ser Ala His Arg Pro Leu Met Pro Ala Ser Ser Ala Ala Ser 
1               5                   10                  15      


Arg Gly Leu Gly Met Phe Val Trp Xaa Asn Val Glu Pro Arg Ser Val 
            20                  25                  30          


Ala Val Phe Pro Trp His Ser Leu Val Pro Phe Leu Ala Pro Ser Gln 
        35                  40                  45              


Pro Asp Pro Ser Val Gln Pro Ser Glu Ala Gln Gln Pro Ala Ser His 
    50                  55                  60                  


Pro Val Ala Ser Asn Gln Ser Lys Glu Pro Ala Glu Ser Ala Ala Val 
65                  70                  75                  80  


Ala His Glu Arg Pro Pro Gly Gly Xaa Gly Ser Ala Asp Pro Glu Arg 
                85                  90                  95      


Pro Pro Gly Ala Xaa Cys Pro Glu Ser Pro Gly Pro Gly Pro Pro His 
            100                 105                 110         


Pro Leu Gly Val Val Glu Ser Gly Lys Gly Pro Pro Pro Xaa Xaa Glu 
        115                 120                 125             


Glu Glu Ala Ser Gly Pro Pro Gly Glu Pro Arg Leu Asp Ser Glu Xaa 
    130                 135                 140                 


Glu Ser Asp His Asp Asp Ala Phe Leu Ser Ile Met Ser Pro Glu Ile 
145                 150                 155                 160 


Gln Leu Pro Leu Pro Pro Gly Lys Arg Arg Xaa Gln Ser Leu Ser Ala 
                165                 170                 175     


Leu Pro Lys Glu Arg Asp Ser Ser Ser Glu Lys Asp Gly Arg Ser Pro 
            180                 185                 190         


Asn Lys Arg Glu Lys Asp His Ile Arg Arg Pro Met Asn Ala Phe Met 
        195                 200                 205             


Ile Phe Ser Lys Arg His Arg Ala Leu Val His Gln Arg His Pro Asn 
    210                 215                 220                 


Gln Asp Asn Arg Xaa Val Ser Lys Ile Leu Gly Glu Trp Trp Tyr Ala 
225                 230                 235                 240 


Leu Gly Pro Lys Glu Lys Gln Lys Tyr His Asp Leu Ala Phe Gln Val 
                245                 250                 255     


Lys Glu Ala His Phe Lys Ala His Pro Asp Trp Lys Trp Cys Asn Lys 
            260                 265                 270         


Asp Arg Lys Lys Ser Ser Ser Glu Ala Lys Pro Xaa Ser Leu Gly Leu 
        275                 280                 285             


Ala Gly Gly His Lys Glu Xaa Arg Glu Arg Ser Met Ser Glu Xaa Gly 
    290                 295                 300                 


Xaa Ala Ala Ala Pro Gly Val Ser Ser Glu Leu Leu Ser Val Ala Ala 
305                 310                 315                 320 


Gln Xaa Leu Leu Ser Ser Asp Xaa Lys Ala Pro Gly Ser Ser Ser Cys 
                325                 330                 335     


Gly Ala Glu Arg Leu His Xaa Val Gly Gly Pro Gly Ser Ala Arg Pro 
            340                 345                 350         


Arg Ala Phe Ser His Ser Gly Val His Ser Leu Asp Gly Gly Glu Val 
        355                 360                 365             


Asp Ser Gln Ala Leu Gln Glu Leu Xaa Gln Met Val Ser Gly Pro Ala 
    370                 375                 380                 


Ser Tyr Ser Gly Pro Lys Pro Ser Xaa Gln Tyr Gly Ala Pro Gly Pro 
385                 390                 395                 400 


Phe Ala Ala Pro Gly Glu Gly Gly Ala Leu Ala Ala Xaa Gly Arg Pro 
                405                 410                 415     


Pro Leu Leu Pro Xaa Arg Ala Ser Arg Ser Gln Arg Ala Ala Ser Glu 
            420                 425                 430         


Asp Met Xaa Ser Asp Glu Glu Arg Met Val Ile Cys Glu Glu Glu Gly 
        435                 440                 445             


Asp Asp Asp Val Ile Ala Asp Asp Gly Phe Gly Xaa Xaa Asp Ile Asp 
    450                 455                 460                 


Leu Lys Cys Lys Glu Arg Val Xaa Asp Ser Glu Ser Gly Asp Ser Ser 
465                 470                 475                 480 


Gly Glu Asp Pro Glu Gly Asn Lys Gly Phe Gly Arg Lys Val Phe Ser 
                485                 490                 495     


Pro Val Ile Arg Ser Ser Phe Xaa His Cys Arg Pro Pro Leu Asp Pro 
            500                 505                 510         


Glu Pro Pro Gly Pro Pro Asp Pro Pro Val Ala Phe Gly Lys Gly Tyr 
        515                 520                 525             


Gly Ser Ala Pro Ser Ser Ser Ala Ser Ser Pro Ala Ser Ser Ser Ala 
    530                 535                 540                 


Ser Ala Ala Xaa Ser Phe Ser Leu Gly Ser Gly Xaa Phe Lys Ala Gln 
545                 550                 555                 560 


Glu Ser Gly Gln Gly Ser Xaa Ala Gly Pro Leu Arg Pro Pro Pro Pro 
                565                 570                 575     


Gly Ala Gly Gly Pro Ala Xaa Pro Ser Lys Ala Xaa Arg Phe Leu Pro 
            580                 585                 590         


Met Asp Pro Ala Xaa Phe Arg Arg Lys Arg Pro Glu Ser Val Gly Gly 
        595                 600                 605             


Leu Glu Pro Pro Gly Pro Ser Val Ile Ala Ala Pro Pro Ser Gly Gly 
    610                 615                 620                 


Gly Asn Ile Leu Gln Xaa Leu Val Leu Pro Pro Asn Lys Glu Glu Gln 
625                 630                 635                 640 


Glu Gly Gly Gly Ala Arg Val Pro Ser Ala Pro Ala Pro Ser Leu Ala 
                645                 650                 655     


Tyr Gly Ala Pro Ala Ala Pro Leu Ser Arg Pro Ala Ala Xaa Met Val 
            660                 665                 670         


Xaa Asn Val Val Arg Pro Val Ser Ser Xaa Pro Val Pro Ile Ala Ser 
        675                 680                 685             


Lys Pro Phe Pro Xaa Ser Gly Arg Ala Glu Ala Ser Pro Asn Asp Xaa 
    690                 695                 700                 


Ala Gly Ala Arg Xaa Glu Met Gly Xaa Gly Ser Arg Val Pro Gly Gly 
705                 710                 715                 720 


Ser Pro Leu Gly Val Ser Leu Val Tyr Ser Asp Lys Lys Ser Ala Ala 
                725                 730                 735     


Ala Xaa Ser Pro Ala Pro His Leu Val Ala Gly Pro Leu Leu Gly Xaa 
            740                 745                 750         


Val Gly Lys Ala Pro Ala Xaa Val Xaa Asn Leu Leu Val Gly Xaa Pro 
        755                 760                 765             


Gly Tyr Gly Ala Pro Ala Pro Pro Ala Val Gln Phe Ile Ala Gln Gly 
    770                 775                 780                 


Ala Pro Gly Gly Gly Xaa Xaa Ala Gly Ser Gly Ala Gly Ala Gly Ser 
785                 790                 795                 800 


Gly Pro Asn Gly Pro Val Pro Leu Gly Ile Leu Gln Pro Gly Ala Leu 
                805                 810                 815     


Gly Lys Ala Gly Gly Ile Xaa Gln Val Gln Tyr Ile Leu Pro Xaa Leu 
            820                 825                 830         


Pro Gln Gln Leu Gln Val Ala Pro Ala Pro Ala Pro Ala Pro Gly Xaa 
        835                 840                 845             


Lys Ala Ala Ala Pro Ser Gly Pro Ala Pro Xaa Xaa Ser Ile Arg Phe 
    850                 855                 860                 


Xaa Leu Pro Pro Gly Xaa Ser Xaa Asn Gly Lys Val Leu Ala Ala Xaa 
865                 870                 875                 880 


Ala Pro Xaa Pro Gly Ile Pro Ile Leu Gln Ser Val Pro Ser Ala Pro 
                885                 890                 895     


Pro Pro Lys Ala Gln Ser Val Ser Pro Val Gln Ala Pro Pro Pro Gly 
            900                 905                 910         


Gly Ser Ala Gln Leu Leu Pro Gly Lys Val Leu Val Pro Leu Ala Ala 
        915                 920                 925             


Pro Ser Met Ser Val Arg Gly Gly Gly Ala Gly Gln Pro Leu Pro Leu 
    930                 935                 940                 


Val Ser Pro Pro Phe Ser Val Pro Val Gln Asn Gly Ala Gln Pro Pro 
945                 950                 955                 960 


Ser Lys Ile Ile Gln Leu Xaa Pro Val Pro Val Ser Xaa Pro Ser Gly 
                965                 970                 975     


Leu Val Pro Pro Leu Ser Pro Ala Xaa Leu Pro Gly Pro Xaa Ser Gln 
            980                 985                 990         


Pro Gln Lys Val Leu Leu Pro Ser  Ser Xaa Arg Ile Xaa  Tyr Val Gln 
        995                 1000                 1005             


Ser Ala  Gly Gly His Ala Leu  Pro Leu Gly Xaa Ser  Pro Ala Ser 
    1010                 1015                 1020             


Ser Gln  Ala Gly Xaa Val Xaa  Ser Tyr Gly Pro Xaa  Ser Ser Val 
    1025                 1030                 1035             


Ala Leu  Gly Phe Xaa Ser Leu  Gly Pro Ser Gly Pro  Ala Phe Val 
    1040                 1045                 1050             


Gln Pro  Leu Leu Ser Gly Gln  Ala Pro Leu Leu Ala  Pro Gly Gln 
    1055                 1060                 1065             


Val Gly  Val Ser Pro Val Pro  Ser Pro Gln Leu Pro  Pro Ala Cys 
    1070                 1075                 1080             


Ala Ala  Pro Gly Gly Pro Val  Ile Xaa Ala Phe Tyr  Ser Gly Ser 
    1085                 1090                 1095             


Pro Ala  Pro Xaa Ser Ser Ala  Pro Leu Ala Gln Pro  Ser Gln Ala 
    1100                 1105                 1110             


Pro Pro  Ser Leu Val Tyr Xaa  Val Ala Xaa Ser Xaa  Xaa Pro Pro 
    1115                 1120                 1125             


Ala Ala  Xaa Ile Leu Pro Lys  Gly Pro Pro Ala Pro  Ala Xaa Ala 
    1130                 1135                 1140             


Xaa Pro  Ala Pro Xaa Ser Pro  Phe Pro Ser Ala Xaa  Gly Ser Met 
    1145                 1150                 1155             


Xaa Tyr  Ser Leu Val Ala Pro  Lys Ala Gln Arg Pro  Ser Pro Lys 
    1160                 1165                 1170             


Ala Pro  Gln Lys Val Lys Ala  Ala Ile Ala Ser Ile  Pro Val Gly 
    1175                 1180                 1185             


Ser Phe  Glu Ala Gly Ala Ser  Gly Arg Pro Gly Pro  Ala Pro Arg 
    1190                 1195                 1200             


Gln Pro  Leu Glu Pro Gly Pro  Val Arg Glu Pro Xaa  Ala Pro Glu 
    1205                 1210                 1215             


Ser Glu  Leu Glu Gly Gln Pro  Xaa Pro Pro Ala Pro  Pro Pro Leu 
    1220                 1225                 1230             


Pro Glu  Xaa Trp Xaa Pro Xaa  Ala Arg Ser Ser Pro  Pro Leu Pro 
    1235                 1240                 1245             


Pro Pro  Ala Glu Glu Arg Xaa  Ser Ala Lys Gly Pro  Glu Xaa Met 
    1250                 1255                 1260             


Ala Ser  Lys Phe Pro Ser Ser  Ser Ser Asp Trp Arg  Val Pro Gly 
    1265                 1270                 1275             


Gln Gly  Leu Glu Asn Arg Gly  Glu Pro Pro Xaa Pro  Pro Ser Pro 
    1280                 1285                 1290             


Ala Pro  Ala Pro Ala Val Ala  Pro Gly Gly Ser Ser  Glu Ser Ser 
    1295                 1300                 1305             


Ser Gly  Arg Ala Ala Gly Asp  Xaa Pro Glu Arg Lys  Glu Ala Ala 
    1310                 1315                 1320             


Gly Xaa  Gly Lys Lys Val Lys  Val Arg Pro Pro Pro  Leu Lys Lys 
    1325                 1330                 1335             


Xaa Phe  Asp Ser Val Asp Asn  Arg Val Leu Ser Glu  Val Asp Phe 
    1340                 1345                 1350             


Glu Glu  Arg Phe Ala Glu Leu  Pro Glu Phe Arg Pro  Glu Glu Val 
    1355                 1360                 1365             


Leu Pro  Ser Pro Xaa Leu Gln  Ser Leu Ala Xaa Ser  Pro Arg Ala 
    1370                 1375                 1380             


Ile Leu  Gly Ser Tyr Arg Lys  Lys Arg Lys Asn Ser  Xaa Asp Leu 
    1385                 1390                 1395             


Asp Ser  Ala Pro Glu Asp Pro  Xaa Ser Pro Lys Arg  Lys Met Arg 
    1400                 1405                 1410             


Arg Arg  Ser Ser Cys Ser Ser  Glu Pro Asn Xaa Pro  Lys Ser Ala 
    1415                 1420                 1425             


Lys Cys  Glu Gly Asp Ile Phe  Xaa Phe Asp Arg Xaa  Gly Xaa Glu 
    1430                 1435                 1440             


Ala Glu  Asp Val Leu Gly Glu  Leu Glu Tyr Asp Lys  Val Pro Tyr 
    1445                 1450                 1455             


Ser Ser  Leu Arg Arg Xaa Leu  Asp Gln Arg Arg Ala  Leu Val Met 
    1460                 1465                 1470             


Gln Leu  Phe Gln Asp His Gly  Phe Phe Pro Ser Ala  Gln Ala Xaa 
    1475                 1480                 1485             


Ala Ala  Phe Gln Ala Arg Tyr  Ala Asp Ile Phe Pro  Ser Lys Val 
    1490                 1495                 1500             


Cys Leu  Gln Leu Lys Ile Arg  Glu Val Arg Gln Lys  Ile Met Gln 
    1505                 1510                 1515             


Ala Ala  Xaa Pro Xaa Glu Gln  Pro Pro Gly Ala Glu  Ala Pro Leu 
    1520                 1525                 1530             


Pro Val  Pro Pro Pro Xaa Gly  Xaa Ala Ala Ala Pro  Ala Pro Xaa 
    1535                 1540                 1545             


Pro Ser  Pro Ala Gly Gly Pro  Asp Pro Xaa Ser Pro  Ser Ser Asp 
    1550                 1555                 1560             


Ser Gly  Xaa Ala Gln Ala Ala  Pro Pro Leu Pro Pro  Pro Pro Glu 
    1565                 1570                 1575             


Ser Gly  Pro Gly Gln Pro Gly  Trp Glu Gly Ala Pro  Gln Pro Ser 
    1580                 1585                 1590             


Pro Pro  Pro Pro Gly Pro Ser  Xaa Ala Ala Xaa Gly  Arg 
    1595                 1600                 1605     


<210> 6235
<211> 1608
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1093)..(1093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1103)..(1103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1145)..(1145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1161)..(1161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1238)..(1238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1240)..(1240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1291)..(1291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1327)..(1327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1375)..(1375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1398)..(1398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1426)..(1426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1438)..(1438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1442)..(1442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1444)..(1444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1466)..(1466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1490)..(1490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1523)..(1523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1525)..(1525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1541)..(1541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1543)..(1543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1550)..(1550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1560)..(1560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1603)..(1603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<400> 6235
Met Tyr Ser Ala His Arg Pro Leu Met Pro Ala Ser Ser Ala Ala Ser 
1               5                   10                  15      


Arg Gly Leu Gly Met Phe Val Trp Xaa Asn Val Glu Pro Arg Ser Val 
            20                  25                  30          


Ala Val Phe Pro Trp His Ser Leu Val Pro Phe Leu Ala Pro Ser Gln 
        35                  40                  45              


Pro Asp Pro Ser Val Gln Pro Ser Glu Ala Gln Gln Pro Ala Ser His 
    50                  55                  60                  


Pro Val Ala Ser Asn Gln Ser Lys Glu Pro Ala Glu Ser Ala Ala Val 
65                  70                  75                  80  


Ala His Glu Arg Pro Pro Gly Gly Xaa Gly Ser Ala Asp Pro Glu Arg 
                85                  90                  95      


Pro Pro Gly Ala Xaa Cys Pro Glu Ser Pro Gly Pro Gly Pro Pro His 
            100                 105                 110         


Pro Leu Gly Val Val Glu Ser Gly Lys Gly Pro Pro Pro Xaa Xaa Glu 
        115                 120                 125             


Glu Glu Ala Ser Gly Pro Pro Gly Glu Pro Arg Leu Asp Ser Glu Xaa 
    130                 135                 140                 


Glu Ser Asp His Asp Asp Ala Phe Leu Ser Ile Met Ser Pro Glu Ile 
145                 150                 155                 160 


Gln Leu Pro Leu Pro Pro Gly Lys Arg Arg Xaa Gln Ser Leu Ser Ala 
                165                 170                 175     


Leu Pro Lys Glu Arg Asp Ser Ser Ser Glu Lys Asp Gly Arg Ser Pro 
            180                 185                 190         


Asn Lys Arg Glu Lys Asp His Ile Arg Arg Pro Met Asn Ala Phe Met 
        195                 200                 205             


Ile Phe Ser Lys Arg His Arg Ala Leu Val His Gln Arg His Pro Asn 
    210                 215                 220                 


Gln Asp Asn Arg Xaa Val Ser Lys Ile Leu Gly Glu Trp Trp Tyr Ala 
225                 230                 235                 240 


Leu Gly Pro Lys Glu Lys Gln Lys Tyr His Asp Leu Ala Phe Gln Val 
                245                 250                 255     


Lys Glu Ala His Phe Lys Ala His Pro Asp Trp Lys Trp Cys Asn Lys 
            260                 265                 270         


Asp Arg Lys Lys Ser Ser Ser Glu Ala Lys Pro Xaa Ser Leu Gly Leu 
        275                 280                 285             


Ala Gly Gly His Lys Glu Xaa Arg Glu Arg Ser Met Ser Glu Xaa Gly 
    290                 295                 300                 


Xaa Ala Ala Ala Pro Gly Val Ser Ser Glu Leu Leu Ser Val Ala Ala 
305                 310                 315                 320 


Gln Xaa Leu Leu Ser Ser Asp Xaa Lys Ala Pro Gly Ser Ser Ser Cys 
                325                 330                 335     


Gly Ala Glu Arg Leu His Xaa Val Gly Gly Pro Gly Ser Ala Arg Pro 
            340                 345                 350         


Arg Ala Phe Ser His Ser Gly Val His Ser Leu Asp Gly Gly Glu Val 
        355                 360                 365             


Asp Ser Gln Ala Leu Gln Glu Leu Xaa Gln Met Val Ser Gly Pro Ala 
    370                 375                 380                 


Ser Tyr Ser Gly Pro Lys Pro Ser Xaa Gln Tyr Gly Ala Pro Gly Pro 
385                 390                 395                 400 


Phe Ala Ala Pro Gly Glu Gly Gly Ala Leu Ala Ala Xaa Gly Arg Pro 
                405                 410                 415     


Pro Leu Leu Pro Xaa Arg Ala Ser Arg Ser Gln Arg Ala Ala Ser Glu 
            420                 425                 430         


Asp Met Xaa Ser Asp Glu Glu Arg Met Val Ile Cys Glu Glu Glu Gly 
        435                 440                 445             


Asp Asp Asp Val Ile Ala Asp Asp Gly Phe Gly Xaa Xaa Asp Ile Asp 
    450                 455                 460                 


Leu Lys Cys Lys Glu Arg Val Xaa Asp Ser Glu Ser Gly Asp Ser Ser 
465                 470                 475                 480 


Gly Glu Asp Pro Glu Gly Asn Lys Gly Phe Gly Arg Lys Val Phe Ser 
                485                 490                 495     


Pro Val Ile Arg Ser Ser Phe Xaa His Cys Arg Pro Pro Leu Asp Pro 
            500                 505                 510         


Glu Pro Pro Gly Pro Pro Asp Pro Pro Val Ala Phe Gly Lys Gly Tyr 
        515                 520                 525             


Gly Ser Ala Pro Ser Ser Ser Ala Ser Ser Pro Ala Ser Ser Ser Ala 
    530                 535                 540                 


Ser Ala Ala Xaa Ser Phe Ser Leu Gly Ser Gly Xaa Phe Lys Ala Gln 
545                 550                 555                 560 


Glu Ser Gly Gln Gly Ser Xaa Ala Gly Pro Leu Arg Pro Pro Pro Pro 
                565                 570                 575     


Gly Ala Gly Gly Pro Ala Xaa Pro Ser Lys Ala Xaa Arg Phe Leu Pro 
            580                 585                 590         


Met Asp Pro Ala Xaa Phe Arg Arg Lys Arg Pro Glu Ser Val Gly Gly 
        595                 600                 605             


Leu Glu Pro Pro Gly Pro Ser Val Ile Ala Ala Pro Pro Ser Gly Gly 
    610                 615                 620                 


Gly Asn Ile Leu Gln Xaa Leu Val Leu Pro Pro Asn Lys Glu Glu Gln 
625                 630                 635                 640 


Glu Gly Gly Gly Ala Arg Val Pro Ser Ala Pro Ala Pro Ser Leu Ala 
                645                 650                 655     


Tyr Gly Ala Pro Ala Ala Pro Leu Ser Arg Pro Ala Ala Xaa Met Val 
            660                 665                 670         


Xaa Asn Val Val Arg Pro Val Ser Ser Xaa Pro Val Pro Ile Ala Ser 
        675                 680                 685             


Lys Pro Phe Pro Xaa Ser Gly Arg Ala Glu Ala Ser Pro Asn Asp Xaa 
    690                 695                 700                 


Ala Gly Ala Arg Xaa Glu Met Gly Xaa Gly Ser Arg Val Pro Gly Gly 
705                 710                 715                 720 


Ser Pro Leu Gly Val Ser Leu Val Tyr Ser Asp Lys Lys Ser Ala Ala 
                725                 730                 735     


Ala Xaa Ser Pro Ala Pro His Leu Val Ala Gly Pro Leu Leu Gly Xaa 
            740                 745                 750         


Val Gly Lys Ala Pro Ala Xaa Val Xaa Asn Leu Leu Val Gly Xaa Pro 
        755                 760                 765             


Gly Tyr Gly Ala Pro Ala Pro Pro Ala Val Gln Phe Ile Ala Gln Gly 
    770                 775                 780                 


Ala Pro Gly Gly Gly Xaa Xaa Ala Gly Ser Gly Ala Gly Ala Gly Ser 
785                 790                 795                 800 


Gly Pro Asn Gly Pro Val Pro Leu Gly Ile Leu Gln Pro Gly Ala Leu 
                805                 810                 815     


Gly Lys Ala Gly Gly Ile Xaa Gln Val Gln Tyr Ile Leu Pro Xaa Leu 
            820                 825                 830         


Pro Gln Gln Leu Gln Val Ala Pro Ala Pro Ala Pro Ala Pro Gly Xaa 
        835                 840                 845             


Lys Ala Ala Ala Pro Ser Gly Pro Ala Pro Xaa Xaa Ser Ile Arg Phe 
    850                 855                 860                 


Xaa Leu Pro Pro Gly Xaa Ser Xaa Asn Gly Lys Val Leu Ala Ala Xaa 
865                 870                 875                 880 


Ala Pro Xaa Pro Gly Ile Pro Ile Leu Gln Ser Val Pro Ser Ala Pro 
                885                 890                 895     


Pro Pro Lys Ala Gln Ser Val Ser Pro Val Gln Ala Pro Pro Pro Gly 
            900                 905                 910         


Gly Ser Ala Gln Leu Leu Pro Gly Lys Val Leu Val Pro Leu Ala Ala 
        915                 920                 925             


Pro Ser Met Ser Val Arg Gly Gly Gly Ala Gly Gln Pro Leu Pro Leu 
    930                 935                 940                 


Val Ser Pro Pro Phe Ser Val Pro Val Gln Asn Gly Ala Gln Pro Pro 
945                 950                 955                 960 


Ser Lys Ile Ile Gln Leu Xaa Pro Val Pro Val Ser Xaa Pro Ser Gly 
                965                 970                 975     


Leu Val Pro Pro Leu Ser Pro Ala Xaa Leu Pro Gly Pro Xaa Ser Gln 
            980                 985                 990         


Pro Gln Lys Val Leu Leu Pro Ser  Ser Xaa Arg Ile Xaa  Tyr Val Gln 
        995                 1000                 1005             


Ser Ala  Gly Gly His Ala Leu  Pro Leu Gly Xaa Ser  Pro Ala Ser 
    1010                 1015                 1020             


Ser Gln  Ala Gly Xaa Val Xaa  Ser Tyr Gly Pro Xaa  Ser Ser Val 
    1025                 1030                 1035             


Ala Leu  Gly Phe Xaa Ser Leu  Gly Pro Ser Gly Pro  Ala Phe Val 
    1040                 1045                 1050             


Gln Pro  Leu Leu Ser Ala Gly  Gln Ala Pro Leu Leu  Ala Pro Gly 
    1055                 1060                 1065             


Gln Val  Gly Val Ser Pro Val  Pro Ser Pro Gln Leu  Pro Pro Ala 
    1070                 1075                 1080             


Cys Ala  Ala Pro Gly Gly Pro  Val Ile Xaa Ala Phe  Tyr Ser Gly 
    1085                 1090                 1095             


Ser Pro  Ala Pro Xaa Ser Ser  Ala Pro Leu Ala Gln  Pro Ser Gln 
    1100                 1105                 1110             


Ala Pro  Pro Ser Leu Val Tyr  Xaa Val Ala Xaa Ser  Xaa Xaa Pro 
    1115                 1120                 1125             


Pro Ala  Ala Xaa Ile Leu Pro  Lys Gly Pro Pro Ala  Pro Ala Xaa 
    1130                 1135                 1140             


Ala Xaa  Pro Ala Pro Xaa Ser  Pro Phe Pro Ser Ala  Xaa Ala Gly 
    1145                 1150                 1155             


Ser Met  Xaa Tyr Ser Leu Val  Ala Pro Lys Ala Gln  Arg Pro Ser 
    1160                 1165                 1170             


Pro Lys  Ala Pro Gln Lys Val  Lys Ala Ala Ile Ala  Ser Ile Pro 
    1175                 1180                 1185             


Val Gly  Ser Phe Glu Ala Gly  Ala Ser Gly Arg Pro  Gly Pro Ala 
    1190                 1195                 1200             


Pro Arg  Gln Pro Leu Glu Pro  Gly Pro Val Arg Glu  Pro Xaa Ala 
    1205                 1210                 1215             


Pro Glu  Ser Glu Leu Glu Gly  Gln Pro Xaa Pro Pro  Ala Pro Pro 
    1220                 1225                 1230             


Pro Leu  Pro Glu Xaa Trp Xaa  Pro Xaa Ala Arg Ser  Ser Pro Pro 
    1235                 1240                 1245             


Leu Pro  Pro Pro Ala Glu Glu  Arg Xaa Ser Ala Lys  Gly Pro Glu 
    1250                 1255                 1260             


Xaa Met  Ala Ser Lys Phe Pro  Ser Ser Ser Ser Asp  Trp Arg Val 
    1265                 1270                 1275             


Pro Gly  Gln Gly Leu Glu Asn  Arg Gly Glu Pro Pro  Xaa Pro Pro 
    1280                 1285                 1290             


Ser Pro  Ala Pro Ala Pro Ala  Val Ala Pro Gly Gly  Ser Ser Glu 
    1295                 1300                 1305             


Ser Ser  Ser Gly Arg Ala Ala  Gly Asp Xaa Pro Glu  Arg Lys Glu 
    1310                 1315                 1320             


Ala Ala  Gly Xaa Gly Lys Lys  Val Lys Val Arg Pro  Pro Pro Leu 
    1325                 1330                 1335             


Lys Lys  Xaa Phe Asp Ser Val  Asp Asn Arg Val Leu  Ser Glu Val 
    1340                 1345                 1350             


Asp Phe  Glu Glu Arg Phe Ala  Glu Leu Pro Glu Phe  Arg Pro Glu 
    1355                 1360                 1365             


Glu Val  Leu Pro Ser Pro Xaa  Leu Gln Ser Leu Ala  Xaa Ser Pro 
    1370                 1375                 1380             


Arg Ala  Ile Leu Gly Ser Tyr  Arg Lys Lys Arg Lys  Asn Ser Xaa 
    1385                 1390                 1395             


Asp Leu  Asp Ser Ala Pro Glu  Asp Pro Xaa Ser Pro  Lys Arg Lys 
    1400                 1405                 1410             


Met Arg  Arg Arg Ser Ser Cys  Ser Ser Glu Pro Asn  Xaa Pro Lys 
    1415                 1420                 1425             


Ser Ala  Lys Cys Glu Gly Asp  Ile Phe Xaa Phe Asp  Arg Xaa Gly 
    1430                 1435                 1440             


Xaa Glu  Ala Glu Asp Val Leu  Gly Glu Leu Glu Tyr  Asp Lys Val 
    1445                 1450                 1455             


Pro Tyr  Ser Ser Leu Arg Arg  Xaa Leu Asp Gln Arg  Arg Ala Leu 
    1460                 1465                 1470             


Val Met  Gln Leu Phe Gln Asp  His Gly Phe Phe Pro  Ser Ala Gln 
    1475                 1480                 1485             


Ala Xaa  Ala Ala Phe Gln Ala  Arg Tyr Ala Asp Ile  Phe Pro Ser 
    1490                 1495                 1500             


Lys Val  Cys Leu Gln Leu Lys  Ile Arg Glu Val Arg  Gln Lys Ile 
    1505                 1510                 1515             


Met Gln  Ala Ala Xaa Pro Xaa  Glu Gln Pro Pro Gly  Ala Glu Ala 
    1520                 1525                 1530             


Pro Leu  Pro Val Pro Pro Pro  Xaa Gly Xaa Ala Ala  Ala Pro Ala 
    1535                 1540                 1545             


Pro Xaa  Pro Ser Pro Ala Gly  Gly Pro Asp Pro Xaa  Ser Pro Ser 
    1550                 1555                 1560             


Ser Asp  Ser Gly Xaa Ala Gln  Ala Ala Pro Pro Leu  Pro Pro Pro 
    1565                 1570                 1575             


Pro Glu  Ser Gly Pro Gly Gln  Pro Gly Trp Glu Gly  Ala Pro Gln 
    1580                 1585                 1590             


Pro Ser  Pro Pro Pro Pro Gly  Pro Ser Xaa Ala Ala  Xaa Gly Arg 
    1595                 1600                 1605             


<210> 6236
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<400> 6236
Pro Glu Arg Lys Glu Ala Ala Gly Xaa Gly Lys Lys Val Lys Val Arg 
1               5                   10                  15      


Pro Pro Pro Leu Lys Lys Xaa Phe Asp Ser Val Asp Asn Arg Val Leu 
            20                  25                  30          


Ser Glu Val Asp Phe Glu Glu Arg Phe Ala Glu Leu Pro Glu Phe Arg 
        35                  40                  45              


Pro Glu Glu Val Leu Pro Ser Pro Xaa Leu Gln Ser Leu Ala Xaa Ser 
    50                  55                  60                  


Pro Arg Ala Ile Leu Gly Ser Tyr Arg Lys Lys Arg Lys Asn Ser Xaa 
65                  70                  75                  80  


Asp Leu Asp Ser Ala Pro Glu Asp Pro Xaa Ser Pro Lys Arg Lys Met 
                85                  90                  95      


Arg Arg Arg Ser Ser Cys Ser Ser Glu Pro Asn Xaa Pro Lys Ser Ala 
            100                 105                 110         


Lys Cys Glu Gly Asp Ile Phe Xaa Phe Asp Arg Xaa Ala Leu Pro Cys 
        115                 120                 125             


Cys Leu Cys Pro Ala Gln Val Gln Lys Pro Arg Xaa Cys Leu Gly Ser 
    130                 135                 140                 


<210> 6237
<211> 309
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<400> 6237
Ser Ser Ser Ser Asp Trp Arg Val Pro Gly Gln Gly Leu Glu Asn Arg 
1               5                   10                  15      


Gly Glu Pro Pro Xaa Pro Pro Ser Pro Ala Pro Ala Pro Ala Val Ala 
            20                  25                  30          


Pro Gly Gly Ser Ser Glu Ser Ser Ser Gly Arg Ala Ala Gly Asp Xaa 
        35                  40                  45              


Pro Glu Arg Lys Glu Ala Ala Gly Xaa Gly Lys Lys Val Lys Val Arg 
    50                  55                  60                  


Pro Pro Pro Leu Lys Lys Xaa Phe Asp Ser Val Asp Lys Val Leu Ser 
65                  70                  75                  80  


Glu Val Asp Phe Glu Glu Arg Phe Ala Glu Leu Pro Glu Phe Arg Pro 
                85                  90                  95      


Glu Glu Val Leu Pro Ser Pro Xaa Leu Gln Ser Leu Ala Xaa Ser Pro 
            100                 105                 110         


Arg Ala Ile Leu Gly Ser Tyr Arg Lys Lys Arg Lys Asn Ser Xaa Asp 
        115                 120                 125             


Leu Asp Ser Ala Pro Glu Asp Pro Xaa Ser Pro Lys Arg Lys Met Arg 
    130                 135                 140                 


Arg Arg Ser Ser Cys Ser Ser Glu Pro Asn Xaa Pro Lys Ser Ala Lys 
145                 150                 155                 160 


Cys Glu Gly Asp Ile Phe Xaa Phe Asp Arg Xaa Glu Ala Glu Asp Val 
                165                 170                 175     


Leu Gly Glu Leu Glu Tyr Asp Lys Val Pro Tyr Ser Ser Leu Arg Arg 
            180                 185                 190         


Xaa Leu Asp Gln Arg Arg Ala Leu Val Met Gln Leu Phe Gln Asp His 
        195                 200                 205             


Gly Phe Phe Pro Ser Ala Gln Ala Xaa Ala Ala Phe Gln Ala Arg Tyr 
    210                 215                 220                 


Ala Asp Ile Phe Pro Ser Lys Val Cys Leu Gln Leu Lys Ile Arg Glu 
225                 230                 235                 240 


Val Arg Gln Lys Ile Met Gln Ala Ala Xaa Pro Xaa Glu Gln Pro Pro 
                245                 250                 255     


Gly Ala Glu Ala Pro Leu Pro Val Pro Pro Pro Xaa Gly Xaa Ala Ala 
            260                 265                 270         


Ala Pro Ala Pro Xaa Pro Ser Pro Ala Gly Gly Pro Asp Pro Xaa Ser 
        275                 280                 285             


Pro Ser Ser Asp Ser Gly Xaa Ala Gln Ala Ala Pro Pro Leu Pro Pro 
    290                 295                 300                 


Pro Pro Glu Ser Gly 
305                 


<210> 6238
<211> 320
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<400> 6238
Xaa Glu Pro Pro Xaa Pro Pro Ser Pro Ala Pro Ala Pro Ala Val Ala 
1               5                   10                  15      


Pro Gly Gly Ser Ser Glu Ser Ser Ser Gly Arg Ala Ala Gly Asp Xaa 
            20                  25                  30          


Pro Glu Arg Lys Glu Ala Ala Gly Xaa Gly Lys Lys Val Lys Val Arg 
        35                  40                  45              


Pro Pro Pro Leu Lys Lys Xaa Phe Asp Ser Val Asp Asn Arg Val Leu 
    50                  55                  60                  


Ser Glu Val Asp Phe Glu Glu Arg Phe Ala Glu Leu Pro Glu Phe Arg 
65                  70                  75                  80  


Pro Glu Glu Val Leu Pro Ser Pro Xaa Leu Gln Ser Leu Ala Xaa Ser 
                85                  90                  95      


Pro Arg Ala Ile Leu Gly Ser Tyr Arg Lys Lys Arg Lys Asn Ser Xaa 
            100                 105                 110         


Asp Leu Asp Ser Ala Pro Glu Asp Pro Xaa Ser Pro Lys Arg Lys Met 
        115                 120                 125             


Arg Arg Arg Ser Ser Cys Ser Ser Glu Pro Asn Xaa Pro Lys Ser Ala 
    130                 135                 140                 


Lys Cys Glu Gly Asp Ile Phe Xaa Phe Asp Arg Xaa Glu Ala Glu Asp 
145                 150                 155                 160 


Val Leu Gly Glu Leu Glu Tyr Asp Lys Val Pro Tyr Ser Ser Leu Arg 
                165                 170                 175     


Arg Xaa Leu Asp Gln Arg Arg Ala Leu Val Met Gln Leu Phe Gln Asp 
            180                 185                 190         


His Gly Phe Phe Pro Ser Ala Gln Ala Xaa Ala Ala Phe Gln Ala Arg 
        195                 200                 205             


Tyr Ala Asp Ile Phe Pro Ser Lys Val Cys Leu Gln Leu Lys Ile Arg 
    210                 215                 220                 


Glu Val Arg Gln Lys Ile Met Gln Ala Ala Xaa Pro Xaa Glu Gln Pro 
225                 230                 235                 240 


Pro Gly Ala Glu Ala Pro Leu Pro Val Pro Pro Pro Xaa Gly Xaa Ala 
                245                 250                 255     


Ala Ala Pro Ala Pro Xaa Pro Ser Pro Ala Gly Gly Pro Asp Pro Xaa 
            260                 265                 270         


Ser Pro Ser Ser Asp Ser Gly Xaa Ala Gln Ala Ala Pro Pro Leu Pro 
        275                 280                 285             


Pro Pro Pro Glu Ser Gly Pro Gly Gln Pro Gly Trp Glu Gly Ala Pro 
    290                 295                 300                 


Gln Pro Ser Pro Pro Pro Pro Gly Pro Ser Xaa Ala Ala Xaa Gly Arg 
305                 310                 315                 320 


<210> 6239
<211> 219
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<400> 6239
Met Glu Ala Ala Arg Asp Tyr Ala Gly Ala Leu Ile Arg Pro Leu Xaa 
1               5                   10                  15      


Phe Met Gly Ser Gln Xaa Lys Arg Val Leu Phe Xaa Pro Leu Met His 
            20                  25                  30          


Pro Ala Arg Pro Phe Arg Val Ser Asn His Asp Arg Ser Ser Arg Arg 
        35                  40                  45              


Gly Val Met Ala Ser Ser Leu Gln Glu Leu Ile Ser Lys Xaa Leu Asp 
    50                  55                  60                  


Ala Leu Val Ile Ala Xaa Gly Leu Val Xaa Leu Val Leu Glu Glu Asp 
65                  70                  75                  80  


Gly Xaa Val Val Asp Xaa Glu Glu Phe Phe Gln Xaa Leu Gly Asp Asn 
                85                  90                  95      


Xaa His Phe Met Ile Leu Glu Lys Gly Gln Lys Trp Met Pro Gly Ser 
            100                 105                 110         


Gln His Val Pro Xaa Cys Ser Pro Pro Lys Arg Ser Gly Ile Ala Arg 
        115                 120                 125             


Val Xaa Phe Asp Leu Tyr Arg Leu Asn Pro Lys Asp Phe Ile Gly Cys 
    130                 135                 140                 


Leu Asn Val Lys Ala Xaa Met Tyr Glu Met Tyr Ser Val Ser Tyr Asp 
145                 150                 155                 160 


Ile Arg Cys Xaa Gly Leu Lys Gly Leu Leu Arg Ser Leu Leu Arg Phe 
                165                 170                 175     


Leu Ser Tyr Ser Ala Gln Val Xaa Gly Gln Phe Leu Ile Tyr Leu Gly 
            180                 185                 190         


Xaa Tyr Met Leu Arg Val Leu Asp Asp Lys Glu Glu Arg Pro Ser Leu 
        195                 200                 205             


Arg Ser Gln Ala Lys Gly Arg Phe Xaa Cys Gly 
    210                 215                 


<210> 6240
<211> 200
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<400> 6240
Met Glu Ala Ala Arg Asp Tyr Ala Gly Ala Leu Ile Arg Arg Val Pro 
1               5                   10                  15      


Arg Val Pro Leu Ile Ala Val Arg Phe Gln Ser Pro Cys Val Arg Trp 
            20                  25                  30          


Pro His Ile Pro Leu Cys Ala Ser Ser Xaa Val Pro Arg Ser Leu Gln 
        35                  40                  45              


Pro Pro Ala Pro Arg Ile Leu Leu Arg Ser Ala Xaa Pro Arg Xaa His 
    50                  55                  60                  


Pro Ser Ala Pro Leu Val Pro Lys Pro Ser Ser Arg Ala Arg Gly Gln 
65                  70                  75                  80  


Ser Pro Ile Pro Ser Arg Ala Ser Ser Pro Ser Cys Ser Trp Ala Gln 
                85                  90                  95      


Val Pro Gly Val Ala Leu Ala Arg Cys Ala Gly Val Cys Lys Pro Gly 
            100                 105                 110         


Asp Ser Trp Arg Val Ala Ala Cys Ile Ser Gly Arg Cys Cys Ser Arg 
        115                 120                 125             


Gly Arg Arg Arg Gly Ser Gly Pro Arg Asn Pro Glu Gln Ser Phe Arg 
    130                 135                 140                 


Asp Ala Arg Gly Pro Gly Phe Trp Gly Ser Trp Lys Ser Gln Arg Glu 
145                 150                 155                 160 


Leu Gly Ala Gly Gly Ala Gln Ala Trp Pro Leu Leu Glu Ala Arg Ala 
                165                 170                 175     


Leu Val Ser Glu Gly Arg Pro Gln Pro Ser Gly Gly Ala Leu Gln Ala 
            180                 185                 190         


Pro Asp Ile Tyr Gly Ile Xaa Asp 
        195                 200 


<210> 6241
<211> 219
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<400> 6241
Met Glu Tyr Leu Ser Ala Leu Asn Pro Ser Asp Leu Leu Arg Ser Val 
1               5                   10                  15      


Ser Asn Ile Ser Ser Glu Phe Gly Arg Arg Val Trp Xaa Ser Ala Pro 
            20                  25                  30          


Pro Pro Gln Arg Pro Phe Arg Val Cys Asp His Lys Arg Xaa Ile Arg 
        35                  40                  45              


Lys Gly Leu Xaa Ala Ala Xaa Arg Gln Glu Leu Leu Ala Lys Ala Leu 
    50                  55                  60                  


Glu Xaa Leu Leu Leu Asn Gly Val Leu Xaa Leu Val Leu Glu Glu Asp 
65                  70                  75                  80  


Gly Xaa Ala Val Asp Ser Glu Asp Phe Phe Gln Leu Leu Glu Asp Asp 
                85                  90                  95      


Xaa Cys Leu Met Val Leu Gln Ser Gly Gln Ser Trp Ser Pro Xaa Arg 
            100                 105                 110         


Ser Gly Val Leu Ser Tyr Gly Leu Gly Arg Glu Arg Pro Lys His Ser 
        115                 120                 125             


Lys Asp Ile Ala Arg Phe Xaa Phe Asp Val Tyr Lys Gln Asn Pro Arg 
    130                 135                 140                 


Asp Leu Phe Gly Ser Leu Asn Val Lys Ala Xaa Phe Tyr Gly Leu Tyr 
145                 150                 155                 160 


Ser Met Ser Cys Asp Phe Gln Gly Leu Gly Pro Lys Lys Val Leu Arg 
                165                 170                 175     


Glu Leu Leu Arg Trp Xaa Ser Xaa Leu Leu Gln Gly Leu Gly His Met 
            180                 185                 190         


Leu Leu Gly Ile Ser Ser Xaa Leu Arg His Ala Val Glu Gly Ala Glu 
        195                 200                 205             


Gln Trp Gln Gln Lys Gly Arg Leu His Ser Tyr 
    210                 215                 


<210> 6242
<211> 61
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<400> 6242
Xaa Val Asp Ser Glu Asp Phe Phe Gln Leu Leu Glu Asp Asp Xaa Cys 
1               5                   10                  15      


Leu Met Val Leu Gln Ser Gly Gln Ser Trp Ser Pro Xaa Arg Gly Ala 
            20                  25                  30          


Pro Ser Leu Asp Leu His Xaa Ala Ala Arg Pro Gly Pro Tyr Val Ala 
        35                  40                  45              


Gly Asn Phe Leu His Pro Ser Ser Cys Ser Gly Gly Gly 
    50                  55                  60      


<210> 6243
<211> 139
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<400> 6243
Met Glu Leu Gly Pro Leu Glu Gly Gly Tyr Leu Glu Leu Leu Asn Ser 
1               5                   10                  15      


Asp Ala Asp Pro Leu Cys Leu Tyr His Phe Tyr Asp Gln Met Asp Leu 
            20                  25                  30          


Ala Gly Glu Glu Glu Ile Glu Leu Tyr Ser Glu Pro Asp Xaa Asp Xaa 
        35                  40                  45              


Ile Asn Cys Asp Gln Phe Ser Arg Leu Leu Cys Asp Met Glu Gly Asp 
    50                  55                  60                  


Glu Glu Xaa Arg Glu Ala Tyr Ala Asn Ile Ala Glu Leu Asp Gln Tyr 
65                  70                  75                  80  


Val Phe Gln Asp Ser Gln Leu Glu Gly Leu Ser Lys Asp Ile Phe Ile 
                85                  90                  95      


Glu His Ile Gly Pro Asp Glu Val Ile Gly Glu Ser Met Glu Met Pro 
            100                 105                 110         


Ala Glu Val Gly Gln Lys Ser Gln Lys Arg Pro Phe Pro Glu Glu Leu 
        115                 120                 125             


Pro Ala Asp Leu Lys His Trp Lys Pro Gly Val 
    130                 135                 


<210> 6244
<211> 177
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<400> 6244
Met Glu Leu Gly Pro Leu Glu Gly Gly Tyr Leu Glu Leu Leu Asn Ser 
1               5                   10                  15      


Asp Ala Asp Pro Leu Cys Leu Tyr His Phe Tyr Asp Gln Met Asp Leu 
            20                  25                  30          


Ala Gly Glu Glu Glu Ile Glu Leu Tyr Ser Glu Pro Asp Xaa Asp Xaa 
        35                  40                  45              


Ile Asn Cys Asp Gln Phe Ser Arg Leu Leu Cys Asp Met Glu Gly Asp 
    50                  55                  60                  


Glu Glu Xaa Arg Glu Ala Tyr Ala Asn Ile Ala Glu Leu Asp Gln Tyr 
65                  70                  75                  80  


Val Phe Gln Asp Ser Gln Leu Glu Gly Leu Ser Lys Asp Ile Phe Lys 
                85                  90                  95      


His Ile Gly Pro Asp Glu Val Ile Gly Glu Ser Met Glu Met Pro Ala 
            100                 105                 110         


Glu Val Gly Gln Lys Ser Gln Lys Arg Pro Phe Pro Glu Glu Leu Pro 
        115                 120                 125             


Ala Asp Leu Lys His Trp Lys Pro Ala Glu Pro Pro Xaa Val Val Xaa 
    130                 135                 140                 


Gly Ser Leu Leu Val Gly Pro Val Ser Asp Cys Ser Xaa Leu Pro Cys 
145                 150                 155                 160 


Leu Pro Leu Pro Ala Leu Phe Asn Gln Glu Pro Ala Ser Gly Gln Met 
                165                 170                 175     


Arg 
    


<210> 6245
<211> 261
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<400> 6245
Met Asn Asn Phe Gln Ala Ile Leu Xaa Gln Val Arg Met Leu Leu Ser 
1               5                   10                  15      


Ser His Gln Pro Ser Leu Val Gln Ala Leu Leu Asp Asn Leu Leu Lys 
            20                  25                  30          


Glu Asp Leu Leu Ser Arg Glu Tyr His Cys Xaa Leu Leu His Glu Pro 
        35                  40                  45              


Asp Ser Glu Ala Leu Ala Arg Lys Ile Ser Leu Xaa Leu Leu Glu Lys 
    50                  55                  60                  


Gly Asp Leu Asp Leu Ala Leu Leu Gly Trp Ala Arg Ser Gly Leu Gln 
65                  70                  75                  80  


Pro Pro Ala Ala Glu Arg Gly Pro Gly His Ser Asp His Gly Gly Ser 
                85                  90                  95      


Ser Gln Cys Ala Xaa Met Glu Leu Gly Pro Leu Glu Gly Gly Tyr Leu 
            100                 105                 110         


Glu Leu Leu Asn Ser Asp Ala Asp Pro Leu Cys Leu Tyr His Phe Tyr 
        115                 120                 125             


Asp Gln Met Asp Leu Ala Gly Glu Glu Glu Ile Glu Leu Tyr Ser Glu 
    130                 135                 140                 


Pro Asp Xaa Asp Xaa Ile Asn Cys Asp Gln Phe Ser Arg Leu Leu Cys 
145                 150                 155                 160 


Asp Met Glu Gly Asp Glu Glu Xaa Arg Glu Ala Tyr Ala Asn Ile Ala 
                165                 170                 175     


Glu Leu Asp Gln Tyr Val Phe Gln Asp Ser Gln Leu Glu Gly Leu Ser 
            180                 185                 190         


Lys Asp Ile Phe Ile Glu His Ile Gly Pro Asp Glu Val Ile Gly Glu 
        195                 200                 205             


Ser Met Glu Met Pro Ala Glu Val Gly Gln Lys Ser Gln Lys Arg Pro 
    210                 215                 220                 


Phe Pro Glu Glu Leu Pro Ala Asp Leu Lys His Trp Lys Pro Ala Glu 
225                 230                 235                 240 


Pro Pro Xaa Val Val Xaa Gly Ser Leu Leu Val Gly Pro Val Ser Asp 
                245                 250                 255     


Cys Ser Xaa Leu Pro 
            260     


<210> 6246
<211> 1131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1105)..(1105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<400> 6246
Met Arg Cys Leu Ala Pro Arg Pro Ala Gly Ser Tyr Leu Ser Glu Pro 
1               5                   10                  15      


Gln Gly Ser Ser Gln Cys Ala Xaa Met Glu Leu Gly Pro Leu Glu Gly 
            20                  25                  30          


Gly Tyr Leu Glu Leu Leu Asn Ser Asp Ala Asp Pro Leu Cys Leu Tyr 
        35                  40                  45              


His Phe Tyr Asp Gln Met Asp Leu Ala Gly Glu Glu Glu Ile Glu Leu 
    50                  55                  60                  


Tyr Ser Glu Pro Asp Xaa Asp Xaa Ile Asn Cys Asp Gln Phe Ser Arg 
65                  70                  75                  80  


Leu Leu Cys Asp Met Glu Gly Asp Glu Glu Xaa Arg Glu Ala Tyr Ala 
                85                  90                  95      


Asn Ile Ala Glu Leu Asp Gln Tyr Val Phe Gln Asp Ser Gln Leu Glu 
            100                 105                 110         


Gly Leu Ser Lys Asp Ile Phe Ile Glu His Ile Gly Pro Asp Glu Val 
        115                 120                 125             


Ile Gly Glu Ser Met Glu Met Pro Ala Glu Val Gly Gln Lys Ser Gln 
    130                 135                 140                 


Lys Arg Pro Phe Pro Glu Glu Leu Pro Ala Asp Leu Lys His Trp Lys 
145                 150                 155                 160 


Pro Ala Glu Pro Pro Xaa Val Val Xaa Gly Ser Leu Leu Val Gly Pro 
                165                 170                 175     


Val Ser Asp Cys Ser Xaa Leu Pro Cys Leu Pro Leu Pro Ala Leu Phe 
            180                 185                 190         


Asn Gln Glu Pro Ala Ser Gly Gln Met Arg Leu Glu Lys Xaa Asp Gln 
        195                 200                 205             


Ile Pro Met Pro Phe Ser Ser Ser Ser Leu Ser Cys Leu Asn Leu Pro 
    210                 215                 220                 


Glu Gly Pro Ile Gln Phe Val Pro Xaa Ile Ser Xaa Leu Pro His Gly 
225                 230                 235                 240 


Leu Trp Gln Ile Ser Glu Ala Gly Xaa Gly Val Ser Ser Ile Phe Ile 
                245                 250                 255     


Tyr His Gly Glu Val Pro Gln Ala Ser Gln Val Pro Pro Pro Ser Gly 
            260                 265                 270         


Phe Xaa Val His Gly Leu Pro Xaa Ser Pro Asp Arg Pro Gly Ser Xaa 
        275                 280                 285             


Ser Pro Phe Ala Pro Ser Ala Xaa Asp Leu Pro Ser Met Pro Glu Pro 
    290                 295                 300                 


Ala Leu Xaa Ser Arg Ala Asn Met Xaa Glu His Lys Xaa Ser Pro Xaa 
305                 310                 315                 320 


Gln Cys Pro Ala Ala Gly Glu Val Ser Asn Lys Leu Pro Lys Trp Pro 
                325                 330                 335     


Glu Pro Val Glu Gln Phe Tyr Arg Ser Leu Gln Asp Xaa Tyr Gly Ala 
            340                 345                 350         


Glu Pro Ala Gly Pro Asp Gly Ile Leu Val Glu Val Asp Leu Val Gln 
        355                 360                 365             


Ala Arg Leu Glu Arg Ser Ser Ser Lys Ser Leu Glu Arg Glu Leu Ala 
    370                 375                 380                 


Xaa Pro Asp Trp Ala Glu Arg Gln Leu Ala Gln Gly Gly Leu Ala Glu 
385                 390                 395                 400 


Val Leu Leu Ala Ala Lys Glu His Arg Arg Pro Arg Glu Xaa Arg Val 
                405                 410                 415     


Ile Ala Val Leu Gly Lys Ala Gly Gln Gly Lys Ser Tyr Trp Ala Gly 
            420                 425                 430         


Ala Val Ser Arg Ala Trp Ala Cys Gly Arg Leu Pro Gln Tyr Asp Phe 
        435                 440                 445             


Val Phe Ser Val Pro Cys His Cys Leu Asn Arg Pro Gly Asp Ala Tyr 
    450                 455                 460                 


Gly Leu Gln Asp Leu Leu Phe Ser Leu Gly Pro Gln Pro Leu Val Ala 
465                 470                 475                 480 


Ala Asp Glu Val Phe Ser His Ile Leu Lys Arg Pro Asp Arg Val Leu 
                485                 490                 495     


Leu Ile Leu Asp Gly Phe Glu Glu Leu Glu Ala Gln Asp Gly Phe Leu 
            500                 505                 510         


His Ser Xaa Cys Gly Pro Ala Pro Ala Glu Pro Cys Ser Leu Arg Gly 
        515                 520                 525             


Leu Leu Ala Gly Leu Phe Gln Lys Lys Leu Leu Arg Gly Cys Xaa Leu 
    530                 535                 540                 


Leu Leu Xaa Ala Arg Pro Arg Gly Arg Leu Val Gln Ser Leu Ser Lys 
545                 550                 555                 560 


Ala Asp Ala Leu Phe Glu Leu Ser Gly Phe Ser Met Glu Gln Ala Gln 
                565                 570                 575     


Ala Tyr Val Met Arg Tyr Phe Glu Ser Ser Gly Met Xaa Glu His Gln 
            580                 585                 590         


Asp Arg Ala Leu Xaa Leu Leu Arg Asp Arg Pro Leu Leu Leu Ser His 
        595                 600                 605             


Ser His Ser Pro Xaa Leu Cys Arg Ala Val Cys Gln Leu Ser Glu Ala 
    610                 615                 620                 


Leu Leu Glu Leu Gly Glu Asp Ala Lys Leu Pro Ser Xaa Leu Xaa Gly 
625                 630                 635                 640 


Leu Tyr Val Gly Leu Leu Gly Arg Ala Ala Leu Asp Ser Pro Pro Gly 
                645                 650                 655     


Ala Leu Ala Glu Leu Ala Lys Leu Ala Trp Glu Leu Gly Arg Arg His 
            660                 665                 670         


Gln Ser Xaa Leu Gln Glu Asp Gln Phe Pro Ser Ala Asp Val Arg Xaa 
        675                 680                 685             


Trp Ala Met Ala Lys Gly Leu Val Gln His Pro Pro Arg Ala Ala Glu 
    690                 695                 700                 


Ser Glu Leu Ala Phe Pro Ser Phe Leu Leu Gln Cys Phe Leu Gly Ala 
705                 710                 715                 720 


Leu Trp Leu Ala Leu Ser Gly Glu Ile Lys Asp Lys Glu Leu Pro Gln 
                725                 730                 735     


Tyr Leu Ala Leu Xaa Pro Arg Lys Lys Arg Pro Tyr Asp Asn Trp Leu 
            740                 745                 750         


Glu Gly Val Pro Arg Phe Leu Ala Gly Leu Ile Phe Gln Pro Pro Ala 
        755                 760                 765             


Arg Cys Leu Gly Ala Leu Leu Gly Pro Ser Ala Ala Ala Ser Val Asp 
    770                 775                 780                 


Arg Lys Gln Lys Val Leu Ala Arg Tyr Leu Lys Arg Leu Gln Pro Gly 
785                 790                 795                 800 


Xaa Leu Arg Ala Arg Gln Leu Leu Glu Leu Leu His Cys Ala His Glu 
                805                 810                 815     


Ala Glu Glu Ala Gly Ile Trp Gln His Val Val Gln Glu Leu Pro Gly 
            820                 825                 830         


Arg Leu Ser Phe Leu Gly Xaa Arg Leu Xaa Pro Pro Asp Ala His Val 
        835                 840                 845             


Leu Gly Lys Ala Leu Glu Ala Ala Gly Gln Asp Phe Ser Leu Asp Leu 
    850                 855                 860                 


Arg Ser Xaa Gly Ile Cys Pro Ser Gly Leu Gly Ser Leu Val Gly Leu 
865                 870                 875                 880 


Ser Cys Val Xaa Arg Phe Arg Ala Ala Leu Ser Asp Xaa Val Ala Leu 
                885                 890                 895     


Trp Glu Ser Leu Gln Gln His Gly Glu Xaa Lys Leu Leu Gln Ala Ala 
            900                 905                 910         


Glu Glu Lys Phe Xaa Ile Glu Pro Phe Lys Ala Lys Ser Leu Lys Asp 
        915                 920                 925             


Val Glu Asp Leu Gly Lys Leu Val Gln Xaa Gln Arg Xaa Arg Ser Ser 
    930                 935                 940                 


Ser Glu Asp Xaa Ala Gly Glu Leu Pro Ala Val Arg Asp Leu Lys Lys 
945                 950                 955                 960 


Leu Glu Phe Ala Leu Gly Pro Val Ser Gly Pro Gln Ala Phe Pro Lys 
                965                 970                 975     


Leu Val Arg Ile Leu Xaa Ala Phe Ser Ser Leu Gln His Leu Asp Leu 
            980                 985                 990         


Asp Ala Leu Ser Glu Asn Lys Ile  Gly Asp Glu Gly Val  Ser Gln Leu 
        995                 1000                 1005             


Ser Ala  Xaa Phe Pro Gln Leu  Lys Ser Leu Glu Xaa  Leu Asn Leu 
    1010                 1015                 1020             


Ser Gln  Asn Asn Ile Xaa Asp  Leu Gly Ala Tyr Lys  Leu Ala Glu 
    1025                 1030                 1035             


Ala Leu  Pro Ser Leu Ala Ala  Ser Leu Leu Arg Leu  Ser Leu Tyr 
    1040                 1045                 1050             


Asn Asn  Cys Ile Cys Asp Val  Gly Ala Glu Ser Leu  Ala Arg Val 
    1055                 1060                 1065             


Leu Pro  Asp Met Val Ser Leu  Arg Val Met Asp Val  Gln Tyr Asn 
    1070                 1075                 1080             


Lys Phe  Xaa Ala Ala Gly Ala  Gln Gln Leu Ala Ala  Ser Leu Arg 
    1085                 1090                 1095             


Arg Cys  Pro His Val Glu Xaa  Leu Ala Met Trp Xaa  Pro Xaa Ile 
    1100                 1105                 1110             


Pro Phe  Ser Val Gln Glu His  Leu Gln Gln Gln Asp  Ser Arg Ile 
    1115                 1120                 1125             


Ser Leu  Arg 
    1130     


<210> 6247
<211> 353
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<400> 6247
Met Arg Cys Leu Ala Pro Arg Pro Ala Gly Ser Tyr Leu Ser Glu Pro 
1               5                   10                  15      


Gln Gly Ser Ser Gln Cys Ala Xaa Met Glu Leu Gly Pro Leu Glu Gly 
            20                  25                  30          


Gly Tyr Leu Glu Leu Leu Asn Ser Asp Ala Asp Pro Leu Cys Leu Tyr 
        35                  40                  45              


His Phe Tyr Asp Gln Met Asp Leu Ala Gly Glu Glu Glu Ile Glu Leu 
    50                  55                  60                  


Tyr Ser Glu Pro Asp Xaa Asp Xaa Ile Asn Cys Asp Gln Phe Ser Arg 
65                  70                  75                  80  


Leu Leu Cys Asp Met Glu Gly Asp Glu Glu Xaa Arg Glu Ala Tyr Ala 
                85                  90                  95      


Asn Ile Ala Glu Leu Asp Gln Tyr Val Phe Gln Asp Ser Gln Leu Glu 
            100                 105                 110         


Gly Leu Ser Lys Asp Ile Phe Lys His Ile Gly Pro Asp Glu Val Ile 
        115                 120                 125             


Gly Glu Ser Met Glu Met Pro Ala Glu Val Gly Gln Lys Ser Gln Lys 
    130                 135                 140                 


Arg Pro Phe Pro Glu Glu Leu Pro Ala Asp Leu Lys His Trp Lys Pro 
145                 150                 155                 160 


Ala Glu Pro Pro Xaa Val Val Xaa Gly Ser Leu Leu Val Gly Pro Val 
                165                 170                 175     


Ser Asp Cys Ser Xaa Leu Pro Cys Leu Pro Leu Pro Ala Leu Phe Asn 
            180                 185                 190         


Gln Glu Pro Ala Ser Gly Gln Met Arg Leu Glu Lys Xaa Asp Gln Ile 
        195                 200                 205             


Pro Met Pro Phe Ser Ser Ser Ser Leu Ser Cys Leu Asn Leu Pro Glu 
    210                 215                 220                 


Gly Pro Ile Gln Phe Val Pro Xaa Ile Ser Xaa Leu Pro His Gly Leu 
225                 230                 235                 240 


Trp Gln Ile Ser Glu Ala Gly Xaa Gly Val Ser Ser Ile Phe Ile Tyr 
                245                 250                 255     


His Gly Glu Val Pro Gln Ala Ser Gln Val Pro Pro Pro Ser Gly Phe 
            260                 265                 270         


Xaa Val His Gly Leu Pro Xaa Ser Pro Asp Arg Pro Gly Ser Xaa Ser 
        275                 280                 285             


Pro Phe Ala Pro Ser Ala Xaa Asp Leu Pro Ser Met Pro Glu Pro Ala 
    290                 295                 300                 


Leu Xaa Ser Arg Ala Asn Met Xaa Glu His Lys Xaa Ser Pro Xaa Gln 
305                 310                 315                 320 


Cys Pro Ala Ala Gly Glu Val Ser Asn Lys Leu Pro Lys Trp Pro Gly 
                325                 330                 335     


Arg Glu Val Pro Arg Lys Xaa Gln Leu Gly Ser Ser Leu Leu Phe Gly 
            340                 345                 350         


Xaa 
    


<210> 6248
<211> 1130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1104)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<400> 6248
Met Arg Cys Leu Ala Pro Arg Pro Ala Gly Ser Tyr Leu Ser Glu Pro 
1               5                   10                  15      


Gln Gly Ser Ser Gln Cys Ala Xaa Met Glu Leu Gly Pro Leu Glu Gly 
            20                  25                  30          


Gly Tyr Leu Glu Leu Leu Asn Ser Asp Ala Asp Pro Leu Cys Leu Tyr 
        35                  40                  45              


His Phe Tyr Asp Gln Met Asp Leu Ala Gly Glu Glu Glu Ile Glu Leu 
    50                  55                  60                  


Tyr Ser Glu Pro Asp Xaa Asp Xaa Ile Asn Cys Asp Gln Phe Ser Arg 
65                  70                  75                  80  


Leu Leu Cys Asp Met Glu Gly Asp Glu Glu Xaa Arg Glu Ala Tyr Ala 
                85                  90                  95      


Asn Ile Ala Glu Leu Asp Gln Tyr Val Phe Gln Asp Ser Gln Leu Glu 
            100                 105                 110         


Gly Leu Ser Lys Asp Ile Phe Lys His Ile Gly Pro Asp Glu Val Ile 
        115                 120                 125             


Gly Glu Ser Met Glu Met Pro Ala Glu Val Gly Gln Lys Ser Gln Lys 
    130                 135                 140                 


Arg Pro Phe Pro Glu Glu Leu Pro Ala Asp Leu Lys His Trp Lys Pro 
145                 150                 155                 160 


Ala Glu Pro Pro Xaa Val Val Xaa Gly Ser Leu Leu Val Gly Pro Val 
                165                 170                 175     


Ser Asp Cys Ser Xaa Leu Pro Cys Leu Pro Leu Pro Ala Leu Phe Asn 
            180                 185                 190         


Gln Glu Pro Ala Ser Gly Gln Met Arg Leu Glu Lys Xaa Asp Gln Ile 
        195                 200                 205             


Pro Met Pro Phe Ser Ser Ser Ser Leu Ser Cys Leu Asn Leu Pro Glu 
    210                 215                 220                 


Gly Pro Ile Gln Phe Val Pro Xaa Ile Ser Xaa Leu Pro His Gly Leu 
225                 230                 235                 240 


Trp Gln Ile Ser Glu Ala Gly Xaa Gly Val Ser Ser Ile Phe Ile Tyr 
                245                 250                 255     


His Gly Glu Val Pro Gln Ala Ser Gln Val Pro Pro Pro Ser Gly Phe 
            260                 265                 270         


Xaa Val His Gly Leu Pro Xaa Ser Pro Asp Arg Pro Gly Ser Xaa Ser 
        275                 280                 285             


Pro Phe Ala Pro Ser Ala Xaa Asp Leu Pro Ser Met Pro Glu Pro Ala 
    290                 295                 300                 


Leu Xaa Ser Arg Ala Asn Met Xaa Glu His Lys Xaa Ser Pro Xaa Gln 
305                 310                 315                 320 


Cys Pro Ala Ala Gly Glu Val Ser Asn Lys Leu Pro Lys Trp Pro Glu 
                325                 330                 335     


Pro Val Glu Gln Phe Tyr Arg Ser Leu Gln Asp Xaa Tyr Gly Ala Glu 
            340                 345                 350         


Pro Ala Gly Pro Asp Gly Ile Leu Val Glu Val Asp Leu Val Gln Ala 
        355                 360                 365             


Arg Leu Glu Arg Ser Ser Ser Lys Ser Leu Glu Arg Glu Leu Ala Xaa 
    370                 375                 380                 


Pro Asp Trp Ala Glu Arg Gln Leu Ala Gln Gly Gly Leu Ala Glu Val 
385                 390                 395                 400 


Leu Leu Ala Ala Lys Glu His Arg Arg Pro Arg Glu Xaa Arg Val Ile 
                405                 410                 415     


Ala Val Leu Gly Lys Ala Gly Gln Gly Lys Ser Tyr Trp Ala Gly Ala 
            420                 425                 430         


Val Ser Arg Ala Trp Ala Cys Gly Arg Leu Pro Gln Tyr Asp Phe Val 
        435                 440                 445             


Phe Ser Val Pro Cys His Cys Leu Asn Arg Pro Gly Asp Ala Tyr Gly 
    450                 455                 460                 


Leu Gln Asp Leu Leu Phe Ser Leu Gly Pro Gln Pro Leu Val Ala Ala 
465                 470                 475                 480 


Asp Glu Val Phe Ser His Ile Leu Lys Arg Pro Asp Arg Val Leu Leu 
                485                 490                 495     


Ile Leu Asp Gly Phe Glu Glu Leu Glu Ala Gln Asp Gly Phe Leu His 
            500                 505                 510         


Ser Xaa Cys Gly Pro Ala Pro Ala Glu Pro Cys Ser Leu Arg Gly Leu 
        515                 520                 525             


Leu Ala Gly Leu Phe Gln Lys Lys Leu Leu Arg Gly Cys Xaa Leu Leu 
    530                 535                 540                 


Leu Xaa Ala Arg Pro Arg Gly Arg Leu Val Gln Ser Leu Ser Lys Ala 
545                 550                 555                 560 


Asp Ala Leu Phe Glu Leu Ser Gly Phe Ser Met Glu Gln Ala Gln Ala 
                565                 570                 575     


Tyr Val Met Arg Tyr Phe Glu Ser Ser Gly Met Xaa Glu His Gln Asp 
            580                 585                 590         


Arg Ala Leu Xaa Leu Leu Arg Asp Arg Pro Leu Leu Leu Ser His Ser 
        595                 600                 605             


His Ser Pro Xaa Leu Cys Arg Ala Val Cys Gln Leu Ser Glu Ala Leu 
    610                 615                 620                 


Leu Glu Leu Gly Glu Asp Ala Lys Leu Pro Ser Xaa Leu Xaa Gly Leu 
625                 630                 635                 640 


Tyr Val Gly Leu Leu Gly Arg Ala Ala Leu Asp Ser Pro Pro Gly Ala 
                645                 650                 655     


Leu Ala Glu Leu Ala Lys Leu Ala Trp Glu Leu Gly Arg Arg His Gln 
            660                 665                 670         


Ser Xaa Leu Gln Glu Asp Gln Phe Pro Ser Ala Asp Val Arg Xaa Trp 
        675                 680                 685             


Ala Met Ala Lys Gly Leu Val Gln His Pro Pro Arg Ala Ala Glu Ser 
    690                 695                 700                 


Glu Leu Ala Phe Pro Ser Phe Leu Leu Gln Cys Phe Leu Gly Ala Leu 
705                 710                 715                 720 


Trp Leu Ala Leu Ser Gly Glu Ile Lys Asp Lys Glu Leu Pro Gln Tyr 
                725                 730                 735     


Leu Ala Leu Xaa Pro Arg Lys Lys Arg Pro Tyr Asp Asn Trp Leu Glu 
            740                 745                 750         


Gly Val Pro Arg Phe Leu Ala Gly Leu Ile Phe Gln Pro Pro Ala Arg 
        755                 760                 765             


Cys Leu Gly Ala Leu Leu Gly Pro Ser Ala Ala Ala Ser Val Asp Arg 
    770                 775                 780                 


Lys Gln Lys Val Leu Ala Arg Tyr Leu Lys Arg Leu Gln Pro Gly Xaa 
785                 790                 795                 800 


Leu Arg Ala Arg Gln Leu Leu Glu Leu Leu His Cys Ala His Glu Ala 
                805                 810                 815     


Glu Glu Ala Gly Ile Trp Gln His Val Val Gln Glu Leu Pro Gly Arg 
            820                 825                 830         


Leu Ser Phe Leu Gly Xaa Arg Leu Xaa Pro Pro Asp Ala His Val Leu 
        835                 840                 845             


Gly Lys Ala Leu Glu Ala Ala Gly Gln Asp Phe Ser Leu Asp Leu Arg 
    850                 855                 860                 


Ser Xaa Gly Ile Cys Pro Ser Gly Leu Gly Ser Leu Val Gly Leu Ser 
865                 870                 875                 880 


Cys Val Xaa Arg Phe Arg Ala Ala Leu Ser Asp Xaa Val Ala Leu Trp 
                885                 890                 895     


Glu Ser Leu Gln Gln His Gly Glu Xaa Lys Leu Leu Gln Ala Ala Glu 
            900                 905                 910         


Glu Lys Phe Xaa Ile Glu Pro Phe Lys Ala Lys Ser Leu Lys Asp Val 
        915                 920                 925             


Glu Asp Leu Gly Lys Leu Val Gln Xaa Gln Arg Xaa Arg Ser Ser Ser 
    930                 935                 940                 


Glu Asp Xaa Ala Gly Glu Leu Pro Ala Val Arg Asp Leu Lys Lys Leu 
945                 950                 955                 960 


Glu Phe Ala Leu Gly Pro Val Ser Gly Pro Gln Ala Phe Pro Lys Leu 
                965                 970                 975     


Val Arg Ile Leu Xaa Ala Phe Ser Ser Leu Gln His Leu Asp Leu Asp 
            980                 985                 990         


Ala Leu Ser Glu Asn Lys Ile Gly  Asp Glu Gly Val Ser  Gln Leu Ser 
        995                 1000                 1005             


Ala Xaa  Phe Pro Gln Leu Lys  Ser Leu Glu Xaa Leu  Asn Leu Ser 
    1010                 1015                 1020             


Gln Asn  Asn Ile Xaa Asp Leu  Gly Ala Tyr Lys Leu  Ala Glu Ala 
    1025                 1030                 1035             


Leu Pro  Ser Leu Ala Ala Ser  Leu Leu Arg Leu Ser  Leu Tyr Asn 
    1040                 1045                 1050             


Asn Cys  Ile Cys Asp Val Gly  Ala Glu Ser Leu Ala  Arg Val Leu 
    1055                 1060                 1065             


Pro Asp  Met Val Ser Leu Arg  Val Met Asp Val Gln  Tyr Asn Lys 
    1070                 1075                 1080             


Phe Xaa  Ala Ala Gly Ala Gln  Gln Leu Ala Ala Ser  Leu Arg Arg 
    1085                 1090                 1095             


Cys Pro  His Val Glu Xaa Leu  Ala Met Trp Xaa Pro  Xaa Ile Pro 
    1100                 1105                 1110             


Phe Ser  Val Gln Glu His Leu  Gln Gln Gln Asp Ser  Arg Ile Ser 
    1115                 1120                 1125             


Leu Arg  
    1130 


<210> 6249
<211> 172
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<400> 6249
Met Arg Cys Leu Ala Pro Arg Pro Ala Gly Ser Tyr Leu Ser Glu Pro 
1               5                   10                  15      


Gln Gly Ser Ser Gln Cys Ala Xaa Met Glu Leu Gly Pro Leu Glu Gly 
            20                  25                  30          


Gly Tyr Leu Glu Leu Leu Asn Ser Asp Ala Asp Pro Leu Cys Leu Tyr 
        35                  40                  45              


His Phe Tyr Asp Gln Met Asp Leu Ala Gly Glu Glu Glu Ile Glu Leu 
    50                  55                  60                  


Tyr Ser Glu Pro Asp Xaa Asp Xaa Ile Asn Cys Asp Gln Phe Ser Arg 
65                  70                  75                  80  


Leu Leu Cys Asp Met Glu Gly Asp Glu Glu Xaa Arg Glu Ala Tyr Ala 
                85                  90                  95      


Asn Ile Ala Glu Leu Asp Gln Tyr Val Phe Gln Asp Ser Gln Leu Glu 
            100                 105                 110         


Gly Leu Ser Lys Asp Ile Phe Lys His Ile Gly Pro Asp Glu Val Ile 
        115                 120                 125             


Gly Glu Ser Met Glu Met Pro Ala Glu Val Gly Gln Lys Ser Gln Lys 
    130                 135                 140                 


Arg Pro Phe Pro Glu Glu Leu Pro Ala Asp Leu Lys His Trp Lys Pro 
145                 150                 155                 160 


Ala Leu Arg Val Glu Ala Leu Gly Ser Cys Ser Ala 
                165                 170         


<210> 6250
<211> 546
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<400> 6250
Met Arg Cys Leu Ala Pro Arg Pro Ala Gly Ser Tyr Leu Ser Glu Pro 
1               5                   10                  15      


Gln Gly Ser Ser Gln Cys Ala Xaa Met Glu Leu Gly Pro Leu Glu Gly 
            20                  25                  30          


Gly Tyr Leu Glu Leu Leu Asn Ser Asp Ala Asp Pro Leu Cys Leu Tyr 
        35                  40                  45              


His Phe Tyr Asp Gln Met Asp Leu Ala Gly Glu Glu Glu Ile Glu Leu 
    50                  55                  60                  


Tyr Ser Glu Pro Asp Xaa Asp Xaa Ile Asn Cys Asp Gln Phe Ser Arg 
65                  70                  75                  80  


Leu Leu Cys Asp Met Glu Gly Asp Glu Glu Xaa Arg Glu Ala Tyr Ala 
                85                  90                  95      


Asn Ile Ala Glu Leu Asp Gln Tyr Val Phe Gln Asp Ser Gln Leu Glu 
            100                 105                 110         


Gly Leu Ser Lys Asp Ile Phe Lys His Ile Gly Pro Asp Glu Val Ile 
        115                 120                 125             


Gly Glu Ser Met Glu Met Pro Ala Glu Val Gly Gln Lys Ser Gln Lys 
    130                 135                 140                 


Arg Pro Phe Pro Glu Glu Leu Pro Ala Asp Leu Lys His Trp Lys Pro 
145                 150                 155                 160 


Val Pro Phe Ser Ser Ser Ser Leu Ser Cys Leu Asn Leu Pro Glu Gly 
                165                 170                 175     


Pro Ile Gln Phe Val Pro Xaa Ile Ser Xaa Leu Pro His Gly Leu Trp 
            180                 185                 190         


Gln Ile Ser Glu Ala Gly Xaa Gly Val Ser Ser Ile Phe Ile Tyr His 
        195                 200                 205             


Gly Glu Val Pro Gln Ala Ser Gln Val Pro Pro Pro Ser Gly Phe Xaa 
    210                 215                 220                 


Val His Gly Leu Pro Xaa Ser Pro Asp Arg Pro Gly Ser Xaa Ser Pro 
225                 230                 235                 240 


Phe Ala Pro Ser Ala Xaa Asp Leu Pro Ser Met Pro Glu Pro Ala Leu 
                245                 250                 255     


Xaa Ser Arg Ala Asn Met Xaa Glu His Lys Xaa Ser Pro Xaa Gln Cys 
            260                 265                 270         


Pro Ala Ala Gly Glu Val Ser Asn Lys Leu Pro Lys Trp Pro Gly Leu 
        275                 280                 285             


Ala Trp Ser Pro Cys Leu Gly Leu Arg Pro Ser Leu His Arg Ala Ala 
    290                 295                 300                 


Leu Ser Asp Xaa Val Ala Leu Trp Glu Ser Leu Gln Gln His Gly Glu 
305                 310                 315                 320 


Xaa Lys Leu Leu Gln Ala Ala Glu Glu Lys Phe Xaa Ile Glu Pro Phe 
                325                 330                 335     


Lys Ala Lys Ser Leu Lys Asp Val Glu Asp Leu Gly Lys Leu Val Gln 
            340                 345                 350         


Xaa Gln Arg Xaa Arg Ser Ser Ser Glu Asp Xaa Ala Gly Glu Leu Pro 
        355                 360                 365             


Ala Val Arg Asp Leu Lys Lys Leu Glu Phe Ala Leu Gly Pro Val Ser 
    370                 375                 380                 


Gly Pro Gln Ala Phe Pro Lys Leu Val Arg Ile Leu Xaa Ala Phe Ser 
385                 390                 395                 400 


Ser Leu Gln His Leu Asp Leu Asp Ala Leu Ser Glu Asn Lys Ile Gly 
                405                 410                 415     


Asp Glu Gly Val Ser Gln Leu Ser Ala Xaa Phe Pro Gln Leu Lys Ser 
            420                 425                 430         


Leu Glu Xaa Leu Asn Leu Ser Gln Asn Asn Ile Xaa Asp Leu Gly Ala 
        435                 440                 445             


Tyr Lys Leu Ala Glu Ala Leu Pro Ser Leu Ala Ala Ser Leu Leu Arg 
    450                 455                 460                 


Leu Ser Leu Tyr Asn Asn Cys Ile Cys Asp Val Gly Ala Glu Ser Leu 
465                 470                 475                 480 


Ala Arg Val Leu Pro Asp Met Val Ser Leu Arg Val Met Asp Val Gln 
                485                 490                 495     


Tyr Asn Lys Phe Xaa Ala Ala Gly Ala Gln Gln Leu Ala Ala Ser Leu 
            500                 505                 510         


Arg Arg Cys Pro His Val Glu Xaa Leu Ala Met Trp Xaa Pro Xaa Ile 
        515                 520                 525             


Pro Phe Ser Val Gln Glu His Leu Gln Gln Gln Asp Ser Arg Ile Ser 
    530                 535                 540                 


Leu Arg 
545     


<210> 6251
<211> 1184
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1058)..(1058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1086)..(1086)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1145)..(1145)
<223> Selenocysteine

<400> 6251
Met Val Gly Xaa Lys Ala Trp Val Phe Ser Phe Leu Val Leu Glu Val 
1               5                   10                  15      


Xaa Ser Val Leu Gly Arg Gln Xaa Met Leu Xaa Gln Ser Val Arg Arg 
            20                  25                  30          


Val Gln Pro Gly Lys Lys Asn Pro Ser Ile Phe Ala Lys Pro Ala Asp 
        35                  40                  45              


Xaa Leu Glu Ser Pro Gly Glu Trp Xaa Xaa Trp Phe Asn Ile Asp Tyr 
    50                  55                  60                  


Pro Gly Gly Lys Gly Asp Tyr Glu Arg Leu Asp Ala Ile Arg Phe Tyr 
65                  70                  75                  80  


Tyr Gly Asp Arg Val Cys Ala Arg Pro Leu Arg Leu Glu Ala Arg Xaa 
                85                  90                  95      


Xaa Asp Trp Xaa Pro Ala Gly Ser Xaa Gly Gln Val Val His Gly Ser 
            100                 105                 110         


Pro Arg Glu Gly Phe Trp Cys Leu Asn Arg Glu Gln Arg Pro Gly Gln 
        115                 120                 125             


Asn Cys Ser Asn Tyr Xaa Val Arg Phe Leu Cys Pro Pro Gly Ser Leu 
    130                 135                 140                 


Arg Arg Asp Xaa Glu Arg Ile Trp Ser Pro Trp Ser Pro Trp Ser Lys 
145                 150                 155                 160 


Cys Ser Ala Ala Cys Gly Gln Xaa Gly Val Gln Xaa Arg Xaa Arg Ile 
                165                 170                 175     


Cys Leu Ala Glu Met Val Ser Leu Cys Ser Glu Ala Ser Glu Glu Gly 
            180                 185                 190         


Gln His Cys Met Gly Gln Asp Cys Xaa Ala Cys Asp Leu Xaa Cys Pro 
        195                 200                 205             


Met Gly Gln Val Asn Ala Asp Cys Asp Ala Cys Met Cys Gln Asp Phe 
    210                 215                 220                 


Met Leu His Gly Ala Val Ser Leu Pro Gly Gly Ala Pro Ala Ser Gly 
225                 230                 235                 240 


Ala Ala Ile Tyr Leu Leu Xaa Lys Xaa Pro Lys Leu Leu Xaa Gln Xaa 
                245                 250                 255     


Asp Ser Asp Gly Arg Phe Arg Ile Pro Gly Leu Cys Pro Asp Gly Lys 
            260                 265                 270         


Ser Ile Leu Lys Ile Xaa Lys Val Lys Phe Ala Pro Ile Val Leu Xaa 
        275                 280                 285             


Met Pro Lys Xaa Ser Leu Lys Ala Ala Xaa Ile Lys Ala Glu Phe Val 
    290                 295                 300                 


Arg Ala Glu Xaa Pro Tyr Met Val Met Asn Pro Glu Xaa Lys Ala Arg 
305                 310                 315                 320 


Arg Ala Gly Gln Ser Val Ser Leu Cys Cys Lys Ala Xaa Gly Lys Pro 
                325                 330                 335     


Arg Pro Asp Lys Tyr Phe Trp Tyr His Asn Asp Xaa Leu Leu Asp Pro 
            340                 345                 350         


Ser Leu Tyr Lys His Glu Ser Lys Leu Val Leu Arg Lys Leu Gln Gln 
        355                 360                 365             


His Gln Ala Gly Glu Tyr Phe Cys Lys Ala Gln Ser Asp Ala Gly Ala 
    370                 375                 380                 


Val Lys Ser Lys Val Ala Gln Leu Ile Val Ile Ala Ser Asp Glu Xaa 
385                 390                 395                 400 


Pro Cys Asn Pro Val Pro Glu Ser Tyr Leu Ile Arg Leu Pro His Asp 
                405                 410                 415     


Cys Phe Gln Asn Ala Xaa Asn Ser Phe Tyr Tyr Asp Val Gly Arg Cys 
            420                 425                 430         


Pro Val Lys Xaa Cys Ala Gly Gln Gln Asp Asn Gly Ile Arg Cys Arg 
        435                 440                 445             


Asp Ala Val Gln Asn Cys Cys Gly Ile Ser Lys Xaa Glu Glu Arg Glu 
    450                 455                 460                 


Ile Gln Cys Ser Gly Tyr Xaa Leu Pro Xaa Lys Val Ala Lys Glu Cys 
465                 470                 475                 480 


Ser Cys Gln Arg Cys Xaa Glu Xaa Arg Ser Ile Val Arg Gly Arg Val 
                485                 490                 495     


Ser Ala Ala Asp Asn Gly Glu Pro Met Arg Phe Gly His Val Tyr Met 
            500                 505                 510         


Gly Asn Ser Arg Val Ser Met Xaa Gly Tyr Lys Gly Xaa Phe Xaa Leu 
        515                 520                 525             


His Val Pro Gln Asp Xaa Glu Arg Leu Val Leu Xaa Phe Val Asp Arg 
    530                 535                 540                 


Leu Gln Lys Phe Val Asn Xaa Xaa Lys Val Leu Pro Phe Asn Lys Lys 
545                 550                 555                 560 


Gly Ser Ala Val Phe His Glu Ile Lys Met Leu Arg Arg Lys Lys Pro 
                565                 570                 575     


Ile Xaa Leu Glu Ala Met Glu Xaa Asn Ile Ile Pro Leu Gly Glu Val 
            580                 585                 590         


Val Gly Glu Asp Pro Met Ala Glu Leu Glu Ile Pro Ser Arg Ser Phe 
        595                 600                 605             


Tyr Arg Gln Asn Gly Glu Pro Tyr Ile Gly Lys Val Lys Ala Ser Val 
    610                 615                 620                 


Xaa Phe Leu Asp Pro Arg Asn Ile Ser Xaa Ala Xaa Ala Ala Gln Xaa 
625                 630                 635                 640 


Asp Leu Asn Phe Ile Asn Asp Glu Gly Asp Xaa Phe Pro Leu Arg Xaa 
                645                 650                 655     


Tyr Gly Met Phe Ser Val Asp Phe Arg Asp Glu Val Xaa Ser Glu Pro 
            660                 665                 670         


Leu Asn Ala Gly Lys Val Lys Val His Leu Asp Ser Xaa Gln Val Lys 
        675                 680                 685             


Met Pro Glu His Ile Ser Xaa Val Lys Leu Trp Ser Leu Asn Pro Asp 
    690                 695                 700                 


Xaa Gly Leu Trp Glu Glu Glu Gly Asp Phe Lys Phe Glu Asn Gln Arg 
705                 710                 715                 720 


Arg Asn Lys Arg Glu Asp Arg Xaa Phe Leu Val Gly Asn Leu Glu Ile 
                725                 730                 735     


Arg Glu Arg Arg Leu Phe Asn Leu Asp Val Pro Glu Ser Arg Arg Cys 
            740                 745                 750         


Phe Val Lys Val Arg Ala Tyr Arg Ser Glu Arg Phe Leu Pro Ser Glu 
        755                 760                 765             


Gln Ile Gln Gly Val Val Ile Ser Val Ile Asn Leu Glu Pro Arg Xaa 
    770                 775                 780                 


Gly Phe Leu Ser Asn Pro Arg Ala Trp Gly Arg Phe Asp Ser Val Ile 
785                 790                 795                 800 


Xaa Gly Pro Asn Gly Ala Cys Val Pro Ala Phe Cys Asp Asp Gln Ser 
                805                 810                 815     


Pro Asp Ala Tyr Ser Ala Tyr Val Leu Ala Ser Leu Ala Gly Glu Glu 
            820                 825                 830         


Leu Gln Ala Val Glu Ser Ser Pro Lys Phe Asn Pro Asn Ala Ile Gly 
        835                 840                 845             


Val Pro Gln Pro Tyr Leu Asn Lys Leu Asn Tyr Arg Arg Xaa Asp His 
    850                 855                 860                 


Glu Asp Pro Arg Val Lys Lys Xaa Ala Phe Gln Ile Ser Met Ala Lys 
865                 870                 875                 880 


Pro Arg Pro Asn Ser Ala Glu Glu Ser Asn Gly Pro Ile Tyr Ala Phe 
                885                 890                 895     


Glu Asn Leu Arg Ala Cys Glu Glu Ala Pro Pro Ser Ala Ala His Phe 
            900                 905                 910         


Arg Phe Tyr Gln Ile Glu Gly Asp Arg Tyr Asp Tyr Asn Xaa Val Pro 
        915                 920                 925             


Phe Asn Glu Asp Asp Pro Met Ser Trp Xaa Glu Asp Tyr Leu Ala Trp 
    930                 935                 940                 


Trp Pro Lys Pro Met Glu Phe Arg Ala Cys Tyr Ile Lys Val Lys Ile 
945                 950                 955                 960 


Val Gly Pro Leu Glu Val Asn Val Arg Ser Arg Asn Met Gly Gly Xaa 
                965                 970                 975     


His Arg Gln Xaa Val Gly Lys Leu Tyr Gly Ile Arg Asp Val Arg Ser 
            980                 985                 990         


Xaa Arg Asp Arg Asp Gln Pro Asn  Val Ser Ala Ala Cys  Leu Glu Phe 
        995                 1000                 1005             


Lys Cys  Ser Gly Met Leu Tyr  Asp Gln Asp Arg Val  Asp Arg Xaa 
    1010                 1015                 1020             


Leu Val  Lys Val Ile Pro Gln  Gly Ser Cys Arg Arg  Ala Ser Val 
    1025                 1030                 1035             


Asn Pro  Met Leu His Glu Tyr  Leu Val Asn His Leu  Pro Leu Ala 
    1040                 1045                 1050             


Val Asn  Asn Asp Xaa Ser Glu  Tyr Xaa Met Leu Ala  Pro Leu Asp 
    1055                 1060                 1065             


Pro Leu  Gly His Asn Tyr Gly  Ile Tyr Xaa Val Xaa  Asp Gln Asp 
    1070                 1075                 1080             


Pro Arg  Xaa Ala Lys Glu Ile  Ala Leu Gly Arg Cys  Phe Asp Gly 
    1085                 1090                 1095             


Xaa Ser  Asp Gly Ser Ser Arg  Ile Met Lys Ser Asn  Val Gly Val 
    1100                 1105                 1110             


Ala Leu  Xaa Phe Asn Cys Val  Glu Arg Gln Val Gly  Arg Gln Ser 
    1115                 1120                 1125             


Ala Phe  Gln Tyr Leu Gln Ser  Xaa Pro Ala Gln Ser  Pro Ala Ala 
    1130                 1135                 1140             


Gly Xaa  Val Gln Gly Arg Val  Pro Ser Arg Arg Gln  Gln Arg Ala 
    1145                 1150                 1155             


Ser Arg  Gly Gly Gln Arg Gln  Gly Gly Val Val Ala  Ser Leu Arg 
    1160                 1165                 1170             


Phe Pro  Arg Val Ala Gln Gln  Pro Leu Ile Asn 
    1175                 1180                 


<210> 6252
<211> 450
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<400> 6252
Met Gly Lys Ser Phe Ala Asn Phe Met Cys Lys Lys Asp Phe His Pro 
1               5                   10                  15      


Ala Ser Lys Ser Asn Ile Lys Lys Val Trp Met Ala Glu Gln Lys Ile 
            20                  25                  30          


Ser Tyr Asp Lys Lys Lys Gln Glu Glu Leu Met Gln Gln Tyr Leu Lys 
        35                  40                  45              


Glu Gln Glu Ser Tyr Asp Asn Arg Leu Leu Met Gly Asp Glu Arg Val 
    50                  55                  60                  


Lys Asn Gly Leu Asn Phe Met Tyr Glu Ala Pro Pro Gly Ala Lys Lys 
65                  70                  75                  80  


Glu Asn Lys Glu Lys Glu Glu Xaa Glu Gly Glu Xaa Glu Tyr Lys Phe 
                85                  90                  95      


Glu Trp Gln Lys Gly Ala Pro Arg Glu Lys Tyr Ala Lys Asp Asp Met 
            100                 105                 110         


Asn Ile Arg Asp Gln Pro Phe Gly Ile Gln Val Arg Asn Val Arg Cys 
        115                 120                 125             


Ile Lys Cys His Lys Trp Gly His Val Asn Xaa Asp Arg Glu Cys Pro 
    130                 135                 140                 


Leu Phe Gly Leu Ser Gly Ile Asn Ala Ser Ser Val Pro Xaa Asp Gly 
145                 150                 155                 160 


Ser Gly Pro Ser Met His Pro Ser Glu Leu Ile Ala Glu Met Arg Asn 
                165                 170                 175     


Ser Gly Phe Ala Leu Lys Arg Asn Val Leu Gly Arg Asn Leu Xaa Ala 
            180                 185                 190         


Asn Asp Pro Ser Gln Glu Tyr Val Ala Ser Glu Gly Glu Glu Asp Pro 
        195                 200                 205             


Glu Val Glu Phe Leu Lys Ser Leu Xaa Xaa Lys Gln Lys Gln Lys Leu 
    210                 215                 220                 


Leu Arg Lys Leu Asp Arg Leu Glu Lys Lys Lys Lys Lys Lys Asp Arg 
225                 230                 235                 240 


Lys Lys Lys Lys Phe Gln Lys Ser Arg Ser Lys His Lys Lys His Lys 
                245                 250                 255     


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Xaa Glu 
            260                 265                 270         


Xaa Ser Glu Ser Ser Ser Glu Ser Glu Ser Asn Asn Lys Glu Lys Lys 
        275                 280                 285             


Ile Gln Arg Lys Lys Arg Lys Lys Asn Lys Cys Ser Gly His Asn Asn 
    290                 295                 300                 


Ser Asp Ser Glu Glu Lys Asp Lys Ser Lys Lys Arg Lys Leu His Glu 
305                 310                 315                 320 


Glu Leu Ser Ser Ser His His Asn Arg Glu Lys Ala Lys Glu Lys Pro 
                325                 330                 335     


Arg Phe Leu Lys His Glu Ser Ser Arg Glu Asp Ser Lys Trp Ser His 
            340                 345                 350         


Ser Asp Ser Asp Lys Lys Ser Arg Xaa His Lys His Ser Pro Glu Lys 
        355                 360                 365             


Arg Gly Ser Glu Arg Lys Glu Gly Ser Ser Arg Ser His Gly Arg Glu 
    370                 375                 380                 


Glu Arg Ser Arg Arg Ser Arg Ser Arg Ser Pro Gly Ser Tyr Lys Gln 
385                 390                 395                 400 


Arg Glu Xaa Arg Lys Arg Ala Gln Arg Asn Pro Gly Glu Glu Gln Ser 
                405                 410                 415     


Arg Arg Asn Asp Ser Arg Ser His Gly Xaa Asp Leu Tyr Arg Gly Glu 
            420                 425                 430         


Lys Met Tyr Arg Glu His Pro Gly Gly Xaa His Xaa Lys Val Xaa Gln 
        435                 440                 445             


Arg Glu 
    450 


<210> 6253
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<400> 6253
Xaa Glu Trp Gln Lys Gly Ala Pro Arg Glu Lys Tyr Ala Lys Asp Asp 
1               5                   10                  15      


Met Asn Ile Arg Asp Gln Pro Phe Gly Ile Gln Val Arg Asn Val Arg 
            20                  25                  30          


Cys Ile Lys Cys His Lys Trp Gly His Val Asn Xaa Asp Arg Glu Cys 
        35                  40                  45              


Pro Leu Phe Gly Leu Ser Gly Ile Asn Ala Ser Ser Val Pro Xaa Asp 
    50                  55                  60                  


Gly Ser Gly Arg Ala Gln Trp Leu Xaa Pro Val Ile Pro Ala Leu Trp 
65                  70                  75                  80  


Glu Ala Lys Ala Gly Gly Ser Phe Glu Val Arg Ser Ser Arg Pro Ala 
                85                  90                  95      


<210> 6254
<211> 258
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<400> 6254
Met Val Leu Cys Val Gln Gly Pro Arg Pro Leu Leu Ala Val Glu Arg 
1               5                   10                  15      


Xaa Gly Gln Arg Pro Leu Trp Ala Pro Ser Leu Glu Leu Pro Lys Pro 
            20                  25                  30          


Val Met Gln Pro Leu Pro Ala Gly Ala Phe Leu Glu Glu Val Ala Glu 
        35                  40                  45              


Gly Xaa Pro Ala Gln Xaa Glu Ser Glu Pro Lys Val Leu Asp Pro Glu 
    50                  55                  60                  


Glu Asp Leu Leu Cys Ile Ala Lys Xaa Phe Ser Tyr Leu Arg Glu Ser 
65                  70                  75                  80  


Gly Trp Tyr Trp Gly Ser Ile Xaa Ala Ser Glu Ala Arg Gln His Leu 
                85                  90                  95      


Gln Lys Met Pro Glu Gly Xaa Phe Leu Val Arg Asp Ser Xaa His Pro 
            100                 105                 110         


Ser Tyr Leu Phe Xaa Leu Ser Val Lys Xaa Xaa Arg Gly Pro Xaa Asn 
        115                 120                 125             


Val Arg Ile Glu Tyr Ala Asp Ser Ser Phe Arg Leu Asp Ser Asn Cys 
    130                 135                 140                 


Leu Ser Arg Pro Arg Ile Leu Ala Phe Pro Asp Val Val Ser Leu Val 
145                 150                 155                 160 


Gln His Tyr Val Ala Ser Cys Xaa Ala Asp Xaa Arg Ser Asp Ser Pro 
                165                 170                 175     


Asp Pro Ala Pro Xaa Pro Ala Leu Pro Met Pro Lys Glu Asp Ala Pro 
            180                 185                 190         


Ser Asp Pro Ala Leu Pro Ala Pro Pro Pro Ala Xaa Ala Val His Leu 
        195                 200                 205             


Lys Leu Val Gln Pro Phe Val Arg Arg Ser Ser Ala Arg Ser Leu Gln 
    210                 215                 220                 


His Leu Cys Arg Leu Val Ile Asn Arg Leu Val Ala Asp Val Asp Cys 
225                 230                 235                 240 


Leu Pro Leu Pro Arg Arg Met Ala Asp Tyr Leu Arg Gln Tyr Pro Phe 
                245                 250                 255     


Gln Leu 
        


<210> 6255
<211> 275
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<400> 6255
Met Tyr Leu Glu His Xaa Ser His Cys Pro His His Asp Asp Asp Xaa 
1               5                   10                  15      


Ala Met Asp Xaa Pro Leu Pro Arg Pro Arg Pro Leu Leu Ala Val Glu 
            20                  25                  30          


Arg Xaa Gly Gln Arg Pro Leu Trp Ala Pro Ser Leu Glu Leu Pro Lys 
        35                  40                  45              


Pro Val Met Gln Pro Leu Pro Ala Gly Ala Phe Leu Glu Glu Val Ala 
    50                  55                  60                  


Glu Gly Xaa Pro Ala Gln Xaa Glu Ser Glu Pro Lys Val Leu Asp Pro 
65                  70                  75                  80  


Glu Glu Asp Leu Leu Cys Ile Ala Lys Xaa Phe Ser Tyr Leu Arg Glu 
                85                  90                  95      


Ser Gly Trp Tyr Trp Gly Ser Ile Xaa Ala Ser Glu Ala Arg Gln His 
            100                 105                 110         


Leu Gln Lys Met Pro Glu Gly Xaa Phe Leu Val Arg Asp Ser Xaa His 
        115                 120                 125             


Pro Ser Tyr Leu Phe Xaa Leu Ser Val Lys Xaa Xaa Arg Gly Pro Xaa 
    130                 135                 140                 


Asn Val Arg Ile Glu Tyr Ala Asp Ser Ser Phe Arg Leu Asp Ser Asn 
145                 150                 155                 160 


Cys Leu Ser Arg Pro Arg Ile Leu Ala Phe Pro Asp Val Val Ser Leu 
                165                 170                 175     


Val Gln His Tyr Val Ala Ser Cys Xaa Ala Asp Xaa Arg Ser Asp Ser 
            180                 185                 190         


Pro Asp Pro Ala Pro Xaa Pro Ala Leu Pro Met Pro Lys Glu Asp Ala 
        195                 200                 205             


Pro Ser Asp Pro Ala Leu Pro Ala Pro Pro Pro Ala Xaa Ala Val His 
    210                 215                 220                 


Leu Lys Leu Val Gln Pro Phe Val Arg Arg Ser Ser Ala Arg Ser Leu 
225                 230                 235                 240 


Gln His Leu Cys Arg Leu Val Ile Asn Arg Leu Val Ala Asp Val Asp 
                245                 250                 255     


Cys Leu Pro Leu Pro Arg Arg Met Ala Asp Tyr Leu Arg Gln Tyr Pro 
            260                 265                 270         


Phe Gln Leu 
        275 


<210> 6256
<211> 109
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<400> 6256
Ile Ala Glu Leu Gln Glu Leu Gln Pro Ser Ala Lys Asp Phe Glu Val 
1               5                   10                  15      


Arg Ser Leu Val Gly Cys Gly His Phe Ala Glu Val Gln Val Val Arg 
            20                  25                  30          


Glu Lys Ala Xaa Gly Asp Ile Tyr Ala Met Lys Val Met Lys Lys Lys 
        35                  40                  45              


Ala Leu Leu Ala Gln Glu Gln Val Ser Phe Phe Glu Glu Glu Arg Asn 
    50                  55                  60                  


Ile Leu Ser Arg Ser Xaa Ser Pro Trp Ile Pro Gln Leu Gln Tyr Ala 
65                  70                  75                  80  


Phe Gln Asp Lys Asn His Leu Tyr Leu Val Leu Tyr Ser His Glu Lys 
                85                  90                  95      


Val Lys Met Glu Gly Xaa Ile Ser Gln Gln Xaa Lys Leu 
            100                 105                 


<210> 6257
<211> 482
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<400> 6257
Met Leu Lys Phe Lys Tyr Gly Ala Arg Asn Pro Leu Asp Ala Gly Ala 
1               5                   10                  15      


Ala Glu Pro Ile Ala Ser Arg Ala Ser Arg Leu Asn Leu Phe Phe Gln 
            20                  25                  30          


Gly Lys Pro Pro Phe Met Xaa Gln Gln Gln Met Ser Pro Leu Ser Arg 
        35                  40                  45              


Glu Gly Ile Leu Asp Ala Leu Phe Val Leu Phe Glu Glu Cys Ser Gln 
    50                  55                  60                  


Pro Ala Leu Met Lys Ile Lys His Val Ser Asn Phe Val Arg Lys Tyr 
65                  70                  75                  80  


Ser Asp Xaa Ile Ala Glu Leu Gln Glu Leu Gln Pro Ser Ala Lys Asp 
                85                  90                  95      


Phe Glu Val Arg Ser Leu Val Gly Cys Gly His Phe Ala Glu Val Gln 
            100                 105                 110         


Val Val Arg Glu Lys Ala Xaa Gly Asp Ile Tyr Ala Met Lys Val Met 
        115                 120                 125             


Lys Lys Lys Ala Leu Leu Ala Gln Glu Gln Val Ser Phe Phe Glu Glu 
    130                 135                 140                 


Glu Arg Asn Ile Leu Ser Arg Ser Xaa Ser Pro Trp Ile Pro Gln Leu 
145                 150                 155                 160 


Gln Tyr Ala Phe Gln Asp Lys Asn His Leu Tyr Leu Val Met Glu Tyr 
                165                 170                 175     


Gln Pro Gly Gly Asp Leu Leu Ser Leu Leu Asn Arg Tyr Glu Asp Gln 
            180                 185                 190         


Leu Asp Glu Asn Leu Ile Gln Phe Tyr Leu Ala Glu Leu Ile Leu Ala 
        195                 200                 205             


Val His Ser Val His Leu Met Gly Tyr Val His Arg Asp Ile Lys Pro 
    210                 215                 220                 


Glu Asn Ile Leu Val Asp Arg Xaa Gly His Ile Lys Leu Val Asp Phe 
225                 230                 235                 240 


Gly Ser Ala Ala Lys Met Asn Ser Asn Lys Met Val Asn Ala Lys Leu 
                245                 250                 255     


Pro Ile Gly Xaa Pro Asp Tyr Met Ala Pro Glu Val Leu Xaa Val Met 
            260                 265                 270         


Asn Gly Asp Gly Lys Gly Xaa Tyr Gly Leu Asp Cys Asp Trp Trp Ser 
        275                 280                 285             


Val Gly Val Ile Ala Tyr Glu Met Ile Tyr Gly Arg Ser Pro Phe Ala 
    290                 295                 300                 


Glu Gly Xaa Ser Ala Arg Xaa Phe Asn Asn Ile Met Asn Phe Gln Arg 
305                 310                 315                 320 


Phe Leu Lys Phe Pro Asp Asp Pro Lys Val Ser Ser Asp Phe Leu Asp 
                325                 330                 335     


Leu Ile Gln Ser Leu Leu Cys Gly Gln Lys Glu Arg Leu Lys Phe Glu 
            340                 345                 350         


Gly Leu Cys Cys His Pro Phe Phe Ser Lys Ile Asp Trp Asn Asn Ile 
        355                 360                 365             


Arg Asn Ser Pro Pro Pro Phe Val Pro Xaa Leu Lys Ser Asp Asp Asp 
    370                 375                 380                 


Xaa Ser Asn Phe Asp Glu Pro Glu Lys Asn Ser Trp Val Ser Ser Ser 
385                 390                 395                 400 


Pro Cys Gln Leu Ser Pro Ser Gly Phe Ser Gly Glu Glu Leu Pro Phe 
                405                 410                 415     


Val Gly Phe Ser Tyr Ser Lys Ala Leu Gly Ile Leu Gly Arg Ser Glu 
            420                 425                 430         


Ser Val Val Ser Gly Leu Asp Ser Pro Ala Lys Xaa Ser Ser Met Glu 
        435                 440                 445             


Lys Lys Leu Leu Ile Lys Ser Lys Glu Leu Gln Asp Ser Gln Asp Lys 
    450                 455                 460                 


Cys His Lys Met Glu Gln Glu Met Xaa Arg Leu His Arg Arg Val Ser 
465                 470                 475                 480 


Gly Gly 
        


<210> 6258
<211> 2027
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1017)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1083)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1189)..(1189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1252)..(1252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1282)..(1282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1299)..(1299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1306)..(1306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1374)..(1374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1382)..(1382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1405)..(1405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1410)..(1410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1419)..(1419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1422)..(1422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1437)..(1437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1516)..(1516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1533)..(1534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1540)..(1540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1556)..(1556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1597)..(1597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1624)..(1624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1730)..(1730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1740)..(1740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1748)..(1748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1760)..(1760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1820)..(1820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1842)..(1842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1860)..(1860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1908)..(1908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1916)..(1916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1928)..(1928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1934)..(1934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1955)..(1955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1964)..(1964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1988)..(1988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2013)..(2013)
<223> Selenocysteine

<400> 6258
Met Leu Lys Phe Lys Tyr Gly Ala Arg Asn Pro Leu Asp Ala Gly Ala 
1               5                   10                  15      


Ala Glu Pro Ile Ala Ser Arg Ala Ser Arg Leu Asn Leu Phe Phe Gln 
            20                  25                  30          


Gly Lys Pro Pro Phe Met Xaa Gln Gln Gln Met Ser Pro Leu Ser Arg 
        35                  40                  45              


Glu Gly Ile Leu Asp Ala Leu Phe Val Leu Phe Glu Glu Cys Ser Gln 
    50                  55                  60                  


Pro Ala Leu Met Lys Ile Lys His Val Ser Asn Phe Val Arg Lys Tyr 
65                  70                  75                  80  


Ser Asp Xaa Ile Ala Glu Leu Gln Glu Leu Gln Pro Ser Ala Lys Asp 
                85                  90                  95      


Phe Glu Val Arg Ser Leu Val Gly Cys Gly His Phe Ala Glu Val Gln 
            100                 105                 110         


Val Val Arg Glu Lys Ala Xaa Gly Asp Ile Tyr Ala Met Lys Val Met 
        115                 120                 125             


Lys Lys Lys Ala Leu Leu Ala Gln Glu Gln Val Ser Phe Phe Glu Glu 
    130                 135                 140                 


Glu Arg Asn Ile Leu Ser Arg Ser Xaa Ser Pro Trp Ile Pro Gln Leu 
145                 150                 155                 160 


Gln Tyr Ala Phe Gln Asp Lys Asn His Leu Tyr Leu Val Met Glu Tyr 
                165                 170                 175     


Gln Pro Gly Gly Asp Leu Leu Ser Leu Leu Asn Arg Tyr Glu Asp Gln 
            180                 185                 190         


Leu Asp Glu Asn Leu Ile Gln Phe Tyr Leu Ala Glu Leu Ile Leu Ala 
        195                 200                 205             


Val His Ser Val His Leu Met Gly Tyr Val His Arg Asp Ile Lys Pro 
    210                 215                 220                 


Glu Asn Ile Leu Val Asp Arg Xaa Gly His Ile Lys Leu Val Asp Phe 
225                 230                 235                 240 


Gly Ser Ala Ala Lys Met Asn Ser Asn Lys Met Val Asn Ala Lys Leu 
                245                 250                 255     


Pro Ile Gly Xaa Pro Asp Tyr Met Ala Pro Glu Val Leu Xaa Val Met 
            260                 265                 270         


Asn Gly Asp Gly Lys Gly Xaa Tyr Gly Leu Asp Cys Asp Trp Trp Ser 
        275                 280                 285             


Val Gly Val Ile Ala Tyr Glu Met Ile Tyr Gly Arg Ser Pro Phe Ala 
    290                 295                 300                 


Glu Gly Xaa Ser Ala Arg Xaa Phe Asn Asn Ile Met Asn Phe Gln Arg 
305                 310                 315                 320 


Phe Leu Lys Phe Pro Asp Asp Pro Lys Val Ser Ser Asp Phe Leu Asp 
                325                 330                 335     


Leu Ile Gln Ser Leu Leu Cys Gly Gln Lys Glu Arg Leu Lys Phe Glu 
            340                 345                 350         


Gly Leu Cys Cys His Pro Phe Phe Ser Lys Ile Asp Trp Asn Asn Ile 
        355                 360                 365             


Arg Asn Ser Pro Pro Pro Phe Val Pro Xaa Leu Lys Ser Asp Asp Asp 
    370                 375                 380                 


Xaa Ser Asn Phe Asp Glu Pro Glu Lys Asn Ser Trp Val Ser Ser Ser 
385                 390                 395                 400 


Pro Cys Gln Leu Ser Pro Ser Gly Phe Ser Gly Glu Glu Leu Pro Phe 
                405                 410                 415     


Val Gly Phe Ser Tyr Ser Lys Ala Leu Gly Ile Leu Gly Arg Ser Glu 
            420                 425                 430         


Ser Val Val Ser Gly Leu Asp Ser Pro Ala Lys Xaa Ser Ser Met Glu 
        435                 440                 445             


Lys Lys Leu Leu Ile Lys Ser Lys Glu Leu Gln Asp Ser Gln Asp Lys 
    450                 455                 460                 


Cys His Lys Met Glu Gln Glu Met Xaa Arg Leu His Arg Arg Val Ser 
465                 470                 475                 480 


Glu Val Glu Ala Val Leu Ser Gln Lys Glu Val Glu Leu Lys Ala Ser 
                485                 490                 495     


Glu Xaa Gln Arg Ser Leu Leu Glu Gln Asp Leu Ala Xaa Tyr Ile Xaa 
            500                 505                 510         


Glu Cys Ser Ser Leu Lys Arg Ser Leu Glu Gln Ala Arg Met Glu Val 
        515                 520                 525             


Ser Gln Glu Asp Asp Lys Ala Leu Gln Leu Leu His Asp Ile Arg Glu 
    530                 535                 540                 


Gln Ser Arg Lys Leu Gln Glu Ile Lys Glu Gln Glu Tyr Gln Ala Gln 
545                 550                 555                 560 


Val Glu Glu Met Arg Leu Met Met Asn Gln Leu Glu Glu Asp Leu Val 
                565                 570                 575     


Ser Ala Arg Arg Arg Ser Asp Leu Tyr Glu Ser Glu Leu Arg Glu Ser 
            580                 585                 590         


Arg Leu Ala Ala Glu Glu Phe Lys Arg Lys Ala Xaa Glu Cys Gln His 
        595                 600                 605             


Lys Leu Leu Lys Ala Lys Asp Gln Gly Lys Pro Glu Val Gly Glu Tyr 
    610                 615                 620                 


Ala Lys Leu Glu Lys Ile Asn Ala Glu Gln Gln Leu Lys Ile Gln Glu 
625                 630                 635                 640 


Leu Gln Glu Lys Leu Glu Lys Ala Val Lys Ala Ser Xaa Glu Ala Xaa 
                645                 650                 655     


Glu Leu Leu Gln Asn Ile Arg Gln Ala Lys Glu Arg Ala Glu Arg Glu 
            660                 665                 670         


Leu Glu Lys Leu Gln Asn Arg Glu Asp Ser Ser Glu Gly Ile Arg Lys 
        675                 680                 685             


Lys Leu Val Glu Ala Glu Glu Leu Glu Glu Lys His Arg Glu Ala Gln 
    690                 695                 700                 


Val Ser Ala Gln His Leu Glu Val His Leu Lys Gln Lys Glu Gln His 
705                 710                 715                 720 


Tyr Glu Glu Lys Ile Lys Val Leu Asp Asn Gln Ile Lys Lys Asp Leu 
                725                 730                 735     


Ala Asp Lys Glu Xaa Leu Glu Asn Met Met Gln Arg His Glu Glu Glu 
            740                 745                 750         


Ala His Glu Lys Gly Lys Ile Leu Ser Glu Gln Lys Ala Met Ile Asn 
        755                 760                 765             


Ala Met Asp Ser Lys Ile Arg Ser Leu Glu Gln Arg Ile Val Glu Leu 
    770                 775                 780                 


Ser Glu Ala Asn Lys Leu Ala Ala Asn Ser Ser Leu Phe Xaa Gln Arg 
785                 790                 795                 800 


Asn Met Lys Ala Gln Glu Glu Met Ile Ser Glu Leu Arg Gln Gln Lys 
                805                 810                 815     


Phe Tyr Leu Glu Xaa Gln Ala Gly Lys Leu Glu Ala Gln Asn Arg Lys 
            820                 825                 830         


Leu Glu Glu Gln Leu Glu Lys Ile Ser His Gln Asp His Ser Asp Lys 
        835                 840                 845             


Asn Arg Leu Leu Glu Leu Glu Xaa Arg Leu Arg Glu Val Ser Leu Glu 
    850                 855                 860                 


His Glu Glu Gln Lys Leu Glu Leu Lys Arg Gln Leu Xaa Glu Leu Gln 
865                 870                 875                 880 


Leu Ser Leu Gln Glu Arg Glu Ser Gln Leu Xaa Ala Leu Gln Ala Ala 
                885                 890                 895     


Arg Ala Ala Leu Glu Ser Gln Leu Arg Gln Ala Lys Xaa Glu Leu Glu 
            900                 905                 910         


Glu Xaa Xaa Ala Glu Ala Glu Glu Glu Ile Gln Ala Leu Xaa Ala His 
        915                 920                 925             


Arg Asp Glu Ile Gln Arg Lys Phe Asp Ala Leu Arg Asn Ser Cys Xaa 
    930                 935                 940                 


Val Ile Xaa Asp Leu Glu Glu Gln Leu Asn Gln Leu Xaa Glu Asp Asn 
945                 950                 955                 960 


Ala Glu Leu Asn Asn Gln Asn Phe Tyr Leu Ser Lys Gln Leu Asp Glu 
                965                 970                 975     


Ala Ser Gly Ala Asn Asp Glu Ile Val Gln Leu Arg Ser Glu Val Asp 
            980                 985                 990         


His Leu Arg Arg Glu Ile Xaa Glu  Arg Glu Met Gln Leu  Xaa Ser Gln 
        995                 1000                 1005             


Lys Gln  Xaa Met Glu Ala Leu  Lys Xaa Xaa Cys Xaa  Met Leu Glu 
    1010                 1015                 1020             


Glu Gln  Val Met Asp Leu Glu  Ala Leu Asn Asp Glu  Leu Leu Glu 
    1025                 1030                 1035             


Lys Glu  Arg Gln Trp Glu Ala  Trp Arg Ser Val Leu  Gly Asp Glu 
    1040                 1045                 1050             


Lys Ser  Gln Phe Glu Cys Arg  Val Arg Glu Leu Gln  Arg Met Leu 
    1055                 1060                 1065             


Asp Xaa  Glu Lys Gln Ser Arg  Ala Arg Ala Asp Gln  Arg Ile Xaa 
    1070                 1075                 1080             


Glu Ser  Arg Gln Val Val Glu  Leu Ala Val Lys Glu  His Lys Ala 
    1085                 1090                 1095             


Glu Ile  Leu Ala Leu Gln Gln  Ala Leu Lys Glu Gln  Lys Leu Lys 
    1100                 1105                 1110             


Ala Glu  Ser Leu Ser Asp Lys  Leu Asn Asp Leu Glu  Lys Lys His 
    1115                 1120                 1125             


Ala Met  Leu Glu Met Asn Ala  Arg Ser Leu Gln Gln  Lys Leu Glu 
    1130                 1135                 1140             


Xaa Glu  Arg Glu Leu Lys Gln  Arg Leu Leu Glu Glu  Gln Ala Lys 
    1145                 1150                 1155             


Leu Gln  Gln Gln Met Asp Leu  Gln Lys Asn His Ile  Phe Arg Leu 
    1160                 1165                 1170             


Xaa Gln  Gly Leu Gln Glu Ala  Leu Asp Arg Ala Asp  Leu Leu Lys 
    1175                 1180                 1185             


Xaa Glu  Arg Ser Asp Leu Glu  Tyr Gln Leu Glu Asn  Ile Gln Val 
    1190                 1195                 1200             


Leu Tyr  Ser His Glu Lys Val  Lys Met Glu Gly Xaa  Ile Ser Gln 
    1205                 1210                 1215             


Gln Xaa  Lys Leu Ile Asp Phe  Leu Gln Ala Lys Met  Asp Gln Pro 
    1220                 1225                 1230             


Ala Lys  Lys Lys Lys Gly Leu  Phe Ser Arg Arg Lys  Glu Asp Pro 
    1235                 1240                 1245             


Ala Leu  Pro Xaa Gln Val Pro  Leu Gln Tyr Asn Glu  Leu Lys Leu 
    1250                 1255                 1260             


Ala Leu  Glu Lys Glu Lys Ala  Arg Cys Ala Glu Leu  Glu Glu Ala 
    1265                 1270                 1275             


Leu Gln  Lys Xaa Arg Ile Glu  Leu Arg Ser Ala Arg  Glu Glu Ala 
    1280                 1285                 1290             


Ala His  Arg Lys Ala Xaa Asp  His Pro His Pro Ser  Xaa Pro Ala 
    1295                 1300                 1305             


Xaa Ala  Arg Gln Gln Ile Ala  Met Ser Ala Ile Val  Arg Ser Pro 
    1310                 1315                 1320             


Glu His  Gln Pro Ser Ala Met  Ser Leu Leu Ala Pro  Pro Ser Ser 
    1325                 1330                 1335             


Arg Arg  Lys Glu Ser Ser Xaa  Pro Glu Glu Phe Ser  Arg Arg Leu 
    1340                 1345                 1350             


Lys Glu  Arg Met His His Asn  Ile Pro His Arg Phe  Asn Val Gly 
    1355                 1360                 1365             


Leu Asn  Met Arg Ala Xaa Lys  Cys Ala Val Cys Leu  Asp Xaa Val 
    1370                 1375                 1380             


His Phe  Gly Arg Gln Ala Ser  Lys Cys Leu Glu Cys  Gln Val Met 
    1385                 1390                 1395             


Cys His  Pro Lys Cys Ser Xaa  Cys Leu Pro Ala Xaa  Cys Gly Leu 
    1400                 1405                 1410             


Pro Ala  Glu Tyr Ala Xaa His  Phe Xaa Glu Ala Phe  Cys Arg Asp 
    1415                 1420                 1425             


Lys Met  Asn Ser Pro Gly Leu  Gln Xaa Lys Glu Pro  Ser Ser Ser 
    1430                 1435                 1440             


Leu His  Leu Glu Gly Trp Met  Lys Val Pro Arg Asn  Asn Lys Arg 
    1445                 1450                 1455             


Gly Gln  Gln Gly Trp Asp Arg  Lys Tyr Ile Val Leu  Glu Gly Ser 
    1460                 1465                 1470             


Lys Val  Leu Ile Tyr Asp Asn  Glu Ala Arg Glu Ala  Gly Gln Arg 
    1475                 1480                 1485             


Pro Val  Glu Glu Phe Glu Leu  Cys Leu Pro Asp Gly  Asp Val Ser 
    1490                 1495                 1500             


Ile His  Gly Ala Val Gly Ala  Ser Glu Leu Ala Asn  Xaa Ala Lys 
    1505                 1510                 1515             


Ala Asp  Val Pro Tyr Ile Leu  Lys Met Glu Ser His  Pro His Xaa 
    1520                 1525                 1530             


Xaa Cys  Trp Pro Gly Arg Xaa  Leu Tyr Leu Leu Ala  Pro Ser Phe 
    1535                 1540                 1545             


Pro Asp  Lys Gln Arg Trp Val  Xaa Ala Leu Glu Ser  Val Val Ala 
    1550                 1555                 1560             


Gly Gly  Arg Val Ser Arg Glu  Lys Ala Glu Ala Asp  Ala Lys Leu 
    1565                 1570                 1575             


Leu Gly  Asn Ser Leu Leu Lys  Leu Glu Gly Asp Asp  Arg Leu Asp 
    1580                 1585                 1590             


Met Asn  Cys Xaa Leu Pro Phe  Ser Asp Gln Val Val  Leu Val Gly 
    1595                 1600                 1605             


Xaa Glu  Glu Gly Leu Tyr Ala  Leu Asn Val Leu Lys  Asn Ser Leu 
    1610                 1615                 1620             


Xaa His  Val Pro Gly Ile Gly  Ala Val Phe Gln Ile  Tyr Ile Ile 
    1625                 1630                 1635             


Lys Asp  Leu Glu Lys Leu Leu  Met Ile Ala Gly Glu  Glu Arg Ala 
    1640                 1645                 1650             


Leu Cys  Leu Val Asp Val Lys  Lys Val Lys Gln Ser  Leu Ala Gln 
    1655                 1660                 1665             


Ser His  Leu Pro Ala Gln Pro  Asp Ile Ser Pro Asn  Ile Phe Glu 
    1670                 1675                 1680             


Ala Val  Lys Gly Cys His Leu  Phe Gly Ala Gly Lys  Ile Glu Asn 
    1685                 1690                 1695             


Gly Leu  Cys Ile Cys Ala Ala  Met Pro Ser Lys Val  Val Ile Leu 
    1700                 1705                 1710             


Arg Tyr  Asn Glu Asn Leu Ser  Lys Tyr Cys Ile Arg  Lys Glu Ile 
    1715                 1720                 1725             


Glu Xaa  Ser Glu Pro Cys Ser  Cys Ile His Phe Xaa  Asn Tyr Ser 
    1730                 1735                 1740             


Ile Leu  Ile Gly Xaa Asn Lys  Phe Tyr Glu Ile Asp  Met Lys Gln 
    1745                 1750                 1755             


Tyr Xaa  Leu Glu Glu Phe Leu  Asp Lys Asn Asp His  Ser Leu Ala 
    1760                 1765                 1770             


Pro Ala  Val Phe Ala Ala Ser  Ser Asn Ser Phe Pro  Val Ser Ile 
    1775                 1780                 1785             


Val Gln  Val Asn Ser Ala Gly  Gln Arg Glu Glu Tyr  Leu Leu Cys 
    1790                 1795                 1800             


Phe His  Glu Phe Gly Val Phe  Val Asp Ser Tyr Gly  Arg Arg Ser 
    1805                 1810                 1815             


Arg Xaa  Asp Asp Leu Lys Trp  Ser Arg Leu Pro Leu  Ala Phe Ala 
    1820                 1825                 1830             


Tyr Arg  Glu Pro Tyr Leu Phe  Val Xaa His Phe Asn  Ser Leu Glu 
    1835                 1840                 1845             


Val Ile  Glu Ile Gln Ala Arg  Ser Ser Ala Gly Xaa  Pro Ala Arg 
    1850                 1855                 1860             


Ala Tyr  Leu Asp Ile Pro Asn  Pro Arg Tyr Leu Gly  Pro Ala Ile 
    1865                 1870                 1875             


Ser Ser  Gly Ala Ile Tyr Leu  Ala Ser Ser Tyr Gln  Asp Lys Leu 
    1880                 1885                 1890             


Arg Val  Ile Cys Cys Lys Gly  Asn Leu Val Lys Glu  Ser Gly Xaa 
    1895                 1900                 1905             


Glu His  His Arg Gly Pro Ser  Xaa Ser Arg Ser Ser  Pro Asn Lys 
    1910                 1915                 1920             


Arg Gly  Pro Pro Xaa Tyr Asn  Glu His Ile Xaa Lys  Arg Val Ala 
    1925                 1930                 1935             


Ser Ser  Pro Ala Pro Pro Glu  Gly Pro Ser His Pro  Arg Glu Pro 
    1940                 1945                 1950             


Ser Xaa  Pro His Arg Tyr Arg  Glu Gly Arg Xaa Glu  Leu Arg Arg 
    1955                 1960                 1965             


Asp Lys  Ser Pro Gly Arg Pro  Leu Glu Arg Glu Lys  Ser Pro Gly 
    1970                 1975                 1980             


Arg Met  Leu Ser Xaa Arg Arg  Glu Arg Ser Pro Gly  Arg Leu Phe 
    1985                 1990                 1995             


Glu Asp  Ser Ser Arg Gly Arg  Leu Pro Ala Gly Ala  Val Arg Xaa 
    2000                 2005                 2010             


Pro Leu  Ser Gln Val Asn Lys  Val Trp Asp Gln Ser  Ser Val 
    2015                 2020                 2025         


<210> 6259
<211> 2069
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1262)..(1262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1294)..(1294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1324)..(1324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1341)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1387)..(1387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1416)..(1416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1424)..(1424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1447)..(1447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1452)..(1452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1461)..(1461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1464)..(1464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1479)..(1479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1558)..(1558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1575)..(1576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1598)..(1598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1639)..(1639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1651)..(1651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1666)..(1666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1772)..(1772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1782)..(1782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1802)..(1802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1862)..(1862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1884)..(1884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1902)..(1902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1950)..(1950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1958)..(1958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1970)..(1970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1976)..(1976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1997)..(1997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2006)..(2006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2030)..(2030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2055)..(2055)
<223> Selenocysteine

<400> 6259
Met Leu Lys Phe Lys Tyr Gly Ala Arg Asn Pro Leu Asp Ala Gly Ala 
1               5                   10                  15      


Ala Glu Pro Ile Ala Ser Arg Ala Ser Arg Leu Asn Leu Phe Phe Gln 
            20                  25                  30          


Gly Lys Pro Pro Phe Met Xaa Gln Gln Gln Met Ser Pro Leu Ser Arg 
        35                  40                  45              


Glu Gly Ile Leu Asp Ala Leu Phe Val Leu Phe Glu Glu Cys Ser Gln 
    50                  55                  60                  


Pro Ala Leu Met Lys Ile Lys His Val Ser Asn Phe Val Arg Lys Tyr 
65                  70                  75                  80  


Ser Asp Xaa Ile Ala Glu Leu Gln Glu Leu Gln Pro Ser Ala Lys Asp 
                85                  90                  95      


Phe Glu Val Arg Ser Leu Val Gly Cys Gly His Phe Ala Glu Val Gln 
            100                 105                 110         


Val Val Arg Glu Lys Ala Xaa Gly Asp Ile Tyr Ala Met Lys Val Met 
        115                 120                 125             


Lys Lys Lys Ala Leu Leu Ala Gln Glu Gln Val Ser Phe Phe Glu Glu 
    130                 135                 140                 


Glu Arg Asn Ile Leu Ser Arg Ser Xaa Ser Pro Trp Ile Pro Gln Leu 
145                 150                 155                 160 


Gln Tyr Ala Phe Gln Asp Lys Asn His Leu Tyr Leu Val Met Glu Tyr 
                165                 170                 175     


Gln Pro Gly Gly Asp Leu Leu Ser Leu Leu Asn Arg Tyr Glu Asp Gln 
            180                 185                 190         


Leu Asp Glu Asn Leu Ile Gln Phe Tyr Leu Ala Glu Leu Ile Leu Ala 
        195                 200                 205             


Val His Ser Val His Leu Met Gly Tyr Val His Arg Asp Ile Lys Pro 
    210                 215                 220                 


Glu Asn Ile Leu Val Asp Arg Xaa Gly His Ile Lys Leu Val Asp Phe 
225                 230                 235                 240 


Gly Ser Ala Ala Lys Met Asn Ser Asn Lys Met Val Asn Ala Lys Leu 
                245                 250                 255     


Pro Ile Gly Xaa Pro Asp Tyr Met Ala Pro Glu Val Leu Xaa Val Met 
            260                 265                 270         


Asn Gly Asp Gly Lys Gly Xaa Tyr Gly Leu Asp Cys Asp Trp Trp Ser 
        275                 280                 285             


Val Gly Val Ile Ala Tyr Glu Met Ile Tyr Gly Arg Ser Pro Phe Ala 
    290                 295                 300                 


Glu Gly Xaa Ser Ala Arg Xaa Phe Asn Asn Ile Met Asn Phe Gln Arg 
305                 310                 315                 320 


Phe Leu Lys Phe Pro Asp Asp Pro Lys Val Ser Ser Asp Phe Leu Asp 
                325                 330                 335     


Leu Ile Gln Ser Leu Leu Cys Gly Gln Lys Glu Arg Leu Lys Phe Glu 
            340                 345                 350         


Gly Leu Cys Cys His Pro Phe Phe Ser Lys Ile Asp Trp Asn Asn Ile 
        355                 360                 365             


Arg Asn Ser Pro Pro Pro Phe Val Pro Xaa Leu Lys Ser Asp Asp Asp 
    370                 375                 380                 


Xaa Ser Asn Phe Asp Glu Pro Glu Lys Asn Ser Trp Val Ser Ser Ser 
385                 390                 395                 400 


Pro Cys Gln Leu Ser Pro Ser Gly Phe Ser Gly Glu Glu Leu Pro Phe 
                405                 410                 415     


Val Gly Phe Ser Tyr Ser Lys Ala Leu Gly Ile Leu Gly Arg Ser Glu 
            420                 425                 430         


Ser Val Val Ser Gly Leu Asp Ser Pro Ala Lys Xaa Ser Ser Met Glu 
        435                 440                 445             


Lys Lys Leu Leu Ile Lys Ser Lys Glu Leu Gln Asp Ser Gln Asp Lys 
    450                 455                 460                 


Cys His Lys Met Glu Gln Glu Met Xaa Arg Leu His Arg Arg Val Ser 
465                 470                 475                 480 


Glu Val Glu Ala Val Leu Ser Gln Lys Glu Val Glu Leu Lys Ala Ser 
                485                 490                 495     


Glu Xaa Gln Arg Ser Leu Leu Glu Gln Asp Leu Ala Xaa Tyr Ile Xaa 
            500                 505                 510         


Glu Cys Ser Ser Leu Lys Arg Ser Leu Glu Gln Ala Arg Met Glu Val 
        515                 520                 525             


Ser Gln Glu Asp Asp Lys Ala Leu Gln Leu Leu His Asp Ile Arg Glu 
    530                 535                 540                 


Gln Ser Arg Lys Leu Gln Glu Ile Lys Glu Gln Glu Tyr Gln Ala Gln 
545                 550                 555                 560 


Val Glu Glu Met Arg Leu Met Met Asn Gln Leu Glu Glu Asp Leu Val 
                565                 570                 575     


Ser Ala Arg Arg Arg Ser Asp Leu Tyr Glu Ser Glu Leu Arg Glu Ser 
            580                 585                 590         


Arg Leu Ala Ala Glu Glu Phe Lys Arg Lys Ala Xaa Glu Cys Gln His 
        595                 600                 605             


Lys Leu Leu Lys Ala Lys Asp Gln Gly Lys Pro Glu Val Gly Glu Tyr 
    610                 615                 620                 


Ala Lys Leu Glu Lys Ile Asn Ala Glu Gln Gln Leu Lys Ile Gln Glu 
625                 630                 635                 640 


Leu Gln Glu Lys Leu Glu Lys Ala Val Lys Ala Ser Xaa Glu Ala Xaa 
                645                 650                 655     


Glu Leu Leu Gln Asn Ile Arg Gln Ala Lys Glu Arg Ala Glu Arg Glu 
            660                 665                 670         


Leu Glu Lys Leu Gln Asn Arg Glu Asp Ser Ser Glu Gly Ile Arg Lys 
        675                 680                 685             


Lys Leu Val Glu Ala Glu Glu Arg Arg His Ser Leu Glu Asn Lys Val 
    690                 695                 700                 


Lys Arg Leu Glu Xaa Met Glu Arg Arg Glu Asn Arg Leu Lys Asp Asp 
705                 710                 715                 720 


Ile Gln Xaa Lys Ser Gln Gln Ile Gln Gln Met Ala Asp Lys Ile Leu 
                725                 730                 735     


Glu Leu Glu Glu Lys His Arg Glu Ala Gln Val Ser Ala Gln His Leu 
            740                 745                 750         


Glu Val His Leu Lys Gln Lys Glu Gln His Tyr Glu Glu Lys Ile Lys 
        755                 760                 765             


Val Leu Asp Asn Gln Ile Lys Lys Asp Leu Ala Asp Lys Glu Xaa Leu 
    770                 775                 780                 


Glu Asn Met Met Gln Arg His Glu Glu Glu Ala His Glu Lys Gly Lys 
785                 790                 795                 800 


Ile Leu Ser Glu Gln Lys Ala Met Ile Asn Ala Met Asp Ser Lys Ile 
                805                 810                 815     


Arg Ser Leu Glu Gln Arg Ile Val Glu Leu Ser Glu Ala Asn Lys Leu 
            820                 825                 830         


Ala Ala Asn Ser Ser Leu Phe Xaa Gln Arg Asn Met Lys Ala Gln Glu 
        835                 840                 845             


Glu Met Ile Ser Glu Leu Arg Gln Gln Lys Phe Tyr Leu Glu Xaa Gln 
    850                 855                 860                 


Ala Gly Lys Leu Glu Ala Gln Asn Arg Lys Leu Glu Glu Gln Leu Glu 
865                 870                 875                 880 


Lys Ile Ser His Gln Asp His Ser Asp Lys Asn Arg Leu Leu Glu Leu 
                885                 890                 895     


Glu Xaa Arg Leu Arg Glu Val Ser Leu Glu His Glu Glu Gln Lys Leu 
            900                 905                 910         


Glu Leu Lys Arg Gln Leu Xaa Glu Leu Gln Leu Ser Leu Gln Glu Arg 
        915                 920                 925             


Glu Ser Gln Leu Xaa Ala Leu Gln Ala Ala Arg Ala Ala Leu Glu Ser 
    930                 935                 940                 


Gln Leu Arg Gln Ala Lys Xaa Glu Leu Glu Glu Xaa Xaa Ala Glu Ala 
945                 950                 955                 960 


Glu Glu Glu Ile Gln Ala Leu Xaa Ala His Arg Asp Glu Ile Gln Arg 
                965                 970                 975     


Lys Phe Asp Ala Leu Arg Asn Ser Cys Xaa Val Ile Xaa Asp Leu Glu 
            980                 985                 990         


Glu Gln Leu Asn Gln Leu Xaa Glu  Asp Asn Ala Glu Leu  Asn Asn Gln 
        995                 1000                 1005             


Asn Phe  Tyr Leu Ser Lys Gln  Leu Asp Glu Ala Ser  Gly Ala Asn 
    1010                 1015                 1020             


Asp Glu  Ile Val Gln Leu Arg  Ser Glu Val Asp His  Leu Arg Arg 
    1025                 1030                 1035             


Glu Ile  Xaa Glu Arg Glu Met  Gln Leu Xaa Ser Gln  Lys Gln Xaa 
    1040                 1045                 1050             


Met Glu  Ala Leu Lys Xaa Xaa  Cys Xaa Met Leu Glu  Glu Gln Val 
    1055                 1060                 1065             


Met Asp  Leu Glu Ala Leu Asn  Asp Glu Leu Leu Glu  Lys Glu Arg 
    1070                 1075                 1080             


Gln Trp  Glu Ala Trp Arg Ser  Val Leu Gly Asp Glu  Lys Ser Gln 
    1085                 1090                 1095             


Phe Glu  Cys Arg Val Arg Glu  Leu Gln Arg Met Leu  Asp Xaa Glu 
    1100                 1105                 1110             


Lys Gln  Ser Arg Ala Arg Ala  Asp Gln Arg Ile Xaa  Glu Ser Arg 
    1115                 1120                 1125             


Gln Val  Val Glu Leu Ala Val  Lys Glu His Lys Ala  Glu Ile Leu 
    1130                 1135                 1140             


Ala Leu  Gln Gln Ala Leu Lys  Glu Gln Lys Leu Lys  Ala Glu Ser 
    1145                 1150                 1155             


Leu Ser  Asp Lys Leu Asn Asp  Leu Glu Lys Lys His  Ala Met Leu 
    1160                 1165                 1170             


Glu Met  Asn Ala Arg Ser Leu  Gln Gln Lys Leu Glu  Xaa Glu Arg 
    1175                 1180                 1185             


Glu Leu  Lys Gln Arg Leu Leu  Glu Glu Gln Ala Lys  Leu Gln Gln 
    1190                 1195                 1200             


Gln Met  Asp Leu Gln Lys Asn  His Ile Phe Arg Leu  Xaa Gln Gly 
    1205                 1210                 1215             


Leu Gln  Glu Ala Leu Asp Arg  Ala Asp Leu Leu Lys  Xaa Glu Arg 
    1220                 1225                 1230             


Ser Asp  Leu Glu Tyr Gln Leu  Glu Asn Ile Gln Val  Leu Tyr Ser 
    1235                 1240                 1245             


His Glu  Lys Val Lys Met Glu  Gly Xaa Ile Ser Gln  Gln Xaa Lys 
    1250                 1255                 1260             


Leu Ile  Asp Phe Leu Gln Ala  Lys Met Asp Gln Pro  Ala Lys Lys 
    1265                 1270                 1275             


Lys Lys  Gly Leu Phe Ser Arg  Arg Lys Glu Asp Pro  Ala Leu Pro 
    1280                 1285                 1290             


Xaa Gln  Val Pro Leu Gln Tyr  Asn Glu Leu Lys Leu  Ala Leu Glu 
    1295                 1300                 1305             


Lys Glu  Lys Ala Arg Cys Ala  Glu Leu Glu Glu Ala  Leu Gln Lys 
    1310                 1315                 1320             


Xaa Arg  Ile Glu Leu Arg Ser  Ala Arg Glu Glu Ala  Ala His Arg 
    1325                 1330                 1335             


Lys Ala  Xaa Asp His Pro His  Pro Ser Xaa Pro Ala  Xaa Ala Arg 
    1340                 1345                 1350             


Gln Gln  Ile Ala Met Ser Ala  Ile Val Arg Ser Pro  Glu His Gln 
    1355                 1360                 1365             


Pro Ser  Ala Met Ser Leu Leu  Ala Pro Pro Ser Ser  Arg Arg Lys 
    1370                 1375                 1380             


Glu Ser  Ser Xaa Pro Glu Glu  Phe Ser Arg Arg Leu  Lys Glu Arg 
    1385                 1390                 1395             


Met His  His Asn Ile Pro His  Arg Phe Asn Val Gly  Leu Asn Met 
    1400                 1405                 1410             


Arg Ala  Xaa Lys Cys Ala Val  Cys Leu Asp Xaa Val  His Phe Gly 
    1415                 1420                 1425             


Arg Gln  Ala Ser Lys Cys Leu  Glu Cys Gln Val Met  Cys His Pro 
    1430                 1435                 1440             


Lys Cys  Ser Xaa Cys Leu Pro  Ala Xaa Cys Gly Leu  Pro Ala Glu 
    1445                 1450                 1455             


Tyr Ala  Xaa His Phe Xaa Glu  Ala Phe Cys Arg Asp  Lys Met Asn 
    1460                 1465                 1470             


Ser Pro  Gly Leu Gln Xaa Lys  Glu Pro Ser Ser Ser  Leu His Leu 
    1475                 1480                 1485             


Glu Gly  Trp Met Lys Val Pro  Arg Asn Asn Lys Arg  Gly Gln Gln 
    1490                 1495                 1500             


Gly Trp  Asp Arg Lys Tyr Ile  Val Leu Glu Gly Ser  Lys Val Leu 
    1505                 1510                 1515             


Ile Tyr  Asp Asn Glu Ala Arg  Glu Ala Gly Gln Arg  Pro Val Glu 
    1520                 1525                 1530             


Glu Phe  Glu Leu Cys Leu Pro  Asp Gly Asp Val Ser  Ile His Gly 
    1535                 1540                 1545             


Ala Val  Gly Ala Ser Glu Leu  Ala Asn Xaa Ala Lys  Ala Asp Val 
    1550                 1555                 1560             


Pro Tyr  Ile Leu Lys Met Glu  Ser His Pro His Xaa  Xaa Cys Trp 
    1565                 1570                 1575             


Pro Gly  Arg Xaa Leu Tyr Leu  Leu Ala Pro Ser Phe  Pro Asp Lys 
    1580                 1585                 1590             


Gln Arg  Trp Val Xaa Ala Leu  Glu Ser Val Val Ala  Gly Gly Arg 
    1595                 1600                 1605             


Val Ser  Arg Glu Lys Ala Glu  Ala Asp Ala Lys Leu  Leu Gly Asn 
    1610                 1615                 1620             


Ser Leu  Leu Lys Leu Glu Gly  Asp Asp Arg Leu Asp  Met Asn Cys 
    1625                 1630                 1635             


Xaa Leu  Pro Phe Ser Asp Gln  Val Val Leu Val Gly  Xaa Glu Glu 
    1640                 1645                 1650             


Gly Leu  Tyr Ala Leu Asn Val  Leu Lys Asn Ser Leu  Xaa His Val 
    1655                 1660                 1665             


Pro Gly  Ile Gly Ala Val Phe  Gln Ile Tyr Ile Ile  Lys Asp Leu 
    1670                 1675                 1680             


Glu Lys  Leu Leu Met Ile Ala  Gly Glu Glu Arg Ala  Leu Cys Leu 
    1685                 1690                 1695             


Val Asp  Val Lys Lys Val Lys  Gln Ser Leu Ala Gln  Ser His Leu 
    1700                 1705                 1710             


Pro Ala  Gln Pro Asp Ile Ser  Pro Asn Ile Phe Glu  Ala Val Lys 
    1715                 1720                 1725             


Gly Cys  His Leu Phe Gly Ala  Gly Lys Ile Glu Asn  Gly Leu Cys 
    1730                 1735                 1740             


Ile Cys  Ala Ala Met Pro Ser  Lys Val Val Ile Leu  Arg Tyr Asn 
    1745                 1750                 1755             


Glu Asn  Leu Ser Lys Tyr Cys  Ile Arg Lys Glu Ile  Glu Xaa Ser 
    1760                 1765                 1770             


Glu Pro  Cys Ser Cys Ile His  Phe Xaa Asn Tyr Ser  Ile Leu Ile 
    1775                 1780                 1785             


Gly Xaa  Asn Lys Phe Tyr Glu  Ile Asp Met Lys Gln  Tyr Xaa Leu 
    1790                 1795                 1800             


Glu Glu  Phe Leu Asp Lys Asn  Asp His Ser Leu Ala  Pro Ala Val 
    1805                 1810                 1815             


Phe Ala  Ala Ser Ser Asn Ser  Phe Pro Val Ser Ile  Val Gln Val 
    1820                 1825                 1830             


Asn Ser  Ala Gly Gln Arg Glu  Glu Tyr Leu Leu Cys  Phe His Glu 
    1835                 1840                 1845             


Phe Gly  Val Phe Val Asp Ser  Tyr Gly Arg Arg Ser  Arg Xaa Asp 
    1850                 1855                 1860             


Asp Leu  Lys Trp Ser Arg Leu  Pro Leu Ala Phe Ala  Tyr Arg Glu 
    1865                 1870                 1875             


Pro Tyr  Leu Phe Val Xaa His  Phe Asn Ser Leu Glu  Val Ile Glu 
    1880                 1885                 1890             


Ile Gln  Ala Arg Ser Ser Ala  Gly Xaa Pro Ala Arg  Ala Tyr Leu 
    1895                 1900                 1905             


Asp Ile  Pro Asn Pro Arg Tyr  Leu Gly Pro Ala Ile  Ser Ser Gly 
    1910                 1915                 1920             


Ala Ile  Tyr Leu Ala Ser Ser  Tyr Gln Asp Lys Leu  Arg Val Ile 
    1925                 1930                 1935             


Cys Cys  Lys Gly Asn Leu Val  Lys Glu Ser Gly Xaa  Glu His His 
    1940                 1945                 1950             


Arg Gly  Pro Ser Xaa Ser Arg  Ser Ser Pro Asn Lys  Arg Gly Pro 
    1955                 1960                 1965             


Pro Xaa  Tyr Asn Glu His Ile  Xaa Lys Arg Val Ala  Ser Ser Pro 
    1970                 1975                 1980             


Ala Pro  Pro Glu Gly Pro Ser  His Pro Arg Glu Pro  Ser Xaa Pro 
    1985                 1990                 1995             


His Arg  Tyr Arg Glu Gly Arg  Xaa Glu Leu Arg Arg  Asp Lys Ser 
    2000                 2005                 2010             


Pro Gly  Arg Pro Leu Glu Arg  Glu Lys Ser Pro Gly  Arg Met Leu 
    2015                 2020                 2025             


Ser Xaa  Arg Arg Glu Arg Ser  Pro Gly Arg Leu Phe  Glu Asp Ser 
    2030                 2035                 2040             


Ser Arg  Gly Arg Leu Pro Ala  Gly Ala Val Arg Xaa  Pro Leu Ser 
    2045                 2050                 2055             


Gln Val  Asn Lys Val Trp Asp  Gln Ser Ser Val 
    2060                 2065                 


<210> 6260
<211> 162
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<400> 6260
Met Arg Leu Leu Ala Pro Xaa Xaa Arg Leu Tyr Asn Cys Glu Val Lys 
1               5                   10                  15      


Trp Xaa Ile Ser Ala Gly Arg Ser Arg Asn Glu Arg Cys Ser Leu Pro 
            20                  25                  30          


Ala Arg Ser Lys Lys Ser Leu Phe Lys Asp Lys Ala Gln Ile Ser Ala 
        35                  40                  45              


Xaa Asp Leu Gln Xaa Met Glu Ala Leu Lys Xaa Xaa Cys Xaa Met Leu 
    50                  55                  60                  


Glu Glu Gln Val Met Asp Leu Glu Ala Leu Asn Asp Glu Leu Leu Glu 
65                  70                  75                  80  


Lys Glu Arg Gln Trp Glu Ala Trp Arg Ser Val Leu Gly Asp Glu Lys 
                85                  90                  95      


Ser Gln Phe Glu Cys Arg Val Arg Glu Leu Gln Arg Met Leu Asp Xaa 
            100                 105                 110         


Glu Lys Gln Ser Arg Ala Arg Ala Asp Gln Arg Ile Xaa Glu Ser Arg 
        115                 120                 125             


Gln Val Val Glu Leu Ala Val Lys Glu His Lys Ala Glu Ile Leu Ala 
    130                 135                 140                 


Leu Gln Gln Ala Leu Lys Glu Gln Lys Leu Lys Ala Glu Ser Leu Ser 
145                 150                 155                 160 


Asp Lys 
        


<210> 6261
<211> 1640
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1222)..(1222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1237)..(1237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1343)..(1343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1353)..(1353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1361)..(1361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1433)..(1433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1521)..(1521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1529)..(1529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1541)..(1541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1568)..(1568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1577)..(1577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1601)..(1601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1626)..(1626)
<223> Selenocysteine

<400> 6261
Xaa Pro Phe Val Pro Xaa Leu Lys Ser Asp Asp Asp Xaa Ser Asn Phe 
1               5                   10                  15      


Asp Glu Pro Glu Lys Asn Ser Trp Val Ser Ser Ser Pro Cys Gln Leu 
            20                  25                  30          


Ser Pro Ser Gly Phe Ser Gly Glu Glu Leu Pro Phe Val Gly Phe Ser 
        35                  40                  45              


Tyr Ser Lys Ala Leu Gly Ile Leu Gly Arg Ser Glu Ser Val Val Ser 
    50                  55                  60                  


Gly Leu Asp Ser Pro Ala Lys Xaa Ser Ser Met Glu Lys Lys Leu Leu 
65                  70                  75                  80  


Ile Lys Ser Lys Glu Leu Gln Asp Ser Gln Asp Lys Cys His Lys Met 
                85                  90                  95      


Glu Gln Glu Met Xaa Arg Leu His Arg Arg Val Ser Glu Val Glu Ala 
            100                 105                 110         


Val Leu Ser Gln Lys Glu Val Glu Leu Lys Ala Ser Glu Xaa Gln Arg 
        115                 120                 125             


Ser Leu Leu Glu Gln Asp Leu Ala Xaa Tyr Ile Xaa Glu Cys Ser Ser 
    130                 135                 140                 


Leu Lys Arg Ser Leu Glu Gln Ala Arg Met Glu Val Ser Gln Glu Asp 
145                 150                 155                 160 


Asp Lys Ala Leu Gln Leu Leu His Asp Ile Arg Glu Gln Ser Arg Lys 
                165                 170                 175     


Leu Gln Glu Ile Lys Glu Gln Glu Tyr Gln Ala Gln Val Glu Glu Met 
            180                 185                 190         


Arg Leu Met Met Asn Gln Leu Glu Glu Asp Leu Val Ser Ala Arg Arg 
        195                 200                 205             


Arg Ser Asp Leu Tyr Glu Ser Glu Leu Arg Glu Ser Arg Leu Ala Ala 
    210                 215                 220                 


Glu Glu Phe Lys Arg Lys Ala Xaa Glu Cys Gln His Lys Leu Leu Lys 
225                 230                 235                 240 


Ala Lys Asp Gln Gly Lys Pro Glu Val Gly Glu Tyr Ala Lys Leu Glu 
                245                 250                 255     


Lys Ile Asn Ala Glu Gln Gln Leu Lys Ile Gln Glu Leu Gln Glu Lys 
            260                 265                 270         


Leu Glu Lys Ala Val Lys Ala Ser Xaa Glu Ala Xaa Glu Leu Leu Gln 
        275                 280                 285             


Asn Ile Arg Gln Ala Lys Glu Arg Ala Glu Arg Glu Leu Glu Lys Leu 
    290                 295                 300                 


Gln Asn Arg Glu Asp Ser Ser Glu Gly Ile Arg Lys Lys Leu Val Glu 
305                 310                 315                 320 


Ala Glu Glu Leu Glu Glu Lys His Arg Glu Ala Gln Val Ser Ala Gln 
                325                 330                 335     


His Leu Glu Val His Leu Lys Gln Lys Glu Gln His Tyr Glu Glu Lys 
            340                 345                 350         


Ile Lys Val Leu Asp Asn Gln Ile Lys Lys Asp Leu Ala Asp Lys Glu 
        355                 360                 365             


Xaa Leu Glu Asn Met Met Gln Arg His Glu Glu Glu Ala His Glu Lys 
    370                 375                 380                 


Gly Lys Ile Leu Ser Glu Gln Lys Ala Met Ile Asn Ala Met Asp Ser 
385                 390                 395                 400 


Lys Ile Arg Ser Leu Glu Gln Arg Ile Val Glu Leu Ser Glu Ala Asn 
                405                 410                 415     


Lys Leu Ala Ala Asn Ser Ser Leu Phe Xaa Gln Arg Asn Met Lys Ala 
            420                 425                 430         


Gln Glu Glu Met Ile Ser Glu Leu Arg Gln Gln Lys Phe Tyr Leu Glu 
        435                 440                 445             


Xaa Gln Ala Gly Lys Leu Glu Ala Gln Asn Arg Lys Leu Glu Glu Gln 
    450                 455                 460                 


Leu Glu Lys Ile Ser His Gln Asp His Ser Asp Lys Asn Arg Leu Leu 
465                 470                 475                 480 


Glu Leu Glu Xaa Arg Leu Arg Glu Val Ser Leu Glu His Glu Glu Gln 
                485                 490                 495     


Lys Leu Glu Leu Lys Arg Gln Leu Xaa Glu Leu Gln Leu Ser Leu Gln 
            500                 505                 510         


Glu Arg Glu Ser Gln Leu Xaa Ala Leu Gln Ala Ala Arg Ala Ala Leu 
        515                 520                 525             


Glu Ser Gln Leu Arg Gln Ala Lys Xaa Glu Leu Glu Glu Xaa Xaa Ala 
    530                 535                 540                 


Glu Ala Glu Glu Glu Ile Gln Ala Leu Xaa Ala His Arg Asp Glu Ile 
545                 550                 555                 560 


Gln Arg Lys Phe Asp Ala Leu Arg Asn Ser Cys Xaa Val Ile Xaa Asp 
                565                 570                 575     


Leu Glu Glu Gln Leu Asn Gln Leu Xaa Glu Asp Asn Ala Glu Leu Asn 
            580                 585                 590         


Asn Gln Asn Phe Tyr Leu Ser Lys Gln Leu Asp Glu Ala Ser Gly Ala 
        595                 600                 605             


Asn Asp Glu Ile Val Gln Leu Arg Ser Glu Val Asp His Leu Arg Arg 
    610                 615                 620                 


Glu Ile Xaa Glu Arg Glu Met Gln Leu Xaa Ser Gln Lys Gln Xaa Met 
625                 630                 635                 640 


Glu Ala Leu Lys Xaa Xaa Cys Xaa Met Leu Glu Glu Gln Val Met Asp 
                645                 650                 655     


Leu Glu Ala Leu Asn Asp Glu Leu Leu Glu Lys Glu Arg Gln Trp Glu 
            660                 665                 670         


Ala Trp Arg Ser Val Leu Gly Asp Glu Lys Ser Gln Phe Glu Cys Arg 
        675                 680                 685             


Val Arg Glu Leu Gln Arg Met Leu Asp Xaa Glu Lys Gln Ser Arg Ala 
    690                 695                 700                 


Arg Ala Asp Gln Arg Ile Xaa Glu Ser Arg Gln Val Val Glu Leu Ala 
705                 710                 715                 720 


Val Lys Glu His Lys Ala Glu Ile Leu Ala Leu Gln Gln Ala Leu Lys 
                725                 730                 735     


Glu Gln Lys Leu Lys Ala Glu Ser Leu Ser Asp Lys Leu Asn Asp Leu 
            740                 745                 750         


Glu Lys Lys His Ala Met Leu Glu Met Asn Ala Arg Ser Leu Gln Gln 
        755                 760                 765             


Lys Leu Glu Xaa Glu Arg Glu Leu Lys Gln Arg Leu Leu Glu Glu Gln 
    770                 775                 780                 


Ala Lys Leu Gln Gln Gln Met Asp Leu Gln Lys Asn His Ile Phe Arg 
785                 790                 795                 800 


Leu Xaa Gln Gly Leu Gln Glu Ala Leu Asp Arg Ala Asp Leu Leu Lys 
                805                 810                 815     


Xaa Glu Arg Ser Asp Leu Glu Tyr Gln Leu Glu Asn Ile Gln Val Leu 
            820                 825                 830         


Tyr Ser His Glu Lys Val Lys Met Glu Gly Xaa Ile Ser Gln Gln Xaa 
        835                 840                 845             


Lys Leu Ile Asp Phe Leu Gln Ala Lys Met Asp Gln Pro Ala Lys Lys 
    850                 855                 860                 


Lys Lys Val Pro Leu Gln Tyr Asn Glu Leu Lys Leu Ala Leu Glu Lys 
865                 870                 875                 880 


Glu Lys Ala Arg Cys Ala Glu Leu Glu Glu Ala Leu Gln Lys Xaa Arg 
                885                 890                 895     


Ile Glu Leu Arg Ser Ala Arg Glu Glu Ala Ala His Arg Lys Ala Xaa 
            900                 905                 910         


Asp His Pro His Pro Ser Xaa Pro Ala Xaa Ala Arg Gln Gln Ile Ala 
        915                 920                 925             


Met Ser Ala Ile Val Arg Ser Pro Glu His Gln Pro Ser Ala Met Ser 
    930                 935                 940                 


Leu Leu Ala Pro Pro Ser Ser Arg Arg Lys Glu Ser Ser Xaa Pro Glu 
945                 950                 955                 960 


Glu Phe Ser Arg Arg Leu Lys Glu Arg Met His His Asn Ile Pro His 
                965                 970                 975     


Arg Phe Asn Val Gly Leu Asn Met Arg Ala Xaa Lys Cys Ala Val Cys 
            980                 985                 990         


Leu Asp Xaa Val His Phe Gly Arg  Gln Ala Ser Lys Cys  Leu Glu Cys 
        995                 1000                 1005             


Gln Val  Met Cys His Pro Lys  Cys Ser Xaa Cys Leu  Pro Ala Xaa 
    1010                 1015                 1020             


Cys Gly  Leu Pro Ala Glu Tyr  Ala Xaa His Phe Xaa  Glu Ala Phe 
    1025                 1030                 1035             


Cys Arg  Asp Lys Met Asn Ser  Pro Gly Leu Gln Xaa  Lys Glu Pro 
    1040                 1045                 1050             


Ser Ser  Ser Leu His Leu Glu  Gly Trp Met Lys Val  Pro Arg Asn 
    1055                 1060                 1065             


Asn Lys  Arg Gly Gln Gln Gly  Trp Asp Arg Lys Tyr  Ile Val Leu 
    1070                 1075                 1080             


Glu Gly  Ser Lys Val Leu Ile  Tyr Asp Asn Glu Ala  Arg Glu Ala 
    1085                 1090                 1095             


Gly Gln  Arg Pro Val Glu Glu  Phe Glu Leu Cys Leu  Pro Asp Gly 
    1100                 1105                 1110             


Asp Val  Ser Ile His Gly Ala  Val Gly Ala Ser Glu  Leu Ala Asn 
    1115                 1120                 1125             


Xaa Ala  Lys Ala Asp Val Pro  Tyr Ile Leu Lys Met  Glu Ser His 
    1130                 1135                 1140             


Pro His  Xaa Xaa Cys Trp Pro  Gly Arg Xaa Leu Tyr  Leu Leu Ala 
    1145                 1150                 1155             


Pro Ser  Phe Pro Asp Lys Gln  Arg Trp Val Xaa Ala  Leu Glu Ser 
    1160                 1165                 1170             


Val Val  Ala Gly Gly Arg Val  Ser Arg Glu Lys Ala  Glu Ala Asp 
    1175                 1180                 1185             


Ala Lys  Leu Leu Gly Asn Ser  Leu Leu Lys Leu Glu  Gly Asp Asp 
    1190                 1195                 1200             


Arg Leu  Asp Met Asn Cys Xaa  Leu Pro Phe Ser Asp  Gln Val Val 
    1205                 1210                 1215             


Leu Val  Gly Xaa Glu Glu Gly  Leu Tyr Ala Leu Asn  Val Leu Lys 
    1220                 1225                 1230             


Asn Ser  Leu Xaa His Val Pro  Gly Ile Gly Ala Val  Phe Gln Ile 
    1235                 1240                 1245             


Tyr Ile  Ile Lys Asp Leu Glu  Lys Leu Leu Met Ile  Ala Gly Glu 
    1250                 1255                 1260             


Glu Arg  Ala Leu Cys Leu Val  Asp Val Lys Lys Val  Lys Gln Ser 
    1265                 1270                 1275             


Leu Ala  Gln Ser His Leu Pro  Ala Gln Pro Asp Ile  Ser Pro Asn 
    1280                 1285                 1290             


Ile Phe  Glu Ala Val Lys Gly  Cys His Leu Phe Gly  Ala Gly Lys 
    1295                 1300                 1305             


Ile Glu  Asn Gly Leu Cys Ile  Cys Ala Ala Met Pro  Ser Lys Val 
    1310                 1315                 1320             


Val Ile  Leu Arg Tyr Asn Glu  Asn Leu Ser Lys Tyr  Cys Ile Arg 
    1325                 1330                 1335             


Lys Glu  Ile Glu Xaa Ser Glu  Pro Cys Ser Cys Ile  His Phe Xaa 
    1340                 1345                 1350             


Asn Tyr  Ser Ile Leu Ile Gly  Xaa Asn Lys Phe Tyr  Glu Ile Asp 
    1355                 1360                 1365             


Met Lys  Gln Tyr Xaa Leu Glu  Glu Phe Leu Asp Lys  Asn Asp His 
    1370                 1375                 1380             


Ser Leu  Ala Pro Ala Val Phe  Ala Ala Ser Ser Asn  Ser Phe Pro 
    1385                 1390                 1395             


Val Ser  Ile Val Gln Val Asn  Ser Ala Gly Gln Arg  Glu Glu Tyr 
    1400                 1405                 1410             


Leu Leu  Cys Phe His Glu Phe  Gly Val Phe Val Asp  Ser Tyr Gly 
    1415                 1420                 1425             


Arg Arg  Ser Arg Xaa Asp Asp  Leu Lys Trp Ser Arg  Leu Pro Leu 
    1430                 1435                 1440             


Ala Phe  Ala Tyr Arg Glu Pro  Tyr Leu Phe Val Xaa  His Phe Asn 
    1445                 1450                 1455             


Ser Leu  Glu Val Ile Glu Ile  Gln Ala Arg Ser Ser  Ala Gly Xaa 
    1460                 1465                 1470             


Pro Ala  Arg Ala Tyr Leu Asp  Ile Pro Asn Pro Arg  Tyr Leu Gly 
    1475                 1480                 1485             


Pro Ala  Ile Ser Ser Gly Ala  Ile Tyr Leu Ala Ser  Ser Tyr Gln 
    1490                 1495                 1500             


Asp Lys  Leu Arg Val Ile Cys  Cys Lys Gly Asn Leu  Val Lys Glu 
    1505                 1510                 1515             


Ser Gly  Xaa Glu His His Arg  Gly Pro Ser Xaa Ser  Arg Ser Ser 
    1520                 1525                 1530             


Pro Asn  Lys Arg Gly Pro Pro  Xaa Tyr Asn Glu His  Ile Xaa Lys 
    1535                 1540                 1545             


Arg Val  Ala Ser Ser Pro Ala  Pro Pro Glu Gly Pro  Ser His Pro 
    1550                 1555                 1560             


Arg Glu  Pro Ser Xaa Pro His  Arg Tyr Arg Glu Gly  Arg Xaa Glu 
    1565                 1570                 1575             


Leu Arg  Arg Asp Lys Ser Pro  Gly Arg Pro Leu Glu  Arg Glu Lys 
    1580                 1585                 1590             


Ser Pro  Gly Arg Met Leu Ser  Xaa Arg Arg Glu Arg  Ser Pro Gly 
    1595                 1600                 1605             


Arg Leu  Phe Glu Asp Ser Ser  Arg Gly Arg Leu Pro  Ala Gly Ala 
    1610                 1615                 1620             


Val Arg  Xaa Pro Leu Ser Gln  Val Asn Lys Val Trp  Asp Gln Ser 
    1625                 1630                 1635             


Ser Val  
    1640 


<210> 6262
<211> 59
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<400> 6262
Met Glu Pro Ser Ala Gln Gln Leu Gln Leu Ala Ala Ser Leu Pro Ala 
1               5                   10                  15      


Asn Leu Ser Asn Phe Cys Gln Gly Ser Glu Met Pro Xaa Xaa Ser Arg 
            20                  25                  30          


Pro Ala Leu Asp Val Lys Gly Gly Xaa Ser Pro Ala Lys Glu Asp Ala 
        35                  40                  45              


Asn Gln Glu Met Ser Ser Val Ala Tyr Ser Asn 
    50                  55                  


<210> 6263
<211> 109
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<400> 6263
Met Glu Pro Ser Ala Gln Gln Leu Gln Leu Ala Ala Ser Leu Pro Ala 
1               5                   10                  15      


Asn Leu Ser Asn Phe Cys Gln Gly Ser Glu Met Pro Xaa Xaa Ser Arg 
            20                  25                  30          


Pro Ala Leu Asp Val Lys Gly Gly Xaa Ser Pro Ala Lys Glu Asp Ala 
        35                  40                  45              


Asn Gln Glu Met Ser Ser Val Ala Tyr Ser Asn Leu Ala Val Lys Asp 
    50                  55                  60                  


Arg Lys Ala Val Ala Ile Leu His Tyr Pro Gly Val Ala Ser Asn Gly 
65                  70                  75                  80  


Xaa Lys Ala Ser Gly Ala Pro Xaa Ser Ser Ser Gly Ser Pro Ile Gly 
                85                  90                  95      


Ser Pro Xaa Xaa Xaa Pro Pro Xaa Lys Pro Pro Ser Phe 
            100                 105                 


<210> 6264
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<400> 6264
Met Glu Pro Ser Ala Gln Gln Leu Gln Leu Ala Ala Ser Leu Pro Ala 
1               5                   10                  15      


Asn Leu Ser Asn Phe Cys Gln Gly Ser Glu Met Pro Xaa Xaa Ser Arg 
            20                  25                  30          


Pro Ala Leu Asp Val Lys Gly Gly Xaa Ser Pro Ala Lys Glu Asp Ala 
        35                  40                  45              


Asn Gln Glu Met Ser Ser Val Ala Tyr Ser Asn Leu Ala Val Lys Asp 
    50                  55                  60                  


Arg Lys Ala Val Ala Ile Leu His Tyr Pro Gly Val Ala Ser Asn Gly 
65                  70                  75                  80  


Xaa Lys Ala Ser Gly Ala Pro Xaa Ser Ser Ser Gly Ser Pro Ile Gly 
                85                  90                  95      


Ser Pro Xaa Xaa Xaa Pro Pro Xaa Lys Pro Pro Ser Phe Asn Leu His 
            100                 105                 110         


Pro Ala Pro His Leu Leu Ala Ser Met His Leu Gln Lys Leu Asn Ser 
        115                 120                 125             


Gln Tyr Gln Gly Met Ala Ala Ala Xaa Pro 
    130                 135             


<210> 6265
<211> 219
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<400> 6265
Met Glu Pro Ser Ala Gln Gln Leu Gln Leu Ala Ala Ser Leu Pro Ala 
1               5                   10                  15      


Asn Leu Ser Asn Phe Cys Gln Gly Ser Glu Met Pro Xaa Xaa Ser Arg 
            20                  25                  30          


Pro Ala Leu Asp Val Lys Gly Gly Xaa Ser Pro Ala Lys Glu Asp Ala 
        35                  40                  45              


Asn Gln Glu Met Ser Ser Val Ala Tyr Ser Asn Leu Ala Val Lys Asp 
    50                  55                  60                  


Arg Lys Ala Val Ala Ile Leu His Tyr Pro Gly Val Ala Ser Asn Gly 
65                  70                  75                  80  


Xaa Lys Ala Ser Gly Ala Pro Xaa Ser Ser Ser Gly Ser Pro Ile Gly 
                85                  90                  95      


Ser Pro Xaa Xaa Xaa Pro Pro Xaa Lys Pro Pro Ser Phe Asn Leu His 
            100                 105                 110         


Pro Ala Pro His Leu Leu Ala Ser Met His Leu Gln Lys Leu Asn Ser 
        115                 120                 125             


Gln Tyr Gln Gly Met Ala Ala Ala Xaa Pro Gly Gln Pro Gly Glu Ala 
    130                 135                 140                 


Gly Pro Leu Gln Asn Trp Asp Phe Gly Ala Gln Ala Gly Gly Ala Glu 
145                 150                 155                 160 


Ser Leu Ser Pro Ser Ala Gly Ala Gln Ser Pro Ala Ile Ile Asp Ser 
                165                 170                 175     


Asp Pro Val Asp Glu Glu Val Leu Met Ser Leu Val Val Glu Leu Gly 
            180                 185                 190         


Leu Asp Arg Ala Asn Glu Leu Pro Glu Leu Trp Leu Gly Gln Asn Glu 
        195                 200                 205             


Phe Asp Phe Xaa Ala Asp Phe Pro Ser Ser Cys 
    210                 215                 


<210> 6266
<211> 141
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 6266
Met Pro Xaa Xaa Ser Arg Pro Ala Leu Asp Val Lys Gly Gly Xaa Ser 
1               5                   10                  15      


Pro Ala Lys Glu Asp Ala Asn Gln Glu Met Ser Ser Val Ala Tyr Ser 
            20                  25                  30          


Asn Leu Ala Val Lys Asp Arg Lys Ala Val Ala Ile Leu His Tyr Pro 
        35                  40                  45              


Gly Val Ala Ser Asn Gly Xaa Lys Ala Ser Gly Ala Pro Xaa Ser Ser 
    50                  55                  60                  


Ser Gly Ser Pro Ile Gly Ser Pro Xaa Xaa Xaa Pro Pro Xaa Lys Pro 
65                  70                  75                  80  


Pro Ser Phe Asn Leu His Pro Ala Pro His Leu Leu Ala Ser Met His 
                85                  90                  95      


Leu Gln Lys Leu Asn Ser Gln Tyr Gln Gly Met Ala Ala Ala Xaa Pro 
            100                 105                 110         


Gly Gln Pro Gly Glu Ala Gly Pro Leu Gln Asn Trp Asp Phe Gly Ala 
        115                 120                 125             


Gln Ala Gly Gly Ala Glu Ser Leu Ser Pro Ser Ala Gly 
    130                 135                 140     


<210> 6267
<211> 193
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<400> 6267
Met Pro Xaa Xaa Ser Arg Pro Ala Leu Asp Val Lys Gly Gly Xaa Ser 
1               5                   10                  15      


Pro Ala Lys Glu Asp Ala Asn Gln Glu Met Ser Ser Val Ala Tyr Ser 
            20                  25                  30          


Asn Leu Ala Val Lys Asp Arg Lys Ala Val Ala Ile Leu His Tyr Pro 
        35                  40                  45              


Gly Val Ala Ser Asn Gly Xaa Lys Ala Ser Gly Ala Pro Xaa Ser Ser 
    50                  55                  60                  


Ser Gly Ser Pro Ile Gly Ser Pro Xaa Xaa Xaa Pro Pro Xaa Lys Pro 
65                  70                  75                  80  


Pro Ser Phe Asn Leu His Pro Ala Pro His Leu Leu Ala Ser Met His 
                85                  90                  95      


Leu Gln Lys Leu Asn Ser Gln Tyr Gln Gly Met Ala Ala Ala Xaa Pro 
            100                 105                 110         


Gly Gln Pro Gly Glu Ala Gly Pro Leu Gln Asn Trp Asp Phe Gly Ala 
        115                 120                 125             


Gln Ala Gly Gly Ala Glu Ser Leu Ser Pro Ser Ala Gly Ala Gln Ser 
    130                 135                 140                 


Pro Ala Ile Ile Asp Ser Asp Pro Val Asp Glu Glu Val Leu Met Ser 
145                 150                 155                 160 


Leu Val Val Glu Leu Gly Leu Asp Arg Ala Asn Glu Leu Pro Glu Leu 
                165                 170                 175     


Trp Leu Gly Gln Asn Glu Phe Asp Phe Xaa Ala Asp Phe Pro Ser Ser 
            180                 185                 190         


Cys 
    


<210> 6268
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<400> 6268
Xaa Pro Xaa Xaa Ser Arg Pro Ala Leu Asp Val Lys Gly Gly Xaa Ser 
1               5                   10                  15      


Pro Ala Lys Glu Asp Ala Asn Gln Glu Met Ser Ser Val Ala Tyr Ser 
            20                  25                  30          


Asn Leu Ala Val Lys Asp Arg Lys Ala Val Ala Ile Leu His Tyr Pro 
        35                  40                  45              


Gly Val Ala Ser Asn Gly Xaa Lys Ser Pro Ala Ile Ile Asp Ser Asp 
    50                  55                  60                  


Pro Val Asp Glu Glu Val Leu Met Ser Leu Val Val Glu Leu Gly Leu 
65                  70                  75                  80  


Asp Arg Ala Asn Glu Leu Pro Glu Leu Trp Leu Gly Gln Asn Glu Phe 
                85                  90                  95      


Asp Phe Xaa Ala Asp Phe Pro Ser Ser Cys 
            100                 105     


<210> 6269
<211> 270
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<400> 6269
Met Ala Asp His Met Met Ala Met Asn His Gly Arg Phe Pro Asp Gly 
1               5                   10                  15      


Xaa Asn Gly Leu His His His Pro Ala His Arg Met Gly Met Gly Gln 
            20                  25                  30          


Phe Pro Ser Pro His His His Gln Gln Gln Gln Pro Gln His Ala Phe 
        35                  40                  45              


Asn Ala Leu Met Gly Glu His Ile His Tyr Gly Ala Gly Asn Met Asn 
    50                  55                  60                  


Ala Xaa Ser Gly Ile Arg His Ala Met Gly Pro Gly Xaa Val Asn Gly 
65                  70                  75                  80  


Gly His Pro Pro Ser Ala Leu Ala Pro Ala Ala Arg Phe Asn Asn Ser 
                85                  90                  95      


Gln Phe Met Gly Pro Pro Val Ala Ser Gln Gly Gly Ser Leu Pro Ala 
            100                 105                 110         


Ser Met Gln Leu Gln Lys Leu Asn Asn Gln Tyr Phe Asn His His Pro 
        115                 120                 125             


Tyr Pro His Asn His Tyr Met Pro Asp Leu His Pro Ala Ala Gly His 
    130                 135                 140                 


Gln Met Asn Gly Xaa Asn Gln His Phe Arg Asp Cys Asn Pro Lys His 
145                 150                 155                 160 


Ser Gly Gly Ser Ser Xaa Pro Gly Gly Ser Gly Gly Ser Ser Xaa Pro 
                165                 170                 175     


Gly Gly Ser Gly Ser Ser Ser Gly Gly Gly Ala Gly Ser Ser Asn Ser 
            180                 185                 190         


Gly Gly Gly Ser Gly Ser Gly Asn Met Pro Ala Ser Val Ala His Val 
        195                 200                 205             


Pro Ala Ala Met Leu Pro Pro Asn Val Ile Asp Xaa Asp Phe Ile Asp 
    210                 215                 220                 


Glu Glu Val Leu Met Ser Leu Val Ile Glu Met Gly Leu Asp Arg Ile 
225                 230                 235                 240 


Lys Glu Leu Pro Glu Leu Trp Leu Gly Gln Asn Glu Phe Asp Phe Met 
                245                 250                 255     


Xaa Asp Phe Val Cys Lys Gln Gln Pro Ser Arg Val Ser Cys 
            260                 265                 270 


<210> 6270
<211> 213
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<400> 6270
Met Ala Asp His Met Met Ala Met Asn His Gly Arg Phe Pro Asp Gly 
1               5                   10                  15      


Xaa Asn Gly Leu His His His Pro Ala His Arg Met Gly Met Gly Gln 
            20                  25                  30          


Phe Pro Ser Pro His His His Gln Gln Gln Gln Pro Gln His Ala Phe 
        35                  40                  45              


Asn Ala Leu Met Gly Glu His Ile His Tyr Gly Ala Gly Asn Met Asn 
    50                  55                  60                  


Ala Xaa Ser Gly Ile Arg His Ala Met Gly Pro Gly Xaa Val Asn Gly 
65                  70                  75                  80  


Gly His Pro Pro Ser Ala Leu Ala Pro Ala Ala Arg Phe Asn Asn Ser 
                85                  90                  95      


Gln Phe Met Gly Pro Pro Val Ala Ser Gln Gly Gly Ser Leu Pro Ala 
            100                 105                 110         


Ser Met Gln Leu Gln Lys Leu Asn Asn Gln Tyr Phe Asn His His Pro 
        115                 120                 125             


Tyr Pro His Asn His Tyr Met Pro Asp Leu His Pro Ala Ala Gly His 
    130                 135                 140                 


Gln Met Asn Gly Xaa Asn Gln His Phe Arg Asp Cys Asn Pro Asn Val 
145                 150                 155                 160 


Ile Asp Xaa Asp Phe Ile Asp Glu Glu Val Leu Met Ser Leu Val Ile 
                165                 170                 175     


Glu Met Gly Leu Asp Arg Ile Lys Glu Leu Pro Glu Leu Trp Leu Gly 
            180                 185                 190         


Gln Asn Glu Phe Asp Phe Met Xaa Asp Phe Val Cys Lys Gln Gln Pro 
        195                 200                 205             


Ser Arg Val Ser Cys 
    210             


<210> 6271
<211> 275
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<400> 6271
Met Ser Gly Leu Glu Met Ala Asp His Met Met Ala Met Asn His Gly 
1               5                   10                  15      


Arg Phe Pro Asp Gly Xaa Asn Gly Leu His His His Pro Ala His Arg 
            20                  25                  30          


Met Gly Met Gly Gln Phe Pro Ser Pro His His His Gln Gln Gln Gln 
        35                  40                  45              


Pro Gln His Ala Phe Asn Ala Leu Met Gly Glu His Ile His Tyr Gly 
    50                  55                  60                  


Ala Gly Asn Met Asn Ala Xaa Ser Gly Ile Arg His Ala Met Gly Pro 
65                  70                  75                  80  


Gly Xaa Val Asn Gly Gly His Pro Pro Ser Ala Leu Ala Pro Ala Ala 
                85                  90                  95      


Arg Phe Asn Asn Ser Gln Phe Met Gly Pro Pro Val Ala Ser Gln Gly 
            100                 105                 110         


Gly Ser Leu Pro Ala Ser Met Gln Leu Gln Lys Leu Asn Asn Gln Tyr 
        115                 120                 125             


Phe Asn His His Pro Tyr Pro His Asn His Tyr Met Pro Asp Leu His 
    130                 135                 140                 


Pro Ala Ala Gly His Gln Met Asn Gly Xaa Asn Gln His Phe Arg Asp 
145                 150                 155                 160 


Cys Asn Pro Lys His Ser Gly Gly Ser Ser Xaa Pro Gly Gly Ser Gly 
                165                 170                 175     


Gly Ser Ser Xaa Pro Gly Gly Ser Gly Ser Ser Ser Gly Gly Gly Ala 
            180                 185                 190         


Gly Ser Ser Asn Ser Gly Gly Gly Ser Gly Ser Gly Asn Met Pro Ala 
        195                 200                 205             


Ser Val Ala His Val Pro Ala Ala Met Leu Pro Pro Asn Val Ile Asp 
    210                 215                 220                 


Xaa Asp Phe Ile Asp Glu Glu Val Leu Met Ser Leu Val Ile Glu Met 
225                 230                 235                 240 


Gly Leu Asp Arg Ile Lys Glu Leu Pro Glu Leu Trp Leu Gly Gln Asn 
                245                 250                 255     


Glu Phe Asp Phe Met Xaa Asp Phe Val Cys Lys Gln Gln Pro Ser Arg 
            260                 265                 270         


Val Ser Cys 
        275 


<210> 6272
<211> 225
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<400> 6272
Met Asp Leu Arg Ala Gly Asp Ser Trp Gly Met Leu Ala Cys Leu Cys 
1               5                   10                  15      


Xaa Val Leu Trp His Leu Pro Ala Val Pro Ala Leu Asn Arg Xaa Gly 
            20                  25                  30          


Asp Pro Gly Pro Gly Pro Ser Ile Gln Lys Xaa Tyr Asp Leu Xaa Arg 
        35                  40                  45              


Tyr Leu Glu His Gln Leu Arg Ser Leu Ala Gly Xaa Tyr Leu Asn Tyr 
    50                  55                  60                  


Leu Gly Pro Pro Phe Asn Glu Pro Asp Phe Asn Pro Pro Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Xaa Leu Pro Arg Ala Xaa Val Asp Leu Glu Val Trp Arg Ser 
                85                  90                  95      


Leu Asn Asp Lys Leu Arg Leu Xaa Gln Asn Tyr Glu Ala Tyr Ser His 
            100                 105                 110         


Leu Leu Cys Tyr Leu Arg Gly Leu Asn Arg Gln Ala Ala Xaa Ala Glu 
        115                 120                 125             


Leu Arg Arg Ser Leu Ala His Phe Cys Xaa Ser Leu Gln Gly Leu Leu 
    130                 135                 140                 


Gly Ser Ile Ala Gly Val Met Ala Ala Leu Gly Tyr Pro Leu Pro Gln 
145                 150                 155                 160 


Pro Leu Pro Gly Xaa Glu Pro Xaa Trp Xaa Pro Gly Pro Ala His Ser 
                165                 170                 175     


Asp Phe Leu Gln Lys Met Asp Asp Phe Trp Leu Leu Lys Glu Leu Gln 
            180                 185                 190         


Xaa Trp Leu Trp Arg Ser Ala Lys Asp Phe Asn Arg Leu Lys Lys Lys 
        195                 200                 205             


Met Gln Pro Pro Ala Ala Ala Val Xaa Leu His Leu Gly Ala His Gly 
    210                 215                 220                 


Phe 
225 


<210> 6273
<211> 215
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<400> 6273
Met Leu Ala Cys Leu Cys Xaa Val Leu Trp His Leu Pro Ala Val Pro 
1               5                   10                  15      


Ala Leu Asn Arg Xaa Gly Asp Pro Gly Pro Gly Pro Ser Ile Gln Lys 
            20                  25                  30          


Xaa Tyr Asp Leu Xaa Arg Tyr Leu Glu His Gln Leu Arg Ser Leu Ala 
        35                  40                  45              


Gly Xaa Tyr Leu Asn Tyr Leu Gly Pro Pro Phe Asn Glu Pro Asp Phe 
    50                  55                  60                  


Asn Pro Pro Arg Leu Gly Ala Glu Xaa Leu Pro Arg Ala Xaa Val Asp 
65                  70                  75                  80  


Leu Glu Val Trp Arg Ser Leu Asn Asp Lys Leu Arg Leu Xaa Gln Asn 
                85                  90                  95      


Tyr Glu Ala Tyr Ser His Leu Leu Cys Tyr Leu Arg Gly Leu Asn Arg 
            100                 105                 110         


Gln Ala Ala Xaa Ala Glu Leu Arg Arg Ser Leu Ala His Phe Cys Xaa 
        115                 120                 125             


Ser Leu Gln Gly Leu Leu Gly Ser Ile Ala Gly Val Met Ala Ala Leu 
    130                 135                 140                 


Gly Tyr Pro Leu Pro Gln Pro Leu Pro Gly Xaa Glu Pro Xaa Trp Xaa 
145                 150                 155                 160 


Pro Gly Pro Ala His Ser Asp Phe Leu Gln Lys Met Asp Asp Phe Trp 
                165                 170                 175     


Leu Leu Lys Glu Leu Gln Xaa Trp Leu Trp Arg Ser Ala Lys Asp Phe 
            180                 185                 190         


Asn Arg Leu Lys Lys Lys Met Gln Pro Pro Ala Ala Ala Val Xaa Leu 
        195                 200                 205             


His Leu Gly Ala His Gly Phe 
    210                 215 


<210> 6274
<211> 847
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<400> 6274
Met Ala Gly Cys Arg Gly Ser Leu Cys Cys Cys Cys Arg Trp Cys Cys 
1               5                   10                  15      


Cys Cys Gly Glu Arg Glu Xaa Arg Xaa Pro Glu Glu Leu Xaa Ile Leu 
            20                  25                  30          


Gly Glu Xaa Gln Glu Glu Glu Asp Glu Ile Leu Pro Arg Lys Asp Tyr 
        35                  40                  45              


Glu Lys Gly Arg Arg Tyr Glu Ala Val Lys Trp Met Val Val Phe Ala 
    50                  55                  60                  


Ile Gly Val Cys Xaa Gly Leu Val Gly Leu Phe Val Asp Phe Phe Val 
65                  70                  75                  80  


Arg Leu Phe Xaa Gln Leu Lys Phe Gly Val Val Gln Xaa Ser Val Glu 
                85                  90                  95      


Glu Cys Ser Gln Lys Gly Cys Leu Ala Leu Ser Leu Leu Glu Leu Leu 
            100                 105                 110         


Gly Phe Asn Leu Xaa Phe Val Phe Leu Ala Ser Leu Leu Val Leu Ile 
        115                 120                 125             


Glu Pro Val Ala Ala Gly Ser Gly Ile Pro Glu Val Lys Cys Tyr Leu 
    130                 135                 140                 


Asn Gly Val Lys Val Pro Gly Ile Val Arg Leu Arg Xaa Leu Leu Cys 
145                 150                 155                 160 


Lys Val Leu Gly Val Leu Phe Ser Val Ala Gly Gly Leu Phe Val Glu 
                165                 170                 175     


Lys Glu Gly Pro Met Ile His Ser Gly Ser Val Val Gly Ala Gly Leu 
            180                 185                 190         


Pro Gln Phe Gln Ser Ile Ser Leu Arg Lys Ile Gln Phe Asn Phe Pro 
        195                 200                 205             


Tyr Phe Arg Ser Asp Arg Asp Lys Arg Asp Phe Val Ser Ala Gly Ala 
    210                 215                 220                 


Ala Ala Gly Val Ala Ala Ala Phe Gly Ala Pro Ile Gly Gly Xaa Leu 
225                 230                 235                 240 


Phe Ser Leu Glu Glu Gly Ser Ser Phe Trp Asn Gln Gly Leu Xaa Trp 
                245                 250                 255     


Lys Val Leu Phe Cys Ser Met Ser Ala Xaa Phe Xaa Leu Asn Phe Phe 
            260                 265                 270         


Arg Ser Gly Ile Gln Phe Gly Ser Trp Gly Ser Phe Gln Leu Pro Gly 
        275                 280                 285             


Leu Leu Asn Phe Gly Glu Phe Lys Cys Ser Asp Ser Asp Lys Lys Cys 
    290                 295                 300                 


His Leu Trp Xaa Ala Met Asp Leu Gly Phe Phe Val Val Met Gly Val 
305                 310                 315                 320 


Ile Gly Gly Leu Leu Gly Ala Xaa Phe Asn Cys Leu Asn Lys Arg Leu 
                325                 330                 335     


Ala Lys Tyr Arg Met Arg Asn Val His Pro Lys Pro Lys Leu Val Arg 
            340                 345                 350         


Val Leu Glu Ser Leu Leu Val Ser Leu Val Xaa Xaa Val Val Val Phe 
        355                 360                 365             


Val Ala Ser Met Val Leu Gly Glu Cys Arg Gln Met Ser Ser Ser Ser 
    370                 375                 380                 


Gln Ile Gly Asn Asp Ser Phe Gln Leu Gln Val Xaa Glu Asp Val Asn 
385                 390                 395                 400 


Ser Ser Ile Lys Xaa Phe Phe Cys Pro Asn Asp Xaa Tyr Asn Asp Met 
                405                 410                 415     


Ala Xaa Leu Phe Phe Asn Pro Gln Glu Ser Ala Ile Leu Gln Leu Phe 
            420                 425                 430         


His Gln Asp Gly Xaa Phe Ser Pro Val Xaa Leu Ala Leu Phe Phe Val 
        435                 440                 445             


Leu Tyr Phe Leu Leu Ala Cys Trp Xaa Tyr Gly Ile Ser Val Pro Ser 
    450                 455                 460                 


Gly Leu Phe Val Pro Ser Leu Leu Cys Gly Ala Ala Phe Gly Arg Leu 
465                 470                 475                 480 


Val Ala Asn Val Leu Lys Ser Tyr Ile Gly Leu Gly His Ile Tyr Ser 
                485                 490                 495     


Gly Xaa Phe Ala Leu Ile Gly Ala Ala Ala Phe Leu Gly Gly Val Val 
            500                 505                 510         


Arg Met Xaa Ile Ser Leu Xaa Val Ile Leu Ile Glu Ser Xaa Asn Glu 
        515                 520                 525             


Ile Xaa Tyr Gly Leu Pro Ile Met Val Xaa Leu Met Val Ala Lys Trp 
    530                 535                 540                 


Xaa Gly Asp Phe Phe Asn Lys Gly Ile Tyr Asp Ile His Val Gly Leu 
545                 550                 555                 560 


Arg Gly Val Pro Leu Leu Glu Trp Glu Xaa Glu Val Glu Met Asp Lys 
                565                 570                 575     


Leu Arg Ala Ser Asp Ile Met Glu Pro Asn Leu Xaa Tyr Val Tyr Pro 
            580                 585                 590         


His Xaa Arg Ile Gln Ser Leu Val Ser Ile Leu Arg Xaa Xaa Val His 
        595                 600                 605             


His Ala Phe Pro Val Val Xaa Glu Asn Arg Gly Asn Glu Lys Glu Phe 
    610                 615                 620                 


Met Lys Gly Asn Gln Leu Ile Ser Asn Asn Ile Lys Phe Lys Lys Ser 
625                 630                 635                 640 


Ser Ile Leu Xaa Arg Ala Gly Glu Gln Arg Lys Arg Ser Gln Ser Met 
                645                 650                 655     


Lys Ser Tyr Pro Ser Ser Glu Leu Arg Asn Met Cys Asp Glu His Ile 
            660                 665                 670         


Ala Ser Glu Glu Pro Ala Glu Lys Glu Asp Leu Leu Gln Gln Met Leu 
        675                 680                 685             


Glu Arg Arg Tyr Xaa Pro Tyr Pro Asn Leu Tyr Pro Asp Gln Ser Pro 
    690                 695                 700                 


Ser Glu Asp Trp Xaa Met Glu Glu Arg Phe Arg Pro Leu Xaa Phe His 
705                 710                 715                 720 


Gly Leu Ile Leu Arg Ser Gln Leu Val Xaa Leu Leu Val Arg Gly Val 
                725                 730                 735     


Cys Tyr Ser Glu Ser Gln Ser Ser Ala Ser Gln Pro Arg Leu Ser Tyr 
            740                 745                 750         


Ala Glu Met Ala Glu Asp Tyr Pro Arg Tyr Pro Asp Ile His Asp Leu 
        755                 760                 765             


Asp Leu Xaa Leu Leu Asn Pro Arg Met Ile Val Asp Val Xaa Pro Tyr 
    770                 775                 780                 


Met Asn Pro Ser Pro Phe Xaa Val Ser Pro Asn Xaa His Val Ser Gln 
785                 790                 795                 800 


Val Phe Asn Leu Phe Arg Xaa Met Gly Leu Arg His Leu Pro Val Val 
                805                 810                 815     


Asn Ala Val Gly Glu Ile Val Gly Ile Ile Xaa Arg His Asn Leu Xaa 
            820                 825                 830         


Tyr Glu Phe Leu Gln Ala Arg Leu Arg Gln His Tyr Gln Xaa Ile 
        835                 840                 845         


<210> 6275
<211> 869
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<400> 6275
Met Ala Gly Cys Arg Gly Ser Leu Cys Cys Cys Cys Arg Trp Cys Cys 
1               5                   10                  15      


Cys Cys Gly Glu Arg Glu Xaa Arg Xaa Pro Glu Glu Leu Xaa Ile Leu 
            20                  25                  30          


Gly Glu Xaa Gln Glu Glu Glu Asp Glu Ile Leu Pro Arg Lys Asp Tyr 
        35                  40                  45              


Glu Ser Leu Asp Tyr Asp Arg Cys Ile Asn Asp Pro Tyr Leu Glu Val 
    50                  55                  60                  


Leu Glu Xaa Met Asp Asn Lys Lys Gly Arg Arg Tyr Glu Ala Val Lys 
65                  70                  75                  80  


Trp Met Val Val Phe Ala Ile Gly Val Cys Xaa Gly Leu Val Gly Leu 
                85                  90                  95      


Phe Val Asp Phe Phe Val Arg Leu Phe Xaa Gln Leu Lys Phe Gly Val 
            100                 105                 110         


Val Gln Xaa Ser Val Glu Glu Cys Ser Gln Lys Gly Cys Leu Ala Leu 
        115                 120                 125             


Ser Leu Leu Glu Leu Leu Gly Phe Asn Leu Xaa Phe Val Phe Leu Ala 
    130                 135                 140                 


Ser Leu Leu Val Leu Ile Glu Pro Val Ala Ala Gly Ser Gly Ile Pro 
145                 150                 155                 160 


Glu Val Lys Cys Tyr Leu Asn Gly Val Lys Val Pro Gly Ile Val Arg 
                165                 170                 175     


Leu Arg Xaa Leu Leu Cys Lys Val Leu Gly Val Leu Phe Ser Val Ala 
            180                 185                 190         


Gly Gly Leu Phe Val Glu Lys Glu Gly Pro Met Ile His Ser Gly Ser 
        195                 200                 205             


Val Val Gly Ala Gly Leu Pro Gln Phe Gln Ser Ile Ser Leu Arg Lys 
    210                 215                 220                 


Ile Gln Phe Asn Phe Pro Tyr Phe Arg Ser Asp Arg Asp Lys Arg Asp 
225                 230                 235                 240 


Phe Val Ser Ala Gly Ala Ala Ala Gly Val Ala Ala Ala Phe Gly Ala 
                245                 250                 255     


Pro Ile Gly Gly Xaa Leu Phe Ser Leu Glu Glu Gly Ser Ser Phe Trp 
            260                 265                 270         


Asn Gln Gly Leu Xaa Trp Lys Val Leu Phe Cys Ser Met Ser Ala Xaa 
        275                 280                 285             


Phe Xaa Leu Asn Phe Phe Arg Ser Gly Ile Gln Phe Gly Ser Trp Gly 
    290                 295                 300                 


Ser Phe Gln Leu Pro Gly Leu Leu Asn Phe Gly Glu Phe Lys Cys Ser 
305                 310                 315                 320 


Asp Ser Asp Lys Lys Cys His Leu Trp Xaa Ala Met Asp Leu Gly Phe 
                325                 330                 335     


Phe Val Val Met Gly Val Ile Gly Gly Leu Leu Gly Ala Xaa Phe Asn 
            340                 345                 350         


Cys Leu Asn Lys Arg Leu Ala Lys Tyr Arg Met Arg Asn Val His Pro 
        355                 360                 365             


Lys Pro Lys Leu Val Arg Val Leu Glu Ser Leu Leu Val Ser Leu Val 
    370                 375                 380                 


Xaa Xaa Val Val Val Phe Val Ala Ser Met Val Leu Gly Glu Cys Arg 
385                 390                 395                 400 


Gln Met Ser Ser Ser Ser Gln Ile Gly Asn Asp Ser Phe Gln Leu Gln 
                405                 410                 415     


Val Xaa Glu Asp Val Asn Ser Ser Ile Lys Xaa Phe Phe Cys Pro Asn 
            420                 425                 430         


Asp Xaa Tyr Asn Asp Met Ala Xaa Leu Phe Phe Asn Pro Gln Glu Ser 
        435                 440                 445             


Ala Ile Leu Gln Leu Phe His Gln Asp Gly Xaa Phe Ser Pro Val Xaa 
    450                 455                 460                 


Leu Ala Leu Phe Phe Val Leu Tyr Phe Leu Leu Ala Cys Trp Xaa Tyr 
465                 470                 475                 480 


Gly Ile Ser Val Pro Ser Gly Leu Phe Val Pro Ser Leu Leu Cys Gly 
                485                 490                 495     


Ala Ala Phe Gly Arg Leu Val Ala Asn Val Leu Lys Ser Tyr Ile Gly 
            500                 505                 510         


Leu Gly His Ile Tyr Ser Gly Xaa Phe Ala Leu Ile Gly Ala Ala Ala 
        515                 520                 525             


Phe Leu Gly Gly Val Val Arg Met Xaa Ile Ser Leu Xaa Val Ile Leu 
    530                 535                 540                 


Ile Glu Ser Xaa Asn Glu Ile Xaa Tyr Gly Leu Pro Ile Met Val Xaa 
545                 550                 555                 560 


Leu Met Val Ala Lys Trp Xaa Gly Asp Phe Phe Asn Lys Gly Ile Tyr 
                565                 570                 575     


Asp Ile His Val Gly Leu Arg Gly Val Pro Leu Leu Glu Trp Glu Xaa 
            580                 585                 590         


Glu Val Glu Met Asp Lys Leu Arg Ala Ser Asp Ile Met Glu Pro Asn 
        595                 600                 605             


Leu Xaa Tyr Val Tyr Pro His Xaa Arg Ile Gln Ser Leu Val Ser Ile 
    610                 615                 620                 


Leu Arg Xaa Xaa Val His His Ala Phe Pro Val Val Xaa Glu Asn Arg 
625                 630                 635                 640 


Gly Asn Glu Lys Glu Phe Met Lys Gly Asn Gln Leu Ile Ser Asn Asn 
                645                 650                 655     


Ile Lys Phe Lys Lys Ser Ser Ile Leu Xaa Arg Ala Gly Glu Gln Arg 
            660                 665                 670         


Lys Arg Ser Gln Ser Met Lys Ser Tyr Pro Ser Ser Glu Leu Arg Asn 
        675                 680                 685             


Met Cys Asp Glu His Ile Ala Ser Glu Glu Pro Ala Glu Lys Glu Asp 
    690                 695                 700                 


Leu Leu Gln Gln Met Leu Glu Arg Arg Tyr Xaa Pro Tyr Pro Asn Leu 
705                 710                 715                 720 


Tyr Pro Asp Gln Ser Pro Ser Glu Asp Trp Xaa Met Glu Glu Arg Phe 
                725                 730                 735     


Arg Pro Leu Xaa Phe His Gly Leu Ile Leu Arg Ser Gln Leu Val Xaa 
            740                 745                 750         


Leu Leu Val Arg Gly Val Cys Tyr Ser Glu Ser Gln Ser Ser Ala Ser 
        755                 760                 765             


Gln Pro Arg Leu Ser Tyr Ala Glu Met Ala Glu Asp Tyr Pro Arg Tyr 
    770                 775                 780                 


Pro Asp Ile His Asp Leu Asp Leu Xaa Leu Leu Asn Pro Arg Met Ile 
785                 790                 795                 800 


Val Asp Val Xaa Pro Tyr Met Asn Pro Ser Pro Phe Xaa Val Ser Pro 
                805                 810                 815     


Asn Xaa His Val Ser Gln Val Phe Asn Leu Phe Arg Xaa Met Gly Leu 
            820                 825                 830         


Arg His Leu Pro Val Val Asn Ala Val Gly Glu Ile Val Gly Ile Ile 
        835                 840                 845             


Xaa Arg His Asn Leu Xaa Tyr Glu Phe Leu Gln Ala Arg Leu Arg Gln 
    850                 855                 860                 


His Tyr Gln Xaa Ile 
865                 


<210> 6276
<211> 953
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<400> 6276
Met Ala Gly Cys Arg Gly Ser Leu Cys Cys Cys Cys Arg Trp Cys Cys 
1               5                   10                  15      


Cys Cys Gly Glu Arg Glu Xaa Arg Xaa Pro Glu Glu Leu Xaa Ile Leu 
            20                  25                  30          


Gly Glu Xaa Gln Glu Glu Glu Asp Glu Ile Leu Pro Arg Lys Asp Tyr 
        35                  40                  45              


Glu Ser Leu Asp Tyr Asp Arg Cys Ile Asn Asp Pro Tyr Leu Glu Val 
    50                  55                  60                  


Leu Glu Xaa Met Asp Asn Lys Lys Gly Arg Arg Tyr Glu Ala Val Lys 
65                  70                  75                  80  


Trp Met Val Val Phe Ala Ile Gly Val Cys Xaa Gly Leu Val Gly Leu 
                85                  90                  95      


Phe Val Asp Phe Phe Val Arg Leu Phe Xaa Gln Leu Lys Phe Gly Val 
            100                 105                 110         


Val Gln Xaa Ser Val Glu Glu Cys Ser Gln Lys Gly Cys Leu Ala Leu 
        115                 120                 125             


Ser Leu Leu Glu Leu Leu Gly Phe Asn Leu Xaa Phe Val Phe Leu Ala 
    130                 135                 140                 


Ser Leu Leu Val Leu Ile Glu Pro Val Ala Ala Gly Ser Gly Ile Pro 
145                 150                 155                 160 


Glu Val Lys Cys Tyr Leu Asn Gly Val Lys Val Pro Gly Ile Val Arg 
                165                 170                 175     


Leu Arg Xaa Leu Leu Cys Lys Val Leu Gly Val Leu Phe Ser Val Ala 
            180                 185                 190         


Gly Gly Leu Phe Val Glu Lys Glu Gly Pro Met Ile His Ser Gly Ser 
        195                 200                 205             


Val Val Gly Ala Gly Leu Pro Gln Phe Gln Ser Ile Ser Leu Arg Lys 
    210                 215                 220                 


Ile Gln Phe Asn Phe Pro Tyr Phe Arg Ser Asp Arg Asp Lys Arg Asp 
225                 230                 235                 240 


Phe Val Ser Ala Gly Ala Ala Ala Gly Val Ala Ala Ala Phe Gly Ala 
                245                 250                 255     


Pro Ile Gly Gly Xaa Leu Phe Ser Leu Glu Glu Gly Ser Ser Phe Trp 
            260                 265                 270         


Asn Gln Gly Leu Xaa Trp Lys Val Leu Phe Cys Ser Met Ser Ala Xaa 
        275                 280                 285             


Phe Xaa Leu Asn Phe Phe Arg Ser Gly Ile Gln Phe Gly Ser Trp Gly 
    290                 295                 300                 


Ser Phe Gln Leu Pro Gly Leu Leu Asn Phe Gly Glu Phe Lys Cys Ser 
305                 310                 315                 320 


Asp Ser Asp Lys Lys Cys His Leu Trp Xaa Ala Met Asp Leu Gly Phe 
                325                 330                 335     


Phe Val Val Met Gly Val Ile Gly Gly Leu Leu Gly Ala Xaa Phe Asn 
            340                 345                 350         


Cys Leu Asn Lys Arg Leu Ala Lys Tyr Arg Met Arg Asn Val His Pro 
        355                 360                 365             


Lys Pro Lys Leu Val Arg Val Leu Glu Ser Leu Leu Val Ser Leu Val 
    370                 375                 380                 


Xaa Xaa Val Val Val Phe Val Ala Ser Met Val Leu Gly Glu Cys Arg 
385                 390                 395                 400 


Gln Met Ser Ser Ser Ser Gln Ile Gly Asn Asp Ser Phe Gln Leu Gln 
                405                 410                 415     


Val Xaa Glu Asp Val Asn Ser Ser Ile Lys Xaa Phe Phe Cys Pro Asn 
            420                 425                 430         


Asp Xaa Tyr Asn Asp Met Ala Xaa Leu Phe Phe Asn Pro Gln Glu Ser 
        435                 440                 445             


Ala Ile Leu Gln Leu Phe His Gln Asp Gly Xaa Phe Ser Pro Val Xaa 
    450                 455                 460                 


Leu Ala Leu Phe Phe Val Leu Tyr Phe Leu Leu Ala Cys Trp Xaa Tyr 
465                 470                 475                 480 


Gly Ile Ser Val Pro Ser Gly Leu Phe Val Pro Ser Leu Leu Cys Gly 
                485                 490                 495     


Ala Ala Phe Gly Arg Leu Val Ala Asn Val Leu Lys Ser Tyr Ile Gly 
            500                 505                 510         


Leu Gly His Ile Tyr Ser Gly Xaa Phe Ala Leu Ile Gly Ala Ala Ala 
        515                 520                 525             


Phe Leu Gly Gly Val Val Arg Met Xaa Ile Ser Leu Xaa Val Ile Leu 
    530                 535                 540                 


Ile Glu Ser Xaa Asn Glu Ile Xaa Tyr Gly Leu Pro Ile Met Val Xaa 
545                 550                 555                 560 


Leu Met Val Ala Lys Trp Xaa Gly Asp Phe Phe Asn Lys Gly Ile Tyr 
                565                 570                 575     


Asp Ile His Val Gly Leu Arg Gly Val Pro Leu Leu Glu Trp Glu Xaa 
            580                 585                 590         


Glu Val Glu Met Asp Lys Leu Arg Ala Ser Asp Ile Met Glu Pro Asn 
        595                 600                 605             


Leu Xaa Tyr Val Tyr Pro His Xaa Arg Ile Gln Ser Leu Val Ser Ile 
    610                 615                 620                 


Leu Arg Xaa Xaa Val His His Ala Phe Pro Val Val Xaa Glu Asn Arg 
625                 630                 635                 640 


Gly Asn Glu Lys Glu Phe Met Lys Gly Asn Gln Leu Ile Ser Asn Asn 
                645                 650                 655     


Ile Lys Phe Lys Lys Ser Ser Ile Leu Xaa Arg Ala Gly Glu Gln Arg 
            660                 665                 670         


Lys Arg Ser Gln Ser Met Lys Ser Tyr Pro Ser Ser Glu Leu Arg Asn 
        675                 680                 685             


Met Cys Asp Glu His Ile Ala Ser Glu Glu Pro Ala Glu Lys Glu Asp 
    690                 695                 700                 


Leu Leu Gln Gln Met Leu Glu Arg Arg Tyr Xaa Pro Tyr Pro Asn Leu 
705                 710                 715                 720 


Tyr Pro Asp Gln Ser Pro Ser Glu Asp Trp Xaa Met Glu Glu Arg Phe 
                725                 730                 735     


Arg Pro Leu Xaa Phe His Gly Leu Ile Leu Arg Ser Gln Leu Val Xaa 
            740                 745                 750         


Leu Leu Val Arg Gly Val Cys Tyr Ser Glu Ser Gln Ser Ser Ala Ser 
        755                 760                 765             


Gln Pro Arg Leu Ser Tyr Ala Glu Met Ala Glu Asp Tyr Pro Arg Tyr 
    770                 775                 780                 


Pro Asp Ile His Asp Leu Asp Leu Xaa Leu Leu Asn Pro Arg Met Ile 
785                 790                 795                 800 


Val Asp Val Xaa Pro Tyr Met Asn Pro Ser Pro Phe Xaa Val Ser Pro 
                805                 810                 815     


Asn Xaa His Val Ser Gln Val Phe Asn Leu Phe Arg Xaa Met Gly Leu 
            820                 825                 830         


Arg His Leu Pro Val Val Asn Ala Val Gly Glu Val Ser Glu Ala Pro 
        835                 840                 845             


Ala Leu Pro Pro Pro Leu Arg Glu Asp Pro Leu Ala Arg Cys Cys Leu 
    850                 855                 860                 


Cys Xaa Gln Ala Ser His Gln Lys Arg Arg His Pro Xaa Arg Arg Gly 
865                 870                 875                 880 


Glu Cys Gly Pro Xaa Leu Ala Leu Asn Pro Ala Arg Leu Pro Cys Xaa 
                885                 890                 895     


Arg Asp Pro Phe Pro Cys Leu Pro Ala Asp Gly Xaa Ser Val Pro Leu 
            900                 905                 910         


Ala Val Leu Ser Ser Gln Ser Arg Ala Ser Xaa Arg Leu Cys Leu Pro 
        915                 920                 925             


Pro Glu Met Leu Leu Phe Xaa Pro Tyr His Trp Cys Ser Leu Val Leu 
    930                 935                 940                 


His Leu Arg Arg Asp Leu Arg Ile Arg 
945                 950             


<210> 6277
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 6277
Met Ala Gly Cys Arg Gly Ser Leu Cys Cys Cys Cys Arg Trp Cys Cys 
1               5                   10                  15      


Cys Cys Gly Glu Arg Glu Xaa Arg Xaa Pro Glu Glu Leu Xaa Ile Leu 
            20                  25                  30          


Gly Glu Xaa Gln Glu Glu Glu Asp Glu Ile Leu Pro Arg Lys Asp Tyr 
        35                  40                  45              


Glu Ser Leu Asp Tyr Asp Arg Cys Ile Asn Asp Pro Tyr Leu Glu Val 
    50                  55                  60                  


Leu Glu Xaa Met Asp Asn Lys Lys Gly Arg Arg Tyr Glu Ala Val Lys 
65                  70                  75                  80  


Trp Met Val Val Phe Ala Ile Gly Val Cys Xaa Gly Leu Val Gly Leu 
                85                  90                  95      


Phe Val Asp Phe Phe Val Arg Leu Phe Xaa Gln Leu Lys Phe Gly Val 
            100                 105                 110         


Val Gln Xaa Tyr Lys Phe Gln Met Lys Met 
        115                 120         


<210> 6278
<211> 261
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<400> 6278
Met Ala Val Xaa Ala Cys Gln Gly Leu Gly Phe Val Val Ser Leu Ile 
1               5                   10                  15      


Gly Ile Ala Gly Ile Ile Ala Ala Xaa Cys Met Asp Gln Trp Ser Xaa 
            20                  25                  30          


Gln Asp Leu Tyr Asn Asn Pro Val Xaa Ala Val Phe Asn Tyr Gln Gly 
        35                  40                  45              


Leu Trp Arg Ser Cys Val Arg Glu Ser Ser Gly Phe Xaa Glu Cys Arg 
    50                  55                  60                  


Gly Tyr Phe Xaa Leu Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg 
65                  70                  75                  80  


Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val 
                85                  90                  95      


Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser 
            100                 105                 110         


Ala Lys Ala Asn Met Xaa Leu Xaa Ser Gly Ile Met Phe Ile Val Ser 
        115                 120                 125             


Gly Leu Cys Ala Ile Ala Gly Val Ser Val Phe Ala Asn Met Leu Val 
    130                 135                 140                 


Xaa Asn Phe Trp Met Ser Xaa Ala Asn Met Tyr Xaa Gly Met Gly Gly 
145                 150                 155                 160 


Met Val Gln Xaa Val Gln Xaa Arg Tyr Xaa Phe Gly Ala Ala Leu Phe 
                165                 170                 175     


Val Gly Trp Val Ala Gly Gly Leu Xaa Leu Ile Gly Gly Val Met Met 
            180                 185                 190         


Cys Ile Ala Cys Arg Gly Leu Ala Pro Glu Glu Xaa Asn Tyr Lys Ala 
        195                 200                 205             


Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly 
    210                 215                 220                 


Phe Lys Ala Ser Xaa Gly Phe Gly Ser Asn Xaa Lys Asn Lys Lys Ile 
225                 230                 235                 240 


Tyr Asp Gly Gly Ala Arg Xaa Glu Asp Glu Val Gln Ser Tyr Pro Ser 
                245                 250                 255     


Lys His Asp Tyr Val 
            260     


<210> 6279
<211> 261
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<400> 6279
Met Ser Xaa Xaa Xaa Cys Gln Val Val Ala Phe Leu Leu Ser Ile Leu 
1               5                   10                  15      


Gly Leu Ala Gly Cys Ile Ala Ala Xaa Gly Met Asp Met Trp Ser Xaa 
            20                  25                  30          


Gln Asp Leu Tyr Asp Asn Pro Val Xaa Ser Val Phe Gln Tyr Glu Gly 
        35                  40                  45              


Leu Trp Arg Ser Cys Val Arg Gln Ser Ser Gly Phe Xaa Glu Cys Arg 
    50                  55                  60                  


Pro Tyr Phe Xaa Ile Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg 
65                  70                  75                  80  


Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val 
                85                  90                  95      


Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser 
            100                 105                 110         


Ala Lys Ala Asn Met Xaa Leu Xaa Ser Gly Ile Met Phe Ile Val Ser 
        115                 120                 125             


Gly Leu Cys Ala Ile Ala Gly Val Ser Val Phe Ala Asn Met Leu Val 
    130                 135                 140                 


Xaa Asn Phe Trp Met Ser Xaa Ala Asn Met Tyr Xaa Gly Met Gly Gly 
145                 150                 155                 160 


Met Val Gln Xaa Val Gln Xaa Arg Tyr Xaa Phe Gly Ala Ala Leu Phe 
                165                 170                 175     


Val Gly Trp Val Ala Gly Gly Leu Xaa Leu Ile Gly Gly Val Met Met 
            180                 185                 190         


Cys Ile Ala Cys Arg Gly Leu Ala Pro Glu Glu Xaa Asn Tyr Lys Ala 
        195                 200                 205             


Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly 
    210                 215                 220                 


Phe Lys Ala Ser Xaa Gly Phe Gly Ser Asn Xaa Lys Asn Lys Lys Ile 
225                 230                 235                 240 


Tyr Asp Gly Gly Ala Arg Xaa Glu Asp Glu Val Gln Ser Tyr Pro Ser 
                245                 250                 255     


Lys His Asp Tyr Val 
            260     


<210> 6280
<211> 146
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 6280
Met Ser Xaa Xaa Xaa Cys Gln Val Val Ala Phe Leu Leu Ser Ile Leu 
1               5                   10                  15      


Gly Leu Ala Gly Cys Ile Ala Ala Xaa Gly Met Asp Met Trp Ser Xaa 
            20                  25                  30          


Gln Asp Leu Tyr Asp Asn Pro Val Xaa Ser Val Phe Gln Tyr Glu Gly 
        35                  40                  45              


Leu Trp Arg Ser Cys Val Arg Gln Ser Ser Gly Phe Xaa Glu Cys Arg 
    50                  55                  60                  


Pro Tyr Phe Xaa Ile Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg 
65                  70                  75                  80  


Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val 
                85                  90                  95      


Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser 
            100                 105                 110         


Ala Lys Ala Asn Met Xaa Leu Xaa Ser Gly Ile Met Phe Ile Val Ser 
        115                 120                 125             


Gly Xaa His Leu Val Arg Leu Cys Ser Trp Ala Gly Ser Leu Glu Ala 
    130                 135                 140                 


Ser His 
145     


<210> 6281
<211> 220
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<400> 6281
Met Ser Met Gly Leu Glu Ile Xaa Gly Xaa Ala Leu Ala Val Leu Gly 
1               5                   10                  15      


Trp Leu Gly Xaa Ile Val Cys Cys Ala Leu Pro Met Trp Arg Val Ser 
            20                  25                  30          


Ala Phe Ile Gly Ser Asn Ile Ile Xaa Ser Gln Asn Ile Trp Glu Gly 
        35                  40                  45              


Leu Trp Met Asn Cys Val Val Gln Ser Xaa Gly Gln Met Gln Cys Lys 
    50                  55                  60                  


Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala Arg 
65                  70                  75                  80  


Ala Leu Ile Val Val Ala Ile Leu Leu Ala Ala Phe Gly Leu Leu Val 
                85                  90                  95      


Ala Leu Val Gly Ala Gln Cys Xaa Asn Cys Val Gln Asp Asp Xaa Ala 
            100                 105                 110         


Lys Ala Lys Ile Xaa Ile Val Ala Gly Val Leu Phe Leu Leu Ala Ala 
        115                 120                 125             


Leu Leu Xaa Leu Val Pro Val Ser Trp Ser Ala Asn Xaa Ile Ile Arg 
    130                 135                 140                 


Asp Phe Tyr Asn Pro Val Val Pro Glu Ala Gln Lys Arg Glu Met Gly 
145                 150                 155                 160 


Ala Gly Leu Tyr Val Gly Trp Ala Ala Ala Ala Leu Gln Leu Leu Gly 
                165                 170                 175     


Gly Ala Leu Leu Cys Cys Ser Cys Pro Pro Arg Glu Lys Lys Tyr Xaa 
            180                 185                 190         


Ala Xaa Lys Val Val Tyr Ser Ala Pro Arg Ser Xaa Gly Pro Gly Ala 
        195                 200                 205             


Ser Leu Gly Xaa Gly Tyr Asp Arg Lys Asp Tyr Val 
    210                 215                 220 


<210> 6282
<211> 209
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<400> 6282
Met Ala Ser Met Gly Leu Gln Val Met Gly Ile Ala Leu Ala Val Leu 
1               5                   10                  15      


Gly Trp Leu Ala Val Met Leu Cys Cys Ala Leu Pro Met Trp Arg Val 
            20                  25                  30          


Xaa Ala Phe Ile Gly Ser Asn Ile Val Xaa Ser Gln Xaa Ile Trp Glu 
        35                  40                  45              


Gly Leu Trp Met Asn Cys Val Val Gln Ser Xaa Gly Gln Met Gln Cys 
    50                  55                  60                  


Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Val Ile Ile Ser Ile Ile Val Ala Ala Leu Gly Val Leu 
                85                  90                  95      


Leu Ser Val Val Gly Gly Lys Cys Xaa Asn Cys Leu Glu Asp Glu Ser 
            100                 105                 110         


Ala Lys Ala Lys Xaa Met Ile Val Ala Gly Val Val Phe Leu Leu Ala 
        115                 120                 125             


Gly Leu Met Val Ile Val Pro Val Ser Trp Xaa Ala His Asn Ile Ile 
    130                 135                 140                 


Gln Asp Phe Tyr Asn Pro Leu Val Ala Ser Gly Gln Lys Arg Glu Met 
145                 150                 155                 160 


Gly Ala Ser Leu Tyr Val Gly Trp Ala Ala Ser Gly Leu Leu Leu Leu 
                165                 170                 175     


Gly Gly Gly Leu Leu Cys Cys Asn Cys Pro Pro Arg Xaa Asp Lys Pro 
            180                 185                 190         


Tyr Ser Ala Lys Tyr Ser Ala Ala Arg Ser Ala Ala Ala Ser Asn Tyr 
        195                 200                 205             


Val 
    


<210> 6283
<211> 218
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<400> 6283
Met Gly Ser Ala Ala Leu Glu Ile Leu Gly Leu Val Leu Cys Leu Val 
1               5                   10                  15      


Gly Trp Gly Gly Leu Ile Leu Ala Cys Gly Leu Pro Met Trp Gln Val 
            20                  25                  30          


Xaa Ala Phe Leu Asp His Asn Ile Val Xaa Ala Gln Xaa Xaa Trp Lys 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Val Gln Ser Xaa Gly His Met Gln Cys 
    50                  55                  60                  


Lys Val Tyr Asp Ser Val Leu Ala Leu Ser Xaa Glu Val Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Xaa Val Ser Ala Val Leu Leu Ala Phe Val Ala Leu Phe 
                85                  90                  95      


Val Xaa Leu Ala Gly Ala Gln Cys Xaa Xaa Cys Val Ala Pro Gly Pro 
            100                 105                 110         


Ala Lys Ala Arg Val Ala Leu Xaa Gly Gly Val Leu Tyr Leu Phe Cys 
        115                 120                 125             


Gly Leu Leu Ala Leu Val Pro Leu Cys Trp Phe Ala Asn Ile Val Val 
    130                 135                 140                 


Arg Glu Phe Tyr Asp Pro Ser Val Pro Val Ser Gln Lys Tyr Glu Leu 
145                 150                 155                 160 


Gly Ala Ala Leu Tyr Ile Gly Trp Ala Ala Xaa Ala Leu Leu Met Val 
                165                 170                 175     


Gly Gly Cys Leu Leu Cys Cys Gly Ala Trp Val Cys Xaa Gly Arg Pro 
            180                 185                 190         


Asp Leu Ser Phe Pro Val Lys Tyr Ser Ala Pro Arg Arg Pro Xaa Ala 
        195                 200                 205             


Xaa Gly Asp Tyr Asp Lys Lys Asn Tyr Val 
    210                 215             


<210> 6284
<211> 303
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<400> 6284
Met Xaa Arg Ala Arg Ile Gly Cys Phe Gly Pro Gly Gly Arg Ala Arg 
1               5                   10                  15      


Gly Xaa Glu Ser Ala Pro Glu Pro Ser Lys Arg Val Pro Pro Gly Arg 
            20                  25                  30          


Ser Trp Gln Xaa Gln Glu Val Arg Gln Xaa Arg Gly Ala Asn Gly Leu 
        35                  40                  45              


Gly Pro Arg Ala Gly Ser Ala Gly Ala Lys Ala Pro Gly Pro Ala Gln 
    50                  55                  60                  


Gly Ala Ala Gln His Gly Leu Gly Gly Ser Ala Gly Leu Arg Val Arg 
65                  70                  75                  80  


Val Ser Pro Leu Ala Met Gly Ser Ala Ala Leu Glu Ile Leu Gly Leu 
                85                  90                  95      


Val Leu Cys Leu Val Gly Trp Gly Gly Leu Ile Leu Ala Cys Gly Leu 
            100                 105                 110         


Pro Met Trp Gln Val Xaa Ala Phe Leu Asp His Asn Ile Val Xaa Ala 
        115                 120                 125             


Gln Xaa Xaa Trp Lys Gly Leu Trp Met Ser Cys Val Val Gln Ser Xaa 
    130                 135                 140                 


Gly His Met Gln Cys Lys Val Tyr Asp Ser Val Leu Ala Leu Ser Xaa 
145                 150                 155                 160 


Glu Val Gln Ala Ala Arg Ala Leu Xaa Val Ser Ala Val Leu Leu Ala 
                165                 170                 175     


Phe Val Ala Leu Phe Val Xaa Leu Ala Gly Ala Gln Cys Xaa Xaa Cys 
            180                 185                 190         


Val Ala Pro Gly Pro Ala Lys Ala Arg Val Ala Leu Xaa Gly Gly Val 
        195                 200                 205             


Leu Tyr Leu Phe Cys Gly Leu Leu Ala Leu Val Pro Leu Cys Trp Phe 
    210                 215                 220                 


Ala Asn Ile Val Val Arg Glu Phe Tyr Asp Pro Ser Val Pro Val Ser 
225                 230                 235                 240 


Gln Lys Tyr Glu Leu Gly Ala Ala Leu Tyr Ile Gly Trp Ala Ala Xaa 
                245                 250                 255     


Ala Leu Leu Met Val Gly Gly Cys Leu Leu Cys Cys Gly Ala Trp Val 
            260                 265                 270         


Cys Xaa Gly Arg Pro Asp Leu Ser Phe Pro Val Lys Tyr Ser Ala Pro 
        275                 280                 285             


Arg Arg Pro Xaa Ala Xaa Gly Asp Tyr Asp Lys Lys Asn Tyr Val 
    290                 295                 300             


<210> 6285
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<400> 6285
Met Gln Ala Lys Tyr Ser Ser Xaa Arg Asp Met Leu Asp Asp Asp Gly 
1               5                   10                  15      


Asp Xaa Xaa Met Ser Leu His Ser Gln Gly Ser Ala Xaa Xaa Arg His 
            20                  25                  30          


Pro Glu Pro Arg Arg Xaa Ala His Arg Cys Ser Pro Cys Xaa Glu Gln 
        35                  40                  45              


Trp Lys Trp His Gly Asp Asn Cys Tyr Gln Phe Tyr Lys Asp Ser Lys 
    50                  55                  60                  


Ser Trp Glu Asp Cys Lys Tyr Phe Cys Leu Ser Glu Asn Ser Xaa Met 
65                  70                  75                  80  


Leu Lys Ile Asn Lys Gln Glu Asp Leu Glu Phe Ala Ala Ser Gln Ser 
                85                  90                  95      


Tyr Ser Glu Phe Phe Tyr Ser Tyr Trp Xaa Gly Leu Leu Arg Pro Asp 
            100                 105                 110         


Ser Gly Lys Ala Trp Leu Trp Met Asp Gly Xaa Pro Phe Xaa Ser Glu 
        115                 120                 125             


Leu Phe His Ile Ile Ile Asp Val Xaa Ser Pro Arg Ser Arg Asp Cys 
    130                 135                 140                 


Val Ala Ile Leu Asn Gly Met Ile Phe Ser Lys Asp Cys Lys Glu Leu 
145                 150                 155                 160 


Lys Arg Cys Val Cys Glu Arg Arg Ala Gly Met Val Lys Pro Glu Ser 
                165                 170                 175     


Leu His Val Pro Pro Glu Xaa Leu Gly Glu Gly Asp 
            180                 185             


<210> 6286
<211> 70
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<400> 6286
Met Gln Ala Lys Tyr Ser Ser Xaa Arg Asp Met Leu Asp Asp Asp Gly 
1               5                   10                  15      


Asp Xaa Xaa Met Ser Leu His Ser Gln Gly Ser Ala Xaa Xaa Arg His 
            20                  25                  30          


Pro Glu Pro Arg Arg Xaa Glu His Arg Ala Pro Ser Ser Xaa Trp Arg 
        35                  40                  45              


Pro Val Ala Leu Xaa Leu Leu Xaa Leu Cys Leu Val Leu Leu Ile Gly 
    50                  55                  60                  


Leu Ala Ala Leu Gly Leu 
65                  70  


<210> 6287
<211> 280
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<400> 6287
Met Gln Ala Lys Tyr Ser Ser Xaa Arg Asp Met Leu Asp Asp Asp Gly 
1               5                   10                  15      


Asp Xaa Xaa Met Ser Leu His Ser Gln Gly Ser Ala Xaa Xaa Arg His 
            20                  25                  30          


Pro Glu Pro Arg Arg Xaa Glu His Arg Ala Pro Ser Ser Xaa Trp Arg 
        35                  40                  45              


Pro Val Ala Leu Xaa Leu Leu Xaa Leu Cys Leu Val Leu Leu Ile Gly 
    50                  55                  60                  


Leu Ala Ala Leu Gly Leu Leu Phe Phe Gln Tyr Tyr Gln Leu Ser Asn 
65                  70                  75                  80  


Xaa Gly Gln Asp Xaa Ile Ser Gln Met Glu Glu Arg Leu Gly Asn Xaa 
                85                  90                  95      


Ser Gln Glu Leu Gln Ser Leu Gln Val Gln Asn Ile Lys Leu Ala Gly 
            100                 105                 110         


Ser Leu Gln His Val Ala Glu Lys Leu Cys Arg Glu Leu Tyr Asn Lys 
        115                 120                 125             


Ala Gly Ala His Arg Cys Ser Pro Cys Xaa Glu Gln Trp Lys Trp His 
    130                 135                 140                 


Gly Asp Asn Cys Tyr Gln Phe Tyr Lys Asp Ser Lys Ser Trp Glu Asp 
145                 150                 155                 160 


Cys Lys Tyr Phe Cys Leu Ser Glu Asn Ser Xaa Met Leu Lys Ile Asn 
                165                 170                 175     


Lys Gln Glu Asp Leu Glu Phe Ala Ala Ser Gln Ser Tyr Ser Glu Phe 
            180                 185                 190         


Phe Tyr Ser Tyr Trp Xaa Gly Leu Leu Arg Pro Asp Ser Gly Lys Ala 
        195                 200                 205             


Trp Leu Trp Met Asp Gly Xaa Pro Phe Xaa Ser Glu Leu Phe His Ile 
    210                 215                 220                 


Ile Ile Asp Val Xaa Ser Pro Arg Ser Arg Asp Cys Val Ala Ile Leu 
225                 230                 235                 240 


Asn Gly Met Ile Phe Ser Lys Asp Cys Lys Glu Leu Lys Arg Cys Val 
                245                 250                 255     


Cys Glu Arg Arg Ala Gly Met Val Lys Pro Glu Ser Leu His Val Pro 
            260                 265                 270         


Pro Glu Xaa Leu Gly Glu Gly Asp 
        275                 280 


<210> 6288
<211> 66
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 6288
Met Gln Ala Lys Tyr Ser Ser Xaa Arg Asp Met Leu Asp Asp Asp Gly 
1               5                   10                  15      


Asp Xaa Xaa Met Ser Leu His Ser Gln Gly Ser Ala Xaa Xaa Arg His 
            20                  25                  30          


Pro Glu Pro Arg Arg Xaa Gly Trp Ser Arg Val Ala Arg Ser Arg Leu 
        35                  40                  45              


Xaa Ala Ala Leu Xaa Ser Leu Ala Gln Ala Ile Leu Pro Pro Gln Pro 
    50                  55                  60                  


Ser Glu 
65      


<210> 6289
<211> 247
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<400> 6289
Met Gln Ala Lys Tyr Ser Ser Xaa Arg Asp Met Leu Asp Asp Asp Gly 
1               5                   10                  15      


Asp Xaa Xaa Met Ser Leu His Ser Gln Gly Ser Ala Xaa Xaa Arg His 
            20                  25                  30          


Pro Glu Pro Arg Arg Xaa Val Phe Gln Tyr Tyr Gln Leu Ser Asn Xaa 
        35                  40                  45              


Gly Gln Asp Xaa Ile Ser Gln Met Glu Glu Arg Leu Gly Asn Xaa Ser 
    50                  55                  60                  


Gln Glu Leu Gln Ser Leu Gln Val Gln Asn Ile Lys Leu Ala Gly Ser 
65                  70                  75                  80  


Leu Gln His Val Ala Glu Lys Leu Cys Arg Glu Leu Tyr Asn Lys Ala 
                85                  90                  95      


Gly Ala His Arg Cys Ser Pro Cys Xaa Glu Gln Trp Lys Trp His Gly 
            100                 105                 110         


Asp Asn Cys Tyr Gln Phe Tyr Lys Asp Ser Lys Ser Trp Glu Asp Cys 
        115                 120                 125             


Lys Tyr Phe Cys Leu Ser Glu Asn Ser Xaa Met Leu Lys Ile Asn Lys 
    130                 135                 140                 


Gln Glu Asp Leu Glu Phe Ala Ala Ser Gln Ser Tyr Ser Glu Phe Phe 
145                 150                 155                 160 


Tyr Ser Tyr Trp Xaa Gly Leu Leu Arg Pro Asp Ser Gly Lys Ala Trp 
                165                 170                 175     


Leu Trp Met Asp Gly Xaa Pro Phe Xaa Ser Glu Leu Phe His Ile Ile 
            180                 185                 190         


Ile Asp Val Xaa Ser Pro Arg Ser Arg Asp Cys Val Ala Ile Leu Asn 
        195                 200                 205             


Gly Met Ile Phe Ser Lys Asp Cys Lys Glu Leu Lys Arg Cys Val Cys 
    210                 215                 220                 


Glu Arg Arg Ala Gly Met Val Lys Pro Glu Ser Leu His Val Pro Pro 
225                 230                 235                 240 


Glu Xaa Leu Gly Glu Gly Asp 
                245         


<210> 6290
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<400> 6290
Phe Lys Gly His Lys Cys Ser Pro Cys Asp Xaa Asn Trp Arg Tyr Tyr 
1               5                   10                  15      


Gly Asp Ser Cys Tyr Gly Phe Phe Arg His Asn Leu Xaa Trp Glu Glu 
            20                  25                  30          


Ser Lys Gln Tyr Cys Xaa Asp Met Asn Ala Xaa Leu Leu Lys Ile Asp 
        35                  40                  45              


Asn Arg Asn Ile Val Glu Tyr Ile Lys Ala Arg Xaa His Leu Ile Arg 
    50                  55                  60                  


Trp Val Gly Leu Ser Arg Gln Lys Ser Asn Glu Val Trp Lys Trp Glu 
65                  70                  75                  80  


Asp Gly Ser Val Ile Ser Glu Asn Met Lys Xaa Gln Ile Met Ile Phe 
                85                  90                  95      


<210> 6291
<211> 196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<400> 6291
Met Gln Asp Glu Asp Gly Tyr Ile Xaa Leu Asn Ile Lys Xaa Arg Lys 
1               5                   10                  15      


Pro Ala Leu Ile Ser Ala Val Met Gln Arg Asn Tyr Leu Gln Gly Glu 
            20                  25                  30          


Asn Glu Asn Arg Xaa Gly Xaa Leu Gln Gln Leu Ala Lys Arg Phe Cys 
        35                  40                  45              


Gln Tyr Val Val Lys Gln Ser Glu Leu Lys Gly Xaa Phe Lys Gly His 
    50                  55                  60                  


Lys Cys Ser Pro Cys Asp Xaa Asn Trp Arg Tyr Tyr Gly Asp Ser Cys 
65                  70                  75                  80  


Tyr Gly Phe Phe Arg His Asn Leu Xaa Trp Glu Glu Ser Lys Gln Tyr 
                85                  90                  95      


Cys Xaa Asp Met Asn Ala Xaa Leu Leu Lys Ile Asp Asn Arg Asn Ile 
            100                 105                 110         


Val Glu Tyr Ile Lys Ala Arg Xaa His Leu Ile Arg Trp Val Gly Leu 
        115                 120                 125             


Ser Arg Gln Lys Ser Asn Glu Val Trp Lys Trp Glu Asp Gly Ser Val 
    130                 135                 140                 


Ile Ser Glu Asn Met Phe Glu Phe Leu Glu Asp Gly Lys Gly Asn Met 
145                 150                 155                 160 


Asn Cys Ala Tyr Phe His Asn Gly Lys Met His Pro Xaa Phe Cys Glu 
                165                 170                 175     


Asn Lys His Tyr Leu Met Cys Glu Arg Lys Ala Gly Met Xaa Lys Val 
            180                 185                 190         


Asp Gln Leu Pro 
        195     


<210> 6292
<211> 229
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<400> 6292
Met Gln Asp Glu Asp Gly Tyr Ile Xaa Leu Asn Ile Lys Xaa Arg Lys 
1               5                   10                  15      


Pro Ala Leu Ile Ser Val Gly Ser Ala Ser Ser Ser Trp Trp Arg Val 
            20                  25                  30          


Met Ala Leu Ile Leu Leu Ile Leu Cys Val Gly Met Val Val Gly Leu 
        35                  40                  45              


Val Ala Leu Gly Ile Trp Ser Val Met Gln Arg Asn Tyr Leu Gln Gly 
    50                  55                  60                  


Glu Asn Glu Asn Arg Xaa Gly Xaa Leu Gln Gln Leu Ala Lys Arg Phe 
65                  70                  75                  80  


Cys Gln Tyr Val Val Lys Gln Ser Glu Leu Lys Gly Xaa Phe Lys Gly 
                85                  90                  95      


His Lys Cys Ser Pro Cys Asp Xaa Asn Trp Arg Tyr Tyr Gly Asp Ser 
            100                 105                 110         


Cys Tyr Gly Phe Phe Arg His Asn Leu Xaa Trp Glu Glu Ser Lys Gln 
        115                 120                 125             


Tyr Cys Xaa Asp Met Asn Ala Xaa Leu Leu Lys Ile Asp Asn Arg Asn 
    130                 135                 140                 


Ile Val Glu Tyr Ile Lys Ala Arg Xaa His Leu Ile Arg Trp Val Gly 
145                 150                 155                 160 


Leu Ser Arg Gln Lys Ser Asn Glu Val Trp Lys Trp Glu Asp Gly Ser 
                165                 170                 175     


Val Ile Ser Glu Asn Met Phe Glu Phe Leu Glu Asp Gly Lys Gly Asn 
            180                 185                 190         


Met Asn Cys Ala Tyr Phe His Asn Gly Lys Met His Pro Xaa Phe Cys 
        195                 200                 205             


Glu Asn Lys His Tyr Leu Met Cys Glu Arg Lys Ala Gly Met Xaa Lys 
    210                 215                 220                 


Val Asp Gln Leu Pro 
225                 


<210> 6293
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<400> 6293
Ala Ile Arg Ala Asn Cys His Gln Glu Pro Ser Val Cys Leu Gln Ala 
1               5                   10                  15      


Ala Cys Pro Glu Ser Trp Ile Gly Phe Gln Arg Lys Cys Phe Tyr Phe 
            20                  25                  30          


Ser Asp Asp Xaa Lys Asn Trp Xaa Ser Ser Gln Arg Phe Cys Asp Ser 
        35                  40                  45              


Gln Asp Ala Asp Leu Ala Gln Val Glu Ser Phe Gln Glu Leu Asn Phe 
    50                  55                  60                  


Leu Leu Arg Tyr Lys Gly Pro Ser Asp His Trp Ile Gly Leu Ser Arg 
65                  70                  75                  80  


Glu Gln Gly Gln Pro Trp Lys Trp Ile Asn Gly Xaa Glu Trp Xaa Arg 
                85                  90                  95      


Gln Asp Arg Val Leu Leu Cys Tyr Pro Gly Trp Ser Ala Val Val Pro 
            100                 105                 110         


Ser Trp Leu Xaa Ala Ala Leu Xaa Ser Leu Ala Gln Val Ser Leu Pro 
        115                 120                 125             


Ser Gln Pro Pro Glu 
    130             


<210> 6294
<211> 173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<400> 6294
Cys Leu His Ser Lys Glu His Ser Ile Lys Ala Xaa Leu Ile Trp Arg 
1               5                   10                  15      


Leu Phe Phe Leu Ile Met Phe Leu Xaa Ile Ile Val Cys Gly Met Val 
            20                  25                  30          


Ala Ala Leu Ser Ala Ile Arg Ala Asn Cys His Gln Glu Pro Ser Val 
        35                  40                  45              


Cys Leu Gln Ala Ala Cys Pro Glu Ser Trp Ile Gly Phe Gln Arg Lys 
    50                  55                  60                  


Cys Phe Tyr Phe Ser Asp Asp Xaa Lys Asn Trp Xaa Ser Ser Gln Arg 
65                  70                  75                  80  


Phe Cys Asp Ser Gln Asp Ala Asp Leu Ala Gln Val Glu Ser Phe Gln 
                85                  90                  95      


Glu Leu Asn Phe Leu Leu Arg Tyr Lys Gly Pro Ser Asp His Trp Ile 
            100                 105                 110         


Gly Leu Ser Arg Glu Gln Gly Gln Pro Trp Lys Trp Ile Asn Gly Xaa 
        115                 120                 125             


Glu Trp Xaa Arg Gln Leu Val Met Lys Glu Asp Gly Ala Asn Leu Tyr 
    130                 135                 140                 


Val Ala Lys Val Ser Gln Val Pro Arg Met Asn Pro Arg Pro Val Met 
145                 150                 155                 160 


Val Ser Tyr Pro Gly Ser Arg Arg Val Cys Leu Phe Glu 
                165                 170             


<210> 6295
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<400> 6295
Glu His Ser Ile Lys Ala Xaa Leu Ile Trp Arg Leu Phe Phe Leu Ile 
1               5                   10                  15      


Met Phe Leu Xaa Ile Ile Val Cys Gly Met Val Ala Ala Leu Ser Ala 
            20                  25                  30          


Ile Arg Ala Asn Cys His Gln Glu Pro Ser Val Cys Leu Gln Ala Ala 
        35                  40                  45              


Cys Pro Glu Ser Trp Ile Gly Phe Gln Arg Lys Cys Phe Tyr Phe Ser 
    50                  55                  60                  


Asp Asp Xaa Lys Asn Trp Xaa Ser Ser Gln Arg Phe Cys Asp Ser Gln 
65                  70                  75                  80  


Asp Ala Asp Leu Ala Gln Val Glu Ser Phe Gln Glu Leu Val Ser Tyr 
                85                  90                  95      


Pro Gly Ser Arg Arg Val Cys Leu Phe Glu 
            100                 105     


<210> 6296
<211> 80
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<400> 6296
Met Phe Leu Xaa Ile Ile Val Cys Gly Met Val Ala Ala Leu Ser Ala 
1               5                   10                  15      


Ile Arg Ala Asn Cys His Gln Glu Pro Ser Val Cys Leu Gln Ala Ala 
            20                  25                  30          


Cys Pro Glu Ser Trp Ile Gly Phe Gln Arg Lys Cys Phe Tyr Phe Ser 
        35                  40                  45              


Asp Asp Xaa Lys Asn Trp Xaa Ser Ser Gln Arg Phe Cys Asp Ser Gln 
    50                  55                  60                  


Asp Ala Asp Leu Ala Gln Val Glu Ser Phe Gln Glu Leu Val Arg Lys 
65                  70                  75                  80  


<210> 6297
<211> 154
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<400> 6297
Met His Asp Ser Asn Asn Val Glu Lys Asp Ile Xaa Pro Ser Glu Leu 
1               5                   10                  15      


Pro Ala Asn Pro Ala Ile Arg Ala Asn Cys His Gln Glu Pro Ser Val 
            20                  25                  30          


Cys Leu Gln Ala Ala Cys Pro Glu Ser Trp Ile Gly Phe Gln Arg Lys 
        35                  40                  45              


Cys Phe Tyr Phe Ser Asp Asp Xaa Lys Asn Trp Xaa Ser Ser Gln Arg 
    50                  55                  60                  


Phe Cys Asp Ser Gln Asp Ala Asp Leu Ala Gln Val Glu Ser Phe Gln 
65                  70                  75                  80  


Glu Leu Asn Phe Leu Leu Arg Tyr Lys Gly Pro Ser Asp His Trp Ile 
                85                  90                  95      


Gly Leu Ser Arg Glu Gln Gly Gln Pro Trp Lys Trp Ile Asn Gly Xaa 
            100                 105                 110         


Glu Trp Xaa Arg Gln Phe Pro Ile Leu Gly Ala Gly Glu Cys Ala Tyr 
        115                 120                 125             


Leu Asn Asp Lys Gly Ala Ser Ser Ala Arg His Tyr Xaa Glu Arg Lys 
    130                 135                 140                 


Trp Ile Cys Ser Lys Ser Asp Ile His Val 
145                 150                 


<210> 6298
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<400> 6298
Met His Asp Ser Asn Asn Val Glu Lys Asp Ile Xaa Pro Ser Glu Leu 
1               5                   10                  15      


Pro Ala Asn Pro Ala Ile Arg Ala Asn Cys His Gln Glu Pro Ser Val 
            20                  25                  30          


Cys Leu Gln Ala Ala Cys Pro Glu Ser Trp Ile Gly Phe Gln Arg Lys 
        35                  40                  45              


Cys Phe Tyr Phe Ser Asp Asp Xaa Lys Asn Trp Xaa Ser Ser Gln Arg 
    50                  55                  60                  


Phe Cys Asp Ser Gln Asp Ala Asp Leu Ala Gln Val Glu Ser Phe Gln 
65                  70                  75                  80  


Glu Leu Val Ser Tyr Pro Gly Ser Arg Arg Val Cys Leu Phe Glu 
                85                  90                  95  


<210> 6299
<211> 154
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<400> 6299
Met His Asp Ser Asn Asn Val Glu Lys Asp Ile Xaa Pro Ser Glu Leu 
1               5                   10                  15      


Pro Ala Asn Pro Gly Cys Leu His Ser Lys Glu His Ser Ile Lys Ala 
            20                  25                  30          


Xaa Leu Ile Trp Arg Leu Phe Phe Leu Ile Met Phe Leu Xaa Ile Ile 
        35                  40                  45              


Val Cys Gly Met Val Ala Ala Leu Ser Ala Ile Arg Ala Asn Cys His 
    50                  55                  60                  


Gln Glu Pro Ser Val Cys Leu Gln Ala Ala Cys Pro Glu Ser Trp Ile 
65                  70                  75                  80  


Gly Phe Gln Arg Lys Cys Phe Tyr Phe Ser Asp Asp Xaa Lys Asn Trp 
                85                  90                  95      


Xaa Ser Ser Gln Arg Phe Cys Asp Ser Gln Asp Ala Asp Leu Ala Gln 
            100                 105                 110         


Val Glu Ser Phe Gln Glu Leu Asn Phe Leu Leu Arg Tyr Lys Gly Pro 
        115                 120                 125             


Ser Asp His Trp Ile Gly Leu Ser Arg Glu Gln Gly Gln Pro Trp Lys 
    130                 135                 140                 


Trp Ile Asn Gly Xaa Glu Trp Xaa Arg Gln 
145                 150                 


<210> 6300
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<400> 6300
Met His Asp Ser Asn Asn Val Glu Lys Asp Ile Xaa Pro Ser Glu Leu 
1               5                   10                  15      


Pro Ala Asn Pro Gly Cys Leu His Ser Lys Glu His Ser Ile Lys Ala 
            20                  25                  30          


Xaa Leu Ile Trp Arg Leu Phe Phe Leu Ile Met Phe Leu Xaa Ile Ile 
        35                  40                  45              


Val Cys Gly Met Val Ala Ala Leu Ser Ala Ile Arg Ala Asn Cys His 
    50                  55                  60                  


Gln Glu Pro Ser Val Cys Leu Gln Ala Ala Cys Pro Glu Ser Trp Ile 
65                  70                  75                  80  


Gly Phe Gln Arg Lys Cys Phe Tyr Phe Ser Asp Asp Xaa Lys Asn Trp 
                85                  90                  95      


Xaa Ser Ser Gln Arg Phe Cys Asp Ser Gln Asp Ala Asp Leu Ala Gln 
            100                 105                 110         


Val Glu Ser Phe Gln Glu Leu Asn Phe Leu Leu Arg Tyr Lys Gly Pro 
        115                 120                 125             


Ser Asp His Trp Ile Gly Leu Ser Arg Glu Gln Gly Gln Pro Trp Lys 
    130                 135                 140                 


Trp Ile Asn Gly Xaa Glu Trp Xaa Arg Gln Phe Pro Ile Leu Gly Ala 
145                 150                 155                 160 


Gly Glu Cys Ala Tyr Leu Asn Asp Lys Gly Ala Ser Ser Ala Arg His 
                165                 170                 175     


Tyr Xaa Glu Arg Lys Trp Ile Cys Ser Lys Ser Asp Ile His Val 
            180                 185                 190     


<210> 6301
<211> 194
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<400> 6301
Met His Asp Ser Asn Asn Val Glu Lys Asp Ile Xaa Pro Ser Glu Leu 
1               5                   10                  15      


Pro Ala Asn Pro Gly Cys Leu His Ser Lys Glu His Ser Ile Lys Ala 
            20                  25                  30          


Xaa Leu Ile Trp Arg Leu Phe Phe Leu Ile Met Phe Leu Xaa Ile Ile 
        35                  40                  45              


Val Cys Gly Met Val Ala Ala Leu Ser Ala Ile Arg Ala Asn Cys His 
    50                  55                  60                  


Gln Glu Pro Ser Val Cys Leu Gln Ala Ala Cys Pro Glu Ser Trp Ile 
65                  70                  75                  80  


Gly Phe Gln Arg Lys Cys Phe Tyr Phe Ser Asp Asp Xaa Lys Asn Trp 
                85                  90                  95      


Xaa Ser Ser Gln Arg Phe Cys Asp Ser Gln Asp Ala Asp Leu Ala Gln 
            100                 105                 110         


Val Glu Ser Phe Gln Glu Leu Asn Phe Leu Leu Arg Tyr Lys Gly Pro 
        115                 120                 125             


Ser Asp His Trp Ile Gly Leu Ser Arg Glu Gln Gly Gln Pro Trp Lys 
    130                 135                 140                 


Trp Ile Asn Gly Xaa Glu Trp Xaa Arg Gln Leu Val Met Lys Glu Asp 
145                 150                 155                 160 


Gly Ala Asn Leu Tyr Val Ala Lys Val Ser Gln Val Pro Arg Met Asn 
                165                 170                 175     


Pro Arg Pro Val Met Val Ser Tyr Pro Gly Ser Arg Arg Val Cys Leu 
            180                 185                 190         


Phe Glu 
        


<210> 6302
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<400> 6302
Met His Asp Ser Asn Asn Val Glu Lys Asp Ile Xaa Pro Ser Glu Leu 
1               5                   10                  15      


Pro Ala Asn Pro Gly Cys Leu His Ser Lys Glu His Ser Ile Lys Ala 
            20                  25                  30          


Xaa Leu Ile Trp Arg Leu Phe Phe Leu Ile Met Phe Leu Xaa Ile Ile 
        35                  40                  45              


Val Cys Gly Met Val Ala Ala Leu Ser Ala Ile Arg Ala Asn Cys His 
    50                  55                  60                  


Gln Glu Pro Ser Val Cys Leu Gln Ala Ala Cys Pro Glu Ser Trp Ile 
65                  70                  75                  80  


Gly Phe Gln Arg Lys Cys Phe Tyr Phe Ser Asp Asp Xaa Lys Asn Trp 
                85                  90                  95      


Xaa Ser Ser Gln Arg Phe Cys Asp Ser Gln Asp Ala Asp Leu Ala Gln 
            100                 105                 110         


Val Glu Ser Phe Gln Glu Leu Val Arg Lys 
        115                 120         


<210> 6303
<211> 132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<400> 6303
Met His Asp Ser Asn Asn Val Glu Lys Asp Ile Xaa Pro Ser Glu Leu 
1               5                   10                  15      


Pro Ala Asn Pro Gly Cys Leu His Ser Lys Glu His Ser Ile Lys Ala 
            20                  25                  30          


Xaa Leu Ile Trp Arg Leu Phe Phe Leu Ile Met Phe Leu Xaa Ile Ile 
        35                  40                  45              


Val Cys Gly Met Val Ala Ala Leu Ser Ala Ile Arg Ala Asn Cys His 
    50                  55                  60                  


Gln Glu Pro Ser Val Cys Leu Gln Ala Ala Cys Pro Glu Ser Trp Ile 
65                  70                  75                  80  


Gly Phe Gln Arg Lys Cys Phe Tyr Phe Ser Asp Asp Xaa Lys Asn Trp 
                85                  90                  95      


Xaa Ser Ser Gln Arg Phe Cys Asp Ser Gln Asp Ala Asp Leu Ala Gln 
            100                 105                 110         


Val Glu Ser Phe Gln Glu Leu Val Ser Tyr Pro Gly Ser Arg Arg Val 
        115                 120                 125             


Cys Leu Phe Glu 
    130         


<210> 6304
<211> 54
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<400> 6304
Met His Asp Ser Asn Asn Val Glu Lys Asp Ile Xaa Pro Ser Glu Leu 
1               5                   10                  15      


Pro Ala Asn Pro Gly Xaa Ser Val Ser Cys Cys His Val Lys Lys Asn 
            20                  25                  30          


Xaa Phe Ala Ser Ser Ser Xaa Ile Ile Val Val Cys Ile Gln Lys Ser 
        35                  40                  45              


Ile Leu Leu Lys Leu Pro 
    50                  


<210> 6305
<211> 140
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<400> 6305
Val Glu Lys Asp Ile Xaa Pro Ser Glu Leu Pro Ala Asn Pro Ala Ile 
1               5                   10                  15      


Arg Ala Asn Cys His Gln Glu Pro Ser Val Cys Leu Gln Ala Ala Cys 
            20                  25                  30          


Pro Glu Ser Trp Ile Gly Phe Gln Arg Lys Cys Phe Tyr Phe Ser Asp 
        35                  40                  45              


Asp Xaa Lys Asn Trp Xaa Ser Ser Gln Arg Phe Cys Asp Ser Gln Asp 
    50                  55                  60                  


Ala Asp Leu Ala Gln Val Glu Ser Phe Gln Glu Leu Asn Phe Leu Leu 
65                  70                  75                  80  


Arg Tyr Lys Gly Pro Ser Asp His Trp Ile Gly Leu Ser Arg Glu Gln 
                85                  90                  95      


Gly Gln Pro Trp Lys Trp Ile Asn Gly Xaa Glu Trp Xaa Arg Gln Leu 
            100                 105                 110         


Val Met Lys Glu Asp Gly Ala Asn Leu Tyr Val Ala Lys Val Ser Gln 
        115                 120                 125             


Val Pro Arg Met Asn Pro Arg Pro Val Met Val Arg 
    130                 135                 140 


<210> 6306
<211> 84
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 6306
Phe Lys Asn Glu Phe Lys Ser Ser Gly Ile Asn Xaa Ala Ser Ser Ala 
1               5                   10                  15      


Ala Ser Lys Glu Arg Xaa Ala Pro His Lys Ser Asn Xaa Gly Phe Pro 
            20                  25                  30          


Lys Leu Leu Cys Ala Ser Leu Leu Ile Phe Phe Leu Leu Leu Ala Ile 
        35                  40                  45              


Ser Phe Phe Ile Ala Phe Val Arg Phe His Leu Pro Glu Ser Ala Arg 
    50                  55                  60                  


Arg Ile Cys Leu Phe Cys Gly Ala Leu Arg Ser Arg Arg Ser Ala Xaa 
65                  70                  75                  80  


Leu Ala Met Gly 
                


<210> 6307
<211> 237
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<400> 6307
Met Xaa Ser Glu Ile Xaa Tyr Ala Glu Val Arg Phe Lys Asn Glu Phe 
1               5                   10                  15      


Lys Ser Ser Gly Ile Asn Xaa Ala Ser Ser Ala Ala Ser Lys Glu Arg 
            20                  25                  30          


Xaa Ala Pro His Lys Ser Asn Xaa Gly Phe Pro Lys Leu Leu Cys Ala 
        35                  40                  45              


Ser Leu Leu Ile Phe Phe Leu Leu Leu Ala Ile Ser Phe Phe Ile Ala 
    50                  55                  60                  


Phe Val Ile Phe Phe Gln Lys Tyr Ser Gln Leu Leu Glu Lys Lys Xaa 
65                  70                  75                  80  


Xaa Lys Glu Leu Val His Xaa Xaa Leu Glu Cys Val Lys Lys Asn Met 
                85                  90                  95      


Pro Val Glu Glu Xaa Ala Trp Ser Cys Cys Pro Lys Asn Trp Lys Ser 
            100                 105                 110         


Phe Ser Ser Asn Cys Tyr Phe Ile Ser Xaa Glu Ser Ala Ser Trp Gln 
        115                 120                 125             


Asp Ser Glu Lys Asp Cys Ala Arg Met Glu Ala His Leu Leu Val Ile 
    130                 135                 140                 


Asn Xaa Gln Glu Glu Gln Asp Phe Ile Phe Gln Asn Leu Gln Glu Glu 
145                 150                 155                 160 


Ser Ala Tyr Phe Val Gly Leu Ser Asp Pro Glu Gly Gln Arg His Trp 
                165                 170                 175     


Gln Trp Val Asp Gln Xaa Pro Tyr Asn Glu Ser Ser Xaa Phe Trp His 
            180                 185                 190         


Pro Arg Glu Pro Ser Asp Pro Asn Glu Arg Cys Val Val Leu Asn Phe 
        195                 200                 205             


Arg Lys Ser Pro Lys Arg Trp Gly Trp Asn Asp Val Asn Cys Leu Gly 
    210                 215                 220                 


Pro Gln Arg Ser Val Cys Glu Met Met Lys Ile His Leu 
225                 230                 235         


<210> 6308
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<400> 6308
Met Xaa Ser Glu Ile Xaa Tyr Ala Glu Val Arg Phe Lys Asn Glu Phe 
1               5                   10                  15      


Lys Ser Ser Gly Ile Asn Xaa Ala Ser Ser Ala Ala Ser Lys Glu Arg 
            20                  25                  30          


Xaa Ala Pro His Lys Ser Asn Xaa Gly Phe Pro Lys Leu Leu Cys Ala 
        35                  40                  45              


Ser Leu Leu Ile Phe Phe Leu Leu Leu Ala Ile Ser Phe Phe Ile Ala 
    50                  55                  60                  


Phe Val Lys Xaa Ala Trp Ser Cys Cys Pro Lys Asn Trp Lys Ser Phe 
65                  70                  75                  80  


Ser Ser Asn Cys Tyr Phe Ile Ser Xaa Glu Ser Ala Ser Trp Gln Asp 
                85                  90                  95      


Ser Glu Lys Asp Cys Ala Arg Met Glu Ala His Leu Leu Val Ile Asn 
            100                 105                 110         


Xaa Gln Glu Glu Gln Asp Phe Ile Phe Gln Asn Leu Gln Glu Glu Ser 
        115                 120                 125             


Ala Tyr Phe Val Gly Leu Ser Asp Pro Glu Gly Gln Arg His Trp Gln 
    130                 135                 140                 


Trp Val Asp Gln Xaa Pro Tyr Asn Glu Ser Ser Xaa Phe Trp His Pro 
145                 150                 155                 160 


Arg Glu Pro Ser Asp Pro Asn Glu Arg Cys Val Val Leu Asn Phe Arg 
                165                 170                 175     


Lys Ser Pro Lys Arg Trp Gly Trp Asn Asp Val Asn Cys Leu Gly Pro 
            180                 185                 190         


Gln Arg Ser Val Cys Glu Met Met Lys Ile His Leu 
        195                 200                 


<210> 6309
<211> 165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 6309
Met Xaa Ser Glu Ile Xaa Tyr Ala Glu Val Arg Phe Lys Asn Glu Phe 
1               5                   10                  15      


Lys Ser Ser Gly Ile Asn Xaa Ala Ser Ser Ala Glu Xaa Ala Trp Ser 
            20                  25                  30          


Cys Cys Pro Lys Asn Trp Lys Ser Phe Ser Ser Asn Cys Tyr Phe Ile 
        35                  40                  45              


Ser Xaa Glu Ser Ala Ser Trp Gln Asp Ser Glu Lys Asp Cys Ala Arg 
    50                  55                  60                  


Met Glu Ala His Leu Leu Val Ile Asn Xaa Gln Glu Glu Gln Asp Phe 
65                  70                  75                  80  


Ile Phe Gln Asn Leu Gln Glu Glu Ser Ala Tyr Phe Val Gly Leu Ser 
                85                  90                  95      


Asp Pro Glu Gly Gln Arg His Trp Gln Trp Val Asp Gln Xaa Pro Tyr 
            100                 105                 110         


Asn Glu Ser Ser Xaa Phe Trp His Pro Arg Glu Pro Ser Asp Pro Asn 
        115                 120                 125             


Glu Arg Cys Val Val Leu Asn Phe Arg Lys Ser Pro Lys Arg Trp Gly 
    130                 135                 140                 


Trp Asn Asp Val Asn Cys Leu Gly Pro Gln Arg Ser Val Cys Glu Met 
145                 150                 155                 160 


Met Lys Ile His Leu 
                165 


<210> 6310
<211> 198
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 6310
Met Xaa Ser Glu Ile Xaa Tyr Ala Glu Val Arg Phe Lys Asn Glu Phe 
1               5                   10                  15      


Lys Ser Ser Gly Ile Asn Xaa Ala Ser Ser Ala Val Phe Phe Gln Lys 
            20                  25                  30          


Tyr Ser Gln Leu Leu Glu Lys Lys Xaa Xaa Lys Glu Leu Val His Xaa 
        35                  40                  45              


Xaa Leu Glu Cys Val Lys Lys Asn Met Pro Val Glu Glu Xaa Ala Trp 
    50                  55                  60                  


Ser Cys Cys Pro Lys Asn Trp Lys Ser Phe Ser Ser Asn Cys Tyr Phe 
65                  70                  75                  80  


Ile Ser Xaa Glu Ser Ala Ser Trp Gln Asp Ser Glu Lys Asp Cys Ala 
                85                  90                  95      


Arg Met Glu Ala His Leu Leu Val Ile Asn Xaa Gln Glu Glu Gln Asp 
            100                 105                 110         


Phe Ile Phe Gln Asn Leu Gln Glu Glu Ser Ala Tyr Phe Val Gly Leu 
        115                 120                 125             


Ser Asp Pro Glu Gly Gln Arg His Trp Gln Trp Val Asp Gln Xaa Pro 
    130                 135                 140                 


Tyr Asn Glu Ser Ser Xaa Phe Trp His Pro Arg Glu Pro Ser Asp Pro 
145                 150                 155                 160 


Asn Glu Arg Cys Val Val Leu Asn Phe Arg Lys Ser Pro Lys Arg Trp 
                165                 170                 175     


Gly Trp Asn Asp Val Asn Cys Leu Gly Pro Gln Arg Ser Val Cys Glu 
            180                 185                 190         


Met Met Lys Ile His Leu 
        195             


<210> 6311
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 6311
Asp Trp Ser Cys Cys Pro Xaa Pro Trp Xaa Ser Phe Gln Ser Ser Cys 
1               5                   10                  15      


Tyr Phe Ile Ser Xaa Gly Met Gln Ser Trp Xaa Lys Ser Gln Lys Asn 
            20                  25                  30          


Cys Ser Val Met Gly Ala Asp Leu Val Val Ile Asn Xaa Arg Glu Glu 
        35                  40                  45              


Gln Asp Phe Ile Ile Gln Asn Leu Lys Arg Asn Ser Ser Tyr Phe Leu 
    50                  55                  60                  


Gly Leu Ser Asp Pro Gly Gly Arg Arg His Trp Gln Trp Val Asp Gln 
65                  70                  75                  80  


Xaa Pro Tyr Asn Glu Asn Val Xaa 
                85              


<210> 6312
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<400> 6312
Glu Glu Glu Pro Gln Asp Arg Glu Lys Gly Leu Trp Trp Phe Gln Leu 
1               5                   10                  15      


Lys Val Trp Ser Met Ala Val Val Ser Ile Leu Leu Leu Ser Val Cys 
            20                  25                  30          


Phe Xaa Val Ser Ser Val Asp Trp Ser Cys Cys Pro Xaa Pro Trp Xaa 
        35                  40                  45              


Ser Phe Gln Ser Ser Cys Tyr Phe Ile Ser Xaa Gly Met Gln Ser Trp 
    50                  55                  60                  


Xaa Lys Ser Gln Lys Asn Cys Ser Val Met Gly Ala Asp Leu Val Val 
65                  70                  75                  80  


Ile Asn Xaa Arg Glu Glu Gln Asp Phe Ile Ile Gln Asn Leu Lys Arg 
                85                  90                  95      


Asn Ser Ser Tyr Phe Leu Gly Leu Ser Asp Pro Gly Gly Arg Arg His 
            100                 105                 110         


Trp Gln Trp Val Asp Gln Xaa Pro Tyr Asn Glu Asn Val Xaa Phe Trp 
        115                 120                 125             


His Ser Gly Glu Pro Asn Asn Leu Asp Glu 
    130                 135             


<210> 6313
<211> 213
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 6313
Met Val Pro Glu Glu Glu Pro Gln Asp Arg Glu Lys Gly Leu Trp Trp 
1               5                   10                  15      


Phe Gln Leu Lys Val Trp Ser Met Ala Val Val Ser Ile Leu Leu Leu 
            20                  25                  30          


Ser Val Cys Phe Xaa Val Ser Ser Val Val Pro His Asn Phe Met Tyr 
        35                  40                  45              


Ser Lys Xaa Val Lys Arg Leu Ser Lys Leu Arg Glu Tyr Gln Gln Tyr 
    50                  55                  60                  


His Pro Ser Leu Xaa Cys Val Met Glu Gly Lys Asp Ile Glu Asp Trp 
65                  70                  75                  80  


Ser Cys Cys Pro Xaa Pro Trp Xaa Ser Phe Gln Ser Ser Cys Tyr Phe 
                85                  90                  95      


Ile Ser Xaa Gly Met Gln Ser Trp Xaa Lys Ser Gln Lys Asn Cys Ser 
            100                 105                 110         


Val Met Gly Ala Asp Leu Val Val Ile Asn Xaa Arg Glu Glu Gln Asp 
        115                 120                 125             


Phe Ile Ile Gln Asn Leu Lys Arg Asn Ser Ser Tyr Phe Leu Gly Leu 
    130                 135                 140                 


Ser Asp Pro Gly Gly Arg Arg His Trp Gln Trp Val Asp Gln Xaa Pro 
145                 150                 155                 160 


Tyr Asn Glu Asn Val Xaa Phe Trp His Ser Gly Glu Pro Asn Asn Leu 
                165                 170                 175     


Asp Glu Arg Cys Ala Ile Ile Asn Phe Arg Ser Ser Glu Glu Trp Gly 
            180                 185                 190         


Trp Asn Asp Ile His Cys His Val Pro Gln Lys Ser Ile Cys Lys Met 
        195                 200                 205             


Lys Lys Ile Tyr Ile 
    210             


<210> 6314
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<400> 6314
Met Val Pro Glu Glu Glu Pro Gln Asp Arg Val Pro His Asn Phe Met 
1               5                   10                  15      


Tyr Ser Lys Xaa Val Lys Arg Leu Ser Lys Leu Arg Glu Tyr Gln Gln 
            20                  25                  30          


Tyr His Pro Ser Leu Xaa Cys Val Met Glu Gly Lys Asp Ile Glu Asp 
        35                  40                  45              


Trp Ser Cys Cys Pro Xaa Pro Trp Xaa Ser Phe Gln Ser Ser Cys Tyr 
    50                  55                  60                  


Phe Ile Ser Xaa Gly Met Gln Ser Trp Xaa Lys Ser Gln Lys Asn Cys 
65                  70                  75                  80  


Ser Val Met Gly Ala Asp Leu Val Val Ile Asn Xaa Arg Glu Glu Gln 
                85                  90                  95      


Asp Phe Ile Ile Gln Asn Leu Lys Arg Asn Ser Ser Tyr Phe Leu Gly 
            100                 105                 110         


Leu Ser Asp Pro Gly Gly Arg Arg His Trp Gln Trp Val Asp Gln Xaa 
        115                 120                 125             


Pro Tyr Asn Glu Asn Val Xaa Phe Trp His Ser Gly Glu Pro Asn Asn 
    130                 135                 140                 


Leu Asp Glu Arg Cys Ala Ile Ile Asn Phe Arg Ser Ser Glu Glu Trp 
145                 150                 155                 160 


Gly Trp Asn Asp Ile His Cys His Val Pro Gln Lys Ser Ile Cys Lys 
                165                 170                 175     


Met Lys Lys Ile Tyr Ile 
            180         


<210> 6315
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<400> 6315
Met Gly Leu Glu Lys Pro Gln Ser Lys Leu Glu Gly Gly Met His Pro 
1               5                   10                  15      


Gln Leu Ile Pro Ser Val Ile Ala Val Val Phe Ile Leu Leu Leu Ser 
            20                  25                  30          


Val Cys Phe Ile Ala Ser Cys Leu Val Xaa His His Asn Phe Ser Arg 
        35                  40                  45              


Cys Lys Arg Gly Xaa Gly Val His Lys Leu Glu His His Ala Lys Leu 
    50                  55                  60                  


Lys Cys Ile Lys Glu Lys Ser Glu Leu Lys Ser Ala Glu Gly Ser Xaa 
65                  70                  75                  80  


Trp Asn Cys Cys Pro Ile Asp Trp Arg Ala Phe Gln Ser Asn Cys Tyr 
                85                  90                  95      


Phe Pro Leu Xaa Asp Asn Lys Xaa Trp Ala Glu Ser Glu Arg Asn Cys 
            100                 105                 110         


Ser Gly Met Gly Ala His Leu Met Xaa Ile Ser Xaa Glu Ala Glu Gln 
        115                 120                 125             


Asn Phe Ile Ile Gln Phe Leu Asp Arg Arg Leu Ser Tyr Phe Leu Gly 
    130                 135                 140                 


<210> 6316
<211> 215
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(213)
<223> Selenocysteine

<400> 6316
Met Gly Leu Glu Lys Pro Gln Ser Lys Leu Glu Gly Gly Met His Pro 
1               5                   10                  15      


Gln Leu Ile Pro Ser Val Ile Ala Val Val Phe Ile Leu Leu Leu Ser 
            20                  25                  30          


Val Cys Phe Ile Ala Ser Cys Leu Val Xaa His His Asn Phe Ser Arg 
        35                  40                  45              


Cys Lys Arg Gly Xaa Gly Val His Lys Leu Glu His His Ala Lys Leu 
    50                  55                  60                  


Lys Cys Ile Lys Glu Lys Ser Glu Leu Lys Ser Ala Glu Gly Ser Xaa 
65                  70                  75                  80  


Trp Asn Cys Cys Pro Ile Asp Trp Arg Ala Phe Gln Ser Asn Cys Tyr 
                85                  90                  95      


Phe Pro Leu Xaa Asp Asn Lys Xaa Trp Ala Glu Ser Glu Arg Asn Cys 
            100                 105                 110         


Ser Gly Met Gly Ala His Leu Met Xaa Ile Ser Xaa Glu Ala Glu Gln 
        115                 120                 125             


Asn Phe Ile Ile Gln Phe Leu Asp Arg Arg Leu Ser Tyr Phe Leu Gly 
    130                 135                 140                 


Leu Arg Asp Glu Asn Ala Lys Gly Gln Trp Arg Trp Val Asp Gln Xaa 
145                 150                 155                 160 


Pro Phe Asn Pro Arg Arg Val Phe Trp His Lys Asn Glu Pro Asp Asn 
                165                 170                 175     


Ser Gln Gly Glu Asn Cys Val Val Leu Val Tyr Asn Gln Asp Lys Trp 
            180                 185                 190         


Ala Trp Asn Asp Val Pro Cys Asn Phe Glu Ala Ser Arg Ile Cys Lys 
        195                 200                 205             


Ile Pro Gly Xaa Xaa Leu Asn 
    210                 215 


<210> 6317
<211> 174
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<400> 6317
Met Asn Ser Ser Lys Ser Ser Glu Xaa Gln Cys Xaa Glu Arg Gly Cys 
1               5                   10                  15      


Phe Ser Ser Gln Met Phe Leu Trp Xaa Val Ala Gly Ile Pro Ile Leu 
            20                  25                  30          


Phe Leu Ser Ala Cys Phe Ile Xaa Arg Cys Val Val Xaa Phe Arg Ile 
        35                  40                  45              


Phe Gln Xaa Cys Asp Glu Lys Lys Phe Gln Leu Pro Glu Asn Phe Xaa 
    50                  55                  60                  


Glu Leu Ser Cys Tyr Asn Tyr Gly Ser Gly Ile Ile Val Pro Lys Glu 
65                  70                  75                  80  


Phe Leu Ser Tyr Lys Lys Pro Lys Met Arg Glu Phe Phe Ile Gly Leu 
                85                  90                  95      


Ser Asp Gln Val Val Glu Gly Gln Trp Gln Trp Val Asp Gly Xaa Pro 
            100                 105                 110         


Leu Xaa Lys Ser Leu Ser Phe Trp Asp Val Gly Glu Pro Asn Asn Ile 
        115                 120                 125             


Ala Xaa Leu Glu Asp Cys Ala Xaa Met Arg Asp Ser Ser Asn Pro Arg 
    130                 135                 140                 


Gln Asn Trp Asn Asp Val Xaa Cys Phe Leu Asn Tyr Phe Arg Ile Cys 
145                 150                 155                 160 


Glu Met Val Gly Ile Asn Pro Leu Asn Lys Gly Lys Ser Leu 
                165                 170                 


<210> 6318
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 6318
Met Asn Ser Ser Lys Ser Ser Glu Xaa Gln Cys Xaa Glu Arg Gly Cys 
1               5                   10                  15      


Phe Ser Ser Gln Met Phe Leu Trp Xaa Val Ala Gly Ile Pro Ile Leu 
            20                  25                  30          


Phe Leu Ser Ala Cys Phe Ile Xaa Arg Cys Val Val Xaa Phe Arg Ile 
        35                  40                  45              


Phe Gln Xaa Cys Asp Glu Lys Lys Phe Gln Leu Pro Glu Asn Phe Xaa 
    50                  55                  60                  


Glu Leu Ser Cys Tyr Asn Tyr Gly Ser Gly Ile Ile Val Pro Lys Val 
65                  70                  75                  80  


Asn Ile Lys Ile Tyr Lys Ala Xaa Phe Ser Gly Phe 
                85                  90          


<210> 6319
<211> 219
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<400> 6319
Met Asn Ser Ser Lys Ser Ser Glu Xaa Gln Cys Xaa Glu Arg Gly Cys 
1               5                   10                  15      


Phe Ser Ser Gln Met Phe Leu Trp Xaa Val Ala Gly Ile Pro Ile Leu 
            20                  25                  30          


Phe Leu Ser Ala Cys Phe Ile Xaa Arg Cys Val Val Xaa Phe Arg Ile 
        35                  40                  45              


Phe Gln Xaa Cys Asp Glu Lys Lys Phe Gln Leu Pro Glu Asn Phe Xaa 
    50                  55                  60                  


Glu Leu Ser Cys Tyr Asn Tyr Gly Ser Gly Ser Val Lys Asn Cys Cys 
65                  70                  75                  80  


Pro Leu Asn Trp Glu Tyr Phe Gln Ser Ser Cys Tyr Phe Phe Ser Xaa 
                85                  90                  95      


Asp Xaa Ile Ser Trp Ala Leu Ser Leu Lys Asn Cys Ser Ala Met Gly 
            100                 105                 110         


Ala His Leu Val Val Ile Asn Ser Gln Glu Glu Gln Glu Phe Leu Ser 
        115                 120                 125             


Tyr Lys Lys Pro Lys Met Arg Glu Phe Phe Ile Gly Leu Ser Asp Gln 
    130                 135                 140                 


Val Val Glu Gly Gln Trp Gln Trp Val Asp Gly Xaa Pro Leu Xaa Lys 
145                 150                 155                 160 


Ser Leu Ser Phe Trp Asp Val Gly Glu Pro Asn Asn Ile Ala Xaa Leu 
                165                 170                 175     


Glu Asp Cys Ala Xaa Met Arg Asp Ser Ser Asn Pro Arg Gln Asn Trp 
            180                 185                 190         


Asn Asp Val Xaa Cys Phe Leu Asn Tyr Phe Arg Ile Cys Glu Met Val 
        195                 200                 205             


Gly Ile Asn Pro Leu Asn Lys Gly Lys Ser Leu 
    210                 215                 


<210> 6320
<211> 94
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<400> 6320
Xaa Asn Phe Xaa Glu Leu Ser Cys Tyr Asn Tyr Gly Ser Gly Ser Val 
1               5                   10                  15      


Lys Asn Cys Cys Pro Leu Asn Trp Glu Tyr Phe Gln Ser Ser Cys Tyr 
            20                  25                  30          


Phe Phe Ser Xaa Asp Xaa Ile Ser Trp Ala Leu Ser Leu Lys Asn Cys 
        35                  40                  45              


Ser Ala Met Gly Ala His Leu Val Val Ile Asn Ser Gln Glu Glu Gln 
    50                  55                  60                  


Leu Leu Gly Cys Arg Gly Ala Gln Gln His Ser Tyr Pro Gly Gly Leu 
65                  70                  75                  80  


Cys His His Glu Arg Leu Phe Lys Pro Lys Ala Lys Leu Glu 
                85                  90                  


<210> 6321
<211> 387
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<400> 6321
Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Xaa Xaa Asn Phe Gln Phe Gln Gln Ile His Gly His Lys 
            20                  25                  30          


Ser Ser Xaa Gly Cys Leu Gly His Gly Ala Leu Val Leu Gln Leu Leu 
        35                  40                  45              


Ser Phe Met Leu Leu Ala Gly Val Leu Pro Arg Leu Ser Lys Val Pro 
    50                  55                  60                  


Ser Ser Leu Ser Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn 
65                  70                  75                  80  


Leu Xaa Gln Leu Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys 
                85                  90                  95      


Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Gln Leu Lys Ala Ala Val Gly 
            100                 105                 110         


Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa 
        115                 120                 125             


Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
    130                 135                 140                 


Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu 
145                 150                 155                 160 


Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu 
                165                 170                 175     


Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile 
            180                 185                 190         


Tyr Gln Glu Leu Xaa Glu Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        195                 200                 205             


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Gln Leu Lys Ala 
    210                 215                 220                 


Ala Val Gly Glu Leu Pro Asp Gln Ser Lys Gln Gln Gln Ile Tyr Gln 
225                 230                 235                 240 


Glu Leu Xaa Asp Leu Lys Xaa Ala Phe Glu Arg Leu Cys Arg His Cys 
                245                 250                 255     


Pro Lys Asp Trp Xaa Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn 
            260                 265                 270         


Ser Gln Arg Asn Trp His Asp Ser Val Xaa Ala Cys Gln Glu Val Arg 
        275                 280                 285             


Ala Gln Leu Val Val Ile Lys Xaa Ala Glu Glu Gln Asn Phe Leu Gln 
    290                 295                 300                 


Leu Gln Xaa Ser Arg Ser Asn Arg Phe Ser Trp Met Gly Leu Ser Asp 
305                 310                 315                 320 


Leu Asn Gln Glu Gly Xaa Trp Gln Trp Val Asp Gly Ser Pro Leu Ser 
                325                 330                 335     


Pro Ser Phe Gln Arg Tyr Trp Asn Ser Gly Glu Pro Asn Asn Ser Gly 
            340                 345                 350         


Asn Glu Asp Cys Ala Glu Phe Ser Gly Ser Gly Trp Asn Asp Asn Arg 
        355                 360                 365             


Cys Asp Val Asp Asn Tyr Trp Ile Cys Lys Lys Pro Ala Ala Cys Phe 
    370                 375                 380                 


Arg Asp Glu 
385         


<210> 6322
<211> 232
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<400> 6322
Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Xaa Xaa Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Xaa Gly Cys Leu Gly His 
        35                  40                  45              


Gly Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu Leu Ala Gly Val 
    50                  55                  60                  


Leu Val Ala Ile Leu Val Gln Val Ser Lys Val Pro Ser Ser Leu Ser 
65                  70                  75                  80  


Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn Leu Xaa Gln Leu 
                85                  90                  95      


Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile 
            100                 105                 110         


Tyr Gln Glu Leu Xaa Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        115                 120                 125             


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala 
    130                 135                 140                 


Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln 
145                 150                 155                 160 


Glu Leu Xaa Arg Leu Lys Ala Ala Val Glu Arg Leu Cys Arg His Cys 
                165                 170                 175     


Pro Lys Asp Trp Xaa Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn 
            180                 185                 190         


Ser Gln Arg Asn Trp His Asp Ser Val Xaa Ala Cys Gln Glu Val Arg 
        195                 200                 205             


Ala Gln Leu Val Val Ile Lys Xaa Ala Glu Glu Gln Leu Pro Ala Val 
    210                 215                 220                 


Leu Glu Gln Trp Arg Xaa Gln Gln 
225                 230         


<210> 6323
<211> 376
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<400> 6323
Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Xaa Xaa Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Xaa Gly Cys Leu Gly His 
        35                  40                  45              


Gly Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu Leu Ala Gly Val 
    50                  55                  60                  


Leu Val Ala Ile Leu Val Gln Val Ser Lys Val Pro Ser Ser Leu Ser 
65                  70                  75                  80  


Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn Leu Xaa Gln Leu 
                85                  90                  95      


Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile 
            100                 105                 110         


Tyr Gln Glu Leu Xaa Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        115                 120                 125             


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala 
    130                 135                 140                 


Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln 
145                 150                 155                 160 


Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser 
                165                 170                 175     


Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Glu Leu Lys Ala Ala Val 
            180                 185                 190         


Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu 
        195                 200                 205             


Xaa Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Asp Gln Ser Lys Gln 
    210                 215                 220                 


Gln Gln Ile Tyr Gln Glu Leu Xaa Asp Leu Lys Xaa Ala Phe Glu Arg 
225                 230                 235                 240 


Leu Cys Arg His Cys Pro Lys Asp Trp Xaa Phe Phe Gln Gly Asn Cys 
                245                 250                 255     


Tyr Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp Ser Val Xaa Ala 
            260                 265                 270         


Cys Gln Glu Val Arg Ala Gln Leu Val Val Ile Lys Xaa Ala Glu Glu 
        275                 280                 285             


Gln Asn Phe Leu Gln Leu Gln Xaa Ser Arg Ser Asn Arg Phe Ser Trp 
    290                 295                 300                 


Met Gly Leu Ser Asp Leu Asn Gln Glu Gly Xaa Trp Gln Trp Val Asp 
305                 310                 315                 320 


Gly Ser Pro Leu Ser Pro Ser Phe Gln Arg Tyr Trp Asn Ser Gly Glu 
                325                 330                 335     


Pro Asn Asn Ser Gly Asn Glu Asp Cys Ala Glu Phe Ser Gly Ser Gly 
            340                 345                 350         


Trp Asn Asp Asn Arg Cys Asp Val Asp Asn Tyr Trp Ile Cys Lys Lys 
        355                 360                 365             


Pro Ala Ala Cys Phe Arg Asp Glu 
    370                 375     


<210> 6324
<211> 399
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<400> 6324
Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Xaa Xaa Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Xaa Gly Cys Leu Gly His 
        35                  40                  45              


Gly Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu Leu Ala Gly Val 
    50                  55                  60                  


Leu Val Ala Ile Leu Val Gln Val Ser Lys Val Pro Ser Ser Leu Ser 
65                  70                  75                  80  


Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn Leu Xaa Gln Leu 
                85                  90                  95      


Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile 
            100                 105                 110         


Tyr Gln Glu Leu Xaa Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        115                 120                 125             


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala 
    130                 135                 140                 


Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln 
145                 150                 155                 160 


Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser 
                165                 170                 175     


Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val 
            180                 185                 190         


Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu 
        195                 200                 205             


Xaa Glu Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu 
    210                 215                 220                 


Gln Glu Ile Tyr Gln Glu Leu Xaa Gln Leu Lys Ala Ala Val Gly Glu 
225                 230                 235                 240 


Leu Pro Asp Gln Ser Lys Gln Gln Gln Ile Tyr Gln Glu Leu Xaa Asp 
                245                 250                 255     


Leu Lys Xaa Ala Phe Glu Arg Leu Cys Arg His Cys Pro Lys Asp Trp 
            260                 265                 270         


Xaa Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn Ser Gln Arg Asn 
        275                 280                 285             


Trp His Asp Ser Val Xaa Ala Cys Gln Glu Val Arg Ala Gln Leu Val 
    290                 295                 300                 


Val Ile Lys Xaa Ala Glu Glu Gln Asn Phe Leu Gln Leu Gln Xaa Ser 
305                 310                 315                 320 


Arg Ser Asn Arg Phe Ser Trp Met Gly Leu Ser Asp Leu Asn Gln Glu 
                325                 330                 335     


Gly Xaa Trp Gln Trp Val Asp Gly Ser Pro Leu Ser Pro Ser Phe Gln 
            340                 345                 350         


Arg Tyr Trp Asn Ser Gly Glu Pro Asn Asn Ser Gly Asn Glu Asp Cys 
        355                 360                 365             


Ala Glu Phe Ser Gly Ser Gly Trp Asn Asp Asn Arg Cys Asp Val Asp 
    370                 375                 380                 


Asn Tyr Trp Ile Cys Lys Lys Pro Ala Ala Cys Phe Arg Asp Glu 
385                 390                 395                 


<210> 6325
<211> 263
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<400> 6325
Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Xaa Xaa Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Xaa Val Pro Phe Leu Leu 
        35                  40                  45              


Gly Pro Val Ser Lys Val Pro Ser Ser Leu Ser Gln Glu Gln Ser Glu 
    50                  55                  60                  


Gln Asp Ala Ile Tyr Gln Asn Leu Xaa Gln Leu Lys Ala Ala Val Gly 
65                  70                  75                  80  


Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa 
                85                  90                  95      


Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
            100                 105                 110         


Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Glu Arg Leu 
        115                 120                 125             


Cys Arg His Cys Pro Lys Asp Trp Xaa Phe Phe Gln Gly Asn Cys Tyr 
    130                 135                 140                 


Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp Ser Val Xaa Ala Cys 
145                 150                 155                 160 


Gln Glu Val Arg Ala Gln Leu Val Val Ile Lys Xaa Ala Glu Glu Gln 
                165                 170                 175     


Asn Phe Leu Gln Leu Gln Xaa Ser Arg Ser Asn Arg Phe Ser Trp Met 
            180                 185                 190         


Gly Leu Ser Asp Leu Asn Gln Glu Gly Xaa Trp Gln Trp Val Asp Gly 
        195                 200                 205             


Ser Pro Leu Ser Pro Ser Phe Gln Arg Tyr Trp Asn Ser Gly Glu Pro 
    210                 215                 220                 


Asn Asn Ser Gly Asn Glu Asp Cys Ala Glu Phe Ser Gly Ser Gly Trp 
225                 230                 235                 240 


Asn Asp Asn Arg Cys Asp Val Asp Asn Tyr Trp Ile Cys Lys Lys Pro 
                245                 250                 255     


Ala Ala Cys Phe Arg Asp Glu 
            260             


<210> 6326
<211> 332
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<400> 6326
Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Xaa Xaa Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Xaa Val Pro Phe Leu Leu 
        35                  40                  45              


Gly Pro Val Ser Lys Val Pro Ser Ser Leu Ser Gln Glu Gln Ser Glu 
    50                  55                  60                  


Gln Asp Ala Ile Tyr Gln Asn Leu Xaa Gln Leu Lys Ala Ala Val Gly 
65                  70                  75                  80  


Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa 
                85                  90                  95      


Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
            100                 105                 110         


Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu 
        115                 120                 125             


Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu 
    130                 135                 140                 


Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile 
145                 150                 155                 160 


Tyr Gln Glu Leu Xaa Glu Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
                165                 170                 175     


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Gln Leu Lys Ala 
            180                 185                 190         


Ala Val Glu Arg Leu Cys Arg His Cys Pro Lys Asp Trp Xaa Phe Phe 
        195                 200                 205             


Gln Gly Asn Cys Tyr Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp 
    210                 215                 220                 


Ser Val Xaa Ala Cys Gln Glu Val Arg Ala Gln Leu Val Val Ile Lys 
225                 230                 235                 240 


Xaa Ala Glu Glu Gln Asn Phe Leu Gln Leu Gln Xaa Ser Arg Ser Asn 
                245                 250                 255     


Arg Phe Ser Trp Met Gly Leu Ser Asp Leu Asn Gln Glu Gly Xaa Trp 
            260                 265                 270         


Gln Trp Val Asp Gly Ser Pro Leu Ser Pro Ser Phe Gln Arg Tyr Trp 
        275                 280                 285             


Asn Ser Gly Glu Pro Asn Asn Ser Gly Asn Glu Asp Cys Ala Glu Phe 
    290                 295                 300                 


Ser Gly Ser Gly Trp Asn Asp Asn Arg Cys Asp Val Asp Asn Tyr Trp 
305                 310                 315                 320 


Ile Cys Lys Lys Pro Ala Ala Cys Phe Arg Asp Glu 
                325                 330         


<210> 6327
<211> 332
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<400> 6327
Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Xaa Xaa Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Xaa Val Pro Phe Leu Leu 
        35                  40                  45              


Gly Pro Val Ser Lys Val Pro Ser Ser Leu Ser Gln Glu Gln Ser Glu 
    50                  55                  60                  


Gln Asp Ala Ile Tyr Gln Asn Leu Xaa Gln Leu Lys Ala Ala Val Gly 
65                  70                  75                  80  


Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa 
                85                  90                  95      


Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
            100                 105                 110         


Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu 
        115                 120                 125             


Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu 
    130                 135                 140                 


Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile 
145                 150                 155                 160 


Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
                165                 170                 175     


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Glu Leu Lys Ala 
            180                 185                 190         


Ala Val Glu Arg Leu Cys Arg His Cys Pro Lys Asp Trp Xaa Phe Phe 
        195                 200                 205             


Gln Gly Asn Cys Tyr Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp 
    210                 215                 220                 


Ser Val Xaa Ala Cys Gln Glu Val Arg Ala Gln Leu Val Val Ile Lys 
225                 230                 235                 240 


Xaa Ala Glu Glu Gln Asn Phe Leu Gln Leu Gln Xaa Ser Arg Ser Asn 
                245                 250                 255     


Arg Phe Ser Trp Met Gly Leu Ser Asp Leu Asn Gln Glu Gly Xaa Trp 
            260                 265                 270         


Gln Trp Val Asp Gly Ser Pro Leu Ser Pro Ser Phe Gln Arg Tyr Trp 
        275                 280                 285             


Asn Ser Gly Glu Pro Asn Asn Ser Gly Asn Glu Asp Cys Ala Glu Phe 
    290                 295                 300                 


Ser Gly Ser Gly Trp Asn Asp Asn Arg Cys Asp Val Asp Asn Tyr Trp 
305                 310                 315                 320 


Ile Cys Lys Lys Pro Ala Ala Cys Phe Arg Asp Glu 
                325                 330         


<210> 6328
<211> 282
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<400> 6328
Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Xaa Xaa Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Xaa Val Ser Lys Val Pro 
        35                  40                  45              


Ser Ser Leu Ser Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn 
    50                  55                  60                  


Leu Xaa Gln Leu Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys 
65                  70                  75                  80  


Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Gln Leu Lys Ala Ala Val Gly 
                85                  90                  95      


Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa 
            100                 105                 110         


Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
        115                 120                 125             


Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu 
    130                 135                 140                 


Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu 
145                 150                 155                 160 


Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile 
                165                 170                 175     


Tyr Gln Glu Leu Xaa Glu Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
            180                 185                 190         


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Gln Leu Lys Ala 
        195                 200                 205             


Ala Val Gly Glu Leu Pro Asp Gln Ser Lys Gln Gln Gln Ile Tyr Gln 
    210                 215                 220                 


Glu Leu Xaa Asp Leu Lys Xaa Ala Phe Glu Arg Leu Cys Arg His Cys 
225                 230                 235                 240 


Pro Lys Asp Trp Xaa Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn 
                245                 250                 255     


Ser Gln Arg Asn Trp His Asp Ser Val Xaa Ala Cys Gln Glu Val Arg 
            260                 265                 270         


Ala Gln Leu Val Val Ile Lys Xaa Ala Glu 
        275                 280         


<210> 6329
<211> 348
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<400> 6329
Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Gly 
1               5                   10                  15      


Cys Leu Gly His Gly Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu 
            20                  25                  30          


Leu Ala Gly Val Leu Val Ala Ile Leu Val Gln Val Ser Lys Val Pro 
        35                  40                  45              


Ser Ser Leu Ser Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn 
    50                  55                  60                  


Leu Xaa Gln Leu Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys 
65                  70                  75                  80  


Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Gln Leu Lys Ala Ala Val Gly 
                85                  90                  95      


Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa 
            100                 105                 110         


Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
        115                 120                 125             


Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu 
    130                 135                 140                 


Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Glu Leu 
145                 150                 155                 160 


Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile 
                165                 170                 175     


Tyr Gln Glu Leu Xaa Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Asp 
            180                 185                 190         


Gln Ser Lys Gln Gln Gln Ile Tyr Gln Glu Leu Xaa Asp Leu Lys Xaa 
        195                 200                 205             


Ala Phe Glu Arg Leu Cys Arg His Cys Pro Lys Asp Trp Xaa Phe Phe 
    210                 215                 220                 


Gln Gly Asn Cys Tyr Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp 
225                 230                 235                 240 


Ser Val Xaa Ala Cys Gln Glu Val Arg Ala Gln Leu Val Val Ile Lys 
                245                 250                 255     


Xaa Ala Glu Glu Gln Asn Phe Leu Gln Leu Gln Xaa Ser Arg Ser Asn 
            260                 265                 270         


Arg Phe Ser Trp Met Gly Leu Ser Asp Leu Asn Gln Glu Gly Xaa Trp 
        275                 280                 285             


Gln Trp Val Asp Gly Ser Pro Leu Ser Pro Ser Phe Gln Arg Tyr Trp 
    290                 295                 300                 


Asn Ser Gly Glu Pro Asn Asn Ser Gly Asn Glu Asp Cys Ala Glu Phe 
305                 310                 315                 320 


Ser Gly Ser Gly Trp Asn Asp Asn Arg Cys Asp Val Asp Asn Tyr Trp 
                325                 330                 335     


Ile Cys Lys Lys Pro Ala Ala Cys Phe Arg Asp Glu 
            340                 345             


<210> 6330
<211> 296
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<400> 6330
Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Gly 
1               5                   10                  15      


Cys Leu Gly His Gly Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu 
            20                  25                  30          


Leu Ala Gly Val Leu Val Ala Ile Leu Val Gln Val Ser Lys Val Pro 
        35                  40                  45              


Ser Ser Leu Ser Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn 
    50                  55                  60                  


Leu Xaa Gln Leu Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys 
65                  70                  75                  80  


Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Gln Leu Lys Ala Ala Val Gly 
                85                  90                  95      


Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa 
            100                 105                 110         


Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
        115                 120                 125             


Glu Ile Tyr Gln Glu Leu Xaa Arg Leu Lys Ala Ala Val Gly Glu Leu 
    130                 135                 140                 


Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Arg Leu 
145                 150                 155                 160 


Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile 
                165                 170                 175     


Tyr Gln Glu Leu Xaa Glu Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
            180                 185                 190         


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Xaa Gln Leu Lys Ala 
        195                 200                 205             


Ala Val Gly Glu Leu Pro Asp Gln Ser Lys Gln Gln Gln Ile Tyr Gln 
    210                 215                 220                 


Glu Leu Xaa Asp Leu Lys Xaa Ala Phe Glu Arg Leu Cys Arg His Cys 
225                 230                 235                 240 


Pro Lys Asp Trp Xaa Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn 
                245                 250                 255     


Ser Gln Arg Asn Trp His Asp Ser Val Xaa Ala Cys Gln Glu Val Arg 
            260                 265                 270         


Ala Gln Leu Val Val Ile Lys Xaa Ala Glu Glu Gln Leu Pro Ala Val 
        275                 280                 285             


Leu Glu Gln Trp Arg Xaa Gln Gln 
    290                 295     


<210> 6331
<211> 53
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<400> 6331
Met Asn Trp His Met Ile Ile Ser Gly Leu Ile Val Val Val Leu Lys 
1               5                   10                  15      


Val Val Gly Met Xaa Leu Phe Leu Leu Tyr Phe Pro Gln Ile Phe Asn 
            20                  25                  30          


Lys Ser Asn Asp Gly Phe Xaa Xaa Xaa Arg Ser Tyr Gly Xaa Glu Val 
        35                  40                  45              


Ser Ser Gly His Asn 
    50              


<210> 6332
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<400> 6332
Met Asn Trp His Met Ile Ile Ser Gly Leu Ile Val Val Val Leu Lys 
1               5                   10                  15      


Val Val Gly Met Xaa Leu Phe Leu Leu Tyr Phe Pro Gln Ile Phe Asn 
            20                  25                  30          


Lys Ser Asn Asp Gly Phe Xaa Xaa Xaa Arg Ser Tyr Gly Xaa Val Cys 
        35                  40                  45              


Pro Lys Asp Trp Glu Phe Tyr Gln Ala Arg Cys Phe Phe Leu Ser Xaa 
    50                  55                  60                  


Ser Glu Ser Ser Trp Asn Glu Ser Arg Asp Phe Cys Lys Gly Lys Gly 
65                  70                  75                  80  


Ser Xaa Leu Ala Ile Val Asn Xaa Pro Glu Lys Leu Lys Phe Leu Gln 
                85                  90                  95      


Asp Ile Xaa Asp Ala Glu Lys Tyr Phe Ile Gly Leu Ile Tyr His Arg 
            100                 105                 110         


Glu Glu Lys Arg Trp Arg Trp Ile Asn Asn Ser Val Phe Asn Gly Lys 
        115                 120                 125             


Tyr Val Asn Met Pro Gln Phe Pro Gly Asp Leu Gly Leu Leu Gln Lys 
    130                 135                 140                 


Xaa Lys Pro Glu Ile Ala Gly Phe Xaa Leu Glu 
145                 150                 155 


<210> 6333
<211> 165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<400> 6333
Met Asn Trp His Met Ile Ile Ser Gly Leu Ile Val Val Val Leu Lys 
1               5                   10                  15      


Val Val Gly Met Xaa Leu Phe Leu Leu Tyr Phe Pro Gln Ile Phe Asn 
            20                  25                  30          


Lys Ser Asn Asp Gly Phe Xaa Xaa Xaa Arg Ser Tyr Gly Xaa Val Cys 
        35                  40                  45              


Pro Lys Asp Trp Glu Phe Tyr Gln Ala Arg Cys Phe Phe Leu Ser Xaa 
    50                  55                  60                  


Ser Glu Ser Ser Trp Asn Glu Ser Arg Asp Phe Cys Lys Gly Lys Gly 
65                  70                  75                  80  


Ser Xaa Leu Ala Ile Val Asn Xaa Pro Glu Lys Leu Lys Phe Leu Gln 
                85                  90                  95      


Asp Ile Xaa Asp Ala Glu Lys Tyr Phe Ile Gly Leu Ile Tyr His Arg 
            100                 105                 110         


Glu Glu Lys Arg Trp Arg Trp Ile Asn Asn Ser Val Phe Asn Gly Asn 
        115                 120                 125             


Val Xaa Asn Gln Asn Gln Asn Phe Asn Cys Ala Xaa Ile Gly Leu Xaa 
    130                 135                 140                 


Lys Xaa Phe Asp Ala Ala Ser Cys Asp Ile Ser Tyr Arg Arg Ile Cys 
145                 150                 155                 160 


Glu Lys Asn Ala Lys 
                165 


<210> 6334
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 6334
Met Asn Trp His Met Ile Ile Ser Gly Leu Ile Val Val Val Leu Lys 
1               5                   10                  15      


Val Val Gly Met Xaa Leu Phe Leu Leu Tyr Phe Pro Gln Ile Phe Asn 
            20                  25                  30          


Lys Ser Asn Asp Gly Phe Xaa Xaa Xaa Arg Ser Tyr Gly Xaa Val Ser 
        35                  40                  45              


Gln Ile Phe Gly Ser Ser Ser Pro Ser Pro Asn Gly Phe Ile Xaa Xaa 
    50                  55                  60                  


Arg Ser Tyr Gly Xaa Val Cys Pro Lys Asp Trp Glu Phe Tyr Gln Ala 
65                  70                  75                  80  


Arg Cys Phe Phe Leu Ser Xaa Ser Glu Ser Ser Trp Asn Glu Ser Arg 
                85                  90                  95      


Asp Phe Cys Lys Gly Lys Gly Ser Xaa Leu Ala Ile Val Asn Xaa Pro 
            100                 105                 110         


Glu Lys Leu Lys Phe Leu Gln Asp Ile Xaa Asp Ala Glu Lys Tyr Phe 
        115                 120                 125             


Ile Gly Leu Ile Tyr His Arg Glu Glu Lys Arg Trp Arg Trp Ile Asn 
    130                 135                 140                 


Asn Ser Val Phe Asn Gly Asn Val Xaa Asn Gln Asn Gln Asn Phe Asn 
145                 150                 155                 160 


Cys Ala Xaa Ile Gly Leu Xaa Lys Xaa Phe Asp Ala Ala Ser Cys Asp 
                165                 170                 175     


Ile Ser Tyr Arg Arg Ile Cys Glu Lys Asn Ala Lys 
            180                 185             


<210> 6335
<211> 84
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<400> 6335
Met Val Ser Pro Pro Pro Gly Ala Met Glu Gln Lys Phe Leu Gln Asp 
1               5                   10                  15      


Ile Xaa Asp Ala Glu Lys Tyr Phe Ile Gly Leu Ile Tyr His Arg Glu 
            20                  25                  30          


Glu Lys Arg Trp Arg Trp Ile Asn Asn Ser Val Phe Asn Gly Asn Val 
        35                  40                  45              


Xaa Asn Gln Asn Gln Asn Phe Asn Cys Ala Xaa Ile Gly Leu Xaa Lys 
    50                  55                  60                  


Xaa Phe Asp Ala Ala Ser Cys Asp Ile Ser Tyr Arg Arg Ile Cys Glu 
65                  70                  75                  80  


Lys Asn Ala Lys 
                


<210> 6336
<211> 209
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<400> 6336
Met Met Gln Glu Gln Gln Pro Gln Ser Xaa Glu Lys Arg Gly Trp Leu 
1               5                   10                  15      


Ser Leu Arg Leu Trp Ser Val Ala Gly Ile Ser Ile Ala Leu Leu Ser 
            20                  25                  30          


Ala Cys Phe Ile Val Ser Cys Val Val Xaa Tyr His Phe Xaa Tyr Gly 
        35                  40                  45              


Glu Xaa Gly Lys Arg Leu Ser Glu Leu His Ser Tyr His Ser Ser Leu 
    50                  55                  60                  


Xaa Cys Phe Ser Glu Gly Xaa Lys Val Pro Ala Trp Gly Cys Cys Pro 
65                  70                  75                  80  


Ala Ser Trp Lys Ser Phe Gly Ser Ser Cys Tyr Phe Ile Ser Ser Glu 
                85                  90                  95      


Glu Lys Val Trp Ser Lys Ser Glu Gln Asn Cys Val Glu Met Gly Ala 
            100                 105                 110         


His Leu Val Val Phe Asn Xaa Glu Ala Glu Gln Asn Phe Ile Val Gln 
        115                 120                 125             


Gln Leu Asn Glu Ser Phe Ser Tyr Phe Leu Gly Leu Ser Asp Pro Gln 
    130                 135                 140                 


Gly Asn Asn Asn Trp Gln Trp Ile Asp Lys Xaa Pro Tyr Glu Lys Asn 
145                 150                 155                 160 


Val Arg Phe Trp His Leu Gly Glu Pro Asn His Ser Ala Glu Gln Cys 
                165                 170                 175     


Ala Ser Ile Val Phe Trp Lys Pro Xaa Gly Trp Gly Trp Asn Asp Val 
            180                 185                 190         


Ile Cys Glu Xaa Arg Arg Asn Ser Ile Cys Glu Met Asn Lys Ile Tyr 
        195                 200                 205             


Leu 
    


<210> 6337
<211> 45
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<400> 6337
Met Glu Tyr His Pro Asp Leu Glu Asn Leu Asp Glu Asp Gly Tyr Xaa 
1               5                   10                  15      


Gln Leu His Phe Asp Ser Gln Ser Asn Xaa Arg Ile Ala Val Val Ser 
            20                  25                  30          


Glu Lys Gly Ile Tyr Ser Lys Xaa Ser Val Phe Pro Xaa 
        35                  40                  45  


<210> 6338
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 6338
Met Glu Tyr His Pro Asp Leu Glu Asn Leu Asp Glu Asp Gly Tyr Xaa 
1               5                   10                  15      


Gln Leu His Phe Asp Ser Gln Ser Asn Xaa Arg Ile Ala Val Val Ser 
            20                  25                  30          


Glu Lys Gly Ser Cys Ala Ala Ser Pro Pro Trp Arg Leu Ile Ala Val 
        35                  40                  45              


Ile Leu Gly Ile Leu Cys Leu Val Ile Leu Val Ile Ala Val Val Leu 
    50                  55                  60                  


Gly Xaa Met Ala Gly Phe Lys Ala Val Glu Phe Lys Gly 
65                  70                  75          


<210> 6339
<211> 247
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<400> 6339
Met Glu Tyr His Pro Asp Leu Glu Asn Leu Asp Glu Asp Gly Tyr Xaa 
1               5                   10                  15      


Gln Leu His Phe Asp Ser Gln Ser Asn Xaa Arg Ile Ala Val Val Ser 
            20                  25                  30          


Glu Lys Gly Ser Cys Ala Ala Ser Pro Pro Trp Arg Leu Ile Ala Val 
        35                  40                  45              


Ile Leu Gly Ile Leu Cys Leu Val Ile Leu Val Ile Ala Val Val Leu 
    50                  55                  60                  


Gly Xaa Met Ala Ile Trp Arg Ser Asn Ser Gly Ser Asn Xaa Leu Glu 
65                  70                  75                  80  


Asn Gly Tyr Phe Leu Ser Arg Asn Lys Glu Asn His Ser Gln Pro Xaa 
                85                  90                  95      


Gln Ser Ser Leu Glu Asp Ser Val Xaa Pro Xaa Lys Ala Val Lys Xaa 
            100                 105                 110         


Xaa Gly Val Leu Ser Ser Pro Cys Pro Pro Asn Trp Ile Ile Tyr Glu 
        115                 120                 125             


Lys Ser Cys Tyr Leu Phe Ser Met Ser Leu Asn Ser Trp Asp Gly Ser 
    130                 135                 140                 


Lys Arg Gln Cys Trp Gln Leu Gly Ser Asn Leu Leu Lys Ile Asp Ser 
145                 150                 155                 160 


Ser Asn Glu Leu Gly Phe Ile Val Lys Gln Val Ser Ser Gln Pro Asp 
                165                 170                 175     


Asn Ser Phe Trp Ile Gly Leu Ser Arg Pro Gln Xaa Glu Val Pro Trp 
            180                 185                 190         


Leu Trp Glu Asp Gly Ser Xaa Phe Ser Ser Asn Leu Phe Gln Ile Arg 
        195                 200                 205             


Xaa Xaa Ala Xaa Gln Glu Asn Pro Ser Pro Asn Cys Val Trp Ile His 
    210                 215                 220                 


Val Ser Val Ile Tyr Asp Gln Leu Cys Ser Val Pro Ser Tyr Ser Ile 
225                 230                 235                 240 


Cys Glu Lys Lys Phe Ser Met 
                245         


<210> 6340
<211> 189
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(113)
<223> Selenocysteine

<400> 6340
Met Glu Tyr His Pro Asp Leu Glu Asn Leu Asp Glu Asp Gly Tyr Xaa 
1               5                   10                  15      


Gln Leu His Phe Asp Ser Gln Ser Asn Xaa Arg Ile Ala Val Val Ser 
            20                  25                  30          


Glu Lys Gly Ser Cys Ala Ala Ser Pro Pro Trp Arg Leu Ile Ala Val 
        35                  40                  45              


Ile Leu Gly Ile Leu Cys Leu Val Ile Leu Val Ile Ala Val Val Leu 
    50                  55                  60                  


Gly Xaa Met Ala Ile Trp Arg Ser Asn Ser Gly Ser Asn Xaa Leu Glu 
65                  70                  75                  80  


Asn Gly Tyr Phe Leu Ser Arg Asn Lys Glu Asn His Ser Gln Pro Xaa 
                85                  90                  95      


Gln Ser Ser Leu Glu Asp Ser Val Xaa Pro Xaa Lys Ala Val Lys Xaa 
            100                 105                 110         


Xaa Gly Val Leu Ser Ser Pro Cys Pro Pro Asn Trp Ile Ile Tyr Glu 
        115                 120                 125             


Lys Ser Cys Tyr Leu Phe Ser Met Ser Leu Asn Ser Trp Asp Gly Ser 
    130                 135                 140                 


Lys Arg Gln Cys Trp Gln Leu Gly Ser Asn Leu Leu Lys Ile Asp Ser 
145                 150                 155                 160 


Ser Asn Glu Leu Ile Ser Asp Gln Asn His Ser Tyr Pro Arg Lys Pro 
                165                 170                 175     


Ile Ser Lys Leu Cys Met Asp Ser Arg Val Ser His Leu 
            180                 185                 


<210> 6341
<211> 192
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<400> 6341
Met Glu Tyr His Pro Asp Leu Glu Asn Leu Asp Glu Asp Gly Tyr Xaa 
1               5                   10                  15      


Gln Leu His Phe Asp Ser Gln Ser Asn Xaa Arg Ile Ala Val Val Ser 
            20                  25                  30          


Glu Lys Gly Ser Cys Ala Ala Ser Pro Pro Trp Arg Leu Ile Ala Val 
        35                  40                  45              


Ile Leu Gly Ile Leu Cys Leu Val Ile Leu Val Ile Ala Val Val Leu 
    50                  55                  60                  


Gly Xaa Met Ala Ile Trp Arg Ser Asn Ser Gly Ser Asn Xaa Leu Glu 
65                  70                  75                  80  


Asn Gly Tyr Phe Leu Ser Arg Asn Lys Glu Asn His Ser Gln Pro Xaa 
                85                  90                  95      


Gln Ser Ser Leu Glu Asp Ser Val Xaa Pro Xaa Lys Ala Val Lys Xaa 
            100                 105                 110         


Xaa Gly Val Leu Ser Ser Pro Cys Pro Pro Asn Trp Ile Ile Tyr Glu 
        115                 120                 125             


Lys Ser Cys Tyr Leu Phe Ser Met Ser Leu Asn Ser Trp Asp Gly Ser 
    130                 135                 140                 


Lys Arg Gln Cys Trp Gln Leu Gly Ser Asn Leu Leu Lys Ile Asp Ser 
145                 150                 155                 160 


Ser Asn Glu Leu Ser Leu Xaa Leu Leu Pro Lys Leu Glu Cys Ser Glu 
                165                 170                 175     


Ala Ala Xaa Ser Gln Ala Gln Val Ile Leu Pro Pro Gln Leu Pro Glu 
            180                 185                 190         


<210> 6342
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<400> 6342
Met Glu Tyr His Pro Asp Leu Glu Asn Leu Asp Glu Asp Gly Tyr Xaa 
1               5                   10                  15      


Gln Leu His Phe Asp Ser Gln Ser Asn Xaa Arg Ile Ala Val Val Ser 
            20                  25                  30          


Glu Lys Gly Ser Cys Ala Ala Ser Pro Pro Trp Arg Leu Ile Ala Val 
        35                  40                  45              


Ile Leu Gly Ile Leu Cys Leu Val Ile Leu Val Ile Ala Val Val Leu 
    50                  55                  60                  


Gly Xaa Met Gly Glu Tyr Leu Val Glu Glu Ile Asn Asn Arg Gln Phe 
65                  70                  75                  80  


Ser Lys Gln Leu Leu Cys Ala Arg His Ser Phe Lys Gly Leu Xaa Cys 
                85                  90                  95      


Ile Ile Tyr Phe Asn Leu Tyr Ile Ile Trp Phe Tyr Leu Tyr Trp Val 
            100                 105                 110         


Gly Ala Val Asn Ala His Phe Xaa Tyr Lys Gly Cys Glu Arg Leu Arg 
        115                 120                 125             


Gly Tyr Phe Xaa Phe Pro Gly Leu 
    130                 135     


<210> 6343
<211> 116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(109)
<223> Selenocysteine

<400> 6343
Met Glu Tyr His Pro Asp Leu Glu Asn Leu Asp Glu Asp Gly Tyr Xaa 
1               5                   10                  15      


Gln Leu His Phe Asp Ser Gln Ser Asn Xaa Arg Ile Ala Val Val Ser 
            20                  25                  30          


Glu Lys Gly Ser Cys Ala Ala Ser Pro Pro Trp Arg Leu Ile Ala Val 
        35                  40                  45              


Ile Leu Gly Ile Leu Cys Leu Val Ile Leu Val Ile Ala Val Val Leu 
    50                  55                  60                  


Gly Xaa Met Gly Xaa Gly Gln Phe Leu Lys Asp Leu Ser Phe Leu Asn 
65                  70                  75                  80  


Asn Arg Arg Lys Leu Phe Gly Asp Pro Ile Gln Glu Ala Xaa His Trp 
                85                  90                  95      


Arg Met Ala Xaa Phe Tyr Gln Glu Ile Lys Arg Xaa Xaa Val Asn Pro 
            100                 105                 110         


His Asn His Leu 
        115     


<210> 6344
<211> 201
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 6344
Met Glu Tyr His Pro Asp Leu Glu Asn Leu Asp Glu Asp Gly Tyr Xaa 
1               5                   10                  15      


Gln Leu His Phe Asp Ser Gln Ser Asn Xaa Arg Ile Ala Val Val Ser 
            20                  25                  30          


Glu Lys Gly Ser Cys Ala Ala Ser Pro Pro Trp Arg Leu Ile Ala Val 
        35                  40                  45              


Ile Leu Gly Ile Leu Cys Leu Val Ile Leu Val Ile Ala Val Val Leu 
    50                  55                  60                  


Gly Xaa Met Gly Val Leu Ser Ser Pro Cys Pro Pro Asn Trp Ile Ile 
65                  70                  75                  80  


Tyr Glu Lys Ser Cys Tyr Leu Phe Ser Met Ser Leu Asn Ser Trp Asp 
                85                  90                  95      


Gly Ser Lys Arg Gln Cys Trp Gln Leu Gly Ser Asn Leu Leu Lys Ile 
            100                 105                 110         


Asp Ser Ser Asn Glu Leu Gly Phe Ile Val Lys Gln Val Ser Ser Gln 
        115                 120                 125             


Pro Asp Asn Ser Phe Trp Ile Gly Leu Ser Arg Pro Gln Xaa Glu Val 
    130                 135                 140                 


Pro Trp Leu Trp Glu Asp Gly Ser Xaa Phe Ser Ser Asn Leu Phe Gln 
145                 150                 155                 160 


Ile Arg Xaa Xaa Ala Xaa Gln Glu Asn Pro Ser Pro Asn Cys Val Trp 
                165                 170                 175     


Ile His Val Ser Val Ile Tyr Asp Gln Leu Cys Ser Val Pro Ser Tyr 
            180                 185                 190         


Ser Ile Cys Glu Lys Lys Phe Ser Met 
        195                 200     


<210> 6345
<211> 143
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 6345
Met Glu Tyr His Pro Asp Leu Glu Asn Leu Asp Glu Asp Gly Tyr Xaa 
1               5                   10                  15      


Gln Leu His Phe Asp Ser Gln Ser Asn Xaa Arg Ile Ala Val Val Ser 
            20                  25                  30          


Glu Lys Gly Ser Cys Ala Ala Ser Pro Pro Trp Arg Leu Ile Ala Val 
        35                  40                  45              


Ile Leu Gly Ile Leu Cys Leu Val Ile Leu Val Ile Ala Val Val Leu 
    50                  55                  60                  


Gly Xaa Met Gly Val Leu Ser Ser Pro Cys Pro Pro Asn Trp Ile Ile 
65                  70                  75                  80  


Tyr Glu Lys Ser Cys Tyr Leu Phe Ser Met Ser Leu Asn Ser Trp Asp 
                85                  90                  95      


Gly Ser Lys Arg Gln Cys Trp Gln Leu Gly Ser Asn Leu Leu Lys Ile 
            100                 105                 110         


Asp Ser Ser Asn Glu Leu Ile Ser Asp Gln Asn His Ser Tyr Pro Arg 
        115                 120                 125             


Lys Pro Ile Ser Lys Leu Cys Met Asp Ser Arg Val Ser His Leu 
    130                 135                 140             


<210> 6346
<211> 168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<400> 6346
Met Glu Tyr His Pro Asp Leu Glu Asn Leu Asp Glu Asp Gly Tyr Xaa 
1               5                   10                  15      


Gln Leu His Phe Asp Ser Gln Ser Asn Xaa Arg Ile Ala Val Val Ser 
            20                  25                  30          


Glu Lys Gly Val Leu Ser Ser Pro Cys Pro Pro Asn Trp Ile Ile Tyr 
        35                  40                  45              


Glu Lys Ser Cys Tyr Leu Phe Ser Met Ser Leu Asn Ser Trp Asp Gly 
    50                  55                  60                  


Ser Lys Arg Gln Cys Trp Gln Leu Gly Ser Asn Leu Leu Lys Ile Asp 
65                  70                  75                  80  


Ser Ser Asn Glu Leu Gly Phe Ile Val Lys Gln Val Ser Ser Gln Pro 
                85                  90                  95      


Asp Asn Ser Phe Trp Ile Gly Leu Ser Arg Pro Gln Xaa Glu Val Pro 
            100                 105                 110         


Trp Leu Trp Glu Asp Gly Ser Xaa Phe Ser Ser Asn Leu Phe Gln Ile 
        115                 120                 125             


Arg Xaa Xaa Ala Xaa Gln Glu Asn Pro Ser Pro Asn Cys Val Trp Ile 
    130                 135                 140                 


His Val Ser Val Ile Tyr Asp Gln Leu Cys Ser Val Pro Ser Tyr Ser 
145                 150                 155                 160 


Ile Cys Glu Lys Lys Phe Ser Met 
                165             


<210> 6347
<211> 241
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<400> 6347
Met Ala Glu Glu Gln Pro Gln Val Glu Leu Phe Val Lys Ala Gly Ser 
1               5                   10                  15      


Asp Gly Ala Lys Ile Gly Asn Cys Pro Phe Ser Gln Arg Leu Phe Met 
            20                  25                  30          


Val Leu Trp Leu Lys Gly Val Xaa Phe Asn Val Xaa Xaa Val Asp Xaa 
        35                  40                  45              


Lys Arg Arg Xaa Glu Xaa Val Gln Lys Leu Cys Pro Gly Gly Gln Leu 
    50                  55                  60                  


Pro Phe Leu Leu Tyr Gly Xaa Glu Val His Xaa Asp Xaa Asn Lys Ile 
65                  70                  75                  80  


Glu Glu Phe Leu Glu Ala Val Leu Cys Pro Pro Arg Tyr Pro Lys Leu 
                85                  90                  95      


Ala Ala Leu Asn Pro Glu Ser Asn Xaa Ala Gly Leu Asp Ile Phe Ala 
            100                 105                 110         


Lys Phe Ser Ala Tyr Ile Lys Asn Ser Asn Pro Ala Leu Asn Asp Asn 
        115                 120                 125             


Leu Glu Lys Gly Leu Leu Lys Ala Leu Lys Val Leu Asp Asn Tyr Leu 
    130                 135                 140                 


Xaa Ser Pro Leu Pro Glu Glu Val Asp Glu Xaa Ser Ala Glu Asp Glu 
145                 150                 155                 160 


Gly Val Ser Gln Arg Lys Phe Leu Asp Gly Asn Glu Leu Xaa Leu Ala 
                165                 170                 175     


Asp Cys Asn Leu Leu Pro Lys Leu His Ile Val Gln Val Val Cys Lys 
            180                 185                 190         


Lys Tyr Arg Gly Phe Xaa Ile Pro Glu Ala Phe Arg Gly Val His Arg 
        195                 200                 205             


Tyr Leu Ser Asn Ala Tyr Ala Arg Glu Glu Phe Ala Ser Xaa Cys Pro 
    210                 215                 220                 


Asp Asp Glu Glu Ile Glu Leu Ala Tyr Glu Gln Val Ala Lys Ala Leu 
225                 230                 235                 240 


Lys 
    


<210> 6348
<211> 247
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<400> 6348
Met Ser Gly Leu Arg Pro Gly Xaa Gln Val Asp Pro Glu Ile Glu Leu 
1               5                   10                  15      


Phe Val Lys Ala Gly Ser Asp Gly Glu Ser Ile Gly Asn Cys Pro Phe 
            20                  25                  30          


Cys Gln Arg Leu Phe Met Ile Leu Trp Leu Lys Gly Val Lys Phe Asn 
        35                  40                  45              


Val Xaa Xaa Val Asp Met Xaa Arg Lys Pro Glu Glu Leu Lys Asp Leu 
    50                  55                  60                  


Ala Pro Gly Xaa Asn Pro Pro Phe Leu Val Tyr Asn Lys Glu Leu Lys 
65                  70                  75                  80  


Xaa Asp Phe Ile Lys Ile Glu Glu Phe Leu Glu Gln Xaa Leu Ala Pro 
                85                  90                  95      


Pro Arg Tyr Pro His Leu Ser Pro Lys Tyr Lys Glu Ser Phe Asp Val 
            100                 105                 110         


Gly Cys Asn Leu Phe Ala Lys Phe Ser Ala Tyr Ile Lys Asn Xaa Gln 
        115                 120                 125             


Lys Glu Ala Asn Lys Asn Phe Glu Lys Ser Leu Leu Lys Glu Phe Lys 
    130                 135                 140                 


Arg Leu Asp Asp Tyr Leu Asn Xaa Pro Leu Leu Asp Glu Ile Asp Pro 
145                 150                 155                 160 


Asp Ser Ala Glu Glu Pro Pro Val Ser Arg Arg Leu Phe Leu Asp Gly 
                165                 170                 175     


Asp Gln Leu Xaa Leu Ala Asp Cys Ser Leu Leu Pro Lys Leu Asn Ile 
            180                 185                 190         


Ile Lys Val Ala Ala Lys Lys Tyr Arg Asp Phe Asp Ile Pro Ala Glu 
        195                 200                 205             


Phe Ser Gly Val Trp Arg Tyr Leu His Asn Ala Tyr Ala Arg Glu Glu 
    210                 215                 220                 


Phe Xaa His Xaa Cys Pro Glu Asp Lys Glu Ile Glu Asn Xaa Tyr Ala 
225                 230                 235                 240 


Asn Val Ala Lys Gln Lys Ser 
                245         


<210> 6349
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 6349
Met Ser Gly Leu Arg Pro Gly Xaa Gln Val Asp Pro Glu Ile Glu Leu 
1               5                   10                  15      


Phe Val Lys Ala Gly Ser Asp Gly Glu Ser Ile Gly Asn Cys Pro Phe 
            20                  25                  30          


Cys Gln Arg Leu Phe Met Ile Leu Trp Leu Lys Gly Val Lys Phe Asn 
        35                  40                  45              


Val Xaa Xaa Val Asp Met Xaa Arg Tyr Pro His Leu Ser Pro Lys Tyr 
    50                  55                  60                  


Lys Glu Ser Phe Asp Val Gly Cys Asn Leu Phe Ala Lys Phe Ser Ala 
65                  70                  75                  80  


Tyr Ile Lys Asn Xaa Gln Lys Glu Ala Asn Lys Asn Phe Glu Lys Ser 
                85                  90                  95      


Leu Leu Lys Glu Phe Lys Arg Leu Asp Asp Tyr Leu Asn Xaa Pro Leu 
            100                 105                 110         


Leu Asp Glu Ile Asp Pro Asp Ser Ala Glu Glu Pro Pro Val Ser Arg 
        115                 120                 125             


Arg Leu Phe Leu Asp 
    130             


<210> 6350
<211> 236
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<400> 6350
Met Ala Glu Xaa Lys Leu Gln Leu Phe Val Lys Ala Ser Glu Asp Gly 
1               5                   10                  15      


Glu Ser Val Gly His Cys Pro Ser Cys Gln Arg Leu Phe Met Val Leu 
            20                  25                  30          


Leu Leu Lys Gly Val Pro Phe Xaa Leu Xaa Xaa Val Asp Xaa Arg Arg 
        35                  40                  45              


Ser Pro Asp Val Leu Lys Asp Phe Ala Pro Gly Ser Gln Leu Pro Ile 
    50                  55                  60                  


Leu Leu Tyr Asp Ser Asp Ala Lys Xaa Asp Xaa Leu Gln Ile Glu Asp 
65                  70                  75                  80  


Phe Leu Glu Glu Xaa Leu Gly Pro Pro Asp Phe Pro Ser Leu Ala Pro 
                85                  90                  95      


Arg Tyr Arg Glu Ser Asn Xaa Ala Gly Asn Asp Val Phe His Lys Phe 
            100                 105                 110         


Ser Ala Phe Ile Lys Asn Pro Val Pro Ala Gln Asp Glu Ala Leu Tyr 
        115                 120                 125             


Gln Gln Leu Leu Arg Ala Leu Ala Arg Leu Asp Ser Tyr Leu Arg Ala 
    130                 135                 140                 


Pro Leu Glu His Glu Leu Ala Gly Glu Pro Gln Leu Arg Glu Ser Arg 
145                 150                 155                 160 


Arg Arg Phe Leu Asp Gly Asp Arg Leu Xaa Leu Ala Asp Cys Ser Leu 
                165                 170                 175     


Leu Pro Lys Leu His Ile Val Asp Xaa Val Cys Ala His Phe Arg Gln 
            180                 185                 190         


Ala Pro Ile Pro Ala Glu Leu Arg Gly Val Arg Arg Tyr Leu Asp Ser 
        195                 200                 205             


Ala Met Gln Glu Lys Glu Phe Lys Tyr Xaa Cys Pro His Ser Ala Glu 
    210                 215                 220                 


Ile Leu Ala Ala Tyr Arg Pro Ala Val His Pro Arg 
225                 230                 235     


<210> 6351
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<400> 6351
Met Xaa Lys Xaa Asp Pro Ala Pro Met Ala Pro Pro Pro Arg Gly Glu 
1               5                   10                  15      


Glu Glu Glu Glu Glu Glu Glu Asp Glu Pro Val Pro Glu Ala Pro Ser 
            20                  25                  30          


Pro Xaa Gln Glu Arg Arg Gln Lys Pro Val Val His Pro Ser Ala Pro 
        35                  40                  45              


Ala Pro Leu Pro Lys Asp Tyr Ala Phe Xaa Phe Phe Asp Pro Asn Asp 
    50                  55                  60                  


Pro Ala Cys Gln Glu Ile Leu Phe Asp Pro Gln Xaa Xaa Ile Pro Glu 
65                  70                  75                  80  


Leu Phe Ala Ile Val Arg Gln Trp Val Pro Gln Val Gln His Lys Ile 
                85                  90                  95      


Asp Val Ile Gly Asn Glu Ile Leu Arg Arg Gly Cys His Val Asn Asp 
            100                 105                 110         


Arg Asp Gly Leu Xaa Asp Met Xaa Leu Leu His Tyr Ala Cys Lys Ala 
        115                 120                 125             


Gly Ala His Gly Val 
    130             


<210> 6352
<211> 547
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<400> 6352
Met Xaa Lys Xaa Asp Pro Ala Pro Met Ala Pro Pro Pro Arg Gly Glu 
1               5                   10                  15      


Glu Glu Glu Glu Glu Glu Glu Asp Glu Pro Val Pro Glu Ala Pro Ser 
            20                  25                  30          


Pro Xaa Gln Glu Arg Arg Gln Lys Pro Val Val His Pro Ser Ala Pro 
        35                  40                  45              


Ala Pro Leu Pro Lys Asp Tyr Ala Phe Xaa Phe Phe Asp Pro Asn Asp 
    50                  55                  60                  


Pro Ala Cys Gln Glu Ile Leu Phe Asp Pro Gln Xaa Xaa Ile Pro Glu 
65                  70                  75                  80  


Leu Phe Ala Ile Val Arg Gln Trp Val Pro Gln Val Gln His Lys Ile 
                85                  90                  95      


Asp Val Ile Gly Asn Glu Ile Leu Arg Arg Gly Cys His Val Asn Asp 
            100                 105                 110         


Arg Asp Gly Leu Xaa Asp Met Xaa Leu Leu His Tyr Ala Cys Lys Ala 
        115                 120                 125             


Gly Ala His Gly Val Gly Asp Pro Ala Ala Ala Val Arg Leu Ser Gln 
    130                 135                 140                 


Gln Leu Leu Ala Leu Gly Ala Asp Val Xaa Leu Arg Ser Arg Trp Xaa 
145                 150                 155                 160 


Asn Met Asn Ala Leu His Tyr Ala Ala Tyr Phe Asp Val Pro Asp Leu 
                165                 170                 175     


Val Arg Val Leu Leu Lys Gly Ala Arg Pro Arg Val Val Asn Ser Xaa 
            180                 185                 190         


Cys Ser Asp Phe Asn His Gly Ser Ala Leu His Ile Ala Ala Ser Ser 
        195                 200                 205             


Leu Cys Leu Gly Ala Ala Lys Cys Leu Leu Glu His Gly Ala Asn Pro 
    210                 215                 220                 


Ala Leu Arg Asn Arg Lys Gly Gln Val Pro Ala Glu Val Val Pro Asp 
225                 230                 235                 240 


Pro Met Asp Met Ser Leu Asp Lys Ala Glu Ala Ala Leu Val Ala Lys 
                245                 250                 255     


Glu Leu Arg Xaa Leu Leu Glu Glu Ala Val Pro Leu Ser Cys Ala Leu 
            260                 265                 270         


Pro Lys Val Xaa Leu Pro Asn Tyr Asp Asn Val Pro Gly Asn Leu Met 
        275                 280                 285             


Leu Ser Ala Leu Gly Leu Arg Leu Gly Asp Arg Val Leu Leu Asp Gly 
    290                 295                 300                 


Gln Lys Xaa Gly Xaa Leu Arg Phe Cys Gly Xaa Xaa Glu Phe Ala Ser 
305                 310                 315                 320 


Gly Gln Trp Val Gly Val Glu Leu Asp Glu Pro Glu Gly Lys Asn Asp 
                325                 330                 335     


Gly Ser Val Gly Gly Val Arg Tyr Phe Ile Cys Pro Pro Lys Gln Gly 
            340                 345                 350         


Leu Phe Ala Ser Val Ser Lys Ile Ser Lys Ala Val Asp Ala Pro Pro 
        355                 360                 365             


Ser Ser Val Xaa Ser Xaa Pro Arg Xaa Pro Arg Met Asp Phe Ser Arg 
    370                 375                 380                 


Val Xaa Gly Lys Gly Arg Arg Glu His Lys Gly Lys Lys Lys Xaa Pro 
385                 390                 395                 400 


Ser Ser Pro Ser Leu Gly Ser Leu Gln Gln Arg Asp Gly Ala Lys Ala 
                405                 410                 415     


Glu Val Gly Asp Gln Val Leu Val Ala Gly Gln Lys Gln Gly Ile Val 
            420                 425                 430         


Arg Phe Tyr Gly Lys Xaa Asp Phe Ala Pro Gly Tyr Trp Tyr Gly Ile 
        435                 440                 445             


Glu Leu Asp Gln Pro Xaa Gly Lys His Asp Gly Ser Val Phe Gly Val 
    450                 455                 460                 


Arg Tyr Phe Xaa Cys Pro Pro Arg His Gly Val Phe Ala Pro Ala Ser 
465                 470                 475                 480 


Arg Ile Gln Arg Ile Gly Gly Ser Xaa Asp Ser Pro Gly Asp Ser Val 
                485                 490                 495     


Gly Ala Lys Lys Val His Gln Val Xaa Met Xaa Gln Pro Lys Arg Xaa 
            500                 505                 510         


Phe Xaa Xaa Val Arg Xaa Pro Lys Asp Ile Ala Ser Glu Asn Ser Ile 
        515                 520                 525             


Ser Arg Leu Leu Phe Cys Cys Trp Phe Pro Trp Met Leu Arg Ala Glu 
    530                 535                 540                 


Met Gln Ser 
545         


<210> 6353
<211> 218
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<400> 6353
Ala Leu Leu Leu Ala Ser Tyr Phe Leu Leu Leu Xaa Ser Pro Glu Ala 
1               5                   10                  15      


Gln Asp Pro Gly Gly Glu Glu Glu Ala Glu Ser Ala Ala Arg Gln Pro 
            20                  25                  30          


Leu Ile Arg Xaa Glu Ala Pro Glu Ser Lys Pro Gly Ser Ser Ser Ser 
        35                  40                  45              


Leu Ser Leu Arg Glu Arg Trp Xaa Val Phe Lys Gly Leu Leu Trp Tyr 
    50                  55                  60                  


Ile Val Pro Leu Val Val Val Tyr Phe Ala Glu Tyr Phe Ile Asn Gln 
65                  70                  75                  80  


Gly Leu Phe Glu Leu Leu Phe Phe Trp Asn Xaa Ser Leu Ser His Ala 
                85                  90                  95      


Gln Gln Tyr Arg Trp Tyr Gln Met Leu Tyr Gln Ala Gly Val Phe Ala 
            100                 105                 110         


Ser Arg Ser Ser Leu Arg Cys Cys Arg Ile Arg Phe Xaa Trp Ala Leu 
        115                 120                 125             


Ala Leu Leu Gln Cys Leu Asn Leu Val Phe Leu Leu Ala Asp Val Trp 
    130                 135                 140                 


Phe Gly Phe Leu Pro Ser Ile Tyr Leu Val Phe Leu Ile Ile Leu Tyr 
145                 150                 155                 160 


Glu Gly Leu Leu Gly Gly Ala Ala Tyr Val Asn Xaa Phe His Asn Ile 
                165                 170                 175     


Ala Leu Glu Xaa Ser Asp Glu His Arg Glu Phe Ala Met Ala Ala Xaa 
            180                 185                 190         


Cys Ile Ser Asp Xaa Leu Gly Ile Ser Leu Ser Gly Leu Leu Ala Leu 
        195                 200                 205             


Pro Leu His Asp Phe Leu Cys Gln Leu Ser 
    210                 215             


<210> 6354
<211> 176
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 6354
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Cys Pro Arg Val Leu Val Ser 
        35                  40                  45              


Gly Ile Cys Ala Ala Gly Ser Phe Val Leu Val Ala Phe Ser His Ser 
    50                  55                  60                  


Val Gly Xaa Ser Leu Cys Gly Val Val Phe Ala Ser Ile Ser Ser Gly 
65                  70                  75                  80  


Leu Gly Glu Val Xaa Phe Leu Ser Leu Xaa Ala Phe Tyr Pro Arg Ala 
                85                  90                  95      


Val Ile Ser Trp Trp Ser Ser Gly Xaa Gly Gly Ala Gly Leu Leu Gly 
            100                 105                 110         


Ala Leu Ser Tyr Leu Gly Leu Xaa Gln Ala Gly Leu Ser Pro Gln Gln 
        115                 120                 125             


Xaa Leu Leu Ser Met Leu Gly Ile Pro Ala Leu Leu Leu Ala Ser Tyr 
    130                 135                 140                 


Phe Leu Leu Leu Xaa Ser Pro Glu Ala Gln Asp Pro Gly Gly Glu Glu 
145                 150                 155                 160 


Glu Ala Glu Ser Ala Ala Arg Gln Pro Leu Ile Arg Xaa Glu Ala Pro 
                165                 170                 175     


<210> 6355
<211> 269
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<400> 6355
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Cys Pro Arg Val Leu Val Ser 
        35                  40                  45              


Gly Ile Cys Ala Ala Gly Ser Phe Val Leu Val Ala Phe Ser His Ser 
    50                  55                  60                  


Val Gly Xaa Ser Leu Cys Gly Val Val Phe Ala Ser Ile Ser Ser Gly 
65                  70                  75                  80  


Leu Gly Glu Val Xaa Phe Leu Ser Leu Xaa Ala Phe Tyr Pro Arg Ala 
                85                  90                  95      


Val Ile Ser Trp Trp Ser Ser Gly Xaa Gly Gly Ala Gly Leu Leu Gly 
            100                 105                 110         


Ala Leu Ser Tyr Leu Gly Leu Xaa Gln Ala Gly Leu Ser Pro Gln Gln 
        115                 120                 125             


Xaa Leu Leu Ser Met Leu Gly Ile Pro Ala Leu Leu Leu Ala Ser Tyr 
    130                 135                 140                 


Phe Leu Leu Leu Xaa Ser Pro Glu Ala Gln Asp Pro Gly Gly Glu Glu 
145                 150                 155                 160 


Glu Ala Glu Ser Ala Ala Arg Gln Pro Leu Ile Arg Xaa Glu Ala Pro 
                165                 170                 175     


Glu Ser Lys Pro Gly Ser Ser Ser Ser Leu Ser Leu Arg Glu Arg Trp 
            180                 185                 190         


Xaa Val Phe Lys Gly Leu Leu Trp Tyr Ile Val Pro Leu Val Val Val 
        195                 200                 205             


Tyr Phe Ala Glu Tyr Phe Ile Asn Gln Gly Leu Phe Glu Leu Leu Phe 
    210                 215                 220                 


Phe Trp Asn Xaa Ser Leu Ser His Ala Gln Gln Tyr Arg Trp Tyr Gln 
225                 230                 235                 240 


Met Leu Tyr Gln Ala Gly Val Phe Ala Ser Arg Ser Ser Leu Arg Cys 
                245                 250                 255     


Cys Arg Ile Arg Phe Xaa Trp Ala Leu Ala Leu Leu Gln 
            260                 265                 


<210> 6356
<211> 105
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<400> 6356
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Cys Ser Trp Arg Xaa 
        35                  40                  45              


Ser Ser Pro His Ser Ser Ser Asn Cys Trp Leu Leu Leu Ala Phe Xaa 
    50                  55                  60                  


Cys Cys Pro Xaa Ala Pro Gly Phe Ser Ser Val Gly Phe Val Leu Leu 
65                  70                  75                  80  


Glu Ala Ser Ser Trp Leu Pro Phe Leu Ile Leu Trp Gly Pro Ala Cys 
                85                  90                  95      


Val Leu Phe Leu Val Ala His Ile Ser 
            100                 105 


<210> 6357
<211> 52
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<400> 6357
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Glu Ser Ser Gly Xaa 
        35                  40                  45              


Ile Ser Ala His 
    50          


<210> 6358
<211> 74
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<400> 6358
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Xaa Ser Gly Asn Gln Ser His 
65                  70                  


<210> 6359
<211> 414
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<400> 6359
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Xaa Ser Gly Asn Gln Ser His Ala Val Leu Leu Ala Asp 
65                  70                  75                  80  


Ile Leu Pro Xaa Leu Val Ile Lys Leu Leu Ala Pro Leu Gly Leu His 
                85                  90                  95      


Leu Leu Pro Tyr Ser Pro Arg Val Leu Val Ser Gly Ile Cys Ala Ala 
            100                 105                 110         


Gly Ser Phe Val Leu Val Ala Phe Ser His Ser Val Gly Xaa Ser Leu 
        115                 120                 125             


Cys Gly Val Val Phe Ala Ser Ile Ser Ser Gly Leu Gly Glu Val Xaa 
    130                 135                 140                 


Phe Leu Ser Leu Xaa Ala Phe Tyr Pro Arg Ala Val Ile Ser Trp Trp 
145                 150                 155                 160 


Ser Ser Gly Xaa Gly Gly Ala Gly Leu Leu Gly Ala Leu Ser Tyr Leu 
                165                 170                 175     


Gly Leu Xaa Gln Ala Gly Leu Ser Pro Gln Gln Xaa Leu Leu Ser Met 
            180                 185                 190         


Leu Gly Ile Pro Ala Leu Leu Leu Ala Ser Tyr Phe Leu Leu Leu Xaa 
        195                 200                 205             


Ser Pro Glu Ala Gln Asp Pro Gly Gly Glu Glu Glu Ala Glu Ser Ala 
    210                 215                 220                 


Ala Arg Gln Pro Leu Ile Arg Xaa Glu Ala Pro Glu Ser Lys Pro Gly 
225                 230                 235                 240 


Ser Ser Ser Ser Leu Ser Leu Arg Glu Arg Trp Xaa Val Phe Lys Gly 
                245                 250                 255     


Leu Leu Trp Tyr Ile Val Pro Leu Val Val Val Tyr Phe Ala Glu Tyr 
            260                 265                 270         


Phe Ile Asn Gln Gly Leu Phe Glu Leu Leu Phe Phe Trp Asn Xaa Ser 
        275                 280                 285             


Leu Ser His Ala Gln Gln Tyr Arg Trp Tyr Gln Met Leu Tyr Gln Ala 
    290                 295                 300                 


Gly Val Phe Ala Ser Arg Ser Ser Leu Arg Cys Cys Arg Ile Arg Phe 
305                 310                 315                 320 


Xaa Trp Ala Leu Ala Leu Leu Gln Cys Leu Asn Leu Val Phe Leu Leu 
                325                 330                 335     


Ala Asp Val Trp Phe Gly Phe Leu Pro Ser Ile Tyr Leu Val Phe Leu 
            340                 345                 350         


Ile Ile Leu Tyr Glu Gly Leu Leu Gly Gly Ala Ala Tyr Val Asn Xaa 
        355                 360                 365             


Phe His Asn Ile Ala Leu Glu Xaa Ser Asp Glu His Arg Glu Phe Ala 
    370                 375                 380                 


Met Ala Ala Xaa Cys Ile Ser Asp Xaa Leu Gly Ile Ser Leu Ser Gly 
385                 390                 395                 400 


Leu Leu Ala Leu Pro Leu His Asp Phe Leu Cys Gln Leu Ser 
                405                 410                 


<210> 6360
<211> 82
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<400> 6360
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Xaa Ser Gly Asn Gln Ser His Leu Phe Leu Val Ala His 
65                  70                  75                  80  


Ile Ser 
        


<210> 6361
<211> 167
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<400> 6361
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Xaa Ser Gly Asn Gln Ser His Pro Pro Gly Ser Arg Gln 
65                  70                  75                  80  


Trp Asp Leu Cys Cys Trp Lys Leu Arg Pro Gly Cys Leu Phe Ser Phe 
                85                  90                  95      


Cys Gly Asp Gln Pro Val Cys Tyr Phe Leu Leu Leu Xaa Ser Pro Glu 
            100                 105                 110         


Ala Gln Asp Pro Gly Gly Glu Glu Glu Ala Glu Ser Ala Ala Arg Gln 
        115                 120                 125             


Pro Leu Ile Arg Xaa Glu Ala Pro Glu Ser Lys Pro Gly Ser Ser Ser 
    130                 135                 140                 


Ser Leu Ser Leu Arg Glu Arg Trp Xaa Val Phe Lys Gly Leu Leu Trp 
145                 150                 155                 160 


Tyr Ile Val Pro Leu Val Val 
                165         


<210> 6362
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 6362
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Xaa Ser Gly Asn Gln Ser His Val Asp Pro Gly Pro Xaa 
65                  70                  75                  80  


Pro Ile Pro His Asn Ser Ser Ser Arg Phe Asp Cys Asn Ser Val Ser 
                85                  90                  95      


Xaa Ala Ala Val Leu Leu Ala Asp Ile Leu Pro Xaa Leu Val Ile Lys 
            100                 105                 110         


Leu Leu Ala Pro Leu Gly Leu His Leu Leu Pro Tyr Ser Pro Arg Val 
        115                 120                 125             


Leu Val Ser Gly Ile Cys Ala Ala Gly Ser Phe Val Leu Val Ala Phe 
    130                 135                 140                 


Ser His Ser Val Gly Xaa Ser Leu Cys Ala Ile Ser Cys Cys Ser His 
145                 150                 155                 160 


Leu Leu Arg Pro Arg Xaa Leu Glu Gly Lys Lys Lys Gln Arg Ala Gln 
                165                 170                 175     


Pro Gly Ser Pro Ser 
            180     


<210> 6363
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 6363
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Xaa Ser Gly Asn Gln Ser His Val Asp Pro Gly Pro Xaa 
65                  70                  75                  80  


Pro Ile Pro His Asn Ser Ser Ser Arg Phe Asp Cys Asn Ser Val Ser 
                85                  90                  95      


Xaa Ala Ala Val Leu Leu Ala Asp Ile Leu Pro Xaa Leu Val Ile Lys 
            100                 105                 110         


Leu Leu Ala Pro Leu Gly Leu His Leu Leu Pro Tyr Ser Pro Arg Val 
        115                 120                 125             


Leu Val Ser Gly Ile Cys Ala Ala Gly Ser Phe Val Leu Val Ala Phe 
    130                 135                 140                 


Ser His Ser Val Gly Xaa Ser Leu Cys Gly Pro 
145                 150                 155 


<210> 6364
<211> 253
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<400> 6364
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Xaa Ser Gly Asn Gln Ser His Val Asp Pro Gly Pro Xaa 
65                  70                  75                  80  


Pro Ile Pro His Asn Ser Ser Ser Arg Phe Asp Cys Asn Ser Val Ser 
                85                  90                  95      


Xaa Ala Ala Val Leu Leu Ala Asp Ile Leu Pro Xaa Leu Val Ile Lys 
            100                 105                 110         


Leu Leu Ala Pro Leu Gly Leu His Leu Leu Pro Tyr Ser Pro Arg Val 
        115                 120                 125             


Leu Val Ser Gly Ile Cys Ala Ala Gly Ser Phe Val Leu Val Ala Phe 
    130                 135                 140                 


Ser His Ser Val Gly Xaa Ser Leu Cys Gly Ser Ser Ser Ser Leu Ser 
145                 150                 155                 160 


Leu Arg Glu Arg Trp Xaa Val Phe Lys Gly Leu Leu Trp Tyr Ile Val 
                165                 170                 175     


Pro Leu Val Val Val Tyr Phe Ala Glu Tyr Phe Ile Asn Gln Gly Leu 
            180                 185                 190         


Phe Glu Leu Leu Phe Phe Trp Asn Xaa Ser Leu Ser His Ala Gln Gln 
        195                 200                 205             


Tyr Arg Trp Tyr Gln Met Leu Tyr Gln Ala Gly Val Phe Ala Ser Arg 
    210                 215                 220                 


Ser Ser Leu Arg Cys Cys Arg Ile Arg Phe Xaa Trp Ala Leu Ala Leu 
225                 230                 235                 240 


Leu Gln Met Glu Ser Arg Ser Val Ala Gln Ala Gly Met 
                245                 250             


<210> 6365
<211> 341
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<400> 6365
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Xaa Ser Gly Asn Gln Ser His Val Asp Pro Gly Pro Xaa 
65                  70                  75                  80  


Pro Ile Pro His Asn Ser Ser Ser Arg Phe Asp Cys Asn Ser Val Ser 
                85                  90                  95      


Xaa Ala Ala Val Leu Leu Ala Asp Ile Leu Pro Xaa Leu Val Ile Lys 
            100                 105                 110         


Leu Leu Ala Pro Leu Gly Leu His Leu Leu Pro Tyr Ser Pro Arg Val 
        115                 120                 125             


Leu Val Ser Gly Ile Cys Ala Ala Gly Ser Phe Val Leu Val Ala Phe 
    130                 135                 140                 


Ser His Ser Val Gly Xaa Ser Leu Cys Gly Val Val Phe Ala Ser Ile 
145                 150                 155                 160 


Ser Ser Gly Leu Gly Glu Val Xaa Phe Leu Ser Leu Xaa Ala Phe Tyr 
                165                 170                 175     


Pro Arg Ala Val Ile Ser Trp Trp Ser Ser Gly Xaa Gly Gly Ala Gly 
            180                 185                 190         


Leu Leu Gly Ala Leu Ser Tyr Leu Gly Leu Xaa Gln Ala Gly Leu Ser 
        195                 200                 205             


Pro Gln Gln Xaa Leu Leu Ser Met Leu Gly Ile Pro Ala Leu Leu Leu 
    210                 215                 220                 


Ala Ser Tyr Phe Leu Leu Leu Xaa Ser Pro Glu Ala Gln Asp Pro Gly 
225                 230                 235                 240 


Gly Glu Glu Glu Ala Glu Ser Ala Ala Arg Gln Pro Leu Ile Arg Xaa 
                245                 250                 255     


Glu Ala Pro Glu Ser Lys Pro Gly Ser Ser Ser Ser Leu Ser Leu Arg 
            260                 265                 270         


Glu Arg Trp Xaa Val Phe Lys Gly Leu Leu Trp Tyr Ile Val Pro Leu 
        275                 280                 285             


Val Val Val Tyr Phe Ala Glu Tyr Phe Ile Asn Gln Gly Leu Xaa Ser 
    290                 295                 300                 


Asp Glu His Arg Glu Phe Ala Met Ala Ala Xaa Cys Ile Ser Asp Xaa 
305                 310                 315                 320 


Leu Gly Ile Ser Leu Ser Gly Leu Leu Ala Leu Pro Leu His Asp Phe 
                325                 330                 335     


Leu Cys Gln Leu Ser 
            340     


<210> 6366
<211> 363
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<400> 6366
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Xaa Ser Gly Asn Gln Ser His Val Asp Pro Gly Pro Xaa 
65                  70                  75                  80  


Pro Ile Pro His Asn Ser Ser Ser Arg Phe Asp Cys Asn Ser Val Ser 
                85                  90                  95      


Xaa Ala Ala Val Leu Leu Ala Asp Ile Leu Pro Xaa Leu Val Ile Lys 
            100                 105                 110         


Leu Leu Ala Pro Leu Gly Leu His Leu Leu Pro Tyr Ser Pro Arg Val 
        115                 120                 125             


Leu Val Ser Gly Ile Cys Ala Ala Gly Ser Phe Val Leu Val Ala Phe 
    130                 135                 140                 


Ser His Ser Val Gly Xaa Ser Leu Cys Gly Val Val Phe Ala Ser Ile 
145                 150                 155                 160 


Ser Ser Gly Leu Gly Glu Val Xaa Phe Leu Ser Leu Xaa Ala Phe Tyr 
                165                 170                 175     


Pro Arg Ala Val Ile Ser Trp Trp Ser Ser Gly Xaa Gly Gly Ala Gly 
            180                 185                 190         


Leu Leu Gly Ala Leu Ser Tyr Leu Gly Leu Xaa Gln Ala Gly Leu Ser 
        195                 200                 205             


Pro Gln Gln Xaa Leu Leu Ser Met Leu Gly Ile Pro Ala Leu Leu Leu 
    210                 215                 220                 


Ala Ser Tyr Phe Leu Leu Leu Xaa Ser Pro Glu Ala Gln Asp Pro Gly 
225                 230                 235                 240 


Gly Glu Glu Glu Ala Glu Ser Ala Ala Arg Gln Pro Leu Ile Arg Xaa 
                245                 250                 255     


Glu Ala Pro Glu Ser Lys Pro Gly Ser Ser Ser Ser Leu Ser Leu Arg 
            260                 265                 270         


Glu Arg Trp Xaa Val Phe Lys Gly Leu Leu Trp Tyr Ile Val Pro Leu 
        275                 280                 285             


Val Val Val Tyr Phe Ala Glu Tyr Phe Ile Asn Gln Gly Leu Phe Glu 
    290                 295                 300                 


Leu Leu Phe Phe Trp Asn Xaa Ser Leu Ser His Ala Gln Gln Tyr Arg 
305                 310                 315                 320 


Trp Tyr Gln Met Leu Tyr Gln Ala Gly Val Phe Ala Ser Arg Ser Ser 
                325                 330                 335     


Leu Arg Cys Cys Arg Ile Arg Phe Xaa Trp Ala Leu Ala Leu Leu Gln 
            340                 345                 350         


Met Glu Ser Arg Ser Val Ala Gln Ala Gly Met 
        355                 360             


<210> 6367
<211> 370
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<400> 6367
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Xaa Ser Gly Asn Gln Ser His Val Asp Pro Gly Pro Xaa 
65                  70                  75                  80  


Pro Ile Pro His Asn Ser Ser Ser Arg Phe Asp Cys Asn Ser Val Ser 
                85                  90                  95      


Xaa Ala Ala Val Leu Leu Ala Asp Ile Leu Pro Xaa Leu Val Ile Lys 
            100                 105                 110         


Leu Leu Ala Pro Leu Gly Leu His Leu Leu Pro Tyr Ser Pro Arg Val 
        115                 120                 125             


Leu Val Ser Gly Ile Cys Ala Ala Gly Ser Phe Val Leu Val Ala Phe 
    130                 135                 140                 


Ser His Ser Val Gly Xaa Ser Leu Cys Gly Val Val Phe Ala Ser Ile 
145                 150                 155                 160 


Ser Ser Gly Leu Gly Glu Val Xaa Phe Leu Ser Leu Xaa Ala Phe Tyr 
                165                 170                 175     


Pro Arg Ala Val Ile Ser Trp Trp Ser Ser Gly Xaa Gly Gly Ala Gly 
            180                 185                 190         


Leu Leu Gly Ala Leu Ser Tyr Leu Gly Leu Xaa Gln Ala Gly Leu Ser 
        195                 200                 205             


Pro Gln Gln Xaa Leu Leu Ser Met Leu Gly Ile Pro Ala Leu Leu Leu 
    210                 215                 220                 


Ala Ser Tyr Phe Leu Leu Leu Xaa Ser Pro Glu Ala Gln Asp Pro Gly 
225                 230                 235                 240 


Gly Glu Glu Glu Ala Glu Ser Ala Ala Arg Gln Pro Leu Ile Arg Xaa 
                245                 250                 255     


Glu Ala Pro Glu Ser Lys Pro Gly Ser Ser Ser Ser Leu Ser Leu Arg 
            260                 265                 270         


Glu Arg Trp Xaa Val Phe Lys Val Arg Met Met Ala Gly Phe Glu Leu 
        275                 280                 285             


Leu Phe Phe Trp Asn Xaa Ser Leu Ser His Ala Gln Gln Tyr Arg Trp 
    290                 295                 300                 


Tyr Gln Met Leu Tyr Gln Ala Gly Val Phe Ala Ser Arg Ser Ser Leu 
305                 310                 315                 320 


Arg Cys Cys Arg Ile Arg Phe Xaa Trp Ala Leu Ala Leu Leu Gln Met 
                325                 330                 335     


Glu Ser Cys Ser Val Xaa Arg Leu Glu Cys Ser Asp Ala Val Ser Ala 
            340                 345                 350         


His Cys Ser Leu Arg Phe Trp Val Gln Ala Ile Leu Leu Pro Gln Pro 
        355                 360                 365             


Pro Lys 
    370 


<210> 6368
<211> 421
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<400> 6368
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Xaa Ser Gly Asn Gln Ser His Val Asp Pro Gly Pro Xaa 
65                  70                  75                  80  


Pro Ile Pro His Asn Ser Ser Ser Arg Phe Asp Cys Asn Ser Val Ser 
                85                  90                  95      


Xaa Ala Ala Val Leu Leu Ala Asp Ile Leu Pro Xaa Leu Val Ile Lys 
            100                 105                 110         


Leu Leu Ala Pro Leu Gly Leu His Leu Leu Pro Tyr Ser Pro Arg Val 
        115                 120                 125             


Leu Val Ser Gly Ile Cys Ala Ala Gly Ser Phe Val Leu Val Ala Phe 
    130                 135                 140                 


Ser His Ser Val Gly Xaa Ser Leu Cys Gly Val Val Phe Ala Ser Ile 
145                 150                 155                 160 


Ser Ser Gly Leu Gly Glu Val Xaa Phe Leu Ser Leu Xaa Ala Phe Tyr 
                165                 170                 175     


Pro Arg Ala Val Ile Ser Trp Trp Ser Ser Gly Xaa Gly Gly Ala Gly 
            180                 185                 190         


Leu Leu Gly Ala Leu Ser Tyr Leu Gly Leu Xaa Gln Ala Gly Leu Ser 
        195                 200                 205             


Pro Gln Gln Xaa Leu Leu Ser Met Leu Gly Ile Pro Ala Leu Leu Leu 
    210                 215                 220                 


Ala Ser Tyr Phe Leu Leu Leu Xaa Ser Pro Glu Ala Gln Asp Pro Gly 
225                 230                 235                 240 


Gly Glu Glu Glu Ala Glu Ser Ala Ala Arg Gln Pro Leu Ile Arg Xaa 
                245                 250                 255     


Glu Ala Pro Glu Ser Lys Pro Gly Ser Ser Ser Ser Leu Ser Leu Arg 
            260                 265                 270         


Glu Arg Trp Xaa Val Phe Lys Val Arg Met Met Ala Gly Phe Glu Leu 
        275                 280                 285             


Leu Phe Phe Trp Asn Xaa Ser Leu Ser His Ala Gln Gln Tyr Arg Trp 
    290                 295                 300                 


Tyr Gln Met Leu Tyr Gln Ala Gly Val Phe Ala Ser Arg Ser Ser Leu 
305                 310                 315                 320 


Arg Cys Cys Arg Ile Arg Phe Xaa Trp Ala Leu Ala Leu Leu Gln Cys 
                325                 330                 335     


Leu Asn Leu Val Phe Leu Leu Ala Asp Val Trp Phe Gly Phe Leu Pro 
            340                 345                 350         


Ser Ile Tyr Leu Val Phe Leu Ile Ile Leu Tyr Glu Gly Leu Leu Gly 
        355                 360                 365             


Gly Ala Ala Tyr Val Asn Xaa Phe His Asn Ile Ala Leu Glu Xaa Ser 
    370                 375                 380                 


Asp Glu His Arg Glu Phe Ala Met Ala Ala Xaa Cys Ile Ser Asp Xaa 
385                 390                 395                 400 


Leu Gly Ile Ser Leu Ser Gly Leu Leu Ala Leu Pro Leu His Asp Phe 
                405                 410                 415     


Leu Cys Gln Leu Ser 
            420     


<210> 6369
<211> 438
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<400> 6369
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Xaa Ser Gly Asn Gln Ser His Val Asp Pro Gly Pro Xaa 
65                  70                  75                  80  


Pro Ile Pro His Asn Ser Ser Ser Arg Phe Asp Cys Asn Ser Val Ser 
                85                  90                  95      


Xaa Ala Ala Val Leu Leu Ala Asp Ile Leu Pro Xaa Leu Val Ile Lys 
            100                 105                 110         


Leu Leu Ala Pro Leu Gly Leu His Leu Leu Pro Tyr Ser Pro Arg Val 
        115                 120                 125             


Leu Val Ser Gly Ile Cys Ala Ala Gly Ser Phe Val Leu Val Ala Phe 
    130                 135                 140                 


Ser His Ser Val Gly Xaa Ser Leu Cys Gly Val Val Phe Ala Ser Ile 
145                 150                 155                 160 


Ser Ser Gly Leu Gly Glu Val Xaa Phe Leu Ser Leu Xaa Ala Phe Tyr 
                165                 170                 175     


Pro Arg Ala Val Ile Ser Trp Trp Ser Ser Gly Xaa Gly Gly Ala Gly 
            180                 185                 190         


Leu Leu Gly Ala Leu Ser Tyr Leu Gly Leu Xaa Gln Ala Gly Leu Ser 
        195                 200                 205             


Pro Gln Gln Xaa Leu Leu Ser Met Leu Gly Ile Pro Ala Leu Leu Leu 
    210                 215                 220                 


Ala Ser Tyr Phe Leu Leu Leu Xaa Ser Pro Glu Ala Gln Asp Pro Gly 
225                 230                 235                 240 


Gly Glu Glu Glu Ala Glu Ser Ala Ala Arg Gln Pro Leu Ile Arg Xaa 
                245                 250                 255     


Glu Ala Pro Glu Ser Lys Pro Gly Ser Ser Ser Ser Leu Ser Leu Arg 
            260                 265                 270         


Glu Arg Trp Xaa Val Phe Lys Gly Leu Leu Trp Tyr Ile Val Pro Leu 
        275                 280                 285             


Val Val Val Tyr Phe Ala Glu Tyr Phe Ile Asn Gln Gly Leu Phe Glu 
    290                 295                 300                 


Leu Leu Phe Phe Trp Asn Xaa Ser Leu Ser His Ala Gln Gln Tyr Arg 
305                 310                 315                 320 


Trp Tyr Gln Met Leu Tyr Gln Ala Gly Val Phe Ala Ser Arg Ser Ser 
                325                 330                 335     


Leu Arg Cys Cys Arg Ile Arg Phe Xaa Trp Ala Leu Ala Leu Leu Gln 
            340                 345                 350         


Cys Leu Asn Leu Val Phe Leu Leu Ala Asp Val Trp Phe Gly Phe Leu 
        355                 360                 365             


Pro Ser Ile Tyr Leu Val Phe Leu Ile Ile Leu Tyr Glu Gly Leu Leu 
    370                 375                 380                 


Gly Gly Ala Ala Tyr Val Asn Xaa Phe His Asn Ile Ala Leu Glu Xaa 
385                 390                 395                 400 


Ser Asp Glu His Arg Glu Phe Ala Met Ala Ala Xaa Cys Ile Ser Asp 
                405                 410                 415     


Xaa Leu Gly Ile Ser Leu Ser Gly Leu Leu Ala Leu Pro Leu His Asp 
            420                 425                 430         


Phe Leu Cys Gln Leu Ser 
        435             


<210> 6370
<211> 390
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<400> 6370
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Xaa Ser Gly Asn Gln Ser His Val Asp Pro Gly Pro Xaa 
65                  70                  75                  80  


Pro Ile Pro His Asn Ser Ser Ser Arg Phe Asp Cys Asn Ser Val Ser 
                85                  90                  95      


Xaa Ala Ala Val Leu Leu Ala Asp Ile Leu Pro Xaa Leu Val Ile Lys 
            100                 105                 110         


Leu Leu Ala Pro Leu Gly Leu His Leu Leu Pro Tyr Ser Pro Arg Val 
        115                 120                 125             


Leu Val Ser Gly Ile Cys Ala Ala Gly Ser Phe Val Leu Val Ala Phe 
    130                 135                 140                 


Ser His Ser Val Gly Xaa Ser Leu Cys Gly Val Val Phe Ala Ser Ile 
145                 150                 155                 160 


Ser Ser Gly Leu Gly Glu Val Xaa Phe Leu Ser Leu Xaa Ala Phe Tyr 
                165                 170                 175     


Pro Ser Tyr Phe Leu Leu Leu Xaa Ser Pro Glu Ala Gln Asp Pro Gly 
            180                 185                 190         


Gly Glu Glu Glu Ala Glu Ser Ala Ala Arg Gln Pro Leu Ile Arg Xaa 
        195                 200                 205             


Glu Ala Pro Glu Ser Lys Pro Gly Ser Ser Ser Ser Leu Ser Leu Arg 
    210                 215                 220                 


Glu Arg Trp Xaa Val Phe Lys Gly Leu Leu Trp Tyr Ile Val Pro Leu 
225                 230                 235                 240 


Val Val Val Tyr Phe Ala Glu Tyr Phe Ile Asn Gln Gly Leu Phe Glu 
                245                 250                 255     


Leu Leu Phe Phe Trp Asn Xaa Ser Leu Ser His Ala Gln Gln Tyr Arg 
            260                 265                 270         


Trp Tyr Gln Met Leu Tyr Gln Ala Gly Val Phe Ala Ser Arg Ser Ser 
        275                 280                 285             


Leu Arg Cys Cys Arg Ile Arg Phe Xaa Trp Ala Leu Ala Leu Leu Gln 
    290                 295                 300                 


Cys Leu Asn Leu Val Phe Leu Leu Ala Asp Val Trp Phe Gly Phe Leu 
305                 310                 315                 320 


Pro Ser Ile Tyr Leu Val Phe Leu Ile Ile Leu Tyr Glu Gly Leu Leu 
                325                 330                 335     


Gly Gly Ala Ala Tyr Val Asn Xaa Phe His Asn Ile Ala Leu Glu Xaa 
            340                 345                 350         


Ser Asp Glu His Arg Glu Phe Ala Met Ala Ala Xaa Cys Ile Ser Asp 
        355                 360                 365             


Xaa Leu Gly Ile Ser Leu Ser Gly Leu Leu Ala Leu Pro Leu His Asp 
    370                 375                 380                 


Phe Leu Cys Gln Leu Ser 
385                 390 


<210> 6371
<211> 177
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<400> 6371
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Xaa Ser Gly Asn Gln Ser His Val Asp Pro Gly Pro Xaa 
65                  70                  75                  80  


Pro Ile Pro His Asn Ser Ser Ser Arg Phe Asp Cys Asn Ser Val Ser 
                85                  90                  95      


Xaa Ala Pro Pro Gly Ser Arg Gln Trp Asp Leu Cys Cys Trp Lys Leu 
            100                 105                 110         


Arg Pro Gly Cys Leu Phe Ser Phe Cys Gly Asp Gln Pro Val Cys Tyr 
        115                 120                 125             


Phe Leu Leu Leu Xaa Ser Pro Glu Ala Gln Asp Pro Gly Gly Glu Glu 
    130                 135                 140                 


Glu Ala Glu Ser Ala Ala Arg Gln Pro Leu Ile Arg Xaa Glu Ala Pro 
145                 150                 155                 160 


Glu Ser Lys Pro Gly Ser Ser Ser Ser Leu Ser Leu Arg Glu Arg Trp 
                165                 170                 175     


Xaa 
    


<210> 6372
<211> 339
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<400> 6372
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Xaa Ser Gly Asn Gln Ser His Val Asp Pro Gly Pro Xaa 
65                  70                  75                  80  


Pro Ile Pro His Asn Ser Ser Ser Arg Phe Asp Cys Asn Ser Val Ser 
                85                  90                  95      


Xaa Ala Pro Pro Gly Ser Arg Gln Trp Asp Leu Cys Cys Trp Lys Leu 
            100                 105                 110         


Arg Pro Gly Cys Leu Phe Ser Phe Cys Gly Asp Gln Pro Val Cys Tyr 
        115                 120                 125             


Phe Leu Leu Leu Xaa Ser Pro Glu Ala Gln Asp Pro Gly Gly Glu Glu 
    130                 135                 140                 


Glu Ala Glu Ser Ala Ala Arg Gln Pro Leu Ile Arg Xaa Glu Ala Pro 
145                 150                 155                 160 


Glu Ser Lys Pro Gly Ser Ser Ser Ser Leu Ser Leu Arg Glu Arg Trp 
                165                 170                 175     


Xaa Val Phe Lys Gly Leu Leu Trp Tyr Ile Val Pro Leu Val Val Val 
            180                 185                 190         


Tyr Phe Ala Glu Tyr Phe Ile Asn Gln Gly Leu Phe Glu Leu Leu Phe 
        195                 200                 205             


Phe Trp Asn Xaa Ser Leu Ser His Ala Gln Gln Tyr Arg Trp Tyr Gln 
    210                 215                 220                 


Met Leu Tyr Gln Ala Gly Val Phe Ala Ser Arg Ser Ser Leu Arg Cys 
225                 230                 235                 240 


Cys Arg Ile Arg Phe Xaa Trp Ala Leu Ala Leu Leu Gln Cys Leu Asn 
                245                 250                 255     


Leu Val Phe Leu Leu Ala Asp Val Trp Phe Gly Phe Leu Pro Ser Ile 
            260                 265                 270         


Tyr Leu Val Phe Leu Ile Ile Leu Tyr Glu Gly Leu Leu Gly Gly Ala 
        275                 280                 285             


Ala Tyr Val Asn Xaa Phe His Asn Ile Ala Leu Glu Xaa Ser Asp Glu 
    290                 295                 300                 


His Arg Glu Phe Ala Met Ala Ala Xaa Cys Ile Ser Asp Xaa Leu Gly 
305                 310                 315                 320 


Ile Ser Leu Ser Gly Leu Leu Ala Leu Pro Leu His Asp Phe Leu Cys 
                325                 330                 335     


Gln Leu Ser 
            


<210> 6373
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<400> 6373
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Xaa Ser Gly Asn Gln Ser His Val Asp Pro Gly Pro Xaa 
65                  70                  75                  80  


Pro Ile Pro His Asn Ser Ser Ser Arg Phe Asp Cys Asn Ser Val Ser 
                85                  90                  95      


Xaa Ala Pro Pro Gly Ser Arg Gln Trp Asp Leu Cys Cys Trp Lys Leu 
            100                 105                 110         


Arg Pro Gly Cys Leu Phe Ser Phe Cys Gly Asp Gln Pro Val Trp Cys 
        115                 120                 125             


Gly Leu Arg 
    130     


<210> 6374
<211> 228
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<400> 6374
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Tyr Ser Arg Pro Pro Ser Trp Asn Asp His Leu Trp Leu Ala Ala 
            20                  25                  30          


His Leu Arg Gly Met Arg Ala Asp Ser Ala Pro Gly Gly His Ala Arg 
        35                  40                  45              


Ser Gly Arg Ala Pro Glu Ser Arg Trp Gly Ser Cys Pro Leu Leu Ala 
    50                  55                  60                  


Leu Pro Gly Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp 
65                  70                  75                  80  


His Gln Gly Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly 
                85                  90                  95      


Leu Cys Asn Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp 
            100                 105                 110         


Ile Leu Ser His Lys Arg Xaa Ser Gly Asn Gln Ser His Val Asp Pro 
        115                 120                 125             


Gly Pro Xaa Pro Ile Pro His Asn Ser Ser Ser Arg Phe Asp Cys Asn 
    130                 135                 140                 


Ser Val Ser Xaa Ala Ala Val Leu Leu Ala Asp Ile Leu Pro Xaa Leu 
145                 150                 155                 160 


Val Ile Lys Leu Leu Ala Pro Leu Gly Leu His Leu Leu Pro Tyr Ser 
                165                 170                 175     


Pro Arg Val Leu Val Ser Gly Ile Cys Ala Ala Gly Ser Phe Val Leu 
            180                 185                 190         


Val Ala Phe Ser His Ser Val Gly Xaa Ser Leu Cys Gly Val Val Phe 
        195                 200                 205             


Ala Ser Ile Ser Ser Gly Leu Gly Glu Val Xaa Phe Leu Ser Leu Xaa 
    210                 215                 220                 


Ala Phe Tyr Pro 
225             


<210> 6375
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 6375
Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Tyr Ser Arg Pro Pro Ser Trp Asn Asp His Leu Trp Leu Ala Ala 
            20                  25                  30          


His Leu Arg Gly Met Arg Ala Asp Ser Ala Pro Gly Gly His Ala Arg 
        35                  40                  45              


Ser Gly Arg Ala Pro Glu Ser Arg Trp Gly Ser Cys Pro Leu Leu Ala 
    50                  55                  60                  


Leu Pro Gly Glu Glu Xaa Val Pro Glu Pro Arg Leu Pro Leu Leu Asp 
65                  70                  75                  80  


His Gln Gly Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly 
                85                  90                  95      


Leu Cys Asn Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp 
            100                 105                 110         


Ile Leu Ser His Lys Arg Xaa Ser Gly Asn Gln Ser His Val Asp Pro 
        115                 120                 125             


Gly Pro Xaa Pro Ile Pro His Asn Ser Ser Ser Arg Phe Asp Cys Asn 
    130                 135                 140                 


Ser Val Ser Xaa Ala Pro Pro Gly Ser Arg Gln Trp Asp Leu Cys Cys 
145                 150                 155                 160 


Trp Lys Leu Arg Pro Gly Cys Leu Phe Ser Phe Cys Gly Asp Gln Pro 
                165                 170                 175     


Val Trp Cys Gly Leu Arg 
            180         


<210> 6376
<211> 53
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<400> 6376
Met Leu Ser Ala Ala His Asp Ile Leu Ser His Lys Arg Xaa Ser Gly 
1               5                   10                  15      


Asn Gln Ser His Pro Pro Gly Ser Arg Gln Trp Asp Leu Cys Cys Trp 
            20                  25                  30          


Lys Leu Arg Pro Gly Cys Leu Phe Ser Phe Cys Gly Asp Gln Pro Val 
        35                  40                  45              


Trp Cys Gly Leu Arg 
    50              


<210> 6377
<211> 384
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<400> 6377
Met Leu Ser Ala Ala His Asp Ile Leu Ser His Lys Arg Xaa Ser Gly 
1               5                   10                  15      


Asn Gln Ser His Val Asp Pro Gly Pro Xaa Pro Ile Pro His Asn Ser 
            20                  25                  30          


Ser Ser Arg Phe Asp Cys Asn Ser Val Ser Xaa Ala Ala Val Leu Leu 
        35                  40                  45              


Ala Asp Ile Leu Pro Xaa Leu Val Ile Lys Leu Leu Ala Pro Leu Gly 
    50                  55                  60                  


Leu His Leu Leu Pro Tyr Ser Pro Arg Val Leu Val Ser Gly Ile Cys 
65                  70                  75                  80  


Ala Ala Gly Ser Phe Val Leu Val Ala Phe Ser His Ser Val Gly Xaa 
                85                  90                  95      


Ser Leu Cys Gly Val Val Phe Ala Ser Ile Ser Ser Gly Leu Gly Glu 
            100                 105                 110         


Val Xaa Phe Leu Ser Leu Xaa Ala Phe Tyr Pro Arg Ala Val Ile Ser 
        115                 120                 125             


Trp Trp Ser Ser Gly Xaa Gly Gly Ala Gly Leu Leu Gly Ala Leu Ser 
    130                 135                 140                 


Tyr Leu Gly Leu Xaa Gln Ala Gly Leu Ser Pro Gln Gln Xaa Leu Leu 
145                 150                 155                 160 


Ser Met Leu Gly Ile Pro Ala Leu Leu Leu Ala Ser Tyr Phe Leu Leu 
                165                 170                 175     


Leu Xaa Ser Pro Glu Ala Gln Asp Pro Gly Gly Glu Glu Glu Ala Glu 
            180                 185                 190         


Ser Ala Ala Arg Gln Pro Leu Ile Arg Xaa Glu Ala Pro Glu Ser Lys 
        195                 200                 205             


Pro Gly Ser Ser Ser Ser Leu Ser Leu Arg Glu Arg Trp Xaa Val Phe 
    210                 215                 220                 


Lys Gly Leu Leu Trp Tyr Ile Val Pro Leu Val Val Val Tyr Phe Ala 
225                 230                 235                 240 


Glu Tyr Phe Ile Asn Gln Gly Leu Phe Glu Leu Leu Phe Phe Trp Asn 
                245                 250                 255     


Xaa Ser Leu Ser His Ala Gln Gln Tyr Arg Trp Tyr Gln Met Leu Tyr 
            260                 265                 270         


Gln Ala Gly Val Phe Ala Ser Arg Ser Ser Leu Arg Cys Cys Arg Ile 
        275                 280                 285             


Arg Phe Xaa Trp Ala Leu Ala Leu Leu Gln Cys Leu Asn Leu Val Phe 
    290                 295                 300                 


Leu Leu Ala Asp Val Trp Phe Gly Phe Leu Pro Ser Ile Tyr Leu Val 
305                 310                 315                 320 


Phe Leu Ile Ile Leu Tyr Glu Gly Leu Leu Gly Gly Ala Ala Tyr Val 
                325                 330                 335     


Asn Xaa Phe His Asn Ile Ala Leu Glu Xaa Ser Asp Glu His Arg Glu 
            340                 345                 350         


Phe Ala Met Ala Ala Xaa Cys Ile Ser Asp Xaa Leu Gly Ile Ser Leu 
        355                 360                 365             


Ser Gly Leu Leu Ala Leu Pro Leu His Asp Phe Leu Cys Gln Leu Ser 
    370                 375                 380                 


<210> 6378
<211> 336
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<400> 6378
Met Leu Ser Ala Ala His Asp Ile Leu Ser His Lys Arg Xaa Ser Gly 
1               5                   10                  15      


Asn Gln Ser His Val Asp Pro Gly Pro Xaa Pro Ile Pro His Asn Ser 
            20                  25                  30          


Ser Ser Arg Phe Asp Cys Asn Ser Val Ser Xaa Ala Ala Val Leu Leu 
        35                  40                  45              


Ala Asp Ile Leu Pro Xaa Leu Val Ile Lys Leu Leu Ala Pro Leu Gly 
    50                  55                  60                  


Leu His Leu Leu Pro Tyr Ser Pro Arg Val Leu Val Ser Gly Ile Cys 
65                  70                  75                  80  


Ala Ala Gly Ser Phe Val Leu Val Ala Phe Ser His Ser Val Gly Xaa 
                85                  90                  95      


Ser Leu Cys Gly Val Val Phe Ala Ser Ile Ser Ser Gly Leu Gly Glu 
            100                 105                 110         


Val Xaa Phe Leu Ser Leu Xaa Ala Phe Tyr Pro Ser Tyr Phe Leu Leu 
        115                 120                 125             


Leu Xaa Ser Pro Glu Ala Gln Asp Pro Gly Gly Glu Glu Glu Ala Glu 
    130                 135                 140                 


Ser Ala Ala Arg Gln Pro Leu Ile Arg Xaa Glu Ala Pro Glu Ser Lys 
145                 150                 155                 160 


Pro Gly Ser Ser Ser Ser Leu Ser Leu Arg Glu Arg Trp Xaa Val Phe 
                165                 170                 175     


Lys Gly Leu Leu Trp Tyr Ile Val Pro Leu Val Val Val Tyr Phe Ala 
            180                 185                 190         


Glu Tyr Phe Ile Asn Gln Gly Leu Phe Glu Leu Leu Phe Phe Trp Asn 
        195                 200                 205             


Xaa Ser Leu Ser His Ala Gln Gln Tyr Arg Trp Tyr Gln Met Leu Tyr 
    210                 215                 220                 


Gln Ala Gly Val Phe Ala Ser Arg Ser Ser Leu Arg Cys Cys Arg Ile 
225                 230                 235                 240 


Arg Phe Xaa Trp Ala Leu Ala Leu Leu Gln Cys Leu Asn Leu Val Phe 
                245                 250                 255     


Leu Leu Ala Asp Val Trp Phe Gly Phe Leu Pro Ser Ile Tyr Leu Val 
            260                 265                 270         


Phe Leu Ile Ile Leu Tyr Glu Gly Leu Leu Gly Gly Ala Ala Tyr Val 
        275                 280                 285             


Asn Xaa Phe His Asn Ile Ala Leu Glu Xaa Ser Asp Glu His Arg Glu 
    290                 295                 300                 


Phe Ala Met Ala Ala Xaa Cys Ile Ser Asp Xaa Leu Gly Ile Ser Leu 
305                 310                 315                 320 


Ser Gly Leu Leu Ala Leu Pro Leu His Asp Phe Leu Cys Gln Leu Ser 
                325                 330                 335     


<210> 6379
<211> 285
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<400> 6379
Met Leu Ser Ala Ala His Asp Ile Leu Ser His Lys Arg Xaa Ser Gly 
1               5                   10                  15      


Asn Gln Ser His Val Asp Pro Gly Pro Xaa Pro Ile Pro His Asn Ser 
            20                  25                  30          


Ser Ser Arg Phe Asp Cys Asn Ser Val Ser Xaa Ala Pro Pro Gly Ser 
        35                  40                  45              


Arg Gln Trp Asp Leu Cys Cys Trp Lys Leu Arg Pro Gly Cys Leu Phe 
    50                  55                  60                  


Ser Phe Cys Gly Asp Gln Pro Val Cys Tyr Phe Leu Leu Leu Xaa Ser 
65                  70                  75                  80  


Pro Glu Ala Gln Asp Pro Gly Gly Glu Glu Glu Ala Glu Ser Ala Ala 
                85                  90                  95      


Arg Gln Pro Leu Ile Arg Xaa Glu Ala Pro Glu Ser Lys Pro Gly Ser 
            100                 105                 110         


Ser Ser Ser Leu Ser Leu Arg Glu Arg Trp Xaa Val Phe Lys Gly Leu 
        115                 120                 125             


Leu Trp Tyr Ile Val Pro Leu Val Val Val Tyr Phe Ala Glu Tyr Phe 
    130                 135                 140                 


Ile Asn Gln Gly Leu Phe Glu Leu Leu Phe Phe Trp Asn Xaa Ser Leu 
145                 150                 155                 160 


Ser His Ala Gln Gln Tyr Arg Trp Tyr Gln Met Leu Tyr Gln Ala Gly 
                165                 170                 175     


Val Phe Ala Ser Arg Ser Ser Leu Arg Cys Cys Arg Ile Arg Phe Xaa 
            180                 185                 190         


Trp Ala Leu Ala Leu Leu Gln Cys Leu Asn Leu Val Phe Leu Leu Ala 
        195                 200                 205             


Asp Val Trp Phe Gly Phe Leu Pro Ser Ile Tyr Leu Val Phe Leu Ile 
    210                 215                 220                 


Ile Leu Tyr Glu Gly Leu Leu Gly Gly Ala Ala Tyr Val Asn Xaa Phe 
225                 230                 235                 240 


His Asn Ile Ala Leu Glu Xaa Ser Asp Glu His Arg Glu Phe Ala Met 
                245                 250                 255     


Ala Ala Xaa Cys Ile Ser Asp Xaa Leu Gly Ile Ser Leu Ser Gly Leu 
            260                 265                 270         


Leu Ala Leu Pro Leu His Asp Phe Leu Cys Gln Leu Ser 
        275                 280                 285 


<210> 6380
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<400> 6380
Met Leu Ser Ala Ala His Asp Ile Leu Ser His Lys Arg Xaa Ser Gly 
1               5                   10                  15      


Asn Gln Ser His Val Asp Pro Gly Pro Xaa Pro Ile Pro His Asn Ser 
            20                  25                  30          


Ser Ser Arg Phe Asp Cys Asn Ser Val Ser Xaa Ala Pro Pro Gly Ser 
        35                  40                  45              


Arg Gln Trp Asp Leu Cys Cys Trp Lys Leu Arg Pro Gly Cys Leu Phe 
    50                  55                  60                  


Ser Phe Cys Gly Asp Gln Pro Val Trp Cys Gly Leu Arg 
65                  70                  75          


<210> 6381
<211> 28
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<400> 6381
Met Leu Tyr Gln Ala Gly Val Phe Ala Ser Arg Ser Ser Leu Arg Cys 
1               5                   10                  15      


Cys Arg Ile Arg Phe Xaa Trp Ala Leu Ala Leu Leu 
            20                  25              


<210> 6382
<211> 277
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<400> 6382
Gly Cys Ser Leu Met Ala Gln Glu Val Asp Xaa Ala Gln Gly Ala Glu 
1               5                   10                  15      


Met Arg Arg Gly Ala Gly Ala Ala Arg Gly Arg Ala Ser Trp Cys Trp 
            20                  25                  30          


Ala Leu Ala Leu Leu Trp Leu Ala Val Val Pro Gly Trp Ser Arg Val 
        35                  40                  45              


Ser Gly Ile Pro Ser Arg Arg His Trp Pro Val Pro Tyr Lys Arg Phe 
    50                  55                  60                  


Asp Phe Arg Pro Lys Pro Asp Pro Tyr Cys Gln Ala Lys Tyr Xaa Phe 
65                  70                  75                  80  


Cys Pro Xaa Gly Ser Pro Ile Pro Val Met Glu Gly Asp Asp Asp Ile 
                85                  90                  95      


Glu Val Phe Arg Leu Gln Ala Pro Val Trp Glu Phe Lys Tyr Gly Asp 
            100                 105                 110         


Leu Leu Gly His Leu Lys Ile Met His Asp Ala Ile Gly Phe Arg Ser 
        115                 120                 125             


Xaa Leu Xaa Gly Lys Asn Tyr Xaa Met Glu Trp Tyr Glu Leu Phe Gln 
    130                 135                 140                 


Leu Gly Asn Cys Xaa Phe Pro His Leu Arg Pro Glu Met Asp Ala Pro 
145                 150                 155                 160 


Phe Trp Cys Asn Gln Gly Ala Ala Cys Phe Phe Glu Gly Ile Asp Asp 
                165                 170                 175     


Val His Trp Lys Glu Asn Gly Xaa Leu Val Gln Val Ala Xaa Ile Ser 
            180                 185                 190         


Gly Phe His His Val Gly Gln Asp Ser Ile Glu Leu Arg Xaa Ser Ser 
        195                 200                 205             


Asp Pro Pro Ile Leu Ala Ser Gln Ser Ala Gly Ile Xaa Asp Val Ser 
    210                 215                 220                 


His Cys Xaa Arg Pro Xaa Ile Arg Ile Leu Pro Gln Arg Gly Xaa Leu 
225                 230                 235                 240 


Tyr Tyr Leu Ser Leu Ala Leu Leu Pro Gly Trp Ser Xaa Val Val Arg 
                245                 250                 255     


Pro Arg Leu Xaa Ala Xaa Ser Ala Ser Arg Ile Gln Xaa Ile Phe Leu 
            260                 265                 270         


Pro Gln Pro Pro Lys 
        275         


<210> 6383
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<400> 6383
Gly Ser Xaa Gly Cys Ser Leu Met Ala Gln Glu Val Asp Xaa Ala Gln 
1               5                   10                  15      


Gly Ala Glu Met Arg Arg Gly Ala Gly Ala Ala Arg Gly Arg Ala Ser 
            20                  25                  30          


Trp Cys Trp Ala Leu Ala Leu Leu Trp Leu Ala Val Val Pro Gly Trp 
        35                  40                  45              


Ser Arg Val Ser Gly Ile Pro Ser Arg Arg His Trp Pro Val Pro Tyr 
    50                  55                  60                  


Lys Arg Phe Asp Phe Arg Pro Lys Pro Asp Pro Tyr Cys Gln Ala Lys 
65                  70                  75                  80  


Tyr Xaa Phe Cys Pro Xaa Gly Ser Pro Ile Pro Val Met Glu Gly Asp 
                85                  90                  95      


Asp Asp Ile Glu Val Phe Arg Leu Gln Ala Pro Val Trp Glu Phe Lys 
            100                 105                 110         


Tyr Gly Asp Leu Leu Gly His Leu Lys Ile Met His Asp Ala Ile Gly 
        115                 120                 125             


Phe Arg Ser Xaa Leu Xaa Gly Lys Asn Tyr Xaa Met Glu Trp Tyr Glu 
    130                 135                 140                 


Leu Phe Gln Leu Gly Asn Cys Xaa Phe Pro His Leu Arg Pro Glu Met 
145                 150                 155                 160 


Asp Ala Pro Phe Trp Cys Asn Gln Gly Ala Ala Cys Phe Phe Glu Gly 
                165                 170                 175     


Ile Asp Asp Val His Trp Lys Glu Asn Gly Xaa Leu Val Gln Val Ala 
            180                 185                 190         


Xaa Ile Ser Asp Gly Glu Xaa Glu Ala Gln Arg Gly 
        195                 200                 


<210> 6384
<211> 271
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<400> 6384
Leu Met Ala Gln Glu Val Asp Xaa Ala Gln Gly Ala Glu Met Arg Arg 
1               5                   10                  15      


Gly Ala Gly Ala Ala Arg Gly Arg Ala Ser Trp Cys Trp Ala Leu Ala 
            20                  25                  30          


Leu Leu Trp Leu Ala Val Val Pro Gly Trp Ser Arg Val Ser Gly Ile 
        35                  40                  45              


Pro Ser Arg Arg His Trp Pro Val Pro Tyr Lys Arg Phe Asp Phe Arg 
    50                  55                  60                  


Pro Lys Pro Asp Pro Tyr Cys Gln Ala Lys Tyr Xaa Phe Cys Pro Xaa 
65                  70                  75                  80  


Gly Ser Pro Ile Pro Val Met Glu Gly Asp Asp Asp Ile Glu Val Phe 
                85                  90                  95      


Arg Leu Gln Ala Pro Val Trp Glu Phe Lys Tyr Gly Asp Leu Leu Gly 
            100                 105                 110         


His Leu Lys Ile Met His Asp Ala Ile Gly Phe Arg Ser Xaa Leu Xaa 
        115                 120                 125             


Gly Lys Asn Tyr Xaa Met Glu Trp Tyr Glu Leu Phe Gln Leu Gly Asn 
    130                 135                 140                 


Cys Xaa Phe Pro His Leu Arg Pro Glu Met Asp Ala Pro Phe Trp Cys 
145                 150                 155                 160 


Asn Gln Gly Ala Ala Cys Phe Phe Glu Gly Ile Asp Asp Val His Trp 
                165                 170                 175     


Lys Glu Asn Gly Xaa Leu Val Gln Val Ala Xaa Ile Ser Gly Phe His 
            180                 185                 190         


His Val Gly Gln Asp Ser Ile Glu Leu Arg Xaa Ser Ser Asp Pro Pro 
        195                 200                 205             


Ile Leu Ala Ser Gln Ser Ala Gly Ile Xaa Asp Val Ser His Cys Xaa 
    210                 215                 220                 


Arg Pro Xaa Ile Arg Ile Leu Pro Gln Arg Gly Xaa Leu Tyr Tyr Leu 
225                 230                 235                 240 


Leu Trp Xaa Lys Xaa Phe Leu Leu Cys Ser Leu Gln Phe Ser Trp Asp 
                245                 250                 255     


Phe Gln Asn Ile Ala Xaa Pro Tyr Phe Asn Leu Leu Pro Lys Pro 
            260                 265                 270     


<210> 6385
<211> 358
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<400> 6385
Met Ala Gln Glu Val Asp Xaa Ala Gln Gly Ala Glu Met Arg Arg Gly 
1               5                   10                  15      


Ala Gly Ala Ala Arg Gly Arg Ala Ser Trp Cys Trp Ala Leu Ala Leu 
            20                  25                  30          


Leu Trp Leu Ala Val Val Pro Gly Trp Ser Arg Val Ser Gly Ile Pro 
        35                  40                  45              


Ser Arg Arg His Trp Pro Val Pro Tyr Lys Arg Phe Asp Phe Arg Pro 
    50                  55                  60                  


Lys Pro Asp Pro Tyr Cys Gln Ala Lys Tyr Xaa Phe Cys Pro Xaa Gly 
65                  70                  75                  80  


Ser Pro Ile Pro Val Met Glu Gly Asp Asp Asp Ile Glu Val Phe Arg 
                85                  90                  95      


Leu Gln Ala Pro Val Trp Glu Phe Lys Tyr Gly Asp Leu Leu Gly His 
            100                 105                 110         


Leu Lys Ile Met His Asp Ala Ile Gly Phe Arg Ser Xaa Leu Xaa Gly 
        115                 120                 125             


Lys Asn Tyr Xaa Met Glu Trp Tyr Glu Leu Phe Gln Leu Gly Asn Cys 
    130                 135                 140                 


Xaa Phe Pro His Leu Arg Pro Glu Met Asp Ala Pro Phe Trp Cys Asn 
145                 150                 155                 160 


Gln Gly Ala Ala Cys Phe Phe Glu Gly Ile Asp Asp Val His Trp Lys 
                165                 170                 175     


Glu Asn Gly Xaa Leu Val Gln Val Ala Xaa Ile Ser Gly Asn Met Phe 
            180                 185                 190         


Asn Gln Met Ala Lys Trp Val Lys Gln Asp Asn Glu Xaa Gly Ile Tyr 
        195                 200                 205             


Tyr Glu Xaa Trp Asn Val Lys Ala Ser Pro Glu Lys Gly Ala Glu Xaa 
    210                 215                 220                 


Trp Phe Asp Ser Tyr Asp Cys Ser Lys Phe Val Leu Arg Xaa Phe Asn 
225                 230                 235                 240 


Lys Leu Ala Glu Phe Gly Ala Glu Phe Lys Asn Ile Glu Xaa Asn Tyr 
                245                 250                 255     


Xaa Arg Ile Phe Leu Tyr Ser Gly Glu Pro Xaa Tyr Leu Gly Asn Glu 
            260                 265                 270         


Xaa Ser Val Phe Gly Pro Xaa Gly Asn Lys Xaa Leu Gly Leu Ala Ile 
        275                 280                 285             


Lys Arg Phe Tyr Tyr Pro Phe Lys Pro His Leu Pro Xaa Lys Glu Phe 
    290                 295                 300                 


Leu Leu Ser Leu Leu Gln Ile Phe Asp Ala Val Ile Val His Lys Gln 
305                 310                 315                 320 


Phe Tyr Leu Phe Tyr Asn Phe Glu Tyr Trp Phe Leu Pro Met Lys Phe 
                325                 330                 335     


Pro Phe Ile Lys Ile Xaa Tyr Glu Glu Ile Pro Leu Pro Ile Arg Asn 
            340                 345                 350         


Lys Xaa Leu Ser Gly Leu 
        355             


<210> 6386
<211> 36
<212> PRT
<213> Homo sapiens

<400> 6386
Met Glu Gly Asp Asp Asp Ile Glu Val Phe Arg Leu Gln Ala Pro Val 
1               5                   10                  15      


Trp Glu Phe Lys Tyr Gly Asp Leu Leu Gly His Leu Leu Leu Tyr Leu 
            20                  25                  30          


Ala Pro Gly Arg 
        35      


<210> 6387
<211> 407
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<400> 6387
Met Arg Arg Asn Leu Arg Leu Gly Pro Ser Ser Gly Ala Asp Ala Gln 
1               5                   10                  15      


Gly Gln Gly Ala Pro Arg Pro Gly Leu Ala Ala Pro Arg Met Leu Leu 
            20                  25                  30          


Pro Pro Ala Ser Gln Ala Ser Arg Gly Ser Gly Ser Xaa Gly Cys Ser 
        35                  40                  45              


Leu Met Ala Gln Glu Val Asp Xaa Ala Gln Gly Ala Glu Met Arg Arg 
    50                  55                  60                  


Gly Ala Gly Ala Ala Arg Gly Arg Ala Ser Trp Cys Trp Ala Leu Ala 
65                  70                  75                  80  


Leu Leu Trp Leu Ala Val Val Pro Gly Trp Ser Arg Val Ser Gly Ile 
                85                  90                  95      


Pro Ser Arg Arg His Trp Pro Val Pro Tyr Lys Arg Phe Asp Phe Arg 
            100                 105                 110         


Pro Lys Pro Asp Pro Tyr Cys Gln Ala Lys Tyr Xaa Phe Cys Pro Xaa 
        115                 120                 125             


Gly Ser Pro Ile Pro Val Met Glu Gly Asp Asp Asp Ile Glu Val Phe 
    130                 135                 140                 


Arg Leu Gln Ala Pro Val Trp Glu Phe Lys Tyr Gly Asp Leu Leu Gly 
145                 150                 155                 160 


His Leu Lys Ile Met His Asp Ala Ile Gly Phe Arg Ser Xaa Leu Xaa 
                165                 170                 175     


Gly Lys Asn Tyr Xaa Met Glu Trp Tyr Glu Leu Phe Gln Leu Gly Asn 
            180                 185                 190         


Cys Xaa Phe Pro His Leu Arg Pro Glu Met Asp Ala Pro Phe Trp Cys 
        195                 200                 205             


Asn Gln Gly Ala Ala Cys Phe Phe Glu Gly Ile Asp Asp Val His Trp 
    210                 215                 220                 


Lys Glu Asn Gly Xaa Leu Val Gln Val Ala Xaa Ile Ser Gly Asn Met 
225                 230                 235                 240 


Phe Asn Gln Met Ala Lys Trp Val Lys Gln Asp Asn Glu Xaa Gly Ile 
                245                 250                 255     


Tyr Tyr Glu Xaa Trp Asn Val Lys Ala Ser Pro Glu Lys Gly Ala Glu 
            260                 265                 270         


Xaa Trp Phe Asp Ser Tyr Asp Cys Ser Lys Phe Val Leu Arg Xaa Phe 
        275                 280                 285             


Asn Lys Leu Ala Glu Phe Gly Ala Glu Phe Lys Asn Ile Glu Xaa Asn 
    290                 295                 300                 


Tyr Xaa Arg Ile Phe Leu Tyr Ser Gly Glu Pro Xaa Tyr Leu Gly Asn 
305                 310                 315                 320 


Glu Xaa Ser Val Phe Gly Pro Xaa Gly Asn Lys Xaa Leu Gly Leu Ala 
                325                 330                 335     


Ile Lys Arg Phe Tyr Tyr Pro Phe Lys Pro His Leu Pro Xaa Lys Glu 
            340                 345                 350         


Phe Leu Leu Ser Leu Leu Gln Ile Phe Asp Ala Val Ile Val His Lys 
        355                 360                 365             


Gln Phe Tyr Leu Phe Tyr Asn Phe Glu Tyr Trp Phe Leu Pro Met Lys 
    370                 375                 380                 


Phe Pro Phe Ile Lys Ile Xaa Tyr Glu Glu Ile Pro Leu Pro Ile Arg 
385                 390                 395                 400 


Asn Lys Xaa Leu Ser Gly Leu 
                405         


<210> 6388
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<400> 6388
Xaa Gly Arg Ala Ser Trp Cys Trp Ala Leu Ala Leu Leu Trp Leu Ala 
1               5                   10                  15      


Val Val Pro Gly Trp Ser Arg Val Ser Gly Ile Pro Ser Arg Arg His 
            20                  25                  30          


Trp Pro Val Pro Tyr Lys Arg Phe Asp Phe Arg Pro Lys Pro Asp Pro 
        35                  40                  45              


Tyr Cys Gln Ala Lys Tyr Xaa Phe Cys Pro Xaa Gly Ser Pro Ile Pro 
    50                  55                  60                  


Val Met Glu Gly Asp Asp Asp Ile Glu Val Phe Arg Leu Gln Ala Pro 
65                  70                  75                  80  


Val Trp Glu Phe Lys Tyr Gly Asp Leu Leu Gly His Leu Val Xaa Trp 
                85                  90                  95      


Xaa His Gly Cys Val Xaa Val Ala Phe Ile His Val Leu Ser Leu His 
            100                 105                 110         


Arg Lys Leu Cys Met Met Pro Leu Asp Ser Glu Val His 
        115                 120                 125 


<210> 6389
<211> 304
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<400> 6389
Xaa Gly Tyr Lys Arg Phe Asp Phe Arg Pro Lys Pro Asp Pro Tyr Cys 
1               5                   10                  15      


Gln Ala Lys Tyr Xaa Phe Cys Pro Xaa Gly Ser Pro Ile Pro Val Met 
            20                  25                  30          


Glu Gly Asp Asp Asp Ile Glu Val Phe Arg Leu Gln Ala Pro Val Trp 
        35                  40                  45              


Glu Phe Lys Tyr Gly Asp Leu Leu Gly His Leu Lys Ile Met His Asp 
    50                  55                  60                  


Ala Ile Gly Phe Arg Ser Xaa Leu Xaa Gly Lys Asn Tyr Xaa Met Glu 
65                  70                  75                  80  


Trp Tyr Glu Leu Phe Gln Leu Gly Asn Cys Xaa Phe Pro His Leu Arg 
                85                  90                  95      


Pro Glu Met Asp Ala Pro Phe Trp Cys Asn Gln Gly Ala Ala Cys Phe 
            100                 105                 110         


Phe Glu Gly Ile Asp Asp Val His Trp Lys Glu Asn Gly Xaa Leu Val 
        115                 120                 125             


Gln Val Ala Xaa Ile Ser Gly Asn Met Phe Asn Gln Met Ala Lys Trp 
    130                 135                 140                 


Val Lys Gln Asp Asn Glu Xaa Gly Ile Tyr Tyr Glu Xaa Trp Asn Val 
145                 150                 155                 160 


Lys Ala Ser Pro Glu Lys Gly Ala Glu Xaa Trp Phe Asp Ser Tyr Asp 
                165                 170                 175     


Cys Ser Lys Phe Val Leu Arg Xaa Phe Asn Lys Leu Ala Glu Phe Gly 
            180                 185                 190         


Ala Glu Phe Lys Asn Ile Glu Xaa Asn Tyr Xaa Arg Ile Phe Leu Tyr 
        195                 200                 205             


Ser Gly Glu Pro Xaa Tyr Leu Gly Asn Glu Xaa Ser Val Phe Gly Pro 
    210                 215                 220                 


Xaa Gly Asn Lys Xaa Leu Gly Leu Ala Ile Lys Arg Phe Tyr Tyr Pro 
225                 230                 235                 240 


Phe Lys Pro His Leu Pro Xaa Lys Glu Phe Leu Leu Ser Leu Leu Gln 
                245                 250                 255     


Ile Phe Asp Ala Val Ile Val His Lys Gln Phe Tyr Leu Phe Tyr Asn 
            260                 265                 270         


Phe Glu Tyr Trp Phe Leu Pro Met Lys Phe Pro Phe Ile Lys Ile Xaa 
        275                 280                 285             


Tyr Glu Glu Ile Pro Leu Pro Ile Arg Asn Lys Xaa Leu Ser Gly Leu 
    290                 295                 300                 


<210> 6390
<211> 216
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<400> 6390
Xaa Leu Pro Pro Ala Ser Gln Ala Ser Arg Gly Ser Gly Ser Xaa Gly 
1               5                   10                  15      


Cys Ser Leu Met Ala Gln Glu Val Asp Xaa Ala Gln Gly Ala Glu Met 
            20                  25                  30          


Arg Arg Gly Ala Gly Ala Ala Arg Gly Arg Ala Ser Trp Cys Trp Ala 
        35                  40                  45              


Leu Ala Leu Leu Trp Leu Ala Val Val Pro Gly Trp Ser Arg Val Ser 
    50                  55                  60                  


Gly Ile Pro Ser Arg Arg His Trp Pro Val Pro Tyr Lys Arg Phe Asp 
65                  70                  75                  80  


Phe Arg Pro Lys Pro Asp Pro Tyr Cys Gln Ala Lys Tyr Xaa Phe Cys 
                85                  90                  95      


Pro Xaa Gly Ser Pro Ile Pro Val Met Glu Gly Asp Asp Asp Ile Glu 
            100                 105                 110         


Val Phe Arg Leu Gln Ala Pro Val Trp Glu Phe Lys Tyr Gly Asp Leu 
        115                 120                 125             


Leu Gly His Leu Lys Ile Met His Asp Ala Ile Gly Phe Arg Ser Xaa 
    130                 135                 140                 


Leu Xaa Gly Lys Asn Tyr Xaa Met Glu Trp Tyr Glu Leu Phe Gln Leu 
145                 150                 155                 160 


Gly Asn Cys Xaa Phe Pro His Leu Arg Pro Glu Met Asp Ala Pro Phe 
                165                 170                 175     


Trp Cys Asn Gln Gly Ala Ala Cys Phe Phe Glu Gly Ile Asp Asp Val 
            180                 185                 190         


His Trp Lys Glu Asn Gly Xaa Leu Val Gln Val Ala Xaa Ile Ser Asp 
        195                 200                 205             


Gly Glu Xaa Glu Ala Gln Arg Gly 
    210                 215     


<210> 6391
<211> 249
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<400> 6391
Xaa Met Ala Gln Glu Val Asp Xaa Ala Gln Gly Ala Glu Met Arg Arg 
1               5                   10                  15      


Gly Ala Gly Ala Ala Arg Gly Arg Ala Ser Trp Cys Trp Ala Leu Ala 
            20                  25                  30          


Leu Leu Trp Leu Ala Val Val Pro Gly Trp Ser Arg Val Ser Gly Ile 
        35                  40                  45              


Pro Ser Arg Arg His Trp Pro Val Pro Tyr Lys Arg Phe Asp Phe Arg 
    50                  55                  60                  


Pro Lys Pro Asp Pro Tyr Cys Gln Ala Lys Tyr Xaa Phe Cys Pro Xaa 
65                  70                  75                  80  


Gly Ser Pro Ile Pro Val Met Glu Gly Asp Asp Asp Ile Glu Val Phe 
                85                  90                  95      


Arg Leu Gln Ala Pro Val Trp Glu Phe Lys Tyr Gly Asp Leu Leu Gly 
            100                 105                 110         


His Leu Lys Ile Met His Asp Ala Ile Gly Phe Arg Ser Xaa Leu Xaa 
        115                 120                 125             


Gly Lys Asn Tyr Xaa Met Glu Trp Tyr Glu Leu Phe Gln Leu Gly Asn 
    130                 135                 140                 


Cys Xaa Phe Pro His Leu Arg Pro Glu Met Asp Ala Pro Phe Trp Cys 
145                 150                 155                 160 


Asn Gln Gly Ala Ala Cys Phe Phe Glu Gly Ile Asp Asp Val His Trp 
                165                 170                 175     


Lys Glu Asn Gly Xaa Leu Val Gln Val Ala Xaa Ile Ser Gly Phe His 
            180                 185                 190         


His Val Gly Gln Asp Ser Ile Glu Leu Arg Xaa Ser Ser Asp Pro Pro 
        195                 200                 205             


Ile Leu Ala Ser Gln Ser Ala Gly Ile Xaa Asp Val Ser His Cys Xaa 
    210                 215                 220                 


Arg Pro Xaa Ile Arg Ile Leu Pro Gln Arg Gly Xaa Leu Tyr Tyr Leu 
225                 230                 235                 240 


Arg Trp Val Leu Leu Cys Cys Pro Gly 
                245                 


<210> 6392
<211> 205
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<400> 6392
Xaa Gln Ala Ser Arg Gly Ser Gly Ser Xaa Gly Cys Ser Leu Met Ala 
1               5                   10                  15      


Gln Glu Val Asp Xaa Ala Gln Gly Ala Glu Met Arg Arg Gly Ala Gly 
            20                  25                  30          


Ala Ala Arg Gly Arg Ala Ser Trp Cys Trp Ala Leu Ala Leu Leu Trp 
        35                  40                  45              


Leu Ala Val Val Pro Gly Trp Ser Arg Val Ser Gly Ile Pro Ser Arg 
    50                  55                  60                  


Arg His Trp Pro Val Pro Tyr Lys Arg Phe Asp Phe Arg Pro Lys Pro 
65                  70                  75                  80  


Asp Pro Tyr Cys Gln Ala Lys Tyr Xaa Phe Cys Pro Xaa Gly Ser Pro 
                85                  90                  95      


Ile Pro Val Met Glu Gly Asp Asp Asp Ile Glu Val Phe Arg Leu Gln 
            100                 105                 110         


Ala Pro Val Trp Glu Phe Lys Tyr Gly Asp Leu Leu Gly His Leu Lys 
        115                 120                 125             


Ile Met His Asp Ala Ile Gly Phe Arg Ser Xaa Leu Xaa Gly Lys Asn 
    130                 135                 140                 


Tyr Xaa Met Glu Trp Tyr Glu Leu Phe Gln Leu Gly Asn Cys Xaa Phe 
145                 150                 155                 160 


Pro His Leu Arg Pro Glu Met Asp Ala Pro Phe Trp Cys Asn Gln Gly 
                165                 170                 175     


Ala Ala Cys Phe Phe Glu Gly Ile Asp Asp Val His Trp Lys Glu Asn 
            180                 185                 190         


Gly Xaa Leu Val Gln Val Ala Xaa Ile Ser Gly Lys Leu 
        195                 200                 205 


<210> 6393
<211> 210
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<400> 6393
Xaa Ser Leu Met Ala Gln Glu Val Asp Xaa Ala Gln Gly Ala Glu Met 
1               5                   10                  15      


Arg Arg Gly Ala Gly Ala Ala Arg Gly Arg Ala Ser Trp Cys Trp Ala 
            20                  25                  30          


Leu Ala Leu Leu Trp Leu Ala Val Val Pro Gly Trp Ser Arg Val Ser 
        35                  40                  45              


Gly Ile Pro Ser Arg Arg His Trp Pro Val Pro Tyr Lys Arg Phe Asp 
    50                  55                  60                  


Phe Arg Pro Lys Pro Asp Pro Tyr Cys Gln Ala Lys Tyr Xaa Phe Cys 
65                  70                  75                  80  


Pro Xaa Gly Ser Pro Ile Pro Val Met Glu Gly Asp Asp Asp Ile Glu 
                85                  90                  95      


Val Phe Arg Leu Gln Ala Pro Val Trp Glu Phe Lys Tyr Gly Asp Leu 
            100                 105                 110         


Leu Gly His Leu Lys Ile Met His Asp Ala Ile Gly Phe Arg Ser Xaa 
        115                 120                 125             


Leu Xaa Gly Lys Asn Tyr Xaa Met Glu Trp Tyr Glu Leu Phe Gln Leu 
    130                 135                 140                 


Gly Asn Cys Xaa Phe Pro His Leu Arg Pro Glu Met Asp Ala Pro Phe 
145                 150                 155                 160 


Trp Cys Asn Gln Gly Ala Ala Cys Phe Phe Glu Gly Ile Asp Asp Val 
                165                 170                 175     


His Trp Lys Glu Asn Gly Xaa Leu Val Gln Val Ala Xaa Ile Ser Glu 
            180                 185                 190         


Ile Ser Cys Ala Leu Lys Asn Gly Ile Lys Leu Ala Glu Leu Gly Phe 
        195                 200                 205             


Leu Leu 
    210 


<210> 6394
<211> 169
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 6394
Met Asn Lys Pro Leu Leu Asp Trp Glu Arg Asn Phe Ala Ala Val Leu 
1               5                   10                  15      


Asp Gly Ala Lys Gly His Ser Asp Asp Asp Tyr Asp Asp Pro Glu Leu 
            20                  25                  30          


Arg Met Glu Glu Xaa Trp Gln Ser Ile Lys Ile Leu Pro Ala Arg Pro 
        35                  40                  45              


Ile Lys Glu Ser Glu Tyr Ala Asp Xaa His Tyr Phe Lys Val Ala Met 
    50                  55                  60                  


Asp Xaa Pro Leu Pro Leu Asp Xaa Arg Xaa Ser Ile Ser Ile Gly Gln 
65                  70                  75                  80  


Pro Xaa Trp Asn Xaa Gln Xaa Arg Leu Glu Arg Val Asp Lys Pro Ile 
                85                  90                  95      


Ser Lys Asp Val Arg Ser Gln Asn Ile Lys Gly Asp Ala Ser Val Arg 
            100                 105                 110         


Lys Asn Lys Ile Pro Leu Pro Pro Pro Arg Pro Leu Ile Xaa Leu Pro 
        115                 120                 125             


Lys Lys Tyr Gln Pro Leu Pro Pro Glu Pro Glu Ser Ser Arg Pro Pro 
    130                 135                 140                 


Leu Ser Gln Arg His Xaa Phe Pro Glu Val Gln Arg Met Pro Ser Gln 
145                 150                 155                 160 


Ile Ser Leu Arg Asp Leu Ser Glu Pro 
                165                 


<210> 6395
<211> 428
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<400> 6395
Met Asn Pro Arg Gly Asn Arg Lys Xaa Xaa Lys Glu Gly Ser Asn Asp 
1               5                   10                  15      


Leu Lys Phe Gln Asn Phe Ser Leu Pro Lys Asn Arg Ser Trp Pro Arg 
            20                  25                  30          


Ile Asn Ser Ala Xaa Gly Gln Tyr Gln Arg Met Asn Lys Pro Leu Leu 
        35                  40                  45              


Asp Trp Glu Arg Asn Phe Ala Ala Val Leu Asp Gly Ala Lys Gly His 
    50                  55                  60                  


Ser Asp Asp Asp Tyr Asp Asp Pro Glu Leu Arg Met Glu Glu Xaa Trp 
65                  70                  75                  80  


Gln Ser Ile Lys Ile Leu Pro Ala Arg Pro Ile Lys Glu Ser Glu Tyr 
                85                  90                  95      


Ala Asp Xaa His Tyr Phe Lys Val Ala Met Asp Xaa Pro Leu Pro Leu 
            100                 105                 110         


Asp Xaa Arg Xaa Ser Ile Ser Ile Gly Gln Pro Xaa Trp Asn Xaa Gln 
        115                 120                 125             


Xaa Arg Leu Glu Arg Val Asp Lys Pro Ile Ser Lys Asp Val Arg Ser 
    130                 135                 140                 


Gln Asn Ile Lys Gly Asp Ala Ser Val Arg Lys Asn Lys Ile Pro Leu 
145                 150                 155                 160 


Pro Pro Pro Arg Pro Leu Ile Xaa Leu Pro Lys Lys Tyr Gln Pro Leu 
                165                 170                 175     


Pro Pro Glu Pro Glu Ser Ser Arg Pro Pro Leu Ser Gln Arg His Xaa 
            180                 185                 190         


Phe Pro Glu Val Gln Arg Met Pro Ser Gln Ile Ser Leu Arg Asp Leu 
        195                 200                 205             


Ser Glu Val Leu Glu Ala Glu Lys Val Pro His Asn Gln Arg Lys Pro 
    210                 215                 220                 


Glu Ser Xaa His Leu Leu Glu Asn Gln Asn Xaa Gln Glu Ile Pro Leu 
225                 230                 235                 240 


Ala Ile Ser Ser Ser Ser Phe Xaa Xaa Ser Asn His Ser Val Gln Asn 
                245                 250                 255     


Arg Asp His Arg Gly Gly Met Gln Pro Cys Ser Pro Gln Arg Cys Gln 
            260                 265                 270         


Pro Pro Ala Ser Cys Ser Pro His Glu Asn Ile Leu Pro Tyr Lys Tyr 
        275                 280                 285             


Xaa Ser Trp Arg Pro Pro Phe Pro Lys Arg Ser Asp Arg Lys Asp Val 
    290                 295                 300                 


Gln His Asn Glu Trp Tyr Ile Gly Glu Tyr Ser Arg Gln Ala Val Glu 
305                 310                 315                 320 


Glu Ala Phe Met Lys Glu Asn Lys Asp Gly Ser Phe Leu Val Arg Asp 
                325                 330                 335     


Cys Ser Xaa Lys Ser Lys Glu Glu Pro Tyr Val Leu Ala Val Phe Tyr 
            340                 345                 350         


Glu Asn Lys Val Tyr Asn Val Lys Ile Arg Phe Leu Glu Arg Asn Gln 
        355                 360                 365             


Gln Phe Ala Leu Gly Xaa Gly Leu Arg Gly Asp Glu Lys Phe Asp Ser 
    370                 375                 380                 


Val Glu Asp Ile Ile Glu His Tyr Lys Asn Phe Pro Ile Ile Leu Ile 
385                 390                 395                 400 


Asp Gly Lys Asp Lys Xaa Gly Val His Arg Lys Gln Cys His Leu Xaa 
                405                 410                 415     


Gln Pro Leu Pro Leu Xaa Arg His Leu Leu Pro Leu 
            420                 425             


<210> 6396
<211> 428
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<400> 6396
Met Asn Arg Gln Gly Asn Arg Lys Xaa Xaa Lys Glu Gly Ser Asn Asp 
1               5                   10                  15      


Leu Lys Phe Gln Asn Phe Ser Leu Pro Lys Asn Arg Ser Trp Pro Arg 
            20                  25                  30          


Ile Asn Ser Ala Xaa Gly Gln Tyr Gln Arg Met Asn Lys Pro Leu Leu 
        35                  40                  45              


Asp Trp Glu Arg Asn Phe Ala Ala Val Leu Asp Gly Ala Lys Gly His 
    50                  55                  60                  


Ser Asp Asp Asp Tyr Asp Asp Pro Glu Leu Arg Met Glu Glu Xaa Trp 
65                  70                  75                  80  


Gln Ser Ile Lys Ile Leu Pro Ala Arg Pro Ile Lys Glu Ser Glu Tyr 
                85                  90                  95      


Ala Asp Xaa His Tyr Phe Lys Val Ala Met Asp Xaa Pro Leu Pro Leu 
            100                 105                 110         


Asp Xaa Arg Xaa Ser Ile Ser Ile Gly Gln Pro Xaa Trp Asn Xaa Gln 
        115                 120                 125             


Xaa Arg Leu Glu Arg Val Asp Lys Pro Ile Ser Lys Asp Val Arg Ser 
    130                 135                 140                 


Gln Asn Ile Lys Gly Asp Ala Ser Val Arg Lys Asn Lys Ile Pro Leu 
145                 150                 155                 160 


Pro Pro Pro Arg Pro Leu Ile Xaa Leu Pro Lys Lys Tyr Gln Pro Leu 
                165                 170                 175     


Pro Pro Glu Pro Glu Ser Ser Arg Pro Pro Leu Ser Gln Arg His Xaa 
            180                 185                 190         


Phe Pro Glu Val Gln Arg Met Pro Ser Gln Ile Ser Leu Arg Asp Leu 
        195                 200                 205             


Ser Glu Val Leu Glu Ala Glu Lys Val Pro His Asn Gln Arg Lys Pro 
    210                 215                 220                 


Glu Ser Xaa His Leu Leu Glu Asn Gln Asn Xaa Gln Glu Ile Pro Leu 
225                 230                 235                 240 


Ala Ile Ser Ser Ser Ser Phe Xaa Xaa Ser Asn His Ser Val Gln Asn 
                245                 250                 255     


Arg Asp His Arg Gly Gly Met Gln Pro Cys Ser Pro Gln Arg Cys Gln 
            260                 265                 270         


Pro Pro Ala Ser Cys Ser Pro His Glu Asn Ile Leu Pro Tyr Lys Tyr 
        275                 280                 285             


Xaa Ser Trp Arg Pro Pro Phe Pro Lys Arg Ser Asp Arg Lys Asp Val 
    290                 295                 300                 


Gln His Asn Glu Trp Tyr Ile Gly Glu Tyr Ser Arg Gln Ala Val Glu 
305                 310                 315                 320 


Glu Ala Phe Met Lys Glu Asn Lys Asp Gly Ser Phe Leu Val Arg Asp 
                325                 330                 335     


Cys Ser Xaa Lys Ser Lys Glu Glu Pro Tyr Val Leu Ala Val Phe Tyr 
            340                 345                 350         


Glu Asn Lys Val Tyr Asn Val Lys Ile Arg Phe Leu Glu Arg Asn Gln 
        355                 360                 365             


Gln Phe Ala Leu Gly Xaa Gly Leu Arg Gly Asp Glu Lys Phe Asp Ser 
    370                 375                 380                 


Val Glu Asp Ile Ile Glu His Tyr Lys Asn Phe Pro Ile Ile Leu Ile 
385                 390                 395                 400 


Asp Gly Lys Asp Lys Xaa Gly Val His Arg Lys Gln Cys His Leu Xaa 
                405                 410                 415     


Gln Pro Leu Pro Leu Xaa Arg His Leu Leu Pro Leu 
            420                 425             


<210> 6397
<211> 166
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<400> 6397
Met Gln Pro Cys Ser Pro Gln Arg Cys Gln Pro Pro Ala Ser Cys Ser 
1               5                   10                  15      


Pro His Glu Asn Ile Leu Pro Tyr Lys Tyr Xaa Ser Trp Arg Pro Pro 
            20                  25                  30          


Phe Pro Lys Arg Ser Asp Arg Lys Asp Val Gln His Asn Glu Trp Tyr 
        35                  40                  45              


Ile Gly Glu Tyr Ser Arg Gln Ala Val Glu Glu Ala Phe Met Lys Glu 
    50                  55                  60                  


Asn Lys Asp Gly Ser Phe Leu Val Arg Asp Cys Ser Xaa Lys Ser Lys 
65                  70                  75                  80  


Glu Glu Pro Tyr Val Leu Ala Val Phe Tyr Glu Asn Lys Val Tyr Asn 
                85                  90                  95      


Val Lys Ile Arg Phe Leu Glu Arg Asn Gln Gln Phe Ala Leu Gly Xaa 
            100                 105                 110         


Gly Leu Arg Gly Asp Glu Lys Phe Asp Ser Val Glu Asp Ile Ile Glu 
        115                 120                 125             


His Tyr Lys Asn Phe Pro Ile Ile Leu Ile Asp Gly Lys Asp Lys Xaa 
    130                 135                 140                 


Gly Val His Arg Lys Gln Cys His Leu Xaa Gln Pro Leu Pro Leu Xaa 
145                 150                 155                 160 


Arg His Leu Leu Pro Leu 
                165     


<210> 6398
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<400> 6398
Met Leu Phe Xaa Val Ser Cys Ser Lys Met Ser Ser Ile Val Asp Arg 
1               5                   10                  15      


Asp Asp Ser Ser Ile Phe Asp Gly Leu Val Glu Glu Asp Asp Lys Asp 
            20                  25                  30          


Lys Ala Lys Arg Val Ser Arg Asn Lys Ser Glu Lys Lys Arg Arg Asp 
        35                  40                  45              


Gln Phe Asn Val Leu Ile Lys Glu Leu Gly Ser Met Leu Pro Gly Asn 
    50                  55                  60                  


Ala Arg Lys Met Asp Lys Ser Xaa Val Leu Gln Lys Ser Ile Asp Phe 
65                  70                  75                  80  


Leu Arg Lys His Lys Glu Ile Xaa Ala Gln Ser Asp Ala Ser Glu Ile 
                85                  90                  95      


Arg Gln Asp Trp Lys Pro Xaa Phe Leu Ser Asn Glu Glu Phe Xaa Gln 
            100                 105                 110         


Leu Met Leu Glu Ala Leu Asp Gly Phe Phe Leu Ala Ile Met Xaa Asp 
        115                 120                 125             


Gly Ser Ile Ile Tyr Val Ser Glu Ser Val Xaa Ser Leu Leu Glu His 
    130                 135                 140                 


Leu Pro Ser Asp Leu Val Asp Gln Ser Ile Phe Asn Phe Ile Pro Glu 
145                 150                 155                 160 


Gly Glu His Ser Glu Val Tyr Lys Ile Leu Ser Xaa His Leu Leu Glu 
                165                 170                 175     


Ser Asp Ser Leu Xaa Pro 
            180         


<210> 6399
<211> 846
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (798)..(798)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<400> 6399
Met Leu Phe Xaa Val Ser Cys Ser Lys Met Ser Ser Ile Val Asp Arg 
1               5                   10                  15      


Asp Asp Ser Ser Ile Phe Asp Gly Leu Val Glu Glu Asp Asp Lys Asp 
            20                  25                  30          


Lys Ala Lys Arg Val Ser Arg Asn Lys Ser Glu Lys Lys Arg Arg Asp 
        35                  40                  45              


Gln Phe Asn Val Leu Ile Lys Glu Leu Gly Ser Met Leu Pro Gly Asn 
    50                  55                  60                  


Ala Arg Lys Met Asp Lys Ser Xaa Val Leu Gln Lys Ser Ile Asp Phe 
65                  70                  75                  80  


Leu Arg Lys His Lys Glu Ile Xaa Ala Gln Ser Asp Ala Ser Glu Ile 
                85                  90                  95      


Arg Gln Asp Trp Lys Pro Xaa Phe Leu Ser Asn Glu Glu Phe Xaa Gln 
            100                 105                 110         


Leu Met Leu Glu Ala Leu Asp Gly Phe Phe Leu Ala Ile Met Xaa Asp 
        115                 120                 125             


Gly Ser Ile Ile Tyr Val Ser Glu Ser Val Xaa Ser Leu Leu Glu His 
    130                 135                 140                 


Leu Pro Ser Asp Leu Val Asp Gln Ser Ile Phe Asn Phe Ile Pro Glu 
145                 150                 155                 160 


Gly Glu His Ser Glu Val Tyr Lys Ile Leu Ser Xaa His Leu Leu Glu 
                165                 170                 175     


Ser Asp Ser Leu Xaa Pro Glu Tyr Leu Lys Ser Lys Asn Gln Leu Glu 
            180                 185                 190         


Phe Cys Cys His Met Leu Arg Gly Xaa Ile Asp Pro Lys Glu Pro Ser 
        195                 200                 205             


Xaa Tyr Glu Tyr Val Lys Phe Ile Gly Asn Phe Lys Ser Leu Asn Ser 
    210                 215                 220                 


Val Ser Ser Ser Ala His Asn Gly Phe Glu Gly Xaa Ile Gln Arg Xaa 
225                 230                 235                 240 


His Arg Pro Ser Tyr Glu Asp Arg Val Cys Phe Val Ala Xaa Val Arg 
                245                 250                 255     


Leu Ala Xaa Pro Gln Phe Ile Lys Glu Met Cys Xaa Val Glu Glu Pro 
            260                 265                 270         


Asn Glu Glu Phe Xaa Ser Arg His Ser Leu Glu Trp Lys Phe Leu Phe 
        275                 280                 285             


Leu Asp His Arg Ala Pro Pro Ile Ile Gly Tyr Leu Pro Phe Glu Val 
    290                 295                 300                 


Leu Gly Xaa Ser Gly Tyr Asp Tyr Tyr His Val Asp Asp Leu Glu Asn 
305                 310                 315                 320 


Leu Ala Lys Cys His Glu His Leu Met Gln Tyr Gly Lys Gly Lys Ser 
                325                 330                 335     


Cys Tyr Tyr Arg Phe Leu Xaa Lys Gly Gln Gln Trp Ile Trp Leu Gln 
            340                 345                 350         


Xaa His Tyr Tyr Ile Xaa Tyr His Gln Trp Asn Ser Arg Pro Glu Phe 
        355                 360                 365             


Ile Val Cys Xaa His Xaa Val Val Ser Tyr Ala Glu Val Arg Ala Glu 
    370                 375                 380                 


Arg Arg Arg Glu Leu Gly Ile Glu Glu Ser Leu Pro Glu Xaa Ala Ala 
385                 390                 395                 400 


Asp Lys Ser Gln Asp Ser Gly Ser Asp Asn Arg Ile Asn Xaa Val Ser 
                405                 410                 415     


Leu Lys Glu Ala Leu Glu Arg Phe Asp His Ser Pro Xaa Pro Ser Ala 
            420                 425                 430         


Ser Ser Arg Ser Ser Arg Lys Ser Ser His Xaa Ala Val Ser Asp Pro 
        435                 440                 445             


Ser Ser Xaa Pro Xaa Lys Ile Pro Xaa Asp Xaa Ser Xaa Pro Pro Arg 
    450                 455                 460                 


Gln His Leu Pro Ala His Glu Lys Met Val Gln Arg Arg Ser Ser Phe 
465                 470                 475                 480 


Ser Ser Gln Ser Ile Asn Ser Gln Ser Val Gly Ser Ser Leu Xaa Gln 
                485                 490                 495     


Pro Val Met Ser Gln Ala Xaa Asn Leu Pro Ile Pro Gln Gly Met Ser 
            500                 505                 510         


Gln Phe Gln Phe Ser Ala Gln Leu Gly Ala Met Gln His Leu Lys Asp 
        515                 520                 525             


Gln Leu Glu Gln Arg Xaa Arg Met Ile Glu Ala Asn Ile His Arg Gln 
    530                 535                 540                 


Gln Glu Glu Leu Arg Lys Ile Gln Glu Gln Leu Gln Met Val His Gly 
545                 550                 555                 560 


Gln Gly Leu Gln Met Phe Leu Gln Gln Ser Asn Pro Gly Leu Asn Phe 
                565                 570                 575     


Gly Ser Val Gln Leu Ser Ser Gly Asn Ser Ser Asn Ile Gln Gln Leu 
            580                 585                 590         


Ala Pro Ile Asn Met Gln Gly Gln Val Val Pro Xaa Asn Gln Ile Gln 
        595                 600                 605             


Ser Gly Met Asn Xaa Gly His Ile Gly Xaa Xaa Gln His Met Ile Gln 
    610                 615                 620                 


Gln Gln Xaa Leu Gln Ser Xaa Ser Xaa Gln Ser Gln Gln Asn Val Leu 
625                 630                 635                 640 


Ser Gly His Ser Gln Gln Xaa Ser Leu Pro Ser Gln Xaa Gln Ser Xaa 
                645                 650                 655     


Leu Xaa Ala Pro Leu Tyr Asn Xaa Met Val Ile Ser Gln Pro Ala Ala 
            660                 665                 670         


Gly Ser Met Val Gln Ile Pro Ser Ser Met Pro Gln Asn Ser Xaa Gln 
        675                 680                 685             


Ser Ala Ala Val Xaa Xaa Phe Xaa Gln Asp Arg Gln Ile Arg Phe Ser 
    690                 695                 700                 


Gln Gly Gln Gln Leu Val Xaa Lys Leu Val Xaa Ala Pro Val Ala Cys 
705                 710                 715                 720 


Gly Ala Val Met Val Pro Ser Xaa Met Leu Met Gly Gln Val Val Xaa 
                725                 730                 735     


Ala Tyr Pro Xaa Phe Ala Xaa Gln Gln Gln Gln Ser Gln Xaa Leu Ser 
            740                 745                 750         


Val Xaa Gln Gln Gln Gln Gln Gln Ser Ser Gln Glu Gln Gln Leu Xaa 
        755                 760                 765             


Ser Val Gln Gln Pro Ser Gln Ala Gln Leu Xaa Gln Pro Pro Gln Gln 
    770                 775                 780                 


Phe Leu Gln Xaa Ser Arg Leu Leu His Gly Asn Pro Ser Xaa Gln Leu 
785                 790                 795                 800 


Ile Leu Ser Ala Ala Phe Pro Leu Gln Gln Ser Xaa Phe Pro Gln Ser 
                805                 810                 815     


His His Gln Gln His Gln Ser Gln Gln Gln Gln Gln Leu Ser Arg His 
            820                 825                 830         


Arg Xaa Asp Ser Leu Pro Asp Pro Ser Lys Val Gln Pro Gln 
        835                 840                 845     


<210> 6400
<211> 64
<212> PRT
<213> Homo sapiens

<400> 6400
Ala Gln Gln Glu Ser Glu Ile Ala Gly Ile Glu Asn Asp Glu Ala Phe 
1               5                   10                  15      


Ala Ile Leu Asp Gly Gly Ala Pro Gly Pro Gln Pro His Gly Glu Pro 
            20                  25                  30          


Pro Gly Gly Pro Asp Ala Val Asp Gly Val Met Asn Gly Glu Tyr Tyr 
        35                  40                  45              


Gln Met Pro Ile Leu Gly Ser Lys Lys Gln Ser Gly Lys Lys Arg Gln 
    50                  55                  60                  


<210> 6401
<211> 166
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 6401
Met Ala Glu Leu Asp Pro Phe Gly Ala Pro Ala Gly Ala Pro Gly Gly 
1               5                   10                  15      


Pro Ala Leu Gly Asn Gly Val Ala Gly Ala Gly Glu Glu Asp Pro Ala 
            20                  25                  30          


Ala Ala Phe Leu Ala Gln Gln Glu Ser Glu Ile Ala Gly Ile Glu Asn 
        35                  40                  45              


Asp Glu Ala Phe Ala Ile Leu Asp Gly Gly Ala Pro Gly Pro Gln Pro 
    50                  55                  60                  


His Gly Glu Pro Pro Gly Gly Pro Asp Ala Asn Ser Arg Lys Gln Glu 
65                  70                  75                  80  


Ala Glu Trp Lys Glu Lys Ala Ile Lys Glu Leu Glu Glu Trp Tyr Ala 
                85                  90                  95      


Arg Gln Asp Glu Gln Leu Gln Lys Xaa Lys Ala Asn Asn Arg Ala Ala 
            100                 105                 110         


Glu Glu Ala Phe Val Asn Asp Ile Asp Glu Ser Ser Pro Gly Xaa Glu 
        115                 120                 125             


Trp Glu Arg Val Ala Arg Leu Cys Asp Phe Asn Pro Lys Ser Ser Lys 
    130                 135                 140                 


Gln Ala Lys Asp Val Ser Arg Met Arg Ser Val Leu Ile Ser Leu Lys 
145                 150                 155                 160 


Gln Ala Pro Leu Val His 
                165     


<210> 6402
<211> 196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<400> 6402
Met Ala Glu Leu Asp Pro Phe Gly Ala Pro Ala Gly Ala Pro Gly Gly 
1               5                   10                  15      


Pro Ala Leu Gly Asn Gly Val Ala Gly Ala Gly Glu Glu Asp Pro Ala 
            20                  25                  30          


Ala Ala Phe Leu Ala Gln Gln Glu Ser Glu Ile Ala Gly Ile Glu Asn 
        35                  40                  45              


Asp Glu Ala Phe Ala Ile Leu Asp Gly Gly Ala Pro Gly Pro Gln Pro 
    50                  55                  60                  


His Gly Glu Pro Pro Gly Gly Pro Asp Ala Asn Ser Arg Lys Gln Glu 
65                  70                  75                  80  


Ala Glu Trp Lys Glu Lys Ala Ile Lys Glu Leu Glu Glu Trp Tyr Ala 
                85                  90                  95      


Arg Gln Asp Glu Gln Leu Gln Lys Xaa Lys Ala Asn Asn Arg Val Ala 
            100                 105                 110         


Asp Glu Ala Phe Tyr Lys Gln Pro Phe Ala Asp Val Ile Gly Tyr Val 
        115                 120                 125             


Xaa Asn Ile Asn His Pro Cys Tyr Ser Leu Glu Gln Ala Ala Glu Glu 
    130                 135                 140                 


Ala Phe Val Asn Asp Ile Asp Glu Ser Ser Pro Gly Xaa Glu Trp Glu 
145                 150                 155                 160 


Arg Val Ala Arg Leu Cys Asp Phe Asn Pro Lys Ser Ser Lys Gln Ala 
                165                 170                 175     


Lys Asp Val Ser Arg Met Arg Ser Val Leu Ile Ser Leu Lys Gln Ala 
            180                 185                 190         


Pro Leu Val His 
        195     


<210> 6403
<211> 218
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<400> 6403
Met Ala Glu Leu Asp Pro Phe Gly Ala Pro Ala Gly Ala Pro Gly Gly 
1               5                   10                  15      


Pro Ala Leu Gly Asn Gly Val Ala Gly Ala Gly Glu Glu Asp Pro Ala 
            20                  25                  30          


Ala Ala Phe Leu Ala Gln Gln Glu Ser Glu Ile Ala Gly Ile Glu Asn 
        35                  40                  45              


Asp Glu Ala Phe Ala Ile Leu Asp Gly Gly Ala Pro Gly Pro Gln Pro 
    50                  55                  60                  


His Gly Glu Pro Pro Gly Gly Pro Asp Ala Val Asp Gly Val Met Asn 
65                  70                  75                  80  


Gly Glu Tyr Tyr Gln Glu Ser Asn Gly Pro Xaa Asp Ser Tyr Ala Ala 
                85                  90                  95      


Ile Ser Gln Val Asp Arg Leu Gln Ser Glu Pro Glu Ser Ile Arg Lys 
            100                 105                 110         


Trp Arg Glu Glu Gln Met Glu Arg Leu Glu Ala Leu Asp Ala Asn Ser 
        115                 120                 125             


Arg Lys Gln Glu Ala Glu Trp Lys Glu Lys Ala Ile Lys Glu Leu Glu 
    130                 135                 140                 


Glu Trp Tyr Ala Arg Gln Asp Glu Gln Leu Gln Lys Xaa Lys Ala Asn 
145                 150                 155                 160 


Asn Arg Ala Ala Glu Glu Ala Phe Val Asn Asp Ile Asp Glu Ser Ser 
                165                 170                 175     


Pro Gly Xaa Glu Trp Glu Arg Val Ala Arg Leu Cys Asp Phe Asn Pro 
            180                 185                 190         


Lys Ser Ser Lys Gln Ala Lys Asp Val Ser Arg Met Arg Ser Val Leu 
        195                 200                 205             


Ile Ser Leu Lys Gln Ala Pro Leu Val His 
    210                 215             


<210> 6404
<211> 236
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<400> 6404
Met Ala Glu Leu Asp Pro Phe Gly Ala Pro Ala Gly Ala Pro Gly Gly 
1               5                   10                  15      


Pro Ala Leu Gly Asn Gly Val Ala Gly Ala Gly Glu Glu Asp Pro Ala 
            20                  25                  30          


Ala Ala Phe Leu Ala Gln Gln Glu Ser Glu Ile Ala Gly Ile Glu Asn 
        35                  40                  45              


Asp Glu Ala Phe Ala Ile Leu Asp Gly Gly Ala Pro Gly Pro Gln Pro 
    50                  55                  60                  


His Gly Glu Pro Pro Gly Gly Pro Asp Ala Val Asp Gly Val Met Asn 
65                  70                  75                  80  


Gly Glu Tyr Tyr Gln Glu Ser Asn Gly Pro Xaa Asp Ser Tyr Ala Ala 
                85                  90                  95      


Ile Ser Gln Val Asp Arg Leu Gln Ser Glu Pro Glu Ser Ile Arg Lys 
            100                 105                 110         


Trp Arg Glu Glu Gln Met Glu Arg Leu Glu Ala Leu Asp Ala Asn Ser 
        115                 120                 125             


Arg Lys Gln Glu Ala Glu Trp Lys Glu Lys Ala Ile Lys Glu Leu Glu 
    130                 135                 140                 


Glu Trp Tyr Ala Arg Gln Asp Glu Gln Leu Gln Lys Xaa Lys Ala Asn 
145                 150                 155                 160 


Asn Arg Val Ala Asp Glu Ala Phe Tyr Lys Gln Pro Phe Ala Asp Val 
                165                 170                 175     


Ile Gly Tyr Val Ala Ala Glu Glu Ala Phe Val Asn Asp Ile Asp Glu 
            180                 185                 190         


Ser Ser Pro Gly Xaa Glu Trp Glu Arg Val Ala Arg Leu Cys Asp Phe 
        195                 200                 205             


Asn Pro Lys Ser Ser Lys Gln Ala Lys Asp Val Ser Arg Met Arg Ser 
    210                 215                 220                 


Val Leu Ile Ser Leu Lys Gln Ala Pro Leu Val His 
225                 230                 235     


<210> 6405
<211> 248
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<400> 6405
Met Ala Glu Leu Asp Pro Phe Gly Ala Pro Ala Gly Ala Pro Gly Gly 
1               5                   10                  15      


Pro Ala Leu Gly Asn Gly Val Ala Gly Ala Gly Glu Glu Asp Pro Ala 
            20                  25                  30          


Ala Ala Phe Leu Ala Gln Gln Glu Ser Glu Ile Ala Gly Ile Glu Asn 
        35                  40                  45              


Asp Glu Ala Phe Ala Ile Leu Asp Gly Gly Ala Pro Gly Pro Gln Pro 
    50                  55                  60                  


His Gly Glu Pro Pro Gly Gly Pro Asp Ala Val Asp Gly Val Met Asn 
65                  70                  75                  80  


Gly Glu Tyr Tyr Gln Glu Ser Asn Gly Pro Xaa Asp Ser Tyr Ala Ala 
                85                  90                  95      


Ile Ser Gln Val Asp Arg Leu Gln Ser Glu Pro Glu Ser Ile Arg Lys 
            100                 105                 110         


Trp Arg Glu Glu Gln Met Glu Arg Leu Glu Ala Leu Asp Ala Asn Ser 
        115                 120                 125             


Arg Lys Gln Glu Ala Glu Trp Lys Glu Lys Ala Ile Lys Glu Leu Glu 
    130                 135                 140                 


Glu Trp Tyr Ala Arg Gln Asp Glu Gln Leu Gln Lys Xaa Lys Ala Asn 
145                 150                 155                 160 


Asn Arg Val Ala Asp Glu Ala Phe Tyr Lys Gln Pro Phe Ala Asp Val 
                165                 170                 175     


Ile Gly Tyr Val Xaa Asn Ile Asn His Pro Cys Tyr Ser Leu Glu Gln 
            180                 185                 190         


Ala Ala Glu Glu Ala Phe Val Asn Asp Ile Asp Glu Ser Ser Pro Gly 
        195                 200                 205             


Xaa Glu Trp Glu Arg Val Ala Arg Leu Cys Asp Phe Asn Pro Lys Ser 
    210                 215                 220                 


Ser Lys Gln Ala Lys Asp Val Ser Arg Met Arg Ser Val Leu Ile Ser 
225                 230                 235                 240 


Leu Lys Gln Ala Pro Leu Val His 
                245             


<210> 6406
<211> 260
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<400> 6406
Met Ala Glu Leu Asp Pro Phe Gly Ala Pro Ala Gly Ala Pro Gly Gly 
1               5                   10                  15      


Pro Ala Leu Gly Asn Gly Val Ala Gly Ala Gly Glu Glu Asp Pro Ala 
            20                  25                  30          


Ala Ala Phe Leu Ala Gln Gln Glu Ser Glu Ile Ala Gly Ile Glu Asn 
        35                  40                  45              


Asp Glu Ala Phe Ala Ile Leu Asp Gly Gly Ala Pro Gly Pro Gln Pro 
    50                  55                  60                  


His Gly Glu Pro Pro Gly Gly Pro Asp Ala Val Asp Gly Val Met Asn 
65                  70                  75                  80  


Gly Glu Tyr Tyr Gln Glu Ser Asn Gly Pro Xaa Asp Ser Tyr Ala Ala 
                85                  90                  95      


Ile Ser Gln Val Asp Arg Leu Gln Ser Glu Pro Glu Ser Ile Arg Lys 
            100                 105                 110         


Trp Arg Glu Glu Gln Met Glu Arg Leu Glu Ala Leu Asp Ala Asn Ser 
        115                 120                 125             


Arg Lys Gln Glu Ala Glu Trp Lys Glu Lys Ala Ile Lys Glu Leu Glu 
    130                 135                 140                 


Glu Trp Tyr Ala Arg Gln Asp Glu Gln Leu Gln Lys Xaa Lys Ala Asn 
145                 150                 155                 160 


Asn Arg Val Ser Leu Leu Pro Arg Leu Glu Cys Asn Gly Val Ile Ser 
                165                 170                 175     


Ala His Cys Asn Leu Cys Leu Pro Gly Ser Ser Asn Ser Pro Ala Ser 
            180                 185                 190         


Ala Ser Arg Gly Ala Gly Ile Xaa Asp Met Cys His Arg Ala Arg Leu 
        195                 200                 205             


Ile Phe Val Phe Leu Val Glu Met Gly Phe His His Val Gly Gln Ala 
    210                 215                 220                 


Gly Leu Lys Ile Leu Xaa Ser Asn Asp Leu Pro Ala Ser Ala Arg Ala 
225                 230                 235                 240 


Arg Ile Xaa Gly Arg Trp Lys Gly Val Lys Asp Val Ala Met Tyr Val 
                245                 250                 255     


Pro Ser Leu Pro 
            260 


<210> 6407
<211> 230
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<400> 6407
Met Ala Glu Leu Asp Pro Phe Gly Ala Pro Ala Gly Ala Pro Gly Gly 
1               5                   10                  15      


Pro Ala Leu Gly Asn Gly Val Ala Gly Ala Gly Glu Glu Asp Pro Ala 
            20                  25                  30          


Ala Ala Phe Leu Ala Gln Gln Glu Ser Glu Ile Ala Gly Ile Glu Asn 
        35                  40                  45              


Asp Glu Ala Phe Ala Ile Leu Asp Gly Gly Ala Pro Gly Pro Gln Pro 
    50                  55                  60                  


His Gly Glu Pro Pro Gly Gly Pro Asp Ala Val Asp Gly Val Met Asn 
65                  70                  75                  80  


Gly Glu Tyr Tyr Gln Glu Ser Asn Gly Pro Xaa Asp Ser Tyr Ala Ala 
                85                  90                  95      


Ile Ser Gln Val Asp Arg Leu Gln Ser Glu Pro Glu Ser Ile Arg Lys 
            100                 105                 110         


Trp Arg Glu Glu Gln Met Glu Arg Leu Glu Ala Leu Asp Ala Asn Ser 
        115                 120                 125             


Arg Lys Gln Glu Ala Glu Trp Lys Glu Lys Ala Ile Lys Glu Leu Glu 
    130                 135                 140                 


Glu Trp Tyr Ala Arg Gln Asp Glu Gln Leu Gln Lys Xaa Lys Ala Asn 
145                 150                 155                 160 


Asn Ser Xaa Asn Ile Asn His Pro Cys Tyr Ser Leu Glu Gln Ala Ala 
                165                 170                 175     


Glu Glu Ala Phe Val Asn Asp Ile Asp Glu Ser Ser Pro Gly Xaa Glu 
            180                 185                 190         


Trp Glu Arg Val Ala Arg Leu Cys Asp Phe Asn Pro Lys Ser Ser Lys 
        195                 200                 205             


Gln Ala Lys Asp Val Ser Arg Met Arg Ser Val Leu Ile Ser Leu Lys 
    210                 215                 220                 


Gln Ala Pro Leu Val His 
225                 230 


<210> 6408
<211> 1639
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1252)..(1252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1377)..(1377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1383)..(1383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1396)..(1396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1433)..(1433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1482)..(1482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1572)..(1572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1585)..(1585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1608)..(1608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1627)..(1627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1629)..(1629)
<223> Selenocysteine

<400> 6408
Met Ala Gln Ile Leu Pro Ile Arg Phe Gln Glu His Leu Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Xaa Leu Xaa Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Val Ile Ile Asp Met Asn Asp Pro Ser Asn Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Asp Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Xaa Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Xaa Met Xaa Asp Asp Val Xaa Phe Trp Lys 
            100                 105                 110         


Trp Ile Ser Leu Asn Xaa Val Ala Leu Val Xaa Asp Asn Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Glu Ser Gln Pro Val Lys Met Phe Asp Arg 
    130                 135                 140                 


His Ser Ser Leu Ala Gly Cys Gln Ile Ile Asn Tyr Arg Xaa Asp Ala 
145                 150                 155                 160 


Lys Gln Lys Trp Leu Leu Leu Xaa Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ser Phe Ala Gln Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Glu Glu Ser Xaa Leu Phe Cys Phe Ala Val Arg Gly Gln Ala 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Xaa Pro Pro Xaa Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Pro Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Ser Glu Lys His Asp Val 
            260                 265                 270         


Val Phe Leu Ile Xaa Lys Tyr Gly Tyr Ile His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Xaa Gly Xaa Cys Ile Tyr Met Asn Arg Ile Ser Gly Glu Xaa Ile Phe 
    290                 295                 300                 


Val Xaa Ala Pro His Glu Ala Xaa Ala Gly Ile Ile Gly Val Asn Arg 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Glu Asn Ile Ile Pro 
                325                 330                 335     


Tyr Ile Xaa Asn Val Leu Gln Asn Pro Asp Leu Ala Leu Arg Met Ala 
            340                 345                 350         


Val Arg Asn Asn Leu Ala Gly Ala Glu Glu Leu Phe Ala Arg Lys Phe 
        355                 360                 365             


Asn Ala Leu Phe Ala Gln Gly Asn Tyr Ser Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Asn Ala Pro Lys Gly Ile Leu Arg Xaa Pro Asp Xaa Ile Arg Arg 
385                 390                 395                 400 


Phe Gln Ser Val Pro Ala Gln Pro Gly Gln Xaa Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Tyr Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys Arg Pro Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Ser Val Asp Pro Xaa Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Asn Lys Val Ile Gln Cys Phe Ala Glu Xaa Gly 
                485                 490                 495     


Gln Val Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Xaa Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Asn Val Met Arg Ile Ser Pro Asp Gln 
        515                 520                 525             


Gly Gln Gln Phe Ala Gln Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asp Ile Xaa Gln Ile Val Asp Val Phe Met Glu Tyr Asn Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Xaa Ala Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ser 
                565                 570                 575     


Glu Gly Pro Leu Gln Xaa Arg Leu Leu Glu Met Asn Leu Met His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Gln Met Phe Xaa His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Arg Ala Leu Glu His Phe Xaa Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Xaa His Leu Leu Asn Pro Glu Trp Leu Val Asn Tyr Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Leu Glu Cys Leu Arg Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Ile Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Glu Gln Leu Ser Xaa Gln Ser Leu Ile Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Phe Glu Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Phe Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Xaa Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Asn 
            740                 745                 750         


Cys Tyr Asp Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Xaa Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Asp Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Lys Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Leu Pro Val Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Asp Val Ile Lys Asn Leu 
            820                 825                 830         


Ile Leu Val Val Arg Gly Gln Phe Ser Xaa Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ala 
    850                 855                 860                 


Arg Ile His Glu Gly Cys Glu Glu Pro Ala Xaa His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Asn Pro Glu Arg Phe Leu Arg Glu 
                885                 890                 895     


Asn Pro Tyr Tyr Asp Ser Arg Val Val Gly Lys Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Asn Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Leu Ser 
    930                 935                 940                 


Arg Tyr Leu Val Arg Arg Lys Asp Pro Glu Leu Trp Gly Ser Val Leu 
945                 950                 955                 960 


Leu Glu Ser Asn Pro Tyr Arg Arg Pro Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Xaa Ala Leu Ser Glu Xaa Gln Asp Pro Glu Glu Val Ser Val Xaa Val 
            980                 985                 990         


Lys Ala Phe Met Xaa Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Xaa Ala Ile Lys Ala  Asp Arg Xaa 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Asn  Arg Leu Asp Asn Tyr  Asp Ala Pro 
    1040                 1045                 1050             


Asp Ile  Ala Asn Ile Ala Ile  Ser Asn Glu Leu Phe  Glu Glu Ala 
    1055                 1060                 1065             


Phe Ala  Ile Phe Arg Lys Phe  Asp Val Asn Xaa Ser  Ala Val Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Lys 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Gly Met  Val Lys Glu Ala Ile  Asp Ser Tyr 
    1115                 1120                 1125             


Ile Lys  Ala Asp Asp Pro Ser  Ser Tyr Met Glu Val  Val Gln Ala 
    1130                 1135                 1140             


Ala Asn  Xaa Ser Gly Asn Trp  Glu Glu Leu Val Lys  Tyr Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Ala Arg  Glu Ser Tyr Val Glu  Xaa Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Xaa  Asn Arg Leu Ala Glu  Leu Glu Glu 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Asp Glu Lys Met  Tyr Asp Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Asn Asn  Val Ser Asn Phe Gly  Arg Leu Ala Ser Xaa  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Glu Tyr Gln Ala Ala  Val Asp Gly Ala Arg  Lys Ala Asn 
    1235                 1240                 1245             


Ser Xaa  Arg Xaa Trp Lys Glu  Val Cys Phe Ala Cys  Val Asp Gly 
    1250                 1255                 1260             


Lys Glu  Phe Arg Leu Ala Gln  Met Cys Gly Leu His  Ile Val Val 
    1265                 1270                 1275             


His Ala  Asp Glu Leu Glu Glu  Leu Ile Asn Tyr Tyr  Gln Asp Arg 
    1280                 1285                 1290             


Gly Tyr  Phe Glu Glu Leu Ile  Xaa Met Leu Glu Ala  Ala Leu Gly 
    1295                 1300                 1305             


Leu Glu  Arg Ala His Met Gly  Met Phe Xaa Glu Leu  Ala Ile Leu 
    1310                 1315                 1320             


Tyr Ser  Lys Phe Lys Pro Gln  Lys Met Arg Glu His  Leu Glu Leu 
    1325                 1330                 1335             


Phe Trp  Ser Arg Val Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu 
    1340                 1345                 1350             


Gln Ala  His Leu Trp Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr 
    1355                 1360                 1365             


Glu Glu  Tyr Asp Asn Ala Ile  Ile Xaa Met Met Asn  His Pro Xaa 
    1370                 1375                 1380             


Asp Ala  Trp Lys Glu Gly Gln  Phe Lys Asp Ile Ile  Xaa Lys Val 
    1385                 1390                 1395             


Ala Asn  Val Glu Leu Tyr Tyr  Arg Ala Ile Gln Phe  Tyr Leu Glu 
    1400                 1405                 1410             


Phe Lys  Pro Leu Leu Leu Asn  Asp Leu Leu Met Val  Leu Ser Pro 
    1415                 1420                 1425             


Arg Leu  Asp His Xaa Arg Ala  Val Asn Tyr Phe Ser  Lys Val Lys 
    1430                 1435                 1440             


Gln Leu  Pro Leu Val Lys Pro  Tyr Leu Arg Ser Val  Gln Asn His 
    1445                 1450                 1455             


Asn Asn  Lys Ser Val Asn Glu  Ser Leu Asn Asn Leu  Phe Ile Xaa 
    1460                 1465                 1470             


Glu Glu  Asp Tyr Gln Ala Leu  Arg Xaa Ser Ile Asp  Ala Tyr Asp 
    1475                 1480                 1485             


Asn Phe  Asp Asn Ile Ser Leu  Ala Gln Arg Leu Glu  Lys His Glu 
    1490                 1495                 1500             


Leu Ile  Glu Phe Arg Arg Ile  Ala Ala Tyr Leu Phe  Lys Gly Asn 
    1505                 1510                 1515             


Asn Arg  Trp Lys Gln Ser Val  Glu Leu Cys Lys Lys  Asp Ser Leu 
    1520                 1525                 1530             


Tyr Lys  Asp Ala Met Gln Tyr  Ala Ser Glu Ser Lys  Asp Xaa Glu 
    1535                 1540                 1545             


Leu Ala  Glu Glu Leu Leu Gln  Trp Phe Leu Gln Glu  Glu Lys Arg 
    1550                 1555                 1560             


Glu Cys  Phe Gly Ala Cys Leu  Phe Xaa Cys Tyr Asp  Leu Leu Arg 
    1565                 1570                 1575             


Pro Asp  Val Val Leu Glu Xaa  Ala Trp Arg His Asn  Ile Met Asp 
    1580                 1585                 1590             


Phe Ala  Met Pro Tyr Phe Ile  Gln Val Met Lys Glu  Tyr Leu Xaa 
    1595                 1600                 1605             


Lys Val  Asp Lys Leu Asp Ala  Ser Glu Ser Leu Arg  Lys Glu Glu 
    1610                 1615                 1620             


Glu Gln  Ala Xaa Glu Xaa Gln  Pro Ile Val Tyr Gly  Asn Leu Ser 
    1625                 1630                 1635             


Leu 
    


<210> 6409
<211> 1675
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1079)..(1079)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1252)..(1252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1377)..(1377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1383)..(1383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1396)..(1396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1433)..(1433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1473)..(1473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1482)..(1482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1572)..(1572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1585)..(1585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1608)..(1608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1627)..(1627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1629)..(1629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1642)..(1642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1660)..(1660)
<223> Selenocysteine

<400> 6409
Met Ala Gln Ile Leu Pro Ile Arg Phe Gln Glu His Leu Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Xaa Leu Xaa Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Val Ile Ile Asp Met Asn Asp Pro Ser Asn Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Asp Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Xaa Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Xaa Met Xaa Asp Asp Val Xaa Phe Trp Lys 
            100                 105                 110         


Trp Ile Ser Leu Asn Xaa Val Ala Leu Val Xaa Asp Asn Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Glu Ser Gln Pro Val Lys Met Phe Asp Arg 
    130                 135                 140                 


His Ser Ser Leu Ala Gly Cys Gln Ile Ile Asn Tyr Arg Xaa Asp Ala 
145                 150                 155                 160 


Lys Gln Lys Trp Leu Leu Leu Xaa Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ser Phe Ala Gln Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Glu Glu Ser Xaa Leu Phe Cys Phe Ala Val Arg Gly Gln Ala 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Xaa Pro Pro Xaa Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Pro Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Ser Glu Lys His Asp Val 
            260                 265                 270         


Val Phe Leu Ile Xaa Lys Tyr Gly Tyr Ile His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Xaa Gly Xaa Cys Ile Tyr Met Asn Arg Ile Ser Gly Glu Xaa Ile Phe 
    290                 295                 300                 


Val Xaa Ala Pro His Glu Ala Xaa Ala Gly Ile Ile Gly Val Asn Arg 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Glu Asn Ile Ile Pro 
                325                 330                 335     


Tyr Ile Xaa Asn Val Leu Gln Asn Pro Asp Leu Ala Leu Arg Met Ala 
            340                 345                 350         


Val Arg Asn Asn Leu Ala Gly Ala Glu Glu Leu Phe Ala Arg Lys Phe 
        355                 360                 365             


Asn Ala Leu Phe Ala Gln Gly Asn Tyr Ser Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Asn Ala Pro Lys Gly Ile Leu Arg Xaa Pro Asp Xaa Ile Arg Arg 
385                 390                 395                 400 


Phe Gln Ser Val Pro Ala Gln Pro Gly Gln Xaa Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Tyr Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys Arg Pro Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Ser Val Asp Pro Xaa Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Asn Lys Val Ile Gln Cys Phe Ala Glu Xaa Gly 
                485                 490                 495     


Gln Val Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Xaa Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Asn Val Met Arg Ile Ser Pro Asp Gln 
        515                 520                 525             


Gly Gln Gln Phe Ala Gln Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asp Ile Xaa Gln Ile Val Asp Val Phe Met Glu Tyr Asn Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Xaa Ala Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ser 
                565                 570                 575     


Glu Gly Pro Leu Gln Xaa Arg Leu Leu Glu Met Asn Leu Met His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Gln Met Phe Xaa His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Arg Ala Leu Glu His Phe Xaa Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Xaa His Leu Leu Asn Pro Glu Trp Leu Val Asn Tyr Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Leu Glu Cys Leu Arg Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Ile Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Glu Gln Leu Ser Xaa Gln Ser Leu Ile Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Phe Glu Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Phe Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Xaa Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Asn 
            740                 745                 750         


Cys Tyr Asp Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Xaa Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Asp Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Lys Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Leu Pro Val Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Asp Val Ile Lys Asn Leu 
            820                 825                 830         


Ile Leu Val Val Arg Gly Gln Phe Ser Xaa Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ala 
    850                 855                 860                 


Arg Ile His Glu Gly Cys Glu Glu Pro Ala Xaa His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Asn Pro Glu Arg Phe Leu Arg Glu 
                885                 890                 895     


Asn Pro Tyr Tyr Asp Ser Arg Val Val Gly Lys Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Asn Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Leu Ser 
    930                 935                 940                 


Arg Tyr Leu Val Arg Arg Lys Asp Pro Glu Leu Trp Gly Ser Val Leu 
945                 950                 955                 960 


Leu Glu Ser Asn Pro Tyr Arg Arg Pro Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Xaa Ala Leu Ser Glu Xaa Gln Asp Pro Glu Glu Val Ser Val Xaa Val 
            980                 985                 990         


Lys Ala Phe Met Xaa Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Xaa Ala Ile Lys Ala  Asp Arg Xaa 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Asn  Arg Leu Asp Asn Tyr  Asp Ala Pro 
    1040                 1045                 1050             


Asp Ile  Ala Asn Ile Ala Ile  Ser Asn Glu Leu Phe  Glu Glu Ala 
    1055                 1060                 1065             


Phe Ala  Ile Phe Arg Lys Phe  Asp Val Asn Xaa Ser  Ala Val Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Lys 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Gly Met  Val Lys Glu Ala Ile  Asp Ser Tyr 
    1115                 1120                 1125             


Ile Lys  Ala Asp Asp Pro Ser  Ser Tyr Met Glu Val  Val Gln Ala 
    1130                 1135                 1140             


Ala Asn  Xaa Ser Gly Asn Trp  Glu Glu Leu Val Lys  Tyr Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Ala Arg  Glu Ser Tyr Val Glu  Xaa Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Xaa  Asn Arg Leu Ala Glu  Leu Glu Glu 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Asp Glu Lys Met  Tyr Asp Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Asn Asn  Val Ser Asn Phe Gly  Arg Leu Ala Ser Xaa  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Glu Tyr Gln Ala Ala  Val Asp Gly Ala Arg  Lys Ala Asn 
    1235                 1240                 1245             


Ser Xaa  Arg Xaa Trp Lys Glu  Val Cys Phe Ala Cys  Val Asp Gly 
    1250                 1255                 1260             


Lys Glu  Phe Arg Leu Ala Gln  Met Cys Gly Leu His  Ile Val Val 
    1265                 1270                 1275             


His Ala  Asp Glu Leu Glu Glu  Leu Ile Asn Tyr Tyr  Gln Asp Arg 
    1280                 1285                 1290             


Gly Tyr  Phe Glu Glu Leu Ile  Xaa Met Leu Glu Ala  Ala Leu Gly 
    1295                 1300                 1305             


Leu Glu  Arg Ala His Met Gly  Met Phe Xaa Glu Leu  Ala Ile Leu 
    1310                 1315                 1320             


Tyr Ser  Lys Phe Lys Pro Gln  Lys Met Arg Glu His  Leu Glu Leu 
    1325                 1330                 1335             


Phe Trp  Ser Arg Val Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu 
    1340                 1345                 1350             


Gln Ala  His Leu Trp Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr 
    1355                 1360                 1365             


Glu Glu  Tyr Asp Asn Ala Ile  Ile Xaa Met Met Asn  His Pro Xaa 
    1370                 1375                 1380             


Asp Ala  Trp Lys Glu Gly Gln  Phe Lys Asp Ile Ile  Xaa Lys Val 
    1385                 1390                 1395             


Ala Asn  Val Glu Leu Tyr Tyr  Arg Ala Ile Gln Phe  Tyr Leu Glu 
    1400                 1405                 1410             


Phe Lys  Pro Leu Leu Leu Asn  Asp Leu Leu Met Val  Leu Ser Pro 
    1415                 1420                 1425             


Arg Leu  Asp His Xaa Arg Ala  Val Asn Tyr Phe Ser  Lys Val Lys 
    1430                 1435                 1440             


Gln Leu  Pro Leu Val Lys Pro  Tyr Leu Arg Ser Val  Gln Asn His 
    1445                 1450                 1455             


Asn Asn  Lys Ser Val Asn Glu  Ser Leu Asn Asn Leu  Phe Ile Xaa 
    1460                 1465                 1470             


Glu Glu  Asp Tyr Gln Ala Leu  Arg Xaa Ser Ile Asp  Ala Tyr Asp 
    1475                 1480                 1485             


Asn Phe  Asp Asn Ile Ser Leu  Ala Gln Arg Leu Glu  Lys His Glu 
    1490                 1495                 1500             


Leu Ile  Glu Phe Arg Arg Ile  Ala Ala Tyr Leu Phe  Lys Gly Asn 
    1505                 1510                 1515             


Asn Arg  Trp Lys Gln Ser Val  Glu Leu Cys Lys Lys  Asp Ser Leu 
    1520                 1525                 1530             


Tyr Lys  Asp Ala Met Gln Tyr  Ala Ser Glu Ser Lys  Asp Xaa Glu 
    1535                 1540                 1545             


Leu Ala  Glu Glu Leu Leu Gln  Trp Phe Leu Gln Glu  Glu Lys Arg 
    1550                 1555                 1560             


Glu Cys  Phe Gly Ala Cys Leu  Phe Xaa Cys Tyr Asp  Leu Leu Arg 
    1565                 1570                 1575             


Pro Asp  Val Val Leu Glu Xaa  Ala Trp Arg His Asn  Ile Met Asp 
    1580                 1585                 1590             


Phe Ala  Met Pro Tyr Phe Ile  Gln Val Met Lys Glu  Tyr Leu Xaa 
    1595                 1600                 1605             


Lys Val  Asp Lys Leu Asp Ala  Ser Glu Ser Leu Arg  Lys Glu Glu 
    1610                 1615                 1620             


Glu Gln  Ala Xaa Glu Xaa Gln  Pro Ile Val Tyr Gly  Gln Pro Gln 
    1625                 1630                 1635             


Leu Met  Leu Xaa Ala Gly Pro  Ser Val Ala Val Pro  Pro Gln Ala 
    1640                 1645                 1650             


Pro Phe  Gly Tyr Gly Tyr Xaa  Ala Pro Pro Tyr Gly  Gln Pro Gln 
    1655                 1660                 1665             


Pro Gly  Phe Gly Tyr Ser Met  
    1670                 1675 


<210> 6410
<211> 612
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<400> 6410
Met Ala Gln Ile Leu Pro Ile Arg Phe Gln Glu His Leu Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Xaa Leu Xaa Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Val Ile Ile Asp Met Asn Asp Pro Ser Asn Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Asp Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Xaa Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala Arg Glu Ser Tyr Val Glu Xaa Glu Leu Ile Phe 
            100                 105                 110         


Ala Leu Ala Lys Xaa Asn Arg Leu Ala Glu Leu Glu Glu Phe Ile Asn 
        115                 120                 125             


Gly Pro Asn Asn Ala His Ile Gln Gln Val Gly Asp Arg Cys Tyr Asp 
    130                 135                 140                 


Glu Lys Met Tyr Asp Ala Ala Lys Leu Leu Tyr Asn Asn Val Ser Asn 
145                 150                 155                 160 


Phe Gly Arg Leu Ala Ser Xaa Leu Val His Leu Gly Glu Tyr Gln Ala 
                165                 170                 175     


Ala Val Asp Gly Ala Arg Lys Ala Asn Ser Xaa Arg Xaa Trp Lys Glu 
            180                 185                 190         


Val Cys Phe Ala Cys Val Asp Gly Lys Glu Phe Arg Leu Ala Gln Met 
        195                 200                 205             


Cys Gly Leu His Ile Val Val His Ala Asp Glu Leu Glu Glu Leu Ile 
    210                 215                 220                 


Asn Tyr Tyr Gln Asp Arg Gly Tyr Phe Glu Glu Leu Ile Xaa Met Leu 
225                 230                 235                 240 


Glu Ala Ala Leu Gly Leu Glu Arg Ala His Met Gly Met Phe Xaa Glu 
                245                 250                 255     


Leu Ala Ile Leu Tyr Ser Lys Phe Lys Pro Gln Lys Met Arg Glu His 
            260                 265                 270         


Leu Glu Leu Phe Trp Ser Arg Val Asn Ile Pro Lys Val Leu Arg Ala 
        275                 280                 285             


Ala Glu Gln Ala His Leu Trp Ala Glu Leu Val Phe Leu Tyr Asp Lys 
    290                 295                 300                 


Tyr Glu Glu Tyr Asp Asn Ala Ile Ile Xaa Met Met Asn His Pro Xaa 
305                 310                 315                 320 


Asp Ala Trp Lys Glu Gly Gln Phe Lys Asp Ile Ile Xaa Lys Val Ala 
                325                 330                 335     


Asn Val Glu Leu Tyr Tyr Arg Ala Ile Gln Phe Tyr Leu Glu Phe Lys 
            340                 345                 350         


Pro Leu Leu Leu Asn Asp Leu Leu Met Val Leu Ser Pro Arg Leu Asp 
        355                 360                 365             


His Xaa Arg Ala Val Asn Tyr Phe Ser Lys Val Lys Gln Leu Pro Leu 
    370                 375                 380                 


Val Lys Pro Tyr Leu Arg Ser Val Gln Asn His Asn Asn Lys Ser Val 
385                 390                 395                 400 


Asn Glu Ser Leu Asn Asn Leu Phe Ile Xaa Glu Glu Asp Tyr Gln Ala 
                405                 410                 415     


Leu Arg Xaa Ser Ile Asp Ala Tyr Asp Asn Phe Asp Asn Ile Ser Leu 
            420                 425                 430         


Ala Gln Arg Leu Glu Lys His Glu Leu Ile Glu Phe Arg Arg Ile Ala 
        435                 440                 445             


Ala Tyr Leu Phe Lys Gly Asn Asn Arg Trp Lys Gln Ser Val Glu Leu 
    450                 455                 460                 


Cys Lys Lys Asp Ser Leu Tyr Lys Asp Ala Met Gln Tyr Ala Ser Glu 
465                 470                 475                 480 


Ser Lys Asp Xaa Glu Leu Ala Glu Glu Leu Leu Gln Trp Phe Leu Gln 
                485                 490                 495     


Glu Glu Lys Arg Glu Cys Phe Gly Ala Cys Leu Phe Xaa Cys Tyr Asp 
            500                 505                 510         


Leu Leu Arg Pro Asp Val Val Leu Glu Xaa Ala Trp Arg His Asn Ile 
        515                 520                 525             


Met Asp Phe Ala Met Pro Tyr Phe Ile Gln Val Met Lys Glu Tyr Leu 
    530                 535                 540                 


Xaa Lys Val Asp Lys Leu Asp Ala Ser Glu Ser Leu Arg Lys Glu Glu 
545                 550                 555                 560 


Glu Gln Ala Xaa Glu Xaa Gln Pro Ile Val Tyr Gly Gln Pro Gln Leu 
                565                 570                 575     


Met Leu Xaa Ala Gly Pro Ser Val Ala Val Pro Pro Gln Ala Pro Phe 
            580                 585                 590         


Gly Tyr Gly Tyr Xaa Ala Pro Pro Tyr Gly Gln Pro Gln Pro Gly Phe 
        595                 600                 605             


Gly Tyr Ser Met 
    610         


<210> 6411
<211> 97
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<400> 6411
Met Ala Gln Ile Leu Pro Ile Arg Phe Gln Glu His Leu Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Xaa Leu Xaa Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Val Ile Ile Asp Met Asn Asp Pro Ser Asn Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Asp Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Lys Ser Cys Gly Gly Ser Tyr Ala Ala Ile Phe Cys 
                85                  90                  95      


Arg 
    


<210> 6412
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<400> 6412
Met Ala Gln Ile Leu Pro Ile Arg Phe Gln Glu His Leu Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Xaa Leu Xaa Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Val Ile Ile Asp Met Asn Asp Pro Ser Asn Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Asp Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Gly Ile Lys Glu Ser Gly Lys Xaa Leu Gln Ile Phe Asn 
                85                  90                  95      


Ile Glu Met Lys Ser Lys Met Lys Ala His Xaa Met Xaa Asp Asp Val 
            100                 105                 110         


Xaa Phe Trp Lys Trp Ile Ser Leu Asn Xaa 
        115                 120         


<210> 6413
<211> 1679
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1083)..(1083)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1184)..(1184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1234)..(1234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1256)..(1256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1322)..(1322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1387)..(1387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1400)..(1400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1437)..(1437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1477)..(1477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1486)..(1486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1551)..(1551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1576)..(1576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1589)..(1589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1612)..(1612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1631)..(1631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1633)..(1633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1664)..(1664)
<223> Selenocysteine

<400> 6413
Met Ala Gln Ile Leu Pro Ile Arg Phe Gln Glu His Leu Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Xaa Leu Xaa Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Val Ile Ile Asp Met Asn Asp Pro Ser Asn Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Asp Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Gly Ile Lys Glu Ser Gly Lys Xaa Leu Gln Ile Phe Asn 
                85                  90                  95      


Ile Glu Met Lys Ser Lys Met Lys Ala His Xaa Met Xaa Asp Asp Val 
            100                 105                 110         


Xaa Phe Trp Lys Trp Ile Ser Leu Asn Xaa Val Ala Leu Val Xaa Asp 
        115                 120                 125             


Asn Ala Val Tyr His Trp Ser Met Glu Gly Glu Ser Gln Pro Val Lys 
    130                 135                 140                 


Met Phe Asp Arg His Ser Ser Leu Ala Gly Cys Gln Ile Ile Asn Tyr 
145                 150                 155                 160 


Arg Xaa Asp Ala Lys Gln Lys Trp Leu Leu Leu Xaa Gly Ile Ser Ala 
                165                 170                 175     


Gln Gln Asn Arg Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg 
            180                 185                 190         


Lys Val Ser Gln Pro Ile Glu Gly His Ala Ala Ser Phe Ala Gln Phe 
        195                 200                 205             


Lys Met Glu Gly Asn Ala Glu Glu Ser Xaa Leu Phe Cys Phe Ala Val 
    210                 215                 220                 


Arg Gly Gln Ala Gly Gly Lys Leu His Ile Ile Glu Val Gly Xaa Pro 
225                 230                 235                 240 


Pro Xaa Gly Asn Gln Pro Phe Pro Lys Lys Ala Val Asp Val Phe Phe 
                245                 250                 255     


Pro Pro Glu Ala Gln Asn Asp Phe Pro Val Ala Met Gln Ile Ser Glu 
            260                 265                 270         


Lys His Asp Val Val Phe Leu Ile Xaa Lys Tyr Gly Tyr Ile His Leu 
        275                 280                 285             


Tyr Asp Leu Glu Xaa Gly Xaa Cys Ile Tyr Met Asn Arg Ile Ser Gly 
    290                 295                 300                 


Glu Xaa Ile Phe Val Xaa Ala Pro His Glu Ala Xaa Ala Gly Ile Ile 
305                 310                 315                 320 


Gly Val Asn Arg Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Glu 
                325                 330                 335     


Asn Ile Ile Pro Tyr Ile Xaa Asn Val Leu Gln Asn Pro Asp Leu Ala 
            340                 345                 350         


Leu Arg Met Ala Val Arg Asn Asn Leu Ala Gly Ala Glu Glu Leu Phe 
        355                 360                 365             


Ala Arg Lys Phe Asn Ala Leu Phe Ala Gln Gly Asn Tyr Ser Glu Ala 
    370                 375                 380                 


Ala Lys Val Ala Ala Asn Ala Pro Lys Gly Ile Leu Arg Xaa Pro Asp 
385                 390                 395                 400 


Xaa Ile Arg Arg Phe Gln Ser Val Pro Ala Gln Pro Gly Gln Xaa Ser 
                405                 410                 415     


Pro Leu Leu Gln Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn 
            420                 425                 430         


Lys Tyr Glu Ser Leu Glu Leu Cys Arg Pro Val Leu Gln Gln Gly Arg 
        435                 440                 445             


Lys Gln Leu Leu Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser 
    450                 455                 460                 


Glu Glu Leu Gly Asp Leu Val Lys Ser Val Asp Pro Xaa Leu Ala Leu 
465                 470                 475                 480 


Ser Val Tyr Leu Arg Ala Asn Val Pro Asn Lys Val Ile Gln Cys Phe 
                485                 490                 495     


Ala Glu Xaa Gly Gln Val Gln Lys Ile Val Leu Tyr Ala Lys Lys Val 
            500                 505                 510         


Gly Tyr Xaa Pro Asp Trp Ile Phe Leu Leu Arg Asn Val Met Arg Ile 
        515                 520                 525             


Ser Pro Asp Gln Gly Gln Gln Phe Ala Gln Met Leu Val Gln Asp Glu 
    530                 535                 540                 


Glu Pro Leu Ala Asp Ile Xaa Gln Ile Val Asp Val Phe Met Glu Tyr 
545                 550                 555                 560 


Asn Leu Ile Gln Gln Cys Xaa Ala Phe Leu Leu Asp Ala Leu Lys Asn 
                565                 570                 575     


Asn Arg Pro Ser Glu Gly Pro Leu Gln Xaa Arg Leu Leu Glu Met Asn 
            580                 585                 590         


Leu Met His Ala Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Gln Met 
        595                 600                 605             


Phe Xaa His Tyr Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala 
    610                 615                 620                 


Gly Leu Leu Gln Arg Ala Leu Glu His Phe Xaa Asp Leu Tyr Asp Ile 
625                 630                 635                 640 


Lys Arg Ala Val Val His Xaa His Leu Leu Asn Pro Glu Trp Leu Val 
                645                 650                 655     


Asn Tyr Phe Gly Ser Leu Ser Val Glu Asp Ser Leu Glu Cys Leu Arg 
            660                 665                 670         


Ala Met Leu Ser Ala Asn Ile Arg Gln Asn Leu Gln Ile Cys Val Gln 
        675                 680                 685             


Val Ala Ser Lys Tyr His Glu Gln Leu Ser Xaa Gln Ser Leu Ile Glu 
    690                 695                 700                 


Leu Phe Glu Ser Phe Lys Ser Phe Glu Gly Leu Phe Tyr Phe Leu Gly 
705                 710                 715                 720 


Ser Ile Val Asn Phe Ser Gln Asp Pro Asp Val His Phe Lys Tyr Ile 
                725                 730                 735     


Gln Ala Ala Cys Lys Xaa Gly Gln Ile Lys Glu Val Glu Arg Ile Cys 
            740                 745                 750         


Arg Glu Ser Asn Cys Tyr Asp Pro Glu Arg Val Lys Asn Phe Leu Lys 
        755                 760                 765             


Glu Ala Lys Leu Xaa Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg 
    770                 775                 780                 


Phe Asp Phe Val His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu 
785                 790                 795                 800 


Gln Lys Tyr Ile Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Leu 
                805                 810                 815     


Pro Val Val Ile Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Asp Val 
            820                 825                 830         


Ile Lys Asn Leu Ile Leu Val Val Arg Gly Gln Phe Ser Xaa Asp Glu 
        835                 840                 845             


Leu Val Ala Glu Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro 
    850                 855                 860                 


Trp Leu Glu Ala Arg Ile His Glu Gly Cys Glu Glu Pro Ala Xaa His 
865                 870                 875                 880 


Asn Ala Leu Ala Lys Ile Tyr Ile Asp Ser Asn Asn Asn Pro Glu Arg 
                885                 890                 895     


Phe Leu Arg Glu Asn Pro Tyr Tyr Asp Ser Arg Val Val Gly Lys Tyr 
            900                 905                 910         


Cys Glu Lys Arg Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly 
        915                 920                 925             


Gln Cys Asp Leu Glu Leu Ile Asn Val Cys Asn Glu Asn Ser Leu Phe 
    930                 935                 940                 


Lys Ser Leu Ser Arg Tyr Leu Val Arg Arg Lys Asp Pro Glu Leu Trp 
945                 950                 955                 960 


Gly Ser Val Leu Leu Glu Ser Asn Pro Tyr Arg Arg Pro Leu Ile Asp 
                965                 970                 975     


Gln Val Val Gln Xaa Ala Leu Ser Glu Xaa Gln Asp Pro Glu Glu Val 
            980                 985                 990         


Ser Val Xaa Val Lys Ala Phe Met  Xaa Ala Asp Leu Pro  Asn Glu Leu 
        995                 1000                 1005             


Ile Glu  Leu Leu Glu Lys Ile  Val Leu Asp Asn Ser  Val Phe Ser 
    1010                 1015                 1020             


Glu His  Arg Asn Leu Gln Asn  Leu Leu Ile Leu Xaa  Ala Ile Lys 
    1025                 1030                 1035             


Ala Asp  Arg Xaa Arg Val Met  Glu Tyr Ile Asn Arg  Leu Asp Asn 
    1040                 1045                 1050             


Tyr Asp  Ala Pro Asp Ile Ala  Asn Ile Ala Ile Ser  Asn Glu Leu 
    1055                 1060                 1065             


Phe Glu  Glu Ala Phe Ala Ile  Phe Arg Lys Phe Asp  Val Asn Xaa 
    1070                 1075                 1080             


Ser Ala  Val Gln Val Leu Ile  Glu His Ile Gly Asn  Leu Asp Arg 
    1085                 1090                 1095             


Ala Tyr  Glu Phe Ala Glu Arg  Cys Asn Glu Pro Ala  Val Trp Ser 
    1100                 1105                 1110             


Gln Leu  Ala Lys Ala Gln Leu  Gln Lys Gly Met Val  Lys Glu Ala 
    1115                 1120                 1125             


Ile Asp  Ser Tyr Ile Lys Ala  Asp Asp Pro Ser Ser  Tyr Met Glu 
    1130                 1135                 1140             


Val Val  Gln Ala Ala Asn Xaa  Ser Gly Asn Trp Glu  Glu Leu Val 
    1145                 1150                 1155             


Lys Tyr  Leu Gln Met Ala Arg  Lys Lys Ala Arg Glu  Ser Tyr Val 
    1160                 1165                 1170             


Glu Xaa  Glu Leu Ile Phe Ala  Leu Ala Lys Xaa Asn  Arg Leu Ala 
    1175                 1180                 1185             


Glu Leu  Glu Glu Phe Ile Asn  Gly Pro Asn Asn Ala  His Ile Gln 
    1190                 1195                 1200             


Gln Val  Gly Asp Arg Cys Tyr  Asp Glu Lys Met Tyr  Asp Ala Ala 
    1205                 1210                 1215             


Lys Leu  Leu Tyr Asn Asn Val  Ser Asn Phe Gly Arg  Leu Ala Ser 
    1220                 1225                 1230             


Xaa Leu  Val His Leu Gly Glu  Tyr Gln Ala Ala Val  Asp Gly Ala 
    1235                 1240                 1245             


Arg Lys  Ala Asn Ser Xaa Arg  Xaa Trp Lys Glu Val  Cys Phe Ala 
    1250                 1255                 1260             


Cys Val  Asp Gly Lys Glu Phe  Arg Leu Ala Gln Met  Cys Gly Leu 
    1265                 1270                 1275             


His Ile  Val Val His Ala Asp  Glu Leu Glu Glu Leu  Ile Asn Tyr 
    1280                 1285                 1290             


Tyr Gln  Asp Arg Gly Tyr Phe  Glu Glu Leu Ile Xaa  Met Leu Glu 
    1295                 1300                 1305             


Ala Ala  Leu Gly Leu Glu Arg  Ala His Met Gly Met  Phe Xaa Glu 
    1310                 1315                 1320             


Leu Ala  Ile Leu Tyr Ser Lys  Phe Lys Pro Gln Lys  Met Arg Glu 
    1325                 1330                 1335             


His Leu  Glu Leu Phe Trp Ser  Arg Val Asn Ile Pro  Lys Val Leu 
    1340                 1345                 1350             


Arg Ala  Ala Glu Gln Ala His  Leu Trp Ala Glu Leu  Val Phe Leu 
    1355                 1360                 1365             


Tyr Asp  Lys Tyr Glu Glu Tyr  Asp Asn Ala Ile Ile  Xaa Met Met 
    1370                 1375                 1380             


Asn His  Pro Xaa Asp Ala Trp  Lys Glu Gly Gln Phe  Lys Asp Ile 
    1385                 1390                 1395             


Ile Xaa  Lys Val Ala Asn Val  Glu Leu Tyr Tyr Arg  Ala Ile Gln 
    1400                 1405                 1410             


Phe Tyr  Leu Glu Phe Lys Pro  Leu Leu Leu Asn Asp  Leu Leu Met 
    1415                 1420                 1425             


Val Leu  Ser Pro Arg Leu Asp  His Xaa Arg Ala Val  Asn Tyr Phe 
    1430                 1435                 1440             


Ser Lys  Val Lys Gln Leu Pro  Leu Val Lys Pro Tyr  Leu Arg Ser 
    1445                 1450                 1455             


Val Gln  Asn His Asn Asn Lys  Ser Val Asn Glu Ser  Leu Asn Asn 
    1460                 1465                 1470             


Leu Phe  Ile Xaa Glu Glu Asp  Tyr Gln Ala Leu Arg  Xaa Ser Ile 
    1475                 1480                 1485             


Asp Ala  Tyr Asp Asn Phe Asp  Asn Ile Ser Leu Ala  Gln Arg Leu 
    1490                 1495                 1500             


Glu Lys  His Glu Leu Ile Glu  Phe Arg Arg Ile Ala  Ala Tyr Leu 
    1505                 1510                 1515             


Phe Lys  Gly Asn Asn Arg Trp  Lys Gln Ser Val Glu  Leu Cys Lys 
    1520                 1525                 1530             


Lys Asp  Ser Leu Tyr Lys Asp  Ala Met Gln Tyr Ala  Ser Glu Ser 
    1535                 1540                 1545             


Lys Asp  Xaa Glu Leu Ala Glu  Glu Leu Leu Gln Trp  Phe Leu Gln 
    1550                 1555                 1560             


Glu Glu  Lys Arg Glu Cys Phe  Gly Ala Cys Leu Phe  Xaa Cys Tyr 
    1565                 1570                 1575             


Asp Leu  Leu Arg Pro Asp Val  Val Leu Glu Xaa Ala  Trp Arg His 
    1580                 1585                 1590             


Asn Ile  Met Asp Phe Ala Met  Pro Tyr Phe Ile Gln  Val Met Lys 
    1595                 1600                 1605             


Glu Tyr  Leu Xaa Lys Val Asp  Lys Leu Asp Ala Ser  Glu Ser Leu 
    1610                 1615                 1620             


Arg Lys  Glu Glu Glu Gln Ala  Xaa Glu Xaa Gln Pro  Ile Val Tyr 
    1625                 1630                 1635             


Gly Gln  Pro Gln Leu Met Leu  Xaa Ala Gly Pro Ser  Val Ala Val 
    1640                 1645                 1650             


Pro Pro  Gln Ala Pro Phe Gly  Tyr Gly Tyr Xaa Ala  Pro Pro Tyr 
    1655                 1660                 1665             


Gly Gln  Pro Gln Pro Gly Phe  Gly Tyr Ser Met 
    1670                 1675                 


<210> 6414
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<400> 6414
Xaa Glu Lys His Glu Leu Ile Glu Phe Arg Arg Ile Ala Ala Tyr Leu 
1               5                   10                  15      


Phe Lys Gly Asn Asn Arg Trp Lys Gln Ser Val Glu Leu Cys Lys Lys 
            20                  25                  30          


Asp Ser Leu Tyr Lys Asp Ala Met Gln Tyr Ala Ser Glu Ser Lys Asp 
        35                  40                  45              


Xaa Glu Leu Ala Glu Glu Leu Leu Gln Trp Phe Leu Gln Glu Glu Lys 
    50                  55                  60                  


Arg Glu Cys Phe Gly Ala Cys Leu Phe Xaa Cys Tyr Asp Leu Leu Arg 
65                  70                  75                  80  


Pro Asp Val Val Leu Glu Xaa Ala Trp Arg His Asn Ile Met Asp Phe 
                85                  90                  95      


Ala Met Pro Tyr Phe Ile Gln Val Met Lys Glu Tyr Leu Xaa Lys Val 
            100                 105                 110         


Asp Ala Ile Lys Glu Lys Val Lys Val Asp Ser Leu Xaa Ser Leu Ser 
        115                 120                 125             


Leu Glu Asp 
    130     


<210> 6415
<211> 222
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<400> 6415
Xaa Arg Ser Val Gln Asn His Asn Asn Lys Ser Val Asn Glu Ser Leu 
1               5                   10                  15      


Asn Asn Leu Phe Ile Xaa Glu Glu Asp Tyr Gln Ala Leu Arg Xaa Ser 
            20                  25                  30          


Ile Asp Ala Tyr Asp Asn Phe Asp Asn Ile Ser Leu Ala Gln Arg Leu 
        35                  40                  45              


Glu Lys His Glu Leu Ile Glu Phe Arg Arg Ile Ala Ala Tyr Leu Phe 
    50                  55                  60                  


Lys Gly Asn Asn Arg Trp Lys Gln Ser Val Glu Leu Cys Lys Lys Asp 
65                  70                  75                  80  


Ser Leu Tyr Lys Asp Ala Met Gln Tyr Ala Ser Glu Ser Lys Asp Xaa 
                85                  90                  95      


Glu Leu Ala Glu Glu Leu Leu Gln Trp Phe Leu Gln Glu Glu Lys Arg 
            100                 105                 110         


Glu Cys Phe Gly Ala Cys Leu Phe Xaa Cys Tyr Asp Leu Leu Arg Pro 
        115                 120                 125             


Asp Val Val Leu Glu Xaa Ala Trp Arg His Asn Ile Met Asp Phe Ala 
    130                 135                 140                 


Met Pro Tyr Phe Ile Gln Val Met Lys Glu Tyr Leu Xaa Lys Val Asp 
145                 150                 155                 160 


Ala Ile Lys Glu Lys Val Asp Lys Leu Asp Ala Ser Glu Ser Leu Arg 
                165                 170                 175     


Lys Glu Glu Glu Gln Ala Xaa Glu Xaa Gln Pro Ile Val Tyr Gly Gln 
            180                 185                 190         


Pro Gln Leu Met Leu Xaa Ala Gly Pro Ser Val Ala Val Pro Pro Gln 
        195                 200                 205             


Ala Pro Phe Gly Tyr Gly Tyr Xaa Ala Pro Pro Tyr Gly Gln 
    210                 215                 220         


<210> 6416
<211> 24
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<400> 6416
Xaa Xaa Ile Phe Val Xaa Ala Pro His Glu Ala Xaa Ala Gly Ile Ile 
1               5                   10                  15      


Gly Val Asn Arg Lys Gly Gln Asn 
            20                  


<210> 6417
<211> 67
<212> PRT
<213> Homo sapiens

<400> 6417
Gly Leu Arg Ala Ser Ile Asp Ala Tyr Asp Asn Phe Asp Asn Ile Ser 
1               5                   10                  15      


Leu Ala Gln Gln Leu Glu Lys His Gln Leu Met Glu Phe Arg Cys Ile 
            20                  25                  30          


Ala Ala Tyr Leu Tyr Lys Gly Asn Asn Trp Trp Ala Gln Ser Val Glu 
        35                  40                  45              


Leu Cys Lys Lys Asp His Leu Tyr Lys Glu Gln Cys Gly Ser Gly Gly 
    50                  55                  60                  


Ser Asp Arg 
65          


<210> 6418
<211> 43
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<400> 6418
Leu Cys Glu Lys Ala Gly Leu Leu Gln Gln Ala Leu Glu His Tyr Xaa 
1               5                   10                  15      


Asp Leu Tyr Asp Ile Lys Arg Ala Val Val His Xaa His Leu Leu Asn 
            20                  25                  30          


Pro Glu Ala Ser Ser Xaa Ser Trp Ala Gln Ser 
        35                  40              


<210> 6419
<211> 1260
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1243)..(1243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<400> 6419
Met Ala Gln Ile Leu Pro Val Arg Phe Gln Glu His Phe Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Xaa Leu Xaa Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Xaa Ile Ile Asp Met Ser Asp Pro Met Ala Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Glu Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Xaa Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Xaa Met Ala Glu Glu Val Ile Phe Trp Lys 
            100                 105                 110         


Trp Val Ser Val Asn Xaa Val Ala Leu Val Xaa Glu Xaa Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Asp Ser Gln Pro Met Lys Met Phe Asp Arg 
    130                 135                 140                 


His Xaa Ser Leu Val Gly Cys Gln Val Ile His Tyr Arg Xaa Asp Glu 
145                 150                 155                 160 


Tyr Gln Lys Trp Leu Leu Leu Val Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ala Phe Ala Glu Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Lys Pro Ala Xaa Leu Phe Cys Phe Ala Val Arg Asn Pro Xaa 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Gln Pro Ala Ala Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Val Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Gly Ala Lys His Gly Val 
            260                 265                 270         


Ile Tyr Leu Ile Xaa Lys Tyr Gly Tyr Leu His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Ser Gly Val Cys Ile Cys Met Asn Arg Ile Ser Ala Asp Xaa Ile Phe 
    290                 295                 300                 


Val Xaa Ala Pro His Lys Pro Xaa Ser Gly Ile Ile Gly Val Asn Lys 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Asp Asn Ile Val Asn 
                325                 330                 335     


Tyr Ala Xaa Asn Val Leu Gln Asn Pro Asp Leu Gly Leu Arg Leu Ala 
            340                 345                 350         


Val Arg Ser Asn Leu Ala Gly Ala Glu Lys Leu Phe Val Arg Lys Phe 
        355                 360                 365             


Asn Xaa Leu Phe Ala Gln Gly Ser Tyr Ala Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Ser Ala Pro Lys Gly Ile Leu Arg Xaa Arg Glu Xaa Val Gln Lys 
385                 390                 395                 400 


Phe Gln Ser Ile Pro Ala Gln Ser Gly Gln Ala Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Leu Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys His Leu Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Xaa Xaa Asp Pro Met Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Ser Lys Val Ile Gln Cys Phe Ala Glu Xaa Gly 
                485                 490                 495     


Gln Phe Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Xaa Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Gly Val Met Lys Ile Ser Pro Glu Gln 
        515                 520                 525             


Gly Leu Gln Phe Ser Arg Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asn Ile Ser Gln Ile Val Asp Ile Phe Met Glu Asn Ser Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Xaa Ser Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ala 
                565                 570                 575     


Glu Gly Leu Leu Gln Xaa Trp Leu Leu Glu Met Asn Leu Val His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Lys Met Phe Xaa His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Gln Ala Leu Glu His Tyr Xaa Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Xaa His Leu Leu Asn Pro Glu Trp Leu Val Asn Phe Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Val Glu Cys Leu His Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Leu Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Glu Gln Leu Gly Xaa Gln Ala Leu Val Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Tyr Lys Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Leu Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Xaa Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Ser 
            740                 745                 750         


Cys Tyr Asn Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Xaa Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Gly Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Arg Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Xaa Pro Ala Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Glu Val Ile Lys His Leu 
            820                 825                 830         


Ile Met Ala Val Arg Gly Gln Phe Ser Xaa Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ser 
    850                 855                 860                 


Gln Ile Gln Glu Gly Cys Glu Glu Pro Ala Xaa His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Ser Pro Glu Cys Phe Leu Arg Glu 
                885                 890                 895     


Asn Ala Tyr Tyr Asp Ser Ser Val Val Gly Arg Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Lys Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Glu Ala 
    930                 935                 940                 


Arg Tyr Leu Val Cys Arg Lys Asp Pro Glu Leu Trp Ala His Val Leu 
945                 950                 955                 960 


Glu Glu Xaa Asn Pro Ser Arg Arg Gln Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Xaa Ala Leu Ser Glu Xaa Arg Asp Pro Glu Glu Ile Ser Val Xaa Val 
            980                 985                 990         


Lys Ala Phe Met Xaa Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Xaa Ala Ile Lys Ala  Asp Arg Xaa 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Ser  Arg Leu Asp Asn Tyr  Asp Ala Leu 
    1040                 1045                 1050             


Asp Ile  Ala Ser Ile Ala Val  Ser Ser Ala Leu Tyr  Glu Glu Ala 
    1055                 1060                 1065             


Phe Xaa  Val Phe His Lys Phe  Asp Met Asn Ala Ser  Ala Ile Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Gln 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Asp Leu  Val Lys Glu Ala Ile  Asn Ser Tyr 
    1115                 1120                 1125             


Ile Arg  Gly Asp Asp Pro Ser  Ser Tyr Leu Glu Val  Val Gln Ser 
    1130                 1135                 1140             


Ala Ser  Arg Ser Asn Asn Trp  Glu Asp Leu Val Lys  Phe Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Gly Arg  Glu Ser Tyr Ile Glu  Xaa Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Xaa  Ser Arg Val Ser Glu  Leu Glu Asp 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Glu Glu Gly Met  Tyr Glu Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Ser Asn  Val Ser Asn Phe Ala  Arg Leu Ala Ser Xaa  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Val Leu Cys Leu His  Gly Trp Xaa Arg Val  Pro Leu Arg 
    1235                 1240                 1245             


Xaa Ala  Val Trp Ser Ser His  Arg His Ser Cys Arg  
    1250                 1255                 1260 


<210> 6420
<211> 1583
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1252)..(1252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1377)..(1377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1383)..(1383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1396)..(1396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1433)..(1433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1435)..(1435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1515)..(1515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1570)..(1570)
<223> Selenocysteine

<400> 6420
Met Ala Gln Ile Leu Pro Val Arg Phe Gln Glu His Phe Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Xaa Leu Xaa Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Xaa Ile Ile Asp Met Ser Asp Pro Met Ala Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Glu Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Xaa Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Xaa Met Ala Glu Glu Val Ile Phe Trp Lys 
            100                 105                 110         


Trp Val Ser Val Asn Xaa Val Ala Leu Val Xaa Glu Xaa Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Asp Ser Gln Pro Met Lys Met Phe Asp Arg 
    130                 135                 140                 


His Xaa Ser Leu Val Gly Cys Gln Val Ile His Tyr Arg Xaa Asp Glu 
145                 150                 155                 160 


Tyr Gln Lys Trp Leu Leu Leu Val Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ala Phe Ala Glu Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Lys Pro Ala Xaa Leu Phe Cys Phe Ala Val Arg Asn Pro Xaa 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Gln Pro Ala Ala Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Val Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Gly Ala Lys His Gly Val 
            260                 265                 270         


Ile Tyr Leu Ile Xaa Lys Tyr Gly Tyr Leu His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Ser Gly Val Cys Ile Cys Met Asn Arg Ile Ser Ala Asp Xaa Ile Phe 
    290                 295                 300                 


Val Xaa Ala Pro His Lys Pro Xaa Ser Gly Ile Ile Gly Val Asn Lys 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Asp Asn Ile Val Asn 
                325                 330                 335     


Tyr Ala Xaa Asn Val Leu Gln Asn Pro Asp Leu Gly Leu Arg Leu Ala 
            340                 345                 350         


Val Arg Ser Asn Leu Ala Gly Ala Glu Lys Leu Phe Val Arg Lys Phe 
        355                 360                 365             


Asn Xaa Leu Phe Ala Gln Gly Ser Tyr Ala Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Ser Ala Pro Lys Gly Ile Leu Arg Xaa Arg Glu Xaa Val Gln Lys 
385                 390                 395                 400 


Phe Gln Ser Ile Pro Ala Gln Ser Gly Gln Ala Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Leu Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys His Leu Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Xaa Xaa Asp Pro Met Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Ser Lys Val Ile Gln Cys Phe Ala Glu Xaa Gly 
                485                 490                 495     


Gln Phe Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Xaa Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Gly Val Met Lys Ile Ser Pro Glu Gln 
        515                 520                 525             


Gly Leu Gln Phe Ser Arg Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asn Ile Ser Gln Ile Val Asp Ile Phe Met Glu Asn Ser Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Xaa Ser Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ala 
                565                 570                 575     


Glu Gly Leu Leu Gln Xaa Trp Leu Leu Glu Met Asn Leu Val His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Lys Met Phe Xaa His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Gln Ala Leu Glu His Tyr Xaa Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Xaa His Leu Leu Asn Pro Glu Trp Leu Val Asn Phe Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Val Glu Cys Leu His Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Leu Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Glu Gln Leu Gly Xaa Gln Ala Leu Val Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Tyr Lys Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Leu Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Xaa Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Ser 
            740                 745                 750         


Cys Tyr Asn Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Xaa Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Gly Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Arg Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Xaa Pro Ala Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Glu Val Ile Lys His Leu 
            820                 825                 830         


Ile Met Ala Val Arg Gly Gln Phe Ser Xaa Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ser 
    850                 855                 860                 


Gln Ile Gln Glu Gly Cys Glu Glu Pro Ala Xaa His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Ser Pro Glu Cys Phe Leu Arg Glu 
                885                 890                 895     


Asn Ala Tyr Tyr Asp Ser Ser Val Val Gly Arg Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Lys Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Glu Ala 
    930                 935                 940                 


Arg Tyr Leu Val Cys Arg Lys Asp Pro Glu Leu Trp Ala His Val Leu 
945                 950                 955                 960 


Glu Glu Xaa Asn Pro Ser Arg Arg Gln Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Xaa Ala Leu Ser Glu Xaa Arg Asp Pro Glu Glu Ile Ser Val Xaa Val 
            980                 985                 990         


Lys Ala Phe Met Xaa Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Xaa Ala Ile Lys Ala  Asp Arg Xaa 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Ser  Arg Leu Asp Asn Tyr  Asp Ala Leu 
    1040                 1045                 1050             


Asp Ile  Ala Ser Ile Ala Val  Ser Ser Ala Leu Tyr  Glu Glu Ala 
    1055                 1060                 1065             


Phe Xaa  Val Phe His Lys Phe  Asp Met Asn Ala Ser  Ala Ile Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Gln 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Asp Leu  Val Lys Glu Ala Ile  Asn Ser Tyr 
    1115                 1120                 1125             


Ile Arg  Gly Asp Asp Pro Ser  Ser Tyr Leu Glu Val  Val Gln Ser 
    1130                 1135                 1140             


Ala Ser  Arg Ser Asn Asn Trp  Glu Asp Leu Val Lys  Phe Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Gly Arg  Glu Ser Tyr Ile Glu  Xaa Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Xaa  Ser Arg Val Ser Glu  Leu Glu Asp 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Glu Glu Gly Met  Tyr Glu Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Ser Asn  Val Ser Asn Phe Ala  Arg Leu Ala Ser Xaa  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Glu Tyr Gln Ala Ala  Val Asp Asn Ser Arg  Lys Ala Ser 
    1235                 1240                 1245             


Ser Xaa  Arg Xaa Trp Lys Glu  Val Cys Phe Ala Cys  Met Asp Gly 
    1250                 1255                 1260             


Gln Glu  Phe Arg Phe Ala Gln  Leu Cys Gly Leu His  Ile Val Ile 
    1265                 1270                 1275             


His Ala  Asp Glu Leu Glu Glu  Leu Met Cys Tyr Tyr  Gln Asp Arg 
    1280                 1285                 1290             


Gly Tyr  Phe Glu Glu Leu Ile  Leu Leu Leu Glu Ala  Ala Leu Gly 
    1295                 1300                 1305             


Leu Glu  Arg Ala His Met Gly  Met Phe Xaa Glu Leu  Ala Ile Leu 
    1310                 1315                 1320             


Tyr Ser  Lys Phe Lys Pro Gln  Lys Met Leu Glu His  Leu Glu Leu 
    1325                 1330                 1335             


Phe Trp  Ser Arg Val Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu 
    1340                 1345                 1350             


Gln Ala  His Leu Trp Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr 
    1355                 1360                 1365             


Glu Glu  Tyr Asp Asn Ala Val  Leu Xaa Met Met Ser  His Pro Xaa 
    1370                 1375                 1380             


Glu Ala  Trp Lys Glu Gly Gln  Phe Lys Asp Ile Ile  Xaa Lys Val 
    1385                 1390                 1395             


Ala Asn  Val Glu Leu Cys Tyr  Arg Ala Leu Gln Phe  Tyr Leu Asp 
    1400                 1405                 1410             


Tyr Lys  Pro Leu Leu Ile Asn  Asp Leu Leu Leu Val  Leu Ser Pro 
    1415                 1420                 1425             


Arg Leu  Asp His Xaa Trp Xaa  Val Ser Phe Phe Ser  Lys Ala Gly 
    1430                 1435                 1440             


Gln Leu  Pro Leu Val Lys Pro  Tyr Leu Arg Ser Val  Gln Ser His 
    1445                 1450                 1455             


Asn Asn  Lys Ser Val Asn Glu  Ala Leu Asn His Leu  Leu Xaa Glu 
    1460                 1465                 1470             


Glu Glu  Asp Tyr Gln Asp Ala  Met Gln His Ala Ala  Glu Ser Arg 
    1475                 1480                 1485             


Asp Ala  Glu Leu Ala Gln Lys  Leu Leu Gln Trp Phe  Leu Glu Glu 
    1490                 1495                 1500             


Gly Lys  Arg Glu Cys Phe Ala  Ala Cys Leu Phe Xaa  Cys Tyr Asp 
    1505                 1510                 1515             


Leu Leu  Arg Pro Asp Met Val  Leu Glu Leu Ala Trp  Arg His Asn 
    1520                 1525                 1530             


Leu Val  Asp Leu Ala Met Pro  Tyr Phe Ile Gln Val  Met Arg Glu 
    1535                 1540                 1545             


Tyr Leu  Ser Lys Val Asp Lys  Leu Asp Ala Leu Glu  Ser Leu Arg 
    1550                 1555                 1560             


Lys Gln  Glu Glu His Val Xaa  Glu Pro Ala Pro Leu  Val Phe Asp 
    1565                 1570                 1575             


Phe Asp  Gly His Glu 
    1580             


<210> 6421
<211> 1640
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1180)..(1180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1252)..(1252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1318)..(1318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1377)..(1377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1383)..(1383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1396)..(1396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1433)..(1433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1435)..(1435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1572)..(1572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1627)..(1627)
<223> Selenocysteine

<400> 6421
Met Ala Gln Ile Leu Pro Val Arg Phe Gln Glu His Phe Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Xaa Leu Xaa Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Xaa Ile Ile Asp Met Ser Asp Pro Met Ala Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Glu Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Xaa Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Xaa Met Ala Glu Glu Val Ile Phe Trp Lys 
            100                 105                 110         


Trp Val Ser Val Asn Xaa Val Ala Leu Val Xaa Glu Xaa Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Asp Ser Gln Pro Met Lys Met Phe Asp Arg 
    130                 135                 140                 


His Xaa Ser Leu Val Gly Cys Gln Val Ile His Tyr Arg Xaa Asp Glu 
145                 150                 155                 160 


Tyr Gln Lys Trp Leu Leu Leu Val Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ala Phe Ala Glu Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Lys Pro Ala Xaa Leu Phe Cys Phe Ala Val Arg Asn Pro Xaa 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Gln Pro Ala Ala Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Val Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Gly Ala Lys His Gly Val 
            260                 265                 270         


Ile Tyr Leu Ile Xaa Lys Tyr Gly Tyr Leu His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Ser Gly Val Cys Ile Cys Met Asn Arg Ile Ser Ala Asp Xaa Ile Phe 
    290                 295                 300                 


Val Xaa Ala Pro His Lys Pro Xaa Ser Gly Ile Ile Gly Val Asn Lys 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Asp Asn Ile Val Asn 
                325                 330                 335     


Tyr Ala Xaa Asn Val Leu Gln Asn Pro Asp Leu Gly Leu Arg Leu Ala 
            340                 345                 350         


Val Arg Ser Asn Leu Ala Gly Ala Glu Lys Leu Phe Val Arg Lys Phe 
        355                 360                 365             


Asn Xaa Leu Phe Ala Gln Gly Ser Tyr Ala Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Ser Ala Pro Lys Gly Ile Leu Arg Xaa Arg Glu Xaa Val Gln Lys 
385                 390                 395                 400 


Phe Gln Ser Ile Pro Ala Gln Ser Gly Gln Ala Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Leu Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys His Leu Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Xaa Xaa Asp Pro Met Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Ser Lys Val Ile Gln Cys Phe Ala Glu Xaa Gly 
                485                 490                 495     


Gln Phe Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Xaa Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Gly Val Met Lys Ile Ser Pro Glu Gln 
        515                 520                 525             


Gly Leu Gln Phe Ser Arg Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asn Ile Ser Gln Ile Val Asp Ile Phe Met Glu Asn Ser Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Xaa Ser Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ala 
                565                 570                 575     


Glu Gly Leu Leu Gln Xaa Trp Leu Leu Glu Met Asn Leu Val His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Lys Met Phe Xaa His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Gln Ala Leu Glu His Tyr Xaa Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Xaa His Leu Leu Asn Pro Glu Trp Leu Val Asn Phe Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Val Glu Cys Leu His Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Leu Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Glu Gln Leu Gly Xaa Gln Ala Leu Val Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Tyr Lys Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Leu Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Xaa Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Ser 
            740                 745                 750         


Cys Tyr Asn Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Xaa Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Gly Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Arg Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Xaa Pro Ala Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Glu Val Ile Lys His Leu 
            820                 825                 830         


Ile Met Ala Val Arg Gly Gln Phe Ser Xaa Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ser 
    850                 855                 860                 


Gln Ile Gln Glu Gly Cys Glu Glu Pro Ala Xaa His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Ser Pro Glu Cys Phe Leu Arg Glu 
                885                 890                 895     


Asn Ala Tyr Tyr Asp Ser Ser Val Val Gly Arg Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Lys Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Glu Ala 
    930                 935                 940                 


Arg Tyr Leu Val Cys Arg Lys Asp Pro Glu Leu Trp Ala His Val Leu 
945                 950                 955                 960 


Glu Glu Xaa Asn Pro Ser Arg Arg Gln Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Xaa Ala Leu Ser Glu Xaa Arg Asp Pro Glu Glu Ile Ser Val Xaa Val 
            980                 985                 990         


Lys Ala Phe Met Xaa Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Xaa Ala Ile Lys Ala  Asp Arg Xaa 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Ser  Arg Leu Asp Asn Tyr  Asp Ala Leu 
    1040                 1045                 1050             


Asp Ile  Ala Ser Ile Ala Val  Ser Ser Ala Leu Tyr  Glu Glu Ala 
    1055                 1060                 1065             


Phe Xaa  Val Phe His Lys Phe  Asp Met Asn Ala Ser  Ala Ile Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Gln 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Asp Leu  Val Lys Glu Ala Ile  Asn Ser Tyr 
    1115                 1120                 1125             


Ile Arg  Gly Asp Asp Pro Ser  Ser Tyr Leu Glu Val  Val Gln Ser 
    1130                 1135                 1140             


Ala Ser  Arg Ser Asn Asn Trp  Glu Asp Leu Val Lys  Phe Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Gly Arg  Glu Ser Tyr Ile Glu  Xaa Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Xaa  Ser Arg Val Ser Glu  Leu Glu Asp 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Glu Glu Gly Met  Tyr Glu Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Ser Asn  Val Ser Asn Phe Ala  Arg Leu Ala Ser Xaa  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Glu Tyr Gln Ala Ala  Val Asp Asn Ser Arg  Lys Ala Ser 
    1235                 1240                 1245             


Ser Xaa  Arg Xaa Trp Lys Glu  Val Cys Phe Ala Cys  Met Asp Gly 
    1250                 1255                 1260             


Gln Glu  Phe Arg Phe Ala Gln  Leu Cys Gly Leu His  Ile Val Ile 
    1265                 1270                 1275             


His Ala  Asp Glu Leu Glu Glu  Leu Met Cys Tyr Tyr  Gln Asp Arg 
    1280                 1285                 1290             


Gly Tyr  Phe Glu Glu Leu Ile  Leu Leu Leu Glu Ala  Ala Leu Gly 
    1295                 1300                 1305             


Leu Glu  Arg Ala His Met Gly  Met Phe Xaa Glu Leu  Ala Ile Leu 
    1310                 1315                 1320             


Tyr Ser  Lys Phe Lys Pro Gln  Lys Met Leu Glu His  Leu Glu Leu 
    1325                 1330                 1335             


Phe Trp  Ser Arg Val Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu 
    1340                 1345                 1350             


Gln Ala  His Leu Trp Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr 
    1355                 1360                 1365             


Glu Glu  Tyr Asp Asn Ala Val  Leu Xaa Met Met Ser  His Pro Xaa 
    1370                 1375                 1380             


Glu Ala  Trp Lys Glu Gly Gln  Phe Lys Asp Ile Ile  Xaa Lys Val 
    1385                 1390                 1395             


Ala Asn  Val Glu Leu Cys Tyr  Arg Ala Leu Gln Phe  Tyr Leu Asp 
    1400                 1405                 1410             


Tyr Lys  Pro Leu Leu Ile Asn  Asp Leu Leu Leu Val  Leu Ser Pro 
    1415                 1420                 1425             


Arg Leu  Asp His Xaa Trp Xaa  Val Ser Phe Phe Ser  Lys Ala Gly 
    1430                 1435                 1440             


Gln Leu  Pro Leu Val Lys Pro  Tyr Leu Arg Ser Val  Gln Ser His 
    1445                 1450                 1455             


Asn Asn  Lys Ser Val Asn Glu  Ala Leu Asn His Leu  Leu Xaa Glu 
    1460                 1465                 1470             


Glu Glu  Asp Tyr Gln Gly Leu  Arg Ala Ser Ile Asp  Ala Tyr Asp 
    1475                 1480                 1485             


Asn Phe  Asp Asn Ile Ser Leu  Ala Gln Gln Leu Glu  Lys His Gln 
    1490                 1495                 1500             


Leu Met  Glu Phe Arg Cys Ile  Ala Ala Tyr Leu Tyr  Lys Gly Asn 
    1505                 1510                 1515             


Asn Trp  Trp Ala Gln Ser Val  Glu Leu Cys Lys Lys  Asp His Leu 
    1520                 1525                 1530             


Tyr Lys  Asp Ala Met Gln His  Ala Ala Glu Ser Arg  Asp Ala Glu 
    1535                 1540                 1545             


Leu Ala  Gln Lys Leu Leu Gln  Trp Phe Leu Glu Glu  Gly Lys Arg 
    1550                 1555                 1560             


Glu Cys  Phe Ala Ala Cys Leu  Phe Xaa Cys Tyr Asp  Leu Leu Arg 
    1565                 1570                 1575             


Pro Asp  Met Val Leu Glu Leu  Ala Trp Arg His Asn  Leu Val Asp 
    1580                 1585                 1590             


Leu Ala  Met Pro Tyr Phe Ile  Gln Val Met Arg Glu  Tyr Leu Ser 
    1595                 1600                 1605             


Lys Val  Asp Lys Leu Asp Ala  Leu Glu Ser Leu Arg  Lys Gln Glu 
    1610                 1615                 1620             


Glu His  Val Xaa Glu Pro Ala  Pro Leu Val Phe Asp  Phe Asp Gly 
    1625                 1630                 1635             


His Glu  
    1640 


<210> 6422
<211> 169
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<400> 6422
Met Ala Gln Ile Leu Pro Val Arg Phe Gln Glu His Phe Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Xaa Leu Xaa Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Xaa Ile Ile Asp Met Ser Asp Pro Met Ala Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Glu Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Gly Ala Pro Gly Phe Cys Ser Pro Ala Ser Asn Ser Gln 
                85                  90                  95      


Ser Pro Gly Ser Ser Leu Cys Pro Ala Gly Lys Xaa Leu Gln Ile Phe 
            100                 105                 110         


Asn Ile Glu Met Lys Ser Lys Met Lys Ala His Xaa Met Ala Glu Glu 
        115                 120                 125             


Val Ile Phe Trp Lys Trp Val Ser Val Asn Xaa Val Ala Leu Val Xaa 
    130                 135                 140                 


Glu Xaa Ala Val Tyr His Trp Ser Met Glu Gly Asp Ser Gln Pro Met 
145                 150                 155                 160 


Lys Met Phe Asp Arg His Xaa Ser Leu 
                165                 


<210> 6423
<211> 369
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<400> 6423
Met Gly Val Gly Asp Arg Cys Phe Ser Val Met Gln Ile Lys Ile Met 
1               5                   10                  15      


Arg Ser Lys Pro His Glu Glu Val Gly Asp Arg Cys Tyr Glu Glu Gly 
            20                  25                  30          


Met Tyr Glu Ala Ala Lys Leu Leu Tyr Ser Asn Val Ser Asn Phe Ala 
        35                  40                  45              


Arg Leu Ala Ser Xaa Leu Val His Leu Gly Glu Tyr Gln Ala Ala Val 
    50                  55                  60                  


Asp Asn Ser Arg Lys Ala Ser Ser Xaa Arg Xaa Trp Lys Glu Val Cys 
65                  70                  75                  80  


Phe Ala Cys Met Asp Gly Gln Glu Phe Arg Phe Ala Gln Leu Cys Gly 
                85                  90                  95      


Leu His Ile Val Ile His Ala Asp Glu Leu Glu Glu Leu Met Cys Tyr 
            100                 105                 110         


Tyr Gln Asp Arg Gly Tyr Phe Glu Glu Leu Ile Leu Leu Leu Glu Ala 
        115                 120                 125             


Ala Leu Gly Leu Glu Arg Ala His Met Gly Met Phe Xaa Glu Leu Ala 
    130                 135                 140                 


Ile Leu Tyr Ser Lys Phe Lys Pro Gln Lys Met Leu Glu His Leu Glu 
145                 150                 155                 160 


Leu Phe Trp Ser Arg Val Asn Ile Pro Lys Val Leu Arg Ala Ala Glu 
                165                 170                 175     


Gln Ala His Leu Trp Ala Glu Leu Val Phe Leu Tyr Asp Lys Tyr Glu 
            180                 185                 190         


Glu Tyr Asp Asn Ala Val Leu Xaa Met Met Ser His Pro Xaa Glu Ala 
        195                 200                 205             


Trp Lys Glu Gly Gln Phe Lys Asp Ile Ile Xaa Lys Val Ala Asn Val 
    210                 215                 220                 


Glu Leu Cys Tyr Arg Ala Leu Gln Phe Tyr Leu Asp Tyr Lys Pro Leu 
225                 230                 235                 240 


Leu Ile Asn Asp Leu Leu Leu Val Leu Ser Pro Arg Leu Asp His Xaa 
                245                 250                 255     


Trp Xaa Val Ser Phe Phe Ser Lys Asp Ala Met Gln His Ala Ala Glu 
            260                 265                 270         


Ser Arg Asp Ala Glu Leu Ala Gln Lys Leu Leu Gln Trp Phe Leu Glu 
        275                 280                 285             


Glu Gly Lys Arg Glu Cys Phe Ala Ala Cys Leu Phe Xaa Cys Tyr Asp 
    290                 295                 300                 


Leu Leu Arg Pro Asp Met Val Leu Glu Leu Ala Trp Arg His Asn Leu 
305                 310                 315                 320 


Val Asp Leu Ala Met Pro Tyr Phe Ile Gln Val Met Arg Glu Tyr Leu 
                325                 330                 335     


Ser Lys Val Asp Lys Leu Asp Ala Leu Glu Ser Leu Arg Lys Gln Glu 
            340                 345                 350         


Glu His Val Xaa Glu Pro Ala Pro Leu Val Phe Asp Phe Asp Gly His 
        355                 360                 365             


Glu 
    


<210> 6424
<211> 463
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<400> 6424
Met Gly Val Gly Asp Arg Cys Phe Ser Val Met Gln Ile Lys Ile Met 
1               5                   10                  15      


Arg Ser Lys Pro His Glu Glu Val Gly Asp Arg Cys Tyr Glu Glu Gly 
            20                  25                  30          


Met Tyr Glu Ala Ala Lys Leu Leu Tyr Ser Asn Val Ser Asn Phe Ala 
        35                  40                  45              


Arg Leu Ala Ser Xaa Leu Val His Leu Gly Glu Tyr Gln Ala Ala Val 
    50                  55                  60                  


Asp Asn Ser Arg Lys Ala Ser Ser Xaa Arg Xaa Trp Lys Glu Val Cys 
65                  70                  75                  80  


Phe Ala Cys Met Asp Gly Gln Glu Phe Arg Phe Ala Gln Leu Cys Gly 
                85                  90                  95      


Leu His Ile Val Ile His Ala Asp Glu Leu Glu Glu Leu Met Cys Tyr 
            100                 105                 110         


Tyr Gln Asp Arg Gly Tyr Phe Glu Glu Leu Ile Leu Leu Leu Glu Ala 
        115                 120                 125             


Ala Leu Gly Leu Glu Arg Ala His Met Gly Met Phe Xaa Glu Leu Ala 
    130                 135                 140                 


Ile Leu Tyr Ser Lys Phe Lys Pro Gln Lys Met Leu Glu His Leu Glu 
145                 150                 155                 160 


Leu Phe Trp Ser Arg Val Asn Ile Pro Lys Val Leu Arg Ala Ala Glu 
                165                 170                 175     


Gln Ala His Leu Trp Ala Glu Leu Val Phe Leu Tyr Asp Lys Tyr Glu 
            180                 185                 190         


Glu Tyr Asp Asn Ala Val Leu Xaa Met Met Ser His Pro Xaa Glu Ala 
        195                 200                 205             


Trp Lys Glu Gly Gln Phe Lys Asp Ile Ile Xaa Lys Val Ala Asn Val 
    210                 215                 220                 


Glu Leu Cys Tyr Arg Ala Leu Gln Phe Tyr Leu Asp Tyr Lys Pro Leu 
225                 230                 235                 240 


Leu Ile Asn Asp Leu Leu Leu Val Leu Ser Pro Arg Leu Asp His Xaa 
                245                 250                 255     


Trp Xaa Val Ser Phe Phe Ser Lys Ala Gly Gln Leu Pro Leu Val Lys 
            260                 265                 270         


Pro Tyr Leu Arg Ser Val Gln Ser His Asn Asn Lys Ser Val Asn Glu 
        275                 280                 285             


Ala Leu Asn His Leu Leu Xaa Glu Glu Glu Asp Tyr Gln Gly Leu Arg 
    290                 295                 300                 


Ala Ser Ile Asp Ala Tyr Asp Asn Phe Asp Asn Ile Ser Leu Ala Gln 
305                 310                 315                 320 


Gln Leu Glu Lys His Gln Leu Met Glu Phe Arg Cys Ile Ala Ala Tyr 
                325                 330                 335     


Leu Tyr Lys Gly Asn Asn Trp Trp Ala Gln Ser Val Glu Leu Cys Lys 
            340                 345                 350         


Lys Asp His Leu Tyr Lys Asp Ala Met Gln His Ala Ala Glu Ser Arg 
        355                 360                 365             


Asp Ala Glu Leu Ala Gln Lys Leu Leu Gln Trp Phe Leu Glu Glu Gly 
    370                 375                 380                 


Lys Arg Glu Cys Phe Ala Ala Cys Leu Phe Xaa Cys Tyr Asp Leu Leu 
385                 390                 395                 400 


Arg Pro Asp Met Val Leu Glu Leu Ala Trp Arg His Asn Leu Val Asp 
                405                 410                 415     


Leu Ala Met Pro Tyr Phe Ile Gln Val Met Arg Glu Tyr Leu Ser Lys 
            420                 425                 430         


Val Asp Lys Leu Asp Ala Leu Glu Ser Leu Arg Lys Gln Glu Glu His 
        435                 440                 445             


Val Xaa Glu Pro Ala Pro Leu Val Phe Asp Phe Asp Gly His Glu 
    450                 455                 460             


<210> 6425
<211> 297
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<400> 6425
Met Glu Ala Cys Lys Asp Ser Arg Ile Gly Gly Met Met Lys Xaa Leu 
1               5                   10                  15      


Leu Leu Phe Val Gly Leu Leu Leu Xaa Trp Glu Ser Gly Gln Val Leu 
            20                  25                  30          


Gly Asp Gln Xaa Val Ser Asp Asn Glu Leu Gln Glu Met Ser Asn Gln 
        35                  40                  45              


Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn Ala Val Asn Gly Val 
    50                  55                  60                  


Lys Gln Ile Lys Xaa Leu Ile Glu Lys Xaa Asn Glu Glu Arg Lys Xaa 
65                  70                  75                  80  


Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys Lys Glu Asp Ala Leu 
                85                  90                  95      


Asn Glu Xaa Arg Glu Ser Glu Xaa Lys Leu Lys Glu Leu Pro Gly Val 
            100                 105                 110         


Cys Asn Glu Xaa Met Met Ala Leu Trp Glu Glu Cys Lys Pro Cys Leu 
        115                 120                 125             


Lys Gln Xaa Cys Met Lys Phe Tyr Ala Arg Val Cys Arg Ser Gly Ser 
    130                 135                 140                 


Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu Asn Gln Ser Ser Pro 
145                 150                 155                 160 


Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp Ser Leu Leu Glu Asn 
                165                 170                 175     


Asp Arg Gln Gln Xaa His Met Leu Asp Val Met Gln Asp His Phe Ser 
            180                 185                 190         


Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln Asp Arg Phe Phe Xaa 
        195                 200                 205             


Arg Glu Pro Gln Asp Xaa Tyr His Tyr Leu Pro Phe Ser Leu Pro His 
    210                 215                 220                 


Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg Ile Val Arg Ser Leu 
225                 230                 235                 240 


Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe His Ala Met Phe Gln 
                245                 250                 255     


Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln Ala Met Asp Ile His 
            260                 265                 270         


Phe His Ser Pro Ala Phe Gln His Pro Pro Xaa Glu Phe Ile Arg Glu 
        275                 280                 285             


Gly Asp Asp Asp Arg Xaa Val Cys Arg 
    290                 295         


<210> 6426
<211> 32
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<400> 6426
Met Met Lys Xaa Leu Leu Leu Phe Val Gly Leu Leu Leu Xaa Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Xaa Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


<210> 6427
<211> 82
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<400> 6427
Met Met Lys Xaa Leu Leu Leu Phe Val Gly Leu Leu Leu Xaa Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Xaa Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Xaa Leu Ile Glu Lys Xaa Asn 
    50                  55                  60                  


Glu Glu Arg Lys Xaa Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu 
        


<210> 6428
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<400> 6428
Met Met Lys Xaa Leu Leu Leu Phe Val Gly Leu Leu Leu Xaa Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Xaa Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Xaa Leu Ile Glu Lys Xaa Asn 
    50                  55                  60                  


Glu Glu Arg Lys Xaa Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Xaa Arg Glu Ser Glu Xaa Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Xaa Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Xaa Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys 
    


<210> 6429
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<400> 6429
Met Met Lys Xaa Leu Leu Leu Phe Val Gly Leu Leu Leu Xaa Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Xaa Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Xaa Leu Ile Glu Lys Xaa Asn 
    50                  55                  60                  


Glu Glu Arg Lys Xaa Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Xaa Arg Glu Ser Glu Xaa Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Xaa Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Xaa Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val 
    130                 135     


<210> 6430
<211> 139
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<400> 6430
Met Met Lys Xaa Leu Leu Leu Phe Val Gly Leu Leu Leu Xaa Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Xaa Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Xaa Leu Ile Glu Lys Xaa Asn 
    50                  55                  60                  


Glu Glu Arg Lys Xaa Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Xaa Arg Glu Ser Glu Xaa Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Xaa Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Xaa Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln 
    130                 135                 


<210> 6431
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<400> 6431
Met Met Lys Xaa Leu Leu Leu Phe Val Gly Leu Leu Leu Xaa Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Xaa Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Xaa Leu Ile Glu Lys Xaa Asn 
    50                  55                  60                  


Glu Glu Arg Lys Xaa Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Xaa Arg Glu Ser Glu Xaa Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Xaa Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Xaa Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Xaa His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Arg Phe Phe Xaa Arg Glu Pro Gln Asp Xaa Tyr 
        195                 200                 


<210> 6432
<211> 449
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<400> 6432
Met Met Lys Xaa Leu Leu Leu Phe Val Gly Leu Leu Leu Xaa Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Xaa Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Xaa Leu Ile Glu Lys Xaa Asn 
    50                  55                  60                  


Glu Glu Arg Lys Xaa Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Xaa Arg Glu Ser Glu Xaa Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Xaa Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Xaa Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Xaa His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Arg Phe Phe Xaa Arg Glu Pro Gln Asp Xaa Tyr His Tyr Leu Pro 
        195                 200                 205             


Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg 
    210                 215                 220                 


Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe 
225                 230                 235                 240 


His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln 
                245                 250                 255     


Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Xaa 
            260                 265                 270         


Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Xaa Val Cys Arg Glu Ile 
        275                 280                 285             


Arg His Asn Ser Xaa Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys 
    290                 295                 300                 


Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Xaa Asn Asn Pro Ser Gln 
305                 310                 315                 320 


Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg 
                325                 330                 335     


Leu Xaa Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met 
            340                 345                 350         


Leu Asn Xaa Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp 
        355                 360                 365             


Val Ser Arg Leu Ala Asn Leu Xaa Gln Gly Glu Asp Gln Tyr Tyr Leu 
    370                 375                 380                 


Arg Val Xaa Xaa Val Ala Ser His Xaa Ser Asp Ser Asp Val Pro Ser 
385                 390                 395                 400 


Gly Val Xaa Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Xaa 
                405                 410                 415     


Val Xaa Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu 
            420                 425                 430         


Xaa Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu 
        435                 440                 445             


Glu 
    


<210> 6433
<211> 271
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<400> 6433
Met Met Lys Xaa Leu Leu Leu Phe Val Gly Leu Leu Leu Xaa Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Xaa Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Xaa Leu Ile Glu Lys Xaa Asn 
    50                  55                  60                  


Glu Glu Arg Lys Xaa Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Xaa Arg Glu Ser Glu Xaa Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Xaa Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Xaa Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Xaa His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe His Ala 
        195                 200                 205             


Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln Ala Met 
    210                 215                 220                 


Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Xaa Glu Phe 
225                 230                 235                 240 


Ile Arg Glu Gly Asp Asp Asp Arg Xaa Val Cys Arg Glu Ile Arg His 
                245                 250                 255     


Asn Ser Xaa Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys Cys 
            260                 265                 270     


<210> 6434
<211> 140
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<400> 6434
Xaa Ala Asp Cys Ser Xaa Asn Asn Pro Ser Gln Ala Lys Leu Arg Arg 
1               5                   10                  15      


Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg Leu Xaa Arg Lys Tyr 
            20                  25                  30          


Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met Leu Asn Xaa Ser Ser 
        35                  40                  45              


Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp Val Ser Arg Leu Ala 
    50                  55                  60                  


Asn Leu Xaa Gln Gly Glu Asp Gln Tyr Tyr Leu Arg Val Xaa Xaa Val 
65                  70                  75                  80  


Ala Ser His Xaa Ser Asp Ser Asp Val Pro Ser Gly Val Xaa Glu Val 
                85                  90                  95      


Val Val Lys Leu Phe Asp Ser Asp Pro Ile Xaa Val Xaa Val Pro Val 
            100                 105                 110         


Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu Xaa Val Ala Glu Lys 
        115                 120                 125             


Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu Glu 
    130                 135                 140 


<210> 6435
<211> 284
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<400> 6435
Xaa Gln Leu Glu Glu Phe Leu Asn Gln Ser Ser Pro Phe Tyr Phe Trp 
1               5                   10                  15      


Met Asn Gly Asp Arg Ile Asp Ser Leu Leu Glu Asn Asp Arg Gln Gln 
            20                  25                  30          


Xaa His Met Leu Asp Val Met Gln Asp His Phe Ser Arg Ala Ser Ser 
        35                  40                  45              


Ile Ile Asp Glu Leu Phe Gln Asp Arg Phe Phe Xaa Arg Glu Pro Gln 
    50                  55                  60                  


Asp Xaa Tyr His Tyr Leu Pro Phe Ser Leu Pro His Arg Arg Pro His 
65                  70                  75                  80  


Phe Phe Phe Pro Lys Ser Arg Ile Val Arg Ser Leu Met Pro Phe Ser 
                85                  90                  95      


Pro Tyr Glu Pro Leu Asn Phe His Ala Met Phe Gln Pro Phe Leu Glu 
            100                 105                 110         


Met Ile His Glu Ala Gln Gln Ala Met Asp Ile His Phe His Ser Pro 
        115                 120                 125             


Ala Phe Gln His Pro Pro Xaa Glu Phe Ile Arg Glu Gly Asp Asp Asp 
    130                 135                 140                 


Arg Xaa Val Cys Arg Glu Ile Arg His Asn Ser Xaa Gly Cys Leu Arg 
145                 150                 155                 160 


Met Lys Asp Gln Cys Asp Lys Cys Arg Glu Ile Leu Ser Val Asp Cys 
                165                 170                 175     


Ser Xaa Asn Asn Pro Ser Gln Ala Lys Leu Arg Arg Glu Leu Asp Glu 
            180                 185                 190         


Ser Leu Gln Val Ala Glu Arg Leu Xaa Arg Lys Tyr Asn Glu Leu Leu 
        195                 200                 205             


Lys Ser Tyr Gln Trp Lys Met Leu Asn Xaa Ser Ser Leu Leu Glu Gln 
    210                 215                 220                 


Leu Asn Glu Gln Phe Asn Trp Val Ser Arg Leu Ala Asn Leu Xaa Gln 
225                 230                 235                 240 


Gly Glu Asp Gln Tyr Tyr Leu Arg Val Xaa Xaa Val Ala Ser His Xaa 
                245                 250                 255     


Ser Asp Ser Asp Val Pro Ser Gly Val Xaa Glu Val Val Val Lys Leu 
            260                 265                 270         


Phe Asp Ser Asp Pro Ile Xaa Val Xaa Val Pro Val 
        275                 280                 


<210> 6436
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<400> 6436
Met Met Arg Ala Leu Gly Tyr Pro Arg His Ile Ser Met Glu Asn Phe 
1               5                   10                  15      


Arg Xaa Pro Asn Phe Gly Leu Val Ser Glu Val Leu Leu Trp Leu Val 
            20                  25                  30          


Lys Arg Tyr Glu Pro Gln Xaa Asp Ile Pro Pro Asp Val Asp Xaa Glu 
        35                  40                  45              


Gln Asp Arg Val Phe Phe Ile Lys Ala Ile Ala Gln Phe Met Ala Xaa 
    50                  55                  60                  


Lys Ala His Ile Lys Leu Asn Xaa Lys Lys Leu Tyr Gln Ala Asp Gly 
65                  70                  75                  80  


Tyr Ala Val Lys Glu Leu Leu Lys Ile Xaa Ser Val Leu Tyr Asn Ala 
                85                  90                  95      


Met Lys Xaa Lys Gly Met Glu Gly Ser Glu Ile Val Glu Glu Asp Val 
            100                 105                 110         


Asn Lys Phe Lys Phe Asp Leu Gly Ser 
        115                 120     


<210> 6437
<211> 151
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<400> 6437
Met Arg Xaa Glu Ala Ile Ala Arg Pro Leu Glu Ile Asn Glu Xaa Glu 
1               5                   10                  15      


Lys Val Met Arg Ile Ala Ile Lys Glu Ile Leu Xaa Gln Val Gln Lys 
            20                  25                  30          


Xaa Lys Asp Leu Leu Asn Asn Val Ala Ser Asp Glu Ala Asn Leu Glu 
        35                  40                  45              


Ala Lys Ile Glu Lys Arg Lys Leu Glu Leu Glu Arg Asn Arg Lys Arg 
    50                  55                  60                  


Leu Glu Xaa Leu Gln Ser Val Arg Pro Cys Phe Met Asp Glu Tyr Glu 
65                  70                  75                  80  


Lys Xaa Glu Glu Glu Leu Gln Lys Gln Tyr Asp Xaa Tyr Leu Glu Lys 
                85                  90                  95      


Phe Gln Asn Leu Xaa Tyr Leu Glu Gln Gln Leu Glu Asp His His Arg 
            100                 105                 110         


Met Glu Gln Glu Arg Phe Glu Glu Ala Lys Asn Xaa Leu Cys Leu Ile 
        115                 120                 125             


Gln Asn Lys Leu Lys Glu Glu Glu Lys Arg Leu Leu Lys Ser Gly Ser 
    130                 135                 140                 


Asn Asp Asp Ser Asp Ile Asp 
145                 150     


<210> 6438
<211> 247
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<400> 6438
Met Arg Xaa Glu Ala Ile Ala Arg Pro Leu Glu Ile Asn Glu Xaa Glu 
1               5                   10                  15      


Lys Val Met Arg Ile Ala Ile Lys Glu Ile Leu Xaa Gln Val Gln Lys 
            20                  25                  30          


Xaa Lys Asp Leu Leu Asn Asn Val Ala Ser Asp Glu Ala Asn Leu Glu 
        35                  40                  45              


Ala Lys Ile Glu Lys Arg Lys Leu Glu Leu Glu Arg Asn Arg Lys Arg 
    50                  55                  60                  


Leu Glu Xaa Leu Gln Ser Val Arg Pro Cys Phe Met Asp Glu Tyr Glu 
65                  70                  75                  80  


Lys Xaa Glu Glu Glu Leu Gln Lys Gln Tyr Asp Xaa Tyr Leu Glu Lys 
                85                  90                  95      


Phe Gln Asn Leu Xaa Tyr Leu Glu Gln Gln Leu Glu Asp His His Arg 
            100                 105                 110         


Met Glu Gln Glu Arg Phe Glu Glu Ala Lys Asn Xaa Leu Cys Leu Ile 
        115                 120                 125             


Gln Asn Lys Leu Lys Glu Glu Glu Lys Arg Leu Leu Lys Ser Gly Ser 
    130                 135                 140                 


Asn Asp Asp Ser Asp Ile Asp Ile Gln Glu Asp Asp Glu Ser Asp Ser 
145                 150                 155                 160 


Glu Leu Glu Glu Arg Arg Leu Pro Lys Pro Gln Xaa Ala Met Glu Met 
                165                 170                 175     


Leu Met Gln Gly Arg Pro Gly Lys Arg Ile Val Gly Xaa Met Gln Gly 
            180                 185                 190         


Gly Asp Ser Asp Asp Asn Glu Asp Ser Glu Glu Ser Glu Ile Asp Met 
        195                 200                 205             


Glu Asp Asp Asp Asp Glu Asp Asp Asp Leu Glu Asp Glu Ser Ile Ser 
    210                 215                 220                 


Leu Ser Pro Xaa Lys Pro Asn Arg Arg Val Arg Lys Ser Glu Pro Leu 
225                 230                 235                 240 


Asp Glu Ser Asp Asn Asp Phe 
                245         


<210> 6439
<211> 50
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<400> 6439
Met Ser Phe Arg Asp Leu Arg Asn Phe Xaa Glu Met Met Arg Ala Leu 
1               5                   10                  15      


Gly Tyr Pro Arg His Ile Ser Met Glu Asn Phe Arg Xaa Pro Asn Phe 
            20                  25                  30          


Gly Leu Val Ser Glu Val Leu Leu Trp Leu Val Lys Arg Pro Pro Arg 
        35                  40                  45              


His Ile 
    50  


<210> 6440
<211> 387
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<400> 6440
Met Ser Phe Arg Asp Leu Arg Asn Phe Xaa Glu Met Met Arg Ala Leu 
1               5                   10                  15      


Gly Tyr Pro Arg His Ile Ser Met Glu Asn Phe Arg Xaa Pro Asn Phe 
            20                  25                  30          


Gly Leu Val Ser Glu Val Leu Leu Trp Leu Val Lys Arg Tyr Glu Pro 
        35                  40                  45              


Gln Xaa Asp Ile Pro Pro Asp Val Asp Xaa Glu Gln Asp Arg Val Phe 
    50                  55                  60                  


Phe Ile Lys Ala Ile Ala Gln Phe Met Ala Xaa Lys Ala His Ile Lys 
65                  70                  75                  80  


Leu Asn Xaa Lys Lys Leu Tyr Gln Ala Asp Gly Tyr Ala Val Lys Glu 
                85                  90                  95      


Leu Leu Lys Ile Xaa Ser Val Leu Tyr Asn Ala Met Lys Xaa Lys Gly 
            100                 105                 110         


Met Glu Gly Ser Glu Ile Val Glu Glu Asp Val Asn Lys Phe Lys Phe 
        115                 120                 125             


Asp Leu Gly Ser Lys Ile Ala Asp Leu Lys Ala Ala Arg Gln Leu Ala 
    130                 135                 140                 


Ser Glu Ile Xaa Ser Lys Gly Ala Ser Leu Tyr Asp Leu Leu Gly Met 
145                 150                 155                 160 


Glu Val Glu Leu Arg Glu Met Arg Xaa Glu Ala Ile Ala Arg Pro Leu 
                165                 170                 175     


Glu Ile Asn Glu Xaa Glu Lys Val Met Arg Ile Ala Ile Lys Glu Ile 
            180                 185                 190         


Leu Xaa Gln Val Gln Lys Xaa Lys Asp Leu Leu Asn Asn Val Ala Ser 
        195                 200                 205             


Asp Glu Ala Asn Leu Glu Ala Lys Ile Glu Lys Arg Lys Leu Glu Leu 
    210                 215                 220                 


Glu Arg Asn Arg Lys Arg Leu Glu Xaa Leu Gln Ser Val Arg Pro Cys 
225                 230                 235                 240 


Phe Met Asp Glu Tyr Glu Lys Xaa Glu Glu Glu Leu Gln Lys Gln Tyr 
                245                 250                 255     


Asp Xaa Tyr Leu Glu Lys Phe Gln Asn Leu Xaa Tyr Leu Glu Gln Gln 
            260                 265                 270         


Leu Glu Asp His His Arg Met Glu Gln Glu Arg Phe Glu Glu Ala Lys 
        275                 280                 285             


Asn Xaa Leu Cys Leu Ile Gln Asn Lys Leu Lys Glu Glu Glu Lys Arg 
    290                 295                 300                 


Leu Leu Lys Ser Gly Ser Asn Asp Asp Ser Asp Ile Asp Ile Gln Glu 
305                 310                 315                 320 


Asp Asp Glu Ser Asp Ser Glu Leu Glu Glu Arg Arg Leu Pro Lys Pro 
                325                 330                 335     


Gln Xaa Ala Met Glu Met Leu Met Gln Gly Arg Pro Gly Lys Arg Ile 
            340                 345                 350         


Val Gly Xaa Met Gln Gly Gly Asp Ser Asp Asp Asn Val Ser Pro Pro 
        355                 360                 365             


Leu Pro Ser Val Val Leu Cys Xaa Leu Gly Leu Ala Val Pro Ile Asp 
    370                 375                 380                 


Gly Ser Gly 
385         


<210> 6441
<211> 413
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<400> 6441
Met Ser Phe Arg Asp Leu Arg Asn Phe Xaa Glu Met Met Arg Ala Leu 
1               5                   10                  15      


Gly Tyr Pro Arg His Ile Ser Met Glu Asn Phe Arg Xaa Pro Asn Phe 
            20                  25                  30          


Gly Leu Val Ser Glu Val Leu Leu Trp Leu Val Lys Arg Tyr Glu Pro 
        35                  40                  45              


Gln Xaa Asp Ile Pro Pro Asp Val Asp Xaa Glu Gln Asp Arg Val Phe 
    50                  55                  60                  


Phe Ile Lys Ala Ile Ala Gln Phe Met Ala Xaa Lys Ala His Ile Lys 
65                  70                  75                  80  


Leu Asn Xaa Lys Lys Leu Tyr Gln Ala Asp Gly Tyr Ala Val Lys Glu 
                85                  90                  95      


Leu Leu Lys Ile Xaa Ser Val Leu Tyr Asn Ala Met Lys Xaa Lys Gly 
            100                 105                 110         


Met Glu Gly Ser Glu Ile Val Glu Glu Asp Val Asn Lys Phe Lys Phe 
        115                 120                 125             


Asp Leu Gly Ser Lys Ile Ala Asp Leu Lys Ala Ala Arg Gln Leu Ala 
    130                 135                 140                 


Ser Glu Ile Xaa Ser Lys Gly Ala Ser Leu Tyr Asp Leu Leu Gly Met 
145                 150                 155                 160 


Glu Val Glu Leu Arg Glu Met Arg Xaa Glu Ala Ile Ala Arg Pro Leu 
                165                 170                 175     


Glu Ile Asn Glu Xaa Glu Lys Val Met Arg Ile Ala Ile Lys Glu Ile 
            180                 185                 190         


Leu Xaa Gln Val Gln Lys Xaa Lys Asp Leu Leu Asn Asn Val Ala Ser 
        195                 200                 205             


Asp Glu Ala Asn Leu Glu Ala Lys Ile Glu Lys Arg Lys Leu Glu Leu 
    210                 215                 220                 


Glu Arg Asn Arg Lys Arg Leu Glu Xaa Leu Gln Ser Val Arg Pro Cys 
225                 230                 235                 240 


Phe Met Asp Glu Tyr Glu Lys Xaa Glu Glu Glu Leu Gln Lys Gln Tyr 
                245                 250                 255     


Asp Xaa Tyr Leu Glu Lys Phe Gln Asn Leu Xaa Tyr Leu Glu Gln Gln 
            260                 265                 270         


Leu Glu Asp His His Arg Met Glu Gln Glu Arg Phe Glu Glu Ala Lys 
        275                 280                 285             


Asn Xaa Leu Cys Leu Ile Gln Asn Lys Leu Lys Glu Glu Glu Lys Arg 
    290                 295                 300                 


Leu Leu Lys Ser Gly Ser Asn Asp Asp Ser Asp Ile Asp Ile Gln Glu 
305                 310                 315                 320 


Asp Asp Glu Ser Asp Ser Glu Leu Glu Glu Arg Arg Leu Pro Lys Pro 
                325                 330                 335     


Gln Xaa Ala Met Glu Met Leu Met Gln Gly Arg Pro Gly Lys Arg Ile 
            340                 345                 350         


Val Gly Xaa Met Gln Gly Gly Asp Ser Asp Asp Asn Glu Asp Ser Glu 
        355                 360                 365             


Glu Ser Glu Ile Asp Met Glu Asp Asp Asp Asp Glu Asp Asp Asp Leu 
    370                 375                 380                 


Glu Asp Glu Ser Ile Ser Leu Ser Pro Xaa Lys Pro Asn Arg Arg Val 
385                 390                 395                 400 


Arg Lys Ser Glu Pro Leu Asp Glu Ser Asp Asn Asp Phe 
                405                 410             


<210> 6442
<211> 432
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<400> 6442
Met Ser Phe Arg Asp Leu Arg Asn Phe Xaa Glu Met Met Arg Ala Leu 
1               5                   10                  15      


Gly Tyr Pro Arg His Ile Ser Met Glu Asn Phe Arg Xaa Pro Asn Phe 
            20                  25                  30          


Gly Leu Val Ser Glu Val Leu Leu Trp Leu Val Lys Arg Tyr Glu Pro 
        35                  40                  45              


Gln Xaa Asp Ile Pro Pro Asp Val Asp Xaa Glu Gln Asp Arg Val Phe 
    50                  55                  60                  


Phe Ile Lys Ala Ile Ala Gln Phe Met Ala Xaa Lys Ala His Ile Lys 
65                  70                  75                  80  


Leu Asn Xaa Lys Lys Leu Tyr Gln Ala Asp Gly Tyr Ala Val Lys Glu 
                85                  90                  95      


Leu Leu Lys Ile Xaa Ser Val Leu Tyr Asn Ala Met Lys Xaa Lys Gly 
            100                 105                 110         


Met Glu Gly Ser Glu Ile Val Glu Glu Asp Val Asn Lys Phe Lys Phe 
        115                 120                 125             


Asp Leu Gly Ser Lys Ile Ala Asp Leu Lys Ala Ala Arg Gln Leu Ala 
    130                 135                 140                 


Ser Glu Ile Xaa Ser Lys Gly Ala Ser Leu Tyr Asp Leu Leu Gly Met 
145                 150                 155                 160 


Glu Val Glu Leu Arg Glu Met Arg Xaa Glu Ala Ile Ala Arg Pro Leu 
                165                 170                 175     


Glu Ile Asn Glu Xaa Glu Lys Val Met Arg Ile Ala Ile Lys Glu Ile 
            180                 185                 190         


Leu Xaa Gln Val Gln Lys Xaa Lys Asp Leu Leu Asn Asn Val Ala Ser 
        195                 200                 205             


Asp Glu Ala Asn Leu Glu Ala Lys Ile Glu Lys Arg Lys Leu Glu Leu 
    210                 215                 220                 


Glu Arg Asn Arg Lys Arg Leu Glu Xaa Leu Gln Ser Val Arg Pro Cys 
225                 230                 235                 240 


Phe Met Asp Glu Tyr Glu Lys Xaa Glu Glu Glu Leu Gln Lys Gln Tyr 
                245                 250                 255     


Asp Xaa Tyr Leu Glu Lys Phe Gln Asn Leu Xaa Tyr Leu Glu Gln Gln 
            260                 265                 270         


Leu Glu Asp His His Arg Met Glu Gln Glu Arg Phe Glu Glu Ala Lys 
        275                 280                 285             


Asn Xaa Leu Cys Leu Ile Gln Asn Lys Leu Lys Glu Glu Glu Lys Arg 
    290                 295                 300                 


Leu Leu Lys Ser Gly Ser Asn Asp Asp Ser Asp Ile Asp Ile Gln Glu 
305                 310                 315                 320 


Asp Asp Glu Ser Asp Ser Glu Leu Glu Glu Arg Arg Leu Pro Lys Pro 
                325                 330                 335     


Gln Xaa Ala Met Glu Met Leu Met Gln Gly Arg Pro Gly Lys Arg Ile 
            340                 345                 350         


Val Gly Xaa Met Gln Gly Gly Asp Ser Asp Asp Asn Met Glu Ala Ala 
        355                 360                 365             


Pro Ala Leu Leu Gly Lys Cys Lys Xaa Ser Ser Ser Lys Lys Gln Glu 
    370                 375                 380                 


Asp Ser Glu Glu Ser Glu Ile Asp Met Glu Asp Asp Asp Asp Glu Asp 
385                 390                 395                 400 


Asp Asp Leu Glu Asp Glu Ser Ile Ser Leu Ser Pro Xaa Lys Pro Asn 
                405                 410                 415     


Arg Arg Val Arg Lys Ser Glu Pro Leu Asp Glu Ser Asp Asn Asp Phe 
            420                 425                 430         


<210> 6443
<211> 201
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<400> 6443
Met Ser Phe Arg Asp Leu Arg Asn Phe Xaa Glu Met Met Arg Ala Leu 
1               5                   10                  15      


Gly Tyr Pro Arg His Ile Ser Met Glu Asn Phe Arg Xaa Pro Asn Phe 
            20                  25                  30          


Gly Leu Val Ser Glu Val Leu Leu Trp Leu Val Lys Arg Tyr Glu Pro 
        35                  40                  45              


Gln Xaa Asp Ile Pro Pro Asp Val Asp Xaa Glu Gln Asp Arg Val Phe 
    50                  55                  60                  


Phe Ile Lys Ala Ile Ala Gln Phe Met Ile Ala Asp Leu Lys Ala Ala 
65                  70                  75                  80  


Arg Gln Leu Ala Ser Glu Ile Xaa Ser Lys Gly Ala Ser Leu Tyr Asp 
                85                  90                  95      


Leu Leu Gly Met Glu Val Glu Leu Arg Glu Met Arg Xaa Glu Ala Ile 
            100                 105                 110         


Ala Arg Pro Leu Glu Ile Asn Glu Xaa Glu Lys Val Met Arg Ile Ala 
        115                 120                 125             


Ile Lys Glu Ile Leu Xaa Gln Val Gln Lys Xaa Lys Asp Leu Leu Asn 
    130                 135                 140                 


Asn Val Ala Ser Asp Glu Ala Asn Leu Glu Ala Lys Ile Glu Lys Arg 
145                 150                 155                 160 


Lys Leu Glu Leu Glu Arg Asn Arg Lys Arg Leu Glu Xaa Leu Gln Ser 
                165                 170                 175     


Val Arg Pro Cys Phe Met Asp Glu Tyr Glu Lys Xaa Glu Glu Glu Leu 
            180                 185                 190         


Gln Lys Gln Tyr Asp Xaa Tyr Leu Glu 
        195                 200     


<210> 6444
<211> 35
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<400> 6444
Met Ser Phe Arg Asp Leu Arg Asn Met Ser Pro Arg Leu Xaa Ser Arg 
1               5                   10                  15      


Leu Xaa Trp Ile Leu Asn Arg Xaa Glu Phe Ser Ser Leu Arg Gln Leu 
            20                  25                  30          


Pro Ser Ser 
        35  


<210> 6445
<211> 41
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<400> 6445
Met Ser Phe Arg Asp Leu Arg Asn Met Ser Pro Arg Leu Xaa Ser Arg 
1               5                   10                  15      


Leu Xaa Trp Ile Leu Asn Arg Xaa Glu Phe Ser Ser Leu Arg Gln Leu 
            20                  25                  30          


Pro Ser Ser Trp Pro Pro Arg His Ile 
        35                  40      


<210> 6446
<211> 28
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<400> 6446
Xaa Asn Arg Lys Glu Lys Ile Arg Xaa Gly Lys Lys Ser Glu Ala Xaa 
1               5                   10                  15      


Arg Asp Ser Ala Glu Cys Gln Ala Met Phe Tyr Gly 
            20                  25              


<210> 6447
<211> 371
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<400> 6447
Met Glu Asp Glu Asp Tyr Asn Xaa Ser Ile Ser Tyr Gly Asp Glu Tyr 
1               5                   10                  15      


Pro Asp Tyr Leu Asp Ser Ile Val Val Leu Glu Asp Leu Ser Pro Leu 
            20                  25                  30          


Glu Ala Arg Val Xaa Arg Ile Phe Leu Val Val Val Tyr Ser Ile Val 
        35                  40                  45              


Cys Phe Leu Gly Ile Leu Gly Asn Gly Leu Val Ile Ile Ile Ala Xaa 
    50                  55                  60                  


Phe Lys Met Lys Lys Xaa Val Asn Met Val Trp Phe Leu Asn Leu Ala 
65                  70                  75                  80  


Val Ala Asp Phe Leu Phe Asn Val Phe Leu Pro Ile His Ile Xaa Tyr 
                85                  90                  95      


Ala Ala Met Asp Tyr His Trp Val Phe Gly Xaa Ala Met Cys Lys Ile 
            100                 105                 110         


Ser Asn Phe Leu Leu Ile His Asn Met Phe Xaa Ser Val Phe Leu Leu 
        115                 120                 125             


Xaa Ile Ile Ser Ser Asp Arg Cys Ile Ser Val Leu Leu Pro Val Trp 
    130                 135                 140                 


Ser Gln Asn His Arg Ser Val Arg Leu Ala Tyr Met Ala Cys Met Val 
145                 150                 155                 160 


Ile Trp Val Leu Ala Phe Phe Leu Ser Ser Pro Ser Leu Val Phe Arg 
                165                 170                 175     


Asp Xaa Ala Asn Leu His Gly Lys Ile Ser Cys Phe Asn Asn Phe Ser 
            180                 185                 190         


Leu Ser Xaa Pro Gly Ser Ser Ser Trp Pro Xaa His Ser Gln Met Asp 
        195                 200                 205             


Pro Val Gly Tyr Ser Arg His Met Val Val Xaa Val Xaa Arg Phe Leu 
    210                 215                 220                 


Cys Gly Phe Leu Val Pro Val Leu Ile Ile Xaa Ala Cys Tyr Leu Xaa 
225                 230                 235                 240 


Ile Val Cys Lys Leu Gln Arg Asn Arg Leu Ala Lys Xaa Lys Lys Pro 
                245                 250                 255     


Phe Lys Ile Ile Val Xaa Ile Ile Ile Xaa Phe Phe Leu Cys Trp Cys 
            260                 265                 270         


Pro Tyr His Xaa Leu Asn Leu Leu Glu Leu His His Xaa Ala Met Pro 
        275                 280                 285             


Gly Ser Val Phe Ser Leu Gly Leu Pro Leu Ala Xaa Ala Leu Ala Ile 
    290                 295                 300                 


Ala Asn Ser Cys Met Asn Pro Ile Leu Tyr Val Phe Met Gly Gln Asp 
305                 310                 315                 320 


Phe Lys Lys Phe Lys Val Ala Leu Phe Ser Arg Leu Val Asn Ala Leu 
                325                 330                 335     


Ser Glu Asp Xaa Gly His Ser Ser Tyr Pro Ser His Arg Ser Phe Xaa 
            340                 345                 350         


Lys Met Ser Ser Met Asn Glu Arg Xaa Ser Met Asn Glu Arg Glu Xaa 
        355                 360                 365             


Gly Met Leu 
    370     


<210> 6448
<211> 143
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<400> 6448
Met Arg Met Glu Asp Glu Asp Tyr Asn Xaa Ser Ile Ser Tyr Gly Asp 
1               5                   10                  15      


Glu Tyr Pro Asp Tyr Leu Asp Ser Ile Val Val Leu Glu Asp Leu Ser 
            20                  25                  30          


Pro Leu Glu Ala Arg Val Xaa Arg Ile Phe Leu Val Val Val Tyr Ser 
        35                  40                  45              


Ile Val Cys Phe Leu Gly Ile Leu Gly Asn Gly Leu Val Ile Ile Ile 
    50                  55                  60                  


Ala Xaa Phe Lys Met Lys Lys Xaa Val Asn Met Val Trp Phe Leu Asn 
65                  70                  75                  80  


Leu Ala Val Ala Asp Phe Leu Phe Asn Val Phe Leu Pro Ile His Ile 
                85                  90                  95      


Xaa Tyr Ala Ala Met Asp Tyr His Trp Val Phe Gly Xaa Ala Met Cys 
            100                 105                 110         


Lys Ile Ser Asn Phe Leu Leu Ile His Asn Met Phe Xaa Ser Val Phe 
        115                 120                 125             


Leu Leu Xaa Ile Ile Ser Ser Asp Arg Cys Ile Ser Val Leu Leu 
    130                 135                 140             


<210> 6449
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<400> 6449
Met Arg Met Glu Asp Glu Asp Tyr Asn Xaa Ser Ile Ser Tyr Gly Asp 
1               5                   10                  15      


Glu Tyr Pro Asp Tyr Leu Asp Ser Ile Val Val Leu Glu Asp Leu Ser 
            20                  25                  30          


Pro Leu Glu Ala Arg Val Xaa Arg Ile Phe Leu Val Val Val Tyr Ser 
        35                  40                  45              


Ile Val Cys Phe Leu Gly Ile Leu Gly Asn Gly Leu Val Ile Ile Ile 
    50                  55                  60                  


Ala Xaa Phe Lys Met Lys Lys Xaa Val Asn Met Val Trp Phe Leu Asn 
65                  70                  75                  80  


Leu Ala Val Ala Asp Phe Leu Phe Asn Val Phe Leu Pro Ile His Ile 
                85                  90                  95      


Xaa Tyr Ala Ala Met Asp Tyr His Trp Val Phe Gly Xaa Ala Met Cys 
            100                 105                 110         


Lys Ile Ser Asn Phe Leu Leu Ile His Asn Met Phe Xaa Ser Val Phe 
        115                 120                 125             


Leu Leu Xaa Ile Ile Ser Ser Asp Arg Cys Ile Ser Val Leu Leu Pro 
    130                 135                 140                 


Val Trp Ser 
145         


<210> 6450
<211> 373
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<400> 6450
Met Arg Met Glu Asp Glu Asp Tyr Asn Xaa Ser Ile Ser Tyr Gly Asp 
1               5                   10                  15      


Glu Tyr Pro Asp Tyr Leu Asp Ser Ile Val Val Leu Glu Asp Leu Ser 
            20                  25                  30          


Pro Leu Glu Ala Arg Val Xaa Arg Ile Phe Leu Val Val Val Tyr Ser 
        35                  40                  45              


Ile Val Cys Phe Leu Gly Ile Leu Gly Asn Gly Leu Val Ile Ile Ile 
    50                  55                  60                  


Ala Xaa Phe Lys Met Lys Lys Xaa Val Asn Met Val Trp Phe Leu Asn 
65                  70                  75                  80  


Leu Ala Val Ala Asp Phe Leu Phe Asn Val Phe Leu Pro Ile His Ile 
                85                  90                  95      


Xaa Tyr Ala Ala Met Asp Tyr His Trp Val Phe Gly Xaa Ala Met Cys 
            100                 105                 110         


Lys Ile Ser Asn Phe Leu Leu Ile His Asn Met Phe Xaa Ser Val Phe 
        115                 120                 125             


Leu Leu Xaa Ile Ile Ser Ser Asp Arg Cys Ile Ser Val Leu Leu Pro 
    130                 135                 140                 


Val Trp Ser Gln Asn His Arg Ser Val Arg Leu Ala Tyr Met Ala Cys 
145                 150                 155                 160 


Met Val Ile Trp Val Leu Ala Phe Phe Leu Ser Ser Pro Ser Leu Val 
                165                 170                 175     


Phe Arg Asp Xaa Ala Asn Leu His Gly Lys Ile Ser Cys Phe Asn Asn 
            180                 185                 190         


Phe Ser Leu Ser Xaa Pro Gly Ser Ser Ser Trp Pro Xaa His Ser Gln 
        195                 200                 205             


Met Asp Pro Val Gly Tyr Ser Arg His Met Val Val Xaa Val Xaa Arg 
    210                 215                 220                 


Phe Leu Cys Gly Phe Leu Val Pro Val Leu Ile Ile Xaa Ala Cys Tyr 
225                 230                 235                 240 


Leu Xaa Ile Val Cys Lys Leu Gln Arg Asn Arg Leu Ala Lys Xaa Lys 
                245                 250                 255     


Lys Pro Phe Lys Ile Ile Val Xaa Ile Ile Ile Xaa Phe Phe Leu Cys 
            260                 265                 270         


Trp Cys Pro Tyr His Xaa Leu Asn Leu Leu Glu Leu His His Xaa Ala 
        275                 280                 285             


Met Pro Gly Ser Val Phe Ser Leu Gly Leu Pro Leu Ala Xaa Ala Leu 
    290                 295                 300                 


Ala Ile Ala Asn Ser Cys Met Asn Pro Ile Leu Tyr Val Phe Met Gly 
305                 310                 315                 320 


Gln Asp Phe Lys Lys Phe Lys Val Ala Leu Phe Ser Arg Leu Val Asn 
                325                 330                 335     


Ala Leu Ser Glu Asp Xaa Gly His Ser Ser Tyr Pro Ser His Arg Ser 
            340                 345                 350         


Phe Xaa Lys Met Ser Ser Met Asn Glu Arg Xaa Ser Met Asn Glu Arg 
        355                 360                 365             


Glu Xaa Gly Met Leu 
    370             


<210> 6451
<211> 79
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 6451
Met Gln Leu Asn Asp Lys Trp Gln Gly Leu Cys Trp Pro Met Met Asp 
1               5                   10                  15      


Phe Leu Arg Cys Val Xaa Ala Ala Leu Ile Tyr Phe Ala Ile Ser Ile 
            20                  25                  30          


Xaa Ala Ile Ala Lys Tyr Ser Asp Gly Ala Ser Lys Ala Ala Gly Gly 
        35                  40                  45              


Ser Val Pro Asp Xaa Arg Ala Val Cys Pro Ser Arg Ser Glu Met Gly 
    50                  55                  60                  


Arg Glu Ala Gly Ala Ala Ala Ser Arg Ser Arg Glu Ser Ala Leu 
65                  70                  75                  


<210> 6452
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 6452
Met Gln Leu Asn Asp Lys Trp Gln Gly Leu Cys Trp Pro Met Met Asp 
1               5                   10                  15      


Phe Leu Arg Cys Val Xaa Ala Ala Leu Ile Tyr Phe Ala Ile Ser Ile 
            20                  25                  30          


Xaa Ala Ile Ala Lys Tyr Ser Asp Gly Ala Ser Lys Ala Ala Gly Val 
        35                  40                  45              


Phe Gly Phe Phe Ala Xaa Ile Val Phe Ala Xaa Asp Phe Tyr Leu Ile 
    50                  55                  60                  


Phe Asn Asp Val Ala Lys Phe Leu Lys Gln Gly Asp Ser Ala Asp Glu 
65                  70                  75                  80  


Xaa Xaa Ala His Lys Xaa Glu Ala Arg Cys Trp Gly His Gly Asp Leu 
                85                  90                  95      


<210> 6453
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 6453
Met Gln Leu Asn Asp Lys Trp Gln Gly Leu Cys Trp Pro Met Met Asp 
1               5                   10                  15      


Phe Leu Arg Cys Val Xaa Ala Ala Leu Ile Tyr Phe Ala Ile Ser Ile 
            20                  25                  30          


Xaa Ala Ile Ala Lys Tyr Ser Asp Gly Ala Ser Lys Ala Ala Gly Val 
        35                  40                  45              


Phe Gly Phe Phe Ala Xaa Ile Val Phe Ala Xaa Asp Phe Tyr Leu Ile 
    50                  55                  60                  


Phe Asn Asp Val Ala Lys Phe Leu Lys Gln Gly Asp Ser Ala Asp Glu 
65                  70                  75                  80  


Xaa Xaa Ala His Lys Xaa Glu Glu Glu Asn Ser Asp Ser Asp Ser Asp 
                85                  90                  95      


<210> 6454
<211> 59
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<400> 6454
Met Trp Pro Pro Asp Pro Asp Pro Asp Pro Asp Pro Glu Pro Ala Gly 
1               5                   10                  15      


Gly Ser Arg Pro Gly Pro Ala Val Pro Gly Leu Arg Ala Leu Leu Pro 
            20                  25                  30          


Ala Arg Ala Phe Leu Cys Ser Leu Lys Gly Pro Gly Gly Phe Val Cys 
        35                  40                  45              


Xaa Trp Cys Ser Cys Pro His Gln Pro Leu Trp 
    50                  55                  


<210> 6455
<211> 116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<400> 6455
Met Trp Pro Pro Asp Pro Asp Pro Asp Pro Asp Pro Glu Pro Ala Gly 
1               5                   10                  15      


Gly Ser Arg Pro Gly Pro Ala Val Pro Gly Leu Arg Ala Leu Leu Pro 
            20                  25                  30          


Ala Arg Ala Phe Leu Cys Ser Leu Lys Gly Arg Leu Leu Leu Ala Glu 
        35                  40                  45              


Ser Gly Leu Ser Phe Ile Xaa Phe Ile Cys Tyr Val Ala Ser Ser Ala 
    50                  55                  60                  


Ser Ala Phe Leu Xaa Ala Pro Leu Leu Glu Phe Leu Leu Ala Leu Tyr 
65                  70                  75                  80  


Phe Leu Phe Ala Asp Ala Met Gln Leu Asn Asp Lys Trp Gln Gly Leu 
                85                  90                  95      


Cys Trp Pro Met Met Asp Phe Leu Arg Cys Val Xaa Ala Ala Leu Ile 
            100                 105                 110         


Tyr Phe Ala Ile 
        115     


<210> 6456
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<400> 6456
Met Trp Pro Pro Asp Pro Asp Pro Asp Pro Asp Pro Glu Pro Ala Gly 
1               5                   10                  15      


Gly Ser Arg Pro Gly Pro Ala Val Pro Gly Leu Arg Ala Leu Leu Pro 
            20                  25                  30          


Ala Arg Ala Phe Leu Cys Ser Leu Lys Gly Arg Leu Leu Leu Ala Glu 
        35                  40                  45              


Ser Gly Leu Ser Phe Ile Xaa Phe Ile Cys Tyr Val Ala Ser Ser Ala 
    50                  55                  60                  


Ser Ala Phe Leu Xaa Ala Pro Leu Leu Glu Phe Leu Leu Ala Leu Tyr 
65                  70                  75                  80  


Phe Leu Phe Ala Asp Ala Met Gln Leu Asn Asp Lys Trp Gln Gly Leu 
                85                  90                  95      


Cys Trp Pro Met Met Asp Phe Leu Arg Cys Val Xaa Ala Ala Leu Ile 
            100                 105                 110         


Tyr Phe Ala Ile Ser Ile Xaa Ala Ile Ala 
        115                 120         


<210> 6457
<211> 165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<400> 6457
Met Trp Pro Pro Asp Pro Asp Pro Asp Pro Asp Pro Glu Pro Ala Gly 
1               5                   10                  15      


Gly Ser Arg Pro Gly Pro Ala Val Pro Gly Leu Arg Ala Leu Leu Pro 
            20                  25                  30          


Ala Arg Ala Phe Leu Cys Ser Leu Lys Gly Arg Leu Leu Leu Ala Glu 
        35                  40                  45              


Ser Gly Leu Ser Phe Ile Xaa Phe Ile Cys Tyr Val Ala Ser Ser Ala 
    50                  55                  60                  


Ser Ala Phe Leu Xaa Ala Pro Leu Leu Glu Phe Leu Leu Ala Leu Tyr 
65                  70                  75                  80  


Phe Leu Phe Ala Asp Ala Met Gln Leu Asn Asp Lys Trp Gln Gly Leu 
                85                  90                  95      


Cys Trp Pro Met Met Asp Phe Leu Arg Cys Val Xaa Ala Ala Leu Ile 
            100                 105                 110         


Tyr Phe Ala Ile Ser Ile Xaa Ala Ile Ala Lys Tyr Ser Asp Gly Ala 
        115                 120                 125             


Ser Lys Ala Ala Gly Gly Ser Val Pro Asp Xaa Arg Ala Val Cys Pro 
    130                 135                 140                 


Ser Arg Ser Glu Met Gly Arg Glu Ala Gly Ala Ala Ala Ser Arg Ser 
145                 150                 155                 160 


Arg Glu Ser Ala Leu 
                165 


<210> 6458
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<400> 6458
Met Trp Pro Pro Asp Pro Asp Pro Asp Pro Asp Pro Glu Pro Ala Gly 
1               5                   10                  15      


Gly Ser Arg Pro Gly Pro Ala Val Pro Gly Leu Arg Ala Leu Leu Pro 
            20                  25                  30          


Ala Arg Ala Phe Leu Cys Ser Leu Lys Gly Arg Leu Leu Leu Ala Glu 
        35                  40                  45              


Ser Gly Leu Ser Phe Ile Xaa Phe Ile Cys Tyr Val Ala Ser Ser Ala 
    50                  55                  60                  


Ser Ala Phe Leu Xaa Ala Pro Leu Leu Glu Phe Leu Leu Ala Leu Tyr 
65                  70                  75                  80  


Phe Leu Phe Ala Asp Ala Met Gln Leu Asn Asp Lys Trp Gln Gly Leu 
                85                  90                  95      


Cys Trp Pro Met Met Asp Phe Leu Arg Cys Val Xaa Ala Ala Leu Ile 
            100                 105                 110         


Tyr Phe Ala Ile Ser Ile Xaa Ala Ile Ala Lys Tyr Ser Asp Gly Ala 
        115                 120                 125             


Ser Lys Ala Ala Gly Val Phe Gly Phe Phe Ala Xaa Ile Val Phe Ala 
    130                 135                 140                 


Xaa Asp Phe Tyr Leu Ile Phe Asn Asp Val Ala Lys Phe Leu Lys Gln 
145                 150                 155                 160 


Gly Asp Ser Ala Asp Glu Xaa Xaa Ala His Lys Xaa Glu Glu Glu Asn 
                165                 170                 175     


Ser Asp Ser Asp Ser Asp 
            180         


<210> 6459
<211> 150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<400> 6459
Met Trp Pro Pro Asp Pro Asp Pro Asp Pro Asp Pro Glu Pro Ala Gly 
1               5                   10                  15      


Gly Ser Arg Pro Gly Pro Ala Val Pro Gly Leu Arg Ala Leu Leu Pro 
            20                  25                  30          


Ala Arg Ala Phe Leu Cys Ser Leu Lys Gly Arg Leu Leu Leu Ala Glu 
        35                  40                  45              


Ser Gly Leu Ser Phe Ile Xaa Phe Ile Cys Tyr Val Ala Ser Ser Ala 
    50                  55                  60                  


Ser Ala Phe Leu Xaa Ala Pro Leu Leu Glu Phe Leu Leu Ala Leu Tyr 
65                  70                  75                  80  


Phe Leu Phe Ala Asp Ala Met Gln Leu Asn Asp Lys Trp Gln Gly Leu 
                85                  90                  95      


Cys Trp Pro Met Met Val Phe Gly Phe Phe Ala Xaa Ile Val Phe Ala 
            100                 105                 110         


Xaa Asp Phe Tyr Leu Ile Phe Asn Asp Val Ala Lys Phe Leu Lys Gln 
        115                 120                 125             


Gly Asp Ser Ala Asp Glu Xaa Xaa Ala His Lys Xaa Glu Glu Glu Asn 
    130                 135                 140                 


Ser Asp Ser Asp Ser Asp 
145                 150 


<210> 6460
<211> 160
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<400> 6460
Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
1               5                   10                  15      


Arg Glu Cys Pro Xaa Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
            20                  25                  30          


Gly Arg Asp Ile Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala Lys 
        35                  40                  45              


Asp Cys Asp Leu Gln Glu Asp Ala Cys Tyr Asn Cys Gly Arg Gly Gly 
    50                  55                  60                  


His Ile Ala Lys Asp Cys Lys Glu Pro Lys Arg Glu Arg Glu Gln Cys 
65                  70                  75                  80  


Cys Tyr Asn Cys Gly Lys Pro Gly His Leu Ala Arg Asp Cys Asp His 
                85                  90                  95      


Ala Asp Glu Gln Lys Cys Tyr Ser Cys Gly Glu Phe Gly His Ile Gln 
            100                 105                 110         


Lys Asp Cys Xaa Lys Val Lys Cys Tyr Arg Cys Gly Glu Xaa Gly His 
        115                 120                 125             


Val Ala Ile Asn Cys Ser Lys Xaa Ser Glu Val Asn Cys Tyr Arg Cys 
    130                 135                 140                 


Gly Glu Ser Gly His Leu Ala Arg Glu Cys Xaa Ile Glu Ala Xaa Ala 
145                 150                 155                 160 


<210> 6461
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 6461
Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
1               5                   10                  15      


Arg Glu Cys Pro Xaa Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
            20                  25                  30          


Gly Arg Gly Phe Gln Phe Val Ser Ser Ser Leu Pro Asp Ile Cys Tyr 
        35                  40                  45              


Arg Cys Gly Glu Ser Gly His Leu Ala Lys Asp Cys Asp Leu Gln Glu 
    50                  55                  60                  


Asp Ala Cys Tyr Asn Cys Gly Arg Gly Gly His Ile Ala Lys Asp Cys 
65                  70                  75                  80  


Lys Glu Pro Lys Arg Glu Arg Glu Gln Cys Cys Tyr Asn Cys Gly Lys 
                85                  90                  95      


Pro Gly His Leu Ala Arg Asp Cys Asp His Ala Asp Glu Gln Lys Cys 
            100                 105                 110         


Tyr Ser Cys Gly Glu Phe Gly His Ile Gln Lys Asp Cys Xaa Lys Val 
        115                 120                 125             


Lys Cys Tyr Arg Cys Gly Glu Xaa Gly His Val Ala Ile Asn Cys Ser 
    130                 135                 140                 


Lys Xaa Ser Glu Val Asn Cys Tyr Arg Cys Gly Glu Ser Gly His Leu 
145                 150                 155                 160 


Ala Arg Glu Cys Xaa Ile Glu Ala Xaa Ala 
                165                 170 


<210> 6462
<211> 172
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<400> 6462
Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
1               5                   10                  15      


Arg Glu Cys Pro Xaa Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
            20                  25                  30          


Gly Arg Gly Phe Gln Phe Val Ser Ser Ser Leu Pro Asp Ile Cys Tyr 
        35                  40                  45              


Arg Cys Gly Glu Ser Gly His Leu Ala Lys Asp Cys Asp Leu Gln Glu 
    50                  55                  60                  


Asp Val Glu Ala Cys Tyr Asn Cys Gly Arg Gly Gly His Ile Ala Lys 
65                  70                  75                  80  


Asp Cys Lys Glu Pro Lys Arg Glu Arg Glu Gln Cys Cys Tyr Asn Cys 
                85                  90                  95      


Gly Lys Pro Gly His Leu Ala Arg Asp Cys Asp His Ala Asp Glu Gln 
            100                 105                 110         


Lys Cys Tyr Ser Cys Gly Glu Phe Gly His Ile Gln Lys Asp Cys Xaa 
        115                 120                 125             


Lys Val Lys Cys Tyr Arg Cys Gly Glu Xaa Gly His Val Ala Ile Asn 
    130                 135                 140                 


Cys Ser Lys Xaa Ser Glu Val Asn Cys Tyr Arg Cys Gly Glu Ser Gly 
145                 150                 155                 160 


His Leu Ala Arg Glu Cys Xaa Ile Glu Ala Xaa Ala 
                165                 170         


<210> 6463
<211> 114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(105)
<223> Selenocysteine

<400> 6463
Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
1               5                   10                  15      


Arg Glu Cys Pro Xaa Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
            20                  25                  30          


Gly Arg Gly Gly Phe Gln Phe Val Ser Ser Ser Leu Pro Asp Ile Cys 
        35                  40                  45              


Tyr Arg Cys Gly Glu Ser Gly His Leu Ala Lys Asp Cys Asp Leu Gln 
    50                  55                  60                  


Glu Asp Val Leu Ala Cys Phe Phe Ser Leu Leu Leu Lys Pro Ala Ile 
65                  70                  75                  80  


Xaa Ala Val Glu Val Ala Xaa Leu Pro Arg Xaa Ala Arg Ser Pro Arg 
                85                  90                  95      


Glu Ser Glu Ser Asn Ala Ala Xaa Xaa Val Ala Asn Gln Ala Ile Trp 
            100                 105                 110         


Leu Val 
        


<210> 6464
<211> 167
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 6464
Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
1               5                   10                  15      


Arg Glu Cys Pro Xaa Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
            20                  25                  30          


Gly Arg Gly Gly Phe Xaa Ser Asp Arg Asp Ile Cys Tyr Arg Cys Gly 
        35                  40                  45              


Glu Ser Gly His Leu Ala Lys Asp Cys Asp Leu Gln Glu Asp Ala Cys 
    50                  55                  60                  


Tyr Asn Cys Gly Arg Gly Gly His Ile Ala Lys Asp Cys Lys Glu Pro 
65                  70                  75                  80  


Lys Arg Glu Arg Glu Gln Cys Cys Tyr Asn Cys Gly Lys Pro Gly His 
                85                  90                  95      


Leu Ala Arg Asp Cys Asp His Ala Asp Glu Gln Lys Cys Tyr Ser Cys 
            100                 105                 110         


Gly Glu Phe Gly His Ile Gln Lys Asp Cys Xaa Lys Val Lys Cys Tyr 
        115                 120                 125             


Arg Cys Gly Glu Xaa Gly His Val Ala Ile Asn Cys Ser Lys Xaa Ser 
    130                 135                 140                 


Glu Val Asn Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala Arg Glu 
145                 150                 155                 160 


Cys Xaa Ile Glu Ala Xaa Ala 
                165         


<210> 6465
<211> 177
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<400> 6465
Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
1               5                   10                  15      


Arg Glu Cys Pro Xaa Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
            20                  25                  30          


Gly Arg Gly Gly Phe Xaa Ser Asp Arg Gly Phe Gln Phe Val Ser Ser 
        35                  40                  45              


Ser Leu Pro Asp Ile Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala 
    50                  55                  60                  


Lys Asp Cys Asp Leu Gln Glu Asp Ala Cys Tyr Asn Cys Gly Arg Gly 
65                  70                  75                  80  


Gly His Ile Ala Lys Asp Cys Lys Glu Pro Lys Arg Glu Arg Glu Gln 
                85                  90                  95      


Cys Cys Tyr Asn Cys Gly Lys Pro Gly His Leu Ala Arg Asp Cys Asp 
            100                 105                 110         


His Ala Asp Glu Gln Lys Cys Tyr Ser Cys Gly Glu Phe Gly His Ile 
        115                 120                 125             


Gln Lys Asp Cys Xaa Lys Val Lys Cys Tyr Arg Cys Gly Glu Xaa Gly 
    130                 135                 140                 


His Val Ala Ile Asn Cys Ser Lys Xaa Ser Glu Val Asn Cys Tyr Arg 
145                 150                 155                 160 


Cys Gly Glu Ser Gly His Leu Ala Arg Glu Cys Xaa Ile Glu Ala Xaa 
                165                 170                 175     


Ala 
    


<210> 6466
<211> 178
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<400> 6466
Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
1               5                   10                  15      


Arg Glu Cys Pro Xaa Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
            20                  25                  30          


Gly Arg Gly Gly Phe Xaa Ser Asp Arg Gly Phe Gln Phe Val Ser Ser 
        35                  40                  45              


Ser Leu Pro Asp Ile Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala 
    50                  55                  60                  


Lys Asp Cys Asp Leu Gln Glu Asp Glu Ala Cys Tyr Asn Cys Gly Arg 
65                  70                  75                  80  


Gly Gly His Ile Ala Lys Asp Cys Lys Glu Pro Lys Arg Glu Arg Glu 
                85                  90                  95      


Gln Cys Cys Tyr Asn Cys Gly Lys Pro Gly His Leu Ala Arg Asp Cys 
            100                 105                 110         


Asp His Ala Asp Glu Gln Lys Cys Tyr Ser Cys Gly Glu Phe Gly His 
        115                 120                 125             


Ile Gln Lys Asp Cys Xaa Lys Val Lys Cys Tyr Arg Cys Gly Glu Xaa 
    130                 135                 140                 


Gly His Val Ala Ile Asn Cys Ser Lys Xaa Ser Glu Val Asn Cys Tyr 
145                 150                 155                 160 


Arg Cys Gly Glu Ser Gly His Leu Ala Arg Glu Cys Xaa Ile Glu Ala 
                165                 170                 175     


Xaa Ala 
        


<210> 6467
<211> 179
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<400> 6467
Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
1               5                   10                  15      


Arg Glu Cys Pro Xaa Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
            20                  25                  30          


Gly Arg Gly Gly Phe Xaa Ser Asp Arg Gly Phe Gln Phe Val Ser Ser 
        35                  40                  45              


Ser Leu Pro Asp Ile Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala 
    50                  55                  60                  


Lys Asp Cys Asp Leu Gln Glu Asp Val Glu Ala Cys Tyr Asn Cys Gly 
65                  70                  75                  80  


Arg Gly Gly His Ile Ala Lys Asp Cys Lys Glu Pro Lys Arg Glu Arg 
                85                  90                  95      


Glu Gln Cys Cys Tyr Asn Cys Gly Lys Pro Gly His Leu Ala Arg Asp 
            100                 105                 110         


Cys Asp His Ala Asp Glu Gln Lys Cys Tyr Ser Cys Gly Glu Phe Gly 
        115                 120                 125             


His Ile Gln Lys Asp Cys Xaa Lys Val Lys Cys Tyr Arg Cys Gly Glu 
    130                 135                 140                 


Xaa Gly His Val Ala Ile Asn Cys Ser Lys Xaa Ser Glu Val Asn Cys 
145                 150                 155                 160 


Tyr Arg Cys Gly Glu Ser Gly His Leu Ala Arg Glu Cys Xaa Ile Glu 
                165                 170                 175     


Ala Xaa Ala 
            


<210> 6468
<211> 759
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<400> 6468
Met Glu Ser Arg Ser Ser Pro Arg Leu Glu Cys Ser Gly Ala Ile Ser 
1               5                   10                  15      


Ala His Cys Ser Leu His Leu Pro Asp Ser Ser Asp Phe Gln Leu Ile 
            20                  25                  30          


Phe Val Phe Leu Val Glu Met Gly Phe His His Val Gly Gln Ala Gly 
        35                  40                  45              


Leu Glu Leu Leu Ile Ser Ser Asp Leu Pro Xaa Ser Ala Ser Gln Ser 
    50                  55                  60                  


Ala Gly Ile Xaa Asp Met Lys Leu Ser Met Lys Asn Asn Ile Ile Asn 
65                  70                  75                  80  


Xaa Gln Gln Ser Phe Val Xaa Met Pro Asn Val Ile Val Pro Asp Ile 
                85                  90                  95      


Glu Lys Glu Ile Arg Arg Met Glu Asn Gly Ala Cys Ser Ser Phe Ser 
            100                 105                 110         


Glu Asp Asp Asp Ser Ala Ser Xaa Ser Glu Glu Ser Glu Asn Glu Asn 
        115                 120                 125             


Pro His Ala Arg Gly Ser Phe Ser Tyr Lys Ser Leu Arg Lys Gly Gly 
    130                 135                 140                 


Pro Ser Gln Arg Glu Gln Tyr Leu Pro Gly Ala Ile Ala Leu Phe Asn 
145                 150                 155                 160 


Val Asn Asn Ser Ser Asn Lys Asp Gln Glu Pro Glu Glu Lys Lys Lys 
                165                 170                 175     


Lys Lys Lys Glu Lys Lys Ser Lys Ser Asp Asp Lys Asn Glu Asn Lys 
            180                 185                 190         


Asn Asp Pro Glu Lys Lys Lys Lys Lys Lys Asp Lys Glu Lys Lys Lys 
        195                 200                 205             


Lys Glu Glu Lys Ser Lys Asp Lys Lys Glu Glu Glu Lys Lys Glu Val 
    210                 215                 220                 


Val Val Ile Asp Pro Ser Gly Asn Xaa Tyr Tyr Asn Trp Leu Phe Cys 
225                 230                 235                 240 


Ile Xaa Leu Pro Val Met Tyr Asn Trp Xaa Met Val Ile Ala Arg Ala 
                245                 250                 255     


Cys Phe Asp Glu Leu Gln Ser Asp Tyr Leu Glu Tyr Trp Leu Ile Leu 
            260                 265                 270         


Asp Tyr Val Ser Asp Ile Val Tyr Leu Ile Asp Met Phe Val Arg Xaa 
        275                 280                 285             


Arg Xaa Gly Tyr Leu Glu Gln Gly Leu Leu Val Lys Glu Glu Leu Lys 
    290                 295                 300                 


Leu Ile Asn Lys Tyr Lys Ser Asn Leu Gln Phe Lys Leu Asp Val Leu 
305                 310                 315                 320 


Ser Leu Ile Pro Xaa Asp Leu Leu Tyr Phe Lys Leu Gly Trp Asn Tyr 
                325                 330                 335     


Pro Glu Ile Arg Leu Asn Arg Leu Leu Arg Phe Ser Arg Met Phe Glu 
            340                 345                 350         


Phe Phe Gln Arg Xaa Glu Xaa Arg Xaa Asn Tyr Pro Asn Ile Phe Arg 
        355                 360                 365             


Ile Ser Asn Leu Val Met Tyr Ile Val Ile Ile Ile His Trp Asn Ala 
    370                 375                 380                 


Cys Val Phe Tyr Ser Ile Ser Lys Ala Ile Gly Phe Gly Asn Asp Xaa 
385                 390                 395                 400 


Trp Val Tyr Pro Asp Ile Asn Asp Pro Glu Phe Gly Arg Leu Ala Arg 
                405                 410                 415     


Lys Tyr Val Tyr Ser Leu Tyr Trp Ser Xaa Leu Xaa Leu Xaa Xaa Ile 
            420                 425                 430         


Gly Glu Xaa Pro Pro Pro Val Arg Asp Ser Glu Tyr Val Phe Val Val 
        435                 440                 445             


Val Asp Phe Leu Ile Gly Val Leu Ile Phe Ala Xaa Ile Val Gly Asn 
    450                 455                 460                 


Ile Gly Ser Met Ile Ser Asn Met Asn Ala Ala Arg Ala Glu Phe Gln 
465                 470                 475                 480 


Ala Arg Ile Asp Ala Ile Lys Gln Tyr Met His Phe Arg Asn Val Ser 
                485                 490                 495     


Lys Asp Met Glu Lys Arg Val Ile Lys Trp Phe Asp Tyr Leu Trp Xaa 
            500                 505                 510         


Asn Lys Lys Xaa Val Asp Glu Lys Glu Val Leu Lys Tyr Leu Pro Asp 
        515                 520                 525             


Lys Leu Arg Ala Glu Ile Ala Ile Asn Val His Leu Asp Xaa Leu Lys 
    530                 535                 540                 


Lys Val Arg Ile Phe Ala Asp Cys Glu Ala Gly Leu Leu Val Glu Leu 
545                 550                 555                 560 


Val Leu Lys Leu Gln Pro Gln Val Tyr Ser Pro Gly Asp Tyr Ile Cys 
                565                 570                 575     


Lys Lys Gly Asp Ile Gly Arg Glu Met Tyr Ile Ile Lys Glu Gly Lys 
            580                 585                 590         


Leu Ala Val Val Ala Asp Asp Gly Val Xaa Gln Phe Val Val Leu Ser 
        595                 600                 605             


Asp Gly Ser Tyr Phe Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly Ser 
    610                 615                 620                 


Lys Ala Gly Asn Arg Arg Xaa Ala Asn Ile Lys Ser Ile Gly Tyr Ser 
625                 630                 635                 640 


Asp Leu Phe Cys Leu Ser Lys Asp Asp Leu Met Glu Ala Leu Xaa Glu 
                645                 650                 655     


Tyr Pro Asp Ala Lys Xaa Met Leu Glu Glu Lys Gly Lys Gln Ile Leu 
            660                 665                 670         


Met Lys Asp Gly Leu Leu Asp Leu Asn Ile Ala Asn Ala Gly Ser Asp 
        675                 680                 685             


Pro Lys Asp Leu Glu Glu Lys Val Xaa Arg Met Glu Gly Ser Val Asp 
    690                 695                 700                 


Leu Leu Gln Xaa Arg Phe Ala Arg Ile Leu Ala Glu Tyr Glu Ser Met 
705                 710                 715                 720 


Gln Gln Lys Leu Lys Gln Arg Leu Xaa Lys Val Glu Lys Phe Leu Lys 
                725                 730                 735     


Pro Leu Ile Asp Xaa Glu Phe Ser Ser Ile Glu Gly Pro Gly Ala Glu 
            740                 745                 750         


Ser Gly Pro Ile Asp Ser Xaa 
        755                 


<210> 6469
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<400> 6469
Met Lys Leu Ser Met Lys Asn Asn Ile Ile Asn Xaa Gln Gln Ser Phe 
1               5                   10                  15      


Val Xaa Met Pro Asn Val Ile Val Pro Asp Ile Glu Lys Glu Ile Arg 
            20                  25                  30          


Arg Met Glu Asn Gly Ala Cys Ser Ser Phe Ser Glu Asp Asp Asp Ser 
        35                  40                  45              


Ala Ser Xaa Ser Glu Glu Ser Glu Asn Glu Asn Pro His Ala Arg Gly 
    50                  55                  60                  


Ser Phe Ser Tyr Lys Ser Leu Arg Lys Gly Gly Pro Ser Gln Arg Glu 
65                  70                  75                  80  


Gln Tyr Leu Pro Gly Ala Ile Ala Leu Phe Asn Val Asn Asn Ser Ser 
                85                  90                  95      


Asn Lys Asp 
            


<210> 6470
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<400> 6470
Met Lys Leu Ser Met Lys Asn Asn Ile Ile Asn Xaa Gln Gln Ser Phe 
1               5                   10                  15      


Val Xaa Met Pro Asn Val Ile Val Pro Asp Ile Glu Lys Glu Ile Arg 
            20                  25                  30          


Arg Met Glu Asn Gly Ala Cys Ser Ser Phe Ser Glu Asp Asp Asp Ser 
        35                  40                  45              


Ala Ser Xaa Ser Glu Glu Ser Glu Asn Glu Asn Pro His Ala Arg Gly 
    50                  55                  60                  


Ser Phe Ser Tyr Lys Ser Leu Arg Lys Gly Gly Pro Ser Gln Arg Glu 
65                  70                  75                  80  


Gln Tyr Leu Pro Gly Ala Ile Ala Leu Phe Asn Val Asn Asn Ser Ser 
                85                  90                  95      


Asn Lys Asp Gln Glu Pro Glu Glu Lys Lys Lys Lys Lys Lys Glu Lys 
            100                 105                 110         


Lys Ser Lys Ser Asp Asp Lys Asn Glu Asn Lys Asn Asp Pro Glu Lys 
        115                 120                 125             


<210> 6471
<211> 690
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<400> 6471
Met Lys Leu Ser Met Lys Asn Asn Ile Ile Asn Xaa Gln Gln Ser Phe 
1               5                   10                  15      


Val Xaa Met Pro Asn Val Ile Val Pro Asp Ile Glu Lys Glu Ile Arg 
            20                  25                  30          


Arg Met Glu Asn Gly Ala Cys Ser Ser Phe Ser Glu Asp Asp Asp Ser 
        35                  40                  45              


Ala Ser Xaa Ser Glu Glu Ser Glu Asn Glu Asn Pro His Ala Arg Gly 
    50                  55                  60                  


Ser Phe Ser Tyr Lys Ser Leu Arg Lys Gly Gly Pro Ser Gln Arg Glu 
65                  70                  75                  80  


Gln Tyr Leu Pro Gly Ala Ile Ala Leu Phe Asn Val Asn Asn Ser Ser 
                85                  90                  95      


Asn Lys Asp Gln Glu Pro Glu Glu Lys Lys Lys Lys Lys Lys Glu Lys 
            100                 105                 110         


Lys Ser Lys Ser Asp Asp Lys Asn Glu Asn Lys Asn Asp Pro Glu Lys 
        115                 120                 125             


Lys Lys Lys Lys Lys Asp Lys Glu Lys Lys Lys Lys Glu Glu Lys Ser 
    130                 135                 140                 


Lys Asp Lys Lys Glu Glu Glu Lys Lys Glu Val Val Val Ile Asp Pro 
145                 150                 155                 160 


Ser Gly Asn Xaa Tyr Tyr Asn Trp Leu Phe Cys Ile Xaa Leu Pro Val 
                165                 170                 175     


Met Tyr Asn Trp Xaa Met Val Ile Ala Arg Ala Cys Phe Asp Glu Leu 
            180                 185                 190         


Gln Ser Asp Tyr Leu Glu Tyr Trp Leu Ile Leu Asp Tyr Val Ser Asp 
        195                 200                 205             


Ile Val Tyr Leu Ile Asp Met Phe Val Arg Xaa Arg Xaa Gly Tyr Leu 
    210                 215                 220                 


Glu Gln Gly Leu Leu Val Lys Glu Glu Leu Lys Leu Ile Asn Lys Tyr 
225                 230                 235                 240 


Lys Ser Asn Leu Gln Phe Lys Leu Asp Val Leu Ser Leu Ile Pro Xaa 
                245                 250                 255     


Asp Leu Leu Tyr Phe Lys Leu Gly Trp Asn Tyr Pro Glu Ile Arg Leu 
            260                 265                 270         


Asn Arg Leu Leu Arg Phe Ser Arg Met Phe Glu Phe Phe Gln Arg Xaa 
        275                 280                 285             


Glu Xaa Arg Xaa Asn Tyr Pro Asn Ile Phe Arg Ile Ser Asn Leu Val 
    290                 295                 300                 


Met Tyr Ile Val Ile Ile Ile His Trp Asn Ala Cys Val Phe Tyr Ser 
305                 310                 315                 320 


Ile Ser Lys Ala Ile Gly Phe Gly Asn Asp Xaa Trp Val Tyr Pro Asp 
                325                 330                 335     


Ile Asn Asp Pro Glu Phe Gly Arg Leu Ala Arg Lys Tyr Val Tyr Ser 
            340                 345                 350         


Leu Tyr Trp Ser Xaa Leu Xaa Leu Xaa Xaa Ile Gly Glu Xaa Pro Pro 
        355                 360                 365             


Pro Val Arg Asp Ser Glu Tyr Val Phe Val Val Val Asp Phe Leu Ile 
    370                 375                 380                 


Gly Val Leu Ile Phe Ala Xaa Ile Val Gly Asn Ile Gly Ser Met Ile 
385                 390                 395                 400 


Ser Asn Met Asn Ala Ala Arg Ala Glu Phe Gln Ala Arg Ile Asp Ala 
                405                 410                 415     


Ile Lys Gln Tyr Met His Phe Arg Asn Val Ser Lys Asp Met Glu Lys 
            420                 425                 430         


Arg Val Ile Lys Trp Phe Asp Tyr Leu Trp Xaa Asn Lys Lys Xaa Val 
        435                 440                 445             


Asp Glu Lys Glu Val Leu Lys Tyr Leu Pro Asp Lys Leu Arg Ala Glu 
    450                 455                 460                 


Ile Ala Ile Asn Val His Leu Asp Xaa Leu Lys Lys Val Arg Ile Phe 
465                 470                 475                 480 


Ala Asp Cys Glu Ala Gly Leu Leu Val Glu Leu Val Leu Lys Leu Gln 
                485                 490                 495     


Pro Gln Val Tyr Ser Pro Gly Asp Tyr Ile Cys Lys Lys Gly Asp Ile 
            500                 505                 510         


Gly Arg Glu Met Tyr Ile Ile Lys Glu Gly Lys Leu Ala Val Val Ala 
        515                 520                 525             


Asp Asp Gly Val Xaa Gln Phe Val Val Leu Ser Asp Gly Ser Tyr Phe 
    530                 535                 540                 


Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly Ser Lys Ala Gly Asn Arg 
545                 550                 555                 560 


Arg Xaa Ala Asn Ile Lys Ser Ile Gly Tyr Ser Asp Leu Phe Cys Leu 
                565                 570                 575     


Ser Lys Asp Asp Leu Met Glu Ala Leu Xaa Glu Tyr Pro Asp Ala Lys 
            580                 585                 590         


Xaa Met Leu Glu Glu Lys Gly Lys Gln Ile Leu Met Lys Asp Gly Leu 
        595                 600                 605             


Leu Asp Leu Asn Ile Ala Asn Ala Gly Ser Asp Pro Lys Asp Leu Glu 
    610                 615                 620                 


Glu Lys Val Xaa Arg Met Glu Gly Ser Val Asp Leu Leu Gln Xaa Arg 
625                 630                 635                 640 


Phe Ala Arg Ile Leu Ala Glu Tyr Glu Ser Met Gln Gln Lys Leu Lys 
                645                 650                 655     


Gln Arg Leu Xaa Lys Val Glu Lys Phe Leu Lys Pro Leu Ile Asp Xaa 
            660                 665                 670         


Glu Phe Ser Ser Ile Glu Gly Pro Gly Ala Glu Ser Gly Pro Ile Asp 
        675                 680                 685             


Ser Xaa 
    690 


<210> 6472
<211> 676
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<400> 6472
Met Ala Lys Ile Asn Xaa Gln Tyr Ser His Pro Ser Arg Xaa His Leu 
1               5                   10                  15      


Lys Val Lys Xaa Ser Asp Arg Asp Leu Asn Arg Ala Glu Asn Gly Leu 
            20                  25                  30          


Ser Arg Ala His Ser Ser Ser Glu Glu Xaa Ser Ser Val Leu Gln Pro 
        35                  40                  45              


Gly Ile Ala Met Glu Xaa Arg Gly Leu Ala Asp Ser Gly Gln Gly Ser 
    50                  55                  60                  


Phe Xaa Gly Gln Gly Ile Ala Arg Leu Ser Arg Leu Ile Phe Leu Leu 
65                  70                  75                  80  


Arg Arg Trp Ala Ala Arg His Val His His Gln Asp Gln Gly Pro Asp 
                85                  90                  95      


Ser Phe Pro Asp Arg Phe Arg Gly Ala Glu Leu Lys Glu Val Ser Ser 
            100                 105                 110         


Gln Glu Ser Asn Ala Gln Ala Asn Val Gly Ser Gln Glu Pro Ala Asp 
        115                 120                 125             


Arg Gly Arg Arg Lys Lys Xaa Lys Lys Lys Asp Ala Ile Val Val Asp 
    130                 135                 140                 


Pro Ser Ser Asn Leu Tyr Tyr Arg Trp Leu Xaa Ala Ile Ala Leu Pro 
145                 150                 155                 160 


Val Phe Tyr Asn Trp Tyr Leu Leu Ile Cys Arg Ala Cys Phe Asp Glu 
                165                 170                 175     


Leu Gln Ser Glu Tyr Leu Met Leu Trp Leu Val Leu Asp Tyr Ser Ala 
            180                 185                 190         


Asp Val Leu Tyr Val Leu Asp Val Leu Val Arg Ala Arg Xaa Gly Phe 
        195                 200                 205             


Leu Glu Gln Gly Leu Met Val Ser Asp Xaa Asn Arg Leu Trp Gln His 
    210                 215                 220                 


Tyr Lys Xaa Xaa Xaa Gln Phe Lys Leu Asp Val Leu Ser Leu Val Pro 
225                 230                 235                 240 


Xaa Asp Leu Ala Tyr Leu Lys Val Gly Xaa Asn Tyr Pro Glu Val Arg 
                245                 250                 255     


Phe Asn Arg Leu Leu Lys Phe Ser Arg Leu Phe Glu Phe Phe Asp Arg 
            260                 265                 270         


Xaa Glu Xaa Arg Xaa Asn Tyr Pro Asn Met Phe Arg Ile Gly Asn Leu 
        275                 280                 285             


Val Leu Tyr Ile Leu Ile Ile Ile His Trp Asn Ala Cys Ile Tyr Phe 
    290                 295                 300                 


Ala Ile Ser Lys Phe Ile Gly Phe Gly Xaa Asp Ser Trp Val Tyr Pro 
305                 310                 315                 320 


Asn Ile Ser Ile Pro Glu His Gly Arg Leu Ser Arg Lys Tyr Ile Tyr 
                325                 330                 335     


Ser Leu Tyr Trp Ser Xaa Leu Xaa Leu Xaa Xaa Ile Gly Glu Xaa Pro 
            340                 345                 350         


Pro Pro Val Lys Asp Glu Glu Tyr Leu Phe Val Val Val Asp Phe Leu 
        355                 360                 365             


Val Gly Val Leu Ile Phe Ala Xaa Ile Val Gly Asn Val Gly Ser Met 
    370                 375                 380                 


Ile Ser Asn Met Asn Ala Ser Arg Ala Glu Phe Gln Ala Lys Ile Asp 
385                 390                 395                 400 


Ser Ile Lys Gln Tyr Met Gln Phe Arg Lys Val Xaa Lys Asp Leu Glu 
                405                 410                 415     


Xaa Arg Val Ile Arg Trp Phe Asp Tyr Leu Trp Ala Asn Lys Lys Xaa 
            420                 425                 430         


Val Asp Glu Lys Glu Val Leu Lys Ser Leu Pro Asp Lys Leu Lys Ala 
        435                 440                 445             


Glu Ile Ala Ile Asn Val His Leu Asp Xaa Leu Lys Lys Val Arg Ile 
    450                 455                 460                 


Phe Gln Asp Cys Glu Ala Gly Leu Leu Val Glu Leu Val Leu Lys Leu 
465                 470                 475                 480 


Arg Pro Xaa Val Phe Ser Pro Gly Asp Tyr Ile Cys Lys Lys Gly Asp 
                485                 490                 495     


Ile Gly Lys Glu Met Tyr Ile Ile Asn Glu Gly Lys Leu Ala Val Val 
            500                 505                 510         


Ala Asp Asp Gly Val Xaa Gln Phe Val Val Leu Ser Asp Gly Ser Tyr 
        515                 520                 525             


Phe Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly Ser Lys Ser Gly Asn 
    530                 535                 540                 


Arg Arg Xaa Ala Asn Ile Arg Ser Ile Gly Tyr Ser Asp Leu Phe Cys 
545                 550                 555                 560 


Leu Ser Lys Asp Asp Leu Met Glu Ala Leu Xaa Glu Tyr Pro Glu Ala 
                565                 570                 575     


Lys Lys Ala Leu Glu Glu Lys Gly Arg Gln Ile Leu Met Lys Asp Asn 
            580                 585                 590         


Leu Ile Asp Glu Glu Leu Ala Arg Ala Gly Ala Asp Pro Lys Asp Leu 
        595                 600                 605             


Glu Glu Lys Val Glu Gln Leu Gly Ser Ser Leu Asp Xaa Leu Gln Xaa 
    610                 615                 620                 


Arg Phe Ala Arg Leu Leu Ala Glu Tyr Asn Ala Xaa Gln Met Lys Met 
625                 630                 635                 640 


Lys Gln Arg Leu Ser Gln Leu Glu Ser Gln Val Lys Gly Gly Gly Asp 
                645                 650                 655     


Lys Pro Leu Ala Asp Gly Glu Val Pro Gly Asp Ala Xaa Lys Xaa Glu 
            660                 665                 670         


Asp Lys Gln Gln 
        675     


<210> 6473
<211> 694
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<400> 6473
Met Ala Lys Ile Asn Xaa Gln Tyr Ser His Pro Ser Arg Xaa His Leu 
1               5                   10                  15      


Lys Val Lys Xaa Ser Asp Arg Asp Leu Asn Arg Ala Glu Asn Gly Leu 
            20                  25                  30          


Ser Arg Ala His Ser Ser Ser Glu Glu Xaa Ser Ser Val Leu Gln Pro 
        35                  40                  45              


Gly Ile Ala Met Glu Xaa Arg Gly Leu Ala Asp Ser Gly Gln Gly Ser 
    50                  55                  60                  


Phe Xaa Gly Gln Gly Ile Ala Arg Leu Ser Arg Leu Ile Phe Leu Leu 
65                  70                  75                  80  


Arg Arg Trp Ala Ala Arg His Val His His Gln Asp Gln Gly Pro Asp 
                85                  90                  95      


Ser Phe Pro Asp Arg Phe Arg Gly Ala Glu Leu Lys Glu Val Ser Ser 
            100                 105                 110         


Gln Glu Ser Asn Ala Gln Ala Asn Val Gly Ser Gln Glu Pro Ala Asp 
        115                 120                 125             


Arg Gly Arg Ser Ala Trp Pro Leu Ala Lys Cys Asn Xaa Asn Xaa Ser 
    130                 135                 140                 


Asn Asn Xaa Glu Glu Glu Lys Lys Xaa Lys Lys Lys Asp Ala Ile Val 
145                 150                 155                 160 


Val Asp Pro Ser Ser Asn Leu Tyr Tyr Arg Trp Leu Xaa Ala Ile Ala 
                165                 170                 175     


Leu Pro Val Phe Tyr Asn Trp Tyr Leu Leu Ile Cys Arg Ala Cys Phe 
            180                 185                 190         


Asp Glu Leu Gln Ser Glu Tyr Leu Met Leu Trp Leu Val Leu Asp Tyr 
        195                 200                 205             


Ser Ala Asp Val Leu Tyr Val Leu Asp Val Leu Val Arg Ala Arg Xaa 
    210                 215                 220                 


Gly Phe Leu Glu Gln Gly Leu Met Val Ser Asp Xaa Asn Arg Leu Trp 
225                 230                 235                 240 


Gln His Tyr Lys Xaa Xaa Xaa Gln Phe Lys Leu Asp Val Leu Ser Leu 
                245                 250                 255     


Val Pro Xaa Asp Leu Ala Tyr Leu Lys Val Gly Xaa Asn Tyr Pro Glu 
            260                 265                 270         


Val Arg Phe Asn Arg Leu Leu Lys Phe Ser Arg Leu Phe Glu Phe Phe 
        275                 280                 285             


Asp Arg Xaa Glu Xaa Arg Xaa Asn Tyr Pro Asn Met Phe Arg Ile Gly 
    290                 295                 300                 


Asn Leu Val Leu Tyr Ile Leu Ile Ile Ile His Trp Asn Ala Cys Ile 
305                 310                 315                 320 


Tyr Phe Ala Ile Ser Lys Phe Ile Gly Phe Gly Xaa Asp Ser Trp Val 
                325                 330                 335     


Tyr Pro Asn Ile Ser Ile Pro Glu His Gly Arg Leu Ser Arg Lys Tyr 
            340                 345                 350         


Ile Tyr Ser Leu Tyr Trp Ser Xaa Leu Xaa Leu Xaa Xaa Ile Gly Glu 
        355                 360                 365             


Xaa Pro Pro Pro Val Lys Asp Glu Glu Tyr Leu Phe Val Val Val Asp 
    370                 375                 380                 


Phe Leu Val Gly Val Leu Ile Phe Ala Xaa Ile Val Gly Asn Val Gly 
385                 390                 395                 400 


Ser Met Ile Ser Asn Met Asn Ala Ser Arg Ala Glu Phe Gln Ala Lys 
                405                 410                 415     


Ile Asp Ser Ile Lys Gln Tyr Met Gln Phe Arg Lys Val Xaa Lys Asp 
            420                 425                 430         


Leu Glu Xaa Arg Val Ile Arg Trp Phe Asp Tyr Leu Trp Ala Asn Lys 
        435                 440                 445             


Lys Xaa Val Asp Glu Lys Glu Val Leu Lys Ser Leu Pro Asp Lys Leu 
    450                 455                 460                 


Lys Ala Glu Ile Ala Ile Asn Val His Leu Asp Xaa Leu Lys Lys Val 
465                 470                 475                 480 


Arg Ile Phe Gln Asp Cys Glu Ala Gly Leu Leu Val Glu Leu Val Leu 
                485                 490                 495     


Lys Leu Arg Pro Xaa Val Phe Ser Pro Gly Asp Tyr Ile Cys Lys Lys 
            500                 505                 510         


Gly Asp Ile Gly Lys Glu Met Tyr Ile Ile Asn Glu Gly Lys Leu Ala 
        515                 520                 525             


Val Val Ala Asp Asp Gly Val Xaa Gln Phe Val Val Leu Ser Asp Gly 
    530                 535                 540                 


Ser Tyr Phe Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly Ser Lys Ser 
545                 550                 555                 560 


Gly Asn Arg Arg Xaa Ala Asn Ile Arg Ser Ile Gly Tyr Ser Asp Leu 
                565                 570                 575     


Phe Cys Leu Ser Lys Asp Asp Leu Met Glu Ala Leu Xaa Glu Tyr Pro 
            580                 585                 590         


Glu Ala Lys Lys Ala Leu Glu Glu Lys Gly Arg Gln Ile Leu Met Lys 
        595                 600                 605             


Asp Asn Leu Ile Asp Glu Glu Leu Ala Arg Ala Gly Ala Asp Pro Lys 
    610                 615                 620                 


Asp Leu Glu Glu Lys Val Glu Gln Leu Gly Ser Ser Leu Asp Xaa Leu 
625                 630                 635                 640 


Gln Xaa Arg Phe Ala Arg Leu Leu Ala Glu Tyr Asn Ala Xaa Gln Met 
                645                 650                 655     


Lys Met Lys Gln Arg Leu Ser Gln Leu Glu Ser Gln Val Lys Gly Gly 
            660                 665                 670         


Gly Asp Lys Pro Leu Ala Asp Gly Glu Val Pro Gly Asp Ala Xaa Lys 
        675                 680                 685             


Xaa Glu Asp Lys Gln Gln 
    690                 


<210> 6474
<211> 698
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<400> 6474
Met Glu Xaa Arg Gly Leu Ala Asp Ser Gly Gln Gly Ser Phe Xaa Gly 
1               5                   10                  15      


Gln Gly Ile Ala Arg Phe Gly Arg Ile Gln Lys Lys Ser Gln Pro Glu 
            20                  25                  30          


Lys Val Val Arg Ala Ala Ser Arg Gly Arg Pro Leu Ile Gly Trp Xaa 
        35                  40                  45              


Gln Trp Cys Ala Glu Asp Gly Gly Asp Glu Ser Glu Met Ala Leu Ala 
    50                  55                  60                  


Gly Ser Pro Gly Cys Ser Ser Gly Pro Gln Gly Arg Leu Ser Arg Leu 
65                  70                  75                  80  


Ile Phe Leu Leu Arg Arg Trp Ala Ala Arg His Val His His Gln Asp 
                85                  90                  95      


Gln Gly Pro Asp Ser Phe Pro Asp Arg Phe Arg Gly Ala Glu Leu Lys 
            100                 105                 110         


Glu Val Ser Ser Gln Glu Ser Asn Ala Gln Ala Asn Val Gly Ser Gln 
        115                 120                 125             


Glu Pro Ala Asp Arg Gly Arg Ser Ala Trp Pro Leu Ala Lys Cys Asn 
    130                 135                 140                 


Xaa Asn Xaa Ser Asn Asn Xaa Glu Glu Glu Lys Lys Xaa Lys Lys Lys 
145                 150                 155                 160 


Asp Ala Ile Val Val Asp Pro Ser Ser Asn Leu Tyr Tyr Arg Trp Leu 
                165                 170                 175     


Xaa Ala Ile Ala Leu Pro Val Phe Tyr Asn Trp Tyr Leu Leu Ile Cys 
            180                 185                 190         


Arg Ala Cys Phe Asp Glu Leu Gln Ser Glu Tyr Leu Met Leu Trp Leu 
        195                 200                 205             


Val Leu Asp Tyr Ser Ala Asp Val Leu Tyr Val Leu Asp Val Leu Val 
    210                 215                 220                 


Arg Ala Arg Xaa Gly Phe Leu Glu Gln Gly Leu Met Val Ser Asp Xaa 
225                 230                 235                 240 


Asn Arg Leu Trp Gln His Tyr Lys Xaa Xaa Xaa Gln Phe Lys Leu Asp 
                245                 250                 255     


Val Leu Ser Leu Val Pro Xaa Asp Leu Ala Tyr Leu Lys Val Gly Xaa 
            260                 265                 270         


Asn Tyr Pro Glu Val Arg Phe Asn Arg Leu Leu Lys Phe Ser Arg Leu 
        275                 280                 285             


Phe Glu Phe Phe Asp Arg Xaa Glu Xaa Arg Xaa Asn Tyr Pro Asn Met 
    290                 295                 300                 


Phe Arg Ile Gly Asn Leu Val Leu Tyr Ile Leu Ile Ile Ile His Trp 
305                 310                 315                 320 


Asn Ala Cys Ile Tyr Phe Ala Ile Ser Lys Phe Ile Gly Phe Gly Xaa 
                325                 330                 335     


Asp Ser Trp Val Tyr Pro Asn Ile Ser Ile Pro Glu His Gly Arg Leu 
            340                 345                 350         


Ser Arg Lys Tyr Ile Tyr Ser Leu Tyr Trp Ser Xaa Leu Xaa Leu Xaa 
        355                 360                 365             


Xaa Ile Gly Glu Xaa Pro Pro Pro Val Lys Asp Glu Glu Tyr Leu Phe 
    370                 375                 380                 


Val Val Val Asp Phe Leu Val Gly Val Leu Ile Phe Ala Xaa Ile Val 
385                 390                 395                 400 


Gly Asn Val Gly Ser Met Ile Ser Asn Met Asn Ala Ser Arg Ala Glu 
                405                 410                 415     


Phe Gln Ala Lys Ile Asp Ser Ile Lys Gln Tyr Met Gln Phe Arg Lys 
            420                 425                 430         


Val Xaa Lys Asp Leu Glu Xaa Arg Val Ile Arg Trp Phe Asp Tyr Leu 
        435                 440                 445             


Trp Ala Asn Lys Lys Xaa Val Asp Glu Lys Glu Val Leu Lys Ser Leu 
    450                 455                 460                 


Pro Asp Lys Leu Lys Ala Glu Ile Ala Ile Asn Val His Leu Asp Xaa 
465                 470                 475                 480 


Leu Lys Lys Val Arg Ile Phe Gln Asp Cys Glu Ala Gly Leu Leu Val 
                485                 490                 495     


Glu Leu Val Leu Lys Leu Arg Pro Xaa Val Phe Ser Pro Gly Asp Tyr 
            500                 505                 510         


Ile Cys Lys Lys Gly Asp Ile Gly Lys Glu Met Tyr Ile Ile Asn Glu 
        515                 520                 525             


Gly Lys Leu Ala Val Val Ala Asp Asp Gly Val Xaa Gln Phe Val Val 
    530                 535                 540                 


Leu Ser Asp Gly Ser Tyr Phe Gly Glu Ile Ser Ile Leu Asn Ile Lys 
545                 550                 555                 560 


Gly Ser Lys Ser Gly Asn Arg Arg Xaa Ala Asn Ile Arg Ser Ile Gly 
                565                 570                 575     


Tyr Ser Asp Leu Phe Cys Leu Ser Lys Asp Asp Leu Met Glu Ala Leu 
            580                 585                 590         


Xaa Glu Tyr Pro Glu Ala Lys Lys Ala Leu Glu Glu Lys Gly Arg Gln 
        595                 600                 605             


Ile Leu Met Lys Asp Asn Leu Ile Asp Glu Glu Leu Ala Arg Ala Gly 
    610                 615                 620                 


Ala Asp Pro Lys Asp Leu Glu Glu Lys Val Glu Gln Leu Gly Ser Ser 
625                 630                 635                 640 


Leu Asp Xaa Leu Gln Xaa Arg Phe Ala Arg Leu Leu Ala Glu Tyr Asn 
                645                 650                 655     


Ala Xaa Gln Met Lys Met Lys Gln Arg Leu Ser Gln Leu Glu Ser Gln 
            660                 665                 670         


Val Lys Gly Gly Gly Asp Lys Pro Leu Ala Asp Gly Glu Val Pro Gly 
        675                 680                 685             


Asp Ala Xaa Lys Xaa Glu Asp Lys Gln Gln 
    690                 695             


<210> 6475
<211> 1245
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<400> 6475
Met Leu Gly Trp Val Gln Arg Val Leu Pro Gln Pro Pro Gly Xaa Pro 
1               5                   10                  15      


Arg Lys Xaa Lys Met Gln Glu Glu Glu Glu Val Glu Pro Glu Pro Glu 
            20                  25                  30          


Met Glu Ala Glu Val Glu Pro Glu Pro Asn Pro Glu Glu Ala Glu Xaa 
        35                  40                  45              


Glu Ser Glu Ser Met Pro Pro Glu Glu Ser Phe Lys Glu Glu Glu Val 
    50                  55                  60                  


Ala Val Ala Asp Pro Ser Pro Gln Glu Xaa Lys Glu Ala Ala Leu Xaa 
65                  70                  75                  80  


Ser Xaa Ile Ser Leu Arg Ala Gln Gly Ala Glu Ile Ser Glu Met Asn 
                85                  90                  95      


Ser Pro Ser Arg Arg Val Leu Xaa Trp Leu Met Lys Gly Val Glu Lys 
            100                 105                 110         


Val Ile Pro Gln Pro Val His Ser Ile Xaa Glu Asp Pro Ala Gln Ile 
        115                 120                 125             


Leu Gly His Gly Ser Xaa Gly Asp Xaa Gly Cys Xaa Asp Glu Pro Asn 
    130                 135                 140                 


Glu Ala Leu Glu Ala Gln Asp Xaa Arg Pro Gly Leu Arg Leu Leu Leu 
145                 150                 155                 160 


Trp Leu Glu Gln Asn Leu Glu Arg Val Leu Pro Gln Pro Pro Lys Ser 
                165                 170                 175     


Ser Glu Val Trp Arg Asp Glu Pro Ala Val Ala Xaa Ala Pro Pro Gly 
            180                 185                 190         


Arg Pro Gln Glu Met Gly Pro Lys Leu Gln Ala Arg Glu Xaa Pro Ser 
        195                 200                 205             


Leu Pro Xaa Pro Ile Pro Leu Gln Pro Lys Glu Glu Pro Lys Glu Ala 
    210                 215                 220                 


Pro Ala Pro Glu Pro Gln Pro Gly Ser Gln Ala Gln Xaa Ser Ser Leu 
225                 230                 235                 240 


Pro Pro Xaa Arg Asp Pro Ala Arg Leu Val Ala Trp Val Leu His Arg 
                245                 250                 255     


Leu Glu Met Ala Leu Pro Gln Pro Val Leu His Gly Lys Ile Gly Glu 
            260                 265                 270         


Gln Glu Pro Asp Ser Pro Gly Ile Cys Asp Val Gln Xaa Ile Ser Ile 
        275                 280                 285             


Leu Pro Gly Gly Gln Val Glu Pro Asp Leu Val Leu Glu Glu Val Glu 
    290                 295                 300                 


Pro Pro Trp Glu Asp Ala His Gln Asp Val Ser Xaa Ser Pro Gln Gly 
305                 310                 315                 320 


Xaa Glu Val Val Pro Ala Tyr Glu Glu Glu Asn Lys Ala Val Glu Lys 
                325                 330                 335     


Met Pro Arg Glu Leu Ser Arg Ile Glu Glu Glu Lys Glu Asp Glu Glu 
            340                 345                 350         


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Val Xaa Glu 
        355                 360                 365             


Val Leu Leu Asp Ser Cys Val Val Ser Gln Val Gly Val Gly Gln Ser 
    370                 375                 380                 


Glu Glu Asp Gly Xaa Arg Pro Gln Ser Xaa Ser Asp Gln Lys Leu Trp 
385                 390                 395                 400 


Glu Glu Val Gly Glu Glu Ala Lys Lys Glu Ala Glu Glu Lys Ala Lys 
                405                 410                 415     


Glu Glu Ala Glu Glu Val Ala Glu Glu Glu Ala Glu Lys Glu Pro Gln 
            420                 425                 430         


Asp Trp Ala Glu Xaa Lys Glu Glu Pro Glu Ala Glu Ala Glu Ala Ala 
        435                 440                 445             


Ser Ser Gly Val Pro Ala Xaa Lys Gln His Pro Glu Val Gln Val Glu 
    450                 455                 460                 


Asp Xaa Asp Ala Asp Ser Cys Pro Leu Met Ala Glu Glu Asn Pro Pro 
465                 470                 475                 480 


Ser Xaa Val Leu Pro Pro Pro Ser Pro Ala Lys Ser Asp Xaa Leu Ile 
                485                 490                 495     


Val Pro Ser Ser Ala Ser Gly Xaa His Arg Lys Lys Leu Pro Ser Glu 
            500                 505                 510         


Asp Asp Glu Ala Glu Glu Leu Lys Ala Leu Ser Pro Ala Glu Ser Pro 
        515                 520                 525             


Val Val Ala Trp Ser Asp Pro Xaa Xaa Pro Lys Asp Xaa Asp Gly Gln 
    530                 535                 540                 


Asp Arg Ala Ala Ser Xaa Ala Ser Xaa Asn Ser Ala Ile Ile Asn Asp 
545                 550                 555                 560 


Arg Leu Gln Glu Leu Val Lys Leu Phe Lys Glu Arg Xaa Glu Lys Val 
                565                 570                 575     


Lys Glu Lys Leu Ile Asp Pro Asp Val Xaa Ser Asp Glu Glu Ser Pro 
            580                 585                 590         


Lys Pro Ser Pro Ala Lys Lys Ala Pro Glu Pro Ala Pro Asp Xaa Lys 
        595                 600                 605             


Pro Ala Glu Ala Glu Pro Val Glu Glu Glu His Tyr Cys Asp Met Leu 
    610                 615                 620                 


Cys Cys Lys Phe Lys His Arg Pro Trp Lys Lys Tyr Gln Phe Pro Gln 
625                 630                 635                 640 


Ser Ile Asp Pro Leu Xaa Asn Leu Met Tyr Val Leu Trp Leu Phe Phe 
                645                 650                 655     


Val Val Met Ala Trp Asn Trp Asn Cys Trp Leu Ile Pro Val Arg Trp 
            660                 665                 670         


Ala Phe Pro Tyr Gln Xaa Pro Asp Asn Ile His His Trp Leu Leu Met 
        675                 680                 685             


Asp Tyr Leu Cys Asp Leu Ile Tyr Phe Leu Asp Ile Xaa Val Phe Gln 
    690                 695                 700                 


Xaa Arg Leu Gln Phe Val Arg Gly Gly Asp Ile Ile Xaa Asp Lys Lys 
705                 710                 715                 720 


Asp Met Arg Asn Asn Tyr Leu Lys Ser Arg Arg Phe Lys Met Asp Leu 
                725                 730                 735     


Leu Ser Leu Leu Pro Leu Asp Phe Leu Tyr Leu Lys Val Gly Val Asn 
            740                 745                 750         


Pro Leu Leu Arg Leu Pro Arg Cys Leu Lys Tyr Met Ala Phe Phe Glu 
        755                 760                 765             


Phe Asn Ser Arg Leu Glu Ser Ile Leu Ser Lys Ala Tyr Val Tyr Arg 
    770                 775                 780                 


Val Ile Arg Xaa Xaa Ala Tyr Leu Leu Tyr Ser Leu His Leu Asn Ser 
785                 790                 795                 800 


Cys Leu Tyr Tyr Trp Ala Ser Ala Tyr Gln Gly Leu Gly Ser Xaa His 
                805                 810                 815     


Trp Val Tyr Asp Gly Val Gly Asn Ser Tyr Ile Arg Cys Tyr Tyr Phe 
            820                 825                 830         


Ala Val Lys Xaa Leu Ile Xaa Ile Gly Gly Leu Pro Asp Pro Lys Xaa 
        835                 840                 845             


Leu Phe Glu Ile Val Phe Gln Leu Leu Asn Tyr Phe Xaa Gly Val Phe 
    850                 855                 860                 


Ala Phe Ser Val Met Ile Gly Gln Met Arg Asp Val Val Gly Ala Ala 
865                 870                 875                 880 


Xaa Ala Gly Gln Xaa Tyr Tyr Arg Ser Cys Met Asp Ser Xaa Val Lys 
                885                 890                 895     


Tyr Met Asn Phe Tyr Lys Ile Pro Lys Ser Val Gln Asn Arg Val Lys 
            900                 905                 910         


Xaa Trp Tyr Glu Tyr Xaa Trp His Ser Gln Gly Met Leu Asp Glu Ser 
        915                 920                 925             


Glu Leu Met Val Gln Leu Pro Asp Lys Met Arg Leu Asp Leu Ala Ile 
    930                 935                 940                 


Asp Val Asn Tyr Asn Ile Val Ser Lys Val Ala Leu Phe Gln Gly Cys 
945                 950                 955                 960 


Asp Arg Gln Met Ile Phe Asp Met Leu Lys Arg Leu Arg Ser Val Val 
                965                 970                 975     


Tyr Leu Pro Asn Asp Tyr Val Cys Lys Lys Gly Glu Ile Gly Arg Glu 
            980                 985                 990         


Met Tyr Ile Ile Gln Ala Gly Gln  Val Gln Val Leu Gly  Gly Pro Asp 
        995                 1000                 1005             


Gly Lys  Ser Val Leu Val Xaa  Leu Lys Ala Gly Ser  Val Phe Gly 
    1010                 1015                 1020             


Glu Ile  Ser Leu Leu Ala Val  Gly Gly Gly Asn Arg  Arg Xaa Ala 
    1025                 1030                 1035             


Asn Val  Val Ala His Gly Phe  Xaa Asn Leu Phe Ile  Leu Asp Lys 
    1040                 1045                 1050             


Lys Asp  Leu Asn Glu Ile Leu  Val His Tyr Pro Glu  Ser Gln Lys 
    1055                 1060                 1065             


Leu Leu  Arg Lys Lys Ala Arg  Arg Met Leu Arg Ser  Asn Asn Lys 
    1070                 1075                 1080             


Pro Lys  Glu Glu Lys Ser Val  Leu Ile Leu Pro Pro  Arg Ala Gly 
    1085                 1090                 1095             


Xaa Pro  Lys Leu Phe Asn Ala  Ala Leu Ala Met Xaa  Gly Lys Met 
    1100                 1105                 1110             


Gly Gly  Lys Gly Ala Lys Gly  Gly Lys Leu Ala His  Leu Arg Ala 
    1115                 1120                 1125             


Arg Leu  Lys Glu Leu Ala Ala  Leu Glu Ala Ala Ala  Lys Gln Gln 
    1130                 1135                 1140             


Glu Leu  Val Glu Gln Ala Lys  Ser Ser Gln Asp Val  Lys Gly Glu 
    1145                 1150                 1155             


Glu Gly  Ser Ala Ala Pro Asp  Gln His Xaa His Pro  Lys Glu Ala 
    1160                 1165                 1170             


Ala Xaa  Asp Pro Pro Ala Pro  Arg Xaa Pro Pro Glu  Pro Pro Gly 
    1175                 1180                 1185             


Ser Pro  Pro Ser Ser Pro Pro  Pro Ala Ser Leu Gly  Arg Pro Glu 
    1190                 1195                 1200             


Gly Glu  Glu Glu Gly Pro Ala  Glu Pro Glu Glu His  Ser Val Arg 
    1205                 1210                 1215             


Ile Cys  Met Ser Pro Gly Pro  Glu Pro Gly Glu Gln  Ile Leu Ser 
    1220                 1225                 1230             


Val Lys  Met Pro Glu Glu Arg  Glu Glu Lys Ala Glu  
    1235                 1240                 1245 


<210> 6476
<211> 214
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<400> 6476
Met Leu Gly Trp Val Gln Arg Val Leu Pro Gln Pro Pro Gly Xaa Pro 
1               5                   10                  15      


Arg Lys Xaa Lys Met Gln Glu Glu Glu Glu Val Glu Pro Glu Pro Glu 
            20                  25                  30          


Met Glu Ala Glu Val Glu Pro Glu Pro Asn Pro Glu Glu Ala Glu Xaa 
        35                  40                  45              


Glu Ser Glu Ser Met Pro Pro Glu Glu Ser Phe Lys Glu Glu Glu Val 
    50                  55                  60                  


Ala Val Ala Asp Pro Ser Pro Gln Glu Xaa Lys Glu Ala Ala Leu Xaa 
65                  70                  75                  80  


Ser Xaa Ile Ser Leu Arg Ala Gln Gly Ala Glu Ile Ser Glu Met Asn 
                85                  90                  95      


Ser Pro Ser Arg Arg Val Leu Xaa Trp Leu Met Lys Gly Val Glu Lys 
            100                 105                 110         


Val Ile Pro Gln Pro Val His Ser Ile Xaa Glu Asp Pro Ala Gln Ile 
        115                 120                 125             


Leu Gly His Gly Ser Xaa Gly Asp Xaa Gly Cys Xaa Asp Glu Pro Asn 
    130                 135                 140                 


Glu Ala Leu Glu Ala Gln Asp Xaa Arg Pro Gly Leu Arg Leu Leu Leu 
145                 150                 155                 160 


Trp Leu Glu Gln Asn Leu Glu Arg Val Leu Pro Gln Pro Pro Lys Ser 
                165                 170                 175     


Ser Glu Val Trp Arg Asp Glu Pro Ala Val Ala Xaa Gly Ala Ala Ser 
            180                 185                 190         


Asp Pro Ala Pro Pro Gly Arg Pro Gln Glu Met Gly Pro Lys Leu Gln 
        195                 200                 205             


Ala Arg Glu Xaa Pro Ser 
    210                 


<210> 6477
<211> 299
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<400> 6477
Met Leu Gly Trp Val Gln Arg Val Leu Pro Gln Pro Pro Gly Xaa Pro 
1               5                   10                  15      


Arg Lys Xaa Lys Met Gln Glu Glu Glu Glu Val Glu Pro Glu Pro Glu 
            20                  25                  30          


Met Glu Ala Glu Val Glu Pro Glu Pro Asn Pro Glu Glu Ala Glu Xaa 
        35                  40                  45              


Glu Ser Glu Ser Met Pro Pro Glu Glu Ser Phe Lys Glu Glu Glu Val 
    50                  55                  60                  


Ala Val Ala Asp Pro Ser Pro Gln Glu Xaa Lys Glu Ala Ala Leu Xaa 
65                  70                  75                  80  


Ser Xaa Ile Ser Leu Arg Ala Gln Gly Ala Glu Ile Ser Glu Met Asn 
                85                  90                  95      


Ser Pro Ser Arg Arg Val Leu Xaa Trp Leu Met Lys Gly Val Glu Lys 
            100                 105                 110         


Val Ile Pro Gln Pro Val His Ser Ile Xaa Glu Asp Pro Ala Gln Ile 
        115                 120                 125             


Leu Gly His Gly Ser Xaa Gly Asp Xaa Gly Cys Xaa Asp Glu Pro Asn 
    130                 135                 140                 


Glu Ala Leu Glu Ala Gln Asp Xaa Arg Pro Gly Leu Arg Leu Leu Leu 
145                 150                 155                 160 


Trp Leu Glu Gln Asn Leu Glu Arg Val Leu Pro Gln Pro Pro Lys Ser 
                165                 170                 175     


Ser Glu Val Trp Arg Asp Glu Pro Ala Val Ala Xaa Gly Ala Ala Ser 
            180                 185                 190         


Asp Pro Ala Pro Pro Gly Arg Pro Gln Glu Met Gly Pro Lys Leu Gln 
        195                 200                 205             


Ala Arg Glu Xaa Pro Ser Leu Pro Xaa Pro Ile Pro Leu Gln Pro Lys 
    210                 215                 220                 


Glu Glu Pro Lys Glu Ala Pro Ala Pro Glu Pro Gln Pro Gly Ser Gln 
225                 230                 235                 240 


Ala Gln Xaa Ser Ser Leu Pro Pro Xaa Arg Asp Pro Ala Arg Leu Val 
                245                 250                 255     


Ala Trp Val Leu His Arg Leu Glu Met Ala Leu Pro Gln Pro Val Leu 
            260                 265                 270         


His Gly Lys Ile Gly Glu Gln Glu Pro Asp Ser Pro Gly Ile Cys Asp 
        275                 280                 285             


Val Gln Xaa Arg Val Met Gly Ala Gly Gly Leu 
    290                 295                 


<210> 6478
<211> 1251
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1052)..(1052)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1105)..(1105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<400> 6478
Met Leu Gly Trp Val Gln Arg Val Leu Pro Gln Pro Pro Gly Xaa Pro 
1               5                   10                  15      


Arg Lys Xaa Lys Met Gln Glu Glu Glu Glu Val Glu Pro Glu Pro Glu 
            20                  25                  30          


Met Glu Ala Glu Val Glu Pro Glu Pro Asn Pro Glu Glu Ala Glu Xaa 
        35                  40                  45              


Glu Ser Glu Ser Met Pro Pro Glu Glu Ser Phe Lys Glu Glu Glu Val 
    50                  55                  60                  


Ala Val Ala Asp Pro Ser Pro Gln Glu Xaa Lys Glu Ala Ala Leu Xaa 
65                  70                  75                  80  


Ser Xaa Ile Ser Leu Arg Ala Gln Gly Ala Glu Ile Ser Glu Met Asn 
                85                  90                  95      


Ser Pro Ser Arg Arg Val Leu Xaa Trp Leu Met Lys Gly Val Glu Lys 
            100                 105                 110         


Val Ile Pro Gln Pro Val His Ser Ile Xaa Glu Asp Pro Ala Gln Ile 
        115                 120                 125             


Leu Gly His Gly Ser Xaa Gly Asp Xaa Gly Cys Xaa Asp Glu Pro Asn 
    130                 135                 140                 


Glu Ala Leu Glu Ala Gln Asp Xaa Arg Pro Gly Leu Arg Leu Leu Leu 
145                 150                 155                 160 


Trp Leu Glu Gln Asn Leu Glu Arg Val Leu Pro Gln Pro Pro Lys Ser 
                165                 170                 175     


Ser Glu Val Trp Arg Asp Glu Pro Ala Val Ala Xaa Gly Ala Ala Ser 
            180                 185                 190         


Asp Pro Ala Pro Pro Gly Arg Pro Gln Glu Met Gly Pro Lys Leu Gln 
        195                 200                 205             


Ala Arg Glu Xaa Pro Ser Leu Pro Xaa Pro Ile Pro Leu Gln Pro Lys 
    210                 215                 220                 


Glu Glu Pro Lys Glu Ala Pro Ala Pro Glu Pro Gln Pro Gly Ser Gln 
225                 230                 235                 240 


Ala Gln Xaa Ser Ser Leu Pro Pro Xaa Arg Asp Pro Ala Arg Leu Val 
                245                 250                 255     


Ala Trp Val Leu His Arg Leu Glu Met Ala Leu Pro Gln Pro Val Leu 
            260                 265                 270         


His Gly Lys Ile Gly Glu Gln Glu Pro Asp Ser Pro Gly Ile Cys Asp 
        275                 280                 285             


Val Gln Xaa Ile Ser Ile Leu Pro Gly Gly Gln Val Glu Pro Asp Leu 
    290                 295                 300                 


Val Leu Glu Glu Val Glu Pro Pro Trp Glu Asp Ala His Gln Asp Val 
305                 310                 315                 320 


Ser Xaa Ser Pro Gln Gly Xaa Glu Val Val Pro Ala Tyr Glu Glu Glu 
                325                 330                 335     


Asn Lys Ala Val Glu Lys Met Pro Arg Glu Leu Ser Arg Ile Glu Glu 
            340                 345                 350         


Glu Lys Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        355                 360                 365             


Glu Glu Glu Val Xaa Glu Val Leu Leu Asp Ser Cys Val Val Ser Gln 
    370                 375                 380                 


Val Gly Val Gly Gln Ser Glu Glu Asp Gly Xaa Arg Pro Gln Ser Xaa 
385                 390                 395                 400 


Ser Asp Gln Lys Leu Trp Glu Glu Val Gly Glu Glu Ala Lys Lys Glu 
                405                 410                 415     


Ala Glu Glu Lys Ala Lys Glu Glu Ala Glu Glu Val Ala Glu Glu Glu 
            420                 425                 430         


Ala Glu Lys Glu Pro Gln Asp Trp Ala Glu Xaa Lys Glu Glu Pro Glu 
        435                 440                 445             


Ala Glu Ala Glu Ala Ala Ser Ser Gly Val Pro Ala Xaa Lys Gln His 
    450                 455                 460                 


Pro Glu Val Gln Val Glu Asp Xaa Asp Ala Asp Ser Cys Pro Leu Met 
465                 470                 475                 480 


Ala Glu Glu Asn Pro Pro Ser Xaa Val Leu Pro Pro Pro Ser Pro Ala 
                485                 490                 495     


Lys Ser Asp Xaa Leu Ile Val Pro Ser Ser Ala Ser Gly Xaa His Arg 
            500                 505                 510         


Lys Lys Leu Pro Ser Glu Asp Asp Glu Ala Glu Glu Leu Lys Ala Leu 
        515                 520                 525             


Ser Pro Ala Glu Ser Pro Val Val Ala Trp Ser Asp Pro Xaa Xaa Pro 
    530                 535                 540                 


Lys Asp Xaa Asp Gly Gln Asp Arg Ala Ala Ser Xaa Ala Ser Xaa Asn 
545                 550                 555                 560 


Ser Ala Ile Ile Asn Asp Arg Leu Gln Glu Leu Val Lys Leu Phe Lys 
                565                 570                 575     


Glu Arg Xaa Glu Lys Val Lys Glu Lys Leu Ile Asp Pro Asp Val Xaa 
            580                 585                 590         


Ser Asp Glu Glu Ser Pro Lys Pro Ser Pro Ala Lys Lys Ala Pro Glu 
        595                 600                 605             


Pro Ala Pro Asp Xaa Lys Pro Ala Glu Ala Glu Pro Val Glu Glu Glu 
    610                 615                 620                 


His Tyr Cys Asp Met Leu Cys Cys Lys Phe Lys His Arg Pro Trp Lys 
625                 630                 635                 640 


Lys Tyr Gln Phe Pro Gln Ser Ile Asp Pro Leu Xaa Asn Leu Met Tyr 
                645                 650                 655     


Val Leu Trp Leu Phe Phe Val Val Met Ala Trp Asn Trp Asn Cys Trp 
            660                 665                 670         


Leu Ile Pro Val Arg Trp Ala Phe Pro Tyr Gln Xaa Pro Asp Asn Ile 
        675                 680                 685             


His His Trp Leu Leu Met Asp Tyr Leu Cys Asp Leu Ile Tyr Phe Leu 
    690                 695                 700                 


Asp Ile Xaa Val Phe Gln Xaa Arg Leu Gln Phe Val Arg Gly Gly Asp 
705                 710                 715                 720 


Ile Ile Xaa Asp Lys Lys Asp Met Arg Asn Asn Tyr Leu Lys Ser Arg 
                725                 730                 735     


Arg Phe Lys Met Asp Leu Leu Ser Leu Leu Pro Leu Asp Phe Leu Tyr 
            740                 745                 750         


Leu Lys Val Gly Val Asn Pro Leu Leu Arg Leu Pro Arg Cys Leu Lys 
        755                 760                 765             


Tyr Met Ala Phe Phe Glu Phe Asn Ser Arg Leu Glu Ser Ile Leu Ser 
    770                 775                 780                 


Lys Ala Tyr Val Tyr Arg Val Ile Arg Xaa Xaa Ala Tyr Leu Leu Tyr 
785                 790                 795                 800 


Ser Leu His Leu Asn Ser Cys Leu Tyr Tyr Trp Ala Ser Ala Tyr Gln 
                805                 810                 815     


Gly Leu Gly Ser Xaa His Trp Val Tyr Asp Gly Val Gly Asn Ser Tyr 
            820                 825                 830         


Ile Arg Cys Tyr Tyr Phe Ala Val Lys Xaa Leu Ile Xaa Ile Gly Gly 
        835                 840                 845             


Leu Pro Asp Pro Lys Xaa Leu Phe Glu Ile Val Phe Gln Leu Leu Asn 
    850                 855                 860                 


Tyr Phe Xaa Gly Val Phe Ala Phe Ser Val Met Ile Gly Gln Met Arg 
865                 870                 875                 880 


Asp Val Val Gly Ala Ala Xaa Ala Gly Gln Xaa Tyr Tyr Arg Ser Cys 
                885                 890                 895     


Met Asp Ser Xaa Val Lys Tyr Met Asn Phe Tyr Lys Ile Pro Lys Ser 
            900                 905                 910         


Val Gln Asn Arg Val Lys Xaa Trp Tyr Glu Tyr Xaa Trp His Ser Gln 
        915                 920                 925             


Gly Met Leu Asp Glu Ser Glu Leu Met Val Gln Leu Pro Asp Lys Met 
    930                 935                 940                 


Arg Leu Asp Leu Ala Ile Asp Val Asn Tyr Asn Ile Val Ser Lys Val 
945                 950                 955                 960 


Ala Leu Phe Gln Gly Cys Asp Arg Gln Met Ile Phe Asp Met Leu Lys 
                965                 970                 975     


Arg Leu Arg Ser Val Val Tyr Leu Pro Asn Asp Tyr Val Cys Lys Lys 
            980                 985                 990         


Gly Glu Ile Gly Arg Glu Met Tyr  Ile Ile Gln Ala Gly  Gln Val Gln 
        995                 1000                 1005             


Val Leu  Gly Gly Pro Asp Gly  Lys Ser Val Leu Val  Xaa Leu Lys 
    1010                 1015                 1020             


Ala Gly  Ser Val Phe Gly Glu  Ile Ser Leu Leu Ala  Val Gly Gly 
    1025                 1030                 1035             


Gly Asn  Arg Arg Xaa Ala Asn  Val Val Ala His Gly  Phe Xaa Asn 
    1040                 1045                 1050             


Leu Phe  Ile Leu Asp Lys Lys  Asp Leu Asn Glu Ile  Leu Val His 
    1055                 1060                 1065             


Tyr Pro  Glu Ser Gln Lys Leu  Leu Arg Lys Lys Ala  Arg Arg Met 
    1070                 1075                 1080             


Leu Arg  Ser Asn Asn Lys Pro  Lys Glu Glu Lys Ser  Val Leu Ile 
    1085                 1090                 1095             


Leu Pro  Pro Arg Ala Gly Xaa  Pro Lys Leu Phe Asn  Ala Ala Leu 
    1100                 1105                 1110             


Ala Met  Xaa Gly Lys Met Gly  Gly Lys Gly Ala Lys  Gly Gly Lys 
    1115                 1120                 1125             


Leu Ala  His Leu Arg Ala Arg  Leu Lys Glu Leu Ala  Ala Leu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Lys Gln Gln Glu  Leu Val Glu Gln Ala  Lys Ser Ser 
    1145                 1150                 1155             


Gln Asp  Val Lys Gly Glu Glu  Gly Ser Ala Ala Pro  Asp Gln His 
    1160                 1165                 1170             


Xaa His  Pro Lys Glu Ala Ala  Xaa Asp Pro Pro Ala  Pro Arg Xaa 
    1175                 1180                 1185             


Pro Pro  Glu Pro Pro Gly Ser  Pro Pro Ser Ser Pro  Pro Pro Ala 
    1190                 1195                 1200             


Ser Leu  Gly Arg Pro Glu Gly  Glu Glu Glu Gly Pro  Ala Glu Pro 
    1205                 1210                 1215             


Glu Glu  His Ser Val Arg Ile  Cys Met Ser Pro Gly  Pro Glu Pro 
    1220                 1225                 1230             


Gly Glu  Gln Ile Leu Ser Val  Lys Met Pro Glu Glu  Arg Glu Glu 
    1235                 1240                 1245             


Lys Ala  Glu 
    1250     


<210> 6479
<211> 127
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<400> 6479
Xaa Asn Asp Tyr Val Cys Lys Lys Gly Glu Ile Gly Arg Glu Met Tyr 
1               5                   10                  15      


Ile Ile Gln Ala Gly Gln Val Gln Val Leu Gly Gly Pro Asp Gly Lys 
            20                  25                  30          


Ser Val Leu Val Xaa Leu Lys Ala Gly Ser Val Phe Gly Glu Ile Ser 
        35                  40                  45              


Leu Leu Ala Val Gly Gly Gly Asn Arg Arg Xaa Ala Asn Val Val Ala 
    50                  55                  60                  


His Gly Phe Xaa Asn Leu Phe Ile Leu Asp Lys Lys Asp Leu Asn Glu 
65                  70                  75                  80  


Ile Leu Val His Tyr Pro Glu Ser Gln Lys Leu Leu Arg Lys Lys Ala 
                85                  90                  95      


Arg Pro Arg Ala Arg Lys Xaa Ser Arg Glu Arg Lys Ala Pro Pro Pro 
            100                 105                 110         


Gln Xaa Ser Xaa Arg Xaa Gln Arg Arg Pro Pro Pro Xaa His Pro 
        115                 120                 125         


<210> 6480
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<400> 6480
Ala His Gly Phe Ala Asn Leu Leu Xaa Leu Asp Lys Lys Xaa Leu Gln 
1               5                   10                  15      


Glu Ile Leu Val His Tyr Pro Asp Ser Glu Arg Ile Leu Met Lys Lys 
            20                  25                  30          


Ala Arg Val Leu Leu Lys Gln Lys Ala Lys Xaa Ala Glu Ala Xaa Pro 
        35                  40                  45              


Pro Arg Lys Asp Leu Ala Leu Leu Phe Pro Pro Lys Glu Glu Xaa Pro 
    50                  55                  60                  


Lys Leu Phe Lys Xaa Leu Leu Gly Gly Xaa Gly Lys Ala Ser Leu Ala 
65                  70                  75                  80  


Arg Leu Leu Lys Leu Lys Arg Glu Gln Ala Ala Gln Gly Gln Phe Leu 
                85                  90                  95      


Pro Val Ser Phe Xaa Ala Gly Ile Phe Leu Gly His Leu Arg Leu 
            100                 105                 110     


<210> 6481
<211> 809
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<400> 6481
Met Phe Lys Ser Leu Xaa Lys Val Asn Lys Val Lys Pro Ile Gly Glu 
1               5                   10                  15      


Asn Asn Glu Asn Glu Gln Ser Ser Arg Arg Asn Glu Glu Gly Ser His 
            20                  25                  30          


Pro Ser Asn Gln Ser Gln Gln Xaa Xaa Ala Gln Glu Glu Asn Lys Gly 
        35                  40                  45              


Glu Glu Lys Ser Leu Lys Xaa Lys Ser Xaa Pro Val Xaa Ser Glu Glu 
    50                  55                  60                  


Pro His Xaa Asn Ile Gln Asp Lys Leu Ser Lys Lys Asn Ser Ser Gly 
65                  70                  75                  80  


Asp Leu Xaa Xaa Asn Pro Asp Pro Gln Asn Ala Ala Glu Pro Xaa Gly 
                85                  90                  95      


Xaa Val Pro Glu Gln Lys Glu Met Asp Pro Gly Lys Glu Gly Pro Asn 
            100                 105                 110         


Ser Pro Gln Asn Lys Pro Pro Ala Ala Pro Val Ile Asn Glu Tyr Ala 
        115                 120                 125             


Asp Ala Gln Leu His Asn Leu Val Lys Arg Met Arg Gln Arg Xaa Ala 
    130                 135                 140                 


Leu Tyr Lys Lys Lys Leu Val Glu Gly Asp Leu Ser Ser Pro Glu Ala 
145                 150                 155                 160 


Ser Pro Gln Xaa Ala Lys Pro Xaa Ala Val Pro Pro Val Lys Glu Ser 
                165                 170                 175     


Asp Asp Lys Pro Xaa Glu His Tyr Tyr Arg Leu Leu Trp Phe Lys Val 
            180                 185                 190         


Lys Lys Met Pro Leu Xaa Glu Tyr Leu Lys Arg Ile Lys Leu Pro Asn 
        195                 200                 205             


Ser Ile Asp Ser Tyr Xaa Asp Arg Leu Tyr Leu Leu Trp Leu Leu Leu 
    210                 215                 220                 


Val Xaa Leu Ala Tyr Asn Trp Asn Cys Cys Phe Ile Pro Leu Arg Leu 
225                 230                 235                 240 


Val Phe Pro Tyr Gln Xaa Ala Asp Asn Ile His Tyr Trp Leu Ile Ala 
                245                 250                 255     


Asp Ile Ile Cys Asp Ile Ile Tyr Leu Tyr Asp Met Leu Phe Ile Gln 
            260                 265                 270         


Pro Arg Leu Gln Phe Val Arg Gly Gly Asp Ile Ile Val Asp Ser Asn 
        275                 280                 285             


Glu Leu Arg Lys His Tyr Arg Xaa Ser Xaa Lys Phe Gln Leu Asp Val 
    290                 295                 300                 


Ala Ser Ile Ile Pro Phe Asp Ile Cys Tyr Leu Phe Phe Gly Phe Asn 
305                 310                 315                 320 


Pro Met Phe Arg Ala Asn Arg Met Leu Lys Tyr Xaa Ser Phe Phe Glu 
                325                 330                 335     


Phe Asn His His Leu Glu Ser Ile Met Asp Lys Ala Tyr Ile Tyr Arg 
            340                 345                 350         


Val Ile Arg Xaa Xaa Gly Tyr Leu Leu Phe Ile Leu His Ile Asn Ala 
        355                 360                 365             


Cys Val Tyr Tyr Trp Ala Ser Asn Tyr Glu Gly Ile Gly Xaa Xaa Arg 
    370                 375                 380                 


Trp Val Tyr Asp Gly Glu Gly Asn Glu Tyr Leu Arg Cys Tyr Tyr Trp 
385                 390                 395                 400 


Ala Val Arg Xaa Leu Ile Xaa Ile Gly Gly Leu Pro Glu Pro Gln Xaa 
                405                 410                 415     


Leu Phe Glu Ile Val Phe Gln Leu Leu Asn Phe Phe Ser Gly Val Phe 
            420                 425                 430         


Val Phe Ser Ser Leu Ile Gly Gln Met Arg Asp Val Ile Gly Ala Ala 
        435                 440                 445             


Xaa Ala Asn Gln Asn Tyr Phe Arg Ala Cys Met Asp Asp Xaa Ile Ala 
    450                 455                 460                 


Tyr Met Asn Asn Tyr Ser Ile Pro Lys Leu Val Gln Lys Arg Val Arg 
465                 470                 475                 480 


Xaa Trp Tyr Glu Tyr Xaa Trp Asp Ser Gln Arg Met Leu Asp Glu Ser 
                485                 490                 495     


Asp Leu Leu Lys Xaa Leu Pro Xaa Xaa Val Gln Leu Ala Leu Ala Ile 
            500                 505                 510         


Asp Val Asn Phe Ser Ile Ile Ser Lys Val Asp Leu Phe Lys Gly Cys 
        515                 520                 525             


Asp Xaa Gln Met Ile Tyr Asp Met Leu Leu Arg Leu Lys Ser Val Leu 
    530                 535                 540                 


Tyr Leu Pro Gly Asp Phe Val Cys Lys Lys Gly Glu Ile Gly Lys Glu 
545                 550                 555                 560 


Met Tyr Ile Ile Lys His Gly Glu Val Gln Val Leu Gly Gly Pro Asp 
                565                 570                 575     


Gly Xaa Lys Val Leu Val Xaa Leu Lys Ala Gly Ser Val Phe Gly Glu 
            580                 585                 590         


Ile Ser Leu Leu Ala Ala Gly Gly Gly Asn Arg Arg Xaa Ala Asn Val 
        595                 600                 605             


Val Ala His Gly Phe Ala Asn Leu Leu Xaa Leu Asp Lys Lys Xaa Leu 
    610                 615                 620                 


Gln Glu Ile Leu Val His Tyr Pro Asp Ser Glu Arg Ile Leu Met Lys 
625                 630                 635                 640 


Lys Ala Arg Val Leu Leu Lys Gln Lys Ala Lys Xaa Ala Glu Ala Xaa 
                645                 650                 655     


Pro Pro Arg Lys Asp Leu Ala Leu Leu Phe Pro Pro Lys Glu Glu Xaa 
            660                 665                 670         


Pro Lys Leu Phe Lys Xaa Leu Leu Gly Gly Xaa Gly Lys Ala Ser Leu 
        675                 680                 685             


Ala Arg Leu Leu Lys Leu Lys Arg Glu Gln Ala Ala Gln Lys Lys Glu 
    690                 695                 700                 


Asn Ser Glu Gly Gly Glu Glu Glu Gly Lys Glu Asn Glu Asp Lys Gln 
705                 710                 715                 720 


Lys Glu Asn Glu Asp Lys Gln Lys Glu Asn Glu Asp Lys Gly Lys Glu 
                725                 730                 735     


Asn Glu Asp Lys Asp Lys Gly Arg Glu Pro Glu Glu Lys Pro Leu Asp 
            740                 745                 750         


Arg Pro Glu Cys Xaa Ala Ser Pro Ile Ala Val Glu Glu Glu Pro His 
        755                 760                 765             


Ser Val Arg Arg Xaa Val Leu Pro Arg Gly Xaa Ser Arg Gln Ser Leu 
    770                 775                 780                 


Ile Ile Ser Met Ala Pro Ser Ala Glu Gly Gly Glu Glu Val Leu Xaa 
785                 790                 795                 800 


Ile Glu Val Lys Glu Lys Ala Lys Gln 
                805                 


<210> 6482
<211> 33
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<400> 6482
Met Ala Phe Xaa Phe Ala Ala Phe Cys Tyr Met Leu Ala Leu Leu Leu 
1               5                   10                  15      


Xaa Ala Ala Leu Ile Phe Phe Ala Ile Trp His Asp Lys Glu Glu Phe 
            20                  25                  30          


Gly 
    


<210> 6483
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(105)
<223> Selenocysteine

<400> 6483
Met Ala Phe Xaa Phe Ala Ala Phe Cys Tyr Met Leu Ala Leu Leu Leu 
1               5                   10                  15      


Xaa Ala Ala Leu Ile Phe Phe Ala Ile Trp His Ile Ile Ala Phe Asp 
            20                  25                  30          


Glu Leu Lys Xaa Asp Tyr Lys Asn Pro Ile Asp Gln Cys Asn Xaa Leu 
        35                  40                  45              


Asn Pro Leu Val Leu Pro Glu Tyr Leu Ile His Ala Phe Phe Cys Val 
    50                  55                  60                  


Met Phe Leu Cys Ala Ala Glu Trp Leu Xaa Leu Gly Leu Asn Met Pro 
65                  70                  75                  80  


Leu Leu Ala Tyr His Ile Trp Arg Tyr Met Ser Arg Pro Val Met Ser 
                85                  90                  95      


Gly Pro Gly Leu Tyr Asp Pro Xaa Xaa Ile Met Asn Ala Asp Ile Leu 
            100                 105                 110         


Ala Tyr Cys Gln Lys Glu Gly Trp Cys Lys Leu Ala Phe Tyr Leu Leu 
        115                 120                 125             


Ala Phe Phe Tyr Tyr Leu Tyr Gly 
    130                 135     


<210> 6484
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(105)
<223> Selenocysteine

<400> 6484
Met Ala Phe Xaa Phe Ala Ala Phe Cys Tyr Met Leu Ala Leu Leu Leu 
1               5                   10                  15      


Xaa Ala Ala Leu Ile Phe Phe Ala Ile Trp His Ile Ile Ala Phe Asp 
            20                  25                  30          


Glu Leu Lys Xaa Asp Tyr Lys Asn Pro Ile Asp Gln Cys Asn Xaa Leu 
        35                  40                  45              


Asn Pro Leu Val Leu Pro Glu Tyr Leu Ile His Ala Phe Phe Cys Val 
    50                  55                  60                  


Met Phe Leu Cys Ala Ala Glu Trp Leu Xaa Leu Gly Leu Asn Met Pro 
65                  70                  75                  80  


Leu Leu Ala Tyr His Ile Trp Arg Tyr Met Ser Arg Pro Val Met Ser 
                85                  90                  95      


Gly Pro Gly Leu Tyr Asp Pro Xaa Xaa Ile Met Asn Ala Asp Ile Leu 
            100                 105                 110         


Ala Tyr Cys Gln Lys Glu Gly Trp Cys Lys Leu Ala Phe Tyr Leu Leu 
        115                 120                 125             


Ala Phe Phe Tyr Tyr Leu Tyr Gly Met Ile Tyr Val Leu Val Ser Ser 
    130                 135                 140                 


<210> 6485
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<400> 6485
Met Ala Phe Xaa Phe Ala Ala Phe Cys Tyr Met Leu Ala Leu Leu Leu 
1               5                   10                  15      


Xaa Ala Ala Leu Ile Phe Phe Ala Ile Trp His Ile Ile Ala Phe Asp 
            20                  25                  30          


Glu Leu Lys Xaa Asp Tyr Lys Asn Pro Ile Asp Gln Cys Asn Xaa Leu 
        35                  40                  45              


Asn Pro Leu Val Leu Pro Glu Tyr Leu Ile His Ala Phe Phe Cys Val 
    50                  55                  60                  


Met Phe Leu Cys Ala Ala Glu Trp Leu Xaa Leu Gly Leu Asn Met Pro 
65                  70                  75                  80  


Leu Leu Ala Tyr His Ile Trp Ser Met Ile Tyr Val Leu Val Ser Ser 
                85                  90                  95      


<210> 6486
<211> 160
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(121)
<223> Selenocysteine

<400> 6486
Met Ala Phe Xaa Phe Ala Ala Phe Cys Tyr Met Leu Ala Leu Leu Leu 
1               5                   10                  15      


Xaa Ala Ala Leu Ile Phe Phe Ala Ile Trp His Ile Ile Ala Phe Asp 
            20                  25                  30          


Glu Leu Lys Xaa Asp Tyr Lys Asn Pro Ile Asp Gln Cys Asn Xaa Leu 
        35                  40                  45              


Asn Pro Xaa Val Glu Lys Val Lys Lys Ile Lys Arg Val Lys Ile Ala 
    50                  55                  60                  


Leu Lys Leu Val Leu Pro Glu Tyr Leu Ile His Ala Phe Phe Cys Val 
65                  70                  75                  80  


Met Phe Leu Cys Ala Ala Glu Trp Leu Xaa Leu Gly Leu Asn Met Pro 
                85                  90                  95      


Leu Leu Ala Tyr His Ile Trp Arg Tyr Met Ser Arg Pro Val Met Ser 
            100                 105                 110         


Gly Pro Gly Leu Tyr Asp Pro Xaa Xaa Ile Met Asn Ala Asp Ile Leu 
        115                 120                 125             


Ala Tyr Cys Gln Lys Glu Gly Trp Cys Lys Leu Ala Phe Tyr Leu Leu 
    130                 135                 140                 


Ala Phe Phe Tyr Tyr Leu Tyr Gly Met Ile Tyr Val Leu Val Ser Ser 
145                 150                 155                 160 


<210> 6487
<211> 53
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<400> 6487
Met Ala Phe Xaa Phe Ala Ala Phe Cys Tyr Met Leu Ala Leu Leu Leu 
1               5                   10                  15      


Xaa Ala Ala Leu Ile Phe Phe Ala Ile Trp His Ile Ile Ala Phe Asp 
            20                  25                  30          


Glu Leu Lys Xaa Asp Tyr Lys Asn Pro Ile Asp Gln Cys Asn Xaa Leu 
        35                  40                  45              


Asn Pro Val Tyr Glu 
    50              


<210> 6488
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(82)
<223> Selenocysteine

<400> 6488
Met Ala Phe Xaa Phe Ala Ala Phe Cys Tyr Met Leu Ala Leu Leu Leu 
1               5                   10                  15      


Xaa Ala Ala Leu Ile Phe Phe Ala Ile Trp His Leu Val Leu Pro Glu 
            20                  25                  30          


Tyr Leu Ile His Ala Phe Phe Cys Val Met Phe Leu Cys Ala Ala Glu 
        35                  40                  45              


Trp Leu Xaa Leu Gly Leu Asn Met Pro Leu Leu Ala Tyr His Ile Trp 
    50                  55                  60                  


Arg Tyr Met Ser Arg Pro Val Met Ser Gly Pro Gly Leu Tyr Asp Pro 
65                  70                  75                  80  


Xaa Xaa Ile Met Asn Ala Asp Ile Leu Ala Tyr Cys Gln Lys Glu Gly 
                85                  90                  95      


Trp Cys Lys Leu Ala Phe Tyr Leu Leu Ala Phe Phe Tyr Tyr Leu Tyr 
            100                 105                 110         


Gly Met Ile Tyr Val Leu Val Ser Ser 
        115                 120     


<210> 6489
<211> 312
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<400> 6489
Met Glu Pro Val Glu Xaa Trp Xaa Pro Gly Lys Val Ala Xaa Trp Leu 
1               5                   10                  15      


Arg Gly Leu Asp Asp Ser Leu Gln Asp Tyr Pro Phe Glu Asp Trp Gln 
            20                  25                  30          


Leu Pro Gly Lys Asn Leu Leu Gln Leu Cys Pro Gln Ser Leu Glu Ala 
        35                  40                  45              


Leu Ala Val Arg Ser Leu Gly His Gln Glu Leu Ile Leu Gly Gly Val 
    50                  55                  60                  


Glu Gln Leu Gln Ala Leu Ser Ser Arg Leu Gln Xaa Glu Asn Leu Gln 
65                  70                  75                  80  


Ser Leu Xaa Glu Gly Leu Leu Gly Ala Xaa His Asp Phe Gln Ser Ile 
                85                  90                  95      


Val Gln Gly Cys Leu Gly Asp Cys Ala Lys Xaa Pro Ile Asp Val Leu 
            100                 105                 110         


Cys Ala Ala Val Glu Leu Leu His Glu Ala Asp Ala Leu Leu Phe Trp 
        115                 120                 125             


Leu Ser Arg Tyr Leu Phe Ser His Leu Asn Asp Phe Ser Ala Cys Gln 
    130                 135                 140                 


Glu Ile Arg Asp Leu Leu Glu Glu Leu Ser Gln Val Leu His Glu Asp 
145                 150                 155                 160 


Gly Pro Ala Ala Glu Lys Glu Gly Xaa Val Leu Arg Ile Cys Ser His 
                165                 170                 175     


Val Ala Gly Ile Cys His Asn Ile Leu Val Cys Cys Pro Lys Glu Leu 
            180                 185                 190         


Leu Glu Gln Lys Ala Val Leu Glu Gln Val Gln Leu Asp Ser Pro Leu 
        195                 200                 205             


Gly Leu Glu Ile His Xaa Xaa Ser Asn Cys Gln His Phe Val Ser Gln 
    210                 215                 220                 


Val Asp Xaa Gln Val Pro Xaa Asp Ser Arg Leu Gln Ile Gln Pro Gly 
225                 230                 235                 240 


Asp Glu Val Val Gln Ile Asn Glu Gln Val Val Val Gly Trp Pro Arg 
                245                 250                 255     


Lys Asn Met Val Arg Glu Leu Leu Arg Glu Pro Ala Gly Leu Ser Leu 
            260                 265                 270         


Val Leu Lys Lys Ile Pro Ile Pro Glu Xaa Pro Pro Gln Val Xaa Gly 
        275                 280                 285             


Ser Val Gln Val Cys Leu Gly Gly Glu Xaa Val Gly Ser Ser His Pro 
    290                 295                 300                 


Pro Cys Pro Pro Gln Gly Pro Ile 
305                 310         


<210> 6490
<211> 713
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<400> 6490
Met Glu Pro Val Glu Xaa Trp Xaa Pro Gly Lys Val Ala Xaa Trp Leu 
1               5                   10                  15      


Arg Gly Leu Asp Asp Ser Leu Gln Asp Tyr Pro Phe Glu Asp Trp Gln 
            20                  25                  30          


Leu Pro Gly Lys Asn Leu Leu Gln Leu Cys Pro Gln Ser Leu Glu Ala 
        35                  40                  45              


Leu Ala Val Arg Ser Leu Gly His Gln Glu Leu Ile Leu Gly Gly Val 
    50                  55                  60                  


Glu Gln Leu Gln Ala Leu Ser Ser Arg Leu Gln Xaa Glu Asn Leu Gln 
65                  70                  75                  80  


Ser Leu Xaa Glu Gly Leu Leu Gly Ala Xaa His Asp Phe Gln Ser Ile 
                85                  90                  95      


Val Gln Gly Cys Leu Gly Asp Cys Ala Lys Xaa Pro Ile Asp Val Leu 
            100                 105                 110         


Cys Ala Ala Val Glu Leu Leu His Glu Ala Asp Ala Leu Leu Phe Trp 
        115                 120                 125             


Leu Ser Arg Tyr Leu Phe Ser His Leu Asn Asp Phe Ser Ala Cys Gln 
    130                 135                 140                 


Glu Ile Arg Asp Leu Leu Glu Glu Leu Ser Gln Val Leu His Glu Asp 
145                 150                 155                 160 


Gly Pro Ala Ala Glu Lys Glu Gly Xaa Val Leu Arg Ile Cys Ser His 
                165                 170                 175     


Val Ala Gly Ile Cys His Asn Ile Leu Val Cys Cys Pro Lys Glu Leu 
            180                 185                 190         


Leu Glu Gln Lys Ala Val Leu Glu Gln Val Gln Leu Asp Ser Pro Leu 
        195                 200                 205             


Gly Leu Glu Ile His Xaa Xaa Ser Asn Cys Gln His Phe Val Ser Gln 
    210                 215                 220                 


Val Asp Xaa Gln Val Pro Xaa Asp Ser Arg Leu Gln Ile Gln Pro Gly 
225                 230                 235                 240 


Asp Glu Val Val Gln Ile Asn Glu Gln Val Val Val Gly Trp Pro Arg 
                245                 250                 255     


Lys Asn Met Val Arg Glu Leu Leu Arg Glu Pro Ala Gly Leu Ser Leu 
            260                 265                 270         


Val Leu Lys Lys Ile Pro Ile Pro Glu Xaa Pro Pro Gln Xaa Pro Pro 
        275                 280                 285             


Gln Val Leu Asp Ser Pro His Gln Arg Ser Pro Ser Leu Ser Leu Ala 
    290                 295                 300                 


Pro Leu Ser Pro Arg Ala Pro Ser Glu Asp Val Phe Ala Phe Asp Leu 
305                 310                 315                 320 


Ser Ser Asn Pro Ser Pro Gly Pro Ser Pro Ala Trp Xaa Asp Ser Ala 
                325                 330                 335     


Ser Leu Gly Pro Glu Pro Leu Pro Ile Pro Pro Glu Pro Pro Ala Ile 
            340                 345                 350         


Leu Pro Ala Gly Val Ala Gly Xaa Pro Gly Leu Pro Glu Ser Pro Asp 
        355                 360                 365             


Lys Ser Pro Val Gly Arg Lys Lys Ser Lys Gly Leu Ala Xaa Arg Leu 
    370                 375                 380                 


Ser Arg Arg Arg Val Ser Cys Arg Glu Leu Gly Arg Pro Asp Cys Asp 
385                 390                 395                 400 


Gly Trp Leu Leu Leu Arg Lys Ala Pro Gly Gly Phe Met Gly Pro Arg 
                405                 410                 415     


Trp Arg Arg Arg Trp Phe Val Leu Lys Gly His Xaa Leu Tyr Trp Tyr 
            420                 425                 430         


Arg Gln Pro Gln Asp Glu Lys Ala Glu Gly Leu Ile Asn Val Ser Asn 
        435                 440                 445             


Tyr Ser Leu Glu Ser Gly His Asp Gln Lys Lys Lys Tyr Val Phe Gln 
    450                 455                 460                 


Leu Xaa His Asp Val Tyr Lys Pro Phe Ile Phe Ala Ala Asp Xaa Leu 
465                 470                 475                 480 


Xaa Asp Leu Ser Met Trp Val Arg His Leu Ile Xaa Cys Ile Ser Lys 
                485                 490                 495     


Tyr Gln Ser Pro Gly Arg Ala Pro Pro Pro Arg Glu Glu Asp Cys Tyr 
            500                 505                 510         


Ser Glu Xaa Glu Ala Glu Asp Pro Asp Asp Glu Ala Gly Ser His Ser 
        515                 520                 525             


Ala Ser Pro Ser Pro Ala Gln Ala Gly Ser Pro Leu His Gly Asp Xaa 
    530                 535                 540                 


Ser Pro Ala Ala Xaa Pro Xaa Gln Arg Ser Pro Arg Xaa Ser Phe Gly 
545                 550                 555                 560 


Ser Leu Xaa Asp Ser Ser Glu Glu Ala Leu Glu Gly Met Val Arg Gly 
                565                 570                 575     


Leu Arg Gln Gly Gly Val Ser Leu Leu Gly Gln Pro Gln Pro Leu Xaa 
            580                 585                 590         


Gln Glu Gln Trp Arg Ser Ser Phe Met Arg Arg Asn Arg Asp Pro Gln 
        595                 600                 605             


Leu Asn Glu Arg Val His Arg Val Arg Ala Leu Gln Ser Xaa Leu Lys 
    610                 615                 620                 


Ala Lys Leu Gln Glu Leu Gln Val Leu Glu Glu Val Leu Gly Asp Pro 
625                 630                 635                 640 


Glu Leu Xaa Gly Glu Lys Phe Arg Gln Trp Lys Glu Gln Asn Arg Glu 
                645                 650                 655     


Leu Tyr Ser Glu Gly Leu Gly Ala Trp Gly Val Ala Gln Ala Glu Gly 
            660                 665                 670         


Ser Ser His Ile Leu Xaa Ser Asp Ser Xaa Glu Gln Ser Pro His Ser 
        675                 680                 685             


Leu Pro Ser Asp Pro Glu Glu His Ser His Leu Cys Pro Leu Xaa Ser 
    690                 695                 700                 


Glu Ser Ser Leu Arg Pro Pro Asp Leu 
705                 710             


<210> 6491
<211> 720
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (710)..(710)
<223> Selenocysteine

<400> 6491
Met Glu Pro Val Glu Xaa Trp Xaa Pro Gly Lys Val Ala Xaa Trp Leu 
1               5                   10                  15      


Arg Gly Leu Asp Asp Ser Leu Gln Asp Tyr Pro Phe Glu Asp Trp Gln 
            20                  25                  30          


Leu Pro Gly Lys Asn Leu Leu Gln Leu Cys Pro Gln Ser Leu Glu Ala 
        35                  40                  45              


Leu Ala Val Arg Ser Leu Gly His Gln Glu Leu Ile Leu Gly Gly Val 
    50                  55                  60                  


Glu Gln Leu Gln Ala Leu Ser Ser Arg Leu Gln Xaa Glu Asn Leu Gln 
65                  70                  75                  80  


Ser Leu Xaa Glu Gly Leu Leu Gly Ala Xaa His Asp Phe Gln Ser Ile 
                85                  90                  95      


Val Gln Gly Cys Leu Gly Asp Cys Ala Lys Xaa Pro Ile Asp Val Leu 
            100                 105                 110         


Cys Ala Ala Val Glu Leu Leu His Glu Ala Asp Ala Leu Leu Phe Trp 
        115                 120                 125             


Leu Ser Arg Tyr Leu Phe Ser His Leu Asn Asp Phe Ser Ala Cys Gln 
    130                 135                 140                 


Glu Ile Arg Asp Leu Leu Glu Glu Leu Ser Gln Val Leu His Glu Asp 
145                 150                 155                 160 


Gly Pro Ala Ala Glu Lys Glu Gly Xaa Val Leu Arg Ile Cys Ser His 
                165                 170                 175     


Val Ala Gly Ile Cys His Asn Ile Leu Val Cys Cys Pro Lys Glu Leu 
            180                 185                 190         


Leu Glu Gln Lys Ala Val Leu Glu Gln Val Gln Leu Asp Ser Pro Leu 
        195                 200                 205             


Gly Leu Glu Ile His Xaa Xaa Ser Asn Cys Gln His Phe Val Ser Gln 
    210                 215                 220                 


Val Asp Xaa Gln Val Pro Xaa Asp Ser Arg Leu Gln Ile Gln Pro Gly 
225                 230                 235                 240 


Asp Glu Val Val Gln Ile Asn Glu Gln Val Val Val Arg Glu Glu Arg 
                245                 250                 255     


Asp Met Val Gly Trp Pro Arg Lys Asn Met Val Arg Glu Leu Leu Arg 
            260                 265                 270         


Glu Pro Ala Gly Leu Ser Leu Val Leu Lys Lys Ile Pro Ile Pro Glu 
        275                 280                 285             


Xaa Pro Pro Gln Xaa Pro Pro Gln Val Leu Asp Ser Pro His Gln Arg 
    290                 295                 300                 


Ser Pro Ser Leu Ser Leu Ala Pro Leu Ser Pro Arg Ala Pro Ser Glu 
305                 310                 315                 320 


Asp Val Phe Ala Phe Asp Leu Ser Ser Asn Pro Ser Pro Gly Pro Ser 
                325                 330                 335     


Pro Ala Trp Xaa Asp Ser Ala Ser Leu Gly Pro Glu Pro Leu Pro Ile 
            340                 345                 350         


Pro Pro Glu Pro Pro Ala Ile Leu Pro Ala Gly Val Ala Gly Xaa Pro 
        355                 360                 365             


Gly Leu Pro Glu Ser Pro Asp Lys Ser Pro Val Gly Arg Lys Lys Ser 
    370                 375                 380                 


Lys Gly Leu Ala Xaa Arg Leu Ser Arg Arg Arg Val Ser Cys Arg Glu 
385                 390                 395                 400 


Leu Gly Arg Pro Asp Cys Asp Gly Trp Leu Leu Leu Arg Lys Ala Pro 
                405                 410                 415     


Gly Gly Phe Met Gly Pro Arg Trp Arg Arg Arg Trp Phe Val Leu Lys 
            420                 425                 430         


Gly His Xaa Leu Tyr Trp Tyr Arg Gln Pro Gln Asp Glu Lys Ala Glu 
        435                 440                 445             


Gly Leu Ile Asn Val Ser Asn Tyr Ser Leu Glu Ser Gly His Asp Gln 
    450                 455                 460                 


Lys Lys Lys Tyr Val Phe Gln Leu Xaa His Asp Val Tyr Lys Pro Phe 
465                 470                 475                 480 


Ile Phe Ala Ala Asp Xaa Leu Xaa Asp Leu Ser Met Trp Val Arg His 
                485                 490                 495     


Leu Ile Xaa Cys Ile Ser Lys Tyr Gln Ser Pro Gly Arg Ala Pro Pro 
            500                 505                 510         


Pro Arg Glu Glu Asp Cys Tyr Ser Glu Xaa Glu Ala Glu Asp Pro Asp 
        515                 520                 525             


Asp Glu Ala Gly Ser His Ser Ala Ser Pro Ser Pro Ala Gln Ala Gly 
    530                 535                 540                 


Ser Pro Leu His Gly Asp Xaa Ser Pro Ala Ala Xaa Pro Xaa Gln Arg 
545                 550                 555                 560 


Ser Pro Arg Xaa Ser Phe Gly Ser Leu Xaa Asp Ser Ser Glu Glu Ala 
                565                 570                 575     


Leu Glu Gly Met Val Arg Gly Leu Arg Gln Gly Gly Val Ser Leu Leu 
            580                 585                 590         


Gly Gln Pro Gln Pro Leu Xaa Gln Glu Gln Trp Arg Ser Ser Phe Met 
        595                 600                 605             


Arg Arg Asn Arg Asp Pro Gln Leu Asn Glu Arg Val His Arg Val Arg 
    610                 615                 620                 


Ala Leu Gln Ser Xaa Leu Lys Ala Lys Leu Gln Glu Leu Gln Val Leu 
625                 630                 635                 640 


Glu Glu Val Leu Gly Asp Pro Glu Leu Xaa Gly Glu Lys Phe Arg Gln 
                645                 650                 655     


Trp Lys Glu Gln Asn Arg Glu Leu Tyr Ser Glu Gly Leu Gly Ala Trp 
            660                 665                 670         


Gly Val Ala Gln Ala Glu Gly Ser Ser His Ile Leu Xaa Ser Asp Ser 
        675                 680                 685             


Xaa Glu Gln Ser Pro His Ser Leu Pro Ser Asp Pro Glu Glu His Ser 
    690                 695                 700                 


His Leu Cys Pro Leu Xaa Ser Glu Ser Ser Leu Arg Pro Pro Asp Leu 
705                 710                 715                 720 


<210> 6492
<211> 229
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<400> 6492
Met Glu Pro Val Glu Xaa Trp Xaa Pro Gly Lys Val Ala Xaa Trp Leu 
1               5                   10                  15      


Arg Gly Leu Asp Asp Ser Leu Gln Asp Tyr Pro Phe Glu Asp Trp Gln 
            20                  25                  30          


Leu Pro Gly Lys Asn Leu Leu Gln Leu Cys Pro Gln Ser Leu Glu Ala 
        35                  40                  45              


Leu Ala Val Arg Ser Leu Gly His Gln Glu Leu Ile Leu Gly Gly Val 
    50                  55                  60                  


Glu Gln Leu Gln Ala Leu Ser Ser Arg Leu Gln Xaa Glu Asn Leu Gln 
65                  70                  75                  80  


Ser Leu Xaa Glu Gly Leu Leu Gly Ala Xaa His Asp Phe Gln Ser Ile 
                85                  90                  95      


Val Gln Gly Cys Leu Gly Asp Cys Ala Lys Xaa Pro Ile Asp Val Leu 
            100                 105                 110         


Cys Ala Ala Val Glu Leu Leu His Glu Ala Asp Ala Leu Leu Phe Trp 
        115                 120                 125             


Leu Ser Arg Tyr Leu Phe Ser His Leu Asn Asp Phe Ser Ala Cys Gln 
    130                 135                 140                 


Glu Ile Arg Asp Leu Leu Glu Glu Leu Ser Gln Val Leu His Glu Asp 
145                 150                 155                 160 


Gly Pro Ala Ala Glu Lys Glu Gly Xaa Val Leu Arg Ile Pro Arg Gly 
                165                 170                 175     


Trp Asp Leu Pro Gln His Pro Gly Leu Leu Pro Gln Gly Ala Ala Gly 
            180                 185                 190         


Xaa Glu Gly Arg Ala Arg Ala Gly Ala Ala Gly Gln Ser Ile Gly Pro 
        195                 200                 205             


Arg Asn Ser His His Gln Gln Leu Pro Ala Leu Cys Val Pro Ser Gly 
    210                 215                 220                 


His Pro Gly Ser His 
225                 


<210> 6493
<211> 63
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 6493
Met Glu Pro Val Glu Xaa Trp Xaa Pro Gly Lys Val Leu Xaa Xaa Pro 
1               5                   10                  15      


Cys Arg Xaa Ile Pro Leu Arg Xaa Gly Ser Cys Leu Ala Arg Xaa Cys 
            20                  25                  30          


Ser Ser Ser Ala Pro Lys Ala Ser Arg Leu Trp Leu Cys Gly Leu Trp 
        35                  40                  45              


Asp Xaa Arg Ser Ser Ser Trp Ala Gly Trp Asn Ser Ser Arg Pro 
    50                  55                  60              


<210> 6494
<211> 455
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<400> 6494
Met Val Arg Glu Leu Leu Arg Glu Pro Ala Gly Leu Ser Leu Val Leu 
1               5                   10                  15      


Lys Lys Ile Pro Ile Pro Glu Xaa Pro Pro Gln Xaa Pro Pro Gln Val 
            20                  25                  30          


Leu Asp Ser Pro His Gln Arg Ser Pro Ser Leu Ser Leu Ala Pro Leu 
        35                  40                  45              


Ser Pro Arg Ala Pro Ser Glu Asp Val Phe Ala Phe Asp Leu Ser Ser 
    50                  55                  60                  


Asn Pro Ser Pro Gly Pro Ser Pro Ala Trp Xaa Asp Ser Ala Ser Leu 
65                  70                  75                  80  


Gly Pro Glu Pro Leu Pro Ile Pro Pro Glu Pro Pro Ala Ile Leu Pro 
                85                  90                  95      


Ala Gly Val Ala Gly Xaa Pro Gly Leu Pro Glu Ser Pro Asp Lys Ser 
            100                 105                 110         


Pro Val Gly Arg Lys Lys Ser Lys Gly Leu Ala Xaa Arg Leu Ser Arg 
        115                 120                 125             


Arg Arg Val Ser Cys Arg Glu Leu Gly Arg Pro Asp Cys Asp Gly Trp 
    130                 135                 140                 


Leu Leu Leu Arg Lys Ala Pro Gly Gly Phe Met Gly Pro Arg Trp Arg 
145                 150                 155                 160 


Arg Arg Trp Phe Val Leu Lys Gly His Xaa Leu Tyr Trp Tyr Arg Gln 
                165                 170                 175     


Pro Gln Asp Glu Lys Ala Glu Gly Leu Ile Asn Val Ser Asn Tyr Ser 
            180                 185                 190         


Leu Glu Ser Gly His Asp Gln Lys Lys Lys Tyr Val Phe Gln Leu Xaa 
        195                 200                 205             


His Asp Val Tyr Lys Pro Phe Ile Phe Ala Ala Asp Xaa Leu Xaa Asp 
    210                 215                 220                 


Leu Ser Met Trp Val Arg His Leu Ile Xaa Cys Ile Ser Lys Tyr Gln 
225                 230                 235                 240 


Ser Pro Gly Arg Ala Pro Pro Pro Arg Glu Glu Asp Cys Tyr Ser Glu 
                245                 250                 255     


Xaa Glu Ala Glu Asp Pro Asp Asp Glu Ala Gly Ser His Ser Ala Ser 
            260                 265                 270         


Pro Ser Pro Ala Gln Ala Gly Ser Pro Leu His Gly Asp Xaa Ser Pro 
        275                 280                 285             


Ala Ala Xaa Pro Xaa Gln Arg Ser Pro Arg Xaa Ser Phe Gly Ser Leu 
    290                 295                 300                 


Xaa Asp Ser Ser Glu Glu Ala Leu Glu Gly Met Val Arg Gly Leu Arg 
305                 310                 315                 320 


Gln Gly Gly Val Ser Leu Leu Gly Gln Pro Gln Pro Leu Xaa Gln Glu 
                325                 330                 335     


Gln Trp Arg Ser Ser Phe Met Arg Arg Asn Arg Asp Pro Gln Leu Asn 
            340                 345                 350         


Glu Arg Val His Arg Val Arg Ala Leu Gln Ser Xaa Leu Lys Ala Lys 
        355                 360                 365             


Leu Gln Glu Leu Gln Val Leu Glu Glu Val Leu Gly Asp Pro Glu Leu 
    370                 375                 380                 


Xaa Gly Glu Lys Phe Arg Gln Trp Lys Glu Gln Asn Arg Glu Leu Tyr 
385                 390                 395                 400 


Ser Glu Gly Leu Gly Ala Trp Gly Val Ala Gln Ala Glu Gly Ser Ser 
                405                 410                 415     


His Ile Leu Xaa Ser Asp Ser Xaa Glu Gln Ser Pro His Ser Leu Pro 
            420                 425                 430         


Ser Asp Pro Glu Glu His Ser His Leu Cys Pro Leu Xaa Ser Glu Ser 
        435                 440                 445             


Ser Leu Arg Pro Pro Asp Leu 
    450                 455 


<210> 6495
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<400> 6495
Xaa Ile His Xaa Xaa Ser Asn Cys Gln His Phe Val Ser Gln Val Asp 
1               5                   10                  15      


Xaa Gln Val Pro Xaa Asp Ser Arg Leu Gln Ile Gln Pro Gly Asp Glu 
            20                  25                  30          


Val Val Gln Ile Asn Glu Gln Val Val Val Gly Trp Pro Arg Lys Asn 
        35                  40                  45              


Met Val Arg Glu Leu Leu Arg Glu Pro Ala Gly Leu Ser Leu Val Leu 
    50                  55                  60                  


Lys Lys Ile Pro Ile Pro Glu Xaa Pro Pro Gln Gly Pro Ile 
65                  70                  75              


<210> 6496
<211> 849
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<400> 6496
Met Ala Leu Ile Met Glu Pro Val Ser Lys Trp Ser Pro Ser Gln Val 
1               5                   10                  15      


Val Asp Trp Met Lys Gly Leu Asp Asp Cys Leu Gln Gln Tyr Ile Lys 
            20                  25                  30          


Asn Phe Glu Arg Glu Lys Ile Ser Gly Asp Gln Leu Leu Arg Ile Xaa 
        35                  40                  45              


His Gln Glu Leu Glu Asp Leu Gly Val Ser Arg Ile Gly His Gln Glu 
    50                  55                  60                  


Leu Ile Leu Glu Ala Val Asp Leu Leu Cys Ala Leu Asn Tyr Gly Leu 
65                  70                  75                  80  


Glu Xaa Glu Asn Leu Lys Xaa Leu Ser His Lys Leu Asn Ala Ser Ala 
                85                  90                  95      


Lys Asn Leu Gln Asn Phe Ile Xaa Gly Arg Arg Arg Ser Gly His Tyr 
            100                 105                 110         


Asp Gly Arg Xaa Ser Arg Lys Leu Pro Asn Asp Phe Leu Xaa Ser Val 
        115                 120                 125             


Val Asp Leu Ile Gly Ala Ala Lys Ser Leu Leu Ala Trp Leu Asp Arg 
    130                 135                 140                 


Ser Pro Phe Ala Ala Val Xaa Asp Tyr Ser Val Xaa Arg Asn Asn Val 
145                 150                 155                 160 


Ile Gln Leu Cys Leu Glu Leu Xaa Xaa Ile Val Gln Gln Asp Cys Xaa 
                165                 170                 175     


Val Tyr Glu Xaa Glu Asn Lys Ile Leu His Val Cys Lys Xaa Leu Ser 
            180                 185                 190         


Gly Val Cys Asp His Ile Ile Ser Leu Ser Ser Asp Pro Leu Val Ser 
        195                 200                 205             


Gln Ser Ala His Leu Glu Val Ile Gln Leu Ala Asn Ile Lys Pro Ser 
    210                 215                 220                 


Glu Gly Leu Gly Met Tyr Ile Lys Ser Xaa Tyr Asp Gly Leu His Val 
225                 230                 235                 240 


Ile Xaa Gly Xaa Xaa Glu Asn Ser Pro Ala Asp Arg Cys Lys Lys Ile 
                245                 250                 255     


His Ala Gly Asp Glu Val Ile Gln Val Asn His Gln Xaa Val Pro Leu 
            260                 265                 270         


Ile Pro Arg Ser Pro Xaa Ser Ser Val Ala Xaa Pro Ser Ser Xaa Ile 
        275                 280                 285             


Ser Xaa Pro Xaa Lys Arg Asp Ser Ser Ala Leu Gln Asp Leu Tyr Ile 
    290                 295                 300                 


Pro Pro Pro Pro Ala Glu Pro Tyr Ile Pro Arg Asp Glu Lys Gly Asn 
305                 310                 315                 320 


Leu Pro Cys Glu Asp Leu Arg Gly His Met Val Gly Lys Pro Val His 
                325                 330                 335     


Lys Gly Ser Glu Ser Pro Asn Ser Phe Leu Asp Gln Glu Tyr Arg Lys 
            340                 345                 350         


Arg Phe Asn Ile Val Glu Glu Asp Xaa Val Leu Tyr Cys Tyr Glu Tyr 
        355                 360                 365             


Glu Lys Gly Arg Ser Ser Ser Gln Gly Arg Arg Glu Ser Xaa Pro Xaa 
    370                 375                 380                 


Tyr Gly Lys Leu Arg Pro Ile Ser Met Pro Val Glu Tyr Asn Trp Val 
385                 390                 395                 400 


Gly Asp Tyr Glu Asp Pro Asn Lys Met Lys Arg Asp Ser Arg Arg Glu 
                405                 410                 415     


Asn Ser Leu Leu Arg Tyr Met Ser Asn Glu Lys Ile Ala Gln Glu Glu 
            420                 425                 430         


Tyr Met Phe Gln Arg Asn Ser Lys Lys Asp Xaa Gly Lys Lys Ser Lys 
        435                 440                 445             


Lys Lys Gly Asp Lys Ser Asn Ser Pro Xaa His Tyr Ser Leu Leu Pro 
    450                 455                 460                 


Ser Leu Gln Met Asp Ala Leu Arg Gln Asp Ile Met Gly Xaa Pro Val 
465                 470                 475                 480 


Pro Glu Xaa Xaa Leu Tyr His Xaa Phe Gln Gln Ser Ser Leu Gln His 
                485                 490                 495     


Lys Ser Lys Lys Lys Asn Lys Gly Pro Ile Ala Gly Lys Ser Lys Arg 
            500                 505                 510         


Arg Ile Ser Cys Lys Asp Leu Gly Arg Gly Asp Cys Glu Gly Trp Leu 
        515                 520                 525             


Trp Lys Lys Lys Asp Ala Lys Ser Tyr Phe Ser Gln Lys Trp Lys Lys 
    530                 535                 540                 


Tyr Trp Phe Val Leu Lys Asp Ala Ser Leu Tyr Trp Tyr Ile Asn Glu 
545                 550                 555                 560 


Glu Asp Glu Lys Ala Glu Gly Phe Ile Ser Leu Pro Glu Phe Lys Ile 
                565                 570                 575     


Asp Arg Ala Ser Glu Cys Arg Lys Lys Tyr Ala Phe Lys Ala Cys His 
            580                 585                 590         


Pro Lys Ile Lys Ser Phe Tyr Phe Ala Ala Glu His Leu Asp Asp Met 
        595                 600                 605             


Asn Arg Trp Leu Asn Arg Ile Asn Met Leu Xaa Ala Gly Tyr Ala Glu 
    610                 615                 620                 


Arg Glu Arg Ile Lys Gln Glu Gln Asp Tyr Trp Ser Glu Ser Asp Lys 
625                 630                 635                 640 


Glu Glu Ala Asp Xaa Pro Ser Xaa Pro Lys Gln Asp Ser Pro Pro Pro 
                645                 650                 655     


Pro Tyr Asp Xaa Tyr Pro Arg Pro Pro Ser Met Ser Cys Ala Ser Pro 
            660                 665                 670         


Tyr Val Glu Ala Lys His Ser Arg Leu Ser Ser Xaa Glu Xaa Ser Gln 
        675                 680                 685             


Ser Gln Ser Ser His Glu Glu Phe Arg Gln Glu Val Xaa Gly Ser Ser 
    690                 695                 700                 


Ala Val Ser Pro Ile Arg Lys Xaa Ala Ser Gln Arg Arg Ser Trp Gln 
705                 710                 715                 720 


Asp Leu Ile Glu Xaa Pro Leu Xaa Ser Ser Gly Leu His Tyr Leu Gln 
                725                 730                 735     


Xaa Leu Pro Leu Glu Asp Ser Val Phe Ser Asp Ser Ala Ala Ile Ser 
            740                 745                 750         


Pro Glu His Arg Arg Gln Ser Xaa Leu Pro Xaa Gln Lys Cys His Leu 
        755                 760                 765             


Gln Asp His Tyr Gly Pro Tyr Pro Leu Ala Glu Ser Glu Arg Met Gln 
    770                 775                 780                 


Val Leu Asn Gly Asn Gly Gly Lys Pro Arg Ser Phe Xaa Leu Pro Arg 
785                 790                 795                 800 


Asp Ser Gly Phe Asn His Cys Cys Leu Asn Ala Pro Val Ser Ala Cys 
                805                 810                 815     


Asp Pro Gln Asp Asp Val Gln Pro Pro Glu Val Glu Glu Glu Glu Glu 
            820                 825                 830         


Glu Glu Glu Glu Glu Gly Glu Ala Ala Gly Glu Asn Ile Gly Glu Lys 
        835                 840                 845             


Ser 
    


<210> 6497
<211> 898
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<400> 6497
Met Ala Leu Ile Met Glu Pro Val Ser Lys Trp Ser Pro Ser Gln Val 
1               5                   10                  15      


Val Asp Trp Met Lys Gly Leu Asp Asp Cys Leu Gln Gln Tyr Ile Lys 
            20                  25                  30          


Asn Phe Glu Arg Glu Lys Ile Ser Gly Asp Gln Leu Leu Arg Ile Xaa 
        35                  40                  45              


His Gln Glu Leu Glu Asp Leu Gly Val Ser Arg Ile Gly His Gln Glu 
    50                  55                  60                  


Leu Ile Leu Glu Ala Val Asp Leu Leu Cys Ala Leu Asn Tyr Gly Leu 
65                  70                  75                  80  


Glu Xaa Glu Asn Leu Lys Xaa Leu Ser His Lys Leu Asn Ala Ser Ala 
                85                  90                  95      


Lys Asn Leu Gln Asn Phe Ile Xaa Gly Arg Arg Arg Ser Gly His Tyr 
            100                 105                 110         


Asp Gly Arg Xaa Ser Arg Lys Leu Pro Asn Asp Phe Leu Xaa Ser Val 
        115                 120                 125             


Val Asp Leu Ile Gly Ala Ala Lys Ser Leu Leu Ala Trp Leu Asp Arg 
    130                 135                 140                 


Ser Pro Phe Ala Ala Val Xaa Asp Tyr Ser Val Xaa Arg Asn Asn Val 
145                 150                 155                 160 


Ile Gln Leu Cys Leu Glu Leu Xaa Xaa Ile Val Gln Gln Asp Cys Xaa 
                165                 170                 175     


Val Tyr Glu Xaa Glu Asn Lys Ile Leu His Val Cys Lys Xaa Leu Ser 
            180                 185                 190         


Gly Val Cys Asp His Ile Ile Ser Leu Ser Ser Asp Pro Leu Val Ser 
        195                 200                 205             


Gln Ser Ala His Leu Glu Val Ile Gln Leu Ala Asn Ile Lys Pro Ser 
    210                 215                 220                 


Glu Gly Leu Gly Met Tyr Ile Lys Ser Xaa Tyr Asp Gly Leu His Val 
225                 230                 235                 240 


Ile Xaa Gly Xaa Xaa Glu Asn Ser Pro Ala Asp Arg Cys Lys Lys Ile 
                245                 250                 255     


His Ala Gly Asp Glu Val Ile Gln Val Asn His Gln Xaa Val Val Gly 
            260                 265                 270         


Trp Gln Leu Lys Asn Leu Val Asn Ala Leu Arg Glu Asp Pro Ser Gly 
        275                 280                 285             


Val Ile Leu Xaa Leu Lys Lys Arg Pro Gln Ser Met Leu Xaa Ser Ala 
    290                 295                 300                 


Pro Ala Leu Leu Lys Asn Met Arg Trp Lys Pro Leu Ala Leu Gln Pro 
305                 310                 315                 320 


Leu Ile Pro Arg Ser Pro Xaa Ser Ser Val Ala Xaa Pro Ser Ser Xaa 
                325                 330                 335     


Ile Ser Xaa Pro Xaa Lys Arg Asp Ser Ser Ala Leu Gln Asp Leu Tyr 
            340                 345                 350         


Ile Pro Pro Pro Pro Ala Glu Pro Tyr Ile Pro Arg Asp Glu Lys Gly 
        355                 360                 365             


Asn Leu Pro Cys Glu Asp Leu Arg Gly His Met Val Gly Lys Pro Val 
    370                 375                 380                 


His Lys Gly Ser Glu Ser Pro Asn Ser Phe Leu Asp Gln Glu Tyr Arg 
385                 390                 395                 400 


Lys Arg Phe Asn Ile Val Glu Glu Asp Xaa Val Leu Tyr Cys Tyr Glu 
                405                 410                 415     


Tyr Glu Lys Gly Arg Ser Ser Ser Gln Gly Arg Arg Glu Ser Xaa Pro 
            420                 425                 430         


Xaa Tyr Gly Lys Leu Arg Pro Ile Ser Met Pro Val Glu Tyr Asn Trp 
        435                 440                 445             


Val Gly Asp Tyr Glu Asp Pro Asn Lys Met Lys Arg Asp Ser Arg Arg 
    450                 455                 460                 


Glu Asn Ser Leu Leu Arg Tyr Met Ser Asn Glu Lys Ile Ala Gln Glu 
465                 470                 475                 480 


Glu Tyr Met Phe Gln Arg Asn Ser Lys Lys Asp Xaa Gly Lys Lys Ser 
                485                 490                 495     


Lys Lys Lys Gly Asp Lys Ser Asn Ser Pro Xaa His Tyr Ser Leu Leu 
            500                 505                 510         


Pro Ser Leu Gln Met Asp Ala Leu Arg Gln Asp Ile Met Gly Xaa Pro 
        515                 520                 525             


Val Pro Glu Xaa Xaa Leu Tyr His Xaa Phe Gln Gln Ser Ser Leu Gln 
    530                 535                 540                 


His Lys Ser Lys Lys Lys Asn Lys Gly Pro Ile Ala Gly Lys Ser Lys 
545                 550                 555                 560 


Arg Arg Ile Ser Cys Lys Asp Leu Gly Arg Gly Asp Cys Glu Gly Trp 
                565                 570                 575     


Leu Trp Lys Lys Lys Asp Ala Lys Ser Tyr Phe Ser Gln Lys Trp Lys 
            580                 585                 590         


Lys Tyr Trp Phe Val Leu Lys Asp Ala Ser Leu Tyr Trp Tyr Ile Asn 
        595                 600                 605             


Glu Glu Asp Glu Lys Ala Glu Gly Phe Ile Ser Leu Pro Glu Phe Lys 
    610                 615                 620                 


Ile Asp Arg Ala Ser Glu Cys Arg Lys Lys Tyr Ala Phe Lys Ala Cys 
625                 630                 635                 640 


His Pro Lys Ile Lys Ser Phe Tyr Phe Ala Ala Glu His Leu Asp Asp 
                645                 650                 655     


Met Asn Arg Trp Leu Asn Arg Ile Asn Met Leu Xaa Ala Gly Tyr Ala 
            660                 665                 670         


Glu Arg Glu Arg Ile Lys Gln Glu Gln Asp Tyr Trp Ser Glu Ser Asp 
        675                 680                 685             


Lys Glu Glu Ala Asp Xaa Pro Ser Xaa Pro Lys Gln Asp Ser Pro Pro 
    690                 695                 700                 


Pro Pro Tyr Asp Xaa Tyr Pro Arg Pro Pro Ser Met Ser Cys Ala Ser 
705                 710                 715                 720 


Pro Tyr Val Glu Ala Lys His Ser Arg Leu Ser Ser Xaa Glu Xaa Ser 
                725                 730                 735     


Gln Ser Gln Ser Ser His Glu Glu Phe Arg Gln Glu Val Xaa Gly Ser 
            740                 745                 750         


Ser Ala Val Ser Pro Ile Arg Lys Xaa Ala Ser Gln Arg Arg Ser Trp 
        755                 760                 765             


Gln Asp Leu Ile Glu Xaa Pro Leu Xaa Ser Ser Gly Leu His Tyr Leu 
    770                 775                 780                 


Gln Xaa Leu Pro Leu Glu Asp Ser Val Phe Ser Asp Ser Ala Ala Ile 
785                 790                 795                 800 


Ser Pro Glu His Arg Arg Gln Ser Xaa Leu Pro Xaa Gln Lys Cys His 
                805                 810                 815     


Leu Gln Asp His Tyr Gly Pro Tyr Pro Leu Ala Glu Ser Glu Arg Met 
            820                 825                 830         


Gln Val Leu Asn Gly Asn Gly Gly Lys Pro Arg Ser Phe Xaa Leu Pro 
        835                 840                 845             


Arg Asp Ser Gly Phe Asn His Cys Cys Leu Asn Ala Pro Val Ser Ala 
    850                 855                 860                 


Cys Asp Pro Gln Asp Asp Val Gln Pro Pro Glu Val Glu Glu Glu Glu 
865                 870                 875                 880 


Glu Glu Glu Glu Glu Glu Gly Glu Ala Ala Gly Glu Asn Ile Gly Glu 
                885                 890                 895     


Lys Ser 
        


<210> 6498
<211> 1004
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (996)..(996)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<400> 6498
Met Ala Leu Ile Met Glu Pro Val Ser Lys Trp Ser Pro Ser Gln Val 
1               5                   10                  15      


Val Asp Trp Met Lys Gly Leu Asp Asp Cys Leu Gln Gln Tyr Ile Lys 
            20                  25                  30          


Asn Phe Glu Arg Glu Lys Ile Ser Gly Asp Gln Leu Leu Arg Ile Xaa 
        35                  40                  45              


His Gln Glu Leu Glu Asp Leu Gly Val Ser Arg Ile Gly His Gln Glu 
    50                  55                  60                  


Leu Ile Leu Glu Ala Val Asp Leu Leu Cys Ala Leu Asn Tyr Gly Leu 
65                  70                  75                  80  


Glu Xaa Glu Asn Leu Lys Xaa Leu Ser His Lys Leu Asn Ala Ser Ala 
                85                  90                  95      


Lys Asn Leu Gln Asn Phe Ile Xaa Gly Arg Arg Arg Ser Gly His Tyr 
            100                 105                 110         


Asp Gly Arg Xaa Ser Arg Lys Leu Pro Asn Asp Phe Leu Xaa Ser Val 
        115                 120                 125             


Val Asp Leu Ile Gly Ala Ala Lys Ser Leu Leu Ala Trp Leu Asp Arg 
    130                 135                 140                 


Ser Pro Phe Ala Ala Val Xaa Asp Tyr Ser Val Xaa Arg Asn Asn Val 
145                 150                 155                 160 


Ile Gln Leu Cys Leu Glu Leu Xaa Xaa Ile Val Gln Gln Asp Cys Xaa 
                165                 170                 175     


Val Tyr Glu Xaa Glu Asn Lys Ile Leu His Val Cys Lys Xaa Leu Ser 
            180                 185                 190         


Gly Val Cys Asp His Ile Ile Ser Leu Ser Ser Asp Pro Leu Val Ser 
        195                 200                 205             


Gln Ser Ala His Leu Glu Val Ile Gln Leu Ala Asn Ile Lys Pro Ser 
    210                 215                 220                 


Glu Gly Leu Gly Met Tyr Ile Lys Ser Xaa Tyr Asp Gly Leu His Val 
225                 230                 235                 240 


Ile Xaa Gly Xaa Xaa Glu Asn Ser Pro Ala Asp Arg Cys Lys Lys Ile 
                245                 250                 255     


His Ala Gly Asp Glu Val Ile Gln Val Asn His Gln Xaa Val Val Gly 
            260                 265                 270         


Trp Gln Leu Lys Asn Leu Val Asn Ala Leu Arg Glu Asp Pro Ser Gly 
        275                 280                 285             


Val Ile Leu Xaa Leu Lys Lys Arg Pro Gln Ser Met Leu Xaa Ser Ala 
    290                 295                 300                 


Pro Ala Leu Leu Lys Asn Met Arg Trp Lys Pro Leu Ala Leu Gln Pro 
305                 310                 315                 320 


Leu Ile Pro Arg Ser Pro Xaa Ser Ser Val Ala Xaa Pro Ser Ser Xaa 
                325                 330                 335     


Ile Ser Xaa Pro Xaa Lys Arg Asp Ser Ser Ala Leu Gln Asp Leu Tyr 
            340                 345                 350         


Ile Pro Pro Pro Pro Ala Glu Pro Tyr Ile Pro Arg Asp Glu Lys Gly 
        355                 360                 365             


Asn Leu Pro Cys Glu Asp Leu Arg Gly His Met Val Gly Lys Pro Val 
    370                 375                 380                 


His Lys Gly Ser Glu Ser Pro Asn Ser Phe Leu Asp Gln Glu Tyr Arg 
385                 390                 395                 400 


Lys Arg Phe Asn Ile Val Glu Glu Asp Xaa Val Leu Tyr Cys Tyr Glu 
                405                 410                 415     


Tyr Glu Lys Gly Arg Ser Ser Ser Gln Gly Arg Arg Glu Ser Xaa Pro 
            420                 425                 430         


Xaa Tyr Glu Asn Ser Leu Leu Arg Tyr Met Ser Asn Glu Lys Ile Ala 
        435                 440                 445             


Gln Glu Glu Tyr Met Phe Gln Arg Asn Ser Lys Lys Asp Xaa Gly Lys 
    450                 455                 460                 


Lys Ser Lys Lys Lys Gly Asp Lys Ser Asn Ser Pro Xaa His Tyr Ser 
465                 470                 475                 480 


Leu Leu Pro Ser Leu Gln Met Asp Ala Leu Arg Gln Asp Ile Met Gly 
                485                 490                 495     


Xaa Pro Val Pro Glu Xaa Xaa Leu Tyr His Xaa Phe Gln Gln Ser Ser 
            500                 505                 510         


Leu Gln His Lys Ser Lys Lys Lys Asn Lys Gly Pro Ile Ala Gly Lys 
        515                 520                 525             


Ser Lys Arg Arg Ile Ser Cys Lys Asp Leu Gly Arg Gly Asp Cys Glu 
    530                 535                 540                 


Gly Trp Leu Trp Lys Lys Lys Asp Ala Lys Ser Tyr Phe Ser Gln Lys 
545                 550                 555                 560 


Trp Lys Lys Tyr Trp Phe Val Leu Lys Asp Ala Ser Leu Tyr Trp Tyr 
                565                 570                 575     


Ile Asn Glu Glu Asp Glu Lys Ala Glu Gly Phe Ile Ser Leu Pro Glu 
            580                 585                 590         


Phe Lys Ile Asp Arg Ala Ser Glu Cys Arg Lys Lys Tyr Ala Phe Lys 
        595                 600                 605             


Ala Cys His Pro Lys Ile Lys Ser Phe Tyr Phe Ala Ala Glu His Leu 
    610                 615                 620                 


Asp Asp Met Asn Arg Trp Leu Asn Arg Ile Asn Met Leu Xaa Ala Gly 
625                 630                 635                 640 


Tyr Ala Glu Arg Glu Arg Ile Lys Gln Glu Gln Asp Tyr Trp Ser Glu 
                645                 650                 655     


Ser Asp Lys Glu Glu Ala Asp Xaa Pro Ser Xaa Pro Lys Gln Asp Ser 
            660                 665                 670         


Pro Pro Pro Pro Tyr Asp Xaa Tyr Pro Arg Pro Pro Ser Met Ser Cys 
        675                 680                 685             


Ala Ser Pro Tyr Val Glu Ala Lys His Ser Arg Leu Ser Ser Xaa Glu 
    690                 695                 700                 


Xaa Ser Gln Ser Gln Ser Ser His Glu Glu Phe Arg Gln Glu Val Xaa 
705                 710                 715                 720 


Gly Ser Ser Ala Val Ser Pro Ile Arg Lys Xaa Ala Ser Gln Arg Arg 
                725                 730                 735     


Ser Trp Gln Asp Leu Ile Glu Xaa Pro Leu Xaa Ser Ser Gly Leu His 
            740                 745                 750         


Tyr Leu Gln Xaa Leu Pro Leu Glu Asp Ser Val Phe Ser Asp Ser Ala 
        755                 760                 765             


Ala Ile Ser Pro Glu His Arg Arg Gln Ser Xaa Leu Pro Xaa Gln Lys 
    770                 775                 780                 


Cys His Leu Gln Asp His Tyr Gly Pro Tyr Pro Leu Ala Glu Ser Glu 
785                 790                 795                 800 


Arg Met Gln Val Leu Asn Gly Asn Gly Gly Lys Pro Arg Ser Phe Xaa 
                805                 810                 815     


Leu Pro Arg Asp Ser Gly Phe Asn His Cys Cys Leu Asn Ala Pro Val 
            820                 825                 830         


Ser Ala Cys Asp Pro Gln Asp Asp Val Gln Pro Pro Glu Val Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Glu Glu Glu Gly Glu Ala Ala Gly Glu Asn Ile 
    850                 855                 860                 


Gly Glu Lys Ser Glu Ser Arg Glu Glu Lys Leu Gly Asp Ser Leu Gln 
865                 870                 875                 880 


Asp Leu Tyr Arg Ala Leu Glu Gln Ala Ser Leu Ser Pro Leu Gly Glu 
                885                 890                 895     


His Arg Ile Ser Xaa Lys Met Glu Tyr Lys Leu Ser Phe Ile Lys Arg 
            900                 905                 910         


Cys Asn Asp Pro Val Met Asn Glu Lys Leu His Arg Leu Arg Ile Leu 
        915                 920                 925             


Lys Ser Xaa Leu Lys Ala Arg Glu Gly Glu Val Ala Ile Ile Asp Lys 
    930                 935                 940                 


Val Leu Asp Asn Pro Asp Leu Xaa Ser Lys Glu Phe Gln Gln Trp Lys 
945                 950                 955                 960 


Gln Met Tyr Leu Asp Leu Phe Leu Asp Ile Cys Gln Asn Xaa Xaa Ser 
                965                 970                 975     


Asn Asp Pro Leu Ser Ile Ser Ser Glu Val Asp Val Ile Xaa Ser Ser 
            980                 985                 990         


Leu Ala His Xaa His Ser Tyr Ile  Glu Xaa His Val 
        995                 1000                 


<210> 6499
<211> 1034
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1020)..(1020)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<400> 6499
Met Ala Leu Ile Met Glu Pro Val Ser Lys Trp Ser Pro Ser Gln Val 
1               5                   10                  15      


Val Asp Trp Met Lys Gly Leu Asp Asp Cys Leu Gln Gln Tyr Ile Lys 
            20                  25                  30          


Asn Phe Glu Arg Glu Lys Ile Ser Gly Asp Gln Leu Leu Arg Ile Xaa 
        35                  40                  45              


His Gln Glu Leu Glu Asp Leu Gly Val Ser Arg Ile Gly His Gln Glu 
    50                  55                  60                  


Leu Ile Leu Glu Ala Val Asp Leu Leu Cys Ala Leu Asn Tyr Gly Leu 
65                  70                  75                  80  


Glu Xaa Glu Asn Leu Lys Xaa Leu Ser His Lys Leu Asn Ala Ser Ala 
                85                  90                  95      


Lys Asn Leu Gln Asn Phe Ile Xaa Gly Arg Arg Arg Ser Gly His Tyr 
            100                 105                 110         


Asp Gly Arg Xaa Ser Arg Lys Leu Pro Asn Asp Phe Leu Xaa Ser Val 
        115                 120                 125             


Val Asp Leu Ile Gly Ala Ala Lys Ser Leu Leu Ala Trp Leu Asp Arg 
    130                 135                 140                 


Ser Pro Phe Ala Ala Val Xaa Asp Tyr Ser Val Xaa Arg Asn Asn Val 
145                 150                 155                 160 


Ile Gln Leu Cys Leu Glu Leu Xaa Xaa Ile Val Gln Gln Asp Cys Xaa 
                165                 170                 175     


Val Tyr Glu Xaa Glu Asn Lys Ile Leu His Val Cys Lys Xaa Leu Ser 
            180                 185                 190         


Gly Val Cys Asp His Ile Ile Ser Leu Ser Ser Asp Pro Leu Val Ser 
        195                 200                 205             


Gln Ser Ala His Leu Glu Val Ile Gln Leu Ala Asn Ile Lys Pro Ser 
    210                 215                 220                 


Glu Gly Leu Gly Met Tyr Ile Lys Ser Xaa Tyr Asp Gly Leu His Val 
225                 230                 235                 240 


Ile Xaa Gly Xaa Xaa Glu Asn Ser Pro Ala Asp Arg Cys Lys Lys Ile 
                245                 250                 255     


His Ala Gly Asp Glu Val Ile Gln Val Asn His Gln Xaa Val Val Gly 
            260                 265                 270         


Trp Gln Leu Lys Asn Leu Val Asn Ala Leu Arg Glu Asp Pro Ser Gly 
        275                 280                 285             


Val Ile Leu Xaa Leu Lys Lys Arg Pro Gln Ser Met Leu Xaa Ser Ala 
    290                 295                 300                 


Pro Ala Leu Leu Lys Asn Met Arg Trp Lys Pro Leu Ala Leu Gln Pro 
305                 310                 315                 320 


Leu Ile Pro Arg Ser Pro Xaa Ser Ser Val Ala Xaa Pro Ser Ser Xaa 
                325                 330                 335     


Ile Ser Xaa Pro Xaa Lys Arg Asp Ser Ser Ala Leu Gln Asp Leu Tyr 
            340                 345                 350         


Ile Pro Pro Pro Pro Ala Glu Pro Tyr Ile Pro Arg Asp Glu Lys Gly 
        355                 360                 365             


Asn Leu Pro Cys Glu Asp Leu Arg Gly His Met Val Gly Lys Pro Val 
    370                 375                 380                 


His Lys Gly Ser Glu Ser Pro Asn Ser Phe Leu Asp Gln Glu Tyr Arg 
385                 390                 395                 400 


Lys Arg Phe Asn Ile Val Glu Glu Asp Xaa Val Leu Tyr Cys Tyr Glu 
                405                 410                 415     


Tyr Glu Lys Gly Arg Ser Ser Ser Gln Gly Arg Arg Glu Ser Xaa Pro 
            420                 425                 430         


Xaa Tyr Gly Lys Leu Arg Pro Ile Ser Met Pro Val Glu Tyr Asn Trp 
        435                 440                 445             


Val Gly Asp Tyr Glu Asp Pro Asn Lys Met Lys Arg Asp Ser Arg Arg 
    450                 455                 460                 


Glu Asn Ser Leu Leu Arg Tyr Met Ser Asn Glu Lys Ile Ala Gln Glu 
465                 470                 475                 480 


Glu Tyr Met Phe Gln Arg Asn Ser Lys Lys Asp Xaa Gly Lys Lys Ser 
                485                 490                 495     


Lys Lys Lys Gly Asp Lys Ser Asn Ser Pro Xaa His Tyr Ser Leu Leu 
            500                 505                 510         


Pro Ser Leu Gln Met Asp Ala Leu Arg Gln Asp Ile Met Gly Xaa Pro 
        515                 520                 525             


Val Pro Glu Xaa Xaa Leu Tyr His Xaa Phe Gln Gln Ser Ser Leu Gln 
    530                 535                 540                 


His Lys Ser Lys Lys Lys Asn Lys Gly Pro Ile Ala Gly Lys Ser Lys 
545                 550                 555                 560 


Arg Arg Ile Ser Cys Lys Asp Leu Gly Arg Gly Asp Cys Glu Gly Trp 
                565                 570                 575     


Leu Trp Lys Lys Lys Asp Ala Lys Ser Tyr Phe Ser Gln Lys Trp Lys 
            580                 585                 590         


Lys Tyr Trp Phe Val Leu Lys Asp Ala Ser Leu Tyr Trp Tyr Ile Asn 
        595                 600                 605             


Glu Glu Asp Glu Lys Ala Glu Gly Phe Ile Ser Leu Pro Glu Phe Lys 
    610                 615                 620                 


Ile Asp Arg Ala Ser Glu Cys Arg Lys Lys Tyr Ala Phe Lys Ala Cys 
625                 630                 635                 640 


His Pro Lys Ile Lys Ser Phe Tyr Phe Ala Ala Glu His Leu Asp Asp 
                645                 650                 655     


Met Asn Arg Trp Leu Asn Arg Ile Asn Met Leu Xaa Ala Gly Tyr Ala 
            660                 665                 670         


Glu Arg Glu Arg Ile Lys Gln Glu Gln Asp Tyr Trp Ser Glu Ser Asp 
        675                 680                 685             


Lys Glu Glu Ala Asp Xaa Pro Ser Xaa Pro Lys Gln Asp Ser Pro Pro 
    690                 695                 700                 


Pro Pro Tyr Asp Xaa Tyr Pro Arg Pro Pro Ser Met Ser Cys Ala Ser 
705                 710                 715                 720 


Pro Tyr Val Glu Ala Lys His Ser Arg Leu Ser Ser Xaa Glu Xaa Ser 
                725                 730                 735     


Gln Ser Gln Ser Ser His Glu Glu Phe Arg Gln Glu Val Xaa Gly Ser 
            740                 745                 750         


Ser Ala Val Ser Pro Ile Arg Lys Xaa Ala Ser Gln Arg Arg Ser Trp 
        755                 760                 765             


Gln Asp Leu Ile Glu Xaa Pro Leu Xaa Ser Ser Gly Leu His Tyr Leu 
    770                 775                 780                 


Gln Xaa Leu Pro Leu Glu Asp Ser Val Phe Ser Asp Ser Ala Ala Ile 
785                 790                 795                 800 


Ser Pro Glu His Arg Arg Gln Ser Xaa Leu Pro Xaa Gln Lys Cys His 
                805                 810                 815     


Leu Gln Asp His Tyr Gly Pro Tyr Pro Leu Ala Glu Ser Glu Arg Met 
            820                 825                 830         


Gln Val Leu Asn Gly Asn Gly Gly Lys Pro Arg Ser Phe Xaa Leu Pro 
        835                 840                 845             


Arg Asp Ser Gly Phe Asn His Cys Cys Leu Asn Ala Pro Val Ser Ala 
    850                 855                 860                 


Cys Asp Pro Gln Asp Asp Val Gln Pro Pro Glu Val Glu Glu Glu Glu 
865                 870                 875                 880 


Glu Glu Glu Glu Glu Glu Gly Glu Ala Ala Gly Glu Asn Ile Gly Glu 
                885                 890                 895     


Lys Ser Glu Ser Arg Glu Glu Lys Leu Gly Asp Ser Leu Gln Asp Leu 
            900                 905                 910         


Tyr Arg Ala Leu Glu Gln Ala Ser Leu Ser Pro Leu Gly Glu His Arg 
        915                 920                 925             


Ile Ser Xaa Lys Met Glu Tyr Lys Leu Ser Phe Ile Lys Arg Cys Asn 
    930                 935                 940                 


Asp Pro Val Met Asn Glu Lys Leu His Arg Leu Arg Ile Leu Lys Ser 
945                 950                 955                 960 


Xaa Leu Lys Ala Arg Glu Gly Glu Val Ala Ile Ile Asp Lys Val Leu 
                965                 970                 975     


Asp Asn Pro Asp Leu Xaa Ser Lys Glu Phe Gln Gln Trp Lys Gln Met 
            980                 985                 990         


Tyr Leu Asp Leu Phe Leu Asp Ile  Cys Gln Asn Xaa Xaa  Ser Asn Asp 
        995                 1000                 1005             


Pro Leu  Ser Ile Ser Ser Glu  Val Asp Val Ile Xaa  Ser Ser Leu 
    1010                 1015                 1020             


Ala His  Xaa His Ser Tyr Ile  Glu Xaa His Val 
    1025                 1030                 


<210> 6500
<211> 555
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<400> 6500
Met Glu Pro Val Xaa Lys Trp Ser Pro Lys Gln Val Val Asp Trp Xaa 
1               5                   10                  15      


Arg Gly Leu Asp Asp Cys Leu Gln Gln Tyr Val His Lys Phe Glu Arg 
            20                  25                  30          


Glu Lys Ile Asn Gly Glu Gln Leu Leu Gln Ile Ser His Gln Asp Leu 
        35                  40                  45              


Glu Glu Leu Gly Val Xaa Arg Ile Gly His Gln Glu Leu Val Leu Glu 
    50                  55                  60                  


Ala Val Asp Leu Leu Cys Ala Leu Asn Tyr Gly Leu Glu Xaa Asp Asn 
65                  70                  75                  80  


Met Lys Asn Leu Val Leu Lys Leu Arg Ala Ser Ser His Asn Leu Gln 
                85                  90                  95      


Asn Tyr Ile Ser Ser Arg Arg Lys Ser Pro Ala Tyr Asp Gly Asn Xaa 
            100                 105                 110         


Ser Arg Lys Ala Pro Asn Glu Phe Leu Xaa Ser Val Val Glu Leu Ile 
        115                 120                 125             


Gly Ala Ala Lys Ala Leu Leu Ala Trp Leu Asp Arg Ala Pro Phe Xaa 
    130                 135                 140                 


Gly Ile Xaa Asp Phe Ser Val Xaa Lys Asn Lys Ile Ile Gln Leu Cys 
145                 150                 155                 160 


Leu Asp Leu Xaa Xaa Xaa Val Gln Lys Asp Cys Phe Val Ala Glu Met 
                165                 170                 175     


Glu Asp Lys Val Leu Xaa Val Val Lys Val Leu Asn Gly Ile Cys Asp 
            180                 185                 190         


Lys Xaa Ile Arg Ser Xaa Xaa Asp Pro Val Met Ser Gln Cys Ala Cys 
        195                 200                 205             


Leu Glu Glu Val His Leu Pro Asn Ile Lys Pro Gly Glu Gly Leu Gly 
    210                 215                 220                 


Met Tyr Ile Lys Ser Xaa Tyr Asp Gly Leu His Val Ile Xaa Gly Xaa 
225                 230                 235                 240 


Xaa Glu Asn Ser Pro Ala Asp Arg Ser Gln Lys Ile His Ala Gly Asp 
                245                 250                 255     


Glu Val Ile Gln Val Asn Gln Gln Xaa Val Val Gly Trp Gln Leu Lys 
            260                 265                 270         


Asn Leu Val Lys Lys Leu Arg Glu Asn Pro Xaa Gly Val Val Leu Leu 
        275                 280                 285             


Leu Lys Lys Arg Pro Xaa Gly Ser Phe Asn Phe Xaa Pro Ala Pro Leu 
    290                 295                 300                 


Lys Asn Leu Arg Trp Lys Pro Pro Leu Val Gln Xaa Ser Pro Pro Pro 
305                 310                 315                 320 


Ala Xaa Xaa Gln Ser Pro Glu Ser Xaa Met Asp Xaa Ser Leu Lys Lys 
                325                 330                 335     


Glu Lys Ser Ala Ile Leu Asp Leu Tyr Ile Pro Pro Pro Pro Ala Val 
            340                 345                 350         


Pro Tyr Ser Pro Arg Asp Glu Asn Gly Ser Phe Val Tyr Gly Gly Ser 
        355                 360                 365             


Ser Lys Cys Lys Gln Pro Leu Pro Gly Pro Lys Gly Ser Glu Ser Pro 
    370                 375                 380                 


Asn Ser Phe Leu Asp Gln Glu Ser Arg Arg Arg Arg Phe Xaa Ile Ala 
385                 390                 395                 400 


Asp Ser Asp Gln Leu Pro Gly Tyr Ser Val Glu Xaa Asn Ile Leu Pro 
                405                 410                 415     


Xaa Lys Met Arg Glu Lys Xaa Pro Ser Tyr Gly Lys Pro Arg Pro Leu 
            420                 425                 430         


Ser Met Pro Ala Asp Gly Asn Trp Met Gly Ile Val Asp Pro Phe Ala 
        435                 440                 445             


Arg Pro Arg Gly His Gly Arg Lys Gly Glu Asp Ala Leu Cys Arg Tyr 
    450                 455                 460                 


Phe Ser Asn Glu Arg Ile Pro Pro Ile Ile Glu Glu Ser Ser Ser Pro 
465                 470                 475                 480 


Pro Tyr Arg Phe Ser Arg Pro Xaa Xaa Glu Arg His Leu Val Arg Gly 
                485                 490                 495     


Ala Asp Tyr Ile Arg Gly Ser Arg Cys Tyr Ile Asn Ser Asp Leu His 
            500                 505                 510         


Ser Ser Ala Xaa Ile Pro Phe Gln Glu Glu Gly Xaa Lys Lys Lys Ser 
        515                 520                 525             


Gly Ser Ser Ala Xaa Lys Ser Ser Ser Xaa Glu Pro Ser Leu Leu Val 
    530                 535                 540                 


Ser Trp Phe Xaa Arg Leu Lys Leu Leu Xaa His 
545                 550                 555 


<210> 6501
<211> 475
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<400> 6501
Met Lys Asn Leu Val Leu Lys Leu Arg Ala Ser Ser His Asn Leu Gln 
1               5                   10                  15      


Asn Tyr Ile Ser Ser Arg Arg Lys Ser Pro Ala Tyr Asp Gly Asn Xaa 
            20                  25                  30          


Ser Arg Lys Ala Pro Asn Glu Phe Leu Xaa Ser Val Val Glu Leu Ile 
        35                  40                  45              


Gly Ala Ala Lys Ala Leu Leu Ala Trp Leu Asp Arg Ala Pro Phe Xaa 
    50                  55                  60                  


Gly Ile Xaa Asp Phe Ser Val Xaa Lys Asn Lys Ile Ile Gln Leu Cys 
65                  70                  75                  80  


Leu Asp Leu Xaa Xaa Xaa Val Gln Lys Asp Cys Phe Val Ala Glu Met 
                85                  90                  95      


Glu Asp Lys Val Leu Xaa Val Val Lys Val Leu Asn Gly Ile Cys Asp 
            100                 105                 110         


Lys Xaa Ile Arg Ser Xaa Xaa Asp Pro Val Met Ser Gln Cys Ala Cys 
        115                 120                 125             


Leu Glu Glu Val His Leu Pro Asn Ile Lys Pro Gly Glu Gly Leu Gly 
    130                 135                 140                 


Met Tyr Ile Lys Ser Xaa Tyr Asp Gly Leu His Val Ile Xaa Gly Xaa 
145                 150                 155                 160 


Xaa Glu Asn Ser Pro Ala Asp Arg Ser Gln Lys Ile His Ala Gly Asp 
                165                 170                 175     


Glu Val Ile Gln Val Asn Gln Gln Xaa Val Val Gly Trp Gln Leu Lys 
            180                 185                 190         


Asn Leu Val Lys Lys Leu Arg Glu Asn Pro Xaa Gly Val Val Leu Leu 
        195                 200                 205             


Leu Lys Lys Arg Pro Xaa Gly Ser Phe Asn Phe Xaa Pro Ala Pro Leu 
    210                 215                 220                 


Lys Asn Leu Arg Trp Lys Pro Pro Leu Val Gln Xaa Ser Pro Pro Pro 
225                 230                 235                 240 


Ala Xaa Xaa Gln Ser Pro Glu Ser Xaa Met Asp Xaa Ser Leu Lys Lys 
                245                 250                 255     


Glu Lys Ser Ala Ile Leu Asp Leu Tyr Ile Pro Pro Pro Pro Ala Val 
            260                 265                 270         


Pro Tyr Ser Pro Arg Asp Glu Asn Gly Ser Phe Val Tyr Gly Gly Ser 
        275                 280                 285             


Ser Lys Cys Lys Gln Pro Leu Pro Gly Pro Lys Gly Ser Glu Ser Pro 
    290                 295                 300                 


Asn Ser Phe Leu Asp Gln Glu Ser Arg Arg Arg Arg Phe Xaa Ile Ala 
305                 310                 315                 320 


Asp Ser Asp Gln Leu Pro Gly Tyr Ser Val Glu Xaa Asn Ile Leu Pro 
                325                 330                 335     


Xaa Lys Met Arg Glu Lys Xaa Pro Ser Tyr Gly Lys Pro Arg Pro Leu 
            340                 345                 350         


Ser Met Pro Ala Asp Gly Asn Trp Met Gly Ile Val Asp Pro Phe Ala 
        355                 360                 365             


Arg Pro Arg Gly His Gly Arg Lys Gly Glu Asp Ala Leu Cys Arg Tyr 
    370                 375                 380                 


Phe Ser Asn Glu Arg Ile Pro Pro Ile Ile Glu Glu Ser Ser Ser Pro 
385                 390                 395                 400 


Pro Tyr Arg Phe Ser Arg Pro Xaa Xaa Glu Arg His Leu Val Arg Gly 
                405                 410                 415     


Ala Asp Tyr Ile Arg Gly Ser Arg Cys Tyr Ile Asn Ser Asp Leu His 
            420                 425                 430         


Ser Ser Ala Xaa Ile Pro Phe Gln Glu Glu Gly Xaa Lys Lys Lys Ser 
        435                 440                 445             


Gly Ser Ser Ala Xaa Lys Ser Ser Ser Xaa Glu Pro Ser Leu Leu Val 
    450                 455                 460                 


Ser Trp Phe Xaa Arg Leu Lys Leu Leu Xaa His 
465                 470                 475 


<210> 6502
<211> 179
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<400> 6502
Asn Ile Lys Pro Gly Glu Gly Leu Gly Met Tyr Ile Lys Ser Xaa Tyr 
1               5                   10                  15      


Asp Gly Leu His Val Ile Xaa Gly Xaa Xaa Glu Asn Val Gly Trp Gln 
            20                  25                  30          


Leu Lys Asn Leu Val Lys Lys Leu Arg Glu Asn Pro Xaa Gly Val Val 
        35                  40                  45              


Leu Leu Leu Lys Lys Arg Pro Xaa Gly Ser Phe Asn Phe Xaa Pro Ala 
    50                  55                  60                  


Pro Leu Lys Asn Leu Arg Trp Lys Pro Pro Leu Val Gln Xaa Ser Pro 
65                  70                  75                  80  


Pro Pro Ala Xaa Xaa Gln Ser Pro Glu Ser Xaa Met Asp Xaa Ser Leu 
                85                  90                  95      


Lys Lys Glu Lys Ser Ala Ile Leu Asp Leu Tyr Ile Pro Pro Pro Pro 
            100                 105                 110         


Ala Val Pro Tyr Ser Pro Arg Asp Glu Asn Gly Ser Phe Val Tyr Gly 
        115                 120                 125             


Gly Ser Ser Lys Cys Lys Gln Pro Leu Pro Gly Pro Lys Gly Ser Glu 
    130                 135                 140                 


Ser Pro Asn Ser Phe Leu Asp Gln Glu Ser Arg Arg Arg Arg Phe Xaa 
145                 150                 155                 160 


Ile Ala Asp Ser Asp Gln Leu Pro Gly Tyr Ser Val Glu Xaa Asn Ile 
                165                 170                 175     


Leu Pro Xaa 
            


<210> 6503
<211> 25
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<400> 6503
Met Asn Leu Asp Ser Leu Ser Leu Ala Leu Ser Gln Ile Ser Tyr Leu 
1               5                   10                  15      


Val Asp Asn Leu Xaa Lys Lys Asn Tyr 
            20                  25  


<210> 6504
<211> 26
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<400> 6504
Met Asn Leu Asp Ser Leu Ser Leu Ala Leu Ser Gln Ile Ser Tyr Leu 
1               5                   10                  15      


Val Asp Asn Leu Xaa Lys Lys Asn Tyr Arg 
            20                  25      


<210> 6505
<211> 62
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<400> 6505
Met Asn Leu Asp Ser Leu Ser Leu Ala Leu Ser Gln Ile Ser Tyr Leu 
1               5                   10                  15      


Val Asp Asn Leu Xaa Lys Lys Asn Tyr Arg Ala Ser Gln Gln Glu Ile 
            20                  25                  30          


Gln His Ile Val Asn Arg His Gly Pro Glu Ala Asp Arg His Leu Leu 
        35                  40                  45              


Arg Cys Leu Phe Ser His Val Asp Phe Ser Gly Asp Gly Lys 
    50                  55                  60          


<210> 6506
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<400> 6506
Met Asn Leu Asp Ser Leu Ser Leu Ala Leu Ser Gln Ile Ser Tyr Leu 
1               5                   10                  15      


Val Asp Asn Leu Xaa Lys Lys Asn Tyr Arg Ala Ser Gln Gln Glu Ile 
            20                  25                  30          


Gln His Ile Val Asn Arg His Gly Pro Glu Ala Asp Arg His Leu Leu 
        35                  40                  45              


Arg Cys Leu Phe Ser His Val Asp Phe Ser Gly Asp Gly Lys Ser Ser 
    50                  55                  60                  


Gly Lys Asp Phe His Gln Xaa Gln Phe Leu Ile Gln Glu Cys Ala Leu 
65                  70                  75                  80  


Leu Ile Xaa Lys Pro Asn Cys Leu Glu Tyr Leu Met Trp Pro Arg Xaa 
                85                  90                  95      


<210> 6507
<211> 1551
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1058)..(1058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1213)..(1213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1339)..(1340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1343)..(1343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1375)..(1375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1379)..(1379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1418)..(1419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1449)..(1449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1456)..(1456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1467)..(1467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1490)..(1490)
<223> Selenocysteine

<400> 6507
Met Asn Leu Asp Ser Leu Ser Leu Ala Leu Ser Gln Ile Ser Tyr Leu 
1               5                   10                  15      


Val Asp Asn Leu Xaa Lys Lys Asn Tyr Arg Ala Ser Gln Gln Glu Ile 
            20                  25                  30          


Gln His Ile Val Asn Arg His Gly Pro Glu Ala Asp Arg His Leu Leu 
        35                  40                  45              


Arg Cys Leu Phe Ser His Val Asp Phe Ser Gly Asp Gly Lys Ser Ser 
    50                  55                  60                  


Gly Lys Asp Phe His Gln Xaa Gln Phe Leu Ile Gln Glu Cys Ala Leu 
65                  70                  75                  80  


Leu Ile Xaa Lys Pro Asn Phe Ile Ser Xaa Leu Ser Tyr Ala Ile Asp 
                85                  90                  95      


Asn Pro Leu His Tyr Gln Lys Ser Leu Lys Pro Ala Pro His Leu Phe 
            100                 105                 110         


Ala Gln Leu Ser Lys Val Leu Lys Leu Ser Lys Val Gln Glu Val Ile 
        115                 120                 125             


Phe Gly Leu Ala Leu Leu Asn Ser Ser Ser Ser Asp Leu Arg Gly Phe 
    130                 135                 140                 


Ala Ala Gln Phe Ile Lys Gln Lys Leu Pro Asp Leu Leu Arg Ser Tyr 
145                 150                 155                 160 


Ile Asp Ala Asp Val Ser Gly Asn Gln Glu Gly Gly Phe Gln Asp Ile 
                165                 170                 175     


Ala Ile Glu Val Leu His Leu Leu Leu Ser His Leu Leu Phe Gly Gln 
            180                 185                 190         


Lys Gly Ala Phe Gly Val Gly Gln Glu Gln Ile Asp Ala Phe Leu Lys 
        195                 200                 205             


Xaa Leu Arg Arg Asp Phe Pro Gln Glu Arg Cys Pro Val Val Leu Ala 
    210                 215                 220                 


Pro Leu Leu Tyr Pro Glu Lys Arg Asp Ile Leu Met Asp Arg Ile Leu 
225                 230                 235                 240 


Pro Asp Ser Gly Gly Val Ala Lys Xaa Met Met Glu Ser Ser Leu Ala 
                245                 250                 255     


Asp Phe Met Gln Glu Val Gly Tyr Gly Phe Cys Ala Ser Ile Glu Glu 
            260                 265                 270         


Cys Arg Asn Ile Ile Val Gln Phe Gly Val Arg Glu Val Xaa Ala Ala 
        275                 280                 285             


Gln Val Ala Arg Val Leu Gly Met Met Ala Arg Xaa His Ser Gly Leu 
    290                 295                 300                 


Xaa Asp Gly Ile Pro Leu Gln Ser Ile Ser Ala Pro Gly Ser Gly Ile 
305                 310                 315                 320 


Trp Ser Asp Gly Lys Asp Lys Ser Asp Gly Ala Gln Ala His Xaa Trp 
                325                 330                 335     


Asn Val Glu Val Leu Ile Asp Val Leu Lys Glu Leu Asn Pro Ser Leu 
            340                 345                 350         


Asn Phe Lys Glu Val Xaa Tyr Glu Leu Asp His Pro Gly Phe Gln Ile 
        355                 360                 365             


Arg Asp Ser Lys Gly Leu His Asn Val Val Tyr Gly Ile Gln Arg Gly 
    370                 375                 380                 


Leu Gly Met Glu Val Phe Pro Val Asp Leu Ile Tyr Arg Pro Trp Lys 
385                 390                 395                 400 


His Ala Glu Gly Gln Leu Ser Phe Ile Gln His Ser Leu Ile Asn Pro 
                405                 410                 415     


Glu Ile Phe Cys Phe Ala Asp Tyr Pro Cys His Xaa Val Ala Xaa Asp 
            420                 425                 430         


Ile Leu Lys Ala Pro Pro Glu Asp Asp Asn Arg Glu Ile Ala Xaa Trp 
        435                 440                 445             


Lys Ser Leu Asp Leu Ile Glu Ser Leu Leu Arg Leu Ala Glu Val Gly 
    450                 455                 460                 


Gln Tyr Glu Gln Val Lys Gln Leu Phe Ser Phe Pro Ile Lys His Cys 
465                 470                 475                 480 


Pro Asp Met Leu Val Leu Ala Leu Leu Gln Ile Asn Xaa Ser Trp His 
                485                 490                 495     


Xaa Leu Arg His Glu Leu Ile Ser Xaa Leu Met Pro Ile Phe Leu Gly 
            500                 505                 510         


Asn His Pro Asn Ser Ala Ile Ile Leu His Tyr Ala Trp His Gly Gln 
        515                 520                 525             


Gly Gln Ser Pro Ser Ile Arg Gln Leu Ile Met His Ala Met Ala Glu 
    530                 535                 540                 


Trp Tyr Met Arg Gly Glu Gln Tyr Asp Gln Ala Lys Leu Ser Arg Ile 
545                 550                 555                 560 


Leu Asp Val Ala Gln Asp Leu Lys Ala Leu Ser Met Leu Leu Asn Gly 
                565                 570                 575     


Xaa Pro Phe Ala Phe Val Ile Asp Leu Ala Ala Leu Ala Ser Arg Arg 
            580                 585                 590         


Glu Tyr Leu Lys Leu Asp Lys Trp Leu Xaa Asp Lys Ile Arg Glu His 
        595                 600                 605             


Gly Glu Pro Phe Ile Gln Ala Cys Met Xaa Phe Leu Lys Arg Arg Cys 
    610                 615                 620                 


Pro Ser Ile Leu Gly Gly Leu Ala Pro Glu Lys Asp Gln Pro Lys Ser 
625                 630                 635                 640 


Ala Gln Leu Pro Pro Glu Xaa Leu Ala Xaa Met Leu Ala Cys Leu Gln 
                645                 650                 655     


Ala Cys Ala Gly Ser Val Ser Gln Glu Leu Ser Glu Xaa Ile Leu Xaa 
            660                 665                 670         


Met Val Ala Asn Cys Ser Asn Val Met Asn Lys Ala Arg Gln Pro Pro 
        675                 680                 685             


Pro Gly Val Met Pro Lys Gly Arg Pro Pro Ser Ala Ser Ser Leu Asp 
    690                 695                 700                 


Ala Ile Ser Pro Val Gln Ile Asp Pro Leu Ala Gly Met Xaa Ser Leu 
705                 710                 715                 720 


Ser Ile Gly Gly Ser Ala Ala Pro His Xaa Gln Ser Met Gln Gly Phe 
                725                 730                 735     


Pro Pro Asn Leu Gly Ser Ala Phe Ser Xaa Pro Gln Ser Pro Ala Lys 
            740                 745                 750         


Ala Phe Pro Pro Leu Ser Xaa Pro Asn Gln Xaa Xaa Ala Phe Ser Gly 
        755                 760                 765             


Ile Gly Gly Leu Ser Ser Gln Leu Pro Val Gly Gly Leu Gly Xaa Gly 
    770                 775                 780                 


Ser Leu Xaa Gly Ile Gly Xaa Gly Ala Leu Gly Leu Pro Ala Val Asn 
785                 790                 795                 800 


Asn Asp Pro Phe Val Gln Arg Lys Leu Gly Xaa Ser Gly Leu Asn Gln 
                805                 810                 815     


Pro Xaa Phe Gln Gln Ser Lys Met Lys Pro Ser Asp Leu Ser Gln Val 
            820                 825                 830         


Trp Pro Glu Ala Asn Gln His Phe Ser Lys Glu Ile Asp Asp Glu Ala 
        835                 840                 845             


Asn Ser Tyr Phe Gln Arg Ile Tyr Asn His Pro Pro His Pro Xaa Met 
    850                 855                 860                 


Ser Val Asp Glu Val Leu Glu Met Leu Gln Arg Phe Lys Asp Ser Xaa 
865                 870                 875                 880 


Ile Lys Arg Glu Arg Glu Val Phe Asn Cys Met Leu Arg Asn Leu Phe 
                885                 890                 895     


Glu Glu Tyr Arg Phe Phe Pro Gln Tyr Pro Asp Lys Glu Leu His Ile 
            900                 905                 910         


Xaa Ala Cys Leu Phe Gly Gly Ile Ile Glu Lys Gly Leu Val Xaa Tyr 
        915                 920                 925             


Met Ala Leu Gly Leu Ala Leu Arg Tyr Val Leu Glu Ala Leu Arg Lys 
    930                 935                 940                 


Pro Phe Gly Ser Lys Met Tyr Tyr Phe Gly Ile Ala Ala Leu Asp Arg 
945                 950                 955                 960 


Phe Lys Asn Arg Leu Lys Asp Tyr Pro Gln Tyr Cys Gln His Leu Ala 
                965                 970                 975     


Ser Ile Ser His Phe Met Gln Phe Pro His His Leu Gln Glu Tyr Ile 
            980                 985                 990         


Glu Tyr Gly Gln Gln Ser Arg Asp  Pro Pro Val Lys Met  Gln Gly Ser 
        995                 1000                 1005             


Ile Xaa  Xaa Pro Gly Ser Ile  Ala Leu Ala Gln Ala  Gln Ala Gln 
    1010                 1015                 1020             


Ala Gln  Val Pro Ala Lys Ala  Pro Leu Ala Gly Gln  Val Ser Xaa 
    1025                 1030                 1035             


Met Val  Xaa Xaa Ser Xaa Xaa  Xaa Xaa Val Ala Lys  Xaa Val Xaa 
    1040                 1045                 1050             


Val Xaa  Arg Pro Xaa Gly Val  Ser Phe Lys Lys Asp  Val Pro Pro 
    1055                 1060                 1065             


Ser Ile  Asn Xaa Xaa Asn Ile  Asp Xaa Leu Leu Val  Ala Xaa Asp 
    1070                 1075                 1080             


Gln Xaa  Glu Arg Ile Val Glu  Pro Pro Glu Asn Ile  Gln Glu Lys 
    1085                 1090                 1095             


Ile Ala  Phe Ile Phe Asn Asn  Leu Ser Gln Ser Asn  Met Xaa Gln 
    1100                 1105                 1110             


Lys Val  Glu Glu Leu Lys Glu  Xaa Val Lys Glu Glu  Phe Met Pro 
    1115                 1120                 1125             


Trp Val  Ser Gln Tyr Leu Val  Met Lys Arg Val Ser  Ile Glu Pro 
    1130                 1135                 1140             


Asn Phe  His Ser Leu Tyr Ser  Asn Phe Leu Asp Xaa  Leu Lys Asn 
    1145                 1150                 1155             


Pro Glu  Phe Asn Lys Met Val  Leu Asn Glu Xaa Tyr  Arg Asn Ile 
    1160                 1165                 1170             


Lys Val  Leu Leu Xaa Ser Asp  Lys Ala Ala Ala Asn  Phe Ser Asp 
    1175                 1180                 1185             


Arg Ser  Leu Leu Lys Asn Leu  Gly His Trp Leu Gly  Met Ile Xaa 
    1190                 1195                 1200             


Leu Ala  Lys Asn Lys Pro Ile  Leu His Xaa Asp Leu  Asp Val Lys 
    1205                 1210                 1215             


Ser Leu  Leu Leu Glu Ala Tyr  Val Lys Gly Gln Gln  Glu Leu Leu 
    1220                 1225                 1230             


Tyr Val  Val Pro Phe Val Ala  Lys Val Leu Glu Ser  Ser Ile Arg 
    1235                 1240                 1245             


Ser Val  Val Phe Arg Pro Pro  Asn Pro Trp Xaa Met  Ala Ile Met 
    1250                 1255                 1260             


Asn Val  Leu Ala Glu Leu His  Gln Glu His Asp Leu  Lys Leu Asn 
    1265                 1270                 1275             


Leu Lys  Phe Glu Ile Glu Val  Leu Cys Lys Asn Leu  Ala Leu Asp 
    1280                 1285                 1290             


Ile Asn  Glu Leu Lys Pro Gly  Asn Leu Leu Lys Asp  Lys Asp Arg 
    1295                 1300                 1305             


Leu Lys  Asn Leu Asp Glu Gln  Leu Ser Ala Pro Lys  Lys Asp Val 
    1310                 1315                 1320             


Lys Gln  Pro Glu Glu Leu Pro  Pro Ile Xaa Xaa Xaa  Xaa Xaa Ser 
    1325                 1330                 1335             


Xaa Xaa  Pro Ala Xaa Asn Xaa  Xaa Cys Xaa Ala Xaa  Val Pro Pro 
    1340                 1345                 1350             


Gln Pro  Gln Tyr Ser Tyr His  Asp Ile Asn Val Tyr  Ser Leu Ala 
    1355                 1360                 1365             


Gly Leu  Ala Pro His Ile Xaa  Leu Asn Pro Xaa Ile  Pro Leu Phe 
    1370                 1375                 1380             


Gln Ala  His Pro Gln Leu Lys  Gln Cys Val Arg Gln  Ala Ile Glu 
    1385                 1390                 1395             


Arg Ala  Val Gln Glu Leu Val  His Pro Val Val Asp  Arg Ser Ile 
    1400                 1405                 1410             


Lys Ile  Ala Met Xaa Xaa Cys  Glu Gln Ile Val Arg  Lys Asp Phe 
    1415                 1420                 1425             


Ala Leu  Asp Ser Glu Glu Ser  Arg Met Arg Ile Ala  Ala His His 
    1430                 1435                 1440             


Met Met  Arg Asn Leu Xaa Ala  Gly Met Ala Met Ile  Xaa Cys Arg 
    1445                 1450                 1455             


Glu Pro  Leu Leu Met Ser Ile  Ser Xaa Asn Leu Lys  Asn Ser Phe 
    1460                 1465                 1470             


Ala Ser  Ala Leu Arg Val Ser  Trp Leu Phe Pro Trp  Tyr Arg Tyr 
    1475                 1480                 1485             


Lys Xaa  Tyr Tyr Cys Leu Ser  Val Ile Ile Phe Phe  Phe Val Tyr 
    1490                 1495                 1500             


Ile Trp  His Trp Ala Leu Pro  Leu Ile Leu Asn Asn  His His Ile 
    1505                 1510                 1515             


Cys Leu  Met Ser Ser Ile Ile  Leu Asp Cys Asn Ser  Val Arg Gln 
    1520                 1525                 1530             


Ser Ile  Met Ser Val Cys Phe  Phe Phe Phe Leu Leu  Tyr Ser Gln 
    1535                 1540                 1545             


His Asp  Val 
    1550     


<210> 6508
<211> 2150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1107)..(1107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1173)..(1173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1208)..(1208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1328)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1338)..(1338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1340)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1343)..(1343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1374)..(1374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1413)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1444)..(1444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1451)..(1451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1462)..(1462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1474)..(1474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1505)..(1505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1520)..(1520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1580)..(1580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1587)..(1587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1600)..(1600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1612)..(1612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1624)..(1624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1668)..(1668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1706)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1775)..(1775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1782)..(1782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1785)..(1785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1868)..(1868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1886)..(1886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1891)..(1891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1898)..(1898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1921)..(1921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1949)..(1949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1951)..(1951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1953)..(1953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2005)..(2005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2010)..(2010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2012)..(2012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2017)..(2017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2024)..(2024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2050)..(2050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2080)..(2080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2090)..(2090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2142)..(2142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2149)..(2149)
<223> Selenocysteine

<400> 6508
Met Asn Leu Asp Ser Leu Ser Leu Ala Leu Ser Gln Ile Ser Tyr Leu 
1               5                   10                  15      


Val Asp Asn Leu Xaa Lys Lys Asn Tyr Arg Ala Ser Gln Gln Glu Ile 
            20                  25                  30          


Gln His Ile Val Asn Arg His Gly Pro Glu Ala Asp Arg His Leu Leu 
        35                  40                  45              


Arg Cys Leu Phe Ser His Val Asp Phe Ser Gly Asp Gly Lys Ser Ser 
    50                  55                  60                  


Gly Lys Asp Phe His Gln Xaa Gln Phe Leu Ile Gln Glu Cys Ala Leu 
65                  70                  75                  80  


Leu Ile Xaa Lys Pro Asn Phe Ile Ser Xaa Leu Ser Tyr Ala Ile Asp 
                85                  90                  95      


Asn Pro Leu His Tyr Gln Lys Ser Leu Lys Pro Ala Pro His Leu Phe 
            100                 105                 110         


Ala Gln Leu Ser Lys Val Leu Lys Leu Ser Lys Val Gln Glu Val Ile 
        115                 120                 125             


Phe Gly Leu Ala Leu Leu Asn Ser Ser Ser Ser Asp Leu Arg Gly Phe 
    130                 135                 140                 


Ala Ala Gln Phe Ile Lys Gln Lys Leu Pro Asp Leu Leu Arg Ser Tyr 
145                 150                 155                 160 


Ile Asp Ala Asp Val Ser Gly Asn Gln Glu Gly Gly Phe Gln Asp Ile 
                165                 170                 175     


Ala Ile Glu Val Leu His Leu Leu Leu Ser His Leu Leu Phe Gly Gln 
            180                 185                 190         


Lys Gly Ala Phe Gly Val Gly Gln Glu Gln Ile Asp Ala Phe Leu Lys 
        195                 200                 205             


Xaa Leu Arg Arg Asp Phe Pro Gln Glu Arg Cys Pro Val Val Leu Ala 
    210                 215                 220                 


Pro Leu Leu Tyr Pro Glu Lys Arg Asp Ile Leu Met Asp Arg Ile Leu 
225                 230                 235                 240 


Pro Asp Ser Gly Gly Val Ala Lys Xaa Met Met Glu Ser Ser Leu Ala 
                245                 250                 255     


Asp Phe Met Gln Glu Val Gly Tyr Gly Phe Cys Ala Ser Ile Glu Glu 
            260                 265                 270         


Cys Arg Asn Ile Ile Val Gln Phe Gly Val Arg Glu Val Xaa Ala Ala 
        275                 280                 285             


Gln Val Ala Arg Val Leu Gly Met Met Ala Arg Xaa His Ser Gly Leu 
    290                 295                 300                 


Xaa Asp Gly Ile Pro Leu Gln Ser Ile Ser Ala Pro Gly Ser Gly Ile 
305                 310                 315                 320 


Trp Ser Asp Gly Lys Asp Lys Ser Asp Gly Ala Gln Ala His Xaa Trp 
                325                 330                 335     


Asn Val Glu Val Leu Ile Asp Val Leu Lys Glu Leu Asn Pro Ser Leu 
            340                 345                 350         


Asn Phe Lys Glu Val Xaa Tyr Glu Leu Asp His Pro Gly Phe Gln Ile 
        355                 360                 365             


Arg Asp Ser Lys Gly Leu His Asn Val Val Tyr Gly Ile Gln Arg Gly 
    370                 375                 380                 


Leu Gly Met Glu Val Phe Pro Val Asp Leu Ile Tyr Arg Pro Trp Lys 
385                 390                 395                 400 


His Ala Glu Gly Gln Leu Ser Phe Ile Gln His Ser Leu Ile Asn Pro 
                405                 410                 415     


Glu Ile Phe Cys Phe Ala Asp Tyr Pro Cys His Xaa Val Ala Xaa Asp 
            420                 425                 430         


Ile Leu Lys Ala Pro Pro Glu Asp Asp Asn Arg Glu Ile Ala Xaa Trp 
        435                 440                 445             


Lys Ser Leu Asp Leu Ile Glu Ser Leu Leu Arg Leu Ala Glu Val Gly 
    450                 455                 460                 


Gln Tyr Glu Gln Val Lys Gln Leu Phe Ser Phe Pro Ile Lys His Cys 
465                 470                 475                 480 


Pro Asp Met Leu Val Leu Ala Leu Leu Gln Ile Asn Xaa Ser Trp His 
                485                 490                 495     


Xaa Leu Arg His Glu Leu Ile Ser Xaa Leu Met Pro Ile Phe Leu Gly 
            500                 505                 510         


Asn His Pro Asn Ser Ala Ile Ile Leu His Tyr Ala Trp His Gly Gln 
        515                 520                 525             


Gly Gln Ser Pro Ser Ile Arg Gln Leu Ile Met His Ala Met Ala Glu 
    530                 535                 540                 


Trp Tyr Met Arg Gly Glu Gln Tyr Asp Gln Ala Lys Leu Ser Arg Ile 
545                 550                 555                 560 


Leu Asp Val Ala Gln Asp Leu Lys Ala Leu Ser Met Leu Leu Asn Gly 
                565                 570                 575     


Xaa Pro Phe Ala Phe Val Ile Asp Leu Ala Ala Leu Ala Ser Arg Arg 
            580                 585                 590         


Glu Tyr Leu Lys Leu Asp Lys Trp Leu Xaa Asp Lys Ile Arg Glu His 
        595                 600                 605             


Gly Glu Pro Phe Ile Gln Ala Cys Met Xaa Phe Leu Lys Arg Arg Cys 
    610                 615                 620                 


Pro Ser Ile Leu Gly Gly Leu Ala Pro Glu Lys Asp Gln Pro Lys Ser 
625                 630                 635                 640 


Ala Gln Leu Pro Pro Glu Xaa Leu Ala Xaa Met Leu Ala Cys Leu Gln 
                645                 650                 655     


Ala Cys Ala Gly Ser Val Ser Gln Glu Leu Ser Glu Xaa Ile Leu Xaa 
            660                 665                 670         


Met Val Ala Asn Cys Ser Asn Val Met Asn Lys Ala Arg Gln Pro Pro 
        675                 680                 685             


Pro Gly Val Met Pro Lys Gly Arg Pro Pro Ser Ala Ser Ser Leu Asp 
    690                 695                 700                 


Ala Ile Ser Pro Val Gln Ile Asp Pro Leu Ala Gly Met Xaa Ser Leu 
705                 710                 715                 720 


Ser Ile Gly Gly Ser Ala Ala Pro His Xaa Gln Ser Met Gln Gly Phe 
                725                 730                 735     


Pro Pro Asn Leu Gly Ser Ala Phe Ser Xaa Pro Gln Ser Pro Ala Lys 
            740                 745                 750         


Ala Phe Pro Pro Leu Ser Xaa Pro Asn Gln Xaa Xaa Ala Phe Ser Gly 
        755                 760                 765             


Ile Gly Gly Leu Ser Ser Gln Leu Pro Val Gly Gly Leu Gly Xaa Gly 
    770                 775                 780                 


Ser Leu Xaa Gly Ile Gly Xaa Gly Ala Leu Gly Leu Pro Ala Val Asn 
785                 790                 795                 800 


Asn Asp Pro Phe Val Gln Arg Lys Leu Gly Xaa Ser Gly Leu Asn Gln 
                805                 810                 815     


Pro Xaa Phe Gln Gln Xaa Asp Leu Ser Gln Val Trp Pro Glu Ala Asn 
            820                 825                 830         


Gln His Phe Ser Lys Glu Ile Asp Asp Glu Ala Asn Ser Tyr Phe Gln 
        835                 840                 845             


Arg Ile Tyr Asn His Pro Pro His Pro Xaa Met Ser Val Asp Glu Val 
    850                 855                 860                 


Leu Glu Met Leu Gln Arg Phe Lys Asp Ser Xaa Ile Lys Arg Glu Arg 
865                 870                 875                 880 


Glu Val Phe Asn Cys Met Leu Arg Asn Leu Phe Glu Glu Tyr Arg Phe 
                885                 890                 895     


Phe Pro Gln Tyr Pro Asp Lys Glu Leu His Ile Xaa Ala Cys Leu Phe 
            900                 905                 910         


Gly Gly Ile Ile Glu Lys Gly Leu Val Xaa Tyr Met Ala Leu Gly Leu 
        915                 920                 925             


Ala Leu Arg Tyr Val Leu Glu Ala Leu Arg Lys Pro Phe Gly Ser Lys 
    930                 935                 940                 


Met Tyr Tyr Phe Gly Ile Ala Ala Leu Asp Arg Phe Lys Asn Arg Leu 
945                 950                 955                 960 


Lys Asp Tyr Pro Gln Tyr Cys Gln His Leu Ala Ser Ile Ser His Phe 
                965                 970                 975     


Met Gln Phe Pro His His Leu Gln Glu Tyr Ile Glu Tyr Gly Gln Gln 
            980                 985                 990         


Ser Arg Asp Pro Pro Val Lys Met  Gln Gly Ser Ile Xaa  Xaa Pro Gly 
        995                 1000                 1005             


Ser Ile  Ala Leu Ala Gln Ala  Gln Ala Gln Ala Gln  Val Pro Ala 
    1010                 1015                 1020             


Lys Ala  Pro Leu Ala Gly Gln  Val Ser Xaa Met Val  Xaa Xaa Ser 
    1025                 1030                 1035             


Xaa Xaa  Xaa Xaa Val Ala Lys  Xaa Val Xaa Val Xaa  Arg Pro Xaa 
    1040                 1045                 1050             


Gly Val  Ser Phe Lys Lys Asp  Val Pro Pro Ser Ile  Asn Xaa Xaa 
    1055                 1060                 1065             


Asn Ile  Asp Xaa Leu Leu Val  Ala Xaa Asp Gln Xaa  Glu Arg Ile 
    1070                 1075                 1080             


Val Glu  Pro Pro Glu Asn Ile  Gln Glu Lys Ile Ala  Phe Ile Phe 
    1085                 1090                 1095             


Asn Asn  Leu Ser Gln Ser Asn  Met Xaa Gln Lys Val  Glu Glu Leu 
    1100                 1105                 1110             


Lys Glu  Xaa Val Lys Glu Glu  Phe Met Pro Trp Val  Ser Gln Tyr 
    1115                 1120                 1125             


Leu Val  Met Lys Arg Val Ser  Ile Glu Pro Asn Phe  His Ser Leu 
    1130                 1135                 1140             


Tyr Ser  Asn Phe Leu Asp Xaa  Leu Lys Asn Pro Glu  Phe Asn Lys 
    1145                 1150                 1155             


Met Val  Leu Asn Glu Xaa Tyr  Arg Asn Ile Lys Val  Leu Leu Xaa 
    1160                 1165                 1170             


Ser Asp  Lys Ala Ala Ala Asn  Phe Ser Asp Arg Ser  Leu Leu Lys 
    1175                 1180                 1185             


Asn Leu  Gly His Trp Leu Gly  Met Ile Xaa Leu Ala  Lys Asn Lys 
    1190                 1195                 1200             


Pro Ile  Leu His Xaa Asp Leu  Asp Val Lys Ser Leu  Leu Leu Glu 
    1205                 1210                 1215             


Ala Tyr  Val Lys Gly Gln Gln  Glu Leu Leu Tyr Val  Val Pro Phe 
    1220                 1225                 1230             


Val Ala  Lys Val Leu Glu Ser  Ser Ile Arg Ser Val  Val Phe Arg 
    1235                 1240                 1245             


Pro Pro  Asn Pro Trp Xaa Met  Ala Ile Met Asn Val  Leu Ala Glu 
    1250                 1255                 1260             


Leu His  Gln Glu His Asp Leu  Lys Leu Asn Leu Lys  Phe Glu Ile 
    1265                 1270                 1275             


Glu Val  Leu Cys Lys Asn Leu  Ala Leu Asp Ile Asn  Glu Leu Lys 
    1280                 1285                 1290             


Pro Gly  Asn Leu Leu Lys Asp  Lys Asp Arg Leu Lys  Asn Leu Asp 
    1295                 1300                 1305             


Glu Gln  Leu Ser Ala Pro Lys  Lys Asp Val Lys Gln  Pro Glu Glu 
    1310                 1315                 1320             


Leu Pro  Pro Ile Xaa Xaa Xaa  Xaa Xaa Ser Xaa Xaa  Pro Ala Xaa 
    1325                 1330                 1335             


Asn Xaa  Xaa Cys Xaa Ala Xaa  Val Pro Pro Gln Pro  Gln Tyr Ser 
    1340                 1345                 1350             


Tyr His  Asp Ile Asn Val Tyr  Ser Leu Ala Gly Leu  Ala Pro His 
    1355                 1360                 1365             


Ile Xaa  Leu Asn Pro Xaa Ile  Pro Leu Phe Gln Ala  His Pro Gln 
    1370                 1375                 1380             


Leu Lys  Gln Cys Val Arg Gln  Ala Ile Glu Arg Ala  Val Gln Glu 
    1385                 1390                 1395             


Leu Val  His Pro Val Val Asp  Arg Ser Ile Lys Ile  Ala Met Xaa 
    1400                 1405                 1410             


Xaa Cys  Glu Gln Ile Val Arg  Lys Asp Phe Ala Leu  Asp Ser Glu 
    1415                 1420                 1425             


Glu Ser  Arg Met Arg Ile Ala  Ala His His Met Met  Arg Asn Leu 
    1430                 1435                 1440             


Xaa Ala  Gly Met Ala Met Ile  Xaa Cys Arg Glu Pro  Leu Leu Met 
    1445                 1450                 1455             


Ser Ile  Ser Xaa Asn Leu Lys  Asn Ser Phe Ala Ser  Ala Leu Arg 
    1460                 1465                 1470             


Xaa Ala  Ser Pro Gln Gln Arg  Glu Met Met Asp Gln  Ala Ala Ala 
    1475                 1480                 1485             


Gln Leu  Ala Gln Asp Asn Cys  Glu Leu Ala Cys Cys  Phe Ile Gln 
    1490                 1495                 1500             


Lys Xaa  Ala Val Glu Lys Ala  Gly Pro Glu Met Asp  Lys Arg Leu 
    1505                 1510                 1515             


Ala Xaa  Glu Phe Glu Leu Arg  Lys His Ala Arg Gln  Glu Gly Arg 
    1520                 1525                 1530             


Arg Tyr  Cys Asp Pro Val Val  Leu Xaa Tyr Gln Ala  Glu Arg Met 
    1535                 1540                 1545             


Pro Glu  Gln Ile Arg Leu Lys  Val Gly Gly Val Asp  Pro Lys Gln 
    1550                 1555                 1560             


Leu Ala  Val Tyr Glu Glu Phe  Ala Arg Asn Val Pro  Gly Phe Leu 
    1565                 1570                 1575             


Pro Xaa  Asn Asp Leu Ser Gln  Pro Xaa Gly Phe Leu  Ala Gln Pro 
    1580                 1585                 1590             


Met Lys  Gln Ala Trp Ala Xaa  Asp Asp Val Ala Gln  Ile Tyr Asp 
    1595                 1600                 1605             


Lys Cys  Ile Xaa Glu Leu Glu  Gln His Leu His Ala  Ile Pro Pro 
    1610                 1615                 1620             


Xaa Leu  Ala Met Asn Pro Gln  Ala Gln Ala Leu Arg  Ser Leu Leu 
    1625                 1630                 1635             


Glu Val  Val Val Leu Ser Arg  Asn Ser Arg Asp Ala  Ile Ala Ala 
    1640                 1645                 1650             


Leu Gly  Leu Leu Gln Lys Ala  Val Glu Gly Leu Leu  Asp Ala Xaa 
    1655                 1660                 1665             


Ser Gly  Ala Asp Ala Asp Leu  Leu Leu Arg Tyr Arg  Glu Cys His 
    1670                 1675                 1680             


Leu Leu  Val Leu Lys Ala Leu  Gln Asp Gly Arg Ala  Tyr Gly Ser 
    1685                 1690                 1695             


Pro Trp  Cys Asn Lys Gln Ile  Xaa Arg Cys Leu Ile  Glu Cys Arg 
    1700                 1705                 1710             


Asp Glu  Tyr Lys Tyr Asn Val  Glu Ala Val Glu Leu  Leu Ile Arg 
    1715                 1720                 1725             


Asn His  Leu Val Asn Met Gln  Gln Tyr Asp Leu His  Leu Ala Gln 
    1730                 1735                 1740             


Ser Met  Glu Asn Gly Leu Asn  Tyr Met Ala Val Ala  Phe Ala Met 
    1745                 1750                 1755             


Gln Leu  Val Lys Ile Leu Leu  Val Asp Glu Arg Ser  Val Ala His 
    1760                 1765                 1770             


Val Xaa  Glu Ala Asp Leu Phe  His Xaa Ile Glu Xaa  Leu Met Arg 
    1775                 1780                 1785             


Ile Asn  Ala His Ser Arg Gly  Asn Ala Pro Glu Gly  Leu Pro Gln 
    1790                 1795                 1800             


Leu Met  Glu Val Val Arg Ser  Asn Tyr Glu Ala Met  Ile Asp Arg 
    1805                 1810                 1815             


Ala His  Gly Gly Pro Asn Phe  Met Met His Ser Gly  Ile Ser Gln 
    1820                 1825                 1830             


Ala Ser  Glu Tyr Asp Asp Pro  Pro Gly Leu Arg Glu  Lys Ala Glu 
    1835                 1840                 1845             


Tyr Leu  Leu Arg Glu Trp Val  Asn Leu Tyr His Ser  Ala Ala Ala 
    1850                 1855                 1860             


Gly Arg  Asp Ser Xaa Lys Ala  Phe Ser Ala Phe Val  Gly Gln Met 
    1865                 1870                 1875             


His Gln  Gln Gly Ile Leu Lys  Xaa Asp Asp Leu Ile  Xaa Arg Phe 
    1880                 1885                 1890             


Phe Arg  Leu Cys Xaa Glu Met  Cys Val Glu Ile Ser  Tyr Arg Ala 
    1895                 1900                 1905             


Gln Ala  Glu Gln Gln His Asn  Pro Ala Ala Asn Pro  Xaa Met Ile 
    1910                 1915                 1920             


Arg Ala  Lys Cys Tyr His Asn  Leu Asp Ala Phe Val  Arg Leu Ile 
    1925                 1930                 1935             


Ala Leu  Leu Val Lys His Ser  Gly Glu Ala Xaa Asn  Xaa Val Xaa 
    1940                 1945                 1950             


Lys Ile  Asn Leu Leu Asn Lys  Val Leu Gly Ile Val  Val Gly Val 
    1955                 1960                 1965             


Leu Leu  Gln Asp His Asp Val  Arg Gln Ser Glu Phe  Gln Gln Leu 
    1970                 1975                 1980             


Pro Tyr  His Arg Ile Phe Ile  Met Leu Leu Leu Glu  Leu Asn Ala 
    1985                 1990                 1995             


Pro Glu  His Val Leu Glu Xaa  Ile Asn Phe Gln Xaa  Leu Xaa Ala 
    2000                 2005                 2010             


Phe Cys  Asn Xaa Phe His Ile  Leu Arg Pro Xaa Lys  Ala Pro Gly 
    2015                 2020                 2025             


Phe Val  Tyr Ala Trp Leu Glu  Leu Ile Ser His Arg  Ile Phe Ile 
    2030                 2035                 2040             


Ala Arg  Met Leu Ala His Xaa  Pro Gln Gln Lys Gly  Trp Pro Met 
    2045                 2050                 2055             


Tyr Ala  Gln Leu Leu Ile Asp  Leu Phe Lys Tyr Leu  Ala Pro Phe 
    2060                 2065                 2070             


Leu Arg  Asn Val Glu Leu Xaa  Lys Pro Met Gln Ile  Leu Tyr Lys 
    2075                 2080                 2085             


Gly Xaa  Leu Arg Val Leu Leu  Val Leu Leu His Asp  Phe Pro Glu 
    2090                 2095                 2100             


Phe Leu  Cys Asp Tyr His Tyr  Gly Phe Cys Asp Val  Ile Pro Pro 
    2105                 2110                 2115             


Asn Cys  Ile Gln Leu Arg Asn  Leu Ile Leu Ser Ala  Phe Pro Arg 
    2120                 2125                 2130             


Asn Met  Arg Leu Pro Asp Pro  Phe Xaa Pro Asn Leu  Lys Ser Leu 
    2135                 2140                 2145             


Xaa Leu  
    2150 


<210> 6509
<211> 2371
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1005)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1107)..(1107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1150)..(1150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1173)..(1173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1208)..(1208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1328)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1338)..(1338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1340)..(1341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1343)..(1343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1374)..(1374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1413)..(1414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1444)..(1444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1451)..(1451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1462)..(1462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1474)..(1474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1505)..(1505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1520)..(1520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1580)..(1580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1587)..(1587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1600)..(1600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1612)..(1612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1624)..(1624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1668)..(1668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1706)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1775)..(1775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1782)..(1782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1785)..(1785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1868)..(1868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1886)..(1886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1891)..(1891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1898)..(1898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1921)..(1921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1949)..(1949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1951)..(1951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1953)..(1953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2005)..(2005)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2010)..(2010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2012)..(2012)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2017)..(2017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2024)..(2024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2050)..(2050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2080)..(2080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2090)..(2090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2142)..(2142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2161)..(2161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2164)..(2164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2181)..(2181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2186)..(2186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2219)..(2219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2231)..(2231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2236)..(2236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2238)..(2238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2255)..(2255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2276)..(2276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2282)..(2282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2292)..(2292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2300)..(2300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2320)..(2320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2368)..(2368)
<223> Selenocysteine

<400> 6509
Met Asn Leu Asp Ser Leu Ser Leu Ala Leu Ser Gln Ile Ser Tyr Leu 
1               5                   10                  15      


Val Asp Asn Leu Xaa Lys Lys Asn Tyr Arg Ala Ser Gln Gln Glu Ile 
            20                  25                  30          


Gln His Ile Val Asn Arg His Gly Pro Glu Ala Asp Arg His Leu Leu 
        35                  40                  45              


Arg Cys Leu Phe Ser His Val Asp Phe Ser Gly Asp Gly Lys Ser Ser 
    50                  55                  60                  


Gly Lys Asp Phe His Gln Xaa Gln Phe Leu Ile Gln Glu Cys Ala Leu 
65                  70                  75                  80  


Leu Ile Xaa Lys Pro Asn Phe Ile Ser Xaa Leu Ser Tyr Ala Ile Asp 
                85                  90                  95      


Asn Pro Leu His Tyr Gln Lys Ser Leu Lys Pro Ala Pro His Leu Phe 
            100                 105                 110         


Ala Gln Leu Ser Lys Val Leu Lys Leu Ser Lys Val Gln Glu Val Ile 
        115                 120                 125             


Phe Gly Leu Ala Leu Leu Asn Ser Ser Ser Ser Asp Leu Arg Gly Phe 
    130                 135                 140                 


Ala Ala Gln Phe Ile Lys Gln Lys Leu Pro Asp Leu Leu Arg Ser Tyr 
145                 150                 155                 160 


Ile Asp Ala Asp Val Ser Gly Asn Gln Glu Gly Gly Phe Gln Asp Ile 
                165                 170                 175     


Ala Ile Glu Val Leu His Leu Leu Leu Ser His Leu Leu Phe Gly Gln 
            180                 185                 190         


Lys Gly Ala Phe Gly Val Gly Gln Glu Gln Ile Asp Ala Phe Leu Lys 
        195                 200                 205             


Xaa Leu Arg Arg Asp Phe Pro Gln Glu Arg Cys Pro Val Val Leu Ala 
    210                 215                 220                 


Pro Leu Leu Tyr Pro Glu Lys Arg Asp Ile Leu Met Asp Arg Ile Leu 
225                 230                 235                 240 


Pro Asp Ser Gly Gly Val Ala Lys Xaa Met Met Glu Ser Ser Leu Ala 
                245                 250                 255     


Asp Phe Met Gln Glu Val Gly Tyr Gly Phe Cys Ala Ser Ile Glu Glu 
            260                 265                 270         


Cys Arg Asn Ile Ile Val Gln Phe Gly Val Arg Glu Val Xaa Ala Ala 
        275                 280                 285             


Gln Val Ala Arg Val Leu Gly Met Met Ala Arg Xaa His Ser Gly Leu 
    290                 295                 300                 


Xaa Asp Gly Ile Pro Leu Gln Ser Ile Ser Ala Pro Gly Ser Gly Ile 
305                 310                 315                 320 


Trp Ser Asp Gly Lys Asp Lys Ser Asp Gly Ala Gln Ala His Xaa Trp 
                325                 330                 335     


Asn Val Glu Val Leu Ile Asp Val Leu Lys Glu Leu Asn Pro Ser Leu 
            340                 345                 350         


Asn Phe Lys Glu Val Xaa Tyr Glu Leu Asp His Pro Gly Phe Gln Ile 
        355                 360                 365             


Arg Asp Ser Lys Gly Leu His Asn Val Val Tyr Gly Ile Gln Arg Gly 
    370                 375                 380                 


Leu Gly Met Glu Val Phe Pro Val Asp Leu Ile Tyr Arg Pro Trp Lys 
385                 390                 395                 400 


His Ala Glu Gly Gln Leu Ser Phe Ile Gln His Ser Leu Ile Asn Pro 
                405                 410                 415     


Glu Ile Phe Cys Phe Ala Asp Tyr Pro Cys His Xaa Val Ala Xaa Asp 
            420                 425                 430         


Ile Leu Lys Ala Pro Pro Glu Asp Asp Asn Arg Glu Ile Ala Xaa Trp 
        435                 440                 445             


Lys Ser Leu Asp Leu Ile Glu Ser Leu Leu Arg Leu Ala Glu Val Gly 
    450                 455                 460                 


Gln Tyr Glu Gln Val Lys Gln Leu Phe Ser Phe Pro Ile Lys His Cys 
465                 470                 475                 480 


Pro Asp Met Leu Val Leu Ala Leu Leu Gln Ile Asn Xaa Ser Trp His 
                485                 490                 495     


Xaa Leu Arg His Glu Leu Ile Ser Xaa Leu Met Pro Ile Phe Leu Gly 
            500                 505                 510         


Asn His Pro Asn Ser Ala Ile Ile Leu His Tyr Ala Trp His Gly Gln 
        515                 520                 525             


Gly Gln Ser Pro Ser Ile Arg Gln Leu Ile Met His Ala Met Ala Glu 
    530                 535                 540                 


Trp Tyr Met Arg Gly Glu Gln Tyr Asp Gln Ala Lys Leu Ser Arg Ile 
545                 550                 555                 560 


Leu Asp Val Ala Gln Asp Leu Lys Ala Leu Ser Met Leu Leu Asn Gly 
                565                 570                 575     


Xaa Pro Phe Ala Phe Val Ile Asp Leu Ala Ala Leu Ala Ser Arg Arg 
            580                 585                 590         


Glu Tyr Leu Lys Leu Asp Lys Trp Leu Xaa Asp Lys Ile Arg Glu His 
        595                 600                 605             


Gly Glu Pro Phe Ile Gln Ala Cys Met Xaa Phe Leu Lys Arg Arg Cys 
    610                 615                 620                 


Pro Ser Ile Leu Gly Gly Leu Ala Pro Glu Lys Asp Gln Pro Lys Ser 
625                 630                 635                 640 


Ala Gln Leu Pro Pro Glu Xaa Leu Ala Xaa Met Leu Ala Cys Leu Gln 
                645                 650                 655     


Ala Cys Ala Gly Ser Val Ser Gln Glu Leu Ser Glu Xaa Ile Leu Xaa 
            660                 665                 670         


Met Val Ala Asn Cys Ser Asn Val Met Asn Lys Ala Arg Gln Pro Pro 
        675                 680                 685             


Pro Gly Val Met Pro Lys Gly Arg Pro Pro Ser Ala Ser Ser Leu Asp 
    690                 695                 700                 


Ala Ile Ser Pro Val Gln Ile Asp Pro Leu Ala Gly Met Xaa Ser Leu 
705                 710                 715                 720 


Ser Ile Gly Gly Ser Ala Ala Pro His Xaa Gln Ser Met Gln Gly Phe 
                725                 730                 735     


Pro Pro Asn Leu Gly Ser Ala Phe Ser Xaa Pro Gln Ser Pro Ala Lys 
            740                 745                 750         


Ala Phe Pro Pro Leu Ser Xaa Pro Asn Gln Xaa Xaa Ala Phe Ser Gly 
        755                 760                 765             


Ile Gly Gly Leu Ser Ser Gln Leu Pro Val Gly Gly Leu Gly Xaa Gly 
    770                 775                 780                 


Ser Leu Xaa Gly Ile Gly Xaa Gly Ala Leu Gly Leu Pro Ala Val Asn 
785                 790                 795                 800 


Asn Asp Pro Phe Val Gln Arg Lys Leu Gly Xaa Ser Gly Leu Asn Gln 
                805                 810                 815     


Pro Xaa Phe Gln Gln Xaa Asp Leu Ser Gln Val Trp Pro Glu Ala Asn 
            820                 825                 830         


Gln His Phe Ser Lys Glu Ile Asp Asp Glu Ala Asn Ser Tyr Phe Gln 
        835                 840                 845             


Arg Ile Tyr Asn His Pro Pro His Pro Xaa Met Ser Val Asp Glu Val 
    850                 855                 860                 


Leu Glu Met Leu Gln Arg Phe Lys Asp Ser Xaa Ile Lys Arg Glu Arg 
865                 870                 875                 880 


Glu Val Phe Asn Cys Met Leu Arg Asn Leu Phe Glu Glu Tyr Arg Phe 
                885                 890                 895     


Phe Pro Gln Tyr Pro Asp Lys Glu Leu His Ile Xaa Ala Cys Leu Phe 
            900                 905                 910         


Gly Gly Ile Ile Glu Lys Gly Leu Val Xaa Tyr Met Ala Leu Gly Leu 
        915                 920                 925             


Ala Leu Arg Tyr Val Leu Glu Ala Leu Arg Lys Pro Phe Gly Ser Lys 
    930                 935                 940                 


Met Tyr Tyr Phe Gly Ile Ala Ala Leu Asp Arg Phe Lys Asn Arg Leu 
945                 950                 955                 960 


Lys Asp Tyr Pro Gln Tyr Cys Gln His Leu Ala Ser Ile Ser His Phe 
                965                 970                 975     


Met Gln Phe Pro His His Leu Gln Glu Tyr Ile Glu Tyr Gly Gln Gln 
            980                 985                 990         


Ser Arg Asp Pro Pro Val Lys Met  Gln Gly Ser Ile Xaa  Xaa Pro Gly 
        995                 1000                 1005             


Ser Ile  Ala Leu Ala Gln Ala  Gln Ala Gln Ala Gln  Val Pro Ala 
    1010                 1015                 1020             


Lys Ala  Pro Leu Ala Gly Gln  Val Ser Xaa Met Val  Xaa Xaa Ser 
    1025                 1030                 1035             


Xaa Xaa  Xaa Xaa Val Ala Lys  Xaa Val Xaa Val Xaa  Arg Pro Xaa 
    1040                 1045                 1050             


Gly Val  Ser Phe Lys Lys Asp  Val Pro Pro Ser Ile  Asn Xaa Xaa 
    1055                 1060                 1065             


Asn Ile  Asp Xaa Leu Leu Val  Ala Xaa Asp Gln Xaa  Glu Arg Ile 
    1070                 1075                 1080             


Val Glu  Pro Pro Glu Asn Ile  Gln Glu Lys Ile Ala  Phe Ile Phe 
    1085                 1090                 1095             


Asn Asn  Leu Ser Gln Ser Asn  Met Xaa Gln Lys Val  Glu Glu Leu 
    1100                 1105                 1110             


Lys Glu  Xaa Val Lys Glu Glu  Phe Met Pro Trp Val  Ser Gln Tyr 
    1115                 1120                 1125             


Leu Val  Met Lys Arg Val Ser  Ile Glu Pro Asn Phe  His Ser Leu 
    1130                 1135                 1140             


Tyr Ser  Asn Phe Leu Asp Xaa  Leu Lys Asn Pro Glu  Phe Asn Lys 
    1145                 1150                 1155             


Met Val  Leu Asn Glu Xaa Tyr  Arg Asn Ile Lys Val  Leu Leu Xaa 
    1160                 1165                 1170             


Ser Asp  Lys Ala Ala Ala Asn  Phe Ser Asp Arg Ser  Leu Leu Lys 
    1175                 1180                 1185             


Asn Leu  Gly His Trp Leu Gly  Met Ile Xaa Leu Ala  Lys Asn Lys 
    1190                 1195                 1200             


Pro Ile  Leu His Xaa Asp Leu  Asp Val Lys Ser Leu  Leu Leu Glu 
    1205                 1210                 1215             


Ala Tyr  Val Lys Gly Gln Gln  Glu Leu Leu Tyr Val  Val Pro Phe 
    1220                 1225                 1230             


Val Ala  Lys Val Leu Glu Ser  Ser Ile Arg Ser Val  Val Phe Arg 
    1235                 1240                 1245             


Pro Pro  Asn Pro Trp Xaa Met  Ala Ile Met Asn Val  Leu Ala Glu 
    1250                 1255                 1260             


Leu His  Gln Glu His Asp Leu  Lys Leu Asn Leu Lys  Phe Glu Ile 
    1265                 1270                 1275             


Glu Val  Leu Cys Lys Asn Leu  Ala Leu Asp Ile Asn  Glu Leu Lys 
    1280                 1285                 1290             


Pro Gly  Asn Leu Leu Lys Asp  Lys Asp Arg Leu Lys  Asn Leu Asp 
    1295                 1300                 1305             


Glu Gln  Leu Ser Ala Pro Lys  Lys Asp Val Lys Gln  Pro Glu Glu 
    1310                 1315                 1320             


Leu Pro  Pro Ile Xaa Xaa Xaa  Xaa Xaa Ser Xaa Xaa  Pro Ala Xaa 
    1325                 1330                 1335             


Asn Xaa  Xaa Cys Xaa Ala Xaa  Val Pro Pro Gln Pro  Gln Tyr Ser 
    1340                 1345                 1350             


Tyr His  Asp Ile Asn Val Tyr  Ser Leu Ala Gly Leu  Ala Pro His 
    1355                 1360                 1365             


Ile Xaa  Leu Asn Pro Xaa Ile  Pro Leu Phe Gln Ala  His Pro Gln 
    1370                 1375                 1380             


Leu Lys  Gln Cys Val Arg Gln  Ala Ile Glu Arg Ala  Val Gln Glu 
    1385                 1390                 1395             


Leu Val  His Pro Val Val Asp  Arg Ser Ile Lys Ile  Ala Met Xaa 
    1400                 1405                 1410             


Xaa Cys  Glu Gln Ile Val Arg  Lys Asp Phe Ala Leu  Asp Ser Glu 
    1415                 1420                 1425             


Glu Ser  Arg Met Arg Ile Ala  Ala His His Met Met  Arg Asn Leu 
    1430                 1435                 1440             


Xaa Ala  Gly Met Ala Met Ile  Xaa Cys Arg Glu Pro  Leu Leu Met 
    1445                 1450                 1455             


Ser Ile  Ser Xaa Asn Leu Lys  Asn Ser Phe Ala Ser  Ala Leu Arg 
    1460                 1465                 1470             


Xaa Ala  Ser Pro Gln Gln Arg  Glu Met Met Asp Gln  Ala Ala Ala 
    1475                 1480                 1485             


Gln Leu  Ala Gln Asp Asn Cys  Glu Leu Ala Cys Cys  Phe Ile Gln 
    1490                 1495                 1500             


Lys Xaa  Ala Val Glu Lys Ala  Gly Pro Glu Met Asp  Lys Arg Leu 
    1505                 1510                 1515             


Ala Xaa  Glu Phe Glu Leu Arg  Lys His Ala Arg Gln  Glu Gly Arg 
    1520                 1525                 1530             


Arg Tyr  Cys Asp Pro Val Val  Leu Xaa Tyr Gln Ala  Glu Arg Met 
    1535                 1540                 1545             


Pro Glu  Gln Ile Arg Leu Lys  Val Gly Gly Val Asp  Pro Lys Gln 
    1550                 1555                 1560             


Leu Ala  Val Tyr Glu Glu Phe  Ala Arg Asn Val Pro  Gly Phe Leu 
    1565                 1570                 1575             


Pro Xaa  Asn Asp Leu Ser Gln  Pro Xaa Gly Phe Leu  Ala Gln Pro 
    1580                 1585                 1590             


Met Lys  Gln Ala Trp Ala Xaa  Asp Asp Val Ala Gln  Ile Tyr Asp 
    1595                 1600                 1605             


Lys Cys  Ile Xaa Glu Leu Glu  Gln His Leu His Ala  Ile Pro Pro 
    1610                 1615                 1620             


Xaa Leu  Ala Met Asn Pro Gln  Ala Gln Ala Leu Arg  Ser Leu Leu 
    1625                 1630                 1635             


Glu Val  Val Val Leu Ser Arg  Asn Ser Arg Asp Ala  Ile Ala Ala 
    1640                 1645                 1650             


Leu Gly  Leu Leu Gln Lys Ala  Val Glu Gly Leu Leu  Asp Ala Xaa 
    1655                 1660                 1665             


Ser Gly  Ala Asp Ala Asp Leu  Leu Leu Arg Tyr Arg  Glu Cys His 
    1670                 1675                 1680             


Leu Leu  Val Leu Lys Ala Leu  Gln Asp Gly Arg Ala  Tyr Gly Ser 
    1685                 1690                 1695             


Pro Trp  Cys Asn Lys Gln Ile  Xaa Arg Cys Leu Ile  Glu Cys Arg 
    1700                 1705                 1710             


Asp Glu  Tyr Lys Tyr Asn Val  Glu Ala Val Glu Leu  Leu Ile Arg 
    1715                 1720                 1725             


Asn His  Leu Val Asn Met Gln  Gln Tyr Asp Leu His  Leu Ala Gln 
    1730                 1735                 1740             


Ser Met  Glu Asn Gly Leu Asn  Tyr Met Ala Val Ala  Phe Ala Met 
    1745                 1750                 1755             


Gln Leu  Val Lys Ile Leu Leu  Val Asp Glu Arg Ser  Val Ala His 
    1760                 1765                 1770             


Val Xaa  Glu Ala Asp Leu Phe  His Xaa Ile Glu Xaa  Leu Met Arg 
    1775                 1780                 1785             


Ile Asn  Ala His Ser Arg Gly  Asn Ala Pro Glu Gly  Leu Pro Gln 
    1790                 1795                 1800             


Leu Met  Glu Val Val Arg Ser  Asn Tyr Glu Ala Met  Ile Asp Arg 
    1805                 1810                 1815             


Ala His  Gly Gly Pro Asn Phe  Met Met His Ser Gly  Ile Ser Gln 
    1820                 1825                 1830             


Ala Ser  Glu Tyr Asp Asp Pro  Pro Gly Leu Arg Glu  Lys Ala Glu 
    1835                 1840                 1845             


Tyr Leu  Leu Arg Glu Trp Val  Asn Leu Tyr His Ser  Ala Ala Ala 
    1850                 1855                 1860             


Gly Arg  Asp Ser Xaa Lys Ala  Phe Ser Ala Phe Val  Gly Gln Met 
    1865                 1870                 1875             


His Gln  Gln Gly Ile Leu Lys  Xaa Asp Asp Leu Ile  Xaa Arg Phe 
    1880                 1885                 1890             


Phe Arg  Leu Cys Xaa Glu Met  Cys Val Glu Ile Ser  Tyr Arg Ala 
    1895                 1900                 1905             


Gln Ala  Glu Gln Gln His Asn  Pro Ala Ala Asn Pro  Xaa Met Ile 
    1910                 1915                 1920             


Arg Ala  Lys Cys Tyr His Asn  Leu Asp Ala Phe Val  Arg Leu Ile 
    1925                 1930                 1935             


Ala Leu  Leu Val Lys His Ser  Gly Glu Ala Xaa Asn  Xaa Val Xaa 
    1940                 1945                 1950             


Lys Ile  Asn Leu Leu Asn Lys  Val Leu Gly Ile Val  Val Gly Val 
    1955                 1960                 1965             


Leu Leu  Gln Asp His Asp Val  Arg Gln Ser Glu Phe  Gln Gln Leu 
    1970                 1975                 1980             


Pro Tyr  His Arg Ile Phe Ile  Met Leu Leu Leu Glu  Leu Asn Ala 
    1985                 1990                 1995             


Pro Glu  His Val Leu Glu Xaa  Ile Asn Phe Gln Xaa  Leu Xaa Ala 
    2000                 2005                 2010             


Phe Cys  Asn Xaa Phe His Ile  Leu Arg Pro Xaa Lys  Ala Pro Gly 
    2015                 2020                 2025             


Phe Val  Tyr Ala Trp Leu Glu  Leu Ile Ser His Arg  Ile Phe Ile 
    2030                 2035                 2040             


Ala Arg  Met Leu Ala His Xaa  Pro Gln Gln Lys Gly  Trp Pro Met 
    2045                 2050                 2055             


Tyr Ala  Gln Leu Leu Ile Asp  Leu Phe Lys Tyr Leu  Ala Pro Phe 
    2060                 2065                 2070             


Leu Arg  Asn Val Glu Leu Xaa  Lys Pro Met Gln Ile  Leu Tyr Lys 
    2075                 2080                 2085             


Gly Xaa  Leu Arg Val Leu Leu  Val Leu Leu His Asp  Phe Pro Glu 
    2090                 2095                 2100             


Phe Leu  Cys Asp Tyr His Tyr  Gly Phe Cys Asp Val  Ile Pro Pro 
    2105                 2110                 2115             


Asn Cys  Ile Gln Leu Arg Asn  Leu Ile Leu Ser Ala  Phe Pro Arg 
    2120                 2125                 2130             


Asn Met  Arg Leu Pro Asp Pro  Phe Xaa Pro Asn Leu  Lys Val Asp 
    2135                 2140                 2145             


Met Leu  Ser Glu Ile Asn Ile  Ala Pro Arg Ile Leu  Xaa Asn Phe 
    2150                 2155                 2160             


Xaa Gly  Val Met Pro Pro Gln  Phe Lys Lys Asp Leu  Asp Ser Tyr 
    2165                 2170                 2175             


Leu Lys  Xaa Arg Ser Pro Val  Xaa Phe Leu Ser Asp  Leu Arg Ser 
    2180                 2185                 2190             


Asn Leu  Gln Val Ser Asn Glu  Pro Gly Asn Arg Tyr  Asn Leu Gln 
    2195                 2200                 2205             


Leu Ile  Asn Ala Leu Val Leu  Tyr Val Gly Xaa Gln  Ala Ile Ala 
    2210                 2215                 2220             


His Ile  His Asn Lys Gly Ser  Xaa Pro Ser Met Ser  Xaa Ile Xaa 
    2225                 2230                 2235             


His Ser  Ala His Met Asp Ile  Phe Gln Asn Leu Ala  Val Asp Leu 
    2240                 2245                 2250             


Asp Xaa  Glu Gly Arg Tyr Leu  Phe Leu Asn Ala Ile  Ala Asn Gln 
    2255                 2260                 2265             


Leu Arg  Tyr Pro Asn Ser His  Xaa His Tyr Phe Ser  Cys Xaa Met 
    2270                 2275                 2280             


Leu Tyr  Leu Phe Ala Glu Ala  Asn Xaa Glu Ala Ile  Gln Glu Gln 
    2285                 2290                 2295             


Ile Xaa  Arg Val Leu Leu Glu  Arg Leu Ile Val Asn  Arg Pro His 
    2300                 2305                 2310             


Pro Trp  Gly Leu Leu Ile Xaa  Phe Ile Glu Leu Ile  Lys Asn Pro 
    2315                 2320                 2325             


Ala Phe  Lys Phe Trp Asn His  Glu Phe Val His Cys  Ala Pro Glu 
    2330                 2335                 2340             


Ile Glu  Lys Leu Phe Gln Ser  Val Ala Gln Cys Cys  Met Gly Gln 
    2345                 2350                 2355             


Lys Gln  Ala Gln Gln Val Met  Glu Gly Xaa Gly Ala  Ser 
    2360                 2365                 2370     


<210> 6510
<211> 2376
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (763)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1058)..(1058)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1085)..(1085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1213)..(1213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1339)..(1340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1343)..(1343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1348)..(1348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1375)..(1375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1379)..(1379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1418)..(1419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1449)..(1449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1456)..(1456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1467)..(1467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1479)..(1479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1510)..(1510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1525)..(1525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1585)..(1585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1592)..(1592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1605)..(1605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1617)..(1617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1629)..(1629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1673)..(1673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1711)..(1711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1780)..(1780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1787)..(1787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1790)..(1790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1873)..(1873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1891)..(1891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1896)..(1896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1903)..(1903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1926)..(1926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1954)..(1954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1956)..(1956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1958)..(1958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2010)..(2010)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2015)..(2015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2017)..(2017)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2022)..(2022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2029)..(2029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2055)..(2055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2085)..(2085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2095)..(2095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2147)..(2147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2166)..(2166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2169)..(2169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2186)..(2186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2191)..(2191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2224)..(2224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2236)..(2236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2241)..(2241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2243)..(2243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2260)..(2260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2281)..(2281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2287)..(2287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2297)..(2297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2305)..(2305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2325)..(2325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2373)..(2373)
<223> Selenocysteine

<400> 6510
Met Asn Leu Asp Ser Leu Ser Leu Ala Leu Ser Gln Ile Ser Tyr Leu 
1               5                   10                  15      


Val Asp Asn Leu Xaa Lys Lys Asn Tyr Arg Ala Ser Gln Gln Glu Ile 
            20                  25                  30          


Gln His Ile Val Asn Arg His Gly Pro Glu Ala Asp Arg His Leu Leu 
        35                  40                  45              


Arg Cys Leu Phe Ser His Val Asp Phe Ser Gly Asp Gly Lys Ser Ser 
    50                  55                  60                  


Gly Lys Asp Phe His Gln Xaa Gln Phe Leu Ile Gln Glu Cys Ala Leu 
65                  70                  75                  80  


Leu Ile Xaa Lys Pro Asn Phe Ile Ser Xaa Leu Ser Tyr Ala Ile Asp 
                85                  90                  95      


Asn Pro Leu His Tyr Gln Lys Ser Leu Lys Pro Ala Pro His Leu Phe 
            100                 105                 110         


Ala Gln Leu Ser Lys Val Leu Lys Leu Ser Lys Val Gln Glu Val Ile 
        115                 120                 125             


Phe Gly Leu Ala Leu Leu Asn Ser Ser Ser Ser Asp Leu Arg Gly Phe 
    130                 135                 140                 


Ala Ala Gln Phe Ile Lys Gln Lys Leu Pro Asp Leu Leu Arg Ser Tyr 
145                 150                 155                 160 


Ile Asp Ala Asp Val Ser Gly Asn Gln Glu Gly Gly Phe Gln Asp Ile 
                165                 170                 175     


Ala Ile Glu Val Leu His Leu Leu Leu Ser His Leu Leu Phe Gly Gln 
            180                 185                 190         


Lys Gly Ala Phe Gly Val Gly Gln Glu Gln Ile Asp Ala Phe Leu Lys 
        195                 200                 205             


Xaa Leu Arg Arg Asp Phe Pro Gln Glu Arg Cys Pro Val Val Leu Ala 
    210                 215                 220                 


Pro Leu Leu Tyr Pro Glu Lys Arg Asp Ile Leu Met Asp Arg Ile Leu 
225                 230                 235                 240 


Pro Asp Ser Gly Gly Val Ala Lys Xaa Met Met Glu Ser Ser Leu Ala 
                245                 250                 255     


Asp Phe Met Gln Glu Val Gly Tyr Gly Phe Cys Ala Ser Ile Glu Glu 
            260                 265                 270         


Cys Arg Asn Ile Ile Val Gln Phe Gly Val Arg Glu Val Xaa Ala Ala 
        275                 280                 285             


Gln Val Ala Arg Val Leu Gly Met Met Ala Arg Xaa His Ser Gly Leu 
    290                 295                 300                 


Xaa Asp Gly Ile Pro Leu Gln Ser Ile Ser Ala Pro Gly Ser Gly Ile 
305                 310                 315                 320 


Trp Ser Asp Gly Lys Asp Lys Ser Asp Gly Ala Gln Ala His Xaa Trp 
                325                 330                 335     


Asn Val Glu Val Leu Ile Asp Val Leu Lys Glu Leu Asn Pro Ser Leu 
            340                 345                 350         


Asn Phe Lys Glu Val Xaa Tyr Glu Leu Asp His Pro Gly Phe Gln Ile 
        355                 360                 365             


Arg Asp Ser Lys Gly Leu His Asn Val Val Tyr Gly Ile Gln Arg Gly 
    370                 375                 380                 


Leu Gly Met Glu Val Phe Pro Val Asp Leu Ile Tyr Arg Pro Trp Lys 
385                 390                 395                 400 


His Ala Glu Gly Gln Leu Ser Phe Ile Gln His Ser Leu Ile Asn Pro 
                405                 410                 415     


Glu Ile Phe Cys Phe Ala Asp Tyr Pro Cys His Xaa Val Ala Xaa Asp 
            420                 425                 430         


Ile Leu Lys Ala Pro Pro Glu Asp Asp Asn Arg Glu Ile Ala Xaa Trp 
        435                 440                 445             


Lys Ser Leu Asp Leu Ile Glu Ser Leu Leu Arg Leu Ala Glu Val Gly 
    450                 455                 460                 


Gln Tyr Glu Gln Val Lys Gln Leu Phe Ser Phe Pro Ile Lys His Cys 
465                 470                 475                 480 


Pro Asp Met Leu Val Leu Ala Leu Leu Gln Ile Asn Xaa Ser Trp His 
                485                 490                 495     


Xaa Leu Arg His Glu Leu Ile Ser Xaa Leu Met Pro Ile Phe Leu Gly 
            500                 505                 510         


Asn His Pro Asn Ser Ala Ile Ile Leu His Tyr Ala Trp His Gly Gln 
        515                 520                 525             


Gly Gln Ser Pro Ser Ile Arg Gln Leu Ile Met His Ala Met Ala Glu 
    530                 535                 540                 


Trp Tyr Met Arg Gly Glu Gln Tyr Asp Gln Ala Lys Leu Ser Arg Ile 
545                 550                 555                 560 


Leu Asp Val Ala Gln Asp Leu Lys Ala Leu Ser Met Leu Leu Asn Gly 
                565                 570                 575     


Xaa Pro Phe Ala Phe Val Ile Asp Leu Ala Ala Leu Ala Ser Arg Arg 
            580                 585                 590         


Glu Tyr Leu Lys Leu Asp Lys Trp Leu Xaa Asp Lys Ile Arg Glu His 
        595                 600                 605             


Gly Glu Pro Phe Ile Gln Ala Cys Met Xaa Phe Leu Lys Arg Arg Cys 
    610                 615                 620                 


Pro Ser Ile Leu Gly Gly Leu Ala Pro Glu Lys Asp Gln Pro Lys Ser 
625                 630                 635                 640 


Ala Gln Leu Pro Pro Glu Xaa Leu Ala Xaa Met Leu Ala Cys Leu Gln 
                645                 650                 655     


Ala Cys Ala Gly Ser Val Ser Gln Glu Leu Ser Glu Xaa Ile Leu Xaa 
            660                 665                 670         


Met Val Ala Asn Cys Ser Asn Val Met Asn Lys Ala Arg Gln Pro Pro 
        675                 680                 685             


Pro Gly Val Met Pro Lys Gly Arg Pro Pro Ser Ala Ser Ser Leu Asp 
    690                 695                 700                 


Ala Ile Ser Pro Val Gln Ile Asp Pro Leu Ala Gly Met Xaa Ser Leu 
705                 710                 715                 720 


Ser Ile Gly Gly Ser Ala Ala Pro His Xaa Gln Ser Met Gln Gly Phe 
                725                 730                 735     


Pro Pro Asn Leu Gly Ser Ala Phe Ser Xaa Pro Gln Ser Pro Ala Lys 
            740                 745                 750         


Ala Phe Pro Pro Leu Ser Xaa Pro Asn Gln Xaa Xaa Ala Phe Ser Gly 
        755                 760                 765             


Ile Gly Gly Leu Ser Ser Gln Leu Pro Val Gly Gly Leu Gly Xaa Gly 
    770                 775                 780                 


Ser Leu Xaa Gly Ile Gly Xaa Gly Ala Leu Gly Leu Pro Ala Val Asn 
785                 790                 795                 800 


Asn Asp Pro Phe Val Gln Arg Lys Leu Gly Xaa Ser Gly Leu Asn Gln 
                805                 810                 815     


Pro Xaa Phe Gln Gln Ser Lys Met Lys Pro Ser Asp Leu Ser Gln Val 
            820                 825                 830         


Trp Pro Glu Ala Asn Gln His Phe Ser Lys Glu Ile Asp Asp Glu Ala 
        835                 840                 845             


Asn Ser Tyr Phe Gln Arg Ile Tyr Asn His Pro Pro His Pro Xaa Met 
    850                 855                 860                 


Ser Val Asp Glu Val Leu Glu Met Leu Gln Arg Phe Lys Asp Ser Xaa 
865                 870                 875                 880 


Ile Lys Arg Glu Arg Glu Val Phe Asn Cys Met Leu Arg Asn Leu Phe 
                885                 890                 895     


Glu Glu Tyr Arg Phe Phe Pro Gln Tyr Pro Asp Lys Glu Leu His Ile 
            900                 905                 910         


Xaa Ala Cys Leu Phe Gly Gly Ile Ile Glu Lys Gly Leu Val Xaa Tyr 
        915                 920                 925             


Met Ala Leu Gly Leu Ala Leu Arg Tyr Val Leu Glu Ala Leu Arg Lys 
    930                 935                 940                 


Pro Phe Gly Ser Lys Met Tyr Tyr Phe Gly Ile Ala Ala Leu Asp Arg 
945                 950                 955                 960 


Phe Lys Asn Arg Leu Lys Asp Tyr Pro Gln Tyr Cys Gln His Leu Ala 
                965                 970                 975     


Ser Ile Ser His Phe Met Gln Phe Pro His His Leu Gln Glu Tyr Ile 
            980                 985                 990         


Glu Tyr Gly Gln Gln Ser Arg Asp  Pro Pro Val Lys Met  Gln Gly Ser 
        995                 1000                 1005             


Ile Xaa  Xaa Pro Gly Ser Ile  Ala Leu Ala Gln Ala  Gln Ala Gln 
    1010                 1015                 1020             


Ala Gln  Val Pro Ala Lys Ala  Pro Leu Ala Gly Gln  Val Ser Xaa 
    1025                 1030                 1035             


Met Val  Xaa Xaa Ser Xaa Xaa  Xaa Xaa Val Ala Lys  Xaa Val Xaa 
    1040                 1045                 1050             


Val Xaa  Arg Pro Xaa Gly Val  Ser Phe Lys Lys Asp  Val Pro Pro 
    1055                 1060                 1065             


Ser Ile  Asn Xaa Xaa Asn Ile  Asp Xaa Leu Leu Val  Ala Xaa Asp 
    1070                 1075                 1080             


Gln Xaa  Glu Arg Ile Val Glu  Pro Pro Glu Asn Ile  Gln Glu Lys 
    1085                 1090                 1095             


Ile Ala  Phe Ile Phe Asn Asn  Leu Ser Gln Ser Asn  Met Xaa Gln 
    1100                 1105                 1110             


Lys Val  Glu Glu Leu Lys Glu  Xaa Val Lys Glu Glu  Phe Met Pro 
    1115                 1120                 1125             


Trp Val  Ser Gln Tyr Leu Val  Met Lys Arg Val Ser  Ile Glu Pro 
    1130                 1135                 1140             


Asn Phe  His Ser Leu Tyr Ser  Asn Phe Leu Asp Xaa  Leu Lys Asn 
    1145                 1150                 1155             


Pro Glu  Phe Asn Lys Met Val  Leu Asn Glu Xaa Tyr  Arg Asn Ile 
    1160                 1165                 1170             


Lys Val  Leu Leu Xaa Ser Asp  Lys Ala Ala Ala Asn  Phe Ser Asp 
    1175                 1180                 1185             


Arg Ser  Leu Leu Lys Asn Leu  Gly His Trp Leu Gly  Met Ile Xaa 
    1190                 1195                 1200             


Leu Ala  Lys Asn Lys Pro Ile  Leu His Xaa Asp Leu  Asp Val Lys 
    1205                 1210                 1215             


Ser Leu  Leu Leu Glu Ala Tyr  Val Lys Gly Gln Gln  Glu Leu Leu 
    1220                 1225                 1230             


Tyr Val  Val Pro Phe Val Ala  Lys Val Leu Glu Ser  Ser Ile Arg 
    1235                 1240                 1245             


Ser Val  Val Phe Arg Pro Pro  Asn Pro Trp Xaa Met  Ala Ile Met 
    1250                 1255                 1260             


Asn Val  Leu Ala Glu Leu His  Gln Glu His Asp Leu  Lys Leu Asn 
    1265                 1270                 1275             


Leu Lys  Phe Glu Ile Glu Val  Leu Cys Lys Asn Leu  Ala Leu Asp 
    1280                 1285                 1290             


Ile Asn  Glu Leu Lys Pro Gly  Asn Leu Leu Lys Asp  Lys Asp Arg 
    1295                 1300                 1305             


Leu Lys  Asn Leu Asp Glu Gln  Leu Ser Ala Pro Lys  Lys Asp Val 
    1310                 1315                 1320             


Lys Gln  Pro Glu Glu Leu Pro  Pro Ile Xaa Xaa Xaa  Xaa Xaa Ser 
    1325                 1330                 1335             


Xaa Xaa  Pro Ala Xaa Asn Xaa  Xaa Cys Xaa Ala Xaa  Val Pro Pro 
    1340                 1345                 1350             


Gln Pro  Gln Tyr Ser Tyr His  Asp Ile Asn Val Tyr  Ser Leu Ala 
    1355                 1360                 1365             


Gly Leu  Ala Pro His Ile Xaa  Leu Asn Pro Xaa Ile  Pro Leu Phe 
    1370                 1375                 1380             


Gln Ala  His Pro Gln Leu Lys  Gln Cys Val Arg Gln  Ala Ile Glu 
    1385                 1390                 1395             


Arg Ala  Val Gln Glu Leu Val  His Pro Val Val Asp  Arg Ser Ile 
    1400                 1405                 1410             


Lys Ile  Ala Met Xaa Xaa Cys  Glu Gln Ile Val Arg  Lys Asp Phe 
    1415                 1420                 1425             


Ala Leu  Asp Ser Glu Glu Ser  Arg Met Arg Ile Ala  Ala His His 
    1430                 1435                 1440             


Met Met  Arg Asn Leu Xaa Ala  Gly Met Ala Met Ile  Xaa Cys Arg 
    1445                 1450                 1455             


Glu Pro  Leu Leu Met Ser Ile  Ser Xaa Asn Leu Lys  Asn Ser Phe 
    1460                 1465                 1470             


Ala Ser  Ala Leu Arg Xaa Ala  Ser Pro Gln Gln Arg  Glu Met Met 
    1475                 1480                 1485             


Asp Gln  Ala Ala Ala Gln Leu  Ala Gln Asp Asn Cys  Glu Leu Ala 
    1490                 1495                 1500             


Cys Cys  Phe Ile Gln Lys Xaa  Ala Val Glu Lys Ala  Gly Pro Glu 
    1505                 1510                 1515             


Met Asp  Lys Arg Leu Ala Xaa  Glu Phe Glu Leu Arg  Lys His Ala 
    1520                 1525                 1530             


Arg Gln  Glu Gly Arg Arg Tyr  Cys Asp Pro Val Val  Leu Xaa Tyr 
    1535                 1540                 1545             


Gln Ala  Glu Arg Met Pro Glu  Gln Ile Arg Leu Lys  Val Gly Gly 
    1550                 1555                 1560             


Val Asp  Pro Lys Gln Leu Ala  Val Tyr Glu Glu Phe  Ala Arg Asn 
    1565                 1570                 1575             


Val Pro  Gly Phe Leu Pro Xaa  Asn Asp Leu Ser Gln  Pro Xaa Gly 
    1580                 1585                 1590             


Phe Leu  Ala Gln Pro Met Lys  Gln Ala Trp Ala Xaa  Asp Asp Val 
    1595                 1600                 1605             


Ala Gln  Ile Tyr Asp Lys Cys  Ile Xaa Glu Leu Glu  Gln His Leu 
    1610                 1615                 1620             


His Ala  Ile Pro Pro Xaa Leu  Ala Met Asn Pro Gln  Ala Gln Ala 
    1625                 1630                 1635             


Leu Arg  Ser Leu Leu Glu Val  Val Val Leu Ser Arg  Asn Ser Arg 
    1640                 1645                 1650             


Asp Ala  Ile Ala Ala Leu Gly  Leu Leu Gln Lys Ala  Val Glu Gly 
    1655                 1660                 1665             


Leu Leu  Asp Ala Xaa Ser Gly  Ala Asp Ala Asp Leu  Leu Leu Arg 
    1670                 1675                 1680             


Tyr Arg  Glu Cys His Leu Leu  Val Leu Lys Ala Leu  Gln Asp Gly 
    1685                 1690                 1695             


Arg Ala  Tyr Gly Ser Pro Trp  Cys Asn Lys Gln Ile  Xaa Arg Cys 
    1700                 1705                 1710             


Leu Ile  Glu Cys Arg Asp Glu  Tyr Lys Tyr Asn Val  Glu Ala Val 
    1715                 1720                 1725             


Glu Leu  Leu Ile Arg Asn His  Leu Val Asn Met Gln  Gln Tyr Asp 
    1730                 1735                 1740             


Leu His  Leu Ala Gln Ser Met  Glu Asn Gly Leu Asn  Tyr Met Ala 
    1745                 1750                 1755             


Val Ala  Phe Ala Met Gln Leu  Val Lys Ile Leu Leu  Val Asp Glu 
    1760                 1765                 1770             


Arg Ser  Val Ala His Val Xaa  Glu Ala Asp Leu Phe  His Xaa Ile 
    1775                 1780                 1785             


Glu Xaa  Leu Met Arg Ile Asn  Ala His Ser Arg Gly  Asn Ala Pro 
    1790                 1795                 1800             


Glu Gly  Leu Pro Gln Leu Met  Glu Val Val Arg Ser  Asn Tyr Glu 
    1805                 1810                 1815             


Ala Met  Ile Asp Arg Ala His  Gly Gly Pro Asn Phe  Met Met His 
    1820                 1825                 1830             


Ser Gly  Ile Ser Gln Ala Ser  Glu Tyr Asp Asp Pro  Pro Gly Leu 
    1835                 1840                 1845             


Arg Glu  Lys Ala Glu Tyr Leu  Leu Arg Glu Trp Val  Asn Leu Tyr 
    1850                 1855                 1860             


His Ser  Ala Ala Ala Gly Arg  Asp Ser Xaa Lys Ala  Phe Ser Ala 
    1865                 1870                 1875             


Phe Val  Gly Gln Met His Gln  Gln Gly Ile Leu Lys  Xaa Asp Asp 
    1880                 1885                 1890             


Leu Ile  Xaa Arg Phe Phe Arg  Leu Cys Xaa Glu Met  Cys Val Glu 
    1895                 1900                 1905             


Ile Ser  Tyr Arg Ala Gln Ala  Glu Gln Gln His Asn  Pro Ala Ala 
    1910                 1915                 1920             


Asn Pro  Xaa Met Ile Arg Ala  Lys Cys Tyr His Asn  Leu Asp Ala 
    1925                 1930                 1935             


Phe Val  Arg Leu Ile Ala Leu  Leu Val Lys His Ser  Gly Glu Ala 
    1940                 1945                 1950             


Xaa Asn  Xaa Val Xaa Lys Ile  Asn Leu Leu Asn Lys  Val Leu Gly 
    1955                 1960                 1965             


Ile Val  Val Gly Val Leu Leu  Gln Asp His Asp Val  Arg Gln Ser 
    1970                 1975                 1980             


Glu Phe  Gln Gln Leu Pro Tyr  His Arg Ile Phe Ile  Met Leu Leu 
    1985                 1990                 1995             


Leu Glu  Leu Asn Ala Pro Glu  His Val Leu Glu Xaa  Ile Asn Phe 
    2000                 2005                 2010             


Gln Xaa  Leu Xaa Ala Phe Cys  Asn Xaa Phe His Ile  Leu Arg Pro 
    2015                 2020                 2025             


Xaa Lys  Ala Pro Gly Phe Val  Tyr Ala Trp Leu Glu  Leu Ile Ser 
    2030                 2035                 2040             


His Arg  Ile Phe Ile Ala Arg  Met Leu Ala His Xaa  Pro Gln Gln 
    2045                 2050                 2055             


Lys Gly  Trp Pro Met Tyr Ala  Gln Leu Leu Ile Asp  Leu Phe Lys 
    2060                 2065                 2070             


Tyr Leu  Ala Pro Phe Leu Arg  Asn Val Glu Leu Xaa  Lys Pro Met 
    2075                 2080                 2085             


Gln Ile  Leu Tyr Lys Gly Xaa  Leu Arg Val Leu Leu  Val Leu Leu 
    2090                 2095                 2100             


His Asp  Phe Pro Glu Phe Leu  Cys Asp Tyr His Tyr  Gly Phe Cys 
    2105                 2110                 2115             


Asp Val  Ile Pro Pro Asn Cys  Ile Gln Leu Arg Asn  Leu Ile Leu 
    2120                 2125                 2130             


Ser Ala  Phe Pro Arg Asn Met  Arg Leu Pro Asp Pro  Phe Xaa Pro 
    2135                 2140                 2145             


Asn Leu  Lys Val Asp Met Leu  Ser Glu Ile Asn Ile  Ala Pro Arg 
    2150                 2155                 2160             


Ile Leu  Xaa Asn Phe Xaa Gly  Val Met Pro Pro Gln  Phe Lys Lys 
    2165                 2170                 2175             


Asp Leu  Asp Ser Tyr Leu Lys  Xaa Arg Ser Pro Val  Xaa Phe Leu 
    2180                 2185                 2190             


Ser Asp  Leu Arg Ser Asn Leu  Gln Val Ser Asn Glu  Pro Gly Asn 
    2195                 2200                 2205             


Arg Tyr  Asn Leu Gln Leu Ile  Asn Ala Leu Val Leu  Tyr Val Gly 
    2210                 2215                 2220             


Xaa Gln  Ala Ile Ala His Ile  His Asn Lys Gly Ser  Xaa Pro Ser 
    2225                 2230                 2235             


Met Ser  Xaa Ile Xaa His Ser  Ala His Met Asp Ile  Phe Gln Asn 
    2240                 2245                 2250             


Leu Ala  Val Asp Leu Asp Xaa  Glu Gly Arg Tyr Leu  Phe Leu Asn 
    2255                 2260                 2265             


Ala Ile  Ala Asn Gln Leu Arg  Tyr Pro Asn Ser His  Xaa His Tyr 
    2270                 2275                 2280             


Phe Ser  Cys Xaa Met Leu Tyr  Leu Phe Ala Glu Ala  Asn Xaa Glu 
    2285                 2290                 2295             


Ala Ile  Gln Glu Gln Ile Xaa  Arg Val Leu Leu Glu  Arg Leu Ile 
    2300                 2305                 2310             


Val Asn  Arg Pro His Pro Trp  Gly Leu Leu Ile Xaa  Phe Ile Glu 
    2315                 2320                 2325             


Leu Ile  Lys Asn Pro Ala Phe  Lys Phe Trp Asn His  Glu Phe Val 
    2330                 2335                 2340             


His Cys  Ala Pro Glu Ile Glu  Lys Leu Phe Gln Ser  Val Ala Gln 
    2345                 2350                 2355             


Cys Cys  Met Gly Gln Lys Gln  Ala Gln Gln Val Met  Glu Gly Xaa 
    2360                 2365                 2370             


Gly Ala  Ser 
    2375     


<210> 6511
<211> 439
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<400> 6511
Pro Xaa Leu Ala Met Asn Pro Gln Ala Gln Ala Leu Arg Ser Leu Leu 
1               5                   10                  15      


Glu Val Val Val Leu Ser Arg Asn Ser Arg Asp Ala Ile Ala Ala Leu 
            20                  25                  30          


Gly Leu Leu Gln Lys Ala Val Glu Gly Leu Leu Asp Ala Xaa Ser Gly 
        35                  40                  45              


Ala Asp Ala Asp Leu Leu Leu Arg Tyr Arg Glu Cys His Leu Leu Val 
    50                  55                  60                  


Leu Lys Ala Leu Gln Asp Gly Arg Ala Tyr Gly Ser Pro Trp Cys Asn 
65                  70                  75                  80  


Lys Gln Ile Xaa Arg Cys Leu Ile Glu Cys Arg Asp Glu Tyr Lys Tyr 
                85                  90                  95      


Asn Val Glu Ala Val Glu Leu Leu Ile Arg Asn His Leu Val Asn Met 
            100                 105                 110         


Gln Gln Tyr Asp Leu His Leu Ala Gln Ser Met Glu Asn Gly Leu Asn 
        115                 120                 125             


Tyr Met Ala Val Ala Phe Ala Met Gln Leu Val Lys Ile Leu Leu Val 
    130                 135                 140                 


Asp Glu Arg Ser Val Ala His Val Xaa Glu Ala Asp Leu Phe His Xaa 
145                 150                 155                 160 


Ile Glu Xaa Leu Met Arg Ile Asn Ala His Ser Arg Gly Asn Ala Pro 
                165                 170                 175     


Glu Gly Leu Pro Gln Leu Met Glu Val Val Arg Ser Asn Tyr Glu Ala 
            180                 185                 190         


Met Ile Asp Arg Ala His Gly Gly Pro Asn Phe Met Met His Ser Gly 
        195                 200                 205             


Ile Ser Gln Ala Ser Glu Tyr Asp Asp Pro Pro Gly Leu Arg Glu Lys 
    210                 215                 220                 


Ala Glu Tyr Leu Leu Arg Glu Trp Val Asn Leu Tyr His Ser Ala Ala 
225                 230                 235                 240 


Ala Gly Arg Asp Ser Xaa Lys Ala Phe Ser Ala Phe Val Gly Gln Val 
                245                 250                 255     


Glu Leu Leu Glu Arg Lys Met His Gln Gln Gly Ile Leu Lys Xaa Asp 
            260                 265                 270         


Asp Leu Ile Xaa Arg Phe Phe Arg Leu Cys Xaa Glu Met Cys Val Glu 
        275                 280                 285             


Ile Ser Tyr Arg Ala Gln Ala Glu Gln Gln His Asn Pro Ala Ala Asn 
    290                 295                 300                 


Pro Xaa Met Ile Arg Ala Lys Cys Tyr His Asn Leu Asp Ala Phe Val 
305                 310                 315                 320 


Arg Leu Ile Ala Leu Leu Val Lys His Ser Gly Glu Ala Xaa Asn Xaa 
                325                 330                 335     


Val Xaa Lys Ile Asn Leu Leu Asn Lys Val Leu Gly Ile Val Val Gly 
            340                 345                 350         


Val Leu Leu Gln Asp His Asp Val Arg Gln Ser Glu Phe Gln Gln Leu 
        355                 360                 365             


Pro Tyr His Arg Ile Phe Ile Met Leu Leu Leu Glu Leu Asn Ala Pro 
    370                 375                 380                 


Glu His Val Leu Glu Xaa Ile Asn Phe Gln Xaa Leu Xaa Ala Phe Cys 
385                 390                 395                 400 


Asn Xaa Phe His Ile Leu Arg Pro Xaa Lys Ala Pro Gly Phe Val Tyr 
                405                 410                 415     


Ala Trp Leu Glu Leu Ile Ser His Arg Ile Phe Ile Ala Arg Met Leu 
            420                 425                 430         


Ala His Xaa Pro Gln Gln Lys 
        435                 


<210> 6512
<211> 277
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<400> 6512
Arg Arg Glu Tyr Leu Lys Leu Asp Lys Trp Leu Xaa Asp Lys Ile Arg 
1               5                   10                  15      


Glu His Gly Glu Pro Phe Ile Gln Ala Cys Met Xaa Phe Leu Lys Arg 
            20                  25                  30          


Arg Cys Pro Ser Ile Leu Gly Gly Leu Ala Pro Glu Lys Asp Gln Pro 
        35                  40                  45              


Lys Ser Ala Gln Leu Pro Pro Glu Xaa Leu Ala Xaa Met Leu Ala Cys 
    50                  55                  60                  


Leu Gln Ala Cys Ala Gly Ser Val Ser Gln Glu Leu Ser Glu Xaa Ile 
65                  70                  75                  80  


Leu Xaa Met Val Ala Asn Cys Ser Asn Val Met Asn Lys Ala Arg Gln 
                85                  90                  95      


Pro Pro Pro Gly Val Met Pro Lys Gly Arg Pro Pro Ser Ala Ser Ser 
            100                 105                 110         


Leu Asp Ala Ile Ser Pro Val Gln Ile Asp Pro Leu Ala Gly Met Xaa 
        115                 120                 125             


Ser Leu Ser Ile Gly Gly Ser Ala Ala Pro His Xaa Gln Ser Met Gln 
    130                 135                 140                 


Gly Phe Pro Pro Asn Leu Gly Ser Ala Phe Ser Xaa Pro Gln Ser Pro 
145                 150                 155                 160 


Ala Lys Ala Phe Pro Pro Leu Ser Xaa Pro Asn Gln Xaa Xaa Ala Phe 
                165                 170                 175     


Ser Gly Ile Gly Gly Leu Ser Ser Gln Leu Pro Gly Gly Leu Gly Xaa 
            180                 185                 190         


Gly Ser Leu Xaa Gly Ile Gly Xaa Gly Ala Leu Gly Leu Pro Ala Val 
        195                 200                 205             


Asn Asn Asp Pro Phe Val Gln Arg Lys Leu Gly Xaa Ser Gly Leu Asn 
    210                 215                 220                 


Gln Pro Xaa Phe Gln Gln Ser Lys Met Lys Pro Ser Asp Leu Ser Gln 
225                 230                 235                 240 


Val Trp Pro Glu Ala Asn Gln His Phe Ser Lys Glu Ile Asp Asp Glu 
                245                 250                 255     


Ala Asn Ser Tyr Phe Gln Arg Ile Tyr Asn His Pro Pro His Pro Xaa 
            260                 265                 270         


Met Ser Val Asp Glu 
        275         


<210> 6513
<211> 185
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (40)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<400> 6513
Xaa Ala Glu Leu His Gln Glu His Asp Leu Lys Asp Lys Asp Arg Leu 
1               5                   10                  15      


Lys Asn Leu Asp Glu Gln Leu Ser Ala Pro Lys Lys Asp Val Lys Gln 
            20                  25                  30          


Pro Glu Glu Leu Pro Pro Ile Xaa Xaa Xaa Xaa Xaa Ser Xaa Xaa Pro 
        35                  40                  45              


Ala Xaa Asn Xaa Xaa Cys Xaa Ala Xaa Val Pro Pro Gln Pro Gln Tyr 
    50                  55                  60                  


Ser Tyr His Asp Ile Asn Val Tyr Ser Leu Ala Gly Leu Ala Pro His 
65                  70                  75                  80  


Ile Xaa Leu Asn Pro Xaa Ile Pro Leu Phe Gln Ala His Pro Gln Leu 
                85                  90                  95      


Lys Gln Cys Val Arg Gln Ala Ile Glu Arg Ala Val Gln Glu Leu Val 
            100                 105                 110         


His Pro Val Val Asp Arg Ser Ile Lys Ile Ala Met Xaa Xaa Cys Glu 
        115                 120                 125             


Gln Ile Val Arg Lys Asp Phe Ala Leu Asp Ser Glu Glu Ser Arg Met 
    130                 135                 140                 


Arg Ile Ala Ala His His Met Met Arg Asn Leu Xaa Ala Gly Met Ala 
145                 150                 155                 160 


Met Ile Xaa Cys Arg Glu Pro Leu Leu Met Ser Ile Ser Xaa Asn Leu 
                165                 170                 175     


Lys Asn Ser Phe Ala Ser Ala Leu Arg 
            180                 185 


<210> 6514
<211> 241
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<400> 6514
Xaa Ile Xaa Xaa Pro Gly Ser Ile Ala Leu Ala Gln Ala Gln Ala Gln 
1               5                   10                  15      


Ala Gln Val Pro Ala Lys Ala Pro Leu Ala Gly Gln Val Ser Xaa Met 
            20                  25                  30          


Val Xaa Xaa Ser Xaa Xaa Xaa Xaa Val Ala Lys Xaa Val Xaa Val Xaa 
        35                  40                  45              


Arg Pro Xaa Gly Val Ser Phe Lys Lys Asp Val Pro Pro Ser Ile Asn 
    50                  55                  60                  


Xaa Xaa Asn Ile Asp Xaa Leu Leu Val Ala Xaa Asp Gln Xaa Glu Arg 
65                  70                  75                  80  


Ile Val Glu Pro Pro Glu Asn Ile Gln Glu Lys Ile Ala Phe Ile Phe 
                85                  90                  95      


Asn Asn Leu Ser Gln Ser Asn Met Xaa Gln Lys Val Glu Glu Leu Lys 
            100                 105                 110         


Glu Xaa Val Lys Glu Glu Phe Met Pro Trp Val Ser Gln Tyr Leu Val 
        115                 120                 125             


Met Lys Arg Val Ser Ile Glu Pro Asn Phe His Ser Leu Tyr Ser Asn 
    130                 135                 140                 


Phe Leu Asp Xaa Leu Lys Asn Pro Glu Phe Asn Lys Met Val Leu Asn 
145                 150                 155                 160 


Glu Xaa Tyr Arg Asn Ile Lys Asp Leu Asp Val Lys Ser Leu Leu Leu 
                165                 170                 175     


Glu Ala Tyr Val Lys Gly Gln Gln Glu Leu Leu Tyr Val Val Pro Phe 
            180                 185                 190         


Val Ala Lys Val Leu Glu Ser Ser Ile Arg Ser Val Val Phe Arg Pro 
        195                 200                 205             


Pro Asn Pro Trp Xaa Met Ala Ile Met Asn Val Leu Ala Glu Leu His 
    210                 215                 220                 


Gln Glu His Asp Leu Lys Leu Asn Leu Lys Phe Glu Ile Glu Val Leu 
225                 230                 235                 240 


Cys 
    


<210> 6515
<211> 68
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<400> 6515
Xaa Lys Ile Ala Met Xaa Xaa Cys Glu Gln Ile Val Arg Lys Asp Phe 
1               5                   10                  15      


Ala Leu Asp Ser Glu Glu Ser Arg Met Arg Ile Ala Ala His His Met 
            20                  25                  30          


Met Arg Asn Leu Xaa Ala Gly Met Ala Met Ile Xaa Cys Arg Glu Pro 
        35                  40                  45              


Leu Leu Met Ser Ile Ser Xaa Asn Leu Lys Asn Ser Phe Ala Ser Ala 
    50                  55                  60                  


Leu Arg Glu Gly 
65              


<210> 6516
<211> 193
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<400> 6516
Xaa Ser Ser Gln Leu Pro Val Gly Gly Leu Gly Xaa Gly Ser Leu Xaa 
1               5                   10                  15      


Gly Ile Gly Xaa Gly Ala Leu Gly Leu Pro Ala Val Asn Asn Asp Pro 
            20                  25                  30          


Phe Val Gln Arg Lys Leu Gly Xaa Ser Gly Leu Asn Gln Pro Xaa Phe 
        35                  40                  45              


Gln Gln Ser Lys Met Lys Pro Ser Asp Leu Ser Gln Val Trp Pro Glu 
    50                  55                  60                  


Ala Asn Gln His Phe Ser Lys Glu Ile Asp Asp Glu Ala Asn Ser Tyr 
65                  70                  75                  80  


Phe Gln Arg Ile Tyr Asn His Pro Pro His Pro Xaa Met Ser Val Asp 
                85                  90                  95      


Glu Tyr Pro Asp Lys Glu Leu His Ile Xaa Ala Cys Leu Phe Gly Gly 
            100                 105                 110         


Ile Ile Glu Lys Gly Leu Val Xaa Tyr Met Ala Leu Gly Leu Ala Leu 
        115                 120                 125             


Arg Tyr Val Leu Glu Ala Leu Arg Lys Pro Phe Gly Ser Lys Met Tyr 
    130                 135                 140                 


Tyr Phe Gly Ile Ala Ala Leu Asp Arg Phe Lys Asn Arg Leu Lys Asp 
145                 150                 155                 160 


Tyr Pro Gln Tyr Cys Gln His Leu Ala Ser Ile Ser His Phe Met Gln 
                165                 170                 175     


Phe Pro His His Leu Gln Glu Tyr Ile Glu Tyr Gly Gln Gln Ser Arg 
            180                 185                 190         


Asp 
    


<210> 6517
<211> 43
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<400> 6517
Gly Leu Asp Asp Val Glu Asn Ser Met Leu Tyr Tyr Asn Gln Ala Val 
1               5                   10                  15      


Ile Leu Tyr His Leu Arg Gln Tyr Xaa Glu Ala Ile Ser Val Gly Glu 
            20                  25                  30          


Lys Leu Tyr Gln Phe Ile Glu Pro Phe Asp Trp 
        35                  40              


<210> 6518
<211> 717
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(713)
<223> Selenocysteine

<400> 6518
Met Ala Ala Asp Lys Pro Ala Asp Gln Gly Ala Glu Lys His Glu Gly 
1               5                   10                  15      


Xaa Gly Gln Ser Ser Gly Ile Xaa Asp Gln Glu Lys Glu Leu Ser Xaa 
            20                  25                  30          


Asn Ala Phe Gln Ala Phe Xaa Ser Gly Asn Tyr Asp Ala Cys Leu Gln 
        35                  40                  45              


His Leu Ala Cys Leu Gln Asp Ile Asn Lys Asp Asp Tyr Lys Ile Ile 
    50                  55                  60                  


Leu Asn Xaa Ala Val Ala Glu Phe Phe Lys Ser Asn Gln Xaa Xaa Xaa 
65                  70                  75                  80  


Asp Asn Leu Arg Gln Xaa Leu Asn Gln Leu Lys Asn Gln Val His Ser 
                85                  90                  95      


Ala Val Glu Glu Met Asp Gly Leu Asp Asp Val Glu Asn Ser Met Leu 
            100                 105                 110         


Tyr Tyr Asn Gln Ala Val Ile Leu Tyr His Leu Arg Gln Tyr Xaa Glu 
        115                 120                 125             


Ala Ile Ser Val Gly Glu Lys Leu Tyr Gln Phe Ile Glu Pro Phe Glu 
    130                 135                 140                 


Glu Lys Phe Ala Gln Ala Val Cys Phe Leu Leu Val Asp Leu Tyr Ile 
145                 150                 155                 160 


Leu Xaa Tyr Gln Ala Glu Lys Ala Leu His Leu Leu Ala Val Leu Glu 
                165                 170                 175     


Lys Met Ile Ser Gln Gly Asn Asn Asn Lys Asn Gly Lys Asn Glu Xaa 
            180                 185                 190         


Gly Asn Asn Asn Asn Lys Asp Gly Ser Asn His Lys Ala Glu Ser Gly 
        195                 200                 205             


Ala Leu Ile Glu Ala Ala Lys Ser Lys Ile His Gln Tyr Lys Val Arg 
    210                 215                 220                 


Ala Tyr Ile Gln Met Lys Ser Leu Lys Ala Cys Lys Arg Glu Ile Lys 
225                 230                 235                 240 


Ser Val Met Asn Xaa Ala Gly Asn Ser Ala Pro Ser Leu Phe Leu Lys 
                245                 250                 255     


Ser Asn Phe Glu Tyr Leu Arg Gly Asn Tyr Arg Lys Ala Val Lys Leu 
            260                 265                 270         


Leu Asn Ser Ser Asn Ile Ala Glu His Pro Gly Phe Met Lys Xaa Gly 
        275                 280                 285             


Glu Cys Leu Arg Cys Met Phe Trp Asn Asn Leu Gly Cys Ile His Phe 
    290                 295                 300                 


Ala Met Ser Lys His Asn Leu Gly Ile Phe Tyr Phe Lys Lys Ala Leu 
305                 310                 315                 320 


Gln Glu Asn Asp Asn Val Cys Ala Gln Leu Ser Ala Gly Ser Xaa Asp 
                325                 330                 335     


Pro Gly Lys Lys Phe Ser Gly Arg Pro Met Cys Xaa Leu Leu Xaa Asn 
            340                 345                 350         


Lys Arg Tyr Glu Leu Leu Tyr Asn Cys Gly Ile Gln Leu Leu His Ile 
        355                 360                 365             


Gly Arg Pro Leu Ala Ala Phe Glu Cys Leu Ile Glu Ala Val Gln Val 
    370                 375                 380                 


Tyr His Ala Asn Pro Arg Leu Trp Leu Arg Leu Ala Glu Cys Cys Ile 
385                 390                 395                 400 


Ala Ala Asn Lys Gly Xaa Ser Glu Gln Glu Xaa Lys Gly Leu Pro Ser 
                405                 410                 415     


Lys Lys Gly Ile Val Gln Ser Ile Val Gly Gln Gly Tyr His Arg Lys 
            420                 425                 430         


Ile Val Leu Ala Ser Gln Ser Ile Gln Asn Xaa Val Tyr Asn Asp Gly 
        435                 440                 445             


Gln Ser Ser Ala Ile Pro Val Ala Ser Met Glu Phe Ala Ala Ile Cys 
    450                 455                 460                 


Leu Arg Asn Ala Leu Leu Leu Leu Pro Glu Glu Gln Gln Asp Pro Lys 
465                 470                 475                 480 


Gln Glu Asn Gly Ala Lys Asn Ser Asn Gln Leu Gly Gly Asn Xaa Glu 
                485                 490                 495     


Ser Ser Glu Ser Ser Glu Xaa Cys Arg Cys Ser Ile Leu Ala Cys Ser 
            500                 505                 510         


Ala Tyr Val Ala Leu Ala Leu Gly Asp Asn Leu Met Ala Leu Asn His 
        515                 520                 525             


Ala Asp Lys Leu Leu Gln Gln Pro Lys Leu Ser Gly Ser Leu Lys Phe 
    530                 535                 540                 


Leu Gly His Leu Tyr Ala Ala Glu Ala Leu Ile Ser Leu Asp Arg Ile 
545                 550                 555                 560 


Ser Asp Ala Ile Xaa His Leu Asn Pro Glu Asn Val Xaa Asp Val Ser 
                565                 570                 575     


Leu Gly Ile Ser Ser Asn Glu Gln Asp Gln Gly Ser Asp Lys Gly Glu 
            580                 585                 590         


Asn Glu Ala Met Glu Ser Ser Gly Lys Arg Ala Pro Gln Cys Tyr Pro 
        595                 600                 605             


Ser Ser Val Asn Ser Ala Arg Xaa Val Met Leu Phe Asn Leu Gly Ser 
    610                 615                 620                 


Ala Tyr Cys Leu Arg Ser Glu Tyr Asp Lys Ala Arg Lys Cys Leu His 
625                 630                 635                 640 


Gln Ala Ala Ser Met Ile His Pro Lys Glu Val Pro Pro Glu Ala Ile 
                645                 650                 655     


Leu Leu Ala Val Tyr Leu Glu Leu Gln Asn Gly Asn Xaa Gln Leu Ala 
            660                 665                 670         


Leu Gln Ile Ile Lys Arg Asn Gln Leu Leu Pro Ala Val Lys Xaa His 
        675                 680                 685             


Ser Glu Val Arg Lys Lys Pro Val Phe Gln Pro Val His Pro Ile Gln 
    690                 695                 700                 


Pro Ile Gln Met Pro Ala Phe Xaa Xaa Val Gln Arg Lys 
705                 710                 715         


<210> 6519
<211> 744
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(740)
<223> Selenocysteine

<400> 6519
Met Ala Ala Asp Lys Pro Ala Asp Gln Gly Ala Glu Lys His Glu Gly 
1               5                   10                  15      


Xaa Gly Gln Ser Ser Gly Ile Xaa Asp Gln Glu Lys Glu Leu Ser Xaa 
            20                  25                  30          


Asn Ala Phe Gln Ala Phe Xaa Ser Gly Asn Tyr Asp Ala Cys Leu Gln 
        35                  40                  45              


His Leu Ala Cys Leu Gln Asp Ile Asn Lys Asp Asp Tyr Lys Ile Ile 
    50                  55                  60                  


Leu Asn Xaa Ala Val Ala Glu Phe Phe Lys Ser Asn Gln Xaa Xaa Xaa 
65                  70                  75                  80  


Asp Asn Leu Arg Gln Xaa Leu Asn Gln Leu Lys Asn Gln Val His Ser 
                85                  90                  95      


Ala Val Glu Glu Met Asp Gly Leu Asp Asp Val Glu Asn Ser Met Leu 
            100                 105                 110         


Tyr Tyr Asn Gln Ala Val Ile Leu Tyr His Leu Arg Gln Tyr Xaa Glu 
        115                 120                 125             


Ala Ile Ser Val Gly Glu Lys Leu Tyr Gln Phe Ile Glu Pro Phe Glu 
    130                 135                 140                 


Glu Lys Phe Ala Gln Ala Val Cys Phe Leu Leu Val Asp Leu Tyr Ile 
145                 150                 155                 160 


Leu Xaa Tyr Gln Ala Glu Lys Ala Leu His Leu Leu Ala Val Leu Glu 
                165                 170                 175     


Lys Met Ile Ser Gln Gly Asn Asn Asn Lys Asn Gly Lys Asn Glu Xaa 
            180                 185                 190         


Gly Asn Asn Asn Asn Lys Asp Gly Ser Asn His Lys Ala Glu Ser Gly 
        195                 200                 205             


Ala Leu Ile Glu Ala Ala Lys Ser Lys Ile His Gln Tyr Lys Val Arg 
    210                 215                 220                 


Ala Tyr Ile Gln Met Lys Ser Leu Lys Ala Cys Lys Arg Glu Ile Lys 
225                 230                 235                 240 


Ser Val Met Asn Xaa Ala Gly Asn Ser Ala Pro Ser Leu Phe Leu Lys 
                245                 250                 255     


Ser Asn Phe Glu Tyr Leu Arg Gly Asn Tyr Arg Lys Ala Val Lys Leu 
            260                 265                 270         


Leu Asn Ser Ser Asn Ile Ala Glu His Pro Gly Phe Met Lys Xaa Gly 
        275                 280                 285             


Glu Cys Leu Arg Cys Met Phe Trp Asn Asn Leu Gly Cys Ile His Phe 
    290                 295                 300                 


Ala Met Ser Lys His Asn Leu Gly Ile Phe Tyr Phe Lys Lys Ala Leu 
305                 310                 315                 320 


Gln Glu Asn Asp Asn Val Cys Ala Gln Leu Ser Ala Gly Ser Xaa Asp 
                325                 330                 335     


Pro Gly Lys Lys Phe Ser Gly Arg Pro Met Cys Xaa Leu Leu Xaa Asn 
            340                 345                 350         


Lys Arg Tyr Glu Leu Leu Tyr Asn Cys Gly Ile Gln Leu Leu His Ile 
        355                 360                 365             


Gly Arg Pro Leu Ala Ala Phe Glu Cys Leu Ile Glu Ala Val Gln Val 
    370                 375                 380                 


Tyr His Ala Asn Pro Arg Leu Trp Leu Arg Leu Ala Glu Cys Cys Ile 
385                 390                 395                 400 


Ala Ala Asn Lys Gly Xaa Ser Glu Gln Glu Xaa Lys Gly Leu Pro Ser 
                405                 410                 415     


Lys Lys Gly Ile Val Gln Ser Ile Val Gly Gln Gly Tyr His Arg Lys 
            420                 425                 430         


Ile Val Leu Ala Ser Gln Ser Ile Gln Asn Xaa Val Tyr Asn Asp Gly 
        435                 440                 445             


Gln Ser Ser Ala Ile Pro Val Ala Ser Met Glu Phe Ala Ala Ile Cys 
    450                 455                 460                 


Leu Arg Asn Ala Leu Leu Leu Leu Pro Glu Glu Gln Gln Asp Pro Lys 
465                 470                 475                 480 


Gln Glu Asn Gly Ala Lys Asn Ser Asn Gln Leu Gly Gly Asn Xaa Glu 
                485                 490                 495     


Ser Ser Glu Ser Ser Glu Xaa Cys Ser Ser Lys Ser His Asp Gly Asp 
            500                 505                 510         


Lys Phe Ile Pro Ala Pro Pro Ser Ser Pro Leu Arg Lys Gln Glu Leu 
        515                 520                 525             


Glu Asn Leu Lys Cys Ser Ile Leu Ala Cys Ser Ala Tyr Val Ala Leu 
    530                 535                 540                 


Ala Leu Gly Asp Asn Leu Met Ala Leu Asn His Ala Asp Lys Leu Leu 
545                 550                 555                 560 


Gln Gln Pro Lys Leu Ser Gly Ser Leu Lys Phe Leu Gly His Leu Tyr 
                565                 570                 575     


Ala Ala Glu Ala Leu Ile Ser Leu Asp Arg Ile Ser Asp Ala Ile Xaa 
            580                 585                 590         


His Leu Asn Pro Glu Asn Val Xaa Asp Val Ser Leu Gly Ile Ser Ser 
        595                 600                 605             


Asn Glu Gln Asp Gln Gly Ser Asp Lys Gly Glu Asn Glu Ala Met Glu 
    610                 615                 620                 


Ser Ser Gly Lys Arg Ala Pro Gln Cys Tyr Pro Ser Ser Val Asn Ser 
625                 630                 635                 640 


Ala Arg Xaa Val Met Leu Phe Asn Leu Gly Ser Ala Tyr Cys Leu Arg 
                645                 650                 655     


Ser Glu Tyr Asp Lys Ala Arg Lys Cys Leu His Gln Ala Ala Ser Met 
            660                 665                 670         


Ile His Pro Lys Glu Val Pro Pro Glu Ala Ile Leu Leu Ala Val Tyr 
        675                 680                 685             


Leu Glu Leu Gln Asn Gly Asn Xaa Gln Leu Ala Leu Gln Ile Ile Lys 
    690                 695                 700                 


Arg Asn Gln Leu Leu Pro Ala Val Lys Xaa His Ser Glu Val Arg Lys 
705                 710                 715                 720 


Lys Pro Val Phe Gln Pro Val His Pro Ile Gln Pro Ile Gln Met Pro 
                725                 730                 735     


Ala Phe Xaa Xaa Val Gln Arg Lys 
            740                 


<210> 6520
<211> 609
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<400> 6520
Met Ala Ala Asp Lys Pro Ala Asp Gln Gly Ala Glu Lys His Glu Gly 
1               5                   10                  15      


Xaa Gly Gln Ser Ser Gly Ile Xaa Asp Gln Glu Lys Glu Leu Ser Xaa 
            20                  25                  30          


Asn Ala Phe Gln Ala Phe Xaa Val His Ser Ala Val Glu Glu Met Asp 
        35                  40                  45              


Gly Leu Asp Asp Val Glu Asn Ser Met Leu Tyr Tyr Asn Gln Ala Val 
    50                  55                  60                  


Ile Leu Tyr His Leu Arg Gln Tyr Xaa Glu Ala Ile Ser Val Gly Glu 
65                  70                  75                  80  


Lys Leu Tyr Gln Phe Ile Glu Pro Phe Glu Glu Lys Phe Ala Gln Ala 
                85                  90                  95      


Val Cys Phe Leu Leu Val Asp Leu Tyr Ile Leu Xaa Tyr Gln Ala Glu 
            100                 105                 110         


Lys Ala Leu His Leu Leu Ala Val Leu Glu Lys Met Ile Ser Gln Gly 
        115                 120                 125             


Asn Asn Asn Lys Asn Gly Lys Asn Glu Xaa Gly Asn Asn Asn Asn Lys 
    130                 135                 140                 


Asp Gly Ser Asn His Lys Ala Glu Ser Gly Ala Leu Ile Glu Ala Ala 
145                 150                 155                 160 


Lys Ser Lys Ile His Gln Tyr Lys Val Arg Ala Tyr Ile Gln Met Lys 
                165                 170                 175     


Ser Leu Lys Ala Cys Lys Arg Glu Ile Lys Ser Val Met Asn Xaa Ala 
            180                 185                 190         


Gly Asn Ser Ala Pro Ser Leu Phe Leu Lys Ser Asn Phe Glu Tyr Leu 
        195                 200                 205             


Arg Gly Asn Tyr Arg Lys Ala Val Lys Leu Leu Asn Ser Ser Asn Ile 
    210                 215                 220                 


Ala Glu His Pro Gly Phe Met Lys Xaa Gly Glu Cys Leu Arg Cys Met 
225                 230                 235                 240 


Phe Trp Asn Asn Leu Gly Cys Ile His Phe Ala Met Ser Lys His Asn 
                245                 250                 255     


Leu Gly Ile Phe Tyr Phe Lys Lys Ala Leu Gln Glu Asn Asp Asn Val 
            260                 265                 270         


Cys Ala Gln Leu Ser Ala Gly Ser Xaa Asp Pro Gly Lys Lys Phe Ser 
        275                 280                 285             


Gly Arg Pro Met Cys Xaa Leu Leu Xaa Asn Lys Arg Tyr Glu Leu Leu 
    290                 295                 300                 


Tyr Asn Cys Gly Ile Gln Leu Leu His Ile Gly Arg Pro Leu Ala Ala 
305                 310                 315                 320 


Phe Glu Cys Leu Ile Glu Ala Val Gln Val Tyr His Ala Asn Pro Arg 
                325                 330                 335     


Leu Trp Leu Arg Leu Ala Glu Cys Cys Ile Ala Ala Asn Lys Gly Xaa 
            340                 345                 350         


Ser Glu Gln Glu Xaa Lys Gly Leu Pro Ser Lys Lys Gly Ile Val Gln 
        355                 360                 365             


Ser Ile Val Gly Gln Gly Tyr His Arg Lys Ile Val Leu Ala Ser Gln 
    370                 375                 380                 


Ser Ile Gln Asn Xaa Val Tyr Asn Asp Gly Gln Ser Ser Ala Ile Pro 
385                 390                 395                 400 


Val Ala Ser Met Glu Phe Ala Ala Ile Cys Leu Arg Asn Ala Leu Leu 
                405                 410                 415     


Leu Leu Pro Glu Glu Gln Gln Asp Pro Lys Gln Glu Asn Gly Ala Lys 
            420                 425                 430         


Asn Ser Asn Gln Leu Gly Gly Asn Xaa Glu Ser Ser Glu Ser Ser Glu 
        435                 440                 445             


Xaa Cys Arg Cys Ser Ile Leu Ala Cys Ser Ala Tyr Val Ala Leu Ala 
    450                 455                 460                 


Leu Gly Asp Asn Leu Met Ala Leu Asn His Ala Asp Lys Leu Leu Gln 
465                 470                 475                 480 


Gln Pro Lys Leu Ser Gly Ser Leu Lys Phe Leu Gly His Leu Tyr Ala 
                485                 490                 495     


Ala Glu Ala Leu Ile Ser Leu Asp Arg Ile Ser Asp Ala Ile Xaa His 
            500                 505                 510         


Leu Asn Pro Glu Asn Val Xaa Asp Val Ser Leu Gly Ile Ser Ser Asn 
        515                 520                 525             


Glu Gln Asp Gln Gly Ser Asp Lys Gly Glu Asn Glu Ala Met Glu Ser 
    530                 535                 540                 


Ser Gly Lys Arg Ala Pro Gln Cys Tyr Pro Ser Ser Val Asn Ser Ala 
545                 550                 555                 560 


Arg Xaa Val Met Leu Phe Asn Leu Gly Ser Ala Tyr Cys Leu Arg Ser 
                565                 570                 575     


Glu Tyr Asp Lys Ala Arg Lys Cys Leu His Gln Ala Gln Trp Leu Met 
            580                 585                 590         


Pro Pro Ser Xaa Leu Gly Gly Arg Gly Arg Arg Ile Met Arg Ser Gly 
        595                 600                 605             


Val 
    


<210> 6521
<211> 804
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(800)
<223> Selenocysteine

<400> 6521
Met Lys Ser Ile Gly Val Lys Xaa Val Lys Val Cys Gly Ser Lys Ser 
1               5                   10                  15      


Ser Val Arg Ile Glu Gly Gln Pro Cys Ser Leu Gly Gln Ser Arg Arg 
            20                  25                  30          


Lys Val Lys Leu Met Gly Glu Arg Ser Tyr Xaa Leu Ser Ile Gly Asn 
        35                  40                  45              


Gly Asp Tyr Phe Trp Ala Asn Lys Glu Met Leu Trp Asp Tyr Val Gln 
    50                  55                  60                  


Xaa Leu Ser Asp Gln Gly Ala Glu Lys His Glu Gly Xaa Gly Gln Ser 
65                  70                  75                  80  


Ser Gly Ile Xaa Asp Gln Glu Lys Glu Leu Ser Xaa Asn Ala Phe Gln 
                85                  90                  95      


Ala Phe Xaa Ser Gly Asn Tyr Asp Ala Cys Leu Gln His Leu Ala Cys 
            100                 105                 110         


Leu Gln Asp Ile Asn Lys Asp Asp Tyr Lys Ile Ile Leu Asn Xaa Ala 
        115                 120                 125             


Val Ala Glu Phe Phe Lys Ser Asn Gln Xaa Xaa Xaa Asp Asn Leu Arg 
    130                 135                 140                 


Gln Xaa Leu Asn Gln Leu Lys Asn Gln Val His Ser Ala Val Glu Glu 
145                 150                 155                 160 


Met Asp Gly Leu Asp Asp Val Glu Asn Ser Met Leu Tyr Tyr Asn Gln 
                165                 170                 175     


Ala Val Ile Leu Tyr His Leu Arg Gln Tyr Xaa Glu Ala Ile Ser Val 
            180                 185                 190         


Gly Glu Lys Leu Tyr Gln Phe Ile Glu Pro Phe Glu Glu Lys Phe Ala 
        195                 200                 205             


Gln Ala Val Cys Phe Leu Leu Val Asp Leu Tyr Ile Leu Xaa Tyr Gln 
    210                 215                 220                 


Ala Glu Lys Ala Leu His Leu Leu Ala Val Leu Glu Lys Met Ile Ser 
225                 230                 235                 240 


Gln Gly Asn Asn Asn Lys Asn Gly Lys Asn Glu Xaa Gly Asn Asn Asn 
                245                 250                 255     


Asn Lys Asp Gly Ser Asn His Lys Ala Glu Ser Gly Ala Leu Ile Glu 
            260                 265                 270         


Ala Ala Lys Ser Lys Ile His Gln Tyr Lys Val Arg Ala Tyr Ile Gln 
        275                 280                 285             


Met Lys Ser Leu Lys Ala Cys Lys Arg Glu Ile Lys Ser Val Met Asn 
    290                 295                 300                 


Xaa Ala Gly Asn Ser Ala Pro Ser Leu Phe Leu Lys Ser Asn Phe Glu 
305                 310                 315                 320 


Tyr Leu Arg Gly Asn Tyr Arg Lys Ala Val Lys Leu Leu Asn Ser Ser 
                325                 330                 335     


Asn Ile Ala Glu His Pro Gly Phe Met Lys Xaa Gly Glu Cys Leu Arg 
            340                 345                 350         


Cys Met Phe Trp Asn Asn Leu Gly Cys Ile His Phe Ala Met Ser Lys 
        355                 360                 365             


His Asn Leu Gly Ile Phe Tyr Phe Lys Lys Ala Leu Gln Glu Asn Asp 
    370                 375                 380                 


Asn Val Cys Ala Gln Leu Ser Ala Gly Ser Xaa Asp Pro Gly Lys Lys 
385                 390                 395                 400 


Phe Ser Gly Arg Pro Met Cys Xaa Leu Leu Xaa Asn Lys Arg Tyr Glu 
                405                 410                 415     


Leu Leu Tyr Asn Cys Gly Ile Gln Leu Leu His Ile Gly Arg Pro Leu 
            420                 425                 430         


Ala Ala Phe Glu Cys Leu Ile Glu Ala Val Gln Val Tyr His Ala Asn 
        435                 440                 445             


Pro Arg Leu Trp Leu Arg Leu Ala Glu Cys Cys Ile Ala Ala Asn Lys 
    450                 455                 460                 


Gly Xaa Ser Glu Gln Glu Xaa Lys Gly Leu Pro Ser Lys Lys Gly Ile 
465                 470                 475                 480 


Val Gln Ser Ile Val Gly Gln Gly Tyr His Arg Lys Ile Val Leu Ala 
                485                 490                 495     


Ser Gln Ser Ile Gln Asn Xaa Val Tyr Asn Asp Gly Gln Ser Ser Ala 
            500                 505                 510         


Ile Pro Val Ala Ser Met Glu Phe Ala Ala Ile Cys Leu Arg Asn Ala 
        515                 520                 525             


Leu Leu Leu Leu Pro Glu Glu Gln Gln Asp Pro Lys Gln Glu Asn Gly 
    530                 535                 540                 


Ala Lys Asn Ser Asn Gln Leu Gly Gly Asn Xaa Glu Ser Ser Glu Ser 
545                 550                 555                 560 


Ser Glu Xaa Cys Ser Ser Lys Ser His Asp Gly Asp Lys Phe Ile Pro 
                565                 570                 575     


Ala Pro Pro Ser Ser Pro Leu Arg Lys Gln Glu Leu Glu Asn Leu Lys 
            580                 585                 590         


Cys Ser Ile Leu Ala Cys Ser Ala Tyr Val Ala Leu Ala Leu Gly Asp 
        595                 600                 605             


Asn Leu Met Ala Leu Asn His Ala Asp Lys Leu Leu Gln Gln Pro Lys 
    610                 615                 620                 


Leu Ser Gly Ser Leu Lys Phe Leu Gly His Leu Tyr Ala Ala Glu Ala 
625                 630                 635                 640 


Leu Ile Ser Leu Asp Arg Ile Ser Asp Ala Ile Xaa His Leu Asn Pro 
                645                 650                 655     


Glu Asn Val Xaa Asp Val Ser Leu Gly Ile Ser Ser Asn Glu Gln Asp 
            660                 665                 670         


Gln Gly Ser Asp Lys Gly Glu Asn Glu Ala Met Glu Ser Ser Gly Lys 
        675                 680                 685             


Arg Ala Pro Gln Cys Tyr Pro Ser Ser Val Asn Ser Ala Arg Xaa Val 
    690                 695                 700                 


Met Leu Phe Asn Leu Gly Ser Ala Tyr Cys Leu Arg Ser Glu Tyr Asp 
705                 710                 715                 720 


Lys Ala Arg Lys Cys Leu His Gln Ala Ala Ser Met Ile His Pro Lys 
                725                 730                 735     


Glu Val Pro Pro Glu Ala Ile Leu Leu Ala Val Tyr Leu Glu Leu Gln 
            740                 745                 750         


Asn Gly Asn Xaa Gln Leu Ala Leu Gln Ile Ile Lys Arg Asn Gln Leu 
        755                 760                 765             


Leu Pro Ala Val Lys Xaa His Ser Glu Val Arg Lys Lys Pro Val Phe 
    770                 775                 780                 


Gln Pro Val His Pro Ile Gln Pro Ile Gln Met Pro Ala Phe Xaa Xaa 
785                 790                 795                 800 


Val Gln Arg Lys 
                


<210> 6522
<211> 229
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<400> 6522
Pro Val Ala Ser Met Glu Phe Ala Ala Ile Cys Leu Arg Asn Ala Leu 
1               5                   10                  15      


Leu Leu Leu Pro Glu Glu Gln Gln Asp Pro Lys Gln Glu Asn Gly Ala 
            20                  25                  30          


Lys Asn Ser Asn Gln Leu Gly Gly Asn Xaa Glu Ser Ser Glu Ser Ser 
        35                  40                  45              


Glu Xaa Cys Ser Ser Lys Ser His Asp Gly Asp Lys Phe Ile Pro Ala 
    50                  55                  60                  


Pro Pro Ser Ser Pro Leu Arg Lys Gln Glu Leu Glu Asn Leu Lys Cys 
65                  70                  75                  80  


Ser Ile Leu Ala Cys Ser Ala Tyr Val Ala Leu Ala Leu Gly Asp Asn 
                85                  90                  95      


Leu Met Ala Leu Asn His Ala Asp Lys Leu Leu Gln Gln Pro Lys Leu 
            100                 105                 110         


Ser Gly Ser Leu Lys Phe Leu Gly His Leu Tyr Ala Ala Glu Ala Leu 
        115                 120                 125             


Ile Ser Leu Asp Arg Ile Ser Asp Ala Ile Xaa His Leu Asn Pro Glu 
    130                 135                 140                 


Asn Val Xaa Asp Val Ser Leu Gly Ile Ser Ser Asn Glu Gln Asp Gln 
145                 150                 155                 160 


Ala Gly Lys Arg Ala Pro Gln Cys Tyr Pro Ser Ser Val Asn Ser Ala 
                165                 170                 175     


Arg Xaa Val Met Leu Phe Asn Leu Gly Ser Ala Tyr Cys Leu Arg Ser 
            180                 185                 190         


Glu Tyr Asp Lys Ala Arg Lys Cys Leu His Gln Ala Ala Ser Met Ile 
        195                 200                 205             


His Pro Lys Glu Val Pro Pro Glu Ala Ile Leu Leu Ala Val Tyr Leu 
    210                 215                 220                 


Glu Leu Gln Asn Gly 
225                 


<210> 6523
<211> 210
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<400> 6523
Xaa Tyr Asp Ala Cys Leu Gln His Leu Ala Cys Leu Gln Asp Ile Asn 
1               5                   10                  15      


Lys Asp Asp Tyr Lys Ile Ile Leu Asn Xaa Ala Val Ala Glu Phe Phe 
            20                  25                  30          


Lys Ser Asn Gln Xaa Xaa Xaa Asp Asn Leu Arg Gln Xaa Leu Asn Gln 
        35                  40                  45              


Leu Lys Asn Gln Val His Ser Ala Val Glu Glu Met Asp Gly Leu Asp 
    50                  55                  60                  


Asp Val Glu Asn Ser Met Leu Tyr Tyr Asn Gln Ala Val Ile Leu Tyr 
65                  70                  75                  80  


His Leu Arg Gln Tyr Xaa Glu Ala Ile Ser Val Gly Glu Lys Leu Tyr 
                85                  90                  95      


Gln Phe Ile Glu Pro Phe Glu Glu Lys Phe Ala Gln Ala Val Cys Phe 
            100                 105                 110         


Leu Leu Val Asp Leu Tyr Ile Leu Xaa Tyr Gln Ala Glu Lys Ala Leu 
        115                 120                 125             


His Leu Leu Ala Val Leu Glu Lys Met Ile Ser Gln Gly Asn Asn Asn 
    130                 135                 140                 


Lys Asn Gly Lys Asn Glu Xaa Gly Asn Asn Asn Asn Lys Asp Gly Ser 
145                 150                 155                 160 


Asn His Lys Ala Glu Ser Gly Ala Leu Ile Glu Ala Ala Lys Ser Lys 
                165                 170                 175     


Ile His Gln Tyr Lys Val Arg Ala Tyr Ile Gln Met Lys Ser Leu Lys 
            180                 185                 190         


Ala Cys Lys Arg Glu Ile Lys Ser Val Met Asn Xaa Ala Gly Asn Val 
        195                 200                 205             


Asn Ala 
    210 


<210> 6524
<211> 510
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<400> 6524
Met Pro Gly Gly Gly Ala Ser Ala Ala Ser Gly Arg Leu Leu Xaa Ala 
1               5                   10                  15      


Ala Glu Gln Arg Gly Ser Arg Glu Ala Ala Gly Ser Ala Ser Arg Ser 
            20                  25                  30          


Gly Phe Gly Gly Ser Gly Gly Gly Arg Gly Gly Ala Ser Gly Pro Gly 
        35                  40                  45              


Ser Gly Ser Gly Gly Pro Gly Gly Pro Ala Gly Arg Met Ser Leu Xaa 
    50                  55                  60                  


Pro Lys Glu Leu Ser Ser Leu Leu Ser Ile Ile Ser Glu Glu Ala Gly 
65                  70                  75                  80  


Gly Gly Ser Xaa Phe Glu Gly Leu Ser Xaa Ala Phe His His Tyr Phe 
                85                  90                  95      


Ser Lys Ala Asp His Phe Arg Leu Gly Ser Val Leu Val Met Leu Leu 
            100                 105                 110         


Gln Gln Pro Asp Leu Leu Pro Ser Ala Ala Gln Arg Leu Xaa Ala Leu 
        115                 120                 125             


Tyr Leu Leu Trp Glu Met Tyr Arg Xaa Glu Pro Leu Ala Ala Asn Pro 
    130                 135                 140                 


Phe Ala Ala Ser Phe Ala His Leu Leu Asn Pro Ala Pro Pro Ala Arg 
145                 150                 155                 160 


Gly Gly Gln Glu Pro Asp Arg Pro Pro Leu Ser Gly Phe Leu Pro Pro 
                165                 170                 175     


Ile Xaa Pro Pro Glu Lys Phe Phe Leu Ser Gln Leu Met Leu Ala Pro 
            180                 185                 190         


Pro Arg Glu Leu Phe Lys Lys Xaa Pro Arg Gln Ile Ala Leu Met Asp 
        195                 200                 205             


Val Gly Asn Met Gly Gln Ser Val Asp Ile Ser Gly Leu Gln Leu Ala 
    210                 215                 220                 


Leu Ala Glu Arg Gln Ser Glu Leu Pro Xaa Gln Ser Lys Ala Ser Phe 
225                 230                 235                 240 


Pro Ser Ile Leu Ser Asp Pro Asp Pro Asp Ser Ser Asn Ser Gly Phe 
                245                 250                 255     


Asp Ser Ser Val Ala Ser Gln Ile Xaa Glu Ala Leu Val Ser Gly Pro 
            260                 265                 270         


Lys Pro Pro Ile Glu Ser His Phe Arg Pro Glu Phe Ile Arg Pro Pro 
        275                 280                 285             


Pro Pro Leu His Ile Cys Glu Asp Glu Leu Ala Trp Leu Asn Pro Xaa 
    290                 295                 300                 


Glu Pro Asp His Ala Ile Gln Trp Asp Lys Ser Met Cys Val Lys Asn 
305                 310                 315                 320 


Ser Xaa Gly Val Glu Ile Lys Arg Ile Met Ala Lys Ala Phe Lys Ser 
                325                 330                 335     


Pro Leu Ser Ser Pro Gln Gln Xaa Gln Leu Leu Gly Glu Leu Glu Lys 
            340                 345                 350         


Asp Pro Lys Leu Val Tyr His Ile Gly Leu Xaa Pro Ala Lys Leu Pro 
        355                 360                 365             


Asp Leu Val Glu Asn Asn Pro Leu Val Ala Ile Glu Met Leu Leu Lys 
    370                 375                 380                 


Leu Met Gln Ser Ser Gln Ile Xaa Glu Tyr Phe Ser Val Leu Val Asn 
385                 390                 395                 400 


Met Asp Met Ser Leu His Ser Met Glu Val Val Asn Arg Leu Xaa Xaa 
                405                 410                 415     


Ala Val Asp Leu Pro Pro Glu Phe Ile His Leu Tyr Ile Ser Asn Cys 
            420                 425                 430         


Ile Ser Xaa Cys Glu Gln Ile Lys Asp Lys Tyr Met Gln Asn Arg Leu 
        435                 440                 445             


Val Arg Leu Val Cys Val Phe Leu Gln Ser Leu Ile Arg Asn Lys Ile 
    450                 455                 460                 


Ile Asn Val Gln Asp Leu Phe Ile Glu Val Gln Ala Phe Cys Ile Glu 
465                 470                 475                 480 


Phe Ser Arg Ile Arg Glu Ala Ala Gly Leu Phe Arg Leu Leu Lys Xaa 
                485                 490                 495     


Leu Asp Xaa Gly Glu Xaa Pro Ser Glu Xaa Lys Met Ser Lys 
            500                 505                 510 


<210> 6525
<211> 127
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 6525
Xaa Xaa Gly Val Glu Ile Lys Arg Ile Met Ala Lys Ala Phe Lys Ser 
1               5                   10                  15      


Pro Leu Ser Ser Pro Gln Gln Xaa Gln Leu Leu Gly Glu Leu Glu Lys 
            20                  25                  30          


Asp Pro Lys Leu Val Tyr His Ile Gly Leu Xaa Pro Ala Lys Leu Pro 
        35                  40                  45              


Asp Leu Val Glu Asn Asn Pro Leu Val Ala Ile Glu Met Leu Leu Lys 
    50                  55                  60                  


Leu Met Gln Ser Ser Gln Ile Xaa Glu Tyr Phe Ser Val Leu Val Asn 
65                  70                  75                  80  


Met Asp Met Ser Leu His Ser Met Glu Val Val Asn Arg Leu Xaa Xaa 
                85                  90                  95      


Ala Val Asp Leu Pro Pro Glu Phe Ile His Leu Tyr Ile Ser Asn Cys 
            100                 105                 110         


Ile Ser Xaa Cys Glu Gln Ile Lys Asp Lys Tyr Met Gln Val Ile 
        115                 120                 125         


<210> 6526
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<400> 6526
Met Phe Gly Ala Ser Arg Lys Lys Phe Val Glu Gly Val Asp Ser Asp 
1               5                   10                  15      


Tyr His Asp Glu Asn Met Tyr Tyr Ser Gln Ser Ser Met Phe Pro His 
            20                  25                  30          


Arg Ser Glu Lys Asp Met Leu Ala Ser Pro Ser Xaa Ser Gly Gln Leu 
        35                  40                  45              


Ser Gln Phe Gly Ala Ser Leu Tyr Gly Gln Gln Ser Ala Leu Gly Leu 
    50                  55                  60                  


Pro Met Arg Gly Met Ser Asn Asn Xaa Pro Gln Leu Asn Arg Ser Leu 
65                  70                  75                  80  


Ser 
    


<210> 6527
<211> 196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<400> 6527
Met Phe Gly Ala Ser Arg Lys Lys Phe Val Glu Gly Val Asp Ser Asp 
1               5                   10                  15      


Tyr His Asp Glu Asn Met Tyr Tyr Ser Gln Ser Ser Met Phe Pro His 
            20                  25                  30          


Arg Ser Glu Lys Asp Met Leu Ala Ser Pro Ser Xaa Ser Gly Gln Leu 
        35                  40                  45              


Ser Gln Phe Gly Ala Ser Leu Tyr Gly Gln Gln Ser Ala Leu Gly Leu 
    50                  55                  60                  


Pro Met Arg Gly Met Ser Asn Asn Xaa Pro Gln Leu Asn Arg Ser Leu 
65                  70                  75                  80  


Ser Gln Gly Xaa Gln Leu Pro Ser His Val Xaa Pro Xaa Xaa Gly Val 
                85                  90                  95      


Pro Xaa Met Ser Leu His Xaa Pro Pro Ser Pro Ser Arg Gly Ile Leu 
            100                 105                 110         


Pro Met Asn Pro Arg Asn Met Met Asn His Ser Gln Val Gly Gln Gly 
        115                 120                 125             


Ile Gly Ile Pro Ser Arg Xaa Asn Ser Met Ser Ser Ser Gly Leu Gly 
    130                 135                 140                 


Ser Pro Asn Arg Ser Ser Pro Ser Ile Ile Cys Met Pro Lys Gln Gln 
145                 150                 155                 160 


Pro Ser Arg Gln Pro Phe Xaa Val Asn Ser Met Ser Gly Phe Gly Met 
                165                 170                 175     


Asn Arg Asn Gln Ala Phe Gly Met Asn Asn Ser Leu Ser Ser Asn Ile 
            180                 185                 190         


Phe Asn Gly Xaa 
        195     


<210> 6528
<211> 68
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<400> 6528
Met Leu Lys Glu Val Ala Gln Val Xaa Asn Ser Met Phe Gly Ala Ser 
1               5                   10                  15      


Arg Lys Lys Phe Val Glu Gly Val Asp Ser Asp Tyr His Asp Glu Asn 
            20                  25                  30          


Met Tyr Tyr Ser Gln Ser Ser Met Phe Pro His Arg Ser Glu Lys Asp 
        35                  40                  45              


Met Leu Ala Ser Pro Ser Xaa Ser Gly Gln Leu Ser Gln Phe Gly Ala 
    50                  55                  60                  


Ser Leu Tyr Gly 
65              


<210> 6529
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 6529
Met Leu Lys Glu Val Ala Gln Val Xaa Asn Ser Met Phe Gly Ala Ser 
1               5                   10                  15      


Arg Lys Lys Phe Val Glu Gly Val Asp Ser Asp Tyr His Asp Glu Asn 
            20                  25                  30          


Met Tyr Tyr Ser Gln Ser Ser Met Phe Pro His Arg Ser Glu Lys Asp 
        35                  40                  45              


Met Leu Ala Ser Pro Ser Xaa Ser Gly Gln Leu Ser Gln Phe Gly Ala 
    50                  55                  60                  


Ser Leu Tyr Gly Gln Gln Asn Gly Ser Glu Asn Val Xaa Gly Leu Asp 
65                  70                  75                  80  


Leu Ser Asp Phe Pro Ala Leu Ala Asp Arg Asn Arg Arg Glu Gly Ser 
                85                  90                  95      


Gly Asn Pro Xaa Pro Leu Ile Asn Pro Leu Ala Gly Arg Ala Pro Tyr 
            100                 105                 110         


Val Gly Met Val Xaa Lys Pro Ala Asn Glu Gln Ser Gln Asp Phe Ser 
        115                 120                 125             


Ile His Asn Glu Asp Phe Pro Ala Leu Pro Gly Ser Ser Tyr Lys Asp 
    130                 135                 140                 


<210> 6530
<211> 531
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<400> 6530
Met Leu Lys Glu Val Ala Gln Val Xaa Asn Ser Met Phe Gly Ala Ser 
1               5                   10                  15      


Arg Lys Lys Phe Val Glu Gly Val Asp Ser Asp Tyr His Asp Glu Asn 
            20                  25                  30          


Met Tyr Tyr Ser Gln Ser Ser Met Phe Pro His Arg Ser Glu Lys Asp 
        35                  40                  45              


Met Leu Ala Ser Pro Ser Xaa Ser Gly Gln Leu Ser Gln Phe Gly Ala 
    50                  55                  60                  


Ser Leu Tyr Gly Gln Gln Ser Ala Leu Gly Leu Pro Met Arg Gly Met 
65                  70                  75                  80  


Ser Asn Asn Xaa Pro Gln Leu Asn Arg Ser Leu Ser Gln Gly Xaa Gln 
                85                  90                  95      


Leu Pro Ser His Val Xaa Pro Xaa Xaa Gly Val Pro Xaa Met Ser Leu 
            100                 105                 110         


His Xaa Pro Pro Ser Pro Ser Arg Gly Ile Leu Pro Met Asn Pro Arg 
        115                 120                 125             


Asn Met Met Asn His Ser Gln Val Gly Gln Gly Ile Gly Ile Pro Ser 
    130                 135                 140                 


Arg Xaa Asn Ser Met Ser Ser Ser Gly Leu Gly Ser Pro Asn Arg Ser 
145                 150                 155                 160 


Ser Pro Ser Ile Ile Cys Met Pro Lys Gln Gln Pro Ser Arg Gln Pro 
                165                 170                 175     


Phe Xaa Val Asn Ser Met Ser Gly Phe Gly Met Asn Arg Asn Gln Ala 
            180                 185                 190         


Phe Gly Met Asn Asn Ser Leu Ser Ser Asn Ile Phe Asn Gly Xaa Asp 
        195                 200                 205             


Gly Ser Glu Asn Val Xaa Gly Leu Asp Leu Ser Asp Phe Pro Ala Leu 
    210                 215                 220                 


Ala Asp Arg Asn Arg Arg Glu Gly Ser Gly Asn Pro Xaa Pro Leu Ile 
225                 230                 235                 240 


Asn Pro Leu Ala Gly Arg Ala Pro Tyr Val Gly Met Val Xaa Lys Pro 
                245                 250                 255     


Ala Asn Glu Gln Ser Gln Asp Phe Ser Ile His Asn Glu Asp Phe Pro 
            260                 265                 270         


Ala Leu Pro Gly Ser Ser Tyr Lys Asp Pro Xaa Ser Ser Asn Asp Asp 
        275                 280                 285             


Ser Lys Ser Asn Leu Asn Xaa Ser Gly Lys Xaa Xaa Ser Ser Xaa Asp 
    290                 295                 300                 


Gly Pro Lys Phe Pro Gly Asp Lys Ser Ser Xaa Xaa Gln Asn Asn Asn 
305                 310                 315                 320 


Gln Gln Lys Lys Gly Ile Gln Val Leu Pro Asp Gly Arg Val Xaa Asn 
                325                 330                 335     


Ile Pro Gln Gly Met Val Xaa Asp Gln Phe Gly Met Ile Gly Leu Leu 
            340                 345                 350         


Xaa Phe Ile Arg Ala Ala Glu Xaa Asp Pro Gly Met Val His Leu Ala 
        355                 360                 365             


Leu Gly Ser Asp Leu Xaa Xaa Leu Gly Leu Asn Leu Asn Ser Pro Glu 
    370                 375                 380                 


Asn Leu Tyr Pro Lys Phe Ala Ser Pro Trp Ala Ser Ser Pro Cys Arg 
385                 390                 395                 400 


Pro Gln Asp Ile Asp Phe His Val Pro Ser Glu Tyr Leu Xaa Asn Ile 
                405                 410                 415     


His Ile Arg Asp Lys Leu Ala Ala Ile Lys Leu Gly Arg Tyr Gly Glu 
            420                 425                 430         


Asp Leu Leu Phe Tyr Leu Tyr Tyr Met Asn Gly Gly Asp Val Leu Gln 
        435                 440                 445             


Leu Leu Ala Ala Val Glu Leu Phe Asn Arg Asp Trp Arg Tyr His Lys 
    450                 455                 460                 


Glu Glu Arg Val Trp Ile Xaa Arg Ala Pro Gly Met Glu Pro Xaa Met 
465                 470                 475                 480 


Lys Xaa Asn Xaa Tyr Glu Arg Gly Xaa Tyr Tyr Phe Phe Asp Cys Leu 
                485                 490                 495     


Asn Trp Arg Lys Val Ala Lys Glu Phe His Leu Glu Tyr Asp Lys Leu 
            500                 505                 510         


Glu Glu Arg Pro His Leu Pro Ser Xaa Phe Asn Tyr Asn Pro Ala Gln 
        515                 520                 525             


Gln Ala Phe 
    530     


<210> 6531
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<400> 6531
Met Arg Gly Met Ser Asn Asn Xaa Pro Gln Leu Asn Arg Ser Leu Ser 
1               5                   10                  15      


Gln Gly Xaa Gln Leu Pro Ser His Val Xaa Pro Xaa Xaa Gly Val Pro 
            20                  25                  30          


Xaa Met Ser Leu His Xaa Pro Pro Ser Pro Ser Arg Gly Ile Leu Pro 
        35                  40                  45              


Met Asn Pro Arg Asn Met Met Asn His Ser Gln Val Gly Gln Gly Ile 
    50                  55                  60                  


Gly Ile Pro Ser Arg Xaa Asn Ser Met Ser Ser Ser Gly Leu Gly Ser 
65                  70                  75                  80  


Pro Asn Arg Ser Ser Pro Ser Ile Ile Cys Met Pro Lys Gln Gln Pro 
                85                  90                  95      


Ser Arg Gln Pro Phe Xaa Val Asn Ser Met Ser Gly Phe Gly Met Asn 
            100                 105                 110         


Arg Asn Gln Ala Phe Gly Met Asn Asn Ser Leu Ser Ser Asn Ile Phe 
        115                 120                 125             


Asn Gly Xaa 
    130     


<210> 6532
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<400> 6532
Met Val Arg Xaa Asp Gly His Xaa Leu Ser Glu Lys Arg Asn Tyr Gln 
1               5                   10                  15      


Pro Pro Ala Leu Ser Phe Pro Ile Pro Arg Val Ala Asn Val Glu Arg 
            20                  25                  30          


Ser Cys Xaa Asp Val Val Ser Leu Cys His Pro Gly Trp Xaa Ala Val 
        35                  40                  45              


Ala Ser Ser Trp Leu Xaa Ala Xaa Ser Ala Ser Gln Val Gln Val Ile 
    50                  55                  60                  


Leu Leu Pro Arg Pro Pro Ser Ser Trp Asp Tyr Arg 
65                  70                  75      


<210> 6533
<211> 54
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<400> 6533
Met Val Arg Xaa Asp Gly His Xaa Leu Ser Glu Lys Arg Asn Tyr Gln 
1               5                   10                  15      


Pro Pro Ala Leu Ser Phe Pro Ile Pro Arg Val Ala Asn Val Glu Arg 
            20                  25                  30          


Ser Cys Xaa Gly Asp Lys Gln His Val Trp Cys Phe Lys Lys Glu Val 
        35                  40                  45              


Cys Arg Gly Gly Arg Gln 
    50                  


<210> 6534
<211> 36
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<400> 6534
Met Val Arg Xaa Asp Gly His Xaa Leu Ser Glu Lys Arg Asn Tyr Gln 
1               5                   10                  15      


Ser Gly Arg Ile Pro Ser Phe Ile Met Phe Trp Leu Asp Phe Leu Xaa 
            20                  25                  30          


Val Cys Trp Ser 
        35      


<210> 6535
<211> 25
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<400> 6535
Met Val Arg Xaa Asp Gly His Xaa Leu Ser Glu Lys Arg Asn Tyr Gln 
1               5                   10                  15      


Val Xaa Asn Ser Met Phe Gly Ala Ser 
            20                  25  


<210> 6536
<211> 276
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(247)
<223> Selenocysteine

<400> 6536
Met Val Arg Xaa Asp Gly His Xaa Leu Ser Glu Lys Arg Asn Tyr Gln 
1               5                   10                  15      


Val Xaa Asn Ser Met Phe Gly Ala Ser Arg Lys Lys Phe Val Glu Gly 
            20                  25                  30          


Val Asp Ser Asp Tyr His Asp Glu Asn Met Tyr Tyr Ser Gln Ser Ser 
        35                  40                  45              


Met Phe Pro His Arg Ser Glu Lys Asp Met Leu Ala Ser Pro Ser Xaa 
    50                  55                  60                  


Ser Gly Gln Leu Ser Gln Phe Gly Ala Ser Leu Tyr Gly Gln Gln Asn 
65                  70                  75                  80  


Gly Ser Glu Asn Val Xaa Gly Leu Asp Leu Ser Asp Phe Pro Ala Leu 
                85                  90                  95      


Ala Asp Arg Asn Arg Arg Glu Gly Ser Gly Asn Pro Xaa Pro Leu Ile 
            100                 105                 110         


Asn Pro Leu Ala Gly Arg Ala Pro Tyr Val Gly Met Val Xaa Lys Pro 
        115                 120                 125             


Ala Asn Glu Gln Ser Gln Asp Phe Ser Ile His Asn Glu Asp Phe Pro 
    130                 135                 140                 


Ala Leu Pro Gly Ser Ser Tyr Lys Asp Pro Xaa Ser Ser Asn Asp Asp 
145                 150                 155                 160 


Ser Lys Ser Asn Leu Asn Xaa Ser Gly Lys Xaa Xaa Ser Ser Xaa Asp 
                165                 170                 175     


Gly Pro Lys Phe Pro Gly Asp Lys Ser Ser Xaa Xaa Gln Asn Asn Asn 
            180                 185                 190         


Gln Gln Lys Lys Gly Ile Gln Val Leu Pro Asp Gly Arg Val Xaa Asn 
        195                 200                 205             


Ile Pro Gln Gly Met Val Xaa Asp Gln Phe Gly Met Ile Gly Leu Leu 
    210                 215                 220                 


Xaa Phe Ile Arg Ala Ala Glu Xaa Asp Pro Gly Met Val His Leu Ala 
225                 230                 235                 240 


Leu Gly Ser Asp Leu Xaa Xaa Leu Gly Leu Asn Leu Asn Ser Pro Glu 
                245                 250                 255     


Asn Leu Tyr Pro Lys Phe Ala Ser Pro Trp Ala Ser Ser Pro Cys Arg 
            260                 265                 270         


Pro Gln Asp Ile 
        275     


<210> 6537
<211> 183
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<400> 6537
Met Val Arg Xaa Asp Gly His Xaa Leu Ser Glu Lys Arg Asn Tyr Gln 
1               5                   10                  15      


Val Xaa Asn Ser Met Phe Gly Ala Ser Arg Lys Lys Phe Val Glu Gly 
            20                  25                  30          


Val Asp Ser Asp Tyr His Asp Glu Asn Met Tyr Tyr Ser Gln Ser Ser 
        35                  40                  45              


Met Phe Pro His Arg Ser Glu Lys Asp Met Leu Ala Ser Pro Ser Xaa 
    50                  55                  60                  


Ser Gly Gln Leu Ser Gln Phe Gly Ala Ser Leu Tyr Gly Gln Gln Ser 
65                  70                  75                  80  


Ala Leu Gly Leu Pro Met Arg Gly Met Ser Asn Asn Xaa Pro Gln Leu 
                85                  90                  95      


Asn Arg Ser Leu Ser Gln Gly Xaa Gln Leu Pro Ser His Val Xaa Pro 
            100                 105                 110         


Xaa Xaa Gly Val Pro Xaa Met Ser Leu His Xaa Pro Pro Ser Pro Ser 
        115                 120                 125             


Arg Gly Ile Leu Pro Met Asn Pro Arg Asn Met Met Asn His Ser Gln 
    130                 135                 140                 


Val Gly Gln Gly Ile Gly Ile Pro Ser Arg Xaa Asn Ser Met Ser Ser 
145                 150                 155                 160 


Ser Gly Leu Gly Ser Pro Asn Arg Ser Ser Pro Ser Ile Ile Cys Met 
                165                 170                 175     


Pro Lys Gln Gln Pro Ser Arg 
            180             


<210> 6538
<211> 217
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<400> 6538
Met Val Arg Xaa Asp Gly His Xaa Leu Ser Glu Lys Arg Asn Tyr Gln 
1               5                   10                  15      


Val Xaa Asn Ser Met Phe Gly Ala Ser Arg Lys Lys Phe Val Glu Gly 
            20                  25                  30          


Val Asp Ser Asp Tyr His Asp Glu Asn Met Tyr Tyr Ser Gln Ser Ser 
        35                  40                  45              


Met Phe Pro His Arg Ser Glu Lys Asp Met Leu Ala Ser Pro Ser Xaa 
    50                  55                  60                  


Ser Gly Gln Leu Ser Gln Phe Gly Ala Ser Leu Tyr Gly Gln Gln Ser 
65                  70                  75                  80  


Ala Leu Gly Leu Pro Met Arg Gly Met Ser Asn Asn Xaa Pro Gln Leu 
                85                  90                  95      


Asn Arg Ser Leu Ser Gln Gly Xaa Gln Leu Pro Ser His Val Xaa Pro 
            100                 105                 110         


Xaa Xaa Gly Val Pro Xaa Met Ser Leu His Xaa Pro Pro Ser Pro Ser 
        115                 120                 125             


Arg Gly Ile Leu Pro Met Asn Pro Arg Asn Met Met Asn His Ser Gln 
    130                 135                 140                 


Val Gly Gln Gly Ile Gly Ile Pro Ser Arg Xaa Asn Ser Met Ser Ser 
145                 150                 155                 160 


Ser Gly Leu Gly Ser Pro Asn Arg Ser Ser Pro Ser Ile Ile Cys Met 
                165                 170                 175     


Pro Lys Gln Gln Pro Ser Arg Gln Pro Phe Xaa Val Asn Arg Asn Gln 
            180                 185                 190         


Ala Phe Gly Met Asn Asn Ser Leu Ser Ser Asn Ile Phe Asn Gly Xaa 
        195                 200                 205             


Asp Gly Ser Glu Asn Val Xaa Gly Leu 
    210                 215         


<210> 6539
<211> 540
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<400> 6539
Met Val Arg Xaa Asp Gly His Xaa Leu Ser Glu Lys Arg Asn Tyr Gln 
1               5                   10                  15      


Val Xaa Asn Ser Met Phe Gly Ala Ser Arg Lys Lys Phe Val Glu Gly 
            20                  25                  30          


Val Asp Ser Asp Tyr His Asp Glu Asn Met Tyr Tyr Ser Gln Ser Ser 
        35                  40                  45              


Met Phe Pro His Arg Ser Glu Lys Asp Met Leu Ala Ser Pro Ser Xaa 
    50                  55                  60                  


Ser Gly Gln Leu Ser Gln Phe Gly Ala Ser Leu Tyr Gly Gln Gln Ser 
65                  70                  75                  80  


Ala Leu Gly Leu Pro Met Arg Gly Met Ser Asn Asn Xaa Pro Gln Leu 
                85                  90                  95      


Asn Arg Ser Leu Ser Gln Gly Xaa Gln Leu Pro Ser His Val Xaa Pro 
            100                 105                 110         


Xaa Xaa Gly Val Pro Xaa Met Ser Leu His Xaa Pro Pro Ser Pro Ser 
        115                 120                 125             


Arg Gly Ile Leu Pro Met Asn Pro Arg Asn Met Met Asn His Ser Gln 
    130                 135                 140                 


Val Gly Gln Gly Ile Gly Ile Pro Ser Arg Xaa Asn Ser Met Ser Ser 
145                 150                 155                 160 


Ser Gly Leu Gly Ser Pro Asn Arg Ser Ser Pro Ser Ile Ile Cys Met 
                165                 170                 175     


Pro Lys Gln Gln Pro Ser Arg Gln Pro Phe Xaa Val Asn Ser Met Ser 
            180                 185                 190         


Gly Phe Gly Met Asn Arg Asn Gln Ala Phe Gly Met Asn Asn Ser Leu 
        195                 200                 205             


Ser Ser Asn Ile Phe Asn Gly Xaa Asp Gly Ser Glu Asn Val Xaa Gly 
    210                 215                 220                 


Leu Asp Leu Ser Asp Phe Pro Ala Leu Ala Asp Arg Asn Arg Arg Glu 
225                 230                 235                 240 


Gly Ser Gly Asn Pro Xaa Pro Leu Ile Asn Pro Leu Ala Gly Arg Ala 
                245                 250                 255     


Pro Tyr Val Gly Met Val Xaa Lys Pro Ala Asn Glu Gln Ser Gln Asp 
            260                 265                 270         


Phe Ser Ile His Asn Glu Asp Phe Pro Ala Leu Pro Gly Ser Ser Tyr 
        275                 280                 285             


Lys Asp Pro Xaa Ser Ser Asn Asp Asp Ser Lys Ser Asn Leu Asn Xaa 
    290                 295                 300                 


Ser Gly Lys Xaa Xaa Ser Ser Xaa Asp Gly Pro Lys Phe Pro Gly Asp 
305                 310                 315                 320 


Lys Ser Ser Xaa Xaa Gln Asn Asn Asn Gln Gln Lys Lys Gly Ile Gln 
                325                 330                 335     


Val Leu Pro Asp Gly Arg Val Xaa Asn Ile Pro Gln Gly Met Val Xaa 
            340                 345                 350         


Asp Gln Phe Gly Met Ile Gly Leu Leu Xaa Phe Ile Arg Ala Ala Glu 
        355                 360                 365             


Xaa Asp Pro Gly Met Val His Leu Ala Leu Gly Ser Asp Leu Xaa Xaa 
    370                 375                 380                 


Leu Gly Leu Asn Leu Asn Ser Pro Glu Asn Leu Tyr Pro Lys Phe Ala 
385                 390                 395                 400 


Ser Pro Trp Ala Ser Ser Pro Cys Arg Pro Gln Asp Ile Asp Phe His 
                405                 410                 415     


Val Pro Ser Glu Tyr Leu Xaa Asn Ile His Ile Arg Asp Lys Leu Ala 
            420                 425                 430         


Ala Ile Lys Leu Gly Arg Tyr Gly Glu Asp Leu Leu Phe Tyr Leu Tyr 
        435                 440                 445             


Tyr Met Asn Gly Gly Asp Val Leu Gln Leu Leu Ala Ala Val Glu Leu 
    450                 455                 460                 


Phe Asn Arg Asp Trp Arg Tyr His Lys Glu Glu Arg Val Trp Ile Xaa 
465                 470                 475                 480 


Arg Ala Pro Gly Met Glu Pro Xaa Met Lys Xaa Asn Xaa Tyr Glu Arg 
                485                 490                 495     


Gly Xaa Tyr Tyr Phe Phe Asp Cys Leu Asn Trp Arg Lys Val Ala Lys 
            500                 505                 510         


Glu Phe His Leu Glu Tyr Asp Lys Leu Glu Glu Arg Pro His Leu Pro 
        515                 520                 525             


Ser Xaa Phe Asn Tyr Asn Pro Ala Gln Gln Ala Phe 
    530                 535                 540 


<210> 6540
<211> 321
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<400> 6540
Met Val Arg Xaa Asp Gly His Xaa Leu Ser Glu Lys Arg Asn Tyr Gln 
1               5                   10                  15      


Val Xaa Asn Ser Met Phe Gly Ala Ser Arg Lys Lys Phe Val Glu Gly 
            20                  25                  30          


Val Asp Ser Asp Tyr His Asp Glu Asn Met Tyr Tyr Ser Gln Ser Ser 
        35                  40                  45              


Met Phe Pro His Arg Ser Glu Lys Asp Met Leu Ala Ser Pro Ser Xaa 
    50                  55                  60                  


Ser Gly Gln Leu Ser Gln Phe Gly Ala Ser Leu Tyr Gly Gln Gln Ser 
65                  70                  75                  80  


Ala Leu Gly Leu Pro Met Arg Gly Met Ser Asn Asn Xaa Pro Gln Leu 
                85                  90                  95      


Asn Arg Ser Leu Ser Gln Gly Xaa Gln Leu Pro Ser His Val Xaa Pro 
            100                 105                 110         


Xaa Xaa Gly Val Pro Xaa Met Ser Leu His Xaa Pro Pro Ser Pro Ser 
        115                 120                 125             


Arg Gly Ile Leu Pro Met Asn Pro Arg Asn Met Met Asn His Ser Gln 
    130                 135                 140                 


Val Gly Gln Gly Ile Gly Ile Pro Ser Arg Xaa Asn Ser Met Ser Ser 
145                 150                 155                 160 


Ser Gly Leu Gly Ser Pro Asn Arg Ser Ser Pro Ser Ile Ile Cys Met 
                165                 170                 175     


Pro Lys Gln Gln Pro Ser Arg Gln Pro Phe Xaa Val Asn Ser Met Ser 
            180                 185                 190         


Gly Phe Gly Met Asn Arg Asn Gln Ala Phe Gly Met Asn Asn Ser Leu 
        195                 200                 205             


Ser Ser Asn Ile Phe Asn Gly Xaa Asp Gly Ser Glu Asn Val Xaa Gly 
    210                 215                 220                 


Leu Asp Leu Ser Asp Phe Pro Ala Leu Ala Asp Arg Asn Arg Arg Glu 
225                 230                 235                 240 


Gly Ser Gly Asn Pro Xaa Pro Leu Ile Asn Pro Leu Ala Gly Arg Ala 
                245                 250                 255     


Pro Tyr Val Gly Met Val Xaa Lys Pro Ala Asn Glu Gln Ser Gln Asp 
            260                 265                 270         


Phe Ser Ile His Asn Glu Asp Phe Pro Ala Leu Pro Gly Ser Ser Tyr 
        275                 280                 285             


Lys Asp Pro Xaa Ser Ser Asn Asp Asp Ser Lys Ser Asn Leu Asn Xaa 
    290                 295                 300                 


Ser Gly Lys Xaa Xaa Ser Ser Xaa Asp Gly Pro Lys Phe Pro Gly Asp 
305                 310                 315                 320 


Lys 
    


<210> 6541
<211> 309
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<400> 6541
Met Val Arg Xaa Asp Gly His Xaa Leu Ser Glu Lys Arg Asn Tyr Gln 
1               5                   10                  15      


Val Xaa Asn Ser Met Phe Gly Ala Ser Arg Lys Lys Phe Val Glu Gly 
            20                  25                  30          


Val Asp Ser Asp Tyr His Asp Glu Asn Met Tyr Tyr Ser Gln Ser Ser 
        35                  40                  45              


Met Phe Pro His Arg Ser Glu Lys Asp Met Leu Ala Ser Pro Ser Xaa 
    50                  55                  60                  


Ser Gly Gln Leu Ser Gln Phe Gly Ala Ser Leu Tyr Gly Gln Gln Ser 
65                  70                  75                  80  


Ala Leu Gly Leu Pro Met Arg Gly Met Ser Asn Asn Xaa Pro Gln Leu 
                85                  90                  95      


Asn Arg Ser Leu Ser Gln Gly Xaa Gln Leu Pro Ser His Val Xaa Pro 
            100                 105                 110         


Xaa Xaa Gly Val Pro Xaa Met Ser Leu His Xaa Pro Pro Ser Pro Ser 
        115                 120                 125             


Ser Met Ser Gly Phe Gly Met Asn Arg Asn Gln Ala Phe Gly Met Asn 
    130                 135                 140                 


Asn Ser Leu Ser Ser Asn Ile Phe Asn Gly Xaa Asp Gly Ser Glu Asn 
145                 150                 155                 160 


Val Xaa Gly Leu Asp Leu Ser Asp Phe Pro Ala Leu Ala Asp Arg Asn 
                165                 170                 175     


Arg Arg Glu Gly Ser Gly Asn Pro Xaa Pro Leu Ile Asn Pro Leu Ala 
            180                 185                 190         


Gly Arg Ala Pro Tyr Val Gly Met Val Xaa Lys Pro Ala Asn Glu Gln 
        195                 200                 205             


Ser Gln Asp Phe Ser Ile His Asn Glu Asp Phe Pro Ala Leu Pro Gly 
    210                 215                 220                 


Ser Ser Tyr Lys Asp Pro Xaa Ser Ser Asn Asp Asp Ser Lys Ser Asn 
225                 230                 235                 240 


Leu Asn Xaa Ser Gly Lys Xaa Xaa Ser Ser Xaa Asp Gly Pro Lys Phe 
                245                 250                 255     


Pro Gly Asp Lys Ser Ser Xaa Xaa Gln Asn Asn Asn Gln Gln Lys Lys 
            260                 265                 270         


Gly Ile Gln Val Leu Pro Asp Gly Arg Val Xaa Asn Ile Pro Gln Gly 
        275                 280                 285             


Met Val Xaa Asp Gln Phe Gly Met Ile Gly Leu Leu Xaa Phe Ile Arg 
    290                 295                 300                 


Ala Ala Glu Xaa Asp 
305                 


<210> 6542
<211> 62
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<400> 6542
Met Val Arg Xaa Asp Gly His Xaa Leu Ser Glu Lys Arg Asn Tyr Gln 
1               5                   10                  15      


Val Xaa Asn Ser Met Phe Gly Ala Ser Arg Lys Lys Phe Val Glu Gly 
            20                  25                  30          


Val Asp Ser Asp Tyr His Asp Glu Asn Met Tyr Tyr Ser Gln Ser Ser 
        35                  40                  45              


Met Phe Pro His Arg Ser Glu Lys Asp Xaa Glu Val Lys Met 
    50                  55                  60          


<210> 6543
<211> 191
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<400> 6543
Met Val Xaa Asp Gln Phe Gly Met Ile Gly Leu Leu Xaa Phe Ile Arg 
1               5                   10                  15      


Ala Ala Glu Xaa Asp Pro Gly Met Val His Leu Ala Leu Gly Ser Asp 
            20                  25                  30          


Leu Xaa Xaa Leu Gly Leu Asn Leu Asn Ser Pro Glu Asn Leu Tyr Pro 
        35                  40                  45              


Lys Phe Ala Ser Pro Trp Ala Ser Ser Pro Cys Arg Pro Gln Asp Ile 
    50                  55                  60                  


Asp Phe His Val Pro Ser Glu Tyr Leu Xaa Asn Ile His Ile Arg Asp 
65                  70                  75                  80  


Lys Leu Ala Ala Ile Lys Leu Gly Arg Tyr Gly Glu Asp Leu Leu Phe 
                85                  90                  95      


Tyr Leu Tyr Tyr Met Asn Gly Gly Asp Val Leu Gln Leu Leu Ala Ala 
            100                 105                 110         


Val Glu Leu Phe Asn Arg Asp Trp Arg Tyr His Lys Glu Glu Arg Val 
        115                 120                 125             


Trp Ile Xaa Arg Ala Pro Gly Met Glu Pro Xaa Met Lys Xaa Asn Xaa 
    130                 135                 140                 


Tyr Glu Arg Gly Xaa Tyr Tyr Phe Phe Asp Cys Leu Asn Trp Arg Lys 
145                 150                 155                 160 


Val Ala Lys Glu Phe His Leu Glu Tyr Asp Lys Leu Glu Glu Arg Pro 
                165                 170                 175     


His Leu Pro Ser Xaa Phe Asn Tyr Asn Pro Ala Gln Gln Ala Phe 
            180                 185                 190     


<210> 6544
<211> 104
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 6544
Pro Ser Glu Tyr Leu Xaa Asn Ile His Ile Arg Asp Lys Leu Ala Ala 
1               5                   10                  15      


Ile Lys Leu Gly Arg Tyr Gly Glu Asp Leu Leu Phe Tyr Leu Tyr Tyr 
            20                  25                  30          


Met Asn Gly Gly Asp Val Leu Gln Leu Leu Ala Ala Val Glu Leu Phe 
        35                  40                  45              


Asn Arg Asp Trp Arg Tyr His Lys Glu Glu Arg Val Trp Ile Xaa Arg 
    50                  55                  60                  


Ala Pro Gly Met Glu Pro Xaa Met Lys Xaa Asn Xaa Tyr Glu Arg Gly 
65                  70                  75                  80  


Xaa Tyr Tyr Phe Phe Asp Cys Leu Asn Trp Arg Lys Val Ala Lys Val 
                85                  90                  95      


Tyr Phe Phe Pro Cys Ala Asn Val 
            100                 


<210> 6545
<211> 152
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<400> 6545
Xaa Glu Asn Met Tyr Tyr Ser Gln Ser Ser Met Phe Pro His Arg Ser 
1               5                   10                  15      


Glu Lys Asp Met Leu Ala Ser Pro Ser Xaa Ser Gly Gln Leu Ser Gln 
            20                  25                  30          


Phe Gly Ala Ser Leu Tyr Gly Gln Gln Ser Ala Leu Gly Leu Pro Met 
        35                  40                  45              


Arg Gly Met Ser Asn Asn Xaa Pro Gln Leu Asn Arg Ser Leu Ser Gln 
    50                  55                  60                  


Gly Xaa Gln Leu Pro Ser His Val Xaa Pro Xaa Xaa Gly Val Pro Xaa 
65                  70                  75                  80  


Met Ser Leu His Xaa Pro Pro Ser Pro Ser Arg Gly Ile Leu Pro Met 
                85                  90                  95      


Asn Pro Arg Asn Met Met Asn His Ser Gln Val Gly Gln Gly Ile Gly 
            100                 105                 110         


Ile Pro Ser Arg Xaa Asn Ser Met Ser Ser Ser Gly Leu Gly Ser Pro 
        115                 120                 125             


Asn Arg Ser Ser Pro Ser Ile Ile Cys Met Pro Lys Gln Gln Pro Ser 
    130                 135                 140                 


Arg Gln Pro Phe Xaa Val Asn Arg 
145                 150         


<210> 6546
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 6546
Xaa His Leu Ala Leu Gly Ser Asp Leu Xaa Xaa Leu Gly Leu Asn Leu 
1               5                   10                  15      


Asn Ser Pro Glu Asn Leu Tyr Pro Lys Phe Ala Ser Pro Trp Ala Ser 
            20                  25                  30          


Ser Pro Cys Arg Pro Gln Asp Ile Asp Phe His Val Pro Ser Glu Tyr 
        35                  40                  45              


Leu Xaa Asn Ile His Ile Arg Asp Lys Leu Ala Ala Ile Lys Leu Gly 
    50                  55                  60                  


Arg Tyr Gly Glu Asp Leu Leu Phe Tyr Leu Tyr Tyr Met Asn Gly Gly 
65                  70                  75                  80  


Asp Val Leu Gln Leu Leu Ala Ala Val Glu Leu Ser Ser Ile Trp Asn 
                85                  90                  95      


Met Xaa Asn 
            


<210> 6547
<211> 46
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<400> 6547
Xaa Leu Tyr Pro Lys Phe Ala Ser Pro Trp Ala Ser Ser Pro Cys Arg 
1               5                   10                  15      


Pro Gln Asp Ile Asp Phe His Val Pro Ser Glu Tyr Leu Xaa Asn Ile 
            20                  25                  30          


His Ile Arg Asp Lys Leu Phe Phe Phe Phe Ser Trp Leu Gln 
        35                  40                  45      


<210> 6548
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<400> 6548
Xaa Pro Xaa Ser Ser Asn Asp Asp Ser Lys Ser Asn Leu Asn Xaa Ser 
1               5                   10                  15      


Gly Lys Xaa Xaa Ser Ser Xaa Asp Gly Pro Lys Phe Pro Gly Asp Lys 
            20                  25                  30          


Ser Ser Xaa Xaa Gln Asn Asn Asn Gln Gln Lys Lys Gly Ile Gln Val 
        35                  40                  45              


Leu Pro Asp Gly Arg Val Xaa Asn Ile Pro Gln Gly Met Val Xaa Asp 
    50                  55                  60                  


Gln Phe Gly Met Ile Gly Leu Leu Xaa Phe Ile Arg Ala Ala Glu Xaa 
65                  70                  75                  80  


Asp Pro Gly Met Val His Leu Ala Leu Gly Ser Asp Leu Xaa Xaa Leu 
                85                  90                  95      


Gly Leu Asn Leu Asn Ser Pro Glu Asn Leu Tyr Pro Lys Phe Ala Ser 
            100                 105                 110         


Pro Trp Ala Ser Ser Pro Cys Arg Pro Gln Asp Ile Asp Phe His Val 
        115                 120                 125             


Pro Ser Glu Tyr Leu Xaa Asn Ile His Ile Arg Asp Lys Leu Ala Ala 
    130                 135                 140                 


Ile Lys Leu Gly Arg Tyr Gly Glu Asp Leu Leu Phe Tyr Leu Tyr Tyr 
145                 150                 155                 160 


Met Asn Gly Gly Asp Val Leu Gln Leu Leu Ala Ala Val Glu Leu Tyr 
                165                 170                 175     


Val Gln Ser Ile Leu Ile Xaa Phe Val Leu 
            180                 185     


<210> 6549
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(166)
<223> Selenocysteine

<400> 6549
Xaa Xaa Asp Gly Pro Lys Phe Pro Gly Asp Lys Ser Ser Xaa Xaa Gln 
1               5                   10                  15      


Asn Asn Asn Gln Gln Lys Lys Gly Ile Gln Val Leu Pro Asp Gly Arg 
            20                  25                  30          


Val Xaa Asn Ile Pro Gln Gly Met Val Xaa Asp Gln Phe Gly Met Ile 
        35                  40                  45              


Gly Leu Leu Xaa Phe Ile Arg Ala Ala Glu Xaa Asp Pro Gly Met Val 
    50                  55                  60                  


His Leu Ala Leu Gly Ser Asp Leu Xaa Xaa Leu Gly Leu Asn Leu Asn 
65                  70                  75                  80  


Ser Pro Glu Asn Leu Tyr Pro Lys Phe Ala Ser Pro Trp Ala Ser Ser 
                85                  90                  95      


Pro Cys Arg Pro Gln Asp Ile Asp Phe His Val Pro Ser Glu Tyr Leu 
            100                 105                 110         


Xaa Asn Ile His Ile Arg Asp Lys Leu Ala Ala Ile Lys Leu Gly Arg 
        115                 120                 125             


Tyr Gly Glu Asp Leu Leu Phe Tyr Leu Tyr Tyr Met Asn Gly Gly Asp 
    130                 135                 140                 


Val Leu Gln Leu Leu Ala Ala Val Glu Leu Tyr Val Gln Ile Leu Xaa 
145                 150                 155                 160 


Val Ile Gly Asp Xaa Xaa Lys Lys Asn Glu Tyr Gly Leu Pro Gly His 
                165                 170                 175     


Gln Ala Trp Ser Gln Gln 
            180         


<210> 6550
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<400> 6550
Ala Gln Tyr Leu Ala Ala Lys Ala Leu Lys Lys Gln Ser Trp Arg Phe 
1               5                   10                  15      


His Xaa Lys Tyr Met Met Trp Phe Gln Arg His Glu Glu Pro Lys Xaa 
            20                  25                  30          


Ile Xaa Asp Glu Phe Glu Gln Ile Pro Asp His Leu Leu Val His Ser 
        35                  40                  45              


Leu Xaa Ala Phe Ser Pro Gly Gln Gly Xaa Tyr Ile Tyr Phe Asp Tyr 
    50                  55                  60                  


Glu Lys Trp Gly Gln Arg Lys Lys Glu Gly Phe Xaa Phe Glu Tyr Arg 
65                  70                  75                  80  


Tyr Leu Glu Asp Arg Asp Leu Gln 
                85              


<210> 6551
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 6551
Glu Phe Tyr Gln Arg Leu Ser Xaa Glu Xaa Leu Phe Phe Ile Phe Tyr 
1               5                   10                  15      


Tyr Leu Glu Gly Xaa Lys Ala Gln Tyr Leu Ala Ala Lys Ala Leu Lys 
            20                  25                  30          


Lys Gln Ser Trp Arg Phe His Xaa Lys Tyr Met Met Trp Phe Gln Arg 
        35                  40                  45              


His Glu Glu Pro Lys Xaa Ile Xaa Asp Glu Phe Glu Gln Gly Xaa Tyr 
    50                  55                  60                  


Ile Tyr Phe Asp Tyr Glu Lys Trp Gly Gln Arg Lys Lys Glu Gly Phe 
65                  70                  75                  80  


Xaa Phe Glu Tyr Arg Tyr Leu Glu Asp Arg Asp Leu Gln 
                85                  90              


<210> 6552
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<400> 6552
Glu Phe Tyr Gln Arg Leu Ser Xaa Glu Xaa Leu Phe Phe Ile Phe Tyr 
1               5                   10                  15      


Tyr Leu Glu Gly Xaa Lys Ala Gln Tyr Leu Ala Ala Lys Ala Leu Lys 
            20                  25                  30          


Lys Gln Ser Trp Arg Phe His Xaa Lys Tyr Met Met Trp Phe Gln Arg 
        35                  40                  45              


His Glu Glu Pro Lys Xaa Ile Xaa Asp Glu Phe Glu Gln Leu Ala Gln 
    50                  55                  60                  


Ser Leu Ser Leu Xaa Lys Tyr Ser Ser Leu Trp Leu Ser Ala Gln Pro 
65                  70                  75                  80  


Gly Xaa Pro Pro Ser His Pro Pro Leu Gly Gln Leu Leu Gly Leu Leu 
                85                  90                  95      


<210> 6553
<211> 753
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<400> 6553
Met Ala Asp Lys Arg Lys Leu Gln Gly Glu Ile Asp Arg Cys Leu Lys 
1               5                   10                  15      


Lys Val Ser Glu Gly Val Glu Gln Phe Glu Asp Ile Trp Gln Lys Leu 
            20                  25                  30          


His Asn Ala Ala Asn Ala Asn Gln Lys Glu Lys Tyr Glu Ala Asp Leu 
        35                  40                  45              


Lys Lys Glu Ile Lys Lys Leu Gln Arg Leu Arg Asp Gln Ile Lys Xaa 
    50                  55                  60                  


Trp Val Ala Ser Asn Glu Ile Lys Asp Lys Arg Gln Leu Ile Asp Asn 
65                  70                  75                  80  


Arg Lys Leu Ile Glu Xaa Gln Met Glu Arg Phe Lys Val Val Glu Arg 
                85                  90                  95      


Glu Xaa Lys Xaa Lys Ala Tyr Ser Lys Glu Gly Leu Gly Leu Ala Gln 
            100                 105                 110         


Lys Val Asp Pro Ala Gln Lys Glu Lys Glu Glu Val Gly Gln Trp Leu 
        115                 120                 125             


Xaa Asn Xaa Ile Asp Xaa Leu Asn Met Gln Val Asp Gln Phe Glu Ser 
    130                 135                 140                 


Glu Val Glu Ser Leu Ser Val Gln Xaa Arg Lys Lys Lys Gly Asp Lys 
145                 150                 155                 160 


Asp Lys Gln Asp Arg Ile Glu Gly Leu Lys Arg His Ile Glu Lys His 
                165                 170                 175     


Arg Tyr His Val Arg Met Leu Glu Xaa Ile Leu Arg Met Leu Asp Asn 
            180                 185                 190         


Asp Ser Ile Leu Val Asp Ala Ile Arg Lys Ile Lys Asp Asp Val Glu 
        195                 200                 205             


Tyr Tyr Val Asp Ser Ser Gln Asp Pro Asp Phe Glu Glu Asn Glu Phe 
    210                 215                 220                 


Leu Tyr Asp Asp Leu Asp Leu Glu Asp Ile Pro Gln Ala Leu Val Ala 
225                 230                 235                 240 


Xaa Ser Pro Pro Ser His Ser His Met Glu Asp Glu Ile Phe Asn Gln 
                245                 250                 255     


Ser Ser Ser Xaa Pro Xaa Ser Xaa Xaa Ser Ser Ser Pro Ile Pro Pro 
            260                 265                 270         


Ser Pro Ala Asn Cys Xaa Xaa Glu Asn Ser Glu Asp Asp Lys Lys Arg 
        275                 280                 285             


Gly Arg Ser Xaa Asp Ser Glu Val Ser Gln Ser Pro Ala Lys Asn Gly 
    290                 295                 300                 


Ser Lys Pro Val His Ser Asn Gln His Pro Gln Ser Pro Ala Val Pro 
305                 310                 315                 320 


Pro Xaa Tyr Pro Ser Gly Pro Pro Pro Ala Ala Ser Ala Leu Ser Xaa 
                325                 330                 335     


Xaa Pro Gly Asn Asn Gly Val Pro Ala Pro Ala Ala Pro Pro Ser Ala 
            340                 345                 350         


Leu Gly Pro Lys Ala Ser Pro Ala Pro Ser His Asn Ser Gly Xaa Pro 
        355                 360                 365             


Ala Pro Tyr Ala Gln Ala Val Ala Pro Pro Ala Pro Ser Gly Pro Ser 
    370                 375                 380                 


Xaa Xaa Gln Pro Arg Pro Pro Ser Val Gln Pro Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Ser Ser Ser Ser Asn Ser Ser Ala 
                405                 410                 415     


Gly Gly Gly Ala Gly Lys Gln Asn Gly Ala Xaa Ser Tyr Ser Ser Val 
            420                 425                 430         


Val Ala Asp Ser Pro Ala Glu Val Ala Leu Ser Ser Ser Gly Gly Asn 
        435                 440                 445             


Asn Ala Ser Ser Gln Ala Leu Gly Pro Pro Ser Gly Pro His Asn Pro 
    450                 455                 460                 


Pro Pro Ser Xaa Ser Lys Glu Pro Ser Ala Ala Ala Pro Xaa Gly Ala 
465                 470                 475                 480 


Gly Gly Val Ala Pro Gly Ser Gly Asn Asn Ser Gly Gly Pro Ser Leu 
                485                 490                 495     


Leu Val Pro Leu Pro Val Asn Pro Pro Ser Ser Pro Xaa Pro Ser Phe 
            500                 505                 510         


Ser Asp Ala Lys Ala Ala Gly Ala Leu Leu Asn Gly Pro Pro Gln Phe 
        515                 520                 525             


Ser Xaa Ala Pro Glu Ile Lys Ala Pro Glu Pro Leu Ser Ser Leu Lys 
    530                 535                 540                 


Ser Met Ala Glu Arg Ala Ala Ile Ser Ser Gly Ile Glu Asp Pro Val 
545                 550                 555                 560 


Pro Xaa Leu His Leu Xaa Glu Arg Asp Ile Ile Leu Ser Ser Xaa Ser 
                565                 570                 575     


Ala Pro Pro Ala Ser Ala Gln Pro Pro Leu Gln Leu Ser Glu Val Asn 
            580                 585                 590         


Ile Pro Leu Ser Leu Gly Val Cys Pro Leu Gly Pro Val Pro Leu Xaa 
        595                 600                 605             


Lys Glu Gln Leu Tyr Gln Gln Ala Met Glu Glu Ala Ala Trp His His 
    610                 615                 620                 


Met Pro His Pro Ser Asp Ser Glu Arg Ile Arg Gln Tyr Leu Pro Arg 
625                 630                 635                 640 


Asn Pro Cys Pro Xaa Pro Pro Tyr His His Gln Met Pro Pro Pro His 
                645                 650                 655     


Ser Asp Xaa Val Glu Phe Tyr Gln Arg Leu Ser Xaa Glu Xaa Leu Phe 
            660                 665                 670         


Phe Ile Phe Tyr Tyr Leu Glu Gly Xaa Lys Ala Gln Tyr Leu Ala Ala 
        675                 680                 685             


Lys Ala Leu Lys Lys Gln Ser Trp Arg Phe His Xaa Lys Tyr Met Met 
    690                 695                 700                 


Trp Phe Gln Arg His Glu Glu Pro Lys Xaa Ile Xaa Asp Glu Phe Glu 
705                 710                 715                 720 


Gln Gly Xaa Tyr Ile Tyr Phe Asp Tyr Glu Lys Trp Gly Gln Arg Lys 
                725                 730                 735     


Lys Glu Gly Phe Xaa Phe Glu Tyr Arg Tyr Leu Glu Asp Arg Asp Leu 
            740                 745                 750         


Gln 
    


<210> 6554
<211> 571
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<400> 6554
Met Leu Glu Xaa Ile Leu Arg Met Leu Asp Asn Asp Ser Ile Leu Val 
1               5                   10                  15      


Asp Ala Ile Arg Lys Ile Lys Asp Asp Val Glu Tyr Tyr Val Asp Ser 
            20                  25                  30          


Ser Gln Asp Pro Asp Phe Glu Glu Asn Glu Phe Leu Tyr Asp Asp Leu 
        35                  40                  45              


Asp Leu Glu Asp Ile Pro Gln Ala Leu Val Ala Xaa Ser Pro Pro Ser 
    50                  55                  60                  


His Ser His Met Glu Asp Glu Ile Phe Asn Gln Ser Ser Ser Xaa Pro 
65                  70                  75                  80  


Xaa Ser Xaa Xaa Ser Ser Ser Pro Ile Pro Pro Ser Pro Ala Asn Cys 
                85                  90                  95      


Xaa Xaa Glu Asn Ser Glu Asp Asp Lys Lys Arg Gly Arg Ser Xaa Asp 
            100                 105                 110         


Ser Glu Val Ser Gln Ser Pro Ala Lys Asn Gly Ser Lys Pro Val His 
        115                 120                 125             


Ser Asn Gln His Pro Gln Ser Pro Ala Val Pro Pro Xaa Tyr Pro Ser 
    130                 135                 140                 


Gly Pro Pro Pro Ala Ala Ser Ala Leu Ser Xaa Xaa Pro Gly Asn Asn 
145                 150                 155                 160 


Gly Val Pro Ala Pro Ala Ala Pro Pro Ser Ala Leu Gly Pro Lys Ala 
                165                 170                 175     


Ser Pro Ala Pro Ser His Asn Ser Gly Xaa Pro Ala Pro Tyr Ala Gln 
            180                 185                 190         


Ala Val Ala Pro Pro Ala Pro Ser Gly Pro Ser Xaa Xaa Gln Pro Arg 
        195                 200                 205             


Pro Pro Ser Val Gln Pro Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Ser Ser Ser Ser Asn Ser Ser Ala Gly Gly Gly Ala Gly 
225                 230                 235                 240 


Lys Gln Asn Gly Ala Xaa Ser Tyr Ser Ser Val Val Ala Asp Ser Pro 
                245                 250                 255     


Ala Glu Val Ala Leu Ser Ser Ser Gly Gly Asn Asn Ala Ser Ser Gln 
            260                 265                 270         


Ala Leu Gly Pro Pro Ser Gly Pro His Asn Pro Pro Pro Ser Xaa Ser 
        275                 280                 285             


Lys Glu Pro Ser Ala Ala Ala Pro Xaa Gly Ala Gly Gly Val Ala Pro 
    290                 295                 300                 


Gly Ser Gly Asn Asn Ser Gly Gly Pro Ser Leu Leu Val Pro Leu Pro 
305                 310                 315                 320 


Val Asn Pro Pro Ser Ser Pro Xaa Pro Ser Phe Ser Asp Ala Lys Ala 
                325                 330                 335     


Ala Gly Ala Leu Leu Asn Gly Pro Pro Gln Phe Ser Xaa Ala Pro Glu 
            340                 345                 350         


Ile Lys Ala Pro Glu Pro Leu Ser Ser Leu Lys Ser Met Ala Glu Arg 
        355                 360                 365             


Ala Ala Ile Ser Ser Gly Ile Glu Asp Pro Val Pro Xaa Leu His Leu 
    370                 375                 380                 


Xaa Glu Arg Asp Ile Ile Leu Ser Ser Xaa Ser Ala Pro Pro Ala Ser 
385                 390                 395                 400 


Ala Gln Pro Pro Leu Gln Leu Ser Glu Val Asn Ile Pro Leu Ser Leu 
                405                 410                 415     


Gly Val Cys Pro Leu Gly Pro Val Pro Leu Xaa Lys Glu Gln Leu Tyr 
            420                 425                 430         


Gln Gln Ala Met Glu Glu Ala Ala Trp His His Met Pro His Pro Ser 
        435                 440                 445             


Asp Ser Glu Arg Ile Arg Gln Tyr Leu Pro Arg Asn Pro Cys Pro Xaa 
    450                 455                 460                 


Pro Pro Tyr His His Gln Met Pro Pro Pro His Ser Asp Xaa Val Glu 
465                 470                 475                 480 


Phe Tyr Gln Arg Leu Ser Xaa Glu Xaa Leu Phe Phe Ile Phe Tyr Tyr 
                485                 490                 495     


Leu Glu Pro Arg Asp Val Arg Xaa Ala Trp Val Asp Ser Glu Ala Gly 
            500                 505                 510         


Pro Leu Arg His Xaa Ser Ala Pro Leu Pro Val Ala His Trp Leu Xaa 
        515                 520                 525             


Arg Gly Pro Ser Pro Ala Leu Leu Gln Gln Pro Gln Ser Arg Pro Xaa 
    530                 535                 540                 


Pro Leu Cys Ser Leu Ala His Ser Gln Ala Ser Leu Glu Xaa Xaa Gly 
545                 550                 555                 560 


Glu Leu Ser Ser Pro Leu Pro Xaa Pro Leu Leu 
                565                 570     


<210> 6555
<211> 571
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<400> 6555
Met Leu Glu Xaa Ile Leu Arg Met Leu Asp Asn Asp Ser Ile Leu Val 
1               5                   10                  15      


Asp Ala Ile Arg Lys Ile Lys Asp Asp Val Glu Tyr Tyr Val Asp Ser 
            20                  25                  30          


Ser Gln Asp Pro Asp Phe Glu Glu Asn Glu Phe Leu Tyr Asp Asp Leu 
        35                  40                  45              


Asp Leu Glu Asp Ile Pro Gln Ala Leu Val Ala Xaa Ser Pro Pro Ser 
    50                  55                  60                  


His Ser His Met Glu Asp Glu Ile Phe Asn Gln Ser Ser Ser Xaa Pro 
65                  70                  75                  80  


Xaa Ser Xaa Xaa Ser Ser Ser Pro Ile Pro Pro Ser Pro Ala Asn Cys 
                85                  90                  95      


Xaa Xaa Glu Asn Ser Glu Asp Asp Lys Lys Arg Gly Arg Ser Xaa Asp 
            100                 105                 110         


Ser Glu Val Ser Gln Ser Pro Ala Lys Asn Gly Ser Lys Pro Val His 
        115                 120                 125             


Ser Asn Gln His Pro Gln Ser Pro Ala Val Pro Pro Xaa Tyr Pro Ser 
    130                 135                 140                 


Gly Pro Pro Pro Ala Ala Ser Ala Leu Ser Xaa Xaa Pro Gly Asn Asn 
145                 150                 155                 160 


Gly Val Pro Ala Pro Ala Ala Pro Pro Ser Ala Leu Gly Pro Lys Ala 
                165                 170                 175     


Ser Pro Ala Pro Ser His Asn Ser Gly Xaa Pro Ala Pro Tyr Ala Gln 
            180                 185                 190         


Ala Val Ala Pro Pro Ala Pro Ser Gly Pro Ser Xaa Xaa Gln Pro Arg 
        195                 200                 205             


Pro Pro Ser Val Gln Pro Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly 
    210                 215                 220                 


Gly Gly Ser Ser Ser Ser Ser Asn Ser Ser Ala Gly Gly Gly Ala Gly 
225                 230                 235                 240 


Lys Gln Asn Gly Ala Xaa Ser Tyr Ser Ser Val Val Ala Asp Ser Pro 
                245                 250                 255     


Ala Glu Val Ala Leu Ser Ser Ser Gly Gly Asn Asn Ala Ser Ser Gln 
            260                 265                 270         


Ala Leu Gly Pro Pro Ser Gly Pro His Asn Pro Pro Pro Ser Xaa Ser 
        275                 280                 285             


Lys Glu Pro Ser Ala Ala Ala Pro Xaa Gly Ala Gly Gly Val Ala Pro 
    290                 295                 300                 


Gly Ser Gly Asn Asn Ser Gly Gly Pro Ser Leu Leu Val Pro Leu Pro 
305                 310                 315                 320 


Val Asn Pro Pro Ser Ser Pro Xaa Pro Ser Phe Ser Asp Ala Lys Ala 
                325                 330                 335     


Ala Gly Ala Leu Leu Asn Gly Pro Pro Gln Phe Ser Xaa Ala Pro Glu 
            340                 345                 350         


Ile Lys Ala Pro Glu Pro Leu Ser Ser Leu Lys Ser Met Ala Glu Arg 
        355                 360                 365             


Ala Ala Ile Ser Ser Gly Ile Glu Asp Pro Val Pro Xaa Leu His Leu 
    370                 375                 380                 


Xaa Glu Arg Asp Ile Ile Leu Ser Ser Xaa Ser Ala Pro Pro Ala Ser 
385                 390                 395                 400 


Ala Gln Pro Pro Leu Gln Leu Ser Glu Val Asn Ile Pro Leu Ser Leu 
                405                 410                 415     


Gly Val Cys Pro Leu Gly Pro Val Pro Leu Xaa Lys Glu Gln Leu Tyr 
            420                 425                 430         


Gln Gln Ala Met Glu Glu Ala Ala Trp His His Met Pro His Pro Ser 
        435                 440                 445             


Asp Ser Glu Arg Ile Arg Gln Tyr Leu Pro Arg Asn Pro Cys Pro Xaa 
    450                 455                 460                 


Pro Pro Tyr His His Gln Met Pro Pro Pro His Ser Asp Xaa Val Glu 
465                 470                 475                 480 


Phe Tyr Gln Arg Leu Ser Xaa Glu Xaa Leu Phe Phe Ile Phe Tyr Tyr 
                485                 490                 495     


Leu Glu Pro Arg Asp Val Arg Xaa Ala Trp Val Asp Ser Glu Ala Gly 
            500                 505                 510         


Pro Leu Arg His Xaa Ser Ala Pro Leu Pro Val Ala His Trp Leu Xaa 
        515                 520                 525             


Arg Gly Pro Ser Pro Ala Leu Leu Gln Gln Pro Gln Ser Arg Pro Xaa 
    530                 535                 540                 


Pro Leu Cys Ser Ser Ala His Ser Gln Ala Ser Leu Glu Xaa Xaa Gly 
545                 550                 555                 560 


Glu Leu Ser Ser Pro Leu Pro Xaa Pro Leu Leu 
                565                 570     


<210> 6556
<211> 288
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<400> 6556
Xaa Lys Glu Pro Ser Ala Ala Ala Pro Xaa Gly Ala Gly Gly Val Ala 
1               5                   10                  15      


Pro Gly Ser Gly Asn Asn Ser Gly Gly Pro Ser Leu Leu Val Pro Leu 
            20                  25                  30          


Pro Val Asn Pro Pro Ser Ser Pro Xaa Pro Ser Phe Ser Asp Ala Lys 
        35                  40                  45              


Ala Ala Gly Ala Leu Leu Asn Gly Pro Pro Gln Phe Ser Xaa Ala Pro 
    50                  55                  60                  


Glu Ile Lys Ala Pro Glu Pro Leu Ser Ser Leu Lys Ser Met Ala Glu 
65                  70                  75                  80  


Arg Ala Ala Ile Ser Ser Gly Ile Glu Asp Pro Val Pro Xaa Leu His 
                85                  90                  95      


Leu Xaa Glu Arg Asp Ile Ile Leu Ser Ser Xaa Ser Ala Pro Pro Ala 
            100                 105                 110         


Ser Ala Gln Pro Pro Leu Gln Leu Ser Glu Val Asn Ile Pro Leu Ser 
        115                 120                 125             


Leu Gly Val Cys Pro Leu Gly Pro Val Pro Leu Xaa Lys Glu Gln Leu 
    130                 135                 140                 


Tyr Gln Gln Ala Met Glu Glu Ala Ala Trp His His Met Pro His Pro 
145                 150                 155                 160 


Ser Asp Ser Glu Arg Ile Arg Gln Tyr Leu Pro Arg Asn Pro Cys Pro 
                165                 170                 175     


Xaa Pro Pro Tyr His His Gln Met Pro Pro Pro His Ser Asp Xaa Val 
            180                 185                 190         


Glu Phe Tyr Gln Arg Leu Ser Xaa Glu Xaa Leu Phe Phe Ile Phe Tyr 
        195                 200                 205             


Tyr Leu Glu Gly Xaa Lys Ala Gln Tyr Leu Ala Ala Lys Ala Leu Lys 
    210                 215                 220                 


Lys Gln Ser Trp Arg Phe His Xaa Lys Tyr Met Met Trp Phe Gln Arg 
225                 230                 235                 240 


His Glu Glu Pro Lys Xaa Ile Xaa Asp Glu Phe Glu Gln Leu Ala Gln 
                245                 250                 255     


Ser Leu Ser Leu Xaa Lys Tyr Ser Ser Leu Trp Leu Ser Ala Gln Pro 
            260                 265                 270         


Gly Xaa Pro Pro Ser His Pro Pro Leu Gly Gln Leu Leu Gly Leu Leu 
        275                 280                 285             


<210> 6557
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<400> 6557
Xaa Leu Ile Glu Xaa Gln Met Glu Arg Phe Lys Val Val Glu Arg Glu 
1               5                   10                  15      


Xaa Lys Xaa Lys Ala Tyr Ser Lys Glu Gly Leu Gly Leu Ala Gln Lys 
            20                  25                  30          


Val Asp Pro Ala Gln Lys Glu Lys Glu Glu Val Gly Gln Trp Leu Xaa 
        35                  40                  45              


Asn Xaa Ile Asp Xaa Leu Asn Met Gln Val Asp Gln Phe Glu Ser Glu 
    50                  55                  60                  


Val Glu Ser Leu Ser Val Gln Xaa Arg Lys Lys Lys Gly Asp Lys Asp 
65                  70                  75                  80  


Glu Gly Pro Ser Arg Cys Ser Ala Ala Pro Glu Pro Gly Pro Gly Leu 
                85                  90                  95      


Ala Ser Arg Ser Arg Xaa Gly Leu Arg Ala 
            100                 105     


<210> 6558
<211> 375
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<400> 6558
Xaa Arg Lys Leu Ile Glu Xaa Gln Met Glu Arg Phe Lys Val Val Glu 
1               5                   10                  15      


Arg Glu Xaa Lys Xaa Lys Ala Tyr Ser Lys Glu Gly Leu Gly Leu Ala 
            20                  25                  30          


Gln Lys Val Asp Pro Ala Gln Lys Glu Lys Glu Glu Val Gly Gln Trp 
        35                  40                  45              


Leu Xaa Asn Xaa Ile Asp Xaa Leu Asn Met Gln Val Asp Gln Phe Glu 
    50                  55                  60                  


Ser Glu Val Glu Ser Leu Ser Val Gln Xaa Arg Lys Lys Lys Gly Asp 
65                  70                  75                  80  


Lys Asp Gln Lys Gln Asp Arg Ile Glu Gly Leu Lys Arg His Ile Glu 
                85                  90                  95      


Lys His Arg Tyr His Val Arg Met Leu Glu Xaa Ile Leu Arg Met Leu 
            100                 105                 110         


Asp Asn Asp Ser Ile Leu Val Asp Ala Ile Arg Lys Ile Lys Asp Asp 
        115                 120                 125             


Val Glu Tyr Tyr Val Asp Ser Ser Gln Asp Pro Asp Phe Glu Glu Asn 
    130                 135                 140                 


Glu Phe Leu Tyr Asp Asp Leu Asp Leu Glu Asp Ile Pro Gln Ala Leu 
145                 150                 155                 160 


Val Ala Xaa Ser Pro Pro Ser His Ser His Met Glu Asp Glu Ile Phe 
                165                 170                 175     


Asn Gln Ser Ser Ser Xaa Pro Xaa Ser Xaa Xaa Ser Ser Ser Pro Ile 
            180                 185                 190         


Pro Pro Ser Pro Ala Asn Cys Xaa Xaa Glu Asn Ser Glu Asp Asp Lys 
        195                 200                 205             


Lys Arg Gly Arg Ser Xaa Asp Ser Glu Val Ser Gln Ser Pro Ala Lys 
    210                 215                 220                 


Asn Gly Ser Lys Pro Val His Ser Asn Gln His Pro Gln Ser Pro Ala 
225                 230                 235                 240 


Val Pro Pro Xaa Tyr Pro Ser Gly Pro Pro Pro Ala Ala Ser Ala Leu 
                245                 250                 255     


Ser Xaa Xaa Pro Gly Asn Asn Gly Val Pro Ala Pro Ala Ala Pro Pro 
            260                 265                 270         


Ser Ala Leu Gly Pro Lys Ala Ser Pro Ala Pro Ser His Asn Ser Gly 
        275                 280                 285             


Xaa Pro Ala Pro Tyr Ala Gln Ala Val Ala Pro Pro Ala Pro Ser Gly 
    290                 295                 300                 


Pro Ser Xaa Xaa Gln Pro Arg Pro Pro Ser Val Gln Pro Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ser Ser Ser Asn Ser 
                325                 330                 335     


Ser Ala Gly Gly Gly Ala Gly Lys Gln Asn Gly Ala Xaa Ser Tyr Ser 
            340                 345                 350         


Ser Val Val Ala Asp Ser Pro Ala Glu Val Ala Leu Ser Ser Ser Gly 
        355                 360                 365             


Gly Asn Asn Ala Ser Ser Gln 
    370                 375 


<210> 6559
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<400> 6559
Met Ala Phe Pro Arg Asn Ser Ile Met His Leu Asn His Xaa Ala Asn 
1               5                   10                  15      


Pro Xaa Ser Asn Ser Asn Phe Leu Asp Leu Asn Leu Pro Pro Gln His 
            20                  25                  30          


Asn Xaa Gly Leu Gly Gly Ile Pro Val Ala Gly Ile Pro Ala Ser Ser 
        35                  40                  45              


Gly Asn Ser Leu Asp Ser Leu Gln Asp Asp Asn Pro Pro His Trp Leu 
    50                  55                  60                  


Lys Ser Leu Gln Ala Leu Xaa Glu Met Asp Gly Pro Ala Leu Leu His 
65                  70                  75                  80  


His Arg Pro Xaa Xaa Ala Pro Leu Gln His Xaa Asp Pro Ala Ala Gln 
                85                  90                  95      


Ser Gln Leu Glu Ser Leu Pro Ser Ser Phe Lys Pro Phe Gln Leu Pro 
            100                 105                 110         


Leu Pro Xaa Pro Arg Leu Ser Asp Ser Leu Gln Xaa Pro Gln Gln Asn 
        115                 120                 125             


Pro His Arg Phe Xaa Xaa Glu Phe Asn Xaa Gly Pro Pro Leu Gly Lys 
    130                 135                 140                 


Glu Glu Gln Pro Leu Glu Asn Ala Gly Phe Val Pro Leu Cys Phe Leu 
145                 150                 155                 160 


Pro Leu Ser Pro Pro Pro Xaa Ala Pro Phe Ser Ser Leu Met Phe 
                165                 170                 175 


<210> 6560
<211> 433
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<400> 6560
Met Ser Arg Ser Pro Asp Ala Lys Glu Asp Pro Val Glu Cys Pro Leu 
1               5                   10                  15      


Cys Met Glu Pro Leu Glu Ile Asp Asp Ile Asn Phe Phe Pro Cys Xaa 
            20                  25                  30          


Cys Gly Tyr Gln Ile Cys Arg Phe Cys Trp His Arg Ile Arg Xaa Asp 
        35                  40                  45              


Glu Asn Gly Leu Cys Pro Ala Cys Arg Lys Pro Tyr Pro Glu Asp Pro 
    50                  55                  60                  


Ala Val Tyr Lys Pro Leu Ser Gln Glu Glu Leu Gln Arg Ile Lys Asn 
65                  70                  75                  80  


Glu Lys Lys Gln Lys Gln Asn Glu Arg Lys Gln Lys Ile Ser Glu Asn 
                85                  90                  95      


Arg Lys His Leu Ala Ser Val Arg Val Val Gln Lys Asn Leu Val Phe 
            100                 105                 110         


Val Val Gly Leu Ser Gln Arg Leu Ala Asp Pro Glu Val Leu Lys Arg 
        115                 120                 125             


Pro Glu Tyr Phe Gly Lys Phe Gly Lys Ile His Lys Val Val Ile Asn 
    130                 135                 140                 


Asn Ser Xaa Ser Tyr Ala Gly Ser Gln Gly Pro Ser Ala Ser Ala Tyr 
145                 150                 155                 160 


Val Xaa Tyr Ile Arg Ser Glu Asp Ala Leu Arg Ala Ile Gln Cys Val 
                165                 170                 175     


Asn Asn Val Val Val Asp Gly Arg Xaa Leu Lys Ala Ser Leu Gly Xaa 
            180                 185                 190         


Xaa Lys Tyr Cys Ser Tyr Phe Leu Lys Asn Met Gln Cys Pro Lys Pro 
        195                 200                 205             


Asp Cys Met Tyr Leu His Glu Leu Gly Asp Glu Ala Ala Ser Phe Xaa 
    210                 215                 220                 


Lys Glu Glu Met Gln Ala Gly Lys His Gln Glu Tyr Glu Gln Lys Leu 
225                 230                 235                 240 


Leu Gln Glu Leu Tyr Lys Leu Asn Pro Asn Phe Leu Gln Leu Ser Xaa 
                245                 250                 255     


Gly Ser Val Asp Lys Asn Lys Asn Lys Val Xaa Pro Leu Gln Arg Tyr 
            260                 265                 270         


Asp Xaa Pro Ile Asp Lys Pro Ser Asp Ser Leu Ser Ile Gly Asn Gly 
        275                 280                 285             


Asp Asn Ser Gln Gln Ile Ser Asn Ser Asp Xaa Pro Ser Pro Pro Pro 
    290                 295                 300                 


Gly Leu Ser Lys Ser Asn Pro Val Ile Pro Ile Ser Ser Ser Asn His 
305                 310                 315                 320 


Ser Ala Arg Ser Pro Phe Glu Gly Ala Val Xaa Glu Ser Gln Ser Leu 
                325                 330                 335     


Phe Ser Asp Asn Phe Arg His Pro Asn Pro Ile Pro Ser Gly Leu Pro 
            340                 345                 350         


Pro Phe Pro Ser Ser Pro Gln Xaa Ser Ser Asp Trp Pro Xaa Ala Pro 
        355                 360                 365             


Glu Pro Gln Ser Leu Phe Xaa Ser Glu Xaa Ile Pro Val Ser Ser Ser 
    370                 375                 380                 


Xaa Asp Trp Gln Ala Ala Phe Gly Phe Gly Ser Ser Lys Gln Pro Glu 
385                 390                 395                 400 


Asp Asp Leu Gly Phe Asp Pro Phe Asp Val Xaa Arg Lys Ala Leu Ala 
                405                 410                 415     


Asp Leu Xaa Glu Pro Ile Glu Arg Lys Arg Leu Ala Val Leu Lys Arg 
            420                 425                 430         


Arg 
    


<210> 6561
<211> 572
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(570)
<223> Selenocysteine

<400> 6561
Met Ser Arg Ser Pro Asp Ala Lys Glu Asp Pro Val Glu Cys Pro Leu 
1               5                   10                  15      


Cys Met Glu Pro Leu Glu Ile Asp Asp Ile Asn Phe Phe Pro Cys Xaa 
            20                  25                  30          


Cys Gly Tyr Gln Ile Cys Arg Phe Cys Trp His Arg Ile Arg Xaa Asp 
        35                  40                  45              


Glu Asn Gly Leu Cys Pro Ala Cys Arg Lys Pro Tyr Pro Glu Asp Pro 
    50                  55                  60                  


Ala Val Tyr Lys Pro Leu Ser Gln Glu Glu Leu Gln Arg Ile Lys Asn 
65                  70                  75                  80  


Glu Lys Lys Gln Lys Gln Asn Glu Arg Lys Gln Lys Ile Ser Glu Asn 
                85                  90                  95      


Arg Lys His Leu Ala Ser Val Arg Val Val Gln Lys Asn Leu Val Phe 
            100                 105                 110         


Val Val Gly Leu Ser Gln Arg Leu Ala Asp Pro Glu Val Leu Lys Arg 
        115                 120                 125             


Pro Glu Tyr Phe Gly Lys Phe Gly Lys Ile His Lys Val Val Ile Asn 
    130                 135                 140                 


Asn Ser Xaa Ser Tyr Ala Gly Ser Gln Gly Pro Ser Ala Ser Ala Tyr 
145                 150                 155                 160 


Val Xaa Tyr Ile Arg Ser Glu Asp Ala Leu Arg Ala Ile Gln Cys Val 
                165                 170                 175     


Asn Asn Val Val Val Asp Gly Arg Xaa Leu Lys Ala Ser Leu Gly Xaa 
            180                 185                 190         


Xaa Lys Tyr Cys Ser Tyr Phe Leu Lys Asn Met Gln Cys Pro Lys Pro 
        195                 200                 205             


Asp Cys Met Tyr Leu His Glu Leu Gly Asp Glu Ala Ala Ser Phe Xaa 
    210                 215                 220                 


Lys Glu Glu Met Gln Ala Gly Lys His Gln Glu Tyr Glu Gln Lys Leu 
225                 230                 235                 240 


Leu Gln Glu Leu Tyr Lys Leu Asn Pro Asn Phe Leu Gln Leu Ser Xaa 
                245                 250                 255     


Gly Ser Val Asp Lys Asn Lys Asn Lys Val Xaa Pro Leu Gln Ser Pro 
            260                 265                 270         


Ile Asp Lys Pro Ser Asp Ser Leu Ser Ile Gly Asn Gly Asp Asn Ser 
        275                 280                 285             


Gln Gln Ile Ser Asn Ser Asp Xaa Pro Ser Pro Pro Pro Gly Leu Ser 
    290                 295                 300                 


Lys Ser Asn Pro Val Ile Pro Ile Ser Ser Ser Asn His Ser Ala Arg 
305                 310                 315                 320 


Ser Pro Phe Glu Gly Ala Val Xaa Glu Ser Gln Ser Leu Phe Ser Asp 
                325                 330                 335     


Asn Phe Arg His Pro Asn Pro Ile Pro Ser Gly Leu Pro Pro Phe Pro 
            340                 345                 350         


Ser Ser Pro Gln Xaa Ser Ser Asp Trp Pro Xaa Ala Pro Glu Pro Gln 
        355                 360                 365             


Ser Leu Phe Xaa Ser Glu Xaa Ile Pro Val Ser Ser Ser Xaa Asp Trp 
    370                 375                 380                 


Gln Ala Ala Phe Gly Phe Gly Ser Ser Lys Gln Pro Glu Asp Asp Leu 
385                 390                 395                 400 


Gly Phe Asp Pro Phe Asp Val Xaa Arg Lys Ala Leu Ala Asp Leu Ile 
                405                 410                 415     


Glu Lys Glu Leu Ser Val Gln Asp Gln Pro Ser Leu Ser Pro Xaa Ser 
            420                 425                 430         


Leu Gln Asn Ser Ser Ser His Xaa Xaa Xaa Ala Lys Gly Pro Gly Ser 
        435                 440                 445             


Gly Phe Leu His Pro Ala Ala Ala Xaa Asn Ala Asn Ser Leu Asn Ser 
    450                 455                 460                 


Xaa Phe Ser Val Leu Pro Gln Arg Phe Pro Gln Phe Gln Gln His Arg 
465                 470                 475                 480 


Ala Val Tyr Asn Ser Phe Ser Phe Pro Gly Gln Ala Ala Arg Tyr Pro 
                485                 490                 495     


Trp Met Ala Phe Pro Arg Asn Ser Ile Met His Leu Asn His Xaa Ala 
            500                 505                 510         


Asn Pro Xaa Ser Asn Ser Asn Phe Leu Asp Leu Asn Leu Pro Pro Gln 
        515                 520                 525             


His Asn Xaa Gly Leu Gly Gly Ile Pro Val Ala Gly Glu Glu Glu Val 
    530                 535                 540                 


Lys Val Ser Xaa Met Pro Leu Ser Xaa Ser Ser His Ser Leu Gln Gln 
545                 550                 555                 560 


Gly Gln Gln Pro Xaa Ser Leu His Xaa Xaa Val Ala 
                565                 570         


<210> 6562
<211> 575
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(573)
<223> Selenocysteine

<400> 6562
Met Ser Arg Ser Pro Asp Ala Lys Glu Asp Pro Val Glu Cys Pro Leu 
1               5                   10                  15      


Cys Met Glu Pro Leu Glu Ile Asp Asp Ile Asn Phe Phe Pro Cys Xaa 
            20                  25                  30          


Cys Gly Tyr Gln Ile Cys Arg Phe Cys Trp His Arg Ile Arg Xaa Asp 
        35                  40                  45              


Glu Asn Gly Leu Cys Pro Ala Cys Arg Lys Pro Tyr Pro Glu Asp Pro 
    50                  55                  60                  


Ala Val Tyr Lys Pro Leu Ser Gln Glu Glu Leu Gln Arg Ile Lys Asn 
65                  70                  75                  80  


Glu Lys Lys Gln Lys Gln Asn Glu Arg Lys Gln Lys Ile Ser Glu Asn 
                85                  90                  95      


Arg Lys His Leu Ala Ser Val Arg Val Val Gln Lys Asn Leu Val Phe 
            100                 105                 110         


Val Val Gly Leu Ser Gln Arg Leu Ala Asp Pro Glu Val Leu Lys Arg 
        115                 120                 125             


Pro Glu Tyr Phe Gly Lys Phe Gly Lys Ile His Lys Val Val Ile Asn 
    130                 135                 140                 


Asn Ser Xaa Ser Tyr Ala Gly Ser Gln Gly Pro Ser Ala Ser Ala Tyr 
145                 150                 155                 160 


Val Xaa Tyr Ile Arg Ser Glu Asp Ala Leu Arg Ala Ile Gln Cys Val 
                165                 170                 175     


Asn Asn Val Val Val Asp Gly Arg Xaa Leu Lys Ala Ser Leu Gly Xaa 
            180                 185                 190         


Xaa Lys Tyr Cys Ser Tyr Phe Leu Lys Asn Met Gln Cys Pro Lys Pro 
        195                 200                 205             


Asp Cys Met Tyr Leu His Glu Leu Gly Asp Glu Ala Ala Ser Phe Xaa 
    210                 215                 220                 


Lys Glu Glu Met Gln Ala Gly Lys His Gln Glu Tyr Glu Gln Lys Leu 
225                 230                 235                 240 


Leu Gln Glu Leu Tyr Lys Leu Asn Pro Asn Phe Leu Gln Leu Ser Xaa 
                245                 250                 255     


Gly Ser Val Asp Lys Asn Lys Asn Lys Val Xaa Pro Leu Gln Arg Tyr 
            260                 265                 270         


Asp Xaa Pro Ile Asp Lys Pro Ser Asp Ser Leu Ser Ile Gly Asn Gly 
        275                 280                 285             


Asp Asn Ser Gln Gln Ile Ser Asn Ser Asp Xaa Pro Ser Pro Pro Pro 
    290                 295                 300                 


Gly Leu Ser Lys Ser Asn Pro Val Ile Pro Ile Ser Ser Ser Asn His 
305                 310                 315                 320 


Ser Ala Arg Ser Pro Phe Glu Gly Ala Val Xaa Glu Ser Gln Ser Leu 
                325                 330                 335     


Phe Ser Asp Asn Phe Arg His Pro Asn Pro Ile Pro Ser Gly Leu Pro 
            340                 345                 350         


Pro Phe Pro Ser Ser Pro Gln Xaa Ser Ser Asp Trp Pro Xaa Ala Pro 
        355                 360                 365             


Glu Pro Gln Ser Leu Phe Xaa Ser Glu Xaa Ile Pro Val Ser Ser Ser 
    370                 375                 380                 


Xaa Asp Trp Gln Ala Ala Phe Gly Phe Gly Ser Ser Lys Gln Pro Glu 
385                 390                 395                 400 


Asp Asp Leu Gly Phe Asp Pro Phe Asp Val Xaa Arg Lys Ala Leu Ala 
                405                 410                 415     


Asp Leu Ile Glu Lys Glu Leu Ser Val Gln Asp Gln Pro Ser Leu Ser 
            420                 425                 430         


Pro Xaa Ser Leu Gln Asn Ser Ser Ser His Xaa Xaa Xaa Ala Lys Gly 
        435                 440                 445             


Pro Gly Ser Gly Phe Leu His Pro Ala Ala Ala Xaa Asn Ala Asn Ser 
    450                 455                 460                 


Leu Asn Ser Xaa Phe Ser Val Leu Pro Gln Arg Phe Pro Gln Phe Gln 
465                 470                 475                 480 


Gln His Arg Ala Val Tyr Asn Ser Phe Ser Phe Pro Gly Gln Ala Ala 
                485                 490                 495     


Arg Tyr Pro Trp Met Ala Phe Pro Arg Asn Ser Ile Met His Leu Asn 
            500                 505                 510         


His Xaa Ala Asn Pro Xaa Ser Asn Ser Asn Phe Leu Asp Leu Asn Leu 
        515                 520                 525             


Pro Pro Gln His Asn Xaa Gly Leu Gly Gly Ile Pro Val Ala Gly Glu 
    530                 535                 540                 


Glu Glu Val Lys Val Ser Xaa Met Pro Leu Ser Xaa Ser Ser His Ser 
545                 550                 555                 560 


Leu Gln Gln Gly Gln Gln Pro Xaa Ser Leu His Xaa Xaa Val Ala 
                565                 570                 575 


<210> 6563
<211> 639
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<400> 6563
Met Ser Arg Ser Pro Asp Ala Lys Glu Asp Pro Val Glu Cys Pro Leu 
1               5                   10                  15      


Cys Met Glu Pro Leu Glu Ile Asp Asp Ile Asn Phe Phe Pro Cys Xaa 
            20                  25                  30          


Cys Gly Tyr Gln Ile Cys Arg Phe Cys Trp His Arg Ile Arg Xaa Asp 
        35                  40                  45              


Glu Asn Gly Leu Cys Pro Ala Cys Arg Lys Pro Tyr Pro Glu Asp Pro 
    50                  55                  60                  


Ala Val Tyr Lys Pro Leu Ser Gln Glu Glu Leu Gln Arg Ile Lys Asn 
65                  70                  75                  80  


Glu Lys Lys Gln Lys Gln Asn Glu Arg Lys Gln Lys Ile Ser Glu Asn 
                85                  90                  95      


Arg Lys His Leu Ala Ser Val Arg Val Val Gln Lys Asn Leu Val Phe 
            100                 105                 110         


Val Val Gly Leu Ser Gln Arg Leu Ala Asp Pro Glu Val Leu Lys Arg 
        115                 120                 125             


Pro Glu Tyr Phe Gly Lys Phe Gly Lys Ile His Lys Val Val Ile Asn 
    130                 135                 140                 


Asn Ser Xaa Ser Tyr Ala Gly Ser Gln Gly Pro Ser Ala Ser Ala Tyr 
145                 150                 155                 160 


Val Xaa Tyr Ile Arg Ser Glu Asp Ala Leu Arg Ala Ile Gln Cys Val 
                165                 170                 175     


Asn Asn Val Val Val Asp Gly Arg Xaa Leu Lys Ala Ser Leu Gly Xaa 
            180                 185                 190         


Xaa Lys Tyr Cys Ser Tyr Phe Leu Lys Asn Met Gln Cys Pro Lys Pro 
        195                 200                 205             


Asp Cys Met Tyr Leu His Glu Leu Gly Asp Glu Ala Ala Ser Phe Xaa 
    210                 215                 220                 


Lys Glu Glu Met Gln Ala Gly Lys His Gln Glu Tyr Glu Gln Lys Leu 
225                 230                 235                 240 


Leu Gln Glu Leu Tyr Lys Leu Asn Pro Asn Phe Leu Gln Leu Ser Xaa 
                245                 250                 255     


Gly Ser Val Asp Lys Asn Lys Asn Lys Val Xaa Pro Leu Gln Ser Pro 
            260                 265                 270         


Ile Asp Lys Pro Ser Asp Ser Leu Ser Ile Gly Asn Gly Asp Asn Ser 
        275                 280                 285             


Gln Gln Ile Ser Asn Ser Asp Xaa Pro Ser Pro Pro Pro Gly Leu Ser 
    290                 295                 300                 


Lys Ser Asn Pro Val Ile Pro Ile Ser Ser Ser Asn His Ser Ala Arg 
305                 310                 315                 320 


Ser Pro Phe Glu Gly Ala Val Xaa Glu Ser Gln Ser Leu Phe Ser Asp 
                325                 330                 335     


Asn Phe Arg His Pro Asn Pro Ile Pro Ser Gly Leu Pro Pro Phe Pro 
            340                 345                 350         


Ser Ser Pro Gln Xaa Ser Ser Asp Trp Pro Xaa Ala Pro Glu Pro Gln 
        355                 360                 365             


Ser Leu Phe Xaa Ser Glu Xaa Ile Pro Val Ser Ser Ser Xaa Asp Trp 
    370                 375                 380                 


Gln Ala Ala Phe Gly Phe Gly Ser Ser Lys Gln Pro Glu Asp Asp Leu 
385                 390                 395                 400 


Gly Phe Asp Pro Phe Asp Val Xaa Arg Lys Ala Leu Ala Asp Leu Ile 
                405                 410                 415     


Glu Lys Glu Leu Ser Val Gln Asp Gln Pro Ser Leu Ser Pro Xaa Ser 
            420                 425                 430         


Leu Gln Asn Ser Ser Ser His Xaa Xaa Xaa Ala Lys Gly Pro Gly Ser 
        435                 440                 445             


Gly Phe Leu His Pro Ala Ala Ala Xaa Asn Ala Asn Ser Leu Asn Ser 
    450                 455                 460                 


Xaa Phe Ser Val Leu Pro Gln Arg Phe Pro Gln Phe Gln Gln His Arg 
465                 470                 475                 480 


Ala Val Tyr Asn Ser Phe Ser Phe Pro Gly Gln Ala Ala Arg Tyr Pro 
                485                 490                 495     


Trp Met Ala Phe Pro Arg Asn Ser Ile Met His Leu Asn His Xaa Ala 
            500                 505                 510         


Asn Pro Xaa Ser Asn Ser Asn Phe Leu Asp Leu Asn Leu Pro Pro Gln 
        515                 520                 525             


His Asn Xaa Gly Leu Gly Gly Ile Pro Val Ala Gly Ile Pro Ala Ser 
    530                 535                 540                 


Ser Gly Asn Ser Leu Asp Ser Leu Gln Asp Asp Asn Pro Pro His Trp 
545                 550                 555                 560 


Leu Lys Ser Leu Gln Ala Leu Xaa Glu Met Asp Gly Pro Ser Ala Ala 
                565                 570                 575     


Pro Ser Gln Xaa His His Ser Ala Pro Phe Ser Xaa Gln Ile Pro Leu 
            580                 585                 590         


His Arg Ala Ser Trp Asn Pro Tyr Pro Pro Pro Ser Asn Pro Ser Ser 
        595                 600                 605             


Phe His Ser Pro Pro Pro Gly Phe Gln Xaa Ala Phe Arg Pro Pro Ser 
    610                 615                 620                 


Lys Xaa Pro Xaa Asp Leu Leu Gln Ser Ser Xaa Leu Asp Arg His 
625                 630                 635                 


<210> 6564
<211> 642
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<400> 6564
Met Ser Arg Ser Pro Asp Ala Lys Glu Asp Pro Val Glu Cys Pro Leu 
1               5                   10                  15      


Cys Met Glu Pro Leu Glu Ile Asp Asp Ile Asn Phe Phe Pro Cys Xaa 
            20                  25                  30          


Cys Gly Tyr Gln Ile Cys Arg Phe Cys Trp His Arg Ile Arg Xaa Asp 
        35                  40                  45              


Glu Asn Gly Leu Cys Pro Ala Cys Arg Lys Pro Tyr Pro Glu Asp Pro 
    50                  55                  60                  


Ala Val Tyr Lys Pro Leu Ser Gln Glu Glu Leu Gln Arg Ile Lys Asn 
65                  70                  75                  80  


Glu Lys Lys Gln Lys Gln Asn Glu Arg Lys Gln Lys Ile Ser Glu Asn 
                85                  90                  95      


Arg Lys His Leu Ala Ser Val Arg Val Val Gln Lys Asn Leu Val Phe 
            100                 105                 110         


Val Val Gly Leu Ser Gln Arg Leu Ala Asp Pro Glu Val Leu Lys Arg 
        115                 120                 125             


Pro Glu Tyr Phe Gly Lys Phe Gly Lys Ile His Lys Val Val Ile Asn 
    130                 135                 140                 


Asn Ser Xaa Ser Tyr Ala Gly Ser Gln Gly Pro Ser Ala Ser Ala Tyr 
145                 150                 155                 160 


Val Xaa Tyr Ile Arg Ser Glu Asp Ala Leu Arg Ala Ile Gln Cys Val 
                165                 170                 175     


Asn Asn Val Val Val Asp Gly Arg Xaa Leu Lys Ala Ser Leu Gly Xaa 
            180                 185                 190         


Xaa Lys Tyr Cys Ser Tyr Phe Leu Lys Asn Met Gln Cys Pro Lys Pro 
        195                 200                 205             


Asp Cys Met Tyr Leu His Glu Leu Gly Asp Glu Ala Ala Ser Phe Xaa 
    210                 215                 220                 


Lys Glu Glu Met Gln Ala Gly Lys His Gln Glu Tyr Glu Gln Lys Leu 
225                 230                 235                 240 


Leu Gln Glu Leu Tyr Lys Leu Asn Pro Asn Phe Leu Gln Leu Ser Xaa 
                245                 250                 255     


Gly Ser Val Asp Lys Asn Lys Asn Lys Val Xaa Pro Leu Gln Arg Tyr 
            260                 265                 270         


Asp Xaa Pro Ile Asp Lys Pro Ser Asp Ser Leu Ser Ile Gly Asn Gly 
        275                 280                 285             


Asp Asn Ser Gln Gln Ile Ser Asn Ser Asp Xaa Pro Ser Pro Pro Pro 
    290                 295                 300                 


Gly Leu Ser Lys Ser Asn Pro Val Ile Pro Ile Ser Ser Ser Asn His 
305                 310                 315                 320 


Ser Ala Arg Ser Pro Phe Glu Gly Ala Val Xaa Glu Ser Gln Ser Leu 
                325                 330                 335     


Phe Ser Asp Asn Phe Arg His Pro Asn Pro Ile Pro Ser Gly Leu Pro 
            340                 345                 350         


Pro Phe Pro Ser Ser Pro Gln Xaa Ser Ser Asp Trp Pro Xaa Ala Pro 
        355                 360                 365             


Glu Pro Gln Ser Leu Phe Xaa Ser Glu Xaa Ile Pro Val Ser Ser Ser 
    370                 375                 380                 


Xaa Asp Trp Gln Ala Ala Phe Gly Phe Gly Ser Ser Lys Gln Pro Glu 
385                 390                 395                 400 


Asp Asp Leu Gly Phe Asp Pro Phe Asp Val Xaa Arg Lys Ala Leu Ala 
                405                 410                 415     


Asp Leu Ile Glu Lys Glu Leu Ser Val Gln Asp Gln Pro Ser Leu Ser 
            420                 425                 430         


Pro Xaa Ser Leu Gln Asn Ser Ser Ser His Xaa Xaa Xaa Ala Lys Gly 
        435                 440                 445             


Pro Gly Ser Gly Phe Leu His Pro Ala Ala Ala Xaa Asn Ala Asn Ser 
    450                 455                 460                 


Leu Asn Ser Xaa Phe Ser Val Leu Pro Gln Arg Phe Pro Gln Phe Gln 
465                 470                 475                 480 


Gln His Arg Ala Val Tyr Asn Ser Phe Ser Phe Pro Gly Gln Ala Ala 
                485                 490                 495     


Arg Tyr Pro Trp Met Ala Phe Pro Arg Asn Ser Ile Met His Leu Asn 
            500                 505                 510         


His Xaa Ala Asn Pro Xaa Ser Asn Ser Asn Phe Leu Asp Leu Asn Leu 
        515                 520                 525             


Pro Pro Gln His Asn Xaa Gly Leu Gly Gly Ile Pro Val Ala Gly Ile 
    530                 535                 540                 


Pro Ala Ser Ser Gly Asn Ser Leu Asp Ser Leu Gln Asp Asp Asn Pro 
545                 550                 555                 560 


Pro His Trp Leu Lys Ser Leu Gln Ala Leu Xaa Glu Met Asp Gly Pro 
                565                 570                 575     


Ser Ala Ala Pro Ser Gln Xaa His His Ser Ala Pro Phe Ser Xaa Gln 
            580                 585                 590         


Ile Pro Leu His Arg Ala Ser Trp Asn Pro Tyr Pro Pro Pro Ser Asn 
        595                 600                 605             


Pro Ser Ser Phe His Ser Pro Pro Pro Gly Phe Gln Xaa Ala Phe Arg 
    610                 615                 620                 


Pro Pro Ser Lys Xaa Pro Xaa Asp Leu Leu Gln Ser Ser Xaa Leu Asp 
625                 630                 635                 640 


Arg His 
        


<210> 6565
<211> 710
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<400> 6565
Met Ser Arg Ser Pro Asp Ala Lys Glu Asp Pro Val Glu Cys Pro Leu 
1               5                   10                  15      


Cys Met Glu Pro Leu Glu Ile Asp Asp Ile Asn Phe Phe Pro Cys Xaa 
            20                  25                  30          


Cys Gly Tyr Gln Ile Cys Arg Phe Cys Trp His Arg Ile Arg Xaa Asp 
        35                  40                  45              


Glu Asn Gly Leu Cys Pro Ala Cys Arg Lys Pro Tyr Pro Glu Asp Pro 
    50                  55                  60                  


Ala Val Tyr Lys Pro Leu Ser Gln Glu Glu Leu Gln Arg Ile Lys Asn 
65                  70                  75                  80  


Glu Lys Lys Gln Lys Gln Asn Glu Arg Lys Gln Lys Ile Ser Glu Asn 
                85                  90                  95      


Arg Lys His Leu Ala Ser Val Arg Val Val Gln Lys Asn Leu Val Phe 
            100                 105                 110         


Val Val Gly Leu Ser Gln Arg Leu Ala Asp Pro Glu Val Leu Lys Arg 
        115                 120                 125             


Pro Glu Tyr Phe Gly Lys Phe Gly Lys Ile His Lys Val Val Ile Asn 
    130                 135                 140                 


Asn Ser Xaa Ser Tyr Ala Gly Ser Gln Gly Pro Ser Ala Ser Ala Tyr 
145                 150                 155                 160 


Val Xaa Tyr Ile Arg Ser Glu Asp Ala Leu Arg Ala Ile Gln Cys Val 
                165                 170                 175     


Asn Asn Val Val Val Asp Gly Arg Xaa Leu Lys Ala Ser Leu Gly Xaa 
            180                 185                 190         


Xaa Lys Tyr Cys Ser Tyr Phe Leu Lys Asn Met Gln Cys Pro Lys Pro 
        195                 200                 205             


Asp Cys Met Tyr Leu His Glu Leu Gly Asp Glu Ala Ala Ser Phe Xaa 
    210                 215                 220                 


Lys Glu Glu Met Gln Ala Gly Lys His Gln Glu Tyr Glu Gln Lys Leu 
225                 230                 235                 240 


Leu Gln Glu Leu Tyr Lys Leu Asn Pro Asn Phe Leu Gln Leu Ser Xaa 
                245                 250                 255     


Gly Ser Val Asp Lys Asn Lys Asn Lys Val Xaa Pro Leu Gln Ser Pro 
            260                 265                 270         


Ile Asp Lys Pro Ser Asp Ser Leu Ser Ile Gly Asn Gly Asp Asn Ser 
        275                 280                 285             


Gln Gln Ile Ser Asn Ser Asp Xaa Pro Ser Pro Pro Pro Gly Leu Ser 
    290                 295                 300                 


Lys Ser Asn Pro Val Ile Pro Ile Ser Ser Ser Asn His Ser Ala Arg 
305                 310                 315                 320 


Ser Pro Phe Glu Gly Ala Val Xaa Glu Ser Gln Ser Leu Phe Ser Asp 
                325                 330                 335     


Asn Phe Arg His Pro Asn Pro Ile Pro Ser Gly Leu Pro Pro Phe Pro 
            340                 345                 350         


Ser Ser Pro Gln Xaa Ser Ser Asp Trp Pro Xaa Ala Pro Glu Pro Gln 
        355                 360                 365             


Ser Leu Phe Xaa Ser Glu Xaa Ile Pro Val Ser Ser Ser Xaa Asp Trp 
    370                 375                 380                 


Gln Ala Ala Phe Gly Phe Gly Ser Ser Lys Gln Pro Glu Asp Asp Leu 
385                 390                 395                 400 


Gly Phe Asp Pro Phe Asp Val Xaa Arg Lys Ala Leu Ala Asp Leu Ile 
                405                 410                 415     


Glu Lys Glu Leu Ser Val Gln Asp Gln Pro Ser Leu Ser Pro Xaa Ser 
            420                 425                 430         


Leu Gln Asn Ser Ser Ser His Xaa Xaa Xaa Ala Lys Gly Pro Gly Ser 
        435                 440                 445             


Gly Phe Leu His Pro Ala Ala Ala Xaa Asn Ala Asn Ser Leu Asn Ser 
    450                 455                 460                 


Xaa Phe Ser Val Leu Pro Gln Arg Phe Pro Gln Phe Gln Gln His Arg 
465                 470                 475                 480 


Ala Val Tyr Asn Ser Phe Ser Phe Pro Gly Gln Ala Ala Arg Tyr Pro 
                485                 490                 495     


Trp Met Ala Phe Pro Arg Asn Ser Ile Met His Leu Asn His Xaa Ala 
            500                 505                 510         


Asn Pro Xaa Ser Asn Ser Asn Phe Leu Asp Leu Asn Leu Pro Pro Gln 
        515                 520                 525             


His Asn Xaa Gly Leu Gly Gly Ile Pro Val Ala Asp Asn Ser Ser Ser 
    530                 535                 540                 


Val Glu Ser Leu Asn Met Lys Glu Trp Gln Asp Gly Leu Arg Ala Leu 
545                 550                 555                 560 


Leu Pro Asn Ile Asn Ile Asn Phe Gly Gly Leu Pro Asn Ser Ser Ser 
                565                 570                 575     


Pro Ser Asn Ala Asn His Ser Ala Pro Xaa Ser Asn Xaa Ala Xaa Xaa 
            580                 585                 590         


Asp Ser Leu Ser Trp Asp Ser Pro Gly Ser Trp Xaa Asp Pro Ala Ile 
        595                 600                 605             


Ile Xaa Gly Ile Pro Ala Ser Ser Gly Asn Ser Leu Asp Ser Leu Gln 
    610                 615                 620                 


Asp Asp Asn Pro Pro His Trp Leu Lys Ser Leu Gln Ala Leu Xaa Glu 
625                 630                 635                 640 


Met Asp Gly Pro Ser Ala Ala Pro Ser Gln Xaa His His Ser Ala Pro 
                645                 650                 655     


Phe Ser Xaa Gln Ile Pro Leu His Arg Ala Ser Trp Asn Pro Tyr Pro 
            660                 665                 670         


Pro Pro Ser Asn Pro Ser Ser Phe His Ser Pro Pro Pro Gly Phe Gln 
        675                 680                 685             


Xaa Ala Phe Arg Pro Pro Ser Lys Xaa Pro Xaa Asp Leu Leu Gln Ser 
    690                 695                 700                 


Ser Xaa Leu Asp Arg His 
705                 710 


<210> 6566
<211> 713
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<400> 6566
Met Ser Arg Ser Pro Asp Ala Lys Glu Asp Pro Val Glu Cys Pro Leu 
1               5                   10                  15      


Cys Met Glu Pro Leu Glu Ile Asp Asp Ile Asn Phe Phe Pro Cys Xaa 
            20                  25                  30          


Cys Gly Tyr Gln Ile Cys Arg Phe Cys Trp His Arg Ile Arg Xaa Asp 
        35                  40                  45              


Glu Asn Gly Leu Cys Pro Ala Cys Arg Lys Pro Tyr Pro Glu Asp Pro 
    50                  55                  60                  


Ala Val Tyr Lys Pro Leu Ser Gln Glu Glu Leu Gln Arg Ile Lys Asn 
65                  70                  75                  80  


Glu Lys Lys Gln Lys Gln Asn Glu Arg Lys Gln Lys Ile Ser Glu Asn 
                85                  90                  95      


Arg Lys His Leu Ala Ser Val Arg Val Val Gln Lys Asn Leu Val Phe 
            100                 105                 110         


Val Val Gly Leu Ser Gln Arg Leu Ala Asp Pro Glu Val Leu Lys Arg 
        115                 120                 125             


Pro Glu Tyr Phe Gly Lys Phe Gly Lys Ile His Lys Val Val Ile Asn 
    130                 135                 140                 


Asn Ser Xaa Ser Tyr Ala Gly Ser Gln Gly Pro Ser Ala Ser Ala Tyr 
145                 150                 155                 160 


Val Xaa Tyr Ile Arg Ser Glu Asp Ala Leu Arg Ala Ile Gln Cys Val 
                165                 170                 175     


Asn Asn Val Val Val Asp Gly Arg Xaa Leu Lys Ala Ser Leu Gly Xaa 
            180                 185                 190         


Xaa Lys Tyr Cys Ser Tyr Phe Leu Lys Asn Met Gln Cys Pro Lys Pro 
        195                 200                 205             


Asp Cys Met Tyr Leu His Glu Leu Gly Asp Glu Ala Ala Ser Phe Xaa 
    210                 215                 220                 


Lys Glu Glu Met Gln Ala Gly Lys His Gln Glu Tyr Glu Gln Lys Leu 
225                 230                 235                 240 


Leu Gln Glu Leu Tyr Lys Leu Asn Pro Asn Phe Leu Gln Leu Ser Xaa 
                245                 250                 255     


Gly Ser Val Asp Lys Asn Lys Asn Lys Val Xaa Pro Leu Gln Arg Tyr 
            260                 265                 270         


Asp Xaa Pro Ile Asp Lys Pro Ser Asp Ser Leu Ser Ile Gly Asn Gly 
        275                 280                 285             


Asp Asn Ser Gln Gln Ile Ser Asn Ser Asp Xaa Pro Ser Pro Pro Pro 
    290                 295                 300                 


Gly Leu Ser Lys Ser Asn Pro Val Ile Pro Ile Ser Ser Ser Asn His 
305                 310                 315                 320 


Ser Ala Arg Ser Pro Phe Glu Gly Ala Val Xaa Glu Ser Gln Ser Leu 
                325                 330                 335     


Phe Ser Asp Asn Phe Arg His Pro Asn Pro Ile Pro Ser Gly Leu Pro 
            340                 345                 350         


Pro Phe Pro Ser Ser Pro Gln Xaa Ser Ser Asp Trp Pro Xaa Ala Pro 
        355                 360                 365             


Glu Pro Gln Ser Leu Phe Xaa Ser Glu Xaa Ile Pro Val Ser Ser Ser 
    370                 375                 380                 


Xaa Asp Trp Gln Ala Ala Phe Gly Phe Gly Ser Ser Lys Gln Pro Glu 
385                 390                 395                 400 


Asp Asp Leu Gly Phe Asp Pro Phe Asp Val Xaa Arg Lys Ala Leu Ala 
                405                 410                 415     


Asp Leu Ile Glu Lys Glu Leu Ser Val Gln Asp Gln Pro Ser Leu Ser 
            420                 425                 430         


Pro Xaa Ser Leu Gln Asn Ser Ser Ser His Xaa Xaa Xaa Ala Lys Gly 
        435                 440                 445             


Pro Gly Ser Gly Phe Leu His Pro Ala Ala Ala Xaa Asn Ala Asn Ser 
    450                 455                 460                 


Leu Asn Ser Xaa Phe Ser Val Leu Pro Gln Arg Phe Pro Gln Phe Gln 
465                 470                 475                 480 


Gln His Arg Ala Val Tyr Asn Ser Phe Ser Phe Pro Gly Gln Ala Ala 
                485                 490                 495     


Arg Tyr Pro Trp Met Ala Phe Pro Arg Asn Ser Ile Met His Leu Asn 
            500                 505                 510         


His Xaa Ala Asn Pro Xaa Ser Asn Ser Asn Phe Leu Asp Leu Asn Leu 
        515                 520                 525             


Pro Pro Gln His Asn Xaa Gly Leu Gly Gly Ile Pro Val Ala Asp Asn 
    530                 535                 540                 


Ser Ser Ser Val Glu Ser Leu Asn Met Lys Glu Trp Gln Asp Gly Leu 
545                 550                 555                 560 


Arg Ala Leu Leu Pro Asn Ile Asn Ile Asn Phe Gly Gly Leu Pro Asn 
                565                 570                 575     


Ser Ser Ser Pro Ser Asn Ala Asn His Ser Ala Pro Xaa Ser Asn Xaa 
            580                 585                 590         


Ala Xaa Xaa Asp Ser Leu Ser Trp Asp Ser Pro Gly Ser Trp Xaa Asp 
        595                 600                 605             


Pro Ala Ile Ile Xaa Gly Ile Pro Ala Ser Ser Gly Asn Ser Leu Asp 
    610                 615                 620                 


Ser Leu Gln Asp Asp Asn Pro Pro His Trp Leu Lys Ser Leu Gln Ala 
625                 630                 635                 640 


Leu Xaa Glu Met Asp Gly Pro Ser Ala Ala Pro Ser Gln Xaa His His 
                645                 650                 655     


Ser Ala Pro Phe Ser Xaa Gln Ile Pro Leu His Arg Ala Ser Trp Asn 
            660                 665                 670         


Pro Tyr Pro Pro Pro Ser Asn Pro Ser Ser Phe His Ser Pro Pro Pro 
        675                 680                 685             


Gly Phe Gln Xaa Ala Phe Arg Pro Pro Ser Lys Xaa Pro Xaa Asp Leu 
    690                 695                 700                 


Leu Gln Ser Ser Xaa Leu Asp Arg His 
705                 710             


<210> 6567
<211> 557
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<400> 6567
Met Pro Lys Glu Lys Tyr Glu Pro Pro Asp Pro Arg Arg Met Tyr Xaa 
1               5                   10                  15      


Ile Met Ser Ser Glu Glu Ala Ala Asn Gly Lys Lys Ser His Trp Ala 
            20                  25                  30          


Glu Leu Glu Ile Ser Gly Lys Val Arg Ser Leu Ser Ala Ser Leu Trp 
        35                  40                  45              


Ser Leu Xaa His Leu Xaa Ala Leu His Leu Ser Asp Asn Ser Leu Ser 
    50                  55                  60                  


Arg Ile Pro Ser Asp Ile Ala Lys Leu His Asn Leu Val Tyr Leu Asp 
65                  70                  75                  80  


Leu Ser Ser Asn Lys Ile Arg Ser Leu Pro Ala Glu Leu Gly Asn Met 
                85                  90                  95      


Val Ser Leu Arg Glu Leu His Leu Asn Asn Asn Leu Leu Arg Val Leu 
            100                 105                 110         


Pro Phe Glu Leu Gly Lys Leu Phe Gln Leu Gln Xaa Leu Gly Leu Lys 
        115                 120                 125             


Gly Asn Pro Leu Xaa Gln Asp Ile Leu Asn Leu Tyr Gln Glu Pro Asp 
    130                 135                 140                 


Gly Xaa Arg Arg Leu Leu Asn Tyr Leu Leu Asp Asn Leu Ser Gly Xaa 
145                 150                 155                 160 


Ala Lys Arg Ile Xaa Xaa Glu Gln Pro Pro Pro Arg Ser Trp Ile Met 
                165                 170                 175     


Leu Gln Glu Pro Asp Arg Xaa Arg Pro Xaa Ala Leu Phe Ser Val Met 
            180                 185                 190         


Cys Tyr Asn Val Leu Cys Asp Lys Tyr Ala Xaa Arg Gln Leu Tyr Gly 
        195                 200                 205             


Tyr Cys Pro Ser Trp Ala Leu Asn Trp Asp Tyr Arg Lys Lys Ala Ile 
    210                 215                 220                 


Ile Gln Glu Ile Leu Ser Cys Asn Ala Asp Ile Val Ser Leu Gln Glu 
225                 230                 235                 240 


Val Glu Xaa Glu Gln Tyr Tyr Ser Phe Phe Leu Val Glu Leu Lys Glu 
                245                 250                 255     


Arg Gly Tyr Asn Gly Phe Phe Ser Pro Lys Ser Arg Ala Arg Xaa Met 
            260                 265                 270         


Ser Glu Gln Glu Arg Lys His Val Asp Gly Cys Ala Ile Phe Phe Lys 
        275                 280                 285             


Xaa Glu Lys Phe Xaa Leu Val Gln Lys His Xaa Val Glu Phe Asn Gln 
    290                 295                 300                 


Leu Ala Met Ala Asn Ser Glu Gly Ser Glu Ala Met Leu Asn Arg Val 
305                 310                 315                 320 


Met Xaa Lys Asp Asn Ile Gly Val Ala Val Leu Leu Glu Leu Arg Lys 
                325                 330                 335     


Glu Ser Ile Glu Met Pro Ser Gly Lys Pro His Leu Gly Xaa Glu Lys 
            340                 345                 350         


Gln Leu Ile Leu Val Ala Asn Ala His Met His Trp Asp Pro Glu Tyr 
        355                 360                 365             


Ser Asp Val Lys Leu Val Gln Xaa Met Met Phe Leu Ser Glu Val Lys 
    370                 375                 380                 


Asn Ile Ile Asp Lys Ala Ser Arg Asn Leu Lys Ser Ser Val Leu Gly 
385                 390                 395                 400 


Glu Phe Gly Xaa Ile Pro Leu Val Leu Cys Ala Asp Leu Asn Ser Leu 
                405                 410                 415     


Pro Asp Ser Gly Val Val Glu Tyr Leu Ser Xaa Gly Gly Val Glu Xaa 
            420                 425                 430         


Asn His Lys Asp Phe Lys Glu Leu Arg Tyr Asn Glu Ser Leu Xaa Asn 
        435                 440                 445             


Phe Ser Cys His Gly Lys Asn Gly Xaa Xaa Asn Gly Arg Ile Xaa His 
    450                 455                 460                 


Gly Phe Lys Leu Gln Ser Ala Tyr Glu Ser Gly Leu Met Pro Tyr Xaa 
465                 470                 475                 480 


Asn Tyr Xaa Phe Asp Phe Lys Gly Ile Ile Asp Tyr Ile Phe Tyr Ser 
                485                 490                 495     


Lys Pro Gln Leu Asn Xaa Leu Gly Ile Leu Gly Pro Leu Asp His His 
            500                 505                 510         


Trp Leu Val Glu Asn Asn Ile Ser Gly Cys Pro His Pro Leu Ile Pro 
        515                 520                 525             


Ser Asp His Phe Ser Leu Phe Ala Gln Leu Glu Leu Leu Leu Pro Phe 
    530                 535                 540                 


Leu Pro Gln Val Asn Gly Ile His Leu Pro Gly Arg Arg 
545                 550                 555         


<210> 6568
<211> 235
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<400> 6568
Met Pro Lys Glu Lys Tyr Glu Pro Pro Asp Pro Arg Arg Met Tyr Xaa 
1               5                   10                  15      


Ile Met Ser Ser Glu Glu Ala Ala Asn Gly Lys Lys Ser His Trp Ala 
            20                  25                  30          


Glu Leu Glu Ile Ser Gly Asn Pro Leu Xaa Gln Asp Ile Leu Asn Leu 
        35                  40                  45              


Tyr Gln Glu Pro Asp Gly Xaa Arg Arg Leu Leu Asn Tyr Leu Leu Asp 
    50                  55                  60                  


Asn Leu Ser Val Xaa Xaa Glu Gln Pro Pro Pro Arg Ser Trp Ile Met 
65                  70                  75                  80  


Leu Gln Glu Pro Asp Arg Xaa Arg Pro Xaa Ala Leu Phe Ser Val Met 
                85                  90                  95      


Cys Tyr Asn Val Leu Cys Asp Lys Tyr Ala Xaa Arg Gln Leu Tyr Gly 
            100                 105                 110         


Tyr Cys Pro Ser Trp Ala Leu Asn Trp Asp Tyr Arg Lys Lys Ala Ile 
        115                 120                 125             


Ile Gln Glu Ile Leu Ser Cys Asn Ala Asp Ile Val Ser Leu Gln Glu 
    130                 135                 140                 


Val Glu Xaa Glu Gln Tyr Tyr Ser Phe Phe Leu Val Glu Leu Lys Glu 
145                 150                 155                 160 


Arg Gly Tyr Asn Gly Phe Phe Ser Pro Lys Ser Arg Ala Arg Xaa Met 
                165                 170                 175     


Ser Glu Gln Glu Arg Lys His Val Asp Gly Cys Ala Ile Phe Phe Lys 
            180                 185                 190         


Xaa Glu Lys Phe Xaa Leu Val Gln Lys His Xaa Val Glu Phe Asn Gln 
        195                 200                 205             


Leu Ala Met Ala Asn Ser Glu Gly Ser Glu Ala Met Leu Asn Arg Val 
    210                 215                 220                 


Met Xaa Lys Asp Asn Ile Gly Val Ala Val Leu 
225                 230                 235 


<210> 6569
<211> 260
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<400> 6569
Leu Lys Ser Cys His Cys Gln Val Ala Ala Ala Ser Asn Gln Glu Val 
1               5                   10                  15      


Glu Xaa Glu Gln Tyr Phe Xaa Leu Phe Leu Pro Ala Leu Lys Glu Arg 
            20                  25                  30          


Gly Tyr Asp Gly Phe Phe Ser Pro Lys Ser Arg Ala Lys Ile Met Ser 
        35                  40                  45              


Glu Gln Glu Arg Lys His Val Asp Gly Cys Ala Ile Phe Phe Lys Xaa 
    50                  55                  60                  


Glu Lys Phe Xaa Leu Val Gln Lys His Xaa Val Glu Phe Asn Gln Val 
65                  70                  75                  80  


Ala Met Ala Asn Ser Asp Gly Ser Glu Ala Met Leu Asn Arg Val Met 
                85                  90                  95      


Xaa Lys Asp Asn Ile Gly Val Ala Val Val Leu Glu Val His Lys Glu 
            100                 105                 110         


Leu Phe Gly Ala Gly Met Lys Pro Ile His Ala Ala Asp Lys Gln Leu 
        115                 120                 125             


Leu Ile Val Ala Asn Ala His Met His Trp Asp Pro Glu Tyr Ser Asp 
    130                 135                 140                 


Val Lys Leu Ile Gln Xaa Met Met Phe Val Ser Glu Val Lys Asn Ile 
145                 150                 155                 160 


Leu Glu Lys Ala Ser Ser Arg Pro Gly Ser Pro Xaa Ala Asp Pro Asn 
                165                 170                 175     


Ser Ile Pro Leu Val Leu Cys Ala Asp Leu Asn Ser Leu Pro Asp Ser 
            180                 185                 190         


Gly Val Val Glu Tyr Leu Ser Asn Gly Gly Val Ala Asp Asn His Lys 
        195                 200                 205             


Asp Phe Lys Glu Leu Arg Tyr Asn Glu Cys Leu Met Asn Phe Ser Cys 
    210                 215                 220                 


Asn Gly Lys Asn Gly Ser Ser Glu Gly Arg Ile Xaa His Gly Phe Gln 
225                 230                 235                 240 


Leu Lys Ser Ala Tyr Glu Asn Asn Leu Met Pro Tyr Xaa Asn Tyr Xaa 
                245                 250                 255     


Phe Asp Phe Lys 
            260 


<210> 6570
<211> 46
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<400> 6570
Met Arg Leu Ile Gly Met Pro Lys Glu Lys Tyr Asp Pro Pro Asp Pro 
1               5                   10                  15      


Arg Arg Ile Tyr Xaa Ile Met Ser Ala Glu Glu Val Ala Asn Gly Lys 
            20                  25                  30          


Lys Ser His Trp Ala Glu Leu Glu Ile Ser Glu Cys Gly Ala 
        35                  40                  45      


<210> 6571
<211> 163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<400> 6571
Met Arg Leu Ile Gly Met Pro Lys Glu Lys Tyr Asp Pro Pro Asp Pro 
1               5                   10                  15      


Arg Arg Ile Tyr Xaa Ile Met Ser Ala Glu Glu Val Ala Asn Gly Lys 
            20                  25                  30          


Lys Ser His Trp Ala Glu Leu Glu Ile Ser Gly Arg Val Arg Ser Leu 
        35                  40                  45              


Ser Xaa Ser Leu Trp Ser Leu Xaa His Leu Xaa Ala Leu His Leu Asn 
    50                  55                  60                  


Asp Asn Tyr Leu Ser Arg Ile Pro Pro Asp Ile Ala Lys Leu His Asn 
65                  70                  75                  80  


Leu Val Tyr Leu Asp Leu Ser Ser Asn Lys Leu Arg Ser Leu Pro Ala 
                85                  90                  95      


Glu Leu Gly Asn Met Val Ser Leu Arg Glu Leu Leu Leu Asn Asn Asn 
            100                 105                 110         


Leu Leu Arg Val Leu Pro Tyr Glu Leu Gly Arg Leu Phe Gln Leu Gln 
        115                 120                 125             


Xaa Leu Gly Leu Lys Gly Asn Pro Leu Ser Gln Asp Ile Leu Asn Leu 
    130                 135                 140                 


Tyr Gln Asp Pro Asp Gly Xaa Arg Lys Leu Leu Asn Phe Met Leu Asp 
145                 150                 155                 160 


Asn Leu Ala 
            


<210> 6572
<211> 555
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<400> 6572
Met Arg Leu Ile Gly Met Pro Lys Glu Lys Tyr Asp Pro Pro Asp Pro 
1               5                   10                  15      


Arg Arg Ile Tyr Xaa Ile Met Ser Ala Glu Glu Val Ala Asn Gly Lys 
            20                  25                  30          


Lys Ser His Trp Ala Glu Leu Glu Ile Ser Gly Arg Val Arg Ser Leu 
        35                  40                  45              


Ser Xaa Ser Leu Trp Ser Leu Xaa His Leu Xaa Ala Leu His Leu Asn 
    50                  55                  60                  


Asp Asn Tyr Leu Ser Arg Ile Pro Pro Asp Ile Ala Lys Leu His Asn 
65                  70                  75                  80  


Leu Val Tyr Leu Asp Leu Ser Ser Asn Lys Leu Arg Ser Leu Pro Ala 
                85                  90                  95      


Glu Leu Gly Asn Met Val Ser Leu Arg Glu Leu Leu Leu Asn Asn Asn 
            100                 105                 110         


Leu Leu Arg Val Leu Pro Tyr Glu Leu Gly Arg Leu Phe Gln Leu Gln 
        115                 120                 125             


Xaa Leu Gly Leu Lys Gly Asn Pro Leu Ser Gln Asp Ile Leu Asn Leu 
    130                 135                 140                 


Tyr Gln Asp Pro Asp Gly Xaa Arg Lys Leu Leu Asn Phe Met Leu Asp 
145                 150                 155                 160 


Asn Leu Ala Val His Pro Glu Gln Leu Pro Pro Arg Pro Trp Ile Xaa 
                165                 170                 175     


Leu Lys Glu Arg Asp Gln Ile Leu Pro Ser Ala Ser Phe Xaa Val Met 
            180                 185                 190         


Cys Tyr Asn Val Leu Cys Asp Lys Tyr Ala Xaa Arg Gln Leu Tyr Gly 
        195                 200                 205             


Tyr Cys Pro Ser Trp Ala Leu Asn Trp Glu Tyr Arg Lys Lys Gly Ile 
    210                 215                 220                 


Met Glu Glu Ile Val Asn Cys Asp Ala Asp Ile Ile Ser Leu Gln Glu 
225                 230                 235                 240 


Val Glu Xaa Glu Gln Tyr Phe Xaa Leu Phe Leu Pro Ala Leu Lys Glu 
                245                 250                 255     


Arg Gly Tyr Asp Gly Phe Phe Ser Pro Lys Ser Arg Ala Lys Ile Met 
            260                 265                 270         


Ser Glu Gln Glu Arg Lys His Val Asp Gly Cys Ala Ile Phe Phe Lys 
        275                 280                 285             


Xaa Glu Lys Phe Xaa Leu Val Gln Lys His Xaa Val Glu Phe Asn Gln 
    290                 295                 300                 


Val Ala Met Ala Asn Ser Asp Gly Ser Glu Ala Met Leu Asn Arg Val 
305                 310                 315                 320 


Met Xaa Lys Asp Asn Ile Gly Val Ala Val Val Leu Glu Val His Lys 
                325                 330                 335     


Glu Leu Phe Gly Ala Gly Met Lys Pro Ile His Ala Ala Asp Lys Gln 
            340                 345                 350         


Leu Leu Ile Val Ala Asn Ala His Met His Trp Asp Pro Glu Tyr Ser 
        355                 360                 365             


Asp Val Lys Leu Ile Gln Xaa Met Met Phe Val Ser Glu Val Lys Asn 
    370                 375                 380                 


Ile Leu Glu Lys Ala Ser Ser Arg Pro Gly Ser Pro Xaa Ala Asp Pro 
385                 390                 395                 400 


Asn Ser Ile Pro Leu Val Leu Cys Ala Asp Leu Asn Ser Leu Pro Asp 
                405                 410                 415     


Ser Gly Val Val Glu Tyr Leu Ser Asn Gly Gly Val Ala Asp Asn His 
            420                 425                 430         


Lys Asp Phe Lys Glu Leu Arg Tyr Asn Glu Cys Leu Met Asn Phe Ser 
        435                 440                 445             


Cys Asn Gly Lys Asn Gly Ser Ser Glu Gly Arg Ile Xaa His Gly Phe 
    450                 455                 460                 


Gln Leu Lys Ser Ala Tyr Glu Asn Asn Leu Met Pro Tyr Xaa Asn Tyr 
465                 470                 475                 480 


Xaa Phe Asp Phe Lys Gly Val Ile Asp Tyr Ile Phe Tyr Ser Lys Xaa 
                485                 490                 495     


His Met Asn Val Leu Gly Val Leu Gly Pro Leu Asp Pro Gln Trp Leu 
            500                 505                 510         


Val Glu Asn Asn Ile Xaa Gly Cys Pro His Pro His Ile Pro Ser Asp 
        515                 520                 525             


His Phe Ser Leu Leu Xaa Gln Leu Glu Leu His Pro Pro Leu Leu Pro 
    530                 535                 540                 


Leu Val Asn Gly Val His Leu Pro Asn Arg Arg 
545                 550                 555 


<210> 6573
<211> 562
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<400> 6573
Pro Gly Pro Arg Arg Ala Glu Cys Arg Leu Ile Gly Met Pro Lys Glu 
1               5                   10                  15      


Lys Tyr Asp Pro Pro Asp Pro Arg Arg Ile Tyr Xaa Ile Met Ser Ala 
            20                  25                  30          


Glu Glu Val Ala Asn Gly Lys Lys Ser His Trp Ala Glu Leu Glu Ile 
        35                  40                  45              


Ser Gly Arg Val Arg Ser Leu Ser Xaa Ser Leu Trp Ser Leu Xaa His 
    50                  55                  60                  


Leu Xaa Ala Leu His Leu Asn Asp Asn Tyr Leu Ser Arg Ile Pro Pro 
65                  70                  75                  80  


Asp Ile Ala Lys Leu His Asn Leu Val Tyr Leu Asp Leu Ser Ser Asn 
                85                  90                  95      


Lys Leu Arg Ser Leu Pro Ala Glu Leu Gly Asn Met Val Ser Leu Arg 
            100                 105                 110         


Glu Leu Leu Leu Asn Asn Asn Leu Leu Arg Val Leu Pro Tyr Glu Leu 
        115                 120                 125             


Gly Arg Leu Phe Gln Leu Gln Xaa Leu Gly Leu Lys Gly Asn Pro Leu 
    130                 135                 140                 


Ser Gln Asp Ile Leu Asn Leu Tyr Gln Asp Pro Asp Gly Xaa Arg Lys 
145                 150                 155                 160 


Leu Leu Asn Phe Met Leu Asp Asn Leu Ala Val His Pro Glu Gln Leu 
                165                 170                 175     


Pro Pro Arg Pro Trp Ile Xaa Leu Lys Glu Arg Asp Gln Ile Leu Pro 
            180                 185                 190         


Ser Ala Ser Phe Xaa Val Met Cys Tyr Asn Val Leu Cys Asp Lys Tyr 
        195                 200                 205             


Ala Xaa Arg Gln Leu Tyr Gly Tyr Cys Pro Ser Trp Ala Leu Asn Trp 
    210                 215                 220                 


Glu Tyr Arg Lys Lys Gly Ile Met Glu Glu Ile Val Asn Cys Asp Ala 
225                 230                 235                 240 


Asp Ile Ile Ser Leu Gln Glu Val Glu Xaa Glu Gln Tyr Phe Xaa Leu 
                245                 250                 255     


Phe Leu Pro Ala Leu Lys Glu Arg Gly Tyr Asp Gly Phe Phe Ser Pro 
            260                 265                 270         


Lys Ser Arg Ala Lys Ile Met Ser Glu Gln Glu Arg Lys His Val Asp 
        275                 280                 285             


Gly Cys Ala Ile Phe Phe Lys Xaa Glu Lys Phe Xaa Leu Val Gln Lys 
    290                 295                 300                 


His Xaa Val Glu Phe Asn Gln Val Ala Met Ala Asn Ser Asp Gly Ser 
305                 310                 315                 320 


Glu Ala Met Leu Asn Arg Val Met Xaa Lys Asp Asn Ile Gly Val Ala 
                325                 330                 335     


Val Val Leu Glu Val His Lys Glu Leu Phe Gly Ala Gly Met Lys Pro 
            340                 345                 350         


Ile His Ala Ala Asp Lys Gln Leu Leu Ile Val Ala Asn Ala His Met 
        355                 360                 365             


His Trp Asp Pro Glu Tyr Ser Asp Val Lys Leu Ile Gln Xaa Met Met 
    370                 375                 380                 


Phe Val Ser Glu Val Lys Asn Ile Leu Glu Lys Ala Ser Ser Arg Pro 
385                 390                 395                 400 


Gly Ser Pro Xaa Ala Asp Pro Asn Ser Ile Pro Leu Val Leu Cys Ala 
                405                 410                 415     


Asp Leu Asn Ser Leu Pro Asp Ser Gly Val Val Glu Tyr Leu Ser Asn 
            420                 425                 430         


Gly Gly Val Ala Asp Asn His Lys Asp Phe Lys Glu Leu Arg Tyr Asn 
        435                 440                 445             


Glu Cys Leu Met Asn Phe Ser Cys Asn Gly Lys Asn Gly Ser Ser Glu 
    450                 455                 460                 


Gly Arg Ile Xaa His Gly Phe Gln Leu Lys Ser Ala Tyr Glu Asn Asn 
465                 470                 475                 480 


Leu Met Pro Tyr Xaa Asn Tyr Xaa Phe Asp Phe Lys Gly Val Ile Asp 
                485                 490                 495     


Tyr Ile Phe Tyr Ser Lys Xaa His Met Asn Val Leu Gly Val Leu Gly 
            500                 505                 510         


Pro Leu Asp Pro Gln Trp Leu Val Glu Asn Asn Ile Xaa Gly Cys Pro 
        515                 520                 525             


His Pro His Ile Pro Ser Asp His Phe Ser Leu Leu Xaa Gln Leu Glu 
    530                 535                 540                 


Leu His Pro Pro Leu Leu Pro Leu Val Asn Gly Val His Leu Pro Asn 
545                 550                 555                 560 


Arg Arg 
        


<210> 6574
<211> 469
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<400> 6574
Xaa Cys Val Cys Val Ser Gly Val Ala Arg Gly Arg Asp Pro Arg Val 
1               5                   10                  15      


Ala Cys Pro Ser Arg Phe Val Ala Ala Ala Pro Glu Pro Arg Arg Leu 
            20                  25                  30          


Ile Gly Met Pro Lys Glu Lys Tyr Asp Pro Pro Asp Pro Arg Arg Ile 
        35                  40                  45              


Tyr Xaa Ile Met Ser Ala Glu Glu Val Ala Asn Gly Lys Lys Ser His 
    50                  55                  60                  


Trp Ala Glu Leu Glu Ile Ser Gly Arg Val Arg Ser Leu Ser Xaa Ser 
65                  70                  75                  80  


Leu Trp Ser Leu Xaa His Leu Xaa Ala Leu His Leu Asn Asp Asn Tyr 
                85                  90                  95      


Leu Ser Arg Ile Pro Pro Asp Ile Ala Lys Leu His Asn Leu Val Tyr 
            100                 105                 110         


Leu Asp Leu Ser Ser Asn Lys Leu Arg Ser Leu Pro Ala Glu Leu Gly 
        115                 120                 125             


Asn Met Val Ser Leu Arg Glu Leu Leu Leu Asn Asn Asn Leu Leu Arg 
    130                 135                 140                 


Val Leu Pro Tyr Glu Leu Gly Arg Leu Phe Gln Leu Gln Xaa Leu Gly 
145                 150                 155                 160 


Leu Lys Gly Asn Pro Leu Ser Gln Asp Ile Leu Asn Leu Tyr Gln Asp 
                165                 170                 175     


Pro Asp Gly Xaa Arg Lys Leu Leu Asn Phe Met Leu Asp Asn Leu Ala 
            180                 185                 190         


Val His Pro Glu Gln Leu Pro Pro Arg Pro Trp Ile Xaa Leu Lys Glu 
        195                 200                 205             


Arg Asp Gln Ile Leu Pro Ser Ala Ser Phe Xaa Val Met Cys Tyr Asn 
    210                 215                 220                 


Val Leu Cys Asp Lys Tyr Ala Xaa Arg Gln Leu Tyr Gly Tyr Cys Pro 
225                 230                 235                 240 


Ser Trp Ala Leu Asn Trp Glu Tyr Arg Lys Lys Gly Ile Met Glu Glu 
                245                 250                 255     


Ile Val Asn Cys Asp Ala Asp Ile Ile Ser Leu Gln Glu Val Glu Xaa 
            260                 265                 270         


Glu Gln Tyr Phe Xaa Leu Phe Leu Pro Ala Leu Lys Glu Arg Gly Tyr 
        275                 280                 285             


Asp Gly Phe Phe Ser Pro Lys Ser Arg Ala Lys Ile Met Ser Glu Gln 
    290                 295                 300                 


Glu Arg Lys His Val Asp Gly Cys Ala Ile Phe Phe Lys Xaa Glu Lys 
305                 310                 315                 320 


Phe Xaa Leu Val Gln Lys His Xaa Val Glu Phe Asn Gln Val Ala Met 
                325                 330                 335     


Ala Asn Ser Asp Gly Ser Glu Ala Met Leu Asn Arg Val Met Xaa Lys 
            340                 345                 350         


Asp Asn Ile Gly Val Ala Val Val Leu Glu Val His Lys Glu Leu Phe 
        355                 360                 365             


Gly Ala Gly Met Lys Pro Ile His Ala Ala Asp Lys Gln Leu Leu Ile 
    370                 375                 380                 


Val Ala Asn Ala His Met His Trp Asp Pro Glu Tyr Ser Asp Val Lys 
385                 390                 395                 400 


Leu Ile Gln Xaa Met Met Phe Val Ser Glu Val Lys Asn Ile Leu Glu 
                405                 410                 415     


Lys Ala Ser Ser Arg Pro Gly Ser Pro Xaa Ala Asp Pro Asn Ser Ile 
            420                 425                 430         


Pro Leu Val Leu Cys Ala Asp Leu Asn Ser Leu Pro Asp Ser Gly Val 
        435                 440                 445             


Val Glu Tyr Leu Ser Asn Gly Gly Val Ala Asp Asn His Lys Asp Phe 
    450                 455                 460                 


Lys Glu Leu Arg Ala 
465                 


<210> 6575
<211> 41
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<400> 6575
Met Pro Ala Ala Xaa Val Asp His Ser Gln Arg Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Cys Asn Leu Asp Glu Glu Met Lys Lys Ile Arg Gln Val Ile Arg 
            20                  25                  30          


Lys Tyr Asn Tyr Val Ala Met Asp Xaa 
        35                  40      


<210> 6576
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<400> 6576
Met Pro Ala Ala Xaa Val Asp His Ser Gln Arg Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Cys Asn Leu Asp Glu Glu Met Lys Lys Ile Arg Gln Val Ile Arg 
            20                  25                  30          


Lys Tyr Asn Tyr Val Ala Met Asp Xaa Glu Phe Pro Gly Val Val Ala 
        35                  40                  45              


Arg Pro Ile Gly Glu Phe Arg Ser Asn Ala Asp Tyr Gln Tyr Gln Leu 
    50                  55                  60                  


Leu Arg Cys Asn Val Asp Leu Leu Lys Ile Ile Gln Leu Gly Leu Xaa 
65                  70                  75                  80  


Phe Met Asn Glu Gln Gly Glu Tyr Pro Pro Gly Xaa Ser Xaa Trp Gln 
                85                  90                  95      


Phe Asn Phe Lys Phe Asn Leu Xaa Glu Asp Met Tyr Ala Gln Asp Ser 
            100                 105                 110         


Ile Glu Leu Leu Xaa Xaa Ser Gly Ile Gln Phe Lys Lys His Glu Glu 
        115                 120                 125             


Glu Gly Ile Glu Xaa Gln Tyr Phe Ala Glu Leu Leu Met Xaa Ser Gly 
    130                 135                 140                 


Val Val Leu 
145         


<210> 6577
<211> 285
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<400> 6577
Met Pro Ala Ala Xaa Val Asp His Ser Gln Arg Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Cys Asn Leu Asp Glu Glu Met Lys Lys Ile Arg Gln Val Ile Arg 
            20                  25                  30          


Lys Tyr Asn Tyr Val Ala Met Asp Xaa Glu Phe Pro Gly Val Val Ala 
        35                  40                  45              


Arg Pro Ile Gly Glu Phe Arg Ser Asn Ala Asp Tyr Gln Tyr Gln Leu 
    50                  55                  60                  


Leu Arg Cys Asn Val Asp Leu Leu Lys Ile Ile Gln Leu Gly Leu Xaa 
65                  70                  75                  80  


Phe Met Asn Glu Gln Gly Glu Tyr Pro Pro Gly Xaa Ser Xaa Trp Gln 
                85                  90                  95      


Phe Asn Phe Lys Phe Asn Leu Xaa Glu Asp Met Tyr Ala Gln Asp Ser 
            100                 105                 110         


Ile Glu Leu Leu Xaa Xaa Ser Gly Ile Gln Phe Lys Lys His Glu Glu 
        115                 120                 125             


Glu Gly Ile Glu Xaa Gln Tyr Phe Ala Glu Leu Leu Met Xaa Ser Gly 
    130                 135                 140                 


Val Val Leu Cys Glu Gly Val Lys Trp Leu Ser Phe His Ser Gly Tyr 
145                 150                 155                 160 


Asp Phe Gly Tyr Leu Ile Lys Ile Leu Xaa Asn Ser Asn Leu Pro Glu 
                165                 170                 175     


Glu Glu Leu Asp Phe Phe Glu Ile Leu Arg Leu Phe Phe Pro Val Ile 
            180                 185                 190         


Tyr Asp Val Lys Tyr Leu Met Lys Ser Cys Lys Asn Leu Lys Gly Gly 
        195                 200                 205             


Leu Gln Glu Val Ala Glu Gln Leu Glu Leu Glu Arg Ile Gly Pro Gln 
    210                 215                 220                 


His Gln Ala Gly Ser Asp Ser Leu Leu Xaa Gly Met Ala Phe Phe Lys 
225                 230                 235                 240 


Met Arg Glu Met Phe Phe Glu Asp His Ile Asp Asp Ala Lys Tyr Cys 
                245                 250                 255     


Gly His Leu Tyr Gly Leu Gly Ser Gly Ser Ser Tyr Val Gln Asn Gly 
            260                 265                 270         


Xaa Gly Asn Ala Tyr Glu Glu Glu Ala Asn Lys Gln Ser 
        275                 280                 285 


<210> 6578
<211> 244
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<400> 6578
Met Pro Ala Ala Xaa Val Asp His Ser Gln Arg Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Cys Asn Leu Asp Glu Glu Met Lys Lys Ile Arg Gln Val Ile Arg 
            20                  25                  30          


Lys Tyr Asn Tyr Val Ala Met Asp Xaa Glu Phe Pro Gly Val Val Ala 
        35                  40                  45              


Arg Pro Ile Gly Glu Phe Arg Ser Asn Ala Asp Tyr Gln Tyr Gln Leu 
    50                  55                  60                  


Leu Arg Cys Asn Val Asp Leu Leu Lys Ile Ile Gln Leu Gly Leu Xaa 
65                  70                  75                  80  


Phe Met Asn Glu Gln Gly Glu Tyr Pro Pro Gly Xaa Ser Xaa Trp Gln 
                85                  90                  95      


Phe Asn Phe Lys Phe Asn Leu Xaa Glu Asp Met Tyr Ala Gln Asp Ser 
            100                 105                 110         


Ile Glu Leu Leu Xaa Xaa Ser Gly Ile Gln Phe Lys Lys His Glu Glu 
        115                 120                 125             


Glu Gly Ile Glu Xaa Gln Tyr Phe Ala Glu Leu Leu Met Xaa Ser Gly 
    130                 135                 140                 


Val Val Leu Cys Glu Gly Val Lys Trp Leu Ser Phe His Ser Gly Tyr 
145                 150                 155                 160 


Asp Phe Gly Tyr Leu Ile Lys Ile Leu Xaa Asn Ser Asn Leu Pro Glu 
                165                 170                 175     


Glu Glu Leu Asp Phe Phe Glu Ile Leu Arg Leu Phe Phe Pro Val Ile 
            180                 185                 190         


Tyr Asp Val Lys Tyr Leu Met Lys Ser Cys Lys Asn Leu Lys Gly Gly 
        195                 200                 205             


Leu Gln Glu Val Ala Glu Gln Leu Glu Leu Glu Arg Ile Gly Pro Gln 
    210                 215                 220                 


His Gln Ala Gly Ser Asp Ser Leu Leu Xaa Gly Met Ala Phe Phe Lys 
225                 230                 235                 240 


Met Arg Glu Val 
                


<210> 6579
<211> 51
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<400> 6579
Met Pro Ala Ala Xaa Val Asp His Ser Gln Arg Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Cys Asn Leu Asp Glu Glu Met Lys Lys Ile Arg Gln Val Ile Arg 
            20                  25                  30          


Lys Tyr Asn Tyr Val Ala Met Phe Phe Lys Lys Leu Gly Phe Ser Ile 
        35                  40                  45              


Gly Ile Leu 
    50      


<210> 6580
<211> 62
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<400> 6580
Met Pro Ala Ala Xaa Val Asp His Ser Gln Arg Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Cys Asn Leu Asp Glu Glu Met Lys Lys Ile Arg Gln Val Ile Arg 
            20                  25                  30          


Lys Tyr Asn Tyr Val Ala Met Gly Phe Gly Val Glu Lys Asn Leu Val 
        35                  40                  45              


Ser Glu Lys Gln Leu Glu Ser Xaa Gly Arg Phe Pro Leu Phe 
    50                  55                  60          


<210> 6581
<211> 208
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<400> 6581
Xaa Glu Glu Met Lys Lys Ile Arg Gln Val Ile Arg Lys Tyr Asn Tyr 
1               5                   10                  15      


Val Ala Met Asp Xaa Glu Phe Pro Gly Val Val Ala Arg Pro Ile Gly 
            20                  25                  30          


Glu Phe Arg Ser Asn Ala Asp Tyr Gln Tyr Gln Leu Leu Arg Cys Asn 
        35                  40                  45              


Val Asp Leu Leu Lys Ile Ile Gln Leu Gly Leu Xaa Phe Met Asn Glu 
    50                  55                  60                  


Gln Gly Glu Tyr Pro Pro Gly Xaa Ser Xaa Trp Gln Phe Asn Phe Lys 
65                  70                  75                  80  


Phe Asn Leu Xaa Glu Asp Met Tyr Ala Gln Asp Ser Ile Glu Leu Leu 
                85                  90                  95      


Xaa Xaa Ser Gly Ile Gln Phe Lys Lys His Glu Glu Glu Gly Ile Glu 
            100                 105                 110         


Xaa Gln Tyr Phe Ala Glu Leu Leu Met Xaa Ser Gly Val Val Leu Cys 
        115                 120                 125             


Glu Gly Val Lys Trp Leu Ser Phe His Ser Gly Tyr Asp Phe Gly Tyr 
    130                 135                 140                 


Leu Ile Lys Ile Leu Xaa Asn Ser Asn Leu Pro Glu Glu Glu Leu Asp 
145                 150                 155                 160 


Phe Phe Glu Ile Leu Arg Leu Phe Phe Pro Val Ile Tyr Asp Val Lys 
                165                 170                 175     


Tyr Leu Met Lys Ser Cys Lys Asn Leu Lys Val Arg Leu Arg Met Ala 
            180                 185                 190         


Leu Ser Xaa Ala Ala His Cys Ser Asp Gln Val Xaa Val Met Arg Ala 
        195                 200                 205             


<210> 6582
<211> 91
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<400> 6582
Xaa Gly Tyr Asp Phe Gly Tyr Leu Ile Lys Ile Leu Xaa Asn Ser Asn 
1               5                   10                  15      


Leu Pro Glu Glu Glu Leu Asp Phe Phe Glu Ile Leu Arg Leu Phe Phe 
            20                  25                  30          


Pro Val Ile Tyr Asp Val Lys Tyr Leu Met Lys Ser Cys Lys Asn Leu 
        35                  40                  45              


Lys Met Phe Phe Glu Asp His Ile Asp Asp Ala Lys Tyr Cys Gly His 
    50                  55                  60                  


Leu Tyr Gly Leu Gly Ser Gly Ser Ser Tyr Val Gln Asn Gly Xaa Gly 
65                  70                  75                  80  


Asn Ala Tyr Glu Glu Glu Ala Asn Lys Gln Ser 
                85                  90      


<210> 6583
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<400> 6583
Met Pro Ala Ala Leu Val Glu Asn Ser Gln Val Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Ser Asn Leu Glu Glu Glu Met Arg Lys Ile Arg Glu Ile Val Leu 
            20                  25                  30          


Ser Tyr Ser Tyr Ile Ala Met Asp Xaa Glu Phe Pro Gly Val Val Val 
        35                  40                  45              


Arg Pro Ile Gly Glu Phe Arg 
    50                  55  


<210> 6584
<211> 90
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<400> 6584
Met Pro Ala Ala Leu Val Glu Asn Ser Gln Val Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Ser Asn Leu Glu Glu Glu Met Arg Lys Ile Arg Glu Ile Val Leu 
            20                  25                  30          


Ser Tyr Ser Tyr Ile Ala Met Asp Xaa Glu Phe Pro Gly Val Val Val 
        35                  40                  45              


Arg Pro Ile Gly Glu Phe Arg Ser Ser Ile Asp Tyr Gln Tyr Gln Leu 
    50                  55                  60                  


Leu Arg Cys Asn Val Asp Leu Leu Lys Ile Ile Gln Leu Gly Leu Xaa 
65                  70                  75                  80  


Phe Xaa Asn Glu Lys Gly Glu Tyr Pro Ser 
                85                  90  


<210> 6585
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<400> 6585
Met Pro Ala Ala Leu Val Glu Asn Ser Gln Val Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Ser Asn Leu Glu Glu Glu Met Arg Lys Ile Arg Glu Ile Val Leu 
            20                  25                  30          


Ser Tyr Ser Tyr Ile Ala Met Asp Xaa Glu Phe Pro Gly Val Val Val 
        35                  40                  45              


Arg Pro Ile Gly Glu Phe Arg Ser Ser Ile Asp Tyr Gln Tyr Gln Leu 
    50                  55                  60                  


Leu Arg Cys Asn Val Asp Leu Leu Lys Ile Ile Gln Leu Gly Leu Xaa 
65                  70                  75                  80  


Phe Xaa Asn Glu Lys Gly Glu Tyr Pro Ser Gly Ile Asn Xaa Trp Gln 
                85                  90                  95      


Phe Asn Phe Lys Phe Asn Leu Xaa Glu Asp Met Tyr Ser Gln Asp Ser 
            100                 105                 110         


Ile Asp Leu Leu Ala Asn 
        115             


<210> 6586
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<400> 6586
Met Pro Ala Ala Leu Val Glu Asn Ser Gln Val Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Ser Asn Leu Glu Glu Glu Met Arg Lys Ile Arg Glu Ile Val Leu 
            20                  25                  30          


Ser Tyr Ser Tyr Ile Ala Met Asp Xaa Glu Phe Pro Gly Val Val Val 
        35                  40                  45              


Arg Pro Ile Gly Glu Phe Arg Ser Ser Ile Asp Tyr Gln Tyr Gln Leu 
    50                  55                  60                  


Leu Arg Cys Asn Val Asp Leu Leu Lys Ile Ile Gln Leu Gly Leu Xaa 
65                  70                  75                  80  


Phe Xaa Asn Glu Lys Gly Glu Tyr Pro Ser Gly Ile Asn Xaa Trp Gln 
                85                  90                  95      


Phe Asn Phe Lys Phe Asn Leu Xaa Glu Asp Met Tyr Ser Gln Asp Ser 
            100                 105                 110         


Ile Asp Leu Leu Ala Asn Ser 
        115                 


<210> 6587
<211> 133
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<400> 6587
Met Pro Ala Ala Leu Val Glu Asn Ser Gln Val Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Ser Asn Leu Glu Glu Glu Met Arg Lys Ile Arg Glu Ile Val Leu 
            20                  25                  30          


Ser Tyr Ser Tyr Ile Ala Met Asp Xaa Glu Phe Pro Gly Val Val Val 
        35                  40                  45              


Arg Pro Ile Gly Glu Phe Arg Ser Ser Ile Asp Tyr Gln Tyr Gln Leu 
    50                  55                  60                  


Leu Arg Cys Asn Val Asp Leu Leu Lys Ile Ile Gln Leu Gly Leu Xaa 
65                  70                  75                  80  


Phe Xaa Asn Glu Lys Gly Glu Tyr Pro Ser Gly Ile Asn Xaa Trp Gln 
                85                  90                  95      


Phe Asn Phe Lys Phe Asn Leu Xaa Glu Asp Met Tyr Ser Gln Asp Ser 
            100                 105                 110         


Ile Asp Leu Leu Ala Asn Ser Gly Leu Gln Phe Gln Lys His Glu Glu 
        115                 120                 125             


Glu Gly Ile Asp Xaa 
    130             


<210> 6588
<211> 292
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<400> 6588
Met Pro Ala Ala Leu Val Glu Asn Ser Gln Val Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Ser Asn Leu Glu Glu Glu Met Arg Lys Ile Arg Glu Ile Val Leu 
            20                  25                  30          


Ser Tyr Ser Tyr Ile Ala Met Asp Xaa Glu Phe Pro Gly Val Val Val 
        35                  40                  45              


Arg Pro Ile Gly Glu Phe Arg Ser Ser Ile Asp Tyr Gln Tyr Gln Leu 
    50                  55                  60                  


Leu Arg Cys Asn Val Asp Leu Leu Lys Ile Ile Gln Leu Gly Leu Xaa 
65                  70                  75                  80  


Phe Xaa Asn Glu Lys Gly Glu Tyr Pro Ser Gly Ile Asn Xaa Trp Gln 
                85                  90                  95      


Phe Asn Phe Lys Phe Asn Leu Xaa Glu Asp Met Tyr Ser Gln Asp Ser 
            100                 105                 110         


Ile Asp Leu Leu Ala Asn Ser Gly Leu Gln Phe Gln Lys His Glu Glu 
        115                 120                 125             


Glu Gly Ile Asp Xaa Leu His Phe Ala Glu Leu Leu Met Xaa Ser Gly 
    130                 135                 140                 


Val Val Leu Cys Asp Asn Val Lys Trp Leu Ser Phe His Ser Gly Tyr 
145                 150                 155                 160 


Asp Phe Gly Tyr Met Val Lys Leu Leu Xaa Asp Ser Arg Leu Pro Glu 
                165                 170                 175     


Glu Glu His Glu Phe Phe His Ile Leu Asn Leu Phe Phe Pro Ser Ile 
            180                 185                 190         


Tyr Asp Val Lys Tyr Leu Met Lys Ser Cys Lys Asn Leu Lys Gly Gly 
        195                 200                 205             


Leu Gln Glu Val Ala Asp Gln Leu Asp Leu Gln Arg Ile Gly Arg Gln 
    210                 215                 220                 


His Gln Ala Gly Ser Asp Ser Leu Leu Xaa Gly Met Ala Phe Phe Arg 
225                 230                 235                 240 


Met Lys Glu Leu Phe Phe Glu Asp Ser Ile Asp Asp Ala Lys Tyr Cys 
                245                 250                 255     


Gly Arg Leu Tyr Gly Leu Gly Xaa Gly Val Ala Gln Lys Gln Asn Glu 
            260                 265                 270         


Asp Val Asp Ser Ala Gln Glu Lys Met Ser Ile Leu Ala Ile Ile Asn 
        275                 280                 285             


Asn Met Gln Gln 
    290         


<210> 6589
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 6589
Met Pro Ala Ala Leu Val Glu Asn Ser Gln Val Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Ser Asn Leu Glu Glu Glu Met Arg Lys Ile Arg Glu Ile Val Leu 
            20                  25                  30          


Ser Tyr Ser Tyr Ile Ala Met Asp Xaa Glu Phe Pro Gly Val Val Val 
        35                  40                  45              


Arg Pro Ile Gly Glu Phe Arg Ser Ser Ile Asp Tyr Gln Tyr Gln Leu 
    50                  55                  60                  


Leu Arg Cys Asn Val Asp Leu Leu Lys Ile Ile Gln Leu Gly Leu Xaa 
65                  70                  75                  80  


Phe Xaa Asn Glu Lys Gly Glu Tyr Pro Ser Gly Ile Asn Xaa Trp Gln 
                85                  90                  95      


Phe Asn Phe Lys Phe Asn Leu Xaa Gly Tyr Asp Phe Gly Tyr Met Val 
            100                 105                 110         


Lys Leu Leu Xaa Asp Ser Arg Leu Pro 
        115                 120     


<210> 6590
<211> 225
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<400> 6590
Met Pro Ala Ala Leu Val Glu Asn Ser Gln Val Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Ser Asn Leu Glu Glu Glu Met Arg Lys Ile Arg Glu Ile Val Leu 
            20                  25                  30          


Ser Tyr Ser Tyr Ile Ala Met Asp Xaa Glu Phe Pro Gly Val Val Val 
        35                  40                  45              


Arg Pro Ile Gly Glu Phe Arg Ser Ser Ile Asp Tyr Gln Tyr Gln Leu 
    50                  55                  60                  


Leu Arg Cys Asn Val Asp Leu Leu Lys Ile Ile Gln Leu Gly Leu Xaa 
65                  70                  75                  80  


Phe Xaa Asn Glu Lys Gly Glu Tyr Pro Ser Gly Ile Asn Xaa Trp Gln 
                85                  90                  95      


Phe Asn Phe Lys Phe Asn Leu Xaa Gly Tyr Asp Phe Gly Tyr Met Val 
            100                 105                 110         


Lys Leu Leu Xaa Asp Ser Arg Leu Pro Glu Glu Glu His Glu Phe Phe 
        115                 120                 125             


His Ile Leu Asn Leu Phe Phe Pro Ser Ile Tyr Asp Val Lys Tyr Leu 
    130                 135                 140                 


Met Lys Ser Cys Lys Asn Leu Lys Gly Gly Leu Gln Glu Val Ala Asp 
145                 150                 155                 160 


Gln Leu Asp Leu Gln Arg Ile Gly Arg Gln His Gln Ala Gly Ser Asp 
                165                 170                 175     


Ser Leu Leu Xaa Gly Met Ala Phe Phe Arg Met Lys Glu Leu Phe Phe 
            180                 185                 190         


Glu Asp Ser Ile Asp Asp Ala Lys Tyr Cys Gly Arg Leu Tyr Gly Leu 
        195                 200                 205             


Gly Xaa Gly Val Ala Gln Lys Gln Asn Glu Asp Val Asp Ser Ala Gln 
    210                 215                 220                 


Glu 
225 


<210> 6591
<211> 238
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<400> 6591
Met Pro Ala Ala Leu Val Glu Asn Ser Gln Val Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Ser Asn Leu Glu Glu Glu Met Arg Lys Ile Arg Glu Ile Val Leu 
            20                  25                  30          


Ser Tyr Ser Tyr Ile Ala Met Asp Xaa Glu Phe Pro Gly Val Val Val 
        35                  40                  45              


Arg Pro Ile Gly Glu Phe Arg Ser Ser Ile Asp Tyr Gln Tyr Gln Leu 
    50                  55                  60                  


Leu Arg Cys Asn Val Asp Leu Leu Lys Ile Ile Gln Leu Gly Leu Xaa 
65                  70                  75                  80  


Phe Xaa Asn Glu Lys Gly Glu Tyr Pro Ser Gly Ile Asn Xaa Trp Gln 
                85                  90                  95      


Phe Asn Phe Lys Phe Asn Leu Xaa Gly Tyr Asp Phe Gly Tyr Met Val 
            100                 105                 110         


Lys Leu Leu Xaa Asp Ser Arg Leu Pro Glu Glu Glu His Glu Phe Phe 
        115                 120                 125             


His Ile Leu Asn Leu Phe Phe Pro Ser Ile Tyr Asp Val Lys Tyr Leu 
    130                 135                 140                 


Met Lys Ser Cys Lys Asn Leu Lys Gly Gly Leu Gln Glu Val Ala Asp 
145                 150                 155                 160 


Gln Leu Asp Leu Gln Arg Ile Gly Arg Gln His Gln Ala Gly Ser Asp 
                165                 170                 175     


Ser Leu Leu Xaa Gly Met Ala Phe Phe Arg Met Lys Glu Leu Phe Phe 
            180                 185                 190         


Glu Asp Ser Ile Asp Asp Ala Lys Tyr Cys Gly Arg Leu Tyr Gly Leu 
        195                 200                 205             


Gly Xaa Gly Val Ala Gln Lys Gln Asn Glu Asp Val Asp Ser Ala Gln 
    210                 215                 220                 


Glu Lys Met Ser Ile Leu Ala Ile Ile Asn Asn Met Gln Gln 
225                 230                 235             


<210> 6592
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<400> 6592
Met Pro Ala Ala Leu Val Glu Asn Ser Gln Val Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Ser Asn Leu Glu Glu Glu Met Arg Lys Ile Arg Glu Ile Val Leu 
            20                  25                  30          


Ser Tyr Ser Tyr Ile Ala Met Asp Xaa Glu Phe Pro Gly Val Val Val 
        35                  40                  45              


Arg Pro Ile Gly Glu Phe Arg Ser Ser Ile Asp Tyr Gln Tyr Gln Leu 
    50                  55                  60                  


Leu Arg Cys Asn Val Asp Leu Leu Lys Ile Ile Gln Leu Gly Leu Xaa 
65                  70                  75                  80  


Phe Xaa Asn Glu Lys Gly Glu Tyr Pro Ser Gly Ile Asn Xaa Trp Gln 
                85                  90                  95      


Phe Asn Phe Lys Phe Asn Leu Xaa Tyr Lys Lys Glu Lys Val Asn Asn 
            100                 105                 110         


Asn Xaa Cys Val Ala 
        115         


<210> 6593
<211> 52
<212> PRT
<213> Homo sapiens

<400> 6593
Met Pro Ala Ala Leu Val Glu Asn Ser Gln Val Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Ser Asn Leu Glu Glu Glu Met Arg Lys Ile Arg Glu Ile Val Leu 
            20                  25                  30          


Ser Tyr Ser Tyr Ile Ala Met Arg Gly His Val Leu Pro Gly Phe His 
        35                  40                  45              


Arg Ser Pro Cys 
    50          


<210> 6594
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<400> 6594
Met Val Lys Leu Leu Xaa Asp Ser Arg Leu Pro Glu Glu Glu His Glu 
1               5                   10                  15      


Phe Phe His Ile Leu Asn Leu Phe Phe Pro Ser Ile Tyr Asp Val Lys 
            20                  25                  30          


Tyr Leu Met Lys Ser Cys Lys Asn Leu Lys Gly Gly Leu Gln Glu Val 
        35                  40                  45              


Ala Asp Gln Leu Asp Leu Gln Arg Ile Gly Arg Gln His Gln Ala Gly 
    50                  55                  60                  


Ser Asp Ser Leu Leu Xaa Gly Met Ala Phe Phe Arg Met Lys Glu Leu 
65                  70                  75                  80  


Phe Phe Glu Asp Ser Ile Asp Asp Ala Lys Tyr Cys Gly Arg Leu Tyr 
                85                  90                  95      


Gly Leu Gly Xaa Gly Val Ala Gln Lys Gln Asn Glu Asp Val Asp Ser 
            100                 105                 110         


Ala Gln Glu Lys Met Ser Ile Leu Ala Ile Ile Asn Asn Met Gln Gln 
        115                 120                 125             


<210> 6595
<211> 85
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 6595
Met Tyr Ser Gln Asp Ser Ile Asp Leu Leu Ala Asn Ser Gly Leu Gln 
1               5                   10                  15      


Phe Gln Lys His Glu Glu Glu Gly Ile Asp Xaa Leu His Phe Ala Glu 
            20                  25                  30          


Leu Leu Met Xaa Ser Gly Val Val Leu Cys Asp Asn Val Lys Trp Leu 
        35                  40                  45              


Ser Phe His Ser Gly Tyr Asp Phe Gly Tyr Met Val Lys Leu Leu Xaa 
    50                  55                  60                  


Asp Ser Arg Leu Pro Glu Glu Glu His Glu Phe Phe His Ile Leu Asn 
65                  70                  75                  80  


Leu Phe Phe Pro Ser 
                85  


<210> 6596
<211> 186
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<400> 6596
Met Tyr Ser Gln Asp Ser Ile Asp Leu Leu Ala Asn Ser Gly Leu Gln 
1               5                   10                  15      


Phe Gln Lys His Glu Glu Glu Gly Ile Asp Xaa Leu His Phe Ala Glu 
            20                  25                  30          


Leu Leu Met Xaa Ser Gly Val Val Leu Cys Asp Asn Val Lys Trp Leu 
        35                  40                  45              


Ser Phe His Ser Gly Tyr Asp Phe Gly Tyr Met Val Lys Leu Leu Xaa 
    50                  55                  60                  


Asp Ser Arg Leu Pro Glu Glu Glu His Glu Phe Phe His Ile Leu Asn 
65                  70                  75                  80  


Leu Phe Phe Pro Ser Ile Tyr Asp Val Lys Tyr Leu Met Lys Ser Cys 
                85                  90                  95      


Lys Asn Leu Lys Gly Gly Leu Gln Glu Val Ala Asp Gln Leu Asp Leu 
            100                 105                 110         


Gln Arg Ile Gly Arg Gln His Gln Ala Gly Ser Asp Ser Leu Leu Xaa 
        115                 120                 125             


Gly Met Ala Phe Phe Arg Met Lys Glu Leu Phe Phe Glu Asp Ser Ile 
    130                 135                 140                 


Asp Asp Ala Lys Tyr Cys Gly Arg Leu Tyr Gly Leu Gly Xaa Gly Val 
145                 150                 155                 160 


Ala Gln Lys Gln Asn Glu Asp Val Asp Ser Ala Gln Glu Lys Met Ser 
                165                 170                 175     


Ile Leu Ala Ile Ile Asn Asn Met Gln Gln 
            180                 185     


<210> 6597
<211> 61
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<400> 6597
Ile Leu Gln Lys Ile Leu Leu Asp Asp Xaa Gly Leu Ala Tyr Ile Cys 
1               5                   10                  15      


Gln Xaa Tyr Glu Arg Phe Ser His Val Ala Met Ile Leu Gly Lys Met 
            20                  25                  30          


Val Leu Gln Leu Ser Lys Glu Pro Ser Ala Arg Leu Leu Lys His Val 
        35                  40                  45              


Val Arg Cys Tyr Leu Arg Leu Ser Asp Asn Pro Arg Cys 
    50                  55                  60      


<210> 6598
<211> 41
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<400> 6598
Met His Ser Leu Ala Xaa Ala Ala Asp Leu Ala Leu Leu Pro Arg Leu 
1               5                   10                  15      


Glu Cys Ser Gly Val Ile Leu Ala His Arg Asn Leu Asp Leu Leu Gly 
            20                  25                  30          


Ser Val Asp Ser Pro Xaa Ser Ala Ser 
        35                  40      


<210> 6599
<211> 299
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<400> 6599
Met His Ser Leu Ala Xaa Ala Ala Pro Val Pro Xaa Xaa Leu Ala Gln 
1               5                   10                  15      


Val Asp Arg Glu Lys Ile Tyr Gln Trp Ile Asn Glu Leu Ser Ser Pro 
            20                  25                  30          


Glu Xaa Arg Glu Asn Ala Leu Leu Glu Leu Ser Lys Lys Arg Glu Ser 
        35                  40                  45              


Val Pro Asp Leu Ala Pro Met Leu Trp His Ser Phe Gly Xaa Ile Ala 
    50                  55                  60                  


Ala Leu Leu Gln Glu Ile Val Asn Ile Tyr Pro Ser Ile Asn Pro Pro 
65                  70                  75                  80  


Xaa Leu Xaa Ala His Gln Ser Asn Arg Val Cys Asn Ala Leu Ala Leu 
                85                  90                  95      


Leu Gln Cys Val Ala Ser His Pro Glu Xaa Arg Ser Ala Phe Leu Ala 
            100                 105                 110         


Ala His Ile Pro Leu Phe Leu Tyr Pro Phe Leu His Xaa Val Ser Lys 
        115                 120                 125             


Xaa Arg Pro Phe Glu Tyr Leu Arg Leu Xaa Ser Leu Gly Val Ile Gly 
    130                 135                 140                 


Ala Leu Val Lys Xaa Asp Glu Gln Glu Val Ile Asn Phe Leu Leu Xaa 
145                 150                 155                 160 


Xaa Glu Ile Ile Pro Leu Cys Leu Arg Ile Met Glu Ser Gly Ser Glu 
                165                 170                 175     


Leu Ser Lys Xaa Val Ala Xaa Phe Ile Leu Gln Lys Ile Leu Leu Asp 
            180                 185                 190         


Asp Xaa Gly Leu Ala Tyr Ile Cys Gln Xaa Tyr Glu Arg Phe Ser His 
        195                 200                 205             


Val Ala Met Ile Leu Gly Lys Met Val Leu Gln Leu Ser Lys Glu Pro 
    210                 215                 220                 


Ser Ala Arg Leu Leu Lys His Val Val Arg Cys Tyr Leu Arg Leu Ser 
225                 230                 235                 240 


Asp Asn Pro Arg Ala Arg Glu Ala Leu Arg Gln Cys Leu Pro Asp Gln 
                245                 250                 255     


Leu Lys Asp Xaa Xaa Phe Ala Gln Val Leu Lys Asp Asp Xaa Xaa Xaa 
            260                 265                 270         


Lys Arg Trp Leu Ala Gln Leu Val Lys Asn Leu Gln Glu Gly Gln Val 
        275                 280                 285             


Xaa Asp Pro Arg Gly Ile Pro Leu Pro Pro Gln 
    290                 295                 


<210> 6600
<211> 258
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<400> 6600
Met His Ser Leu Ala Xaa Ala Ala Pro Val Pro Xaa Xaa Leu Ala Gln 
1               5                   10                  15      


Val Asp Arg Glu Lys Ile Tyr Gln Trp Ile Asn Glu Leu Ser Ser Pro 
            20                  25                  30          


Glu Xaa Arg Glu Asn Ala Leu Leu Glu Leu Ser Lys Lys Arg Glu Ser 
        35                  40                  45              


Val Pro Asp Leu Ala Pro Met Leu Trp His Ser Phe Gly Xaa Ile Ala 
    50                  55                  60                  


Ala Leu Leu Gln Glu Ile Val Asn Ile Tyr Pro Ser Ile Asn Pro Pro 
65                  70                  75                  80  


Xaa Leu Xaa Ala His Gln Ser Asn Arg Val Cys Asn Ala Leu Ala Leu 
                85                  90                  95      


Leu Gln Cys Val Ala Ser His Pro Glu Xaa Arg Ser Ala Phe Leu Ala 
            100                 105                 110         


Ala His Ile Pro Leu Phe Leu Tyr Pro Phe Leu His Xaa Val Ser Lys 
        115                 120                 125             


Xaa Arg Pro Phe Glu Tyr Leu Arg Leu Xaa Ser Leu Gly Val Ile Gly 
    130                 135                 140                 


Ala Leu Val Lys Xaa Asp Glu Gln Glu Val Ile Asn Phe Leu Leu Xaa 
145                 150                 155                 160 


Xaa Glu Ile Ile Pro Leu Cys Leu Arg Ile Met Glu Ser Gly Ser Glu 
                165                 170                 175     


Leu Ser Lys Xaa Val Ala Xaa Phe Ile Leu Gln Lys Ile Leu Leu Asp 
            180                 185                 190         


Asp Xaa Gly Leu Ala Tyr Ile Cys Gln Xaa Tyr Glu Arg Phe Ser His 
        195                 200                 205             


Val Ala Met Ile Leu Gly Lys Met Val Leu Gln Leu Ser Lys Glu Pro 
    210                 215                 220                 


Ser Ala Arg Leu Leu Lys His Val Val Arg Cys Tyr Leu Arg Leu Ser 
225                 230                 235                 240 


Asp Asn Pro Arg Phe Ser Asp Leu Xaa Phe Cys Trp Ser Ser Phe Gln 
                245                 250                 255     


Arg Lys 
        


<210> 6601
<211> 331
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<400> 6601
Met His Ser Leu Ala Xaa Ala Ala Pro Val Pro Xaa Xaa Leu Ala Gln 
1               5                   10                  15      


Val Asp Arg Glu Lys Ile Tyr Gln Trp Ile Asn Glu Leu Ser Ser Pro 
            20                  25                  30          


Glu Xaa Arg Glu Asn Ala Leu Leu Glu Leu Ser Lys Lys Arg Glu Ser 
        35                  40                  45              


Val Pro Asp Leu Ala Pro Met Leu Trp His Ser Phe Gly Xaa Ile Ala 
    50                  55                  60                  


Ala Leu Leu Gln Glu Ile Val Asn Ile Tyr Pro Ser Ile Asn Pro Pro 
65                  70                  75                  80  


Xaa Leu Xaa Ala His Gln Ser Asn Arg Val Cys Asn Ala Leu Ala Leu 
                85                  90                  95      


Leu Gln Cys Val Ala Ser His Pro Glu Xaa Arg Ser Ala Phe Leu Ala 
            100                 105                 110         


Ala His Ile Pro Leu Phe Leu Tyr Pro Phe Leu His Xaa Val Ser Lys 
        115                 120                 125             


Xaa Arg Pro Phe Glu Tyr Leu Arg Leu Xaa Ser Leu Gly Val Ile Val 
    130                 135                 140                 


Glu Xaa Gly Phe His His Val Gly Gln Ala Asp Leu Glu Leu Pro Xaa 
145                 150                 155                 160 


Ser Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Xaa Gly 
                165                 170                 175     


Ala Leu Val Lys Xaa Asp Glu Gln Glu Val Ile Asn Phe Leu Leu Xaa 
            180                 185                 190         


Xaa Glu Ile Ile Pro Leu Cys Leu Arg Ile Met Glu Ser Gly Ser Glu 
        195                 200                 205             


Leu Ser Lys Xaa Val Ala Xaa Phe Ile Leu Gln Lys Ile Leu Leu Asp 
    210                 215                 220                 


Asp Xaa Gly Leu Ala Tyr Ile Cys Gln Xaa Tyr Glu Arg Phe Ser His 
225                 230                 235                 240 


Val Ala Met Ile Leu Gly Lys Met Val Leu Gln Leu Ser Lys Glu Pro 
                245                 250                 255     


Ser Ala Arg Leu Leu Lys His Val Val Arg Cys Tyr Leu Arg Leu Ser 
            260                 265                 270         


Asp Asn Pro Arg Ala Arg Glu Ala Leu Arg Gln Cys Leu Pro Asp Gln 
        275                 280                 285             


Leu Lys Asp Xaa Xaa Phe Ala Gln Val Leu Lys Asp Asp Xaa Xaa Xaa 
    290                 295                 300                 


Lys Arg Trp Leu Ala Gln Leu Val Lys Asn Leu Gln Glu Gly Gln Val 
305                 310                 315                 320 


Xaa Asp Pro Arg Gly Ile Pro Leu Pro Pro Gln 
                325                 330     


<210> 6602
<211> 75
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<400> 6602
Met His Ser Leu Ala Xaa Ala Ala Pro Val Pro Xaa Xaa Leu Ala Gln 
1               5                   10                  15      


Val Asp Arg Glu Lys Ile Tyr Gln Trp Ile Asn Glu Leu Ser Ser Pro 
            20                  25                  30          


Glu Xaa Arg Glu Asn Ala Leu Leu Glu Leu Ser Lys Lys Arg Glu Ser 
        35                  40                  45              


Val Pro Asp Leu Ala Pro Met Leu Trp His Ser Phe Gly Xaa Ile Ala 
    50                  55                  60                  


Ala Leu Leu Gln Val Ile Val Met Gln Val Ile 
65                  70                  75  


<210> 6603
<211> 145
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<400> 6603
Met Asp Glu Ile Glu His Asp Ile Xaa Lys Ala Arg Gln Lys Lys Xaa 
1               5                   10                  15      


Lys Val Gly Ser Phe Arg Ile Asn Pro Asp Gly Xaa Gln Glu Arg Arg 
            20                  25                  30          


Lys Ile Pro Leu Ala Gln Ser Glu Ala Phe Leu Xaa Asp Leu Leu Glu 
        35                  40                  45              


Lys Val Cys Glu Arg Met Asn Asp Tyr Lys Leu Glu Glu Asp Pro Val 
    50                  55                  60                  


Xaa Lys Glu Arg Xaa Phe Lys Arg Phe Ala Pro Arg Lys Gly Asp Lys 
65                  70                  75                  80  


Ile Tyr Gln Glu Phe Lys Lys Leu Tyr Phe Tyr Ser Asp Ala Tyr Arg 
                85                  90                  95      


Pro Leu Lys Phe Ala Cys Glu Xaa Ile Ile Glu Glu Tyr Glu Asp Glu 
            100                 105                 110         


Ile Ser Ser Leu Ile Ala Gln Glu Xaa His Tyr Leu Ala Asp Lys Leu 
        115                 120                 125             


Cys Ser Glu Lys Ser Asp Leu Cys Glu Xaa Ser Ala Asn His Xaa Glu 
    130                 135                 140                 


Leu 
145 


<210> 6604
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<400> 6604
Met Asn Asp Tyr Lys Leu Glu Glu Asp Pro Val Xaa Lys Glu Arg Xaa 
1               5                   10                  15      


Phe Lys Arg Phe Ala Pro Arg Lys Gly Asp Lys Ile Tyr Gln Glu Phe 
            20                  25                  30          


Lys Lys Leu Tyr Phe Tyr Ser Asp Ala Tyr Arg Pro Leu Lys Phe Ala 
        35                  40                  45              


Cys Glu Xaa Ile Ile Glu Glu Tyr Glu Asp Glu Ile Ser Ser Leu Ile 
    50                  55                  60                  


Ala Gln Glu Xaa His Tyr Leu Ala Asp Lys Leu Cys Ser Glu Lys Ser 
65                  70                  75                  80  


Asp Leu Cys Glu Xaa Ser Ala Asn His Xaa Glu Leu 
                85                  90          


<210> 6605
<211> 80
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<400> 6605
Lys Asn Tyr Val Arg Val Val Gly Arg Asn Gly Glu Ser Ser Glu Leu 
1               5                   10                  15      


Asp Leu Gln Gly Ile Arg Ile Asp Ser Asp Ile Ser Gly Xaa Leu Lys 
            20                  25                  30          


Phe Ala Cys Glu Ser Ile Val Glu Glu Tyr Glu Asp Glu Leu Ile Glu 
        35                  40                  45              


Phe Phe Ser Arg Glu Ala Asp Asn Val Lys Asp Lys Leu Cys Ser Lys 
    50                  55                  60                  


Arg Xaa Asp Leu Cys Asp His Ala Leu His Ile Ser His Asp Glu Leu 
65                  70                  75                  80  


<210> 6606
<211> 102
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 6606
Met Gly Ser Phe Arg Ile Asn Pro Asp Gly Ser Gln Ser Val Val Glu 
1               5                   10                  15      


Val Pro Tyr Ala Arg Ser Glu Ala His Leu Xaa Glu Leu Leu Glu Glu 
            20                  25                  30          


Ile Cys Asp Arg Met Lys Glu Tyr Gly Glu Gln Ile Asp Pro Ser Xaa 
        35                  40                  45              


His Arg Lys Asn Tyr Val Arg Val Val Gly Arg Asn Gly Glu Ser Ser 
    50                  55                  60                  


Glu Leu Asp Leu Gln Gly Ile Arg Ile Asp Ser Asp Ile Ser Gly Xaa 
65                  70                  75                  80  


Leu Lys Phe Ala Cys Glu Ser Ile Val Glu Glu Tyr Glu Asp Glu Leu 
                85                  90                  95      


Ile Glu Phe Phe Ser Arg 
            100         


<210> 6607
<211> 168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<400> 6607
Met Lys Gly Trp Gly Trp Leu Ala Leu Leu Leu Gly Ala Leu Leu Gly 
1               5                   10                  15      


Xaa Ala Trp Ala Arg Arg Ser Gln Asp Leu His Cys Gly Ala Cys Arg 
            20                  25                  30          


Ala Leu Val Asp Glu Leu Glu Trp Glu Ile Ala Gln Val Asp Pro Lys 
        35                  40                  45              


Lys Xaa Ile Gln Met Gly Ser Phe Arg Ile Asn Pro Asp Gly Ser Gln 
    50                  55                  60                  


Ser Val Val Glu Val Pro Tyr Ala Arg Ser Glu Ala His Leu Xaa Glu 
65                  70                  75                  80  


Leu Leu Glu Glu Ile Cys Asp Arg Met Lys Glu Tyr Gly Glu Gln Ile 
                85                  90                  95      


Asp Pro Ser Xaa His Arg Lys Asn Tyr Val Arg Val Val Gly Arg Asn 
            100                 105                 110         


Gly Glu Ser Ser Glu Leu Asp Leu Gln Gly Ile Arg Ile Asp Ser Asp 
        115                 120                 125             


Ile Ser Gly Xaa Leu Lys Phe Ala Cys Glu Ser Ile Val Glu Glu Tyr 
    130                 135                 140                 


Glu Asp Glu Leu Ile Glu Phe Phe Ser Arg Glu Ala Asp Asn Val Lys 
145                 150                 155                 160 


Asp Lys Leu Cys Ser Lys Arg Xaa 
                165             


<210> 6608
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<400> 6608
Met Lys Gly Trp Gly Trp Leu Ala Leu Leu Leu Gly Ala Leu Leu Gly 
1               5                   10                  15      


Xaa Ala Trp Ala Arg Arg Ser Gln Asp Leu His Cys Gly Ala Cys Arg 
            20                  25                  30          


Ala Leu Val Asp Glu Leu Glu Trp Glu Ile Ala Gln Val Asp Pro Lys 
        35                  40                  45              


Lys Xaa Ile Gln Met Gly Ser Phe Arg Ile Asn Pro Asp Gly Ser Gln 
    50                  55                  60                  


Ser Val Val Glu Val Pro Tyr Ala Arg Ser Glu Ala His Leu Xaa Glu 
65                  70                  75                  80  


Leu Leu Glu Glu Ile Cys Asp Arg Met Lys Glu Tyr Gly Glu Gln Ile 
                85                  90                  95      


Asp Pro Ser Xaa His Arg Lys Asn Tyr Val Arg Val Val Gly Arg Asn 
            100                 105                 110         


Gly Glu Ser Ser Glu Leu Asp Leu Gln Gly Ile Arg Ile Asp Ser Asp 
        115                 120                 125             


Ile Ser Gly Xaa Leu Lys Phe Ala Cys Glu Ser Ile Val Glu Glu Tyr 
    130                 135                 140                 


Glu Asp Glu Leu Ile Glu Phe Phe Ser Arg Glu Ala Asp Asn Val Lys 
145                 150                 155                 160 


Asp Lys Leu Cys Ser Lys Arg Xaa Asp Leu Cys Asp His Ala Leu His 
                165                 170                 175     


Ile Ser His Asp Glu Leu 
            180         


<210> 6609
<211> 41
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<400> 6609
Xaa Ala Cys Arg Ala Leu Val Asp Glu Leu Glu Trp Glu Ile Ala Gln 
1               5                   10                  15      


Val Asp Pro Lys Lys Xaa Ile Gln Met Gly Ser Phe Arg Ile Asn Pro 
            20                  25                  30          


Asp Gly Ser Gln Ser Val Val Glu Arg 
        35                  40      


<210> 6610
<211> 278
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<400> 6610
Met Asp Ser Met Pro Glu Pro Ala Ser Arg Cys Leu Leu Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Ala Pro Glu Leu Gly Pro 
            20                  25                  30          


Ser Gln Ala Gly Ala Glu Glu Asn Asp Trp Val Arg Leu Pro Ser Lys 
        35                  40                  45              


Cys Glu Val Cys Lys Tyr Val Ala Val Glu Leu Lys Ser Ala Phe Glu 
    50                  55                  60                  


Glu Xaa Gly Lys Xaa Lys Glu Val Ile Gly Xaa Gly Tyr Gly Ile Leu 
65                  70                  75                  80  


Asp Gln Lys Ala Ser Gly Val Lys Tyr Xaa Lys Ser Asp Leu Arg Leu 
                85                  90                  95      


Ile Glu Val Xaa Glu Xaa Ile Cys Lys Arg Leu Leu Asp Tyr Ser Leu 
            100                 105                 110         


His Lys Glu Arg Xaa Gly Ser Asn Arg Phe Ala Lys Gly Met Ser Glu 
        115                 120                 125             


Xaa Phe Glu Xaa Leu His Asn Leu Val His Lys Gly Val Lys Val Val 
    130                 135                 140                 


Met Asp Ile Pro Tyr Glu Leu Trp Asn Glu Xaa Ser Ala Glu Val Ala 
145                 150                 155                 160 


Asp Leu Lys Lys Gln Cys Asp Val Leu Val Glu Glu Phe Glu Glu Val 
                165                 170                 175     


Ile Glu Asp Trp Tyr Arg Asn His Gln Glu Glu Asp Leu Xaa Glu Phe 
            180                 185                 190         


Leu Cys Ala Asn His Val Leu Lys Gly Lys Asp Xaa Ser Cys Leu Ala 
        195                 200                 205             


Glu Gln Trp Ser Gly Lys Lys Gly Asp Xaa Ala Ala Leu Gly Gly Lys 
    210                 215                 220                 


Lys Ser Lys Lys Lys Ser Ser Arg Ala Lys Ala Ala Gly Gly Arg Ser 
225                 230                 235                 240 


Ser Ser Ser Lys Gln Arg Lys Glu Leu Gly Gly Leu Glu Gly Asp Pro 
                245                 250                 255     


Ser Pro Glu Glu Asp Glu Gly Ile Gln Lys Ala Ser Pro Leu Xaa His 
            260                 265                 270         


Ser Pro Pro Asp Glu Leu 
        275             


<210> 6611
<211> 143
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<400> 6611
Met Asp Ser Met Pro Glu Pro Ala Ser Arg Cys Leu Leu Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Ala Pro Glu Leu Gly Pro 
            20                  25                  30          


Ser Gln Ala Gly Ala Glu Glu Asn Asp Trp Val Arg Leu Pro Ser Lys 
        35                  40                  45              


Cys Glu Val Cys Lys Tyr Val Ala Val Glu Leu Lys Ser Ala Phe Glu 
    50                  55                  60                  


Glu Xaa Gly Lys Xaa Lys Glu Val Ile Gly Xaa Gly Tyr Gly Ile Leu 
65                  70                  75                  80  


Asp Gln Lys Ala Ser Gly Val Lys Tyr Xaa Lys Ser Asp Leu Arg Leu 
                85                  90                  95      


Ile Glu Val Xaa Glu Xaa Ile Cys Lys Arg Leu Leu Ile Ile Ala Cys 
            100                 105                 110         


Xaa Arg Arg Gly Pro Ala Ala Ile Asp Leu Pro Arg Ala Cys Gln Arg 
        115                 120                 125             


Pro Leu Arg His Tyr Xaa Xaa Trp Tyr Xaa Lys Gly Ser Arg Trp 
    130                 135                 140             


<210> 6612
<211> 439
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<400> 6612
Met Lys Ser Ile Leu Asp Gly Leu Ala Asp Xaa Xaa Phe Arg Xaa Ile 
1               5                   10                  15      


Xaa Xaa Asp Leu Leu Gly Ser Pro Phe Gln Glu Lys Met Xaa Ala Gly 
            20                  25                  30          


Asp Asn Pro Gln Leu Val Pro Ala Asp Gln Val Asn Ile Xaa Glu Phe 
        35                  40                  45              


Tyr Asn Lys Ser Leu Ser Ser Phe Lys Glu Asn Glu Glu Asn Ile Gln 
    50                  55                  60                  


Cys Gly Glu Asn Phe Met Asp Ile Glu Cys Phe Met Val Leu Asn Pro 
65                  70                  75                  80  


Ser Gln Gln Leu Ala Ile Ala Val Leu Ser Leu Xaa Leu Gly Xaa Phe 
                85                  90                  95      


Xaa Val Leu Glu Asn Leu Leu Val Leu Cys Val Ile Leu His Ser Arg 
            100                 105                 110         


Ser Leu Arg Cys Arg Pro Ser Tyr His Phe Ile Gly Ser Leu Ala Val 
        115                 120                 125             


Ala Asp Leu Leu Gly Ser Val Ile Phe Val Tyr Ser Phe Ile Asp Phe 
    130                 135                 140                 


His Val Phe His Arg Lys Asp Ser Arg Asn Val Phe Leu Phe Lys Leu 
145                 150                 155                 160 


Gly Gly Val Xaa Ala Ser Phe Xaa Ala Ser Val Gly Ser Leu Phe Leu 
                165                 170                 175     


Xaa Ala Ile Asp Arg Tyr Ile Ser Ile His Arg Pro Leu Ala Tyr Lys 
            180                 185                 190         


Arg Ile Val Xaa Arg Pro Lys Ala Val Val Ala Phe Cys Leu Met Trp 
        195                 200                 205             


Xaa Ile Ala Ile Val Ile Ala Val Leu Pro Leu Leu Gly Trp Asn Cys 
    210                 215                 220                 


Glu Lys Leu Gln Ser Val Cys Ser Asp Ile Phe Pro His Ile Asp Glu 
225                 230                 235                 240 


Xaa Tyr Leu Met Phe Trp Ile Gly Val Xaa Ser Val Leu Leu Leu Phe 
                245                 250                 255     


Ile Val Tyr Ala Tyr Met Tyr Ile Leu Trp Lys Ala His Ser His Ala 
            260                 265                 270         


Val Arg Met Ile Gln Arg Gly Xaa Gln Lys Ser Ile Ile Ile His Xaa 
        275                 280                 285             


Ser Glu Asp Gly Lys Val Gln Val Xaa Arg Pro Asp Gln Ala Arg Met 
    290                 295                 300                 


Asp Ile Arg Leu Ala Lys Xaa Leu Val Leu Ile Leu Val Val Leu Ile 
305                 310                 315                 320 


Ile Cys Trp Gly Pro Leu Leu Ala Ile Met Val Tyr Asp Val Phe Gly 
                325                 330                 335     


Lys Met Asn Lys Leu Ile Lys Xaa Val Phe Ala Phe Cys Ser Met Leu 
            340                 345                 350         


Cys Leu Leu Asn Ser Xaa Val Asn Pro Ile Ile Tyr Ala Leu Arg Ser 
        355                 360                 365             


Lys Asp Leu Arg His Ala Phe Arg Ser Met Phe Pro Ser Cys Glu Gly 
    370                 375                 380                 


Xaa Ala Gln Pro Leu Asp Asn Ser Met Gly Asp Ser Asp Cys Leu His 
385                 390                 395                 400 


Lys His Ala Asn Asn Ala Ala Ser Val His Arg Ala Ala Glu Ser Cys 
                405                 410                 415     


Ile Lys Ser Xaa Val Lys Ile Ala Lys Val Xaa Met Ser Val Ser Xaa 
            420                 425                 430         


Asp Xaa Ser Ala Glu Ala Leu 
        435                 


<210> 6613
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<400> 6613
Met Lys Ser Ile Leu Asp Gly Leu Ala Asp Xaa Xaa Phe Arg Xaa Ile 
1               5                   10                  15      


Xaa Xaa Asp Leu Leu Tyr Val Gly Ser Asn Asp Ile Gln Tyr Glu Asp 
            20                  25                  30          


Ile Lys Gly Asp Met Ala Ser Lys Leu Gly Tyr Phe Pro Gln Lys Phe 
        35                  40                  45              


Pro Leu Xaa Ser Phe Arg Gly Ser Pro Phe Gln Glu Lys Met Xaa Ala 
    50                  55                  60                  


Gly Asp Asn Pro Gln Leu Val Pro Ala Asp Gln Val Asn Ile 
65                  70                  75              


<210> 6614
<211> 472
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<400> 6614
Met Lys Ser Ile Leu Asp Gly Leu Ala Asp Xaa Xaa Phe Arg Xaa Ile 
1               5                   10                  15      


Xaa Xaa Asp Leu Leu Tyr Val Gly Ser Asn Asp Ile Gln Tyr Glu Asp 
            20                  25                  30          


Ile Lys Gly Asp Met Ala Ser Lys Leu Gly Tyr Phe Pro Gln Lys Phe 
        35                  40                  45              


Pro Leu Xaa Ser Phe Arg Gly Ser Pro Phe Gln Glu Lys Met Xaa Ala 
    50                  55                  60                  


Gly Asp Asn Pro Gln Leu Val Pro Ala Asp Gln Val Asn Ile Xaa Glu 
65                  70                  75                  80  


Phe Tyr Asn Lys Ser Leu Ser Ser Phe Lys Glu Asn Glu Glu Asn Ile 
                85                  90                  95      


Gln Cys Gly Glu Asn Phe Met Asp Ile Glu Cys Phe Met Val Leu Asn 
            100                 105                 110         


Pro Ser Gln Gln Leu Ala Ile Ala Val Leu Ser Leu Xaa Leu Gly Xaa 
        115                 120                 125             


Phe Xaa Val Leu Glu Asn Leu Leu Val Leu Cys Val Ile Leu His Ser 
    130                 135                 140                 


Arg Ser Leu Arg Cys Arg Pro Ser Tyr His Phe Ile Gly Ser Leu Ala 
145                 150                 155                 160 


Val Ala Asp Leu Leu Gly Ser Val Ile Phe Val Tyr Ser Phe Ile Asp 
                165                 170                 175     


Phe His Val Phe His Arg Lys Asp Ser Arg Asn Val Phe Leu Phe Lys 
            180                 185                 190         


Leu Gly Gly Val Xaa Ala Ser Phe Xaa Ala Ser Val Gly Ser Leu Phe 
        195                 200                 205             


Leu Xaa Ala Ile Asp Arg Tyr Ile Ser Ile His Arg Pro Leu Ala Tyr 
    210                 215                 220                 


Lys Arg Ile Val Xaa Arg Pro Lys Ala Val Val Ala Phe Cys Leu Met 
225                 230                 235                 240 


Trp Xaa Ile Ala Ile Val Ile Ala Val Leu Pro Leu Leu Gly Trp Asn 
                245                 250                 255     


Cys Glu Lys Leu Gln Ser Val Cys Ser Asp Ile Phe Pro His Ile Asp 
            260                 265                 270         


Glu Xaa Tyr Leu Met Phe Trp Ile Gly Val Xaa Ser Val Leu Leu Leu 
        275                 280                 285             


Phe Ile Val Tyr Ala Tyr Met Tyr Ile Leu Trp Lys Ala His Ser His 
    290                 295                 300                 


Ala Val Arg Met Ile Gln Arg Gly Xaa Gln Lys Ser Ile Ile Ile His 
305                 310                 315                 320 


Xaa Ser Glu Asp Gly Lys Val Gln Val Xaa Arg Pro Asp Gln Ala Arg 
                325                 330                 335     


Met Asp Ile Arg Leu Ala Lys Xaa Leu Val Leu Ile Leu Val Val Leu 
            340                 345                 350         


Ile Ile Cys Trp Gly Pro Leu Leu Ala Ile Met Val Tyr Asp Val Phe 
        355                 360                 365             


Gly Lys Met Asn Lys Leu Ile Lys Xaa Val Phe Ala Phe Cys Ser Met 
    370                 375                 380                 


Leu Cys Leu Leu Asn Ser Xaa Val Asn Pro Ile Ile Tyr Ala Leu Arg 
385                 390                 395                 400 


Ser Lys Asp Leu Arg His Ala Phe Arg Ser Met Phe Pro Ser Cys Glu 
                405                 410                 415     


Gly Xaa Ala Gln Pro Leu Asp Asn Ser Met Gly Asp Ser Asp Cys Leu 
            420                 425                 430         


His Lys His Ala Asn Asn Ala Ala Ser Val His Arg Ala Ala Glu Ser 
        435                 440                 445             


Cys Ile Lys Ser Xaa Val Lys Ile Ala Lys Val Xaa Met Ser Val Ser 
    450                 455                 460                 


Xaa Asp Xaa Ser Ala Glu Ala Leu 
465                 470         


<210> 6615
<211> 36
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(18)
<223> Selenocysteine

<400> 6615
Met Lys Ser Ile Leu Asp Gly Leu Ala Asp Xaa Xaa Phe Arg Xaa Ile 
1               5                   10                  15      


Xaa Xaa Asp Leu Leu Tyr Val Gly Ser Asn Asp Ile Gln Tyr Glu Asp 
            20                  25                  30          


Ile Lys Gly Glu 
        35      


<210> 6616
<211> 360
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<400> 6616
Met Glu Glu Cys Trp Val Xaa Glu Ile Ala Asn Gly Ser Lys Asp Gly 
1               5                   10                  15      


Leu Asp Ser Asn Pro Met Lys Asp Tyr Met Ile Leu Ser Gly Pro Gln 
            20                  25                  30          


Lys Xaa Ala Val Ala Val Leu Cys Xaa Leu Leu Gly Leu Leu Ser Ala 
        35                  40                  45              


Leu Glu Asn Val Ala Val Leu Tyr Leu Ile Leu Ser Ser His Gln Leu 
    50                  55                  60                  


Arg Arg Lys Pro Ser Tyr Leu Phe Ile Gly Ser Leu Ala Gly Ala Asp 
65                  70                  75                  80  


Phe Leu Ala Ser Val Val Phe Ala Cys Ser Phe Val Asn Phe His Val 
                85                  90                  95      


Phe His Gly Val Asp Ser Lys Ala Val Phe Leu Leu Lys Ile Gly Ser 
            100                 105                 110         


Val Xaa Met Xaa Phe Xaa Ala Ser Val Gly Ser Leu Leu Leu Xaa Ala 
        115                 120                 125             


Ile Asp Arg Tyr Leu Cys Leu Arg Tyr Pro Pro Ser Tyr Lys Ala Leu 
    130                 135                 140                 


Leu Xaa Arg Gly Arg Ala Leu Val Xaa Leu Gly Ile Met Trp Val Leu 
145                 150                 155                 160 


Ser Ala Leu Val Ser Tyr Leu Pro Leu Met Gly Trp Xaa Cys Cys Pro 
                165                 170                 175     


Arg Pro Cys Ser Glu Leu Phe Pro Leu Ile Pro Asn Asp Tyr Leu Leu 
            180                 185                 190         


Ser Trp Leu Leu Phe Ile Ala Phe Leu Phe Ser Gly Ile Ile Tyr Xaa 
        195                 200                 205             


Tyr Gly His Val Leu Trp Lys Ala His Gln His Val Ala Ser Leu Ser 
    210                 215                 220                 


Gly His Gln Asp Arg Gln Val Pro Gly Met Ala Arg Met Arg Leu Asp 
225                 230                 235                 240 


Val Arg Leu Ala Lys Xaa Leu Gly Leu Val Leu Ala Val Leu Leu Ile 
                245                 250                 255     


Cys Trp Phe Pro Val Leu Ala Leu Met Ala His Ser Leu Ala Xaa Xaa 
            260                 265                 270         


Leu Ser Asp Gln Val Lys Lys Ala Phe Ala Phe Cys Ser Met Leu Cys 
        275                 280                 285             


Leu Ile Asn Ser Met Val Asn Pro Val Ile Tyr Ala Leu Arg Ser Gly 
    290                 295                 300                 


Glu Ile Arg Ser Ser Ala His His Cys Leu Ala His Trp Lys Lys Cys 
305                 310                 315                 320 


Val Arg Gly Leu Gly Ser Glu Ala Lys Glu Glu Ala Pro Arg Ser Ser 
                325                 330                 335     


Val Xaa Glu Xaa Glu Ala Asp Gly Lys Ile Xaa Pro Trp Pro Asp Ser 
            340                 345                 350         


Arg Asp Leu Asp Leu Ser Asp Cys 
        355                 360 


<210> 6617
<211> 200
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<400> 6617
Met Ala Phe Xaa Glu His Ser Pro Leu Xaa Pro His Arg Arg Asp Leu 
1               5                   10                  15      


Cys Ser Arg Ser Ile Trp Leu Ala Arg Lys Ile Arg Ser Asp Leu Xaa 
            20                  25                  30          


Ala Leu Xaa Glu Ser Tyr Val Lys His Gln Gly Leu Asn Lys Asn Ile 
        35                  40                  45              


Asn Leu Asp Ser Ala Asp Gly Met Pro Val Ala Ser Xaa Asp Gln Trp 
    50                  55                  60                  


Ser Glu Leu Xaa Glu Ala Glu Arg Leu Gln Glu Asn Leu Gln Ala Tyr 
65                  70                  75                  80  


Arg Xaa Phe His Val Leu Leu Ala Arg Leu Leu Glu Asp Gln Gln Val 
                85                  90                  95      


His Phe Xaa Pro Xaa Glu Gly Asp Phe His Gln Ala Ile His Xaa Leu 
            100                 105                 110         


Leu Leu Gln Val Ala Ala Phe Ala Tyr Gln Ile Glu Glu Leu Met Ile 
        115                 120                 125             


Leu Leu Glu Tyr Lys Ile Pro Arg Asn Glu Ala Asp Gly Met Pro Ile 
    130                 135                 140                 


Asn Val Gly Asp Gly Gly Leu Phe Glu Lys Lys Leu Trp Gly Leu Lys 
145                 150                 155                 160 


Val Leu Gln Glu Leu Ser Gln Trp Xaa Val Arg Ser Ile His Asp Leu 
                165                 170                 175     


Arg Phe Ile Ser Ser His Gln Xaa Gly Ile Pro Ala Arg Gly Ser His 
            180                 185                 190         


Tyr Ile Ala Asn Asn Lys Lys Met 
        195                 200 


<210> 6618
<211> 256
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<400> 6618
Met Ala Ala Pro Val Pro Trp Ala Cys Cys Ala Val Leu Ala Ala Ala 
1               5                   10                  15      


Ala Ala Val Val Tyr Ala Gln Arg His Ser Pro Gln Glu Ala Pro His 
            20                  25                  30          


Val Gln Tyr Glu Arg Leu Gly Ser Asp Val Xaa Leu Pro Cys Gly Xaa 
        35                  40                  45              


Ala Asn Trp Asp Ala Ala Val Xaa Trp Arg Val Asn Gly Xaa Asp Leu 
    50                  55                  60                  


Ala Pro Asp Leu Leu Asn Gly Ser Gln Leu Val Leu His Gly Leu Glu 
65                  70                  75                  80  


Leu Gly His Ser Gly Leu Tyr Ala Cys Phe His Arg Asp Ser Trp His 
                85                  90                  95      


Leu Arg His Gln Val Leu Leu His Val Gly Leu Pro Pro Arg Glu Pro 
            100                 105                 110         


Val Leu Ser Cys Arg Ser Asn Xaa Tyr Pro Lys Gly Phe Tyr Cys Ser 
        115                 120                 125             


Trp His Leu Pro Xaa Pro Xaa Tyr Ile Pro Asn Xaa Phe Asn Val Xaa 
    130                 135                 140                 


Val Leu His Gly Ser Lys Ile Met Val Cys Glu Lys Asp Pro Ala Leu 
145                 150                 155                 160 


Lys Asn Arg Cys His Ile Arg Tyr Met His Leu Phe Ser Xaa Ile Lys 
                165                 170                 175     


Tyr Lys Val Ser Ile Ser Val Ser Asn Ala Leu Gly His Asn Ala Xaa 
            180                 185                 190         


Ala Ile Xaa Phe Asp Glu Phe Xaa Ile Val Lys Pro Asp Pro Pro Glu 
        195                 200                 205             


Asn Val Val Ala Arg Pro Val Pro Ser Asn Pro Arg Arg Leu Glu Val 
    210                 215                 220                 


Xaa Trp Gln Xaa Pro Ser Xaa Trp Pro Asp Pro Glu Ser Phe Pro Leu 
225                 230                 235                 240 


Lys Phe Phe Leu Arg Tyr Arg Pro Leu Ile Leu Asp Gln Trp Gln His 
                245                 250                 255     


<210> 6619
<211> 372
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<400> 6619
Met Ala Ala Pro Val Pro Trp Ala Cys Cys Ala Val Leu Ala Ala Ala 
1               5                   10                  15      


Ala Ala Val Val Tyr Ala Gln Arg His Ser Pro Gln Glu Ala Pro His 
            20                  25                  30          


Val Gln Tyr Glu Arg Leu Gly Ser Asp Val Xaa Leu Pro Cys Gly Xaa 
        35                  40                  45              


Ala Asn Trp Asp Ala Ala Val Xaa Trp Arg Val Asn Gly Xaa Asp Leu 
    50                  55                  60                  


Ala Pro Asp Leu Leu Asn Gly Ser Gln Leu Val Leu His Gly Leu Glu 
65                  70                  75                  80  


Leu Gly His Ser Gly Leu Tyr Ala Cys Phe His Arg Asp Ser Trp His 
                85                  90                  95      


Leu Arg His Gln Val Leu Leu His Val Gly Leu Pro Pro Arg Glu Pro 
            100                 105                 110         


Val Leu Ser Cys Arg Ser Asn Xaa Tyr Pro Lys Gly Phe Tyr Cys Ser 
        115                 120                 125             


Trp His Leu Pro Xaa Pro Xaa Tyr Ile Pro Asn Xaa Phe Asn Val Xaa 
    130                 135                 140                 


Val Leu His Gly Ser Lys Ile Met Val Cys Glu Lys Asp Pro Ala Leu 
145                 150                 155                 160 


Lys Asn Arg Cys His Ile Arg Tyr Met His Leu Phe Ser Xaa Ile Lys 
                165                 170                 175     


Tyr Lys Val Ser Ile Ser Val Ser Asn Ala Leu Gly His Asn Ala Xaa 
            180                 185                 190         


Ala Ile Xaa Phe Asp Glu Phe Xaa Ile Val Lys Pro Asp Pro Pro Glu 
        195                 200                 205             


Asn Val Val Ala Arg Pro Val Pro Ser Asn Pro Arg Arg Leu Glu Val 
    210                 215                 220                 


Xaa Trp Gln Xaa Pro Ser Xaa Trp Pro Asp Pro Glu Ser Phe Pro Leu 
225                 230                 235                 240 


Lys Phe Phe Leu Arg Tyr Arg Pro Leu Ile Leu Asp Gln Trp Gln His 
                245                 250                 255     


Val Glu Leu Ser Asp Gly Xaa Ala His Xaa Ile Xaa Asp Ala Tyr Ala 
            260                 265                 270         


Gly Lys Glu Tyr Ile Ile Gln Val Ala Ala Lys Asp Asn Glu Ile Gly 
        275                 280                 285             


Xaa Trp Ser Asp Trp Ser Val Ala Ala His Ala Xaa Pro Trp Xaa Glu 
    290                 295                 300                 


Glu Pro Arg His Leu Xaa Xaa Glu Ala Gln Ala Ala Glu Xaa Xaa Xaa 
305                 310                 315                 320 


Ser Xaa Xaa Ser Ser Leu Ala Pro Pro Pro Xaa Xaa Lys Ile Cys Asp 
                325                 330                 335     


Pro Gly Glu Leu Gly Ser Gly Gly Gly Pro Ser Ala Pro Phe Leu Val 
            340                 345                 350         


Ser Val Pro Ile Xaa Leu Ala Leu Ala Ala Ala Ala Ala Xaa Ala Ser 
        355                 360                 365             


Ser Leu Leu Ile 
    370         


<210> 6620
<211> 57
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<400> 6620
Lys His Ser Ile Glu Val Pro Ile Pro Arg Asp Gly Glu Tyr Val Val 
1               5                   10                  15      


Glu Val Arg Ala His Ser Asp Gly Gly Asp Gly Val Val Ser Gln Val 
            20                  25                  30          


Lys Ile Ser Glu Gly Lys Ser Xaa Ser Leu Arg Ser Lys Xaa Ala Lys 
        35                  40                  45              


Asp His Arg Ser Ile Arg Xaa Met Ser 
    50                  55          


<210> 6621
<211> 63
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 6621
Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Xaa 
1               5                   10                  15      


Xaa Cys Leu Ala Glu Phe Xaa Trp Tyr Arg Arg Tyr Gly His Gly Val 
            20                  25                  30          


Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe Glu Glu Gln Pro Ile 
        35                  40                  45              


Asn Xaa Ile Tyr Pro Glu Glu Ser Leu Glu Gly Lys Val Ser Leu 
    50                  55                  60              


<210> 6622
<211> 73
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 6622
Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Xaa 
1               5                   10                  15      


Xaa Cys Leu Ala Glu Phe Xaa Trp Tyr Arg Arg Tyr Gly His Gly Val 
            20                  25                  30          


Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe Glu Glu Gln Pro Ile 
        35                  40                  45              


Asn Xaa Ile Tyr Pro Glu Glu Ser Leu Glu Gly Lys Val Ser Leu Asn 
    50                  55                  60                  


Cys Arg Ala Arg Ala Ser Pro Phe Pro 
65                  70              


<210> 6623
<211> 85
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 6623
Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Xaa 
1               5                   10                  15      


Xaa Cys Leu Ala Glu Phe Xaa Trp Tyr Arg Arg Tyr Gly His Gly Val 
            20                  25                  30          


Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe Glu Glu Gln Pro Ile 
        35                  40                  45              


Asn Xaa Ile Tyr Pro Glu Glu Ser Leu Glu Gly Lys Val Ser Leu Asn 
    50                  55                  60                  


Cys Arg Ala Arg Ala Ser Pro Phe Pro Val Tyr Lys Trp Arg Met Asn 
65                  70                  75                  80  


Asn Gly Asp Val Asp 
                85  


<210> 6624
<211> 90
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<400> 6624
Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Xaa 
1               5                   10                  15      


Xaa Cys Leu Ala Glu Phe Xaa Trp Tyr Arg Arg Tyr Gly His Gly Val 
            20                  25                  30          


Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe Glu Glu Gln Pro Ile 
        35                  40                  45              


Asn Xaa Ile Tyr Pro Glu Glu Ser Leu Glu Gly Lys Val Ser Leu Asn 
    50                  55                  60                  


Cys Arg Ala Arg Ala Ser Pro Phe Pro Val Tyr Lys Trp Arg Met Asn 
65                  70                  75                  80  


Asn Gly Asp Val Asp Leu Xaa Ser Asp Arg 
                85                  90  


<210> 6625
<211> 627
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<400> 6625
Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Xaa 
1               5                   10                  15      


Xaa Cys Leu Ala Glu Phe Xaa Trp Tyr Arg Arg Tyr Gly His Gly Val 
            20                  25                  30          


Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe Glu Glu Gln Pro Ile 
        35                  40                  45              


Asn Xaa Ile Tyr Pro Glu Glu Ser Leu Glu Gly Lys Val Ser Leu Asn 
    50                  55                  60                  


Cys Arg Ala Arg Ala Ser Pro Phe Pro Val Tyr Lys Trp Arg Met Asn 
65                  70                  75                  80  


Asn Gly Asp Val Asp Leu Xaa Ser Asp Arg Tyr Ser Met Val Gly Gly 
                85                  90                  95      


Asn Leu Val Ile Asn Asn Pro Asp Lys Gln Lys Asp Ala Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Leu Ala Ser Asn Asn Tyr Gly Met Val Arg Ser Xaa Glu Ala 
        115                 120                 125             


Xaa Leu Ser Phe Gly Tyr Leu Asp Pro Phe Pro Pro Glu Glu Arg Pro 
    130                 135                 140                 


Glu Val Arg Val Lys Glu Gly Lys Gly Met Val Leu Leu Cys Asp Pro 
145                 150                 155                 160 


Pro Tyr His Phe Pro Asp Asp Leu Ser Tyr Arg Trp Leu Leu Asn Glu 
                165                 170                 175     


Phe Pro Val Phe Ile Xaa Met Asp Lys Arg Arg Phe Val Ser Gln Xaa 
            180                 185                 190         


Asn Gly Asn Leu Tyr Ile Ala Asn Val Glu Ala Ser Asp Lys Gly Asn 
        195                 200                 205             


Tyr Ser Cys Phe Val Ser Ser Pro Ser Ile Xaa Lys Ser Val Phe Ser 
    210                 215                 220                 


Lys Phe Ile Pro Leu Ile Pro Ile Pro Glu Arg Xaa Xaa Lys Pro Tyr 
225                 230                 235                 240 


Pro Ala Asp Ile Val Val Gln Phe Lys Asp Val Tyr Ala Leu Met Gly 
                245                 250                 255     


Gln Asn Val Xaa Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Asp 
            260                 265                 270         


Ile Arg Trp Arg Lys Val Leu Glu Pro Met Pro Ser Xaa Ala Glu Ile 
        275                 280                 285             


Ser Xaa Ser Gly Ala Val Leu Lys Ile Phe Asn Ile Gln Leu Glu Asp 
    290                 295                 300                 


Glu Gly Ile Tyr Glu Cys Glu Ala Glu Asn Ile Arg Gly Lys Asp Lys 
305                 310                 315                 320 


His Gln Ala Arg Ile Tyr Val Gln Ala Phe Pro Glu Trp Val Glu His 
                325                 330                 335     


Ile Asn Asp Xaa Glu Val Asp Ile Gly Ser Asp Leu Tyr Trp Pro Cys 
            340                 345                 350         


Val Ala Xaa Gly Lys Pro Ile Pro Xaa Ile Arg Trp Leu Lys Asn Gly 
        355                 360                 365             


Tyr Ala Tyr His Lys Gly Glu Leu Arg Leu Tyr Asp Val Xaa Phe Glu 
    370                 375                 380                 


Asn Ala Gly Met Tyr Gln Cys Ile Ala Glu Asn Xaa Tyr Gly Ala Ile 
385                 390                 395                 400 


Tyr Ala Asn Ala Glu Leu Lys Ile Leu Ala Leu Ala Pro Xaa Phe Glu 
                405                 410                 415     


Met Asn Pro Met Lys Lys Lys Ile Leu Ala Ala Lys Gly Gly Arg Val 
            420                 425                 430         


Ile Ile Glu Cys Lys Pro Lys Ala Ala Pro Lys Pro Lys Phe Ser Trp 
        435                 440                 445             


Ser Lys Gly Xaa Glu Trp Leu Val Asn Ser Ser Arg Ile Leu Ile Trp 
    450                 455                 460                 


Glu Asp Gly Ser Leu Glu Ile Asn Asn Ile Xaa Arg Asn Asp Gly Gly 
465                 470                 475                 480 


Ile Tyr Xaa Cys Phe Ala Glu Asn Asn Arg Gly Lys Ala Asn Ser Xaa 
                485                 490                 495     


Gly Xaa Leu Val Ile Xaa Asp Pro Xaa Arg Ile Ile Leu Ala Pro Ile 
            500                 505                 510         


Asn Ala Asp Ile Xaa Val Gly Glu Asn Ala Xaa Met Gln Cys Ala Ala 
        515                 520                 525             


Ser Phe Asp Pro Ala Leu Asp Leu Xaa Phe Val Trp Ser Phe Asn Gly 
    530                 535                 540                 


Tyr Val Ile Asp Phe Asn Lys Glu Asn Ile His Tyr Gln Arg Asn Phe 
545                 550                 555                 560 


Met Leu Asp Ser Asn Gly Glu Leu Leu Ile Arg Asn Ala Gln Leu Lys 
                565                 570                 575     


His Ala Gly Arg Tyr Xaa Cys Xaa Ala Gln Xaa Ile Val Asp Asn Ser 
            580                 585                 590         


Ser Ala Ser Ala Asp Leu Val Val Arg Gly Lys Asn Arg Lys Gly Gly 
        595                 600                 605             


Glu Lys Asn Met Val Asp Ser Phe Leu Pro Val Cys Ala Ser Leu Pro 
    610                 615                 620                 


Pro Xaa Trp 
625         


<210> 6626
<211> 1018
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<400> 6626
Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Xaa 
1               5                   10                  15      


Xaa Cys Leu Ala Glu Phe Xaa Trp Tyr Arg Arg Tyr Gly His Gly Val 
            20                  25                  30          


Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe Glu Glu Gln Pro Ile 
        35                  40                  45              


Asn Xaa Ile Tyr Pro Glu Glu Ser Leu Glu Gly Lys Val Ser Leu Asn 
    50                  55                  60                  


Cys Arg Ala Arg Ala Ser Pro Phe Pro Val Tyr Lys Trp Arg Met Asn 
65                  70                  75                  80  


Asn Gly Asp Val Asp Leu Xaa Ser Asp Arg Tyr Ser Met Val Gly Gly 
                85                  90                  95      


Asn Leu Val Ile Asn Asn Pro Asp Lys Gln Lys Asp Ala Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Leu Ala Ser Asn Asn Tyr Gly Met Val Arg Ser Xaa Glu Ala 
        115                 120                 125             


Xaa Leu Ser Phe Gly Tyr Leu Asp Pro Phe Pro Pro Glu Glu Arg Pro 
    130                 135                 140                 


Glu Val Arg Val Lys Glu Gly Lys Gly Met Val Leu Leu Cys Asp Pro 
145                 150                 155                 160 


Pro Tyr His Phe Pro Asp Asp Leu Ser Tyr Arg Trp Leu Leu Asn Glu 
                165                 170                 175     


Phe Pro Val Phe Ile Xaa Met Asp Lys Arg Arg Phe Val Ser Gln Xaa 
            180                 185                 190         


Asn Gly Asn Leu Tyr Ile Ala Asn Val Glu Ala Ser Asp Lys Gly Asn 
        195                 200                 205             


Tyr Ser Cys Phe Val Ser Ser Pro Ser Ile Xaa Lys Ser Val Phe Ser 
    210                 215                 220                 


Lys Phe Ile Pro Leu Ile Pro Ile Pro Glu Arg Xaa Xaa Lys Pro Tyr 
225                 230                 235                 240 


Pro Ala Asp Ile Val Val Gln Phe Lys Asp Val Tyr Ala Leu Met Gly 
                245                 250                 255     


Gln Asn Val Xaa Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Asp 
            260                 265                 270         


Ile Arg Trp Arg Lys Val Leu Glu Pro Met Pro Ser Xaa Ala Glu Ile 
        275                 280                 285             


Ser Xaa Ser Gly Ala Val Leu Lys Ile Phe Asn Ile Gln Leu Glu Asp 
    290                 295                 300                 


Glu Gly Ile Tyr Glu Cys Glu Ala Glu Asn Ile Arg Gly Lys Asp Lys 
305                 310                 315                 320 


His Gln Ala Arg Ile Tyr Val Gln Ala Phe Pro Glu Trp Val Glu His 
                325                 330                 335     


Ile Asn Asp Xaa Glu Val Asp Ile Gly Ser Asp Leu Tyr Trp Pro Cys 
            340                 345                 350         


Val Ala Xaa Gly Lys Pro Ile Pro Xaa Ile Arg Trp Leu Lys Asn Gly 
        355                 360                 365             


Tyr Ala Tyr His Lys Gly Glu Leu Arg Leu Tyr Asp Val Xaa Phe Glu 
    370                 375                 380                 


Asn Ala Gly Met Tyr Gln Cys Ile Ala Glu Asn Xaa Tyr Gly Ala Ile 
385                 390                 395                 400 


Tyr Ala Asn Ala Glu Leu Lys Ile Leu Ala Leu Ala Pro Xaa Phe Glu 
                405                 410                 415     


Met Asn Pro Met Lys Lys Lys Ile Leu Ala Ala Lys Gly Gly Arg Val 
            420                 425                 430         


Ile Ile Glu Cys Lys Pro Lys Ala Ala Pro Lys Pro Lys Phe Ser Trp 
        435                 440                 445             


Ser Lys Gly Xaa Glu Trp Leu Val Asn Ser Ser Arg Ile Leu Ile Trp 
    450                 455                 460                 


Glu Asp Gly Ser Leu Glu Ile Asn Asn Ile Xaa Arg Asn Asp Gly Gly 
465                 470                 475                 480 


Ile Tyr Xaa Cys Phe Ala Glu Asn Asn Arg Gly Lys Ala Asn Ser Xaa 
                485                 490                 495     


Gly Xaa Leu Val Ile Xaa Asp Pro Xaa Arg Ile Ile Leu Ala Pro Ile 
            500                 505                 510         


Asn Ala Asp Ile Xaa Val Gly Glu Asn Ala Xaa Met Gln Cys Ala Ala 
        515                 520                 525             


Ser Phe Asp Pro Ala Leu Asp Leu Xaa Phe Val Trp Ser Phe Asn Gly 
    530                 535                 540                 


Tyr Val Ile Asp Phe Asn Lys Glu Asn Ile His Tyr Gln Arg Asn Phe 
545                 550                 555                 560 


Met Leu Asp Ser Asn Gly Glu Leu Leu Ile Arg Asn Ala Gln Leu Lys 
                565                 570                 575     


His Ala Gly Arg Tyr Xaa Cys Xaa Ala Gln Xaa Ile Val Asp Asn Ser 
            580                 585                 590         


Ser Ala Ser Ala Asp Leu Val Val Arg Gly Pro Pro Gly Pro Pro Gly 
        595                 600                 605             


Gly Leu Arg Ile Glu Asp Ile Arg Ala Xaa Ser Val Ala Leu Xaa Trp 
    610                 615                 620                 


Ser Arg Gly Ser Asp Asn His Ser Pro Ile Ser Lys Tyr Xaa Ile Gln 
625                 630                 635                 640 


Xaa Lys Xaa Ile Leu Ser Asp Asp Trp Lys Asp Ala Lys Xaa Asp Pro 
                645                 650                 655     


Pro Ile Ile Glu Gly Asn Met Glu Ala Ala Arg Ala Val Asp Leu Ile 
            660                 665                 670         


Pro Trp Met Glu Tyr Glu Phe Arg Val Val Ala Xaa Asn Xaa Leu Gly 
        675                 680                 685             


Arg Gly Glu Pro Ser Ile Pro Ser Asn Arg Ile Lys Xaa Asp Gly Ala 
    690                 695                 700                 


Ala Pro Asn Val Ala Pro Ser Asp Val Gly Gly Gly Gly Gly Arg Asn 
705                 710                 715                 720 


Arg Glu Leu Xaa Ile Xaa Trp Ala Pro Leu Ser Arg Glu Tyr His Tyr 
                725                 730                 735     


Gly Asn Asn Phe Gly Tyr Ile Val Ala Phe Lys Pro Phe Asp Gly Glu 
            740                 745                 750         


Glu Trp Lys Lys Val Xaa Val Xaa Asn Pro Asp Xaa Gly Arg Tyr Val 
        755                 760                 765             


His Lys Asp Glu Xaa Met Ser Pro Ser Xaa Ala Phe Gln Val Lys Val 
    770                 775                 780                 


Lys Ala Phe Asn Asn Lys Gly Asp Gly Pro Tyr Ser Leu Val Ala Val 
785                 790                 795                 800 


Ile Asn Ser Ala Gln Asp Ala Pro Ser Glu Ala Pro Xaa Glu Val Gly 
                805                 810                 815     


Val Lys Val Leu Ser Ser Ser Glu Ile Ser Val His Trp Glu His Val 
            820                 825                 830         


Leu Glu Lys Ile Val Glu Ser Tyr Gln Ile Arg Tyr Trp Ala Ala His 
        835                 840                 845             


Asp Lys Glu Glu Ala Ala Asn Arg Val Gln Val Xaa Ser Gln Glu Tyr 
    850                 855                 860                 


Ser Ala Arg Leu Glu Asn Leu Leu Pro Asp Xaa Gln Tyr Phe Ile Glu 
865                 870                 875                 880 


Val Gly Ala Cys Asn Ser Ala Gly Cys Gly Pro Pro Ser Asp Met Ile 
                885                 890                 895     


Glu Ala Phe Xaa Lys Lys Ala Pro Pro Ser Gln Pro Pro Arg Ile Ile 
            900                 905                 910         


Ser Ser Val Arg Ser Gly Ser Arg Tyr Ile Ile Xaa Trp Asp His Val 
        915                 920                 925             


Val Ala Leu Ser Asn Glu Ser Xaa Val Xaa Gly Tyr Lys Val Leu Tyr 
    930                 935                 940                 


Arg Pro Asp Gly Gln His Asp Gly Lys Leu Tyr Ser Xaa His Lys His 
945                 950                 955                 960 


Ser Ile Glu Val Pro Ile Pro Arg Asp Gly Glu Tyr Val Val Glu Val 
                965                 970                 975     


Arg Ala His Ser Asp Gly Gly Asp Gly Val Val Ser Gln Val Lys Ile 
            980                 985                 990         


Ser Gly Ala Pro Xaa Leu Ser Pro  Ser Leu Leu Gly Leu  Leu Leu Pro 
        995                 1000                 1005             


Ala Phe  Gly Ile Leu Val Tyr  Leu Glu Phe 
    1010                 1015             


<210> 6627
<211> 1007
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(986)
<223> Selenocysteine

<400> 6627
Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Xaa 
1               5                   10                  15      


Xaa Cys Leu Ala Val Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe 
            20                  25                  30          


Glu Glu Gln Pro Ile Asn Xaa Ile Tyr Pro Glu Glu Ser Leu Glu Gly 
        35                  40                  45              


Lys Val Ser Leu Asn Cys Arg Ala Arg Ala Ser Pro Phe Pro Val Tyr 
    50                  55                  60                  


Lys Trp Arg Met Asn Asn Gly Asp Val Asp Leu Xaa Ser Asp Arg Tyr 
65                  70                  75                  80  


Ser Met Val Gly Gly Asn Leu Val Ile Asn Asn Pro Asp Lys Gln Lys 
                85                  90                  95      


Asp Ala Gly Ile Tyr Tyr Cys Leu Ala Ser Asn Asn Tyr Gly Met Val 
            100                 105                 110         


Arg Ser Xaa Glu Ala Xaa Leu Ser Phe Gly Tyr Leu Asp Pro Phe Pro 
        115                 120                 125             


Pro Glu Glu Arg Pro Glu Val Arg Val Lys Glu Gly Lys Gly Met Val 
    130                 135                 140                 


Leu Leu Cys Asp Pro Pro Tyr His Phe Pro Asp Asp Leu Ser Tyr Arg 
145                 150                 155                 160 


Trp Leu Leu Asn Glu Phe Pro Val Phe Ile Xaa Met Asp Lys Arg Arg 
                165                 170                 175     


Phe Val Ser Gln Xaa Asn Gly Asn Leu Tyr Ile Ala Asn Val Glu Ala 
            180                 185                 190         


Ser Asp Lys Gly Asn Tyr Ser Cys Phe Val Ser Ser Pro Ser Ile Xaa 
        195                 200                 205             


Lys Ser Val Phe Ser Lys Phe Ile Pro Leu Ile Pro Ile Pro Glu Arg 
    210                 215                 220                 


Xaa Xaa Lys Pro Tyr Pro Ala Asp Ile Val Val Gln Phe Lys Asp Val 
225                 230                 235                 240 


Tyr Ala Leu Met Gly Gln Asn Val Xaa Leu Glu Cys Phe Ala Leu Gly 
                245                 250                 255     


Asn Pro Val Pro Asp Ile Arg Trp Arg Lys Val Leu Glu Pro Met Pro 
            260                 265                 270         


Ser Xaa Ala Glu Ile Ser Xaa Ser Gly Ala Val Leu Lys Ile Phe Asn 
        275                 280                 285             


Ile Gln Leu Glu Asp Glu Gly Ile Tyr Glu Cys Glu Ala Glu Asn Ile 
    290                 295                 300                 


Arg Gly Lys Asp Lys His Gln Ala Arg Ile Tyr Val Gln Ala Phe Pro 
305                 310                 315                 320 


Glu Trp Val Glu His Ile Asn Asp Xaa Glu Val Asp Ile Gly Ser Asp 
                325                 330                 335     


Leu Tyr Trp Pro Cys Val Ala Xaa Gly Lys Pro Ile Pro Xaa Ile Arg 
            340                 345                 350         


Trp Leu Lys Asn Gly Tyr Ala Tyr His Lys Gly Glu Leu Arg Leu Tyr 
        355                 360                 365             


Asp Val Xaa Phe Glu Asn Ala Gly Met Tyr Gln Cys Ile Ala Glu Asn 
    370                 375                 380                 


Xaa Tyr Gly Ala Ile Tyr Ala Asn Ala Glu Leu Lys Ile Leu Ala Leu 
385                 390                 395                 400 


Ala Pro Xaa Phe Glu Met Asn Pro Met Lys Lys Lys Ile Leu Ala Ala 
                405                 410                 415     


Lys Gly Gly Arg Val Ile Ile Glu Cys Lys Pro Lys Ala Ala Pro Lys 
            420                 425                 430         


Pro Lys Phe Ser Trp Ser Lys Gly Xaa Glu Trp Leu Val Asn Ser Ser 
        435                 440                 445             


Arg Ile Leu Ile Trp Glu Asp Gly Ser Leu Glu Ile Asn Asn Ile Xaa 
    450                 455                 460                 


Arg Asn Asp Gly Gly Ile Tyr Xaa Cys Phe Ala Glu Asn Asn Arg Gly 
465                 470                 475                 480 


Lys Ala Asn Ser Xaa Gly Xaa Leu Val Ile Xaa Asp Pro Xaa Arg Ile 
                485                 490                 495     


Ile Leu Ala Pro Ile Asn Ala Asp Ile Xaa Val Gly Glu Asn Ala Xaa 
            500                 505                 510         


Met Gln Cys Ala Ala Ser Phe Asp Pro Ala Leu Asp Leu Xaa Phe Val 
        515                 520                 525             


Trp Ser Phe Asn Gly Tyr Val Ile Asp Phe Asn Lys Glu Asn Ile His 
    530                 535                 540                 


Tyr Gln Arg Asn Phe Met Leu Asp Ser Asn Gly Glu Leu Leu Ile Arg 
545                 550                 555                 560 


Asn Ala Gln Leu Lys His Ala Gly Arg Tyr Xaa Cys Xaa Ala Gln Xaa 
                565                 570                 575     


Ile Val Asp Asn Ser Ser Ala Ser Ala Asp Leu Val Val Arg Gly Pro 
            580                 585                 590         


Pro Gly Pro Pro Gly Gly Leu Arg Ile Glu Asp Ile Arg Ala Xaa Ser 
        595                 600                 605             


Val Ala Leu Xaa Trp Ser Arg Gly Ser Asp Asn His Ser Pro Ile Ser 
    610                 615                 620                 


Lys Tyr Xaa Ile Gln Xaa Lys Xaa Ile Leu Ser Asp Asp Trp Lys Asp 
625                 630                 635                 640 


Ala Lys Xaa Asp Pro Pro Ile Ile Glu Gly Asn Met Glu Ala Ala Arg 
                645                 650                 655     


Ala Val Asp Leu Ile Pro Trp Met Glu Tyr Glu Phe Arg Val Val Ala 
            660                 665                 670         


Xaa Asn Xaa Leu Gly Arg Gly Glu Pro Ser Ile Pro Ser Asn Arg Ile 
        675                 680                 685             


Lys Xaa Asp Gly Ala Ala Pro Asn Val Ala Pro Ser Asp Val Gly Gly 
    690                 695                 700                 


Gly Gly Gly Arg Asn Arg Glu Leu Xaa Ile Xaa Trp Ala Pro Leu Ser 
705                 710                 715                 720 


Arg Glu Tyr His Tyr Gly Asn Asn Phe Gly Tyr Ile Val Ala Phe Lys 
                725                 730                 735     


Pro Phe Asp Gly Glu Glu Trp Lys Lys Val Xaa Val Xaa Asn Pro Asp 
            740                 745                 750         


Xaa Gly Arg Tyr Val His Lys Asp Glu Xaa Met Ser Pro Ser Xaa Ala 
        755                 760                 765             


Phe Gln Val Lys Val Lys Ala Phe Asn Asn Lys Gly Asp Gly Pro Tyr 
    770                 775                 780                 


Ser Leu Val Ala Val Ile Asn Ser Ala Gln Asp Ala Pro Ser Glu Ala 
785                 790                 795                 800 


Pro Xaa Glu Val Gly Val Lys Val Leu Ser Ser Ser Glu Ile Ser Val 
                805                 810                 815     


His Trp Glu His Val Leu Glu Lys Ile Val Glu Ser Tyr Gln Ile Arg 
            820                 825                 830         


Tyr Trp Ala Ala His Asp Lys Glu Glu Ala Ala Asn Arg Val Gln Val 
        835                 840                 845             


Xaa Ser Gln Glu Tyr Ser Ala Arg Leu Glu Asn Leu Leu Pro Asp Xaa 
    850                 855                 860                 


Gln Tyr Phe Ile Glu Val Gly Ala Cys Asn Ser Ala Gly Cys Gly Pro 
865                 870                 875                 880 


Pro Ser Asp Met Ile Glu Ala Phe Xaa Lys Lys Ala Pro Pro Ser Gln 
                885                 890                 895     


Pro Pro Arg Ile Ile Ser Ser Val Arg Ser Gly Ser Arg Tyr Ile Ile 
            900                 905                 910         


Xaa Trp Asp His Val Val Ala Leu Ser Asn Glu Ser Xaa Val Xaa Gly 
        915                 920                 925             


Tyr Lys Val Leu Tyr Arg Pro Asp Gly Gln His Asp Gly Lys Leu Tyr 
    930                 935                 940                 


Ser Xaa His Lys His Ser Ile Glu Val Pro Ile Pro Arg Asp Gly Glu 
945                 950                 955                 960 


Tyr Val Val Glu Val Arg Ala His Ser Asp Gly Gly Asp Gly Val Val 
                965                 970                 975     


Ser Gln Val Lys Ile Ser Gly Ala Pro Xaa Leu Ser Pro Ser Leu Leu 
            980                 985                 990         


Gly Leu Leu Leu Pro Ala Phe Gly  Ile Leu Val Tyr Leu  Glu Phe 
        995                 1000                 1005         


<210> 6628
<211> 1040
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (732)..(732)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (986)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<400> 6628
Met Gly Xaa Ala Xaa Arg Arg Lys Pro His Leu Leu Leu Val Ala Ala 
1               5                   10                  15      


Val Ala Leu Val Ser Ser Ser Ala Trp Ser Ser Ala Leu Gly Ser Gln 
            20                  25                  30          


Xaa Xaa Phe Gly Pro Val Phe Glu Asp Gln Pro Leu Ser Val Leu Phe 
        35                  40                  45              


Pro Glu Glu Ser Xaa Glu Glu Gln Val Leu Leu Ala Cys Arg Ala Arg 
    50                  55                  60                  


Ala Ser Pro Pro Ala Xaa Tyr Arg Trp Lys Met Asn Gly Xaa Glu Met 
65                  70                  75                  80  


Lys Leu Glu Pro Gly Ser Arg His Gln Leu Val Gly Gly Asn Leu Val 
                85                  90                  95      


Ile Met Asn Pro Xaa Lys Ala Gln Asp Ala Gly Val Tyr Gln Cys Leu 
            100                 105                 110         


Ala Ser Asn Pro Val Gly Xaa Val Val Ser Arg Glu Ala Ile Leu Arg 
        115                 120                 125             


Phe Gly Phe Leu Gln Glu Phe Ser Lys Glu Glu Arg Asp Pro Val Lys 
    130                 135                 140                 


Ala His Glu Gly Trp Gly Val Met Leu Pro Cys Asn Pro Pro Ala His 
145                 150                 155                 160 


Tyr Pro Gly Leu Ser Tyr Arg Trp Leu Leu Asn Glu Phe Pro Asn Phe 
                165                 170                 175     


Ile Pro Xaa Asp Gly Arg His Phe Val Ser Gln Xaa Xaa Gly Asn Leu 
            180                 185                 190         


Tyr Ile Ala Arg Xaa Asn Ala Ser Asp Leu Gly Asn Tyr Ser Cys Leu 
        195                 200                 205             


Ala Xaa Ser His Met Asp Phe Ser Xaa Lys Ser Val Phe Ser Lys Phe 
    210                 215                 220                 


Ala Gln Leu Asn Leu Ala Ala Glu Asp Xaa Arg Leu Phe Ala Pro Ser 
225                 230                 235                 240 


Ile Lys Ala Arg Phe Pro Ala Glu Xaa Tyr Ala Leu Val Gly Gln Gln 
                245                 250                 255     


Val Xaa Leu Glu Cys Phe Ala Phe Gly Asn Pro Val Pro Arg Ile Lys 
            260                 265                 270         


Trp Arg Lys Val Asp Gly Ser Leu Ser Pro Gln Trp Xaa Xaa Ala Glu 
        275                 280                 285             


Pro Xaa Leu Gln Ile Pro Ser Val Ser Phe Glu Asp Glu Gly Xaa Tyr 
    290                 295                 300                 


Glu Cys Glu Ala Glu Asn Ser Lys Gly Arg Asp Xaa Val Gln Gly Arg 
305                 310                 315                 320 


Ile Ile Val Gln Ala Gln Pro Glu Trp Leu Lys Val Ile Ser Asp Xaa 
                325                 330                 335     


Glu Ala Asp Ile Gly Ser Asn Leu Arg Trp Gly Cys Ala Ala Ala Gly 
            340                 345                 350         


Lys Pro Arg Pro Xaa Val Arg Trp Leu Arg Asn Gly Glu Pro Leu Ala 
        355                 360                 365             


Ser Gln Asn Arg Val Glu Val Leu Ala Gly Asp Leu Arg Phe Ser Lys 
    370                 375                 380                 


Leu Ser Leu Glu Asp Ser Gly Met Tyr Gln Cys Val Ala Glu Asn Lys 
385                 390                 395                 400 


His Gly Xaa Ile Tyr Ala Ser Ala Glu Leu Ala Val Gln Ala Leu Ala 
                405                 410                 415     


Pro Asp Phe Arg Leu Asn Pro Val Arg Arg Leu Ile Pro Ala Ala Arg 
            420                 425                 430         


Gly Gly Glu Ile Leu Ile Pro Cys Gln Pro Arg Ala Ala Pro Lys Ala 
        435                 440                 445             


Val Val Leu Trp Ser Lys Gly Xaa Glu Ile Leu Val Asn Ser Ser Arg 
    450                 455                 460                 


Val Xaa Val Xaa Pro Asp Gly Xaa Leu Ile Ile Arg Asn Ile Ser Arg 
465                 470                 475                 480 


Ser Asp Glu Gly Lys Tyr Xaa Cys Phe Ala Glu Asn Phe Met Gly Lys 
                485                 490                 495     


Ala Asn Ser Xaa Gly Ile Leu Ser Val Arg Asp Ala Xaa Lys Ile Xaa 
            500                 505                 510         


Leu Ala Pro Ser Ser Ala Asp Ile Asn Leu Gly Asp Asn Leu Xaa Leu 
        515                 520                 525             


Gln Cys His Ala Ser His Asp Pro Xaa Met Asp Leu Xaa Phe Xaa Trp 
    530                 535                 540                 


Xaa Leu Asp Asp Phe Pro Ile Asp Phe Asp Lys Pro Gly Gly His Tyr 
545                 550                 555                 560 


Arg Arg Xaa Asn Val Lys Glu Xaa Ile Gly Asp Leu Xaa Ile Leu Asn 
                565                 570                 575     


Ala Gln Leu Arg His Gly Gly Lys Tyr Xaa Cys Met Ala Gln Xaa Val 
            580                 585                 590         


Val Asp Ser Ala Ser Lys Glu Ala Xaa Val Leu Val Arg Gly Pro Pro 
        595                 600                 605             


Gly Pro Pro Gly Gly Val Val Val Arg Asp Ile Gly Asp Xaa Xaa Ile 
    610                 615                 620                 


Gln Leu Ser Trp Ser Arg Gly Phe Asp Asn His Ser Pro Ile Ala Lys 
625                 630                 635                 640 


Tyr Xaa Leu Gln Ala Arg Xaa Pro Pro Ala Gly Lys Trp Lys Gln Val 
                645                 650                 655     


Arg Xaa Asn Pro Ala Asn Ile Glu Gly Asn Ala Glu Xaa Ala Gln Val 
            660                 665                 670         


Leu Gly Leu Xaa Pro Trp Met Asp Tyr Glu Phe Arg Val Ile Ala Ser 
        675                 680                 685             


Asn Ile Leu Gly Xaa Gly Glu Pro Ser Gly Pro Ser Ser Lys Ile Arg 
    690                 695                 700                 


Xaa Arg Glu Ala Ala Pro Ser Val Ala Pro Ser Gly Leu Ser Gly Gly 
705                 710                 715                 720 


Gly Gly Ala Pro Gly Glu Leu Ile Val Asn Trp Xaa Pro Met Ser Arg 
                725                 730                 735     


Glu Tyr Gln Asn Gly Asp Gly Phe Gly Tyr Leu Leu Ser Phe Arg Arg 
            740                 745                 750         


Gln Gly Ser Xaa His Trp Gln Xaa Ala Arg Val Pro Gly Ala Asp Ala 
        755                 760                 765             


Gln Tyr Phe Val Tyr Ser Asn Glu Ser Val Arg Pro Tyr Xaa Pro Phe 
    770                 775                 780                 


Glu Val Lys Ile Arg Ser Tyr Asn Arg Arg Gly Asp Gly Pro Glu Ser 
785                 790                 795                 800 


Leu Xaa Ala Leu Val Tyr Ser Ala Glu Glu Glu Pro Arg Val Ala Pro 
                805                 810                 815     


Xaa Lys Val Trp Ala Lys Gly Val Ser Ser Ser Glu Met Asn Val Xaa 
            820                 825                 830         


Trp Glu Pro Val Gln Gln Asp Met Asn Gly Ile Leu Leu Gly Tyr Glu 
        835                 840                 845             


Ile Arg Tyr Trp Lys Ala Gly Asp Lys Glu Ala Ala Ala Asp Arg Val 
    850                 855                 860                 


Arg Xaa Ala Gly Leu Asp Xaa Ser Ala Arg Val Ser Gly Leu His Pro 
865                 870                 875                 880 


Asn Xaa Lys Tyr His Val Xaa Val Arg Ala Tyr Asn Arg Ala Gly Xaa 
                885                 890                 895     


Gly Pro Ala Ser Pro Ser Ala Asn Ala Xaa Xaa Met Lys Pro Pro Pro 
            900                 905                 910         


Arg Arg Pro Pro Gly Asn Ile Ser Trp Xaa Phe Ser Ser Ser Ser Leu 
        915                 920                 925             


Ser Ile Lys Trp Asp Pro Val Val Pro Phe Arg Asn Glu Ser Ala Val 
    930                 935                 940                 


Xaa Gly Tyr Lys Met Leu Tyr Gln Asn Asp Leu His Leu Xaa Pro Xaa 
945                 950                 955                 960 


Leu His Leu Xaa Gly Lys Asn Trp Ile Glu Ile Pro Val Pro Glu Asp 
                965                 970                 975     


Ile Gly His Ala Leu Val Gln Ile Arg Xaa Xaa Gly Pro Gly Gly Asp 
            980                 985                 990         


Gly Ile Pro Ala Glu Val His Ile  Val Arg Asn Gly Gly  Xaa Ser Met 
        995                 1000                 1005             


Met Val  Glu Asn Met Ala Val  Arg Pro Ala Pro His  Pro Gly Xaa 
    1010                 1015                 1020             


Val Ile  Ser His Ser Val Ala  Met Leu Ile Leu Ile  Gly Ser Leu 
    1025                 1030                 1035             


Glu Leu  
    1040 


<210> 6629
<211> 46
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<400> 6629
Ser Gly Pro Ser Ser Lys Ile Arg Xaa Arg Glu Ala Ala Pro Ser Val 
1               5                   10                  15      


Ala Pro Ser Gly Leu Ser Gly Gly Gly Gly Ala Pro Gly Glu Leu Ile 
            20                  25                  30          


Val Asn Trp Xaa Gln Arg Glu Arg Pro Ala Leu His Ala Leu 
        35                  40                  45      


<210> 6630
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<400> 6630
Xaa Lys Glu Xaa Ile Gly Asp Leu Xaa Ile Leu Asn Ala Gln Leu Arg 
1               5                   10                  15      


His Gly Gly Lys Tyr Xaa Cys Met Ala Gln Xaa Val Val Asp Ser Ala 
            20                  25                  30          


Ser Lys Glu Ala Xaa Val Leu Val Arg Gly Pro Pro Gly Pro Pro Gly 
        35                  40                  45              


Gly Val Val Val Arg Asp Ile Gly Asp Xaa Xaa Ile Gln Leu Ser Trp 
    50                  55                  60                  


Ser Arg Gly Phe Asp Asn His Ser Pro Ile Ala Lys Tyr Xaa Leu Gln 
65                  70                  75                  80  


Ala Arg Xaa Pro Pro Ala Gly Lys Trp Lys Gln Val Arg Xaa Asn Pro 
                85                  90                  95      


Ala Asn Ile Glu Gly Asn Ala Glu Xaa Ala Gln Val Leu Gly Leu Xaa 
            100                 105                 110         


Pro Trp Met Asp Tyr Glu Phe Arg Val Ile Ala Ser Asn Ile Leu Gly 
        115                 120                 125             


Xaa Gly Glu Pro Ser Gly Pro Ser Ser Lys Ile Arg Xaa Arg Glu Ala 
    130                 135                 140                 


Ala Pro Ser Val Ala Pro Ser Gly Leu Ser Gly Gly Gly Gly Ala Pro 
145                 150                 155                 160 


Gly Glu Leu Ile Val Asn Trp Xaa Ala Gly Gln His Ser Leu Ala Asp 
                165                 170                 175     


Arg Pro Gly Ala Trp Arg Arg Cys Pro Val Leu Cys 
            180                 185             


<210> 6631
<211> 23
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<400> 6631
Xaa Pro His Pro Gly Xaa Val Ile Ser His Ser Val Ala Met Leu Ile 
1               5                   10                  15      


Leu Ile Gly Ser Leu Glu Leu 
            20              


<210> 6632
<211> 63
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 6632
Met Ala Leu Glu Trp Gln Leu Leu Ser Ala Leu Ser Asp Ser Val Lys 
1               5                   10                  15      


Val Asp Glu Asp Arg Ala Gly Phe Gln Cys Arg Lys Asn Phe Pro Phe 
            20                  25                  30          


Glu Tyr Ser Lys Arg Glu Leu Cys Xaa Cys Ala Ser Arg Xaa Asp Cys 
        35                  40                  45              


Leu Ala Pro Xaa Gly Met Gln Gln Glu Arg Ser Val Phe His Ala 
    50                  55                  60              


<210> 6633
<211> 41
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<400> 6633
Met Glu Xaa Gly Asn Ser Ala Ala Xaa His Lys Leu Phe Cys Arg Lys 
1               5                   10                  15      


Val Tyr Ile Ser Pro Ile Leu Leu Leu Xaa Gly Leu Arg Leu Trp Leu 
            20                  25                  30          


Leu His Leu Glu Ile Tyr Leu Leu Cys 
        35                  40      


<210> 6634
<211> 1028
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (873)..(873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<400> 6634
Met Arg Leu Leu Trp Lys Leu Val Ile Leu Leu Pro Leu Ile Asn Ser 
1               5                   10                  15      


Ser Ala Gly Asp Gly Leu Leu Ser Arg Pro Ile Phe Xaa Gln Glu Pro 
            20                  25                  30          


His Asp Val Ile Phe Pro Leu Asp Leu Ser Lys Ser Glu Val Ile Leu 
        35                  40                  45              


Asn Cys Ala Ala Asn Gly Tyr Pro Ser Pro His Tyr Arg Trp Lys Gln 
    50                  55                  60                  


Asn Gly Xaa Asp Ile Asp Phe Xaa Met Ser Tyr His Tyr Arg Leu Asp 
65                  70                  75                  80  


Gly Gly Ser Leu Ala Ile Asn Ser Pro His Xaa Asp Gln Asp Ile Gly 
                85                  90                  95      


Met Tyr Gln Cys Leu Ala Xaa Asn Leu Leu Gly Xaa Ile Leu Ser Arg 
            100                 105                 110         


Lys Ala Lys Leu Gln Phe Ala Tyr Ile Glu Asp Phe Glu Xaa Lys Xaa 
        115                 120                 125             


Arg Ser Xaa Val Ser Val Arg Glu Gly Gln Gly Val Val Leu Leu Cys 
    130                 135                 140                 


Gly Pro Pro Pro His Phe Gly Asp Leu Ser Tyr Ala Trp Xaa Phe Asn 
145                 150                 155                 160 


Asp Asn Pro Leu Tyr Val Gln Glu Asp Asn Arg Arg Phe Val Ser Gln 
                165                 170                 175     


Glu Xaa Gly Asn Leu Tyr Ile Ala Lys Val Glu Pro Ser Asp Val Gly 
            180                 185                 190         


Asn Tyr Xaa Cys Phe Ile Xaa Asn Lys Glu Ala Gln Arg Ser Val Gln 
        195                 200                 205             


Gly Pro Pro Xaa Pro Leu Val Gln Arg Xaa Asp Gly Val Met Gly Glu 
    210                 215                 220                 


Tyr Glu Pro Lys Ile Glu Val Arg Phe Pro Glu Xaa Ile Gln Ala Ala 
225                 230                 235                 240 


Lys Asp Ser Ser Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Val 
                245                 250                 255     


Pro Asp Ile Ser Trp Arg Arg Leu Asp Gly Ser Pro Leu Pro Gly Lys 
            260                 265                 270         


Val Lys Tyr Ser Lys Ser Gln Ala Ile Leu Glu Ile Pro Asn Phe Gln 
        275                 280                 285             


Gln Glu Asp Glu Gly Phe Tyr Glu Cys Ile Ala Ser Asn Leu Arg Gly 
    290                 295                 300                 


Arg Asn Leu Ala Lys Gly Gln Leu Ile Phe Tyr Ala Pro Pro Glu Trp 
305                 310                 315                 320 


Glu Gln Lys Ile Gln Asn Xaa His Leu Ser Ile Tyr Asp Asn Leu Leu 
                325                 330                 335     


Trp Glu Cys Lys Ala Ser Gly Lys Pro Asn Pro Trp Tyr Xaa Trp Leu 
            340                 345                 350         


Lys Asn Gly Glu Arg Leu Asn Pro Glu Glu Arg Ile Gln Ile Glu Asn 
        355                 360                 365             


Gly Xaa Leu Ile Ile Xaa Met Leu Asn Val Ser Asp Ser Gly Val Tyr 
    370                 375                 380                 


Gln Cys Ala Ala Glu Asn Lys Tyr Gln Ile Ile Tyr Ala Asn Ala Glu 
385                 390                 395                 400 


Leu Arg Val Leu Ala Ser Ala Pro Asp Phe Ser Lys Ser Pro Val Lys 
                405                 410                 415     


Lys Lys Ser Phe Val Gln Val Gly Gly Asp Ile Val Ile Gly Cys Lys 
            420                 425                 430         


Pro Asn Ala Phe Pro Arg Ala Ala Ile Ser Trp Lys Arg Gly Xaa Glu 
        435                 440                 445             


Xaa Leu Arg Gln Ser Lys Arg Ile Phe Leu Leu Glu Asp Gly Ser Leu 
    450                 455                 460                 


Lys Ile Tyr Asn Ile Xaa Arg Ser Asp Ala Gly Ser Tyr Xaa Cys Ile 
465                 470                 475                 480 


Ala Xaa Asn Gln Phe Gly Xaa Ala Lys Asn Xaa Gly Ser Leu Ile Val 
                485                 490                 495     


Lys Glu Arg Xaa Val Ile Xaa Val Pro Pro Ser Lys Met Asp Val Xaa 
            500                 505                 510         


Val Gly Glu Ser Ile Val Leu Pro Cys Gln Val Ser His Asp Pro Ser 
        515                 520                 525             


Ile Glu Val Val Phe Val Trp Phe Phe Asn Gly Asp Val Ile Asp Leu 
    530                 535                 540                 


Lys Lys Gly Val Ala His Phe Glu Arg Ile Gly Gly Glu Ser Val Gly 
545                 550                 555                 560 


Asp Leu Met Ile Arg Asn Ile Gln Leu His His Ser Gly Lys Tyr Leu 
                565                 570                 575     


Cys Xaa Val Gln Xaa Xaa Leu Glu Ser Leu Ser Ala Val Ala Asp Ile 
            580                 585                 590         


Ile Val Arg Gly Pro Pro Gly Pro Pro Glu Asp Val Gln Val Glu Asp 
        595                 600                 605             


Ile Ser Ser Xaa Xaa Ser Gln Leu Ser Trp Arg Ala Gly Pro Asp Asn 
    610                 615                 620                 


Asn Ser Pro Ile Gln Ile Phe Xaa Ile Gln Xaa Arg Xaa Pro Phe Ser 
625                 630                 635                 640 


Val Gly Trp Gln Ala Val Ala Xaa Val Pro Glu Ile Leu Asn Gly Lys 
                645                 650                 655     


Xaa Tyr Asn Ala Xaa Val Val Gly Leu Ser Pro Trp Val Glu Tyr Glu 
            660                 665                 670         


Phe Arg Val Val Ala Gly Asn Ser Ile Gly Ile Gly Glu Pro Ser Glu 
        675                 680                 685             


Pro Ser Glu Leu Leu Arg Xaa Lys Ala Ser Val Pro Val Val Ala Pro 
    690                 695                 700                 


Val Asn Ile His Gly Gly Gly Gly Ser Arg Ser Glu Leu Val Ile Xaa 
705                 710                 715                 720 


Trp Glu Ser Ile Pro Glu Glu Leu Gln Asn Gly Glu Gly Phe Gly Tyr 
                725                 730                 735     


Ile Ile Met Phe Arg Pro Val Gly Ser Xaa Xaa Trp Ser Lys Glu Lys 
            740                 745                 750         


Val Ser Ser Val Glu Ser Ser Arg Phe Val Tyr Arg Asn Glu Ser Ile 
        755                 760                 765             


Ile Pro Leu Ser Pro Phe Glu Val Lys Val Gly Val Tyr Asn Asn Glu 
    770                 775                 780                 


Gly Glu Gly Ser Leu Ser Xaa Val Xaa Ile Val Tyr Ser Gly Glu Asp 
785                 790                 795                 800 


Glu Pro Gln Leu Ala Pro Arg Gly Xaa Ser Leu Gln Ser Phe Ser Ala 
                805                 810                 815     


Ser Glu Met Glu Val Ser Trp Asn Ala Ile Ala Trp Asn Arg Asn Xaa 
            820                 825                 830         


Gly Arg Val Leu Gly Tyr Glu Val Leu Tyr Trp Xaa Asp Asp Ser Lys 
        835                 840                 845             


Glu Ser Met Ile Gly Lys Ile Arg Val Ser Gly Asn Val Xaa Xaa Lys 
    850                 855                 860                 


Asn Ile Xaa Gly Leu Lys Ala Asn Xaa Ile Tyr Phe Ala Ser Val Arg 
865                 870                 875                 880 


Ala Tyr Asn Xaa Ala Gly Xaa Gly Pro Ser Ser Pro Pro Val Asn Val 
                885                 890                 895     


Xaa Xaa Lys Lys Ser Pro Pro Ser Gln Pro Pro Ala Asn Ile Ala Trp 
            900                 905                 910         


Lys Leu Xaa Asn Ser Lys Leu Cys Leu Asn Trp Glu His Val Lys Xaa 
        915                 920                 925             


Met Glu Asn Glu Ser Glu Val Leu Gly Tyr Lys Ile Leu Tyr Arg Gln 
    930                 935                 940                 


Asn Arg Gln Ser Lys Xaa His Ile Leu Glu Xaa Asn Asn Xaa Ser Ala 
945                 950                 955                 960 


Glu Leu Leu Val Pro Phe Glu Glu Asp Tyr Leu Ile Glu Ile Arg Xaa 
                965                 970                 975     


Val Ser Asp Gly Gly Asp Gly Ser Ser Ser Glu Glu Ile Arg Ile Pro 
            980                 985                 990         


Lys Met Ser Ser Leu Ser Ser Arg  Gly Ile Gln Phe Leu  Glu Pro Ser 
        995                 1000                 1005             


Xaa His  Phe Leu Ser Ile Val  Ile Val Ile Phe His  Cys Phe Ala 
    1010                 1015                 1020             


Ile Gln  Pro Leu Ile 
    1025             


<210> 6635
<211> 740
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<400> 6635
Met Met His Leu Arg Leu Phe Cys Ile Leu Leu Ala Ala Val Ser Gly 
1               5                   10                  15      


Ala Glu Gly Trp Gly Tyr Tyr Gly Cys Asp Glu Glu Leu Val Gly Pro 
            20                  25                  30          


Leu Tyr Ala Arg Ser Leu Gly Ala Ser Ser Tyr Tyr Ser Leu Leu Xaa 
        35                  40                  45              


Ala Pro Arg Phe Ala Arg Leu His Gly Ile Ser Gly Trp Ser Pro Arg 
    50                  55                  60                  


Ile Gly Asp Pro Asn Pro Trp Leu Gln Ile Asp Leu Met Lys Lys His 
65                  70                  75                  80  


Arg Ile Arg Ala Val Ala Xaa Gln Gly Ser Phe Asn Ser Trp Asp Trp 
                85                  90                  95      


Val Xaa Arg Tyr Met Leu Leu Tyr Gly Asp Arg Val Asp Ser Trp Xaa 
            100                 105                 110         


Pro Phe Tyr Gln Arg Gly His Asn Ser Xaa Phe Phe Gly Asn Val Asn 
        115                 120                 125             


Glu Ser Ala Val Val Arg His Asp Leu His Phe His Phe Xaa Ala Arg 
    130                 135                 140                 


Tyr Ile Arg Ile Val Pro Leu Ala Trp Asn Pro Arg Gly Lys Ile Gly 
145                 150                 155                 160 


Leu Arg Leu Gly Leu Tyr Gly Cys Pro Tyr Lys Ala Asp Ile Leu Tyr 
                165                 170                 175     


Phe Asp Gly Asp Asp Ala Ile Ser Tyr Arg Phe Pro Arg Gly Val Ser 
            180                 185                 190         


Arg Ser Leu Trp Asp Val Phe Ala Phe Ser Phe Lys Xaa Glu Glu Lys 
        195                 200                 205             


Asp Gly Leu Leu Leu His Ala Glu Gly Ala Gln Gly Asp Tyr Val Xaa 
    210                 215                 220                 


Leu Glu Leu Glu Gly Ala His Leu Leu Leu His Met Ser Leu Gly Ser 
225                 230                 235                 240 


Ser Pro Ile Gln Pro Arg Pro Gly His Xaa Xaa Val Ser Ala Gly Gly 
                245                 250                 255     


Val Leu Asn Asp Gln His Trp His Tyr Val Arg Val Asp Arg Phe Gly 
            260                 265                 270         


Arg Asp Val Asn Phe Xaa Leu Asp Gly Tyr Val Gln Arg Phe Ile Leu 
        275                 280                 285             


Asn Gly Asp Phe Glu Arg Leu Asn Leu Asp Xaa Glu Met Phe Ile Gly 
    290                 295                 300                 


Gly Leu Val Gly Ala Ala Arg Lys Asn Leu Ala Tyr Arg His Asn Phe 
305                 310                 315                 320 


Arg Gly Cys Ile Glu Asn Val Ile Phe Asn Arg Val Asn Ile Ala Asp 
                325                 330                 335     


Leu Ala Val Arg Arg His Ser Arg Ile Xaa Phe Glu Gly Lys Val Ala 
            340                 345                 350         


Phe Arg Cys Leu Asp Pro Val Pro His Pro Ile Asn Phe Gly Gly Pro 
        355                 360                 365             


His Asn Phe Val Gln Val Pro Gly Phe Pro Arg Arg Gly Arg Leu Ala 
    370                 375                 380                 


Val Ser Phe Arg Phe Arg Xaa Trp Asp Leu Xaa Gly Leu Leu Leu Phe 
385                 390                 395                 400 


Ser Arg Leu Gly Asp Gly Leu Gly His Val Glu Leu Xaa Leu Ser Glu 
                405                 410                 415     


Gly Gln Val Asn Val Ser Ile Ala Gln Ser Gly Arg Lys Lys Leu Gln 
            420                 425                 430         


Phe Ala Ala Gly Tyr Arg Leu Asn Asp Gly Phe Trp His Glu Val Asn 
        435                 440                 445             


Phe Val Ala Gln Glu Asn His Ala Val Ile Ser Ile Asp Asp Val Glu 
    450                 455                 460                 


Gly Ala Glu Val Arg Val Ser Tyr Pro Leu Leu Ile Arg Xaa Gly Xaa 
465                 470                 475                 480 


Ser Tyr Phe Phe Gly Gly Cys Pro Lys Pro Ala Ser Arg Trp Asp Cys 
                485                 490                 495     


His Ser Asn Gln Xaa Ala Phe His Gly Cys Met Glu Leu Leu Lys Val 
            500                 505                 510         


Asp Gly Gln Leu Val Asn Leu Xaa Leu Val Glu Gly Arg Arg Leu Gly 
        515                 520                 525             


Phe Tyr Ala Glu Val Leu Phe Asp Xaa Cys Gly Ile Xaa Asp Arg Cys 
    530                 535                 540                 


Ser Pro Asn Met Cys Glu His Asp Gly Arg Cys Tyr Gln Ser Trp Asp 
545                 550                 555                 560 


Asp Phe Ile Cys Tyr Cys Glu Leu Xaa Gly Tyr Lys Gly Glu Xaa Cys 
                565                 570                 575     


His Xaa Pro Leu Tyr Lys Glu Ser Cys Glu Ala Tyr Arg Leu Ser Gly 
            580                 585                 590         


Lys Xaa Ser Gly Asn Phe Xaa Ile Asp Pro Asp Gly Ser Gly Pro Leu 
        595                 600                 605             


Lys Pro Phe Val Val Tyr Cys Asp Ile Arg Glu Asn Arg Ala Trp Xaa 
    610                 615                 620                 


Val Val Arg His Asp Arg Leu Trp Xaa Xaa Arg Val Xaa Gly Ser Ser 
625                 630                 635                 640 


Met Glu Arg Pro Phe Leu Gly Ala Ile Gln Tyr Trp Asn Ala Ser Trp 
                645                 650                 655     


Glu Glu Val Ser Ala Leu Ala Asn Ala Ser Gln His Cys Glu Gln Trp 
            660                 665                 670         


Ile Glu Phe Ser Cys Tyr Asn Ser Arg Leu Leu Asn Xaa Ala Ala Phe 
        675                 680                 685             


Gly Leu Ala Glu Met Arg Ser Ser Xaa Ser Xaa Gly Glu Ala Pro Ser 
    690                 695                 700                 


Leu Gly Ser Ser Ala Val Pro Val Val Trp Xaa Gly Ala Val Trp Xaa 
705                 710                 715                 720 


Leu Pro Cys Xaa Ala Xaa Val Xaa Leu Xaa Ser Pro Ser Gly Glu Leu 
                725                 730                 735     


Xaa Arg Asp Cys 
            740 


<210> 6636
<211> 1384
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1007)..(1007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1045)..(1045)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1117)..(1117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1134)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1165)..(1165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1191)..(1191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1227)..(1227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1317)..(1317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1344)..(1344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1346)..(1346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1362)..(1362)
<223> Selenocysteine

<400> 6636
Met Met His Leu Arg Leu Phe Cys Ile Leu Leu Ala Ala Val Ser Gly 
1               5                   10                  15      


Ala Glu Gly Trp Gly Tyr Tyr Gly Cys Asp Glu Glu Leu Val Gly Pro 
            20                  25                  30          


Leu Tyr Ala Arg Ser Leu Gly Ala Ser Ser Tyr Tyr Ser Leu Leu Xaa 
        35                  40                  45              


Ala Pro Arg Phe Ala Arg Leu His Gly Ile Ser Gly Trp Ser Pro Arg 
    50                  55                  60                  


Ile Gly Asp Pro Asn Pro Trp Leu Gln Ile Asp Leu Met Lys Lys His 
65                  70                  75                  80  


Arg Ile Arg Ala Val Ala Xaa Gln Gly Ser Phe Asn Ser Trp Asp Trp 
                85                  90                  95      


Val Xaa Arg Tyr Met Leu Leu Tyr Gly Asp Arg Val Asp Ser Trp Xaa 
            100                 105                 110         


Pro Phe Tyr Gln Arg Gly His Asn Ser Xaa Phe Phe Gly Asn Val Asn 
        115                 120                 125             


Glu Ser Ala Val Val Arg His Asp Leu His Phe His Phe Xaa Ala Arg 
    130                 135                 140                 


Tyr Ile Arg Ile Val Pro Leu Ala Trp Asn Pro Arg Gly Lys Ile Gly 
145                 150                 155                 160 


Leu Arg Leu Gly Leu Tyr Gly Cys Pro Tyr Lys Ala Asp Ile Leu Tyr 
                165                 170                 175     


Phe Asp Gly Asp Asp Ala Ile Ser Tyr Arg Phe Pro Arg Gly Val Ser 
            180                 185                 190         


Arg Ser Leu Trp Asp Val Phe Ala Phe Ser Phe Lys Xaa Glu Glu Lys 
        195                 200                 205             


Asp Gly Leu Leu Leu His Ala Glu Gly Ala Gln Gly Asp Tyr Val Xaa 
    210                 215                 220                 


Leu Glu Leu Glu Gly Ala His Leu Leu Leu His Met Ser Leu Gly Ser 
225                 230                 235                 240 


Ser Pro Ile Gln Pro Arg Pro Gly His Xaa Xaa Val Ser Ala Gly Gly 
                245                 250                 255     


Val Leu Asn Asp Gln His Trp His Tyr Val Arg Val Asp Arg Phe Gly 
            260                 265                 270         


Arg Asp Val Asn Phe Xaa Leu Asp Gly Tyr Val Gln Arg Phe Ile Leu 
        275                 280                 285             


Asn Gly Asp Phe Glu Arg Leu Asn Leu Asp Xaa Glu Met Phe Ile Gly 
    290                 295                 300                 


Gly Leu Val Gly Ala Ala Arg Lys Asn Leu Ala Tyr Arg His Asn Phe 
305                 310                 315                 320 


Arg Gly Cys Ile Glu Asn Val Ile Phe Asn Arg Val Asn Ile Ala Asp 
                325                 330                 335     


Leu Ala Val Arg Arg His Ser Arg Ile Xaa Phe Glu Gly Lys Val Ala 
            340                 345                 350         


Phe Arg Cys Leu Asp Pro Val Pro His Pro Ile Asn Phe Gly Gly Pro 
        355                 360                 365             


His Asn Phe Val Gln Val Pro Gly Phe Pro Arg Arg Gly Arg Leu Ala 
    370                 375                 380                 


Val Ser Phe Arg Phe Arg Xaa Trp Asp Leu Xaa Gly Leu Leu Leu Phe 
385                 390                 395                 400 


Ser Arg Leu Gly Asp Gly Leu Gly His Val Glu Leu Xaa Leu Ser Glu 
                405                 410                 415     


Gly Gln Val Asn Val Ser Ile Ala Gln Ser Gly Arg Lys Lys Leu Gln 
            420                 425                 430         


Phe Ala Ala Gly Tyr Arg Leu Asn Asp Gly Phe Trp His Glu Val Asn 
        435                 440                 445             


Phe Val Ala Gln Glu Asn His Ala Val Ile Ser Ile Asp Asp Val Glu 
    450                 455                 460                 


Gly Ala Glu Val Arg Val Ser Tyr Pro Leu Leu Ile Arg Xaa Gly Xaa 
465                 470                 475                 480 


Ser Tyr Phe Phe Gly Gly Cys Pro Lys Pro Ala Ser Arg Trp Asp Cys 
                485                 490                 495     


His Ser Asn Gln Xaa Ala Phe His Gly Cys Met Glu Leu Leu Lys Val 
            500                 505                 510         


Asp Gly Gln Leu Val Asn Leu Xaa Leu Val Glu Gly Arg Arg Leu Gly 
        515                 520                 525             


Phe Tyr Ala Glu Val Leu Phe Asp Xaa Cys Gly Ile Xaa Asp Arg Cys 
    530                 535                 540                 


Ser Pro Asn Met Cys Glu His Asp Gly Arg Cys Tyr Gln Ser Trp Asp 
545                 550                 555                 560 


Asp Phe Ile Cys Tyr Cys Glu Leu Xaa Gly Tyr Lys Gly Glu Xaa Cys 
                565                 570                 575     


His Xaa Pro Leu Tyr Lys Glu Ser Cys Glu Ala Tyr Arg Leu Ser Gly 
            580                 585                 590         


Lys Xaa Ser Gly Asn Phe Xaa Ile Asp Pro Asp Gly Ser Gly Pro Leu 
        595                 600                 605             


Lys Pro Phe Val Val Tyr Cys Asp Ile Arg Glu Asn Arg Ala Trp Xaa 
    610                 615                 620                 


Val Val Arg His Asp Arg Leu Trp Xaa Xaa Arg Val Xaa Gly Ser Ser 
625                 630                 635                 640 


Met Glu Arg Pro Phe Leu Gly Ala Ile Gln Tyr Trp Asn Ala Ser Trp 
                645                 650                 655     


Glu Glu Val Ser Ala Leu Ala Asn Ala Ser Gln His Cys Glu Gln Trp 
            660                 665                 670         


Ile Glu Phe Ser Cys Tyr Asn Ser Arg Leu Leu Asn Xaa Ala Gly Gly 
        675                 680                 685             


Tyr Pro Tyr Ser Phe Trp Ile Gly Arg Asn Glu Glu Gln His Phe Tyr 
    690                 695                 700                 


Trp Gly Gly Ser Gln Pro Gly Ile Gln Arg Cys Ala Cys Gly Leu Asp 
705                 710                 715                 720 


Arg Ser Cys Val Asp Pro Ala Leu Tyr Cys Asn Cys Asp Ala Asp Gln 
                725                 730                 735     


Pro Gln Trp Arg Xaa Asp Lys Gly Leu Leu Xaa Phe Val Asp His Leu 
            740                 745                 750         


Pro Val Xaa Gln Val Val Ile Gly Asp Xaa Asn Arg Ser Xaa Ser Glu 
        755                 760                 765             


Ala Gln Phe Phe Leu Arg Pro Leu Arg Cys Tyr Gly Asp Arg Asn Ser 
    770                 775                 780                 


Trp Asn Xaa Ile Ser Phe His Xaa Gly Ala Ala Leu Arg Phe Pro Pro 
785                 790                 795                 800 


Ile Arg Ala Asn His Ser Leu Asp Val Ser Phe Tyr Phe Arg Xaa Ser 
                805                 810                 815     


Ala Pro Ser Gly Val Phe Leu Glu Asn Met Gly Gly Pro Tyr Cys Gln 
            820                 825                 830         


Trp Arg Arg Pro Tyr Val Arg Val Glu Leu Asn Xaa Ser Arg Asp Val 
        835                 840                 845             


Val Phe Ala Phe Asp Val Gly Asn Gly Asp Glu Asn Leu Xaa Val His 
    850                 855                 860                 


Ser Asp Asp Phe Glu Phe Asn Asp Asp Glu Trp His Leu Val Arg Ala 
865                 870                 875                 880 


Glu Ile Asn Val Lys Gln Ala Arg Leu Arg Val Asp His Arg Pro Trp 
                885                 890                 895     


Val Leu Arg Pro Met Pro Leu Gln Xaa Tyr Ile Trp Met Glu Tyr Asp 
            900                 905                 910         


Gln Pro Leu Tyr Val Gly Ser Ala Glu Leu Lys Arg Arg Pro Phe Val 
        915                 920                 925             


Gly Cys Leu Arg Ala Met Arg Leu Asn Gly Val Xaa Leu Asn Leu Glu 
    930                 935                 940                 


Gly Arg Ala Asn Ala Ser Glu Gly Xaa Ser Pro Asn Cys Xaa Gly His 
945                 950                 955                 960 


Cys Ala His Pro Arg Leu Pro Cys Phe His Gly Gly Arg Cys Val Glu 
                965                 970                 975     


Arg Tyr Ser Tyr Tyr Xaa Cys Asp Cys Asp Leu Xaa Ala Phe Asp Gly 
            980                 985                 990         


Pro Tyr Cys Asn His Asp Ile Gly  Gly Phe Phe Glu Pro  Gly Xaa Trp 
        995                 1000                 1005             


Met Arg  Tyr Asn Leu Gln Ser  Ala Leu Arg Ser Ala  Ala Arg Glu 
    1010                 1015                 1020             


Phe Ser  His Met Leu Ser Arg  Pro Val Pro Gly Tyr  Glu Pro Gly 
    1025                 1030                 1035             


Tyr Ile  Pro Gly Tyr Asp Xaa  Pro Gly Tyr Val Pro  Gly Tyr His 
    1040                 1045                 1050             


Gly Pro  Gly Tyr Arg Leu Pro  Asp Tyr Pro Arg Pro  Gly Arg Pro 
    1055                 1060                 1065             


Val Pro  Gly Tyr Arg Gly Pro  Val Tyr Asn Val Xaa  Gly Glu Glu 
    1070                 1075                 1080             


Val Ser  Phe Ser Phe Ser Xaa  Ser Ser Ala Pro Ala  Val Leu Leu 
    1085                 1090                 1095             


Tyr Val  Ser Ser Phe Val Arg  Asp Tyr Met Ala Val  Leu Ile Lys 
    1100                 1105                 1110             


Asp Asp  Gly Xaa Leu Gln Leu  Arg Tyr Gln Leu Gly  Xaa Ser Pro 
    1115                 1120                 1125             


Tyr Val  Tyr Gln Leu Xaa Xaa  Arg Pro Val Xaa Asp  Gly Gln Pro 
    1130                 1135                 1140             


His Ser  Ile Asn Ile Xaa Arg  Val Tyr Arg Asn Leu  Phe Ile Gln 
    1145                 1150                 1155             


Val Asp  Tyr Phe Pro Leu Xaa  Glu Gln Lys Phe Ser  Leu Leu Val 
    1160                 1165                 1170             


Asp Ser  Gln Leu Asp Ser Pro  Lys Ala Leu Tyr Leu  Gly Arg Val 
    1175                 1180                 1185             


Met Glu  Xaa Gly Val Ile Asp  Pro Glu Ile Gln Arg  Tyr Asn Xaa 
    1190                 1195                 1200             


Pro Gly  Phe Ser Gly Cys Leu  Ser Gly Val Arg Phe  Asn Asn Val 
    1205                 1210                 1215             


Ala Pro  Leu Lys Xaa His Phe  Arg Xaa Pro Arg Pro  Met Xaa Ala 
    1220                 1225                 1230             


Glu Leu  Ala Glu Ala Leu Arg  Val Gln Gly Glu Leu  Ser Glu Ser 
    1235                 1240                 1245             


Asn Cys  Gly Ala Met Pro Arg  Leu Val Ser Glu Val  Pro Pro Glu 
    1250                 1255                 1260             


Leu Asp  Pro Trp Tyr Leu Pro  Pro Asp Phe Pro Tyr  Tyr His Asp 
    1265                 1270                 1275             


Glu Gly  Trp Val Ala Ile Leu  Leu Gly Phe Leu Val  Ala Phe Leu 
    1280                 1285                 1290             


Leu Leu  Gly Leu Val Gly Met  Leu Val Leu Phe Tyr  Leu Gln Asn 
    1295                 1300                 1305             


His Arg  Tyr Lys Gly Ser Tyr  His Xaa Asn Glu Pro  Lys Ala Ala 
    1310                 1315                 1320             


His Glu  Tyr His Pro Gly Ser  Lys Pro Pro Leu Pro  Xaa Ser Gly 
    1325                 1330                 1335             


Pro Ala  Gln Val Pro Xaa Pro  Xaa Ala Ala Pro Asn  Gln Ala Pro 
    1340                 1345                 1350             


Ala Ser  Ala Pro Ala Pro Ala  Pro Xaa Pro Ala Pro  Ala Pro Gly 
    1355                 1360                 1365             


Pro Arg  Asp Gln Asn Leu Pro  Gln Ile Leu Glu Glu  Ser Arg Ser 
    1370                 1375                 1380             


Glu 
    


<210> 6637
<211> 1388
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1314)..(1314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1344)..(1344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1347)..(1347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1384)..(1384)
<223> Selenocysteine

<400> 6637
Met Ala Pro Arg Arg Asn Asn Gly Gln Cys Trp Cys Leu Leu Met Leu 
1               5                   10                  15      


Leu Ser Val Ser Xaa Pro Leu Pro Ala Val Xaa Gln Xaa Arg Gly Ala 
            20                  25                  30          


Xaa Glu Xaa Ala Ser Gln Gly His Leu Asp Leu Xaa Gln Leu Ile Gly 
        35                  40                  45              


Val Pro Leu Pro Ser Ser Val Ser Phe Val Xaa Gly Tyr Gly Gly Phe 
    50                  55                  60                  


Pro Ala Tyr Ser Phe Gly Pro Gly Ala Asn Val Gly Arg Pro Ala Arg 
65                  70                  75                  80  


Xaa Leu Ile Pro Ser Xaa Phe Phe Arg Asp Phe Ala Ile Ser Val Val 
                85                  90                  95      


Val Lys Pro Ser Ser Xaa Arg Gly Gly Val Leu Phe Ala Ile Xaa Asp 
            100                 105                 110         


Ala Phe Gln Lys Val Ile Tyr Leu Gly Leu Arg Leu Ser Gly Val Glu 
        115                 120                 125             


Asp Gly His Gln Arg Ile Ile Leu Tyr Tyr Xaa Glu Pro Gly Ser His 
    130                 135                 140                 


Val Ser Gln Glu Ala Ala Ala Phe Ser Val Pro Val Met Xaa His Arg 
145                 150                 155                 160 


Trp Asn Arg Phe Ala Met Ile Val Gln Gly Glu Glu Val Xaa Leu Leu 
                165                 170                 175     


Val Asn Cys Glu Glu His Ser Arg Ile Pro Phe Gln Arg Ser Ser Gln 
            180                 185                 190         


Ala Leu Ala Phe Glu Ser Ser Ala Gly Ile Phe Met Gly Asn Ala Gly 
        195                 200                 205             


Ala Xaa Gly Leu Glu Arg Phe Xaa Gly Ser Leu Gln Gln Leu Xaa Val 
    210                 215                 220                 


His Pro Asp Pro Arg Xaa Pro Glu Glu Leu Cys Asp Pro Glu Glu Ser 
225                 230                 235                 240 


Ser Ala Ser Gly Glu Xaa Ser Gly Leu Gln Glu Ala Asp Gly Val Ala 
                245                 250                 255     


Glu Ile Leu Glu Ala Val Xaa Tyr Xaa Gln Ala Ser Pro Lys Glu Ala 
            260                 265                 270         


Lys Val Glu Pro Ile Asn Xaa Pro Pro Xaa Pro Ser Ser Pro Phe Glu 
        275                 280                 285             


Asp Met Glu Leu Ser Gly Glu Pro Val Pro Glu Gly Xaa Leu Glu Xaa 
    290                 295                 300                 


Xaa Asn Met Ser Ile Ile Gln His Ser Ser Pro Lys Gln Gly Ser Gly 
305                 310                 315                 320 


Glu Ile Leu Asn Asp Xaa Leu Glu Gly Val His Ser Val Asp Gly Asp 
                325                 330                 335     


Pro Ile Xaa Asp Ser Gly Ser Gly Ala Gly Ala Phe Leu Asp Ile Ala 
            340                 345                 350         


Glu Glu Lys Asn Leu Ala Ala Xaa Ala Ala Gly Leu Ala Glu Val Pro 
        355                 360                 365             


Ile Ser Xaa Ala Gly Glu Ala Glu Ala Ser Ser Val Pro Xaa Gly Gly 
    370                 375                 380                 


Pro Xaa Leu Ser Met Ser Xaa Glu Asn Pro Glu Glu Gly Val Xaa Pro 
385                 390                 395                 400 


Gly Pro Asp Asn Glu Glu Arg Leu Ala Ala Xaa Ala Ala Gly Glu Ala 
                405                 410                 415     


Glu Ala Leu Ala Ser Met Pro Gly Glu Val Glu Ala Ser Gly Val Ala 
            420                 425                 430         


Pro Gly Glu Leu Asp Leu Ser Met Ser Ala Gln Ser Leu Gly Glu Glu 
        435                 440                 445             


Ala Xaa Val Gly Pro Ser Ser Glu Asp Ser Leu Xaa Xaa Ala Ala Ala 
    450                 455                 460                 


Ala Xaa Glu Val Ser Leu Ser Xaa Phe Glu Asp Glu Glu Ala Ser Gly 
465                 470                 475                 480 


Val Pro Xaa Asp Gly Leu Ala Pro Leu Xaa Ala Xaa Met Ala Pro Glu 
                485                 490                 495     


Arg Ala Val Xaa Ser Gly Pro Gly Asp Glu Glu Asp Leu Ala Ala Ala 
            500                 505                 510         


Xaa Xaa Glu Glu Pro Leu Ile Xaa Ala Gly Gly Glu Glu Ser Gly Ser 
        515                 520                 525             


Pro Pro Pro Asp Gly Pro Pro Leu Pro Leu Pro Xaa Val Ala Pro Glu 
    530                 535                 540                 


Arg Trp Ile Xaa Pro Ala Gln Arg Glu His Val Gly Met Lys Gly Gln 
545                 550                 555                 560 


Ala Gly Pro Lys Gly Glu Lys Gly Asp Ala Gly Glu Glu Leu Pro Gly 
                565                 570                 575     


Pro Pro Glu Pro Ser Gly Pro Val Gly Pro Xaa Ala Gly Ala Glu Ala 
            580                 585                 590         


Glu Gly Ser Gly Leu Gly Trp Gly Ser Asp Val Gly Ser Gly Ser Gly 
        595                 600                 605             


Asp Leu Val Gly Ser Glu Gln Leu Leu Arg Gly Pro Pro Gly Pro Pro 
    610                 615                 620                 


Gly Pro Pro Gly Leu Pro Gly Ile Pro Gly Lys Pro Gly Xaa Asp Val 
625                 630                 635                 640 


Phe Met Gly Pro Pro Gly Ser Pro Gly Glu Asp Gly Pro Ala Gly Glu 
                645                 650                 655     


Pro Gly Pro Pro Gly Pro Glu Gly Gln Pro Gly Val Asp Gly Ala Xaa 
            660                 665                 670         


Gly Leu Pro Gly Met Lys Gly Glu Lys Gly Ala Arg Gly Pro Asn Gly 
        675                 680                 685             


Ser Val Gly Glu Lys Gly Asp Pro Gly Asn Arg Gly Leu Pro Gly Pro 
    690                 695                 700                 


Pro Gly Lys Lys Gly Gln Ala Gly Pro Pro Gly Val Met Gly Pro Pro 
705                 710                 715                 720 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly Cys Xaa Met Gly 
                725                 730                 735     


Leu Gly Phe Glu Asp Xaa Glu Gly Ser Gly Ser Xaa Gln Leu Leu Asn 
            740                 745                 750         


Glu Pro Lys Leu Ser Arg Pro Xaa Ala Ala Ile Gly Leu Lys Gly Glu 
        755                 760                 765             


Lys Gly Asp Arg Gly Pro Lys Gly Glu Arg Gly Met Asp Gly Ala Ser 
    770                 775                 780                 


Ile Val Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly His Ile Lys Val 
785                 790                 795                 800 


Leu Ser Asn Ser Leu Ile Asn Ile Xaa His Gly Phe Met Asn Phe Ser 
                805                 810                 815     


Asp Ile Pro Glu Leu Val Gly Pro Pro Gly Pro Asp Gly Leu Pro Gly 
            820                 825                 830         


Leu Pro Gly Phe Pro Gly Pro Arg Gly Pro Lys Gly Asp Xaa Gly Leu 
        835                 840                 845             


Pro Gly Phe Pro Gly Leu Lys Gly Glu Gln Gly Glu Lys Gly Glu Pro 
    850                 855                 860                 


Gly Ala Ile Leu Xaa Glu Asp Ile Pro Leu Glu Arg Leu Met Gly Lys 
865                 870                 875                 880 


Lys Gly Glu Pro Gly Met His Gly Ala Pro Gly Pro Met Gly Pro Lys 
                885                 890                 895     


Gly Pro Pro Gly His Lys Gly Glu Phe Gly Leu Pro Gly Arg Pro Gly 
            900                 905                 910         


Arg Pro Gly Leu Asn Gly Leu Lys Gly Xaa Lys Gly Asp Pro Gly Val 
        915                 920                 925             


Ile Met Gln Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly 
    930                 935                 940                 


Pro Pro Gly Ala Val Ile Asn Ile Lys Gly Ala Ile Phe Pro Ile Pro 
945                 950                 955                 960 


Val Arg Pro His Cys Lys Met Pro Val Asp Xaa Ala His Pro Gly Ser 
                965                 970                 975     


Pro Glu Leu Ile Xaa Phe His Gly Val Lys Gly Glu Lys Gly Ser Trp 
            980                 985                 990         


Gly Leu Pro Gly Ser Lys Gly Glu  Lys Gly Asp Gln Gly  Ala Gln Gly 
        995                 1000                 1005             


Pro Pro  Gly Pro Pro Leu Asp  Leu Ala Tyr Leu Arg  His Phe Leu 
    1010                 1015                 1020             


Asn Asn  Leu Lys Gly Glu Asn  Gly Asp Lys Gly Phe  Lys Gly Glu 
    1025                 1030                 1035             


Lys Gly  Glu Lys Gly Asp Ile  Asn Gly Ser Phe Leu  Met Ser Gly 
    1040                 1045                 1050             


Pro Pro  Gly Leu Pro Gly Asn  Pro Gly Pro Ala Gly  Gln Lys Gly 
    1055                 1060                 1065             


Glu Xaa  Val Val Gly Pro Gln  Gly Pro Pro Gly Ala  Pro Gly Leu 
    1070                 1075                 1080             


Pro Gly  Pro Pro Gly Phe Gly  Arg Pro Gly Asp Pro  Gly Pro Pro 
    1085                 1090                 1095             


Gly Pro  Pro Gly Pro Pro Gly  Pro Pro Ala Ile Leu  Gly Ala Ala 
    1100                 1105                 1110             


Val Ala  Leu Pro Gly Pro Pro  Gly Pro Pro Gly Gln  Pro Gly Leu 
    1115                 1120                 1125             


Pro Gly  Ser Arg Asn Leu Val  Xaa Ala Phe Ser Asn  Met Asp Asp 
    1130                 1135                 1140             


Met Leu  Gln Lys Ala His Leu  Val Ile Glu Gly Xaa  Phe Ile Tyr 
    1145                 1150                 1155             


Leu Arg  Asp Ser Xaa Glu Phe  Phe Ile Arg Val Arg  Asp Gly Trp 
    1160                 1165                 1170             


Lys Lys  Leu Gln Leu Gly Glu  Leu Ile Pro Ile Pro  Ala Asp Ser 
    1175                 1180                 1185             


Pro Pro  Pro Pro Ala Leu Ser  Ser Asn Pro His Gln  Leu Leu Pro 
    1190                 1195                 1200             


Pro Pro  Asn Pro Ile Ser Ser  Ala Asn Tyr Glu Lys  Pro Ala Leu 
    1205                 1210                 1215             


His Leu  Ala Ala Leu Asn Met  Pro Phe Ser Gly Asp  Ile Arg Ala 
    1220                 1225                 1230             


Asp Phe  Gln Cys Phe Lys Gln  Ala Arg Ala Ala Gly  Leu Leu Ser 
    1235                 1240                 1245             


Xaa Tyr  Arg Ala Phe Leu Ser  Ser His Leu Gln Asp  Leu Ser Xaa 
    1250                 1255                 1260             


Ile Val  Arg Lys Ala Glu Arg  Tyr Ser Leu Pro Ile  Val Asn Leu 
    1265                 1270                 1275             


Lys Gly  Gln Val Leu Phe Asn  Asn Trp Asp Ser Ile  Phe Ser Gly 
    1280                 1285                 1290             


His Gly  Gly Gln Phe Asn Met  His Ile Pro Ile Tyr  Ser Phe Asp 
    1295                 1300                 1305             


Gly Arg  Asp Ile Met Xaa Asp  Pro Ser Trp Pro Gln  Lys Val Ile 
    1310                 1315                 1320             


Trp His  Gly Ser Ser Pro His  Gly Val Arg Leu Val  Asp Asn Tyr 
    1325                 1330                 1335             


Cys Glu  Ala Trp Arg Xaa Ala  Asp Xaa Ala Val Xaa  Gly Leu Ala 
    1340                 1345                 1350             


Ser Pro  Leu Ser Xaa Gly Lys  Ile Leu Asp Gln Lys  Ala Tyr Ser 
    1355                 1360                 1365             


Cys Ala  Asn Arg Leu Ile Val  Leu Cys Ile Glu Asn  Ser Phe Met 
    1370                 1375                 1380             


Xaa Asp  Ala Arg Lys 
    1385             


<210> 6638
<211> 1374
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (957)..(957)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1235)..(1235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1249)..(1249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1300)..(1300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1330)..(1330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1344)..(1344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<400> 6638
Met Leu Leu Ser Val Ser Xaa Pro Leu Pro Ala Val Xaa Gln Xaa Arg 
1               5                   10                  15      


Gly Ala Xaa Glu Xaa Ala Ser Gln Gly His Leu Asp Leu Xaa Gln Leu 
            20                  25                  30          


Ile Gly Val Pro Leu Pro Ser Ser Val Ser Phe Val Xaa Gly Tyr Gly 
        35                  40                  45              


Gly Phe Pro Ala Tyr Ser Phe Gly Pro Gly Ala Asn Val Gly Arg Pro 
    50                  55                  60                  


Ala Arg Xaa Leu Ile Pro Ser Xaa Phe Phe Arg Asp Phe Ala Ile Ser 
65                  70                  75                  80  


Val Val Val Lys Pro Ser Ser Xaa Arg Gly Gly Val Leu Phe Ala Ile 
                85                  90                  95      


Xaa Asp Ala Phe Gln Lys Val Ile Tyr Leu Gly Leu Arg Leu Ser Gly 
            100                 105                 110         


Val Glu Asp Gly His Gln Arg Ile Ile Leu Tyr Tyr Xaa Glu Pro Gly 
        115                 120                 125             


Ser His Val Ser Gln Glu Ala Ala Ala Phe Ser Val Pro Val Met Xaa 
    130                 135                 140                 


His Arg Trp Asn Arg Phe Ala Met Ile Val Gln Gly Glu Glu Val Xaa 
145                 150                 155                 160 


Leu Leu Val Asn Cys Glu Glu His Ser Arg Ile Pro Phe Gln Arg Ser 
                165                 170                 175     


Ser Gln Ala Leu Ala Phe Glu Ser Ser Ala Gly Ile Phe Met Gly Asn 
            180                 185                 190         


Ala Gly Ala Xaa Gly Leu Glu Arg Phe Xaa Gly Ser Leu Gln Gln Leu 
        195                 200                 205             


Xaa Val His Pro Asp Pro Arg Xaa Pro Glu Glu Leu Cys Asp Pro Glu 
    210                 215                 220                 


Glu Ser Ser Ala Ser Gly Glu Xaa Ser Gly Leu Gln Glu Ala Asp Gly 
225                 230                 235                 240 


Val Ala Glu Ile Leu Glu Ala Val Xaa Tyr Xaa Gln Ala Ser Pro Lys 
                245                 250                 255     


Glu Ala Lys Val Glu Pro Ile Asn Xaa Pro Pro Xaa Pro Ser Ser Pro 
            260                 265                 270         


Phe Glu Asp Met Glu Leu Ser Gly Glu Pro Val Pro Glu Gly Xaa Leu 
        275                 280                 285             


Glu Xaa Xaa Asn Met Ser Ile Ile Gln His Ser Ser Pro Lys Gln Gly 
    290                 295                 300                 


Lys Gly Ala Ile Leu Asn Asp Xaa Leu Glu Gly Val His Ser Val Asp 
305                 310                 315                 320 


Gly Asp Pro Ile Xaa Asp Ser Gly Ser Gly Ala Gly Ala Phe Leu Asp 
                325                 330                 335     


Ile Ala Glu Glu Lys Asn Leu Ala Ala Xaa Ala Ala Gly Leu Ala Glu 
            340                 345                 350         


Val Pro Ile Ser Xaa Ala Gly Glu Ala Glu Ala Ser Ser Val Pro Xaa 
        355                 360                 365             


Gly Gly Pro Xaa Leu Ser Met Ser Xaa Glu Asn Pro Glu Glu Gly Val 
    370                 375                 380                 


Xaa Pro Gly Pro Asp Asn Glu Glu Arg Leu Ala Ala Xaa Ala Ala Gly 
385                 390                 395                 400 


Glu Ala Glu Ala Leu Ala Ser Met Pro Gly Glu Val Glu Ala Ser Gly 
                405                 410                 415     


Val Ala Pro Gly Glu Leu Asp Leu Ser Met Ser Ala Gln Ser Leu Gly 
            420                 425                 430         


Glu Glu Ala Xaa Val Gly Pro Ser Ser Glu Asp Ser Leu Xaa Xaa Ala 
        435                 440                 445             


Ala Ala Ala Xaa Glu Val Ser Leu Ser Xaa Phe Glu Asp Glu Glu Ala 
    450                 455                 460                 


Ser Gly Val Pro Xaa Asp Gly Leu Ala Pro Leu Xaa Ala Xaa Met Ala 
465                 470                 475                 480 


Pro Glu Arg Ala Val Xaa Ser Gly Pro Gly Asp Glu Glu Asp Leu Ala 
                485                 490                 495     


Ala Ala Xaa Xaa Glu Glu Pro Leu Ile Xaa Ala Gly Gly Glu Glu Ser 
            500                 505                 510         


Gly Ser Pro Pro Pro Asp Gly Pro Pro Leu Pro Leu Pro Xaa Val Ala 
        515                 520                 525             


Pro Glu Arg Trp Ile Xaa Pro Ala Gln Arg Glu His Val Gly Met Lys 
    530                 535                 540                 


Gly Gln Ala Gly Pro Lys Gly Glu Lys Gly Asp Ala Gly Glu Glu Leu 
545                 550                 555                 560 


Pro Gly Pro Pro Glu Pro Ser Gly Pro Val Gly Pro Xaa Ala Gly Ala 
                565                 570                 575     


Glu Ala Glu Gly Ser Gly Leu Gly Trp Gly Ser Asp Val Gly Ser Gly 
            580                 585                 590         


Ser Gly Asp Leu Val Gly Ser Glu Gln Leu Leu Arg Gly Pro Pro Gly 
        595                 600                 605             


Pro Pro Gly Pro Pro Gly Leu Pro Gly Ile Pro Gly Lys Pro Gly Xaa 
    610                 615                 620                 


Asp Val Phe Met Gly Pro Pro Gly Ser Pro Gly Glu Asp Gly Pro Ala 
625                 630                 635                 640 


Gly Glu Pro Gly Pro Pro Gly Pro Glu Gly Gln Pro Gly Val Asp Gly 
                645                 650                 655     


Ala Xaa Gly Leu Pro Gly Met Lys Gly Glu Lys Gly Ala Arg Gly Pro 
            660                 665                 670         


Asn Gly Ser Val Gly Glu Lys Gly Asp Pro Gly Asn Arg Gly Leu Pro 
        675                 680                 685             


Gly Pro Pro Gly Lys Lys Gly Gln Ala Gly Pro Pro Gly Val Met Gly 
    690                 695                 700                 


Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly Cys Xaa 
705                 710                 715                 720 


Met Gly Leu Gly Phe Glu Asp Xaa Glu Gly Ser Gly Ser Xaa Gln Leu 
                725                 730                 735     


Leu Asn Glu Pro Lys Leu Ser Arg Pro Xaa Ala Ala Ile Gly Leu Lys 
            740                 745                 750         


Gly Glu Lys Gly Asp Arg Gly Pro Lys Gly Glu Arg Gly Met Asp Gly 
        755                 760                 765             


Ala Ser Ile Val Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly His Ile 
    770                 775                 780                 


Lys Val Leu Ser Asn Ser Leu Ile Asn Ile Xaa His Gly Phe Met Asn 
785                 790                 795                 800 


Phe Ser Asp Ile Pro Glu Leu Val Gly Pro Pro Gly Pro Asp Gly Leu 
                805                 810                 815     


Pro Gly Leu Pro Gly Phe Pro Gly Pro Arg Gly Pro Lys Gly Asp Xaa 
            820                 825                 830         


Gly Leu Pro Gly Phe Pro Gly Leu Lys Gly Glu Gln Gly Glu Lys Gly 
        835                 840                 845             


Glu Pro Gly Ala Ile Leu Xaa Glu Asp Ile Pro Leu Glu Arg Leu Met 
    850                 855                 860                 


Gly Lys Lys Gly Glu Pro Gly Met His Gly Ala Pro Gly Pro Met Gly 
865                 870                 875                 880 


Pro Lys Gly Pro Pro Gly His Lys Gly Glu Phe Gly Leu Pro Gly Arg 
                885                 890                 895     


Pro Gly Arg Pro Gly Leu Asn Gly Leu Lys Gly Xaa Lys Gly Asp Pro 
            900                 905                 910         


Gly Val Ile Met Gln Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro 
        915                 920                 925             


Pro Gly Pro Pro Gly Ala Val Ile Asn Ile Lys Gly Ala Ile Phe Pro 
    930                 935                 940                 


Ile Pro Val Arg Pro His Cys Lys Met Pro Val Asp Xaa Ala His Pro 
945                 950                 955                 960 


Gly Ser Pro Glu Leu Ile Xaa Phe His Gly Val Lys Gly Glu Lys Gly 
                965                 970                 975     


Ser Trp Gly Leu Pro Gly Ser Lys Gly Glu Lys Gly Asp Gln Gly Ala 
            980                 985                 990         


Gln Gly Pro Pro Gly Pro Pro Leu  Asp Leu Ala Tyr Leu  Arg His Phe 
        995                 1000                 1005             


Leu Asn  Asn Leu Lys Gly Glu  Asn Gly Asp Lys Gly  Phe Lys Gly 
    1010                 1015                 1020             


Glu Lys  Gly Glu Lys Gly Asp  Ile Asn Gly Ser Phe  Leu Met Ser 
    1025                 1030                 1035             


Gly Pro  Pro Gly Leu Pro Gly  Asn Pro Gly Pro Ala  Gly Gln Lys 
    1040                 1045                 1050             


Gly Glu  Xaa Val Val Gly Pro  Gln Gly Pro Pro Gly  Ala Pro Gly 
    1055                 1060                 1065             


Leu Pro  Gly Pro Pro Gly Phe  Gly Arg Pro Gly Asp  Pro Gly Pro 
    1070                 1075                 1080             


Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Ala Ile  Leu Gly Ala 
    1085                 1090                 1095             


Ala Val  Ala Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Gln Pro Gly 
    1100                 1105                 1110             


Leu Pro  Gly Ser Arg Asn Leu  Val Xaa Ala Phe Ser  Asn Met Asp 
    1115                 1120                 1125             


Asp Met  Leu Gln Lys Ala His  Leu Val Ile Glu Gly  Xaa Phe Ile 
    1130                 1135                 1140             


Tyr Leu  Arg Asp Ser Xaa Glu  Phe Phe Ile Arg Val  Arg Asp Gly 
    1145                 1150                 1155             


Trp Lys  Lys Leu Gln Leu Gly  Glu Leu Ile Pro Ile  Pro Ala Asp 
    1160                 1165                 1170             


Ser Pro  Pro Pro Pro Ala Leu  Ser Ser Asn Pro His  Gln Leu Leu 
    1175                 1180                 1185             


Pro Pro  Pro Asn Pro Ile Ser  Ser Ala Asn Tyr Glu  Lys Pro Ala 
    1190                 1195                 1200             


Leu His  Leu Ala Ala Leu Asn  Met Pro Phe Ser Gly  Asp Ile Arg 
    1205                 1210                 1215             


Ala Asp  Phe Gln Cys Phe Lys  Gln Ala Arg Ala Ala  Gly Leu Leu 
    1220                 1225                 1230             


Ser Xaa  Tyr Arg Ala Phe Leu  Ser Ser His Leu Gln  Asp Leu Ser 
    1235                 1240                 1245             


Xaa Ile  Val Arg Lys Ala Glu  Arg Tyr Ser Leu Pro  Ile Val Asn 
    1250                 1255                 1260             


Leu Lys  Gly Gln Val Leu Phe  Asn Asn Trp Asp Ser  Ile Phe Ser 
    1265                 1270                 1275             


Gly His  Gly Gly Gln Phe Asn  Met His Ile Pro Ile  Tyr Ser Phe 
    1280                 1285                 1290             


Asp Gly  Arg Asp Ile Met Xaa  Asp Pro Ser Trp Pro  Gln Lys Val 
    1295                 1300                 1305             


Ile Trp  His Gly Ser Ser Pro  His Gly Val Arg Leu  Val Asp Asn 
    1310                 1315                 1320             


Tyr Cys  Glu Ala Trp Arg Xaa  Ala Asp Xaa Ala Val  Xaa Gly Leu 
    1325                 1330                 1335             


Ala Ser  Pro Leu Ser Xaa Gly  Lys Ile Leu Asp Gln  Lys Ala Tyr 
    1340                 1345                 1350             


Ser Cys  Ala Asn Arg Leu Ile  Val Leu Cys Ile Glu  Asn Ser Phe 
    1355                 1360                 1365             


Met Xaa  Asp Ala Arg Lys 
    1370                 


<210> 6639
<211> 235
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<400> 6639
Gly Glu Pro Gly Pro Pro Gly Arg Gly Val Gln Gly Pro Gln Gly Glu 
1               5                   10                  15      


Pro Gly Ala Pro Gly Leu Pro Gly Ile Gln Gly Leu Pro Gly Pro Arg 
            20                  25                  30          


Gly Pro Pro Gly Pro Xaa Gly Glu Lys Gly Ala Gln Gly Ser Pro Gly 
        35                  40                  45              


Val Lys Gly Ala Xaa Gly Pro Val Gly Pro Pro Gly Ala Ser Val Ser 
    50                  55                  60                  


Gly Pro Pro Gly Arg Asp Gly Gln Gln Gly Gln Xaa Gly Leu Arg Gly 
65                  70                  75                  80  


Xaa Pro Gly Glu Lys Gly Pro Arg Gly Glu Lys Gly Glu Pro Gly Glu 
                85                  90                  95      


Cys Ser Cys Pro Ser Gln Gly Asp Leu Ile Phe Ser Gly Met Pro Gly 
            100                 105                 110         


Pro Pro Gly Ile Pro Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Leu 
        115                 120                 125             


Gln Gly Val Pro Gly Asn Asn Gly Leu Pro Gly Gln Pro Gly Leu Xaa 
    130                 135                 140                 


Ala Glu Leu Gly Ser Leu Pro Ile Glu Gln His Leu Leu Lys Ser Ile 
145                 150                 155                 160 


Cys Gly Asp Cys Val Gln Gly Gln Arg Ala His Pro Gly Tyr Leu Val 
                165                 170                 175     


Glu Lys Gly Glu Lys Gly Asp Gln Gly Ile Pro Gly Val Pro Gly Leu 
            180                 185                 190         


Asp Asn Cys Ala Gln Cys Phe Leu Ser Leu Glu Arg Pro Arg Ala Glu 
        195                 200                 205             


Glu Ala Arg Gly Asp Asn Ser Glu Gly Asp Pro Gly Cys Val Gly Ser 
    210                 215                 220                 


Pro Gly Leu Pro Gly Pro Pro Gly Leu Pro Gly 
225                 230                 235 


<210> 6640
<211> 224
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<400> 6640
Gly Pro Pro Gly Ser Glu Gly Leu Pro Gly Pro Pro Gly Pro Ala Gly 
1               5                   10                  15      


Pro Arg Gly Glu Arg Gly Pro Gln Gly Asn Ser Gly Glu Lys Gly Asp 
            20                  25                  30          


Gln Gly Phe Gln Gly Gln Pro Gly Phe Pro Gly Pro Pro Gly Pro Pro 
        35                  40                  45              


Gly Phe Pro Gly Lys Val Gly Ser Pro Gly Pro Pro Gly Pro Gln Ala 
    50                  55                  60                  


Glu Lys Gly Pro Ala Gly Leu Asp Gly Leu Asp Gly Lys Asp Gly Lys 
65                  70                  75                  80  


Pro Gly Leu Arg Gly Asp Pro Gly Pro Ala Gly Pro Pro Gly Leu Met 
                85                  90                  95      


Gly Pro Pro Gly Phe Lys Gly Lys Xaa Gly His Pro Gly Leu Pro Gly 
            100                 105                 110         


Pro Lys Gly Asp Cys Gly Lys Pro Gly Pro Pro Gly Ser Xaa Gly Arg 
        115                 120                 125             


Pro Gly Ala Glu Gly Glu Pro Gly Ala Met Gly Pro Gln Gly Arg Pro 
    130                 135                 140                 


Gly Pro Pro Gly His Val Gly Pro Pro Gly Pro Pro Gly Gln Pro Gly 
145                 150                 155                 160 


Pro Ala Gly Ile Ser Ala Val Gly Leu Lys Gly Asp Arg Gly Ala Xaa 
                165                 170                 175     


Gly Glu Arg Gly Leu Ala Gly Leu Pro Gly Gln Pro Gly Pro Pro Gly 
            180                 185                 190         


His Pro Gly Pro Pro Gly Glu Pro Gly Xaa Asp Gly Ala Ala Gly Lys 
        195                 200                 205             


Glu Gly Pro Pro Gly Lys Gln Gly Phe Tyr Gly Pro Pro Gly Pro Lys 
    210                 215                 220                 


<210> 6641
<211> 308
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<400> 6641
Lys Val Tyr Xaa Arg Cys Phe Cys Leu Glu Glu Pro Gln Asn Ser Glu 
1               5                   10                  15      


Val Asp Ala Gln Leu Xaa Gly Arg Ile Ser Gln Lys Ala Glu Arg Gly 
            20                  25                  30          


Ala Lys Val His Gln Glu Xaa Ala Ala Asp Glu Cys Pro Pro Cys Val 
        35                  40                  45              


His Gly Ala Arg Asp Ser Asn Gly Gly Lys Gly Glu Arg Gly Leu Pro 
    50                  55                  60                  


Gly Pro Pro Gly Ser Lys Gly Glu Lys Gly Ala Arg Gly Asn Asp Cys 
65                  70                  75                  80  


Val Arg Ile Ser Pro Asp Ala Pro Leu Gln Cys Ala Glu Gly Pro Lys 
                85                  90                  95      


Gly Glu Lys Gly Glu Ser Gly Ala Leu Gly Pro Ser Gly Leu Pro Gly 
            100                 105                 110         


Ser Xaa Gly Glu Lys Gly Gln Lys Gly Glu Lys Gly Asp Gly Gly Ile 
        115                 120                 125             


Lys Gly Val Pro Gly Lys Pro Gly Arg Asp Gly Arg Pro Gly Glu Ile 
    130                 135                 140                 


Cys Val Ile Gly Pro Lys Gly Gln Lys Gly Asp Pro Gly Phe Val Gly 
145                 150                 155                 160 


Pro Glu Gly Leu Ala Gly Glu Pro Gly Pro Pro Gly Leu Pro Gly Pro 
                165                 170                 175     


Pro Gly Ile Gly Leu Pro Gly Xaa Pro Gly Asp Pro Gly Gly Pro Pro 
            180                 185                 190         


Gly Pro Lys Gly Asp Lys Gly Ser Ser Gly Ile Pro Gly Lys Glu Gly 
        195                 200                 205             


Pro Gly Gly Lys Pro Gly Lys Pro Gly Val Lys Gly Glu Lys Gly Asp 
    210                 215                 220                 


Pro Cys Glu Val Cys Pro Xaa Leu Pro Glu Gly Phe Gln Asn Phe Val 
225                 230                 235                 240 


Gly Leu Pro Gly Lys Pro Gly Pro Lys Gly Glu Pro Gly Asp Pro Val 
                245                 250                 255     


Pro Ala Arg Gly Asp Pro Gly Ile Gln Gly Ile Lys Gly Glu Lys Gly 
            260                 265                 270         


Glu Pro Cys Leu Ser Cys Ser Ser Val Val Gly Ala Gln His Leu Val 
        275                 280                 285             


Ser Ser Xaa Gly Ala Ser Gly Asp Val Gly Ser Pro Gly Phe Gly Leu 
    290                 295                 300                 


Pro Gly Leu Pro 
305             


<210> 6642
<211> 966
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<400> 6642
Met Trp Val Ser Trp Ala Pro Gly Leu Trp Leu Leu Gly Leu Trp Ala 
1               5                   10                  15      


Xaa Phe Gly His Gly Ala Asn Xaa Gly Ala Gln Cys Pro Pro Ser Gln 
            20                  25                  30          


Gln Glu Gly Leu Lys Leu Glu His Ser Ser Ser Leu Pro Ala Asn Val 
        35                  40                  45              


Xaa Gly Phe Asn Leu Ile His Arg Leu Ser Leu Met Lys Xaa Ser Ala 
    50                  55                  60                  


Ile Lys Lys Ile Arg Asn Pro Lys Gly Pro Leu Ile Leu Arg Leu Gly 
65                  70                  75                  80  


Ala Ala Pro Val Xaa Gln Pro Xaa Arg Arg Val Phe Pro Arg Gly Leu 
                85                  90                  95      


Pro Glu Glu Phe Ala Leu Val Leu Xaa Leu Leu Leu Lys Lys His Xaa 
            100                 105                 110         


His Gln Lys Xaa Trp Tyr Leu Phe Gln Val Xaa Asp Ala Asn Gly Tyr 
        115                 120                 125             


Pro Gln Ile Ser Leu Glu Val Asn Ser Gln Glu Arg Ser Leu Glu Leu 
    130                 135                 140                 


Arg Ala Gln Gly Gln Asp Gly Asp Phe Val Ser Cys Ile Phe Pro Val 
145                 150                 155                 160 


Pro Gln Leu Phe Asp Leu Arg Trp His Lys Leu Met Leu Ser Val Ala 
                165                 170                 175     


Gly Arg Val Ala Ser Val His Val Asp Cys Ser Ser Ala Ser Ser Gln 
            180                 185                 190         


Pro Leu Gly Pro Arg Arg Pro Met Arg Pro Val Gly His Val Phe Leu 
        195                 200                 205             


Gly Leu Asp Ala Glu Gln Gly Lys Pro Val Ser Phe Asp Leu Gln Gln 
    210                 215                 220                 


Val His Ile Tyr Cys Asp Pro Glu Leu Val Leu Glu Glu Gly Cys Cys 
225                 230                 235                 240 


Glu Ile Leu Pro Ala Gly Cys Pro Pro Glu Xaa Ser Lys Ala Arg Arg 
                245                 250                 255     


Asp Xaa Gln Ser Asn Glu Leu Ile Glu Ile Asn Pro Gln Ser Glu Gly 
            260                 265                 270         


Lys Val Tyr Xaa Arg Cys Phe Cys Leu Glu Glu Pro Gln Asn Ser Glu 
        275                 280                 285             


Val Asp Ala Gln Leu Xaa Gly Arg Ile Ser Gln Lys Ala Glu Arg Gly 
    290                 295                 300                 


Ala Lys Val His Gln Glu Xaa Ala Ala Asp Glu Cys Pro Pro Cys Val 
305                 310                 315                 320 


His Gly Ala Arg Asp Ser Asn Val Xaa Leu Ala Pro Ser Gly Pro Lys 
                325                 330                 335     


Gly Gly Lys Gly Glu Arg Gly Leu Pro Gly Pro Pro Gly Ser Lys Gly 
            340                 345                 350         


Glu Lys Gly Ala Arg Gly Asn Asp Cys Val Arg Ile Ser Pro Asp Ala 
        355                 360                 365             


Pro Leu Gln Cys Ala Glu Gly Pro Lys Gly Glu Lys Gly Glu Ser Gly 
    370                 375                 380                 


Ala Leu Gly Pro Ser Gly Leu Pro Gly Ser Xaa Gly Glu Lys Gly Gln 
385                 390                 395                 400 


Lys Gly Glu Lys Gly Asp Gly Gly Ile Lys Gly Val Pro Gly Lys Pro 
                405                 410                 415     


Gly Arg Asp Gly Arg Pro Gly Glu Ile Cys Val Ile Gly Pro Lys Gly 
            420                 425                 430         


Gln Lys Gly Asp Pro Gly Phe Val Gly Pro Glu Gly Leu Ala Gly Glu 
        435                 440                 445             


Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Ile Gly Leu Pro Gly 
    450                 455                 460                 


Xaa Pro Gly Asp Pro Gly Gly Pro Pro Gly Pro Lys Gly Asp Lys Gly 
465                 470                 475                 480 


Ser Ser Gly Ile Pro Gly Lys Glu Gly Pro Gly Gly Lys Pro Gly Lys 
                485                 490                 495     


Pro Gly Val Lys Gly Glu Lys Gly Asp Pro Cys Glu Val Cys Pro Xaa 
            500                 505                 510         


Leu Pro Glu Gly Phe Gln Asn Phe Val Gly Leu Pro Gly Lys Pro Gly 
        515                 520                 525             


Pro Lys Gly Glu Pro Gly Asp Pro Val Pro Ala Arg Gly Asp Pro Gly 
    530                 535                 540                 


Ile Gln Gly Ile Lys Gly Glu Lys Gly Glu Pro Cys Leu Ser Cys Ser 
545                 550                 555                 560 


Ser Val Val Gly Ala Gln His Leu Val Ser Ser Xaa Gly Ala Ser Gly 
                565                 570                 575     


Asp Val Gly Ser Pro Gly Phe Gly Leu Pro Gly Leu Pro Gly Arg Ala 
            580                 585                 590         


Gly Val Pro Gly Leu Lys Gly Glu Lys Gly Asn Phe Gly Glu Ala Gly 
        595                 600                 605             


Pro Ala Gly Ser Pro Gly Pro Pro Gly Pro Val Gly Pro Ala Gly Ile 
    610                 615                 620                 


Lys Gly Ala Lys Gly Glu Pro Cys Glu Pro Cys Pro Ala Leu Ser Asn 
625                 630                 635                 640 


Leu Gln Asp Gly Asp Val Arg Val Val Ala Leu Pro Gly Pro Ser Gly 
                645                 650                 655     


Glu Lys Gly Glu Pro Gly Pro Pro Gly Phe Gly Leu Pro Gly Lys Gln 
            660                 665                 670         


Gly Lys Ala Gly Glu Arg Gly Leu Lys Gly Gln Lys Gly Asp Ala Gly 
        675                 680                 685             


Asn Pro Gly Asp Pro Gly Xaa Pro Gly Xaa Xaa Gly Arg Pro Gly Leu 
    690                 695                 700                 


Ser Gly Glu Pro Gly Val Gln Gly Pro Ala Gly Pro Lys Gly Glu Lys 
705                 710                 715                 720 


Gly Asp Gly Cys Xaa Ala Cys Pro Ser Leu Gln Gly Xaa Val Xaa Asp 
                725                 730                 735     


Met Ala Gly Arg Pro Gly Gln Pro Gly Pro Lys Gly Glu Gln Gly Pro 
            740                 745                 750         


Glu Gly Val Gly Arg Pro Gly Lys Pro Gly Gln Pro Gly Leu Pro Gly 
        755                 760                 765             


Val Gln Gly Pro Pro Gly Leu Lys Gly Val Gln Gly Glu Pro Gly Pro 
    770                 775                 780                 


Pro Gly Arg Gly Val Gln Gly Pro Gln Gly Glu Pro Gly Ala Pro Gly 
785                 790                 795                 800 


Leu Pro Gly Ile Gln Gly Leu Pro Gly Pro Arg Gly Pro Pro Gly Pro 
                805                 810                 815     


Xaa Gly Glu Lys Gly Ala Gln Gly Ser Pro Gly Val Lys Gly Ala Xaa 
            820                 825                 830         


Gly Pro Val Gly Pro Pro Gly Ala Ser Val Ser Gly Pro Pro Gly Arg 
        835                 840                 845             


Asp Gly Gln Gln Gly Gln Xaa Gly Leu Arg Gly Xaa Pro Gly Glu Lys 
    850                 855                 860                 


Gly Pro Arg Gly Glu Lys Gly Glu Pro Gly Glu Cys Ser Cys Pro Ser 
865                 870                 875                 880 


Gln Gly Asp Leu Ile Phe Ser Gly Met Pro Gly Pro Pro Gly Ile Pro 
                885                 890                 895     


Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Leu Gln Val Lys Gly Glu 
            900                 905                 910         


Lys Arg Met Arg Ser Leu Gly Gly Arg Ala His Gly Ser Gly Trp Leu 
        915                 920                 925             


Leu Pro Ala Gly Pro Gln Gly Cys Cys Ser Pro Xaa Pro Lys Xaa Gln 
    930                 935                 940                 


Xaa Cys His Phe Ser Leu Leu Cys Leu Pro Ala Ser Gln Gly Gly Lys 
945                 950                 955                 960 


Glu Gly Pro Leu Ser Leu 
                965     


<210> 6643
<211> 1604
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1248)..(1248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1319)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1459)..(1459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1516)..(1516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1551)..(1551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1598)..(1598)
<223> Selenocysteine

<400> 6643
Met Trp Val Ser Trp Ala Pro Gly Leu Trp Leu Leu Gly Leu Trp Ala 
1               5                   10                  15      


Xaa Phe Gly His Gly Ala Asn Xaa Gly Ala Gln Cys Pro Pro Ser Gln 
            20                  25                  30          


Gln Glu Gly Leu Lys Leu Glu His Ser Ser Ser Leu Pro Ala Asn Val 
        35                  40                  45              


Xaa Gly Phe Asn Leu Ile His Arg Leu Ser Leu Met Lys Xaa Ser Ala 
    50                  55                  60                  


Ile Lys Lys Ile Arg Asn Pro Lys Gly Pro Leu Ile Leu Arg Leu Gly 
65                  70                  75                  80  


Ala Ala Pro Val Xaa Gln Pro Xaa Arg Arg Val Phe Pro Arg Gly Leu 
                85                  90                  95      


Pro Glu Glu Phe Ala Leu Val Leu Xaa Leu Leu Leu Lys Lys His Xaa 
            100                 105                 110         


His Gln Lys Xaa Trp Tyr Leu Phe Gln Val Xaa Asp Ala Asn Gly Tyr 
        115                 120                 125             


Pro Gln Ile Ser Leu Glu Val Asn Ser Gln Glu Arg Ser Leu Glu Leu 
    130                 135                 140                 


Arg Ala Gln Gly Gln Asp Gly Asp Phe Val Ser Cys Ile Phe Pro Val 
145                 150                 155                 160 


Pro Gln Leu Phe Asp Leu Arg Trp His Lys Leu Met Leu Ser Val Ala 
                165                 170                 175     


Gly Arg Val Ala Ser Val His Val Asp Cys Ser Ser Ala Ser Ser Gln 
            180                 185                 190         


Pro Leu Gly Pro Arg Arg Pro Met Arg Pro Val Gly His Val Phe Leu 
        195                 200                 205             


Gly Leu Asp Ala Glu Gln Gly Lys Pro Val Ser Phe Asp Leu Gln Gln 
    210                 215                 220                 


Val His Ile Tyr Cys Asp Pro Glu Leu Val Leu Glu Glu Gly Cys Cys 
225                 230                 235                 240 


Glu Ile Leu Pro Ala Gly Cys Pro Pro Glu Xaa Ser Lys Ala Arg Arg 
                245                 250                 255     


Asp Xaa Gln Ser Asn Glu Leu Ile Glu Ile Asn Pro Gln Ser Glu Gly 
            260                 265                 270         


Lys Val Tyr Xaa Arg Cys Phe Cys Leu Glu Glu Pro Gln Asn Ser Glu 
        275                 280                 285             


Val Asp Ala Gln Leu Xaa Gly Arg Ile Ser Gln Lys Ala Glu Arg Gly 
    290                 295                 300                 


Ala Lys Val His Gln Glu Xaa Ala Ala Asp Glu Cys Pro Pro Cys Val 
305                 310                 315                 320 


His Gly Ala Arg Asp Ser Asn Val Xaa Leu Ala Pro Ser Gly Pro Lys 
                325                 330                 335     


Gly Gly Lys Gly Glu Arg Gly Leu Pro Gly Pro Pro Gly Ser Lys Gly 
            340                 345                 350         


Glu Lys Gly Ala Arg Gly Asn Asp Cys Val Arg Ile Ser Pro Asp Ala 
        355                 360                 365             


Pro Leu Gln Cys Ala Glu Gly Pro Lys Gly Glu Lys Gly Glu Ser Gly 
    370                 375                 380                 


Ala Leu Gly Pro Ser Gly Leu Pro Gly Ser Xaa Gly Glu Lys Gly Gln 
385                 390                 395                 400 


Lys Gly Glu Lys Gly Asp Gly Gly Ile Lys Gly Val Pro Gly Lys Pro 
                405                 410                 415     


Gly Arg Asp Gly Arg Pro Gly Glu Ile Cys Val Ile Gly Pro Lys Gly 
            420                 425                 430         


Gln Lys Gly Asp Pro Gly Phe Val Gly Pro Glu Gly Leu Ala Gly Glu 
        435                 440                 445             


Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Ile Gly Leu Pro Gly 
    450                 455                 460                 


Xaa Pro Gly Asp Pro Gly Gly Pro Pro Gly Pro Lys Gly Asp Lys Gly 
465                 470                 475                 480 


Ser Ser Gly Ile Pro Gly Lys Glu Gly Pro Gly Gly Lys Pro Gly Lys 
                485                 490                 495     


Pro Gly Val Lys Gly Glu Lys Gly Asp Pro Cys Glu Val Cys Pro Xaa 
            500                 505                 510         


Leu Pro Glu Gly Phe Gln Asn Phe Val Gly Leu Pro Gly Lys Pro Gly 
        515                 520                 525             


Pro Lys Gly Glu Pro Gly Asp Pro Val Pro Ala Arg Gly Asp Pro Gly 
    530                 535                 540                 


Ile Gln Gly Ile Lys Gly Glu Lys Gly Glu Pro Cys Leu Ser Cys Ser 
545                 550                 555                 560 


Ser Val Val Gly Ala Gln His Leu Val Ser Ser Xaa Gly Ala Ser Gly 
                565                 570                 575     


Asp Val Gly Ser Pro Gly Phe Gly Leu Pro Gly Leu Pro Gly Arg Ala 
            580                 585                 590         


Gly Val Pro Gly Leu Lys Gly Glu Lys Gly Asn Phe Gly Glu Ala Gly 
        595                 600                 605             


Pro Ala Gly Ser Pro Gly Pro Pro Gly Pro Val Gly Pro Ala Gly Ile 
    610                 615                 620                 


Lys Gly Ala Lys Gly Glu Pro Cys Glu Pro Cys Pro Ala Leu Ser Asn 
625                 630                 635                 640 


Leu Gln Asp Gly Asp Val Arg Val Val Ala Leu Pro Gly Pro Ser Gly 
                645                 650                 655     


Glu Lys Gly Glu Pro Gly Pro Pro Gly Phe Gly Leu Pro Gly Lys Gln 
            660                 665                 670         


Gly Lys Ala Gly Glu Arg Gly Leu Lys Gly Gln Lys Gly Asp Ala Gly 
        675                 680                 685             


Asn Pro Gly Asp Pro Gly Xaa Pro Gly Xaa Xaa Gly Arg Pro Gly Leu 
    690                 695                 700                 


Ser Gly Glu Pro Gly Val Gln Gly Pro Ala Gly Pro Lys Gly Glu Lys 
705                 710                 715                 720 


Gly Asp Gly Cys Xaa Ala Cys Pro Ser Leu Gln Gly Xaa Val Xaa Asp 
                725                 730                 735     


Met Ala Gly Arg Pro Gly Gln Pro Gly Pro Lys Gly Glu Gln Gly Pro 
            740                 745                 750         


Glu Gly Val Gly Arg Pro Gly Lys Pro Gly Gln Pro Gly Leu Pro Gly 
        755                 760                 765             


Val Gln Gly Pro Pro Gly Leu Lys Gly Val Gln Gly Glu Pro Gly Pro 
    770                 775                 780                 


Pro Gly Arg Gly Val Gln Gly Pro Gln Gly Glu Pro Gly Ala Pro Gly 
785                 790                 795                 800 


Leu Pro Gly Ile Gln Gly Leu Pro Gly Pro Arg Gly Pro Pro Gly Pro 
                805                 810                 815     


Xaa Gly Glu Lys Gly Ala Gln Gly Ser Pro Gly Val Lys Gly Ala Xaa 
            820                 825                 830         


Gly Pro Val Gly Pro Pro Gly Ala Ser Val Ser Gly Pro Pro Gly Arg 
        835                 840                 845             


Asp Gly Gln Gln Gly Gln Xaa Gly Leu Arg Gly Xaa Pro Gly Glu Lys 
    850                 855                 860                 


Gly Pro Arg Gly Glu Lys Gly Glu Pro Gly Glu Cys Ser Cys Pro Ser 
865                 870                 875                 880 


Gln Gly Asp Leu Ile Phe Ser Gly Met Pro Gly Ala Pro Gly Leu Trp 
                885                 890                 895     


Met Gly Ser Ser Trp Gln Pro Gly Pro Gln Gly Pro Pro Gly Ile Pro 
            900                 905                 910         


Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Leu Gln Gly Val Pro Gly 
        915                 920                 925             


Asn Asn Gly Leu Pro Gly Gln Pro Gly Leu Xaa Ala Glu Leu Gly Ser 
    930                 935                 940                 


Leu Pro Ile Glu Gln His Leu Leu Lys Ser Ile Cys Gly Asp Cys Val 
945                 950                 955                 960 


Gln Gly Gln Arg Ala His Pro Gly Tyr Leu Val Glu Lys Gly Glu Lys 
                965                 970                 975     


Gly Asp Gln Gly Ile Pro Gly Val Pro Gly Leu Asp Asn Cys Ala Gln 
            980                 985                 990         


Cys Phe Leu Ser Leu Glu Arg Pro  Arg Ala Glu Glu Ala  Arg Gly Asp 
        995                 1000                 1005             


Asn Ser  Glu Gly Asp Pro Gly  Cys Val Gly Ser Pro  Gly Leu Pro 
    1010                 1015                 1020             


Gly Pro  Pro Gly Leu Pro Gly  Gln Arg Gly Glu Glu  Gly Pro Pro 
    1025                 1030                 1035             


Gly Met  Arg Gly Ser Pro Gly  Pro Pro Gly Pro Ile  Gly Pro Pro 
    1040                 1045                 1050             


Gly Phe  Pro Gly Ala Val Gly  Ser Pro Gly Leu Pro  Gly Leu Gln 
    1055                 1060                 1065             


Gly Glu  Arg Gly Leu Xaa Gly  Leu Xaa Gly Asp Lys  Gly Glu Pro 
    1070                 1075                 1080             


Gly Pro  Pro Gly Gln Pro Gly  Tyr Pro Gly Ala Xaa  Gly Pro Pro 
    1085                 1090                 1095             


Gly Leu  Pro Gly Ile Lys Gly  Glu Arg Gly Tyr Xaa  Gly Ser Ala 
    1100                 1105                 1110             


Gly Glu  Lys Gly Glu Pro Gly  Pro Pro Gly Ser Glu  Gly Leu Pro 
    1115                 1120                 1125             


Gly Pro  Pro Gly Pro Ala Gly  Pro Arg Gly Glu Arg  Gly Pro Gln 
    1130                 1135                 1140             


Gly Asn  Ser Gly Glu Lys Gly  Asp Gln Gly Phe Gln  Gly Gln Pro 
    1145                 1150                 1155             


Gly Phe  Pro Gly Pro Pro Gly  Pro Pro Gly Phe Pro  Gly Lys Val 
    1160                 1165                 1170             


Gly Ser  Pro Gly Pro Pro Gly  Pro Gln Ala Glu Lys  Gly Ser Glu 
    1175                 1180                 1185             


Gly Ile  Arg Gly Pro Ser Gly  Leu Pro Gly Ser Pro  Gly Pro Pro 
    1190                 1195                 1200             


Gly Pro  Pro Gly Ile Gln Gly  Pro Ala Gly Leu Asp  Gly Leu Asp 
    1205                 1210                 1215             


Gly Lys  Asp Gly Lys Pro Gly  Leu Arg Gly Asp Pro  Gly Pro Ala 
    1220                 1225                 1230             


Gly Pro  Pro Gly Leu Met Gly  Pro Pro Gly Phe Lys  Gly Lys Xaa 
    1235                 1240                 1245             


Gly His  Pro Gly Leu Pro Gly  Pro Lys Gly Asp Cys  Gly Lys Pro 
    1250                 1255                 1260             


Gly Pro  Pro Gly Ser Xaa Gly  Arg Pro Gly Ala Glu  Gly Glu Pro 
    1265                 1270                 1275             


Gly Ala  Met Gly Pro Gln Gly  Arg Pro Gly Pro Pro  Gly His Val 
    1280                 1285                 1290             


Gly Pro  Pro Gly Pro Pro Gly  Gln Pro Gly Pro Ala  Gly Ile Ser 
    1295                 1300                 1305             


Ala Val  Gly Leu Lys Gly Asp  Arg Gly Ala Xaa Gly  Glu Arg Gly 
    1310                 1315                 1320             


Leu Ala  Gly Leu Pro Gly Gln  Pro Gly Pro Pro Gly  His Pro Gly 
    1325                 1330                 1335             


Pro Pro  Gly Glu Pro Gly Xaa  Asp Gly Ala Ala Gly  Lys Glu Gly 
    1340                 1345                 1350             


Pro Pro  Gly Lys Gln Gly Phe  Tyr Gly Pro Pro Gly  Pro Lys Gly 
    1355                 1360                 1365             


Asp Pro  Gly Ala Ala Gly Gln  Lys Gly Gln Ala Gly  Glu Lys Gly 
    1370                 1375                 1380             


Arg Ala  Gly Met Pro Gly Gly  Pro Gly Lys Ser Gly  Ser Met Gly 
    1385                 1390                 1395             


Pro Val  Gly Pro Pro Gly Pro  Ala Gly Glu Arg Gly  His Pro Gly 
    1400                 1405                 1410             


Ala Pro  Gly Pro Ser Gly Ser  Pro Gly Leu Pro Gly  Val Pro Gly 
    1415                 1420                 1425             


Ser Met  Gly Asp Met Val Asn  Tyr Asp Glu Ile Lys  Arg Phe Ile 
    1430                 1435                 1440             


Arg Gln  Glu Ile Ile Lys Met  Phe Asp Glu Arg Met  Ala Tyr Tyr 
    1445                 1450                 1455             


Xaa Ser  Arg Met Gln Phe Pro  Met Glu Met Ala Ala  Ala Pro Gly 
    1460                 1465                 1470             


Arg Pro  Gly Pro Pro Gly Lys  Asp Gly Ala Pro Gly  Arg Pro Gly 
    1475                 1480                 1485             


Ala Pro  Gly Ser Pro Gly Leu  Pro Gly Gln Ile Gly  Arg Glu Gly 
    1490                 1495                 1500             


Arg Gln  Gly Leu Pro Gly Val  Arg Gly Leu Pro Gly  Xaa Lys Gly 
    1505                 1510                 1515             


Glu Lys  Gly Asp Ile Gly Ile  Gly Ile Ala Gly Glu  Asn Gly Leu 
    1520                 1525                 1530             


Pro Gly  Pro Pro Gly Pro Gln  Gly Pro Pro Gly Tyr  Gly Lys Met 
    1535                 1540                 1545             


Gly Ala  Xaa Gly Pro Met Gly  Gln Gln Gly Ile Pro  Gly Ile Pro 
    1550                 1555                 1560             


Gly Pro  Pro Gly Pro Met Gly  Gln Pro Gly Lys Ala  Gly His Cys 
    1565                 1570                 1575             


Asn Pro  Ser Asp Cys Phe Gly  Ala Met Pro Met Glu  Gln Gln Tyr 
    1580                 1585                 1590             


Pro Pro  Met Lys Xaa Met Lys  Gly Pro Phe Gly 
    1595                 1600                 


<210> 6644
<211> 1464
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1295)..(1295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1298)..(1298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1353)..(1353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1360)..(1360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1367)..(1367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1407)..(1407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1411)..(1411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1416)..(1416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1419)..(1419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1425)..(1425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1431)..(1432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<400> 6644
Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Xaa 
1               5                   10                  15      


Ala Leu Leu Xaa His Gly Gln Glu Glu Gly Gln Val Glu Gly Gln Asp 
            20                  25                  30          


Glu Asp Ile Pro Pro Ile Xaa Cys Val Gln Asn Gly Leu Arg Tyr His 
        35                  40                  45              


Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val Cys Asp 
    50                  55                  60                  


Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Xaa Lys Asn 
65                  70                  75                  80  


Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val Cys Pro 
                85                  90                  95      


Asp Gly Ser Glu Ser Pro Xaa Asp Gln Glu Xaa Xaa Gly Val Glu Gly 
            100                 105                 110         


Pro Lys Gly Asp Xaa Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro 
        115                 120                 125             


Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala 
145                 150                 155                 160 


Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Xaa Gly Gly Ile Ser 
                165                 170                 175     


Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro 
            180                 185                 190         


Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro 
        195                 200                 205             


Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly 
    210                 215                 220                 


Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg 
225                 230                 235                 240 


Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro 
                245                 250                 255     


Gly Xaa Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly 
            260                 265                 270         


Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu 
        275                 280                 285             


Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg 
    290                 295                 300                 


Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly 
305                 310                 315                 320 


Ala Arg Gly Asn Asp Gly Ala Xaa Gly Ala Ala Gly Pro Pro Gly Pro 
                325                 330                 335     


Xaa Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys 
            340                 345                 350         


Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly 
        355                 360                 365             


Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro 
    370                 375                 380                 


Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn 
385                 390                 395                 400 


Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly 
                405                 410                 415     


Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn 
            420                 425                 430         


Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Xaa Gly Ala Lys 
        435                 440                 445             


Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 
    450                 455                 460                 


Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Xaa Gly Leu 
465                 470                 475                 480 


Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro 
                485                 490                 495     


Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly 
            500                 505                 510         


Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg 
        515                 520                 525             


Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Xaa Gly Ser Pro 
    530                 535                 540                 


Gly Ser Pro Gly Pro Asp Gly Lys Xaa Gly Pro Pro Gly Pro Ala Gly 
545                 550                 555                 560 


Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln 
                565                 570                 575     


Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro 
            580                 585                 590         


Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly 
        595                 600                 605             


Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro 
    610                 615                 620                 


Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro 
625                 630                 635                 640 


Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly 
                645                 650                 655     


Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro 
            660                 665                 670         


Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln 
        675                 680                 685             


Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly 
    690                 695                 700                 


Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser 
705                 710                 715                 720 


Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala 
                725                 730                 735     


Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly 
            740                 745                 750         


Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Xaa Gly Pro 
        755                 760                 765             


Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser 
    770                 775                 780                 


Gly Pro Ser Gly Pro Ala Gly Pro Xaa Gly Ala Arg Gly Ala Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro 
                805                 810                 815     


Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala 
            820                 825                 830         


Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly 
        835                 840                 845             


Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala 
    850                 855                 860                 


Arg Gly Ser Ala Gly Pro Pro Gly Ala Xaa Gly Phe Pro Gly Ala Ala 
865                 870                 875                 880 


Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly 
                885                 890                 895     


Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu 
            900                 905                 910         


Xaa Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro 
        915                 920                 925             


Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly 
    930                 935                 940                 


Ala Pro Gly Xaa Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val 
945                 950                 955                 960 


Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro 
                965                 970                 975     


Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly 
            980                 985                 990         


Glu Arg Gly Pro Pro Gly Pro Met  Gly Pro Pro Gly Leu  Ala Gly Pro 
        995                 1000                 1005             


Pro Gly  Glu Ser Gly Arg Glu  Gly Ala Pro Gly Ala  Glu Gly Ser 
    1010                 1015                 1020             


Pro Gly  Arg Asp Gly Ser Pro  Gly Ala Lys Gly Asp  Arg Gly Glu 
    1025                 1030                 1035             


Xaa Gly  Pro Ala Gly Pro Pro  Gly Ala Pro Gly Ala  Pro Gly Ala 
    1040                 1045                 1050             


Pro Gly  Pro Val Gly Pro Ala  Gly Lys Ser Gly Asp  Arg Gly Glu 
    1055                 1060                 1065             


Xaa Gly  Pro Ala Gly Pro Ala  Gly Pro Val Gly Pro  Val Gly Ala 
    1070                 1075                 1080             


Arg Gly  Pro Ala Gly Pro Gln  Gly Pro Arg Gly Asp  Lys Gly Glu 
    1085                 1090                 1095             


Xaa Gly  Glu Gln Gly Asp Arg  Gly Ile Lys Gly His  Arg Gly Phe 
    1100                 1105                 1110             


Ser Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Ser  Pro Gly Glu 
    1115                 1120                 1125             


Gln Gly  Pro Ser Gly Ala Ser  Gly Pro Ala Gly Pro  Arg Gly Pro 
    1130                 1135                 1140             


Pro Gly  Ser Ala Gly Ala Pro  Gly Lys Asp Gly Leu  Asn Gly Leu 
    1145                 1150                 1155             


Pro Gly  Pro Ile Gly Pro Pro  Gly Pro Arg Gly Arg  Xaa Gly Asp 
    1160                 1165                 1170             


Ala Gly  Pro Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1175                 1180                 1185             


Pro Gly  Pro Pro Ser Ala Gly  Phe Asp Phe Ser Phe  Leu Pro Gln 
    1190                 1195                 1200             


Pro Pro  Gln Glu Lys Ala His  Asp Gly Gly Arg Tyr  Tyr Arg Ala 
    1205                 1210                 1215             


Asp Asp  Ala Asn Val Val Arg  Asp Arg Asp Leu Glu  Val Asp Xaa 
    1220                 1225                 1230             


Xaa Leu  Lys Ser Leu Ser Gln  Gln Ile Glu Asn Ile  Arg Ser Pro 
    1235                 1240                 1245             


Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Xaa Cys Arg  Asp Leu Lys 
    1250                 1255                 1260             


Met Cys  His Ser Asp Trp Lys  Ser Gly Glu Tyr Trp  Ile Asp Pro 
    1265                 1270                 1275             


Asn Gln  Gly Cys Asn Leu Asp  Ala Ile Lys Val Phe  Cys Asn Met 
    1280                 1285                 1290             


Glu Xaa  Gly Glu Xaa Cys Val  Tyr Pro Xaa Gln Pro  Ser Val Ala 
    1295                 1300                 1305             


Gln Lys  Asn Trp Tyr Ile Ser  Lys Asn Pro Lys Asp  Lys Arg His 
    1310                 1315                 1320             


Val Trp  Phe Gly Glu Ser Met  Xaa Asp Gly Phe Gln  Phe Glu Tyr 
    1325                 1330                 1335             


Gly Gly  Gln Gly Ser Asp Pro  Ala Asp Val Ala Ile  Gln Leu Xaa 
    1340                 1345                 1350             


Phe Leu  Arg Leu Met Ser Xaa  Glu Ala Ser Gln Asn  Ile Xaa Tyr 
    1355                 1360                 1365             


His Cys  Lys Asn Ser Val Ala  Tyr Met Asp Gln Gln  Xaa Gly Asn 
    1370                 1375                 1380             


Leu Lys  Lys Ala Leu Leu Leu  Gln Gly Ser Asn Glu  Ile Glu Ile 
    1385                 1390                 1395             


Arg Ala  Glu Gly Asn Ser Arg  Phe Xaa Tyr Ser Val  Xaa Val Asp 
    1400                 1405                 1410             


Gly Cys  Xaa Ser His Xaa Gly  Ala Trp Gly Lys Xaa  Val Ile Glu 
    1415                 1420                 1425             


Tyr Lys  Xaa Xaa Lys Xaa Ser  Arg Leu Pro Ile Ile  Asp Val Ala 
    1430                 1435                 1440             


Pro Leu  Asp Val Gly Ala Pro  Asp Gln Glu Phe Gly  Phe Asp Val 
    1445                 1450                 1455             


Gly Pro  Val Cys Phe Leu 
    1460                 


<210> 6645
<211> 154
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<400> 6645
Met Arg Ser Arg Arg Ala Phe Lys Asp Leu Arg Lys Glu Glu Arg Gly 
1               5                   10                  15      


Glu Gly Arg Glu Val Lys Asn Pro Ser Val Pro Leu Arg Pro Gly Gly 
            20                  25                  30          


Lys Val Val Lys Leu Gly Val Ala Val Xaa Xaa Asp Asn Ala Pro Leu 
        35                  40                  45              


Pro Pro Val Pro Val Pro Pro Ile Xaa Cys Val Gln Asn Gly Leu Arg 
    50                  55                  60                  


Tyr His Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val 
65                  70                  75                  80  


Cys Asp Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Xaa 
                85                  90                  95      


Lys Asn Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val 
            100                 105                 110         


Cys Pro Asp Gly Ser Glu Ser Pro Xaa Asp Gln Glu Xaa Xaa Gly Val 
        115                 120                 125             


Glu Gly Pro Lys Gly Asp Xaa Gly Pro Arg Gly Pro Arg Gly Pro Ala 
    130                 135                 140                 


Gly Pro Pro Gly Arg Asp Gly Ile Pro Gly 
145                 150                 


<210> 6646
<211> 1364
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1066)..(1066)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1071)..(1071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1146)..(1146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1160)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1197)..(1197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1200)..(1200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1244)..(1244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1267)..(1267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1281)..(1281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1319)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1325)..(1325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1331)
<223> Selenocysteine

<400> 6646
Met Leu Ser Phe Val Asp Xaa Arg Xaa Leu Leu Leu Leu Ala Val Xaa 
1               5                   10                  15      


Leu Cys Leu Ala Xaa Cys Gln Phe Phe Glu Xaa Val Arg Lys Gly Pro 
            20                  25                  30          


Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly Pro Pro 
        35                  40                  45              


Gly Arg Asp Gly Glu Asp Gly Pro Xaa Gly Pro Pro Gly Pro Pro Gly 
    50                  55                  60                  


Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln Tyr Asp 
65                  70                  75                  80  


Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met Gly Pro 
                85                  90                  95      


Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly Phe Gln 
            100                 105                 110         


Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Xaa Gly Pro Ala Gly 
        115                 120                 125             


Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp Gly His 
    130                 135                 140                 


Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly Pro Gln 
145                 150                 155                 160 


Gly Ala Arg Gly Phe Pro Gly Xaa Pro Gly Leu Pro Gly Phe Lys Gly 
                165                 170                 175     


Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro Gly Ala 
            180                 185                 190         


Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly Xaa Pro 
        195                 200                 205             


Gly Gln Xaa Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg Val Gly 
    210                 215                 220                 


Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val Gly Pro 
225                 230                 235                 240 


Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly Phe Pro 
                245                 250                 255     


Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn Ala Gly 
            260                 265                 270         


Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro Gly Leu 
        275                 280                 285             


Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly Leu Xaa 
    290                 295                 300                 


Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala Pro Gly 
305                 310                 315                 320 


Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala Gly Ala 
                325                 330                 335     


Xaa Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly Ser Lys 
            340                 345                 350         


Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro Gln Gly 
        355                 360                 365             


Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn Gly Glu 
    370                 375                 380                 


Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly Ser Pro 
385                 390                 395                 400 


Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val Met Gly 
                405                 410                 415     


Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg Gly Pro 
            420                 425                 430         


Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly Pro Arg 
        435                 440                 445             


Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys Glu Gly 
    450                 455                 460                 


Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile Gly Pro 
465                 470                 475                 480 


Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly Pro Lys 
                485                 490                 495     


Gly Pro Xaa Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His Ala Gly 
            500                 505                 510         


Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn Gly Ala 
        515                 520                 525             


Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly Glu Gln 
    530                 535                 540                 


Gly Pro Pro Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro Ser Gly 
545                 550                 555                 560 


Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His Gly Glu 
                565                 570                 575     


Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly Pro Pro 
            580                 585                 590         


Gly Glu Ser Gly Ala Ala Gly Pro Xaa Gly Pro Ile Gly Ser Arg Gly 
        595                 600                 605             


Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro Gly Val 
    610                 615                 620                 


Val Gly Ala Val Gly Xaa Ala Gly Pro Ser Gly Pro Ser Gly Leu Pro 
625                 630                 635                 640 


Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu Lys Gly 
                645                 650                 655     


Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp Gly Ala 
            660                 665                 670         


Arg Gly Ala Pro Gly Ala Val Gly Ala Pro Gly Pro Ala Gly Ala Xaa 
        675                 680                 685             


Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro Ala Gly 
    690                 695                 700                 


Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala Gly Pro 
705                 710                 715                 720 


Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly Ala Lys 
                725                 730                 735     


Gly Glu Arg Gly Ala Lys Gly Pro Lys Gly Glu Asn Gly Val Val Gly 
            740                 745                 750         


Pro Xaa Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn Gly Pro 
        755                 760                 765             


Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly Met Xaa 
    770                 775                 780                 


Gly Phe Pro Gly Ala Ala Gly Arg Xaa Gly Pro Pro Gly Pro Ser Gly 
785                 790                 795                 800 


Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu Gly Leu 
                805                 810                 815     


Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Xaa Gly Glu Val 
            820                 825                 830         


Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro Ser Gly 
        835                 840                 845             


Glu Ala Gly Xaa Ala Gly Pro Pro Gly Xaa Pro Gly Pro Gln Gly Leu 
    850                 855                 860                 


Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly Glu Arg 
865                 870                 875                 880 


Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro Leu Gly 
                885                 890                 895     


Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val Gly Ser 
            900                 905                 910         


Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly Asn Pro 
        915                 920                 925             


Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His Lys Gly 
    930                 935                 940                 


Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala Gly Ala 
945                 950                 955                 960 


Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly Asn Arg 
                965                 970                 975     


Gly Glu Xaa Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala Val Gly 
            980                 985                 990         


Pro Arg Gly Pro Ser Gly Pro Gln  Gly Ile Arg Gly Asp  Lys Gly Glu 
        995                 1000                 1005             


Pro Gly  Glu Lys Gly Pro Arg  Gly Leu Pro Gly Leu  Lys Gly His 
    1010                 1015                 1020             


Asn Gly  Leu Gln Gly Leu Pro  Gly Ile Ala Gly His  His Gly Asp 
    1025                 1030                 1035             


Gln Gly  Ala Pro Gly Ser Val  Gly Pro Ala Gly Pro  Arg Gly Pro 
    1040                 1045                 1050             


Ala Gly  Pro Ser Gly Pro Ala  Gly Lys Asp Gly Arg  Xaa Gly His 
    1055                 1060                 1065             


Pro Gly  Xaa Val Gly Pro Ala  Gly Ile Arg Gly Pro  Gln Gly His 
    1070                 1075                 1080             


Gln Gly  Pro Ala Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1085                 1090                 1095             


Pro Gly  Val Ser Gly Gly Gly  Tyr Asp Phe Gly Tyr  Asp Gly Asp 
    1100                 1105                 1110             


Phe Tyr  Arg Ala Asp Gln Pro  Arg Ser Ala Pro Ser  Leu Arg Pro 
    1115                 1120                 1125             


Lys Asp  Tyr Glu Val Asp Ala  Xaa Leu Lys Ser Leu  Asn Asn Gln 
    1130                 1135                 1140             


Ile Glu  Xaa Leu Leu Xaa Pro  Glu Gly Ser Arg Lys  Asn Pro Ala 
    1145                 1150                 1155             


Arg Xaa  Cys Arg Asp Leu Arg  Leu Ser His Pro Glu  Trp Ser Ser 
    1160                 1165                 1170             


Gly Tyr  Tyr Trp Ile Asp Pro  Asn Gln Gly Cys Xaa  Met Asp Ala 
    1175                 1180                 1185             


Ile Lys  Val Tyr Cys Asp Phe  Ser Xaa Gly Glu Xaa  Cys Ile Arg 
    1190                 1195                 1200             


Ala Gln  Pro Glu Asn Ile Pro  Ala Lys Asn Trp Tyr  Arg Ser Ser 
    1205                 1210                 1215             


Lys Asp  Lys Lys His Val Trp  Leu Gly Glu Xaa Ile  Asn Ala Gly 
    1220                 1225                 1230             


Ser Gln  Phe Glu Tyr Asn Val  Glu Gly Val Xaa Ser  Lys Glu Met 
    1235                 1240                 1245             


Ala Xaa  Gln Leu Ala Phe Met  Arg Leu Leu Ala Asn  Tyr Ala Ser 
    1250                 1255                 1260             


Gln Asn  Ile Xaa Tyr His Cys  Lys Asn Ser Ile Ala  Tyr Met Asp 
    1265                 1270                 1275             


Glu Glu  Xaa Gly Asn Leu Lys  Lys Ala Val Ile Leu  Gln Gly Ser 
    1280                 1285                 1290             


Asn Asp  Val Glu Leu Val Ala  Glu Gly Asn Ser Arg  Phe Xaa Tyr 
    1295                 1300                 1305             


Xaa Val  Leu Val Asp Gly Cys  Ser Lys Lys Xaa Asn  Glu Trp Gly 
    1310                 1315                 1320             


Lys Xaa  Ile Ile Glu Tyr Lys  Xaa Asn Lys Pro Ser  Arg Leu Pro 
    1325                 1330                 1335             


Phe Leu  Asp Ile Ala Pro Leu  Asp Ile Gly Gly Ala  Asp Gln Glu 
    1340                 1345                 1350             


Phe Phe  Val Asp Ile Gly Pro  Val Cys Phe Lys 
    1355                 1360                 


<210> 6647
<211> 1366
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (981)..(981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1138)..(1138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1162)..(1162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1187)..(1187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1199)..(1199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1202)..(1202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1246)..(1246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1252)..(1252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1321)..(1321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1327)..(1327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<400> 6647
Met Leu Ser Phe Val Asp Xaa Arg Xaa Leu Leu Leu Leu Ala Val Xaa 
1               5                   10                  15      


Leu Cys Leu Ala Xaa Cys Gln Ser Leu Gln Glu Glu Xaa Val Arg Lys 
            20                  25                  30          


Gly Pro Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly 
        35                  40                  45              


Pro Pro Gly Arg Asp Gly Glu Asp Gly Pro Xaa Gly Pro Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln 
65                  70                  75                  80  


Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met 
                85                  90                  95      


Gly Pro Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly 
            100                 105                 110         


Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Xaa Gly Pro 
        115                 120                 125             


Ala Gly Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp 
    130                 135                 140                 


Gly His Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly 
145                 150                 155                 160 


Pro Gln Gly Ala Arg Gly Phe Pro Gly Xaa Pro Gly Leu Pro Gly Phe 
                165                 170                 175     


Lys Gly Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro 
            180                 185                 190         


Gly Ala Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly 
        195                 200                 205             


Xaa Pro Gly Gln Xaa Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg 
    210                 215                 220                 


Val Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val 
225                 230                 235                 240 


Gly Pro Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly 
                245                 250                 255     


Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn 
            260                 265                 270         


Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro 
        275                 280                 285             


Gly Leu Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly 
    290                 295                 300                 


Leu Xaa Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala 
                325                 330                 335     


Gly Ala Xaa Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly 
            340                 345                 350         


Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro 
        355                 360                 365             


Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn 
    370                 375                 380                 


Gly Glu Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly 
385                 390                 395                 400 


Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val 
                405                 410                 415     


Met Gly Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg 
            420                 425                 430         


Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly 
        435                 440                 445             


Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys 
    450                 455                 460                 


Glu Gly Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile 
465                 470                 475                 480 


Gly Pro Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly 
                485                 490                 495     


Pro Lys Gly Pro Xaa Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His 
            500                 505                 510         


Ala Gly Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn 
        515                 520                 525             


Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly 
    530                 535                 540                 


Glu Gln Gly Pro Pro Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro 
545                 550                 555                 560 


Ser Gly Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His 
                565                 570                 575     


Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly 
            580                 585                 590         


Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro Xaa Gly Pro Ile Gly Ser 
        595                 600                 605             


Arg Gly Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro 
    610                 615                 620                 


Gly Val Val Gly Ala Val Gly Xaa Ala Gly Pro Ser Gly Pro Ser Gly 
625                 630                 635                 640 


Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu 
                645                 650                 655     


Lys Gly Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp 
            660                 665                 670         


Gly Ala Arg Gly Ala Pro Gly Ala Val Gly Ala Pro Gly Pro Ala Gly 
        675                 680                 685             


Ala Xaa Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro 
    690                 695                 700                 


Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala 
705                 710                 715                 720 


Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly 
                725                 730                 735     


Ala Lys Gly Glu Arg Gly Ala Lys Gly Pro Lys Gly Glu Asn Gly Val 
            740                 745                 750         


Val Gly Pro Xaa Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn 
        755                 760                 765             


Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly 
    770                 775                 780                 


Met Xaa Gly Phe Pro Gly Ala Ala Gly Arg Xaa Gly Pro Pro Gly Pro 
785                 790                 795                 800 


Ser Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu 
                805                 810                 815     


Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Xaa Gly 
            820                 825                 830         


Glu Val Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro 
        835                 840                 845             


Ser Gly Glu Ala Gly Xaa Ala Gly Pro Pro Gly Xaa Pro Gly Pro Gln 
    850                 855                 860                 


Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly 
865                 870                 875                 880 


Glu Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro 
                885                 890                 895     


Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val 
            900                 905                 910         


Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly 
        915                 920                 925             


Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His 
    930                 935                 940                 


Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala 
945                 950                 955                 960 


Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly 
                965                 970                 975     


Asn Arg Gly Glu Xaa Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala 
            980                 985                 990         


Val Gly Pro Arg Gly Pro Ser Gly  Pro Gln Gly Ile Arg  Gly Asp Lys 
        995                 1000                 1005             


Gly Glu  Pro Gly Glu Lys Gly  Pro Arg Gly Leu Pro  Gly Leu Lys 
    1010                 1015                 1020             


Gly His  Asn Gly Leu Gln Gly  Leu Pro Gly Ile Ala  Gly His His 
    1025                 1030                 1035             


Gly Asp  Gln Gly Ala Pro Gly  Ser Val Gly Pro Ala  Gly Pro Arg 
    1040                 1045                 1050             


Gly Pro  Ala Gly Pro Ser Gly  Pro Ala Gly Lys Asp  Gly Arg Xaa 
    1055                 1060                 1065             


Gly His  Pro Gly Xaa Val Gly  Pro Ala Gly Ile Arg  Gly Pro Gln 
    1070                 1075                 1080             


Gly His  Gln Gly Pro Ala Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1085                 1090                 1095             


Gly Pro  Pro Gly Val Ser Gly  Gly Gly Tyr Asp Phe  Gly Tyr Asp 
    1100                 1105                 1110             


Gly Asp  Phe Tyr Arg Ala Asp  Gln Pro Arg Ser Ala  Pro Ser Leu 
    1115                 1120                 1125             


Arg Pro  Lys Asp Tyr Glu Val  Asp Ala Xaa Leu Lys  Ser Leu Asn 
    1130                 1135                 1140             


Asn Gln  Ile Glu Xaa Leu Leu  Xaa Pro Glu Gly Ser  Arg Lys Asn 
    1145                 1150                 1155             


Pro Ala  Arg Xaa Cys Arg Asp  Leu Arg Leu Ser His  Pro Glu Trp 
    1160                 1165                 1170             


Ser Ser  Gly Tyr Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Xaa Met 
    1175                 1180                 1185             


Asp Ala  Ile Lys Val Tyr Cys  Asp Phe Ser Xaa Gly  Glu Xaa Cys 
    1190                 1195                 1200             


Ile Arg  Ala Gln Pro Glu Asn  Ile Pro Ala Lys Asn  Trp Tyr Arg 
    1205                 1210                 1215             


Ser Ser  Lys Asp Lys Lys His  Val Trp Leu Gly Glu  Xaa Ile Asn 
    1220                 1225                 1230             


Ala Gly  Ser Gln Phe Glu Tyr  Asn Val Glu Gly Val  Xaa Ser Lys 
    1235                 1240                 1245             


Glu Met  Ala Xaa Gln Leu Ala  Phe Met Arg Leu Leu  Ala Asn Tyr 
    1250                 1255                 1260             


Ala Ser  Gln Asn Ile Xaa Tyr  His Cys Lys Asn Ser  Ile Ala Tyr 
    1265                 1270                 1275             


Met Asp  Glu Glu Xaa Gly Asn  Leu Lys Lys Ala Val  Ile Leu Gln 
    1280                 1285                 1290             


Gly Ser  Asn Asp Val Glu Leu  Val Ala Glu Gly Asn  Ser Arg Phe 
    1295                 1300                 1305             


Xaa Tyr  Xaa Val Leu Val Asp  Gly Cys Ser Lys Lys  Xaa Asn Glu 
    1310                 1315                 1320             


Trp Gly  Lys Xaa Ile Ile Glu  Tyr Lys Xaa Asn Lys  Pro Ser Arg 
    1325                 1330                 1335             


Leu Pro  Phe Leu Asp Ile Ala  Pro Leu Asp Ile Gly  Gly Ala Asp 
    1340                 1345                 1350             


Gln Glu  Phe Phe Val Asp Ile  Gly Pro Val Cys Phe  Lys 
    1355                 1360                 1365     


<210> 6648
<211> 1487
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1258)..(1258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1282)..(1282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1319)..(1319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1322)..(1322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1376)..(1376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1383)..(1383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1390)..(1390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1430)..(1430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1432)..(1432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1439)..(1439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1442)..(1442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1448)..(1448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1457)..(1457)
<223> Selenocysteine

<400> 6648
Met Ile Arg Leu Gly Ala Pro Gln Xaa Leu Val Leu Leu Xaa Leu Leu 
1               5                   10                  15      


Val Ala Ala Val Leu Arg Cys Gln Gly Gln Asp Val Gln Glu Ala Gly 
            20                  25                  30          


Ser Cys Val Gln Asp Gly Gln Arg Tyr Asn Asp Lys Asp Val Trp Lys 
        35                  40                  45              


Pro Glu Pro Cys Arg Ile Cys Val Cys Asp Xaa Gly Xaa Val Leu Cys 
    50                  55                  60                  


Asp Asp Ile Ile Cys Glu Asp Val Lys Asp Cys Leu Ser Pro Glu Ile 
65                  70                  75                  80  


Pro Phe Gly Glu Cys Cys Pro Ile Cys Pro Xaa Asp Leu Ala Xaa Ala 
                85                  90                  95      


Ser Gly Gln Pro Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Asp Ile 
            100                 105                 110         


Lys Asp Ile Val Gly Pro Lys Gly Pro Pro Gly Pro Gln Gly Pro Ala 
        115                 120                 125             


Gly Glu Gln Gly Pro Arg Gly Asp Arg Gly Asp Lys Gly Glu Lys Gly 
    130                 135                 140                 


Ala Pro Gly Pro Arg Gly Arg Asp Gly Glu Pro Gly Xaa Pro Gly Asn 
145                 150                 155                 160 


Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly 
                165                 170                 175     


Gly Asn Phe Ala Ala Gln Met Ala Gly Gly Phe Asp Glu Lys Ala Gly 
            180                 185                 190         


Gly Ala Gln Leu Gly Val Met Gln Gly Pro Met Gly Pro Met Gly Pro 
        195                 200                 205             


Arg Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Gln Gly Phe Gln 
    210                 215                 220                 


Gly Asn Pro Gly Glu Pro Gly Glu Pro Gly Val Ser Gly Pro Met Gly 
225                 230                 235                 240 


Pro Arg Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly Asp Asp Gly Glu 
                245                 250                 255     


Ala Gly Lys Pro Gly Lys Ala Gly Glu Arg Gly Pro Pro Gly Pro Gln 
            260                 265                 270         


Gly Ala Arg Gly Phe Pro Gly Xaa Pro Gly Leu Pro Gly Val Lys Gly 
        275                 280                 285             


His Arg Gly Tyr Pro Gly Leu Asp Gly Ala Lys Gly Glu Ala Gly Ala 
    290                 295                 300                 


Pro Gly Val Lys Gly Glu Ser Gly Ser Pro Gly Glu Asn Gly Ser Pro 
305                 310                 315                 320 


Gly Pro Met Gly Pro Arg Gly Leu Pro Gly Glu Arg Gly Arg Xaa Gly 
                325                 330                 335     


Pro Ala Gly Ala Ala Gly Ala Arg Gly Asn Asp Gly Gln Pro Gly Pro 
            340                 345                 350         


Ala Gly Pro Pro Gly Pro Val Gly Pro Ala Gly Gly Pro Gly Phe Pro 
        355                 360                 365             


Gly Ala Pro Gly Ala Lys Gly Glu Ala Gly Pro Xaa Gly Ala Arg Gly 
    370                 375                 380                 


Pro Glu Gly Ala Gln Gly Pro Arg Gly Glu Pro Gly Xaa Pro Gly Ser 
385                 390                 395                 400 


Pro Gly Pro Ala Gly Ala Ser Gly Asn Pro Gly Xaa Asp Gly Ile Pro 
                405                 410                 415     


Gly Ala Lys Gly Ser Ala Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly 
            420                 425                 430         


Phe Pro Gly Pro Arg Gly Pro Pro Gly Pro Gln Gly Ala Xaa Gly Pro 
        435                 440                 445             


Leu Gly Pro Lys Gly Gln Xaa Gly Glu Pro Gly Ile Ala Gly Phe Lys 
    450                 455                 460                 


Gly Glu Gln Gly Pro Lys Gly Glu Pro Gly Pro Ala Gly Pro Gln Gly 
465                 470                 475                 480 


Ala Pro Gly Pro Ala Gly Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu 
                485                 490                 495     


Pro Gly Gly Val Gly Pro Ile Gly Pro Pro Gly Glu Arg Gly Ala Pro 
            500                 505                 510         


Gly Asn Arg Gly Phe Pro Gly Gln Asp Gly Leu Ala Gly Pro Lys Gly 
        515                 520                 525             


Ala Pro Gly Glu Arg Gly Pro Ser Gly Leu Ala Gly Pro Lys Gly Ala 
    530                 535                 540                 


Asn Gly Asp Pro Gly Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg 
545                 550                 555                 560 


Gly Leu Xaa Gly Arg Pro Gly Asp Ala Gly Pro Gln Gly Lys Val Gly 
                565                 570                 575     


Pro Ser Gly Ala Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Pro 
            580                 585                 590         


Gln Gly Ala Arg Gly Gln Pro Gly Val Met Gly Phe Pro Gly Pro Lys 
        595                 600                 605             


Gly Ala Asn Gly Glu Pro Gly Lys Ala Gly Glu Lys Gly Leu Pro Gly 
    610                 615                 620                 


Ala Pro Gly Leu Arg Gly Leu Pro Gly Lys Asp Gly Glu Xaa Gly Ala 
625                 630                 635                 640 


Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln 
                645                 650                 655     


Gly Ala Pro Gly Pro Ser Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly 
            660                 665                 670         


Pro Pro Gly Glu Gly Gly Lys Pro Gly Asp Gln Gly Val Pro Gly Glu 
        675                 680                 685             


Ala Gly Ala Pro Gly Leu Val Gly Pro Arg Gly Glu Arg Gly Phe Pro 
    690                 695                 700                 


Gly Glu Arg Gly Ser Pro Gly Ala Gln Gly Leu Gln Gly Pro Arg Gly 
705                 710                 715                 720 


Leu Pro Gly Xaa Pro Gly Xaa Asp Gly Pro Lys Gly Ala Ser Gly Pro 
                725                 730                 735     


Ala Gly Pro Pro Gly Ala Gln Gly Pro Pro Gly Leu Gln Gly Met Pro 
            740                 745                 750         


Gly Glu Arg Gly Ala Ala Gly Ile Ala Gly Pro Lys Gly Asp Arg Gly 
        755                 760                 765             


Asp Val Gly Glu Lys Gly Pro Glu Gly Ala Pro Gly Lys Asp Gly Gly 
    770                 775                 780                 


Arg Gly Leu Xaa Gly Pro Ile Gly Pro Pro Gly Pro Ala Gly Ala Asn 
785                 790                 795                 800 


Gly Glu Lys Gly Glu Val Gly Pro Pro Gly Pro Ala Gly Ser Ala Gly 
                805                 810                 815     


Ala Arg Gly Ala Pro Gly Glu Arg Gly Glu Xaa Gly Pro Pro Gly Pro 
            820                 825                 830         


Ala Gly Phe Ala Gly Pro Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys 
        835                 840                 845             


Gly Glu Gln Gly Glu Ala Gly Gln Lys Gly Asp Ala Gly Ala Pro Gly 
    850                 855                 860                 


Pro Gln Gly Pro Ser Gly Ala Pro Gly Pro Gln Gly Pro Xaa Gly Val 
865                 870                 875                 880 


Xaa Gly Pro Lys Gly Ala Arg Gly Ala Gln Gly Pro Pro Gly Ala Xaa 
                885                 890                 895     


Gly Phe Pro Gly Ala Ala Gly Arg Val Gly Pro Pro Gly Ser Asn Gly 
            900                 905                 910         


Asn Pro Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Lys Asp Gly Pro 
        915                 920                 925             


Lys Gly Ala Arg Gly Asp Ser Gly Pro Pro Gly Arg Ala Gly Glu Pro 
    930                 935                 940                 


Gly Leu Gln Gly Pro Ala Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly 
945                 950                 955                 960 


Asp Asp Gly Pro Ser Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly Leu 
                965                 970                 975     


Ala Gly Gln Arg Gly Ile Val Gly Leu Pro Gly Gln Arg Gly Glu Arg 
            980                 985                 990         


Gly Phe Pro Gly Leu Pro Gly Pro  Ser Gly Glu Pro Gly  Lys Gln Gly 
        995                 1000                 1005             


Ala Pro  Gly Ala Ser Gly Asp  Arg Gly Pro Pro Gly  Pro Val Gly 
    1010                 1015                 1020             


Pro Pro  Gly Leu Xaa Gly Pro  Ala Gly Glu Pro Gly  Arg Glu Gly 
    1025                 1030                 1035             


Ser Pro  Gly Ala Asp Gly Pro  Pro Gly Arg Asp Gly  Ala Ala Gly 
    1040                 1045                 1050             


Val Lys  Gly Asp Arg Gly Glu  Xaa Gly Ala Val Gly  Ala Pro Gly 
    1055                 1060                 1065             


Ala Pro  Gly Pro Pro Gly Ser  Pro Gly Pro Ala Gly  Pro Xaa Gly 
    1070                 1075                 1080             


Lys Gln  Gly Asp Arg Gly Glu  Ala Gly Ala Gln Gly  Pro Met Gly 
    1085                 1090                 1095             


Pro Ser  Gly Pro Ala Gly Ala  Arg Gly Ile Gln Gly  Pro Gln Gly 
    1100                 1105                 1110             


Pro Arg  Gly Asp Lys Gly Glu  Ala Gly Glu Pro Gly  Glu Arg Gly 
    1115                 1120                 1125             


Leu Lys  Gly His Arg Gly Phe  Xaa Gly Leu Gln Gly  Leu Pro Gly 
    1130                 1135                 1140             


Pro Pro  Gly Pro Ser Gly Asp  Gln Gly Ala Ser Gly  Pro Ala Gly 
    1145                 1150                 1155             


Pro Ser  Gly Pro Arg Gly Pro  Pro Gly Pro Val Gly  Pro Ser Gly 
    1160                 1165                 1170             


Lys Asp  Gly Ala Asn Gly Ile  Pro Gly Pro Ile Gly  Pro Pro Gly 
    1175                 1180                 1185             


Pro Arg  Gly Arg Ser Gly Glu  Xaa Gly Pro Ala Gly  Pro Pro Gly 
    1190                 1195                 1200             


Asn Pro  Gly Pro Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Gly Ile 
    1205                 1210                 1215             


Asp Met  Ser Ala Phe Ala Gly  Leu Gly Pro Arg Glu  Lys Gly Pro 
    1220                 1225                 1230             


Asp Pro  Leu Gln Tyr Met Arg  Ala Asp Gln Ala Ala  Gly Gly Leu 
    1235                 1240                 1245             


Arg Gln  His Asp Ala Glu Val  Asp Ala Xaa Leu Lys  Ser Leu Asn 
    1250                 1255                 1260             


Asn Gln  Ile Glu Ser Ile Arg  Ser Pro Glu Gly Ser  Arg Lys Asn 
    1265                 1270                 1275             


Pro Ala  Arg Xaa Cys Arg Asp  Leu Lys Leu Cys His  Pro Glu Trp 
    1280                 1285                 1290             


Lys Ser  Gly Asp Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Xaa Leu 
    1295                 1300                 1305             


Asp Ala  Met Lys Val Phe Cys  Asn Met Glu Xaa Gly  Glu Xaa Cys 
    1310                 1315                 1320             


Val Tyr  Pro Asn Pro Ala Asn  Val Pro Lys Lys Asn  Trp Trp Ser 
    1325                 1330                 1335             


Ser Lys  Ser Lys Glu Lys Lys  His Ile Trp Phe Gly  Glu Xaa Ile 
    1340                 1345                 1350             


Asn Gly  Gly Phe His Phe Ser  Tyr Gly Asp Asp Asn  Leu Ala Pro 
    1355                 1360                 1365             


Asn Xaa  Ala Asn Val Gln Met  Xaa Phe Leu Arg Leu  Leu Ser Xaa 
    1370                 1375                 1380             


Glu Gly  Ser Gln Asn Ile Xaa  Tyr His Cys Lys Asn  Ser Ile Ala 
    1385                 1390                 1395             


Tyr Leu  Asp Glu Ala Ala Gly  Asn Leu Lys Lys Ala  Leu Leu Ile 
    1400                 1405                 1410             


Gln Gly  Ser Asn Asp Val Glu  Ile Arg Ala Glu Gly  Asn Ser Arg 
    1415                 1420                 1425             


Phe Xaa  Tyr Xaa Ala Leu Lys  Asp Gly Cys Xaa Lys  His Xaa Gly 
    1430                 1435                 1440             


Lys Trp  Gly Lys Xaa Val Ile  Glu Tyr Arg Ser Gln  Lys Xaa Ser 
    1445                 1450                 1455             


Arg Leu  Pro Ile Ile Asp Ile  Ala Pro Met Asp Ile  Gly Gly Pro 
    1460                 1465                 1470             


Glu Gln  Glu Phe Gly Val Asp  Ile Gly Pro Val Cys  Phe Leu 
    1475                 1480                 1485         


<210> 6649
<211> 1418
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1189)..(1189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1213)..(1213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1238)..(1238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1253)..(1253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1314)..(1314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1321)..(1321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1361)..(1361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1363)..(1363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1379)..(1379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1388)..(1388)
<223> Selenocysteine

<400> 6649
Met Ile Arg Leu Gly Ala Pro Gln Xaa Leu Val Leu Leu Xaa Leu Leu 
1               5                   10                  15      


Val Ala Ala Val Leu Arg Cys Gln Gly Gln Asp Val Arg Gln Pro Gly 
            20                  25                  30          


Pro Lys Gly Gln Lys Gly Glu Pro Gly Asp Ile Lys Asp Ile Val Gly 
        35                  40                  45              


Pro Lys Gly Pro Pro Gly Pro Gln Gly Pro Ala Gly Glu Gln Gly Pro 
    50                  55                  60                  


Arg Gly Asp Arg Gly Asp Lys Gly Glu Lys Gly Ala Pro Gly Pro Arg 
65                  70                  75                  80  


Gly Arg Asp Gly Glu Pro Gly Xaa Pro Gly Asn Pro Gly Pro Pro Gly 
                85                  90                  95      


Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala 
            100                 105                 110         


Gln Met Ala Gly Gly Phe Asp Glu Lys Ala Gly Gly Ala Gln Leu Gly 
        115                 120                 125             


Val Met Gln Gly Pro Met Gly Pro Met Gly Pro Arg Gly Pro Pro Gly 
    130                 135                 140                 


Pro Ala Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Asn Pro Gly Glu 
145                 150                 155                 160 


Pro Gly Glu Pro Gly Val Ser Gly Pro Met Gly Pro Arg Gly Pro Pro 
                165                 170                 175     


Gly Pro Pro Gly Lys Pro Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly 
            180                 185                 190         


Lys Ala Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Phe 
        195                 200                 205             


Pro Gly Xaa Pro Gly Leu Pro Gly Val Lys Gly His Arg Gly Tyr Pro 
    210                 215                 220                 


Gly Leu Asp Gly Ala Lys Gly Glu Ala Gly Ala Pro Gly Val Lys Gly 
225                 230                 235                 240 


Glu Ser Gly Ser Pro Gly Glu Asn Gly Ser Pro Gly Pro Met Gly Pro 
                245                 250                 255     


Arg Gly Leu Pro Gly Glu Arg Gly Arg Xaa Gly Pro Ala Gly Ala Ala 
            260                 265                 270         


Gly Ala Arg Gly Asn Asp Gly Gln Pro Gly Pro Ala Gly Pro Pro Gly 
        275                 280                 285             


Pro Val Gly Pro Ala Gly Gly Pro Gly Phe Pro Gly Ala Pro Gly Ala 
    290                 295                 300                 


Lys Gly Glu Ala Gly Pro Xaa Gly Ala Arg Gly Pro Glu Gly Ala Gln 
305                 310                 315                 320 


Gly Pro Arg Gly Glu Pro Gly Xaa Pro Gly Ser Pro Gly Pro Ala Gly 
                325                 330                 335     


Ala Ser Gly Asn Pro Gly Xaa Asp Gly Ile Pro Gly Ala Lys Gly Ser 
            340                 345                 350         


Ala Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Pro Arg 
        355                 360                 365             


Gly Pro Pro Gly Pro Gln Gly Ala Xaa Gly Pro Leu Gly Pro Lys Gly 
    370                 375                 380                 


Gln Xaa Gly Glu Pro Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro 
385                 390                 395                 400 


Lys Gly Glu Pro Gly Pro Ala Gly Pro Gln Gly Ala Pro Gly Pro Ala 
                405                 410                 415     


Gly Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Gly Val Gly 
            420                 425                 430         


Pro Ile Gly Pro Pro Gly Glu Arg Gly Ala Pro Gly Asn Arg Gly Phe 
        435                 440                 445             


Pro Gly Gln Asp Gly Leu Ala Gly Pro Lys Gly Ala Pro Gly Glu Arg 
    450                 455                 460                 


Gly Pro Ser Gly Leu Ala Gly Pro Lys Gly Ala Asn Gly Asp Pro Gly 
465                 470                 475                 480 


Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg Gly Leu Xaa Gly Arg 
                485                 490                 495     


Pro Gly Asp Ala Gly Pro Gln Gly Lys Val Gly Pro Ser Gly Ala Pro 
            500                 505                 510         


Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly 
        515                 520                 525             


Gln Pro Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Asn Gly Glu 
    530                 535                 540                 


Pro Gly Lys Ala Gly Glu Lys Gly Leu Pro Gly Ala Pro Gly Leu Arg 
545                 550                 555                 560 


Gly Leu Pro Gly Lys Asp Gly Glu Xaa Gly Ala Ala Gly Pro Pro Gly 
                565                 570                 575     


Pro Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Ala Pro Gly Pro 
            580                 585                 590         


Ser Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Glu Gly 
        595                 600                 605             


Gly Lys Pro Gly Asp Gln Gly Val Pro Gly Glu Ala Gly Ala Pro Gly 
    610                 615                 620                 


Leu Val Gly Pro Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Ser 
625                 630                 635                 640 


Pro Gly Ala Gln Gly Leu Gln Gly Pro Arg Gly Leu Pro Gly Xaa Pro 
                645                 650                 655     


Gly Xaa Asp Gly Pro Lys Gly Ala Ser Gly Pro Ala Gly Pro Pro Gly 
            660                 665                 670         


Ala Gln Gly Pro Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala 
        675                 680                 685             


Ala Gly Ile Ala Gly Pro Lys Gly Asp Arg Gly Asp Val Gly Glu Lys 
    690                 695                 700                 


Gly Pro Glu Gly Ala Pro Gly Lys Asp Gly Gly Arg Gly Leu Xaa Gly 
705                 710                 715                 720 


Pro Ile Gly Pro Pro Gly Pro Ala Gly Ala Asn Gly Glu Lys Gly Glu 
                725                 730                 735     


Val Gly Pro Pro Gly Pro Ala Gly Ser Ala Gly Ala Arg Gly Ala Pro 
            740                 745                 750         


Gly Glu Arg Gly Glu Xaa Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly 
        755                 760                 765             


Pro Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Gln Gly Glu 
    770                 775                 780                 


Ala Gly Gln Lys Gly Asp Ala Gly Ala Pro Gly Pro Gln Gly Pro Ser 
785                 790                 795                 800 


Gly Ala Pro Gly Pro Gln Gly Pro Xaa Gly Val Xaa Gly Pro Lys Gly 
                805                 810                 815     


Ala Arg Gly Ala Gln Gly Pro Pro Gly Ala Xaa Gly Phe Pro Gly Ala 
            820                 825                 830         


Ala Gly Arg Val Gly Pro Pro Gly Ser Asn Gly Asn Pro Gly Pro Pro 
        835                 840                 845             


Gly Pro Pro Gly Pro Ser Gly Lys Asp Gly Pro Lys Gly Ala Arg Gly 
    850                 855                 860                 


Asp Ser Gly Pro Pro Gly Arg Ala Gly Glu Pro Gly Leu Gln Gly Pro 
865                 870                 875                 880 


Ala Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly Asp Asp Gly Pro Ser 
                885                 890                 895     


Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly Leu Ala Gly Gln Arg Gly 
            900                 905                 910         


Ile Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu 
        915                 920                 925             


Pro Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Ala Pro Gly Ala Ser 
    930                 935                 940                 


Gly Asp Arg Gly Pro Pro Gly Pro Val Gly Pro Pro Gly Leu Xaa Gly 
945                 950                 955                 960 


Pro Ala Gly Glu Pro Gly Arg Glu Gly Ser Pro Gly Ala Asp Gly Pro 
                965                 970                 975     


Pro Gly Arg Asp Gly Ala Ala Gly Val Lys Gly Asp Arg Gly Glu Xaa 
            980                 985                 990         


Gly Ala Val Gly Ala Pro Gly Ala  Pro Gly Pro Pro Gly  Ser Pro Gly 
        995                 1000                 1005             


Pro Ala  Gly Pro Xaa Gly Lys  Gln Gly Asp Arg Gly  Glu Ala Gly 
    1010                 1015                 1020             


Ala Gln  Gly Pro Met Gly Pro  Ser Gly Pro Ala Gly  Ala Arg Gly 
    1025                 1030                 1035             


Ile Gln  Gly Pro Gln Gly Pro  Arg Gly Asp Lys Gly  Glu Ala Gly 
    1040                 1045                 1050             


Glu Pro  Gly Glu Arg Gly Leu  Lys Gly His Arg Gly  Phe Xaa Gly 
    1055                 1060                 1065             


Leu Gln  Gly Leu Pro Gly Pro  Pro Gly Pro Ser Gly  Asp Gln Gly 
    1070                 1075                 1080             


Ala Ser  Gly Pro Ala Gly Pro  Ser Gly Pro Arg Gly  Pro Pro Gly 
    1085                 1090                 1095             


Pro Val  Gly Pro Ser Gly Lys  Asp Gly Ala Asn Gly  Ile Pro Gly 
    1100                 1105                 1110             


Pro Ile  Gly Pro Pro Gly Pro  Arg Gly Arg Ser Gly  Glu Xaa Gly 
    1115                 1120                 1125             


Pro Ala  Gly Pro Pro Gly Asn  Pro Gly Pro Pro Gly  Pro Pro Gly 
    1130                 1135                 1140             


Pro Pro  Gly Pro Gly Ile Asp  Met Ser Ala Phe Ala  Gly Leu Gly 
    1145                 1150                 1155             


Pro Arg  Glu Lys Gly Pro Asp  Pro Leu Gln Tyr Met  Arg Ala Asp 
    1160                 1165                 1170             


Gln Ala  Ala Gly Gly Leu Arg  Gln His Asp Ala Glu  Val Asp Ala 
    1175                 1180                 1185             


Xaa Leu  Lys Ser Leu Asn Asn  Gln Ile Glu Ser Ile  Arg Ser Pro 
    1190                 1195                 1200             


Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Xaa Cys Arg  Asp Leu Lys 
    1205                 1210                 1215             


Leu Cys  His Pro Glu Trp Lys  Ser Gly Asp Tyr Trp  Ile Asp Pro 
    1220                 1225                 1230             


Asn Gln  Gly Cys Xaa Leu Asp  Ala Met Lys Val Phe  Cys Asn Met 
    1235                 1240                 1245             


Glu Xaa  Gly Glu Xaa Cys Val  Tyr Pro Asn Pro Ala  Asn Val Pro 
    1250                 1255                 1260             


Lys Lys  Asn Trp Trp Ser Ser  Lys Ser Lys Glu Lys  Lys His Ile 
    1265                 1270                 1275             


Trp Phe  Gly Glu Xaa Ile Asn  Gly Gly Phe His Phe  Ser Tyr Gly 
    1280                 1285                 1290             


Asp Asp  Asn Leu Ala Pro Asn  Xaa Ala Asn Val Gln  Met Xaa Phe 
    1295                 1300                 1305             


Leu Arg  Leu Leu Ser Xaa Glu  Gly Ser Gln Asn Ile  Xaa Tyr His 
    1310                 1315                 1320             


Cys Lys  Asn Ser Ile Ala Tyr  Leu Asp Glu Ala Ala  Gly Asn Leu 
    1325                 1330                 1335             


Lys Lys  Ala Leu Leu Ile Gln  Gly Ser Asn Asp Val  Glu Ile Arg 
    1340                 1345                 1350             


Ala Glu  Gly Asn Ser Arg Phe  Xaa Tyr Xaa Ala Leu  Lys Asp Gly 
    1355                 1360                 1365             


Cys Xaa  Lys His Xaa Gly Lys  Trp Gly Lys Xaa Val  Ile Glu Tyr 
    1370                 1375                 1380             


Arg Ser  Gln Lys Xaa Ser Arg  Leu Pro Ile Ile Asp  Ile Ala Pro 
    1385                 1390                 1395             


Met Asp  Ile Gly Gly Pro Glu  Gln Glu Phe Gly Val  Asp Ile Gly 
    1400                 1405                 1410             


Pro Val  Cys Phe Leu 
    1415             


<210> 6650
<211> 1163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (850)..(850)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1066)..(1066)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1106)..(1106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1108)..(1108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<400> 6650
Met Met Ser Phe Val Gln Lys Gly Ser Trp Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


His Pro Xaa Ile Ile Leu Ala Gln Gln Glu Ala Val Glu Gly Gly Cys 
            20                  25                  30          


Ser His Leu Gly Gln Ser Tyr Ala Asp Arg Asp Val Trp Lys Pro Glu 
        35                  40                  45              


Pro Cys Gln Ile Cys Val Cys Asp Ser Gly Ser Val Leu Cys Asp Asp 
    50                  55                  60                  


Ile Ile Cys Asp Asp Gln Glu Leu Asp Cys Pro Asn Pro Glu Ile Pro 
65                  70                  75                  80  


Phe Gly Glu Cys Cys Ala Val Cys Pro Gln Pro Pro Xaa Ala Pro Xaa 
                85                  90                  95      


Arg Pro Pro Asn Gly Gln Gly Pro Gln Gly Pro Lys Gly Asp Pro Gly 
            100                 105                 110         


Pro Pro Gly Ile Pro Gly Arg Asn Gly Asp Pro Gly Ile Pro Gly Gln 
        115                 120                 125             


Pro Gly Ser Pro Gly Ser Pro Gly Pro Pro Gly Ile Cys Glu Ser Cys 
    130                 135                 140                 


Pro Xaa Gly Pro Gln Asn Tyr Ser Pro Gln Tyr Asp Ser Tyr Asp Val 
145                 150                 155                 160 


Lys Ser Gly Val Ala Val Gly Gly Leu Ala Gly Tyr Pro Gly Pro Ala 
                165                 170                 175     


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Xaa Ser Gly His Pro Gly 
            180                 185                 190         


Ser Pro Gly Ser Pro Gly Tyr Gln Gly Pro Pro Gly Glu Pro Gly Gln 
        195                 200                 205             


Ala Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Ala Ile Gly Pro Ser 
    210                 215                 220                 


Gly Pro Ala Gly Lys Asp Gly Glu Ser Gly Arg Pro Gly Arg Pro Gly 
225                 230                 235                 240 


Glu Arg Gly Leu Pro Gly Pro Pro Gly Ile Lys Gly Pro Ala Gly Ile 
                245                 250                 255     


Pro Gly Phe Pro Gly Met Lys Gly His Arg Gly Phe Asp Gly Arg Asn 
            260                 265                 270         


Gly Glu Lys Gly Glu Xaa Gly Ala Pro Gly Leu Lys Gly Glu Asn Gly 
        275                 280                 285             


Leu Pro Gly Glu Asn Gly Ala Pro Gly Pro Met Gly Pro Arg Gly Ala 
    290                 295                 300                 


Pro Gly Glu Arg Gly Arg Pro Gly Leu Pro Gly Ala Ala Gly Ala Arg 
305                 310                 315                 320 


Gly Asn Asp Gly Ala Arg Gly Ser Asp Gly Gln Pro Gly Pro Pro Gly 
                325                 330                 335     


Pro Pro Gly Xaa Ala Gly Phe Pro Gly Ser Pro Gly Ala Lys Gly Glu 
            340                 345                 350         


Val Gly Pro Ala Gly Ser Pro Gly Ser Asn Gly Ala Pro Gly Gln Arg 
        355                 360                 365             


Gly Glu Pro Gly Pro Gln Gly His Ala Gly Ala Gln Gly Pro Pro Gly 
    370                 375                 380                 


Pro Pro Gly Ile Asn Gly Ser Pro Gly Gly Lys Gly Glu Met Gly Pro 
385                 390                 395                 400 


Ala Gly Ile Pro Gly Ala Pro Gly Leu Met Gly Ala Arg Gly Pro Pro 
                405                 410                 415     


Gly Pro Ala Gly Ala Asn Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly 
            420                 425                 430         


Glu Pro Gly Lys Asn Gly Ala Lys Gly Glu Pro Gly Pro Arg Gly Glu 
        435                 440                 445             


Arg Gly Glu Ala Gly Ile Pro Gly Val Pro Gly Ala Lys Gly Glu Asp 
    450                 455                 460                 


Gly Lys Asp Gly Ser Pro Gly Glu Pro Gly Ala Asn Gly Leu Pro Gly 
465                 470                 475                 480 


Ala Ala Gly Glu Arg Gly Ala Pro Gly Phe Arg Gly Pro Ala Gly Pro 
                485                 490                 495     


Asn Gly Ile Pro Gly Glu Lys Gly Pro Ala Gly Glu Arg Gly Ala Pro 
            500                 505                 510         


Gly Pro Ala Gly Pro Arg Gly Ala Ala Gly Glu Pro Gly Arg Asp Gly 
        515                 520                 525             


Val Pro Gly Gly Pro Gly Met Arg Gly Met Pro Gly Ser Pro Gly Gly 
    530                 535                 540                 


Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser Gln Gly Glu Ser 
545                 550                 555                 560 


Gly Arg Pro Gly Pro Pro Gly Pro Ser Gly Pro Arg Gly Gln Pro Gly 
                565                 570                 575     


Val Met Gly Phe Pro Gly Pro Lys Gly Asn Asp Gly Ala Pro Gly Lys 
            580                 585                 590         


Asn Gly Glu Arg Gly Gly Pro Gly Gly Pro Gly Pro Gln Gly Pro Pro 
        595                 600                 605             


Gly Lys Asn Gly Glu Xaa Gly Pro Gln Gly Pro Pro Gly Pro Xaa Gly 
    610                 615                 620                 


Pro Gly Gly Asp Lys Gly Asp Xaa Gly Pro Pro Gly Pro Gln Gly Leu 
625                 630                 635                 640 


Gln Gly Leu Pro Gly Xaa Gly Gly Pro Pro Gly Glu Asn Gly Lys Pro 
                645                 650                 655     


Gly Glu Pro Gly Pro Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly 
            660                 665                 670         


Gly Lys Gly Asp Ala Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Leu 
        675                 680                 685             


Ala Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly Pro Pro Gly Pro Glu 
    690                 695                 700                 


Gly Gly Lys Gly Ala Ala Gly Pro Pro Gly Pro Pro Gly Ala Ala Gly 
705                 710                 715                 720 


Xaa Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Gly Leu Gly Ser 
                725                 730                 735     


Pro Gly Pro Lys Gly Asp Lys Gly Glu Pro Gly Gly Pro Gly Ala Asp 
            740                 745                 750         


Gly Val Pro Gly Lys Asp Gly Pro Arg Gly Pro Xaa Gly Pro Ile Gly 
        755                 760                 765             


Pro Pro Gly Pro Ala Gly Gln Pro Gly Asp Lys Gly Glu Gly Gly Ala 
    770                 775                 780                 


Pro Gly Leu Pro Gly Ile Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg 
785                 790                 795                 800 


Gly Glu Xaa Gly Pro Pro Gly Pro Ala Gly Phe Pro Gly Ala Pro Gly 
                805                 810                 815     


Gln Asn Gly Glu Pro Gly Gly Lys Gly Glu Arg Gly Ala Pro Gly Glu 
            820                 825                 830         


Lys Gly Glu Gly Gly Pro Pro Gly Val Ala Gly Pro Pro Gly Lys Asp 
        835                 840                 845             


Gly Xaa Ser Gly His Pro Gly Pro Ile Gly Pro Pro Gly Pro Arg Gly 
    850                 855                 860                 


Asn Arg Gly Glu Arg Gly Ser Glu Gly Ser Pro Gly His Pro Gly Gln 
865                 870                 875                 880 


Pro Gly Pro Pro Gly Pro Pro Gly Ala Pro Gly Pro Cys Cys Gly Gly 
                885                 890                 895     


Val Gly Ala Ala Ala Ile Ala Gly Ile Gly Gly Glu Lys Ala Gly Gly 
            900                 905                 910         


Phe Ala Pro Tyr Tyr Gly Asp Glu Pro Met Asp Phe Lys Ile Asn Xaa 
        915                 920                 925             


Asp Glu Ile Met Xaa Ser Leu Lys Ser Val Asn Gly Gln Ile Glu Ser 
    930                 935                 940                 


Leu Ile Ser Pro Asp Gly Ser Arg Lys Asn Pro Ala Arg Asn Cys Arg 
945                 950                 955                 960 


Asp Leu Lys Phe Cys His Pro Glu Leu Lys Ser Gly Glu Tyr Trp Val 
                965                 970                 975     


Asp Pro Asn Gln Gly Cys Lys Leu Asp Ala Ile Lys Val Phe Cys Asn 
            980                 985                 990         


Met Glu Xaa Gly Glu Xaa Cys Ile  Ser Ala Asn Pro Leu  Asn Val Pro 
        995                 1000                 1005             


Arg Lys  His Trp Trp Xaa Asp  Ser Ser Ala Glu Lys  Lys His Val 
    1010                 1015                 1020             


Trp Phe  Gly Glu Ser Met Asp  Gly Gly Phe Gln Phe  Ser Tyr Gly 
    1025                 1030                 1035             


Asn Pro  Glu Leu Pro Glu Asp  Val Leu Asp Val His  Leu Ala Phe 
    1040                 1045                 1050             


Leu Arg  Leu Leu Ser Ser Arg  Ala Ser Gln Asn Ile  Xaa Tyr His 
    1055                 1060                 1065             


Cys Lys  Asn Ser Ile Ala Tyr  Met Asp Gln Ala Ser  Gly Asn Val 
    1070                 1075                 1080             


Lys Lys  Ala Leu Lys Leu Met  Gly Ser Asn Glu Gly  Glu Phe Lys 
    1085                 1090                 1095             


Ala Glu  Gly Asn Ser Lys Phe  Xaa Tyr Xaa Val Leu  Glu Asp Gly 
    1100                 1105                 1110             


Cys Xaa  Lys His Xaa Gly Glu  Trp Ser Lys Xaa Val  Phe Glu Tyr 
    1115                 1120                 1125             


Arg Xaa  Arg Lys Ala Val Arg  Leu Pro Ile Val Asp  Ile Ala Pro 
    1130                 1135                 1140             


Tyr Asp  Ile Gly Gly Pro Asp  Gln Glu Phe Gly Val  Asp Val Gly 
    1145                 1150                 1155             


Pro Val  Cys Phe Leu 
    1160             


<210> 6651
<211> 1466
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1298)..(1298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1317)..(1317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1369)..(1369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1409)..(1409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1411)..(1411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1418)..(1418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1421)..(1421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1427)..(1427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1433)..(1433)
<223> Selenocysteine

<400> 6651
Met Met Ser Phe Val Gln Lys Gly Ser Trp Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


His Pro Xaa Ile Ile Leu Ala Gln Gln Glu Ala Val Glu Gly Gly Cys 
            20                  25                  30          


Ser His Leu Gly Gln Ser Tyr Ala Asp Arg Asp Val Trp Lys Pro Glu 
        35                  40                  45              


Pro Cys Gln Ile Cys Val Cys Asp Ser Gly Ser Val Leu Cys Asp Asp 
    50                  55                  60                  


Ile Ile Cys Asp Asp Gln Glu Leu Asp Cys Pro Asn Pro Glu Ile Pro 
65                  70                  75                  80  


Phe Gly Glu Cys Cys Ala Val Cys Pro Gln Pro Pro Xaa Ala Pro Xaa 
                85                  90                  95      


Arg Pro Pro Asn Gly Gln Gly Pro Gln Gly Pro Lys Gly Asp Pro Gly 
            100                 105                 110         


Pro Pro Gly Ile Pro Gly Arg Asn Gly Asp Pro Gly Ile Pro Gly Gln 
        115                 120                 125             


Pro Gly Ser Pro Gly Ser Pro Gly Pro Pro Gly Ile Cys Glu Ser Cys 
    130                 135                 140                 


Pro Xaa Gly Pro Gln Asn Tyr Ser Pro Gln Tyr Asp Ser Tyr Asp Val 
145                 150                 155                 160 


Lys Ser Gly Val Ala Val Gly Gly Leu Ala Gly Tyr Pro Gly Pro Ala 
                165                 170                 175     


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Xaa Ser Gly His Pro Gly 
            180                 185                 190         


Ser Pro Gly Ser Pro Gly Tyr Gln Gly Pro Pro Gly Glu Pro Gly Gln 
        195                 200                 205             


Ala Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Ala Ile Gly Pro Ser 
    210                 215                 220                 


Gly Pro Ala Gly Lys Asp Gly Glu Ser Gly Arg Pro Gly Arg Pro Gly 
225                 230                 235                 240 


Glu Arg Gly Leu Pro Gly Pro Pro Gly Ile Lys Gly Pro Ala Gly Ile 
                245                 250                 255     


Pro Gly Phe Pro Gly Met Lys Gly His Arg Gly Phe Asp Gly Arg Asn 
            260                 265                 270         


Gly Glu Lys Gly Glu Xaa Gly Ala Pro Gly Leu Lys Gly Glu Asn Gly 
        275                 280                 285             


Leu Pro Gly Glu Asn Gly Ala Pro Gly Pro Met Gly Pro Arg Gly Ala 
    290                 295                 300                 


Pro Gly Glu Arg Gly Arg Pro Gly Leu Pro Gly Ala Ala Gly Ala Arg 
305                 310                 315                 320 


Gly Asn Asp Gly Ala Arg Gly Ser Asp Gly Gln Pro Gly Pro Pro Gly 
                325                 330                 335     


Pro Pro Gly Xaa Ala Gly Phe Pro Gly Ser Pro Gly Ala Lys Gly Glu 
            340                 345                 350         


Val Gly Pro Ala Gly Ser Pro Gly Ser Asn Gly Ala Pro Gly Gln Arg 
        355                 360                 365             


Gly Glu Pro Gly Pro Gln Gly His Ala Gly Ala Gln Gly Pro Pro Gly 
    370                 375                 380                 


Pro Pro Gly Ile Asn Gly Ser Pro Gly Gly Lys Gly Glu Met Gly Pro 
385                 390                 395                 400 


Ala Gly Ile Pro Gly Ala Pro Gly Leu Met Gly Ala Arg Gly Pro Pro 
                405                 410                 415     


Gly Pro Ala Gly Ala Asn Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly 
            420                 425                 430         


Glu Pro Gly Lys Asn Gly Ala Lys Gly Glu Pro Gly Pro Arg Gly Glu 
        435                 440                 445             


Arg Gly Glu Ala Gly Ile Pro Gly Val Pro Gly Ala Lys Gly Glu Asp 
    450                 455                 460                 


Gly Lys Asp Gly Ser Pro Gly Glu Pro Gly Ala Asn Gly Leu Pro Gly 
465                 470                 475                 480 


Ala Ala Gly Glu Arg Gly Ala Pro Gly Phe Arg Gly Pro Ala Gly Pro 
                485                 490                 495     


Asn Gly Ile Pro Gly Glu Lys Gly Pro Ala Gly Glu Arg Gly Ala Pro 
            500                 505                 510         


Gly Pro Ala Gly Pro Arg Gly Ala Ala Gly Glu Pro Gly Arg Asp Gly 
        515                 520                 525             


Val Pro Gly Gly Pro Gly Met Arg Gly Met Pro Gly Ser Pro Gly Gly 
    530                 535                 540                 


Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser Gln Gly Glu Ser 
545                 550                 555                 560 


Gly Arg Pro Gly Pro Pro Gly Pro Ser Gly Pro Arg Gly Gln Pro Gly 
                565                 570                 575     


Val Met Gly Phe Pro Gly Pro Lys Gly Asn Asp Gly Ala Pro Gly Lys 
            580                 585                 590         


Asn Gly Glu Arg Gly Gly Pro Gly Gly Pro Gly Pro Gln Gly Pro Pro 
        595                 600                 605             


Gly Lys Asn Gly Glu Xaa Gly Pro Gln Gly Pro Pro Gly Pro Xaa Gly 
    610                 615                 620                 


Pro Gly Gly Asp Lys Gly Asp Xaa Gly Pro Pro Gly Pro Gln Gly Leu 
625                 630                 635                 640 


Gln Gly Leu Pro Gly Xaa Gly Gly Pro Pro Gly Glu Asn Gly Lys Pro 
                645                 650                 655     


Gly Glu Pro Gly Pro Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly 
            660                 665                 670         


Gly Lys Gly Asp Ala Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Leu 
        675                 680                 685             


Ala Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly Pro Pro Gly Pro Glu 
    690                 695                 700                 


Gly Gly Lys Gly Ala Ala Gly Pro Pro Gly Pro Pro Gly Ala Ala Gly 
705                 710                 715                 720 


Xaa Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Gly Leu Gly Ser 
                725                 730                 735     


Pro Gly Pro Lys Gly Asp Lys Gly Glu Pro Gly Gly Pro Gly Ala Asp 
            740                 745                 750         


Gly Val Pro Gly Lys Asp Gly Pro Arg Gly Pro Xaa Gly Pro Ile Gly 
        755                 760                 765             


Pro Pro Gly Pro Ala Gly Gln Pro Gly Asp Lys Gly Glu Gly Gly Ala 
    770                 775                 780                 


Pro Gly Leu Pro Gly Ile Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg 
785                 790                 795                 800 


Gly Glu Xaa Gly Pro Pro Gly Pro Ala Gly Phe Pro Gly Ala Pro Gly 
                805                 810                 815     


Gln Asn Gly Glu Pro Gly Gly Lys Gly Glu Arg Gly Ala Pro Gly Glu 
            820                 825                 830         


Lys Gly Glu Gly Gly Pro Pro Gly Val Ala Gly Pro Pro Gly Gly Ser 
        835                 840                 845             


Gly Pro Ala Gly Pro Pro Gly Pro Gln Gly Val Lys Gly Glu Arg Gly 
    850                 855                 860                 


Ser Pro Gly Gly Pro Gly Ala Ala Gly Phe Pro Gly Ala Arg Gly Leu 
865                 870                 875                 880 


Pro Gly Pro Pro Gly Ser Asn Gly Asn Pro Gly Pro Pro Gly Pro Ser 
                885                 890                 895     


Gly Ser Pro Gly Lys Asp Gly Pro Pro Gly Pro Ala Gly Asn Xaa Gly 
            900                 905                 910         


Ala Pro Gly Ser Pro Gly Val Ser Gly Pro Lys Gly Asp Ala Gly Gln 
        915                 920                 925             


Pro Gly Glu Lys Gly Ser Pro Gly Ala Gln Gly Pro Pro Gly Ala Pro 
    930                 935                 940                 


Gly Pro Leu Gly Ile Ala Gly Ile Xaa Gly Ala Arg Gly Leu Ala Gly 
945                 950                 955                 960 


Pro Pro Gly Met Pro Gly Pro Arg Gly Ser Pro Gly Pro Gln Gly Val 
                965                 970                 975     


Lys Gly Glu Ser Gly Lys Pro Gly Ala Asn Gly Leu Ser Gly Glu Arg 
            980                 985                 990         


Gly Pro Pro Gly Pro Gln Gly Leu  Pro Gly Leu Ala Gly  Xaa Ala Gly 
        995                 1000                 1005             


Glu Pro  Gly Arg Asp Gly Asn  Pro Gly Ser Asp Gly  Leu Pro Gly 
    1010                 1015                 1020             


Arg Asp  Gly Ser Pro Gly Gly  Lys Gly Asp Arg Gly  Glu Asn Gly 
    1025                 1030                 1035             


Ser Pro  Gly Ala Pro Gly Ala  Pro Gly His Pro Gly  Pro Pro Gly 
    1040                 1045                 1050             


Pro Val  Gly Pro Ala Gly Lys  Ser Gly Asp Arg Gly  Glu Ser Gly 
    1055                 1060                 1065             


Pro Ala  Gly Pro Ala Gly Ala  Pro Gly Pro Ala Gly  Ser Arg Gly 
    1070                 1075                 1080             


Ala Pro  Gly Pro Gln Gly Pro  Arg Gly Asp Lys Gly  Glu Xaa Gly 
    1085                 1090                 1095             


Glu Arg  Gly Ala Ala Gly Ile  Lys Gly His Arg Gly  Phe Pro Gly 
    1100                 1105                 1110             


Asn Pro  Gly Ala Pro Gly Ser  Pro Gly Pro Ala Gly  Gln Gln Gly 
    1115                 1120                 1125             


Ala Ile  Gly Ser Pro Gly Pro  Ala Gly Pro Arg Gly  Pro Val Gly 
    1130                 1135                 1140             


Pro Ser  Gly Pro Pro Gly Lys  Asp Gly Xaa Ser Gly  His Pro Gly 
    1145                 1150                 1155             


Pro Ile  Gly Pro Pro Gly Pro  Arg Gly Asn Arg Gly  Glu Arg Gly 
    1160                 1165                 1170             


Ser Glu  Gly Ser Pro Gly His  Pro Gly Gln Pro Gly  Pro Pro Gly 
    1175                 1180                 1185             


Pro Pro  Gly Ala Pro Gly Pro  Cys Cys Gly Gly Val  Gly Ala Ala 
    1190                 1195                 1200             


Ala Ile  Ala Gly Ile Gly Gly  Glu Lys Ala Gly Gly  Phe Ala Pro 
    1205                 1210                 1215             


Tyr Tyr  Gly Asp Glu Pro Met  Asp Phe Lys Ile Asn  Xaa Asp Glu 
    1220                 1225                 1230             


Ile Met  Xaa Ser Leu Lys Ser  Val Asn Gly Gln Ile  Glu Ser Leu 
    1235                 1240                 1245             


Ile Ser  Pro Asp Gly Ser Arg  Lys Asn Pro Ala Arg  Asn Cys Arg 
    1250                 1255                 1260             


Asp Leu  Lys Phe Cys His Pro  Glu Leu Lys Ser Gly  Glu Tyr Trp 
    1265                 1270                 1275             


Val Asp  Pro Asn Gln Gly Cys  Lys Leu Asp Ala Ile  Lys Val Phe 
    1280                 1285                 1290             


Cys Asn  Met Glu Xaa Gly Glu  Xaa Cys Ile Ser Ala  Asn Pro Leu 
    1295                 1300                 1305             


Asn Val  Pro Arg Lys His Trp  Trp Xaa Asp Ser Ser  Ala Glu Lys 
    1310                 1315                 1320             


Lys His  Val Trp Phe Gly Glu  Ser Met Asp Gly Gly  Phe Gln Phe 
    1325                 1330                 1335             


Ser Tyr  Gly Asn Pro Glu Leu  Pro Glu Asp Val Leu  Asp Val His 
    1340                 1345                 1350             


Leu Ala  Phe Leu Arg Leu Leu  Ser Ser Arg Ala Ser  Gln Asn Ile 
    1355                 1360                 1365             


Xaa Tyr  His Cys Lys Asn Ser  Ile Ala Tyr Met Asp  Gln Ala Ser 
    1370                 1375                 1380             


Gly Asn  Val Lys Lys Ala Leu  Lys Leu Met Gly Ser  Asn Glu Gly 
    1385                 1390                 1395             


Glu Phe  Lys Ala Glu Gly Asn  Ser Lys Phe Xaa Tyr  Xaa Val Leu 
    1400                 1405                 1410             


Glu Asp  Gly Cys Xaa Lys His  Xaa Gly Glu Trp Ser  Lys Xaa Val 
    1415                 1420                 1425             


Phe Glu  Tyr Arg Xaa Arg Lys  Ala Val Arg Leu Pro  Ile Val Asp 
    1430                 1435                 1440             


Ile Ala  Pro Tyr Asp Ile Gly  Gly Pro Asp Gln Glu  Phe Gly Val 
    1445                 1450                 1455             


Asp Val  Gly Pro Val Cys Phe  Leu 
    1460                 1465     


<210> 6652
<211> 90
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<400> 6652
Xaa Arg Gly Ala Pro Gly Glu Arg Gly Arg Pro Gly Leu Pro Gly Ala 
1               5                   10                  15      


Ala Gly Ala Arg Gly Asn Asp Gly Ala Arg Gly Ser Asp Gly Gln Pro 
            20                  25                  30          


Gly Pro Pro Gly Pro Pro Gly Xaa Ala Gly Phe Pro Gly Ser Pro Gly 
        35                  40                  45              


Ala Lys Gly Pro Pro Gly Ile Asn Gly Ser Pro Gly Gly Lys Gly Glu 
    50                  55                  60                  


Met Gly Pro Ala Gly Ile Pro Gly Ala Pro Gly Leu Met Gly Ala Arg 
65                  70                  75                  80  


Gly Pro Pro Gly Pro Ala Gly Ala Asn Gly 
                85                  90  


<210> 6653
<211> 519
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<400> 6653
Met Gly Pro Arg Leu Ser Val Trp Leu Leu Leu Leu Pro Ala Ala Leu 
1               5                   10                  15      


Leu Leu His Glu Glu His Ser Arg Ala Ala Ala Lys Gly Gly Cys Ala 
            20                  25                  30          


Gly Ser Gly Cys Gly Lys Cys Asp Cys His Gly Val Lys Gly Gln Lys 
        35                  40                  45              


Gly Glu Arg Gly Leu Pro Gly Leu Gln Gly Val Ile Gly Phe Pro Gly 
    50                  55                  60                  


Met Gln Gly Pro Glu Gly Pro Gln Gly Pro Pro Gly Gln Lys Gly Asp 
65                  70                  75                  80  


Xaa Gly Glu Pro Gly Leu Pro Gly Xaa Lys Gly Xaa Arg Gly Pro Pro 
                85                  90                  95      


Gly Ala Ser Gly Tyr Pro Gly Asn Pro Gly Leu Pro Gly Ile Pro Gly 
            100                 105                 110         


Gln Asp Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Cys Asn Gly Xaa 
        115                 120                 125             


Lys Gly Glu Arg Gly Pro Leu Gly Pro Pro Gly Leu Pro Gly Phe Ala 
    130                 135                 140                 


Gly Asn Pro Gly Pro Pro Gly Leu Pro Gly Met Lys Gly Asp Pro Gly 
145                 150                 155                 160 


Glu Ile Leu Gly His Val Pro Gly Met Leu Leu Lys Gly Glu Arg Gly 
                165                 170                 175     


Phe Pro Gly Ile Pro Gly Xaa Pro Gly Pro Pro Gly Leu Pro Gly Leu 
            180                 185                 190         


Gln Gly Pro Val Gly Pro Pro Gly Phe Xaa Gly Pro Pro Gly Pro Pro 
        195                 200                 205             


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Gln Met Gly Leu Ser Phe 
    210                 215                 220                 


Gln Gly Pro Lys Gly Asp Lys Gly Asp Gln Gly Val Ser Gly Pro Pro 
225                 230                 235                 240 


Gly Val Pro Gly Gln Ala Gln Val Gln Glu Lys Gly Asp Phe Ala Xaa 
                245                 250                 255     


Lys Gly Glu Lys Gly Gln Lys Gly Glu Pro Gly Phe Gln Gly Met Pro 
            260                 265                 270         


Gly Val Gly Glu Lys Gly Glu Pro Gly Lys Pro Gly Pro Arg Gly Lys 
        275                 280                 285             


Pro Gly Lys Asp Gly Asp Lys Gly Glu Lys Gly Ser Pro Gly Phe Pro 
    290                 295                 300                 


Gly Glu Pro Gly Tyr Pro Gly Leu Ile Gly Arg Gln Gly Pro Gln Gly 
305                 310                 315                 320 


Glu Lys Gly Glu Ala Gly Pro Pro Gly Pro Pro Gly Ile Val Ile Gly 
                325                 330                 335     


Xaa Gly Pro Leu Gly Glu Lys Gly Glu Arg Gly Tyr Pro Gly Xaa Pro 
            340                 345                 350         


Gly Pro Arg Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Leu Pro Gly 
        355                 360                 365             


Gln Pro Gly Pro Pro Gly Leu Pro Val Pro Gly Gln Ala Gly Ala Pro 
    370                 375                 380                 


Gly Phe Pro Gly Glu Arg Gly Glu Lys Gly Asp Arg Gly Phe Pro Gly 
385                 390                 395                 400 


Xaa Ser Leu Pro Gly Pro Ser Gly Arg Asp Gly Leu Pro Gly Pro Pro 
                405                 410                 415     


Gly Ser Pro Gly Pro Pro Gly Gln Pro Gly Tyr Xaa Asn Gly Ile Val 
            420                 425                 430         


Glu Cys Gln Pro Gly Pro Pro Gly Asp Gln Gly Pro Pro Gly Ile Pro 
        435                 440                 445             


Gly Gln Pro Gly Phe Ile Gly Glu Ile Gly Glu Lys Gly Gln Lys Gly 
    450                 455                 460                 


Glu Ser Cys Leu Ile Cys Asp Ile Asp Gly Tyr Arg Gly Pro Pro Gly 
465                 470                 475                 480 


Pro Gln Gly Pro Pro Gly Glu Ile Gly Phe Pro Gly Gln Pro Gly Ala 
                485                 490                 495     


Lys Gly Asp Arg Gly Leu Pro Gly Arg Asp Gly Val Ala Gly Val Pro 
            500                 505                 510         


Leu Leu Phe Gln Ile His Lys 
        515                 


<210> 6654
<211> 1669
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1301)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1386)..(1386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1416)..(1416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1439)..(1439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1449)..(1449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1454)..(1454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1464)..(1464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1489)..(1489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1499)..(1499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1525)..(1525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1537)..(1537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1564)..(1564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1587)..(1587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1635)..(1635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1649)..(1649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1669)..(1669)
<223> Selenocysteine

<400> 6654
Met Gly Pro Arg Leu Ser Val Trp Leu Leu Leu Leu Pro Ala Ala Leu 
1               5                   10                  15      


Leu Leu His Glu Glu His Ser Arg Ala Ala Ala Lys Gly Gly Cys Ala 
            20                  25                  30          


Gly Ser Gly Cys Gly Lys Cys Asp Cys His Gly Val Lys Gly Gln Lys 
        35                  40                  45              


Gly Glu Arg Gly Leu Pro Gly Leu Gln Gly Val Ile Gly Phe Pro Gly 
    50                  55                  60                  


Met Gln Gly Pro Glu Gly Pro Gln Gly Pro Pro Gly Gln Lys Gly Asp 
65                  70                  75                  80  


Xaa Gly Glu Pro Gly Leu Pro Gly Xaa Lys Gly Xaa Arg Gly Pro Pro 
                85                  90                  95      


Gly Ala Ser Gly Tyr Pro Gly Asn Pro Gly Leu Pro Gly Ile Pro Gly 
            100                 105                 110         


Gln Asp Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Cys Asn Gly Xaa 
        115                 120                 125             


Lys Gly Glu Arg Gly Pro Leu Gly Pro Pro Gly Leu Pro Gly Phe Ala 
    130                 135                 140                 


Gly Asn Pro Gly Pro Pro Gly Leu Pro Gly Met Lys Gly Asp Pro Gly 
145                 150                 155                 160 


Glu Ile Leu Gly His Val Pro Gly Met Leu Leu Lys Gly Glu Arg Gly 
                165                 170                 175     


Phe Pro Gly Ile Pro Gly Xaa Pro Gly Pro Pro Gly Leu Pro Gly Leu 
            180                 185                 190         


Gln Gly Pro Val Gly Pro Pro Gly Phe Xaa Gly Pro Pro Gly Pro Pro 
        195                 200                 205             


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Gln Met Gly Leu Ser Phe 
    210                 215                 220                 


Gln Gly Pro Lys Gly Asp Lys Gly Asp Gln Gly Val Ser Gly Pro Pro 
225                 230                 235                 240 


Gly Val Pro Gly Gln Ala Gln Val Gln Glu Lys Gly Asp Phe Ala Xaa 
                245                 250                 255     


Lys Gly Glu Lys Gly Gln Lys Gly Glu Pro Gly Phe Gln Gly Met Pro 
            260                 265                 270         


Gly Val Gly Glu Lys Gly Glu Pro Gly Lys Pro Gly Pro Arg Gly Lys 
        275                 280                 285             


Pro Gly Lys Asp Gly Asp Lys Gly Glu Lys Gly Ser Pro Gly Phe Pro 
    290                 295                 300                 


Gly Glu Pro Gly Tyr Pro Gly Leu Ile Gly Arg Gln Gly Pro Gln Gly 
305                 310                 315                 320 


Glu Lys Gly Glu Ala Gly Pro Pro Gly Pro Pro Gly Ile Val Ile Gly 
                325                 330                 335     


Xaa Gly Pro Leu Gly Glu Lys Gly Glu Arg Gly Tyr Pro Gly Xaa Pro 
            340                 345                 350         


Gly Pro Arg Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Leu Pro Gly 
        355                 360                 365             


Gln Pro Gly Pro Pro Gly Leu Pro Val Pro Gly Gln Ala Gly Ala Pro 
    370                 375                 380                 


Gly Phe Pro Gly Glu Arg Gly Glu Lys Gly Asp Arg Gly Phe Pro Gly 
385                 390                 395                 400 


Xaa Ser Leu Pro Gly Pro Ser Gly Arg Asp Gly Leu Pro Gly Pro Pro 
                405                 410                 415     


Gly Ser Pro Gly Pro Pro Gly Gln Pro Gly Tyr Xaa Asn Gly Ile Val 
            420                 425                 430         


Glu Cys Gln Pro Gly Pro Pro Gly Asp Gln Gly Pro Pro Gly Ile Pro 
        435                 440                 445             


Gly Gln Pro Gly Phe Ile Gly Glu Ile Gly Glu Lys Gly Gln Lys Gly 
    450                 455                 460                 


Glu Ser Cys Leu Ile Cys Asp Ile Asp Gly Tyr Arg Gly Pro Pro Gly 
465                 470                 475                 480 


Pro Gln Gly Pro Pro Gly Glu Ile Gly Phe Pro Gly Gln Pro Gly Ala 
                485                 490                 495     


Lys Gly Asp Arg Gly Leu Pro Gly Arg Asp Gly Val Ala Gly Val Pro 
            500                 505                 510         


Gly Pro Gln Gly Xaa Pro Gly Leu Ile Gly Gln Pro Gly Ala Lys Gly 
        515                 520                 525             


Glu Pro Gly Glu Phe Tyr Phe Asp Leu Arg Leu Lys Gly Asp Lys Gly 
    530                 535                 540                 


Asp Pro Gly Phe Pro Gly Gln Pro Gly Met Pro Gly Arg Ala Gly Ser 
545                 550                 555                 560 


Pro Gly Arg Asp Gly His Pro Gly Leu Pro Gly Pro Lys Gly Ser Pro 
                565                 570                 575     


Gly Ser Val Gly Leu Lys Gly Glu Arg Gly Pro Pro Gly Gly Val Gly 
            580                 585                 590         


Phe Pro Gly Ser Arg Gly Asp Xaa Gly Pro Pro Gly Pro Pro Gly Tyr 
        595                 600                 605             


Gly Pro Ala Gly Pro Ile Gly Asp Lys Gly Gln Ala Gly Phe Pro Gly 
    610                 615                 620                 


Gly Pro Gly Ser Pro Gly Leu Pro Gly Pro Lys Gly Glu Pro Gly Lys 
625                 630                 635                 640 


Ile Val Pro Leu Pro Gly Pro Pro Gly Ala Glu Gly Leu Pro Gly Ser 
                645                 650                 655     


Pro Gly Phe Pro Gly Pro Gln Gly Asp Arg Gly Phe Pro Gly Xaa Pro 
            660                 665                 670         


Gly Arg Pro Gly Leu Pro Gly Glu Lys Gly Ala Val Gly Gln Pro Gly 
        675                 680                 685             


Ile Gly Phe Pro Gly Pro Pro Gly Pro Lys Gly Val Asp Gly Leu Pro 
    690                 695                 700                 


Gly Asp Met Gly Pro Pro Gly Xaa Pro Gly Arg Pro Gly Phe Asn Gly 
705                 710                 715                 720 


Leu Pro Gly Asn Pro Gly Val Gln Gly Gln Lys Gly Glu Pro Gly Val 
                725                 730                 735     


Gly Leu Pro Gly Leu Lys Gly Leu Pro Gly Leu Pro Gly Ile Pro Gly 
            740                 745                 750         


Xaa Pro Gly Glu Lys Gly Ser Ile Gly Val Pro Gly Val Pro Gly Glu 
        755                 760                 765             


His Gly Ala Ile Gly Pro Pro Gly Leu Gln Gly Ile Arg Gly Glu Pro 
    770                 775                 780                 


Gly Pro Pro Gly Leu Pro Gly Ser Val Gly Ser Pro Gly Val Pro Gly 
785                 790                 795                 800 


Ile Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Gly Gln Gly Pro Pro 
                805                 810                 815     


Gly Leu Ser Gly Pro Pro Gly Ile Lys Gly Glu Lys Gly Phe Pro Gly 
            820                 825                 830         


Phe Pro Gly Leu Asp Met Pro Gly Pro Lys Gly Asp Lys Gly Ala Gln 
        835                 840                 845             


Gly Leu Pro Gly Ile Xaa Gly Gln Ser Gly Leu Pro Gly Leu Pro Gly 
    850                 855                 860                 


Gln Gln Gly Ala Pro Gly Ile Pro Gly Phe Pro Gly Ser Lys Gly Glu 
865                 870                 875                 880 


Met Gly Val Met Gly Xaa Pro Gly Gln Pro Gly Ser Pro Gly Pro Val 
                885                 890                 895     


Gly Ala Pro Gly Leu Pro Gly Glu Lys Gly Asp His Gly Phe Pro Gly 
            900                 905                 910         


Ser Ser Gly Pro Arg Gly Asp Pro Gly Leu Lys Gly Asp Lys Gly Asp 
        915                 920                 925             


Val Gly Leu Pro Gly Lys Pro Gly Ser Met Asp Lys Val Asp Met Gly 
    930                 935                 940                 


Ser Met Lys Gly Gln Lys Gly Asp Gln Gly Glu Lys Gly Gln Ile Gly 
945                 950                 955                 960 


Pro Ile Gly Glu Lys Gly Ser Arg Gly Asp Pro Gly Xaa Pro Gly Val 
                965                 970                 975     


Pro Gly Lys Asp Gly Gln Ala Gly Gln Pro Gly Gln Pro Gly Pro Lys 
            980                 985                 990         


Gly Asp Pro Gly Ile Ser Gly Xaa  Pro Gly Ala Pro Gly  Leu Pro Gly 
        995                 1000                 1005             


Pro Lys  Gly Ser Val Gly Gly  Met Gly Leu Pro Gly  Xaa Pro Gly 
    1010                 1015                 1020             


Glu Lys  Gly Val Pro Gly Ile  Pro Gly Pro Gln Gly  Ser Pro Gly 
    1025                 1030                 1035             


Leu Pro  Gly Asp Lys Gly Ala  Lys Gly Glu Lys Gly  Gln Ala Gly 
    1040                 1045                 1050             


Pro Pro  Gly Ile Gly Ile Pro  Gly Leu Arg Gly Glu  Lys Gly Asp 
    1055                 1060                 1065             


Gln Gly  Ile Ala Gly Phe Pro  Gly Ser Pro Gly Glu  Lys Gly Glu 
    1070                 1075                 1080             


Lys Gly  Ser Ile Gly Ile Pro  Gly Met Pro Gly Ser  Pro Gly Leu 
    1085                 1090                 1095             


Lys Gly  Ser Pro Gly Ser Val  Gly Tyr Pro Gly Ser  Pro Gly Leu 
    1100                 1105                 1110             


Pro Gly  Glu Lys Gly Asp Lys  Gly Leu Pro Gly Leu  Asp Gly Ile 
    1115                 1120                 1125             


Pro Gly  Val Lys Gly Glu Ala  Gly Leu Pro Gly Xaa  Pro Gly Pro 
    1130                 1135                 1140             


Xaa Gly  Pro Ala Gly Gln Lys  Gly Glu Pro Gly Ser  Asp Gly Ile 
    1145                 1150                 1155             


Pro Gly  Ser Ala Gly Glu Lys  Gly Glu Pro Gly Leu  Pro Gly Arg 
    1160                 1165                 1170             


Gly Phe  Pro Gly Phe Pro Gly  Ala Lys Gly Asp Lys  Gly Ser Lys 
    1175                 1180                 1185             


Gly Glu  Val Gly Phe Pro Gly  Leu Ala Gly Ser Pro  Gly Ile Pro 
    1190                 1195                 1200             


Gly Ser  Lys Gly Glu Gln Gly  Phe Met Gly Pro Pro  Gly Pro Gln 
    1205                 1210                 1215             


Gly Gln  Pro Gly Leu Pro Gly  Ser Pro Gly His Ala  Xaa Glu Gly 
    1220                 1225                 1230             


Pro Lys  Gly Asp Arg Gly Pro  Gln Gly Gln Pro Gly  Leu Pro Gly 
    1235                 1240                 1245             


Leu Pro  Gly Pro Met Gly Pro  Pro Gly Leu Pro Gly  Ile Asp Gly 
    1250                 1255                 1260             


Val Lys  Gly Asp Lys Gly Asn  Pro Gly Trp Pro Gly  Ala Pro Gly 
    1265                 1270                 1275             


Val Pro  Gly Pro Lys Gly Asp  Pro Gly Phe Gln Gly  Met Pro Gly 
    1280                 1285                 1290             


Ile Gly  Gly Ser Pro Gly Ile  Xaa Gly Ser Lys Gly  Asp Met Gly 
    1295                 1300                 1305             


Pro Pro  Gly Val Pro Gly Phe  Gln Gly Pro Lys Gly  Leu Pro Gly 
    1310                 1315                 1320             


Leu Gln  Gly Ile Lys Gly Asp  Gln Gly Asp Gln Gly  Val Pro Gly 
    1325                 1330                 1335             


Ala Lys  Gly Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Tyr Asp 
    1340                 1345                 1350             


Ile Ile  Lys Gly Glu Pro Gly  Leu Pro Gly Pro Glu  Gly Pro Pro 
    1355                 1360                 1365             


Gly Leu  Lys Gly Leu Gln Gly  Leu Pro Gly Pro Lys  Gly Gln Gln 
    1370                 1375                 1380             


Gly Val  Xaa Gly Leu Val Gly  Ile Pro Gly Pro Pro  Gly Ile Pro 
    1385                 1390                 1395             


Gly Phe  Asp Gly Ala Pro Gly  Gln Lys Gly Glu Met  Gly Pro Ala 
    1400                 1405                 1410             


Gly Pro  Xaa Gly Pro Arg Gly  Phe Pro Gly Pro Pro  Gly Pro Asp 
    1415                 1420                 1425             


Gly Leu  Pro Gly Ser Met Gly  Pro Pro Gly Xaa Pro  Ser Val Asp 
    1430                 1435                 1440             


His Gly  Phe Leu Val Xaa Arg  His Ser Gln Xaa Ile  Asp Asp Pro 
    1445                 1450                 1455             


Gln Cys  Pro Ser Gly Xaa Lys  Ile Leu Tyr His Gly  Tyr Ser Leu 
    1460                 1465                 1470             


Leu Tyr  Val Gln Gly Asn Glu  Arg Ala His Gly Gln  Asp Leu Gly 
    1475                 1480                 1485             


Xaa Ala  Gly Ser Cys Leu Arg  Lys Phe Ser Xaa Met  Pro Phe Leu 
    1490                 1495                 1500             


Phe Cys  Asn Ile Asn Asn Val  Cys Asn Phe Ala Ser  Arg Asn Asp 
    1505                 1510                 1515             


Tyr Ser  Tyr Trp Leu Ser Xaa  Pro Glu Pro Met Pro  Met Ser Met 
    1520                 1525                 1530             


Ala Pro  Ile Xaa Gly Glu Asn  Ile Arg Pro Phe Ile  Ser Arg Cys 
    1535                 1540                 1545             


Ala Val  Cys Glu Ala Pro Ala  Met Val Met Ala Val  His Ser Gln 
    1550                 1555                 1560             


Xaa Ile  Gln Ile Pro Pro Cys  Pro Ser Gly Trp Ser  Ser Leu Trp 
    1565                 1570                 1575             


Ile Gly  Tyr Ser Phe Val Met  His Xaa Ser Ala Gly  Ala Glu Gly 
    1580                 1585                 1590             


Ser Gly  Gln Ala Leu Ala Ser  Pro Gly Ser Cys Leu  Glu Glu Phe 
    1595                 1600                 1605             


Arg Ser  Ala Pro Phe Ile Glu  Cys His Gly Arg Gly  Xaa Cys Asn 
    1610                 1615                 1620             


Tyr Tyr  Ala Asn Ala Tyr Ser  Phe Trp Leu Ala Xaa  Ile Glu Arg 
    1625                 1630                 1635             


Ser Glu  Met Phe Lys Lys Pro  Xaa Pro Ser Xaa Leu  Lys Ala Gly 
    1640                 1645                 1650             


Glu Leu  Arg Xaa His Val Ser  Arg Cys Gln Val Cys  Met Arg Arg 
    1655                 1660                 1665             


Xaa 
    


<210> 6655
<211> 223
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<400> 6655
Met Gln Gly Pro Glu Gly Pro Gln Gly Pro Pro Gly Gln Lys Gly Asp 
1               5                   10                  15      


Xaa Gly Glu Pro Gly Leu Pro Gly Xaa Lys Gly Xaa Arg Gly Pro Pro 
            20                  25                  30          


Gly Ala Ser Gly Tyr Pro Gly Asn Pro Gly Leu Pro Gly Ile Pro Gly 
        35                  40                  45              


Gln Asp Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Cys Asn Gly Xaa 
    50                  55                  60                  


Lys Gly Glu Arg Gly Pro Leu Gly Pro Pro Gly Leu Pro Gly Phe Ala 
65                  70                  75                  80  


Gly Asn Pro Gly Pro Pro Gly Leu Pro Gly Met Lys Gly Asp Pro Gly 
                85                  90                  95      


Glu Ile Leu Gly His Val Pro Gly Met Leu Leu Lys Gly Glu Arg Gly 
            100                 105                 110         


Phe Pro Gly Ile Pro Gly Xaa Pro Gly Pro Pro Gly Leu Pro Gly Leu 
        115                 120                 125             


Gln Gly Pro Val Gly Pro Pro Gly Phe Xaa Gly Pro Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Gln Met Gly Leu Ser Phe 
145                 150                 155                 160 


Gln Gly Pro Lys Gly Asp Lys Gly Asp Gln Gly Val Ser Gly Pro Pro 
                165                 170                 175     


Gly Val Pro Gly Gln Ala Gln Val Gln Glu Lys Gly Asp Phe Ala Xaa 
            180                 185                 190         


Lys Gly Glu Lys Gly Gln Lys Gly Glu Pro Gly Phe Gln Gly Met Pro 
        195                 200                 205             


Gly Val Gly Glu Lys Gly Glu Pro Gly Lys Pro Gly Pro Arg Val 
    210                 215                 220             


<210> 6656
<211> 105
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<400> 6656
Met Gly Arg Asp Gln Arg Ala Val Ala Gly Pro Ala Leu Arg Arg Trp 
1               5                   10                  15      


Leu Leu Leu Gly Xaa Val Xaa Val Gly Phe Leu Ala Gln Ser Val Leu 
            20                  25                  30          


Ala Gly Val Lys Lys Phe Asp Val Pro Cys Gly Gly Arg Asp Cys Ser 
        35                  40                  45              


Gly Gly Cys Gln Cys Tyr Pro Glu Lys Gly Gly Arg Gly Gln Pro Gly 
    50                  55                  60                  


Pro Val Gly Pro Gln Gly Tyr Asn Gly Pro Pro Gly Leu Gln Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Gln Gly Arg Lys Gly Asp Lys Gly Glu Arg Gly Ala Pro 
                85                  90                  95      


Gly Val Xaa Gly Pro Lys Gly Asp Val 
            100                 105 


<210> 6657
<211> 1712
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1313)..(1313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1321)..(1321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1324)..(1324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1361)..(1361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1384)..(1384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1403)..(1403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1498)..(1498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1543)..(1543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1569)..(1570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1629)..(1629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1653)..(1653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1664)..(1664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1677)..(1678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1692)..(1692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1700)..(1700)
<223> Selenocysteine

<400> 6657
Met Gly Arg Asp Gln Arg Ala Val Ala Gly Pro Ala Leu Arg Arg Trp 
1               5                   10                  15      


Leu Leu Leu Gly Xaa Val Xaa Val Gly Phe Leu Ala Gln Ser Val Leu 
            20                  25                  30          


Ala Gly Val Lys Lys Phe Asp Val Pro Cys Gly Gly Arg Asp Cys Ser 
        35                  40                  45              


Gly Gly Cys Gln Cys Tyr Pro Glu Lys Gly Gly Arg Gly Gln Pro Gly 
    50                  55                  60                  


Pro Val Gly Pro Gln Gly Tyr Asn Gly Pro Pro Gly Leu Gln Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Gln Gly Arg Lys Gly Asp Lys Gly Glu Arg Gly Ala Pro 
                85                  90                  95      


Gly Val Xaa Gly Pro Lys Gly Asp Val Gly Ala Arg Gly Val Ser Gly 
            100                 105                 110         


Phe Pro Gly Ala Asp Gly Ile Pro Gly His Pro Gly Gln Gly Gly Pro 
        115                 120                 125             


Arg Gly Arg Pro Gly Tyr Asp Gly Cys Asn Gly Xaa Gln Gly Asp Ser 
    130                 135                 140                 


Gly Pro Gln Gly Pro Pro Gly Ser Glu Gly Phe Xaa Gly Pro Pro Gly 
145                 150                 155                 160 


Pro Gln Gly Pro Lys Gly Gln Lys Gly Glu Pro Tyr Ala Leu Pro Lys 
                165                 170                 175     


Glu Glu Arg Asp Arg Tyr Arg Gly Glu Pro Gly Glu Pro Gly Leu Val 
            180                 185                 190         


Gly Phe Gln Gly Pro Pro Gly Arg Pro Gly His Val Gly Gln Met Gly 
        195                 200                 205             


Pro Val Gly Ala Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro 
    210                 215                 220                 


Lys Gly Gln Gln Gly Asn Arg Gly Leu Gly Phe Tyr Gly Val Lys Gly 
225                 230                 235                 240 


Glu Lys Gly Asp Val Gly Gln Pro Gly Pro Asn Gly Ile Pro Ser Asp 
                245                 250                 255     


Xaa Leu His Pro Ile Ile Ala Pro Xaa Gly Val Xaa Phe His Pro Asp 
            260                 265                 270         


Gln Tyr Lys Gly Glu Lys Gly Ser Glu Gly Glu Pro Gly Ile Arg Gly 
        275                 280                 285             


Ile Ser Leu Lys Gly Glu Glu Gly Ile Met Gly Phe Pro Gly Leu Arg 
    290                 295                 300                 


Gly Tyr Pro Gly Leu Ser Gly Glu Lys Gly Ser Pro Gly Gln Lys Gly 
305                 310                 315                 320 


Ser Arg Gly Leu Asp Gly Tyr Gln Gly Pro Asp Gly Pro Arg Gly Pro 
                325                 330                 335     


Lys Gly Glu Ala Gly Asp Pro Gly Pro Pro Gly Leu Pro Ala Tyr Ser 
            340                 345                 350         


Pro His Pro Ser Leu Ala Lys Gly Ala Arg Gly Asp Pro Gly Phe Pro 
        355                 360                 365             


Gly Ala Gln Gly Glu Pro Gly Ser Gln Gly Glu Pro Gly Asp Pro Gly 
    370                 375                 380                 


Leu Pro Gly Pro Pro Gly Leu Ser Ile Gly Asp Gly Asp Gln Arg Arg 
385                 390                 395                 400 


Gly Leu Pro Gly Glu Met Gly Pro Lys Gly Phe Ile Gly Asp Pro Gly 
                405                 410                 415     


Ile Pro Ala Leu Tyr Gly Gly Pro Pro Gly Pro Asp Gly Lys Arg Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Asp Gly Phe 
        435                 440                 445             


Leu Phe Gly Leu Lys Gly Ala Lys Gly Arg Ala Gly Phe Pro Gly Leu 
    450                 455                 460                 


Pro Gly Ser Pro Gly Ala Arg Gly Pro Lys Gly Trp Lys Gly Asp Ala 
465                 470                 475                 480 


Gly Glu Cys Arg Cys Xaa Glu Gly Asp Glu Ala Ile Lys Gly Leu Pro 
                485                 490                 495     


Gly Leu Pro Gly Pro Lys Gly Phe Ala Gly Ile Asn Gly Glu Pro Gly 
            500                 505                 510         


Arg Lys Gly Asp Arg Gly Asp Pro Gly Gln His Gly Leu Pro Gly Phe 
        515                 520                 525             


Pro Gly Leu Lys Gly Val Pro Gly Asn Ile Gly Ala Pro Gly Pro Lys 
    530                 535                 540                 


Gly Ala Lys Gly Asp Ser Arg Xaa Ile Xaa Xaa Lys Gly Glu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Val Pro Gly Val Pro Gly Met Lys Gly Asp Asp Gly Ser 
                565                 570                 575     


Pro Gly Arg Asp Gly Leu Asp Gly Phe Pro Gly Leu Pro Gly Pro Pro 
            580                 585                 590         


Gly Asp Gly Ile Lys Gly Pro Pro Gly Asp Pro Gly Tyr Pro Gly Ile 
        595                 600                 605             


Pro Gly Xaa Lys Gly Xaa Pro Gly Glu Met Gly Pro Pro Gly Leu Gly 
    610                 615                 620                 


Leu Pro Gly Leu Lys Gly Gln Arg Gly Phe Pro Gly Asp Ala Gly Leu 
625                 630                 635                 640 


Pro Gly Pro Pro Gly Phe Leu Gly Pro Pro Gly Pro Ala Gly Xaa Pro 
                645                 650                 655     


Gly Gln Ile Asp Cys Asp Xaa Asp Val Lys Arg Ala Val Gly Gly Asp 
            660                 665                 670         


Arg Gln Glu Ala Ile Gln Pro Gly Cys Ile Gly Gly Pro Lys Gly Leu 
        675                 680                 685             


Pro Gly Leu Pro Gly Pro Pro Gly Pro Xaa Gly Ala Lys Gly Leu Arg 
    690                 695                 700                 


Gly Ile Pro Gly Phe Ala Gly Ala Asp Gly Gly Pro Gly Pro Arg Gly 
705                 710                 715                 720 


Leu Pro Gly Asp Ala Gly Arg Glu Gly Phe Pro Gly Pro Pro Gly Phe 
                725                 730                 735     


Ile Gly Pro Arg Gly Ser Lys Gly Ala Val Gly Leu Pro Gly Pro Asp 
            740                 745                 750         


Gly Ser Pro Gly Pro Ile Gly Leu Pro Gly Pro Asp Gly Pro Pro Gly 
        755                 760                 765             


Glu Arg Gly Leu Pro Gly Glu Val Leu Gly Ala Gln Pro Gly Pro Arg 
    770                 775                 780                 


Gly Asp Ala Gly Val Pro Gly Gln Pro Gly Leu Lys Gly Leu Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Pro Pro Gly Phe Arg Gly Ser Gln Gly Met Pro Gly Met 
                805                 810                 815     


Pro Gly Leu Lys Gly Gln Pro Gly Leu Pro Gly Pro Ser Gly Gln Pro 
            820                 825                 830         


Gly Leu Tyr Gly Pro Pro Gly Leu His Gly Phe Pro Gly Ala Pro Gly 
        835                 840                 845             


Gln Glu Gly Pro Leu Gly Leu Pro Gly Ile Pro Gly Arg Glu Gly Leu 
    850                 855                 860                 


Pro Gly Asp Arg Gly Asp Pro Gly Asp Xaa Gly Ala Pro Gly Pro Val 
865                 870                 875                 880 


Gly Met Lys Gly Leu Ser Gly Asp Arg Gly Asp Ala Gly Phe Xaa Gly 
                885                 890                 895     


Glu Gln Gly His Pro Gly Ser Pro Gly Phe Lys Gly Ile Asp Gly Met 
            900                 905                 910         


Pro Gly Xaa Pro Gly Leu Lys Gly Asp Arg Gly Ser Pro Gly Met Asp 
        915                 920                 925             


Gly Phe Gln Gly Met Pro Gly Leu Lys Gly Arg Pro Gly Phe Pro Gly 
    930                 935                 940                 


Ser Lys Gly Glu Ala Gly Phe Phe Gly Ile Pro Gly Leu Lys Gly Leu 
945                 950                 955                 960 


Ala Gly Glu Pro Gly Phe Lys Gly Ser Arg Gly Asp Pro Gly Pro Pro 
                965                 970                 975     


Gly Pro Pro Pro Val Ile Leu Pro Gly Met Lys Asp Ile Lys Gly Glu 
            980                 985                 990         


Lys Gly Asp Glu Gly Pro Met Gly  Leu Lys Gly Tyr Leu  Gly Ala Lys 
        995                 1000                 1005             


Gly Ile  Gln Gly Met Pro Gly  Ile Pro Gly Leu Ser  Gly Ile Pro 
    1010                 1015                 1020             


Gly Leu  Pro Gly Arg Pro Gly  His Ile Lys Gly Val  Lys Gly Asp 
    1025                 1030                 1035             


Ile Gly  Val Pro Gly Ile Pro  Gly Leu Pro Gly Phe  Pro Gly Val 
    1040                 1045                 1050             


Ala Gly  Pro Pro Gly Ile Xaa  Gly Phe Pro Gly Phe  Ile Gly Ser 
    1055                 1060                 1065             


Arg Gly  Asp Lys Gly Ala Pro  Gly Arg Ala Gly Leu  Tyr Gly Glu 
    1070                 1075                 1080             


Ile Gly  Ala Xaa Gly Asp Phe  Gly Asp Ile Gly Asp  Xaa Ile Asn 
    1085                 1090                 1095             


Leu Pro  Gly Arg Pro Gly Leu  Lys Gly Glu Arg Gly  Xaa Xaa Gly 
    1100                 1105                 1110             


Ile Pro  Gly Leu Lys Gly Phe  Phe Gly Glu Lys Gly  Xaa Glu Gly 
    1115                 1120                 1125             


Asp Ile  Gly Phe Pro Gly Ile  Xaa Gly Val Xaa Gly  Val Gln Gly 
    1130                 1135                 1140             


Pro Pro  Gly Leu Lys Gly Gln  Xaa Gly Phe Pro Gly  Leu Xaa Gly 
    1145                 1150                 1155             


Pro Pro  Gly Ser Gln Gly Glu  Leu Gly Arg Ile Gly  Leu Pro Gly 
    1160                 1165                 1170             


Gly Lys  Gly Asp Asp Gly Trp  Pro Gly Ala Pro Gly  Leu Pro Gly 
    1175                 1180                 1185             


Phe Pro  Gly Leu Arg Gly Ile  Arg Gly Leu His Gly  Leu Pro Gly 
    1190                 1195                 1200             


Xaa Lys  Gly Phe Pro Gly Ser  Pro Gly Ser Asp Ile  His Gly Asp 
    1205                 1210                 1215             


Pro Gly  Phe Pro Gly Pro Pro  Gly Glu Arg Gly Asp  Pro Gly Glu 
    1220                 1225                 1230             


Ala Asn  Xaa Leu Pro Gly Pro  Val Gly Val Pro Gly  Gln Lys Gly 
    1235                 1240                 1245             


Asp Gln  Gly Ala Pro Gly Glu  Arg Gly Pro Pro Gly  Ser Pro Gly 
    1250                 1255                 1260             


Leu Gln  Gly Phe Pro Gly Ile  Xaa Pro Pro Ser Asn  Ile Ser Gly 
    1265                 1270                 1275             


Ala Pro  Gly Asp Lys Gly Ala  Pro Gly Ile Phe Gly  Leu Lys Gly 
    1280                 1285                 1290             


Tyr Arg  Gly Pro Pro Gly Pro  Pro Gly Ser Ala Ala  Leu Pro Gly 
    1295                 1300                 1305             


Ser Lys  Gly Asp Xaa Gly Asn  Pro Gly Ala Pro Gly  Xaa Pro Gly 
    1310                 1315                 1320             


Xaa Lys  Gly Trp Ala Gly Asp  Ser Gly Pro Gln Gly  Arg Pro Gly 
    1325                 1330                 1335             


Val Phe  Gly Leu Pro Gly Glu  Lys Gly Pro Arg Gly  Glu Gln Gly 
    1340                 1345                 1350             


Phe Met  Gly Asn Xaa Gly Pro  Xaa Gly Ala Val Gly  Asp Arg Gly 
    1355                 1360                 1365             


Pro Lys  Gly Pro Lys Gly Asp  Pro Gly Phe Pro Gly  Ala Pro Gly 
    1370                 1375                 1380             


Xaa Val  Gly Ala Pro Gly Ile  Ala Gly Ile Pro Gln  Lys Ile Ala 
    1385                 1390                 1395             


Val Gln  Pro Gly Xaa Val Gly  Pro Gln Gly Arg Arg  Gly Pro Pro 
    1400                 1405                 1410             


Gly Ala  Pro Gly Glu Met Gly  Pro Gln Gly Pro Pro  Gly Glu Pro 
    1415                 1420                 1425             


Gly Phe  Arg Gly Ala Pro Gly  Lys Ala Gly Pro Gln  Gly Arg Gly 
    1430                 1435                 1440             


Gly Val  Ser Ala Val Pro Gly  Phe Arg Gly Asp Glu  Gly Pro Ile 
    1445                 1450                 1455             


Gly His  Gln Gly Pro Ile Gly  Gln Glu Gly Ala Pro  Gly Arg Pro 
    1460                 1465                 1470             


Gly Ser  Pro Gly Leu Pro Gly  Met Pro Gly Arg Ser  Val Ser Ile 
    1475                 1480                 1485             


Gly Tyr  Leu Leu Val Lys His  Ser Gln Xaa Asp Gln  Glu Pro Met 
    1490                 1495                 1500             


Cys Pro  Val Gly Met Asn Lys  Leu Trp Ser Gly Tyr  Ser Leu Leu 
    1505                 1510                 1515             


Tyr Phe  Glu Gly Gln Glu Lys  Ala His Asn Gln Asp  Leu Gly Leu 
    1520                 1525                 1530             


Ala Gly  Ser Cys Leu Ala Arg  Phe Ser Xaa Met Pro  Phe Leu Tyr 
    1535                 1540                 1545             


Cys Asn  Pro Gly Asp Val Cys  Tyr Tyr Ala Ser Arg  Asn Asp Lys 
    1550                 1555                 1560             


Ser Tyr  Trp Leu Ser Xaa Xaa  Ala Pro Leu Pro Met  Met Pro Val 
    1565                 1570                 1575             


Ala Glu  Asp Glu Ile Lys Pro  Tyr Ile Ser Arg Cys  Ser Val Cys 
    1580                 1585                 1590             


Glu Ala  Pro Ala Ile Ala Ile  Ala Val His Ser Gln  Asp Val Ser 
    1595                 1600                 1605             


Ile Pro  His Cys Pro Ala Gly  Trp Arg Ser Leu Trp  Ile Gly Tyr 
    1610                 1615                 1620             


Ser Phe  Leu Met His Xaa Ala  Ala Gly Asp Glu Gly  Gly Gly Gln 
    1625                 1630                 1635             


Ser Leu  Val Ser Pro Gly Ser  Cys Leu Glu Asp Phe  Arg Ala Xaa 
    1640                 1645                 1650             


Pro Phe  Ile Glu Cys Asn Gly  Gly Arg Gly Xaa Cys  His Tyr Tyr 
    1655                 1660                 1665             


Ala Asn  Lys Tyr Ser Phe Trp  Leu Xaa Xaa Ile Pro  Glu Gln Ser 
    1670                 1675                 1680             


Phe Gln  Gly Ser Pro Ser Ala  Asp Xaa Leu Lys Ala  Gly Leu Ile 
    1685                 1690                 1695             


Arg Xaa  His Ile Ser Arg Cys  Gln Val Cys Met Lys  Asn Leu 
    1700                 1705                 1710         


<210> 6658
<211> 42
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 6658
Xaa Gly Asp Pro Gly Gln His Gly Leu Pro Gly Phe Pro Gly Leu Lys 
1               5                   10                  15      


Val Arg Ser Asn Phe Ile Met Lys Leu Ala Arg His Ser Glu Ala Ser 
            20                  25                  30          


Pro Gly Val Pro Phe Leu Pro Phe Ile Ser 
        35                  40          


<210> 6659
<211> 156
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<400> 6659
Gly Asn Pro Gly Glu Lys Gly Asn Arg Gly Val Pro Gly Met Pro Gly 
1               5                   10                  15      


Leu Lys Gly Leu Lys Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Pro 
            20                  25                  30          


Arg Gly Asp Leu Gly Ser Xaa Gly Asn Pro Gly Glu Pro Gly Leu Arg 
        35                  40                  45              


Gly Ile Pro Gly Ser Met Gly Asn Met Gly Met Pro Gly Ser Lys Gly 
    50                  55                  60                  


Lys Arg Gly Xaa Leu Gly Phe Pro Gly Arg Ala Gly Arg Pro Gly Leu 
65                  70                  75                  80  


Pro Gly Ile His Gly Leu Gln Gly Asp Lys Gly Glu Pro Gly Tyr Ser 
                85                  90                  95      


Glu Gly Xaa Arg Pro Gly Pro Pro Gly Pro Xaa Gly Asp Pro Gly Leu 
            100                 105                 110         


Pro Gly Asp Met Gly Lys Lys Gly Glu Met Gly Gln Pro Gly Pro Pro 
        115                 120                 125             


Gly His Leu Gly Pro Ala Gly Pro Glu Gly Ala Pro Gly Ser Pro Gly 
    130                 135                 140                 


Ser Pro Gly Leu Pro Val Pro Ala Ala Pro Ser Leu 
145                 150                 155     


<210> 6660
<211> 1670
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1218)..(1218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1238)..(1238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1299)..(1299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1350)..(1350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1365)..(1365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1401)..(1401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1440)..(1440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1442)..(1443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1449)..(1449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1454)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1464)..(1464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1489)..(1489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1498)..(1499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1525)..(1525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1537)..(1537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1549)..(1549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1564)..(1565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1587)..(1587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1649)..(1649)
<223> Selenocysteine

<400> 6660
Met Ser Ala Arg Xaa Ala Pro Arg Pro Gln Val Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Leu Val Leu Leu Ala Ala Ala Pro Ala Ala Ser Lys Gly Cys Val 
            20                  25                  30          


Cys Lys Asp Lys Gly Gln Cys Phe Cys Asp Gly Ala Lys Gly Glu Lys 
        35                  40                  45              


Gly Glu Lys Gly Phe Pro Gly Pro Pro Gly Ser Pro Gly Gln Lys Gly 
    50                  55                  60                  


Phe Xaa Gly Pro Glu Gly Leu Pro Gly Pro Gln Gly Pro Lys Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Pro Gly Leu Xaa Gly Ser Lys Gly Val Arg Gly Ile Ser 
                85                  90                  95      


Gly Leu Pro Gly Phe Ser Gly Ser Pro Gly Leu Pro Gly Xaa Pro Gly 
            100                 105                 110         


Asn Xaa Gly Pro Tyr Gly Leu Val Gly Val Pro Gly Cys Ser Gly Ser 
        115                 120                 125             


Lys Gly Glu Gln Gly Phe Pro Gly Leu Pro Gly Xaa Leu Gly Tyr Pro 
    130                 135                 140                 


Gly Ile Pro Gly Ala Ala Gly Leu Lys Gly Gln Lys Gly Ala Pro Ala 
145                 150                 155                 160 


Lys Glu Glu Asp Ile Glu Leu Asp Ala Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Ala Pro Gly Pro Gln Gly Leu Pro Gly Pro Pro Gly Phe Pro Gly 
            180                 185                 190         


Pro Val Gly Pro Pro Gly Pro Pro Gly Phe Phe Gly Phe Pro Gly Ala 
        195                 200                 205             


Met Gly Pro Arg Gly Pro Lys Gly His Met Gly Glu Arg Val Ile Gly 
    210                 215                 220                 


His Lys Gly Glu Arg Gly Val Lys Gly Leu Xaa Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Xaa Val Ile Val Xaa Leu Xaa Gly Pro Asp Asn Arg Xaa Asp 
                245                 250                 255     


Leu Lys Gly Glu Lys Gly Asp Lys Gly Ala Met Gly Glu Pro Gly Pro 
            260                 265                 270         


Pro Gly Pro Ser Gly Leu Pro Gly Glu Ser Tyr Gly Ser Glu Lys Gly 
        275                 280                 285             


Ala Pro Gly Asp Pro Gly Leu Gln Gly Lys Pro Gly Lys Asp Gly Val 
    290                 295                 300                 


Pro Gly Phe Pro Gly Ser Glu Gly Val Lys Gly Asn Arg Gly Phe Pro 
305                 310                 315                 320 


Gly Leu Met Gly Glu Asp Gly Ile Lys Gly Gln Lys Gly Asp Ile Gly 
                325                 330                 335     


Pro Pro Gly Phe Arg Gly Pro Xaa Glu Tyr Tyr Asp Xaa Tyr Gln Glu 
            340                 345                 350         


Lys Gly Asp Glu Gly Xaa Pro Gly Pro Pro Gly Pro Arg Gly Ala Arg 
        355                 360                 365             


Gly Pro Gln Gly Pro Ser Gly Pro Pro Gly Val Pro Gly Ser Pro Gly 
    370                 375                 380                 


Ser Ser Arg Pro Gly Leu Arg Gly Ala Pro Gly Trp Pro Gly Leu Lys 
385                 390                 395                 400 


Gly Ser Lys Gly Glu Arg Gly Arg Pro Gly Lys Asp Ala Met Gly Xaa 
                405                 410                 415     


Pro Gly Ser Pro Gly Cys Ala Gly Ser Pro Gly Leu Pro Gly Ser Pro 
            420                 425                 430         


Gly Pro Pro Gly Pro Pro Gly Asp Ile Val Phe Arg Lys Gly Pro Pro 
        435                 440                 445             


Gly Asp His Gly Leu Pro Gly Tyr Leu Gly Ser Pro Gly Ile Pro Gly 
    450                 455                 460                 


Val Asp Gly Pro Lys Gly Glu Pro Gly Leu Leu Cys Xaa Gln Cys Pro 
465                 470                 475                 480 


Tyr Ile Pro Gly Pro Pro Gly Leu Pro Gly Leu Pro Gly Leu His Gly 
                485                 490                 495     


Val Lys Gly Ile Pro Gly Arg Gln Gly Ala Ala Gly Leu Lys Gly Ser 
            500                 505                 510         


Pro Gly Ser Pro Gly Asn Xaa Gly Leu Pro Gly Phe Pro Gly Phe Pro 
        515                 520                 525             


Gly Ala Gln Gly Asp Pro Gly Leu Lys Gly Glu Lys Gly Glu Xaa Leu 
    530                 535                 540                 


Gln Pro Glu Gly Gln Val Gly Val Pro Gly Asp Pro Gly Leu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Arg Lys Gly Leu Asp Gly Ile Pro Gly Xaa Pro Gly Val 
                565                 570                 575     


Lys Gly Leu Pro Gly Pro Lys Gly Glu Leu Ala Leu Ser Gly Glu Lys 
            580                 585                 590         


Gly Asp Gln Gly Pro Pro Gly Asp Pro Gly Ser Pro Gly Ser Pro Gly 
        595                 600                 605             


Pro Ala Gly Pro Ala Gly Pro Pro Gly Tyr Gly Pro Gln Gly Glu Pro 
    610                 615                 620                 


Gly Leu Gln Gly Xaa Gln Gly Val Pro Gly Ala Pro Gly Pro Pro Gly 
625                 630                 635                 640 


Glu Ala Gly Pro Arg Gly Glu Leu Ser Val Ser Xaa Pro Val Pro Gly 
                645                 650                 655     


Pro Pro Gly Pro Pro Gly Pro Pro Gly His Pro Gly Pro Gln Gly Pro 
            660                 665                 670         


Pro Gly Ile Pro Gly Ser Leu Gly Lys Cys Gly Asp Pro Gly Leu Pro 
        675                 680                 685             


Gly Pro Asp Gly Glu Pro Gly Ile Pro Gly Ile Gly Phe Pro Gly Pro 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asp Gln Gly Phe Pro Gly Xaa Lys Gly Ser Leu 
705                 710                 715                 720 


Gly Cys Pro Gly Lys Met Gly Glu Pro Gly Leu Pro Gly Lys Pro Gly 
                725                 730                 735     


Leu Pro Gly Ala Lys Gly Glu Pro Ala Val Ala Met Pro Gly Gly Pro 
            740                 745                 750         


Gly Xaa Pro Gly Phe Pro Gly Glu Arg Gly Asn Ser Gly Glu His Gly 
        755                 760                 765             


Glu Ile Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Xaa Pro Gly Asn 
    770                 775                 780                 


Glu Gly Leu Asp Gly Pro Arg Gly Asp Pro Gly Gln Pro Gly Pro Pro 
785                 790                 795                 800 


Gly Glu Gln Gly Pro Pro Gly Arg Cys Ile Glu Gly Pro Arg Gly Ala 
                805                 810                 815     


Gln Gly Leu Pro Gly Leu Asn Gly Leu Lys Gly Gln Gln Gly Arg Arg 
            820                 825                 830         


Gly Lys Xaa Gly Pro Lys Gly Asp Pro Gly Ile Pro Gly Leu Asp Arg 
        835                 840                 845             


Ser Gly Phe Pro Gly Glu Xaa Gly Ser Pro Gly Ile Pro Gly His Gln 
    850                 855                 860                 


Gly Glu Met Gly Pro Leu Gly Gln Arg Gly Tyr Pro Gly Asn Pro Gly 
865                 870                 875                 880 


Ile Leu Gly Pro Pro Gly Glu Asp Gly Val Ile Gly Met Met Gly Phe 
                885                 890                 895     


Pro Gly Ala Ile Gly Pro Pro Gly Pro Pro Gly Asn Pro Gly Xaa Pro 
            900                 905                 910         


Gly Gln Arg Gly Ser Pro Gly Ile Pro Gly Val Lys Gly Gln Arg Gly 
        915                 920                 925             


Xaa Pro Gly Ala Lys Gly Glu Gln Gly Asp Lys Gly Asn Pro Gly Pro 
    930                 935                 940                 


Ser Glu Ile Ser His Val Ile Gly Asp Lys Gly Glu Pro Gly Leu Lys 
945                 950                 955                 960 


Gly Phe Ala Gly Asn Pro Gly Glu Lys Gly Asn Arg Gly Val Pro Gly 
                965                 970                 975     


Met Pro Gly Leu Lys Gly Leu Lys Gly Leu Pro Gly Pro Ala Gly Pro 
            980                 985                 990         


Pro Gly Pro Arg Gly Asp Leu Gly  Ser Xaa Gly Asn Pro  Gly Glu Pro 
        995                 1000                 1005             


Gly Leu  Arg Gly Ile Pro Gly  Ser Met Gly Asn Met  Gly Met Pro 
    1010                 1015                 1020             


Gly Ser  Lys Gly Lys Arg Gly  Xaa Leu Gly Phe Pro  Gly Arg Ala 
    1025                 1030                 1035             


Gly Arg  Pro Gly Leu Pro Gly  Ile His Gly Leu Gln  Gly Asp Lys 
    1040                 1045                 1050             


Gly Glu  Pro Gly Tyr Ser Glu  Gly Xaa Arg Pro Gly  Pro Pro Gly 
    1055                 1060                 1065             


Pro Xaa  Gly Asp Pro Gly Leu  Pro Gly Asp Met Gly  Lys Lys Gly 
    1070                 1075                 1080             


Glu Met  Gly Gln Pro Gly Pro  Pro Gly His Leu Gly  Pro Ala Gly 
    1085                 1090                 1095             


Pro Glu  Gly Ala Pro Gly Ser  Pro Gly Ser Pro Gly  Leu Pro Gly 
    1100                 1105                 1110             


Lys Pro  Gly Pro His Gly Asp  Leu Gly Phe Lys Gly  Ile Lys Gly 
    1115                 1120                 1125             


Leu Leu  Gly Pro Pro Gly Ile  Arg Gly Pro Pro Gly  Leu Pro Gly 
    1130                 1135                 1140             


Phe Pro  Gly Ser Pro Gly Pro  Met Gly Ile Arg Gly  Asp Gln Gly 
    1145                 1150                 1155             


Arg Asp  Gly Ile Pro Gly Pro  Ala Gly Glu Lys Gly  Glu Xaa Gly 
    1160                 1165                 1170             


Leu Leu  Arg Ala Pro Pro Gly  Pro Arg Gly Asn Pro  Gly Ala Gln 
    1175                 1180                 1185             


Gly Ala  Lys Gly Asp Arg Gly  Ala Pro Gly Phe Pro  Gly Leu Pro 
    1190                 1195                 1200             


Gly Arg  Lys Gly Ala Met Gly  Asp Ala Gly Pro Arg  Gly Pro Xaa 
    1205                 1210                 1215             


Gly Ile  Glu Gly Phe Pro Gly  Pro Pro Gly Leu Pro  Gly Ala Ile 
    1220                 1225                 1230             


Ile Pro  Gly Gln Xaa Gly Asn  Arg Gly Pro Pro Gly  Ser Arg Gly 
    1235                 1240                 1245             


Ser Pro  Gly Ala Pro Gly Pro  Pro Gly Pro Pro Gly  Ser His Val 
    1250                 1255                 1260             


Ile Gly  Ile Lys Gly Asp Lys  Gly Ser Met Gly His  Pro Gly Pro 
    1265                 1270                 1275             


Lys Gly  Pro Pro Gly Xaa Ala  Gly Asp Met Gly Pro  Pro Gly Arg 
    1280                 1285                 1290             


Leu Gly  Ala Pro Gly Xaa Pro  Gly Leu Pro Gly Pro  Arg Gly Asp 
    1295                 1300                 1305             


Pro Gly  Phe Gln Gly Phe Pro  Gly Val Lys Gly Glu  Lys Gly Asn 
    1310                 1315                 1320             


Pro Gly  Phe Leu Gly Ser Ile  Gly Pro Pro Gly Pro  Ile Gly Pro 
    1325                 1330                 1335             


Lys Gly  Pro Pro Gly Val Arg  Gly Asp Pro Gly Xaa  Leu Lys Ile 
    1340                 1345                 1350             


Ile Ser  Leu Pro Gly Ser Pro  Gly Pro Pro Gly Xaa  Pro Gly Glu 
    1355                 1360                 1365             


Pro Gly  Met Gln Gly Glu Pro  Gly Pro Pro Gly Pro  Pro Gly Asn 
    1370                 1375                 1380             


Leu Gly  Pro Cys Gly Pro Arg  Gly Lys Pro Gly Lys  Asp Gly Lys 
    1385                 1390                 1395             


Pro Gly  Xaa Pro Gly Pro Ala  Gly Glu Lys Gly Asn  Lys Gly Ser 
    1400                 1405                 1410             


Lys Gly  Glu Pro Gly Pro Ala  Gly Ser Asp Gly Leu  Pro Gly Leu 
    1415                 1420                 1425             


Lys Gly  Lys Arg Gly Asp Ser  Gly Ser Pro Ala Xaa  Trp Xaa Xaa 
    1430                 1435                 1440             


Arg Gly  Phe Val Phe Xaa Arg  His Ser Gln Xaa Xaa  Ala Ile Pro 
    1445                 1450                 1455             


Ser Cys  Pro Glu Gly Xaa Val  Pro Leu Tyr Ser Gly  Phe Ser Phe 
    1460                 1465                 1470             


Leu Phe  Val Gln Gly Asn Gln  Arg Ala His Gly Gln  Asp Leu Gly 
    1475                 1480                 1485             


Xaa Leu  Gly Ser Cys Leu Gln  Arg Phe Xaa Xaa Met  Pro Phe Leu 
    1490                 1495                 1500             


Phe Cys  Asn Val Asn Asp Val  Cys Asn Phe Ala Ser  Arg Asn Asp 
    1505                 1510                 1515             


Tyr Ser  Tyr Trp Leu Ser Xaa  Pro Ala Leu Met Pro  Met Asn Met 
    1520                 1525                 1530             


Ala Pro  Ile Xaa Gly Arg Ala  Leu Glu Pro Tyr Ile  Ser Arg Cys 
    1535                 1540                 1545             


Xaa Val  Cys Glu Gly Pro Ala  Ile Ala Ile Ala Val  His Ser Gln 
    1550                 1555                 1560             


Xaa Xaa  Asp Ile Pro Pro Cys  Pro His Gly Trp Ile  Ser Leu Trp 
    1565                 1570                 1575             


Lys Gly  Phe Ser Phe Ile Met  Phe Xaa Ser Ala Gly  Ser Glu Gly 
    1580                 1585                 1590             


Xaa Gly  Gln Ala Leu Ala Ser  Pro Gly Ser Cys Leu  Glu Glu Phe 
    1595                 1600                 1605             


Arg Ala  Ser Pro Phe Leu Glu  Cys His Gly Arg Gly  Xaa Cys Asn 
    1610                 1615                 1620             


Tyr Tyr  Ser Asn Ser Tyr Ser  Phe Trp Leu Ala Ser  Leu Asn Pro 
    1625                 1630                 1635             


Glu Arg  Met Phe Arg Lys Pro  Ile Pro Ser Xaa Val  Lys Ala Gly 
    1640                 1645                 1650             


Glu Leu  Glu Lys Ile Ile Ser  Arg Cys Gln Val Cys  Met Lys Lys 
    1655                 1660                 1665             


Arg His  
    1670 


<210> 6661
<211> 752
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<400> 6661
Met Gln His Ser Cys Ile Pro Xaa Pro Pro Ser Pro Phe Ser Ala Pro 
1               5                   10                  15      


Pro Ala Phe Leu Pro Val Val Xaa Arg Glu Ser Arg Arg Gly Leu Ser 
            20                  25                  30          


Ser Gly Gly Ser Ala Gly Arg Asn Ala Gly Val Xaa Ala Xaa Ala Ala 
        35                  40                  45              


Ala Ala Asp Gly Trp Lys Gly Arg Leu Pro Ser Pro Leu Val Leu Leu 
    50                  55                  60                  


Pro Arg Ser Ala Arg Cys Gln Ala Arg Arg Arg Arg Gly Gly Arg Xaa 
65                  70                  75                  80  


Ser Ser Leu Leu Leu Leu Pro Pro Xaa Pro Glu Arg Ala Leu Phe Ala 
                85                  90                  95      


Ser Pro Ser Pro Asp Pro Ser Pro Arg Gly Leu Gly Ala Ser Ser Gly 
            100                 105                 110         


Ala Ala Glu Gly Ala Gly Ala Gly Leu Leu Leu Gly Cys Arg Ala Ser 
        115                 120                 125             


Met Ser Asp Asn Gln Ser Trp Asn Ser Ser Gly Ser Glu Glu Asp Pro 
    130                 135                 140                 


Glu Xaa Glu Ser Gly Pro Pro Val Glu Arg Cys Gly Val Leu Ser Lys 
145                 150                 155                 160 


Trp Xaa Asn Tyr Ile His Gly Trp Gln Asp Arg Trp Val Val Leu Lys 
                165                 170                 175     


Asn Asn Ala Leu Ser Tyr Tyr Lys Ser Glu Asp Glu Xaa Glu Tyr Gly 
            180                 185                 190         


Cys Arg Gly Ser Ile Cys Leu Ser Lys Ala Val Ile Xaa Pro His Asp 
        195                 200                 205             


Phe Asp Glu Cys Arg Phe Asp Ile Ser Val Asn Asp Ser Val Trp Tyr 
    210                 215                 220                 


Leu Arg Ala Gln Asp Pro Asp His Arg Gln Gln Trp Ile Asp Ala Ile 
225                 230                 235                 240 


Glu Gln His Lys Xaa Glu Ser Gly Tyr Gly Ser Glu Ser Ser Leu Arg 
                245                 250                 255     


Arg His Gly Ser Met Val Ser Leu Val Ser Gly Ala Ser Gly Tyr Ser 
            260                 265                 270         


Ala Xaa Ser Xaa Ser Ser Phe Lys Lys Gly His Ser Leu Arg Glu Lys 
        275                 280                 285             


Leu Ala Glu Met Glu Xaa Phe Arg Asp Ile Leu Cys Arg Gln Val Asp 
    290                 295                 300                 


Xaa Leu Gln Lys Tyr Phe Asp Ala Cys Ala Asp Ala Val Ser Lys Asp 
305                 310                 315                 320 


Glu Leu Gln Arg Asp Lys Val Val Glu Asp Asp Glu Asp Asp Phe Pro 
                325                 330                 335     


Xaa Xaa Arg Ser Asp Gly Asp Phe Leu His Ser Xaa Asn Gly Asn Lys 
            340                 345                 350         


Glu Lys Leu Phe Pro His Val Xaa Pro Lys Gly Ile Asn Gly Ile Asp 
        355                 360                 365             


Phe Lys Gly Glu Ala Ile Xaa Phe Lys Ala Xaa Xaa Ala Gly Ile Leu 
    370                 375                 380                 


Ala Xaa Leu Ser His Cys Ile Glu Leu Met Val Lys Arg Glu Asp Ser 
385                 390                 395                 400 


Trp Gln Lys Arg Leu Asp Lys Glu Xaa Glu Lys Lys Arg Arg Xaa Glu 
                405                 410                 415     


Glu Ala Tyr Lys Asn Ala Met Xaa Glu Leu Lys Lys Lys Ser His Phe 
            420                 425                 430         


Gly Gly Pro Asp Tyr Glu Glu Gly Pro Asn Ser Leu Ile Asn Glu Glu 
        435                 440                 445             


Glu Phe Phe Asp Ala Val Glu Ala Ala Leu Asp Arg Gln Asp Lys Ile 
    450                 455                 460                 


Glu Glu Gln Ser Gln Ser Glu Lys Val Arg Leu His Trp Pro Xaa Ser 
465                 470                 475                 480 


Leu Pro Ser Gly Asp Ala Phe Ser Ser Val Gly Xaa His Arg Phe Val 
                485                 490                 495     


Gln Lys Pro Tyr Ser Arg Ser Ser Ser Met Ser Ser Ile Asp Leu Val 
            500                 505                 510         


Ser Ala Ser Asp Asp Val His Arg Phe Ser Ser Gln Val Glu Glu Met 
        515                 520                 525             


Val Gln Asn His Met Xaa Tyr Ser Leu Gln Asp Val Gly Gly Asp Ala 
    530                 535                 540                 


Asn Trp Gln Leu Val Val Glu Glu Gly Glu Met Lys Val Tyr Arg Arg 
545                 550                 555                 560 


Glu Val Glu Glu Asn Gly Ile Val Leu Asp Pro Leu Lys Ala Xaa His 
                565                 570                 575     


Ala Val Lys Gly Val Xaa Gly His Glu Val Cys Asn Tyr Phe Trp Asn 
            580                 585                 590         


Val Asp Val Arg Asn Asp Trp Glu Xaa Xaa Ile Glu Asn Phe His Val 
        595                 600                 605             


Val Glu Xaa Leu Ala Asp Asn Ala Ile Ile Ile Tyr Gln Xaa His Lys 
    610                 615                 620                 


Arg Val Trp Pro Ala Ser Gln Arg Asp Val Leu Tyr Leu Ser Val Ile 
625                 630                 635                 640 


Arg Lys Ile Pro Ala Leu Xaa Glu Asn Asp Pro Glu Xaa Trp Ile Val 
                645                 650                 655     


Cys Asn Phe Ser Val Asp His Asp Ser Ala Pro Leu Asn Asn Arg Cys 
            660                 665                 670         


Val Arg Ala Lys Ile Asn Val Ala Met Ile Cys Gln Xaa Leu Val Ser 
        675                 680                 685             


Pro Pro Glu Gly Asn Gln Glu Ile Ser Arg Asp Asn Ile Leu Cys Lys 
    690                 695                 700                 


Ile Xaa Tyr Val Ala Asn Val Asn Pro Gly Gly Trp Ala Pro Ala Ser 
705                 710                 715                 720 


Val Leu Arg Ala Val Ala Lys Arg Glu Tyr Pro Lys Phe Leu Lys Arg 
                725                 730                 735     


Phe Xaa Ser Tyr Val Gln Glu Lys Xaa Ala Gly Lys Pro Ile Leu Phe 
            740                 745                 750         


<210> 6662
<211> 598
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<400> 6662
Met Ser Asp Asn Gln Ser Trp Asn Ser Ser Gly Ser Glu Glu Asp Pro 
1               5                   10                  15      


Glu Xaa Glu Ser Gly Pro Pro Val Glu Arg Cys Gly Val Leu Ser Lys 
            20                  25                  30          


Trp Xaa Asn Tyr Ile His Gly Trp Gln Asp Arg Trp Val Val Leu Lys 
        35                  40                  45              


Asn Asn Ala Leu Ser Tyr Tyr Lys Ser Glu Asp Glu Xaa Glu Tyr Gly 
    50                  55                  60                  


Cys Arg Gly Ser Ile Cys Leu Ser Lys Ala Val Ile Xaa Pro His Asp 
65                  70                  75                  80  


Phe Asp Glu Cys Arg Phe Asp Ile Ser Val Asn Asp Ser Val Trp Tyr 
                85                  90                  95      


Leu Arg Ala Gln Asp Pro Asp His Arg Gln Gln Trp Ile Asp Ala Ile 
            100                 105                 110         


Glu Gln His Lys Xaa Glu Ser Gly Tyr Gly Ser Glu Ser Ser Leu Arg 
        115                 120                 125             


Arg His Gly Ser Met Val Ser Leu Val Ser Gly Ala Ser Gly Tyr Ser 
    130                 135                 140                 


Ala Xaa Ser Xaa Ser Ser Phe Lys Lys Gly His Ser Leu Arg Glu Lys 
145                 150                 155                 160 


Leu Ala Glu Met Glu Xaa Phe Arg Asp Ile Leu Cys Arg Gln Val Asp 
                165                 170                 175     


Xaa Leu Gln Lys Tyr Phe Asp Ala Cys Ala Asp Ala Val Ser Lys Asp 
            180                 185                 190         


Glu Leu Gln Arg Asp Lys Val Val Glu Asp Asp Glu Asp Asp Phe Pro 
        195                 200                 205             


Xaa Xaa Arg Ser Asp Gly Asp Phe Leu His Ser Xaa Asn Gly Asn Lys 
    210                 215                 220                 


Glu Lys Leu Phe Pro His Val Xaa Pro Lys Gly Ile Asn Gly Ile Asp 
225                 230                 235                 240 


Phe Lys Gly Glu Ala Ile Xaa Phe Lys Ala Xaa Xaa Ala Gly Ile Leu 
                245                 250                 255     


Ala Xaa Leu Ser His Cys Ile Glu Leu Met Val Lys Arg Glu Asp Ser 
            260                 265                 270         


Trp Gln Lys Arg Leu Asp Lys Glu Xaa Glu Lys Lys Arg Arg Xaa Glu 
        275                 280                 285             


Glu Ala Tyr Lys Asn Ala Met Xaa Glu Leu Lys Lys Lys Ser His Phe 
    290                 295                 300                 


Gly Gly Pro Asp Tyr Glu Glu Gly Pro Asn Ser Leu Ile Asn Glu Glu 
305                 310                 315                 320 


Glu Phe Phe Asp Ala Val Glu Ala Ala Leu Asp Arg Gln Asp Lys Ile 
                325                 330                 335     


Glu Glu Gln Ser Gln Ser Glu Lys Val Arg Leu His Trp Pro Xaa Ser 
            340                 345                 350         


Leu Pro Ser Gly Asp Ala Phe Ser Ser Val Gly Xaa His Arg Phe Val 
        355                 360                 365             


Gln Lys Val Glu Glu Met Val Gln Asn His Met Xaa Tyr Ser Leu Gln 
    370                 375                 380                 


Asp Val Gly Gly Asp Ala Asn Trp Gln Leu Val Val Glu Glu Gly Glu 
385                 390                 395                 400 


Met Lys Val Tyr Arg Arg Glu Val Glu Glu Asn Gly Ile Val Leu Asp 
                405                 410                 415     


Pro Leu Lys Ala Xaa His Ala Val Lys Gly Val Xaa Gly His Glu Val 
            420                 425                 430         


Cys Asn Tyr Phe Trp Asn Val Asp Val Arg Asn Asp Trp Glu Xaa Xaa 
        435                 440                 445             


Ile Glu Asn Phe His Val Val Glu Xaa Leu Ala Asp Asn Ala Ile Ile 
    450                 455                 460                 


Ile Tyr Gln Xaa His Lys Arg Val Trp Pro Ala Ser Gln Arg Asp Val 
465                 470                 475                 480 


Leu Tyr Leu Ser Val Ile Arg Lys Ile Pro Ala Leu Xaa Glu Asn Asp 
                485                 490                 495     


Pro Glu Xaa Trp Ile Val Cys Asn Phe Ser Val Asp His Asp Ser Ala 
            500                 505                 510         


Pro Leu Asn Asn Arg Cys Val Arg Ala Lys Ile Asn Val Ala Met Ile 
        515                 520                 525             


Cys Gln Xaa Leu Val Ser Pro Pro Glu Gly Asn Gln Glu Ile Ser Arg 
    530                 535                 540                 


Asp Asn Ile Leu Cys Lys Ile Xaa Tyr Val Ala Asn Val Asn Pro Gly 
545                 550                 555                 560 


Gly Trp Ala Pro Ala Ser Val Leu Arg Ala Val Ala Lys Arg Glu Tyr 
                565                 570                 575     


Pro Lys Phe Leu Lys Arg Phe Xaa Ser Tyr Val Gln Glu Lys Xaa Ala 
            580                 585                 590         


Gly Lys Pro Ile Leu Phe 
        595             


<210> 6663
<211> 624
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<400> 6663
Met Ser Asp Asn Gln Ser Trp Asn Ser Ser Gly Ser Glu Glu Asp Pro 
1               5                   10                  15      


Glu Xaa Glu Ser Gly Pro Pro Val Glu Arg Cys Gly Val Leu Ser Lys 
            20                  25                  30          


Trp Xaa Asn Tyr Ile His Gly Trp Gln Asp Arg Trp Val Val Leu Lys 
        35                  40                  45              


Asn Asn Ala Leu Ser Tyr Tyr Lys Ser Glu Asp Glu Xaa Glu Tyr Gly 
    50                  55                  60                  


Cys Arg Gly Ser Ile Cys Leu Ser Lys Ala Val Ile Xaa Pro His Asp 
65                  70                  75                  80  


Phe Asp Glu Cys Arg Phe Asp Ile Ser Val Asn Asp Ser Val Trp Tyr 
                85                  90                  95      


Leu Arg Ala Gln Asp Pro Asp His Arg Gln Gln Trp Ile Asp Ala Ile 
            100                 105                 110         


Glu Gln His Lys Xaa Glu Ser Gly Tyr Gly Ser Glu Ser Ser Leu Arg 
        115                 120                 125             


Arg His Gly Ser Met Val Ser Leu Val Ser Gly Ala Ser Gly Tyr Ser 
    130                 135                 140                 


Ala Xaa Ser Xaa Ser Ser Phe Lys Lys Gly His Ser Leu Arg Glu Lys 
145                 150                 155                 160 


Leu Ala Glu Met Glu Xaa Phe Arg Asp Ile Leu Cys Arg Gln Val Asp 
                165                 170                 175     


Xaa Leu Gln Lys Tyr Phe Asp Ala Cys Ala Asp Ala Val Ser Lys Asp 
            180                 185                 190         


Glu Leu Gln Arg Asp Lys Val Val Glu Asp Asp Glu Asp Asp Phe Pro 
        195                 200                 205             


Xaa Xaa Arg Ser Asp Gly Asp Phe Leu His Ser Xaa Asn Gly Asn Lys 
    210                 215                 220                 


Glu Lys Leu Phe Pro His Val Xaa Pro Lys Gly Ile Asn Gly Ile Asp 
225                 230                 235                 240 


Phe Lys Gly Glu Ala Ile Xaa Phe Lys Ala Xaa Xaa Ala Gly Ile Leu 
                245                 250                 255     


Ala Xaa Leu Ser His Cys Ile Glu Leu Met Val Lys Arg Glu Asp Ser 
            260                 265                 270         


Trp Gln Lys Arg Leu Asp Lys Glu Xaa Glu Lys Lys Arg Arg Xaa Glu 
        275                 280                 285             


Glu Ala Tyr Lys Asn Ala Met Xaa Glu Leu Lys Lys Lys Ser His Phe 
    290                 295                 300                 


Gly Gly Pro Asp Tyr Glu Glu Gly Pro Asn Ser Leu Ile Asn Glu Glu 
305                 310                 315                 320 


Glu Phe Phe Asp Ala Val Glu Ala Ala Leu Asp Arg Gln Asp Lys Ile 
                325                 330                 335     


Glu Glu Gln Ser Gln Ser Glu Lys Val Arg Leu His Trp Pro Xaa Ser 
            340                 345                 350         


Leu Pro Ser Gly Asp Ala Phe Ser Ser Val Gly Xaa His Arg Phe Val 
        355                 360                 365             


Gln Lys Pro Tyr Ser Arg Ser Ser Ser Met Ser Ser Ile Asp Leu Val 
    370                 375                 380                 


Ser Ala Ser Asp Asp Val His Arg Phe Ser Ser Gln Val Glu Glu Met 
385                 390                 395                 400 


Val Gln Asn His Met Xaa Tyr Ser Leu Gln Asp Val Gly Gly Asp Ala 
                405                 410                 415     


Asn Trp Gln Leu Val Val Glu Glu Gly Glu Met Lys Val Tyr Arg Arg 
            420                 425                 430         


Glu Val Glu Glu Asn Gly Ile Val Leu Asp Pro Leu Lys Ala Xaa His 
        435                 440                 445             


Ala Val Lys Gly Val Xaa Gly His Glu Val Cys Asn Tyr Phe Trp Asn 
    450                 455                 460                 


Val Asp Val Arg Asn Asp Trp Glu Xaa Xaa Ile Glu Asn Phe His Val 
465                 470                 475                 480 


Val Glu Xaa Leu Ala Asp Asn Ala Ile Ile Ile Tyr Gln Xaa His Lys 
                485                 490                 495     


Arg Val Trp Pro Ala Ser Gln Arg Asp Val Leu Tyr Leu Ser Val Ile 
            500                 505                 510         


Arg Lys Ile Pro Ala Leu Xaa Glu Asn Asp Pro Glu Xaa Trp Ile Val 
        515                 520                 525             


Cys Asn Phe Ser Val Asp His Asp Ser Ala Pro Leu Asn Asn Arg Cys 
    530                 535                 540                 


Val Arg Ala Lys Ile Asn Val Ala Met Ile Cys Gln Xaa Leu Val Ser 
545                 550                 555                 560 


Pro Pro Glu Gly Asn Gln Glu Ile Ser Arg Asp Asn Ile Leu Cys Lys 
                565                 570                 575     


Ile Xaa Tyr Val Ala Asn Val Asn Pro Gly Gly Trp Ala Pro Ala Ser 
            580                 585                 590         


Val Leu Arg Ala Val Ala Lys Arg Glu Tyr Pro Lys Phe Leu Lys Arg 
        595                 600                 605             


Phe Xaa Ser Tyr Val Gln Glu Lys Xaa Ala Gly Lys Pro Ile Leu Phe 
    610                 615                 620                 


<210> 6664
<211> 126
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<400> 6664
Xaa Pro Ala Ser Gln Arg Asp Val Leu Tyr Leu Ser Val Ile Arg Lys 
1               5                   10                  15      


Ile Pro Ala Leu Xaa Glu Asn Asp Pro Glu Xaa Trp Ile Val Cys Asn 
            20                  25                  30          


Phe Ser Val Asp His Asp Ser Ala Pro Leu Asn Asn Arg Cys Val Arg 
        35                  40                  45              


Ala Lys Ile Asn Val Ala Met Ile Cys Gln Xaa Leu Val Ser Pro Pro 
    50                  55                  60                  


Glu Gly Asn Gln Glu Ile Ser Arg Asp Asn Ile Leu Cys Lys Ile Xaa 
65                  70                  75                  80  


Tyr Val Ala Asn Val Asn Pro Gly Gly Trp Ala Pro Ala Ser Val Leu 
                85                  90                  95      


Arg Ala Val Ala Lys Arg Glu Tyr Pro Lys Phe Leu Lys Arg Phe Xaa 
            100                 105                 110         


Ser Tyr Val Gln Glu Lys Xaa Ala Gly Lys Pro Ile Leu Phe 
        115                 120                 125     


<210> 6665
<211> 234
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<400> 6665
Xaa Arg Phe Val Gln Lys Val Glu Glu Met Val Gln Asn His Met Xaa 
1               5                   10                  15      


Tyr Ser Leu Gln Asp Val Gly Gly Asp Ala Asn Trp Gln Leu Val Val 
            20                  25                  30          


Glu Glu Gly Glu Met Lys Val Tyr Arg Arg Glu Val Glu Glu Asn Gly 
        35                  40                  45              


Ile Val Leu Asp Pro Leu Lys Ala Xaa His Ala Val Lys Gly Val Xaa 
    50                  55                  60                  


Gly His Glu Val Cys Asn Tyr Phe Trp Asn Val Asp Val Arg Asn Asp 
65                  70                  75                  80  


Trp Glu Xaa Xaa Ile Glu Asn Phe His Val Val Glu Xaa Leu Ala Asp 
                85                  90                  95      


Asn Ala Ile Ile Ile Tyr Gln Xaa His Lys Arg Val Trp Pro Ala Ser 
            100                 105                 110         


Gln Arg Asp Val Leu Tyr Leu Ser Val Ile Arg Lys Ile Pro Ala Leu 
        115                 120                 125             


Xaa Glu Asn Asp Pro Glu Xaa Trp Ile Val Cys Asn Phe Ser Val Asp 
    130                 135                 140                 


His Asp Ser Ala Pro Leu Asn Asn Arg Cys Val Arg Ala Lys Ile Asn 
145                 150                 155                 160 


Val Ala Met Ile Cys Gln Xaa Leu Val Ser Pro Pro Glu Gly Asn Gln 
                165                 170                 175     


Glu Ile Ser Arg Asp Asn Ile Leu Cys Lys Ile Xaa Tyr Val Ala Asn 
            180                 185                 190         


Val Asn Pro Gly Gly Trp Ala Pro Ala Ser Val Leu Arg Ala Val Ala 
        195                 200                 205             


Lys Arg Glu Tyr Pro Lys Phe Leu Lys Arg Phe Xaa Ser Tyr Val Gln 
    210                 215                 220                 


Glu Lys Xaa Ala Gly Lys Pro Ile Leu Phe 
225                 230                 


<210> 6666
<211> 73
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 6666
Phe Ala Ser Arg Asn Asp Tyr Ser Tyr Trp Leu Ser Xaa Pro Glu Pro 
1               5                   10                  15      


Met Pro Met Ser Met Gln Pro Leu Lys Gly Gln Ser Ile Gln Pro Phe 
            20                  25                  30          


Ile Ser Arg Cys Ala Val Cys Glu Ala Pro Ala Val Val Ile Ala Val 
        35                  40                  45              


His Ser Gln Xaa Ile Gln Ile Pro His Cys Pro Gln Gly Trp Asp Ser 
    50                  55                  60                  


Leu Trp Ile Gly Tyr Ser Phe Met Met 
65                  70              


<210> 6667
<211> 1685
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1402)..(1402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1434)..(1434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1455)..(1455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1465)..(1465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1470)..(1471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1480)..(1480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1505)..(1505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1515)..(1515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1541)..(1541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1580)..(1580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1603)..(1603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1637)..(1637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1651)..(1651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1665)..(1665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1673)..(1673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1685)..(1685)
<223> Selenocysteine

<400> 6667
Met Lys Leu Arg Gly Val Ser Leu Ala Ala Gly Leu Phe Leu Leu Ala 
1               5                   10                  15      


Leu Ser Leu Trp Gly Gln Pro Ala Glu Ala Ala Ala Cys Tyr Gly Cys 
            20                  25                  30          


Ser Pro Gly Ser Lys Cys Asp Cys Ser Gly Ile Lys Gly Glu Lys Gly 
        35                  40                  45              


Glu Arg Gly Phe Pro Gly Leu Glu Gly His Pro Gly Leu Pro Gly Phe 
    50                  55                  60                  


Pro Gly Pro Glu Gly Pro Pro Gly Pro Arg Gly Gln Lys Gly Asp Asp 
65                  70                  75                  80  


Gly Ile Pro Gly Pro Pro Gly Pro Lys Gly Ile Arg Gly Pro Pro Gly 
                85                  90                  95      


Leu Pro Gly Phe Pro Gly Xaa Pro Gly Leu Pro Gly Met Pro Gly His 
            100                 105                 110         


Asp Gly Ala Pro Gly Pro Gln Gly Ile Pro Gly Cys Asn Gly Xaa Lys 
        115                 120                 125             


Gly Glu Arg Gly Phe Pro Gly Ser Pro Gly Phe Pro Gly Leu Gln Gly 
    130                 135                 140                 


Pro Pro Gly Pro Pro Gly Ile Pro Gly Met Lys Gly Glu Pro Gly Ser 
145                 150                 155                 160 


Ile Ile Met Ser Ser Leu Pro Gly Pro Lys Gly Asn Pro Gly Tyr Pro 
                165                 170                 175     


Gly Pro Pro Gly Ile Gln Gly Leu Pro Gly Pro Xaa Gly Ile Pro Gly 
            180                 185                 190         


Pro Ile Gly Pro Pro Gly Pro Pro Gly Leu Met Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Leu Pro Gly Pro Lys Gly Asn Met Gly Leu Asn Phe Gln Gly 
    210                 215                 220                 


Pro Lys Gly Glu Lys Gly Glu Gln Gly Leu Gln Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Gln Ile Ser Glu Gln Lys Arg Pro Ile Asp Val Glu Phe Gln 
                245                 250                 255     


Lys Gly Asp Gln Gly Leu Pro Gly Asp Arg Gly Pro Pro Gly Pro Pro 
            260                 265                 270         


Gly Ile Arg Gly Pro Pro Gly Pro Pro Gly Gly Glu Lys Gly Glu Lys 
        275                 280                 285             


Gly Glu Gln Gly Glu Pro Gly Lys Arg Gly Lys Pro Gly Lys Asp Gly 
    290                 295                 300                 


Glu Asn Gly Gln Pro Gly Ile Pro Gly Leu Pro Gly Asp Pro Gly Tyr 
305                 310                 315                 320 


Pro Gly Glu Pro Gly Arg Asp Gly Glu Lys Gly Gln Lys Gly Asp Xaa 
                325                 330                 335     


Gly Pro Pro Gly Pro Pro Gly Leu Val Ile Pro Arg Pro Gly Xaa Gly 
            340                 345                 350         


Ile Xaa Ile Gly Glu Lys Gly Asn Ile Gly Leu Pro Gly Leu Pro Gly 
        355                 360                 365             


Glu Lys Gly Glu Arg Gly Phe Pro Gly Ile Gln Gly Pro Pro Gly Leu 
    370                 375                 380                 


Pro Gly Pro Pro Gly Ala Ala Val Met Gly Pro Pro Gly Pro Pro Gly 
385                 390                 395                 400 


Phe Pro Gly Glu Arg Gly Gln Lys Gly Asp Glu Gly Pro Pro Gly Ile 
                405                 410                 415     


Ser Ile Pro Gly Pro Pro Gly Leu Asp Gly Gln Pro Gly Ala Pro Gly 
            420                 425                 430         


Leu Pro Gly Pro Pro Gly Pro Ala Gly Pro His Ile Pro Pro Ser Asp 
        435                 440                 445             


Glu Ile Cys Glu Pro Gly Pro Pro Gly Pro Pro Gly Ser Pro Gly Asp 
    450                 455                 460                 


Lys Gly Leu Gln Gly Glu Gln Gly Val Lys Gly Asp Lys Gly Asp Xaa 
465                 470                 475                 480 


Cys Phe Asn Cys Ile Gly Xaa Gly Ile Ser Gly Pro Pro Gly Gln Pro 
                485                 490                 495     


Gly Leu Pro Gly Leu Pro Gly Pro Pro Gly Ser Leu Gly Phe Pro Gly 
            500                 505                 510         


Gln Lys Gly Glu Lys Gly Gln Ala Gly Ala Xaa Gly Pro Lys Gly Leu 
        515                 520                 525             


Pro Gly Ile Pro Gly Ala Pro Gly Ala Pro Gly Phe Pro Gly Ser Lys 
    530                 535                 540                 


Gly Glu Pro Gly Asp Ile Leu Xaa Phe Pro Gly Met Lys Gly Asp Lys 
545                 550                 555                 560 


Gly Glu Leu Gly Ser Pro Gly Ala Pro Gly Leu Pro Gly Leu Pro Gly 
                565                 570                 575     


Xaa Pro Gly Gln Asp Gly Leu Pro Gly Leu Pro Gly Pro Lys Gly Glu 
            580                 585                 590         


Pro Gly Gly Ile Xaa Phe Lys Gly Glu Arg Gly Pro Pro Gly Asn Pro 
        595                 600                 605             


Gly Leu Pro Gly Leu Pro Gly Asn Ile Gly Pro Met Gly Pro Pro Gly 
    610                 615                 620                 


Phe Gly Pro Pro Gly Pro Val Gly Glu Lys Gly Ile Gln Gly Val Ala 
625                 630                 635                 640 


Gly Asn Pro Gly Gln Pro Gly Ile Pro Gly Pro Lys Gly Asp Pro Gly 
                645                 650                 655     


Gln Xaa Ile Xaa Gln Pro Gly Lys Pro Gly Leu Pro Gly Asn Pro Gly 
            660                 665                 670         


Arg Asp Gly Asp Val Gly Leu Pro Gly Asp Pro Gly Leu Pro Gly Gln 
        675                 680                 685             


Pro Gly Leu Pro Gly Ile Pro Gly Ser Lys Gly Glu Pro Gly Ile Pro 
    690                 695                 700                 


Gly Ile Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Phe Pro Gly Ile 
705                 710                 715                 720 


Pro Gly Pro Pro Gly Ala Pro Gly Xaa Pro Gly Arg Ile Gly Leu Glu 
                725                 730                 735     


Gly Pro Pro Gly Pro Pro Gly Phe Pro Gly Pro Lys Gly Glu Pro Gly 
            740                 745                 750         


Phe Ala Leu Pro Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly Phe Lys 
        755                 760                 765             


Gly Ala Leu Gly Pro Lys Gly Asp Arg Gly Phe Pro Gly Pro Pro Gly 
    770                 775                 780                 


Pro Pro Gly Arg Xaa Gly Leu Asp Gly Leu Pro Gly Pro Lys Gly Asp 
785                 790                 795                 800 


Val Gly Pro Asn Gly Gln Pro Gly Pro Met Gly Pro Pro Gly Leu Pro 
                805                 810                 815     


Gly Ile Gly Val Gln Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Pro 
            820                 825                 830         


Ile Gly Gln Pro Gly Leu His Gly Ile Pro Gly Glu Lys Gly Asp Pro 
        835                 840                 845             


Gly Pro Pro Gly Leu Asp Val Pro Gly Pro Pro Gly Glu Arg Gly Ser 
    850                 855                 860                 


Pro Gly Ile Pro Gly Ala Pro Gly Pro Ile Gly Pro Pro Gly Ser Pro 
865                 870                 875                 880 


Gly Leu Pro Gly Lys Ala Gly Ala Ser Gly Phe Pro Gly Xaa Lys Gly 
                885                 890                 895     


Glu Met Gly Met Met Gly Pro Pro Gly Pro Pro Gly Pro Leu Gly Ile 
            900                 905                 910         


Pro Gly Arg Ser Gly Val Pro Gly Leu Lys Gly Asp Asp Gly Leu Gln 
        915                 920                 925             


Gly Gln Pro Gly Leu Pro Gly Pro Xaa Gly Glu Lys Gly Ser Lys Gly 
    930                 935                 940                 


Glu Pro Gly Leu Pro Gly Pro Pro Gly Pro Met Asp Pro Asn Leu Leu 
945                 950                 955                 960 


Gly Ser Lys Gly Glu Lys Gly Glu Pro Gly Leu Pro Gly Ile Pro Gly 
                965                 970                 975     


Val Ser Gly Pro Lys Gly Tyr Gln Gly Leu Pro Gly Asp Pro Gly Gln 
            980                 985                 990         


Pro Gly Leu Ser Gly Gln Pro Gly  Leu Pro Gly Pro Pro  Gly Pro Lys 
        995                 1000                 1005             


Gly Asn  Pro Gly Leu Pro Gly  Gln Pro Gly Leu Ile  Gly Pro Pro 
    1010                 1015                 1020             


Gly Leu  Lys Gly Xaa Ile Gly  Asp Met Gly Phe Pro  Gly Pro Gln 
    1025                 1030                 1035             


Gly Val  Glu Gly Pro Pro Gly  Pro Ser Gly Val Pro  Gly Gln Pro 
    1040                 1045                 1050             


Gly Ser  Pro Gly Leu Pro Gly  Gln Lys Gly Asp Lys  Gly Asp Pro 
    1055                 1060                 1065             


Gly Ile  Ser Ser Ile Gly Leu  Pro Gly Leu Pro Gly  Pro Lys Gly 
    1070                 1075                 1080             


Glu Pro  Gly Leu Pro Gly Tyr  Pro Gly Asn Pro Gly  Ile Lys Gly 
    1085                 1090                 1095             


Ser Val  Gly Asp Pro Gly Leu  Pro Gly Leu Pro Gly  Xaa Pro Gly 
    1100                 1105                 1110             


Ala Lys  Gly Gln Pro Gly Leu  Pro Gly Phe Pro Gly  Xaa Pro Gly 
    1115                 1120                 1125             


Pro Pro  Gly Pro Lys Gly Ile  Ser Gly Pro Pro Gly  Asn Pro Gly 
    1130                 1135                 1140             


Leu Pro  Gly Glu Pro Gly Pro  Val Gly Gly Gly Gly  His Pro Gly 
    1145                 1150                 1155             


Gln Pro  Gly Pro Pro Gly Glu  Lys Gly Lys Pro Gly  Gln Asp Gly 
    1160                 1165                 1170             


Ile Pro  Gly Pro Ala Gly Gln  Lys Gly Glu Pro Gly  Gln Pro Gly 
    1175                 1180                 1185             


Phe Gly  Asn Pro Gly Pro Pro  Gly Leu Pro Gly Leu  Ser Gly Gln 
    1190                 1195                 1200             


Lys Gly  Asp Gly Gly Leu Pro  Gly Ile Pro Gly Asn  Pro Gly Leu 
    1205                 1210                 1215             


Pro Gly  Pro Lys Gly Glu Pro  Gly Phe His Gly Phe  Pro Gly Val 
    1220                 1225                 1230             


Gln Gly  Pro Pro Gly Pro Pro  Gly Ser Pro Gly Pro  Ala Leu Glu 
    1235                 1240                 1245             


Gly Pro  Lys Gly Asn Pro Gly  Pro Gln Gly Pro Pro  Gly Arg Pro 
    1250                 1255                 1260             


Gly Leu  Pro Gly Pro Glu Gly  Pro Pro Gly Leu Pro  Gly Asn Gly 
    1265                 1270                 1275             


Gly Ile  Lys Gly Glu Lys Gly  Asn Pro Gly Gln Pro  Gly Leu Pro 
    1280                 1285                 1290             


Gly Leu  Pro Gly Leu Lys Gly  Asp Gln Gly Pro Pro  Gly Leu Gln 
    1295                 1300                 1305             


Gly Asn  Pro Gly Arg Pro Gly  Leu Asn Gly Met Lys  Gly Asp Pro 
    1310                 1315                 1320             


Gly Leu  Pro Gly Val Pro Gly  Phe Pro Gly Met Lys  Gly Pro Ser 
    1325                 1330                 1335             


Gly Val  Pro Gly Ser Ala Gly  Pro Glu Gly Glu Pro  Gly Leu Ile 
    1340                 1345                 1350             


Gly Pro  Pro Gly Pro Pro Gly  Leu Pro Gly Pro Ser  Gly Gln Ser 
    1355                 1360                 1365             


Ile Ile  Ile Lys Gly Asp Ala  Gly Pro Pro Gly Ile  Pro Gly Gln 
    1370                 1375                 1380             


Pro Gly  Leu Lys Gly Leu Pro  Gly Pro Gln Gly Pro  Gln Gly Leu 
    1385                 1390                 1395             


Pro Gly  Pro Xaa Gly Pro Pro  Gly Asp Pro Gly Arg  Asn Gly Leu 
    1400                 1405                 1410             


Pro Gly  Phe Asp Gly Ala Gly  Gly Arg Lys Gly Asp  Pro Gly Leu 
    1415                 1420                 1425             


Pro Gly  Gln Pro Gly Xaa Arg  Gly Leu Asp Gly Pro  Pro Gly Pro 
    1430                 1435                 1440             


Asp Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Xaa  Ser Ser Val 
    1445                 1450                 1455             


Ala His  Gly Phe Leu Ile Xaa  Arg His Ser Gln Xaa  Xaa Asp Ala 
    1460                 1465                 1470             


Pro Gln  Cys Pro Gln Gly Xaa  Leu Gln Val Tyr Glu  Gly Phe Ser 
    1475                 1480                 1485             


Leu Leu  Tyr Val Gln Gly Asn  Lys Arg Ala His Gly  Gln Asp Leu 
    1490                 1495                 1500             


Gly Xaa  Ala Gly Ser Cys Leu  Arg Arg Phe Ser Xaa  Met Pro Phe 
    1505                 1510                 1515             


Met Phe  Cys Asn Ile Asn Asn  Val Cys Asn Phe Ala  Ser Arg Asn 
    1520                 1525                 1530             


Asp Tyr  Ser Tyr Trp Leu Ser  Xaa Pro Glu Pro Met  Pro Met Ser 
    1535                 1540                 1545             


Met Gln  Pro Leu Lys Gly Gln  Ser Ile Gln Pro Phe  Ile Ser Arg 
    1550                 1555                 1560             


Cys Ala  Val Cys Glu Ala Pro  Ala Val Val Ile Ala  Val His Ser 
    1565                 1570                 1575             


Gln Xaa  Ile Gln Ile Pro His  Cys Pro Gln Gly Trp  Asp Ser Leu 
    1580                 1585                 1590             


Trp Ile  Gly Tyr Ser Phe Met  Met His Xaa Ser Ala  Gly Ala Glu 
    1595                 1600                 1605             


Gly Ser  Gly Gln Ala Leu Ala  Ser Pro Gly Ser Cys  Leu Glu Glu 
    1610                 1615                 1620             


Phe Arg  Ser Ala Pro Phe Ile  Glu Cys His Gly Arg  Gly Xaa Cys 
    1625                 1630                 1635             


Asn Tyr  Tyr Ala Asn Ser Tyr  Ser Phe Trp Leu Ala  Xaa Val Asp 
    1640                 1645                 1650             


Val Ser  Asp Met Phe Ser Lys  Pro Gln Ser Glu Xaa  Leu Lys Ala 
    1655                 1660                 1665             


Gly Asp  Leu Arg Xaa Arg Ile  Ser Arg Cys Gln Val  Cys Met Lys 
    1670                 1675                 1680             


Arg Xaa  
    1685 


<210> 6668
<211> 1691
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1126)..(1126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1440)..(1440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1461)..(1461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1471)..(1471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1476)..(1477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1486)..(1486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1511)..(1511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1521)..(1521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1609)..(1609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1643)..(1643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1657)..(1657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1671)..(1671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1679)..(1679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1691)..(1691)
<223> Selenocysteine

<400> 6668
Met Lys Leu Arg Gly Val Ser Leu Ala Ala Gly Leu Phe Leu Leu Ala 
1               5                   10                  15      


Leu Ser Leu Trp Gly Gln Pro Ala Glu Ala Ala Ala Cys Tyr Gly Cys 
            20                  25                  30          


Ser Pro Gly Ser Lys Cys Asp Cys Ser Gly Ile Lys Gly Glu Lys Gly 
        35                  40                  45              


Glu Arg Gly Phe Pro Gly Leu Glu Gly His Pro Gly Leu Pro Gly Phe 
    50                  55                  60                  


Pro Gly Pro Glu Gly Pro Pro Gly Pro Arg Gly Gln Lys Gly Asp Asp 
65                  70                  75                  80  


Gly Ile Pro Gly Pro Pro Gly Pro Lys Gly Ile Arg Gly Pro Pro Gly 
                85                  90                  95      


Leu Pro Gly Phe Pro Gly Xaa Pro Gly Leu Pro Gly Met Pro Gly His 
            100                 105                 110         


Asp Gly Ala Pro Gly Pro Gln Gly Ile Pro Gly Cys Asn Gly Xaa Lys 
        115                 120                 125             


Gly Glu Arg Gly Phe Pro Gly Ser Pro Gly Phe Pro Gly Leu Gln Gly 
    130                 135                 140                 


Pro Pro Gly Pro Pro Gly Ile Pro Gly Met Lys Gly Glu Pro Gly Ser 
145                 150                 155                 160 


Ile Ile Met Ser Ser Leu Pro Gly Pro Lys Gly Asn Pro Gly Tyr Pro 
                165                 170                 175     


Gly Pro Pro Gly Ile Gln Gly Leu Pro Gly Pro Xaa Gly Ile Pro Gly 
            180                 185                 190         


Pro Ile Gly Pro Pro Gly Pro Pro Gly Leu Met Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Leu Pro Gly Pro Lys Gly Asn Met Gly Leu Asn Phe Gln Gly 
    210                 215                 220                 


Pro Lys Gly Glu Lys Gly Glu Gln Gly Leu Gln Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Gln Ile Ser Glu Gln Lys Arg Pro Ile Asp Val Glu Phe Gln 
                245                 250                 255     


Lys Gly Asp Gln Gly Leu Pro Gly Asp Arg Gly Pro Pro Gly Pro Pro 
            260                 265                 270         


Gly Ile Arg Gly Pro Pro Gly Pro Pro Gly Gly Glu Lys Gly Glu Lys 
        275                 280                 285             


Gly Glu Gln Gly Glu Pro Gly Lys Arg Gly Lys Pro Gly Lys Asp Gly 
    290                 295                 300                 


Glu Asn Gly Gln Pro Gly Ile Pro Gly Leu Pro Gly Asp Pro Gly Tyr 
305                 310                 315                 320 


Pro Gly Glu Pro Gly Arg Asp Gly Glu Lys Gly Gln Lys Gly Asp Xaa 
                325                 330                 335     


Gly Pro Pro Gly Pro Pro Gly Leu Val Ile Pro Arg Pro Gly Xaa Gly 
            340                 345                 350         


Ile Xaa Ile Gly Glu Lys Gly Asn Ile Gly Leu Pro Gly Leu Pro Gly 
        355                 360                 365             


Glu Lys Gly Glu Arg Gly Phe Pro Gly Ile Gln Gly Pro Pro Gly Leu 
    370                 375                 380                 


Pro Gly Pro Pro Gly Ala Ala Val Met Gly Pro Pro Gly Pro Pro Gly 
385                 390                 395                 400 


Phe Pro Gly Glu Arg Gly Gln Lys Gly Asp Glu Gly Pro Pro Gly Ile 
                405                 410                 415     


Ser Ile Pro Gly Pro Pro Gly Leu Asp Gly Gln Pro Gly Ala Pro Gly 
            420                 425                 430         


Leu Pro Gly Pro Pro Gly Pro Ala Gly Pro His Ile Pro Pro Ser Asp 
        435                 440                 445             


Glu Ile Cys Glu Pro Gly Pro Pro Gly Pro Pro Gly Ser Pro Gly Asp 
    450                 455                 460                 


Lys Gly Leu Gln Gly Glu Gln Gly Val Lys Gly Asp Lys Gly Asp Xaa 
465                 470                 475                 480 


Cys Phe Asn Cys Ile Gly Xaa Gly Ile Ser Gly Pro Pro Gly Gln Pro 
                485                 490                 495     


Gly Leu Pro Gly Leu Pro Gly Pro Pro Gly Ser Leu Gly Phe Pro Gly 
            500                 505                 510         


Gln Lys Gly Glu Lys Gly Gln Ala Gly Ala Xaa Gly Pro Lys Gly Leu 
        515                 520                 525             


Pro Gly Ile Pro Gly Ala Pro Gly Ala Pro Gly Phe Pro Gly Ser Lys 
    530                 535                 540                 


Gly Glu Pro Gly Asp Ile Leu Xaa Phe Pro Gly Met Lys Gly Asp Lys 
545                 550                 555                 560 


Gly Glu Leu Gly Ser Pro Gly Ala Pro Gly Leu Pro Gly Leu Pro Gly 
                565                 570                 575     


Xaa Pro Gly Gln Asp Gly Leu Pro Gly Leu Pro Gly Pro Lys Gly Glu 
            580                 585                 590         


Pro Gly Gly Ile Xaa Phe Lys Gly Glu Arg Gly Pro Pro Gly Asn Pro 
        595                 600                 605             


Gly Leu Pro Gly Leu Pro Gly Asn Ile Gly Pro Met Gly Pro Pro Gly 
    610                 615                 620                 


Phe Gly Pro Pro Gly Pro Val Gly Glu Lys Gly Ile Gln Gly Val Ala 
625                 630                 635                 640 


Gly Asn Pro Gly Gln Pro Gly Ile Pro Gly Pro Lys Gly Asp Pro Gly 
                645                 650                 655     


Gln Xaa Ile Xaa Gln Pro Gly Lys Pro Gly Leu Pro Gly Asn Pro Gly 
            660                 665                 670         


Arg Asp Gly Asp Val Gly Leu Pro Gly Asp Pro Gly Leu Pro Gly Gln 
        675                 680                 685             


Pro Gly Leu Pro Gly Ile Pro Gly Ser Lys Gly Glu Pro Gly Ile Pro 
    690                 695                 700                 


Gly Ile Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Phe Pro Gly Ile 
705                 710                 715                 720 


Pro Gly Pro Pro Gly Ala Pro Gly Xaa Pro Gly Arg Ile Gly Leu Glu 
                725                 730                 735     


Gly Pro Pro Gly Pro Pro Gly Phe Pro Gly Pro Lys Gly Glu Pro Gly 
            740                 745                 750         


Phe Ala Leu Pro Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly Phe Lys 
        755                 760                 765             


Gly Ala Leu Gly Pro Lys Gly Asp Arg Gly Phe Pro Gly Pro Pro Gly 
    770                 775                 780                 


Pro Pro Gly Arg Xaa Gly Leu Asp Gly Leu Pro Gly Pro Lys Gly Asp 
785                 790                 795                 800 


Val Gly Pro Asn Gly Gln Pro Gly Pro Met Gly Pro Pro Gly Leu Pro 
                805                 810                 815     


Gly Ile Gly Val Gln Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Pro 
            820                 825                 830         


Ile Gly Gln Pro Gly Leu His Gly Ile Pro Gly Glu Lys Gly Asp Pro 
        835                 840                 845             


Gly Pro Pro Gly Leu Asp Val Pro Gly Pro Pro Gly Glu Arg Gly Ser 
    850                 855                 860                 


Pro Gly Ile Pro Gly Ala Pro Gly Pro Ile Gly Pro Pro Gly Ser Pro 
865                 870                 875                 880 


Gly Leu Pro Gly Lys Ala Gly Ala Ser Gly Phe Pro Gly Xaa Lys Gly 
                885                 890                 895     


Glu Met Gly Met Met Gly Pro Pro Gly Pro Pro Gly Pro Leu Gly Ile 
            900                 905                 910         


Pro Gly Arg Ser Gly Val Pro Gly Leu Lys Gly Asp Asp Gly Leu Gln 
        915                 920                 925             


Gly Gln Pro Gly Leu Pro Gly Pro Xaa Gly Glu Lys Gly Ser Lys Gly 
    930                 935                 940                 


Glu Pro Gly Leu Pro Gly Pro Pro Gly Pro Met Asp Pro Asn Leu Leu 
945                 950                 955                 960 


Gly Ser Lys Gly Glu Lys Gly Glu Pro Gly Leu Pro Gly Ile Pro Gly 
                965                 970                 975     


Val Ser Gly Pro Lys Gly Tyr Gln Gly Leu Pro Gly Asp Pro Gly Gln 
            980                 985                 990         


Pro Gly Leu Ser Gly Gln Pro Gly  Leu Pro Gly Pro Pro  Gly Pro Lys 
        995                 1000                 1005             


Gly Asn  Pro Gly Leu Pro Gly  Gln Pro Gly Leu Ile  Gly Pro Pro 
    1010                 1015                 1020             


Gly Leu  Lys Gly Xaa Ile Gly  Asp Met Gly Phe Pro  Gly Pro Gln 
    1025                 1030                 1035             


Gly Val  Glu Gly Pro Pro Gly  Pro Ser Gly Val Pro  Gly Gln Pro 
    1040                 1045                 1050             


Gly Ser  Pro Gly Leu Pro Gly  Gln Lys Gly Asp Lys  Gly Asp Pro 
    1055                 1060                 1065             


Gly Ile  Ser Ser Ile Gly Leu  Pro Gly Leu Pro Gly  Pro Lys Gly 
    1070                 1075                 1080             


Glu Pro  Gly Leu Pro Gly Tyr  Pro Gly Asn Pro Gly  Ile Lys Gly 
    1085                 1090                 1095             


Ser Val  Gly Asp Pro Gly Leu  Pro Gly Leu Pro Gly  Xaa Pro Gly 
    1100                 1105                 1110             


Ala Lys  Gly Gln Pro Gly Leu  Pro Gly Phe Pro Gly  Xaa Pro Gly 
    1115                 1120                 1125             


Pro Pro  Gly Pro Lys Gly Ile  Ser Gly Pro Pro Gly  Asn Pro Gly 
    1130                 1135                 1140             


Leu Pro  Gly Glu Pro Gly Pro  Val Gly Gly Gly Gly  His Pro Gly 
    1145                 1150                 1155             


Gln Pro  Gly Pro Pro Gly Glu  Lys Gly Lys Pro Gly  Gln Asp Gly 
    1160                 1165                 1170             


Ile Pro  Gly Pro Ala Gly Gln  Lys Gly Glu Pro Gly  Gln Pro Gly 
    1175                 1180                 1185             


Phe Gly  Asn Pro Gly Pro Pro  Gly Leu Pro Gly Leu  Ser Gly Gln 
    1190                 1195                 1200             


Lys Gly  Asp Gly Gly Leu Pro  Gly Ile Pro Gly Asn  Pro Gly Leu 
    1205                 1210                 1215             


Pro Gly  Pro Lys Gly Glu Pro  Gly Phe His Gly Phe  Pro Gly Val 
    1220                 1225                 1230             


Gln Gly  Pro Pro Gly Pro Pro  Gly Ser Pro Gly Pro  Ala Leu Glu 
    1235                 1240                 1245             


Gly Pro  Lys Gly Asn Pro Gly  Pro Gln Gly Pro Pro  Gly Arg Pro 
    1250                 1255                 1260             


Gly Pro  Xaa Gly Phe Gln Gly  Leu Pro Gly Pro Glu  Gly Pro Pro 
    1265                 1270                 1275             


Gly Leu  Pro Gly Asn Gly Gly  Ile Lys Gly Glu Lys  Gly Asn Pro 
    1280                 1285                 1290             


Gly Gln  Pro Gly Leu Pro Gly  Leu Pro Gly Leu Lys  Gly Asp Gln 
    1295                 1300                 1305             


Gly Pro  Pro Gly Leu Gln Gly  Asn Pro Gly Arg Pro  Gly Leu Asn 
    1310                 1315                 1320             


Gly Met  Lys Gly Asp Pro Gly  Leu Pro Gly Val Pro  Gly Phe Pro 
    1325                 1330                 1335             


Gly Met  Lys Gly Pro Ser Gly  Val Pro Gly Ser Ala  Gly Pro Glu 
    1340                 1345                 1350             


Gly Glu  Pro Gly Leu Ile Gly  Pro Pro Gly Pro Pro  Gly Leu Pro 
    1355                 1360                 1365             


Gly Pro  Ser Gly Gln Ser Ile  Ile Ile Lys Gly Asp  Ala Gly Pro 
    1370                 1375                 1380             


Pro Gly  Ile Pro Gly Gln Pro  Gly Leu Lys Gly Leu  Pro Gly Pro 
    1385                 1390                 1395             


Gln Gly  Pro Gln Gly Leu Pro  Gly Pro Xaa Gly Pro  Pro Gly Asp 
    1400                 1405                 1410             


Pro Gly  Arg Asn Gly Leu Pro  Gly Phe Asp Gly Ala  Gly Gly Arg 
    1415                 1420                 1425             


Lys Gly  Asp Pro Gly Leu Pro  Gly Gln Pro Gly Xaa  Arg Gly Leu 
    1430                 1435                 1440             


Asp Gly  Pro Pro Gly Pro Asp  Gly Leu Gln Gly Pro  Pro Gly Pro 
    1445                 1450                 1455             


Pro Gly  Xaa Ser Ser Val Ala  His Gly Phe Leu Ile  Xaa Arg His 
    1460                 1465                 1470             


Ser Gln  Xaa Xaa Asp Ala Pro  Gln Cys Pro Gln Gly  Xaa Leu Gln 
    1475                 1480                 1485             


Val Tyr  Glu Gly Phe Ser Leu  Leu Tyr Val Gln Gly  Asn Lys Arg 
    1490                 1495                 1500             


Ala His  Gly Gln Asp Leu Gly  Xaa Ala Gly Ser Cys  Leu Arg Arg 
    1505                 1510                 1515             


Phe Ser  Xaa Met Pro Phe Met  Phe Cys Asn Ile Asn  Asn Val Cys 
    1520                 1525                 1530             


Asn Phe  Ala Ser Arg Asn Asp  Tyr Ser Tyr Trp Leu  Ser Xaa Pro 
    1535                 1540                 1545             


Glu Pro  Met Pro Met Ser Met  Gln Pro Leu Lys Gly  Gln Ser Ile 
    1550                 1555                 1560             


Gln Pro  Phe Ile Ser Arg Cys  Ala Val Cys Glu Ala  Pro Ala Val 
    1565                 1570                 1575             


Val Ile  Ala Val His Ser Gln  Xaa Ile Gln Ile Pro  His Cys Pro 
    1580                 1585                 1590             


Gln Gly  Trp Asp Ser Leu Trp  Ile Gly Tyr Ser Phe  Met Met His 
    1595                 1600                 1605             


Xaa Ser  Ala Gly Ala Glu Gly  Ser Gly Gln Ala Leu  Ala Ser Pro 
    1610                 1615                 1620             


Gly Ser  Cys Leu Glu Glu Phe  Arg Ser Ala Pro Phe  Ile Glu Cys 
    1625                 1630                 1635             


His Gly  Arg Gly Xaa Cys Asn  Tyr Tyr Ala Asn Ser  Tyr Ser Phe 
    1640                 1645                 1650             


Trp Leu  Ala Xaa Val Asp Val  Ser Asp Met Phe Ser  Lys Pro Gln 
    1655                 1660                 1665             


Ser Glu  Xaa Leu Lys Ala Gly  Asp Leu Arg Xaa Arg  Ile Ser Arg 
    1670                 1675                 1680             


Cys Gln  Val Cys Met Lys Arg  Xaa 
    1685                 1690     


<210> 6669
<211> 174
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<400> 6669
Xaa Asp Asp Gly Leu Gln Gly Gln Pro Gly Leu Pro Gly Pro Xaa Gly 
1               5                   10                  15      


Glu Lys Gly Ser Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly Pro 
            20                  25                  30          


Met Asp Pro Asn Leu Leu Gly Ser Lys Gly Glu Lys Gly Glu Pro Gly 
        35                  40                  45              


Leu Pro Gly Ile Pro Gly Val Ser Gly Pro Lys Gly Tyr Gln Gly Leu 
    50                  55                  60                  


Pro Gly Asp Pro Gly Gln Pro Gly Leu Ser Gly Gln Pro Gly Leu Pro 
65                  70                  75                  80  


Gly Pro Pro Gly Pro Lys Gly Asn Pro Gly Leu Pro Gly Gln Pro Gly 
                85                  90                  95      


Leu Ile Gly Pro Pro Gly Leu Lys Gly Xaa Ile Gly Asp Met Gly Phe 
            100                 105                 110         


Pro Gly Pro Gln Gly Val Glu Gly Pro Pro Gly Pro Ser Gly Val Pro 
        115                 120                 125             


Gly Gln Pro Gly Ser Pro Gly Leu Pro Gly Gln Lys Gly Asp Lys Gly 
    130                 135                 140                 


Asp Pro Gly Ile Ser Ser Ile Gly Leu Pro Gly Leu Pro Gly Pro Lys 
145                 150                 155                 160 


Met Ile Arg Arg Tyr Val Leu Gly Phe Val Ala Ser Pro Lys 
                165                 170                 


<210> 6670
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<400> 6670
Xaa Gly Leu Pro Gly Pro Xaa Gly Pro Pro Gly Asp Pro Gly Arg Asn 
1               5                   10                  15      


Gly Leu Pro Gly Phe Asp Gly Ala Gly Gly Arg Lys Gly Asp Pro Gly 
            20                  25                  30          


Leu Pro Gly Gln Pro Gly Xaa Arg Gly Leu Asp Gly Pro Pro Gly Pro 
        35                  40                  45              


Asp Gly Leu Gln Gly Pro Pro Gly Pro Pro Gly Xaa Ser Ser Val Ala 
    50                  55                  60                  


His Gly Phe Leu Ile Xaa Arg His Ser Gln Xaa Xaa Asp Ala Pro Gln 
65                  70                  75                  80  


Cys Pro Gln Gly Xaa Leu Gln Val Tyr Glu Gly Phe Ser Leu Leu Tyr 
                85                  90                  95      


Val Gln Gly Asn Lys Arg Ala His Gly Gln Asp Leu Val Asn Leu Ser 
            100                 105                 110         


Gln Lys Arg 
        115 


<210> 6671
<211> 1633
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1311)..(1311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1313)..(1313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1411)..(1411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1463)..(1463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1489)..(1490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1501)..(1501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1528)..(1528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1549)..(1549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1584)..(1584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1597)..(1598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1613)..(1613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1621)..(1621)
<223> Selenocysteine

<400> 6671
Met His Pro Gly Leu Trp Leu Leu Leu Val Xaa Leu Cys Leu Xaa Glu 
1               5                   10                  15      


Glu Leu Ala Ala Ala Gly Glu Lys Ser Tyr Gly Lys Pro Cys Gly Gly 
            20                  25                  30          


Gln Asp Cys Ser Gly Ser Cys Gln Cys Phe Pro Glu Lys Gly Ala Arg 
        35                  40                  45              


Gly Arg Pro Gly Pro Ile Gly Ile Gln Gly Pro Xaa Gly Pro Gln Gly 
    50                  55                  60                  


Phe Xaa Gly Ser Xaa Gly Leu Ser Gly Leu Lys Gly Glu Arg Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Leu Gly Pro Tyr Gly Pro Lys Gly Asp Lys Gly Pro Met 
                85                  90                  95      


Gly Val Pro Gly Phe Leu Gly Ile Asn Gly Ile Pro Gly His Pro Gly 
            100                 105                 110         


Gln Pro Gly Pro Arg Gly Pro Pro Gly Leu Asp Gly Cys Asn Gly Xaa 
        115                 120                 125             


Gln Gly Ala Val Gly Phe Pro Gly Pro Asp Gly Tyr Pro Gly Leu Leu 
    130                 135                 140                 


Gly Pro Pro Gly Leu Pro Gly Gln Lys Gly Ser Lys Gly Asp Pro Val 
145                 150                 155                 160 


Leu Ala Pro Gly Ser Phe Lys Gly Met Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Leu Asp Gly Ile Xaa Gly Pro Gln Gly Ala Pro Gly Phe Pro Gly 
            180                 185                 190         


Ala Val Gly Pro Ala Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Pro Leu Gly Pro Asp Gly Asn Met Gly Leu Gly Phe Gln Gly 
    210                 215                 220                 


Glu Lys Gly Val Lys Gly Asp Val Gly Leu Pro Gly Pro Ala Gly Pro 
225                 230                 235                 240 


Pro Pro Ser Xaa Gly Glu Leu Glu Phe Met Gly Phe Pro Lys Gly Lys 
                245                 250                 255     


Lys Gly Ser Lys Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Ile Ser 
            260                 265                 270         


Gly Pro Pro Gly Phe Pro Gly Leu Gly Xaa Xaa Gly Glu Lys Gly Glu 
        275                 280                 285             


Lys Gly Glu Lys Gly Ile Pro Gly Leu Pro Gly Pro Arg Gly Pro Met 
    290                 295                 300                 


Gly Ser Glu Gly Val Gln Gly Pro Pro Gly Gln Gln Gly Lys Lys Gly 
305                 310                 315                 320 


Xaa Leu Gly Phe Pro Gly Leu Asn Gly Phe Gln Gly Ile Glu Gly Gln 
                325                 330                 335     


Lys Gly Asp Ile Gly Leu Pro Gly Pro Asp Val Phe Ile Asp Ile Asp 
            340                 345                 350         


Gly Ala Val Ile Ser Gly Asn Pro Gly Asp Pro Gly Val Pro Gly Leu 
        355                 360                 365             


Pro Gly Leu Lys Gly Asp Glu Gly Ile Gln Gly Leu Arg Gly Pro Ser 
    370                 375                 380                 


Gly Val Pro Gly Leu Pro Ala Leu Ser Gly Val Pro Gly Ala Leu Gly 
385                 390                 395                 400 


Pro Gln Gly Phe Pro Gly Leu Lys Gly Asp Gln Gly Asn Pro Gly Arg 
                405                 410                 415     


Xaa Xaa Ile Gly Ala Ala Gly Leu Pro Gly Arg Asp Gly Leu Pro Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Pro Pro Ser Pro Glu Phe Glu Xaa Glu Xaa 
        435                 440                 445             


Leu His Asn Lys Glu Ser Gly Phe Pro Gly Leu Arg Gly Glu Gln Gly 
    450                 455                 460                 


Pro Lys Gly Asn Leu Gly Leu Lys Gly Ile Lys Gly Asp Ser Gly Phe 
465                 470                 475                 480 


Cys Ala Cys Asp Gly Gly Val Pro Asn Xaa Gly Pro Pro Gly Glu Pro 
                485                 490                 495     


Gly Pro Pro Gly Pro Trp Gly Leu Ile Gly Leu Pro Gly Leu Lys Gly 
            500                 505                 510         


Ala Arg Gly Asp Arg Gly Ser Gly Gly Ala Gln Gly Pro Ala Gly Ala 
        515                 520                 525             


Pro Gly Leu Val Gly Pro Leu Gly Pro Ser Gly Pro Lys Gly Lys Lys 
    530                 535                 540                 


Gly Glu Pro Ile Leu Ser Xaa Ile Gln Gly Met Pro Gly Asp Arg Gly 
545                 550                 555                 560 


Asp Ser Gly Ser Gln Gly Phe Arg Gly Val Ile Gly Glu Pro Gly Lys 
                565                 570                 575     


Asp Gly Val Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Asp Gly 
            580                 585                 590         


Gly Gln Gly Phe Pro Gly Glu Lys Gly Leu Pro Gly Leu Pro Gly Glu 
        595                 600                 605             


Lys Gly His Pro Gly Pro Pro Gly Leu Pro Gly Asn Gly Leu Pro Gly 
    610                 615                 620                 


Leu Pro Gly Pro Arg Gly Leu Pro Gly Asp Lys Gly Lys Asp Gly Leu 
625                 630                 635                 640 


Pro Gly Gln Gln Gly Leu Pro Gly Ser Lys Gly Ile Xaa Leu Pro Cys 
                645                 650                 655     


Ile Ile Pro Gly Ser Tyr Gly Pro Ser Gly Phe Pro Gly Xaa Pro Gly 
            660                 665                 670         


Phe Pro Gly Pro Lys Gly Ser Arg Gly Leu Pro Gly Xaa Pro Gly Gln 
        675                 680                 685             


Pro Gly Ser Ser Gly Ser Lys Gly Glu Pro Gly Ser Pro Gly Leu Val 
    690                 695                 700                 


His Leu Pro Glu Leu Pro Gly Phe Pro Gly Pro Arg Gly Glu Lys Gly 
705                 710                 715                 720 


Leu Pro Gly Phe Pro Gly Leu Pro Gly Lys Asp Gly Leu Pro Gly Met 
                725                 730                 735     


Ile Gly Ser Pro Gly Leu Pro Gly Ser Lys Gly Ala Xaa Gly Asp Ile 
            740                 745                 750         


Phe Gly Ala Glu Asn Gly Ala Pro Gly Glu Gln Gly Leu Gln Gly Leu 
        755                 760                 765             


Xaa Gly His Lys Gly Phe Leu Gly Asp Ser Gly Leu Pro Gly Leu Lys 
    770                 775                 780                 


Gly Val His Gly Lys Pro Gly Leu Leu Gly Pro Lys Gly Glu Arg Gly 
785                 790                 795                 800 


Ser Pro Gly Xaa Pro Gly Gln Val Gly Gln Pro Gly Xaa Pro Gly Ser 
                805                 810                 815     


Ser Gly Pro Tyr Gly Ile Lys Gly Lys Ser Gly Leu Pro Gly Ala Pro 
            820                 825                 830         


Gly Phe Pro Gly Ile Ser Gly His Pro Gly Lys Lys Gly Xaa Arg Gly 
        835                 840                 845             


Lys Lys Gly Pro Pro Gly Ser Ile Val Lys Lys Gly Leu Pro Gly Leu 
    850                 855                 860                 


Lys Gly Leu Pro Gly Asn Pro Gly Leu Val Gly Leu Lys Gly Ser Pro 
865                 870                 875                 880 


Gly Ser Pro Gly Val Ala Gly Leu Pro Ala Leu Ser Gly Pro Lys Gly 
                885                 890                 895     


Glu Lys Gly Ser Val Gly Phe Val Gly Phe Pro Gly Ile Pro Gly Leu 
            900                 905                 910         


Pro Gly Ile Pro Gly Xaa Arg Gly Leu Lys Gly Ile Pro Gly Ser Xaa 
        915                 920                 925             


Gly Lys Met Gly Pro Ser Gly Arg Ala Gly Xaa Pro Gly Glu Lys Gly 
    930                 935                 940                 


Asp Arg Gly Asn Pro Gly Pro Val Gly Ile Pro Ser Pro Arg Arg Pro 
945                 950                 955                 960 


Met Ser Asn Leu Trp Leu Lys Gly Asp Lys Gly Ser Gln Gly Ser Ala 
                965                 970                 975     


Gly Ser Asn Gly Phe Pro Gly Pro Arg Gly Asp Lys Gly Glu Ala Gly 
            980                 985                 990         


Arg Pro Gly Pro Pro Gly Leu Pro  Gly Ala Pro Gly Leu  Pro Gly Ile 
        995                 1000                 1005             


Ile Lys  Gly Val Ser Gly Lys  Pro Gly Pro Pro Gly  Phe Met Gly 
    1010                 1015                 1020             


Ile Arg  Gly Leu Pro Gly Leu  Lys Gly Ser Ser Gly  Ile Xaa Gly 
    1025                 1030                 1035             


Phe Pro  Gly Met Pro Gly Glu  Ser Gly Ser Gln Gly  Ile Arg Gly 
    1040                 1045                 1050             


Ser Pro  Gly Leu Pro Gly Ala  Ser Gly Leu Pro Gly  Leu Lys Gly 
    1055                 1060                 1065             


Asp Asn  Gly Gln Xaa Val Glu  Ile Ser Gly Ser Pro  Gly Pro Lys 
    1070                 1075                 1080             


Gly Gln  Pro Gly Glu Ser Gly  Phe Lys Gly Xaa Lys  Gly Arg Asp 
    1085                 1090                 1095             


Gly Leu  Ile Gly Asn Ile Gly  Phe Pro Gly Asn Lys  Gly Glu Asp 
    1100                 1105                 1110             


Gly Lys  Val Gly Val Ser Gly  Asp Val Gly Leu Pro  Gly Ala Pro 
    1115                 1120                 1125             


Gly Phe  Pro Gly Val Ala Gly  Met Arg Gly Glu Pro  Gly Leu Pro 
    1130                 1135                 1140             


Gly Ser  Ser Gly His Gln Gly  Ala Ile Gly Pro Leu  Gly Ser Pro 
    1145                 1150                 1155             


Gly Leu  Ile Gly Pro Lys Gly  Pro Ser Ile Xaa Gly  Val Pro Gly 
    1160                 1165                 1170             


Pro Ala  Gly Leu Pro Gly Pro  Lys Gly Glu Lys Gly  Tyr Pro Gly 
    1175                 1180                 1185             


Ile Gly  Ile Gly Ala Pro Gly  Lys Pro Gly Leu Arg  Gly Gln Lys 
    1190                 1195                 1200             


Gly Asp  Arg Gly Phe Pro Gly  Leu Gln Gly Pro Ala  Gly Leu Pro 
    1205                 1210                 1215             


Gly Ala  Pro Gly Ile Ser Leu  Pro Ser Leu Ile Ala  Gly Gln Pro 
    1220                 1225                 1230             


Gly Asp  Pro Gly Arg Pro Gly  Leu Asp Gly Glu Arg  Gly Arg Pro 
    1235                 1240                 1245             


Gly Pro  Ala Gly Pro Pro Gly  Pro Pro Gly Pro Ser  Ser Asn Gln 
    1250                 1255                 1260             


Gly Asp  Xaa Gly Asp Pro Gly  Phe Pro Gly Ile Pro  Gly Pro Lys 
    1265                 1270                 1275             


Gly Pro  Lys Gly Asp Gln Gly  Ile Pro Gly Phe Ser  Gly Leu Pro 
    1280                 1285                 1290             


Gly Glu  Leu Gly Leu Lys Gly  Ser Ser Gly Leu Gln  Gly Asp Pro 
    1295                 1300                 1305             


Gly Gln  Xaa Pro Xaa Ala Glu  Ala Val Gln Val Pro  Pro Gly Pro 
    1310                 1315                 1320             


Leu Gly  Leu Pro Gly Ile Asp  Gly Ile Pro Gly Leu  Xaa Gly Asp 
    1325                 1330                 1335             


Pro Gly  Ala Gln Gly Pro Val  Gly Leu Gln Gly Ser  Lys Gly Leu 
    1340                 1345                 1350             


Pro Gly  Ile Pro Gly Lys Asp  Gly Pro Ser Gly Leu  Pro Gly Pro 
    1355                 1360                 1365             


Pro Gly  Ala Leu Gly Asp Pro  Gly Leu Pro Gly Leu  Gln Gly Pro 
    1370                 1375                 1380             


Pro Gly  Phe Glu Gly Ala Pro  Gly Gln Gln Gly Pro  Phe Gly Met 
    1385                 1390                 1395             


Pro Gly  Met Pro Gly Gln Ser  Met Arg Val Gly Tyr  Xaa Leu Val 
    1400                 1405                 1410             


Lys His  Ser Gln Ser Glu Gln  Val Pro Pro Cys Pro  Ile Gly Met 
    1415                 1420                 1425             


Ser Gln  Leu Trp Val Gly Tyr  Ser Leu Leu Phe Val  Glu Gly Gln 
    1430                 1435                 1440             


Glu Lys  Ala His Asn Gln Asp  Leu Gly Phe Ala Gly  Ser Cys Leu 
    1445                 1450                 1455             


Pro Arg  Phe Ser Xaa Met Pro  Phe Ile Tyr Cys Asn  Ile Asn Glu 
    1460                 1465                 1470             


Val Cys  His Tyr Ala Arg Arg  Asn Asp Lys Ser Tyr  Trp Leu Ser 
    1475                 1480                 1485             


Xaa Xaa  Ala Pro Ile Pro Met  Met Pro Val Ser Gln  Xaa Gln Ile 
    1490                 1495                 1500             


Pro Gln  Tyr Ile Ser Arg Cys  Ser Val Cys Glu Ala  Pro Ser Gln 
    1505                 1510                 1515             


Ala Ile  Ala Val His Ser Gln  Asp Ile Xaa Ile Pro  Gln Cys Pro 
    1520                 1525                 1530             


Leu Gly  Trp Arg Ser Leu Trp  Ile Gly Tyr Ser Phe  Leu Met His 
    1535                 1540                 1545             


Xaa Ala  Ala Gly Ala Glu Gly  Gly Gly Gln Ser Leu  Val Ser Pro 
    1550                 1555                 1560             


Gly Ser  Cys Leu Glu Asp Phe  Arg Ala Xaa Pro Phe  Ile Glu Cys 
    1565                 1570                 1575             


Ser Gly  Ala Arg Gly Xaa Cys  His Tyr Phe Ala Asn  Lys Tyr Ser 
    1580                 1585                 1590             


Phe Trp  Leu Xaa Xaa Val Glu  Glu Arg Gln Gln Phe  Gly Glu Leu 
    1595                 1600                 1605             


Pro Val  Ser Glu Xaa Leu Lys  Ala Gly Gln Leu His  Xaa Arg Val 
    1610                 1615                 1620             


Ser Arg  Cys Gln Val Cys Met  Lys Ser Leu 
    1625                 1630             


<210> 6672
<211> 1666
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1310)..(1310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1344)..(1344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1346)..(1346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1369)..(1369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1444)..(1444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1496)..(1496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1522)..(1523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1534)..(1534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1561)..(1561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1582)..(1582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1617)..(1617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1630)..(1631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1646)..(1646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1654)..(1654)
<223> Selenocysteine

<400> 6672
Met His Pro Gly Leu Trp Leu Leu Leu Val Xaa Leu Cys Leu Xaa Glu 
1               5                   10                  15      


Glu Leu Ala Ala Ala Gly Glu Lys Ser Tyr Gly Lys Pro Cys Gly Gly 
            20                  25                  30          


Gln Asp Cys Ser Gly Ser Cys Gln Cys Phe Pro Glu Lys Gly Ala Arg 
        35                  40                  45              


Gly Arg Pro Gly Pro Ile Gly Ile Gln Gly Pro Xaa Gly Pro Gln Gly 
    50                  55                  60                  


Phe Xaa Gly Ser Xaa Gly Leu Ser Gly Leu Lys Gly Glu Arg Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Leu Gly Pro Tyr Gly Pro Lys Gly Asp Lys Gly Pro Met 
                85                  90                  95      


Gly Val Pro Gly Phe Leu Gly Ile Asn Gly Ile Pro Gly His Pro Gly 
            100                 105                 110         


Gln Pro Gly Pro Arg Gly Pro Pro Gly Leu Asp Gly Cys Asn Gly Xaa 
        115                 120                 125             


Gln Gly Ala Val Gly Phe Pro Gly Pro Asp Gly Tyr Pro Gly Leu Leu 
    130                 135                 140                 


Gly Pro Pro Gly Leu Pro Gly Gln Lys Gly Ser Lys Gly Asp Pro Val 
145                 150                 155                 160 


Leu Ala Pro Gly Ser Phe Lys Gly Met Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Leu Asp Gly Ile Xaa Gly Pro Gln Gly Ala Pro Gly Phe Pro Gly 
            180                 185                 190         


Ala Val Gly Pro Ala Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Pro Leu Gly Pro Asp Gly Asn Met Gly Leu Gly Phe Gln Gly 
    210                 215                 220                 


Glu Lys Gly Val Lys Gly Asp Val Gly Leu Pro Gly Pro Ala Gly Pro 
225                 230                 235                 240 


Pro Pro Ser Xaa Gly Glu Leu Glu Phe Met Gly Phe Pro Lys Gly Lys 
                245                 250                 255     


Lys Gly Ser Lys Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Ile Ser 
            260                 265                 270         


Gly Pro Pro Gly Phe Pro Gly Leu Gly Xaa Xaa Gly Glu Lys Gly Glu 
        275                 280                 285             


Lys Gly Glu Lys Gly Ile Pro Gly Leu Pro Gly Pro Arg Gly Pro Met 
    290                 295                 300                 


Gly Ser Glu Gly Val Gln Gly Pro Pro Gly Gln Gln Gly Lys Lys Gly 
305                 310                 315                 320 


Xaa Leu Gly Phe Pro Gly Leu Asn Gly Phe Gln Gly Ile Glu Gly Gln 
                325                 330                 335     


Lys Gly Asp Ile Gly Leu Pro Gly Pro Asp Val Phe Ile Asp Ile Asp 
            340                 345                 350         


Gly Ala Val Ile Ser Gly Asn Pro Gly Asp Pro Gly Val Pro Gly Leu 
        355                 360                 365             


Pro Gly Leu Lys Gly Asp Glu Gly Ile Gln Gly Leu Arg Gly Pro Ser 
    370                 375                 380                 


Gly Val Pro Gly Leu Pro Ala Leu Ser Gly Val Pro Gly Ala Leu Gly 
385                 390                 395                 400 


Pro Gln Gly Phe Pro Gly Leu Lys Gly Asp Gln Gly Asn Pro Gly Arg 
                405                 410                 415     


Xaa Xaa Ile Gly Ala Ala Gly Leu Pro Gly Arg Asp Gly Leu Pro Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Pro Pro Ser Pro Glu Phe Glu Xaa Glu Xaa 
        435                 440                 445             


Leu His Asn Lys Glu Ser Gly Phe Pro Gly Leu Arg Gly Glu Gln Gly 
    450                 455                 460                 


Pro Lys Gly Asn Leu Gly Leu Lys Gly Ile Lys Gly Asp Ser Gly Phe 
465                 470                 475                 480 


Cys Ala Cys Asp Gly Gly Val Pro Asn Xaa Gly Pro Pro Gly Glu Pro 
                485                 490                 495     


Gly Pro Pro Gly Pro Trp Gly Leu Ile Gly Leu Pro Gly Leu Lys Gly 
            500                 505                 510         


Ala Arg Gly Asp Arg Gly Ser Gly Gly Ala Gln Gly Pro Ala Gly Ala 
        515                 520                 525             


Pro Gly Leu Val Gly Pro Leu Gly Pro Ser Gly Pro Lys Gly Lys Lys 
    530                 535                 540                 


Gly Glu Pro Ile Leu Ser Xaa Ile Gln Gly Met Pro Gly Asp Arg Gly 
545                 550                 555                 560 


Asp Ser Gly Ser Gln Gly Phe Arg Gly Val Ile Gly Glu Pro Gly Lys 
                565                 570                 575     


Asp Gly Val Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Asp Gly 
            580                 585                 590         


Gly Gln Gly Phe Pro Gly Glu Lys Gly Leu Pro Gly Leu Pro Gly Glu 
        595                 600                 605             


Lys Gly His Pro Gly Pro Pro Gly Leu Pro Gly Asn Gly Leu Pro Gly 
    610                 615                 620                 


Leu Pro Gly Pro Arg Gly Leu Pro Gly Asp Lys Gly Lys Asp Gly Leu 
625                 630                 635                 640 


Pro Gly Gln Gln Gly Leu Pro Gly Ser Lys Gly Ile Xaa Leu Pro Cys 
                645                 650                 655     


Ile Ile Pro Gly Ser Tyr Gly Pro Ser Gly Phe Pro Gly Xaa Pro Gly 
            660                 665                 670         


Phe Pro Gly Pro Lys Gly Ser Arg Gly Leu Pro Gly Xaa Pro Gly Gln 
        675                 680                 685             


Pro Gly Ser Ser Gly Ser Lys Gly Glu Pro Gly Ser Pro Gly Leu Val 
    690                 695                 700                 


His Leu Pro Glu Leu Pro Gly Phe Pro Gly Pro Arg Gly Glu Lys Gly 
705                 710                 715                 720 


Leu Pro Gly Phe Pro Gly Leu Pro Gly Lys Asp Gly Leu Pro Gly Met 
                725                 730                 735     


Ile Gly Ser Pro Gly Leu Pro Gly Ser Lys Gly Ala Xaa Gly Asp Ile 
            740                 745                 750         


Phe Gly Ala Glu Asn Gly Ala Pro Gly Glu Gln Gly Leu Gln Gly Leu 
        755                 760                 765             


Xaa Gly His Lys Gly Phe Leu Gly Asp Ser Gly Leu Pro Gly Leu Lys 
    770                 775                 780                 


Gly Val His Gly Lys Pro Gly Leu Leu Gly Pro Lys Gly Glu Arg Gly 
785                 790                 795                 800 


Ser Pro Gly Xaa Pro Gly Gln Val Gly Gln Pro Gly Xaa Pro Gly Ser 
                805                 810                 815     


Ser Gly Pro Tyr Gly Ile Lys Gly Lys Ser Gly Leu Pro Gly Ala Pro 
            820                 825                 830         


Gly Phe Pro Gly Ile Ser Gly His Pro Gly Lys Lys Gly Xaa Arg Gly 
        835                 840                 845             


Lys Lys Gly Pro Pro Gly Ser Ile Val Lys Lys Gly Leu Pro Gly Leu 
    850                 855                 860                 


Lys Gly Leu Pro Gly Asn Pro Gly Leu Val Gly Leu Lys Gly Ser Pro 
865                 870                 875                 880 


Gly Ser Pro Gly Val Ala Gly Leu Pro Ala Leu Ser Gly Pro Lys Gly 
                885                 890                 895     


Glu Lys Gly Ser Val Gly Phe Val Gly Phe Pro Gly Ile Pro Gly Leu 
            900                 905                 910         


Pro Gly Ile Pro Gly Xaa Arg Gly Leu Lys Gly Ile Pro Gly Ser Xaa 
        915                 920                 925             


Gly Lys Met Gly Pro Ser Gly Arg Ala Gly Xaa Pro Gly Glu Lys Gly 
    930                 935                 940                 


Asp Arg Gly Asn Pro Gly Pro Val Gly Ile Pro Ser Pro Arg Arg Pro 
945                 950                 955                 960 


Met Ser Asn Leu Trp Leu Lys Gly Asp Lys Gly Ser Gln Gly Ser Ala 
                965                 970                 975     


Gly Ser Asn Gly Phe Pro Gly Pro Arg Gly Asp Lys Gly Glu Ala Gly 
            980                 985                 990         


Arg Pro Gly Pro Pro Gly Leu Pro  Gly Ala Pro Gly Leu  Pro Gly Ile 
        995                 1000                 1005             


Ile Lys  Gly Val Ser Gly Lys  Pro Gly Pro Pro Gly  Phe Met Gly 
    1010                 1015                 1020             


Ile Arg  Gly Leu Pro Gly Leu  Lys Gly Ser Ser Gly  Ile Xaa Gly 
    1025                 1030                 1035             


Phe Pro  Gly Met Pro Gly Glu  Ser Gly Ser Gln Gly  Ile Arg Gly 
    1040                 1045                 1050             


Ser Pro  Gly Leu Pro Gly Ala  Ser Gly Leu Pro Gly  Leu Lys Gly 
    1055                 1060                 1065             


Asp Asn  Gly Gln Xaa Val Glu  Ile Ser Gly Ser Pro  Gly Pro Lys 
    1070                 1075                 1080             


Gly Gln  Pro Gly Glu Ser Gly  Phe Lys Gly Xaa Lys  Gly Arg Asp 
    1085                 1090                 1095             


Gly Leu  Ile Gly Asn Ile Gly  Phe Pro Gly Asn Lys  Gly Glu Asp 
    1100                 1105                 1110             


Gly Lys  Val Gly Val Ser Gly  Asp Val Gly Leu Pro  Gly Ala Pro 
    1115                 1120                 1125             


Gly Phe  Pro Gly Val Ala Gly  Met Arg Gly Glu Pro  Gly Leu Pro 
    1130                 1135                 1140             


Gly Ser  Ser Gly His Gln Gly  Ala Ile Gly Pro Leu  Gly Ser Pro 
    1145                 1150                 1155             


Gly Leu  Ile Gly Pro Lys Gly  Pro Ser Ile Xaa Gly  Val Pro Gly 
    1160                 1165                 1170             


Pro Ala  Gly Leu Pro Gly Pro  Lys Gly Glu Lys Gly  Tyr Pro Gly 
    1175                 1180                 1185             


Ile Gly  Ile Gly Ala Pro Gly  Lys Pro Gly Leu Arg  Gly Gln Lys 
    1190                 1195                 1200             


Gly Asp  Arg Gly Phe Pro Gly  Leu Gln Gly Pro Ala  Gly Leu Pro 
    1205                 1210                 1215             


Gly Ala  Pro Gly Ile Ser Leu  Pro Ser Leu Ile Ala  Gly Gln Pro 
    1220                 1225                 1230             


Gly Asp  Pro Gly Arg Pro Gly  Leu Asp Gly Glu Arg  Gly Arg Pro 
    1235                 1240                 1245             


Gly Pro  Ala Gly Pro Pro Gly  Pro Pro Gly Pro Ser  Ser Asn Gln 
    1250                 1255                 1260             


Gly Asp  Xaa Gly Asp Pro Gly  Phe Pro Gly Ile Pro  Gly Pro Lys 
    1265                 1270                 1275             


Gly Pro  Lys Gly Asp Gln Gly  Ile Pro Gly Phe Ser  Gly Leu Pro 
    1280                 1285                 1290             


Gly Glu  Leu Gly Leu Lys Gly  Met Arg Gly Glu Pro  Gly Phe Met 
    1295                 1300                 1305             


Gly Xaa  Pro Gly Lys Val Gly  Pro Pro Gly Asp Pro  Gly Phe Pro 
    1310                 1315                 1320             


Gly Met  Lys Gly Lys Ala Gly  Pro Arg Gly Ser Ser  Gly Leu Gln 
    1325                 1330                 1335             


Gly Asp  Pro Gly Gln Xaa Pro  Xaa Ala Glu Ala Val  Gln Val Pro 
    1340                 1345                 1350             


Pro Gly  Pro Leu Gly Leu Pro  Gly Ile Asp Gly Ile  Pro Gly Leu 
    1355                 1360                 1365             


Xaa Gly  Asp Pro Gly Ala Gln  Gly Pro Val Gly Leu  Gln Gly Ser 
    1370                 1375                 1380             


Lys Gly  Leu Pro Gly Ile Pro  Gly Lys Asp Gly Pro  Ser Gly Leu 
    1385                 1390                 1395             


Pro Gly  Pro Pro Gly Ala Leu  Gly Asp Pro Gly Leu  Pro Gly Leu 
    1400                 1405                 1410             


Gln Gly  Pro Pro Gly Phe Glu  Gly Ala Pro Gly Gln  Gln Gly Pro 
    1415                 1420                 1425             


Phe Gly  Met Pro Gly Met Pro  Gly Gln Ser Met Arg  Val Gly Tyr 
    1430                 1435                 1440             


Xaa Leu  Val Lys His Ser Gln  Ser Glu Gln Val Pro  Pro Cys Pro 
    1445                 1450                 1455             


Ile Gly  Met Ser Gln Leu Trp  Val Gly Tyr Ser Leu  Leu Phe Val 
    1460                 1465                 1470             


Glu Gly  Gln Glu Lys Ala His  Asn Gln Asp Leu Gly  Phe Ala Gly 
    1475                 1480                 1485             


Ser Cys  Leu Pro Arg Phe Ser  Xaa Met Pro Phe Ile  Tyr Cys Asn 
    1490                 1495                 1500             


Ile Asn  Glu Val Cys His Tyr  Ala Arg Arg Asn Asp  Lys Ser Tyr 
    1505                 1510                 1515             


Trp Leu  Ser Xaa Xaa Ala Pro  Ile Pro Met Met Pro  Val Ser Gln 
    1520                 1525                 1530             


Xaa Gln  Ile Pro Gln Tyr Ile  Ser Arg Cys Ser Val  Cys Glu Ala 
    1535                 1540                 1545             


Pro Ser  Gln Ala Ile Ala Val  His Ser Gln Asp Ile  Xaa Ile Pro 
    1550                 1555                 1560             


Gln Cys  Pro Leu Gly Trp Arg  Ser Leu Trp Ile Gly  Tyr Ser Phe 
    1565                 1570                 1575             


Leu Met  His Xaa Ala Ala Gly  Ala Glu Gly Gly Gly  Gln Ser Leu 
    1580                 1585                 1590             


Val Ser  Pro Gly Ser Cys Leu  Glu Asp Phe Arg Ala  Xaa Pro Phe 
    1595                 1600                 1605             


Ile Glu  Cys Ser Gly Ala Arg  Gly Xaa Cys His Tyr  Phe Ala Asn 
    1610                 1615                 1620             


Lys Tyr  Ser Phe Trp Leu Xaa  Xaa Val Glu Glu Arg  Gln Gln Phe 
    1625                 1630                 1635             


Gly Glu  Leu Pro Val Ser Glu  Xaa Leu Lys Ala Gly  Gln Leu His 
    1640                 1645                 1650             


Xaa Arg  Val Ser Arg Cys Gln  Val Cys Met Lys Ser  Leu 
    1655                 1660                 1665     


<210> 6673
<211> 1678
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1184)..(1184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1187)..(1187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1193)..(1193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1322)..(1322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1356)..(1356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1456)..(1456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1508)..(1508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1534)..(1535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1546)..(1546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1573)..(1573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1594)..(1594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1618)..(1618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1629)..(1629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1642)..(1643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1658)..(1658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1666)..(1666)
<223> Selenocysteine

<400> 6673
Met His Pro Gly Leu Trp Leu Leu Leu Val Xaa Leu Cys Leu Xaa Glu 
1               5                   10                  15      


Glu Leu Ala Ala Ala Gly Glu Lys Ser Tyr Gly Lys Pro Cys Gly Gly 
            20                  25                  30          


Gln Asp Cys Ser Gly Ser Cys Gln Cys Phe Pro Glu Lys Gly Ala Arg 
        35                  40                  45              


Gly Arg Pro Gly Pro Ile Gly Ile Gln Gly Pro Xaa Gly Pro Gln Gly 
    50                  55                  60                  


Phe Xaa Gly Ser Xaa Gly Leu Ser Gly Leu Lys Gly Glu Arg Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Leu Gly Pro Tyr Gly Pro Lys Gly Asp Lys Gly Pro Met 
                85                  90                  95      


Gly Val Pro Gly Phe Leu Gly Ile Asn Gly Ile Pro Gly His Pro Gly 
            100                 105                 110         


Gln Pro Gly Pro Arg Gly Pro Pro Gly Leu Asp Gly Cys Asn Gly Xaa 
        115                 120                 125             


Gln Gly Ala Val Gly Phe Pro Gly Pro Asp Gly Tyr Pro Gly Leu Leu 
    130                 135                 140                 


Gly Pro Pro Gly Leu Pro Gly Gln Lys Gly Ser Lys Gly Asp Pro Val 
145                 150                 155                 160 


Leu Ala Pro Gly Ser Phe Lys Gly Met Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Leu Asp Gly Ile Xaa Gly Pro Gln Gly Ala Pro Gly Phe Pro Gly 
            180                 185                 190         


Ala Val Gly Pro Ala Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Pro Leu Gly Pro Asp Gly Asn Met Gly Leu Gly Phe Gln Gly 
    210                 215                 220                 


Glu Lys Gly Val Lys Gly Asp Val Gly Leu Pro Gly Pro Ala Gly Pro 
225                 230                 235                 240 


Pro Pro Ser Xaa Gly Glu Leu Glu Phe Met Gly Phe Pro Lys Gly Lys 
                245                 250                 255     


Lys Gly Ser Lys Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Ile Ser 
            260                 265                 270         


Gly Pro Pro Gly Phe Pro Gly Leu Gly Xaa Xaa Gly Glu Lys Gly Glu 
        275                 280                 285             


Lys Gly Glu Lys Gly Ile Pro Gly Leu Pro Gly Pro Arg Gly Pro Met 
    290                 295                 300                 


Gly Ser Glu Gly Val Gln Gly Pro Pro Gly Gln Gln Gly Lys Lys Gly 
305                 310                 315                 320 


Xaa Leu Gly Phe Pro Gly Leu Asn Gly Phe Gln Gly Ile Glu Gly Gln 
                325                 330                 335     


Lys Gly Asp Ile Gly Leu Pro Gly Pro Asp Val Phe Ile Asp Ile Asp 
            340                 345                 350         


Gly Ala Val Ile Ser Gly Asn Pro Gly Asp Pro Gly Val Pro Gly Leu 
        355                 360                 365             


Pro Gly Leu Lys Gly Asp Glu Gly Ile Gln Gly Leu Arg Gly Pro Ser 
    370                 375                 380                 


Gly Val Pro Gly Leu Pro Ala Leu Ser Gly Val Pro Gly Ala Leu Gly 
385                 390                 395                 400 


Pro Gln Gly Phe Pro Gly Leu Lys Gly Asp Gln Gly Asn Pro Gly Arg 
                405                 410                 415     


Xaa Xaa Ile Gly Ala Ala Gly Leu Pro Gly Arg Asp Gly Leu Pro Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Pro Pro Ser Pro Glu Phe Glu Xaa Glu Xaa 
        435                 440                 445             


Leu His Asn Lys Glu Ser Gly Phe Pro Gly Leu Arg Gly Glu Gln Gly 
    450                 455                 460                 


Pro Lys Gly Asn Leu Gly Leu Lys Gly Ile Lys Gly Asp Ser Gly Phe 
465                 470                 475                 480 


Cys Ala Cys Asp Gly Gly Val Pro Asn Xaa Gly Pro Pro Gly Glu Pro 
                485                 490                 495     


Gly Pro Pro Gly Pro Trp Gly Leu Ile Gly Leu Pro Gly Leu Lys Gly 
            500                 505                 510         


Ala Arg Gly Asp Arg Gly Ser Gly Gly Ala Gln Gly Pro Ala Gly Ala 
        515                 520                 525             


Pro Gly Leu Val Gly Pro Leu Gly Pro Ser Gly Pro Lys Gly Lys Lys 
    530                 535                 540                 


Gly Glu Pro Ile Leu Ser Xaa Ile Gln Gly Met Pro Gly Asp Arg Gly 
545                 550                 555                 560 


Asp Ser Gly Ser Gln Gly Phe Arg Gly Val Ile Gly Glu Pro Gly Lys 
                565                 570                 575     


Asp Gly Val Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Asp Gly 
            580                 585                 590         


Gly Gln Gly Phe Pro Gly Glu Lys Gly Leu Pro Gly Leu Pro Gly Glu 
        595                 600                 605             


Lys Gly His Pro Gly Pro Pro Gly Leu Pro Gly Asn Gly Leu Pro Gly 
    610                 615                 620                 


Leu Pro Gly Pro Arg Gly Leu Pro Gly Asp Lys Gly Lys Asp Gly Leu 
625                 630                 635                 640 


Pro Gly Gln Gln Gly Leu Pro Gly Ser Lys Gly Ile Xaa Leu Pro Cys 
                645                 650                 655     


Ile Ile Pro Gly Ser Tyr Gly Pro Ser Gly Phe Pro Gly Xaa Pro Gly 
            660                 665                 670         


Phe Pro Gly Pro Lys Gly Ser Arg Gly Leu Pro Gly Xaa Pro Gly Gln 
        675                 680                 685             


Pro Gly Ser Ser Gly Ser Lys Gly Glu Pro Gly Ser Pro Gly Leu Val 
    690                 695                 700                 


His Leu Pro Glu Leu Pro Gly Phe Pro Gly Pro Arg Gly Glu Lys Gly 
705                 710                 715                 720 


Leu Pro Gly Phe Pro Gly Leu Pro Gly Lys Asp Gly Leu Pro Gly Met 
                725                 730                 735     


Ile Gly Ser Pro Gly Leu Pro Gly Ser Lys Gly Ala Xaa Gly Asp Ile 
            740                 745                 750         


Phe Gly Ala Glu Asn Gly Ala Pro Gly Glu Gln Gly Leu Gln Gly Leu 
        755                 760                 765             


Xaa Gly His Lys Gly Phe Leu Gly Asp Ser Gly Leu Pro Gly Leu Lys 
    770                 775                 780                 


Gly Val His Gly Lys Pro Gly Leu Leu Gly Pro Lys Gly Glu Arg Gly 
785                 790                 795                 800 


Ser Pro Gly Xaa Pro Gly Gln Val Gly Gln Pro Gly Xaa Pro Gly Ser 
                805                 810                 815     


Ser Gly Pro Tyr Gly Ile Lys Gly Lys Ser Gly Leu Pro Gly Ala Pro 
            820                 825                 830         


Gly Phe Pro Gly Ile Ser Gly His Pro Gly Lys Lys Gly Xaa Arg Gly 
        835                 840                 845             


Lys Lys Gly Pro Pro Gly Ser Ile Val Lys Lys Gly Leu Pro Gly Leu 
    850                 855                 860                 


Lys Gly Leu Pro Gly Asn Pro Gly Leu Val Gly Leu Lys Gly Ser Pro 
865                 870                 875                 880 


Gly Ser Pro Gly Val Ala Gly Leu Pro Ala Leu Ser Gly Pro Lys Gly 
                885                 890                 895     


Glu Lys Gly Ser Val Gly Phe Val Gly Phe Pro Gly Ile Pro Gly Leu 
            900                 905                 910         


Pro Gly Ile Pro Gly Xaa Arg Gly Leu Lys Gly Ile Pro Gly Ser Xaa 
        915                 920                 925             


Gly Lys Met Gly Pro Ser Gly Arg Ala Gly Xaa Pro Gly Glu Lys Gly 
    930                 935                 940                 


Asp Arg Gly Asn Pro Gly Pro Val Gly Ile Pro Ser Pro Arg Arg Pro 
945                 950                 955                 960 


Met Ser Asn Leu Trp Leu Lys Gly Asp Lys Gly Ser Gln Gly Ser Ala 
                965                 970                 975     


Gly Ser Asn Gly Phe Pro Gly Pro Arg Gly Asp Lys Gly Glu Ala Gly 
            980                 985                 990         


Arg Pro Gly Pro Pro Gly Leu Pro  Gly Ala Pro Gly Leu  Pro Gly Ile 
        995                 1000                 1005             


Ile Lys  Gly Val Ser Gly Lys  Pro Gly Pro Pro Gly  Phe Met Gly 
    1010                 1015                 1020             


Ile Arg  Gly Leu Pro Gly Leu  Lys Gly Ser Ser Gly  Ile Xaa Gly 
    1025                 1030                 1035             


Phe Pro  Gly Met Pro Gly Glu  Ser Gly Ser Gln Gly  Ile Arg Gly 
    1040                 1045                 1050             


Ser Pro  Gly Leu Pro Gly Ala  Ser Gly Leu Pro Gly  Leu Lys Gly 
    1055                 1060                 1065             


Asp Asn  Gly Gln Xaa Val Glu  Ile Ser Gly Ser Pro  Gly Pro Lys 
    1070                 1075                 1080             


Gly Gln  Pro Gly Glu Ser Gly  Phe Lys Gly Xaa Lys  Gly Arg Asp 
    1085                 1090                 1095             


Gly Leu  Ile Gly Asn Ile Gly  Phe Pro Gly Asn Lys  Gly Glu Asp 
    1100                 1105                 1110             


Gly Lys  Val Gly Val Ser Gly  Asp Val Gly Leu Pro  Gly Ala Pro 
    1115                 1120                 1125             


Gly Phe  Pro Gly Val Ala Gly  Met Arg Gly Glu Pro  Gly Leu Pro 
    1130                 1135                 1140             


Gly Ser  Ser Gly His Gln Gly  Ala Ile Gly Pro Leu  Gly Ser Pro 
    1145                 1150                 1155             


Gly Leu  Ile Gly Pro Lys Gly  Phe Pro Gly Phe Pro  Gly Leu His 
    1160                 1165                 1170             


Gly Leu  Asn Gly Leu Pro Gly  Xaa Lys Gly Xaa His  Gly Xaa Pro 
    1175                 1180                 1185             


Gly Pro  Ser Ile Xaa Gly Val  Pro Gly Pro Ala Gly  Leu Pro Gly 
    1190                 1195                 1200             


Pro Lys  Gly Glu Lys Gly Tyr  Pro Gly Ile Gly Ile  Gly Ala Pro 
    1205                 1210                 1215             


Gly Lys  Pro Gly Leu Arg Gly  Gln Lys Gly Asp Arg  Gly Phe Pro 
    1220                 1225                 1230             


Gly Leu  Gln Gly Pro Ala Gly  Leu Pro Gly Ala Pro  Gly Ile Ser 
    1235                 1240                 1245             


Leu Pro  Ser Leu Ile Ala Gly  Gln Pro Gly Asp Pro  Gly Arg Pro 
    1250                 1255                 1260             


Gly Leu  Asp Gly Glu Arg Gly  Arg Pro Gly Pro Ala  Gly Pro Pro 
    1265                 1270                 1275             


Gly Pro  Pro Gly Pro Ser Ser  Asn Gln Gly Asp Xaa  Gly Asp Pro 
    1280                 1285                 1290             


Gly Phe  Pro Gly Ile Pro Gly  Phe Ser Gly Leu Pro  Gly Glu Leu 
    1295                 1300                 1305             


Gly Leu  Lys Gly Met Arg Gly  Glu Pro Gly Phe Met  Gly Xaa Pro 
    1310                 1315                 1320             


Gly Lys  Val Gly Pro Pro Gly  Asp Pro Gly Phe Pro  Gly Met Lys 
    1325                 1330                 1335             


Gly Lys  Ala Gly Pro Arg Gly  Ser Ser Gly Leu Gln  Gly Asp Pro 
    1340                 1345                 1350             


Gly Gln  Xaa Pro Xaa Ala Glu  Ala Val Gln Val Pro  Pro Gly Pro 
    1355                 1360                 1365             


Leu Gly  Leu Pro Gly Ile Asp  Gly Ile Pro Gly Leu  Xaa Gly Asp 
    1370                 1375                 1380             


Pro Gly  Ala Gln Gly Pro Val  Gly Leu Gln Gly Ser  Lys Gly Leu 
    1385                 1390                 1395             


Pro Gly  Ile Pro Gly Lys Asp  Gly Pro Ser Gly Leu  Pro Gly Pro 
    1400                 1405                 1410             


Pro Gly  Ala Leu Gly Asp Pro  Gly Leu Pro Gly Leu  Gln Gly Pro 
    1415                 1420                 1425             


Pro Gly  Phe Glu Gly Ala Pro  Gly Gln Gln Gly Pro  Phe Gly Met 
    1430                 1435                 1440             


Pro Gly  Met Pro Gly Gln Ser  Met Arg Val Gly Tyr  Xaa Leu Val 
    1445                 1450                 1455             


Lys His  Ser Gln Ser Glu Gln  Val Pro Pro Cys Pro  Ile Gly Met 
    1460                 1465                 1470             


Ser Gln  Leu Trp Val Gly Tyr  Ser Leu Leu Phe Val  Glu Gly Gln 
    1475                 1480                 1485             


Glu Lys  Ala His Asn Gln Asp  Leu Gly Phe Ala Gly  Ser Cys Leu 
    1490                 1495                 1500             


Pro Arg  Phe Ser Xaa Met Pro  Phe Ile Tyr Cys Asn  Ile Asn Glu 
    1505                 1510                 1515             


Val Cys  His Tyr Ala Arg Arg  Asn Asp Lys Ser Tyr  Trp Leu Ser 
    1520                 1525                 1530             


Xaa Xaa  Ala Pro Ile Pro Met  Met Pro Val Ser Gln  Xaa Gln Ile 
    1535                 1540                 1545             


Pro Gln  Tyr Ile Ser Arg Cys  Ser Val Cys Glu Ala  Pro Ser Gln 
    1550                 1555                 1560             


Ala Ile  Ala Val His Ser Gln  Asp Ile Xaa Ile Pro  Gln Cys Pro 
    1565                 1570                 1575             


Leu Gly  Trp Arg Ser Leu Trp  Ile Gly Tyr Ser Phe  Leu Met His 
    1580                 1585                 1590             


Xaa Ala  Ala Gly Ala Glu Gly  Gly Gly Gln Ser Leu  Val Ser Pro 
    1595                 1600                 1605             


Gly Ser  Cys Leu Glu Asp Phe  Arg Ala Xaa Pro Phe  Ile Glu Cys 
    1610                 1615                 1620             


Ser Gly  Ala Arg Gly Xaa Cys  His Tyr Phe Ala Asn  Lys Tyr Ser 
    1625                 1630                 1635             


Phe Trp  Leu Xaa Xaa Val Glu  Glu Arg Gln Gln Phe  Gly Glu Leu 
    1640                 1645                 1650             


Pro Val  Ser Glu Xaa Leu Lys  Ala Gly Gln Leu His  Xaa Arg Val 
    1655                 1660                 1665             


Ser Arg  Cys Gln Val Cys Met  Lys Ser Leu 
    1670                 1675             


<210> 6674
<211> 1690
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1181)..(1181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1184)..(1184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1187)..(1187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1193)..(1193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1334)..(1334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1368)..(1368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1370)..(1370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1393)..(1393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1520)..(1520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1546)..(1547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1558)..(1558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1585)..(1585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1606)..(1606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1630)..(1630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1641)..(1641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1654)..(1655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1670)..(1670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1678)..(1678)
<223> Selenocysteine

<400> 6674
Met His Pro Gly Leu Trp Leu Leu Leu Val Xaa Leu Cys Leu Xaa Glu 
1               5                   10                  15      


Glu Leu Ala Ala Ala Gly Glu Lys Ser Tyr Gly Lys Pro Cys Gly Gly 
            20                  25                  30          


Gln Asp Cys Ser Gly Ser Cys Gln Cys Phe Pro Glu Lys Gly Ala Arg 
        35                  40                  45              


Gly Arg Pro Gly Pro Ile Gly Ile Gln Gly Pro Xaa Gly Pro Gln Gly 
    50                  55                  60                  


Phe Xaa Gly Ser Xaa Gly Leu Ser Gly Leu Lys Gly Glu Arg Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Leu Gly Pro Tyr Gly Pro Lys Gly Asp Lys Gly Pro Met 
                85                  90                  95      


Gly Val Pro Gly Phe Leu Gly Ile Asn Gly Ile Pro Gly His Pro Gly 
            100                 105                 110         


Gln Pro Gly Pro Arg Gly Pro Pro Gly Leu Asp Gly Cys Asn Gly Xaa 
        115                 120                 125             


Gln Gly Ala Val Gly Phe Pro Gly Pro Asp Gly Tyr Pro Gly Leu Leu 
    130                 135                 140                 


Gly Pro Pro Gly Leu Pro Gly Gln Lys Gly Ser Lys Gly Asp Pro Val 
145                 150                 155                 160 


Leu Ala Pro Gly Ser Phe Lys Gly Met Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Leu Asp Gly Ile Xaa Gly Pro Gln Gly Ala Pro Gly Phe Pro Gly 
            180                 185                 190         


Ala Val Gly Pro Ala Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Pro Leu Gly Pro Asp Gly Asn Met Gly Leu Gly Phe Gln Gly 
    210                 215                 220                 


Glu Lys Gly Val Lys Gly Asp Val Gly Leu Pro Gly Pro Ala Gly Pro 
225                 230                 235                 240 


Pro Pro Ser Xaa Gly Glu Leu Glu Phe Met Gly Phe Pro Lys Gly Lys 
                245                 250                 255     


Lys Gly Ser Lys Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Ile Ser 
            260                 265                 270         


Gly Pro Pro Gly Phe Pro Gly Leu Gly Xaa Xaa Gly Glu Lys Gly Glu 
        275                 280                 285             


Lys Gly Glu Lys Gly Ile Pro Gly Leu Pro Gly Pro Arg Gly Pro Met 
    290                 295                 300                 


Gly Ser Glu Gly Val Gln Gly Pro Pro Gly Gln Gln Gly Lys Lys Gly 
305                 310                 315                 320 


Xaa Leu Gly Phe Pro Gly Leu Asn Gly Phe Gln Gly Ile Glu Gly Gln 
                325                 330                 335     


Lys Gly Asp Ile Gly Leu Pro Gly Pro Asp Val Phe Ile Asp Ile Asp 
            340                 345                 350         


Gly Ala Val Ile Ser Gly Asn Pro Gly Asp Pro Gly Val Pro Gly Leu 
        355                 360                 365             


Pro Gly Leu Lys Gly Asp Glu Gly Ile Gln Gly Leu Arg Gly Pro Ser 
    370                 375                 380                 


Gly Val Pro Gly Leu Pro Ala Leu Ser Gly Val Pro Gly Ala Leu Gly 
385                 390                 395                 400 


Pro Gln Gly Phe Pro Gly Leu Lys Gly Asp Gln Gly Asn Pro Gly Arg 
                405                 410                 415     


Xaa Xaa Ile Gly Ala Ala Gly Leu Pro Gly Arg Asp Gly Leu Pro Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Pro Pro Ser Pro Glu Phe Glu Xaa Glu Xaa 
        435                 440                 445             


Leu His Asn Lys Glu Ser Gly Phe Pro Gly Leu Arg Gly Glu Gln Gly 
    450                 455                 460                 


Pro Lys Gly Asn Leu Gly Leu Lys Gly Ile Lys Gly Asp Ser Gly Phe 
465                 470                 475                 480 


Cys Ala Cys Asp Gly Gly Val Pro Asn Xaa Gly Pro Pro Gly Glu Pro 
                485                 490                 495     


Gly Pro Pro Gly Pro Trp Gly Leu Ile Gly Leu Pro Gly Leu Lys Gly 
            500                 505                 510         


Ala Arg Gly Asp Arg Gly Ser Gly Gly Ala Gln Gly Pro Ala Gly Ala 
        515                 520                 525             


Pro Gly Leu Val Gly Pro Leu Gly Pro Ser Gly Pro Lys Gly Lys Lys 
    530                 535                 540                 


Gly Glu Pro Ile Leu Ser Xaa Ile Gln Gly Met Pro Gly Asp Arg Gly 
545                 550                 555                 560 


Asp Ser Gly Ser Gln Gly Phe Arg Gly Val Ile Gly Glu Pro Gly Lys 
                565                 570                 575     


Asp Gly Val Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Asp Gly 
            580                 585                 590         


Gly Gln Gly Phe Pro Gly Glu Lys Gly Leu Pro Gly Leu Pro Gly Glu 
        595                 600                 605             


Lys Gly His Pro Gly Pro Pro Gly Leu Pro Gly Asn Gly Leu Pro Gly 
    610                 615                 620                 


Leu Pro Gly Pro Arg Gly Leu Pro Gly Asp Lys Gly Lys Asp Gly Leu 
625                 630                 635                 640 


Pro Gly Gln Gln Gly Leu Pro Gly Ser Lys Gly Ile Xaa Leu Pro Cys 
                645                 650                 655     


Ile Ile Pro Gly Ser Tyr Gly Pro Ser Gly Phe Pro Gly Xaa Pro Gly 
            660                 665                 670         


Phe Pro Gly Pro Lys Gly Ser Arg Gly Leu Pro Gly Xaa Pro Gly Gln 
        675                 680                 685             


Pro Gly Ser Ser Gly Ser Lys Gly Glu Pro Gly Ser Pro Gly Leu Val 
    690                 695                 700                 


His Leu Pro Glu Leu Pro Gly Phe Pro Gly Pro Arg Gly Glu Lys Gly 
705                 710                 715                 720 


Leu Pro Gly Phe Pro Gly Leu Pro Gly Lys Asp Gly Leu Pro Gly Met 
                725                 730                 735     


Ile Gly Ser Pro Gly Leu Pro Gly Ser Lys Gly Ala Xaa Gly Asp Ile 
            740                 745                 750         


Phe Gly Ala Glu Asn Gly Ala Pro Gly Glu Gln Gly Leu Gln Gly Leu 
        755                 760                 765             


Xaa Gly His Lys Gly Phe Leu Gly Asp Ser Gly Leu Pro Gly Leu Lys 
    770                 775                 780                 


Gly Val His Gly Lys Pro Gly Leu Leu Gly Pro Lys Gly Glu Arg Gly 
785                 790                 795                 800 


Ser Pro Gly Xaa Pro Gly Gln Val Gly Gln Pro Gly Xaa Pro Gly Ser 
                805                 810                 815     


Ser Gly Pro Tyr Gly Ile Lys Gly Lys Ser Gly Leu Pro Gly Ala Pro 
            820                 825                 830         


Gly Phe Pro Gly Ile Ser Gly His Pro Gly Lys Lys Gly Xaa Arg Gly 
        835                 840                 845             


Lys Lys Gly Pro Pro Gly Ser Ile Val Lys Lys Gly Leu Pro Gly Leu 
    850                 855                 860                 


Lys Gly Leu Pro Gly Asn Pro Gly Leu Val Gly Leu Lys Gly Ser Pro 
865                 870                 875                 880 


Gly Ser Pro Gly Val Ala Gly Leu Pro Ala Leu Ser Gly Pro Lys Gly 
                885                 890                 895     


Glu Lys Gly Ser Val Gly Phe Val Gly Phe Pro Gly Ile Pro Gly Leu 
            900                 905                 910         


Pro Gly Ile Pro Gly Xaa Arg Gly Leu Lys Gly Ile Pro Gly Ser Xaa 
        915                 920                 925             


Gly Lys Met Gly Pro Ser Gly Arg Ala Gly Xaa Pro Gly Glu Lys Gly 
    930                 935                 940                 


Asp Arg Gly Asn Pro Gly Pro Val Gly Ile Pro Ser Pro Arg Arg Pro 
945                 950                 955                 960 


Met Ser Asn Leu Trp Leu Lys Gly Asp Lys Gly Ser Gln Gly Ser Ala 
                965                 970                 975     


Gly Ser Asn Gly Phe Pro Gly Pro Arg Gly Asp Lys Gly Glu Ala Gly 
            980                 985                 990         


Arg Pro Gly Pro Pro Gly Leu Pro  Gly Ala Pro Gly Leu  Pro Gly Ile 
        995                 1000                 1005             


Ile Lys  Gly Val Ser Gly Lys  Pro Gly Pro Pro Gly  Phe Met Gly 
    1010                 1015                 1020             


Ile Arg  Gly Leu Pro Gly Leu  Lys Gly Ser Ser Gly  Ile Xaa Gly 
    1025                 1030                 1035             


Phe Pro  Gly Met Pro Gly Glu  Ser Gly Ser Gln Gly  Ile Arg Gly 
    1040                 1045                 1050             


Ser Pro  Gly Leu Pro Gly Ala  Ser Gly Leu Pro Gly  Leu Lys Gly 
    1055                 1060                 1065             


Asp Asn  Gly Gln Xaa Val Glu  Ile Ser Gly Ser Pro  Gly Pro Lys 
    1070                 1075                 1080             


Gly Gln  Pro Gly Glu Ser Gly  Phe Lys Gly Xaa Lys  Gly Arg Asp 
    1085                 1090                 1095             


Gly Leu  Ile Gly Asn Ile Gly  Phe Pro Gly Asn Lys  Gly Glu Asp 
    1100                 1105                 1110             


Gly Lys  Val Gly Val Ser Gly  Asp Val Gly Leu Pro  Gly Ala Pro 
    1115                 1120                 1125             


Gly Phe  Pro Gly Val Ala Gly  Met Arg Gly Glu Pro  Gly Leu Pro 
    1130                 1135                 1140             


Gly Ser  Ser Gly His Gln Gly  Ala Ile Gly Pro Leu  Gly Ser Pro 
    1145                 1150                 1155             


Gly Leu  Ile Gly Pro Lys Gly  Phe Pro Gly Phe Pro  Gly Leu His 
    1160                 1165                 1170             


Gly Leu  Asn Gly Leu Pro Gly  Xaa Lys Gly Xaa His  Gly Xaa Pro 
    1175                 1180                 1185             


Gly Pro  Ser Ile Xaa Gly Val  Pro Gly Pro Ala Gly  Leu Pro Gly 
    1190                 1195                 1200             


Pro Lys  Gly Glu Lys Gly Tyr  Pro Gly Ile Gly Ile  Gly Ala Pro 
    1205                 1210                 1215             


Gly Lys  Pro Gly Leu Arg Gly  Gln Lys Gly Asp Arg  Gly Phe Pro 
    1220                 1225                 1230             


Gly Leu  Gln Gly Pro Ala Gly  Leu Pro Gly Ala Pro  Gly Ile Ser 
    1235                 1240                 1245             


Leu Pro  Ser Leu Ile Ala Gly  Gln Pro Gly Asp Pro  Gly Arg Pro 
    1250                 1255                 1260             


Gly Leu  Asp Gly Glu Arg Gly  Arg Pro Gly Pro Ala  Gly Pro Pro 
    1265                 1270                 1275             


Gly Pro  Pro Gly Pro Ser Ser  Asn Gln Gly Asp Xaa  Gly Asp Pro 
    1280                 1285                 1290             


Gly Phe  Pro Gly Ile Pro Gly  Pro Lys Gly Pro Lys  Gly Asp Gln 
    1295                 1300                 1305             


Gly Ile  Pro Gly Phe Ser Gly  Leu Pro Gly Glu Leu  Gly Leu Lys 
    1310                 1315                 1320             


Gly Met  Arg Gly Glu Pro Gly  Phe Met Gly Xaa Pro  Gly Lys Val 
    1325                 1330                 1335             


Gly Pro  Pro Gly Asp Pro Gly  Phe Pro Gly Met Lys  Gly Lys Ala 
    1340                 1345                 1350             


Gly Pro  Arg Gly Ser Ser Gly  Leu Gln Gly Asp Pro  Gly Gln Xaa 
    1355                 1360                 1365             


Pro Xaa  Ala Glu Ala Val Gln  Val Pro Pro Gly Pro  Leu Gly Leu 
    1370                 1375                 1380             


Pro Gly  Ile Asp Gly Ile Pro  Gly Leu Xaa Gly Asp  Pro Gly Ala 
    1385                 1390                 1395             


Gln Gly  Pro Val Gly Leu Gln  Gly Ser Lys Gly Leu  Pro Gly Ile 
    1400                 1405                 1410             


Pro Gly  Lys Asp Gly Pro Ser  Gly Leu Pro Gly Pro  Pro Gly Ala 
    1415                 1420                 1425             


Leu Gly  Asp Pro Gly Leu Pro  Gly Leu Gln Gly Pro  Pro Gly Phe 
    1430                 1435                 1440             


Glu Gly  Ala Pro Gly Gln Gln  Gly Pro Phe Gly Met  Pro Gly Met 
    1445                 1450                 1455             


Pro Gly  Gln Ser Met Arg Val  Gly Tyr Xaa Leu Val  Lys His Ser 
    1460                 1465                 1470             


Gln Ser  Glu Gln Val Pro Pro  Cys Pro Ile Gly Met  Ser Gln Leu 
    1475                 1480                 1485             


Trp Val  Gly Tyr Ser Leu Leu  Phe Val Glu Gly Gln  Glu Lys Ala 
    1490                 1495                 1500             


His Asn  Gln Asp Leu Gly Phe  Ala Gly Ser Cys Leu  Pro Arg Phe 
    1505                 1510                 1515             


Ser Xaa  Met Pro Phe Ile Tyr  Cys Asn Ile Asn Glu  Val Cys His 
    1520                 1525                 1530             


Tyr Ala  Arg Arg Asn Asp Lys  Ser Tyr Trp Leu Ser  Xaa Xaa Ala 
    1535                 1540                 1545             


Pro Ile  Pro Met Met Pro Val  Ser Gln Xaa Gln Ile  Pro Gln Tyr 
    1550                 1555                 1560             


Ile Ser  Arg Cys Ser Val Cys  Glu Ala Pro Ser Gln  Ala Ile Ala 
    1565                 1570                 1575             


Val His  Ser Gln Asp Ile Xaa  Ile Pro Gln Cys Pro  Leu Gly Trp 
    1580                 1585                 1590             


Arg Ser  Leu Trp Ile Gly Tyr  Ser Phe Leu Met His  Xaa Ala Ala 
    1595                 1600                 1605             


Gly Ala  Glu Gly Gly Gly Gln  Ser Leu Val Ser Pro  Gly Ser Cys 
    1610                 1615                 1620             


Leu Glu  Asp Phe Arg Ala Xaa  Pro Phe Ile Glu Cys  Ser Gly Ala 
    1625                 1630                 1635             


Arg Gly  Xaa Cys His Tyr Phe  Ala Asn Lys Tyr Ser  Phe Trp Leu 
    1640                 1645                 1650             


Xaa Xaa  Val Glu Glu Arg Gln  Gln Phe Gly Glu Leu  Pro Val Ser 
    1655                 1660                 1665             


Glu Xaa  Leu Lys Ala Gly Gln  Leu His Xaa Arg Val  Ser Arg Cys 
    1670                 1675                 1680             


Gln Val  Cys Met Lys Ser Leu  
    1685                 1690 


<210> 6675
<211> 1707
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (830)..(830)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1090)..(1090)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1198)..(1198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1385)..(1385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1387)..(1387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1410)..(1410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1485)..(1485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1537)..(1537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1563)..(1564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1575)..(1575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1602)..(1602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1623)..(1623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1647)..(1647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1658)..(1658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1671)..(1672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1687)..(1687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1695)..(1695)
<223> Selenocysteine

<400> 6675
Met His Pro Gly Leu Trp Leu Leu Leu Val Xaa Leu Cys Leu Xaa Glu 
1               5                   10                  15      


Glu Leu Ala Ala Ala Gly Glu Lys Ser Tyr Gly Lys Pro Cys Gly Gly 
            20                  25                  30          


Gln Asp Cys Ser Gly Ser Cys Gln Cys Phe Pro Glu Lys Gly Ala Arg 
        35                  40                  45              


Gly Arg Pro Gly Pro Ile Gly Ile Gln Gly Pro Xaa Gly Pro Gln Gly 
    50                  55                  60                  


Phe Xaa Gly Ser Xaa Gly Leu Ser Gly Leu Lys Gly Glu Arg Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Leu Gly Pro Tyr Gly Pro Lys Gly Asp Lys Gly Pro Met 
                85                  90                  95      


Gly Val Pro Gly Phe Leu Gly Ile Asn Gly Ile Pro Gly His Pro Gly 
            100                 105                 110         


Gln Pro Gly Pro Arg Gly Pro Pro Gly Leu Asp Gly Cys Asn Gly Xaa 
        115                 120                 125             


Gln Gly Ala Val Gly Phe Pro Gly Pro Asp Gly Tyr Pro Gly Leu Leu 
    130                 135                 140                 


Gly Pro Pro Gly Leu Pro Gly Gln Lys Gly Ser Lys Gly Asp Pro Val 
145                 150                 155                 160 


Leu Ala Pro Gly Ser Phe Lys Gly Met Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Leu Asp Gly Ile Xaa Gly Pro Gln Gly Ala Pro Gly Phe Pro Gly 
            180                 185                 190         


Ala Val Gly Pro Ala Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Pro Leu Gly Pro Asp Gly Asn Met Gly Leu Gly Phe Gln Gly 
    210                 215                 220                 


Glu Lys Gly Val Lys Gly Asp Val Gly Leu Pro Gly Pro Ala Gly Pro 
225                 230                 235                 240 


Pro Pro Ser Xaa Gly Glu Leu Glu Phe Met Gly Phe Pro Lys Gly Lys 
                245                 250                 255     


Lys Gly Ser Lys Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Ile Ser 
            260                 265                 270         


Gly Pro Pro Gly Phe Pro Gly Leu Gly Xaa Xaa Gly Glu Lys Gly Glu 
        275                 280                 285             


Lys Gly Glu Lys Gly Ile Pro Gly Leu Pro Gly Pro Arg Gly Pro Met 
    290                 295                 300                 


Gly Ser Glu Gly Val Gln Gly Pro Pro Gly Gln Gln Gly Lys Lys Gly 
305                 310                 315                 320 


Xaa Leu Gly Phe Pro Gly Leu Asn Gly Phe Gln Gly Ile Glu Gly Gln 
                325                 330                 335     


Lys Gly Asp Ile Gly Leu Pro Gly Pro Asp Val Phe Ile Asp Ile Asp 
            340                 345                 350         


Gly Ala Val Ile Ser Gly Asn Pro Gly Asp Pro Gly Val Pro Gly Leu 
        355                 360                 365             


Pro Gly Leu Lys Gly Asp Glu Gly Ile Gln Gly Leu Arg Gly Pro Ser 
    370                 375                 380                 


Gly Val Pro Gly Leu Pro Ala Leu Ser Gly Val Pro Gly Ala Leu Gly 
385                 390                 395                 400 


Pro Gln Gly Phe Pro Gly Leu Lys Gly Asp Gln Gly Asn Pro Gly Arg 
                405                 410                 415     


Xaa Xaa Ile Gly Ala Ala Gly Leu Pro Gly Arg Asp Gly Leu Pro Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Pro Pro Ser Pro Glu Phe Glu Xaa Glu Xaa 
        435                 440                 445             


Leu His Asn Lys Glu Ser Gly Phe Pro Gly Leu Arg Gly Glu Gln Gly 
    450                 455                 460                 


Pro Lys Gly Asn Leu Gly Leu Lys Gly Ile Lys Gly Asp Ser Gly Phe 
465                 470                 475                 480 


Cys Ala Cys Asp Gly Gly Val Pro Asn Xaa Gly Pro Pro Gly Glu Pro 
                485                 490                 495     


Gly Pro Pro Gly Pro Trp Gly Leu Ile Gly Leu Pro Gly Leu Lys Gly 
            500                 505                 510         


Ala Arg Gly Asp Arg Gly Ser Gly Gly Ala Gln Gly Pro Ala Gly Ala 
        515                 520                 525             


Pro Gly Leu Val Gly Pro Leu Gly Pro Ser Gly Pro Lys Gly Lys Lys 
    530                 535                 540                 


Gly Glu Pro Ile Leu Ser Xaa Ile Gln Gly Met Pro Gly Asp Arg Gly 
545                 550                 555                 560 


Asp Ser Gly Ser Gln Gly Phe Arg Gly Val Ile Gly Glu Pro Gly Lys 
                565                 570                 575     


Asp Gly Val Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Asp Gly 
            580                 585                 590         


Gly Gln Gly Phe Pro Gly Glu Lys Gly Leu Pro Gly Leu Pro Gly Glu 
        595                 600                 605             


Lys Gly His Pro Gly Pro Pro Gly Leu Pro Gly Asn Gly Leu Pro Gly 
    610                 615                 620                 


Leu Pro Gly Pro Arg Gly Leu Pro Gly Asp Lys Gly Lys Asp Gly Leu 
625                 630                 635                 640 


Pro Gly Gln Gln Gly Leu Pro Gly Ser Lys Gly Asp Cys Cys Cys Arg 
                645                 650                 655     


Glu Val Gly Lys Gly Asp Leu Asp Xaa Glu Arg Gly Ile Xaa Leu Pro 
            660                 665                 670         


Cys Ile Ile Pro Gly Ser Tyr Gly Pro Ser Gly Phe Pro Gly Xaa Pro 
        675                 680                 685             


Gly Phe Pro Gly Pro Lys Gly Ser Arg Gly Leu Pro Gly Xaa Pro Gly 
    690                 695                 700                 


Gln Pro Gly Ser Ser Gly Ser Lys Gly Glu Pro Gly Ser Pro Gly Leu 
705                 710                 715                 720 


Val His Leu Pro Glu Leu Pro Gly Phe Pro Gly Pro Arg Gly Glu Lys 
                725                 730                 735     


Gly Leu Pro Gly Phe Pro Gly Leu Pro Gly Lys Asp Gly Leu Pro Gly 
            740                 745                 750         


Met Ile Gly Ser Pro Gly Leu Pro Gly Ser Lys Gly Ala Xaa Gly Asp 
        755                 760                 765             


Ile Phe Gly Ala Glu Asn Gly Ala Pro Gly Glu Gln Gly Leu Gln Gly 
    770                 775                 780                 


Leu Xaa Gly His Lys Gly Phe Leu Gly Asp Ser Gly Leu Pro Gly Leu 
785                 790                 795                 800 


Lys Gly Val His Gly Lys Pro Gly Leu Leu Gly Pro Lys Gly Glu Arg 
                805                 810                 815     


Gly Ser Pro Gly Xaa Pro Gly Gln Val Gly Gln Pro Gly Xaa Pro Gly 
            820                 825                 830         


Ser Ser Gly Pro Tyr Gly Ile Lys Gly Lys Ser Gly Leu Pro Gly Ala 
        835                 840                 845             


Pro Gly Phe Pro Gly Ile Ser Gly His Pro Gly Lys Lys Gly Xaa Arg 
    850                 855                 860                 


Gly Lys Lys Gly Pro Pro Gly Ser Ile Val Lys Lys Gly Leu Pro Gly 
865                 870                 875                 880 


Leu Lys Gly Leu Pro Gly Asn Pro Gly Leu Val Gly Leu Lys Gly Ser 
                885                 890                 895     


Pro Gly Ser Pro Gly Val Ala Gly Leu Pro Ala Leu Ser Gly Pro Lys 
            900                 905                 910         


Gly Glu Lys Gly Ser Val Gly Phe Val Gly Phe Pro Gly Ile Pro Gly 
        915                 920                 925             


Leu Pro Gly Ile Pro Gly Xaa Arg Gly Leu Lys Gly Ile Pro Gly Ser 
    930                 935                 940                 


Xaa Gly Lys Met Gly Pro Ser Gly Arg Ala Gly Xaa Pro Gly Glu Lys 
945                 950                 955                 960 


Gly Asp Arg Gly Asn Pro Gly Pro Val Gly Ile Pro Ser Pro Arg Arg 
                965                 970                 975     


Pro Met Ser Asn Leu Trp Leu Lys Gly Asp Lys Gly Ser Gln Gly Ser 
            980                 985                 990         


Ala Gly Ser Asn Gly Phe Pro Gly  Pro Arg Gly Asp Lys  Gly Glu Ala 
        995                 1000                 1005             


Gly Arg  Pro Gly Pro Pro Gly  Leu Pro Gly Ala Pro  Gly Leu Pro 
    1010                 1015                 1020             


Gly Ile  Ile Lys Gly Val Ser  Gly Lys Pro Gly Pro  Pro Gly Phe 
    1025                 1030                 1035             


Met Gly  Ile Arg Gly Leu Pro  Gly Leu Lys Gly Ser  Ser Gly Ile 
    1040                 1045                 1050             


Xaa Gly  Phe Pro Gly Met Pro  Gly Glu Ser Gly Ser  Gln Gly Ile 
    1055                 1060                 1065             


Arg Gly  Ser Pro Gly Leu Pro  Gly Ala Ser Gly Leu  Pro Gly Leu 
    1070                 1075                 1080             


Lys Gly  Asp Asn Gly Gln Xaa  Val Glu Ile Ser Gly  Ser Pro Gly 
    1085                 1090                 1095             


Pro Lys  Gly Gln Pro Gly Glu  Ser Gly Phe Lys Gly  Xaa Lys Gly 
    1100                 1105                 1110             


Arg Asp  Gly Leu Ile Gly Asn  Ile Gly Phe Pro Gly  Asn Lys Gly 
    1115                 1120                 1125             


Glu Asp  Gly Lys Val Gly Val  Ser Gly Asp Val Gly  Leu Pro Gly 
    1130                 1135                 1140             


Ala Pro  Gly Phe Pro Gly Val  Ala Gly Met Arg Gly  Glu Pro Gly 
    1145                 1150                 1155             


Leu Pro  Gly Ser Ser Gly His  Gln Gly Ala Ile Gly  Pro Leu Gly 
    1160                 1165                 1170             


Ser Pro  Gly Leu Ile Gly Pro  Lys Gly Phe Pro Gly  Phe Pro Gly 
    1175                 1180                 1185             


Leu His  Gly Leu Asn Gly Leu  Pro Gly Xaa Lys Gly  Xaa His Gly 
    1190                 1195                 1200             


Xaa Pro  Gly Pro Ser Ile Xaa  Gly Val Pro Gly Pro  Ala Gly Leu 
    1205                 1210                 1215             


Pro Gly  Pro Lys Gly Glu Lys  Gly Tyr Pro Gly Ile  Gly Ile Gly 
    1220                 1225                 1230             


Ala Pro  Gly Lys Pro Gly Leu  Arg Gly Gln Lys Gly  Asp Arg Gly 
    1235                 1240                 1245             


Phe Pro  Gly Leu Gln Gly Pro  Ala Gly Leu Pro Gly  Ala Pro Gly 
    1250                 1255                 1260             


Ile Ser  Leu Pro Ser Leu Ile  Ala Gly Gln Pro Gly  Asp Pro Gly 
    1265                 1270                 1275             


Arg Pro  Gly Leu Asp Gly Glu  Arg Gly Arg Pro Gly  Pro Ala Gly 
    1280                 1285                 1290             


Pro Pro  Gly Pro Pro Gly Pro  Ser Ser Asn Gln Gly  Asp Xaa Gly 
    1295                 1300                 1305             


Asp Pro  Gly Phe Pro Gly Ile  Pro Gly Pro Lys Gly  Pro Lys Gly 
    1310                 1315                 1320             


Asp Gln  Gly Ile Pro Gly Phe  Ser Gly Leu Pro Gly  Glu Leu Gly 
    1325                 1330                 1335             


Leu Lys  Gly Met Arg Gly Glu  Pro Gly Phe Met Gly  Xaa Pro Gly 
    1340                 1345                 1350             


Lys Val  Gly Pro Pro Gly Asp  Pro Gly Phe Pro Gly  Met Lys Gly 
    1355                 1360                 1365             


Lys Ala  Gly Pro Arg Gly Ser  Ser Gly Leu Gln Gly  Asp Pro Gly 
    1370                 1375                 1380             


Gln Xaa  Pro Xaa Ala Glu Ala  Val Gln Val Pro Pro  Gly Pro Leu 
    1385                 1390                 1395             


Gly Leu  Pro Gly Ile Asp Gly  Ile Pro Gly Leu Xaa  Gly Asp Pro 
    1400                 1405                 1410             


Gly Ala  Gln Gly Pro Val Gly  Leu Gln Gly Ser Lys  Gly Leu Pro 
    1415                 1420                 1425             


Gly Ile  Pro Gly Lys Asp Gly  Pro Ser Gly Leu Pro  Gly Pro Pro 
    1430                 1435                 1440             


Gly Ala  Leu Gly Asp Pro Gly  Leu Pro Gly Leu Gln  Gly Pro Pro 
    1445                 1450                 1455             


Gly Phe  Glu Gly Ala Pro Gly  Gln Gln Gly Pro Phe  Gly Met Pro 
    1460                 1465                 1470             


Gly Met  Pro Gly Gln Ser Met  Arg Val Gly Tyr Xaa  Leu Val Lys 
    1475                 1480                 1485             


His Ser  Gln Ser Glu Gln Val  Pro Pro Cys Pro Ile  Gly Met Ser 
    1490                 1495                 1500             


Gln Leu  Trp Val Gly Tyr Ser  Leu Leu Phe Val Glu  Gly Gln Glu 
    1505                 1510                 1515             


Lys Ala  His Asn Gln Asp Leu  Gly Phe Ala Gly Ser  Cys Leu Pro 
    1520                 1525                 1530             


Arg Phe  Ser Xaa Met Pro Phe  Ile Tyr Cys Asn Ile  Asn Glu Val 
    1535                 1540                 1545             


Cys His  Tyr Ala Arg Arg Asn  Asp Lys Ser Tyr Trp  Leu Ser Xaa 
    1550                 1555                 1560             


Xaa Ala  Pro Ile Pro Met Met  Pro Val Ser Gln Xaa  Gln Ile Pro 
    1565                 1570                 1575             


Gln Tyr  Ile Ser Arg Cys Ser  Val Cys Glu Ala Pro  Ser Gln Ala 
    1580                 1585                 1590             


Ile Ala  Val His Ser Gln Asp  Ile Xaa Ile Pro Gln  Cys Pro Leu 
    1595                 1600                 1605             


Gly Trp  Arg Ser Leu Trp Ile  Gly Tyr Ser Phe Leu  Met His Xaa 
    1610                 1615                 1620             


Ala Ala  Gly Ala Glu Gly Gly  Gly Gln Ser Leu Val  Ser Pro Gly 
    1625                 1630                 1635             


Ser Cys  Leu Glu Asp Phe Arg  Ala Xaa Pro Phe Ile  Glu Cys Ser 
    1640                 1645                 1650             


Gly Ala  Arg Gly Xaa Cys His  Tyr Phe Ala Asn Lys  Tyr Ser Phe 
    1655                 1660                 1665             


Trp Leu  Xaa Xaa Val Glu Glu  Arg Gln Gln Phe Gly  Glu Leu Pro 
    1670                 1675                 1680             


Val Ser  Glu Xaa Leu Lys Ala  Gly Gln Leu His Xaa  Arg Val Ser 
    1685                 1690                 1695             


Arg Cys  Gln Val Cys Met Lys  Ser Leu 
    1700                 1705         


<210> 6676
<211> 1691
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (919)..(919)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1188)..(1188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1291)..(1291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1369)..(1369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1394)..(1394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1469)..(1469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1521)..(1521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1547)..(1548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1559)..(1559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1631)..(1631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1642)..(1642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1655)..(1656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1671)..(1671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1679)..(1679)
<223> Selenocysteine

<400> 6676
Met Leu Ile Asn Lys Leu Trp Leu Leu Leu Val Xaa Leu Cys Leu Xaa 
1               5                   10                  15      


Glu Glu Leu Ala Ala Ala Gly Glu Lys Ser Tyr Gly Lys Pro Cys Gly 
            20                  25                  30          


Gly Gln Asp Cys Ser Gly Ser Cys Gln Cys Phe Pro Glu Lys Gly Ala 
        35                  40                  45              


Arg Gly Arg Pro Gly Pro Ile Gly Ile Gln Gly Pro Xaa Gly Pro Gln 
    50                  55                  60                  


Gly Phe Xaa Gly Ser Xaa Gly Leu Ser Gly Leu Lys Gly Glu Arg Gly 
65                  70                  75                  80  


Phe Pro Gly Leu Leu Gly Pro Tyr Gly Pro Lys Gly Asp Lys Gly Pro 
                85                  90                  95      


Met Gly Val Pro Gly Phe Leu Gly Ile Asn Gly Ile Pro Gly His Pro 
            100                 105                 110         


Gly Gln Pro Gly Pro Arg Gly Pro Pro Gly Leu Asp Gly Cys Asn Gly 
        115                 120                 125             


Xaa Gln Gly Ala Val Gly Phe Pro Gly Pro Asp Gly Tyr Pro Gly Leu 
    130                 135                 140                 


Leu Gly Pro Pro Gly Leu Pro Gly Gln Lys Gly Ser Lys Gly Asp Pro 
145                 150                 155                 160 


Val Leu Ala Pro Gly Ser Phe Lys Gly Met Lys Gly Asp Pro Gly Leu 
                165                 170                 175     


Pro Gly Leu Asp Gly Ile Xaa Gly Pro Gln Gly Ala Pro Gly Phe Pro 
            180                 185                 190         


Gly Ala Val Gly Pro Ala Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly 
        195                 200                 205             


Pro Pro Gly Pro Leu Gly Pro Asp Gly Asn Met Gly Leu Gly Phe Gln 
    210                 215                 220                 


Gly Glu Lys Gly Val Lys Gly Asp Val Gly Leu Pro Gly Pro Ala Gly 
225                 230                 235                 240 


Pro Pro Pro Ser Xaa Gly Glu Leu Glu Phe Met Gly Phe Pro Lys Gly 
                245                 250                 255     


Lys Lys Gly Ser Lys Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Ile 
            260                 265                 270         


Ser Gly Pro Pro Gly Phe Pro Gly Leu Gly Xaa Xaa Gly Glu Lys Gly 
        275                 280                 285             


Glu Lys Gly Glu Lys Gly Ile Pro Gly Leu Pro Gly Pro Arg Gly Pro 
    290                 295                 300                 


Met Gly Ser Glu Gly Val Gln Gly Pro Pro Gly Gln Gln Gly Lys Lys 
305                 310                 315                 320 


Gly Xaa Leu Gly Phe Pro Gly Leu Asn Gly Phe Gln Gly Ile Glu Gly 
                325                 330                 335     


Gln Lys Gly Asp Ile Gly Leu Pro Gly Pro Asp Val Phe Ile Asp Ile 
            340                 345                 350         


Asp Gly Ala Val Ile Ser Gly Asn Pro Gly Asp Pro Gly Val Pro Gly 
        355                 360                 365             


Leu Pro Gly Leu Lys Gly Asp Glu Gly Ile Gln Gly Leu Arg Gly Pro 
    370                 375                 380                 


Ser Gly Val Pro Gly Leu Pro Ala Leu Ser Gly Val Pro Gly Ala Leu 
385                 390                 395                 400 


Gly Pro Gln Gly Phe Pro Gly Leu Lys Gly Asp Gln Gly Asn Pro Gly 
                405                 410                 415     


Arg Xaa Xaa Ile Gly Ala Ala Gly Leu Pro Gly Arg Asp Gly Leu Pro 
            420                 425                 430         


Gly Pro Pro Gly Pro Pro Gly Pro Pro Ser Pro Glu Phe Glu Xaa Glu 
        435                 440                 445             


Xaa Leu His Asn Lys Glu Ser Gly Phe Pro Gly Leu Arg Gly Glu Gln 
    450                 455                 460                 


Gly Pro Lys Gly Asn Leu Gly Leu Lys Gly Ile Lys Gly Asp Ser Gly 
465                 470                 475                 480 


Phe Cys Ala Cys Asp Gly Gly Val Pro Asn Xaa Gly Pro Pro Gly Glu 
                485                 490                 495     


Pro Gly Pro Pro Gly Pro Trp Gly Leu Ile Gly Leu Pro Gly Leu Lys 
            500                 505                 510         


Gly Ala Arg Gly Asp Arg Gly Ser Gly Gly Ala Gln Gly Pro Ala Gly 
        515                 520                 525             


Ala Pro Gly Leu Val Gly Pro Leu Gly Pro Ser Gly Pro Lys Gly Lys 
    530                 535                 540                 


Lys Gly Glu Pro Ile Leu Ser Xaa Ile Gln Gly Met Pro Gly Asp Arg 
545                 550                 555                 560 


Gly Asp Ser Gly Ser Gln Gly Phe Arg Gly Val Ile Gly Glu Pro Gly 
                565                 570                 575     


Lys Asp Gly Val Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Asp 
            580                 585                 590         


Gly Gly Gln Gly Phe Pro Gly Glu Lys Gly Leu Pro Gly Leu Pro Gly 
        595                 600                 605             


Glu Lys Gly His Pro Gly Pro Pro Gly Leu Pro Gly Asn Gly Leu Pro 
    610                 615                 620                 


Gly Leu Pro Gly Pro Arg Gly Leu Pro Gly Asp Lys Gly Lys Asp Gly 
625                 630                 635                 640 


Leu Pro Gly Gln Gln Gly Leu Pro Gly Ser Lys Gly Ile Xaa Leu Pro 
                645                 650                 655     


Cys Ile Ile Pro Gly Ser Tyr Gly Pro Ser Gly Phe Pro Gly Xaa Pro 
            660                 665                 670         


Gly Phe Pro Gly Pro Lys Gly Ser Arg Gly Leu Pro Gly Xaa Pro Gly 
        675                 680                 685             


Gln Pro Gly Ser Ser Gly Ser Lys Gly Glu Pro Gly Ser Pro Gly Leu 
    690                 695                 700                 


Val His Leu Pro Glu Leu Pro Gly Phe Pro Gly Pro Arg Gly Glu Lys 
705                 710                 715                 720 


Gly Leu Pro Gly Phe Pro Gly Leu Pro Gly Lys Asp Gly Leu Pro Gly 
                725                 730                 735     


Met Ile Gly Ser Pro Gly Leu Pro Gly Ser Lys Gly Ala Xaa Gly Asp 
            740                 745                 750         


Ile Phe Gly Ala Glu Asn Gly Ala Pro Gly Glu Gln Gly Leu Gln Gly 
        755                 760                 765             


Leu Xaa Gly His Lys Gly Phe Leu Gly Asp Ser Gly Leu Pro Gly Leu 
    770                 775                 780                 


Lys Gly Val His Gly Lys Pro Gly Leu Leu Gly Pro Lys Gly Glu Arg 
785                 790                 795                 800 


Gly Ser Pro Gly Xaa Pro Gly Gln Val Gly Gln Pro Gly Xaa Pro Gly 
                805                 810                 815     


Ser Ser Gly Pro Tyr Gly Ile Lys Gly Lys Ser Gly Leu Pro Gly Ala 
            820                 825                 830         


Pro Gly Phe Pro Gly Ile Ser Gly His Pro Gly Lys Lys Gly Xaa Arg 
        835                 840                 845             


Gly Lys Lys Gly Pro Pro Gly Ser Ile Val Lys Lys Gly Leu Pro Gly 
    850                 855                 860                 


Leu Lys Gly Leu Pro Gly Asn Pro Gly Leu Val Gly Leu Lys Gly Ser 
865                 870                 875                 880 


Pro Gly Ser Pro Gly Val Ala Gly Leu Pro Ala Leu Ser Gly Pro Lys 
                885                 890                 895     


Gly Glu Lys Gly Ser Val Gly Phe Val Gly Phe Pro Gly Ile Pro Gly 
            900                 905                 910         


Leu Pro Gly Ile Pro Gly Xaa Arg Gly Leu Lys Gly Ile Pro Gly Ser 
        915                 920                 925             


Xaa Gly Lys Met Gly Pro Ser Gly Arg Ala Gly Xaa Pro Gly Glu Lys 
    930                 935                 940                 


Gly Asp Arg Gly Asn Pro Gly Pro Val Gly Ile Pro Ser Pro Arg Arg 
945                 950                 955                 960 


Pro Met Ser Asn Leu Trp Leu Lys Gly Asp Lys Gly Ser Gln Gly Ser 
                965                 970                 975     


Ala Gly Ser Asn Gly Phe Pro Gly Pro Arg Gly Asp Lys Gly Glu Ala 
            980                 985                 990         


Gly Arg Pro Gly Pro Pro Gly Leu  Pro Gly Ala Pro Gly  Leu Pro Gly 
        995                 1000                 1005             


Ile Ile  Lys Gly Val Ser Gly  Lys Pro Gly Pro Pro  Gly Phe Met 
    1010                 1015                 1020             


Gly Ile  Arg Gly Leu Pro Gly  Leu Lys Gly Ser Ser  Gly Ile Xaa 
    1025                 1030                 1035             


Gly Phe  Pro Gly Met Pro Gly  Glu Ser Gly Ser Gln  Gly Ile Arg 
    1040                 1045                 1050             


Gly Ser  Pro Gly Leu Pro Gly  Ala Ser Gly Leu Pro  Gly Leu Lys 
    1055                 1060                 1065             


Gly Asp  Asn Gly Gln Xaa Val  Glu Ile Ser Gly Ser  Pro Gly Pro 
    1070                 1075                 1080             


Lys Gly  Gln Pro Gly Glu Ser  Gly Phe Lys Gly Xaa  Lys Gly Arg 
    1085                 1090                 1095             


Asp Gly  Leu Ile Gly Asn Ile  Gly Phe Pro Gly Asn  Lys Gly Glu 
    1100                 1105                 1110             


Asp Gly  Lys Val Gly Val Ser  Gly Asp Val Gly Leu  Pro Gly Ala 
    1115                 1120                 1125             


Pro Gly  Phe Pro Gly Val Ala  Gly Met Arg Gly Glu  Pro Gly Leu 
    1130                 1135                 1140             


Pro Gly  Ser Ser Gly His Gln  Gly Ala Ile Gly Pro  Leu Gly Ser 
    1145                 1150                 1155             


Pro Gly  Leu Ile Gly Pro Lys  Gly Phe Pro Gly Phe  Pro Gly Leu 
    1160                 1165                 1170             


His Gly  Leu Asn Gly Leu Pro  Gly Xaa Lys Gly Xaa  His Gly Xaa 
    1175                 1180                 1185             


Pro Gly  Pro Ser Ile Xaa Gly  Val Pro Gly Pro Ala  Gly Leu Pro 
    1190                 1195                 1200             


Gly Pro  Lys Gly Glu Lys Gly  Tyr Pro Gly Ile Gly  Ile Gly Ala 
    1205                 1210                 1215             


Pro Gly  Lys Pro Gly Leu Arg  Gly Gln Lys Gly Asp  Arg Gly Phe 
    1220                 1225                 1230             


Pro Gly  Leu Gln Gly Pro Ala  Gly Leu Pro Gly Ala  Pro Gly Ile 
    1235                 1240                 1245             


Ser Leu  Pro Ser Leu Ile Ala  Gly Gln Pro Gly Asp  Pro Gly Arg 
    1250                 1255                 1260             


Pro Gly  Leu Asp Gly Glu Arg  Gly Arg Pro Gly Pro  Ala Gly Pro 
    1265                 1270                 1275             


Pro Gly  Pro Pro Gly Pro Ser  Ser Asn Gln Gly Asp  Xaa Gly Asp 
    1280                 1285                 1290             


Pro Gly  Phe Pro Gly Ile Pro  Gly Pro Lys Gly Pro  Lys Gly Asp 
    1295                 1300                 1305             


Gln Gly  Ile Pro Gly Phe Ser  Gly Leu Pro Gly Glu  Leu Gly Leu 
    1310                 1315                 1320             


Lys Gly  Met Arg Gly Glu Pro  Gly Phe Met Gly Xaa  Pro Gly Lys 
    1325                 1330                 1335             


Val Gly  Pro Pro Gly Asp Pro  Gly Phe Pro Gly Met  Lys Gly Lys 
    1340                 1345                 1350             


Ala Gly  Pro Arg Gly Ser Ser  Gly Leu Gln Gly Asp  Pro Gly Gln 
    1355                 1360                 1365             


Xaa Pro  Xaa Ala Glu Ala Val  Gln Val Pro Pro Gly  Pro Leu Gly 
    1370                 1375                 1380             


Leu Pro  Gly Ile Asp Gly Ile  Pro Gly Leu Xaa Gly  Asp Pro Gly 
    1385                 1390                 1395             


Ala Gln  Gly Pro Val Gly Leu  Gln Gly Ser Lys Gly  Leu Pro Gly 
    1400                 1405                 1410             


Ile Pro  Gly Lys Asp Gly Pro  Ser Gly Leu Pro Gly  Pro Pro Gly 
    1415                 1420                 1425             


Ala Leu  Gly Asp Pro Gly Leu  Pro Gly Leu Gln Gly  Pro Pro Gly 
    1430                 1435                 1440             


Phe Glu  Gly Ala Pro Gly Gln  Gln Gly Pro Phe Gly  Met Pro Gly 
    1445                 1450                 1455             


Met Pro  Gly Gln Ser Met Arg  Val Gly Tyr Xaa Leu  Val Lys His 
    1460                 1465                 1470             


Ser Gln  Ser Glu Gln Val Pro  Pro Cys Pro Ile Gly  Met Ser Gln 
    1475                 1480                 1485             


Leu Trp  Val Gly Tyr Ser Leu  Leu Phe Val Glu Gly  Gln Glu Lys 
    1490                 1495                 1500             


Ala His  Asn Gln Asp Leu Gly  Phe Ala Gly Ser Cys  Leu Pro Arg 
    1505                 1510                 1515             


Phe Ser  Xaa Met Pro Phe Ile  Tyr Cys Asn Ile Asn  Glu Val Cys 
    1520                 1525                 1530             


His Tyr  Ala Arg Arg Asn Asp  Lys Ser Tyr Trp Leu  Ser Xaa Xaa 
    1535                 1540                 1545             


Ala Pro  Ile Pro Met Met Pro  Val Ser Gln Xaa Gln  Ile Pro Gln 
    1550                 1555                 1560             


Tyr Ile  Ser Arg Cys Ser Val  Cys Glu Ala Pro Ser  Gln Ala Ile 
    1565                 1570                 1575             


Ala Val  His Ser Gln Asp Ile  Xaa Ile Pro Gln Cys  Pro Leu Gly 
    1580                 1585                 1590             


Trp Arg  Ser Leu Trp Ile Gly  Tyr Ser Phe Leu Met  His Xaa Ala 
    1595                 1600                 1605             


Ala Gly  Ala Glu Gly Gly Gly  Gln Ser Leu Val Ser  Pro Gly Ser 
    1610                 1615                 1620             


Cys Leu  Glu Asp Phe Arg Ala  Xaa Pro Phe Ile Glu  Cys Ser Gly 
    1625                 1630                 1635             


Ala Arg  Gly Xaa Cys His Tyr  Phe Ala Asn Lys Tyr  Ser Phe Trp 
    1640                 1645                 1650             


Leu Xaa  Xaa Val Glu Glu Arg  Gln Gln Phe Gly Glu  Leu Pro Val 
    1655                 1660                 1665             


Ser Glu  Xaa Leu Lys Ala Gly  Gln Leu His Xaa Arg  Val Ser Arg 
    1670                 1675                 1680             


Cys Gln  Val Cys Met Lys Ser  Leu 
    1685                 1690     


<210> 6677
<211> 742
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<400> 6677
Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 
1               5                   10                  15      


Lys Arg Phe Gly Ile Gln Glu Gly Xaa Gln Cys Xaa Lys Cys Lys Asn 
            20                  25                  30          


Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 
        35                  40                  45              


Leu Leu Xaa Ile Xaa Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys 
    50                  55                  60                  


Met Asp Asn Val Xaa Gly Gly Met Glu Xaa Ser Arg Gln Xaa Tyr Asp 
65                  70                  75                  80  


Asp Lys Leu Xaa Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
                85                  90                  95      


Xaa Gly Lys Lys Ala Ile Ser Xaa Asn Ser Glu Leu Ser Xaa Phe Arg 
            100                 105                 110         


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Xaa Glu Lys 
        115                 120                 125             


Xaa Ser Lys Asn Lys Asp Xaa Leu Glu Lys Leu Gln Ala Ser Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Xaa Leu Glu Asn Asn 
145                 150                 155                 160 


Ser Phe Leu Ile Xaa Xaa Val Asn Lys Xaa Leu Gln Ala Tyr Asn Gly 
                165                 170                 175     


Tyr Val Xaa Asn Leu Gln Gln Asp Xaa Ser Val Leu Gln Gly Asn Leu 
            180                 185                 190         


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
        195                 200                 205             


Leu Asn Leu Xaa Gln Val Gln Gln Arg Asn Leu Ile Xaa Asn Leu Gln 
    210                 215                 220                 


Arg Ser Val Asp Asp Xaa Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
225                 230                 235                 240 


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Xaa Asp 
                245                 250                 255     


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Xaa Leu Ala Ala Asn Asn 
            260                 265                 270         


Ser Ala Leu Ala Lys Ala Asn Asn Asp Xaa Leu Glu Asp Met Asn Ser 
        275                 280                 285             


Gln Leu Asn Ser Phe Xaa Gly Gln Met Glu Asn Ile Xaa Xaa Ile Ser 
    290                 295                 300                 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
305                 310                 315                 320 


Ala Glu Asn Arg Xaa Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
                325                 330                 335     


Gln Leu Phe Glu Xaa Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
            340                 345                 350         


Xaa Ala His His Leu Arg Xaa Leu Xaa Ser Asn Leu Asn Glu Val Arg 
        355                 360                 365             


Xaa Xaa Cys Xaa Asp Xaa Leu Xaa Lys His Xaa Asp Asp Leu Xaa Ser 
    370                 375                 380                 


Leu Asn Asn Xaa Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
385                 390                 395                 400 


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Xaa Glu Val Ala Asn 
                405                 410                 415     


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
            420                 425                 430         


Gln Leu Ile Lys Asn Phe Xaa Ile Leu Gln Gly Pro Pro Gly Pro Arg 
        435                 440                 445             


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Xaa Gly 
    450                 455                 460                 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
                485                 490                 495     


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
            500                 505                 510         


Ser Pro Gly Lys Pro Gly Pro Gln Gly Ser Ser Gly Asp Pro Gly Pro 
        515                 520                 525             


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
    530                 535                 540                 


Gly Phe Gln Gly Leu Gln Gly Xaa Val Gly Glu Pro Gly Val Pro Gly 
545                 550                 555                 560 


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
                565                 570                 575     


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
            580                 585                 590         


Ala Leu Gln Asn Glu Pro Xaa Pro Ala Pro Glu Asp Asn Gly Cys Pro 
        595                 600                 605             


Pro His Trp Lys Asn Phe Xaa Asp Lys Cys Tyr Tyr Phe Ser Val Glu 
    610                 615                 620                 


Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 
625                 630                 635                 640 


His Leu Val Phe Ile Asn Xaa Arg Glu Glu Gln Gln Trp Ile Lys Lys 
                645                 650                 655     


Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Xaa Asp Ser Glu 
            660                 665                 670         


Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Xaa Ser Pro Asp Tyr Lys 
        675                 680                 685             


Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro 
    690                 695                 700                 


Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe 
705                 710                 715                 720 


Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Xaa 
                725                 730                 735     


Val Leu Ser Ser Ala Leu 
            740         


<210> 6678
<211> 190
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<400> 6678
Met Ala Ala Gly Glu Leu Glu Gly Gly Lys Pro Leu Ser Gly Leu Leu 
1               5                   10                  15      


Asn Ala Leu Ala Gln Asp Xaa Phe His Gly Tyr Pro Gly Ile Xaa Glu 
            20                  25                  30          


Glu Leu Leu Arg Ser Gln Leu Tyr Pro Glu Val Pro Pro Glu Glu Phe 
        35                  40                  45              


Arg Pro Phe Leu Ala Lys Met Arg Gly Ile Leu Lys Ser Ile Ala Ser 
    50                  55                  60                  


Ala Asp Met Asp Phe Asn Gln Leu Glu Ala Phe Leu Xaa Ala Gln Xaa 
65                  70                  75                  80  


Lys Lys Gln Gly Gly Ile Xaa Ser Asp Gln Ala Ala Val Ile Ser Lys 
                85                  90                  95      


Phe Trp Lys Ser His Lys Xaa Lys Ile Arg Glu Ser Leu Met Asn Gln 
            100                 105                 110         


Ser Arg Trp Asn Ser Gly Leu Arg Gly Leu Ser Trp Arg Val Asp Gly 
        115                 120                 125             


Lys Ser Gln Ser Arg His Ser Ala Gln Ile His Xaa Pro Val Ala Ile 
    130                 135                 140                 


Ile Glu Leu Glu Leu Gly Lys Tyr Gly Gln Glu Ser Glu Phe Leu Cys 
145                 150                 155                 160 


Leu Glu Phe Asp Glu Val Lys Val Asn Gln Ile Leu Lys Xaa Leu Ser 
                165                 170                 175     


Glu Val Glu Glu Ser Ile Ser Xaa Leu Ile Ser Gln Pro Asn 
            180                 185                 190 


<210> 6679
<211> 98
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 6679
Met Ala Ala Gly Glu Leu Glu Gly Gly Lys Pro Leu Ser Gly Leu Leu 
1               5                   10                  15      


Asn Ala Leu Ala Gln Asp Xaa Phe His Gly Tyr Pro Gly Ile Xaa Glu 
            20                  25                  30          


Glu Leu Leu Arg Ser Gln Leu Tyr Pro Glu Val Pro Pro Glu Glu Phe 
        35                  40                  45              


Arg Pro Phe Leu Ala Lys Met Arg Gly Ile Leu Lys Xaa Gly Ser Cys 
    50                  55                  60                  


Cys Val Ala Gln Asp Arg Val Gln Trp Val Phe Ile Gly Xaa Ile Met 
65                  70                  75                  80  


Ala His Arg Gly Leu Glu Leu Leu Gly Ser Ser Asp Ser Pro Ala Ser 
                85                  90                  95      


Ala Ser 
        


<210> 6680
<211> 32
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<400> 6680
Xaa Cys Leu Glu Phe Asp Glu Val Lys Val Asn Gln Ile Leu Lys Xaa 
1               5                   10                  15      


Leu Ser Glu Val Glu Glu Ser Ile Ser Xaa Leu Ile Ser Gln Pro Asn 
            20                  25                  30          


<210> 6681
<211> 50
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<400> 6681
Xaa Pro Gly Ile Xaa Glu Glu Leu Leu Arg Ser Gln Leu Tyr Pro Glu 
1               5                   10                  15      


Val Pro Pro Glu Glu Phe Arg Pro Phe Leu Ala Lys Met Arg Gly Ile 
            20                  25                  30          


Leu Lys Arg Gln Asn Leu Pro Ile Ser Ser Arg Val Val Ser Asn Ser 
        35                  40                  45              


Trp Ala 
    50  


<210> 6682
<211> 38
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<400> 6682
Xaa Gln Glu Ser Glu Phe Leu Cys Leu Glu Phe Asp Glu Val Lys Val 
1               5                   10                  15      


Asn Gln Ile Leu Lys Xaa Leu Ser Glu Val Glu Glu Ser Ile Ser Xaa 
            20                  25                  30          


Leu Ile Ser Gln Pro Asn 
        35              


<210> 6683
<211> 39
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 6683
Met Glu Ala Ser Ser Glu Pro Pro Leu Asp Ala Lys Ser Asp Val Ser 
1               5                   10                  15      


Ser Asn Leu Glu Gly Glu Phe Ser Val Glu Xaa Gly Tyr Gly Cys Glu 
            20                  25                  30          


Leu Arg His Leu Gln Ile Ser 
        35                  


<210> 6684
<211> 85
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<400> 6684
Met Glu Ala Ser Ser Glu Pro Pro Leu Asp Ala Lys Ser Asp Val Xaa 
1               5                   10                  15      


Asn Gln Leu Val Asp Phe Gln Trp Lys Leu Gly Met Ala Val Ser Ser 
            20                  25                  30          


Asp Xaa Cys Arg Ser Leu Lys Tyr Pro Tyr Val Ala Val Met Leu Lys 
        35                  40                  45              


Val Ala Asp His Ser Gly Gln Val Lys Xaa Lys Cys Phe Glu Met Xaa 
    50                  55                  60                  


Ile Pro Gln Phe Gln Asn Phe Tyr Arg Gln Phe Lys Glu Ile Ala Ala 
65                  70                  75                  80  


Val Ile Glu Xaa Val 
                85  


<210> 6685
<211> 98
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<400> 6685
Met Glu Ala Ser Ser Glu Pro Pro Leu Asp Ala Lys Ser Asp Val Xaa 
1               5                   10                  15      


Asn Gln Leu Val Asp Phe Gln Trp Lys Leu Gly Met Ala Val Ser Ser 
            20                  25                  30          


Asp Xaa Cys Arg Ser Leu Lys Tyr Pro Tyr Val Ala Val Met Leu Lys 
        35                  40                  45              


Val Ala Asp His Ser Gly Gln Val Lys Xaa Lys Cys Phe Glu Met Xaa 
    50                  55                  60                  


Ile Pro Gln Phe Gln Pro Gln Leu Leu Ala Xaa Ser Ser Leu Leu Ser 
65                  70                  75                  80  


Ala Ser Asn Phe Tyr Arg Gln Phe Lys Glu Ile Ala Ala Val Ile Glu 
                85                  90                  95      


Xaa Val 
        


<210> 6686
<211> 100
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<400> 6686
Met Lys Ala Pro Leu Pro His Pro Ala Leu Ala Arg Arg Met Gln Ile 
1               5                   10                  15      


Lys Asp Cys Trp Ala Leu Ile Arg Arg Gln Leu Phe Glu Ala Arg Asn 
            20                  25                  30          


Xaa Leu Val Asp Phe Gln Trp Lys Leu Gly Met Ala Val Ser Ser Asp 
        35                  40                  45              


Xaa Cys Arg Ser Leu Lys Tyr Pro Tyr Val Ala Val Met Leu Lys Val 
    50                  55                  60                  


Ala Asp His Ser Gly Gln Val Lys Xaa Lys Cys Phe Glu Met Xaa Ile 
65                  70                  75                  80  


Pro Gln Phe Gln Asn Phe Tyr Arg Gln Phe Lys Glu Ile Ala Ala Val 
                85                  90                  95      


Ile Glu Xaa Val 
            100 


<210> 6687
<211> 57
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<400> 6687
Met Gly Arg Leu His Cys Xaa Glu Asp Pro Val Pro Glu Ala Val Gly 
1               5                   10                  15      


Gly Asp Met Gln Gln Leu Asn Gln Leu Gly Ala Gln Ala Ala Gly Ala 
            20                  25                  30          


Asn Gln Gly Ser Leu Gly Gly Ile Leu Leu Leu Cys Trp Leu Gly Cys 
        35                  40                  45              


Leu Phe Ile Pro Pro Arg Leu Leu Lys 
    50                  55          


<210> 6688
<211> 199
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<400> 6688
Met Gly Arg Leu His Cys Xaa Glu Asp Pro Val Pro Glu Ala Val Gly 
1               5                   10                  15      


Gly Asp Met Gln Gln Leu Asn Gln Leu Gly Ala Gln Phe Ser Ala Leu 
            20                  25                  30          


Xaa Glu Val Leu Phe His Phe Leu Xaa Glu Pro Lys Glu Val Glu Arg 
        35                  40                  45              


Phe Leu Ala Gln Leu Ser Glu Phe Ala Xaa Xaa Asn Gln Ile Ser Leu 
    50                  55                  60                  


Gly Ser Leu Arg Ser Ile Val Lys Ser Leu Leu Leu Val Pro Asn Gly 
65                  70                  75                  80  


Ala Leu Lys Lys Ser Leu Xaa Ala Lys Gln Val Gln Ala Asp Phe Ile 
                85                  90                  95      


Xaa Leu Gly Leu Ser Glu Glu Lys Ala Xaa Tyr Phe Ser Glu Lys Trp 
            100                 105                 110         


Lys Gln Asn Ala Pro Xaa Leu Ala Arg Trp Ala Ile Gly Gln Xaa Leu 
        115                 120                 125             


Met Ile Asn Gln Leu Ile Asp Met Glu Trp Lys Phe Gly Val Xaa Ser 
    130                 135                 140                 


Gly Ser Ser Glu Leu Glu Lys Val Gly Ser Ile Phe Leu Gln Leu Lys 
145                 150                 155                 160 


Leu Val Val Lys Lys Gly Asn Gln Xaa Glu Asn Val Tyr Ile Glu Leu 
                165                 170                 175     


Xaa Leu Pro Gln Phe Tyr Ser Phe Leu His Glu Met Glu Arg Val Arg 
            180                 185                 190         


Xaa Ser Met Glu Cys Phe Cys 
        195                 


<210> 6689
<211> 157
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<400> 6689
Met Gly Arg Leu His Cys Xaa Glu Asp Pro Val Pro Glu Ala Val Gly 
1               5                   10                  15      


Gly Asp Met Gln Gln Leu Asn Gln Leu Gly Ala Gln Gln Phe Ser Ala 
            20                  25                  30          


Leu Xaa Glu Val Leu Phe His Phe Leu Xaa Glu Pro Lys Glu Ala Arg 
        35                  40                  45              


Val Phe Xaa Val Leu Ser Leu Gln Val Glu Arg Phe Leu Ala Gln Leu 
    50                  55                  60                  


Ser Glu Phe Ala Xaa Xaa Asn Gln Ile Ser Leu Gly Ser Leu Arg Ser 
65                  70                  75                  80  


Ile Val Lys Ser Leu Leu Leu Val Pro Asn Gly Ala Leu Lys Lys Ser 
                85                  90                  95      


Leu Xaa Ala Lys Gln Val Gln Ala Asp Phe Ile Xaa Leu Gly Leu Ser 
            100                 105                 110         


Glu Glu Lys Ala Xaa Tyr Phe Ser Glu Lys Trp Lys Gln Asn Ala Pro 
        115                 120                 125             


Xaa Leu Ala Arg Trp Ala Ile Gly Gln Xaa Leu Met Ile Asn Gln Leu 
    130                 135                 140                 


Ile Asp Met Glu Trp Lys Phe Gly Val Xaa Ser Gly Ser 
145                 150                 155         


<210> 6690
<211> 200
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<400> 6690
Met Gly Arg Leu His Cys Xaa Glu Asp Pro Val Pro Glu Ala Val Gly 
1               5                   10                  15      


Gly Asp Met Gln Gln Leu Asn Gln Leu Gly Ala Gln Gln Phe Ser Ala 
            20                  25                  30          


Leu Xaa Glu Val Leu Phe His Phe Leu Xaa Glu Pro Lys Glu Val Glu 
        35                  40                  45              


Arg Phe Leu Ala Gln Leu Ser Glu Phe Ala Xaa Xaa Asn Gln Ile Ser 
    50                  55                  60                  


Leu Gly Ser Leu Arg Ser Ile Val Lys Ser Leu Leu Leu Val Pro Asn 
65                  70                  75                  80  


Gly Ala Leu Lys Lys Ser Leu Xaa Ala Lys Gln Val Gln Ala Asp Phe 
                85                  90                  95      


Ile Xaa Leu Gly Leu Ser Glu Glu Lys Ala Xaa Tyr Phe Ser Glu Lys 
            100                 105                 110         


Trp Lys Gln Asn Ala Pro Xaa Leu Ala Arg Trp Ala Ile Gly Gln Xaa 
        115                 120                 125             


Leu Met Ile Asn Gln Leu Ile Asp Met Glu Trp Lys Phe Gly Val Xaa 
    130                 135                 140                 


Ser Gly Ser Ser Glu Leu Glu Lys Val Gly Ser Ile Phe Leu Gln Leu 
145                 150                 155                 160 


Lys Leu Val Val Lys Lys Gly Asn Gln Xaa Glu Asn Val Tyr Ile Glu 
                165                 170                 175     


Leu Xaa Leu Pro Gln Phe Tyr Ser Phe Leu His Glu Met Glu Arg Val 
            180                 185                 190         


Arg Xaa Ser Met Glu Cys Phe Cys 
        195                 200 


<210> 6691
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<400> 6691
Lys Xaa Asn His Ser Asn Ile Met Asp Asp Pro Phe Ile Arg Glu His 
1               5                   10                  15      


Ile Glu Glu Leu Leu Arg Asn Ile Arg Xaa Gln Val Leu Ile Lys Leu 
            20                  25                  30          


Ile Lys Pro Tyr Xaa Arg Ile His Ile Pro Phe Ile Ser Lys Met Glu 
        35                  40                  45              


Ser Arg Ser Cys Cys Leu Gly 
    50                  55  


<210> 6692
<211> 263
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<400> 6692
Met Ser Asp Met Glu Asp Asp Phe Met Cys Asp Asp Glu Glu Asp Tyr 
1               5                   10                  15      


Asp Leu Glu Tyr Ser Glu Asp Ser Asn Ser Glu Pro Asn Val Asp Leu 
            20                  25                  30          


Glu Asn Gln Tyr Tyr Asn Ser Lys Ala Leu Lys Glu Asp Asp Pro Lys 
        35                  40                  45              


Ala Ala Leu Ser Ser Phe Gln Lys Val Leu Glu Leu Glu Gly Glu Lys 
    50                  55                  60                  


Gly Glu Trp Gly Phe Lys Ala Leu Lys Gln Met Ile Lys Ile Asn Phe 
65                  70                  75                  80  


Lys Leu Xaa Asn Phe Pro Glu Met Met Asn Arg Tyr Lys Gln Leu Leu 
                85                  90                  95      


Xaa Tyr Ile Arg Ser Ala Val Xaa Arg Asn Tyr Ser Glu Lys Ser Ile 
            100                 105                 110         


Asn Ser Ile Leu Asp Tyr Ile Ser Xaa Ser Lys Gln Met Asp Leu Leu 
        115                 120                 125             


Gln Glu Phe Tyr Glu Xaa Xaa Leu Glu Ala Leu Lys Asp Ala Lys Asn 
    130                 135                 140                 


Asp Arg Leu Trp Phe Lys Xaa Asn Xaa Lys Leu Gly Lys Leu Tyr Leu 
145                 150                 155                 160 


Glu Arg Glu Glu Tyr Gly Lys Leu Gln Lys Ile Leu Arg Gln Leu His 
                165                 170                 175     


Gln Ser Cys Gln Xaa Asp Asp Gly Glu Asp Asp Leu Lys Lys Gly Xaa 
            180                 185                 190         


Gln Leu Leu Glu Ile Tyr Ala Leu Glu Ile Gln Met Tyr Xaa Ala Gln 
        195                 200                 205             


Lys Asn Asn Lys Lys Leu Lys Ala Leu Tyr Glu Gln Ser Leu His Ile 
    210                 215                 220                 


Lys Ser Ala Ile Pro His Pro Leu Ile Met Gly Val Ile Arg Glu Cys 
225                 230                 235                 240 


Gly Gly Lys Met His Leu Arg Glu Gly Glu Phe Glu Lys Ala His Xaa 
                245                 250                 255     


Asp Phe Phe Glu Ala Phe Lys 
            260             


<210> 6693
<211> 443
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<400> 6693
Met Ser Asp Met Glu Asp Asp Phe Met Cys Asp Asp Glu Glu Asp Tyr 
1               5                   10                  15      


Asp Leu Glu Tyr Ser Glu Asp Ser Asn Ser Glu Pro Asn Val Asp Leu 
            20                  25                  30          


Glu Asn Gln Tyr Tyr Asn Ser Lys Ala Leu Lys Glu Asp Asp Pro Lys 
        35                  40                  45              


Ala Ala Leu Ser Ser Phe Gln Lys Val Leu Glu Leu Glu Gly Glu Lys 
    50                  55                  60                  


Gly Glu Trp Gly Phe Lys Ala Leu Lys Gln Met Ile Lys Ile Asn Phe 
65                  70                  75                  80  


Lys Leu Xaa Asn Phe Pro Glu Met Met Asn Arg Tyr Lys Gln Leu Leu 
                85                  90                  95      


Xaa Tyr Ile Arg Ser Ala Val Xaa Arg Asn Tyr Ser Glu Lys Ser Ile 
            100                 105                 110         


Asn Ser Ile Leu Asp Tyr Ile Ser Xaa Ser Lys Gln Met Asp Leu Leu 
        115                 120                 125             


Gln Glu Phe Tyr Glu Xaa Xaa Leu Glu Ala Leu Lys Asp Ala Lys Asn 
    130                 135                 140                 


Asp Arg Leu Trp Phe Lys Xaa Asn Xaa Lys Leu Gly Lys Leu Tyr Leu 
145                 150                 155                 160 


Glu Arg Glu Glu Tyr Gly Lys Leu Gln Lys Ile Leu Arg Gln Leu His 
                165                 170                 175     


Gln Ser Cys Gln Xaa Asp Asp Gly Glu Asp Asp Leu Lys Lys Gly Xaa 
            180                 185                 190         


Gln Leu Leu Glu Ile Tyr Ala Leu Glu Ile Gln Met Tyr Xaa Ala Gln 
        195                 200                 205             


Lys Asn Asn Lys Lys Leu Lys Ala Leu Tyr Glu Gln Ser Leu His Ile 
    210                 215                 220                 


Lys Ser Ala Ile Pro His Pro Leu Ile Met Gly Val Ile Arg Glu Cys 
225                 230                 235                 240 


Gly Gly Lys Met His Leu Arg Glu Gly Glu Phe Glu Lys Ala His Xaa 
                245                 250                 255     


Asp Phe Phe Glu Ala Phe Lys Asn Tyr Asp Glu Ser Gly Ser Pro Arg 
            260                 265                 270         


Arg Xaa Xaa Cys Leu Lys Tyr Leu Val Leu Ala Asn Met Leu Met Lys 
        275                 280                 285             


Ser Gly Ile Asn Pro Phe Asp Ser Gln Glu Ala Lys Pro Tyr Lys Asn 
    290                 295                 300                 


Asp Pro Glu Ile Leu Ala Met Xaa Asn Leu Val Ser Ala Tyr Gln Asn 
305                 310                 315                 320 


Asn Asp Ile Xaa Glu Phe Glu Lys Ile Leu Lys Xaa Asn His Ser Asn 
                325                 330                 335     


Ile Met Asp Asp Pro Phe Ile Arg Glu His Ile Glu Glu Leu Leu Arg 
            340                 345                 350         


Asn Ile Arg Xaa Gln Val Leu Ile Lys Leu Ile Lys Pro Tyr Xaa Arg 
        355                 360                 365             


Ile His Ile Pro Phe Ile Ser Lys Glu Leu Asn Ile Asp Val Ala Asp 
    370                 375                 380                 


Val Glu Ser Leu Leu Val Gln Cys Ile Leu Asp Asn Xaa Ile His Gly 
385                 390                 395                 400 


Arg Ile Asp Gln Val Asn Gln Leu Leu Glu Leu Asp His Gln Lys Arg 
                405                 410                 415     


Gly Gly Ala Arg Tyr Xaa Ala Leu Asp Lys Trp Xaa Asn Gln Leu Asn 
            420                 425                 430         


Ser Leu Asn Gln Ala Val Val Ser Lys Leu Ala 
        435                 440             


<210> 6694
<211> 450
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<400> 6694
Met Ser Asp Met Glu Asp Asp Phe Met Cys Asp Asp Glu Glu Asp Tyr 
1               5                   10                  15      


Asp Leu Glu Tyr Ser Glu Asp Ser Asn Ser Glu Pro Asn Val Asp Leu 
            20                  25                  30          


Glu Asn Gln Tyr Tyr Asn Ser Lys Ala Leu Lys Glu Asp Asp Pro Lys 
        35                  40                  45              


Ala Ala Leu Ser Ser Phe Gln Lys Val Leu Glu Leu Glu Gly Glu Lys 
    50                  55                  60                  


Gly Glu Trp Gly Phe Lys Ala Leu Lys Gln Met Ile Lys Ile Asn Phe 
65                  70                  75                  80  


Lys Leu Xaa Asn Phe Pro Glu Met Met Asn Arg Tyr Lys Gln Leu Leu 
                85                  90                  95      


Xaa Tyr Ile Arg Ser Ala Val Xaa Arg Asn Tyr Ser Glu Lys Ser Ile 
            100                 105                 110         


Asn Ser Ile Leu Asp Tyr Ile Ser Xaa Ser Lys Gln Asn Ser Asp Phe 
        115                 120                 125             


Leu Cys Gln Met Asp Leu Leu Gln Glu Phe Tyr Glu Xaa Xaa Leu Glu 
    130                 135                 140                 


Ala Leu Lys Asp Ala Lys Asn Asp Arg Leu Trp Phe Lys Xaa Asn Xaa 
145                 150                 155                 160 


Lys Leu Gly Lys Leu Tyr Leu Glu Arg Glu Glu Tyr Gly Lys Leu Gln 
                165                 170                 175     


Lys Ile Leu Arg Gln Leu His Gln Ser Cys Gln Xaa Asp Asp Gly Glu 
            180                 185                 190         


Asp Asp Leu Lys Lys Gly Xaa Gln Leu Leu Glu Ile Tyr Ala Leu Glu 
        195                 200                 205             


Ile Gln Met Tyr Xaa Ala Gln Lys Asn Asn Lys Lys Leu Lys Ala Leu 
    210                 215                 220                 


Tyr Glu Gln Ser Leu His Ile Lys Ser Ala Ile Pro His Pro Leu Ile 
225                 230                 235                 240 


Met Gly Val Ile Arg Glu Cys Gly Gly Lys Met His Leu Arg Glu Gly 
                245                 250                 255     


Glu Phe Glu Lys Ala His Xaa Asp Phe Phe Glu Ala Phe Lys Asn Tyr 
            260                 265                 270         


Asp Glu Ser Gly Ser Pro Arg Arg Xaa Xaa Cys Leu Lys Tyr Leu Val 
        275                 280                 285             


Leu Ala Asn Met Leu Met Lys Ser Gly Ile Asn Pro Phe Asp Ser Gln 
    290                 295                 300                 


Glu Ala Lys Pro Tyr Lys Asn Asp Pro Glu Ile Leu Ala Met Xaa Asn 
305                 310                 315                 320 


Leu Val Ser Ala Tyr Gln Asn Asn Asp Ile Xaa Glu Phe Glu Lys Ile 
                325                 330                 335     


Leu Lys Xaa Asn His Ser Asn Ile Met Asp Asp Pro Phe Ile Arg Glu 
            340                 345                 350         


His Ile Glu Glu Leu Leu Arg Asn Ile Arg Xaa Gln Val Leu Ile Lys 
        355                 360                 365             


Leu Ile Lys Pro Tyr Xaa Arg Ile His Ile Pro Phe Ile Ser Lys Glu 
    370                 375                 380                 


Leu Asn Ile Asp Val Ala Asp Val Glu Ser Leu Leu Val Gln Cys Ile 
385                 390                 395                 400 


Leu Asp Asn Xaa Ile His Gly Arg Ile Asp Gln Val Asn Gln Leu Leu 
                405                 410                 415     


Glu Leu Asp His Gln Lys Arg Gly Gly Ala Arg Tyr Xaa Ala Leu Asp 
            420                 425                 430         


Lys Trp Xaa Asn Gln Leu Asn Ser Leu Asn Gln Ala Val Val Ser Lys 
        435                 440                 445             


Leu Ala 
    450 


<210> 6695
<211> 183
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<400> 6695
Met Ser Asp Met Glu Asp Asp Phe Met Cys Asp Asp Glu Glu Asp Tyr 
1               5                   10                  15      


Asp Leu Xaa Asn Phe Pro Glu Met Met Asn Arg Tyr Lys Gln Leu Leu 
            20                  25                  30          


Xaa Tyr Ile Arg Ser Ala Val Xaa Arg Asn Tyr Ser Glu Lys Ser Ile 
        35                  40                  45              


Asn Ser Ile Leu Asp Tyr Ile Ser Xaa Ser Lys Gln Met Asp Leu Leu 
    50                  55                  60                  


Gln Glu Phe Tyr Glu Xaa Xaa Leu Glu Ala Leu Lys Asp Ala Lys Asn 
65                  70                  75                  80  


Asp Arg Leu Trp Phe Lys Xaa Asn Xaa Lys Leu Gly Lys Leu Tyr Leu 
                85                  90                  95      


Glu Arg Glu Glu Tyr Gly Lys Leu Gln Lys Ile Leu Arg Gln Leu His 
            100                 105                 110         


Gln Ser Cys Gln Xaa Asp Asp Gly Glu Asp Asp Leu Lys Lys Gly Xaa 
        115                 120                 125             


Gln Leu Leu Glu Ile Tyr Ala Leu Glu Ile Gln Met Tyr Xaa Ala Gln 
    130                 135                 140                 


Lys Asn Asn Lys Lys Leu Lys Ala Leu Tyr Glu Gln Ser Leu His Ile 
145                 150                 155                 160 


Lys Ser Ala Ile Pro His Pro Leu Ile Met Gly Val Ile Arg Glu Cys 
                165                 170                 175     


Gly Gly Lys Met His Leu Arg 
            180             


<210> 6696
<211> 379
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<400> 6696
Met Ser Asp Met Glu Asp Asp Phe Met Cys Asp Asp Glu Glu Asp Tyr 
1               5                   10                  15      


Asp Leu Xaa Asn Phe Pro Glu Met Met Asn Arg Tyr Lys Gln Leu Leu 
            20                  25                  30          


Xaa Tyr Ile Arg Ser Ala Val Xaa Arg Asn Tyr Ser Glu Lys Ser Ile 
        35                  40                  45              


Asn Ser Ile Leu Asp Tyr Ile Ser Xaa Ser Lys Gln Met Asp Leu Leu 
    50                  55                  60                  


Gln Glu Phe Tyr Glu Xaa Xaa Leu Glu Ala Leu Lys Asp Ala Lys Asn 
65                  70                  75                  80  


Asp Arg Leu Trp Phe Lys Xaa Asn Xaa Lys Leu Gly Lys Leu Tyr Leu 
                85                  90                  95      


Glu Arg Glu Glu Tyr Gly Lys Leu Gln Lys Ile Leu Arg Gln Leu His 
            100                 105                 110         


Gln Ser Cys Gln Xaa Asp Asp Gly Glu Asp Asp Leu Lys Lys Gly Xaa 
        115                 120                 125             


Gln Leu Leu Glu Ile Tyr Ala Leu Glu Ile Gln Met Tyr Xaa Ala Gln 
    130                 135                 140                 


Lys Asn Asn Lys Lys Leu Lys Ala Leu Tyr Glu Gln Ser Leu His Ile 
145                 150                 155                 160 


Lys Ser Ala Ile Pro His Pro Leu Ile Met Gly Val Ile Arg Glu Cys 
                165                 170                 175     


Gly Gly Lys Met His Leu Arg Glu Gly Glu Phe Glu Lys Ala His Xaa 
            180                 185                 190         


Asp Phe Phe Glu Ala Phe Lys Asn Tyr Asp Glu Ser Gly Ser Pro Arg 
        195                 200                 205             


Arg Xaa Xaa Cys Leu Lys Tyr Leu Val Leu Ala Asn Met Leu Met Lys 
    210                 215                 220                 


Ser Gly Ile Asn Pro Phe Asp Ser Gln Glu Ala Lys Pro Tyr Lys Asn 
225                 230                 235                 240 


Asp Pro Glu Ile Leu Ala Met Xaa Asn Leu Val Ser Ala Tyr Gln Asn 
                245                 250                 255     


Asn Asp Ile Xaa Glu Phe Glu Lys Ile Leu Lys Xaa Asn His Ser Asn 
            260                 265                 270         


Ile Met Asp Asp Pro Phe Ile Arg Glu His Ile Glu Glu Leu Leu Arg 
        275                 280                 285             


Asn Ile Arg Xaa Gln Val Leu Ile Lys Leu Ile Lys Pro Tyr Xaa Arg 
    290                 295                 300                 


Ile His Ile Pro Phe Ile Ser Lys Glu Leu Asn Ile Asp Val Ala Asp 
305                 310                 315                 320 


Val Glu Ser Leu Leu Val Gln Cys Ile Leu Asp Asn Xaa Ile His Gly 
                325                 330                 335     


Arg Ile Asp Gln Val Asn Gln Leu Leu Glu Leu Asp His Gln Lys Arg 
            340                 345                 350         


Gly Gly Ala Arg Tyr Xaa Ala Leu Asp Lys Trp Xaa Asn Gln Leu Asn 
        355                 360                 365             


Ser Leu Asn Gln Ala Val Val Ser Lys Leu Ala 
    370                 375                 


<210> 6697
<211> 51
<212> PRT
<213> Homo sapiens

<400> 6697
Glu Ile Phe Ala Ser Ile Asn Gln Lys Asp Gly Met Val Ser Phe His 
1               5                   10                  15      


Asp Asn Pro Glu Lys Tyr Asn Asn Pro Ala Met Leu His Asn Ile Asp 
            20                  25                  30          


Gln Glu Ser Met Gly Ser Gln Glu Asp Asp Ser Gly Asn Lys Pro Ser 
        35                  40                  45              


Ser Tyr Ser 
    50      


<210> 6698
<211> 20
<212> PRT
<213> Homo sapiens

<400> 6698
Met Ala Ser Ala Leu Glu Gln Phe Val Asn Ser Val Arg Gln Leu Ser 
1               5                   10                  15      


Ala Gln Gly Leu 
            20  


<210> 6699
<211> 116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<400> 6699
Met Ala Ser Ala Leu Glu Gln Phe Val Asn Ser Val Arg Gln Leu Ser 
1               5                   10                  15      


Ala Gln Gly Gln Met Xaa Gln Leu Cys Glu Leu Ile Asn Lys Ser Gly 
            20                  25                  30          


Glu Leu Leu Ala Lys Asn Leu Ser His Leu Asp Xaa Val Leu Gly Ala 
        35                  40                  45              


Leu Asp Val Gln Glu His Ser Leu Gly Val Leu Ala Val Leu Phe Val 
    50                  55                  60                  


Lys Phe Ser Met Pro Ser Val Pro Asp Phe Glu Xaa Leu Phe Ser Gln 
65                  70                  75                  80  


Val Gln Leu Phe Ile Ser Xaa Cys Asn Gly Glu His Ile Arg Tyr Ala 
                85                  90                  95      


Xaa Asp Xaa Phe Ala Gly Leu Cys His Gln Leu Xaa Asn Ala Leu Val 
            100                 105                 110         


Glu Arg Lys Gln 
        115     


<210> 6700
<211> 423
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<400> 6700
Met Ala Ser Ala Leu Glu Gln Phe Val Asn Ser Val Arg Gln Leu Ser 
1               5                   10                  15      


Ala Gln Gly Gln Met Xaa Gln Leu Cys Glu Leu Ile Asn Lys Ser Gly 
            20                  25                  30          


Glu Leu Leu Ala Lys Asn Leu Ser His Leu Asp Xaa Val Leu Gly Ala 
        35                  40                  45              


Leu Asp Val Gln Glu His Ser Leu Gly Val Leu Ala Val Leu Phe Val 
    50                  55                  60                  


Lys Phe Ser Met Pro Ser Val Pro Asp Phe Glu Xaa Leu Phe Ser Gln 
65                  70                  75                  80  


Val Gln Leu Phe Ile Ser Xaa Cys Asn Gly Glu His Ile Arg Tyr Ala 
                85                  90                  95      


Xaa Asp Xaa Phe Ala Gly Leu Cys His Gln Leu Xaa Asn Ala Leu Val 
            100                 105                 110         


Glu Arg Lys Gln Pro Leu Arg Gly Ile Gly Ile Leu Lys Gln Ala Ile 
        115                 120                 125             


Asp Lys Met Gln Met Asn Xaa Asn Gln Leu Xaa Ser Ile His Ala Asp 
    130                 135                 140                 


Leu Cys Gln Leu Cys Leu Leu Ala Lys Cys Phe Lys Pro Ala Leu Pro 
145                 150                 155                 160 


Tyr Leu Asp Val Asp Met Met Asp Ile Cys Lys Glu Asn Gly Ala Tyr 
                165                 170                 175     


Asp Ala Lys His Phe Leu Cys Tyr Tyr Tyr Tyr Gly Gly Met Ile Tyr 
            180                 185                 190         


Xaa Gly Leu Lys Asn Phe Glu Arg Ala Leu Tyr Phe Tyr Glu Gln Ala 
        195                 200                 205             


Ile Xaa Xaa Pro Ala Met Ala Val Ser His Ile Met Leu Glu Ser Tyr 
    210                 215                 220                 


Lys Lys Tyr Ile Leu Val Ser Leu Ile Leu Leu Gly Lys Val Gln Gln 
225                 230                 235                 240 


Leu Pro Lys Tyr Xaa Ser Gln Ile Val Gly Arg Phe Ile Lys Pro Leu 
                245                 250                 255     


Ser Asn Ala Tyr His Glu Leu Ala Gln Val Tyr Ser Xaa Asn Asn Pro 
            260                 265                 270         


Ser Glu Leu Arg Asn Leu Val Asn Lys His Ser Glu Xaa Phe Xaa Arg 
        275                 280                 285             


Asp Asn Asn Met Gly Leu Val Lys Gln Cys Leu Ser Ser Leu Tyr Lys 
    290                 295                 300                 


Lys Asn Ile Gln Arg Leu Xaa Lys Xaa Phe Leu Xaa Leu Ser Leu Gln 
305                 310                 315                 320 


Asp Met Ala Ser Arg Val Gln Leu Ser Gly Pro Gln Glu Ala Glu Lys 
                325                 330                 335     


Tyr Val Leu His Met Ile Glu Asp Gly Glu Ile Phe Ala Ser Ile Asn 
            340                 345                 350         


Gln Lys Asp Gly Met Val Ser Phe His Asp Asn Pro Glu Lys Tyr Asn 
        355                 360                 365             


Asn Pro Ala Met Leu His Asn Ile Asp Gln Glu Met Leu Lys Cys Ile 
    370                 375                 380                 


Glu Leu Asp Glu Arg Leu Lys Ala Met Asp Gln Glu Ile Xaa Val Asn 
385                 390                 395                 400 


Pro Gln Phe Val Gln Lys Ser Met Gly Ser Gln Glu Asp Asp Ser Gly 
                405                 410                 415     


Asn Lys Pro Ser Ser Tyr Ser 
            420             


<210> 6701
<211> 319
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<400> 6701
Met Ala Ser Ala Leu Glu Gln Phe Val Asn Ser Val Arg Gln Leu Ser 
1               5                   10                  15      


Ala Gln Gly Gln Met Xaa Gln Leu Cys Glu Leu Ile Asn Lys Ser Gly 
            20                  25                  30          


Glu Leu Leu Ala Lys Asn Leu Ser His Leu Asp Xaa Val Leu Gly Ala 
        35                  40                  45              


Leu Asp Val Gln Glu His Ser Leu Gly Val Leu Ala Val Leu Phe Val 
    50                  55                  60                  


Lys Phe Ser Met Pro Ser Val Pro Asp Phe Glu Xaa Leu Phe Ser Gln 
65                  70                  75                  80  


Val Gln Leu Phe Ile Ser Xaa Cys Asn Gly Glu His Ile Arg Tyr Ala 
                85                  90                  95      


Xaa Asp Xaa Phe Ala Gly Leu Cys His Gln Leu Xaa Asn Ala Leu Val 
            100                 105                 110         


Glu Arg Lys Gln Pro Leu Arg Gly Ile Gly Ile Leu Lys Gln Ala Ile 
        115                 120                 125             


Asp Lys Met Gln Met Asn Xaa Asn Gln Leu Xaa Ser Ile His Ala Asp 
    130                 135                 140                 


Leu Cys Gln Leu Cys Leu Leu Ala Lys Cys Phe Lys Pro Ala Leu Pro 
145                 150                 155                 160 


Tyr Leu Asp Val Asp Met Met Asp Ile Cys Lys Glu Asn Gly Ala Tyr 
                165                 170                 175     


Asp Ala Lys His Phe Leu Cys Tyr Tyr Tyr Tyr Gly Gly Met Ile Tyr 
            180                 185                 190         


Xaa Gly Leu Lys Asn Phe Glu Arg Ala Leu Tyr Phe Tyr Glu Gln Ala 
        195                 200                 205             


Ile Xaa Xaa Pro Ala Met Ala Val Ser His Ile Met Leu Glu Ser Tyr 
    210                 215                 220                 


Lys Lys Tyr Ile Leu Val Ser Leu Ile Leu Leu Gly Lys Val Gln Gln 
225                 230                 235                 240 


Leu Pro Lys Tyr Xaa Ser Gln Ile Val Gly Arg Phe Ile Lys Arg Gln 
                245                 250                 255     


Ser Leu Ala Met Leu Ala Arg Leu Val Leu Asn Ser Trp Pro Gln Ala 
            260                 265                 270         


Val Leu Leu Arg Leu Pro Pro Arg Val Leu Gly Leu Gln Pro Leu Ser 
        275                 280                 285             


Asn Ala Tyr His Glu Leu Ala Gln Val Tyr Ser Xaa Asn Asn Pro Ser 
    290                 295                 300                 


Glu Leu Arg Asn Leu Val Asn Lys His Ser Glu Xaa Phe Xaa Arg 
305                 310                 315                 


<210> 6702
<211> 107
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<400> 6702
Met Ala Ser Ala Leu Glu Gln Phe Val Asn Ser Val Arg Gln Leu Ser 
1               5                   10                  15      


Ala Gln Gly Gln Met Xaa Gln Leu Cys Glu Leu Ile Asn Lys Ser Gly 
            20                  25                  30          


Glu Leu Leu Ala Lys Asn Leu Ser His Leu Asp Xaa Val Leu Gly Ala 
        35                  40                  45              


Leu Asp Val Gln Glu His Ser Leu Gly Val Leu Ala Val Leu Phe Val 
    50                  55                  60                  


Lys Phe Ser Met Pro Ser Val Pro Asp Phe Glu Xaa Leu Phe Ser Gln 
65                  70                  75                  80  


Val Gln Leu Phe Ile Ser Xaa Cys Asn Gly Glu His Ile Arg Tyr Ala 
                85                  90                  95      


Xaa Asp Xaa Ser Pro Ala Arg Asn Trp His Pro 
            100                 105         


<210> 6703
<211> 31
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<400> 6703
Met Ala Ser Ala Leu Glu Gln Phe Val Asn Ser Val Arg Gln Leu Ser 
1               5                   10                  15      


Ala Gln Val Leu Phe Leu Phe Ser Arg Ala Asn Asp Xaa Ala Leu 
            20                  25                  30      


<210> 6704
<211> 403
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<400> 6704
Met Xaa Gln Leu Cys Glu Leu Ile Asn Lys Ser Gly Glu Leu Leu Ala 
1               5                   10                  15      


Lys Asn Leu Ser His Leu Asp Xaa Val Leu Gly Ala Leu Asp Val Gln 
            20                  25                  30          


Glu His Ser Leu Gly Val Leu Ala Val Leu Phe Val Lys Phe Ser Met 
        35                  40                  45              


Pro Ser Val Pro Asp Phe Glu Xaa Leu Phe Ser Gln Val Gln Leu Phe 
    50                  55                  60                  


Ile Ser Xaa Cys Asn Gly Glu His Ile Arg Tyr Ala Xaa Asp Xaa Phe 
65                  70                  75                  80  


Ala Gly Leu Cys His Gln Leu Xaa Asn Ala Leu Val Glu Arg Lys Gln 
                85                  90                  95      


Pro Leu Arg Gly Ile Gly Ile Leu Lys Gln Ala Ile Asp Lys Met Gln 
            100                 105                 110         


Met Asn Xaa Asn Gln Leu Xaa Ser Ile His Ala Asp Leu Cys Gln Leu 
        115                 120                 125             


Cys Leu Leu Ala Lys Cys Phe Lys Pro Ala Leu Pro Tyr Leu Asp Val 
    130                 135                 140                 


Asp Met Met Asp Ile Cys Lys Glu Asn Gly Ala Tyr Asp Ala Lys His 
145                 150                 155                 160 


Phe Leu Cys Tyr Tyr Tyr Tyr Gly Gly Met Ile Tyr Xaa Gly Leu Lys 
                165                 170                 175     


Asn Phe Glu Arg Ala Leu Tyr Phe Tyr Glu Gln Ala Ile Xaa Xaa Pro 
            180                 185                 190         


Ala Met Ala Val Ser His Ile Met Leu Glu Ser Tyr Lys Lys Tyr Ile 
        195                 200                 205             


Leu Val Ser Leu Ile Leu Leu Gly Lys Val Gln Gln Leu Pro Lys Tyr 
    210                 215                 220                 


Xaa Ser Gln Ile Val Gly Arg Phe Ile Lys Pro Leu Ser Asn Ala Tyr 
225                 230                 235                 240 


His Glu Leu Ala Gln Val Tyr Ser Xaa Asn Asn Pro Ser Glu Leu Arg 
                245                 250                 255     


Asn Leu Val Asn Lys His Ser Glu Xaa Phe Xaa Arg Asp Asn Asn Met 
            260                 265                 270         


Gly Leu Val Lys Gln Cys Leu Ser Ser Leu Tyr Lys Lys Asn Ile Gln 
        275                 280                 285             


Arg Leu Xaa Lys Xaa Phe Leu Xaa Leu Ser Leu Gln Asp Met Ala Ser 
    290                 295                 300                 


Arg Val Gln Leu Ser Gly Pro Gln Glu Ala Glu Lys Tyr Val Leu His 
305                 310                 315                 320 


Met Ile Glu Asp Gly Glu Ile Phe Ala Ser Ile Asn Gln Lys Asp Gly 
                325                 330                 335     


Met Val Ser Phe His Asp Asn Pro Glu Lys Tyr Asn Asn Pro Ala Met 
            340                 345                 350         


Leu His Asn Ile Asp Gln Glu Met Leu Lys Cys Ile Glu Leu Asp Glu 
        355                 360                 365             


Arg Leu Lys Ala Met Asp Gln Glu Ile Xaa Val Asn Pro Gln Phe Val 
    370                 375                 380                 


Gln Lys Ser Met Gly Ser Gln Glu Asp Asp Ser Gly Asn Lys Pro Ser 
385                 390                 395                 400 


Ser Tyr Ser 
            


<210> 6705
<211> 345
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<400> 6705
Met Xaa Gln Leu Cys Glu Leu Ile Asn Lys Ser Gly Glu Leu Leu Ala 
1               5                   10                  15      


Lys Asn Leu Ser His Leu Asp Xaa Val Leu Gly Ala Leu Asp Val Gln 
            20                  25                  30          


Glu His Ser Leu Gly Val Leu Ala Val Leu Phe Val Lys Phe Ser Met 
        35                  40                  45              


Pro Ser Val Pro Asp Phe Glu Xaa Leu Phe Ser Gln Val Gln Leu Phe 
    50                  55                  60                  


Ile Ser Xaa Cys Asn Gly Glu His Ile Arg Tyr Ala Xaa Asp Xaa Phe 
65                  70                  75                  80  


Ala Gly Leu Cys His Gln Leu Xaa Asn Ala Leu Val Glu Arg Lys Gln 
                85                  90                  95      


Pro Leu Arg Gly Ile Gly Ile Leu Lys Gln Ala Ile Asp Lys Met Gln 
            100                 105                 110         


Met Asn Xaa Asn Gln Leu Xaa Ser Ile His Ala Asp Leu Cys Gln Leu 
        115                 120                 125             


Cys Leu Leu Ala Lys Cys Phe Lys Pro Ala Leu Pro Tyr Leu Asp Val 
    130                 135                 140                 


Asp Met Met Asp Ile Cys Lys Glu Asn Gly Ala Tyr Asp Ala Lys His 
145                 150                 155                 160 


Phe Leu Cys Tyr Tyr Tyr Tyr Gly Gly Met Ile Tyr Xaa Gly Leu Lys 
                165                 170                 175     


Asn Phe Glu Arg Ala Leu Tyr Phe Tyr Glu Gln Ala Ile Xaa Xaa Pro 
            180                 185                 190         


Ala Met Ala Val Ser His Ile Met Leu Glu Ser Tyr Lys Lys Tyr Ile 
        195                 200                 205             


Leu Val Ser Leu Ile Leu Leu Gly Lys Val Gln Gln Leu Pro Lys Tyr 
    210                 215                 220                 


Xaa Ser Gln Ile Val Gly Arg Phe Ile Lys Xaa Phe Leu Xaa Leu Ser 
225                 230                 235                 240 


Leu Gln Asp Met Ala Ser Arg Val Gln Leu Ser Gly Pro Gln Glu Ala 
                245                 250                 255     


Glu Lys Tyr Val Leu His Met Ile Glu Asp Gly Glu Ile Phe Ala Ser 
            260                 265                 270         


Ile Asn Gln Lys Asp Gly Met Val Ser Phe His Asp Asn Pro Glu Lys 
        275                 280                 285             


Tyr Asn Asn Pro Ala Met Leu His Asn Ile Asp Gln Glu Met Leu Lys 
    290                 295                 300                 


Cys Ile Glu Leu Asp Glu Arg Leu Lys Ala Met Asp Gln Glu Ile Xaa 
305                 310                 315                 320 


Val Asn Pro Gln Phe Val Gln Lys Ser Met Gly Ser Gln Glu Asp Asp 
                325                 330                 335     


Ser Gly Asn Lys Pro Ser Ser Tyr Ser 
            340                 345 


<210> 6706
<211> 17
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<400> 6706
Xaa Ala Gly Leu Cys His Gln Leu Xaa Asn Ala Leu Val Glu Arg Lys 
1               5                   10                  15      


Gln 
    


<210> 6707
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<400> 6707
Xaa Phe Glu Xaa Leu Phe Ser Gln Val Gln Leu Phe Ile Ser Xaa Cys 
1               5                   10                  15      


Asn Gly Glu His Ile Arg Tyr Ala Xaa Asp Xaa Phe Ala Gly Leu Cys 
            20                  25                  30          


His Gln Leu Xaa Asn Ala Leu Val Glu Arg Lys Gln Pro Leu Arg Gly 
        35                  40                  45              


Ile Gly Ile Leu Lys Gln Ala Ile Asp Lys Met Gln Met Asn Xaa Asn 
    50                  55                  60                  


Gln Leu Xaa Ser Ile His Ala Asp Leu Cys Gln Ala Ile Xaa Xaa Pro 
65                  70                  75                  80  


Ala Met Ala Val Ser His Ile Met Leu Glu Ser Tyr Lys Lys Tyr Ile 
                85                  90                  95      


Leu Val Ser Leu Ile Leu Leu Gly Lys Val Gln Gln Leu Pro Lys Tyr 
            100                 105                 110         


Xaa Ser Gln Ile Val Gly Arg Phe Ile Lys 
        115                 120         


<210> 6708
<211> 275
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<400> 6708
Met Ala Ala Ala Val Arg Gln Asp Leu Ala Gln Leu Met Asn Ser Ser 
1               5                   10                  15      


Gly Ser His Lys Asp Leu Ala Gly Lys Gln Tyr Asn Val Asp Tyr Lys 
            20                  25                  30          


Leu Glu Xaa Tyr Leu Lys Ile Ala Arg Leu Tyr Leu Glu Asp Asp Asp 
        35                  40                  45              


Pro Val Gln Ala Glu Ala Tyr Ile Asn Arg Ala Ser Leu Leu Gln Asn 
    50                  55                  60                  


Glu Ser Xaa Asn Glu Gln Leu Gln Ile His Tyr Lys Val Cys Tyr Ala 
65                  70                  75                  80  


Arg Val Leu Asp Tyr Arg Arg Lys Phe Ile Glu Ala Ala Gln Arg Tyr 
                85                  90                  95      


Asn Glu Leu Ser Tyr Lys Xaa Ile Val His Glu Ser Glu Arg Leu Glu 
            100                 105                 110         


Ala Leu Lys His Ala Leu His Cys Xaa Ile Leu Ala Ser Ala Gly Gln 
        115                 120                 125             


Gln Arg Ser Arg Met Leu Ala Xaa Leu Phe Lys Asp Glu Arg Cys Gln 
    130                 135                 140                 


Gln Leu Ala Ala Tyr Gly Ile Leu Glu Lys Met Tyr Leu Asp Arg Ile 
145                 150                 155                 160 


Ile Arg Gly Asn Gln Leu Gln Glu Phe Ala Ala Met Leu Met Pro His 
                165                 170                 175     


Gln Lys Ala Xaa Xaa Ala Asp Gly Ser Ser Ile Leu Asp Arg Ala Val 
            180                 185                 190         


Ile Glu His Asn Leu Leu Ser Ala Ser Lys Leu Tyr Asn Asn Ile Xaa 
        195                 200                 205             


Phe Glu Glu Leu Gly Ala Leu Leu Glu Ile Pro Ala Ala Lys Ala Glu 
    210                 215                 220                 


Lys Ile Ala Ser Gln Met Ile Xaa Glu Gly Arg Met Asn Gly Phe Ile 
225                 230                 235                 240 


Asp Gln Ile Asp Gly Ile Val His Phe Glu Xaa Arg Glu Ala Leu Pro 
                245                 250                 255     


Xaa Trp Asp Lys Gln Ile Gln Ser Leu Cys Phe Gln Val Asn Asn Leu 
            260                 265                 270         


Leu Glu Lys 
        275 


<210> 6709
<211> 51
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<400> 6709
Met Ala Ala Ala Val Arg Gln Asp Leu Ala Gln Leu Met Asn Ser Ser 
1               5                   10                  15      


Gly Ser His Lys Asp Leu Ala Gly Lys Xaa Leu Phe Ser Phe Gly Ile 
            20                  25                  30          


Val Val Gly Ile Val Arg Ser Trp Lys Lys Pro Phe Ser Tyr Leu Glu 
        35                  40                  45              


Gln Asn Asn 
    50      


<210> 6710
<211> 352
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<400> 6710
Met Ala Ala Ala Val Arg Gln Asp Leu Ala Gln Leu Met Asn Ser Ser 
1               5                   10                  15      


Gly Ser His Lys Asp Leu Ala Gly Lys Tyr Arg Gln Ile Leu Glu Lys 
            20                  25                  30          


Ala Ile Gln Leu Ser Gly Ala Glu Gln Leu Glu Ala Leu Lys Ala Phe 
        35                  40                  45              


Val Glu Ala Met Val Asn Glu Asn Val Ser Leu Val Ile Ser Arg Gln 
    50                  55                  60                  


Leu Leu Xaa Asp Phe Cys Xaa His Leu Pro Asn Leu Pro Asp Ser Xaa 
65                  70                  75                  80  


Ala Lys Glu Ile Tyr His Phe Xaa Leu Glu Lys Ile Gln Pro Arg Val 
                85                  90                  95      


Ile Ser Phe Glu Glu Gln Val Ala Ser Ile Arg Gln His Leu Ala Ser 
            100                 105                 110         


Ile Tyr Glu Lys Glu Glu Asp Trp Arg Asn Ala Ala Gln Val Leu Val 
        115                 120                 125             


Gly Ile Pro Leu Glu Xaa Gly Gln Lys Gln Tyr Asn Val Asp Tyr Lys 
    130                 135                 140                 


Leu Glu Xaa Tyr Leu Lys Ile Ala Arg Leu Tyr Leu Glu Asp Asp Asp 
145                 150                 155                 160 


Pro Val Gln Ala Glu Ala Tyr Ile Asn Arg Ala Ser Leu Leu Gln Asn 
                165                 170                 175     


Glu Ser Xaa Asn Glu Gln Leu Gln Ile His Tyr Lys Val Cys Tyr Ala 
            180                 185                 190         


Arg Val Leu Asp Tyr Arg Arg Lys Phe Ile Glu Ala Ala Gln Arg Tyr 
        195                 200                 205             


Asn Glu Leu Ser Tyr Lys Xaa Ile Val His Glu Ser Glu Arg Leu Glu 
    210                 215                 220                 


Ala Leu Lys His Ala Leu His Cys Xaa Ile Leu Ala Ser Ala Gly Gln 
225                 230                 235                 240 


Gln Arg Ser Arg Met Leu Ala Xaa Leu Phe Lys Asp Glu Arg Cys Gln 
                245                 250                 255     


Gln Leu Ala Ala Tyr Gly Ile Leu Glu Lys Met Tyr Leu Asp Arg Ile 
            260                 265                 270         


Ile Arg Gly Asn Gln Leu Gln Glu Phe Ala Ala Met Leu Met Pro His 
        275                 280                 285             


Gln Lys Ala Xaa Xaa Ala Asp Gly Ser Ser Ile Leu Asp Arg Ala Val 
    290                 295                 300                 


Ile Glu His Asn Leu Leu Ser Ala Ser Lys Leu Tyr Asn Asn Ile Xaa 
305                 310                 315                 320 


Phe Glu Glu Leu Gly Ala Leu Leu Glu Ile Pro Ala Ala Lys His Glu 
                325                 330                 335     


Lys Pro Cys Gln Arg Gly Ile Ser Arg Ser Asn His Phe Val Ser Lys 
            340                 345                 350         


<210> 6711
<211> 406
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<400> 6711
Met Ala Ala Ala Val Arg Gln Asp Leu Ala Gln Leu Met Asn Ser Ser 
1               5                   10                  15      


Gly Ser His Lys Asp Leu Ala Gly Lys Tyr Arg Gln Ile Leu Glu Lys 
            20                  25                  30          


Ala Ile Gln Leu Ser Gly Ala Glu Gln Leu Glu Ala Leu Lys Ala Phe 
        35                  40                  45              


Val Glu Ala Met Val Asn Glu Asn Val Ser Leu Val Ile Ser Arg Gln 
    50                  55                  60                  


Leu Leu Xaa Asp Phe Cys Xaa His Leu Pro Asn Leu Pro Asp Ser Xaa 
65                  70                  75                  80  


Ala Lys Glu Ile Tyr His Phe Xaa Leu Glu Lys Ile Gln Pro Arg Val 
                85                  90                  95      


Ile Ser Phe Glu Glu Gln Val Ala Ser Ile Arg Gln His Leu Ala Ser 
            100                 105                 110         


Ile Tyr Glu Lys Glu Glu Asp Trp Arg Asn Ala Ala Gln Val Leu Val 
        115                 120                 125             


Gly Ile Pro Leu Glu Xaa Gly Gln Lys Gln Tyr Asn Val Asp Tyr Lys 
    130                 135                 140                 


Leu Glu Xaa Tyr Leu Lys Ile Ala Arg Leu Tyr Leu Glu Asp Asp Asp 
145                 150                 155                 160 


Pro Val Gln Ala Glu Ala Tyr Ile Asn Arg Ala Ser Leu Leu Gln Asn 
                165                 170                 175     


Glu Ser Xaa Asn Glu Gln Leu Gln Ile His Tyr Lys Val Cys Tyr Ala 
            180                 185                 190         


Arg Val Leu Asp Tyr Arg Arg Lys Phe Ile Glu Ala Ala Gln Arg Tyr 
        195                 200                 205             


Asn Glu Leu Ser Tyr Lys Xaa Ile Val His Glu Ser Glu Arg Leu Glu 
    210                 215                 220                 


Ala Leu Lys His Ala Leu His Cys Xaa Ile Leu Ala Ser Ala Gly Gln 
225                 230                 235                 240 


Gln Arg Ser Arg Met Leu Ala Xaa Leu Phe Lys Asp Glu Arg Cys Gln 
                245                 250                 255     


Gln Leu Ala Ala Tyr Gly Ile Leu Glu Lys Met Tyr Leu Asp Arg Ile 
            260                 265                 270         


Ile Arg Gly Asn Gln Leu Gln Glu Phe Ala Ala Met Leu Met Pro His 
        275                 280                 285             


Gln Lys Ala Xaa Xaa Ala Asp Gly Ser Ser Ile Leu Asp Arg Ala Val 
    290                 295                 300                 


Ile Glu His Asn Leu Leu Ser Ala Ser Lys Leu Tyr Asn Asn Ile Xaa 
305                 310                 315                 320 


Phe Glu Glu Leu Gly Ala Leu Leu Glu Ile Pro Ala Ala Lys Ala Glu 
                325                 330                 335     


Lys Ile Ala Ser Gln Met Ile Xaa Glu Gly Arg Met Asn Gly Phe Ile 
            340                 345                 350         


Asp Gln Ile Asp Gly Ile Val His Phe Glu Xaa Arg Glu Ala Leu Pro 
        355                 360                 365             


Xaa Trp Asp Lys Gln Ile Gln Ser Leu Cys Phe Gln Val Asn Asn Leu 
    370                 375                 380                 


Leu Glu Lys Ile Ser Gln Xaa Ala Pro Glu Trp Xaa Ala Gln Ala Met 
385                 390                 395                 400 


Glu Ala Gln Met Ala Gln 
                405     


<210> 6712
<211> 420
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<400> 6712
Met Ala Ala Ala Val Arg Gln Asp Leu Ala Gln Leu Met Asn Ser Ser 
1               5                   10                  15      


Gly Ser His Lys Asp Leu Ala Gly Lys Tyr Arg Gln Ile Leu Glu Lys 
            20                  25                  30          


Ala Ile Gln Leu Ser Gly Ala Glu Gln Leu Glu Ala Leu Lys Ala Phe 
        35                  40                  45              


Val Glu Ala Met Val Asn Glu Asn Val Ser Leu Val Ile Ser Arg Gln 
    50                  55                  60                  


Leu Leu Xaa Asp Phe Cys Xaa His Leu Pro Asn Leu Pro Asp Ser Xaa 
65                  70                  75                  80  


Ala Lys Glu Ile Tyr His Phe Xaa Leu Glu Lys Ile Gln Pro Arg Val 
                85                  90                  95      


Ile Ser Phe Glu Glu Gln Val Ala Ser Ile Arg Gln His Leu Ala Ser 
            100                 105                 110         


Ile Tyr Glu Lys Glu Glu Asp Trp Arg Asn Ala Ala Gln Val Leu Val 
        115                 120                 125             


Gly Ile Pro Leu Glu Xaa Gly Gln Lys Gln Tyr Asn Val Asp Tyr Lys 
    130                 135                 140                 


Leu Glu Xaa Tyr Leu Lys Ile Ala Arg Leu Tyr Leu Glu Asp Asp Asp 
145                 150                 155                 160 


Pro Val Gln Ala Glu Ala Tyr Ile Asn Arg Ala Ser Leu Leu Gln Asn 
                165                 170                 175     


Glu Ser Xaa Asn Glu Gln Leu Gln Ile His Tyr Lys Val Cys Tyr Ala 
            180                 185                 190         


Arg Val Leu Asp Tyr Arg Arg Lys Phe Ile Glu Ala Ala Gln Arg Tyr 
        195                 200                 205             


Asn Glu Leu Ser Tyr Lys Xaa Ile Val His Glu Ser Glu Arg Leu Glu 
    210                 215                 220                 


Ala Leu Lys His Ala Leu His Cys Xaa Ile Leu Ala Ser Ala Gly Gln 
225                 230                 235                 240 


Gln Arg Ser Arg Met Leu Ala Xaa Leu Phe Lys Asp Glu Arg Cys Gln 
                245                 250                 255     


Gln Leu Ala Ala Tyr Gly Ile Leu Glu Lys Met Tyr Leu Asp Arg Ile 
            260                 265                 270         


Ile Arg Gly Asn Gln Leu Gln Glu Phe Ala Ala Met Leu Met Pro His 
        275                 280                 285             


Gln Lys Ala Xaa Xaa Ala Asp Gly Ser Ser Ile Leu Asp Arg Ala Val 
    290                 295                 300                 


Ile Glu His Asn Leu Leu Ser Ala Ser Lys Leu Tyr Asn Asn Ile Xaa 
305                 310                 315                 320 


Phe Glu Glu Leu Gly Ala Leu Leu Glu Ile Pro Ala Ala Lys Ala Glu 
                325                 330                 335     


Lys Ile Ala Ser Gln Met Ile Xaa Glu Gly Arg Met Asn Gly Phe Ile 
            340                 345                 350         


Asp Gln Ile Asp Gly Ile Val His Phe Glu Xaa Ser Gly Asn His Gln 
        355                 360                 365             


Ser Ile Phe Cys Leu Trp Ile Tyr Leu Val Trp Ile Val His Ile Asn 
    370                 375                 380                 


Gly Ile Ile Gln Tyr Val Xaa Cys Asp Leu Leu Ala Asp Ser Xaa Gln 
385                 390                 395                 400 


His Ser Ile Phe Arg Val His Pro Cys His Gly Ser Xaa Arg Ser Pro 
                405                 410                 415     


Ala Asn Val Gly 
            420 


<210> 6713
<211> 438
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<400> 6713
Met Ala Ala Ala Val Arg Gln Asp Leu Ala Gln Leu Met Asn Ser Ser 
1               5                   10                  15      


Gly Ser His Lys Asp Leu Ala Gly Lys Tyr Arg Gln Ile Leu Glu Lys 
            20                  25                  30          


Ala Ile Gln Leu Ser Gly Ala Glu Gln Leu Glu Ala Leu Lys Ala Phe 
        35                  40                  45              


Val Glu Ala Met Val Asn Glu Asn Val Ser Leu Val Ile Ser Arg Gln 
    50                  55                  60                  


Leu Leu Xaa Asp Phe Cys Xaa His Leu Pro Asn Leu Pro Asp Ser Xaa 
65                  70                  75                  80  


Ala Lys Glu Ile Tyr His Phe Xaa Leu Glu Lys Ile Gln Pro Arg Val 
                85                  90                  95      


Ile Ser Phe Glu Glu Gln Val Ala Ser Ile Arg Gln His Leu Ala Ser 
            100                 105                 110         


Ile Tyr Glu Lys Glu Glu Asp Trp Arg Asn Ala Ala Gln Val Leu Val 
        115                 120                 125             


Gly Ile Pro Leu Glu Xaa Gly Gln Lys Gln Tyr Asn Val Asp Tyr Lys 
    130                 135                 140                 


Leu Glu Xaa Tyr Leu Lys Ile Ala Arg Leu Tyr Leu Glu Asp Asp Asp 
145                 150                 155                 160 


Pro Val Gln Ala Glu Ala Tyr Ile Asn Arg Ala Ser Leu Leu Gln Asn 
                165                 170                 175     


Glu Ser Xaa Asn Glu Gln Leu Gln Ile His Tyr Lys Val Cys Tyr Ala 
            180                 185                 190         


Arg Val Leu Asp Tyr Arg Arg Lys Phe Ile Glu Ala Ala Gln Arg Tyr 
        195                 200                 205             


Asn Glu Leu Ser Tyr Lys Xaa Ile Val His Glu Ser Glu Arg Leu Glu 
    210                 215                 220                 


Ala Leu Lys His Ala Leu His Cys Xaa Ile Leu Ala Ser Ala Gly Gln 
225                 230                 235                 240 


Gln Arg Ser Arg Met Leu Ala Xaa Leu Phe Lys Asp Glu Arg Cys Gln 
                245                 250                 255     


Gln Leu Ala Ala Tyr Gly Ile Leu Glu Lys Met Tyr Leu Asp Arg Ile 
            260                 265                 270         


Ile Arg Gly Asn Gln Leu Gln Glu Phe Ala Ala Met Leu Met Pro His 
        275                 280                 285             


Gln Lys Ala Xaa Xaa Ala Asp Glu Xaa Gly Ser Leu His Phe Ala Gln 
    290                 295                 300                 


Ala Gly Leu Glu Leu Leu Gly Ser Ser Ser Ser Ser His Leu Gly Phe 
305                 310                 315                 320 


Pro Lys Cys Trp Asp Asp Arg Gly Ser Ser Ile Leu Asp Arg Ala Val 
                325                 330                 335     


Ile Glu His Asn Leu Leu Ser Ala Ser Lys Leu Tyr Asn Asn Ile Xaa 
            340                 345                 350         


Phe Glu Glu Leu Gly Ala Leu Leu Glu Ile Pro Ala Ala Lys Ala Glu 
        355                 360                 365             


Lys Ile Ala Ser Gln Met Ile Xaa Glu Gly Arg Met Asn Gly Phe Ile 
    370                 375                 380                 


Asp Gln Ile Asp Gly Ile Val His Phe Glu Xaa Arg Glu Ala Leu Pro 
385                 390                 395                 400 


Xaa Trp Asp Lys Gln Ile Gln Ser Leu Cys Phe Gln Val Asn Asn Leu 
                405                 410                 415     


Leu Glu Lys Ile Ser Gln Xaa Ala Pro Glu Trp Xaa Ala Gln Ala Met 
            420                 425                 430         


Glu Ala Gln Met Ala Gln 
        435             


<210> 6714
<211> 334
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(311)
<223> Selenocysteine

<400> 6714
Met Ala Ala Ser Gly Ser Gly Met Ala Gln Lys Xaa Trp Glu Leu Ala 
1               5                   10                  15      


Asn Asn Met Gln Glu Ala Gln Ser Ile Asp Glu Ile Tyr Lys Tyr Asp 
            20                  25                  30          


Lys Lys Gln Gln Gln Glu Ile Leu Ala Ala Lys Pro Trp Xaa Lys Asp 
        35                  40                  45              


His His Tyr Phe Lys Tyr Cys Lys Ile Ser Ala Leu Ala Leu Leu Lys 
    50                  55                  60                  


Met Val Met His Ala Arg Ser Gly Gly Asn Leu Glu Val Met Gly Leu 
65                  70                  75                  80  


Met Leu Gly Lys Val Asp Gly Glu Xaa Met Ile Ile Met Asp Ser Phe 
                85                  90                  95      


Ala Leu Pro Val Glu Gly Xaa Glu Xaa Arg Val Asn Ala Gln Ala Ala 
            100                 105                 110         


Ala Tyr Glu Tyr Met Ala Ala Tyr Ile Glu Asn Ala Lys Gln Val Gly 
        115                 120                 125             


Arg Leu Glu Asn Ala Ile Gly Trp Tyr His Ser His Pro Gly Tyr Gly 
    130                 135                 140                 


Cys Trp Leu Ser Gly Ile Asp Val Ser Xaa Gln Met Leu Asn Gln Gln 
145                 150                 155                 160 


Phe Gln Glu Pro Phe Val Ala Val Val Ile Asp Pro Xaa Arg Xaa Ile 
                165                 170                 175     


Ser Ala Gly Lys Val Asn Leu Gly Ala Phe Arg Xaa Tyr Pro Lys Gly 
            180                 185                 190         


Tyr Lys Pro Pro Asp Glu Gly Pro Ser Glu Tyr Gln Xaa Ile Pro Leu 
        195                 200                 205             


Asn Lys Ile Glu Asp Phe Gly Val His Cys Lys Gln Tyr Tyr Ala Leu 
    210                 215                 220                 


Glu Val Ser Tyr Phe Lys Ser Ser Leu Asp Arg Lys Leu Leu Glu Leu 
225                 230                 235                 240 


Leu Trp Asn Lys Tyr Trp Val Asn Xaa Leu Ser Ser Ser Ser Leu Leu 
                245                 250                 255     


Xaa Asn Ala Asp Tyr Xaa Xaa Gly Gln Val Phe Asp Leu Ser Glu Lys 
            260                 265                 270         


Leu Glu Gln Ser Glu Ala Gln Leu Gly Arg Gly Ser Phe Met Leu Gly 
        275                 280                 285             


Leu Glu Xaa His Asp Arg Lys Ser Glu Asp Lys Leu Ala Lys Ala Xaa 
    290                 295                 300                 


Arg Asp Ser Cys Lys Xaa Xaa Ile Glu Ala Ile His Gly Leu Met Ser 
305                 310                 315                 320 


Gln Val Ile Lys Asp Lys Leu Phe Asn Gln Ile Asn Ile Ser 
                325                 330                 


<210> 6715
<211> 68
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<400> 6715
Met Ala Ala Ser Gly Ser Gly Met Ala Gln Lys Xaa Trp Glu Leu Ala 
1               5                   10                  15      


Asn Asn Met Gln Glu Ala Gln Ser Ile Asp Glu Ile Tyr Lys Tyr Asp 
            20                  25                  30          


Lys Lys Gln Gln Gln Glu Ile Leu Ala Ala Lys Pro Trp Xaa Lys Asp 
        35                  40                  45              


Lys Gly Arg Ser Gln Asp Phe Asp Ser Cys Leu Asp Phe Gln His Glu 
    50                  55                  60                  


Ser Pro Leu Leu 
65              


<210> 6716
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<400> 6716
Met Ala Ala Ser Gly Ser Gly Met Ala Gln Lys Xaa Trp Glu Leu Ala 
1               5                   10                  15      


Asn Asn Met Gln Glu Ala Gln Ser Ile Asp Glu Ile Tyr Lys Tyr Asp 
            20                  25                  30          


Lys Lys Gln Gln Gln Glu Ile Leu Ala Ala Lys Pro Trp Xaa Lys Asp 
        35                  40                  45              


Lys Gly Arg Ser Gln Asp Phe Asp Ser Cys Leu Asp Phe Gln His Glu 
    50                  55                  60                  


Val Tyr Xaa Phe Phe Ser Phe Trp Leu Lys Ser Gly Lys Ala 
65                  70                  75              


<210> 6717
<211> 57
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<400> 6717
Met Ala Ala Ser Gly Ser Gly Met Ala Gln Lys Xaa Trp Glu Leu Ala 
1               5                   10                  15      


Asn Asn Met Gln Glu Ala Gln Ser Ile Asp Glu Ile Tyr Lys Tyr Asp 
            20                  25                  30          


Lys Lys Gln Gln Gln Glu Ile Leu Ala Ala Lys Pro Trp Xaa Lys Glu 
        35                  40                  45              


Asn Gly Ser Ser Leu Cys Cys Ser Gly 
    50                  55          


<210> 6718
<211> 151
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<400> 6718
Met Val Met His Ala Arg Ser Gly Gly Asn Leu Glu Val Met Gly Leu 
1               5                   10                  15      


Met Leu Gly Lys Val Asp Gly Glu Xaa Met Ile Ile Met Asp Ser Phe 
            20                  25                  30          


Ala Leu Pro Val Glu Gly Xaa Glu Xaa Arg Val Asn Ala Gln Ala Ala 
        35                  40                  45              


Ala Tyr Glu Tyr Met Ala Ala Tyr Ile Glu Asn Ala Lys Gln Val Gly 
    50                  55                  60                  


Arg Leu Glu Asn Ala Ile Gly Trp Tyr His Ser His Pro Gly Tyr Gly 
65                  70                  75                  80  


Cys Trp Leu Ser Gly Ile Asp Val Ser Xaa Gln Met Leu Asn Gln Gln 
                85                  90                  95      


Phe Gln Glu Pro Phe Val Ala Val Val Ile Asp Pro Xaa Arg Xaa Ile 
            100                 105                 110         


Ser Ala Gly Lys Val Asn Leu Gly Ala Phe Arg Xaa Tyr Pro Lys Gly 
        115                 120                 125             


Tyr Lys Pro Pro Asp Glu Gly Pro Ser Glu Tyr Gln Xaa Ile Pro Leu 
    130                 135                 140                 


Asn Lys Ile Glu Asp Phe Gly 
145                 150     


<210> 6719
<211> 197
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<400> 6719
Met Val Met His Ala Arg Ser Gly Gly Asn Leu Glu Val Met Gly Leu 
1               5                   10                  15      


Met Leu Gly Lys Val Asp Gly Glu Xaa Met Ile Ile Met Asp Ser Phe 
            20                  25                  30          


Ala Leu Pro Val Glu Gly Xaa Glu Xaa Arg Val Asn Ala Gln Ala Ala 
        35                  40                  45              


Ala Tyr Glu Tyr Met Ala Ala Tyr Ile Glu Asn Ala Lys Gln Val Gly 
    50                  55                  60                  


Arg Leu Glu Asn Ala Ile Gly Trp Tyr His Ser His Pro Gly Tyr Gly 
65                  70                  75                  80  


Cys Trp Leu Ser Gly Ile Asp Val Ser Xaa Gln Met Leu Asn Gln Gln 
                85                  90                  95      


Phe Gln Glu Pro Phe Val Ala Val Val Ile Asp Pro Xaa Arg Xaa Ile 
            100                 105                 110         


Ser Ala Gly Lys Val Asn Leu Gly Ala Phe Arg Xaa Tyr Pro Lys Gly 
        115                 120                 125             


Tyr Lys Pro Pro Asp Glu Gly Pro Ser Glu Tyr Gln Xaa Ile Pro Leu 
    130                 135                 140                 


Asn Lys Ile Glu Asp Phe Gly Val His Cys Lys Gln Tyr Tyr Ala Leu 
145                 150                 155                 160 


Glu Val Ser Tyr Phe Lys Ser Ser Leu Asp Arg Lys Leu Leu Glu Leu 
                165                 170                 175     


Leu Trp Asn Lys Tyr Trp Val Asn Xaa Leu Ser Ser Ser Ser Leu Leu 
            180                 185                 190         


Xaa Arg Gln Val Tyr 
        195         


<210> 6720
<211> 123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 6720
Leu Gly Trp Tyr Xaa Xaa Gly Gly Pro Pro Asp Pro Ser Asp Ile His 
1               5                   10                  15      


Val His Lys Gln Val Cys Glu Ile Ile Glu Ser Pro Leu Phe Leu Lys 
            20                  25                  30          


Leu Asn Pro Met Xaa Lys His Xaa Asp Leu Pro Val Ser Val Phe Glu 
        35                  40                  45              


Ser Val Ile Asp Ile Ile Asn Gly Glu Ala Xaa Met Leu Phe Ala Glu 
    50                  55                  60                  


Leu Xaa Tyr Xaa Leu Ala Xaa Glu Glu Ala Glu Arg Ile Gly Val Asp 
65                  70                  75                  80  


His Val Ala Arg Met Xaa Ala Xaa Gly Ser Gly Glu Asn Ser Xaa Val 
                85                  90                  95      


Ala Glu His Leu Ile Ala Gln His Ser Ala Ile Lys Met Leu His Ser 
            100                 105                 110         


Arg Val Lys Leu Ile Leu Glu Arg Gly Pro Leu 
        115                 120             


<210> 6721
<211> 326
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<400> 6721
Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Xaa Asn Gly Xaa Gly Gly 
1               5                   10                  15      


Ser Ser Gly Met Glu Val Asp Ala Ala Val Pro Ser Val Met Ala Cys 
            20                  25                  30          


Gly Val Xaa Gly Ser Val Ser Val Ala Leu His Pro Leu Val Ile Leu 
        35                  40                  45              


Asn Ile Ser Asp His Trp Ile Arg Met Arg Ser Gln Glu Gly Arg Pro 
    50                  55                  60                  


Val Gln Val Ile Gly Ala Leu Ile Gly Lys Gln Glu Gly Arg Asn Ile 
65                  70                  75                  80  


Glu Val Met Asn Ser Phe Glu Leu Leu Ser His Xaa Val Glu Glu Lys 
                85                  90                  95      


Ile Ile Ile Asp Lys Glu Tyr Tyr Tyr Xaa Lys Glu Glu Gln Phe Lys 
            100                 105                 110         


Gln Val Phe Lys Glu Leu Glu Phe Leu Gly Trp Tyr Xaa Xaa Gly Gly 
        115                 120                 125             


Pro Pro Asp Pro Ser Asp Ile His Val His Lys Gln Val Cys Glu Ile 
    130                 135                 140                 


Ile Glu Ser Pro Leu Phe Leu Lys Leu Asn Pro Met Xaa Lys His Xaa 
145                 150                 155                 160 


Asp Leu Pro Val Ser Val Phe Glu Ser Val Ile Asp Ile Ile Asn Gly 
                165                 170                 175     


Glu Ala Xaa Met Leu Phe Ala Glu Leu Xaa Tyr Xaa Leu Ala Xaa Glu 
            180                 185                 190         


Glu Ala Glu Arg Ile Gly Val Asp His Val Ala Arg Met Xaa Ala Xaa 
        195                 200                 205             


Gly Ser Gly Glu Asn Ser Xaa Val Ala Glu His Leu Ile Ala Gln His 
    210                 215                 220                 


Ser Ala Ile Lys Met Leu His Ser Arg Val Lys Leu Ile Leu Glu Tyr 
225                 230                 235                 240 


Val Lys Ala Ser Glu Ala Gly Glu Val Pro Phe Asn His Glu Ile Leu 
                245                 250                 255     


Arg Glu Ala Tyr Ala Leu Cys His Cys Leu Pro Val Leu Ser Xaa Asp 
            260                 265                 270         


Lys Phe Lys Xaa Asp Phe Tyr Asp Gln Cys Asn Asp Val Gly Leu Met 
        275                 280                 285             


Ala Tyr Leu Gly Xaa Ile Xaa Lys Xaa Cys Asn Xaa Met Asn Gln Phe 
    290                 295                 300                 


Val Asn Lys Phe Asn Val Leu Tyr Asp Arg Gln Gly Ile Gly Arg Arg 
305                 310                 315                 320 


Met Arg Gly Leu Phe Phe 
                325     


<210> 6722
<211> 327
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<400> 6722
Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Xaa Asn Gly Xaa Gly Gly 
1               5                   10                  15      


Ser Ser Gly Met Glu Val Asp Ala Ala Val Val Pro Ser Val Met Ala 
            20                  25                  30          


Cys Gly Val Xaa Gly Ser Val Ser Val Ala Leu His Pro Leu Val Ile 
        35                  40                  45              


Leu Asn Ile Ser Asp His Trp Ile Arg Met Arg Ser Gln Glu Gly Arg 
    50                  55                  60                  


Pro Val Gln Val Ile Gly Ala Leu Ile Gly Lys Gln Glu Gly Arg Asn 
65                  70                  75                  80  


Ile Glu Val Met Asn Ser Phe Glu Leu Leu Ser His Xaa Val Glu Glu 
                85                  90                  95      


Lys Ile Ile Ile Asp Lys Glu Tyr Tyr Tyr Xaa Lys Glu Glu Gln Phe 
            100                 105                 110         


Lys Gln Val Phe Lys Glu Leu Glu Phe Leu Gly Trp Tyr Xaa Xaa Gly 
        115                 120                 125             


Gly Pro Pro Asp Pro Ser Asp Ile His Val His Lys Gln Val Cys Glu 
    130                 135                 140                 


Ile Ile Glu Ser Pro Leu Phe Leu Lys Leu Asn Pro Met Xaa Lys His 
145                 150                 155                 160 


Xaa Asp Leu Pro Val Ser Val Phe Glu Ser Val Ile Asp Ile Ile Asn 
                165                 170                 175     


Gly Glu Ala Xaa Met Leu Phe Ala Glu Leu Xaa Tyr Xaa Leu Ala Xaa 
            180                 185                 190         


Glu Glu Ala Glu Arg Ile Gly Val Asp His Val Ala Arg Met Xaa Ala 
        195                 200                 205             


Xaa Gly Ser Gly Glu Asn Ser Xaa Val Ala Glu His Leu Ile Ala Gln 
    210                 215                 220                 


His Ser Ala Ile Lys Met Leu His Ser Arg Val Lys Leu Ile Leu Glu 
225                 230                 235                 240 


Tyr Val Lys Ala Ser Glu Ala Gly Glu Val Pro Phe Asn His Glu Ile 
                245                 250                 255     


Leu Arg Glu Ala Tyr Ala Leu Cys His Cys Leu Pro Val Leu Ser Xaa 
            260                 265                 270         


Asp Lys Phe Lys Xaa Asp Phe Tyr Asp Gln Cys Asn Asp Val Gly Leu 
        275                 280                 285             


Met Ala Tyr Leu Gly Xaa Ile Xaa Lys Xaa Cys Asn Xaa Met Asn Gln 
    290                 295                 300                 


Phe Val Asn Lys Phe Asn Val Leu Tyr Asp Arg Gln Gly Ile Gly Arg 
305                 310                 315                 320 


Arg Met Arg Gly Leu Phe Phe 
                325         


<210> 6723
<211> 42
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<400> 6723
Met Ala Cys Gly Val Xaa Gly Ser Val Ser Val Ala Leu His Pro Leu 
1               5                   10                  15      


Val Ile Leu Asn Ile Ser Asp His Trp Ile Arg Met Arg Ser Gln Glu 
            20                  25                  30          


Gly Arg Pro Val Gln Val Ile Gly Ala Leu 
        35                  40          


<210> 6724
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<400> 6724
Met Ser Ala Glu Val Lys Val Xaa Gly Gln Asn Gln Glu Gln Phe Leu 
1               5                   10                  15      


Leu Leu Ala Lys Ser Ala Lys Gly Ala Ala Leu Ala Xaa Leu Ile His 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Asp 
        35                  40                  45              


Met Pro Asn Val Arg Glu Gly Arg Asn Trp Met Xaa Tyr Gly Ala Arg 
    50                  55                  60                  


Gly His Cys Gly Leu Gly Glu 
65                  70      


<210> 6725
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 6725
Met Ser Ala Glu Val Lys Val Xaa Gly Gln Asn Gln Glu Gln Phe Leu 
1               5                   10                  15      


Leu Leu Ala Lys Ser Ala Lys Gly Ala Ala Leu Ala Xaa Leu Ile His 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Asp 
        35                  40                  45              


Met Pro Asn Val Arg Glu Leu Ala Glu Ser Asp Phe Ala Ser Xaa Phe 
    50                  55                  60                  


Arg Leu Leu Xaa Val Phe Ala Tyr Gly Xaa Tyr Ala Asp Tyr Leu Ala 
65                  70                  75                  80  


Glu Ala Arg Asn Leu Pro Pro Leu Xaa Glu Ala Gln Lys Asn Lys Leu 
                85                  90                  95      


Arg His Leu Ser Val Val Xaa Leu Ala Ala Lys Val Lys Cys Ile Pro 
            100                 105                 110         


Tyr Ala Val Leu Leu Glu Ala Leu Ala Leu Arg Asn Val 
        115                 120                 125 


<210> 6726
<211> 192
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 6726
Met Ser Ala Glu Val Lys Val Xaa Gly Gln Asn Gln Glu Gln Phe Leu 
1               5                   10                  15      


Leu Leu Ala Lys Ser Ala Lys Gly Ala Ala Leu Ala Xaa Leu Ile His 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Asp 
        35                  40                  45              


Met Pro Asn Val Arg Glu Leu Ala Glu Ser Asp Phe Ala Ser Xaa Phe 
    50                  55                  60                  


Arg Leu Leu Xaa Val Phe Ala Tyr Gly Xaa Tyr Ala Asp Tyr Leu Ala 
65                  70                  75                  80  


Glu Ala Arg Asn Leu Pro Pro Leu Xaa Glu Ala Gln Lys Asn Lys Leu 
                85                  90                  95      


Arg His Leu Ser Val Val Xaa Leu Ala Ala Lys Val Lys Cys Ile Pro 
            100                 105                 110         


Tyr Ala Val Leu Leu Glu Ala Leu Ala Leu Arg Asn Val Arg Gln Leu 
        115                 120                 125             


Glu Asp Leu Val Ile Glu Ala Val Tyr Ala Asp Val Leu Arg Gly Ser 
    130                 135                 140                 


Leu Asp Gln Arg Asn Gln Arg Leu Glu Val Asp Tyr Ser Ile Gly Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Gln Asp Leu Ser Ala Ile Ala Arg Xaa Leu Gln Glu 
                165                 170                 175     


Trp Cys Val Gly Cys Glu Val Val Leu Ser Gly Ile Glu Glu Gln Val 
            180                 185                 190         


<210> 6727
<211> 262
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 6727
Met Ser Ala Glu Val Lys Val Xaa Gly Gln Asn Gln Glu Gln Phe Leu 
1               5                   10                  15      


Leu Leu Ala Lys Ser Ala Lys Gly Ala Ala Leu Ala Xaa Leu Ile His 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Asp 
        35                  40                  45              


Met Pro Asn Val Arg Glu Leu Ala Glu Ser Asp Phe Ala Ser Xaa Phe 
    50                  55                  60                  


Arg Leu Leu Xaa Val Phe Ala Tyr Gly Xaa Tyr Ala Asp Tyr Leu Ala 
65                  70                  75                  80  


Glu Ala Arg Asn Leu Pro Pro Leu Xaa Glu Ala Gln Lys Asn Lys Leu 
                85                  90                  95      


Arg His Leu Ser Val Val Xaa Leu Ala Ala Lys Val Lys Cys Ile Pro 
            100                 105                 110         


Tyr Ala Val Leu Leu Glu Ala Leu Ala Leu Arg Asn Val Arg Gln Leu 
        115                 120                 125             


Glu Asp Leu Val Ile Glu Ala Val Tyr Ala Asp Val Leu Arg Gly Ser 
    130                 135                 140                 


Leu Asp Gln Arg Asn Gln Arg Leu Glu Val Asp Tyr Ser Ile Gly Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Gln Asp Leu Ser Ala Ile Ala Arg Xaa Leu Gln Glu 
                165                 170                 175     


Trp Cys Val Gly Cys Glu Val Val Leu Ser Gly Ile Glu Glu Gln Val 
            180                 185                 190         


Ser Arg Ala Asn Gln His Lys Glu Gln Gln Leu Gly Leu Lys Gln Gln 
        195                 200                 205             


Ile Glu Ser Glu Ala Pro Arg Glu Arg Gln Asp Leu Val Gln Val Glu 
    210                 215                 220                 


Leu Lys Gly Leu Ser Phe Pro Pro Trp Gly Cys Gly Val Pro Ala Ala 
225                 230                 235                 240 


Cys Leu Pro Leu Arg Ser Pro Gln Arg Ala Phe Cys Ala Pro Gly Gln 
                245                 250                 255     


Leu Ile Ile Leu Gly Ser 
            260         


<210> 6728
<211> 213
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 6728
Met Ser Ala Glu Val Lys Val Xaa Gly Gln Asn Gln Glu Gln Phe Leu 
1               5                   10                  15      


Leu Leu Ala Lys Ser Ala Lys Gly Ala Ala Leu Ala Xaa Leu Ile His 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Asp 
        35                  40                  45              


Met Pro Asn Val Arg Glu Leu Ala Glu Ser Asp Phe Ala Ser Xaa Phe 
    50                  55                  60                  


Arg Leu Leu Xaa Val Phe Ala Tyr Gly Xaa Tyr Ala Asp Tyr Leu Ala 
65                  70                  75                  80  


Glu Ala Arg Asn Leu Pro Pro Leu Xaa Glu Ala Gln Lys Asn Lys Leu 
                85                  90                  95      


Arg His Leu Ser Val Val Xaa Leu Ala Ala Lys Val Lys Cys Ile Pro 
            100                 105                 110         


Tyr Ala Val Leu Leu Glu Ala Leu Ala Leu Arg Asn Val Arg Gln Leu 
        115                 120                 125             


Glu Asp Leu Val Ile Glu Ala Val Tyr Ala Asp Val Leu Arg Gly Ser 
    130                 135                 140                 


Leu Asp Gln Arg Asn Gln Arg Leu Glu Val Asp Tyr Ser Ile Gly Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Gln Asp Leu Ser Ala Ile Ala Arg Xaa Leu Gln Glu 
                165                 170                 175     


Trp Cys Val Gly Cys Glu Val Val Leu Ser Gly Ile Glu Glu Gln Val 
            180                 185                 190         


Ser Arg Ala Asn Gln His Lys Glu Gln Gln Leu Gly Leu Lys Gln Gln 
        195                 200                 205             


Ile Glu Ser Glu Val 
    210             


<210> 6729
<211> 275
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<400> 6729
Met Ser Ala Glu Val Lys Val Xaa Gly Gln Asn Gln Glu Gln Phe Leu 
1               5                   10                  15      


Leu Leu Ala Lys Ser Ala Lys Gly Ala Ala Leu Ala Xaa Leu Ile His 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Asp 
        35                  40                  45              


Met Pro Asn Val Arg Glu Leu Ala Glu Ser Asp Phe Ala Ser Xaa Phe 
    50                  55                  60                  


Arg Leu Leu Xaa Val Phe Ala Tyr Gly Xaa Tyr Ala Asp Tyr Leu Ala 
65                  70                  75                  80  


Glu Ala Arg Asn Leu Pro Pro Leu Xaa Glu Ala Gln Lys Asn Lys Leu 
                85                  90                  95      


Arg His Leu Ser Val Val Xaa Leu Ala Ala Lys Val Lys Cys Ile Pro 
            100                 105                 110         


Tyr Ala Val Leu Leu Glu Ala Leu Ala Leu Arg Asn Val Arg Gln Leu 
        115                 120                 125             


Glu Asp Leu Val Ile Glu Ala Val Tyr Ala Asp Val Leu Arg Gly Ser 
    130                 135                 140                 


Leu Asp Gln Arg Asn Gln Arg Leu Glu Val Asp Tyr Ser Ile Gly Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Gln Asp Leu Ser Ala Ile Ala Arg Xaa Leu Gln Glu 
                165                 170                 175     


Trp Cys Val Gly Cys Glu Val Val Leu Ser Gly Ile Glu Glu Gln Val 
            180                 185                 190         


Ser Arg Ala Asn Gln His Lys Glu Gln Gln Leu Gly Leu Lys Gln Gln 
        195                 200                 205             


Ile Glu Ser Glu Val Ala Asn Leu Lys Lys Xaa Ile Lys Val Xaa Xaa 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Xaa Ser Gln Asp Pro Glu Gln His Leu Xaa 
225                 230                 235                 240 


Glu Leu Arg Glu Pro Ala Pro Gly Xaa Asn Gln Arg Gln Pro Ser Lys 
                245                 250                 255     


Lys Ala Ser Lys Gly Lys Gly Leu Arg Gly Ser Ala Lys Ile Trp Ser 
            260                 265                 270         


Lys Ser Asn 
        275 


<210> 6730
<211> 62
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<400> 6730
Met Ser Ala Glu Val Lys Val Xaa Gly Gln Asn Gln Glu Gln Phe Leu 
1               5                   10                  15      


Leu Leu Ala Lys Ser Ala Lys Gly Ala Ala Leu Ala Xaa Leu Ile His 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Asp 
        35                  40                  45              


Met Pro Asn Val Arg Glu Leu Lys Pro Gly Ile Phe Leu His 
    50                  55                  60          


<210> 6731
<211> 60
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<400> 6731
Met Ser Ala Glu Val Lys Val Xaa Gly Gln Asn Gln Glu Gln Phe Leu 
1               5                   10                  15      


Leu Leu Ala Lys Ser Ala Lys Gly Ala Ala Leu Ala Xaa Leu Ile His 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Asp 
        35                  40                  45              


Met Pro Asn Val Arg Glu Arg His Met Ala Asn Cys 
    50                  55                  60  


<210> 6732
<211> 56
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<400> 6732
Met Ser Ala Glu Val Lys Val Xaa Gly Gln Asn Gln Glu Gln Phe Leu 
1               5                   10                  15      


Leu Leu Ala Lys Ser Ala Lys Gly Ala Ala Leu Ala Xaa Leu Ile His 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Asp 
        35                  40                  45              


Met Pro Asn Val Arg Glu Trp Asn 
    50                  55      


<210> 6733
<211> 54
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<400> 6733
Met Ala Gly Glu Gln Lys Pro Ser Ser Asn Leu Leu Glu Gln Phe Ile 
1               5                   10                  15      


Leu Leu Ala Lys Gly Xaa Ser Gly Ser Ala Leu Xaa Ala Leu Ile Ser 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Glu 
        35                  40                  45              


Leu Ala Asn Val Gln Glu 
    50                  


<210> 6734
<211> 150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 6734
Met Ala Gly Glu Gln Lys Pro Ser Ser Asn Leu Leu Glu Gln Phe Ile 
1               5                   10                  15      


Leu Leu Ala Lys Gly Xaa Ser Gly Ser Ala Leu Xaa Ala Leu Ile Ser 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Glu 
        35                  40                  45              


Leu Ala Asn Val Gln Glu Cys Ile Pro Tyr Ser Val Leu Leu Lys Asp 
    50                  55                  60                  


Leu Glu Met Arg Asn Leu Arg Glu Leu Glu Asp Leu Ile Ile Glu Ala 
65                  70                  75                  80  


Val Tyr Xaa Asp Ile Ile Gln Gly Lys Leu Asp Gln Arg Asn Gln Leu 
                85                  90                  95      


Leu Glu Val Asp Phe Cys Ile Gly Arg Asp Ile Arg Lys Lys Asp Ile 
            100                 105                 110         


Asn Asn Ile Val Lys Xaa Leu His Glu Trp Cys Asp Gly Cys Glu Ala 
        115                 120                 125             


Val Leu Leu Gly Ile Glu Gln Gln Val Leu Arg Ala Asn Gln Tyr Lys 
    130                 135                 140                 


Glu Asn His Asn Arg Xaa 
145                 150 


<210> 6735
<211> 209
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<400> 6735
Met Ala Gly Glu Gln Lys Pro Ser Ser Asn Leu Leu Glu Gln Phe Ile 
1               5                   10                  15      


Leu Leu Ala Lys Gly Xaa Ser Gly Ser Ala Leu Xaa Ala Leu Ile Ser 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Glu 
        35                  40                  45              


Leu Ala Asn Val Gln Glu Cys Ile Pro Tyr Ser Val Leu Leu Lys Asp 
    50                  55                  60                  


Leu Glu Met Arg Asn Leu Arg Glu Leu Glu Asp Leu Ile Ile Glu Ala 
65                  70                  75                  80  


Val Tyr Xaa Asp Ile Ile Gln Gly Lys Leu Asp Gln Arg Asn Gln Leu 
                85                  90                  95      


Leu Glu Val Asp Phe Cys Ile Gly Arg Asp Ile Arg Lys Lys Asp Ile 
            100                 105                 110         


Asn Asn Ile Val Lys Xaa Leu His Glu Trp Cys Asp Gly Cys Glu Ala 
        115                 120                 125             


Val Leu Leu Gly Ile Glu Gln Gln Val Leu Arg Ala Asn Gln Tyr Lys 
    130                 135                 140                 


Glu Asn His Asn Arg Xaa Gln Gln Gln Val Glu Ala Glu Val Xaa Asn 
145                 150                 155                 160 


Ile Lys Lys Xaa Leu Lys Ala Xaa Ala Ser Ser Ser Ala Gln Glu Met 
                165                 170                 175     


Glu Gln Gln Leu Ala Glu Arg Glu Cys Pro Pro His Ala Glu Gln Arg 
            180                 185                 190         


Gln Pro Xaa Lys Lys Met Ser Lys Val Lys Gly Leu Val Ser Ser Arg 
        195                 200                 205             


His 
    


<210> 6736
<211> 62
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<400> 6736
Met Ala Gly Glu Gln Lys Pro Ser Ser Asn Leu Leu Glu Gln Phe Ile 
1               5                   10                  15      


Leu Leu Ala Lys Gly Xaa Ser Gly Ser Ala Leu Xaa Ala Leu Ile Ser 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Glu 
        35                  40                  45              


Leu Ala Asn Val Gln Glu Asp Gly Leu Asp Leu Leu Xaa Ser 
    50                  55                  60          


<210> 6737
<211> 278
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<400> 6737
Met Ala Gly Glu Gln Lys Pro Ser Ser Asn Leu Leu Glu Gln Phe Ile 
1               5                   10                  15      


Leu Leu Ala Lys Gly Xaa Ser Gly Ser Ala Leu Xaa Ala Leu Ile Ser 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Glu 
        35                  40                  45              


Leu Ala Asn Val Gln Glu Leu Ala Glu Gly Ala Asn Ala Ala Tyr Leu 
    50                  55                  60                  


Gln Leu Leu Asn Leu Phe Ala Tyr Gly Xaa Tyr Pro Asp Tyr Ile Ala 
65                  70                  75                  80  


Asn Lys Glu Ser Leu Pro Glu Leu Ser Xaa Ala Gln Gln Asn Lys Leu 
                85                  90                  95      


Lys His Leu Xaa Ile Val Ser Leu Ala Ser Arg Met Lys Cys Ile Pro 
            100                 105                 110         


Tyr Ser Val Leu Leu Lys Asp Leu Glu Met Arg Asn Leu Arg Glu Leu 
        115                 120                 125             


Glu Asp Leu Ile Ile Glu Ala Val Tyr Xaa Asp Ile Ile Gln Gly Lys 
    130                 135                 140                 


Leu Asp Gln Arg Asn Gln Leu Leu Glu Val Asp Phe Cys Ile Gly Arg 
145                 150                 155                 160 


Asp Ile Arg Lys Lys Asp Ile Asn Asn Ile Val Lys Xaa Leu His Glu 
                165                 170                 175     


Trp Cys Asp Gly Cys Glu Ala Val Leu Leu Gly Ile Glu Gln Gln Val 
            180                 185                 190         


Leu Arg Ala Asn Gln Tyr Lys Glu Asn His Asn Arg Xaa Gln Gln Gln 
        195                 200                 205             


Val Glu Ala Glu Ile Ala Cys Phe Gln Arg Glu Lys Arg Asp Val Pro 
    210                 215                 220                 


Leu Leu Asn Leu Ile Xaa Xaa Ala Phe Phe Trp Leu Pro Xaa Ser Arg 
225                 230                 235                 240 


Arg His Ser Lys Pro Pro His Pro Pro Arg Leu Arg Arg Trp Ser Ser 
                245                 250                 255     


Ser Trp Leu Asn Gly Ser Val Pro Leu Xaa Leu Ser Arg Gly Ser Pro 
            260                 265                 270         


Pro Arg Arg Cys Pro Lys 
        275             


<210> 6738
<211> 273
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<400> 6738
Met Ala Gly Glu Gln Lys Pro Ser Ser Asn Leu Leu Glu Gln Phe Ile 
1               5                   10                  15      


Leu Leu Ala Lys Gly Xaa Ser Gly Ser Ala Leu Xaa Ala Leu Ile Ser 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Glu 
        35                  40                  45              


Leu Ala Asn Val Gln Glu Leu Ala Glu Gly Ala Asn Ala Ala Tyr Leu 
    50                  55                  60                  


Gln Leu Leu Asn Leu Phe Ala Tyr Gly Xaa Tyr Pro Asp Tyr Ile Ala 
65                  70                  75                  80  


Asn Lys Glu Ser Leu Pro Glu Leu Ser Xaa Ala Gln Gln Asn Lys Leu 
                85                  90                  95      


Lys His Leu Xaa Ile Val Ser Leu Ala Ser Arg Met Lys Cys Ile Pro 
            100                 105                 110         


Tyr Ser Val Leu Leu Lys Asp Leu Glu Met Arg Asn Leu Arg Glu Leu 
        115                 120                 125             


Glu Asp Leu Ile Ile Glu Ala Val Tyr Xaa Asp Ile Ile Gln Gly Lys 
    130                 135                 140                 


Leu Asp Gln Arg Asn Gln Leu Leu Glu Val Asp Phe Cys Ile Gly Arg 
145                 150                 155                 160 


Asp Ile Arg Lys Lys Asp Ile Asn Asn Ile Val Lys Xaa Leu His Glu 
                165                 170                 175     


Trp Cys Asp Gly Cys Glu Ala Val Leu Leu Gly Ile Glu Gln Gln Val 
            180                 185                 190         


Leu Arg Ala Asn Gln Tyr Lys Glu Asn His Asn Arg Xaa Gln Gln Gln 
        195                 200                 205             


Val Glu Ala Glu Arg Glu Lys Arg Asp Val Pro Leu Leu Asn Leu Ile 
    210                 215                 220                 


Xaa Xaa Ala Phe Phe Trp Leu Pro Xaa Ser Arg Arg His Ser Lys Pro 
225                 230                 235                 240 


Pro His Pro Pro Arg Leu Arg Arg Trp Ser Ser Ser Trp Leu Asn Gly 
                245                 250                 255     


Ser Val Pro Leu Xaa Leu Ser Arg Gly Ser Pro Pro Arg Arg Cys Pro 
            260                 265                 270         


Lys 
    


<210> 6739
<211> 264
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<400> 6739
Met Ala Gly Glu Gln Lys Pro Ser Ser Asn Leu Leu Glu Gln Phe Ile 
1               5                   10                  15      


Leu Leu Ala Lys Gly Xaa Ser Gly Ser Ala Leu Xaa Ala Leu Ile Ser 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Glu 
        35                  40                  45              


Leu Ala Asn Val Gln Glu Leu Ala Glu Gly Ala Asn Ala Ala Tyr Leu 
    50                  55                  60                  


Gln Leu Leu Asn Leu Phe Ala Tyr Gly Xaa Tyr Pro Asp Tyr Ile Ala 
65                  70                  75                  80  


Asn Lys Glu Ser Leu Pro Glu Leu Ser Xaa Ala Gln Gln Asn Lys Leu 
                85                  90                  95      


Lys His Leu Xaa Ile Val Ser Leu Ala Ser Arg Met Lys Cys Ile Pro 
            100                 105                 110         


Tyr Ser Val Leu Leu Lys Asp Leu Glu Met Arg Asn Leu Arg Glu Leu 
        115                 120                 125             


Glu Asp Leu Ile Ile Glu Ala Val Tyr Xaa Asp Ile Ile Gln Gly Lys 
    130                 135                 140                 


Leu Asp Gln Arg Asn Gln Leu Leu Glu Val Asp Phe Cys Ile Gly Arg 
145                 150                 155                 160 


Asp Ile Arg Lys Lys Asp Ile Asn Asn Ile Val Lys Xaa Leu His Glu 
                165                 170                 175     


Trp Cys Asp Gly Cys Glu Ala Val Leu Leu Gly Ile Glu Gln Gln Val 
            180                 185                 190         


Leu Arg Ala Asn Gln Tyr Lys Glu Asn His Asn Arg Xaa Gln Gln Gln 
        195                 200                 205             


Val Glu Ala Glu Val Xaa Asn Ile Lys Lys Xaa Leu Lys Ala Xaa Ala 
    210                 215                 220                 


Ser Ser Ser Ala Gln Glu Met Glu Gln Gln Leu Ala Glu Arg Glu Cys 
225                 230                 235                 240 


Pro Pro His Ala Glu Gln Arg Gln Pro Xaa Lys Lys Met Ser Lys Val 
                245                 250                 255     


Lys Gly Leu Val Ser Ser Arg His 
            260                 


<210> 6740
<211> 103
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 6740
Met Ala Gly Glu Gln Lys Pro Ser Ser Asn Leu Leu Glu Gln Phe Ile 
1               5                   10                  15      


Leu Leu Ala Lys Gly Xaa Ser Gly Ser Ala Leu Xaa Ala Leu Ile Ser 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Glu 
        35                  40                  45              


Leu Ala Asn Val Gln Glu Leu Ala Glu Gly Ala Asn Ala Ala Tyr Leu 
    50                  55                  60                  


Gln Leu Leu Asn Leu Phe Ala Tyr Gly Xaa Tyr Pro Asp Tyr Ile Val 
65                  70                  75                  80  


Tyr Pro Leu Leu Arg Val Ala Glu Arg Pro Gly Asp Ala Glu Ser Pro 
                85                  90                  95      


Gly Xaa Arg Arg Pro Tyr His 
            100             


<210> 6741
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<400> 6741
Met Ala Gly Glu Gln Lys Pro Ser Ser Asn Leu Leu Glu Gln Phe Ile 
1               5                   10                  15      


Leu Leu Ala Lys Gly Xaa Ser Gly Ser Ala Leu Xaa Ala Leu Ile Ser 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Glu 
        35                  40                  45              


Leu Ala Asn Val Gln Glu Pro Gly Trp Ser Arg Ser Pro Asp Leu Met 
    50                  55                  60                  


Ile His Pro Pro Arg Pro Pro Lys Val Leu Gly Leu Gln Ala 
65                  70                  75              


<210> 6742
<211> 62
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<400> 6742
Met Ala Gly Glu Gln Lys Pro Ser Ser Asn Leu Leu Glu Gln Phe Ile 
1               5                   10                  15      


Leu Leu Ala Lys Gly Xaa Ser Gly Ser Ala Leu Xaa Ala Leu Ile Ser 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Glu 
        35                  40                  45              


Leu Ala Asn Val Gln Glu Pro Xaa Arg Arg Ala Cys Gln Asn 
    50                  55                  60          


<210> 6743
<211> 68
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<400> 6743
Met Ala Gly Glu Gln Lys Pro Ser Ser Asn Leu Leu Glu Gln Phe Ile 
1               5                   10                  15      


Leu Leu Ala Lys Gly Xaa Ser Gly Ser Ala Leu Xaa Ala Leu Ile Ser 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Glu 
        35                  40                  45              


Leu Ala Asn Val Gln Glu Arg Arg Gly Phe Xaa Leu Leu Ala Arg Met 
    50                  55                  60                  


Val Ser Ile Ser 
65              


<210> 6744
<211> 157
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<400> 6744
Met Lys Cys Ile Pro Tyr Ser Val Leu Leu Lys Asp Leu Glu Met Arg 
1               5                   10                  15      


Asn Leu Arg Glu Leu Glu Asp Leu Ile Ile Glu Ala Val Tyr Xaa Asp 
            20                  25                  30          


Ile Ile Gln Gly Lys Leu Asp Gln Arg Asn Gln Leu Leu Glu Val Asp 
        35                  40                  45              


Phe Cys Ile Gly Arg Asp Ile Arg Lys Lys Asp Ile Asn Asn Ile Val 
    50                  55                  60                  


Lys Xaa Leu His Glu Trp Cys Asp Gly Cys Glu Ala Val Leu Leu Gly 
65                  70                  75                  80  


Ile Glu Gln Gln Val Leu Arg Ala Asn Gln Tyr Lys Glu Asn His Asn 
                85                  90                  95      


Arg Xaa Gln Gln Gln Val Glu Ala Glu Val Xaa Asn Ile Lys Lys Xaa 
            100                 105                 110         


Leu Lys Ala Xaa Ala Ser Ser Ser Ala Gln Glu Met Glu Gln Gln Leu 
        115                 120                 125             


Ala Glu Arg Glu Cys Pro Pro His Ala Glu Gln Arg Gln Pro Xaa Lys 
    130                 135                 140                 


Lys Met Ser Lys Val Lys Gly Leu Val Ser Ser Arg His 
145                 150                 155         


<210> 6745
<211> 230
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<400> 6745
Met Xaa Ala Arg Arg Glu Leu Xaa Ser Val Tyr Met Glu Leu Arg His 
1               5                   10                  15      


Leu Gln Ile Met Leu Ala Glu Gly Ala Asn Ala Ala Tyr Leu Gln Leu 
            20                  25                  30          


Leu Asn Leu Phe Ala Tyr Gly Xaa Tyr Pro Asp Tyr Ile Ala Asn Lys 
        35                  40                  45              


Glu Ser Leu Pro Glu Leu Ser Xaa Ala Gln Gln Asn Lys Leu Lys His 
    50                  55                  60                  


Leu Xaa Ile Val Ser Leu Ala Ser Arg Met Lys Cys Ile Pro Tyr Ser 
65                  70                  75                  80  


Val Leu Leu Lys Asp Leu Glu Met Arg Asn Leu Arg Glu Leu Glu Asp 
                85                  90                  95      


Leu Ile Ile Glu Ala Val Tyr Xaa Asp Ile Ile Gln Gly Lys Leu Asp 
            100                 105                 110         


Gln Arg Asn Gln Leu Leu Glu Val Asp Phe Cys Ile Gly Arg Asp Ile 
        115                 120                 125             


Arg Lys Lys Asp Ile Asn Asn Ile Val Lys Xaa Leu His Glu Trp Cys 
    130                 135                 140                 


Asp Gly Cys Glu Ala Val Leu Leu Gly Ile Glu Gln Gln Val Leu Arg 
145                 150                 155                 160 


Ala Asn Gln Tyr Lys Glu Asn His Asn Arg Xaa Gln Gln Gln Val Glu 
                165                 170                 175     


Ala Glu Val Xaa Asn Ile Lys Lys Xaa Leu Lys Ala Xaa Ala Ser Ser 
            180                 185                 190         


Ser Ala Gln Glu Met Glu Gln Gln Leu Ala Glu Arg Glu Cys Pro Pro 
        195                 200                 205             


His Ala Glu Gln Arg Gln Pro Xaa Lys Lys Met Ser Lys Val Lys Gly 
    210                 215                 220                 


Leu Val Ser Ser Arg His 
225                 230 


<210> 6746
<211> 49
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<400> 6746
Xaa Tyr Val Phe Gly Glu Leu Leu Glu Leu Ala Asn Val Gln Glu Leu 
1               5                   10                  15      


Ala Glu Gly Ala Asn Ala Ala Tyr Leu Gln Leu Leu Asn Leu Phe Ala 
            20                  25                  30          


Tyr Gly Xaa Tyr Pro Asp Tyr Ile Asp Glu Ile Leu Glu Asp Trp Cys 
        35                  40                  45              


Leu 
    


<210> 6747
<211> 172
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<400> 6747
Tyr Xaa Asp Ile Ile Gln Gly Lys Leu Asp Gln Arg Asn Gln Leu Leu 
1               5                   10                  15      


Glu Val Asp Phe Cys Ile Gly Arg Asp Ile Arg Lys Lys Asp Ile Asn 
            20                  25                  30          


Asn Ile Val Lys Xaa Leu His Glu Trp Cys Asp Gly Cys Glu Ala Val 
        35                  40                  45              


Leu Leu Gly Ile Glu Gln Gln Val Leu Arg Ala Asn Gln Tyr Lys Glu 
    50                  55                  60                  


Asn His Asn Arg Xaa Gln Gln Gln Val Glu Ala Glu Val Xaa Asn Ile 
65                  70                  75                  80  


Lys Lys Xaa Leu Lys Ala Xaa Ala Ser Ser Ser Ala Gln Glu Met Glu 
                85                  90                  95      


Gln Gln Leu Ala Glu Arg Glu Cys Pro Pro His Ala Glu Gln Arg Gln 
            100                 105                 110         


Pro Xaa Lys Lys Met Ser Lys Val Lys Gly Pro Ser Cys Pro Leu Glu 
        115                 120                 125             


Leu Pro Ala Asn Ala Cys Ser Pro Lys Ile Phe Asn Ser Ser Trp Leu 
    130                 135                 140                 


His Leu Gly Arg Asp Gly Gly Ile Asp Ala Pro Leu Ser Ala Glu Gly 
145                 150                 155                 160 


Pro Val Ala Ala Ser Val Phe Ser Pro Leu Leu Gly 
                165                 170         


<210> 6748
<211> 160
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<400> 6748
Met Asn Asn Ala Arg Tyr Leu Trp Lys Arg Ile Pro Pro Ala Ile Lys 
1               5                   10                  15      


Ser Ala Asn Ser Glu Leu Gly Gly Ile Trp Ser Val Gly Gln Arg Ile 
            20                  25                  30          


Trp Gln Arg Asp Phe Pro Gly Ile Tyr Xaa Xaa Ile Asn Ala His Gln 
        35                  40                  45              


Trp Ser Glu Xaa Val Gln Pro Ile Met Glu Ala Leu Arg Asp Ala Xaa 
    50                  55                  60                  


Arg Arg Arg Ala Phe Ala Leu Val Ser Gln Ala Tyr Xaa Ser Ile Ile 
65                  70                  75                  80  


Ala Asp Asp Phe Ala Ala Phe Val Gly Leu Pro Val Glu Glu Ala Val 
                85                  90                  95      


Lys Gly Ile Leu Glu Gln Gly Trp Gln Ala Asp Ser Xaa Xaa Arg Met 
            100                 105                 110         


Val Leu Pro Arg Lys Pro Val Ala Gly Ala Leu Asp Val Ser Phe Asn 
        115                 120                 125             


Lys Phe Ile Pro Leu Ser Glu Pro Ala Pro Val Pro Pro Ile Pro Asn 
    130                 135                 140                 


Glu Gln Gln Leu Ala Arg Leu Xaa Asp Tyr Val Ala Phe Leu Glu Asn 
145                 150                 155                 160 


<210> 6749
<211> 64
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<400> 6749
Met Pro Val Ala Val Met Ala Glu Ser Ala Phe Ser Phe Lys Lys Leu 
1               5                   10                  15      


Leu Asp Gln Cys Glu Asn Gln Glu Leu Glu Ala Pro Gly Gly Ile Ala 
            20                  25                  30          


Xaa Pro Pro Val Tyr Gly Gln Leu Leu Ala Leu Tyr Leu Leu His Asn 
        35                  40                  45              


Asp Ile Asn Phe Tyr Asp Leu Tyr Leu Leu Asn Phe Ile Tyr Asn Gln 
    50                  55                  60                  


<210> 6750
<211> 209
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<400> 6750
Met Pro Val Ala Val Met Ala Glu Ser Ala Phe Ser Phe Lys Lys Leu 
1               5                   10                  15      


Leu Asp Gln Cys Glu Asn Gln Glu Leu Glu Ala Pro Gly Gly Ile Ala 
            20                  25                  30          


Xaa Pro Pro Val Tyr Gly Gln Leu Leu Ala Leu Tyr Leu Leu His Asn 
        35                  40                  45              


Asp Met Asn Asn Ala Arg Tyr Leu Trp Lys Arg Ile Pro Pro Ala Ile 
    50                  55                  60                  


Lys Ser Ala Asn Ser Glu Leu Gly Gly Ile Trp Ser Val Gly Gln Arg 
65                  70                  75                  80  


Ile Trp Gln Arg Asp Phe Pro Gly Ile Tyr Xaa Xaa Ile Asn Ala His 
                85                  90                  95      


Gln Trp Ser Glu Xaa Val Gln Pro Ile Met Glu Ala Leu Arg Asp Ala 
            100                 105                 110         


Xaa Arg Arg Arg Ala Phe Ala Leu Val Ser Gln Ala Tyr Xaa Ser Ile 
        115                 120                 125             


Ile Ala Asp Asp Phe Ala Ala Phe Val Gly Leu Pro Val Glu Glu Ala 
    130                 135                 140                 


Val Lys Gly Ile Leu Glu Gln Gly Trp Gln Ala Asp Ser Xaa Xaa Arg 
145                 150                 155                 160 


Met Val Leu Pro Arg Lys Pro Val Ala Gly Ala Leu Asp Val Ser Phe 
                165                 170                 175     


Asn Lys Phe Ile Pro Leu Ser Glu Pro Ala Pro Val Pro Pro Ile Pro 
            180                 185                 190         


Asn Glu Gln Gln Leu Ala Arg Leu Xaa Asp Tyr Val Ala Phe Leu Glu 
        195                 200                 205             


Asn 
    


<210> 6751
<211> 173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 6751
Met Pro Val Ala Val Met Ala Glu Ser Ala Phe Ser Phe Lys Lys Leu 
1               5                   10                  15      


Leu Asp Gln Cys Glu Asn Gln Glu Leu Glu Ala Pro Gly Gly Ile Ala 
            20                  25                  30          


Xaa Pro Pro Val Tyr Gly Gln Leu Leu Ala Leu Tyr Leu Leu His Asn 
        35                  40                  45              


Asp Met Asn Asn Ala Arg Tyr Leu Trp Lys Arg Ile Pro Pro Ala Ile 
    50                  55                  60                  


Lys Ser Ala Asn Ser Glu Leu Gly Gly Ile Trp Ser Val Gly Gln Arg 
65                  70                  75                  80  


Ile Trp Gln Arg Asp Phe Pro Gly Ile Tyr Xaa Xaa Ile Asn Ala His 
                85                  90                  95      


Gln Trp Ser Glu Xaa Val Gln Pro Ile Met Glu Ala Leu Arg Gly Ile 
            100                 105                 110         


Leu Glu Gln Gly Trp Gln Ala Asp Ser Xaa Xaa Arg Met Val Leu Pro 
        115                 120                 125             


Arg Lys Pro Val Ala Gly Ala Leu Asp Val Ser Phe Asn Lys Phe Ile 
    130                 135                 140                 


Pro Leu Ser Glu Pro Ala Pro Val Pro Pro Ile Pro Asn Glu Gln Gln 
145                 150                 155                 160 


Leu Ala Arg Leu Xaa Asp Tyr Val Ala Phe Leu Glu Asn 
                165                 170             


<210> 6752
<211> 83
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<400> 6752
Xaa Ile Ile Ala Asp Asp Phe Ala Ala Phe Val Gly Leu Pro Val Glu 
1               5                   10                  15      


Glu Ala Val Lys Gly Ile Leu Glu Gln Gly Trp Gln Ala Asp Ser Xaa 
            20                  25                  30          


Xaa Arg Met Val Leu Pro Arg Lys Pro Val Ala Gly Ala Leu Asp Val 
        35                  40                  45              


Ser Phe Asn Lys Phe Ile Pro Leu Ser Glu Pro Ala Pro Val Pro Pro 
    50                  55                  60                  


Ile Pro Asn Glu Gln Gln Leu Ala Arg Leu Xaa Asp Tyr Val Ala Phe 
65                  70                  75                  80  


Leu Glu Asn 
            


<210> 6753
<211> 57
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<400> 6753
Met Lys Pro Ala Val Asp Glu Met Phe Pro Glu Gly Ala Gly Pro Tyr 
1               5                   10                  15      


Val Asp Leu Asp Glu Ala Gly Gly Ser Xaa Gly Leu Leu Met Asp Leu 
            20                  25                  30          


Ala Ala Asn Glu Lys Ala Val His Ala Asp Phe Phe Asn Asp Phe Glu 
        35                  40                  45              


Asp Leu Phe Asp Asp Asp Asp Ile Gln 
    50                  55          


<210> 6754
<211> 49
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<400> 6754
Met Trp Arg Ala Pro Glu Ala Ala Leu Arg Pro Glu Val Ser Leu Glu 
1               5                   10                  15      


Arg Arg Gly Pro Glu Met Lys Pro Ala Val Asp Glu Met Phe Pro Glu 
            20                  25                  30          


Gly Ala Gly Pro Tyr Val Asp Leu Asp Glu Ala Gly Gly Ser Xaa Gly 
        35                  40                  45              


Leu 
    


<210> 6755
<211> 252
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(245)
<223> Selenocysteine

<400> 6755
Met Trp Arg Ala Pro Glu Ala Ala Leu Arg Pro Glu Val Ser Leu Glu 
1               5                   10                  15      


Arg Arg Gly Pro Glu Met Lys Pro Ala Val Asp Glu Met Phe Pro Glu 
            20                  25                  30          


Gly Ala Gly Pro Tyr Val Asp Leu Asp Glu Val Ala Arg Ala Arg Arg 
        35                  40                  45              


Glu Ser Pro Ser Ala Gly Gly Ser Xaa Gly Leu Leu Met Asp Leu Ala 
    50                  55                  60                  


Ala Asn Glu Lys Ala Val His Ala Asp Phe Phe Asn Asp Phe Glu Asp 
65                  70                  75                  80  


Leu Phe Asp Asp Asp Asp Ile His Ser Ser Gly Leu Pro Arg Xaa Ser 
                85                  90                  95      


Gln Gln Ser Ser Met Val Pro Ala Leu Gln Arg Gly Gln Ser Glu His 
            100                 105                 110         


Gly Val Arg Gly Lys Ala Ala Glu Arg Pro Val Val Ser Glu Glu Arg 
        115                 120                 125             


Cys Glu Leu Asn Gly Arg Glu Val Ala Ala Leu Asp Arg Ala Phe Gly 
    130                 135                 140                 


Ser Xaa Gly His Gly Gln Gly Ala Glu Ala Leu Met Phe Xaa Arg Cys 
145                 150                 155                 160 


Arg Glu His Pro Leu Cys Gly Xaa Asn Lys Ala Xaa Ser Glu Gly Lys 
                165                 170                 175     


Met Gly Xaa Gly Arg Leu Arg Asn Ser Leu Arg Lys Asn Gln Ser Lys 
            180                 185                 190         


Trp Leu Gly Ser Tyr Leu Glu Val Leu Arg Xaa Xaa Arg Ser Arg Arg 
        195                 200                 205             


Glu Val Ser Glu Asp Ser Xaa Ile Ser Val Ser Xaa His Trp Arg Gly 
    210                 215                 220                 


Lys Cys Phe Lys Ser Asp Glu Xaa Pro Ser Val Ala Gly Gly Glu Glu 
225                 230                 235                 240 


Gly Lys Lys Xaa Xaa Gln Pro Cys Ile Asp Val Arg 
                245                 250         


<210> 6756
<211> 218
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (69)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<400> 6756
Met Pro Asp Tyr Phe Ser Arg Arg Ala Gly Val Phe Pro Met Lys Pro 
1               5                   10                  15      


Gly Asp Pro Gly Arg Arg Ser Asp Ser Arg Gly His Pro Cys Leu Asp 
            20                  25                  30          


Leu Arg Ala Arg Met Ser Arg Gln Val Val Arg Ser Ser Lys Phe Arg 
        35                  40                  45              


His Val Phe Gly Gln Pro Ala Lys Ala Asp Gln Cys Tyr Glu Asp Val 
    50                  55                  60                  


Arg Val Ser Gln Xaa Xaa Trp Asp Ser Gly Phe Cys Ala Val Asn Pro 
65                  70                  75                  80  


Lys Phe Val Ala Leu Ile Cys Glu Ala Ser Gly Gly Gly Ala Phe Leu 
                85                  90                  95      


Val Leu Pro Leu Gly Lys Xaa Gly Arg Val Asp Lys Asn Ala Pro Xaa 
            100                 105                 110         


Val Cys Gly His Xaa Ala Pro Val Leu Asp Ile Ala Trp Cys Pro His 
        115                 120                 125             


Asn Asp Asn Val Ile Ala Ser Gly Ser Glu Asp Cys Xaa Val Met Val 
    130                 135                 140                 


Trp Glu Ile Pro Asp Gly Gly Leu Met Leu Pro Leu Arg Glu Pro Val 
145                 150                 155                 160 


Val Xaa Leu Glu Gly His Xaa Lys Arg Val Gly Ile Val Ala Trp His 
                165                 170                 175     


Xaa Xaa Ala Gln Asn Val Leu Leu Ser Ala Gly Cys Asp Asn Val Ile 
            180                 185                 190         


Met Val Trp Asp Val Gly Xaa Gly Ala Ala Met Leu Xaa Leu Gly Pro 
        195                 200                 205             


Glu Val His Pro Asp Xaa Ile Tyr Ser Val 
    210                 215             


<210> 6757
<211> 148
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(142)
<223> Selenocysteine

<400> 6757
Met Ser Arg Gln Val Val Arg Ser Ser Lys Phe Arg His Val Phe Gly 
1               5                   10                  15      


Gln Pro Ala Lys Ala Asp Gln Cys Tyr Glu Asp Val Arg Val Ser Gln 
            20                  25                  30          


Xaa Xaa Trp Asp Ser Gly Phe Cys Ala Val Asn Pro Lys Phe Val Ala 
        35                  40                  45              


Leu Ile Cys Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro Leu 
    50                  55                  60                  


Gly Lys Xaa Gly Arg Val Asp Lys Asn Ala Pro Xaa Val Cys Gly His 
65                  70                  75                  80  


Xaa Ala Pro Val Leu Asp Ile Ala Trp Cys Pro His Asn Asp Asn Val 
                85                  90                  95      


Ile Ala Ser Gly Ser Glu Asp Cys Xaa Val Met Val Trp Glu Ile Pro 
            100                 105                 110         


Asp Gly Gly Leu Met Leu Pro Leu Arg Glu Pro Val Val Xaa Leu Glu 
        115                 120                 125             


Gly His Xaa Lys Arg Val Gly Ile Val Ala Trp His Xaa Xaa Ala Gln 
    130                 135                 140                 


Asn Val Leu Leu 
145             


<210> 6758
<211> 165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<400> 6758
Met Ser Arg Gln Val Val Arg Ser Ser Lys Phe Arg His Val Phe Gly 
1               5                   10                  15      


Gln Pro Ala Lys Ala Asp Gln Cys Tyr Glu Asp Val Arg Val Ser Gln 
            20                  25                  30          


Xaa Xaa Trp Asp Ser Gly Phe Cys Ala Val Asn Pro Lys Phe Val Ala 
        35                  40                  45              


Leu Ile Cys Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro Leu 
    50                  55                  60                  


Gly Lys Xaa Gly Arg Val Asp Lys Asn Ala Pro Xaa Val Cys Gly His 
65                  70                  75                  80  


Xaa Ala Pro Val Leu Asp Ile Ala Trp Cys Pro His Asn Asp Asn Val 
                85                  90                  95      


Ile Ala Ser Gly Ser Glu Asp Cys Xaa Val Met Val Trp Glu Ile Pro 
            100                 105                 110         


Asp Gly Gly Leu Met Leu Pro Leu Arg Glu Pro Val Val Xaa Leu Glu 
        115                 120                 125             


Gly His Xaa Lys Arg Val Gly Ile Val Ala Trp His Xaa Xaa Ala Gln 
    130                 135                 140                 


Asn Val Leu Leu Ser Ala Gly Cys Asp Asn Val Ile Met Val Trp Asp 
145                 150                 155                 160 


Val Gly Xaa Gly Ala 
                165 


<210> 6759
<211> 249
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(237)
<223> Selenocysteine

<400> 6759
Met Ser Arg Gln Val Val Arg Ser Ser Lys Phe Arg His Val Phe Gly 
1               5                   10                  15      


Gln Pro Ala Lys Ala Asp Gln Cys Tyr Glu Asp Val Arg Val Ser Gln 
            20                  25                  30          


Xaa Xaa Trp Asp Ser Gly Phe Cys Ala Val Asn Pro Lys Phe Val Ala 
        35                  40                  45              


Leu Ile Cys Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro Leu 
    50                  55                  60                  


Gly Lys Xaa Gly Arg Val Asp Lys Asn Ala Pro Xaa Val Cys Gly His 
65                  70                  75                  80  


Xaa Ala Pro Val Leu Asp Ile Ala Trp Cys Pro His Asn Asp Asn Val 
                85                  90                  95      


Ile Ala Ser Gly Ser Glu Asp Cys Xaa Val Met Val Trp Glu Ile Pro 
            100                 105                 110         


Asp Gly Gly Leu Met Leu Pro Leu Arg Glu Pro Val Val Xaa Leu Glu 
        115                 120                 125             


Gly His Xaa Lys Arg Val Gly Ile Val Ala Trp His Xaa Xaa Ala Gln 
    130                 135                 140                 


Asn Val Leu Leu Ser Ala Gly Cys Asp Asn Val Ile Met Val Trp Asp 
145                 150                 155                 160 


Val Gly Xaa Gly Ala Ala Met Leu Xaa Leu Gly Pro Glu Val His Pro 
                165                 170                 175     


Asp Xaa Ile Tyr Ser Val Asp Trp Ser Arg Asp Gly Gly Leu Ile Cys 
            180                 185                 190         


Xaa Ser Cys Arg Asp Lys Arg Val Arg Ile Ile Glu Pro Arg Lys Gly 
        195                 200                 205             


Xaa Val Val Ala Glu Lys Asp Arg Pro His Glu Gly Xaa Arg Pro Val 
    210                 215                 220                 


Arg Ala Val Phe Val Ser Glu Gly Lys Ile Leu Xaa Xaa Gly Phe Ser 
225                 230                 235                 240 


Arg Met Ser Glu Arg Gln Val Ala Leu 
                245                 


<210> 6760
<211> 389
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<400> 6760
Met Ser Arg Gln Val Val Arg Ser Ser Lys Phe Arg His Val Phe Gly 
1               5                   10                  15      


Gln Pro Ala Lys Ala Asp Gln Cys Tyr Glu Asp Val Arg Val Ser Gln 
            20                  25                  30          


Xaa Xaa Trp Asp Ser Gly Phe Cys Ala Val Asn Pro Lys Phe Val Ala 
        35                  40                  45              


Leu Ile Cys Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro Leu 
    50                  55                  60                  


Gly Lys Xaa Gly Arg Val Asp Lys Asn Ala Pro Xaa Val Cys Gly His 
65                  70                  75                  80  


Xaa Ala Pro Val Leu Asp Ile Ala Trp Cys Pro His Asn Asp Asn Val 
                85                  90                  95      


Ile Ala Ser Gly Ser Glu Asp Cys Xaa Val Met Val Trp Glu Ile Pro 
            100                 105                 110         


Asp Gly Gly Leu Met Leu Pro Leu Arg Glu Pro Val Val Xaa Leu Glu 
        115                 120                 125             


Gly His Xaa Lys Arg Val Gly Ile Val Ala Trp His Xaa Xaa Ala Gln 
    130                 135                 140                 


Asn Val Leu Leu Ser Ala Gly Cys Asp Asn Val Ile Met Val Trp Asp 
145                 150                 155                 160 


Val Gly Xaa Gly Ala Ala Met Leu Xaa Leu Gly Pro Glu Val His Pro 
                165                 170                 175     


Asp Xaa Ile Tyr Ser Val Asp Trp Ser Arg Asp Gly Gly Leu Ile Cys 
            180                 185                 190         


Xaa Ser Cys Arg Asp Lys Arg Val Arg Ile Ile Glu Pro Arg Lys Gly 
        195                 200                 205             


Xaa Val Val Ala Glu Lys Asp Arg Pro His Glu Gly Xaa Arg Pro Val 
    210                 215                 220                 


Arg Ala Val Phe Val Ser Glu Gly Lys Ile Leu Xaa Xaa Gly Phe Ser 
225                 230                 235                 240 


Arg Met Ser Glu Arg Gln Val Ala Leu Trp Asp Xaa Lys His Leu Glu 
                245                 250                 255     


Glu Pro Leu Ser Leu Gln Glu Leu Asp Xaa Ser Ser Gly Val Leu Leu 
            260                 265                 270         


Pro Phe Phe Asp Pro Asp Xaa Asn Ile Val Tyr Leu Cys Gly Lys Gly 
        275                 280                 285             


Asp Ser Ser Ile Arg Tyr Phe Glu Ile Xaa Ser Glu Ala Pro Phe Leu 
    290                 295                 300                 


His Tyr Leu Ser Met Phe Ser Ser Lys Glu Ser Gln Arg Gly Met Gly 
305                 310                 315                 320 


Tyr Met Pro Lys Arg Gly Leu Glu Val Asn Lys Cys Glu Ile Ala Arg 
                325                 330                 335     


Phe Tyr Lys Leu His Glu Arg Arg Cys Glu Pro Ile Ala Met Xaa Val 
            340                 345                 350         


Pro Arg Lys Asp Ala Val Ser Arg Leu Glu Glu Glu Met Arg Lys Leu 
        355                 360                 365             


Gln Ala Xaa Val Gln Glu Leu Gln Lys Arg Leu Asp Arg Leu Glu Glu 
    370                 375                 380                 


Xaa Val Gln Ala Lys 
385                 


<210> 6761
<211> 461
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<400> 6761
Met Ser Arg Gln Val Val Arg Ser Ser Lys Phe Arg His Val Phe Gly 
1               5                   10                  15      


Gln Pro Ala Lys Ala Asp Gln Cys Tyr Glu Asp Val Arg Val Ser Gln 
            20                  25                  30          


Xaa Xaa Trp Asp Ser Gly Phe Cys Ala Val Asn Pro Lys Phe Val Ala 
        35                  40                  45              


Leu Ile Cys Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro Leu 
    50                  55                  60                  


Gly Lys Xaa Gly Arg Val Asp Lys Asn Ala Pro Xaa Val Cys Gly His 
65                  70                  75                  80  


Xaa Ala Pro Val Leu Asp Ile Ala Trp Cys Pro His Asn Asp Asn Val 
                85                  90                  95      


Ile Ala Ser Gly Ser Glu Asp Cys Xaa Val Met Val Trp Glu Ile Pro 
            100                 105                 110         


Asp Gly Gly Leu Met Leu Pro Leu Arg Glu Pro Val Val Xaa Leu Glu 
        115                 120                 125             


Gly His Xaa Lys Arg Val Gly Ile Val Ala Trp His Xaa Xaa Ala Gln 
    130                 135                 140                 


Asn Val Leu Leu Ser Ala Gly Cys Asp Asn Val Ile Met Val Trp Asp 
145                 150                 155                 160 


Val Gly Xaa Gly Ala Ala Met Leu Xaa Leu Gly Pro Glu Val His Pro 
                165                 170                 175     


Asp Xaa Ile Tyr Ser Val Asp Trp Ser Arg Asp Gly Gly Leu Ile Cys 
            180                 185                 190         


Xaa Ser Cys Arg Asp Lys Arg Val Arg Ile Ile Glu Pro Arg Lys Gly 
        195                 200                 205             


Xaa Val Val Ala Glu Lys Asp Arg Pro His Glu Gly Xaa Arg Pro Val 
    210                 215                 220                 


Arg Ala Val Phe Val Ser Glu Gly Lys Ile Leu Xaa Xaa Gly Phe Ser 
225                 230                 235                 240 


Arg Met Ser Glu Arg Gln Val Ala Leu Trp Asp Xaa Lys His Leu Glu 
                245                 250                 255     


Glu Pro Leu Ser Leu Gln Glu Leu Asp Xaa Ser Ser Gly Val Leu Leu 
            260                 265                 270         


Pro Phe Phe Asp Pro Asp Xaa Asn Ile Val Tyr Leu Cys Gly Lys Gly 
        275                 280                 285             


Asp Ser Ser Ile Arg Tyr Phe Glu Ile Xaa Ser Glu Ala Pro Phe Leu 
    290                 295                 300                 


His Tyr Leu Ser Met Phe Ser Ser Lys Glu Ser Gln Arg Gly Met Gly 
305                 310                 315                 320 


Tyr Met Pro Lys Arg Gly Leu Glu Val Asn Lys Cys Glu Ile Ala Arg 
                325                 330                 335     


Phe Tyr Lys Leu His Glu Arg Arg Cys Glu Pro Ile Ala Met Xaa Val 
            340                 345                 350         


Pro Arg Lys Ser Asp Leu Phe Gln Glu Asp Leu Tyr Pro Pro Xaa Ala 
        355                 360                 365             


Gly Pro Asp Pro Ala Leu Xaa Ala Glu Glu Trp Leu Gly Gly Arg Asp 
    370                 375                 380                 


Ala Gly Pro Leu Leu Ile Ser Leu Lys Asp Gly Tyr Val Pro Pro Lys 
385                 390                 395                 400 


Ser Arg Glu Leu Arg Val Asn Arg Gly Leu Asp Xaa Gly Arg Arg Arg 
                405                 410                 415     


Ala Ala Pro Glu Ala Ser Gly Xaa Pro Ser Ser Asp Ala Val Ser Arg 
            420                 425                 430         


Leu Glu Glu Glu Met Arg Lys Leu Gln Ala Xaa Val Gln Glu Leu Gln 
        435                 440                 445             


Lys Arg Leu Asp Arg Leu Glu Glu Xaa Val Gln Ala Lys 
    450                 455                 460     


<210> 6762
<211> 246
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<400> 6762
Met Ser Arg Gln Val Val Arg Ser Ser Lys Phe Arg His Val Phe Gly 
1               5                   10                  15      


Gln Pro Ala Lys Ala Asp Gln Cys Tyr Glu Asp Val Arg Val Ser Gln 
            20                  25                  30          


Xaa Xaa Trp Asp Ser Gly Phe Cys Ala Val Asn Pro Lys Phe Val Ala 
        35                  40                  45              


Leu Ile Cys Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro Leu 
    50                  55                  60                  


Gly Lys Val Trp Glu Ile Pro Asp Gly Gly Leu Met Leu Pro Leu Arg 
65                  70                  75                  80  


Glu Pro Val Val Xaa Leu Glu Gly His Xaa Lys Arg Val Gly Ile Val 
                85                  90                  95      


Ala Trp His Xaa Xaa Ala Gln Asn Val Leu Leu Ser Ala Gly Cys Asp 
            100                 105                 110         


Asn Val Ile Met Val Trp Asp Val Gly Xaa Gly Ala Ala Met Leu Xaa 
        115                 120                 125             


Leu Gly Pro Glu Val His Pro Asp Xaa Ile Tyr Ser Val Asp Trp Ser 
    130                 135                 140                 


Arg Asp Gly Gly Leu Ile Cys Xaa Ser Cys Arg Asp Lys Arg Val Arg 
145                 150                 155                 160 


Ile Ile Glu Pro Arg Lys Gly Xaa Val Val Ala Glu Lys Asp Arg Pro 
                165                 170                 175     


His Glu Gly Xaa Arg Pro Val Arg Ala Val Phe Val Ser Glu Gly Lys 
            180                 185                 190         


Ile Leu Xaa Xaa Gly Phe Ser Arg Met Ser Glu Arg Gln Val Ala Leu 
        195                 200                 205             


Trp Asp Xaa Lys His Leu Glu Glu Pro Leu Ser Leu Gln Glu Leu Asp 
    210                 215                 220                 


Xaa Ser Ser Gly Val Leu Leu Pro Phe Phe Asp Pro Asp Xaa Asn Ile 
225                 230                 235                 240 


Val Tyr Leu Cys Gly Lys 
                245     


<210> 6763
<211> 159
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<400> 6763
Met Arg Arg Val Val Arg Gln Ser Lys Phe Arg His Val Phe Gly Gln 
1               5                   10                  15      


Ala Val Lys Asn Asp Gln Cys Tyr Asp Asp Ile Arg Val Ser Arg Val 
            20                  25                  30          


Xaa Trp Asp Ser Ser Phe Cys Ala Val Asn Pro Arg Phe Val Ala Ile 
        35                  40                  45              


Ile Ile Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro Leu His 
    50                  55                  60                  


Lys Xaa Gly Arg Ile Asp Lys Ser Tyr Pro Xaa Val Cys Gly His Xaa 
65                  70                  75                  80  


Gly Pro Val Leu Asp Ile Asp Trp Cys Pro His Asn Asp Gln Val Ile 
                85                  90                  95      


Ala Ser Gly Ser Glu Asp Cys Xaa Val Met Val Trp Gln Ile Pro Glu 
            100                 105                 110         


Asn Gly Leu Xaa Leu Ser Leu Xaa Glu Pro Val Val Ile Leu Glu Gly 
        115                 120                 125             


His Ser Lys Arg Val Gly Ile Val Ala Trp His Pro Xaa Ala Arg Asn 
    130                 135                 140                 


Val Leu Leu Ser Ala Glu Lys Tyr Ala Gly Xaa Asn Cys Ser Ser 
145                 150                 155                 


<210> 6764
<211> 162
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 6764
Met Arg Arg Val Val Arg Gln Ser Lys Phe Arg His Val Phe Gly Gln 
1               5                   10                  15      


Ala Val Lys Asn Asp Gln Cys Tyr Asp Asp Ile Arg Val Ser Arg Val 
            20                  25                  30          


Xaa Trp Asp Ser Ser Phe Cys Ala Val Asn Pro Arg Phe Val Ala Ile 
        35                  40                  45              


Ile Ile Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro Leu His 
    50                  55                  60                  


Lys Xaa Gly Arg Ile Asp Lys Ser Tyr Pro Xaa Val Cys Gly His Xaa 
65                  70                  75                  80  


Gly Pro Val Leu Asp Ile Asp Trp Cys Pro His Asn Asp Gln Val Ile 
                85                  90                  95      


Ala Ser Gly Ser Glu Asp Cys Xaa Val Met Val Trp Gln Ile Pro Glu 
            100                 105                 110         


Asn Gly Leu Xaa Leu Ser Leu Xaa Glu Pro Val Val Ile Leu Glu Gly 
        115                 120                 125             


His Ser Lys Arg Val Gly Ile Val Ala Trp His Pro Xaa Ala Arg Asn 
    130                 135                 140                 


Val Leu Leu Ser Ala Gly Cys Asp Asn Ala Ile Ile Ile Trp Asn Val 
145                 150                 155                 160 


Gly Xaa 
        


<210> 6765
<211> 163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 6765
Met Arg Arg Val Val Arg Gln Ser Lys Phe Arg His Val Phe Gly Gln 
1               5                   10                  15      


Ala Val Lys Asn Asp Gln Cys Tyr Asp Asp Ile Arg Val Ser Arg Val 
            20                  25                  30          


Xaa Trp Asp Ser Ser Phe Cys Ala Val Asn Pro Arg Phe Val Ala Ile 
        35                  40                  45              


Ile Ile Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro Leu His 
    50                  55                  60                  


Lys Xaa Gly Arg Ile Asp Lys Ser Tyr Pro Xaa Val Cys Gly His Xaa 
65                  70                  75                  80  


Gly Pro Val Leu Asp Ile Asp Trp Cys Pro His Asn Asp Gln Val Ile 
                85                  90                  95      


Ala Ser Gly Ser Glu Asp Cys Xaa Val Met Val Trp Gln Ile Pro Glu 
            100                 105                 110         


Asn Gly Leu Xaa Leu Ser Leu Xaa Glu Pro Val Val Ile Leu Glu Gly 
        115                 120                 125             


His Ser Lys Arg Val Gly Ile Val Ala Trp His Pro Xaa Ala Arg Asn 
    130                 135                 140                 


Val Leu Leu Ser Ala Gly Cys Asp Asn Ala Ile Ile Ile Trp Asn Val 
145                 150                 155                 160 


Gly Xaa Gly 
            


<210> 6766
<211> 169
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 6766
Met Arg Arg Val Val Arg Gln Ser Lys Phe Arg His Val Phe Gly Gln 
1               5                   10                  15      


Ala Val Lys Asn Asp Gln Cys Tyr Asp Asp Ile Arg Val Ser Arg Val 
            20                  25                  30          


Xaa Trp Asp Ser Ser Phe Cys Ala Val Asn Pro Arg Phe Val Ala Ile 
        35                  40                  45              


Ile Ile Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro Leu His 
    50                  55                  60                  


Lys Xaa Gly Arg Ile Asp Lys Ser Tyr Pro Xaa Val Cys Gly His Xaa 
65                  70                  75                  80  


Gly Pro Val Leu Asp Ile Asp Trp Cys Pro His Asn Asp Gln Val Ile 
                85                  90                  95      


Ala Ser Gly Ser Glu Asp Cys Xaa Val Met Val Trp Gln Ile Pro Glu 
            100                 105                 110         


Asn Gly Leu Xaa Leu Ser Leu Xaa Glu Pro Val Val Ile Leu Glu Gly 
        115                 120                 125             


His Ser Lys Arg Val Gly Ile Val Ala Trp His Pro Xaa Ala Arg Asn 
    130                 135                 140                 


Val Leu Leu Ser Ala Gly Cys Asp Asn Ala Ile Ile Ile Trp Asn Val 
145                 150                 155                 160 


Gly Xaa Gly Glu Ala Leu Ile Asn Leu 
                165                 


<210> 6767
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 6767
Met Arg Arg Val Val Arg Gln Ser Lys Phe Arg His Val Phe Gly Gln 
1               5                   10                  15      


Ala Val Lys Asn Asp Gln Cys Tyr Asp Asp Ile Arg Val Ser Arg Val 
            20                  25                  30          


Xaa Trp Asp Ser Ser Phe Cys Ala Val Asn Pro Arg Phe Val Ala Ile 
        35                  40                  45              


Ile Ile Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro Leu His 
    50                  55                  60                  


Lys Xaa Gly Arg Ile Asp Lys Ser Tyr Pro Xaa Val Cys Gly His Xaa 
65                  70                  75                  80  


Gly Pro Val Leu Asp Ile Asp Trp Cys Pro His Asn Asp Gln Val Ile 
                85                  90                  95      


Ala Ser Gly Ser Glu Asp Cys Xaa Val Met Val Trp Gln Ile Pro Glu 
            100                 105                 110         


Asn Gly Leu Xaa Leu Ser Leu Xaa Glu Pro Val Val Ile Leu Glu Gly 
        115                 120                 125             


His Ser Lys Arg Val Gly Ile Val Ala Trp His Pro Xaa Ala Arg Asn 
    130                 135                 140                 


Val Leu Leu Ser Ala Gly Cys Asp Asn Ala Ile Ile Ile Trp Asn Val 
145                 150                 155                 160 


Gly Xaa Gly Glu Ala Leu Ile Asn Leu Asp Asp Met His Ser Asp Met 
                165                 170                 175     


Ile Tyr Asn Val Ser 
            180     


<210> 6768
<211> 474
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<400> 6768
Met Arg Arg Val Val Arg Gln Ser Lys Phe Arg His Val Phe Gly Gln 
1               5                   10                  15      


Ala Val Lys Asn Asp Gln Cys Tyr Asp Asp Ile Arg Val Ser Arg Val 
            20                  25                  30          


Xaa Trp Asp Ser Ser Phe Cys Ala Val Asn Pro Arg Phe Val Ala Ile 
        35                  40                  45              


Ile Ile Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro Leu His 
    50                  55                  60                  


Lys Xaa Gly Arg Ile Asp Lys Ser Tyr Pro Xaa Val Cys Gly His Xaa 
65                  70                  75                  80  


Gly Pro Val Leu Asp Ile Asp Trp Cys Pro His Asn Asp Gln Val Ile 
                85                  90                  95      


Ala Ser Gly Ser Glu Asp Cys Xaa Val Met Val Trp Gln Ile Pro Glu 
            100                 105                 110         


Asn Gly Leu Xaa Leu Ser Leu Xaa Glu Pro Val Val Ile Leu Glu Gly 
        115                 120                 125             


His Ser Lys Arg Val Gly Ile Val Ala Trp His Pro Xaa Ala Arg Asn 
    130                 135                 140                 


Val Leu Leu Ser Ala Gly Cys Asp Asn Ala Ile Ile Ile Trp Asn Val 
145                 150                 155                 160 


Gly Xaa Gly Glu Ala Leu Ile Asn Leu Asp Asp Met His Ser Asp Met 
                165                 170                 175     


Ile Tyr Asn Val Ser Trp Asn Arg Asn Gly Ser Leu Ile Cys Xaa Ala 
            180                 185                 190         


Ser Lys Asp Lys Lys Val Arg Val Ile Asp Pro Arg Lys Gln Glu Ile 
        195                 200                 205             


Val Ala Glu Lys Glu Lys Ala His Glu Gly Ala Arg Pro Met Arg Ala 
    210                 215                 220                 


Ile Phe Leu Ala Asp Gly Asn Val Phe Xaa Xaa Gly Phe Ser Arg Met 
225                 230                 235                 240 


Ser Glu Arg Gln Leu Ala Leu Trp Asn Pro Lys Asn Met Gln Glu Pro 
                245                 250                 255     


Ile Ala Leu His Glu Met Asp Xaa Ser Asn Gly Val Leu Leu Pro Phe 
            260                 265                 270         


Tyr Asp Pro Asp Xaa Ser Ile Ile Tyr Leu Cys Gly Lys Gly Asp Ser 
        275                 280                 285             


Ser Ile Arg Tyr Phe Glu Ile Xaa Asp Glu Ser Pro Tyr Val His Tyr 
    290                 295                 300                 


Leu Asn Xaa Phe Ser Ser Lys Glu Pro Gln Arg Gly Met Gly Tyr Met 
305                 310                 315                 320 


Pro Lys Arg Gly Leu Asp Val Asn Lys Cys Glu Ile Ala Arg Phe Phe 
                325                 330                 335     


Lys Leu His Glu Arg Lys Cys Glu Pro Ile Ile Met Xaa Val Pro Arg 
            340                 345                 350         


Lys Ser Asp Leu Phe Gln Asp Asp Leu Tyr Pro Asp Xaa Ala Gly Pro 
        355                 360                 365             


Glu Ala Ala Leu Glu Ala Glu Glu Trp Phe Glu Gly Lys Asn Ala Asp 
    370                 375                 380                 


Pro Ile Leu Ile Ser Leu Lys His Gly Tyr Ile Pro Gly Lys Asn Arg 
385                 390                 395                 400 


Asp Leu Lys Val Val Lys Lys Asn Ile Leu Asp Ser Lys Pro Xaa Ala 
                405                 410                 415     


Asn Lys Lys Cys Asp Leu Ile Ser Ile Pro Lys Lys Xaa Xaa Asp Xaa 
            420                 425                 430         


Ala Ser Val Gln Asn Glu Ala Lys Leu Asp Glu Ile Leu Lys Glu Ile 
        435                 440                 445             


Lys Ser Ile Lys Asp Xaa Ile Cys Asn Gln Asp Glu Arg Ile Ser Lys 
    450                 455                 460                 


Leu Glu Gln Gln Met Ala Lys Ile Ala Ala 
465                 470                 


<210> 6769
<211> 151
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<400> 6769
Met Arg Arg Val Val Arg Gln Ser Lys Phe Arg His Val Phe Gly Gln 
1               5                   10                  15      


Ala Val Lys Asn Asp Gln Cys Tyr Asp Asp Ile Arg Val Ser Arg Val 
            20                  25                  30          


Xaa Trp Asp Ser Ser Phe Cys Ala Val Asn Pro Arg Phe Val Ala Ile 
        35                  40                  45              


Ile Ile Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro Leu His 
    50                  55                  60                  


Lys Xaa Gly Arg Ile Asp Lys Ser Tyr Pro Xaa Val Cys Gly His Xaa 
65                  70                  75                  80  


Gly Pro Val Leu Asp Ile Asp Trp Cys Pro His Asn Asp Gln Val Ile 
                85                  90                  95      


Ala Ser Gly Ser Glu Asp Cys Xaa Val Met Val Trp Gln Ile Pro Glu 
            100                 105                 110         


Asn Gly Leu Xaa Leu Ser Leu Xaa Glu Pro Val Val Ile Leu Glu Gly 
        115                 120                 125             


His Ser Lys Arg Val Gly Ile Val Ala Trp His Pro Xaa Ala Arg Asn 
    130                 135                 140                 


Val Leu Leu Ser Ala Gly Gly 
145                 150     


<210> 6770
<211> 480
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<400> 6770
Met Arg Trp Lys Asp Xaa Met Arg Arg Val Val Arg Gln Ser Lys Phe 
1               5                   10                  15      


Arg His Val Phe Gly Gln Ala Val Lys Asn Asp Gln Cys Tyr Asp Asp 
            20                  25                  30          


Ile Arg Val Ser Arg Val Xaa Trp Asp Ser Ser Phe Cys Ala Val Asn 
        35                  40                  45              


Pro Arg Phe Val Ala Ile Ile Ile Glu Ala Ser Gly Gly Gly Ala Phe 
    50                  55                  60                  


Leu Val Leu Pro Leu His Lys Xaa Gly Arg Ile Asp Lys Ser Tyr Pro 
65                  70                  75                  80  


Xaa Val Cys Gly His Xaa Gly Pro Val Leu Asp Ile Asp Trp Cys Pro 
                85                  90                  95      


His Asn Asp Gln Val Ile Ala Ser Gly Ser Glu Asp Cys Xaa Val Met 
            100                 105                 110         


Val Trp Gln Ile Pro Glu Asn Gly Leu Xaa Leu Ser Leu Xaa Glu Pro 
        115                 120                 125             


Val Val Ile Leu Glu Gly His Ser Lys Arg Val Gly Ile Val Ala Trp 
    130                 135                 140                 


His Pro Xaa Ala Arg Asn Val Leu Leu Ser Ala Gly Cys Asp Asn Ala 
145                 150                 155                 160 


Ile Ile Ile Trp Asn Val Gly Xaa Gly Glu Ala Leu Ile Asn Leu Asp 
                165                 170                 175     


Asp Met His Ser Asp Met Ile Tyr Asn Val Ser Trp Asn Arg Asn Gly 
            180                 185                 190         


Ser Leu Ile Cys Xaa Ala Ser Lys Asp Lys Lys Val Arg Val Ile Asp 
        195                 200                 205             


Pro Arg Lys Gln Glu Ile Val Ala Glu Lys Glu Lys Ala His Glu Gly 
    210                 215                 220                 


Ala Arg Pro Met Arg Ala Ile Phe Leu Ala Asp Gly Asn Val Phe Xaa 
225                 230                 235                 240 


Xaa Gly Phe Ser Arg Met Ser Glu Arg Gln Leu Ala Leu Trp Asn Pro 
                245                 250                 255     


Lys Asn Met Gln Glu Pro Ile Ala Leu His Glu Met Asp Xaa Ser Asn 
            260                 265                 270         


Gly Val Leu Leu Pro Phe Tyr Asp Pro Asp Xaa Ser Ile Ile Tyr Leu 
        275                 280                 285             


Cys Gly Lys Gly Asp Ser Ser Ile Arg Tyr Phe Glu Ile Xaa Asp Glu 
    290                 295                 300                 


Ser Pro Tyr Val His Tyr Leu Asn Xaa Phe Ser Ser Lys Glu Pro Gln 
305                 310                 315                 320 


Arg Gly Met Gly Tyr Met Pro Lys Arg Gly Leu Asp Val Asn Lys Cys 
                325                 330                 335     


Glu Ile Ala Arg Phe Phe Lys Leu His Glu Arg Lys Cys Glu Pro Ile 
            340                 345                 350         


Ile Met Xaa Val Pro Arg Lys Ser Asp Leu Phe Gln Asp Asp Leu Tyr 
        355                 360                 365             


Pro Asp Xaa Ala Gly Pro Glu Ala Ala Leu Glu Ala Glu Glu Trp Phe 
    370                 375                 380                 


Glu Gly Lys Asn Ala Asp Pro Ile Leu Ile Ser Leu Lys His Gly Tyr 
385                 390                 395                 400 


Ile Pro Gly Lys Asn Arg Asp Leu Lys Val Val Lys Lys Asn Ile Leu 
                405                 410                 415     


Asp Ser Lys Pro Xaa Ala Asn Lys Lys Cys Asp Leu Ile Ser Ile Pro 
            420                 425                 430         


Lys Lys Xaa Xaa Asp Xaa Ala Ser Val Gln Asn Glu Ala Lys Leu Asp 
        435                 440                 445             


Glu Ile Leu Lys Glu Ile Lys Ser Ile Lys Asp Xaa Ile Cys Asn Gln 
    450                 455                 460                 


Asp Glu Arg Ile Ser Lys Leu Glu Gln Gln Met Ala Lys Ile Ala Ala 
465                 470                 475                 480 


<210> 6771
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 6771
Met Val Trp Gln Ile Pro Glu Asn Gly Leu Xaa Leu Ser Leu Xaa Glu 
1               5                   10                  15      


Pro Val Val Ile Leu Glu Gly His Ser Lys Arg Val Gly Ile Val Ala 
            20                  25                  30          


Trp His Pro Xaa Ala Arg Asn Val Leu Leu Ser Ala Gly Cys Asp Asn 
        35                  40                  45              


Ala Ile Ile Ile Trp Asn Val Gly Xaa Gly Glu Ala Leu Ile Asn Leu 
    50                  55                  60                  


Asp Asp Met His Ser Asp Met Ile Tyr Asn Val Ser Trp Asn Arg Asn 
65                  70                  75                  80  


Gly Ser Leu Ile Cys Xaa Ala Ser Lys Asp Lys Lys Val Arg Val Ile 
                85                  90                  95      


Asp Pro Arg Lys Gln Glu Ile Val Ala Glu Lys Glu Lys Ala His Glu 
            100                 105                 110         


Gly Ala Arg Pro Met Arg Ala Ile Phe Leu Ala Asp Gly 
        115                 120                 125 


<210> 6772
<211> 369
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<400> 6772
Met Val Trp Gln Ile Pro Glu Asn Gly Leu Xaa Leu Ser Leu Xaa Glu 
1               5                   10                  15      


Pro Val Val Ile Leu Glu Gly His Ser Lys Arg Val Gly Ile Val Ala 
            20                  25                  30          


Trp His Pro Xaa Ala Arg Asn Val Leu Leu Ser Ala Gly Cys Asp Asn 
        35                  40                  45              


Ala Ile Ile Ile Trp Asn Val Gly Xaa Gly Glu Ala Leu Ile Asn Leu 
    50                  55                  60                  


Asp Asp Met His Ser Asp Met Ile Tyr Asn Val Ser Trp Asn Arg Asn 
65                  70                  75                  80  


Gly Ser Leu Ile Cys Xaa Ala Ser Lys Asp Lys Lys Val Arg Val Ile 
                85                  90                  95      


Asp Pro Arg Lys Gln Glu Ile Val Ala Glu Lys Glu Lys Ala His Glu 
            100                 105                 110         


Gly Ala Arg Pro Met Arg Ala Ile Phe Leu Ala Asp Gly Asn Val Phe 
        115                 120                 125             


Xaa Xaa Gly Phe Ser Arg Met Ser Glu Arg Gln Leu Ala Leu Trp Asn 
    130                 135                 140                 


Pro Lys Asn Met Gln Glu Pro Ile Ala Leu His Glu Met Asp Xaa Ser 
145                 150                 155                 160 


Asn Gly Val Leu Leu Pro Phe Tyr Asp Pro Asp Xaa Ser Ile Ile Tyr 
                165                 170                 175     


Leu Cys Gly Lys Gly Asp Ser Ser Ile Arg Tyr Phe Glu Ile Xaa Asp 
            180                 185                 190         


Glu Ser Pro Tyr Val His Tyr Leu Asn Xaa Phe Ser Ser Lys Glu Pro 
        195                 200                 205             


Gln Arg Gly Met Gly Tyr Met Pro Lys Arg Gly Leu Asp Val Asn Lys 
    210                 215                 220                 


Cys Glu Ile Ala Arg Phe Phe Lys Leu His Glu Arg Lys Cys Glu Pro 
225                 230                 235                 240 


Ile Ile Met Xaa Val Pro Arg Lys Ser Asp Leu Phe Gln Asp Asp Leu 
                245                 250                 255     


Tyr Pro Asp Xaa Ala Gly Pro Glu Ala Ala Leu Glu Ala Glu Glu Trp 
            260                 265                 270         


Phe Glu Gly Lys Asn Ala Asp Pro Ile Leu Ile Ser Leu Lys His Gly 
        275                 280                 285             


Tyr Ile Pro Gly Lys Asn Arg Asp Leu Lys Val Val Lys Lys Asn Ile 
    290                 295                 300                 


Leu Asp Ser Lys Pro Xaa Ala Asn Lys Lys Cys Asp Leu Ile Ser Ile 
305                 310                 315                 320 


Pro Lys Lys Xaa Xaa Asp Xaa Ala Ser Val Gln Asn Glu Ala Lys Leu 
                325                 330                 335     


Asp Glu Ile Leu Lys Glu Ile Lys Ser Ile Lys Asp Xaa Ile Cys Asn 
            340                 345                 350         


Gln Asp Glu Arg Ile Ser Lys Leu Glu Gln Gln Met Ala Lys Ile Ala 
        355                 360                 365             


Ala 
    


<210> 6773
<211> 527
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<400> 6773
Met Tyr Gly Pro Gly Ser Gln Leu Gly Lys Ser Gly Asn Asn Ser Trp 
1               5                   10                  15      


Ala Lys Glu Arg Gly Cys Ser Ile Ala Cys Gln Gly Ser Leu Xaa Ser 
            20                  25                  30          


Ala Arg Leu His Ala Pro Ser Ile Gly Glu Arg Pro Leu Ser His Met 
        35                  40                  45              


Arg Trp Lys Asp Xaa Met Arg Arg Val Val Arg Gln Ser Lys Phe Arg 
    50                  55                  60                  


His Val Phe Gly Gln Ala Val Lys Asn Asp Gln Cys Tyr Asp Asp Ile 
65                  70                  75                  80  


Arg Val Ser Arg Val Xaa Trp Asp Ser Ser Phe Cys Ala Val Asn Pro 
                85                  90                  95      


Arg Phe Val Ala Ile Ile Ile Glu Ala Ser Gly Gly Gly Ala Phe Leu 
            100                 105                 110         


Val Leu Pro Leu His Lys Xaa Gly Arg Ile Asp Lys Ser Tyr Pro Xaa 
        115                 120                 125             


Val Cys Gly His Xaa Gly Pro Val Leu Asp Ile Asp Trp Cys Pro His 
    130                 135                 140                 


Asn Asp Gln Val Ile Ala Ser Gly Ser Glu Asp Cys Xaa Val Met Val 
145                 150                 155                 160 


Trp Gln Ile Pro Glu Asn Gly Leu Xaa Leu Ser Leu Xaa Glu Pro Val 
                165                 170                 175     


Val Ile Leu Glu Gly His Ser Lys Arg Val Gly Ile Val Ala Trp His 
            180                 185                 190         


Pro Xaa Ala Arg Asn Val Leu Leu Ser Ala Gly Cys Asp Asn Ala Ile 
        195                 200                 205             


Ile Ile Trp Asn Val Gly Xaa Gly Glu Ala Leu Ile Asn Leu Asp Asp 
    210                 215                 220                 


Met His Ser Asp Met Ile Tyr Asn Val Ser Trp Asn Arg Asn Gly Ser 
225                 230                 235                 240 


Leu Ile Cys Xaa Ala Ser Lys Asp Lys Lys Val Arg Val Ile Asp Pro 
                245                 250                 255     


Arg Lys Gln Glu Ile Val Ala Glu Lys Glu Lys Ala His Glu Gly Ala 
            260                 265                 270         


Arg Pro Met Arg Ala Ile Phe Leu Ala Asp Gly Asn Val Phe Xaa Xaa 
        275                 280                 285             


Gly Phe Ser Arg Met Ser Glu Arg Gln Leu Ala Leu Trp Asn Pro Lys 
    290                 295                 300                 


Asn Met Gln Glu Pro Ile Ala Leu His Glu Met Asp Xaa Ser Asn Gly 
305                 310                 315                 320 


Val Leu Leu Pro Phe Tyr Asp Pro Asp Xaa Ser Ile Ile Tyr Leu Cys 
                325                 330                 335     


Gly Lys Gly Asp Ser Ser Ile Arg Tyr Phe Glu Ile Xaa Asp Glu Ser 
            340                 345                 350         


Pro Tyr Val His Tyr Leu Asn Xaa Phe Ser Ser Lys Glu Pro Gln Arg 
        355                 360                 365             


Gly Met Gly Tyr Met Pro Lys Arg Gly Leu Asp Val Asn Lys Cys Glu 
    370                 375                 380                 


Ile Ala Arg Phe Phe Lys Leu His Glu Arg Lys Cys Glu Pro Ile Ile 
385                 390                 395                 400 


Met Xaa Val Pro Arg Lys Ser Asp Leu Phe Gln Asp Asp Leu Tyr Pro 
                405                 410                 415     


Asp Xaa Ala Gly Pro Glu Ala Ala Leu Glu Ala Glu Glu Trp Phe Glu 
            420                 425                 430         


Gly Lys Asn Ala Asp Pro Ile Leu Ile Ser Leu Lys His Gly Tyr Ile 
        435                 440                 445             


Pro Gly Lys Asn Arg Asp Leu Lys Val Val Lys Lys Asn Ile Leu Asp 
    450                 455                 460                 


Ser Lys Pro Xaa Ala Asn Lys Lys Cys Asp Leu Ile Ser Ile Pro Lys 
465                 470                 475                 480 


Lys Xaa Xaa Asp Xaa Ala Ser Val Gln Asn Glu Ala Lys Leu Asp Glu 
                485                 490                 495     


Ile Leu Lys Glu Ile Lys Ser Ile Lys Asp Xaa Ile Cys Asn Gln Asp 
            500                 505                 510         


Glu Arg Ile Ser Lys Leu Glu Gln Gln Met Ala Lys Ile Ala Ala 
        515                 520                 525         


<210> 6774
<211> 165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<400> 6774
Ser Lys Glu Pro Gln Arg Gly Met Gly Tyr Met Pro Lys Arg Gly Leu 
1               5                   10                  15      


Asp Val Asn Lys Cys Glu Ile Ala Arg Phe Phe Lys Leu His Glu Arg 
            20                  25                  30          


Lys Cys Glu Pro Ile Ile Met Xaa Val Pro Arg Lys Ser Asp Leu Phe 
        35                  40                  45              


Gln Asp Asp Leu Tyr Pro Asp Xaa Ala Gly Pro Glu Ala Ala Leu Glu 
    50                  55                  60                  


Ala Glu Glu Trp Phe Glu Gly Lys Asn Ala Asp Pro Ile Leu Ile Ser 
65                  70                  75                  80  


Leu Lys His Gly Tyr Ile Pro Gly Lys Asn Arg Asp Leu Lys Val Val 
                85                  90                  95      


Lys Lys Asn Ile Leu Asp Ser Lys Pro Xaa Ala Asn Lys Lys Cys Asp 
            100                 105                 110         


Leu Ile Ser Ile Pro Lys Lys Xaa Xaa Asp Xaa Ala Ser Val Gln Asn 
        115                 120                 125             


Glu Ala Lys Leu Asp Glu Ile Leu Lys Glu Ile Lys Ser Ile Lys Asp 
    130                 135                 140                 


Xaa Ile Cys Asn Gln Asp Glu Arg Ile Ser Lys Leu Glu Gln Gln Met 
145                 150                 155                 160 


Ala Lys Ile Ala Ala 
                165 


<210> 6775
<211> 525
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<400> 6775
Met Ser Trp His Pro Gln Tyr Arg Ser Ser Lys Phe Arg His Val Phe 
1               5                   10                  15      


Gly Lys Pro Ala Ser Lys Glu Asn Cys Tyr Asp Ser Val Pro Ile Xaa 
            20                  25                  30          


Arg Ser Val His Asp Asn His Phe Cys Ala Val Asn Pro His Phe Ile 
        35                  40                  45              


Ala Val Val Xaa Glu Cys Ala Gly Gly Gly Ala Phe Leu Val Ile Pro 
    50                  55                  60                  


Leu His Gln Xaa Gly Lys Leu Asp Pro His Tyr Pro Lys Val Cys Gly 
65                  70                  75                  80  


His Arg Gly Asn Val Leu Asp Val Lys Trp Asn Pro Phe Asp Asp Phe 
                85                  90                  95      


Glu Ile Ala Ser Cys Ser Glu Asp Ala Xaa Ile Lys Ile Trp Ser Ile 
            100                 105                 110         


Pro Lys Gln Leu Leu Xaa Arg Asn Leu Xaa Ala Tyr Arg Lys Glu Leu 
        115                 120                 125             


Val Gly His Ala Arg Arg Val Gly Leu Val Glu Trp His Pro Xaa Ala 
    130                 135                 140                 


Ala Asn Ile Leu Phe Ser Ala Gly Tyr Asp Tyr Lys Val Met Ile Trp 
145                 150                 155                 160 


Asn Leu Asp Xaa Lys Glu Ser Val Ile Xaa Ser Pro Met Ser Xaa Ile 
                165                 170                 175     


Ser Cys His Gln Asp Val Ile Leu Ser Met Ser Phe Asn Xaa Asn Gly 
            180                 185                 190         


Ser Leu Leu Ala Xaa Xaa Cys Lys Asp Arg Lys Ile Arg Val Ile Asp 
        195                 200                 205             


Pro Arg Ala Gly Xaa Val Leu Gln Glu Ala Ser Tyr Lys Gly His Arg 
    210                 215                 220                 


Ala Ser Lys Val Leu Phe Leu Gly Asn Leu Lys Lys Leu Met Ser Xaa 
225                 230                 235                 240 


Gly Xaa Ser Arg Trp Asn Asn Arg Gln Val Ala Leu Trp Asp Gln Asp 
                245                 250                 255     


Asn Leu Ser Val Pro Leu Met Glu Glu Asp Leu Asp Gly Ser Ser Gly 
            260                 265                 270         


Val Leu Phe Pro Phe Tyr Asp Ala Asp Xaa Ser Met Leu Tyr Val Val 
        275                 280                 285             


Gly Lys Gly Asp Gly Asn Ile Arg Tyr Tyr Glu Val Ser Ala Asp Lys 
    290                 295                 300                 


Pro His Leu Ser Tyr Leu Xaa Glu Tyr Arg Ser Tyr Asn Pro Gln Lys 
305                 310                 315                 320 


Gly Ile Gly Val Met Pro Lys Arg Gly Leu Asp Val Ser Ser Cys Glu 
                325                 330                 335     


Ile Phe Arg Phe Tyr Lys Leu Ile Xaa Xaa Lys Ser Leu Ile Glu Pro 
            340                 345                 350         


Ile Ser Met Ile Val Pro Arg Arg Ser Glu Ser Tyr Gln Glu Asp Ile 
        355                 360                 365             


Tyr Pro Pro Xaa Ala Gly Ala Gln Pro Ser Leu Xaa Ala Gln Glu Trp 
    370                 375                 380                 


Leu Ser Gly Met Asn Arg Asp Pro Ile Leu Val Ser Leu Arg Pro Gly 
385                 390                 395                 400 


Ser Glu Leu Leu Arg Pro His Pro Leu Pro Ala Glu Arg Pro Ile Phe 
                405                 410                 415     


Asn Ser Met Ala Pro Ala Ser Pro Arg Leu Leu Asn Gln Xaa Glu Lys 
            420                 425                 430         


Leu Ala Ala Glu Asp Gly Trp Arg Ser Ser Ser Leu Leu Glu Glu Lys 
        435                 440                 445             


Met Pro Arg Trp Ala Ala Glu His Arg Leu Glu Glu Lys Lys Xaa Trp 
    450                 455                 460                 


Leu Xaa Asn Gly Phe Asp Val Phe Glu Cys Pro Pro Pro Lys Xaa Glu 
465                 470                 475                 480 


Asn Glu Leu Leu Gln Met Phe Tyr Arg Gln Gln Glu Glu Ile Arg Arg 
                485                 490                 495     


Leu Arg Glu Leu Leu Xaa Gln Arg Glu Val Gln Ala Lys Gln Leu Glu 
            500                 505                 510         


Leu Glu Ile Lys Asn Leu Arg Met Gly Ser Glu Gln Leu 
        515                 520                 525 


<210> 6776
<211> 105
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<400> 6776
Met Pro Leu Ser Pro Gly Leu Leu Leu Leu Leu Leu Ser Gly Ala Xaa 
1               5                   10                  15      


Ala Xaa Ala Ala Leu Pro Leu Glu Gly Gly Pro Xaa Gly Arg Asp Ser 
            20                  25                  30          


Glu His Met Gln Glu Ala Ala Gly Ile Arg Lys Ser Ser Leu Leu Xaa 
        35                  40                  45              


Phe Leu Ala Trp Trp Phe Glu Trp Xaa Ser Gln Ala Ser Ala Gly Pro 
    50                  55                  60                  


Leu Ile Gly Glu Glu Ala Arg Glu Val Ala Arg Arg Gln Glu Gly Ala 
65                  70                  75                  80  


Pro Pro Gln Gln Ser Ala Arg Arg Asp Arg Met Pro Cys Arg Asn Phe 
                85                  90                  95      


Phe Trp Lys Xaa Phe Ser Ser Cys Lys 
            100                 105 


<210> 6777
<211> 476
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<400> 6777
Met Ala Gly Arg Gly Gly Ser Ala Leu Leu Ala Leu Cys Gly Ala Leu 
1               5                   10                  15      


Ala Ala Cys Gly Trp Leu Leu Gly Ala Glu Ala Gln Glu Pro Gly Ala 
            20                  25                  30          


Pro Ala Ala Gly Met Arg Arg Arg Arg Arg Leu Gln Gln Glu Asp Gly 
        35                  40                  45              


Ile Ser Phe Glu Tyr His Arg Tyr Pro Glu Leu Arg Glu Ala Leu Val 
    50                  55                  60                  


Ser Val Trp Leu Gln Cys Xaa Ala Ile Ser Arg Ile Tyr Xaa Val Gly 
65                  70                  75                  80  


Arg Ser Phe Glu Gly Arg Glu Leu Leu Val Ile Glu Leu Ser Asp Asn 
                85                  90                  95      


Pro Gly Val His Glu Pro Gly Glu Pro Glu Phe Lys Tyr Ile Gly Asn 
            100                 105                 110         


Met His Gly Asn Glu Ala Val Gly Arg Glu Leu Leu Ile Phe Leu Ala 
        115                 120                 125             


Gln Tyr Leu Cys Asn Glu Tyr Gln Lys Gly Asn Glu Xaa Ile Val Asn 
    130                 135                 140                 


Leu Ile His Ser Xaa Arg Ile His Ile Met Pro Ser Leu Asn Pro Asp 
145                 150                 155                 160 


Gly Phe Glu Lys Ala Ala Ser Gln Pro Gly Glu Leu Lys Asp Trp Phe 
                165                 170                 175     


Val Gly Arg Ser Asn Ala Gln Gly Ile Asp Leu Asn Arg Asn Phe Pro 
            180                 185                 190         


Asp Leu Asp Arg Ile Val Tyr Val Asn Glu Lys Glu Gly Gly Pro Asn 
        195                 200                 205             


Asn His Leu Leu Lys Asn Met Lys Lys Ile Val Asp Gln Asn Xaa Lys 
    210                 215                 220                 


Leu Ala Pro Glu Xaa Lys Ala Val Ile His Trp Ile Met Asp Ile Pro 
225                 230                 235                 240 


Phe Val Leu Ser Ala Asn Leu His Gly Gly Asp Leu Val Ala Asn Tyr 
                245                 250                 255     


Pro Tyr Asp Glu Xaa Arg Ser Gly Ser Ala His Glu Tyr Ser Ser Ser 
            260                 265                 270         


Pro Asp Asp Ala Ile Phe Gln Ser Leu Ala Arg Ala Tyr Ser Ser Phe 
        275                 280                 285             


Asn Pro Ala Met Ser Asp Pro Asn Arg Pro Pro Cys Arg Lys Asn Asp 
    290                 295                 300                 


Asp Asp Ser Ser Phe Val Asp Gly Xaa Xaa Asn Gly Gly Ala Trp Tyr 
305                 310                 315                 320 


Ser Val Pro Gly Gly Met Gln Asp Phe Asn Tyr Leu Ser Ser Asn Cys 
                325                 330                 335     


Phe Glu Ile Xaa Val Glu Leu Ser Cys Glu Lys Phe Pro Pro Glu Glu 
            340                 345                 350         


Xaa Leu Lys Xaa Tyr Trp Glu Asp Asn Lys Asn Ser Leu Ile Ser Tyr 
        355                 360                 365             


Leu Glu Gln Ile His Arg Gly Val Lys Gly Phe Val Arg Asp Leu Gln 
    370                 375                 380                 


Gly Asn Pro Ile Ala Asn Ala Xaa Ile Ser Val Glu Gly Ile Asp His 
385                 390                 395                 400 


Asp Val Xaa Ser Ala Lys Asp Gly Asp Tyr Trp Arg Leu Leu Ile Pro 
                405                 410                 415     


Gly Asn Tyr Lys Leu Xaa Ala Ser Ala Pro Gly Tyr Leu Ala Ile Xaa 
            420                 425                 430         


Lys Lys Val Ala Val Pro Tyr Ser Pro Ala Ala Gly Val Asp Phe Glu 
        435                 440                 445             


Leu Glu Ser Phe Ser Glu Arg Lys Glu Glu Glu Lys Glu Glu Leu Met 
    450                 455                 460                 


Glu Trp Trp Lys Met Met Ser Glu Xaa Leu Asn Phe 
465                 470                 475     


<210> 6778
<211> 139
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 6778
Met His Gly Asn Glu Ala Val Gly Arg Glu Leu Leu Ile Phe Leu Ala 
1               5                   10                  15      


Gln Tyr Leu Cys Asn Glu Tyr Gln Lys Gly Asn Glu Xaa Ile Val Asn 
            20                  25                  30          


Leu Ile His Ser Xaa Arg Ile His Ile Met Pro Ser Leu Asn Pro Asp 
        35                  40                  45              


Gly Phe Glu Lys Ala Ala Ser Gln Pro Gly Glu Leu Lys Asp Trp Phe 
    50                  55                  60                  


Val Gly Arg Ser Asn Ala Gln Gly Ile Asp Leu Asn Arg Asn Phe Pro 
65                  70                  75                  80  


Asp Leu Asp Arg Ile Val Tyr Val Asn Glu Lys Glu Gly Gly Pro Asn 
                85                  90                  95      


Asn His Leu Leu Lys Asn Met Lys Lys Ile Val Asp Gln Asn Xaa Lys 
            100                 105                 110         


Leu Ala Pro Glu Xaa Lys Ala Val Ile His Trp Ile Met Asp Ile Pro 
        115                 120                 125             


Phe Val Leu Ser Ala Asn Leu His Gly Gly Asp 
    130                 135                 


<210> 6779
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 6779
Met His Gly Asn Glu Ala Val Gly Arg Glu Leu Leu Ile Phe Leu Ala 
1               5                   10                  15      


Gln Tyr Leu Cys Asn Glu Tyr Gln Lys Gly Asn Glu Xaa Ile Val Asn 
            20                  25                  30          


Leu Ile His Ser Xaa Arg Ile His Ile Met Pro Ser Leu Asn Pro Asp 
        35                  40                  45              


Gly Phe Glu Lys Ala Ala Ser Gln Pro Gly Glu Leu Lys Asp Trp Phe 
    50                  55                  60                  


Val Gly Arg Ser Asn Ala Gln Gly Ile Asp Leu Asn Arg Asn Phe Pro 
65                  70                  75                  80  


Asp Leu Asp Arg Ile Val Tyr Val Asn Glu Lys Glu Gly Gly Pro Asn 
                85                  90                  95      


Asn His Leu Leu Lys Asn Met Lys Lys Ile Val Asp Gln Asn Xaa Lys 
            100                 105                 110         


Leu Ala Pro Glu Xaa Lys Ala Val Ile His Trp Ile Met Asp Ile Pro 
        115                 120                 125             


Phe Val Leu Ser Ala Asn Leu His Gly Gly Asp Leu Val Ala Asn Tyr 
    130                 135                 140                 


Pro Tyr Asp 
145         


<210> 6780
<211> 157
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<400> 6780
Met His Gly Asn Glu Ala Val Gly Arg Glu Leu Leu Ile Phe Leu Ala 
1               5                   10                  15      


Gln Tyr Leu Cys Asn Glu Tyr Gln Lys Gly Asn Glu Xaa Ile Val Asn 
            20                  25                  30          


Leu Ile His Ser Xaa Arg Ile His Ile Met Pro Ser Leu Asn Pro Asp 
        35                  40                  45              


Gly Phe Glu Lys Ala Ala Ser Gln Pro Gly Glu Leu Lys Asp Trp Phe 
    50                  55                  60                  


Val Gly Arg Ser Asn Ala Gln Gly Ile Asp Leu Asn Arg Asn Phe Pro 
65                  70                  75                  80  


Asp Leu Asp Arg Ile Val Tyr Val Asn Glu Lys Glu Gly Gly Pro Asn 
                85                  90                  95      


Asn His Leu Leu Lys Asn Met Lys Lys Ile Val Asp Gln Asn Xaa Lys 
            100                 105                 110         


Leu Ala Pro Glu Xaa Lys Ala Val Ile His Trp Ile Met Asp Ile Pro 
        115                 120                 125             


Phe Val Leu Ser Ala Asn Leu His Gly Gly Asp Leu Val Ala Asn Tyr 
    130                 135                 140                 


Pro Tyr Asp Glu Xaa Arg Ser Gly Ser Ala His Glu Tyr 
145                 150                 155         


<210> 6781
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<400> 6781
Xaa Leu Gly Ala Glu Ala Gln Glu Pro Gly Ala Pro Ala Ala Gly Met 
1               5                   10                  15      


Arg Arg Arg Arg Arg Leu Gln Gln Glu Asp Gly Ile Ser Phe Glu Tyr 
            20                  25                  30          


His Arg Tyr Pro Glu Leu Arg Glu Ala Leu Val Ser Val Trp Leu Gln 
        35                  40                  45              


Cys Xaa Ala Ile Ser Arg Ile Tyr Xaa Val Gly Arg Ser Phe Glu Gly 
    50                  55                  60                  


Arg Glu Leu Leu Val Ile Glu Leu Ser Asp Asn Pro Gly Val His Glu 
65                  70                  75                  80  


Pro Asp Cys Lys Leu Tyr Glu Val Gly Xaa Leu Ile Pro Ala Pro Ser 
                85                  90                  95      


Ser Cys Leu Ala His Ser Gly Leu Glu Tyr Xaa Leu 
            100                 105             


<210> 6782
<211> 639
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<400> 6782
Met Gly Asp Tyr Gly Phe Gly Val Leu Val Gln Ser Asn Xaa Gly Asn 
1               5                   10                  15      


Lys Ser Ala Phe Pro Val Arg Phe His Pro His Leu Gln Pro Pro His 
            20                  25                  30          


His His Gln Asn Ala Xaa Pro Ser Pro Ala Ala Phe Ile Asn Asn Asn 
        35                  40                  45              


Xaa Ala Ala Asn Gly Ser Ser Ala Gly Ser Ala Trp Leu Phe Pro Ala 
    50                  55                  60                  


Pro Ala Xaa His Asn Ile Gln Asp Glu Ile Leu Gly Ser Glu Lys Ala 
65                  70                  75                  80  


Lys Ser Gln Gln Gln Glu Gln Gln Asp Pro Leu Glu Lys Gln Gln Leu 
                85                  90                  95      


Ser Pro Ser Pro Gly Gln Glu Ala Gly Ile Leu Pro Glu Xaa Glu Lys 
            100                 105                 110         


Ala Lys Ser Glu Glu Asn Gln Gly Asp Asn Ser Ser Glu Asn Gly Asn 
        115                 120                 125             


Gly Lys Glu Lys Ile Arg Ile Glu Ser Pro Val Leu Xaa Gly Phe Asp 
    130                 135                 140                 


Tyr Gln Glu Ala Xaa Gly Leu Gly Xaa Ser Xaa Gln Pro Leu Xaa Ser 
145                 150                 155                 160 


Ser Ala Ser Ser Leu Xaa Gly Phe Ser Asn Trp Ser Ala Ala Ile Ala 
                165                 170                 175     


Pro Ser Ser Ser Xaa Ile Ile Asn Glu Asp Ala Ser Phe Phe His Gln 
            180                 185                 190         


Gly Gly Val Pro Ala Ala Ser Ala Asn Asn Gly Ala Leu Leu Phe Gln 
        195                 200                 205             


Asn Phe Pro His His Val Ser Pro Gly Phe Gly Gly Ser Phe Ser Pro 
    210                 215                 220                 


Gln Ile Gly Pro Leu Ser Gln His His Pro His His Pro His Phe Gln 
225                 230                 235                 240 


His His His Ser Gln His Gln Gln Gln Arg Arg Ser Pro Ala Ser Pro 
                245                 250                 255     


His Pro Pro Pro Phe Xaa His Arg Asn Ala Ala Phe Asn Gln Leu Pro 
            260                 265                 270         


His Leu Ala Asn Asn Leu Asn Lys Pro Pro Ser Pro Trp Ser Ser Tyr 
        275                 280                 285             


Gln Ser Pro Ser Pro Xaa Pro Ser Ser Ser Trp Ser Pro Gly Gly Gly 
    290                 295                 300                 


Gly Tyr Gly Gly Trp Gly Gly Ser Gln Gly Arg Asp His Arg Arg Gly 
305                 310                 315                 320 


Leu Asn Gly Gly Ile Xaa Pro Leu Asn Ser Ile Ser Pro Leu Lys Lys 
                325                 330                 335     


Asn Phe Ala Ser Asn His Ile Gln Leu Gln Lys Tyr Ala Arg Pro Ser 
            340                 345                 350         


Ser Ala Phe Ala Pro Lys Ser Trp Met Glu Asp Ser Leu Asn Arg Ala 
        355                 360                 365             


Asp Asn Ile Phe Pro Phe Pro Asp Arg Pro Arg Xaa Phe Asp Met His 
    370                 375                 380                 


Ser Leu Glu Ser Ser Leu Ile Asp Ile Met Arg Ala Glu Asn Asp Xaa 
385                 390                 395                 400 


Ile Lys Gly Gln Ser Ser Leu Phe Pro Met Glu Asp Gly Phe Leu Asp 
                405                 410                 415     


Asp Gly Arg Gly Asp Gln Pro Leu His Ser Gly Leu Gly Ser Pro His 
            420                 425                 430         


Cys Phe Ser His Gln Asn Gly Glu Arg Val Glu Arg Tyr Ser Arg Lys 
        435                 440                 445             


Val Phe Val Gly Gly Leu Pro Pro Asp Ile Asp Glu Asp Glu Ile Xaa 
    450                 455                 460                 


Ala Ser Phe Arg Arg Phe Gly Pro Leu Ile Val Asp Trp Pro His Lys 
465                 470                 475                 480 


Ala Glu Ser Lys Ser Tyr Phe Pro Pro Lys Gly Tyr Ala Phe Leu Leu 
                485                 490                 495     


Phe Gln Asp Glu Ser Ser Val Gln Ala Leu Ile Asp Ala Cys Ile Glu 
            500                 505                 510         


Glu Asp Gly Lys Leu Tyr Leu Cys Val Ser Ser Pro Xaa Ile Lys Asp 
        515                 520                 525             


Lys Pro Val Gln Ile Arg Pro Trp Asn Leu Ser Asp Ser Asp Phe Val 
    530                 535                 540                 


Met Asp Gly Ser Gln Pro Leu Asp Pro Arg Lys Xaa Ile Phe Val Gly 
545                 550                 555                 560 


Gly Val Pro Arg Pro Leu Arg Ala Val Glu Leu Ala Met Ile Met Asp 
                565                 570                 575     


Arg Leu Tyr Gly Gly Val Cys Tyr Ala Gly Ile Asp Xaa Asp Pro Glu 
            580                 585                 590         


Leu Lys Tyr Pro Lys Gly Ala Gly Arg Val Ala Phe Ser Asn Gln Gln 
        595                 600                 605             


Ser Tyr Ile Ala Ala Ile Ser Ala Arg Phe Val Gln Leu Gln His Gly 
    610                 615                 620                 


Glu Ile Asp Lys Arg Val Ser Leu Ile Leu His Phe Gly Lys Phe 
625                 630                 635                 


<210> 6783
<211> 704
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<400> 6783
Met Gly Asp Tyr Gly Phe Gly Val Leu Val Gln Ser Asn Xaa Gly Asn 
1               5                   10                  15      


Lys Ser Ala Phe Pro Val Arg Phe His Pro His Leu Gln Pro Pro His 
            20                  25                  30          


His His Gln Asn Ala Xaa Pro Ser Pro Ala Ala Phe Ile Asn Asn Asn 
        35                  40                  45              


Xaa Ala Ala Asn Gly Ser Ser Ala Gly Ser Ala Trp Leu Phe Pro Ala 
    50                  55                  60                  


Pro Ala Xaa His Asn Ile Gln Asp Glu Ile Leu Gly Ser Glu Lys Ala 
65                  70                  75                  80  


Lys Ser Gln Gln Gln Glu Gln Gln Asp Pro Leu Glu Lys Gln Gln Leu 
                85                  90                  95      


Ser Pro Ser Pro Gly Gln Glu Ala Gly Ile Leu Pro Glu Xaa Glu Lys 
            100                 105                 110         


Ala Lys Ser Glu Glu Asn Gln Gly Asp Asn Ser Ser Glu Asn Gly Asn 
        115                 120                 125             


Gly Lys Glu Lys Ile Arg Ile Glu Ser Pro Val Leu Xaa Gly Phe Asp 
    130                 135                 140                 


Tyr Gln Glu Ala Xaa Gly Leu Gly Xaa Ser Xaa Gln Pro Leu Xaa Ser 
145                 150                 155                 160 


Ser Ala Ser Ser Leu Xaa Gly Phe Ser Asn Trp Ser Ala Ala Ile Ala 
                165                 170                 175     


Pro Ser Ser Ser Xaa Ile Ile Asn Glu Asp Ala Ser Phe Phe His Gln 
            180                 185                 190         


Gly Gly Val Pro Ala Ala Ser Ala Asn Asn Gly Ala Leu Leu Phe Gln 
        195                 200                 205             


Asn Phe Pro His His Val Ser Pro Gly Phe Gly Gly Ser Phe Ser Pro 
    210                 215                 220                 


Gln Ile Gly Pro Leu Ser Gln His His Pro His His Pro His Phe Gln 
225                 230                 235                 240 


His His His Ser Gln His Gln Gln Gln Arg Arg Ser Pro Ala Ser Pro 
                245                 250                 255     


His Pro Pro Pro Phe Xaa His Arg Asn Ala Ala Phe Asn Gln Leu Pro 
            260                 265                 270         


His Leu Ala Asn Asn Leu Asn Lys Pro Pro Ser Pro Trp Ser Ser Tyr 
        275                 280                 285             


Gln Ser Pro Ser Pro Xaa Pro Ser Ser Ser Trp Ser Pro Gly Gly Gly 
    290                 295                 300                 


Gly Tyr Gly Gly Trp Gly Gly Ser Gln Gly Arg Asp His Arg Arg Gly 
305                 310                 315                 320 


Leu Asn Gly Gly Ile Xaa Pro Leu Asn Ser Ile Ser Pro Leu Lys Lys 
                325                 330                 335     


Asn Phe Ala Ser Asn His Ile Gln Leu Gln Lys Tyr Ala Arg Pro Ser 
            340                 345                 350         


Ser Ala Phe Ala Pro Lys Ser Trp Met Glu Asp Ser Leu Asn Arg Ala 
        355                 360                 365             


Asp Asn Ile Phe Pro Phe Pro Asp Arg Pro Arg Xaa Phe Asp Met His 
    370                 375                 380                 


Ser Leu Glu Ser Ser Leu Ile Asp Ile Met Arg Ala Glu Asn Asp Xaa 
385                 390                 395                 400 


Ile Lys Gly Gln Ser Ser Leu Phe Pro Met Glu Asp Gly Phe Leu Asp 
                405                 410                 415     


Asp Gly Arg Gly Asp Gln Pro Leu His Ser Gly Leu Gly Ser Pro His 
            420                 425                 430         


Cys Phe Ser His Gln Asn Gly Glu Arg Val Glu Arg Tyr Ser Arg Lys 
        435                 440                 445             


Val Phe Val Gly Gly Leu Pro Pro Asp Ile Asp Glu Asp Glu Ile Xaa 
    450                 455                 460                 


Ala Ser Phe Arg Arg Phe Gly Pro Leu Ile Val Asp Trp Pro His Lys 
465                 470                 475                 480 


Ala Glu Ser Lys Ser Tyr Phe Pro Pro Lys Gly Tyr Ala Phe Leu Leu 
                485                 490                 495     


Phe Gln Asp Glu Ser Ser Val Gln Ala Leu Ile Asp Ala Cys Ile Glu 
            500                 505                 510         


Glu Asp Gly Lys Leu Tyr Leu Cys Val Ser Ser Pro Xaa Ile Lys Asp 
        515                 520                 525             


Lys Pro Val Gln Ile Arg Pro Trp Asn Leu Ser Asp Ser Asp Phe Val 
    530                 535                 540                 


Met Asp Gly Ser Gln Pro Leu Asp Pro Arg Lys Xaa Ile Phe Val Gly 
545                 550                 555                 560 


Gly Val Pro Arg Pro Leu Arg Ala Val Glu Leu Ala Met Ile Met Asp 
                565                 570                 575     


Arg Leu Tyr Gly Gly Val Cys Tyr Ala Gly Ile Asp Xaa Asp Pro Glu 
            580                 585                 590         


Leu Lys Tyr Pro Lys Gly Ala Gly Arg Val Ala Phe Ser Asn Gln Gln 
        595                 600                 605             


Ser Tyr Ile Ala Ala Ile Ser Ala Arg Phe Val Gln Leu Gln His Gly 
    610                 615                 620                 


Glu Ile Asp Lys Arg Val Glu Val Lys Pro Tyr Val Leu Asp Asp Gln 
625                 630                 635                 640 


Leu Cys Asp Glu Cys Gln Gly Ala Arg Cys Gly Gly Lys Phe Ala Pro 
                645                 650                 655     


Phe Phe Cys Ala Asn Val Xaa Cys Leu Gln Tyr Tyr Cys Glu Tyr Cys 
            660                 665                 670         


Trp Ala Ala Ile His Ser Arg Ala Gly Arg Glu Phe His Lys Pro Leu 
        675                 680                 685             


Val Lys Glu Gly Gly Asp Arg Pro Arg His Ile Ser Phe Arg Trp Asn 
    690                 695                 700                 


<210> 6784
<211> 712
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<400> 6784
Met Gly Asp Tyr Gly Phe Gly Val Leu Val Gln Ser Asn Xaa Gly Asn 
1               5                   10                  15      


Lys Ser Ala Phe Pro Val Arg Phe His Pro His Leu Gln Pro Pro His 
            20                  25                  30          


His His Gln Asn Ala Xaa Pro Ser Pro Ala Ala Phe Ile Asn Asn Asn 
        35                  40                  45              


Xaa Ala Ala Asn Gly Ser Ser Ala Gly Ser Ala Trp Leu Phe Pro Ala 
    50                  55                  60                  


Pro Ala Xaa His Asn Ile Gln Asp Glu Ile Leu Gly Ser Glu Lys Ala 
65                  70                  75                  80  


Lys Ser Gln Gln Gln Glu Gln Gln Asp Pro Leu Glu Lys Gln Gln Leu 
                85                  90                  95      


Ser Pro Ser Pro Gly Gln Glu Ala Gly Ile Leu Pro Glu Xaa Glu Lys 
            100                 105                 110         


Ala Lys Ser Glu Glu Asn Gln Gly Asp Asn Ser Ser Glu Asn Gly Asn 
        115                 120                 125             


Gly Lys Glu Lys Ile Arg Ile Glu Ser Pro Val Leu Xaa Gly Phe Asp 
    130                 135                 140                 


Tyr Gln Glu Ala Xaa Gly Leu Gly Xaa Ser Xaa Gln Pro Leu Xaa Ser 
145                 150                 155                 160 


Ser Ala Ser Ser Leu Xaa Gly Phe Ser Asn Trp Ser Ala Ala Ile Ala 
                165                 170                 175     


Pro Ser Ser Ser Xaa Ile Ile Asn Glu Asp Ala Ser Phe Phe His Gln 
            180                 185                 190         


Gly Gly Val Pro Ala Ala Ser Ala Asn Asn Gly Ala Leu Leu Phe Gln 
        195                 200                 205             


Asn Phe Pro His His Val Ser Pro Gly Phe Gly Gly Ser Phe Ser Pro 
    210                 215                 220                 


Gln Ile Gly Pro Leu Ser Gln His His Pro His His Pro His Phe Gln 
225                 230                 235                 240 


His His His Ser Gln His Gln Gln Gln Arg Arg Ser Pro Ala Ser Pro 
                245                 250                 255     


His Pro Pro Pro Phe Xaa His Arg Asn Ala Ala Phe Asn Gln Leu Pro 
            260                 265                 270         


His Leu Ala Asn Asn Leu Asn Lys Pro Pro Ser Pro Trp Ser Ser Tyr 
        275                 280                 285             


Gln Ser Pro Ser Pro Xaa Pro Ser Ser Ser Trp Ser Pro Gly Gly Gly 
    290                 295                 300                 


Gly Tyr Gly Gly Trp Gly Gly Ser Gln Gly Arg Asp His Arg Arg Gly 
305                 310                 315                 320 


Leu Asn Gly Gly Ile Xaa Pro Leu Asn Ser Ile Ser Pro Leu Lys Lys 
                325                 330                 335     


Asn Phe Ala Ser Asn His Ile Gln Leu Gln Lys Tyr Ala Arg Pro Ser 
            340                 345                 350         


Ser Ala Phe Ala Pro Lys Ser Trp Met Glu Asp Ser Leu Asn Arg Ala 
        355                 360                 365             


Asp Asn Ile Phe Pro Phe Pro Asp Arg Pro Arg Xaa Phe Asp Met His 
    370                 375                 380                 


Ser Leu Glu Ser Ser Leu Ile Asp Ile Met Arg Ala Glu Asn Asp Xaa 
385                 390                 395                 400 


Ile Lys Ala Arg Xaa Tyr Gly Arg Arg Arg Gly Gln Ser Ser Leu Phe 
                405                 410                 415     


Pro Met Glu Asp Gly Phe Leu Asp Asp Gly Arg Gly Asp Gln Pro Leu 
            420                 425                 430         


His Ser Gly Leu Gly Ser Pro His Cys Phe Ser His Gln Asn Gly Glu 
        435                 440                 445             


Arg Val Glu Arg Tyr Ser Arg Lys Val Phe Val Gly Gly Leu Pro Pro 
    450                 455                 460                 


Asp Ile Asp Glu Asp Glu Ile Xaa Ala Ser Phe Arg Arg Phe Gly Pro 
465                 470                 475                 480 


Leu Ile Val Asp Trp Pro His Lys Ala Glu Ser Lys Ser Tyr Phe Pro 
                485                 490                 495     


Pro Lys Gly Tyr Ala Phe Leu Leu Phe Gln Asp Glu Ser Ser Val Gln 
            500                 505                 510         


Ala Leu Ile Asp Ala Cys Ile Glu Glu Asp Gly Lys Leu Tyr Leu Cys 
        515                 520                 525             


Val Ser Ser Pro Xaa Ile Lys Asp Lys Pro Val Gln Ile Arg Pro Trp 
    530                 535                 540                 


Asn Leu Ser Asp Ser Asp Phe Val Met Asp Gly Ser Gln Pro Leu Asp 
545                 550                 555                 560 


Pro Arg Lys Xaa Ile Phe Val Gly Gly Val Pro Arg Pro Leu Arg Ala 
                565                 570                 575     


Val Glu Leu Ala Met Ile Met Asp Arg Leu Tyr Gly Gly Val Cys Tyr 
            580                 585                 590         


Ala Gly Ile Asp Xaa Asp Pro Glu Leu Lys Tyr Pro Lys Gly Ala Gly 
        595                 600                 605             


Arg Val Ala Phe Ser Asn Gln Gln Ser Tyr Ile Ala Ala Ile Ser Ala 
    610                 615                 620                 


Arg Phe Val Gln Leu Gln His Gly Glu Ile Asp Lys Arg Val Glu Val 
625                 630                 635                 640 


Lys Pro Tyr Val Leu Asp Asp Gln Leu Cys Asp Glu Cys Gln Gly Ala 
                645                 650                 655     


Arg Cys Gly Gly Lys Phe Ala Pro Phe Phe Cys Ala Asn Val Xaa Cys 
            660                 665                 670         


Leu Gln Tyr Tyr Cys Glu Tyr Cys Trp Ala Ala Ile His Ser Arg Ala 
        675                 680                 685             


Gly Arg Glu Phe His Lys Pro Leu Val Lys Glu Gly Gly Asp Arg Pro 
    690                 695                 700                 


Arg His Ile Ser Phe Arg Trp Asn 
705                 710         


<210> 6785
<211> 729
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<400> 6785
Met Gly Asp Tyr Gly Phe Gly Val Leu Val Gln Ser Asn Xaa Gly Asn 
1               5                   10                  15      


Lys Ser Ala Phe Pro Val Arg Phe His Pro His Leu Gln Pro Pro His 
            20                  25                  30          


His His Gln Asn Ala Xaa Pro Ser Pro Ala Ala Phe Ile Asn Asn Asn 
        35                  40                  45              


Xaa Ala Ala Asn Gly Ser Ser Ala Gly Ser Ala Trp Leu Phe Pro Ala 
    50                  55                  60                  


Pro Ala Xaa His Asn Ile Gln Asp Glu Ile Leu Gly Ser Glu Lys Ala 
65                  70                  75                  80  


Lys Ser Gln Gln Gln Glu Gln Gln Asp Pro Leu Glu Lys Gln Gln Leu 
                85                  90                  95      


Ser Pro Ser Pro Gly Gln Glu Ala Gly Ile Leu Pro Glu Xaa Glu Lys 
            100                 105                 110         


Ala Lys Ser Glu Glu Asn Gln Gly Asp Asn Ser Ser Glu Asn Gly Asn 
        115                 120                 125             


Gly Lys Glu Lys Ile Arg Ile Glu Ser Pro Val Leu Xaa Gly Phe Asp 
    130                 135                 140                 


Tyr Gln Glu Ala Xaa Gly Leu Gly Xaa Ser Xaa Gln Pro Leu Xaa Ser 
145                 150                 155                 160 


Ser Ala Ser Ser Leu Xaa Gly Phe Ser Asn Trp Ser Ala Ala Ile Ala 
                165                 170                 175     


Pro Ser Ser Ser Xaa Ile Ile Asn Glu Asp Ala Ser Phe Phe His Gln 
            180                 185                 190         


Gly Gly Val Pro Ala Ala Ser Ala Asn Asn Gly Ala Leu Leu Phe Gln 
        195                 200                 205             


Asn Phe Pro His His Val Ser Pro Gly Phe Gly Gly Ser Phe Ser Pro 
    210                 215                 220                 


Gln Ile Gly Pro Leu Ser Gln His His Pro His His Pro His Phe Gln 
225                 230                 235                 240 


His His His Ser Gln His Gln Gln Gln Arg Arg Ser Pro Ala Ser Pro 
                245                 250                 255     


His Pro Pro Pro Phe Xaa His Arg Asn Ala Ala Phe Asn Gln Leu Pro 
            260                 265                 270         


His Leu Ala Asn Asn Leu Asn Lys Pro Pro Ser Pro Trp Ser Ser Tyr 
        275                 280                 285             


Gln Ser Pro Ser Pro Xaa Pro Ser Ser Ser Trp Ser Pro Gly Gly Gly 
    290                 295                 300                 


Gly Tyr Gly Gly Trp Gly Gly Ser Gln Gly Arg Asp His Arg Arg Gly 
305                 310                 315                 320 


Leu Asn Gly Gly Ile Xaa Pro Leu Asn Ser Ile Ser Pro Leu Lys Lys 
                325                 330                 335     


Asn Phe Ala Ser Asn His Ile Gln Leu Gln Lys Tyr Ala Arg Pro Ser 
            340                 345                 350         


Ser Ala Phe Ala Pro Lys Ser Trp Met Glu Asp Ser Leu Asn Arg Ala 
        355                 360                 365             


Asp Asn Ile Phe Pro Phe Pro Asp Arg Pro Arg Xaa Phe Asp Met His 
    370                 375                 380                 


Ser Leu Glu Ser Ser Leu Ile Asp Ile Met Arg Ala Glu Asn Asp Xaa 
385                 390                 395                 400 


Ile Lys Gly Arg Leu Asn Tyr Ser Tyr Pro Gly Ser Asp Ser Ser Leu 
                405                 410                 415     


Leu Ile Asn Ala Arg Xaa Tyr Gly Arg Arg Arg Gly Gln Ser Ser Leu 
            420                 425                 430         


Phe Pro Met Glu Asp Gly Phe Leu Asp Asp Gly Arg Gly Asp Gln Pro 
        435                 440                 445             


Leu His Ser Gly Leu Gly Ser Pro His Cys Phe Ser His Gln Asn Gly 
    450                 455                 460                 


Glu Arg Val Glu Arg Tyr Ser Arg Lys Val Phe Val Gly Gly Leu Pro 
465                 470                 475                 480 


Pro Asp Ile Asp Glu Asp Glu Ile Xaa Ala Ser Phe Arg Arg Phe Gly 
                485                 490                 495     


Pro Leu Ile Val Asp Trp Pro His Lys Ala Glu Ser Lys Ser Tyr Phe 
            500                 505                 510         


Pro Pro Lys Gly Tyr Ala Phe Leu Leu Phe Gln Asp Glu Ser Ser Val 
        515                 520                 525             


Gln Ala Leu Ile Asp Ala Cys Ile Glu Glu Asp Gly Lys Leu Tyr Leu 
    530                 535                 540                 


Cys Val Ser Ser Pro Xaa Ile Lys Asp Lys Pro Val Gln Ile Arg Pro 
545                 550                 555                 560 


Trp Asn Leu Ser Asp Ser Asp Phe Val Met Asp Gly Ser Gln Pro Leu 
                565                 570                 575     


Asp Pro Arg Lys Xaa Ile Phe Val Gly Gly Val Pro Arg Pro Leu Arg 
            580                 585                 590         


Ala Val Glu Leu Ala Met Ile Met Asp Arg Leu Tyr Gly Gly Val Cys 
        595                 600                 605             


Tyr Ala Gly Ile Asp Xaa Asp Pro Glu Leu Lys Tyr Pro Lys Gly Ala 
    610                 615                 620                 


Gly Arg Val Ala Phe Ser Asn Gln Gln Ser Tyr Ile Ala Ala Ile Ser 
625                 630                 635                 640 


Ala Arg Phe Val Gln Leu Gln His Gly Glu Ile Asp Lys Arg Val Glu 
                645                 650                 655     


Val Lys Pro Tyr Val Leu Asp Asp Gln Leu Cys Asp Glu Cys Gln Gly 
            660                 665                 670         


Ala Arg Cys Gly Gly Lys Phe Ala Pro Phe Phe Cys Ala Asn Val Xaa 
        675                 680                 685             


Cys Leu Gln Tyr Tyr Cys Glu Tyr Cys Trp Ala Ala Ile His Ser Arg 
    690                 695                 700                 


Ala Gly Arg Glu Phe His Lys Pro Leu Val Lys Glu Gly Gly Asp Arg 
705                 710                 715                 720 


Pro Arg His Ile Ser Phe Arg Trp Asn 
                725                 


<210> 6786
<211> 322
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<400> 6786
Met His Ser Leu Glu Ser Ser Leu Ile Asp Ile Met Arg Ala Glu Asn 
1               5                   10                  15      


Asp Xaa Ile Lys Gly Gln Ser Ser Leu Phe Pro Met Glu Asp Gly Phe 
            20                  25                  30          


Leu Asp Asp Gly Arg Gly Asp Gln Pro Leu His Ser Gly Leu Gly Ser 
        35                  40                  45              


Pro His Cys Phe Ser His Gln Asn Gly Glu Arg Val Glu Arg Tyr Ser 
    50                  55                  60                  


Arg Lys Val Phe Val Gly Gly Leu Pro Pro Asp Ile Asp Glu Asp Glu 
65                  70                  75                  80  


Ile Xaa Ala Ser Phe Arg Arg Phe Gly Pro Leu Ile Val Asp Trp Pro 
                85                  90                  95      


His Lys Ala Glu Ser Lys Ser Tyr Phe Pro Pro Lys Gly Tyr Ala Phe 
            100                 105                 110         


Leu Leu Phe Gln Asp Glu Ser Ser Val Gln Ala Leu Ile Asp Ala Cys 
        115                 120                 125             


Ile Glu Glu Asp Gly Lys Leu Tyr Leu Cys Val Ser Ser Pro Xaa Ile 
    130                 135                 140                 


Lys Asp Lys Pro Val Gln Ile Arg Pro Trp Asn Leu Ser Asp Ser Asp 
145                 150                 155                 160 


Phe Val Met Asp Gly Ser Gln Pro Leu Asp Pro Arg Lys Xaa Ile Phe 
                165                 170                 175     


Val Gly Gly Val Pro Arg Pro Leu Arg Ala Val Glu Leu Ala Met Ile 
            180                 185                 190         


Met Asp Arg Leu Tyr Gly Gly Val Cys Tyr Ala Gly Ile Asp Xaa Asp 
        195                 200                 205             


Pro Glu Leu Lys Tyr Pro Lys Gly Ala Gly Arg Val Ala Phe Ser Asn 
    210                 215                 220                 


Gln Gln Ser Tyr Ile Ala Ala Ile Ser Ala Arg Phe Val Gln Leu Gln 
225                 230                 235                 240 


His Gly Glu Ile Asp Lys Arg Val Glu Val Lys Pro Tyr Val Leu Asp 
                245                 250                 255     


Asp Gln Leu Cys Asp Glu Cys Gln Gly Ala Arg Cys Gly Gly Lys Phe 
            260                 265                 270         


Ala Pro Phe Phe Cys Ala Asn Val Xaa Cys Leu Gln Tyr Tyr Cys Glu 
        275                 280                 285             


Tyr Cys Trp Ala Ala Ile His Ser Arg Ala Gly Arg Glu Phe His Lys 
    290                 295                 300                 


Pro Leu Val Lys Glu Gly Gly Asp Arg Pro Arg His Ile Ser Phe Arg 
305                 310                 315                 320 


Trp Asn 
        


<210> 6787
<211> 339
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<400> 6787
Met His Ser Leu Glu Ser Ser Leu Ile Asp Ile Met Arg Ala Glu Asn 
1               5                   10                  15      


Asp Xaa Ile Lys Gly Arg Leu Asn Tyr Ser Tyr Pro Gly Ser Asp Ser 
            20                  25                  30          


Ser Leu Leu Ile Asn Gly Gln Ser Ser Leu Phe Pro Met Glu Asp Gly 
        35                  40                  45              


Phe Leu Asp Asp Gly Arg Gly Asp Gln Pro Leu His Ser Gly Leu Gly 
    50                  55                  60                  


Ser Pro His Cys Phe Ser His Gln Asn Gly Glu Arg Val Glu Arg Tyr 
65                  70                  75                  80  


Ser Arg Lys Val Phe Val Gly Gly Leu Pro Pro Asp Ile Asp Glu Asp 
                85                  90                  95      


Glu Ile Xaa Ala Ser Phe Arg Arg Phe Gly Pro Leu Ile Val Asp Trp 
            100                 105                 110         


Pro His Lys Ala Glu Ser Lys Ser Tyr Phe Pro Pro Lys Gly Tyr Ala 
        115                 120                 125             


Phe Leu Leu Phe Gln Asp Glu Ser Ser Val Gln Ala Leu Ile Asp Ala 
    130                 135                 140                 


Cys Ile Glu Glu Asp Gly Lys Leu Tyr Leu Cys Val Ser Ser Pro Xaa 
145                 150                 155                 160 


Ile Lys Asp Lys Pro Val Gln Ile Arg Pro Trp Asn Leu Ser Asp Ser 
                165                 170                 175     


Asp Phe Val Met Asp Gly Ser Gln Pro Leu Asp Pro Arg Lys Xaa Ile 
            180                 185                 190         


Phe Val Gly Gly Val Pro Arg Pro Leu Arg Ala Val Glu Leu Ala Met 
        195                 200                 205             


Ile Met Asp Arg Leu Tyr Gly Gly Val Cys Tyr Ala Gly Ile Asp Xaa 
    210                 215                 220                 


Asp Pro Glu Leu Lys Tyr Pro Lys Gly Ala Gly Arg Val Ala Phe Ser 
225                 230                 235                 240 


Asn Gln Gln Ser Tyr Ile Ala Ala Ile Ser Ala Arg Phe Val Gln Leu 
                245                 250                 255     


Gln His Gly Glu Ile Asp Lys Arg Val Glu Val Lys Pro Tyr Val Leu 
            260                 265                 270         


Asp Asp Gln Leu Cys Asp Glu Cys Gln Gly Ala Arg Cys Gly Gly Lys 
        275                 280                 285             


Phe Ala Pro Phe Phe Cys Ala Asn Val Xaa Cys Leu Gln Tyr Tyr Cys 
    290                 295                 300                 


Glu Tyr Cys Trp Ala Ala Ile His Ser Arg Ala Gly Arg Glu Phe His 
305                 310                 315                 320 


Lys Pro Leu Val Lys Glu Gly Gly Asp Arg Pro Arg His Ile Ser Phe 
                325                 330                 335     


Arg Trp Asn 
            


<210> 6788
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 6788
Xaa Asp His Arg Arg Gly Leu Asn Gly Gly Ile Xaa Pro Leu Asn Ser 
1               5                   10                  15      


Ile Ser Pro Leu Lys Lys Asn Phe Ala Ser Asn His Ile Gln Leu Gln 
            20                  25                  30          


Lys Tyr Ala Arg Pro Ser Ser Ala Phe Ala Pro Lys Ser Trp Met Glu 
        35                  40                  45              


Asp Ser Leu Asn Arg Ala Asp Asn Ile Phe Pro Phe Pro Asp Arg Pro 
    50                  55                  60                  


Arg Xaa Phe Asp Met His Ser Leu Glu Ser Ser Leu Ile Asp Ile Met 
65                  70                  75                  80  


Arg Ala Glu Asn Asp Xaa Ile Lys Gly Arg Leu Asn Tyr Ser Tyr Pro 
                85                  90                  95      


Gly Ser Asp Ser Ser Leu Leu Ile Asn Gly Gln Ser Ser Leu Phe Pro 
            100                 105                 110         


Met Glu Asp Gly Phe Leu Asp Asp Gly Arg Gly Asp Gln Pro Leu His 
        115                 120                 125             


Ser Gly Leu Gly Ser Pro His Cys Phe Ser His Gln Asn Gly Glu Arg 
    130                 135                 140                 


Val Glu Arg 
145         


<210> 6789
<211> 67
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<400> 6789
Met Ala His Cys Val Xaa Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15      


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30          


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Xaa Glu 
        35                  40                  45              


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Xaa Leu Gln Leu 
    50                  55                  60                  


Glu Tyr Arg 
65          


<210> 6790
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 6790
Met Ala His Cys Val Xaa Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15      


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30          


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Xaa Glu 
        35                  40                  45              


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Xaa Leu Gln Leu 
    50                  55                  60                  


Glu Tyr Arg Phe Glu Xaa Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80  


Ile Asp Asn Lys Xaa Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95      


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Xaa Leu 
            100                 105                 110         


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Xaa Ile Xaa 
        115                 120                 125             


Asp Phe Leu Gly Lys Ser Asp Pro Phe Leu 
    130                 135             


<210> 6791
<211> 213
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<400> 6791
Met Ala His Cys Val Xaa Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15      


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30          


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Xaa Glu 
        35                  40                  45              


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Xaa Leu Gln Leu 
    50                  55                  60                  


Glu Tyr Arg Phe Glu Xaa Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80  


Ile Asp Asn Lys Xaa Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95      


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Xaa Leu 
            100                 105                 110         


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Xaa Ile Xaa 
        115                 120                 125             


Asp Phe Leu Gly Lys Ser Asp Pro Phe Leu Glu Phe Phe Arg Gln Gly 
    130                 135                 140                 


Asp Gly Lys Trp His Leu Val Tyr Arg Ser Glu Val Ile Lys Asn Asn 
145                 150                 155                 160 


Leu Asn Pro Xaa Trp Lys Arg Phe Ser Val Pro Val Gln His Phe Cys 
                165                 170                 175     


Gly Gly Asn Pro Ser Xaa Pro Ile Gln Val Gln Cys Ser Asp Tyr Asp 
            180                 185                 190         


Ser Asp Gly Ser His Asp Leu Ile Gly Xaa Phe His Xaa Ser Leu Ala 
        195                 200                 205             


Gln Leu Gln Ala Val 
    210             


<210> 6792
<211> 305
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<400> 6792
Met Ala His Cys Val Xaa Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15      


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30          


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Xaa Glu 
        35                  40                  45              


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Xaa Leu Gln Leu 
    50                  55                  60                  


Glu Tyr Arg Phe Glu Xaa Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80  


Ile Asp Asn Lys Xaa Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95      


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Xaa Leu 
            100                 105                 110         


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Xaa Ile Xaa 
        115                 120                 125             


Asp Phe Leu Gly Lys Ser Asp Pro Phe Leu Glu Phe Phe Arg Gln Gly 
    130                 135                 140                 


Asp Gly Lys Trp His Leu Val Tyr Arg Ser Glu Val Ile Lys Asn Asn 
145                 150                 155                 160 


Leu Asn Pro Xaa Trp Lys Arg Phe Ser Val Pro Val Gln His Phe Cys 
                165                 170                 175     


Gly Gly Asn Pro Ser Xaa Pro Ile Gln Val Gln Cys Ser Asp Tyr Asp 
            180                 185                 190         


Ser Asp Gly Ser His Asp Leu Ile Gly Xaa Phe His Xaa Ser Leu Ala 
        195                 200                 205             


Gln Leu Gln Ala Val Pro Ala Glu Phe Glu Cys Ile His Pro Glu Lys 
    210                 215                 220                 


Gln Gln Lys Lys Lys Ser Tyr Lys Asn Ser Gly Xaa Ile Arg Val Lys 
225                 230                 235                 240 


Ile Cys Arg Val Glu Xaa Glu Tyr Ser Phe Leu Asp Tyr Val Met Gly 
                245                 250                 255     


Gly Cys Gln Ile Asn Phe Xaa Val Gly Val Asp Phe Xaa Gly Ser Asn 
            260                 265                 270         


Gly Asp Pro Ser Ser Pro Asp Ser Leu His Tyr Leu Ser Pro Xaa Gly 
        275                 280                 285             


Val Asn Glu Tyr Leu Met Ala Leu Trp Ser Val Gly Ser Val Val Gln 
    290                 295                 300                 


Asp 
305 


<210> 6793
<211> 386
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<400> 6793
Met Ala His Cys Val Xaa Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15      


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30          


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Xaa Glu 
        35                  40                  45              


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Xaa Leu Gln Leu 
    50                  55                  60                  


Glu Tyr Arg Phe Glu Xaa Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80  


Ile Asp Asn Lys Xaa Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95      


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Xaa Leu 
            100                 105                 110         


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Xaa Ile Xaa 
        115                 120                 125             


Asp Phe Leu Gly Lys Ser Asp Pro Phe Leu Glu Phe Phe Arg Gln Gly 
    130                 135                 140                 


Asp Gly Lys Trp His Leu Val Tyr Arg Ser Glu Val Ile Lys Asn Asn 
145                 150                 155                 160 


Leu Asn Pro Xaa Trp Lys Arg Phe Ser Val Pro Val Gln His Phe Cys 
                165                 170                 175     


Gly Gly Asn Pro Ser Xaa Pro Ile Gln Val Gln Cys Ser Asp Tyr Asp 
            180                 185                 190         


Ser Asp Gly Ser His Asp Leu Ile Gly Xaa Phe His Xaa Ser Leu Ala 
        195                 200                 205             


Gln Leu Gln Ala Val Pro Ala Glu Phe Glu Cys Ile His Pro Glu Lys 
    210                 215                 220                 


Gln Gln Lys Lys Lys Ser Tyr Lys Asn Ser Gly Xaa Ile Arg Val Lys 
225                 230                 235                 240 


Ile Cys Arg Val Glu Xaa Glu Tyr Ser Phe Leu Asp Tyr Val Met Gly 
                245                 250                 255     


Gly Cys Gln Ile Asn Phe Xaa Val Gly Val Asp Phe Xaa Gly Ser Asn 
            260                 265                 270         


Gly Asp Pro Ser Ser Pro Asp Ser Leu His Tyr Leu Ser Pro Xaa Gly 
        275                 280                 285             


Val Asn Glu Tyr Leu Met Ala Leu Trp Ser Val Gly Ser Val Val Gln 
    290                 295                 300                 


Asp Tyr Asp Ser Asp Lys Leu Phe Pro Ala Phe Gly Phe Gly Ala Gln 
305                 310                 315                 320 


Val Pro Pro Asp Trp Gln Val Ser His Glu Phe Ala Leu Asn Phe Asn 
                325                 330                 335     


Pro Ser Asn Pro Tyr Cys Ala Gly Ile Gln Gly Ile Val Asp Ala Tyr 
            340                 345                 350         


Arg Gln Ala Leu Pro Gln Val Arg Leu Tyr Gly Pro Xaa Asn Phe Ala 
        355                 360                 365             


Pro Ile Ile Asn His Val Ala Arg Phe Ala Ala Gln Ala Ala His Gln 
    370                 375                 380                 


Gly Xaa 
385     


<210> 6794
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 6794
Met Ala His Cys Val Xaa Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15      


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30          


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Xaa Glu 
        35                  40                  45              


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Xaa Leu Gln Leu 
    50                  55                  60                  


Glu Tyr Arg Phe Glu Xaa Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80  


Ile Asp Asn Lys Xaa Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95      


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Xaa Leu 
            100                 105                 110         


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Xaa Ile Xaa 
        115                 120                 125             


Ser Pro Leu Pro Arg Ser Gln Leu Arg Asn 
    130                 135             


<210> 6795
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 6795
Met Ala His Cys Val Xaa Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15      


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30          


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Xaa Glu 
        35                  40                  45              


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Xaa Leu Gln Leu 
    50                  55                  60                  


Glu Tyr Arg Phe Glu Xaa Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80  


Ile Asp Asn Lys Xaa Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95      


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Xaa Leu 
            100                 105                 110         


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Xaa Ile Xaa 
        115                 120                 125             


Val Ser Ala Gln Glu Leu Lys Asp 
    130                 135     


<210> 6796
<211> 152
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<400> 6796
Met Ala His Cys Val Xaa Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15      


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30          


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Xaa Glu 
        35                  40                  45              


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Xaa Leu Gln Leu 
    50                  55                  60                  


Glu Tyr Arg Phe Glu Xaa Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80  


Ile Asp Asn Lys Xaa Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95      


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Xaa Leu 
            100                 105                 110         


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Xaa Ile Xaa 
        115                 120                 125             


Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val Val Xaa Met Glu Val 
    130                 135                 140                 


Glu Ala Arg Asn Leu Asp Lys Lys 
145                 150         


<210> 6797
<211> 174
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<400> 6797
Met Ala His Cys Val Xaa Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15      


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30          


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Xaa Glu 
        35                  40                  45              


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Xaa Leu Gln Leu 
    50                  55                  60                  


Glu Tyr Arg Phe Glu Xaa Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80  


Ile Asp Asn Lys Xaa Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95      


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Xaa Leu 
            100                 105                 110         


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Xaa Ile Xaa 
        115                 120                 125             


Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val Val Xaa Met Glu Val 
    130                 135                 140                 


Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu Gly Lys Ser Asp Pro 
145                 150                 155                 160 


Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys Trp His Leu 
                165                 170                 


<210> 6798
<211> 202
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<400> 6798
Met Ala His Cys Val Xaa Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15      


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30          


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Xaa Glu 
        35                  40                  45              


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Xaa Leu Gln Leu 
    50                  55                  60                  


Glu Tyr Arg Phe Glu Xaa Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80  


Ile Asp Asn Lys Xaa Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95      


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Xaa Leu 
            100                 105                 110         


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Xaa Ile Xaa 
        115                 120                 125             


Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val Val Xaa Met Glu Val 
    130                 135                 140                 


Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu Gly Lys Ser Asp Pro 
145                 150                 155                 160 


Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys Trp His Leu Val Tyr 
                165                 170                 175     


Arg Ser Glu Val Ile Lys Asn Asn Leu Asn Pro Xaa Trp Lys Arg Phe 
            180                 185                 190         


Ser Val Pro Val Gln His Phe Cys Gly Gly 
        195                 200         


<210> 6799
<211> 209
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<400> 6799
Met Ala His Cys Val Xaa Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15      


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30          


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Xaa Glu 
        35                  40                  45              


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Xaa Leu Gln Leu 
    50                  55                  60                  


Glu Tyr Arg Phe Glu Xaa Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80  


Ile Asp Asn Lys Xaa Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95      


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Xaa Leu 
            100                 105                 110         


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Xaa Ile Xaa 
        115                 120                 125             


Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val Val Xaa Met Glu Val 
    130                 135                 140                 


Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu Gly Lys Ser Asp Pro 
145                 150                 155                 160 


Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys Trp His Leu Val Tyr 
                165                 170                 175     


Arg Ser Glu Val Ile Lys Asn Asn Leu Asn Pro Xaa Trp Lys Arg Phe 
            180                 185                 190         


Ser Val Pro Val Gln His Phe Cys Gly Gly Asn Pro Ser Xaa Pro Ile 
        195                 200                 205             


Gln 
    


<210> 6800
<211> 231
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<400> 6800
Met Ala His Cys Val Xaa Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15      


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30          


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Xaa Glu 
        35                  40                  45              


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Xaa Leu Gln Leu 
    50                  55                  60                  


Glu Tyr Arg Phe Glu Xaa Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80  


Ile Asp Asn Lys Xaa Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95      


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Xaa Leu 
            100                 105                 110         


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Xaa Ile Xaa 
        115                 120                 125             


Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val Val Xaa Met Glu Val 
    130                 135                 140                 


Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu Gly Lys Ser Asp Pro 
145                 150                 155                 160 


Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys Trp His Leu Val Tyr 
                165                 170                 175     


Arg Ser Glu Val Ile Lys Asn Asn Leu Asn Pro Xaa Trp Lys Arg Phe 
            180                 185                 190         


Ser Val Pro Val Gln His Phe Cys Gly Gly Asn Pro Ser Xaa Pro Ile 
        195                 200                 205             


Gln Val Gln Cys Ser Asp Tyr Asp Ser Asp Gly Ser His Asp Leu Ile 
    210                 215                 220                 


Gly Xaa Phe His Xaa Ser Leu 
225                 230     


<210> 6801
<211> 304
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<400> 6801
Met Ala His Cys Val Xaa Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15      


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30          


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Xaa Glu 
        35                  40                  45              


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Xaa Leu Gln Leu 
    50                  55                  60                  


Glu Tyr Arg Phe Glu Xaa Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80  


Ile Asp Asn Lys Xaa Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95      


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Xaa Leu 
            100                 105                 110         


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Xaa Ile Xaa 
        115                 120                 125             


Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val Val Xaa Met Glu Val 
    130                 135                 140                 


Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu Gly Lys Ser Asp Pro 
145                 150                 155                 160 


Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys Trp His Leu Val Tyr 
                165                 170                 175     


Arg Ser Glu Val Ile Lys Asn Asn Leu Asn Pro Xaa Trp Lys Arg Phe 
            180                 185                 190         


Ser Val Pro Val Gln His Phe Cys Gly Gly Asn Pro Ser Xaa Pro Ile 
        195                 200                 205             


Gln Val Gln Cys Ser Asp Tyr Asp Ser Asp Gly Ser His Asp Leu Ile 
    210                 215                 220                 


Gly Xaa Phe His Xaa Ser Leu Ala Gln Leu Gln Ala Val Pro Ala Glu 
225                 230                 235                 240 


Phe Glu Cys Ile His Pro Glu Lys Gln Gln Lys Lys Lys Ser Tyr Lys 
                245                 250                 255     


Asn Ser Gly Xaa Ile Arg Val Lys Ile Cys Arg Val Glu Xaa Glu Tyr 
            260                 265                 270         


Ser Phe Leu Asp Tyr Val Met Gly Gly Cys Gln Ile Asn Phe Xaa Val 
        275                 280                 285             


Gly Val Asp Phe Xaa Gly Ser Asn Gly Asp Pro Ser Ser Pro Asp Ser 
    290                 295                 300                 


<210> 6802
<211> 427
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<400> 6802
Met Ala His Cys Val Xaa Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15      


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30          


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Xaa Glu 
        35                  40                  45              


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Xaa Leu Gln Leu 
    50                  55                  60                  


Glu Tyr Arg Phe Glu Xaa Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80  


Ile Asp Asn Lys Xaa Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95      


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Xaa Leu 
            100                 105                 110         


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Xaa Ile Xaa 
        115                 120                 125             


Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val Val Xaa Met Glu Val 
    130                 135                 140                 


Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu Gly Lys Ser Asp Pro 
145                 150                 155                 160 


Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys Trp His Leu Val Tyr 
                165                 170                 175     


Arg Ser Glu Val Ile Lys Asn Asn Leu Asn Pro Xaa Trp Lys Arg Phe 
            180                 185                 190         


Ser Val Pro Val Gln His Phe Cys Gly Gly Asn Pro Ser Xaa Pro Ile 
        195                 200                 205             


Gln Val Gln Cys Ser Asp Tyr Asp Ser Asp Gly Ser His Asp Leu Ile 
    210                 215                 220                 


Gly Xaa Phe His Xaa Ser Leu Ala Gln Leu Gln Ala Val Pro Ala Glu 
225                 230                 235                 240 


Phe Glu Cys Ile His Pro Glu Lys Gln Gln Lys Lys Lys Ser Tyr Lys 
                245                 250                 255     


Asn Ser Gly Xaa Ile Arg Val Lys Ile Cys Arg Val Glu Xaa Glu Tyr 
            260                 265                 270         


Ser Phe Leu Asp Tyr Val Met Gly Gly Cys Gln Ile Asn Phe Xaa Val 
        275                 280                 285             


Gly Val Asp Phe Xaa Gly Ser Asn Gly Asp Pro Ser Ser Pro Asp Ser 
    290                 295                 300                 


Leu His Tyr Leu Ser Pro Xaa Gly Val Asn Glu Tyr Leu Met Ala Leu 
305                 310                 315                 320 


Trp Ser Val Gly Ser Val Val Gln Asp Tyr Asp Ser Asp Lys Leu Phe 
                325                 330                 335     


Pro Ala Phe Gly Phe Gly Ala Gln Val Pro Pro Asp Trp Gln Val Ser 
            340                 345                 350         


His Glu Phe Ala Leu Asn Phe Asn Pro Ser Asn Pro Tyr Cys Ala Gly 
        355                 360                 365             


Ile Gln Gly Ile Val Asp Ala Tyr Arg Gln Ala Leu Pro Gln Val Arg 
    370                 375                 380                 


Leu Tyr Gly Pro Xaa Asn Phe Ala Pro Ile Ile Asn His Val Ala Arg 
385                 390                 395                 400 


Phe Ala Ala Gln Ala Ala His Gln Gly Xaa Ala Ser Asp Met Asn Gly 
                405                 410                 415     


Leu Val Pro Ser Asn Xaa Ser Cys Cys Cys Cys 
            420                 425         


<210> 6803
<211> 481
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<400> 6803
Met Ala His Cys Val Xaa Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15      


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30          


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Xaa Glu 
        35                  40                  45              


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Xaa Leu Gln Leu 
    50                  55                  60                  


Glu Tyr Arg Phe Glu Xaa Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80  


Ile Asp Asn Lys Xaa Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95      


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Xaa Leu 
            100                 105                 110         


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Xaa Ile Xaa 
        115                 120                 125             


Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val Val Xaa Met Glu Val 
    130                 135                 140                 


Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu Gly Lys Ser Asp Pro 
145                 150                 155                 160 


Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys Trp His Leu Val Tyr 
                165                 170                 175     


Arg Ser Glu Val Ile Lys Asn Asn Leu Asn Pro Xaa Trp Lys Arg Phe 
            180                 185                 190         


Ser Val Pro Val Gln His Phe Cys Gly Gly Asn Pro Ser Xaa Pro Ile 
        195                 200                 205             


Gln Val Gln Cys Ser Asp Tyr Asp Ser Asp Gly Ser His Asp Leu Ile 
    210                 215                 220                 


Gly Xaa Phe His Xaa Ser Leu Ala Gln Leu Gln Ala Val Pro Ala Glu 
225                 230                 235                 240 


Phe Glu Cys Ile His Pro Glu Lys Gln Gln Lys Lys Lys Ser Tyr Lys 
                245                 250                 255     


Asn Ser Gly Xaa Ile Arg Val Lys Ile Cys Arg Val Glu Xaa Glu Tyr 
            260                 265                 270         


Ser Phe Leu Asp Tyr Val Met Gly Gly Cys Gln Ile Asn Phe Xaa Val 
        275                 280                 285             


Gly Val Asp Phe Xaa Gly Ser Asn Gly Asp Pro Ser Ser Pro Asp Ser 
    290                 295                 300                 


Leu His Tyr Leu Ser Pro Xaa Gly Val Asn Glu Tyr Leu Met Ala Leu 
305                 310                 315                 320 


Trp Ser Val Gly Ser Val Val Gln Asp Tyr Asp Ser Asp Lys Leu Phe 
                325                 330                 335     


Pro Ala Phe Gly Phe Gly Ala Gln Val Pro Pro Asp Trp Gln Val Ser 
            340                 345                 350         


His Glu Phe Ala Leu Asn Phe Asn Pro Ser Asn Pro Tyr Cys Ala Gly 
        355                 360                 365             


Ile Gln Gly Ile Val Asp Ala Tyr Arg Gln Ala Leu Pro Gln Val Arg 
    370                 375                 380                 


Leu Tyr Gly Pro Xaa Asn Phe Ala Pro Ile Ile Asn His Val Ala Arg 
385                 390                 395                 400 


Phe Ala Ala Gln Ala Ala His Gln Gly Xaa Ala Ser Gln Tyr Phe Met 
                405                 410                 415     


Leu Leu Leu Leu Xaa Asp Gly Ala Val Xaa Asp Val Glu Ala Xaa Arg 
            420                 425                 430         


Glu Ala Val Ala Pro Arg Glu Ala Leu Ala Gln Xaa Val Leu Ala Glu 
        435                 440                 445             


Val Pro Xaa Gln Leu Val Ser Tyr Phe Arg Ala Gln Gly Trp Ala Pro 
    450                 455                 460                 


Leu Lys Pro Leu Pro Pro Ser Ala Lys Asp Pro Ala Gln Ala Pro Gln 
465                 470                 475                 480 


Ala 
    


<210> 6804
<211> 533
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<400> 6804
Met Ala His Cys Val Xaa Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15      


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30          


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Xaa Glu 
        35                  40                  45              


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Xaa Leu Gln Leu 
    50                  55                  60                  


Glu Tyr Arg Phe Glu Xaa Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80  


Ile Asp Asn Lys Xaa Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95      


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Xaa Leu 
            100                 105                 110         


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Xaa Ile Xaa 
        115                 120                 125             


Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val Val Xaa Met Glu Val 
    130                 135                 140                 


Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu Gly Lys Ser Asp Pro 
145                 150                 155                 160 


Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys Trp His Leu Val Tyr 
                165                 170                 175     


Arg Ser Glu Val Ile Lys Asn Asn Leu Asn Pro Xaa Trp Lys Arg Phe 
            180                 185                 190         


Ser Val Pro Val Gln His Phe Cys Gly Gly Asn Pro Ser Xaa Pro Ile 
        195                 200                 205             


Gln Val Gln Cys Ser Asp Tyr Asp Ser Asp Gly Ser His Asp Leu Ile 
    210                 215                 220                 


Gly Xaa Phe His Xaa Ser Leu Ala Gln Leu Gln Ala Val Pro Ala Glu 
225                 230                 235                 240 


Phe Glu Cys Ile His Pro Glu Lys Gln Gln Lys Lys Lys Ser Tyr Lys 
                245                 250                 255     


Asn Ser Gly Xaa Ile Arg Val Lys Ile Cys Arg Val Glu Xaa Glu Tyr 
            260                 265                 270         


Ser Phe Leu Asp Tyr Val Met Gly Gly Cys Gln Ile Asn Phe Xaa Val 
        275                 280                 285             


Gly Val Asp Phe Xaa Gly Ser Asn Gly Asp Pro Ser Ser Pro Asp Ser 
    290                 295                 300                 


Leu His Tyr Leu Ser Pro Xaa Gly Val Asn Glu Tyr Leu Met Ala Leu 
305                 310                 315                 320 


Trp Ser Val Gly Ser Val Val Gln Asp Tyr Asp Ser Asp Lys Leu Phe 
                325                 330                 335     


Pro Ala Phe Gly Phe Gly Ala Gln Val Pro Pro Asp Trp Gln Val Ser 
            340                 345                 350         


His Glu Phe Ala Leu Asn Phe Asn Pro Ser Asn Pro Tyr Cys Ala Gly 
        355                 360                 365             


Ile Gln Gly Ile Val Asp Ala Tyr Arg Gln Ala Leu Pro Gln Val Arg 
    370                 375                 380                 


Leu Tyr Gly Pro Xaa Asn Phe Ala Pro Ile Ile Asn His Val Ala Arg 
385                 390                 395                 400 


Phe Ala Ala Gln Ala Ala His Gln Gly Xaa Ala Ser Tyr Phe Met Leu 
                405                 410                 415     


Leu Leu Leu Xaa Asp Gly Ala Val Xaa Asp Val Glu Ala Xaa Arg Glu 
            420                 425                 430         


Ala Val Val Arg Ala Ser Asn Leu Pro Met Ser Val Ile Ile Val Gly 
        435                 440                 445             


Val Gly Gly Ala Asp Phe Glu Ala Met Glu Gln Leu Asp Ala Asp Gly 
    450                 455                 460                 


Gly Pro Leu His Xaa Arg Ser Gly Gln Ala Ala Ala Arg Asp Ile Val 
465                 470                 475                 480 


Gln Phe Val Pro Tyr Arg Arg Phe Gln Asn Ala Pro Arg Glu Ala Leu 
                485                 490                 495     


Ala Gln Xaa Val Leu Ala Glu Val Pro Xaa Gln Leu Val Ser Tyr Phe 
            500                 505                 510         


Arg Ala Gln Gly Trp Ala Pro Leu Lys Pro Leu Pro Pro Ser Ala Lys 
        515                 520                 525             


Asp Pro Ala Gln Ala 
    530             


<210> 6805
<211> 537
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<400> 6805
Met Ala His Cys Val Xaa Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15      


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30          


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Xaa Glu 
        35                  40                  45              


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Xaa Leu Gln Leu 
    50                  55                  60                  


Glu Tyr Arg Phe Glu Xaa Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80  


Ile Asp Asn Lys Xaa Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95      


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Xaa Leu 
            100                 105                 110         


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Xaa Ile Xaa 
        115                 120                 125             


Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val Val Xaa Met Glu Val 
    130                 135                 140                 


Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu Gly Lys Ser Asp Pro 
145                 150                 155                 160 


Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys Trp His Leu Val Tyr 
                165                 170                 175     


Arg Ser Glu Val Ile Lys Asn Asn Leu Asn Pro Xaa Trp Lys Arg Phe 
            180                 185                 190         


Ser Val Pro Val Gln His Phe Cys Gly Gly Asn Pro Ser Xaa Pro Ile 
        195                 200                 205             


Gln Val Gln Cys Ser Asp Tyr Asp Ser Asp Gly Ser His Asp Leu Ile 
    210                 215                 220                 


Gly Xaa Phe His Xaa Ser Leu Ala Gln Leu Gln Ala Val Pro Ala Glu 
225                 230                 235                 240 


Phe Glu Cys Ile His Pro Glu Lys Gln Gln Lys Lys Lys Ser Tyr Lys 
                245                 250                 255     


Asn Ser Gly Xaa Ile Arg Val Lys Ile Cys Arg Val Glu Xaa Glu Tyr 
            260                 265                 270         


Ser Phe Leu Asp Tyr Val Met Gly Gly Cys Gln Ile Asn Phe Xaa Val 
        275                 280                 285             


Gly Val Asp Phe Xaa Gly Ser Asn Gly Asp Pro Ser Ser Pro Asp Ser 
    290                 295                 300                 


Leu His Tyr Leu Ser Pro Xaa Gly Val Asn Glu Tyr Leu Met Ala Leu 
305                 310                 315                 320 


Trp Ser Val Gly Ser Val Val Gln Asp Tyr Asp Ser Asp Lys Leu Phe 
                325                 330                 335     


Pro Ala Phe Gly Phe Gly Ala Gln Val Pro Pro Asp Trp Gln Val Ser 
            340                 345                 350         


His Glu Phe Ala Leu Asn Phe Asn Pro Ser Asn Pro Tyr Cys Ala Gly 
        355                 360                 365             


Ile Gln Gly Ile Val Asp Ala Tyr Arg Gln Ala Leu Pro Gln Val Arg 
    370                 375                 380                 


Leu Tyr Gly Pro Xaa Asn Phe Ala Pro Ile Ile Asn His Val Ala Arg 
385                 390                 395                 400 


Phe Ala Ala Gln Ala Ala His Gln Gly Xaa Ala Ser Gln Tyr Phe Met 
                405                 410                 415     


Leu Leu Leu Leu Xaa Asp Gly Ala Val Xaa Asp Val Glu Ala Xaa Arg 
            420                 425                 430         


Glu Ala Val Val Arg Ala Ser Asn Leu Pro Met Ser Val Ile Ile Val 
        435                 440                 445             


Gly Val Gly Gly Ala Asp Phe Glu Ala Met Glu Gln Leu Asp Ala Asp 
    450                 455                 460                 


Gly Gly Pro Leu His Xaa Arg Ser Gly Gln Ala Ala Ala Arg Asp Ile 
465                 470                 475                 480 


Val Gln Phe Val Pro Tyr Arg Arg Phe Gln Asn Ala Pro Arg Glu Ala 
                485                 490                 495     


Leu Ala Gln Xaa Val Leu Ala Glu Val Pro Xaa Gln Leu Val Ser Tyr 
            500                 505                 510         


Phe Arg Ala Gln Gly Trp Ala Pro Leu Lys Pro Leu Pro Pro Ser Ala 
        515                 520                 525             


Lys Asp Pro Ala Gln Ala Pro Gln Ala 
    530                 535         


<210> 6806
<211> 542
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<400> 6806
Met Lys Met Met His Met Ala His Cys Val Xaa Leu Val Gln Leu Ser 
1               5                   10                  15      


Ile Ser Cys Asp His Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp 
            20                  25                  30          


Pro Leu Cys Val Leu Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu 
        35                  40                  45              


Leu Gly Arg Xaa Glu Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser 
    50                  55                  60                  


Lys Xaa Leu Gln Leu Glu Tyr Arg Phe Glu Xaa Val Gln Lys Leu Arg 
65                  70                  75                  80  


Phe Gly Ile Tyr Asp Ile Asp Asn Lys Xaa Pro Glu Leu Arg Asp Asp 
                85                  90                  95      


Asp Phe Leu Gly Gly Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser 
            100                 105                 110         


Gln Val Leu Xaa Leu Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly 
        115                 120                 125             


Arg Gly Xaa Ile Xaa Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val 
    130                 135                 140                 


Val Xaa Met Glu Val Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu 
145                 150                 155                 160 


Gly Lys Ser Asp Pro Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys 
                165                 170                 175     


Trp His Leu Val Tyr Arg Ser Glu Val Ile Lys Asn Asn Leu Asn Pro 
            180                 185                 190         


Xaa Trp Lys Arg Phe Ser Val Pro Val Gln His Phe Cys Gly Gly Asn 
        195                 200                 205             


Pro Ser Xaa Pro Ile Gln Val Gln Cys Ser Asp Tyr Asp Ser Asp Gly 
    210                 215                 220                 


Ser His Asp Leu Ile Gly Xaa Phe His Xaa Ser Leu Ala Gln Leu Gln 
225                 230                 235                 240 


Ala Val Pro Ala Glu Phe Glu Cys Ile His Pro Glu Lys Gln Gln Lys 
                245                 250                 255     


Lys Lys Ser Tyr Lys Asn Ser Gly Xaa Ile Arg Val Lys Ile Cys Arg 
            260                 265                 270         


Val Glu Xaa Glu Tyr Ser Phe Leu Asp Tyr Val Met Gly Gly Cys Gln 
        275                 280                 285             


Ile Asn Phe Xaa Val Gly Val Asp Phe Xaa Gly Ser Asn Gly Asp Pro 
    290                 295                 300                 


Ser Ser Pro Asp Ser Leu His Tyr Leu Ser Pro Xaa Gly Val Asn Glu 
305                 310                 315                 320 


Tyr Leu Met Ala Leu Trp Ser Val Gly Ser Val Val Gln Asp Tyr Asp 
                325                 330                 335     


Ser Asp Lys Leu Phe Pro Ala Phe Gly Phe Gly Ala Gln Val Pro Pro 
            340                 345                 350         


Asp Trp Gln Val Ser His Glu Phe Ala Leu Asn Phe Asn Pro Ser Asn 
        355                 360                 365             


Pro Tyr Cys Ala Gly Ile Gln Gly Ile Val Asp Ala Tyr Arg Gln Ala 
    370                 375                 380                 


Leu Pro Gln Val Arg Leu Tyr Gly Pro Xaa Asn Phe Ala Pro Ile Ile 
385                 390                 395                 400 


Asn His Val Ala Arg Phe Ala Ala Gln Ala Ala His Gln Gly Xaa Ala 
                405                 410                 415     


Ser Gln Tyr Phe Met Leu Leu Leu Leu Xaa Asp Gly Ala Val Xaa Asp 
            420                 425                 430         


Val Glu Ala Xaa Arg Glu Ala Val Val Arg Ala Ser Asn Leu Pro Met 
        435                 440                 445             


Ser Val Ile Ile Val Gly Val Gly Gly Ala Asp Phe Glu Ala Met Glu 
    450                 455                 460                 


Gln Leu Asp Ala Asp Gly Gly Pro Leu His Xaa Arg Ser Gly Gln Ala 
465                 470                 475                 480 


Ala Ala Arg Asp Ile Val Gln Phe Val Pro Tyr Arg Arg Phe Gln Asn 
                485                 490                 495     


Ala Pro Arg Glu Ala Leu Ala Gln Xaa Val Leu Ala Glu Val Pro Xaa 
            500                 505                 510         


Gln Leu Val Ser Tyr Phe Arg Ala Gln Gly Trp Ala Pro Leu Lys Pro 
        515                 520                 525             


Leu Pro Pro Ser Ala Lys Asp Pro Ala Gln Ala Pro Gln Ala 
    530                 535                 540         


<210> 6807
<211> 208
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<400> 6807
Xaa Asn Pro Tyr Cys Ala Gly Ile Gln Gly Ile Val Asp Ala Tyr Arg 
1               5                   10                  15      


Gln Ala Leu Pro Gln Val Arg Leu Tyr Gly Pro Xaa Asn Phe Ala Pro 
            20                  25                  30          


Ile Ile Asn His Val Ala Arg Phe Ala Ala Gln Ala Ala His Gln Gly 
        35                  40                  45              


Xaa Ala Ser Gln Tyr Phe Met Leu Leu Leu Leu Xaa Asp Gly Ala Val 
    50                  55                  60                  


Xaa Asp Val Glu Ala Xaa Arg Glu Ala Val Val Arg Ala Ser Asn Leu 
65                  70                  75                  80  


Pro Met Ser Val Ile Ile Val Gly Val Gly Gly Ala Asp Phe Glu Ala 
                85                  90                  95      


Met Glu Gln Leu Asp Ala Asp Gly Gly Pro Leu His Xaa Arg Ser Gly 
            100                 105                 110         


Gln Ala Ala Ala Arg Asp Ile Val Gln Phe Val Pro Tyr Arg Arg Phe 
        115                 120                 125             


Gln Asn Val Ser Pro Ser Gly Gly Ile Gly Xaa Asp Arg Ala Arg Arg 
    130                 135                 140                 


Ser Ala His Xaa Xaa Gly Leu Ile Leu Gln Gly Pro Gly Leu Gly Pro 
145                 150                 155                 160 


Ala Gln Ala Xaa Ser Xaa Leu Ser Gln Gly Ser Cys Xaa Gly Pro Pro 
                165                 170                 175     


Gly Leu Gly Ser Leu Gly Gly Cys Gly Lys Ser Ser Ile Leu Cys Pro 
            180                 185                 190         


Arg Gly Pro Ser Gly Pro Gln Pro Asn Pro Ser His Ser Pro Gln Cys 
        195                 200                 205             


<210> 6808
<211> 9
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<400> 6808
Met Ala Ala Gln Cys Val Xaa Lys Val 
1               5                   


<210> 6809
<211> 79
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<400> 6809
Met Ala Ala Gln Cys Val Xaa Lys Val Ala Leu Asn Val Ser Cys Ala 
1               5                   10                  15      


Asn Leu Leu Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val 
            20                  25                  30          


Leu Phe Leu Asn Xaa Ser Gly Gln Gln Trp Tyr Glu Val Glu Arg Xaa 
        35                  40                  45              


Glu Arg Ile Lys Asn Cys Leu Asn Pro Gln Phe Ser Lys Xaa Phe Ile 
    50                  55                  60                  


Ile Asp Tyr Tyr Phe Glu Val Val Gln Lys Leu Lys Phe Gly Val 
65                  70                  75                  


<210> 6810
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 6810
Met Ala Ala Gln Cys Val Xaa Lys Val Ala Leu Asn Val Ser Cys Ala 
1               5                   10                  15      


Asn Leu Leu Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val 
            20                  25                  30          


Leu Phe Leu Asn Xaa Ser Gly Gln Gln Trp Tyr Glu Val Glu Arg Xaa 
        35                  40                  45              


Glu Arg Ile Lys Asn Cys Leu Asn Pro Gln Phe Ser Lys Xaa Phe Ile 
    50                  55                  60                  


Ile Asp Tyr Tyr Phe Glu Val Val Gln Lys Leu Lys Phe Gly Val Tyr 
65                  70                  75                  80  


Asp Ile Asp Asn Lys Xaa Ile Glu Leu Ser Asp Asp Asp Phe Leu Gly 
                85                  90                  95      


Glu Cys Glu Cys Xaa Leu Gly Gln Ile Val Ser Ser Lys Lys Leu Xaa 
            100                 105                 110         


Arg Pro Leu Val Met Lys Xaa Gly Arg Pro Ala Gly Lys Gly Ser Ile 
        115                 120                 125             


Xaa Ile Ser Ala Glu Glu Ile 
    130                 135 


<210> 6811
<211> 139
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 6811
Met Ala Ala Gln Cys Val Xaa Lys Val Ala Leu Asn Val Ser Cys Ala 
1               5                   10                  15      


Asn Leu Leu Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val 
            20                  25                  30          


Leu Phe Leu Asn Xaa Ser Gly Gln Gln Trp Tyr Glu Val Glu Arg Xaa 
        35                  40                  45              


Glu Arg Ile Lys Asn Cys Leu Asn Pro Gln Phe Ser Lys Xaa Phe Ile 
    50                  55                  60                  


Ile Asp Tyr Tyr Phe Glu Val Val Gln Lys Leu Lys Phe Gly Val Tyr 
65                  70                  75                  80  


Asp Ile Asp Asn Lys Xaa Ile Glu Leu Ser Asp Asp Asp Phe Leu Gly 
                85                  90                  95      


Glu Cys Glu Cys Xaa Leu Gly Gln Ile Val Ser Ser Lys Lys Leu Xaa 
            100                 105                 110         


Arg Pro Leu Val Met Lys Xaa Gly Arg Pro Ala Gly Lys Gly Ser Ile 
        115                 120                 125             


Xaa Ile Ser Ala Glu Glu Ile Lys Asp Asn Arg 
    130                 135                 


<210> 6812
<211> 153
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 6812
Met Ala Ala Gln Cys Val Xaa Lys Val Ala Leu Asn Val Ser Cys Ala 
1               5                   10                  15      


Asn Leu Leu Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val 
            20                  25                  30          


Leu Phe Leu Asn Xaa Ser Gly Gln Gln Trp Tyr Glu Val Glu Arg Xaa 
        35                  40                  45              


Glu Arg Ile Lys Asn Cys Leu Asn Pro Gln Phe Ser Lys Xaa Phe Ile 
    50                  55                  60                  


Ile Asp Tyr Tyr Phe Glu Val Val Gln Lys Leu Lys Phe Gly Val Tyr 
65                  70                  75                  80  


Asp Ile Asp Asn Lys Xaa Ile Glu Leu Ser Asp Asp Asp Phe Leu Gly 
                85                  90                  95      


Glu Cys Glu Cys Xaa Leu Gly Gln Ile Val Ser Ser Lys Lys Leu Xaa 
            100                 105                 110         


Arg Pro Leu Val Met Lys Xaa Gly Arg Pro Ala Gly Lys Gly Ser Ile 
        115                 120                 125             


Xaa Ile Ser Ala Glu Glu Ile Lys Asp Asn Arg Val Val Leu Phe Glu 
    130                 135                 140                 


Met Glu Ala Arg Lys Leu Asp Asn Lys 
145                 150             


<210> 6813
<211> 234
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<400> 6813
Met Ala Ala Gln Cys Val Xaa Lys Val Ala Leu Asn Val Ser Cys Ala 
1               5                   10                  15      


Asn Leu Leu Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val 
            20                  25                  30          


Leu Phe Leu Asn Xaa Ser Gly Gln Gln Trp Tyr Glu Val Glu Arg Xaa 
        35                  40                  45              


Glu Arg Ile Lys Asn Cys Leu Asn Pro Gln Phe Ser Lys Xaa Phe Ile 
    50                  55                  60                  


Ile Asp Tyr Tyr Phe Glu Val Val Gln Lys Leu Lys Phe Gly Val Tyr 
65                  70                  75                  80  


Asp Ile Asp Asn Lys Xaa Ile Glu Leu Ser Asp Asp Asp Phe Leu Gly 
                85                  90                  95      


Glu Cys Glu Cys Xaa Leu Gly Gln Ile Val Ser Ser Lys Lys Leu Xaa 
            100                 105                 110         


Arg Pro Leu Val Met Lys Xaa Gly Arg Pro Ala Gly Lys Gly Ser Ile 
        115                 120                 125             


Xaa Ile Ser Ala Glu Glu Ile Lys Asp Asn Arg Val Val Leu Phe Glu 
    130                 135                 140                 


Met Glu Ala Arg Lys Leu Asp Asn Lys Asp Leu Phe Gly Lys Ser Asp 
145                 150                 155                 160 


Pro Tyr Leu Glu Phe His Lys Gln Xaa Ser Asp Gly Asn Trp Leu Met 
                165                 170                 175     


Val His Arg Xaa Glu Val Val Lys Asn Asn Leu Asn Pro Val Trp Arg 
            180                 185                 190         


Pro Phe Lys Ile Ser Leu Asn Ser Leu Cys Tyr Gly Asp Met Asp Lys 
        195                 200                 205             


Xaa Ile Lys Val Glu Cys Tyr Asp Tyr Asp Asn Asp Gly Ser His Asp 
    210                 215                 220                 


Leu Ile Gly Xaa Phe Gln Xaa Xaa Met Xaa 
225                 230                 


<210> 6814
<211> 537
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<400> 6814
Met Ala Ala Gln Cys Val Xaa Lys Val Ala Leu Asn Val Ser Cys Ala 
1               5                   10                  15      


Asn Leu Leu Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val 
            20                  25                  30          


Leu Phe Leu Asn Xaa Ser Gly Gln Gln Trp Tyr Glu Val Glu Arg Xaa 
        35                  40                  45              


Glu Arg Ile Lys Asn Cys Leu Asn Pro Gln Phe Ser Lys Xaa Phe Ile 
    50                  55                  60                  


Ile Asp Tyr Tyr Phe Glu Val Val Gln Lys Leu Lys Phe Gly Val Tyr 
65                  70                  75                  80  


Asp Ile Asp Asn Lys Xaa Ile Glu Leu Ser Asp Asp Asp Phe Leu Gly 
                85                  90                  95      


Glu Cys Glu Cys Xaa Leu Gly Gln Ile Val Ser Ser Lys Lys Leu Xaa 
            100                 105                 110         


Arg Pro Leu Val Met Lys Xaa Gly Arg Pro Ala Gly Lys Gly Ser Ile 
        115                 120                 125             


Xaa Ile Ser Ala Glu Glu Ile Lys Asp Asn Arg Val Val Leu Phe Glu 
    130                 135                 140                 


Met Glu Ala Arg Lys Leu Asp Asn Lys Asp Leu Phe Gly Lys Ser Asp 
145                 150                 155                 160 


Pro Tyr Leu Glu Phe His Lys Gln Xaa Ser Asp Gly Asn Trp Leu Met 
                165                 170                 175     


Val His Arg Xaa Glu Val Val Lys Asn Asn Leu Asn Pro Val Trp Arg 
            180                 185                 190         


Pro Phe Lys Ile Ser Leu Asn Ser Leu Cys Tyr Gly Asp Met Asp Lys 
        195                 200                 205             


Xaa Ile Lys Val Glu Cys Tyr Asp Tyr Asp Asn Asp Gly Ser His Asp 
    210                 215                 220                 


Leu Ile Gly Xaa Phe Gln Xaa Xaa Met Xaa Lys Leu Lys Glu Ala Ser 
225                 230                 235                 240 


Arg Ser Ser Pro Val Glu Phe Glu Cys Ile Asn Glu Lys Lys Arg Gln 
                245                 250                 255     


Lys Lys Lys Ser Tyr Lys Asn Ser Gly Val Ile Ser Val Lys Gln Cys 
            260                 265                 270         


Glu Ile Xaa Val Glu Cys Xaa Phe Leu Asp Tyr Ile Met Gly Gly Cys 
        275                 280                 285             


Gln Leu Asn Phe Xaa Val Gly Val Asp Phe Xaa Gly Ser Asn Gly Asp 
    290                 295                 300                 


Pro Arg Ser Pro Asp Ser Leu His Tyr Ile Ser Pro Asn Gly Val Asn 
305                 310                 315                 320 


Glu Tyr Leu Xaa Ala Leu Trp Ser Val Gly Leu Val Ile Gln Asp Tyr 
                325                 330                 335     


Asp Ala Asp Lys Met Phe Pro Ala Phe Gly Phe Gly Ala Gln Ile Pro 
            340                 345                 350         


Pro Gln Trp Gln Val Ser His Glu Phe Pro Met Asn Phe Asn Pro Ser 
        355                 360                 365             


Asn Pro Tyr Cys Asn Gly Ile Gln Gly Ile Val Glu Ala Tyr Arg Ser 
    370                 375                 380                 


Cys Leu Pro Gln Ile Lys Leu Tyr Gly Pro Xaa Asn Phe Ser Pro Ile 
385                 390                 395                 400 


Ile Asn His Val Ala Arg Phe Ala Ala Ala Ala Xaa Gln Gln Gln Xaa 
                405                 410                 415     


Ala Ser Gln Tyr Phe Val Leu Leu Ile Ile Xaa Asp Gly Val Ile Xaa 
            420                 425                 430         


Asp Leu Asp Glu Xaa Arg Gln Ala Ile Val Asn Ala Ser Arg Leu Pro 
        435                 440                 445             


Met Ser Ile Ile Ile Val Gly Val Gly Gly Ala Asp Phe Ser Ala Met 
    450                 455                 460                 


Glu Phe Leu Asp Gly Asp Gly Gly Ser Leu Arg Ser Pro Leu Gly Glu 
465                 470                 475                 480 


Val Ala Ile Arg Asp Ile Val Gln Phe Val Pro Phe Arg Gln Phe Gln 
                485                 490                 495     


Asn Ala Pro Lys Glu Ala Leu Ala Gln Cys Val Leu Ala Glu Ile Pro 
            500                 505                 510         


Gln Gln Val Val Gly Tyr Phe Asn Xaa Tyr Lys Leu Leu Pro Pro Lys 
        515                 520                 525             


Asn Pro Ala Xaa Lys Gln Gln Lys Gln 
    530                 535         


<210> 6815
<211> 262
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<400> 6815
Xaa Lys Xaa Ile Glu Leu Ser Asp Asp Asp Phe Leu Gly Glu Cys Glu 
1               5                   10                  15      


Cys Xaa Leu Gly Gln Ile Val Ser Ser Lys Lys Leu Xaa Arg Pro Leu 
            20                  25                  30          


Val Met Lys Xaa Gly Arg Pro Ala Gly Lys Gly Ser Ile Xaa Ile Ser 
        35                  40                  45              


Ala Glu Glu Ile Lys Asp Asn Arg Val Val Leu Phe Glu Met Glu Ala 
    50                  55                  60                  


Arg Lys Leu Asp Asn Lys Val Val Lys Asn Asn Leu Asn Pro Val Trp 
65                  70                  75                  80  


Arg Pro Phe Lys Ile Ser Leu Asn Ser Leu Cys Tyr Gly Asp Met Asp 
                85                  90                  95      


Lys Xaa Ile Lys Val Glu Cys Tyr Asp Tyr Asp Asn Asp Gly Ser His 
            100                 105                 110         


Asp Leu Ile Gly Xaa Phe Gln Xaa Xaa Met Xaa Lys Leu Lys Glu Ala 
        115                 120                 125             


Ser Arg Ser Ser Pro Val Glu Phe Glu Cys Ile Asn Glu Lys Lys Arg 
    130                 135                 140                 


Gln Lys Lys Lys Ser Tyr Lys Asn Ser Gly Val Ile Ser Val Lys Gln 
145                 150                 155                 160 


Cys Glu Ile Xaa Val Glu Cys Xaa Phe Leu Asp Tyr Ile Met Gly Gly 
                165                 170                 175     


Cys Gln Leu Asn Phe Xaa Val Gly Val Asp Phe Xaa Gly Ser Asn Gly 
            180                 185                 190         


Asp Pro Arg Ser Pro Asp Ser Leu His Tyr Ile Ser Pro Asn Gly Val 
        195                 200                 205             


Asn Glu Tyr Leu Xaa Ala Leu Trp Ser Val Gly Leu Val Ile Gln Asp 
    210                 215                 220                 


Tyr Asp Ala Asp Lys Met Phe Pro Ala Phe Gly Phe Gly Ala Gln Ile 
225                 230                 235                 240 


Pro Pro Gln Trp Gln Val Ser His Glu Phe Pro Met Asn Phe Asn Pro 
                245                 250                 255     


Ser Asn Pro Tyr Cys Asn 
            260         


<210> 6816
<211> 515
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<400> 6816
Met Ala Trp Pro Tyr Phe Leu Asp Cys His Arg Tyr Phe Xaa Arg Glu 
1               5                   10                  15      


Asp Glu Gly Cys Tyr Asp Pro Leu Glu Lys Leu Arg Gly Gly Leu Glu 
            20                  25                  30          


Ala Asp Glu Ala Leu Pro Ser Gly Leu Pro Pro Xaa Phe Ile Arg Phe 
        35                  40                  45              


Ser His His Ser Tyr Ala Gln Met Val Arg Val Leu Arg Arg Xaa Ala 
    50                  55                  60                  


Ser Arg Cys Ala His Val Ala Arg Xaa Tyr Ser Ile Gly Arg Ser Phe 
65                  70                  75                  80  


Asp Gly Arg Glu Leu Leu Val Ile Glu Phe Ser Ser Arg Pro Gly Gln 
                85                  90                  95      


His Glu Leu Met Glu Pro Glu Val Lys Leu Ile Gly Asn Ile His Gly 
            100                 105                 110         


Asn Glu Val Ala Gly Arg Glu Met Leu Ile Tyr Leu Ala Gln Tyr Leu 
        115                 120                 125             


Cys Ser Glu Tyr Leu Leu Gly Asn Pro Arg Ile Gln Arg Leu Leu Asn 
    130                 135                 140                 


Xaa Xaa Arg Ile His Leu Leu Pro Ser Met Asn Pro Asp Gly Tyr Glu 
145                 150                 155                 160 


Val Ala Ala Ala Glu Gly Ala Gly Tyr Asn Gly Trp Xaa Ser Gly Arg 
                165                 170                 175     


Gln Asn Ala Gln Asn Leu Asp Leu Asn Arg Asn Phe Pro Asp Leu Xaa 
            180                 185                 190         


Ser Glu Tyr Tyr Arg Leu Ala Glu Xaa Arg Gly Ala Arg Ser Asp His 
        195                 200                 205             


Ile Pro Ile Pro Gln His Tyr Trp Trp Gly Lys Val Ala Pro Glu Xaa 
    210                 215                 220                 


Lys Ala Ile Met Lys Trp Met Gln Xaa Ile Pro Phe Val Leu Ser Ala 
225                 230                 235                 240 


Ser Leu His Gly Gly Asp Leu Val Val Ser Tyr Pro Phe Asp Phe Ser 
                245                 250                 255     


Lys His Pro Gln Glu Glu Lys Met Phe Ser Pro Xaa Pro Asp Glu Lys 
            260                 265                 270         


Met Phe Lys Leu Leu Ser Arg Ala Tyr Ala Asp Val His Pro Met Met 
        275                 280                 285             


Met Asp Arg Ser Glu Asn Arg Cys Gly Gly Asn Phe Leu Lys Arg Gly 
    290                 295                 300                 


Ser Ile Ile Asn Gly Ala Asp Trp Tyr Ser Phe Xaa Gly Gly Met Ser 
305                 310                 315                 320 


Asp Phe Asn Tyr Leu His Xaa Asn Cys Phe Glu Ile Xaa Val Glu Leu 
                325                 330                 335     


Gly Cys Val Lys Phe Pro Pro Glu Glu Ala Leu Tyr Ile Leu Trp Gln 
            340                 345                 350         


His Asn Lys Glu Ser Leu Leu Asn Phe Val Glu Xaa Val His Arg Gly 
        355                 360                 365             


Ile Lys Gly Val Val Xaa Asp Lys Phe Gly Lys Pro Val Lys Asn Ala 
    370                 375                 380                 


Arg Ile Ser Val Lys Gly Ile Arg His Asp Ile Xaa Xaa Ala Pro Asp 
385                 390                 395                 400 


Gly Asp Tyr Trp Arg Leu Leu Pro Pro Gly Ile His Ile Val Ile Ala 
                405                 410                 415     


Gln Ala Pro Gly Tyr Ala Lys Val Ile Lys Lys Val Ile Ile Pro Ala 
            420                 425                 430         


Arg Met Lys Arg Ala Gly Arg Val Asp Phe Ile Leu Gln Pro Leu Gly 
        435                 440                 445             


Met Gly Pro Lys Asn Phe Ile His Gly Leu Arg Arg Xaa Gly Pro His 
    450                 455                 460                 


Asp Pro Leu Gly Gly Ala Ser Ser Leu Gly Glu Ala Xaa Glu Pro Asp 
465                 470                 475                 480 


Pro Leu Arg Ala Arg Arg Gln Pro Ser Ala Asp Gly Ser Lys Pro Trp 
                485                 490                 495     


Trp Trp Ser Tyr Phe Xaa Ser Leu Ser Xaa His Arg Pro Arg Trp Leu 
            500                 505                 510         


Leu Lys Tyr 
        515 


<210> 6817
<211> 641
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<400> 6817
Met Pro Pro Pro Leu Pro Leu Leu Leu Leu Xaa Val Leu Val Val Ala 
1               5                   10                  15      


Ala Ala Arg Pro Gly Cys Glu Phe Glu Arg Asn Pro Ala Ala Xaa Cys 
            20                  25                  30          


Val Asp Leu Gln Leu Arg Xaa Cys Ser Asp Ala Ala Tyr Asn His Xaa 
        35                  40                  45              


Xaa Phe Pro Asn Leu Leu Gln His Arg Ser Trp Glu Val Val Glu Ala 
    50                  55                  60                  


Ser Ser Glu Tyr Ile Leu Leu Ser Val Leu His Gln Leu Leu Glu Gly 
65                  70                  75                  80  


Gln Cys Asn Pro Asp Leu Arg Leu Leu Gly Cys Ala Val Leu Ala Pro 
                85                  90                  95      


Arg Cys Glu Gly Gly Trp Val Arg Arg Pro Cys Arg His Ile Cys Glu 
            100                 105                 110         


Gly Leu Arg Glu Val Cys Gln Pro Ala Phe Asp Ala Ile Asp Met Ala 
        115                 120                 125             


Trp Pro Tyr Phe Leu Asp Cys His Arg Tyr Phe Xaa Arg Glu Asp Glu 
    130                 135                 140                 


Gly Cys Tyr Asp Pro Leu Glu Lys Leu Arg Gly Gly Leu Glu Ala Asp 
145                 150                 155                 160 


Glu Ala Leu Pro Ser Gly Leu Pro Pro Xaa Phe Ile Arg Phe Ser His 
                165                 170                 175     


His Ser Tyr Ala Gln Met Val Arg Val Leu Arg Arg Xaa Ala Ser Arg 
            180                 185                 190         


Cys Ala His Val Ala Arg Xaa Tyr Ser Ile Gly Arg Ser Phe Asp Gly 
        195                 200                 205             


Arg Glu Leu Leu Val Ile Glu Phe Ser Ser Arg Pro Gly Gln His Glu 
    210                 215                 220                 


Leu Met Glu Pro Glu Val Lys Leu Ile Gly Asn Ile His Gly Asn Glu 
225                 230                 235                 240 


Val Ala Gly Arg Glu Met Leu Ile Tyr Leu Ala Gln Tyr Leu Cys Ser 
                245                 250                 255     


Glu Tyr Leu Leu Gly Asn Pro Arg Ile Gln Arg Leu Leu Asn Xaa Xaa 
            260                 265                 270         


Arg Ile His Leu Leu Pro Ser Met Asn Pro Asp Gly Tyr Glu Val Ala 
        275                 280                 285             


Ala Ala Glu Gly Ala Gly Tyr Asn Gly Trp Xaa Ser Gly Arg Gln Asn 
    290                 295                 300                 


Ala Gln Asn Leu Asp Leu Asn Arg Asn Phe Pro Asp Leu Xaa Ser Glu 
305                 310                 315                 320 


Tyr Tyr Arg Leu Ala Glu Xaa Arg Gly Ala Arg Ser Asp His Ile Pro 
                325                 330                 335     


Ile Pro Gln His Tyr Trp Trp Gly Lys Val Ala Pro Glu Xaa Lys Ala 
            340                 345                 350         


Ile Met Lys Trp Met Gln Xaa Ile Pro Phe Val Leu Ser Ala Ser Leu 
        355                 360                 365             


His Gly Gly Asp Leu Val Val Ser Tyr Pro Phe Asp Phe Ser Lys His 
    370                 375                 380                 


Pro Gln Glu Glu Lys Met Phe Ser Pro Xaa Pro Asp Glu Lys Met Phe 
385                 390                 395                 400 


Lys Leu Leu Ser Arg Ala Tyr Ala Asp Val His Pro Met Met Met Asp 
                405                 410                 415     


Arg Ser Glu Asn Arg Cys Gly Gly Asn Phe Leu Lys Arg Gly Ser Ile 
            420                 425                 430         


Ile Asn Gly Ala Asp Trp Tyr Ser Phe Xaa Gly Gly Met Ser Asp Phe 
        435                 440                 445             


Asn Tyr Leu His Xaa Asn Cys Phe Glu Ile Xaa Val Glu Leu Gly Cys 
    450                 455                 460                 


Val Lys Phe Pro Pro Glu Glu Ala Leu Tyr Ile Leu Trp Gln His Asn 
465                 470                 475                 480 


Lys Glu Ser Leu Leu Asn Phe Val Glu Xaa Val His Arg Gly Ile Lys 
                485                 490                 495     


Gly Val Val Xaa Asp Lys Phe Gly Lys Pro Val Lys Asn Ala Arg Ile 
            500                 505                 510         


Ser Val Lys Gly Ile Arg His Asp Ile Xaa Xaa Ala Pro Asp Gly Asp 
        515                 520                 525             


Tyr Trp Arg Leu Leu Pro Pro Gly Ile His Ile Val Ile Ala Gln Ala 
    530                 535                 540                 


Pro Gly Tyr Ala Lys Val Ile Lys Lys Val Ile Ile Pro Ala Arg Met 
545                 550                 555                 560 


Lys Arg Ala Gly Arg Val Asp Phe Ile Leu Gln Pro Leu Gly Met Gly 
                565                 570                 575     


Pro Lys Asn Phe Ile His Gly Leu Arg Arg Xaa Gly Pro His Asp Pro 
            580                 585                 590         


Leu Gly Gly Ala Ser Ser Leu Gly Glu Ala Xaa Glu Pro Asp Pro Leu 
        595                 600                 605             


Arg Ala Arg Arg Gln Pro Ser Ala Asp Gly Ser Lys Pro Trp Trp Trp 
    610                 615                 620                 


Ser Tyr Phe Xaa Ser Leu Ser Xaa His Arg Pro Arg Trp Leu Leu Lys 
625                 630                 635                 640 


Tyr 
    


<210> 6818
<211> 652
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<400> 6818
Met Pro Pro Pro Leu Pro Leu Leu Leu Leu Xaa Val Leu Val Val Ala 
1               5                   10                  15      


Ala Ala Arg Pro Gly Cys Glu Phe Glu Arg Asn Pro Ala Gly Glu Cys 
            20                  25                  30          


His Arg Pro Pro Ala Ala Asp Ser Ala Xaa Cys Val Asp Leu Gln Leu 
        35                  40                  45              


Arg Xaa Cys Ser Asp Ala Ala Tyr Asn His Xaa Xaa Phe Pro Asn Leu 
    50                  55                  60                  


Leu Gln His Arg Ser Trp Glu Val Val Glu Ala Ser Ser Glu Tyr Ile 
65                  70                  75                  80  


Leu Leu Ser Val Leu His Gln Leu Leu Glu Gly Gln Cys Asn Pro Asp 
                85                  90                  95      


Leu Arg Leu Leu Gly Cys Ala Val Leu Ala Pro Arg Cys Glu Gly Gly 
            100                 105                 110         


Trp Val Arg Arg Pro Cys Arg His Ile Cys Glu Gly Leu Arg Glu Val 
        115                 120                 125             


Cys Gln Pro Ala Phe Asp Ala Ile Asp Met Ala Trp Pro Tyr Phe Leu 
    130                 135                 140                 


Asp Cys His Arg Tyr Phe Xaa Arg Glu Asp Glu Gly Cys Tyr Asp Pro 
145                 150                 155                 160 


Leu Glu Lys Leu Arg Gly Gly Leu Glu Ala Asp Glu Ala Leu Pro Ser 
                165                 170                 175     


Gly Leu Pro Pro Xaa Phe Ile Arg Phe Ser His His Ser Tyr Ala Gln 
            180                 185                 190         


Met Val Arg Val Leu Arg Arg Xaa Ala Ser Arg Cys Ala His Val Ala 
        195                 200                 205             


Arg Xaa Tyr Ser Ile Gly Arg Ser Phe Asp Gly Arg Glu Leu Leu Val 
    210                 215                 220                 


Ile Glu Phe Ser Ser Arg Pro Gly Gln His Glu Leu Met Glu Pro Glu 
225                 230                 235                 240 


Val Lys Leu Ile Gly Asn Ile His Gly Asn Glu Val Ala Gly Arg Glu 
                245                 250                 255     


Met Leu Ile Tyr Leu Ala Gln Tyr Leu Cys Ser Glu Tyr Leu Leu Gly 
            260                 265                 270         


Asn Pro Arg Ile Gln Arg Leu Leu Asn Xaa Xaa Arg Ile His Leu Leu 
        275                 280                 285             


Pro Ser Met Asn Pro Asp Gly Tyr Glu Val Ala Ala Ala Glu Gly Ala 
    290                 295                 300                 


Gly Tyr Asn Gly Trp Xaa Ser Gly Arg Gln Asn Ala Gln Asn Leu Asp 
305                 310                 315                 320 


Leu Asn Arg Asn Phe Pro Asp Leu Xaa Ser Glu Tyr Tyr Arg Leu Ala 
                325                 330                 335     


Glu Xaa Arg Gly Ala Arg Ser Asp His Ile Pro Ile Pro Gln His Tyr 
            340                 345                 350         


Trp Trp Gly Lys Val Ala Pro Glu Xaa Lys Ala Ile Met Lys Trp Met 
        355                 360                 365             


Gln Xaa Ile Pro Phe Val Leu Ser Ala Ser Leu His Gly Gly Asp Leu 
    370                 375                 380                 


Val Val Ser Tyr Pro Phe Asp Phe Ser Lys His Pro Gln Glu Glu Lys 
385                 390                 395                 400 


Met Phe Ser Pro Xaa Pro Asp Glu Lys Met Phe Lys Leu Leu Ser Arg 
                405                 410                 415     


Ala Tyr Ala Asp Val His Pro Met Met Met Asp Arg Ser Glu Asn Arg 
            420                 425                 430         


Cys Gly Gly Asn Phe Leu Lys Arg Gly Ser Ile Ile Asn Gly Ala Asp 
        435                 440                 445             


Trp Tyr Ser Phe Xaa Gly Gly Met Ser Asp Phe Asn Tyr Leu His Xaa 
    450                 455                 460                 


Asn Cys Phe Glu Ile Xaa Val Glu Leu Gly Cys Val Lys Phe Pro Pro 
465                 470                 475                 480 


Glu Glu Ala Leu Tyr Ile Leu Trp Gln His Asn Lys Glu Ser Leu Leu 
                485                 490                 495     


Asn Phe Val Glu Xaa Val His Arg Gly Ile Lys Gly Val Val Xaa Asp 
            500                 505                 510         


Lys Phe Gly Lys Pro Val Lys Asn Ala Arg Ile Ser Val Lys Gly Ile 
        515                 520                 525             


Arg His Asp Ile Xaa Xaa Ala Pro Asp Gly Asp Tyr Trp Arg Leu Leu 
    530                 535                 540                 


Pro Pro Gly Ile His Ile Val Ile Ala Gln Ala Pro Gly Tyr Ala Lys 
545                 550                 555                 560 


Val Ile Lys Lys Val Ile Ile Pro Ala Arg Met Lys Arg Ala Gly Arg 
                565                 570                 575     


Val Asp Phe Ile Leu Gln Pro Leu Gly Met Gly Pro Lys Asn Phe Ile 
            580                 585                 590         


His Gly Leu Arg Arg Xaa Gly Pro His Asp Pro Leu Gly Gly Ala Ser 
        595                 600                 605             


Ser Leu Gly Glu Ala Xaa Glu Pro Asp Pro Leu Arg Ala Arg Arg Gln 
    610                 615                 620                 


Pro Ser Ala Asp Gly Ser Lys Pro Trp Trp Trp Ser Tyr Phe Xaa Ser 
625                 630                 635                 640 


Leu Ser Xaa His Arg Pro Arg Trp Leu Leu Lys Tyr 
                645                 650         


<210> 6819
<211> 69
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<400> 6819
Met Pro Pro Pro Leu Pro Leu Leu Leu Leu Xaa Val Leu Val Val Ala 
1               5                   10                  15      


Ala Ala Arg Pro Gly Cys Glu Phe Glu Arg Asn Pro Ala Gly Glu Cys 
            20                  25                  30          


His Arg Pro Pro Ala Ala Asp Ser Gly Xaa Val Pro Gly Pro Pro Trp 
        35                  40                  45              


Leu Leu Phe Cys Arg Arg Ala Ala Ala Pro Xaa Leu Ser Glu His Phe 
    50                  55                  60                  


Arg Gln Leu Asn Pro 
65                  


<210> 6820
<211> 2039
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1071)..(1071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1349)..(1349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1359)..(1359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1367)..(1367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1398)..(1398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1474)..(1474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1479)..(1479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1496)..(1497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1524)..(1524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1536)..(1536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1550)..(1550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1569)..(1569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1588)..(1588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1592)..(1592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1610)..(1610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1612)..(1612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1630)..(1630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1635)..(1635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1662)..(1662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1694)..(1694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1707)..(1707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1786)..(1786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1788)..(1788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1805)..(1805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1812)..(1812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1824)..(1824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1872)..(1872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1892)..(1892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1935)..(1935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1943)..(1943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1966)..(1966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1969)..(1969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1977)..(1977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1981)..(1981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2027)..(2027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2030)..(2030)
<223> Selenocysteine

<400> 6820
Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Xaa Asn Leu Xaa Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Xaa Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Xaa Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Xaa Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Xaa 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Xaa Val Ile Trp Asp Asn Glu Xaa Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Xaa Ile Ala Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Xaa Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Xaa 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Xaa Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Xaa Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Xaa Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Xaa Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Xaa 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Xaa Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Xaa Val Asn Tyr 
        435                 440                 445             


Xaa Cys Asp Pro His Pro Asp Arg Gly Xaa Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Xaa Ile Arg Cys Xaa Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Xaa Gln Xaa Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Xaa Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Xaa Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Xaa Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Xaa Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Xaa Xaa Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Xaa Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Xaa Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Xaa Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Xaa Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Xaa Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Xaa Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Xaa Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Xaa Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Xaa Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Xaa Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Xaa Cys Asp Pro His Pro Asp Arg Gly Xaa Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Xaa Ile Arg Cys Xaa Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Xaa Gln Xaa Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Xaa Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Xaa Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Xaa Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Xaa Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Xaa Xaa Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Xaa Ala His 
    1040                 1045                 1050             


Trp Ser  Xaa Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Xaa Ile Ala Asn Gly  Asp Phe Ile Ser Xaa  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Xaa Tyr Arg Cys  Asn Leu Gly 
    1085                 1090                 1095             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Xaa Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Xaa Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1190                 1195                 1200             


Leu His  Gly Glu His Xaa Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Leu His Cys  Xaa Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1250                 1255                 1260             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1295                 1300                 1305             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1310                 1315                 1320             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Xaa Gly Xaa  Pro Ser Gly 
    1325                 1330                 1335             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Xaa Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Met Xaa Phe  Asn Leu Ile Gly Glu  Ser Xaa Ile 
    1355                 1360                 1365             


Arg Cys  Xaa Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Ala Gly His  Cys Lys Xaa 
    1385                 1390                 1395             


Pro Glu  Gln Phe Pro Phe Ala  Ser Pro Xaa Ile Pro  Ile Asn Asp 
    1400                 1405                 1410             


Phe Glu  Phe Pro Val Gly Xaa  Ser Leu Asn Tyr Glu  Cys Arg Pro 
    1415                 1420                 1425             


Gly Tyr  Phe Gly Lys Met Phe  Ser Ile Ser Cys Leu  Glu Asn Leu 
    1430                 1435                 1440             


Val Trp  Ser Ser Val Glu Asp  Asn Cys Arg Arg Lys  Ser Cys Gly 
    1445                 1450                 1455             


Pro Pro  Pro Glu Pro Phe Asn  Gly Met Val His Ile  Asn Xaa Asp 
    1460                 1465                 1470             


Xaa Gln  Phe Gly Ser Xaa Val  Asn Tyr Ser Cys Asn  Glu Gly Phe 
    1475                 1480                 1485             


Arg Leu  Ile Gly Ser Pro Ser  Xaa Xaa Cys Leu Val  Ser Gly Asn 
    1490                 1495                 1500             


Asn Val  Xaa Trp Asp Lys Lys  Ala Pro Ile Cys Glu  Ile Ile Ser 
    1505                 1510                 1515             


Cys Glu  Pro Pro Pro Xaa Ile  Ser Asn Gly Asp Phe  Tyr Ser Asn 
    1520                 1525                 1530             


Asn Arg  Xaa Ser Phe His Asn  Gly Xaa Val Val Xaa  Tyr Gln Cys 
    1535                 1540                 1545             


His Xaa  Gly Pro Asp Gly Glu  Gln Leu Phe Glu Leu  Val Gly Glu 
    1550                 1555                 1560             


Arg Ser  Ile Tyr Cys Xaa Ser  Lys Asp Asp Gln Val  Gly Val Trp 
    1565                 1570                 1575             


Ser Ser  Pro Pro Pro Arg Cys  Ile Ser Xaa Asn Lys  Cys Xaa Ala 
    1580                 1585                 1590             


Pro Glu  Val Glu Asn Ala Ile  Arg Val Pro Gly Asn  Arg Ser Phe 
    1595                 1600                 1605             


Phe Xaa  Leu Xaa Glu Ile Ile  Arg Phe Arg Cys Gln  Pro Gly Phe 
    1610                 1615                 1620             


Val Met  Val Gly Ser His Xaa  Val Gln Cys Gln Xaa  Asn Gly Arg 
    1625                 1630                 1635             


Trp Gly  Pro Lys Leu Pro His  Cys Ser Arg Val Cys  Gln Pro Pro 
    1640                 1645                 1650             


Pro Glu  Ile Leu His Gly Glu  His Xaa Leu Ser His  Gln Asp Asn 
    1655                 1660                 1665             


Phe Ser  Pro Gly Gln Glu Val  Phe Tyr Ser Cys Glu  Pro Ser Tyr 
    1670                 1675                 1680             


Asp Leu  Arg Gly Ala Ala Ser  Leu His Cys Xaa Pro  Gln Gly Asp 
    1685                 1690                 1695             


Trp Ser  Pro Glu Ala Pro Arg  Cys Xaa Val Lys Ser  Cys Asp Asp 
    1700                 1705                 1710             


Phe Leu  Gly Gln Leu Pro His  Gly Arg Val Leu Leu  Pro Leu Asn 
    1715                 1720                 1725             


Leu Gln  Leu Gly Ala Lys Val  Ser Phe Val Cys Asp  Glu Gly Phe 
    1730                 1735                 1740             


Arg Leu  Lys Gly Arg Ser Ala  Ser His Cys Val Leu  Ala Gly Met 
    1745                 1750                 1755             


Lys Ala  Leu Trp Asn Ser Ser  Val Pro Val Cys Glu  Gln Ile Phe 
    1760                 1765                 1770             


Cys Pro  Asn Pro Pro Ala Ile  Leu Asn Gly Arg His  Xaa Gly Xaa 
    1775                 1780                 1785             


Pro Phe  Gly Asp Ile Pro Tyr  Gly Lys Glu Ile Ser  Tyr Ala Cys 
    1790                 1795                 1800             


Asp Xaa  His Pro Asp Arg Gly  Met Xaa Phe Asn Leu  Ile Gly Glu 
    1805                 1810                 1815             


Ser Ser  Ile Arg Cys Xaa Ser  Asp Pro Gln Gly Asn  Gly Val Trp 
    1820                 1825                 1830             


Ser Ser  Pro Ala Pro Arg Cys  Glu Leu Ser Val Pro  Ala Ala Cys 
    1835                 1840                 1845             


Pro His  Pro Pro Lys Ile Gln  Asn Gly His Tyr Ile  Gly Gly His 
    1850                 1855                 1860             


Val Ser  Leu Tyr Leu Pro Gly  Met Xaa Ile Ser Tyr  Ile Cys Asp 
    1865                 1870                 1875             


Pro Gly  Tyr Leu Leu Val Gly  Lys Gly Phe Ile Phe  Cys Xaa Asp 
    1880                 1885                 1890             


Gln Gly  Ile Trp Ser Gln Leu  Asp His Tyr Cys Lys  Glu Val Asn 
    1895                 1900                 1905             


Cys Ser  Phe Pro Leu Phe Met  Asn Gly Ile Ser Lys  Glu Leu Glu 
    1910                 1915                 1920             


Met Lys  Lys Val Tyr His Tyr  Gly Asp Tyr Val Xaa  Leu Lys Cys 
    1925                 1930                 1935             


Glu Asp  Gly Tyr Xaa Leu Glu  Gly Ser Pro Trp Ser  Gln Cys Gln 
    1940                 1945                 1950             


Ala Asp  Asp Arg Trp Asp Pro  Pro Leu Ala Lys Cys  Xaa Ser Arg 
    1955                 1960                 1965             


Xaa His  Asp Ala Leu Ile Val  Gly Xaa Leu Ser Gly  Xaa Ile Phe 
    1970                 1975                 1980             


Phe Ile  Leu Leu Ile Ile Phe  Leu Ser Trp Ile Ile  Leu Lys His 
    1985                 1990                 1995             


Arg Lys  Gly Asn Asn Ala His  Glu Asn Pro Lys Glu  Val Ala Ile 
    2000                 2005                 2010             


His Leu  His Ser Gln Gly Gly  Ser Ser Val His Pro  Arg Xaa Leu 
    2015                 2020                 2025             


Gln Xaa  Asn Glu Glu Asn Ser  Arg Val Leu Pro 
    2030                 2035                 


<210> 6821
<211> 604
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(583)
<223> Selenocysteine

<400> 6821
Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Xaa Asn Leu Xaa Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Xaa Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Xaa Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Xaa Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Xaa 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Xaa Val Ile Trp Asp Asn Glu Xaa Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Xaa Ile Xaa Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Xaa Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Xaa 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Xaa Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Xaa Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Xaa Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Xaa Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Xaa 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Xaa Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Xaa Val Asn Tyr 
        435                 440                 445             


Xaa Cys Asp Pro His Pro Asp Arg Gly Xaa Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Xaa Ile Arg Cys Xaa Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Xaa Gln Xaa Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Xaa Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Xaa Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Xaa Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Xaa Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Xaa Xaa Gly Ser Leu Ser Ser Pro Arg Ser Phe 
            580                 585                 590         


Ser Val Cys Gln Val Glu Asn Pro Asn Gln Cys Ile 
        595                 600                 


<210> 6822
<211> 2039
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1071)..(1071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1349)..(1349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1359)..(1359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1367)..(1367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1398)..(1398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1474)..(1474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1479)..(1479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1496)..(1497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1524)..(1524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1536)..(1536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1550)..(1550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1569)..(1569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1588)..(1588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1592)..(1592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1610)..(1610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1612)..(1612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1630)..(1630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1635)..(1635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1662)..(1662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1694)..(1694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1707)..(1707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1786)..(1786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1788)..(1788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1805)..(1805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1812)..(1812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1824)..(1824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1872)..(1872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1892)..(1892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1935)..(1935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1943)..(1943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1966)..(1966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1969)..(1969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1977)..(1977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1981)..(1981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2027)..(2027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2030)..(2030)
<223> Selenocysteine

<400> 6822
Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Xaa Asn Leu Xaa Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Xaa Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Xaa Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Xaa Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Xaa 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Xaa Val Ile Trp Asp Asn Glu Xaa Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Xaa Ile Xaa Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Xaa Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Xaa 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Xaa Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Xaa Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Xaa Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Xaa Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Xaa 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Xaa Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Xaa Val Asn Tyr 
        435                 440                 445             


Xaa Cys Asp Pro His Pro Asp Arg Gly Xaa Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Xaa Ile Arg Cys Xaa Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Xaa Gln Xaa Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Xaa Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Xaa Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Xaa Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Xaa Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Xaa Xaa Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Xaa Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Xaa Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Xaa Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Xaa Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Xaa Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Xaa Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Xaa Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Xaa Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Xaa Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Xaa Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Xaa Val 
                885                 890                 895     


Asn Tyr Xaa Cys Asp Pro His Pro Asp Arg Gly Xaa Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Xaa Ile Arg Cys Xaa Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Xaa Gln Xaa Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Xaa Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Xaa Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Xaa Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Xaa Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Xaa Xaa Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Xaa Ala His 
    1040                 1045                 1050             


Trp Ser  Xaa Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Xaa Ile Ala Asn Gly  Asp Phe Ile Ser Xaa  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Xaa Tyr Arg Cys  Asn Leu Gly 
    1085                 1090                 1095             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Xaa Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Xaa Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1190                 1195                 1200             


Leu His  Gly Glu His Xaa Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Leu His Cys  Xaa Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1250                 1255                 1260             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1295                 1300                 1305             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1310                 1315                 1320             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Xaa Gly Xaa  Pro Ser Gly 
    1325                 1330                 1335             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Xaa Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Met Xaa Phe  Asn Leu Ile Gly Glu  Ser Xaa Ile 
    1355                 1360                 1365             


Arg Cys  Xaa Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Ala Gly His  Cys Lys Xaa 
    1385                 1390                 1395             


Pro Glu  Gln Phe Pro Phe Ala  Ser Pro Xaa Ile Pro  Ile Asn Asp 
    1400                 1405                 1410             


Phe Glu  Phe Pro Val Gly Xaa  Ser Leu Asn Tyr Glu  Cys Arg Pro 
    1415                 1420                 1425             


Gly Tyr  Phe Gly Lys Met Phe  Ser Ile Ser Cys Leu  Glu Asn Leu 
    1430                 1435                 1440             


Val Trp  Ser Ser Val Glu Asp  Asn Cys Arg Arg Lys  Ser Cys Gly 
    1445                 1450                 1455             


Pro Pro  Pro Glu Pro Phe Asn  Gly Met Val His Ile  Asn Xaa Asp 
    1460                 1465                 1470             


Xaa Gln  Phe Gly Ser Xaa Val  Asn Tyr Ser Cys Asn  Glu Gly Phe 
    1475                 1480                 1485             


Arg Leu  Ile Gly Ser Pro Ser  Xaa Xaa Cys Leu Val  Ser Gly Asn 
    1490                 1495                 1500             


Asn Val  Xaa Trp Asp Lys Lys  Ala Pro Ile Cys Glu  Ile Ile Ser 
    1505                 1510                 1515             


Cys Glu  Pro Pro Pro Xaa Ile  Ser Asn Gly Asp Phe  Tyr Ser Asn 
    1520                 1525                 1530             


Asn Arg  Xaa Ser Phe His Asn  Gly Xaa Val Val Xaa  Tyr Gln Cys 
    1535                 1540                 1545             


His Xaa  Gly Pro Asp Gly Glu  Gln Leu Phe Glu Leu  Val Gly Glu 
    1550                 1555                 1560             


Arg Ser  Ile Tyr Cys Xaa Ser  Lys Asp Asp Gln Val  Gly Val Trp 
    1565                 1570                 1575             


Ser Ser  Pro Pro Pro Arg Cys  Ile Ser Xaa Asn Lys  Cys Xaa Ala 
    1580                 1585                 1590             


Pro Glu  Val Glu Asn Ala Ile  Arg Val Pro Gly Asn  Arg Ser Phe 
    1595                 1600                 1605             


Phe Xaa  Leu Xaa Glu Ile Ile  Arg Phe Arg Cys Gln  Pro Gly Phe 
    1610                 1615                 1620             


Val Met  Val Gly Ser His Xaa  Val Gln Cys Gln Xaa  Asn Gly Arg 
    1625                 1630                 1635             


Trp Gly  Pro Lys Leu Pro His  Cys Ser Arg Val Cys  Gln Pro Pro 
    1640                 1645                 1650             


Pro Glu  Ile Leu His Gly Glu  His Xaa Leu Ser His  Gln Asp Asn 
    1655                 1660                 1665             


Phe Ser  Pro Gly Gln Glu Val  Phe Tyr Ser Cys Glu  Pro Ser Tyr 
    1670                 1675                 1680             


Asp Leu  Arg Gly Ala Ala Ser  Leu His Cys Xaa Pro  Gln Gly Asp 
    1685                 1690                 1695             


Trp Ser  Pro Glu Ala Pro Arg  Cys Xaa Val Lys Ser  Cys Asp Asp 
    1700                 1705                 1710             


Phe Leu  Gly Gln Leu Pro His  Gly Arg Val Leu Leu  Pro Leu Asn 
    1715                 1720                 1725             


Leu Gln  Leu Gly Ala Lys Val  Ser Phe Val Cys Asp  Glu Gly Phe 
    1730                 1735                 1740             


Arg Leu  Lys Gly Arg Ser Ala  Ser His Cys Val Leu  Ala Gly Met 
    1745                 1750                 1755             


Lys Ala  Leu Trp Asn Ser Ser  Val Pro Val Cys Glu  Gln Ile Phe 
    1760                 1765                 1770             


Cys Pro  Asn Pro Pro Ala Ile  Leu Asn Gly Arg His  Xaa Gly Xaa 
    1775                 1780                 1785             


Pro Phe  Gly Asp Ile Pro Tyr  Gly Lys Glu Ile Ser  Tyr Ala Cys 
    1790                 1795                 1800             


Asp Xaa  His Pro Asp Arg Gly  Met Xaa Phe Asn Leu  Ile Gly Glu 
    1805                 1810                 1815             


Ser Ser  Ile Arg Cys Xaa Ser  Asp Pro Gln Gly Asn  Gly Val Trp 
    1820                 1825                 1830             


Ser Ser  Pro Ala Pro Arg Cys  Glu Leu Ser Val Pro  Ala Ala Cys 
    1835                 1840                 1845             


Pro His  Pro Pro Lys Ile Gln  Asn Gly His Tyr Ile  Gly Gly His 
    1850                 1855                 1860             


Val Ser  Leu Tyr Leu Pro Gly  Met Xaa Ile Ser Tyr  Ile Cys Asp 
    1865                 1870                 1875             


Pro Gly  Tyr Leu Leu Val Gly  Lys Gly Phe Ile Phe  Cys Xaa Asp 
    1880                 1885                 1890             


Gln Gly  Ile Trp Ser Gln Leu  Asp His Tyr Cys Lys  Glu Val Asn 
    1895                 1900                 1905             


Cys Ser  Phe Pro Leu Phe Met  Asn Gly Ile Ser Lys  Glu Leu Glu 
    1910                 1915                 1920             


Met Lys  Lys Val Tyr His Tyr  Gly Asp Tyr Val Xaa  Leu Lys Cys 
    1925                 1930                 1935             


Glu Asp  Gly Tyr Xaa Leu Glu  Gly Ser Pro Trp Ser  Gln Cys Gln 
    1940                 1945                 1950             


Ala Asp  Asp Arg Trp Asp Pro  Pro Leu Ala Lys Cys  Xaa Ser Arg 
    1955                 1960                 1965             


Xaa His  Asp Ala Leu Ile Val  Gly Xaa Leu Ser Gly  Xaa Ile Phe 
    1970                 1975                 1980             


Phe Ile  Leu Leu Ile Ile Phe  Leu Ser Trp Ile Ile  Leu Lys His 
    1985                 1990                 1995             


Arg Lys  Gly Asn Asn Ala His  Glu Asn Pro Lys Glu  Val Ala Ile 
    2000                 2005                 2010             


His Leu  His Ser Gln Gly Gly  Ser Ser Val His Pro  Arg Xaa Leu 
    2015                 2020                 2025             


Gln Xaa  Asn Glu Glu Asn Ser  Arg Val Leu Pro 
    2030                 2035                 


<210> 6823
<211> 2039
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1071)..(1071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1349)..(1349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1359)..(1359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1367)..(1367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1398)..(1398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1472)..(1472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1474)..(1474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1479)..(1479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1496)..(1497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1524)..(1524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1536)..(1536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1550)..(1550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1569)..(1569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1588)..(1588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1592)..(1592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1610)..(1610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1612)..(1612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1630)..(1630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1635)..(1635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1662)..(1662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1694)..(1694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1707)..(1707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1786)..(1786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1788)..(1788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1805)..(1805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1812)..(1812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1824)..(1824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1872)..(1872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1892)..(1892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1935)..(1935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1943)..(1943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1966)..(1966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1969)..(1969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1977)..(1977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1981)..(1981)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2027)..(2027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2030)..(2030)
<223> Selenocysteine

<400> 6823
Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Xaa Asn Leu Xaa Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Xaa Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Xaa Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Xaa Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Xaa 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Xaa Val Ile Trp Asp Asn Glu Xaa Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Xaa Ile Xaa Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Xaa Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Xaa 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Xaa Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Xaa Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Xaa Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Xaa Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Xaa 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Xaa Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Xaa Val Asn Tyr 
        435                 440                 445             


Xaa Cys Asp Pro His Pro Asp Arg Gly Xaa Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Xaa Ile Arg Cys Xaa Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Xaa Gln Xaa Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Xaa Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Xaa Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Xaa Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Xaa Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Xaa Xaa Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Xaa Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Xaa Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Xaa Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Xaa Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Xaa Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Xaa Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Xaa Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Xaa Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Xaa Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Xaa Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Xaa Cys Asp Pro His Pro Asp Arg Gly Xaa Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Xaa Ile Arg Cys Xaa Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Xaa Gln Xaa Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Xaa Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Xaa Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Xaa Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Xaa Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Xaa Xaa Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Xaa Ala His 
    1040                 1045                 1050             


Trp Ser  Xaa Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Xaa Ile Ala Asn Gly  Asp Phe Ile Ser Xaa  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Xaa Tyr Arg Cys  Asn Leu Gly 
    1085                 1090                 1095             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Xaa Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Xaa Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1190                 1195                 1200             


Leu His  Gly Glu His Xaa Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Leu His Cys  Xaa Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1250                 1255                 1260             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1295                 1300                 1305             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1310                 1315                 1320             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Xaa Gly Xaa  Pro Ser Gly 
    1325                 1330                 1335             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Xaa Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Met Xaa Phe  Asn Leu Ile Gly Glu  Ser Xaa Ile 
    1355                 1360                 1365             


Arg Cys  Xaa Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Ala Gly His  Cys Lys Xaa 
    1385                 1390                 1395             


Pro Glu  Gln Phe Pro Phe Ala  Ser Pro Xaa Ile Pro  Ile Asn Asp 
    1400                 1405                 1410             


Phe Glu  Phe Pro Val Gly Xaa  Ser Leu Asn Tyr Glu  Cys Arg Pro 
    1415                 1420                 1425             


Gly Tyr  Phe Gly Lys Met Phe  Ser Ile Ser Cys Leu  Glu Asn Leu 
    1430                 1435                 1440             


Val Trp  Ser Ser Val Glu Asp  Asn Cys Arg Arg Lys  Ser Cys Gly 
    1445                 1450                 1455             


Pro Pro  Pro Glu Pro Phe Asn  Gly Met Val His Ile  Asn Xaa Asp 
    1460                 1465                 1470             


Xaa Gln  Phe Gly Ser Xaa Val  Asn Tyr Ser Cys Asn  Glu Gly Phe 
    1475                 1480                 1485             


Arg Leu  Ile Gly Ser Pro Ser  Xaa Xaa Cys Leu Val  Ser Gly Asn 
    1490                 1495                 1500             


Asn Val  Xaa Trp Asp Lys Lys  Ala Pro Ile Cys Glu  Ile Ile Ser 
    1505                 1510                 1515             


Cys Glu  Pro Pro Pro Xaa Ile  Ser Asn Gly Asp Phe  Tyr Ser Asn 
    1520                 1525                 1530             


Asn Arg  Xaa Ser Phe His Asn  Gly Xaa Val Val Xaa  Tyr Gln Cys 
    1535                 1540                 1545             


His Xaa  Gly Pro Asp Gly Glu  Gln Leu Phe Glu Leu  Val Gly Glu 
    1550                 1555                 1560             


Arg Ser  Ile Tyr Cys Xaa Ser  Lys Asp Asp Gln Val  Gly Val Trp 
    1565                 1570                 1575             


Ser Ser  Pro Pro Pro Arg Cys  Ile Ser Xaa Asn Lys  Cys Xaa Ala 
    1580                 1585                 1590             


Pro Glu  Val Glu Asn Ala Ile  Arg Val Pro Gly Asn  Arg Ser Phe 
    1595                 1600                 1605             


Phe Xaa  Leu Xaa Glu Ile Ile  Arg Phe Arg Cys Gln  Pro Gly Phe 
    1610                 1615                 1620             


Val Met  Val Gly Ser His Xaa  Val Gln Cys Gln Xaa  Asn Gly Arg 
    1625                 1630                 1635             


Trp Gly  Pro Lys Leu Pro His  Cys Ser Arg Val Cys  Gln Pro Pro 
    1640                 1645                 1650             


Pro Glu  Ile Leu His Gly Glu  His Xaa Leu Ser His  Gln Asp Asn 
    1655                 1660                 1665             


Phe Ser  Pro Gly Gln Glu Val  Phe Tyr Ser Cys Glu  Pro Ser Tyr 
    1670                 1675                 1680             


Asp Leu  Arg Gly Ala Ala Ser  Leu His Cys Xaa Pro  Gln Gly Asp 
    1685                 1690                 1695             


Trp Ser  Pro Glu Ala Pro Arg  Cys Xaa Val Lys Ser  Cys Asp Asp 
    1700                 1705                 1710             


Phe Leu  Gly Gln Leu Pro His  Gly Arg Val Leu Leu  Pro Leu Asn 
    1715                 1720                 1725             


Leu Gln  Leu Gly Ala Lys Val  Ser Phe Val Cys Asp  Glu Gly Phe 
    1730                 1735                 1740             


Arg Leu  Lys Gly Arg Ser Ala  Ser His Cys Val Leu  Ala Gly Met 
    1745                 1750                 1755             


Lys Ala  Leu Trp Asn Ser Ser  Val Pro Val Cys Glu  Gln Ile Phe 
    1760                 1765                 1770             


Cys Pro  Asn Pro Pro Ala Ile  Leu Asn Gly Arg His  Xaa Gly Xaa 
    1775                 1780                 1785             


Pro Phe  Gly Asp Ile Pro Tyr  Gly Lys Glu Ile Ser  Tyr Ala Cys 
    1790                 1795                 1800             


Asp Xaa  His Pro Asp Arg Gly  Met Xaa Phe Asn Leu  Ile Gly Glu 
    1805                 1810                 1815             


Ser Ser  Ile Arg Cys Xaa Ser  Asp Pro Gln Gly Asn  Gly Val Trp 
    1820                 1825                 1830             


Ser Ser  Pro Ala Pro Arg Cys  Glu Leu Ser Val Pro  Ala Ala Cys 
    1835                 1840                 1845             


Pro His  Pro Pro Lys Ile Gln  Asn Gly His Tyr Ile  Gly Gly His 
    1850                 1855                 1860             


Val Ser  Leu Tyr Leu Pro Gly  Met Xaa Ile Ser Tyr  Ile Cys Asp 
    1865                 1870                 1875             


Pro Gly  Tyr Leu Leu Val Gly  Lys Gly Phe Ile Phe  Cys Xaa Asp 
    1880                 1885                 1890             


Gln Gly  Ile Trp Ser Gln Leu  Asp His Tyr Cys Lys  Glu Val Asn 
    1895                 1900                 1905             


Cys Ser  Phe Pro Leu Phe Met  Asn Gly Ile Ser Lys  Glu Leu Glu 
    1910                 1915                 1920             


Met Lys  Lys Val Tyr His Tyr  Gly Asp Tyr Val Xaa  Leu Lys Cys 
    1925                 1930                 1935             


Glu Asp  Gly Tyr Xaa Leu Glu  Gly Ser Pro Trp Ser  Gln Cys Gln 
    1940                 1945                 1950             


Ala Asp  Asp Arg Trp Asp Pro  Pro Leu Ala Lys Cys  Xaa Ser Arg 
    1955                 1960                 1965             


Xaa His  Asp Ala Leu Ile Val  Gly Xaa Leu Ser Gly  Xaa Ile Phe 
    1970                 1975                 1980             


Phe Ile  Leu Leu Ile Ile Phe  Leu Ser Trp Ile Ile  Leu Lys His 
    1985                 1990                 1995             


Arg Lys  Gly Asn Asn Ala His  Glu Asn Pro Lys Glu  Val Ala Ile 
    2000                 2005                 2010             


His Leu  His Ser Gln Gly Gly  Ser Ser Val His Pro  Arg Xaa Leu 
    2015                 2020                 2025             


Gln Xaa  Asn Glu Glu Asn Ser  Arg Val Leu Pro 
    2030                 2035                 


<210> 6824
<211> 2489
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (967)..(967)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (985)..(985)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1019)..(1019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1071)..(1071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1080)..(1080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1252)..(1252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1333)..(1333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1349)..(1349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1367)..(1367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1371)..(1371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1406)..(1406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1408)..(1408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1417)..(1417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1435)..(1435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1456)..(1456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1469)..(1469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1482)..(1483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1501)..(1501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1506)..(1506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1521)..(1521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1530)..(1530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1542)..(1542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1566)..(1566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1589)..(1589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1659)..(1659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1691)..(1691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1783)..(1783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1785)..(1785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1799)..(1799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1809)..(1809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1817)..(1817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1821)..(1821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1848)..(1848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1858)..(1858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1870)..(1870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1922)..(1922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1924)..(1924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1929)..(1929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1946)..(1947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1956)..(1956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1974)..(1974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1986)..(1986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1992)..(1992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1995)..(1995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2000)..(2000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2019)..(2019)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2038)..(2038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2042)..(2042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2060)..(2060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2062)..(2062)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2080)..(2080)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2085)..(2085)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2112)..(2112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2144)..(2144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2157)..(2157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2236)..(2236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2238)..(2238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2255)..(2255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2262)..(2262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2274)..(2274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2322)..(2322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2342)..(2342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2385)..(2385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2393)..(2393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2416)..(2416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2419)..(2419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2427)..(2427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2431)..(2431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2477)..(2477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2480)..(2480)
<223> Selenocysteine

<400> 6824
Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Xaa Asn Leu Xaa Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Xaa Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Xaa Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Xaa Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Xaa 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Xaa Val Ile Trp Asp Asn Glu Xaa Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Xaa Ile Xaa Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Xaa Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Xaa 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Xaa Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Xaa Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Xaa Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Xaa Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Xaa 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Xaa Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Xaa Val Asn Tyr 
        435                 440                 445             


Xaa Cys Asp Pro His Pro Asp Arg Gly Xaa Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Xaa Ile Arg Cys Xaa Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Xaa Gln Xaa Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Xaa Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Xaa Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Xaa Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Xaa Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Xaa Xaa Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Xaa Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Xaa Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Xaa Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Xaa Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Xaa Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Xaa Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Xaa Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Xaa Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Xaa Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Xaa Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Xaa Val 
                885                 890                 895     


Asn Tyr Xaa Cys Asp Pro His Pro Asp Arg Gly Xaa Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Xaa Ile Arg Cys Xaa Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Xaa Gln Xaa Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Xaa Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Xaa Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Xaa Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Xaa Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Xaa Xaa Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Ala Ala His 
    1040                 1045                 1050             


Trp Ser  Xaa Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Xaa Ile Ala Asn Gly  Asp Phe Ile Ser Xaa  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Xaa Tyr Arg Cys  Asn Pro Gly 
    1085                 1090                 1095             


Ser Gly  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Xaa Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Xaa Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Asp Val 
    1190                 1195                 1200             


Leu His  Ala Glu Arg Xaa Gln  Arg Asp Lys Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Met Arg Cys  Xaa Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Ala Ala  Pro Xaa Cys Glu Val  Lys Ser Cys Asp Asp  Phe Met Gly 
    1250                 1255                 1260             


Gln Leu  Leu Asn Gly Arg Val  Leu Phe Pro Val Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Asp Phe Val  Cys Asp Glu Gly Phe  Gln Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Ala Ser Tyr Cys  Val Leu Ala Gly Met  Glu Ser Leu 
    1295                 1300                 1305             


Trp Asn  Ser Ser Val Pro Val  Cys Glu Gln Ile Phe  Cys Pro Ser 
    1310                 1315                 1320             


Pro Pro  Val Ile Pro Asn Gly  Arg His Xaa Gly Lys  Pro Leu Glu 
    1325                 1330                 1335             


Val Phe  Pro Phe Gly Lys Ala  Val Asn Tyr Xaa Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Xaa Ser Phe  Asp Leu Ile Gly Glu  Ser Xaa Ile 
    1355                 1360                 1365             


Arg Cys  Xaa Ser Asp Pro Gln  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Gly Ile Leu  Gly His Cys Gln Ala  Pro Asp His 
    1385                 1390                 1395             


Phe Leu  Phe Ala Lys Leu Lys  Xaa Gln Xaa Asn Ala  Ser Asp Phe 
    1400                 1405                 1410             


Pro Ile  Gly Xaa Ser Leu Lys  Tyr Glu Cys Arg Pro  Glu Tyr Tyr 
    1415                 1420                 1425             


Gly Arg  Pro Phe Ser Ile Xaa  Cys Leu Asp Asn Leu  Val Trp Ser 
    1430                 1435                 1440             


Ser Pro  Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Xaa Pro Pro 
    1445                 1450                 1455             


Asp Pro  Val Asn Gly Met Val  His Val Ile Xaa Asp  Ile Gln Val 
    1460                 1465                 1470             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Xaa Xaa Gly His  Arg Leu Ile 
    1475                 1480                 1485             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Xaa Ala His 
    1490                 1495                 1500             


Trp Ser  Xaa Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1505                 1510                 1515             


Pro Pro  Xaa Ile Ala Asn Gly  Asp Phe Ile Ser Xaa  Asn Arg Glu 
    1520                 1525                 1530             


Asn Phe  His Tyr Gly Ser Val  Val Xaa Tyr Arg Cys  Asn Leu Gly 
    1535                 1540                 1545             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1550                 1555                 1560             


Tyr Cys  Xaa Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1565                 1570                 1575             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Xaa Pro  Pro Asn Val 
    1580                 1585                 1590             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1595                 1600                 1605             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1610                 1615                 1620             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1625                 1630                 1635             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1640                 1645                 1650             


Leu His  Gly Glu His Xaa Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1655                 1660                 1665             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1670                 1675                 1680             


Gly Ala  Ala Ser Leu His Cys  Xaa Pro Gln Gly Asp  Trp Ser Pro 
    1685                 1690                 1695             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1700                 1705                 1710             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1715                 1720                 1725             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1730                 1735                 1740             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1745                 1750                 1755             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1760                 1765                 1770             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Xaa Gly Xaa  Pro Ser Gly 
    1775                 1780                 1785             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Xaa Cys  Asp Pro His 
    1790                 1795                 1800             


Pro Asp  Arg Gly Met Xaa Phe  Asn Leu Ile Gly Glu  Ser Xaa Ile 
    1805                 1810                 1815             


Arg Cys  Xaa Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1820                 1825                 1830             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Ala Gly His  Cys Lys Xaa 
    1835                 1840                 1845             


Pro Glu  Gln Phe Pro Phe Ala  Ser Pro Xaa Ile Pro  Ile Asn Asp 
    1850                 1855                 1860             


Phe Glu  Phe Pro Val Gly Xaa  Ser Leu Asn Tyr Glu  Cys Arg Pro 
    1865                 1870                 1875             


Gly Tyr  Phe Gly Lys Met Phe  Ser Ile Ser Cys Leu  Glu Asn Leu 
    1880                 1885                 1890             


Val Trp  Ser Ser Val Glu Asp  Asn Cys Arg Arg Lys  Ser Cys Gly 
    1895                 1900                 1905             


Pro Pro  Pro Glu Pro Phe Asn  Gly Met Val His Ile  Asn Xaa Asp 
    1910                 1915                 1920             


Xaa Gln  Phe Gly Ser Xaa Val  Asn Tyr Ser Cys Asn  Glu Gly Phe 
    1925                 1930                 1935             


Arg Leu  Ile Gly Ser Pro Ser  Xaa Xaa Cys Leu Val  Ser Gly Asn 
    1940                 1945                 1950             


Asn Val  Xaa Trp Asp Lys Lys  Ala Pro Ile Cys Glu  Ile Ile Ser 
    1955                 1960                 1965             


Cys Glu  Pro Pro Pro Xaa Ile  Ser Asn Gly Asp Phe  Tyr Ser Asn 
    1970                 1975                 1980             


Asn Arg  Xaa Ser Phe His Asn  Gly Xaa Val Val Xaa  Tyr Gln Cys 
    1985                 1990                 1995             


His Xaa  Gly Pro Asp Gly Glu  Gln Leu Phe Glu Leu  Val Gly Glu 
    2000                 2005                 2010             


Arg Ser  Ile Tyr Cys Xaa Ser  Lys Asp Asp Gln Val  Gly Val Trp 
    2015                 2020                 2025             


Ser Ser  Pro Pro Pro Arg Cys  Ile Ser Xaa Asn Lys  Cys Xaa Ala 
    2030                 2035                 2040             


Pro Glu  Val Glu Asn Ala Ile  Arg Val Pro Gly Asn  Arg Ser Phe 
    2045                 2050                 2055             


Phe Xaa  Leu Xaa Glu Ile Ile  Arg Phe Arg Cys Gln  Pro Gly Phe 
    2060                 2065                 2070             


Val Met  Val Gly Ser His Xaa  Val Gln Cys Gln Xaa  Asn Gly Arg 
    2075                 2080                 2085             


Trp Gly  Pro Lys Leu Pro His  Cys Ser Arg Val Cys  Gln Pro Pro 
    2090                 2095                 2100             


Pro Glu  Ile Leu His Gly Glu  His Xaa Leu Ser His  Gln Asp Asn 
    2105                 2110                 2115             


Phe Ser  Pro Gly Gln Glu Val  Phe Tyr Ser Cys Glu  Pro Ser Tyr 
    2120                 2125                 2130             


Asp Leu  Arg Gly Ala Ala Ser  Leu His Cys Xaa Pro  Gln Gly Asp 
    2135                 2140                 2145             


Trp Ser  Pro Glu Ala Pro Arg  Cys Xaa Val Lys Ser  Cys Asp Asp 
    2150                 2155                 2160             


Phe Leu  Gly Gln Leu Pro His  Gly Arg Val Leu Leu  Pro Leu Asn 
    2165                 2170                 2175             


Leu Gln  Leu Gly Ala Lys Val  Ser Phe Val Cys Asp  Glu Gly Phe 
    2180                 2185                 2190             


Arg Leu  Lys Gly Arg Ser Ala  Ser His Cys Val Leu  Ala Gly Met 
    2195                 2200                 2205             


Lys Ala  Leu Trp Asn Ser Ser  Val Pro Val Cys Glu  Gln Ile Phe 
    2210                 2215                 2220             


Cys Pro  Asn Pro Pro Ala Ile  Leu Asn Gly Arg His  Xaa Gly Xaa 
    2225                 2230                 2235             


Pro Phe  Gly Asp Ile Pro Tyr  Gly Lys Glu Ile Ser  Tyr Ala Cys 
    2240                 2245                 2250             


Asp Xaa  His Pro Asp Arg Gly  Met Xaa Phe Asn Leu  Ile Gly Glu 
    2255                 2260                 2265             


Ser Ser  Ile Arg Cys Xaa Ser  Asp Pro Gln Gly Asn  Gly Val Trp 
    2270                 2275                 2280             


Ser Ser  Pro Ala Pro Arg Cys  Glu Leu Ser Val Pro  Ala Ala Cys 
    2285                 2290                 2295             


Pro His  Pro Pro Lys Ile Gln  Asn Gly His Tyr Ile  Gly Gly His 
    2300                 2305                 2310             


Val Ser  Leu Tyr Leu Pro Gly  Met Xaa Ile Ser Tyr  Ile Cys Asp 
    2315                 2320                 2325             


Pro Gly  Tyr Leu Leu Val Gly  Lys Gly Phe Ile Phe  Cys Xaa Asp 
    2330                 2335                 2340             


Gln Gly  Ile Trp Ser Gln Leu  Asp His Tyr Cys Lys  Glu Val Asn 
    2345                 2350                 2355             


Cys Ser  Phe Pro Leu Phe Met  Asn Gly Ile Ser Lys  Glu Leu Glu 
    2360                 2365                 2370             


Met Lys  Lys Val Tyr His Tyr  Gly Asp Tyr Val Xaa  Leu Lys Cys 
    2375                 2380                 2385             


Glu Asp  Gly Tyr Xaa Leu Glu  Gly Ser Pro Trp Ser  Gln Cys Gln 
    2390                 2395                 2400             


Ala Asp  Asp Arg Trp Asp Pro  Pro Leu Ala Lys Cys  Xaa Ser Arg 
    2405                 2410                 2415             


Xaa His  Asp Ala Leu Ile Val  Gly Xaa Leu Ser Gly  Xaa Ile Phe 
    2420                 2425                 2430             


Phe Ile  Leu Leu Ile Ile Phe  Leu Ser Trp Ile Ile  Leu Lys His 
    2435                 2440                 2445             


Arg Lys  Gly Asn Asn Ala His  Glu Asn Pro Lys Glu  Val Ala Ile 
    2450                 2455                 2460             


His Leu  His Ser Gln Gly Gly  Ser Ser Val His Pro  Arg Xaa Leu 
    2465                 2470                 2475             


Gln Xaa  Asn Glu Glu Asn Ser  Arg Val Leu Pro 
    2480                 2485                 


<210> 6825
<211> 661
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<400> 6825
Xaa Ser Leu Leu Ala Val Val Val Leu Leu Ala Leu Pro Val Ala Trp 
1               5                   10                  15      


Gly Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Xaa Asn 
            20                  25                  30          


Leu Xaa Asp Glu Phe Glu Phe Pro Ile Gly Xaa Tyr Leu Asn Tyr Glu 
        35                  40                  45              


Cys Arg Pro Gly Tyr Ser Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys 
    50                  55                  60                  


Asn Ser Val Trp Xaa Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys 
65                  70                  75                  80  


Arg Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Gly 
                85                  90                  95      


Ile Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Xaa Lys Gly Tyr Arg 
            100                 105                 110         


Leu Ile Gly Ser Ser Ser Ala Xaa Cys Ile Ile Ser Gly Asp Xaa Val 
        115                 120                 125             


Ile Trp Asp Asn Glu Xaa Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu 
    130                 135                 140                 


Pro Pro Xaa Ile Xaa Asn Gly Asp Phe Ile Ser Xaa Asn Arg Glu Asn 
145                 150                 155                 160 


Phe His Tyr Gly Ser Val Val Xaa Tyr Arg Cys Asn Pro Gly Ser Gly 
                165                 170                 175     


Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Xaa 
            180                 185                 190         


Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys 
        195                 200                 205             


Ile Ile Pro Asn Lys Cys Xaa Pro Pro Asn Val Glu Asn Gly Ile Leu 
    210                 215                 220                 


Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu Phe 
225                 230                 235                 240 


Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys Cys 
                245                 250                 255     


Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg Val 
            260                 265                 270         


Cys Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Xaa Gln Arg Asp 
        275                 280                 285             


Lys Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro 
    290                 295                 300                 


Gly Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys Xaa Pro Gln Gly 
305                 310                 315                 320 


Asp Trp Ser Pro Ala Ala Pro Xaa Cys Glu Val Lys Ser Cys Asp Asp 
                325                 330                 335     


Phe Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn Leu 
            340                 345                 350         


Gln Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln Leu 
        355                 360                 365             


Lys Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser Leu 
    370                 375                 380                 


Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Asn Pro 
385                 390                 395                 400 


Pro Ala Ile Leu Asn Gly Arg His Xaa Gly Xaa Pro Phe Gly Asp Ile 
                405                 410                 415     


Pro Tyr Gly Lys Glu Ile Ser Tyr Ala Cys Asp Xaa His Pro Asp Arg 
            420                 425                 430         


Gly Met Xaa Phe Asn Leu Ile Gly Glu Ser Ser Ile Arg Cys Xaa Ser 
        435                 440                 445             


Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys Glu 
    450                 455                 460                 


Leu Ser Val Pro Ala Ala Cys Pro His Pro Pro Lys Ile Gln Asn Gly 
465                 470                 475                 480 


His Tyr Ile Gly Gly His Val Ser Leu Tyr Leu Pro Gly Met Xaa Ile 
                485                 490                 495     


Ser Tyr Ile Cys Asp Pro Gly Tyr Leu Leu Val Gly Lys Gly Phe Ile 
            500                 505                 510         


Phe Cys Xaa Asp Gln Gly Ile Trp Ser Gln Leu Asp His Tyr Cys Lys 
        515                 520                 525             


Glu Val Asn Cys Ser Phe Pro Leu Phe Met Asn Gly Ile Ser Lys Glu 
    530                 535                 540                 


Leu Glu Met Lys Lys Val Tyr His Tyr Gly Asp Tyr Val Xaa Leu Lys 
545                 550                 555                 560 


Cys Glu Asp Gly Tyr Xaa Leu Glu Gly Ser Pro Trp Ser Gln Cys Gln 
                565                 570                 575     


Ala Asp Asp Arg Trp Asp Pro Pro Leu Ala Lys Cys Xaa Ser Arg Xaa 
            580                 585                 590         


His Asp Ala Leu Ile Val Gly Xaa Leu Ser Gly Xaa Ile Phe Phe Ile 
        595                 600                 605             


Leu Leu Ile Ile Phe Leu Ser Trp Ile Ile Leu Lys His Arg Lys Gly 
    610                 615                 620                 


Asn Asn Ala His Glu Asn Pro Lys Glu Val Ala Ile His Leu His Ser 
625                 630                 635                 640 


Gln Gly Gly Ser Ser Val His Pro Arg Xaa Leu Gln Xaa Asn Glu Glu 
                645                 650                 655     


Asn Ser Arg Tyr Leu 
            660     


<210> 6826
<211> 971
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<400> 6826
Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro 
1               5                   10                  15      


Gly Val Leu Gly Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly 
            20                  25                  30          


Arg Ile Ser Tyr Tyr Ser Xaa Pro Ile Ala Val Gly Xaa Val Ile Arg 
        35                  40                  45              


Tyr Ser Cys Ser Gly Xaa Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu 
    50                  55                  60                  


Cys Ile Xaa Lys Asp Lys Val Asp Gly Xaa Trp Asp Lys Pro Ala Pro 
65                  70                  75                  80  


Lys Cys Glu Tyr Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val 
                85                  90                  95      


Pro Gly Gly Tyr Lys Ile Arg Gly Ser Xaa Pro Tyr Arg His Gly Asp 
            100                 105                 110         


Ser Val Xaa Phe Ala Cys Lys Xaa Asn Phe Ser Met Asn Gly Asn Lys 
        115                 120                 125             


Ser Val Trp Cys Gln Ala Asn Asn Met Trp Gly Pro Xaa Arg Leu Pro 
    130                 135                 140                 


Xaa Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile 
145                 150                 155                 160 


His Asn Gly His His Xaa Ser Glu Asn Val Gly Ser Ile Ala Pro Gly 
                165                 170                 175     


Leu Ser Val Xaa Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu 
            180                 185                 190         


Lys Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro 
        195                 200                 205             


Xaa Cys Glu Glu Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly 
    210                 215                 220                 


Lys Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Xaa Ala Asn Phe 
225                 230                 235                 240 


Phe Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys 
                245                 250                 255     


Val Ile Ala Gly Gln Gly Val Ala Trp Xaa Lys Met Pro Val Cys Glu 
            260                 265                 270         


Glu Ile Phe Cys Pro Ser Pro Pro Pro Ile Leu Asn Gly Arg His Ile 
        275                 280                 285             


Gly Asn Ser Leu Ala Asn Val Ser Tyr Gly Ser Ile Val Xaa Tyr Xaa 
    290                 295                 300                 


Cys Asp Pro Asp Pro Glu Glu Gly Val Asn Phe Ile Leu Ile Gly Glu 
305                 310                 315                 320 


Ser Xaa Leu Arg Cys Xaa Val Asp Ser Gln Lys Xaa Gly Xaa Trp Ser 
                325                 330                 335     


Gly Pro Ala Pro Arg Cys Glu Leu Ser Xaa Ser Ala Val Gln Cys Pro 
            340                 345                 350         


His Pro Gln Ile Leu Arg Gly Arg Met Val Ser Gly Gln Lys Asp Arg 
        355                 360                 365             


Tyr Xaa Tyr Asn Asp Xaa Val Ile Phe Ala Cys Met Phe Gly Phe Xaa 
    370                 375                 380                 


Leu Lys Gly Ser Lys Gln Ile Arg Cys Asn Ala Gln Gly Xaa Trp Glu 
385                 390                 395                 400 


Pro Ser Ala Pro Val Cys Glu Lys Glu Cys Gln Ala Pro Pro Asn Ile 
                405                 410                 415     


Leu Asn Gly Gln Lys Glu Asp Arg His Met Val Arg Phe Asp Pro Gly 
            420                 425                 430         


Xaa Ser Ile Lys Tyr Ser Cys Asn Pro Gly Tyr Val Leu Val Gly Glu 
        435                 440                 445             


Glu Ser Ile Gln Cys Xaa Ser Glu Gly Val Trp Xaa Pro Pro Val Pro 
    450                 455                 460                 


Gln Cys Lys Val Ala Ala Cys Glu Ala Xaa Gly Arg Gln Leu Leu Xaa 
465                 470                 475                 480 


Lys Pro Gln His Gln Phe Val Arg Pro Asp Val Asn Ser Ser Cys Gly 
                485                 490                 495     


Glu Gly Tyr Lys Leu Ser Gly Ser Val Tyr Gln Glu Cys Gln Gly Xaa 
            500                 505                 510         


Ile Pro Trp Phe Met Glu Ile Arg Leu Cys Lys Glu Ile Xaa Cys Pro 
        515                 520                 525             


Pro Pro Pro Val Ile Tyr Asn Gly Ala His Xaa Gly Ser Ser Leu Glu 
    530                 535                 540                 


Asp Phe Pro Tyr Gly Xaa Xaa Val Xaa Tyr Xaa Cys Asn Pro Gly Pro 
545                 550                 555                 560 


Glu Arg Gly Val Glu Phe Ser Leu Ile Gly Glu Ser Xaa Ile Arg Cys 
                565                 570                 575     


Xaa Ser Asn Asp Gln Glu Arg Gly Xaa Trp Ser Gly Pro Ala Pro Leu 
            580                 585                 590         


Cys Lys Leu Ser Leu Leu Ala Val Gln Cys Ser His Val His Ile Ala 
        595                 600                 605             


Asn Gly Tyr Lys Ile Ser Gly Lys Glu Ala Pro Tyr Phe Tyr Asn Asp 
    610                 615                 620                 


Xaa Val Xaa Phe Lys Cys Tyr Ser Gly Phe Xaa Leu Lys Gly Ser Ser 
625                 630                 635                 640 


Gln Ile Arg Cys Lys Ala Asp Asn Xaa Trp Asp Pro Glu Ile Pro Val 
                645                 650                 655     


Cys Glu Lys Glu Xaa Cys Gln His Val Arg Gln Ser Leu Gln Glu Leu 
            660                 665                 670         


Pro Ala Gly Ser Arg Val Glu Leu Val Asn Xaa Ser Cys Gln Asp Gly 
        675                 680                 685             


Tyr Gln Leu Xaa Gly His Ala Tyr Gln Met Cys Gln Asp Ala Glu Asn 
    690                 695                 700                 


Gly Ile Trp Phe Lys Lys Ile Pro Leu Cys Lys Val Ile His Cys His 
705                 710                 715                 720 


Pro Pro Pro Val Ile Val Asn Gly Lys His Xaa Gly Met Met Ala Glu 
                725                 730                 735     


Asn Phe Leu Tyr Gly Asn Glu Val Ser Tyr Glu Cys Asp Gln Gly Phe 
            740                 745                 750         


Tyr Leu Leu Gly Glu Lys Lys Leu Gln Cys Arg Ser Asp Ser Lys Gly 
        755                 760                 765             


His Gly Ser Trp Ser Gly Pro Ser Pro Gln Cys Leu Arg Ser Pro Pro 
    770                 775                 780                 


Val Xaa Arg Cys Pro Asn Pro Glu Val Lys His Gly Tyr Lys Leu Asn 
785                 790                 795                 800 


Lys Xaa His Ser Ala Tyr Ser His Asn Asp Ile Val Tyr Val Asp Cys 
                805                 810                 815     


Asn Pro Gly Phe Ile Met Asn Gly Ser Arg Val Ile Arg Cys His Xaa 
            820                 825                 830         


Asp Asn Xaa Trp Val Pro Gly Val Pro Xaa Cys Ile Lys Lys Glu Val 
        835                 840                 845             


Asn Cys Ser Ser Pro Ala Asp Met Asp Gly Ile Gln Lys Gly Leu Glu 
    850                 855                 860                 


Pro Arg Lys Met Tyr Gln Tyr Gly Ala Val Val Xaa Leu Glu Cys Glu 
865                 870                 875                 880 


Asp Gly Tyr Met Leu Glu Gly Ser Pro Gln Ser Gln Cys Gln Ser Asp 
                885                 890                 895     


His Gln Trp Asn Pro Pro Leu Ala Val Cys Arg Ser Arg Ser Leu Ala 
            900                 905                 910         


Pro Val Leu Cys Gly Ile Ala Ala Gly Leu Ile Leu Leu Xaa Phe Leu 
        915                 920                 925             


Ile Val Ile Xaa Leu Tyr Val Ile Ser Lys His Arg Ala Arg Asn Tyr 
    930                 935                 940                 


Tyr Xaa Asp Xaa Ser Gln Lys Glu Ala Phe His Leu Glu Ala Arg Glu 
945                 950                 955                 960 


Val Tyr Ser Val Asp Pro Tyr Asn Pro Ala Ser 
                965                 970     


<210> 6827
<211> 1033
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (899)..(899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (988)..(988)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1010)..(1010)
<223> Selenocysteine

<400> 6827
Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro 
1               5                   10                  15      


Gly Val Leu Gly Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly 
            20                  25                  30          


Arg Ile Ser Tyr Tyr Ser Xaa Pro Ile Ala Val Gly Xaa Val Ile Arg 
        35                  40                  45              


Tyr Ser Cys Ser Gly Xaa Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu 
    50                  55                  60                  


Cys Ile Xaa Lys Asp Lys Val Asp Gly Xaa Trp Asp Lys Pro Ala Pro 
65                  70                  75                  80  


Lys Cys Glu Tyr Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val 
                85                  90                  95      


Pro Gly Gly Tyr Lys Ile Arg Gly Ser Xaa Pro Tyr Arg His Gly Asp 
            100                 105                 110         


Ser Val Xaa Phe Ala Cys Lys Xaa Asn Phe Ser Met Asn Gly Asn Lys 
        115                 120                 125             


Ser Val Trp Cys Gln Ala Asn Asn Met Trp Gly Pro Xaa Arg Leu Pro 
    130                 135                 140                 


Xaa Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile 
145                 150                 155                 160 


His Asn Gly His His Xaa Ser Glu Asn Val Gly Ser Ile Ala Pro Gly 
                165                 170                 175     


Leu Ser Val Xaa Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu 
            180                 185                 190         


Lys Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro 
        195                 200                 205             


Xaa Cys Glu Glu Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly 
    210                 215                 220                 


Lys Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Xaa Ala Asn Phe 
225                 230                 235                 240 


Phe Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys 
                245                 250                 255     


Val Ile Ala Gly Gln Gly Val Ala Trp Xaa Lys Met Pro Val Cys Glu 
            260                 265                 270         


Glu Ile Phe Cys Pro Ser Pro Pro Pro Ile Leu Asn Gly Arg His Ile 
        275                 280                 285             


Gly Asn Ser Leu Ala Asn Val Ser Tyr Gly Ser Ile Val Xaa Tyr Xaa 
    290                 295                 300                 


Cys Asp Pro Asp Pro Glu Glu Gly Val Asn Phe Ile Leu Ile Gly Glu 
305                 310                 315                 320 


Ser Xaa Leu Arg Cys Xaa Val Asp Ser Gln Lys Xaa Gly Xaa Trp Ser 
                325                 330                 335     


Gly Pro Ala Pro Arg Cys Glu Leu Ser Xaa Ser Ala Val Gln Cys Pro 
            340                 345                 350         


His Pro Gln Ile Leu Arg Gly Arg Met Val Ser Gly Gln Lys Asp Arg 
        355                 360                 365             


Tyr Xaa Tyr Asn Asp Xaa Val Ile Phe Ala Cys Met Phe Gly Phe Xaa 
    370                 375                 380                 


Leu Lys Gly Ser Lys Gln Ile Arg Cys Asn Ala Gln Gly Xaa Trp Glu 
385                 390                 395                 400 


Pro Ser Ala Pro Val Cys Glu Lys Glu Cys Gln Ala Pro Pro Asn Ile 
                405                 410                 415     


Leu Asn Gly Gln Lys Glu Asp Arg His Met Val Arg Phe Asp Pro Gly 
            420                 425                 430         


Xaa Ser Ile Lys Tyr Ser Cys Asn Pro Gly Tyr Val Leu Val Gly Glu 
        435                 440                 445             


Glu Ser Ile Gln Cys Xaa Ser Glu Gly Val Trp Xaa Pro Pro Val Pro 
    450                 455                 460                 


Gln Cys Lys Val Ala Ala Cys Glu Ala Xaa Gly Arg Gln Leu Leu Xaa 
465                 470                 475                 480 


Lys Pro Gln His Gln Phe Val Arg Pro Asp Val Asn Ser Ser Cys Gly 
                485                 490                 495     


Glu Gly Tyr Lys Leu Ser Gly Ser Val Tyr Gln Glu Cys Gln Gly Xaa 
            500                 505                 510         


Ile Pro Trp Phe Met Glu Ile Arg Leu Cys Lys Glu Ile Xaa Cys Pro 
        515                 520                 525             


Pro Pro Pro Val Ile Tyr Asn Gly Ala His Xaa Gly Ser Ser Leu Glu 
    530                 535                 540                 


Asp Phe Pro Tyr Gly Xaa Xaa Val Xaa Tyr Xaa Cys Asn Pro Gly Pro 
545                 550                 555                 560 


Glu Arg Gly Val Glu Phe Ser Leu Ile Gly Glu Ser Xaa Ile Arg Cys 
                565                 570                 575     


Xaa Ser Asn Asp Gln Glu Arg Gly Xaa Trp Ser Gly Pro Ala Pro Leu 
            580                 585                 590         


Cys Lys Leu Ser Leu Leu Ala Val Gln Cys Ser His Val His Ile Ala 
        595                 600                 605             


Asn Gly Tyr Lys Ile Ser Gly Lys Glu Ala Pro Tyr Phe Tyr Asn Asp 
    610                 615                 620                 


Xaa Val Xaa Phe Lys Cys Tyr Ser Gly Phe Xaa Leu Lys Gly Ser Ser 
625                 630                 635                 640 


Gln Ile Arg Cys Lys Ala Asp Asn Xaa Trp Asp Pro Glu Ile Pro Val 
                645                 650                 655     


Cys Glu Lys Glu Xaa Cys Gln His Val Arg Gln Ser Leu Gln Glu Leu 
            660                 665                 670         


Pro Ala Gly Ser Arg Val Glu Leu Val Asn Xaa Ser Cys Gln Asp Gly 
        675                 680                 685             


Tyr Gln Leu Xaa Gly His Ala Tyr Gln Met Cys Gln Asp Ala Glu Asn 
    690                 695                 700                 


Gly Ile Trp Phe Lys Lys Ile Pro Leu Cys Lys Val Ile His Cys His 
705                 710                 715                 720 


Pro Pro Pro Val Ile Val Asn Gly Lys His Xaa Gly Met Met Ala Glu 
                725                 730                 735     


Asn Phe Leu Tyr Gly Asn Glu Val Ser Tyr Glu Cys Asp Gln Gly Phe 
            740                 745                 750         


Tyr Leu Leu Gly Glu Lys Lys Leu Gln Cys Arg Ser Asp Ser Lys Gly 
        755                 760                 765             


His Gly Ser Trp Ser Gly Pro Ser Pro Gln Cys Leu Arg Ser Pro Pro 
    770                 775                 780                 


Val Xaa Arg Cys Pro Asn Pro Glu Val Lys His Gly Tyr Lys Leu Asn 
785                 790                 795                 800 


Lys Xaa His Ser Ala Tyr Ser His Asn Asp Ile Val Tyr Val Asp Cys 
                805                 810                 815     


Asn Pro Gly Phe Ile Met Asn Gly Ser Arg Val Ile Arg Cys His Xaa 
            820                 825                 830         


Asp Asn Xaa Trp Val Pro Gly Val Pro Xaa Cys Ile Lys Lys Ala Phe 
        835                 840                 845             


Ile Gly Cys Pro Pro Pro Pro Lys Xaa Pro Asn Gly Asn His Xaa Gly 
    850                 855                 860                 


Gly Asn Ile Ala Arg Phe Ser Pro Gly Met Ser Ile Leu Tyr Ser Cys 
865                 870                 875                 880 


Asp Gln Gly Tyr Leu Leu Val Gly Glu Ala Leu Leu Leu Cys Xaa His 
                885                 890                 895     


Glu Gly Xaa Trp Ser Gln Pro Ala Pro His Cys Lys Glu Val Asn Cys 
            900                 905                 910         


Ser Ser Pro Ala Asp Met Asp Gly Ile Gln Lys Gly Leu Glu Pro Arg 
        915                 920                 925             


Lys Met Tyr Gln Tyr Gly Ala Val Val Xaa Leu Glu Cys Glu Asp Gly 
    930                 935                 940                 


Tyr Met Leu Glu Gly Ser Pro Gln Ser Gln Cys Gln Ser Asp His Gln 
945                 950                 955                 960 


Trp Asn Pro Pro Leu Ala Val Cys Arg Ser Arg Ser Leu Ala Pro Val 
                965                 970                 975     


Leu Cys Gly Ile Ala Ala Gly Leu Ile Leu Leu Xaa Phe Leu Ile Val 
            980                 985                 990         


Ile Xaa Leu Tyr Val Ile Ser Lys  His Arg Ala Arg Asn  Tyr Tyr Xaa 
        995                 1000                 1005             


Asp Xaa  Ser Gln Lys Glu Ala  Phe His Leu Glu Ala  Arg Glu Val 
    1010                 1015                 1020             


Tyr Ser  Val Asp Pro Tyr Asn  Pro Ala Ser 
    1025                 1030             


<210> 6828
<211> 1092
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (922)..(922)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1069)
<223> Selenocysteine

<400> 6828
Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro 
1               5                   10                  15      


Gly Val Leu Gly Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly 
            20                  25                  30          


Arg Ile Ser Tyr Tyr Ser Xaa Pro Ile Ala Val Gly Xaa Val Ile Arg 
        35                  40                  45              


Tyr Ser Cys Ser Gly Xaa Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu 
    50                  55                  60                  


Cys Ile Xaa Lys Asp Lys Val Asp Gly Xaa Trp Asp Lys Pro Ala Pro 
65                  70                  75                  80  


Lys Cys Glu Tyr Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val 
                85                  90                  95      


Pro Gly Gly Tyr Lys Ile Arg Gly Ser Xaa Pro Tyr Arg His Gly Asp 
            100                 105                 110         


Ser Val Xaa Phe Ala Cys Lys Xaa Asn Phe Ser Met Asn Gly Asn Lys 
        115                 120                 125             


Ser Val Trp Cys Gln Ala Asn Asn Met Trp Gly Pro Xaa Arg Leu Pro 
    130                 135                 140                 


Xaa Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile 
145                 150                 155                 160 


His Asn Gly His His Xaa Ser Glu Asn Val Gly Ser Ile Ala Pro Gly 
                165                 170                 175     


Leu Ser Val Xaa Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu 
            180                 185                 190         


Lys Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro 
        195                 200                 205             


Xaa Cys Glu Glu Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly 
    210                 215                 220                 


Lys Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Xaa Ala Asn Phe 
225                 230                 235                 240 


Phe Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys 
                245                 250                 255     


Val Ile Ala Gly Gln Gly Val Ala Trp Xaa Lys Met Pro Val Cys Glu 
            260                 265                 270         


Glu Ile Phe Cys Pro Ser Pro Pro Pro Ile Leu Asn Gly Arg His Ile 
        275                 280                 285             


Gly Asn Ser Leu Ala Asn Val Ser Tyr Gly Ser Ile Val Xaa Tyr Xaa 
    290                 295                 300                 


Cys Asp Pro Asp Pro Glu Glu Gly Val Asn Phe Ile Leu Ile Gly Glu 
305                 310                 315                 320 


Ser Xaa Leu Arg Cys Xaa Val Asp Ser Gln Lys Xaa Gly Xaa Trp Ser 
                325                 330                 335     


Gly Pro Ala Pro Arg Cys Glu Leu Ser Xaa Ser Ala Val Gln Cys Pro 
            340                 345                 350         


His Pro Gln Ile Leu Arg Gly Arg Met Val Ser Gly Gln Lys Asp Arg 
        355                 360                 365             


Tyr Xaa Tyr Asn Asp Xaa Val Ile Phe Ala Cys Met Phe Gly Phe Xaa 
    370                 375                 380                 


Leu Lys Gly Ser Lys Gln Ile Arg Cys Asn Ala Gln Gly Xaa Trp Glu 
385                 390                 395                 400 


Pro Ser Ala Pro Val Cys Glu Lys Glu Cys Gln Ala Pro Pro Asn Ile 
                405                 410                 415     


Leu Asn Gly Gln Lys Glu Asp Arg His Met Val Arg Phe Asp Pro Gly 
            420                 425                 430         


Xaa Ser Ile Lys Tyr Ser Cys Asn Pro Gly Tyr Val Leu Val Gly Glu 
        435                 440                 445             


Glu Ser Ile Gln Cys Xaa Ser Glu Gly Val Trp Xaa Pro Pro Val Pro 
    450                 455                 460                 


Gln Cys Lys Val Ala Ala Cys Glu Ala Xaa Gly Arg Gln Leu Leu Xaa 
465                 470                 475                 480 


Lys Pro Gln His Gln Phe Val Arg Pro Asp Val Asn Ser Ser Cys Gly 
                485                 490                 495     


Glu Gly Tyr Lys Leu Ser Gly Ser Val Tyr Gln Glu Cys Gln Gly Xaa 
            500                 505                 510         


Ile Pro Trp Phe Met Glu Ile Arg Leu Cys Lys Glu Ile Xaa Cys Pro 
        515                 520                 525             


Pro Pro Pro Val Ile Tyr Asn Gly Ala His Xaa Gly Ser Ser Leu Glu 
    530                 535                 540                 


Asp Phe Pro Tyr Gly Xaa Xaa Val Xaa Tyr Xaa Cys Asn Pro Gly Pro 
545                 550                 555                 560 


Glu Arg Gly Val Glu Phe Ser Leu Ile Gly Glu Ser Xaa Ile Arg Cys 
                565                 570                 575     


Xaa Ser Asn Asp Gln Glu Arg Gly Xaa Trp Ser Gly Pro Ala Pro Leu 
            580                 585                 590         


Cys Lys Leu Ser Leu Leu Ala Val Gln Cys Ser His Val His Ile Ala 
        595                 600                 605             


Asn Gly Tyr Lys Ile Ser Gly Lys Glu Ala Pro Tyr Phe Tyr Asn Asp 
    610                 615                 620                 


Xaa Val Xaa Phe Lys Cys Tyr Ser Gly Phe Xaa Leu Lys Gly Ser Ser 
625                 630                 635                 640 


Gln Ile Arg Cys Lys Ala Asp Asn Xaa Trp Asp Pro Glu Ile Pro Val 
                645                 650                 655     


Cys Glu Lys Gly Cys Gln Ser Pro Pro Gly Leu His His Gly Arg His 
            660                 665                 670         


Xaa Gly Gly Asn Xaa Val Phe Phe Val Ser Gly Met Xaa Val Asp Tyr 
        675                 680                 685             


Xaa Cys Asp Pro Gly Tyr Leu Leu Val Gly Asn Lys Ser Ile His Cys 
    690                 695                 700                 


Met Pro Ser Gly Asn Trp Ser Pro Ser Ala Pro Arg Cys Glu Glu Xaa 
705                 710                 715                 720 


Cys Gln His Val Arg Gln Ser Leu Gln Glu Leu Pro Ala Gly Ser Arg 
                725                 730                 735     


Val Glu Leu Val Asn Xaa Ser Cys Gln Asp Gly Tyr Gln Leu Xaa Gly 
            740                 745                 750         


His Ala Tyr Gln Met Cys Gln Asp Ala Glu Asn Gly Ile Trp Phe Lys 
        755                 760                 765             


Lys Ile Pro Leu Cys Lys Val Ile His Cys His Pro Pro Pro Val Ile 
    770                 775                 780                 


Val Asn Gly Lys His Xaa Gly Met Met Ala Glu Asn Phe Leu Tyr Gly 
785                 790                 795                 800 


Asn Glu Val Ser Tyr Glu Cys Asp Gln Gly Phe Tyr Leu Leu Gly Glu 
                805                 810                 815     


Lys Lys Leu Gln Cys Arg Ser Asp Ser Lys Gly His Gly Ser Trp Ser 
            820                 825                 830         


Gly Pro Ser Pro Gln Cys Leu Arg Ser Pro Pro Val Xaa Arg Cys Pro 
        835                 840                 845             


Asn Pro Glu Val Lys His Gly Tyr Lys Leu Asn Lys Xaa His Ser Ala 
    850                 855                 860                 


Tyr Ser His Asn Asp Ile Val Tyr Val Asp Cys Asn Pro Gly Phe Ile 
865                 870                 875                 880 


Met Asn Gly Ser Arg Val Ile Arg Cys His Xaa Asp Asn Xaa Trp Val 
                885                 890                 895     


Pro Gly Val Pro Xaa Cys Ile Lys Lys Ala Phe Ile Gly Cys Pro Pro 
            900                 905                 910         


Pro Pro Lys Xaa Pro Asn Gly Asn His Xaa Gly Gly Asn Ile Ala Arg 
        915                 920                 925             


Phe Ser Pro Gly Met Ser Ile Leu Tyr Ser Cys Asp Gln Gly Tyr Leu 
    930                 935                 940                 


Leu Val Gly Glu Ala Leu Leu Leu Cys Xaa His Glu Gly Xaa Trp Ser 
945                 950                 955                 960 


Gln Pro Ala Pro His Cys Lys Glu Val Asn Cys Ser Ser Pro Ala Asp 
                965                 970                 975     


Met Asp Gly Ile Gln Lys Gly Leu Glu Pro Arg Lys Met Tyr Gln Tyr 
            980                 985                 990         


Gly Ala Val Val Xaa Leu Glu Cys  Glu Asp Gly Tyr Met  Leu Glu Gly 
        995                 1000                 1005             


Ser Pro  Gln Ser Gln Cys Gln  Ser Asp His Gln Trp  Asn Pro Pro 
    1010                 1015                 1020             


Leu Ala  Val Cys Arg Ser Arg  Ser Leu Ala Pro Val  Leu Cys Gly 
    1025                 1030                 1035             


Ile Ala  Ala Gly Leu Ile Leu  Leu Xaa Phe Leu Ile  Val Ile Xaa 
    1040                 1045                 1050             


Leu Tyr  Val Ile Ser Lys His  Arg Ala Arg Asn Tyr  Tyr Xaa Asp 
    1055                 1060                 1065             


Xaa Ser  Gln Lys Glu Ala Phe  His Leu Glu Ala Arg  Glu Val Tyr 
    1070                 1075                 1080             


Ser Val  Asp Pro Tyr Asn Pro  Ala Ser 
    1085                 1090         


<210> 6829
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<400> 6829
Met Pro Asn Phe Ala Gly Xaa Trp Lys Met Arg Ser Ser Glu Asn Phe 
1               5                   10                  15      


Asp Glu Leu Leu Lys Ala Leu Gly Val Asn Ala Met Leu Arg Lys Val 
            20                  25                  30          


Ala Val Ala Ala Ala Ser Lys Pro His Val Glu Ile Arg Gln Asp Gly 
        35                  40                  45              


Asp Gln Phe Tyr Ile Lys Xaa Ser Xaa Xaa Val Arg Xaa Xaa Glu Ile 
    50                  55                  60                  


Asn Phe Lys Val Gly Glu Gly Phe Glu Glu Glu Xaa Val Asp Gly Arg 
65                  70                  75                  80  


Lys Cys Arg Ser Leu Ala Xaa Trp Glu Asn Glu Asn Lys Ile His Cys 
                85                  90                  95      


Xaa Gln Xaa Leu Leu Glu Gly Asp Gly Pro Lys Xaa Tyr Trp Xaa Arg 
            100                 105                 110         


Glu Leu Ala Asn Asp Glu Leu Ile Leu Xaa Phe Gly Ala Asp Asp Val 
        115                 120                 125             


Val Cys Xaa Arg Ile Tyr Val Arg Glu 
    130                 135         


<210> 6830
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<400> 6830
Xaa Asp Glu Leu Leu Lys Ala Leu Gly Val Asn Ala Met Leu Arg Lys 
1               5                   10                  15      


Val Ala Val Ala Ala Ala Ser Lys Pro His Val Glu Ile Arg Gln Asp 
            20                  25                  30          


Gly Asp Gln Phe Tyr Ile Lys Xaa Ser Xaa Xaa Val Arg Xaa Xaa Glu 
        35                  40                  45              


Ile Asn Phe Lys Val Gly Glu Gly Phe Glu Glu Glu Xaa Val Asp Gly 
    50                  55                  60                  


Arg Lys Cys Arg Val Arg Pro Gln Ser His Tyr Ser Val Pro Val Ser 
65                  70                  75                  80  


Pro Leu Gly Ala His Gly Pro Leu Leu Leu Glu Glu Pro Val Ser Pro 
                85                  90                  95      


Phe Ala Ala Cys Gly Ala Pro Ser Leu Gln Glu Phe Ser His Leu Gly 
            100                 105                 110         


Glu 
    


<210> 6831
<211> 82
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<400> 6831
Met Pro Asn Phe Ser Gly Asn Trp Lys Ile Ile Arg Ser Glu Asn Phe 
1               5                   10                  15      


Glu Glu Leu Leu Lys Val Leu Gly Val Asn Val Met Leu Arg Lys Ile 
            20                  25                  30          


Ala Val Ala Ala Ala Ser Lys Pro Ala Val Glu Ile Lys Gln Glu Gly 
        35                  40                  45              


Asp Xaa Phe Tyr Ile Lys Xaa Ser Xaa Xaa Val Arg Xaa Xaa Glu Ile 
    50                  55                  60                  


Asn Phe Lys Val Gly Glu Glu Phe Glu Glu Gln Xaa Val Asp Gly Arg 
65                  70                  75                  80  


Pro Cys 
        


<210> 6832
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<400> 6832
Met Pro Asn Phe Ser Gly Asn Trp Lys Ile Ile Arg Ser Glu Asn Phe 
1               5                   10                  15      


Glu Glu Leu Leu Lys Val Leu Gly Val Asn Val Met Leu Arg Lys Ile 
            20                  25                  30          


Ala Val Ala Ala Ala Ser Lys Pro Ala Val Glu Ile Lys Gln Glu Gly 
        35                  40                  45              


Asp Xaa Phe Tyr Ile Lys Xaa Ser Xaa Xaa Val Arg Xaa Xaa Glu Ile 
    50                  55                  60                  


Asn Phe Lys Val Gly Glu Glu Phe Glu Glu Gln Xaa Val Asp Gly Arg 
65                  70                  75                  80  


Pro Cys Lys Ser Leu Val Lys Trp Glu Ser Glu Asn Lys Met Val Cys 
                85                  90                  95      


Glu Gln Lys Leu Leu Lys Gly Glu Gly Pro Lys Xaa Ser Trp Xaa Arg 
            100                 105                 110         


Glu Leu Xaa Asn Asp Gly Glu Leu Ile Leu Xaa Met Xaa Ala Asp Asp 
        115                 120                 125             


Val Val Cys Xaa Arg Val Tyr Val Arg Glu 
    130                 135             


<210> 6833
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<400> 6833
Met Glu Ala Arg Asp Lys Gln Val Leu Arg Ser Leu Arg Leu Glu Leu 
1               5                   10                  15      


Gly Ala Glu Val Leu Val Glu Gly Leu Val Leu Gln Tyr Leu Tyr Gln 
            20                  25                  30          


Glu Gly Ile Leu Xaa Glu Asn His Ile Gln Glu Ile Asn Ala Gln Xaa 
        35                  40                  45              


Xaa Gly Leu Arg Lys Xaa Met Leu Leu Leu Asp Ile Leu Pro Ser Arg 
    50                  55                  60                  


Gly Pro Lys Ala Phe Asp Xaa Phe Leu Asp Ser Leu Gln Glu Phe Pro 
65                  70                  75                  80  


Trp Val Arg Glu Lys Leu Lys Lys Ala Arg Glu Glu Ala Met Xaa Asp 
                85                  90                  95      


Leu Pro Ala Glu Met Arg Lys Leu Arg Pro Lys Asp Ser Val Xaa Cys 
            100                 105                 110         


Leu Ala Ser Gln Leu Xaa Trp Arg Phe 
        115                 120     


<210> 6834
<211> 103
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 6834
Met Glu Ala Arg Asp Lys Gln Val Leu Arg Ser Leu Arg Leu Glu Leu 
1               5                   10                  15      


Gly Ala Glu Val Leu Val Glu Gly Leu Val Leu Gln Tyr Leu Tyr Gln 
            20                  25                  30          


Glu Gly Ile Leu Xaa Glu Asn His Ile Gln Glu Ile Asn Ala Gln Xaa 
        35                  40                  45              


Xaa Gly Leu Arg Lys Xaa Met Leu Leu Leu Asp Ile Leu Pro Ser Arg 
    50                  55                  60                  


Gly Pro Lys Ala Phe Asp Xaa Phe Leu Asp Ser Leu Gln Glu Phe Pro 
65                  70                  75                  80  


Trp Val Arg Glu Lys Leu Lys Lys Ala Arg Glu Glu Ala Met Xaa Asp 
                85                  90                  95      


Leu Pro Ala Gly Cys Trp Pro 
            100             


<210> 6835
<211> 199
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<400> 6835
Met Glu Ala Arg Asp Lys Gln Val Leu Arg Ser Leu Arg Leu Glu Leu 
1               5                   10                  15      


Gly Ala Glu Val Leu Val Glu Gly Leu Val Leu Gln Tyr Leu Tyr Gln 
            20                  25                  30          


Glu Gly Ile Leu Xaa Glu Asn His Ile Gln Glu Ile Asn Ala Gln Xaa 
        35                  40                  45              


Xaa Gly Leu Arg Lys Xaa Met Leu Leu Leu Asp Ile Leu Pro Ser Arg 
    50                  55                  60                  


Gly Pro Lys Ala Phe Asp Xaa Phe Leu Asp Ser Leu Gln Glu Phe Pro 
65                  70                  75                  80  


Trp Val Arg Glu Lys Leu Lys Lys Ala Arg Glu Glu Ala Met Xaa Asp 
                85                  90                  95      


Leu Pro Ala Gly Asp Arg Leu Xaa Gly Ile Pro Ser His Ile Leu Asn 
            100                 105                 110         


Ser Ser Pro Ser Asp Arg Gln Ile Asn Gln Leu Ala Gln Arg Leu Gly 
        115                 120                 125             


Pro Glu Trp Glu Pro Met Val Leu Ser Leu Gly Leu Ser Gln Xaa Asp 
    130                 135                 140                 


Ile Tyr Arg Cys Lys Ala Asn His Pro His Asn Val Gln Ser Gln Val 
145                 150                 155                 160 


Val Glu Ala Phe Ile Arg Trp Arg Gln Arg Phe Gly Lys Gln Ala Xaa 
                165                 170                 175     


Phe Gln Ser Leu His Asn Gly Leu Arg Ala Val Glu Val Asp Pro Ser 
            180                 185                 190         


Leu Leu Leu His Met Leu Glu 
        195                 


<210> 6836
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 6836
Met Glu Ala Arg Asp Lys Gln Val Leu Arg Ser Leu Arg Leu Glu Leu 
1               5                   10                  15      


Gly Ala Glu Val Leu Val Glu Gly Leu Val Leu Gln Tyr Leu Tyr Gln 
            20                  25                  30          


Glu Gly Ile Leu Xaa Glu Asn His Ile Gln Glu Ile Asn Ala Gln Xaa 
        35                  40                  45              


Xaa Gly Leu Arg Lys Xaa Met Leu Leu Leu Asp Ile Leu Pro Ser Arg 
    50                  55                  60                  


Gly Pro Lys Ala Phe Asp Xaa Phe Leu Asp Ser Leu Gln Glu Phe Pro 
65                  70                  75                  80  


Trp Val Arg Glu Lys Leu Lys Lys Ala Arg Glu Glu Ala Met Xaa Asp 
                85                  90                  95      


Leu Pro Ala Gly Leu Glu Glu Lys Gly Arg Xaa Gly Arg Arg Met Gly 
            100                 105                 110         


Trp Gly Ala Gly Glu Glu Lys Gly Gln Lys Cys Gln Xaa Val Gly Met 
        115                 120                 125             


Arg Xaa 
    130 


<210> 6837
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<400> 6837
Met Glu Ala Arg Asp Lys Gln Val Leu Arg Ser Leu Arg Leu Glu Leu 
1               5                   10                  15      


Gly Ala Glu Val Leu Val Glu Gly Leu Val Leu Gln Tyr Leu Tyr Gln 
            20                  25                  30          


Glu Gly Ile Leu Xaa Glu Asn His Ile Gln Glu Ile Asn Ala Gln Xaa 
        35                  40                  45              


Xaa Gly Leu Arg Lys Xaa Met Leu Leu Leu Asp Ile Leu Pro Ser Arg 
    50                  55                  60                  


Gly Pro Lys Ala Phe Asp Xaa Phe Leu Asp Ser Leu Gln Glu Phe Pro 
65                  70                  75                  80  


Trp Val Arg Glu Lys Leu Lys Lys Ala Arg Glu Glu Ala Met Xaa Asp 
                85                  90                  95      


Leu Pro Ala Val Ala Ile Ile Arg Leu Pro Arg Glu Leu Ser Leu Pro 
            100                 105                 110         


Xaa Leu Leu 
        115 


<210> 6838
<211> 42
<212> PRT
<213> Homo sapiens

<400> 6838
Glu Lys Asp Ile Asp Glu Cys Ala Ser Asp Pro Cys Val Asn Gly Gly 
1               5                   10                  15      


Leu Cys Gln Asp Leu Leu Asn Lys Phe Gln Cys Leu Cys Asp Val Ala 
            20                  25                  30          


Phe Ala Gly Glu Arg Cys Glu Val Asp Tyr 
        35                  40          


<210> 6839
<211> 870
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<400> 6839
Met Ala Leu Lys Asn Ile Asn Tyr Leu Leu Ile Phe Tyr Leu Ser Phe 
1               5                   10                  15      


Ser Leu Leu Ile Tyr Ile Lys Asn Ser Phe Cys Asn Lys Asn Asn Xaa 
            20                  25                  30          


Arg Cys Leu Ser Asn Ser Cys Gln Asn Asn Ser Xaa Cys Lys Asp Phe 
        35                  40                  45              


Ser Lys Asp Asn Asp Cys Ser Cys Ser Asp Xaa Ala Asn Asn Leu Asp 
    50                  55                  60                  


Lys Asp Cys Asp Asn Met Lys Asp Pro Cys Phe Ser Asn Pro Cys Gln 
65                  70                  75                  80  


Gly Ser Ala Xaa Cys Val Asn Xaa Pro Gly Glu Arg Ser Phe Leu Cys 
                85                  90                  95      


Lys Cys Pro Pro Gly Tyr Ser Gly Xaa Ile Cys Glu Xaa Xaa Ile Gly 
            100                 105                 110         


Ser Cys Gly Lys Asn Ser Cys Gln His Gly Gly Ile Cys His Gln Asp 
        115                 120                 125             


Pro Ile Tyr Pro Val Cys Ile Cys Pro Ala Gly Tyr Ala Gly Arg Phe 
    130                 135                 140                 


Cys Glu Ile Asp His Asp Glu Cys Ala Ser Ser Pro Cys Gln Asn Gly 
145                 150                 155                 160 


Ala Val Cys Gln Asp Gly Ile Asp Gly Tyr Ser Cys Phe Cys Val Pro 
                165                 170                 175     


Gly Tyr Gln Gly Arg His Cys Asp Leu Glu Val Asp Glu Cys Ala Ser 
            180                 185                 190         


Asp Pro Cys Lys Asn Glu Ala Xaa Cys Leu Asn Glu Ile Gly Arg Tyr 
        195                 200                 205             


Xaa Cys Ile Cys Pro His Asn Tyr Ser Gly Val Asn Cys Glu Leu Glu 
    210                 215                 220                 


Ile Asp Glu Cys Trp Ser Gln Pro Cys Leu Asn Gly Ala Xaa Cys Gln 
225                 230                 235                 240 


Asp Ala Leu Gly Ala Tyr Phe Cys Asp Cys Ala Pro Gly Phe Leu Gly 
                245                 250                 255     


Asp His Cys Glu Leu Asn Xaa Asp Glu Cys Ala Ser Gln Pro Cys Leu 
            260                 265                 270         


His Gly Gly Leu Cys Val Asp Gly Glu Asn Arg Tyr Ser Cys Asn Cys 
        275                 280                 285             


Xaa Gly Ser Gly Phe Xaa Gly Xaa His Cys Glu Xaa Leu Met Pro Leu 
    290                 295                 300                 


Cys Trp Ser Lys Pro Cys His Asn Asn Ala Xaa Cys Glu Asp Ser Val 
305                 310                 315                 320 


Asp Asn Tyr Xaa Cys His Cys Trp Pro Gly Tyr Xaa Gly Ala Gln Cys 
                325                 330                 335     


Glu Ile Asp Leu Asn Glu Cys Asn Ser Asn Pro Cys Gln Ser Asn Gly 
            340                 345                 350         


Glu Cys Val Glu Leu Ser Ser Glu Lys Gln Tyr Gly Arg Ile Xaa Gly 
        355                 360                 365             


Leu Pro Ser Ser Phe Ser Tyr His Glu Ala Ser Gly Tyr Val Cys Ile 
    370                 375                 380                 


Cys Gln Pro Gly Phe Xaa Gly Ile His Cys Glu Glu Asp Val Asn Glu 
385                 390                 395                 400 


Cys Ser Ser Asn Pro Cys Gln Asn Gly Gly Xaa Cys Glu Asn Leu Pro 
                405                 410                 415     


Gly Asn Tyr Xaa Cys His Cys Pro Phe Asp Asn Leu Ser Arg Xaa Phe 
            420                 425                 430         


Tyr Gly Gly Arg Asp Cys Ser Asp Ile Leu Leu Gly Cys Xaa His Gln 
        435                 440                 445             


Gln Cys Leu Asn Asn Gly Xaa Cys Ile Pro His Phe Gln Asp Gly Gln 
    450                 455                 460                 


His Gly Phe Ser Cys Leu Cys Pro Ser Gly Tyr Xaa Gly Ser Leu Cys 
465                 470                 475                 480 


Glu Ile Ala Xaa Xaa Leu Ser Phe Glu Gly Asp Gly Phe Leu Trp Val 
                485                 490                 495     


Lys Ser Gly Ser Val Xaa Xaa Lys Gly Ser Val Cys Asn Ile Ala Leu 
            500                 505                 510         


Arg Phe Gln Xaa Val Gln Pro Met Ala Leu Leu Leu Phe Arg Ser Asn 
        515                 520                 525             


Arg Asp Val Phe Val Lys Leu Glu Leu Leu Ser Gly Tyr Ile His Leu 
    530                 535                 540                 


Ser Ile Gln Val Asn Asn Gln Ser Lys Val Leu Leu Phe Ile Ser His 
545                 550                 555                 560 


Asn Xaa Ser Asp Gly Glu Trp His Phe Val Glu Val Ile Phe Ala Glu 
                565                 570                 575     


Ala Val Xaa Leu Xaa Leu Ile Asp Asp Ser Cys Lys Glu Lys Cys Ile 
            580                 585                 590         


Ala Lys Ala Pro Xaa Pro Leu Glu Ser Asp Gln Ser Ile Cys Ala Phe 
        595                 600                 605             


Gln Asn Ser Phe Leu Gly Gly Leu Pro Val Gly Met Xaa Ser Asn Gly 
    610                 615                 620                 


Val Ala Leu Leu Asn Phe Tyr Asn Met Pro Ser Xaa Pro Ser Phe Val 
625                 630                 635                 640 


Gly Cys Leu Gln Asp Ile Lys Ile Asp Trp Asn His Ile Xaa Leu Glu 
                645                 650                 655     


Asn Ile Ser Ser Gly Ser Ser Leu Asn Val Lys Ala Gly Cys Val Arg 
            660                 665                 670         


Lys Asp Trp Cys Glu Ser Gln Pro Cys Gln Ser Arg Gly Arg Cys Ile 
        675                 680                 685             


Asn Leu Trp Leu Ser Tyr Gln Cys Asp Cys His Arg Pro Tyr Glu Gly 
    690                 695                 700                 


Pro Asn Cys Leu Arg Gly Lys Phe Cys Arg Gln Ser Arg Leu Pro Ser 
705                 710                 715                 720 


Xaa Val Cys Gly Asn Glu Lys Xaa Asn Leu Xaa Cys Tyr Asn Gly Gly 
                725                 730                 735     


Asn Cys Xaa Glu Phe Gln Xaa Glu Leu Lys Cys Met Cys Arg Pro Gly 
            740                 745                 750         


Phe Xaa Gly Glu Trp Cys Glu Lys Asp Ile Asp Glu Cys Ala Ser Asp 
        755                 760                 765             


Pro Cys Val Asn Gly Gly Leu Cys Gln Asp Leu Leu Asn Lys Phe Gln 
    770                 775                 780                 


Cys Leu Cys Asp Val Ala Phe Ala Gly Glu Arg Cys Glu Val Asp Leu 
785                 790                 795                 800 


Ala Asp Asp Leu Ile Ser Asp Ile Phe Xaa Xaa Ile Gly Ser Val Xaa 
                805                 810                 815     


Val Ala Leu Leu Leu Ile Leu Leu Leu Ala Ile Val Ala Ser Val Val 
            820                 825                 830         


Xaa Ser Asn Lys Arg Ala Xaa Gln Gly Xaa Tyr Ser Pro Ser Arg Gln 
        835                 840                 845             


Glu Lys Glu Gly Ser Arg Val Glu Met Trp Asn Leu Met Pro Pro Pro 
    850                 855                 860                 


Ala Met Glu Arg Leu Ile 
865                 870 


<210> 6840
<211> 1376
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1245)..(1245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1267)..(1267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<400> 6840
Met Ala Leu Lys Asn Ile Asn Tyr Leu Leu Ile Phe Tyr Leu Ser Phe 
1               5                   10                  15      


Ser Leu Leu Ile Tyr Ile Lys Asn Ser Phe Cys Asn Lys Asn Asn Xaa 
            20                  25                  30          


Arg Cys Leu Ser Asn Ser Cys Gln Asn Asn Ser Xaa Cys Lys Asp Phe 
        35                  40                  45              


Ser Lys Asp Asn Asp Cys Ser Cys Ser Asp Xaa Ala Asn Asn Leu Asp 
    50                  55                  60                  


Lys Asp Cys Asp Asn Met Lys Asp Pro Cys Phe Ser Asn Pro Cys Gln 
65                  70                  75                  80  


Gly Ser Ala Xaa Cys Val Asn Xaa Pro Gly Glu Arg Ser Phe Leu Cys 
                85                  90                  95      


Lys Cys Pro Pro Gly Tyr Ser Gly Xaa Ile Cys Glu Xaa Xaa Ile Gly 
            100                 105                 110         


Ser Cys Gly Lys Asn Ser Cys Gln His Gly Gly Ile Cys His Gln Asp 
        115                 120                 125             


Pro Ile Tyr Pro Val Cys Ile Cys Pro Ala Gly Tyr Ala Gly Arg Phe 
    130                 135                 140                 


Cys Glu Ile Asp His Asp Glu Cys Ala Ser Ser Pro Cys Gln Asn Gly 
145                 150                 155                 160 


Ala Val Cys Gln Asp Gly Ile Asp Gly Tyr Ser Cys Phe Cys Val Pro 
                165                 170                 175     


Gly Tyr Gln Gly Arg His Cys Asp Leu Glu Val Asp Glu Cys Ala Ser 
            180                 185                 190         


Asp Pro Cys Lys Asn Glu Ala Xaa Cys Leu Asn Glu Ile Gly Arg Tyr 
        195                 200                 205             


Xaa Cys Ile Cys Pro His Asn Tyr Ser Gly Val Asn Cys Glu Leu Glu 
    210                 215                 220                 


Ile Asp Glu Cys Trp Ser Gln Pro Cys Leu Asn Gly Ala Xaa Cys Gln 
225                 230                 235                 240 


Asp Ala Leu Gly Ala Tyr Phe Cys Asp Cys Ala Pro Gly Phe Leu Gly 
                245                 250                 255     


Asp His Cys Glu Leu Asn Xaa Asp Glu Cys Ala Ser Gln Pro Cys Leu 
            260                 265                 270         


His Gly Gly Leu Cys Val Asp Gly Glu Asn Arg Tyr Ser Cys Asn Cys 
        275                 280                 285             


Xaa Gly Ser Gly Phe Xaa Gly Xaa His Cys Glu Xaa Leu Met Pro Leu 
    290                 295                 300                 


Cys Trp Ser Lys Pro Cys His Asn Asn Ala Xaa Cys Glu Asp Ser Val 
305                 310                 315                 320 


Asp Asn Tyr Xaa Cys His Cys Trp Pro Gly Tyr Xaa Gly Ala Gln Cys 
                325                 330                 335     


Glu Ile Asp Leu Asn Glu Cys Asn Ser Asn Pro Cys Gln Ser Asn Gly 
            340                 345                 350         


Glu Cys Val Glu Leu Ser Ser Glu Lys Gln Tyr Gly Arg Ile Xaa Gly 
        355                 360                 365             


Leu Pro Ser Ser Phe Ser Tyr His Glu Ala Ser Gly Tyr Val Cys Ile 
    370                 375                 380                 


Cys Gln Pro Gly Phe Xaa Gly Ile His Cys Glu Glu Asp Val Asn Glu 
385                 390                 395                 400 


Cys Ser Ser Asn Pro Cys Gln Asn Gly Gly Xaa Cys Glu Asn Leu Pro 
                405                 410                 415     


Gly Asn Tyr Xaa Cys His Cys Pro Phe Asp Asn Leu Ser Arg Xaa Phe 
            420                 425                 430         


Tyr Gly Gly Arg Asp Cys Ser Asp Ile Leu Leu Gly Cys Xaa His Gln 
        435                 440                 445             


Gln Cys Leu Asn Asn Gly Xaa Cys Ile Pro His Phe Gln Asp Gly Gln 
    450                 455                 460                 


His Gly Phe Ser Cys Leu Cys Pro Ser Gly Tyr Xaa Gly Ser Leu Cys 
465                 470                 475                 480 


Glu Ile Ala Xaa Xaa Leu Ser Phe Glu Gly Asp Gly Phe Leu Trp Val 
                485                 490                 495     


Lys Ser Gly Ser Val Xaa Xaa Lys Gly Ser Val Cys Asn Ile Ala Leu 
            500                 505                 510         


Arg Phe Gln Xaa Val Gln Pro Met Ala Leu Leu Leu Phe Arg Ser Asn 
        515                 520                 525             


Arg Asp Val Phe Val Lys Leu Glu Leu Leu Ser Gly Tyr Ile His Leu 
    530                 535                 540                 


Ser Ile Gln Val Asn Asn Gln Ser Lys Val Leu Leu Phe Ile Ser His 
545                 550                 555                 560 


Asn Xaa Ser Asp Gly Glu Trp His Phe Val Glu Val Ile Phe Ala Glu 
                565                 570                 575     


Ala Val Xaa Leu Xaa Leu Ile Asp Asp Ser Cys Lys Glu Lys Cys Ile 
            580                 585                 590         


Ala Lys Ala Pro Xaa Pro Leu Glu Ser Asp Gln Ser Ile Cys Ala Phe 
        595                 600                 605             


Gln Asn Ser Phe Leu Gly Gly Leu Pro Val Gly Met Xaa Ser Asn Gly 
    610                 615                 620                 


Val Ala Leu Leu Asn Phe Tyr Asn Met Pro Ser Xaa Pro Ser Phe Val 
625                 630                 635                 640 


Gly Cys Leu Gln Asp Ile Lys Ile Asp Trp Asn His Ile Xaa Leu Glu 
                645                 650                 655     


Asn Ile Ser Ser Gly Ser Ser Leu Asn Val Lys Ala Gly Cys Val Arg 
            660                 665                 670         


Lys Asp Trp Cys Glu Ser Gln Pro Cys Gln Ser Arg Gly Arg Cys Ile 
        675                 680                 685             


Asn Leu Trp Leu Ser Tyr Gln Cys Asp Cys His Arg Pro Tyr Glu Gly 
    690                 695                 700                 


Pro Asn Cys Leu Arg Glu Tyr Val Ala Gly Arg Phe Gly Gln Asp Asp 
705                 710                 715                 720 


Ser Xaa Gly Tyr Val Ile Phe Xaa Leu Asp Glu Ser Tyr Gly Asp Xaa 
                725                 730                 735     


Ile Ser Leu Ser Met Phe Val Arg Xaa Leu Gln Pro Ser Gly Leu Leu 
            740                 745                 750         


Leu Ala Leu Glu Asn Ser Xaa Tyr Gln Tyr Ile Arg Val Trp Leu Glu 
        755                 760                 765             


Arg Gly Arg Leu Ala Met Leu Xaa Pro Asn Ser Pro Lys Leu Val Val 
    770                 775                 780                 


Lys Phe Val Leu Asn Asp Gly Asn Val His Leu Ile Ser Leu Lys Ile 
785                 790                 795                 800 


Lys Pro Tyr Lys Ile Glu Leu Tyr Gln Ser Ser Gln Asn Leu Gly Phe 
                805                 810                 815     


Ile Ser Ala Ser Xaa Trp Lys Ile Glu Lys Gly Asp Val Ile Tyr Ile 
            820                 825                 830         


Gly Gly Leu Pro Asp Lys Gln Glu Xaa Glu Leu Asn Gly Gly Phe Phe 
        835                 840                 845             


Lys Gly Cys Ile Gln Asp Val Arg Leu Asn Asn Gln Asn Leu Glu Phe 
    850                 855                 860                 


Phe Pro Asn Pro Xaa Asn Asn Ala Ser Leu Asn Pro Val Leu Val Asn 
865                 870                 875                 880 


Val Xaa Gln Gly Cys Ala Gly Asp Asn Ser Cys Lys Ser Asn Pro Cys 
                885                 890                 895     


His Asn Gly Gly Val Cys His Ser Arg Trp Asp Asp Phe Ser Cys Ser 
            900                 905                 910         


Cys Pro Ala Leu Xaa Ser Gly Lys Ala Cys Glu Glu Val Gln Trp Cys 
        915                 920                 925             


Gly Phe Ser Pro Cys Pro His Gly Ala Gln Cys Gln Pro Val Leu Gln 
    930                 935                 940                 


Gly Phe Glu Cys Ile Ala Asn Ala Val Phe Asn Gly Gln Ser Gly Gln 
945                 950                 955                 960 


Ile Leu Phe Arg Ser Asn Gly Asn Ile Xaa Arg Glu Leu Xaa Asn Ile 
                965                 970                 975     


Xaa Phe Gly Phe Arg Xaa Arg Asp Ala Asn Val Ile Ile Leu His Ala 
            980                 985                 990         


Glu Lys Glu Pro Glu Phe Leu Asn  Ile Ser Ile Gln Asp  Ser Arg Leu 
        995                 1000                 1005             


Phe Phe  Gln Leu Gln Ser Gly  Asn Ser Phe Tyr Met  Leu Ser Leu 
    1010                 1015                 1020             


Xaa Ser  Leu Gln Ser Val Asn  Asp Gly Xaa Trp His  Glu Val Xaa 
    1025                 1030                 1035             


Leu Ser  Met Xaa Asp Pro Leu  Ser Gln Xaa Ser Arg  Trp Gln Met 
    1040                 1045                 1050             


Glu Val  Asp Asn Glu Xaa Pro  Phe Val Xaa Ser Xaa  Ile Ala Xaa 
    1055                 1060                 1065             


Gly Ser  Leu Asn Phe Leu Lys  Asp Asn Xaa Asp Ile  Tyr Val Gly 
    1070                 1075                 1080             


Asp Arg  Ala Ile Asp Asn Ile  Lys Gly Leu Gln Gly  Cys Leu Ser 
    1085                 1090                 1095             


Xaa Ile  Glu Ile Gly Gly Ile  Tyr Leu Ser Tyr Phe  Glu Asn Val 
    1100                 1105                 1110             


His Gly  Phe Ile Asn Lys Pro  Gln Glu Glu Gln Phe  Leu Lys Ile 
    1115                 1120                 1125             


Ser Xaa  Asn Ser Val Val Xaa  Gly Cys Leu Gln Leu  Asn Val Cys 
    1130                 1135                 1140             


Asn Ser  Asn Pro Cys Leu His  Gly Gly Asn Cys Glu  Asp Ile Tyr 
    1145                 1150                 1155             


Ser Ser  Tyr His Cys Ser Cys  Pro Leu Gly Trp Ser  Gly Lys His 
    1160                 1165                 1170             


Cys Glu  Leu Asn Ile Asp Glu  Cys Phe Ser Asn Pro  Cys Ile His 
    1175                 1180                 1185             


Gly Asn  Cys Ser Asp Arg Val  Ala Ala Tyr His Cys  Xaa Cys Glu 
    1190                 1195                 1200             


Pro Gly  Tyr Xaa Gly Val Asn  Cys Glu Val Asp Ile  Asp Asn Cys 
    1205                 1210                 1215             


Gln Ser  His Gln Cys Ala Asn  Gly Ala Xaa Cys Ile  Ser His Xaa 
    1220                 1225                 1230             


Asn Gly  Tyr Ser Cys Leu Cys  Phe Gly Asn Phe Xaa  Gly Lys Phe 
    1235                 1240                 1245             


Cys Arg  Gln Ser Arg Leu Pro  Ser Xaa Val Cys Gly  Asn Glu Lys 
    1250                 1255                 1260             


Xaa Asn  Leu Xaa Cys Tyr Asn  Gly Gly Asn Cys Xaa  Glu Phe Gln 
    1265                 1270                 1275             


Xaa Glu  Leu Lys Cys Met Cys  Arg Pro Gly Phe Xaa  Gly Glu Trp 
    1280                 1285                 1290             


Cys Glu  Lys Asp Ile Asp Glu  Cys Ala Ser Asp Pro  Cys Val Asn 
    1295                 1300                 1305             


Gly Gly  Leu Cys Gln Asp Leu  Leu Asn Lys Phe Gln  Cys Leu Cys 
    1310                 1315                 1320             


Asp Val  Ala Phe Ala Gly Glu  Arg Cys Glu Val Asp  Val Ser Ser 
    1325                 1330                 1335             


Leu Ser  Phe Tyr Val Ser Leu  Leu Phe Trp Gln Asn  Leu Phe Gln 
    1340                 1345                 1350             


Leu Leu  Ser Tyr Leu Ile Leu  Arg Met Asn Asp Glu  Pro Val Val 
    1355                 1360                 1365             


Glu Trp  Gly Glu Gln Glu Asp  Tyr 
    1370                 1375     


<210> 6841
<211> 1406
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1063)..(1063)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1201)..(1201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1245)..(1245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1267)..(1267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1275)..(1275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1346)..(1347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1369)..(1369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1375)..(1375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1378)..(1378)
<223> Selenocysteine

<400> 6841
Met Ala Leu Lys Asn Ile Asn Tyr Leu Leu Ile Phe Tyr Leu Ser Phe 
1               5                   10                  15      


Ser Leu Leu Ile Tyr Ile Lys Asn Ser Phe Cys Asn Lys Asn Asn Xaa 
            20                  25                  30          


Arg Cys Leu Ser Asn Ser Cys Gln Asn Asn Ser Xaa Cys Lys Asp Phe 
        35                  40                  45              


Ser Lys Asp Asn Asp Cys Ser Cys Ser Asp Xaa Ala Asn Asn Leu Asp 
    50                  55                  60                  


Lys Asp Cys Asp Asn Met Lys Asp Pro Cys Phe Ser Asn Pro Cys Gln 
65                  70                  75                  80  


Gly Ser Ala Xaa Cys Val Asn Xaa Pro Gly Glu Arg Ser Phe Leu Cys 
                85                  90                  95      


Lys Cys Pro Pro Gly Tyr Ser Gly Xaa Ile Cys Glu Xaa Xaa Ile Gly 
            100                 105                 110         


Ser Cys Gly Lys Asn Ser Cys Gln His Gly Gly Ile Cys His Gln Asp 
        115                 120                 125             


Pro Ile Tyr Pro Val Cys Ile Cys Pro Ala Gly Tyr Ala Gly Arg Phe 
    130                 135                 140                 


Cys Glu Ile Asp His Asp Glu Cys Ala Ser Ser Pro Cys Gln Asn Gly 
145                 150                 155                 160 


Ala Val Cys Gln Asp Gly Ile Asp Gly Tyr Ser Cys Phe Cys Val Pro 
                165                 170                 175     


Gly Tyr Gln Gly Arg His Cys Asp Leu Glu Val Asp Glu Cys Ala Ser 
            180                 185                 190         


Asp Pro Cys Lys Asn Glu Ala Xaa Cys Leu Asn Glu Ile Gly Arg Tyr 
        195                 200                 205             


Xaa Cys Ile Cys Pro His Asn Tyr Ser Gly Val Asn Cys Glu Leu Glu 
    210                 215                 220                 


Ile Asp Glu Cys Trp Ser Gln Pro Cys Leu Asn Gly Ala Xaa Cys Gln 
225                 230                 235                 240 


Asp Ala Leu Gly Ala Tyr Phe Cys Asp Cys Ala Pro Gly Phe Leu Gly 
                245                 250                 255     


Asp His Cys Glu Leu Asn Xaa Asp Glu Cys Ala Ser Gln Pro Cys Leu 
            260                 265                 270         


His Gly Gly Leu Cys Val Asp Gly Glu Asn Arg Tyr Ser Cys Asn Cys 
        275                 280                 285             


Xaa Gly Ser Gly Phe Xaa Gly Xaa His Cys Glu Xaa Leu Met Pro Leu 
    290                 295                 300                 


Cys Trp Ser Lys Pro Cys His Asn Asn Ala Xaa Cys Glu Asp Ser Val 
305                 310                 315                 320 


Asp Asn Tyr Xaa Cys His Cys Trp Pro Gly Tyr Xaa Gly Ala Gln Cys 
                325                 330                 335     


Glu Ile Asp Leu Asn Glu Cys Asn Ser Asn Pro Cys Gln Ser Asn Gly 
            340                 345                 350         


Glu Cys Val Glu Leu Ser Ser Glu Lys Gln Tyr Gly Arg Ile Xaa Gly 
        355                 360                 365             


Leu Pro Ser Ser Phe Ser Tyr His Glu Ala Ser Gly Tyr Val Cys Ile 
    370                 375                 380                 


Cys Gln Pro Gly Phe Xaa Gly Ile His Cys Glu Glu Asp Val Asn Glu 
385                 390                 395                 400 


Cys Ser Ser Asn Pro Cys Gln Asn Gly Gly Xaa Cys Glu Asn Leu Pro 
                405                 410                 415     


Gly Asn Tyr Xaa Cys His Cys Pro Phe Asp Asn Leu Ser Arg Xaa Phe 
            420                 425                 430         


Tyr Gly Gly Arg Asp Cys Ser Asp Ile Leu Leu Gly Cys Xaa His Gln 
        435                 440                 445             


Gln Cys Leu Asn Asn Gly Xaa Cys Ile Pro His Phe Gln Asp Gly Gln 
    450                 455                 460                 


His Gly Phe Ser Cys Leu Cys Pro Ser Gly Tyr Xaa Gly Ser Leu Cys 
465                 470                 475                 480 


Glu Ile Ala Xaa Xaa Leu Ser Phe Glu Gly Asp Gly Phe Leu Trp Val 
                485                 490                 495     


Lys Ser Gly Ser Val Xaa Xaa Lys Gly Ser Val Cys Asn Ile Ala Leu 
            500                 505                 510         


Arg Phe Gln Xaa Val Gln Pro Met Ala Leu Leu Leu Phe Arg Ser Asn 
        515                 520                 525             


Arg Asp Val Phe Val Lys Leu Glu Leu Leu Ser Gly Tyr Ile His Leu 
    530                 535                 540                 


Ser Ile Gln Val Asn Asn Gln Ser Lys Val Leu Leu Phe Ile Ser His 
545                 550                 555                 560 


Asn Xaa Ser Asp Gly Glu Trp His Phe Val Glu Val Ile Phe Ala Glu 
                565                 570                 575     


Ala Val Xaa Leu Xaa Leu Ile Asp Asp Ser Cys Lys Glu Lys Cys Ile 
            580                 585                 590         


Ala Lys Ala Pro Xaa Pro Leu Glu Ser Asp Gln Ser Ile Cys Ala Phe 
        595                 600                 605             


Gln Asn Ser Phe Leu Gly Gly Leu Pro Val Gly Met Xaa Ser Asn Gly 
    610                 615                 620                 


Val Ala Leu Leu Asn Phe Tyr Asn Met Pro Ser Xaa Pro Ser Phe Val 
625                 630                 635                 640 


Gly Cys Leu Gln Asp Ile Lys Ile Asp Trp Asn His Ile Xaa Leu Glu 
                645                 650                 655     


Asn Ile Ser Ser Gly Ser Ser Leu Asn Val Lys Ala Gly Cys Val Arg 
            660                 665                 670         


Lys Asp Trp Cys Glu Ser Gln Pro Cys Gln Ser Arg Gly Arg Cys Ile 
        675                 680                 685             


Asn Leu Trp Leu Ser Tyr Gln Cys Asp Cys His Arg Pro Tyr Glu Gly 
    690                 695                 700                 


Pro Asn Cys Leu Arg Glu Tyr Val Ala Gly Arg Phe Gly Gln Asp Asp 
705                 710                 715                 720 


Ser Xaa Gly Tyr Val Ile Phe Xaa Leu Asp Glu Ser Tyr Gly Asp Xaa 
                725                 730                 735     


Ile Ser Leu Ser Met Phe Val Arg Xaa Leu Gln Pro Ser Gly Leu Leu 
            740                 745                 750         


Leu Ala Leu Glu Asn Ser Xaa Tyr Gln Tyr Ile Arg Val Trp Leu Glu 
        755                 760                 765             


Arg Gly Arg Leu Ala Met Leu Xaa Pro Asn Ser Pro Lys Leu Val Val 
    770                 775                 780                 


Lys Phe Val Leu Asn Asp Gly Asn Val His Leu Ile Ser Leu Lys Ile 
785                 790                 795                 800 


Lys Pro Tyr Lys Ile Glu Leu Tyr Gln Ser Ser Gln Asn Leu Gly Phe 
                805                 810                 815     


Ile Ser Ala Ser Xaa Trp Lys Ile Glu Lys Gly Asp Val Ile Tyr Ile 
            820                 825                 830         


Gly Gly Leu Pro Asp Lys Gln Glu Xaa Glu Leu Asn Gly Gly Phe Phe 
        835                 840                 845             


Lys Gly Cys Ile Gln Asp Val Arg Leu Asn Asn Gln Asn Leu Glu Phe 
    850                 855                 860                 


Phe Pro Asn Pro Xaa Asn Asn Ala Ser Leu Asn Pro Val Leu Val Asn 
865                 870                 875                 880 


Val Xaa Gln Gly Cys Ala Gly Asp Asn Ser Cys Lys Ser Asn Pro Cys 
                885                 890                 895     


His Asn Gly Gly Val Cys His Ser Arg Trp Asp Asp Phe Ser Cys Ser 
            900                 905                 910         


Cys Pro Ala Leu Xaa Ser Gly Lys Ala Cys Glu Glu Val Gln Trp Cys 
        915                 920                 925             


Gly Phe Ser Pro Cys Pro His Gly Ala Gln Cys Gln Pro Val Leu Gln 
    930                 935                 940                 


Gly Phe Glu Cys Ile Ala Asn Ala Val Phe Asn Gly Gln Ser Gly Gln 
945                 950                 955                 960 


Ile Leu Phe Arg Ser Asn Gly Asn Ile Xaa Arg Glu Leu Xaa Asn Ile 
                965                 970                 975     


Xaa Phe Gly Phe Arg Xaa Arg Asp Ala Asn Val Ile Ile Leu His Ala 
            980                 985                 990         


Glu Lys Glu Pro Glu Phe Leu Asn  Ile Ser Ile Gln Asp  Ser Arg Leu 
        995                 1000                 1005             


Phe Phe  Gln Leu Gln Ser Gly  Asn Ser Phe Tyr Met  Leu Ser Leu 
    1010                 1015                 1020             


Xaa Ser  Leu Gln Ser Val Asn  Asp Gly Xaa Trp His  Glu Val Xaa 
    1025                 1030                 1035             


Leu Ser  Met Xaa Asp Pro Leu  Ser Gln Xaa Ser Arg  Trp Gln Met 
    1040                 1045                 1050             


Glu Val  Asp Asn Glu Xaa Pro  Phe Val Xaa Ser Xaa  Ile Ala Xaa 
    1055                 1060                 1065             


Gly Ser  Leu Asn Phe Leu Lys  Asp Asn Xaa Asp Ile  Tyr Val Gly 
    1070                 1075                 1080             


Asp Arg  Ala Ile Asp Asn Ile  Lys Gly Leu Gln Gly  Cys Leu Ser 
    1085                 1090                 1095             


Xaa Ile  Glu Ile Gly Gly Ile  Tyr Leu Ser Tyr Phe  Glu Asn Val 
    1100                 1105                 1110             


His Gly  Phe Ile Asn Lys Pro  Gln Glu Glu Gln Phe  Leu Lys Ile 
    1115                 1120                 1125             


Ser Xaa  Asn Ser Val Val Xaa  Gly Cys Leu Gln Leu  Asn Val Cys 
    1130                 1135                 1140             


Asn Ser  Asn Pro Cys Leu His  Gly Gly Asn Cys Glu  Asp Ile Tyr 
    1145                 1150                 1155             


Ser Ser  Tyr His Cys Ser Cys  Pro Leu Gly Trp Ser  Gly Lys His 
    1160                 1165                 1170             


Cys Glu  Leu Asn Ile Asp Glu  Cys Phe Ser Asn Pro  Cys Ile His 
    1175                 1180                 1185             


Gly Asn  Cys Ser Asp Arg Val  Ala Ala Tyr His Cys  Xaa Cys Glu 
    1190                 1195                 1200             


Pro Gly  Tyr Xaa Gly Val Asn  Cys Glu Val Asp Ile  Asp Asn Cys 
    1205                 1210                 1215             


Gln Ser  His Gln Cys Ala Asn  Gly Ala Xaa Cys Ile  Ser His Xaa 
    1220                 1225                 1230             


Asn Gly  Tyr Ser Cys Leu Cys  Phe Gly Asn Phe Xaa  Gly Lys Phe 
    1235                 1240                 1245             


Cys Arg  Gln Ser Arg Leu Pro  Ser Xaa Val Cys Gly  Asn Glu Lys 
    1250                 1255                 1260             


Xaa Asn  Leu Xaa Cys Tyr Asn  Gly Gly Asn Cys Xaa  Glu Phe Gln 
    1265                 1270                 1275             


Xaa Glu  Leu Lys Cys Met Cys  Arg Pro Gly Phe Xaa  Gly Glu Trp 
    1280                 1285                 1290             


Cys Glu  Lys Asp Ile Asp Glu  Cys Ala Ser Asp Pro  Cys Val Asn 
    1295                 1300                 1305             


Gly Gly  Leu Cys Gln Asp Leu  Leu Asn Lys Phe Gln  Cys Leu Cys 
    1310                 1315                 1320             


Asp Val  Ala Phe Ala Gly Glu  Arg Cys Glu Val Asp  Leu Ala Asp 
    1325                 1330                 1335             


Asp Leu  Ile Ser Asp Ile Phe  Xaa Xaa Ile Gly Ser  Val Xaa Val 
    1340                 1345                 1350             


Ala Leu  Leu Leu Ile Leu Leu  Leu Ala Ile Val Ala  Ser Val Val 
    1355                 1360                 1365             


Xaa Ser  Asn Lys Arg Ala Xaa  Gln Gly Xaa Tyr Ser  Pro Ser Arg 
    1370                 1375                 1380             


Gln Glu  Lys Glu Gly Ser Arg  Val Glu Met Trp Asn  Leu Met Pro 
    1385                 1390                 1395             


Pro Pro  Ala Met Glu Arg Leu  Ile 
    1400                 1405     


<210> 6842
<211> 1294
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(926)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (930)..(930)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1089)..(1089)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1145)..(1145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1152)..(1152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1167)..(1167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1234)..(1235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1240)..(1240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<400> 6842
Met Ala Leu Lys Asn Ile Asn Tyr Leu Leu Ile Phe Tyr Leu Ser Phe 
1               5                   10                  15      


Ser Leu Leu Ile Tyr Ile Lys Asn Ser Phe Cys Asn Lys Asn Asn Xaa 
            20                  25                  30          


Arg Cys Leu Ser Asn Ser Cys Gln Asn Asn Ser Xaa Cys Lys Asp Phe 
        35                  40                  45              


Ser Lys Asp Asn Asp Cys Ser Cys Ser Asp Xaa Ala Asn Asn Leu Asp 
    50                  55                  60                  


Lys Asp Cys Asp Asn Met Lys Asp Pro Cys Phe Ser Asn Pro Cys Gln 
65                  70                  75                  80  


Gly Ser Ala Xaa Cys Val Asn Xaa Pro Gly Glu Arg Ser Phe Leu Cys 
                85                  90                  95      


Lys Cys Pro Pro Gly Tyr Ser Gly Xaa Ile Cys Glu Xaa Xaa Ile Gly 
            100                 105                 110         


Ser Cys Gly Lys Asn Ser Cys Gln His Gly Gly Ile Cys His Gln Asp 
        115                 120                 125             


Pro Ile Tyr Pro Val Cys Ile Cys Pro Ala Gly Tyr Ala Gly Arg Phe 
    130                 135                 140                 


Cys Glu Ile Asp His Asp Glu Cys Ala Ser Ser Pro Cys Gln Asn Gly 
145                 150                 155                 160 


Ala Val Cys Gln Asp Gly Ile Asp Gly Tyr Ser Cys Phe Cys Val Pro 
                165                 170                 175     


Gly Tyr Gln Gly Arg His Cys Asp Leu Glu Val Asp Glu Cys Ala Ser 
            180                 185                 190         


Asp Pro Cys Lys Asn Glu Ala Xaa Cys Leu Asn Glu Ile Gly Arg Tyr 
        195                 200                 205             


Xaa Cys Ile Cys Pro His Asn Tyr Ser Gly Tyr Xaa Gly Ala Gln Cys 
    210                 215                 220                 


Glu Ile Asp Leu Asn Glu Cys Asn Ser Asn Pro Cys Gln Ser Asn Gly 
225                 230                 235                 240 


Glu Cys Val Glu Leu Ser Ser Glu Lys Gln Tyr Gly Arg Ile Xaa Gly 
                245                 250                 255     


Leu Pro Ser Ser Phe Ser Tyr His Glu Ala Ser Gly Tyr Val Cys Ile 
            260                 265                 270         


Cys Gln Pro Gly Phe Xaa Gly Ile His Cys Glu Glu Asp Val Asn Glu 
        275                 280                 285             


Cys Ser Ser Asn Pro Cys Gln Asn Gly Gly Xaa Cys Glu Asn Leu Pro 
    290                 295                 300                 


Gly Asn Tyr Xaa Cys His Cys Pro Phe Asp Asn Leu Ser Arg Xaa Phe 
305                 310                 315                 320 


Tyr Gly Gly Arg Asp Cys Ser Asp Ile Leu Leu Gly Cys Xaa His Gln 
                325                 330                 335     


Gln Cys Leu Asn Asn Gly Xaa Cys Ile Pro His Phe Gln Asp Gly Gln 
            340                 345                 350         


His Gly Phe Ser Cys Leu Cys Pro Ser Gly Tyr Xaa Gly Ser Leu Cys 
        355                 360                 365             


Glu Ile Ala Xaa Xaa Leu Ser Phe Glu Gly Asp Gly Phe Leu Trp Val 
    370                 375                 380                 


Lys Ser Gly Ser Val Xaa Xaa Lys Gly Ser Val Cys Asn Ile Ala Leu 
385                 390                 395                 400 


Arg Phe Gln Xaa Val Gln Pro Met Ala Leu Leu Leu Phe Arg Ser Asn 
                405                 410                 415     


Arg Asp Val Phe Val Lys Leu Glu Leu Leu Ser Gly Tyr Ile His Leu 
            420                 425                 430         


Ser Ile Gln Val Asn Asn Gln Ser Lys Val Leu Leu Phe Ile Ser His 
        435                 440                 445             


Asn Xaa Ser Asp Gly Glu Trp His Phe Val Glu Val Ile Phe Ala Glu 
    450                 455                 460                 


Ala Val Xaa Leu Xaa Leu Ile Asp Asp Ser Cys Lys Glu Lys Cys Ile 
465                 470                 475                 480 


Ala Lys Ala Pro Xaa Pro Leu Glu Ser Asp Gln Ser Ile Cys Ala Phe 
                485                 490                 495     


Gln Asn Ser Phe Leu Gly Gly Leu Pro Val Gly Met Xaa Ser Asn Gly 
            500                 505                 510         


Val Ala Leu Leu Asn Phe Tyr Asn Met Pro Ser Xaa Pro Ser Phe Val 
        515                 520                 525             


Gly Cys Leu Gln Asp Ile Lys Ile Asp Trp Asn His Ile Xaa Leu Glu 
    530                 535                 540                 


Asn Ile Ser Ser Gly Ser Ser Leu Asn Val Lys Ala Gly Cys Val Arg 
545                 550                 555                 560 


Lys Asp Trp Cys Glu Ser Gln Pro Cys Gln Ser Arg Gly Arg Cys Ile 
                565                 570                 575     


Asn Leu Trp Leu Ser Tyr Gln Cys Asp Cys His Arg Pro Tyr Glu Gly 
            580                 585                 590         


Pro Asn Cys Leu Arg Glu Tyr Val Ala Gly Arg Phe Gly Gln Asp Asp 
        595                 600                 605             


Ser Xaa Gly Tyr Val Ile Phe Xaa Leu Asp Glu Ser Tyr Gly Asp Xaa 
    610                 615                 620                 


Ile Ser Leu Ser Met Phe Val Arg Xaa Leu Gln Pro Ser Gly Leu Leu 
625                 630                 635                 640 


Leu Ala Leu Glu Asn Ser Xaa Tyr Gln Tyr Ile Arg Val Trp Leu Glu 
                645                 650                 655     


Arg Gly Arg Leu Ala Met Leu Xaa Pro Asn Ser Pro Lys Leu Val Val 
            660                 665                 670         


Lys Phe Val Leu Asn Asp Gly Asn Val His Leu Ile Ser Leu Lys Ile 
        675                 680                 685             


Lys Pro Tyr Lys Ile Glu Leu Tyr Gln Ser Ser Gln Asn Leu Gly Phe 
    690                 695                 700                 


Ile Ser Ala Ser Xaa Trp Lys Ile Glu Lys Gly Asp Val Ile Tyr Ile 
705                 710                 715                 720 


Gly Gly Leu Pro Asp Lys Gln Glu Xaa Glu Leu Asn Gly Gly Phe Phe 
                725                 730                 735     


Lys Gly Cys Ile Gln Asp Val Arg Leu Asn Asn Gln Asn Leu Glu Phe 
            740                 745                 750         


Phe Pro Asn Pro Xaa Asn Asn Ala Ser Leu Asn Pro Val Leu Val Asn 
        755                 760                 765             


Val Xaa Gln Gly Cys Ala Gly Asp Asn Ser Cys Lys Ser Asn Pro Cys 
    770                 775                 780                 


His Asn Gly Gly Val Cys His Ser Arg Trp Asp Asp Phe Ser Cys Ser 
785                 790                 795                 800 


Cys Pro Ala Leu Xaa Ser Gly Lys Ala Cys Glu Glu Val Gln Trp Cys 
                805                 810                 815     


Gly Phe Ser Pro Cys Pro His Gly Ala Gln Cys Gln Pro Val Leu Gln 
            820                 825                 830         


Gly Phe Glu Cys Ile Ala Asn Ala Val Phe Asn Gly Gln Ser Gly Gln 
        835                 840                 845             


Ile Leu Phe Arg Ser Asn Gly Asn Ile Xaa Arg Glu Leu Xaa Asn Ile 
    850                 855                 860                 


Xaa Phe Gly Phe Arg Xaa Arg Asp Ala Asn Val Ile Ile Leu His Ala 
865                 870                 875                 880 


Glu Lys Glu Pro Glu Phe Leu Asn Ile Ser Ile Gln Asp Ser Arg Leu 
                885                 890                 895     


Phe Phe Gln Leu Gln Ser Gly Asn Ser Phe Tyr Met Leu Ser Leu Xaa 
            900                 905                 910         


Ser Leu Gln Ser Val Asn Asp Gly Xaa Trp His Glu Val Xaa Leu Ser 
        915                 920                 925             


Met Xaa Asp Pro Leu Ser Gln Xaa Ser Arg Trp Gln Met Glu Val Asp 
    930                 935                 940                 


Asn Glu Xaa Pro Phe Val Xaa Ser Xaa Ile Ala Xaa Gly Ser Leu Asn 
945                 950                 955                 960 


Phe Leu Lys Asp Asn Xaa Asp Ile Tyr Val Gly Asp Arg Ala Ile Asp 
                965                 970                 975     


Asn Ile Lys Gly Leu Gln Gly Cys Leu Ser Xaa Ile Glu Ile Gly Gly 
            980                 985                 990         


Ile Tyr Leu Ser Tyr Phe Glu Asn  Val His Gly Phe Ile  Asn Lys Pro 
        995                 1000                 1005             


Gln Glu  Glu Gln Phe Leu Lys  Ile Ser Xaa Asn Ser  Val Val Xaa 
    1010                 1015                 1020             


Gly Cys  Leu Gln Leu Asn Val  Cys Asn Ser Asn Pro  Cys Leu His 
    1025                 1030                 1035             


Gly Gly  Asn Cys Glu Asp Ile  Tyr Ser Ser Tyr His  Cys Ser Cys 
    1040                 1045                 1050             


Pro Leu  Gly Trp Ser Gly Lys  His Cys Glu Leu Asn  Ile Asp Glu 
    1055                 1060                 1065             


Cys Phe  Ser Asn Pro Cys Ile  His Gly Asn Cys Ser  Asp Arg Val 
    1070                 1075                 1080             


Ala Ala  Tyr His Cys Xaa Cys  Glu Pro Gly Tyr Xaa  Gly Val Asn 
    1085                 1090                 1095             


Cys Glu  Val Asp Ile Asp Asn  Cys Gln Ser His Gln  Cys Ala Asn 
    1100                 1105                 1110             


Gly Ala  Xaa Cys Ile Ser His  Xaa Asn Gly Tyr Ser  Cys Leu Cys 
    1115                 1120                 1125             


Phe Gly  Asn Phe Xaa Gly Lys  Phe Cys Arg Gln Ser  Arg Leu Pro 
    1130                 1135                 1140             


Ser Xaa  Val Cys Gly Asn Glu  Lys Xaa Asn Leu Xaa  Cys Tyr Asn 
    1145                 1150                 1155             


Gly Gly  Asn Cys Xaa Glu Phe  Gln Xaa Glu Leu Lys  Cys Met Cys 
    1160                 1165                 1170             


Arg Pro  Gly Phe Xaa Gly Glu  Trp Cys Glu Lys Asp  Ile Asp Glu 
    1175                 1180                 1185             


Cys Ala  Ser Asp Pro Cys Val  Asn Gly Gly Leu Cys  Gln Asp Leu 
    1190                 1195                 1200             


Leu Asn  Lys Phe Gln Cys Leu  Cys Asp Val Ala Phe  Ala Gly Glu 
    1205                 1210                 1215             


Arg Cys  Glu Val Asp Leu Ala  Asp Asp Leu Ile Ser  Asp Ile Phe 
    1220                 1225                 1230             


Xaa Xaa  Ile Gly Ser Val Xaa  Val Ala Leu Leu Leu  Ile Leu Leu 
    1235                 1240                 1245             


Leu Ala  Ile Val Ala Ser Val  Val Xaa Ser Asn Lys  Arg Ala Xaa 
    1250                 1255                 1260             


Gln Gly  Xaa Tyr Ser Pro Ser  Arg Gln Glu Lys Glu  Gly Ser Arg 
    1265                 1270                 1275             


Val Glu  Met Trp Asn Leu Met  Pro Pro Pro Ala Met  Glu Arg Leu 
    1280                 1285                 1290             


Ile 
    


<210> 6843
<211> 1382
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (946)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (953)..(953)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1014)..(1014)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1039)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1044)..(1044)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1106)..(1106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1221)..(1221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1240)..(1240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1243)..(1243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1255)..(1255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1322)..(1323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1328)..(1328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1354)..(1354)
<223> Selenocysteine

<400> 6843
Met Lys Asp Pro Cys Phe Ser Asn Pro Cys Gln Gly Ser Ala Xaa Cys 
1               5                   10                  15      


Val Asn Xaa Pro Gly Glu Arg Ser Phe Leu Cys Lys Cys Pro Pro Gly 
            20                  25                  30          


Tyr Ser Gly Xaa Ile Cys Glu Xaa Xaa Ile Gly Ser Cys Gly Lys Asn 
        35                  40                  45              


Ser Cys Gln His Gly Gly Ile Cys His Gln Asp Pro Ile Tyr Pro Val 
    50                  55                  60                  


Cys Ile Cys Pro Ala Gly Tyr Ala Gly Arg Phe Cys Glu Ile Asp His 
65                  70                  75                  80  


Asp Glu Cys Ala Ser Ser Pro Cys Gln Asn Gly Ala Val Cys Gln Asp 
                85                  90                  95      


Gly Ile Asp Gly Tyr Ser Cys Phe Cys Val Pro Gly Tyr Gln Gly Arg 
            100                 105                 110         


His Cys Asp Leu Glu Val Asp Glu Cys Ala Ser Asp Pro Cys Lys Asn 
        115                 120                 125             


Glu Ala Xaa Cys Leu Asn Glu Ile Gly Arg Tyr Xaa Cys Ile Cys Pro 
    130                 135                 140                 


His Asn Tyr Ser Gly Val Asn Cys Glu Leu Glu Ile Asp Glu Cys Trp 
145                 150                 155                 160 


Ser Gln Pro Cys Leu Asn Gly Ala Xaa Cys Gln Asp Ala Leu Gly Ala 
                165                 170                 175     


Tyr Phe Cys Asp Cys Ala Pro Gly Phe Leu Gly Asp His Cys Glu Leu 
            180                 185                 190         


Asn Xaa Asp Glu Cys Ala Ser Gln Pro Cys Leu His Gly Gly Leu Cys 
        195                 200                 205             


Val Asp Gly Glu Asn Arg Tyr Ser Cys Asn Cys Xaa Gly Ser Gly Phe 
    210                 215                 220                 


Xaa Gly Xaa His Cys Glu Xaa Leu Met Pro Leu Cys Trp Ser Lys Pro 
225                 230                 235                 240 


Cys His Asn Asn Ala Xaa Cys Glu Asp Ser Val Asp Asn Tyr Xaa Cys 
                245                 250                 255     


His Cys Trp Pro Gly Tyr Xaa Gly Ala Gln Cys Glu Ile Asp Leu Asn 
            260                 265                 270         


Glu Cys Asn Ser Asn Pro Cys Gln Ser Asn Gly Glu Cys Val Glu Leu 
        275                 280                 285             


Ser Ser Glu Lys Gln Tyr Gly Arg Ile Xaa Gly Leu Pro Ser Ser Phe 
    290                 295                 300                 


Ser Tyr His Glu Ala Ser Gly Tyr Val Cys Ile Cys Gln Pro Gly Phe 
305                 310                 315                 320 


Xaa Gly Ile His Cys Glu Glu Asp Val Asn Glu Cys Ser Ser Asn Pro 
                325                 330                 335     


Cys Gln Asn Gly Gly Xaa Cys Glu Asn Leu Pro Gly Asn Tyr Xaa Cys 
            340                 345                 350         


His Cys Pro Phe Asp Asn Leu Ser Arg Xaa Phe Tyr Gly Gly Arg Asp 
        355                 360                 365             


Cys Ser Asp Ile Leu Leu Gly Cys Xaa His Gln Gln Cys Leu Asn Asn 
    370                 375                 380                 


Gly Xaa Cys Ile Pro His Phe Gln Asp Gly Gln His Gly Phe Ser Cys 
385                 390                 395                 400 


Leu Cys Pro Ser Gly Tyr Xaa Gly Ser Leu Cys Glu Ile Ala Xaa Xaa 
                405                 410                 415     


Leu Ser Phe Glu Gly Asp Gly Phe Leu Trp Val Lys Ser Gly Ser Val 
            420                 425                 430         


Xaa Xaa Lys Gly Ser Val Cys Asn Ile Ala Leu Arg Phe Gln Xaa Val 
        435                 440                 445             


Gln Pro Met Ala Leu Leu Leu Phe Arg Ser Asn Arg Asp Val Phe Val 
    450                 455                 460                 


Lys Leu Glu Leu Leu Ser Gly Tyr Ile His Leu Ser Ile Gln Val Asn 
465                 470                 475                 480 


Asn Gln Ser Lys Val Leu Leu Phe Ile Ser His Asn Xaa Ser Asp Gly 
                485                 490                 495     


Glu Trp His Phe Val Glu Val Ile Phe Ala Glu Ala Val Xaa Leu Xaa 
            500                 505                 510         


Leu Ile Asp Asp Ser Cys Lys Glu Lys Cys Ile Ala Lys Ala Pro Xaa 
        515                 520                 525             


Pro Leu Glu Ser Asp Gln Ser Ile Cys Ala Phe Gln Asn Ser Phe Leu 
    530                 535                 540                 


Gly Gly Leu Pro Val Gly Met Xaa Ser Asn Gly Val Ala Leu Leu Asn 
545                 550                 555                 560 


Phe Tyr Asn Met Pro Ser Xaa Pro Ser Phe Val Gly Cys Leu Gln Asp 
                565                 570                 575     


Ile Lys Ile Asp Trp Asn His Ile Xaa Leu Glu Asn Ile Ser Ser Gly 
            580                 585                 590         


Ser Ser Leu Asn Val Lys Ala Gly Cys Val Arg Lys Asp Trp Cys Glu 
        595                 600                 605             


Ser Gln Pro Cys Gln Ser Arg Gly Arg Cys Ile Asn Leu Trp Leu Ser 
    610                 615                 620                 


Tyr Gln Cys Asp Cys His Arg Pro Tyr Glu Gly Pro Asn Cys Leu Arg 
625                 630                 635                 640 


Glu Tyr Val Ala Gly Arg Phe Gly Gln Asp Asp Ser Xaa Gly Tyr Val 
                645                 650                 655     


Ile Phe Xaa Leu Asp Glu Ser Tyr Gly Asp Xaa Ile Ser Leu Ser Met 
            660                 665                 670         


Phe Val Arg Xaa Leu Gln Pro Ser Gly Leu Leu Leu Ala Leu Glu Asn 
        675                 680                 685             


Ser Xaa Tyr Gln Tyr Ile Arg Val Trp Leu Glu Arg Gly Arg Leu Ala 
    690                 695                 700                 


Met Leu Xaa Pro Asn Ser Pro Lys Leu Val Val Lys Phe Val Leu Asn 
705                 710                 715                 720 


Asp Gly Asn Val His Leu Ile Ser Leu Lys Ile Lys Pro Tyr Lys Ile 
                725                 730                 735     


Glu Leu Tyr Gln Ser Ser Gln Asn Leu Gly Phe Ile Ser Ala Ser Xaa 
            740                 745                 750         


Trp Lys Ile Glu Lys Gly Asp Val Ile Tyr Ile Gly Gly Leu Pro Asp 
        755                 760                 765             


Lys Gln Glu Xaa Glu Leu Asn Gly Gly Phe Phe Lys Gly Cys Ile Gln 
    770                 775                 780                 


Asp Val Arg Leu Asn Asn Gln Asn Leu Glu Phe Phe Pro Asn Pro Xaa 
785                 790                 795                 800 


Asn Asn Ala Ser Leu Asn Pro Val Leu Val Asn Val Xaa Gln Gly Cys 
                805                 810                 815     


Ala Gly Asp Asn Ser Cys Lys Arg Gln Xaa Asn Val Gly Arg Ala Leu 
            820                 825                 830         


Xaa Glu Leu Gly Ser Arg Gly Pro Lys Tyr Gln Val Ser Leu Phe Arg 
        835                 840                 845             


Phe Cys Val Gly Ser Trp Ala Xaa Gly Asn Xaa Phe Phe Leu Ser Ser 
    850                 855                 860                 


Ile Lys Pro Gly Ser Asn Pro Cys His Asn Gly Gly Val Cys His Ser 
865                 870                 875                 880 


Arg Trp Asp Asp Phe Ser Cys Ser Cys Pro Ala Leu Xaa Ser Gly Lys 
                885                 890                 895     


Ala Cys Glu Glu Val Gln Trp Cys Gly Phe Ser Pro Cys Pro His Gly 
            900                 905                 910         


Ala Gln Cys Gln Pro Val Leu Gln Gly Phe Glu Cys Ile Ala Asn Ala 
        915                 920                 925             


Val Phe Asn Gly Gln Ser Gly Gln Ile Leu Phe Arg Ser Asn Gly Asn 
    930                 935                 940                 


Ile Xaa Arg Glu Leu Xaa Asn Ile Xaa Phe Gly Phe Arg Xaa Arg Asp 
945                 950                 955                 960 


Ala Asn Val Ile Ile Leu His Ala Glu Lys Glu Pro Glu Phe Leu Asn 
                965                 970                 975     


Ile Ser Ile Gln Asp Ser Arg Leu Phe Phe Gln Leu Gln Ser Gly Asn 
            980                 985                 990         


Ser Phe Tyr Met Leu Ser Leu Xaa  Ser Leu Gln Ser Val  Asn Asp Gly 
        995                 1000                 1005             


Xaa Trp  His Glu Val Xaa Leu  Ser Met Xaa Asp Pro  Leu Ser Gln 
    1010                 1015                 1020             


Xaa Ser  Arg Trp Gln Met Glu  Val Asp Asn Glu Xaa  Pro Phe Val 
    1025                 1030                 1035             


Xaa Ser  Xaa Ile Ala Xaa Gly  Ser Leu Asn Phe Leu  Lys Asp Asn 
    1040                 1045                 1050             


Xaa Asp  Ile Tyr Val Gly Asp  Arg Ala Ile Asp Asn  Ile Lys Gly 
    1055                 1060                 1065             


Leu Gln  Gly Cys Leu Ser Xaa  Ile Glu Ile Gly Gly  Ile Tyr Leu 
    1070                 1075                 1080             


Ser Tyr  Phe Glu Asn Val His  Gly Phe Ile Asn Lys  Pro Gln Glu 
    1085                 1090                 1095             


Glu Gln  Phe Leu Lys Ile Ser  Xaa Asn Ser Val Val  Xaa Gly Cys 
    1100                 1105                 1110             


Leu Gln  Leu Asn Val Cys Asn  Ser Asn Pro Cys Leu  His Gly Gly 
    1115                 1120                 1125             


Asn Cys  Glu Asp Ile Tyr Ser  Ser Tyr His Cys Ser  Cys Pro Leu 
    1130                 1135                 1140             


Gly Trp  Ser Gly Lys His Cys  Glu Leu Asn Ile Asp  Glu Cys Phe 
    1145                 1150                 1155             


Ser Asn  Pro Cys Ile His Gly  Asn Cys Ser Asp Arg  Val Ala Ala 
    1160                 1165                 1170             


Tyr His  Cys Xaa Cys Glu Pro  Gly Tyr Xaa Gly Val  Asn Cys Glu 
    1175                 1180                 1185             


Val Asp  Ile Asp Asn Cys Gln  Ser His Gln Cys Ala  Asn Gly Ala 
    1190                 1195                 1200             


Xaa Cys  Ile Ser His Xaa Asn  Gly Tyr Ser Cys Leu  Cys Phe Gly 
    1205                 1210                 1215             


Asn Phe  Xaa Gly Lys Phe Cys  Arg Gln Ser Arg Leu  Pro Ser Xaa 
    1220                 1225                 1230             


Val Cys  Gly Asn Glu Lys Xaa  Asn Leu Xaa Cys Tyr  Asn Gly Gly 
    1235                 1240                 1245             


Asn Cys  Xaa Glu Phe Gln Xaa  Glu Leu Lys Cys Met  Cys Arg Pro 
    1250                 1255                 1260             


Gly Phe  Xaa Gly Glu Trp Cys  Glu Lys Asp Ile Asp  Glu Cys Ala 
    1265                 1270                 1275             


Ser Asp  Pro Cys Val Asn Gly  Gly Leu Cys Gln Asp  Leu Leu Asn 
    1280                 1285                 1290             


Lys Phe  Gln Cys Leu Cys Asp  Val Ala Phe Ala Gly  Glu Arg Cys 
    1295                 1300                 1305             


Glu Val  Asp Leu Ala Asp Asp  Leu Ile Ser Asp Ile  Phe Xaa Xaa 
    1310                 1315                 1320             


Ile Gly  Ser Val Xaa Val Ala  Leu Leu Leu Ile Leu  Leu Leu Ala 
    1325                 1330                 1335             


Ile Val  Ala Ser Val Val Xaa  Ser Asn Lys Arg Ala  Xaa Gln Gly 
    1340                 1345                 1350             


Xaa Tyr  Ser Pro Ser Arg Gln  Glu Lys Glu Gly Ser  Arg Val Glu 
    1355                 1360                 1365             


Met Trp  Asn Leu Met Pro Pro  Pro Ala Met Glu Arg  Leu Ile 
    1370                 1375                 1380         


<210> 6844
<211> 674
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<400> 6844
Met Xaa Ser Asn Gly Val Ala Leu Leu Asn Phe Tyr Asn Met Pro Ser 
1               5                   10                  15      


Xaa Pro Ser Phe Val Gly Cys Leu Gln Asp Ile Lys Ile Asp Trp Asn 
            20                  25                  30          


His Ile Xaa Leu Glu Asn Ile Ser Ser Gly Ser Ser Leu Asn Val Lys 
        35                  40                  45              


Ala Gly Cys Val Arg Lys Asp Trp Cys Glu Ser Gln Pro Cys Gln Ser 
    50                  55                  60                  


Arg Gly Arg Cys Ile Asn Leu Trp Leu Ser Tyr Gln Cys Asp Cys His 
65                  70                  75                  80  


Arg Pro Tyr Glu Gly Pro Asn Cys Leu Arg Glu Tyr Val Ala Gly Arg 
                85                  90                  95      


Phe Gly Gln Asp Asp Ser Xaa Gly Tyr Val Ile Phe Xaa Leu Asp Glu 
            100                 105                 110         


Ser Tyr Gly Asp Xaa Ile Ser Leu Ser Met Phe Val Arg Xaa Leu Gln 
        115                 120                 125             


Pro Ser Gly Leu Leu Leu Ala Leu Glu Asn Ser Xaa Tyr Gln Tyr Ile 
    130                 135                 140                 


Arg Val Trp Leu Glu Arg Gly Arg Leu Ala Met Leu Xaa Pro Asn Ser 
145                 150                 155                 160 


Pro Lys Leu Val Val Lys Phe Val Leu Asn Asp Gly Asn Val His Leu 
                165                 170                 175     


Ile Ser Leu Lys Ile Lys Pro Tyr Lys Ile Glu Leu Tyr Gln Ser Ser 
            180                 185                 190         


Gln Asn Leu Gly Phe Ile Ser Ala Ser Xaa Trp Lys Ile Glu Lys Gly 
        195                 200                 205             


Asp Val Ile Tyr Ile Gly Gly Leu Pro Asp Lys Gln Glu Xaa Glu Leu 
    210                 215                 220                 


Asn Gly Gly Phe Phe Lys Gly Cys Ile Gln Asp Val Arg Leu Asn Asn 
225                 230                 235                 240 


Gln Asn Leu Glu Phe Phe Pro Asn Pro Xaa Asn Asn Ala Ser Leu Asn 
                245                 250                 255     


Pro Val Leu Val Asn Val Xaa Gln Gly Cys Ala Gly Asp Asn Ser Cys 
            260                 265                 270         


Lys Ser Asn Pro Cys His Asn Gly Gly Val Cys His Ser Arg Trp Asp 
        275                 280                 285             


Asp Phe Ser Cys Ser Cys Pro Ala Leu Xaa Ser Gly Lys Ala Cys Glu 
    290                 295                 300                 


Glu Val Gln Trp Cys Gly Phe Ser Pro Cys Pro His Gly Ala Gln Cys 
305                 310                 315                 320 


Gln Pro Val Leu Gln Gly Phe Glu Cys Ile Ala Asn Ala Val Phe Asn 
                325                 330                 335     


Gly Gln Ser Gly Gln Ile Leu Phe Arg Ser Asn Gly Asn Ile Xaa Arg 
            340                 345                 350         


Glu Leu Xaa Asn Ile Xaa Phe Gly Phe Arg Xaa Arg Asp Ala Asn Val 
        355                 360                 365             


Ile Ile Leu His Ala Glu Lys Glu Pro Glu Phe Leu Asn Ile Ser Ile 
    370                 375                 380                 


Gln Asp Ser Arg Leu Phe Phe Gln Leu Gln Ser Gly Asn Ser Phe Tyr 
385                 390                 395                 400 


Met Leu Ser Leu Xaa Ser Leu Gln Ser Val Asn Asp Gly Xaa Trp His 
                405                 410                 415     


Glu Val Xaa Leu Ser Met Xaa Asp Pro Leu Ser Gln Xaa Ser Arg Trp 
            420                 425                 430         


Gln Met Glu Val Asp Asn Glu Xaa Pro Phe Val Xaa Ser Xaa Ile Ala 
        435                 440                 445             


Xaa Gly Ser Leu Asn Phe Leu Lys Asp Asn Xaa Asp Ile Tyr Val Gly 
    450                 455                 460                 


Asp Arg Ala Ile Asp Asn Ile Lys Gly Leu Gln Gly Cys Leu Ser Xaa 
465                 470                 475                 480 


Ile Glu Ile Gly Gly Ile Tyr Leu Ser Tyr Phe Glu Asn Val His Gly 
                485                 490                 495     


Phe Ile Asn Lys Pro Gln Glu Glu Gln Phe Leu Lys Ile Ser Xaa Asn 
            500                 505                 510         


Ser Val Val Xaa Gly Cys Leu Gln Leu Asn Val Cys Asn Ser Asn Pro 
        515                 520                 525             


Cys Leu His Gly Gly Asn Cys Glu Asp Ile Tyr Ser Ser Tyr His Cys 
    530                 535                 540                 


Ser Cys Pro Leu Gly Trp Ser Gly Lys His Cys Glu Leu Asn Ile Asp 
545                 550                 555                 560 


Glu Cys Phe Ser Asn Pro Cys Ile His Gly Asn Cys Ser Asp Arg Val 
                565                 570                 575     


Ala Ala Tyr His Cys Xaa Cys Glu Pro Gly Tyr Xaa Gly Val Asn Cys 
            580                 585                 590         


Glu Val Asp Ile Asp Asn Cys Gln Ser His Gln Cys Ala Asn Gly Ala 
        595                 600                 605             


Xaa Cys Ile Ser His Xaa Asn Gly Tyr Ser Cys Leu Cys Phe Gly Asn 
    610                 615                 620                 


Phe Xaa Gly Lys Phe Cys Arg Gln Ser Arg Leu Pro Ser Xaa Val Cys 
625                 630                 635                 640 


Gly Asn Glu Lys Xaa Asn Leu Xaa Cys Tyr Asn Gly Gly Asn Cys Xaa 
                645                 650                 655     


Glu Phe Gln Xaa Glu Leu Lys Cys Met Cys Arg Pro Gly Phe Xaa Gly 
            660                 665                 670         


Glu Trp 
        


<210> 6845
<211> 1176
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (873)..(873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1175)..(1175)
<223> Selenocysteine

<400> 6845
Met Ala Leu Ala Arg Pro Gly Xaa Pro Asp Pro Gln Ala Leu Ala Ser 
1               5                   10                  15      


Val Leu Leu Leu Leu Leu Trp Ala Pro Ala Leu Ser Leu Leu Ala Gly 
            20                  25                  30          


Xaa Val Pro Ser Glu Pro Pro Ser Ala Cys Ala Ser Asp Pro Cys Ala 
        35                  40                  45              


Pro Gly Xaa Glu Cys Gln Ala Xaa Glu Ser Gly Gly Tyr Xaa Cys Gly 
    50                  55                  60                  


Pro Met Glu Pro Arg Gly Cys Ala Xaa Gln Pro Cys His His Gly Ala 
65                  70                  75                  80  


Leu Cys Val Pro Gln Gly Pro Asp Pro Xaa Gly Phe Arg Cys Tyr Cys 
                85                  90                  95      


Val Pro Gly Phe Gln Gly Pro Arg Cys Glu Leu Asp Ile Asp Glu Cys 
            100                 105                 110         


Ala Ser Arg Pro Cys His His Gly Ala Xaa Cys Arg Asn Leu Ala Asp 
        115                 120                 125             


Arg Tyr Glu Cys His Cys Pro Leu Gly Tyr Ala Gly Val Xaa Cys Glu 
    130                 135                 140                 


Met Glu Val Asp Glu Cys Ala Ser Ala Pro Cys Leu His Gly Gly Ser 
145                 150                 155                 160 


Cys Leu Asp Gly Val Gly Ser Phe Arg Cys Val Cys Ala Pro Gly Tyr 
                165                 170                 175     


Gly Gly Xaa Arg Cys Gln Leu Asp Leu Asp Glu Cys Gln Ser Gln Pro 
            180                 185                 190         


Cys Ala His Gly Gly Xaa Cys His Asp Leu Val Asn Gly Phe Arg Cys 
        195                 200                 205             


Asp Cys Ala Gly Xaa Gly Tyr Glu Gly Xaa His Cys Glu Arg Glu Val 
    210                 215                 220                 


Leu Glu Cys Ala Ser Ala Pro Cys Glu His Asn Ala Ser Cys Leu Glu 
225                 230                 235                 240 


Gly Leu Gly Ser Phe Arg Cys Leu Cys Trp Pro Gly Tyr Ser Gly Glu 
                245                 250                 255     


Leu Cys Glu Val Asp Glu Asp Glu Cys Ala Ser Ser Pro Cys Gln His 
            260                 265                 270         


Gly Gly Arg Cys Leu Gln Arg Ser Asp Pro Ala Leu Tyr Gly Gly Val 
        275                 280                 285             


Gln Ala Ala Phe Pro Gly Ala Phe Ser Phe Arg His Ala Ala Gly Phe 
    290                 295                 300                 


Leu Cys His Cys Pro Pro Gly Phe Glu Gly Ala Asp Cys Gly Val Glu 
305                 310                 315                 320 


Val Asp Glu Cys Ala Ser Arg Pro Cys Leu Asn Gly Gly His Cys Gln 
                325                 330                 335     


Asp Leu Pro Asn Gly Phe Gln Cys His Cys Pro Asp Gly Tyr Ala Gly 
            340                 345                 350         


Pro Xaa Cys Glu Glu Asp Val Asp Glu Cys Leu Ser Asp Pro Cys Leu 
        355                 360                 365             


His Gly Gly Xaa Cys Ser Asp Xaa Val Ala Gly Tyr Ile Cys Arg Cys 
    370                 375                 380                 


Pro Glu Xaa Trp Gly Gly Arg Asp Cys Ser Val Gln Leu Xaa Gly Cys 
385                 390                 395                 400 


Gln Gly His Xaa Cys Pro Leu Ala Ala Xaa Cys Ile Pro Ile Phe Glu 
                405                 410                 415     


Ser Gly Val His Ser Tyr Val Cys His Cys Pro Pro Gly Xaa His Gly 
            420                 425                 430         


Pro Phe Cys Gly Gln Asn Xaa Xaa Phe Ser Val Met Ala Gly Ser Pro 
        435                 440                 445             


Ile Gln Ala Ser Val Pro Ala Gly Gly Pro Leu Gly Leu Ala Leu Arg 
    450                 455                 460                 


Phe Arg Xaa Xaa Leu Pro Ala Gly Xaa Leu Ala Xaa Arg Asn Asp Xaa 
465                 470                 475                 480 


Lys Glu Ser Leu Glu Leu Ala Leu Val Ala Ala Xaa Leu Gln Ala Xaa 
                485                 490                 495     


Leu Trp Ser Tyr Ser Xaa Xaa Val Leu Val Leu Arg Leu Pro Asp Leu 
            500                 505                 510         


Ala Leu Asn Asp Gly His Trp His Gln Val Glu Val Val Leu His Leu 
        515                 520                 525             


Ala Xaa Leu Glu Leu Arg Leu Trp His Glu Gly Cys Pro Ala Arg Leu 
    530                 535                 540                 


Cys Val Ala Ser Gly Pro Val Ala Leu Ala Ser Xaa Ala Ser Ala Xaa 
545                 550                 555                 560 


Pro Leu Pro Ala Gly Ile Ser Ser Ala Gln Leu Gly Asp Ala Xaa Phe 
                565                 570                 575     


Ala Gly Cys Leu Gln Asp Val Arg Val Asp Gly His Leu Leu Leu Pro 
            580                 585                 590         


Glu Asp Leu Gly Glu Asn Val Leu Leu Gly Cys Glu Arg Arg Glu Gln 
        595                 600                 605             


Cys Arg Pro Leu Pro Cys Val His Gly Gly Ser Cys Val Asp Leu Trp 
    610                 615                 620                 


Xaa His Phe Arg Cys Asp Cys Ala Arg Pro His Arg Gly Pro Xaa Cys 
625                 630                 635                 640 


Ala Asp Glu Ile Pro Ala Ala Xaa Phe Gly Leu Gly Gly Ala Pro Ser 
                645                 650                 655     


Ser Ala Ser Phe Leu Leu Gln Glu Leu Pro Gly Pro Asn Leu Xaa Val 
            660                 665                 670         


Ser Phe Leu Leu Arg Xaa Arg Glu Ser Ala Gly Leu Leu Leu Gln Phe 
        675                 680                 685             


Ala Asn Asp Ser Ala Ala Gly Leu Xaa Val Phe Leu Ser Glu Gly Arg 
    690                 695                 700                 


Ile Arg Ala Glu Val Pro Gly Ser Pro Ala Val Val Leu Pro Gly Arg 
705                 710                 715                 720 


Trp Asp Asp Gly Leu Arg His Leu Val Met Leu Ser Phe Gly Pro Asp 
                725                 730                 735     


Gln Leu Gln Asp Leu Gly Gln His Val His Val Gly Gly Arg Leu Leu 
            740                 745                 750         


Ala Ala Asp Ser Gln Pro Trp Gly Gly Pro Phe Arg Gly Cys Leu Gln 
        755                 760                 765             


Asp Leu Arg Leu Asp Gly Cys His Leu Pro Phe Phe Pro Leu Pro Leu 
    770                 775                 780                 


Asp Asn Ser Ser Gln Pro Ser Glu Leu Gly Gly Arg Gln Ser Trp Asn 
785                 790                 795                 800 


Leu Xaa Ala Gly Cys Val Ser Glu Asp Met Cys Ser Pro Asp Pro Cys 
                805                 810                 815     


Phe Asn Gly Gly Xaa Cys Leu Val Xaa Trp Asn Asp Phe His Cys Xaa 
            820                 825                 830         


Cys Pro Ala Asn Phe Xaa Gly Pro Xaa Cys Ala Gln Gln Leu Trp Cys 
        835                 840                 845             


Pro Gly Gln Pro Cys Leu Pro Pro Ala Xaa Cys Glu Glu Val Pro Asp 
    850                 855                 860                 


Gly Phe Val Cys Val Ala Glu Ala Xaa Phe Arg Glu Gly Pro Pro Ala 
865                 870                 875                 880 


Ala Phe Ser Gly His Asn Ala Ser Ser Gly Arg Leu Leu Gly Gly Leu 
                885                 890                 895     


Ser Leu Ala Phe Arg Xaa Arg Asp Ser Glu Ala Trp Leu Leu Arg Ala 
            900                 905                 910         


Ala Ala Gly Ala Leu Glu Gly Val Trp Leu Ala Val Arg Asn Gly Ser 
        915                 920                 925             


Leu Ala Gly Gly Val Arg Gly Gly His Gly Leu Pro Gly Ala Val Leu 
    930                 935                 940                 


Pro Ile Pro Gly Pro Arg Val Ala Asp Gly Ala Trp His Arg Val Arg 
945                 950                 955                 960 


Leu Ala Met Glu Arg Pro Ala Ala Xaa Xaa Ser Arg Trp Leu Leu Trp 
                965                 970                 975     


Leu Asp Gly Ala Ala Xaa Pro Val Ala Leu Arg Gly Leu Ala Ser Asp 
            980                 985                 990         


Leu Gly Phe Leu Gln Gly Pro Gly  Ala Val Arg Ile Leu  Leu Ala Glu 
        995                 1000                 1005             


Asn Phe  Xaa Gly Cys Leu Gly  Arg Val Ala Leu Gly  Gly Leu Pro 
    1010                 1015                 1020             


Leu Pro  Leu Ala Arg Pro Arg  Pro Gly Ala Ala Pro  Gly Ala Arg 
    1025                 1030                 1035             


Glu His  Phe Ala Ser Trp Pro  Gly Xaa Pro Ala Pro  Ile Leu Gly 
    1040                 1045                 1050             


Cys Arg  Gly Ala Pro Val Cys  Ala Pro Ser Pro Cys  Leu His Asp 
    1055                 1060                 1065             


Gly Ala  Cys Arg Asp Leu Phe  Asp Ala Phe Ala Cys  Ala Cys Gly 
    1070                 1075                 1080             


Pro Gly  Trp Glu Gly Pro Arg  Cys Glu Ala His Val  Asp Pro Cys 
    1085                 1090                 1095             


His Ser  Ala Pro Cys Ala Arg  Gly Arg Cys His Xaa  His Pro Asp 
    1100                 1105                 1110             


Gly Arg  Phe Glu Cys Arg Cys  Pro Pro Gly Phe Gly  Gly Pro Arg 
    1115                 1120                 1125             


Cys Arg  Trp Asp Gly Trp Ala  Gly Gly Trp Ala Ala  Asn Ala Pro 
    1130                 1135                 1140             


Trp Gly  Tyr Gly Gly Ala Glu  Lys Ser Ala Arg Ser  Val Asp Glu 
    1145                 1150                 1155             


Ser Leu  Pro Phe Pro Gly Pro  His Val Leu Ile Cys  Asp Met Arg 
    1160                 1165                 1170             


Arg Xaa  Val 
    1175     


<210> 6846
<211> 1285
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (873)..(873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1187)..(1187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<400> 6846
Met Ala Leu Ala Arg Pro Gly Xaa Pro Asp Pro Gln Ala Leu Ala Ser 
1               5                   10                  15      


Val Leu Leu Leu Leu Leu Trp Ala Pro Ala Leu Ser Leu Leu Ala Gly 
            20                  25                  30          


Xaa Val Pro Ser Glu Pro Pro Ser Ala Cys Ala Ser Asp Pro Cys Ala 
        35                  40                  45              


Pro Gly Xaa Glu Cys Gln Ala Xaa Glu Ser Gly Gly Tyr Xaa Cys Gly 
    50                  55                  60                  


Pro Met Glu Pro Arg Gly Cys Ala Xaa Gln Pro Cys His His Gly Ala 
65                  70                  75                  80  


Leu Cys Val Pro Gln Gly Pro Asp Pro Xaa Gly Phe Arg Cys Tyr Cys 
                85                  90                  95      


Val Pro Gly Phe Gln Gly Pro Arg Cys Glu Leu Asp Ile Asp Glu Cys 
            100                 105                 110         


Ala Ser Arg Pro Cys His His Gly Ala Xaa Cys Arg Asn Leu Ala Asp 
        115                 120                 125             


Arg Tyr Glu Cys His Cys Pro Leu Gly Tyr Ala Gly Val Xaa Cys Glu 
    130                 135                 140                 


Met Glu Val Asp Glu Cys Ala Ser Ala Pro Cys Leu His Gly Gly Ser 
145                 150                 155                 160 


Cys Leu Asp Gly Val Gly Ser Phe Arg Cys Val Cys Ala Pro Gly Tyr 
                165                 170                 175     


Gly Gly Xaa Arg Cys Gln Leu Asp Leu Asp Glu Cys Gln Ser Gln Pro 
            180                 185                 190         


Cys Ala His Gly Gly Xaa Cys His Asp Leu Val Asn Gly Phe Arg Cys 
        195                 200                 205             


Asp Cys Ala Gly Xaa Gly Tyr Glu Gly Xaa His Cys Glu Arg Glu Val 
    210                 215                 220                 


Leu Glu Cys Ala Ser Ala Pro Cys Glu His Asn Ala Ser Cys Leu Glu 
225                 230                 235                 240 


Gly Leu Gly Ser Phe Arg Cys Leu Cys Trp Pro Gly Tyr Ser Gly Glu 
                245                 250                 255     


Leu Cys Glu Val Asp Glu Asp Glu Cys Ala Ser Ser Pro Cys Gln His 
            260                 265                 270         


Gly Gly Arg Cys Leu Gln Arg Ser Asp Pro Ala Leu Tyr Gly Gly Val 
        275                 280                 285             


Gln Ala Ala Phe Pro Gly Ala Phe Ser Phe Arg His Ala Ala Gly Phe 
    290                 295                 300                 


Leu Cys His Cys Pro Pro Gly Phe Glu Gly Ala Asp Cys Gly Val Glu 
305                 310                 315                 320 


Val Asp Glu Cys Ala Ser Arg Pro Cys Leu Asn Gly Gly His Cys Gln 
                325                 330                 335     


Asp Leu Pro Asn Gly Phe Gln Cys His Cys Pro Asp Gly Tyr Ala Gly 
            340                 345                 350         


Pro Xaa Cys Glu Glu Asp Val Asp Glu Cys Leu Ser Asp Pro Cys Leu 
        355                 360                 365             


His Gly Gly Xaa Cys Ser Asp Xaa Val Ala Gly Tyr Ile Cys Arg Cys 
    370                 375                 380                 


Pro Glu Xaa Trp Gly Gly Arg Asp Cys Ser Val Gln Leu Xaa Gly Cys 
385                 390                 395                 400 


Gln Gly His Xaa Cys Pro Leu Ala Ala Xaa Cys Ile Pro Ile Phe Glu 
                405                 410                 415     


Ser Gly Val His Ser Tyr Val Cys His Cys Pro Pro Gly Xaa His Gly 
            420                 425                 430         


Pro Phe Cys Gly Gln Asn Xaa Xaa Phe Ser Val Met Ala Gly Ser Pro 
        435                 440                 445             


Ile Gln Ala Ser Val Pro Ala Gly Gly Pro Leu Gly Leu Ala Leu Arg 
    450                 455                 460                 


Phe Arg Xaa Xaa Leu Pro Ala Gly Xaa Leu Ala Xaa Arg Asn Asp Xaa 
465                 470                 475                 480 


Lys Glu Ser Leu Glu Leu Ala Leu Val Ala Ala Xaa Leu Gln Ala Xaa 
                485                 490                 495     


Leu Trp Ser Tyr Ser Xaa Xaa Val Leu Val Leu Arg Leu Pro Asp Leu 
            500                 505                 510         


Ala Leu Asn Asp Gly His Trp His Gln Val Glu Val Val Leu His Leu 
        515                 520                 525             


Ala Xaa Leu Glu Leu Arg Leu Trp His Glu Gly Cys Pro Ala Arg Leu 
    530                 535                 540                 


Cys Val Ala Ser Gly Pro Val Ala Leu Ala Ser Xaa Ala Ser Ala Xaa 
545                 550                 555                 560 


Pro Leu Pro Ala Gly Ile Ser Ser Ala Gln Leu Gly Asp Ala Xaa Phe 
                565                 570                 575     


Ala Gly Cys Leu Gln Asp Val Arg Val Asp Gly His Leu Leu Leu Pro 
            580                 585                 590         


Glu Asp Leu Gly Glu Asn Val Leu Leu Gly Cys Glu Arg Arg Glu Gln 
        595                 600                 605             


Cys Arg Pro Leu Pro Cys Val His Gly Gly Ser Cys Val Asp Leu Trp 
    610                 615                 620                 


Xaa His Phe Arg Cys Asp Cys Ala Arg Pro His Arg Gly Pro Xaa Cys 
625                 630                 635                 640 


Ala Asp Glu Ile Pro Ala Ala Xaa Phe Gly Leu Gly Gly Ala Pro Ser 
                645                 650                 655     


Ser Ala Ser Phe Leu Leu Gln Glu Leu Pro Gly Pro Asn Leu Xaa Val 
            660                 665                 670         


Ser Phe Leu Leu Arg Xaa Arg Glu Ser Ala Gly Leu Leu Leu Gln Phe 
        675                 680                 685             


Ala Asn Asp Ser Ala Ala Gly Leu Xaa Val Phe Leu Ser Glu Gly Arg 
    690                 695                 700                 


Ile Arg Ala Glu Val Pro Gly Ser Pro Ala Val Val Leu Pro Gly Arg 
705                 710                 715                 720 


Trp Asp Asp Gly Leu Arg His Leu Val Met Leu Ser Phe Gly Pro Asp 
                725                 730                 735     


Gln Leu Gln Asp Leu Gly Gln His Val His Val Gly Gly Arg Leu Leu 
            740                 745                 750         


Ala Ala Asp Ser Gln Pro Trp Gly Gly Pro Phe Arg Gly Cys Leu Gln 
        755                 760                 765             


Asp Leu Arg Leu Asp Gly Cys His Leu Pro Phe Phe Pro Leu Pro Leu 
    770                 775                 780                 


Asp Asn Ser Ser Gln Pro Ser Glu Leu Gly Gly Arg Gln Ser Trp Asn 
785                 790                 795                 800 


Leu Xaa Ala Gly Cys Val Ser Glu Asp Met Cys Ser Pro Asp Pro Cys 
                805                 810                 815     


Phe Asn Gly Gly Xaa Cys Leu Val Xaa Trp Asn Asp Phe His Cys Xaa 
            820                 825                 830         


Cys Pro Ala Asn Phe Xaa Gly Pro Xaa Cys Ala Gln Gln Leu Trp Cys 
        835                 840                 845             


Pro Gly Gln Pro Cys Leu Pro Pro Ala Xaa Cys Glu Glu Val Pro Asp 
    850                 855                 860                 


Gly Phe Val Cys Val Ala Glu Ala Xaa Phe Arg Glu Gly Pro Pro Ala 
865                 870                 875                 880 


Ala Phe Ser Gly His Asn Ala Ser Ser Gly Arg Leu Leu Gly Gly Leu 
                885                 890                 895     


Ser Leu Ala Phe Arg Xaa Arg Asp Ser Glu Ala Trp Leu Leu Arg Ala 
            900                 905                 910         


Ala Ala Gly Ala Leu Glu Gly Val Trp Leu Ala Val Arg Asn Gly Ser 
        915                 920                 925             


Leu Ala Gly Gly Val Arg Gly Gly His Gly Leu Pro Gly Ala Val Leu 
    930                 935                 940                 


Pro Ile Pro Gly Pro Arg Val Ala Asp Gly Ala Trp His Arg Val Arg 
945                 950                 955                 960 


Leu Ala Met Glu Arg Pro Ala Ala Xaa Xaa Ser Arg Trp Leu Leu Trp 
                965                 970                 975     


Leu Asp Gly Ala Ala Xaa Pro Val Ala Leu Arg Gly Leu Ala Ser Asp 
            980                 985                 990         


Leu Gly Phe Leu Gln Gly Pro Gly  Ala Val Arg Ile Leu  Leu Ala Glu 
        995                 1000                 1005             


Asn Phe  Xaa Gly Cys Leu Gly  Arg Val Ala Leu Gly  Gly Leu Pro 
    1010                 1015                 1020             


Leu Pro  Leu Ala Arg Pro Arg  Pro Gly Ala Ala Pro  Gly Ala Arg 
    1025                 1030                 1035             


Glu His  Phe Ala Ser Trp Pro  Gly Xaa Pro Ala Pro  Ile Leu Gly 
    1040                 1045                 1050             


Cys Arg  Gly Ala Pro Val Cys  Ala Pro Ser Pro Cys  Leu His Asp 
    1055                 1060                 1065             


Gly Ala  Cys Arg Asp Leu Phe  Asp Ala Phe Ala Cys  Ala Cys Gly 
    1070                 1075                 1080             


Pro Gly  Trp Glu Gly Pro Arg  Cys Glu Ala His Val  Asp Pro Cys 
    1085                 1090                 1095             


His Ser  Ala Pro Cys Ala Arg  Gly Arg Cys His Xaa  His Pro Asp 
    1100                 1105                 1110             


Gly Arg  Phe Glu Cys Arg Cys  Pro Pro Gly Phe Gly  Gly Pro Arg 
    1115                 1120                 1125             


Cys Arg  Leu Pro Val Pro Ser  Lys Glu Cys Ser Leu  Asn Val Xaa 
    1130                 1135                 1140             


Cys Leu  Asp Gly Ser Pro Cys  Glu Gly Gly Ser Pro  Ala Ala Asn 
    1145                 1150                 1155             


Cys Ser  Cys Leu Glu Gly Leu  Ala Gly Gln Arg Cys  Gln Val Pro 
    1160                 1165                 1170             


Xaa Leu  Pro Cys Glu Ala Asn  Pro Cys Leu Asn Gly  Gly Xaa Cys 
    1175                 1180                 1185             


Arg Ala  Ala Gly Gly Val Ser  Glu Cys Ile Cys Asn  Ala Arg Phe 
    1190                 1195                 1200             


Ser Gly  Gln Phe Cys Glu Val  Ala Lys Gly Leu Pro  Leu Pro Leu 
    1205                 1210                 1215             


Pro Phe  Pro Leu Leu Glu Val  Ala Val Pro Ala Ala  Cys Ala Cys 
    1220                 1225                 1230             


Leu Leu  Leu Leu Leu Leu Gly  Leu Leu Ser Gly Ile  Leu Ala Ala 
    1235                 1240                 1245             


Arg Lys  Arg Arg Gln Ser Glu  Gly Xaa Tyr Ser Pro  Ser Gln Gln 
    1250                 1255                 1260             


Glu Val  Ala Gly Ala Arg Leu  Glu Met Asp Ser Val  Leu Lys Val 
    1265                 1270                 1275             


Pro Pro  Glu Glu Arg Leu Ile  
    1280                 1285 


<210> 6847
<211> 953
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(925)
<223> Selenocysteine

<400> 6847
Met Ala Met Glu Pro Gly Ala Leu Trp Xaa Phe Leu Gly His Leu Trp 
1               5                   10                  15      


Leu Leu Ala Gly Pro Xaa Cys Glu Glu Asp Val Asp Glu Cys Leu Ser 
            20                  25                  30          


Asp Pro Cys Leu His Gly Gly Xaa Cys Ser Asp Xaa Val Ala Gly Tyr 
        35                  40                  45              


Ile Cys Arg Cys Pro Glu Xaa Trp Gly Gly Arg Asp Cys Ser Val Gln 
    50                  55                  60                  


Leu Xaa Gly Cys Gln Gly His Xaa Cys Pro Leu Ala Ala Xaa Cys Ile 
65                  70                  75                  80  


Pro Ile Phe Glu Ser Gly Val His Ser Tyr Val Cys His Cys Pro Pro 
                85                  90                  95      


Gly Xaa His Gly Pro Phe Cys Gly Gln Asn Xaa Xaa Phe Ser Val Met 
            100                 105                 110         


Ala Gly Ser Pro Ile Gln Ala Ser Val Pro Ala Gly Gly Pro Leu Gly 
        115                 120                 125             


Leu Ala Leu Arg Phe Arg Xaa Xaa Leu Pro Ala Gly Xaa Leu Ala Xaa 
    130                 135                 140                 


Arg Asn Asp Xaa Lys Glu Ser Leu Glu Leu Ala Leu Val Ala Ala Xaa 
145                 150                 155                 160 


Leu Gln Ala Xaa Leu Trp Ser Tyr Ser Xaa Xaa Val Leu Val Leu Arg 
                165                 170                 175     


Leu Pro Asp Leu Ala Leu Asn Asp Gly His Trp His Gln Val Glu Val 
            180                 185                 190         


Val Leu His Leu Ala Xaa Leu Glu Leu Arg Leu Trp His Glu Gly Cys 
        195                 200                 205             


Pro Ala Arg Leu Cys Val Ala Ser Gly Pro Val Ala Leu Ala Ser Xaa 
    210                 215                 220                 


Ala Ser Ala Xaa Pro Leu Pro Ala Gly Ile Ser Ser Ala Gln Leu Gly 
225                 230                 235                 240 


Asp Ala Xaa Phe Ala Gly Cys Leu Gln Asp Val Arg Val Asp Gly His 
                245                 250                 255     


Leu Leu Leu Pro Glu Asp Leu Gly Glu Asn Val Leu Leu Gly Cys Glu 
            260                 265                 270         


Arg Arg Glu Gln Cys Arg Pro Leu Pro Cys Val His Gly Gly Ser Cys 
        275                 280                 285             


Val Asp Leu Trp Xaa His Phe Arg Cys Asp Cys Ala Arg Pro His Arg 
    290                 295                 300                 


Gly Pro Xaa Cys Ala Asp Glu Ile Pro Ala Ala Xaa Phe Gly Leu Gly 
305                 310                 315                 320 


Gly Ala Pro Ser Ser Ala Ser Phe Leu Leu Gln Glu Leu Pro Gly Pro 
                325                 330                 335     


Asn Leu Xaa Val Ser Phe Leu Leu Arg Xaa Arg Glu Ser Ala Gly Leu 
            340                 345                 350         


Leu Leu Gln Phe Ala Asn Asp Ser Ala Ala Gly Leu Xaa Val Phe Leu 
        355                 360                 365             


Ser Glu Gly Arg Ile Arg Ala Glu Val Pro Gly Ser Pro Ala Val Val 
    370                 375                 380                 


Leu Pro Gly Arg Trp Asp Asp Gly Leu Arg His Leu Val Met Leu Ser 
385                 390                 395                 400 


Phe Gly Pro Asp Gln Leu Gln Asp Leu Gly Gln His Val His Val Gly 
                405                 410                 415     


Gly Arg Leu Leu Ala Ala Asp Ser Gln Pro Trp Gly Gly Pro Phe Arg 
            420                 425                 430         


Gly Cys Leu Gln Asp Leu Arg Leu Asp Gly Cys His Leu Pro Phe Phe 
        435                 440                 445             


Pro Leu Pro Leu Asp Asn Ser Ser Gln Pro Ser Glu Leu Gly Gly Arg 
    450                 455                 460                 


Gln Ser Trp Asn Leu Xaa Ala Gly Cys Val Ser Glu Asp Met Cys Ser 
465                 470                 475                 480 


Pro Asp Pro Cys Phe Asn Gly Gly Xaa Cys Leu Val Xaa Trp Asn Asp 
                485                 490                 495     


Phe His Cys Xaa Cys Pro Ala Asn Phe Xaa Gly Pro Xaa Cys Ala Gln 
            500                 505                 510         


Gln Leu Trp Cys Pro Gly Gln Pro Cys Leu Pro Pro Ala Xaa Cys Glu 
        515                 520                 525             


Glu Val Pro Asp Gly Phe Val Cys Val Ala Glu Ala Xaa Phe Arg Glu 
    530                 535                 540                 


Gly Pro Pro Ala Ala Phe Ser Gly His Asn Ala Ser Ser Gly Arg Leu 
545                 550                 555                 560 


Leu Gly Gly Leu Ser Leu Ala Phe Arg Xaa Arg Asp Ser Glu Ala Trp 
                565                 570                 575     


Leu Leu Arg Ala Ala Ala Gly Ala Leu Glu Gly Val Trp Leu Ala Val 
            580                 585                 590         


Arg Asn Gly Ser Leu Ala Gly Gly Val Arg Gly Gly His Gly Leu Pro 
        595                 600                 605             


Gly Ala Val Leu Pro Ile Pro Gly Pro Arg Val Ala Asp Gly Ala Trp 
    610                 615                 620                 


His Arg Val Arg Leu Ala Met Glu Arg Pro Ala Ala Xaa Xaa Ser Arg 
625                 630                 635                 640 


Trp Leu Leu Trp Leu Asp Gly Ala Ala Xaa Pro Val Ala Leu Arg Gly 
                645                 650                 655     


Leu Ala Ser Asp Leu Gly Phe Leu Gln Gly Pro Gly Ala Val Arg Ile 
            660                 665                 670         


Leu Leu Ala Glu Asn Phe Xaa Gly Cys Leu Gly Arg Val Ala Leu Gly 
        675                 680                 685             


Gly Leu Pro Leu Pro Leu Ala Arg Pro Arg Pro Gly Ala Ala Pro Gly 
    690                 695                 700                 


Ala Arg Glu His Phe Ala Ser Trp Pro Gly Xaa Pro Ala Pro Ile Leu 
705                 710                 715                 720 


Gly Cys Arg Gly Ala Pro Val Cys Ala Pro Ser Pro Cys Leu His Asp 
                725                 730                 735     


Gly Ala Cys Arg Asp Leu Phe Asp Ala Phe Ala Cys Ala Cys Gly Pro 
            740                 745                 750         


Gly Trp Glu Gly Pro Arg Cys Glu Ala His Val Asp Pro Cys His Ser 
        755                 760                 765             


Ala Pro Cys Ala Arg Gly Arg Cys His Xaa His Pro Asp Gly Arg Phe 
    770                 775                 780                 


Glu Cys Arg Cys Pro Pro Gly Phe Gly Gly Pro Arg Cys Arg Leu Pro 
785                 790                 795                 800 


Val Pro Ser Lys Glu Cys Ser Leu Asn Val Xaa Cys Leu Asp Gly Ser 
                805                 810                 815     


Pro Cys Glu Gly Gly Ser Pro Ala Ala Asn Cys Ser Cys Leu Glu Gly 
            820                 825                 830         


Leu Ala Gly Gln Arg Cys Gln Val Pro Xaa Leu Pro Cys Glu Ala Asn 
        835                 840                 845             


Pro Cys Leu Asn Gly Gly Xaa Cys Arg Ala Ala Gly Gly Val Ser Glu 
    850                 855                 860                 


Cys Ile Cys Asn Ala Arg Phe Ser Gly Gln Phe Cys Glu Val Ala Lys 
865                 870                 875                 880 


Gly Leu Pro Leu Pro Leu Pro Phe Pro Leu Leu Glu Val Ala Val Pro 
                885                 890                 895     


Ala Ala Cys Ala Cys Leu Leu Leu Leu Leu Leu Gly Leu Leu Ser Gly 
            900                 905                 910         


Ile Leu Ala Ala Arg Lys Arg Arg Gln Ser Glu Gly Xaa Tyr Ser Pro 
        915                 920                 925             


Ser Gln Gln Glu Val Ala Gly Ala Arg Leu Glu Met Asp Ser Val Leu 
    930                 935                 940                 


Lys Val Pro Pro Glu Glu Arg Leu Ile 
945                 950             


<210> 6848
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<400> 6848
Met Glu Val Ala Glu Lys Leu Gln Leu Leu Asn His Arg Pro Val Xaa 
1               5                   10                  15      


Ala Val Glu Ile Gln Leu Met Val Glu Glu Ser Glu Glu Arg Leu Xaa 
            20                  25                  30          


Glu Glu Gln Ile Glu Ala Leu Leu His Xaa Val Xaa Ser Ile Leu Pro 
        35                  40                  45              


Ala Glu Pro Glu Ala Glu Gln Lys Lys Asn Xaa Asn Ser Asn Val Ala 
    50                  55                  60                  


Met Asp Glu Glu Asp Pro Ala 
65                  70      


<210> 6849
<211> 42
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<400> 6849
Met Glu Val Lys Asp Ala Asn Ser Ala Leu Leu Ser Asn Tyr Glu Met 
1               5                   10                  15      


Glu Ser Arg Ser Val Xaa Gln Ala Gly Val Gln Trp His His Pro Gly 
            20                  25                  30          


Ser Leu Gln Pro Leu Pro Pro Gly Phe Lys 
        35                  40          


<210> 6850
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 6850
Met Glu Val Lys Asp Ala Asn Ser Ala Leu Leu Ser Asn Tyr Glu Xaa 
1               5                   10                  15      


Leu Lys Tyr Ile Ser Lys Xaa Pro Cys Arg His Gln Ser Pro Glu Ile 
            20                  25                  30          


Val Arg Glu Phe Leu Xaa Ala Leu Lys Ser His Lys Leu Xaa Lys Ala 
        35                  40                  45              


Glu Lys Leu Gln Leu Leu Asn His Arg Pro Val Xaa Ala Val Glu Ile 
    50                  55                  60                  


Gln Leu Met Val Glu Glu Ser Glu Glu Arg Leu Xaa Glu Glu Gln Ile 
65                  70                  75                  80  


Glu Ala Leu Leu His Xaa Val Xaa Ser Ile Leu Pro Ala Glu Pro Glu 
                85                  90                  95      


Ala Glu Gln Lys Lys Asn Xaa Asn Ser Asn Val Ala Met Asp Glu Glu 
            100                 105                 110         


Asp Pro Ala 
        115 


<210> 6851
<211> 148
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 6851
Met Glu Val Lys Asp Ala Asn Ser Ala Leu Leu Ser Asn Tyr Glu Val 
1               5                   10                  15      


Phe Gln Leu Leu Xaa Asp Leu Lys Glu Gln Arg Lys Glu Ser Gly Lys 
            20                  25                  30          


Asn Lys His Ser Ser Gly Gln Gln Asn Leu Asn Xaa Ile Xaa Tyr Glu 
        35                  40                  45              


Xaa Leu Lys Tyr Ile Ser Lys Xaa Pro Cys Arg His Gln Ser Pro Glu 
    50                  55                  60                  


Ile Val Arg Glu Phe Leu Xaa Ala Leu Lys Ser His Lys Leu Xaa Lys 
65                  70                  75                  80  


Ala Glu Lys Leu Gln Leu Leu Asn His Arg Pro Val Xaa Ala Val Glu 
                85                  90                  95      


Ile Gln Leu Met Val Glu Glu Ser Glu Glu Arg Leu Xaa Glu Glu Gln 
            100                 105                 110         


Ile Glu Ala Leu Leu His Xaa Val Xaa Ser Ile Leu Pro Ala Glu Pro 
        115                 120                 125             


Glu Ala Glu Gln Lys Lys Asn Xaa Asn Ser Asn Val Ala Met Asp Glu 
    130                 135                 140                 


Glu Asp Pro Ala 
145             


<210> 6852
<211> 141
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 6852
Met Gln Arg Gly Asp Pro Gly Glu His Leu Gly Ala Arg Ser Trp His 
1               5                   10                  15      


Leu Gly Ala Val Gly Gly Gly Gly Asp Ser Cys Glu Val Lys Asp Ala 
            20                  25                  30          


Asn Ser Ala Leu Leu Ser Asn Tyr Glu Xaa Leu Lys Tyr Ile Ser Lys 
        35                  40                  45              


Xaa Pro Cys Arg His Gln Ser Pro Glu Ile Val Arg Glu Phe Leu Xaa 
    50                  55                  60                  


Ala Leu Lys Ser His Lys Leu Xaa Lys Ala Glu Lys Leu Gln Leu Leu 
65                  70                  75                  80  


Asn His Arg Pro Val Xaa Ala Val Glu Ile Gln Leu Met Val Glu Glu 
                85                  90                  95      


Ser Glu Glu Arg Leu Xaa Glu Glu Gln Ile Glu Ala Leu Leu His Xaa 
            100                 105                 110         


Val Xaa Ser Ile Leu Pro Ala Glu Pro Glu Ala Glu Gln Lys Lys Asn 
        115                 120                 125             


Xaa Asn Ser Asn Val Ala Met Asp Glu Glu Asp Pro Ala 
    130                 135                 140     


<210> 6853
<211> 140
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 6853
Gly Gly Ala Ile Gln Leu Ala Asn Asn Gly Xaa Asp Gly Val Gln Gly 
1               5                   10                  15      


Leu Gln Xaa Leu Xaa Met Xaa Asn Ala Ala Ala Xaa Gln Pro Gly Xaa 
            20                  25                  30          


Xaa Ile Leu Gln Tyr Ala Gln Xaa Xaa Asp Gly Gln Gln Ile Leu Val 
        35                  40                  45              


Pro Ser Asn Gln Val Val Val Gln Ala Ala Ser Gly Asp Val Gln Xaa 
    50                  55                  60                  


Tyr Gln Ile Arg Xaa Ala Pro Xaa Ser Xaa Ile Ala Pro Gly Val Val 
65                  70                  75                  80  


Met Ala Ser Ser Pro Ala Leu Pro Xaa Gln Pro Ala Glu Glu Ala Ala 
                85                  90                  95      


Arg Lys Arg Glu Val Arg Leu Met Lys Asn Arg Tyr Lys Tyr Cys Ile 
            100                 105                 110         


Tyr Leu Asp Cys Tyr Val Leu Ser Val Ser Ser His Ser Ala Gly Cys 
        115                 120                 125             


Val Ser Leu His Leu Leu Val Ile Gly Ser Leu His 
    130                 135                 140 


<210> 6854
<211> 251
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<400> 6854
Met Pro Ala Ala His Ala Xaa Ser Ser Ala Pro Xaa Val Xaa Leu Val 
1               5                   10                  15      


Gln Leu Pro Asn Gly Gln Xaa Val Gln Val His Gly Val Ile Gln Ala 
            20                  25                  30          


Ala Gln Pro Ser Val Ile Gln Ser Pro Gln Val Gln Xaa Val Gln Ile 
        35                  40                  45              


Ser Xaa Ile Ala Glu Ser Glu Asp Ser Gln Glu Ser Val Asp Ser Val 
    50                  55                  60                  


Xaa Asp Ser Gln Lys Arg Arg Glu Ile Leu Ser Arg Arg Pro Ser Tyr 
65                  70                  75                  80  


Arg Lys Ile Leu Asn Asp Leu Ser Ser Asp Ala Pro Gly Val Pro Arg 
                85                  90                  95      


Ile Glu Glu Glu Lys Ser Glu Glu Glu Xaa Ser Ala Pro Ala Ile Xaa 
            100                 105                 110         


Xaa Val Xaa Val Pro Xaa Pro Ile Tyr Gln Xaa Ser Ser Gly Gln Tyr 
        115                 120                 125             


Ile Ala Ile Xaa Gln Gly Gly Ala Ile Gln Leu Ala Asn Asn Gly Xaa 
    130                 135                 140                 


Asp Gly Val Gln Gly Leu Gln Xaa Leu Xaa Met Xaa Asn Ala Ala Ala 
145                 150                 155                 160 


Xaa Gln Pro Gly Xaa Xaa Ile Leu Gln Tyr Ala Gln Xaa Xaa Asp Gly 
                165                 170                 175     


Gln Gln Ile Leu Val Pro Ser Asn Gln Val Val Val Gln Ala Ala Ser 
            180                 185                 190         


Gly Asp Val Gln Xaa Tyr Gln Ile Arg Xaa Ala Pro Xaa Ser Xaa Ile 
        195                 200                 205             


Ala Pro Gly Val Val Met Ala Ser Ser Pro Ala Leu Pro Xaa Gln Pro 
    210                 215                 220                 


Ala Glu Glu Ala Ala Arg Lys Arg Glu Val Arg Leu Met Lys Asn Arg 
225                 230                 235                 240 


Glu Ala Ala Arg Glu Cys Arg Arg Lys Lys Lys 
                245                 250     


<210> 6855
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<400> 6855
Met Pro Ala Ala His Ala Xaa Ser Ser Ala Pro Xaa Val Xaa Leu Val 
1               5                   10                  15      


Gln Leu Pro Asn Gly Gln Xaa Val Gln Val His Gly Val Ile Gln Ala 
            20                  25                  30          


Ala Gln Pro Ser Val Ile Gln Ser Pro Gln Val Gln Xaa Val Gln Ile 
        35                  40                  45              


Ser Xaa Ile Ala Glu Ser Glu Asp Ser Gln Glu Ser Val Asp Ser Val 
    50                  55                  60                  


Xaa Asp Ser Gln Lys Arg Arg Glu Ile Leu Ser Arg Arg Pro Ser Tyr 
65                  70                  75                  80  


Arg Lys Ile Leu Asn Asp Leu Ser Ser Asp Ala Pro Gly Val Pro Arg 
                85                  90                  95      


Ile Glu Glu Glu Lys Ser Glu Glu Glu Xaa Ser Ala Pro Ala Ile Xaa 
            100                 105                 110         


Xaa Val Xaa Val Pro Xaa Pro Ile Tyr Gln Xaa Ser Ser Gly Gln Tyr 
        115                 120                 125             


Xaa Ala Ser Gly Asp Val Gln Xaa Tyr Gln Ile Arg Xaa Ala Pro Xaa 
    130                 135                 140                 


Ser Xaa Ile Ala Pro Gly Val Val Met Ala Ser Ser Pro Ala Leu Pro 
145                 150                 155                 160 


Xaa Gln Pro Ala Glu Glu Ala Ala Arg Lys 
                165                 170 


<210> 6856
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<400> 6856
Met Pro Ala Ala His Ala Xaa Ser Ser Ala Pro Xaa Val Xaa Leu Val 
1               5                   10                  15      


Gln Leu Pro Asn Gly Gln Xaa Val Gln Val His Gly Val Ile Gln Ala 
            20                  25                  30          


Ala Gln Pro Ser Val Ile Gln Ser Pro Gln Val Gln Xaa Val Gln Ser 
        35                  40                  45              


Ser Cys Lys Asp Leu Lys Arg Leu Phe Ser Gly Xaa Gln Ile Ser Xaa 
    50                  55                  60                  


Ile Ala Glu Ser Glu Asp Ser Gln Glu Ser Val Asp Ser Val Xaa Asp 
65                  70                  75                  80  


Ser Gln Lys Arg Arg Glu Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys 
                85                  90                  95      


Ile Leu Asn Asp Leu Ser Ser Asp Ala Pro Gly Val Pro Arg Ile Glu 
            100                 105                 110         


Glu Glu Lys Ser Glu Glu Glu Xaa Ser Ala Pro Ala Ile Xaa Xaa Val 
        115                 120                 125             


Xaa Val Pro 
    130     


<210> 6857
<211> 79
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<400> 6857
Met Xaa Met Glu Ser Gly Ala Glu Asn Gln Gln Ser Gly Asp Ala Ala 
1               5                   10                  15      


Val Xaa Glu Ala Glu Asn Gln Gln Met Xaa Val Gln Ala Gln Pro Gln 
            20                  25                  30          


Ile Ala Xaa Leu Ala Gln Val Ser Met Pro Ala Ala His Ala Xaa Ser 
        35                  40                  45              


Ser Ala Pro Xaa Val Xaa Leu Val Gln Leu Pro Asn Gly Gln Xaa Val 
    50                  55                  60                  


Gln Val His Gly Val Ile Gln Ala Ala Gln Pro Ser Val Ile Gln 
65                  70                  75                  


<210> 6858
<211> 327
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<400> 6858
Met Xaa Met Glu Ser Gly Ala Glu Asn Gln Gln Ser Gly Asp Ala Ala 
1               5                   10                  15      


Val Xaa Glu Ala Glu Asn Gln Gln Met Xaa Val Gln Ala Gln Pro Gln 
            20                  25                  30          


Ile Ala Xaa Leu Ala Gln Val Ser Met Pro Ala Ala His Ala Xaa Ser 
        35                  40                  45              


Ser Ala Pro Xaa Val Xaa Leu Val Gln Leu Pro Asn Gly Gln Xaa Val 
    50                  55                  60                  


Gln Val His Gly Val Ile Gln Ala Ala Gln Pro Ser Val Ile Gln Ser 
65                  70                  75                  80  


Pro Gln Val Gln Xaa Val Gln Ile Ser Xaa Ile Ala Glu Ser Glu Asp 
                85                  90                  95      


Ser Gln Glu Ser Val Asp Ser Val Xaa Asp Ser Gln Lys Arg Arg Glu 
            100                 105                 110         


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Asp Leu Ser 
        115                 120                 125             


Ser Asp Ala Pro Gly Val Pro Arg Ile Glu Glu Glu Lys Ser Glu Glu 
    130                 135                 140                 


Glu Xaa Ser Ala Pro Ala Ile Xaa Xaa Val Xaa Val Pro Xaa Pro Ile 
145                 150                 155                 160 


Tyr Gln Xaa Ser Ser Gly Gln Tyr Ile Ala Ile Xaa Gln Gly Gly Ala 
                165                 170                 175     


Ile Gln Leu Ala Asn Asn Gly Xaa Asp Gly Val Gln Gly Leu Gln Xaa 
            180                 185                 190         


Leu Xaa Met Xaa Asn Ala Ala Ala Xaa Gln Pro Gly Xaa Xaa Ile Leu 
        195                 200                 205             


Gln Tyr Ala Gln Xaa Xaa Asp Gly Gln Gln Ile Leu Val Pro Ser Asn 
    210                 215                 220                 


Gln Val Val Val Gln Ala Ala Ser Gly Asp Val Gln Xaa Tyr Gln Ile 
225                 230                 235                 240 


Arg Xaa Ala Pro Xaa Ser Xaa Ile Ala Pro Gly Val Val Met Ala Ser 
                245                 250                 255     


Ser Pro Ala Leu Pro Xaa Gln Pro Ala Glu Glu Ala Ala Arg Lys Arg 
            260                 265                 270         


Glu Val Arg Leu Met Lys Asn Arg Glu Ala Ala Arg Glu Cys Arg Arg 
        275                 280                 285             


Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn Arg Val Ala Val Leu 
    290                 295                 300                 


Glu Asn Gln Asn Lys Xaa Leu Ile Glu Glu Leu Lys Ala Leu Lys Asp 
305                 310                 315                 320 


Leu Tyr Cys His Lys Ser Asp 
                325         


<210> 6859
<211> 132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<400> 6859
Met Xaa Met Glu Ser Gly Ala Glu Asn Gln Gln Ser Gly Asp Ala Ala 
1               5                   10                  15      


Val Xaa Glu Ala Glu Asn Gln Gln Met Xaa Val Gln Ala Gln Pro Gln 
            20                  25                  30          


Ile Ala Xaa Leu Ala Gln Val Ser Met Pro Ala Ala His Ala Xaa Ser 
        35                  40                  45              


Ser Ala Pro Xaa Val Xaa Leu Val Gln Leu Pro Asn Gly Gln Xaa Val 
    50                  55                  60                  


Gln Val His Gly Val Ile Gln Ala Ala Gln Pro Ser Val Ile Gln Ser 
65                  70                  75                  80  


Pro Gln Val Gln Xaa Val Gln Ser Ser Cys Lys Asp Leu Lys Arg Leu 
                85                  90                  95      


Phe Ser Gly Xaa Gln Ile Ser Xaa Ile Ala Glu Ser Glu Asp Ser Gln 
            100                 105                 110         


Glu Ser Val Asp Ser Val Xaa Asp Ser Gln Lys Arg Arg Glu Ile Leu 
        115                 120                 125             


Ser Arg Arg Pro 
    130         


<210> 6860
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<400> 6860
Met Xaa Met Glu Ser Gly Ala Glu Asn Gln Gln Ser Gly Asp Ala Ala 
1               5                   10                  15      


Val Xaa Glu Ala Glu Asn Gln Gln Met Xaa Val Gln Ala Gln Pro Gln 
            20                  25                  30          


Ile Ala Xaa Leu Ala Gln Val Ser Met Pro Ala Ala His Ala Xaa Ser 
        35                  40                  45              


Ser Ala Pro Xaa Val Xaa Leu Val Gln Leu Pro Asn Gly Gln Xaa Val 
    50                  55                  60                  


Gln Val His Gly Val Ile Gln Ala Ala Gln Pro Ser Val Ile Gln Ser 
65                  70                  75                  80  


Pro Gln Val Gln Xaa Val Gln Ser Ser Cys Lys Asp Leu Lys Arg Leu 
                85                  90                  95      


Phe Ser Gly Xaa Gln Ile Ser Xaa Ile Ala Glu Ser Glu Asp Ser Gln 
            100                 105                 110         


Glu Ser Val Asp Ser Val Xaa Asp Ser Gln Lys Arg Arg Glu Ile Leu 
        115                 120                 125             


Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Asp Leu Ser Ser Asp 
    130                 135                 140                 


Ala Pro Gly Val Pro Arg Ile Glu Glu Glu Lys Ser Glu Glu Glu Xaa 
145                 150                 155                 160 


Ser Ala Pro Ala Ile Xaa Xaa Val Xaa Val Pro Xaa Pro Ile Tyr Gln 
                165                 170                 175     


Xaa Ser Ser Gly Gln Tyr 
            180         


<210> 6861
<211> 341
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<400> 6861
Met Xaa Met Glu Ser Gly Ala Glu Asn Gln Gln Ser Gly Asp Ala Ala 
1               5                   10                  15      


Val Xaa Glu Ala Glu Asn Gln Gln Met Xaa Val Gln Ala Gln Pro Gln 
            20                  25                  30          


Ile Ala Xaa Leu Ala Gln Val Ser Met Pro Ala Ala His Ala Xaa Ser 
        35                  40                  45              


Ser Ala Pro Xaa Val Xaa Leu Val Gln Leu Pro Asn Gly Gln Xaa Val 
    50                  55                  60                  


Gln Val His Gly Val Ile Gln Ala Ala Gln Pro Ser Val Ile Gln Ser 
65                  70                  75                  80  


Pro Gln Val Gln Xaa Val Gln Ser Ser Cys Lys Asp Leu Lys Arg Leu 
                85                  90                  95      


Phe Ser Gly Xaa Gln Ile Ser Xaa Ile Ala Glu Ser Glu Asp Ser Gln 
            100                 105                 110         


Glu Ser Val Asp Ser Val Xaa Asp Ser Gln Lys Arg Arg Glu Ile Leu 
        115                 120                 125             


Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Asp Leu Ser Ser Asp 
    130                 135                 140                 


Ala Pro Gly Val Pro Arg Ile Glu Glu Glu Lys Ser Glu Glu Glu Xaa 
145                 150                 155                 160 


Ser Ala Pro Ala Ile Xaa Xaa Val Xaa Val Pro Xaa Pro Ile Tyr Gln 
                165                 170                 175     


Xaa Ser Ser Gly Gln Tyr Ile Ala Ile Xaa Gln Gly Gly Ala Ile Gln 
            180                 185                 190         


Leu Ala Asn Asn Gly Xaa Asp Gly Val Gln Gly Leu Gln Xaa Leu Xaa 
        195                 200                 205             


Met Xaa Asn Ala Ala Ala Xaa Gln Pro Gly Xaa Xaa Ile Leu Gln Tyr 
    210                 215                 220                 


Ala Gln Xaa Xaa Asp Gly Gln Gln Ile Leu Val Pro Ser Asn Gln Val 
225                 230                 235                 240 


Val Val Gln Ala Ala Ser Gly Asp Val Gln Xaa Tyr Gln Ile Arg Xaa 
                245                 250                 255     


Ala Pro Xaa Ser Xaa Ile Ala Pro Gly Val Val Met Ala Ser Ser Pro 
            260                 265                 270         


Ala Leu Pro Xaa Gln Pro Ala Glu Glu Ala Ala Arg Lys Arg Glu Val 
        275                 280                 285             


Arg Leu Met Lys Asn Arg Glu Ala Ala Arg Glu Cys Arg Arg Lys Lys 
    290                 295                 300                 


Lys Glu Tyr Val Lys Cys Leu Glu Asn Arg Val Ala Val Leu Glu Asn 
305                 310                 315                 320 


Gln Asn Lys Xaa Leu Ile Glu Glu Leu Lys Ala Leu Lys Asp Leu Tyr 
                325                 330                 335     


Cys His Lys Ser Asp 
            340     


<210> 6862
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<400> 6862
Xaa Val Ile Gln Ala Ala Gln Pro Ser Val Ile Gln Ser Pro Gln Val 
1               5                   10                  15      


Gln Xaa Val Gln Ser Ser Cys Lys Asp Leu Lys Arg Leu Phe Ser Gly 
            20                  25                  30          


Xaa Gln Ile Ser Xaa Ile Ala Glu Ser Glu Asp Ser Gln Glu Ser Val 
        35                  40                  45              


Asp Ser Val Xaa Asp Ser Gln Lys Arg Arg Glu Ile Leu Ser Arg Arg 
    50                  55                  60                  


Pro Ser Tyr Arg Lys Ile Leu Asn Asp Leu Ser Ser Asp Ala Pro Gly 
65                  70                  75                  80  


Val Pro Arg Ile Glu Glu Glu Lys Ser Glu Glu Glu Xaa Ser Ala Pro 
                85                  90                  95      


Ala Ile Xaa Xaa Val Xaa Val Pro Xaa Pro Ile Tyr Gln Xaa Ser Ser 
            100                 105                 110         


Gly Gln Tyr Ile Ala Ile Xaa Gln Gly Gly Ala Ile Gln Leu Ala Asn 
        115                 120                 125             


Asn Gly Xaa Asp Gly Val Gln Gly Leu Gln Xaa Leu Xaa Met Xaa Asn 
    130                 135                 140                 


Ala Ala Ala Xaa Gln Pro Gly Xaa Xaa Ile Leu Gln Tyr Ala Gln Xaa 
145                 150                 155                 160 


Xaa Asp Gly Gln Gln Ile Leu Val Pro Ser Asn Gln Val Val Val Gln 
                165                 170                 175     


Gly Xaa Gln Lys Leu 
            180     


<210> 6863
<211> 371
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<400> 6863
Met Glu Leu Glu Leu Asp Ala Gly Asp Gln Asp Leu Leu Ala Phe Leu 
1               5                   10                  15      


Leu Glu Glu Ser Gly Asp Leu Gly Xaa Ala Pro Asp Glu Ala Val Arg 
            20                  25                  30          


Ala Pro Leu Asp Trp Ala Leu Pro Leu Ser Glu Val Pro Ser Asp Trp 
        35                  40                  45              


Glu Val Asp Asp Leu Leu Cys Ser Leu Leu Ser Pro Pro Ala Ser Leu 
    50                  55                  60                  


Asn Ile Leu Ser Ser Ser Asn Pro Cys Leu Val His His Asp His Xaa 
65                  70                  75                  80  


Tyr Ser Leu Pro Arg Glu Xaa Val Ser Met Asp Leu Glu Ser Glu Ser 
                85                  90                  95      


Cys Arg Lys Glu Gly Xaa Gln Met Xaa Pro Gln His Met Glu Glu Leu 
            100                 105                 110         


Ala Glu Gln Glu Ile Ala Arg Leu Val Leu Xaa Asp Glu Glu Lys Ser 
        115                 120                 125             


Leu Leu Glu Lys Glu Gly Leu Ile Leu Pro Glu Xaa Leu Pro Leu Xaa 
    130                 135                 140                 


Lys Xaa Glu Glu Gln Ile Leu Lys Arg Val Arg Arg Lys Ile Arg Asn 
145                 150                 155                 160 


Lys Arg Ser Ala Gln Glu Ser Arg Arg Lys Lys Lys Val Tyr Val Gly 
                165                 170                 175     


Gly Leu Glu Ser Arg Val Leu Lys Tyr Xaa Ala Gln Asn Met Glu Leu 
            180                 185                 190         


Gln Asn Lys Val Gln Leu Leu Glu Glu Gln Asn Leu Ser Leu Leu Asp 
        195                 200                 205             


Gln Leu Arg Lys Leu Gln Ala Met Val Ile Glu Ile Ser Asn Lys Xaa 
    210                 215                 220                 


Ser Ser Ser Ser Xaa Cys Ile Leu Val Leu Leu Val Ser Phe Cys Leu 
225                 230                 235                 240 


Leu Leu Val Pro Ala Met Tyr Ser Ser Asp Xaa Arg Gly Ser Leu Pro 
                245                 250                 255     


Ala Glu His Gly Val Leu Ser Arg Gln Leu Arg Ala Leu Pro Ser Glu 
            260                 265                 270         


Asp Pro Tyr Gln Leu Glu Leu Pro Ala Leu Gln Ser Glu Val Pro Lys 
        275                 280                 285             


Asp Ser Xaa His Gln Trp Leu Asp Gly Ser Asp Cys Val Leu Gln Ala 
    290                 295                 300                 


Pro Gly Asn Xaa Ser Cys Leu Leu His Tyr Met Pro Gln Ala Pro Ser 
305                 310                 315                 320 


Ala Glu Pro Pro Leu Glu Trp Pro Phe Pro Asp Leu Phe Ser Glu Pro 
                325                 330                 335     


Leu Cys Arg Gly Pro Ile Leu Pro Leu Gln Ala Asn Leu Xaa Arg Lys 
            340                 345                 350         


Gly Gly Trp Leu Pro Xaa Gly Ser Pro Ser Val Ile Leu Gln Asp Arg 
        355                 360                 365             


Tyr Ser Gly 
    370     


<210> 6864
<211> 123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<400> 6864
Ile Ser Xaa Ser Pro Leu Leu Xaa Ala Pro His Lys Leu Gln Gly Xaa 
1               5                   10                  15      


Ser Gly Pro Leu Leu Leu Xaa Glu Glu Glu Lys Arg Xaa Leu Ile Ala 
            20                  25                  30          


Glu Gly Tyr Pro Ile Pro Xaa Lys Leu Pro Leu Xaa Lys Ala Glu Glu 
        35                  40                  45              


Lys Ala Leu Lys Arg Val Arg Arg Lys Ile Lys Asn Lys Ile Ser Ala 
    50                  55                  60                  


Gln Glu Ser Arg Arg Lys Lys Lys Glu Tyr Val Glu Cys Leu Glu Lys 
65                  70                  75                  80  


Lys Val Glu Xaa Phe Xaa Ser Glu Asn Asn Glu Leu Trp Lys Lys Val 
                85                  90                  95      


Glu Xaa Leu Glu Asn Ala Asn Ser Phe Ser Ser Gly Ile Gln Pro Leu 
            100                 105                 110         


Leu Cys Ser Leu Ile Gly Leu Glu Asn Pro Xaa 
        115                 120             


<210> 6865
<211> 519
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(515)
<223> Selenocysteine

<400> 6865
Met Asp Ala Val Leu Glu Pro Phe Pro Ala Asp Arg Leu Phe Pro Gly 
1               5                   10                  15      


Ser Ser Phe Leu Asp Leu Gly Asp Leu Asn Glu Ser Asp Phe Leu Asn 
            20                  25                  30          


Asn Ala His Phe Pro Glu His Leu Asp His Phe Xaa Glu Asn Met Glu 
        35                  40                  45              


Asp Phe Ser Asn Asp Leu Phe Ser Ser Phe Phe Asp Asp Pro Val Leu 
    50                  55                  60                  


Asp Glu Lys Ser Pro Leu Leu Asp Met Glu Leu Asp Ser Pro Xaa Pro 
65                  70                  75                  80  


Gly Ile Gln Ala Glu His Ser Tyr Ser Leu Ser Gly Asp Ser Ala Pro 
                85                  90                  95      


Gln Ser Pro Leu Val Pro Ile Lys Met Glu Asp Xaa Xaa Gln Asp Ala 
            100                 105                 110         


Glu His Gly Ala Trp Ala Leu Gly His Lys Leu Cys Ser Ile Met Val 
        115                 120                 125             


Lys Gln Glu Gln Ser Pro Glu Leu Pro Val Asp Pro Leu Ala Ala Pro 
    130                 135                 140                 


Ser Ala Met Ala Ala Ala Ala Ala Met Ala Xaa Xaa Pro Leu Leu Gly 
145                 150                 155                 160 


Leu Ser Pro Leu Ser Arg Leu Pro Ile Pro His Gln Ala Pro Gly Glu 
                165                 170                 175     


Met Xaa Gln Leu Pro Val Ile Lys Ala Glu Pro Leu Glu Val Asn Gln 
            180                 185                 190         


Phe Leu Lys Val Xaa Pro Glu Asp Leu Val Gln Met Pro Pro Xaa Pro 
        195                 200                 205             


Pro Ser Ser His Gly Ser Asp Ser Asp Gly Ser Gln Ser Pro Arg Ser 
    210                 215                 220                 


Leu Pro Pro Ser Ser Pro Val Arg Pro Met Ala Arg Ser Ser Xaa Ala 
225                 230                 235                 240 


Ile Ser Xaa Ser Pro Leu Leu Xaa Ala Pro His Lys Leu Gln Gly Xaa 
                245                 250                 255     


Ser Gly Pro Leu Leu Leu Xaa Glu Glu Glu Lys Arg Xaa Leu Ile Ala 
            260                 265                 270         


Glu Gly Tyr Pro Ile Pro Xaa Lys Leu Pro Leu Xaa Lys Ala Glu Glu 
        275                 280                 285             


Lys Ala Leu Lys Arg Val Arg Arg Lys Ile Lys Asn Lys Ile Ser Ala 
    290                 295                 300                 


Gln Glu Ser Arg Arg Lys Lys Lys Glu Tyr Val Glu Cys Leu Glu Lys 
305                 310                 315                 320 


Lys Val Glu Xaa Phe Xaa Ser Glu Asn Asn Glu Leu Trp Lys Lys Val 
                325                 330                 335     


Glu Xaa Leu Glu Asn Ala Asn Arg Xaa Leu Leu Gln Gln Leu Gln Lys 
            340                 345                 350         


Leu Gln Xaa Leu Val Xaa Asn Lys Ile Ser Arg Pro Tyr Lys Met Ala 
        355                 360                 365             


Ala Xaa Gln Xaa Gly Xaa Cys Leu Met Val Ala Ala Leu Cys Phe Val 
    370                 375                 380                 


Leu Val Leu Gly Ser Leu Val Pro Cys Leu Pro Glu Phe Ser Ser Gly 
385                 390                 395                 400 


Ser Gln Xaa Val Lys Glu Asp Pro Leu Ala Ala Asp Gly Val Tyr Xaa 
                405                 410                 415     


Ala Ser Gln Met Pro Ser Arg Ser Leu Leu Phe Tyr Asp Asp Gly Ala 
            420                 425                 430         


Gly Leu Trp Glu Asp Gly Arg Ser Xaa Leu Leu Pro Met Glu Pro Pro 
        435                 440                 445             


Asp Gly Trp Glu Ile Asn Pro Gly Gly Pro Ala Glu Gln Arg Pro Arg 
    450                 455                 460                 


Asp His Leu Gln His Asp His Leu Asp Ser Xaa His Glu Xaa Xaa Lys 
465                 470                 475                 480 


Tyr Leu Ser Glu Ala Trp Pro Lys Asp Gly Gly Asn Gly Xaa Ser Pro 
                485                 490                 495     


Asp Phe Ser His Ser Lys Glu Trp Phe His Asp Arg Asp Leu Gly Pro 
            500                 505                 510         


Asn Xaa Xaa Ile Lys Leu Ser 
        515                 


<210> 6866
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(63)
<223> Selenocysteine

<400> 6866
Met Glu Asp Phe Ser Asn Asp Leu Phe Ser Ser Phe Phe Asp Asp Pro 
1               5                   10                  15      


Val Leu Asp Glu Lys Ser Pro Leu Leu Asp Met Glu Leu Asp Ser Pro 
            20                  25                  30          


Xaa Pro Gly Ile Gln Ala Glu His Ser Tyr Ser Leu Ser Gly Asp Ser 
        35                  40                  45              


Ala Pro Gln Ser Pro Leu Val Pro Ile Lys Met Glu Asp Xaa Xaa Gln 
    50                  55                  60                  


Asp Ala Glu His Gly Ala Trp Ala Leu Gly His Lys Leu Cys Ser Ile 
65                  70                  75                  80  


Met Val Lys Gln Glu Gln Ser Pro Glu Leu Pro Val Asp Pro Leu Ala 
                85                  90                  95      


Ala Pro Ser Ala Met Ala Ala Ala Ala Ala 
            100                 105     


<210> 6867
<211> 185
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 6867
Met Glu Val Glu Pro Ser Pro Xaa Ser Pro Ala Pro Leu Ile Gln Ala 
1               5                   10                  15      


Glu His Ser Tyr Ser Leu Cys Glu Glu Pro Arg Ala Gln Ser Pro Phe 
            20                  25                  30          


Xaa His Ile Xaa Xaa Ser Asp Ser Phe Asn Asp Asp Glu Val Glu Ser 
        35                  40                  45              


Glu Lys Trp Tyr Leu Ser Xaa Asp Phe Pro Ser Xaa Ser Ile Lys Xaa 
    50                  55                  60                  


Glu Pro Val Xaa Asp Glu Pro Pro Pro Gly Leu Val Pro Ser Val Xaa 
65                  70                  75                  80  


Leu Xaa Ile Xaa Ala Ile Ser Xaa Pro Leu Glu Lys Glu Glu Pro Pro 
                85                  90                  95      


Leu Glu Met Asn Xaa Gly Val Asp Ser Ser Cys Gln Xaa Ile Ile Pro 
            100                 105                 110         


Lys Ile Lys Leu Glu Pro His Glu Val Asp Gln Phe Leu Asn Phe Ser 
        115                 120                 125             


Pro Lys Glu Gly Leu Ser Ala Leu Pro Val Ser Leu Trp Val Met Asp 
    130                 135                 140                 


Met Val Ser Gly Ser Xaa Glu Arg Glu Tyr Gly Glu Arg Ala Gly Met 
145                 150                 155                 160 


Ser Leu Tyr His Arg Cys Cys Ser Trp Leu Tyr Glu Ile Ala Leu Phe 
                165                 170                 175     


Leu Lys Asn Lys Asn Phe Ala Ser Lys 
            180                 185 


<210> 6868
<211> 150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<400> 6868
Met Glu Val Leu Glu Ser Gly Glu Gln Gly Val Leu Gln Trp Asp Arg 
1               5                   10                  15      


Lys Leu Ser Glu Leu Ser Glu Pro Gly Asp Gly Glu Ala Leu Met Tyr 
            20                  25                  30          


His Xaa His Phe Ser Glu Leu Leu Asp Glu Phe Ser Gln Asn Val Leu 
        35                  40                  45              


Gly Gln Leu Leu Asn Asp Pro Phe Leu Ser Glu Lys Ser Val Ser Met 
    50                  55                  60                  


Glu Val Glu Pro Ser Pro Xaa Ser Pro Ala Pro Leu Ile Gln Ala Glu 
65                  70                  75                  80  


His Ser Tyr Ser Leu Cys Glu Glu Pro Arg Ala Gln Ser Pro Phe Xaa 
                85                  90                  95      


His Ile Xaa Xaa Ser Asp Ser Phe Asn Asp Asp Glu Val Glu Ser Glu 
            100                 105                 110         


Lys Trp Tyr Leu Ser Xaa Asp Phe Pro Ser Xaa Ser Ile Cys His Ser 
        115                 120                 125             


Asp His His Ser His Leu His Pro Val Gly Lys Gly Gly Xaa Ser Ser 
    130                 135                 140                 


Gly Asn Glu His Trp Gly 
145                 150 


<210> 6869
<211> 460
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<400> 6869
Met Glu Val Leu Glu Ser Gly Glu Gln Gly Val Leu Gln Trp Asp Arg 
1               5                   10                  15      


Lys Leu Ser Glu Leu Ser Glu Pro Gly Asp Gly Glu Ala Leu Met Tyr 
            20                  25                  30          


His Xaa His Phe Ser Glu Leu Leu Asp Glu Phe Ser Gln Asn Val Leu 
        35                  40                  45              


Gly Gln Leu Leu Asn Asp Pro Phe Leu Ser Glu Lys Ser Val Ser Met 
    50                  55                  60                  


Glu Val Glu Pro Ser Pro Xaa Ser Pro Ala Pro Leu Ile Gln Ala Glu 
65                  70                  75                  80  


His Ser Tyr Ser Leu Cys Glu Glu Pro Arg Ala Gln Ser Pro Phe Xaa 
                85                  90                  95      


His Ile Xaa Xaa Ser Asp Ser Phe Asn Asp Asp Glu Val Glu Ser Glu 
            100                 105                 110         


Lys Trp Tyr Leu Ser Xaa Asp Phe Pro Ser Xaa Ser Ile Lys Xaa Glu 
        115                 120                 125             


Pro Val Xaa Asp Glu Pro Pro Pro Gly Leu Val Pro Ser Val Xaa Leu 
    130                 135                 140                 


Xaa Ile Xaa Ala Ile Ser Xaa Pro Leu Glu Lys Glu Glu Pro Pro Leu 
145                 150                 155                 160 


Glu Met Asn Xaa Gly Val Asp Ser Ser Cys Gln Xaa Ile Ile Pro Lys 
                165                 170                 175     


Ile Lys Leu Glu Pro His Glu Val Asp Gln Phe Leu Asn Phe Ser Pro 
            180                 185                 190         


Lys Glu Ala Pro Val Asp His Leu His Leu Pro Pro Xaa Pro Pro Ser 
        195                 200                 205             


Ser His Gly Ser Asp Ser Glu Gly Ser Leu Ser Pro Asn Pro Arg Leu 
    210                 215                 220                 


His Pro Phe Ser Leu Pro Gln Xaa His Ser Pro Ser Arg Ala Ala Pro 
225                 230                 235                 240 


Arg Ala Pro Ser Ala Leu Ser Ser Ser Pro Leu Leu Xaa Ala Pro His 
                245                 250                 255     


Lys Leu Gln Gly Ser Gly Pro Leu Val Leu Xaa Glu Glu Glu Lys Arg 
            260                 265                 270         


Xaa Leu Ile Ala Glu Gly Tyr Pro Ile Pro Xaa Lys Leu Pro Leu Ser 
        275                 280                 285             


Lys Ser Glu Glu Lys Ala Leu Lys Lys Ile Arg Arg Lys Ile Lys Asn 
    290                 295                 300                 


Lys Ile Ser Ala Gln Glu Ser Arg Arg Lys Lys Lys Glu Tyr Met Asp 
305                 310                 315                 320 


Ser Leu Glu Lys Lys Val Glu Ser Cys Ser Xaa Glu Asn Leu Glu Leu 
                325                 330                 335     


Arg Lys Lys Val Glu Val Leu Glu Asn Xaa Asn Arg Xaa Leu Leu Gln 
            340                 345                 350         


Gln Leu Gln Lys Leu Gln Xaa Leu Val Met Gly Lys Val Ser Arg Xaa 
        355                 360                 365             


Cys Lys Leu Ala Gly Xaa Gln Xaa Gly Xaa Cys Leu Met Val Val Val 
    370                 375                 380                 


Leu Cys Phe Ala Val Ala Phe Gly Ser Phe Phe Gln Gly Tyr Gly Pro 
385                 390                 395                 400 


Tyr Pro Ser Ala Xaa Lys Met Ala Leu Pro Ser Gln His Ser Leu Gln 
                405                 410                 415     


Glu Pro Tyr Xaa Ala Ser Val Gly Lys Xaa Ala Cys Gly Lys Leu Gly 
            420                 425                 430         


Arg Val Leu Phe Tyr Phe Pro Arg Ala Gly Phe Leu Ser Leu Pro Lys 
        435                 440                 445             


Gly Ile Phe Cys Glu Ser Pro Met Phe Lys Lys Trp 
    450                 455                 460 


<210> 6870
<211> 520
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(519)
<223> Selenocysteine

<400> 6870
Met Glu Val Leu Glu Ser Gly Glu Gln Gly Val Leu Gln Trp Asp Arg 
1               5                   10                  15      


Lys Leu Ser Glu Leu Ser Glu Pro Gly Asp Gly Glu Ala Leu Met Tyr 
            20                  25                  30          


His Xaa His Phe Ser Glu Leu Leu Asp Glu Phe Ser Gln Asn Val Leu 
        35                  40                  45              


Gly Gln Leu Leu Asn Asp Pro Phe Leu Ser Glu Lys Ser Val Ser Met 
    50                  55                  60                  


Glu Val Glu Pro Ser Pro Xaa Ser Pro Ala Pro Leu Ile Gln Ala Glu 
65                  70                  75                  80  


His Ser Tyr Ser Leu Cys Glu Glu Pro Arg Ala Gln Ser Pro Phe Xaa 
                85                  90                  95      


His Ile Xaa Xaa Ser Asp Ser Phe Asn Asp Asp Glu Val Glu Ser Glu 
            100                 105                 110         


Lys Trp Tyr Leu Ser Xaa Asp Phe Pro Ser Xaa Ser Ile Lys Xaa Glu 
        115                 120                 125             


Pro Val Xaa Asp Glu Pro Pro Pro Gly Leu Val Pro Ser Val Xaa Leu 
    130                 135                 140                 


Xaa Ile Xaa Ala Ile Ser Xaa Pro Leu Glu Lys Glu Glu Pro Pro Leu 
145                 150                 155                 160 


Glu Met Asn Xaa Gly Val Asp Ser Ser Cys Gln Xaa Ile Ile Pro Lys 
                165                 170                 175     


Ile Lys Leu Glu Pro His Glu Val Asp Gln Phe Leu Asn Phe Ser Pro 
            180                 185                 190         


Lys Glu Ala Pro Val Asp His Leu His Leu Pro Pro Xaa Pro Pro Ser 
        195                 200                 205             


Ser His Gly Ser Asp Ser Glu Gly Ser Leu Ser Pro Asn Pro Arg Leu 
    210                 215                 220                 


His Pro Phe Ser Leu Pro Gln Xaa His Ser Pro Ser Arg Ala Ala Pro 
225                 230                 235                 240 


Arg Ala Pro Ser Ala Leu Ser Ser Ser Pro Leu Leu Xaa Ala Pro His 
                245                 250                 255     


Lys Leu Gln Gly Ser Gly Pro Leu Val Leu Xaa Glu Glu Glu Lys Arg 
            260                 265                 270         


Xaa Leu Ile Ala Glu Gly Tyr Pro Ile Pro Xaa Lys Leu Pro Leu Ser 
        275                 280                 285             


Lys Ser Glu Glu Lys Ala Leu Lys Lys Ile Arg Arg Lys Ile Lys Asn 
    290                 295                 300                 


Lys Ile Ser Ala Gln Glu Ser Arg Arg Lys Lys Lys Glu Tyr Met Asp 
305                 310                 315                 320 


Ser Leu Glu Lys Lys Val Glu Ser Cys Ser Xaa Glu Asn Leu Glu Leu 
                325                 330                 335     


Arg Lys Lys Val Glu Val Leu Glu Asn Xaa Asn Arg Xaa Leu Leu Gln 
            340                 345                 350         


Gln Leu Gln Lys Leu Gln Xaa Leu Val Met Gly Lys Val Ser Arg Xaa 
        355                 360                 365             


Cys Lys Leu Ala Gly Xaa Gln Xaa Gly Xaa Cys Leu Met Val Val Val 
    370                 375                 380                 


Leu Cys Phe Ala Val Ala Phe Gly Ser Phe Phe Gln Gly Tyr Gly Pro 
385                 390                 395                 400 


Tyr Pro Ser Ala Xaa Lys Met Ala Leu Pro Ser Gln His Ser Leu Gln 
                405                 410                 415     


Glu Pro Tyr Xaa Ala Ser Val Val Arg Ser Arg Asn Leu Leu Ile Tyr 
            420                 425                 430         


Glu Glu His Ser Pro Pro Glu Glu Ser Ser Ser Pro Gly Ser Ala Gly 
        435                 440                 445             


Glu Leu Gly Gly Trp Asp Arg Gly Ser Ser Leu Leu Arg Val Ser Gly 
    450                 455                 460                 


Leu Glu Ser Arg Pro Asp Val Asp Leu Pro His Phe Ile Ile Ser Asn 
465                 470                 475                 480 


Glu Xaa Ser Leu Glu Lys Ser Val Leu Leu Glu Leu Gln Gln His Leu 
                485                 490                 495     


Val Ser Ala Lys Leu Glu Gly Asn Glu Xaa Leu Lys Val Val Glu Leu 
            500                 505                 510         


Asp Arg Arg Val Asn Xaa Xaa Phe 
        515                 520 


<210> 6871
<211> 248
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<400> 6871
Met Glu Val Leu Glu Ser Gly Glu Gln Gly Val Leu Gln Trp Asp Arg 
1               5                   10                  15      


Lys Leu Ser Glu Leu Ser Glu Pro Gly Asp Gly Glu Ala Leu Met Tyr 
            20                  25                  30          


His Xaa His Phe Ser Glu Leu Leu Asp Glu Phe Ser Gln Asn Val Leu 
        35                  40                  45              


Gly Gln Leu Leu Asn Asp Pro Phe Leu Ser Glu Lys Ser Val Ser Met 
    50                  55                  60                  


Glu Val Glu Pro Ser Pro Xaa Ser Pro Ala Pro Leu Ile Gln Ala Glu 
65                  70                  75                  80  


His Ser Tyr Ser Leu Cys Glu Glu Pro Arg Ala Gln Ser Pro Phe Xaa 
                85                  90                  95      


His Ile Xaa Xaa Ser Asp Ser Phe Asn Asp Asp Glu Val Glu Ser Glu 
            100                 105                 110         


Lys Trp Tyr Leu Ser Xaa Asp Phe Pro Ser Xaa Ser Ile Lys Xaa Glu 
        115                 120                 125             


Pro Val Xaa Asp Glu Pro Pro Pro Gly Leu Val Pro Ser Val Xaa Leu 
    130                 135                 140                 


Xaa Ile Xaa Ala Ile Ser Xaa Pro Leu Glu Lys Glu Glu Pro Pro Leu 
145                 150                 155                 160 


Glu Met Asn Xaa Gly Val Asp Ser Ser Cys Gln Xaa Ile Ile Pro Lys 
                165                 170                 175     


Ile Lys Leu Glu Pro His Glu Val Asp Gln Phe Leu Asn Phe Ser Pro 
            180                 185                 190         


Lys Glu Gly Leu Ser Ala Leu Pro Val Ser Leu Trp Val Met Asp Met 
        195                 200                 205             


Val Ser Gly Ser Xaa Glu Arg Glu Tyr Gly Glu Arg Ala Gly Met Ser 
    210                 215                 220                 


Leu Tyr His Arg Cys Cys Ser Trp Leu Tyr Glu Ile Ala Leu Phe Leu 
225                 230                 235                 240 


Lys Asn Lys Asn Phe Ala Ser Lys 
                245             


<210> 6872
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(175)
<223> Selenocysteine

<400> 6872
Met Glu Val Leu Glu Ser Gly Glu Gln Gly Val Leu Gln Trp Asp Arg 
1               5                   10                  15      


Lys Leu Ser Glu Leu Ser Glu Pro Gly Asp Gly Glu Ala Leu Met Tyr 
            20                  25                  30          


His Xaa His Phe Ser Glu Leu Leu Asp Glu Phe Ser Gln Asn Val Leu 
        35                  40                  45              


Gly Gln Leu Leu Asn Asp Pro Phe Leu Ser Glu Lys Ser Val Ser Met 
    50                  55                  60                  


Glu Val Glu Pro Ser Pro Xaa Ser Pro Ala Pro Leu Ile Gln Ala Glu 
65                  70                  75                  80  


His Ser Tyr Ser Leu Cys Glu Glu Pro Arg Ala Gln Ser Pro Phe Xaa 
                85                  90                  95      


His Ile Xaa Xaa Ser Asp Ser Phe Asn Asp Asp Glu Val Glu Ser Glu 
            100                 105                 110         


Lys Trp Tyr Leu Ser Xaa Asp Phe Pro Ser Xaa Ser Ile Lys Xaa Glu 
        115                 120                 125             


Pro Val Xaa Asp Glu Pro Pro Pro Gly Leu Val Pro Ser Val Xaa Leu 
    130                 135                 140                 


Xaa Ile Xaa Ala Ile Ser Xaa Pro Leu Glu Lys Glu Glu Pro Pro Leu 
145                 150                 155                 160 


Glu Met Asn Xaa Gly Val Asp Ser Ser Cys Gln Xaa Asn Xaa Xaa 
                165                 170                 175 


<210> 6873
<211> 240
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<400> 6873
Asn Leu Pro Arg Arg Pro Arg Arg Leu Ser Ser Arg Leu Ser Xaa Ala 
1               5                   10                  15      


Xaa Pro Cys Ala Arg Ser Leu Gly Pro Ser Arg Pro Ser Pro Xaa Leu 
            20                  25                  30          


Pro Pro Val Xaa Ala Ser Met Xaa Ile Cys Tyr Ile Asn Ser Lys Trp 
        35                  40                  45              


Met Tyr Gly Pro Pro Ser Leu Cys Leu Gly Phe Ala Ser Tyr Glu Tyr 
    50                  55                  60                  


Cys Ile Phe Asn Pro Arg Leu Phe Glu Lys Asn Leu Leu Val Ser Gly 
65                  70                  75                  80  


Pro Ala Trp Phe Lys Xaa Arg Val Val Gln Gly Pro Xaa Ala Tyr Val 
                85                  90                  95      


Phe Phe Ser Tyr Glu Val Glu Ser Glu Lys Trp Tyr Leu Ser Xaa Asp 
            100                 105                 110         


Phe Pro Ser Xaa Ser Ile Lys Xaa Glu Pro Val Xaa Asp Glu Pro Pro 
        115                 120                 125             


Pro Gly Leu Val Pro Ser Val Xaa Leu Xaa Ile Xaa Ala Ile Ser Xaa 
    130                 135                 140                 


Pro Leu Glu Lys Glu Glu Pro Pro Leu Glu Met Asn Xaa Gly Val Asp 
145                 150                 155                 160 


Ser Ser Cys Gln Xaa Ile Ile Pro Lys Ile Lys Leu Glu Pro His Glu 
                165                 170                 175     


Val Asp Gln Phe Leu Asn Phe Ser Pro Lys Glu Gly Leu Ser Ala Leu 
            180                 185                 190         


Pro Val Ser Leu Trp Val Met Asp Met Val Ser Gly Ser Xaa Glu Arg 
        195                 200                 205             


Glu Tyr Gly Glu Arg Ala Gly Met Ser Leu Tyr His Arg Cys Cys Ser 
    210                 215                 220                 


Trp Leu Tyr Glu Ile Ala Leu Phe Leu Lys Asn Lys Asn Phe Ala Ser 
225                 230                 235                 240 


<210> 6874
<211> 459
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<400> 6874
Met Asn Xaa Asp Leu Ala Ala Gly Lys Met Ala Ser Ala Ala Cys Ser 
1               5                   10                  15      


Met Asp Pro Ile Asp Ser Phe Glu Leu Leu Asp Leu Leu Phe Asp Arg 
            20                  25                  30          


Gln Asp Gly Ile Leu Arg His Val Glu Leu Gly Glu Gly Trp Gly His 
        35                  40                  45              


Val Lys Asp Gln Gln Val Leu Pro Asn Pro Asp Ser Asp Asp Phe Leu 
    50                  55                  60                  


Ser Ser Ile Leu Gly Ser Gly Asp Ser Leu Pro Ser Ser Pro Leu Trp 
65                  70                  75                  80  


Ser Pro Glu Gly Ser Asp Ser Gly Ile Ser Glu Asp Leu Pro Ser Asp 
                85                  90                  95      


Pro Gln Asp Xaa Pro Pro Arg Ser Gly Pro Ala Xaa Ser Pro Ala Gly 
            100                 105                 110         


Cys His Pro Ala Gln Pro Gly Lys Gly Pro Cys Leu Ser Tyr His Pro 
        115                 120                 125             


Gly Asn Ser Cys Ser Xaa Xaa Xaa Pro Gly Pro Val Ile Gln Val Pro 
    130                 135                 140                 


Glu Ala Ser Val Xaa Ile Asp Leu Glu Met Trp Ser Pro Gly Gly Arg 
145                 150                 155                 160 


Ile Cys Ala Glu Lys Pro Ala Asp Pro Val Asp Leu Ser Pro Arg Cys 
                165                 170                 175     


Asn Leu Xaa Val Lys Asp Leu Leu Leu Ser Gly Ser Ser Gly Asp Leu 
            180                 185                 190         


His His Leu Gly Ala Ser Tyr Leu Leu Arg Pro Gly Ala Gly His Cys 
        195                 200                 205             


Gln Glu Leu Val Leu Xaa Glu Asp Glu Lys Lys Leu Leu Ala Lys Glu 
    210                 215                 220                 


Gly Ile Xaa Leu Pro Xaa Gln Leu Pro Leu Xaa Lys Tyr Glu Glu Arg 
225                 230                 235                 240 


Val Leu Lys Lys Ile Arg Arg Lys Ile Arg Asn Lys Gln Ser Ala Gln 
                245                 250                 255     


Glu Ser Arg Lys Lys Lys Lys Glu Tyr Ile Asp Gly Leu Glu Xaa Arg 
            260                 265                 270         


Met Ser Ala Cys Xaa Ala Gln Asn Gln Glu Leu Gln Arg Lys Val Leu 
        275                 280                 285             


His Leu Glu Lys Gln Asn Leu Ser Leu Leu Glu Gln Leu Lys Lys Leu 
    290                 295                 300                 


Gln Ala Ile Val Val Gln Ser Xaa Ser Lys Ser Ala Gln Xaa Gly Xaa 
305                 310                 315                 320 


Cys Val Ala Val Leu Leu Leu Ser Phe Ala Leu Ile Ile Leu Pro Ser 
                325                 330                 335     


Ile Ser Pro Phe Gly Pro Asn Lys Xaa Glu Ser Pro Gly Asp Phe Ala 
            340                 345                 350         


Pro Val Arg Val Phe Ser Arg Xaa Leu His Asn Asp Ala Ala Ser Arg 
        355                 360                 365             


Val Ala Ala Asp Ala Val Pro Gly Ser Glu Ala Pro Gly Pro Arg Pro 
    370                 375                 380                 


Glu Ala Asp Xaa Xaa Arg Glu Glu Ser Pro Gly Ser Pro Gly Ala Asp 
385                 390                 395                 400 


Trp Gly Phe Gln Asp Xaa Ala Asn Leu Xaa Asn Ser Xaa Glu Glu Leu 
                405                 410                 415     


Asp Asn Ala Xaa Leu Val Leu Arg Asn Ala Xaa Glu Gly Leu Gly Gln 
            420                 425                 430         


Val Ala Leu Leu Asp Trp Val Ala Pro Gly Pro Ser Xaa Gly Ser Gly 
        435                 440                 445             


Arg Ala Gly Leu Glu Ala Ala Gly Asp Glu Leu 
    450                 455                 


<210> 6875
<211> 337
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<400> 6875
Met Asn Xaa Asp Leu Ala Ala Gly Lys Met Ala Ser Ala Ala Cys Ser 
1               5                   10                  15      


Met Asp Pro Ile Asp Ser Phe Glu Leu Leu Asp Leu Leu Phe Asp Arg 
            20                  25                  30          


Gln Asp Gly Ile Leu Arg His Val Glu Leu Gly Glu Gly Trp Gly His 
        35                  40                  45              


Val Lys Asp Gln Gln Val Leu Pro Asn Pro Asp Ser Asp Asp Phe Leu 
    50                  55                  60                  


Ser Ser Ile Leu Gly Ser Gly Asp Ser Leu Pro Ser Ser Pro Leu Trp 
65                  70                  75                  80  


Ser Pro Glu Gly Ser Asp Ser Gly Ile Ser Glu Asp Leu Pro Ser Asp 
                85                  90                  95      


Pro Gln Asp Xaa Pro Pro Arg Ser Gly Pro Ala Xaa Ser Pro Ala Gly 
            100                 105                 110         


Cys His Pro Ala Gln Pro Gly Lys Gly Pro Cys Leu Ser Tyr His Pro 
        115                 120                 125             


Gly Asn Ser Cys Ser Xaa Xaa Xaa Pro Gly Pro Val Ile Gln Val Pro 
    130                 135                 140                 


Glu Ala Ser Val Xaa Ile Asp Leu Glu Met Trp Ser Pro Gly Gly Arg 
145                 150                 155                 160 


Ile Cys Ala Glu Lys Pro Ala Asp Pro Val Asp Leu Ser Pro Arg Cys 
                165                 170                 175     


Asn Leu Xaa Val Lys Asp Leu Leu Leu Ser Gly Ser Ser Gly Asp Leu 
            180                 185                 190         


Gln Gln His His Leu Gly Ala Ser Tyr Leu Leu Arg Pro Gly Ala Gly 
        195                 200                 205             


His Cys Gln Glu Leu Val Leu Xaa Glu Asp Glu Lys Lys Leu Leu Ala 
    210                 215                 220                 


Lys Glu Gly Ile Xaa Leu Pro Xaa Gln Leu Pro Leu Xaa Lys Asp Val 
225                 230                 235                 240 


Ser Leu His Cys Ser Glu Ser Gly Val Xaa Glu Glu Ser Leu Ala Ser 
                245                 250                 255     


Arg Glu Ala Lys Pro Val Pro Leu Gly Ala Xaa Glu Glu Xaa Pro Gly 
            260                 265                 270         


His Cys Gly Ala Val His Gln Gln Val Ser Pro Asp Arg His Leu Cys 
        275                 280                 285             


Arg Ser Pro Val Ala Val Leu Cys Pro His His Pro Pro Leu His Gln 
    290                 295                 300                 


Pro Phe Trp Pro Gln Gln Asn Arg Glu Pro Trp Gly Leu Cys Ala Cys 
305                 310                 315                 320 


Xaa Ser Val Leu Gln Asn Phe Ala Gln Arg Cys Cys Leu Pro Arg Gly 
                325                 330                 335     


Cys 
    


<210> 6876
<211> 461
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<400> 6876
Met Asn Xaa Asp Leu Ala Ala Gly Lys Met Ala Ser Ala Ala Cys Ser 
1               5                   10                  15      


Met Asp Pro Ile Asp Ser Phe Glu Leu Leu Asp Leu Leu Phe Asp Arg 
            20                  25                  30          


Gln Asp Gly Ile Leu Arg His Val Glu Leu Gly Glu Gly Trp Gly His 
        35                  40                  45              


Val Lys Asp Gln Gln Val Leu Pro Asn Pro Asp Ser Asp Asp Phe Leu 
    50                  55                  60                  


Ser Ser Ile Leu Gly Ser Gly Asp Ser Leu Pro Ser Ser Pro Leu Trp 
65                  70                  75                  80  


Ser Pro Glu Gly Ser Asp Ser Gly Ile Ser Glu Asp Leu Pro Ser Asp 
                85                  90                  95      


Pro Gln Asp Xaa Pro Pro Arg Ser Gly Pro Ala Xaa Ser Pro Ala Gly 
            100                 105                 110         


Cys His Pro Ala Gln Pro Gly Lys Gly Pro Cys Leu Ser Tyr His Pro 
        115                 120                 125             


Gly Asn Ser Cys Ser Xaa Xaa Xaa Pro Gly Pro Val Ile Gln Val Pro 
    130                 135                 140                 


Glu Ala Ser Val Xaa Ile Asp Leu Glu Met Trp Ser Pro Gly Gly Arg 
145                 150                 155                 160 


Ile Cys Ala Glu Lys Pro Ala Asp Pro Val Asp Leu Ser Pro Arg Cys 
                165                 170                 175     


Asn Leu Xaa Val Lys Asp Leu Leu Leu Ser Gly Ser Ser Gly Asp Leu 
            180                 185                 190         


Gln Gln His His Leu Gly Ala Ser Tyr Leu Leu Arg Pro Gly Ala Gly 
        195                 200                 205             


His Cys Gln Glu Leu Val Leu Xaa Glu Asp Glu Lys Lys Leu Leu Ala 
    210                 215                 220                 


Lys Glu Gly Ile Xaa Leu Pro Xaa Gln Leu Pro Leu Xaa Lys Tyr Glu 
225                 230                 235                 240 


Glu Arg Val Leu Lys Lys Ile Arg Arg Lys Ile Arg Asn Lys Gln Ser 
                245                 250                 255     


Ala Gln Glu Ser Arg Lys Lys Lys Lys Glu Tyr Ile Asp Gly Leu Glu 
            260                 265                 270         


Xaa Arg Met Ser Ala Cys Xaa Ala Gln Asn Gln Glu Leu Gln Arg Lys 
        275                 280                 285             


Val Leu His Leu Glu Lys Gln Asn Leu Ser Leu Leu Glu Gln Leu Lys 
    290                 295                 300                 


Lys Leu Gln Ala Ile Val Val Gln Ser Xaa Ser Lys Ser Ala Gln Xaa 
305                 310                 315                 320 


Gly Xaa Cys Val Ala Val Leu Leu Leu Ser Phe Ala Leu Ile Ile Leu 
                325                 330                 335     


Pro Ser Ile Ser Pro Phe Gly Pro Asn Lys Xaa Glu Ser Pro Gly Asp 
            340                 345                 350         


Phe Ala Pro Val Arg Val Phe Ser Arg Xaa Leu His Asn Asp Ala Ala 
        355                 360                 365             


Ser Arg Val Ala Ala Asp Ala Val Pro Gly Ser Glu Ala Pro Gly Pro 
    370                 375                 380                 


Arg Pro Glu Ala Asp Xaa Xaa Arg Glu Glu Ser Pro Gly Ser Pro Gly 
385                 390                 395                 400 


Ala Asp Trp Gly Phe Gln Asp Xaa Ala Asn Leu Xaa Asn Ser Xaa Glu 
                405                 410                 415     


Glu Leu Asp Asn Ala Xaa Leu Val Leu Arg Asn Ala Xaa Glu Gly Leu 
            420                 425                 430         


Gly Gln Val Ala Leu Leu Asp Trp Val Ala Pro Gly Pro Ser Xaa Gly 
        435                 440                 445             


Ser Gly Arg Ala Gly Leu Glu Ala Ala Gly Asp Glu Leu 
    450                 455                 460     


<210> 6877
<211> 460
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<400> 6877
Met Asn Xaa Asp Leu Ala Ala Gly Lys Met Ala Ser Ala Ala Cys Ser 
1               5                   10                  15      


Met Asp Pro Ile Asp Ser Phe Glu Leu Leu Asp Leu Leu Phe Asp Arg 
            20                  25                  30          


Gln Asp Gly Ile Leu Arg His Val Glu Leu Gly Glu Gly Trp Gly His 
        35                  40                  45              


Val Lys Asp Gln Val Leu Pro Asn Pro Asp Ser Asp Asp Phe Leu Ser 
    50                  55                  60                  


Ser Ile Leu Gly Ser Gly Asp Ser Leu Pro Ser Ser Pro Leu Trp Ser 
65                  70                  75                  80  


Pro Glu Gly Ser Asp Ser Gly Ile Ser Glu Asp Leu Pro Ser Asp Pro 
                85                  90                  95      


Gln Asp Xaa Pro Pro Arg Ser Gly Pro Ala Xaa Ser Pro Ala Gly Cys 
            100                 105                 110         


His Pro Ala Gln Pro Gly Lys Gly Pro Cys Leu Ser Tyr His Pro Gly 
        115                 120                 125             


Asn Ser Cys Ser Xaa Xaa Xaa Pro Gly Pro Val Ile Gln Val Pro Glu 
    130                 135                 140                 


Ala Ser Val Xaa Ile Asp Leu Glu Met Trp Ser Pro Gly Gly Arg Ile 
145                 150                 155                 160 


Cys Ala Glu Lys Pro Ala Asp Pro Val Asp Leu Ser Pro Arg Cys Asn 
                165                 170                 175     


Leu Xaa Val Lys Asp Leu Leu Leu Ser Gly Ser Ser Gly Asp Leu Gln 
            180                 185                 190         


Gln His His Leu Gly Ala Ser Tyr Leu Leu Arg Pro Gly Ala Gly His 
        195                 200                 205             


Cys Gln Glu Leu Val Leu Xaa Glu Asp Glu Lys Lys Leu Leu Ala Lys 
    210                 215                 220                 


Glu Gly Ile Xaa Leu Pro Xaa Gln Leu Pro Leu Xaa Lys Tyr Glu Glu 
225                 230                 235                 240 


Arg Val Leu Lys Lys Ile Arg Arg Lys Ile Arg Asn Lys Gln Ser Ala 
                245                 250                 255     


Gln Glu Ser Arg Lys Lys Lys Lys Glu Tyr Ile Asp Gly Leu Glu Xaa 
            260                 265                 270         


Arg Met Ser Ala Cys Xaa Ala Gln Asn Gln Glu Leu Gln Arg Lys Val 
        275                 280                 285             


Leu His Leu Glu Lys Gln Asn Leu Ser Leu Leu Glu Gln Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ala Ile Val Val Gln Ser Xaa Ser Lys Ser Ala Gln Xaa Gly 
305                 310                 315                 320 


Xaa Cys Val Ala Val Leu Leu Leu Ser Phe Ala Leu Ile Ile Leu Pro 
                325                 330                 335     


Ser Ile Ser Pro Phe Gly Pro Asn Lys Xaa Glu Ser Pro Gly Asp Phe 
            340                 345                 350         


Ala Pro Val Arg Val Phe Ser Arg Xaa Leu His Asn Asp Ala Ala Ser 
        355                 360                 365             


Arg Val Ala Ala Asp Ala Val Pro Gly Ser Glu Ala Pro Gly Pro Arg 
    370                 375                 380                 


Pro Glu Ala Asp Xaa Xaa Arg Glu Glu Ser Pro Gly Ser Pro Gly Ala 
385                 390                 395                 400 


Asp Trp Gly Phe Gln Asp Xaa Ala Asn Leu Xaa Asn Ser Xaa Glu Glu 
                405                 410                 415     


Leu Asp Asn Ala Xaa Leu Val Leu Arg Asn Ala Xaa Glu Gly Leu Gly 
            420                 425                 430         


Gln Val Ala Leu Leu Asp Trp Val Ala Pro Gly Pro Ser Xaa Gly Ser 
        435                 440                 445             


Gly Arg Ala Gly Leu Glu Ala Ala Gly Asp Glu Leu 
    450                 455                 460 


<210> 6878
<211> 228
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<400> 6878
Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Xaa Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Gly Leu Gln Glu Ser Glu Pro Glu Asp Phe 
        35                  40                  45              


Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys Ser Glu Ala Ser 
    50                  55                  60                  


Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys His Pro Asp Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Arg Ala Xaa Ser Ser Pro Met Leu Tyr Glu Val Val 
                85                  90                  95      


Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu Xaa Gly Pro Asn 
            100                 105                 110         


Val Gly Leu Ile Ser Ile Gln Leu Asp Gln Trp Ser Pro Ala Phe Met 
        115                 120                 125             


Val Pro Asp Ser Cys Met Val Ser Glu Leu Pro Phe Asp Ala His Ala 
    130                 135                 140                 


His Ile Leu Pro Arg Ala Gly Xaa Val Ala Pro Val Pro Cys Xaa Xaa 
145                 150                 155                 160 


Leu Leu Pro Cys Gln Xaa Leu Phe Leu Xaa Asp Glu Glu Lys Arg Leu 
                165                 170                 175     


Leu Gly Gln Glu Gly Val Ser Leu Pro Ser His Leu Pro Leu Xaa Lys 
            180                 185                 190         


Ala Glu Glu Arg Val Leu Lys Lys Val Arg Arg Lys Ile Arg Asn Lys 
        195                 200                 205             


Gln Ser Ala Gln Asp Ser Arg Arg Arg Lys Lys Glu Tyr Ile Asp Gly 
    210                 215                 220                 


Leu Glu Ser Arg 
225             


<210> 6879
<211> 375
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<400> 6879
Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Xaa Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Gly Leu Gln Glu Ser Glu Pro Glu Asp Phe 
        35                  40                  45              


Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys Ser Glu Ala Ser 
    50                  55                  60                  


Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys His Pro Asp Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Arg Ala Xaa Ser Ser Pro Met Leu Tyr Glu Val Val 
                85                  90                  95      


Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu Xaa Gly Pro Asn 
            100                 105                 110         


Val Gly Leu Ile Ser Ile Gln Leu Asp Gln Trp Ser Pro Ala Phe Met 
        115                 120                 125             


Val Pro Asp Ser Cys Met Val Ser Glu Leu Pro Phe Asp Ala His Ala 
    130                 135                 140                 


His Ile Leu Pro Arg Ala Gly Xaa Val Ala Pro Val Pro Cys Xaa Xaa 
145                 150                 155                 160 


Leu Leu Pro Cys Gln Xaa Leu Phe Leu Xaa Asp Glu Glu Lys Arg Leu 
                165                 170                 175     


Leu Gly Gln Glu Gly Val Ser Leu Pro Ser His Leu Pro Leu Xaa Lys 
            180                 185                 190         


Ala Glu Glu Arg Val Leu Lys Lys Val Arg Arg Lys Ile Arg Asn Lys 
        195                 200                 205             


Gln Ser Ala Gln Asp Ser Arg Arg Arg Lys Lys Glu Tyr Ile Asp Gly 
    210                 215                 220                 


Leu Glu Ser Arg Val Ala Ala Cys Ser Ala Gln Asn Gln Glu Leu Gln 
225                 230                 235                 240 


Lys Lys Val Gln Glu Leu Glu Arg His Asn Ile Ser Leu Val Ala Gln 
                245                 250                 255     


Leu Arg Gln Leu Gln Xaa Leu Ile Ala Gln Xaa Ser Asn Lys Ala Ala 
            260                 265                 270         


Gln Xaa Ser Xaa Cys Val Leu Ile Leu Leu Phe Ser Leu Ala Leu Ile 
        275                 280                 285             


Ile Leu Pro Ser Phe Ser Pro Phe Gln Ser Arg Pro Glu Ala Gly Ser 
    290                 295                 300                 


Glu Asp Tyr Gln Pro His Gly Val Xaa Ser Arg Asn Ile Leu Xaa His 
305                 310                 315                 320 


Lys Asp Val Xaa Glu Asn Leu Glu Xaa Gln Val Val Glu Ser Arg Leu 
                325                 330                 335     


Arg Glu Pro Pro Gly Ala Lys Asp Ala Asn Gly Ser Xaa Arg Xaa Leu 
            340                 345                 350         


Leu Glu Lys Met Gly Gly Lys Pro Arg Pro Ser Gly Arg Ile Arg Ser 
        355                 360                 365             


Val Leu His Ala Asp Glu Met 
    370                 375 


<210> 6880
<211> 395
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<400> 6880
Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Xaa Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Val Xaa Arg Leu Gln Glu Gln Gly Leu Gln 
        35                  40                  45              


Gly Trp Lys Ser Gly Gly Asp Arg Gly Cys Gly Leu Gln Glu Ser Glu 
    50                  55                  60                  


Pro Glu Asp Phe Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys 
65                  70                  75                  80  


Ser Glu Ala Ser Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys 
                85                  90                  95      


His Pro Asp Ser Pro Pro Ala Pro Arg Ala Xaa Ser Ser Pro Met Leu 
            100                 105                 110         


Tyr Glu Val Val Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu 
        115                 120                 125             


Xaa Gly Pro Asn Val Gly Leu Ile Ser Ile Gln Leu Asp Gln Trp Ser 
    130                 135                 140                 


Pro Ala Phe Met Val Pro Asp Ser Cys Met Val Ser Glu Leu Pro Phe 
145                 150                 155                 160 


Asp Ala His Ala His Ile Leu Pro Arg Ala Gly Xaa Val Ala Pro Val 
                165                 170                 175     


Pro Cys Xaa Xaa Leu Leu Pro Cys Gln Xaa Leu Phe Leu Xaa Asp Glu 
            180                 185                 190         


Glu Lys Arg Leu Leu Gly Gln Glu Gly Val Ser Leu Pro Ser His Leu 
        195                 200                 205             


Pro Leu Xaa Lys Ala Glu Glu Arg Val Leu Lys Lys Val Arg Arg Lys 
    210                 215                 220                 


Ile Arg Asn Lys Gln Ser Ala Gln Asp Ser Arg Arg Arg Lys Lys Glu 
225                 230                 235                 240 


Tyr Ile Asp Gly Leu Glu Ser Arg Val Ala Ala Cys Ser Ala Gln Asn 
                245                 250                 255     


Gln Glu Leu Gln Lys Lys Val Gln Glu Leu Glu Arg His Asn Ile Ser 
            260                 265                 270         


Leu Val Ala Gln Leu Arg Gln Leu Gln Xaa Leu Ile Ala Gln Xaa Ser 
        275                 280                 285             


Asn Lys Ala Ala Gln Xaa Ser Xaa Cys Val Leu Ile Leu Leu Phe Ser 
    290                 295                 300                 


Leu Ala Leu Ile Ile Leu Pro Ser Phe Ser Pro Phe Gln Ser Arg Pro 
305                 310                 315                 320 


Glu Ala Gly Ser Glu Asp Tyr Gln Pro His Gly Val Xaa Ser Arg Asn 
                325                 330                 335     


Ile Leu Xaa His Lys Asp Val Xaa Glu Asn Leu Glu Xaa Gln Val Val 
            340                 345                 350         


Glu Ser Arg Leu Arg Glu Pro Pro Gly Ala Lys Asp Ala Asn Gly Ser 
        355                 360                 365             


Xaa Arg Xaa Leu Leu Glu Lys Met Gly Gly Lys Pro Arg Pro Ser Gly 
    370                 375                 380                 


Arg Ile Arg Ser Val Leu His Ala Asp Glu Met 
385                 390                 395 


<210> 6881
<211> 217
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<400> 6881
Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Xaa Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Val Xaa Arg Leu Gln Glu Gln Gly Leu Gln 
        35                  40                  45              


Gly Trp Lys Ser Gly Gly Asp Arg Gly Cys Gly Leu Gln Glu Ser Glu 
    50                  55                  60                  


Pro Glu Asp Phe Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys 
65                  70                  75                  80  


Ser Glu Ala Ser Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys 
                85                  90                  95      


His Pro Asp Ser Pro Pro Ala Pro Arg Ala Xaa Ser Ser Pro Met Leu 
            100                 105                 110         


Tyr Glu Val Val Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu 
        115                 120                 125             


Xaa Gly Pro Asn Val Gly Leu Ile Ser Ile Gln Leu Asp Gln Trp Ser 
    130                 135                 140                 


Pro Ala Phe Met Val Pro Asp Ser Cys Met Val Ser Glu Leu Pro Phe 
145                 150                 155                 160 


Asp Ala His Ala His Ile Leu Pro Arg Ala Gly Xaa Val Ala Pro Val 
                165                 170                 175     


Pro Cys Xaa Xaa Leu Leu Pro Cys Gln Xaa Leu Phe Leu Xaa Asp Glu 
            180                 185                 190         


Glu Lys Arg Leu Leu Gly Gln Glu Gly Val Ser Leu Pro Ser His Leu 
        195                 200                 205             


Pro Leu Xaa Lys Val Xaa Cys Phe Pro 
    210                 215         


<210> 6882
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(180)
<223> Selenocysteine

<400> 6882
Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Xaa Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Val Xaa Arg Leu Gln Glu Gln Gly Leu Gln 
        35                  40                  45              


Gly Trp Lys Ser Gly Gly Asp Arg Gly Cys Gly Leu Gln Glu Ser Glu 
    50                  55                  60                  


Pro Glu Asp Phe Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys 
65                  70                  75                  80  


Ser Glu Ala Ser Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys 
                85                  90                  95      


His Pro Asp Ser Pro Pro Ala Pro Arg Ala Xaa Ser Ser Pro Met Leu 
            100                 105                 110         


Tyr Glu Val Val Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu 
        115                 120                 125             


Xaa Gly Pro Asn Val Gly Leu Ile Ser Ile Gln Leu Asp Gln Trp Ser 
    130                 135                 140                 


Pro Ala Phe Met Val Pro Asp Ser Cys Met Val Ser Glu Leu Pro Phe 
145                 150                 155                 160 


Asp Ala His Ala His Ile Leu Pro Arg Ala Gly Xaa Val Ala Pro Val 
                165                 170                 175     


Pro Cys Xaa Xaa Leu Val 
            180         


<210> 6883
<211> 39
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<400> 6883
Leu Gln Asn Glu Val Ser Met Leu Lys Asn Glu Val Ala Gln Leu Lys 
1               5                   10                  15      


Gln Leu Leu Leu Xaa His Lys Asp Cys Pro Ile Xaa Ala Met Gln Lys 
            20                  25                  30          


Glu Ser Gln Gly Tyr Leu Asn 
        35                  


<210> 6884
<211> 369
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<400> 6884
Met Phe Cys Xaa Ser Gly Gly Asn Ser Ala Ser Val Met Ser Met Arg 
1               5                   10                  15      


Pro Val Pro Gly Ser Leu Ser Ser Leu Leu His Leu His Asn Arg Gln 
            20                  25                  30          


Arg Gln Pro Met Pro Ala Ser Met Pro Gly Xaa Leu Pro Asn Pro Xaa 
        35                  40                  45              


Met Pro Gly Ser Ser Ala Val Leu Met Pro Met Glu Arg Gln Met Ser 
    50                  55                  60                  


Val Asn Ser Ser Ile Met Gly Met Gln Gly Pro Asn Leu Ser Asn Pro 
65                  70                  75                  80  


Cys Ala Ser Pro Gln Val Gln Pro Met His Ser Glu Ala Lys Met Arg 
                85                  90                  95      


Leu Lys Ala Ala Leu Xaa His His Pro Ala Ala Met Ser Asn Gly Asn 
            100                 105                 110         


Met Asn Xaa Met Gly His Met Met Glu Met Met Gly Ser Arg Gln Asp 
        115                 120                 125             


Gln Xaa Pro His His His Met His Ser His Pro His Gln His Gln Xaa 
    130                 135                 140                 


Leu Pro Pro His His Pro Tyr Pro His Gln His Gln His Pro Ala His 
145                 150                 155                 160 


His Pro His Pro Gln Pro His His Gln Gln Asn His Pro His His His 
                165                 170                 175     


Ser His Ser His Leu His Ala His Pro Ala His His Gln Xaa Ser Pro 
            180                 185                 190         


His Pro Pro Leu His Xaa Gly Asn Gln Ala Gln Val Ser Pro Ala Xaa 
        195                 200                 205             


Gln Gln Met Gln Pro Xaa Gln Xaa Ile Gln Pro Pro Gln Pro Xaa Gly 
    210                 215                 220                 


Gly Arg Arg Arg Arg Val Val Asp Glu Asp Pro Asp Glu Arg Arg Arg 
225                 230                 235                 240 


Lys Phe Leu Glu Arg Asn Arg Ala Ala Ala Xaa Arg Cys Arg Gln Lys 
                245                 250                 255     


Arg Lys Val Trp Val Met Ser Leu Glu Lys Lys Ala Glu Glu Leu Xaa 
            260                 265                 270         


Gln Xaa Asn Met Gln Leu Gln Asn Glu Val Ser Met Leu Lys Asn Glu 
        275                 280                 285             


Val Ala Gln Leu Lys Gln Leu Leu Leu Xaa His Lys Asp Cys Pro Ile 
    290                 295                 300                 


Xaa Ala Met Gln Lys Glu Ser Gln Gly Tyr Leu Ser Pro Glu Ser Ser 
305                 310                 315                 320 


Pro Pro Ala Ser Pro Val Pro Ala Cys Ser Gln Gln Gln Val Ile Gln 
                325                 330                 335     


His Asn Xaa Ile Xaa Xaa Ser Ser Ser Val Ser Glu Val Val Gly Ser 
            340                 345                 350         


Ser Xaa Leu Ser Gln Leu Xaa Xaa His Arg Xaa Asp Leu Asn Pro Ile 
        355                 360                 365             


Leu 
    


<210> 6885
<211> 475
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<400> 6885
Met Ile His Arg His Lys His Glu Met Xaa Leu Lys Phe Pro Ser Ile 
1               5                   10                  15      


Lys Xaa Asp Asn Met Leu Ser Asp Gln Xaa Pro Xaa Pro Xaa Arg Phe 
            20                  25                  30          


Leu Lys Asn Cys Glu Glu Val Gly Leu Phe Ser Glu Leu Asp Cys Ser 
        35                  40                  45              


Leu Glu His Glu Phe Arg Lys Ala Gln Glu Glu Glu Ser Ser Lys Arg 
    50                  55                  60                  


Asn Ile Ser Met His Asn Ala Val Gly Gly Ala Met Xaa Gly Pro Gly 
65                  70                  75                  80  


Xaa His Gln Leu Ser Ser Ala Arg Leu Pro Asn His Asp Xaa Asn Val 
                85                  90                  95      


Val Ile Gln Gln Ala Met Pro Ser Pro Gln Ser Ser Ser Val Ile Xaa 
            100                 105                 110         


Gln Ala Pro Ser Xaa Asn Arg Gln Ile Gly Pro Val Pro Gly Ser Leu 
        115                 120                 125             


Ser Ser Leu Leu His Leu His Asn Arg Gln Arg Gln Pro Met Pro Ala 
    130                 135                 140                 


Ser Met Pro Gly Xaa Leu Pro Asn Pro Xaa Met Pro Gly Ser Ser Ala 
145                 150                 155                 160 


Val Leu Met Pro Met Glu Arg Gln Met Ser Val Asn Ser Ser Ile Met 
                165                 170                 175     


Gly Met Gln Gly Pro Asn Leu Ser Asn Pro Cys Ala Ser Pro Gln Val 
            180                 185                 190         


Gln Pro Met His Ser Glu Ala Lys Met Arg Leu Lys Ala Ala Leu Xaa 
        195                 200                 205             


His His Pro Ala Ala Met Ser Asn Gly Asn Met Asn Xaa Met Gly His 
    210                 215                 220                 


Met Met Glu Met Met Gly Ser Arg Gln Asp Gln Xaa Pro His His His 
225                 230                 235                 240 


Met His Ser His Pro His Gln His Gln Xaa Leu Pro Pro His His Pro 
                245                 250                 255     


Tyr Pro His Gln His Gln His Pro Ala His His Pro His Pro Gln Pro 
            260                 265                 270         


His His Gln Gln Asn His Pro His His His Ser His Ser His Leu His 
        275                 280                 285             


Ala His Pro Ala His His Gln Xaa Ser Pro His Pro Pro Leu His Xaa 
    290                 295                 300                 


Gly Asn Gln Ala Gln Val Ser Pro Ala Xaa Gln Gln Met Gln Pro Xaa 
305                 310                 315                 320 


Gln Xaa Ile Gln Pro Pro Gln Pro Xaa Gly Gly Arg Arg Arg Arg Val 
                325                 330                 335     


Val Asp Glu Asp Pro Asp Glu Arg Arg Arg Lys Phe Leu Glu Arg Asn 
            340                 345                 350         


Arg Ala Ala Ala Xaa Arg Cys Arg Gln Lys Arg Lys Val Trp Val Met 
        355                 360                 365             


Ser Leu Glu Lys Lys Ala Glu Glu Leu Xaa Gln Xaa Asn Met Gln Leu 
    370                 375                 380                 


Gln Asn Glu Val Ser Met Leu Lys Asn Glu Val Ala Gln Leu Lys Gln 
385                 390                 395                 400 


Leu Leu Leu Xaa His Lys Asp Cys Pro Ile Xaa Ala Met Gln Lys Glu 
                405                 410                 415     


Ser Gln Gly Tyr Leu Ser Pro Glu Ser Ser Pro Pro Ala Ser Pro Val 
            420                 425                 430         


Pro Ala Cys Ser Gln Gln Gln Val Ile Gln His Asn Xaa Ile Xaa Xaa 
        435                 440                 445             


Ser Ser Ser Val Ser Glu Val Val Gly Ser Ser Xaa Leu Ser Gln Leu 
    450                 455                 460                 


Xaa Xaa His Arg Xaa Asp Leu Asn Pro Ile Leu 
465                 470                 475 


<210> 6886
<211> 508
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<400> 6886
Met Ile Tyr Glu Glu Ser Lys Met Asn Leu Glu Gln Glu Arg Pro Phe 
1               5                   10                  15      


Val Cys Ser Ala Pro Gly Cys Ser Gln Arg Phe Pro Xaa Glu Asp His 
            20                  25                  30          


Leu Met Ile His Arg His Lys His Glu Met Xaa Leu Lys Phe Pro Ser 
        35                  40                  45              


Ile Lys Xaa Asp Asn Met Leu Ser Asp Gln Xaa Pro Xaa Pro Xaa Arg 
    50                  55                  60                  


Phe Leu Lys Asn Cys Glu Glu Val Gly Leu Phe Ser Glu Leu Asp Cys 
65                  70                  75                  80  


Ser Leu Glu His Glu Phe Arg Lys Ala Gln Glu Glu Glu Ser Ser Lys 
                85                  90                  95      


Arg Asn Ile Ser Met His Asn Ala Val Gly Gly Ala Met Xaa Gly Pro 
            100                 105                 110         


Gly Xaa His Gln Leu Ser Ser Ala Arg Leu Pro Asn His Asp Xaa Asn 
        115                 120                 125             


Val Val Ile Gln Gln Ala Met Pro Ser Pro Gln Ser Ser Ser Val Ile 
    130                 135                 140                 


Xaa Gln Ala Pro Ser Xaa Asn Arg Gln Ile Gly Pro Val Pro Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Leu Leu His Leu His Asn Arg Gln Arg Gln Pro Met Pro 
                165                 170                 175     


Ala Ser Met Pro Gly Xaa Leu Pro Asn Pro Xaa Met Pro Gly Ser Ser 
            180                 185                 190         


Ala Val Leu Met Pro Met Glu Arg Gln Met Ser Val Asn Ser Ser Ile 
        195                 200                 205             


Met Gly Met Gln Gly Pro Asn Leu Ser Asn Pro Cys Ala Ser Pro Gln 
    210                 215                 220                 


Val Gln Pro Met His Ser Glu Ala Lys Met Arg Leu Lys Ala Ala Leu 
225                 230                 235                 240 


Xaa His His Pro Ala Ala Met Ser Asn Gly Asn Met Asn Xaa Met Gly 
                245                 250                 255     


His Met Met Glu Met Met Gly Ser Arg Gln Asp Gln Xaa Pro His His 
            260                 265                 270         


His Met His Ser His Pro His Gln His Gln Xaa Leu Pro Pro His His 
        275                 280                 285             


Pro Tyr Pro His Gln His Gln His Pro Ala His His Pro His Pro Gln 
    290                 295                 300                 


Pro His His Gln Gln Asn His Pro His His His Ser His Ser His Leu 
305                 310                 315                 320 


His Ala His Pro Ala His His Gln Xaa Ser Pro His Pro Pro Leu His 
                325                 330                 335     


Xaa Gly Asn Gln Ala Gln Val Ser Pro Ala Xaa Gln Gln Met Gln Pro 
            340                 345                 350         


Xaa Gln Xaa Ile Gln Pro Pro Gln Pro Xaa Gly Gly Arg Arg Arg Arg 
        355                 360                 365             


Val Val Asp Glu Asp Pro Asp Glu Arg Arg Arg Lys Phe Leu Glu Arg 
    370                 375                 380                 


Asn Arg Ala Ala Ala Xaa Arg Cys Arg Gln Lys Arg Lys Val Trp Val 
385                 390                 395                 400 


Met Ser Leu Glu Lys Lys Ala Glu Glu Leu Xaa Gln Xaa Asn Met Gln 
                405                 410                 415     


Leu Gln Asn Glu Val Ser Met Leu Lys Asn Glu Val Ala Gln Leu Lys 
            420                 425                 430         


Gln Leu Leu Leu Xaa His Lys Asp Cys Pro Ile Xaa Ala Met Gln Lys 
        435                 440                 445             


Glu Ser Gln Gly Tyr Leu Ser Pro Glu Ser Ser Pro Pro Ala Ser Pro 
    450                 455                 460                 


Val Pro Ala Cys Ser Gln Gln Gln Val Ile Gln His Asn Xaa Ile Xaa 
465                 470                 475                 480 


Xaa Ser Ser Ser Val Ser Glu Val Val Gly Ser Ser Xaa Leu Ser Gln 
                485                 490                 495     


Leu Xaa Xaa His Arg Xaa Asp Leu Asn Pro Ile Leu 
            500                 505             


<210> 6887
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<400> 6887
Met Asn Leu Glu Gln Glu Arg Pro Phe Val Cys Ser Ala Pro Gly Cys 
1               5                   10                  15      


Ser Gln Arg Phe Pro Xaa Glu Asp His Leu Met Ile His Arg His Lys 
            20                  25                  30          


His Glu Met Xaa Leu Lys Phe Pro Ser Ile Lys Xaa Asp Asn Met Leu 
        35                  40                  45              


Ser Asp Gln Xaa Pro Xaa Pro Xaa Arg Phe Leu Lys Asn Cys Glu Glu 
    50                  55                  60                  


Val Gly Leu Phe Ser Glu Leu Asp Cys Ser Leu Glu His Glu Phe Arg 
65                  70                  75                  80  


Lys Ala Gln Glu Glu Glu Ser Ser Lys Arg Asn Ile Ser Met His Asn 
                85                  90                  95      


Ala Val Gly Gly Ala Met Xaa Gly Pro Gly Xaa His Gln Leu Ser Ser 
            100                 105                 110         


Ala Arg Leu 
        115 


<210> 6888
<211> 501
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<400> 6888
Met Asn Leu Glu Gln Glu Arg Pro Phe Val Cys Ser Ala Pro Gly Cys 
1               5                   10                  15      


Ser Gln Arg Phe Pro Xaa Glu Asp His Leu Met Ile His Arg His Lys 
            20                  25                  30          


His Glu Met Xaa Leu Lys Phe Pro Ser Ile Lys Xaa Asp Asn Met Leu 
        35                  40                  45              


Ser Asp Gln Xaa Pro Xaa Pro Xaa Arg Phe Leu Lys Asn Cys Glu Glu 
    50                  55                  60                  


Val Gly Leu Phe Ser Glu Leu Asp Cys Ser Leu Glu His Glu Phe Arg 
65                  70                  75                  80  


Lys Ala Gln Glu Glu Glu Ser Ser Lys Arg Asn Ile Ser Met His Asn 
                85                  90                  95      


Ala Val Gly Gly Ala Met Xaa Gly Pro Gly Xaa His Gln Leu Ser Ser 
            100                 105                 110         


Ala Arg Leu Pro Asn His Asp Xaa Asn Val Val Ile Gln Gln Ala Met 
        115                 120                 125             


Pro Ser Pro Gln Ser Ser Ser Val Ile Xaa Gln Ala Pro Ser Xaa Asn 
    130                 135                 140                 


Arg Gln Ile Gly Pro Val Pro Gly Ser Leu Ser Ser Leu Leu His Leu 
145                 150                 155                 160 


His Asn Arg Gln Arg Gln Pro Met Pro Ala Ser Met Pro Gly Xaa Leu 
                165                 170                 175     


Pro Asn Pro Xaa Met Pro Gly Ser Ser Ala Val Leu Met Pro Met Glu 
            180                 185                 190         


Arg Gln Met Ser Val Asn Ser Ser Ile Met Gly Met Gln Gly Pro Asn 
        195                 200                 205             


Leu Ser Asn Pro Cys Ala Ser Pro Gln Val Gln Pro Met His Ser Glu 
    210                 215                 220                 


Ala Lys Met Arg Leu Lys Ala Ala Leu Xaa His His Pro Ala Ala Met 
225                 230                 235                 240 


Ser Asn Gly Asn Met Asn Xaa Met Gly His Met Met Glu Met Met Gly 
                245                 250                 255     


Ser Arg Gln Asp Gln Xaa Pro His His His Met His Ser His Pro His 
            260                 265                 270         


Gln His Gln Xaa Leu Pro Pro His His Pro Tyr Pro His Gln His Gln 
        275                 280                 285             


His Pro Ala His His Pro His Pro Gln Pro His His Gln Gln Asn His 
    290                 295                 300                 


Pro His His His Ser His Ser His Leu His Ala His Pro Ala His His 
305                 310                 315                 320 


Gln Xaa Ser Pro His Pro Pro Leu His Xaa Gly Asn Gln Ala Gln Val 
                325                 330                 335     


Ser Pro Ala Xaa Gln Gln Met Gln Pro Xaa Gln Xaa Ile Gln Pro Pro 
            340                 345                 350         


Gln Pro Xaa Gly Gly Arg Arg Arg Arg Val Val Asp Glu Asp Pro Asp 
        355                 360                 365             


Glu Arg Arg Arg Lys Phe Leu Glu Arg Asn Arg Ala Ala Ala Xaa Arg 
    370                 375                 380                 


Cys Arg Gln Lys Arg Lys Val Trp Val Met Ser Leu Glu Lys Lys Ala 
385                 390                 395                 400 


Glu Glu Leu Xaa Gln Xaa Asn Met Gln Leu Gln Asn Glu Val Ser Met 
                405                 410                 415     


Leu Lys Asn Glu Val Ala Gln Leu Lys Gln Leu Leu Leu Xaa His Lys 
            420                 425                 430         


Asp Cys Pro Ile Xaa Ala Met Gln Lys Glu Ser Gln Gly Tyr Leu Ser 
        435                 440                 445             


Pro Glu Ser Ser Pro Pro Ala Ser Pro Val Pro Ala Cys Ser Gln Gln 
    450                 455                 460                 


Gln Val Ile Gln His Asn Xaa Ile Xaa Xaa Ser Ser Ser Val Ser Glu 
465                 470                 475                 480 


Val Val Gly Ser Ser Xaa Leu Ser Gln Leu Xaa Xaa His Arg Xaa Asp 
                485                 490                 495     


Leu Asn Pro Ile Leu 
            500     


<210> 6889
<211> 212
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<400> 6889
Met Pro Ala Ser Met Pro Gly Xaa Leu Pro Asn Pro Xaa Met Pro Gly 
1               5                   10                  15      


Ser Ser Ala Val Leu Met Pro Met Glu Arg Gln Met Ser Val Asn Ser 
            20                  25                  30          


Ser Ile Met Gly Met Gln Gly Pro Asn Leu Ser Asn Pro Cys Ala Ser 
        35                  40                  45              


Pro Gln Val Gln Pro Met His Ser Glu Ala Lys Met Arg Leu Lys Ala 
    50                  55                  60                  


Ala Leu Xaa His His Pro Ala Ala Met Ser Asn Gly Asn Met Asn Xaa 
65                  70                  75                  80  


Met Gly His Met Met Glu Met Met Gly Ser Arg Gln Asp Gln Xaa Pro 
                85                  90                  95      


His His His Met His Ser His Pro His Gln His Gln Xaa Leu Pro Pro 
            100                 105                 110         


His His Pro Tyr Pro His Gln His Gln His Pro Ala His His Pro His 
        115                 120                 125             


Pro Gln Pro His His Gln Gln Asn His Pro His His His Ser His Ser 
    130                 135                 140                 


His Leu His Ala His Pro Ala His His Gln Xaa Ser Pro His Pro Pro 
145                 150                 155                 160 


Leu His Xaa Gly Asn Gln Ala Gln Val Ser Pro Ala Xaa Gln Gln Met 
                165                 170                 175     


Gln Pro Xaa Gln Xaa Ile Gln Pro Pro Gln Pro Xaa Gly Gly Arg Arg 
            180                 185                 190         


Arg Arg Val Val Asp Glu Asp Pro Asp Glu Arg Arg Arg Lys Phe Leu 
        195                 200                 205             


Glu Arg Asn Arg 
    210         


<210> 6890
<211> 2404
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (921)..(921)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (998)..(998)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1037)..(1037)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1106)..(1106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1133)..(1133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1182)..(1182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1222)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1236)..(1236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1277)..(1277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1293)..(1294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1330)..(1330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1355)..(1355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1388)..(1388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1409)..(1409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1430)..(1430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1489)..(1489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1494)..(1494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1531)..(1531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1536)..(1537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1586)..(1586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1607)..(1607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1631)..(1631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1650)..(1650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1659)..(1659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1668)..(1668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1678)..(1678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1683)..(1683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1697)..(1697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1767)..(1767)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1774)..(1774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1833)..(1833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1836)..(1836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1848)..(1848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1854)..(1854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1856)..(1856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1861)..(1861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1864)..(1864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1889)..(1889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1893)..(1894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1897)..(1897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1901)..(1901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1948)..(1948)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1952)..(1952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2035)..(2035)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2067)..(2067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2246)..(2246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2299)..(2299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2342)..(2342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2352)..(2352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2376)..(2376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2392)..(2393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2396)..(2396)
<223> Selenocysteine

<400> 6890
Met Ala Glu Asn Leu Leu Asp Gly Pro Pro Asn Pro Lys Arg Ala Lys 
1               5                   10                  15      


Leu Ser Ser Pro Gly Phe Ser Ala Asn Asp Ser Xaa Asp Phe Gly Ser 
            20                  25                  30          


Leu Phe Asp Leu Glu Asn Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly 
        35                  40                  45              


Gly Glu Leu Gly Leu Leu Asn Ser Gly Asn Leu Val Pro Asp Ala Ala 
    50                  55                  60                  


Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser 
65                  70                  75                  80  


Ser Ile Asn Pro Gly Ile Gly Asn Val Ser Ala Ser Ser Pro Val Gln 
                85                  90                  95      


Gln Gly Leu Gly Gly Gln Ala Gln Gly Gln Pro Asn Ser Ala Asn Met 
            100                 105                 110         


Ala Ser Leu Ser Ala Met Gly Lys Ser Pro Leu Ser Gln Gly Asp Ser 
        115                 120                 125             


Ser Ala Pro Ser Leu Pro Lys Gln Ala Ala Ser Xaa Ser Gly Pro Xaa 
    130                 135                 140                 


Pro Ala Ala Ser Gln Ala Leu Asn Pro Gln Ala Gln Lys Gln Val Gly 
145                 150                 155                 160 


Leu Ala Xaa Ser Ser Pro Ala Xaa Ser Gln Xaa Gly Pro Gly Ile Cys 
                165                 170                 175     


Met Asn Ala Asn Phe Asn Gln Xaa His Pro Gly Leu Leu Asn Ser Asn 
            180                 185                 190         


Ser Gly His Ser Leu Ile Asn Gln Ala Ser Gln Gly Gln Ala Gln Val 
        195                 200                 205             


Met Asn Gly Ser Leu Gly Ala Ala Gly Arg Gly Arg Gly Ala Gly Met 
    210                 215                 220                 


Pro Tyr Pro Xaa Pro Ala Met Gln Gly Ala Ser Ser Ser Val Leu Ala 
225                 230                 235                 240 


Glu Xaa Leu Xaa Gln Val Ser Pro Gln Met Xaa Gly His Ala Gly Leu 
                245                 250                 255     


Asn Xaa Ala Gln Ala Gly Gly Met Ala Lys Met Gly Ile Xaa Gly Asn 
            260                 265                 270         


Xaa Ser Pro Phe Gly Gln Pro Phe Ser Gln Ala Gly Gly Gln Pro Met 
        275                 280                 285             


Gly Ala Xaa Gly Val Asn Pro Gln Leu Ala Ser Lys Gln Ser Met Val 
    290                 295                 300                 


Asn Ser Leu Pro Xaa Phe Pro Xaa Asp Ile Lys Asn Xaa Ser Val Xaa 
305                 310                 315                 320 


Asn Val Pro Asn Met Ser Gln Met Gln Xaa Ser Val Gly Ile Val Pro 
                325                 330                 335     


Xaa Gln Ala Ile Ala Xaa Gly Pro Xaa Ala Asp Pro Glu Lys Arg Lys 
            340                 345                 350         


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
        355                 360                 365             


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Ala Cys Ser Leu Pro His 
    370                 375                 380                 


Cys Arg Xaa Met Lys Asn Val Leu Asn His Met Xaa His Cys Gln Ala 
385                 390                 395                 400 


Gly Lys Ala Cys Gln Ala Ile Leu Gly Ser Pro Ala Ser Gly Ile Gln 
                405                 410                 415     


Asn Xaa Ile Gly Ser Val Gly Xaa Gly Gln Gln Asn Ala Xaa Ser Leu 
            420                 425                 430         


Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser Met Gln Arg Ala Tyr Ala 
        435                 440                 445             


Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro Gln Xaa Gln Leu Gln Pro 
    450                 455                 460                 


Gln Val Pro Gly Gln Gln Pro Ala Gln Pro Gln Xaa His Gln Gln Met 
465                 470                 475                 480 


Arg Xaa Leu Asn Pro Leu Gly Asn Asn Pro Met Asn Ile Pro Ala Gly 
                485                 490                 495     


Gly Ile Xaa Xaa Asp Gln Gln Pro Pro Asn Leu Ile Ser Glu Ser Ala 
            500                 505                 510         


Leu Pro Xaa Ser Leu Gly Ala Xaa Asn Pro Leu Met Asn Asp Gly Ser 
        515                 520                 525             


Asn Ser Gly Asn Ile Gly Xaa Leu Ser Xaa Ile Pro Xaa Ala Ala Pro 
    530                 535                 540                 


Pro Ser Ser Xaa Gly Val Arg Lys Gly Trp His Glu His Val Xaa Gln 
545                 550                 555                 560 


Asp Leu Arg Ser His Leu Val His Lys Leu Val Gln Ala Ile Phe Pro 
                565                 570                 575     


Xaa Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu Val 
            580                 585                 590         


Ala Tyr Ala Lys Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn Ser 
        595                 600                 605             


Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile Gln 
    610                 615                 620                 


Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg Leu His Lys Gln Gly Ile 
625                 630                 635                 640 


Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro Gly Ala Gln Pro Pro Val 
                645                 650                 655     


Ile Pro Gln Ala Gln Pro Val Arg Pro Pro Asn Gly Pro Leu Ser Leu 
            660                 665                 670         


Pro Val Asn Arg Met Gln Val Ser Gln Gly Met Asn Ser Phe Asn Pro 
        675                 680                 685             


Met Ser Leu Gly Asn Val Gln Leu Pro Gln Ala Pro Met Gly Pro Arg 
    690                 695                 700                 


Ala Ala Ser Pro Met Asn His Ser Val Gln Met Asn Ser Met Gly Ser 
705                 710                 715                 720 


Val Pro Gly Met Ala Ile Ser Pro Ser Arg Met Pro Gln Pro Pro Asn 
                725                 730                 735     


Met Met Gly Ala His Xaa Asn Asn Met Met Ala Gln Ala Pro Ala Gln 
            740                 745                 750         


Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro Ser Ser Ser Gly Ala Met 
        755                 760                 765             


Ser Val Gly Met Gly Gln Pro Pro Ala Gln Xaa Gly Val Ser Gln Gly 
    770                 775                 780                 


Gln Val Pro Gly Ala Ala Leu Pro Asn Pro Leu Asn Met Leu Gly Pro 
785                 790                 795                 800 


Gln Ala Ser Gln Leu Pro Cys Pro Pro Val Xaa Gln Ser Pro Leu His 
                805                 810                 815     


Pro Xaa Pro Pro Pro Ala Ser Xaa Ala Ala Gly Met Pro Ser Leu Gln 
            820                 825                 830         


His Xaa Xaa Pro Pro Gly Met Xaa Pro Pro Gln Pro Ala Ala Pro Xaa 
        835                 840                 845             


Gln Pro Ser Xaa Pro Val Ser Ser Ser Gly Gln Xaa Pro Xaa Pro Xaa 
    850                 855                 860                 


Pro Gly Ser Val Pro Ser Ala Xaa Gln Xaa Gln Ser Xaa Pro Xaa Val 
865                 870                 875                 880 


Gln Ala Ala Ala Gln Ala Gln Val Xaa Pro Gln Pro Gln Xaa Pro Val 
                885                 890                 895     


Gln Pro Pro Ser Val Ala Xaa Pro Gln Ser Ser Gln Gln Gln Pro Xaa 
            900                 905                 910         


Pro Val His Ala Gln Pro Pro Gly Xaa Pro Leu Ser Gln Ala Ala Ala 
        915                 920                 925             


Ser Ile Asp Asn Arg Val Pro Xaa Pro Ser Ser Val Ala Ser Ala Glu 
    930                 935                 940                 


Xaa Asn Ser Gln Gln Pro Gly Pro Asp Val Pro Val Leu Glu Met Lys 
945                 950                 955                 960 


Xaa Glu Xaa Gln Ala Glu Asp Xaa Glu Pro Asp Pro Gly Glu Ser Lys 
                965                 970                 975     


Gly Glu Pro Arg Ser Glu Met Met Glu Glu Asp Leu Gln Gly Ala Ser 
            980                 985                 990         


Gln Val Lys Glu Glu Xaa Asp Ile  Ala Glu Gln Lys Ser  Glu Pro Met 
        995                 1000                 1005             


Glu Val  Asp Glu Lys Lys Pro  Glu Val Lys Val Glu  Val Lys Glu 
    1010                 1015                 1020             


Glu Glu  Glu Ser Ser Ser Asn  Gly Xaa Ala Ser Gln  Ser Xaa Ser 
    1025                 1030                 1035             


Pro Ser  Gln Pro Arg Lys Lys  Ile Phe Lys Pro Glu  Glu Leu Arg 
    1040                 1045                 1050             


Gln Ala  Leu Met Pro Xaa Leu  Glu Ala Leu Tyr Arg  Gln Asp Pro 
    1055                 1060                 1065             


Glu Ser  Leu Pro Phe Arg Gln  Pro Val Asp Pro Gln  Leu Leu Gly 
    1070                 1075                 1080             


Ile Pro  Asp Tyr Phe Asp Ile  Val Lys Asn Pro Met  Asp Leu Ser 
    1085                 1090                 1095             


Xaa Ile  Lys Arg Lys Leu Asp  Xaa Gly Gln Tyr Gln  Glu Pro Trp 
    1100                 1105                 1110             


Gln Tyr  Val Asp Asp Val Trp  Leu Met Phe Asn Asn  Ala Trp Leu 
    1115                 1120                 1125             


Tyr Asn  Arg Lys Xaa Ser Arg  Val Tyr Lys Phe Cys  Ser Lys Leu 
    1130                 1135                 1140             


Ala Glu  Val Phe Glu Gln Glu  Ile Asp Pro Val Met  Gln Ser Leu 
    1145                 1150                 1155             


Gly Tyr  Cys Cys Gly Arg Lys  Tyr Glu Phe Ser Pro  Gln Xaa Leu 
    1160                 1165                 1170             


Cys Cys  Tyr Gly Lys Gln Leu  Cys Xaa Ile Pro Arg  Asp Ala Ala 
    1175                 1180                 1185             


Tyr Tyr  Ser Tyr Gln Asn Arg  Tyr His Phe Cys Glu  Lys Cys Phe 
    1190                 1195                 1200             


Xaa Glu  Ile Gln Gly Glu Asn  Val Xaa Leu Gly Asp  Asp Pro Ser 
    1205                 1210                 1215             


Gln Pro  Gln Xaa Xaa Ile Ser  Lys Asp Gln Phe Glu  Lys Lys Lys 
    1220                 1225                 1230             


Asn Asp  Xaa Leu Asp Pro Glu  Pro Phe Val Asp Cys  Lys Glu Cys 
    1235                 1240                 1245             


Gly Arg  Lys Met His Gln Ile  Cys Val Leu His Tyr  Asp Ile Ile 
    1250                 1255                 1260             


Trp Pro  Ser Gly Phe Val Cys  Asp Asn Cys Leu Lys  Lys Xaa Gly 
    1265                 1270                 1275             


Arg Pro  Arg Lys Glu Asn Lys  Phe Ser Ala Lys Arg  Leu Gln Xaa 
    1280                 1285                 1290             


Xaa Arg  Leu Gly Asn His Leu  Glu Asp Arg Val Asn  Lys Phe Leu 
    1295                 1300                 1305             


Arg Arg  Gln Asn His Pro Glu  Ala Gly Glu Val Phe  Val Arg Val 
    1310                 1315                 1320             


Val Ala  Ser Ser Asp Lys Xaa  Val Glu Val Lys Pro  Gly Met Lys 
    1325                 1330                 1335             


Ser Arg  Phe Val Asp Ser Gly  Glu Met Ser Glu Ser  Phe Pro Tyr 
    1340                 1345                 1350             


Arg Xaa  Lys Ala Leu Phe Ala  Phe Glu Glu Ile Asp  Gly Val Asp 
    1355                 1360                 1365             


Val Cys  Phe Phe Gly Met His  Val Gln Glu Tyr Gly  Ser Asp Cys 
    1370                 1375                 1380             


Pro Pro  Pro Asn Xaa Arg Arg  Val Tyr Ile Ser Tyr  Leu Asp Ser 
    1385                 1390                 1395             


Ile His  Phe Phe Arg Pro Arg  Cys Leu Arg Xaa Ala  Val Tyr His 
    1400                 1405                 1410             


Glu Ile  Leu Ile Gly Tyr Leu  Glu Tyr Val Lys Lys  Leu Gly Tyr 
    1415                 1420                 1425             


Val Xaa  Gly His Ile Trp Ala  Cys Pro Pro Ser Glu  Gly Asp Asp 
    1430                 1435                 1440             


Tyr Ile  Phe His Cys His Pro  Pro Asp Gln Lys Ile  Pro Lys Pro 
    1445                 1450                 1455             


Lys Arg  Leu Gln Glu Trp Tyr  Lys Lys Met Leu Asp  Lys Ala Phe 
    1460                 1465                 1470             


Ala Glu  Arg Ile Ile His Asp  Tyr Lys Asp Ile Phe  Lys Gln Ala 
    1475                 1480                 1485             


Xaa Glu  Asp Arg Leu Xaa Ser  Ala Lys Glu Leu Pro  Tyr Phe Glu 
    1490                 1495                 1500             


Gly Asp  Phe Trp Pro Asn Val  Leu Glu Glu Ser Ile  Lys Glu Leu 
    1505                 1510                 1515             


Glu Gln  Glu Glu Glu Glu Arg  Lys Lys Glu Glu Ser  Xaa Ala Ala 
    1520                 1525                 1530             


Ser Glu  Xaa Xaa Glu Gly Ser  Gln Gly Asp Ser Lys  Asn Ala Lys 
    1535                 1540                 1545             


Lys Lys  Asn Asn Lys Lys Xaa  Asn Lys Asn Lys Ser  Ser Ile Ser 
    1550                 1555                 1560             


Arg Ala  Asn Lys Lys Lys Pro  Ser Met Pro Asn Val  Ser Asn Asp 
    1565                 1570                 1575             


Leu Ser  Gln Lys Leu Tyr Ala  Xaa Met Glu Lys His  Lys Glu Val 
    1580                 1585                 1590             


Phe Phe  Val Ile His Leu His  Ala Gly Pro Val Ile  Asn Xaa Leu 
    1595                 1600                 1605             


Pro Pro  Ile Val Asp Pro Asp  Pro Leu Leu Ser Cys  Asp Leu Met 
    1610                 1615                 1620             


Asp Gly  Arg Asp Ala Phe Leu  Xaa Leu Ala Arg Asp  Lys His Trp 
    1625                 1630                 1635             


Glu Phe  Ser Ser Leu Arg Arg  Ser Lys Trp Ser Xaa  Leu Cys Met 
    1640                 1645                 1650             


Leu Val  Glu Leu His Xaa Gln  Gly Gln Asp Arg Phe  Val Tyr Xaa 
    1655                 1660                 1665             


Cys Asn  Glu Cys Lys His His  Val Glu Xaa Arg Trp  His Cys Xaa 
    1670                 1675                 1680             


Val Cys  Glu Asp Tyr Asp Leu  Cys Ile Asn Cys Tyr  Asn Xaa Lys 
    1685                 1690                 1695             


Ser His  Ala His Lys Met Val  Lys Trp Gly Leu Gly  Leu Asp Asp 
    1700                 1705                 1710             


Glu Gly  Ser Ser Gln Gly Glu  Pro Gln Ser Lys Ser  Pro Gln Glu 
    1715                 1720                 1725             


Ser Arg  Arg Leu Ser Ile Gln  Arg Cys Ile Gln Ser  Leu Val His 
    1730                 1735                 1740             


Ala Cys  Gln Cys Arg Asn Ala  Asn Cys Ser Leu Pro  Ser Cys Gln 
    1745                 1750                 1755             


Lys Met  Lys Arg Val Val Gln  His Xaa Lys Gly Cys  Lys Arg Lys 
    1760                 1765                 1770             


Xaa Asn  Gly Gly Cys Pro Val  Cys Lys Gln Leu Ile  Ala Leu Cys 
    1775                 1780                 1785             


Cys Tyr  His Ala Lys His Cys  Gln Glu Asn Lys Cys  Pro Val Pro 
    1790                 1795                 1800             


Phe Cys  Leu Asn Ile Lys His  Lys Leu Arg Gln Gln  Gln Ile Gln 
    1805                 1810                 1815             


His Arg  Leu Gln Gln Ala Gln  Leu Met Arg Arg Arg  Met Ala Xaa 
    1820                 1825                 1830             


Met Asn  Xaa Arg Asn Val Pro  Gln Gln Ser Leu Pro  Ser Pro Xaa 
    1835                 1840                 1845             


Ser Ala  Pro Pro Gly Xaa Pro  Xaa Gln Gln Pro Ser  Xaa Pro Gln 
    1850                 1855                 1860             


Xaa Pro  Gln Pro Pro Ala Gln  Pro Gln Pro Ser Pro  Val Ser Met 
    1865                 1870                 1875             


Ser Pro  Ala Gly Phe Pro Ser  Val Ala Arg Xaa Gln  Pro Pro Xaa 
    1880                 1885                 1890             


Xaa Val  Ser Xaa Gly Lys Pro  Xaa Ser Gln Val Pro  Ala Pro Pro 
    1895                 1900                 1905             


Pro Pro  Ala Gln Pro Pro Pro  Ala Ala Val Glu Ala  Ala Arg Gln 
    1910                 1915                 1920             


Ile Glu  Arg Glu Ala Gln Gln  Gln Gln His Leu Tyr  Arg Val Asn 
    1925                 1930                 1935             


Ile Asn  Asn Ser Met Pro Pro  Gly Arg Xaa Gly Met  Gly Xaa Pro 
    1940                 1945                 1950             


Gly Ser  Gln Met Ala Pro Val  Ser Leu Asn Val Pro  Arg Pro Asn 
    1955                 1960                 1965             


Gln Val  Ser Gly Pro Val Met  Pro Ser Met Pro Pro  Gly Gln Trp 
    1970                 1975                 1980             


Gln Gln  Ala Pro Leu Pro Gln  Gln Gln Pro Met Pro  Gly Leu Pro 
    1985                 1990                 1995             


Arg Pro  Val Ile Ser Met Gln  Ala Gln Ala Ala Val  Ala Gly Pro 
    2000                 2005                 2010             


Arg Met  Pro Ser Val Gln Pro  Pro Arg Ser Ile Ser  Pro Ser Ala 
    2015                 2020                 2025             


Leu Gln  Asp Leu Leu Arg Xaa  Leu Lys Ser Pro Ser  Ser Pro Gln 
    2030                 2035                 2040             


Gln Gln  Gln Gln Val Leu Asn  Ile Leu Lys Ser Asn  Pro Gln Leu 
    2045                 2050                 2055             


Met Ala  Ala Phe Ile Lys Gln  Arg Xaa Ala Lys Tyr  Val Ala Asn 
    2060                 2065                 2070             


Gln Pro  Gly Met Gln Pro Gln  Pro Gly Leu Gln Ser  Gln Pro Gly 
    2075                 2080                 2085             


Met Gln  Pro Gln Pro Gly Met  His Gln Gln Pro Ser  Leu Gln Asn 
    2090                 2095                 2100             


Leu Asn  Ala Met Gln Ala Gly  Val Pro Arg Pro Gly  Val Pro Pro 
    2105                 2110                 2115             


Gln Gln  Gln Ala Met Gly Gly  Leu Asn Pro Gln Gly  Gln Ala Leu 
    2120                 2125                 2130             


Asn Ile  Met Asn Pro Gly His  Asn Pro Asn Met Ala  Ser Met Asn 
    2135                 2140                 2145             


Pro Gln  Tyr Arg Glu Met Leu  Arg Arg Gln Leu Leu  Gln Gln Gln 
    2150                 2155                 2160             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2165                 2170                 2175             


Gly Ser  Ala Gly Met Ala Gly  Gly Met Ala Gly His  Gly Gln Phe 
    2180                 2185                 2190             


Gln Gln  Pro Gln Gly Pro Gly  Gly Tyr Pro Pro Ala  Met Gln Gln 
    2195                 2200                 2205             


Gln Gln  Arg Met Gln Gln His  Leu Pro Leu Gln Gly  Ser Ser Met 
    2210                 2215                 2220             


Gly Gln  Met Ala Ala Gln Met  Gly Gln Leu Gly Gln  Met Gly Gln 
    2225                 2230                 2235             


Pro Gly  Leu Gly Ala Asp Ser  Xaa Pro Asn Ile Gln  Gln Ala Leu 
    2240                 2245                 2250             


Gln Gln  Arg Ile Leu Gln Gln  Gln Gln Met Lys Gln  Gln Ile Gly 
    2255                 2260                 2265             


Ser Pro  Gly Gln Pro Asn Pro  Met Ser Pro Gln Gln  His Met Leu 
    2270                 2275                 2280             


Ser Gly  Gln Pro Gln Ala Ser  His Leu Pro Gly Gln  Gln Ile Ala 
    2285                 2290                 2295             


Xaa Ser  Leu Ser Asn Gln Val  Arg Ser Pro Ala Pro  Val Gln Ser 
    2300                 2305                 2310             


Pro Arg  Pro Gln Ser Gln Pro  Pro His Ser Ser Pro  Ser Pro Arg 
    2315                 2320                 2325             


Ile Gln  Pro Gln Pro Ser Pro  His His Val Ser Pro  Gln Xaa Gly 
    2330                 2335                 2340             


Ser Pro  His Pro Gly Leu Ala  Val Xaa Met Ala Ser  Ser Ile Asp 
    2345                 2350                 2355             


Gln Gly  His Leu Gly Asn Pro  Glu Gln Ser Ala Met  Leu Pro Gln 
    2360                 2365                 2370             


Leu Asn  Xaa Pro Ser Arg Ser  Ala Leu Ser Ser Glu  Leu Ser Leu 
    2375                 2380                 2385             


Val Gly  Asp Xaa Xaa Gly Asp  Xaa Leu Glu Lys Phe  Val Glu Gly 
    2390                 2395                 2400             


Leu 
    


<210> 6891
<211> 2442
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(873)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (983)..(983)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1001)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1070)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1260)..(1261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1274)..(1274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1315)..(1315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1331)..(1332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1368)..(1368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1393)..(1393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1426)..(1426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1447)..(1447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1468)..(1468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1527)..(1527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1532)..(1532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1569)..(1569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1574)..(1575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1593)..(1593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1624)..(1624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1645)..(1645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1669)..(1669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1688)..(1688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1697)..(1697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1706)..(1706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1716)..(1716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1721)..(1721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1735)..(1735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1805)..(1805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1812)..(1812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1871)..(1871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1874)..(1874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1886)..(1886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1892)..(1892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1894)..(1894)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1899)..(1899)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1902)..(1902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1927)..(1927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1931)..(1932)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1935)..(1935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1939)..(1939)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1986)..(1986)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1990)..(1990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2073)..(2073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2105)..(2105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2284)..(2284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2337)..(2337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2380)..(2380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2390)..(2390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2414)..(2414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2430)..(2431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2434)..(2434)
<223> Selenocysteine

<400> 6891
Met Ala Glu Asn Leu Leu Asp Gly Pro Pro Asn Pro Lys Arg Ala Lys 
1               5                   10                  15      


Leu Ser Ser Pro Gly Phe Ser Ala Asn Asp Ser Xaa Asp Phe Gly Ser 
            20                  25                  30          


Leu Phe Asp Leu Glu Asn Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly 
        35                  40                  45              


Gly Glu Leu Gly Leu Leu Asn Ser Gly Asn Leu Val Pro Asp Ala Ala 
    50                  55                  60                  


Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser 
65                  70                  75                  80  


Ser Ile Asn Pro Gly Ile Gly Asn Val Ser Ala Ser Ser Pro Val Gln 
                85                  90                  95      


Gln Gly Leu Gly Gly Gln Ala Gln Gly Gln Pro Asn Ser Ala Asn Met 
            100                 105                 110         


Ala Ser Leu Ser Ala Met Gly Lys Ser Pro Leu Ser Gln Gly Asp Ser 
        115                 120                 125             


Ser Ala Pro Ser Leu Pro Lys Gln Ala Ala Ser Xaa Ser Gly Pro Xaa 
    130                 135                 140                 


Pro Ala Ala Ser Gln Ala Leu Asn Pro Gln Ala Gln Lys Gln Val Gly 
145                 150                 155                 160 


Leu Ala Xaa Ser Ser Pro Ala Xaa Ser Gln Xaa Gly Pro Gly Ile Cys 
                165                 170                 175     


Met Asn Ala Asn Phe Asn Gln Xaa His Pro Gly Leu Leu Asn Ser Asn 
            180                 185                 190         


Ser Gly His Ser Leu Ile Asn Gln Ala Ser Gln Gly Gln Ala Gln Val 
        195                 200                 205             


Met Asn Gly Ser Leu Gly Ala Ala Gly Arg Gly Arg Gly Ala Gly Met 
    210                 215                 220                 


Pro Tyr Pro Xaa Pro Ala Met Gln Gly Ala Ser Ser Ser Val Leu Ala 
225                 230                 235                 240 


Glu Xaa Leu Xaa Gln Val Ser Pro Gln Met Xaa Gly His Ala Gly Leu 
                245                 250                 255     


Asn Xaa Ala Gln Ala Gly Gly Met Ala Lys Met Gly Ile Xaa Gly Asn 
            260                 265                 270         


Xaa Ser Pro Phe Gly Gln Pro Phe Ser Gln Ala Gly Gly Gln Pro Met 
        275                 280                 285             


Gly Ala Xaa Gly Val Asn Pro Gln Leu Ala Ser Lys Gln Ser Met Val 
    290                 295                 300                 


Asn Ser Leu Pro Xaa Phe Pro Xaa Asp Ile Lys Asn Xaa Ser Val Xaa 
305                 310                 315                 320 


Asn Val Pro Asn Met Ser Gln Met Gln Xaa Ser Val Gly Ile Val Pro 
                325                 330                 335     


Xaa Gln Ala Ile Ala Xaa Gly Pro Xaa Ala Asp Pro Glu Lys Arg Lys 
            340                 345                 350         


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
        355                 360                 365             


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Ala Cys Ser Leu Pro His 
    370                 375                 380                 


Cys Arg Xaa Met Lys Asn Val Leu Asn His Met Xaa His Cys Gln Ala 
385                 390                 395                 400 


Gly Lys Ala Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile 
                405                 410                 415     


Ser His Trp Lys Asn Cys Xaa Arg His Asp Cys Pro Val Cys Leu Pro 
            420                 425                 430         


Leu Lys Asn Ala Ser Asp Lys Arg Asn Gln Gln Xaa Ile Leu Gly Ser 
        435                 440                 445             


Pro Ala Ser Gly Ile Gln Asn Xaa Ile Gly Ser Val Gly Xaa Gly Gln 
    450                 455                 460                 


Gln Asn Ala Xaa Ser Leu Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser 
465                 470                 475                 480 


Met Gln Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro 
                485                 490                 495     


Gln Xaa Gln Leu Gln Pro Gln Val Pro Gly Gln Gln Pro Ala Gln Pro 
            500                 505                 510         


Gln Xaa His Gln Gln Met Arg Xaa Leu Asn Pro Leu Gly Asn Asn Pro 
        515                 520                 525             


Met Asn Ile Pro Ala Gly Gly Ile Xaa Xaa Asp Gln Gln Pro Pro Asn 
    530                 535                 540                 


Leu Ile Ser Glu Ser Ala Leu Pro Xaa Ser Leu Gly Ala Xaa Asn Pro 
545                 550                 555                 560 


Leu Met Asn Asp Gly Ser Asn Ser Gly Asn Ile Gly Xaa Leu Ser Xaa 
                565                 570                 575     


Ile Pro Xaa Ala Ala Pro Pro Ser Ser Xaa Gly Val Arg Lys Gly Trp 
            580                 585                 590         


His Glu His Val Xaa Gln Asp Leu Arg Ser His Leu Val His Lys Leu 
        595                 600                 605             


Val Gln Ala Ile Phe Pro Xaa Pro Asp Pro Ala Ala Leu Lys Asp Arg 
    610                 615                 620                 


Arg Met Glu Asn Leu Val Ala Tyr Ala Lys Lys Val Glu Gly Asp Met 
625                 630                 635                 640 


Tyr Glu Ser Ala Asn Ser Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu 
                645                 650                 655     


Lys Ile Tyr Lys Ile Gln Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg 
            660                 665                 670         


Leu His Lys Gln Gly Ile Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro 
        675                 680                 685             


Gly Ala Gln Pro Pro Val Ile Pro Gln Ala Gln Pro Val Arg Pro Pro 
    690                 695                 700                 


Asn Gly Pro Leu Ser Leu Pro Val Asn Arg Met Gln Val Ser Gln Gly 
705                 710                 715                 720 


Met Asn Ser Phe Asn Pro Met Ser Leu Gly Asn Val Gln Leu Pro Gln 
                725                 730                 735     


Ala Pro Met Gly Pro Arg Ala Ala Ser Pro Met Asn His Ser Val Gln 
            740                 745                 750         


Met Asn Ser Met Gly Ser Val Pro Gly Met Ala Ile Ser Pro Ser Arg 
        755                 760                 765             


Met Pro Gln Pro Pro Asn Met Met Gly Ala His Xaa Asn Asn Met Met 
    770                 775                 780                 


Ala Gln Ala Pro Ala Gln Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro 
785                 790                 795                 800 


Ser Ser Ser Gly Ala Met Ser Val Gly Met Gly Gln Pro Pro Ala Gln 
                805                 810                 815     


Xaa Gly Val Ser Gln Gly Gln Val Pro Gly Ala Ala Leu Pro Asn Pro 
            820                 825                 830         


Leu Asn Met Leu Gly Pro Gln Ala Ser Gln Leu Pro Cys Pro Pro Val 
        835                 840                 845             


Xaa Gln Ser Pro Leu His Pro Xaa Pro Pro Pro Ala Ser Xaa Ala Ala 
    850                 855                 860                 


Gly Met Pro Ser Leu Gln His Xaa Xaa Pro Pro Gly Met Xaa Pro Pro 
865                 870                 875                 880 


Gln Pro Ala Ala Pro Xaa Gln Pro Ser Xaa Pro Val Ser Ser Ser Gly 
                885                 890                 895     


Gln Xaa Pro Xaa Pro Xaa Pro Gly Ser Val Pro Ser Ala Xaa Gln Xaa 
            900                 905                 910         


Gln Ser Xaa Pro Xaa Val Gln Ala Ala Ala Gln Ala Gln Val Xaa Pro 
        915                 920                 925             


Gln Pro Gln Xaa Pro Val Gln Pro Pro Ser Val Ala Xaa Pro Gln Ser 
    930                 935                 940                 


Ser Gln Gln Gln Pro Xaa Pro Val His Ala Gln Pro Pro Gly Xaa Pro 
945                 950                 955                 960 


Leu Ser Gln Ala Ala Ala Ser Ile Asp Asn Arg Val Pro Xaa Pro Ser 
                965                 970                 975     


Ser Val Ala Ser Ala Glu Xaa Asn Ser Gln Gln Pro Gly Pro Asp Val 
            980                 985                 990         


Pro Val Leu Glu Met Lys Xaa Glu  Xaa Gln Ala Glu Asp  Xaa Glu Pro 
        995                 1000                 1005             


Asp Pro  Gly Glu Ser Lys Gly  Glu Pro Arg Ser Glu  Met Met Glu 
    1010                 1015                 1020             


Glu Asp  Leu Gln Gly Ala Ser  Gln Val Lys Glu Glu  Xaa Asp Ile 
    1025                 1030                 1035             


Ala Glu  Gln Lys Ser Glu Pro  Met Glu Val Asp Glu  Lys Lys Pro 
    1040                 1045                 1050             


Glu Val  Lys Val Glu Val Lys  Glu Glu Glu Glu Ser  Ser Ser Asn 
    1055                 1060                 1065             


Gly Xaa  Ala Ser Gln Ser Xaa  Ser Pro Ser Gln Pro  Arg Lys Lys 
    1070                 1075                 1080             


Ile Phe  Lys Pro Glu Glu Leu  Arg Gln Ala Leu Met  Pro Xaa Leu 
    1085                 1090                 1095             


Glu Ala  Leu Tyr Arg Gln Asp  Pro Glu Ser Leu Pro  Phe Arg Gln 
    1100                 1105                 1110             


Pro Val  Asp Pro Gln Leu Leu  Gly Ile Pro Asp Tyr  Phe Asp Ile 
    1115                 1120                 1125             


Val Lys  Asn Pro Met Asp Leu  Ser Xaa Ile Lys Arg  Lys Leu Asp 
    1130                 1135                 1140             


Xaa Gly  Gln Tyr Gln Glu Pro  Trp Gln Tyr Val Asp  Asp Val Trp 
    1145                 1150                 1155             


Leu Met  Phe Asn Asn Ala Trp  Leu Tyr Asn Arg Lys  Xaa Ser Arg 
    1160                 1165                 1170             


Val Tyr  Lys Phe Cys Ser Lys  Leu Ala Glu Val Phe  Glu Gln Glu 
    1175                 1180                 1185             


Ile Asp  Pro Val Met Gln Ser  Leu Gly Tyr Cys Cys  Gly Arg Lys 
    1190                 1195                 1200             


Tyr Glu  Phe Ser Pro Gln Xaa  Leu Cys Cys Tyr Gly  Lys Gln Leu 
    1205                 1210                 1215             


Cys Xaa  Ile Pro Arg Asp Ala  Ala Tyr Tyr Ser Tyr  Gln Asn Arg 
    1220                 1225                 1230             


Tyr His  Phe Cys Glu Lys Cys  Phe Xaa Glu Ile Gln  Gly Glu Asn 
    1235                 1240                 1245             


Val Xaa  Leu Gly Asp Asp Pro  Ser Gln Pro Gln Xaa  Xaa Ile Ser 
    1250                 1255                 1260             


Lys Asp  Gln Phe Glu Lys Lys  Lys Asn Asp Xaa Leu  Asp Pro Glu 
    1265                 1270                 1275             


Pro Phe  Val Asp Cys Lys Glu  Cys Gly Arg Lys Met  His Gln Ile 
    1280                 1285                 1290             


Cys Val  Leu His Tyr Asp Ile  Ile Trp Pro Ser Gly  Phe Val Cys 
    1295                 1300                 1305             


Asp Asn  Cys Leu Lys Lys Xaa  Gly Arg Pro Arg Lys  Glu Asn Lys 
    1310                 1315                 1320             


Phe Ser  Ala Lys Arg Leu Gln  Xaa Xaa Arg Leu Gly  Asn His Leu 
    1325                 1330                 1335             


Glu Asp  Arg Val Asn Lys Phe  Leu Arg Arg Gln Asn  His Pro Glu 
    1340                 1345                 1350             


Ala Gly  Glu Val Phe Val Arg  Val Val Ala Ser Ser  Asp Lys Xaa 
    1355                 1360                 1365             


Val Glu  Val Lys Pro Gly Met  Lys Ser Arg Phe Val  Asp Ser Gly 
    1370                 1375                 1380             


Glu Met  Ser Glu Ser Phe Pro  Tyr Arg Xaa Lys Ala  Leu Phe Ala 
    1385                 1390                 1395             


Phe Glu  Glu Ile Asp Gly Val  Asp Val Cys Phe Phe  Gly Met His 
    1400                 1405                 1410             


Val Gln  Glu Tyr Gly Ser Asp  Cys Pro Pro Pro Asn  Xaa Arg Arg 
    1415                 1420                 1425             


Val Tyr  Ile Ser Tyr Leu Asp  Ser Ile His Phe Phe  Arg Pro Arg 
    1430                 1435                 1440             


Cys Leu  Arg Xaa Ala Val Tyr  His Glu Ile Leu Ile  Gly Tyr Leu 
    1445                 1450                 1455             


Glu Tyr  Val Lys Lys Leu Gly  Tyr Val Xaa Gly His  Ile Trp Ala 
    1460                 1465                 1470             


Cys Pro  Pro Ser Glu Gly Asp  Asp Tyr Ile Phe His  Cys His Pro 
    1475                 1480                 1485             


Pro Asp  Gln Lys Ile Pro Lys  Pro Lys Arg Leu Gln  Glu Trp Tyr 
    1490                 1495                 1500             


Lys Lys  Met Leu Asp Lys Ala  Phe Ala Glu Arg Ile  Ile His Asp 
    1505                 1510                 1515             


Tyr Lys  Asp Ile Phe Lys Gln  Ala Xaa Glu Asp Arg  Leu Xaa Ser 
    1520                 1525                 1530             


Ala Lys  Glu Leu Pro Tyr Phe  Glu Gly Asp Phe Trp  Pro Asn Val 
    1535                 1540                 1545             


Leu Glu  Glu Ser Ile Lys Glu  Leu Glu Gln Glu Glu  Glu Glu Arg 
    1550                 1555                 1560             


Lys Lys  Glu Glu Ser Xaa Ala  Ala Ser Glu Xaa Xaa  Glu Gly Ser 
    1565                 1570                 1575             


Gln Gly  Asp Ser Lys Asn Ala  Lys Lys Lys Asn Asn  Lys Lys Xaa 
    1580                 1585                 1590             


Asn Lys  Asn Lys Ser Ser Ile  Ser Arg Ala Asn Lys  Lys Lys Pro 
    1595                 1600                 1605             


Ser Met  Pro Asn Val Ser Asn  Asp Leu Ser Gln Lys  Leu Tyr Ala 
    1610                 1615                 1620             


Xaa Met  Glu Lys His Lys Glu  Val Phe Phe Val Ile  His Leu His 
    1625                 1630                 1635             


Ala Gly  Pro Val Ile Asn Xaa  Leu Pro Pro Ile Val  Asp Pro Asp 
    1640                 1645                 1650             


Pro Leu  Leu Ser Cys Asp Leu  Met Asp Gly Arg Asp  Ala Phe Leu 
    1655                 1660                 1665             


Xaa Leu  Ala Arg Asp Lys His  Trp Glu Phe Ser Ser  Leu Arg Arg 
    1670                 1675                 1680             


Ser Lys  Trp Ser Xaa Leu Cys  Met Leu Val Glu Leu  His Xaa Gln 
    1685                 1690                 1695             


Gly Gln  Asp Arg Phe Val Tyr  Xaa Cys Asn Glu Cys  Lys His His 
    1700                 1705                 1710             


Val Glu  Xaa Arg Trp His Cys  Xaa Val Cys Glu Asp  Tyr Asp Leu 
    1715                 1720                 1725             


Cys Ile  Asn Cys Tyr Asn Xaa  Lys Ser His Ala His  Lys Met Val 
    1730                 1735                 1740             


Lys Trp  Gly Leu Gly Leu Asp  Asp Glu Gly Ser Ser  Gln Gly Glu 
    1745                 1750                 1755             


Pro Gln  Ser Lys Ser Pro Gln  Glu Ser Arg Arg Leu  Ser Ile Gln 
    1760                 1765                 1770             


Arg Cys  Ile Gln Ser Leu Val  His Ala Cys Gln Cys  Arg Asn Ala 
    1775                 1780                 1785             


Asn Cys  Ser Leu Pro Ser Cys  Gln Lys Met Lys Arg  Val Val Gln 
    1790                 1795                 1800             


His Xaa  Lys Gly Cys Lys Arg  Lys Xaa Asn Gly Gly  Cys Pro Val 
    1805                 1810                 1815             


Cys Lys  Gln Leu Ile Ala Leu  Cys Cys Tyr His Ala  Lys His Cys 
    1820                 1825                 1830             


Gln Glu  Asn Lys Cys Pro Val  Pro Phe Cys Leu Asn  Ile Lys His 
    1835                 1840                 1845             


Lys Leu  Arg Gln Gln Gln Ile  Gln His Arg Leu Gln  Gln Ala Gln 
    1850                 1855                 1860             


Leu Met  Arg Arg Arg Met Ala  Xaa Met Asn Xaa Arg  Asn Val Pro 
    1865                 1870                 1875             


Gln Gln  Ser Leu Pro Ser Pro  Xaa Ser Ala Pro Pro  Gly Xaa Pro 
    1880                 1885                 1890             


Xaa Gln  Gln Pro Ser Xaa Pro  Gln Xaa Pro Gln Pro  Pro Ala Gln 
    1895                 1900                 1905             


Pro Gln  Pro Ser Pro Val Ser  Met Ser Pro Ala Gly  Phe Pro Ser 
    1910                 1915                 1920             


Val Ala  Arg Xaa Gln Pro Pro  Xaa Xaa Val Ser Xaa  Gly Lys Pro 
    1925                 1930                 1935             


Xaa Ser  Gln Val Pro Ala Pro  Pro Pro Pro Ala Gln  Pro Pro Pro 
    1940                 1945                 1950             


Ala Ala  Val Glu Ala Ala Arg  Gln Ile Glu Arg Glu  Ala Gln Gln 
    1955                 1960                 1965             


Gln Gln  His Leu Tyr Arg Val  Asn Ile Asn Asn Ser  Met Pro Pro 
    1970                 1975                 1980             


Gly Arg  Xaa Gly Met Gly Xaa  Pro Gly Ser Gln Met  Ala Pro Val 
    1985                 1990                 1995             


Ser Leu  Asn Val Pro Arg Pro  Asn Gln Val Ser Gly  Pro Val Met 
    2000                 2005                 2010             


Pro Ser  Met Pro Pro Gly Gln  Trp Gln Gln Ala Pro  Leu Pro Gln 
    2015                 2020                 2025             


Gln Gln  Pro Met Pro Gly Leu  Pro Arg Pro Val Ile  Ser Met Gln 
    2030                 2035                 2040             


Ala Gln  Ala Ala Val Ala Gly  Pro Arg Met Pro Ser  Val Gln Pro 
    2045                 2050                 2055             


Pro Arg  Ser Ile Ser Pro Ser  Ala Leu Gln Asp Leu  Leu Arg Xaa 
    2060                 2065                 2070             


Leu Lys  Ser Pro Ser Ser Pro  Gln Gln Gln Gln Gln  Val Leu Asn 
    2075                 2080                 2085             


Ile Leu  Lys Ser Asn Pro Gln  Leu Met Ala Ala Phe  Ile Lys Gln 
    2090                 2095                 2100             


Arg Xaa  Ala Lys Tyr Val Ala  Asn Gln Pro Gly Met  Gln Pro Gln 
    2105                 2110                 2115             


Pro Gly  Leu Gln Ser Gln Pro  Gly Met Gln Pro Gln  Pro Gly Met 
    2120                 2125                 2130             


His Gln  Gln Pro Ser Leu Gln  Asn Leu Asn Ala Met  Gln Ala Gly 
    2135                 2140                 2145             


Val Pro  Arg Pro Gly Val Pro  Pro Gln Gln Gln Ala  Met Gly Gly 
    2150                 2155                 2160             


Leu Asn  Pro Gln Gly Gln Ala  Leu Asn Ile Met Asn  Pro Gly His 
    2165                 2170                 2175             


Asn Pro  Asn Met Ala Ser Met  Asn Pro Gln Tyr Arg  Glu Met Leu 
    2180                 2185                 2190             


Arg Arg  Gln Leu Leu Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2195                 2200                 2205             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gly Ser Ala Gly  Met Ala Gly 
    2210                 2215                 2220             


Gly Met  Ala Gly His Gly Gln  Phe Gln Gln Pro Gln  Gly Pro Gly 
    2225                 2230                 2235             


Gly Tyr  Pro Pro Ala Met Gln  Gln Gln Gln Arg Met  Gln Gln His 
    2240                 2245                 2250             


Leu Pro  Leu Gln Gly Ser Ser  Met Gly Gln Met Ala  Ala Gln Met 
    2255                 2260                 2265             


Gly Gln  Leu Gly Gln Met Gly  Gln Pro Gly Leu Gly  Ala Asp Ser 
    2270                 2275                 2280             


Xaa Pro  Asn Ile Gln Gln Ala  Leu Gln Gln Arg Ile  Leu Gln Gln 
    2285                 2290                 2295             


Gln Gln  Met Lys Gln Gln Ile  Gly Ser Pro Gly Gln  Pro Asn Pro 
    2300                 2305                 2310             


Met Ser  Pro Gln Gln His Met  Leu Ser Gly Gln Pro  Gln Ala Ser 
    2315                 2320                 2325             


His Leu  Pro Gly Gln Gln Ile  Ala Xaa Ser Leu Ser  Asn Gln Val 
    2330                 2335                 2340             


Arg Ser  Pro Ala Pro Val Gln  Ser Pro Arg Pro Gln  Ser Gln Pro 
    2345                 2350                 2355             


Pro His  Ser Ser Pro Ser Pro  Arg Ile Gln Pro Gln  Pro Ser Pro 
    2360                 2365                 2370             


His His  Val Ser Pro Gln Xaa  Gly Ser Pro His Pro  Gly Leu Ala 
    2375                 2380                 2385             


Val Xaa  Met Ala Ser Ser Ile  Asp Gln Gly His Leu  Gly Asn Pro 
    2390                 2395                 2400             


Glu Gln  Ser Ala Met Leu Pro  Gln Leu Asn Xaa Pro  Ser Arg Ser 
    2405                 2410                 2415             


Ala Leu  Ser Ser Glu Leu Ser  Leu Val Gly Asp Xaa  Xaa Gly Asp 
    2420                 2425                 2430             


Xaa Leu  Glu Lys Phe Val Glu  Gly Leu 
    2435                 2440         


<210> 6892
<211> 1105
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (938)..(938)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1013)..(1013)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Selenocysteine

<400> 6892
Asn Ala Xaa Ser Leu Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser Met 
1               5                   10                  15      


Gln Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro Gln 
            20                  25                  30          


Xaa Gln Leu Gln Pro Gln Val Pro Gly Gln Gln Pro Ala Gln Pro Gln 
        35                  40                  45              


Xaa His Gln Gln Met Arg Xaa Leu Asn Pro Leu Gly Asn Asn Pro Met 
    50                  55                  60                  


Asn Ile Pro Ala Gly Gly Ile Xaa Xaa Asp Gln Gln Pro Pro Asn Leu 
65                  70                  75                  80  


Ile Ser Glu Ser Ala Leu Pro Xaa Ser Leu Gly Ala Xaa Asn Pro Leu 
                85                  90                  95      


Met Asn Asp Gly Ser Asn Ser Gly Asn Ile Gly Xaa Leu Ser Xaa Ile 
            100                 105                 110         


Pro Xaa Ala Ala Pro Pro Ser Ser Xaa Gly Val Arg Lys Gly Trp His 
        115                 120                 125             


Glu His Val Xaa Gln Asp Leu Arg Ser His Leu Val His Lys Leu Val 
    130                 135                 140                 


Gln Ala Ile Phe Pro Xaa Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg 
145                 150                 155                 160 


Met Glu Asn Leu Val Ala Tyr Ala Lys Lys Val Glu Gly Asp Met Tyr 
                165                 170                 175     


Glu Ser Ala Asn Ser Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu Lys 
            180                 185                 190         


Ile Tyr Lys Ile Gln Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg Leu 
        195                 200                 205             


His Lys Gln Gly Ile Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro Gly 
    210                 215                 220                 


Ala Gln Pro Pro Val Ile Pro Gln Ala Gln Pro Val Arg Pro Pro Asn 
225                 230                 235                 240 


Gly Pro Leu Ser Leu Pro Val Asn Arg Met Gln Val Ser Gln Gly Met 
                245                 250                 255     


Asn Ser Phe Asn Pro Met Ser Leu Gly Asn Val Gln Leu Pro Gln Ala 
            260                 265                 270         


Pro Met Gly Pro Arg Ala Ala Ser Pro Met Asn His Ser Val Gln Met 
        275                 280                 285             


Asn Ser Met Gly Ser Val Pro Gly Met Ala Ile Ser Pro Ser Arg Met 
    290                 295                 300                 


Pro Gln Pro Pro Asn Met Met Gly Ala His Xaa Asn Asn Met Met Ala 
305                 310                 315                 320 


Gln Ala Pro Ala Gln Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro Ser 
                325                 330                 335     


Ser Ser Gly Ala Met Ser Val Gly Met Gly Gln Pro Pro Ala Gln Xaa 
            340                 345                 350         


Gly Val Ser Gln Gly Gln Val Pro Gly Ala Ala Leu Pro Asn Pro Leu 
        355                 360                 365             


Asn Met Leu Gly Pro Gln Ala Ser Gln Leu Pro Cys Pro Pro Val Xaa 
    370                 375                 380                 


Gln Ser Pro Leu His Pro Xaa Pro Pro Pro Ala Ser Xaa Ala Ala Gly 
385                 390                 395                 400 


Met Pro Ser Leu Gln His Xaa Xaa Pro Pro Gly Met Xaa Pro Pro Gln 
                405                 410                 415     


Pro Ala Ala Pro Xaa Gln Pro Ser Xaa Pro Val Ser Ser Ser Gly Gln 
            420                 425                 430         


Xaa Pro Xaa Pro Xaa Pro Gly Ser Val Pro Ser Ala Xaa Gln Xaa Gln 
        435                 440                 445             


Ser Xaa Pro Xaa Val Gln Ala Ala Ala Gln Ala Gln Val Xaa Pro Gln 
    450                 455                 460                 


Pro Gln Xaa Pro Val Gln Pro Pro Ser Val Ala Xaa Pro Gln Ser Ser 
465                 470                 475                 480 


Gln Gln Gln Pro Xaa Pro Val His Ala Gln Pro Pro Gly Xaa Pro Leu 
                485                 490                 495     


Ser Gln Ala Ala Ala Ser Ile Asp Asn Arg Val Pro Xaa Pro Ser Ser 
            500                 505                 510         


Val Ala Ser Ala Glu Xaa Asn Ser Gln Gln Pro Gly Pro Asp Val Pro 
        515                 520                 525             


Val Leu Glu Met Lys Xaa Glu Xaa Gln Ala Glu Asp Xaa Glu Pro Asp 
    530                 535                 540                 


Pro Gly Glu Ser Lys Gly Glu Pro Arg Ser Glu Met Met Glu Glu Asp 
545                 550                 555                 560 


Leu Gln Gly Ala Ser Gln Val Lys Glu Glu Xaa Asp Ile Ala Glu Gln 
                565                 570                 575     


Lys Ser Glu Pro Met Glu Val Asp Glu Lys Lys Pro Glu Val Lys Val 
            580                 585                 590         


Glu Val Lys Glu Glu Glu Glu Ser Ser Ser Asn Gly Xaa Ala Ser Gln 
        595                 600                 605             


Ser Xaa Ser Pro Ser Gln Pro Arg Lys Lys Ile Phe Lys Pro Glu Glu 
    610                 615                 620                 


Leu Arg Gln Ala Leu Met Pro Xaa Leu Glu Ala Leu Tyr Arg Gln Asp 
625                 630                 635                 640 


Pro Glu Ser Leu Pro Phe Arg Gln Pro Val Asp Pro Gln Leu Leu Gly 
                645                 650                 655     


Ile Pro Asp Tyr Phe Asp Ile Val Lys Asn Pro Met Asp Leu Ser Xaa 
            660                 665                 670         


Ile Lys Arg Lys Leu Asp Xaa Gly Gln Tyr Gln Glu Pro Trp Gln Tyr 
        675                 680                 685             


Val Asp Asp Val Trp Leu Met Phe Asn Asn Ala Trp Leu Tyr Asn Arg 
    690                 695                 700                 


Lys Xaa Ser Arg Val Tyr Lys Phe Cys Ser Lys Leu Ala Glu Val Phe 
705                 710                 715                 720 


Glu Gln Glu Ile Asp Pro Val Met Gln Ser Leu Gly Tyr Cys Cys Gly 
                725                 730                 735     


Arg Lys Tyr Glu Phe Ser Pro Gln Xaa Leu Cys Cys Tyr Gly Lys Gln 
            740                 745                 750         


Leu Cys Xaa Ile Pro Arg Asp Ala Ala Tyr Tyr Ser Tyr Gln Asn Ser 
        755                 760                 765             


Ser Pro Lys Tyr Gly Leu Leu Ala Asp Arg Tyr His Phe Cys Glu Lys 
    770                 775                 780                 


Cys Phe Xaa Glu Ile Gln Gly Glu Asn Val Xaa Leu Gly Asp Asp Pro 
785                 790                 795                 800 


Ser Gln Pro Gln Xaa Xaa Ile Ser Lys Asp Gln Phe Glu Lys Lys Lys 
                805                 810                 815     


Asn Asp Xaa Leu Asp Pro Glu Pro Phe Val Asp Cys Lys Glu Cys Gly 
            820                 825                 830         


Arg Lys Met His Gln Ile Cys Val Leu His Tyr Asp Ile Ile Trp Pro 
        835                 840                 845             


Ser Gly Phe Val Cys Asp Asn Cys Leu Lys Lys Xaa Gly Arg Pro Arg 
    850                 855                 860                 


Lys Glu Asn Lys Phe Ser Ala Lys Arg Leu Gln Xaa Xaa Arg Leu Gly 
865                 870                 875                 880 


Asn His Leu Glu Asp Arg Val Asn Lys Phe Leu Arg Arg Gln Asn His 
                885                 890                 895     


Pro Glu Ala Gly Glu Val Phe Val Arg Val Val Ala Ser Ser Asp Lys 
            900                 905                 910         


Xaa Val Glu Val Lys Pro Gly Met Lys Ser Arg Phe Val Asp Ser Gly 
        915                 920                 925             


Glu Met Ser Glu Ser Phe Pro Tyr Arg Xaa Lys Ala Leu Phe Ala Phe 
    930                 935                 940                 


Glu Glu Ile Asp Gly Val Asp Val Cys Phe Phe Gly Met His Val Gln 
945                 950                 955                 960 


Glu Tyr Gly Ser Asp Cys Pro Pro Pro Asn Xaa Arg Arg Val Tyr Ile 
                965                 970                 975     


Ser Tyr Leu Asp Ser Ile His Phe Phe Arg Pro Arg Cys Leu Arg Xaa 
            980                 985                 990         


Ala Val Tyr His Glu Ile Leu Ile  Gly Tyr Leu Glu Tyr  Val Lys Lys 
        995                 1000                 1005             


Leu Gly  Tyr Val Xaa Gly His  Ile Trp Ala Cys Pro  Pro Ser Glu 
    1010                 1015                 1020             


Gly Asp  Asp Tyr Ile Phe His  Cys His Pro Pro Asp  Gln Lys Ile 
    1025                 1030                 1035             


Pro Lys  Pro Lys Arg Leu Gln  Glu Trp Tyr Lys Lys  Met Leu Asp 
    1040                 1045                 1050             


Lys Ala  Phe Ala Glu Arg Ile  Ile His Asp Tyr Lys  Asp Ile Phe 
    1055                 1060                 1065             


Lys Gln  Ala Xaa Glu Asp Arg  Leu Xaa Ser Ala Lys  Glu Leu Pro 
    1070                 1075                 1080             


Tyr Phe  Glu Gly Asp Phe Trp  Pro Asn Val Leu Glu  Glu Ser Ile 
    1085                 1090                 1095             


Lys Glu  Leu Glu Gln Glu Glu  
    1100                 1105 


<210> 6893
<211> 254
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<400> 6893
Xaa Asp Gly Ser Asn Ser Gly Asn Ile Gly Xaa Leu Ser Xaa Ile Pro 
1               5                   10                  15      


Xaa Ala Ala Pro Pro Ser Ser Xaa Gly Val Arg Lys Gly Trp His Glu 
            20                  25                  30          


His Val Xaa Gln Asp Leu Arg Ser His Leu Val His Lys Leu Val Gln 
        35                  40                  45              


Ala Ile Phe Pro Xaa Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met 
    50                  55                  60                  


Glu Asn Leu Val Ala Tyr Ala Lys Lys Val Glu Gly Asp Met Tyr Glu 
65                  70                  75                  80  


Ser Ala Asn Ser Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile 
                85                  90                  95      


Tyr Lys Ile Gln Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg Leu His 
            100                 105                 110         


Lys Gln Gly Ile Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro Gly Ala 
        115                 120                 125             


Gln Pro Pro Val Ile Pro Gln Ala Gln Pro Val Arg Pro Pro Arg Met 
    130                 135                 140                 


Asn Ser Phe Asn Pro Met Ser Leu Gly Asn Val Gln Leu Pro Gln Ala 
145                 150                 155                 160 


Pro Met Gly Pro Arg Ala Ala Ser Pro Met Asn His Ser Val Gln Met 
                165                 170                 175     


Asn Ser Met Gly Ser Val Pro Gly Met Ala Ile Ser Pro Ser Arg Met 
            180                 185                 190         


Pro Gln Pro Pro Asn Met Met Gly Ala His Xaa Asn Asn Met Met Ala 
        195                 200                 205             


Gln Ala Pro Ala Gln Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro Ser 
    210                 215                 220                 


Ser Ser Gly Ala Met Ser Val Gly Met Gly Gln Pro Pro Ala Gln Xaa 
225                 230                 235                 240 


Gly Val Ser Gln Val Leu Cys Pro Xaa Gly Xaa Val Ala Pro 
                245                 250                 


<210> 6894
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<400> 6894
Xaa His Leu Leu Ala Glu Lys Ile Tyr Lys Ile Gln Lys Glu Leu Glu 
1               5                   10                  15      


Glu Lys Arg Arg Ser Arg Leu His Lys Gln Gly Ile Leu Gly Asn Gln 
            20                  25                  30          


Pro Ala Leu Pro Ala Pro Gly Ala Gln Pro Pro Val Ile Pro Gln Ala 
        35                  40                  45              


Gln Pro Val Arg Pro Pro Asn Gly Pro Leu Ser Leu Pro Val Asn Arg 
    50                  55                  60                  


Met Gln Val Ser Gln Gly Met Asn Ser Phe Asn Pro Met Ser Leu Gly 
65                  70                  75                  80  


Asn Val Gln Leu Pro Gln Ala Pro Met Gly Pro Arg Ala Ala Ser Pro 
                85                  90                  95      


Met Asn His Ser Val Gln Met Asn Ser Met Gly Ser Val Pro Gly Met 
            100                 105                 110         


Ala Ile Ser Pro Ser Arg Met Pro Gln Pro Pro Asn Met Met Gly Ala 
        115                 120                 125             


His Xaa Asn Asn Met Met Ala Gln Ala Pro Ala Gln Ser Gln Phe Leu 
    130                 135                 140                 


Pro Gln Asn Gln Phe Pro Ser Ser Ser Gly Ala Met Ser Val Gly Met 
145                 150                 155                 160 


Gly Gln Pro Pro Ala Gln Xaa Gly Val Ser Gln Val Leu Cys Pro Xaa 
                165                 170                 175     


Gly Xaa Val Ala Pro 
            180     


<210> 6895
<211> 196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<400> 6895
Xaa Arg Tyr His Phe Cys Glu Lys Cys Phe Xaa Glu Ile Gln Gly Glu 
1               5                   10                  15      


Asn Val Xaa Leu Gly Asp Asp Pro Ser Gln Pro Gln Xaa Xaa Ile Ser 
            20                  25                  30          


Lys Asp Gln Phe Glu Lys Lys Lys Asn Asp Xaa Leu Asp Pro Glu Pro 
        35                  40                  45              


Phe Val Asp Cys Lys Glu Cys Gly Arg Lys Met His Gln Ile Cys Val 
    50                  55                  60                  


Leu His Tyr Asp Ile Ile Trp Pro Ser Gly Phe Val Cys Asp Asn Cys 
65                  70                  75                  80  


Leu Lys Lys Xaa Gly Arg Pro Arg Lys Glu Asn Lys Phe Ser Ala Lys 
                85                  90                  95      


Arg Leu Gln Xaa Xaa Arg Leu Gly Asn His Leu Glu Asp Arg Val Asn 
            100                 105                 110         


Lys Phe Leu Arg Arg Gln Asn His Pro Glu Ala Gly Glu Val Phe Val 
        115                 120                 125             


Arg Val Val Ala Ser Ser Asp Lys Xaa Val Glu Val Lys Pro Gly Met 
    130                 135                 140                 


Lys Ser Arg Phe Val Asp Ser Gly Glu Met Ser Glu Ser Phe Pro Tyr 
145                 150                 155                 160 


Arg Xaa Lys Ala Leu Phe Ala Phe Glu Glu Ile Asp Gly Val Asp Val 
                165                 170                 175     


Cys Phe Phe Gly Met His Val Gln Glu Tyr Gly Ser Asp Cys Pro Pro 
            180                 185                 190         


Pro Asn Xaa Arg 
        195     


<210> 6896
<211> 33
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<400> 6896
Xaa Xaa Cys Asn Glu Cys Lys His His Val Glu Xaa Arg Trp His Cys 
1               5                   10                  15      


Xaa Val Cys Glu Phe Leu Asn Ala Ala Val Phe Ile Ser Phe Cys Glu 
            20                  25                  30          


His 
    


<210> 6897
<211> 120
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<400> 6897
Met Asp Asp Ser Lys Val Val Gly Gly Lys Val Lys Lys Pro Gly Lys 
1               5                   10                  15      


Arg Gly Arg Lys Pro Ala Lys Ile Asp Leu Lys Ala Lys Leu Glu Arg 
            20                  25                  30          


Ser Arg Gln Ser Ala Arg Glu Cys Arg Ala Arg Lys Lys Leu Arg Tyr 
        35                  40                  45              


Gln Tyr Leu Glu Glu Leu Val Ser Ser Arg Glu Arg Ala Ile Cys Ala 
    50                  55                  60                  


Leu Arg Glu Glu Leu Glu Met Tyr Lys Gln Trp Cys Met Ala Met Asp 
65                  70                  75                  80  


Gln Gly Lys Ile Pro Ser Glu Ile Lys Ala Leu Leu Xaa Gly Glu Glu 
                85                  90                  95      


Gln Asn Lys Ser Gln Gln Asn Ser Ser Arg His Xaa Lys Ala Gly Lys 
            100                 105                 110         


Xaa Asp Ala Asn Ser Asn Ser Trp 
        115                 120 


<210> 6898
<211> 26
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<400> 6898
Met Pro Gln Pro Ser Val Ser Gly Met Asp Pro Pro Phe Gly Asp Ala 
1               5                   10                  15      


Phe Arg Ser His Xaa Phe Ser Glu Gln Xaa 
            20                  25      


<210> 6899
<211> 417
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<400> 6899
Met Pro Gln Pro Ser Val Ser Gly Met Asp Pro Pro Phe Gly Asp Ala 
1               5                   10                  15      


Phe Arg Ser His Xaa Phe Ser Glu Gln Xaa Leu Met Ser Xaa Asp Leu 
            20                  25                  30          


Leu Ala Asn Ser Ser Asp Pro Asp Phe Met Tyr Glu Leu Asp Arg Glu 
        35                  40                  45              


Met Asn Tyr Gln Gln Asn Pro Arg Asp Asn Phe Leu Ser Leu Glu Asp 
    50                  55                  60                  


Cys Lys Asp Ile Glu Asn Leu Glu Ser Phe Xaa Asp Val Leu Asp Asn 
65                  70                  75                  80  


Glu Gly Ala Leu Xaa Ser Asn Trp Glu Gln Trp Asp Xaa Tyr Cys Glu 
                85                  90                  95      


Asp Leu Xaa Lys Tyr Xaa Lys Leu Xaa Ser Cys Asp Ile Trp Gly Xaa 
            100                 105                 110         


Lys Glu Val Asp Tyr Leu Gly Leu Asp Asp Phe Ser Ser Pro Tyr Gln 
        115                 120                 125             


Asp Glu Glu Val Ile Ser Lys Xaa Pro Xaa Leu Ala Gln Leu Asn Ser 
    130                 135                 140                 


Glu Asp Ser Gln Ser Val Ser Asp Ser Leu Tyr Tyr Pro Asp Ser Leu 
145                 150                 155                 160 


Phe Ser Val Lys Gln Asn Pro Leu Pro Ser Ser Phe Pro Gly Lys Lys 
                165                 170                 175     


Ile Xaa Ser Arg Ala Ala Ala Pro Val Cys Ser Ser Lys Xaa Leu Gln 
            180                 185                 190         


Ala Glu Val Pro Leu Ser Asp Cys Val Gln Lys Ala Ser Lys Pro Xaa 
        195                 200                 205             


Ser Ser Xaa Gln Ile Met Val Lys Xaa Asn Met Tyr His Asn Glu Lys 
    210                 215                 220                 


Val Asn Phe His Val Glu Cys Lys Asp Tyr Val Lys Lys Ala Lys Val 
225                 230                 235                 240 


Lys Ile Asn Pro Val Gln Gln Ser Arg Pro Leu Leu Ser Gln Ile His 
                245                 250                 255     


Xaa Asp Ala Ala Lys Glu Asn Xaa Cys Tyr Cys Gly Ala Val Ala Lys 
            260                 265                 270         


Arg Gln Glu Lys Lys Gly Met Glu Pro Leu Gln Gly His Ala Xaa Pro 
        275                 280                 285             


Ala Leu Pro Phe Lys Glu Xaa Gln Glu Leu Leu Leu Ser Pro Leu Pro 
    290                 295                 300                 


Gln Glu Gly Pro Gly Ser Leu Ala Ala Gly Glu Ser Ser Ser Leu Ser 
305                 310                 315                 320 


Ala Ser Xaa Ser Val Ser Asp Ser Ser Gln Lys Lys Glu Glu His Asn 
                325                 330                 335     


Tyr Ser Leu Phe Val Ser Asp Asn Leu Gly Glu Gln Pro Xaa Lys Cys 
            340                 345                 350         


Ser Pro Glu Glu Asp Glu Glu Asp Glu Glu Asp Val Asp Asp Glu Asp 
        355                 360                 365             


His Asp Glu Gly Phe Gly Ser Glu His Glu Leu Ser Glu Asn Glu Glu 
    370                 375                 380                 


Glu Glu Glu Glu Glu Glu Asp Tyr Glu Asp Asp Lys Asp Asp Asp Ile 
385                 390                 395                 400 


Ser Asp Xaa Phe Ser Glu Pro Gly Ile Ile Met Leu Ala Ser Leu Pro 
                405                 410                 415     


Asp 
    


<210> 6900
<211> 639
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<400> 6900
Met Pro Gln Pro Ser Val Ser Gly Met Asp Pro Pro Phe Gly Asp Ala 
1               5                   10                  15      


Phe Arg Ser His Xaa Phe Ser Glu Gln Xaa Leu Met Ser Xaa Asp Leu 
            20                  25                  30          


Leu Ala Asn Ser Ser Asp Pro Asp Phe Met Tyr Glu Leu Asp Arg Glu 
        35                  40                  45              


Met Asn Tyr Gln Gln Asn Pro Arg Asp Asn Phe Leu Ser Leu Glu Asp 
    50                  55                  60                  


Cys Lys Asp Ile Glu Asn Leu Glu Ser Phe Xaa Asp Val Leu Asp Asn 
65                  70                  75                  80  


Glu Gly Ala Leu Xaa Ser Asn Trp Glu Gln Trp Asp Xaa Tyr Cys Glu 
                85                  90                  95      


Asp Leu Xaa Lys Tyr Xaa Lys Leu Xaa Ser Cys Asp Ile Trp Gly Xaa 
            100                 105                 110         


Lys Glu Val Asp Tyr Leu Gly Leu Asp Asp Phe Ser Ser Pro Tyr Gln 
        115                 120                 125             


Asp Glu Glu Val Ile Ser Lys Xaa Pro Xaa Leu Ala Gln Leu Asn Ser 
    130                 135                 140                 


Glu Asp Ser Gln Ser Val Ser Asp Ser Leu Tyr Tyr Pro Asp Ser Leu 
145                 150                 155                 160 


Phe Ser Val Lys Gln Asn Pro Leu Pro Ser Ser Phe Pro Gly Lys Lys 
                165                 170                 175     


Ile Xaa Ser Arg Ala Ala Ala Pro Val Cys Ser Ser Lys Xaa Leu Gln 
            180                 185                 190         


Ala Glu Val Pro Leu Ser Asp Cys Val Gln Lys Ala Ser Lys Pro Xaa 
        195                 200                 205             


Ser Ser Xaa Gln Ile Met Val Lys Xaa Asn Met Tyr His Asn Glu Lys 
    210                 215                 220                 


Val Asn Phe His Val Glu Cys Lys Asp Tyr Val Lys Lys Ala Lys Val 
225                 230                 235                 240 


Lys Ile Asn Pro Val Gln Gln Ser Arg Pro Leu Leu Ser Gln Ile His 
                245                 250                 255     


Xaa Asp Ala Ala Lys Glu Asn Xaa Cys Tyr Cys Gly Ala Val Ala Lys 
            260                 265                 270         


Arg Gln Glu Lys Lys Gly Met Glu Pro Leu Gln Gly His Ala Xaa Pro 
        275                 280                 285             


Ala Leu Pro Phe Lys Glu Xaa Gln Glu Leu Leu Leu Ser Pro Leu Pro 
    290                 295                 300                 


Gln Glu Gly Pro Gly Ser Leu Ala Ala Gly Glu Ser Ser Ser Leu Ser 
305                 310                 315                 320 


Ala Ser Xaa Ser Val Ser Asp Ser Ser Gln Lys Lys Glu Glu His Asn 
                325                 330                 335     


Tyr Ser Leu Phe Val Ser Asp Asn Leu Gly Glu Gln Pro Xaa Lys Cys 
            340                 345                 350         


Ser Pro Glu Glu Asp Glu Glu Asp Glu Glu Asp Val Asp Asp Glu Asp 
        355                 360                 365             


His Asp Glu Gly Phe Gly Ser Glu His Glu Leu Ser Glu Asn Glu Glu 
    370                 375                 380                 


Glu Glu Glu Glu Glu Glu Asp Tyr Glu Asp Asp Lys Asp Asp Asp Ile 
385                 390                 395                 400 


Ser Asp Xaa Phe Ser Glu Pro Gly Tyr Glu Asn Asp Ser Val Glu Asp 
                405                 410                 415     


Leu Lys Glu Val Xaa Ser Ile Ser Ser Arg Lys Arg Gly Lys Arg Arg 
            420                 425                 430         


Tyr Phe Trp Glu Tyr Ser Glu Gln Leu Xaa Pro Ser Gln Gln Glu Arg 
        435                 440                 445             


Met Leu Arg Pro Ser Glu Trp Asn Arg Asp Xaa Leu Pro Ser Asn Met 
    450                 455                 460                 


Tyr Gln Lys Asn Gly Leu His His Gly Lys Tyr Ala Val Lys Lys Ser 
465                 470                 475                 480 


Arg Arg Xaa Asp Val Glu Asp Leu Xaa Pro Asn Pro Lys Lys Leu Leu 
                485                 490                 495     


Gln Ile Gly Asn Glu Leu Arg Lys Leu Asn Lys Val Ile Ser Asp Leu 
            500                 505                 510         


Xaa Pro Val Ser Glu Leu Pro Leu Xaa Ala Arg Pro Arg Ser Arg Lys 
        515                 520                 525             


Glu Lys Asn Lys Leu Ala Ser Arg Ala Cys Arg Leu Lys Lys Lys Ala 
    530                 535                 540                 


Gln Tyr Glu Ala Asn Lys Val Lys Leu Trp Gly Leu Asn Xaa Glu Tyr 
545                 550                 555                 560 


Asp Asn Leu Leu Phe Val Ile Asn Ser Ile Lys Gln Glu Ile Val Asn 
                565                 570                 575     


Arg Val Gln Asn Pro Arg Asp Glu Arg Gly Pro Asn Met Gly Gln Lys 
            580                 585                 590         


Leu Glu Ile Leu Ile Lys Asp Xaa Leu Gly Leu Pro Val Ala Gly Gln 
        595                 600                 605             


Xaa Ser Glu Phe Val Asn Gln Val Leu Glu Lys Xaa Ala Glu Gly Asn 
    610                 615                 620                 


Pro Xaa Gly Gly Leu Val Gly Leu Arg Ile Pro Xaa Ser Lys Val 
625                 630                 635                 


<210> 6901
<211> 67
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 6901
Met Arg Ala Asp Pro Pro Ala Ser Leu Pro Leu Leu Leu Pro Pro Xaa 
1               5                   10                  15      


Xaa Phe Ser Phe Leu Gly Asp Phe Leu Pro Ala Arg Leu Arg Cys Arg 
            20                  25                  30          


Gly Tyr Arg Xaa Val Val Pro Ala Ser Gln Pro Val Asp Xaa Ala Val 
        35                  40                  45              


Gly Ala Glu Glu Xaa Gly Pro Ala Ala Gly His Ile Ser Cys Phe Ile 
    50                  55                  60                  


Leu Lys Ala 
65          


<210> 6902
<211> 354
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(293)
<223> Selenocysteine

<400> 6902
Met Arg His Ser Leu Xaa Lys Leu Leu Ala Ala Ser Gly Ser Asn Ser 
1               5                   10                  15      


Pro Xaa Arg Ser Glu Ser Pro Glu Pro Ala Ala Xaa Cys Ser Leu Pro 
            20                  25                  30          


Ser Asp Leu Xaa Arg Ala Ala Ala Gly Glu Glu Glu Xaa Ala Ala Ala 
        35                  40                  45              


Gly Ser Pro Gly Arg Lys Gln Gln Phe Gly Asp Glu Gly Glu Leu Glu 
    50                  55                  60                  


Ala Gly Arg Gly Ser Arg Gly Gly Val Ala Val Arg Ala Pro Ser Pro 
65                  70                  75                  80  


Glu Glu Met Glu Glu Glu Ala Ile Ala Ser Leu Pro Gly Glu Glu Xaa 
                85                  90                  95      


Glu Asp Met Asp Phe Leu Ser Gly Leu Glu Leu Ala Asp Leu Leu Asp 
            100                 105                 110         


Pro Arg Gln Pro Asp Trp His Leu Asp Pro Gly Leu Ser Ser Pro Gly 
        115                 120                 125             


Pro Leu Ser Ser Ser Gly Gly Gly Ser Asp Ser Gly Gly Leu Trp Arg 
    130                 135                 140                 


Gly Asp Asp Asp Asp Glu Ala Ala Ala Ala Glu Met Gln Arg Phe Ser 
145                 150                 155                 160 


Asp Leu Leu Gln Arg Leu Leu Asn Gly Ile Gly Gly Cys Ser Ser Ser 
                165                 170                 175     


Ser Asp Ser Gly Ser Ala Glu Lys Arg Arg Arg Lys Ser Pro Gly Gly 
            180                 185                 190         


Gly Gly Gly Gly Gly Ser Gly Asn Asp Asn Asn Gln Ala Ala Xaa Lys 
        195                 200                 205             


Ser Pro Arg Lys Ala Ala Ala Ala Ala Ala Arg Leu Asn Arg Leu Lys 
    210                 215                 220                 


Lys Lys Glu Tyr Val Met Gly Leu Glu Ser Arg Val Arg Gly Leu Ala 
225                 230                 235                 240 


Ala Glu Asn Gln Glu Leu Arg Ala Glu Asn Arg Glu Leu Gly Lys Arg 
                245                 250                 255     


Val Gln Ala Leu Gln Glu Glu Ser Arg Tyr Leu Arg Ala Val Leu Ala 
            260                 265                 270         


Asn Glu Xaa Gly Leu Ala Arg Leu Leu Ser Arg Leu Ser Gly Val Gly 
        275                 280                 285             


Leu Arg Leu Xaa Xaa Ser Leu Phe Arg Asp Ser Pro Ala Gly Asp His 
    290                 295                 300                 


Asp Tyr Ala Leu Pro Val Gly Lys Gln Lys Gln Asp Leu Leu Glu Glu 
305                 310                 315                 320 


Asp Asp Ser Ala Gly Gly Val Cys Leu His Val Asp Lys Asp Lys Val 
                325                 330                 335     


Ser Val Glu Phe Cys Ser Ala Cys Ala Arg Lys Ala Ser Ser Ser Leu 
            340                 345                 350         


Lys Met 
        


<210> 6903
<211> 358
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(293)
<223> Selenocysteine

<400> 6903
Met Arg His Ser Leu Xaa Lys Leu Leu Ala Ala Ser Gly Ser Asn Ser 
1               5                   10                  15      


Pro Xaa Arg Ser Glu Ser Pro Glu Pro Ala Ala Xaa Cys Ser Leu Pro 
            20                  25                  30          


Ser Asp Leu Xaa Arg Ala Ala Ala Gly Glu Glu Glu Xaa Ala Ala Ala 
        35                  40                  45              


Gly Ser Pro Gly Arg Lys Gln Gln Phe Gly Asp Glu Gly Glu Leu Glu 
    50                  55                  60                  


Ala Gly Arg Gly Ser Arg Gly Gly Val Ala Val Arg Ala Pro Ser Pro 
65                  70                  75                  80  


Glu Glu Met Glu Glu Glu Ala Ile Ala Ser Leu Pro Gly Glu Glu Xaa 
                85                  90                  95      


Glu Asp Met Asp Phe Leu Ser Gly Leu Glu Leu Ala Asp Leu Leu Asp 
            100                 105                 110         


Pro Arg Gln Pro Asp Trp His Leu Asp Pro Gly Leu Ser Ser Pro Gly 
        115                 120                 125             


Pro Leu Ser Ser Ser Gly Gly Gly Ser Asp Ser Gly Gly Leu Trp Arg 
    130                 135                 140                 


Gly Asp Asp Asp Asp Glu Ala Ala Ala Ala Glu Met Gln Arg Phe Ser 
145                 150                 155                 160 


Asp Leu Leu Gln Arg Leu Leu Asn Gly Ile Gly Gly Cys Ser Ser Ser 
                165                 170                 175     


Ser Asp Ser Gly Ser Ala Glu Lys Arg Arg Arg Lys Ser Pro Gly Gly 
            180                 185                 190         


Gly Gly Gly Gly Gly Ser Gly Asn Asp Asn Asn Gln Ala Ala Xaa Lys 
        195                 200                 205             


Ser Pro Arg Lys Ala Ala Ala Ala Ala Ala Arg Leu Asn Arg Leu Lys 
    210                 215                 220                 


Lys Lys Glu Tyr Val Met Gly Leu Glu Ser Arg Val Arg Gly Leu Ala 
225                 230                 235                 240 


Ala Glu Asn Gln Glu Leu Arg Ala Glu Asn Arg Glu Leu Gly Lys Arg 
                245                 250                 255     


Val Gln Ala Leu Gln Glu Glu Ser Arg Tyr Leu Arg Ala Val Leu Ala 
            260                 265                 270         


Asn Glu Xaa Gly Leu Ala Arg Leu Leu Ser Arg Leu Ser Gly Val Gly 
        275                 280                 285             


Leu Arg Leu Xaa Xaa Ser Leu Phe Arg Asp Ser Pro Ala Gly Asp His 
    290                 295                 300                 


Asp Tyr Ala Leu Pro Val Gly Lys Gln Lys Gln Asp Leu Leu Glu Glu 
305                 310                 315                 320 


Asp Asp Ser Ala Gly Gly Val Cys Leu His Val Asp Lys Asp Lys Val 
                325                 330                 335     


Ser Val Glu Phe Cys Ser Ala Cys Ala Arg Lys Ala Ser Ser Ser Leu 
            340                 345                 350         


Lys Ile Phe Phe Phe Arg 
        355             


<210> 6904
<211> 284
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(219)
<223> Selenocysteine

<400> 6904
Val Arg Ala Pro Ser Pro Glu Glu Met Glu Glu Glu Ala Ile Ala Ser 
1               5                   10                  15      


Leu Pro Gly Glu Glu Xaa Glu Asp Met Asp Phe Leu Ser Gly Leu Glu 
            20                  25                  30          


Leu Ala Asp Leu Leu Asp Pro Arg Gln Pro Asp Trp His Leu Asp Pro 
        35                  40                  45              


Gly Leu Ser Ser Pro Gly Pro Leu Ser Ser Ser Gly Gly Gly Ser Asp 
    50                  55                  60                  


Ser Gly Gly Leu Trp Arg Gly Asp Asp Asp Asp Glu Ala Ala Ala Ala 
65                  70                  75                  80  


Glu Met Gln Arg Phe Ser Asp Leu Leu Gln Arg Leu Leu Asn Gly Ile 
                85                  90                  95      


Gly Gly Cys Ser Ser Ser Ser Asp Ser Gly Ser Ala Glu Lys Arg Arg 
            100                 105                 110         


Arg Lys Ser Pro Gly Gly Gly Gly Gly Gly Gly Ser Gly Asn Asp Asn 
        115                 120                 125             


Asn Gln Ala Ala Xaa Lys Ser Pro Arg Lys Ala Ala Ala Ala Ala Ala 
    130                 135                 140                 


Arg Leu Asn Arg Leu Lys Lys Lys Glu Tyr Val Met Gly Leu Glu Ser 
145                 150                 155                 160 


Arg Val Arg Gly Leu Ala Ala Glu Asn Gln Glu Leu Arg Ala Glu Asn 
                165                 170                 175     


Arg Glu Leu Gly Lys Arg Val Gln Ala Leu Gln Glu Glu Ser Arg Tyr 
            180                 185                 190         


Leu Arg Ala Val Leu Ala Asn Glu Xaa Gly Leu Ala Arg Leu Leu Ser 
        195                 200                 205             


Arg Leu Ser Gly Val Gly Leu Arg Leu Xaa Xaa Ser Leu Phe Arg Asp 
    210                 215                 220                 


Ser Pro Ala Gly Asp His Asp Tyr Ala Leu Pro Val Gly Lys Gln Lys 
225                 230                 235                 240 


Gln Asp Leu Leu Glu Glu Asp Asp Ser Ala Gly Gly Val Cys Leu His 
                245                 250                 255     


Val Asp Lys Asp Lys Val Ser Val Glu Phe Cys Ser Ala Cys Ala Arg 
            260                 265                 270         


Lys Ala Ser Ser Ser Leu Lys Ile Phe Phe Phe Arg 
        275                 280                 


<210> 6905
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(65)
<223> Selenocysteine

<400> 6905
Xaa Met Gly Leu Glu Ser Arg Val Arg Gly Leu Ala Ala Glu Asn Gln 
1               5                   10                  15      


Glu Leu Arg Ala Glu Asn Arg Glu Leu Gly Lys Arg Val Gln Ala Leu 
            20                  25                  30          


Gln Glu Glu Ser Arg Tyr Leu Arg Ala Val Leu Ala Asn Glu Xaa Gly 
        35                  40                  45              


Leu Ala Arg Leu Leu Ser Arg Leu Ser Gly Val Gly Leu Arg Leu Xaa 
    50                  55                  60                  


Xaa Ser Leu Phe Arg Asp Ser Pro Ala Gly Asp His Asp Tyr Ala Leu 
65                  70                  75                  80  


Pro Val Gly Lys Gln Lys Gln Asp Leu Leu Glu Glu Asp Asp Ser Ala 
                85                  90                  95      


Gly Gly Val Cys Leu His Val Asp Lys Asp Lys Val Ser Val Glu Phe 
            100                 105                 110         


Cys Ser Ala Cys Ala Arg Lys Ala Ser Ser Ser Leu Lys Ile Phe Phe 
        115                 120                 125             


Phe Arg 
    130 


<210> 6906
<211> 102
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<400> 6906
Met Ala Ala Ala Xaa Gly Asp Met Pro Xaa Tyr Gln Ile Arg Ala Pro 
1               5                   10                  15      


Xaa Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro Gly Ser 
            20                  25                  30          


Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Xaa Arg Lys Arg Glu 
        35                  40                  45              


Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Arg Glu Cys Arg Arg Lys 
    50                  55                  60                  


Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn Arg Val Ala Val Leu Glu 
65                  70                  75                  80  


Asn Gln Asn Lys Xaa Leu Ile Glu Glu Leu Lys Ala Leu Lys Asp Leu 
                85                  90                  95      


Tyr Cys His Lys Val Glu 
            100         


<210> 6907
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<400> 6907
Met Ala Val Pro Xaa Ser Ile Tyr Gln Xaa Ser Xaa Gly Gln Tyr Ile 
1               5                   10                  15      


Ala Ile Ala Gln Gly Gly Xaa Ile Gln Ile Ser Asn Pro Gly Ser Asp 
            20                  25                  30          


Gly Val Gln Gly Leu Gln Ala Leu Xaa Met Xaa Asn Ser Gly Ala Pro 
        35                  40                  45              


Pro Pro Gly Ala Xaa Ile Val Gln Tyr Ala Ala Gln Ser Ala Asp Gly 
    50                  55                  60                  


Xaa Gln Gln Phe Phe Val Pro Gly Ser Gln Val Val Val Gln 
65                  70                  75              


<210> 6908
<211> 116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<400> 6908
Met Ala Val Pro Xaa Ser Ile Tyr Gln Xaa Ser Xaa Gly Gln Tyr Ile 
1               5                   10                  15      


Ala Ile Ala Gln Gly Gly Xaa Ile Gln Ile Ser Asn Pro Gly Ser Asp 
            20                  25                  30          


Gly Val Gln Gly Leu Gln Ala Leu Xaa Met Xaa Asn Ser Gly Ala Pro 
        35                  40                  45              


Pro Pro Gly Ala Xaa Ile Val Gln Tyr Ala Ala Gln Ser Ala Asp Gly 
    50                  55                  60                  


Xaa Gln Gln Phe Phe Val Pro Gly Ser Gln Val Val Val Gln Ala Ala 
65                  70                  75                  80  


Xaa Gly Asp Met Pro Xaa Tyr Gln Ile Arg Ala Pro Xaa Ala Ala Leu 
                85                  90                  95      


Pro Gln Gly Val Val Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro 
            100                 105                 110         


Gln Gln Leu Ala 
        115     


<210> 6909
<211> 109
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<400> 6909
Met Ala Val Xaa Gly Asp Asp Xaa Ala Ala Xaa Gly Asp Met Pro Xaa 
1               5                   10                  15      


Tyr Gln Ile Arg Ala Pro Xaa Ala Ala Leu Pro Gln Gly Val Val Met 
            20                  25                  30          


Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu 
        35                  40                  45              


Ala Xaa Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala 
    50                  55                  60                  


Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser 
65                  70                  75                  80  


Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu 
                85                  90                  95      


Glu Xaa Leu Lys Asp Ile Cys Ser Pro Lys Xaa Asp Tyr 
            100                 105                 


<210> 6910
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<400> 6910
Met Ala Val Xaa Gly Asp Asp Xaa Ala Ala Xaa Gly Asp Met Pro Xaa 
1               5                   10                  15      


Tyr Gln Ile Arg Ala Pro Xaa Ala Ala Leu Pro Gln Gly Val Val Met 
            20                  25                  30          


Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu 
        35                  40                  45              


Ala Xaa Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala 
    50                  55                  60                  


Arg Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn 
65                  70                  75                  80  


Arg Val Ala Val Leu Glu Asn Gln Asn Lys Xaa Leu Ile Glu Glu Leu 
                85                  90                  95      


Lys Ala Leu Lys Asp Leu Tyr Cys His Lys Val Glu 
            100                 105             


<210> 6911
<211> 121
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<400> 6911
Met Ala Val Xaa Gly Asp Asp Xaa Asp Glu Glu Xaa Glu Leu Ala Pro 
1               5                   10                  15      


Ser His Met Ala Ala Ala Xaa Gly Asp Met Pro Xaa Tyr Gln Ile Arg 
            20                  25                  30          


Ala Pro Xaa Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro 
        35                  40                  45              


Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Xaa Arg Lys 
    50                  55                  60                  


Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys Arg 
65                  70                  75                  80  


Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala Val 
                85                  90                  95      


Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Xaa Leu Lys 
            100                 105                 110         


Asp Ile Cys Ser Pro Lys Xaa Asp Tyr 
        115                 120     


<210> 6912
<211> 120
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 6912
Met Ala Val Xaa Gly Asp Asp Xaa Asp Glu Glu Xaa Glu Leu Ala Pro 
1               5                   10                  15      


Ser His Met Ala Ala Ala Xaa Gly Asp Met Pro Xaa Tyr Gln Ile Arg 
            20                  25                  30          


Ala Pro Xaa Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro 
        35                  40                  45              


Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Xaa Arg Lys 
    50                  55                  60                  


Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Arg Glu Cys Arg 
65                  70                  75                  80  


Arg Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn Arg Val Ala Val 
                85                  90                  95      


Leu Glu Asn Gln Asn Lys Xaa Leu Ile Glu Glu Leu Lys Ala Leu Lys 
            100                 105                 110         


Asp Leu Tyr Cys His Lys Val Glu 
        115                 120 


<210> 6913
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 6913
Met Asn Arg Xaa Gln Glu Leu Ser Gly Gln Leu Ser Ala Ala Xaa Gly 
1               5                   10                  15      


Asp Met Pro Xaa Tyr Gln Ile Arg Ala Pro Xaa Ala Ala Leu Pro Gln 
            20                  25                  30          


Gly Val Val Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln 
        35                  40                  45              


Leu Ala Glu Glu Ala Xaa Arg Lys Arg Glu Leu Arg Leu Met Lys Asn 
    50                  55                  60                  


Arg Glu Ala Ala Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys 
65                  70                  75                  80  


Cys Leu Glu Ser Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu 
                85                  90                  95      


Ile Glu Glu Leu Glu Xaa Leu Lys Asp Ile Cys Ser Pro Lys Xaa Asp 
            100                 105                 110         


Tyr 
    


<210> 6914
<211> 112
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 6914
Met Asn Arg Xaa Gln Glu Leu Ser Gly Gln Leu Ser Ala Ala Xaa Gly 
1               5                   10                  15      


Asp Met Pro Xaa Tyr Gln Ile Arg Ala Pro Xaa Ala Ala Leu Pro Gln 
            20                  25                  30          


Gly Val Val Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln 
        35                  40                  45              


Leu Ala Glu Glu Ala Xaa Arg Lys Arg Glu Leu Arg Leu Met Lys Asn 
    50                  55                  60                  


Arg Glu Ala Ala Arg Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys 
65                  70                  75                  80  


Cys Leu Glu Asn Arg Val Ala Val Leu Glu Asn Gln Asn Lys Xaa Leu 
                85                  90                  95      


Ile Glu Glu Leu Lys Ala Leu Lys Asp Leu Tyr Cys His Lys Val Glu 
            100                 105                 110         


<210> 6915
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<400> 6915
Met Asn Arg Xaa Gln Glu Leu Ser Gly Gln Leu Ser Asp Glu Glu Xaa 
1               5                   10                  15      


Glu Leu Ala Pro Ser His Met Ala Ala Ala Xaa Gly Asp Met Pro Xaa 
            20                  25                  30          


Tyr Gln Ile Arg Ala Pro Xaa Ala Ala Leu Pro Gln Gly Val Val Met 
        35                  40                  45              


Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu 
    50                  55                  60                  


Ala Xaa Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala 
65                  70                  75                  80  


Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser 
                85                  90                  95      


Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu 
            100                 105                 110         


Glu Xaa Leu Lys Asp Ile Cys Ser Pro Lys Xaa Asp Tyr 
        115                 120                 125 


<210> 6916
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<400> 6916
Met Pro Xaa Tyr Gln Ile Arg Ala Pro Xaa Ala Ala Leu Pro Gln Gly 
1               5                   10                  15      


Val Val Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu 
            20                  25                  30          


Ala Glu Glu Ala Xaa Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg 
        35                  40                  45              


Glu Ala Ala Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys 
    50                  55                  60                  


Leu Glu Ser Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile 
65                  70                  75                  80  


Glu Glu Leu Glu Xaa Leu Lys Asp Ile Cys Ser Pro Lys Xaa Asp Tyr 
                85                  90                  95      


<210> 6917
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 6917
Met Pro Xaa Tyr Gln Ile Arg Ala Pro Xaa Ala Ala Leu Pro Gln Gly 
1               5                   10                  15      


Val Val Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu 
            20                  25                  30          


Ala Glu Glu Ala Xaa Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg 
        35                  40                  45              


Glu Ala Ala Arg Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys Cys 
    50                  55                  60                  


Leu Glu Asn Arg Val Ala Val Leu Glu Asn Gln Asn Lys Xaa Leu Ile 
65                  70                  75                  80  


Glu Glu Leu Lys Ala Leu Lys Asp Leu Tyr Cys His Lys Val Glu 
                85                  90                  95  


<210> 6918
<211> 157
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<400> 6918
Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Xaa Asn Pro Arg Gln 
1               5                   10                  15      


Met Xaa Met Glu Xaa Val Glu Ser Gln His Asp Gly Ser Ile Xaa Ala 
            20                  25                  30          


Ser Leu Xaa Glu Ser Lys Ser Ala His Val Gln Xaa Gln Xaa Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Xaa Asp 
    50                  55                  60                  


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
65                  70                  75                  80  


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
                85                  90                  95      


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
            100                 105                 110         


Glu Gly Xaa Pro Pro Ser Ile Ala Xaa Met Ala Val Pro Xaa Ser Ile 
        115                 120                 125             


Tyr Gln Xaa Ser Xaa Gly Gln Tyr Ile Ala Ile Ala Gln Gly Gly Xaa 
    130                 135                 140                 


Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly 
145                 150                 155         


<210> 6919
<211> 299
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<400> 6919
Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Xaa Asn Pro Arg Gln 
1               5                   10                  15      


Met Xaa Met Glu Xaa Val Glu Ser Gln His Asp Gly Ser Ile Xaa Ala 
            20                  25                  30          


Ser Leu Xaa Glu Ser Lys Ser Ala His Val Gln Xaa Gln Xaa Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Xaa Asp 
    50                  55                  60                  


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
65                  70                  75                  80  


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
                85                  90                  95      


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
            100                 105                 110         


Glu Gly Xaa Pro Pro Ser Ile Ala Xaa Met Ala Val Pro Xaa Ser Ile 
        115                 120                 125             


Tyr Gln Xaa Ser Xaa Gly Gln Tyr Ile Ala Ile Ala Gln Gly Gly Xaa 
    130                 135                 140                 


Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly Leu Gln Ala 
145                 150                 155                 160 


Leu Xaa Met Xaa Asn Ser Gly Ala Pro Pro Pro Gly Ala Xaa Ile Val 
                165                 170                 175     


Gln Tyr Ala Ala Gln Ser Ala Asp Gly Xaa Gln Gln Phe Phe Val Pro 
            180                 185                 190         


Gly Ser Gln Val Val Val Gln Ala Ala Xaa Gly Asp Met Pro Xaa Tyr 
        195                 200                 205             


Gln Ile Arg Ala Pro Xaa Ala Ala Leu Pro Gln Gly Val Val Met Ala 
    210                 215                 220                 


Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala 
225                 230                 235                 240 


Xaa Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Arg 
                245                 250                 255     


Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn Arg 
            260                 265                 270         


Val Ala Val Leu Glu Asn Gln Asn Lys Xaa Leu Ile Glu Glu Leu Lys 
        275                 280                 285             


Ala Leu Lys Asp Leu Tyr Cys His Lys Val Glu 
    290                 295                 


<210> 6920
<211> 300
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<400> 6920
Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Xaa Asn Pro Arg Gln 
1               5                   10                  15      


Met Xaa Met Glu Xaa Val Glu Ser Gln His Asp Gly Ser Ile Xaa Ala 
            20                  25                  30          


Ser Leu Xaa Glu Ser Lys Ser Ala His Val Gln Xaa Gln Xaa Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Xaa Asp 
    50                  55                  60                  


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
65                  70                  75                  80  


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
                85                  90                  95      


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
            100                 105                 110         


Glu Gly Xaa Pro Pro Ser Ile Ala Xaa Met Ala Val Pro Xaa Ser Ile 
        115                 120                 125             


Tyr Gln Xaa Ser Xaa Gly Gln Tyr Ile Ala Ile Ala Gln Gly Gly Xaa 
    130                 135                 140                 


Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly Leu Gln Ala 
145                 150                 155                 160 


Leu Xaa Met Xaa Asn Ser Gly Ala Pro Pro Pro Gly Ala Xaa Ile Val 
                165                 170                 175     


Gln Tyr Ala Ala Gln Ser Ala Asp Gly Xaa Gln Gln Phe Phe Val Pro 
            180                 185                 190         


Gly Ser Gln Val Val Val Gln Ala Ala Xaa Gly Asp Met Pro Xaa Tyr 
        195                 200                 205             


Gln Ile Arg Ala Pro Xaa Ala Ala Leu Pro Gln Gly Val Val Met Ala 
    210                 215                 220                 


Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala 
225                 230                 235                 240 


Xaa Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys 
                245                 250                 255     


Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg 
            260                 265                 270         


Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu 
        275                 280                 285             


Xaa Leu Lys Asp Ile Cys Ser Pro Lys Xaa Asp Tyr 
    290                 295                 300 


<210> 6921
<211> 312
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<400> 6921
Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Xaa Asn Pro Arg Gln 
1               5                   10                  15      


Met Xaa Met Glu Xaa Val Glu Ser Gln His Asp Gly Ser Ile Xaa Ala 
            20                  25                  30          


Ser Leu Xaa Glu Ser Lys Ser Ala His Val Gln Xaa Gln Xaa Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Xaa Asp 
    50                  55                  60                  


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
65                  70                  75                  80  


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
                85                  90                  95      


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
            100                 105                 110         


Glu Gly Xaa Pro Pro Ser Ile Ala Xaa Met Ala Val Pro Xaa Ser Ile 
        115                 120                 125             


Tyr Gln Xaa Ser Xaa Gly Gln Tyr Ile Ala Ile Ala Gln Gly Gly Xaa 
    130                 135                 140                 


Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly Leu Gln Ala 
145                 150                 155                 160 


Leu Xaa Met Xaa Asn Ser Gly Ala Pro Pro Pro Gly Ala Xaa Ile Val 
                165                 170                 175     


Gln Tyr Ala Ala Gln Ser Ala Asp Gly Xaa Gln Gln Phe Phe Val Pro 
            180                 185                 190         


Gly Ser Gln Val Val Val Gln Asp Glu Glu Xaa Glu Leu Ala Pro Ser 
        195                 200                 205             


His Met Ala Ala Ala Xaa Gly Asp Met Pro Xaa Tyr Gln Ile Arg Ala 
    210                 215                 220                 


Pro Xaa Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro Gly 
225                 230                 235                 240 


Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Xaa Arg Lys Arg 
                245                 250                 255     


Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys Arg Arg 
            260                 265                 270         


Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala Val Leu 
        275                 280                 285             


Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Xaa Leu Lys Asp 
    290                 295                 300                 


Ile Cys Ser Pro Lys Xaa Asp Tyr 
305                 310         


<210> 6922
<211> 248
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<400> 6922
Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Xaa Asn Pro Arg Gln 
1               5                   10                  15      


Met Xaa Met Glu Xaa Val Glu Ser Gln His Asp Gly Ser Ile Xaa Ala 
            20                  25                  30          


Ser Leu Xaa Glu Ser Lys Ser Ala His Val Gln Xaa Gln Xaa Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Xaa Asp 
    50                  55                  60                  


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
65                  70                  75                  80  


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
                85                  90                  95      


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
            100                 105                 110         


Glu Gly Xaa Pro Pro Ser Ile Ala Xaa Met Ala Val Pro Xaa Ser Ile 
        115                 120                 125             


Tyr Gln Xaa Ser Xaa Gly Gln Tyr Asn Glu Glu Xaa Glu Leu Ala Pro 
    130                 135                 140                 


Ser His Met Ala Ala Ala Xaa Gly Asp Met Pro Xaa Tyr Gln Ile Arg 
145                 150                 155                 160 


Ala Pro Xaa Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro 
                165                 170                 175     


Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Xaa Arg Lys 
            180                 185                 190         


Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Arg Glu Cys Arg 
        195                 200                 205             


Arg Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn Arg Val Ala Val 
    210                 215                 220                 


Leu Glu Asn Gln Asn Lys Xaa Leu Ile Glu Glu Leu Lys Ala Leu Lys 
225                 230                 235                 240 


Asp Leu Tyr Cys His Lys Val Glu 
                245             


<210> 6923
<211> 236
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<400> 6923
Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Xaa Asn Pro Arg Gln 
1               5                   10                  15      


Met Xaa Met Glu Xaa Val Glu Ser Gln His Asp Gly Ser Ile Xaa Ala 
            20                  25                  30          


Ser Leu Xaa Glu Ser Lys Ser Ala His Val Gln Xaa Gln Xaa Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Xaa Asp 
    50                  55                  60                  


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
65                  70                  75                  80  


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
                85                  90                  95      


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
            100                 105                 110         


Glu Gly Xaa Pro Pro Ser Ile Ala Xaa Met Ala Val Pro Xaa Ser Ile 
        115                 120                 125             


Tyr Gln Xaa Ser Xaa Gly Gln Tyr Xaa Ala Xaa Gly Asp Met Pro Xaa 
    130                 135                 140                 


Tyr Gln Ile Arg Ala Pro Xaa Ala Ala Leu Pro Gln Gly Val Val Met 
145                 150                 155                 160 


Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu 
                165                 170                 175     


Ala Xaa Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala 
            180                 185                 190         


Arg Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn 
        195                 200                 205             


Arg Val Ala Val Leu Glu Asn Gln Asn Lys Xaa Leu Ile Glu Glu Leu 
    210                 215                 220                 


Lys Ala Leu Lys Asp Leu Tyr Cys His Lys Val Glu 
225                 230                 235     


<210> 6924
<211> 59
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<400> 6924
Met Xaa Met Glu Xaa Val Glu Ser Gln His Asp Gly Ser Ile Xaa Ala 
1               5                   10                  15      


Ser Leu Xaa Glu Ser Lys Ser Ala His Val Gln Xaa Gln Xaa Gly Gln 
            20                  25                  30          


Asn Ser Ile Pro Ala Leu Ala Gln Cys Xaa Met Cys Lys Glu Ser Leu 
        35                  40                  45              


Gly Ile Lys Gln Pro Trp His Ala Ile Gly Asp 
    50                  55                  


<210> 6925
<211> 46
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<400> 6925
Met Xaa Met Glu Xaa Val Glu Ser Gln His Asp Gly Ser Ile Xaa Ala 
1               5                   10                  15      


Ser Leu Xaa Glu Ser Lys Ser Ala His Val Gln Xaa Gln Xaa Gly Gln 
            20                  25                  30          


Asn Ser Ile Pro Ala Leu Ala Gln Lys Ile Leu Tyr Tyr Arg 
        35                  40                  45      


<210> 6926
<211> 62
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<400> 6926
Met Xaa Met Glu Xaa Val Glu Ser Gln His Asp Gly Ser Ile Xaa Ala 
1               5                   10                  15      


Ser Leu Xaa Glu Ser Lys Ser Ala His Val Gln Xaa Gln Xaa Gly Gln 
            20                  25                  30          


Asn Ser Ile Pro Ala Leu Ala Gln Leu Pro Leu Val Xaa Cys Gln Leu 
        35                  40                  45              


Xaa Arg Ser Glu Leu Leu Leu Leu Leu Cys His Arg Glu Trp 
    50                  55                  60          


<210> 6927
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 6927
Met Xaa Met Glu Xaa Val Glu Ser Gln His Asp Gly Ser Ile Xaa Ala 
1               5                   10                  15      


Ser Leu Xaa Glu Ser Lys Ser Ala His Val Gln Xaa Gln Xaa Gly Gln 
            20                  25                  30          


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Xaa Asp 
        35                  40                  45              


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
    50                  55                  60                  


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
65                  70                  75                  80  


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
                85                  90                  95      


Glu Gly Xaa Pro Pro Ser Ile Ala Xaa Met Ala Val Pro Xaa Ser Ile 
            100                 105                 110         


Tyr Gln Xaa Ser Xaa Gly Gln Tyr Ser Met Tyr Ala Ala Ile Arg Tyr 
        115                 120                 125             


Asp Xaa Val Leu Ala Leu Ser Leu Leu 
    130                 135         


<210> 6928
<211> 187
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 6928
Met Xaa Met Glu Xaa Val Glu Ser Gln His Asp Gly Ser Ile Xaa Ala 
1               5                   10                  15      


Ser Leu Xaa Glu Ser Lys Ser Ala His Val Gln Xaa Gln Xaa Gly Gln 
            20                  25                  30          


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Xaa Asp 
        35                  40                  45              


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
    50                  55                  60                  


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
65                  70                  75                  80  


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
                85                  90                  95      


Glu Gly Xaa Pro Pro Ser Ile Ala Xaa Met Ala Val Pro Xaa Ser Ile 
            100                 105                 110         


Tyr Gln Xaa Ser Xaa Gly Gln Tyr Xaa Ala Xaa Gly Asp Met Pro Xaa 
        115                 120                 125             


Tyr Gln Ile Arg Ala Pro Xaa Ala Ala Leu Pro Gln Gly Val Val Met 
    130                 135                 140                 


Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu 
145                 150                 155                 160 


Ala Xaa Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala 
                165                 170                 175     


Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val 
            180                 185         


<210> 6929
<211> 221
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<400> 6929
Met Xaa Met Glu Xaa Val Glu Ser Gln His Asp Gly Ser Ile Xaa Ala 
1               5                   10                  15      


Ser Leu Xaa Glu Ser Lys Ser Ala His Val Gln Xaa Gln Xaa Gly Gln 
            20                  25                  30          


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Xaa Asp 
        35                  40                  45              


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
    50                  55                  60                  


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
65                  70                  75                  80  


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
                85                  90                  95      


Glu Gly Xaa Pro Pro Ser Ile Ala Xaa Met Ala Val Pro Xaa Ser Ile 
            100                 105                 110         


Tyr Gln Xaa Ser Xaa Gly Gln Tyr Xaa Ala Xaa Gly Asp Met Pro Xaa 
        115                 120                 125             


Tyr Gln Ile Arg Ala Pro Xaa Ala Ala Leu Pro Gln Gly Val Val Met 
    130                 135                 140                 


Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu 
145                 150                 155                 160 


Ala Xaa Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala 
                165                 170                 175     


Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser 
            180                 185                 190         


Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu 
        195                 200                 205             


Glu Xaa Leu Lys Asp Ile Cys Ser Pro Lys Xaa Asp Tyr 
    210                 215                 220     


<210> 6930
<211> 345
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<400> 6930
Met Xaa Met Glu Xaa Val Glu Ser Gln His Asp Gly Ser Ile Xaa Ala 
1               5                   10                  15      


Ser Leu Xaa Glu Ser Lys Ser Ala His Val Gln Xaa Gln Xaa Gly Gln 
            20                  25                  30          


Asn Ser Ile Pro Ala Leu Ala Gln Val Ser Val Ala Gly Ser Gly Xaa 
        35                  40                  45              


Arg Arg Gly Ser Pro Ala Val Xaa Leu Val Gln Leu Pro Ser Gly Gln 
    50                  55                  60                  


Xaa Ile His Val Gln Gly Val Ile Gln Xaa Pro Gln Pro Trp Val Ile 
65                  70                  75                  80  


Gln Ser Ser Glu Ile His Xaa Val Gln Val Ala Ala Ile Ala Glu Xaa 
                85                  90                  95      


Asp Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg 
            100                 105                 110         


Glu Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu 
        115                 120                 125             


Ser Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu 
    130                 135                 140                 


Glu Glu Gly Xaa Pro Pro Ser Ile Ala Xaa Met Ala Val Pro Xaa Ser 
145                 150                 155                 160 


Ile Tyr Gln Xaa Ser Xaa Gly Gln Tyr Ile Ala Ile Ala Gln Gly Gly 
                165                 170                 175     


Xaa Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly Leu Gln 
            180                 185                 190         


Ala Leu Xaa Met Xaa Asn Ser Gly Ala Pro Pro Pro Gly Ala Xaa Ile 
        195                 200                 205             


Val Gln Tyr Ala Ala Gln Ser Ala Asp Gly Xaa Gln Gln Phe Phe Val 
    210                 215                 220                 


Pro Gly Ser Gln Val Val Val Gln Asp Glu Glu Xaa Glu Leu Ala Pro 
225                 230                 235                 240 


Ser His Met Ala Ala Ala Xaa Gly Asp Met Pro Xaa Tyr Gln Ile Arg 
                245                 250                 255     


Ala Pro Xaa Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro 
            260                 265                 270         


Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Xaa Arg Lys 
        275                 280                 285             


Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys Arg 
    290                 295                 300                 


Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala Val 
305                 310                 315                 320 


Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Xaa Leu Lys 
                325                 330                 335     


Asp Ile Cys Ser Pro Lys Xaa Asp Tyr 
            340                 345 


<210> 6931
<211> 269
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<400> 6931
Met Xaa Met Glu Xaa Val Glu Ser Gln His Asp Gly Ser Ile Xaa Ala 
1               5                   10                  15      


Ser Leu Xaa Glu Ser Lys Ser Ala His Val Gln Xaa Gln Xaa Gly Gln 
            20                  25                  30          


Asn Ser Ile Pro Ala Leu Ala Gln Val Ser Val Ala Gly Ser Gly Xaa 
        35                  40                  45              


Arg Arg Gly Ser Pro Ala Val Xaa Leu Val Gln Leu Pro Ser Gly Gln 
    50                  55                  60                  


Xaa Ile His Val Gln Gly Val Ile Gln Xaa Pro Gln Pro Trp Val Ile 
65                  70                  75                  80  


Gln Ser Ser Glu Ile His Xaa Val Gln Val Ala Ala Ile Ala Glu Xaa 
                85                  90                  95      


Asp Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg 
            100                 105                 110         


Glu Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu 
        115                 120                 125             


Ser Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu 
    130                 135                 140                 


Glu Glu Gly Xaa Pro Pro Ser Ile Ala Xaa Met Ala Val Pro Xaa Ser 
145                 150                 155                 160 


Ile Tyr Gln Xaa Ser Xaa Gly Gln Tyr Xaa Ala Xaa Gly Asp Met Pro 
                165                 170                 175     


Xaa Tyr Gln Ile Arg Ala Pro Xaa Ala Ala Leu Pro Gln Gly Val Val 
            180                 185                 190         


Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu 
        195                 200                 205             


Glu Ala Xaa Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala 
    210                 215                 220                 


Ala Arg Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu 
225                 230                 235                 240 


Asn Arg Val Ala Val Leu Glu Asn Gln Asn Lys Xaa Leu Ile Glu Glu 
                245                 250                 255     


Leu Lys Ala Leu Lys Asp Leu Tyr Cys His Lys Val Glu 
            260                 265                 


<210> 6932
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 6932
Met Xaa Asn Ser Gly Ala Pro Pro Pro Gly Ala Xaa Ile Val Gln Tyr 
1               5                   10                  15      


Ala Ala Gln Ser Ala Asp Gly Xaa Gln Gln Phe Phe Val Pro Gly Ser 
            20                  25                  30          


Gln Val Val Val Gln Ala Ala Xaa Gly Asp Met Pro Xaa Tyr Gln Ile 
        35                  40                  45              


Arg Ala Pro Xaa Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser 
    50                  55                  60                  


Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Xaa Arg 
65                  70                  75                  80  


Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys 
                85                  90                  95      


Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala 
            100                 105                 110         


Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Xaa Leu 
        115                 120                 125             


Lys Asp Ile Cys Ser Pro Lys Xaa Asp Tyr 
    130                 135             


<210> 6933
<211> 245
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<400> 6933
Met Val Ala Ala Ile Ala Glu Xaa Asp Glu Ser Ala Glu Ser Glu Gly 
1               5                   10                  15      


Val Ile Asp Ser His Lys Arg Arg Glu Ile Leu Ser Arg Arg Pro Ser 
            20                  25                  30          


Tyr Arg Lys Ile Leu Asn Glu Leu Ser Ser Asp Val Pro Gly Val Pro 
        35                  40                  45              


Lys Ile Glu Glu Glu Arg Ser Glu Glu Glu Gly Xaa Pro Pro Ser Ile 
    50                  55                  60                  


Ala Xaa Met Ala Val Pro Xaa Ser Ile Tyr Gln Xaa Ser Xaa Gly Gln 
65                  70                  75                  80  


Tyr Ile Ala Ile Ala Gln Gly Gly Xaa Ile Gln Ile Ser Asn Pro Gly 
                85                  90                  95      


Ser Asp Gly Val Gln Gly Leu Gln Ala Leu Xaa Met Xaa Asn Ser Gly 
            100                 105                 110         


Ala Pro Pro Pro Gly Ala Xaa Ile Val Gln Tyr Ala Ala Gln Ser Ala 
        115                 120                 125             


Asp Gly Xaa Gln Gln Phe Phe Val Pro Gly Ser Gln Val Val Val Gln 
    130                 135                 140                 


Ala Ala Xaa Gly Asp Met Pro Xaa Tyr Gln Ile Arg Ala Pro Xaa Ala 
145                 150                 155                 160 


Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro Gly Ser Leu His 
                165                 170                 175     


Ser Pro Gln Gln Leu Ala Glu Glu Ala Xaa Arg Lys Arg Glu Leu Arg 
            180                 185                 190         


Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys Arg Arg Arg Lys Lys 
        195                 200                 205             


Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala Val Leu Glu Val Gln 
    210                 215                 220                 


Asn Lys Lys Leu Ile Glu Glu Leu Glu Xaa Leu Lys Asp Ile Cys Ser 
225                 230                 235                 240 


Pro Lys Xaa Asp Tyr 
                245 


<210> 6934
<211> 270
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<400> 6934
Met Trp Trp His Gln His Asn Leu Cys Phe Arg Arg Pro Ile Glu Glu 
1               5                   10                  15      


Asp Tyr Ser Ser Gly Asp Val Glu Glu Lys Val Ala Ala Ile Ala Glu 
            20                  25                  30          


Xaa Asp Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg 
        35                  40                  45              


Arg Glu Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu 
    50                  55                  60                  


Leu Ser Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser 
65                  70                  75                  80  


Glu Glu Glu Gly Xaa Pro Pro Ser Ile Ala Xaa Met Ala Val Pro Xaa 
                85                  90                  95      


Ser Ile Tyr Gln Xaa Ser Xaa Gly Gln Tyr Ile Ala Ile Ala Gln Gly 
            100                 105                 110         


Gly Xaa Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly Leu 
        115                 120                 125             


Gln Ala Leu Xaa Met Xaa Asn Ser Gly Ala Pro Pro Pro Gly Ala Xaa 
    130                 135                 140                 


Ile Val Gln Tyr Ala Ala Gln Ser Ala Asp Gly Xaa Gln Gln Phe Phe 
145                 150                 155                 160 


Val Pro Gly Ser Gln Val Val Val Gln Ala Ala Xaa Gly Asp Met Pro 
                165                 170                 175     


Xaa Tyr Gln Ile Arg Ala Pro Xaa Ala Ala Leu Pro Gln Gly Val Val 
            180                 185                 190         


Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu 
        195                 200                 205             


Glu Ala Xaa Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala 
    210                 215                 220                 


Ala Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu 
225                 230                 235                 240 


Ser Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu 
                245                 250                 255     


Leu Glu Xaa Leu Lys Asp Ile Cys Ser Pro Lys Xaa Asp Tyr 
            260                 265                 270 


<210> 6935
<211> 282
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<400> 6935
Met Trp Trp His Gln His Asn Leu Cys Phe Arg Arg Pro Ile Glu Glu 
1               5                   10                  15      


Asp Tyr Ser Ser Gly Asp Val Glu Glu Lys Val Ala Ala Ile Ala Glu 
            20                  25                  30          


Xaa Asp Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg 
        35                  40                  45              


Arg Glu Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu 
    50                  55                  60                  


Leu Ser Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser 
65                  70                  75                  80  


Glu Glu Glu Gly Xaa Pro Pro Ser Ile Ala Xaa Met Ala Val Pro Xaa 
                85                  90                  95      


Ser Ile Tyr Gln Xaa Ser Xaa Gly Gln Tyr Ile Ala Ile Ala Gln Gly 
            100                 105                 110         


Gly Xaa Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly Leu 
        115                 120                 125             


Gln Ala Leu Xaa Met Xaa Asn Ser Gly Ala Pro Pro Pro Gly Ala Xaa 
    130                 135                 140                 


Ile Val Gln Tyr Ala Ala Gln Ser Ala Asp Gly Xaa Gln Gln Phe Phe 
145                 150                 155                 160 


Val Pro Gly Ser Gln Val Val Val Gln Asp Glu Glu Xaa Glu Leu Ala 
                165                 170                 175     


Pro Ser His Met Ala Ala Ala Xaa Gly Asp Met Pro Xaa Tyr Gln Ile 
            180                 185                 190         


Arg Ala Pro Xaa Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser 
        195                 200                 205             


Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Xaa Arg 
    210                 215                 220                 


Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys 
225                 230                 235                 240 


Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala 
                245                 250                 255     


Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Xaa Leu 
            260                 265                 270         


Lys Asp Ile Cys Ser Pro Lys Xaa Asp Tyr 
        275                 280         


<210> 6936
<211> 219
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<400> 6936
Met Trp Trp His Gln His Asn Leu Cys Phe Arg Arg Pro Ile Glu Glu 
1               5                   10                  15      


Asp Tyr Ser Ser Gly Asp Val Glu Glu Lys Val Ala Ala Ile Ala Glu 
            20                  25                  30          


Xaa Asp Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg 
        35                  40                  45              


Arg Glu Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu 
    50                  55                  60                  


Leu Ser Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser 
65                  70                  75                  80  


Glu Glu Glu Gly Xaa Pro Pro Ser Ile Ala Xaa Met Ala Val Pro Xaa 
                85                  90                  95      


Ser Ile Tyr Gln Xaa Ser Xaa Gly Gln Tyr Asn Glu Glu Xaa Glu Leu 
            100                 105                 110         


Ala Pro Ser His Met Ala Ala Ala Xaa Gly Asp Met Pro Xaa Tyr Gln 
        115                 120                 125             


Ile Arg Ala Pro Xaa Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala 
    130                 135                 140                 


Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Xaa 
145                 150                 155                 160 


Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu 
                165                 170                 175     


Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val 
            180                 185                 190         


Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Xaa 
        195                 200                 205             


Leu Lys Asp Ile Cys Ser Pro Lys Xaa Asp Tyr 
    210                 215                 


<210> 6937
<211> 193
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<400> 6937
Val Ala Ala Ile Ala Glu Xaa Asp Glu Ser Ala Glu Ser Glu Gly Val 
1               5                   10                  15      


Ile Asp Ser His Lys Arg Arg Glu Ile Leu Ser Arg Arg Pro Ser Tyr 
            20                  25                  30          


Arg Lys Ile Leu Asn Glu Leu Ser Ser Asp Val Pro Gly Val Pro Lys 
        35                  40                  45              


Ile Glu Glu Glu Arg Ser Glu Glu Glu Gly Xaa Pro Pro Ser Ile Ala 
    50                  55                  60                  


Xaa Met Ala Val Pro Xaa Ser Ile Tyr Gln Xaa Ser Xaa Gly Gln Tyr 
65                  70                  75                  80  


Asn Glu Glu Xaa Glu Leu Ala Pro Ser His Met Ala Ala Ala Xaa Gly 
                85                  90                  95      


Asp Met Pro Xaa Tyr Gln Ile Arg Ala Pro Xaa Ala Ala Leu Pro Gln 
            100                 105                 110         


Gly Val Val Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln 
        115                 120                 125             


Leu Ala Glu Glu Ala Xaa Arg Lys Arg Glu Leu Arg Leu Met Lys Asn 
    130                 135                 140                 


Arg Glu Ala Ala Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys 
145                 150                 155                 160 


Cys Leu Glu Ser Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu 
                165                 170                 175     


Ile Glu Glu Leu Glu Xaa Leu Lys Asp Ile Cys Ser Pro Lys Xaa Asp 
            180                 185                 190         


Tyr 
    


<210> 6938
<211> 53
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<400> 6938
Xaa Asp Gly Ser Ile Xaa Ala Ser Leu Xaa Glu Ser Lys Ser Ala His 
1               5                   10                  15      


Val Gln Xaa Gln Xaa Gly Gln Asn Ser Ile Pro Ala Leu Ala Gln Leu 
            20                  25                  30          


Pro Leu Val Xaa Cys Gln Leu Xaa Arg Ser Glu Leu Leu Leu Leu Leu 
        35                  40                  45              


Cys His Arg Glu Trp 
    50              


<210> 6939
<211> 196
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<400> 6939
Met Arg Leu Pro Leu Leu Val Ser Ala Gly Val Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Pro Cys Pro Pro Cys Arg Ala Leu Leu Ser Arg Gly Pro Val Pro 
            20                  25                  30          


Gly Ala Arg Gln Ala Pro Gln His Pro Gln Pro Leu Asp Phe Phe Gln 
        35                  40                  45              


Pro Pro Pro Gln Ser Glu Gln Pro Gln Gln Pro Gln Ala Arg Pro Val 
    50                  55                  60                  


Leu Leu Arg Met Gly Glu Glu Tyr Phe Leu Arg Leu Gly Asn Leu Asn 
65                  70                  75                  80  


Lys Ser Pro Ala Ala Pro Leu Ser Pro Ala Ser Ser Leu Leu Ala Gly 
                85                  90                  95      


Gly Ser Gly Ser Arg Pro Ser Pro Glu Gln Ala Xaa Ala Asn Phe Phe 
            100                 105                 110         


Arg Val Leu Leu Gln Gln Leu Leu Leu Pro Arg Arg Ser Leu Asp Ser 
        115                 120                 125             


Pro Ala Ala Leu Ala Glu Arg Gly Ala Arg Asn Ala Leu Gly Gly His 
    130                 135                 140                 


Gln Glu Ala Pro Glu Arg Glu Arg Arg Ser Glu Glu Pro Pro Ile Ser 
145                 150                 155                 160 


Leu Asp Leu Xaa Phe His Leu Leu Arg Glu Val Leu Glu Met Ala Arg 
                165                 170                 175     


Ala Glu Gln Leu Ala Gln Gln Ala His Ser Asn Arg Lys Leu Met Glu 
            180                 185                 190         


Ile Ile Gly Lys 
        195     


<210> 6940
<211> 322
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<400> 6940
Met Ser Pro Asn Phe Lys Leu Gln Cys His Phe Ile Leu Ile Phe Leu 
1               5                   10                  15      


Xaa Ala Leu Arg Gly Glu Ser Arg Tyr Leu Glu Leu Arg Glu Ala Ala 
            20                  25                  30          


Asp Tyr Asp Pro Phe Leu Leu Phe Ser Ala Asn Leu Lys Arg Glu Leu 
        35                  40                  45              


Ala Gly Glu Gln Pro Tyr Arg Arg Ala Leu Arg Cys Leu Asp Met Leu 
    50                  55                  60                  


Ser Leu Gln Gly Gln Phe Xaa Phe Xaa Ala Asp Arg Pro Gln Leu His 
65                  70                  75                  80  


Cys Ala Ala Phe Phe Ile Ser Glu Pro Glu Glu Phe Ile Xaa Ile His 
                85                  90                  95      


Tyr Asp Gln Val Ser Ile Asp Cys Gln Gly Gly Asp Phe Leu Lys Val 
            100                 105                 110         


Phe Asp Gly Trp Ile Leu Lys Gly Glu Lys Phe Pro Ser Ser Gln Asp 
        115                 120                 125             


His Pro Leu Pro Ser Ala Glu Arg Tyr Ile Asp Phe Cys Glu Ser Gly 
    130                 135                 140                 


Leu Ser Arg Arg Ser Ile Arg Ser Ser Gln Asn Val Ala Met Ile Phe 
145                 150                 155                 160 


Phe Arg Val His Glu Pro Gly Asn Gly Phe Xaa Leu Xaa Ile Lys Xaa 
                165                 170                 175     


Asp Pro Asn Leu Phe Pro Cys Asn Val Ile Ser Gln Xaa Pro Asn Gly 
            180                 185                 190         


Lys Phe Xaa Leu Val Val Pro His Gln His Arg Asn Cys Ser Phe Ser 
        195                 200                 205             


Ile Ile Tyr Pro Val Val Ile Lys Ile Ser Asp Leu Xaa Leu Gly His 
    210                 215                 220                 


Val Asn Gly Leu Gln Leu Lys Lys Ser Ser Ala Gly Cys Glu Gly Ile 
225                 230                 235                 240 


Gly Asp Phe Val Glu Leu Leu Gly Gly Xaa Gly Leu Asp Pro Ser Lys 
                245                 250                 255     


Met Xaa Pro Leu Ala Asp Leu Cys Tyr Pro Phe His Gly Pro Ala Gln 
            260                 265                 270         


Met Lys Val Gly Cys Asp Asn Xaa Val Val Arg Met Val Ser Ser Gly 
        275                 280                 285             


Lys His Val Asn Arg Val Xaa Phe Glu Tyr Arg Gln Leu Glu Pro Tyr 
    290                 295                 300                 


Glu Leu Glu Asn Pro Asn Gly Asn Ser Ile Gly Glu Phe Cys Leu Ser 
305                 310                 315                 320 


Gly Leu 
        


<210> 6941
<211> 238
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<400> 6941
Met Ser Pro Asn Phe Lys Leu Gln Cys His Phe Ile Leu Ile Phe Leu 
1               5                   10                  15      


Xaa Ala Leu Arg Gly Glu Ser Arg Tyr Leu Glu Leu Arg Glu Ala Ala 
            20                  25                  30          


Asp Tyr Asp Pro Phe Leu Leu Phe Ser Ala Asn Leu Lys Arg Glu Leu 
        35                  40                  45              


Ala Gly Glu Gln Pro Tyr Arg Arg Ala Leu Arg Cys Leu Asp Met Leu 
    50                  55                  60                  


Ser Leu Gln Gly Gln Phe Xaa Phe Xaa Ala Asp Arg Pro Gln Leu His 
65                  70                  75                  80  


Cys Ala Ala Phe Phe Ile Ser Glu Pro Glu Glu Phe Ile Xaa Ile His 
                85                  90                  95      


Tyr Asp Gln Val Ser Ile Asp Cys Gln Gly Gly Asp Phe Leu Lys Val 
            100                 105                 110         


Phe Asp Gly Trp Ile Leu Lys Gly Glu Lys Phe Pro Ser Ser Gln Asp 
        115                 120                 125             


His Pro Leu Pro Ser Ala Glu Arg Tyr Ile Asp Phe Cys Glu Ser Gly 
    130                 135                 140                 


Leu Ser Arg Arg Ser Ile Arg Ser Ser Gln Asn Val Ala Met Ile Phe 
145                 150                 155                 160 


Phe Arg Val His Glu Pro Gly Asn Gly Phe Xaa Leu Xaa Ile Lys Xaa 
                165                 170                 175     


Asp Pro Asn Leu Phe Pro Cys Asn Val Ile Ser Gln Xaa Pro Asn Gly 
            180                 185                 190         


Lys Phe Xaa Leu Val Val Pro His Gln His Arg Asn Cys Ser Phe Ser 
        195                 200                 205             


Ile Ile Tyr Pro Val Val Ile Lys Ile Ser Asp Leu Xaa Leu Gly His 
    210                 215                 220                 


Val Asn Gly Leu Gln Leu Lys Val Ser Cys Leu Leu Val Ser 
225                 230                 235             


<210> 6942
<211> 375
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<400> 6942
Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Asp Asn Gly Tyr Arg Glu Cys Leu 
        35                  40                  45              


Ala Asn Gly Ser Trp Ala Ala Arg Val Asn Tyr Ser Glu Cys Gln Glu 
    50                  55                  60                  


Ile Leu Asn Glu Glu Lys Lys Ser Lys Val His Tyr His Val Ala Val 
65                  70                  75                  80  


Ile Ile Asn Tyr Leu Gly His Cys Ile Ser Leu Val Ala Leu Leu Val 
                85                  90                  95      


Ala Phe Val Leu Phe Leu Arg Leu Arg Ser Ile Arg Cys Leu Arg Asn 
            100                 105                 110         


Ile Ile His Trp Asn Leu Ile Ser Ala Phe Ile Leu Arg Asn Ala Xaa 
        115                 120                 125             


Trp Phe Val Val Gln Leu Xaa Met Ser Pro Glu Val His Gln Ser Asn 
    130                 135                 140                 


Val Gly Trp Cys Arg Leu Val Xaa Ala Ala Tyr Asn Tyr Phe His Val 
145                 150                 155                 160 


Xaa Asn Phe Phe Trp Met Phe Gly Glu Gly Cys Tyr Leu His Xaa Ala 
                165                 170                 175     


Ile Val Leu Xaa Tyr Ser Xaa Asp Arg Leu Arg Lys Trp Met Phe Ile 
            180                 185                 190         


Cys Ile Gly Trp Gly Val Pro Phe Pro Ile Ile Val Ala Trp Ala Ile 
        195                 200                 205             


Gly Lys Leu Tyr Tyr Asp Asn Glu Lys Cys Trp Phe Gly Lys Arg Pro 
    210                 215                 220                 


Gly Val Tyr Xaa Asp Tyr Ile Tyr Gln Gly Pro Met Ile Leu Val Leu 
225                 230                 235                 240 


Leu Ile Asn Phe Ile Phe Leu Phe Asn Ile Val Arg Ile Leu Met Xaa 
                245                 250                 255     


Lys Leu Arg Ala Ser Xaa Xaa Ser Glu Xaa Ile Gln Tyr Arg Lys Ala 
            260                 265                 270         


Val Lys Ala Xaa Leu Val Leu Leu Pro Leu Leu Gly Ile Xaa Tyr Met 
        275                 280                 285             


Leu Phe Phe Val Asn Pro Gly Glu Asp Glu Val Ser Arg Val Val Phe 
    290                 295                 300                 


Ile Tyr Phe Asn Ser Phe Leu Glu Ser Phe Gln Gly Phe Phe Val Ser 
305                 310                 315                 320 


Val Phe Tyr Cys Phe Leu Asn Ser Glu Val Arg Ser Ala Ile Arg Lys 
                325                 330                 335     


Arg Trp His Arg Trp Gln Asp Lys His Ser Ile Arg Ala Arg Val Ala 
            340                 345                 350         


Arg Ala Met Ser Ile Pro Xaa Ser Pro Xaa Arg Val Ser Phe His Ser 
        355                 360                 365             


Ile Lys Gln Ser Xaa Ala Val 
    370                 375 


<210> 6943
<211> 154
<212> PRT
<213> Homo sapiens

<400> 6943
Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Glu Lys Lys Gln Gly Ala Leu Pro 
        35                  40                  45              


Cys Arg Ser His His Gln Leu Pro Gly Pro Leu Tyr Leu Pro Gly Gly 
    50                  55                  60                  


Pro Pro Gly Gly Leu Cys Pro Leu Ser Ala Ala Gln Glu His Pro Val 
65                  70                  75                  80  


Pro Ala Lys His His Pro Leu Glu Pro His Leu Arg Leu His Pro Ala 
                85                  90                  95      


Gln Arg His Leu Val Arg Gly Pro Ala Asn His Glu Pro Arg Gly Pro 
            100                 105                 110         


Pro Glu Gln Arg Gly Leu Val Gln Val Gly Asp Ser Arg Leu Gln Leu 
        115                 120                 125             


Leu Pro Cys Asp Gln Leu Leu Leu Asp Val Arg Arg Gly Leu Leu Pro 
    130                 135                 140                 


Ala His Ser His Arg Ala His Leu Leu His 
145                 150                 


<210> 6944
<211> 186
<212> PRT
<213> Homo sapiens

<400> 6944
Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Glu Lys Lys Gln Gly Ala Leu Pro 
        35                  40                  45              


Cys Arg Ser His His Gln Leu Pro Gly Pro Leu Tyr Leu Pro Gly Gly 
    50                  55                  60                  


Pro Pro Gly Gly Leu Cys Pro Leu Ser Ala Ala Gln Glu His Pro Val 
65                  70                  75                  80  


Pro Ala Lys His His Pro Leu Glu Pro His Leu Arg Leu His Pro Ala 
                85                  90                  95      


Gln Arg His Leu Val Arg Gly Pro Ala Asn His Glu Pro Arg Gly Pro 
            100                 105                 110         


Pro Glu Gln Arg Gly Leu Val Gln Val Gly Asp Ser Arg Leu Gln Leu 
        115                 120                 125             


Leu Pro Cys Asp Gln Leu Leu Leu Asp Val Arg Arg Gly Leu Leu Pro 
    130                 135                 140                 


Ala His Ser His Arg Ala His Leu Leu His Arg Pro Ala Ala Gln Met 
145                 150                 155                 160 


Asp Val His Leu His Trp Leu Gly Cys Ala Leu Pro His His Cys Gly 
                165                 170                 175     


Leu Gly His Trp Glu Ala Val Leu Arg Gln 
            180                 185     


<210> 6945
<211> 430
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<400> 6945
Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Gly Leu Gln Cys Asn Ala Ser Val 
        35                  40                  45              


Asp Leu Ile Gly Xaa Cys Trp Pro Arg Ser Pro Ala Gly Gln Leu Val 
    50                  55                  60                  


Val Arg Pro Cys Pro Ala Phe Phe Tyr Gly Val Arg Tyr Asn Xaa Xaa 
65                  70                  75                  80  


Asn Asn Gly Tyr Arg Glu Cys Leu Ala Asn Gly Ser Trp Ala Ala Arg 
                85                  90                  95      


Val Asn Tyr Ser Glu Cys Gln Glu Ile Leu Asn Glu Glu Lys Lys Ser 
            100                 105                 110         


Lys Val His Tyr His Val Ala Val Ile Ile Asn Tyr Leu Gly His Cys 
        115                 120                 125             


Ile Ser Leu Val Ala Leu Leu Val Ala Phe Val Leu Phe Leu Arg Leu 
    130                 135                 140                 


Arg Pro Gly Cys Xaa His Trp Gly Asp Gln Ala Asp Gly Ala Leu Glu 
145                 150                 155                 160 


Val Gly Ala Pro Trp Ser Gly Ala Pro Phe Gln Val Arg Arg Ser Ile 
                165                 170                 175     


Arg Cys Leu Arg Asn Ile Ile His Trp Asn Leu Ile Ser Ala Phe Ile 
            180                 185                 190         


Leu Arg Asn Ala Xaa Trp Phe Val Val Gln Leu Xaa Met Ser Pro Glu 
        195                 200                 205             


Val His Gln Ser Asn Val Gly Trp Cys Arg Leu Val Xaa Ala Ala Tyr 
    210                 215                 220                 


Asn Tyr Phe His Val Xaa Asn Phe Phe Trp Met Phe Gly Glu Gly Cys 
225                 230                 235                 240 


Tyr Leu His Xaa Ala Ile Val Leu Xaa Tyr Ser Xaa Asp Arg Leu Arg 
                245                 250                 255     


Lys Trp Met Phe Ile Cys Ile Gly Trp Gly Val Pro Phe Pro Ile Ile 
            260                 265                 270         


Val Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Asp Asn Glu Lys Cys Trp 
        275                 280                 285             


Phe Gly Lys Arg Pro Gly Val Tyr Xaa Asp Tyr Ile Tyr Gln Gly Pro 
    290                 295                 300                 


Met Ile Leu Val Leu Leu Ile Asn Phe Ile Phe Leu Phe Asn Ile Val 
305                 310                 315                 320 


Arg Ile Leu Met Xaa Lys Leu Arg Ala Ser Xaa Xaa Ser Glu Xaa Ile 
                325                 330                 335     


Gln Tyr Arg Lys Ala Val Lys Ala Xaa Leu Val Leu Leu Pro Leu Leu 
            340                 345                 350         


Gly Ile Xaa Tyr Met Leu Phe Phe Val Asn Pro Gly Glu Asp Glu Val 
        355                 360                 365             


Ser Arg Val Val Phe Ile Tyr Phe Asn Ser Phe Leu Glu Ser Phe Gln 
    370                 375                 380                 


Val Arg Ser Ala Ile Arg Lys Arg Trp His Arg Trp Gln Asp Lys His 
385                 390                 395                 400 


Ser Ile Arg Ala Arg Val Ala Arg Ala Met Ser Ile Pro Xaa Ser Pro 
                405                 410                 415     


Xaa Arg Val Ser Phe His Ser Ile Lys Gln Ser Xaa Ala Val 
            420                 425                 430 


<210> 6946
<211> 444
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<400> 6946
Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Gly Leu Gln Cys Asn Ala Ser Val 
        35                  40                  45              


Asp Leu Ile Gly Xaa Cys Trp Pro Arg Ser Pro Ala Gly Gln Leu Val 
    50                  55                  60                  


Val Arg Pro Cys Pro Ala Phe Phe Tyr Gly Val Arg Tyr Asn Xaa Xaa 
65                  70                  75                  80  


Asn Asn Gly Tyr Arg Glu Cys Leu Ala Asn Gly Ser Trp Ala Ala Arg 
                85                  90                  95      


Val Asn Tyr Ser Glu Cys Gln Glu Ile Leu Asn Glu Glu Lys Lys Ser 
            100                 105                 110         


Lys Val His Tyr His Val Ala Val Ile Ile Asn Tyr Leu Gly His Cys 
        115                 120                 125             


Ile Ser Leu Val Ala Leu Leu Val Ala Phe Val Leu Phe Leu Arg Leu 
    130                 135                 140                 


Arg Pro Gly Cys Xaa His Trp Gly Asp Gln Ala Asp Gly Ala Leu Glu 
145                 150                 155                 160 


Val Gly Ala Pro Trp Ser Gly Ala Pro Phe Gln Val Arg Arg Ser Ile 
                165                 170                 175     


Arg Cys Leu Arg Asn Ile Ile His Trp Asn Leu Ile Ser Ala Phe Ile 
            180                 185                 190         


Leu Arg Asn Ala Xaa Trp Phe Val Val Gln Leu Xaa Met Ser Pro Glu 
        195                 200                 205             


Val His Gln Ser Asn Val Gly Trp Cys Arg Leu Val Xaa Ala Ala Tyr 
    210                 215                 220                 


Asn Tyr Phe His Val Xaa Asn Phe Phe Trp Met Phe Gly Glu Gly Cys 
225                 230                 235                 240 


Tyr Leu His Xaa Ala Ile Val Leu Xaa Tyr Ser Xaa Asp Arg Leu Arg 
                245                 250                 255     


Lys Trp Met Phe Ile Cys Ile Gly Trp Gly Val Pro Phe Pro Ile Ile 
            260                 265                 270         


Val Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Asp Asn Glu Lys Cys Trp 
        275                 280                 285             


Phe Gly Lys Arg Pro Gly Val Tyr Xaa Asp Tyr Ile Tyr Gln Gly Pro 
    290                 295                 300                 


Met Ile Leu Val Leu Leu Ile Asn Phe Ile Phe Leu Phe Asn Ile Val 
305                 310                 315                 320 


Arg Ile Leu Met Xaa Lys Leu Arg Ala Ser Xaa Xaa Ser Glu Xaa Ile 
                325                 330                 335     


Gln Tyr Arg Lys Ala Val Lys Ala Xaa Leu Val Leu Leu Pro Leu Leu 
            340                 345                 350         


Gly Ile Xaa Tyr Met Leu Phe Phe Val Asn Pro Gly Glu Asp Glu Val 
        355                 360                 365             


Ser Arg Val Val Phe Ile Tyr Phe Asn Ser Phe Leu Glu Ser Phe Gln 
    370                 375                 380                 


Gly Phe Phe Val Ser Val Phe Tyr Cys Phe Leu Asn Ser Glu Val Arg 
385                 390                 395                 400 


Ser Ala Ile Arg Lys Arg Trp His Arg Trp Gln Asp Lys His Ser Ile 
                405                 410                 415     


Arg Ala Arg Val Ala Arg Ala Met Ser Ile Pro Xaa Ser Pro Xaa Arg 
            420                 425                 430         


Val Ser Phe His Ser Ile Lys Gln Ser Xaa Ala Val 
        435                 440                 


<210> 6947
<211> 401
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<400> 6947
Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Gly Leu Gln Cys Asn Ala Ser Val 
        35                  40                  45              


Asp Leu Ile Gly Xaa Cys Trp Pro Arg Ser Pro Ala Gly Gln Leu Val 
    50                  55                  60                  


Val Arg Pro Cys Pro Ala Phe Phe Tyr Gly Val Arg Tyr Asn Xaa Xaa 
65                  70                  75                  80  


Asn Asn Gly Tyr Arg Glu Cys Leu Ala Asn Gly Ser Trp Ala Ala Arg 
                85                  90                  95      


Val Asn Tyr Ser Glu Cys Gln Glu Ile Leu Asn Glu Glu Lys Lys Ser 
            100                 105                 110         


Lys Val His Tyr His Val Ala Val Ile Ile Asn Tyr Leu Gly His Cys 
        115                 120                 125             


Ile Ser Leu Val Ala Leu Leu Val Ala Phe Val Leu Phe Leu Arg Leu 
    130                 135                 140                 


Arg Ser Ile Arg Cys Leu Arg Asn Ile Ile His Trp Asn Leu Ile Ser 
145                 150                 155                 160 


Ala Phe Ile Leu Arg Asn Ala Xaa Trp Phe Val Val Gln Leu Xaa Met 
                165                 170                 175     


Ser Pro Glu Val His Gln Ser Asn Val Gly Trp Cys Arg Leu Val Xaa 
            180                 185                 190         


Ala Ala Tyr Asn Tyr Phe His Val Xaa Asn Phe Phe Trp Met Phe Gly 
        195                 200                 205             


Glu Gly Cys Tyr Leu His Xaa Ala Ile Val Leu Xaa Tyr Ser Xaa Asp 
    210                 215                 220                 


Arg Leu Arg Lys Trp Met Phe Ile Cys Ile Gly Trp Gly Val Pro Phe 
225                 230                 235                 240 


Pro Ile Ile Val Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Asp Asn Glu 
                245                 250                 255     


Lys Cys Trp Phe Gly Lys Arg Pro Gly Val Tyr Xaa Asp Tyr Ile Tyr 
            260                 265                 270         


Gln Gly Pro Met Ile Leu Val Leu Leu Ile Asn Phe Ile Phe Leu Phe 
        275                 280                 285             


Asn Ile Val Arg Ile Leu Met Xaa Lys Leu Arg Ala Ser Xaa Xaa Ser 
    290                 295                 300                 


Glu Xaa Ile Gln Tyr Arg Lys Ala Val Lys Ala Xaa Leu Val Leu Leu 
305                 310                 315                 320 


Pro Leu Leu Gly Ile Xaa Tyr Met Leu Phe Phe Val Asn Pro Gly Glu 
                325                 330                 335     


Asp Glu Val Ser Arg Val Val Phe Ile Tyr Phe Asn Ser Phe Leu Glu 
            340                 345                 350         


Ser Phe Gln Val Arg Ser Ala Ile Arg Lys Arg Trp His Arg Trp Gln 
        355                 360                 365             


Asp Lys His Ser Ile Arg Ala Arg Val Ala Arg Ala Met Ser Ile Pro 
    370                 375                 380                 


Xaa Ser Pro Xaa Arg Val Ser Phe His Ser Ile Lys Gln Ser Xaa Ala 
385                 390                 395                 400 


Val 
    


<210> 6948
<211> 415
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<400> 6948
Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Gly Leu Gln Cys Asn Ala Ser Val 
        35                  40                  45              


Asp Leu Ile Gly Xaa Cys Trp Pro Arg Ser Pro Ala Gly Gln Leu Val 
    50                  55                  60                  


Val Arg Pro Cys Pro Ala Phe Phe Tyr Gly Val Arg Tyr Asn Xaa Xaa 
65                  70                  75                  80  


Asn Asn Gly Tyr Arg Glu Cys Leu Ala Asn Gly Ser Trp Ala Ala Arg 
                85                  90                  95      


Val Asn Tyr Ser Glu Cys Gln Glu Ile Leu Asn Glu Glu Lys Lys Ser 
            100                 105                 110         


Lys Val His Tyr His Val Ala Val Ile Ile Asn Tyr Leu Gly His Cys 
        115                 120                 125             


Ile Ser Leu Val Ala Leu Leu Val Ala Phe Val Leu Phe Leu Arg Leu 
    130                 135                 140                 


Arg Ser Ile Arg Cys Leu Arg Asn Ile Ile His Trp Asn Leu Ile Ser 
145                 150                 155                 160 


Ala Phe Ile Leu Arg Asn Ala Xaa Trp Phe Val Val Gln Leu Xaa Met 
                165                 170                 175     


Ser Pro Glu Val His Gln Ser Asn Val Gly Trp Cys Arg Leu Val Xaa 
            180                 185                 190         


Ala Ala Tyr Asn Tyr Phe His Val Xaa Asn Phe Phe Trp Met Phe Gly 
        195                 200                 205             


Glu Gly Cys Tyr Leu His Xaa Ala Ile Val Leu Xaa Tyr Ser Xaa Asp 
    210                 215                 220                 


Arg Leu Arg Lys Trp Met Phe Ile Cys Ile Gly Trp Gly Val Pro Phe 
225                 230                 235                 240 


Pro Ile Ile Val Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Asp Asn Glu 
                245                 250                 255     


Lys Cys Trp Phe Gly Lys Arg Pro Gly Val Tyr Xaa Asp Tyr Ile Tyr 
            260                 265                 270         


Gln Gly Pro Met Ile Leu Val Leu Leu Ile Asn Phe Ile Phe Leu Phe 
        275                 280                 285             


Asn Ile Val Arg Ile Leu Met Xaa Lys Leu Arg Ala Ser Xaa Xaa Ser 
    290                 295                 300                 


Glu Xaa Ile Gln Tyr Arg Lys Ala Val Lys Ala Xaa Leu Val Leu Leu 
305                 310                 315                 320 


Pro Leu Leu Gly Ile Xaa Tyr Met Leu Phe Phe Val Asn Pro Gly Glu 
                325                 330                 335     


Asp Glu Val Ser Arg Val Val Phe Ile Tyr Phe Asn Ser Phe Leu Glu 
            340                 345                 350         


Ser Phe Gln Gly Phe Phe Val Ser Val Phe Tyr Cys Phe Leu Asn Ser 
        355                 360                 365             


Glu Val Arg Ser Ala Ile Arg Lys Arg Trp His Arg Trp Gln Asp Lys 
    370                 375                 380                 


His Ser Ile Arg Ala Arg Val Ala Arg Ala Met Ser Ile Pro Xaa Ser 
385                 390                 395                 400 


Pro Xaa Arg Val Ser Phe His Ser Ile Lys Gln Ser Xaa Ala Val 
                405                 410                 415 


<210> 6949
<211> 145
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<400> 6949
Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Gly Leu Gln Cys Asn Ala Ser Val 
        35                  40                  45              


Asp Leu Ile Gly Xaa Cys Trp Pro Arg Ser Pro Ala Gly Gln Leu Val 
    50                  55                  60                  


Val Arg Pro Cys Pro Ala Phe Phe Tyr Gly Val Arg Tyr Asn Xaa Xaa 
65                  70                  75                  80  


Asn Asn Gly Tyr Arg Glu Cys Leu Ala Asn Gly Ser Trp Ala Ala Arg 
                85                  90                  95      


Val Asn Tyr Ser Glu Cys Gln Glu Ile Leu Asn Glu Glu Lys Lys Ser 
            100                 105                 110         


Lys Val His Tyr His Val Ala Val Ile Ile Asn Tyr Leu Gly His Cys 
        115                 120                 125             


Ile Ser Leu Val Ala Leu Leu Val Ala Phe Val Leu Phe Leu Arg Leu 
    130                 135                 140                 


Ser 
145 


<210> 6950
<211> 240
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<400> 6950
Met Ser Pro Glu Val His Gln Ser Asn Val Gly Trp Cys Arg Leu Val 
1               5                   10                  15      


Xaa Ala Ala Tyr Asn Tyr Phe His Val Xaa Asn Phe Phe Trp Met Phe 
            20                  25                  30          


Gly Glu Gly Cys Tyr Leu His Xaa Ala Ile Val Leu Xaa Tyr Ser Xaa 
        35                  40                  45              


Asp Arg Leu Arg Lys Trp Met Phe Ile Cys Ile Gly Trp Gly Val Pro 
    50                  55                  60                  


Phe Pro Ile Ile Val Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Asp Asn 
65                  70                  75                  80  


Glu Lys Cys Trp Phe Gly Lys Arg Pro Gly Val Tyr Xaa Asp Tyr Ile 
                85                  90                  95      


Tyr Gln Gly Pro Met Ile Leu Val Leu Leu Ile Asn Phe Ile Phe Leu 
            100                 105                 110         


Phe Asn Ile Val Arg Ile Leu Met Xaa Lys Leu Arg Ala Ser Xaa Xaa 
        115                 120                 125             


Ser Glu Xaa Ile Gln Tyr Arg Lys Ala Val Lys Ala Xaa Leu Val Leu 
    130                 135                 140                 


Leu Pro Leu Leu Gly Ile Xaa Tyr Met Leu Phe Phe Val Asn Pro Gly 
145                 150                 155                 160 


Glu Asp Glu Val Ser Arg Val Val Phe Ile Tyr Phe Asn Ser Phe Leu 
                165                 170                 175     


Glu Ser Phe Gln Gly Phe Phe Val Ser Val Phe Tyr Cys Phe Leu Asn 
            180                 185                 190         


Ser Glu Val Arg Ser Ala Ile Arg Lys Arg Trp His Arg Trp Gln Asp 
        195                 200                 205             


Lys His Ser Ile Arg Ala Arg Val Ala Arg Ala Met Ser Ile Pro Xaa 
    210                 215                 220                 


Ser Pro Xaa Arg Val Ser Phe His Ser Ile Lys Gln Ser Xaa Ala Val 
225                 230                 235                 240 


<210> 6951
<211> 314
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<400> 6951
Met Val Ser Ala Xaa Ile Pro Gln Lys Lys Ser Lys Val His Tyr His 
1               5                   10                  15      


Val Ala Val Ile Ile Asn Tyr Leu Gly His Cys Ile Ser Leu Val Ala 
            20                  25                  30          


Leu Leu Val Ala Phe Val Leu Phe Leu Arg Leu Arg Ser Ile Arg Cys 
        35                  40                  45              


Leu Arg Asn Ile Ile His Trp Asn Leu Ile Ser Ala Phe Ile Leu Arg 
    50                  55                  60                  


Asn Ala Xaa Trp Phe Val Val Gln Leu Xaa Met Ser Pro Glu Val His 
65                  70                  75                  80  


Gln Ser Asn Val Gly Trp Cys Arg Leu Val Xaa Ala Ala Tyr Asn Tyr 
                85                  90                  95      


Phe His Val Xaa Asn Phe Phe Trp Met Phe Gly Glu Gly Cys Tyr Leu 
            100                 105                 110         


His Xaa Ala Ile Val Leu Xaa Tyr Ser Xaa Asp Arg Leu Arg Lys Trp 
        115                 120                 125             


Met Phe Ile Cys Ile Gly Trp Gly Val Pro Phe Pro Ile Ile Val Ala 
    130                 135                 140                 


Trp Ala Ile Gly Lys Leu Tyr Tyr Asp Asn Glu Lys Cys Trp Phe Gly 
145                 150                 155                 160 


Lys Arg Pro Gly Val Tyr Xaa Asp Tyr Ile Tyr Gln Gly Pro Met Ile 
                165                 170                 175     


Leu Val Leu Leu Ile Asn Phe Ile Phe Leu Phe Asn Ile Val Arg Ile 
            180                 185                 190         


Leu Met Xaa Lys Leu Arg Ala Ser Xaa Xaa Ser Glu Xaa Ile Gln Tyr 
        195                 200                 205             


Arg Lys Ala Val Lys Ala Xaa Leu Val Leu Leu Pro Leu Leu Gly Ile 
    210                 215                 220                 


Xaa Tyr Met Leu Phe Phe Val Asn Pro Gly Glu Asp Glu Val Ser Arg 
225                 230                 235                 240 


Val Val Phe Ile Tyr Phe Asn Ser Phe Leu Glu Ser Phe Gln Gly Phe 
                245                 250                 255     


Phe Val Ser Val Phe Tyr Cys Phe Leu Asn Ser Glu Val Arg Ser Ala 
            260                 265                 270         


Ile Arg Lys Arg Trp His Arg Trp Gln Asp Lys His Ser Ile Arg Ala 
        275                 280                 285             


Arg Val Ala Arg Ala Met Ser Ile Pro Xaa Ser Pro Xaa Arg Val Ser 
    290                 295                 300                 


Phe His Ser Ile Lys Gln Ser Xaa Ala Val 
305                 310                 


<210> 6952
<211> 52
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<400> 6952
Xaa Cys Trp Phe Gly Lys Arg Pro Gly Val Tyr Xaa Asp Tyr Ile Tyr 
1               5                   10                  15      


Gln Gly Pro Met Ile Leu Val Leu Leu Glu Gly Cys Glu Ser His Ser 
            20                  25                  30          


Gly Ala Ala Ala Pro Pro Gly His His Leu His Ala Val Leu Arg Gln 
        35                  40                  45              


Ser Arg Gly Gly 
    50          


<210> 6953
<211> 75
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<400> 6953
Xaa Cys Trp Phe Gly Lys Arg Pro Gly Val Tyr Xaa Asp Tyr Ile Tyr 
1               5                   10                  15      


Gln Gly Pro Met Ile Leu Val Leu Leu Ile Asn Phe Ile Phe Leu Phe 
            20                  25                  30          


Asn Ile Val Arg Ile Leu Met Xaa Lys Leu Arg Ala Ser Xaa Xaa Ser 
        35                  40                  45              


Glu Xaa Ile Gln Tyr Arg Ala Ser Leu Cys Leu Cys Ser Xaa Val Ser 
    50                  55                  60                  


Ser Ile Val Arg Ser Val Leu Pro Ser Gly Arg 
65                  70                  75  


<210> 6954
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<400> 6954
Xaa Ser Leu Ala Ser Asn Ile Ser Gly Leu Gln Cys Asn Ala Ser Val 
1               5                   10                  15      


Asp Leu Ile Gly Xaa Cys Trp Pro Arg Ser Pro Ala Gly Gln Leu Val 
            20                  25                  30          


Val Arg Pro Cys Pro Ala Phe Phe Tyr Gly Val Arg Tyr Asn Xaa Xaa 
        35                  40                  45              


Asn Asn Gly Tyr Arg Glu Cys Leu Ala Asn Gly Ser Trp Ala Ala Arg 
    50                  55                  60                  


Val Asn Tyr Ser Glu Cys Gln Glu Ile Leu Asn Glu Glu Glu Pro Gly 
65                  70                  75                  80  


Pro Gln Ala Gln Pro Gly Arg Ala His Arg Gly Gly Xaa 
                85                  90              


<210> 6955
<211> 152
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<400> 6955
Tyr Gly Val Arg Tyr Asn Xaa Xaa Asn Asn Gly Tyr Arg Glu Cys Leu 
1               5                   10                  15      


Ala Asn Gly Ser Trp Ala Ala Arg Val Asn Tyr Ser Glu Cys Gln Glu 
            20                  25                  30          


Ile Leu Asn Glu Glu Lys Lys Ser Lys Val His Tyr His Val Ala Val 
        35                  40                  45              


Ile Ile Asn Tyr Leu Gly His Cys Ile Ser Leu Val Ala Leu Leu Val 
    50                  55                  60                  


Ala Phe Val Leu Phe Leu Arg Leu Arg Ser Ile Arg Cys Leu Arg Asn 
65                  70                  75                  80  


Ile Ile His Trp Asn Leu Ile Ser Ala Phe Ile Leu Arg Asn Ala Xaa 
                85                  90                  95      


Trp Phe Val Val Gln Leu Xaa Met Ser Pro Glu Val His Gln Ser Asn 
            100                 105                 110         


Val Val Cys Pro Ser Pro Ser Leu Trp Pro Gly Pro Leu Gly Ser Cys 
        115                 120                 125             


Xaa Xaa Xaa Met Arg Ser Ala Gly Leu Ala Lys Gly Leu Gly Cys Xaa 
    130                 135                 140                 


Pro Xaa Xaa Ser Xaa Arg Ala Pro 
145                 150         


<210> 6956
<211> 387
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<400> 6956
Met Asp Ala Ala Leu Leu His Ser Leu Leu Glu Ala Asn Cys Ser Leu 
1               5                   10                  15      


Ala Leu Ala Glu Glu Leu Leu Leu Asp Gly Trp Gly Pro Pro Leu Asp 
            20                  25                  30          


Pro Glu Gly Pro Tyr Ser Tyr Cys Asn Xaa Xaa Leu Asp Gln Ile Gly 
        35                  40                  45              


Xaa Cys Trp Pro Arg Ser Ala Ala Gly Ala Leu Val Glu Arg Pro Cys 
    50                  55                  60                  


Pro Glu Tyr Phe Asn Gly Val Lys Tyr Asn Xaa Xaa Arg Asn Ala Tyr 
65                  70                  75                  80  


Arg Glu Cys Leu Glu Asn Gly Xaa Trp Ala Ser Lys Ile Asn Tyr Ser 
                85                  90                  95      


Gln Cys Glu Pro Ile Leu Asp Asp Lys Gln Arg Lys Tyr Asp Leu His 
            100                 105                 110         


Tyr Arg Ile Ala Leu Val Val Asn Tyr Leu Gly His Cys Val Ser Val 
        115                 120                 125             


Ala Ala Leu Val Ala Ala Phe Leu Leu Phe Leu Ala Leu Arg Ser Ile 
    130                 135                 140                 


Arg Cys Leu Arg Asn Val Ile His Trp Asn Leu Ile Xaa Xaa Phe Ile 
145                 150                 155                 160 


Leu Arg Asn Val Met Trp Phe Leu Leu Gln Leu Val Asp His Glu Val 
                165                 170                 175     


His Glu Ser Asn Glu Val Trp Cys Arg Cys Ile Xaa Xaa Ile Phe Asn 
            180                 185                 190         


Tyr Phe Val Val Xaa Asn Phe Phe Trp Met Phe Val Glu Gly Cys Tyr 
        195                 200                 205             


Leu His Xaa Ala Ile Val Met Xaa Tyr Ser Xaa Glu Arg Leu Arg Lys 
    210                 215                 220                 


Cys Leu Phe Leu Phe Ile Gly Trp Cys Ile Pro Phe Pro Ile Ile Val 
225                 230                 235                 240 


Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Glu Asn Glu Gln Cys Trp Phe 
                245                 250                 255     


Gly Lys Glu Pro Gly Asp Leu Val Asp Tyr Ile Tyr Gln Gly Pro Ile 
            260                 265                 270         


Ile Leu Val Leu Leu Ile Asn Phe Val Phe Leu Phe Asn Ile Val Arg 
        275                 280                 285             


Ile Leu Met Xaa Lys Leu Arg Ala Ser Xaa Xaa Ser Glu Xaa Ile Gln 
    290                 295                 300                 


Tyr Arg Lys Ala Val Lys Ala Xaa Leu Val Leu Leu Pro Leu Leu Gly 
305                 310                 315                 320 


Ile Xaa Tyr Met Leu Phe Phe Val Asn Pro Gly Glu Asp Asp Leu Ser 
                325                 330                 335     


Gln Ile Met Phe Ile Tyr Phe Asn Ser Phe Leu Gln Ser Phe Gln Gly 
            340                 345                 350         


Phe Phe Val Ser Val Phe Tyr Cys Phe Phe Asn Gly Glu Ser Trp Val 
        355                 360                 365             


Ser Lys Glu Ala Gln Ala Ala Gly Pro His Gly Arg Glu Lys Pro Glu 
    370                 375                 380                 


Gln Arg Trp 
385         


<210> 6957
<211> 411
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<400> 6957
Met Asp Ala Ala Leu Leu His Ser Leu Leu Glu Ala Asn Cys Ser Leu 
1               5                   10                  15      


Ala Leu Ala Glu Glu Leu Leu Leu Asp Gly Trp Gly Pro Pro Leu Asp 
            20                  25                  30          


Pro Glu Gly Pro Tyr Ser Tyr Cys Asn Xaa Xaa Leu Asp Gln Ile Gly 
        35                  40                  45              


Xaa Cys Trp Pro Arg Ser Ala Ala Gly Ala Leu Val Glu Arg Pro Cys 
    50                  55                  60                  


Pro Glu Tyr Phe Asn Gly Val Lys Tyr Asn Xaa Xaa Arg Asn Ala Tyr 
65                  70                  75                  80  


Arg Glu Cys Leu Glu Asn Gly Xaa Trp Ala Ser Lys Ile Asn Tyr Ser 
                85                  90                  95      


Gln Cys Glu Pro Ile Leu Asp Asp Lys Gln Arg Lys Tyr Asp Leu His 
            100                 105                 110         


Tyr Arg Ile Ala Leu Val Val Asn Tyr Leu Gly His Cys Val Ser Val 
        115                 120                 125             


Ala Ala Leu Val Ala Ala Phe Leu Leu Phe Leu Ala Leu Arg Ser Ile 
    130                 135                 140                 


Arg Cys Leu Arg Asn Val Ile His Trp Asn Leu Ile Xaa Xaa Phe Ile 
145                 150                 155                 160 


Leu Arg Asn Val Met Trp Phe Leu Leu Gln Leu Val Asp His Glu Val 
                165                 170                 175     


His Glu Ser Asn Glu Val Trp Cys Arg Cys Ile Xaa Xaa Ile Phe Asn 
            180                 185                 190         


Tyr Phe Val Val Xaa Asn Phe Phe Trp Met Phe Val Glu Gly Cys Tyr 
        195                 200                 205             


Leu His Xaa Ala Ile Val Met Xaa Tyr Ser Xaa Glu Arg Leu Arg Lys 
    210                 215                 220                 


Cys Leu Phe Leu Phe Ile Gly Trp Cys Ile Pro Phe Pro Ile Ile Val 
225                 230                 235                 240 


Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Glu Asn Glu Gln Cys Trp Phe 
                245                 250                 255     


Gly Lys Glu Pro Gly Asp Leu Val Asp Tyr Ile Tyr Gln Gly Pro Ile 
            260                 265                 270         


Ile Leu Val Leu Leu Ile Asn Phe Val Phe Leu Phe Asn Ile Val Arg 
        275                 280                 285             


Ile Leu Met Xaa Lys Leu Arg Ala Ser Xaa Xaa Ser Glu Xaa Ile Gln 
    290                 295                 300                 


Tyr Arg Lys Ala Val Lys Ala Xaa Leu Val Leu Leu Pro Leu Leu Gly 
305                 310                 315                 320 


Ile Xaa Tyr Met Leu Phe Phe Val Asn Pro Gly Glu Asp Asp Leu Ser 
                325                 330                 335     


Gln Ile Met Phe Ile Tyr Phe Asn Ser Phe Leu Gln Ser Phe Gln Gly 
            340                 345                 350         


Phe Phe Val Ser Val Phe Tyr Cys Phe Phe Asn Gly Glu Val Arg Ser 
        355                 360                 365             


Ala Val Arg Lys Arg Trp His Arg Trp Gln Asp His His Ser Leu Arg 
    370                 375                 380                 


Val Pro Met Ala Arg Ala Met Ser Ile Pro Xaa Ser Pro Xaa Arg Ile 
385                 390                 395                 400 


Ser Phe His Ser Ile Lys Gln Xaa Ala Ala Val 
                405                 410     


<210> 6958
<211> 397
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<400> 6958
Met Gly Arg Glu Pro Trp Pro Glu Asp Arg Asp Leu Gly Phe Pro Gln 
1               5                   10                  15      


Leu Phe Cys Gln Gly Pro Tyr Ser Tyr Cys Asn Xaa Xaa Leu Asp Gln 
            20                  25                  30          


Ile Gly Xaa Cys Trp Pro Arg Ser Ala Ala Gly Ala Leu Val Glu Arg 
        35                  40                  45              


Pro Cys Pro Glu Tyr Phe Asn Gly Val Lys Tyr Asn Xaa Xaa Arg Asn 
    50                  55                  60                  


Ala Tyr Arg Glu Cys Leu Glu Asn Gly Xaa Trp Ala Ser Lys Ile Asn 
65                  70                  75                  80  


Tyr Ser Gln Cys Glu Pro Ile Leu Asp Asp Lys Gln Arg Lys Tyr Asp 
                85                  90                  95      


Leu His Tyr Arg Ile Ala Leu Val Val Asn Tyr Leu Gly His Cys Val 
            100                 105                 110         


Ser Val Ala Ala Leu Val Ala Ala Phe Leu Leu Phe Leu Ala Leu Arg 
        115                 120                 125             


Ser Ile Arg Cys Leu Arg Asn Val Ile His Trp Asn Leu Ile Xaa Xaa 
    130                 135                 140                 


Phe Ile Leu Arg Asn Val Met Trp Phe Leu Leu Gln Leu Val Asp His 
145                 150                 155                 160 


Glu Val His Glu Ser Asn Glu Val Trp Cys Arg Cys Ile Xaa Xaa Ile 
                165                 170                 175     


Phe Asn Tyr Phe Val Val Xaa Asn Phe Phe Trp Met Phe Val Glu Gly 
            180                 185                 190         


Cys Tyr Leu His Xaa Ala Ile Val Met Xaa Tyr Ser Xaa Glu Arg Leu 
        195                 200                 205             


Arg Lys Cys Leu Phe Leu Phe Ile Gly Trp Cys Ile Pro Phe Pro Ile 
    210                 215                 220                 


Ile Val Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Glu Asn Glu Gln Cys 
225                 230                 235                 240 


Trp Phe Gly Lys Glu Pro Gly Asp Leu Val Asp Tyr Ile Tyr Gln Gly 
                245                 250                 255     


Pro Ile Ile Leu Val Leu Leu Ile Asn Phe Val Phe Leu Phe Asn Ile 
            260                 265                 270         


Val Arg Ile Leu Met Xaa Lys Leu Arg Ala Ser Xaa Xaa Ser Glu Xaa 
        275                 280                 285             


Ile Gln Tyr Arg Lys Ala Val Lys Ala Xaa Leu Val Leu Leu Pro Leu 
    290                 295                 300                 


Leu Gly Ile Xaa Tyr Met Leu Phe Phe Val Asn Pro Gly Glu Asp Asp 
305                 310                 315                 320 


Leu Ser Gln Ile Met Phe Ile Tyr Phe Asn Ser Phe Leu Gln Ser Phe 
                325                 330                 335     


Gln Gly Phe Phe Val Ser Val Phe Tyr Cys Phe Phe Asn Gly Glu Val 
            340                 345                 350         


Arg Ser Ala Val Arg Lys Arg Trp His Arg Trp Gln Asp His His Ser 
        355                 360                 365             


Leu Arg Val Pro Met Ala Arg Ala Met Ser Ile Pro Xaa Ser Pro Xaa 
    370                 375                 380                 


Arg Ile Ser Phe His Ser Ile Lys Gln Xaa Ala Ala Val 
385                 390                 395         


<210> 6959
<211> 438
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<400> 6959
Met Arg Gly Pro Ser Gly Pro Pro Gly Leu Leu Tyr Val Pro His Leu 
1               5                   10                  15      


Leu Leu Cys Leu Leu Cys Leu Leu Pro Pro Pro Leu Gln Tyr Ala Ala 
            20                  25                  30          


Gly Gln Ser Gln Met Pro Lys Asp Gln Pro Leu Trp Ala Leu Leu Glu 
        35                  40                  45              


Gln Tyr Cys His Xaa Ile Met Xaa Leu Xaa Asn Leu Ser Gly Pro Tyr 
    50                  55                  60                  


Ser Tyr Cys Asn Xaa Xaa Leu Asp Gln Ile Gly Xaa Cys Trp Pro Arg 
65                  70                  75                  80  


Ser Ala Ala Gly Ala Leu Val Glu Arg Pro Cys Pro Glu Tyr Phe Asn 
                85                  90                  95      


Gly Val Lys Tyr Asn Xaa Xaa Arg Asn Ala Tyr Arg Glu Cys Leu Glu 
            100                 105                 110         


Asn Gly Xaa Trp Ala Ser Lys Ile Asn Tyr Ser Gln Cys Glu Pro Ile 
        115                 120                 125             


Leu Asp Asp Lys Gln Arg Lys Tyr Asp Leu His Tyr Arg Ile Ala Leu 
    130                 135                 140                 


Val Val Asn Tyr Leu Gly His Cys Val Ser Val Ala Ala Leu Val Ala 
145                 150                 155                 160 


Ala Phe Leu Leu Phe Leu Ala Leu Arg Ser Ile Arg Cys Leu Arg Asn 
                165                 170                 175     


Val Ile His Trp Asn Leu Ile Xaa Xaa Phe Ile Leu Arg Asn Val Met 
            180                 185                 190         


Trp Phe Leu Leu Gln Leu Val Asp His Glu Val His Glu Ser Asn Glu 
        195                 200                 205             


Val Trp Cys Arg Cys Ile Xaa Xaa Ile Phe Asn Tyr Phe Val Val Xaa 
    210                 215                 220                 


Asn Phe Phe Trp Met Phe Val Glu Gly Cys Tyr Leu His Xaa Ala Ile 
225                 230                 235                 240 


Val Met Xaa Tyr Ser Xaa Glu Arg Leu Arg Lys Cys Leu Phe Leu Phe 
                245                 250                 255     


Ile Gly Trp Cys Ile Pro Phe Pro Ile Ile Val Ala Trp Ala Ile Gly 
            260                 265                 270         


Lys Leu Tyr Tyr Glu Asn Glu Gln Cys Trp Phe Gly Lys Glu Pro Gly 
        275                 280                 285             


Asp Leu Val Asp Tyr Ile Tyr Gln Gly Pro Ile Ile Leu Val Leu Leu 
    290                 295                 300                 


Ile Asn Phe Val Phe Leu Phe Asn Ile Val Arg Ile Leu Met Xaa Lys 
305                 310                 315                 320 


Leu Arg Ala Ser Xaa Xaa Ser Glu Xaa Ile Gln Tyr Arg Lys Ala Val 
                325                 330                 335     


Lys Ala Xaa Leu Val Leu Leu Pro Leu Leu Gly Ile Xaa Tyr Met Leu 
            340                 345                 350         


Phe Phe Val Asn Pro Gly Glu Asp Asp Leu Ser Gln Ile Met Phe Ile 
        355                 360                 365             


Tyr Phe Asn Ser Phe Leu Gln Ser Phe Gln Gly Phe Phe Val Ser Val 
    370                 375                 380                 


Phe Tyr Cys Phe Phe Asn Gly Glu Val Arg Ser Ala Val Arg Lys Arg 
385                 390                 395                 400 


Trp His Arg Trp Gln Asp His His Ser Leu Arg Val Pro Met Ala Arg 
                405                 410                 415     


Ala Met Ser Ile Pro Xaa Ser Pro Xaa Arg Ile Ser Phe His Ser Ile 
            420                 425                 430         


Lys Gln Xaa Ala Ala Val 
        435             


<210> 6960
<211> 64
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<400> 6960
Met Arg Gly Pro Ser Gly Pro Pro Gly Leu Leu Tyr Val Pro His Leu 
1               5                   10                  15      


Leu Leu Cys Leu Leu Cys Leu Leu Pro Pro Pro Leu Gln Tyr Ala Ala 
            20                  25                  30          


Gly Gln Ser Gln Met Pro Lys Asp Gln Pro Leu Trp Ala Leu Leu Glu 
        35                  40                  45              


Gln Tyr Cys His Xaa Ile Met Xaa Leu Xaa Asn Leu Ser Gly Trp Ser 
    50                  55                  60                  


<210> 6961
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 6961
Met Arg Gly Pro Ser Gly Pro Pro Gly Leu Leu Tyr Val Pro His Leu 
1               5                   10                  15      


Leu Leu Cys Leu Leu Cys Leu Leu Pro Pro Pro Leu Gln Tyr Ala Ala 
            20                  25                  30          


Gly Gln Ser Gln Met Pro Lys Asp Gln Pro Leu Trp Ala Leu Leu Glu 
        35                  40                  45              


Gln Tyr Cys His Xaa Ile Met Xaa Leu Xaa Asn Leu Ser Val Xaa Pro 
    50                  55                  60                  


Gly Ala His Ser His Ser Leu Ser Ala Arg Gly Cys Gly Xaa Arg Trp 
65                  70                  75                  80  


Xaa Arg His Cys Ser Xaa Ala Cys Trp Arg Pro Xaa Ala Ala Trp Arg 
                85                  90                  95      


Trp Leu Lys 
            


<210> 6962
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<400> 6962
Ala Leu Ile Xaa Cys Pro Val Pro Ala Cys Gly Asn Pro Xaa Ile His 
1               5                   10                  15      


Pro Gly Gln Cys Cys Pro Ser Cys Ala Asp Asp Phe Val Val Gln Lys 
            20                  25                  30          


Pro Glu Leu Ser Xaa Pro Ser Ile Cys His Ala Pro Gly Gly Glu Tyr 
        35                  40                  45              


Phe Val Glu Gly Glu Xaa Trp Asn Ile Asp Ser Cys Xaa Gln Cys Xaa 
    50                  55                  60                  


Cys His Ser Gly Arg Val Leu Cys Glu Xaa Glu Val Cys Pro Pro Leu 
65                  70                  75                  80  


Leu Cys Gln Asn Pro Ser Arg Xaa Gln Asp Ser Cys Cys Pro Gln Cys 
                85                  90                  95      


Xaa Asp Gln Pro Phe Arg Pro Ser Leu Ser Arg Asn Asn Ser Val Pro 
            100                 105                 110         


Asn Tyr Cys Lys Asn Asp Glu Gly Asp Ile Phe Leu Ala Ala Glu Ser 
        115                 120                 125             


Trp Lys Pro Asp Val Cys Xaa Ser Cys Ile Cys Ile Asp Ser Val Ile 
    130                 135                 140                 


Ser Cys Phe Ser Glu Ser Cys Pro Ser Val Ser Cys Glu Arg Pro Val 
145                 150                 155                 160 


Leu Arg Lys Gly Gln Cys Cys Pro Tyr Cys Ile Gly Gly Gln Xaa 
                165                 170                 175 


<210> 6963
<211> 222
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<400> 6963
Cys Pro Gly Ser Ile Val Gln Gly Val Cys Gly Cys Cys Tyr Xaa Cys 
1               5                   10                  15      


Ala Ser Gln Arg Asn Glu Ser Cys Gly Gly Xaa Phe Gly Ile Tyr Gly 
            20                  25                  30          


Xaa Cys Asp Arg Gly Leu Arg Cys Val Ile Arg Pro Pro Leu Asn Gly 
        35                  40                  45              


Asp Ser Leu Xaa Glu Tyr Glu Ala Gly Val Cys Glu Glu Glu Lys Pro 
    50                  55                  60                  


Asp Cys Ser Lys Ala Arg Cys Glu Val Gln Phe Ser Pro Arg Cys Pro 
65                  70                  75                  80  


Glu Asp Ser Val Leu Ile Glu Gly Tyr Ala Pro Pro Gly Glu Cys Cys 
                85                  90                  95      


Pro Leu Pro Ser Arg Cys Val Cys Asn Pro Ala Gly Cys Leu Arg Lys 
            100                 105                 110         


Val Cys Gln Pro Gly Asn Leu Asn Ile Leu Val Ser Lys Ala Ser Gly 
        115                 120                 125             


Lys Pro Gly Glu Cys Cys Asp Leu Tyr Glu Cys Lys Pro Val Phe Gly 
    130                 135                 140                 


Val Asp Cys Arg Xaa Val Glu Cys Pro Pro Val Gln Gln Xaa Ala Cys 
145                 150                 155                 160 


Pro Pro Asp Ser Tyr Glu Xaa Gln Val Arg Leu Xaa Ala Asp Gly Cys 
                165                 170                 175     


Cys Xaa Leu Pro Xaa Arg Cys Glu Cys Leu Ser Gly Leu Cys Gly Phe 
            180                 185                 190         


Pro Val Cys Glu Val Gly Ser Xaa Pro Arg Ile Val Ser Arg Gly Asp 
        195                 200                 205             


Gly Xaa Pro Gly Lys Cys Cys Asp Val Phe Glu Cys Val Asn 
    210                 215                 220         


<210> 6964
<211> 1036
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (977)..(977)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (995)..(995)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1035)..(1035)
<223> Selenocysteine

<400> 6964
Met Tyr Leu Val Ala Gly Asp Arg Gly Leu Ala Gly Cys Gly His Leu 
1               5                   10                  15      


Leu Val Ser Leu Leu Gly Leu Leu Leu Leu Leu Ala Arg Ser Gly Xaa 
            20                  25                  30          


Arg Ala Leu Val Cys Leu Pro Cys Asp Glu Ser Lys Cys Glu Glu Pro 
        35                  40                  45              


Arg Asn Cys Pro Gly Ser Ile Val Gln Gly Val Cys Gly Cys Cys Tyr 
    50                  55                  60                  


Xaa Cys Ala Ser Gln Arg Asn Glu Ser Cys Gly Gly Xaa Phe Gly Ile 
65                  70                  75                  80  


Tyr Gly Xaa Cys Asp Arg Gly Leu Arg Cys Val Ile Arg Pro Pro Leu 
                85                  90                  95      


Asn Gly Asp Ser Leu Xaa Glu Tyr Glu Ala Gly Val Cys Glu Asp Glu 
            100                 105                 110         


Asn Trp Xaa Asp Asp Gln Leu Leu Gly Phe Lys Pro Cys Asn Glu Asn 
        115                 120                 125             


Leu Ile Ala Gly Cys Asn Ile Ile Asn Gly Lys Cys Glu Cys Asn Xaa 
    130                 135                 140                 


Ile Arg Xaa Cys Ser Asn Pro Phe Glu Phe Pro Ser Gln Asp Met Cys 
145                 150                 155                 160 


Leu Ser Ala Leu Lys Arg Ile Glu Glu Glu Lys Pro Asp Cys Ser Lys 
                165                 170                 175     


Ala Arg Cys Glu Val Gln Phe Ser Pro Arg Cys Pro Glu Asp Ser Val 
            180                 185                 190         


Leu Ile Glu Gly Tyr Ala Pro Pro Gly Glu Cys Cys Pro Leu Pro Ser 
        195                 200                 205             


Arg Cys Val Cys Asn Pro Ala Gly Cys Leu Arg Lys Val Cys Gln Pro 
    210                 215                 220                 


Gly Asn Leu Asn Ile Leu Val Ser Lys Ala Ser Gly Lys Pro Gly Glu 
225                 230                 235                 240 


Cys Cys Asp Leu Tyr Glu Cys Lys Pro Val Phe Gly Val Asp Cys Arg 
                245                 250                 255     


Xaa Val Glu Cys Pro Pro Val Gln Gln Xaa Ala Cys Pro Pro Asp Ser 
            260                 265                 270         


Tyr Glu Xaa Gln Val Arg Leu Xaa Ala Asp Gly Cys Cys Xaa Leu Pro 
        275                 280                 285             


Xaa Arg Cys Glu Cys Leu Ser Gly Leu Cys Gly Phe Pro Val Cys Glu 
    290                 295                 300                 


Val Gly Ser Xaa Pro Arg Ile Val Ser Arg Gly Asp Gly Xaa Pro Gly 
305                 310                 315                 320 


Lys Cys Cys Asp Val Phe Glu Cys Val Asn Asp Xaa Lys Pro Ala Cys 
                325                 330                 335     


Val Phe Asn Asn Val Glu Tyr Tyr Asp Gly Asp Met Phe Arg Met Asp 
            340                 345                 350         


Asn Cys Arg Phe Cys Arg Cys Gln Gly Gly Val Ala Ile Cys Phe Xaa 
        355                 360                 365             


Ala Gln Cys Gly Glu Ile Asn Cys Glu Arg Tyr Tyr Val Pro Glu Gly 
    370                 375                 380                 


Glu Cys Cys Pro Val Cys Glu Asp Pro Val Tyr Pro Phe Asn Asn Pro 
385                 390                 395                 400 


Ala Gly Cys Tyr Ala Asn Gly Leu Ile Leu Ala His Gly Asp Arg Trp 
                405                 410                 415     


Arg Glu Asp Asp Cys Xaa Phe Cys Gln Cys Val Asn Gly Glu Arg His 
            420                 425                 430         


Cys Val Ala Xaa Val Cys Gly Gln Xaa Cys Xaa Asn Pro Val Lys Val 
        435                 440                 445             


Pro Gly Glu Cys Cys Pro Val Cys Glu Glu Pro Xaa Ile Ile Xaa Val 
    450                 455                 460                 


Asp Pro Pro Ala Cys Gly Glu Leu Ser Asn Cys Xaa Leu Xaa Gly Lys 
465                 470                 475                 480 


Asp Cys Ile Asn Gly Phe Lys Arg Asp His Asn Gly Cys Arg Xaa Cys 
                485                 490                 495     


Gln Cys Ile Asn Xaa Glu Glu Leu Cys Ser Glu Arg Lys Gln Gly Cys 
            500                 505                 510         


Xaa Leu Asn Cys Pro Phe Gly Phe Leu Xaa Asp Ala Gln Asn Cys Glu 
        515                 520                 525             


Ile Cys Glu Cys Arg Pro Arg Pro Lys Lys Cys Arg Pro Ile Ile Cys 
    530                 535                 540                 


Asp Lys Tyr Cys Pro Leu Gly Leu Leu Lys Asn Lys His Gly Cys Asp 
545                 550                 555                 560 


Ile Cys Arg Cys Lys Lys Cys Pro Glu Leu Ser Cys Ser Lys Ile Cys 
                565                 570                 575     


Pro Leu Gly Phe Gln Gln Asp Ser His Gly Cys Leu Ile Cys Lys Cys 
            580                 585                 590         


Arg Glu Ala Ser Ala Ser Ala Gly Pro Pro Ile Leu Ser Gly Xaa Cys 
        595                 600                 605             


Leu Xaa Val Asp Gly His His His Lys Asn Glu Glu Ser Trp His Asp 
    610                 615                 620                 


Gly Cys Arg Glu Cys Tyr Cys Leu Asn Gly Arg Glu Met Cys Ala Leu 
625                 630                 635                 640 


Ile Xaa Cys Pro Val Pro Ala Cys Gly Asn Pro Xaa Ile His Pro Gly 
                645                 650                 655     


Gln Cys Cys Pro Ser Cys Ala Asp Asp Phe Val Val Gln Lys Pro Glu 
            660                 665                 670         


Leu Ser Xaa Pro Ser Ile Cys His Ala Pro Gly Gly Glu Tyr Phe Val 
        675                 680                 685             


Glu Gly Glu Xaa Trp Asn Ile Asp Ser Cys Xaa Gln Cys Xaa Cys His 
    690                 695                 700                 


Ser Gly Arg Val Leu Cys Glu Xaa Glu Val Cys Pro Pro Leu Leu Cys 
705                 710                 715                 720 


Gln Asn Pro Ser Arg Xaa Gln Asp Ser Cys Cys Pro Gln Cys Xaa Asp 
                725                 730                 735     


Gln Pro Phe Arg Pro Ser Leu Ser Arg Asn Asn Ser Val Pro Asn Tyr 
            740                 745                 750         


Cys Lys Asn Asp Glu Gly Asp Ile Phe Leu Ala Ala Glu Ser Trp Lys 
        755                 760                 765             


Pro Asp Val Cys Xaa Ser Cys Ile Cys Ile Asp Ser Val Ile Ser Cys 
    770                 775                 780                 


Phe Ser Glu Ser Cys Pro Ser Val Ser Cys Glu Arg Pro Val Leu Arg 
785                 790                 795                 800 


Lys Gly Gln Cys Cys Pro Tyr Cys Ile Glu Asp Xaa Ile Pro Lys Lys 
                805                 810                 815     


Val Val Cys His Phe Ser Gly Lys Ala Tyr Ala Asp Glu Glu Arg Trp 
            820                 825                 830         


Asp Leu Asp Ser Cys Xaa His Cys Tyr Cys Leu Gln Gly Gln Xaa Leu 
        835                 840                 845             


Cys Ser Xaa Val Ser Cys Pro Pro Leu Pro Cys Val Glu Pro Ile Asn 
    850                 855                 860                 


Val Glu Gly Ser Cys Cys Pro Met Cys Pro Glu Met Tyr Val Pro Glu 
865                 870                 875                 880 


Pro Xaa Asn Ile Pro Ile Glu Lys Xaa Asn His Arg Gly Glu Val Asp 
                885                 890                 895     


Leu Glu Val Pro Leu Trp Pro Xaa Pro Ser Glu Asn Asp Ile Val His 
            900                 905                 910         


Leu Pro Arg Asp Met Gly His Leu Gln Val Asp Tyr Arg Asp Asn Arg 
        915                 920                 925             


Leu His Pro Ser Glu Asp Ser Ser Leu Asp Ser Ile Ala Ser Val Val 
    930                 935                 940                 


Val Pro Ile Ile Ile Cys Leu Ser Ile Ile Ile Ala Phe Leu Phe Ile 
945                 950                 955                 960 


Asn Gln Lys Lys Gln Trp Ile Pro Leu Leu Cys Trp Tyr Arg Xaa Pro 
                965                 970                 975     


Xaa Lys Pro Ser Ser Leu Asn Asn Gln Leu Val Ser Val Asp Cys Lys 
            980                 985                 990         


Lys Gly Xaa Arg Val Gln Val Asp  Ser Ser Gln Arg Met  Leu Arg Ile 
        995                 1000                 1005             


Ala Glu  Pro Asp Ala Arg Phe  Ser Gly Phe Tyr Ser  Met Gln Lys 
    1010                 1015                 1020             


Gln Asn  His Leu Gln Ala Asp  Asn Phe Tyr Gln Xaa  Val 
    1025                 1030                 1035     


<210> 6965
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<400> 6965
Xaa Gly Cys Cys Tyr Xaa Cys Ala Ser Gln Arg Asn Glu Ser Cys Gly 
1               5                   10                  15      


Gly Xaa Phe Gly Ile Tyr Gly Xaa Cys Asp Arg Gly Leu Arg Cys Val 
            20                  25                  30          


Ile Arg Pro Pro Leu Asn Gly Asp Ser Leu Xaa Glu Tyr Glu Ala Gly 
        35                  40                  45              


Val Cys Glu Ala Ala Gly Tyr 
    50                  55  


<210> 6966
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<400> 6966
Met Pro Lys Cys Pro Lys Cys Asn Lys Glu Val Tyr Phe Ala Glu Arg 
1               5                   10                  15      


Val Xaa Ser Leu Gly Lys Asp Trp His Arg Pro Cys Leu Lys Cys Glu 
            20                  25                  30          


Lys Cys Gly Lys Xaa Leu Xaa Ser Gly Gly His Ala Glu His Glu Gly 
        35                  40                  45              


Lys Pro Tyr Cys Asn His Pro Cys Tyr Ala Ala Met Phe Gly Pro Lys 
    50                  55                  60                  


Gly Phe Gly Arg Gly Gly Ala Glu Ser His Xaa Phe Lys 
65                  70                  75          


<210> 6967
<211> 446
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<400> 6967
Met His Glu Pro Ser Leu Cys Ala Asn Val Glu Cys Pro Pro Ala His 
1               5                   10                  15      


Xaa Cys Pro Cys Gly Val Pro Ala Cys Ser Cys Ala His Val Glu Cys 
            20                  25                  30          


Pro Pro Ala His Xaa Cys Arg Cys Gly Val Pro Ala Cys Ser His Met 
        35                  40                  45              


Pro Met Trp Ser Ala Arg Leu Leu Xaa Arg Ala His Val Glu Cys Pro 
    50                  55                  60                  


Pro Ala His Xaa Arg Val His Val Glu Cys Pro Pro Ala His Val Pro 
65                  70                  75                  80  


Met Trp Ser Ala His Leu Leu Xaa Cys Ala Asp Val Glu Cys His Leu 
                85                  90                  95      


Leu Xaa His Val Pro Met Trp Ser Ala Arg Leu Leu Xaa Cys Pro Cys 
            100                 105                 110         


Gly Val Pro Ala Cys Ser His Val Pro Met Arg Ser Ala Arg Leu Leu 
        115                 120                 125             


Xaa Arg Ala His Ala Glu Cys Pro Pro Ala His Xaa Cys Pro Cys Gly 
    130                 135                 140                 


Val Pro Ala Cys Ser His Val Pro Met Arg Ser Ala Arg Leu Leu Xaa 
145                 150                 155                 160 


Arg Ala Asp Val Glu Cys Pro Pro Ala His Xaa Cys Pro Cys Gly Val 
                165                 170                 175     


Pro Ala Cys Ser His Val Pro Xaa Trp Ser Ala Arg Leu Ile Xaa Arg 
            180                 185                 190         


Ala His Val Glu Cys Ser Pro Ala His Xaa Cys Arg Cys Gly Val Pro 
        195                 200                 205             


Ala Cys Ser His Val Pro Met Trp Ser Val Arg Leu Leu Xaa Arg Ala 
    210                 215                 220                 


Asp Ala Glu Cys Pro Pro Ala His Xaa Cys Arg Cys Gly Val Pro Ala 
225                 230                 235                 240 


Cys Ser His Val Pro Met Trp Ser Ala Arg Leu Leu Xaa Cys Arg Cys 
                245                 250                 255     


Gly Val Pro Ala Cys Ser His Val Pro Met Trp Ser Ala Arg Leu Leu 
            260                 265                 270         


Xaa Cys Arg Cys Gly Val Pro Ala Cys Ser His Val Pro Met Trp Ser 
        275                 280                 285             


Ala Arg Leu Leu Xaa Arg Ala His Val Glu Cys Pro Pro Ala His Xaa 
    290                 295                 300                 


Cys Arg Arg Gly Val Pro Ala Cys Ser Arg Ala His Met Glu Cys Pro 
305                 310                 315                 320 


Pro Ala His Xaa Cys His Cys Gly Val Pro Ala Cys Ser His Xaa Cys 
                325                 330                 335     


Arg Cys Gly Val Pro Ala Cys Ser His Val Pro Met Trp Ser Ala Arg 
            340                 345                 350         


Leu Leu Xaa Arg Ala His Val Glu Cys Pro Pro Ala His Xaa Arg Ala 
        355                 360                 365             


His Val Glu Cys Pro Pro Ala His Xaa Cys Pro Cys Gly Val Pro Ala 
    370                 375                 380                 


Cys Ser His Xaa Cys Pro Cys Gly Val Pro Ala Cys Ser His Lys Ala 
385                 390                 395                 400 


Leu Ala Trp Trp Phe Cys Arg Phe Pro Val Leu Pro Ala Glu Ser Asp 
                405                 410                 415     


Ala Val Xaa Val His Ser Xaa His Gly Gly Phe Leu Ile Arg Phe Tyr 
            420                 425                 430         


Val Lys Asp Pro Phe Tyr Ile Ser Leu His Leu Glu Ile Xaa 
        435                 440                 445     


<210> 6968
<211> 304
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<400> 6968
Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Xaa Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Xaa Xaa 
            100                 105                 110         


Xaa Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Asn Gln Glu Gly Ser 
        195                 200                 205             


His Pro Gln Pro Leu Gly Gly Pro Glu Pro Gly Pro Tyr Ala Gln Pro 
    210                 215                 220                 


Ser Val Asn Xaa Pro Leu Pro Asn Leu Gln Asn Gly Pro Ile Tyr Ala 
225                 230                 235                 240 


Arg Val Ile Gln Lys Arg Val Pro Asn Ala Tyr Asp Lys Xaa Ala Leu 
                245                 250                 255     


Ala Leu Glu Val Gly Glu Leu Val Lys Val Xaa Lys Ile Asn Val Ser 
            260                 265                 270         


Gly Gln Trp Glu Gly Glu Cys Asn Gly Lys Arg Gly His Phe Pro Phe 
        275                 280                 285             


Xaa His Val Arg Leu Leu Asp Gln Gln Asn Pro Asp Glu Asp Phe Ser 
    290                 295                 300                 


<210> 6969
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(113)
<223> Selenocysteine

<400> 6969
Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Xaa Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Xaa Xaa 
            100                 105                 110         


Xaa Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Arg 
        195                 200                 


<210> 6970
<211> 223
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(205)
<223> Selenocysteine

<400> 6970
Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Xaa Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Xaa Xaa 
            100                 105                 110         


Xaa Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Glu Cys Tyr Xaa Leu Leu Xaa Leu Ile Tyr Ser 
    130                 135                 140                 


Val Val Leu Phe Ser Phe Trp Asn His Xaa Ile Lys Trp Arg Gln Xaa 
145                 150                 155                 160 


Val Pro Phe His Pro Arg Glu Val Ile Met His Arg Val Asn Ser Ile 
                165                 170                 175     


Lys Gln Asp Cys Phe His Cys Met Glu His Asp Gln Arg Val Xaa His 
            180                 185                 190         


Ser Asp Ile Ser Asp Pro Lys Asn Ser Lys Asn Xaa Xaa Arg Ser Ile 
        195                 200                 205             


Cys Ser Leu Leu Val Asn Ala Ser Tyr Phe Phe Leu Gly Phe Phe 
    210                 215                 220             


<210> 6971
<211> 303
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<400> 6971
Met Ser Ser Ala Arg Phe Asp Ser Ser Asp Arg Ser Ala Trp Tyr Met 
1               5                   10                  15      


Gly Pro Val Ser Arg Gln Glu Ala Gln Xaa Arg Leu Gln Gly Gln Arg 
            20                  25                  30          


His Gly Met Phe Leu Val Arg Asp Ser Ser Xaa Cys Pro Gly Asp Tyr 
        35                  40                  45              


Val Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn 
    50                  55                  60                  


Ser Leu Pro Asn Arg Arg Phe Lys Ile Gly Asp Gln Glu Phe Asp His 
65                  70                  75                  80  


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Xaa Xaa 
                85                  90                  95      


Xaa Leu Ile Glu Pro Ala Pro Arg Tyr Pro Ser Pro Pro Met Gly Ser 
            100                 105                 110         


Val Ser Ala Pro Asn Leu Pro Xaa Ala Glu Asp Asn Leu Glu Tyr Val 
        115                 120                 125             


Arg Xaa Leu Tyr Asp Phe Pro Gly Asn Asp Ala Glu Asp Leu Pro Phe 
    130                 135                 140                 


Lys Lys Gly Glu Ile Leu Val Ile Ile Glu Lys Pro Glu Glu Gln Trp 
145                 150                 155                 160 


Trp Ser Ala Arg Asn Lys Asp Gly Arg Val Gly Met Ile Pro Val Pro 
                165                 170                 175     


Tyr Val Glu Lys Leu Val Arg Ser Ser Pro His Gly Lys His Gly Asn 
            180                 185                 190         


Arg Asn Ser Asn Ser Tyr Gly Ile Pro Glu Pro Ala His Ala Tyr Ala 
        195                 200                 205             


Gln Pro Gln Xaa Xaa Xaa Pro Leu Pro Ala Val Ser Gly Ser Pro Gly 
    210                 215                 220                 


Ala Ala Ile Xaa Pro Leu Pro Ser Xaa Gln Asn Gly Pro Val Phe Ala 
225                 230                 235                 240 


Lys Ala Ile Gln Lys Arg Val Pro Cys Ala Tyr Asp Lys Xaa Ala Leu 
                245                 250                 255     


Ala Leu Glu Val Gly Asp Ile Val Lys Val Xaa Arg Met Asn Ile Asn 
            260                 265                 270         


Gly Gln Trp Glu Gly Glu Val Asn Gly Arg Lys Gly Leu Phe Pro Phe 
        275                 280                 285             


Xaa His Val Lys Ile Phe Asp Pro Gln Asn Pro Asp Glu Asn Glu 
    290                 295                 300             


<210> 6972
<211> 650
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<400> 6972
Met Ala Xaa Ser Asn Asn Pro Arg Lys Phe Ser Glu Lys Ile Ala Leu 
1               5                   10                  15      


His Asn Gln Lys Gln Ala Glu Glu Xaa Ala Ala Phe Glu Glu Val Met 
            20                  25                  30          


Lys Asp Leu Ser Leu Xaa Arg Ala Ala Arg Leu Gln Leu Gln Lys Ser 
        35                  40                  45              


Gln Tyr Leu Gln Leu Gly Pro Ser Arg Gly Gln Tyr Tyr Gly Gly Ser 
    50                  55                  60                  


Leu Pro Asn Val Asn Gln Ile Gly Ser Gly Xaa Met Asp Leu Pro Phe 
65                  70                  75                  80  


Gln Pro Ser Gly Phe Leu Gly Glu Ala Leu Ala Ala Ala Pro Val Ser 
                85                  90                  95      


Leu Xaa Pro Phe Gln Ser Ser Gly Leu Asp Xaa Ser Arg Xaa Xaa Arg 
            100                 105                 110         


His His Gly Leu Val Asp Arg Val Tyr Arg Glu Arg Gly Arg Leu Gly 
        115                 120                 125             


Ser Pro His Arg Arg Pro Leu Ser Val Asp Lys His Gly Arg Gln Ala 
    130                 135                 140                 


Asp Ser Cys Pro Tyr Gly Xaa Met Tyr Leu Ser Pro Pro Ala Asp Xaa 
145                 150                 155                 160 


Ser Trp Arg Arg Xaa Asn Ser Asp Ser Ala Leu His Gln Ser Xaa Met 
                165                 170                 175     


Xaa Pro Xaa Gln Pro Glu Ser Phe Ser Ser Gly Ser Gln Asp Val His 
            180                 185                 190         


Gln Lys Arg Val Leu Leu Leu Xaa Val Pro Gly Met Glu Glu Xaa Xaa 
        195                 200                 205             


Ser Glu Ala Asp Lys Asn Leu Ser Lys Gln Ala Trp Asp Xaa Lys Lys 
    210                 215                 220                 


Xaa Gly Ser Arg Pro Lys Ser Cys Glu Val Pro Gly Ile Asn Ile Phe 
225                 230                 235                 240 


Pro Ser Ala Asp Gln Glu Asn Xaa Xaa Ala Leu Ile Pro Ala Xaa His 
                245                 250                 255     


Asn Xaa Gly Gly Ser Leu Pro Asp Leu Xaa Asn Ile His Phe Pro Ser 
            260                 265                 270         


Pro Leu Pro Xaa Pro Leu Asp Pro Glu Glu Pro Xaa Phe Pro Ala Leu 
        275                 280                 285             


Ser Ser Ser Ser Ser Xaa Gly Asn Leu Ala Ala Asn Leu Xaa His Leu 
    290                 295                 300                 


Gly Ile Gly Gly Ala Gly Gln Gly Met Ser Xaa Pro Gly Ser Ser Pro 
305                 310                 315                 320 


Gln His Arg Pro Ala Gly Val Ser Pro Leu Ser Leu Ser Xaa Glu Ala 
                325                 330                 335     


Arg Arg Gln Gln Ala Ser Pro Xaa Leu Ser Pro Leu Ser Pro Ile Xaa 
            340                 345                 350         


Gln Ala Val Ala Met Asp Ala Leu Ser Leu Glu Gln Gln Leu Pro Tyr 
        355                 360                 365             


Ala Phe Phe Xaa Gln Ala Gly Ser Gln Gln Pro Pro Pro Gln Pro Gln 
    370                 375                 380                 


Pro Pro Pro Pro Pro Pro Pro Ala Ser Gln Gln Pro Pro Pro Pro Pro 
385                 390                 395                 400 


Pro Pro Gln Ala Pro Val Arg Leu Pro Pro Gly Gly Pro Leu Leu Pro 
                405                 410                 415     


Ser Ala Ser Leu Xaa Arg Gly Pro Gln Pro Pro Pro Leu Ala Val Xaa 
            420                 425                 430         


Val Pro Ser Ser Leu Pro Gln Ser Pro Pro Glu Asn Pro Gly Gln Pro 
        435                 440                 445             


Ser Met Gly Ile Asp Ile Ala Ser Ala Pro Ala Leu Gln Gln Tyr Arg 
    450                 455                 460                 


Xaa Ser Ala Gly Ser Pro Ala Asn Gln Ser Pro Xaa Ser Pro Val Ser 
465                 470                 475                 480 


Asn Gln Gly Phe Ser Pro Gly Ser Ser Pro Gln His Xaa Ser Xaa Leu 
                485                 490                 495     


Gly Ser Val Phe Gly Asp Ala Tyr Tyr Glu Gln Gln Met Ala Ala Arg 
            500                 505                 510         


Gln Ala Asn Ala Leu Ser His Gln Leu Glu Gln Phe Asn Met Met Glu 
        515                 520                 525             


Asn Ala Ile Ser Ser Ser Ser Leu Tyr Ser Pro Gly Ser Xaa Leu Asn 
    530                 535                 540                 


Tyr Ser Gln Ala Ala Met Met Gly Leu Xaa Gly Ser His Gly Ser Leu 
545                 550                 555                 560 


Pro Asp Ser Gln Gln Leu Gly Tyr Ala Ser His Ser Gly Ile Pro Asn 
                565                 570                 575     


Ile Ile Leu Xaa Val Xaa Gly Glu Ser Pro Pro Ser Leu Ser Lys Glu 
            580                 585                 590         


Leu Xaa Ser Ser Leu Ala Gly Val Gly Asp Val Ser Phe Asp Ser Asp 
        595                 600                 605             


Ser Gln Phe Pro Leu Asp Glu Leu Lys Ile Asp Pro Leu Xaa Leu Asp 
    610                 615                 620                 


Gly Leu His Met Leu Asn Asp Pro Asp Met Val Leu Ala Asp Pro Ala 
625                 630                 635                 640 


Xaa Glu Asp Xaa Phe Arg Met Asp Arg Leu 
                645                 650 


<210> 6973
<211> 634
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<400> 6973
Met Ala Xaa Ser Asn Asn Pro Arg Lys Phe Ser Glu Lys Ile Ala Leu 
1               5                   10                  15      


His Asn Gln Lys Gln Ala Glu Glu Xaa Ala Ala Phe Glu Glu Val Met 
            20                  25                  30          


Lys Asp Leu Ser Leu Xaa Arg Ala Ala Arg Leu Gln Leu Gln Lys Ser 
        35                  40                  45              


Gln Tyr Leu Gln Leu Gly Pro Ser Arg Gly Gln Tyr Tyr Gly Gly Ser 
    50                  55                  60                  


Leu Pro Asn Val Asn Gln Ile Gly Ser Gly Xaa Met Asp Leu Pro Phe 
65                  70                  75                  80  


Gln Xaa Pro Phe Gln Ser Ser Gly Leu Asp Xaa Ser Arg Xaa Xaa Arg 
                85                  90                  95      


His His Gly Leu Val Asp Arg Val Tyr Arg Glu Arg Gly Arg Leu Gly 
            100                 105                 110         


Ser Pro His Arg Arg Pro Leu Ser Val Asp Lys His Gly Arg Gln Ala 
        115                 120                 125             


Asp Ser Cys Pro Tyr Gly Xaa Met Tyr Leu Ser Pro Pro Ala Asp Xaa 
    130                 135                 140                 


Ser Trp Arg Arg Xaa Asn Ser Asp Ser Ala Leu His Gln Ser Xaa Met 
145                 150                 155                 160 


Xaa Pro Xaa Gln Pro Glu Ser Phe Ser Ser Gly Ser Gln Asp Val His 
                165                 170                 175     


Gln Lys Arg Val Leu Leu Leu Xaa Val Pro Gly Met Glu Glu Xaa Xaa 
            180                 185                 190         


Ser Glu Ala Asp Lys Asn Leu Ser Lys Gln Ala Trp Asp Xaa Lys Lys 
        195                 200                 205             


Xaa Gly Ser Arg Pro Lys Ser Cys Glu Val Pro Gly Ile Asn Ile Phe 
    210                 215                 220                 


Pro Ser Ala Asp Gln Glu Asn Xaa Xaa Ala Leu Ile Pro Ala Xaa His 
225                 230                 235                 240 


Asn Xaa Gly Gly Ser Leu Pro Asp Leu Xaa Asn Ile His Phe Pro Ser 
                245                 250                 255     


Pro Leu Pro Xaa Pro Leu Asp Pro Glu Glu Pro Xaa Phe Pro Ala Leu 
            260                 265                 270         


Ser Ser Ser Ser Ser Xaa Gly Asn Leu Ala Ala Asn Leu Xaa His Leu 
        275                 280                 285             


Gly Ile Gly Gly Ala Gly Gln Gly Met Ser Xaa Pro Gly Ser Ser Pro 
    290                 295                 300                 


Gln His Arg Pro Ala Gly Val Ser Pro Leu Ser Leu Ser Xaa Glu Ala 
305                 310                 315                 320 


Arg Arg Gln Gln Ala Ser Pro Xaa Leu Ser Pro Leu Ser Pro Ile Xaa 
                325                 330                 335     


Gln Ala Val Ala Met Asp Ala Leu Ser Leu Glu Gln Gln Leu Pro Tyr 
            340                 345                 350         


Ala Phe Phe Xaa Gln Ala Gly Ser Gln Gln Pro Pro Pro Gln Pro Gln 
        355                 360                 365             


Pro Pro Pro Pro Pro Pro Pro Ala Ser Gln Gln Pro Pro Pro Pro Pro 
    370                 375                 380                 


Pro Pro Gln Ala Pro Val Arg Leu Pro Pro Gly Gly Pro Leu Leu Pro 
385                 390                 395                 400 


Ser Ala Ser Leu Xaa Arg Gly Pro Gln Pro Pro Pro Leu Ala Val Xaa 
                405                 410                 415     


Val Pro Ser Ser Leu Pro Gln Ser Pro Pro Glu Asn Pro Gly Gln Pro 
            420                 425                 430         


Ser Met Gly Ile Asp Ile Ala Ser Ala Pro Ala Leu Gln Gln Tyr Arg 
        435                 440                 445             


Xaa Ser Ala Gly Ser Pro Ala Asn Gln Ser Pro Xaa Ser Pro Val Ser 
    450                 455                 460                 


Asn Gln Gly Phe Ser Pro Gly Ser Ser Pro Gln His Xaa Ser Xaa Leu 
465                 470                 475                 480 


Gly Ser Val Phe Gly Asp Ala Tyr Tyr Glu Gln Gln Met Ala Ala Arg 
                485                 490                 495     


Gln Ala Asn Ala Leu Ser His Gln Leu Glu Gln Phe Asn Met Met Glu 
            500                 505                 510         


Asn Ala Ile Ser Ser Ser Ser Leu Tyr Ser Pro Gly Ser Xaa Leu Asn 
        515                 520                 525             


Tyr Ser Gln Ala Ala Met Met Gly Leu Xaa Gly Ser His Gly Ser Leu 
    530                 535                 540                 


Pro Asp Ser Gln Gln Leu Gly Tyr Ala Ser His Ser Gly Ile Pro Asn 
545                 550                 555                 560 


Ile Ile Leu Xaa Val Xaa Gly Glu Ser Pro Pro Ser Leu Ser Lys Glu 
                565                 570                 575     


Leu Xaa Ser Ser Leu Ala Gly Val Gly Asp Val Ser Phe Asp Ser Asp 
            580                 585                 590         


Ser Gln Phe Pro Leu Asp Glu Leu Lys Ile Asp Pro Leu Xaa Leu Asp 
        595                 600                 605             


Gly Leu His Met Leu Asn Asp Pro Asp Met Val Leu Ala Asp Pro Ala 
    610                 615                 620                 


Xaa Glu Asp Xaa Phe Arg Met Asp Arg Leu 
625                 630                 


<210> 6974
<211> 392
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<400> 6974
Met Asp Leu Pro Phe Gln Xaa Pro Phe Gln Ser Ser Gly Leu Asp Xaa 
1               5                   10                  15      


Ser Arg Xaa Xaa Arg His His Gly Leu Val Asp Arg Val Tyr Arg Glu 
            20                  25                  30          


Arg Gly Arg Leu Gly Ser Pro His Arg Arg Pro Leu Ser Val Asp Lys 
        35                  40                  45              


His Gly Arg Gln Ala Asp Ser Cys Pro Tyr Gly Xaa Met Tyr Leu Ser 
    50                  55                  60                  


Pro Pro Ala Asp Xaa Ser Trp Arg Arg Xaa Asn Ser Asp Ser Ala Leu 
65                  70                  75                  80  


His Gln Ser Xaa Met Xaa Pro Xaa Gln Pro Glu Ser Phe Ser Ser Gly 
                85                  90                  95      


Ser Gln Asp Val His Gln Lys Arg Val Leu Leu Leu Xaa Val Pro Gly 
            100                 105                 110         


Met Glu Glu Xaa Xaa Ser Glu Ala Asp Lys Asn Leu Ser Lys Gln Ala 
        115                 120                 125             


Trp Asp Xaa Lys Lys Xaa Gly Ser Arg Pro Lys Ser Cys Glu Val Pro 
    130                 135                 140                 


Gly Ile Asn Ile Phe Pro Ser Ala Asp Gln Glu Asn Xaa Xaa Ala Leu 
145                 150                 155                 160 


Ile Pro Ala Xaa His Asn Xaa Gly Gly Ser Leu Pro Asp Leu Xaa Asn 
                165                 170                 175     


Ile His Phe Pro Ser Pro Leu Pro Xaa Pro Leu Asp Pro Glu Glu Pro 
            180                 185                 190         


Xaa Phe Pro Ala Leu Ser Ser Ser Ser Ser Xaa Gly Asn Leu Ala Ala 
        195                 200                 205             


Asn Leu Xaa His Leu Gly Ile Gly Gly Ala Gly Gln Gly Met Ser Xaa 
    210                 215                 220                 


Pro Gly Ser Ser Pro Gln His Arg Pro Ala Gly Val Ser Pro Leu Ser 
225                 230                 235                 240 


Leu Ser Xaa Glu Ala Arg Arg Gln Gln Ala Ser Pro Xaa Leu Ser Pro 
                245                 250                 255     


Leu Ser Pro Ile Xaa Gln Leu Glu Gln Phe Asn Met Met Glu Asn Ala 
            260                 265                 270         


Ile Ser Ser Ser Ser Leu Tyr Ser Pro Gly Ser Xaa Leu Asn Tyr Ser 
        275                 280                 285             


Gln Ala Ala Met Met Gly Leu Xaa Gly Ser His Gly Ser Leu Pro Asp 
    290                 295                 300                 


Ser Gln Gln Leu Gly Tyr Ala Ser His Ser Gly Ile Pro Asn Ile Ile 
305                 310                 315                 320 


Leu Xaa Val Xaa Gly Glu Ser Pro Pro Ser Leu Ser Lys Glu Leu Xaa 
                325                 330                 335     


Ser Ser Leu Ala Gly Val Gly Asp Val Ser Phe Asp Ser Asp Ser Gln 
            340                 345                 350         


Phe Pro Leu Asp Glu Leu Lys Ile Asp Pro Leu Xaa Leu Asp Gly Leu 
        355                 360                 365             


His Met Leu Asn Asp Pro Asp Met Val Leu Ala Asp Pro Ala Xaa Glu 
    370                 375                 380                 


Asp Xaa Phe Arg Met Asp Arg Leu 
385                 390         


<210> 6975
<211> 593
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<400> 6975
Met Leu Gln Leu Gln Lys Ser Gln Tyr Leu Gln Leu Gly Pro Ser Arg 
1               5                   10                  15      


Gly Gln Tyr Tyr Gly Gly Ser Leu Pro Asn Val Asn Gln Ile Gly Ser 
            20                  25                  30          


Gly Xaa Met Asp Leu Pro Phe Gln Xaa Pro Phe Gln Ser Ser Gly Leu 
        35                  40                  45              


Asp Xaa Ser Arg Xaa Xaa Arg His His Gly Leu Val Asp Arg Val Tyr 
    50                  55                  60                  


Arg Glu Arg Gly Arg Leu Gly Ser Pro His Arg Arg Pro Leu Ser Val 
65                  70                  75                  80  


Asp Lys His Gly Arg Gln Ala Asp Ser Cys Pro Tyr Gly Xaa Met Tyr 
                85                  90                  95      


Leu Ser Pro Pro Ala Asp Xaa Ser Trp Arg Arg Xaa Asn Ser Asp Ser 
            100                 105                 110         


Ala Leu His Gln Ser Xaa Met Xaa Pro Xaa Gln Pro Glu Ser Phe Ser 
        115                 120                 125             


Ser Gly Ser Gln Asp Val His Gln Lys Arg Val Leu Leu Leu Xaa Val 
    130                 135                 140                 


Pro Gly Met Glu Glu Xaa Xaa Ser Glu Ala Asp Lys Asn Leu Ser Lys 
145                 150                 155                 160 


Gln Ala Trp Asp Xaa Lys Lys Xaa Gly Ser Arg Pro Lys Ser Cys Glu 
                165                 170                 175     


Val Pro Gly Ile Asn Ile Phe Pro Ser Ala Asp Gln Glu Asn Xaa Xaa 
            180                 185                 190         


Ala Leu Ile Pro Ala Xaa His Asn Xaa Gly Gly Ser Leu Pro Asp Leu 
        195                 200                 205             


Xaa Asn Ile His Phe Pro Ser Pro Leu Pro Xaa Pro Leu Asp Pro Glu 
    210                 215                 220                 


Glu Pro Xaa Phe Pro Ala Leu Ser Ser Ser Ser Ser Xaa Gly Asn Leu 
225                 230                 235                 240 


Ala Ala Asn Leu Xaa His Leu Gly Ile Gly Gly Ala Gly Gln Gly Met 
                245                 250                 255     


Ser Xaa Pro Gly Ser Ser Pro Gln His Arg Pro Ala Gly Val Ser Pro 
            260                 265                 270         


Leu Ser Leu Ser Xaa Glu Ala Arg Arg Gln Gln Ala Ser Pro Xaa Leu 
        275                 280                 285             


Ser Pro Leu Ser Pro Ile Xaa Gln Ala Val Ala Met Asp Ala Leu Ser 
    290                 295                 300                 


Leu Glu Gln Gln Leu Pro Tyr Ala Phe Phe Xaa Gln Ala Gly Ser Gln 
305                 310                 315                 320 


Gln Pro Pro Pro Gln Pro Gln Pro Pro Pro Pro Pro Pro Pro Ala Ser 
                325                 330                 335     


Gln Gln Pro Pro Pro Pro Pro Pro Pro Gln Ala Pro Val Arg Leu Pro 
            340                 345                 350         


Pro Gly Gly Pro Leu Leu Pro Ser Ala Ser Leu Xaa Arg Gly Pro Gln 
        355                 360                 365             


Pro Pro Pro Leu Ala Val Xaa Val Pro Ser Ser Leu Pro Gln Ser Pro 
    370                 375                 380                 


Pro Glu Asn Pro Gly Gln Pro Ser Met Gly Ile Asp Ile Ala Ser Ala 
385                 390                 395                 400 


Pro Ala Leu Gln Gln Tyr Arg Xaa Ser Ala Gly Ser Pro Ala Asn Gln 
                405                 410                 415     


Ser Pro Xaa Ser Pro Val Ser Asn Gln Gly Phe Ser Pro Gly Ser Ser 
            420                 425                 430         


Pro Gln His Xaa Ser Xaa Leu Gly Ser Val Phe Gly Asp Ala Tyr Tyr 
        435                 440                 445             


Glu Gln Gln Met Ala Ala Arg Gln Ala Asn Ala Leu Ser His Gln Leu 
    450                 455                 460                 


Glu Gln Phe Asn Met Met Glu Asn Ala Ile Ser Ser Ser Ser Leu Tyr 
465                 470                 475                 480 


Ser Pro Gly Ser Xaa Leu Asn Tyr Ser Gln Ala Ala Met Met Gly Leu 
                485                 490                 495     


Xaa Gly Ser His Gly Ser Leu Pro Asp Ser Gln Gln Leu Gly Tyr Ala 
            500                 505                 510         


Ser His Ser Gly Ile Pro Asn Ile Ile Leu Xaa Val Xaa Gly Glu Ser 
        515                 520                 525             


Pro Pro Ser Leu Ser Lys Glu Leu Xaa Ser Ser Leu Ala Gly Val Gly 
    530                 535                 540                 


Asp Val Ser Phe Asp Ser Asp Ser Gln Phe Pro Leu Asp Glu Leu Lys 
545                 550                 555                 560 


Ile Asp Pro Leu Xaa Leu Asp Gly Leu His Met Leu Asn Asp Pro Asp 
                565                 570                 575     


Met Val Leu Ala Asp Pro Ala Xaa Glu Asp Xaa Phe Arg Met Asp Arg 
            580                 585                 590         


Leu 
    


<210> 6976
<211> 54
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 6976
Met Ala Xaa Ser Gly Ala Asn Gly Pro Gly Ser Ala Xaa Ala Ser Ala 
1               5                   10                  15      


Ser Asn Pro Arg Lys Phe Ser Glu Lys Ile Ala Leu Gln Lys Gln Arg 
            20                  25                  30          


Gln Ala Glu Glu Xaa Ala Ala Phe Glu Glu Val Met Met Asp Ile Gly 
        35                  40                  45              


Ser Xaa Arg Asp Lys Leu 
    50                  


<210> 6977
<211> 693
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<400> 6977
Met Ala Xaa Ser Gly Ala Asn Gly Pro Gly Ser Ala Xaa Ala Ser Ala 
1               5                   10                  15      


Ser Asn Pro Arg Lys Phe Ser Glu Lys Ile Ala Leu Gln Lys Gln Arg 
            20                  25                  30          


Gln Ala Glu Glu Xaa Ala Ala Phe Glu Glu Val Met Met Asp Ile Gly 
        35                  40                  45              


Ser Xaa Arg Leu Gln Ala Gln Lys Leu Arg Leu Ala Tyr Xaa Arg Ser 
    50                  55                  60                  


Ser His Tyr Gly Gly Ser Leu Pro Asn Val Asn Gln Ile Gly Ser Gly 
65                  70                  75                  80  


Leu Ala Glu Phe Gln Ser Pro Leu His Ser Pro Leu Asp Ser Ser Arg 
                85                  90                  95      


Ser Xaa Arg His His Gly Leu Val Glu Arg Val Gln Arg Asp Pro Arg 
            100                 105                 110         


Arg Met Val Ser Pro Leu Arg Arg Tyr Xaa Arg His Ile Asp Ser Ser 
        115                 120                 125             


Pro Tyr Ser Pro Ala Tyr Leu Ser Pro Pro Pro Glu Ser Ser Trp Arg 
    130                 135                 140                 


Arg Xaa Met Ala Trp Gly Asn Phe Pro Ala Glu Lys Gly Gln Leu Phe 
145                 150                 155                 160 


Arg Leu Pro Ser Ala Leu Asn Arg Xaa Ser Ser Asp Ser Ala Leu His 
                165                 170                 175     


Xaa Ser Val Met Asn Pro Ser Pro Gln Asp Xaa Tyr Pro Gly Pro Xaa 
            180                 185                 190         


Pro Pro Ser Ile Leu Pro Ser Arg Arg Gly Gly Ile Leu Asp Gly Glu 
        195                 200                 205             


Met Asp Pro Lys Val Pro Ala Ile Glu Glu Asn Leu Leu Asp Asp Lys 
    210                 215                 220                 


His Leu Leu Lys Pro Trp Asp Ala Lys Lys Leu Ser Ser Ser Ser Ser 
225                 230                 235                 240 


Arg Pro Arg Ser Cys Glu Val Pro Gly Ile Asn Ile Phe Pro Ser Pro 
                245                 250                 255     


Asp Gln Pro Ala Asn Val Pro Val Leu Pro Pro Ala Met Asn Xaa Gly 
            260                 265                 270         


Gly Ser Leu Pro Asp Leu Xaa Asn Leu His Phe Pro Pro Pro Leu Pro 
        275                 280                 285             


Xaa Pro Leu Asp Pro Glu Glu Xaa Ala Tyr Pro Ser Leu Ser Gly Gly 
    290                 295                 300                 


Asn Ser Xaa Ser Asn Leu Xaa His Xaa Met Xaa His Leu Gly Ile Ser 
305                 310                 315                 320 


Arg Gly Met Gly Leu Gly Pro Gly Tyr Asp Ala Pro Gly Leu His Ser 
                325                 330                 335     


Pro Leu Ser His Pro Ser Leu Gln Ser Ser Leu Ser Asn Pro Asn Leu 
            340                 345                 350         


Gln Ala Ser Leu Ser Ser Pro Gln Pro Gln Leu Gln Gly Ser His Ser 
        355                 360                 365             


His Pro Ser Leu Pro Ala Ser Ser Leu Ala Arg His Val Leu Pro Xaa 
    370                 375                 380                 


Xaa Ser Leu Gly His Pro Ser Leu Ser Ala Pro Ala Leu Ser Ser Ser 
385                 390                 395                 400 


Ser Ser Ser Ser Ser Xaa Ser Ser Pro Val Leu Gly Ala Pro Ser Tyr 
                405                 410                 415     


Pro Ala Ser Xaa Pro Gly Ala Ser Pro His His Arg Arg Val Pro Leu 
            420                 425                 430         


Ser Pro Leu Ser Leu Leu Ala Gly Pro Ala Asp Ala Arg Arg Ser Gln 
        435                 440                 445             


Gln Gln Leu Pro Lys Gln Phe Ser Pro Xaa Met Ser Pro Xaa Leu Ser 
    450                 455                 460                 


Ser Ile Xaa Gln Gly Val Pro Leu Asp Xaa Ser Lys Leu Ser Xaa Asp 
465                 470                 475                 480 


Gln Arg Leu Pro Pro Tyr Pro Tyr Ser Ser Pro Ser Leu Val Leu Pro 
                485                 490                 495     


Xaa Gln Pro His Xaa Pro Lys Ser Leu Gln Gln Pro Gly Leu Pro Ser 
            500                 505                 510         


Gln Ser Cys Ser Val Gln Ser Ser Gly Gly Gln Pro Pro Gly Arg Gln 
        515                 520                 525             


Ser His Tyr Gly Xaa Pro Tyr Pro Pro Gly Pro Ser Gly His Gly Gln 
    530                 535                 540                 


Gln Ser Tyr His Arg Pro Met Ser Asp Phe Asn Leu Gly Asn Leu Glu 
545                 550                 555                 560 


Gln Phe Ser Met Glu Ser Pro Ser Ala Ser Leu Val Leu Asp Pro Pro 
                565                 570                 575     


Gly Phe Ser Glu Gly Pro Gly Phe Leu Gly Gly Glu Gly Pro Met Gly 
            580                 585                 590         


Gly Pro Gln Asp Pro His Xaa Phe Asn His Gln Asn Leu Xaa His Cys 
        595                 600                 605             


Ser Arg His Gly Ser Gly Pro Asn Ile Ile Leu Xaa Gly Asp Ser Ser 
    610                 615                 620                 


Pro Gly Phe Ser Lys Glu Ile Ala Ala Ala Leu Ala Gly Val Pro Gly 
625                 630                 635                 640 


Phe Glu Val Ser Ala Ala Gly Leu Glu Leu Gly Leu Gly Leu Glu Asp 
                645                 650                 655     


Glu Leu Arg Met Glu Pro Leu Gly Leu Glu Gly Leu Asn Met Leu Ser 
            660                 665                 670         


Asp Pro Cys Ala Leu Leu Pro Asp Pro Ala Val Glu Glu Ser Phe Arg 
        675                 680                 685             


Ser Asp Arg Leu Gln 
    690             


<210> 6978
<211> 373
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<400> 6978
Met Ala Xaa Ser Gly Ala Asn Gly Pro Gly Ser Ala Xaa Ala Ser Ala 
1               5                   10                  15      


Ser Asn Pro Arg Lys Phe Ser Glu Lys Ile Ala Leu Gln Lys Gln Arg 
            20                  25                  30          


Gln Ala Ser Leu Ser Ser Pro Gln Pro Gln Leu Gln Gly Ser His Ser 
        35                  40                  45              


His Pro Ser Leu Pro Ala Ser Ser Leu Ala Arg His Val Leu Pro Xaa 
    50                  55                  60                  


Xaa Ser Leu Gly His Pro Ser Leu Ser Ala Pro Ala Leu Ser Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Ser Xaa Ser Ser Pro Val Leu Gly Ala Pro Ser Tyr 
                85                  90                  95      


Pro Ala Ser Xaa Pro Gly Ala Ser Pro His His Arg Arg Val Pro Leu 
            100                 105                 110         


Ser Pro Leu Ser Leu Leu Ala Gly Pro Ala Asp Ala Arg Arg Ser Gln 
        115                 120                 125             


Gln Gln Leu Pro Lys Gln Phe Ser Pro Xaa Met Ser Pro Xaa Leu Ser 
    130                 135                 140                 


Ser Ile Xaa Gln Gly Val Pro Leu Asp Xaa Ser Lys Leu Ser Xaa Asp 
145                 150                 155                 160 


Gln Arg Leu Pro Pro Tyr Pro Tyr Ser Ser Pro Ser Leu Val Leu Pro 
                165                 170                 175     


Xaa Gln Pro His Xaa Pro Lys Ser Leu Gln Gln Pro Gly Leu Pro Ser 
            180                 185                 190         


Gln Ser Cys Ser Val Gln Ser Ser Gly Gly Gln Pro Pro Gly Arg Gln 
        195                 200                 205             


Ser His Tyr Gly Xaa Pro Tyr Pro Pro Gly Pro Ser Gly His Gly Gln 
    210                 215                 220                 


Gln Ser Tyr His Arg Pro Met Ser Asp Phe Asn Leu Gly Asn Leu Glu 
225                 230                 235                 240 


Gln Phe Ser Met Glu Ser Pro Ser Ala Ser Leu Val Leu Asp Pro Pro 
                245                 250                 255     


Gly Phe Ser Glu Gly Pro Gly Phe Leu Gly Gly Glu Gly Pro Met Gly 
            260                 265                 270         


Gly Pro Gln Asp Pro His Xaa Phe Asn His Gln Asn Leu Xaa His Cys 
        275                 280                 285             


Ser Arg His Gly Ser Gly Pro Asn Ile Ile Leu Xaa Gly Asp Ser Ser 
    290                 295                 300                 


Pro Gly Phe Ser Lys Glu Ile Ala Ala Ala Leu Ala Gly Val Pro Gly 
305                 310                 315                 320 


Phe Glu Val Ser Ala Ala Gly Leu Glu Leu Gly Leu Gly Leu Glu Asp 
                325                 330                 335     


Glu Leu Arg Met Glu Pro Leu Gly Leu Glu Gly Leu Asn Met Leu Ser 
            340                 345                 350         


Asp Pro Cys Ala Leu Leu Pro Asp Pro Ala Val Glu Glu Ser Phe Arg 
        355                 360                 365             


Ser Asp Arg Leu Gln 
    370             


<210> 6979
<211> 481
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<400> 6979
Ser Pro Leu His Ser Pro Leu Asp Ser Ser Arg Ser Xaa Arg His His 
1               5                   10                  15      


Gly Leu Val Glu Arg Val Gln Arg Asp Pro Arg Arg Met Val Ser Pro 
            20                  25                  30          


Leu Arg Arg Tyr Xaa Arg His Ile Asp Ser Ser Pro Tyr Ser Pro Ala 
        35                  40                  45              


Tyr Leu Ser Pro Pro Pro Glu Ser Ser Trp Arg Arg Xaa Met Ala Trp 
    50                  55                  60                  


Gly Asn Phe Pro Ala Glu Lys Gly Gln Leu Phe Arg Leu Pro Ser Ala 
65                  70                  75                  80  


Leu Asn Arg Xaa Ser Ser Asp Ser Ala Leu His Xaa Ser Val Met Asn 
                85                  90                  95      


Pro Ser Pro Gln Asp Xaa Tyr Pro Gly Pro Xaa Pro Pro Ser Ile Leu 
            100                 105                 110         


Pro Ser Arg Arg Gly Gly Ile Leu Asp Gly Glu Met Asp Pro Lys Val 
        115                 120                 125             


Phe Leu Phe Gln Val Pro Ala Ile Glu Glu Asn Leu Leu Asp Asp Lys 
    130                 135                 140                 


His Leu Leu Lys Pro Trp Asp Ala Lys Lys Leu Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Arg Pro Arg Ser Cys Glu Val Pro Gly Ile Asn Ile Phe Pro Ser Pro 
                165                 170                 175     


Asp Gln Pro Ala Asn Val Pro Val Leu Pro Pro Ala Met Asn Xaa Gly 
            180                 185                 190         


Gly Ser Leu Pro Asp Leu Xaa Asn Leu His Phe Pro Pro Pro Leu Pro 
        195                 200                 205             


Xaa Pro Leu Asp Pro Glu Glu Xaa Ala Tyr Pro Ser Leu Ser Gly Gly 
    210                 215                 220                 


Asn Ser Xaa Ser Asn Leu Xaa His Xaa Met Xaa His Leu Gly Ile Ser 
225                 230                 235                 240 


Arg Gly Met Gly Leu Gly Pro Gly Tyr Asp Ala Pro Gly Leu His Ser 
                245                 250                 255     


Pro Leu Ser His Pro Ser Leu Gln Ser Ser Leu Ser Asn Pro Asn Leu 
            260                 265                 270         


Gln Ala Ser Leu Ser Ser Pro Gln Pro Gln Leu Gln Gly Ser His Ser 
        275                 280                 285             


His Pro Ser Leu Pro Ala Ser Ser Leu Ala Arg His Val Leu Pro Xaa 
    290                 295                 300                 


Xaa Ser Leu Gly His Pro Ser Leu Ser Ala Pro Ala Leu Ser Ser Ser 
305                 310                 315                 320 


Ser Ser Ser Ser Ser Xaa Ser Ser Pro Val Leu Gly Ala Pro Ser Tyr 
                325                 330                 335     


Pro Ala Ser Xaa Pro Gly Ala Ser Pro His His Arg Arg Val Pro Leu 
            340                 345                 350         


Ser Pro Leu Ser Leu Leu Ala Gly Pro Ala Asp Ala Arg Arg Ser Gln 
        355                 360                 365             


Gln Gln Leu Pro Lys Gln Phe Ser Pro Xaa Met Ser Pro Xaa Leu Ser 
    370                 375                 380                 


Ser Ile Xaa Gln Gly Val Pro Leu Asp Xaa Ser Lys Leu Ser Xaa Asp 
385                 390                 395                 400 


Gln Arg Leu Pro Pro Tyr Pro Tyr Ser Ser Pro Ser Leu Val Leu Pro 
                405                 410                 415     


Xaa Gln Pro His Xaa Pro Lys Ser Leu Gln Gln Pro Gly Leu Pro Ser 
            420                 425                 430         


Gln Ser Cys Ser Val Gln Ser Ser Gly Gly Gln Pro Pro Gly Arg Gln 
        435                 440                 445             


Ser His Tyr Gly Xaa Pro Tyr Pro Pro Gly Pro Ser Gly His Gly Gln 
    450                 455                 460                 


Gln Ser Tyr His Arg Pro Met Ser Asp Phe Asn Leu Gly Asn Leu Ala 
465                 470                 475                 480 


Leu 
    


<210> 6980
<211> 618
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<400> 6980
Met Ala Ala Ser Pro Gly Ser Gly Ser Ala Asn Pro Arg Lys Phe Ser 
1               5                   10                  15      


Glu Lys Ile Ala Leu His Xaa Gln Arg Gln Ala Glu Glu Xaa Arg Ala 
            20                  25                  30          


Phe Glu Gln Leu Met Xaa Asp Leu Xaa Leu Ser Arg Val Gln Phe Gln 
        35                  40                  45              


Lys Leu Gln Gln Leu Arg Leu Xaa Gln Tyr His Gly Gly Ser Leu Pro 
    50                  55                  60                  


Asn Val Ser Gln Leu Arg Ser Ser Ala Ser Glu Phe Gln Pro Ser Phe 
65                  70                  75                  80  


His Gln Ala Asp Asn Val Arg Gly Xaa Arg His His Gly Leu Val Glu 
                85                  90                  95      


Arg Pro Ser Arg Asn Arg Phe His Pro Leu His Arg Arg Ser Gly Asp 
            100                 105                 110         


Lys Pro Gly Arg Gln Phe Asp Gly Ser Ala Phe Gly Ala Asn Tyr Ser 
        115                 120                 125             


Ser Gln Pro Leu Asp Glu Ser Trp Pro Arg Gln Gln Pro Pro Trp Lys 
    130                 135                 140                 


Asp Glu Lys His Pro Gly Phe Arg Leu Xaa Ser Ala Leu Asn Arg Xaa 
145                 150                 155                 160 


Asn Ser Asp Ser Ala Leu His Xaa Ser Ala Leu Ser Xaa Lys Pro Gln 
                165                 170                 175     


Asp Pro Tyr Gly Gly Gly Gly Gln Ser Ala Trp Pro Ala Pro Tyr Met 
            180                 185                 190         


Gly Phe Cys Asp Gly Glu Asn Asn Gly His Gly Glu Val Ala Ser Phe 
        195                 200                 205             


Pro Gly Pro Leu Lys Glu Glu Asn Leu Leu Asn Val Pro Lys Pro Leu 
    210                 215                 220                 


Pro Lys Gln Leu Trp Glu Xaa Lys Glu Ile Gln Ser Leu Ser Gly Arg 
225                 230                 235                 240 


Pro Arg Ser Cys Asp Val Gly Gly Gly Asn Ala Phe Pro His Asn Gly 
                245                 250                 255     


Gln Asn Leu Gly Leu Ser Pro Phe Leu Gly Xaa Leu Asn Xaa Gly Gly 
            260                 265                 270         


Ser Leu Pro Asp Leu Xaa Asn Leu His Tyr Ser Xaa Pro Leu Pro Ala 
        275                 280                 285             


Ser Leu Asp Xaa Xaa Asp His His Phe Gly Ser Met Ser Val Gly Asn 
    290                 295                 300                 


Ser Val Asn Asn Ile Pro Ala Ala Met Xaa His Leu Gly Ile Arg Ser 
305                 310                 315                 320 


Ser Ser Gly Leu Gln Ser Ser Arg Ser Asn Pro Ser Ile Gln Ala Xaa 
                325                 330                 335     


Leu Asn Lys Xaa Val Leu Ser Ser Ser Leu Asn Asn His Pro Gln Xaa 
            340                 345                 350         


Ser Val Pro Asn Ala Ser Ala Leu His Pro Ser Leu Arg Leu Phe Ser 
        355                 360                 365             


Leu Ser Asn Pro Ser Leu Ser Xaa Xaa Asn Leu Ser Gly Pro Ser Arg 
    370                 375                 380                 


Arg Arg Gln Pro Pro Val Ser Pro Leu Xaa Leu Ser Pro Gly Pro Glu 
385                 390                 395                 400 


Ala His Gln Gly Phe Ser Arg Gln Leu Ser Ser Xaa Ser Pro Leu Ala 
                405                 410                 415     


Pro Tyr Pro Xaa Ser Gln Met Val Ser Ser Asp Arg Ser Gln Leu Ser 
            420                 425                 430         


Phe Leu Pro Xaa Glu Ala Gln Ala Gln Val Ser Pro Pro Pro Pro Tyr 
        435                 440                 445             


Pro Ala Pro Gln Glu Leu Xaa Gln Pro Leu Leu Gln Gln Pro Arg Ala 
    450                 455                 460                 


Pro Glu Ala Pro Ala Gln Gln Pro Gln Ala Ala Ser Ser Leu Pro Gln 
465                 470                 475                 480 


Ser Asp Phe Gln Leu Leu Pro Ala Gln Gly Ser Ser Leu Xaa Asn Phe 
                485                 490                 495     


Phe Pro Asp Val Gly Phe Asp Gln Gln Ser Met Arg Pro Gly Pro Ala 
            500                 505                 510         


Phe Pro Gln Gln Val Pro Leu Val Gln Gln Gly Ser Arg Glu Leu Gln 
        515                 520                 525             


Asp Ser Phe His Leu Arg Pro Ser Pro Tyr Ser Asn Cys Gly Ser Leu 
    530                 535                 540                 


Pro Asn Xaa Ile Leu Pro Asp Ser Ser Xaa Ser Leu Phe Lys Asp Leu 
545                 550                 555                 560 


Asn Ser Ala Leu Ala Gly Leu Pro Glu Val Ser Leu Asn Val Asp Xaa 
                565                 570                 575     


Pro Phe Pro Leu Glu Glu Glu Leu Gln Ile Glu Pro Leu Ser Leu Asp 
            580                 585                 590         


Gly Leu Asn Met Leu Ser Asp Ser Ser Met Gly Leu Leu Asp Pro Ser 
        595                 600                 605             


Val Glu Glu Xaa Phe Arg Ala Asp Arg Leu 
    610                 615             


<210> 6981
<211> 619
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<400> 6981
Met Ala Ala Ser Pro Gly Ser Gly Ser Ala Asn Pro Arg Lys Phe Ser 
1               5                   10                  15      


Glu Lys Ile Ala Leu His Xaa Gln Arg Gln Ala Glu Glu Xaa Arg Ala 
            20                  25                  30          


Phe Glu Gln Leu Met Xaa Asp Leu Xaa Leu Ser Arg Val Gln Phe Gln 
        35                  40                  45              


Lys Leu Gln Gln Leu Arg Leu Xaa Gln Tyr His Gly Gly Ser Leu Pro 
    50                  55                  60                  


Asn Val Ser Gln Leu Arg Ser Ser Ala Ser Glu Phe Gln Pro Ser Phe 
65                  70                  75                  80  


His Gln Ala Asp Asn Val Arg Gly Xaa Arg His His Gly Leu Val Glu 
                85                  90                  95      


Arg Pro Ser Arg Asn Arg Phe His Pro Leu His Arg Arg Ser Gly Asp 
            100                 105                 110         


Lys Pro Gly Arg Gln Phe Asp Gly Ser Ala Phe Gly Ala Asn Tyr Ser 
        115                 120                 125             


Ser Gln Pro Leu Asp Glu Ser Trp Pro Arg Gln Gln Pro Pro Trp Lys 
    130                 135                 140                 


Asp Glu Lys His Pro Gly Phe Arg Leu Xaa Ser Ala Leu Asn Arg Xaa 
145                 150                 155                 160 


Asn Ser Asp Ser Ala Leu His Xaa Ser Ala Leu Ser Xaa Lys Pro Gln 
                165                 170                 175     


Asp Pro Tyr Gly Gly Gly Gly Gln Ser Ala Trp Pro Ala Pro Tyr Met 
            180                 185                 190         


Gly Phe Cys Asp Gly Glu Asn Asn Gly His Gly Glu Val Ala Ser Phe 
        195                 200                 205             


Pro Gly Pro Leu Lys Glu Glu Asn Leu Leu Asn Val Pro Lys Pro Leu 
    210                 215                 220                 


Pro Lys Gln Leu Trp Glu Xaa Lys Glu Ile Gln Ser Leu Ser Gly Arg 
225                 230                 235                 240 


Pro Arg Ser Cys Asp Val Gly Gly Gly Asn Ala Phe Pro His Asn Gly 
                245                 250                 255     


Gln Asn Leu Gly Leu Ser Pro Phe Leu Gly Xaa Leu Asn Xaa Gly Gly 
            260                 265                 270         


Ser Leu Pro Asp Leu Xaa Asn Leu His Tyr Ser Xaa Pro Leu Pro Ala 
        275                 280                 285             


Ser Leu Asp Xaa Xaa Asp His His Phe Gly Ser Met Ser Val Gly Asn 
    290                 295                 300                 


Ser Val Asn Asn Ile Pro Ala Ala Met Xaa His Leu Gly Ile Arg Ser 
305                 310                 315                 320 


Ser Ser Gly Leu Gln Ser Ser Arg Ser Asn Pro Ser Ile Gln Ala Xaa 
                325                 330                 335     


Leu Asn Lys Xaa Val Leu Ser Ser Ser Leu Asn Asn His Pro Gln Xaa 
            340                 345                 350         


Ser Val Pro Asn Ala Ser Ala Leu His Pro Ser Leu Arg Leu Phe Ser 
        355                 360                 365             


Leu Ser Asn Pro Ser Leu Ser Xaa Xaa Asn Leu Ser Gly Pro Ser Arg 
    370                 375                 380                 


Arg Arg Gln Pro Pro Val Ser Pro Leu Xaa Leu Ser Pro Gly Pro Glu 
385                 390                 395                 400 


Ala His Gln Gly Phe Ser Arg Gln Leu Ser Ser Xaa Ser Pro Leu Ala 
                405                 410                 415     


Pro Tyr Pro Xaa Ser Gln Met Val Ser Ser Asp Arg Ser Gln Leu Ser 
            420                 425                 430         


Phe Leu Pro Xaa Glu Ala Gln Ala Gln Val Ser Pro Pro Pro Pro Tyr 
        435                 440                 445             


Pro Ala Pro Gln Glu Leu Xaa Gln Pro Leu Leu Gln Gln Pro Arg Ala 
    450                 455                 460                 


Pro Glu Ala Pro Ala Gln Gln Pro Gln Ala Ala Ser Ser Leu Pro Gln 
465                 470                 475                 480 


Ser Asp Phe Gln Leu Leu Pro Ala Gln Gly Ser Ser Leu Xaa Asn Phe 
                485                 490                 495     


Phe Pro Asp Val Gly Phe Asp Gln Gln Ser Met Arg Pro Gly Pro Ala 
            500                 505                 510         


Phe Pro Gln Gln Val Pro Leu Val Gln Gln Gly Ser Arg Glu Leu Gln 
        515                 520                 525             


Asp Ser Phe His Leu Arg Pro Ser Pro Tyr Ser Asn Cys Gly Ser Leu 
    530                 535                 540                 


Pro Asn Xaa Ile Leu Pro Glu Asp Ser Ser Xaa Ser Leu Phe Lys Asp 
545                 550                 555                 560 


Leu Asn Ser Ala Leu Ala Gly Leu Pro Glu Val Ser Leu Asn Val Asp 
                565                 570                 575     


Xaa Pro Phe Pro Leu Glu Glu Glu Leu Gln Ile Glu Pro Leu Ser Leu 
            580                 585                 590         


Asp Gly Leu Asn Met Leu Ser Asp Ser Ser Met Gly Leu Leu Asp Pro 
        595                 600                 605             


Ser Val Glu Glu Xaa Phe Arg Ala Asp Arg Leu 
    610                 615                 


<210> 6982
<211> 91
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<400> 6982
Met Ala Ala Ser Pro Gly Ser Gly Ser Ala Asn Pro Arg Lys Phe Ser 
1               5                   10                  15      


Glu Lys Ile Ala Leu His Xaa Gln Arg Gln Ala Glu Glu Xaa Arg Ala 
            20                  25                  30          


Phe Glu Gln Leu Met Xaa Asp Leu Xaa Leu Ser Arg Val Gln Phe Gln 
        35                  40                  45              


Lys Leu Gln Gln Leu Arg Leu Xaa Gln Tyr His Gly Gly Ser Leu Pro 
    50                  55                  60                  


Asn Val Ser Gln Leu Arg Ser Ser Ala Ser Glu Phe Gln Val Glu Arg 
65                  70                  75                  80  


Asn Ser Ser Pro Cys Val Asp Gly Leu Arg Gln 
                85                  90      


<210> 6983
<211> 190
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(179)
<223> Selenocysteine

<400> 6983
Xaa His Pro Leu His Arg Arg Ser Gly Asp Lys Pro Gly Arg Gln Phe 
1               5                   10                  15      


Asp Gly Ser Ala Phe Gly Ala Asn Tyr Ser Ser Gln Pro Leu Asp Glu 
            20                  25                  30          


Ser Trp Pro Arg Gln Gln Pro Pro Trp Lys Asp Glu Lys His Pro Gly 
        35                  40                  45              


Phe Arg Leu Xaa Ser Ala Leu Asn Arg Xaa Asn Ser Asp Ser Ala Leu 
    50                  55                  60                  


His Xaa Ser Ala Leu Ser Xaa Lys Pro Gln Asp Pro Tyr Gly Gly Gly 
65                  70                  75                  80  


Gly Gln Ser Ala Trp Pro Ala Pro Tyr Met Val Ala Ser Phe Pro Gly 
                85                  90                  95      


Pro Leu Lys Glu Glu Asn Leu Leu Asn Val Pro Lys Pro Leu Pro Lys 
            100                 105                 110         


Gln Leu Trp Glu Xaa Lys Glu Ile Gln Ser Leu Ser Gly Arg Pro Arg 
        115                 120                 125             


Ser Cys Asp Val Gly Gly Gly Asn Ala Phe Pro His Asn Gly Gln Asn 
    130                 135                 140                 


Leu Gly Leu Ser Pro Phe Leu Gly Xaa Leu Asn Xaa Gly Gly Ser Leu 
145                 150                 155                 160 


Pro Asp Leu Xaa Asn Leu His Tyr Ser Xaa Pro Leu Pro Ala Ser Leu 
                165                 170                 175     


Asp Xaa Xaa Asp His His Phe Gly Ser Met Ser Val Gly Asn 
            180                 185                 190 


<210> 6984
<211> 57
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<400> 6984
Met Met Ala Tyr Met Asn Pro Gly Pro His Tyr Ser Val Asn Ala Leu 
1               5                   10                  15      


Ala Leu Ser Gly Pro Ser Val Asp Leu Met His Gln Ala Val Pro Tyr 
            20                  25                  30          


Pro Ser Ala Pro Arg Lys Gln Arg Arg Glu Arg Xaa Xaa Phe Xaa Arg 
        35                  40                  45              


Ser Gln Leu Glu Glu Leu Glu Ala Leu 
    50                  55          


<210> 6985
<211> 299
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<400> 6985
Met Met Ala Tyr Met Asn Pro Gly Pro His Tyr Ser Val Asn Ala Leu 
1               5                   10                  15      


Ala Leu Ser Gly Pro Ser Val Asp Leu Met His Gln Ala Val Pro Tyr 
            20                  25                  30          


Pro Ser Ala Pro Arg Lys Gln Arg Arg Glu Arg Xaa Xaa Phe Xaa Arg 
        35                  40                  45              


Ser Gln Leu Glu Glu Leu Glu Ala Leu Phe Ala Lys Xaa Gln Tyr Pro 
    50                  55                  60                  


Asp Val Tyr Ala Arg Glu Glu Val Ala Leu Lys Ile Asn Leu Pro Glu 
65                  70                  75                  80  


Ser Arg Val Gln Val Trp Phe Lys Asn Arg Arg Ala Lys Cys Arg Gln 
                85                  90                  95      


Gln Arg Gln Gln Gln Lys Gln Gln Gln Gln Pro Pro Gly Gly Gln Ala 
            100                 105                 110         


Lys Ala Arg Pro Ala Lys Arg Lys Ala Gly Xaa Ser Pro Arg Pro Ser 
        115                 120                 125             


Xaa Asp Val Cys Pro Asp Pro Leu Gly Ile Ser Asp Ser Tyr Ser Pro 
    130                 135                 140                 


Pro Leu Pro Gly Pro Ser Gly Ser Pro Xaa Xaa Ala Val Ala Xaa Val 
145                 150                 155                 160 


Ser Ile Trp Ser Pro Ala Ser Glu Ser Pro Leu Pro Glu Ala Gln Arg 
                165                 170                 175     


Ala Gly Leu Val Ala Ser Gly Pro Ser Leu Xaa Ser Ala Pro Tyr Ala 
            180                 185                 190         


Met Xaa Tyr Ala Pro Ala Ser Ala Phe Cys Ser Ser Pro Ser Ala Tyr 
        195                 200                 205             


Gly Ser Pro Ser Ser Tyr Phe Ser Gly Leu Asp Pro Tyr Leu Ser Pro 
    210                 215                 220                 


Met Val Pro Gln Leu Gly Gly Pro Ala Leu Ser Pro Leu Ser Gly Pro 
225                 230                 235                 240 


Ser Val Gly Pro Ser Leu Ala Gln Ser Pro Xaa Ser Leu Ser Gly Gln 
                245                 250                 255     


Ser Tyr Gly Ala Tyr Ser Pro Val Asp Ser Leu Glu Phe Lys Asp Pro 
            260                 265                 270         


Xaa Gly Xaa Trp Lys Phe Xaa Tyr Asn Pro Met Asp Pro Leu Asp Tyr 
        275                 280                 285             


Lys Asp Gln Ser Ala Trp Lys Phe Gln Ile Leu 
    290                 295                 


<210> 6986
<211> 41
<212> PRT
<213> Homo sapiens

<400> 6986
Met Met Ala Tyr Met Asn Pro Gly Pro His Tyr Ser Val Asn Ala Leu 
1               5                   10                  15      


Ala Leu Ser Gly Pro Ser Val Asp Leu Met His Gln Ala Val Pro Tyr 
            20                  25                  30          


Pro Ser Leu Val Gln Glu Pro Glu Gly 
        35                  40      


<210> 6987
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<400> 6987
Ile Glu Arg Met Lys Gln Ile Tyr Gln Gln Leu Ser Arg Tyr Arg Gly 
1               5                   10                  15      


Leu Gly Leu Leu Ala Ser Val Pro Ser Asn Pro Asn Gly Asn Gly Gly 
            20                  25                  30          


Phe Met Gly Tyr Ser Ala Glu Asn Ile Pro Gly Cys Ser Ser Ser Gly 
        35                  40                  45              


Ser Cys Ser Gln Gly Ser Gly Ile Leu His Tyr Ala His Gly Asp Ser 
    50                  55                  60                  


Gln Gln Xaa His Leu Leu Lys Gln Gly Arg Ser Ser Met Gly Xaa Gly 
65                  70                  75                  80  


Leu Ser Gly Gly Lys Arg Pro Ser Gln Glu Glu Asp Xaa Gln Ser Ile 
                85                  90                  95      


Gly Pro Lys Val Gln Arg Gln Ser Xaa Asn 
            100                 105     


<210> 6988
<211> 586
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<400> 6988
Met Gly Val Asn Ala Val His Trp Phe Arg Lys Gly Leu Arg Leu His 
1               5                   10                  15      


Asp Asn Pro Ala Leu Lys Glu Cys Ile Gln Gly Ala Asp Xaa Ile Arg 
            20                  25                  30          


Cys Val Tyr Ile Leu Asp Pro Trp Phe Ala Gly Ser Ser Asn Val Gly 
        35                  40                  45              


Ile Asn Arg Trp Arg Phe Leu Leu Gln Cys Leu Glu Asp Leu Asp Ala 
    50                  55                  60                  


Asn Leu Arg Lys Leu Asn Ser Arg Leu Phe Val Ile Arg Gly Gln Pro 
65                  70                  75                  80  


Ala Asp Val Phe Pro Arg Leu Phe Lys Glu Trp Asn Ile Xaa Lys Leu 
                85                  90                  95      


Ser Ile Glu Tyr Asp Ser Glu Pro Phe Gly Lys Glu Arg Asp Ala Ala 
            100                 105                 110         


Ile Lys Lys Leu Ala Xaa Glu Ala Gly Val Glu Val Ile Val Arg Ile 
        115                 120                 125             


Ser His Xaa Leu Tyr Asp Leu Asp Lys Ile Ile Glu Leu Asn Gly Gly 
    130                 135                 140                 


Gln Pro Pro Leu Xaa Tyr Lys Arg Phe Gln Xaa Leu Ile Ser Lys Met 
145                 150                 155                 160 


Glu Pro Leu Glu Ile Pro Val Glu Xaa Ile Xaa Ser Glu Val Ile Glu 
                165                 170                 175     


Lys Cys Xaa Xaa Pro Leu Ser Asp Asp His Asp Glu Lys Tyr Gly Val 
            180                 185                 190         


Pro Ser Leu Glu Glu Leu Gly Phe Asp Xaa Asp Gly Leu Ser Ser Ala 
        195                 200                 205             


Val Trp Pro Gly Gly Glu Xaa Glu Ala Leu Xaa Arg Leu Glu Arg His 
    210                 215                 220                 


Leu Glu Arg Lys Ala Trp Val Ala Asn Phe Glu Arg Pro Arg Met Asn 
225                 230                 235                 240 


Ala Asn Ser Leu Leu Ala Ser Pro Xaa Gly Leu Ser Pro Tyr Leu Arg 
                245                 250                 255     


Phe Gly Cys Leu Ser Cys Arg Leu Phe Tyr Phe Lys Leu Xaa Asp Leu 
            260                 265                 270         


Tyr Lys Lys Val Lys Lys Asn Ser Ser Pro Pro Leu Ser Leu Tyr Gly 
        275                 280                 285             


Gln Leu Leu Trp Arg Glu Phe Phe Tyr Xaa Ala Ala Xaa Asn Asn Pro 
    290                 295                 300                 


Arg Phe Asp Lys Met Glu Gly Asn Pro Ile Cys Val Gln Ile Pro Trp 
305                 310                 315                 320 


Asp Lys Asn Pro Glu Ala Leu Ala Lys Trp Ala Glu Gly Arg Xaa Gly 
                325                 330                 335     


Phe Pro Trp Ile Asp Ala Ile Met Xaa Gln Leu Arg Gln Glu Gly Trp 
            340                 345                 350         


Ile His His Leu Ala Arg His Ala Val Ala Cys Phe Leu Xaa Arg Gly 
        355                 360                 365             


Asp Leu Trp Ile Ser Trp Glu Glu Gly Met Lys Val Phe Glu Glu Leu 
    370                 375                 380                 


Leu Leu Asp Ala Asp Trp Ser Ile Asn Ala Gly Ser Trp Met Trp Leu 
385                 390                 395                 400 


Ser Cys Ser Ser Phe Phe Gln Gln Phe Phe His Cys Tyr Cys Pro Val 
                405                 410                 415     


Gly Phe Gly Arg Arg Xaa Asp Pro Asn Gly Asp Tyr Ile Arg Arg Tyr 
            420                 425                 430         


Leu Pro Val Leu Arg Gly Phe Pro Ala Lys Tyr Ile Tyr Asp Pro Trp 
        435                 440                 445             


Asn Ala Pro Glu Gly Ile Gln Lys Val Ala Lys Cys Leu Ile Gly Val 
    450                 455                 460                 


Asn Tyr Pro Lys Pro Met Val Asn His Ala Glu Ala Ser Arg Leu Asn 
465                 470                 475                 480 


Ile Glu Arg Met Lys Gln Ile Tyr Gln Gln Leu Ser Arg Tyr Arg Gly 
                485                 490                 495     


Leu Gly Leu Leu Ala Ser Val Pro Ser Asn Pro Asn Gly Asn Gly Gly 
            500                 505                 510         


Phe Met Gly Tyr Ser Ala Glu Asn Ile Pro Gly Cys Ser Ser Ser Gly 
        515                 520                 525             


Ser Cys Ser Gln Gly Ser Gly Ile Leu His Tyr Ala His Gly Asp Ser 
    530                 535                 540                 


Gln Gln Xaa His Leu Leu Lys Gln Gly Arg Ser Ser Met Gly Xaa Gly 
545                 550                 555                 560 


Leu Ser Gly Gly Lys Arg Pro Ser Gln Glu Glu Asp Xaa Gln Ser Ile 
                565                 570                 575     


Gly Pro Lys Val Gln Arg Gln Ser Xaa Asn 
            580                 585     


<210> 6989
<211> 593
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<400> 6989
Met Ala Ala Xaa Val Ala Xaa Ala Ala Ala Val Ala Pro Ala Pro Ala 
1               5                   10                  15      


Pro Gly Xaa Asp Ser Ala Ser Ser Val His Trp Phe Arg Lys Gly Leu 
            20                  25                  30          


Arg Leu His Asp Asn Pro Ala Leu Leu Ala Ala Val Arg Gly Ala Arg 
        35                  40                  45              


Cys Val Arg Cys Val Tyr Ile Leu Asp Pro Trp Phe Ala Ala Ser Ser 
    50                  55                  60                  


Ser Val Gly Ile Asn Arg Trp Arg Phe Leu Leu Gln Ser Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Xaa Ser Leu Arg Lys Leu Asn Ser Arg Leu Phe Val Val Arg 
                85                  90                  95      


Gly Gln Pro Ala Asp Val Phe Pro Arg Leu Phe Lys Glu Trp Gly Val 
            100                 105                 110         


Xaa Arg Leu Xaa Phe Glu Tyr Asp Ser Glu Pro Phe Gly Lys Glu Arg 
        115                 120                 125             


Asp Ala Ala Ile Met Lys Met Ala Lys Glu Ala Gly Val Glu Val Val 
    130                 135                 140                 


Xaa Glu Asn Ser His Xaa Leu Tyr Asp Leu Asp Arg Ile Ile Glu Leu 
145                 150                 155                 160 


Asn Gly Gln Lys Pro Pro Leu Xaa Tyr Lys Arg Phe Gln Ala Ile Ile 
                165                 170                 175     


Ser Arg Met Glu Leu Pro Lys Lys Pro Val Gly Leu Val Xaa Ser Gln 
            180                 185                 190         


Gln Met Glu Ser Cys Arg Ala Glu Ile Gln Glu Asn His Asp Glu Xaa 
        195                 200                 205             


Tyr Gly Val Pro Ser Leu Glu Glu Leu Gly Phe Pro Xaa Glu Gly Leu 
    210                 215                 220                 


Gly Pro Ala Val Trp Gln Gly Gly Glu Xaa Glu Ala Leu Ala Arg Leu 
225                 230                 235                 240 


Asp Lys His Leu Glu Arg Lys Ala Trp Val Ala Asn Tyr Glu Arg Pro 
                245                 250                 255     


Arg Met Asn Ala Asn Ser Leu Leu Ala Ser Pro Xaa Gly Leu Ser Pro 
            260                 265                 270         


Tyr Leu Arg Phe Gly Cys Leu Ser Cys Arg Leu Phe Tyr Tyr Arg Leu 
        275                 280                 285             


Trp Asp Leu Tyr Lys Lys Val Lys Arg Asn Ser Xaa Pro Pro Leu Ser 
    290                 295                 300                 


Leu Phe Gly Gln Leu Leu Trp Arg Glu Phe Phe Tyr Xaa Ala Ala Xaa 
305                 310                 315                 320 


Asn Asn Pro Arg Phe Asp Arg Met Glu Gly Asn Pro Ile Cys Ile Gln 
                325                 330                 335     


Ile Pro Trp Asp Arg Asn Pro Glu Ala Leu Ala Lys Trp Ala Glu Gly 
            340                 345                 350         


Lys Xaa Gly Phe Pro Trp Ile Asp Ala Ile Met Xaa Gln Leu Arg Gln 
        355                 360                 365             


Glu Gly Trp Ile His His Leu Ala Arg His Ala Val Ala Cys Phe Leu 
    370                 375                 380                 


Xaa Arg Gly Asp Leu Trp Val Ser Trp Glu Ser Gly Val Arg Val Phe 
385                 390                 395                 400 


Asp Glu Leu Leu Leu Asp Ala Asp Phe Ser Val Asn Ala Gly Ser Trp 
                405                 410                 415     


Met Trp Leu Ser Cys Ser Ala Phe Phe Gln Gln Phe Phe His Cys Tyr 
            420                 425                 430         


Cys Pro Val Gly Phe Gly Arg Arg Xaa Asp Pro Ser Gly Asp Tyr Ile 
        435                 440                 445             


Arg Arg Tyr Leu Pro Lys Leu Lys Ala Phe Pro Ser Arg Tyr Ile Tyr 
    450                 455                 460                 


Glu Pro Trp Asn Ala Pro Glu Ser Ile Gln Lys Ala Ala Lys Cys Ile 
465                 470                 475                 480 


Ile Gly Val Asp Tyr Pro Arg Pro Ile Val Asn His Ala Glu Xaa Ser 
                485                 490                 495     


Arg Leu Asn Ile Glu Arg Met Lys Gln Ile Tyr Gln Gln Leu Ser Arg 
            500                 505                 510         


Tyr Arg Gly Leu Cys Leu Leu Ala Ser Val Pro Ser Cys Val Glu Asp 
        515                 520                 525             


Leu Ser His Pro Val Ala Glu Pro Ser Ser Ser Gln Ala Gly Ser Met 
    530                 535                 540                 


Ser Ser Ala Gly Pro Arg Pro Leu Pro Ser Gly Pro Ala Ser Pro Lys 
545                 550                 555                 560 


Arg Lys Leu Glu Ala Ala Glu Glu Pro Pro Gly Glu Glu Leu Ser Lys 
                565                 570                 575     


Arg Ala Arg Val Ala Glu Leu Pro Xaa Pro Glu Leu Pro Ser Lys Asp 
            580                 585                 590         


Ala 
    


<210> 6990
<211> 614
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<400> 6990
Met Gly Gly Val His Val Ala Tyr Arg Gly Gly Ala Gly Val Ala Gly 
1               5                   10                  15      


Ala Val Trp Xaa Val Met Ala Ala Xaa Val Ala Xaa Ala Ala Ala Val 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Gly Xaa Asp Ser Ala Ser Ser Val His Trp 
        35                  40                  45              


Phe Arg Lys Gly Leu Arg Leu His Asp Asn Pro Ala Leu Leu Ala Ala 
    50                  55                  60                  


Val Arg Gly Ala Arg Cys Val Arg Cys Val Tyr Ile Leu Asp Pro Trp 
65                  70                  75                  80  


Phe Ala Ala Ser Ser Ser Val Gly Ile Asn Arg Trp Arg Phe Leu Leu 
                85                  90                  95      


Gln Ser Leu Glu Asp Leu Asp Xaa Ser Leu Arg Lys Leu Asn Ser Arg 
            100                 105                 110         


Leu Phe Val Val Arg Gly Gln Pro Ala Asp Val Phe Pro Arg Leu Phe 
        115                 120                 125             


Lys Glu Trp Gly Val Xaa Arg Leu Xaa Phe Glu Tyr Asp Ser Glu Pro 
    130                 135                 140                 


Phe Gly Lys Glu Arg Asp Ala Ala Ile Met Lys Met Ala Lys Glu Ala 
145                 150                 155                 160 


Gly Val Glu Val Val Xaa Glu Asn Ser His Xaa Leu Tyr Asp Leu Asp 
                165                 170                 175     


Arg Ile Ile Glu Leu Asn Gly Gln Lys Pro Pro Leu Xaa Tyr Lys Arg 
            180                 185                 190         


Phe Gln Ala Ile Ile Ser Arg Met Glu Leu Pro Lys Lys Pro Val Gly 
        195                 200                 205             


Leu Val Xaa Ser Gln Gln Met Glu Ser Cys Arg Ala Glu Ile Gln Glu 
    210                 215                 220                 


Asn His Asp Glu Xaa Tyr Gly Val Pro Ser Leu Glu Glu Leu Gly Phe 
225                 230                 235                 240 


Pro Xaa Glu Gly Leu Gly Pro Ala Val Trp Gln Gly Gly Glu Xaa Glu 
                245                 250                 255     


Ala Leu Ala Arg Leu Asp Lys His Leu Glu Arg Lys Ala Trp Val Ala 
            260                 265                 270         


Asn Tyr Glu Arg Pro Arg Met Asn Ala Asn Ser Leu Leu Ala Ser Pro 
        275                 280                 285             


Xaa Gly Leu Ser Pro Tyr Leu Arg Phe Gly Cys Leu Ser Cys Arg Leu 
    290                 295                 300                 


Phe Tyr Tyr Arg Leu Trp Asp Leu Tyr Lys Lys Val Lys Arg Asn Ser 
305                 310                 315                 320 


Xaa Pro Pro Leu Ser Leu Phe Gly Gln Leu Leu Trp Arg Glu Phe Phe 
                325                 330                 335     


Tyr Xaa Ala Ala Xaa Asn Asn Pro Arg Phe Asp Arg Met Glu Gly Asn 
            340                 345                 350         


Pro Ile Cys Ile Gln Ile Pro Trp Asp Arg Asn Pro Glu Ala Leu Ala 
        355                 360                 365             


Lys Trp Ala Glu Gly Lys Xaa Gly Phe Pro Trp Ile Asp Ala Ile Met 
    370                 375                 380                 


Xaa Gln Leu Arg Gln Glu Gly Trp Ile His His Leu Ala Arg His Ala 
385                 390                 395                 400 


Val Ala Cys Phe Leu Xaa Arg Gly Asp Leu Trp Val Ser Trp Glu Ser 
                405                 410                 415     


Gly Val Arg Val Phe Asp Glu Leu Leu Leu Asp Ala Asp Phe Ser Val 
            420                 425                 430         


Asn Ala Gly Ser Trp Met Trp Leu Ser Cys Ser Ala Phe Phe Gln Gln 
        435                 440                 445             


Phe Phe His Cys Tyr Cys Pro Val Gly Phe Gly Arg Arg Xaa Asp Pro 
    450                 455                 460                 


Ser Gly Asp Tyr Ile Arg Arg Tyr Leu Pro Lys Leu Lys Ala Phe Pro 
465                 470                 475                 480 


Ser Arg Tyr Ile Tyr Glu Pro Trp Asn Ala Pro Glu Ser Ile Gln Lys 
                485                 490                 495     


Ala Ala Lys Cys Ile Ile Gly Val Asp Tyr Pro Arg Pro Ile Val Asn 
            500                 505                 510         


His Ala Glu Xaa Ser Arg Leu Asn Ile Glu Arg Met Lys Gln Ile Tyr 
        515                 520                 525             


Gln Gln Leu Ser Arg Tyr Arg Gly Leu Cys Leu Leu Ala Ser Val Pro 
    530                 535                 540                 


Ser Cys Val Glu Asp Leu Ser His Pro Val Ala Glu Pro Ser Ser Ser 
545                 550                 555                 560 


Gln Ala Gly Ser Met Ser Ser Ala Gly Pro Arg Pro Leu Pro Ser Gly 
                565                 570                 575     


Pro Ala Ser Pro Lys Arg Lys Leu Glu Ala Ala Glu Glu Pro Pro Gly 
            580                 585                 590         


Glu Glu Leu Ser Lys Arg Ala Arg Val Ala Glu Leu Pro Xaa Pro Glu 
        595                 600                 605             


Leu Pro Ser Lys Asp Ala 
    610                 


<210> 6991
<211> 532
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<400> 6991
Met Pro Ala Pro Pro Gly Arg Xaa His Xaa Trp Phe Leu Leu Gln Ser 
1               5                   10                  15      


Leu Glu Asp Leu Asp Xaa Ser Leu Arg Lys Leu Asn Ser Arg Leu Phe 
            20                  25                  30          


Val Val Arg Gly Gln Pro Ala Asp Val Phe Pro Arg Leu Phe Lys Glu 
        35                  40                  45              


Trp Gly Val Xaa Arg Leu Xaa Phe Glu Tyr Asp Ser Glu Pro Phe Gly 
    50                  55                  60                  


Lys Glu Arg Asp Ala Ala Ile Met Lys Met Ala Lys Glu Ala Gly Val 
65                  70                  75                  80  


Glu Val Val Xaa Glu Asn Ser His Xaa Leu Tyr Asp Leu Asp Arg Ile 
                85                  90                  95      


Ile Glu Leu Asn Gly Gln Lys Pro Pro Leu Xaa Tyr Lys Arg Phe Gln 
            100                 105                 110         


Ala Ile Ile Ser Arg Met Glu Leu Pro Lys Lys Pro Val Gly Leu Val 
        115                 120                 125             


Xaa Ser Gln Gln Met Glu Ser Cys Arg Ala Glu Ile Gln Glu Asn His 
    130                 135                 140                 


Asp Glu Xaa Tyr Gly Val Pro Ser Leu Glu Glu Leu Gly Phe Pro Xaa 
145                 150                 155                 160 


Glu Gly Leu Gly Pro Ala Val Trp Gln Gly Gly Glu Xaa Glu Ala Leu 
                165                 170                 175     


Ala Arg Leu Asp Lys His Leu Glu Arg Lys Ala Trp Val Ala Asn Tyr 
            180                 185                 190         


Glu Arg Pro Arg Met Asn Ala Asn Ser Leu Leu Ala Ser Pro Xaa Gly 
        195                 200                 205             


Leu Ser Pro Tyr Leu Arg Phe Gly Cys Leu Ser Cys Arg Leu Phe Tyr 
    210                 215                 220                 


Tyr Arg Leu Trp Asp Leu Tyr Lys Lys Val Lys Arg Asn Ser Xaa Pro 
225                 230                 235                 240 


Pro Leu Ser Leu Phe Gly Gln Leu Leu Trp Arg Glu Phe Phe Tyr Xaa 
                245                 250                 255     


Ala Ala Xaa Asn Asn Pro Arg Phe Asp Arg Met Glu Gly Asn Pro Ile 
            260                 265                 270         


Cys Ile Gln Ile Pro Trp Asp Arg Asn Pro Glu Ala Leu Ala Lys Trp 
        275                 280                 285             


Ala Glu Gly Lys Xaa Gly Phe Pro Trp Ile Asp Ala Ile Met Xaa Gln 
    290                 295                 300                 


Leu Arg Gln Glu Gly Trp Ile His His Leu Ala Arg His Ala Val Ala 
305                 310                 315                 320 


Cys Phe Leu Xaa Arg Gly Asp Leu Trp Val Ser Trp Glu Ser Gly Val 
                325                 330                 335     


Arg Val Phe Asp Glu Leu Leu Leu Asp Ala Asp Phe Ser Val Asn Ala 
            340                 345                 350         


Gly Ser Trp Met Trp Leu Ser Cys Ser Ala Phe Phe Gln Gln Phe Phe 
        355                 360                 365             


His Cys Tyr Cys Pro Val Gly Phe Gly Arg Arg Xaa Asp Pro Ser Gly 
    370                 375                 380                 


Asp Tyr Ile Arg Arg Tyr Leu Pro Lys Leu Lys Ala Phe Pro Ser Arg 
385                 390                 395                 400 


Tyr Ile Tyr Glu Pro Trp Asn Ala Pro Glu Ser Ile Gln Lys Ala Ala 
                405                 410                 415     


Lys Cys Ile Ile Gly Val Asp Tyr Pro Arg Pro Ile Val Asn His Ala 
            420                 425                 430         


Glu Xaa Ser Arg Leu Asn Ile Glu Arg Met Lys Gln Ile Tyr Gln Gln 
        435                 440                 445             


Leu Ser Arg Tyr Arg Gly Leu Cys Leu Leu Ala Ser Val Pro Ser Cys 
    450                 455                 460                 


Val Glu Asp Leu Ser His Pro Val Ala Glu Pro Ser Ser Ser Gln Ala 
465                 470                 475                 480 


Gly Ser Met Ser Ser Ala Gly Pro Arg Pro Leu Pro Ser Gly Pro Ala 
                485                 490                 495     


Ser Pro Lys Arg Lys Leu Glu Ala Ala Glu Glu Pro Pro Gly Glu Glu 
            500                 505                 510         


Leu Ser Lys Arg Ala Arg Val Ala Glu Leu Pro Xaa Pro Glu Leu Pro 
        515                 520                 525             


Ser Lys Asp Ala 
    530         


<210> 6992
<211> 215
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<400> 6992
Met Glu Xaa Gln Ala Glu Gln Gln Glu Leu Glu Xaa Leu Pro Xaa Xaa 
1               5                   10                  15      


Lys Met Ala Gln Xaa Asn Pro Xaa Pro Gly Ser Leu Gly Pro Trp Lys 
            20                  25                  30          


Ile Xaa Ile Tyr Asp Gln Glu Asn Phe Gln Gly Lys Arg Met Glu Phe 
        35                  40                  45              


Xaa Ser Ser Cys Pro Asn Val Ser Glu Arg Ser Phe Asp Asn Val Arg 
    50                  55                  60                  


Ser Leu Lys Val Glu Ser Gly Ala Trp Ile Gly Tyr Glu His Xaa Ser 
65                  70                  75                  80  


Phe Cys Gly Gln Gln Phe Ile Leu Glu Arg Gly Glu Tyr Pro Arg Trp 
                85                  90                  95      


Asp Ala Trp Ser Gly Ser Asn Ala Tyr His Ile Glu Arg Leu Met Ser 
            100                 105                 110         


Phe Arg Pro Ile Cys Ser Ala Asn His Lys Glu Ser Lys Met Xaa Ile 
        115                 120                 125             


Phe Glu Lys Glu Asn Phe Ile Gly Arg Gln Trp Glu Ile Ser Asp Asp 
    130                 135                 140                 


Tyr Pro Ser Leu Gln Ala Met Gly Trp Phe Asn Asn Glu Val Gly Ser 
145                 150                 155                 160 


Met Lys Ile Gln Ser Gly Ala Trp Val Cys Tyr Gln Tyr Pro Gly Tyr 
                165                 170                 175     


Arg Gly Tyr Gln Tyr Ile Leu Glu Cys Asp His His Gly Gly Asp Tyr 
            180                 185                 190         


Lys His Trp Arg Glu Trp Gly Ser His Ala Gln Xaa Ser Gln Ile Gln 
        195                 200                 205             


Ser Ile Arg Arg Ile Gln Gln 
    210                 215 


<210> 6993
<211> 75
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<400> 6993
Xaa Ala Glu Gln Gln Glu Leu Glu Xaa Leu Pro Xaa Xaa Lys Met Ala 
1               5                   10                  15      


Gln Xaa Asn Pro Xaa Pro Gly Ser Leu Gly Pro Trp Lys Ile Xaa Ile 
            20                  25                  30          


Tyr Asp Gln Glu Asn Phe Gln Gly Lys Arg Met Glu Phe Xaa Ser Ser 
        35                  40                  45              


Cys Pro Asn Val Ser Glu Arg Ser Phe Asp Asn Val Arg Ser Leu Lys 
    50                  55                  60                  


Val Glu Ser Gly Ala Ile Ile Arg Ser Leu Arg 
65                  70                  75  


<210> 6994
<211> 151
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<400> 6994
Lys Ser Pro Val Trp Pro Xaa Phe Pro Phe His Arg Glu Gly Ser Arg 
1               5                   10                  15      


Val Trp Glu Arg Gly Gly Val Pro Pro Arg Asp Leu Pro Ser Pro Leu 
            20                  25                  30          


Pro Xaa Lys Arg Xaa Arg Xaa Tyr Ser Ala Xaa Ala Arg Ala Ser Ala 
        35                  40                  45              


Gly Pro Val Phe Lys Gly Val Cys Lys Gln Phe Ser Arg Ser Gln Gly 
    50                  55                  60                  


His Gly Phe Ile Xaa Pro Glu Asn Gly Ser Glu Asp Ile Phe Val His 
65                  70                  75                  80  


Val Ser Glu Pro Arg Pro Asn Ser Ser Glu Val Xaa Xaa His Arg Cys 
                85                  90                  95      


Gly Pro Arg Ser Arg Leu Met Ser Cys Leu Trp Glu Glu Asn Leu Pro 
            100                 105                 110         


Ala Ser Leu His Arg Val Leu Arg Arg His His Ala Val Ala Asn Ser 
        115                 120                 125             


Pro Gly Val Gly Lys Asp Leu Lys Val Val Pro Xaa Leu His Xaa Glu 
    130                 135                 140                 


Asp Gly Gln Arg Arg Asp Ile 
145                 150     


<210> 6995
<211> 153
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<400> 6995
Met Xaa Ser Glu Ser Xaa Ser Pro Pro Val Val Pro Pro Leu His Ser 
1               5                   10                  15      


Pro Lys Ser Pro Val Trp Pro Xaa Phe Pro Phe His Arg Glu Gly Ser 
            20                  25                  30          


Arg Val Trp Glu Arg Gly Gly Val Pro Pro Arg Asp Leu Pro Ser Pro 
        35                  40                  45              


Leu Pro Xaa Lys Arg Xaa Arg Xaa Tyr Ser Ala Xaa Ala Arg Ala Ser 
    50                  55                  60                  


Ala Gly Pro Val Phe Lys Gly Val Cys Lys Gln Phe Ser Arg Ser Gln 
65                  70                  75                  80  


Gly His Gly Phe Ile Xaa Pro Glu Asn Gly Ser Glu Asp Ile Phe Val 
                85                  90                  95      


His Val Ser Asp Ile Glu Gly Glu Tyr Val Pro Val Glu Gly Asp Glu 
            100                 105                 110         


Val Xaa Tyr Lys Met Cys Pro Ile Pro Pro Lys Asn Gln Lys Phe Gln 
        115                 120                 125             


Ala Val Glu Val Val Leu Xaa Gln Leu Ala Pro His Xaa Pro His Glu 
    130                 135                 140                 


Xaa Trp Ser Gly Gln Val Val Gly Ser 
145                 150             


<210> 6996
<211> 813
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (776)..(776)
<223> Selenocysteine

<400> 6996
Met Glu Asn Val Phe Xaa Val Ser Ser Asp Pro His Pro Ser Pro Ala 
1               5                   10                  15      


Ala Pro Pro Ser Leu Ser Leu Pro Leu Ser Ser Ser Ser Xaa Ser Ser 
            20                  25                  30          


Gly Xaa Lys Lys Gln Lys Arg Xaa Pro Xaa Tyr Gln Arg Ser Met Ser 
        35                  40                  45              


Phe Asp Pro Asn Leu Leu His Asn Asn Gly His Asn Gly Tyr Pro Asn 
    50                  55                  60                  


Gly Xaa Ser Ala Ala Leu Arg Glu Xaa Gly Val Ile Glu Lys Leu Leu 
65                  70                  75                  80  


Xaa Ser Tyr Gly Phe Ile Gln Cys Ser Glu Arg Gln Ala Arg Leu Phe 
                85                  90                  95      


Phe His Cys Ser Gln Tyr Asn Gly Asn Leu Gln Asp Leu Lys Val Gly 
            100                 105                 110         


Asp Asp Val Glu Phe Glu Val Ser Ser Asp Arg Arg Xaa Gly Lys Pro 
        115                 120                 125             


Ile Ala Val Lys Leu Val Lys Ile Lys Gln Glu Ile Leu Pro Glu Glu 
    130                 135                 140                 


Arg Met Asn Gly Gln Glu Val Phe Tyr Leu Xaa Tyr Xaa Pro Glu Asp 
145                 150                 155                 160 


Val Glu Gly Asn Val Gln Leu Glu Xaa Gly Asp Lys Ile Asn Phe Val 
                165                 170                 175     


Ile Asp Asn Asn Lys His Xaa Gly Ala Val Ser Ala Arg Asn Ile Met 
            180                 185                 190         


Leu Leu Lys Lys Lys Gln Ala Arg Cys Gln Gly Val Val Cys Ala Met 
        195                 200                 205             


Lys Glu Ala Phe Gly Phe Ile Glu Arg Gly Asp Val Val Lys Glu Ile 
    210                 215                 220                 


Phe Phe His Tyr Ser Glu Phe Lys Gly Asp Leu Glu Xaa Leu Gln Pro 
225                 230                 235                 240 


Gly Asp Asp Val Glu Phe Xaa Ile Lys Asp Arg Asn Gly Lys Glu Val 
                245                 250                 255     


Ala Xaa Asp Val Arg Leu Leu Pro Gln Gly Xaa Val Ile Phe Glu Asp 
            260                 265                 270         


Ile Ser Ile Glu His Phe Glu Gly Xaa Val Xaa Lys Val Ile Pro Lys 
        275                 280                 285             


Val Pro Ser Lys Asn Gln Asn Asp Pro Leu Pro Gly Arg Ile Lys Val 
    290                 295                 300                 


Asp Phe Val Ile Pro Lys Glu Leu Pro Phe Gly Asp Lys Asp Xaa Lys 
305                 310                 315                 320 


Ser Lys Val Xaa Leu Leu Glu Gly Asp His Val Arg Phe Asn Ile Ser 
                325                 330                 335     


Xaa Asp Arg Arg Asp Lys Leu Glu Arg Ala Xaa Asn Ile Glu Val Leu 
            340                 345                 350         


Ser Asn Xaa Phe Gln Phe Xaa Asn Glu Ala Arg Glu Met Gly Val Ile 
        355                 360                 365             


Ala Ala Met Arg Asp Gly Phe Gly Phe Ile Lys Cys Val Asp Arg Asp 
    370                 375                 380                 


Val Arg Met Phe Phe His Phe Ser Glu Ile Leu Asp Gly Asn Gln Leu 
385                 390                 395                 400 


His Ile Ala Asp Glu Val Glu Phe Xaa Val Val Pro Asp Met Leu Ser 
                405                 410                 415     


Ala Gln Arg Asn His Ala Ile Arg Ile Lys Lys Leu Pro Lys Gly Xaa 
            420                 425                 430         


Val Ser Phe His Ser His Ser Asp His Arg Phe Leu Gly Xaa Val Glu 
        435                 440                 445             


Lys Glu Ala Xaa Phe Ser Asn Pro Lys Xaa Xaa Ser Pro Asn Lys Gly 
    450                 455                 460                 


Lys Glu Lys Glu Ala Glu Asp Gly Ile Ile Ala Tyr Asp Asp Cys Gly 
465                 470                 475                 480 


Val Lys Leu Xaa Ile Ala Phe Gln Ala Lys Asp Val Glu Gly Ser Xaa 
                485                 490                 495     


Ser Pro Gln Ile Gly Asp Lys Val Glu Phe Ser Ile Ser Asp Lys Gln 
            500                 505                 510         


Arg Pro Gly Gln Gln Val Ala Xaa Cys Val Arg Leu Leu Gly Arg Asn 
        515                 520                 525             


Ser Asn Ser Lys Arg Leu Leu Gly Tyr Val Ala Xaa Leu Lys Asp Asn 
    530                 535                 540                 


Phe Gly Phe Ile Glu Xaa Ala Asn His Asp Lys Glu Ile Phe Phe His 
545                 550                 555                 560 


Tyr Ser Glu Phe Ser Gly Asp Val Asp Ser Leu Glu Leu Gly Asp Met 
                565                 570                 575     


Val Glu Tyr Ser Leu Ser Lys Gly Lys Gly Asn Lys Val Ser Ala Glu 
            580                 585                 590         


Lys Val Asn Lys Xaa His Ser Val Asn Gly Ile Xaa Glu Glu Ala Asp 
        595                 600                 605             


Pro Xaa Ile Tyr Ser Gly Lys Val Ile Arg Pro Leu Arg Ser Val Asp 
    610                 615                 620                 


Pro Xaa Gln Xaa Glu Tyr Gln Gly Met Ile Glu Ile Val Glu Glu Gly 
625                 630                 635                 640 


Asp Met Lys Gly Glu Val Tyr Pro Phe Gly Ile Val Gly Met Ala Asn 
                645                 650                 655     


Lys Gly Asp Cys Leu Gln Lys Gly Glu Ser Val Lys Phe Gln Leu Cys 
            660                 665                 670         


Val Leu Gly Gln Asn Ala Gln Xaa Met Ala Tyr Asn Ile Xaa Pro Leu 
        675                 680                 685             


Arg Arg Ala Xaa Val Glu Cys Val Lys Asp Gln Phe Gly Phe Ile Asn 
    690                 695                 700                 


Tyr Glu Val Gly Asp Ser Lys Lys Leu Phe Phe His Val Lys Glu Val 
705                 710                 715                 720 


Gln Asp Gly Ile Glu Leu Gln Ala Gly Asp Glu Val Glu Phe Ser Val 
                725                 730                 735     


Ile Leu Asn Gln Arg Xaa Gly Lys Cys Ser Ala Cys Asn Val Trp Arg 
            740                 745                 750         


Val Cys Glu Gly Pro Lys Ala Val Ala Ala Pro Arg Pro Asp Arg Leu 
        755                 760                 765             


Val Asn Arg Leu Lys Asn Ile Xaa Leu Asp Asp Ala Ser Ala Pro Arg 
    770                 775                 780                 


Leu Met Val Leu Arg Gln Pro Arg Gly Pro Asp Asn Ser Met Gly Phe 
785                 790                 795                 800 


Gly Ala Glu Arg Lys Ile Arg Gln Ala Gly Val Ile Asp 
                805                 810             


<210> 6997
<211> 844
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (723)..(723)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<400> 6997
Met Glu Asn Val Phe Xaa Val Ser Ser Asp Pro His Pro Ser Pro Ala 
1               5                   10                  15      


Ala Pro Pro Ser Leu Ser Leu Pro Leu Ser Ser Ser Ser Xaa Ser Ser 
            20                  25                  30          


Gly Xaa Lys Lys Gln Lys Arg Xaa Pro Xaa Tyr Gln Arg Ser Met Ser 
        35                  40                  45              


Phe Asp Pro Asn Leu Leu His Asn Asn Gly His Asn Gly Tyr Pro Asn 
    50                  55                  60                  


Gly Xaa Ser Ala Ala Leu Arg Glu Xaa Gly Val Ile Glu Lys Leu Leu 
65                  70                  75                  80  


Xaa Ser Tyr Gly Phe Ile Gln Cys Ser Glu Arg Gln Ala Arg Leu Phe 
                85                  90                  95      


Phe His Cys Ser Gln Tyr Asn Gly Asn Leu Gln Asp Leu Lys Val Gly 
            100                 105                 110         


Asp Asp Val Glu Phe Glu Val Ser Ser Asp Arg Arg Xaa Gly Lys Pro 
        115                 120                 125             


Ile Ala Val Lys Leu Val Lys Ile Lys Gln Glu Ile Leu Pro Glu Glu 
    130                 135                 140                 


Arg Met Asn Gly Gln Val Val Cys Ala Val Pro His Asn Leu Glu Ser 
145                 150                 155                 160 


Lys Ser Pro Ala Ala Pro Gly Gln Ser Pro Xaa Gly Ser Val Cys Tyr 
                165                 170                 175     


Glu Arg Asn Gly Glu Val Phe Tyr Leu Xaa Tyr Xaa Pro Glu Asp Val 
            180                 185                 190         


Glu Gly Asn Val Gln Leu Glu Xaa Gly Asp Lys Ile Asn Phe Val Ile 
        195                 200                 205             


Asp Asn Asn Lys His Xaa Gly Ala Val Ser Ala Arg Asn Ile Met Leu 
    210                 215                 220                 


Leu Lys Lys Lys Gln Ala Arg Cys Gln Gly Val Val Cys Ala Met Lys 
225                 230                 235                 240 


Glu Ala Phe Gly Phe Ile Glu Arg Gly Asp Val Val Lys Glu Ile Phe 
                245                 250                 255     


Phe His Tyr Ser Glu Phe Lys Gly Asp Leu Glu Xaa Leu Gln Pro Gly 
            260                 265                 270         


Asp Asp Val Glu Phe Xaa Ile Lys Asp Arg Asn Gly Lys Glu Val Ala 
        275                 280                 285             


Xaa Asp Val Arg Leu Leu Pro Gln Gly Xaa Val Ile Phe Glu Asp Ile 
    290                 295                 300                 


Ser Ile Glu His Phe Glu Gly Xaa Val Xaa Lys Val Ile Pro Lys Val 
305                 310                 315                 320 


Pro Ser Lys Asn Gln Asn Asp Pro Leu Pro Gly Arg Ile Lys Val Asp 
                325                 330                 335     


Phe Val Ile Pro Lys Glu Leu Pro Phe Gly Asp Lys Asp Xaa Lys Ser 
            340                 345                 350         


Lys Val Xaa Leu Leu Glu Gly Asp His Val Arg Phe Asn Ile Ser Xaa 
        355                 360                 365             


Asp Arg Arg Asp Lys Leu Glu Arg Ala Xaa Asn Ile Glu Val Leu Ser 
    370                 375                 380                 


Asn Xaa Phe Gln Phe Xaa Asn Glu Ala Arg Glu Met Gly Val Ile Ala 
385                 390                 395                 400 


Ala Met Arg Asp Gly Phe Gly Phe Ile Lys Cys Val Asp Arg Asp Val 
                405                 410                 415     


Arg Met Phe Phe His Phe Ser Glu Ile Leu Asp Gly Asn Gln Leu His 
            420                 425                 430         


Ile Ala Asp Glu Val Glu Phe Xaa Val Val Pro Asp Met Leu Ser Ala 
        435                 440                 445             


Gln Arg Asn His Ala Ile Arg Ile Lys Lys Leu Pro Lys Gly Xaa Val 
    450                 455                 460                 


Ser Phe His Ser His Ser Asp His Arg Phe Leu Gly Xaa Val Glu Lys 
465                 470                 475                 480 


Glu Ala Xaa Phe Ser Asn Pro Lys Xaa Xaa Ser Pro Asn Lys Gly Lys 
                485                 490                 495     


Glu Lys Glu Ala Glu Asp Gly Ile Ile Ala Tyr Asp Asp Cys Gly Val 
            500                 505                 510         


Lys Leu Xaa Ile Ala Phe Gln Ala Lys Asp Val Glu Gly Ser Xaa Ser 
        515                 520                 525             


Pro Gln Ile Gly Asp Lys Val Glu Phe Ser Ile Ser Asp Lys Gln Arg 
    530                 535                 540                 


Pro Gly Gln Gln Val Ala Xaa Cys Val Arg Leu Leu Gly Arg Asn Ser 
545                 550                 555                 560 


Asn Ser Lys Arg Leu Leu Gly Tyr Val Ala Xaa Leu Lys Asp Asn Phe 
                565                 570                 575     


Gly Phe Ile Glu Xaa Ala Asn His Asp Lys Glu Ile Phe Phe His Tyr 
            580                 585                 590         


Ser Glu Phe Ser Gly Asp Val Asp Ser Leu Glu Leu Gly Asp Met Val 
        595                 600                 605             


Glu Tyr Ser Leu Ser Lys Gly Lys Gly Asn Lys Val Ser Ala Glu Lys 
    610                 615                 620                 


Val Asn Lys Xaa His Ser Val Asn Gly Ile Xaa Glu Glu Ala Asp Pro 
625                 630                 635                 640 


Xaa Ile Tyr Ser Gly Lys Val Ile Arg Pro Leu Arg Ser Val Asp Pro 
                645                 650                 655     


Xaa Gln Xaa Glu Tyr Gln Gly Met Ile Glu Ile Val Glu Glu Gly Asp 
            660                 665                 670         


Met Lys Gly Glu Val Tyr Pro Phe Gly Ile Val Gly Met Ala Asn Lys 
        675                 680                 685             


Gly Asp Cys Leu Gln Lys Gly Glu Ser Val Lys Phe Gln Leu Cys Val 
    690                 695                 700                 


Leu Gly Gln Asn Ala Gln Xaa Met Ala Tyr Asn Ile Xaa Pro Leu Arg 
705                 710                 715                 720 


Arg Ala Xaa Val Glu Cys Val Lys Asp Gln Phe Gly Phe Ile Asn Tyr 
                725                 730                 735     


Glu Val Gly Asp Ser Lys Lys Leu Phe Phe His Val Lys Glu Val Gln 
            740                 745                 750         


Asp Gly Ile Glu Leu Gln Ala Gly Asp Glu Val Glu Phe Ser Val Ile 
        755                 760                 765             


Leu Asn Gln Arg Xaa Gly Lys Cys Ser Ala Cys Asn Val Trp Arg Val 
    770                 775                 780                 


Cys Glu Gly Pro Lys Ala Val Ala Ala Pro Arg Pro Asp Arg Leu Val 
785                 790                 795                 800 


Asn Arg Leu Lys Asn Ile Xaa Leu Asp Asp Ala Ser Ala Pro Arg Leu 
                805                 810                 815     


Met Val Leu Arg Gln Pro Arg Gly Pro Asp Asn Ser Met Gly Phe Gly 
            820                 825                 830         


Ala Glu Arg Lys Ile Arg Gln Ala Gly Val Ile Asp 
        835                 840                 


<210> 6998
<211> 36
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<400> 6998
Met Asn Gly Gln Glu Val Phe Tyr Leu Xaa Tyr Xaa Pro Glu Asp Val 
1               5                   10                  15      


Glu Gly Asn Val Gln Leu Glu Xaa Gly Asp Lys Ile Asn Phe Val Ile 
            20                  25                  30          


Asp Asn Asn Lys 
        35      


<210> 6999
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 6999
Met Asn Gly Gln Glu Val Phe Tyr Leu Xaa Tyr Xaa Pro Glu Asp Val 
1               5                   10                  15      


Glu Gly Asn Val Gln Leu Glu Xaa Gly Asp Lys Ile Asn Phe Val Ile 
            20                  25                  30          


Asp Asn Asn Lys His Xaa Gly Ala Val Ser Ala Arg Asn Ile Met Leu 
        35                  40                  45              


Leu Lys Lys Lys Gln Ala Arg Cys Gln Gly Val Val Cys Ala Met Lys 
    50                  55                  60                  


Glu Ala Phe Gly Phe Ile Glu Arg Gly Asp Val Val Lys Glu Ile Phe 
65                  70                  75                  80  


Phe His Tyr Ser Glu Phe Lys Gly Asp Leu Glu Xaa Leu Gln Pro Gly 
                85                  90                  95      


Asp Asp Val Glu Phe Xaa Ile Lys Asp Arg Asn Gly Lys Glu Val Ala 
            100                 105                 110         


Xaa Asp Val Arg Leu Leu Pro Gln Gly Xaa Val Ile Phe Glu Asp Ile 
        115                 120                 125             


Ser Ile Glu His Phe Glu Gly Xaa Val 
    130                 135         


<210> 7000
<211> 668
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<400> 7000
Met Asn Gly Gln Glu Val Phe Tyr Leu Xaa Tyr Xaa Pro Glu Asp Val 
1               5                   10                  15      


Glu Gly Asn Val Gln Leu Glu Xaa Gly Asp Lys Ile Asn Phe Val Ile 
            20                  25                  30          


Asp Asn Asn Lys His Xaa Gly Ala Val Ser Ala Arg Asn Ile Met Leu 
        35                  40                  45              


Leu Lys Lys Lys Gln Ala Arg Cys Gln Gly Val Val Cys Ala Met Lys 
    50                  55                  60                  


Glu Ala Phe Gly Phe Ile Glu Arg Gly Asp Val Val Lys Glu Ile Phe 
65                  70                  75                  80  


Phe His Tyr Ser Glu Phe Lys Gly Asp Leu Glu Xaa Leu Gln Pro Gly 
                85                  90                  95      


Asp Asp Val Glu Phe Xaa Ile Lys Asp Arg Asn Gly Lys Glu Val Ala 
            100                 105                 110         


Xaa Asp Val Arg Leu Leu Pro Gln Gly Xaa Val Ile Phe Glu Asp Ile 
        115                 120                 125             


Ser Ile Glu His Phe Glu Gly Xaa Val Xaa Lys Val Ile Pro Lys Val 
    130                 135                 140                 


Pro Ser Lys Asn Gln Asn Asp Pro Leu Pro Gly Arg Ile Lys Val Asp 
145                 150                 155                 160 


Phe Val Ile Pro Lys Glu Leu Pro Phe Gly Asp Lys Asp Xaa Lys Ser 
                165                 170                 175     


Lys Val Xaa Leu Leu Glu Gly Asp His Val Arg Phe Asn Ile Ser Xaa 
            180                 185                 190         


Asp Arg Arg Asp Lys Leu Glu Arg Ala Xaa Asn Ile Glu Val Leu Ser 
        195                 200                 205             


Asn Xaa Phe Gln Phe Xaa Asn Glu Ala Arg Glu Met Gly Val Ile Ala 
    210                 215                 220                 


Ala Met Arg Asp Gly Phe Gly Phe Ile Lys Cys Val Asp Arg Asp Val 
225                 230                 235                 240 


Arg Met Phe Phe His Phe Ser Glu Ile Leu Asp Gly Asn Gln Leu His 
                245                 250                 255     


Ile Ala Asp Glu Val Glu Phe Xaa Val Val Pro Asp Met Leu Ser Ala 
            260                 265                 270         


Gln Arg Asn His Ala Ile Arg Ile Lys Lys Leu Pro Lys Gly Xaa Val 
        275                 280                 285             


Ser Phe His Ser His Ser Asp His Arg Phe Leu Gly Xaa Val Glu Lys 
    290                 295                 300                 


Glu Ala Xaa Phe Ser Asn Pro Lys Xaa Xaa Ser Pro Asn Lys Gly Lys 
305                 310                 315                 320 


Glu Lys Glu Ala Glu Asp Gly Ile Ile Ala Tyr Asp Asp Cys Gly Val 
                325                 330                 335     


Lys Leu Xaa Ile Ala Phe Gln Ala Lys Asp Val Glu Gly Ser Xaa Ser 
            340                 345                 350         


Pro Gln Ile Gly Asp Lys Val Glu Phe Ser Ile Ser Asp Lys Gln Arg 
        355                 360                 365             


Pro Gly Gln Gln Val Ala Xaa Cys Val Arg Leu Leu Gly Arg Asn Ser 
    370                 375                 380                 


Asn Ser Lys Arg Leu Leu Gly Tyr Val Ala Xaa Leu Lys Asp Asn Phe 
385                 390                 395                 400 


Gly Phe Ile Glu Xaa Ala Asn His Asp Lys Glu Ile Phe Phe His Tyr 
                405                 410                 415     


Ser Glu Phe Ser Gly Asp Val Asp Ser Leu Glu Leu Gly Asp Met Val 
            420                 425                 430         


Glu Tyr Ser Leu Ser Lys Gly Lys Gly Asn Lys Val Ser Ala Glu Lys 
        435                 440                 445             


Val Asn Lys Xaa His Ser Val Asn Gly Ile Xaa Glu Glu Ala Asp Pro 
    450                 455                 460                 


Xaa Ile Tyr Ser Gly Lys Val Ile Arg Pro Leu Arg Ser Val Asp Pro 
465                 470                 475                 480 


Xaa Gln Xaa Glu Tyr Gln Gly Met Ile Glu Ile Val Glu Glu Gly Asp 
                485                 490                 495     


Met Lys Gly Glu Val Tyr Pro Phe Gly Ile Val Gly Met Ala Asn Lys 
            500                 505                 510         


Gly Asp Cys Leu Gln Lys Gly Glu Ser Val Lys Phe Gln Leu Cys Val 
        515                 520                 525             


Leu Gly Gln Asn Ala Gln Xaa Met Ala Tyr Asn Ile Xaa Pro Leu Arg 
    530                 535                 540                 


Arg Ala Xaa Val Glu Cys Val Lys Asp Gln Phe Gly Phe Ile Asn Tyr 
545                 550                 555                 560 


Glu Val Gly Asp Ser Lys Lys Leu Phe Phe His Val Lys Glu Val Gln 
                565                 570                 575     


Asp Gly Ile Glu Leu Gln Ala Gly Asp Glu Val Glu Phe Ser Val Ile 
            580                 585                 590         


Leu Asn Gln Arg Xaa Gly Lys Cys Ser Ala Cys Asn Val Trp Arg Val 
        595                 600                 605             


Cys Glu Gly Pro Lys Ala Val Ala Ala Pro Arg Pro Asp Arg Leu Val 
    610                 615                 620                 


Asn Arg Leu Lys Asn Ile Xaa Leu Asp Asp Ala Ser Ala Pro Arg Leu 
625                 630                 635                 640 


Met Val Leu Arg Gln Pro Arg Gly Pro Asp Asn Ser Met Gly Phe Gly 
                645                 650                 655     


Ala Glu Arg Lys Ile Arg Gln Ala Gly Val Ile Asp 
            660                 665             


<210> 7001
<211> 7
<212> PRT
<213> Homo sapiens

<400> 7001
Met Ser Phe Asp Pro Asn Leu 
1               5           


<210> 7002
<211> 46
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<400> 7002
Met Ser Phe Asp Pro Asn Leu Leu His Asn Asn Gly His Asn Gly Tyr 
1               5                   10                  15      


Pro Asn Gly Xaa Ser Ala Ala Leu Arg Glu Xaa Gly Val Ile Glu Lys 
            20                  25                  30          


Leu Leu Xaa Ser Tyr Gly Phe Ile Gln Cys Ser Glu Arg Gln 
        35                  40                  45      


<210> 7003
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<400> 7003
Met Ser Phe Asp Pro Asn Leu Leu His Asn Asn Gly His Asn Gly Tyr 
1               5                   10                  15      


Pro Asn Gly Xaa Ser Ala Ala Leu Arg Glu Xaa Gly Val Ile Glu Lys 
            20                  25                  30          


Leu Leu Xaa Ser Tyr Gly Phe Ile Gln Cys Ser Glu Arg Gln Ala Arg 
        35                  40                  45              


Leu Phe Phe His Cys Ser Gln Tyr Asn Gly Asn Leu Gln Asp Leu Lys 
    50                  55                  60                  


Val Gly Asp Asp Val Glu Phe Glu Val Ser Ser Asp Arg Arg Xaa Gly 
65                  70                  75                  80  


Lys Pro Ile Ala Val Lys Leu Val Lys Ile Lys Gln Glu Ile Leu 
                85                  90                  95  


<210> 7004
<211> 767
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<400> 7004
Met Ser Phe Asp Pro Asn Leu Leu His Asn Asn Gly His Asn Gly Tyr 
1               5                   10                  15      


Pro Asn Gly Xaa Ser Ala Ala Leu Arg Glu Xaa Gly Val Ile Glu Lys 
            20                  25                  30          


Leu Leu Xaa Ser Tyr Gly Phe Ile Gln Cys Ser Glu Arg Gln Ala Arg 
        35                  40                  45              


Leu Phe Phe His Cys Ser Gln Tyr Asn Gly Asn Leu Gln Asp Leu Lys 
    50                  55                  60                  


Val Gly Asp Asp Val Glu Phe Glu Val Ser Ser Asp Arg Arg Xaa Gly 
65                  70                  75                  80  


Lys Pro Ile Ala Val Lys Leu Val Lys Ile Lys Gln Glu Ile Leu Pro 
                85                  90                  95      


Glu Glu Arg Met Asn Gly Gln Glu Val Phe Tyr Leu Xaa Tyr Xaa Pro 
            100                 105                 110         


Glu Asp Val Glu Gly Asn Val Gln Leu Glu Xaa Gly Asp Lys Ile Asn 
        115                 120                 125             


Phe Val Ile Asp Asn Asn Lys His Xaa Gly Ala Val Ser Ala Arg Asn 
    130                 135                 140                 


Ile Met Leu Leu Lys Lys Lys Gln Ala Arg Cys Gln Gly Val Val Cys 
145                 150                 155                 160 


Ala Met Lys Glu Ala Phe Gly Phe Ile Glu Arg Gly Asp Val Val Lys 
                165                 170                 175     


Glu Ile Phe Phe His Tyr Ser Glu Phe Lys Gly Asp Leu Glu Xaa Leu 
            180                 185                 190         


Gln Pro Gly Asp Asp Val Glu Phe Xaa Ile Lys Asp Arg Asn Gly Lys 
        195                 200                 205             


Glu Val Ala Xaa Asp Val Arg Leu Leu Pro Gln Gly Xaa Val Ile Phe 
    210                 215                 220                 


Glu Asp Ile Ser Ile Glu His Phe Glu Gly Xaa Val Xaa Lys Val Ile 
225                 230                 235                 240 


Pro Lys Val Pro Ser Lys Asn Gln Asn Asp Pro Leu Pro Gly Arg Ile 
                245                 250                 255     


Lys Val Asp Phe Val Ile Pro Lys Glu Leu Pro Phe Gly Asp Lys Asp 
            260                 265                 270         


Xaa Lys Ser Lys Val Xaa Leu Leu Glu Gly Asp His Val Arg Phe Asn 
        275                 280                 285             


Ile Ser Xaa Asp Arg Arg Asp Lys Leu Glu Arg Ala Xaa Asn Ile Glu 
    290                 295                 300                 


Val Leu Ser Asn Xaa Phe Gln Phe Xaa Asn Glu Ala Arg Glu Met Gly 
305                 310                 315                 320 


Val Ile Ala Ala Met Arg Asp Gly Phe Gly Phe Ile Lys Cys Val Asp 
                325                 330                 335     


Arg Asp Val Arg Met Phe Phe His Phe Ser Glu Ile Leu Asp Gly Asn 
            340                 345                 350         


Gln Leu His Ile Ala Asp Glu Val Glu Phe Xaa Val Val Pro Asp Met 
        355                 360                 365             


Leu Ser Ala Gln Arg Asn His Ala Ile Arg Ile Lys Lys Leu Pro Lys 
    370                 375                 380                 


Gly Xaa Val Ser Phe His Ser His Ser Asp His Arg Phe Leu Gly Xaa 
385                 390                 395                 400 


Val Glu Lys Glu Ala Xaa Phe Ser Asn Pro Lys Xaa Xaa Ser Pro Asn 
                405                 410                 415     


Lys Gly Lys Glu Lys Glu Ala Glu Asp Gly Ile Ile Ala Tyr Asp Asp 
            420                 425                 430         


Cys Gly Val Lys Leu Xaa Ile Ala Phe Gln Ala Lys Asp Val Glu Gly 
        435                 440                 445             


Ser Xaa Ser Pro Gln Ile Gly Asp Lys Val Glu Phe Ser Ile Ser Asp 
    450                 455                 460                 


Lys Gln Arg Pro Gly Gln Gln Val Ala Xaa Cys Val Arg Leu Leu Gly 
465                 470                 475                 480 


Arg Asn Ser Asn Ser Lys Arg Leu Leu Gly Tyr Val Ala Xaa Leu Lys 
                485                 490                 495     


Asp Asn Phe Gly Phe Ile Glu Xaa Ala Asn His Asp Lys Glu Ile Phe 
            500                 505                 510         


Phe His Tyr Ser Glu Phe Ser Gly Asp Val Asp Ser Leu Glu Leu Gly 
        515                 520                 525             


Asp Met Val Glu Tyr Ser Leu Ser Lys Gly Lys Gly Asn Lys Val Ser 
    530                 535                 540                 


Ala Glu Lys Val Asn Lys Xaa His Ser Val Asn Gly Ile Xaa Glu Glu 
545                 550                 555                 560 


Ala Asp Pro Xaa Ile Tyr Ser Gly Lys Val Ile Arg Pro Leu Arg Ser 
                565                 570                 575     


Val Asp Pro Xaa Gln Xaa Glu Tyr Gln Gly Met Ile Glu Ile Val Glu 
            580                 585                 590         


Glu Gly Asp Met Lys Gly Glu Val Tyr Pro Phe Gly Ile Val Gly Met 
        595                 600                 605             


Ala Asn Lys Gly Asp Cys Leu Gln Lys Gly Glu Ser Val Lys Phe Gln 
    610                 615                 620                 


Leu Cys Val Leu Gly Gln Asn Ala Gln Xaa Met Ala Tyr Asn Ile Xaa 
625                 630                 635                 640 


Pro Leu Arg Arg Ala Xaa Val Glu Cys Val Lys Asp Gln Phe Gly Phe 
                645                 650                 655     


Ile Asn Tyr Glu Val Gly Asp Ser Lys Lys Leu Phe Phe His Val Lys 
            660                 665                 670         


Glu Val Gln Asp Gly Ile Glu Leu Gln Ala Gly Asp Glu Val Glu Phe 
        675                 680                 685             


Ser Val Ile Leu Asn Gln Arg Xaa Gly Lys Cys Ser Ala Cys Asn Val 
    690                 695                 700                 


Trp Arg Val Cys Glu Gly Pro Lys Ala Val Ala Ala Pro Arg Pro Asp 
705                 710                 715                 720 


Arg Leu Val Asn Arg Leu Lys Asn Ile Xaa Leu Asp Asp Ala Ser Ala 
                725                 730                 735     


Pro Arg Leu Met Val Leu Arg Gln Pro Arg Gly Pro Asp Asn Ser Met 
            740                 745                 750         


Gly Phe Gly Ala Glu Arg Lys Ile Arg Gln Ala Gly Val Ile Asp 
        755                 760                 765         


<210> 7005
<211> 798
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<400> 7005
Met Ser Phe Asp Pro Asn Leu Leu His Asn Asn Gly His Asn Gly Tyr 
1               5                   10                  15      


Pro Asn Gly Xaa Ser Ala Ala Leu Arg Glu Xaa Gly Val Ile Glu Lys 
            20                  25                  30          


Leu Leu Xaa Ser Tyr Gly Phe Ile Gln Cys Ser Glu Arg Gln Ala Arg 
        35                  40                  45              


Leu Phe Phe His Cys Ser Gln Tyr Asn Gly Asn Leu Gln Asp Leu Lys 
    50                  55                  60                  


Val Gly Asp Asp Val Glu Phe Glu Val Ser Ser Asp Arg Arg Xaa Gly 
65                  70                  75                  80  


Lys Pro Ile Ala Val Lys Leu Val Lys Ile Lys Gln Glu Ile Leu Pro 
                85                  90                  95      


Glu Glu Arg Met Asn Gly Gln Val Val Cys Ala Val Pro His Asn Leu 
            100                 105                 110         


Glu Ser Lys Ser Pro Ala Ala Pro Gly Gln Ser Pro Xaa Gly Ser Val 
        115                 120                 125             


Cys Tyr Glu Arg Asn Gly Glu Val Phe Tyr Leu Xaa Tyr Xaa Pro Glu 
    130                 135                 140                 


Asp Val Glu Gly Asn Val Gln Leu Glu Xaa Gly Asp Lys Ile Asn Phe 
145                 150                 155                 160 


Val Ile Asp Asn Asn Lys His Xaa Gly Ala Val Ser Ala Arg Asn Ile 
                165                 170                 175     


Met Leu Leu Lys Lys Lys Gln Ala Arg Cys Gln Gly Val Val Cys Ala 
            180                 185                 190         


Met Lys Glu Ala Phe Gly Phe Ile Glu Arg Gly Asp Val Val Lys Glu 
        195                 200                 205             


Ile Phe Phe His Tyr Ser Glu Phe Lys Gly Asp Leu Glu Xaa Leu Gln 
    210                 215                 220                 


Pro Gly Asp Asp Val Glu Phe Xaa Ile Lys Asp Arg Asn Gly Lys Glu 
225                 230                 235                 240 


Val Ala Xaa Asp Val Arg Leu Leu Pro Gln Gly Xaa Val Ile Phe Glu 
                245                 250                 255     


Asp Ile Ser Ile Glu His Phe Glu Gly Xaa Val Xaa Lys Val Ile Pro 
            260                 265                 270         


Lys Val Pro Ser Lys Asn Gln Asn Asp Pro Leu Pro Gly Arg Ile Lys 
        275                 280                 285             


Val Asp Phe Val Ile Pro Lys Glu Leu Pro Phe Gly Asp Lys Asp Xaa 
    290                 295                 300                 


Lys Ser Lys Val Xaa Leu Leu Glu Gly Asp His Val Arg Phe Asn Ile 
305                 310                 315                 320 


Ser Xaa Asp Arg Arg Asp Lys Leu Glu Arg Ala Xaa Asn Ile Glu Val 
                325                 330                 335     


Leu Ser Asn Xaa Phe Gln Phe Xaa Asn Glu Ala Arg Glu Met Gly Val 
            340                 345                 350         


Ile Ala Ala Met Arg Asp Gly Phe Gly Phe Ile Lys Cys Val Asp Arg 
        355                 360                 365             


Asp Val Arg Met Phe Phe His Phe Ser Glu Ile Leu Asp Gly Asn Gln 
    370                 375                 380                 


Leu His Ile Ala Asp Glu Val Glu Phe Xaa Val Val Pro Asp Met Leu 
385                 390                 395                 400 


Ser Ala Gln Arg Asn His Ala Ile Arg Ile Lys Lys Leu Pro Lys Gly 
                405                 410                 415     


Xaa Val Ser Phe His Ser His Ser Asp His Arg Phe Leu Gly Xaa Val 
            420                 425                 430         


Glu Lys Glu Ala Xaa Phe Ser Asn Pro Lys Xaa Xaa Ser Pro Asn Lys 
        435                 440                 445             


Gly Lys Glu Lys Glu Ala Glu Asp Gly Ile Ile Ala Tyr Asp Asp Cys 
    450                 455                 460                 


Gly Val Lys Leu Xaa Ile Ala Phe Gln Ala Lys Asp Val Glu Gly Ser 
465                 470                 475                 480 


Xaa Ser Pro Gln Ile Gly Asp Lys Val Glu Phe Ser Ile Ser Asp Lys 
                485                 490                 495     


Gln Arg Pro Gly Gln Gln Val Ala Xaa Cys Val Arg Leu Leu Gly Arg 
            500                 505                 510         


Asn Ser Asn Ser Lys Arg Leu Leu Gly Tyr Val Ala Xaa Leu Lys Asp 
        515                 520                 525             


Asn Phe Gly Phe Ile Glu Xaa Ala Asn His Asp Lys Glu Ile Phe Phe 
    530                 535                 540                 


His Tyr Ser Glu Phe Ser Gly Asp Val Asp Ser Leu Glu Leu Gly Asp 
545                 550                 555                 560 


Met Val Glu Tyr Ser Leu Ser Lys Gly Lys Gly Asn Lys Val Ser Ala 
                565                 570                 575     


Glu Lys Val Asn Lys Xaa His Ser Val Asn Gly Ile Xaa Glu Glu Ala 
            580                 585                 590         


Asp Pro Xaa Ile Tyr Ser Gly Lys Val Ile Arg Pro Leu Arg Ser Val 
        595                 600                 605             


Asp Pro Xaa Gln Xaa Glu Tyr Gln Gly Met Ile Glu Ile Val Glu Glu 
    610                 615                 620                 


Gly Asp Met Lys Gly Glu Val Tyr Pro Phe Gly Ile Val Gly Met Ala 
625                 630                 635                 640 


Asn Lys Gly Asp Cys Leu Gln Lys Gly Glu Ser Val Lys Phe Gln Leu 
                645                 650                 655     


Cys Val Leu Gly Gln Asn Ala Gln Xaa Met Ala Tyr Asn Ile Xaa Pro 
            660                 665                 670         


Leu Arg Arg Ala Xaa Val Glu Cys Val Lys Asp Gln Phe Gly Phe Ile 
        675                 680                 685             


Asn Tyr Glu Val Gly Asp Ser Lys Lys Leu Phe Phe His Val Lys Glu 
    690                 695                 700                 


Val Gln Asp Gly Ile Glu Leu Gln Ala Gly Asp Glu Val Glu Phe Ser 
705                 710                 715                 720 


Val Ile Leu Asn Gln Arg Xaa Gly Lys Cys Ser Ala Cys Asn Val Trp 
                725                 730                 735     


Arg Val Cys Glu Gly Pro Lys Ala Val Ala Ala Pro Arg Pro Asp Arg 
            740                 745                 750         


Leu Val Asn Arg Leu Lys Asn Ile Xaa Leu Asp Asp Ala Ser Ala Pro 
        755                 760                 765             


Arg Leu Met Val Leu Arg Gln Pro Arg Gly Pro Asp Asn Ser Met Gly 
    770                 775                 780                 


Phe Gly Ala Glu Arg Lys Ile Arg Gln Ala Gly Val Ile Asp 
785                 790                 795             


<210> 7006
<211> 915
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<400> 7006
Met Glu Leu Ser Asp Ala Asn Leu Gln Xaa Leu Xaa Glu Tyr Leu Lys 
1               5                   10                  15      


Lys Xaa Leu Asp Pro Asp Pro Ala Ile Arg Arg Pro Ala Glu Lys Phe 
            20                  25                  30          


Leu Glu Ser Val Glu Gly Asn Gln Asn Tyr Pro Leu Leu Leu Leu Xaa 
        35                  40                  45              


Leu Leu Glu Lys Ser Gln Asp Asn Val Ile Lys Val Cys Ala Ser Val 
    50                  55                  60                  


Xaa Phe Lys Asn Tyr Ile Lys Arg Asn Trp Arg Ile Val Glu Asp Glu 
65                  70                  75                  80  


Pro Asn Lys Ile Cys Glu Ala Asp Arg Val Ala Ile Lys Ala Asn Ile 
                85                  90                  95      


Val His Leu Met Leu Ser Ser Pro Glu Gln Ile Gln Lys Gln Leu Ser 
            100                 105                 110         


Asp Ala Ile Ser Ile Ile Gly Arg Glu Asp Phe Pro Gln Lys Trp Pro 
        115                 120                 125             


Asp Leu Leu Xaa Glu Met Val Asn Arg Phe Gln Ser Gly Asp Phe His 
    130                 135                 140                 


Val Ile Asn Gly Val Leu Arg Xaa Ala His Ser Leu Phe Lys Arg Tyr 
145                 150                 155                 160 


Arg His Glu Phe Lys Ser Asn Glu Leu Trp Xaa Glu Ile Lys Leu Val 
                165                 170                 175     


Leu Asp Ala Phe Ala Leu Pro Leu Xaa Asn Leu Phe Lys Ala Xaa Ile 
            180                 185                 190         


Glu Leu Cys Ser Xaa His Ala Asn Asp Ala Ser Ala Leu Arg Ile Leu 
        195                 200                 205             


Phe Ser Ser Leu Ile Leu Ile Ser Lys Leu Phe Tyr Ser Leu Asn Phe 
    210                 215                 220                 


Gln Asp Leu Pro Glu Phe Phe Glu Asp Asn Met Glu Xaa Trp Met Asn 
225                 230                 235                 240 


Asn Phe His Xaa Leu Leu Xaa Leu Asp Asn Lys Leu Leu Gln Xaa Asp 
                245                 250                 255     


Leu Val Ser Asn Ala Ile Gln Phe Leu Ala Ser Val Cys Glu Arg Pro 
            260                 265                 270         


His Tyr Lys Asn Leu Phe Glu Asp Gln Asn Xaa Leu Xaa Ser Ile Cys 
        275                 280                 285             


Glu Lys Val Ile Val Pro Asn Met Glu Phe Arg Ala Ala Asp Glu Glu 
    290                 295                 300                 


Ala Phe Glu Asp Asn Ser Glu Glu Tyr Ile Arg Arg Asp Leu Glu Gly 
305                 310                 315                 320 


Ser Asp Ile Asp Xaa Arg Arg Arg Ala Ala Cys Asp Leu Val Arg Gly 
                325                 330                 335     


Leu Cys Lys Phe Phe Glu Gly Pro Val Xaa Gly Ile Phe Ser Gly Tyr 
            340                 345                 350         


Val Asn Ser Met Leu Gln Glu Tyr Ala Lys Asn Pro Ser Val Asn Trp 
        355                 360                 365             


Lys His Lys Asp Ala Ala Ile Tyr Leu Val Xaa Ser Leu Ala Ser Lys 
    370                 375                 380                 


Ala Gln Xaa Gln Lys His Gly Ile Xaa Gln Ala Asn Glu Leu Val Asn 
385                 390                 395                 400 


Leu Xaa Glu Phe Phe Val Asn His Ile Leu Pro Asp Leu Lys Ser Ala 
                405                 410                 415     


Asn Val Asn Glu Phe Pro Val Leu Lys Ala Asp Gly Ile Lys Tyr Ile 
            420                 425                 430         


Met Ile Phe Arg Asn Gln Val Pro Lys Glu His Leu Leu Val Ser Ile 
        435                 440                 445             


Pro Leu Leu Ile Asn His Leu Gln Ala Glu Ser Ile Val Val His Xaa 
    450                 455                 460                 


Tyr Ala Ala His Ala Leu Glu Arg Leu Phe Xaa Met Arg Gly Pro Asn 
465                 470                 475                 480 


Asn Ala Xaa Leu Phe Xaa Ala Ala Glu Ile Ala Pro Phe Val Glu Ile 
                485                 490                 495     


Leu Leu Xaa Asn Leu Phe Lys Ala Leu Xaa Leu Pro Gly Ser Ser Glu 
            500                 505                 510         


Asn Glu Tyr Ile Met Lys Ala Ile Met Arg Ser Phe Ser Leu Leu Gln 
        515                 520                 525             


Glu Ala Ile Ile Pro Tyr Ile Pro Xaa Leu Ile Xaa Gln Leu Xaa Gln 
    530                 535                 540                 


Lys Leu Leu Ala Val Ser Lys Asn Pro Ser Lys Pro His Phe Asn His 
545                 550                 555                 560 


Tyr Met Phe Glu Ala Ile Cys Leu Ser Ile Arg Ile Xaa Cys Lys Ala 
                565                 570                 575     


Asn Pro Ala Ala Val Val Asn Phe Glu Glu Ala Leu Phe Leu Val Phe 
            580                 585                 590         


Xaa Glu Ile Leu Gln Asn Asp Val Gln Glu Phe Ile Pro Tyr Val Phe 
        595                 600                 605             


Gln Val Met Ser Leu Leu Leu Glu Xaa His Lys Asn Asp Ile Pro Ser 
    610                 615                 620                 


Ser Tyr Met Ala Leu Phe Pro His Leu Leu Gln Pro Val Leu Trp Glu 
625                 630                 635                 640 


Arg Xaa Gly Asn Ile Pro Ala Leu Val Arg Leu Leu Gln Ala Phe Leu 
                645                 650                 655     


Glu Arg Gly Ser Asn Xaa Ile Ala Ser Ala Ala Ala Asp Lys Ile Pro 
            660                 665                 670         


Gly Leu Leu Gly Val Phe Gln Lys Leu Ile Ala Ser Lys Ala Asn Asp 
        675                 680                 685             


His Gln Gly Phe Tyr Leu Leu Asn Ser Ile Ile Glu His Met Pro Pro 
    690                 695                 700                 


Glu Ser Val Asp Gln Tyr Arg Lys Gln Ile Phe Ile Leu Leu Phe Gln 
705                 710                 715                 720 


Arg Leu Gln Asn Ser Lys Xaa Xaa Lys Phe Ile Lys Ser Phe Leu Val 
                725                 730                 735     


Phe Ile Asn Leu Tyr Cys Ile Lys Tyr Gly Ala Leu Ala Leu Gln Glu 
            740                 745                 750         


Ile Phe Asp Gly Ile Gln Pro Lys Met Phe Gly Met Val Leu Glu Lys 
        755                 760                 765             


Ile Ile Ile Pro Glu Ile Gln Lys Val Ser Gly Asn Val Glu Lys Lys 
    770                 775                 780                 


Ile Cys Ala Val Gly Ile Xaa Lys Leu Leu Xaa Glu Cys Pro Pro Met 
785                 790                 795                 800 


Met Asp Xaa Glu Tyr Xaa Lys Leu Trp Xaa Pro Leu Leu Gln Ser Leu 
                805                 810                 815     


Ile Gly Leu Phe Glu Leu Pro Glu Asp Asp Xaa Ile Pro Asp Glu Glu 
            820                 825                 830         


His Phe Ile Asp Ile Glu Asp Xaa Pro Gly Tyr Gln Xaa Ala Phe Ser 
        835                 840                 845             


Gln Leu Ala Phe Ala Gly Lys Lys Glu His Asp Pro Val Gly Gln Met 
    850                 855                 860                 


Val Asn Asn Pro Lys Ile His Leu Ala Gln Ser Leu His Lys Leu Ser 
865                 870                 875                 880 


Xaa Ala Cys Pro Gly Arg Val Pro Ser Met Val Ser Xaa Ser Leu Asn 
                885                 890                 895     


Ala Glu Ala Leu Gln Tyr Leu Gln Gly Tyr Leu Gln Ala Ala Ser Val 
            900                 905                 910         


Xaa Leu Leu 
        915 


<210> 7007
<211> 971
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (718)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<400> 7007
Met Glu Leu Ser Asp Ala Asn Leu Gln Xaa Leu Xaa Glu Tyr Leu Lys 
1               5                   10                  15      


Lys Xaa Leu Asp Pro Asp Pro Ala Ile Arg Arg Pro Ala Glu Lys Phe 
            20                  25                  30          


Leu Glu Ser Val Glu Gly Asn Gln Asn Tyr Pro Leu Leu Leu Leu Xaa 
        35                  40                  45              


Leu Leu Glu Lys Ser Gln Asp Asn Val Ile Lys Val Cys Ala Ser Val 
    50                  55                  60                  


Xaa Phe Lys Asn Tyr Ile Lys Arg Asn Trp Arg Ile Val Glu Asp Glu 
65                  70                  75                  80  


Pro Asn Lys Ile Cys Glu Ala Asp Arg Val Ala Ile Lys Ala Asn Ile 
                85                  90                  95      


Val His Leu Met Leu Ser Ser Pro Glu Gln Ile Gln Lys Gln Leu Ser 
            100                 105                 110         


Asp Ala Ile Ser Ile Ile Gly Arg Glu Asp Phe Pro Gln Lys Trp Pro 
        115                 120                 125             


Asp Leu Leu Xaa Glu Met Val Asn Arg Phe Gln Ser Gly Asp Phe His 
    130                 135                 140                 


Val Ile Asn Gly Val Leu Arg Xaa Ala His Ser Leu Phe Lys Arg Tyr 
145                 150                 155                 160 


Arg His Glu Phe Lys Ser Asn Glu Leu Trp Xaa Glu Ile Lys Leu Val 
                165                 170                 175     


Leu Asp Ala Phe Ala Leu Pro Leu Xaa Asn Leu Phe Lys Ala Xaa Ile 
            180                 185                 190         


Glu Leu Cys Ser Xaa His Ala Asn Asp Ala Ser Ala Leu Arg Ile Leu 
        195                 200                 205             


Phe Ser Ser Leu Ile Leu Ile Ser Lys Leu Phe Tyr Ser Leu Asn Phe 
    210                 215                 220                 


Gln Asp Leu Pro Glu Phe Phe Glu Asp Asn Met Glu Xaa Trp Met Asn 
225                 230                 235                 240 


Asn Phe His Xaa Leu Leu Xaa Leu Asp Asn Lys Leu Leu Gln Xaa Asp 
                245                 250                 255     


Asp Glu Glu Glu Ala Gly Leu Leu Glu Leu Leu Lys Ser Gln Ile Cys 
            260                 265                 270         


Asp Asn Ala Ala Leu Tyr Ala Gln Lys Tyr Asp Glu Glu Phe Gln Arg 
        275                 280                 285             


Tyr Leu Pro Arg Phe Val Xaa Ala Ile Trp Asn Leu Leu Val Xaa Xaa 
    290                 295                 300                 


Gly Gln Glu Val Lys Tyr Asp Leu Leu Val Ser Asn Ala Ile Gln Phe 
305                 310                 315                 320 


Leu Ala Ser Val Cys Glu Arg Pro His Tyr Lys Asn Leu Phe Glu Asp 
                325                 330                 335     


Gln Asn Xaa Leu Xaa Ser Ile Cys Glu Lys Val Ile Val Pro Asn Met 
            340                 345                 350         


Glu Phe Arg Ala Ala Asp Glu Glu Ala Phe Glu Asp Asn Ser Glu Glu 
        355                 360                 365             


Tyr Ile Arg Arg Asp Leu Glu Gly Ser Asp Ile Asp Xaa Arg Arg Arg 
    370                 375                 380                 


Ala Ala Cys Asp Leu Val Arg Gly Leu Cys Lys Phe Phe Glu Gly Pro 
385                 390                 395                 400 


Val Xaa Gly Ile Phe Ser Gly Tyr Val Asn Ser Met Leu Gln Glu Tyr 
                405                 410                 415     


Ala Lys Asn Pro Ser Val Asn Trp Lys His Lys Asp Ala Ala Ile Tyr 
            420                 425                 430         


Leu Val Xaa Ser Leu Ala Ser Lys Ala Gln Xaa Gln Lys His Gly Ile 
        435                 440                 445             


Xaa Gln Ala Asn Glu Leu Val Asn Leu Xaa Glu Phe Phe Val Asn His 
    450                 455                 460                 


Ile Leu Pro Asp Leu Lys Ser Ala Asn Val Asn Glu Phe Pro Val Leu 
465                 470                 475                 480 


Lys Ala Asp Gly Ile Lys Tyr Ile Met Ile Phe Arg Asn Gln Val Pro 
                485                 490                 495     


Lys Glu His Leu Leu Val Ser Ile Pro Leu Leu Ile Asn His Leu Gln 
            500                 505                 510         


Ala Glu Ser Ile Val Val His Xaa Tyr Ala Ala His Ala Leu Glu Arg 
        515                 520                 525             


Leu Phe Xaa Met Arg Gly Pro Asn Asn Ala Xaa Leu Phe Xaa Ala Ala 
    530                 535                 540                 


Glu Ile Ala Pro Phe Val Glu Ile Leu Leu Xaa Asn Leu Phe Lys Ala 
545                 550                 555                 560 


Leu Xaa Leu Pro Gly Ser Ser Glu Asn Glu Tyr Ile Met Lys Ala Ile 
                565                 570                 575     


Met Arg Ser Phe Ser Leu Leu Gln Glu Ala Ile Ile Pro Tyr Ile Pro 
            580                 585                 590         


Xaa Leu Ile Xaa Gln Leu Xaa Gln Lys Leu Leu Ala Val Ser Lys Asn 
        595                 600                 605             


Pro Ser Lys Pro His Phe Asn His Tyr Met Phe Glu Ala Ile Cys Leu 
    610                 615                 620                 


Ser Ile Arg Ile Xaa Cys Lys Ala Asn Pro Ala Ala Val Val Asn Phe 
625                 630                 635                 640 


Glu Glu Ala Leu Phe Leu Val Phe Xaa Glu Ile Leu Gln Asn Asp Val 
                645                 650                 655     


Gln Glu Phe Ile Pro Tyr Val Phe Gln Val Met Ser Leu Leu Leu Glu 
            660                 665                 670         


Xaa His Lys Asn Asp Ile Pro Ser Ser Tyr Met Ala Leu Phe Pro His 
        675                 680                 685             


Leu Leu Gln Pro Val Leu Trp Glu Arg Xaa Gly Asn Ile Pro Ala Leu 
    690                 695                 700                 


Val Arg Leu Leu Gln Ala Phe Leu Glu Arg Gly Ser Asn Xaa Ile Ala 
705                 710                 715                 720 


Ser Ala Ala Ala Asp Lys Ile Pro Gly Leu Leu Gly Val Phe Gln Lys 
                725                 730                 735     


Leu Ile Ala Ser Lys Ala Asn Asp His Gln Gly Phe Tyr Leu Leu Asn 
            740                 745                 750         


Ser Ile Ile Glu His Met Pro Pro Glu Ser Val Asp Gln Tyr Arg Lys 
        755                 760                 765             


Gln Ile Phe Ile Leu Leu Phe Gln Arg Leu Gln Asn Ser Lys Xaa Xaa 
    770                 775                 780                 


Lys Phe Ile Lys Ser Phe Leu Val Phe Ile Asn Leu Tyr Cys Ile Lys 
785                 790                 795                 800 


Tyr Gly Ala Leu Ala Leu Gln Glu Ile Phe Asp Gly Ile Gln Pro Lys 
                805                 810                 815     


Met Phe Gly Met Val Leu Glu Lys Ile Ile Ile Pro Glu Ile Gln Lys 
            820                 825                 830         


Val Ser Gly Asn Val Glu Lys Lys Ile Cys Ala Val Gly Ile Xaa Lys 
        835                 840                 845             


Leu Leu Xaa Glu Cys Pro Pro Met Met Asp Xaa Glu Tyr Xaa Lys Leu 
    850                 855                 860                 


Trp Xaa Pro Leu Leu Gln Ser Leu Ile Gly Leu Phe Glu Leu Pro Glu 
865                 870                 875                 880 


Asp Asp Xaa Ile Pro Asp Glu Glu His Phe Ile Asp Ile Glu Asp Xaa 
                885                 890                 895     


Pro Gly Tyr Gln Xaa Ala Phe Ser Gln Leu Ala Phe Ala Gly Lys Lys 
            900                 905                 910         


Glu His Asp Pro Val Gly Gln Met Val Asn Asn Pro Lys Ile His Leu 
        915                 920                 925             


Ala Gln Ser Leu His Lys Leu Ser Xaa Ala Cys Pro Gly Arg Val Pro 
    930                 935                 940                 


Ser Met Val Ser Xaa Ser Leu Asn Ala Glu Ala Leu Gln Tyr Leu Gln 
945                 950                 955                 960 


Gly Tyr Leu Gln Ala Ala Ser Val Xaa Leu Leu 
                965                 970     


<210> 7008
<211> 150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 7008
Met Gly Trp Gly Arg Leu Gln Arg Ile Ser Leu Pro Ser Gln Cys Leu 
1               5                   10                  15      


Ser Leu Leu Ser Xaa Trp Leu Gly Ser Leu Leu Leu Leu Val Cys Leu 
            20                  25                  30          


Leu Ala Ser Arg Ser Ile Xaa Glu Glu Val Ser Glu Tyr Cys Ser His 
        35                  40                  45              


Met Ile Gly Ser Gly His Leu Gln Ser Leu Gln Arg Leu Ile Asp Ser 
    50                  55                  60                  


Gln Met Glu Xaa Ser Cys Gln Ile Xaa Phe Glu Phe Val Asp Gln Glu 
65                  70                  75                  80  


Gln Leu Lys Asp Pro Val Cys Tyr Leu Lys Lys Ala Phe Leu Leu Val 
                85                  90                  95      


Gln Asp Ile Met Glu Asp Xaa Met Arg Phe Arg Asp Asn Xaa Pro Asn 
            100                 105                 110         


Ala Ile Ala Ile Val Gln Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser 
        115                 120                 125             


Cys Phe Xaa Lys Asp Tyr Glu Glu His Asp Lys Ala Cys Val Arg Xaa 
    130                 135                 140                 


Phe Tyr Glu Xaa Pro Leu 
145                 150 


<210> 7009
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<400> 7009
Met Ile Gly Ser Gly His Leu Gln Ser Leu Gln Arg Leu Ile Asp Ser 
1               5                   10                  15      


Gln Met Glu Xaa Ser Cys Gln Ile Xaa Phe Glu Phe Val Asp Gln Glu 
            20                  25                  30          


Gln Leu Lys Asp Pro Val Cys Tyr Leu Lys Lys Ala Phe Leu Leu Val 
        35                  40                  45              


Gln Asp Ile Met Glu Asp Xaa Met Arg Phe Arg Asp Asn Xaa Pro Asn 
    50                  55                  60                  


Ala Ile Ala Ile Val Gln Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser 
65                  70                  75                  80  


Cys Phe Xaa Lys Asp Tyr Glu Glu His Asp Lys Ala Cys Val Arg Xaa 
                85                  90                  95      


Phe Tyr Glu Xaa Pro Leu Gln Leu Leu Glu Lys Val Lys Asn Val Phe 
            100                 105                 110         


Asn 
    


<210> 7010
<211> 285
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<400> 7010
Met Xaa Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Xaa Ile Asp Ser 
1               5                   10                  15      


Gln Met Glu Xaa Ser Cys Gln Ile Xaa Phe Glu Phe Val Asp Gln Glu 
            20                  25                  30          


Gln Leu Lys Asp Pro Val Cys Tyr Leu Lys Lys Ala Phe Leu Leu Val 
        35                  40                  45              


Gln Asp Ile Met Glu Asp Xaa Met Arg Phe Arg Asp Asn Xaa Pro Asn 
    50                  55                  60                  


Ala Ile Ala Ile Val Gln Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser 
65                  70                  75                  80  


Cys Phe Xaa Lys Asp Tyr Glu Glu His Asp Lys Ala Cys Val Arg Xaa 
                85                  90                  95      


Phe Tyr Glu Xaa Pro Leu Gln Leu Leu Glu Lys Val Lys Asn Val Phe 
            100                 105                 110         


Asn Glu Xaa Lys Asn Leu Leu Asp Lys Asp Trp Asn Ile Phe Ser Lys 
        115                 120                 125             


Asn Cys Asn Asn Ser Phe Ala Glu Cys Ser Ser Gln Asp Val Val Xaa 
    130                 135                 140                 


Lys Pro Asp Cys Asn Cys Leu Tyr Pro Lys Ala Ile Pro Ser Ser Asp 
145                 150                 155                 160 


Pro Ala Ser Val Ser Pro His Gln Pro Leu Ala Pro Ser Met Ala Pro 
                165                 170                 175     


Val Ala Gly Leu Xaa Trp Glu Asp Ser Glu Gly Xaa Glu Gly Ser Ser 
            180                 185                 190         


Leu Leu Pro Gly Glu Gln Pro Leu His Xaa Val Asp Pro Gly Ser Ala 
        195                 200                 205             


Lys Gln Arg Pro Pro Arg Ser Xaa Cys Gln Ser Phe Glu Pro Pro Glu 
    210                 215                 220                 


Xaa Pro Val Val Lys Asp Ser Xaa Ile Gly Gly Ser Pro Gln Pro Arg 
225                 230                 235                 240 


Pro Ser Val Gly Ala Phe Asn Pro Gly Met Glu Asp Ile Leu Asp Ser 
                245                 250                 255     


Ala Met Gly Xaa Asn Trp Val Pro Glu Glu Ala Ser Gly Glu Ala Ser 
            260                 265                 270         


Glu Ile Pro Val Pro Gln Gly Xaa Glu Leu Ser Pro Ser 
        275                 280                 285 


<210> 7011
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 7011
Met Xaa Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Xaa Xaa Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Xaa 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Xaa Ser Cys Gln 
    50                  55                  60                  


Ile Xaa Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Xaa 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Xaa Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu 
        115                 


<210> 7012
<211> 438
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<400> 7012
Met Xaa Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Xaa Xaa Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Xaa 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Xaa Ser Cys Gln 
    50                  55                  60                  


Ile Xaa Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Xaa 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Xaa Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Xaa Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Xaa Phe Tyr Glu Xaa Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Xaa Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Asp Val Val Xaa Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                 200                 205             


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Xaa Trp Glu 
    210                 215                 220                 


Asp Ser Glu Gly Xaa Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                 230                 235                 240 


Leu His Xaa Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Xaa Cys Gln Ser Phe Glu Pro Pro Glu Xaa Pro Val Val Lys Asp Ser 
            260                 265                 270         


Xaa Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                 280                 285             


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Xaa Asn Trp Val 
    290                 295                 300                 


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                 310                 315                 320 


Xaa Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Xaa Glu 
                325                 330                 335     


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                 345                 350         


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Xaa Gly His Glu Arg Gln 
        355                 360                 365             


Ser Glu Gly Ser Phe Ser Pro Gln Leu Gln Glu Ser Val Phe His Leu 
    370                 375                 380                 


Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val Gly Gly Leu Leu 
385                 390                 395                 400 


Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro Gln Arg Ala Asp 
                405                 410                 415     


Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Xaa Gln Asp Asp Arg 
            420                 425                 430         


Gln Val Glu Leu Pro Val 
        435             


<210> 7013
<211> 554
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<400> 7013
Met Xaa Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Xaa Xaa Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Xaa 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Xaa Ser Cys Gln 
    50                  55                  60                  


Ile Xaa Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Xaa 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Xaa Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Xaa Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Xaa Phe Tyr Glu Xaa Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Xaa Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Asp Val Val Xaa Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                 200                 205             


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Xaa Trp Glu 
    210                 215                 220                 


Asp Ser Glu Gly Xaa Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                 230                 235                 240 


Leu His Xaa Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Xaa Cys Gln Ser Phe Glu Pro Pro Glu Xaa Pro Val Val Lys Asp Ser 
            260                 265                 270         


Xaa Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                 280                 285             


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Xaa Asn Trp Val 
    290                 295                 300                 


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                 310                 315                 320 


Xaa Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Xaa Glu 
                325                 330                 335     


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                 345                 350         


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Xaa Gly Xaa Ala Leu Pro 
        355                 360                 365             


Arg Val Gly Pro Val Arg Pro Xaa Gly Gln Asp Trp Asn His Xaa Pro 
    370                 375                 380                 


Gln Lys Xaa Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu Pro 
385                 390                 395                 400 


Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn Pro 
                405                 410                 415     


Ser Xaa Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser Gly 
            420                 425                 430         


Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Xaa Arg Asp 
        435                 440                 445             


Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly Ala 
    450                 455                 460                 


Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Xaa Asp Xaa Gly 
465                 470                 475                 480 


His Glu Arg Gln Ser Glu Gly Ser Phe Ser Pro Gln Leu Gln Glu Ser 
                485                 490                 495     


Val Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val 
            500                 505                 510         


Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro 
        515                 520                 525             


Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Xaa 
    530                 535                 540                 


Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
545                 550                 


<210> 7014
<211> 256
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<400> 7014
Met Xaa Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Xaa Xaa Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Xaa 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Xaa Ser Cys Gln 
    50                  55                  60                  


Ile Xaa Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Xaa 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Xaa Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Xaa Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Xaa Phe Tyr Glu Xaa Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Xaa Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Gly His Glu Arg Gln Ser Glu Gly Ser Phe Ser 
            180                 185                 190         


Pro Gln Leu Gln Glu Ser Val Phe His Leu Leu Val Pro Ser Val Ile 
        195                 200                 205             


Leu Val Leu Leu Ala Val Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg 
    210                 215                 220                 


Arg Ser His Gln Glu Pro Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Leu Xaa Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
                245                 250                 255     


<210> 7015
<211> 64
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<400> 7015
Ala Gly Ser Pro Trp Ala Leu Gly Gln Arg Pro Phe Gly Ala Gln Gly 
1               5                   10                  15      


Leu Lys Gly Pro Val Cys Val Ala Ala Xaa Ala His Ala Asp Glu Lys 
            20                  25                  30          


Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu Gly Gln His 
        35                  40                  45              


Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Xaa His Gly Gly Ile Ser 
    50                  55                  60                  


<210> 7016
<211> 306
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<400> 7016
Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Xaa Ala Trp His 
1               5                   10                  15      


Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Xaa Val Xaa Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Pro Ser Pro His Trp Xaa Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Ser Ser Ser Ile Leu Ser Xaa Asn Asn Ala Xaa Phe Gln Asn Xaa Gly 
65                  70                  75                  80  


Xaa Tyr Arg Cys Xaa Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Xaa Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg 
    130                 135                 140                 


Gly Arg Pro Leu Met Arg His Xaa Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Xaa Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Xaa Leu Val 
        195                 200                 205             


Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Xaa Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Xaa Leu Asn Leu Asp Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Xaa Ser Met Phe Phe Arg Val Val Gly Xaa Pro Ser Pro Ser Leu Cys 
    290                 295                 300                 


Pro Ala 
305     


<210> 7017
<211> 671
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<400> 7017
Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Xaa Ala Trp His 
1               5                   10                  15      


Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Xaa Val Xaa Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Pro Ser Pro His Trp Xaa Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Ser Ser Ser Ile Leu Ser Xaa Asn Asn Ala Xaa Phe Gln Asn Xaa Gly 
65                  70                  75                  80  


Xaa Tyr Arg Cys Xaa Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Xaa Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg 
    130                 135                 140                 


Gly Arg Pro Leu Met Arg His Xaa Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Xaa Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Xaa Leu Val 
        195                 200                 205             


Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Xaa Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Xaa Leu Asn Leu Asp Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Xaa Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser 
    290                 295                 300                 


Ser Glu Gln Asn Leu Ile Gln Glu Val Xaa Val Gly Glu Gly Leu Asn 
305                 310                 315                 320 


Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp 
                325                 330                 335     


Xaa Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala 
            340                 345                 350         


Asn Ala Xaa Xaa Lys Asp Xaa Tyr Arg His Xaa Phe Xaa Leu Ser Leu 
        355                 360                 365             


Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg 
    370                 375                 380                 


Asn Pro Gly Gly Trp Arg Ala Leu Xaa Phe Glu Leu Xaa Leu Arg Tyr 
385                 390                 395                 400 


Pro Pro Glu Val Ser Val Ile Trp Xaa Phe Ile Asn Gly Ser Gly Xaa 
                405                 410                 415     


Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Xaa Trp Leu 
            420                 425                 430         


Gln Cys Ser Gly His Xaa Asp Arg Cys Asp Glu Ala Gln Val Leu Gln 
        435                 440                 445             


Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His 
    450                 455                 460                 


Lys Val Xaa Val Gln Ser Leu Leu Xaa Val Glu Xaa Leu Glu His Asn 
465                 470                 475                 480 


Gln Xaa Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp 
                485                 490                 495     


Ala Phe Ile Pro Ile Ser Ala Gly Ala His Xaa His Pro Pro Asp Glu 
            500                 505                 510         


Phe Leu Phe Xaa Pro Val Val Val Ala Cys Met Ser Ile Met Ala Leu 
        515                 520                 525             


Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro 
    530                 535                 540                 


Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser 
545                 550                 555                 560 


Tyr Xaa Phe Ile Asp Pro Xaa Gln Leu Pro Tyr Asn Glu Lys Trp Glu 
                565                 570                 575     


Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Xaa Leu Gly Ala Gly Ala 
            580                 585                 590         


Phe Gly Lys Val Val Glu Ala Xaa Ala Phe Gly Leu Gly Lys Glu Asp 
        595                 600                 605             


Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Xaa Ala His Ala 
    610                 615                 620                 


Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu 
625                 630                 635                 640 


Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Xaa His Gly 
                645                 650                 655     


Gly Xaa Val Ala Ser Pro Ala Arg Val Trp Xaa Pro Met Trp Arg 
            660                 665                 670     


<210> 7018
<211> 972
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<400> 7018
Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Xaa Ala Trp His 
1               5                   10                  15      


Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Xaa Val Xaa Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Pro Ser Pro His Trp Xaa Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Ser Ser Ser Ile Leu Ser Xaa Asn Asn Ala Xaa Phe Gln Asn Xaa Gly 
65                  70                  75                  80  


Xaa Tyr Arg Cys Xaa Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Xaa Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg 
    130                 135                 140                 


Gly Arg Pro Leu Met Arg His Xaa Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Xaa Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Xaa Leu Val 
        195                 200                 205             


Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Xaa Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Xaa Leu Asn Leu Asp Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Xaa Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser 
    290                 295                 300                 


Ser Glu Gln Asn Leu Ile Gln Glu Val Xaa Val Gly Glu Gly Leu Asn 
305                 310                 315                 320 


Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp 
                325                 330                 335     


Xaa Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala 
            340                 345                 350         


Asn Ala Xaa Xaa Lys Asp Xaa Tyr Arg His Xaa Phe Xaa Leu Ser Leu 
        355                 360                 365             


Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg 
    370                 375                 380                 


Asn Pro Gly Gly Trp Arg Ala Leu Xaa Phe Glu Leu Xaa Leu Arg Tyr 
385                 390                 395                 400 


Pro Pro Glu Val Ser Val Ile Trp Xaa Phe Ile Asn Gly Ser Gly Xaa 
                405                 410                 415     


Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Xaa Trp Leu 
            420                 425                 430         


Gln Cys Ser Gly His Xaa Asp Arg Cys Asp Glu Ala Gln Val Leu Gln 
        435                 440                 445             


Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His 
    450                 455                 460                 


Lys Val Xaa Val Gln Ser Leu Leu Xaa Val Glu Xaa Leu Glu His Asn 
465                 470                 475                 480 


Gln Xaa Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp 
                485                 490                 495     


Ala Phe Ile Pro Ile Ser Ala Gly Ala His Xaa His Pro Pro Asp Glu 
            500                 505                 510         


Phe Leu Phe Xaa Pro Val Val Val Ala Cys Met Ser Ile Met Ala Leu 
        515                 520                 525             


Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro 
    530                 535                 540                 


Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser 
545                 550                 555                 560 


Tyr Xaa Phe Ile Asp Pro Xaa Gln Leu Pro Tyr Asn Glu Lys Trp Glu 
                565                 570                 575     


Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Xaa Leu Gly Ala Gly Ala 
            580                 585                 590         


Phe Gly Lys Val Val Glu Ala Xaa Ala Phe Gly Leu Gly Lys Glu Asp 
        595                 600                 605             


Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Xaa Ala His Ala 
    610                 615                 620                 


Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu 
625                 630                 635                 640 


Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Xaa His Gly 
                645                 650                 655     


Gly Pro Val Leu Val Ile Xaa Glu Tyr Cys Cys Tyr Gly Asp Leu Leu 
            660                 665                 670         


Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser 
        675                 680                 685             


Pro Gly Gln Asp Pro Glu Gly Gly Val Asp Tyr Lys Asn Ile His Leu 
    690                 695                 700                 


Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val 
705                 710                 715                 720 


Asp Xaa Tyr Val Glu Met Arg Pro Val Ser Xaa Ser Ser Asn Asp Ser 
                725                 730                 735     


Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu 
            740                 745                 750         


Arg Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe 
        755                 760                 765             


Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val 
    770                 775                 780                 


Leu Leu Xaa Asn Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala 
785                 790                 795                 800 


Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg 
                805                 810                 815     


Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr 
            820                 825                 830         


Xaa Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile 
        835                 840                 845             


Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys 
    850                 855                 860                 


Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe 
865                 870                 875                 880 


Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu 
                885                 890                 895     


Pro Xaa His Arg Pro Xaa Phe Gln Gln Ile Cys Ser Phe Leu Gln Glu 
            900                 905                 910         


Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp Tyr Xaa Asn Leu Pro Ser 
        915                 920                 925             


Ser Ser Arg Ser Gly Gly Ser Gly Ser Ser Ser Ser Glu Leu Glu Glu 
    930                 935                 940                 


Glu Ser Ser Ser Glu His Leu Xaa Cys Cys Glu Gln Gly Asp Ile Ala 
945                 950                 955                 960 


Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe Cys 
                965                 970         


<210> 7019
<211> 49
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<400> 7019
Met Arg His Xaa Asn Tyr Ser Phe Ser Pro Trp His Gly Phe Xaa Ile 
1               5                   10                  15      


His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln Cys Ser Ala Leu 
            20                  25                  30          


Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg Leu Lys Val Gln 
        35                  40                  45              


Lys 
    


<210> 7020
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<400> 7020
Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Xaa Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Xaa Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Xaa Ala Ala Glu Met Asn Glu Xaa Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Xaa Cys Leu Gln Xaa Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Xaa Lys Leu Lys Gly Pro Leu Xaa Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Xaa Pro Glu Xaa Ser 
            100                 105                 110         


Cys Ala Xaa Gln Ile Ile Xaa Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210> 7021
<211> 238
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<400> 7021
Met Leu Leu Leu Val Xaa Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Xaa Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Xaa Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Xaa Xaa Phe Ser Lys Cys Phe Leu Xaa Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Xaa Phe Arg Glu Ile Cys Leu His Glu Gly Val Xaa Phe Glu Val 
                85                  90                  95      


His Val Asn Xaa Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Xaa Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Xaa Trp Ala Arg Gly Pro Xaa Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Xaa His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Xaa Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Xaa Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Xaa Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Xaa Val Arg Cys Asn Xaa Xaa His Cys Leu Val Arg Trp Lys 
225                 230                 235             


<210> 7022
<211> 285
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<400> 7022
Met Leu Leu Leu Val Xaa Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Xaa Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Xaa Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Xaa Xaa Phe Ser Lys Cys Phe Leu Xaa Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Xaa Phe Arg Glu Ile Cys Leu His Glu Gly Val Xaa Phe Glu Val 
                85                  90                  95      


His Val Asn Xaa Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Xaa Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Xaa Trp Ala Arg Gly Pro Xaa Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Xaa His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Xaa Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Xaa Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Xaa Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Xaa Val Arg Cys Asn Xaa Xaa His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Xaa Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Xaa Gln Pro Gly Xaa Glu Asn Leu Leu Val Leu 
            260                 265                 270         


Xaa Xaa Gly Xaa Ser Ala Leu Cys Xaa Phe Met Cys Ser 
        275                 280                 285 


<210> 7023
<211> 333
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<400> 7023
Met Leu Leu Leu Val Xaa Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Xaa Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Xaa Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Xaa Xaa Phe Ser Lys Cys Phe Leu Xaa Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Xaa Phe Arg Glu Ile Cys Leu His Glu Gly Val Xaa Phe Glu Val 
                85                  90                  95      


His Val Asn Xaa Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Xaa Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Xaa Trp Ala Arg Gly Pro Xaa Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Xaa His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Xaa Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Xaa Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Xaa Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Xaa Val Arg Cys Asn Xaa Xaa His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Xaa Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Xaa Gln Pro Gly Xaa Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Leu Gly Tyr 
305                 310                 315                 320 


Ser Gly Cys Ser Arg Gln Phe His Arg Ser Lys Xaa Asn 
                325                 330             


<210> 7024
<211> 377
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<400> 7024
Met Leu Leu Leu Val Xaa Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Xaa Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Xaa Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Xaa Xaa Phe Ser Lys Cys Phe Leu Xaa Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Xaa Phe Arg Glu Ile Cys Leu His Glu Gly Val Xaa Phe Glu Val 
                85                  90                  95      


His Val Asn Xaa Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Xaa Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Xaa Trp Ala Arg Gly Pro Xaa Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Xaa His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Xaa Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Xaa Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Xaa Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Xaa Val Arg Cys Asn Xaa Xaa His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Xaa Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Xaa Gln Pro Gly Xaa Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Asp His Leu Gly Gly 
305                 310                 315                 320 


Ile His Pro Arg Gly Arg Glu Arg Leu Pro Arg Arg Gly Leu Asp Arg 
                325                 330                 335     


Glu Gly Asn Tyr Leu Arg Pro Arg Gly Cys Arg Asn Gly Met Asp Ile 
            340                 345                 350         


Ser Ala Ser Ala Xaa Arg Gly Asn Cys Phe Leu Asp Asp Ala Val Asn 
        355                 360                 365             


Leu Tyr Ile Ile Phe Tyr Val Phe Ile 
    370                 375         


<210> 7025
<211> 400
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<400> 7025
Met Leu Leu Leu Val Xaa Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Xaa Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Xaa Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Xaa Xaa Phe Ser Lys Cys Phe Leu Xaa Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Xaa Phe Arg Glu Ile Cys Leu His Glu Gly Val Xaa Phe Glu Val 
                85                  90                  95      


His Val Asn Xaa Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Xaa Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Xaa Trp Ala Arg Gly Pro Xaa Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Xaa His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Xaa Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Xaa Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Xaa Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Xaa Val Arg Cys Asn Xaa Xaa His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Xaa Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Xaa Gln Pro Gly Xaa Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly 
305                 310                 315                 320 


Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Xaa Leu 
                325                 330                 335     


Val Cys Gly Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu Arg Ile 
            340                 345                 350         


Gln Arg Leu Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu Asn Asp 
        355                 360                 365             


Asn His Glu Val Glu Asp Glu Ile Ile Trp Glu Glu Phe Xaa Pro Glu 
    370                 375                 380                 


Glu Gly Lys Gly Tyr Arg Glu Glu Val Leu Xaa Val Lys Glu Ile Xaa 
385                 390                 395                 400 


<210> 7026
<211> 410
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<400> 7026
Met Leu Leu Leu Val Xaa Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Xaa Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Xaa Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Xaa Xaa Phe Ser Lys Cys Phe Leu Xaa Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Xaa Phe Arg Glu Ile Cys Leu His Glu Gly Val Xaa Phe Glu Val 
                85                  90                  95      


His Val Asn Xaa Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Xaa Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Xaa Trp Ala Arg Gly Pro Xaa Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Xaa His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Xaa Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Xaa Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Xaa Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Xaa Val Arg Cys Asn Xaa Xaa His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Xaa Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Xaa Gln Pro Gly Xaa Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly 
305                 310                 315                 320 


Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Xaa Leu 
                325                 330                 335     


Val Cys Gly Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu Arg Ile 
            340                 345                 350         


Gln Arg Leu Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu Asn Asp 
        355                 360                 365             


Asn His Glu Val Glu Asp Glu Met Gly Pro Gln Arg His His Arg Cys 
    370                 375                 380                 


Gly Trp Asn Leu Tyr Pro Xaa Pro Gly Pro Ser Pro Gly Ser Gly Ser 
385                 390                 395                 400 


Ser Pro Arg Leu Gly Ser Glu Ser Ser Leu 
                405                 410 


<210> 7027
<211> 434
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<400> 7027
Met Leu Leu Leu Val Xaa Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Xaa Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Xaa Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Xaa Xaa Phe Ser Lys Cys Phe Leu Xaa Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Xaa Phe Arg Glu Ile Cys Leu His Glu Gly Val Xaa Phe Glu Val 
                85                  90                  95      


His Val Asn Xaa Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Xaa Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Xaa Trp Ala Arg Gly Pro Xaa Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Xaa His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Xaa Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Xaa Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Xaa Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Xaa Val Arg Cys Asn Xaa Xaa His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Xaa Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Xaa Gln Pro Gly Xaa Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser His Ser Val 
305                 310                 315                 320 


Xaa Gln Ala Gly Val Gln Trp His Asn Leu Gly Ser Leu Gln Pro Pro 
                325                 330                 335     


Ser Pro Arg Leu Lys Arg Phe Ser Cys Leu Arg Leu Pro Gly Ser Asp 
            340                 345                 350         


Asp Gly Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly 
        355                 360                 365             


Xaa Leu Val Cys Gly Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu 
    370                 375                 380                 


Arg Ile Gln Arg Leu Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu 
385                 390                 395                 400 


Asn Asp Asn His Glu Val Glu Asp Glu Ile Ile Trp Glu Glu Phe Xaa 
                405                 410                 415     


Pro Glu Glu Gly Lys Gly Tyr Arg Glu Glu Val Leu Xaa Val Lys Glu 
            420                 425                 430         


Ile Xaa 
        


<210> 7028
<211> 233
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<400> 7028
Met Leu Leu Leu Val Xaa Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Xaa Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Xaa Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Xaa Xaa Phe Ser Lys Cys Phe Leu Xaa Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Xaa Phe Arg Glu Ile Cys Leu His Glu Gly Val Xaa Phe Glu Val 
                85                  90                  95      


His Val Asn Xaa Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Xaa Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Xaa Trp Ala Arg Gly Pro Xaa Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Xaa His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Xaa Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Xaa Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Xaa Lys Lys Ile Gly Ser Leu Gly Tyr Ser Gly Cys Ser 
    210                 215                 220                 


Arg Gln Phe His Arg Ser Lys Xaa Asn 
225                 230             


<210> 7029
<211> 90
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<400> 7029
Met Leu Leu Leu Val Xaa Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Xaa Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Xaa Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Xaa Xaa Phe Ser Lys Cys Phe Leu Xaa Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Met Glu Phe Pro Ser Cys Cys 
65                  70                  75                  80  


Pro Asp Arg Xaa Ile Ala His Gln Pro Ala 
                85                  90  


<210> 7030
<211> 267
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<400> 7030
Met Asn Cys Xaa Trp Ala Arg Gly Pro Xaa Ala Pro Arg Asp Val Gln 
1               5                   10                  15      


Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg Arg Glu Ile Arg Cys 
            20                  25                  30          


Pro Tyr Tyr Ile Gln Asp Ser Gly Xaa His Val Gly Cys His Leu Asp 
        35                  40                  45              


Asn Leu Ser Gly Leu Xaa Ser Arg Asn Tyr Phe Leu Val Asn Gly Xaa 
    50                  55                  60                  


Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser Leu Leu Asp Xaa Lys 
65                  70                  75                  80  


Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val Xaa Val Arg Cys Asn 
                85                  90                  95      


Xaa Xaa His Cys Leu Val Arg Trp Lys Gln Pro Arg Xaa Tyr Gln Lys 
            100                 105                 110         


Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp Val His Arg Lys Asn 
        115                 120                 125             


Xaa Gln Pro Gly Xaa Glu Asn Leu Leu Ile Asn Val Ser Gly Asp Leu 
    130                 135                 140                 


Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro Arg Ala Lys His Ser 
145                 150                 155                 160 


Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu Asn Trp Ser Ser Trp 
                165                 170                 175     


Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly Asn Leu Gly Ser Val 
            180                 185                 190         


Tyr Ile Tyr Val Leu Leu Ile Val Gly Xaa Leu Val Cys Gly Ile Val 
        195                 200                 205             


Leu Gly Phe Leu Phe Lys Arg Phe Leu Arg Ile Gln Arg Leu Phe Pro 
    210                 215                 220                 


Pro Val Pro Gln Ile Lys Asp Lys Leu Asn Asp Asn His Glu Val Glu 
225                 230                 235                 240 


Asp Glu Ile Ile Trp Glu Glu Phe Xaa Pro Glu Glu Gly Lys Gly Tyr 
                245                 250                 255     


Arg Glu Glu Val Leu Xaa Val Lys Glu Ile Xaa 
            260                 265         


<210> 7031
<211> 229
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<400> 7031
Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
1               5                   10                  15      


Val Ile Pro Cys Gln Ser Phe Val Val Xaa Asp Val Asp Tyr Phe Ser 
            20                  25                  30          


Phe Gln Pro Asp Arg Pro Leu Gly Xaa Arg Leu Xaa Val Xaa Leu Xaa 
        35                  40                  45              


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Xaa Asp 
    50                  55                  60                  


Gln Asp His Phe Leu Leu Xaa Trp Ser Val Ala Leu Gly Ser Pro Gln 
65                  70                  75                  80  


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
                85                  90                  95      


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Xaa 
            100                 105                 110         


Ser Gln Ala Xaa Leu Gly Pro Glu His Leu Met Pro Ser Ser Xaa Tyr 
        115                 120                 125             


Val Ala Arg Val Arg Xaa Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
    130                 135                 140                 


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
145                 150                 155                 160 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
                165                 170                 175     


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
            180                 185                 190         


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
        195                 200                 205             


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Xaa Arg His 
    210                 215                 220                 


His Cys Gln Ile Pro 
225                 


<210> 7032
<211> 889
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<400> 7032
Met Val Leu Ala Gln Gly Leu Leu Ser Met Ala Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Xaa Ile Pro Leu Gln Xaa 
            20                  25                  30          


Leu Arg Cys Tyr Asn Asp Tyr Xaa Ser His Ile Xaa Cys Arg Trp Ala 
        35                  40                  45              


Asp Xaa Gln Asp Ala Gln Arg Leu Val Asn Val Xaa Leu Ile Arg Arg 
    50                  55                  60                  


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
65                  70                  75                  80  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
                85                  90                  95      


Val Ile Pro Cys Gln Ser Phe Val Val Xaa Asp Val Asp Tyr Phe Ser 
            100                 105                 110         


Phe Gln Pro Asp Arg Pro Leu Gly Xaa Arg Leu Xaa Val Xaa Leu Xaa 
        115                 120                 125             


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Xaa Asp 
    130                 135                 140                 


Gln Asp His Phe Leu Leu Xaa Trp Ser Val Ala Leu Gly Ser Pro Gln 
145                 150                 155                 160 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
                165                 170                 175     


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Xaa 
            180                 185                 190         


Ser Gln Ala Xaa Leu Gly Pro Glu His Leu Met Pro Ser Ser Xaa Tyr 
        195                 200                 205             


Val Ala Arg Val Arg Xaa Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
    210                 215                 220                 


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
225                 230                 235                 240 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
                245                 250                 255     


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
            260                 265                 270         


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
        275                 280                 285             


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Xaa Arg His 
    290                 295                 300                 


His Cys Gln Ile Pro Val Pro Asp Pro Ala Xaa His Gly Gln Tyr Ile 
305                 310                 315                 320 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
                325                 330                 335     


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Xaa Lys Asp Gly Asp 
            340                 345                 350         


Ser Tyr Ser Leu Arg Trp Glu Xaa Met Lys Met Arg Tyr Glu His Ile 
        355                 360                 365             


Asp His Xaa Phe Glu Ile Gln Tyr Arg Lys Asp Xaa Ala Xaa Trp Lys 
    370                 375                 380                 


Asp Ser Lys Xaa Glu Xaa Leu Gln Asn Ala His Ser Met Ala Leu Pro 
385                 390                 395                 400 


Ala Leu Glu Pro Ser Xaa Arg Tyr Trp Ala Arg Val Arg Val Arg Xaa 
                405                 410                 415     


Ser Arg Xaa Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
            420                 425                 430         


Ser Trp Asp Xaa Glu Ser Val Leu Pro Met Trp Val Leu Ala Leu Ile 
        435                 440                 445             


Val Ile Phe Leu Xaa Ile Ala Val Leu Leu Ala Leu Arg Phe Cys Gly 
    450                 455                 460                 


Ile Tyr Gly Tyr Arg Leu Arg Arg Lys Trp Glu Glu Lys Ile Pro Asn 
465                 470                 475                 480 


Pro Ser Lys Ser His Leu Phe Gln Asn Gly Ser Ala Glu Leu Trp Pro 
                485                 490                 495     


Pro Gly Ser Met Ser Ala Phe Xaa Ser Gly Ser Pro Pro His Gln Gly 
            500                 505                 510         


Pro Trp Gly Ser Arg Phe Pro Glu Leu Glu Gly Val Phe Pro Val Gly 
        515                 520                 525             


Phe Gly Asp Ser Glu Val Ser Pro Leu Xaa Ile Glu Asp Pro Lys His 
    530                 535                 540                 


Val Cys Asp Pro Pro Ser Gly Pro Asp Xaa Xaa Pro Ala Ala Ser Asp 
545                 550                 555                 560 


Leu Pro Xaa Glu Gln Pro Pro Ser Pro Gln Pro Gly Pro Pro Ala Ala 
                565                 570                 575     


Ser His Xaa Pro Glu Lys Gln Ala Ser Ser Phe Asp Phe Asn Gly Pro 
            580                 585                 590         


Tyr Leu Gly Pro Pro His Ser Arg Ser Leu Pro Asp Ile Leu Gly Gln 
        595                 600                 605             


Pro Glu Pro Pro Gln Glu Gly Gly Ser Gln Lys Ser Pro Pro Pro Gly 
    610                 615                 620                 


Ser Leu Glu Tyr Leu Cys Leu Pro Ala Gly Gly Gln Val Gln Leu Val 
625                 630                 635                 640 


Pro Leu Ala Gln Ala Met Gly Pro Gly Gln Ala Val Glu Val Glu Arg 
                645                 650                 655     


Arg Pro Ser Gln Gly Ala Ala Gly Ser Pro Ser Leu Glu Ser Gly Gly 
            660                 665                 670         


Gly Pro Ala Pro Pro Ala Leu Gly Pro Arg Val Gly Gly Gln Asp Gln 
        675                 680                 685             


Lys Asp Ser Pro Val Ala Ile Pro Met Ser Ser Gly Asp Xaa Glu Asp 
    690                 695                 700                 


Pro Gly Val Ala Ser Gly Tyr Val Ser Ser Ala Asp Leu Val Phe Xaa 
705                 710                 715                 720 


Pro Asn Ser Gly Ala Ser Ser Val Ser Leu Val Pro Ser Leu Gly Leu 
                725                 730                 735     


Pro Ser Asp Gln Xaa Pro Ser Leu Cys Pro Gly Leu Ala Ser Gly Pro 
            740                 745                 750         


Pro Gly Ala Pro Gly Pro Val Lys Ser Gly Phe Glu Gly Tyr Val Glu 
        755                 760                 765             


Leu Pro Pro Ile Glu Gly Arg Ser Pro Arg Ser Pro Arg Asn Asn Pro 
    770                 775                 780                 


Val Pro Pro Glu Ala Lys Ser Pro Val Leu Asn Pro Gly Glu Arg Pro 
785                 790                 795                 800 


Ala Asp Val Ser Pro Xaa Ser Pro Gln Pro Glu Gly Leu Leu Val Leu 
                805                 810                 815     


Gln Gln Val Gly Asp Tyr Cys Phe Leu Pro Gly Leu Gly Pro Gly Pro 
            820                 825                 830         


Leu Ser Leu Arg Ser Lys Pro Ser Ser Pro Gly Pro Gly Pro Glu Ile 
        835                 840                 845             


Lys Asn Leu Asp Gln Ala Phe Gln Val Lys Lys Pro Pro Gly Gln Ala 
    850                 855                 860                 


Val Pro Gln Val Pro Val Ile Gln Leu Phe Lys Ala Leu Val Val Ser 
865                 870                 875                 880 


Val Met Ser Val Gly Pro Pro Val Pro 
                885                 


<210> 7033
<211> 897
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<400> 7033
Met Val Leu Ala Gln Gly Leu Leu Ser Met Ala Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Xaa Ile Pro Leu Gln Xaa 
            20                  25                  30          


Leu Arg Cys Tyr Asn Asp Tyr Xaa Ser His Ile Xaa Cys Arg Trp Ala 
        35                  40                  45              


Asp Xaa Gln Asp Ala Gln Arg Leu Val Asn Val Xaa Leu Ile Arg Arg 
    50                  55                  60                  


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
65                  70                  75                  80  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
                85                  90                  95      


Val Ile Pro Cys Gln Ser Phe Val Val Xaa Asp Val Asp Tyr Phe Ser 
            100                 105                 110         


Phe Gln Pro Asp Arg Pro Leu Gly Xaa Arg Leu Xaa Val Xaa Leu Xaa 
        115                 120                 125             


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Xaa Asp 
    130                 135                 140                 


Gln Asp His Phe Leu Leu Xaa Trp Ser Val Ala Leu Gly Ser Pro Gln 
145                 150                 155                 160 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
                165                 170                 175     


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Xaa 
            180                 185                 190         


Ser Gln Ala Xaa Leu Gly Pro Glu His Leu Met Pro Ser Ser Xaa Tyr 
        195                 200                 205             


Val Ala Arg Val Arg Xaa Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
    210                 215                 220                 


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
225                 230                 235                 240 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
                245                 250                 255     


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
            260                 265                 270         


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
        275                 280                 285             


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Xaa Arg His 
    290                 295                 300                 


His Cys Gln Ile Pro Val Pro Asp Pro Ala Xaa His Gly Gln Tyr Ile 
305                 310                 315                 320 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
                325                 330                 335     


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Xaa Lys Asp Gly Asp 
            340                 345                 350         


Ser Tyr Ser Leu Arg Trp Glu Xaa Met Lys Met Arg Tyr Glu His Ile 
        355                 360                 365             


Asp His Xaa Phe Glu Ile Gln Tyr Arg Lys Asp Xaa Ala Xaa Trp Lys 
    370                 375                 380                 


Asp Ser Lys Xaa Glu Xaa Leu Gln Asn Ala His Ser Met Ala Leu Pro 
385                 390                 395                 400 


Ala Leu Glu Pro Ser Xaa Arg Tyr Trp Ala Arg Val Arg Val Arg Xaa 
                405                 410                 415     


Ser Arg Xaa Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
            420                 425                 430         


Ser Trp Asp Xaa Glu Ser Val Leu Pro Met Trp Val Leu Ala Leu Ile 
        435                 440                 445             


Val Ile Phe Leu Xaa Ile Ala Val Leu Leu Ala Leu Arg Phe Cys Gly 
    450                 455                 460                 


Ile Tyr Gly Tyr Arg Leu Arg Arg Lys Trp Glu Glu Lys Ile Pro Asn 
465                 470                 475                 480 


Pro Ser Lys Ser His Leu Phe Gln Asn Gly Ser Ala Glu Leu Trp Pro 
                485                 490                 495     


Pro Gly Ser Met Ser Ala Phe Xaa Ser Gly Ser Pro Pro His Gln Gly 
            500                 505                 510         


Pro Trp Gly Ser Arg Phe Pro Glu Leu Glu Gly Val Phe Pro Val Gly 
        515                 520                 525             


Phe Gly Asp Ser Glu Val Ser Pro Leu Xaa Ile Glu Asp Pro Lys His 
    530                 535                 540                 


Val Cys Asp Pro Pro Ser Gly Pro Asp Xaa Xaa Pro Ala Ala Ser Asp 
545                 550                 555                 560 


Leu Pro Xaa Glu Gln Pro Pro Ser Pro Gln Pro Gly Pro Pro Ala Ala 
                565                 570                 575     


Ser His Xaa Pro Glu Lys Gln Ala Ser Ser Phe Asp Phe Asn Gly Pro 
            580                 585                 590         


Tyr Leu Gly Pro Pro His Ser Arg Ser Leu Pro Asp Ile Leu Gly Gln 
        595                 600                 605             


Pro Glu Pro Pro Gln Glu Gly Gly Ser Gln Lys Ser Pro Pro Pro Gly 
    610                 615                 620                 


Ser Leu Glu Tyr Leu Cys Leu Pro Ala Gly Gly Gln Val Gln Leu Val 
625                 630                 635                 640 


Pro Leu Ala Gln Ala Met Gly Pro Gly Gln Ala Val Glu Val Glu Arg 
                645                 650                 655     


Arg Pro Ser Gln Gly Ala Ala Gly Ser Pro Ser Leu Glu Ser Gly Gly 
            660                 665                 670         


Gly Pro Ala Pro Pro Ala Leu Gly Pro Arg Val Gly Gly Gln Asp Gln 
        675                 680                 685             


Lys Asp Ser Pro Val Ala Ile Pro Met Ser Ser Gly Asp Xaa Glu Asp 
    690                 695                 700                 


Pro Gly Val Ala Ser Gly Tyr Val Ser Ser Ala Asp Leu Val Phe Xaa 
705                 710                 715                 720 


Pro Asn Ser Gly Ala Ser Ser Val Ser Leu Val Pro Ser Leu Gly Leu 
                725                 730                 735     


Pro Ser Asp Gln Xaa Pro Ser Leu Cys Pro Gly Leu Ala Ser Gly Pro 
            740                 745                 750         


Pro Gly Ala Pro Gly Pro Val Lys Ser Gly Phe Glu Gly Tyr Val Glu 
        755                 760                 765             


Leu Pro Pro Ile Glu Gly Arg Ser Pro Arg Ser Pro Arg Asn Asn Pro 
    770                 775                 780                 


Val Pro Pro Glu Ala Lys Ser Pro Val Leu Asn Pro Gly Glu Arg Pro 
785                 790                 795                 800 


Ala Asp Val Ser Pro Xaa Ser Pro Gln Pro Glu Gly Leu Leu Val Leu 
                805                 810                 815     


Gln Gln Val Gly Asp Tyr Cys Phe Leu Pro Gly Leu Gly Pro Gly Pro 
            820                 825                 830         


Leu Ser Leu Arg Ser Lys Pro Ser Ser Pro Gly Pro Gly Pro Glu Ile 
        835                 840                 845             


Lys Asn Leu Asp Gln Ala Phe Gln Val Lys Lys Pro Pro Gly Gln Ala 
    850                 855                 860                 


Val Pro Gln Val Pro Val Ile Gln Leu Phe Lys Ala Leu Lys Gln Gln 
865                 870                 875                 880 


Asp Tyr Leu Ser Leu Pro Pro Trp Glu Val Asn Lys Pro Gly Glu Val 
                885                 890                 895     


Cys 
    


<210> 7034
<211> 903
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<400> 7034
Met Val Leu Ala Gln Gly Leu Leu Ser Met Ala Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Xaa Ile Pro Leu Gln Xaa 
            20                  25                  30          


Leu Arg Cys Tyr Asn Asp Tyr Xaa Ser His Ile Xaa Cys Arg Trp Ala 
        35                  40                  45              


Asp Xaa Gln Asp Ala Gln Arg Leu Val Asn Val Xaa Leu Ile Arg Arg 
    50                  55                  60                  


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
65                  70                  75                  80  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
                85                  90                  95      


Val Ile Pro Cys Gln Ser Phe Val Val Xaa Asp Val Asp Tyr Phe Ser 
            100                 105                 110         


Phe Gln Pro Asp Arg Pro Leu Gly Xaa Arg Leu Xaa Val Xaa Leu Xaa 
        115                 120                 125             


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Xaa Asp 
    130                 135                 140                 


Gln Asp His Phe Leu Leu Xaa Trp Ser Val Ala Leu Gly Ser Pro Gln 
145                 150                 155                 160 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
                165                 170                 175     


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Xaa 
            180                 185                 190         


Ser Gln Ala Xaa Leu Gly Pro Glu His Leu Met Pro Ser Ser Xaa Tyr 
        195                 200                 205             


Val Ala Arg Val Arg Xaa Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
    210                 215                 220                 


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
225                 230                 235                 240 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
                245                 250                 255     


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
            260                 265                 270         


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Ser Ala Val 
        275                 280                 285             


Leu Leu Arg Glu Glu Glu Cys Ser Pro Val Leu Arg Glu Gly Leu Gly 
    290                 295                 300                 


Ser Leu His Xaa Arg His His Cys Gln Ile Pro Val Pro Asp Pro Ala 
305                 310                 315                 320 


Xaa His Gly Gln Tyr Ile Val Ser Val Gln Pro Arg Arg Ala Glu Lys 
                325                 330                 335     


His Ile Lys Ser Ser Val Asn Ile Gln Met Ala Pro Pro Ser Leu Asn 
            340                 345                 350         


Val Xaa Lys Asp Gly Asp Ser Tyr Ser Leu Arg Trp Glu Xaa Met Lys 
        355                 360                 365             


Met Arg Tyr Glu His Ile Asp His Xaa Phe Glu Ile Gln Tyr Arg Lys 
    370                 375                 380                 


Asp Xaa Ala Xaa Trp Lys Asp Ser Lys Xaa Glu Xaa Leu Gln Asn Ala 
385                 390                 395                 400 


His Ser Met Ala Leu Pro Ala Leu Glu Pro Ser Xaa Arg Tyr Trp Ala 
                405                 410                 415     


Arg Val Arg Val Arg Xaa Ser Arg Xaa Gly Tyr Asn Gly Ile Trp Ser 
            420                 425                 430         


Glu Trp Ser Glu Ala Arg Ser Trp Asp Xaa Glu Ser Val Leu Pro Met 
        435                 440                 445             


Trp Val Leu Ala Leu Ile Val Ile Phe Leu Xaa Ile Ala Val Leu Leu 
    450                 455                 460                 


Ala Leu Arg Phe Cys Gly Ile Tyr Gly Tyr Arg Leu Arg Arg Lys Trp 
465                 470                 475                 480 


Glu Glu Lys Ile Pro Asn Pro Ser Lys Ser His Leu Phe Gln Asn Gly 
                485                 490                 495     


Ser Ala Glu Leu Trp Pro Pro Gly Ser Met Ser Ala Phe Xaa Ser Gly 
            500                 505                 510         


Ser Pro Pro His Gln Gly Pro Trp Gly Ser Arg Phe Pro Glu Leu Glu 
        515                 520                 525             


Gly Val Phe Pro Val Gly Phe Gly Asp Ser Glu Val Ser Pro Leu Xaa 
    530                 535                 540                 


Ile Glu Asp Pro Lys His Val Cys Asp Pro Pro Ser Gly Pro Asp Xaa 
545                 550                 555                 560 


Xaa Pro Ala Ala Ser Asp Leu Pro Xaa Glu Gln Pro Pro Ser Pro Gln 
                565                 570                 575     


Pro Gly Pro Pro Ala Ala Ser His Xaa Pro Glu Lys Gln Ala Ser Ser 
            580                 585                 590         


Phe Asp Phe Asn Gly Pro Tyr Leu Gly Pro Pro His Ser Arg Ser Leu 
        595                 600                 605             


Pro Asp Ile Leu Gly Gln Pro Glu Pro Pro Gln Glu Gly Gly Ser Gln 
    610                 615                 620                 


Lys Ser Pro Pro Pro Gly Ser Leu Glu Tyr Leu Cys Leu Pro Ala Gly 
625                 630                 635                 640 


Gly Gln Val Gln Leu Val Pro Leu Ala Gln Ala Met Gly Pro Gly Gln 
                645                 650                 655     


Ala Val Glu Val Glu Arg Arg Pro Ser Gln Gly Ala Ala Gly Ser Pro 
            660                 665                 670         


Ser Leu Glu Ser Gly Gly Gly Pro Ala Pro Pro Ala Leu Gly Pro Arg 
        675                 680                 685             


Val Gly Gly Gln Asp Gln Lys Asp Ser Pro Val Ala Ile Pro Met Ser 
    690                 695                 700                 


Ser Gly Asp Xaa Glu Asp Pro Gly Val Ala Ser Gly Tyr Val Ser Ser 
705                 710                 715                 720 


Ala Asp Leu Val Phe Xaa Pro Asn Ser Gly Ala Ser Ser Val Ser Leu 
                725                 730                 735     


Val Pro Ser Leu Gly Leu Pro Ser Asp Gln Xaa Pro Ser Leu Cys Pro 
            740                 745                 750         


Gly Leu Ala Ser Gly Pro Pro Gly Ala Pro Gly Pro Val Lys Ser Gly 
        755                 760                 765             


Phe Glu Gly Tyr Val Glu Leu Pro Pro Ile Glu Gly Arg Ser Pro Arg 
    770                 775                 780                 


Ser Pro Arg Asn Asn Pro Val Pro Pro Glu Ala Lys Ser Pro Val Leu 
785                 790                 795                 800 


Asn Pro Gly Glu Arg Pro Ala Asp Val Ser Pro Xaa Ser Pro Gln Pro 
                805                 810                 815     


Glu Gly Leu Leu Val Leu Gln Gln Val Gly Asp Tyr Cys Phe Leu Pro 
            820                 825                 830         


Gly Leu Gly Pro Gly Pro Leu Ser Leu Arg Ser Lys Pro Ser Ser Pro 
        835                 840                 845             


Gly Pro Gly Pro Glu Ile Lys Asn Leu Asp Gln Ala Phe Gln Val Lys 
    850                 855                 860                 


Lys Pro Pro Gly Gln Ala Val Pro Gln Val Pro Val Ile Gln Leu Phe 
865                 870                 875                 880 


Lys Ala Leu Lys Gln Gln Asp Tyr Leu Ser Leu Pro Pro Trp Glu Val 
                885                 890                 895     


Asn Lys Pro Gly Glu Val Cys 
            900             


<210> 7035
<211> 155
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 7035
Met Ala Gly Pro Ala Xaa Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Xaa Val Gln Glu Ala Xaa Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln 
65                  70                  75                  80  


Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Xaa 
                85                  90                  95      


Leu Asp Xaa Leu Gln Leu Asp Val Ala Asp Phe Ala Xaa Xaa Ile Trp 
            100                 105                 110         


Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Xaa Gln 
        115                 120                 125             


Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly 
    130                 135                 140                 


Val Leu Val Ala Ser His Leu Gln Ser Phe Leu 
145                 150                 155 


<210> 7036
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<400> 7036
Met Ala Gly Pro Ala Xaa Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Xaa Val Gln Glu Ala Xaa Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Cys Ala Xaa Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 
65                  70                  75                  80  


Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 
                85                  90                  95      


Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 
            100                 105                 110         


Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 
        115                 120                 125             


Leu Gly Pro Xaa Leu Asp Xaa Leu Gln Leu Asp Val Ala Asp Phe Ala 
    130                 135                 140                 


Xaa Xaa Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 
145                 150                 155                 160 


Gln Pro Xaa Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 
                165                 170                 175     


Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 
            180                 185                 190         


Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 


<210> 7037
<211> 171
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 7037
Met Ala Gly Pro Ala Xaa Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Xaa Val Gln Glu Ala Xaa Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe 
65                  70                  75                  80  


Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu 
                85                  90                  95      


Gly Pro Xaa Leu Asp Xaa Leu Gln Leu Asp Val Ala Asp Phe Ala Xaa 
            100                 105                 110         


Xaa Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln 
        115                 120                 125             


Pro Xaa Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg 
    130                 135                 140                 


Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val 
145                 150                 155                 160 


Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170     


<210> 7038
<211> 207
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 7038
Met Ala Gly Pro Ala Xaa Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Xaa Val Gln Glu Ala Xaa Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Cys Ala Xaa Tyr Lys Leu Cys His Pro Glu Glu Leu 
65                  70                  75                  80  


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
                85                  90                  95      


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
            100                 105                 110         


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
        115                 120                 125             


Ser Pro Glu Leu Gly Pro Xaa Leu Asp Xaa Leu Gln Leu Asp Val Ala 
    130                 135                 140                 


Asp Phe Ala Xaa Xaa Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
145                 150                 155                 160 


Pro Ala Leu Gln Pro Xaa Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
                165                 170                 175     


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
            180                 185                 190         


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 205         


<210> 7039
<211> 57
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<400> 7039
Met Ala Gly Pro Ala Xaa Gln Ser Pro Met Lys Leu Met Val Cys His 
1               5                   10                  15      


Leu Gln Ala Val Pro Pro Arg Gly Ala Gly Ala Ala Arg Xaa Leu Ser 
            20                  25                  30          


Gly His Pro Leu Gly Ser Pro Glu Gln Leu Pro Gln Pro Gly Pro Ala 
        35                  40                  45              


Ala Gly Arg Leu Leu Glu Pro Xaa Pro 
    50                  55          


<210> 7040
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<400> 7040
Met Ser Pro Glu Pro Ala Leu Ser Pro Ala Leu Gln Leu Leu Leu Trp 
1               5                   10                  15      


His Ser Ala Leu Trp Xaa Val Gln Glu Ala Xaa Pro Leu Gly Pro Ala 
            20                  25                  30          


Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Arg 
        35                  40                  45              


Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Ala Gly Cys 
    50                  55                  60                  


Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln 
65                  70                  75                  80  


Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Xaa Leu Asp Xaa Leu 
                85                  90                  95      


Gln Leu Asp Val Ala Asp Phe Ala Xaa Xaa Ile Trp Gln Gln Met Glu 
            100                 105                 110         


Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Xaa Gln Gly Ala Met Pro 
        115                 120                 125             


Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala 
    130                 135                 140                 


Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His 
145                 150                 155                 160 


Leu Ala Gln Pro 
                


<210> 7041
<211> 200
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<400> 7041
Met Ser Pro Glu Pro Ala Leu Ser Pro Ala Leu Gln Leu Leu Leu Trp 
1               5                   10                  15      


His Ser Ala Leu Trp Xaa Val Gln Glu Ala Xaa Pro Leu Gly Pro Ala 
            20                  25                  30          


Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Arg 
        35                  40                  45              


Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Xaa 
    50                  55                  60                  


Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu 
65                  70                  75                  80  


Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln 
                85                  90                  95      


Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln 
            100                 105                 110         


Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Xaa 
        115                 120                 125             


Leu Asp Xaa Leu Gln Leu Asp Val Ala Asp Phe Ala Xaa Xaa Ile Trp 
    130                 135                 140                 


Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Xaa Gln 
145                 150                 155                 160 


Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly 
                165                 170                 175     


Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg 
            180                 185                 190         


Val Leu Arg His Leu Ala Gln Pro 
        195                 200 


<210> 7042
<211> 21
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<400> 7042
Met Ala Arg Leu Gly Asn Cys Ser Leu Xaa Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly 
            20      


<210> 7043
<211> 783
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<400> 7043
Met Ala Arg Leu Gly Asn Cys Ser Leu Xaa Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Xaa Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Xaa Gln Glu Ser Ile Ile Xaa Leu Pro His Leu Asn His Xaa Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Xaa Xaa Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Xaa His Leu Pro Xaa Ser Phe Xaa Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Xaa Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Xaa Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Xaa Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Xaa Ala Tyr Xaa 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Xaa Xaa Glu Arg Ala Pro Xaa Val 
                325                 330                 335     


Arg Leu Asp Xaa Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Xaa Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Xaa Xaa Glu Leu Ser Cys Xaa Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Xaa 
                405                 410                 415     


Ser Arg Pro Xaa Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Xaa Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Xaa Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Xaa Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Xaa Pro Leu Tyr Gln Asp Xaa Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Xaa Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Xaa 
545                 550                 555                 560 


His Tyr Xaa Ile Phe Trp Xaa Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Xaa Asn Ser Xaa Val Leu Xaa Leu Met Xaa Leu Xaa Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Xaa 
625                 630                 635                 640 


Cys Leu Cys Gly Xaa Ala Trp Leu Cys Cys Ser Pro Asn Arg Lys Asn 
                645                 650                 655     


Pro Leu Trp Pro Ser Val Pro Asp Pro Ala His Ser Ser Leu Gly Ser 
            660                 665                 670         


Trp Val Pro Xaa Ile Met Glu Glu Asp Ala Phe Gln Leu Pro Gly Leu 
        675                 680                 685             


Gly Xaa Pro Pro Ile Xaa Lys Leu Xaa Val Leu Glu Glu Asp Glu Lys 
    690                 695                 700                 


Lys Pro Val Pro Trp Glu Ser His Asn Ser Ser Glu Xaa Cys Gly Leu 
705                 710                 715                 720 


Pro Xaa Leu Val Gln Xaa Tyr Val Leu Gln Gly Asp Pro Arg Ala Val 
                725                 730                 735     


Ser Xaa Gln Pro Gln Ser Gln Ser Gly Xaa Ser Asp Gln Ala Gly Pro 
            740                 745                 750         


Pro Arg Arg Ser Ala Tyr Phe Lys Asp Gln Ile Met Leu His Pro Ala 
        755                 760                 765             


Pro Pro Asn Gly Leu Leu Cys Leu Phe Pro Ile Xaa Ser Val Leu 
    770                 775                 780             


<210> 7044
<211> 836
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (802)..(802)
<223> Selenocysteine

<400> 7044
Met Ala Arg Leu Gly Asn Cys Ser Leu Xaa Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Xaa Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Xaa Gln Glu Ser Ile Ile Xaa Leu Pro His Leu Asn His Xaa Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Xaa Xaa Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Xaa His Leu Pro Xaa Ser Phe Xaa Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Xaa Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Xaa Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Xaa Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Xaa Ala Tyr Xaa 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Xaa Xaa Glu Arg Ala Pro Xaa Val 
                325                 330                 335     


Arg Leu Asp Xaa Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Xaa Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Xaa Xaa Glu Leu Ser Cys Xaa Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Xaa 
                405                 410                 415     


Ser Arg Pro Xaa Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Xaa Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Xaa Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Xaa Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Xaa Pro Leu Tyr Gln Asp Xaa Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Xaa Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Xaa 
545                 550                 555                 560 


His Tyr Xaa Ile Phe Trp Xaa Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Xaa Asn Ser Xaa Val Leu Xaa Leu Met Xaa Leu Xaa Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Xaa 
625                 630                 635                 640 


Cys Leu Cys Gly Xaa Ala Trp Leu Cys Cys Ser Pro Asn Arg Lys Asn 
                645                 650                 655     


Pro Leu Trp Pro Ser Val Pro Asp Pro Ala His Ser Ser Leu Gly Ser 
            660                 665                 670         


Trp Val Pro Xaa Ile Met Glu Glu Asp Ala Phe Gln Leu Pro Gly Leu 
        675                 680                 685             


Gly Xaa Pro Pro Ile Xaa Lys Leu Xaa Val Leu Glu Glu Asp Glu Lys 
    690                 695                 700                 


Lys Pro Val Pro Trp Glu Ser His Asn Ser Ser Glu Xaa Cys Gly Leu 
705                 710                 715                 720 


Pro Xaa Leu Val Gln Xaa Tyr Val Leu Gln Gly Asp Pro Arg Ala Val 
                725                 730                 735     


Ser Xaa Gln Pro Gln Ser Gln Ser Gly Xaa Ser Asp Gln Val Leu Tyr 
            740                 745                 750         


Gly Gln Leu Leu Gly Ser Pro Xaa Ser Pro Gly Pro Gly His Tyr Leu 
        755                 760                 765             


Arg Cys Asp Ser Xaa Gln Pro Leu Leu Ala Gly Leu Xaa Pro Ser Pro 
    770                 775                 780                 


Lys Ser Tyr Glu Asn Leu Trp Phe Gln Ala Ser Pro Leu Gly Xaa Leu 
785                 790                 795                 800 


Val Xaa Pro Ala Pro Ser Gln Glu Asp Asp Cys Val Phe Gly Pro Leu 
                805                 810                 815     


Leu Asn Phe Pro Leu Leu Gln Gly Ile Arg Val His Gly Met Glu Ala 
            820                 825                 830         


Leu Gly Ser Phe 
        835     


<210> 7045
<211> 863
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (826)..(826)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<400> 7045
Met Ala Arg Leu Gly Asn Cys Ser Leu Xaa Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Xaa Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Xaa Gln Glu Ser Ile Ile Xaa Leu Pro His Leu Asn His Xaa Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Xaa Xaa Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Xaa His Leu Pro Xaa Ser Phe Xaa Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Xaa Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Xaa Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Xaa Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Xaa Ala Tyr Xaa 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Xaa Xaa Glu Arg Ala Pro Xaa Val 
                325                 330                 335     


Arg Leu Asp Xaa Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Xaa Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Xaa Xaa Glu Leu Ser Cys Xaa Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Xaa 
                405                 410                 415     


Ser Arg Pro Xaa Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Xaa Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Xaa Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Xaa Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Xaa Pro Leu Tyr Gln Asp Xaa Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Xaa Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Xaa 
545                 550                 555                 560 


His Tyr Xaa Ile Phe Trp Xaa Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Xaa Asn Ser Xaa Val Leu Xaa Leu Met Xaa Leu Xaa Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Xaa 
625                 630                 635                 640 


Cys Leu Cys Gly Xaa Ala Trp Leu Cys Cys Ser Pro Asn Arg Lys Asn 
                645                 650                 655     


Pro Leu Trp Pro Ser Val Pro Asp Pro Ala His Ser Ser Leu Gly Ser 
            660                 665                 670         


Trp Val Pro Xaa Ile Met Glu Glu Leu Pro Gly Pro Arg Gln Gly Gln 
        675                 680                 685             


Trp Leu Gly Gln Xaa Ser Glu Met Ser Arg Ala Leu Xaa Pro His Pro 
    690                 695                 700                 


Cys Val Gln Asp Ala Phe Gln Leu Pro Gly Leu Gly Xaa Pro Pro Ile 
705                 710                 715                 720 


Xaa Lys Leu Xaa Val Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp 
                725                 730                 735     


Glu Ser His Asn Ser Ser Glu Xaa Cys Gly Leu Pro Xaa Leu Val Gln 
            740                 745                 750         


Xaa Tyr Val Leu Gln Gly Asp Pro Arg Ala Val Ser Xaa Gln Pro Gln 
        755                 760                 765             


Ser Gln Ser Gly Xaa Ser Asp Gln Val Leu Tyr Gly Gln Leu Leu Gly 
    770                 775                 780                 


Ser Pro Xaa Ser Pro Gly Pro Gly His Tyr Leu Arg Cys Asp Ser Xaa 
785                 790                 795                 800 


Gln Pro Leu Leu Ala Gly Leu Xaa Pro Ser Pro Lys Ser Tyr Glu Asn 
                805                 810                 815     


Leu Trp Phe Gln Ala Ser Pro Leu Gly Xaa Leu Val Xaa Pro Ala Pro 
            820                 825                 830         


Ser Gln Glu Asp Asp Cys Val Phe Gly Pro Leu Leu Asn Phe Pro Leu 
        835                 840                 845             


Leu Gln Gly Ile Arg Val His Gly Met Glu Ala Leu Gly Ser Phe 
    850                 855                 860             


<210> 7046
<211> 388
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<400> 7046
Xaa Xaa Ser Arg Pro Xaa Pro Val Val Phe Ser Glu Ser Arg Gly Pro 
1               5                   10                  15      


Ala Leu Xaa Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp 
            20                  25                  30          


Val Gly Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu 
        35                  40                  45              


Trp Gly Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Xaa Trp Arg 
    50                  55                  60                  


Met Glu Gln Asn Gly Arg Ala Xaa Gly Phe Leu Leu Lys Ala Pro Ser 
65                  70                  75                  80  


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Xaa Trp Ala Gln 
                85                  90                  95      


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Xaa 
            100                 105                 110         


His Tyr Xaa Ile Phe Trp Xaa Asn Ala Gln Asn Gln Ser Phe Ser Ala 
        115                 120                 125             


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
    130                 135                 140                 


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
145                 150                 155                 160 


Xaa Asn Ser Xaa Val Leu Xaa Leu Met Xaa Leu Xaa Pro Glu Gly Ser 
                165                 170                 175     


Glu Leu His Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Xaa 
            180                 185                 190         


Cys Leu Cys Gly Xaa Ala Trp Leu Cys Cys Ser Pro Asn Arg Lys Asn 
        195                 200                 205             


Pro Leu Trp Pro Ser Val Pro Asp Pro Ala His Ser Ser Leu Gly Ser 
    210                 215                 220                 


Trp Val Pro Xaa Ile Met Glu Glu Asp Ala Phe Gln Leu Pro Gly Leu 
225                 230                 235                 240 


Gly Xaa Pro Pro Ile Xaa Lys Leu Xaa Val Leu Glu Glu Asp Glu Lys 
                245                 250                 255     


Lys Pro Val Pro Trp Glu Ser His Asn Ser Ser Glu Xaa Cys Gly Leu 
            260                 265                 270         


Pro Xaa Leu Val Gln Xaa Tyr Val Leu Gln Gly Asp Pro Arg Ala Val 
        275                 280                 285             


Ser Xaa Gln Pro Gln Ser Gln Ser Gly Xaa Ser Asp Gln Val Leu Tyr 
    290                 295                 300                 


Gly Gln Leu Leu Gly Ser Pro Xaa Ser Pro Gly Pro Gly His Tyr Leu 
305                 310                 315                 320 


Arg Cys Asp Ser Xaa Gln Pro Leu Leu Ala Gly Leu Xaa Pro Ser Pro 
                325                 330                 335     


Lys Ser Tyr Glu Asn Leu Trp Phe Gln Ala Ser Pro Leu Gly Xaa Leu 
            340                 345                 350         


Val Xaa Pro Ala Pro Ser Gln Glu Asp Asp Cys Val Phe Gly Pro Leu 
        355                 360                 365             


Leu Asn Phe Pro Leu Leu Gln Gly Ile Arg Val His Gly Met Glu Ala 
    370                 375                 380                 


Leu Gly Ser Phe 
385             


<210> 7047
<211> 217
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<400> 7047
Met Ala Pro Gly Ser Arg Xaa Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Xaa Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Xaa Tyr Gln Glu Phe Glu Glu Xaa Tyr Ile Pro Lys 
    50                  55                  60                  


Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Xaa Ser Phe Cys Phe 
65                  70                  75                  80  


Ser Asp Ser Ile Pro Xaa Pro Ser Asn Met Glu Glu Xaa Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Arg Phe Leu Arg Ser Met Phe Ala Asn Asn Leu Val 
        115                 120                 125             


Tyr Asp Xaa Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Xaa Leu Met Gly Arg Leu Glu Asp Gly Ser Arg Arg 
145                 150                 155                 160 


Xaa Gly Gln Ile Leu Lys Gln Xaa Tyr Ser Lys Phe Asp Xaa Asn Ser 
                165                 170                 175     


His Asn His Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Xaa Phe Leu Arg Met Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210> 7048
<211> 256
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<400> 7048
Met Ala Pro Gly Ser Arg Xaa Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Xaa Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Xaa Tyr Gln Glu Phe Glu Glu Xaa Tyr Ile Pro Lys 
    50                  55                  60                  


Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Xaa Ser Phe Cys Phe 
65                  70                  75                  80  


Ser Asp Ser Ile Pro Xaa Pro Ser Asn Met Glu Glu Xaa Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Arg Phe Leu Arg Ser Met Phe Ala Asn Asn Leu Val 
        115                 120                 125             


Tyr Asp Xaa Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Xaa Leu Met Gly Val Arg Val Ala Pro Gly Val Xaa 
145                 150                 155                 160 


Asn Pro Gly Xaa Pro Leu Ala Ser Arg Ala Gly Gly Glu Lys Tyr Cys 
                165                 170                 175     


Cys Pro Leu Phe Ser Ser Lys Ala Leu Xaa Gln Glu Asn Ser Pro Tyr 
            180                 185                 190         


Ser Ser Phe Arg Leu Val Asn Pro Pro Gly Leu Ser Leu His Pro Glu 
        195                 200                 205             


Gly Glu Gly Gly Lys Trp Ile Asn Glu Arg Gly Arg Glu Gln Cys Pro 
    210                 215                 220                 


Ser Ala Trp Pro Leu Leu Leu Phe Leu His Phe Ala Glu Ala Gly Arg 
225                 230                 235                 240 


Arg Gln Pro Pro Asp Trp Ala Asp Pro Gln Ala Asp Leu Gln Gln Val 
                245                 250                 255     


<210> 7049
<211> 122
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<400> 7049
Met Ala Pro Gly Ser Arg Xaa Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Xaa Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Xaa Tyr Gln Glu Phe Arg Leu Glu Asp Gly Ser Arg 
    50                  55                  60                  


Arg Xaa Gly Gln Ile Leu Lys Gln Xaa Tyr Ser Lys Phe Asp Xaa Asn 
65                  70                  75                  80  


Ser His Asn His Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys 
                85                  90                  95      


Phe Arg Lys Asp Met Asp Lys Val Glu Xaa Phe Leu Arg Met Val Gln 
            100                 105                 110         


Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
        115                 120         


<210> 7050
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<400> 7050
Met Glu Glu Xaa Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser 
1               5                   10                  15      


Leu Leu Leu Ile Glu Ser Trp Leu Glu Pro Val Arg Phe Leu Arg Ser 
            20                  25                  30          


Met Phe Ala Asn Asn Leu Val Tyr Asp Xaa Ser Asp Ser Asp Asp Tyr 
        35                  40                  45              


His Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Xaa Leu Met Gly Arg 
    50                  55                  60                  


Leu Glu Asp Gly Ser Arg Arg Xaa Gly Gln Ile Leu Lys Gln Xaa Tyr 
65                  70                  75                  80  


Ser Lys Phe Asp Xaa Asn Ser His Asn His Asp Ala Leu Leu Lys Asn 
                85                  90                  95      


Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Xaa 
            100                 105                 110         


Phe Leu Arg Met Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
        115                 120                 125             


<210> 7051
<211> 68
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<400> 7051
Met Pro Trp Phe His Gly Lys Ile Xaa Arg Glu Gln Ala Glu Arg Leu 
1               5                   10                  15      


Leu Tyr Pro Pro Glu Xaa Gly Leu Phe Leu Val Arg Glu Ser Xaa Asn 
            20                  25                  30          


Tyr Pro Gly Asp Tyr Xaa Leu Cys Val Ser Cys Asp Gly Lys Val Glu 
        35                  40                  45              


His Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu 
    50                  55                  60                  


Val Tyr Phe Glu 
65              


<210> 7052
<211> 65
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<400> 7052
Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Xaa Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Xaa Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Xaa Ile Val Ala Val Xaa Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val 
65  


<210> 7053
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 7053
Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Xaa Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Xaa Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Xaa Ile Val Ala Val Xaa Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Xaa Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Xaa Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Xaa Gly Leu Phe Leu Val Arg Glu Ser Xaa 
            100                 105                 110 


<210> 7054
<211> 450
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<400> 7054
Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Xaa Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Xaa Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Xaa Ile Val Ala Val Xaa Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Xaa Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Xaa Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Xaa Gly Leu Phe Leu Val Arg Glu Ser Xaa Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Xaa Leu Cys Val Ser Cys Asp Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Xaa Ser Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Xaa Arg Leu Ile Lys Pro Lys Val Met Glu Gly Xaa 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Xaa Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Xaa Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Xaa Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Xaa Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Xaa 
                325                 330                 335     


Lys Glu Ala Ser Ser Xaa Gln Asp Xaa Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Xaa Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Xaa Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Xaa His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210> 7055
<211> 78
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<400> 7055
Met Ala Ser Ser Ser Gly Ser Lys Ala Glu Phe Ile Val Gly Gly Lys 
1               5                   10                  15      


Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Ile Tyr 
            20                  25                  30          


Leu Ala Ile Asn Ile Xaa Asn Gly Glu Glu Val Ala Val Lys Leu Glu 
        35                  40                  45              


Ser Gln Lys Ala Arg His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
    50                  55                  60                  


Lys Ile Leu Gln Gly Gly Val Gly Ile Pro His Ile Arg Met 
65                  70                  75              


<210> 7056
<211> 89
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<400> 7056
Met Ala Ser Ser Ser Gly Ser Lys Ala Glu Phe Ile Val Gly Gly Lys 
1               5                   10                  15      


Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Ile Tyr 
            20                  25                  30          


Leu Ala Ile Asn Ile Xaa Asn Gly Glu Glu Val Ala Val Lys Leu Glu 
        35                  40                  45              


Ser Gln Lys Ala Arg His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
    50                  55                  60                  


Lys Ile Leu Gln Gly Gly Val Gly Ile Pro His Ile Arg Ser Pro Glu 
65                  70                  75                  80  


Trp Ile Lys Pro Leu Lys Ser Gln Glu 
                85                  


<210> 7057
<211> 365
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<400> 7057
Met Ala Ser Ser Ser Gly Ser Lys Ala Glu Phe Ile Val Gly Gly Lys 
1               5                   10                  15      


Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Ile Tyr 
            20                  25                  30          


Leu Ala Ile Asn Ile Xaa Asn Gly Glu Glu Val Ala Val Lys Leu Glu 
        35                  40                  45              


Ser Gln Lys Ala Arg His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
    50                  55                  60                  


Lys Ile Leu Gln Gly Gly Val Gly Ile Pro His Ile Arg Trp Tyr Gly 
65                  70                  75                  80  


Gln Glu Lys Asp Tyr Asn Val Leu Val Met Asp Leu Leu Gly Pro Ser 
                85                  90                  95      


Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg Arg Phe Xaa Met Lys Xaa 
            100                 105                 110         


Val Leu Met Leu Ala Asp Gln Met Ile Ser Arg Ile Glu Tyr Val His 
        115                 120                 125             


Xaa Lys Asn Phe Ile His Arg Asp Ile Lys Pro Asp Asn Phe Leu Met 
    130                 135                 140                 


Gly Ile Gly Arg His Cys Asn Lys Cys Leu Glu Ser Pro Val Gly Lys 
145                 150                 155                 160 


Arg Lys Arg Ser Met Xaa Val Ser Xaa Ser Gln Asp Pro Ser Phe Ser 
                165                 170                 175     


Gly Leu Asn Gln Leu Phe Leu Ile Asp Phe Gly Leu Ala Lys Lys Tyr 
            180                 185                 190         


Arg Asp Asn Arg Xaa Arg Gln His Ile Pro Tyr Arg Glu Asp Lys Asn 
        195                 200                 205             


Leu Xaa Gly Xaa Ala Arg Tyr Ala Ser Ile Asn Ala His Leu Gly Ile 
    210                 215                 220                 


Glu Gln Ser Arg Arg Asp Asp Met Glu Ser Leu Gly Tyr Val Leu Met 
225                 230                 235                 240 


Tyr Phe Asn Arg Xaa Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Xaa 
                245                 250                 255     


Lys Lys Gln Lys Tyr Glu Lys Ile Ser Glu Lys Lys Met Ser Xaa Pro 
            260                 265                 270         


Val Glu Val Leu Cys Lys Gly Phe Pro Ala Glu Phe Ala Met Tyr Leu 
        275                 280                 285             


Asn Tyr Cys Arg Gly Leu Arg Phe Glu Glu Ala Pro Asp Tyr Met Tyr 
    290                 295                 300                 


Leu Arg Gln Leu Phe Arg Ile Leu Phe Arg Xaa Leu Asn His Gln Tyr 
305                 310                 315                 320 


Asp Tyr Xaa Phe Asp Trp Xaa Met Leu Lys Gln Lys Ala Ala Gln Gln 
                325                 330                 335     


Ala Ala Ser Ser Ser Gly Gln Gly Gln Gln Ala Gln Xaa Pro Xaa Gly 
            340                 345                 350         


Lys Gln Xaa Asp Lys Xaa Lys Ser Asn Met Lys Gly Phe 
        355                 360                 365 


<210> 7058
<211> 325
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<400> 7058
Met Ala Ser Ser Ser Gly Ser Lys Ala Glu Phe Ile Val Gly Gly Lys 
1               5                   10                  15      


Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Ile Tyr 
            20                  25                  30          


Leu Ala Ile Asn Ile Xaa Asn Gly Glu Glu Val Ala Val Lys Leu Glu 
        35                  40                  45              


Ser Gln Lys Ala Arg His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
    50                  55                  60                  


Lys Ile Leu Gln Gly Gly Val Gly Ile Pro His Ile Arg Trp Tyr Gly 
65                  70                  75                  80  


Gln Glu Lys Asp Tyr Asn Val Leu Val Met Asp Leu Leu Gly Pro Ser 
                85                  90                  95      


Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg Arg Phe Xaa Met Lys Xaa 
            100                 105                 110         


Val Leu Met Leu Ala Asp Gln Met Ile Ser Arg Ile Glu Tyr Val His 
        115                 120                 125             


Xaa Lys Asn Phe Ile His Arg Asp Ile Lys Pro Asp Asn Phe Leu Met 
    130                 135                 140                 


Gly Ile Gly Arg His Cys Asn Lys Leu Phe Leu Ile Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Lys Lys Tyr Arg Asp Asn Arg Xaa Arg Gln His Ile Pro Tyr Arg 
                165                 170                 175     


Glu Asp Lys Asn Leu Xaa Gly Xaa Ala Arg Tyr Ala Ser Ile Asn Ala 
            180                 185                 190         


His Leu Gly Ile Glu Gln Ser Arg Arg Asp Asp Met Glu Ser Leu Gly 
        195                 200                 205             


Tyr Val Leu Met Tyr Phe Asn Arg Xaa Ser Leu Pro Trp Gln Gly Leu 
    210                 215                 220                 


Lys Ala Ala Xaa Lys Lys Gln Lys Tyr Glu Lys Ile Ser Glu Lys Lys 
225                 230                 235                 240 


Met Ser Xaa Pro Val Glu Val Leu Cys Lys Gly Phe Pro Ala Glu Phe 
                245                 250                 255     


Ala Met Tyr Leu Asn Tyr Cys Arg Gly Leu Arg Phe Glu Glu Ala Pro 
            260                 265                 270         


Asp Tyr Met Tyr Leu Arg Gln Leu Phe Arg Ile Leu Phe Arg Xaa Leu 
        275                 280                 285             


Asn His Gln Tyr Asp Tyr Xaa Phe Asp Trp Xaa Met Leu Lys Gln Lys 
    290                 295                 300                 


Ala Ala Gln Gln Ala Ala Ser Ser Ser Gly Gln Gly Gln Gln Ala Gln 
305                 310                 315                 320 


Xaa Pro Xaa Gly Phe 
                325 


<210> 7059
<211> 337
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<400> 7059
Met Ala Ser Ser Ser Gly Ser Lys Ala Glu Phe Ile Val Gly Gly Lys 
1               5                   10                  15      


Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Ile Tyr 
            20                  25                  30          


Leu Ala Ile Asn Ile Xaa Asn Gly Glu Glu Val Ala Val Lys Leu Glu 
        35                  40                  45              


Ser Gln Lys Ala Arg His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
    50                  55                  60                  


Lys Ile Leu Gln Gly Gly Val Gly Ile Pro His Ile Arg Trp Tyr Gly 
65                  70                  75                  80  


Gln Glu Lys Asp Tyr Asn Val Leu Val Met Asp Leu Leu Gly Pro Ser 
                85                  90                  95      


Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg Arg Phe Xaa Met Lys Xaa 
            100                 105                 110         


Val Leu Met Leu Ala Asp Gln Met Ile Ser Arg Ile Glu Tyr Val His 
        115                 120                 125             


Xaa Lys Asn Phe Ile His Arg Asp Ile Lys Pro Asp Asn Phe Leu Met 
    130                 135                 140                 


Gly Ile Gly Arg His Cys Asn Lys Leu Phe Leu Ile Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Lys Lys Tyr Arg Asp Asn Arg Xaa Arg Gln His Ile Pro Tyr Arg 
                165                 170                 175     


Glu Asp Lys Asn Leu Xaa Gly Xaa Ala Arg Tyr Ala Ser Ile Asn Ala 
            180                 185                 190         


His Leu Gly Ile Glu Gln Ser Arg Arg Asp Asp Met Glu Ser Leu Gly 
        195                 200                 205             


Tyr Val Leu Met Tyr Phe Asn Arg Xaa Ser Leu Pro Trp Gln Gly Leu 
    210                 215                 220                 


Lys Ala Ala Xaa Lys Lys Gln Lys Tyr Glu Lys Ile Ser Glu Lys Lys 
225                 230                 235                 240 


Met Ser Xaa Pro Val Glu Val Leu Cys Lys Gly Phe Pro Ala Glu Phe 
                245                 250                 255     


Ala Met Tyr Leu Asn Tyr Cys Arg Gly Leu Arg Phe Glu Glu Ala Pro 
            260                 265                 270         


Asp Tyr Met Tyr Leu Arg Gln Leu Phe Arg Ile Leu Phe Arg Xaa Leu 
        275                 280                 285             


Asn His Gln Tyr Asp Tyr Xaa Phe Asp Trp Xaa Met Leu Lys Gln Lys 
    290                 295                 300                 


Ala Ala Gln Gln Ala Ala Ser Ser Ser Gly Gln Gly Gln Gln Ala Gln 
305                 310                 315                 320 


Xaa Pro Xaa Gly Lys Gln Xaa Asp Lys Xaa Lys Ser Asn Met Lys Gly 
                325                 330                 335     


Phe 
    


<210> 7060
<211> 264
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<400> 7060
Met Asp Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asn Phe Cys Ser 
1               5                   10                  15      


Arg Arg Phe Xaa Met Lys Xaa Val Leu Met Leu Ala Asp Gln Met Ile 
            20                  25                  30          


Ser Arg Ile Glu Tyr Val His Xaa Lys Asn Phe Ile His Arg Asp Ile 
        35                  40                  45              


Lys Pro Asp Asn Phe Leu Met Gly Ile Gly Arg His Cys Asn Lys Cys 
    50                  55                  60                  


Leu Glu Ser Pro Val Gly Lys Arg Lys Arg Ser Met Xaa Val Ser Xaa 
65                  70                  75                  80  


Ser Gln Asp Pro Ser Phe Ser Gly Leu Asn Gln Leu Phe Leu Ile Asp 
                85                  90                  95      


Phe Gly Leu Ala Lys Lys Tyr Arg Asp Asn Arg Xaa Arg Gln His Ile 
            100                 105                 110         


Pro Tyr Arg Glu Asp Lys Asn Leu Xaa Gly Xaa Ala Arg Tyr Ala Ser 
        115                 120                 125             


Ile Asn Ala His Leu Gly Ile Glu Gln Ser Arg Arg Asp Asp Met Glu 
    130                 135                 140                 


Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Arg Xaa Ser Leu Pro Trp 
145                 150                 155                 160 


Gln Gly Leu Lys Ala Ala Xaa Lys Lys Gln Lys Tyr Glu Lys Ile Ser 
                165                 170                 175     


Glu Lys Lys Met Ser Xaa Pro Val Glu Val Leu Cys Lys Gly Phe Pro 
            180                 185                 190         


Ala Glu Phe Ala Met Tyr Leu Asn Tyr Cys Arg Gly Leu Arg Phe Glu 
        195                 200                 205             


Glu Ala Pro Asp Tyr Met Tyr Leu Arg Gln Leu Phe Arg Ile Leu Phe 
    210                 215                 220                 


Arg Xaa Leu Asn His Gln Tyr Asp Tyr Xaa Phe Asp Trp Xaa Met Leu 
225                 230                 235                 240 


Lys Gln Lys Ala Ala Gln Gln Ala Ala Ser Ser Ser Gly Gln Gly Gln 
                245                 250                 255     


Gln Ala Gln Xaa Pro Xaa Gly Phe 
            260                 


<210> 7061
<211> 236
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<400> 7061
Met Asp Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asn Phe Cys Ser 
1               5                   10                  15      


Arg Arg Phe Xaa Met Lys Xaa Val Leu Met Leu Ala Asp Gln Met Ile 
            20                  25                  30          


Ser Arg Ile Glu Tyr Val His Xaa Lys Asn Phe Ile His Arg Asp Ile 
        35                  40                  45              


Lys Pro Asp Asn Phe Leu Met Gly Ile Gly Arg His Cys Asn Lys Leu 
    50                  55                  60                  


Phe Leu Ile Asp Phe Gly Leu Ala Lys Lys Tyr Arg Asp Asn Arg Xaa 
65                  70                  75                  80  


Arg Gln His Ile Pro Tyr Arg Glu Asp Lys Asn Leu Xaa Gly Xaa Ala 
                85                  90                  95      


Arg Tyr Ala Ser Ile Asn Ala His Leu Gly Ile Glu Gln Ser Arg Arg 
            100                 105                 110         


Asp Asp Met Glu Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Arg Xaa 
        115                 120                 125             


Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Xaa Lys Lys Gln Lys Tyr 
    130                 135                 140                 


Glu Lys Ile Ser Glu Lys Lys Met Ser Xaa Pro Val Glu Val Leu Cys 
145                 150                 155                 160 


Lys Gly Phe Pro Ala Glu Phe Ala Met Tyr Leu Asn Tyr Cys Arg Gly 
                165                 170                 175     


Leu Arg Phe Glu Glu Ala Pro Asp Tyr Met Tyr Leu Arg Gln Leu Phe 
            180                 185                 190         


Arg Ile Leu Phe Arg Xaa Leu Asn His Gln Tyr Asp Tyr Xaa Phe Asp 
        195                 200                 205             


Trp Xaa Met Leu Lys Gln Lys Ala Ala Gln Gln Ala Ala Ser Ser Ser 
    210                 215                 220                 


Gly Gln Gly Gln Gln Ala Gln Xaa Pro Xaa Gly Phe 
225                 230                 235     


<210> 7062
<211> 134
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 7062
Met Glu Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Arg Xaa Ser Leu 
1               5                   10                  15      


Pro Trp Gln Gly Leu Lys Ala Ala Xaa Lys Lys Gln Lys Tyr Glu Lys 
            20                  25                  30          


Ile Ser Glu Lys Lys Met Ser Xaa Pro Val Glu Val Leu Cys Lys Gly 
        35                  40                  45              


Phe Pro Ala Glu Phe Ala Met Tyr Leu Asn Tyr Cys Arg Gly Leu Arg 
    50                  55                  60                  


Phe Glu Glu Ala Pro Asp Tyr Met Tyr Leu Arg Gln Leu Phe Arg Ile 
65                  70                  75                  80  


Leu Phe Arg Xaa Leu Asn His Gln Tyr Asp Tyr Xaa Phe Asp Trp Xaa 
                85                  90                  95      


Met Leu Lys Gln Lys Ala Ala Gln Gln Ala Ala Ser Ser Ser Gly Gln 
            100                 105                 110         


Gly Gln Gln Ala Gln Xaa Pro Xaa Gly Lys Gln Xaa Asp Lys Xaa Lys 
        115                 120                 125             


Ser Asn Met Lys Gly Phe 
    130                 


<210> 7063
<211> 166
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<400> 7063
Met Phe Leu Val Leu Lys Lys Lys His Ile Cys His Arg Asn Leu Val 
1               5                   10                  15      


Asn Ile Leu Gln Leu Asn Met Tyr Val Cys Cys Leu Asp Lys Cys Asn 
            20                  25                  30          


His Cys Lys His Leu Tyr Asp Leu Gly Phe Cys Phe Tyr Phe Glu Met 
        35                  40                  45              


Gly Ala Phe Leu Phe Xaa Ser Ser Leu Lys Xaa Lys Asn Cys Phe Cys 
    50                  55                  60                  


Lys Glu Met Arg Phe Phe Leu Asn Asn Lys Lys Cys Leu Ala Asp Ser 
65                  70                  75                  80  


Leu Leu Asn Lys Asn Leu Pro Asn Phe Leu Ile Asp Tyr Phe Lys Pro 
                85                  90                  95      


Phe Val Xaa Trp Tyr Ser Phe Ala Ser Gln Phe Arg Phe Arg Val Ile 
            100                 105                 110         


Xaa Phe Pro Leu Phe Leu Arg Lys Met Lys Lys Val Ile Leu Leu Ser 
        115                 120                 125             


Glu Gly Glu Arg His Ser Phe Ile Phe Phe Phe Phe Phe Phe Phe Phe 
    130                 135                 140                 


Tyr Asp Leu Gln Ala Gln Tyr Leu Val Leu Gln Leu Pro Glu Leu Gly 
145                 150                 155                 160 


Ile Val Ala Ala Ala Arg 
                165     


<210> 7064
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<400> 7064
Met Ser Xaa Pro Val Glu Val Leu Cys Lys Gly Phe Pro Ala Glu Phe 
1               5                   10                  15      


Ala Met Tyr Leu Asn Tyr Cys Arg Gly Leu Arg Phe Glu Glu Ala Pro 
            20                  25                  30          


Asp Tyr Met Tyr Leu Arg Gln Leu Phe Arg Ile Leu Phe Arg Xaa Leu 
        35                  40                  45              


Asn His Gln Tyr Asp Tyr Xaa Phe Asp Trp Xaa Met Leu Lys Gln Lys 
    50                  55                  60                  


Ala Ala Gln Gln Ala Ala Ser Ser Ser Gly Gln Gly Gln Gln Ala Gln 
65                  70                  75                  80  


Xaa Pro Xaa Gly Lys Gln Xaa Asp Lys Xaa Lys Ser Asn Met Lys Gly 
                85                  90                  95      


<210> 7065
<211> 184
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<400> 7065
Xaa Gly Xaa Ala Arg Tyr Ala Ser Ile Asn Ala His Leu Gly Ile Glu 
1               5                   10                  15      


Gln Ser Arg Arg Asp Asp Met Glu Ser Leu Gly Tyr Val Leu Met Tyr 
            20                  25                  30          


Phe Asn Arg Xaa Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Xaa Lys 
        35                  40                  45              


Lys Gln Lys Tyr Glu Lys Ile Ser Glu Lys Lys Met Ser Xaa Pro Val 
    50                  55                  60                  


Glu Val Leu Cys Lys Gly Phe Pro Ala Glu Phe Ala Met Tyr Leu Asn 
65                  70                  75                  80  


Tyr Cys Arg Gly Leu Arg Phe Glu Glu Ala Pro Asp Tyr Met Tyr Leu 
                85                  90                  95      


Arg Gln Leu Phe Arg Ile Leu Phe Arg Xaa Leu Asn His Gln Tyr Asp 
            100                 105                 110         


Tyr Xaa Phe Asp Trp Xaa Met Leu Lys Gln Lys Ala Ala Gln Gln Ala 
        115                 120                 125             


Ala Ser Ser Ser Gly Gln Gly Gln Gln Ala Gln Xaa Pro Xaa Gly Lys 
    130                 135                 140                 


Gln Xaa Asp Lys Xaa Lys Ser Asn Met Lys Gly Asn Ala Asp Glu Ser 
145                 150                 155                 160 


Ala Arg Val Gly Leu Trp Ser Ser Gly Val His Val Ser Lys Xaa Ala 
                165                 170                 175     


Gly Pro Ser Asn Ser Ala Xaa Cys 
            180                 


<210> 7066
<211> 167
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<400> 7066
Xaa Gln His Ile Pro Tyr Arg Glu Asp Lys Asn Leu Xaa Gly Xaa Ala 
1               5                   10                  15      


Arg Tyr Ala Ser Ile Asn Ala His Leu Gly Ile Glu Gln Ser Arg Arg 
            20                  25                  30          


Asp Asp Met Glu Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Arg Xaa 
        35                  40                  45              


Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Xaa Lys Lys Gln Lys Tyr 
    50                  55                  60                  


Glu Lys Ile Ser Glu Lys Lys Met Ser Xaa Pro Val Glu Val Leu Cys 
65                  70                  75                  80  


Lys Gly Phe Pro Ala Glu Phe Ala Met Tyr Leu Asn Tyr Cys Arg Gly 
                85                  90                  95      


Leu Arg Phe Glu Glu Ala Pro Asp Tyr Met Tyr Leu Arg Gln Leu Phe 
            100                 105                 110         


Arg Ile Leu Phe Arg Xaa Leu Asn His Gln Tyr Asp Tyr Xaa Phe Asp 
        115                 120                 125             


Trp Xaa Met Leu Lys Gln Lys Ala Ala Gln Gln Ala Ala Ser Ser Ser 
    130                 135                 140                 


Gly Gln Gly Gln Gln Ala Gln Xaa Pro Xaa Gly Lys Gln Xaa Asp Lys 
145                 150                 155                 160 


Xaa Lys Ser Asn Met Lys Gly 
                165         


<210> 7067
<211> 337
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<400> 7067
Met Xaa Asn Asn Ser Gly Ser Lys Ala Glu Leu Val Val Gly Gly Lys 
1               5                   10                  15      


Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Val Tyr 
            20                  25                  30          


Leu Gly Ile Xaa Xaa Xaa Asn Gly Glu Asp Val Ala Val Lys Leu Glu 
        35                  40                  45              


Ser Gln Lys Val Lys His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
    50                  55                  60                  


Xaa Ile Leu Gln Gly Gly Val Gly Ile Pro His Met His Trp Tyr Gly 
65                  70                  75                  80  


Gln Glu Lys Asp Asn Asn Val Leu Val Met Asp Leu Leu Gly Pro Ser 
                85                  90                  95      


Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg Arg Phe Xaa Met Lys Xaa 
            100                 105                 110         


Val Leu Met Leu Ala Asp Gln Met Ile Ser Arg Ile Glu Tyr Val His 
        115                 120                 125             


Xaa Lys Asn Phe Leu His Arg Asp Ile Lys Pro Asp Asn Phe Leu Met 
    130                 135                 140                 


Gly Xaa Gly Arg His Cys Asn Lys Leu Phe Leu Ile Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Lys Lys Tyr Arg Asp Asn Arg Xaa Arg Gln His Ile Pro Tyr Arg 
                165                 170                 175     


Glu Asp Lys His Leu Ile Gly Xaa Val Arg Tyr Ala Ser Ile Asn Ala 
            180                 185                 190         


His Leu Gly Ile Glu Gln Ser Arg Arg Asp Asp Met Glu Ser Leu Gly 
        195                 200                 205             


Tyr Val Phe Met Tyr Phe Asn Arg Xaa Ser Leu Pro Trp Gln Gly Leu 
    210                 215                 220                 


Arg Ala Met Xaa Lys Lys Gln Lys Tyr Glu Lys Ile Ser Glu Lys Lys 
225                 230                 235                 240 


Met Ser Xaa Pro Val Glu Val Leu Cys Lys Gly Phe Pro Ala Glu Phe 
                245                 250                 255     


Ala Met Tyr Leu Asn Tyr Cys Arg Gly Leu Arg Phe Glu Glu Val Pro 
            260                 265                 270         


Asp Tyr Met Tyr Leu Arg Gln Leu Phe Arg Ile Leu Phe Arg Xaa Leu 
        275                 280                 285             


Asn His Gln Tyr Asp Tyr Xaa Phe Asp Trp Xaa Met Leu Lys Gln Lys 
    290                 295                 300                 


Ala Ala Gln Gln Ala Ala Ser Ser Ser Gly Gln Gly Gln Gln Ala Gln 
305                 310                 315                 320 


Xaa Gln Xaa Gly Lys Gln Xaa Glu Lys Asn Lys Asn Asn Val Lys Asp 
                325                 330                 335     


Asn 
    


<210> 7068
<211> 409
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<400> 7068
Met Glu Leu Arg Val Gly Asn Arg Tyr Arg Leu Gly Arg Lys Ile Gly 
1               5                   10                  15      


Ser Gly Ser Phe Gly Asp Ile Tyr Leu Gly Xaa Asp Ile Ala Ala Gly 
            20                  25                  30          


Glu Glu Val Ala Ile Lys Leu Glu Cys Val Lys Xaa Lys His Pro Gln 
        35                  40                  45              


Leu His Ile Glu Ser Lys Ile Tyr Lys Met Met Gln Gly Gly Val Gly 
    50                  55                  60                  


Ile Pro Xaa Ile Arg Trp Cys Gly Ala Glu Gly Asp Tyr Asn Val Met 
65                  70                  75                  80  


Val Met Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asn Phe Cys 
                85                  90                  95      


Ser Arg Lys Phe Ser Leu Lys Xaa Val Leu Leu Leu Ala Asp Gln Met 
            100                 105                 110         


Ile Ser Arg Ile Glu Tyr Ile His Ser Lys Asn Phe Ile His Arg Asp 
        115                 120                 125             


Val Lys Pro Asp Asn Phe Leu Met Gly Leu Gly Lys Lys Gly Asn Leu 
    130                 135                 140                 


Val Tyr Ile Ile Asp Phe Gly Leu Ala Lys Lys Tyr Arg Asp Ala Arg 
145                 150                 155                 160 


Xaa His Gln His Ile Pro Tyr Arg Glu Asn Lys Asn Leu Xaa Gly Xaa 
                165                 170                 175     


Ala Arg Tyr Ala Ser Ile Asn Xaa His Leu Gly Ile Glu Gln Ser Arg 
            180                 185                 190         


Arg Asp Asp Leu Glu Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Leu 
        195                 200                 205             


Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Xaa Lys Arg Gln Lys 
    210                 215                 220                 


Tyr Glu Arg Ile Ser Glu Lys Lys Met Ser Xaa Pro Ile Glu Val Leu 
225                 230                 235                 240 


Cys Lys Gly Tyr Pro Ser Glu Phe Ala Xaa Tyr Leu Asn Phe Cys Arg 
                245                 250                 255     


Ser Leu Arg Phe Asp Asp Lys Pro Asp Tyr Ser Tyr Leu Arg Gln Leu 
            260                 265                 270         


Phe Arg Asn Leu Phe His Arg Gln Gly Phe Ser Tyr Asp Tyr Val Phe 
        275                 280                 285             


Asp Trp Asn Met Leu Lys Phe Gly Ala Ser Arg Ala Ala Asp Asp Ala 
    290                 295                 300                 


Glu Arg Glu Arg Arg Asp Arg Glu Glu Arg Leu Arg His Ser Arg Asn 
305                 310                 315                 320 


Pro Ala Xaa Arg Gly Leu Pro Ser Xaa Ala Ser Gly Arg Leu Arg Gly 
                325                 330                 335     


Xaa Gln Glu Val Ala Pro Pro Xaa Pro Leu Xaa Pro Xaa Ser His Xaa 
            340                 345                 350         


Ala Asn Xaa Ser Pro Arg Pro Val Ser Gly Met Glu Arg Glu Arg Lys 
        355                 360                 365             


Val Ser Met Arg Leu His Arg Gly Ala Pro Val Asn Ile Ser Ser Ser 
    370                 375                 380                 


Asp Leu Xaa Gly Arg Gln Asp Xaa Ser Arg Met Ser Xaa Ser Gln Asn 
385                 390                 395                 400 


Ser Ile Pro Phe Glu His His Gly Lys 
                405                 


<210> 7069
<211> 415
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<400> 7069
Met Glu Leu Arg Val Gly Asn Arg Tyr Arg Leu Gly Arg Lys Ile Gly 
1               5                   10                  15      


Ser Gly Ser Phe Gly Asp Ile Tyr Leu Gly Xaa Asp Ile Ala Ala Gly 
            20                  25                  30          


Glu Glu Val Ala Ile Lys Leu Glu Cys Val Lys Xaa Lys His Pro Gln 
        35                  40                  45              


Leu His Ile Glu Ser Lys Ile Tyr Lys Met Met Gln Gly Gly Val Gly 
    50                  55                  60                  


Ile Pro Xaa Ile Arg Trp Cys Gly Ala Glu Gly Asp Tyr Asn Val Met 
65                  70                  75                  80  


Val Met Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asn Phe Cys 
                85                  90                  95      


Ser Arg Lys Phe Ser Leu Lys Xaa Val Leu Leu Leu Ala Asp Gln Met 
            100                 105                 110         


Ile Ser Arg Ile Glu Tyr Ile His Ser Lys Asn Phe Ile His Arg Asp 
        115                 120                 125             


Val Lys Pro Asp Asn Phe Leu Met Gly Leu Gly Lys Lys Gly Asn Leu 
    130                 135                 140                 


Val Tyr Ile Ile Asp Phe Gly Leu Ala Lys Lys Tyr Arg Asp Ala Arg 
145                 150                 155                 160 


Xaa His Gln His Ile Pro Tyr Arg Glu Asn Lys Asn Leu Xaa Gly Xaa 
                165                 170                 175     


Ala Arg Tyr Ala Ser Ile Asn Xaa His Leu Gly Ile Glu Gln Ser Arg 
            180                 185                 190         


Arg Asp Asp Leu Glu Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Leu 
        195                 200                 205             


Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Xaa Lys Arg Gln Lys 
    210                 215                 220                 


Tyr Glu Arg Ile Ser Glu Lys Lys Met Ser Xaa Pro Ile Glu Val Leu 
225                 230                 235                 240 


Cys Lys Gly Tyr Pro Ser Glu Phe Ala Xaa Tyr Leu Asn Phe Cys Arg 
                245                 250                 255     


Ser Leu Arg Phe Asp Asp Lys Pro Asp Tyr Ser Tyr Leu Arg Gln Leu 
            260                 265                 270         


Phe Arg Asn Leu Phe His Arg Gln Gly Phe Ser Tyr Asp Tyr Val Phe 
        275                 280                 285             


Asp Trp Asn Met Leu Lys Phe Gly Ala Ser Arg Ala Ala Asp Asp Ala 
    290                 295                 300                 


Glu Arg Glu Arg Arg Asp Arg Glu Glu Arg Leu Arg His Ser Arg Asn 
305                 310                 315                 320 


Pro Ala Xaa Arg Gly Leu Pro Ser Xaa Ala Ser Gly Arg Leu Arg Gly 
                325                 330                 335     


Xaa Gln Glu Val Ala Pro Pro Xaa Pro Leu Xaa Pro Xaa Ser His Xaa 
            340                 345                 350         


Ala Asn Xaa Ser Pro Arg Pro Val Ser Gly Met Glu Arg Glu Arg Lys 
        355                 360                 365             


Val Ser Met Arg Leu His Arg Gly Ala Pro Val Asn Ile Ser Ser Ser 
    370                 375                 380                 


Asp Leu Xaa Gly Arg Gln Asp Xaa Ser Arg Met Ser Xaa Ser Gln Ile 
385                 390                 395                 400 


Pro Gly Arg Val Ala Ser Ser Gly Leu Gln Ser Val Val His Arg 
                405                 410                 415 


<210> 7070
<211> 427
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<400> 7070
Met Glu Leu Arg Val Gly Asn Arg Tyr Arg Leu Gly Arg Lys Ile Gly 
1               5                   10                  15      


Ser Gly Ser Phe Gly Asp Ile Tyr Leu Gly Xaa Asp Ile Ala Ala Gly 
            20                  25                  30          


Glu Glu Val Ala Ile Lys Leu Glu Cys Val Lys Xaa Lys His Pro Gln 
        35                  40                  45              


Leu His Ile Glu Ser Lys Ile Tyr Lys Met Met Gln Gly Gly Val Gly 
    50                  55                  60                  


Ile Pro Xaa Ile Arg Trp Cys Gly Ala Glu Gly Asp Tyr Asn Val Met 
65                  70                  75                  80  


Val Met Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asn Phe Cys 
                85                  90                  95      


Ser Arg Lys Phe Ser Leu Lys Xaa Val Leu Leu Leu Ala Asp Gln Met 
            100                 105                 110         


Ile Ser Arg Ile Glu Tyr Ile His Ser Lys Asn Phe Ile His Arg Asp 
        115                 120                 125             


Val Lys Pro Asp Asn Phe Leu Met Gly Leu Gly Lys Lys Gly Asn Leu 
    130                 135                 140                 


Val Tyr Ile Ile Asp Phe Gly Leu Ala Lys Lys Tyr Arg Asp Ala Arg 
145                 150                 155                 160 


Xaa His Gln His Ile Pro Tyr Arg Glu Asn Lys Asn Leu Xaa Gly Xaa 
                165                 170                 175     


Ala Arg Tyr Ala Ser Ile Asn Xaa His Leu Gly Ile Glu Gln Ser Arg 
            180                 185                 190         


Arg Asp Asp Leu Glu Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Leu 
        195                 200                 205             


Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Xaa Lys Arg Gln Lys 
    210                 215                 220                 


Tyr Glu Arg Ile Ser Glu Lys Lys Met Ser Xaa Pro Ile Glu Val Leu 
225                 230                 235                 240 


Cys Lys Gly Tyr Pro Ser Glu Phe Ala Xaa Tyr Leu Asn Phe Cys Arg 
                245                 250                 255     


Ser Leu Arg Phe Asp Asp Lys Pro Asp Tyr Ser Tyr Leu Arg Gln Leu 
            260                 265                 270         


Phe Arg Asn Leu Phe His Arg Gln Gly Phe Ser Tyr Asp Tyr Val Phe 
        275                 280                 285             


Asp Trp Asn Met Leu Lys Phe Gly Ala Ser Arg Ala Ala Asp Asp Ala 
    290                 295                 300                 


Glu Arg Glu Arg Arg Asp Arg Glu Glu Arg Leu Arg His Ser Arg Asn 
305                 310                 315                 320 


Pro Ala Xaa Arg Gly Leu Pro Ser Xaa Ala Ser Gly Arg Leu Arg Gly 
                325                 330                 335     


Xaa Gln Glu Val Ala Pro Pro Xaa Pro Leu Xaa Pro Xaa Ser His Xaa 
            340                 345                 350         


Ala Asn Xaa Ser Pro Arg Pro Val Ser Gly Met Glu Arg Glu Arg Lys 
        355                 360                 365             


Val Ser Met Arg Leu His Arg Gly Ala Pro Val Asn Ile Ser Ser Ser 
    370                 375                 380                 


Asp Leu Xaa Gly Arg Gln Asp Xaa Ser Arg Met Ser Xaa Ser Gln Arg 
385                 390                 395                 400 


Ser Arg Asp Met Ala Ser Leu Arg Leu His Ala Ala Arg Gln Gly Xaa 
                405                 410                 415     


Arg Cys Arg Pro Gln Arg Pro Arg Arg Xaa Tyr 
            420                 425         


<210> 7071
<211> 126
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<400> 7071
Met Glu Leu Arg Val Gly Asn Arg Tyr Arg Leu Gly Arg Lys Ile Gly 
1               5                   10                  15      


Ser Gly Ser Phe Gly Asp Ile Tyr Leu Gly Xaa Asp Ile Ala Ala Gly 
            20                  25                  30          


Glu Glu Val Ala Ile Lys Leu Glu Cys Val Lys Xaa Lys His Pro Gln 
        35                  40                  45              


Leu His Ile Glu Ser Lys Ile Tyr Lys Met Met Gln Gly Gly Val Gly 
    50                  55                  60                  


Ile Pro Xaa Ile Arg Trp Cys Gly Ala Glu Gly Asp Tyr Asn Val Met 
65                  70                  75                  80  


Val Met Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asn Phe Cys 
                85                  90                  95      


Ser Arg Lys Phe Ser Leu Lys Xaa Val Leu Leu Leu Ala Asp Gln Met 
            100                 105                 110         


Asn Asn Pro Glu Glu Met Xaa Trp Ser Leu Trp Ala Xaa Cys 
        115                 120                 125     


<210> 7072
<211> 56
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<400> 7072
Met Glu Leu Arg Val Gly Asn Arg Tyr Arg Leu Gly Arg Lys Ile Gly 
1               5                   10                  15      


Ser Gly Ser Phe Gly Asp Ile Tyr Leu Gly Trp Ser Ala Val Ala Arg 
            20                  25                  30          


Ser Arg Leu Xaa Ala Ser Ser Ala Ser Gln Arg Trp Gly Phe Xaa Val 
        35                  40                  45              


Leu Ala Arg Met Val Ser Ile Ser 
    50                  55      


<210> 7073
<211> 43
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<400> 7073
Met Glu Leu Arg Val Gly Asn Arg Tyr Arg Leu Gly Arg Lys Ile Gly 
1               5                   10                  15      


Ser Gly Ser Phe Gly Asp Ile Tyr Leu Val Glu Met Gly Phe His Arg 
            20                  25                  30          


Val Ser Gln Asp Gly Leu Asn Leu Leu Xaa Leu 
        35                  40              


<210> 7074
<211> 187
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<400> 7074
Met Glu Leu Arg Val Gly Asn Arg Tyr Arg Leu Gly Arg Lys Ile Gly 
1               5                   10                  15      


Ser Gly Ser Phe Gly Asp Ile Tyr Leu Val Gly Ile Pro Xaa Ile Arg 
            20                  25                  30          


Trp Cys Gly Ala Glu Gly Asp Tyr Asn Val Met Val Met Glu Leu Leu 
        35                  40                  45              


Gly Pro Ser Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg Lys Phe Ser 
    50                  55                  60                  


Leu Lys Xaa Val Leu Leu Leu Ala Asp Gln Met Ile Ser Arg Ile Glu 
65                  70                  75                  80  


Tyr Ile His Ser Lys Asn Phe Ile His Arg Asp Val Lys Pro Asp Asn 
                85                  90                  95      


Phe Leu Met Gly Leu Gly Lys Lys Gly Asn Leu Val Tyr Ile Ile Asp 
            100                 105                 110         


Phe Gly Leu Ala Lys Lys Tyr Arg Asp Ala Arg Xaa His Gln His Ile 
        115                 120                 125             


Pro Tyr Arg Glu Asn Lys Asn Leu Xaa Gly Xaa Ala Arg Tyr Ala Ser 
    130                 135                 140                 


Ile Asn Xaa His Leu Gly Ile Glu Gln Ser Arg Arg Asp Asp Leu Glu 
145                 150                 155                 160 


Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Leu Gly Ser Leu Pro Trp 
                165                 170                 175     


Gln Gly Leu Lys Ala Ala Xaa Lys Arg Gln Lys 
            180                 185         


<210> 7075
<211> 120
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 7075
Xaa Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg 
1               5                   10                  15      


Lys Phe Ser Leu Lys Xaa Val Leu Leu Leu Ala Asp Gln Met Ile Ser 
            20                  25                  30          


Arg Ile Glu Tyr Ile His Ser Lys Asn Phe Ile His Arg Asp Val Lys 
        35                  40                  45              


Pro Asp Asn Phe Leu Met Gly Leu Gly Lys Lys Gly Asn Leu Val Tyr 
    50                  55                  60                  


Ile Ile Asp Phe Gly Leu Ala Lys Lys Tyr Arg Asp Ala Arg Xaa His 
65                  70                  75                  80  


Gln His Ile Pro Tyr Arg Glu Asn Lys Asn Leu Xaa Gly Xaa Ala Arg 
                85                  90                  95      


Tyr Ala Ser Ile Asn Xaa His Leu Gly Ile Gly Ala Glu Gly Cys His 
            100                 105                 110         


Gln Glu Xaa Glu Ile Arg Lys Asp 
        115                 120 


<210> 7076
<211> 20
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<400> 7076
Xaa Met Xaa Xaa Cys Ser Xaa Gly Xaa Cys Ser Asn Leu Leu Leu Ser 
1               5                   10                  15      


Arg Leu Lys Ile 
            20  


<210> 7077
<211> 64
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<400> 7077
Xaa Arg Glu Arg Lys Val Ser Met Arg Leu His Arg Gly Ala Pro Val 
1               5                   10                  15      


Asn Ile Ser Ser Ser Asp Leu Xaa Gly Arg Gln Asp Xaa Ser Arg Met 
            20                  25                  30          


Ser Xaa Ser Gln Arg Ser Arg Asp Met Ala Ser Leu Arg Leu His Ala 
        35                  40                  45              


Ala Arg Gln Gly Xaa Arg Cys Arg Pro Gln Arg Pro Arg Arg Xaa Tyr 
    50                  55                  60                  


<210> 7078
<211> 225
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<400> 7078
Met Glu Leu Arg Val Gly Asn Lys Tyr Arg Leu Gly Arg Lys Ile Gly 
1               5                   10                  15      


Ser Gly Ser Phe Gly Asp Ile Tyr Leu Gly Ala Asn Ile Ala Ser Gly 
            20                  25                  30          


Glu Glu Val Ala Ile Lys Leu Glu Cys Val Lys Xaa Lys His Pro Gln 
        35                  40                  45              


Leu His Ile Glu Ser Lys Phe Tyr Lys Met Met Gln Gly Gly Val Gly 
    50                  55                  60                  


Ile Pro Ser Ile Lys Trp Cys Gly Ala Glu Gly Asp Tyr Asn Val Met 
65                  70                  75                  80  


Val Met Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asn Phe Cys 
                85                  90                  95      


Ser Arg Lys Phe Ser Leu Lys Xaa Val Leu Leu Leu Ala Asp Gln Met 
            100                 105                 110         


Ile Ser Arg Ile Glu Tyr Ile His Ser Lys Asn Phe Ile His Arg Asp 
        115                 120                 125             


Val Lys Pro Asp Asn Phe Leu Met Gly Leu Gly Lys Lys Gly Asn Leu 
    130                 135                 140                 


Val Tyr Ile Ile Asp Phe Gly Leu Ala Lys Lys Tyr Arg Asp Ala Arg 
145                 150                 155                 160 


Xaa His Gln His Ile Pro Tyr Arg Glu Asn Lys Asn Leu Xaa Gly Xaa 
                165                 170                 175     


Ala Arg Tyr Ala Ser Ile Asn Xaa His Leu Gly Ile Glu Gln Ser Arg 
            180                 185                 190         


Arg Asp Asp Leu Glu Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Leu 
        195                 200                 205             


Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Xaa Lys Arg Gln Lys 
    210                 215                 220                 


Tyr 
225 


<210> 7079
<211> 311
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<400> 7079
Met Glu Leu Arg Val Gly Asn Lys Tyr Arg Leu Gly Arg Lys Ile Gly 
1               5                   10                  15      


Ser Gly Ser Phe Gly Asp Ile Tyr Leu Gly Ala Asn Ile Ala Ser Gly 
            20                  25                  30          


Glu Glu Val Ala Ile Lys Leu Glu Cys Val Lys Xaa Lys His Pro Gln 
        35                  40                  45              


Leu His Ile Glu Ser Lys Phe Tyr Lys Met Met Gln Gly Gly Val Gly 
    50                  55                  60                  


Ile Pro Ser Ile Lys Trp Cys Gly Ala Glu Gly Asp Tyr Asn Val Met 
65                  70                  75                  80  


Val Met Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asn Phe Cys 
                85                  90                  95      


Ser Arg Lys Phe Ser Leu Lys Xaa Val Leu Leu Leu Ala Asp Gln Met 
            100                 105                 110         


Ile Ser Arg Ile Glu Tyr Ile His Ser Lys Asn Phe Ile His Arg Asp 
        115                 120                 125             


Val Lys Pro Asp Asn Phe Leu Met Gly Leu Gly Lys Lys Gly Asn Leu 
    130                 135                 140                 


Val Tyr Ile Ile Asp Phe Gly Leu Ala Lys Lys Tyr Arg Asp Ala Arg 
145                 150                 155                 160 


Xaa His Gln His Ile Pro Tyr Arg Glu Asn Lys Asn Leu Xaa Gly Xaa 
                165                 170                 175     


Ala Arg Tyr Ala Ser Ile Asn Xaa His Leu Gly Ile Glu Gln Ser Arg 
            180                 185                 190         


Arg Asp Asp Leu Glu Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Leu 
        195                 200                 205             


Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Xaa Lys Arg Gln Lys 
    210                 215                 220                 


Tyr Glu Arg Ile Ser Glu Lys Lys Met Ser Xaa Pro Ile Glu Val Leu 
225                 230                 235                 240 


Cys Lys Gly Tyr Pro Ser Glu Phe Ser Xaa Tyr Leu Asn Phe Cys Arg 
                245                 250                 255     


Ser Leu Arg Phe Asp Asp Lys Pro Asp Tyr Ser Tyr Leu Arg Gln Leu 
            260                 265                 270         


Phe Arg Asn Leu Phe His Arg Gln Gly Phe Ser Tyr Asp Tyr Val Phe 
        275                 280                 285             


Asp Trp Asn Met Leu Lys Phe Xaa Asp Xaa Val Gln Asp Gly Ser His 
    290                 295                 300                 


Trp Pro His Ala Xaa His Phe 
305                 310     


<210> 7080
<211> 336
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<400> 7080
Met Glu Leu Arg Val Gly Asn Lys Tyr Arg Leu Gly Arg Lys Ile Gly 
1               5                   10                  15      


Ser Gly Ser Phe Gly Asp Ile Tyr Leu Gly Ala Asn Ile Ala Ser Gly 
            20                  25                  30          


Glu Glu Val Ala Ile Lys Leu Glu Cys Val Lys Xaa Lys His Pro Gln 
        35                  40                  45              


Leu His Ile Glu Ser Lys Phe Tyr Lys Met Met Gln Gly Gly Val Gly 
    50                  55                  60                  


Ile Pro Ser Ile Lys Trp Cys Gly Ala Glu Gly Asp Tyr Asn Val Met 
65                  70                  75                  80  


Val Met Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asn Phe Cys 
                85                  90                  95      


Ser Arg Lys Phe Ser Leu Lys Xaa Val Leu Leu Leu Ala Asp Gln Met 
            100                 105                 110         


Ile Ser Arg Ile Glu Tyr Ile His Ser Lys Asn Phe Ile His Arg Asp 
        115                 120                 125             


Val Lys Pro Asp Asn Phe Leu Met Gly Leu Gly Lys Lys Gly Asn Leu 
    130                 135                 140                 


Val Tyr Ile Ile Asp Phe Gly Leu Ala Lys Lys Tyr Arg Asp Ala Arg 
145                 150                 155                 160 


Xaa His Gln His Ile Pro Tyr Arg Glu Asn Lys Asn Leu Xaa Gly Xaa 
                165                 170                 175     


Ala Arg Tyr Ala Ser Ile Asn Xaa His Leu Gly Ile Glu Gln Ser Arg 
            180                 185                 190         


Arg Asp Asp Leu Glu Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Leu 
        195                 200                 205             


Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Xaa Lys Arg Gln Lys 
    210                 215                 220                 


Tyr Glu Arg Ile Ser Glu Lys Lys Met Ser Xaa Pro Ile Glu Val Leu 
225                 230                 235                 240 


Cys Lys Gly Tyr Pro Ser Glu Phe Ser Xaa Tyr Leu Asn Phe Cys Arg 
                245                 250                 255     


Ser Leu Arg Phe Asp Asp Lys Pro Asp Tyr Ser Tyr Leu Arg Gln Leu 
            260                 265                 270         


Phe Arg Asn Leu Phe His Arg Gln Gly Phe Ser Tyr Asp Tyr Val Phe 
        275                 280                 285             


Asp Trp Asn Met Leu Lys Phe Ala Arg Ser Xaa Ser Pro Pro Xaa Ala 
    290                 295                 300                 


Ala Gly Leu Xaa Ala Phe Leu Glu Val Pro Leu Glu Ala Gly Pro Gly 
305                 310                 315                 320 


Val Arg Ser Trp Ala Glu Ala Pro Xaa Ala Leu Ser Phe Ala Asn Leu 
                325                 330                 335     


<210> 7081
<211> 416
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<400> 7081
Met Glu Leu Arg Val Gly Asn Lys Tyr Arg Leu Gly Arg Lys Ile Gly 
1               5                   10                  15      


Ser Gly Ser Phe Gly Asp Ile Tyr Leu Gly Ala Asn Ile Ala Ser Gly 
            20                  25                  30          


Glu Glu Val Ala Ile Lys Leu Glu Cys Val Lys Xaa Lys His Pro Gln 
        35                  40                  45              


Leu His Ile Glu Ser Lys Phe Tyr Lys Met Met Gln Gly Gly Val Gly 
    50                  55                  60                  


Ile Pro Ser Ile Lys Trp Cys Gly Ala Glu Gly Asp Tyr Asn Val Met 
65                  70                  75                  80  


Val Met Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asn Phe Cys 
                85                  90                  95      


Ser Arg Lys Phe Ser Leu Lys Xaa Val Leu Leu Leu Ala Asp Gln Met 
            100                 105                 110         


Ile Ser Arg Ile Glu Tyr Ile His Ser Lys Asn Phe Ile His Arg Asp 
        115                 120                 125             


Val Lys Pro Asp Asn Phe Leu Met Gly Leu Gly Lys Lys Gly Asn Leu 
    130                 135                 140                 


Val Tyr Ile Ile Asp Phe Gly Leu Ala Lys Lys Tyr Arg Asp Ala Arg 
145                 150                 155                 160 


Xaa His Gln His Ile Pro Tyr Arg Glu Asn Lys Asn Leu Xaa Gly Xaa 
                165                 170                 175     


Ala Arg Tyr Ala Ser Ile Asn Xaa His Leu Gly Ile Glu Gln Ser Arg 
            180                 185                 190         


Arg Asp Asp Leu Glu Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Leu 
        195                 200                 205             


Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Xaa Lys Arg Gln Lys 
    210                 215                 220                 


Tyr Glu Arg Ile Ser Glu Lys Lys Met Ser Xaa Pro Ile Glu Val Leu 
225                 230                 235                 240 


Cys Lys Gly Tyr Pro Ser Glu Phe Ser Xaa Tyr Leu Asn Phe Cys Arg 
                245                 250                 255     


Ser Leu Arg Phe Asp Asp Lys Pro Asp Tyr Ser Tyr Leu Arg Gln Leu 
            260                 265                 270         


Phe Arg Asn Leu Phe His Arg Gln Gly Phe Ser Tyr Asp Tyr Val Phe 
        275                 280                 285             


Asp Trp Asn Met Leu Lys Phe Gly Ala Ala Arg Asn Pro Glu Asp Val 
    290                 295                 300                 


Asp Arg Glu Arg Arg Glu His Glu Arg Glu Glu Arg Met Gly Gln Leu 
305                 310                 315                 320 


Arg Gly Ser Ala Xaa Arg Ala Leu Pro Pro Gly Pro Pro Xaa Gly Ala 
                325                 330                 335     


Xaa Ala Asn Arg Leu Arg Ser Ala Ala Glu Pro Val Ala Ser Xaa Pro 
            340                 345                 350         


Ala Ser Arg Ile Gln Pro Ala Gly Asn Xaa Ser Pro Arg Ala Ile Ser 
        355                 360                 365             


Arg Val Asp Arg Glu Arg Lys Val Ser Met Arg Leu His Arg Gly Ala 
    370                 375                 380                 


Pro Ala Asn Val Ser Ser Ser Asp Leu Xaa Gly Arg Gln Glu Val Ser 
385                 390                 395                 400 


Arg Ile Pro Ala Ser Gln Xaa Ser Val Pro Phe Asp His Leu Gly Lys 
                405                 410                 415     


<210> 7082
<211> 270
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<400> 7082
Xaa Gly Ile Pro Ser Ile Lys Trp Cys Gly Ala Glu Gly Asp Tyr Asn 
1               5                   10                  15      


Val Met Val Met Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asn 
            20                  25                  30          


Phe Cys Ser Arg Lys Phe Ser Leu Lys Xaa Val Leu Leu Leu Ala Asp 
        35                  40                  45              


Gln Met Ile Ser Arg Ile Glu Tyr Ile His Ser Lys Asn Phe Ile His 
    50                  55                  60                  


Arg Asp Val Lys Pro Asp Asn Phe Leu Met Gly Leu Gly Lys Lys Gly 
65                  70                  75                  80  


Asn Leu Val Tyr Ile Ile Asp Phe Gly Leu Ala Lys Lys Tyr Arg Asp 
                85                  90                  95      


Ala Arg Xaa His Gln His Ile Pro Tyr Arg Glu Asn Lys Asn Leu Xaa 
            100                 105                 110         


Gly Xaa Ala Arg Tyr Ala Ser Ile Asn Xaa His Leu Gly Ile Glu Gln 
        115                 120                 125             


Ser Arg Arg Asp Asp Leu Glu Ser Leu Gly Tyr Val Leu Met Tyr Phe 
    130                 135                 140                 


Asn Leu Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Xaa Lys Arg 
145                 150                 155                 160 


Gln Lys Tyr Glu Arg Ile Ser Glu Lys Lys Met Ser Xaa Pro Ile Glu 
                165                 170                 175     


Val Leu Cys Lys Gly Tyr Pro Ser Glu Phe Ser Xaa Tyr Leu Asn Phe 
            180                 185                 190         


Cys Arg Ser Leu Arg Phe Asp Asp Lys Pro Asp Tyr Ser Tyr Leu Arg 
        195                 200                 205             


Gln Leu Phe Arg Asn Leu Phe His Arg Gln Gly Phe Ser Tyr Asp Tyr 
    210                 215                 220                 


Val Phe Asp Trp Asn Met Leu Lys Phe Gly Ala Ser Ser Ser Gln Ala 
225                 230                 235                 240 


Gln Pro Arg Asp Ser Pro Met Xaa Ala Lys Gly Pro Phe Cys Pro Arg 
                245                 250                 255     


Pro Cys Pro Cys Ala Gly Pro Xaa Tyr Ser Pro Xaa Tyr Trp 
            260                 265                 270 


<210> 7083
<211> 144
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<400> 7083
Xaa Arg Asn Leu Phe His Arg Gln Gly Phe Ser Tyr Asp Tyr Val Phe 
1               5                   10                  15      


Asp Trp Asn Met Leu Lys Phe Gly Ala Ala Arg Asn Pro Glu Asp Val 
            20                  25                  30          


Asp Arg Glu Arg Arg Glu His Glu Arg Glu Glu Arg Met Gly Gln Leu 
        35                  40                  45              


Arg Gly Ser Ala Xaa Arg Ala Leu Pro Pro Gly Pro Pro Xaa Gly Ala 
    50                  55                  60                  


Xaa Ala Asn Arg Leu Arg Ser Ala Ala Glu Pro Val Ala Ser Xaa Pro 
65                  70                  75                  80  


Ala Ser Arg Ile Gln Pro Ala Gly Asn Xaa Ser Pro Arg Ala Ile Ser 
                85                  90                  95      


Arg Val Asp Arg Glu Arg Lys Val Ser Met Arg Leu His Arg Gly Ala 
            100                 105                 110         


Pro Ala Asn Val Ser Ser Ser Asp Leu Xaa Gly Arg Gln Glu Val Ser 
        115                 120                 125             


Arg Ile Pro Ala Ser Gln Xaa Ser Val Pro Phe Asp His Leu Gly Lys 
    130                 135                 140                 


<210> 7084
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 7084
Xaa Arg Asn Pro Glu Asp Val Asp Arg Glu Arg Arg Glu His Glu Arg 
1               5                   10                  15      


Glu Glu Arg Met Gly Gln Leu Arg Gly Ser Ala Xaa Arg Ala Leu Pro 
            20                  25                  30          


Pro Gly Pro Pro Xaa Gly Ala Xaa Ala Asn Arg Leu Arg Ser Ala Ala 
        35                  40                  45              


Glu Pro Val Ala Ser Xaa Pro Ala Ser Arg Ile Gln Pro Ala Gly Asn 
    50                  55                  60                  


Xaa Ser Pro Arg Ala Ile Ser Arg Val Asp Arg Glu Arg Lys Val Ser 
65                  70                  75                  80  


Met Arg Leu His Arg Gly Ala Pro Ala Asn Val Ser Ser Ser Asp Leu 
                85                  90                  95      


Xaa Gly Arg Gln Glu Val Ser Arg Ile Pro Ala Ser Gln Xaa Ser Val 
            100                 105                 110         


Pro Phe Asp His Leu Gly Lys 
        115                 


<210> 7085
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 7085
Xaa Arg Pro Ala Xaa Leu Pro Ser Xaa Arg Xaa Trp Ala Leu Ser Lys 
1               5                   10                  15      


Ala Val Glu Met Xaa Trp Arg Ala Trp Ala Xaa Cys Ser Cys Xaa Ser 
            20                  25                  30          


Xaa Trp Ala Pro Cys Pro Gly Arg Gly Ser Lys Gln Pro Pro Ser Ala 
        35                  40                  45              


Arg Ser Met Asn Gly Ser Ala Arg Arg Arg Cys Gln Arg Pro Ser Arg 
    50                  55                  60                  


Ser Ser Ala Lys Ala Ile Pro Pro Asn Ser Gln His Xaa Ser Xaa Ser 
65                  70                  75                  80  


Ala Ala Pro Cys Gly Leu Xaa Xaa Ser Pro Xaa Xaa Leu Xaa Tyr Val 
                85                  90                  95      


Ser Ser Ser Ala Xaa Ser Ser Xaa Gly Arg Ala Ser Pro Met Xaa Xaa 
            100                 105                 110         


Ser Leu Xaa Gly Xaa Cys 
        115             


<210> 7086
<211> 91
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<400> 7086
Xaa Ser Cys Xaa Ser Xaa Trp Ala Pro Cys Pro Gly Arg Gly Ser Lys 
1               5                   10                  15      


Gln Pro Pro Ser Ala Arg Ser Met Asn Gly Ser Ala Arg Arg Arg Cys 
            20                  25                  30          


Gln Arg Pro Ser Arg Ser Ser Ala Lys Ala Ile Pro Pro Asn Ser Gln 
        35                  40                  45              


His Xaa Ser Xaa Ser Ala Ala Pro Cys Gly Leu Xaa Xaa Ser Pro Xaa 
    50                  55                  60                  


Xaa Leu Xaa Tyr Val Ser Ser Ser Ala Xaa Ser Ser Xaa Gly Arg Ala 
65                  70                  75                  80  


Ser Pro Met Xaa Xaa Ser Leu Xaa Gly Xaa Cys 
                85                  90      


<210> 7087
<211> 173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<400> 7087
Ala Xaa Tyr Leu Arg Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro 
1               5                   10                  15      


Asp Tyr Glu Tyr Leu Arg Xaa Leu Phe Xaa Asp Leu Phe Glu Lys Lys 
            20                  25                  30          


Gly Tyr Xaa Phe Asp Tyr Ala Tyr Asp Trp Val Gly Arg Pro Ile Pro 
        35                  40                  45              


Xaa Pro Val Gly Ser Val His Val Asp Ser Gly Ala Ser Ala Ile Xaa 
    50                  55                  60                  


Arg Glu Ser His Xaa His Arg Asp Arg Pro Ser Gln Gln Gln Pro Leu 
65                  70                  75                  80  


Arg Asn Gln Asn Val Ser Ser Glu Arg Arg Gly Glu Trp Glu Ile Gln 
                85                  90                  95      


Pro Ser Arg Gln Xaa Asn Xaa Ser Tyr Leu Xaa Ser His Leu Ala Ala 
            100                 105                 110         


Asp Arg His Gly Gly Ser Val Gln Pro Arg Ser Leu Xaa Ser Arg Val 
        115                 120                 125             


Phe Cys Pro Ala Val Arg Pro Leu Phe Pro Leu Pro Ser Xaa His Ile 
    130                 135                 140                 


Asn Arg Asn Asn Val Leu Glu Met Lys Pro Gly Gly Arg Ser Ser Tyr 
145                 150                 155                 160 


Xaa Cys Lys Arg Ser Leu Ile Gly Ser Xaa Leu Xaa Arg 
                165                 170             


<210> 7088
<211> 67
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<400> 7088
Asp Leu Phe Glu Lys Lys Gly Tyr Xaa Phe Asp Tyr Ala Tyr Asp Trp 
1               5                   10                  15      


Val Gly Arg Pro Ile Pro Xaa Pro Val Gly Ser Val His Val Asp Ser 
            20                  25                  30          


Gly Ala Ser Ala Ile Xaa Arg Glu Ser His Xaa His Arg Asp Arg Pro 
        35                  40                  45              


Ser Gln Gln Gln Pro Leu Arg Asn Gln Val Asp Cys Ser Leu Ala Asn 
    50                  55                  60                  


Ser Pro Ile 
65          


<210> 7089
<211> 158
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(145)
<223> Selenocysteine

<400> 7089
Phe Phe Glu Lys Pro Asp Tyr Glu Tyr Leu Arg Xaa Leu Phe Xaa Asp 
1               5                   10                  15      


Leu Phe Glu Lys Lys Gly Tyr Xaa Phe Asp Tyr Ala Tyr Asp Trp Val 
            20                  25                  30          


Gly Arg Pro Ile Pro Xaa Pro Val Gly Ser Val His Val Asp Ser Gly 
        35                  40                  45              


Ala Ser Ala Ile Xaa Arg Glu Ser His Xaa His Arg Asp Arg Pro Ser 
    50                  55                  60                  


Gln Gln Gln Pro Leu Arg Asn Gln Val Val Ser Ser Xaa Asn Gly Glu 
65                  70                  75                  80  


Leu Asn Val Asp Asp Pro Xaa Gly Ala His Ser Asn Ala Pro Ile Xaa 
                85                  90                  95      


Ala His Ala Glu Val Glu Val Val Glu Glu Ala Lys Tyr Val His Leu 
            100                 105                 110         


Ser Arg Gly Leu Leu Ser His Gly Leu Lys Asn Leu Phe Cys Leu Phe 
        115                 120                 125             


Leu Ser Val Cys Cys Ser Ser Gln Xaa Gly Phe Leu Met Leu Val Xaa 
    130                 135                 140                 


Xaa Ala Phe Phe Leu Asn Cys Phe Asn Phe Cys Met Val Pro 
145                 150                 155             


<210> 7090
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<400> 7090
Met Asp His Pro Ser Arg Glu Lys Asp Glu Arg Gln Arg Xaa Xaa Lys 
1               5                   10                  15      


Pro Met Ala Gln Arg Ser Ala His Cys Ser Arg Pro Ser Gly Ser Ser 
            20                  25                  30          


Ser Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val Gly Lys 
        35                  40                  45              


Lys Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys Asn Leu 
    50                  55                  60                  


Tyr Xaa Asn Glu Tyr Val Ala Ile Lys Leu Glu Pro Ile Lys Ser Arg 
65                  70                  75                  80  


Ala Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln Leu Gly Ser 
                85                  90                  95      


Ala Gly Glu Gly Leu Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly Lys 
            100                 105                 110         


Tyr Asn Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu 
        115                 120                 125             


Phe Asp Leu Cys Asp Arg Xaa Phe Xaa Leu 
    130                 135             


<210> 7091
<211> 183
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<400> 7091
Met Asp His Pro Ser Arg Glu Lys Asp Glu Arg Gln Arg Xaa Xaa Lys 
1               5                   10                  15      


Pro Met Ala Gln Arg Ser Ala His Cys Ser Arg Pro Ser Gly Ser Ser 
            20                  25                  30          


Ser Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val Gly Lys 
        35                  40                  45              


Lys Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys Asn Leu 
    50                  55                  60                  


Tyr Xaa Asn Glu Tyr Val Ala Ile Lys Leu Glu Pro Ile Lys Ser Arg 
65                  70                  75                  80  


Ala Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln Leu Gly Ser 
                85                  90                  95      


Ala Gly Glu Gly Leu Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly Lys 
            100                 105                 110         


Tyr Asn Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu 
        115                 120                 125             


Phe Asp Leu Cys Asp Arg Xaa Phe Xaa Leu Lys Xaa Val Leu Met Ile 
    130                 135                 140                 


Ala Ile Gln Leu Leu Ser Arg Met Glu Tyr Val His Ser Lys Asn Leu 
145                 150                 155                 160 


Ile Tyr Arg Asp Val Lys Pro Glu Asn Phe Leu Ile Gly Arg Gln Gly 
                165                 170                 175     


Asn Lys Lys Glu His Val Ile 
            180             


<210> 7092
<211> 393
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<400> 7092
Met Asp His Pro Ser Arg Glu Lys Asp Glu Arg Gln Arg Xaa Xaa Lys 
1               5                   10                  15      


Pro Met Ala Gln Arg Ser Ala His Cys Ser Arg Pro Ser Gly Ser Ser 
            20                  25                  30          


Ser Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val Gly Lys 
        35                  40                  45              


Lys Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys Asn Leu 
    50                  55                  60                  


Tyr Xaa Asn Glu Tyr Val Ala Ile Lys Leu Glu Pro Ile Lys Ser Arg 
65                  70                  75                  80  


Ala Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln Leu Gly Ser 
                85                  90                  95      


Ala Gly Glu Gly Leu Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly Lys 
            100                 105                 110         


Tyr Asn Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu 
        115                 120                 125             


Phe Asp Leu Cys Asp Arg Xaa Phe Xaa Leu Lys Xaa Val Leu Met Ile 
    130                 135                 140                 


Ala Ile Gln Leu Leu Ser Arg Met Glu Tyr Val His Ser Lys Asn Leu 
145                 150                 155                 160 


Ile Tyr Arg Asp Val Lys Pro Glu Asn Phe Leu Ile Gly Arg Gln Gly 
                165                 170                 175     


Asn Lys Lys Glu His Val Ile His Ile Ile Asp Phe Gly Leu Ala Lys 
            180                 185                 190         


Glu Tyr Ile Asp Pro Glu Xaa Lys Lys His Ile Pro Tyr Arg Glu His 
        195                 200                 205             


Lys Ser Leu Xaa Gly Xaa Ala Arg Tyr Met Ser Ile Asn Xaa His Leu 
    210                 215                 220                 


Gly Lys Glu Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu Gly His Met 
225                 230                 235                 240 


Phe Met Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala 
                245                 250                 255     


Asp Xaa Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Xaa Lys Arg Asn 
            260                 265                 270         


Xaa Pro Ile Glu Ala Leu Cys Glu Asn Phe Pro Glu Glu Met Ala Xaa 
        275                 280                 285             


Tyr Leu Arg Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro Asp Tyr 
    290                 295                 300                 


Glu Tyr Leu Arg Xaa Leu Phe Xaa Asp Leu Phe Glu Lys Lys Gly Tyr 
305                 310                 315                 320 


Xaa Phe Asp Tyr Ala Tyr Asp Trp Val Gly Arg Pro Ile Pro Xaa Pro 
                325                 330                 335     


Val Gly Ser Val His Val Asp Ser Gly Ala Ser Ala Ile Xaa Arg Glu 
            340                 345                 350         


Ser His Xaa His Arg Asp Arg Pro Ser Gln Gln Gln Pro Leu Arg Asn 
        355                 360                 365             


Gln Ser Leu Arg Xaa Val Xaa Ala Glu His Tyr Asp Val Asn Asn Ser 
    370                 375                 380                 


Ala Ile Trp His Arg Gly Arg Gly Xaa 
385                 390             


<210> 7093
<211> 422
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<400> 7093
Met Asp His Pro Ser Arg Glu Lys Asp Glu Arg Gln Arg Xaa Xaa Lys 
1               5                   10                  15      


Pro Met Ala Gln Arg Ser Ala His Cys Ser Arg Pro Ser Gly Ser Ser 
            20                  25                  30          


Ser Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val Gly Lys 
        35                  40                  45              


Lys Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys Asn Leu 
    50                  55                  60                  


Tyr Xaa Asn Glu Tyr Val Ala Ile Lys Leu Glu Pro Ile Lys Ser Arg 
65                  70                  75                  80  


Ala Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln Leu Gly Ser 
                85                  90                  95      


Ala Gly Glu Gly Leu Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly Lys 
            100                 105                 110         


Tyr Asn Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu 
        115                 120                 125             


Phe Asp Leu Cys Asp Arg Xaa Phe Xaa Leu Lys Xaa Val Leu Met Ile 
    130                 135                 140                 


Ala Ile Gln Leu Leu Ser Arg Met Glu Tyr Val His Ser Lys Asn Leu 
145                 150                 155                 160 


Ile Tyr Arg Asp Val Lys Pro Glu Asn Phe Leu Ile Gly Arg Gln Gly 
                165                 170                 175     


Asn Lys Lys Glu His Val Ile His Ile Ile Asp Phe Gly Leu Ala Lys 
            180                 185                 190         


Glu Tyr Ile Asp Pro Glu Xaa Lys Lys His Ile Pro Tyr Arg Glu His 
        195                 200                 205             


Lys Ser Leu Xaa Gly Xaa Ala Arg Tyr Met Ser Ile Asn Xaa His Leu 
    210                 215                 220                 


Gly Lys Glu Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu Gly His Met 
225                 230                 235                 240 


Phe Met Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala 
                245                 250                 255     


Asp Xaa Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Xaa Lys Arg Asn 
            260                 265                 270         


Xaa Pro Ile Glu Ala Leu Cys Glu Asn Phe Pro Glu Glu Met Ala Xaa 
        275                 280                 285             


Tyr Leu Arg Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro Asp Tyr 
    290                 295                 300                 


Glu Tyr Leu Arg Xaa Leu Phe Xaa Asp Leu Phe Glu Lys Lys Gly Tyr 
305                 310                 315                 320 


Xaa Phe Asp Tyr Ala Tyr Asp Trp Val Gly Arg Pro Ile Pro Xaa Pro 
                325                 330                 335     


Val Gly Ser Val His Val Asp Ser Gly Ala Ser Ala Ile Xaa Arg Glu 
            340                 345                 350         


Ser His Xaa His Arg Asp Arg Pro Ser Gln Gln Gln Pro Leu Arg Asn 
        355                 360                 365             


Gln Val Val Ser Ser Xaa Asn Gly Glu Leu Asn Val Asp Asp Pro Xaa 
    370                 375                 380                 


Gly Ala His Ser Asn Ala Pro Ile Xaa Ala His Ala Glu Val Glu Val 
385                 390                 395                 400 


Val Glu Glu Ala Lys Cys Cys Cys Phe Phe Lys Arg Lys Arg Lys Lys 
                405                 410                 415     


Xaa Ala Gln Arg His Lys 
            420         


<210> 7094
<211> 422
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<400> 7094
Met Asp His Pro Ser Arg Glu Lys Asp Glu Arg Gln Arg Xaa Xaa Lys 
1               5                   10                  15      


Pro Met Ala Gln Arg Ser Ala His Cys Ser Arg Pro Ser Gly Ser Ser 
            20                  25                  30          


Ser Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val Gly Lys 
        35                  40                  45              


Lys Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys Asn Leu 
    50                  55                  60                  


Tyr Xaa Asn Glu Tyr Val Ala Ile Lys Leu Glu Pro Ile Lys Ser Arg 
65                  70                  75                  80  


Ala Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln Leu Gly Ser 
                85                  90                  95      


Ala Gly Glu Gly Leu Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly Lys 
            100                 105                 110         


Tyr Asn Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu 
        115                 120                 125             


Phe Asp Leu Cys Asp Arg Xaa Phe Xaa Leu Lys Xaa Val Leu Met Ile 
    130                 135                 140                 


Ala Ile Gln Leu Leu Ser Arg Met Glu Tyr Val His Ser Lys Asn Leu 
145                 150                 155                 160 


Ile Tyr Arg Asp Val Lys Pro Glu Asn Phe Leu Ile Gly Arg Gln Gly 
                165                 170                 175     


Asn Lys Lys Glu His Val Ile His Ile Ile Asp Phe Gly Leu Ala Lys 
            180                 185                 190         


Glu Tyr Ile Asp Pro Glu Xaa Lys Lys His Ile Pro Tyr Arg Glu His 
        195                 200                 205             


Lys Ser Leu Xaa Gly Xaa Ala Arg Tyr Met Ser Ile Asn Xaa His Leu 
    210                 215                 220                 


Gly Lys Glu Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu Gly His Met 
225                 230                 235                 240 


Phe Met Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala 
                245                 250                 255     


Asp Xaa Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Xaa Lys Arg Asn 
            260                 265                 270         


Xaa Pro Ile Glu Ala Leu Cys Glu Asn Phe Pro Glu Glu Met Ala Xaa 
        275                 280                 285             


Tyr Leu Arg Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro Asp Tyr 
    290                 295                 300                 


Glu Tyr Leu Arg Xaa Leu Phe Xaa Asp Leu Phe Glu Lys Lys Gly Tyr 
305                 310                 315                 320 


Xaa Phe Asp Tyr Ala Tyr Asp Trp Val Gly Arg Pro Ile Pro Xaa Pro 
                325                 330                 335     


Val Gly Ser Val His Val Asp Ser Gly Ala Ser Ala Ile Xaa Arg Glu 
            340                 345                 350         


Ser His Xaa His Arg Asp Arg Pro Ser Gln Gln Gln Pro Leu Arg Asn 
        355                 360                 365             


Gln Pro Arg Ser Leu Xaa Ser Arg Val Phe Cys Pro Ala Val Arg Pro 
    370                 375                 380                 


Leu Phe Pro Leu Pro Ser Xaa His Ile Asn Arg Asn Asn Val Leu Glu 
385                 390                 395                 400 


Met Lys Pro Gly Gly Arg Ser Ser Tyr Xaa Cys Lys Arg Ser Leu Ile 
                405                 410                 415     


Gly Ser Xaa Leu Xaa Arg 
            420         


<210> 7095
<211> 430
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<400> 7095
Met Asp His Pro Ser Arg Glu Lys Asp Glu Arg Gln Arg Xaa Xaa Lys 
1               5                   10                  15      


Pro Met Ala Gln Arg Ser Ala His Cys Ser Arg Pro Ser Gly Ser Ser 
            20                  25                  30          


Ser Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val Gly Lys 
        35                  40                  45              


Lys Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys Asn Leu 
    50                  55                  60                  


Tyr Xaa Asn Glu Tyr Val Ala Ile Lys Leu Glu Pro Ile Lys Ser Arg 
65                  70                  75                  80  


Ala Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln Leu Gly Ser 
                85                  90                  95      


Ala Gly Glu Gly Leu Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly Lys 
            100                 105                 110         


Tyr Asn Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu 
        115                 120                 125             


Phe Asp Leu Cys Asp Arg Xaa Phe Xaa Leu Lys Xaa Val Leu Met Ile 
    130                 135                 140                 


Ala Ile Gln Leu Leu Ser Arg Met Glu Tyr Val His Ser Lys Asn Leu 
145                 150                 155                 160 


Ile Tyr Arg Asp Val Lys Pro Glu Asn Phe Leu Ile Gly Arg Gln Gly 
                165                 170                 175     


Asn Lys Lys Glu His Val Ile His Ile Ile Asp Phe Gly Leu Ala Lys 
            180                 185                 190         


Glu Tyr Ile Asp Pro Glu Xaa Lys Lys His Ile Pro Tyr Arg Glu His 
        195                 200                 205             


Lys Ser Leu Xaa Gly Xaa Ala Arg Tyr Met Ser Ile Asn Xaa His Leu 
    210                 215                 220                 


Gly Lys Glu Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu Gly His Met 
225                 230                 235                 240 


Phe Met Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala 
                245                 250                 255     


Asp Xaa Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Xaa Lys Arg Asn 
            260                 265                 270         


Xaa Pro Ile Glu Ala Leu Cys Glu Asn Phe Pro Glu Glu Met Ala Xaa 
        275                 280                 285             


Tyr Leu Arg Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro Asp Tyr 
    290                 295                 300                 


Glu Tyr Leu Arg Xaa Leu Phe Xaa Asp Leu Phe Glu Lys Lys Gly Tyr 
305                 310                 315                 320 


Xaa Phe Asp Tyr Ala Tyr Asp Trp Val Gly Arg Pro Ile Pro Xaa Pro 
                325                 330                 335     


Val Gly Ser Val His Val Asp Ser Gly Ala Ser Ala Ile Xaa Arg Glu 
            340                 345                 350         


Ser His Xaa His Arg Asp Arg Pro Ser Gln Gln Gln Pro Leu Arg Asn 
        355                 360                 365             


Gln Val Val Ser Ser Xaa Asn Gly Glu Leu Asn Val Asp Asp Pro Xaa 
    370                 375                 380                 


Gly Ala His Ser Asn Ala Pro Ile Xaa Ala His Ala Glu Val Glu Val 
385                 390                 395                 400 


Val Glu Glu Ala Asn Cys Leu Lys Met Leu Asn Leu Trp Cys Cys Cys 
                405                 410                 415     


Phe Phe Lys Arg Lys Arg Lys Lys Xaa Ala Gln Arg His Lys 
            420                 425                 430 


<210> 7096
<211> 438
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<400> 7096
Met Asp His Pro Ser Arg Glu Lys Asp Glu Arg Gln Arg Xaa Xaa Lys 
1               5                   10                  15      


Pro Met Ala Gln Arg Ser Ala His Cys Ser Arg Pro Ser Gly Ser Ser 
            20                  25                  30          


Ser Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val Gly Lys 
        35                  40                  45              


Lys Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys Asn Leu 
    50                  55                  60                  


Tyr Xaa Asn Glu Tyr Val Ala Ile Lys Leu Glu Pro Ile Lys Ser Arg 
65                  70                  75                  80  


Ala Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln Leu Gly Ser 
                85                  90                  95      


Ala Gly Glu Gly Leu Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly Lys 
            100                 105                 110         


Tyr Asn Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu 
        115                 120                 125             


Phe Asp Leu Cys Asp Arg Xaa Phe Xaa Leu Lys Xaa Val Leu Met Ile 
    130                 135                 140                 


Ala Ile Gln Leu Leu Ser Arg Met Glu Tyr Val His Ser Lys Asn Leu 
145                 150                 155                 160 


Ile Tyr Arg Asp Val Lys Pro Glu Asn Phe Leu Ile Gly Arg Gln Gly 
                165                 170                 175     


Asn Lys Lys Glu His Val Ile His Ile Ile Asp Phe Gly Leu Ala Lys 
            180                 185                 190         


Glu Tyr Ile Asp Pro Glu Xaa Lys Lys His Ile Pro Tyr Arg Glu His 
        195                 200                 205             


Lys Ser Leu Xaa Gly Xaa Ala Arg Tyr Met Ser Ile Asn Xaa His Leu 
    210                 215                 220                 


Gly Lys Glu Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu Gly His Met 
225                 230                 235                 240 


Phe Met Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala 
                245                 250                 255     


Asp Xaa Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Xaa Lys Arg Asn 
            260                 265                 270         


Xaa Pro Ile Glu Ala Leu Cys Glu Asn Phe Pro Glu Glu Met Ala Xaa 
        275                 280                 285             


Tyr Leu Arg Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro Asp Tyr 
    290                 295                 300                 


Glu Tyr Leu Arg Xaa Leu Phe Xaa Asp Leu Phe Glu Lys Lys Gly Tyr 
305                 310                 315                 320 


Xaa Phe Asp Tyr Ala Tyr Asp Trp Val Gly Arg Pro Ile Pro Xaa Pro 
                325                 330                 335     


Val Gly Ser Val His Val Asp Ser Gly Ala Ser Ala Ile Xaa Arg Glu 
            340                 345                 350         


Ser His Xaa His Arg Asp Arg Pro Ser Gln Gln Gln Pro Leu Arg Asn 
        355                 360                 365             


Gln Val Val Ser Ser Xaa Asn Gly Glu Leu Asn Val Asp Asp Pro Xaa 
    370                 375                 380                 


Gly Ala His Ser Asn Ala Pro Ile Xaa Ala His Ala Glu Val Glu Val 
385                 390                 395                 400 


Val Glu Glu Ala Lys Cys Ile Met Phe His Lys Pro Trp His Trp Ser 
                405                 410                 415     


Gln Ser Ser Ala Val Lys Met Lys Phe Val Val Phe Leu Asn Met Asn 
            420                 425                 430         


Val Asn Phe Lys Cys Ile 
        435             


<210> 7097
<211> 459
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<400> 7097
Met Asp His Pro Ser Arg Glu Lys Asp Glu Arg Gln Arg Xaa Xaa Lys 
1               5                   10                  15      


Pro Met Ala Gln Arg Ser Ala His Cys Ser Arg Pro Ser Gly Ser Ser 
            20                  25                  30          


Ser Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val Gly Lys 
        35                  40                  45              


Lys Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys Asn Leu 
    50                  55                  60                  


Tyr Xaa Asn Glu Tyr Val Ala Ile Lys Leu Glu Pro Ile Lys Ser Arg 
65                  70                  75                  80  


Ala Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln Leu Gly Ser 
                85                  90                  95      


Ala Gly Glu Gly Leu Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly Lys 
            100                 105                 110         


Tyr Asn Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu 
        115                 120                 125             


Phe Asp Leu Cys Asp Arg Xaa Phe Xaa Leu Lys Xaa Val Leu Met Ile 
    130                 135                 140                 


Ala Ile Gln Leu Leu Ser Arg Met Glu Tyr Val His Ser Lys Asn Leu 
145                 150                 155                 160 


Ile Tyr Arg Asp Val Lys Pro Glu Asn Phe Leu Ile Gly Arg Gln Gly 
                165                 170                 175     


Asn Lys Lys Glu His Val Ile His Ile Ile Asp Phe Gly Leu Ala Lys 
            180                 185                 190         


Glu Tyr Ile Asp Pro Glu Xaa Lys Lys His Ile Pro Tyr Arg Glu His 
        195                 200                 205             


Lys Ser Leu Xaa Gly Xaa Ala Arg Tyr Met Ser Ile Asn Xaa His Leu 
    210                 215                 220                 


Gly Lys Glu Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu Gly His Met 
225                 230                 235                 240 


Phe Met Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala 
                245                 250                 255     


Asp Xaa Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Xaa Lys Arg Asn 
            260                 265                 270         


Xaa Pro Ile Glu Ala Leu Cys Glu Asn Phe Pro Glu Glu Met Ala Xaa 
        275                 280                 285             


Tyr Leu Arg Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro Asp Tyr 
    290                 295                 300                 


Glu Tyr Leu Arg Xaa Leu Phe Xaa Asp Leu Phe Glu Lys Lys Gly Tyr 
305                 310                 315                 320 


Xaa Phe Asp Tyr Ala Tyr Asp Trp Val Gly Arg Pro Ile Pro Xaa Pro 
                325                 330                 335     


Val Gly Ser Val His Val Asp Ser Gly Ala Ser Ala Ile Xaa Arg Glu 
            340                 345                 350         


Ser His Xaa His Arg Asp Arg Pro Ser Gln Gln Gln Pro Leu Arg Asn 
        355                 360                 365             


Gln Asn Val Ser Ser Glu Arg Arg Gly Glu Trp Glu Ile Gln Pro Ser 
    370                 375                 380                 


Arg Gln Xaa Asn Xaa Ser Tyr Leu Xaa Ser His Leu Ala Ala Asp Arg 
385                 390                 395                 400 


His Gly Gly Ser Val Gln Val Val Ser Ser Xaa Asn Gly Glu Leu Asn 
                405                 410                 415     


Val Asp Asp Pro Xaa Gly Ala His Ser Asn Ala Pro Ile Xaa Ala His 
            420                 425                 430         


Ala Glu Val Glu Val Val Glu Glu Ala Lys Cys Cys Cys Phe Phe Lys 
        435                 440                 445             


Arg Lys Arg Lys Lys Xaa Ala Gln Arg His Lys 
    450                 455                 


<210> 7098
<211> 475
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<400> 7098
Met Asp His Pro Ser Arg Glu Lys Asp Glu Arg Gln Arg Xaa Xaa Lys 
1               5                   10                  15      


Pro Met Ala Gln Arg Ser Ala His Cys Ser Arg Pro Ser Gly Ser Ser 
            20                  25                  30          


Ser Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val Gly Lys 
        35                  40                  45              


Lys Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys Asn Leu 
    50                  55                  60                  


Tyr Xaa Asn Glu Tyr Val Ala Ile Lys Leu Glu Pro Ile Lys Ser Arg 
65                  70                  75                  80  


Ala Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln Leu Gly Ser 
                85                  90                  95      


Ala Gly Glu Gly Leu Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly Lys 
            100                 105                 110         


Tyr Asn Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu 
        115                 120                 125             


Phe Asp Leu Cys Asp Arg Xaa Phe Xaa Leu Lys Xaa Val Leu Met Ile 
    130                 135                 140                 


Ala Ile Gln Leu Leu Ser Arg Met Glu Tyr Val His Ser Lys Asn Leu 
145                 150                 155                 160 


Ile Tyr Arg Asp Val Lys Pro Glu Asn Phe Leu Ile Gly Arg Gln Gly 
                165                 170                 175     


Asn Lys Lys Glu His Val Ile His Ile Ile Asp Phe Gly Leu Ala Lys 
            180                 185                 190         


Glu Tyr Ile Asp Pro Glu Xaa Lys Lys His Ile Pro Tyr Arg Glu His 
        195                 200                 205             


Lys Ser Leu Xaa Gly Xaa Ala Arg Tyr Met Ser Ile Asn Xaa His Leu 
    210                 215                 220                 


Gly Lys Glu Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu Gly His Met 
225                 230                 235                 240 


Phe Met Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala 
                245                 250                 255     


Asp Xaa Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Xaa Lys Arg Asn 
            260                 265                 270         


Xaa Pro Ile Glu Ala Leu Cys Glu Asn Phe Pro Glu Glu Met Ala Xaa 
        275                 280                 285             


Tyr Leu Arg Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro Asp Tyr 
    290                 295                 300                 


Glu Tyr Leu Arg Xaa Leu Phe Xaa Asp Leu Phe Glu Lys Lys Gly Tyr 
305                 310                 315                 320 


Xaa Phe Asp Tyr Ala Tyr Asp Trp Val Gly Arg Pro Ile Pro Xaa Pro 
                325                 330                 335     


Val Gly Ser Val His Val Asp Ser Gly Ala Ser Ala Ile Xaa Arg Glu 
            340                 345                 350         


Ser His Xaa His Arg Asp Arg Pro Ser Gln Gln Gln Pro Leu Arg Asn 
        355                 360                 365             


Gln Asn Val Ser Ser Glu Arg Arg Gly Glu Trp Glu Ile Gln Pro Ser 
    370                 375                 380                 


Arg Gln Xaa Asn Xaa Ser Tyr Leu Xaa Ser His Leu Ala Ala Asp Arg 
385                 390                 395                 400 


His Gly Gly Ser Val Gln Val Val Ser Ser Xaa Asn Gly Glu Leu Asn 
                405                 410                 415     


Val Asp Asp Pro Xaa Gly Ala His Ser Asn Ala Pro Ile Xaa Ala His 
            420                 425                 430         


Ala Glu Val Glu Val Val Glu Glu Ala Lys Cys Ile Met Phe His Lys 
        435                 440                 445             


Pro Trp His Trp Ser Gln Ser Ser Ala Val Lys Met Lys Phe Val Val 
    450                 455                 460                 


Phe Leu Asn Met Asn Val Asn Phe Lys Cys Ile 
465                 470                 475 


<210> 7099
<211> 114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 7099
Met Asp His Pro Ser Arg Glu Lys Asp Glu Arg Gln Arg Xaa Xaa Lys 
1               5                   10                  15      


Pro Met Ala Gln Arg Ser Ala His Cys Ser Arg Pro Ser Gly Ser Ser 
            20                  25                  30          


Ser Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val Gly Lys 
        35                  40                  45              


Lys Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys Asn Leu 
    50                  55                  60                  


Tyr Xaa Asn Glu Tyr Val Ala Ile Lys Leu Val Lys Val Ser His Arg 
65                  70                  75                  80  


Cys Ile Xaa Leu Asp His Val Gly Asn Ile Met Pro Trp Cys Trp Ser 
                85                  90                  95      


Ser Leu Ala Leu Ala Trp Arg Xaa Cys Leu Xaa Ser Val Xaa Glu His 
            100                 105                 110         


Leu Leu 
        


<210> 7100
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<400> 7100
Met Asp His Pro Ser Arg Glu Lys Asp Glu Arg Gln Arg Xaa Xaa Lys 
1               5                   10                  15      


Pro Met Ala Gln Arg Ser Ala His Cys Ser Arg Pro Ser Gly Ser Ser 
            20                  25                  30          


Ser Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val Gly Lys 
        35                  40                  45              


Lys Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Xaa Asn Lys 
    50                  55                  60                  


Ile Xaa Cys Ser Xaa Ala Ser Phe Arg Val Gln Ile Leu 
65                  70                  75          


<210> 7101
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<400> 7101
Gln Lys Ile Gly Asp Xaa Lys Arg Asn Xaa Pro Ile Glu Ala Leu Cys 
1               5                   10                  15      


Glu Asn Phe Pro Glu Glu Met Ala Xaa Tyr Leu Arg Tyr Val Arg Arg 
            20                  25                  30          


Leu Asp Phe Phe Glu Lys Pro Asp Tyr Glu Tyr Leu Arg Xaa Leu Phe 
        35                  40                  45              


Xaa Asp Leu Phe Glu Lys Lys Gly Tyr Xaa Phe Asp Tyr Ala Tyr Asp 
    50                  55                  60                  


Trp Val Gly Arg Pro Ile Pro Xaa Pro Val Gly Ser Val His Val Asp 
65                  70                  75                  80  


Ser Gly Ala Ser Ala Ile Xaa Arg Glu Ser His Xaa His Arg Asp Arg 
                85                  90                  95      


Pro Ser Gln Gln Gln Pro Leu Arg Asn Gln Asn Val Ser Ser Glu Arg 
            100                 105                 110         


Arg Gly Glu Trp Glu Ile Gln Pro Ser Arg Gln Xaa Asn Xaa Ser Tyr 
        115                 120                 125             


Leu Xaa Ser His Leu Ala Ala Asp Arg His Gly Gly Ser Val Gln Val 
    130                 135                 140                 


Val Ser Ser Xaa Asn Gly Glu Leu Asn Val Asp Asp Pro Xaa Gly Ala 
145                 150                 155                 160 


His Ser Asn Ala Pro Ile Xaa Ala His Ala Glu Val Glu Val Val Glu 
                165                 170                 175     


Glu Ala Asn Cys Leu Lys Met Leu Asn Leu Trp Cys Cys Cys Phe Phe 
            180                 185                 190         


Lys Arg Lys Arg Lys Lys Xaa Ala Gln Arg His Lys 
        195                 200                 


<210> 7102
<211> 36
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<400> 7102
Xaa Gly Ser Val His Val Asp Ser Gly Ala Ser Ala Ile Xaa Arg Glu 
1               5                   10                  15      


Ser His Xaa His Arg Asp Arg Pro Ser Gln Gln Gln Pro Leu Arg Asn 
            20                  25                  30          


Gln Ser Xaa Val 
        35      


<210> 7103
<211> 114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<400> 7103
Phe Met Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala 
1               5                   10                  15      


Asp Xaa Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Xaa Lys Arg Ala 
            20                  25                  30          


Xaa Pro Ile Glu Val Leu Cys Glu Asn Phe Pro Glu Glu Met Ala Xaa 
        35                  40                  45              


Tyr Leu Arg Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro Asp Tyr 
    50                  55                  60                  


Asp Tyr Leu Arg Lys Leu Phe Xaa Asp Leu Phe Asp Arg Ser Gly Phe 
65                  70                  75                  80  


Val Phe Asp Tyr Asp Arg Pro Pro Ser Ala Pro Ser Xaa Pro Xaa Cys 
                85                  90                  95      


Pro Pro Ser Leu Ser Ser Gly Xaa Lys Pro Ser Arg Xaa Ala Lys Xaa 
            100                 105                 110         


Arg Arg 
        


<210> 7104
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<400> 7104
Met Asp Phe Asp Lys Lys Gly Gly Lys Gly Glu Xaa Glu Glu Gly Arg 
1               5                   10                  15      


Arg Met Ser Lys Ala Gly Gly Gly Arg Ser Ser His Gly Ile Arg Ser 
            20                  25                  30          


Ser Gly Xaa Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val 
        35                  40                  45              


Gly Lys Lys Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys 
    50                  55                  60                  


Asn Leu Tyr Xaa Asn Glu Tyr Val Ala Ile Lys Leu 
65                  70                  75      


<210> 7105
<211> 415
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<400> 7105
Met Asp Phe Asp Lys Lys Gly Gly Lys Gly Glu Xaa Glu Glu Gly Arg 
1               5                   10                  15      


Arg Met Ser Lys Ala Gly Gly Gly Arg Ser Ser His Gly Ile Arg Ser 
            20                  25                  30          


Ser Gly Xaa Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val 
        35                  40                  45              


Gly Lys Lys Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys 
    50                  55                  60                  


Asn Leu Tyr Xaa Asn Glu Tyr Val Ala Ile Lys Leu Glu Pro Ile Lys 
65                  70                  75                  80  


Ser Arg Ala Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln Leu 
                85                  90                  95      


Ser Ala Xaa Glu Gly Val Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly 
            100                 105                 110         


Lys Tyr Asn Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp 
        115                 120                 125             


Leu Phe Asp Leu Cys Asp Arg Xaa Phe Xaa Leu Lys Xaa Val Leu Met 
    130                 135                 140                 


Ile Ala Ile Gln Leu Ile Xaa Arg Met Glu Tyr Val His Xaa Lys Ser 
145                 150                 155                 160 


Leu Ile Tyr Arg Asp Val Lys Pro Glu Asn Phe Leu Val Gly Arg Pro 
                165                 170                 175     


Gly Xaa Lys Arg Gln His Ala Ile His Ile Ile Asp Phe Gly Leu Ala 
            180                 185                 190         


Lys Glu Tyr Ile Asp Pro Glu Xaa Lys Lys His Ile Pro Tyr Arg Glu 
        195                 200                 205             


His Lys Ser Leu Xaa Gly Xaa Ala Arg Tyr Met Ser Ile Asn Xaa His 
    210                 215                 220                 


Leu Gly Lys Glu Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu Gly His 
225                 230                 235                 240 


Met Phe Met Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys 
                245                 250                 255     


Ala Asp Xaa Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Xaa Lys Arg 
            260                 265                 270         


Ala Xaa Pro Ile Glu Val Leu Cys Glu Asn Phe Pro Glu Glu Met Ala 
        275                 280                 285             


Xaa Tyr Leu Arg Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro Asp 
    290                 295                 300                 


Tyr Asp Tyr Leu Arg Lys Leu Phe Xaa Asp Leu Phe Asp Arg Ser Gly 
305                 310                 315                 320 


Phe Val Phe Asp Tyr Glu Tyr Asp Trp Ala Gly Lys Pro Leu Pro Xaa 
                325                 330                 335     


Pro Ile Gly Xaa Val His Xaa Asp Leu Pro Ser Gln Pro Gln Leu Arg 
            340                 345                 350         


Asp Lys Xaa Gln Pro His Ser Lys Asn Gln Ala Leu Asn Ser Xaa Asn 
        355                 360                 365             


Gly Glu Leu Asn Ala Asp Asp Pro Xaa Ala Gly His Ser Asn Ala Pro 
    370                 375                 380                 


Ile Xaa Ala Pro Ala Glu Val Glu Val Ala Asp Glu Xaa Lys Cys Cys 
385                 390                 395                 400 


Cys Phe Phe Lys Arg Arg Lys Arg Lys Ser Leu Gln Arg His Lys 
                405                 410                 415 


<210> 7106
<211> 84
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<400> 7106
Met Asp Phe Asp Lys Lys Gly Gly Lys Gly Glu Xaa Glu Glu Gly Arg 
1               5                   10                  15      


Arg Met Ser Lys Ala Gly Gly Gly Arg Ser Ser His Gly Ile Arg Ser 
            20                  25                  30          


Ser Gly Xaa Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val 
        35                  40                  45              


Gly Lys Lys Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Trp 
    50                  55                  60                  


Phe Gln Arg Cys Trp Gly Lys Ala Glu Gly Lys His Glu Arg Leu Gln 
65                  70                  75                  80  


Gly Gln Gly Ala 
                


<210> 7107
<211> 101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<400> 7107
Xaa Arg Pro Gly Arg Arg Ala Gly Xaa Gln Gly Gly Ser Lys Ala Asp 
1               5                   10                  15      


His Arg Pro Pro Gln Ala Asp Xaa Leu Lys Glu Arg Tyr Gln Lys Ile 
            20                  25                  30          


Gly Asp Xaa Lys Arg Ala Xaa Pro Ile Glu Val Leu Cys Glu Asn Phe 
        35                  40                  45              


Pro Glu Glu Met Ala Xaa Tyr Leu Arg Tyr Val Arg Arg Leu Asp Phe 
    50                  55                  60                  


Phe Glu Lys Pro Asp Tyr Asp Tyr Leu Arg Lys Leu Phe Xaa Asp Leu 
65                  70                  75                  80  


Phe Asp Arg Ser Gly Phe Val Phe Asp Tyr Glu Tyr Asp Trp Ala Gly 
                85                  90                  95      


Lys Pro Leu Pro Xaa 
            100     


<210> 7108
<211> 299
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<400> 7108
Xaa Ser Lys Ala Gly Gly Gly Arg Ser Ser His Gly Ile Arg Ser Ser 
1               5                   10                  15      


Gly Xaa Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val Gly 
            20                  25                  30          


Lys Lys Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys Asn 
        35                  40                  45              


Leu Tyr Xaa Asn Glu Tyr Val Ala Ile Lys Leu Val Ser Arg Pro Leu 
    50                  55                  60                  


His Pro Xaa Pro Ala Asp Val Pro Pro Arg Asp Phe Arg Ala Ala Xaa 
65                  70                  75                  80  


Arg Ser Pro Gly Asp Ser Leu Leu Cys Pro Gln Glu Pro Ile Lys Ser 
                85                  90                  95      


Arg Ala Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln Leu Ser 
            100                 105                 110         


Ala Xaa Glu Gly Val Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly Lys 
        115                 120                 125             


Tyr Asn Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu 
    130                 135                 140                 


Phe Asp Leu Cys Asp Arg Xaa Phe Xaa Leu Lys Xaa Val Leu Met Ile 
145                 150                 155                 160 


Ala Ile Gln Leu Ile Xaa Arg Met Glu Tyr Val His Xaa Lys Ser Leu 
                165                 170                 175     


Ile Tyr Arg Asp Val Lys Pro Glu Asn Phe Leu Val Gly Arg Pro Gly 
            180                 185                 190         


Xaa Lys Arg Gln His Ala Ile His Ile Ile Asp Phe Gly Leu Ala Lys 
        195                 200                 205             


Glu Tyr Ile Asp Pro Glu Xaa Lys Lys His Ile Pro Tyr Arg Glu His 
    210                 215                 220                 


Lys Ser Leu Xaa Gly Xaa Ala Arg Tyr Met Ser Ile Asn Xaa His Leu 
225                 230                 235                 240 


Gly Lys Glu Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu Gly His Met 
                245                 250                 255     


Phe Met Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala 
            260                 265                 270         


Asp Xaa Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Xaa Lys Arg Ala 
        275                 280                 285             


Xaa Pro Ile Glu Val Leu Cys Glu Asn Phe Pro 
    290                 295                 


<210> 7109
<211> 235
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<400> 7109
Xaa Ser Arg Ala Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln 
1               5                   10                  15      


Leu Ser Ala Xaa Gly Xaa Gly Arg Pro Ala Gly Gly Ala Gly Ala Ala 
            20                  25                  30          


Gln Gly Gln Gly Gly Gly Cys Arg Arg Xaa Pro Val Arg Leu Ser Ser 
        35                  40                  45              


Ala Ala Glu Gly Val Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly Lys 
    50                  55                  60                  


Tyr Asn Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu 
65                  70                  75                  80  


Phe Asp Leu Cys Asp Arg Xaa Phe Xaa Leu Lys Xaa Val Leu Met Ile 
                85                  90                  95      


Ala Ile Gln Leu Ile Xaa Arg Met Glu Tyr Val His Xaa Lys Ser Leu 
            100                 105                 110         


Ile Tyr Arg Asp Val Lys Pro Glu Asn Phe Leu Val Gly Arg Pro Gly 
        115                 120                 125             


Xaa Lys Arg Gln His Ala Ile His Ile Ile Asp Phe Gly Leu Ala Lys 
    130                 135                 140                 


Glu Tyr Ile Asp Pro Glu Xaa Lys Lys His Ile Pro Tyr Arg Glu His 
145                 150                 155                 160 


Lys Ser Leu Xaa Gly Xaa Ala Arg Tyr Met Ser Ile Asn Xaa His Leu 
                165                 170                 175     


Gly Lys Glu Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu Gly His Met 
            180                 185                 190         


Phe Met Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala 
        195                 200                 205             


Asp Xaa Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Xaa Lys Arg Ala 
    210                 215                 220                 


Xaa Pro Ile Glu Val Leu Cys Glu Asn Phe Pro 
225                 230                 235 


<210> 7110
<211> 206
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<400> 7110
Xaa Ser Arg Ala Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln 
1               5                   10                  15      


Leu Ser Ala Xaa Gly Xaa Gly Arg Pro Ala Gly Gly Ala Gly Ala Ala 
            20                  25                  30          


Gln Gly Gln Gly Gly Gly Cys Arg Arg Xaa Pro Val Arg Leu Ser Ser 
        35                  40                  45              


Ala Ala Glu Gly Val Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly Lys 
    50                  55                  60                  


Tyr Asn Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu 
65                  70                  75                  80  


Phe Asp Leu Cys Asp Arg Xaa Phe Xaa Leu Lys Xaa Val Leu Met Ile 
                85                  90                  95      


Ala Ile Gln Leu Ile Xaa Arg Met Glu Tyr Val His Xaa Lys Ser Leu 
            100                 105                 110         


Ile Tyr Arg Asp Val Lys Pro Glu Asn Phe Leu Val Gly Arg Pro Gly 
        115                 120                 125             


Xaa Lys Arg Gln His Ala Ile His Ile Ile Asp Phe Gly Leu Ala Lys 
    130                 135                 140                 


Glu Tyr Ile Asp Pro Glu Xaa Lys Lys His Ile Pro Tyr Arg Glu His 
145                 150                 155                 160 


Lys Ser Leu Xaa Gly Xaa Ala Arg Tyr Met Ser Ile Asn Xaa His Leu 
                165                 170                 175     


Gly Lys Gly Arg His Ala Gln Gly Ala Val Pro Glu Asp Arg Gly His 
            180                 185                 190         


Gln Xaa Arg His Ala His Arg Gly Ala Leu Arg Glu Leu Pro 
        195                 200                 205     


<210> 7111
<211> 423
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<400> 7111
Met Glu Asn Lys Lys Lys Asp Lys Asp Lys Ser Asp Asp Arg Met Ala 
1               5                   10                  15      


Arg Pro Ser Gly Arg Ser Gly His Asn Xaa Arg Gly Xaa Gly Ser Ser 
            20                  25                  30          


Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val Gly Lys Lys 
        35                  40                  45              


Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys Asn Leu Tyr 
    50                  55                  60                  


Xaa Asn Glu Tyr Val Ala Ile Lys Leu Glu Pro Met Lys Ser Arg Ala 
65                  70                  75                  80  


Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln Leu Gly Ser Gly 
                85                  90                  95      


Asp Gly Ile Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly Lys Tyr Asn 
            100                 105                 110         


Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asp 
        115                 120                 125             


Leu Cys Asp Arg Xaa Phe Ser Leu Lys Xaa Val Leu Met Ile Ala Ile 
    130                 135                 140                 


Gln Leu Ile Ser Arg Met Glu Tyr Val His Ser Lys Asn Leu Ile Tyr 
145                 150                 155                 160 


Arg Asp Val Lys Pro Glu Asn Phe Leu Ile Gly Arg Pro Gly Asn Lys 
                165                 170                 175     


Xaa Gln Gln Val Ile His Ile Ile Asp Phe Gly Leu Ala Lys Glu Tyr 
            180                 185                 190         


Ile Asp Pro Glu Xaa Lys Lys His Ile Pro Tyr Arg Glu His Lys Ser 
        195                 200                 205             


Leu Xaa Gly Xaa Ala Arg Tyr Met Ser Ile Asn Xaa His Leu Gly Lys 
    210                 215                 220                 


Glu Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu Gly His Met Phe Met 
225                 230                 235                 240 


Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Asp Xaa 
                245                 250                 255     


Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Xaa Lys Arg Ala Xaa Pro 
            260                 265                 270         


Ile Glu Val Leu Cys Glu Asn Phe Pro Glu Met Ala Xaa Tyr Leu Arg 
        275                 280                 285             


Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro Asp Tyr Asp Tyr Leu 
    290                 295                 300                 


Arg Lys Leu Phe Xaa Asp Leu Phe Asp Arg Lys Gly Tyr Met Phe Asp 
305                 310                 315                 320 


Tyr Glu Tyr Asp Trp Ile Gly Lys Gln Leu Pro Xaa Pro Val Gly Ala 
                325                 330                 335     


Val Gln Gln Asp Pro Ala Leu Ser Ser Asn Arg Glu Ala His Gln His 
            340                 345                 350         


Arg Asp Lys Met Gln Gln Ser Lys Asn Gln Val Val Ser Ser Xaa Asn 
        355                 360                 365             


Gly Glu Leu Asn Xaa Asp Asp Pro Xaa Ala Gly Arg Ser Asn Ala Pro 
    370                 375                 380                 


Ile Xaa Ala Pro Xaa Glu Val Glu Val Met Asp Glu Xaa Asn Cys Gln 
385                 390                 395                 400 


Lys Val Leu Asn Met Trp Cys Cys Cys Phe Phe Lys Arg Arg Lys Arg 
                405                 410                 415     


Lys Xaa Ile Gln Arg His Lys 
            420             


<210> 7112
<211> 424
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<400> 7112
Met Glu Asn Lys Lys Lys Asp Lys Asp Lys Ser Asp Asp Arg Met Ala 
1               5                   10                  15      


Arg Pro Ser Gly Arg Ser Gly His Asn Xaa Arg Gly Xaa Gly Ser Ser 
            20                  25                  30          


Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val Gly Lys Lys 
        35                  40                  45              


Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys Asn Leu Tyr 
    50                  55                  60                  


Xaa Asn Glu Tyr Val Ala Ile Lys Leu Glu Pro Met Lys Ser Arg Ala 
65                  70                  75                  80  


Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln Leu Gly Ser Gly 
                85                  90                  95      


Asp Gly Ile Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly Lys Tyr Asn 
            100                 105                 110         


Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asp 
        115                 120                 125             


Leu Cys Asp Arg Xaa Phe Ser Leu Lys Xaa Val Leu Met Ile Ala Ile 
    130                 135                 140                 


Gln Leu Ile Ser Arg Met Glu Tyr Val His Ser Lys Asn Leu Ile Tyr 
145                 150                 155                 160 


Arg Asp Val Lys Pro Glu Asn Phe Leu Ile Gly Arg Pro Gly Asn Lys 
                165                 170                 175     


Xaa Gln Gln Val Ile His Ile Ile Asp Phe Gly Leu Ala Lys Glu Tyr 
            180                 185                 190         


Ile Asp Pro Glu Xaa Lys Lys His Ile Pro Tyr Arg Glu His Lys Ser 
        195                 200                 205             


Leu Xaa Gly Xaa Ala Arg Tyr Met Ser Ile Asn Xaa His Leu Gly Lys 
    210                 215                 220                 


Glu Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu Gly His Met Phe Met 
225                 230                 235                 240 


Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Asp Xaa 
                245                 250                 255     


Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Xaa Lys Arg Ala Xaa Pro 
            260                 265                 270         


Ile Glu Val Leu Cys Glu Asn Phe Pro Glu Glu Met Ala Xaa Tyr Leu 
        275                 280                 285             


Arg Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro Asp Tyr Asp Tyr 
    290                 295                 300                 


Leu Arg Lys Leu Phe Xaa Asp Leu Phe Asp Arg Lys Gly Tyr Met Phe 
305                 310                 315                 320 


Asp Tyr Glu Tyr Asp Trp Ile Gly Lys Gln Leu Pro Xaa Pro Val Gly 
                325                 330                 335     


Ala Val Gln Gln Asp Pro Ala Leu Ser Ser Asn Arg Glu Ala His Gln 
            340                 345                 350         


His Arg Asp Lys Met Gln Gln Ser Lys Asn Gln Val Val Ser Ser Xaa 
        355                 360                 365             


Asn Gly Glu Leu Asn Xaa Asp Asp Pro Xaa Ala Gly Arg Ser Asn Ala 
    370                 375                 380                 


Pro Ile Xaa Ala Pro Xaa Glu Val Glu Val Met Asp Glu Xaa Asn Cys 
385                 390                 395                 400 


Gln Lys Val Leu Asn Met Trp Cys Cys Cys Phe Phe Lys Arg Arg Lys 
                405                 410                 415     


Arg Lys Xaa Ile Gln Arg His Lys 
            420                 


<210> 7113
<211> 447
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<400> 7113
Met Glu Asn Lys Lys Lys Asp Lys Asp Lys Ser Asp Asp Arg Met Ala 
1               5                   10                  15      


Arg Pro Ser Gly Arg Ser Gly His Asn Xaa Arg Gly Xaa Gly Ser Ser 
            20                  25                  30          


Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val Gly Lys Lys 
        35                  40                  45              


Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys Asn Leu Tyr 
    50                  55                  60                  


Xaa Asn Glu Tyr Val Ala Ile Lys Leu Glu Pro Met Lys Ser Arg Ala 
65                  70                  75                  80  


Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln Leu Gly Ser Gly 
                85                  90                  95      


Asp Gly Ile Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly Lys Tyr Asn 
            100                 105                 110         


Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asp 
        115                 120                 125             


Leu Cys Asp Arg Xaa Phe Ser Leu Lys Xaa Val Leu Met Ile Ala Ile 
    130                 135                 140                 


Gln Leu Ile Ser Arg Met Glu Tyr Val His Ser Lys Asn Leu Ile Tyr 
145                 150                 155                 160 


Arg Asp Val Lys Pro Glu Asn Phe Leu Ile Gly Arg Pro Gly Asn Lys 
                165                 170                 175     


Xaa Gln Gln Val Ile His Ile Ile Asp Phe Gly Leu Ala Lys Glu Tyr 
            180                 185                 190         


Ile Asp Pro Glu Xaa Lys Lys His Ile Pro Tyr Arg Glu His Lys Ser 
        195                 200                 205             


Leu Xaa Gly Xaa Ala Arg Tyr Met Ser Ile Asn Xaa His Leu Gly Lys 
    210                 215                 220                 


Glu Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu Gly His Met Phe Met 
225                 230                 235                 240 


Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Asp Xaa 
                245                 250                 255     


Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Xaa Lys Arg Ala Xaa Pro 
            260                 265                 270         


Ile Glu Val Leu Cys Glu Asn Phe Pro Glu Met Ala Xaa Tyr Leu Arg 
        275                 280                 285             


Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro Asp Tyr Asp Tyr Leu 
    290                 295                 300                 


Arg Lys Leu Phe Xaa Asp Leu Phe Asp Arg Lys Gly Tyr Met Phe Asp 
305                 310                 315                 320 


Tyr Glu Tyr Asp Trp Ile Gly Lys Gln Leu Pro Xaa Pro Val Gly Ala 
                325                 330                 335     


Val Gln Gln Asp Pro Ala Leu Ser Ser Asn Arg Glu Ala His Gln His 
            340                 345                 350         


Arg Asp Lys Met Gln Gln Ser Lys Asn Gln Ser Ala Asp His Arg Ala 
        355                 360                 365             


Ala Trp Asp Ser Gln Gln Ala Asn Pro His His Leu Arg Ala His Leu 
    370                 375                 380                 


Ala Ala Asp Arg His Gly Gly Ser Val Gln Val Val Ser Ser Xaa Asn 
385                 390                 395                 400 


Gly Glu Leu Asn Xaa Asp Asp Pro Xaa Ala Gly Arg Ser Asn Ala Pro 
                405                 410                 415     


Ile Xaa Ala Pro Xaa Glu Val Glu Val Met Asp Glu Xaa Lys Cys Cys 
            420                 425                 430         


Cys Phe Phe Lys Arg Arg Lys Arg Lys Xaa Ile Gln Arg His Lys 
        435                 440                 445         


<210> 7114
<211> 455
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<400> 7114
Met Glu Asn Lys Lys Lys Asp Lys Asp Lys Ser Asp Asp Arg Met Ala 
1               5                   10                  15      


Arg Pro Ser Gly Arg Ser Gly His Asn Xaa Arg Gly Xaa Gly Ser Ser 
            20                  25                  30          


Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val Gly Lys Lys 
        35                  40                  45              


Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys Asn Leu Tyr 
    50                  55                  60                  


Xaa Asn Glu Tyr Val Ala Ile Lys Leu Glu Pro Met Lys Ser Arg Ala 
65                  70                  75                  80  


Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln Leu Gly Ser Gly 
                85                  90                  95      


Asp Gly Ile Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly Lys Tyr Asn 
            100                 105                 110         


Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asp 
        115                 120                 125             


Leu Cys Asp Arg Xaa Phe Ser Leu Lys Xaa Val Leu Met Ile Ala Ile 
    130                 135                 140                 


Gln Leu Ile Ser Arg Met Glu Tyr Val His Ser Lys Asn Leu Ile Tyr 
145                 150                 155                 160 


Arg Asp Val Lys Pro Glu Asn Phe Leu Ile Gly Arg Pro Gly Asn Lys 
                165                 170                 175     


Xaa Gln Gln Val Ile His Ile Ile Asp Phe Gly Leu Ala Lys Glu Tyr 
            180                 185                 190         


Ile Asp Pro Glu Xaa Lys Lys His Ile Pro Tyr Arg Glu His Lys Ser 
        195                 200                 205             


Leu Xaa Gly Xaa Ala Arg Tyr Met Ser Ile Asn Xaa His Leu Gly Lys 
    210                 215                 220                 


Glu Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu Gly His Met Phe Met 
225                 230                 235                 240 


Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Asp Xaa 
                245                 250                 255     


Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Xaa Lys Arg Ala Xaa Pro 
            260                 265                 270         


Ile Glu Val Leu Cys Glu Asn Phe Pro Glu Met Ala Xaa Tyr Leu Arg 
        275                 280                 285             


Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro Asp Tyr Asp Tyr Leu 
    290                 295                 300                 


Arg Lys Leu Phe Xaa Asp Leu Phe Asp Arg Lys Gly Tyr Met Phe Asp 
305                 310                 315                 320 


Tyr Glu Tyr Asp Trp Ile Gly Lys Gln Leu Pro Xaa Pro Val Gly Ala 
                325                 330                 335     


Val Gln Gln Asp Pro Ala Leu Ser Ser Asn Arg Glu Ala His Gln His 
            340                 345                 350         


Arg Asp Lys Met Gln Gln Ser Lys Asn Gln Ser Ala Asp His Arg Ala 
        355                 360                 365             


Ala Trp Asp Ser Gln Gln Ala Asn Pro His His Leu Arg Ala His Leu 
    370                 375                 380                 


Ala Ala Asp Arg His Gly Gly Ser Val Gln Val Val Ser Ser Xaa Asn 
385                 390                 395                 400 


Gly Glu Leu Asn Xaa Asp Asp Pro Xaa Ala Gly Arg Ser Asn Ala Pro 
                405                 410                 415     


Ile Xaa Ala Pro Xaa Glu Val Glu Val Met Asp Glu Xaa Asn Cys Gln 
            420                 425                 430         


Lys Val Leu Asn Met Trp Cys Cys Cys Phe Phe Lys Arg Arg Lys Arg 
        435                 440                 445             


Lys Xaa Ile Gln Arg His Lys 
    450                 455 


<210> 7115
<211> 348
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<400> 7115
Met Lys Ser Arg Ala Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys 
1               5                   10                  15      


Gln Leu Gly Ser Gly Asp Gly Ile Pro Gln Val Tyr Tyr Phe Gly Pro 
            20                  25                  30          


Cys Gly Lys Tyr Asn Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu 
        35                  40                  45              


Glu Asp Leu Phe Asp Leu Cys Asp Arg Xaa Phe Ser Leu Lys Xaa Val 
    50                  55                  60                  


Leu Met Ile Ala Ile Gln Leu Ile Ser Arg Met Glu Tyr Val His Ser 
65                  70                  75                  80  


Lys Asn Leu Ile Tyr Arg Asp Val Lys Pro Glu Asn Phe Leu Ile Gly 
                85                  90                  95      


Arg Pro Gly Asn Lys Xaa Gln Gln Val Ile His Ile Ile Asp Phe Gly 
            100                 105                 110         


Leu Ala Lys Glu Tyr Ile Asp Pro Glu Xaa Lys Lys His Ile Pro Tyr 
        115                 120                 125             


Arg Glu His Lys Ser Leu Xaa Gly Xaa Ala Arg Tyr Met Ser Ile Asn 
    130                 135                 140                 


Xaa His Leu Gly Lys Glu Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu 
145                 150                 155                 160 


Gly His Met Phe Met Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly 
                165                 170                 175     


Leu Lys Ala Asp Xaa Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Xaa 
            180                 185                 190         


Lys Arg Ala Xaa Pro Ile Glu Val Leu Cys Glu Asn Phe Pro Glu Met 
        195                 200                 205             


Ala Xaa Tyr Leu Arg Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro 
    210                 215                 220                 


Asp Tyr Asp Tyr Leu Arg Lys Leu Phe Xaa Asp Leu Phe Asp Arg Lys 
225                 230                 235                 240 


Gly Tyr Met Phe Asp Tyr Glu Tyr Asp Trp Ile Gly Lys Gln Leu Pro 
                245                 250                 255     


Xaa Pro Val Gly Ala Val Gln Gln Asp Pro Ala Leu Ser Ser Asn Arg 
            260                 265                 270         


Glu Ala His Gln His Arg Asp Lys Met Gln Gln Ser Lys Asn Gln Val 
        275                 280                 285             


Val Ser Ser Xaa Asn Gly Glu Leu Asn Xaa Asp Asp Pro Xaa Ala Gly 
    290                 295                 300                 


Arg Ser Asn Ala Pro Ile Xaa Ala Pro Xaa Glu Val Glu Val Met Asp 
305                 310                 315                 320 


Glu Xaa Asn Cys Gln Lys Val Leu Asn Met Trp Cys Cys Cys Phe Phe 
                325                 330                 335     


Lys Arg Arg Lys Arg Lys Xaa Ile Gln Arg His Lys 
            340                 345             


<210> 7116
<211> 311
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<400> 7116
Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asp Leu 
1               5                   10                  15      


Cys Asp Arg Xaa Phe Ser Leu Lys Xaa Val Leu Met Ile Ala Ile Gln 
            20                  25                  30          


Leu Ile Ser Arg Met Glu Tyr Val His Ser Lys Asn Leu Ile Tyr Arg 
        35                  40                  45              


Asp Val Lys Pro Glu Asn Phe Leu Ile Gly Arg Pro Gly Asn Lys Xaa 
    50                  55                  60                  


Gln Gln Val Ile His Ile Ile Asp Phe Gly Leu Ala Lys Glu Tyr Ile 
65                  70                  75                  80  


Asp Pro Glu Xaa Lys Lys His Ile Pro Tyr Arg Glu His Lys Ser Leu 
                85                  90                  95      


Xaa Gly Xaa Ala Arg Tyr Met Ser Ile Asn Xaa His Leu Gly Lys Glu 
            100                 105                 110         


Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu Gly His Met Phe Met Tyr 
        115                 120                 125             


Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Asp Xaa Leu 
    130                 135                 140                 


Lys Glu Arg Tyr Gln Lys Ile Gly Asp Xaa Lys Arg Ala Xaa Pro Ile 
145                 150                 155                 160 


Glu Val Leu Cys Glu Asn Phe Pro Glu Glu Met Ala Xaa Tyr Leu Arg 
                165                 170                 175     


Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro Asp Tyr Asp Tyr Leu 
            180                 185                 190         


Arg Lys Leu Phe Xaa Asp Leu Phe Asp Arg Lys Gly Tyr Met Phe Asp 
        195                 200                 205             


Tyr Glu Tyr Asp Trp Ile Gly Lys Gln Leu Pro Xaa Pro Val Gly Ala 
    210                 215                 220                 


Val Gln Gln Asp Pro Ala Leu Ser Ser Asn Arg Glu Ala His Gln His 
225                 230                 235                 240 


Arg Asp Lys Met Gln Gln Ser Lys Asn Gln Val Val Ser Ser Xaa Asn 
                245                 250                 255     


Gly Glu Leu Asn Xaa Asp Asp Pro Xaa Ala Gly Arg Ser Asn Ala Pro 
            260                 265                 270         


Ile Xaa Ala Pro Xaa Glu Val Glu Val Met Asp Glu Xaa Asn Cys Gln 
        275                 280                 285             


Lys Val Leu Asn Met Trp Cys Cys Cys Phe Phe Lys Arg Arg Lys Arg 
    290                 295                 300                 


Lys Xaa Ile Gln Arg His Lys 
305                 310     


<210> 7117
<211> 164
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<400> 7117
Xaa Ala Asp Xaa Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Xaa Lys 
1               5                   10                  15      


Arg Ala Xaa Pro Ile Glu Val Leu Cys Glu Asn Phe Pro Glu Glu Met 
            20                  25                  30          


Ala Xaa Tyr Leu Arg Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro 
        35                  40                  45              


Asp Tyr Asp Tyr Leu Arg Lys Leu Phe Xaa Asp Leu Phe Asp Arg Lys 
    50                  55                  60                  


Gly Tyr Met Phe Asp Tyr Glu Tyr Asp Trp Ile Gly Lys Gln Leu Pro 
65                  70                  75                  80  


Xaa Pro Val Gly Ala Val Gln Gln Asp Pro Ala Leu Ser Ser Asn Arg 
                85                  90                  95      


Glu Ala His Gln His Arg Asp Lys Met Gln Gln Ser Lys Asn Gln Val 
            100                 105                 110         


Val Ser Ser Xaa Asn Gly Glu Leu Asn Xaa Asp Asp Pro Xaa Ala Gly 
        115                 120                 125             


Arg Ser Asn Ala Pro Ile Xaa Ala Pro Xaa Glu Val Glu Val Met Asp 
    130                 135                 140                 


Glu Xaa Lys Cys Cys Cys Phe Phe Lys Arg Arg Lys Arg Lys Xaa Ile 
145                 150                 155                 160 


Gln Arg His Lys 
                


<210> 7118
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 7118
Asp Tyr Ile Asp Lys Tyr Asn Ile Glu Leu Asp Pro Arg Phe Asn Asp 
1               5                   10                  15      


Ile Leu Gly Arg His Ser Arg Lys Arg Trp Glu Arg Phe Val His Ser 
            20                  25                  30          


Glu Asn Gln His Leu Val Ser Pro Glu Ala Leu Asp Phe Leu Asp Lys 
        35                  40                  45              


Leu Leu Arg Tyr Asp His Gln Ser Arg Leu Xaa Ala Arg Glu Ala Met 
    50                  55                  60                  


Glu His Pro Tyr Phe Tyr Xaa Val Val Lys Asp Gln Ala Arg Met Gly 
65                  70                  75                  80  


Ser Ser Ser Met Pro Gly Gly Ser Xaa Pro Val Ser Ser Ala Asn Met 
                85                  90                  95      


Met Ser Glu Pro Gln Phe Glu Gly Gln Arg Asp Ile His His Ala Ala 
            100                 105                 110         


Val Arg Leu Gly Gln Leu 
        115             


<210> 7119
<211> 74
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<400> 7119
Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Xaa Asp Val Asn 
1               5                   10                  15      


Xaa His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Xaa Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys 
65                  70                  


<210> 7120
<211> 80
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<400> 7120
Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Xaa Asp Val Asn 
1               5                   10                  15      


Xaa His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Xaa Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


<210> 7121
<211> 385
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<400> 7121
Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Xaa Asp Val Asn 
1               5                   10                  15      


Xaa His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Xaa Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro Asn Ile Ile Xaa 
                85                  90                  95      


Leu Ala Asp Ile Val Lys Asp Pro Val Ser Arg Xaa Pro Ala Leu Val 
            100                 105                 110         


Phe Glu His Val Asn Asn Xaa Asp Phe Lys Gln Leu Tyr Gln Xaa Leu 
        115                 120                 125             


Xaa Asp Tyr Asp Ile Arg Phe Tyr Met Tyr Glu Ile Leu Lys Ala Leu 
    130                 135                 140                 


Asp Tyr Cys His Ser Met Gly Ile Met His Arg Asp Val Lys Pro His 
145                 150                 155                 160 


Asn Val Met Ile Asp His Glu His Arg Lys Leu Arg Leu Ile Asp Trp 
                165                 170                 175     


Gly Leu Ala Glu Phe Tyr His Pro Gly Gln Glu Tyr Asn Val Arg Val 
            180                 185                 190         


Ala Ser Arg Tyr Phe Lys Gly Pro Glu Leu Leu Val Asp Tyr Gln Met 
        195                 200                 205             


Tyr Asp Tyr Ser Leu Asp Met Trp Ser Leu Gly Cys Met Leu Ala Ser 
    210                 215                 220                 


Met Ile Phe Arg Lys Glu Pro Phe Phe His Gly His Asp Asn Tyr Asp 
225                 230                 235                 240 


Gln Leu Val Arg Ile Ala Lys Val Leu Gly Xaa Glu Asp Leu Tyr Asp 
                245                 250                 255     


Tyr Ile Asp Lys Tyr Asn Ile Glu Leu Asp Pro Arg Phe Asn Asp Ile 
            260                 265                 270         


Leu Gly Arg His Ser Arg Lys Arg Trp Glu Arg Phe Val His Ser Glu 
        275                 280                 285             


Asn Gln His Leu Val Ser Pro Glu Ala Leu Asp Phe Leu Asp Lys Leu 
    290                 295                 300                 


Leu Arg Tyr Asp His Gln Ser Arg Leu Xaa Ala Arg Glu Ala Met Glu 
305                 310                 315                 320 


His Pro Tyr Phe Tyr Xaa Val Val Lys Asp Gln Ala Arg Met Gly Ser 
                325                 330                 335     


Ser Ser Met Pro Gly Gly Ser Xaa Pro Val Ser Ser Ala Asn Met Met 
            340                 345                 350         


Ser Glu Met Lys Phe Cys Arg Val Ala Gln Ala Gly Leu Glu Leu Leu 
        355                 360                 365             


Ser Ser Xaa Val Tyr Pro Pro Trp Pro Pro Lys Val Leu Arg Leu Glu 
    370                 375                 380                 


Ala 
385 


<210> 7122
<211> 391
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<400> 7122
Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Xaa Asp Val Asn 
1               5                   10                  15      


Xaa His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Xaa Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro Asn Ile Ile Xaa 
                85                  90                  95      


Leu Ala Asp Ile Val Lys Asp Pro Val Ser Arg Xaa Pro Ala Leu Val 
            100                 105                 110         


Phe Glu His Val Asn Asn Xaa Asp Phe Lys Gln Leu Tyr Gln Xaa Leu 
        115                 120                 125             


Xaa Asp Tyr Asp Ile Arg Phe Tyr Met Tyr Glu Ile Leu Lys Ala Leu 
    130                 135                 140                 


Asp Tyr Cys His Ser Met Gly Ile Met His Arg Asp Val Lys Pro His 
145                 150                 155                 160 


Asn Val Met Ile Asp His Glu His Arg Lys Leu Arg Leu Ile Asp Trp 
                165                 170                 175     


Gly Leu Ala Glu Phe Tyr His Pro Gly Gln Glu Tyr Asn Val Arg Val 
            180                 185                 190         


Ala Ser Arg Tyr Phe Lys Gly Pro Glu Leu Leu Val Asp Tyr Gln Met 
        195                 200                 205             


Tyr Asp Tyr Ser Leu Asp Met Trp Ser Leu Gly Cys Met Leu Ala Ser 
    210                 215                 220                 


Met Ile Phe Arg Lys Glu Pro Phe Phe His Gly His Asp Asn Tyr Asp 
225                 230                 235                 240 


Gln Leu Val Arg Ile Ala Lys Val Leu Gly Xaa Glu Asp Leu Tyr Asp 
                245                 250                 255     


Tyr Ile Asp Lys Tyr Asn Ile Glu Leu Asp Pro Arg Phe Asn Asp Ile 
            260                 265                 270         


Leu Gly Arg His Ser Arg Lys Arg Trp Glu Arg Phe Val His Ser Glu 
        275                 280                 285             


Asn Gln His Leu Val Ser Pro Glu Ala Leu Asp Phe Leu Asp Lys Leu 
    290                 295                 300                 


Leu Arg Tyr Asp His Gln Ser Arg Leu Xaa Ala Arg Glu Ala Met Glu 
305                 310                 315                 320 


His Pro Tyr Phe Tyr Xaa Val Val Lys Asp Gln Ala Arg Met Gly Ser 
                325                 330                 335     


Ser Ser Met Pro Gly Gly Ser Xaa Pro Val Ser Ser Ala Asn Met Met 
            340                 345                 350         


Ser Gly Ile Ser Ser Val Pro Xaa Pro Ser Pro Leu Gly Pro Leu Ala 
        355                 360                 365             


Gly Ser Pro Val Ile Ala Ala Ala Asn Pro Leu Gly Met Pro Val Pro 
    370                 375                 380                 


Ala Ala Ala Gly Ala Gln Gln 
385                 390     


<210> 7123
<211> 27
<212> PRT
<213> Homo sapiens

<400> 7123
Met Tyr Glu Ile Leu Lys Ala Leu Asp Tyr Cys His Ser Met Gly Ile 
1               5                   10                  15      


Met His Arg Asp Val Lys Pro His Asn Val Met 
            20                  25          


<210> 7124
<211> 255
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<400> 7124
Met Tyr Glu Ile Leu Lys Ala Leu Asp Tyr Cys His Ser Met Gly Ile 
1               5                   10                  15      


Met His Arg Asp Val Lys Pro His Asn Val Met Ile Asp His Glu His 
            20                  25                  30          


Arg Lys Leu Arg Leu Ile Asp Trp Gly Leu Ala Glu Phe Tyr His Pro 
        35                  40                  45              


Gly Gln Glu Tyr Asn Val Arg Val Ala Ser Arg Tyr Phe Lys Gly Pro 
    50                  55                  60                  


Glu Leu Leu Val Asp Tyr Gln Met Tyr Asp Tyr Ser Leu Asp Met Trp 
65                  70                  75                  80  


Ser Leu Gly Cys Met Leu Ala Ser Met Ile Phe Arg Lys Glu Pro Phe 
                85                  90                  95      


Phe His Gly His Asp Asn Tyr Asp Gln Leu Val Arg Ile Ala Lys Val 
            100                 105                 110         


Leu Gly Xaa Glu Asp Leu Tyr Asp Tyr Ile Asp Lys Tyr Asn Ile Glu 
        115                 120                 125             


Leu Asp Pro Arg Phe Asn Asp Ile Leu Gly Arg His Ser Arg Lys Arg 
    130                 135                 140                 


Trp Glu Arg Phe Val His Ser Glu Asn Gln His Leu Val Ser Pro Glu 
145                 150                 155                 160 


Ala Leu Asp Phe Leu Asp Lys Leu Leu Arg Tyr Asp His Gln Ser Arg 
                165                 170                 175     


Leu Xaa Ala Arg Glu Ala Met Glu His Pro Tyr Phe Tyr Xaa Val Val 
            180                 185                 190         


Lys Asp Gln Ala Arg Met Gly Ser Ser Ser Met Pro Gly Gly Ser Xaa 
        195                 200                 205             


Pro Val Ser Ser Ala Asn Met Met Ser Gly Ile Ser Ser Val Pro Xaa 
    210                 215                 220                 


Pro Ser Pro Leu Gly Pro Leu Ala Gly Ser Pro Val Ile Ala Ala Ala 
225                 230                 235                 240 


Asn Pro Leu Gly Met Pro Val Pro Ala Ala Ala Gly Ala Gln Gln 
                245                 250                 255 


<210> 7125
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<400> 7125
Met Pro Gly Pro Ala Ala Gly Ser Arg Ala Arg Val Tyr Ala Glu Val 
1               5                   10                  15      


Asn Ser Leu Arg Ser Arg Glu Tyr Trp Asp Tyr Glu Ala His Val Pro 
            20                  25                  30          


Ser Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg 
        35                  40                  45              


Gly Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Xaa Asn Asn Glu 
    50                  55                  60                  


Arg Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys 
65                  70                  75                  80  


Arg Glu Val Lys Ile Leu Glu Asn Leu Arg Gly Gly Xaa Asn Ile Ile 
                85                  90                  95      


Lys Leu Ile Asp Xaa Val Lys Asp Pro Val Ser Lys Xaa Pro Ala Leu 
            100                 105                 110         


Val Phe Glu Tyr Ile Asn Asn Xaa Asp Phe Lys Gln Leu Tyr Gln Ile 
        115                 120                 125             


Leu Xaa Asp Phe Asp Ile Arg 
    130                 135 


<210> 7126
<211> 350
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<400> 7126
Met Pro Gly Pro Ala Ala Gly Ser Arg Ala Arg Val Tyr Ala Glu Val 
1               5                   10                  15      


Asn Ser Leu Arg Ser Arg Glu Tyr Trp Asp Tyr Glu Ala His Val Pro 
            20                  25                  30          


Ser Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg 
        35                  40                  45              


Gly Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Xaa Asn Asn Glu 
    50                  55                  60                  


Arg Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys 
65                  70                  75                  80  


Arg Glu Val Lys Ile Leu Glu Asn Leu Arg Gly Gly Xaa Asn Ile Ile 
                85                  90                  95      


Lys Leu Ile Asp Xaa Val Lys Asp Pro Val Ser Lys Xaa Pro Ala Leu 
            100                 105                 110         


Val Phe Glu Tyr Ile Asn Asn Xaa Asp Phe Lys Gln Leu Tyr Gln Ile 
        115                 120                 125             


Leu Xaa Asp Phe Asp Ile Arg Phe Tyr Met Tyr Glu Leu Leu Lys Ala 
    130                 135                 140                 


Leu Asp Tyr Cys His Ser Lys Gly Ile Met His Arg Asp Val Lys Pro 
145                 150                 155                 160 


His Asn Val Met Ile Asp His Gln Gln Lys Lys Leu Arg Leu Ile Asp 
                165                 170                 175     


Trp Gly Leu Ala Glu Phe Tyr His Pro Ala Gln Glu Tyr Asn Val Arg 
            180                 185                 190         


Val Ala Ser Arg Tyr Phe Lys Gly Pro Glu Leu Leu Val Asp Tyr Gln 
        195                 200                 205             


Met Tyr Asp Tyr Ser Leu Asp Met Trp Ser Leu Gly Cys Met Leu Ala 
    210                 215                 220                 


Ser Met Ile Phe Arg Arg Glu Pro Phe Phe His Gly Gln Asp Asn Tyr 
225                 230                 235                 240 


Asp Gln Leu Val Arg Ile Ala Lys Val Leu Gly Xaa Glu Glu Leu Tyr 
                245                 250                 255     


Gly Tyr Leu Lys Lys Tyr His Ile Asp Leu Asp Pro His Phe Asn Asp 
            260                 265                 270         


Ile Leu Gly Gln His Ser Arg Lys Arg Trp Glu Asn Phe Ile His Ser 
        275                 280                 285             


Glu Asn Arg His Leu Val Ser Pro Glu Ala Leu Asp Leu Leu Asp Lys 
    290                 295                 300                 


Leu Leu Arg Tyr Asp His Gln Gln Arg Leu Xaa Ala Lys Glu Ala Met 
305                 310                 315                 320 


Glu His Pro Tyr Phe Tyr Pro Val Val Lys Glu Gln Ser Gln Pro Cys 
                325                 330                 335     


Ala Asp Asn Ala Val Leu Ser Ser Gly Leu Xaa Ala Ala Arg 
            340                 345                 350 


<210> 7127
<211> 230
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<400> 7127
Pro Val Lys Lys Lys Lys Ile Lys Arg Glu Val Lys Ile Leu Glu Asn 
1               5                   10                  15      


Leu Arg Gly Gly Xaa Asn Ile Ile Lys Leu Ile Asp Xaa Val Lys Asp 
            20                  25                  30          


Pro Val Ser Lys Xaa Pro Ala Leu Val Phe Glu Tyr Ile Asn Asn Xaa 
        35                  40                  45              


Asp Phe Lys Leu Arg Leu Ile Asp Trp Gly Leu Ala Glu Phe Tyr His 
    50                  55                  60                  


Pro Ala Gln Glu Tyr Asn Val Arg Val Ala Ser Arg Tyr Phe Lys Gly 
65                  70                  75                  80  


Pro Glu Leu Leu Val Asp Tyr Gln Met Tyr Asp Tyr Ser Leu Asp Met 
                85                  90                  95      


Trp Ser Leu Gly Cys Met Leu Ala Ser Met Ile Phe Arg Arg Glu Pro 
            100                 105                 110         


Phe Phe His Gly Gln Asp Asn Tyr Asp Gln Leu Val Arg Ile Ala Lys 
        115                 120                 125             


Val Leu Gly Xaa Glu Glu Leu Tyr Gly Tyr Leu Lys Lys Tyr His Ile 
    130                 135                 140                 


Asp Leu Asp Pro His Phe Asn Asp Ile Leu Gly Gln His Ser Arg Lys 
145                 150                 155                 160 


Arg Trp Glu Asn Phe Ile His Ser Glu Asn Arg His Leu Val Ser Pro 
                165                 170                 175     


Glu Ala Leu Asp Leu Leu Asp Lys Leu Leu Arg Tyr Asp His Gln Gln 
            180                 185                 190         


Arg Leu Xaa Ala Lys Glu Ala Met Glu His Pro Tyr Phe Tyr Pro Val 
        195                 200                 205             


Val Lys Glu Gln Ser Gln Pro Cys Ala Asp Asn Ala Val Leu Ser Ser 
    210                 215                 220                 


Gly Leu Xaa Ala Ala Arg 
225                 230 


<210> 7128
<211> 152
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<400> 7128
Xaa Gly Pro Glu Leu Leu Val Asp Tyr Gln Met Tyr Asp Tyr Ser Leu 
1               5                   10                  15      


Asp Met Trp Ser Leu Gly Cys Met Leu Ala Ser Met Ile Phe Arg Arg 
            20                  25                  30          


Glu Pro Phe Phe His Gly Gln Asp Asn Tyr Asp Gln Leu Val Arg Ile 
        35                  40                  45              


Ala Lys Val Leu Gly Xaa Glu Glu Leu Tyr Gly Tyr Leu Lys Lys Tyr 
    50                  55                  60                  


His Ile Asp Leu Asp Pro His Phe Asn Asp Ile Leu Gly Gln His Ser 
65                  70                  75                  80  


Arg Lys Arg Trp Glu Asn Phe Ile His Ser Glu Asn Arg His Leu Val 
                85                  90                  95      


Ser Pro Glu Ala Leu Asp Leu Leu Asp Lys Leu Leu Arg Tyr Asp His 
            100                 105                 110         


Gln Gln Arg Leu Xaa Ala Lys Glu Ala Met Glu His Pro Tyr Phe Tyr 
        115                 120                 125             


Pro Val Val Lys Glu Gln Ser Gln Pro Cys Ala Asp Asn Ala Val Leu 
    130                 135                 140                 


Ser Ser Gly Leu Xaa Ala Ala Arg 
145                 150         


<210> 7129
<211> 234
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<400> 7129
Met Glu Lys Cys Lys Gly Xaa Ser Arg Met Ala Gly Xaa Xaa Ser Ala 
1               5                   10                  15      


Asp Val Lys Met Ser Ser Ser Glu Glu Val Ser Trp Ile Ser Trp Phe 
            20                  25                  30          


Cys Gly Leu Arg Gly Asn Glu Phe Phe Cys Glu Val Asp Glu Asp Tyr 
        35                  40                  45              


Ile Gln Asp Lys Phe Asn Leu Xaa Gly Leu Asn Glu Gln Val Pro His 
    50                  55                  60                  


Tyr Arg Gln Ala Leu Asp Met Ile Leu Asp Leu Glu Pro Asp Glu Glu 
65                  70                  75                  80  


Leu Glu Asp Asn Pro Asn Gln Ser Asp Leu Ile Glu Gln Ala Ala Glu 
                85                  90                  95      


Met Leu Tyr Gly Leu Ile His Ala Arg Tyr Ile Leu Xaa Asn Arg Gly 
            100                 105                 110         


Ile Ala Gln Met Leu Glu Lys Tyr Gln Gln Gly Asp Phe Gly Tyr Cys 
        115                 120                 125             


Pro Arg Val Tyr Cys Glu Asn Gln Pro Met Leu Pro Ile Gly Leu Ser 
    130                 135                 140                 


Asp Ile Pro Gly Glu Ala Met Val Lys Leu Tyr Cys Pro Lys Cys Met 
145                 150                 155                 160 


Asp Val Tyr Xaa Pro Lys Ser Ser Arg His His His Xaa Asp Gly Ala 
                165                 170                 175     


Tyr Phe Gly Xaa Gly Phe Pro His Met Leu Phe Met Val His Pro Glu 
            180                 185                 190         


Tyr Arg Pro Lys Arg Pro Ala Asn Gln Phe Val Pro Arg Leu Tyr Gly 
        195                 200                 205             


Phe Lys Ile His Pro Met Ala Tyr Gln Leu Gln Leu Gln Ala Ala Ser 
    210                 215                 220                 


Asn Phe Lys Ser Pro Val Lys Xaa Ile Arg 
225                 230                 


<210> 7130
<211> 161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<400> 7130
Met Ser Ser Ser Glu Glu Val Ser Trp Ile Ser Trp Phe Cys Gly Leu 
1               5                   10                  15      


Arg Gly Asn Glu Phe Phe Cys Glu Val Asp Glu Asp Tyr Ile Gln Asp 
            20                  25                  30          


Lys Phe Asn Leu Xaa Gly Leu Asn Glu Gln Val Pro His Tyr Arg Gln 
        35                  40                  45              


Ala Leu Asp Met Ile Leu Asp Leu Glu Pro Asp Glu Glu Leu Glu Asp 
    50                  55                  60                  


Asn Pro Asn Gln Ser Asp Leu Ile Glu Gln Ala Ala Glu Met Leu Tyr 
65                  70                  75                  80  


Gly Leu Ile His Ala Leu Pro Leu Ser Asp Ser Gln Ile Gln Trp Phe 
                85                  90                  95      


Tyr Gln Ala Leu Asn Leu Ser Leu Pro Leu Pro Asn Phe His Ala Gly 
            100                 105                 110         


Xaa Glu Pro Asp Gly Leu Asp Pro Met Val Xaa Leu Ser Leu Asn Leu 
        115                 120                 125             


Gly Leu Ser Phe Ala Glu Leu Cys Arg Met Tyr Leu Phe Leu Asn Ser 
    130                 135                 140                 


Ser Gly Leu Leu Val Leu Pro Gln Ala Gly Leu Leu Xaa Pro His Pro 
145                 150                 155                 160 


Ser 
    


<210> 7131
<211> 161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<400> 7131
Met Ser Ser Ser Glu Glu Val Ser Trp Ile Ser Trp Phe Cys Gly Leu 
1               5                   10                  15      


Arg Gly Asn Glu Phe Phe Cys Glu Val Asp Glu Asp Tyr Ile Gln Asp 
            20                  25                  30          


Lys Phe Asn Leu Xaa Gly Leu Asn Glu Gln Val Pro His Tyr Arg Gln 
        35                  40                  45              


Ala Leu Asp Met Ile Leu Asp Leu Glu Pro Asp Glu Glu Leu Glu Asp 
    50                  55                  60                  


Asn Pro Asn Gln Ser Asp Leu Ile Glu Gln Ala Ala Glu Met Leu Tyr 
65                  70                  75                  80  


Gly Leu Ile His Ala Leu Pro Leu Ser Asp Ser Gln Ile Gln Trp Phe 
                85                  90                  95      


Tyr Gln Ala Leu Asn Leu Ser Leu Pro Leu Pro Asn Phe His Ala Gly 
            100                 105                 110         


Xaa Glu Pro Asp Gly Leu Asp Pro Met Val Xaa Leu Ser Leu Asn Leu 
        115                 120                 125             


Gly Leu Ser Phe Ala Glu Leu Arg Arg Met Tyr Leu Phe Leu Asn Ser 
    130                 135                 140                 


Ser Gly Leu Leu Val Leu Pro Gln Ala Gly Leu Leu Xaa Pro His Pro 
145                 150                 155                 160 


Ser 
    


<210> 7132
<211> 215
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<400> 7132
Met Ser Ser Ser Glu Glu Val Ser Trp Ile Ser Trp Phe Cys Gly Leu 
1               5                   10                  15      


Arg Gly Asn Glu Phe Phe Cys Glu Val Asp Glu Asp Tyr Ile Gln Asp 
            20                  25                  30          


Lys Phe Asn Leu Xaa Gly Leu Asn Glu Gln Val Pro His Tyr Arg Gln 
        35                  40                  45              


Ala Leu Asp Met Ile Leu Asp Leu Glu Pro Asp Glu Glu Leu Glu Asp 
    50                  55                  60                  


Asn Pro Asn Gln Ser Asp Leu Ile Glu Gln Ala Ala Glu Met Leu Tyr 
65                  70                  75                  80  


Gly Leu Ile His Ala Arg Tyr Ile Leu Xaa Asn Arg Gly Ile Ala Gln 
                85                  90                  95      


Met Leu Glu Lys Tyr Gln Gln Gly Asp Phe Gly Tyr Cys Pro Arg Val 
            100                 105                 110         


Tyr Cys Glu Asn Gln Pro Met Leu Pro Ile Gly Leu Ser Asp Ile Pro 
        115                 120                 125             


Gly Glu Ala Met Val Lys Leu Tyr Cys Pro Lys Cys Met Asp Val Tyr 
    130                 135                 140                 


Xaa Pro Lys Ser Ser Arg His His His Xaa Asp Gly Ala Tyr Phe Gly 
145                 150                 155                 160 


Xaa Gly Phe Pro His Met Leu Phe Met Val His Pro Glu Tyr Arg Pro 
                165                 170                 175     


Lys Arg Pro Ala Asn Gln Phe Val Pro Arg Leu Tyr Gly Phe Lys Ile 
            180                 185                 190         


His Pro Met Ala Tyr Gln Leu Gln Leu Gln Ala Ala Ser Asn Phe Lys 
        195                 200                 205             


Ser Pro Val Lys Xaa Ile Arg 
    210                 215 


<210> 7133
<211> 228
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<400> 7133
Met Ser Ser Ser Glu Glu Val Ser Trp Ile Ser Trp Phe Cys Gly Leu 
1               5                   10                  15      


Arg Gly Asn Glu Phe Phe Cys Glu Val Asp Glu Asp Tyr Ile Gln Asp 
            20                  25                  30          


Lys Phe Asn Leu Xaa Gly Leu Asn Glu Gln Val Pro His Tyr Arg Gln 
        35                  40                  45              


Ala Leu Asp Met Ile Leu Asp Leu Glu Pro Asp Glu Glu Leu Glu Asp 
    50                  55                  60                  


Asn Pro Asn Gln Ser Asp Leu Ile Glu Gln Ala Ala Glu Met Leu Tyr 
65                  70                  75                  80  


Gly Leu Ile His Ala Arg Tyr Ile Leu Xaa Asn Arg Gly Ile Ala Gln 
                85                  90                  95      


Met Leu Glu Lys Tyr Gln Gln Gly Asp Phe Gly Tyr Cys Pro Arg Val 
            100                 105                 110         


Tyr Cys Glu Asn Gln Pro Met Leu Pro Ile Gly Leu Ser Asp Ile Pro 
        115                 120                 125             


Gly Glu Ala Met Val Lys Leu Tyr Cys Pro Lys Cys Met Asp Val Tyr 
    130                 135                 140                 


Xaa Pro Lys Ser Ser Arg His His His Xaa Asp Gly Ala Tyr Phe Gly 
145                 150                 155                 160 


Xaa Gly Phe Pro His Met Leu Phe Met Val His Pro Glu Tyr Arg Pro 
                165                 170                 175     


Lys Arg Pro Ala Asn Gln Phe Val Pro Ser Ser Cys Ser Arg His Pro 
            180                 185                 190         


Asp Val Pro Leu Leu Pro Arg Arg Arg Pro Phe Cys Arg Met His Phe 
        195                 200                 205             


Arg Leu Arg Glu Val Tyr His Gln Gln Leu Ile Pro Val His Gly Asp 
    210                 215                 220                 


His His Leu Leu 
225             


<210> 7134
<211> 304
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<400> 7134
Met Ser Ser Ser Glu Glu Val Ser Trp Ile Ser Trp Phe Cys Gly Leu 
1               5                   10                  15      


Arg Gly Asn Glu Phe Phe Cys Glu Val Asp Glu Asp Tyr Ile Gln Asp 
            20                  25                  30          


Lys Phe Asn Leu Xaa Gly Leu Asn Glu Gln Val Pro His Tyr Arg Gln 
        35                  40                  45              


Ala Leu Asp Met Ile Leu Asp Leu Glu Pro Asp Glu Glu Leu Glu Asp 
    50                  55                  60                  


Asn Pro Asn Gln Ser Asp Leu Ile Glu Gln Ala Ala Glu Met Leu Tyr 
65                  70                  75                  80  


Gly Leu Ile His Ala Arg Tyr Ile Leu Xaa Asn Arg Gly Ile Ala Gln 
                85                  90                  95      


Met Leu Glu Lys Tyr Gln Gln Gly Asp Phe Gly Tyr Cys Pro Arg Val 
            100                 105                 110         


Tyr Cys Glu Asn Gln Pro Met Leu Pro Ile Val Pro Val Pro Asp Ile 
        115                 120                 125             


Arg Xaa Cys His Phe Cys Leu Val Glu Asp Pro Ser Val Gly Cys Ile 
    130                 135                 140                 


Ser Gly Ser Glu Lys Cys Xaa Ile Ser Ser Ser Ser Leu Cys Met Val 
145                 150                 155                 160 


Ile Xaa Ile Tyr Tyr Asp Val Lys Val Arg Phe Ile Val Arg Gly Cys 
                165                 170                 175     


Gly Gln Tyr Ile Ser Tyr Arg Cys Gln Glu Lys Arg Asn Xaa Tyr Phe 
            180                 185                 190         


Ala Glu Tyr Trp Tyr Gln Ala Gln Cys Cys Gln Tyr Asp Tyr Cys Asn 
        195                 200                 205             


Ser Trp Ser Ser Pro Gln Leu Gln Ser Ser Leu Pro Glu Pro His Asp 
    210                 215                 220                 


Arg Pro Leu Ala Leu Pro Leu Ser Asp Ser Gln Ile Gln Trp Phe Tyr 
225                 230                 235                 240 


Gln Ala Leu Asn Leu Ser Leu Pro Leu Pro Asn Phe His Ala Gly Xaa 
                245                 250                 255     


Glu Pro Asp Gly Leu Asp Pro Met Val Xaa Leu Ser Leu Asn Leu Gly 
            260                 265                 270         


Leu Ser Phe Ala Glu Leu Arg Arg Met Tyr Leu Phe Leu Asn Ser Ser 
        275                 280                 285             


Gly Leu Leu Val Leu Pro Gln Ala Gly Leu Leu Xaa Pro His Pro Ser 
    290                 295                 300                 


<210> 7135
<211> 304
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<400> 7135
Met Ser Ser Ser Glu Glu Val Ser Trp Ile Ser Trp Phe Cys Gly Leu 
1               5                   10                  15      


Arg Gly Asn Glu Phe Phe Cys Glu Val Asp Glu Asp Tyr Ile Gln Asp 
            20                  25                  30          


Lys Phe Asn Leu Xaa Gly Leu Asn Glu Gln Val Pro His Tyr Arg Gln 
        35                  40                  45              


Ala Leu Asp Met Ile Leu Asp Leu Glu Pro Asp Glu Glu Leu Glu Asp 
    50                  55                  60                  


Asn Pro Asn Gln Ser Asp Leu Ile Glu Gln Ala Ala Glu Met Leu Tyr 
65                  70                  75                  80  


Gly Leu Ile His Ala Arg Tyr Ile Leu Xaa Asn Arg Gly Ile Ala Gln 
                85                  90                  95      


Met Leu Glu Lys Tyr Gln Gln Gly Asp Phe Gly Tyr Cys Pro Arg Val 
            100                 105                 110         


Tyr Cys Glu Asn Gln Pro Met Leu Pro Ile Val Pro Val Pro Asp Ile 
        115                 120                 125             


Arg Xaa Cys His Phe Cys Leu Val Glu Asp Pro Ser Val Gly Cys Ile 
    130                 135                 140                 


Ser Gly Ser Glu Lys Cys Xaa Ile Ser Ser Ser Ser Leu Cys Met Val 
145                 150                 155                 160 


Ile Xaa Ile Tyr Tyr Asp Val Lys Val Arg Phe Ile Val Arg Gly Cys 
                165                 170                 175     


Gly Gln Tyr Ile Ser Tyr Arg Cys Gln Glu Lys Arg Asn Xaa Tyr Phe 
            180                 185                 190         


Ala Glu Tyr Trp Tyr Gln Ala Gln Cys Cys Gln Tyr Asp Tyr Cys Asn 
        195                 200                 205             


Ser Trp Ser Ser Pro Gln Leu Gln Ser Ser Leu Pro Glu Pro His Asp 
    210                 215                 220                 


Arg Pro Leu Ala Leu Pro Leu Ser Asp Ser Gln Ile Gln Trp Phe Tyr 
225                 230                 235                 240 


Gln Ala Leu Asn Leu Ser Leu Pro Leu Pro Asn Phe His Ala Gly Xaa 
                245                 250                 255     


Glu Pro Asp Gly Leu Asp Pro Met Val Xaa Leu Ser Leu Asn Leu Gly 
            260                 265                 270         


Leu Ser Phe Ala Glu Leu Cys Arg Met Tyr Leu Phe Leu Asn Ser Ser 
        275                 280                 285             


Gly Leu Leu Val Leu Pro Gln Ala Gly Leu Leu Xaa Pro His Pro Ser 
    290                 295                 300                 


<210> 7136
<211> 2322
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (783)..(783)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(804)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (903)..(903)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(955)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1022)..(1022)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1039)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1059)..(1059)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1075)..(1075)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1169)..(1169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1210)..(1210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1222)..(1222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1315)..(1315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1374)..(1374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1416)..(1416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1439)..(1439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1463)..(1463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1465)..(1465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1477)..(1478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1480)..(1480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1489)..(1489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1500)..(1500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1512)..(1512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1529)..(1529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1535)..(1535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1551)..(1551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1566)..(1566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1575)..(1575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1589)..(1589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1591)..(1591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1604)..(1604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1613)..(1613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1639)..(1639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1647)..(1647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1673)..(1673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1689)..(1689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1724)..(1724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1752)..(1752)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1793)..(1793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1817)..(1817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1824)..(1824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1844)..(1844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1892)..(1892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1895)..(1895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1997)..(1997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2015)..(2015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2042)..(2042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2060)..(2060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2066)..(2066)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2077)..(2077)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2102)..(2102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2114)..(2114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2143)..(2143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2162)..(2162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2184)..(2184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2193)..(2193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2195)..(2195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2252)..(2252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2261)..(2261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2272)..(2272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2274)..(2274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2287)..(2287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (2310)..(2310)
<223> Selenocysteine

<400> 7136
Met Gln Ser Gly Pro Arg Pro Pro Leu Pro Ala Pro Gly Leu Ala Leu 
1               5                   10                  15      


Ala Leu Xaa Leu Xaa Met Leu Ala Arg Leu Ala Ser Ala Ala Ser Phe 
            20                  25                  30          


Phe Gly Glu Asn His Leu Glu Val Pro Val Ala Xaa Ala Leu Xaa Asp 
        35                  40                  45              


Ile Asp Leu Gln Leu Gln Phe Ser Xaa Ser Gln Pro Glu Ala Leu Leu 
    50                  55                  60                  


Leu Leu Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln Leu Tyr Ser 
65                  70                  75                  80  


Gly Arg Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu Leu Arg Leu 
                85                  90                  95      


Gln Xaa Pro Ala Glu Xaa Leu Leu Ser Asp Ser Ile Pro His Xaa Val 
            100                 105                 110         


Val Leu Xaa Val Val Glu Gly Trp Ala Xaa Leu Ser Val Asp Gly Phe 
        115                 120                 125             


Leu Asn Ala Ser Ser Ala Val Pro Gly Ala Pro Leu Glu Val Pro Tyr 
    130                 135                 140                 


Gly Leu Phe Val Gly Gly Xaa Gly Xaa Leu Gly Leu Pro Tyr Leu Arg 
145                 150                 155                 160 


Gly Xaa Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala Xaa Leu Asn 
                165                 170                 175     


Gly Arg Ser Leu Leu Arg Pro Leu Xaa Pro Asp Val His Glu Gly Cys 
            180                 185                 190         


Ala Glu Glu Phe Ser Ala Ser Asp Asp Val Ala Leu Gly Phe Ser Gly 
        195                 200                 205             


Pro His Ser Leu Ala Ala Phe Pro Ala Trp Gly Xaa Gln Asp Glu Gly 
    210                 215                 220                 


Xaa Leu Glu Phe Xaa Leu Xaa Xaa Gln Ser Arg Gln Ala Pro Leu Ala 
225                 230                 235                 240 


Phe Gln Ala Gly Gly Arg Arg Gly Asp Phe Ile Tyr Val Asp Ile Phe 
                245                 250                 255     


Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Xaa Val Leu 
            260                 265                 270         


Leu His Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val Ser 
        275                 280                 285             


Val His Ile Asn Ala His Arg Leu Glu Ile Ser Val Asp Gln Tyr Pro 
    290                 295                 300                 


Xaa His Xaa Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg Gly 
305                 310                 315                 320 


Ser Leu Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg His Leu Gln 
                325                 330                 335     


Glu His Arg Leu Gly Leu Xaa Pro Glu Ala Xaa Asn Ala Ser Leu Leu 
            340                 345                 350         


Gly Cys Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg Gly Leu Arg 
        355                 360                 365             


Glu Ala Leu Leu Xaa Arg Asn Met Ala Ala Gly Cys Arg Leu Glu Glu 
    370                 375                 380                 


Glu Glu Tyr Glu Asp Asp Ala Tyr Gly His Tyr Glu Ala Phe Ser Xaa 
385                 390                 395                 400 


Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys Val 
                405                 410                 415     


Pro Glu Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Xaa Gln Leu Leu 
            420                 425                 430         


Xaa Ile Ser Pro Leu Val Val Ala Glu Gly Gly Xaa Ala Trp Leu Glu 
        435                 440                 445             


Trp Arg His Val Gln Pro Xaa Leu Asp Leu Met Glu Ala Glu Leu Arg 
    450                 455                 460                 


Lys Ser Gln Val Leu Phe Ser Val Xaa Arg Gly Ala Arg His Gly Glu 
465                 470                 475                 480 


Leu Glu Leu Asp Ile Pro Gly Ala Gln Ala Arg Lys Met Phe Xaa Leu 
                485                 490                 495     


Leu Asp Val Val Asn Arg Lys Ala Arg Phe Ile His Asp Gly Ser Glu 
            500                 505                 510         


Asp Xaa Ser Asp Gln Leu Val Leu Glu Val Ser Val Xaa Ala Arg Val 
        515                 520                 525             


Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Xaa Tyr Leu Leu Pro Ile 
    530                 535                 540                 


Gln Val Asn Pro Val Asn Asp Pro Pro His Ile Ile Phe Pro His Gly 
545                 550                 555                 560 


Ser Leu Met Val Ile Leu Glu His Xaa Gln Lys Pro Leu Gly Pro Glu 
                565                 570                 575     


Val Phe Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Xaa Phe 
            580                 585                 590         


Gln Val Leu Gly Xaa Ser Ser Gly Leu Pro Val Glu Arg Arg Asp Gln 
        595                 600                 605             


Pro Gly Glu Pro Ala Xaa Glu Phe Ser Cys Arg Glu Leu Glu Ala Gly 
    610                 615                 620                 


Ser Leu Val Tyr Val His Arg Gly Gly Pro Ala Gln Asp Leu Xaa Phe 
625                 630                 635                 640 


Arg Val Ser Asp Gly Leu Gln Ala Ser Pro Pro Ala Xaa Leu Lys Val 
                645                 650                 655     


Val Ala Ile Arg Pro Ala Ile Gln Ile His Arg Ser Xaa Gly Leu Arg 
            660                 665                 670         


Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro Ala Asn Leu Ser Val 
        675                 680                 685             


Glu Xaa Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Xaa 
    690                 695                 700                 


Gly Ala Leu Gln Phe Gly Glu Leu Gln Lys Gln Gly Ala Gly Gly Val 
705                 710                 715                 720 


Glu Gly Ala Glu Trp Trp Ala Xaa Gln Ala Phe His Gln Arg Asp Val 
                725                 730                 735     


Glu Gln Gly Arg Val Arg Tyr Leu Ser Xaa Asp Pro Gln His His Ala 
            740                 745                 750         


Tyr Asp Xaa Val Glu Asn Leu Ala Leu Glu Val Gln Val Gly Gln Glu 
        755                 760                 765             


Ile Leu Ser Asn Leu Ser Phe Pro Val Xaa Ile Gln Arg Ala Xaa Val 
    770                 775                 780                 


Trp Met Leu Arg Leu Glu Pro Leu His Xaa Gln Asn Xaa Gln Gln Glu 
785                 790                 795                 800 


Xaa Leu Xaa Xaa Ala His Leu Glu Ala Xaa Leu Glu Glu Ala Gly Pro 
                805                 810                 815     


Ser Pro Pro Xaa Phe His Tyr Glu Val Val Gln Ala Pro Arg Lys Gly 
            820                 825                 830         


Asn Leu Gln Leu Gln Gly Xaa Arg Leu Ser Asp Gly Gln Gly Phe Xaa 
        835                 840                 845             


Gln Asp Asp Ile Gln Ala Gly Arg Val Xaa Tyr Gly Ala Xaa Ala Arg 
    850                 855                 860                 


Ala Ser Glu Ala Val Glu Asp Xaa Phe Arg Phe Arg Val Xaa Ala Pro 
865                 870                 875                 880 


Pro Tyr Phe Ser Pro Leu Tyr Xaa Phe Pro Ile His Ile Gly Gly Asp 
                885                 890                 895     


Pro Asp Ala Pro Val Leu Xaa Asn Val Leu Leu Val Val Pro Glu Gly 
            900                 905                 910         


Gly Glu Gly Val Leu Ser Ala Asp His Leu Phe Val Lys Ser Leu Asn 
        915                 920                 925             


Ser Ala Ser Tyr Leu Tyr Glu Val Met Glu Arg Pro Arg His Gly Arg 
    930                 935                 940                 


Leu Ala Trp Arg Gly Xaa Gln Asp Lys Xaa Xaa Met Val Xaa Ser Phe 
945                 950                 955                 960 


Xaa Asn Glu Asp Leu Leu Arg Gly Arg Leu Val Tyr Gln His Asp Asp 
                965                 970                 975     


Ser Glu Xaa Xaa Glu Asp Asp Ile Pro Phe Val Ala Xaa Arg Gln Gly 
            980                 985                 990         


Glu Ser Ser Gly Asp Met Ala Trp  Glu Glu Val Arg Gly  Val Phe Arg 
        995                 1000                 1005             


Val Ala  Ile Gln Pro Val Asn  Asp His Ala Pro Val  Gln Xaa Ile 
    1010                 1015                 1020             


Ser Arg  Ile Phe His Val Ala  Arg Gly Gly Arg Arg  Leu Leu Xaa 
    1025                 1030                 1035             


Xaa Asp  Asp Val Ala Phe Ser  Asp Ala Asp Ser Gly  Phe Ala Asp 
    1040                 1045                 1050             


Ala Gln  Leu Val Leu Xaa Arg  Lys Asp Leu Leu Phe  Gly Ser Ile 
    1055                 1060                 1065             


Val Ala  Val Asp Glu Pro Xaa  Arg Pro Ile Tyr Arg  Phe Xaa Gln 
    1070                 1075                 1080             


Glu Asp  Leu Arg Lys Arg Arg  Val Leu Phe Val His  Ser Gly Ala 
    1085                 1090                 1095             


Asp Arg  Gly Trp Ile Gln Leu  Gln Val Ser Asp Gly  Gln His Gln 
    1100                 1105                 1110             


Ala Xaa  Ala Leu Leu Glu Val  Gln Ala Ser Glu Pro  Tyr Leu Arg 
    1115                 1120                 1125             


Val Ala  Asn Gly Ser Ser Leu  Val Val Pro Gln Gly  Gly Gln Gly 
    1130                 1135                 1140             


Xaa Ile  Asp Xaa Ala Val Leu  His Leu Asp Xaa Asn  Leu Asp Ile 
    1145                 1150                 1155             


Arg Ser  Gly Asp Glu Val His  Tyr His Val Xaa Ala  Gly Pro Arg 
    1160                 1165                 1170             


Trp Gly  Gln Leu Val Arg Ala  Gly Gln Pro Ala Xaa  Ala Phe Ser 
    1175                 1180                 1185             


Gln Gln  Asp Leu Leu Asp Gly  Ala Val Leu Tyr Ser  His Asn Gly 
    1190                 1195                 1200             


Ser Leu  Ser Pro Arg Asp Xaa  Met Ala Phe Ser Val  Glu Ala Gly 
    1205                 1210                 1215             


Pro Val  His Xaa Asp Ala Xaa  Leu Gln Val Xaa Ile  Ala Leu Glu 
    1220                 1225                 1230             


Gly Pro  Leu Ala Pro Leu Lys  Leu Val Arg His Lys  Lys Ile Tyr 
    1235                 1240                 1245             


Val Phe  Gln Gly Glu Ala Ala  Glu Ile Arg Arg Asp  Gln Leu Glu 
    1250                 1255                 1260             


Ala Ala  Gln Glu Ala Val Pro  Pro Ala Asp Ile Val  Phe Ser Val 
    1265                 1270                 1275             


Lys Ser  Pro Pro Ser Ala Gly  Tyr Leu Val Met Val  Ser Arg Gly 
    1280                 1285                 1290             


Ala Leu  Ala Asp Glu Pro Pro  Ser Leu Asp Pro Val  Gln Ser Phe 
    1295                 1300                 1305             


Ser Gln  Glu Ala Val Asp Xaa  Gly Arg Val Leu Tyr  Leu His Ser 
    1310                 1315                 1320             


Arg Pro  Glu Ala Trp Ser Asp  Ala Phe Ser Leu Asp  Val Ala Ser 
    1325                 1330                 1335             


Gly Leu  Gly Ala Pro Leu Glu  Gly Val Leu Val Glu  Leu Glu Val 
    1340                 1345                 1350             


Leu Pro  Ala Ala Ile Pro Leu  Glu Ala Gln Asn Phe  Ser Val Pro 
    1355                 1360                 1365             


Glu Gly  Gly Ser Leu Xaa Leu  Ala Pro Pro Leu Leu  Arg Val Ser 
    1370                 1375                 1380             


Gly Pro  Tyr Phe Pro Xaa Leu  Leu Gly Leu Ser Leu  Gln Val Leu 
    1385                 1390                 1395             


Glu Pro  Pro Gln His Gly Ala  Leu Gln Lys Glu Asp  Gly Pro Gln 
    1400                 1405                 1410             


Ala Arg  Xaa Leu Ser Ala Phe  Ser Trp Arg Met Val  Glu Glu Gln 
    1415                 1420                 1425             


Leu Ile  Arg Tyr Val His Asp  Gly Ser Glu Xaa Leu  Xaa Asp Ser 
    1430                 1435                 1440             


Phe Val  Leu Met Ala Asn Ala  Ser Glu Met Asp Arg  Gln Ser His 
    1445                 1450                 1455             


Pro Val  Ala Phe Xaa Val Xaa  Val Leu Pro Val Asn  Asp Gln Pro 
    1460                 1465                 1470             


Pro Ile  Leu Xaa Xaa Asn Xaa  Gly Leu Gln Met Trp  Glu Gly Ala 
    1475                 1480                 1485             


Xaa Ala  Pro Ile Pro Ala Glu  Ala Leu Arg Ser Xaa  Asp Gly Asp 
    1490                 1495                 1500             


Ser Gly  Ser Glu Asp Leu Val  Tyr Xaa Ile Glu Gln  Pro Ser Asn 
    1505                 1510                 1515             


Gly Arg  Val Val Leu Arg Gly  Ala Pro Gly Xaa Glu  Val Arg Ser 
    1520                 1525                 1530             


Phe Xaa  Gln Ala Gln Leu Asp  Gly Gly Leu Val Leu  Phe Ser His 
    1535                 1540                 1545             


Arg Gly  Xaa Leu Asp Gly Gly  Phe Arg Phe Arg Leu  Ser Asp Gly 
    1550                 1555                 1560             


Glu His  Xaa Ser Pro Gly His  Phe Phe Arg Val Xaa  Ala Gln Lys 
    1565                 1570                 1575             


Gln Val  Leu Leu Ser Leu Lys  Gly Ser Gln Xaa Leu  Xaa Val Cys 
    1580                 1585                 1590             


Pro Gly  Ser Val Gln Pro Leu  Ser Ser Gln Xaa Leu  Arg Ala Ser 
    1595                 1600                 1605             


Ser Ser  Ala Gly Xaa Asp Pro  Gln Leu Leu Leu Tyr  Arg Val Val 
    1610                 1615                 1620             


Arg Gly  Pro Gln Leu Gly Arg  Leu Phe His Ala Gln  Gln Asp Ser 
    1625                 1630                 1635             


Xaa Gly  Glu Ala Leu Val Asn  Phe Xaa Gln Ala Glu  Val Tyr Ala 
    1640                 1645                 1650             


Gly Asn  Ile Leu Tyr Glu His  Glu Met Pro Pro Glu  Pro Phe Trp 
    1655                 1660                 1665             


Glu Ala  His Asp Xaa Leu Glu  Leu Gln Leu Ser Ser  Pro Pro Ala 
    1670                 1675                 1680             


Arg Asp  Val Ala Ala Xaa Leu  Ala Val Ala Val Ser  Phe Glu Ala 
    1685                 1690                 1695             


Ala Cys  Pro Gln Arg Pro Ser  His Leu Trp Lys Asn  Lys Gly Leu 
    1700                 1705                 1710             


Trp Val  Pro Glu Gly Gln Arg  Ala Arg Ile Xaa Val  Ala Ala Leu 
    1715                 1720                 1725             


Asp Ala  Ser Asn Leu Leu Ala  Ser Val Pro Ser Pro  Gln Arg Ser 
    1730                 1735                 1740             


Glu His  Asp Val Leu Phe Gln  Val Xaa Gln Phe Pro  Ser Arg Gly 
    1745                 1750                 1755             


Gln Leu  Leu Val Ser Glu Glu  Pro Leu His Ala Gly  Gln Pro His 
    1760                 1765                 1770             


Phe Leu  Gln Ser Gln Leu Ala  Ala Gly Gln Leu Val  Tyr Ala His 
    1775                 1780                 1785             


Gly Gly  Gly Gly Xaa Gln Gln  Asp Gly Phe His Phe  Arg Ala His 
    1790                 1795                 1800             


Leu Gln  Gly Pro Ala Gly Ala  Ser Val Ala Gly Pro  Gln Xaa Ser 
    1805                 1810                 1815             


Glu Ala  Phe Ala Ile Xaa Val  Arg Asp Val Asn Glu  Arg Pro Pro 
    1820                 1825                 1830             


Gln Pro  Gln Ala Ser Val Pro  Leu Arg Leu Xaa Arg  Gly Ser Arg 
    1835                 1840                 1845             


Ala Pro  Ile Ser Arg Ala Gln  Leu Ser Val Val Asp  Pro Asp Ser 
    1850                 1855                 1860             


Ala Pro  Gly Glu Ile Glu Tyr  Glu Val Gln Arg Ala  Pro His Asn 
    1865                 1870                 1875             


Gly Phe  Leu Ser Leu Val Gly  Gly Gly Leu Gly Pro  Val Xaa Arg 
    1880                 1885                 1890             


Phe Xaa  Gln Ala Asp Val Asp  Ser Gly Arg Leu Ala  Phe Val Ala 
    1895                 1900                 1905             


Asn Gly  Ser Ser Val Ala Gly  Ile Phe Gln Leu Ser  Met Ser Asp 
    1910                 1915                 1920             


Gly Ala  Ser Pro Pro Leu Pro  Met Ser Leu Ala Val  Asp Ile Leu 
    1925                 1930                 1935             


Pro Ser  Ala Ile Glu Val Gln  Leu Arg Ala Pro Leu  Glu Val Pro 
    1940                 1945                 1950             


Gln Ala  Leu Gly Arg Ser Ser  Leu Ser Gln Gln Gln  Leu Arg Val 
    1955                 1960                 1965             


Val Ser  Asp Arg Glu Glu Pro  Glu Ala Ala Tyr Arg  Leu Ile Gln 
    1970                 1975                 1980             


Gly Pro  Gln Tyr Gly His Leu  Leu Val Gly Gly Arg  Pro Xaa Ser 
    1985                 1990                 1995             


Ala Phe  Ser Gln Phe Gln Ile  Asp Gln Gly Glu Val  Val Phe Ala 
    2000                 2005                 2010             


Phe Xaa  Asn Phe Ser Ser Ser  His Asp His Phe Arg  Val Leu Ala 
    2015                 2020                 2025             


Leu Ala  Arg Gly Val Asn Ala  Ser Ala Val Val Asn  Val Xaa Val 
    2030                 2035                 2040             


Arg Ala  Leu Leu His Val Trp  Ala Gly Gly Pro Trp  Pro Gln Gly 
    2045                 2050                 2055             


Ala Xaa  Leu Arg Leu Asp Pro  Xaa Val Leu Asp Ala  Gly Glu Leu 
    2060                 2065                 2070             


Ala Asn  Arg Xaa Gly Ser Val  Pro Arg Phe Arg Leu  Leu Glu Gly 
    2075                 2080                 2085             


Pro Arg  His Gly Arg Val Val  Arg Val Pro Arg Ala  Arg Xaa Glu 
    2090                 2095                 2100             


Pro Gly  Gly Ser Gln Leu Val  Glu Gln Phe Xaa Gln  Gln Asp Leu 
    2105                 2110                 2115             


Glu Asp  Gly Arg Leu Gly Leu  Glu Val Gly Arg Pro  Glu Gly Arg 
    2120                 2125                 2130             


Ala Pro  Gly Pro Ala Gly Asp  Ser Leu Xaa Leu Glu  Leu Trp Ala 
    2135                 2140                 2145             


Gln Gly  Val Pro Pro Ala Val  Ala Ser Leu Asp Phe  Ala Xaa Glu 
    2150                 2155                 2160             


Pro Tyr  Asn Ala Ala Arg Pro  Tyr Ser Val Ala Leu  Leu Ser Val 
    2165                 2170                 2175             


Pro Glu  Ala Ala Arg Xaa Glu  Ala Gly Lys Pro Glu  Ser Ser Xaa 
    2180                 2185                 2190             


Pro Xaa  Gly Glu Pro Gly Pro  Met Ala Ser Ser Pro  Glu Pro Ala 
    2195                 2200                 2205             


Val Ala  Lys Gly Gly Phe Leu  Ser Phe Leu Glu Ala  Asn Met Phe 
    2210                 2215                 2220             


Ser Val  Ile Ile Pro Met Cys  Leu Val Leu Leu Leu  Leu Ala Leu 
    2225                 2230                 2235             


Ile Leu  Pro Leu Leu Phe Tyr  Leu Arg Lys Arg Asn  Lys Xaa Gly 
    2240                 2245                 2250             


Lys His  Asp Val Gln Val Leu  Xaa Ala Lys Pro Arg  Asn Gly Leu 
    2255                 2260                 2265             


Ala Gly  Asp Xaa Glu Xaa Phe  Arg Lys Val Glu Pro  Gly Gln Ala 
    2270                 2275                 2280             


Ile Pro  Leu Xaa Ala Val Pro  Gly Gln Gly Pro Pro  Pro Gly Gly 
    2285                 2290                 2295             


Gln Pro  Asp Pro Glu Leu Leu  Gln Phe Cys Arg Xaa  Pro Asn Pro 
    2300                 2305                 2310             


Ala Leu  Lys Asn Gly Gln Tyr  Trp Val 
    2315                 2320         


<210> 7137
<211> 589
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (441)..(441)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<400> 7137
Met Xaa Gly Leu Leu Lys Arg Lys Phe Asp Gln Leu Asp Glu Asp Asn 
1               5                   10                  15      


Ser Ser Val Ser Ser Ser Ser Ser Ser Ser Gly Cys Gln Ser Arg Ser 
            20                  25                  30          


Cys Ser Pro Ser Ser Ser Val Ser Arg Ala Trp Asp Ser Glu Glu Glu 
        35                  40                  45              


Gly Pro Trp Asp Gln Met Pro Leu Pro Asp Arg Asp Phe Cys Gly Pro 
    50                  55                  60                  


Arg Ser Phe Xaa Pro Leu Ser Ile Leu Lys Arg Ala Arg Arg Glu Arg 
65                  70                  75                  80  


Pro Gly Arg Val Ala Phe Asp Gly Ile Xaa Val Phe Tyr Phe Pro Arg 
                85                  90                  95      


Cys Gln Gly Phe Xaa Ser Val Pro Ser Arg Gly Gly Cys Xaa Leu Gly 
            100                 105                 110         


Met Ala Leu Arg His Ser Ala Cys Arg Arg Phe Ser Leu Ala Glu Phe 
        115                 120                 125             


Ala Gln Glu Gln Ala Arg Ala Arg His Glu Lys Leu Arg Gln Arg Leu 
    130                 135                 140                 


Lys Glu Glu Lys Leu Glu Met Leu Gln Trp Lys Leu Ser Ala Ala Gly 
145                 150                 155                 160 


Val Pro Gln Ala Glu Ala Gly Leu Pro Pro Val Val Asp Ala Ile Asp 
                165                 170                 175     


Asp Ala Ser Val Glu Glu Asp Leu Ala Val Ala Val Ala Gly Gly Arg 
            180                 185                 190         


Leu Glu Glu Val Ser Phe Leu Gln Pro Tyr Pro Ala Arg Arg Arg Arg 
        195                 200                 205             


Ala Leu Leu Arg Ala Ser Gly Val Arg Arg Ile Asp Arg Glu Glu Lys 
    210                 215                 220                 


Arg Glu Leu Gln Ala Leu Arg Gln Ser Arg Glu Asp Cys Gly Cys His 
225                 230                 235                 240 


Cys Asp Arg Ile Cys Asp Pro Glu Xaa Cys Ser Cys Ser Leu Ala Gly 
                245                 250                 255     


Ile Lys Cys Gln Met Asp His Xaa Ala Phe Pro Cys Gly Cys Cys Arg 
            260                 265                 270         


Glu Gly Cys Glu Asn Pro Met Gly Arg Val Glu Phe Asn Gln Ala Arg 
        275                 280                 285             


Val Gln Xaa His Phe Ile His Xaa Leu Xaa Arg Leu Gln Leu Glu Gln 
    290                 295                 300                 


Glu Ala Glu Ser Phe Arg Glu Leu Glu Ala Pro Ala Gln Gly Ser Pro 
305                 310                 315                 320 


Pro Ser Pro Gly Glu Glu Ala Leu Val Pro Xaa Phe Pro Leu Ala Lys 
                325                 330                 335     


Pro Pro Met Asn Asn Glu Leu Gly Asp Asn Ser Cys Ser Ser Asp Met 
            340                 345                 350         


Xaa Asp Ser Ser Xaa Ala Ser Ser Ser Ala Ser Gly Xaa Ser Glu Ala 
        355                 360                 365             


Pro Asp Cys Pro Xaa His Pro Gly Leu Pro Gly Pro Gly Phe Gln Pro 
    370                 375                 380                 


Gly Val Asp Asp Asp Ser Leu Ala Arg Ile Leu Ser Phe Ser Asp Ser 
385                 390                 395                 400 


Asp Phe Gly Gly Glu Glu Glu Glu Glu Glu Glu Gly Ser Val Gly Asn 
                405                 410                 415     


Leu Asp Asn Leu Ser Cys Phe His Pro Ala Asp Ile Phe Gly Xaa Ser 
            420                 425                 430         


Asp Pro Gly Gly Leu Ala Ser Trp Xaa His Ser Tyr Ser Gly Cys Ser 
        435                 440                 445             


Phe Xaa Ser Gly Val Leu Asp Glu Asn Ala Asn Leu Asp Ala Ser Cys 
    450                 455                 460                 


Phe Leu Asn Gly Gly Leu Glu Gly Ser Arg Glu Gly Ser Leu Pro Gly 
465                 470                 475                 480 


Xaa Ser Val Pro Pro Ser Met Asp Ala Gly Arg Ser Ser Ser Val Asp 
                485                 490                 495     


Leu Ser Leu Ser Ser Cys Asp Ser Phe Glu Leu Leu Gln Ala Leu Pro 
            500                 505                 510         


Asp Tyr Ser Leu Gly Pro His Tyr Xaa Ser Gln Lys Val Ser Asp Ser 
        515                 520                 525             


Leu Asp Asn Ile Glu Ala Pro His Phe Pro Leu Pro Gly Leu Ser Pro 
    530                 535                 540                 


Pro Gly Asp Ala Ser Ser Cys Phe Leu Glu Ser Leu Met Gly Phe Ser 
545                 550                 555                 560 


Glu Pro Ala Ala Glu Ala Leu Asp Pro Phe Ile Asp Ser Gln Phe Glu 
                565                 570                 575     


Asp Xaa Val Pro Ala Ser Leu Met Glu Pro Val Pro Val 
            580                 585                 


<210> 7138
<211> 66
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<400> 7138
Met Ala Gln Arg His Asn Ser Val Arg Ser Tyr Xaa Leu Cys Glu Phe 
1               5                   10                  15      


Ala Gln Glu Gln Glu Val Asn His Arg Glu Ile Leu Arg Glu His Leu 
            20                  25                  30          


Lys Glu Glu Lys Leu His Ala Lys Lys Met Lys Leu Xaa Lys Asn Gly 
        35                  40                  45              


Xaa Val Glu Ser Val Glu Ala Asp Gly Leu Xaa Leu Asp Asp Val Ser 
    50                  55                  60                  


Asp Glu 
65      


<210> 7139
<211> 58
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 7139
Met Asp Ala Phe Xaa Gly Ser Gly Leu Lys Arg Lys Phe Asp Asp Val 
1               5                   10                  15      


Asp Val Gly Ser Ser Val Ser Asn Ser Asp Asp Glu Ile Ser Ser Ser 
            20                  25                  30          


Asp Ser Ala Asp Ser Cys Asp Ser Leu Asn Pro Pro Xaa Xaa Ala Ser 
        35                  40                  45              


Phe Xaa Pro Xaa Ser Ile Leu Lys Arg Gln 
    50                  55              


<210> 7140
<211> 86
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<400> 7140
Met Asp Ala Phe Xaa Gly Ser Gly Leu Lys Arg Lys Phe Asp Asp Val 
1               5                   10                  15      


Asp Val Gly Ser Ser Val Ser Asn Ser Asp Asp Glu Ile Ser Ser Ser 
            20                  25                  30          


Asp Ser Ala Asp Ser Cys Asp Ser Leu Asn Pro Pro Xaa Xaa Ala Ser 
        35                  40                  45              


Phe Xaa Pro Xaa Ser Ile Leu Lys Arg Gln Lys Gln Leu Arg Arg Lys 
    50                  55                  60                  


Asn Val Arg Phe Asp Gln Val Xaa Val Tyr Tyr Phe Ala Arg Arg Gln 
65                  70                  75                  80  


Gly Phe Xaa Ser Val Pro 
                85      


<210> 7141
<211> 114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<400> 7141
Met Asp Ala Phe Xaa Gly Ser Gly Leu Lys Arg Lys Phe Asp Asp Val 
1               5                   10                  15      


Asp Val Gly Ser Ser Val Ser Asn Ser Asp Asp Glu Ile Ser Ser Ser 
            20                  25                  30          


Asp Ser Ala Asp Ser Cys Asp Ser Leu Asn Pro Pro Xaa Xaa Ala Ser 
        35                  40                  45              


Phe Xaa Pro Xaa Ser Ile Leu Lys Arg Gln Lys Gln Leu Arg Arg Lys 
    50                  55                  60                  


Asn Val Arg Phe Asp Gln Val Xaa Val Tyr Tyr Phe Ala Arg Arg Gln 
65                  70                  75                  80  


Gly Phe Xaa Ser Val Pro Ser Gln Gly Gly Ser Ser Leu Gly Met Ala 
                85                  90                  95      


Gln Arg His Asn Ser Val Arg Ser Tyr Xaa Leu Cys Glu Phe Ala Gln 
            100                 105                 110         


Glu Gln 
        


<210> 7142
<211> 543
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<400> 7142
Met Asp Ala Phe Xaa Gly Ser Gly Leu Lys Arg Lys Phe Asp Asp Val 
1               5                   10                  15      


Asp Val Gly Ser Ser Val Ser Asn Ser Asp Asp Glu Ile Ser Ser Ser 
            20                  25                  30          


Asp Ser Ala Asp Ser Cys Asp Ser Leu Asn Pro Pro Xaa Xaa Ala Ser 
        35                  40                  45              


Phe Xaa Pro Xaa Ser Ile Leu Lys Arg Gln Lys Gln Leu Arg Arg Lys 
    50                  55                  60                  


Asn Val Arg Phe Asp Gln Val Xaa Val Tyr Tyr Phe Ala Arg Arg Gln 
65                  70                  75                  80  


Gly Phe Xaa Ser Val Pro Ser Gln Gly Gly Ser Ser Leu Gly Met Ala 
                85                  90                  95      


Gln Arg His Asn Ser Val Arg Ser Tyr Xaa Leu Cys Glu Phe Ala Gln 
            100                 105                 110         


Glu Gln Glu Val Asn His Arg Glu Ile Leu Arg Glu His Leu Lys Glu 
        115                 120                 125             


Glu Lys Leu His Ala Lys Lys Met Lys Leu Xaa Lys Asn Gly Xaa Val 
    130                 135                 140                 


Glu Ser Val Glu Ala Asp Gly Leu Xaa Leu Asp Asp Val Ser Asp Glu 
145                 150                 155                 160 


Asp Ile Asp Val Glu Asn Val Glu Val Asp Asp Tyr Phe Phe Leu Gln 
                165                 170                 175     


Pro Leu Pro Xaa Lys Arg Arg Arg Ala Leu Leu Arg Ala Ser Gly Val 
            180                 185                 190         


His Arg Ile Asp Ala Glu Glu Lys Gln Glu Leu Arg Ala Ile Arg Leu 
        195                 200                 205             


Ser Arg Glu Glu Cys Gly Cys Asp Cys Arg Leu Tyr Cys Asp Pro Glu 
    210                 215                 220                 


Ala Cys Ala Cys Ser Gln Ala Gly Ile Lys Cys Gln Val Asp Arg Met 
225                 230                 235                 240 


Ser Phe Pro Cys Gly Cys Ser Arg Asp Gly Cys Gly Asn Met Ala Gly 
                245                 250                 255     


Arg Ile Glu Phe Asn Pro Ile Arg Val Arg Xaa His Tyr Leu His Xaa 
            260                 265                 270         


Ile Met Lys Leu Glu Leu Glu Ser Lys Arg Gln Val Ser Arg Pro Ala 
        275                 280                 285             


Ala Pro Asp Glu Glu Pro Ser Pro Xaa Ala Ser Cys Ser Leu Xaa Gly 
    290                 295                 300                 


Ala Gln Gly Ser Glu Xaa Gln Asp Phe Gln Glu Phe Ile Ala Glu Asn 
305                 310                 315                 320 


Glu Xaa Ala Val Met His Leu Gln Ser Ala Glu Glu Leu Glu Arg Leu 
                325                 330                 335     


Lys Ala Glu Glu Asp Ser Ser Gly Ser Ser Ala Ser Leu Asp Ser Ser 
            340                 345                 350         


Ile Glu Ser Leu Gly Val Cys Ile Leu Glu Glu Pro Leu Ala Val Pro 
        355                 360                 365             


Glu Glu Leu Cys Pro Gly Leu Xaa Ala Pro Ile Leu Ile Gln Ala Gln 
    370                 375                 380                 


Leu Pro Pro Gly Ser Ser Val Leu Cys Phe Xaa Glu Asn Ser Asp His 
385                 390                 395                 400 


Pro Xaa Ala Ser Xaa Val Asn Ser Pro Ser Tyr Leu Asn Ser Gly Pro 
                405                 410                 415     


Leu Val Tyr Tyr Gln Val Glu Gln Arg Pro Val Leu Gly Val Lys Gly 
            420                 425                 430         


Glu Pro Gly Xaa Glu Glu Gly Ser Ala Ser Phe Pro Lys Glu Lys Asp 
        435                 440                 445             


Leu Asn Val Phe Ser Leu Pro Val Xaa Ser Leu Val Ala Cys Ser Ser 
    450                 455                 460                 


Xaa Asp Pro Ala Ala Leu Cys Lys Ser Glu Val Gly Lys Xaa Pro Xaa 
465                 470                 475                 480 


Leu Glu Ala Leu Leu Pro Glu Asp Cys Asn Pro Glu Glu Pro Glu Asn 
                485                 490                 495     


Glu Asp Phe His Pro Ser Trp Ser Pro Ser Ser Leu Pro Phe Arg Xaa 
            500                 505                 510         


Asp Asn Glu Glu Gly Cys Gly Met Val Lys Xaa Ser Gln Gln Asn Glu 
        515                 520                 525             


Asp Arg Pro Pro Glu Asp Ser Ser Leu Glu Leu Pro Leu Ala Val 
    530                 535                 540             


<210> 7143
<211> 617
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<400> 7143
Met Lys Cys Ala Leu Phe Leu Arg Val Lys Ile Leu Gln Arg Val Cys 
1               5                   10                  15      


Arg Ser Arg Tyr Ile Val His Ala Gly Xaa Cys Asp Ser Xaa Ala Ala 
            20                  25                  30          


Met Ser Gly Ile Leu Lys Arg Lys Phe Glu Glu Val Asp Gly Ser Ser 
        35                  40                  45              


Pro Cys Ser Ser Val Arg Glu Ser Asp Asp Glu Val Ser Ser Ser Glu 
    50                  55                  60                  


Ser Ala Asp Ser Gly Asp Ser Val Asn Pro Ser Xaa Ser Ser His Phe 
65                  70                  75                  80  


Xaa Pro Ser Ser Ile Leu Lys Arg Glu Lys Arg Leu Arg Xaa Lys Asn 
                85                  90                  95      


Val His Phe Ser Cys Val Xaa Val Tyr Tyr Phe Xaa Arg Arg Gln Gly 
            100                 105                 110         


Phe Xaa Ser Val Pro Ser Gln Gly Gly Ser Xaa Leu Gly Met Ser Ser 
        115                 120                 125             


Arg His Asn Ser Val Arg Gln Tyr Xaa Leu Gly Glu Phe Ala Arg Glu 
    130                 135                 140                 


Gln Glu Arg Leu His Arg Glu Met Leu Arg Glu His Leu Arg Glu Glu 
145                 150                 155                 160 


Lys Leu Asn Ser Leu Lys Leu Lys Met Xaa Lys Asn Gly Xaa Val Glu 
                165                 170                 175     


Ser Glu Glu Ala Ser Xaa Leu Xaa Leu Asp Asp Ile Ser Asp Asp Asp 
            180                 185                 190         


Ile Asp Leu Asp Asn Xaa Glu Val Asp Glu Tyr Phe Phe Leu Gln Pro 
        195                 200                 205             


Leu Pro Xaa Lys Lys Arg Arg Ala Leu Leu Arg Ala Ser Gly Val Lys 
    210                 215                 220                 


Lys Ile Asp Val Glu Glu Lys His Glu Leu Arg Ala Ile Arg Leu Ser 
225                 230                 235                 240 


Arg Glu Asp Cys Gly Cys Asp Cys Arg Val Phe Cys Asp Pro Asp Xaa 
                245                 250                 255     


Cys Xaa Cys Ser Leu Ala Gly Ile Lys Cys Gln Val Asp Arg Met Ser 
            260                 265                 270         


Phe Pro Cys Gly Cys Xaa Lys Glu Gly Cys Ser Asn Xaa Ala Gly Arg 
        275                 280                 285             


Ile Glu Phe Asn Pro Ile Arg Val Arg Xaa His Phe Leu His Xaa Ile 
    290                 295                 300                 


Met Lys Leu Glu Leu Glu Lys Asn Arg Glu Gln Gln Ile Pro Xaa Leu 
305                 310                 315                 320 


Asn Gly Cys His Ser Glu Ile Ser Ala His Ser Ser Ser Met Gly Pro 
                325                 330                 335     


Val Ala His Ser Val Glu Tyr Ser Ile Ala Asp Ser Phe Glu Ile Glu 
            340                 345                 350         


Xaa Glu Pro Gln Ala Ala Val Leu His Leu Gln Ser Ala Glu Glu Leu 
        355                 360                 365             


Asp Cys Gln Gly Glu Glu Glu Glu Glu Glu Glu Asp Gly Ser Ser Phe 
    370                 375                 380                 


Cys Ser Gly Val Xaa Asp Ser Ser Xaa Gln Ser Leu Ala Pro Ser Glu 
385                 390                 395                 400 


Ser Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp 
                405                 410                 415     


Asp Asp Asp Asp Lys Gly Asp Gly Phe Val Glu Gly Leu Gly Xaa His 
            420                 425                 430         


Ala Glu Val Val Pro Leu Pro Ser Val Leu Cys Tyr Ser Asp Gly Xaa 
        435                 440                 445             


Ala Val His Glu Ser His Ala Lys Asn Ala Ser Phe Tyr Ala Asn Ser 
    450                 455                 460                 


Ser Xaa Leu Tyr Tyr Gln Ile Asp Ser His Ile Pro Gly Xaa Pro Asn 
465                 470                 475                 480 


Gln Ile Ser Glu Asn Tyr Ser Glu Arg Asp Xaa Val Lys Asn Gly Xaa 
                485                 490                 495     


Leu Ser Leu Val Pro Tyr Xaa Met Xaa Pro Glu Gln Phe Val Asp Tyr 
            500                 505                 510         


Ala Arg Gln Ala Glu Glu Ala Tyr Gly Ala Ser His Tyr Pro Ala Ala 
        515                 520                 525             


Asn Pro Ser Val Ile Val Cys Cys Ser Ser Ser Glu Asn Asp Ser Gly 
    530                 535                 540                 


Val Pro Cys Asn Ser Leu Tyr Pro Glu His Arg Ser Asn His Pro Gln 
545                 550                 555                 560 


Val Glu Phe His Ser Tyr Leu Lys Gly Pro Ser Gln Glu Gly Phe Val 
                565                 570                 575     


Ser Ala Leu Asn Gly Asp Ser His Ile Ser Glu His Pro Ala Glu Asn 
            580                 585                 590         


Ser Leu Ser Leu Ala Glu Lys Ser Ile Leu His Glu Glu Cys Ile Lys 
        595                 600                 605             


Ser Pro Val Val Glu Xaa Val Pro Val 
    610                 615         


<210> 7144
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<400> 7144
Met Ser Gly Ile Leu Lys Arg Lys Phe Glu Glu Val Asp Gly Ser Ser 
1               5                   10                  15      


Pro Cys Ser Ser Val Arg Glu Ser Asp Asp Glu Val Ser Ser Ser Glu 
            20                  25                  30          


Ser Ala Asp Ser Gly Asp Ser Val Asn Pro Ser Xaa Ser Ser His Phe 
        35                  40                  45              


Xaa Pro Ser Ser Ile Leu Lys Arg Glu Lys Arg Leu Arg Xaa Lys Asn 
    50                  55                  60                  


Val His Phe Ser Cys Val Xaa Val Tyr Tyr Phe Xaa Arg Arg Gln Gly 
65                  70                  75                  80  


Phe Xaa Ser Val Pro Ser Gln Gly Gly Ser Xaa Leu Gly Met Ser Ser 
                85                  90                  95      


Arg His Asn Ser Val Arg Gln Tyr Xaa Leu Gly Glu Phe Ala Arg Glu 
            100                 105                 110         


Gln Glu Arg Leu His Arg Glu Met Leu Arg Glu His Leu Arg Glu Glu 
        115                 120                 125             


Lys Leu Asn Ser Leu Lys Leu Lys Met Xaa 
    130                 135             


<210> 7145
<211> 437
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<400> 7145
Met Ser Gly Ile Leu Lys Arg Lys Phe Glu Glu Val Asp Gly Ser Ser 
1               5                   10                  15      


Pro Cys Ser Ser Val Arg Glu Ser Asp Asp Glu Val Ser Ser Ser Glu 
            20                  25                  30          


Ser Ala Asp Ser Gly Asp Ser Val Asn Pro Ser Xaa Ser Ser His Phe 
        35                  40                  45              


Xaa Pro Ser Ser Ile Leu Lys Arg Glu Lys Arg Leu Arg Xaa Lys Asn 
    50                  55                  60                  


Val His Phe Ser Cys Val Xaa Val Tyr Tyr Phe Xaa Arg Arg Gln Gly 
65                  70                  75                  80  


Phe Xaa Ser Val Pro Ser Gln Gly Gly Ser Xaa Leu Gly Met Ser Ser 
                85                  90                  95      


Arg His Asn Ser Val Arg Gln Tyr Xaa Leu Gly Glu Phe Ala Arg Glu 
            100                 105                 110         


Gln Glu Arg Leu His Arg Glu Met Leu Arg Glu His Leu Arg Glu Glu 
        115                 120                 125             


Lys Leu Asn Ser Leu Lys Leu Lys Met Xaa Lys Asn Gly Xaa Val Glu 
    130                 135                 140                 


Ser Glu Glu Ala Ser Xaa Leu Xaa Leu Asp Asp Ile Ser Asp Asp Asp 
145                 150                 155                 160 


Ile Asp Leu Asp Asn Xaa Glu Val Asp Glu Tyr Phe Phe Leu Gln Pro 
                165                 170                 175     


Leu Pro Xaa Lys Lys Arg Arg Ala Leu Leu Arg Ala Ser Gly Val Lys 
            180                 185                 190         


Lys Ile Asp Val Glu Glu Lys His Glu Leu Arg Ala Ile Arg Leu Ser 
        195                 200                 205             


Arg Glu Asp Cys Gly Cys Asp Cys Arg Val Phe Cys Asp Pro Asp Xaa 
    210                 215                 220                 


Cys Xaa Cys Ser Leu Ala Gly Ile Lys Cys Gln Val Asp Arg Met Ser 
225                 230                 235                 240 


Phe Pro Cys Gly Cys Xaa Lys Glu Gly Cys Ser Asn Xaa Ala Gly Arg 
                245                 250                 255     


Ile Glu Phe Asn Pro Ile Arg Val Arg Xaa His Phe Leu His Xaa Ile 
            260                 265                 270         


Met Lys Leu Glu Leu Glu Lys Asn Arg Glu Gln Gln Ile Pro Xaa Leu 
        275                 280                 285             


Asn Gly Cys His Ser Glu Ile Ser Ala His Ser Ser Ser Met Gly Pro 
    290                 295                 300                 


Val Ala His Ser Val Glu Tyr Ser Ile Ala Asp Ser Phe Glu Ile Glu 
305                 310                 315                 320 


Xaa Glu Pro Gln Ala Ala Val Leu His Leu Gln Ser Ala Glu Glu Leu 
                325                 330                 335     


Asp Cys Gln Gly Glu Glu Glu Glu Glu Glu Glu Asp Gly Ser Ser Phe 
            340                 345                 350         


Cys Ser Gly Val Xaa Asp Ser Ser Xaa Gln Ser Leu Ala Pro Ser Glu 
        355                 360                 365             


Ser Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp 
    370                 375                 380                 


Asp Asp Asp Asp Lys Gly Asp Gly Phe Val Glu Gly Leu Gly Xaa His 
385                 390                 395                 400 


Ala Glu Val Val Pro Leu Pro Ser Val Leu Cys Tyr Ser Asp Gly Xaa 
                405                 410                 415     


Ala Val His Glu Ser His Ala Lys Asn Ala Ser Phe Tyr Ala Asn Ser 
            420                 425                 430         


Ser Xaa Leu Tyr Tyr 
        435         


<210> 7146
<211> 585
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<400> 7146
Met Ser Gly Ile Leu Lys Arg Lys Phe Glu Glu Val Asp Gly Ser Ser 
1               5                   10                  15      


Pro Cys Ser Ser Val Arg Glu Ser Asp Asp Glu Val Ser Ser Ser Glu 
            20                  25                  30          


Ser Ala Asp Ser Gly Asp Ser Val Asn Pro Ser Xaa Ser Ser His Phe 
        35                  40                  45              


Xaa Pro Ser Ser Ile Leu Lys Arg Glu Lys Arg Leu Arg Xaa Lys Asn 
    50                  55                  60                  


Val His Phe Ser Cys Val Xaa Val Tyr Tyr Phe Xaa Arg Arg Gln Gly 
65                  70                  75                  80  


Phe Xaa Ser Val Pro Ser Gln Gly Gly Ser Xaa Leu Gly Met Ser Ser 
                85                  90                  95      


Arg His Asn Ser Val Arg Gln Tyr Xaa Leu Gly Glu Phe Ala Arg Glu 
            100                 105                 110         


Gln Glu Arg Leu His Arg Glu Met Leu Arg Glu His Leu Arg Glu Glu 
        115                 120                 125             


Lys Leu Asn Ser Leu Lys Leu Lys Met Xaa Lys Asn Gly Xaa Val Glu 
    130                 135                 140                 


Ser Glu Glu Ala Ser Xaa Leu Xaa Leu Asp Asp Ile Ser Asp Asp Asp 
145                 150                 155                 160 


Ile Asp Leu Asp Asn Xaa Glu Val Asp Glu Tyr Phe Phe Leu Gln Pro 
                165                 170                 175     


Leu Pro Xaa Lys Lys Arg Arg Ala Leu Leu Arg Ala Ser Gly Val Lys 
            180                 185                 190         


Lys Ile Asp Val Glu Glu Lys His Glu Leu Arg Ala Ile Arg Leu Ser 
        195                 200                 205             


Arg Glu Asp Cys Gly Cys Asp Cys Arg Val Phe Cys Asp Pro Asp Xaa 
    210                 215                 220                 


Cys Xaa Cys Ser Leu Ala Gly Ile Lys Cys Gln Val Asp Arg Met Ser 
225                 230                 235                 240 


Phe Pro Cys Gly Cys Xaa Lys Glu Gly Cys Ser Asn Xaa Ala Gly Arg 
                245                 250                 255     


Ile Glu Phe Asn Pro Ile Arg Val Arg Xaa His Phe Leu His Xaa Ile 
            260                 265                 270         


Met Lys Leu Glu Leu Glu Lys Asn Arg Glu Gln Gln Ile Pro Xaa Leu 
        275                 280                 285             


Asn Gly Cys His Ser Glu Ile Ser Ala His Ser Ser Ser Met Gly Pro 
    290                 295                 300                 


Val Ala His Ser Val Glu Tyr Ser Ile Ala Asp Ser Phe Glu Ile Glu 
305                 310                 315                 320 


Xaa Glu Pro Gln Ala Ala Val Leu His Leu Gln Ser Ala Glu Glu Leu 
                325                 330                 335     


Asp Cys Gln Gly Glu Glu Glu Glu Glu Glu Glu Asp Gly Ser Ser Phe 
            340                 345                 350         


Cys Ser Gly Val Xaa Asp Ser Ser Xaa Gln Ser Leu Ala Pro Ser Glu 
        355                 360                 365             


Ser Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp 
    370                 375                 380                 


Asp Asp Asp Asp Lys Gly Asp Gly Phe Val Glu Gly Leu Gly Xaa His 
385                 390                 395                 400 


Ala Glu Val Val Pro Leu Pro Ser Val Leu Cys Tyr Ser Asp Gly Xaa 
                405                 410                 415     


Ala Val His Glu Ser His Ala Lys Asn Ala Ser Phe Tyr Ala Asn Ser 
            420                 425                 430         


Ser Xaa Leu Tyr Tyr Gln Ile Asp Ser His Ile Pro Gly Xaa Pro Asn 
        435                 440                 445             


Gln Ile Ser Glu Asn Tyr Ser Glu Arg Asp Xaa Val Lys Asn Gly Xaa 
    450                 455                 460                 


Leu Ser Leu Val Pro Tyr Xaa Met Xaa Pro Glu Gln Phe Val Asp Tyr 
465                 470                 475                 480 


Ala Arg Gln Ala Glu Glu Ala Tyr Gly Ala Ser His Tyr Pro Ala Ala 
                485                 490                 495     


Asn Pro Ser Val Ile Val Cys Cys Ser Ser Ser Glu Asn Asp Ser Gly 
            500                 505                 510         


Val Pro Cys Asn Ser Leu Tyr Pro Glu His Arg Ser Asn His Pro Gln 
        515                 520                 525             


Val Glu Phe His Ser Tyr Leu Lys Gly Pro Ser Gln Glu Gly Phe Val 
    530                 535                 540                 


Ser Ala Leu Asn Gly Asp Ser His Ile Ser Glu His Pro Ala Glu Asn 
545                 550                 555                 560 


Ser Leu Ser Leu Ala Glu Lys Ser Ile Leu His Glu Glu Cys Ile Lys 
                565                 570                 575     


Ser Pro Val Val Glu Xaa Val Pro Val 
            580                 585 


<210> 7147
<211> 69
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<400> 7147
Ala Pro Ser Gly Gly Gly His Gly Val Phe Pro Ala His His Gln Glu 
1               5                   10                  15      


Val Asp Xaa Arg Phe Val Leu Ser Pro Ile Arg Arg Trp Xaa Leu Gly 
            20                  25                  30          


Leu Pro Cys Ala Pro Ser Gly Gly Gly His Ser Val Tyr Pro Glu Pro 
        35                  40                  45              


His Gln Glu Val Asp Xaa Arg Phe Ala Leu Cys Pro Ile Arg Arg Trp 
    50                  55                  60                  


Xaa Leu Gly Phe Ser 
65                  


<210> 7148
<211> 187
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<400> 7148
Met Cys Arg Arg Leu Ser Asp Gly Val Arg Pro Pro Ile Met Asn Gly 
1               5                   10                  15      


Pro Leu His Pro Arg Pro Leu Val Ala Leu Leu Asp Gly Arg Asp Cys 
            20                  25                  30          


Xaa Val Glu Met Pro Ile Leu Lys Asp Val Ala Xaa Val Ala Phe Cys 
        35                  40                  45              


Asp Ala Gln Ser Xaa Gln Glu Ile His Glu Lys Val Leu Asn Glu Ala 
    50                  55                  60                  


Val Gly Ala Leu Met Tyr His Xaa Ile Xaa Leu Xaa Arg Glu Asp Leu 
65                  70                  75                  80  


Glu Lys Phe Lys Ala Leu Arg Ile Ile Val Arg Ile Gly Ser Gly Phe 
                85                  90                  95      


Asp Asn Ile Asp Ile Lys Ser Ala Gly Asp Leu Gly Ile Ala Val Cys 
            100                 105                 110         


Asn Val Pro Ala Ala Ser Val Glu Glu Xaa Ala Asp Ser Xaa Leu Cys 
        115                 120                 125             


His Ile Leu Asn Leu Tyr Arg Arg Ala Xaa Trp Leu His Gln Ala Leu 
    130                 135                 140                 


Arg Glu Gly Xaa Arg Val Gln Ser Val Glu Gln Ile Arg Glu Val Ala 
145                 150                 155                 160 


Ser Gly Ala Ala Arg Ile Arg Gly Glu Xaa Leu Gly Ile Ile Gly Leu 
                165                 170                 175     


Gly Arg Val Gly Gln Ala Val Ala Leu Arg Ala 
            180                 185         


<210> 7149
<211> 440
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<400> 7149
Met Gly Ser Ser His Leu Leu Asn Lys Gly Leu Pro Leu Gly Val Arg 
1               5                   10                  15      


Pro Pro Ile Met Asn Gly Pro Leu His Pro Arg Pro Leu Val Ala Leu 
            20                  25                  30          


Leu Asp Gly Arg Asp Cys Xaa Val Glu Met Pro Ile Leu Lys Asp Val 
        35                  40                  45              


Ala Xaa Val Ala Phe Cys Asp Ala Gln Ser Xaa Gln Glu Ile His Glu 
    50                  55                  60                  


Lys Val Leu Asn Glu Ala Val Gly Ala Leu Met Tyr His Xaa Ile Xaa 
65                  70                  75                  80  


Leu Xaa Arg Glu Asp Leu Glu Lys Phe Lys Ala Leu Arg Ile Ile Val 
                85                  90                  95      


Arg Ile Gly Ser Gly Phe Asp Asn Ile Asp Ile Lys Ser Ala Gly Asp 
            100                 105                 110         


Leu Gly Ile Ala Val Cys Asn Val Pro Ala Ala Ser Val Glu Glu Xaa 
        115                 120                 125             


Ala Asp Ser Xaa Leu Cys His Ile Leu Asn Leu Tyr Arg Arg Ala Xaa 
    130                 135                 140                 


Trp Leu His Gln Ala Leu Arg Glu Gly Xaa Arg Val Gln Ser Val Glu 
145                 150                 155                 160 


Gln Ile Arg Glu Val Ala Ser Gly Ala Ala Arg Ile Arg Gly Glu Xaa 
                165                 170                 175     


Leu Gly Ile Ile Gly Leu Gly Arg Val Gly Gln Ala Val Ala Leu Arg 
            180                 185                 190         


Ala Lys Ala Phe Gly Phe Asn Val Leu Phe Tyr Asp Pro Tyr Leu Ser 
        195                 200                 205             


Asp Gly Val Glu Arg Ala Leu Gly Leu Gln Arg Val Ser Xaa Leu Gln 
    210                 215                 220                 


Asp Leu Leu Phe His Ser Asp Cys Val Xaa Leu His Cys Gly Leu Asn 
225                 230                 235                 240 


Glu His Asn His His Leu Ile Asn Asp Phe Xaa Val Lys Gln Met Arg 
                245                 250                 255     


Gln Gly Ala Phe Leu Val Asn Xaa Ala Arg Gly Gly Leu Val Asp Glu 
            260                 265                 270         


Lys Ala Leu Ala Gln Ala Leu Lys Glu Gly Arg Ile Arg Gly Ala Ala 
        275                 280                 285             


Leu Asp Val His Glu Ser Glu Pro Phe Ser Phe Ser Gln Gly Pro Leu 
    290                 295                 300                 


Lys Asp Ala Pro Asn Leu Ile Cys Xaa Pro His Ala Ala Trp Tyr Ser 
305                 310                 315                 320 


Glu Gln Ala Ser Ile Glu Met Arg Glu Glu Ala Ala Arg Glu Ile Arg 
                325                 330                 335     


Arg Ala Ile Xaa Gly Arg Ile Pro Asp Ser Leu Lys Asn Cys Val Asn 
            340                 345                 350         


Lys Asp His Leu Xaa Ala Ala Xaa His Trp Ala Ser Met Asp Pro Ala 
        355                 360                 365             


Val Val His Pro Glu Leu Asn Gly Ala Ala Tyr Arg Tyr Pro Pro Gly 
    370                 375                 380                 


Val Val Gly Val Ala Pro Xaa Gly Ile Pro Ala Ala Val Glu Gly Ile 
385                 390                 395                 400 


Val Pro Ser Ala Met Ser Leu Ser His Gly Leu Pro Pro Val Ala His 
                405                 410                 415     


Pro Pro His Ala Pro Ser Pro Gly Gln Xaa Val Lys Pro Glu Ala Asp 
            420                 425                 430         


Arg Asp His Ala Ser Asp Gln Leu 
        435                 440 


<210> 7150
<211> 145
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<400> 7150
Met Ser Gly Val Arg Pro Pro Ile Met Asn Gly Pro Leu His Pro Arg 
1               5                   10                  15      


Pro Leu Val Ala Leu Leu Asp Gly Arg Asp Cys Xaa Val Glu Met Pro 
            20                  25                  30          


Ile Leu Lys Asp Val Ala Xaa Val Ala Phe Cys Asp Ala Gln Ser Xaa 
        35                  40                  45              


Gln Glu Ile His Glu Lys Val Leu Asn Glu Ala Val Gly Ala Leu Met 
    50                  55                  60                  


Tyr His Xaa Ile Xaa Leu Xaa Arg Glu Asp Leu Glu Lys Phe Lys Ala 
65                  70                  75                  80  


Leu Arg Ile Ile Val Arg Ile Gly Ser Gly Phe Asp Asn Ile Asp Ile 
                85                  90                  95      


Lys Ser Ala Gly Asp Leu Gly Ile Ala Val Cys Asn Val Pro Ala Ala 
            100                 105                 110         


Ser Val Glu Glu Xaa Ala Asp Ser Xaa Leu Cys His Ile Leu Asn Leu 
        115                 120                 125             


Tyr Arg Arg Ala Xaa Trp Leu His Gln Ala Leu Arg Glu Gly Xaa Arg 
    130                 135                 140                 


Val 
145 


<210> 7151
<211> 171
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<400> 7151
Met Ser Gly Val Arg Pro Pro Ile Met Asn Gly Pro Leu His Pro Arg 
1               5                   10                  15      


Pro Leu Val Ala Leu Leu Asp Gly Arg Asp Cys Xaa Val Glu Met Pro 
            20                  25                  30          


Ile Leu Lys Asp Val Ala Xaa Val Ala Phe Cys Asp Ala Gln Ser Xaa 
        35                  40                  45              


Gln Glu Ile His Glu Lys Val Leu Asn Glu Ala Val Gly Ala Leu Met 
    50                  55                  60                  


Tyr His Xaa Ile Xaa Leu Xaa Arg Glu Asp Leu Glu Lys Phe Lys Ala 
65                  70                  75                  80  


Leu Arg Ile Ile Val Arg Ile Gly Ser Gly Phe Asp Asn Ile Asp Ile 
                85                  90                  95      


Lys Ser Ala Gly Asp Leu Gly Ile Ala Val Cys Asn Val Pro Ala Ala 
            100                 105                 110         


Ser Val Glu Glu Xaa Ala Asp Ser Xaa Leu Cys His Ile Leu Asn Leu 
        115                 120                 125             


Tyr Arg Arg Ala Xaa Trp Leu His Gln Ala Leu Arg Glu Gly Xaa Arg 
    130                 135                 140                 


Val Gln Ser Val Glu Gln Ile Arg Glu Val Ala Ser Gly Ala Ala Arg 
145                 150                 155                 160 


Ile Arg Gly Glu Xaa Leu Gly Ile Ile Gly Leu 
                165                 170     


<210> 7152
<211> 429
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<400> 7152
Met Ser Gly Val Arg Pro Pro Ile Met Asn Gly Pro Leu His Pro Arg 
1               5                   10                  15      


Pro Leu Val Ala Leu Leu Asp Gly Arg Asp Cys Xaa Val Glu Met Pro 
            20                  25                  30          


Ile Leu Lys Asp Val Ala Xaa Val Ala Phe Cys Asp Ala Gln Ser Xaa 
        35                  40                  45              


Gln Glu Ile His Glu Lys Val Leu Asn Glu Ala Val Gly Ala Leu Met 
    50                  55                  60                  


Tyr His Xaa Ile Xaa Leu Xaa Arg Glu Asp Leu Glu Lys Phe Lys Ala 
65                  70                  75                  80  


Leu Arg Ile Ile Val Arg Ile Gly Ser Gly Phe Asp Asn Ile Asp Ile 
                85                  90                  95      


Lys Ser Ala Gly Asp Leu Gly Ile Ala Val Cys Asn Val Pro Ala Ala 
            100                 105                 110         


Ser Val Glu Glu Xaa Ala Asp Ser Xaa Leu Cys His Ile Leu Asn Leu 
        115                 120                 125             


Tyr Arg Arg Ala Xaa Trp Leu His Gln Ala Leu Arg Glu Gly Xaa Arg 
    130                 135                 140                 


Val Gln Ser Val Glu Gln Ile Arg Glu Val Ala Ser Gly Ala Ala Arg 
145                 150                 155                 160 


Ile Arg Gly Glu Xaa Leu Gly Ile Ile Gly Leu Gly Arg Val Gly Gln 
                165                 170                 175     


Ala Val Ala Leu Arg Ala Lys Ala Phe Gly Phe Asn Val Leu Phe Tyr 
            180                 185                 190         


Asp Pro Tyr Leu Ser Asp Gly Val Glu Arg Ala Leu Gly Leu Gln Arg 
        195                 200                 205             


Val Ser Xaa Leu Gln Asp Leu Leu Phe His Ser Asp Cys Val Xaa Leu 
    210                 215                 220                 


His Cys Gly Leu Asn Glu His Asn His His Leu Ile Asn Asp Phe Xaa 
225                 230                 235                 240 


Val Lys Gln Met Arg Gln Gly Ala Phe Leu Val Asn Xaa Ala Arg Gly 
                245                 250                 255     


Gly Leu Val Asp Glu Lys Ala Leu Ala Gln Ala Leu Lys Glu Gly Arg 
            260                 265                 270         


Ile Arg Gly Ala Ala Leu Asp Val His Glu Ser Glu Pro Phe Ser Phe 
        275                 280                 285             


Ser Gln Gly Pro Leu Lys Asp Ala Pro Asn Leu Ile Cys Xaa Pro His 
    290                 295                 300                 


Ala Ala Trp Tyr Ser Glu Gln Ala Ser Ile Glu Met Arg Glu Glu Ala 
305                 310                 315                 320 


Ala Arg Glu Ile Arg Arg Ala Ile Xaa Gly Arg Ile Pro Asp Ser Leu 
                325                 330                 335     


Lys Asn Cys Val Asn Lys Asp His Leu Xaa Ala Ala Xaa His Trp Ala 
            340                 345                 350         


Ser Met Asp Pro Ala Val Val His Pro Glu Leu Asn Gly Ala Ala Tyr 
        355                 360                 365             


Arg Tyr Pro Pro Gly Val Val Gly Val Ala Pro Xaa Gly Ile Pro Ala 
    370                 375                 380                 


Ala Val Glu Gly Ile Val Pro Ser Ala Met Ser Leu Ser His Gly Leu 
385                 390                 395                 400 


Pro Pro Val Ala His Pro Pro His Ala Pro Ser Pro Gly Gln Xaa Val 
                405                 410                 415     


Lys Pro Glu Ala Asp Arg Asp His Ala Ser Asp Gln Leu 
            420                 425                 


<210> 7153
<211> 202
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<400> 7153
Met Ser Gly Val Arg Pro Pro Ile Met Asn Gly Pro Leu His Pro Arg 
1               5                   10                  15      


Pro Leu Val Ala Leu Leu Asp Gly Arg Asp Cys Xaa Val Glu Met Pro 
            20                  25                  30          


Ile Leu Lys Asp Val Ala Xaa Val Ala Phe Cys Asp Ala Gln Ser Xaa 
        35                  40                  45              


Gln Glu Ile His Glu Lys Val Leu Asn Glu Ala Val Gly Ala Leu Met 
    50                  55                  60                  


Tyr His Xaa Ile Xaa Leu Xaa Arg Glu Asp Leu Glu Lys Phe Lys Ala 
65                  70                  75                  80  


Leu Arg Ile Ile Val Arg Ile Gly Ser Gly Phe Asp Asn Ile Asp Ile 
                85                  90                  95      


Lys Ser Ala Gly Asp Leu Gly Ile Ala Val Cys Asn Val Pro Ala Ala 
            100                 105                 110         


Ser Val Glu Glu Xaa Ala Asp Ser Xaa Leu Cys His Ile Leu Asn Leu 
        115                 120                 125             


Tyr Arg Arg Ala Xaa Trp Leu His Gln Ala Leu Arg Glu Gly Xaa Arg 
    130                 135                 140                 


Val Gln Ser Val Glu Gln Ile Arg Glu Val Ala Ser Gly Ala Ala Arg 
145                 150                 155                 160 


Ile Arg Gly Glu Xaa Leu Gly Ile Ile Gly Leu Gly Ser Pro Leu Leu 
                165                 170                 175     


Leu Xaa Ala Val Leu Val Pro Pro Ala Phe Gly Glu Ser Asp Val Ser 
            180                 185                 190         


Gly Gly Leu Gly Glu Ala Ala Xaa Pro Arg 
        195                 200         


<210> 7154
<211> 168
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<400> 7154
Met Ser Gly Val Arg Pro Pro Ile Met Asn Gly Pro Leu His Pro Arg 
1               5                   10                  15      


Pro Leu Val Ala Leu Leu Asp Gly Arg Asp Cys Xaa Val Glu Met Pro 
            20                  25                  30          


Ile Leu Lys Asp Val Ala Xaa Val Ala Phe Cys Asp Ala Gln Ser Xaa 
        35                  40                  45              


Gln Glu Ile His Glu Lys Val Pro Pro Arg Gly Arg Leu Gly Leu Ala 
    50                  55                  60                  


Glu Pro His Val Gly Gly Ser Trp Arg Asp Gly Ser Xaa Ala Gly Pro 
65                  70                  75                  80  


Gly His Ser Arg Ser Gly Cys His Trp Gly Arg Ser Ser Leu Cys Pro 
                85                  90                  95      


Ser Arg Pro Ala Pro Ser Gly Gly Gly His Gly Val Phe Pro Gly His 
            100                 105                 110         


His Gln Glu Val Asp Ile Gly Phe Ala Leu Ser Pro Ile Arg Arg Trp 
        115                 120                 125             


Xaa Arg Gly Phe Pro Cys Ala Pro Ser Gly Gly Gly His His Val Cys 
    130                 135                 140                 


Pro Glu Pro His Gln Glu Val Asp Ile Arg Phe Ala Leu Cys Pro Ile 
145                 150                 155                 160 


Arg Arg Trp Xaa Arg Gly Phe Pro 
                165             


<210> 7155
<211> 184
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<400> 7155
Xaa Ala Phe Leu Val Asn Xaa Ala Arg Gly Gly Leu Val Asp Glu Lys 
1               5                   10                  15      


Ala Leu Ala Gln Ala Leu Lys Glu Gly Arg Ile Arg Gly Ala Ala Leu 
            20                  25                  30          


Asp Val His Glu Ser Glu Pro Phe Ser Phe Ser Gln Gly Pro Leu Lys 
        35                  40                  45              


Asp Ala Pro Asn Leu Ile Cys Xaa Pro His Ala Ala Trp Tyr Ser Glu 
    50                  55                  60                  


Gln Ala Ser Ile Glu Met Arg Glu Glu Ala Ala Arg Glu Ile Arg Arg 
65                  70                  75                  80  


Ala Ile Xaa Gly Arg Ile Pro Asp Ser Leu Lys Asn Cys Val Asn Lys 
                85                  90                  95      


Asp His Leu Xaa Ala Ala Xaa His Trp Ala Ser Met Asp Pro Ala Val 
            100                 105                 110         


Val His Pro Glu Leu Asn Gly Ala Ala Tyr Ser Arg Tyr Pro Pro Gly 
        115                 120                 125             


Val Val Gly Val Ala Pro Xaa Gly Ile Pro Ala Ala Val Glu Gly Ile 
    130                 135                 140                 


Val Pro Ser Ala Met Ser Leu Ser His Gly Leu Pro Pro Val Ala His 
145                 150                 155                 160 


Pro Pro His Ala Pro Ser Pro Gly Gln Xaa Val Lys Pro Glu Ala Asp 
                165                 170                 175     


Arg Asp His Ala Ser Asp Gln Leu 
            180                 


<210> 7156
<211> 145
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 7156
Xaa Gly Glu Xaa Leu Gly Ile Ile Gly Leu Gly Arg Val Gly Gln Ala 
1               5                   10                  15      


Val Ala Leu Arg Ala Lys Ala Phe Gly Phe Asn Val Leu Phe Tyr Asp 
            20                  25                  30          


Pro Tyr Leu Ser Asp Gly Val Glu Arg Ala Leu Gly Leu Gln Arg Val 
        35                  40                  45              


Ser Xaa Leu Gln Asp Leu Leu Phe His Ser Asp Cys Val Xaa Leu His 
    50                  55                  60                  


Cys Gly Leu Asn Glu His Asn His His Leu Ile Asn Asp Phe Xaa Val 
65                  70                  75                  80  


Lys Gln Met Arg Gln Gly Ala Phe Leu Val Asn Xaa Ala Arg Gly Gly 
                85                  90                  95      


Leu Val Asp Glu Lys Ala Leu Ala Gln Ala Leu Lys Glu Gly Arg Ile 
            100                 105                 110         


Arg Gly Ala Ala Leu Asp Val His Glu Ser Glu Pro Phe Arg Cys Pro 
        115                 120                 125             


His Gly Gln Cys Arg Pro Pro Ala Leu Pro Cys Pro Pro Ser Cys Arg 
    130                 135                 140                 


Pro 
145 


<210> 7157
<211> 24
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<400> 7157
Xaa Ile Arg Gly Glu Xaa Leu Gly Ile Ile Gly Leu Gly Ala His Arg 
1               5                   10                  15      


Lys Xaa Leu Tyr Xaa Phe Xaa Pro 
            20                  


<210> 7158
<211> 287
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<400> 7158
Xaa Leu Glu Lys Phe Lys Ala Leu Arg Ile Ile Val Arg Ile Gly Ser 
1               5                   10                  15      


Gly Phe Asp Asn Ile Asp Ile Lys Ser Ala Gly Asp Leu Gly Arg Val 
            20                  25                  30          


Gly Gln Ala Val Ala Leu Arg Ala Lys Ala Phe Gly Phe Asn Val Leu 
        35                  40                  45              


Phe Tyr Asp Pro Tyr Leu Ser Asp Gly Val Glu Arg Ala Leu Gly Leu 
    50                  55                  60                  


Gln Arg Val Ser Xaa Leu Gln Asp Leu Leu Phe His Ser Asp Cys Val 
65                  70                  75                  80  


Xaa Leu His Cys Gly Leu Asn Glu His Asn His His Leu Ile Asn Asp 
                85                  90                  95      


Phe Xaa Val Lys Gln Met Arg Gln Gly Ala Phe Leu Val Asn Xaa Ala 
            100                 105                 110         


Arg Gly Gly Leu Val Asp Glu Lys Ala Leu Ala Gln Ala Leu Lys Glu 
        115                 120                 125             


Gly Arg Ile Arg Gly Ala Ala Leu Asp Val His Glu Ser Glu Pro Phe 
    130                 135                 140                 


Ser Phe Ser Gln Gly Pro Leu Lys Asp Ala Pro Asn Leu Ile Cys Xaa 
145                 150                 155                 160 


Pro His Ala Ala Trp Tyr Ser Glu Gln Ala Ser Ile Glu Met Arg Glu 
                165                 170                 175     


Glu Ala Ala Arg Glu Ile Arg Arg Ala Ile Xaa Gly Arg Ile Pro Asp 
            180                 185                 190         


Ser Leu Lys Asn Cys Val Asn Lys Asp His Leu Xaa Ala Ala Xaa His 
        195                 200                 205             


Trp Ala Ser Met Asp Pro Ala Val Val His Pro Glu Leu Asn Gly Ala 
    210                 215                 220                 


Ala Tyr Arg Tyr Pro Pro Gly Val Val Gly Val Ala Pro Xaa Gly Ile 
225                 230                 235                 240 


Pro Ala Ala Val Glu Gly Ile Val Pro Ser Ala Met Ser Leu Ser His 
                245                 250                 255     


Gly Leu Pro Pro Val Ala His Pro Pro His Ala Pro Ser Pro Gly Gln 
            260                 265                 270         


Xaa Val Lys Pro Glu Ala Asp Arg Asp His Ala Ser Asp Gln Leu 
        275                 280                 285         


<210> 7159
<211> 445
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<400> 7159
Met Ala Leu Val Asp Lys His Lys Val Lys Arg Gln Arg Leu Asp Arg 
1               5                   10                  15      


Ile Cys Glu Gly Ile Arg Pro Gln Ile Met Asn Gly Pro Leu His Pro 
            20                  25                  30          


Arg Pro Leu Val Ala Leu Leu Asp Gly Arg Asp Cys Xaa Val Glu Met 
        35                  40                  45              


Pro Ile Leu Lys Asp Leu Ala Xaa Val Ala Phe Cys Asp Ala Gln Ser 
    50                  55                  60                  


Xaa Gln Glu Ile His Glu Lys Val Leu Asn Glu Ala Val Gly Ala Met 
65                  70                  75                  80  


Met Tyr His Xaa Ile Xaa Leu Xaa Arg Glu Asp Leu Glu Lys Phe Lys 
                85                  90                  95      


Ala Leu Arg Val Ile Val Arg Ile Gly Ser Gly Tyr Asp Asn Val Asp 
            100                 105                 110         


Ile Lys Ala Ala Gly Glu Leu Gly Ile Ala Val Cys Asn Ile Pro Ser 
        115                 120                 125             


Ala Ala Val Glu Glu Xaa Ala Asp Ser Xaa Ile Cys His Ile Leu Asn 
    130                 135                 140                 


Leu Tyr Arg Arg Asn Xaa Trp Leu Tyr Gln Ala Leu Arg Glu Gly Xaa 
145                 150                 155                 160 


Arg Val Gln Ser Val Glu Gln Ile Arg Glu Val Ala Ser Gly Ala Ala 
                165                 170                 175     


Arg Ile Arg Gly Glu Xaa Leu Gly Leu Ile Gly Phe Gly Arg Xaa Gly 
            180                 185                 190         


Gln Ala Val Ala Val Arg Ala Lys Ala Phe Gly Phe Ser Val Ile Phe 
        195                 200                 205             


Tyr Asp Pro Tyr Leu Gln Asp Gly Ile Glu Arg Ser Leu Gly Val Gln 
    210                 215                 220                 


Arg Val Tyr Xaa Leu Gln Asp Leu Leu Tyr Gln Ser Asp Cys Val Ser 
225                 230                 235                 240 


Leu His Cys Asn Leu Asn Glu His Asn His His Leu Ile Asn Asp Phe 
                245                 250                 255     


Xaa Ile Lys Gln Met Arg Gln Gly Ala Phe Leu Val Asn Ala Ala Arg 
            260                 265                 270         


Gly Gly Leu Val Asp Glu Lys Ala Leu Ala Gln Ala Leu Lys Glu Gly 
        275                 280                 285             


Arg Ile Arg Gly Ala Ala Leu Asp Val His Glu Ser Glu Pro Phe Ser 
    290                 295                 300                 


Phe Ala Gln Gly Pro Leu Lys Asp Ala Pro Asn Leu Ile Cys Xaa Pro 
305                 310                 315                 320 


His Xaa Ala Trp Tyr Ser Glu Gln Ala Ser Leu Glu Met Arg Glu Ala 
                325                 330                 335     


Ala Ala Xaa Glu Ile Arg Arg Ala Ile Xaa Gly Arg Ile Pro Glu Ser 
            340                 345                 350         


Leu Arg Asn Cys Val Asn Lys Glu Phe Phe Val Xaa Ser Ala Pro Trp 
        355                 360                 365             


Ser Val Ile Asp Gln Gln Ala Ile His Pro Glu Leu Asn Gly Ala Xaa 
    370                 375                 380                 


Tyr Arg Tyr Pro Pro Gly Ile Val Gly Val Ala Pro Gly Gly Leu Pro 
385                 390                 395                 400 


Ala Ala Met Glu Gly Ile Ile Pro Gly Gly Ile Pro Val Xaa His Asn 
                405                 410                 415     


Leu Pro Xaa Val Ala His Pro Ser Gln Ala Pro Ser Pro Asn Gln Pro 
            420                 425                 430         


Xaa Lys His Gly Asp Asn Arg Glu His Pro Asn Glu Gln 
        435                 440                 445 


<210> 7160
<211> 985
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (973)..(973)
<223> Selenocysteine

<400> 7160
Met Pro Val Pro Ser Arg His Ile Asn Ile Gly Arg Ser Gln Ser Trp 
1               5                   10                  15      


Asp Ala Ala Gly Trp Tyr Glu Gly Pro Trp Glu Asn Ala Glu Ser Leu 
            20                  25                  30          


Arg Pro Leu Gly Arg Arg Ser Ser Leu Xaa Tyr Gly Xaa Ala Glu Gly 
        35                  40                  45              


Xaa Trp Phe Glu Pro Asn His Arg Pro Gln Asp Ala Ala Leu Pro Val 
    50                  55                  60                  


Ala Ala Glu Pro Tyr Leu Tyr Arg Glu Ala Val Tyr Asn Ser Val Ala 
65                  70                  75                  80  


Ala Arg Lys Gly Ser Xaa Pro Asp Phe Xaa Phe Tyr Asp Ser Arg Gln 
                85                  90                  95      


Ala Val Met Ser Gly Arg Ser Pro Leu Leu Pro Arg Glu Tyr Tyr Ser 
            100                 105                 110         


Asp Pro Ser Gly Ala Ala Arg Val Pro Lys Glu Pro Pro Leu Tyr Arg 
        115                 120                 125             


Asp Pro Gly Val Ser Arg Pro Val Pro Ser Tyr Gly Val Leu Gly Ser 
    130                 135                 140                 


Arg Xaa Ser Trp Asp Pro Met Gln Gly Arg Ser Pro Ala Leu Gln Asp 
145                 150                 155                 160 


Ala Gly His Leu Tyr Arg Asp Pro Gly Gly Lys Met Ile Pro Gln Gly 
                165                 170                 175     


Arg Gln Xaa Gln Ser Arg Ala Ala Ser Pro Gly Arg Tyr Gly Arg Glu 
            180                 185                 190         


Gln Pro Asp Xaa Arg Tyr Gly Ala Glu Val Pro Ala Tyr Pro Leu Ser 
        195                 200                 205             


Gln Val Phe Ser Asp Ile Ser Glu Arg Pro Ile Asp Pro Ala Pro Ala 
    210                 215                 220                 


Arg Gln Val Ala Pro Xaa Cys Leu Val Val Asp Pro Ser Ser Ala Ala 
225                 230                 235                 240 


Ala Pro Glu Gly Ser Xaa Gly Val Ala Pro Gly Ala Leu Asn Arg Gly 
                245                 250                 255     


Tyr Gly Pro Ala Arg Glu Ser Ile Pro Ser Lys Met Ala Tyr Glu Xaa 
            260                 265                 270         


Tyr Glu Ala Asp Leu Ser Xaa Phe Gln Gly Pro Gly Gly Lys Arg Xaa 
        275                 280                 285             


Val Leu Pro Glu Phe Leu Ala Phe Leu Arg Ala Glu Gly Leu Ala Glu 
    290                 295                 300                 


Ala Xaa Leu Gly Ala Leu Leu Gln Gln Gly Phe Asp Ser Pro Ala Val 
305                 310                 315                 320 


Leu Ala Xaa Leu Glu Asp Ala Asp Ile Lys Ser Val Ala Pro Asn Leu 
                325                 330                 335     


Gly Gln Ala Arg Val Leu Ser Arg Leu Ala Asn Ser Cys Arg Xaa Glu 
            340                 345                 350         


Met Gln Leu Arg Arg Gln Asp Arg Gly Gly Pro Leu Pro Arg Ala Arg 
        355                 360                 365             


Ser Ser Ser Phe Ser His Arg Ser Glu Leu Leu His Gly Asp Leu Ala 
    370                 375                 380                 


Ser Leu Gly Ala Ala Ala Pro Leu Gln Xaa Ala Ser Pro Arg Ala Gly 
385                 390                 395                 400 


Asp Pro Ala Arg Arg Pro Ser Ser Ala Pro Ser Gln His Leu Leu Glu 
                405                 410                 415     


Xaa Ala Ala Xaa Tyr Ser Ala Pro Gly Val Gly Xaa His Ala Pro His 
            420                 425                 430         


Phe Pro Ser Asn Ser Gly Tyr Ser Ser Pro Xaa Pro Cys Ala Leu Xaa 
        435                 440                 445             


Ala Arg Leu Ser Pro Xaa Tyr Pro Leu Gln Ala Gly Val Ala Leu Xaa 
    450                 455                 460                 


Asn Pro Gly Pro Ser Asn Pro Leu His Pro Gly Pro Arg Xaa Ala Tyr 
465                 470                 475                 480 


Ser Xaa Ala Tyr Xaa Val Pro Met Glu Leu Leu Lys Arg Glu Arg Asn 
                485                 490                 495     


Val Ala Ala Ser Pro Leu Pro Ser Pro His Gly Ser Pro Gln Val Leu 
            500                 505                 510         


Arg Lys Pro Gly Ala Pro Leu Gly Pro Ser Xaa Leu Pro Pro Ala Ser 
        515                 520                 525             


Gln Ser Leu His Xaa Pro His Ser Pro Tyr Gln Lys Val Ala Arg Arg 
    530                 535                 540                 


Xaa Gly Ala Pro Ile Ile Val Ser Xaa Met Leu Ala Pro Glu Pro Ser 
545                 550                 555                 560 


Ile Arg Pro Gln Ile Met Asn Gly Pro Leu His Pro Arg Pro Leu Val 
                565                 570                 575     


Ala Leu Leu Asp Gly Arg Asp Cys Xaa Val Glu Met Pro Ile Leu Lys 
            580                 585                 590         


Asp Leu Ala Xaa Val Ala Phe Cys Asp Ala Gln Ser Xaa Gln Glu Ile 
        595                 600                 605             


His Glu Lys Val Leu Asn Glu Ala Val Gly Ala Met Met Tyr His Xaa 
    610                 615                 620                 


Ile Xaa Leu Xaa Arg Glu Asp Leu Glu Lys Phe Lys Ala Leu Arg Val 
625                 630                 635                 640 


Ile Val Arg Ile Gly Ser Gly Tyr Asp Asn Val Asp Ile Lys Ala Ala 
                645                 650                 655     


Gly Glu Leu Gly Ile Ala Val Cys Asn Ile Pro Ser Ala Ala Val Glu 
            660                 665                 670         


Glu Xaa Ala Asp Ser Xaa Ile Cys His Ile Leu Asn Leu Tyr Arg Arg 
        675                 680                 685             


Asn Xaa Trp Leu Tyr Gln Ala Leu Arg Glu Gly Xaa Arg Val Gln Ser 
    690                 695                 700                 


Val Glu Gln Ile Arg Glu Val Ala Ser Gly Ala Ala Arg Ile Arg Gly 
705                 710                 715                 720 


Glu Xaa Leu Gly Leu Ile Gly Phe Gly Arg Xaa Gly Gln Ala Val Ala 
                725                 730                 735     


Val Arg Ala Lys Ala Phe Gly Phe Ser Val Ile Phe Tyr Asp Pro Tyr 
            740                 745                 750         


Leu Gln Asp Gly Ile Glu Arg Ser Leu Gly Val Gln Arg Val Tyr Xaa 
        755                 760                 765             


Leu Gln Asp Leu Leu Tyr Gln Ser Asp Cys Val Ser Leu His Cys Asn 
    770                 775                 780                 


Leu Asn Glu His Asn His His Leu Ile Asn Asp Phe Xaa Ile Lys Gln 
785                 790                 795                 800 


Met Arg Gln Gly Ala Phe Leu Val Asn Ala Ala Arg Gly Gly Leu Val 
                805                 810                 815     


Asp Glu Lys Ala Leu Ala Gln Ala Leu Lys Glu Gly Arg Ile Arg Gly 
            820                 825                 830         


Ala Ala Leu Asp Val His Glu Ser Glu Pro Phe Ser Phe Ala Gln Gly 
        835                 840                 845             


Pro Leu Lys Asp Ala Pro Asn Leu Ile Cys Xaa Pro His Xaa Ala Trp 
    850                 855                 860                 


Tyr Ser Glu Gln Ala Ser Leu Glu Met Arg Glu Ala Ala Ala Xaa Glu 
865                 870                 875                 880 


Ile Arg Arg Ala Ile Xaa Gly Arg Ile Pro Glu Ser Leu Arg Asn Cys 
                885                 890                 895     


Val Asn Lys Glu Phe Phe Val Xaa Ser Ala Pro Trp Ser Val Ile Asp 
            900                 905                 910         


Gln Gln Ala Ile His Pro Glu Leu Asn Gly Ala Xaa Tyr Arg Tyr Pro 
        915                 920                 925             


Pro Gly Ile Val Gly Val Ala Pro Gly Gly Leu Pro Ala Ala Met Glu 
    930                 935                 940                 


Gly Ile Ile Pro Gly Gly Ile Pro Val Xaa His Asn Leu Pro Xaa Val 
945                 950                 955                 960 


Ala His Pro Ser Gln Ala Pro Ser Pro Asn Gln Pro Xaa Lys His Gly 
                965                 970                 975     


Asp Asn Arg Glu His Pro Asn Glu Gln 
            980                 985 


<210> 7161
<211> 513
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<400> 7161
Met Arg Pro Gly Leu Pro Gly Pro Xaa Gly Leu Cys Ala Gln Xaa Ser 
1               5                   10                  15      


Ser Arg Gly Gln Lys Ser Val Leu Lys Gln Lys Glu Ser Cys Gly Ile 
            20                  25                  30          


Trp Gln Leu Tyr His Phe Leu Ser Arg Lys Gln Glu Pro Arg Trp Glu 
        35                  40                  45              


Pro Cys Val Ser Gly Ser Ser Ser Gly Asp Gly Ala Val Ala Asp Leu 
    50                  55                  60                  


Ala Asp Glu Leu Arg Gly Tyr Pro Ala Leu Cys Cys Xaa Leu Pro Val 
65                  70                  75                  80  


His Ser Tyr Arg Ser Trp Ala Gly Ile Arg Pro Gln Ile Met Asn Gly 
                85                  90                  95      


Pro Leu His Pro Arg Pro Leu Val Ala Leu Leu Asp Gly Arg Asp Cys 
            100                 105                 110         


Xaa Val Glu Met Pro Ile Leu Lys Asp Leu Ala Xaa Val Ala Phe Cys 
        115                 120                 125             


Asp Ala Gln Ser Xaa Gln Glu Ile His Glu Lys Val Leu Asn Glu Ala 
    130                 135                 140                 


Val Gly Ala Met Met Tyr His Xaa Ile Xaa Leu Xaa Arg Glu Asp Leu 
145                 150                 155                 160 


Glu Lys Phe Lys Ala Leu Arg Val Ile Val Arg Ile Gly Ser Gly Tyr 
                165                 170                 175     


Asp Asn Val Asp Ile Lys Ala Ala Gly Glu Leu Gly Ile Ala Val Cys 
            180                 185                 190         


Asn Ile Pro Ser Ala Ala Val Glu Glu Xaa Ala Asp Ser Xaa Ile Cys 
        195                 200                 205             


His Ile Leu Asn Leu Tyr Arg Arg Asn Xaa Trp Leu Tyr Gln Ala Leu 
    210                 215                 220                 


Arg Glu Gly Xaa Arg Val Gln Ser Val Glu Gln Ile Arg Glu Val Ala 
225                 230                 235                 240 


Ser Gly Ala Ala Arg Ile Arg Gly Glu Xaa Leu Gly Leu Ile Gly Phe 
                245                 250                 255     


Gly Arg Xaa Gly Gln Ala Val Ala Val Arg Ala Lys Ala Phe Gly Phe 
            260                 265                 270         


Ser Val Ile Phe Tyr Asp Pro Tyr Leu Gln Asp Gly Ile Glu Arg Ser 
        275                 280                 285             


Leu Gly Val Gln Arg Val Tyr Xaa Leu Gln Asp Leu Leu Tyr Gln Ser 
    290                 295                 300                 


Asp Cys Val Ser Leu His Cys Asn Leu Asn Glu His Asn His His Leu 
305                 310                 315                 320 


Ile Asn Asp Phe Xaa Ile Lys Gln Met Arg Gln Gly Ala Phe Leu Val 
                325                 330                 335     


Asn Ala Ala Arg Gly Gly Leu Val Asp Glu Lys Ala Leu Ala Gln Ala 
            340                 345                 350         


Leu Lys Glu Gly Arg Ile Arg Gly Ala Ala Leu Asp Val His Glu Ser 
        355                 360                 365             


Glu Pro Phe Ser Phe Ala Gln Gly Pro Leu Lys Asp Ala Pro Asn Leu 
    370                 375                 380                 


Ile Cys Xaa Pro His Xaa Ala Trp Tyr Ser Glu Gln Ala Ser Leu Glu 
385                 390                 395                 400 


Met Arg Glu Ala Ala Ala Xaa Glu Ile Arg Arg Ala Ile Xaa Gly Arg 
                405                 410                 415     


Ile Pro Glu Ser Leu Arg Asn Cys Val Asn Lys Glu Phe Phe Val Xaa 
            420                 425                 430         


Ser Ala Pro Trp Ser Val Ile Asp Gln Gln Ala Ile His Pro Glu Leu 
        435                 440                 445             


Asn Gly Ala Xaa Tyr Arg Tyr Pro Pro Gly Ile Val Gly Val Ala Pro 
    450                 455                 460                 


Gly Gly Leu Pro Ala Ala Met Glu Gly Ile Ile Pro Gly Gly Ile Pro 
465                 470                 475                 480 


Val Xaa His Asn Leu Pro Xaa Val Ala His Pro Ser Gln Ala Pro Ser 
                485                 490                 495     


Pro Asn Gln Pro Xaa Lys His Gly Asp Asn Arg Glu His Pro Asn Glu 
            500                 505                 510         


Gln 
    


<210> 7162
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 7162
Xaa Gly Tyr Asp Asn Val Asp Ile Lys Ala Ala Gly Glu Leu Gly Ile 
1               5                   10                  15      


Ala Val Cys Asn Ile Pro Ser Ala Ala Val Glu Glu Xaa Ala Asp Ser 
            20                  25                  30          


Xaa Ile Cys His Ile Leu Asn Leu Tyr Arg Arg Asn Xaa Trp Leu Tyr 
        35                  40                  45              


Gln Ala Leu Arg Glu Gly Xaa Arg Val Gln Ser Val Glu Gln Ile Arg 
    50                  55                  60                  


Glu Val Ala Ser Gly Ala Ala Arg Ile Arg Gly Glu Xaa Leu Gly Leu 
65                  70                  75                  80  


Ile Gly Phe Gly Trp Asp Arg Ala Val Pro Gly Arg Ala Glu Gly Leu 
                85                  90                  95      


His Pro Ala Gly Phe Ala Val Ser Glu Arg Leu Arg Leu Leu Ala Leu 
            100                 105                 110         


Gln Ser Gln Arg Xaa 
        115         


<210> 7163
<211> 399
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<400> 7163
Met Ala Phe Val Xaa Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys 
1               5                   10                  15      


His Xaa His Glu Lys Pro Phe Lys Cys Ser Met Cys Asp Tyr Ala Ser 
            20                  25                  30          


Val Glu Val Ser Lys Leu Lys Arg His Ile Arg Ser His Xaa Gly Glu 
        35                  40                  45              


Arg Pro Phe Gln Cys Ser Leu Cys Ser Tyr Ala Ser Arg Asp Xaa Tyr 
    50                  55                  60                  


Lys Leu Lys Arg His Met Arg Xaa His Ser Gly Glu Lys Pro Tyr Glu 
65                  70                  75                  80  


Cys Tyr Ile Cys His Ala Arg Phe Xaa Gln Ser Gly Xaa Met Lys Met 
                85                  90                  95      


His Ile Leu Gln Lys His Xaa Glu Asn Val Ala Lys Phe His Cys Pro 
            100                 105                 110         


His Cys Asp Xaa Val Ile Ala Arg Lys Ser Asp Leu Gly Val His Leu 
        115                 120                 125             


Arg Lys Gln His Ser Tyr Ile Glu Gln Gly Lys Lys Cys Arg Tyr Cys 
    130                 135                 140                 


Asp Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln Lys Ser 
145                 150                 155                 160 


His Lys Asn Glu Lys Arg Phe Lys Cys Asp Gln Cys Asp Tyr Ala Cys 
                165                 170                 175     


Arg Gln Glu Arg His Met Ile Met His Lys Arg Xaa His Xaa Gly Glu 
            180                 185                 190         


Lys Pro Tyr Ala Cys Ser His Cys Asp Lys Xaa Phe Arg Gln Lys Gln 
        195                 200                 205             


Leu Leu Asp Met His Phe Lys Arg Tyr His Asp Pro Asn Phe Val Pro 
    210                 215                 220                 


Ala Ala Phe Val Cys Ser Lys Cys Gly Lys Xaa Phe Xaa Arg Arg Asn 
225                 230                 235                 240 


Xaa Met Ala Arg His Ala Asp Asn Cys Ala Gly Pro Asp Gly Val Glu 
                245                 250                 255     


Gly Glu Asn Gly Gly Glu Xaa Lys Lys Ser Lys Arg Gly Arg Lys Arg 
            260                 265                 270         


Lys Met Arg Ser Lys Lys Glu Asp Ser Ser Asp Ser Glu Asn Ala Glu 
        275                 280                 285             


Pro Asp Leu Asp Asp Asn Glu Asp Glu Glu Glu Pro Ala Val Glu Ile 
    290                 295                 300                 


Glu Pro Glu Pro Glu Pro Gln Pro Val Xaa Pro Ala Pro Pro Pro Ala 
305                 310                 315                 320 


Lys Lys Arg Arg Gly Arg Pro Pro Gly Arg Xaa Asn Gln Pro Lys Gln 
                325                 330                 335     


Asn Gln Pro Xaa Ala Ile Ile Gln Val Glu Asp Gln Asn Xaa Gly Ala 
            340                 345                 350         


Ile Glu Asn Ile Ile Val Glu Val Lys Lys Glu Pro Asp Ala Glu Pro 
        355                 360                 365             


Ala Glu Gly Glu Glu Glu Glu Ala Gln Pro Ala Ala Xaa Asp Ala Pro 
    370                 375                 380                 


Asn Gly Asp Leu Xaa Pro Glu Met Ile Leu Ser Met Met Asp Arg 
385                 390                 395                 


<210> 7164
<211> 727
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (659)..(659)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<400> 7164
Met Glu Gly Asp Ala Val Glu Ala Ile Val Glu Glu Ser Glu Xaa Phe 
1               5                   10                  15      


Ile Lys Gly Lys Glu Arg Lys Xaa Tyr Gln Arg Arg Arg Glu Gly Gly 
            20                  25                  30          


Gln Glu Glu Asp Ala Cys His Leu Pro Gln Asn Gln Xaa Asp Gly Gly 
        35                  40                  45              


Glu Val Val Gln Asp Val Asn Ser Ser Val Gln Met Val Met Met Glu 
    50                  55                  60                  


Gln Leu Asp Pro Xaa Leu Leu Gln Met Lys Xaa Glu Val Met Glu Gly 
65                  70                  75                  80  


Xaa Val Ala Pro Glu Ala Glu Ala Ala Val Asp Asp Xaa Gln Ile Ile 
                85                  90                  95      


Xaa Leu Gln Val Val Asn Met Glu Glu Gln Pro Ile Asn Ile Gly Glu 
            100                 105                 110         


Leu Gln Leu Val Gln Val Pro Val Pro Val Xaa Val Pro Val Ala Xaa 
        115                 120                 125             


Xaa Ser Val Glu Glu Leu Gln Gly Ala Tyr Glu Asn Glu Val Ser Lys 
    130                 135                 140                 


Glu Gly Leu Ala Glu Ser Glu Pro Met Ile Cys His Xaa Leu Pro Leu 
145                 150                 155                 160 


Pro Glu Gly Phe Gln Val Val Lys Val Gly Ala Asn Gly Glu Val Glu 
                165                 170                 175     


Xaa Leu Glu Gln Gly Glu Leu Pro Pro Gln Glu Asp Pro Ser Trp Gln 
            180                 185                 190         


Lys Asp Pro Asp Tyr Gln Pro Pro Ala Lys Lys Xaa Lys Lys Xaa Lys 
        195                 200                 205             


Lys Ser Lys Leu Arg Tyr Xaa Glu Glu Gly Lys Asp Val Asp Val Ser 
    210                 215                 220                 


Val Tyr Asp Phe Glu Glu Glu Gln Gln Glu Gly Leu Leu Ser Glu Val 
225                 230                 235                 240 


Asn Ala Glu Lys Val Val Gly Asn Met Lys Pro Pro Lys Pro Xaa Lys 
                245                 250                 255     


Ile Lys Lys Lys Gly Val Lys Lys Xaa Phe Gln Cys Glu Leu Cys Ser 
            260                 265                 270         


Tyr Xaa Cys Pro Arg Arg Ser Asn Leu Asp Arg His Met Lys Ser His 
        275                 280                 285             


Xaa Asp Glu Arg Pro His Lys Cys His Leu Cys Gly Arg Ala Phe Arg 
    290                 295                 300                 


Xaa Val Xaa Leu Leu Arg Asn His Leu Asn Xaa His Xaa Gly Xaa Arg 
305                 310                 315                 320 


Pro His Lys Cys Pro Asp Cys Asp Met Ala Phe Val Xaa Ser Gly Glu 
                325                 330                 335     


Leu Val Arg His Arg Arg Tyr Lys His Xaa His Glu Lys Pro Phe Lys 
            340                 345                 350         


Cys Ser Met Cys Asp Tyr Ala Ser Val Glu Val Ser Lys Leu Lys Arg 
        355                 360                 365             


His Ile Arg Ser His Xaa Gly Glu Arg Pro Phe Gln Cys Ser Leu Cys 
    370                 375                 380                 


Ser Tyr Ala Ser Arg Asp Xaa Tyr Lys Leu Lys Arg His Met Arg Xaa 
385                 390                 395                 400 


His Ser Gly Glu Lys Pro Tyr Glu Cys Tyr Ile Cys His Ala Arg Phe 
                405                 410                 415     


Xaa Gln Ser Gly Xaa Met Lys Met His Ile Leu Gln Lys His Xaa Glu 
            420                 425                 430         


Asn Val Ala Lys Phe His Cys Pro His Cys Asp Xaa Val Ile Ala Arg 
        435                 440                 445             


Lys Ser Asp Leu Gly Val His Leu Arg Lys Gln His Ser Tyr Ile Glu 
    450                 455                 460                 


Gln Gly Lys Lys Cys Arg Tyr Cys Asp Ala Val Phe His Glu Arg Tyr 
465                 470                 475                 480 


Ala Leu Ile Gln His Gln Lys Ser His Lys Asn Glu Lys Arg Phe Lys 
                485                 490                 495     


Cys Asp Gln Cys Asp Tyr Ala Cys Arg Gln Glu Arg His Met Ile Met 
            500                 505                 510         


His Lys Arg Xaa His Xaa Gly Glu Lys Pro Tyr Ala Cys Ser His Cys 
        515                 520                 525             


Asp Lys Xaa Phe Arg Gln Lys Gln Leu Leu Asp Met His Phe Lys Arg 
    530                 535                 540                 


Tyr His Asp Pro Asn Phe Val Pro Ala Ala Phe Val Cys Ser Lys Cys 
545                 550                 555                 560 


Gly Lys Xaa Phe Xaa Arg Arg Asn Xaa Met Ala Arg His Ala Asp Asn 
                565                 570                 575     


Cys Ala Gly Pro Asp Gly Val Glu Gly Glu Asn Gly Gly Glu Xaa Lys 
            580                 585                 590         


Lys Ser Lys Arg Gly Arg Lys Arg Lys Met Arg Ser Lys Lys Glu Asp 
        595                 600                 605             


Ser Ser Asp Ser Glu Asn Ala Glu Pro Asp Leu Asp Asp Asn Glu Asp 
    610                 615                 620                 


Glu Glu Glu Pro Ala Val Glu Ile Glu Pro Glu Pro Glu Pro Gln Pro 
625                 630                 635                 640 


Val Xaa Pro Ala Pro Pro Pro Ala Lys Lys Arg Arg Gly Arg Pro Pro 
                645                 650                 655     


Gly Arg Xaa Asn Gln Pro Lys Gln Asn Gln Pro Xaa Ala Ile Ile Gln 
            660                 665                 670         


Val Glu Asp Gln Asn Xaa Gly Ala Ile Glu Asn Ile Ile Val Glu Val 
        675                 680                 685             


Lys Lys Glu Pro Asp Ala Glu Pro Ala Glu Gly Glu Glu Glu Glu Ala 
    690                 695                 700                 


Gln Pro Ala Ala Xaa Asp Ala Pro Asn Gly Asp Leu Xaa Pro Glu Met 
705                 710                 715                 720 


Ile Leu Ser Met Met Asp Arg 
                725         


<210> 7165
<211> 404
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<400> 7165
Met Ala Ala Xaa Glu Ile Ser Val Leu Ser Glu Gln Phe Xaa Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Xaa Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Xaa Leu Gln Xaa Val His Phe Xaa Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Xaa 
                165                 170                 175     


Xaa Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Xaa Lys Glu Gln Leu Phe Phe Val Glu Xaa Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Xaa Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Xaa Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Xaa Lys Asn Gln Arg Lys Xaa Lys Gly Ala Lys Gly Xaa 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Xaa Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Xaa His Xaa Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Xaa Phe Arg Xaa Val Xaa Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Xaa His Xaa Gly Xaa Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Xaa Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Xaa His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Val Lys Pro Phe Leu Asp Leu Lys Leu His Gly Ile Leu Val Glu 
        355                 360                 365             


Ala Ala Val Gln Val Xaa Pro Ser Val Xaa Asn Ser Arg Ile Cys Tyr 
    370                 375                 380                 


Lys Gln Ala Phe Tyr Tyr Ser Tyr Lys Ile Tyr Ala Gly Asn Asn Met 
385                 390                 395                 400 


His Ser Leu Leu 
                


<210> 7166
<211> 426
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<400> 7166
Met Ala Ala Xaa Glu Ile Ser Val Leu Ser Glu Gln Phe Xaa Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Xaa Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Xaa Leu Gln Xaa Val His Phe Xaa Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Xaa 
                165                 170                 175     


Xaa Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Xaa Lys Glu Gln Leu Phe Phe Val Glu Xaa Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Xaa Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Xaa Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Xaa Lys Asn Gln Arg Lys Xaa Lys Gly Ala Lys Gly Xaa 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Xaa Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Xaa His Xaa Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Xaa Phe Arg Xaa Val Xaa Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Xaa His Xaa Gly Xaa Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Xaa Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Xaa His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Xaa Gly Glu Arg 
        355                 360                 365             


Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp Xaa Tyr Lys 
    370                 375                 380                 


Leu Lys Arg His Met Arg Xaa His Ser Gly Lys Gly Ser Gly Ala Glu 
385                 390                 395                 400 


Gly Leu Ile Pro Xaa Val Leu Xaa Leu Lys Ala Ser Phe Lys Lys Leu 
                405                 410                 415     


Leu Phe Ile Gly Xaa Ile Lys Val Gln Arg 
            420                 425     


<210> 7167
<211> 427
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<400> 7167
Met Ala Ala Xaa Glu Ile Ser Val Leu Ser Glu Gln Phe Xaa Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Xaa Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Xaa Leu Gln Xaa Val His Phe Xaa Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Xaa 
                165                 170                 175     


Xaa Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Xaa Lys Glu Gln Leu Phe Phe Val Glu Xaa Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Xaa Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Xaa Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Xaa Lys Asn Gln Arg Lys Xaa Lys Gly Ala Lys Gly Xaa 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Xaa Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Xaa His Xaa Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Xaa Phe Arg Xaa Val Xaa Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Xaa His Xaa Gly Xaa Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Xaa Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Xaa His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Xaa Gly Glu Arg 
        355                 360                 365             


Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp Xaa Tyr Lys 
    370                 375                 380                 


Leu Lys Arg His Met Arg Xaa His Ser Glu Ala Xaa Ser Lys Arg Ser 
385                 390                 395                 400 


Leu Gln Glu Ile Pro Arg Cys Lys Phe His Pro Asp Cys Leu Gln Met 
                405                 410                 415     


Leu Gln Val Trp Gln Arg Leu Phe Pro Leu Asp 
            420                 425         


<210> 7168
<211> 451
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<400> 7168
Met Ala Ala Xaa Glu Ile Ser Val Leu Ser Glu Gln Phe Xaa Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Xaa Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Xaa Leu Gln Xaa Val His Phe Xaa Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Xaa 
                165                 170                 175     


Xaa Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Xaa Lys Glu Gln Leu Phe Phe Val Glu Xaa Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Xaa Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Xaa Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Xaa Lys Asn Gln Arg Lys Xaa Lys Gly Ala Lys Gly Xaa 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Xaa Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Xaa His Xaa Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Xaa Phe Arg Xaa Val Xaa Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Xaa His Xaa Gly Xaa Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Xaa Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Xaa His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Xaa Gly Glu Arg 
        355                 360                 365             


Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp Xaa Tyr Lys 
    370                 375                 380                 


Leu Lys Arg His Met Arg Xaa His Ser Gly Glu Lys Pro Tyr Glu Cys 
385                 390                 395                 400 


His Ile Cys His Xaa Arg Phe Xaa Gln Ser Gly Xaa Met Lys Ile His 
                405                 410                 415     


Ile Leu Gln Lys His Gly Glu Asn Val Pro Lys Tyr Gln Cys Pro His 
            420                 425                 430         


Cys Ala Xaa Ile Ile Ala Arg Lys Ser Asp Leu Arg Phe Leu Gly Leu 
        435                 440                 445             


Pro Phe Pro 
    450     


<210> 7169
<211> 483
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<400> 7169
Met Ala Ala Xaa Glu Ile Ser Val Leu Ser Glu Gln Phe Xaa Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Xaa Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Xaa Leu Gln Xaa Val His Phe Xaa Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Xaa 
                165                 170                 175     


Xaa Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Xaa Lys Glu Gln Leu Phe Phe Val Glu Xaa Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Xaa Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Xaa Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Xaa Lys Asn Gln Arg Lys Xaa Lys Gly Ala Lys Gly Xaa 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Xaa Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Xaa His Xaa Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Xaa Phe Arg Xaa Val Xaa Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Xaa His Xaa Gly Xaa Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Xaa Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Xaa His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Glu Arg His Met Xaa Ala His Ile Arg Xaa His Xaa Gly Glu Lys 
        355                 360                 365             


Pro Phe Xaa Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu 
    370                 375                 380                 


Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe Ile Pro Xaa 
385                 390                 395                 400 


Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg Trp Ile Leu 
                405                 410                 415     


Trp Val Gly Asn Ser Glu Val Ala Glu Leu Gly Gly Pro Gly Ser Gly 
            420                 425                 430         


Pro Leu Leu Arg Leu Gln Ser Gly Cys Pro Pro Gly Leu His His Pro 
        435                 440                 445             


Lys Ala Gly Leu Gly Pro Glu Asp Pro Leu Pro Gly Gln Leu Arg His 
    450                 455                 460                 


Xaa Xaa Ala Gly Xaa Gly Leu Ser Ser Leu Leu Gln Gly Pro Leu Cys 
465                 470                 475                 480 


Arg Ala Ala 
            


<210> 7170
<211> 573
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<400> 7170
Met Ala Ala Xaa Glu Ile Ser Val Leu Ser Glu Gln Phe Xaa Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Xaa Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Xaa Leu Gln Xaa Val His Phe Xaa Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Xaa 
                165                 170                 175     


Xaa Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Xaa Lys Glu Gln Leu Phe Phe Val Glu Xaa Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Xaa Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Xaa Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Xaa Lys Asn Gln Arg Lys Xaa Lys Gly Ala Lys Gly Xaa 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Xaa Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Xaa His Xaa Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Xaa Phe Arg Xaa Val Xaa Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Xaa His Xaa Gly Xaa Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Xaa Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Xaa His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Xaa Gly Glu Arg 
        355                 360                 365             


Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp Xaa Tyr Lys 
    370                 375                 380                 


Leu Lys Arg His Met Arg Xaa His Ser Gly Glu Lys Pro Tyr Glu Cys 
385                 390                 395                 400 


His Ile Cys His Xaa Arg Phe Xaa Gln Ser Gly Xaa Met Lys Ile His 
                405                 410                 415     


Ile Leu Gln Lys His Gly Glu Asn Val Pro Lys Tyr Gln Cys Pro His 
            420                 425                 430         


Cys Ala Xaa Ile Ile Ala Arg Lys Ser Asp Leu Arg Val His Met Arg 
        435                 440                 445             


Asn Leu His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser 
    450                 455                 460                 


Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln Lys Xaa His 
465                 470                 475                 480 


Lys Asn Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr Ala Cys Lys 
                485                 490                 495     


Gln Glu Arg His Met Xaa Ala His Ile Arg Xaa His Xaa Gly Glu Lys 
            500                 505                 510         


Pro Phe Xaa Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu 
        515                 520                 525             


Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe Ile Pro Xaa 
    530                 535                 540                 


Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg Trp Ile Xaa 
545                 550                 555                 560 


Ser Lys Trp Ser Gly Leu Lys Pro Gln Xaa Phe Ile Xaa 
                565                 570             


<210> 7171
<211> 613
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(591)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<400> 7171
Met Ala Ala Xaa Glu Ile Ser Val Leu Ser Glu Gln Phe Xaa Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Xaa Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Xaa Leu Gln Xaa Val His Phe Xaa Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Xaa 
                165                 170                 175     


Xaa Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Xaa Lys Glu Gln Leu Phe Phe Val Glu Xaa Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Xaa Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Xaa Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Xaa Lys Asn Gln Arg Lys Xaa Lys Gly Ala Lys Gly Xaa 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Xaa Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Xaa His Xaa Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Xaa Phe Arg Xaa Val Xaa Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Xaa His Xaa Gly Xaa Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Xaa Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Xaa His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Xaa Gly Glu Arg 
        355                 360                 365             


Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp Xaa Tyr Lys 
    370                 375                 380                 


Leu Lys Arg His Met Arg Xaa His Ser Gly Val His Met Arg Asn Leu 
385                 390                 395                 400 


His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser Ala Val 
                405                 410                 415     


Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln Lys Xaa His Lys Asn 
            420                 425                 430         


Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr Ala Cys Lys Gln Glu 
        435                 440                 445             


Arg His Met Xaa Ala His Ile Arg Xaa His Xaa Gly Glu Lys Pro Phe 
    450                 455                 460                 


Xaa Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu Leu Asn 
465                 470                 475                 480 


Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe Ile Pro Xaa Val Tyr 
                485                 490                 495     


Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg Trp Ile Asn Leu His 
            500                 505                 510         


Arg His Ser Glu Lys Cys Gly Ser Gly Glu Ala Lys Ser Ala Ala Ser 
        515                 520                 525             


Gly Lys Gly Arg Arg Xaa Arg Lys Arg Lys Gln Xaa Ile Leu Lys Glu 
    530                 535                 540                 


Ala Xaa Lys Gly Gln Lys Glu Ala Ala Lys Gly Trp Lys Glu Ala Ala 
545                 550                 555                 560 


Asn Gly Asp Glu Ala Ala Ala Glu Glu Ala Ser Xaa Xaa Lys Gly Glu 
                565                 570                 575     


Gln Phe Pro Gly Glu Met Phe Pro Val Ala Cys Arg Glu Xaa Xaa Ala 
            580                 585                 590         


Arg Val Lys Glu Glu Val Asp Glu Gly Val Xaa Cys Glu Met Leu Leu 
        595                 600                 605             


Asn Xaa Met Asp Lys 
    610             


<210> 7172
<211> 627
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<400> 7172
Met Ala Ala Xaa Glu Ile Ser Val Leu Ser Glu Gln Phe Xaa Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Xaa Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Xaa Leu Gln Xaa Val His Phe Xaa Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Xaa 
                165                 170                 175     


Xaa Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Xaa Lys Glu Gln Leu Phe Phe Val Glu Xaa Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Xaa Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Xaa Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Xaa Lys Asn Gln Arg Lys Xaa Lys Gly Ala Lys Gly Xaa 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Xaa Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Xaa His Xaa Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Xaa Phe Arg Xaa Val Xaa Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Xaa His Xaa Gly Xaa Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Xaa Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Xaa His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Xaa Gly Glu Arg 
        355                 360                 365             


Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp Xaa Tyr Lys 
    370                 375                 380                 


Leu Lys Arg His Met Arg Xaa His Ser Gly Glu Lys Pro Tyr Glu Cys 
385                 390                 395                 400 


His Ile Cys His Xaa Arg Phe Xaa Gln Ser Gly Xaa Met Lys Ile His 
                405                 410                 415     


Ile Leu Gln Lys His Gly Glu Asn Val Pro Lys Tyr Gln Cys Pro His 
            420                 425                 430         


Cys Ala Xaa Ile Ile Ala Arg Lys Ser Asp Leu Arg Val His Met Arg 
        435                 440                 445             


Asn Leu His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser 
    450                 455                 460                 


Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln Lys Xaa His 
465                 470                 475                 480 


Lys Asn Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr Ala Cys Lys 
                485                 490                 495     


Gln Glu Arg His Met Xaa Ala His Ile Arg Xaa His Xaa Gly Glu Lys 
            500                 505                 510         


Pro Phe Xaa Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu 
        515                 520                 525             


Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe Ile Pro Xaa 
    530                 535                 540                 


Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg Trp Ile Leu 
545                 550                 555                 560 


Trp Val Gly Asn Ser Glu Val Ala Glu Leu Gly Gly Pro Gly Ser Gly 
                565                 570                 575     


Pro Leu Leu Arg Leu Gln Ser Gly Cys Pro Pro Gly Leu His His Pro 
            580                 585                 590         


Lys Ala Gly Leu Gly Pro Glu Asp Pro Leu Pro Gly Gln Leu Arg His 
        595                 600                 605             


Xaa Xaa Ala Gly Xaa Gly Leu Ser Ser Leu Leu Gln Gly Pro Leu Cys 
    610                 615                 620                 


Arg Ala Ala 
625         


<210> 7173
<211> 663
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<400> 7173
Met Ala Ala Xaa Glu Ile Ser Val Leu Ser Glu Gln Phe Xaa Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Xaa Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Xaa Leu Gln Xaa Val His Phe Xaa Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Xaa 
                165                 170                 175     


Xaa Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Xaa Lys Glu Gln Leu Phe Phe Val Glu Xaa Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Xaa Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Xaa Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Xaa Lys Asn Gln Arg Lys Xaa Lys Gly Ala Lys Gly Xaa 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Xaa Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Xaa His Xaa Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Xaa Phe Arg Xaa Val Xaa Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Xaa His Xaa Gly Xaa Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Xaa Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Xaa His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Xaa Gly Glu Arg 
        355                 360                 365             


Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp Xaa Tyr Lys 
    370                 375                 380                 


Leu Lys Arg His Met Arg Xaa His Ser Gly Glu Lys Pro Tyr Glu Cys 
385                 390                 395                 400 


His Ile Cys His Xaa Arg Phe Xaa Gln Ser Gly Xaa Met Lys Ile His 
                405                 410                 415     


Ile Leu Gln Lys His Gly Glu Asn Val Pro Lys Tyr Gln Cys Pro His 
            420                 425                 430         


Cys Ala Xaa Ile Ile Ala Arg Lys Ser Asp Leu Arg Val His Met Arg 
        435                 440                 445             


Asn Leu His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser 
    450                 455                 460                 


Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln Lys Xaa His 
465                 470                 475                 480 


Lys Asn Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr Ala Cys Lys 
                485                 490                 495     


Gln Glu Arg His Met Xaa Ala His Ile Arg Xaa His Xaa Gly Glu Lys 
            500                 505                 510         


Pro Phe Xaa Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu 
        515                 520                 525             


Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe Ile Pro Xaa 
    530                 535                 540                 


Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg Trp Ile Asn 
545                 550                 555                 560 


Leu His Arg His Ser Glu Lys Cys Gly Ser Gly Glu Ala Lys Ser Ala 
                565                 570                 575     


Ala Ser Gly Lys Gly Arg Arg Xaa Arg Lys Arg Lys Gln Xaa Ile Leu 
            580                 585                 590         


Lys Glu Ala Xaa Lys Gly Gln Lys Glu Ala Ala Lys Gly Trp Lys Glu 
        595                 600                 605             


Ala Ala Asn Gly Asp Glu Ala Ala Ala Glu Glu Ala Ser Xaa Xaa Lys 
    610                 615                 620                 


Gly Glu Gln Phe Pro Gly Glu Met Phe Pro Val Ala Cys Arg Glu Xaa 
625                 630                 635                 640 


Xaa Ala Arg Val Lys Glu Glu Val Asp Glu Gly Val Xaa Cys Glu Met 
                645                 650                 655     


Leu Leu Asn Xaa Met Asp Lys 
            660             


<210> 7174
<211> 665
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<400> 7174
Met Ala Ala Xaa Glu Ile Ser Val Leu Ser Glu Gln Phe Xaa Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Xaa Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Xaa Leu Gln Xaa Val His Phe Xaa Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Xaa 
                165                 170                 175     


Xaa Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Xaa Lys Glu Gln Leu Phe Phe Val Glu Xaa Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Xaa Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Xaa Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Xaa Lys Asn Gln Arg Lys Xaa Lys Gly Ala Lys Gly Xaa 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Xaa Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Xaa His Xaa Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Xaa Phe Arg Xaa Val Xaa Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Xaa His Xaa Gly Xaa Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Xaa Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Xaa His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Xaa Gly Glu Arg 
        355                 360                 365             


Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp Xaa Tyr Lys 
    370                 375                 380                 


Leu Lys Arg His Met Arg Xaa His Ser Gly Glu Lys Pro Tyr Glu Cys 
385                 390                 395                 400 


His Ile Cys His Xaa Arg Phe Xaa Gln Ser Gly Xaa Met Lys Ile His 
                405                 410                 415     


Ile Leu Gln Lys His Gly Glu Asn Val Pro Lys Tyr Gln Cys Pro His 
            420                 425                 430         


Cys Ala Xaa Ile Ile Ala Arg Lys Ser Asp Leu Arg Val His Met Arg 
        435                 440                 445             


Asn Leu His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser 
    450                 455                 460                 


Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln Lys Xaa His 
465                 470                 475                 480 


Lys Asn Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr Ala Cys Lys 
                485                 490                 495     


Gln Glu Arg His Met Xaa Ala His Ile Arg Xaa His Xaa Gly Glu Lys 
            500                 505                 510         


Pro Phe Xaa Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu 
        515                 520                 525             


Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe Ile Pro Xaa 
    530                 535                 540                 


Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg Trp Ile Asn 
545                 550                 555                 560 


Leu His Arg His Ser Glu Lys Cys Gly Ser Gly Glu Ala Lys Ser Ala 
                565                 570                 575     


Ala Ser Gly Lys Gly Arg Arg Xaa Arg Lys Arg Lys Gln Xaa Ile Leu 
            580                 585                 590         


Lys Glu Ala Xaa Lys Gly Gln Lys Glu Ala Ala Lys Gly Trp Lys Glu 
        595                 600                 605             


Ala Ala Asn Gly Asp Gly Val Ile Ser Ala His Arg Asn Leu Cys Leu 
    610                 615                 620                 


Leu Gly Ser Ser Asp Ser His Ala Ser Val Ser Gly Ala Gly Ile Xaa 
625                 630                 635                 640 


Asp Ala Arg His His Ala Trp Leu Ile Val Leu Leu Phe Leu Val Glu 
                645                 650                 655     


Met Gly Phe Tyr His Val Ser His Ser 
            660                 665 


<210> 7175
<211> 700
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<400> 7175
Met Ala Ala Xaa Glu Ile Ser Val Leu Ser Glu Gln Phe Xaa Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Xaa Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Xaa Leu Gln Xaa Val His Phe Xaa Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Xaa 
                165                 170                 175     


Xaa Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Xaa Lys Glu Gln Leu Phe Phe Val Glu Xaa Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Xaa Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Xaa Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Xaa Lys Asn Gln Arg Lys Xaa Lys Gly Ala Lys Gly Xaa 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Xaa Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Xaa His Xaa Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Xaa Phe Arg Xaa Val Xaa Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Xaa His Xaa Gly Xaa Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Xaa Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Xaa His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Xaa Gly Glu Arg 
        355                 360                 365             


Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp Xaa Tyr Lys 
    370                 375                 380                 


Leu Lys Arg His Met Arg Xaa His Ser Gly Glu Lys Pro Tyr Glu Cys 
385                 390                 395                 400 


His Ile Cys His Xaa Arg Phe Xaa Gln Ser Gly Xaa Met Lys Ile His 
                405                 410                 415     


Ile Leu Gln Lys His Gly Glu Asn Val Pro Lys Tyr Gln Cys Pro His 
            420                 425                 430         


Cys Ala Xaa Ile Ile Ala Arg Lys Ser Asp Leu Arg Val His Met Arg 
        435                 440                 445             


Asn Leu His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser 
    450                 455                 460                 


Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln Lys Xaa His 
465                 470                 475                 480 


Lys Asn Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr Ala Cys Lys 
                485                 490                 495     


Gln Glu Arg His Met Xaa Ala His Ile Arg Xaa His Xaa Gly Glu Lys 
            500                 505                 510         


Pro Phe Xaa Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu 
        515                 520                 525             


Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe Ile Pro Xaa 
    530                 535                 540                 


Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg Trp Ile Asn 
545                 550                 555                 560 


Leu His Arg His Ser Glu Lys Cys Gly Ser Gly Glu Ala Lys Ser Ala 
                565                 570                 575     


Ala Ser Gly Lys Gly Arg Arg Xaa Arg Lys Arg Lys Gln Xaa Ile Leu 
            580                 585                 590         


Lys Glu Ala Xaa Lys Gly Gln Lys Glu Ala Ala Lys Gly Trp Lys Glu 
        595                 600                 605             


Ala Ala Asn Gly Asp Glu Ala Ala Ala Glu Glu Ala Ser Xaa Xaa Lys 
    610                 615                 620                 


Gly Glu Gln Phe Pro Gly Glu Met Phe Pro Val Ala Cys Arg Glu Xaa 
625                 630                 635                 640 


Xaa Ala Arg Val Lys Glu Glu Val Asp Glu Gly Val Xaa Cys Glu Met 
                645                 650                 655     


Leu Leu Asn Xaa Met Asp Asn Ser Ala Gly Cys Xaa Gly Arg Met Met 
            660                 665                 670         


Leu Val Ser Ala Trp Leu Leu Gly Arg Pro Gln Glu Xaa Tyr Asn Gln 
        675                 680                 685             


Gly Arg Arg Arg Arg Gly Ser Arg Arg Val Xaa Trp 
    690                 695                 700 


<210> 7176
<211> 299
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<400> 7176
Met Phe Xaa Ser Ser Arg Met Ser Ser Phe Asn Arg His Met Lys Xaa 
1               5                   10                  15      


His Xaa Ser Glu Lys Pro His Leu Cys His Leu Cys Leu Lys Xaa Phe 
            20                  25                  30          


Arg Xaa Val Xaa Leu Leu Arg Asn His Val Asn Xaa His Xaa Gly Xaa 
        35                  40                  45              


Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met Ala Phe Val Xaa Ser Gly 
    50                  55                  60                  


Glu Leu Val Arg His Arg Arg Tyr Lys His Xaa His Glu Lys Pro Phe 
65                  70                  75                  80  


Lys Cys Ser Met Cys Lys Tyr Ala Ser Val Glu Ala Ser Lys Leu Lys 
                85                  90                  95      


Arg His Val Arg Ser His Xaa Gly Glu Arg Pro Phe Gln Cys Cys Gln 
            100                 105                 110         


Cys Ser Tyr Ala Ser Arg Asp Xaa Tyr Lys Leu Lys Arg His Met Arg 
        115                 120                 125             


Xaa His Ser Gly Glu Lys Pro Tyr Glu Cys His Ile Cys His Xaa Arg 
    130                 135                 140                 


Phe Xaa Gln Ser Gly Xaa Met Lys Ile His Ile Leu Gln Lys His Gly 
145                 150                 155                 160 


Glu Asn Val Pro Lys Tyr Gln Cys Pro His Cys Ala Xaa Ile Ile Ala 
                165                 170                 175     


Arg Lys Ser Asp Leu Arg Val His Met Arg Asn Leu His Ala Tyr Ser 
            180                 185                 190         


Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser Ala Val Phe His Glu Arg 
        195                 200                 205             


Tyr Ala Leu Ile Gln His Gln Lys Xaa His Lys Asn Glu Lys Arg Phe 
    210                 215                 220                 


Lys Cys Lys His Cys Ser Tyr Ala Cys Lys Gln Glu Arg His Met Xaa 
225                 230                 235                 240 


Ala His Ile Arg Xaa His Xaa Gly Glu Lys Pro Phe Xaa Cys Leu Ser 
                245                 250                 255     


Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu Leu Asn Ala His Phe Arg 
            260                 265                 270         


Lys Tyr His Asp Ala Asn Phe Ile Pro Xaa Val Tyr Lys Cys Ser Lys 
        275                 280                 285             


Cys Gly Lys Gly Phe Ser Arg Trp Val Leu Tyr 
    290                 295                 


<210> 7177
<211> 403
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<400> 7177
Met Phe Xaa Ser Ser Arg Met Ser Ser Phe Asn Arg His Met Lys Xaa 
1               5                   10                  15      


His Xaa Ser Glu Lys Pro His Leu Cys His Leu Cys Leu Lys Xaa Phe 
            20                  25                  30          


Arg Xaa Val Xaa Leu Leu Arg Asn His Val Asn Xaa His Xaa Gly Xaa 
        35                  40                  45              


Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met Ala Phe Val Xaa Ser Gly 
    50                  55                  60                  


Glu Leu Val Arg His Arg Arg Tyr Lys His Xaa His Glu Lys Pro Phe 
65                  70                  75                  80  


Lys Cys Ser Met Cys Lys Tyr Ala Ser Val Glu Ala Ser Lys Leu Lys 
                85                  90                  95      


Arg His Val Arg Ser His Xaa Gly Glu Arg Pro Phe Gln Cys Cys Gln 
            100                 105                 110         


Cys Ser Tyr Ala Ser Arg Asp Xaa Tyr Lys Leu Lys Arg His Met Arg 
        115                 120                 125             


Xaa His Ser Gly Glu Lys Pro Tyr Glu Cys His Ile Cys His Xaa Arg 
    130                 135                 140                 


Phe Xaa Gln Ser Gly Xaa Met Lys Ile His Ile Leu Gln Lys His Gly 
145                 150                 155                 160 


Glu Asn Val Pro Lys Tyr Gln Cys Pro His Cys Ala Xaa Ile Ile Ala 
                165                 170                 175     


Arg Lys Ser Asp Leu Arg Val His Met Arg Asn Leu His Ala Tyr Ser 
            180                 185                 190         


Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser Ala Val Phe His Glu Arg 
        195                 200                 205             


Tyr Ala Leu Ile Gln His Gln Lys Xaa His Lys Asn Glu Lys Arg Phe 
    210                 215                 220                 


Lys Cys Lys His Cys Ser Tyr Ala Cys Lys Gln Glu Arg His Met Xaa 
225                 230                 235                 240 


Ala His Ile Arg Xaa His Xaa Gly Glu Lys Pro Phe Xaa Cys Leu Ser 
                245                 250                 255     


Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu Leu Asn Ala His Phe Arg 
            260                 265                 270         


Lys Tyr His Asp Ala Asn Phe Ile Pro Xaa Val Tyr Lys Cys Ser Lys 
        275                 280                 285             


Cys Gly Lys Gly Phe Ser Arg Trp Ile Asn Leu His Arg His Ser Glu 
    290                 295                 300                 


Lys Cys Gly Ser Gly Glu Ala Lys Ser Ala Ala Ser Gly Lys Gly Arg 
305                 310                 315                 320 


Arg Xaa Arg Lys Arg Lys Gln Xaa Ile Leu Lys Glu Ala Xaa Lys Gly 
                325                 330                 335     


Gln Lys Glu Ala Ala Lys Gly Trp Lys Glu Ala Ala Asn Gly Asp Gly 
            340                 345                 350         


Val Ile Ser Ala His Arg Asn Leu Cys Leu Leu Gly Ser Ser Asp Ser 
        355                 360                 365             


His Ala Ser Val Ser Gly Ala Gly Ile Xaa Asp Ala Arg His His Ala 
    370                 375                 380                 


Trp Leu Ile Val Leu Leu Phe Leu Val Glu Met Gly Phe Tyr His Val 
385                 390                 395                 400 


Ser His Ser 
            


<210> 7178
<211> 422
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<400> 7178
Met Ser Gly Asp Glu Arg Ser Asp Glu Ile Val Leu Xaa Val Ser Asn 
1               5                   10                  15      


Ser Asn Val Glu Glu Gln Glu Asp Gln Pro Xaa Ala Gly Gln Ala Asp 
            20                  25                  30          


Ala Glu Lys Ala Lys Ser Xaa Lys Asn Gln Arg Lys Xaa Lys Gly Ala 
        35                  40                  45              


Lys Gly Xaa Phe His Cys Asp Val Cys Met Phe Xaa Ser Ser Arg Met 
    50                  55                  60                  


Ser Ser Phe Asn Arg His Met Lys Xaa His Xaa Ser Glu Lys Pro His 
65                  70                  75                  80  


Leu Cys His Leu Cys Leu Lys Xaa Phe Arg Xaa Val Xaa Leu Leu Arg 
                85                  90                  95      


Asn His Val Asn Xaa His Xaa Gly Xaa Arg Pro Tyr Lys Cys Asn Asp 
            100                 105                 110         


Cys Asn Met Ala Phe Val Xaa Ser Gly Glu Leu Val Arg His Arg Arg 
        115                 120                 125             


Tyr Lys His Xaa His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr 
    130                 135                 140                 


Ala Ser Val Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Xaa 
145                 150                 155                 160 


Gly Glu Arg Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp 
                165                 170                 175     


Xaa Tyr Lys Leu Lys Arg His Met Arg Xaa His Ser Gly Glu Lys Pro 
            180                 185                 190         


Tyr Glu Cys His Ile Cys His Xaa Arg Phe Xaa Gln Ser Gly Xaa Met 
        195                 200                 205             


Lys Ile His Ile Leu Gln Lys His Gly Glu Asn Val Pro Lys Tyr Gln 
    210                 215                 220                 


Cys Pro His Cys Ala Xaa Ile Ile Ala Arg Lys Ser Asp Leu Arg Val 
225                 230                 235                 240 


His Met Arg Asn Leu His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg 
                245                 250                 255     


Tyr Cys Ser Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln 
            260                 265                 270         


Lys Xaa His Lys Asn Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr 
        275                 280                 285             


Ala Cys Lys Gln Glu Arg His Met Xaa Ala His Ile Arg Xaa His Xaa 
    290                 295                 300                 


Gly Glu Lys Pro Phe Xaa Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln 
305                 310                 315                 320 


Lys Gln Leu Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe 
                325                 330                 335     


Ile Pro Xaa Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg 
            340                 345                 350         


Trp Ile Leu Trp Val Gly Asn Ser Glu Val Ala Glu Leu Gly Gly Pro 
        355                 360                 365             


Gly Ser Gly Pro Leu Leu Arg Leu Gln Ser Gly Cys Pro Pro Gly Leu 
    370                 375                 380                 


His His Pro Lys Ala Gly Leu Gly Pro Glu Asp Pro Leu Pro Gly Gln 
385                 390                 395                 400 


Leu Arg His Xaa Xaa Ala Gly Xaa Gly Leu Ser Ser Leu Leu Gln Gly 
                405                 410                 415     


Pro Leu Cys Arg Ala Ala 
            420         


<210> 7179
<211> 460
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<400> 7179
Met Ser Gly Asp Glu Arg Ser Asp Glu Ile Val Leu Xaa Val Ser Asn 
1               5                   10                  15      


Ser Asn Val Glu Glu Gln Glu Asp Gln Pro Xaa Ala Gly Gln Ala Asp 
            20                  25                  30          


Ala Glu Lys Ala Lys Ser Xaa Lys Asn Gln Arg Lys Xaa Lys Gly Ala 
        35                  40                  45              


Lys Gly Xaa Phe His Cys Asp Val Cys Met Phe Xaa Ser Ser Arg Met 
    50                  55                  60                  


Ser Ser Phe Asn Arg His Met Lys Xaa His Xaa Ser Glu Lys Pro His 
65                  70                  75                  80  


Leu Cys His Leu Cys Leu Lys Xaa Phe Arg Xaa Val Xaa Leu Leu Arg 
                85                  90                  95      


Asn His Val Asn Xaa His Xaa Gly Xaa Arg Pro Tyr Lys Cys Asn Asp 
            100                 105                 110         


Cys Asn Met Ala Phe Val Xaa Ser Gly Glu Leu Val Arg His Arg Arg 
        115                 120                 125             


Tyr Lys His Xaa His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr 
    130                 135                 140                 


Ala Ser Val Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Xaa 
145                 150                 155                 160 


Gly Glu Arg Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp 
                165                 170                 175     


Xaa Tyr Lys Leu Lys Arg His Met Arg Xaa His Ser Gly Glu Lys Pro 
            180                 185                 190         


Tyr Glu Cys His Ile Cys His Xaa Arg Phe Xaa Gln Ser Gly Xaa Met 
        195                 200                 205             


Lys Ile His Ile Leu Gln Lys His Gly Glu Asn Val Pro Lys Tyr Gln 
    210                 215                 220                 


Cys Pro His Cys Ala Xaa Ile Ile Ala Arg Lys Ser Asp Leu Arg Val 
225                 230                 235                 240 


His Met Arg Asn Leu His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg 
                245                 250                 255     


Tyr Cys Ser Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln 
            260                 265                 270         


Lys Xaa His Lys Asn Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr 
        275                 280                 285             


Ala Cys Lys Gln Glu Arg His Met Xaa Ala His Ile Arg Xaa His Xaa 
    290                 295                 300                 


Gly Glu Lys Pro Phe Xaa Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln 
305                 310                 315                 320 


Lys Gln Leu Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe 
                325                 330                 335     


Ile Pro Xaa Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg 
            340                 345                 350         


Trp Ile Asn Leu His Arg His Ser Glu Lys Cys Gly Ser Gly Glu Ala 
        355                 360                 365             


Lys Ser Ala Ala Ser Gly Lys Gly Arg Arg Xaa Arg Lys Arg Lys Gln 
    370                 375                 380                 


Xaa Ile Leu Lys Glu Ala Xaa Lys Gly Gln Lys Glu Ala Ala Lys Gly 
385                 390                 395                 400 


Trp Lys Glu Ala Ala Asn Gly Asp Gly Val Ile Ser Ala His Arg Asn 
                405                 410                 415     


Leu Cys Leu Leu Gly Ser Ser Asp Ser His Ala Ser Val Ser Gly Ala 
            420                 425                 430         


Gly Ile Xaa Asp Ala Arg His His Ala Trp Leu Ile Val Leu Leu Phe 
        435                 440                 445             


Leu Val Glu Met Gly Phe Tyr His Val Ser His Ser 
    450                 455                 460 


<210> 7180
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<400> 7180
Met Glu Ile Tyr Gly Ser Ala Val Ala Asp Lys Leu Asp Asn Ser Arg 
1               5                   10                  15      


Ser Ile Leu Lys Arg Arg Tyr Tyr Arg Gln His Cys Xaa Leu Glu Leu 
            20                  25                  30          


Gly Ser Tyr Ile Lys Asp Leu Ser Val Val His Ser Asp Leu Ser Ser 
        35                  40                  45              


Ile Val Ile Leu Asp Asn Ser Pro Gly Ala Tyr Arg Ser His Pro Asp 
    50                  55                  60                  


Asn Ala Ile Pro Ile Lys Ser Trp Phe Ser Asp Pro Ser Asp Xaa Ala 
65                  70                  75                  80  


Leu Leu Asn Leu Leu Pro Met Leu Asp Ala Leu Arg Phe Xaa Ala Asp 
                85                  90                  95      


Val Arg Ser Val Leu Ser Arg Asn Leu His Gln His Arg Leu Trp 
            100                 105                 110     


<210> 7181
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 7181
Met Met Arg Xaa Gln Cys Leu Leu Gly Leu Arg Xaa Phe Val Ala Phe 
1               5                   10                  15      


Ala Ala Lys Leu Trp Ser Phe Phe Ile Tyr Leu Leu Arg Arg Gln Ile 
            20                  25                  30          


Arg Xaa Val Ile Gln Tyr Gln Xaa Val Arg Tyr Asp Ile Leu Pro Leu 
        35                  40                  45              


Ser Pro Val Ser Arg Asn Arg Leu Ala Gln Val Lys Arg Lys Ile Leu 
    50                  55                  60                  


Val Leu Asp Leu Asp Glu Xaa Leu Ile His Ser His His Asp Gly Val 
65                  70                  75                  80  


Leu Arg Pro Xaa Val Arg Pro Gly Xaa Pro Pro Asp Phe Ile Leu Lys 
                85                  90                  95      


Val Val Ile Asp Lys His Pro Val Arg Phe Phe Val His Lys Arg Pro 
            100                 105                 110         


His Val Asp Phe Phe Leu Glu Val Val Ser Gln Trp Tyr 
        115                 120                 125 


<210> 7182
<211> 223
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<400> 7182
Met Met Arg Xaa Gln Cys Leu Leu Gly Leu Arg Xaa Phe Val Ala Phe 
1               5                   10                  15      


Ala Ala Lys Leu Trp Ser Phe Phe Ile Tyr Leu Leu Arg Arg Gln Ile 
            20                  25                  30          


Arg Xaa Val Ile Gln Tyr Gln Xaa Val Arg Tyr Asp Ile Leu Pro Leu 
        35                  40                  45              


Ser Pro Val Ser Arg Asn Arg Leu Ala Gln Val Lys Arg Lys Ile Leu 
    50                  55                  60                  


Val Leu Asp Leu Asp Glu Xaa Leu Ile His Ser His His Asp Gly Val 
65                  70                  75                  80  


Leu Arg Pro Xaa Val Arg Pro Gly Xaa Pro Pro Asp Phe Ile Leu Lys 
                85                  90                  95      


Val Val Ile Asp Lys His Pro Val Arg Phe Phe Val His Lys Arg Pro 
            100                 105                 110         


His Val Asp Phe Phe Leu Glu Val Val Ser Gln Trp Tyr Glu Leu Val 
        115                 120                 125             


Val Phe Xaa Ala Ser Met Glu Ile Tyr Gly Ser Ala Val Ala Asp Lys 
    130                 135                 140                 


Leu Asp Asn Ser Arg Ser Ile Leu Lys Arg Arg Tyr Tyr Arg Gln His 
145                 150                 155                 160 


Cys Xaa Leu Glu Leu Gly Ser Tyr Ile Lys Asp Leu Ser Val Val His 
                165                 170                 175     


Ser Asp Leu Ser Ser Ile Val Ile Leu Asp Asn Ser Pro Gly Ala Tyr 
            180                 185                 190         


Arg Ser His Pro Asp Asn Ala Ile Pro Ile Lys Ser Trp Phe Ser Asp 
        195                 200                 205             


Pro Ser Asp Xaa Ala Leu Leu Asn Leu Leu Pro Met Leu Asp Ala 
    210                 215                 220             


<210> 7183
<211> 244
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<400> 7183
Met Met Arg Xaa Gln Cys Leu Leu Gly Leu Arg Xaa Phe Val Ala Phe 
1               5                   10                  15      


Ala Ala Lys Leu Trp Ser Phe Phe Ile Tyr Leu Leu Arg Arg Gln Ile 
            20                  25                  30          


Arg Xaa Val Ile Gln Tyr Gln Xaa Val Arg Tyr Asp Ile Leu Pro Leu 
        35                  40                  45              


Ser Pro Val Ser Arg Asn Arg Leu Ala Gln Val Lys Arg Lys Ile Leu 
    50                  55                  60                  


Val Leu Asp Leu Asp Glu Xaa Leu Ile His Ser His His Asp Gly Val 
65                  70                  75                  80  


Leu Arg Pro Xaa Val Arg Pro Gly Xaa Pro Pro Asp Phe Ile Leu Lys 
                85                  90                  95      


Val Val Ile Asp Lys His Pro Val Arg Phe Phe Val His Lys Arg Pro 
            100                 105                 110         


His Val Asp Phe Phe Leu Glu Val Val Ser Gln Trp Tyr Glu Leu Val 
        115                 120                 125             


Val Phe Xaa Ala Ser Met Glu Ile Tyr Gly Ser Ala Val Ala Asp Lys 
    130                 135                 140                 


Leu Asp Asn Ser Arg Ser Ile Leu Lys Arg Arg Tyr Tyr Arg Gln His 
145                 150                 155                 160 


Cys Xaa Leu Glu Leu Gly Ser Tyr Ile Lys Asp Leu Ser Val Val His 
                165                 170                 175     


Ser Asp Leu Ser Ser Ile Val Ile Leu Asp Asn Ser Pro Gly Ala Tyr 
            180                 185                 190         


Arg Ser His Pro Asp Asn Ala Ile Pro Ile Lys Ser Trp Phe Ser Asp 
        195                 200                 205             


Pro Ser Asp Xaa Ala Leu Leu Asn Leu Leu Pro Met Leu Asp Ala Leu 
    210                 215                 220                 


Arg Phe Xaa Ala Asp Val Arg Ser Val Leu Ser Arg Asn Leu His Gln 
225                 230                 235                 240 


His Arg Leu Trp 
                


<210> 7184
<211> 67
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<400> 7184
Met Met Arg Xaa Gln Cys Leu Leu Gly Leu Arg Xaa Phe Val Ala Phe 
1               5                   10                  15      


Ala Ala Lys Leu Trp Ser Phe Phe Ile Tyr Leu Leu Arg Arg Gln Ile 
            20                  25                  30          


Arg Xaa Val Ile Gln Tyr Gln Xaa Val Arg Tyr Asp Ile Leu Pro Leu 
        35                  40                  45              


Ser Pro Val Ser Arg Asn Arg Leu Gly Glu Glu Glu Asp Pro Gly Ala 
    50                  55                  60                  


Gly Ser Gly 
65          


<210> 7185
<211> 202
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<400> 7185
Xaa Gln Cys Leu Leu Gly Leu Arg Xaa Phe Val Ala Phe Ala Ala Lys 
1               5                   10                  15      


Leu Trp Ser Phe Phe Ile Tyr Leu Leu Arg Arg Gln Ile Arg Xaa Val 
            20                  25                  30          


Ile Gln Tyr Gln Xaa Val Arg Tyr Asp Ile Leu Pro Leu Ser Pro Val 
        35                  40                  45              


Ser Arg Asn Arg Leu Ala Gln Val Lys Arg Lys Ile Leu Val Leu Asp 
    50                  55                  60                  


Leu Asp Glu Xaa Leu Ile His Ser His His Asp Gly Val Leu Arg Pro 
65                  70                  75                  80  


Xaa Val Arg Pro Gly Xaa Pro Pro Asp Phe Ile Leu Lys Val Ser Gln 
                85                  90                  95      


Trp Tyr Glu Leu Val Val Phe Xaa Ala Ser Met Glu Ile Tyr Gly Ser 
            100                 105                 110         


Ala Val Ala Asp Lys Leu Asp Asn Ser Arg Ser Ile Leu Lys Arg Arg 
        115                 120                 125             


Tyr Tyr Arg Gln His Cys Xaa Leu Glu Leu Gly Ser Tyr Ile Lys Asp 
    130                 135                 140                 


Leu Ser Val Val His Ser Asp Leu Ser Ser Ile Val Ile Leu Asp Asn 
145                 150                 155                 160 


Ser Pro Gly Ala Tyr Arg Ser His Pro Asp Asn Ala Ile Pro Ile Lys 
                165                 170                 175     


Ser Trp Phe Ser Asp Pro Ser Asp Xaa Ala Leu Leu Asn Leu Leu Pro 
            180                 185                 190         


Met Leu Asp Ala Leu Arg Phe Xaa Ala Asp 
        195                 200         


<210> 7186
<211> 208
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<400> 7186
Xaa Gln Tyr Gln Xaa Val Arg Tyr Asp Ile Leu Pro Leu Ser Pro Val 
1               5                   10                  15      


Ser Arg Asn Arg Leu Ala Gln Val Lys Arg Lys Ile Leu Val Leu Asp 
            20                  25                  30          


Leu Asp Glu Xaa Leu Ile His Ser His His Asp Gly Val Leu Arg Pro 
        35                  40                  45              


Xaa Val Arg Pro Gly Xaa Pro Pro Asp Phe Ile Leu Lys Val Val Ile 
    50                  55                  60                  


Asp Lys His Pro Val Arg Phe Phe Val His Lys Arg Pro His Val Asp 
65                  70                  75                  80  


Phe Phe Leu Glu Val Val Ser Gln Trp Tyr Glu Leu Val Val Phe Xaa 
                85                  90                  95      


Ala Ser Met Glu Ile Tyr Gly Ser Ala Val Ala Asp Lys Leu Asp Asn 
            100                 105                 110         


Ser Arg Ser Ile Leu Lys Arg Arg Tyr Tyr Arg Gln His Cys Xaa Leu 
        115                 120                 125             


Glu Leu Gly Ser Tyr Ile Lys Asp Leu Ser Val Val His Ser Asp Leu 
    130                 135                 140                 


Ser Ser Ile Val Ile Leu Asp Asn Ser Pro Gly Ala Tyr Arg Ser His 
145                 150                 155                 160 


Pro Asp Asn Ala Ile Pro Ile Lys Ser Trp Phe Ser Asp Pro Ser Asp 
                165                 170                 175     


Xaa Ala Leu Leu Asn Leu Leu Pro Met Leu Asp Ala Leu Arg Phe Xaa 
            180                 185                 190         


Ala Asp Val Arg Ser Val Leu Ser Arg Asn Leu His Gln His Arg Leu 
        195                 200                 205             


<210> 7187
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 7187
Met Arg Leu Arg Xaa Arg Lys Ala Ser Gln Gln Ser Asn Gln Ile Gln 
1               5                   10                  15      


Xaa Gln Arg Xaa Ala Arg Ala Lys Arg Lys Tyr Ser Glu Val Asp Asp 
            20                  25                  30          


Ser Leu Pro Ser Gly Gly Glu Lys Pro Ser Lys Asn Glu Xaa Gly Leu 
        35                  40                  45              


Leu Ser Ser Ile Lys Lys Phe Ile Lys Gly Ser Xaa Pro Lys Glu Glu 
    50                  55                  60                  


Arg Glu Asn Pro Ser Lys Arg Ser Arg Ile Glu Arg Asp Ile Asp Asn 
65                  70                  75                  80  


Asn Leu Ile Xaa Ser Xaa Pro Arg Ala Gly Glu Lys 
                85                  90          


<210> 7188
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 7188
Met Arg Leu Arg Xaa Arg Lys Ala Ser Gln Gln Ser Asn Gln Ile Gln 
1               5                   10                  15      


Xaa Gln Arg Xaa Ala Arg Ala Lys Arg Lys Tyr Ser Glu Val Asp Asp 
            20                  25                  30          


Ser Leu Pro Ser Gly Gly Glu Lys Pro Ser Lys Asn Glu Xaa Gly Leu 
        35                  40                  45              


Leu Ser Ser Ile Lys Lys Phe Ile Lys Gly Ser Xaa Pro Lys Glu Glu 
    50                  55                  60                  


Arg Glu Asn Pro Ser Lys Arg Ser Arg Ile Glu Arg Asp Ile Asp Asn 
65                  70                  75                  80  


Asn Leu Ile Xaa Ser Xaa Pro Arg Ala Gly Glu Lys Pro Asn Lys Gln 
                85                  90                  95      


Ile Ser Arg Val Arg Arg Lys Ser Gln Val Asn Gly Glu Ala Gly Ser 
            100                 105                 110         


Tyr Glu Met Xaa Asn 
        115         


<210> 7189
<211> 394
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<400> 7189
Met Arg Leu Arg Xaa Arg Lys Ala Ser Gln Gln Ser Asn Gln Ile Gln 
1               5                   10                  15      


Xaa Gln Arg Xaa Ala Arg Ala Lys Arg Lys Tyr Ser Glu Val Asp Asp 
            20                  25                  30          


Ser Leu Pro Ser Gly Gly Glu Lys Pro Ser Lys Asn Glu Xaa Gly Leu 
        35                  40                  45              


Leu Ser Ser Ile Lys Lys Phe Ile Lys Gly Ser Xaa Pro Lys Glu Glu 
    50                  55                  60                  


Arg Glu Asn Pro Ser Lys Arg Ser Arg Ile Glu Arg Asp Ile Asp Asn 
65                  70                  75                  80  


Asn Leu Ile Xaa Ser Xaa Pro Arg Ala Gly Glu Lys Pro Asn Lys Gln 
                85                  90                  95      


Ile Ser Arg Val Arg Arg Lys Ser Gln Val Asn Gly Glu Ala Gly Ser 
            100                 105                 110         


Tyr Glu Met Xaa Asn Gln His Val Lys Gln Asn Gly Lys Leu Glu Asp 
        115                 120                 125             


Asn Pro Ser Ser Gly Ser Pro Pro Arg Xaa Xaa Leu Leu Gly Xaa Ile 
    130                 135                 140                 


Phe Ser Pro Val Phe Asn Phe Phe Ser Pro Ala Asn Lys Asn Ala Pro 
145                 150                 155                 160 


Val Xaa Pro Asp Ser Gly Tyr Ser Ser Ala His Ala Glu Ala Xaa Tyr 
                165                 170                 175     


Glu Glu Asp Trp Glu Val Phe Asp Pro Tyr Tyr Phe Ile Lys His Val 
            180                 185                 190         


Pro Pro Leu Xaa Glu Glu Gln Leu Asn Arg Lys Pro Ala Leu Pro Leu 
        195                 200                 205             


Lys Xaa Arg Ser Xaa Pro Glu Phe Ser Leu Val Leu Asp Leu Asp Glu 
    210                 215                 220                 


Xaa Leu Val His Cys Ser Leu Asn Glu Leu Glu Asp Ala Ala Leu Xaa 
225                 230                 235                 240 


Phe Pro Val Leu Phe Gln Asp Val Ile Tyr Gln Val Tyr Val Arg Leu 
                245                 250                 255     


Arg Pro Phe Phe Arg Glu Phe Leu Glu Arg Met Ser Gln Met Tyr Glu 
            260                 265                 270         


Ile Ile Leu Phe Xaa Ala Ser Lys Lys Val Tyr Ala Asp Lys Leu Leu 
        275                 280                 285             


Asn Ile Leu Asp Pro Lys Lys Gln Leu Val Arg His Arg Leu Phe Arg 
    290                 295                 300                 


Glu His Cys Val Cys Val Gln Gly Asn Tyr Ile Lys Asp Leu Asn Ile 
305                 310                 315                 320 


Leu Gly Arg Asp Leu Ser Lys Xaa Ile Ile Ile Asp Asn Ser Pro Gln 
                325                 330                 335     


Ala Phe Ala Tyr Gln Leu Ser Asn Gly Ile Pro Ile Glu Ser Trp Phe 
            340                 345                 350         


Met Asp Lys Asn Asp Asn Glu Leu Leu Lys Leu Ile Pro Phe Leu Glu 
        355                 360                 365             


Lys Leu Val Glu Leu Asn Glu Asp Val Arg Pro His Ile Arg Asp Arg 
    370                 375                 380                 


Phe Arg Leu His Asp Leu Leu Pro Pro Asp 
385                 390                 


<210> 7190
<211> 165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<400> 7190
Met Arg Leu Arg Xaa Arg Lys Ala Ser Gln Gln Ser Asn Gln Ile Gln 
1               5                   10                  15      


Xaa Gln Arg Xaa Ala Arg Ala Lys Arg Lys Tyr Ser Glu Val Asp Asp 
            20                  25                  30          


Ser Leu Pro Ser Gly Gly Glu Lys Pro Ser Lys Asn Glu Xaa Gly Leu 
        35                  40                  45              


Leu Ser Ser Ile Lys Lys Phe Ile Lys Gly Ser Xaa Pro Lys Glu Glu 
    50                  55                  60                  


Arg Glu Asn Pro Ser Lys Arg Ser Arg Ile Glu Arg Asp Ile Asp Asn 
65                  70                  75                  80  


Asn Leu Ile Xaa Ser Xaa Pro Arg Ala Gly Glu Lys Pro Asn Lys Gln 
                85                  90                  95      


Ile Ser Arg Val Arg Arg Lys Ser Gln Val Asn Gly Glu Ala Gly Ser 
            100                 105                 110         


Tyr Glu Met Xaa Asn Gln His Val Lys Gln Asn Gly Lys Leu Glu Asp 
        115                 120                 125             


Asn Pro Ser Ser Gly Ser Pro Pro Arg Xaa Xaa Leu Leu Gly Xaa Ile 
    130                 135                 140                 


Phe Ser Pro Val Phe Asn Phe Phe Ser Pro Ala Asn Lys Asn Gly Xaa 
145                 150                 155                 160 


Ser Gly Ser Asp Ser 
                165 


<210> 7191
<211> 466
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<400> 7191
Met Arg Leu Arg Xaa Arg Lys Ala Ser Gln Gln Ser Asn Gln Ile Gln 
1               5                   10                  15      


Xaa Gln Arg Xaa Ala Arg Ala Lys Arg Lys Tyr Ser Glu Val Asp Asp 
            20                  25                  30          


Ser Leu Pro Ser Gly Gly Glu Lys Pro Ser Lys Asn Glu Xaa Gly Leu 
        35                  40                  45              


Leu Ser Ser Ile Lys Lys Phe Ile Lys Gly Ser Xaa Pro Lys Glu Glu 
    50                  55                  60                  


Arg Glu Asn Pro Ser Lys Arg Ser Arg Ile Glu Arg Asp Ile Asp Asn 
65                  70                  75                  80  


Asn Leu Ile Xaa Ser Xaa Pro Arg Ala Gly Glu Lys Pro Asn Lys Gln 
                85                  90                  95      


Ile Ser Arg Val Arg Arg Lys Ser Gln Val Asn Gly Glu Ala Gly Ser 
            100                 105                 110         


Tyr Glu Met Xaa Asn Gln His Val Lys Gln Asn Gly Lys Leu Glu Asp 
        115                 120                 125             


Asn Pro Ser Ser Gly Ser Pro Pro Arg Xaa Xaa Leu Leu Gly Xaa Ile 
    130                 135                 140                 


Phe Ser Pro Val Phe Asn Phe Phe Ser Pro Ala Asn Lys Asn Gly Xaa 
145                 150                 155                 160 


Ser Gly Ser Asp Ser Pro Gly Gln Ala Val Glu Ala Glu Glu Ile Val 
                165                 170                 175     


Lys Gln Leu Asp Met Glu Gln Val Asp Glu Ile Xaa Xaa Ser Xaa Xaa 
            180                 185                 190         


Xaa Ser Xaa Asn Gly Ala Ala Tyr Ser Asn Gln Ala Val Gln Val Arg 
        195                 200                 205             


Pro Ser Leu Asn Asn Gly Leu Glu Glu Ala Glu Glu Xaa Val Asn Arg 
    210                 215                 220                 


Asp Ile Pro Pro Leu Xaa Ala Pro Val Xaa Pro Asp Ser Gly Tyr Ser 
225                 230                 235                 240 


Ser Ala His Ala Glu Ala Xaa Tyr Glu Glu Asp Trp Glu Val Phe Asp 
                245                 250                 255     


Pro Tyr Tyr Phe Ile Lys His Val Pro Pro Leu Xaa Glu Glu Gln Leu 
            260                 265                 270         


Asn Arg Lys Pro Ala Leu Pro Leu Lys Xaa Arg Ser Xaa Pro Glu Phe 
        275                 280                 285             


Ser Leu Val Leu Asp Leu Asp Glu Xaa Leu Val His Cys Ser Leu Asn 
    290                 295                 300                 


Glu Leu Glu Asp Ala Ala Leu Xaa Phe Pro Val Leu Phe Gln Asp Val 
305                 310                 315                 320 


Ile Tyr Gln Val Tyr Val Arg Leu Arg Pro Phe Phe Arg Glu Phe Leu 
                325                 330                 335     


Glu Arg Met Ser Gln Met Tyr Glu Ile Ile Leu Phe Xaa Ala Ser Lys 
            340                 345                 350         


Lys Val Tyr Ala Asp Lys Leu Leu Asn Ile Leu Asp Pro Lys Lys Gln 
        355                 360                 365             


Leu Val Arg His Arg Leu Phe Arg Glu His Cys Val Cys Val Gln Gly 
    370                 375                 380                 


Asn Tyr Ile Lys Asp Leu Asn Ile Leu Gly Arg Asp Leu Ser Lys Xaa 
385                 390                 395                 400 


Ile Ile Ile Asp Asn Ser Pro Gln Ala Phe Ala Tyr Gln Leu Ser Asn 
                405                 410                 415     


Gly Ile Pro Ile Glu Ser Trp Phe Met Asp Lys Asn Asp Asn Glu Leu 
            420                 425                 430         


Leu Lys Leu Ile Pro Phe Leu Glu Lys Leu Val Glu Leu Asn Glu Asp 
        435                 440                 445             


Val Arg Pro His Ile Arg Asp Arg Phe Arg Leu His Asp Leu Leu Pro 
    450                 455                 460                 


Pro Asp 
465     


<210> 7192
<211> 86
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 7192
Xaa Tyr Tyr Phe Ile Lys His Val Pro Pro Leu Xaa Glu Glu Gln Leu 
1               5                   10                  15      


Asn Arg Lys Pro Ala Leu Pro Leu Lys Xaa Arg Ser Xaa Pro Glu Phe 
            20                  25                  30          


Ser Leu Val Leu Asp Leu Asp Glu Xaa Leu Val His Cys Ser Leu Asn 
        35                  40                  45              


Glu Leu Glu Asp Ala Ala Leu Xaa Phe Pro Val Leu Phe Gln Asp Val 
    50                  55                  60                  


Ile Tyr Gln Trp Cys Cys Leu His Leu Leu Ala Lys Lys Lys Tyr Xaa 
65                  70                  75                  80  


Gln Gly Ser Glu Met Ile 
                85      


<210> 7193
<211> 200
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<400> 7193
Met Ser Arg Arg Glu Gly Ser Leu Asp Pro Gln Xaa Asp Ser Ser Val 
1               5                   10                  15      


Ser Leu Leu Pro His Leu Glu Ala Lys Ile Arg Gln Xaa His Ser Leu 
            20                  25                  30          


Ala His Leu Leu Xaa Lys Tyr Ala Glu Gln Leu Leu Gln Glu Tyr Val 
        35                  40                  45              


Gln Leu Gln Gly Asp Pro Phe Gly Leu Pro Ser Phe Ser Pro Pro Arg 
    50                  55                  60                  


Leu Pro Val Ala Gly Leu Ser Ala Pro Ala Pro Ser His Ala Gly Leu 
65                  70                  75                  80  


Pro Val His Glu Arg Leu Arg Leu Asp Ala Ala Ala Leu Ala Ala Leu 
                85                  90                  95      


Pro Pro Leu Leu Asp Ala Val Cys Arg Arg Gln Ala Glu Leu Asn Pro 
            100                 105                 110         


Arg Ala Pro Arg Leu Leu Arg Arg Leu Glu Asp Ala Ala Arg Gln Ala 
        115                 120                 125             


Arg Ala Leu Gly Ala Ala Val Glu Ala Leu Leu Ala Ala Leu Gly Ala 
    130                 135                 140                 


Ala Asn Arg Gly Pro Arg Ala Glu Pro Pro Ala Ala Xaa Ala Ser Ala 
145                 150                 155                 160 


Ala Ser Ala Xaa Gly Val Phe Pro Ala Lys Val Leu Gly Leu Arg Val 
                165                 170                 175     


Cys Gly Leu Tyr Arg Glu Trp Leu Ser Arg Xaa Glu Gly Asp Leu Gly 
            180                 185                 190         


Gln Leu Leu Pro Gly Gly Ser Ala 
        195                 200 


<210> 7194
<211> 201
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<400> 7194
Met Ser Arg Arg Glu Gly Ser Leu Glu Asp Pro Gln Xaa Asp Ser Ser 
1               5                   10                  15      


Val Ser Leu Leu Pro His Leu Glu Ala Lys Ile Arg Gln Xaa His Ser 
            20                  25                  30          


Leu Ala His Leu Leu Xaa Lys Tyr Ala Glu Gln Leu Leu Gln Glu Tyr 
        35                  40                  45              


Val Gln Leu Gln Gly Asp Pro Phe Gly Leu Pro Ser Phe Ser Pro Pro 
    50                  55                  60                  


Arg Leu Pro Val Ala Gly Leu Ser Ala Pro Ala Pro Ser His Ala Gly 
65                  70                  75                  80  


Leu Pro Val His Glu Arg Leu Arg Leu Asp Ala Ala Ala Leu Ala Ala 
                85                  90                  95      


Leu Pro Pro Leu Leu Asp Ala Val Cys Arg Arg Gln Ala Glu Leu Asn 
            100                 105                 110         


Pro Arg Ala Pro Arg Leu Leu Arg Arg Leu Glu Asp Ala Ala Arg Gln 
        115                 120                 125             


Ala Arg Ala Leu Gly Ala Ala Val Glu Ala Leu Leu Ala Ala Leu Gly 
    130                 135                 140                 


Ala Ala Asn Arg Gly Pro Arg Ala Glu Pro Pro Ala Ala Xaa Ala Ser 
145                 150                 155                 160 


Ala Ala Ser Ala Xaa Gly Val Phe Pro Ala Lys Val Leu Gly Leu Arg 
                165                 170                 175     


Val Cys Gly Leu Tyr Arg Glu Trp Leu Ser Arg Xaa Glu Gly Asp Leu 
            180                 185                 190         


Gly Gln Leu Leu Pro Gly Gly Ser Ala 
        195                 200     


<210> 7195
<211> 349
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<400> 7195
Met Xaa Ala Ala Ser Met Gly Pro Val Arg Val Ala Phe Val Val Leu 
1               5                   10                  15      


Leu Ala Leu Cys Ser Arg Pro Ala Val Gly Gln Asn Cys Ser Gly Pro 
            20                  25                  30          


Cys Arg Cys Pro Asp Glu Pro Ala Pro Arg Cys Pro Ala Gly Val Ser 
        35                  40                  45              


Leu Val Leu Asp Gly Cys Gly Cys Cys Arg Val Cys Ala Lys Gln Leu 
    50                  55                  60                  


Gly Glu Leu Cys Xaa Glu Arg Asp Pro Cys Asp Pro His Lys Gly Leu 
65                  70                  75                  80  


Phe Cys His Phe Gly Ser Pro Ala Asn Arg Lys Ile Gly Val Cys Xaa 
                85                  90                  95      


Ala Lys Asp Gly Ala Pro Cys Ile Phe Gly Gly Xaa Val Tyr Arg Ser 
            100                 105                 110         


Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr Gln Cys Xaa Cys Leu Asp 
        115                 120                 125             


Gly Ala Val Gly Cys Met Pro Leu Cys Ser Met Asp Val Arg Leu Pro 
    130                 135                 140                 


Ser Pro Asp Cys Pro Phe Pro Arg Arg Val Lys Leu Pro Gly Lys Cys 
145                 150                 155                 160 


Cys Glu Glu Trp Val Cys Asp Glu Pro Lys Asp Gln Xaa Val Val Gly 
                165                 170                 175     


Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp Xaa Phe Gly Pro Asp Pro 
            180                 185                 190         


Xaa Met Ile Arg Ala Asn Cys Leu Val Gln Xaa Xaa Glu Trp Ser Ala 
        195                 200                 205             


Cys Ser Lys Xaa Cys Gly Met Gly Ile Ser Xaa Arg Val Xaa Asn Asp 
    210                 215                 220                 


Asn Ala Ser Cys Arg Leu Glu Lys Gln Ser Arg Leu Cys Met Val Arg 
225                 230                 235                 240 


Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile Lys Lys Gly Lys Lys Cys 
                245                 250                 255     


Ile Arg Xaa Pro Lys Ile Ser Lys Pro Ile Lys Phe Glu Leu Ser Gly 
            260                 265                 270         


Cys Xaa Ser Met Lys Xaa Tyr Arg Ala Lys Phe Cys Gly Val Cys Xaa 
        275                 280                 285             


Asp Gly Arg Cys Cys Xaa Pro His Arg Xaa Xaa Xaa Leu Pro Val Glu 
    290                 295                 300                 


Phe Lys Cys Pro Asp Gly Glu Val Met Lys Lys Asn Met Met Phe Ile 
305                 310                 315                 320 


Lys Xaa Cys Ala Cys His Tyr Asn Cys Pro Gly Asp Asn Asp Ile Phe 
                325                 330                 335     


Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly Asp Met Ala 
            340                 345                 


<210> 7196
<211> 405
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<400> 7196
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Xaa Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Xaa Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Xaa Xaa Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Glu Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Xaa Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Xaa Val Xaa 
                85                  90                  95      


Ile Xaa His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Xaa Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Xaa Pro Glu Xaa Lys Leu Val Trp Ile Glu Xaa Pro Xaa 
145                 150                 155                 160 


Asn Pro Xaa Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
                165                 170                 175     


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Xaa Phe Met Ser 
            180                 185                 190         


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
        195                 200                 205             


Ser Ala Xaa Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
    210                 215                 220                 


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
225                 230                 235                 240 


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
                245                 250                 255     


Arg Gly Leu Lys Xaa Leu His Val Arg Met Glu Lys His Phe Lys Asn 
            260                 265                 270         


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
        275                 280                 285             


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
    290                 295                 300                 


Arg Gln Cys Xaa Gly Cys Xaa Gly Met Val Xaa Phe Tyr Ile Lys Gly 
305                 310                 315                 320 


Xaa Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Xaa 
                325                 330                 335     


Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
            340                 345                 350         


Ile Met Xaa His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
        355                 360                 365             


Ile Ser Asp Xaa Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
    370                 375                 380                 


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
385                 390                 395                 400 


Ser Gly Ser His Ser 
                405 


<210> 7197
<211> 361
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<400> 7197
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Xaa Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Xaa Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Xaa Xaa Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Glu Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Xaa Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Leu Ala Phe Ala Ser Gly Leu Ala Ala Xaa Val Xaa 
                85                  90                  95      


Ile Xaa His Leu Leu Lys Ala Gly Asp Gln Ile Ile Cys Met Asp Asp 
            100                 105                 110         


Val Tyr Gly Gly Xaa Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
        115                 120                 125             


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
    130                 135                 140                 


Ala Ala Ile Xaa Pro Glu Xaa Lys Arg Pro Leu Ala Leu Gly Ala Asp 
145                 150                 155                 160 


Ile Ser Met Tyr Ser Ala Xaa Lys Tyr Met Asn Gly His Ser Asp Val 
                165                 170                 175     


Val Met Gly Leu Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu 
            180                 185                 190         


Arg Phe Leu Gln Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys 
        195                 200                 205             


Tyr Leu Cys Asn Arg Gly Leu Lys Xaa Leu His Val Arg Met Glu Lys 
    210                 215                 220                 


His Phe Lys Asn Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro 
225                 230                 235                 240 


Trp Val Glu Lys Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His 
                245                 250                 255     


Glu Leu Val Lys Arg Gln Cys Xaa Gly Cys Xaa Gly Met Val Xaa Phe 
            260                 265                 270         


Tyr Ile Lys Gly Xaa Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu 
        275                 280                 285             


Lys Leu Phe Xaa Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Ala 
    290                 295                 300                 


Glu Leu Pro Ala Ile Met Xaa His Ala Ser Val Leu Lys Asn Asp Arg 
305                 310                 315                 320 


Asp Val Leu Gly Ile Ser Asp Xaa Leu Ile Arg Leu Ser Val Gly Leu 
                325                 330                 335     


Glu Asp Glu Glu Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala 
            340                 345                 350         


Ala His Pro Pro Ser Gly Ser His Ser 
        355                 360     


<210> 7198
<211> 373
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<400> 7198
Met Gln Glu Lys Asp Ala Ser Ser Gln Gly Phe Leu Pro His Phe Gln 
1               5                   10                  15      


His Phe Ala Xaa Gln Ala Ile His Val Gly Gln Asp Pro Glu Gln Trp 
            20                  25                  30          


Xaa Ser Arg Ala Val Val Pro Pro Ile Ser Leu Ser Xaa Xaa Phe Lys 
        35                  40                  45              


Gln Gly Ala Pro Gly Gln His Ser Gly Phe Glu Tyr Ser Arg Ser Gly 
    50                  55                  60                  


Asn Pro Xaa Arg Asn Cys Leu Glu Lys Ala Val Ala Ala Leu Asp Gly 
65                  70                  75                  80  


Ala Lys Tyr Cys Xaa Asn Arg Tyr Phe Arg Gln Val Ala Ser Glu Phe 
                85                  90                  95      


Gly Leu Lys Ile Ser Phe Val Asp Cys Ser Lys Ile Lys Leu Leu Glu 
            100                 105                 110         


Ala Ala Ile Xaa Pro Glu Xaa Lys Leu Val Trp Ile Glu Xaa Pro Xaa 
        115                 120                 125             


Asn Pro Xaa Gln Lys Val Ile Asp Ile Glu Gly Cys Ala His Ile Val 
    130                 135                 140                 


His Lys His Gly Asp Ile Ile Leu Val Val Asp Asn Xaa Phe Met Ser 
145                 150                 155                 160 


Pro Tyr Phe Gln Arg Pro Leu Ala Leu Gly Ala Asp Ile Ser Met Tyr 
                165                 170                 175     


Ser Ala Xaa Lys Tyr Met Asn Gly His Ser Asp Val Val Met Gly Leu 
            180                 185                 190         


Val Ser Val Asn Cys Glu Ser Leu His Asn Arg Leu Arg Phe Leu Gln 
        195                 200                 205             


Asn Ser Leu Gly Ala Val Pro Ser Pro Ile Asp Cys Tyr Leu Cys Asn 
    210                 215                 220                 


Arg Gly Leu Lys Xaa Leu His Val Arg Met Glu Lys His Phe Lys Asn 
225                 230                 235                 240 


Gly Met Ala Val Ala Gln Phe Leu Glu Ser Asn Pro Trp Val Glu Lys 
                245                 250                 255     


Val Ile Tyr Pro Gly Leu Pro Ser His Pro Gln His Glu Leu Val Lys 
            260                 265                 270         


Arg Gln Cys Xaa Gly Cys Xaa Gly Met Val Xaa Phe Tyr Ile Lys Gly 
        275                 280                 285             


Xaa Leu Gln His Ala Glu Ile Phe Leu Lys Asn Leu Lys Leu Phe Xaa 
    290                 295                 300                 


Leu Ala Glu Ser Leu Gly Gly Phe Glu Ser Leu Ala Glu Leu Pro Ala 
305                 310                 315                 320 


Ile Met Xaa His Ala Ser Val Leu Lys Asn Asp Arg Asp Val Leu Gly 
                325                 330                 335     


Ile Ser Asp Xaa Leu Ile Arg Leu Ser Val Gly Leu Glu Asp Glu Glu 
            340                 345                 350         


Asp Leu Leu Glu Asp Leu Asp Gln Ala Leu Lys Ala Ala His Pro Pro 
        355                 360                 365             


Ser Gly Ser His Ser 
    370             


<210> 7199
<211> 243
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<400> 7199
Met Arg Pro Gln Gly Pro Ala Ala Ser Pro Gln Arg Leu Arg Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Leu Pro Ala Pro Ser Ser Ala Ser Glu 
            20                  25                  30          


Ile Pro Lys Gly Lys Gln Lys Ala Gln Leu Arg Gln Arg Glu Val Val 
        35                  40                  45              


Asp Leu Tyr Asn Gly Met Cys Leu Gln Gly Pro Ala Gly Val Pro Gly 
    50                  55                  60                  


Arg Asp Gly Ser Pro Gly Ala Asn Gly Ile Pro Gly Xaa Pro Gly Ile 
65                  70                  75                  80  


Pro Gly Arg Asp Gly Phe Lys Gly Glu Lys Gly Glu Cys Leu Arg Glu 
                85                  90                  95      


Ser Phe Glu Glu Ser Trp Xaa Pro Asn Tyr Lys Gln Cys Ser Trp Ser 
            100                 105                 110         


Ser Leu Asn Tyr Gly Ile Asp Leu Gly Lys Ile Ala Glu Cys Xaa Phe 
        115                 120                 125             


Xaa Lys Met Arg Ser Asn Ser Ala Leu Arg Val Leu Phe Ser Gly Ser 
    130                 135                 140                 


Leu Arg Leu Lys Cys Arg Asn Ala Cys Cys Gln Arg Trp Tyr Phe Xaa 
145                 150                 155                 160 


Phe Asn Gly Ala Glu Cys Ser Gly Pro Leu Pro Ile Glu Ala Ile Ile 
                165                 170                 175     


Tyr Leu Asp Gln Gly Ser Pro Glu Met Asn Ser Xaa Ile Asn Ile His 
            180                 185                 190         


Arg Xaa Ser Ser Val Glu Gly Leu Cys Glu Gly Ile Gly Ala Gly Leu 
        195                 200                 205             


Val Asp Val Ala Ile Trp Val Gly Xaa Cys Ser Asp Tyr Pro Lys Gly 
    210                 215                 220                 


Asp Ala Ser Xaa Gly Trp Asn Ser Val Ser Arg Ile Ile Ile Glu Glu 
225                 230                 235                 240 


Leu Pro Lys 
            


<210> 7200
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 7200
Met Arg Pro Gln Gly Pro Ala Ala Ser Pro Gln Arg Leu Arg Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Leu Pro Ala Pro Ser Ser Ala Ser Glu 
            20                  25                  30          


Ile Pro Lys Gly Lys Gln Lys Ala Gln Leu Arg Gln Arg Glu Val Val 
        35                  40                  45              


Asp Leu Tyr Asn Gly Met Cys Leu Gln Gly Pro Ala Gly Val Pro Gly 
    50                  55                  60                  


Arg Asp Gly Ser Pro Gly Ala Asn Gly Ile Pro Gly Xaa Pro Gly Ile 
65                  70                  75                  80  


Pro Gly Arg Asp Gly Phe Lys Gly Glu Lys Gly Glu Cys Leu Arg Glu 
                85                  90                  95      


Ser Phe Glu Glu Ser Trp Xaa Pro Asn Tyr Lys Gln Cys Ser Trp Ser 
            100                 105                 110         


Ser Leu Asn Tyr Gly Ile Asp Leu Gly Lys Ile Ala Val Ser Leu Asn 
        115                 120                 125             


Tyr Phe Lys Ile Glu Ala Arg Phe Lys Gly Phe His Ile Leu Val Leu 
    130                 135                 140                 


Ile Phe Arg 
145         


<210> 7201
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 7201
Met Arg Ser Asn Ser Ala Leu Arg Val Leu Phe Ser Gly Ser Leu Arg 
1               5                   10                  15      


Leu Lys Cys Arg Asn Ala Cys Cys Gln Arg Trp Tyr Phe Xaa Phe Asn 
            20                  25                  30          


Gly Ala Glu Cys Ser Gly Pro Leu Pro Ile Glu Ala Ile Ile Tyr Leu 
        35                  40                  45              


Asp Gln Gly Ser Pro Glu Met Asn Ser Xaa Ile Asn Ile His Arg Xaa 
    50                  55                  60                  


Ser Ser Val Glu Gly Leu Cys Glu Gly Ile Gly Ala Gly Leu Val Asp 
65                  70                  75                  80  


Val Ala Ile Trp Val Gly Xaa Cys Ser Asp Tyr Pro Lys Gly Asp Ala 
                85                  90                  95      


Ser Xaa Gly Trp Asn Ser Val Ser Arg Ile Ile Ile Glu Glu Leu Pro 
            100                 105                 110         


Lys 
    


<210> 7202
<211> 229
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<400> 7202
Met Trp Pro Pro Gly Arg Ser Ile Xaa Val Lys Leu Arg Glu Lys Xaa 
1               5                   10                  15      


Val Ser Arg Lys Leu Glu Met Asn Gly Pro Ser Ala Phe Gln Gly Leu 
            20                  25                  30          


Ile Cys Gly Lys Tyr Asn Gly Met Cys Leu Gln Gly Pro Ala Gly Val 
        35                  40                  45              


Pro Gly Arg Asp Gly Ser Pro Gly Ala Asn Gly Ile Pro Gly Xaa Pro 
    50                  55                  60                  


Gly Ile Pro Gly Arg Asp Gly Phe Lys Gly Glu Lys Gly Glu Cys Leu 
65                  70                  75                  80  


Arg Glu Ser Phe Glu Glu Ser Trp Xaa Pro Asn Tyr Lys Gln Cys Ser 
                85                  90                  95      


Trp Ser Ser Leu Asn Tyr Gly Ile Asp Leu Gly Lys Ile Ala Glu Cys 
            100                 105                 110         


Xaa Phe Xaa Lys Met Arg Ser Asn Ser Ala Leu Arg Val Leu Phe Ser 
        115                 120                 125             


Gly Ser Leu Arg Leu Lys Cys Arg Asn Ala Cys Cys Gln Arg Trp Tyr 
    130                 135                 140                 


Phe Xaa Phe Asn Gly Ala Glu Cys Ser Gly Pro Leu Pro Ile Glu Ala 
145                 150                 155                 160 


Ile Ile Tyr Leu Asp Gln Gly Ser Pro Glu Met Asn Ser Xaa Ile Asn 
                165                 170                 175     


Ile His Arg Xaa Ser Ser Val Glu Gly Leu Cys Glu Gly Ile Gly Ala 
            180                 185                 190         


Gly Leu Val Asp Val Ala Ile Trp Val Gly Xaa Cys Ser Asp Tyr Pro 
        195                 200                 205             


Lys Gly Asp Ala Ser Xaa Gly Trp Asn Ser Val Ser Arg Ile Ile Ile 
    210                 215                 220                 


Glu Glu Leu Pro Lys 
225                 


<210> 7203
<211> 174
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<400> 7203
Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Xaa Arg Xaa Trp Pro Cys Xaa Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Xaa Glu Val Arg Val Xaa Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Xaa Glu Val Cys Ala Ala Xaa Tyr Met Met Gly Asn Glu Leu Xaa 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Xaa Gly Xaa Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Xaa Ile Gln Gly Leu Arg Ala Met Asp Xaa Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Xaa Gln Ile Tyr Val Ile Ala Lys Glu Lys Lys Pro Ser Tyr 
145                 150                 155                 160 


Asn Arg Gly Leu Cys Glu Asn Ala Pro Asn Arg Ala Arg Met 
                165                 170                 


<210> 7204
<211> 223
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<400> 7204
Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Xaa Arg Xaa Trp Pro Cys Xaa Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Xaa Glu Val Arg Val Xaa Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Xaa Glu Val Cys Ala Ala Xaa Tyr Met Met Gly Asn Glu Leu Xaa 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Xaa Gly Xaa Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Xaa Ile Gln Gly Leu Arg Ala Met Asp Xaa Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Xaa Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Xaa Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Xaa Xaa Gly Val Tyr Val Lys Met Pro Pro Xaa Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210> 7205
<211> 79
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<400> 7205
Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Xaa Arg Xaa Trp Pro Cys Xaa Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Ser Lys Glu Lys Lys Pro Ser 
    50                  55                  60                  


Tyr Asn Arg Gly Leu Cys Glu Asn Ala Pro Asn Arg Ala Arg Met 
65                  70                  75                  


<210> 7206
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 7206
Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile 
1               5                   10                  15      


Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Xaa Glu Val 
            20                  25                  30          


Arg Val Xaa Val Leu Arg Gln Ala Asp Ser Gln Val Xaa Glu Val Cys 
        35                  40                  45              


Ala Ala Xaa Tyr Met Met Gly Asn Glu Leu Xaa Phe Leu Asp Asp Ser 
    50                  55                  60                  


Ile Cys Xaa Gly Xaa Ser Ser Gly Asn Gln Val Asn Leu Xaa Ile Gln 
65                  70                  75                  80  


Gly Leu Arg Ala Met Asp Xaa Gly Leu Tyr Ile Cys Lys Val Glu Leu 
                85                  90                  95      


Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Xaa Gln Ile 
            100                 105                 110         


Tyr Val Ile Ala Lys Glu Lys Lys Pro Ser Tyr Asn Arg Gly Leu Cys 
        115                 120                 125             


Glu Asn Ala Pro Asn Arg Ala Arg Met 
    130                 135         


<210> 7207
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 7207
Lys Gln Leu Gln Gln Ala Val Xaa Gly Ile Ser Asn Ala Ala Gln Ala 
1               5                   10                  15      


Xaa Ala Ser Asp Asp Ala Ser Gln His Gln Gly Gly Gly Gly Gly Glu 
            20                  25                  30          


Leu Ala Tyr Ala Leu Asn Asn Phe Asp Lys Gln Ile Ile Val Asp Pro 
        35                  40                  45              


Leu Ser Phe Ser Glu Glu Arg Phe Arg Pro Ser Leu Glu Glu Arg Leu 
    50                  55                  60                  


Glu Ser Ile Ile Ser Gly Ala Ala Leu Met Ala Asp Ser Ser Cys Xaa 
65                  70                  75                  80  


Arg Asp Asp Arg Arg Glu Arg Ile Val Ala Glu Cys Asn Ala Val Arg 
                85                  90                  95      


Gln Ala Leu Gln Asp Leu Leu Ser Glu Tyr Met Gly Asn Gln His Val 
            100                 105                 110         


Ser Ile Pro Ser Ala Val Glu Met Leu Ile Pro Pro Cys Ile Ala His 
        115                 120                 125             


Cys 
    


<210> 7208
<211> 161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<400> 7208
Met Lys Ala Ala Ala Gly Glu Phe Ala Asp Asp Pro Cys Ser Ser Val 
1               5                   10                  15      


Lys Arg Gly Asn Met Val Arg Ala Ala Arg Ala Leu Leu Ser Ala Val 
            20                  25                  30          


Xaa Arg Leu Leu Ile Leu Ala Asp Met Ala Asp Val Tyr Lys Leu Leu 
        35                  40                  45              


Val Gln Leu Lys Val Val Glu Asp Gly Ile Leu Lys Leu Arg Asn Ala 
    50                  55                  60                  


Gly Asn Glu Gln Asp Leu Gly Ile Gln Tyr Lys Ala Leu Lys Pro Glu 
65                  70                  75                  80  


Val Asp Lys Leu Asn Ile Met Ala Ala Lys Arg Gln Gln Glu Leu Lys 
                85                  90                  95      


Asp Val Gly His Arg Asp Gln Met Ala Ala Ala Arg Gly Ile Leu Gln 
            100                 105                 110         


Lys Asn Val Pro Ile Leu Tyr Xaa Ala Ser Gln Ala Cys Leu Gln His 
        115                 120                 125             


Pro Asp Val Ala Ala Tyr Lys Ala Asn Arg Asp Leu Ile Tyr Lys Gln 
    130                 135                 140                 


Leu Gln Gln Ala Val Xaa Gly Ile Ser Asn Ala Ala Gln Ala Xaa Ala 
145                 150                 155                 160 


Ser 
    


<210> 7209
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<400> 7209
Met Xaa Ala Val His Ala Gly Asn Ile Asn Phe Lys Trp Asp Pro Lys 
1               5                   10                  15      


Ser Leu Glu Ile Arg Xaa Leu Ala Val Glu Arg Leu Leu Glu Pro Leu 
            20                  25                  30          


Val Xaa Gln Ile Leu His Leu Ser Ser Glu Gly Lys Pro Lys Lys Gly 
        35                  40                  45              


Gly Val Trp Ile Leu Asp Cys 
    50                  55  


<210> 7210
<211> 37
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<400> 7210
Met Xaa Ala Val His Ala Gly Asn Ile Asn Phe Lys Trp Asp Pro Lys 
1               5                   10                  15      


Ser Leu Glu Ile Arg Xaa Leu Ala Val Glu Arg Leu Leu Glu Pro Leu 
            20                  25                  30          


Val Xaa Gln Val Ile 
        35          


<210> 7211
<211> 94
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<400> 7211
Met Xaa Ala Val His Ala Gly Asn Ile Asn Phe Lys Trp Asp Pro Lys 
1               5                   10                  15      


Ser Leu Glu Ile Arg Xaa Leu Ala Val Glu Arg Leu Leu Glu Pro Leu 
            20                  25                  30          


Val Xaa Gln Val Xaa Xaa Leu Val Asn Xaa Asn Ser Lys Gly Pro Ser 
        35                  40                  45              


Asn Lys Lys Arg Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser 
    50                  55                  60                  


Val Glu Gln Ala Xaa Glu Asn Phe Leu Glu Lys Gly Asp Lys Ile Ala 
65                  70                  75                  80  


Lys Glu Ser Gln Phe Leu Lys Glu Glu Leu Val Ala Ala Val 
                85                  90                  


<210> 7212
<211> 101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<400> 7212
Met Xaa Ala Val His Ala Gly Asn Ile Asn Phe Lys Trp Asp Pro Lys 
1               5                   10                  15      


Ser Leu Glu Ile Arg Xaa Leu Ala Val Glu Arg Leu Leu Glu Pro Leu 
            20                  25                  30          


Val Xaa Gln Val Xaa Xaa Leu Val Asn Xaa Asn Ser Lys Gly Pro Ser 
        35                  40                  45              


Asn Lys Lys Arg Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser 
    50                  55                  60                  


Val Glu Gln Ala Xaa Glu Asn Phe Leu Glu Lys Gly Asp Lys Ile Ala 
65                  70                  75                  80  


Lys Glu Ser Gln Phe Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp 
                85                  90                  95      


Val Arg Lys Gln Gly 
            100     


<210> 7213
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<400> 7213
Met Xaa Ala Val His Ala Gly Asn Ile Asn Phe Lys Trp Asp Pro Lys 
1               5                   10                  15      


Ser Leu Glu Ile Arg Xaa Leu Ala Val Glu Arg Leu Leu Glu Pro Leu 
            20                  25                  30          


Val Xaa Gln Val Xaa Xaa Leu Val Asn Xaa Asn Ser Lys Gly Pro Ser 
        35                  40                  45              


Asn Lys Lys Arg Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser 
    50                  55                  60                  


Val Glu Gln Ala Xaa Glu Asn Phe Leu Glu Lys Gly Asp Lys Ile Ala 
65                  70                  75                  80  


Lys Glu Ser Gln Phe Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp 
                85                  90                  95      


Val Arg Lys Gln Gly Asp Leu Met Lys Ala Ala Ala Gly Glu Phe Ala 
            100                 105                 110         


Asp Asp Pro Cys Ser Ser 
        115             


<210> 7214
<211> 123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<400> 7214
Met Xaa Ala Val His Ala Gly Asn Ile Asn Phe Lys Trp Asp Pro Lys 
1               5                   10                  15      


Ser Leu Glu Ile Arg Xaa Leu Ala Val Glu Arg Leu Leu Glu Pro Leu 
            20                  25                  30          


Val Xaa Gln Val Xaa Xaa Leu Val Asn Xaa Asn Ser Lys Gly Pro Ser 
        35                  40                  45              


Asn Lys Lys Arg Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser 
    50                  55                  60                  


Val Glu Gln Ala Xaa Glu Asn Phe Leu Glu Lys Gly Asp Lys Ile Ala 
65                  70                  75                  80  


Lys Glu Ser Gln Phe Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp 
                85                  90                  95      


Val Arg Lys Gln Gly Asp Leu Met Lys Ala Ala Ala Gly Glu Phe Ala 
            100                 105                 110         


Asp Asp Pro Cys Ser Ser Val Lys Arg Gly Asn 
        115                 120             


<210> 7215
<211> 139
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 7215
Met Xaa Ala Val His Ala Gly Asn Ile Asn Phe Lys Trp Asp Pro Lys 
1               5                   10                  15      


Ser Leu Glu Ile Arg Xaa Leu Ala Val Glu Arg Leu Leu Glu Pro Leu 
            20                  25                  30          


Val Xaa Gln Val Xaa Xaa Leu Val Asn Xaa Asn Ser Lys Gly Pro Ser 
        35                  40                  45              


Asn Lys Lys Arg Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser 
    50                  55                  60                  


Val Glu Gln Ala Xaa Glu Asn Phe Leu Glu Lys Gly Asp Lys Ile Ala 
65                  70                  75                  80  


Lys Glu Ser Gln Phe Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp 
                85                  90                  95      


Val Arg Lys Gln Gly Asp Leu Met Lys Ala Ala Ala Gly Glu Phe Ala 
            100                 105                 110         


Asp Asp Pro Cys Ser Ser Val Lys Arg Gly Asn Met Val Arg Ala Ala 
        115                 120                 125             


Arg Ala Leu Leu Ser Ala Val Xaa Arg Leu Leu 
    130                 135                 


<210> 7216
<211> 156
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 7216
Met Xaa Ala Val His Ala Gly Asn Ile Asn Phe Lys Trp Asp Pro Lys 
1               5                   10                  15      


Ser Leu Glu Ile Arg Xaa Leu Ala Val Glu Arg Leu Leu Glu Pro Leu 
            20                  25                  30          


Val Xaa Gln Val Xaa Xaa Leu Val Asn Xaa Asn Ser Lys Gly Pro Ser 
        35                  40                  45              


Asn Lys Lys Arg Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser 
    50                  55                  60                  


Val Glu Gln Ala Xaa Glu Asn Phe Leu Glu Lys Gly Asp Lys Ile Ala 
65                  70                  75                  80  


Lys Glu Ser Gln Phe Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp 
                85                  90                  95      


Val Arg Lys Gln Gly Asp Leu Met Lys Ala Ala Ala Gly Glu Phe Ala 
            100                 105                 110         


Asp Asp Pro Cys Ser Ser Val Lys Arg Gly Asn Met Val Arg Ala Ala 
        115                 120                 125             


Arg Ala Leu Leu Ser Ala Val Xaa Arg Leu Leu Ile Leu Ala Asp Met 
    130                 135                 140                 


Ala Asp Val Tyr Lys Leu Leu Val Gln Leu Lys Val 
145                 150                 155     


<210> 7217
<211> 215
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<400> 7217
Met Xaa Ala Val His Ala Gly Asn Ile Asn Phe Lys Trp Asp Pro Lys 
1               5                   10                  15      


Ser Leu Glu Ile Arg Xaa Leu Ala Val Glu Arg Leu Leu Glu Pro Leu 
            20                  25                  30          


Val Xaa Gln Val Xaa Xaa Leu Val Asn Xaa Asn Ser Lys Gly Pro Ser 
        35                  40                  45              


Asn Lys Lys Arg Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser 
    50                  55                  60                  


Val Glu Gln Ala Xaa Glu Asn Phe Leu Glu Lys Gly Asp Lys Ile Ala 
65                  70                  75                  80  


Lys Glu Ser Gln Phe Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp 
                85                  90                  95      


Val Arg Lys Gln Gly Asp Leu Met Lys Ala Ala Ala Gly Glu Phe Ala 
            100                 105                 110         


Asp Asp Pro Cys Ser Ser Val Lys Arg Gly Asn Met Val Arg Ala Ala 
        115                 120                 125             


Arg Ala Leu Leu Ser Ala Val Xaa Arg Leu Leu Ile Leu Ala Asp Met 
    130                 135                 140                 


Ala Asp Val Tyr Lys Leu Leu Val Gln Leu Lys Val Val Glu Asp Gly 
145                 150                 155                 160 


Ile Leu Lys Leu Arg Asn Ala Gly Asn Glu Gln Asp Leu Gly Ile Gln 
                165                 170                 175     


Tyr Lys Ala Leu Lys Pro Glu Val Asp Lys Leu Asn Ile Met Ala Ala 
            180                 185                 190         


Lys Arg Gln Gln Glu Leu Lys Asp Val Gly His Arg Asp Gln Met Ala 
        195                 200                 205             


Ala Ala Arg Gly Ile Leu Gln 
    210                 215 


<210> 7218
<211> 841
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<400> 7218
Met Xaa Ala Val His Ala Gly Asn Ile Asn Phe Lys Trp Asp Pro Lys 
1               5                   10                  15      


Ser Leu Glu Ile Arg Xaa Leu Ala Val Glu Arg Leu Leu Glu Pro Leu 
            20                  25                  30          


Val Xaa Gln Val Xaa Xaa Leu Val Asn Xaa Asn Ser Lys Gly Pro Ser 
        35                  40                  45              


Asn Lys Lys Arg Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser 
    50                  55                  60                  


Val Glu Gln Ala Xaa Glu Asn Phe Leu Glu Lys Gly Asp Lys Ile Ala 
65                  70                  75                  80  


Lys Glu Ser Gln Phe Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp 
                85                  90                  95      


Val Arg Lys Gln Gly Asp Leu Met Lys Ala Ala Ala Gly Glu Phe Ala 
            100                 105                 110         


Asp Asp Pro Cys Ser Ser Val Lys Arg Gly Asn Met Val Arg Ala Ala 
        115                 120                 125             


Arg Ala Leu Leu Ser Ala Val Xaa Arg Leu Leu Ile Leu Ala Asp Met 
    130                 135                 140                 


Ala Asp Val Tyr Lys Leu Leu Val Gln Leu Lys Val Val Glu Asp Gly 
145                 150                 155                 160 


Ile Leu Lys Leu Arg Asn Ala Gly Asn Glu Gln Asp Leu Gly Ile Gln 
                165                 170                 175     


Tyr Lys Ala Leu Lys Pro Glu Val Asp Lys Leu Asn Ile Met Ala Ala 
            180                 185                 190         


Lys Arg Gln Gln Glu Leu Lys Asp Val Gly His Arg Asp Gln Met Ala 
        195                 200                 205             


Ala Ala Arg Gly Ile Leu Gln Lys Asn Val Pro Ile Leu Tyr Xaa Ala 
    210                 215                 220                 


Ser Gln Ala Cys Leu Gln His Pro Asp Val Ala Ala Tyr Lys Ala Asn 
225                 230                 235                 240 


Arg Asp Leu Ile Tyr Lys Gln Leu Gln Gln Ala Val Xaa Gly Ile Ser 
                245                 250                 255     


Asn Ala Ala Gln Ala Xaa Ala Ser Asp Asp Ala Ser Gln His Gln Gly 
            260                 265                 270         


Gly Gly Gly Gly Glu Leu Ala Tyr Ala Leu Asn Asn Phe Asp Lys Gln 
        275                 280                 285             


Ile Ile Val Asp Pro Leu Ser Phe Ser Glu Glu Arg Phe Arg Pro Ser 
    290                 295                 300                 


Leu Glu Glu Arg Leu Glu Ser Ile Ile Ser Gly Ala Ala Leu Met Ala 
305                 310                 315                 320 


Asp Ser Ser Cys Xaa Arg Asp Asp Arg Arg Glu Arg Ile Val Ala Glu 
                325                 330                 335     


Cys Asn Ala Val Arg Gln Ala Leu Gln Asp Leu Leu Ser Glu Tyr Met 
            340                 345                 350         


Gly Asn Ala Gly Arg Lys Glu Arg Ser Asp Ala Leu Asn Ser Ala Ile 
        355                 360                 365             


Asp Lys Met Xaa Lys Lys Xaa Arg Asp Leu Arg Arg Gln Leu Arg Lys 
    370                 375                 380                 


Ala Val Met Asp His Val Ser Asp Ser Phe Leu Glu Xaa Asn Val Pro 
385                 390                 395                 400 


Leu Leu Val Leu Ile Glu Ala Ala Lys Asn Gly Asn Glu Lys Glu Val 
                405                 410                 415     


Lys Glu Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Ile Glu 
            420                 425                 430         


Val Ala Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys 
        435                 440                 445             


Leu Val Arg Met Ser Ala Ser Gln Leu Glu Ala Leu Cys Pro Gln Val 
    450                 455                 460                 


Ile Asn Ala Ala Leu Ala Leu Ala Ala Lys Pro Gln Ser Lys Leu Ala 
465                 470                 475                 480 


Gln Glu Asn Met Asp Leu Phe Lys Glu Gln Trp Glu Lys Gln Val Arg 
                485                 490                 495     


Val Leu Xaa Asp Ala Val Asp Asp Ile Xaa Ser Ile Asp Asp Phe Leu 
            500                 505                 510         


Ala Val Ser Glu Asn His Ile Leu Glu Asp Val Asn Lys Cys Val Ile 
        515                 520                 525             


Ala Leu Gln Glu Lys Asp Val Asp Gly Leu Asp Arg Xaa Ala Gly Ala 
    530                 535                 540                 


Ile Arg Gly Arg Ala Ala Arg Val Ile His Val Val Xaa Ser Glu Met 
545                 550                 555                 560 


Asp Asn Tyr Glu Pro Gly Val Tyr Xaa Glu Lys Val Leu Glu Ala Xaa 
                565                 570                 575     


Lys Leu Leu Ser Asn Xaa Val Met Pro Arg Phe Xaa Glu Gln Val Glu 
            580                 585                 590         


Ala Ala Val Glu Ala Leu Ser Ser Asp Pro Ala Gln Pro Met Asp Glu 
        595                 600                 605             


Asn Glu Phe Ile Asp Ala Ser Arg Leu Val Tyr Asp Gly Ile Arg Asp 
    610                 615                 620                 


Ile Arg Lys Ala Val Leu Met Ile Arg Xaa Pro Glu Glu Leu Asp Asp 
625                 630                 635                 640 


Ser Asp Phe Glu Xaa Glu Asp Phe Asp Val Arg Ser Arg Xaa Ser Val 
                645                 650                 655     


Gln Xaa Glu Asp Asp Gln Leu Ile Ala Gly Gln Ser Ala Arg Ala Ile 
            660                 665                 670         


Met Ala Gln Leu Pro Gln Glu Gln Lys Ala Lys Ile Ala Glu Gln Val 
        675                 680                 685             


Ala Ser Phe Gln Glu Glu Lys Ser Lys Leu Asp Ala Glu Val Ser Lys 
    690                 695                 700                 


Trp Asp Asp Ser Gly Asn Asp Ile Ile Val Leu Ala Lys Gln Met Cys 
705                 710                 715                 720 


Met Ile Met Met Glu Met Xaa Asp Phe Xaa Arg Gly Lys Gly Pro Leu 
                725                 730                 735     


Lys Asn Xaa Ser Asp Val Ile Ser Ala Ala Lys Lys Ile Ala Glu Ala 
            740                 745                 750         


Gly Ser Arg Met Asp Lys Leu Gly Arg Xaa Ile Ala Asp His Cys Pro 
        755                 760                 765             


Asp Ser Ala Cys Lys Gln Asp Leu Leu Ala Tyr Leu Gln Arg Ile Ala 
    770                 775                 780                 


Leu Tyr Cys His Gln Leu Asn Ile Cys Ser Lys Val Lys Ala Glu Val 
785                 790                 795                 800 


Gln Asn Leu Gly Gly Glu Leu Val Val Ser Gly Asn Cys Asp Xaa Cys 
                805                 810                 815     


Gly Ala Leu Gln Gly Leu Lys Gly Trp Pro Pro Pro Leu Cys Trp Pro 
            820                 825                 830         


Leu Xaa Gly Trp Xaa Ala Pro Cys Pro 
        835                 840     


<210> 7219
<211> 906
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (569)..(569)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<400> 7219
Met Xaa Ala Val His Ala Gly Asn Ile Asn Phe Lys Trp Asp Pro Lys 
1               5                   10                  15      


Ser Leu Glu Ile Arg Xaa Leu Ala Val Glu Arg Leu Leu Glu Pro Leu 
            20                  25                  30          


Val Xaa Gln Val Xaa Xaa Leu Val Asn Xaa Asn Ser Lys Gly Pro Ser 
        35                  40                  45              


Asn Lys Lys Arg Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser 
    50                  55                  60                  


Val Glu Gln Ala Xaa Glu Asn Phe Leu Glu Lys Gly Asp Lys Ile Ala 
65                  70                  75                  80  


Lys Glu Ser Gln Phe Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp 
                85                  90                  95      


Val Arg Lys Gln Gly Asp Leu Met Lys Ala Ala Ala Gly Glu Phe Ala 
            100                 105                 110         


Asp Asp Pro Cys Ser Ser Val Lys Arg Gly Asn Met Val Arg Ala Ala 
        115                 120                 125             


Arg Ala Leu Leu Ser Ala Val Xaa Arg Leu Leu Ile Leu Ala Asp Met 
    130                 135                 140                 


Ala Asp Val Tyr Lys Leu Leu Val Gln Leu Lys Val Val Glu Asp Gly 
145                 150                 155                 160 


Ile Leu Lys Leu Arg Asn Ala Gly Asn Glu Gln Asp Leu Gly Ile Gln 
                165                 170                 175     


Tyr Lys Ala Leu Lys Pro Glu Val Asp Lys Leu Asn Ile Met Ala Ala 
            180                 185                 190         


Lys Arg Gln Gln Glu Leu Lys Asp Val Gly His Arg Asp Gln Met Ala 
        195                 200                 205             


Ala Ala Arg Gly Ile Leu Gln Lys Asn Val Pro Ile Leu Tyr Xaa Ala 
    210                 215                 220                 


Ser Gln Ala Cys Leu Gln His Pro Asp Val Ala Ala Tyr Lys Ala Asn 
225                 230                 235                 240 


Arg Asp Leu Ile Tyr Lys Gln Leu Gln Gln Ala Val Xaa Gly Ile Ser 
                245                 250                 255     


Asn Ala Ala Gln Ala Xaa Ala Ser Asp Asp Ala Ser Gln His Gln Gly 
            260                 265                 270         


Gly Gly Gly Gly Glu Leu Ala Tyr Ala Leu Asn Asn Phe Asp Lys Gln 
        275                 280                 285             


Ile Ile Val Asp Pro Leu Ser Phe Ser Glu Glu Arg Phe Arg Pro Ser 
    290                 295                 300                 


Leu Glu Glu Arg Leu Glu Ser Ile Ile Ser Gly Ala Ala Leu Met Ala 
305                 310                 315                 320 


Asp Ser Ser Cys Xaa Arg Asp Asp Arg Arg Glu Arg Ile Val Ala Glu 
                325                 330                 335     


Cys Asn Ala Val Arg Gln Ala Leu Gln Asp Leu Leu Ser Glu Tyr Met 
            340                 345                 350         


Gly Asn Ala Gly Arg Lys Glu Arg Ser Asp Ala Leu Asn Ser Ala Ile 
        355                 360                 365             


Asp Lys Met Xaa Lys Lys Xaa Arg Asp Leu Arg Arg Gln Leu Arg Lys 
    370                 375                 380                 


Ala Val Met Asp His Val Ser Asp Ser Phe Leu Glu Xaa Asn Val Pro 
385                 390                 395                 400 


Leu Leu Val Leu Ile Glu Ala Ala Lys Asn Gly Asn Glu Lys Glu Val 
                405                 410                 415     


Lys Glu Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Ile Glu 
            420                 425                 430         


Val Ala Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys 
        435                 440                 445             


Leu Val Arg Met Ser Ala Ser Gln Leu Glu Ala Leu Cys Pro Gln Val 
    450                 455                 460                 


Ile Asn Ala Ala Leu Ala Leu Ala Ala Lys Pro Gln Ser Lys Leu Ala 
465                 470                 475                 480 


Gln Glu Asn Met Asp Leu Phe Lys Glu Gln Trp Glu Lys Gln Val Arg 
                485                 490                 495     


Val Leu Xaa Asp Ala Val Asp Asp Ile Xaa Ser Ile Asp Asp Phe Leu 
            500                 505                 510         


Ala Val Ser Glu Asn His Ile Leu Glu Asp Val Asn Lys Cys Val Ile 
        515                 520                 525             


Ala Leu Gln Glu Lys Asp Val Asp Gly Leu Asp Arg Xaa Ala Gly Ala 
    530                 535                 540                 


Ile Arg Gly Arg Ala Ala Arg Val Ile His Val Val Xaa Ser Glu Met 
545                 550                 555                 560 


Asp Asn Tyr Glu Pro Gly Val Tyr Xaa Glu Lys Val Leu Glu Ala Xaa 
                565                 570                 575     


Lys Leu Leu Ser Asn Xaa Val Met Pro Arg Phe Xaa Glu Gln Val Glu 
            580                 585                 590         


Ala Ala Val Glu Ala Leu Ser Ser Asp Pro Ala Gln Pro Met Asp Glu 
        595                 600                 605             


Asn Glu Phe Ile Asp Ala Ser Arg Leu Val Tyr Asp Gly Ile Arg Asp 
    610                 615                 620                 


Ile Arg Lys Ala Val Leu Met Ile Arg Xaa Pro Glu Glu Leu Asp Asp 
625                 630                 635                 640 


Ser Asp Phe Glu Xaa Glu Asp Phe Asp Val Arg Ser Arg Xaa Ser Val 
                645                 650                 655     


Gln Xaa Glu Asp Asp Gln Leu Ile Ala Gly Gln Ser Ala Arg Ala Ile 
            660                 665                 670         


Met Ala Gln Leu Pro Gln Glu Gln Lys Ala Lys Ile Ala Glu Gln Val 
        675                 680                 685             


Ala Ser Phe Gln Glu Glu Lys Ser Lys Leu Asp Ala Glu Val Ser Lys 
    690                 695                 700                 


Trp Asp Asp Ser Gly Asn Asp Ile Ile Val Leu Ala Lys Gln Met Cys 
705                 710                 715                 720 


Met Ile Met Met Glu Met Xaa Asp Phe Xaa Arg Gly Lys Gly Pro Leu 
                725                 730                 735     


Lys Asn Xaa Ser Asp Val Ile Ser Ala Ala Lys Lys Ile Ala Glu Ala 
            740                 745                 750         


Gly Ser Arg Met Asp Lys Leu Gly Arg Xaa Ile Ala Asp His Cys Pro 
        755                 760                 765             


Asp Ser Ala Cys Lys Gln Asp Leu Leu Ala Tyr Leu Gln Arg Ile Ala 
    770                 775                 780                 


Leu Tyr Cys His Gln Leu Asn Ile Cys Ser Lys Val Lys Ala Glu Val 
785                 790                 795                 800 


Gln Asn Leu Gly Gly Glu Leu Val Val Ser Gly Val Asp Ser Ala Met 
                805                 810                 815     


Ser Leu Ile Gln Ala Ala Lys Asn Leu Met Asn Ala Val Val Gln Xaa 
            820                 825                 830         


Val Lys Ala Ser Tyr Val Ala Ser Xaa Lys Tyr Gln Lys Ser Gln Gly 
        835                 840                 845             


Met Ala Ser Leu Asn Leu Pro Ala Val Ser Trp Lys Met Lys Ala Pro 
    850                 855                 860                 


Glu Lys Lys Pro Leu Val Lys Arg Glu Lys Gln Asp Glu Xaa Gln Xaa 
865                 870                 875                 880 


Lys Ile Lys Arg Ala Ser Gln Lys Lys His Val Asn Pro Val Gln Ala 
                885                 890                 895     


Leu Ser Glu Phe Lys Ala Met Asp Ser Ile 
            900                 905     


<210> 7220
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<400> 7220
Met Xaa Asp Phe Xaa Arg Gly Lys Gly Pro Leu Lys Asn Xaa Ser Asp 
1               5                   10                  15      


Val Ile Ser Ala Ala Lys Lys Ile Ala Glu Ala Gly Ser Arg Met Asp 
            20                  25                  30          


Lys Leu Gly Arg Xaa Ile Ala Asp His Val Asp Ser Ala Met Ser Leu 
        35                  40                  45              


Ile Gln Ala Ala Lys Asn Leu Met Asn Ala Val Val Gln Xaa Val Lys 
    50                  55                  60                  


Ala Ser Tyr Val Ala Ser Xaa Lys Tyr Gln Lys Ser Gln Gly Met Ala 
65                  70                  75                  80  


Ser Leu Asn Leu Pro Ala Val Ser Trp Lys Met Lys Ala Pro Glu Lys 
                85                  90                  95      


Lys Pro Leu Val Lys Arg Glu Lys Gln Asp Glu Xaa Gln Xaa Lys Ile 
            100                 105                 110         


Lys Arg Ala Ser Gln Lys Lys His Val Asn Pro Val Gln Ala Leu Ser 
        115                 120                 125             


Glu Phe Lys Ala Met Asp Ser Ile 
    130                 135     


<210> 7221
<211> 20
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<400> 7221
Met Xaa Lys Lys Xaa Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val 
1               5                   10                  15      


Met Asp His Val 
            20  


<210> 7222
<211> 32
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 7222
Met Xaa Lys Lys Xaa Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val 
1               5                   10                  15      


Met Asp His Val Ser Asp Ser Phe Leu Glu Xaa Asn Val Pro Leu Leu 
            20                  25                  30          


<210> 7223
<211> 37
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 7223
Met Xaa Lys Lys Xaa Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val 
1               5                   10                  15      


Met Asp His Val Ser Asp Ser Phe Leu Glu Xaa Asn Val Pro Leu Leu 
            20                  25                  30          


Val Leu Ile Glu Ala 
        35          


<210> 7224
<211> 39
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 7224
Met Xaa Lys Lys Xaa Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val 
1               5                   10                  15      


Met Asp His Val Ser Asp Ser Phe Leu Glu Xaa Asn Val Pro Leu Leu 
            20                  25                  30          


Val Leu Ile Glu Ala Ala Lys 
        35                  


<210> 7225
<211> 41
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 7225
Met Xaa Lys Lys Xaa Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val 
1               5                   10                  15      


Met Asp His Val Ser Asp Ser Phe Leu Glu Xaa Asn Val Pro Leu Leu 
            20                  25                  30          


Val Leu Ile Glu Ala Ala Lys Asn Gly 
        35                  40      


<210> 7226
<211> 50
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 7226
Met Xaa Lys Lys Xaa Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val 
1               5                   10                  15      


Met Asp His Val Ser Asp Ser Phe Leu Glu Xaa Asn Val Pro Leu Leu 
            20                  25                  30          


Val Leu Ile Glu Ala Ala Lys Asn Gly Asn Glu Lys Glu Val Lys Glu 
        35                  40                  45              


Tyr Ala 
    50  


<210> 7227
<211> 64
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 7227
Met Xaa Lys Lys Xaa Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val 
1               5                   10                  15      


Met Asp His Val Ser Asp Ser Phe Leu Glu Xaa Asn Val Pro Leu Leu 
            20                  25                  30          


Val Leu Ile Glu Ala Ala Lys Asn Gly Asn Glu Lys Glu Val Lys Glu 
        35                  40                  45              


Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Ile Glu Gly Ile 
    50                  55                  60                  


<210> 7228
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 7228
Met Xaa Lys Lys Xaa Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val 
1               5                   10                  15      


Met Asp His Val Ser Asp Ser Phe Leu Glu Xaa Asn Val Pro Leu Leu 
            20                  25                  30          


Val Leu Ile Glu Ala Ala Lys Asn Gly Asn Glu Lys Glu Val Lys Glu 
        35                  40                  45              


Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Ile Glu Val Ala 
    50                  55                  60                  


Asn Leu Ala Cys Ser Ile Ser 
65                  70      


<210> 7229
<211> 75
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 7229
Met Xaa Lys Lys Xaa Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val 
1               5                   10                  15      


Met Asp His Val Ser Asp Ser Phe Leu Glu Xaa Asn Val Pro Leu Leu 
            20                  25                  30          


Val Leu Ile Glu Ala Ala Lys Asn Gly Asn Glu Lys Glu Val Lys Glu 
        35                  40                  45              


Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Ile Glu Val Ala 
    50                  55                  60                  


Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu 
65                  70                  75  


<210> 7230
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 7230
Met Xaa Lys Lys Xaa Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val 
1               5                   10                  15      


Met Asp His Val Ser Asp Ser Phe Leu Glu Xaa Asn Val Pro Leu Leu 
            20                  25                  30          


Val Leu Ile Glu Ala Ala Lys Asn Gly Asn Glu Lys Glu Val Lys Glu 
        35                  40                  45              


Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Ile Glu Val Ala 
    50                  55                  60                  


Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys Leu Val 
65                  70                  75                  80  


Arg Met Ser Ala Ser Gln Leu Glu Ala Leu Cys Pro 
                85                  90          


<210> 7231
<211> 105
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 7231
Met Xaa Lys Lys Xaa Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val 
1               5                   10                  15      


Met Asp His Val Ser Asp Ser Phe Leu Glu Xaa Asn Val Pro Leu Leu 
            20                  25                  30          


Val Leu Ile Glu Ala Ala Lys Asn Gly Asn Glu Lys Glu Val Lys Glu 
        35                  40                  45              


Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Ile Glu Val Ala 
    50                  55                  60                  


Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys Leu Val 
65                  70                  75                  80  


Arg Met Ser Ala Ser Gln Leu Glu Ala Leu Cys Pro Gln Val Ile Asn 
                85                  90                  95      


Ala Ala Leu Ala Leu Ala Ala Lys Pro 
            100                 105 


<210> 7232
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 7232
Met Xaa Lys Lys Xaa Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val 
1               5                   10                  15      


Met Asp His Val Ser Asp Ser Phe Leu Glu Xaa Asn Val Pro Leu Leu 
            20                  25                  30          


Val Leu Ile Glu Ala Ala Lys Asn Gly Asn Glu Lys Glu Val Lys Glu 
        35                  40                  45              


Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Ile Glu Val Ala 
    50                  55                  60                  


Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys Leu Val 
65                  70                  75                  80  


Arg Met Ser Ala Ser Gln Leu Glu Ala Leu Cys Pro Gln Val Ile Asn 
                85                  90                  95      


Ala Ala Leu Ala Leu Ala Ala Lys Pro Gln Ser Lys Leu Ala 
            100                 105                 110 


<210> 7233
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 7233
Met Xaa Lys Lys Xaa Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val 
1               5                   10                  15      


Met Asp His Val Ser Asp Ser Phe Leu Glu Xaa Asn Val Pro Leu Leu 
            20                  25                  30          


Val Leu Ile Glu Ala Ala Lys Asn Gly Asn Glu Lys Glu Val Lys Glu 
        35                  40                  45              


Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Ile Glu Val Ala 
    50                  55                  60                  


Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys Leu Val 
65                  70                  75                  80  


Arg Met Ser Ala Ser Gln Leu Glu Ala Leu Cys Pro Gln Val Ile Asn 
                85                  90                  95      


Ala Ala Leu Ala Leu Ala Ala Lys Pro Gln Ser Lys Leu Ala Gln Glu 
            100                 105                 110         


Asn Met Asp Leu Phe Lys Glu 
        115                 


<210> 7234
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<400> 7234
Met Xaa Lys Lys Xaa Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val 
1               5                   10                  15      


Met Asp His Val Ser Asp Ser Phe Leu Glu Xaa Asn Val Pro Leu Leu 
            20                  25                  30          


Val Leu Ile Glu Ala Ala Lys Asn Gly Asn Glu Lys Glu Val Lys Glu 
        35                  40                  45              


Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Ile Glu Val Ala 
    50                  55                  60                  


Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys Leu Val 
65                  70                  75                  80  


Arg Met Ser Ala Ser Gln Leu Glu Ala Leu Cys Pro Gln Val Ile Asn 
                85                  90                  95      


Ala Ala Leu Ala Leu Ala Ala Lys Pro Gln Ser Lys Leu Ala Gln Glu 
            100                 105                 110         


Asn Met Asp Leu Phe Lys Glu Gln Trp Glu Lys Gln Val Arg Val Leu 
        115                 120                 125             


<210> 7235
<211> 536
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<400> 7235
Met Xaa Lys Lys Xaa Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val 
1               5                   10                  15      


Met Asp His Val Ser Asp Ser Phe Leu Glu Xaa Asn Val Pro Leu Leu 
            20                  25                  30          


Val Leu Ile Glu Ala Ala Lys Asn Gly Asn Glu Lys Glu Val Lys Glu 
        35                  40                  45              


Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Ile Glu Val Ala 
    50                  55                  60                  


Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys Leu Val 
65                  70                  75                  80  


Arg Met Ser Ala Ser Gln Leu Glu Ala Leu Cys Pro Gln Val Ile Asn 
                85                  90                  95      


Ala Ala Leu Ala Leu Ala Ala Lys Pro Gln Ser Lys Leu Ala Gln Glu 
            100                 105                 110         


Asn Met Asp Leu Phe Lys Glu Gln Trp Glu Lys Gln Val Arg Val Leu 
        115                 120                 125             


Xaa Asp Ala Val Asp Asp Ile Xaa Ser Ile Asp Asp Phe Leu Ala Val 
    130                 135                 140                 


Ser Glu Asn His Ile Leu Glu Asp Val Asn Lys Cys Val Ile Ala Leu 
145                 150                 155                 160 


Gln Glu Lys Asp Val Asp Gly Leu Asp Arg Xaa Ala Gly Ala Ile Arg 
                165                 170                 175     


Gly Arg Ala Ala Arg Val Ile His Val Val Xaa Ser Glu Met Asp Asn 
            180                 185                 190         


Tyr Glu Pro Gly Val Tyr Xaa Glu Lys Val Leu Glu Ala Xaa Lys Leu 
        195                 200                 205             


Leu Ser Asn Xaa Val Met Pro Arg Phe Xaa Glu Gln Val Glu Ala Ala 
    210                 215                 220                 


Val Glu Ala Leu Ser Ser Asp Pro Ala Gln Pro Met Asp Glu Asn Glu 
225                 230                 235                 240 


Phe Ile Asp Ala Ser Arg Leu Val Tyr Asp Gly Ile Arg Asp Ile Arg 
                245                 250                 255     


Lys Ala Val Leu Met Ile Arg Xaa Pro Glu Glu Leu Asp Asp Ser Asp 
            260                 265                 270         


Phe Glu Xaa Glu Asp Phe Asp Val Arg Ser Arg Xaa Ser Val Gln Xaa 
        275                 280                 285             


Glu Asp Asp Gln Leu Ile Ala Gly Gln Ser Ala Arg Ala Ile Met Ala 
    290                 295                 300                 


Gln Leu Pro Gln Glu Gln Lys Ala Lys Ile Ala Glu Gln Val Ala Ser 
305                 310                 315                 320 


Phe Gln Glu Glu Lys Ser Lys Leu Asp Ala Glu Val Ser Lys Trp Asp 
                325                 330                 335     


Asp Ser Gly Asn Asp Ile Ile Val Leu Ala Lys Gln Met Cys Met Ile 
            340                 345                 350         


Met Met Glu Met Xaa Asp Phe Xaa Arg Gly Lys Gly Pro Leu Lys Asn 
        355                 360                 365             


Xaa Ser Asp Val Ile Ser Ala Ala Lys Lys Ile Ala Glu Ala Gly Ser 
    370                 375                 380                 


Arg Met Asp Lys Leu Gly Arg Xaa Ile Ala Asp His Cys Pro Asp Ser 
385                 390                 395                 400 


Ala Cys Lys Gln Asp Leu Leu Ala Tyr Leu Gln Arg Ile Ala Leu Tyr 
                405                 410                 415     


Cys His Gln Leu Asn Ile Cys Ser Lys Val Lys Ala Glu Val Gln Asn 
            420                 425                 430         


Leu Gly Gly Glu Leu Val Val Ser Gly Val Asp Ser Ala Met Ser Leu 
        435                 440                 445             


Ile Gln Ala Ala Lys Asn Leu Met Asn Ala Val Val Gln Xaa Val Lys 
    450                 455                 460                 


Ala Ser Tyr Val Ala Ser Xaa Lys Tyr Gln Lys Ser Gln Gly Met Ala 
465                 470                 475                 480 


Ser Leu Asn Leu Pro Ala Val Ser Trp Lys Met Lys Ala Pro Glu Lys 
                485                 490                 495     


Lys Pro Leu Val Lys Arg Glu Lys Gln Asp Glu Xaa Gln Xaa Lys Ile 
            500                 505                 510         


Lys Arg Ala Ser Gln Lys Lys His Val Asn Pro Val Gln Ala Leu Ser 
        515                 520                 525             


Glu Phe Lys Ala Met Asp Ser Ile 
    530                 535     


<210> 7236
<211> 22
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<400> 7236
Xaa Val Arg Met Ser Ala Ser Gln Leu Glu Ala Leu Cys Pro Gln Arg 
1               5                   10                  15      


Ile Xaa Phe Trp Lys Met 
            20          


<210> 7237
<211> 183
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<400> 7237
Met Ala Ala Ser Pro Gly Pro Ala Gly Val Gly Gly Ala Gly Ala Val 
1               5                   10                  15      


Tyr Gly Ser Gly Ser Ser Gly Phe Ala Leu Asp Ser Gly Leu Glu Ile 
            20                  25                  30          


Lys Xaa Arg Ser Val Glu Gln Xaa Leu Leu Pro Leu Val Ser Gln Ile 
        35                  40                  45              


Xaa Xaa Leu Ile Asn His Lys Asp Asn Xaa Lys Lys Ser Asp Lys Xaa 
    50                  55                  60                  


Leu Gln Ala Ile Gln Arg Val Gly Gln Ala Val Asn Leu Ala Val Gly 
65                  70                  75                  80  


Arg Phe Val Lys Val Gly Glu Ala Ile Ala Asn Glu Asn Trp Asp Leu 
                85                  90                  95      


Lys Glu Glu Ile Asn Ile Ala Cys Ile Glu Ala Lys Gln Ala Gly Glu 
            100                 105                 110         


Xaa Ile Ala Ala Leu Xaa Asp Ile Xaa Asn Leu Asn His Leu Glu Ser 
        115                 120                 125             


Asp Gly Gln Ile Xaa Ile Phe Xaa Asp Lys Xaa Gly Val Ile Lys Ala 
    130                 135                 140                 


Ala Arg Leu Leu Leu Ser Ser Val Xaa Lys Val Leu Leu Leu Ala Asp 
145                 150                 155                 160 


Arg Val Val Ile Lys Gln Ile Ile Xaa Ser Arg Asn Lys Arg Leu Xaa 
                165                 170                 175     


Ile Tyr Asn Leu Arg His Ser 
            180             


<210> 7238
<211> 718
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<400> 7238
Met Ala Ala Ser Pro Gly Pro Ala Gly Val Gly Gly Ala Gly Ala Val 
1               5                   10                  15      


Tyr Gly Ser Gly Ser Ser Gly Phe Ala Leu Asp Ser Gly Leu Glu Ile 
            20                  25                  30          


Lys Xaa Arg Ser Val Glu Gln Xaa Leu Leu Pro Leu Val Ser Gln Ile 
        35                  40                  45              


Xaa Xaa Leu Ile Asn His Lys Asp Asn Xaa Lys Lys Ser Asp Lys Xaa 
    50                  55                  60                  


Leu Gln Ala Ile Gln Arg Val Gly Gln Ala Val Asn Leu Ala Val Gly 
65                  70                  75                  80  


Arg Phe Val Lys Val Gly Glu Ala Ile Ala Asn Glu Asn Trp Asp Leu 
                85                  90                  95      


Lys Glu Glu Ile Asn Ile Ala Cys Ile Glu Ala Lys Gln Ala Gly Glu 
            100                 105                 110         


Xaa Ile Ala Ala Leu Xaa Asp Ile Xaa Asn Leu Asn His Leu Glu Ser 
        115                 120                 125             


Asp Gly Gln Ile Xaa Ile Phe Xaa Asp Lys Xaa Gly Val Ile Lys Ala 
    130                 135                 140                 


Ala Arg Leu Leu Leu Ser Ser Val Xaa Lys Val Leu Leu Leu Ala Asp 
145                 150                 155                 160 


Arg Val Val Ile Lys Gln Ile Ile Xaa Ser Arg Asn Lys Val Leu Ala 
                165                 170                 175     


Xaa Met Glu Arg Leu Glu Lys Val Asn Ser Phe Gln Glu Phe Val Gln 
            180                 185                 190         


Ile Phe Ser Gln Phe Gly Asn Glu Met Val Glu Phe Ala His Leu Ser 
        195                 200                 205             


Gly Asp Arg Gln Asn Asp Leu Lys Asp Glu Lys Lys Lys Ala Lys Met 
    210                 215                 220                 


Ala Ala Ala Arg Ala Val Leu Glu Lys Cys Xaa Met Met Leu Leu Xaa 
225                 230                 235                 240 


Ala Ser Lys Xaa Cys Leu Arg His Pro Asn Cys Glu Ser Ala His Lys 
                245                 250                 255     


Asn Lys Glu Gly Val Phe Asp Arg Met Lys Val Ala Leu Asp Lys Val 
            260                 265                 270         


Ile Glu Ile Val Xaa Asp Cys Lys Pro Asn Gly Glu Xaa Asp Ile Ser 
        275                 280                 285             


Ser Ile Ser Ile Phe Xaa Gly Ile Lys Glu Phe Lys Met Asn Ile Glu 
    290                 295                 300                 


Ala Leu Arg Glu Asn Leu Tyr Phe Gln Ser Lys Glu Asn Leu Ser Val 
305                 310                 315                 320 


Xaa Leu Glu Val Ile Leu Glu Arg Met Glu Asp Phe Xaa Asp Ser Ala 
                325                 330                 335     


Tyr Xaa Ser His Glu His Arg Glu Arg Ile Leu Glu Leu Ser Xaa Gln 
            340                 345                 350         


Ala Arg Met Glu Leu Gln Gln Leu Ile Ser Val Trp Ile Gln Ala Gln 
        355                 360                 365             


Ser Lys Lys Xaa Lys Ser Ile Ala Glu Glu Leu Glu Leu Ser Ile Leu 
    370                 375                 380                 


Lys Ile Ser His Ser Leu Asn Glu Leu Lys Lys Glu Leu His Ser Xaa 
385                 390                 395                 400 


Ala Xaa Gln Leu Ala Ala Asp Leu Leu Lys Tyr His Ala Asp His Val 
                405                 410                 415     


Val Leu Lys Ala Leu Lys Leu Xaa Gly Val Glu Gly Asn Leu Glu Ala 
            420                 425                 430         


Leu Ala Glu Tyr Ala Cys Lys Leu Ser Glu Gln Lys Glu Gln Leu Val 
        435                 440                 445             


Glu Xaa Cys Arg Leu Leu Arg His Ile Ser Gly Xaa Glu Pro Leu Glu 
    450                 455                 460                 


Ile Xaa Cys Ile His Ala Glu Glu Xaa Phe Gln Val Xaa Gly Gln Gln 
465                 470                 475                 480 


Ile Ile Ser Ala Ala Glu Xaa Leu Xaa Leu His Pro Ser Ser Lys Ile 
                485                 490                 495     


Ala Lys Glu Asn Leu Asp Val Phe Cys Glu Ala Trp Glu Ser Gln Ile 
            500                 505                 510         


Ser Asp Met Ser Xaa Leu Leu Arg Glu Ile Asn Asp Val Phe Glu Gly 
        515                 520                 525             


Arg Arg Gly Glu Lys Tyr Gly Tyr Leu Ser Leu Pro Lys Pro Met Lys 
    530                 535                 540                 


Asn Asn Ala Asn Leu Lys Ser Leu Lys Pro Asp Lys Pro Asp Ser Glu 
545                 550                 555                 560 


Glu Gln Ala Lys Ile Ala Lys Leu Gly Leu Lys Leu Gly Leu Leu Xaa 
                565                 570                 575     


Ser Asp Ala Asp Cys Glu Ile Glu Lys Trp Glu Asp Gln Glu Asn Glu 
            580                 585                 590         


Ile Val Gln Tyr Gly Arg Asn Met Ser Ser Met Ala Tyr Ser Leu Tyr 
        595                 600                 605             


Leu Phe Xaa Arg Gly Glu Gly Pro Leu Lys Xaa Ser Gln Asp Leu Ile 
    610                 615                 620                 


His Gln Leu Glu Val Phe Ala Ala Glu Gly Leu Lys Leu Xaa Ser Ser 
625                 630                 635                 640 


Val Gln Ala Phe Ser Lys Gln Leu Lys Asp Asp Asp Lys Leu Met Leu 
                645                 650                 655     


Leu Leu Glu Ile Asn Lys Leu Ile Pro Leu Cys His Gln Leu Gln Xaa 
            660                 665                 670         


Val Xaa Lys Xaa Ser Leu Gln Asn Lys Val Phe Leu Lys Val Asp Lys 
        675                 680                 685             


Cys Ile Xaa Lys Xaa Arg Ser Met Met Ala Leu Leu Val Gln Leu Leu 
    690                 695                 700                 


Ser Leu Cys Tyr Lys Leu Leu Lys Lys Ser Glu Xaa Arg Tyr 
705                 710                 715             


<210> 7239
<211> 734
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (725)..(725)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<400> 7239
Met Ala Ala Ser Pro Gly Pro Ala Gly Val Gly Gly Ala Gly Ala Val 
1               5                   10                  15      


Tyr Gly Ser Gly Ser Ser Gly Phe Ala Leu Asp Ser Gly Leu Glu Ile 
            20                  25                  30          


Lys Xaa Arg Ser Val Glu Gln Xaa Leu Leu Pro Leu Val Ser Gln Ile 
        35                  40                  45              


Xaa Xaa Leu Ile Asn His Lys Asp Asn Xaa Lys Lys Ser Asp Lys Xaa 
    50                  55                  60                  


Leu Gln Ala Ile Gln Arg Val Gly Gln Ala Val Asn Leu Ala Val Gly 
65                  70                  75                  80  


Arg Phe Val Lys Val Gly Glu Ala Ile Ala Asn Glu Asn Trp Asp Leu 
                85                  90                  95      


Lys Glu Glu Ile Asn Ile Ala Cys Ile Glu Ala Lys Gln Ala Gly Glu 
            100                 105                 110         


Xaa Ile Ala Ala Leu Xaa Asp Ile Xaa Asn Leu Asn His Leu Glu Ser 
        115                 120                 125             


Asp Gly Gln Ile Xaa Ile Phe Xaa Asp Lys Xaa Gly Val Ile Lys Ala 
    130                 135                 140                 


Ala Arg Leu Leu Leu Ser Ser Val Xaa Lys Val Leu Leu Leu Ala Asp 
145                 150                 155                 160 


Arg Val Val Ile Lys Gln Ile Ile Xaa Ser Arg Asn Lys Val Leu Ala 
                165                 170                 175     


Xaa Met Glu Arg Leu Glu Lys Val Asn Ser Phe Gln Glu Phe Val Gln 
            180                 185                 190         


Ile Phe Ser Gln Phe Gly Asn Glu Met Val Glu Phe Ala His Leu Ser 
        195                 200                 205             


Gly Asp Arg Gln Asn Asp Leu Lys Asp Glu Lys Lys Lys Ala Lys Met 
    210                 215                 220                 


Ala Ala Ala Arg Ala Val Leu Glu Lys Cys Xaa Met Met Leu Leu Xaa 
225                 230                 235                 240 


Ala Ser Lys Xaa Cys Leu Arg His Pro Asn Cys Glu Ser Ala His Lys 
                245                 250                 255     


Asn Lys Glu Gly Val Phe Asp Arg Met Lys Val Ala Leu Asp Lys Val 
            260                 265                 270         


Ile Glu Ile Val Xaa Asp Cys Lys Pro Asn Gly Glu Xaa Asp Ile Ser 
        275                 280                 285             


Ser Ile Ser Ile Phe Xaa Gly Ile Lys Glu Phe Lys Met Asn Ile Glu 
    290                 295                 300                 


Ala Leu Arg Glu Asn Leu Tyr Phe Gln Ser Lys Glu Asn Leu Ser Val 
305                 310                 315                 320 


Xaa Leu Glu Val Ile Leu Glu Arg Met Glu Asp Phe Xaa Asp Ser Ala 
                325                 330                 335     


Tyr Xaa Ser His Glu His Arg Glu Arg Ile Leu Glu Leu Ser Xaa Gln 
            340                 345                 350         


Ala Arg Met Glu Leu Gln Gln Leu Ile Ser Val Trp Ile Gln Ala Gln 
        355                 360                 365             


Ser Lys Lys Xaa Lys Ser Ile Ala Glu Glu Leu Glu Leu Ser Ile Leu 
    370                 375                 380                 


Lys Ile Ser His Ser Leu Asn Glu Leu Lys Lys Glu Leu His Ser Xaa 
385                 390                 395                 400 


Ala Xaa Gln Leu Ala Ala Asp Leu Leu Lys Tyr His Ala Asp His Val 
                405                 410                 415     


Val Leu Lys Ala Leu Lys Leu Xaa Gly Val Glu Gly Asn Leu Glu Ala 
            420                 425                 430         


Leu Ala Glu Tyr Ala Cys Lys Leu Ser Glu Gln Lys Glu Gln Leu Val 
        435                 440                 445             


Glu Xaa Cys Arg Leu Leu Arg His Ile Ser Gly Xaa Glu Pro Leu Glu 
    450                 455                 460                 


Ile Xaa Cys Ile His Ala Glu Glu Xaa Phe Gln Val Xaa Gly Gln Gln 
465                 470                 475                 480 


Ile Ile Ser Ala Ala Glu Xaa Leu Xaa Leu His Pro Ser Ser Lys Ile 
                485                 490                 495     


Ala Lys Glu Asn Leu Asp Val Phe Cys Glu Ala Trp Glu Ser Gln Ile 
            500                 505                 510         


Ser Asp Met Ser Xaa Leu Leu Arg Glu Ile Asn Asp Val Phe Glu Gly 
        515                 520                 525             


Arg Arg Gly Glu Lys Tyr Gly Tyr Leu Ser Leu Pro Lys Pro Met Lys 
    530                 535                 540                 


Asn Asn Ala Asn Leu Lys Ser Leu Lys Pro Asp Lys Pro Asp Ser Glu 
545                 550                 555                 560 


Glu Gln Ala Lys Ile Ala Lys Leu Gly Leu Lys Leu Gly Leu Leu Xaa 
                565                 570                 575     


Ser Asp Ala Asp Cys Glu Ile Glu Lys Trp Glu Asp Gln Glu Asn Glu 
            580                 585                 590         


Ile Val Gln Tyr Gly Arg Asn Met Ser Ser Met Ala Tyr Ser Leu Tyr 
        595                 600                 605             


Leu Phe Xaa Arg Gly Glu Gly Pro Leu Lys Xaa Ser Gln Asp Leu Ile 
    610                 615                 620                 


His Gln Leu Glu Val Phe Ala Ala Glu Gly Leu Lys Leu Xaa Ser Ser 
625                 630                 635                 640 


Val Gln Ala Phe Ser Lys Gln Leu Lys Asp Asp Asp Lys Leu Met Leu 
                645                 650                 655     


Leu Leu Glu Ile Asn Lys Leu Ile Pro Leu Cys His Gln Leu Gln Xaa 
            660                 665                 670         


Val Xaa Lys Xaa Ser Leu Gln Asn Lys Val Phe Leu Lys Val Asp Lys 
        675                 680                 685             


Cys Ile Xaa Lys Xaa Arg Ser Met Met Ala Leu Leu Val Gln Leu Leu 
    690                 695                 700                 


Ser Leu Cys Tyr Lys Leu Leu Lys Lys Leu Gln Met Glu Asn Asn Gly 
705                 710                 715                 720 


Trp Val Ser Val Xaa Asn Lys Asp Xaa Met Asp Ser Lys Xaa 
                725                 730                 


<210> 7240
<211> 135
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<400> 7240
Met Ser Ser Met Ala Tyr Ser Leu Tyr Leu Phe Xaa Arg Gly Glu Gly 
1               5                   10                  15      


Pro Leu Lys Xaa Ser Gln Asp Leu Ile His Gln Leu Glu Val Phe Ala 
            20                  25                  30          


Ala Glu Gly Leu Lys Leu Xaa Ser Ser Val Gln Ala Phe Ser Lys Gln 
        35                  40                  45              


Leu Lys Asp Asp Asp Lys Leu Met Leu Leu Leu Glu Ile Asn Lys Leu 
    50                  55                  60                  


Ile Pro Leu Cys His Gln Leu Gln Xaa Val Xaa Lys Xaa Ser Leu Gln 
65                  70                  75                  80  


Asn Lys Val Phe Leu Lys Val Asp Lys Cys Ile Xaa Lys Xaa Arg Ser 
                85                  90                  95      


Met Met Ala Leu Leu Val Gln Leu Leu Ser Leu Cys Tyr Lys Leu Leu 
            100                 105                 110         


Lys Lys Leu Gln Met Glu Asn Asn Gly Trp Val Ser Val Xaa Asn Lys 
        115                 120                 125             


Asp Xaa Met Asp Ser Lys Xaa 
    130                 135 


<210> 7241
<211> 13
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<400> 7241
Met Ala Xaa Gln Ala Asp Leu Met Glu Leu Asp Met Ala 
1               5                   10              


<210> 7242
<211> 100
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<400> 7242
Met Ala Xaa Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 
1               5                   10                  15      


Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 
            20                  25                  30          


Ser Gly Ile His Ser Gly Ala Xaa Xaa Xaa Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Xaa Ser Gln Val Leu Tyr 
    50                  55                  60                  


Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Xaa Gln Glu Gln Val Ala 
65                  70                  75                  80  


Asp Ile Asp Gly Gln Tyr Ala Met Xaa Arg Ala Gln Arg Val Arg Ala 
                85                  90                  95      


Ala Met Phe Pro 
            100 


<210> 7243
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<400> 7243
Met Ala Xaa Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 
1               5                   10                  15      


Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 
            20                  25                  30          


Ser Gly Ile His Ser Gly Ala Xaa Xaa Xaa Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Xaa Ser Gln Val Leu Tyr 
    50                  55                  60                  


Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Xaa Gln Glu Gln Val Ala 
65                  70                  75                  80  


Asp Ile Asp Gly Gln Tyr Ala Met Xaa Arg Ala Gln Arg Val Arg Ala 
                85                  90                  95      


Ala Met Phe Pro Glu Xaa Leu Asp Glu Gly Met Gln 
            100                 105             


<210> 7244
<211> 150
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<400> 7244
Met Ala Xaa Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 
1               5                   10                  15      


Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 
            20                  25                  30          


Ser Gly Ile His Ser Gly Ala Xaa Xaa Xaa Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Xaa Ser Gln Val Leu Tyr 
    50                  55                  60                  


Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Xaa Gln Glu Gln Val Ala 
65                  70                  75                  80  


Asp Ile Asp Gly Gln Tyr Ala Met Xaa Arg Ala Gln Arg Val Arg Ala 
                85                  90                  95      


Ala Met Phe Pro Glu Xaa Leu Asp Glu Gly Met Gln Ile Pro Ser Xaa 
            100                 105                 110         


Gln Phe Asp Ala Ala His Pro Xaa Asn Val Gln Arg Leu Ala Glu Pro 
        115                 120                 125             


Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 
    130                 135                 140                 


Asp Ala Glu Leu Ala Xaa 
145                 150 


<210> 7245
<211> 781
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (641)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (685)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<400> 7245
Met Ala Xaa Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 
1               5                   10                  15      


Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 
            20                  25                  30          


Ser Gly Ile His Ser Gly Ala Xaa Xaa Xaa Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Xaa Ser Gln Val Leu Tyr 
    50                  55                  60                  


Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Xaa Gln Glu Gln Val Ala 
65                  70                  75                  80  


Asp Ile Asp Gly Gln Tyr Ala Met Xaa Arg Ala Gln Arg Val Arg Ala 
                85                  90                  95      


Ala Met Phe Pro Glu Xaa Leu Asp Glu Gly Met Gln Ile Pro Ser Xaa 
            100                 105                 110         


Gln Phe Asp Ala Ala His Pro Xaa Asn Val Gln Arg Leu Ala Glu Pro 
        115                 120                 125             


Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 
    130                 135                 140                 


Asp Ala Glu Leu Ala Xaa Arg Ala Ile Pro Glu Leu Xaa Lys Leu Leu 
145                 150                 155                 160 


Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His 
                165                 170                 175     


Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro 
            180                 185                 190         


Gln Met Val Ser Ala Ile Val Arg Xaa Met Gln Asn Xaa Asn Asp Val 
        195                 200                 205             


Glu Xaa Ala Arg Cys Xaa Ala Gly Xaa Leu His Asn Leu Ser His His 
    210                 215                 220                 


Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu 
225                 230                 235                 240 


Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile 
                245                 250                 255     


Xaa Xaa Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala 
            260                 265                 270         


Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys 
        275                 280                 285             


Xaa Asn Val Lys Phe Leu Ala Ile Xaa Xaa Asp Cys Leu Gln Ile Leu 
    290                 295                 300                 


Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly 
305                 310                 315                 320 


Pro Gln Ala Leu Val Asn Ile Met Arg Xaa Tyr Xaa Tyr Glu Lys Leu 
                325                 330                 335     


Leu Trp Xaa Xaa Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser 
            340                 345                 350         


Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu 
        355                 360                 365             


His Leu Xaa Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Xaa 
    370                 375                 380                 


Leu Arg Asn Leu Ser Asp Ala Ala Xaa Lys Gln Glu Gly Met Glu Gly 
385                 390                 395                 400 


Leu Leu Gly Xaa Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val 
                405                 410                 415     


Val Xaa Cys Ala Ala Gly Ile Leu Ser Asn Leu Xaa Cys Asn Asn Tyr 
            420                 425                 430         


Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val 
        435                 440                 445             


Arg Xaa Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Xaa Glu Pro Ala 
    450                 455                 460                 


Ile Cys Ala Leu Arg His Leu Xaa Ser Arg His Gln Glu Ala Glu Met 
465                 470                 475                 480 


Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys 
                485                 490                 495     


Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Xaa Val Gly 
            500                 505                 510         


Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg 
        515                 520                 525             


Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His 
    530                 535                 540                 


Gln Asp Xaa Gln Arg Arg Xaa Ser Met Gly Gly Xaa Gln Gln Gln Phe 
545                 550                 555                 560 


Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Xaa Gly Ala 
                565                 570                 575     


Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly 
            580                 585                 590         


Leu Asn Xaa Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu 
        595                 600                 605             


Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp 
    610                 615                 620                 


Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Xaa Ala Pro Leu 
625                 630                 635                 640 


Xaa Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Xaa Tyr Ala Ala 
                645                 650                 655     


Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys 
            660                 665                 670         


Arg Leu Ser Val Glu Leu Xaa Ser Ser Leu Phe Arg Xaa Glu Pro Met 
        675                 680                 685             


Ala Trp Asn Glu Xaa Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly 
    690                 695                 700                 


Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His 
705                 710                 715                 720 


Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu 
                725                 730                 735     


His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly 
            740                 745                 750         


Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro 
        755                 760                 765             


Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Xaa Asp Leu 
    770                 775                 780     


<210> 7246
<211> 59
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 7246
Met Glu Leu Asp Met Ala Met Glu Pro Asp Arg Lys Ala Ala Val Ser 
1               5                   10                  15      


His Trp Gln Gln Gln Ser Tyr Leu Asp Ser Gly Ile His Ser Gly Ala 
            20                  25                  30          


Xaa Xaa Xaa Ala Pro Ser Leu Ser Gly Lys Gly Asn Pro Glu Glu Glu 
        35                  40                  45              


Asp Val Asp Xaa Ser Gln Val Leu Tyr Glu Trp 
    50                  55                  


<210> 7247
<211> 774
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<400> 7247
Met Glu Leu Asp Met Ala Met Glu Pro Asp Arg Lys Ala Ala Val Ser 
1               5                   10                  15      


His Trp Gln Gln Gln Ser Tyr Leu Asp Ser Gly Ile His Ser Gly Ala 
            20                  25                  30          


Xaa Xaa Xaa Ala Pro Ser Leu Ser Gly Lys Gly Asn Pro Glu Glu Glu 
        35                  40                  45              


Asp Val Asp Xaa Ser Gln Val Leu Tyr Glu Trp Glu Gln Gly Phe Ser 
    50                  55                  60                  


Gln Ser Phe Xaa Gln Glu Gln Val Ala Asp Ile Asp Gly Gln Tyr Ala 
65                  70                  75                  80  


Met Xaa Arg Ala Gln Arg Val Arg Ala Ala Met Phe Pro Glu Xaa Leu 
                85                  90                  95      


Asp Glu Gly Met Gln Ile Pro Ser Xaa Gln Phe Asp Ala Ala His Pro 
            100                 105                 110         


Xaa Asn Val Gln Arg Leu Ala Glu Pro Ser Gln Met Leu Lys His Ala 
        115                 120                 125             


Val Val Asn Leu Ile Asn Tyr Gln Asp Asp Ala Glu Leu Ala Xaa Arg 
    130                 135                 140                 


Ala Ile Pro Glu Leu Xaa Lys Leu Leu Asn Asp Glu Asp Gln Val Val 
145                 150                 155                 160 


Val Asn Lys Ala Ala Val Met Val His Gln Leu Ser Lys Lys Glu Ala 
                165                 170                 175     


Ser Arg His Ala Ile Met Arg Ser Pro Gln Met Val Ser Ala Ile Val 
            180                 185                 190         


Arg Xaa Met Gln Asn Xaa Asn Asp Val Glu Xaa Ala Arg Cys Xaa Ala 
        195                 200                 205             


Gly Xaa Leu His Asn Leu Ser His His Arg Glu Gly Leu Leu Ala Ile 
    210                 215                 220                 


Phe Lys Ser Gly Gly Ile Pro Ala Leu Val Lys Met Leu Gly Ser Pro 
225                 230                 235                 240 


Val Asp Ser Val Leu Phe Tyr Ala Ile Xaa Xaa Leu His Asn Leu Leu 
                245                 250                 255     


Leu His Gln Glu Gly Ala Lys Met Ala Val Arg Leu Ala Gly Gly Leu 
            260                 265                 270         


Gln Lys Met Val Ala Leu Leu Asn Lys Xaa Asn Val Lys Phe Leu Ala 
        275                 280                 285             


Ile Xaa Xaa Asp Cys Leu Gln Ile Leu Ala Tyr Gly Asn Gln Glu Ser 
    290                 295                 300                 


Lys Leu Ile Ile Leu Ala Ser Gly Gly Pro Gln Ala Leu Val Asn Ile 
305                 310                 315                 320 


Met Arg Xaa Tyr Xaa Tyr Glu Lys Leu Leu Trp Xaa Xaa Ser Arg Val 
                325                 330                 335     


Leu Lys Val Leu Ser Val Cys Ser Ser Asn Lys Pro Ala Ile Val Glu 
            340                 345                 350         


Ala Gly Gly Met Gln Ala Leu Gly Leu His Leu Xaa Asp Pro Ser Gln 
        355                 360                 365             


Arg Leu Val Gln Asn Cys Leu Trp Xaa Leu Arg Asn Leu Ser Asp Ala 
    370                 375                 380                 


Ala Xaa Lys Gln Glu Gly Met Glu Gly Leu Leu Gly Xaa Leu Val Gln 
385                 390                 395                 400 


Leu Leu Gly Ser Asp Asp Ile Asn Val Val Xaa Cys Ala Ala Gly Ile 
                405                 410                 415     


Leu Ser Asn Leu Xaa Cys Asn Asn Tyr Lys Asn Lys Met Met Val Cys 
            420                 425                 430         


Gln Val Gly Gly Ile Glu Ala Leu Val Arg Xaa Val Leu Arg Ala Gly 
        435                 440                 445             


Asp Arg Glu Asp Ile Xaa Glu Pro Ala Ile Cys Ala Leu Arg His Leu 
    450                 455                 460                 


Xaa Ser Arg His Gln Glu Ala Glu Met Ala Gln Asn Ala Val Arg Leu 
465                 470                 475                 480 


His Tyr Gly Leu Pro Val Val Val Lys Leu Leu His Pro Pro Ser His 
                485                 490                 495     


Trp Pro Leu Ile Lys Ala Xaa Val Gly Leu Ile Arg Asn Leu Ala Leu 
            500                 505                 510         


Cys Pro Ala Asn His Ala Pro Leu Arg Glu Gln Gly Ala Ile Pro Arg 
        515                 520                 525             


Leu Val Gln Leu Leu Val Arg Ala His Gln Asp Xaa Gln Arg Arg Xaa 
    530                 535                 540                 


Ser Met Gly Gly Xaa Gln Gln Gln Phe Val Glu Gly Val Arg Met Glu 
545                 550                 555                 560 


Glu Ile Val Glu Gly Cys Xaa Gly Ala Leu His Ile Leu Ala Arg Asp 
                565                 570                 575     


Val His Asn Arg Ile Val Ile Arg Gly Leu Asn Xaa Ile Pro Leu Phe 
            580                 585                 590         


Val Gln Leu Leu Tyr Ser Pro Ile Glu Asn Ile Gln Arg Val Ala Ala 
        595                 600                 605             


Gly Val Leu Cys Glu Leu Ala Gln Asp Lys Glu Ala Ala Glu Ala Ile 
    610                 615                 620                 


Glu Ala Glu Gly Ala Xaa Ala Pro Leu Xaa Glu Leu Leu His Ser Arg 
625                 630                 635                 640 


Asn Glu Gly Val Ala Xaa Tyr Ala Ala Ala Val Leu Phe Arg Met Ser 
                645                 650                 655     


Glu Asp Lys Pro Gln Asp Tyr Lys Lys Arg Leu Ser Val Glu Leu Xaa 
            660                 665                 670         


Ser Ser Leu Phe Arg Xaa Glu Pro Met Ala Trp Asn Glu Xaa Ala Asp 
        675                 680                 685             


Leu Gly Leu Asp Ile Gly Ala Gln Gly Glu Pro Leu Gly Tyr Arg Gln 
    690                 695                 700                 


Asp Asp Pro Ser Tyr Arg Ser Phe His Ser Gly Gly Tyr Gly Gln Asp 
705                 710                 715                 720 


Ala Leu Gly Met Asp Pro Met Met Glu His Glu Met Gly Gly His His 
                725                 730                 735     


Pro Gly Ala Asp Tyr Pro Val Asp Gly Leu Pro Asp Leu Gly His Ala 
            740                 745                 750         


Gln Asp Leu Met Asp Gly Leu Pro Pro Gly Asp Ser Asn Gln Leu Ala 
        755                 760                 765             


Trp Phe Asp Xaa Asp Leu 
    770                 


<210> 7248
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<400> 7248
Met Asn Arg Glu Gly Ala Pro Gly Lys Ser Pro Glu Glu Met Tyr Ile 
1               5                   10                  15      


Gln Gln Lys Val Arg Val Leu Leu Met Leu Arg Lys Met Gly Ser Asn 
            20                  25                  30          


Leu Xaa Ala Ser Glu Glu Glu Phe Leu Arg Xaa Tyr Ala Gly Val Val 
        35                  40                  45              


Asn Ser Gln Leu Ser Gln Leu Pro Pro His Ser Ile Asp Gln Gly Ala 
    50                  55                  60                  


Glu Asp Val Val Met Ala Phe Ser Arg Ser Glu Xaa Glu Asp Arg Arg 
65                  70                  75                  80  


Gln 
    


<210> 7249
<211> 261
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<400> 7249
Met Ala Asn Gly Xaa Leu Xaa Arg Arg His Gln Asp His Ser His Leu 
1               5                   10                  15      


Leu Tyr Ser Xaa Ile Pro Arg Met Gln Glu Pro Gly Gln Ile Val Glu 
            20                  25                  30          


Xaa Tyr Xaa Glu Glu Asp Pro Glu Gly Ala Met Ser Val Val Ser Val 
        35                  40                  45              


Glu Xaa Ser Asp Asp Gly Xaa Xaa Arg Arg Xaa Glu Xaa Xaa Val Lys 
    50                  55                  60                  


Lys Val Val Lys Xaa Val Xaa Xaa Arg Xaa Val Gln Pro Val Ala Met 
65                  70                  75                  80  


Gly Pro Asp Gly Leu Pro Val Asp Ala Ser Ser Val Ser Asn Asn Tyr 
                85                  90                  95      


Ile Gln Xaa Leu Gly Arg Asp Phe Arg Lys Asn Gly Asn Gly Gly Pro 
            100                 105                 110         


Gly Pro Tyr Val Gly Gln Ala Gly Xaa Ala Xaa Leu Pro Arg Asn Phe 
        115                 120                 125             


His Tyr Pro Pro Asp Gly Tyr Ser Arg His Tyr Glu Asp Gly Tyr Pro 
    130                 135                 140                 


Gly Gly Ser Asp Asn Tyr Gly Ser Leu Ser Arg Val Xaa Arg Ile Glu 
145                 150                 155                 160 


Glu Arg Tyr Arg Pro Ser Met Glu Gly Tyr Arg Ala Pro Ser Arg Gln 
                165                 170                 175     


Asp Val Tyr Gly Pro Gln Pro Gln Val Arg Val Gly Gly Ser Ser Val 
            180                 185                 190         


Asp Leu His Arg Phe His Pro Glu Pro Tyr Gly Leu Glu Asp Asp Gln 
        195                 200                 205             


Arg Ser Met Gly Tyr Asp Asp Leu Asp Tyr Gly Met Met Ser Asp Tyr 
    210                 215                 220                 


Gly Xaa Ala Arg Arg Xaa Gly Xaa Pro Ser Asp Pro Arg Arg Arg Leu 
225                 230                 235                 240 


Arg Ser Tyr Glu Asp Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr 
                245                 250                 255     


Tyr Trp Ala Pro Leu 
            260     


<210> 7250
<211> 129
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<400> 7250
Met Ala Asn Gly Xaa Leu Xaa Arg Arg His Gln Asn Gly Arg Phe Val 
1               5                   10                  15      


Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe Ser Asp Leu Lys Leu Asn 
            20                  25                  30          


Gly Pro Gln Asp His Ser His Leu Leu Tyr Ser Xaa Ile Pro Arg Met 
        35                  40                  45              


Gln Glu Pro Gly Gln Ile Val Glu Xaa Tyr Xaa Glu Glu Asp Pro Glu 
    50                  55                  60                  


Gly Ala Met Ser Val Val Ser Val Glu Xaa Ser Asp Asp Gly Xaa Xaa 
65                  70                  75                  80  


Arg Arg Xaa Glu Xaa Xaa Val Lys Lys Val Val Lys Xaa Val Xaa Xaa 
                85                  90                  95      


Arg Xaa Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val Asp 
            100                 105                 110         


Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Xaa Leu Gly Arg Asp Phe 
        115                 120                 125             


Arg 
    


<210> 7251
<211> 879
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(873)
<223> Selenocysteine

<400> 7251
Met Ala Asn Gly Xaa Leu Xaa Arg Arg His Gln Asn Gly Arg Phe Val 
1               5                   10                  15      


Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe Ser Asp Leu Lys Leu Asn 
            20                  25                  30          


Gly Pro Gln Asp His Ser His Leu Leu Tyr Ser Xaa Ile Pro Arg Met 
        35                  40                  45              


Gln Glu Pro Gly Gln Ile Val Glu Xaa Tyr Xaa Glu Glu Asp Pro Glu 
    50                  55                  60                  


Gly Ala Met Ser Val Val Ser Val Glu Xaa Ser Asp Asp Gly Xaa Xaa 
65                  70                  75                  80  


Arg Arg Xaa Glu Xaa Xaa Val Lys Lys Val Val Lys Xaa Val Xaa Xaa 
                85                  90                  95      


Arg Xaa Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val Asp 
            100                 105                 110         


Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Xaa Leu Gly Arg Asp Phe 
        115                 120                 125             


Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala Gly 
    130                 135                 140                 


Xaa Ala Xaa Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr Ser 
145                 150                 155                 160 


Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly Ser 
                165                 170                 175     


Leu Ser Arg Val Xaa Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met Glu 
            180                 185                 190         


Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro Gln 
        195                 200                 205             


Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro Glu 
    210                 215                 220                 


Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp Leu 
225                 230                 235                 240 


Asp Tyr Gly Met Met Ser Asp Tyr Gly Xaa Ala Arg Arg Xaa Gly Xaa 
                245                 250                 255     


Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile Gly 
            260                 265                 270         


Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln His 
        275                 280                 285             


Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly Pro 
    290                 295                 300                 


Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala Met 
305                 310                 315                 320 


Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr Leu 
                325                 330                 335     


Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Xaa Asp Val Arg Lys 
            340                 345                 350         


Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys Lys 
        355                 360                 365             


Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe Gly 
    370                 375                 380                 


Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val Pro 
385                 390                 395                 400 


Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Xaa Glu 
                405                 410                 415     


Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser Ser His Asp Ser Ile Lys 
            420                 425                 430         


Met Glu Ile Val Asp His Ala Leu His Ala Leu Xaa Asp Glu Val Ile 
        435                 440                 445             


Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys Pro 
    450                 455                 460                 


Arg His Ile Glu Trp Glu Ser Val Leu Xaa Asn Xaa Ala Gly Cys Leu 
465                 470                 475                 480 


Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg Glu 
                485                 490                 495     


Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu Ile 
            500                 505                 510         


Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys Leu 
        515                 520                 525             


Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala Glu 
    530                 535                 540                 


Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Xaa Gly Pro His 
545                 550                 555                 560 


Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys Lys Pro Ile 
                565                 570                 575     


Glu Asp Pro Ala Asn Asp Xaa Val Asp Phe Pro Lys Arg Xaa Ser Pro 
            580                 585                 590         


Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile Tyr 
        595                 600                 605             


Ile Ser Leu Leu Lys Glu Ser Lys Xaa Pro Ala Ile Leu Glu Ala Ser 
    610                 615                 620                 


Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Xaa Tyr Gly Arg 
625                 630                 635                 640 


Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile Ala 
                645                 650                 655     


Asp Leu Leu Xaa Asn Glu His Glu Arg Val Val Lys Ala Ala Ser Gly 
            660                 665                 670         


Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile Gly 
        675                 680                 685             


Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln Gln 
    690                 695                 700                 


Asn Ser Ser Trp Asn Phe Ser Glu Asp Xaa Val Ile Ser Ile Leu Asn 
705                 710                 715                 720 


Xaa Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys Leu 
                725                 730                 735     


Arg Glu Xaa Gln Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser Gly 
            740                 745                 750         


Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln Xaa 
        755                 760                 765             


Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly Trp 
    770                 775                 780                 


Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser Gln 
785                 790                 795                 800 


Ser Ser His Ser Tyr Asp Asp Ser Xaa Leu Pro Leu Ile Asp Arg Asn 
                805                 810                 815     


Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu Glu Ile Gln Met Ser Asn 
            820                 825                 830         


Met Gly Ser Asn Xaa Lys Ser Leu Asp Asn Asn Tyr Ser Xaa Pro Asn 
        835                 840                 845             


Glu Arg Gly Asp His Asn Arg Xaa Leu Asp Arg Ser Gly Asp Leu Gly 
    850                 855                 860                 


Asp Met Glu Pro Leu Lys Gly Xaa Xaa Pro Leu Met Gln Lys Ile 
865                 870                 875                 


<210> 7252
<211> 885
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(879)
<223> Selenocysteine

<400> 7252
Met Ala Asn Gly Xaa Leu Xaa Arg Arg His Gln Asn Gly Arg Phe Val 
1               5                   10                  15      


Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe Ser Asp Leu Lys Leu Asn 
            20                  25                  30          


Gly Pro Gln Asp His Ser His Leu Leu Tyr Ser Xaa Ile Pro Arg Met 
        35                  40                  45              


Gln Glu Pro Gly Gln Ile Val Glu Xaa Tyr Xaa Glu Glu Asp Pro Glu 
    50                  55                  60                  


Gly Ala Met Ser Val Val Ser Val Glu Xaa Ser Asp Asp Gly Xaa Xaa 
65                  70                  75                  80  


Arg Arg Xaa Glu Xaa Xaa Val Lys Lys Val Val Lys Xaa Val Xaa Xaa 
                85                  90                  95      


Arg Xaa Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val Asp 
            100                 105                 110         


Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Xaa Leu Gly Arg Asp Phe 
        115                 120                 125             


Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala Gly 
    130                 135                 140                 


Xaa Ala Xaa Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr Ser 
145                 150                 155                 160 


Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly Ser 
                165                 170                 175     


Leu Ser Arg Val Xaa Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met Glu 
            180                 185                 190         


Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro Gln 
        195                 200                 205             


Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro Glu 
    210                 215                 220                 


Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp Leu 
225                 230                 235                 240 


Asp Tyr Gly Met Met Ser Asp Tyr Gly Xaa Ala Arg Arg Xaa Gly Xaa 
                245                 250                 255     


Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile Gly 
            260                 265                 270         


Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln His 
        275                 280                 285             


Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly Pro 
    290                 295                 300                 


Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala Met 
305                 310                 315                 320 


Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr Leu 
                325                 330                 335     


Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Xaa Asp Val Arg Lys 
            340                 345                 350         


Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys Lys 
        355                 360                 365             


Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe Gly 
    370                 375                 380                 


Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val Pro 
385                 390                 395                 400 


Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Xaa Glu 
                405                 410                 415     


Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser Ser His Asp Ser Ile Lys 
            420                 425                 430         


Met Glu Ile Val Asp His Ala Leu His Ala Leu Xaa Asp Glu Val Ile 
        435                 440                 445             


Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys Pro 
    450                 455                 460                 


Arg His Ile Glu Trp Glu Ser Val Leu Xaa Asn Xaa Ala Gly Cys Leu 
465                 470                 475                 480 


Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg Glu 
                485                 490                 495     


Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu Ile 
            500                 505                 510         


Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys Leu 
        515                 520                 525             


Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala Glu 
    530                 535                 540                 


Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Xaa Gly Pro His 
545                 550                 555                 560 


Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Asp Glu Trp Phe Ser 
                565                 570                 575     


Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Xaa Val Asp Phe 
            580                 585                 590         


Pro Lys Arg Xaa Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro 
        595                 600                 605             


Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Xaa Pro 
    610                 615                 620                 


Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly 
625                 630                 635                 640 


Arg Trp Xaa Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys 
                645                 650                 655     


Ala Leu Ser Ala Ile Ala Asp Leu Leu Xaa Asn Glu His Glu Arg Val 
            660                 665                 670         


Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg 
        675                 680                 685             


Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn 
    690                 695                 700                 


Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Xaa 
705                 710                 715                 720 


Val Ile Ser Ile Leu Asn Xaa Ile Asn Glu Val Ile Ala Glu Asn Leu 
                725                 730                 735     


Glu Ala Ala Lys Lys Leu Arg Glu Xaa Gln Gly Ile Glu Lys Leu Val 
            740                 745                 750         


Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala 
        755                 760                 765             


Ala Leu Val Leu Gln Xaa Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro 
    770                 775                 780                 


Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn 
785                 790                 795                 800 


Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Xaa Leu 
                805                 810                 815     


Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu 
            820                 825                 830         


Glu Ile Gln Met Ser Asn Met Gly Ser Asn Xaa Lys Ser Leu Asp Asn 
        835                 840                 845             


Asn Tyr Ser Xaa Pro Asn Glu Arg Gly Asp His Asn Arg Xaa Leu Asp 
    850                 855                 860                 


Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Xaa Xaa Pro 
865                 870                 875                 880 


Leu Met Gln Lys Ile 
                885 


<210> 7253
<211> 887
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(852)
<223> Selenocysteine

<400> 7253
Met Ala Asn Gly Xaa Leu Xaa Arg Arg His Gln Asn Gly Arg Phe Val 
1               5                   10                  15      


Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe Ser Asp Leu Lys Leu Asn 
            20                  25                  30          


Gly Pro Gln Asp His Ser His Leu Leu Tyr Ser Xaa Ile Pro Arg Met 
        35                  40                  45              


Gln Glu Pro Gly Gln Ile Val Glu Xaa Tyr Xaa Glu Glu Asp Pro Glu 
    50                  55                  60                  


Gly Ala Met Ser Val Val Ser Val Glu Xaa Ser Asp Asp Gly Xaa Xaa 
65                  70                  75                  80  


Arg Arg Xaa Glu Xaa Xaa Val Lys Lys Val Val Lys Xaa Val Xaa Xaa 
                85                  90                  95      


Arg Xaa Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val Asp 
            100                 105                 110         


Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Xaa Leu Gly Arg Asp Phe 
        115                 120                 125             


Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala Gly 
    130                 135                 140                 


Xaa Ala Xaa Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr Ser 
145                 150                 155                 160 


Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly Ser 
                165                 170                 175     


Leu Ser Arg Val Xaa Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met Glu 
            180                 185                 190         


Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro Gln 
        195                 200                 205             


Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro Glu 
    210                 215                 220                 


Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp Leu 
225                 230                 235                 240 


Asp Tyr Gly Met Met Ser Asp Tyr Gly Xaa Ala Arg Arg Xaa Gly Xaa 
                245                 250                 255     


Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile Gly 
            260                 265                 270         


Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln His 
        275                 280                 285             


Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly Pro 
    290                 295                 300                 


Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala Met 
305                 310                 315                 320 


Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr Leu 
                325                 330                 335     


Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Xaa Asp Val Arg Lys 
            340                 345                 350         


Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys Lys 
        355                 360                 365             


Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe Gly 
    370                 375                 380                 


Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val Pro 
385                 390                 395                 400 


Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Xaa Glu 
                405                 410                 415     


Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser Ser His Asp Ser Ile Lys 
            420                 425                 430         


Met Glu Ile Val Asp His Ala Leu His Ala Leu Xaa Asp Glu Val Ile 
        435                 440                 445             


Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys Pro 
    450                 455                 460                 


Arg His Ile Glu Trp Glu Ser Val Leu Xaa Asn Xaa Ala Gly Cys Leu 
465                 470                 475                 480 


Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg Glu 
                485                 490                 495     


Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu Ile 
            500                 505                 510         


Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys Leu 
        515                 520                 525             


Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala Glu 
    530                 535                 540                 


Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Xaa Gly Pro His 
545                 550                 555                 560 


Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys Lys Pro Ile 
                565                 570                 575     


Glu Asp Pro Ala Asn Asp Xaa Val Asp Phe Pro Lys Arg Xaa Ser Pro 
            580                 585                 590         


Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile Tyr 
        595                 600                 605             


Ile Ser Leu Leu Lys Glu Ser Lys Xaa Pro Ala Ile Leu Glu Ala Ser 
    610                 615                 620                 


Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Xaa Tyr Gly Arg 
625                 630                 635                 640 


Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile Ala 
                645                 650                 655     


Asp Leu Leu Xaa Asn Glu His Glu Arg Val Val Lys Ala Ala Ser Gly 
            660                 665                 670         


Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile Gly 
        675                 680                 685             


Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln Gln 
    690                 695                 700                 


Asn Ser Ser Trp Asn Phe Ser Glu Asp Xaa Val Ile Ser Ile Leu Asn 
705                 710                 715                 720 


Xaa Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys Leu 
                725                 730                 735     


Arg Glu Xaa Gln Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser Gly 
            740                 745                 750         


Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln Xaa 
        755                 760                 765             


Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly Trp 
    770                 775                 780                 


Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser Gln 
785                 790                 795                 800 


Ser Ser His Ser Tyr Asp Asp Ser Xaa Leu Pro Leu Ile Asp Arg Asn 
                805                 810                 815     


Gln Lys Ser Asp Asn Asn Tyr Ser Xaa Pro Asn Glu Arg Gly Asp His 
            820                 825                 830         


Asn Arg Xaa Leu Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu 
        835                 840                 845             


Lys Gly Xaa Xaa Pro Leu Met Gln Asp Glu Gly Gln Glu Ser Leu Glu 
    850                 855                 860                 


Glu Glu Leu Asp Val Leu Val Leu Asp Asp Glu Gly Gly Gln Val Ser 
865                 870                 875                 880 


Tyr Pro Ser Met Gln Lys Ile 
                885         


<210> 7254
<211> 908
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (837)..(837)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (856)..(856)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(873)
<223> Selenocysteine

<400> 7254
Met Ala Asn Gly Xaa Leu Xaa Arg Arg His Gln Asn Gly Arg Phe Val 
1               5                   10                  15      


Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe Ser Asp Leu Lys Leu Asn 
            20                  25                  30          


Gly Pro Gln Asp His Ser His Leu Leu Tyr Ser Xaa Ile Pro Arg Met 
        35                  40                  45              


Gln Glu Pro Gly Gln Ile Val Glu Xaa Tyr Xaa Glu Glu Asp Pro Glu 
    50                  55                  60                  


Gly Ala Met Ser Val Val Ser Val Glu Xaa Ser Asp Asp Gly Xaa Xaa 
65                  70                  75                  80  


Arg Arg Xaa Glu Xaa Xaa Val Lys Lys Val Val Lys Xaa Val Xaa Xaa 
                85                  90                  95      


Arg Xaa Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val Asp 
            100                 105                 110         


Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Xaa Leu Gly Arg Asp Phe 
        115                 120                 125             


Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala Gly 
    130                 135                 140                 


Xaa Ala Xaa Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr Ser 
145                 150                 155                 160 


Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly Ser 
                165                 170                 175     


Leu Ser Arg Val Xaa Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met Glu 
            180                 185                 190         


Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro Gln 
        195                 200                 205             


Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro Glu 
    210                 215                 220                 


Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp Leu 
225                 230                 235                 240 


Asp Tyr Gly Met Met Ser Asp Tyr Gly Xaa Ala Arg Arg Xaa Gly Xaa 
                245                 250                 255     


Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile Gly 
            260                 265                 270         


Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln His 
        275                 280                 285             


Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly Pro 
    290                 295                 300                 


Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala Met 
305                 310                 315                 320 


Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr Leu 
                325                 330                 335     


Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Xaa Asp Val Arg Lys 
            340                 345                 350         


Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys Lys 
        355                 360                 365             


Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe Gly 
    370                 375                 380                 


Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val Pro 
385                 390                 395                 400 


Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Xaa Glu 
                405                 410                 415     


Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser Ser His Asp Ser Ile Lys 
            420                 425                 430         


Met Glu Ile Val Asp His Ala Leu His Ala Leu Xaa Asp Glu Val Ile 
        435                 440                 445             


Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys Pro 
    450                 455                 460                 


Arg His Ile Glu Trp Glu Ser Val Leu Xaa Asn Xaa Ala Gly Cys Leu 
465                 470                 475                 480 


Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg Glu 
                485                 490                 495     


Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu Ile 
            500                 505                 510         


Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys Leu 
        515                 520                 525             


Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala Glu 
    530                 535                 540                 


Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Xaa Gly Pro His 
545                 550                 555                 560 


Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys Lys Pro Ile 
                565                 570                 575     


Glu Asp Pro Ala Asn Asp Xaa Val Asp Phe Pro Lys Arg Xaa Ser Pro 
            580                 585                 590         


Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile Tyr 
        595                 600                 605             


Ile Ser Leu Leu Lys Glu Ser Lys Xaa Pro Ala Ile Leu Glu Ala Ser 
    610                 615                 620                 


Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Xaa Tyr Gly Arg 
625                 630                 635                 640 


Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile Ala 
                645                 650                 655     


Asp Leu Leu Xaa Asn Glu His Glu Arg Val Val Lys Ala Ala Ser Gly 
            660                 665                 670         


Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile Gly 
        675                 680                 685             


Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln Gln 
    690                 695                 700                 


Asn Ser Ser Trp Asn Phe Ser Glu Asp Xaa Val Ile Ser Ile Leu Asn 
705                 710                 715                 720 


Xaa Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys Leu 
                725                 730                 735     


Arg Glu Xaa Gln Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser Gly 
            740                 745                 750         


Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln Xaa 
        755                 760                 765             


Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly Trp 
    770                 775                 780                 


Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser Gln 
785                 790                 795                 800 


Ser Ser His Ser Tyr Asp Asp Ser Xaa Leu Pro Leu Ile Asp Arg Asn 
                805                 810                 815     


Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu Glu Ile Gln Met Ser Asn 
            820                 825                 830         


Met Gly Ser Asn Xaa Lys Ser Leu Asp Asn Asn Tyr Ser Xaa Pro Asn 
        835                 840                 845             


Glu Arg Gly Asp His Asn Arg Xaa Leu Asp Arg Ser Gly Asp Leu Gly 
    850                 855                 860                 


Asp Met Glu Pro Leu Lys Gly Xaa Xaa Pro Leu Met Gln Asp Glu Gly 
865                 870                 875                 880 


Gln Glu Ser Leu Glu Glu Glu Leu Asp Val Leu Val Leu Asp Asp Glu 
                885                 890                 895     


Gly Gly Gln Val Ser Tyr Pro Ser Met Gln Lys Ile 
            900                 905             


<210> 7255
<211> 914
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(879)
<223> Selenocysteine

<400> 7255
Met Ala Asn Gly Xaa Leu Xaa Arg Arg His Gln Asn Gly Arg Phe Val 
1               5                   10                  15      


Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe Ser Asp Leu Lys Leu Asn 
            20                  25                  30          


Gly Pro Gln Asp His Ser His Leu Leu Tyr Ser Xaa Ile Pro Arg Met 
        35                  40                  45              


Gln Glu Pro Gly Gln Ile Val Glu Xaa Tyr Xaa Glu Glu Asp Pro Glu 
    50                  55                  60                  


Gly Ala Met Ser Val Val Ser Val Glu Xaa Ser Asp Asp Gly Xaa Xaa 
65                  70                  75                  80  


Arg Arg Xaa Glu Xaa Xaa Val Lys Lys Val Val Lys Xaa Val Xaa Xaa 
                85                  90                  95      


Arg Xaa Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val Asp 
            100                 105                 110         


Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Xaa Leu Gly Arg Asp Phe 
        115                 120                 125             


Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala Gly 
    130                 135                 140                 


Xaa Ala Xaa Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr Ser 
145                 150                 155                 160 


Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly Ser 
                165                 170                 175     


Leu Ser Arg Val Xaa Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met Glu 
            180                 185                 190         


Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro Gln 
        195                 200                 205             


Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro Glu 
    210                 215                 220                 


Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp Leu 
225                 230                 235                 240 


Asp Tyr Gly Met Met Ser Asp Tyr Gly Xaa Ala Arg Arg Xaa Gly Xaa 
                245                 250                 255     


Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile Gly 
            260                 265                 270         


Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln His 
        275                 280                 285             


Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly Pro 
    290                 295                 300                 


Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala Met 
305                 310                 315                 320 


Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr Leu 
                325                 330                 335     


Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Xaa Asp Val Arg Lys 
            340                 345                 350         


Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys Lys 
        355                 360                 365             


Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe Gly 
    370                 375                 380                 


Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val Pro 
385                 390                 395                 400 


Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Xaa Glu 
                405                 410                 415     


Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser Ser His Asp Ser Ile Lys 
            420                 425                 430         


Met Glu Ile Val Asp His Ala Leu His Ala Leu Xaa Asp Glu Val Ile 
        435                 440                 445             


Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys Pro 
    450                 455                 460                 


Arg His Ile Glu Trp Glu Ser Val Leu Xaa Asn Xaa Ala Gly Cys Leu 
465                 470                 475                 480 


Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg Glu 
                485                 490                 495     


Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu Ile 
            500                 505                 510         


Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys Leu 
        515                 520                 525             


Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala Glu 
    530                 535                 540                 


Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Xaa Gly Pro His 
545                 550                 555                 560 


Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Asp Glu Trp Phe Ser 
                565                 570                 575     


Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Xaa Val Asp Phe 
            580                 585                 590         


Pro Lys Arg Xaa Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro 
        595                 600                 605             


Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Xaa Pro 
    610                 615                 620                 


Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly 
625                 630                 635                 640 


Arg Trp Xaa Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys 
                645                 650                 655     


Ala Leu Ser Ala Ile Ala Asp Leu Leu Xaa Asn Glu His Glu Arg Val 
            660                 665                 670         


Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg 
        675                 680                 685             


Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn 
    690                 695                 700                 


Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Xaa 
705                 710                 715                 720 


Val Ile Ser Ile Leu Asn Xaa Ile Asn Glu Val Ile Ala Glu Asn Leu 
                725                 730                 735     


Glu Ala Ala Lys Lys Leu Arg Glu Xaa Gln Gly Ile Glu Lys Leu Val 
            740                 745                 750         


Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala 
        755                 760                 765             


Ala Leu Val Leu Gln Xaa Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro 
    770                 775                 780                 


Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn 
785                 790                 795                 800 


Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Xaa Leu 
                805                 810                 815     


Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu 
            820                 825                 830         


Glu Ile Gln Met Ser Asn Met Gly Ser Asn Xaa Lys Ser Leu Asp Asn 
        835                 840                 845             


Asn Tyr Ser Xaa Pro Asn Glu Arg Gly Asp His Asn Arg Xaa Leu Asp 
    850                 855                 860                 


Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Xaa Xaa Pro 
865                 870                 875                 880 


Leu Met Gln Asp Glu Gly Gln Glu Ser Leu Glu Glu Glu Leu Asp Val 
                885                 890                 895     


Leu Val Leu Asp Asp Glu Gly Gly Gln Val Ser Tyr Pro Ser Met Gln 
            900                 905                 910         


Lys Ile 
        


<210> 7256
<211> 918
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(912)
<223> Selenocysteine

<400> 7256
Met Asp Asp Ser Glu Val Glu Ser Xaa Ala Ser Ile Leu Ala Ser Val 
1               5                   10                  15      


Lys Glu Gln Glu Ala Gln Phe Glu Lys Leu Xaa Arg Ala Leu Glu Glu 
            20                  25                  30          


Glu Arg Arg His Val Ser Ala Gln Leu Glu Arg Val Arg Val Ser Pro 
        35                  40                  45              


Gln Asp Ala Asn Pro Leu Met Ala Asn Gly Xaa Leu Xaa Arg Arg His 
    50                  55                  60                  


Gln Asn Gly Arg Phe Val Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe 
65                  70                  75                  80  


Ser Asp Leu Lys Leu Asn Gly Pro Gln Asp His Ser His Leu Leu Tyr 
                85                  90                  95      


Ser Xaa Ile Pro Arg Met Gln Glu Pro Gly Gln Ile Val Glu Xaa Tyr 
            100                 105                 110         


Xaa Glu Glu Asp Pro Glu Gly Ala Met Ser Val Val Ser Val Glu Xaa 
        115                 120                 125             


Ser Asp Asp Gly Xaa Xaa Arg Arg Xaa Glu Xaa Xaa Val Lys Lys Val 
    130                 135                 140                 


Val Lys Xaa Val Xaa Xaa Arg Xaa Val Gln Pro Val Ala Met Gly Pro 
145                 150                 155                 160 


Asp Gly Leu Pro Val Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln 
                165                 170                 175     


Xaa Leu Gly Arg Asp Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro 
            180                 185                 190         


Tyr Val Gly Gln Ala Gly Xaa Ala Xaa Leu Pro Arg Asn Phe His Tyr 
        195                 200                 205             


Pro Pro Asp Gly Tyr Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly 
    210                 215                 220                 


Ser Asp Asn Tyr Gly Ser Leu Ser Arg Val Xaa Arg Ile Glu Glu Arg 
225                 230                 235                 240 


Tyr Arg Pro Ser Met Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val 
                245                 250                 255     


Tyr Gly Pro Gln Pro Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu 
            260                 265                 270         


His Arg Phe His Pro Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser 
        275                 280                 285             


Met Gly Tyr Asp Asp Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Xaa 
    290                 295                 300                 


Ala Arg Arg Xaa Gly Xaa Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser 
305                 310                 315                 320 


Tyr Glu Asp Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp 
                325                 330                 335     


Ala Pro Leu Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser 
            340                 345                 350         


Leu Arg Lys Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu 
        355                 360                 365             


Pro Glu Val Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser 
    370                 375                 380                 


Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val 
385                 390                 395                 400 


Lys Xaa Asp Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu 
                405                 410                 415     


Leu Asp His Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu 
            420                 425                 430         


Lys Asn Ile Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys 
        435                 440                 445             


Asn Cys Asp Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg 
    450                 455                 460                 


Asp Met Asp Leu Xaa Glu Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser 
465                 470                 475                 480 


Ser His Asp Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala 
                485                 490                 495     


Leu Xaa Asp Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro 
            500                 505                 510         


Asn Glu Asp Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Xaa 
        515                 520                 525             


Asn Xaa Ala Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala 
    530                 535                 540                 


Arg Arg Lys Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe 
545                 550                 555                 560 


Ile Val Gln Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val 
                565                 570                 575     


Glu Asn Cys Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg 
            580                 585                 590         


Glu Ile Pro Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala 
        595                 600                 605             


Asn Asn Xaa Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly 
    610                 615                 620                 


Lys Asp Glu Trp Phe Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala 
625                 630                 635                 640 


Asn Asp Xaa Val Asp Phe Pro Lys Arg Xaa Ser Pro Ala Arg Gly Tyr 
                645                 650                 655     


Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu 
            660                 665                 670         


Lys Glu Ser Lys Xaa Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile 
        675                 680                 685             


Gln Asn Leu Cys Ala Gly Arg Trp Xaa Tyr Gly Arg Tyr Ile Arg Ser 
    690                 695                 700                 


Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Xaa 
705                 710                 715                 720 


Asn Glu His Glu Arg Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn 
                725                 730                 735     


Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile 
            740                 745                 750         


Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp 
        755                 760                 765             


Asn Phe Ser Glu Asp Xaa Val Ile Ser Ile Leu Asn Xaa Ile Asn Glu 
    770                 775                 780                 


Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys Leu Arg Glu Xaa Gln 
785                 790                 795                 800 


Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu 
                805                 810                 815     


Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln Xaa Ile Trp Gly Tyr 
            820                 825                 830         


Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp 
        835                 840                 845             


Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser 
    850                 855                 860                 


Tyr Asp Asp Ser Xaa Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp 
865                 870                 875                 880 


Asn Asn Tyr Ser Xaa Pro Asn Glu Arg Gly Asp His Asn Arg Xaa Leu 
                885                 890                 895     


Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Xaa Xaa 
            900                 905                 910         


Pro Leu Met Gln Lys Ile 
        915             


<210> 7257
<211> 933
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(927)
<223> Selenocysteine

<400> 7257
Met Asp Asp Ser Glu Val Glu Ser Xaa Ala Ser Ile Leu Ala Ser Val 
1               5                   10                  15      


Lys Glu Gln Glu Ala Gln Phe Glu Lys Leu Xaa Arg Ala Leu Glu Glu 
            20                  25                  30          


Glu Arg Arg His Val Ser Ala Gln Leu Glu Arg Val Arg Val Ser Pro 
        35                  40                  45              


Gln Asp Ala Asn Pro Leu Met Ala Asn Gly Xaa Leu Xaa Arg Arg His 
    50                  55                  60                  


Gln Asn Gly Arg Phe Val Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe 
65                  70                  75                  80  


Ser Asp Leu Lys Leu Asn Gly Pro Gln Asp His Ser His Leu Leu Tyr 
                85                  90                  95      


Ser Xaa Ile Pro Arg Met Gln Glu Pro Gly Gln Ile Val Glu Xaa Tyr 
            100                 105                 110         


Xaa Glu Glu Asp Pro Glu Gly Ala Met Ser Val Val Ser Val Glu Xaa 
        115                 120                 125             


Ser Asp Asp Gly Xaa Xaa Arg Arg Xaa Glu Xaa Xaa Val Lys Lys Val 
    130                 135                 140                 


Val Lys Xaa Val Xaa Xaa Arg Xaa Val Gln Pro Val Ala Met Gly Pro 
145                 150                 155                 160 


Asp Gly Leu Pro Val Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln 
                165                 170                 175     


Xaa Leu Gly Arg Asp Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro 
            180                 185                 190         


Tyr Val Gly Gln Ala Gly Xaa Ala Xaa Leu Pro Arg Asn Phe His Tyr 
        195                 200                 205             


Pro Pro Asp Gly Tyr Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly 
    210                 215                 220                 


Ser Asp Asn Tyr Gly Ser Leu Ser Arg Val Xaa Arg Ile Glu Glu Arg 
225                 230                 235                 240 


Tyr Arg Pro Ser Met Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val 
                245                 250                 255     


Tyr Gly Pro Gln Pro Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu 
            260                 265                 270         


His Arg Phe His Pro Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser 
        275                 280                 285             


Met Gly Tyr Asp Asp Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Xaa 
    290                 295                 300                 


Ala Arg Arg Xaa Gly Xaa Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser 
305                 310                 315                 320 


Tyr Glu Asp Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp 
                325                 330                 335     


Ala Pro Leu Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser 
            340                 345                 350         


Leu Arg Lys Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu 
        355                 360                 365             


Pro Glu Val Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser 
    370                 375                 380                 


Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val 
385                 390                 395                 400 


Lys Xaa Asp Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu 
                405                 410                 415     


Leu Asp His Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu 
            420                 425                 430         


Lys Asn Ile Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys 
        435                 440                 445             


Asn Cys Asp Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg 
    450                 455                 460                 


Asp Met Asp Leu Xaa Glu Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser 
465                 470                 475                 480 


Ser His Asp Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala 
                485                 490                 495     


Leu Xaa Asp Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro 
            500                 505                 510         


Asn Glu Asp Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Xaa 
        515                 520                 525             


Asn Xaa Ala Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala 
    530                 535                 540                 


Arg Arg Lys Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe 
545                 550                 555                 560 


Ile Val Gln Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val 
                565                 570                 575     


Glu Asn Cys Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg 
            580                 585                 590         


Glu Ile Pro Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala 
        595                 600                 605             


Asn Asn Xaa Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly 
    610                 615                 620                 


Lys Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Xaa Val Asp Phe 
625                 630                 635                 640 


Pro Lys Arg Xaa Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro 
                645                 650                 655     


Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Xaa Pro 
            660                 665                 670         


Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly 
        675                 680                 685             


Arg Trp Xaa Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys 
    690                 695                 700                 


Ala Leu Ser Ala Ile Ala Asp Leu Leu Xaa Asn Glu His Glu Arg Val 
705                 710                 715                 720 


Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg 
                725                 730                 735     


Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn 
            740                 745                 750         


Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Xaa 
        755                 760                 765             


Val Ile Ser Ile Leu Asn Xaa Ile Asn Glu Val Ile Ala Glu Asn Leu 
    770                 775                 780                 


Glu Ala Ala Lys Lys Leu Arg Glu Xaa Gln Gly Ile Glu Lys Leu Val 
785                 790                 795                 800 


Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala 
                805                 810                 815     


Ala Leu Val Leu Gln Xaa Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro 
            820                 825                 830         


Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn 
        835                 840                 845             


Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Xaa Leu 
    850                 855                 860                 


Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu 
865                 870                 875                 880 


Glu Ile Gln Met Ser Asn Met Gly Ser Asn Xaa Lys Ser Leu Asp Asn 
                885                 890                 895     


Asn Tyr Ser Xaa Pro Asn Glu Arg Gly Asp His Asn Arg Xaa Leu Asp 
            900                 905                 910         


Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Xaa Xaa Pro 
        915                 920                 925             


Leu Met Gln Lys Ile 
    930             


<210> 7258
<211> 938
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(933)
<223> Selenocysteine

<400> 7258
Met Asp Asp Ser Glu Val Glu Ser Xaa Ala Ser Ile Leu Ala Ser Val 
1               5                   10                  15      


Lys Glu Gln Glu Ala Gln Phe Glu Lys Leu Xaa Arg Ala Leu Glu Glu 
            20                  25                  30          


Glu Arg Arg His Val Ser Ala Gln Leu Glu Arg Val Arg Val Ser Pro 
        35                  40                  45              


Gln Asp Ala Asn Pro Leu Met Ala Asn Gly Xaa Leu Xaa Arg Arg His 
    50                  55                  60                  


Gln Asn Gly Arg Phe Val Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe 
65                  70                  75                  80  


Ser Asp Leu Lys Leu Asn Gly Pro Gln Asp His Ser His Leu Leu Tyr 
                85                  90                  95      


Ser Xaa Ile Pro Arg Met Gln Glu Pro Gly Gln Ile Val Glu Xaa Tyr 
            100                 105                 110         


Xaa Glu Glu Asp Pro Glu Gly Ala Met Ser Val Val Ser Val Glu Xaa 
        115                 120                 125             


Ser Asp Asp Gly Xaa Xaa Arg Arg Xaa Glu Xaa Xaa Val Lys Lys Val 
    130                 135                 140                 


Val Lys Xaa Val Xaa Xaa Arg Xaa Val Gln Pro Val Ala Met Gly Pro 
145                 150                 155                 160 


Asp Gly Leu Pro Val Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln 
                165                 170                 175     


Xaa Leu Gly Arg Asp Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro 
            180                 185                 190         


Tyr Val Gly Gln Ala Gly Xaa Ala Xaa Leu Pro Arg Asn Phe His Tyr 
        195                 200                 205             


Pro Pro Asp Gly Tyr Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly 
    210                 215                 220                 


Ser Asp Asn Tyr Gly Ser Leu Ser Arg Val Xaa Arg Ile Glu Glu Arg 
225                 230                 235                 240 


Tyr Arg Pro Ser Met Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val 
                245                 250                 255     


Tyr Gly Pro Gln Pro Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu 
            260                 265                 270         


His Arg Phe His Pro Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser 
        275                 280                 285             


Met Gly Tyr Asp Asp Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Xaa 
    290                 295                 300                 


Ala Arg Arg Xaa Gly Xaa Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser 
305                 310                 315                 320 


Tyr Glu Asp Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp 
                325                 330                 335     


Ala Pro Leu Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser 
            340                 345                 350         


Leu Arg Lys Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu 
        355                 360                 365             


Pro Glu Val Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser 
    370                 375                 380                 


Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val 
385                 390                 395                 400 


Lys Xaa Asp Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu 
                405                 410                 415     


Leu Asp His Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu 
            420                 425                 430         


Lys Asn Ile Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys 
        435                 440                 445             


Asn Cys Asp Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg 
    450                 455                 460                 


Asp Met Asp Leu Xaa Glu Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser 
465                 470                 475                 480 


Ser His Asp Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala 
                485                 490                 495     


Leu Xaa Asp Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro 
            500                 505                 510         


Asn Glu Asp Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Xaa 
        515                 520                 525             


Asn Xaa Ala Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala 
    530                 535                 540                 


Arg Arg Lys Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe 
545                 550                 555                 560 


Ile Val Gln Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val 
                565                 570                 575     


Glu Asn Cys Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg 
            580                 585                 590         


Glu Ile Pro Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala 
        595                 600                 605             


Asn Asn Xaa Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly 
    610                 615                 620                 


Lys Asp Glu Trp Phe Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala 
625                 630                 635                 640 


Asn Asp Xaa Val Asp Phe Pro Lys Arg Xaa Ser Pro Ala Arg Gly Tyr 
                645                 650                 655     


Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu 
            660                 665                 670         


Lys Glu Ser Lys Xaa Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile 
        675                 680                 685             


Gln Asn Leu Cys Ala Gly Arg Trp Xaa Tyr Gly Arg Tyr Ile Arg Ser 
    690                 695                 700                 


Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Xaa 
705                 710                 715                 720 


Asn Glu His Glu Arg Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn 
                725                 730                 735     


Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile 
            740                 745                 750         


Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp 
        755                 760                 765             


Asn Phe Ser Glu Asp Xaa Val Ile Ser Ile Leu Asn Xaa Ile Asn Glu 
    770                 775                 780                 


Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys Leu Arg Glu Xaa Gln 
785                 790                 795                 800 


Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu 
                805                 810                 815     


Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln Xaa Ile Trp Gly Tyr 
            820                 825                 830         


Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp 
        835                 840                 845             


Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser 
    850                 855                 860                 


Tyr Asp Asp Ser Xaa Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp 
865                 870                 875                 880 


Lys Lys Pro Asp Arg Glu Glu Ile Gln Met Ser Asn Met Gly Ser Asn 
                885                 890                 895     


Xaa Lys Ser Leu Asp Asn Asn Tyr Ser Xaa Pro Asn Glu Arg Gly Asp 
            900                 905                 910         


His Asn Arg Xaa Leu Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro 
        915                 920                 925             


Leu Lys Gly Xaa Xaa Pro Leu Met Lys Ile 
    930                 935             


<210> 7259
<211> 939
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(933)
<223> Selenocysteine

<400> 7259
Met Asp Asp Ser Glu Val Glu Ser Xaa Ala Ser Ile Leu Ala Ser Val 
1               5                   10                  15      


Lys Glu Gln Glu Ala Gln Phe Glu Lys Leu Xaa Arg Ala Leu Glu Glu 
            20                  25                  30          


Glu Arg Arg His Val Ser Ala Gln Leu Glu Arg Val Arg Val Ser Pro 
        35                  40                  45              


Gln Asp Ala Asn Pro Leu Met Ala Asn Gly Xaa Leu Xaa Arg Arg His 
    50                  55                  60                  


Gln Asn Gly Arg Phe Val Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe 
65                  70                  75                  80  


Ser Asp Leu Lys Leu Asn Gly Pro Gln Asp His Ser His Leu Leu Tyr 
                85                  90                  95      


Ser Xaa Ile Pro Arg Met Gln Glu Pro Gly Gln Ile Val Glu Xaa Tyr 
            100                 105                 110         


Xaa Glu Glu Asp Pro Glu Gly Ala Met Ser Val Val Ser Val Glu Xaa 
        115                 120                 125             


Ser Asp Asp Gly Xaa Xaa Arg Arg Xaa Glu Xaa Xaa Val Lys Lys Val 
    130                 135                 140                 


Val Lys Xaa Val Xaa Xaa Arg Xaa Val Gln Pro Val Ala Met Gly Pro 
145                 150                 155                 160 


Asp Gly Leu Pro Val Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln 
                165                 170                 175     


Xaa Leu Gly Arg Asp Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro 
            180                 185                 190         


Tyr Val Gly Gln Ala Gly Xaa Ala Xaa Leu Pro Arg Asn Phe His Tyr 
        195                 200                 205             


Pro Pro Asp Gly Tyr Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly 
    210                 215                 220                 


Ser Asp Asn Tyr Gly Ser Leu Ser Arg Val Xaa Arg Ile Glu Glu Arg 
225                 230                 235                 240 


Tyr Arg Pro Ser Met Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val 
                245                 250                 255     


Tyr Gly Pro Gln Pro Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu 
            260                 265                 270         


His Arg Phe His Pro Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser 
        275                 280                 285             


Met Gly Tyr Asp Asp Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Xaa 
    290                 295                 300                 


Ala Arg Arg Xaa Gly Xaa Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser 
305                 310                 315                 320 


Tyr Glu Asp Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp 
                325                 330                 335     


Ala Pro Leu Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser 
            340                 345                 350         


Leu Arg Lys Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu 
        355                 360                 365             


Pro Glu Val Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser 
    370                 375                 380                 


Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val 
385                 390                 395                 400 


Lys Xaa Asp Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu 
                405                 410                 415     


Leu Asp His Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu 
            420                 425                 430         


Lys Asn Ile Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys 
        435                 440                 445             


Asn Cys Asp Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg 
    450                 455                 460                 


Asp Met Asp Leu Xaa Glu Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser 
465                 470                 475                 480 


Ser His Asp Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala 
                485                 490                 495     


Leu Xaa Asp Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro 
            500                 505                 510         


Asn Glu Asp Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Xaa 
        515                 520                 525             


Asn Xaa Ala Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala 
    530                 535                 540                 


Arg Arg Lys Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe 
545                 550                 555                 560 


Ile Val Gln Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val 
                565                 570                 575     


Glu Asn Cys Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg 
            580                 585                 590         


Glu Ile Pro Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala 
        595                 600                 605             


Asn Asn Xaa Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly 
    610                 615                 620                 


Lys Asp Glu Trp Phe Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala 
625                 630                 635                 640 


Asn Asp Xaa Val Asp Phe Pro Lys Arg Xaa Ser Pro Ala Arg Gly Tyr 
                645                 650                 655     


Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu 
            660                 665                 670         


Lys Glu Ser Lys Xaa Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile 
        675                 680                 685             


Gln Asn Leu Cys Ala Gly Arg Trp Xaa Tyr Gly Arg Tyr Ile Arg Ser 
    690                 695                 700                 


Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Xaa 
705                 710                 715                 720 


Asn Glu His Glu Arg Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn 
                725                 730                 735     


Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile 
            740                 745                 750         


Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp 
        755                 760                 765             


Asn Phe Ser Glu Asp Xaa Val Ile Ser Ile Leu Asn Xaa Ile Asn Glu 
    770                 775                 780                 


Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys Leu Arg Glu Xaa Gln 
785                 790                 795                 800 


Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu 
                805                 810                 815     


Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln Xaa Ile Trp Gly Tyr 
            820                 825                 830         


Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp 
        835                 840                 845             


Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser 
    850                 855                 860                 


Tyr Asp Asp Ser Xaa Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp 
865                 870                 875                 880 


Lys Lys Pro Asp Arg Glu Glu Ile Gln Met Ser Asn Met Gly Ser Asn 
                885                 890                 895     


Xaa Lys Ser Leu Asp Asn Asn Tyr Ser Xaa Pro Asn Glu Arg Gly Asp 
            900                 905                 910         


His Asn Arg Xaa Leu Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro 
        915                 920                 925             


Leu Lys Gly Xaa Xaa Pro Leu Met Gln Lys Ile 
    930                 935                 


<210> 7260
<211> 941
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(906)
<223> Selenocysteine

<400> 7260
Met Asp Asp Ser Glu Val Glu Ser Xaa Ala Ser Ile Leu Ala Ser Val 
1               5                   10                  15      


Lys Glu Gln Glu Ala Gln Phe Glu Lys Leu Xaa Arg Ala Leu Glu Glu 
            20                  25                  30          


Glu Arg Arg His Val Ser Ala Gln Leu Glu Arg Val Arg Val Ser Pro 
        35                  40                  45              


Gln Asp Ala Asn Pro Leu Met Ala Asn Gly Xaa Leu Xaa Arg Arg His 
    50                  55                  60                  


Gln Asn Gly Arg Phe Val Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe 
65                  70                  75                  80  


Ser Asp Leu Lys Leu Asn Gly Pro Gln Asp His Ser His Leu Leu Tyr 
                85                  90                  95      


Ser Xaa Ile Pro Arg Met Gln Glu Pro Gly Gln Ile Val Glu Xaa Tyr 
            100                 105                 110         


Xaa Glu Glu Asp Pro Glu Gly Ala Met Ser Val Val Ser Val Glu Xaa 
        115                 120                 125             


Ser Asp Asp Gly Xaa Xaa Arg Arg Xaa Glu Xaa Xaa Val Lys Lys Val 
    130                 135                 140                 


Val Lys Xaa Val Xaa Xaa Arg Xaa Val Gln Pro Val Ala Met Gly Pro 
145                 150                 155                 160 


Asp Gly Leu Pro Val Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln 
                165                 170                 175     


Xaa Leu Gly Arg Asp Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro 
            180                 185                 190         


Tyr Val Gly Gln Ala Gly Xaa Ala Xaa Leu Pro Arg Asn Phe His Tyr 
        195                 200                 205             


Pro Pro Asp Gly Tyr Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly 
    210                 215                 220                 


Ser Asp Asn Tyr Gly Ser Leu Ser Arg Val Xaa Arg Ile Glu Glu Arg 
225                 230                 235                 240 


Tyr Arg Pro Ser Met Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val 
                245                 250                 255     


Tyr Gly Pro Gln Pro Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu 
            260                 265                 270         


His Arg Phe His Pro Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser 
        275                 280                 285             


Met Gly Tyr Asp Asp Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Xaa 
    290                 295                 300                 


Ala Arg Arg Xaa Gly Xaa Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser 
305                 310                 315                 320 


Tyr Glu Asp Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp 
                325                 330                 335     


Ala Pro Leu Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser 
            340                 345                 350         


Leu Arg Lys Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu 
        355                 360                 365             


Pro Glu Val Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser 
    370                 375                 380                 


Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val 
385                 390                 395                 400 


Lys Xaa Asp Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu 
                405                 410                 415     


Leu Asp His Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu 
            420                 425                 430         


Lys Asn Ile Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys 
        435                 440                 445             


Asn Cys Asp Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg 
    450                 455                 460                 


Asp Met Asp Leu Xaa Glu Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser 
465                 470                 475                 480 


Ser His Asp Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala 
                485                 490                 495     


Leu Xaa Asp Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro 
            500                 505                 510         


Asn Glu Asp Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Xaa 
        515                 520                 525             


Asn Xaa Ala Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala 
    530                 535                 540                 


Arg Arg Lys Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe 
545                 550                 555                 560 


Ile Val Gln Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val 
                565                 570                 575     


Glu Asn Cys Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg 
            580                 585                 590         


Glu Ile Pro Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala 
        595                 600                 605             


Asn Asn Xaa Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly 
    610                 615                 620                 


Lys Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Xaa Val Asp Phe 
625                 630                 635                 640 


Pro Lys Arg Xaa Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro 
                645                 650                 655     


Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Xaa Pro 
            660                 665                 670         


Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly 
        675                 680                 685             


Arg Trp Xaa Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys 
    690                 695                 700                 


Ala Leu Ser Ala Ile Ala Asp Leu Leu Xaa Asn Glu His Glu Arg Val 
705                 710                 715                 720 


Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg 
                725                 730                 735     


Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn 
            740                 745                 750         


Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Xaa 
        755                 760                 765             


Val Ile Ser Ile Leu Asn Xaa Ile Asn Glu Val Ile Ala Glu Asn Leu 
    770                 775                 780                 


Glu Ala Ala Lys Lys Leu Arg Glu Xaa Gln Gly Ile Glu Lys Leu Val 
785                 790                 795                 800 


Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala 
                805                 810                 815     


Ala Leu Val Leu Gln Xaa Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro 
            820                 825                 830         


Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn 
        835                 840                 845             


Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Xaa Leu 
    850                 855                 860                 


Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Asn Asn Tyr Ser Xaa Pro 
865                 870                 875                 880 


Asn Glu Arg Gly Asp His Asn Arg Xaa Leu Asp Arg Ser Gly Asp Leu 
                885                 890                 895     


Gly Asp Met Glu Pro Leu Lys Gly Xaa Xaa Pro Leu Met Gln Asp Glu 
            900                 905                 910         


Gly Gln Glu Ser Leu Glu Glu Glu Leu Asp Val Leu Val Leu Asp Asp 
        915                 920                 925             


Glu Gly Gly Gln Val Ser Tyr Pro Ser Met Gln Lys Ile 
    930                 935                 940     


<210> 7261
<211> 962
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (863)..(863)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (900)..(900)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (926)..(927)
<223> Selenocysteine

<400> 7261
Met Asp Asp Ser Glu Val Glu Ser Xaa Ala Ser Ile Leu Ala Ser Val 
1               5                   10                  15      


Lys Glu Gln Glu Ala Gln Phe Glu Lys Leu Xaa Arg Ala Leu Glu Glu 
            20                  25                  30          


Glu Arg Arg His Val Ser Ala Gln Leu Glu Arg Val Arg Val Ser Pro 
        35                  40                  45              


Gln Asp Ala Asn Pro Leu Met Ala Asn Gly Xaa Leu Xaa Arg Arg His 
    50                  55                  60                  


Gln Asn Gly Arg Phe Val Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe 
65                  70                  75                  80  


Ser Asp Leu Lys Leu Asn Gly Pro Gln Asp His Ser His Leu Leu Tyr 
                85                  90                  95      


Ser Xaa Ile Pro Arg Met Gln Glu Pro Gly Gln Ile Val Glu Xaa Tyr 
            100                 105                 110         


Xaa Glu Glu Asp Pro Glu Gly Ala Met Ser Val Val Ser Val Glu Xaa 
        115                 120                 125             


Ser Asp Asp Gly Xaa Xaa Arg Arg Xaa Glu Xaa Xaa Val Lys Lys Val 
    130                 135                 140                 


Val Lys Xaa Val Xaa Xaa Arg Xaa Val Gln Pro Val Ala Met Gly Pro 
145                 150                 155                 160 


Asp Gly Leu Pro Val Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln 
                165                 170                 175     


Xaa Leu Gly Arg Asp Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro 
            180                 185                 190         


Tyr Val Gly Gln Ala Gly Xaa Ala Xaa Leu Pro Arg Asn Phe His Tyr 
        195                 200                 205             


Pro Pro Asp Gly Tyr Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly 
    210                 215                 220                 


Ser Asp Asn Tyr Gly Ser Leu Ser Arg Val Xaa Arg Ile Glu Glu Arg 
225                 230                 235                 240 


Tyr Arg Pro Ser Met Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val 
                245                 250                 255     


Tyr Gly Pro Gln Pro Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu 
            260                 265                 270         


His Arg Phe His Pro Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser 
        275                 280                 285             


Met Gly Tyr Asp Asp Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Xaa 
    290                 295                 300                 


Ala Arg Arg Xaa Gly Xaa Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser 
305                 310                 315                 320 


Tyr Glu Asp Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp 
                325                 330                 335     


Ala Pro Leu Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser 
            340                 345                 350         


Leu Arg Lys Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu 
        355                 360                 365             


Pro Glu Val Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser 
    370                 375                 380                 


Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val 
385                 390                 395                 400 


Lys Xaa Asp Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu 
                405                 410                 415     


Leu Asp His Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu 
            420                 425                 430         


Lys Asn Ile Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys 
        435                 440                 445             


Asn Cys Asp Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg 
    450                 455                 460                 


Asp Met Asp Leu Xaa Glu Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser 
465                 470                 475                 480 


Ser His Asp Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala 
                485                 490                 495     


Leu Xaa Asp Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro 
            500                 505                 510         


Asn Glu Asp Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Xaa 
        515                 520                 525             


Asn Xaa Ala Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala 
    530                 535                 540                 


Arg Arg Lys Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe 
545                 550                 555                 560 


Ile Val Gln Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val 
                565                 570                 575     


Glu Asn Cys Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg 
            580                 585                 590         


Glu Ile Pro Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala 
        595                 600                 605             


Asn Asn Xaa Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly 
    610                 615                 620                 


Lys Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Xaa Val Asp Phe 
625                 630                 635                 640 


Pro Lys Arg Xaa Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro 
                645                 650                 655     


Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Xaa Pro 
            660                 665                 670         


Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly 
        675                 680                 685             


Arg Trp Xaa Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys 
    690                 695                 700                 


Ala Leu Ser Ala Ile Ala Asp Leu Leu Xaa Asn Glu His Glu Arg Val 
705                 710                 715                 720 


Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg 
                725                 730                 735     


Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn 
            740                 745                 750         


Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Xaa 
        755                 760                 765             


Val Ile Ser Ile Leu Asn Xaa Ile Asn Glu Val Ile Ala Glu Asn Leu 
    770                 775                 780                 


Glu Ala Ala Lys Lys Leu Arg Glu Xaa Gln Gly Ile Glu Lys Leu Val 
785                 790                 795                 800 


Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala 
                805                 810                 815     


Ala Leu Val Leu Gln Xaa Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro 
            820                 825                 830         


Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn 
        835                 840                 845             


Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Xaa Leu 
    850                 855                 860                 


Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu 
865                 870                 875                 880 


Glu Ile Gln Met Ser Asn Met Gly Ser Asn Xaa Lys Ser Leu Asp Asn 
                885                 890                 895     


Asn Tyr Ser Xaa Pro Asn Glu Arg Gly Asp His Asn Arg Xaa Leu Asp 
            900                 905                 910         


Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Xaa Xaa Pro 
        915                 920                 925             


Leu Met Gln Asp Glu Gly Gln Glu Ser Leu Glu Glu Glu Leu Asp Val 
    930                 935                 940                 


Leu Val Leu Asp Asp Glu Gly Gly Gln Val Ser Tyr Pro Ser Met Gln 
945                 950                 955                 960 


Lys Ile 
        


<210> 7262
<211> 968
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (932)..(933)
<223> Selenocysteine

<400> 7262
Met Asp Asp Ser Glu Val Glu Ser Xaa Ala Ser Ile Leu Ala Ser Val 
1               5                   10                  15      


Lys Glu Gln Glu Ala Gln Phe Glu Lys Leu Xaa Arg Ala Leu Glu Glu 
            20                  25                  30          


Glu Arg Arg His Val Ser Ala Gln Leu Glu Arg Val Arg Val Ser Pro 
        35                  40                  45              


Gln Asp Ala Asn Pro Leu Met Ala Asn Gly Xaa Leu Xaa Arg Arg His 
    50                  55                  60                  


Gln Asn Gly Arg Phe Val Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe 
65                  70                  75                  80  


Ser Asp Leu Lys Leu Asn Gly Pro Gln Asp His Ser His Leu Leu Tyr 
                85                  90                  95      


Ser Xaa Ile Pro Arg Met Gln Glu Pro Gly Gln Ile Val Glu Xaa Tyr 
            100                 105                 110         


Xaa Glu Glu Asp Pro Glu Gly Ala Met Ser Val Val Ser Val Glu Xaa 
        115                 120                 125             


Ser Asp Asp Gly Xaa Xaa Arg Arg Xaa Glu Xaa Xaa Val Lys Lys Val 
    130                 135                 140                 


Val Lys Xaa Val Xaa Xaa Arg Xaa Val Gln Pro Val Ala Met Gly Pro 
145                 150                 155                 160 


Asp Gly Leu Pro Val Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln 
                165                 170                 175     


Xaa Leu Gly Arg Asp Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro 
            180                 185                 190         


Tyr Val Gly Gln Ala Gly Xaa Ala Xaa Leu Pro Arg Asn Phe His Tyr 
        195                 200                 205             


Pro Pro Asp Gly Tyr Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly 
    210                 215                 220                 


Ser Asp Asn Tyr Gly Ser Leu Ser Arg Val Xaa Arg Ile Glu Glu Arg 
225                 230                 235                 240 


Tyr Arg Pro Ser Met Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val 
                245                 250                 255     


Tyr Gly Pro Gln Pro Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu 
            260                 265                 270         


His Arg Phe His Pro Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser 
        275                 280                 285             


Met Gly Tyr Asp Asp Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Xaa 
    290                 295                 300                 


Ala Arg Arg Xaa Gly Xaa Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser 
305                 310                 315                 320 


Tyr Glu Asp Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp 
                325                 330                 335     


Ala Pro Leu Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser 
            340                 345                 350         


Leu Arg Lys Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu 
        355                 360                 365             


Pro Glu Val Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser 
    370                 375                 380                 


Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val 
385                 390                 395                 400 


Lys Xaa Asp Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu 
                405                 410                 415     


Leu Asp His Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu 
            420                 425                 430         


Lys Asn Ile Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys 
        435                 440                 445             


Asn Cys Asp Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg 
    450                 455                 460                 


Asp Met Asp Leu Xaa Glu Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser 
465                 470                 475                 480 


Ser His Asp Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala 
                485                 490                 495     


Leu Xaa Asp Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro 
            500                 505                 510         


Asn Glu Asp Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Xaa 
        515                 520                 525             


Asn Xaa Ala Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala 
    530                 535                 540                 


Arg Arg Lys Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe 
545                 550                 555                 560 


Ile Val Gln Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val 
                565                 570                 575     


Glu Asn Cys Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg 
            580                 585                 590         


Glu Ile Pro Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala 
        595                 600                 605             


Asn Asn Xaa Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly 
    610                 615                 620                 


Lys Asp Glu Trp Phe Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala 
625                 630                 635                 640 


Asn Asp Xaa Val Asp Phe Pro Lys Arg Xaa Ser Pro Ala Arg Gly Tyr 
                645                 650                 655     


Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu 
            660                 665                 670         


Lys Glu Ser Lys Xaa Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile 
        675                 680                 685             


Gln Asn Leu Cys Ala Gly Arg Trp Xaa Tyr Gly Arg Tyr Ile Arg Ser 
    690                 695                 700                 


Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Xaa 
705                 710                 715                 720 


Asn Glu His Glu Arg Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn 
                725                 730                 735     


Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile 
            740                 745                 750         


Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp 
        755                 760                 765             


Asn Phe Ser Glu Asp Xaa Val Ile Ser Ile Leu Asn Xaa Ile Asn Glu 
    770                 775                 780                 


Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys Leu Arg Glu Xaa Gln 
785                 790                 795                 800 


Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu 
                805                 810                 815     


Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln Xaa Ile Trp Gly Tyr 
            820                 825                 830         


Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp 
        835                 840                 845             


Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser 
    850                 855                 860                 


Tyr Asp Asp Ser Xaa Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp 
865                 870                 875                 880 


Lys Lys Pro Asp Arg Glu Glu Ile Gln Met Ser Asn Met Gly Ser Asn 
                885                 890                 895     


Xaa Lys Ser Leu Asp Asn Asn Tyr Ser Xaa Pro Asn Glu Arg Gly Asp 
            900                 905                 910         


His Asn Arg Xaa Leu Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro 
        915                 920                 925             


Leu Lys Gly Xaa Xaa Pro Leu Met Gln Asp Glu Gly Gln Glu Ser Leu 
    930                 935                 940                 


Glu Glu Glu Leu Asp Val Leu Val Leu Asp Asp Glu Gly Gly Gln Val 
945                 950                 955                 960 


Ser Tyr Pro Ser Met Gln Lys Ile 
                965             


<210> 7263
<211> 126
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<400> 7263
Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu 
1               5                   10                  15      


Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys 
            20                  25                  30          


Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val 
        35                  40                  45              


Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala 
    50                  55                  60                  


Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Xaa Asp 
65                  70                  75                  80  


Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His 
                85                  90                  95      


Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile 
            100                 105                 110         


Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn 
        115                 120                 125     


<210> 7264
<211> 610
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(604)
<223> Selenocysteine

<400> 7264
Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu 
1               5                   10                  15      


Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys 
            20                  25                  30          


Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val 
        35                  40                  45              


Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala 
    50                  55                  60                  


Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Xaa Asp 
65                  70                  75                  80  


Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His 
                85                  90                  95      


Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile 
            100                 105                 110         


Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp 
        115                 120                 125             


Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp 
    130                 135                 140                 


Leu Xaa Glu Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser Ser His Asp 
145                 150                 155                 160 


Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Xaa Asp 
                165                 170                 175     


Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp 
            180                 185                 190         


Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Xaa Asn Xaa Ala 
        195                 200                 205             


Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys 
    210                 215                 220                 


Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln 
225                 230                 235                 240 


Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys 
                245                 250                 255     


Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro 
            260                 265                 270         


Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Xaa 
        275                 280                 285             


Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys 
    290                 295                 300                 


Lys Pro Ile Glu Asp Pro Ala Asn Asp Xaa Val Asp Phe Pro Lys Arg 
305                 310                 315                 320 


Xaa Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val 
                325                 330                 335     


Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Xaa Pro Ala Ile Leu 
            340                 345                 350         


Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Xaa 
        355                 360                 365             


Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser 
    370                 375                 380                 


Ala Ile Ala Asp Leu Leu Xaa Asn Glu His Glu Arg Val Val Lys Ala 
385                 390                 395                 400 


Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu 
                405                 410                 415     


Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly 
            420                 425                 430         


Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Xaa Val Ile Ser 
        435                 440                 445             


Ile Leu Asn Xaa Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala 
    450                 455                 460                 


Lys Lys Leu Arg Glu Xaa Gln Gly Ile Glu Lys Leu Val Leu Ile Asn 
465                 470                 475                 480 


Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val 
                485                 490                 495     


Leu Gln Xaa Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys 
            500                 505                 510         


Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser 
        515                 520                 525             


Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Xaa Leu Pro Leu Ile 
    530                 535                 540                 


Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu Glu Ile Gln 
545                 550                 555                 560 


Met Ser Asn Met Gly Ser Asn Xaa Lys Ser Leu Asp Asn Asn Tyr Ser 
                565                 570                 575     


Xaa Pro Asn Glu Arg Gly Asp His Asn Arg Xaa Leu Asp Arg Ser Gly 
            580                 585                 590         


Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Xaa Xaa Pro Leu Met Gln 
        595                 600                 605             


Lys Ile 
    610 


<210> 7265
<211> 616
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(610)
<223> Selenocysteine

<400> 7265
Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu 
1               5                   10                  15      


Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys 
            20                  25                  30          


Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val 
        35                  40                  45              


Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala 
    50                  55                  60                  


Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Xaa Asp 
65                  70                  75                  80  


Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His 
                85                  90                  95      


Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile 
            100                 105                 110         


Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp 
        115                 120                 125             


Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp 
    130                 135                 140                 


Leu Xaa Glu Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser Ser His Asp 
145                 150                 155                 160 


Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Xaa Asp 
                165                 170                 175     


Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp 
            180                 185                 190         


Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Xaa Asn Xaa Ala 
        195                 200                 205             


Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys 
    210                 215                 220                 


Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln 
225                 230                 235                 240 


Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys 
                245                 250                 255     


Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro 
            260                 265                 270         


Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Xaa 
        275                 280                 285             


Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Asp Glu 
    290                 295                 300                 


Trp Phe Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Xaa 
305                 310                 315                 320 


Val Asp Phe Pro Lys Arg Xaa Ser Pro Ala Arg Gly Tyr Glu Leu Leu 
                325                 330                 335     


Phe Gln Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser 
            340                 345                 350         


Lys Xaa Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu 
        355                 360                 365             


Cys Ala Gly Arg Trp Xaa Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg 
    370                 375                 380                 


Gln Glu Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Xaa Asn Glu His 
385                 390                 395                 400 


Glu Arg Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val 
                405                 410                 415     


Asp Ala Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu 
            420                 425                 430         


Val Lys Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser 
        435                 440                 445             


Glu Asp Xaa Val Ile Ser Ile Leu Asn Xaa Ile Asn Glu Val Ile Ala 
    450                 455                 460                 


Glu Asn Leu Glu Ala Ala Lys Lys Leu Arg Glu Xaa Gln Gly Ile Glu 
465                 470                 475                 480 


Lys Leu Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val 
                485                 490                 495     


Arg Ala Ala Ala Leu Val Leu Gln Xaa Ile Trp Gly Tyr Lys Glu Leu 
            500                 505                 510         


Arg Lys Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val 
        515                 520                 525             


Asn Leu Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp 
    530                 535                 540                 


Ser Xaa Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro 
545                 550                 555                 560 


Asp Arg Glu Glu Ile Gln Met Ser Asn Met Gly Ser Asn Xaa Lys Ser 
                565                 570                 575     


Leu Asp Asn Asn Tyr Ser Xaa Pro Asn Glu Arg Gly Asp His Asn Arg 
            580                 585                 590         


Xaa Leu Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly 
        595                 600                 605             


Xaa Xaa Pro Leu Met Gln Lys Ile 
    610                 615     


<210> 7266
<211> 618
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (566)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(583)
<223> Selenocysteine

<400> 7266
Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu 
1               5                   10                  15      


Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys 
            20                  25                  30          


Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val 
        35                  40                  45              


Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala 
    50                  55                  60                  


Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Xaa Asp 
65                  70                  75                  80  


Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His 
                85                  90                  95      


Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile 
            100                 105                 110         


Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp 
        115                 120                 125             


Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp 
    130                 135                 140                 


Leu Xaa Glu Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser Ser His Asp 
145                 150                 155                 160 


Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Xaa Asp 
                165                 170                 175     


Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp 
            180                 185                 190         


Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Xaa Asn Xaa Ala 
        195                 200                 205             


Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys 
    210                 215                 220                 


Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln 
225                 230                 235                 240 


Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys 
                245                 250                 255     


Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro 
            260                 265                 270         


Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Xaa 
        275                 280                 285             


Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys 
    290                 295                 300                 


Lys Pro Ile Glu Asp Pro Ala Asn Asp Xaa Val Asp Phe Pro Lys Arg 
305                 310                 315                 320 


Xaa Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val 
                325                 330                 335     


Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Xaa Pro Ala Ile Leu 
            340                 345                 350         


Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Xaa 
        355                 360                 365             


Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser 
    370                 375                 380                 


Ala Ile Ala Asp Leu Leu Xaa Asn Glu His Glu Arg Val Val Lys Ala 
385                 390                 395                 400 


Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu 
                405                 410                 415     


Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly 
            420                 425                 430         


Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Xaa Val Ile Ser 
        435                 440                 445             


Ile Leu Asn Xaa Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala 
    450                 455                 460                 


Lys Lys Leu Arg Glu Xaa Gln Gly Ile Glu Lys Leu Val Leu Ile Asn 
465                 470                 475                 480 


Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val 
                485                 490                 495     


Leu Gln Xaa Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys 
            500                 505                 510         


Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser 
        515                 520                 525             


Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Xaa Leu Pro Leu Ile 
    530                 535                 540                 


Asp Arg Asn Gln Lys Ser Asp Asn Asn Tyr Ser Xaa Pro Asn Glu Arg 
545                 550                 555                 560 


Gly Asp His Asn Arg Xaa Leu Asp Arg Ser Gly Asp Leu Gly Asp Met 
                565                 570                 575     


Glu Pro Leu Lys Gly Xaa Xaa Pro Leu Met Gln Asp Glu Gly Gln Glu 
            580                 585                 590         


Ser Leu Glu Glu Glu Leu Asp Val Leu Val Leu Asp Asp Glu Gly Gly 
        595                 600                 605             


Gln Val Ser Tyr Pro Ser Met Gln Lys Ile 
    610                 615             


<210> 7267
<211> 639
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(604)
<223> Selenocysteine

<400> 7267
Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu 
1               5                   10                  15      


Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys 
            20                  25                  30          


Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val 
        35                  40                  45              


Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala 
    50                  55                  60                  


Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Xaa Asp 
65                  70                  75                  80  


Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His 
                85                  90                  95      


Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile 
            100                 105                 110         


Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp 
        115                 120                 125             


Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp 
    130                 135                 140                 


Leu Xaa Glu Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser Ser His Asp 
145                 150                 155                 160 


Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Xaa Asp 
                165                 170                 175     


Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp 
            180                 185                 190         


Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Xaa Asn Xaa Ala 
        195                 200                 205             


Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys 
    210                 215                 220                 


Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln 
225                 230                 235                 240 


Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys 
                245                 250                 255     


Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro 
            260                 265                 270         


Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Xaa 
        275                 280                 285             


Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys 
    290                 295                 300                 


Lys Pro Ile Glu Asp Pro Ala Asn Asp Xaa Val Asp Phe Pro Lys Arg 
305                 310                 315                 320 


Xaa Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val 
                325                 330                 335     


Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Xaa Pro Ala Ile Leu 
            340                 345                 350         


Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Xaa 
        355                 360                 365             


Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser 
    370                 375                 380                 


Ala Ile Ala Asp Leu Leu Xaa Asn Glu His Glu Arg Val Val Lys Ala 
385                 390                 395                 400 


Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu 
                405                 410                 415     


Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly 
            420                 425                 430         


Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Xaa Val Ile Ser 
        435                 440                 445             


Ile Leu Asn Xaa Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala 
    450                 455                 460                 


Lys Lys Leu Arg Glu Xaa Gln Gly Ile Glu Lys Leu Val Leu Ile Asn 
465                 470                 475                 480 


Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val 
                485                 490                 495     


Leu Gln Xaa Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys 
            500                 505                 510         


Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser 
        515                 520                 525             


Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Xaa Leu Pro Leu Ile 
    530                 535                 540                 


Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu Glu Ile Gln 
545                 550                 555                 560 


Met Ser Asn Met Gly Ser Asn Xaa Lys Ser Leu Asp Asn Asn Tyr Ser 
                565                 570                 575     


Xaa Pro Asn Glu Arg Gly Asp His Asn Arg Xaa Leu Asp Arg Ser Gly 
            580                 585                 590         


Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Xaa Xaa Pro Leu Met Gln 
        595                 600                 605             


Asp Glu Gly Gln Glu Ser Leu Glu Glu Glu Leu Asp Val Leu Val Leu 
    610                 615                 620                 


Asp Asp Glu Gly Gly Gln Val Ser Tyr Pro Ser Met Gln Lys Ile 
625                 630                 635                 


<210> 7268
<211> 645
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(610)
<223> Selenocysteine

<400> 7268
Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu 
1               5                   10                  15      


Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys 
            20                  25                  30          


Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val 
        35                  40                  45              


Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala 
    50                  55                  60                  


Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Xaa Asp 
65                  70                  75                  80  


Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His 
                85                  90                  95      


Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile 
            100                 105                 110         


Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp 
        115                 120                 125             


Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp 
    130                 135                 140                 


Leu Xaa Glu Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser Ser His Asp 
145                 150                 155                 160 


Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Xaa Asp 
                165                 170                 175     


Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp 
            180                 185                 190         


Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Xaa Asn Xaa Ala 
        195                 200                 205             


Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys 
    210                 215                 220                 


Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln 
225                 230                 235                 240 


Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys 
                245                 250                 255     


Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro 
            260                 265                 270         


Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Xaa 
        275                 280                 285             


Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Asp Glu 
    290                 295                 300                 


Trp Phe Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Xaa 
305                 310                 315                 320 


Val Asp Phe Pro Lys Arg Xaa Ser Pro Ala Arg Gly Tyr Glu Leu Leu 
                325                 330                 335     


Phe Gln Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser 
            340                 345                 350         


Lys Xaa Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu 
        355                 360                 365             


Cys Ala Gly Arg Trp Xaa Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg 
    370                 375                 380                 


Gln Glu Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Xaa Asn Glu His 
385                 390                 395                 400 


Glu Arg Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val 
                405                 410                 415     


Asp Ala Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu 
            420                 425                 430         


Val Lys Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser 
        435                 440                 445             


Glu Asp Xaa Val Ile Ser Ile Leu Asn Xaa Ile Asn Glu Val Ile Ala 
    450                 455                 460                 


Glu Asn Leu Glu Ala Ala Lys Lys Leu Arg Glu Xaa Gln Gly Ile Glu 
465                 470                 475                 480 


Lys Leu Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val 
                485                 490                 495     


Arg Ala Ala Ala Leu Val Leu Gln Xaa Ile Trp Gly Tyr Lys Glu Leu 
            500                 505                 510         


Arg Lys Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val 
        515                 520                 525             


Asn Leu Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp 
    530                 535                 540                 


Ser Xaa Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro 
545                 550                 555                 560 


Asp Arg Glu Glu Ile Gln Met Ser Asn Met Gly Ser Asn Xaa Lys Ser 
                565                 570                 575     


Leu Asp Asn Asn Tyr Ser Xaa Pro Asn Glu Arg Gly Asp His Asn Arg 
            580                 585                 590         


Xaa Leu Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly 
        595                 600                 605             


Xaa Xaa Pro Leu Met Gln Asp Glu Gly Gln Glu Ser Leu Glu Glu Glu 
    610                 615                 620                 


Leu Asp Val Leu Val Leu Asp Asp Glu Gly Gly Gln Val Ser Tyr Pro 
625                 630                 635                 640 


Ser Met Gln Lys Ile 
                645 


<210> 7269
<211> 832
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(826)
<223> Selenocysteine

<400> 7269
Met Gln Glu Pro Gly Gln Ile Val Glu Xaa Tyr Xaa Glu Glu Asp Pro 
1               5                   10                  15      


Glu Gly Ala Met Ser Val Val Ser Val Glu Xaa Ser Asp Asp Gly Xaa 
            20                  25                  30          


Xaa Arg Arg Xaa Glu Xaa Xaa Val Lys Lys Val Val Lys Xaa Val Xaa 
        35                  40                  45              


Xaa Arg Xaa Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val 
    50                  55                  60                  


Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Xaa Leu Gly Arg Asp 
65                  70                  75                  80  


Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala 
                85                  90                  95      


Gly Xaa Ala Xaa Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr 
            100                 105                 110         


Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly 
        115                 120                 125             


Ser Leu Ser Arg Val Xaa Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met 
    130                 135                 140                 


Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro 
145                 150                 155                 160 


Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro 
                165                 170                 175     


Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp 
            180                 185                 190         


Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Xaa Ala Arg Arg Xaa Gly 
        195                 200                 205             


Xaa Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile 
    210                 215                 220                 


Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln 
225                 230                 235                 240 


His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly 
                245                 250                 255     


Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala 
            260                 265                 270         


Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr 
        275                 280                 285             


Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Xaa Asp Val Arg 
    290                 295                 300                 


Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys 
305                 310                 315                 320 


Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe 
                325                 330                 335     


Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val 
            340                 345                 350         


Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Xaa 
        355                 360                 365             


Glu Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser Ser His Asp Ser Ile 
    370                 375                 380                 


Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Xaa Asp Glu Val 
385                 390                 395                 400 


Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys 
                405                 410                 415     


Pro Arg His Ile Glu Trp Glu Ser Val Leu Xaa Asn Xaa Ala Gly Cys 
            420                 425                 430         


Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg 
        435                 440                 445             


Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu 
    450                 455                 460                 


Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys 
465                 470                 475                 480 


Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala 
                485                 490                 495     


Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Xaa Gly Pro 
            500                 505                 510         


His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys Lys Pro 
        515                 520                 525             


Ile Glu Asp Pro Ala Asn Asp Xaa Val Asp Phe Pro Lys Arg Xaa Ser 
    530                 535                 540                 


Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile 
545                 550                 555                 560 


Tyr Ile Ser Leu Leu Lys Glu Ser Lys Xaa Pro Ala Ile Leu Glu Ala 
                565                 570                 575     


Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Xaa Tyr Gly 
            580                 585                 590         


Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile 
        595                 600                 605             


Ala Asp Leu Leu Xaa Asn Glu His Glu Arg Val Val Lys Ala Ala Ser 
    610                 615                 620                 


Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile 
625                 630                 635                 640 


Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln 
                645                 650                 655     


Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Xaa Val Ile Ser Ile Leu 
            660                 665                 670         


Asn Xaa Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys 
        675                 680                 685             


Leu Arg Glu Xaa Gln Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser 
    690                 695                 700                 


Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln 
705                 710                 715                 720 


Xaa Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly 
                725                 730                 735     


Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser 
            740                 745                 750         


Gln Ser Ser His Ser Tyr Asp Asp Ser Xaa Leu Pro Leu Ile Asp Arg 
        755                 760                 765             


Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu Glu Ile Gln Met Ser 
    770                 775                 780                 


Asn Met Gly Ser Asn Xaa Lys Ser Leu Asp Asn Asn Tyr Ser Xaa Pro 
785                 790                 795                 800 


Asn Glu Arg Gly Asp His Asn Arg Xaa Leu Asp Arg Ser Gly Asp Leu 
                805                 810                 815     


Gly Asp Met Glu Pro Leu Lys Gly Xaa Xaa Pro Leu Met Gln Lys Ile 
            820                 825                 830         


<210> 7270
<211> 838
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(832)
<223> Selenocysteine

<400> 7270
Met Gln Glu Pro Gly Gln Ile Val Glu Xaa Tyr Xaa Glu Glu Asp Pro 
1               5                   10                  15      


Glu Gly Ala Met Ser Val Val Ser Val Glu Xaa Ser Asp Asp Gly Xaa 
            20                  25                  30          


Xaa Arg Arg Xaa Glu Xaa Xaa Val Lys Lys Val Val Lys Xaa Val Xaa 
        35                  40                  45              


Xaa Arg Xaa Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val 
    50                  55                  60                  


Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Xaa Leu Gly Arg Asp 
65                  70                  75                  80  


Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala 
                85                  90                  95      


Gly Xaa Ala Xaa Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr 
            100                 105                 110         


Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly 
        115                 120                 125             


Ser Leu Ser Arg Val Xaa Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met 
    130                 135                 140                 


Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro 
145                 150                 155                 160 


Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro 
                165                 170                 175     


Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp 
            180                 185                 190         


Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Xaa Ala Arg Arg Xaa Gly 
        195                 200                 205             


Xaa Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile 
    210                 215                 220                 


Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln 
225                 230                 235                 240 


His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly 
                245                 250                 255     


Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala 
            260                 265                 270         


Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr 
        275                 280                 285             


Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Xaa Asp Val Arg 
    290                 295                 300                 


Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys 
305                 310                 315                 320 


Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe 
                325                 330                 335     


Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val 
            340                 345                 350         


Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Xaa 
        355                 360                 365             


Glu Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser Ser His Asp Ser Ile 
    370                 375                 380                 


Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Xaa Asp Glu Val 
385                 390                 395                 400 


Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys 
                405                 410                 415     


Pro Arg His Ile Glu Trp Glu Ser Val Leu Xaa Asn Xaa Ala Gly Cys 
            420                 425                 430         


Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg 
        435                 440                 445             


Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu 
    450                 455                 460                 


Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys 
465                 470                 475                 480 


Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala 
                485                 490                 495     


Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Xaa Gly Pro 
            500                 505                 510         


His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Asp Glu Trp Phe 
        515                 520                 525             


Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Xaa Val Asp 
    530                 535                 540                 


Phe Pro Lys Arg Xaa Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln 
545                 550                 555                 560 


Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Xaa 
                565                 570                 575     


Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala 
            580                 585                 590         


Gly Arg Trp Xaa Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu 
        595                 600                 605             


Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Xaa Asn Glu His Glu Arg 
    610                 615                 620                 


Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala 
625                 630                 635                 640 


Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys 
                645                 650                 655     


Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp 
            660                 665                 670         


Xaa Val Ile Ser Ile Leu Asn Xaa Ile Asn Glu Val Ile Ala Glu Asn 
        675                 680                 685             


Leu Glu Ala Ala Lys Lys Leu Arg Glu Xaa Gln Gly Ile Glu Lys Leu 
    690                 695                 700                 


Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala 
705                 710                 715                 720 


Ala Ala Leu Val Leu Gln Xaa Ile Trp Gly Tyr Lys Glu Leu Arg Lys 
                725                 730                 735     


Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu 
            740                 745                 750         


Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Xaa 
        755                 760                 765             


Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg 
    770                 775                 780                 


Glu Glu Ile Gln Met Ser Asn Met Gly Ser Asn Xaa Lys Ser Leu Asp 
785                 790                 795                 800 


Asn Asn Tyr Ser Xaa Pro Asn Glu Arg Gly Asp His Asn Arg Xaa Leu 
                805                 810                 815     


Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Xaa Xaa 
            820                 825                 830         


Pro Leu Met Gln Lys Ile 
        835             


<210> 7271
<211> 840
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (788)..(788)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (804)..(805)
<223> Selenocysteine

<400> 7271
Met Gln Glu Pro Gly Gln Ile Val Glu Xaa Tyr Xaa Glu Glu Asp Pro 
1               5                   10                  15      


Glu Gly Ala Met Ser Val Val Ser Val Glu Xaa Ser Asp Asp Gly Xaa 
            20                  25                  30          


Xaa Arg Arg Xaa Glu Xaa Xaa Val Lys Lys Val Val Lys Xaa Val Xaa 
        35                  40                  45              


Xaa Arg Xaa Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val 
    50                  55                  60                  


Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Xaa Leu Gly Arg Asp 
65                  70                  75                  80  


Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala 
                85                  90                  95      


Gly Xaa Ala Xaa Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr 
            100                 105                 110         


Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly 
        115                 120                 125             


Ser Leu Ser Arg Val Xaa Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met 
    130                 135                 140                 


Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro 
145                 150                 155                 160 


Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro 
                165                 170                 175     


Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp 
            180                 185                 190         


Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Xaa Ala Arg Arg Xaa Gly 
        195                 200                 205             


Xaa Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile 
    210                 215                 220                 


Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln 
225                 230                 235                 240 


His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly 
                245                 250                 255     


Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala 
            260                 265                 270         


Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr 
        275                 280                 285             


Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Xaa Asp Val Arg 
    290                 295                 300                 


Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys 
305                 310                 315                 320 


Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe 
                325                 330                 335     


Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val 
            340                 345                 350         


Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Xaa 
        355                 360                 365             


Glu Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser Ser His Asp Ser Ile 
    370                 375                 380                 


Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Xaa Asp Glu Val 
385                 390                 395                 400 


Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys 
                405                 410                 415     


Pro Arg His Ile Glu Trp Glu Ser Val Leu Xaa Asn Xaa Ala Gly Cys 
            420                 425                 430         


Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg 
        435                 440                 445             


Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu 
    450                 455                 460                 


Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys 
465                 470                 475                 480 


Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala 
                485                 490                 495     


Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Xaa Gly Pro 
            500                 505                 510         


His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys Lys Pro 
        515                 520                 525             


Ile Glu Asp Pro Ala Asn Asp Xaa Val Asp Phe Pro Lys Arg Xaa Ser 
    530                 535                 540                 


Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile 
545                 550                 555                 560 


Tyr Ile Ser Leu Leu Lys Glu Ser Lys Xaa Pro Ala Ile Leu Glu Ala 
                565                 570                 575     


Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Xaa Tyr Gly 
            580                 585                 590         


Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile 
        595                 600                 605             


Ala Asp Leu Leu Xaa Asn Glu His Glu Arg Val Val Lys Ala Ala Ser 
    610                 615                 620                 


Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile 
625                 630                 635                 640 


Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln 
                645                 650                 655     


Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Xaa Val Ile Ser Ile Leu 
            660                 665                 670         


Asn Xaa Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys 
        675                 680                 685             


Leu Arg Glu Xaa Gln Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser 
    690                 695                 700                 


Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln 
705                 710                 715                 720 


Xaa Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly 
                725                 730                 735     


Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser 
            740                 745                 750         


Gln Ser Ser His Ser Tyr Asp Asp Ser Xaa Leu Pro Leu Ile Asp Arg 
        755                 760                 765             


Asn Gln Lys Ser Asp Asn Asn Tyr Ser Xaa Pro Asn Glu Arg Gly Asp 
    770                 775                 780                 


His Asn Arg Xaa Leu Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro 
785                 790                 795                 800 


Leu Lys Gly Xaa Xaa Pro Leu Met Gln Asp Glu Gly Gln Glu Ser Leu 
                805                 810                 815     


Glu Glu Glu Leu Asp Val Leu Val Leu Asp Asp Glu Gly Gly Gln Val 
            820                 825                 830         


Ser Tyr Pro Ser Met Gln Lys Ile 
        835                 840 


<210> 7272
<211> 861
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(826)
<223> Selenocysteine

<400> 7272
Met Gln Glu Pro Gly Gln Ile Val Glu Xaa Tyr Xaa Glu Glu Asp Pro 
1               5                   10                  15      


Glu Gly Ala Met Ser Val Val Ser Val Glu Xaa Ser Asp Asp Gly Xaa 
            20                  25                  30          


Xaa Arg Arg Xaa Glu Xaa Xaa Val Lys Lys Val Val Lys Xaa Val Xaa 
        35                  40                  45              


Xaa Arg Xaa Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val 
    50                  55                  60                  


Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Xaa Leu Gly Arg Asp 
65                  70                  75                  80  


Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala 
                85                  90                  95      


Gly Xaa Ala Xaa Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr 
            100                 105                 110         


Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly 
        115                 120                 125             


Ser Leu Ser Arg Val Xaa Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met 
    130                 135                 140                 


Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro 
145                 150                 155                 160 


Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro 
                165                 170                 175     


Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp 
            180                 185                 190         


Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Xaa Ala Arg Arg Xaa Gly 
        195                 200                 205             


Xaa Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile 
    210                 215                 220                 


Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln 
225                 230                 235                 240 


His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly 
                245                 250                 255     


Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala 
            260                 265                 270         


Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr 
        275                 280                 285             


Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Xaa Asp Val Arg 
    290                 295                 300                 


Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys 
305                 310                 315                 320 


Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe 
                325                 330                 335     


Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val 
            340                 345                 350         


Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Xaa 
        355                 360                 365             


Glu Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser Ser His Asp Ser Ile 
    370                 375                 380                 


Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Xaa Asp Glu Val 
385                 390                 395                 400 


Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys 
                405                 410                 415     


Pro Arg His Ile Glu Trp Glu Ser Val Leu Xaa Asn Xaa Ala Gly Cys 
            420                 425                 430         


Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg 
        435                 440                 445             


Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu 
    450                 455                 460                 


Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys 
465                 470                 475                 480 


Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala 
                485                 490                 495     


Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Xaa Gly Pro 
            500                 505                 510         


His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys Lys Pro 
        515                 520                 525             


Ile Glu Asp Pro Ala Asn Asp Xaa Val Asp Phe Pro Lys Arg Xaa Ser 
    530                 535                 540                 


Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile 
545                 550                 555                 560 


Tyr Ile Ser Leu Leu Lys Glu Ser Lys Xaa Pro Ala Ile Leu Glu Ala 
                565                 570                 575     


Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Xaa Tyr Gly 
            580                 585                 590         


Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile 
        595                 600                 605             


Ala Asp Leu Leu Xaa Asn Glu His Glu Arg Val Val Lys Ala Ala Ser 
    610                 615                 620                 


Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile 
625                 630                 635                 640 


Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln 
                645                 650                 655     


Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Xaa Val Ile Ser Ile Leu 
            660                 665                 670         


Asn Xaa Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys 
        675                 680                 685             


Leu Arg Glu Xaa Gln Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser 
    690                 695                 700                 


Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln 
705                 710                 715                 720 


Xaa Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly 
                725                 730                 735     


Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser 
            740                 745                 750         


Gln Ser Ser His Ser Tyr Asp Asp Ser Xaa Leu Pro Leu Ile Asp Arg 
        755                 760                 765             


Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu Glu Ile Gln Met Ser 
    770                 775                 780                 


Asn Met Gly Ser Asn Xaa Lys Ser Leu Asp Asn Asn Tyr Ser Xaa Pro 
785                 790                 795                 800 


Asn Glu Arg Gly Asp His Asn Arg Xaa Leu Asp Arg Ser Gly Asp Leu 
                805                 810                 815     


Gly Asp Met Glu Pro Leu Lys Gly Xaa Xaa Pro Leu Met Gln Asp Glu 
            820                 825                 830         


Gly Gln Glu Ser Leu Glu Glu Glu Leu Asp Val Leu Val Leu Asp Asp 
        835                 840                 845             


Glu Gly Gly Gln Val Ser Tyr Pro Ser Met Gln Lys Ile 
    850                 855                 860     


<210> 7273
<211> 867
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (542)..(542)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (805)..(805)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (815)..(815)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (831)..(832)
<223> Selenocysteine

<400> 7273
Met Gln Glu Pro Gly Gln Ile Val Glu Xaa Tyr Xaa Glu Glu Asp Pro 
1               5                   10                  15      


Glu Gly Ala Met Ser Val Val Ser Val Glu Xaa Ser Asp Asp Gly Xaa 
            20                  25                  30          


Xaa Arg Arg Xaa Glu Xaa Xaa Val Lys Lys Val Val Lys Xaa Val Xaa 
        35                  40                  45              


Xaa Arg Xaa Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val 
    50                  55                  60                  


Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Xaa Leu Gly Arg Asp 
65                  70                  75                  80  


Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala 
                85                  90                  95      


Gly Xaa Ala Xaa Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr 
            100                 105                 110         


Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly 
        115                 120                 125             


Ser Leu Ser Arg Val Xaa Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met 
    130                 135                 140                 


Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro 
145                 150                 155                 160 


Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro 
                165                 170                 175     


Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp 
            180                 185                 190         


Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Xaa Ala Arg Arg Xaa Gly 
        195                 200                 205             


Xaa Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile 
    210                 215                 220                 


Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln 
225                 230                 235                 240 


His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly 
                245                 250                 255     


Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala 
            260                 265                 270         


Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr 
        275                 280                 285             


Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Xaa Asp Val Arg 
    290                 295                 300                 


Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys 
305                 310                 315                 320 


Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe 
                325                 330                 335     


Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val 
            340                 345                 350         


Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Xaa 
        355                 360                 365             


Glu Val Ile Xaa Gly Xaa Leu Trp Asn Leu Ser Ser His Asp Ser Ile 
    370                 375                 380                 


Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Xaa Asp Glu Val 
385                 390                 395                 400 


Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys 
                405                 410                 415     


Pro Arg His Ile Glu Trp Glu Ser Val Leu Xaa Asn Xaa Ala Gly Cys 
            420                 425                 430         


Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg 
        435                 440                 445             


Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu 
    450                 455                 460                 


Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys 
465                 470                 475                 480 


Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala 
                485                 490                 495     


Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Xaa Gly Pro 
            500                 505                 510         


His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Asp Glu Trp Phe 
        515                 520                 525             


Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Xaa Val Asp 
    530                 535                 540                 


Phe Pro Lys Arg Xaa Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln 
545                 550                 555                 560 


Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Xaa 
                565                 570                 575     


Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala 
            580                 585                 590         


Gly Arg Trp Xaa Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu 
        595                 600                 605             


Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Xaa Asn Glu His Glu Arg 
    610                 615                 620                 


Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala 
625                 630                 635                 640 


Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys 
                645                 650                 655     


Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp 
            660                 665                 670         


Xaa Val Ile Ser Ile Leu Asn Xaa Ile Asn Glu Val Ile Ala Glu Asn 
        675                 680                 685             


Leu Glu Ala Ala Lys Lys Leu Arg Glu Xaa Gln Gly Ile Glu Lys Leu 
    690                 695                 700                 


Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala 
705                 710                 715                 720 


Ala Ala Leu Val Leu Gln Xaa Ile Trp Gly Tyr Lys Glu Leu Arg Lys 
                725                 730                 735     


Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu 
            740                 745                 750         


Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Xaa 
        755                 760                 765             


Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg 
    770                 775                 780                 


Glu Glu Ile Gln Met Ser Asn Met Gly Ser Asn Xaa Lys Ser Leu Asp 
785                 790                 795                 800 


Asn Asn Tyr Ser Xaa Pro Asn Glu Arg Gly Asp His Asn Arg Xaa Leu 
                805                 810                 815     


Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Xaa Xaa 
            820                 825                 830         


Pro Leu Met Gln Asp Glu Gly Gln Glu Ser Leu Glu Glu Glu Leu Asp 
        835                 840                 845             


Val Leu Val Leu Asp Asp Glu Gly Gly Gln Val Ser Tyr Pro Ser Met 
    850                 855                 860                 


Gln Lys Ile 
865         


<210> 7274
<211> 123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(110)
<223> Selenocysteine

<400> 7274
Xaa Val Leu Gln Xaa Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu 
1               5                   10                  15      


Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn 
            20                  25                  30          


Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Xaa Leu Pro 
        35                  40                  45              


Leu Ile Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu Glu 
    50                  55                  60                  


Ile Gln Met Ser Asn Met Gly Ser Asn Xaa Lys Ser Leu Asp Asn Asn 
65                  70                  75                  80  


Tyr Ser Xaa Pro Asn Glu Arg Gly Asp His Asn Arg Xaa Leu Asp Arg 
                85                  90                  95      


Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Xaa Xaa Pro Leu 
            100                 105                 110         


Met Val Asn Ser Leu Tyr Ile Leu Leu Ser Val 
        115                 120             


<210> 7275
<211> 1225
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1093)..(1093)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1107)..(1107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1156)..(1156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1164)..(1164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1214)..(1214)
<223> Selenocysteine

<400> 7275
Met Phe Ala Arg Lys Pro Pro Gly Ala Ala Pro Leu Gly Ala Met Pro 
1               5                   10                  15      


Val Pro Asp Gln Pro Ser Ser Ala Ser Glu Lys Xaa Ser Ser Leu Ser 
            20                  25                  30          


Pro Gly Leu Asn Xaa Ser Asn Gly Asp Gly Ser Glu Xaa Glu Xaa Xaa 
        35                  40                  45              


Ser Ala Ile Leu Ala Ser Val Lys Glu Gln Glu Leu Gln Phe Glu Arg 
    50                  55                  60                  


Leu Xaa Arg Glu Leu Glu Ala Glu Arg Gln Ile Val Ala Ser Gln Leu 
65                  70                  75                  80  


Glu Arg Cys Lys Leu Gly Ser Glu Xaa Gly Ser Met Ser Ser Met Ser 
                85                  90                  95      


Ser Ala Glu Glu Gln Phe Gln Trp Gln Ser Gln Asp Gly Gln Lys Asp 
            100                 105                 110         


Ile Glu Asp Glu Leu Xaa Xaa Gly Leu Glu Leu Val Asp Ser Cys Ile 
        115                 120                 125             


Arg Ser Leu Gln Glu Ser Gly Ile Leu Asp Pro Gln Asp Tyr Ser Xaa 
    130                 135                 140                 


Gly Glu Arg Pro Ser Leu Leu Ser Gln Ser Ala Leu Gln Leu Asn Ser 
145                 150                 155                 160 


Lys Pro Glu Gly Ser Phe Gln Tyr Pro Ala Ser Tyr His Ser Asn Gln 
                165                 170                 175     


Xaa Leu Ala Leu Gly Glu Xaa Xaa Pro Ser Gln Leu Pro Ala Arg Gly 
            180                 185                 190         


Xaa Gln Ala Arg Ala Xaa Gly Gln Ser Phe Ser Gln Gly Xaa Xaa Ser 
        195                 200                 205             


Arg Ala Gly His Leu Ala Gly Pro Glu Pro Ala Pro Pro Pro Pro Pro 
    210                 215                 220                 


Pro Pro Arg Glu Pro Phe Ala Pro Ser Leu Gly Ser Ala Phe His Leu 
225                 230                 235                 240 


Pro Asp Ala Pro Pro Ala Ala Ala Ala Ala Ala Leu Tyr Tyr Ser Ser 
                245                 250                 255     


Ser Xaa Leu Pro Ala Pro Pro Arg Gly Gly Ser Pro Leu Ala Ala Pro 
            260                 265                 270         


Gln Gly Gly Ser Pro Xaa Lys Leu Gln Arg Gly Gly Ser Ala Pro Glu 
        275                 280                 285             


Gly Ala Xaa Tyr Ala Ala Pro Arg Gly Ser Ser Pro Lys Gln Ser Pro 
    290                 295                 300                 


Ser Arg Leu Ala Lys Ser Tyr Ser Xaa Ser Ser Pro Ile Asn Ile Val 
305                 310                 315                 320 


Val Ser Ser Ala Gly Leu Ser Pro Ile Arg Val Xaa Ser Pro Pro Xaa 
                325                 330                 335     


Val Gln Ser Xaa Ile Ser Ser Ser Pro Ile His Gln Leu Ser Ser Xaa 
            340                 345                 350         


Ile Gly Xaa Tyr Ala Xaa Leu Ser Pro Xaa Lys Arg Leu Val His Ala 
        355                 360                 365             


Ser Glu Gln Tyr Ser Lys His Ser Gln Glu Leu Tyr Ala Xaa Ala Xaa 
    370                 375                 380                 


Leu Gln Arg Pro Gly Ser Leu Ala Ala Gly Ser Arg Ala Ser Tyr Ser 
385                 390                 395                 400 


Ser Gln His Gly His Leu Gly Pro Glu Leu Arg Ala Leu Gln Ser Pro 
                405                 410                 415     


Glu His His Ile Asp Pro Ile Tyr Glu Asp Arg Val Tyr Gln Lys Pro 
            420                 425                 430         


Pro Met Arg Ser Leu Ser Gln Ser Gln Gly Asp Pro Leu Pro Pro Ala 
        435                 440                 445             


His Xaa Gly Xaa Tyr Arg Xaa Ser Xaa Ala Pro Ser Ser Pro Gly Val 
    450                 455                 460                 


Asp Ser Val Pro Leu Gln Arg Xaa Gly Ser Gln His Gly Pro Gln Asn 
465                 470                 475                 480 


Ala Ala Ala Ala Xaa Phe Gln Arg Ala Ser Tyr Ala Ala Gly Pro Ala 
                485                 490                 495     


Ser Asn Tyr Ala Asp Pro Tyr Arg Gln Leu Gln Tyr Cys Pro Ser Val 
            500                 505                 510         


Glu Ser Pro Tyr Ser Lys Ser Gly Pro Ala Leu Pro Pro Glu Gly Xaa 
        515                 520                 525             


Leu Ala Arg Ser Pro Ser Ile Asp Ser Ile Gln Lys Asp Pro Arg Glu 
    530                 535                 540                 


Phe Gly Trp Arg Asp Pro Glu Leu Pro Glu Val Ile Gln Met Leu Gln 
545                 550                 555                 560 


His Gln Phe Pro Ser Val Gln Ser Asn Ala Ala Ala Tyr Leu Gln His 
                565                 570                 575     


Leu Cys Phe Gly Asp Asn Lys Ile Lys Ala Glu Ile Arg Arg Gln Gly 
            580                 585                 590         


Gly Ile Gln Leu Leu Val Asp Leu Leu Asp His Arg Met Xaa Glu Val 
        595                 600                 605             


His Arg Ser Ala Cys Gly Ala Leu Arg Asn Leu Val Tyr Gly Lys Ala 
    610                 615                 620                 


Asn Asp Asp Asn Lys Ile Ala Leu Lys Asn Cys Gly Gly Ile Pro Ala 
625                 630                 635                 640 


Leu Val Arg Leu Leu Arg Lys Xaa Xaa Asp Leu Glu Ile Arg Glu Leu 
                645                 650                 655     


Val Xaa Gly Val Leu Trp Asn Leu Ser Ser Cys Asp Ala Leu Lys Met 
            660                 665                 670         


Pro Ile Ile Gln Asp Ala Leu Ala Val Leu Xaa Asn Ala Val Ile Ile 
        675                 680                 685             


Pro His Ser Gly Trp Glu Asn Ser Pro Leu Gln Asp Asp Arg Lys Ile 
    690                 695                 700                 


Gln Leu His Ser Ser Gln Val Leu Arg Asn Ala Xaa Gly Cys Leu Arg 
705                 710                 715                 720 


Asn Val Ser Ser Ala Gly Glu Glu Ala Arg Arg Arg Met Arg Glu Cys 
                725                 730                 735     


Asp Gly Leu Xaa Asp Ala Leu Leu Tyr Val Ile Gln Ser Ala Leu Gly 
            740                 745                 750         


Ser Ser Glu Ile Asp Ser Lys Xaa Val Glu Asn Cys Val Cys Ile Leu 
        755                 760                 765             


Arg Asn Leu Ser Tyr Arg Leu Ala Ala Glu Xaa Ser Gln Gly Gln His 
    770                 775                 780                 


Met Gly Xaa Asp Glu Leu Asp Gly Leu Leu Cys Gly Glu Ala Asn Gly 
785                 790                 795                 800 


Lys Asp Ala Glu Ser Ser Gly Cys Trp Gly Lys Lys Lys Lys Lys Lys 
                805                 810                 815     


Lys Ser Gln Asp Gln Trp Asp Gly Val Gly Pro Leu Pro Asp Cys Ala 
            820                 825                 830         


Glu Pro Pro Lys Gly Ile Gln Met Leu Trp His Pro Ser Ile Val Lys 
        835                 840                 845             


Pro Tyr Leu Xaa Leu Leu Ser Glu Cys Ser Asn Pro Asp Xaa Leu Glu 
    850                 855                 860                 


Gly Ala Ala Gly Ala Leu Gln Asn Leu Ala Ala Gly Ser Trp Lys Trp 
865                 870                 875                 880 


Ser Val Tyr Ile Arg Ala Ala Val Arg Lys Glu Lys Gly Leu Pro Ile 
                885                 890                 895     


Leu Val Glu Leu Leu Arg Ile Asp Asn Asp Arg Val Val Cys Ala Val 
            900                 905                 910         


Ala Xaa Ala Leu Arg Asn Met Ala Leu Asp Val Arg Asn Lys Glu Leu 
        915                 920                 925             


Ile Gly Lys Tyr Ala Met Arg Asp Leu Val His Arg Leu Pro Gly Gly 
    930                 935                 940                 


Asn Asn Ser Asn Asn Xaa Ala Ser Lys Ala Met Ser Asp Asp Xaa Val 
945                 950                 955                 960 


Xaa Ala Val Cys Cys Xaa Leu His Glu Val Ile Xaa Lys Asn Met Glu 
                965                 970                 975     


Asn Ala Lys Ala Leu Arg Asp Ala Gly Gly Ile Glu Lys Leu Val Gly 
            980                 985                 990         


Ile Ser Lys Ser Lys Gly Asp Lys  His Ser Pro Lys Val  Val Lys Ala 
        995                 1000                 1005             


Ala Ser  Gln Val Leu Asn Ser  Met Trp Gln Tyr Arg  Asp Leu Arg 
    1010                 1015                 1020             


Ser Leu  Tyr Lys Lys Asp Gly  Trp Ser Gln Tyr His  Phe Val Ala 
    1025                 1030                 1035             


Ser Ser  Ser Xaa Ile Glu Arg  Asp Arg Gln Arg Pro  Tyr Ser Ser 
    1040                 1045                 1050             


Ser Arg  Xaa Pro Ser Ile Ser  Pro Val Arg Val Ser  Pro Asn Asn 
    1055                 1060                 1065             


Arg Ser  Ala Ser Ala Pro Ala  Ser Pro Arg Glu Met  Ile Ser Leu 
    1070                 1075                 1080             


Lys Glu  Arg Lys Xaa Asp Tyr  Glu Cys Xaa Gly Ser  Asn Ala Xaa 
    1085                 1090                 1095             


Tyr His  Gly Ala Lys Gly Glu  His Xaa Ser Arg Lys  Asp Ala Met 
    1100                 1105                 1110             


Xaa Ala  Gln Asn Xaa Gly Ile  Ser Xaa Leu Tyr Arg  Asn Ser Tyr 
    1115                 1120                 1125             


Gly Ala  Pro Ala Glu Asp Ile  Lys His Asn Gln Val  Ser Ala Gln 
    1130                 1135                 1140             


Pro Val  Pro Gln Glu Pro Ser  Arg Lys Asp Tyr Glu  Xaa Tyr Gln 
    1145                 1150                 1155             


Pro Phe  Gln Asn Ser Xaa Arg  Asn Tyr Asp Glu Ser  Phe Phe Glu 
    1160                 1165                 1170             


Asp Gln  Val His His Arg Pro  Pro Ala Ser Glu Tyr  Xaa Met His 
    1175                 1180                 1185             


Leu Gly  Leu Lys Ser Xaa Gly  Asn Tyr Val Asp Phe  Tyr Ser Ala 
    1190                 1195                 1200             


Ala Arg  Pro Tyr Ser Glu Leu  Asn Tyr Glu Xaa Ser  His Tyr Pro 
    1205                 1210                 1215             


Ala Ser  Pro Asp Ser Trp Val  
    1220                 1225 


<210> 7276
<211> 231
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(231)
<223> Selenocysteine

<400> 7276
Met Phe Ala Arg Lys Pro Pro Gly Ala Ala Pro Leu Gly Ala Met Pro 
1               5                   10                  15      


Val Pro Asp Gln Pro Ser Ser Ala Ser Glu Lys Xaa Ser Ser Leu Ser 
            20                  25                  30          


Pro Gly Leu Asn Xaa Ser Asn Gly Asp Gly Ser Glu Xaa Glu Xaa Xaa 
        35                  40                  45              


Ser Ala Ile Leu Ala Ser Val Lys Glu Gln Glu Leu Gln Phe Glu Arg 
    50                  55                  60                  


Leu Xaa Arg Glu Leu Glu Ala Glu Arg Gln Ile Val Ala Ser Gln Leu 
65                  70                  75                  80  


Glu Arg Cys Lys Leu Gly Ser Glu Xaa Gly Ser Met Ser Ser Met Ser 
                85                  90                  95      


Ser Ala Glu Glu Gln Phe Gln Trp Gln Ser Gln Asp Gly Gln Lys Asp 
            100                 105                 110         


Ile Glu Asp Glu Leu Xaa Xaa Gly Leu Glu Leu Val Asp Ser Cys Ile 
        115                 120                 125             


Arg Ser Leu Gln Glu Ser Gly Ile Leu Asp Pro Gln Asp Tyr Ser Xaa 
    130                 135                 140                 


Gly Glu Arg Pro Ser Leu Leu Ser Gln Ser Ala Leu Gln Leu Asn Ser 
145                 150                 155                 160 


Lys Pro Glu Gly Ser Phe Gln Tyr Pro Ala Ser Tyr His Ser Asn Gln 
                165                 170                 175     


Xaa Leu Ala Leu Gly Glu Xaa Xaa Pro Ser Gln Leu Pro Ala Arg Gly 
            180                 185                 190         


Xaa Gln Ala Arg Ala Xaa Gly Gln Ser Phe Ser Gln Leu Val Pro Glu 
        195                 200                 205             


Pro His Xaa Ala Ala Ser Met Gly Xaa Trp Ala Gln Ser Cys Gly Pro 
    210                 215                 220                 


Cys Ser Pro Gln Asn Xaa Xaa 
225                 230     


<210> 7277
<211> 912
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (693)..(693)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (738)..(738)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (745)..(745)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (886)..(886)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<400> 7277
Met Phe Ala Arg Lys Pro Pro Gly Ala Ala Pro Leu Gly Ala Met Pro 
1               5                   10                  15      


Val Pro Asp Gln Pro Ser Ser Ala Ser Glu Lys Xaa Ser Ser Leu Ser 
            20                  25                  30          


Pro Gly Leu Asn Xaa Ser Asn Gly Asp Gly Ser Glu Xaa Glu Xaa Xaa 
        35                  40                  45              


Ser Ala Ile Leu Ala Ser Val Lys Glu Gln Glu Leu Gln Phe Glu Arg 
    50                  55                  60                  


Leu Xaa Arg Glu Leu Glu Ala Glu Arg Gln Ile Val Ala Ser Gln Leu 
65                  70                  75                  80  


Glu Arg Cys Lys Leu Gly Ser Glu Xaa Gly Ser Met Ser Ser Met Ser 
                85                  90                  95      


Ser Ala Glu Glu Gln Phe Gln Trp Gln Ser Gln Asp Gly Gln Lys Asp 
            100                 105                 110         


Ile Glu Asp Glu Leu Xaa Xaa Gly Leu Glu Leu Val Asp Ser Cys Ile 
        115                 120                 125             


Arg Ser Leu Gln Glu Ser Gly Ile Leu Asp Pro Gln Asp Tyr Ser Xaa 
    130                 135                 140                 


Gly Glu Xaa Gly Ser Arg Ala Ser Tyr Ser Ser Gln His Gly His Leu 
145                 150                 155                 160 


Gly Pro Glu Leu Arg Ala Leu Gln Ser Pro Glu His His Ile Asp Pro 
                165                 170                 175     


Ile Tyr Glu Asp Arg Val Tyr Gln Lys Pro Pro Met Arg Ser Leu Ser 
            180                 185                 190         


Gln Ser Gln Gly Asp Pro Leu Pro Pro Ala His Xaa Gly Xaa Tyr Arg 
        195                 200                 205             


Xaa Ser Xaa Ala Pro Ser Ser Pro Gly Val Asp Ser Val Pro Leu Gln 
    210                 215                 220                 


Arg Xaa Gly Ser Gln His Gly Pro Gln Asn Ala Ala Ala Ala Xaa Phe 
225                 230                 235                 240 


Gln Arg Ala Ser Tyr Ala Ala Gly Pro Ala Ser Asn Tyr Ala Asp Pro 
                245                 250                 255     


Tyr Arg Gln Leu Gln Tyr Cys Pro Ser Val Glu Ser Pro Tyr Ser Lys 
            260                 265                 270         


Ser Gly Pro Ala Leu Pro Pro Glu Gly Xaa Leu Ala Arg Ser Pro Ser 
        275                 280                 285             


Ile Asp Ser Ile Gln Lys Asp Pro Arg Glu Phe Gly Trp Arg Asp Pro 
    290                 295                 300                 


Glu Leu Pro Glu Val Ile Gln Met Leu Gln His Gln Phe Pro Ser Val 
305                 310                 315                 320 


Gln Ser Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Phe Gly Asp Asn 
                325                 330                 335     


Lys Ile Lys Ala Glu Ile Arg Arg Gln Gly Gly Ile Gln Leu Leu Val 
            340                 345                 350         


Asp Leu Leu Asp His Arg Met Xaa Glu Val His Arg Ser Ala Cys Gly 
        355                 360                 365             


Ala Leu Arg Asn Leu Val Tyr Gly Lys Ala Asn Asp Asp Asn Lys Ile 
    370                 375                 380                 


Ala Leu Lys Asn Cys Gly Gly Ile Pro Ala Leu Val Arg Leu Leu Arg 
385                 390                 395                 400 


Lys Xaa Xaa Asp Leu Glu Ile Arg Glu Leu Val Xaa Gly Val Leu Trp 
                405                 410                 415     


Asn Leu Ser Ser Cys Asp Ala Leu Lys Met Pro Ile Ile Gln Asp Ala 
            420                 425                 430         


Leu Ala Val Leu Xaa Asn Ala Val Ile Ile Pro His Ser Gly Trp Glu 
        435                 440                 445             


Asn Ser Pro Leu Gln Asp Asp Arg Lys Ile Gln Leu His Ser Ser Gln 
    450                 455                 460                 


Val Leu Arg Asn Ala Xaa Gly Cys Leu Arg Asn Val Ser Ser Ala Gly 
465                 470                 475                 480 


Glu Glu Ala Arg Arg Arg Met Arg Glu Cys Asp Gly Leu Xaa Asp Ala 
                485                 490                 495     


Leu Leu Tyr Val Ile Gln Ser Ala Leu Gly Ser Ser Glu Ile Asp Ser 
            500                 505                 510         


Lys Xaa Val Glu Asn Cys Val Cys Ile Leu Arg Asn Leu Ser Tyr Arg 
        515                 520                 525             


Leu Ala Ala Glu Xaa Ser Gln Gly Gln His Met Gly Xaa Asp Glu Leu 
    530                 535                 540                 


Asp Gly Leu Leu Cys Gly Glu Ala Asn Gly Lys Asp Ala Glu Ser Ser 
545                 550                 555                 560 


Gly Cys Trp Gly Lys Lys Lys Lys Lys Lys Lys Ser Gln Asp Gln Trp 
                565                 570                 575     


Asp Gly Val Gly Pro Leu Pro Asp Cys Ala Glu Pro Pro Lys Gly Ile 
            580                 585                 590         


Gln Met Leu Trp His Pro Ser Ile Val Lys Pro Tyr Leu Xaa Leu Leu 
        595                 600                 605             


Ser Glu Cys Ser Asn Pro Asp Xaa Leu Glu Gly Ala Ala Gly Ala Leu 
    610                 615                 620                 


Gln Asn Leu Ala Ala Gly Ser Trp Lys Gly Trp Ala Glu Asp Val Ala 
625                 630                 635                 640 


Gly Met Ala Tyr Ala Leu Arg Ser Leu Pro Glu Gly Ala Pro Cys Leu 
                645                 650                 655     


Pro Gln Trp Ser Val Tyr Ile Arg Ala Ala Val Arg Lys Glu Lys Gly 
            660                 665                 670         


Leu Pro Ile Leu Val Glu Leu Leu Arg Ile Asp Asn Asp Arg Val Val 
        675                 680                 685             


Cys Ala Val Ala Xaa Ala Leu Arg Asn Met Ala Leu Asp Val Arg Asn 
    690                 695                 700                 


Lys Glu Leu Ile Gly Lys Tyr Ala Met Arg Asp Leu Val His Arg Leu 
705                 710                 715                 720 


Pro Gly Gly Asn Asn Ser Asn Asn Xaa Ala Ser Lys Ala Met Ser Asp 
                725                 730                 735     


Asp Xaa Val Xaa Ala Val Cys Cys Xaa Leu His Glu Val Ile Xaa Lys 
            740                 745                 750         


Asn Met Glu Asn Ala Lys Ala Leu Arg Asp Ala Gly Gly Ile Glu Lys 
        755                 760                 765             


Leu Val Gly Ile Ser Lys Ser Lys Gly Asp Lys His Ser Pro Lys Val 
    770                 775                 780                 


Val Lys Ala Ala Ser Gln Val Leu Asn Ser Met Trp Gln Tyr Arg Asp 
785                 790                 795                 800 


Leu Arg Ser Leu Tyr Lys Lys Asp Gly Trp Ser Gln Tyr His Phe Val 
                805                 810                 815     


Ala Ser Ser Ser Xaa Ile Glu Arg Asp Arg Gln Arg Pro Tyr Ser Ser 
            820                 825                 830         


Ser Arg Xaa Pro Ser Ile Ser Pro Val Arg Val Ser Pro Asn Asn Arg 
        835                 840                 845             


Ser Ala Ser Ala Pro Ala Ser Pro Arg Glu Met Ile Ser Leu Lys Glu 
    850                 855                 860                 


Arg Lys Xaa Asp Tyr Glu Cys Xaa Gly Ser Asn Ala Xaa Tyr His Gly 
865                 870                 875                 880 


Ala Lys Gly Glu His Xaa Ser Arg Lys Asp Ala Met Xaa Gly Ala His 
                885                 890                 895     


Ser Ala Ser Met Cys Arg Pro Tyr Lys Gly Xaa Pro Gln Arg Cys Ser 
            900                 905                 910         


<210> 7278
<211> 169
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 7278
Met Pro Val Pro Asp Gln Pro Ser Ser Ala Ser Glu Lys Xaa Ser Ser 
1               5                   10                  15      


Leu Ser Pro Gly Leu Asn Xaa Ser Asn Gly Asp Gly Ser Glu Xaa Glu 
            20                  25                  30          


Xaa Xaa Ser Ala Ile Leu Ala Ser Val Lys Glu Gln Glu Leu Gln Phe 
        35                  40                  45              


Glu Arg Leu Xaa Arg Glu Leu Glu Ala Glu Arg Gln Ile Val Ala Ser 
    50                  55                  60                  


Gln Leu Glu Arg Cys Lys Leu Gly Ser Glu Xaa Gly Ser Met Ser Ser 
65                  70                  75                  80  


Met Ser Ser Ala Glu Glu Gln Phe Gln Trp Gln Ser Gln Asp Gly Gln 
                85                  90                  95      


Lys Asp Ile Glu Asp Glu Leu Xaa Xaa Gly Leu Glu Leu Val Asp Ser 
            100                 105                 110         


Cys Ile Arg Ser Leu Gln Glu Ser Gly Ile Leu Asp Pro Gln Asp Tyr 
        115                 120                 125             


Ser Xaa Gly Glu Arg Pro Ser Leu Leu Ser Gln Ser Ala Leu Gln Leu 
    130                 135                 140                 


Asn Ser Lys Pro Glu Gly Ser Phe Gln Tyr Pro Ala Ser Tyr His Ser 
145                 150                 155                 160 


Asn Gln Xaa Leu Ala Leu Gly Glu Xaa 
                165                 


<210> 7279
<211> 209
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<400> 7279
Met Pro Val Pro Asp Gln Pro Ser Ser Ala Ser Glu Lys Xaa Ser Ser 
1               5                   10                  15      


Leu Ser Pro Gly Leu Asn Xaa Ser Asn Gly Asp Gly Ser Glu Xaa Glu 
            20                  25                  30          


Xaa Xaa Ser Ala Ile Leu Ala Ser Val Lys Glu Gln Glu Leu Gln Phe 
        35                  40                  45              


Glu Arg Leu Xaa Arg Glu Leu Glu Ala Glu Arg Gln Ile Val Ala Ser 
    50                  55                  60                  


Gln Leu Glu Arg Cys Lys Leu Gly Ser Glu Xaa Gly Ser Met Ser Ser 
65                  70                  75                  80  


Met Ser Ser Ala Glu Glu Gln Phe Gln Trp Gln Ser Gln Asp Gly Gln 
                85                  90                  95      


Lys Asp Ile Glu Asp Glu Leu Xaa Xaa Gly Leu Glu Leu Val Asp Ser 
            100                 105                 110         


Cys Ile Arg Ser Leu Gln Glu Ser Gly Ile Leu Asp Pro Gln Asp Tyr 
        115                 120                 125             


Ser Xaa Gly Glu Xaa Gly Ser Arg Ala Ser Tyr Ser Ser Gln His Gly 
    130                 135                 140                 


His Leu Gly Pro Glu Leu Arg Ala Leu Gln Ser Pro Glu His His Ile 
145                 150                 155                 160 


Asp Pro Ile Tyr Glu Asp Arg Val Tyr Gln Lys Pro Pro Met Arg Ser 
                165                 170                 175     


Leu Ser Gln Ser Gln Gly Asp Pro Leu Pro Pro Ala His Xaa Gly Xaa 
            180                 185                 190         


Tyr Arg Xaa Ser Xaa Ala Pro Ser Ser Pro Gly Val Asp Ser Val Pro 
        195                 200                 205             


Leu 
    


<210> 7280
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<400> 7280
Met Ser Ser Met Ser Ser Ala Glu Glu Gln Phe Gln Trp Gln Ser Gln 
1               5                   10                  15      


Asp Gly Gln Lys Asp Ile Glu Asp Glu Leu Xaa Xaa Gly Leu Glu Leu 
            20                  25                  30          


Val Asp Ser Cys Ile Arg Ser Leu Gln Glu Ser Gly Ile Leu Asp Pro 
        35                  40                  45              


Gln Asp Tyr Ser Xaa Gly Glu Arg Pro Ser Leu Leu Ser Gln Ser Ala 
    50                  55                  60                  


Leu Gln Leu Asn Ser Lys Pro Glu Gly Ser Phe Gln Tyr Pro Ala Ser 
65                  70                  75                  80  


Tyr His Ser Asn Gln Xaa Leu Ala Leu Gly Glu Xaa Xaa Pro Ser Gln 
                85                  90                  95      


Leu Pro Ala Arg Gly Xaa Gln Ala Arg Ala Xaa Gly Gln Ser Phe Ser 
            100                 105                 110         


Gln Gly Xaa Xaa Ser Arg Ala Gly His Leu Ala Gly Pro Glu Pro Ala 
        115                 120                 125             


Pro Pro Pro Pro Pro Pro Pro Arg Glu Pro Phe Ala Pro Ser Leu Gly 
    130                 135                 140                 


Ser Ala Phe His Leu Pro Asp Ala Pro Pro Ala Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Leu Tyr Tyr Ser Ser Ser Xaa Leu Pro Ala Pro Pro Arg Gly Gly Ser 
                165                 170                 175     


Pro Leu Ala Ala Pro 
            180     


<210> 7281
<211> 1134
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (823)..(823)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (859)..(859)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (881)..(881)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (997)..(997)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1007)..(1007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1016)..(1016)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1103)..(1103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1123)..(1123)
<223> Selenocysteine

<400> 7281
Met Ser Ser Met Ser Ser Ala Glu Glu Gln Phe Gln Trp Gln Ser Gln 
1               5                   10                  15      


Asp Gly Gln Lys Asp Ile Glu Asp Glu Leu Xaa Xaa Gly Leu Glu Leu 
            20                  25                  30          


Val Asp Ser Cys Ile Arg Ser Leu Gln Glu Ser Gly Ile Leu Asp Pro 
        35                  40                  45              


Gln Asp Tyr Ser Xaa Gly Glu Arg Pro Ser Leu Leu Ser Gln Ser Ala 
    50                  55                  60                  


Leu Gln Leu Asn Ser Lys Pro Glu Gly Ser Phe Gln Tyr Pro Ala Ser 
65                  70                  75                  80  


Tyr His Ser Asn Gln Xaa Leu Ala Leu Gly Glu Xaa Xaa Pro Ser Gln 
                85                  90                  95      


Leu Pro Ala Arg Gly Xaa Gln Ala Arg Ala Xaa Gly Gln Ser Phe Ser 
            100                 105                 110         


Gln Gly Xaa Xaa Ser Arg Ala Gly His Leu Ala Gly Pro Glu Pro Ala 
        115                 120                 125             


Pro Pro Pro Pro Pro Pro Pro Arg Glu Pro Phe Ala Pro Ser Leu Gly 
    130                 135                 140                 


Ser Ala Phe His Leu Pro Asp Ala Pro Pro Ala Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Leu Tyr Tyr Ser Ser Ser Xaa Leu Pro Ala Pro Pro Arg Gly Gly Ser 
                165                 170                 175     


Pro Leu Ala Ala Pro Gln Gly Gly Ser Pro Xaa Lys Leu Gln Arg Gly 
            180                 185                 190         


Gly Ser Ala Pro Glu Gly Ala Xaa Tyr Ala Ala Pro Arg Gly Ser Ser 
        195                 200                 205             


Pro Lys Gln Ser Pro Ser Arg Leu Ala Lys Ser Tyr Ser Xaa Ser Ser 
    210                 215                 220                 


Pro Ile Asn Ile Val Val Ser Ser Ala Gly Leu Ser Pro Ile Arg Val 
225                 230                 235                 240 


Xaa Ser Pro Pro Xaa Val Gln Ser Xaa Ile Ser Ser Ser Pro Ile His 
                245                 250                 255     


Gln Leu Ser Ser Xaa Ile Gly Xaa Tyr Ala Xaa Leu Ser Pro Xaa Lys 
            260                 265                 270         


Arg Leu Val His Ala Ser Glu Gln Tyr Ser Lys His Ser Gln Glu Leu 
        275                 280                 285             


Tyr Ala Xaa Ala Xaa Leu Gln Arg Pro Gly Ser Leu Ala Ala Gly Ser 
    290                 295                 300                 


Arg Ala Ser Tyr Ser Ser Gln His Gly His Leu Gly Pro Glu Leu Arg 
305                 310                 315                 320 


Ala Leu Gln Ser Pro Glu His His Ile Asp Pro Ile Tyr Glu Asp Arg 
                325                 330                 335     


Val Tyr Gln Lys Pro Pro Met Arg Ser Leu Ser Gln Ser Gln Gly Asp 
            340                 345                 350         


Pro Leu Pro Pro Ala His Xaa Gly Xaa Tyr Arg Xaa Ser Xaa Ala Pro 
        355                 360                 365             


Ser Ser Pro Gly Val Asp Ser Val Pro Leu Gln Arg Xaa Gly Ser Gln 
    370                 375                 380                 


His Gly Pro Gln Asn Ala Ala Ala Ala Xaa Phe Gln Arg Ala Ser Tyr 
385                 390                 395                 400 


Ala Ala Gly Pro Ala Ser Asn Tyr Ala Asp Pro Tyr Arg Gln Leu Gln 
                405                 410                 415     


Tyr Cys Pro Ser Val Glu Ser Pro Tyr Ser Lys Ser Gly Pro Ala Leu 
            420                 425                 430         


Pro Pro Glu Gly Xaa Leu Ala Arg Ser Pro Ser Ile Asp Ser Ile Gln 
        435                 440                 445             


Lys Asp Pro Arg Glu Phe Gly Trp Arg Asp Pro Glu Leu Pro Glu Val 
    450                 455                 460                 


Ile Gln Met Leu Gln His Gln Phe Pro Ser Val Gln Ser Asn Ala Ala 
465                 470                 475                 480 


Ala Tyr Leu Gln His Leu Cys Phe Gly Asp Asn Lys Ile Lys Ala Glu 
                485                 490                 495     


Ile Arg Arg Gln Gly Gly Ile Gln Leu Leu Val Asp Leu Leu Asp His 
            500                 505                 510         


Arg Met Xaa Glu Val His Arg Ser Ala Cys Gly Ala Leu Arg Asn Leu 
        515                 520                 525             


Val Tyr Gly Lys Ala Asn Asp Asp Asn Lys Ile Ala Leu Lys Asn Cys 
    530                 535                 540                 


Gly Gly Ile Pro Ala Leu Val Arg Leu Leu Arg Lys Xaa Xaa Asp Leu 
545                 550                 555                 560 


Glu Ile Arg Glu Leu Val Xaa Gly Val Leu Trp Asn Leu Ser Ser Cys 
                565                 570                 575     


Asp Ala Leu Lys Met Pro Ile Ile Gln Asp Ala Leu Ala Val Leu Xaa 
            580                 585                 590         


Asn Ala Val Ile Ile Pro His Ser Gly Trp Glu Asn Ser Pro Leu Gln 
        595                 600                 605             


Asp Asp Arg Lys Ile Gln Leu His Ser Ser Gln Val Leu Arg Asn Ala 
    610                 615                 620                 


Xaa Gly Cys Leu Arg Asn Val Ser Ser Ala Gly Glu Glu Ala Arg Arg 
625                 630                 635                 640 


Arg Met Arg Glu Cys Asp Gly Leu Xaa Asp Ala Leu Leu Tyr Val Ile 
                645                 650                 655     


Gln Ser Ala Leu Gly Ser Ser Glu Ile Asp Ser Lys Xaa Val Glu Asn 
            660                 665                 670         


Cys Val Cys Ile Leu Arg Asn Leu Ser Tyr Arg Leu Ala Ala Glu Xaa 
        675                 680                 685             


Ser Gln Gly Gln His Met Gly Xaa Asp Glu Leu Asp Gly Leu Leu Cys 
    690                 695                 700                 


Gly Glu Ala Asn Gly Lys Asp Ala Glu Ser Ser Gly Cys Trp Gly Lys 
705                 710                 715                 720 


Lys Lys Lys Lys Lys Lys Ser Gln Asp Gln Trp Asp Gly Val Gly Pro 
                725                 730                 735     


Leu Pro Asp Cys Ala Glu Pro Pro Lys Gly Ile Gln Met Leu Trp His 
            740                 745                 750         


Pro Ser Ile Val Lys Pro Tyr Leu Xaa Leu Leu Ser Glu Cys Ser Asn 
        755                 760                 765             


Pro Asp Xaa Leu Glu Gly Ala Ala Gly Ala Leu Gln Asn Leu Ala Ala 
    770                 775                 780                 


Gly Ser Trp Lys Trp Ser Val Tyr Ile Arg Ala Ala Val Arg Lys Glu 
785                 790                 795                 800 


Lys Gly Leu Pro Ile Leu Val Glu Leu Leu Arg Ile Asp Asn Asp Arg 
                805                 810                 815     


Val Val Cys Ala Val Ala Xaa Ala Leu Arg Asn Met Ala Leu Asp Val 
            820                 825                 830         


Arg Asn Lys Glu Leu Ile Gly Lys Tyr Ala Met Arg Asp Leu Val His 
        835                 840                 845             


Arg Leu Pro Gly Gly Asn Asn Ser Asn Asn Xaa Ala Ser Lys Ala Met 
    850                 855                 860                 


Ser Asp Asp Xaa Val Xaa Ala Val Cys Cys Xaa Leu His Glu Val Ile 
865                 870                 875                 880 


Xaa Lys Asn Met Glu Asn Ala Lys Ala Leu Arg Asp Ala Gly Gly Ile 
                885                 890                 895     


Glu Lys Leu Val Gly Ile Ser Lys Ser Lys Gly Asp Lys His Ser Pro 
            900                 905                 910         


Lys Val Val Lys Ala Ala Ser Gln Val Leu Asn Ser Met Trp Gln Tyr 
        915                 920                 925             


Arg Asp Leu Arg Ser Leu Tyr Lys Lys Asp Gly Trp Ser Gln Tyr His 
    930                 935                 940                 


Phe Val Ala Ser Ser Ser Xaa Ile Glu Arg Asp Arg Gln Arg Pro Tyr 
945                 950                 955                 960 


Ser Ser Ser Arg Xaa Pro Ser Ile Ser Pro Val Arg Val Ser Pro Asn 
                965                 970                 975     


Asn Arg Ser Ala Ser Ala Pro Ala Ser Pro Arg Glu Met Ile Ser Leu 
            980                 985                 990         


Lys Glu Arg Lys Xaa Asp Tyr Glu  Cys Xaa Gly Ser Asn  Ala Xaa Tyr 
        995                 1000                 1005             


His Gly  Ala Lys Gly Glu His  Xaa Ser Arg Lys Asp  Ala Met Xaa 
    1010                 1015                 1020             


Ala Gln  Asn Xaa Gly Ile Ser  Xaa Leu Tyr Arg Asn  Ser Tyr Gly 
    1025                 1030                 1035             


Ala Pro  Ala Glu Asp Ile Lys  His Asn Gln Val Ser  Ala Gln Pro 
    1040                 1045                 1050             


Val Pro  Gln Glu Pro Ser Arg  Lys Asp Tyr Glu Xaa  Tyr Gln Pro 
    1055                 1060                 1065             


Phe Gln  Asn Ser Xaa Arg Asn  Tyr Asp Glu Ser Phe  Phe Glu Asp 
    1070                 1075                 1080             


Gln Val  His His Arg Pro Pro  Ala Ser Glu Tyr Xaa  Met His Leu 
    1085                 1090                 1095             


Gly Leu  Lys Ser Xaa Gly Asn  Tyr Val Asp Phe Tyr  Ser Ala Ala 
    1100                 1105                 1110             


Arg Pro  Tyr Ser Glu Leu Asn  Tyr Glu Xaa Ser His  Tyr Pro Ala 
    1115                 1120                 1125             


Ser Pro  Asp Ser Trp Val 
    1130                 


<210> 7282
<211> 888
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (761)..(761)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (827)..(827)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<400> 7282
Met Ser Ser Met Ser Ser Ala Glu Glu Gln Phe Gln Trp Gln Ser Gln 
1               5                   10                  15      


Asp Gly Gln Lys Asp Ile Glu Asp Glu Leu Xaa Xaa Gly Leu Glu Leu 
            20                  25                  30          


Val Asp Ser Cys Ile Arg Ser Leu Gln Glu Ser Gly Ile Leu Asp Pro 
        35                  40                  45              


Gln Asp Tyr Ser Xaa Gly Glu Xaa Gly Ser Arg Ala Ser Tyr Ser Ser 
    50                  55                  60                  


Gln His Gly His Leu Gly Pro Glu Leu Arg Ala Leu Gln Ser Pro Glu 
65                  70                  75                  80  


His His Ile Asp Pro Ile Tyr Glu Asp Arg Val Tyr Gln Lys Pro Pro 
                85                  90                  95      


Met Arg Ser Leu Ser Gln Ser Gln Gly Asp Pro Leu Pro Pro Ala His 
            100                 105                 110         


Xaa Gly Xaa Tyr Arg Xaa Ser Xaa Ala Pro Ser Ser Pro Gly Val Asp 
        115                 120                 125             


Ser Val Pro Leu Gln Arg Xaa Gly Ser Gln His Gly Pro Gln Asn Ala 
    130                 135                 140                 


Ala Ala Ala Xaa Phe Gln Arg Ala Ser Tyr Ala Ala Gly Pro Ala Ser 
145                 150                 155                 160 


Asn Tyr Ala Asp Pro Tyr Arg Gln Leu Gln Tyr Cys Pro Ser Val Glu 
                165                 170                 175     


Ser Pro Tyr Ser Lys Ser Gly Pro Ala Leu Pro Pro Glu Gly Xaa Leu 
            180                 185                 190         


Ala Arg Ser Pro Ser Ile Asp Ser Ile Gln Lys Asp Pro Arg Glu Phe 
        195                 200                 205             


Gly Trp Arg Asp Pro Glu Leu Pro Glu Val Ile Gln Met Leu Gln His 
    210                 215                 220                 


Gln Phe Pro Ser Val Gln Ser Asn Ala Ala Ala Tyr Leu Gln His Leu 
225                 230                 235                 240 


Cys Phe Gly Asp Asn Lys Ile Lys Ala Glu Ile Arg Arg Gln Gly Gly 
                245                 250                 255     


Ile Gln Leu Leu Val Asp Leu Leu Asp His Arg Met Xaa Glu Val His 
            260                 265                 270         


Arg Ser Ala Cys Gly Ala Leu Arg Asn Leu Val Tyr Gly Lys Ala Asn 
        275                 280                 285             


Asp Asp Asn Lys Ile Ala Leu Lys Asn Cys Gly Gly Ile Pro Ala Leu 
    290                 295                 300                 


Val Arg Leu Leu Arg Lys Xaa Xaa Asp Leu Glu Ile Arg Glu Leu Val 
305                 310                 315                 320 


Xaa Gly Val Leu Trp Asn Leu Ser Ser Cys Asp Ala Leu Lys Met Pro 
                325                 330                 335     


Ile Ile Gln Asp Ala Leu Ala Val Leu Xaa Asn Ala Val Ile Ile Pro 
            340                 345                 350         


His Ser Gly Trp Glu Asn Ser Pro Leu Gln Asp Asp Arg Lys Ile Gln 
        355                 360                 365             


Leu His Ser Ser Gln Val Leu Arg Asn Ala Xaa Gly Cys Leu Arg Asn 
    370                 375                 380                 


Val Ser Ser Ala Gly Glu Glu Ala Arg Arg Arg Met Arg Glu Cys Asp 
385                 390                 395                 400 


Gly Leu Xaa Asp Ala Leu Leu Tyr Val Ile Gln Ser Ala Leu Gly Ser 
                405                 410                 415     


Ser Glu Ile Asp Ser Lys Xaa Val Glu Asn Cys Val Cys Ile Leu Arg 
            420                 425                 430         


Asn Leu Ser Tyr Arg Leu Ala Ala Glu Xaa Ser Gln Gly Gln His Met 
        435                 440                 445             


Gly Xaa Asp Glu Leu Asp Gly Leu Leu Cys Gly Glu Ala Asn Gly Lys 
    450                 455                 460                 


Asp Ala Glu Ser Ser Gly Cys Trp Gly Lys Lys Lys Lys Lys Lys Lys 
465                 470                 475                 480 


Ser Gln Asp Gln Trp Asp Gly Val Gly Pro Leu Pro Asp Cys Ala Glu 
                485                 490                 495     


Pro Pro Lys Gly Ile Gln Met Leu Trp His Pro Ser Ile Val Lys Pro 
            500                 505                 510         


Tyr Leu Xaa Leu Leu Ser Glu Cys Ser Asn Pro Asp Xaa Leu Glu Gly 
        515                 520                 525             


Ala Ala Gly Ala Leu Gln Asn Leu Ala Ala Gly Ser Trp Lys Trp Ser 
    530                 535                 540                 


Val Tyr Ile Arg Ala Ala Val Arg Lys Glu Lys Gly Leu Pro Ile Leu 
545                 550                 555                 560 


Val Glu Leu Leu Arg Ile Asp Asn Asp Arg Val Val Cys Ala Val Ala 
                565                 570                 575     


Xaa Ala Leu Arg Asn Met Ala Leu Asp Val Arg Asn Lys Glu Leu Ile 
            580                 585                 590         


Gly Lys Tyr Ala Met Arg Asp Leu Val His Arg Leu Pro Gly Gly Asn 
        595                 600                 605             


Asn Ser Asn Asn Xaa Ala Ser Lys Ala Met Ser Asp Asp Xaa Val Xaa 
    610                 615                 620                 


Ala Val Cys Cys Xaa Leu His Glu Val Ile Xaa Lys Asn Met Glu Asn 
625                 630                 635                 640 


Ala Lys Ala Leu Arg Asp Ala Gly Gly Ile Glu Lys Leu Val Gly Ile 
                645                 650                 655     


Ser Lys Ser Lys Gly Asp Lys His Ser Pro Lys Val Val Lys Ala Ala 
            660                 665                 670         


Ser Gln Val Leu Asn Ser Met Trp Gln Tyr Arg Asp Leu Arg Ser Leu 
        675                 680                 685             


Tyr Lys Lys Asp Gly Trp Ser Gln Tyr His Phe Val Ala Ser Ser Ser 
    690                 695                 700                 


Xaa Ile Glu Arg Asp Arg Gln Arg Pro Tyr Ser Ser Ser Arg Xaa Pro 
705                 710                 715                 720 


Ser Ile Ser Pro Val Arg Val Ser Pro Asn Asn Arg Ser Ala Ser Ala 
                725                 730                 735     


Pro Ala Ser Pro Arg Glu Met Ile Ser Leu Lys Glu Arg Lys Xaa Asp 
            740                 745                 750         


Tyr Glu Cys Xaa Gly Ser Asn Ala Xaa Tyr His Gly Ala Lys Gly Glu 
        755                 760                 765             


His Xaa Ser Arg Lys Asp Ala Met Xaa Ala Gln Asn Xaa Gly Ile Ser 
    770                 775                 780                 


Xaa Leu Tyr Arg Asn Ser Tyr Gly Ala Pro Ala Glu Asp Ile Lys His 
785                 790                 795                 800 


Asn Gln Val Ser Ala Gln Pro Val Pro Gln Glu Pro Ser Arg Lys Asp 
                805                 810                 815     


Tyr Glu Xaa Tyr Gln Pro Phe Gln Asn Ser Xaa Arg Asn Tyr Asp Glu 
            820                 825                 830         


Ser Phe Phe Glu Asp Gln Val His His Arg Pro Pro Ala Ser Glu Tyr 
        835                 840                 845             


Xaa Met His Leu Gly Leu Lys Ser Xaa Gly Asn Tyr Val Asp Phe Tyr 
    850                 855                 860                 


Ser Ala Ala Arg Pro Tyr Ser Glu Leu Asn Tyr Glu Xaa Ser His Tyr 
865                 870                 875                 880 


Pro Ala Ser Pro Asp Ser Trp Val 
                885             


<210> 7283
<211> 320
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<400> 7283
Met Xaa Val Trp Cys Ala Val Ala Xaa Ala Leu Arg Asn Met Ala Leu 
1               5                   10                  15      


Asp Val Arg Asn Lys Glu Leu Ile Gly Lys Tyr Ala Met Arg Asp Leu 
            20                  25                  30          


Val His Arg Leu Pro Gly Gly Asn Asn Ser Asn Asn Xaa Ala Ser Lys 
        35                  40                  45              


Ala Met Ser Asp Asp Xaa Val Xaa Ala Val Cys Cys Xaa Leu His Glu 
    50                  55                  60                  


Val Ile Xaa Lys Asn Met Glu Asn Ala Lys Ala Leu Arg Asp Ala Gly 
65                  70                  75                  80  


Gly Ile Glu Lys Leu Val Gly Ile Ser Lys Ser Lys Gly Asp Lys His 
                85                  90                  95      


Ser Pro Lys Val Val Lys Ala Ala Ser Gln Val Leu Asn Ser Met Trp 
            100                 105                 110         


Gln Tyr Arg Asp Leu Arg Ser Leu Tyr Lys Lys Asp Gly Trp Ser Gln 
        115                 120                 125             


Tyr His Phe Val Ala Ser Ser Ser Xaa Ile Glu Arg Asp Arg Gln Arg 
    130                 135                 140                 


Pro Tyr Ser Ser Ser Arg Xaa Pro Ser Ile Ser Pro Val Arg Val Ser 
145                 150                 155                 160 


Pro Asn Asn Arg Ser Ala Ser Ala Pro Ala Ser Pro Arg Glu Met Ile 
                165                 170                 175     


Ser Leu Lys Glu Arg Lys Xaa Asp Tyr Glu Cys Xaa Gly Ser Asn Ala 
            180                 185                 190         


Xaa Tyr His Gly Ala Lys Gly Glu His Xaa Ser Arg Lys Asp Ala Met 
        195                 200                 205             


Xaa Ala Gln Asn Xaa Gly Ile Ser Xaa Leu Tyr Arg Asn Ser Tyr Gly 
    210                 215                 220                 


Ala Pro Ala Glu Asp Ile Lys His Asn Gln Val Ser Ala Gln Pro Val 
225                 230                 235                 240 


Pro Gln Glu Pro Ser Arg Lys Asp Tyr Glu Xaa Tyr Gln Pro Phe Gln 
                245                 250                 255     


Asn Ser Xaa Arg Asn Tyr Asp Glu Ser Phe Phe Glu Asp Gln Val His 
            260                 265                 270         


His Arg Pro Pro Ala Ser Glu Tyr Xaa Met His Leu Gly Leu Lys Ser 
        275                 280                 285             


Xaa Gly Asn Tyr Val Asp Phe Tyr Ser Ala Ala Arg Pro Tyr Ser Glu 
    290                 295                 300                 


Leu Asn Tyr Glu Xaa Ser His Tyr Pro Ala Ser Pro Asp Ser Trp Val 
305                 310                 315                 320 


<210> 7284
<211> 300
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<400> 7284
Asp Glu Val Ile Glu Leu Asp Phe Asp Gln Leu Pro Glu Gly Asp Glu 
1               5                   10                  15      


Val Ile Ser Ile Leu Lys Gln Glu His Xaa Gln Leu His Ile Trp Ile 
            20                  25                  30          


Ala Leu Ala Leu Glu Tyr Tyr Lys Gln Gly Lys Xaa Glu Glu Phe Val 
        35                  40                  45              


Lys Leu Leu Glu Ala Ala Arg Ile Asp Gly Asn Leu Asp Tyr Arg Asp 
    50                  55                  60                  


His Glu Lys Asp Gln Met Xaa Cys Leu Asp Xaa Leu Ala Ala Tyr Tyr 
65                  70                  75                  80  


Val Gln Gln Ala Arg Lys Glu Lys Asn Lys Asp Asn Lys Lys Asp Leu 
                85                  90                  95      


Ile Xaa Gln Ala Xaa Leu Leu Tyr Xaa Met Ala Asp Lys Ile Ile Met 
            100                 105                 110         


Tyr Asp Gln Asn His Leu Leu Gly Arg Ala Cys Phe Cys Leu Leu Glu 
        115                 120                 125             


Gly Asp Lys Met Asp Gln Ala Asp Ala Gln Phe His Phe Val Leu Asn 
    130                 135                 140                 


Gln Ser Pro Asn Asn Ile Pro Ala Leu Leu Gly Lys Ala Cys Ile Ser 
145                 150                 155                 160 


Phe Asn Lys Lys Asp Tyr Arg Gly Ala Leu Ala Tyr Tyr Lys Lys Ala 
                165                 170                 175     


Leu Arg Xaa Asn Pro Gly Cys Pro Ala Glu Val Arg Leu Gly Met Gly 
            180                 185                 190         


His Cys Phe Val Lys Leu Asn Lys Leu Glu Lys Ala Arg Leu Ala Phe 
        195                 200                 205             


Ser Arg Ala Leu Glu Leu Asn Ser Lys Cys Val Gly Ala Leu Val Gly 
    210                 215                 220                 


Leu Ala Val Leu Glu Leu Asn Asn Lys Glu Asp Tyr Ser Lys Val Gln 
225                 230                 235                 240 


His Leu Ala Leu His Ala Phe His Asn Xaa Glu Val Glu Ala Met Gln 
                245                 250                 255     


Ala Glu Ser Cys Tyr Gln Leu Ala Arg Ser Phe His Val Gln Glu Asp 
            260                 265                 270         


Tyr Asp Gln Ala Phe Gln Tyr Tyr Tyr Gln Ala Xaa Gln Phe Ala Ser 
        275                 280                 285             


Ser Ser Phe Val Leu Pro Phe Phe Gly Leu Gly Gln 
    290                 295                 300 


<210> 7285
<211> 1173
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (601)..(601)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (614)..(614)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (892)..(892)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (895)..(895)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (925)..(925)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<400> 7285
Met Ser Arg Gly Ser Ile Glu Ile Pro Leu Arg Asp Xaa Asp Glu Val 
1               5                   10                  15      


Ile Glu Leu Asp Phe Asp Gln Leu Pro Glu Gly Asp Glu Val Ile Ser 
            20                  25                  30          


Ile Leu Lys Gln Glu His Xaa Gln Leu His Ile Trp Ile Ala Leu Ala 
        35                  40                  45              


Leu Glu Tyr Tyr Lys Gln Gly Lys Xaa Glu Glu Phe Val Lys Leu Leu 
    50                  55                  60                  


Glu Ala Ala Arg Ile Asp Gly Asn Leu Asp Tyr Arg Asp His Glu Lys 
65                  70                  75                  80  


Asp Gln Met Xaa Cys Leu Asp Xaa Leu Ala Ala Tyr Tyr Val Gln Gln 
                85                  90                  95      


Ala Arg Lys Glu Lys Asn Lys Asp Asn Lys Lys Asp Leu Ile Xaa Gln 
            100                 105                 110         


Ala Xaa Leu Leu Tyr Xaa Met Ala Asp Lys Ile Ile Met Tyr Asp Gln 
        115                 120                 125             


Asn His Leu Leu Gly Arg Ala Cys Phe Cys Leu Leu Glu Gly Asp Lys 
    130                 135                 140                 


Met Asp Gln Ala Asp Ala Gln Phe His Phe Val Leu Asn Gln Ser Pro 
145                 150                 155                 160 


Asn Asn Ile Pro Ala Leu Leu Gly Lys Ala Cys Ile Ser Phe Asn Lys 
                165                 170                 175     


Lys Asp Tyr Arg Gly Ala Leu Ala Tyr Tyr Lys Lys Ala Leu Arg Xaa 
            180                 185                 190         


Asn Pro Gly Cys Pro Ala Glu Val Arg Leu Gly Met Gly His Cys Phe 
        195                 200                 205             


Val Lys Leu Asn Lys Leu Glu Lys Ala Arg Leu Ala Phe Ser Arg Ala 
    210                 215                 220                 


Leu Glu Leu Asn Ser Lys Cys Val Gly Ala Leu Val Gly Leu Ala Val 
225                 230                 235                 240 


Leu Glu Leu Asn Asn Lys Glu Ala Asp Ser Ile Lys Asn Gly Val Gln 
                245                 250                 255     


Leu Leu Ser Arg Ala Tyr Xaa Ile Asp Pro Ser Asn Pro Met Val Leu 
            260                 265                 270         


Asn His Leu Ala Asn His Phe Phe Phe Lys Lys Asp Tyr Ser Lys Val 
        275                 280                 285             


Gln His Leu Ala Leu His Ala Phe His Asn Xaa Glu Val Glu Ala Met 
    290                 295                 300                 


Gln Ala Glu Ser Cys Tyr Gln Leu Ala Arg Ser Phe His Val Gln Glu 
305                 310                 315                 320 


Asp Tyr Asp Gln Ala Phe Gln Tyr Tyr Tyr Gln Ala Xaa Gln Phe Ala 
                325                 330                 335     


Ser Ser Ser Phe Val Leu Pro Phe Phe Gly Leu Gly Gln Met Tyr Ile 
            340                 345                 350         


Tyr Arg Gly Asp Lys Glu Asn Ala Ser Gln Cys Phe Glu Lys Val Leu 
        355                 360                 365             


Lys Ala Tyr Pro Asn Asn Tyr Glu Xaa Met Lys Ile Leu Gly Ser Leu 
    370                 375                 380                 


Tyr Ala Ala Ser Glu Asp Gln Glu Lys Arg Asp Ile Ala Lys Gly His 
385                 390                 395                 400 


Leu Lys Lys Val Xaa Glu Gln Tyr Pro Asp Asp Val Glu Ala Trp Ile 
                405                 410                 415     


Glu Leu Ala Gln Ile Leu Glu Gln Xaa Asp Ile Gln Gly Ala Leu Ser 
            420                 425                 430         


Ala Tyr Gly Xaa Ala Xaa Arg Ile Leu Gln Glu Lys Val Gln Ala Asp 
        435                 440                 445             


Val Pro Pro Glu Ile Leu Asn Asn Val Gly Ala Leu His Phe Arg Leu 
    450                 455                 460                 


Gly Asn Leu Gly Glu Ala Lys Lys Tyr Phe Leu Ala Ser Leu Asp Arg 
465                 470                 475                 480 


Ala Lys Ala Glu Ala Glu His Asp Glu His Tyr Tyr Asn Ala Ile Ser 
                485                 490                 495     


Val Xaa Xaa Ser Tyr Asn Leu Ala Arg Leu Tyr Glu Ala Met Cys Glu 
            500                 505                 510         


Phe His Glu Ala Glu Lys Leu Tyr Lys Asn Ile Leu Arg Glu His Pro 
        515                 520                 525             


Asn Tyr Val Asp Cys Tyr Leu Arg Leu Gly Ala Met Ala Arg Asp Lys 
    530                 535                 540                 


Gly Asn Phe Tyr Glu Ala Ser Asp Trp Phe Lys Glu Ala Leu Gln Ile 
545                 550                 555                 560 


Asn Gln Asp His Pro Asp Ala Trp Ser Leu Ile Gly Asn Leu His Leu 
                565                 570                 575     


Ala Lys Gln Glu Trp Gly Pro Gly Gln Lys Lys Phe Glu Arg Ile Leu 
            580                 585                 590         


Lys Gln Pro Ser Xaa Gln Ser Asp Xaa Tyr Ser Met Leu Ala Leu Gly 
        595                 600                 605             


Asn Val Trp Leu Gln Xaa Leu His Gln Pro Xaa Arg Asp Arg Glu Lys 
    610                 615                 620                 


Glu Lys Arg His Gln Asp Arg Ala Leu Ala Ile Tyr Lys Gln Val Leu 
625                 630                 635                 640 


Arg Asn Asp Ala Lys Asn Leu Tyr Ala Ala Asn Gly Ile Gly Ala Val 
                645                 650                 655     


Leu Ala His Lys Gly Tyr Phe Arg Glu Ala Arg Asp Val Phe Ala Gln 
            660                 665                 670         


Val Arg Glu Ala Xaa Ala Asp Ile Ser Asp Val Trp Leu Asn Leu Ala 
        675                 680                 685             


His Ile Tyr Val Glu Gln Lys Gln Tyr Ile Ser Ala Val Gln Met Tyr 
    690                 695                 700                 


Glu Asn Cys Leu Arg Lys Phe Tyr Lys His Gln Asn Xaa Glu Val Val 
705                 710                 715                 720 


Leu Tyr Leu Ala Arg Ala Leu Phe Lys Cys Gly Lys Leu Gln Glu Cys 
                725                 730                 735     


Lys Gln Xaa Leu Leu Lys Ala Arg His Val Ala Pro Ser Asp Xaa Val 
            740                 745                 750         


Leu Met Phe Asn Val Ala Leu Val Leu Gln Arg Leu Ala Xaa Ser Val 
        755                 760                 765             


Leu Lys Asp Glu Lys Ser Asn Leu Lys Glu Val Leu Asn Ala Val Lys 
    770                 775                 780                 


Glu Leu Glu Leu Ala His Arg Tyr Phe Ser Tyr Leu Ser Lys Val Gly 
785                 790                 795                 800 


Asp Lys Met Arg Phe Asp Leu Ala Leu Ala Ala Xaa Glu Ala Arg Gln 
                805                 810                 815     


Cys Ser Asp Leu Leu Ser Gln Ala Gln Tyr His Val Ala Arg Ala Arg 
            820                 825                 830         


Lys Gln Asp Glu Glu Glu Arg Glu Leu Arg Ala Lys Gln Glu Gln Glu 
        835                 840                 845             


Lys Glu Leu Leu Arg Gln Lys Leu Leu Lys Glu Gln Glu Glu Lys Arg 
    850                 855                 860                 


Leu Arg Glu Lys Glu Glu Gln Lys Lys Leu Leu Glu Gln Arg Ala Gln 
865                 870                 875                 880 


Tyr Val Glu Lys Xaa Lys Asn Ile Leu Met Phe Xaa Gly Glu Xaa Glu 
                885                 890                 895     


Ala Xaa Lys Glu Lys Lys Arg Gly Gly Gly Gly Gly Arg Arg Ser Lys 
            900                 905                 910         


Lys Gly Gly Glu Phe Asp Glu Phe Val Asn Asp Asp Xaa Asp Asp Asp 
        915                 920                 925             


Leu Pro Ile Ser Lys Lys Lys Lys Arg Arg Lys Gly Ser Gly Ser Glu 
    930                 935                 940                 


Gln Glu Gly Glu Asp Glu Glu Gly Gly Glu Arg Lys Lys Lys Lys Arg 
945                 950                 955                 960 


Arg Arg His Pro Lys Gly Glu Glu Gly Ser Asp Asp Asp Glu Xaa Glu 
                965                 970                 975     


Asn Gly Pro Lys Pro Lys Lys Arg Arg Pro Pro Lys Ala Glu Lys Lys 
            980                 985                 990         


Lys Ala Pro Lys Pro Glu Arg Leu  Pro Pro Ser Met Lys  Gly Lys Ile 
        995                 1000                 1005             


Lys Ser  Lys Ala Ile Ile Ser  Ser Ser Asp Asp Ser  Ser Asp Glu 
    1010                 1015                 1020             


Asp Lys  Leu Lys Ile Ala Asp  Glu Gly His Pro Arg  Asn Ser Asn 
    1025                 1030                 1035             


Ser Asn  Ser Asp Ser Asp Glu  Asp Glu Gln Arg Lys  Lys Cys Ala 
    1040                 1045                 1050             


Ser Ser  Glu Ser Asp Ser Asp  Glu Asn Gln Asn Lys  Ser Gly Ser 
    1055                 1060                 1065             


Glu Ala  Gly Ser Pro Arg Arg  Pro Arg Arg Gln Arg  Ser Asp Gln 
    1070                 1075                 1080             


Asp Ser  Asp Ser Asp Gln Pro  Ser Arg Lys Arg Arg  Pro Ser Gly 
    1085                 1090                 1095             


Ser Glu  Gln Ser Asp Asn Glu  Ser Val Gln Ser Gly  Arg Ser His 
    1100                 1105                 1110             


Ser Gly  Val Ser Glu Asn Asp  Ser Arg Pro Ala Ser  Pro Ser Ala 
    1115                 1120                 1125             


Glu Ser  Asp His Glu Ser Glu  Arg Gly Ser Asp Asn  Glu Gly Ser 
    1130                 1135                 1140             


Gly Gln  Gly Ser Gly Asn Glu  Ser Glu Pro Glu Gly  Ser Asn Asn 
    1145                 1150                 1155             


Glu Ala  Ser Asp Arg Gly Ser  Glu His Gly Ser Asp  Asp Ser Asp 
    1160                 1165                 1170             


<210> 7286
<211> 21
<212> PRT
<213> Homo sapiens

<400> 7286
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro 
            20      


<210> 7287
<211> 32
<212> PRT
<213> Homo sapiens

<400> 7287
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


<210> 7288
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(40)
<223> Selenocysteine

<400> 7288
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Xaa Xaa Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu 
    50                  55  


<210> 7289
<211> 68
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<400> 7289
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Xaa Xaa Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Xaa Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro 
65              


<210> 7290
<211> 70
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<400> 7290
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Xaa Xaa Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Xaa Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln 
65                  70  


<210> 7291
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<400> 7291
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Xaa Xaa Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Xaa Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Xaa Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln 
                85                  90          


<210> 7292
<211> 98
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 7292
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Xaa Xaa Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Xaa Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Xaa Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Xaa Ile 
                85                  90                  95      


Lys Glu 
        


<210> 7293
<211> 101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 7293
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Xaa Xaa Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Xaa Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Xaa Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Xaa Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp 
            100     


<210> 7294
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<400> 7294
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Xaa Xaa Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Xaa Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Xaa Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Xaa Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Xaa Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu 
    130                 135     


<210> 7295
<211> 143
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<400> 7295
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Xaa Xaa Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Xaa Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Xaa Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Xaa Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Xaa Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Xaa Cys Cys Gly 
    130                 135                 140             


<210> 7296
<211> 149
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<400> 7296
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Xaa Xaa Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Xaa Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Xaa Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Xaa Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Xaa Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Xaa Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly 
145                 


<210> 7297
<211> 165
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<400> 7297
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Xaa Xaa Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Xaa Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Xaa Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Xaa Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Xaa Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Xaa Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Xaa Arg Lys 
                165 


<210> 7298
<211> 170
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<400> 7298
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Xaa Xaa Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Xaa Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Xaa Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Xaa Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Xaa Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Xaa Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Xaa Arg Lys Gly Leu Val Ser Gly 
                165                 170 


<210> 7299
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<400> 7299
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Xaa Xaa Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Xaa Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Xaa Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Xaa Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Xaa Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Xaa Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Xaa Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser 
                165                 170                 175 


<210> 7300
<211> 339
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<400> 7300
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Xaa Xaa Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Xaa Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Xaa Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Xaa Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Xaa Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Xaa Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Xaa Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Xaa Gly Glu Gly Asp Xaa Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Xaa Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Xaa Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Xaa Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Xaa Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Xaa Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210> 7301
<211> 110
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<400> 7301
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Xaa Xaa Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Xaa Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Xaa Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Xaa Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Leu 
            100                 105                 110 


<210> 7302
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<400> 7302
Ser Gly Val Tyr Gln His Val Xaa Gly Glu Met Met Gly Gly His Ala 
1               5                   10                  15      


Ile Arg Ile Leu Gly Trp Gly Val Glu Asn Gly Xaa Pro Tyr Trp Leu 
            20                  25                  30          


Val Ala Asn Ser Trp Asn Xaa Asp Trp Gly Asp Asn Gly Phe Phe Lys 
        35                  40                  45              


Ile Leu Arg Gly Gln Asp His Cys Gly Ile Glu Ser Glu Val Val Ala 
    50                  55                  60                  


Gly Ile Pro Arg Xaa Asp Gln Tyr Trp Glu Lys Ile 
65                  70                  75      


<210> 7303
<211> 141
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<400> 7303
Met Gly Ala Gly Pro Ser Leu Leu Leu Ala Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Gly Asp Gly Ala Val Arg Cys Asp Xaa Pro Ala Asn Cys Xaa Tyr 
            20                  25                  30          


Leu Asp Leu Leu Gly Xaa Trp Val Phe Gln Val Gly Ser Ser Gly Ser 
        35                  40                  45              


Gln Arg Asp Val Asn Cys Ser Val Met Gly Pro Gln Glu Lys Lys Val 
    50                  55                  60                  


Val Val Tyr Leu Gln Lys Leu Asp Xaa Ala Tyr Asp Asp Leu Gly Asn 
65                  70                  75                  80  


Ser Gly His Phe Xaa Ile Ile Tyr Asn Gln Gly Phe Glu Ile Val Leu 
                85                  90                  95      


Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Asp Val Xaa Asp Phe Ile 
            100                 105                 110         


Ser His Leu Phe Met Gln Leu Gly Xaa Val Gly Ile Tyr Asp Leu Pro 
        115                 120                 125             


His Leu Arg Asn Lys Leu Ala Met Asn Arg Arg Trp Gly 
    130                 135                 140     


<210> 7304
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<400> 7304
Met Gly Ala Gly Pro Ser Leu Leu Leu Ala Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Gly Asp Gly Ala Val Arg Cys Asp Xaa Pro Ala Asn Cys Xaa Tyr 
            20                  25                  30          


Leu Asp Leu Leu Gly Xaa Trp Val Phe Gln Val Gly Ser Ser Gly Ser 
        35                  40                  45              


Gln Arg Asp Val Asn Cys Ser Val Met Gly Pro Gln Glu Lys Lys Val 
    50                  55                  60                  


Val Val Tyr Leu Gln Lys Leu Asp Xaa Ala Tyr Asp Asp Leu Gly Asn 
65                  70                  75                  80  


Ser Gly His Phe Xaa Ile Ile Tyr Asn Gln Gly Phe Glu Ile Val Leu 
                85                  90                  95      


Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Asp Val Xaa Asp Phe Ile 
            100                 105                 110         


Ser His Leu Phe Met Gln Leu Gly Xaa Val Gly Ile Tyr Asp Leu Pro 
        115                 120                 125             


His Leu Arg Asn Lys Leu Val Ile Lys 
    130                 135         


<210> 7305
<211> 463
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<400> 7305
Met Gly Ala Gly Pro Ser Leu Leu Leu Ala Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Gly Asp Gly Ala Val Arg Cys Asp Xaa Pro Ala Asn Cys Xaa Tyr 
            20                  25                  30          


Leu Asp Leu Leu Gly Xaa Trp Val Phe Gln Val Gly Ser Ser Gly Ser 
        35                  40                  45              


Gln Arg Asp Val Asn Cys Ser Val Met Gly Pro Gln Glu Lys Lys Val 
    50                  55                  60                  


Val Val Tyr Leu Gln Lys Leu Asp Xaa Ala Tyr Asp Asp Leu Gly Asn 
65                  70                  75                  80  


Ser Gly His Phe Xaa Ile Ile Tyr Asn Gln Gly Phe Glu Ile Val Leu 
                85                  90                  95      


Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Tyr Lys Glu Glu Gly Ser 
            100                 105                 110         


Lys Val Xaa Xaa Tyr Cys Asn Glu Xaa Met Xaa Gly Trp Val His Asp 
        115                 120                 125             


Val Leu Gly Arg Asn Trp Ala Cys Phe Xaa Gly Lys Lys Val Gly Xaa 
    130                 135                 140                 


Ala Ser Glu Asn Val Tyr Val Asn Ile Ala His Leu Lys Asn Ser Gln 
145                 150                 155                 160 


Glu Lys Tyr Ser Asn Arg Leu Tyr Lys Tyr Asp His Asn Phe Val Lys 
                165                 170                 175     


Ala Ile Asn Ala Ile Gln Lys Ser Trp Xaa Ala Xaa Xaa Tyr Met Glu 
            180                 185                 190         


Tyr Glu Xaa Leu Xaa Leu Gly Asp Met Ile Arg Arg Ser Gly Gly His 
        195                 200                 205             


Ser Arg Lys Ile Pro Arg Pro Lys Pro Ala Pro Leu Xaa Ala Glu Ile 
    210                 215                 220                 


Gln Gln Lys Ile Leu His Leu Pro Xaa Ser Trp Asp Trp Arg Asn Val 
225                 230                 235                 240 


His Gly Ile Asn Phe Val Ser Pro Val Arg Asn Gln Ala Ser Cys Gly 
                245                 250                 255     


Ser Cys Tyr Ser Phe Ala Ser Met Gly Met Leu Glu Ala Arg Ile Arg 
            260                 265                 270         


Ile Leu Xaa Asn Asn Ser Gln Xaa Pro Ile Leu Ser Pro Gln Glu Val 
        275                 280                 285             


Val Ser Cys Ser Gln Tyr Ala Gln Gly Cys Glu Gly Gly Phe Pro Tyr 
    290                 295                 300                 


Leu Ile Ala Gly Lys Tyr Ala Gln Asp Phe Gly Leu Val Glu Glu Ala 
305                 310                 315                 320 


Cys Phe Pro Tyr Xaa Gly Xaa Asp Ser Pro Cys Lys Met Lys Glu Asp 
                325                 330                 335     


Cys Phe Arg Tyr Tyr Ser Ser Glu Tyr His Tyr Val Gly Gly Phe Tyr 
            340                 345                 350         


Gly Gly Cys Asn Glu Ala Leu Met Lys Leu Glu Leu Val His His Gly 
        355                 360                 365             


Pro Met Ala Val Ala Phe Glu Val Tyr Asp Asp Phe Leu His Tyr Lys 
    370                 375                 380                 


Lys Gly Ile Tyr His His Xaa Gly Leu Arg Asp Pro Phe Asn Pro Phe 
385                 390                 395                 400 


Glu Leu Xaa Asn His Ala Val Leu Leu Val Gly Tyr Gly Xaa Asp Ser 
                405                 410                 415     


Ala Ser Gly Met Asp Tyr Trp Ile Val Lys Asn Ser Trp Gly Xaa Gly 
            420                 425                 430         


Trp Gly Glu Asn Gly Tyr Phe Arg Ile Arg Arg Gly Xaa Asp Glu Cys 
        435                 440                 445             


Ala Ile Glu Ser Ile Ala Val Ala Ala Xaa Pro Ile Pro Lys Leu 
    450                 455                 460             


<210> 7306
<211> 36
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<400> 7306
Xaa Asp Val Xaa Asp Phe Ile Ser His Leu Phe Met Gln Leu Gly Xaa 
1               5                   10                  15      


Val Gly Ile Tyr Asp Leu Pro His Leu Arg Asn Lys Leu Ala Met Asn 
            20                  25                  30          


Arg Arg Trp Gly 
        35      


<210> 7307
<211> 245
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<400> 7307
Xaa Val Val Asp Ser Pro Leu Ala Arg Ser Ala Arg Leu Pro Gly Pro 
1               5                   10                  15      


Gln Glu Lys Lys Val Val Val Tyr Leu Gln Lys Leu Asp Xaa Ala Tyr 
            20                  25                  30          


Asp Asp Leu Gly Asn Ser Gly His Phe Xaa Ile Ile Tyr Asn Gln Gly 
        35                  40                  45              


Phe Glu Ile Val Leu Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Tyr 
    50                  55                  60                  


Lys Glu Glu Gly Ser Lys Val Xaa Xaa Tyr Cys Asn Glu Xaa Met Xaa 
65                  70                  75                  80  


Gly Trp Val His Asp Val Leu Gly Arg Asn Trp Ala Cys Phe Xaa Gly 
                85                  90                  95      


Lys Lys Val Gly Xaa Ala Ser Glu Asn Val Tyr Val Asn Ile Ala His 
            100                 105                 110         


Leu Lys Asn Ser Gln Glu Lys Tyr Ser Asn Arg Leu Tyr Lys Tyr Asp 
        115                 120                 125             


His Asn Phe Val Lys Ala Ile Asn Ala Ile Gln Lys Ser Trp Xaa Ala 
    130                 135                 140                 


Xaa Xaa Tyr Met Glu Tyr Glu Xaa Leu Xaa Leu Gly Asp Met Ile Arg 
145                 150                 155                 160 


Arg Ser Gly Gly His Ser Arg Lys Ile Pro Arg Pro Lys Pro Ala Pro 
                165                 170                 175     


Leu Xaa Ala Glu Ile Gln Gln Lys Ile Leu His Leu Pro Xaa Ser Trp 
            180                 185                 190         


Asp Trp Arg Asn Val His Gly Ile Asn Phe Val Ser Pro Val Arg Asn 
        195                 200                 205             


Gln Ala Ser Cys Gly Ser Cys Tyr Ser Phe Ala Ser Met Gly Met Leu 
    210                 215                 220                 


Glu Ala Arg Ile Arg Ile Leu Xaa Asn Asn Ser Gln Xaa Pro Ile Leu 
225                 230                 235                 240 


Ser Pro Gln Glu Val 
                245 


<210> 7308
<211> 134
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<400> 7308
Met Ala Leu Asn Gln Phe Ser Asp Met Ser Phe Ala Glu Ile Lys His 
1               5                   10                  15      


Lys Tyr Leu Trp Ser Glu Pro Gln Asn Cys Ser Ala Xaa Lys Ser Asn 
            20                  25                  30          


Tyr Leu Arg Gly Xaa Gly Pro Tyr Pro Pro Ser Val Asp Trp Arg Lys 
        35                  40                  45              


Lys Gly Asn Phe Val Ser Pro Val Lys Asn Gln Gly Ala Cys Gly Ser 
    50                  55                  60                  


Cys Trp Xaa Phe Ser Xaa Xaa Gly Ala Leu Glu Ser Ala Ile Ala Ile 
65                  70                  75                  80  


Ala Xaa Gly Lys Met Leu Ser Leu Ala Glu Gln Gln Leu Val Asp Cys 
                85                  90                  95      


Ala Gln Asp Phe Asn Asn His Gly Cys Gln Gly Gly Leu Pro Ser Gln 
            100                 105                 110         


Ala Phe Glu Tyr Ile Leu Tyr Asn Lys Gly Ile Met Gly Glu Asp Xaa 
        115                 120                 125             


Tyr Pro Tyr Gln Gly Lys 
    130                 


<210> 7309
<211> 323
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<400> 7309
Met Trp Ala Xaa Leu Pro Leu Leu Cys Ala Ala Glu Leu Cys Val Asn 
1               5                   10                  15      


Ser Leu Glu Lys Phe His Phe Lys Ser Trp Met Ser Lys His Arg Lys 
            20                  25                  30          


Xaa Tyr Ser Xaa Glu Glu Tyr His His Arg Leu Gln Xaa Phe Ala Ser 
        35                  40                  45              


Asn Trp Arg Lys Ile Asn Ala His Asn Asn Gly Asn His Xaa Phe Lys 
    50                  55                  60                  


Met Ala Leu Asn Gln Phe Ser Asp Met Ser Phe Ala Glu Ile Lys His 
65                  70                  75                  80  


Lys Tyr Leu Trp Ser Glu Pro Gln Asn Cys Ser Ala Xaa Lys Ser Asn 
                85                  90                  95      


Tyr Leu Arg Gly Xaa Gly Pro Tyr Pro Pro Ser Val Asp Trp Arg Lys 
            100                 105                 110         


Lys Gly Asn Phe Val Ser Pro Val Lys Asn Gln Gly Ala Cys Gly Ser 
        115                 120                 125             


Cys Trp Xaa Phe Ser Xaa Xaa Gly Ala Leu Glu Ser Ala Ile Ala Ile 
    130                 135                 140                 


Ala Xaa Gly Lys Met Leu Ser Leu Ala Glu Gln Gln Leu Val Asp Cys 
145                 150                 155                 160 


Ala Gln Asp Phe Asn Asn His Gly Cys Gln Gly Gly Leu Pro Ser Gln 
                165                 170                 175     


Ala Phe Glu Tyr Ile Leu Tyr Asn Lys Gly Ile Met Gly Glu Asp Xaa 
            180                 185                 190         


Tyr Pro Tyr Gln Gly Lys Asp Gly Tyr Cys Lys Phe Gln Pro Gly Lys 
        195                 200                 205             


Ala Ile Gly Phe Val Lys Asp Val Ala Asn Ile Xaa Ile Tyr Asp Glu 
    210                 215                 220                 


Glu Ala Met Val Glu Ala Val Ala Leu Tyr Asn Pro Val Ser Phe Ala 
225                 230                 235                 240 


Phe Glu Val Xaa Gln Asp Phe Met Met Tyr Arg Xaa Gly Ile Tyr Ser 
                245                 250                 255     


Ser Xaa Ser Cys His Lys Xaa Pro Asp Lys Val Asn His Ala Val Leu 
            260                 265                 270         


Ala Val Gly Tyr Gly Glu Lys Asn Gly Ile Pro Tyr Trp Ile Val Lys 
        275                 280                 285             


Asn Ser Trp Gly Pro Gln Trp Gly Met Asn Gly Tyr Phe Leu Ile Glu 
    290                 295                 300                 


Arg Gly Lys Asn Met Cys Gly Leu Ala Ala Cys Ala Ser Tyr Pro Ile 
305                 310                 315                 320 


Pro Leu Val 
            


<210> 7310
<211> 335
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<400> 7310
Met Trp Ala Xaa Leu Pro Leu Leu Cys Ala Gly Ala Trp Leu Leu Gly 
1               5                   10                  15      


Val Pro Val Cys Gly Ala Ala Glu Leu Cys Val Asn Ser Leu Glu Lys 
            20                  25                  30          


Phe His Phe Lys Ser Trp Met Ser Lys His Arg Lys Xaa Tyr Ser Xaa 
        35                  40                  45              


Glu Glu Tyr His His Arg Leu Gln Xaa Phe Ala Ser Asn Trp Arg Lys 
    50                  55                  60                  


Ile Asn Ala His Asn Asn Gly Asn His Xaa Phe Lys Met Ala Leu Asn 
65                  70                  75                  80  


Gln Phe Ser Asp Met Ser Phe Ala Glu Ile Lys His Lys Tyr Leu Trp 
                85                  90                  95      


Ser Glu Pro Gln Asn Cys Ser Ala Xaa Lys Ser Asn Tyr Leu Arg Gly 
            100                 105                 110         


Xaa Gly Pro Tyr Pro Pro Ser Val Asp Trp Arg Lys Lys Gly Asn Phe 
        115                 120                 125             


Val Ser Pro Val Lys Asn Gln Gly Ala Cys Gly Ser Cys Trp Xaa Phe 
    130                 135                 140                 


Ser Xaa Xaa Gly Ala Leu Glu Ser Ala Ile Ala Ile Ala Xaa Gly Lys 
145                 150                 155                 160 


Met Leu Ser Leu Ala Glu Gln Gln Leu Val Asp Cys Ala Gln Asp Phe 
                165                 170                 175     


Asn Asn His Gly Cys Gln Gly Gly Leu Pro Ser Gln Ala Phe Glu Tyr 
            180                 185                 190         


Ile Leu Tyr Asn Lys Gly Ile Met Gly Glu Asp Xaa Tyr Pro Tyr Gln 
        195                 200                 205             


Gly Lys Asp Gly Tyr Cys Lys Phe Gln Pro Gly Lys Ala Ile Gly Phe 
    210                 215                 220                 


Val Lys Asp Val Ala Asn Ile Xaa Ile Tyr Asp Glu Glu Ala Met Val 
225                 230                 235                 240 


Glu Ala Val Ala Leu Tyr Asn Pro Val Ser Phe Ala Phe Glu Val Xaa 
                245                 250                 255     


Gln Asp Phe Met Met Tyr Arg Xaa Gly Ile Tyr Ser Ser Xaa Ser Cys 
            260                 265                 270         


His Lys Xaa Pro Asp Lys Val Asn His Ala Val Leu Ala Val Gly Tyr 
        275                 280                 285             


Gly Glu Lys Asn Gly Ile Pro Tyr Trp Ile Val Lys Asn Ser Trp Gly 
    290                 295                 300                 


Pro Gln Trp Gly Met Asn Gly Tyr Phe Leu Ile Glu Arg Gly Lys Asn 
305                 310                 315                 320 


Met Cys Gly Leu Ala Ala Cys Ala Ser Tyr Pro Ile Pro Leu Val 
                325                 330                 335 


<210> 7311
<211> 62
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<400> 7311
Met Trp Ala Xaa Leu Pro Leu Leu Cys Ala Gly Ala Trp Leu Leu Gly 
1               5                   10                  15      


Val Pro Val Cys Gly Ala Ala Glu Leu Cys Val Asn Ser Leu Glu Lys 
            20                  25                  30          


Phe His Phe Lys Ser Trp Met Ser Lys Lys Xaa Lys Ala His Cys Val 
        35                  40                  45              


Leu Val Ala Glu Ser Val Gly Glu His Gln Cys Met Cys Phe 
    50                  55                  60          


<210> 7312
<211> 41
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<400> 7312
Met Trp Ala Xaa Leu Pro Leu Leu Cys Ala Gly Ala Trp Leu Leu Gly 
1               5                   10                  15      


Val Pro Val Cys Gly Ala Ala Glu Leu Cys Val Asn Ser Leu Gly Xaa 
            20                  25                  30          


Gln Arg Ala Arg Arg Pro Arg Gly Cys 
        35                  40      


<210> 7313
<211> 118
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 7313
Met Trp Ala Xaa Leu Pro Leu Leu Cys Ala Gly Ala Trp Leu Leu Gly 
1               5                   10                  15      


Val Pro Val Cys Gly Ala Ala Glu Leu Cys Val Asn Ser Leu Val Ala 
            20                  25                  30          


Gly Leu Ser Pro Pro Leu Gly Pro Trp Ser Leu Arg Ser Pro Ser Gln 
        35                  40                  45              


Pro Glu Arg Cys Cys Pro Trp Arg Asn Ser Ser Trp Trp Xaa Ala Pro 
    50                  55                  60                  


Arg Xaa Ser Ile Ile Xaa Ala Ala Lys Gly Val Ser Pro Ala Arg Leu 
65                  70                  75                  80  


Ser Ser Ile Ser Cys Xaa Xaa Arg Gly Ser Trp Val Lys Xaa Pro Xaa 
                85                  90                  95      


Pro Xaa Arg Ala Arg Met Val Ile Ala Ser Ser Asn Leu Glu Arg Pro 
            100                 105                 110         


Ser Ala Leu Ser Arg Met 
        115             


<210> 7314
<211> 258
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<400> 7314
Met His Lys Glu Asn Glu Glu Ile Tyr Asn Val Ser Glu Asn Arg Lys 
1               5                   10                  15      


His Cys Pro Ile Phe Pro Cys Pro Leu Leu Xaa Arg Ser Gly Lys Val 
            20                  25                  30          


Pro Glu Phe Arg His Glu Arg Glu Glu Arg Leu Glu Glu Met Ile Arg 
        35                  40                  45              


Arg Gln Asn Leu Asp Gly Asn Leu Ser Phe Val Met Trp Gly Leu Lys 
    50                  55                  60                  


Val Leu Leu Leu Pro Val Val Ser Phe Ala Leu Tyr Pro Glu Glu Ile 
65                  70                  75                  80  


Leu Asp Xaa His Trp Glu Leu Trp Lys Lys Xaa His Arg Lys Gln Tyr 
                85                  90                  95      


Asn Asn Lys Val Asp Glu Ile Ser Arg Arg Leu Ile Trp Glu Lys Asn 
            100                 105                 110         


Leu Lys Tyr Ile Ser Ile His Asn Leu Glu Ala Ser Leu Gly Val His 
        115                 120                 125             


Xaa Tyr Glu Leu Ala Met Asn His Leu Gly Asp Met Xaa Ser Glu Glu 
    130                 135                 140                 


Val Val Gln Lys Met Xaa Gly Leu Lys Val Pro Leu Ser His Ser Arg 
145                 150                 155                 160 


Ser Asn Asp Xaa Leu Tyr Ile Pro Glu Trp Glu Gly Arg Ala Pro Asp 
                165                 170                 175     


Ser Val Asp Tyr Arg Lys Lys Gly Tyr Val Xaa Pro Val Lys Asn Gln 
            180                 185                 190         


Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ser Val Gly Ala Leu Glu 
        195                 200                 205             


Gly Gln Leu Lys Lys Lys Xaa Gly Lys Leu Leu Asn Leu Ser Pro Gln 
    210                 215                 220                 


Asn Leu Val Asp Cys Val Ser Glu Asn Asp Gly Cys Gly Gly Gly Tyr 
225                 230                 235                 240 


Met Xaa Asn Ala Phe Gln Tyr Val Gln Lys Asn Arg Gly Ile Asp Ser 
                245                 250                 255     


Glu Asp 
        


<210> 7315
<211> 329
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<400> 7315
Met Trp Gly Leu Lys Val Leu Leu Leu Pro Val Val Ser Phe Ala Leu 
1               5                   10                  15      


Tyr Pro Glu Glu Ile Leu Asp Xaa His Trp Glu Leu Trp Lys Lys Xaa 
            20                  25                  30          


His Arg Lys Gln Tyr Asn Asn Lys Val Asp Glu Ile Ser Arg Arg Leu 
        35                  40                  45              


Ile Trp Glu Lys Asn Leu Lys Tyr Ile Ser Ile His Asn Leu Glu Ala 
    50                  55                  60                  


Ser Leu Gly Val His Xaa Tyr Glu Leu Ala Met Asn His Leu Gly Asp 
65                  70                  75                  80  


Met Xaa Ser Glu Glu Val Val Gln Lys Met Xaa Gly Leu Lys Val Pro 
                85                  90                  95      


Leu Ser His Ser Arg Ser Asn Asp Xaa Leu Tyr Ile Pro Glu Trp Glu 
            100                 105                 110         


Gly Arg Ala Pro Asp Ser Val Asp Tyr Arg Lys Lys Gly Tyr Val Xaa 
        115                 120                 125             


Pro Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ser 
    130                 135                 140                 


Val Gly Ala Leu Glu Gly Gln Leu Lys Lys Lys Xaa Gly Lys Leu Leu 
145                 150                 155                 160 


Asn Leu Ser Pro Gln Asn Leu Val Asp Cys Val Ser Glu Asn Asp Gly 
                165                 170                 175     


Cys Gly Gly Gly Tyr Met Xaa Asn Ala Phe Gln Tyr Val Gln Lys Asn 
            180                 185                 190         


Arg Gly Ile Asp Ser Glu Asp Ala Tyr Pro Tyr Val Gly Gln Glu Glu 
        195                 200                 205             


Ser Cys Met Tyr Asn Pro Xaa Gly Lys Ala Ala Lys Cys Arg Gly Tyr 
    210                 215                 220                 


Arg Glu Ile Pro Glu Gly Asn Glu Lys Ala Leu Lys Arg Ala Val Ala 
225                 230                 235                 240 


Arg Val Gly Pro Val Ser Val Ala Ile Asp Ala Ser Leu Xaa Ser Phe 
                245                 250                 255     


Gln Phe Tyr Ser Lys Gly Val Tyr Tyr Asp Glu Ser Cys Asn Ser Asp 
            260                 265                 270         


Asn Leu Asn His Ala Val Leu Ala Val Gly Tyr Gly Ile Gln Lys Gly 
        275                 280                 285             


Asn Lys His Trp Ile Ile Lys Asn Ser Trp Gly Glu Asn Trp Gly Asn 
    290                 295                 300                 


Lys Gly Tyr Ile Leu Met Ala Arg Asn Lys Asn Asn Ala Cys Gly Ile 
305                 310                 315                 320 


Ala Asn Leu Ala Ser Phe Pro Lys Met 
                325                 


<210> 7316
<211> 333
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<400> 7316
Met Asn Pro Xaa Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Xaa Leu Xaa Phe Asp His Ser Leu Glu Ala Gln Trp Xaa Lys Trp 
            20                  25                  30          


Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln 
    50                  55                  60                  


Glu Tyr Arg Glu Gly Lys His Ser Phe Xaa Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Xaa Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln 
                85                  90                  95      


Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr 
            100                 105                 110         


Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Xaa Pro 
        115                 120                 125             


Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Xaa 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Xaa Gly Arg Leu Ile Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu 
                165                 170                 175     


Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Xaa Glu 
        195                 200                 205             


Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Xaa Gly 
    210                 215                 220                 


Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala 
225                 230                 235                 240 


Xaa Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe 
                245                 250                 255     


Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu 
            260                 265                 270         


Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Xaa 
        275                 280                 285             


Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu 
    290                 295                 300                 


Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn 
305                 310                 315                 320 


His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Xaa Val 
                325                 330             


<210> 7317
<211> 225
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<400> 7317
Met Asn Pro Xaa Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Xaa Leu Xaa Phe Asp His Ser Leu Glu Ala Gln Trp Xaa Lys Trp 
            20                  25                  30          


Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln 
    50                  55                  60                  


Glu Tyr Arg Glu Gly Lys His Ser Phe Xaa Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Xaa Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln 
                85                  90                  95      


Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr 
            100                 105                 110         


Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Xaa Pro 
        115                 120                 125             


Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Xaa 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Xaa Gly Arg Leu Ile Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu 
                165                 170                 175     


Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Xaa Val 
        195                 200                 205             


Ser Gly Ala Pro Cys His His Ser Ser Ser Ala Phe Gly Arg Trp Xaa 
    210                 215                 220                 


Leu 
225 


<210> 7318
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<400> 7318
Ile Ile Asp Asn Lys Gly Ile Asp Ser Asp Ala Ser Tyr Pro Tyr Lys 
1               5                   10                  15      


Ala Met Asp Gln Lys Cys Gln Tyr Asp Ser Lys Tyr Arg Ala Ala Xaa 
            20                  25                  30          


Cys Ser Lys Tyr Xaa Glu Leu Pro Tyr Gly Arg Glu Asp Val Leu Lys 
        35                  40                  45              


Glu Ala Val Ala Asn Lys Gly Pro Val Ser Val Gly Val Asp Ala Arg 
    50                  55                  60                  


His Pro Ser Phe Phe Leu Tyr Arg Ser Asp Gly Val Leu Leu Cys Cys 
65                  70                  75                  80  


Gln Ala Gly Val Arg Trp His Asp Leu Ser Ser Leu Gln Pro Leu Pro 
                85                  90                  95      


Pro Gly Phe Lys Gln Phe Ser Cys Leu Ser Leu Leu Ser Ser Trp Asp 
            100                 105                 110         


Tyr Arg Cys Leu Leu 
        115         


<210> 7319
<211> 281
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<400> 7319
Met Lys Arg Leu Val Cys Val Leu Leu Val Cys Ser Ser Ala Val Ala 
1               5                   10                  15      


Gln Leu His Lys Asp Pro Xaa Leu Asp His His Trp His Leu Trp Lys 
            20                  25                  30          


Lys Xaa Tyr Gly Lys Gln Tyr Lys Glu Lys Asn Glu Glu Ala Val Arg 
        35                  40                  45              


Arg Leu Ile Trp Glu Lys Asn Leu Lys Phe Val Met Leu His Asn Leu 
    50                  55                  60                  


Glu His Ser Met Gly Met His Ser Tyr Asp Leu Gly Met Asn His Leu 
65                  70                  75                  80  


Gly Asp Met Gly Ser Cys Gly Ala Cys Trp Ala Phe Ser Ala Val Gly 
                85                  90                  95      


Ala Leu Glu Ala Gln Leu Lys Leu Lys Xaa Gly Lys Leu Val Ser Leu 
            100                 105                 110         


Ser Ala Gln Asn Leu Val Asp Cys Ser Xaa Glu Lys Tyr Gly Asn Lys 
        115                 120                 125             


Gly Cys Asn Gly Gly Phe Met Xaa Xaa Ala Phe Gln Tyr Ile Ile Asp 
    130                 135                 140                 


Asn Lys Gly Ile Asp Ser Asp Ala Ser Tyr Pro Tyr Lys Ala Met Asp 
145                 150                 155                 160 


Gln Lys Cys Gln Tyr Asp Ser Lys Tyr Arg Ala Ala Xaa Cys Ser Lys 
                165                 170                 175     


Tyr Xaa Glu Leu Pro Tyr Gly Arg Glu Asp Val Leu Lys Glu Ala Val 
            180                 185                 190         


Ala Asn Lys Gly Pro Val Ser Val Gly Val Asp Ala Arg His Pro Ser 
        195                 200                 205             


Phe Phe Leu Tyr Arg Ser Gly Val Tyr Tyr Glu Pro Ser Cys Xaa Gln 
    210                 215                 220                 


Asn Val Asn His Gly Val Leu Val Val Gly Tyr Gly Asp Leu Asn Gly 
225                 230                 235                 240 


Lys Glu Tyr Trp Leu Val Lys Asn Ser Trp Gly His Asn Phe Gly Glu 
                245                 250                 255     


Glu Gly Tyr Ile Arg Met Ala Arg Asn Lys Gly Asn His Cys Gly Ile 
            260                 265                 270         


Ala Ser Phe Pro Ser Tyr Pro Glu Ile 
        275                 280     


<210> 7320
<211> 331
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<400> 7320
Met Lys Arg Leu Val Cys Val Leu Leu Val Cys Ser Ser Ala Val Ala 
1               5                   10                  15      


Gln Leu His Lys Asp Pro Xaa Leu Asp His His Trp His Leu Trp Lys 
            20                  25                  30          


Lys Xaa Tyr Gly Lys Gln Tyr Lys Glu Lys Asn Glu Glu Ala Val Arg 
        35                  40                  45              


Arg Leu Ile Trp Glu Lys Asn Leu Lys Phe Val Met Leu His Asn Leu 
    50                  55                  60                  


Glu His Ser Met Gly Met His Ser Tyr Asp Leu Gly Met Asn His Leu 
65                  70                  75                  80  


Gly Asp Met Xaa Ser Glu Glu Val Met Ser Leu Met Ser Ser Leu Arg 
                85                  90                  95      


Val Pro Ser Gln Trp Gln Arg Asn Ile Xaa Tyr Lys Ser Asn Pro Asn 
            100                 105                 110         


Arg Ile Leu Pro Asp Ser Val Asp Trp Arg Glu Lys Gly Cys Val Xaa 
        115                 120                 125             


Glu Val Lys Tyr Gln Gly Ser Cys Gly Ala Cys Trp Ala Phe Ser Ala 
    130                 135                 140                 


Val Gly Ala Leu Glu Ala Gln Leu Lys Leu Lys Xaa Gly Lys Leu Val 
145                 150                 155                 160 


Ser Leu Ser Ala Gln Asn Leu Val Asp Cys Ser Xaa Glu Lys Tyr Gly 
                165                 170                 175     


Asn Lys Gly Cys Asn Gly Gly Phe Met Xaa Xaa Ala Phe Gln Tyr Ile 
            180                 185                 190         


Ile Asp Asn Lys Gly Ile Asp Ser Asp Ala Ser Tyr Pro Tyr Lys Ala 
        195                 200                 205             


Met Asp Gln Lys Cys Gln Tyr Asp Ser Lys Tyr Arg Ala Ala Xaa Cys 
    210                 215                 220                 


Ser Lys Tyr Xaa Glu Leu Pro Tyr Gly Arg Glu Asp Val Leu Lys Glu 
225                 230                 235                 240 


Ala Val Ala Asn Lys Gly Pro Val Ser Val Gly Val Asp Ala Arg His 
                245                 250                 255     


Pro Ser Phe Phe Leu Tyr Arg Ser Gly Val Tyr Tyr Glu Pro Ser Cys 
            260                 265                 270         


Xaa Gln Asn Val Asn His Gly Val Leu Val Val Gly Tyr Gly Asp Leu 
        275                 280                 285             


Asn Gly Lys Glu Tyr Trp Leu Val Lys Asn Ser Trp Gly His Asn Phe 
    290                 295                 300                 


Gly Glu Glu Gly Tyr Ile Arg Met Ala Arg Asn Lys Gly Asn His Cys 
305                 310                 315                 320 


Gly Ile Ala Ser Phe Pro Ser Tyr Pro Glu Ile 
                325                 330     


<210> 7321
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<400> 7321
Xaa Val Leu Lys Glu Ala Val Ala Asn Lys Gly Pro Val Ser Val Gly 
1               5                   10                  15      


Val Asp Ala Arg His Pro Ser Phe Phe Leu Tyr Arg Ser Gly Val Tyr 
            20                  25                  30          


Tyr Glu Pro Ser Cys Xaa Gln Asn Val Asn His Gly Val Leu Val Val 
        35                  40                  45              


Gly Tyr Gly Asp Leu Asn Gly Lys Glu Tyr Trp Leu Val Lys Asn Ser 
    50                  55                  60                  


Trp Gly His Asn Phe Gly Glu Glu Gly Tyr Ile Arg Met Ala Arg Asn 
65                  70                  75                  80  


Lys Gly Asn His Cys Gly Ile Ala Ser Phe Pro Ser Tyr Pro Glu Ile 
                85                  90                  95      


<210> 7322
<211> 513
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<400> 7322
Met Trp Lys Ala Ser Ala Gly His Ala Val Ser Ile Ala Gln Asp Asp 
1               5                   10                  15      


Ala Gly Ala Asp Asp Trp Glu Xaa Asp Pro Asp Phe Val Asn Asp Val 
            20                  25                  30          


Ser Glu Lys Glu Gln Arg Trp Gly Ala Lys Xaa Val Gln Gly Ser Gly 
        35                  40                  45              


His Gln Glu His Ile Asn Ile His Lys Leu Arg Glu Asn Val Phe Gln 
    50                  55                  60                  


Glu His Gln Xaa Leu Lys Glu Lys Glu Leu Glu Xaa Gly Pro Lys Ala 
65                  70                  75                  80  


Ser His Gly Tyr Gly Gly Lys Phe Gly Val Glu Gln Asp Arg Met Asp 
                85                  90                  95      


Lys Ser Ala Val Gly His Glu Tyr Gln Ser Lys Leu Ser Lys His Cys 
            100                 105                 110         


Ser Gln Val Asp Ser Val Arg Gly Phe Gly Gly Lys Phe Gly Val Gln 
        115                 120                 125             


Met Asp Arg Val Asp Gln Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys 
    130                 135                 140                 


Xaa Glu Lys His Ala Ser Gln Lys Asp Tyr Ser Ser Gly Phe Gly Gly 
145                 150                 155                 160 


Lys Tyr Gly Val Gln Ala Asp Arg Val Asp Lys Ser Ala Val Gly Phe 
                165                 170                 175     


Asp Tyr Gln Gly Lys Xaa Glu Lys His Glu Ser Gln Arg Asp Tyr Ser 
            180                 185                 190         


Lys Gly Phe Gly Gly Lys Tyr Gly Ile Asp Lys Asp Lys Val Asp Lys 
        195                 200                 205             


Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys Xaa Glu Lys His Glu Ser 
    210                 215                 220                 


Gln Lys Asp Tyr Val Lys Gly Phe Gly Gly Lys Phe Gly Val Gln Xaa 
225                 230                 235                 240 


Asp Arg Gln Asp Lys Cys Ala Leu Gly Trp Asp His Gln Glu Lys Leu 
                245                 250                 255     


Gln Leu His Glu Ser Gln Lys Asp Tyr Ser Lys Gly Phe Gly Gly Lys 
            260                 265                 270         


Tyr Gly Val Gln Lys Asp Arg Met Asp Lys Asn Ala Ser Xaa Phe Glu 
        275                 280                 285             


Asp Val Xaa Gln Val Ser Ser Ala Tyr Gln Lys Xaa Val Pro Val Glu 
    290                 295                 300                 


Ala Val Xaa Ser Lys Xaa Ser Asn Ile Arg Ala Asn Phe Glu Asn Leu 
305                 310                 315                 320 


Ala Lys Glu Lys Glu Gln Glu Asp Arg Arg Lys Ala Glu Ala Glu Arg 
                325                 330                 335     


Ala Gln Arg Met Ala Lys Glu Arg Gln Glu Gln Glu Glu Ala Arg Arg 
            340                 345                 350         


Lys Leu Glu Glu Gln Ala Arg Ala Lys Xaa Gln Xaa Pro Pro Val Ser 
        355                 360                 365             


Pro Ala Pro Gln Pro Xaa Glu Glu Arg Leu Pro Ser Ser Pro Val Tyr 
    370                 375                 380                 


Glu Asp Ala Ala Ser Phe Lys Ala Glu Leu Ser Tyr Arg Gly Pro Val 
385                 390                 395                 400 


Ser Gly Xaa Glu Pro Glu Pro Val Tyr Ser Met Glu Ala Ala Asp Tyr 
                405                 410                 415     


Arg Glu Ala Ser Ser Gln Gln Gly Leu Ala Tyr Ala Xaa Glu Ala Val 
            420                 425                 430         


Tyr Glu Ser Ala Glu Ala Pro Gly His Tyr Pro Ala Glu Asp Ser Xaa 
        435                 440                 445             


Tyr Asp Glu Tyr Glu Asn Asp Leu Gly Ile Xaa Ala Val Ala Leu Tyr 
    450                 455                 460                 


Asp Tyr Gln Ala Ala Gly Asp Asp Glu Ile Ser Phe Asp Pro Asp Asp 
465                 470                 475                 480 


Ile Ile Xaa Asn Ile Glu Met Ile Asp Asp Gly Trp Trp Arg Gly Val 
                485                 490                 495     


Cys Lys Gly Arg Tyr Gly Leu Phe Pro Ala Asn Tyr Val Glu Leu Arg 
            500                 505                 510         


Gln 
    


<210> 7323
<211> 550
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<400> 7323
Met Trp Lys Ala Ser Ala Gly His Ala Val Ser Ile Ala Gln Asp Asp 
1               5                   10                  15      


Ala Gly Ala Asp Asp Trp Glu Xaa Asp Pro Asp Phe Val Asn Asp Val 
            20                  25                  30          


Ser Glu Lys Glu Gln Arg Trp Gly Ala Lys Xaa Val Gln Gly Ser Gly 
        35                  40                  45              


His Gln Glu His Ile Asn Ile His Lys Leu Arg Glu Asn Val Phe Gln 
    50                  55                  60                  


Glu His Gln Xaa Leu Lys Glu Lys Glu Leu Glu Xaa Gly Pro Lys Ala 
65                  70                  75                  80  


Ser His Gly Tyr Gly Gly Lys Phe Gly Val Glu Gln Asp Arg Met Asp 
                85                  90                  95      


Lys Ser Ala Val Gly His Glu Tyr Gln Ser Lys Leu Ser Lys His Cys 
            100                 105                 110         


Ser Gln Val Asp Ser Val Arg Gly Phe Gly Gly Lys Phe Gly Val Gln 
        115                 120                 125             


Met Asp Arg Val Asp Gln Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys 
    130                 135                 140                 


Xaa Glu Lys His Ala Ser Gln Lys Asp Tyr Ser Ser Gly Phe Gly Gly 
145                 150                 155                 160 


Lys Tyr Gly Val Gln Ala Asp Arg Val Asp Lys Ser Ala Val Gly Phe 
                165                 170                 175     


Asp Tyr Gln Gly Lys Xaa Glu Lys His Glu Ser Gln Arg Asp Tyr Ser 
            180                 185                 190         


Lys Gly Phe Gly Gly Lys Tyr Gly Ile Asp Lys Asp Lys Val Asp Lys 
        195                 200                 205             


Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys Xaa Glu Lys His Glu Ser 
    210                 215                 220                 


Gln Lys Asp Tyr Val Lys Gly Phe Gly Gly Lys Phe Gly Val Gln Xaa 
225                 230                 235                 240 


Asp Arg Gln Asp Lys Cys Ala Leu Gly Trp Asp His Gln Glu Lys Leu 
                245                 250                 255     


Gln Leu His Glu Ser Gln Lys Asp Tyr Lys Xaa Gly Phe Gly Gly Lys 
            260                 265                 270         


Phe Gly Val Gln Ser Glu Arg Gln Asp Ser Ala Ala Val Gly Phe Asp 
        275                 280                 285             


Tyr Lys Glu Lys Leu Ala Lys His Glu Ser Gln Gln Asp Tyr Ser Lys 
    290                 295                 300                 


Gly Phe Gly Gly Lys Tyr Gly Val Gln Lys Asp Arg Met Asp Lys Asn 
305                 310                 315                 320 


Ala Ser Xaa Phe Glu Asp Val Xaa Gln Val Ser Ser Ala Tyr Gln Lys 
                325                 330                 335     


Xaa Val Pro Val Glu Ala Val Xaa Ser Lys Xaa Ser Asn Ile Arg Ala 
            340                 345                 350         


Asn Phe Glu Asn Leu Ala Lys Glu Lys Glu Gln Glu Asp Arg Arg Lys 
        355                 360                 365             


Ala Glu Ala Glu Arg Ala Gln Arg Met Ala Lys Glu Arg Gln Glu Gln 
    370                 375                 380                 


Glu Glu Ala Arg Arg Lys Leu Glu Glu Gln Ala Arg Ala Lys Xaa Gln 
385                 390                 395                 400 


Xaa Pro Pro Val Ser Pro Ala Pro Gln Pro Xaa Glu Glu Arg Leu Pro 
                405                 410                 415     


Ser Ser Pro Val Tyr Glu Asp Ala Ala Ser Phe Lys Ala Glu Leu Ser 
            420                 425                 430         


Tyr Arg Gly Pro Val Ser Gly Xaa Glu Pro Glu Pro Val Tyr Ser Met 
        435                 440                 445             


Glu Ala Ala Asp Tyr Arg Glu Ala Ser Ser Gln Gln Gly Leu Ala Tyr 
    450                 455                 460                 


Ala Xaa Glu Ala Val Tyr Glu Ser Ala Glu Ala Pro Gly His Tyr Pro 
465                 470                 475                 480 


Ala Glu Asp Ser Xaa Tyr Asp Glu Tyr Glu Asn Asp Leu Gly Ile Xaa 
                485                 490                 495     


Ala Val Ala Leu Tyr Asp Tyr Gln Ala Ala Gly Asp Asp Glu Ile Ser 
            500                 505                 510         


Phe Asp Pro Asp Asp Ile Ile Xaa Asn Ile Glu Met Ile Asp Asp Gly 
        515                 520                 525             


Trp Trp Arg Gly Val Cys Lys Gly Arg Tyr Gly Leu Phe Pro Ala Asn 
    530                 535                 540                 


Tyr Val Glu Leu Arg Gln 
545                 550 


<210> 7324
<211> 634
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<400> 7324
Met Trp Lys Ala Ser Ala Gly His Ala Val Ser Ile Ala Gln Asp Asp 
1               5                   10                  15      


Ala Gly Ala Asp Asp Trp Glu Xaa Asp Pro Asp Phe Val Asn Asp Val 
            20                  25                  30          


Ser Glu Lys Glu Gln Arg Trp Gly Ala Lys Xaa Val Gln Gly Ser Gly 
        35                  40                  45              


His Gln Glu His Ile Asn Ile His Lys Leu Arg Glu Asn Val Phe Gln 
    50                  55                  60                  


Glu His Gln Xaa Leu Lys Glu Lys Glu Leu Glu Xaa Gly Pro Lys Ala 
65                  70                  75                  80  


Ser His Gly Tyr Gly Gly Lys Phe Gly Val Glu Gln Asp Arg Met Asp 
                85                  90                  95      


Lys Ser Ala Val Gly His Glu Tyr Gln Ser Lys Leu Ser Lys His Cys 
            100                 105                 110         


Ser Gln Val Asp Ser Val Arg Gly Phe Gly Gly Lys Phe Gly Val Gln 
        115                 120                 125             


Met Asp Arg Val Asp Gln Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys 
    130                 135                 140                 


Xaa Glu Lys His Ala Ser Gln Lys Asp Tyr Ser Ser Gly Phe Gly Gly 
145                 150                 155                 160 


Lys Tyr Gly Val Gln Ala Asp Arg Val Asp Lys Ser Ala Val Gly Phe 
                165                 170                 175     


Asp Tyr Gln Gly Lys Xaa Glu Lys His Glu Ser Gln Arg Asp Tyr Ser 
            180                 185                 190         


Lys Gly Phe Gly Gly Lys Tyr Gly Ile Asp Lys Asp Lys Val Asp Lys 
        195                 200                 205             


Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys Xaa Glu Lys His Glu Ser 
    210                 215                 220                 


Gln Lys Asp Tyr Val Lys Gly Phe Gly Gly Lys Phe Gly Val Gln Xaa 
225                 230                 235                 240 


Asp Arg Gln Asp Lys Cys Ala Leu Gly Trp Asp His Gln Glu Lys Leu 
                245                 250                 255     


Gln Leu His Glu Ser Gln Lys Asp Tyr Ser Lys Gly Phe Gly Gly Lys 
            260                 265                 270         


Tyr Gly Val Gln Lys Asp Arg Met Asp Lys Asn Ala Ser Xaa Phe Glu 
        275                 280                 285             


Asp Val Xaa Gln Val Ser Ser Ala Tyr Gln Lys Xaa Val Pro Val Glu 
    290                 295                 300                 


Ala Val Xaa Ser Lys Xaa Ser Asn Ile Arg Ala Asn Phe Glu Asn Leu 
305                 310                 315                 320 


Ala Lys Glu Lys Glu Gln Glu Asp Arg Arg Lys Ala Glu Ala Glu Arg 
                325                 330                 335     


Ala Gln Arg Met Ala Lys Glu Arg Gln Glu Gln Glu Glu Ala Arg Arg 
            340                 345                 350         


Lys Leu Glu Glu Gln Ala Arg Ala Lys Xaa Gln Xaa Pro Pro Val Ser 
        355                 360                 365             


Pro Ala Pro Gln Pro Xaa Glu Glu Arg Leu Pro Ser Ser Pro Val Tyr 
    370                 375                 380                 


Glu Asp Ala Ala Ser Phe Lys Ala Glu Leu Ser Tyr Arg Gly Pro Val 
385                 390                 395                 400 


Ser Gly Xaa Glu Pro Glu Pro Val Tyr Ser Met Glu Ala Ala Asp Tyr 
                405                 410                 415     


Arg Glu Ala Ser Ser Gln Gln Gly Leu Ala Tyr Ala Xaa Glu Ala Val 
            420                 425                 430         


Tyr Glu Ser Ala Glu Ala Pro Gly His Tyr Pro Ala Glu Asp Ser Xaa 
        435                 440                 445             


Tyr Asp Glu Tyr Glu Asn Asp Leu Gly Ile Xaa Ala Val Ala Leu Tyr 
    450                 455                 460                 


Asp Tyr Gln Ala Ala Gly Asp Asp Glu Ile Ser Phe Asp Pro Asp Asp 
465                 470                 475                 480 


Ile Ile Xaa Asn Ile Glu Met Ile Asp Asp Gly Trp Trp Arg Gly Val 
                485                 490                 495     


Cys Lys Gly Arg Phe Arg Glu Leu Ala Phe Ser Cys Val Arg Val Ala 
            500                 505                 510         


Leu Val Pro Ile Lys Cys Ser Arg Asp Leu Pro Gly Gln Ala Arg Gly 
        515                 520                 525             


Leu Arg Ser Ala Leu Trp Arg Val Gly Arg Lys Asp Cys Pro Arg Arg 
    530                 535                 540                 


Gly Ala Ser Ser Arg Val Ser Leu Leu Gly Arg Arg Gly Leu Gly Leu 
545                 550                 555                 560 


Met Glu Val Asn Pro Glu Leu Ser His Pro Glu His Arg Ser Cys His 
                565                 570                 575     


Val Arg Trp Glu Ile Cys Leu Cys His Xaa Val Xaa Ala Arg Arg Ile 
            580                 585                 590         


Arg Lys Leu Ile Ser Phe Leu Arg Ser Arg Glu Ala Gly Pro Val Pro 
        595                 600                 605             


Ser Cys Ser Gln Val Gly Gly Val Ser Phe Gln Lys Val Xaa Trp Lys 
    610                 615                 620                 


Cys Leu Gly Xaa Trp Val Pro Glu Cys Pro 
625                 630                 


<210> 7325
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<400> 7325
Arg Lys Ala Glu Ala Glu Arg Ala Gln Arg Met Ala Lys Glu Arg Gln 
1               5                   10                  15      


Glu Gln Glu Glu Ala Arg Arg Lys Leu Glu Glu Gln Ala Arg Ala Lys 
            20                  25                  30          


Xaa Gln Xaa Pro Pro Val Ser Pro Ala Pro Gln Pro Xaa Glu Glu Arg 
        35                  40                  45              


Leu Pro Ser Ser Pro Val Tyr Glu Asp Ala Ala Ser Phe Lys Ala Glu 
    50                  55                  60                  


Leu Ser Tyr Arg Gly Pro Val Ser Gly Xaa Glu Pro Glu Pro Val Tyr 
65                  70                  75                  80  


Ser Met Glu Ala Ala Asp Tyr Arg Glu Ala Ser Ser Gln Gln Gly Leu 
                85                  90                  95      


Ala Tyr Ala Xaa Glu Ala Val Tyr Glu Ser Ala Glu Ala Pro Gly His 
            100                 105                 110         


Tyr Pro Ala Ala Leu Ser Trp Leu Ser Phe Arg Gly Gln His Leu Arg 
        115                 120                 125             


<210> 7326
<211> 265
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<400> 7326
Xaa Ser Lys Xaa Ser Asn Ile Arg Ala Asn Phe Glu Asn Leu Ala Lys 
1               5                   10                  15      


Glu Lys Glu Gln Glu Asp Arg Arg Lys Ala Glu Ala Glu Arg Ala Gln 
            20                  25                  30          


Arg Met Ala Lys Glu Arg Gln Glu Gln Glu Glu Ala Arg Arg Lys Leu 
        35                  40                  45              


Glu Glu Gln Ala Arg Ala Lys Xaa Gln Xaa Pro Pro Val Ser Pro Ala 
    50                  55                  60                  


Pro Gln Pro Xaa Glu Glu Arg Leu Pro Ser Ser Pro Val Tyr Glu Asp 
65                  70                  75                  80  


Ala Ala Ser Phe Lys Ala Glu Leu Ser Tyr Arg Gly Pro Val Ser Gly 
                85                  90                  95      


Xaa Glu Pro Glu Pro Val Tyr Ser Met Glu Ala Ala Asp Tyr Arg Glu 
            100                 105                 110         


Ala Ser Ser Gln Gln Gly Leu Ala Tyr Ala Xaa Glu Ala Val Tyr Glu 
        115                 120                 125             


Ser Ala Glu Ala Pro Gly His Tyr Pro Ala Glu Asp Ser Xaa Tyr Asp 
    130                 135                 140                 


Glu Tyr Glu Asn Asp Leu Gly Ile Xaa Ala Val Ala Leu Tyr Asp Tyr 
145                 150                 155                 160 


Gln Ala Ala Gly Asp Asp Glu Ile Ser Phe Asp Pro Asp Asp Ile Ile 
                165                 170                 175     


Xaa Asn Ile Glu Met Ile Asp Asp Gly Trp Trp Arg Gly Val Cys Lys 
            180                 185                 190         


Gly Arg Phe Arg Glu Leu Ala Phe Ser Cys Val Arg Val Ala Leu Val 
        195                 200                 205             


Pro Ile Lys Cys Ser Arg Asp Leu Pro Gly Gln Ala Arg Gly Leu Arg 
    210                 215                 220                 


Lys Leu Ile Ser Phe Leu Arg Ser Arg Glu Ala Gly Pro Val Pro Ser 
225                 230                 235                 240 


Cys Ser Gln Val Gly Gly Val Ser Phe Gln Lys Val Xaa Trp Lys Cys 
                245                 250                 255     


Leu Gly Xaa Trp Val Pro Glu Cys Pro 
            260                 265 


<210> 7327
<211> 752
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(502)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (712)..(712)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<400> 7327
Met Ser Ser Xaa Arg Ser Gln Asn Pro His Gly Leu Lys Gln Ile Gly 
1               5                   10                  15      


Leu Asp Gln Ile Trp Asp Asp Leu Arg Ala Gly Ile Gln Gln Val Tyr 
            20                  25                  30          


Xaa Arg Gln Ser Met Ala Lys Ser Arg Tyr Met Glu Leu Tyr Xaa His 
        35                  40                  45              


Val Tyr Asn Tyr Cys Xaa Ser Val His Gln Phe Val Gly Leu Glu Leu 
    50                  55                  60                  


Tyr Lys Arg Leu Lys Glu Phe Leu Lys Asn Tyr Leu Xaa Asn Leu Leu 
65                  70                  75                  80  


Lys Asp Gly Glu Asp Leu Met Asp Glu Ser Val Leu Lys Phe Tyr Xaa 
                85                  90                  95      


Gln Gln Trp Glu Asp Tyr Arg Phe Ser Ser Lys Val Leu Asn Gly Ile 
            100                 105                 110         


Cys Ala Tyr Leu Asn Arg His Trp Val Arg Arg Glu Cys Asp Glu Gly 
        115                 120                 125             


Arg Lys Gly Ile Tyr Glu Ile Tyr Ser Leu Ala Leu Val Xaa Trp Arg 
    130                 135                 140                 


Asp Cys Leu Phe Arg Pro Leu Asn Lys Gln Val Xaa Asn Ala Val Leu 
145                 150                 155                 160 


Lys Leu Ile Glu Lys Glu Arg Asn Gly Glu Xaa Ile Asn Xaa Arg Leu 
                165                 170                 175     


Ile Ser Gly Val Val Gln Ser Tyr Val Glu Leu Gly Leu Asn Glu Asp 
            180                 185                 190         


Asp Ala Phe Ala Lys Gly Pro Xaa Leu Xaa Val Tyr Lys Glu Ser Phe 
        195                 200                 205             


Glu Ser Gln Phe Leu Ala Asp Xaa Glu Arg Phe Tyr Xaa Arg Glu Ser 
    210                 215                 220                 


Xaa Glu Phe Leu Gln Gln Asn Pro Val Xaa Glu Tyr Met Lys Lys Ala 
225                 230                 235                 240 


Glu Ala Arg Leu Leu Glu Glu Gln Arg Arg Val Gln Val Tyr Leu His 
                245                 250                 255     


Glu Ser Xaa Gln Asp Glu Leu Ala Arg Lys Cys Glu Gln Val Leu Ile 
            260                 265                 270         


Glu Lys His Leu Glu Ile Phe His Xaa Glu Phe Gln Asn Leu Leu Asp 
        275                 280                 285             


Ala Asp Lys Asn Glu Asp Leu Gly Arg Met Tyr Asn Leu Val Ser Arg 
    290                 295                 300                 


Ile Gln Asp Gly Leu Gly Glu Leu Lys Lys Leu Leu Glu Xaa His Ile 
305                 310                 315                 320 


His Asn Gln Gly Leu Ala Ala Ile Glu Lys Cys Gly Glu Ala Ala Leu 
                325                 330                 335     


Asn Asp Pro Lys Met Tyr Val Gln Xaa Val Leu Asp Val His Lys Lys 
            340                 345                 350         


Tyr Asn Ala Leu Val Met Ser Ala Phe Asn Asn Asp Ala Gly Phe Val 
        355                 360                 365             


Ala Ala Leu Asp Lys Ala Cys Gly Arg Phe Ile Asn Asn Asn Ala Val 
    370                 375                 380                 


Xaa Lys Met Ala Gln Ser Ser Ser Lys Ser Pro Glu Leu Leu Ala Arg 
385                 390                 395                 400 


Tyr Cys Asp Ser Leu Leu Lys Lys Ser Ser Lys Asn Pro Glu Glu Ala 
                405                 410                 415     


Glu Leu Glu Asp Xaa Leu Asn Gln Val Met Val Val Phe Lys Tyr Ile 
            420                 425                 430         


Glu Asp Lys Asp Val Phe Gln Lys Phe Tyr Ala Lys Met Leu Ala Lys 
        435                 440                 445             


Arg Leu Val His Gln Asn Ser Ala Ser Asp Asp Ala Glu Ala Ser Met 
    450                 455                 460                 


Ile Ser Lys Leu Lys Gln Ala Cys Gly Phe Glu Tyr Xaa Ser Lys Leu 
465                 470                 475                 480 


Gln Arg Met Phe Gln Asp Ile Gly Val Ser Lys Asp Leu Asn Glu Gln 
                485                 490                 495     


Phe Lys Lys His Leu Xaa Asn Ser Glu Pro Leu Asp Leu Asp Phe Ser 
            500                 505                 510         


Ile Gln Val Leu Ser Ser Gly Ser Trp Pro Phe Gln Gln Ser Cys Xaa 
        515                 520                 525             


Phe Ala Leu Pro Ser Glu Leu Glu Arg Ser Tyr Gln Arg Phe Xaa Ala 
    530                 535                 540                 


Phe Tyr Ala Ser Arg His Ser Gly Arg Lys Leu Xaa Trp Leu Tyr Gln 
545                 550                 555                 560 


Leu Ser Lys Gly Glu Leu Val Xaa Asn Cys Phe Lys Asn Arg Tyr Xaa 
                565                 570                 575     


Leu Gln Ala Ser Xaa Phe Gln Met Ala Ile Leu Leu Gln Tyr Asn Xaa 
            580                 585                 590         


Glu Asp Ala Tyr Xaa Val Gln Gln Leu Xaa Asp Ser Xaa Gln Ile Lys 
        595                 600                 605             


Met Asp Ile Leu Ala Gln Val Leu Gln Ile Leu Leu Lys Ser Lys Leu 
    610                 615                 620                 


Leu Val Leu Glu Asp Glu Asn Ala Asn Val Asp Glu Val Glu Leu Lys 
625                 630                 635                 640 


Pro Asp Xaa Leu Ile Lys Leu Tyr Leu Gly Tyr Lys Asn Lys Lys Leu 
                645                 650                 655     


Arg Val Asn Ile Asn Val Pro Met Lys Xaa Glu Gln Lys Gln Glu Gln 
            660                 665                 670         


Glu Xaa Xaa His Lys Asn Ile Glu Glu Asp Arg Lys Leu Leu Ile Gln 
        675                 680                 685             


Ala Ala Ile Val Arg Ile Met Lys Met Arg Lys Val Leu Lys His Gln 
    690                 695                 700                 


Gln Leu Leu Gly Glu Val Leu Xaa Gln Leu Ser Ser Arg Phe Lys Pro 
705                 710                 715                 720 


Arg Val Pro Val Ile Lys Lys Cys Ile Asp Ile Leu Ile Glu Lys Glu 
                725                 730                 735     


Tyr Leu Glu Arg Val Asp Gly Glu Lys Asp Xaa Tyr Ser Tyr Leu Ala 
            740                 745                 750         


<210> 7328
<211> 776
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (501)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<400> 7328
Met Ser Ser Xaa Arg Ser Gln Asn Pro His Gly Leu Lys Gln Ile Gly 
1               5                   10                  15      


Leu Asp Gln Ile Trp Asp Asp Leu Arg Ala Gly Ile Gln Gln Val Tyr 
            20                  25                  30          


Xaa Arg Gln Ser Met Ala Lys Ser Arg Tyr Met Glu Leu Tyr Xaa His 
        35                  40                  45              


Val Tyr Asn Tyr Cys Xaa Ser Val His Gln Ser Asn Gln Ala Arg Gly 
    50                  55                  60                  


Ala Gly Val Pro Pro Ser Lys Ser Lys Lys Gly Gln Xaa Pro Gly Gly 
65                  70                  75                  80  


Ala Gln Phe Val Gly Leu Glu Leu Tyr Lys Arg Leu Lys Glu Phe Leu 
                85                  90                  95      


Lys Asn Tyr Leu Xaa Asn Leu Leu Lys Asp Gly Glu Asp Leu Met Asp 
            100                 105                 110         


Glu Ser Val Leu Lys Phe Tyr Xaa Gln Gln Trp Glu Asp Tyr Arg Phe 
        115                 120                 125             


Ser Ser Lys Val Leu Asn Gly Ile Cys Ala Tyr Leu Asn Arg His Trp 
    130                 135                 140                 


Val Arg Arg Glu Cys Asp Glu Gly Arg Lys Gly Ile Tyr Glu Ile Tyr 
145                 150                 155                 160 


Ser Leu Ala Leu Val Xaa Trp Arg Asp Cys Leu Phe Arg Pro Leu Asn 
                165                 170                 175     


Lys Gln Val Xaa Asn Ala Val Leu Lys Leu Ile Glu Lys Glu Arg Asn 
            180                 185                 190         


Gly Glu Xaa Ile Asn Xaa Arg Leu Ile Ser Gly Val Val Gln Ser Tyr 
        195                 200                 205             


Val Glu Leu Gly Leu Asn Glu Asp Asp Ala Phe Ala Lys Gly Pro Xaa 
    210                 215                 220                 


Leu Xaa Val Tyr Lys Glu Ser Phe Glu Ser Gln Phe Leu Ala Asp Xaa 
225                 230                 235                 240 


Glu Arg Phe Tyr Xaa Arg Glu Ser Xaa Glu Phe Leu Gln Gln Asn Pro 
                245                 250                 255     


Val Xaa Glu Tyr Met Lys Lys Ala Glu Ala Arg Leu Leu Glu Glu Gln 
            260                 265                 270         


Arg Arg Val Gln Val Tyr Leu His Glu Ser Xaa Gln Asp Glu Leu Ala 
        275                 280                 285             


Arg Lys Cys Glu Gln Val Leu Ile Glu Lys His Leu Glu Ile Phe His 
    290                 295                 300                 


Xaa Glu Phe Gln Asn Leu Leu Asp Ala Asp Lys Asn Glu Asp Leu Gly 
305                 310                 315                 320 


Arg Met Tyr Asn Leu Val Ser Arg Ile Gln Asp Gly Leu Gly Glu Leu 
                325                 330                 335     


Lys Lys Leu Leu Glu Xaa His Ile His Asn Gln Gly Leu Ala Ala Ile 
            340                 345                 350         


Glu Lys Cys Gly Glu Ala Ala Leu Asn Asp Pro Lys Met Tyr Val Gln 
        355                 360                 365             


Xaa Val Leu Asp Val His Lys Lys Tyr Asn Ala Leu Val Met Ser Ala 
    370                 375                 380                 


Phe Asn Asn Asp Ala Gly Phe Val Ala Ala Leu Asp Lys Ala Cys Gly 
385                 390                 395                 400 


Arg Phe Ile Asn Asn Asn Ala Val Xaa Lys Met Ala Gln Ser Ser Ser 
                405                 410                 415     


Lys Ser Pro Glu Leu Leu Ala Arg Tyr Cys Asp Ser Leu Leu Lys Lys 
            420                 425                 430         


Ser Ser Lys Asn Pro Glu Glu Ala Glu Leu Glu Asp Xaa Leu Asn Gln 
        435                 440                 445             


Val Met Val Val Phe Lys Tyr Ile Glu Asp Lys Asp Val Phe Gln Lys 
    450                 455                 460                 


Phe Tyr Ala Lys Met Leu Ala Lys Arg Leu Val His Gln Asn Ser Ala 
465                 470                 475                 480 


Ser Asp Asp Ala Glu Ala Ser Met Ile Ser Lys Leu Lys Gln Ala Cys 
                485                 490                 495     


Gly Phe Glu Tyr Xaa Ser Lys Leu Gln Arg Met Phe Gln Asp Ile Gly 
            500                 505                 510         


Val Ser Lys Asp Leu Asn Glu Gln Phe Lys Lys His Leu Xaa Asn Ser 
        515                 520                 525             


Glu Pro Leu Asp Leu Asp Phe Ser Ile Gln Val Leu Ser Ser Gly Ser 
    530                 535                 540                 


Trp Pro Phe Gln Gln Ser Cys Xaa Phe Ala Leu Pro Ser Glu Leu Glu 
545                 550                 555                 560 


Arg Ser Tyr Gln Arg Phe Xaa Ala Phe Tyr Ala Ser Arg His Ser Gly 
                565                 570                 575     


Arg Lys Leu Xaa Trp Leu Tyr Gln Leu Ser Lys Gly Glu Leu Val Xaa 
            580                 585                 590         


Asn Cys Phe Lys Asn Arg Tyr Xaa Leu Gln Ala Ser Xaa Phe Gln Met 
        595                 600                 605             


Ala Ile Leu Leu Gln Tyr Asn Xaa Glu Asp Ala Tyr Xaa Val Gln Gln 
    610                 615                 620                 


Leu Xaa Asp Ser Xaa Gln Ile Lys Met Asp Ile Leu Ala Gln Val Leu 
625                 630                 635                 640 


Gln Ile Leu Leu Lys Ser Lys Leu Leu Val Leu Glu Asp Glu Asn Ala 
                645                 650                 655     


Asn Val Asp Glu Val Glu Leu Lys Pro Asp Xaa Leu Ile Lys Leu Tyr 
            660                 665                 670         


Leu Gly Tyr Lys Asn Lys Lys Leu Arg Val Asn Ile Asn Val Pro Met 
        675                 680                 685             


Lys Xaa Glu Gln Lys Gln Glu Gln Glu Xaa Xaa His Lys Asn Ile Glu 
    690                 695                 700                 


Glu Asp Arg Lys Leu Leu Ile Gln Ala Ala Ile Val Arg Ile Met Lys 
705                 710                 715                 720 


Met Arg Lys Val Leu Lys His Gln Gln Leu Leu Gly Glu Val Leu Xaa 
                725                 730                 735     


Gln Leu Ser Ser Arg Phe Lys Pro Arg Val Pro Val Ile Lys Lys Cys 
            740                 745                 750         


Ile Asp Ile Leu Ile Glu Lys Glu Tyr Leu Glu Arg Val Asp Gly Glu 
        755                 760                 765             


Lys Asp Xaa Tyr Ser Tyr Leu Ala 
    770                 775     


<210> 7329
<211> 706
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<400> 7329
Met Ser Leu Lys Pro Arg Val Val Asp Phe Asp Glu Xaa Trp Asn Lys 
1               5                   10                  15      


Leu Leu Xaa Xaa Ile Lys Ala Val Val Met Leu Glu Tyr Val Glu Arg 
            20                  25                  30          


Ala Xaa Trp Asn Asp Arg Phe Ser Asp Ile Tyr Ala Leu Cys Val Ala 
        35                  40                  45              


Tyr Pro Glu Pro Leu Gly Glu Arg Leu Tyr Xaa Glu Xaa Lys Ile Phe 
    50                  55                  60                  


Leu Glu Asn His Val Arg His Leu His Lys Arg Val Leu Glu Ser Glu 
65                  70                  75                  80  


Glu Gln Val Leu Val Met Tyr His Arg Tyr Trp Glu Glu Tyr Ser Lys 
                85                  90                  95      


Gly Ala Asp Tyr Met Asp Cys Leu Tyr Arg Tyr Leu Asn Xaa Gln Phe 
            100                 105                 110         


Ile Lys Lys Asn Lys Leu Xaa Glu Ala Asp Leu Gln Tyr Gly Tyr Gly 
        115                 120                 125             


Gly Val Asp Met Asn Glu Pro Leu Met Glu Ile Gly Glu Leu Ala Leu 
    130                 135                 140                 


Asp Met Trp Arg Lys Leu Met Val Glu Pro Leu Gln Ala Ile Leu Ile 
145                 150                 155                 160 


Arg Met Leu Leu Arg Glu Ile Lys Asn Asp Arg Gly Gly Glu Asp Pro 
                165                 170                 175     


Asn Gln Lys Val Ile His Gly Val Ile Asn Ser Phe Val His Val Glu 
            180                 185                 190         


Gln Tyr Lys Lys Lys Phe Pro Leu Lys Phe Tyr Gln Glu Ile Phe Glu 
        195                 200                 205             


Ser Pro Phe Leu Xaa Glu Xaa Gly Glu Tyr Tyr Lys Gln Glu Ala Ser 
    210                 215                 220                 


Asn Leu Leu Gln Glu Ser Asn Cys Ser Gln Tyr Met Glu Lys Val Leu 
225                 230                 235                 240 


Gly Arg Leu Lys Asp Glu Glu Ile Arg Cys Arg Lys Tyr Leu His Pro 
                245                 250                 255     


Ser Ser Tyr Xaa Lys Val Ile His Glu Cys Gln Gln Arg Met Val Ala 
            260                 265                 270         


Asp His Leu Gln Phe Leu His Ala Glu Cys His Asn Ile Ile Arg Gln 
        275                 280                 285             


Glu Lys Lys Asn Asp Met Ala Asn Met Tyr Val Leu Leu Arg Ala Val 
    290                 295                 300                 


Ser Xaa Gly Leu Pro His Met Ile Gln Glu Leu Gln Asn His Ile His 
305                 310                 315                 320 


Asp Glu Gly Leu Arg Ala Xaa Ser Asn Leu Xaa Gln Glu Asn Met Pro 
                325                 330                 335     


Xaa Leu Phe Val Glu Ser Val Leu Glu Val His Gly Lys Phe Val Gln 
            340                 345                 350         


Leu Ile Asn Xaa Val Leu Asn Gly Asp Gln His Phe Met Ser Ala Leu 
        355                 360                 365             


Asp Lys Ala Leu Xaa Ser Val Val Asn Tyr Arg Glu Pro Lys Ser Val 
    370                 375                 380                 


Cys Lys Ala Pro Glu Leu Leu Ala Lys Tyr Cys Asp Asn Leu Leu Lys 
385                 390                 395                 400 


Lys Ser Ala Lys Gly Met Xaa Glu Asn Glu Val Glu Asp Arg Leu Xaa 
                405                 410                 415     


Ser Phe Ile Xaa Val Phe Lys Tyr Ile Asp Asp Lys Asp Val Phe Gln 
            420                 425                 430         


Lys Phe Tyr Ala Arg Met Leu Ala Lys Arg Leu Ile His Gly Leu Ser 
        435                 440                 445             


Met Ser Met Asp Ser Glu Glu Ala Met Ile Asn Lys Leu Lys Gln Ala 
    450                 455                 460                 


Cys Gly Tyr Glu Phe Xaa Ser Lys Leu His Arg Met Tyr Xaa Asp Met 
465                 470                 475                 480 


Ser Val Ser Ala Asp Leu Asn Asn Lys Phe Asn Asn Phe Ile Lys Asn 
                485                 490                 495     


Gln Asp Xaa Val Ile Asp Leu Gly Ile Ser Phe Gln Ile Tyr Val Leu 
            500                 505                 510         


Gln Ala Gly Ala Trp Pro Leu Xaa Gln Ala Pro Ser Ser Xaa Phe Ala 
        515                 520                 525             


Ile Pro Gln Glu Leu Glu Lys Ser Val Gln Met Phe Glu Leu Phe Tyr 
    530                 535                 540                 


Ser Gln His Phe Ser Gly Arg Lys Leu Xaa Trp Leu His Tyr Leu Cys 
545                 550                 555                 560 


Xaa Gly Glu Val Lys Met Asn Tyr Leu Gly Lys Pro Tyr Val Ala Met 
                565                 570                 575     


Val Xaa Xaa Tyr Gln Met Ala Val Leu Leu Ala Phe Asn Asn Ser Glu 
            580                 585                 590         


Xaa Val Ser Tyr Lys Glu Leu Gln Asp Ser Xaa Gln Met Asn Glu Lys 
        595                 600                 605             


Glu Leu Xaa Lys Xaa Ile Lys Ser Leu Leu Asp Val Lys Met Ile Asn 
    610                 615                 620                 


His Asp Ser Glu Lys Glu Asp Ile Asp Ala Glu Ser Ser Phe Ser Leu 
625                 630                 635                 640 


Asn Met Asn Phe Ser Ser Lys Arg Xaa Lys Phe Lys Ile Xaa Xaa Ser 
                645                 650                 655     


Met Gln Lys Asp Xaa Pro Gln Val Ile Ser Gln Ser Arg Ala Arg Phe 
            660                 665                 670         


Asn Pro Ser Ile Ser Met Ile Lys Lys Cys Ile Glu Val Leu Ile Asp 
        675                 680                 685             


Lys Gln Tyr Ile Glu Arg Ser Gln Ala Ser Ala Asp Glu Tyr Ser Tyr 
    690                 695                 700                 


Val Ala 
705     


<210> 7330
<211> 745
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (499)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (561)..(561)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<400> 7330
Met Ser Leu Lys Pro Arg Val Val Asp Phe Asp Glu Xaa Trp Asn Lys 
1               5                   10                  15      


Leu Leu Xaa Xaa Ile Lys Ala Val Val Met Leu Glu Tyr Val Glu Arg 
            20                  25                  30          


Ala Xaa Trp Asn Asp Arg Phe Ser Asp Ile Tyr Ala Leu Cys Val Ala 
        35                  40                  45              


Tyr Pro Glu Pro Leu Gly Glu Arg Leu Tyr Xaa Glu Xaa Lys Ile Phe 
    50                  55                  60                  


Leu Glu Asn His Val Arg His Leu His Lys Arg Val Leu Glu Ser Glu 
65                  70                  75                  80  


Glu Gln Val Leu Val Met Tyr His Arg Tyr Trp Glu Glu Tyr Ser Lys 
                85                  90                  95      


Gly Ala Asp Tyr Met Asp Cys Leu Tyr Arg Tyr Leu Asn Xaa Gln Phe 
            100                 105                 110         


Ile Lys Lys Asn Lys Leu Xaa Glu Ala Asp Leu Gln Tyr Gly Tyr Gly 
        115                 120                 125             


Gly Val Asp Met Asn Glu Pro Leu Met Glu Ile Gly Glu Leu Ala Leu 
    130                 135                 140                 


Asp Met Trp Arg Lys Leu Met Val Glu Pro Leu Gln Ala Ile Leu Ile 
145                 150                 155                 160 


Arg Met Leu Leu Arg Glu Ile Lys Asn Asp Arg Gly Gly Glu Asp Pro 
                165                 170                 175     


Asn Gln Lys Val Ile His Gly Val Ile Asn Ser Phe Val His Val Glu 
            180                 185                 190         


Gln Tyr Lys Lys Lys Phe Pro Leu Lys Phe Tyr Gln Glu Ile Phe Glu 
        195                 200                 205             


Ser Pro Phe Leu Xaa Glu Xaa Gly Glu Tyr Tyr Lys Gln Glu Ala Ser 
    210                 215                 220                 


Asn Leu Leu Gln Glu Ser Asn Cys Ser Gln Tyr Met Glu Lys Val Leu 
225                 230                 235                 240 


Gly Arg Leu Lys Asp Glu Glu Ile Arg Cys Arg Lys Tyr Leu His Pro 
                245                 250                 255     


Ser Ser Tyr Xaa Lys Val Ile His Glu Cys Gln Gln Arg Met Val Ala 
            260                 265                 270         


Asp His Leu Gln Phe Leu His Ala Glu Cys His Asn Ile Ile Arg Gln 
        275                 280                 285             


Glu Lys Lys Asn Asp Met Ala Asn Met Tyr Val Leu Leu Arg Ala Val 
    290                 295                 300                 


Ser Xaa Gly Leu Pro His Met Ile Gln Glu Leu Gln Asn His Ile His 
305                 310                 315                 320 


Asp Glu Gly Leu Arg Ala Xaa Ser Asn Leu Xaa Gln Glu Asn Met Pro 
                325                 330                 335     


Xaa Leu Phe Val Glu Ser Val Leu Glu Val His Gly Lys Phe Val Gln 
            340                 345                 350         


Leu Ile Asn Xaa Val Leu Asn Gly Asp Gln His Phe Met Ser Ala Leu 
        355                 360                 365             


Asp Lys Ala Leu Xaa Ser Val Val Asn Tyr Arg Glu Pro Lys Ser Val 
    370                 375                 380                 


Cys Lys Ala Pro Glu Leu Leu Ala Lys Tyr Cys Asp Asn Leu Leu Lys 
385                 390                 395                 400 


Lys Ser Ala Lys Gly Met Xaa Glu Asn Glu Val Glu Asp Arg Leu Xaa 
                405                 410                 415     


Ser Phe Ile Xaa Val Phe Lys Tyr Ile Asp Asp Lys Asp Val Phe Gln 
            420                 425                 430         


Lys Phe Tyr Ala Arg Met Leu Ala Lys Arg Leu Ile His Gly Leu Ser 
        435                 440                 445             


Met Ser Met Asp Ser Glu Glu Ala Met Ile Asn Lys Leu Lys Gln Ala 
    450                 455                 460                 


Cys Gly Tyr Glu Phe Xaa Ser Lys Leu His Arg Met Tyr Xaa Asp Met 
465                 470                 475                 480 


Ser Val Ser Ala Asp Leu Asn Asn Lys Phe Asn Asn Phe Ile Lys Asn 
                485                 490                 495     


Gln Asp Xaa Val Ile Asp Leu Gly Ile Ser Phe Gln Ile Tyr Val Leu 
            500                 505                 510         


Gln Ala Gly Ala Trp Pro Leu Xaa Gln Ala Pro Ser Ser Xaa Phe Ala 
        515                 520                 525             


Ile Pro Gln Glu Leu Glu Lys Ser Val Gln Met Phe Glu Leu Phe Tyr 
    530                 535                 540                 


Ser Gln His Phe Ser Gly Arg Lys Leu Xaa Trp Leu His Tyr Leu Cys 
545                 550                 555                 560 


Xaa Gly Glu Val Lys Met Asn Tyr Leu Gly Lys Pro Tyr Val Ala Met 
                565                 570                 575     


Val Xaa Xaa Tyr Gln Met Ala Val Leu Leu Ala Phe Asn Asn Ser Glu 
            580                 585                 590         


Xaa Val Ser Tyr Lys Glu Leu Gln Asp Ser Xaa Gln Met Asn Glu Lys 
        595                 600                 605             


Glu Leu Xaa Lys Xaa Ile Lys Ser Leu Leu Asp Val Lys Met Ile Asn 
    610                 615                 620                 


His Asp Ser Glu Lys Glu Asp Ile Asp Ala Glu Ser Ser Phe Ser Leu 
625                 630                 635                 640 


Asn Met Asn Phe Ser Ser Lys Arg Xaa Lys Phe Lys Ile Xaa Xaa Ser 
                645                 650                 655     


Met Gln Lys Asp Xaa Pro Gln Glu Met Glu Gln Xaa Arg Ser Ala Val 
            660                 665                 670         


Asp Glu Asp Arg Lys Met Tyr Leu Gln Ala Ala Ile Val Arg Ile Met 
        675                 680                 685             


Lys Ala Arg Lys Val Leu Arg His Asn Ala Leu Ile Gln Glu Val Ile 
    690                 695                 700                 


Ser Gln Ser Arg Ala Arg Phe Asn Pro Ser Ile Ser Met Ile Lys Lys 
705                 710                 715                 720 


Cys Ile Glu Val Leu Ile Asp Lys Gln Tyr Ile Glu Arg Ser Gln Ala 
                725                 730                 735     


Ser Ala Asp Glu Tyr Ser Tyr Val Ala 
            740                 745 


<210> 7331
<211> 90
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Selenocysteine

<400> 7331
Met Ser Leu Lys Pro Arg Val Val Asp Phe Asp Glu Xaa Trp Asn Lys 
1               5                   10                  15      


Leu Leu Xaa Xaa Ile Lys Ala Val Val Met Leu Glu Tyr Val Glu Arg 
            20                  25                  30          


Ala Xaa Trp Asn Asp Arg Phe Ser Asp Ile Tyr Ala Leu Cys Val Ala 
        35                  40                  45              


Tyr Pro Glu Pro Leu Gly Glu Arg Leu Tyr Xaa Glu Xaa Lys Ile Phe 
    50                  55                  60                  


Leu Glu Asn His Val Arg His Leu His Lys Val Leu Gly Arg Ile Gln 
65                  70                  75                  80  


Gln Gly Cys Arg Leu Tyr Gly Leu Leu Ile 
                85                  90  


<210> 7332
<211> 758
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (591)..(592)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (624)..(624)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<400> 7332
Met Val Pro Gly Lys Glu Phe Gln His Tyr Xaa Cys Xaa Met Ser Leu 
1               5                   10                  15      


Lys Pro Arg Val Val Asp Phe Asp Glu Xaa Trp Asn Lys Leu Leu Xaa 
            20                  25                  30          


Xaa Ile Lys Ala Val Val Met Leu Glu Tyr Val Glu Arg Ala Xaa Trp 
        35                  40                  45              


Asn Asp Arg Phe Ser Asp Ile Tyr Ala Leu Cys Val Ala Tyr Pro Glu 
    50                  55                  60                  


Pro Leu Gly Glu Arg Leu Tyr Xaa Glu Xaa Lys Ile Phe Leu Glu Asn 
65                  70                  75                  80  


His Val Arg His Leu His Lys Arg Val Leu Glu Ser Glu Glu Gln Val 
                85                  90                  95      


Leu Val Met Tyr His Arg Tyr Trp Glu Glu Tyr Ser Lys Gly Ala Asp 
            100                 105                 110         


Tyr Met Asp Cys Leu Tyr Arg Tyr Leu Asn Xaa Gln Phe Ile Lys Lys 
        115                 120                 125             


Asn Lys Leu Xaa Glu Ala Asp Leu Gln Tyr Gly Tyr Gly Gly Val Asp 
    130                 135                 140                 


Met Asn Glu Pro Leu Met Glu Ile Gly Glu Leu Ala Leu Asp Met Trp 
145                 150                 155                 160 


Arg Lys Leu Met Val Glu Pro Leu Gln Ala Ile Leu Ile Arg Met Leu 
                165                 170                 175     


Leu Arg Glu Ile Lys Asn Asp Arg Gly Gly Glu Asp Pro Asn Gln Lys 
            180                 185                 190         


Val Ile His Gly Val Ile Asn Ser Phe Val His Val Glu Gln Tyr Lys 
        195                 200                 205             


Lys Lys Phe Pro Leu Lys Phe Tyr Gln Glu Ile Phe Glu Ser Pro Phe 
    210                 215                 220                 


Leu Xaa Glu Xaa Gly Glu Tyr Tyr Lys Gln Glu Ala Ser Asn Leu Leu 
225                 230                 235                 240 


Gln Glu Ser Asn Cys Ser Gln Tyr Met Glu Lys Val Leu Gly Arg Leu 
                245                 250                 255     


Lys Asp Glu Glu Ile Arg Cys Arg Lys Tyr Leu His Pro Ser Ser Tyr 
            260                 265                 270         


Xaa Lys Val Ile His Glu Cys Gln Gln Arg Met Val Ala Asp His Leu 
        275                 280                 285             


Gln Phe Leu His Ala Glu Cys His Asn Ile Ile Arg Gln Glu Lys Lys 
    290                 295                 300                 


Asn Asp Met Ala Asn Met Tyr Val Leu Leu Arg Ala Val Ser Xaa Gly 
305                 310                 315                 320 


Leu Pro His Met Ile Gln Glu Leu Gln Asn His Ile His Asp Glu Gly 
                325                 330                 335     


Leu Arg Ala Xaa Ser Asn Leu Xaa Gln Glu Asn Met Pro Xaa Leu Phe 
            340                 345                 350         


Val Glu Ser Val Leu Glu Val His Gly Lys Phe Val Gln Leu Ile Asn 
        355                 360                 365             


Xaa Val Leu Asn Gly Asp Gln His Phe Met Ser Ala Leu Asp Lys Ala 
    370                 375                 380                 


Leu Xaa Ser Val Val Asn Tyr Arg Glu Pro Lys Ser Val Cys Lys Ala 
385                 390                 395                 400 


Pro Glu Leu Leu Ala Lys Tyr Cys Asp Asn Leu Leu Lys Lys Ser Ala 
                405                 410                 415     


Lys Gly Met Xaa Glu Asn Glu Val Glu Asp Arg Leu Xaa Ser Phe Ile 
            420                 425                 430         


Xaa Val Phe Lys Tyr Ile Asp Asp Lys Asp Val Phe Gln Lys Phe Tyr 
        435                 440                 445             


Ala Arg Met Leu Ala Lys Arg Leu Ile His Gly Leu Ser Met Ser Met 
    450                 455                 460                 


Asp Ser Glu Glu Ala Met Ile Asn Lys Leu Lys Gln Ala Cys Gly Tyr 
465                 470                 475                 480 


Glu Phe Xaa Ser Lys Leu His Arg Met Tyr Xaa Asp Met Ser Val Ser 
                485                 490                 495     


Ala Asp Leu Asn Asn Lys Phe Asn Asn Phe Ile Lys Asn Gln Asp Xaa 
            500                 505                 510         


Val Ile Asp Leu Gly Ile Ser Phe Gln Ile Tyr Val Leu Gln Ala Gly 
        515                 520                 525             


Ala Trp Pro Leu Xaa Gln Ala Pro Ser Ser Xaa Phe Ala Ile Pro Gln 
    530                 535                 540                 


Glu Leu Glu Lys Ser Val Gln Met Phe Glu Leu Phe Tyr Ser Gln His 
545                 550                 555                 560 


Phe Ser Gly Arg Lys Leu Xaa Trp Leu His Tyr Leu Cys Xaa Gly Glu 
                565                 570                 575     


Val Lys Met Asn Tyr Leu Gly Lys Pro Tyr Val Ala Met Val Xaa Xaa 
            580                 585                 590         


Tyr Gln Met Ala Val Leu Leu Ala Phe Asn Asn Ser Glu Xaa Val Ser 
        595                 600                 605             


Tyr Lys Glu Leu Gln Asp Ser Xaa Gln Met Asn Glu Lys Glu Leu Xaa 
    610                 615                 620                 


Lys Xaa Ile Lys Ser Leu Leu Asp Val Lys Met Ile Asn His Asp Ser 
625                 630                 635                 640 


Glu Lys Glu Asp Ile Asp Ala Glu Ser Ser Phe Ser Leu Asn Met Asn 
                645                 650                 655     


Phe Ser Ser Lys Arg Xaa Lys Phe Lys Ile Xaa Xaa Ser Met Gln Lys 
            660                 665                 670         


Asp Xaa Pro Gln Glu Met Glu Gln Xaa Arg Ser Ala Val Asp Glu Asp 
        675                 680                 685             


Arg Lys Met Tyr Leu Gln Ala Ala Ile Val Arg Ile Met Lys Ala Arg 
    690                 695                 700                 


Lys Val Leu Arg His Asn Ala Leu Ile Gln Glu Val Ile Ser Gln Ser 
705                 710                 715                 720 


Arg Ala Arg Phe Asn Pro Ser Ile Ser Met Ile Lys Lys Cys Ile Glu 
                725                 730                 735     


Val Leu Ile Asp Lys Gln Tyr Ile Glu Arg Ser Gln Ala Ser Ala Asp 
            740                 745                 750         


Glu Tyr Ser Tyr Val Ala 
        755             


<210> 7333
<211> 764
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (497)..(497)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(668)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<400> 7333
Met Tyr Arg Val Xaa Trp Ser Xaa Phe Trp Leu Arg Phe Gln His Tyr 
1               5                   10                  15      


Xaa Cys Xaa Met Ser Leu Lys Pro Arg Val Val Asp Phe Asp Glu Xaa 
            20                  25                  30          


Trp Asn Lys Leu Leu Xaa Xaa Ile Lys Ala Val Val Met Leu Glu Tyr 
        35                  40                  45              


Val Glu Arg Ala Xaa Trp Asn Asp Arg Phe Ser Asp Ile Tyr Ala Leu 
    50                  55                  60                  


Cys Val Ala Tyr Pro Glu Pro Leu Gly Glu Arg Leu Tyr Xaa Glu Xaa 
65                  70                  75                  80  


Lys Ile Phe Leu Glu Asn His Val Arg His Leu His Lys Arg Val Leu 
                85                  90                  95      


Glu Ser Glu Glu Gln Val Leu Val Met Tyr His Arg Tyr Trp Glu Glu 
            100                 105                 110         


Tyr Ser Lys Gly Ala Asp Tyr Met Asp Cys Leu Tyr Arg Tyr Leu Asn 
        115                 120                 125             


Xaa Gln Phe Ile Lys Lys Asn Lys Leu Xaa Glu Ala Asp Leu Gln Tyr 
    130                 135                 140                 


Gly Tyr Gly Gly Val Asp Met Asn Glu Pro Leu Met Glu Ile Gly Glu 
145                 150                 155                 160 


Leu Ala Leu Asp Met Trp Arg Lys Leu Met Val Glu Pro Leu Gln Ala 
                165                 170                 175     


Ile Leu Ile Arg Met Leu Leu Arg Glu Ile Lys Asn Asp Arg Gly Gly 
            180                 185                 190         


Glu Asp Pro Asn Gln Lys Val Ile His Gly Val Ile Asn Ser Phe Val 
        195                 200                 205             


His Val Glu Gln Tyr Lys Lys Lys Phe Pro Leu Lys Phe Tyr Gln Glu 
    210                 215                 220                 


Ile Phe Glu Ser Pro Phe Leu Xaa Glu Xaa Gly Glu Tyr Tyr Lys Gln 
225                 230                 235                 240 


Glu Ala Ser Asn Leu Leu Gln Glu Ser Asn Cys Ser Gln Tyr Met Glu 
                245                 250                 255     


Lys Val Leu Gly Arg Leu Lys Asp Glu Glu Ile Arg Cys Arg Lys Tyr 
            260                 265                 270         


Leu His Pro Ser Ser Tyr Xaa Lys Val Ile His Glu Cys Gln Gln Arg 
        275                 280                 285             


Met Val Ala Asp His Leu Gln Phe Leu His Ala Glu Cys His Asn Ile 
    290                 295                 300                 


Ile Arg Gln Glu Lys Lys Asn Asp Met Ala Asn Met Tyr Val Leu Leu 
305                 310                 315                 320 


Arg Ala Val Ser Xaa Gly Leu Pro His Met Ile Gln Glu Leu Gln Asn 
                325                 330                 335     


His Ile His Asp Glu Gly Leu Arg Ala Xaa Ser Asn Leu Xaa Gln Glu 
            340                 345                 350         


Asn Met Pro Xaa Leu Phe Val Glu Ser Val Leu Glu Val His Gly Lys 
        355                 360                 365             


Phe Val Gln Leu Ile Asn Xaa Val Leu Asn Gly Asp Gln His Phe Met 
    370                 375                 380                 


Ser Ala Leu Asp Lys Ala Leu Xaa Ser Val Val Asn Tyr Arg Glu Pro 
385                 390                 395                 400 


Lys Ser Val Cys Lys Ala Pro Glu Leu Leu Ala Lys Tyr Cys Asp Asn 
                405                 410                 415     


Leu Leu Lys Lys Ser Ala Lys Gly Met Xaa Glu Asn Glu Val Glu Asp 
            420                 425                 430         


Arg Leu Xaa Ser Phe Ile Xaa Val Phe Lys Tyr Ile Asp Asp Lys Asp 
        435                 440                 445             


Val Phe Gln Lys Phe Tyr Ala Arg Met Leu Ala Lys Arg Leu Ile His 
    450                 455                 460                 


Gly Leu Ser Met Ser Met Asp Ser Glu Glu Ala Met Ile Asn Lys Leu 
465                 470                 475                 480 


Lys Gln Ala Cys Gly Tyr Glu Phe Xaa Ser Lys Leu His Arg Met Tyr 
                485                 490                 495     


Xaa Asp Met Ser Val Ser Ala Asp Leu Asn Asn Lys Phe Asn Asn Phe 
            500                 505                 510         


Ile Lys Asn Gln Asp Xaa Val Ile Asp Leu Gly Ile Ser Phe Gln Ile 
        515                 520                 525             


Tyr Val Leu Gln Ala Gly Ala Trp Pro Leu Xaa Gln Ala Pro Ser Ser 
    530                 535                 540                 


Xaa Phe Ala Ile Pro Gln Glu Leu Glu Lys Ser Val Gln Met Phe Glu 
545                 550                 555                 560 


Leu Phe Tyr Ser Gln His Phe Ser Gly Arg Lys Leu Xaa Trp Leu His 
                565                 570                 575     


Tyr Leu Cys Xaa Gly Glu Val Lys Met Asn Tyr Leu Gly Lys Pro Tyr 
            580                 585                 590         


Val Ala Met Val Xaa Xaa Tyr Gln Met Ala Val Leu Leu Ala Phe Asn 
        595                 600                 605             


Asn Ser Glu Xaa Val Ser Tyr Lys Glu Leu Gln Asp Ser Xaa Gln Met 
    610                 615                 620                 


Asn Glu Lys Glu Leu Xaa Lys Xaa Ile Lys Ser Leu Leu Asp Val Lys 
625                 630                 635                 640 


Met Ile Asn His Asp Ser Glu Lys Glu Asp Ile Asp Ala Glu Ser Ser 
                645                 650                 655     


Phe Ser Leu Asn Met Asn Phe Ser Ser Lys Arg Xaa Lys Phe Lys Ile 
            660                 665                 670         


Xaa Xaa Ser Met Gln Lys Asp Xaa Pro Gln Glu Met Glu Gln Xaa Arg 
        675                 680                 685             


Ser Ala Val Asp Glu Asp Arg Lys Met Tyr Leu Gln Ala Ala Ile Val 
    690                 695                 700                 


Arg Ile Met Lys Ala Arg Lys Val Leu Arg His Asn Ala Leu Ile Gln 
705                 710                 715                 720 


Glu Val Ile Ser Gln Ser Arg Ala Arg Phe Asn Pro Ser Ile Ser Met 
                725                 730                 735     


Ile Lys Lys Cys Ile Glu Val Leu Ile Asp Lys Gln Tyr Ile Glu Arg 
            740                 745                 750         


Ser Gln Ala Ser Ala Asp Glu Tyr Ser Tyr Val Ala 
        755                 760                 


<210> 7334
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<400> 7334
Asp Leu Leu Lys Asn Ala Ile Gln Glu Ile Gln Arg Lys Asn Asn Ser 
1               5                   10                  15      


Gly Leu Ser Phe Glu Glu Leu Tyr Arg Asn Ala Tyr Xaa Met Val Leu 
            20                  25                  30          


His Lys His Gly Glu Lys Leu Tyr Xaa Gly Leu Arg Glu Val Val Xaa 
        35                  40                  45              


Glu His Leu Ile Asn Lys Glu 
    50                  55  


<210> 7335
<211> 43
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<400> 7335
His Ile Leu Gln Val Ser Xaa Phe Gln Met Xaa Ile Leu Met Leu Phe 
1               5                   10                  15      


Asn Asn Arg Glu Lys Tyr Xaa Phe Glu Leu Leu Pro Asn Lys Val Asn 
            20                  25                  30          


Pro Xaa Gln Arg Gly Lys Lys Gln Gly Arg Lys 
        35                  40              


<210> 7336
<211> 744
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (559)..(559)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (733)..(733)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<400> 7336
Met Asp Glu Lys Tyr Val Asn Ser Ile Trp Asp Leu Leu Lys Asn Ala 
1               5                   10                  15      


Ile Gln Glu Ile Gln Arg Lys Asn Asn Ser Gly Leu Ser Phe Glu Glu 
            20                  25                  30          


Leu Tyr Arg Asn Ala Tyr Xaa Met Val Leu His Lys His Gly Glu Lys 
        35                  40                  45              


Leu Tyr Xaa Gly Leu Arg Glu Val Val Xaa Glu His Leu Ile Asn Lys 
    50                  55                  60                  


Val Arg Glu Asp Val Leu Asn Ser Leu Asn Asn Asn Phe Leu Gln Xaa 
65                  70                  75                  80  


Leu Asn Gln Ala Trp Asn Asp His Gln Xaa Ala Met Val Met Ile Arg 
                85                  90                  95      


Asp Ile Leu Met Tyr Met Asp Arg Val Tyr Val Gln Gln Asn Asn Val 
            100                 105                 110         


Glu Asn Val Tyr Asn Leu Gly Leu Ile Ile Phe Arg Asp Gln Val Val 
        115                 120                 125             


Arg Tyr Gly Cys Ile Arg Asp His Leu Arg Gln Xaa Leu Leu Asp Met 
    130                 135                 140                 


Ile Ala Arg Glu Arg Lys Gly Glu Val Val Asp Arg Gly Ala Ile Arg 
145                 150                 155                 160 


Asn Ala Cys Gln Met Leu Met Ile Leu Gly Leu Glu Gly Arg Ser Val 
                165                 170                 175     


Tyr Glu Glu Asp Phe Glu Ala Pro Phe Leu Glu Met Ser Ala Glu Phe 
            180                 185                 190         


Phe Gln Met Glu Ser Gln Lys Phe Leu Ala Glu Asn Ser Ala Ser Val 
        195                 200                 205             


Tyr Ile Lys Lys Val Glu Ala Arg Ile Asn Glu Glu Ile Glu Arg Val 
    210                 215                 220                 


Met His Cys Leu Asp Lys Ser Xaa Glu Glu Pro Ile Val Lys Val Val 
225                 230                 235                 240 


Glu Arg Glu Leu Ile Ser Lys His Met Lys Xaa Ile Val Glu Met Glu 
                245                 250                 255     


Asn Ser Gly Leu Val His Met Leu Lys Asn Gly Lys Xaa Glu Asp Leu 
            260                 265                 270         


Gly Cys Met Tyr Lys Leu Phe Ser Arg Val Pro Asn Gly Leu Lys Xaa 
        275                 280                 285             


Met Cys Glu Cys Met Ser Ser Tyr Leu Arg Glu Gln Gly Lys Ala Leu 
    290                 295                 300                 


Val Ser Glu Glu Gly Glu Gly Lys Asn Pro Val Asp Tyr Ile Gln Gly 
305                 310                 315                 320 


Leu Leu Asp Leu Lys Ser Arg Phe Asp Arg Phe Leu Leu Glu Ser Phe 
                325                 330                 335     


Asn Asn Asp Arg Leu Phe Lys Gln Xaa Ile Ala Gly Asp Phe Glu Tyr 
            340                 345                 350         


Phe Leu Asn Leu Asn Ser Arg Ser Pro Glu Tyr Leu Ser Leu Phe Ile 
        355                 360                 365             


Asp Asp Lys Leu Lys Lys Gly Val Lys Gly Leu Xaa Glu Gln Glu Val 
    370                 375                 380                 


Glu Xaa Ile Leu Asp Lys Ala Met Val Leu Phe Arg Phe Met Gln Glu 
385                 390                 395                 400 


Lys Asp Val Phe Glu Arg Tyr Tyr Lys Gln His Leu Ala Arg Arg Leu 
                405                 410                 415     


Leu Xaa Asn Lys Ser Val Ser Asp Asp Ser Glu Lys Asn Met Ile Ser 
            420                 425                 430         


Lys Leu Lys Xaa Glu Cys Gly Cys Gln Phe Xaa Ser Lys Leu Glu Gly 
        435                 440                 445             


Met Phe Arg Asp Met Ser Ile Ser Asn Xaa Xaa Met Asp Glu Phe Arg 
    450                 455                 460                 


Gln His Leu Gln Ala Xaa Gly Val Ser Leu Gly Gly Val Asp Leu Xaa 
465                 470                 475                 480 


Val Arg Val Leu Xaa Xaa Gly Tyr Trp Pro Xaa Gln Ser Ala Xaa Pro 
                485                 490                 495     


Lys Cys Asn Ile Pro Pro Ala Pro Arg His Ala Phe Glu Ile Phe Arg 
            500                 505                 510         


Arg Phe Tyr Leu Ala Lys His Ser Gly Arg Gln Leu Xaa Leu Gln His 
        515                 520                 525             


His Met Gly Ser Ala Asp Leu Asn Ala Xaa Phe Tyr Gly Pro Val Lys 
    530                 535                 540                 


Lys Glu Asp Gly Ser Glu Val Gly Val Gly Gly Ala Gln Val Xaa Gly 
545                 550                 555                 560 


Ser Asn Xaa Arg Lys His Ile Leu Gln Val Ser Xaa Phe Gln Met Xaa 
                565                 570                 575     


Ile Leu Met Leu Phe Asn Asn Arg Glu Lys Tyr Xaa Phe Glu Glu Ile 
            580                 585                 590         


Gln Gln Glu Xaa Asp Ile Pro Glu Arg Glu Leu Val Arg Ala Leu Gln 
        595                 600                 605             


Ser Leu Ala Cys Gly Lys Pro Xaa Gln Arg Val Leu Xaa Lys Glu Pro 
    610                 615                 620                 


Lys Ser Lys Glu Ile Glu Asn Gly His Ile Phe Xaa Val Asn Asp Gln 
625                 630                 635                 640 


Phe Xaa Ser Lys Leu His Arg Val Lys Ile Gln Xaa Val Ala Ala Lys 
                645                 650                 655     


Gln Gly Glu Ser Asp Pro Glu Arg Lys Glu Xaa Arg Gln Lys Val Asp 
            660                 665                 670         


Asp Asp Arg Lys His Glu Ile Glu Ala Ala Ile Val Arg Ile Met Lys 
        675                 680                 685             


Ser Arg Lys Lys Met Gln His Asn Val Leu Val Ala Glu Val Xaa Gln 
    690                 695                 700                 


Gln Leu Lys Ala Arg Phe Leu Pro Ser Pro Val Val Ile Lys Lys Arg 
705                 710                 715                 720 


Ile Glu Gly Leu Ile Glu Arg Glu Tyr Leu Ala Arg Xaa Pro Glu Asp 
                725                 730                 735     


Arg Lys Val Tyr Xaa Tyr Val Ala 
            740                 


<210> 7337
<211> 768
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (587)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<400> 7337
Met Ser Asn Leu Ser Lys Gly Xaa Gly Ser Arg Lys Asp Xaa Lys Met 
1               5                   10                  15      


Arg Ile Arg Ala Phe Pro Met Xaa Met Asp Glu Lys Tyr Val Asn Ser 
            20                  25                  30          


Ile Trp Asp Leu Leu Lys Asn Ala Ile Gln Glu Ile Gln Arg Lys Asn 
        35                  40                  45              


Asn Ser Gly Leu Ser Phe Glu Glu Leu Tyr Arg Asn Ala Tyr Xaa Met 
    50                  55                  60                  


Val Leu His Lys His Gly Glu Lys Leu Tyr Xaa Gly Leu Arg Glu Val 
65                  70                  75                  80  


Val Xaa Glu His Leu Ile Asn Lys Val Arg Glu Asp Val Leu Asn Ser 
                85                  90                  95      


Leu Asn Asn Asn Phe Leu Gln Xaa Leu Asn Gln Ala Trp Asn Asp His 
            100                 105                 110         


Gln Xaa Ala Met Val Met Ile Arg Asp Ile Leu Met Tyr Met Asp Arg 
        115                 120                 125             


Val Tyr Val Gln Gln Asn Asn Val Glu Asn Val Tyr Asn Leu Gly Leu 
    130                 135                 140                 


Ile Ile Phe Arg Asp Gln Val Val Arg Tyr Gly Cys Ile Arg Asp His 
145                 150                 155                 160 


Leu Arg Gln Xaa Leu Leu Asp Met Ile Ala Arg Glu Arg Lys Gly Glu 
                165                 170                 175     


Val Val Asp Arg Gly Ala Ile Arg Asn Ala Cys Gln Met Leu Met Ile 
            180                 185                 190         


Leu Gly Leu Glu Gly Arg Ser Val Tyr Glu Glu Asp Phe Glu Ala Pro 
        195                 200                 205             


Phe Leu Glu Met Ser Ala Glu Phe Phe Gln Met Glu Ser Gln Lys Phe 
    210                 215                 220                 


Leu Ala Glu Asn Ser Ala Ser Val Tyr Ile Lys Lys Val Glu Ala Arg 
225                 230                 235                 240 


Ile Asn Glu Glu Ile Glu Arg Val Met His Cys Leu Asp Lys Ser Xaa 
                245                 250                 255     


Glu Glu Pro Ile Val Lys Val Val Glu Arg Glu Leu Ile Ser Lys His 
            260                 265                 270         


Met Lys Xaa Ile Val Glu Met Glu Asn Ser Gly Leu Val His Met Leu 
        275                 280                 285             


Lys Asn Gly Lys Xaa Glu Asp Leu Gly Cys Met Tyr Lys Leu Phe Ser 
    290                 295                 300                 


Arg Val Pro Asn Gly Leu Lys Xaa Met Cys Glu Cys Met Ser Ser Tyr 
305                 310                 315                 320 


Leu Arg Glu Gln Gly Lys Ala Leu Val Ser Glu Glu Gly Glu Gly Lys 
                325                 330                 335     


Asn Pro Val Asp Tyr Ile Gln Gly Leu Leu Asp Leu Lys Ser Arg Phe 
            340                 345                 350         


Asp Arg Phe Leu Leu Glu Ser Phe Asn Asn Asp Arg Leu Phe Lys Gln 
        355                 360                 365             


Xaa Ile Ala Gly Asp Phe Glu Tyr Phe Leu Asn Leu Asn Ser Arg Ser 
    370                 375                 380                 


Pro Glu Tyr Leu Ser Leu Phe Ile Asp Asp Lys Leu Lys Lys Gly Val 
385                 390                 395                 400 


Lys Gly Leu Xaa Glu Gln Glu Val Glu Xaa Ile Leu Asp Lys Ala Met 
                405                 410                 415     


Val Leu Phe Arg Phe Met Gln Glu Lys Asp Val Phe Glu Arg Tyr Tyr 
            420                 425                 430         


Lys Gln His Leu Ala Arg Arg Leu Leu Xaa Asn Lys Ser Val Ser Asp 
        435                 440                 445             


Asp Ser Glu Lys Asn Met Ile Ser Lys Leu Lys Xaa Glu Cys Gly Cys 
    450                 455                 460                 


Gln Phe Xaa Ser Lys Leu Glu Gly Met Phe Arg Asp Met Ser Ile Ser 
465                 470                 475                 480 


Asn Xaa Xaa Met Asp Glu Phe Arg Gln His Leu Gln Ala Xaa Gly Val 
                485                 490                 495     


Ser Leu Gly Gly Val Asp Leu Xaa Val Arg Val Leu Xaa Xaa Gly Tyr 
            500                 505                 510         


Trp Pro Xaa Gln Ser Ala Xaa Pro Lys Cys Asn Ile Pro Pro Ala Pro 
        515                 520                 525             


Arg His Ala Phe Glu Ile Phe Arg Arg Phe Tyr Leu Ala Lys His Ser 
    530                 535                 540                 


Gly Arg Gln Leu Xaa Leu Gln His His Met Gly Ser Ala Asp Leu Asn 
545                 550                 555                 560 


Ala Xaa Phe Tyr Gly Pro Val Lys Lys Glu Asp Gly Ser Glu Val Gly 
                565                 570                 575     


Val Gly Gly Ala Gln Val Xaa Gly Ser Asn Xaa Arg Lys His Ile Leu 
            580                 585                 590         


Gln Val Ser Xaa Phe Gln Met Xaa Ile Leu Met Leu Phe Asn Asn Arg 
        595                 600                 605             


Glu Lys Tyr Xaa Phe Glu Glu Ile Gln Gln Glu Xaa Asp Ile Pro Glu 
    610                 615                 620                 


Arg Glu Leu Val Arg Ala Leu Gln Ser Leu Ala Cys Gly Lys Pro Xaa 
625                 630                 635                 640 


Gln Arg Val Leu Xaa Lys Glu Pro Lys Ser Lys Glu Ile Glu Asn Gly 
                645                 650                 655     


His Ile Phe Xaa Val Asn Asp Gln Phe Xaa Ser Lys Leu His Arg Val 
            660                 665                 670         


Lys Ile Gln Xaa Val Ala Ala Lys Gln Gly Glu Ser Asp Pro Glu Arg 
        675                 680                 685             


Lys Glu Xaa Arg Gln Lys Val Asp Asp Asp Arg Lys His Glu Ile Glu 
    690                 695                 700                 


Ala Ala Ile Val Arg Ile Met Lys Ser Arg Lys Lys Met Gln His Asn 
705                 710                 715                 720 


Val Leu Val Ala Glu Val Xaa Gln Gln Leu Lys Ala Arg Phe Leu Pro 
                725                 730                 735     


Ser Pro Val Val Ile Lys Lys Arg Ile Glu Gly Leu Ile Glu Arg Glu 
            740                 745                 750         


Tyr Leu Ala Arg Xaa Pro Glu Asp Arg Lys Val Tyr Xaa Tyr Val Ala 
        755                 760                 765             


<210> 7338
<211> 702
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (594)..(594)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (610)..(610)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<400> 7338
Met Ser Asn Leu Ser Lys Gly Xaa Gly Ser Arg Lys Asp Xaa Lys Met 
1               5                   10                  15      


Arg Ile Arg Ala Phe Pro Val Arg Glu Asp Val Leu Asn Ser Leu Asn 
            20                  25                  30          


Asn Asn Phe Leu Gln Xaa Leu Asn Gln Ala Trp Asn Asp His Gln Xaa 
        35                  40                  45              


Ala Met Val Met Ile Arg Asp Ile Leu Met Tyr Met Asp Arg Val Tyr 
    50                  55                  60                  


Val Gln Gln Asn Asn Val Glu Asn Val Tyr Asn Leu Gly Leu Ile Ile 
65                  70                  75                  80  


Phe Arg Asp Gln Val Val Arg Tyr Gly Cys Ile Arg Asp His Leu Arg 
                85                  90                  95      


Gln Xaa Leu Leu Asp Met Ile Ala Arg Glu Arg Lys Gly Glu Val Val 
            100                 105                 110         


Asp Arg Gly Ala Ile Arg Asn Ala Cys Gln Met Leu Met Ile Leu Gly 
        115                 120                 125             


Leu Glu Gly Arg Ser Val Tyr Glu Glu Asp Phe Glu Ala Pro Phe Leu 
    130                 135                 140                 


Glu Met Ser Ala Glu Phe Phe Gln Met Glu Ser Gln Lys Phe Leu Ala 
145                 150                 155                 160 


Glu Asn Ser Ala Ser Val Tyr Ile Lys Lys Val Glu Ala Arg Ile Asn 
                165                 170                 175     


Glu Glu Ile Glu Arg Val Met His Cys Leu Asp Lys Ser Xaa Glu Glu 
            180                 185                 190         


Pro Ile Val Lys Val Val Glu Arg Glu Leu Ile Ser Lys His Met Lys 
        195                 200                 205             


Xaa Ile Val Glu Met Glu Asn Ser Gly Leu Val His Met Leu Lys Asn 
    210                 215                 220                 


Gly Lys Xaa Glu Asp Leu Gly Cys Met Tyr Lys Leu Phe Ser Arg Val 
225                 230                 235                 240 


Pro Asn Gly Leu Lys Xaa Met Cys Glu Cys Met Ser Ser Tyr Leu Arg 
                245                 250                 255     


Glu Gln Gly Lys Ala Leu Val Ser Glu Glu Gly Glu Gly Lys Asn Pro 
            260                 265                 270         


Val Asp Tyr Ile Gln Gly Leu Leu Asp Leu Lys Ser Arg Phe Asp Arg 
        275                 280                 285             


Phe Leu Leu Glu Ser Phe Asn Asn Asp Arg Leu Phe Lys Gln Xaa Ile 
    290                 295                 300                 


Ala Gly Asp Phe Glu Tyr Phe Leu Asn Leu Asn Ser Arg Ser Pro Glu 
305                 310                 315                 320 


Tyr Leu Ser Leu Phe Ile Asp Asp Lys Leu Lys Lys Gly Val Lys Gly 
                325                 330                 335     


Leu Xaa Glu Gln Glu Val Glu Xaa Ile Leu Asp Lys Ala Met Val Leu 
            340                 345                 350         


Phe Arg Phe Met Gln Glu Lys Asp Val Phe Glu Arg Tyr Tyr Lys Gln 
        355                 360                 365             


His Leu Ala Arg Arg Leu Leu Xaa Asn Lys Ser Val Ser Asp Asp Ser 
    370                 375                 380                 


Glu Lys Asn Met Ile Ser Lys Leu Lys Xaa Glu Cys Gly Cys Gln Phe 
385                 390                 395                 400 


Xaa Ser Lys Leu Glu Gly Met Phe Arg Asp Met Ser Ile Ser Asn Xaa 
                405                 410                 415     


Xaa Met Asp Glu Phe Arg Gln His Leu Gln Ala Xaa Gly Val Ser Leu 
            420                 425                 430         


Gly Gly Val Asp Leu Xaa Val Arg Val Leu Xaa Xaa Gly Tyr Trp Pro 
        435                 440                 445             


Xaa Gln Ser Ala Xaa Pro Lys Cys Asn Ile Pro Pro Ala Pro Arg His 
    450                 455                 460                 


Ala Phe Glu Ile Phe Arg Arg Phe Tyr Leu Ala Lys His Ser Gly Arg 
465                 470                 475                 480 


Gln Leu Xaa Leu Gln His His Met Gly Ser Ala Asp Leu Asn Ala Xaa 
                485                 490                 495     


Phe Tyr Gly Pro Val Lys Lys Glu Asp Gly Ser Glu Val Gly Val Gly 
            500                 505                 510         


Gly Ala Gln Val Xaa Gly Ser Asn Xaa Arg Lys His Ile Leu Gln Val 
        515                 520                 525             


Ser Xaa Phe Gln Met Xaa Ile Leu Met Leu Phe Asn Asn Arg Glu Lys 
    530                 535                 540                 


Tyr Xaa Phe Glu Glu Ile Gln Gln Glu Xaa Asp Ile Pro Glu Arg Glu 
545                 550                 555                 560 


Leu Val Arg Ala Leu Gln Ser Leu Ala Cys Gly Lys Pro Xaa Gln Arg 
                565                 570                 575     


Val Leu Xaa Lys Glu Pro Lys Ser Lys Glu Ile Glu Asn Gly His Ile 
            580                 585                 590         


Phe Xaa Val Asn Asp Gln Phe Xaa Ser Lys Leu His Arg Val Lys Ile 
        595                 600                 605             


Gln Xaa Val Ala Ala Lys Gln Gly Glu Ser Asp Pro Glu Arg Lys Glu 
    610                 615                 620                 


Xaa Arg Gln Lys Val Asp Asp Asp Arg Lys His Glu Ile Glu Ala Ala 
625                 630                 635                 640 


Ile Val Arg Ile Met Lys Ser Arg Lys Lys Met Gln His Asn Val Leu 
                645                 650                 655     


Val Ala Glu Val Xaa Gln Gln Leu Lys Ala Arg Phe Leu Pro Ser Pro 
            660                 665                 670         


Val Val Ile Lys Lys Arg Ile Glu Gly Leu Ile Glu Arg Glu Tyr Leu 
        675                 680                 685             


Ala Arg Xaa Pro Glu Asp Arg Lys Val Tyr Xaa Tyr Val Ala 
    690                 695                 700         


<210> 7339
<211> 342
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (331)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<400> 7339
Met Tyr Leu Asn Val Ile Ile Asn Asn Xaa Trp Gln Gly Asp Phe Ser 
1               5                   10                  15      


Gln Ile Lys Val Phe Leu Met Xaa Leu Lys Asn Met Ile Ser Lys Leu 
            20                  25                  30          


Lys Xaa Glu Cys Gly Cys Gln Phe Xaa Ser Lys Leu Glu Gly Met Phe 
        35                  40                  45              


Arg Asp Met Ser Ile Ser Asn Xaa Xaa Met Asp Glu Phe Arg Gln His 
    50                  55                  60                  


Leu Gln Ala Xaa Gly Val Ser Leu Gly Gly Val Asp Leu Xaa Val Arg 
65                  70                  75                  80  


Val Leu Xaa Xaa Gly Tyr Trp Pro Xaa Gln Ser Ala Xaa Pro Lys Cys 
                85                  90                  95      


Asn Ile Pro Pro Ala Pro Arg His Ala Phe Glu Ile Phe Arg Arg Phe 
            100                 105                 110         


Tyr Leu Ala Lys His Ser Gly Arg Gln Leu Xaa Leu Gln His His Met 
        115                 120                 125             


Gly Ser Ala Asp Leu Asn Ala Xaa Phe Tyr Gly Pro Val Lys Lys Glu 
    130                 135                 140                 


Asp Gly Ser Glu Val Gly Val Gly Gly Ala Gln Val Xaa Gly Ser Asn 
145                 150                 155                 160 


Xaa Arg Lys His Ile Leu Gln Val Ser Xaa Phe Gln Met Xaa Ile Leu 
                165                 170                 175     


Met Leu Phe Asn Asn Arg Glu Lys Tyr Xaa Phe Glu Glu Ile Gln Gln 
            180                 185                 190         


Glu Xaa Asp Ile Pro Glu Arg Glu Leu Val Arg Ala Leu Gln Ser Leu 
        195                 200                 205             


Ala Cys Gly Lys Pro Xaa Gln Arg Val Leu Xaa Lys Glu Pro Lys Ser 
    210                 215                 220                 


Lys Glu Ile Glu Asn Gly His Ile Phe Xaa Val Asn Asp Gln Phe Xaa 
225                 230                 235                 240 


Ser Lys Leu His Arg Val Lys Ile Gln Xaa Val Ala Ala Lys Gln Gly 
                245                 250                 255     


Glu Ser Asp Pro Glu Arg Lys Glu Xaa Arg Gln Lys Val Asp Asp Asp 
            260                 265                 270         


Arg Lys His Glu Ile Glu Ala Ala Ile Val Arg Ile Met Lys Ser Arg 
        275                 280                 285             


Lys Lys Met Gln His Asn Val Leu Val Ala Glu Val Xaa Gln Gln Leu 
    290                 295                 300                 


Lys Ala Arg Phe Leu Pro Ser Pro Val Val Ile Lys Lys Arg Ile Glu 
305                 310                 315                 320 


Gly Leu Ile Glu Arg Glu Tyr Leu Ala Arg Xaa Pro Glu Asp Arg Lys 
                325                 330                 335     


Val Tyr Xaa Tyr Val Ala 
            340         


<210> 7340
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<400> 7340
Xaa Leu Xaa Leu Gln His His Met Gly Ser Ala Asp Leu Asn Ala Xaa 
1               5                   10                  15      


Phe Tyr Gly Pro Val Lys Lys Glu Asp Gly Ser Glu Val Gly Val Gly 
            20                  25                  30          


Gly Ala Gln Val Xaa Gly Ser Asn Xaa Arg Lys His Ile Leu Gln Val 
        35                  40                  45              


Ser Xaa Phe Gln Met Xaa Ile Leu Met Leu Phe Asn Asn Arg Glu Lys 
    50                  55                  60                  


Tyr Xaa Phe Glu Val Xaa Gln Gln Leu Lys Ala Arg Phe Leu Pro Ser 
65                  70                  75                  80  


Pro Val Val Ile Lys Lys Arg Ile Glu Gly Leu Ile Glu Arg Glu Tyr 
                85                  90                  95      


Leu Ala Arg Xaa Pro Glu Asp Arg Lys Val Tyr Xaa Tyr Val Ala 
            100                 105                 110     


<210> 7341
<211> 192
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<400> 7341
Xaa Val Glu Ser Asp Lys Ser Gln Gly Gln Ser Ser Gln Gly Glu Asn 
1               5                   10                  15      


Asp Leu Asn Gly Ser Gly Lys Val Val Tyr Lys Arg Cys Arg Gly Ile 
            20                  25                  30          


Met Phe Ser Lys Arg Lys Leu Arg Tyr Xaa Glu Met Xaa Met Asp Glu 
        35                  40                  45              


Lys Tyr Val Asn Ser Ile Trp Asp Leu Leu Lys Asn Ala Ile Gln Glu 
    50                  55                  60                  


Ile Gln Arg Lys Asn Asn Ser Gly Leu Ser Phe Glu Glu Leu Tyr Arg 
65                  70                  75                  80  


Asn Ala Tyr Xaa Met Val Leu His Lys His Gly Glu Lys Leu Tyr Xaa 
                85                  90                  95      


Gly Leu Arg Glu Val Val Xaa Glu His Leu Ile Asn Lys Val Arg Glu 
            100                 105                 110         


Asp Val Leu Asn Ser Leu Asn Asn Asn Phe Leu Gln Xaa Leu Asn Gln 
        115                 120                 125             


Ala Trp Asn Asp His Gln Xaa Ala Met Val Met Ile Arg Asp Ile Leu 
    130                 135                 140                 


Met Tyr Met Asp Arg Val Tyr Val Gln Gln Asn Asn Val Glu Asn Val 
145                 150                 155                 160 


Tyr Asn Leu Gly Leu Ile Ile Phe Arg Asp Gln Val Val Arg Tyr Gly 
                165                 170                 175     


Cys Ile Arg Asp His Leu Arg Gln Xaa Leu Leu Asp Met Ile Ala Arg 
            180                 185                 190         


<210> 7342
<211> 174
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<400> 7342
Met Ala Asp Glu Ala Pro Arg Lys Gly Ser Phe Ser Ala Leu Val Gly 
1               5                   10                  15      


Arg Xaa Asn Gly Leu Xaa Lys Pro Ala Ala Leu Ala Ala Ala Pro Ala 
            20                  25                  30          


Lys Pro Gly Gly Ala Gly Gly Ser Lys Lys Leu Val Ile Lys Asn Phe 
        35                  40                  45              


Arg Asp Arg Pro Arg Leu Pro Asp Asn Tyr Xaa Gln Asp Xaa Trp Arg 
    50                  55                  60                  


Lys Leu His Glu Ala Val Arg Ala Val Gln Ser Ser Xaa Ser Ile Arg 
65                  70                  75                  80  


Tyr Asn Leu Glu Glu Leu Tyr Gln Ala Val Glu Asn Leu Cys Ser His 
                85                  90                  95      


Lys Val Ser Pro Met Leu Tyr Lys Gln Leu Arg Gln Ala Cys Glu Asp 
            100                 105                 110         


His Val Gln Ala Gln Ile Leu Pro Phe Arg Glu Asp Ser Leu Asp Ser 
        115                 120                 125             


Val Leu Phe Leu Lys Lys Ile Asn Xaa Cys Trp Gln Asp His Cys Arg 
    130                 135                 140                 


Gln Met Ile Met Ile Arg Ser Ile Phe Leu Phe Leu Asp Arg Xaa Tyr 
145                 150                 155                 160 


Val Leu Gln Asn Ser Xaa Leu Pro Ser Ile Cys Gln Asn His 
                165                 170                 


<210> 7343
<211> 759
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (349)..(349)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<400> 7343
Met Ala Asp Glu Ala Pro Arg Lys Gly Ser Phe Ser Ala Leu Val Gly 
1               5                   10                  15      


Arg Xaa Asn Gly Leu Xaa Lys Pro Ala Ala Leu Ala Ala Ala Pro Ala 
            20                  25                  30          


Lys Pro Gly Gly Ala Gly Gly Ser Lys Lys Leu Val Ile Lys Asn Phe 
        35                  40                  45              


Arg Asp Arg Pro Arg Leu Pro Asp Asn Tyr Xaa Gln Asp Xaa Trp Arg 
    50                  55                  60                  


Lys Leu His Glu Ala Val Arg Ala Val Gln Ser Ser Xaa Ser Ile Arg 
65                  70                  75                  80  


Tyr Asn Leu Glu Glu Leu Tyr Gln Ala Val Glu Asn Leu Cys Ser His 
                85                  90                  95      


Lys Val Ser Pro Met Leu Tyr Lys Gln Leu Arg Gln Ala Cys Glu Asp 
            100                 105                 110         


His Val Gln Ala Gln Ile Leu Pro Phe Arg Glu Asp Ser Leu Asp Ser 
        115                 120                 125             


Val Leu Phe Leu Lys Lys Ile Asn Xaa Cys Trp Gln Asp His Cys Arg 
    130                 135                 140                 


Gln Met Ile Met Ile Arg Ser Ile Phe Leu Phe Leu Asp Arg Xaa Tyr 
145                 150                 155                 160 


Val Leu Gln Asn Ser Xaa Leu Pro Ser Ile Trp Asp Met Gly Leu Glu 
                165                 170                 175     


Leu Phe Arg Xaa His Ile Ile Ser Asp Lys Met Val Gln Ser Lys Xaa 
            180                 185                 190         


Ile Asp Gly Ile Leu Leu Leu Ile Glu Arg Glu Arg Ser Gly Glu Ala 
        195                 200                 205             


Val Asp Arg Ser Leu Leu Arg Ser Leu Leu Gly Met Leu Ser Asp Leu 
    210                 215                 220                 


Gln Val Tyr Lys Asp Ser Phe Glu Leu Lys Phe Leu Glu Glu Xaa Asn 
225                 230                 235                 240 


Cys Leu Tyr Ala Ala Glu Gly Gln Arg Leu Met Gln Glu Arg Glu Val 
                245                 250                 255     


Pro Glu Tyr Leu Asn His Val Ser Lys Arg Leu Glu Glu Glu Gly Asp 
            260                 265                 270         


Arg Val Ile Xaa Tyr Leu Asp His Ser Xaa Gln Lys Pro Leu Ile Ala 
        275                 280                 285             


Cys Val Glu Lys Gln Leu Leu Gly Glu His Leu Xaa Ala Ile Leu Gln 
    290                 295                 300                 


Lys Gly Leu Asp His Leu Leu Asp Glu Asn Arg Val Pro Asp Leu Ala 
305                 310                 315                 320 


Gln Met Tyr Gln Leu Phe Ser Arg Val Arg Gly Gly Gln Gln Ala Leu 
                325                 330                 335     


Leu Gln His Trp Ser Glu Tyr Ile Lys Xaa Phe Gly Xaa Ala Ile Val 
            340                 345                 350         


Ile Asn Pro Glu Lys Asp Lys Asp Met Val Gln Asp Leu Leu Asp Phe 
        355                 360                 365             


Lys Asp Lys Val Asp His Val Ile Glu Val Cys Phe Gln Lys Asn Glu 
    370                 375                 380                 


Arg Phe Val Asn Leu Met Lys Glu Ser Phe Glu Xaa Phe Ile Asn Lys 
385                 390                 395                 400 


Arg Pro Asn Lys Pro Ala Glu Leu Ile Ala Lys His Val Asp Ser Lys 
                405                 410                 415     


Leu Arg Ala Gly Asn Lys Glu Ala Xaa Asp Glu Glu Leu Glu Arg Xaa 
            420                 425                 430         


Leu Asp Lys Ile Met Ile Leu Phe Arg Phe Ile His Gly Lys Asp Val 
        435                 440                 445             


Phe Glu Ala Phe Tyr Lys Lys Asp Leu Ala Lys Arg Leu Leu Val Gly 
    450                 455                 460                 


Lys Ser Ala Ser Val Asp Ala Glu Lys Ser Met Leu Ser Lys Leu Lys 
465                 470                 475                 480 


His Glu Cys Gly Ala Ala Phe Xaa Ser Lys Leu Glu Gly Met Phe Lys 
                485                 490                 495     


Asp Met Glu Leu Ser Lys Asp Ile Met Val His Phe Lys Gln His Met 
            500                 505                 510         


Gln Asn Gln Ser Asp Ser Gly Pro Ile Asp Leu Xaa Val Asn Ile Leu 
        515                 520                 525             


Xaa Met Gly Tyr Trp Pro Xaa Tyr Xaa Pro Met Glu Val His Leu Xaa 
    530                 535                 540                 


Pro Glu Met Ile Lys Leu Gln Glu Val Phe Lys Ala Phe Tyr Leu Gly 
545                 550                 555                 560 


Lys His Ser Gly Arg Lys Leu Gln Trp Gln Xaa Xaa Leu Gly His Ala 
                565                 570                 575     


Val Leu Lys Ala Glu Phe Lys Glu Gly Lys Lys Glu Phe Gln Val Ser 
            580                 585                 590         


Leu Phe Gln Xaa Leu Val Leu Leu Met Phe Asn Glu Gly Asp Gly Phe 
        595                 600                 605             


Ser Phe Glu Glu Ile Lys Met Ala Xaa Gly Ile Glu Asp Ser Glu Leu 
    610                 615                 620                 


Arg Arg Xaa Leu Gln Ser Leu Ala Cys Gly Lys Ala Arg Val Leu Ile 
625                 630                 635                 640 


Lys Ser Pro Lys Gly Lys Glu Val Glu Asp Gly Asp Lys Phe Ile Phe 
                645                 650                 655     


Asn Gly Glu Phe Lys His Lys Leu Phe Arg Ile Lys Ile Asn Gln Ile 
            660                 665                 670         


Gln Met Lys Glu Xaa Val Glu Glu Gln Val Ser Xaa Xaa Glu Arg Val 
        675                 680                 685             


Phe Gln Asp Arg Gln Tyr Gln Ile Asp Ala Ala Ile Val Arg Ile Met 
    690                 695                 700                 


Lys Met Arg Lys Xaa Leu Gly His Asn Leu Leu Val Ser Glu Leu Tyr 
705                 710                 715                 720 


Asn Gln Leu Lys Phe Pro Val Lys Pro Gly Asp Leu Lys Lys Arg Ile 
                725                 730                 735     


Glu Ser Leu Ile Asp Arg Asp Tyr Met Glu Arg Asp Lys Asp Asn Pro 
            740                 745                 750         


Asn Gln Tyr His Tyr Val Ala 
        755                 


<210> 7344
<211> 667
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (592)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<400> 7344
Met Leu Tyr Lys Gln Leu Arg Gln Ala Cys Glu Asp His Val Gln Ala 
1               5                   10                  15      


Gln Ile Leu Pro Phe Arg Glu Asp Ser Leu Asp Ser Val Leu Phe Leu 
            20                  25                  30          


Lys Lys Ile Asn Xaa Cys Trp Gln Asp His Cys Arg Gln Met Ile Met 
        35                  40                  45              


Ile Arg Ser Ile Phe Leu Phe Leu Asp Arg Xaa Tyr Val Leu Gln Asn 
    50                  55                  60                  


Ser Xaa Leu Pro Ser Ile Cys Pro Val Ser Tyr Cys Leu Tyr Arg Asp 
65                  70                  75                  80  


Met Gly Leu Glu Leu Phe Arg Xaa His Ile Ile Ser Asp Lys Met Val 
                85                  90                  95      


Gln Ser Lys Xaa Ile Asp Gly Ile Leu Leu Leu Ile Glu Arg Glu Arg 
            100                 105                 110         


Ser Gly Glu Ala Val Asp Arg Ser Leu Leu Arg Ser Leu Leu Gly Met 
        115                 120                 125             


Leu Ser Asp Leu Gln Val Tyr Lys Asp Ser Phe Glu Leu Lys Phe Leu 
    130                 135                 140                 


Glu Glu Xaa Asn Cys Leu Tyr Ala Ala Glu Gly Gln Arg Leu Met Gln 
145                 150                 155                 160 


Glu Arg Glu Val Pro Glu Tyr Leu Asn His Val Ser Lys Arg Leu Glu 
                165                 170                 175     


Glu Glu Gly Asp Arg Val Ile Xaa Tyr Leu Asp His Ser Xaa Gln Lys 
            180                 185                 190         


Pro Leu Ile Ala Cys Val Glu Lys Gln Leu Leu Gly Glu His Leu Xaa 
        195                 200                 205             


Ala Ile Leu Gln Lys Gly Leu Asp His Leu Leu Asp Glu Asn Arg Val 
    210                 215                 220                 


Pro Asp Leu Ala Gln Met Tyr Gln Leu Phe Ser Arg Val Arg Gly Gly 
225                 230                 235                 240 


Gln Gln Ala Leu Leu Gln His Trp Ser Glu Tyr Ile Lys Xaa Phe Gly 
                245                 250                 255     


Xaa Ala Ile Val Ile Asn Pro Glu Lys Asp Lys Asp Met Val Gln Asp 
            260                 265                 270         


Leu Leu Asp Phe Lys Asp Lys Val Asp His Val Ile Glu Val Cys Phe 
        275                 280                 285             


Gln Lys Asn Glu Arg Phe Val Asn Leu Met Lys Glu Ser Phe Glu Xaa 
    290                 295                 300                 


Phe Ile Asn Lys Arg Pro Asn Lys Pro Ala Glu Leu Ile Ala Lys His 
305                 310                 315                 320 


Val Asp Ser Lys Leu Arg Ala Gly Asn Lys Glu Ala Xaa Asp Glu Glu 
                325                 330                 335     


Leu Glu Arg Xaa Leu Asp Lys Ile Met Ile Leu Phe Arg Phe Ile His 
            340                 345                 350         


Gly Lys Asp Val Phe Glu Ala Phe Tyr Lys Lys Asp Leu Ala Lys Arg 
        355                 360                 365             


Leu Leu Val Gly Lys Ser Ala Ser Val Asp Ala Glu Lys Ser Met Leu 
    370                 375                 380                 


Ser Lys Leu Lys His Glu Cys Gly Ala Ala Phe Xaa Ser Lys Leu Glu 
385                 390                 395                 400 


Gly Met Phe Lys Asp Met Glu Leu Ser Lys Asp Ile Met Val His Phe 
                405                 410                 415     


Lys Gln His Met Gln Asn Gln Ser Asp Ser Gly Pro Ile Asp Leu Xaa 
            420                 425                 430         


Val Asn Ile Leu Xaa Met Gly Tyr Trp Pro Xaa Tyr Xaa Pro Met Glu 
        435                 440                 445             


Val His Leu Xaa Pro Glu Met Ile Lys Leu Gln Glu Val Phe Lys Ala 
    450                 455                 460                 


Phe Tyr Leu Gly Lys His Ser Gly Arg Lys Leu Gln Trp Gln Xaa Xaa 
465                 470                 475                 480 


Leu Gly His Ala Val Leu Lys Ala Glu Phe Lys Glu Gly Lys Lys Glu 
                485                 490                 495     


Phe Gln Val Ser Leu Phe Gln Xaa Leu Val Leu Leu Met Phe Asn Glu 
            500                 505                 510         


Gly Asp Gly Phe Ser Phe Glu Glu Ile Lys Met Ala Xaa Gly Ile Glu 
        515                 520                 525             


Asp Ser Glu Leu Arg Arg Xaa Leu Gln Ser Leu Ala Cys Gly Lys Ala 
    530                 535                 540                 


Arg Val Leu Ile Lys Ser Pro Lys Gly Lys Glu Val Glu Asp Gly Asp 
545                 550                 555                 560 


Lys Phe Ile Phe Asn Gly Glu Phe Lys His Lys Leu Phe Arg Ile Lys 
                565                 570                 575     


Ile Asn Gln Ile Gln Met Lys Glu Xaa Val Glu Glu Gln Val Ser Xaa 
            580                 585                 590         


Xaa Glu Arg Val Phe Gln Asp Arg Gln Tyr Gln Ile Asp Ala Ala Ile 
        595                 600                 605             


Val Arg Ile Met Lys Met Arg Lys Xaa Leu Gly His Asn Leu Leu Val 
    610                 615                 620                 


Ser Glu Leu Tyr Asn Gln Leu Lys Phe Pro Val Lys Pro Gly Asp Leu 
625                 630                 635                 640 


Lys Lys Arg Ile Glu Ser Leu Ile Asp Arg Asp Tyr Met Glu Arg Asp 
                645                 650                 655     


Lys Asp Asn Pro Asn Gln Tyr His Tyr Val Ala 
            660                 665         


<210> 7345
<211> 659
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (496)..(496)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (577)..(577)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<400> 7345
Met Leu Tyr Lys Gln Leu Arg Gln Ala Cys Glu Asp His Val Gln Ala 
1               5                   10                  15      


Gln Ile Leu Pro Phe Arg Glu Asp Ser Leu Asp Ser Val Leu Phe Leu 
            20                  25                  30          


Lys Lys Ile Asn Xaa Cys Trp Gln Asp His Cys Arg Gln Met Ile Met 
        35                  40                  45              


Ile Arg Ser Ile Phe Leu Phe Leu Asp Arg Xaa Tyr Val Leu Gln Asn 
    50                  55                  60                  


Ser Xaa Leu Pro Ser Ile Trp Asp Met Gly Leu Glu Leu Phe Arg Xaa 
65                  70                  75                  80  


His Ile Ile Ser Asp Lys Met Val Gln Ser Lys Xaa Ile Asp Gly Ile 
                85                  90                  95      


Leu Leu Leu Ile Glu Arg Glu Arg Ser Gly Glu Ala Val Asp Arg Ser 
            100                 105                 110         


Leu Leu Arg Ser Leu Leu Gly Met Leu Ser Asp Leu Gln Val Tyr Lys 
        115                 120                 125             


Asp Ser Phe Glu Leu Lys Phe Leu Glu Glu Xaa Asn Cys Leu Tyr Ala 
    130                 135                 140                 


Ala Glu Gly Gln Arg Leu Met Gln Glu Arg Glu Val Pro Glu Tyr Leu 
145                 150                 155                 160 


Asn His Val Ser Lys Arg Leu Glu Glu Glu Gly Asp Arg Val Ile Xaa 
                165                 170                 175     


Tyr Leu Asp His Ser Xaa Gln Lys Pro Leu Ile Ala Cys Val Glu Lys 
            180                 185                 190         


Gln Leu Leu Gly Glu His Leu Xaa Ala Ile Leu Gln Lys Gly Leu Asp 
        195                 200                 205             


His Leu Leu Asp Glu Asn Arg Val Pro Asp Leu Ala Gln Met Tyr Gln 
    210                 215                 220                 


Leu Phe Ser Arg Val Arg Gly Gly Gln Gln Ala Leu Leu Gln His Trp 
225                 230                 235                 240 


Ser Glu Tyr Ile Lys Xaa Phe Gly Xaa Ala Ile Val Ile Asn Pro Glu 
                245                 250                 255     


Lys Asp Lys Asp Met Val Gln Asp Leu Leu Asp Phe Lys Asp Lys Val 
            260                 265                 270         


Asp His Val Ile Glu Val Cys Phe Gln Lys Asn Glu Arg Phe Val Asn 
        275                 280                 285             


Leu Met Lys Glu Ser Phe Glu Xaa Phe Ile Asn Lys Arg Pro Asn Lys 
    290                 295                 300                 


Pro Ala Glu Leu Ile Ala Lys His Val Asp Ser Lys Leu Arg Ala Gly 
305                 310                 315                 320 


Asn Lys Glu Ala Xaa Asp Glu Glu Leu Glu Arg Xaa Leu Asp Lys Ile 
                325                 330                 335     


Met Ile Leu Phe Arg Phe Ile His Gly Lys Asp Val Phe Glu Ala Phe 
            340                 345                 350         


Tyr Lys Lys Asp Leu Ala Lys Arg Leu Leu Val Gly Lys Ser Ala Ser 
        355                 360                 365             


Val Asp Ala Glu Lys Ser Met Leu Ser Lys Leu Lys His Glu Cys Gly 
    370                 375                 380                 


Ala Ala Phe Xaa Ser Lys Leu Glu Gly Met Phe Lys Asp Met Glu Leu 
385                 390                 395                 400 


Ser Lys Asp Ile Met Val His Phe Lys Gln His Met Gln Asn Gln Ser 
                405                 410                 415     


Asp Ser Gly Pro Ile Asp Leu Xaa Val Asn Ile Leu Xaa Met Gly Tyr 
            420                 425                 430         


Trp Pro Xaa Tyr Xaa Pro Met Glu Val His Leu Xaa Pro Glu Met Ile 
        435                 440                 445             


Lys Leu Gln Glu Val Phe Lys Ala Phe Tyr Leu Gly Lys His Ser Gly 
    450                 455                 460                 


Arg Lys Leu Gln Trp Gln Xaa Xaa Leu Gly His Ala Val Leu Lys Ala 
465                 470                 475                 480 


Glu Phe Lys Glu Gly Lys Lys Glu Phe Gln Val Ser Leu Phe Gln Xaa 
                485                 490                 495     


Leu Val Leu Leu Met Phe Asn Glu Gly Asp Gly Phe Ser Phe Glu Glu 
            500                 505                 510         


Ile Lys Met Ala Xaa Gly Ile Glu Asp Ser Glu Leu Arg Arg Xaa Leu 
        515                 520                 525             


Gln Ser Leu Ala Cys Gly Lys Ala Arg Val Leu Ile Lys Ser Pro Lys 
    530                 535                 540                 


Gly Lys Glu Val Glu Asp Gly Asp Lys Phe Ile Phe Asn Gly Glu Phe 
545                 550                 555                 560 


Lys His Lys Leu Phe Arg Ile Lys Ile Asn Gln Ile Gln Met Lys Glu 
                565                 570                 575     


Xaa Val Glu Glu Gln Val Ser Xaa Xaa Glu Arg Val Phe Gln Asp Arg 
            580                 585                 590         


Gln Tyr Gln Ile Asp Ala Ala Ile Val Arg Ile Met Lys Met Arg Lys 
        595                 600                 605             


Xaa Leu Gly His Asn Leu Leu Val Ser Glu Leu Tyr Asn Gln Leu Lys 
    610                 615                 620                 


Phe Pro Val Lys Pro Gly Asp Leu Lys Lys Arg Ile Glu Ser Leu Ile 
625                 630                 635                 640 


Asp Arg Asp Tyr Met Glu Arg Asp Lys Asp Asn Pro Asn Gln Tyr His 
                645                 650                 655     


Tyr Val Ala 
            


<210> 7346
<211> 780
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (661)..(661)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(696)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<400> 7346
Met Ala Xaa Ser Asn Leu Leu Lys Asn Lys Gly Ser Leu Gln Phe Glu 
1               5                   10                  15      


Asp Lys Trp Asp Phe Met Arg Pro Ile Val Leu Lys Leu Leu Arg Gln 
            20                  25                  30          


Glu Ser Val Xaa Lys Gln Gln Trp Phe Asp Leu Phe Ser Asp Val His 
        35                  40                  45              


Ala Val Cys Leu Trp Asp Asp Lys Gly Pro Ala Lys Ile His Gln Ala 
    50                  55                  60                  


Leu Lys Glu Asp Ile Leu Glu Phe Ile Lys Gln Ala Gln Ala Arg Val 
65                  70                  75                  80  


Leu Ser His Gln Asp Asp Xaa Ala Leu Leu Lys Ala Tyr Ile Val Glu 
                85                  90                  95      


Trp Arg Lys Phe Phe Xaa Gln Cys Asp Ile Leu Pro Lys Pro Phe Cys 
            100                 105                 110         


Gln Leu Glu Ile Xaa Leu Met Gly Lys Gln Gly Ser Asn Lys Lys Ser 
        115                 120                 125             


Asn Val Glu Asp Ser Ile Val Arg Lys Leu Met Leu Asp Xaa Trp Asn 
    130                 135                 140                 


Glu Ser Ile Phe Ser Asn Ile Lys Asn Arg Leu Gln Asp Ser Ala Met 
145                 150                 155                 160 


Lys Leu Val His Ala Glu Arg Leu Gly Glu Ala Phe Asp Ser Gln Leu 
                165                 170                 175     


Val Ile Gly Val Arg Glu Ser Tyr Val Asn Leu Cys Ser Asn Pro Glu 
            180                 185                 190         


Asp Lys Leu Gln Ile Tyr Arg Asp Asn Phe Glu Lys Ala Tyr Leu Asp 
        195                 200                 205             


Ser Xaa Glu Arg Phe Tyr Arg Xaa Gln Ala Pro Ser Tyr Leu Gln Gln 
    210                 215                 220                 


Asn Gly Val Gln Asn Tyr Met Lys Tyr Ala Asp Ala Lys Leu Lys Glu 
225                 230                 235                 240 


Glu Glu Lys Arg Ala Leu Arg Tyr Leu Glu Xaa Arg Arg Glu Cys Asn 
                245                 250                 255     


Ser Val Glu Ala Leu Met Glu Cys Cys Val Asn Ala Leu Val Xaa Ser 
            260                 265                 270         


Phe Lys Glu Xaa Ile Leu Ala Glu Cys Gln Gly Met Ile Lys Arg Asn 
        275                 280                 285             


Glu Xaa Glu Lys Leu His Leu Met Phe Ser Leu Met Asp Lys Val Pro 
    290                 295                 300                 


Asn Gly Ile Glu Pro Met Leu Lys Asp Leu Glu Glu His Ile Ile Ser 
305                 310                 315                 320 


Ala Gly Leu Ala Asp Met Val Ala Ala Ala Glu Xaa Ile Xaa Xaa Asp 
                325                 330                 335     


Ser Glu Lys Tyr Val Glu Gln Leu Leu Xaa Leu Phe Asn Arg Phe Ser 
            340                 345                 350         


Lys Leu Val Lys Glu Ala Phe Gln Asp Asp Pro Arg Phe Leu Xaa Ala 
        355                 360                 365             


Arg Asp Lys Ala Tyr Lys Ala Val Val Asn Asp Ala Xaa Ile Phe Lys 
    370                 375                 380                 


Leu Glu Leu Pro Leu Lys Gln Lys Gly Val Gly Leu Lys Xaa Gln Pro 
385                 390                 395                 400 


Glu Ser Lys Cys Pro Glu Leu Leu Ala Asn Tyr Cys Asp Met Leu Leu 
                405                 410                 415     


Arg Lys Xaa Pro Leu Ser Lys Lys Leu Xaa Ser Glu Glu Ile Glu Ala 
            420                 425                 430         


Lys Leu Lys Glu Val Leu Leu Val Leu Lys Tyr Val Gln Asn Lys Asp 
        435                 440                 445             


Val Phe Met Arg Tyr His Lys Ala His Leu Xaa Arg Arg Leu Ile Leu 
    450                 455                 460                 


Asp Ile Ser Ala Asp Ser Glu Ile Glu Glu Asn Met Val Glu Trp Leu 
465                 470                 475                 480 


Arg Glu Val Gly Met Pro Ala Asp Tyr Val Asn Lys Leu Ala Arg Met 
                485                 490                 495     


Phe Gln Asp Ile Lys Val Ser Glu Asp Leu Asn Gln Ala Phe Lys Glu 
            500                 505                 510         


Met His Lys Asn Asn Lys Leu Ala Leu Pro Ala Asp Ser Val Asn Ile 
        515                 520                 525             


Lys Ile Leu Asn Ala Gly Ala Trp Ser Arg Ser Ser Glu Lys Val Phe 
    530                 535                 540                 


Val Ser Leu Pro Xaa Glu Leu Glu Asp Leu Ile Pro Glu Val Glu Glu 
545                 550                 555                 560 


Phe Tyr Lys Lys Asn His Ser Gly Arg Lys Leu His Trp His His Leu 
                565                 570                 575     


Met Ser Asn Gly Ile Ile Xaa Phe Lys Asn Glu Val Gly Gln Tyr Asp 
            580                 585                 590         


Leu Glu Val Xaa Xaa Phe Gln Leu Ala Val Leu Phe Ala Trp Asn Gln 
        595                 600                 605             


Arg Pro Arg Glu Lys Ile Ser Phe Glu Asn Leu Lys Leu Ala Xaa Glu 
    610                 615                 620                 


Leu Pro Asp Ala Glu Leu Arg Arg Xaa Leu Trp Ser Leu Val Ala Phe 
625                 630                 635                 640 


Pro Lys Leu Lys Arg Gln Val Leu Leu Tyr Glu Pro Gln Val Asn Ser 
                645                 650                 655     


Pro Lys Asp Phe Xaa Glu Gly Xaa Leu Phe Ser Val Asn Gln Glu Phe 
            660                 665                 670         


Ser Leu Ile Lys Asn Ala Lys Val Gln Lys Arg Gly Lys Ile Asn Leu 
        675                 680                 685             


Ile Gly Arg Leu Gln Leu Xaa Xaa Glu Arg Met Arg Glu Glu Glu Asn 
    690                 695                 700                 


Glu Gly Ile Val Gln Leu Arg Ile Leu Arg Xaa Gln Glu Ala Ile Ile 
705                 710                 715                 720 


Gln Ile Met Lys Met Arg Lys Lys Ile Ser Asn Ala Gln Leu Gln Xaa 
                725                 730                 735     


Glu Leu Val Glu Ile Leu Lys Asn Met Phe Leu Pro Gln Lys Lys Met 
            740                 745                 750         


Ile Lys Glu Gln Ile Glu Trp Leu Ile Glu His Lys Tyr Ile Arg Arg 
        755                 760                 765             


Asp Glu Ser Asp Ile Asn Xaa Phe Ile Tyr Met Ala 
    770                 775                 780 


<210> 7347
<211> 47
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<400> 7347
Met Ala Xaa Ser Asn Leu Leu Lys Asn Lys Gly Ser Leu Gln Phe Glu 
1               5                   10                  15      


Asp Lys Trp Asp Phe Met Arg Pro Ile Val Leu Lys Leu Leu Arg Gln 
            20                  25                  30          


Glu Ser Val Xaa Lys Gln Gln Trp Phe Asp Leu Phe Ser Glu Tyr 
        35                  40                  45          


<210> 7348
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<400> 7348
Xaa Asp Val His Ala Val Cys Leu Trp Asp Asp Lys Gly Pro Ala Lys 
1               5                   10                  15      


Ile His Gln Ala Leu Lys Glu Asp Ile Leu Glu Phe Ile Lys Gln Ala 
            20                  25                  30          


Gln Ala Leu Met Leu Asp Xaa Trp Asn Glu Ser Ile Phe Ser Asn Ile 
        35                  40                  45              


Lys Asn Arg Leu Gln Asp Ser Ala Met Lys Leu Val His Ala Glu Arg 
    50                  55                  60                  


Leu Gly Glu Ala Phe Asp Ser Gln Leu Val Ile Gly Val Arg Glu Ser 
65                  70                  75                  80  


Tyr Val Asn Leu Cys Ser Asn Pro Glu Asp Lys Leu Gln Ile Tyr Arg 
                85                  90                  95      


Asp Asn Phe Glu Lys Ala Tyr Leu Asp Ser Xaa Glu Arg Phe Tyr Arg 
            100                 105                 110         


Xaa Gln Ala Pro Ser Tyr Leu Gln Gln Asn Gly Val Gln Asn Tyr Met 
        115                 120                 125             


Lys Tyr 
    130 


<210> 7349
<211> 639
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<400> 7349
Met Ala Ala Asn Val Gly Ser Met Phe Gln Tyr Trp Lys Arg Phe Asp 
1               5                   10                  15      


Leu Gln Gln Leu Gln Asp Leu Arg Lys Gln Val Ala Pro Leu Leu Lys 
            20                  25                  30          


Ser Phe Gln Gly Glu Ile Asp Ala Leu Ser Lys Arg Ser Lys Glu Ala 
        35                  40                  45              


Glu Ala Ala Phe Leu Asn Val Tyr Lys Arg Leu Ile Asp Val Pro Asp 
    50                  55                  60                  


Pro Val Pro Ala Leu Asp Leu Gly Gln Gln Leu Gln Leu Lys Val Gln 
65                  70                  75                  80  


Arg Leu His Asp Ile Glu Xaa Glu Asn Gln Lys Leu Arg Glu Xaa Leu 
                85                  90                  95      


Glu Glu Tyr Asn Lys Glu Phe Ala Glu Val Lys Asn Gln Glu Val Xaa 
            100                 105                 110         


Ile Lys Ala Leu Lys Glu Lys Ile Arg Glu Tyr Glu Gln Xaa Leu Lys 
        115                 120                 125             


Asn Gln Ala Glu Xaa Ile Ala Leu Glu Lys Glu Gln Lys Leu Gln Asn 
    130                 135                 140                 


Asp Phe Ala Glu Lys Glu Arg Lys Leu Gln Glu Xaa Gln Met Ser Xaa 
145                 150                 155                 160 


Xaa Ser Lys Leu Glu Glu Ala Glu His Lys Val Gln Ser Leu Gln Xaa 
                165                 170                 175     


Ala Leu Glu Lys Xaa Arg Xaa Glu Leu Phe Asp Leu Lys Xaa Lys Tyr 
            180                 185                 190         


Asp Glu Glu Xaa Xaa Ala Lys Ala Asp Glu Ile Glu Met Ile Met Xaa 
        195                 200                 205             


Asp Leu Glu Arg Ala Asn Gln Arg Ala Glu Val Ala Gln Arg Glu Ala 
    210                 215                 220                 


Glu Xaa Leu Arg Glu Gln Leu Ser Ser Ala Asn His Ser Leu Gln Leu 
225                 230                 235                 240 


Ala Ser Gln Ile Gln Lys Ala Pro Asp Val Ala Ile Glu Val Leu Xaa 
                245                 250                 255     


Arg Ser Ser Leu Glu Val Glu Leu Ala Ala Lys Glu Arg Glu Ile Ala 
            260                 265                 270         


Gln Leu Val Glu Asp Val Gln Arg Leu Gln Ala Ser Leu Xaa Lys Leu 
        275                 280                 285             


Arg Glu Asn Ser Ala Ser Gln Ile Ser Gln Leu Glu Gln Gln Leu Ser 
    290                 295                 300                 


Ala Lys Asn Ser Xaa Leu Lys Gln Leu Glu Glu Lys Leu Lys Gly Gln 
305                 310                 315                 320 


Ala Asp Tyr Glu Glu Val Lys Lys Glu Leu Asn Ile Leu Lys Ser Met 
                325                 330                 335     


Glu Phe Ala Pro Ser Glu Gly Ala Gly Xaa Gln Asp Ala Ala Lys Pro 
            340                 345                 350         


Leu Glu Val Leu Leu Leu Glu Lys Asn Arg Ser Leu Gln Ser Glu Asn 
        355                 360                 365             


Ala Ala Leu Arg Ile Ser Asn Ser Asp Leu Ser Gly Arg Cys Ala Glu 
    370                 375                 380                 


Leu Gln Val Arg Ile Xaa Glu Ala Val Ala Xaa Ala Xaa Glu Gln Arg 
385                 390                 395                 400 


Glu Leu Ile Ala Arg Leu Glu Gln Asp Leu Ser Ile Ile Gln Ser Ile 
                405                 410                 415     


Gln Arg Pro Asp Ala Glu Gly Ala Ala Glu His Arg Leu Glu Lys Ile 
            420                 425                 430         


Pro Glu Pro Ile Lys Glu Ala Xaa Ala Leu Phe Tyr Gly Pro Ala Ala 
        435                 440                 445             


Pro Ala Ser Gly Ala Leu Pro Glu Gly Gln Val Asp Ser Leu Leu Ser 
    450                 455                 460                 


Ile Ile Ser Ser Gln Arg Glu Arg Phe Arg Ala Arg Asn Gln Glu Leu 
465                 470                 475                 480 


Glu Ala Glu Asn Arg Leu Ala Gln His Xaa Leu Gln Ala Leu Gln Ser 
                485                 490                 495     


Glu Leu Asp Ser Leu Arg Ala Asp Asn Ile Lys Leu Phe Glu Lys Ile 
            500                 505                 510         


Lys Phe Leu Gln Ser Tyr Pro Gly Arg Gly Ser Gly Ser Asp Asp Xaa 
        515                 520                 525             


Glu Leu Arg Tyr Ser Ser Gln Tyr Glu Glu Arg Leu Asp Pro Phe Ser 
    530                 535                 540                 


Ser Phe Ser Lys Arg Glu Arg Gln Arg Lys Tyr Leu Ser Leu Ser Pro 
545                 550                 555                 560 


Trp Asp Lys Ala Xaa Leu Ser Met Gly Arg Leu Val Leu Ser Asn Lys 
                565                 570                 575     


Met Ala Arg Xaa Ile Gly Phe Phe Tyr Xaa Leu Phe Leu His Cys Leu 
            580                 585                 590         


Val Phe Leu Val Leu Tyr Lys Leu Ala Trp Ser Glu Ser Met Glu Arg 
        595                 600                 605             


Asp Cys Ala Xaa Phe Cys Ala Lys Lys Phe Ala Asp His Leu His Lys 
    610                 615                 620                 


Phe His Glu Asn Asp Asn Gly Ala Ala Ala Gly Asp Leu Trp Gln 
625                 630                 635                 


<210> 7350
<211> 676
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<400> 7350
Met Ala Ala Asn Val Gly Ser Met Phe Gln Tyr Trp Lys Arg Phe Asp 
1               5                   10                  15      


Leu Gln Gln Leu Gln Arg Glu Leu Asp Ala Xaa Ala Xaa Val Leu Ala 
            20                  25                  30          


Asn Arg Gln Asp Glu Ser Glu Gln Ser Arg Lys Arg Leu Ile Glu Gln 
        35                  40                  45              


Ser Arg Glu Phe Lys Lys Asn Xaa Pro Glu Asp Leu Arg Lys Gln Val 
    50                  55                  60                  


Ala Pro Leu Leu Lys Ser Phe Gln Gly Glu Ile Asp Ala Leu Ser Lys 
65                  70                  75                  80  


Arg Ser Lys Glu Ala Glu Ala Ala Phe Leu Asn Val Tyr Lys Arg Leu 
                85                  90                  95      


Ile Asp Val Pro Asp Pro Val Pro Ala Leu Asp Leu Gly Gln Gln Leu 
            100                 105                 110         


Gln Leu Lys Val Gln Arg Leu His Asp Ile Glu Xaa Glu Asn Gln Lys 
        115                 120                 125             


Leu Arg Glu Xaa Leu Glu Glu Tyr Asn Lys Glu Phe Ala Glu Val Lys 
    130                 135                 140                 


Asn Gln Glu Val Xaa Ile Lys Ala Leu Lys Glu Lys Ile Arg Glu Tyr 
145                 150                 155                 160 


Glu Gln Xaa Leu Lys Asn Gln Ala Glu Xaa Ile Ala Leu Glu Lys Glu 
                165                 170                 175     


Gln Lys Leu Gln Asn Asp Phe Ala Glu Lys Glu Arg Lys Leu Gln Glu 
            180                 185                 190         


Xaa Gln Met Ser Xaa Xaa Ser Lys Leu Glu Glu Ala Glu His Lys Val 
        195                 200                 205             


Gln Ser Leu Gln Xaa Ala Leu Glu Lys Xaa Arg Xaa Glu Leu Phe Asp 
    210                 215                 220                 


Leu Lys Xaa Lys Tyr Asp Glu Glu Xaa Xaa Ala Lys Ala Asp Glu Ile 
225                 230                 235                 240 


Glu Met Ile Met Xaa Asp Leu Glu Arg Ala Asn Gln Arg Ala Glu Val 
                245                 250                 255     


Ala Gln Arg Glu Ala Glu Xaa Leu Arg Glu Gln Leu Ser Ser Ala Asn 
            260                 265                 270         


His Ser Leu Gln Leu Ala Ser Gln Ile Gln Lys Ala Pro Asp Val Ala 
        275                 280                 285             


Ile Glu Val Leu Xaa Arg Ser Ser Leu Glu Val Glu Leu Ala Ala Lys 
    290                 295                 300                 


Glu Arg Glu Ile Ala Gln Leu Val Glu Asp Val Gln Arg Leu Gln Ala 
305                 310                 315                 320 


Ser Leu Xaa Lys Leu Arg Glu Asn Ser Ala Ser Gln Ile Ser Gln Leu 
                325                 330                 335     


Glu Gln Gln Leu Ser Ala Lys Asn Ser Xaa Leu Lys Gln Leu Glu Glu 
            340                 345                 350         


Lys Leu Lys Gly Gln Ala Asp Tyr Glu Glu Val Lys Lys Glu Leu Asn 
        355                 360                 365             


Ile Leu Lys Ser Met Glu Phe Ala Pro Ser Glu Gly Ala Gly Xaa Gln 
    370                 375                 380                 


Asp Ala Ala Lys Pro Leu Glu Val Leu Leu Leu Glu Lys Asn Arg Ser 
385                 390                 395                 400 


Leu Gln Ser Glu Asn Ala Ala Leu Arg Ile Ser Asn Ser Asp Leu Ser 
                405                 410                 415     


Gly Arg Cys Ala Glu Leu Gln Val Arg Ile Xaa Glu Ala Val Ala Xaa 
            420                 425                 430         


Ala Xaa Glu Gln Arg Glu Leu Ile Ala Arg Leu Glu Gln Asp Leu Ser 
        435                 440                 445             


Ile Ile Gln Ser Ile Gln Arg Pro Asp Ala Glu Gly Ala Ala Glu His 
    450                 455                 460                 


Arg Leu Glu Lys Ile Pro Glu Pro Ile Lys Glu Ala Xaa Ala Leu Phe 
465                 470                 475                 480 


Tyr Gly Pro Ala Ala Pro Ala Ser Gly Ala Leu Pro Glu Gly Gln Val 
                485                 490                 495     


Asp Ser Leu Leu Ser Ile Ile Ser Ser Gln Arg Glu Arg Phe Arg Ala 
            500                 505                 510         


Arg Asn Gln Glu Leu Glu Ala Glu Asn Arg Leu Ala Gln His Xaa Leu 
        515                 520                 525             


Gln Ala Leu Gln Ser Glu Leu Asp Ser Leu Arg Ala Asp Asn Ile Lys 
    530                 535                 540                 


Leu Phe Glu Lys Ile Lys Phe Leu Gln Ser Tyr Pro Gly Arg Gly Ser 
545                 550                 555                 560 


Gly Ser Asp Asp Xaa Glu Leu Arg Tyr Ser Ser Gln Tyr Glu Glu Arg 
                565                 570                 575     


Leu Asp Pro Phe Ser Ser Phe Ser Lys Arg Glu Arg Gln Arg Lys Tyr 
            580                 585                 590         


Leu Ser Leu Ser Pro Trp Asp Lys Ala Xaa Leu Ser Met Gly Arg Leu 
        595                 600                 605             


Val Leu Ser Asn Lys Met Ala Arg Xaa Ile Gly Phe Phe Tyr Xaa Leu 
    610                 615                 620                 


Phe Leu His Cys Leu Val Phe Leu Val Leu Tyr Lys Leu Ala Trp Ser 
625                 630                 635                 640 


Glu Ser Met Glu Arg Asp Cys Ala Xaa Phe Cys Ala Lys Lys Phe Ala 
                645                 650                 655     


Asp His Leu His Lys Phe His Glu Asn Asp Asn Gly Ala Ala Ala Gly 
            660                 665                 670         


Asp Leu Trp Gln 
        675     


<210> 7351
<211> 678
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (625)..(625)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<400> 7351
Met Ala Ala Asn Val Gly Ser Met Phe Gln Tyr Trp Lys Arg Phe Asp 
1               5                   10                  15      


Leu Gln Gln Leu Gln Arg Glu Leu Asp Ala Xaa Ala Xaa Val Leu Ala 
            20                  25                  30          


Asn Arg Gln Asp Glu Ser Glu Gln Ser Arg Lys Arg Leu Ile Glu Gln 
        35                  40                  45              


Ser Arg Glu Phe Lys Lys Asn Xaa Pro Glu Asp Leu Arg Lys Gln Val 
    50                  55                  60                  


Ala Pro Leu Leu Lys Ser Phe Gln Gly Glu Ile Asp Ala Leu Ser Lys 
65                  70                  75                  80  


Arg Ser Lys Glu Ala Glu Ala Ala Phe Leu Asn Val Tyr Lys Arg Leu 
                85                  90                  95      


Ile Asp Val Pro Asp Pro Val Pro Ala Leu Asp Leu Gly Gln Gln Leu 
            100                 105                 110         


Gln Leu Lys Val Gln Arg Leu His Asp Ile Glu Xaa Glu Asn Gln Lys 
        115                 120                 125             


Leu Arg Glu Xaa Leu Glu Glu Tyr Asn Lys Glu Phe Ala Glu Val Lys 
    130                 135                 140                 


Asn Gln Glu Val Xaa Ile Lys Ala Leu Lys Glu Lys Ile Arg Glu Tyr 
145                 150                 155                 160 


Glu Gln Xaa Leu Lys Asn Gln Ala Glu Xaa Ile Ala Leu Glu Lys Glu 
                165                 170                 175     


Gln Lys Leu Gln Asn Asp Phe Ala Glu Lys Glu Arg Lys Leu Gln Glu 
            180                 185                 190         


Xaa Gln Met Ser Xaa Xaa Ser Lys Leu Glu Glu Ala Glu His Lys Val 
        195                 200                 205             


Gln Ser Leu Gln Xaa Ala Leu Glu Lys Xaa Arg Xaa Glu Leu Phe Asp 
    210                 215                 220                 


Leu Lys Xaa Lys Tyr Asp Glu Glu Xaa Xaa Ala Lys Ala Asp Glu Ile 
225                 230                 235                 240 


Glu Met Ile Met Xaa Asp Leu Glu Arg Ala Asn Gln Arg Ala Glu Val 
                245                 250                 255     


Ala Gln Arg Glu Ala Glu Xaa Leu Arg Glu Gln Leu Ser Ser Ala Asn 
            260                 265                 270         


His Ser Leu Gln Leu Ala Ser Gln Ile Gln Lys Ala Pro Asp Val Glu 
        275                 280                 285             


Gln Ala Ile Glu Val Leu Xaa Arg Ser Ser Leu Glu Val Glu Leu Ala 
    290                 295                 300                 


Ala Lys Glu Arg Glu Ile Ala Gln Leu Val Glu Asp Val Gln Arg Leu 
305                 310                 315                 320 


Gln Ala Ser Leu Xaa Lys Leu Arg Glu Asn Ser Ala Ser Gln Ile Ser 
                325                 330                 335     


Gln Leu Glu Gln Gln Leu Ser Ala Lys Asn Ser Xaa Leu Lys Gln Leu 
            340                 345                 350         


Glu Glu Lys Leu Lys Gly Gln Ala Asp Tyr Glu Glu Val Lys Lys Glu 
        355                 360                 365             


Leu Asn Ile Leu Lys Ser Met Glu Phe Ala Pro Ser Glu Gly Ala Gly 
    370                 375                 380                 


Xaa Gln Asp Ala Ala Lys Pro Leu Glu Val Leu Leu Leu Glu Lys Asn 
385                 390                 395                 400 


Arg Ser Leu Gln Ser Glu Asn Ala Ala Leu Arg Ile Ser Asn Ser Asp 
                405                 410                 415     


Leu Ser Gly Arg Cys Ala Glu Leu Gln Val Arg Ile Xaa Glu Ala Val 
            420                 425                 430         


Ala Xaa Ala Xaa Glu Gln Arg Glu Leu Ile Ala Arg Leu Glu Gln Asp 
        435                 440                 445             


Leu Ser Ile Ile Gln Ser Ile Gln Arg Pro Asp Ala Glu Gly Ala Ala 
    450                 455                 460                 


Glu His Arg Leu Glu Lys Ile Pro Glu Pro Ile Lys Glu Ala Xaa Ala 
465                 470                 475                 480 


Leu Phe Tyr Gly Pro Ala Ala Pro Ala Ser Gly Ala Leu Pro Glu Gly 
                485                 490                 495     


Gln Val Asp Ser Leu Leu Ser Ile Ile Ser Ser Gln Arg Glu Arg Phe 
            500                 505                 510         


Arg Ala Arg Asn Gln Glu Leu Glu Ala Glu Asn Arg Leu Ala Gln His 
        515                 520                 525             


Xaa Leu Gln Ala Leu Gln Ser Glu Leu Asp Ser Leu Arg Ala Asp Asn 
    530                 535                 540                 


Ile Lys Leu Phe Glu Lys Ile Lys Phe Leu Gln Ser Tyr Pro Gly Arg 
545                 550                 555                 560 


Gly Ser Gly Ser Asp Asp Xaa Glu Leu Arg Tyr Ser Ser Gln Tyr Glu 
                565                 570                 575     


Glu Arg Leu Asp Pro Phe Ser Ser Phe Ser Lys Arg Glu Arg Gln Arg 
            580                 585                 590         


Lys Tyr Leu Ser Leu Ser Pro Trp Asp Lys Ala Xaa Leu Ser Met Gly 
        595                 600                 605             


Arg Leu Val Leu Ser Asn Lys Met Ala Arg Xaa Ile Gly Phe Phe Tyr 
    610                 615                 620                 


Xaa Leu Phe Leu His Cys Leu Val Phe Leu Val Leu Tyr Lys Leu Ala 
625                 630                 635                 640 


Trp Ser Glu Ser Met Glu Arg Asp Cys Ala Xaa Phe Cys Ala Lys Lys 
                645                 650                 655     


Phe Ala Asp His Leu His Lys Phe His Glu Asn Asp Asn Gly Ala Ala 
            660                 665                 670         


Ala Gly Asp Leu Trp Gln 
        675             


<210> 7352
<211> 1516
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (668)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(750)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (934)..(934)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (956)..(956)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (960)..(960)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1057)..(1057)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1060)..(1060)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1163)..(1163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1241)..(1241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1296)..(1296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1298)..(1298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1355)..(1355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1363)..(1363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1384)..(1384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1391)..(1391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1422)..(1422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1433)..(1433)
<223> Selenocysteine

<400> 7352
Met Ala Ala Asn Val Gly Ser Met Phe Gln Tyr Trp Lys Arg Phe Asp 
1               5                   10                  15      


Leu Gln Gln Leu Gln Arg Glu Leu Asp Ala Xaa Ala Xaa Val Leu Ala 
            20                  25                  30          


Asn Arg Gln Asp Glu Ser Glu Gln Ser Arg Lys Arg Leu Ile Glu Gln 
        35                  40                  45              


Ser Arg Glu Phe Lys Lys Asn Xaa Pro Glu Asp Leu Arg Lys Gln Val 
    50                  55                  60                  


Ala Pro Leu Leu Lys Ser Phe Gln Gly Glu Ile Asp Ala Leu Ser Lys 
65                  70                  75                  80  


Arg Ser Lys Glu Ala Glu Ala Ala Phe Leu Asn Val Tyr Lys Arg Leu 
                85                  90                  95      


Ile Asp Val Pro Asp Pro Val Pro Ala Leu Asp Leu Gly Gln Gln Leu 
            100                 105                 110         


Gln Leu Lys Val Gln Arg Leu His Asp Ile Glu Xaa Glu Asn Gln Lys 
        115                 120                 125             


Leu Arg Glu Xaa Leu Glu Glu Tyr Asn Lys Glu Phe Ala Glu Val Lys 
    130                 135                 140                 


Asn Gln Glu Val Xaa Ile Lys Ala Leu Lys Glu Lys Ile Arg Glu Tyr 
145                 150                 155                 160 


Glu Gln Xaa Leu Lys Asn Gln Ala Glu Xaa Ile Ala Leu Glu Lys Glu 
                165                 170                 175     


Gln Lys Leu Gln Asn Asp Phe Ala Glu Lys Glu Arg Lys Leu Gln Glu 
            180                 185                 190         


Xaa Gln Met Ser Xaa Xaa Ser Lys Leu Glu Glu Ala Glu His Lys Val 
        195                 200                 205             


Gln Ser Leu Gln Xaa Ala Leu Glu Lys Xaa Arg Xaa Glu Leu Phe Asp 
    210                 215                 220                 


Leu Lys Xaa Lys Tyr Asp Glu Glu Xaa Xaa Ala Lys Ala Asp Glu Ile 
225                 230                 235                 240 


Glu Met Ile Met Xaa Asp Leu Glu Arg Ala Asn Gln Arg Ala Glu Val 
                245                 250                 255     


Ala Gln Arg Glu Ala Glu Xaa Leu Arg Glu Gln Leu Ser Ser Ala Asn 
            260                 265                 270         


His Ser Leu Gln Leu Ala Ser Gln Ile Gln Lys Ala Pro Asp Val Glu 
        275                 280                 285             


Gln Ala Ile Glu Val Leu Xaa Arg Ser Ser Leu Glu Val Glu Leu Ala 
    290                 295                 300                 


Ala Lys Glu Arg Glu Ile Ala Gln Leu Val Glu Asp Val Gln Arg Leu 
305                 310                 315                 320 


Gln Ala Ser Leu Xaa Lys Leu Arg Glu Asn Ser Ala Ser Gln Ile Ser 
                325                 330                 335     


Gln Leu Glu Gln Gln Leu Ser Ala Lys Asn Ser Xaa Leu Lys Gln Leu 
            340                 345                 350         


Glu Glu Lys Leu Lys Gly Gln Ala Asp Tyr Glu Glu Val Lys Lys Glu 
        355                 360                 365             


Leu Asn Ile Leu Lys Ser Met Glu Phe Ala Pro Ser Glu Gly Ala Gly 
    370                 375                 380                 


Xaa Gln Asp Ala Ala Lys Pro Leu Glu Val Leu Leu Leu Glu Lys Asn 
385                 390                 395                 400 


Arg Ser Leu Gln Ser Glu Asn Ala Ala Leu Arg Ile Ser Asn Ser Asp 
                405                 410                 415     


Leu Ser Gly Ser Ala Arg Arg Lys Gly Lys Asp Gln Pro Glu Ser Arg 
            420                 425                 430         


Arg Pro Gly Ser Leu Pro Ala Pro Pro Pro Ser Gln Leu Pro Arg Asn 
        435                 440                 445             


Pro Gly Glu Gln Ala Ser Asn Xaa Asn Gly Xaa His Gln Phe Ser Pro 
    450                 455                 460                 


Ala Gly Leu Ser Gln Asp Phe Phe Ser Ser Ser Leu Ala Ser Pro Ser 
465                 470                 475                 480 


Leu Pro Leu Ala Ser Xaa Gly Lys Phe Ala Leu Asn Ser Leu Leu Gln 
                485                 490                 495     


Arg Gln Leu Met Gln Ser Phe Tyr Ser Lys Ala Met Gln Glu Ala Gly 
            500                 505                 510         


Ser Xaa Ser Met Ile Phe Ser Xaa Gly Pro Tyr Ser Xaa Asn Ser Ile 
        515                 520                 525             


Ser Ser Gln Ser Pro Leu Gln Gln Ser Pro Asp Val Asn Gly Met Ala 
    530                 535                 540                 


Pro Ser Pro Ser Gln Ser Glu Ser Ala Gly Ser Val Ser Glu Gly Glu 
545                 550                 555                 560 


Glu Met Asp Xaa Ala Glu Ile Ala Arg Gln Val Lys Glu Gln Leu Ile 
                565                 570                 575     


Lys His Asn Ile Gly Gln Arg Ile Phe Gly His Tyr Val Leu Gly Leu 
            580                 585                 590         


Ser Gln Gly Ser Val Ser Glu Ile Leu Ala Arg Pro Lys Pro Trp Asn 
        595                 600                 605             


Lys Leu Xaa Val Arg Gly Lys Glu Pro Phe His Lys Met Lys Gln Phe 
    610                 615                 620                 


Leu Ser Asp Glu Gln Asn Ile Leu Ala Leu Arg Ser Ile Gln Gly Arg 
625                 630                 635                 640 


Gln Arg Glu Asn Pro Gly Gln Ser Leu Asn Arg Leu Phe Gln Glu Val 
                645                 650                 655     


Pro Lys Arg Arg Asn Gly Ser Glu Gly Asn Ile Xaa Xaa Arg Ile Arg 
            660                 665                 670         


Ala Ser Glu Xaa Gly Ser Asp Glu Ala Ile Lys Ser Ile Leu Glu Gln 
        675                 680                 685             


Ala Lys Arg Glu Leu Gln Val Gln Lys Xaa Ala Glu Pro Ala Gln Pro 
    690                 695                 700                 


Ser Ser Ala Ser Gly Ser Gly Asn Ser Asp Asp Ala Ile Arg Ser Ile 
705                 710                 715                 720 


Leu Gln Gln Ala Arg Arg Glu Met Glu Ala Gln Gln Ala Ala Leu Asp 
                725                 730                 735     


Pro Ala Leu Lys Gln Ala Pro Leu Ser Gln Ser Asp Ile Xaa Ile Leu 
            740                 745                 750         


Xaa Pro Lys Leu Leu Ser Xaa Ser Pro Met Pro Xaa Val Ser Ser Tyr 
        755                 760                 765             


Pro Pro Leu Ala Ile Ser Leu Lys Lys Pro Ser Ala Ala Pro Glu Ala 
    770                 775                 780                 


Gly Ala Ser Ala Leu Pro Asn Pro Pro Ala Leu Lys Lys Glu Ala Gln 
785                 790                 795                 800 


Asp Ala Pro Gly Leu Asp Pro Gln Gly Ala Ala Asp Cys Ala Gln Gly 
                805                 810                 815     


Val Leu Arg Gln Val Lys Asn Glu Val Gly Arg Ser Gly Ala Trp Lys 
            820                 825                 830         


Asp His Trp Trp Ser Ala Val Gln Pro Glu Arg Arg Asn Ala Ala Ser 
        835                 840                 845             


Ser Glu Glu Ala Lys Ala Glu Glu Xaa Gly Gly Gly Lys Glu Lys Gly 
    850                 855                 860                 


Ser Gly Gly Ser Gly Gly Gly Ser Gln Pro Arg Ala Glu Arg Ser Gln 
865                 870                 875                 880 


Leu Gln Gly Pro Ser Ser Ser Glu Tyr Trp Lys Glu Trp Pro Ser Ala 
                885                 890                 895     


Glu Ser Pro Tyr Ser Gln Ser Ser Glu Leu Ser Leu Xaa Gly Ala Ser 
            900                 905                 910         


Arg Ser Glu Xaa Pro Gln Asn Ser Pro Leu Pro Ser Ser Pro Ile Val 
        915                 920                 925             


Pro Met Ser Lys Pro Xaa Lys Pro Ser Val Pro Pro Leu Xaa Pro Glu 
    930                 935                 940                 


Gln Tyr Glu Val Tyr Met Tyr Gln Glu Val Asp Xaa Ile Glu Leu Xaa 
945                 950                 955                 960 


Arg Gln Val Lys Glu Lys Leu Ala Lys Asn Gly Ile Cys Gln Arg Ile 
                965                 970                 975     


Phe Gly Glu Lys Val Leu Gly Leu Ser Gln Gly Ser Val Ser Asp Met 
            980                 985                 990         


Leu Ser Arg Pro Lys Pro Trp Ser  Lys Leu Xaa Gln Lys  Gly Arg Glu 
        995                 1000                 1005             


Pro Phe  Ile Arg Met Gln Leu  Trp Leu Asn Gly Glu  Leu Gly Gln 
    1010                 1015                 1020             


Gly Val  Leu Pro Val Gln Gly  Gln Gln Gln Gly Pro  Val Leu His 
    1025                 1030                 1035             


Ser Val  Xaa Ser Leu Gln Asp  Pro Leu Gln Gln Gly  Cys Val Ser 
    1040                 1045                 1050             


Ser Glu  Ser Xaa Pro Lys Xaa  Ser Ala Ser Cys Ser  Pro Ala Pro 
    1055                 1060                 1065             


Glu Ser  Pro Met Ser Ser Ser  Glu Ser Val Lys Ser  Leu Xaa Glu 
    1070                 1075                 1080             


Leu Val  Gln Gln Pro Cys Pro  Pro Ile Glu Ala Ser  Lys Asp Ser 
    1085                 1090                 1095             


Lys Pro  Pro Glu Pro Ser Asp  Pro Pro Ala Ser Asp  Ser Gln Pro 
    1100                 1105                 1110             


Xaa Xaa  Pro Leu Pro Leu Ser  Gly His Ser Ala Leu  Ser Ile Gln 
    1115                 1120                 1125             


Glu Leu  Val Ala Met Ser Pro  Glu Leu Asp Xaa Tyr  Gly Ile Xaa 
    1130                 1135                 1140             


Lys Arg  Val Lys Glu Val Leu  Xaa Asp Asn Asn Leu  Gly Gln Arg 
    1145                 1150                 1155             


Leu Phe  Gly Glu Xaa Ile Leu  Gly Leu Xaa Gln Gly  Ser Val Ser 
    1160                 1165                 1170             


Asp Leu  Leu Ala Arg Pro Lys  Pro Trp His Lys Leu  Ser Leu Lys 
    1175                 1180                 1185             


Gly Arg  Glu Pro Phe Val Arg  Met Gln Leu Trp Leu  Asn Asp Pro 
    1190                 1195                 1200             


Asn Asn  Val Glu Lys Leu Met  Asp Met Lys Arg Met  Glu Lys Lys 
    1205                 1210                 1215             


Ala Tyr  Met Lys Arg Arg His  Ser Ser Val Ser Asp  Ser Gln Pro 
    1220                 1225                 1230             


Cys Glu  Pro Pro Ser Val Gly  Xaa Glu Tyr Ser Gln  Gly Ala Ser 
    1235                 1240                 1245             


Pro Gln  Pro Gln His Gln Leu  Lys Lys Pro Arg Val  Val Leu Ala 
    1250                 1255                 1260             


Pro Glu  Glu Lys Glu Ala Leu  Lys Arg Ala Tyr Gln  Gln Lys Pro 
    1265                 1270                 1275             


Tyr Pro  Ser Pro Lys Xaa Ile  Glu Asp Leu Ala Xaa  Gln Leu Asn 
    1280                 1285                 1290             


Leu Lys  Xaa Ser Xaa Val Ile  Asn Trp Phe His Asn  Tyr Arg Ser 
    1295                 1300                 1305             


Arg Ile  Arg Arg Glu Leu Phe  Ile Glu Glu Ile Gln  Ala Gly Ser 
    1310                 1315                 1320             


Gln Gly  Gln Ala Gly Ala Ser  Asp Ser Pro Ser Ala  Arg Ser Gly 
    1325                 1330                 1335             


Arg Ala  Ala Pro Ser Ser Glu  Gly Asp Ser Cys Asp  Gly Val Glu 
    1340                 1345                 1350             


Ala Xaa  Glu Gly Pro Gly Ser  Ala Asp Xaa Glu Glu  Pro Lys Ser 
    1355                 1360                 1365             


Gln Gly  Glu Ala Glu Arg Glu  Glu Val Pro Arg Pro  Ala Glu Gln 
    1370                 1375                 1380             


Xaa Glu  Pro Pro Pro Ser Gly  Xaa Pro Gly Pro Asp  Asp Ala Arg 
    1385                 1390                 1395             


Asp Asp  Asp His Glu Gly Gly  Pro Val Glu Gly Pro  Gly Pro Leu 
    1400                 1405                 1410             


Pro Ser  Pro Ala Ser Ala Xaa  Ala Xaa Ala Ala Pro  Ala Ala Pro 
    1415                 1420                 1425             


Glu Asp  Ala Ala Xaa Ser Ala  Ala Ala Ala Pro Gly  Glu Gly Pro 
    1430                 1435                 1440             


Ala Ala  Pro Ser Ser Ala Pro  Pro Pro Ser Asn Ser  Ser Ser Ser 
    1445                 1450                 1455             


Ser Ala  Pro Arg Arg Pro Ser  Ser Leu Gln Ser Leu  Phe Gly Leu 
    1460                 1465                 1470             


Pro Glu  Ala Ala Gly Ala Arg  Asp Ser Arg Asp Asn  Pro Leu Arg 
    1475                 1480                 1485             


Lys Lys  Lys Ala Ala Asn Leu  Asn Ser Ile Ile His  Arg Leu Glu 
    1490                 1495                 1500             


Lys Ala  Ala Ser Arg Glu Glu  Pro Ile Glu Trp Glu  Phe 
    1505                 1510                 1515     


<210> 7353
<211> 632
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<400> 7353
Met Ala Ala Asn Val Gly Ser Met Phe Gln Tyr Trp Lys Arg Phe Asp 
1               5                   10                  15      


Leu Gln Gln Leu Gln Arg Glu Leu Asp Ala Xaa Ala Xaa Val Leu Ala 
            20                  25                  30          


Asn Arg Gln Asp Glu Ser Glu Gln Ser Arg Lys Arg Leu Ile Glu Gln 
        35                  40                  45              


Ser Arg Glu Phe Lys Lys Asn Xaa Pro Glu Asp Leu Arg Lys Gln Val 
    50                  55                  60                  


Ala Pro Leu Leu Lys Ser Phe Gln Gly Glu Ile Asp Ala Leu Ser Lys 
65                  70                  75                  80  


Arg Ser Lys Glu Ala Glu Ala Ala Phe Leu Asn Val Tyr Lys Arg Leu 
                85                  90                  95      


Ile Asp Val Pro Glu Val Xaa Ile Lys Ala Leu Lys Glu Lys Ile Arg 
            100                 105                 110         


Glu Tyr Glu Gln Xaa Leu Lys Asn Gln Ala Glu Xaa Ile Ala Leu Glu 
        115                 120                 125             


Lys Glu Gln Lys Leu Gln Asn Asp Phe Ala Glu Lys Glu Arg Lys Leu 
    130                 135                 140                 


Gln Glu Xaa Gln Met Ser Xaa Xaa Ser Lys Leu Glu Glu Ala Glu His 
145                 150                 155                 160 


Lys Val Gln Ser Leu Gln Xaa Ala Leu Glu Lys Xaa Arg Xaa Glu Leu 
                165                 170                 175     


Phe Asp Leu Lys Xaa Lys Tyr Asp Glu Glu Xaa Xaa Ala Lys Ala Asp 
            180                 185                 190         


Glu Ile Glu Met Ile Met Xaa Asp Leu Glu Arg Ala Asn Gln Arg Ala 
        195                 200                 205             


Glu Val Ala Gln Arg Glu Ala Glu Xaa Leu Arg Glu Gln Leu Ser Ser 
    210                 215                 220                 


Ala Asn His Ser Leu Gln Leu Ala Ser Gln Ile Gln Lys Ala Pro Asp 
225                 230                 235                 240 


Val Glu Gln Ala Ile Glu Val Leu Xaa Arg Ser Ser Leu Glu Val Glu 
                245                 250                 255     


Leu Ala Ala Lys Glu Arg Glu Ile Ala Gln Leu Val Glu Asp Val Gln 
            260                 265                 270         


Arg Leu Gln Ala Ser Leu Xaa Lys Leu Arg Glu Asn Ser Ala Ser Gln 
        275                 280                 285             


Ile Ser Gln Leu Glu Gln Gln Leu Ser Ala Lys Asn Ser Xaa Leu Lys 
    290                 295                 300                 


Gln Leu Glu Glu Lys Leu Lys Gly Gln Ala Asp Tyr Glu Glu Val Lys 
305                 310                 315                 320 


Lys Glu Leu Asn Ile Leu Lys Ser Met Glu Phe Ala Pro Ser Glu Gly 
                325                 330                 335     


Ala Gly Xaa Gln Asp Ala Ala Lys Pro Leu Glu Val Leu Leu Leu Glu 
            340                 345                 350         


Lys Asn Arg Ser Leu Gln Ser Glu Asn Ala Ala Leu Arg Ile Ser Asn 
        355                 360                 365             


Ser Asp Leu Ser Gly Arg Cys Ala Glu Leu Gln Val Arg Ile Xaa Glu 
    370                 375                 380                 


Ala Val Ala Xaa Ala Xaa Glu Gln Arg Glu Leu Ile Ala Arg Leu Glu 
385                 390                 395                 400 


Gln Asp Leu Ser Ile Ile Gln Ser Ile Gln Arg Pro Asp Ala Glu Gly 
                405                 410                 415     


Ala Ala Glu His Arg Leu Glu Lys Ile Pro Glu Pro Ile Lys Glu Ala 
            420                 425                 430         


Xaa Ala Leu Phe Tyr Gly Pro Ala Ala Pro Ala Ser Gly Ala Leu Pro 
        435                 440                 445             


Glu Gly Gln Val Asp Ser Leu Leu Ser Ile Ile Ser Ser Gln Arg Glu 
    450                 455                 460                 


Arg Phe Arg Ala Arg Asn Gln Glu Leu Glu Ala Glu Asn Arg Leu Ala 
465                 470                 475                 480 


Gln His Xaa Leu Gln Ala Leu Gln Ser Glu Leu Asp Ser Leu Arg Ala 
                485                 490                 495     


Asp Asn Ile Lys Leu Phe Glu Lys Ile Lys Phe Leu Gln Ser Tyr Pro 
            500                 505                 510         


Gly Arg Gly Ser Gly Ser Asp Asp Xaa Glu Leu Arg Tyr Ser Ser Gln 
        515                 520                 525             


Tyr Glu Glu Arg Leu Asp Pro Phe Ser Ser Phe Ser Lys Arg Glu Arg 
    530                 535                 540                 


Gln Arg Lys Tyr Leu Ser Leu Ser Pro Trp Asp Lys Ala Xaa Leu Ser 
545                 550                 555                 560 


Met Gly Arg Leu Val Leu Ser Asn Lys Met Ala Arg Xaa Ile Gly Phe 
                565                 570                 575     


Phe Tyr Xaa Leu Phe Leu His Cys Leu Val Phe Leu Val Leu Tyr Lys 
            580                 585                 590         


Leu Ala Trp Ser Glu Ser Met Glu Arg Asp Cys Ala Xaa Phe Cys Ala 
        595                 600                 605             


Lys Lys Phe Ala Asp His Leu His Lys Phe His Glu Asn Asp Asn Gly 
    610                 615                 620                 


Ala Ala Ala Gly Asp Leu Trp Gln 
625                 630         


<210> 7354
<211> 662
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(635)
<223> Selenocysteine

<400> 7354
Met Ala Ala Asn Val Gly Ser Met Phe Gln Tyr Trp Lys Arg Phe Asp 
1               5                   10                  15      


Leu Gln Gln Leu Gln Arg Glu Leu Asp Ala Xaa Ala Xaa Val Leu Ala 
            20                  25                  30          


Asn Arg Gln Asp Glu Ser Glu Gln Ser Arg Lys Arg Leu Ile Glu Gln 
        35                  40                  45              


Ser Arg Glu Phe Lys Lys Asn Xaa Pro Glu Ile Asp Ala Leu Ser Lys 
    50                  55                  60                  


Arg Ser Lys Glu Ala Glu Ala Ala Phe Leu Asn Val Tyr Lys Arg Leu 
65                  70                  75                  80  


Ile Asp Val Pro Asp Pro Val Pro Ala Leu Asp Leu Gly Gln Gln Leu 
                85                  90                  95      


Gln Leu Lys Val Gln Arg Leu His Asp Ile Glu Xaa Glu Asn Gln Lys 
            100                 105                 110         


Leu Arg Glu Xaa Leu Glu Glu Tyr Asn Lys Glu Phe Ala Glu Val Lys 
        115                 120                 125             


Asn Gln Glu Val Xaa Ile Lys Ala Leu Lys Glu Lys Ile Arg Glu Tyr 
    130                 135                 140                 


Glu Gln Xaa Leu Lys Asn Gln Ala Glu Xaa Ile Ala Leu Glu Lys Glu 
145                 150                 155                 160 


Gln Lys Leu Gln Asn Asp Phe Ala Glu Lys Glu Arg Lys Leu Gln Glu 
                165                 170                 175     


Xaa Gln Met Ser Xaa Xaa Ser Lys Leu Glu Glu Ala Glu His Lys Val 
            180                 185                 190         


Gln Ser Leu Gln Xaa Ala Leu Glu Lys Xaa Arg Xaa Glu Leu Phe Asp 
        195                 200                 205             


Leu Lys Xaa Lys Tyr Asp Glu Glu Xaa Xaa Ala Lys Ala Asp Glu Ile 
    210                 215                 220                 


Glu Met Ile Met Xaa Asp Leu Glu Arg Ala Asn Gln Arg Ala Glu Val 
225                 230                 235                 240 


Ala Gln Arg Glu Ala Glu Xaa Leu Arg Glu Gln Leu Ser Ser Ala Asn 
                245                 250                 255     


His Ser Leu Gln Leu Ala Ser Gln Ile Gln Lys Ala Pro Asp Val Glu 
            260                 265                 270         


Gln Ala Ile Glu Val Leu Xaa Arg Ser Ser Leu Glu Val Glu Leu Ala 
        275                 280                 285             


Ala Lys Glu Arg Glu Ile Ala Gln Leu Val Glu Asp Val Gln Arg Leu 
    290                 295                 300                 


Gln Ala Ser Leu Xaa Lys Leu Arg Glu Asn Ser Ala Ser Gln Ile Ser 
305                 310                 315                 320 


Gln Leu Glu Gln Gln Leu Ser Ala Lys Asn Ser Xaa Leu Lys Gln Leu 
                325                 330                 335     


Glu Glu Lys Leu Lys Gly Gln Ala Asp Tyr Glu Glu Val Lys Lys Glu 
            340                 345                 350         


Leu Asn Ile Leu Lys Ser Met Glu Phe Ala Pro Ser Glu Gly Ala Gly 
        355                 360                 365             


Xaa Gln Asp Ala Ala Lys Pro Leu Glu Val Leu Leu Leu Glu Lys Asn 
    370                 375                 380                 


Arg Ser Leu Gln Ser Glu Asn Ala Ala Leu Arg Ile Ser Asn Ser Asp 
385                 390                 395                 400 


Leu Ser Gly Arg Cys Ala Glu Leu Gln Val Arg Ile Xaa Glu Ala Val 
                405                 410                 415     


Ala Xaa Ala Xaa Glu Gln Arg Glu Leu Ile Ala Arg Leu Glu Gln Asp 
            420                 425                 430         


Leu Ser Ile Ile Gln Ser Ile Gln Arg Pro Asp Ala Glu Gly Ala Ala 
        435                 440                 445             


Glu His Arg Leu Glu Lys Ile Pro Glu Pro Ile Lys Glu Ala Xaa Ala 
    450                 455                 460                 


Leu Phe Tyr Gly Pro Ala Ala Pro Ala Ser Gly Ala Leu Pro Glu Gly 
465                 470                 475                 480 


Gln Val Asp Ser Leu Leu Ser Ile Ile Ser Ser Gln Arg Glu Arg Phe 
                485                 490                 495     


Arg Ala Arg Asn Gln Glu Leu Glu Ala Glu Asn Arg Leu Ala Gln His 
            500                 505                 510         


Xaa Leu Gln Ala Leu Gln Ser Glu Leu Asp Ser Leu Arg Ala Asp Asn 
        515                 520                 525             


Ile Lys Leu Phe Glu Lys Ile Lys Phe Leu Gln Ser Tyr Pro Gly Arg 
    530                 535                 540                 


Gly Ser Gly Ser Asp Asp Xaa Glu Leu Arg Tyr Ser Ser Gln Tyr Glu 
545                 550                 555                 560 


Glu Arg Leu Asp Pro Phe Ser Ser Phe Ser Lys Arg Glu Arg Gln Arg 
                565                 570                 575     


Lys Tyr Leu Ser Leu Ser Pro Trp Asp Lys Ala Xaa Leu Ser Met Gly 
            580                 585                 590         


Arg Leu Val Leu Ser Asn Lys Met Ala Arg Xaa Ile Gly Phe Phe Tyr 
        595                 600                 605             


Xaa Leu Phe Leu His Cys Leu Val Phe Leu Val Leu Tyr Lys Leu Ala 
    610                 615                 620                 


Trp Ser Glu Ser Met Glu Arg Asp Cys Ala Xaa Phe Cys Ala Lys Lys 
625                 630                 635                 640 


Phe Ala Asp His Leu His Lys Phe His Glu Asn Asp Asn Gly Ala Ala 
                645                 650                 655     


Ala Gly Asp Leu Trp Gln 
            660         


<210> 7355
<211> 1347
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (581)..(581)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (765)..(765)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (872)..(872)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (913)..(913)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (994)..(994)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1127)..(1127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1129)..(1129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1186)..(1186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1215)..(1215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1222)..(1222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1253)..(1253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1264)..(1264)
<223> Selenocysteine

<400> 7355
Met Leu Cys Val Ala Gly Ala Arg Leu Lys Arg Glu Leu Asp Ala Xaa 
1               5                   10                  15      


Ala Xaa Val Leu Ala Asn Arg Gln Asp Glu Ser Glu Gln Ser Arg Lys 
            20                  25                  30          


Arg Leu Ile Glu Gln Ser Arg Glu Phe Lys Lys Asn Xaa Pro Glu Asp 
        35                  40                  45              


Leu Arg Lys Gln Val Ala Pro Leu Leu Lys Ser Phe Gln Gly Glu Ile 
    50                  55                  60                  


Asp Ala Leu Ser Lys Arg Ser Lys Glu Ala Glu Ala Ala Phe Leu Asn 
65                  70                  75                  80  


Val Tyr Lys Arg Leu Ile Asp Val Pro Asp Pro Val Pro Ala Leu Asp 
                85                  90                  95      


Leu Gly Gln Gln Leu Gln Leu Lys Val Gln Arg Leu His Asp Ile Glu 
            100                 105                 110         


Xaa Glu Asn Gln Lys Leu Arg Glu Xaa Leu Glu Glu Tyr Asn Lys Glu 
        115                 120                 125             


Phe Ala Glu Val Lys Asn Gln Glu Val Xaa Ile Lys Ala Leu Lys Glu 
    130                 135                 140                 


Lys Ile Arg Glu Tyr Glu Gln Xaa Leu Lys Asn Gln Ala Glu Xaa Ile 
145                 150                 155                 160 


Ala Leu Glu Lys Glu Gln Lys Leu Gln Asn Asp Phe Ala Glu Lys Glu 
                165                 170                 175     


Arg Lys Leu Gln Glu Xaa Gln Met Ser Xaa Xaa Ser Lys Leu Glu Glu 
            180                 185                 190         


Ala Glu His Lys Val Gln Ser Leu Gln Xaa Ala Leu Glu Lys Xaa Arg 
        195                 200                 205             


Xaa Glu Leu Phe Asp Leu Lys Xaa Lys Tyr Asp Glu Glu Xaa Xaa Ala 
    210                 215                 220                 


Lys Ala Asp Glu Ile Glu Met Ile Met Xaa Asp Leu Glu Arg Ala Asn 
225                 230                 235                 240 


Gln Arg Ala Glu Val Ala Gln Arg Glu Ala Glu Xaa Leu Arg Glu Gln 
                245                 250                 255     


Leu Ser Ser Ala Asn His Ser Leu Gln Leu Ala Ser Gln Ile Gln Lys 
            260                 265                 270         


Ala Pro Asp Val Glu Gln Ala Ile Glu Val Leu Xaa Arg Ser Ser Leu 
        275                 280                 285             


Glu Val Glu Leu Ala Ala Lys Glu Arg Glu Ile Ala Gln Leu Val Glu 
    290                 295                 300                 


Asp Val Gln Arg Leu Gln Ala Ser Leu Xaa Lys Leu Arg Glu Asn Ser 
305                 310                 315                 320 


Ala Ser Gln Ile Ser Gln Leu Glu Gln Gln Leu Ser Ala Lys Asn Ser 
                325                 330                 335     


Xaa Leu Lys Gln Leu Glu Glu Lys Leu Lys Gly Gln Ala Asp Tyr Glu 
            340                 345                 350         


Glu Val Lys Lys Glu Leu Asn Ile Leu Lys Ser Met Glu Phe Ala Pro 
        355                 360                 365             


Ser Glu Gly Ala Gly Xaa Gln Asp Ala Ala Lys Pro Leu Glu Val Leu 
    370                 375                 380                 


Leu Leu Glu Lys Asn Arg Ser Leu Gln Ser Glu Asn Ala Ala Leu Arg 
385                 390                 395                 400 


Ile Ser Asn Ser Asp Leu Ser Gly Pro Tyr Ser Xaa Asn Ser Ile Ser 
                405                 410                 415     


Ser Gln Ser Pro Leu Gln Gln Ser Pro Asp Val Asn Gly Met Ala Pro 
            420                 425                 430         


Ser Pro Ser Gln Ser Glu Ser Ala Gly Ser Val Ser Glu Gly Glu Glu 
        435                 440                 445             


Met Asp Xaa Ala Glu Ile Ala Arg Gln Val Lys Glu Gln Leu Ile Lys 
    450                 455                 460                 


His Asn Ile Gly Gln Arg Ile Phe Gly His Tyr Val Leu Gly Leu Ser 
465                 470                 475                 480 


Gln Gly Ser Val Ser Glu Ile Leu Ala Arg Pro Lys Pro Trp Asn Lys 
                485                 490                 495     


Leu Xaa Val Arg Gly Lys Glu Pro Phe His Lys Met Lys Gln Phe Leu 
            500                 505                 510         


Ser Asp Glu Gln Asn Ile Leu Ala Leu Arg Ser Ile Gln Gly Arg Gln 
        515                 520                 525             


Arg Ala Glu Pro Ala Gln Pro Ser Ser Ala Ser Gly Ser Gly Asn Ser 
    530                 535                 540                 


Asp Asp Ala Ile Arg Ser Ile Leu Gln Gln Ala Arg Arg Glu Met Glu 
545                 550                 555                 560 


Ala Gln Gln Ala Ala Leu Asp Pro Ala Leu Lys Gln Ala Pro Leu Ser 
                565                 570                 575     


Gln Ser Asp Ile Xaa Ile Leu Xaa Pro Lys Leu Leu Ser Xaa Ser Pro 
            580                 585                 590         


Met Pro Xaa Val Ser Ser Tyr Pro Pro Leu Ala Ile Ser Leu Lys Lys 
        595                 600                 605             


Pro Ser Ala Ala Pro Glu Ala Gly Ala Ser Ala Leu Pro Asn Pro Pro 
    610                 615                 620                 


Ala Leu Lys Lys Glu Ala Gln Asp Ala Pro Gly Leu Asp Pro Gln Gly 
625                 630                 635                 640 


Ala Ala Asp Cys Ala Gln Gly Val Leu Arg Gln Val Lys Asn Glu Val 
                645                 650                 655     


Gly Arg Ser Gly Ala Trp Lys Asp His Trp Trp Ser Ala Val Gln Pro 
            660                 665                 670         


Glu Arg Arg Asn Ala Ala Ser Ser Glu Glu Ala Lys Ala Glu Glu Xaa 
        675                 680                 685             


Gly Gly Gly Lys Glu Lys Gly Ser Gly Gly Ser Gly Gly Gly Ser Gln 
    690                 695                 700                 


Pro Arg Ala Glu Arg Ser Gln Leu Gln Gly Pro Ser Ser Ser Glu Tyr 
705                 710                 715                 720 


Trp Lys Glu Trp Pro Ser Ala Glu Ser Pro Tyr Ser Gln Ser Ser Glu 
                725                 730                 735     


Leu Ser Leu Xaa Gly Ala Ser Arg Ser Glu Xaa Pro Gln Asn Ser Pro 
            740                 745                 750         


Leu Pro Ser Ser Pro Ile Val Pro Met Ser Lys Pro Xaa Lys Pro Ser 
        755                 760                 765             


Val Pro Pro Leu Xaa Pro Glu Gln Tyr Glu Val Tyr Met Tyr Gln Glu 
    770                 775                 780                 


Val Asp Xaa Ile Glu Leu Xaa Arg Gln Val Lys Glu Lys Leu Ala Lys 
785                 790                 795                 800 


Asn Gly Ile Cys Gln Arg Ile Phe Gly Glu Lys Val Leu Gly Leu Ser 
                805                 810                 815     


Gln Gly Ser Val Ser Asp Met Leu Ser Arg Pro Lys Pro Trp Ser Lys 
            820                 825                 830         


Leu Xaa Gln Lys Gly Arg Glu Pro Phe Ile Arg Met Gln Leu Trp Leu 
        835                 840                 845             


Asn Gly Glu Leu Gly Gln Gly Val Leu Pro Val Gln Gly Gln Gln Gln 
    850                 855                 860                 


Gly Pro Val Leu His Ser Val Xaa Ser Leu Gln Asp Pro Leu Gln Gln 
865                 870                 875                 880 


Gly Cys Val Ser Ser Glu Ser Xaa Pro Lys Xaa Ser Ala Ser Cys Ser 
                885                 890                 895     


Pro Ala Pro Glu Ser Pro Met Ser Ser Ser Glu Ser Val Lys Ser Leu 
            900                 905                 910         


Xaa Glu Leu Val Gln Gln Pro Cys Pro Pro Ile Glu Ala Ser Lys Asp 
        915                 920                 925             


Ser Lys Pro Pro Glu Pro Ser Asp Pro Pro Ala Ser Asp Ser Gln Pro 
    930                 935                 940                 


Xaa Xaa Pro Leu Pro Leu Ser Gly His Ser Ala Leu Ser Ile Gln Glu 
945                 950                 955                 960 


Leu Val Ala Met Ser Pro Glu Leu Asp Xaa Tyr Gly Ile Xaa Lys Arg 
                965                 970                 975     


Val Lys Glu Val Leu Xaa Asp Asn Asn Leu Gly Gln Arg Leu Phe Gly 
            980                 985                 990         


Glu Xaa Ile Leu Gly Leu Xaa Gln  Gly Ser Val Ser Asp  Leu Leu Ala 
        995                 1000                 1005             


Arg Pro  Lys Pro Trp His Lys  Leu Ser Leu Lys Gly  Arg Glu Pro 
    1010                 1015                 1020             


Phe Val  Arg Met Gln Leu Trp  Leu Asn Asp Pro Asn  Asn Val Glu 
    1025                 1030                 1035             


Lys Leu  Met Asp Met Lys Arg  Met Glu Lys Lys Ala  Tyr Met Lys 
    1040                 1045                 1050             


Arg Arg  His Ser Ser Val Ser  Asp Ser Gln Pro Cys  Glu Pro Pro 
    1055                 1060                 1065             


Ser Val  Gly Xaa Glu Tyr Ser  Gln Gly Ala Ser Pro  Gln Pro Gln 
    1070                 1075                 1080             


His Gln  Leu Lys Lys Pro Arg  Val Val Leu Ala Pro  Glu Glu Lys 
    1085                 1090                 1095             


Glu Ala  Leu Lys Arg Ala Tyr  Gln Gln Lys Pro Tyr  Pro Ser Pro 
    1100                 1105                 1110             


Lys Xaa  Ile Glu Asp Leu Ala  Xaa Gln Leu Asn Leu  Lys Xaa Ser 
    1115                 1120                 1125             


Xaa Val  Ile Asn Trp Phe His  Asn Tyr Arg Ser Arg  Ile Arg Arg 
    1130                 1135                 1140             


Glu Leu  Phe Ile Glu Glu Ile  Gln Ala Gly Ser Gln  Gly Gln Ala 
    1145                 1150                 1155             


Gly Ala  Ser Asp Ser Pro Ser  Ala Arg Ser Gly Arg  Ala Ala Pro 
    1160                 1165                 1170             


Ser Ser  Glu Gly Asp Ser Cys  Asp Gly Val Glu Ala  Xaa Glu Gly 
    1175                 1180                 1185             


Pro Gly  Ser Ala Asp Xaa Glu  Glu Pro Lys Ser Gln  Gly Glu Ala 
    1190                 1195                 1200             


Glu Arg  Glu Glu Val Pro Arg  Pro Ala Glu Gln Xaa  Glu Pro Pro 
    1205                 1210                 1215             


Pro Ser  Gly Xaa Pro Gly Pro  Asp Asp Ala Arg Asp  Asp Asp His 
    1220                 1225                 1230             


Glu Gly  Gly Pro Val Glu Gly  Pro Gly Pro Leu Pro  Ser Pro Ala 
    1235                 1240                 1245             


Ser Ala  Xaa Ala Xaa Ala Ala  Pro Ala Ala Pro Glu  Asp Ala Ala 
    1250                 1255                 1260             


Xaa Ser  Ala Ala Ala Ala Pro  Gly Glu Gly Pro Ala  Ala Pro Ser 
    1265                 1270                 1275             


Ser Ala  Pro Pro Pro Ser Asn  Ser Ser Ser Ser Ser  Ala Pro Arg 
    1280                 1285                 1290             


Arg Pro  Ser Ser Leu Gln Ser  Leu Phe Gly Leu Pro  Glu Ala Ala 
    1295                 1300                 1305             


Gly Ala  Arg Asp Ser Arg Asp  Asn Pro Leu Arg Lys  Lys Lys Ala 
    1310                 1315                 1320             


Ala Asn  Leu Asn Ser Ile Ile  His Arg Leu Glu Lys  Ala Ala Ser 
    1325                 1330                 1335             


Arg Glu  Glu Pro Ile Glu Trp  Glu Phe 
    1340                 1345         


<210> 7356
<211> 1403
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(640)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (829)..(829)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (843)..(843)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (847)..(847)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (969)..(969)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1001)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1026)..(1026)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1128)..(1128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1183)..(1183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1185)..(1185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1242)..(1242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1250)..(1250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1278)..(1278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1307)..(1307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1320)..(1320)
<223> Selenocysteine

<400> 7356
Met Leu Cys Val Ala Gly Ala Arg Leu Lys Arg Glu Leu Asp Ala Xaa 
1               5                   10                  15      


Ala Xaa Val Leu Ala Asn Arg Gln Asp Glu Ser Glu Gln Ser Arg Lys 
            20                  25                  30          


Arg Leu Ile Glu Gln Ser Arg Glu Phe Lys Lys Asn Xaa Pro Glu Asp 
        35                  40                  45              


Leu Arg Lys Gln Val Ala Pro Leu Leu Lys Ser Phe Gln Gly Glu Ile 
    50                  55                  60                  


Asp Ala Leu Ser Lys Arg Ser Lys Glu Ala Glu Ala Ala Phe Leu Asn 
65                  70                  75                  80  


Val Tyr Lys Arg Leu Ile Asp Val Pro Asp Pro Val Pro Ala Leu Asp 
                85                  90                  95      


Leu Gly Gln Gln Leu Gln Leu Lys Val Gln Arg Leu His Asp Ile Glu 
            100                 105                 110         


Xaa Glu Asn Gln Lys Leu Arg Glu Xaa Leu Glu Glu Tyr Asn Lys Glu 
        115                 120                 125             


Phe Ala Glu Val Lys Asn Gln Glu Val Xaa Ile Lys Ala Leu Lys Glu 
    130                 135                 140                 


Lys Ile Arg Glu Tyr Glu Gln Xaa Leu Lys Asn Gln Ala Glu Xaa Ile 
145                 150                 155                 160 


Ala Leu Glu Lys Glu Gln Lys Leu Gln Asn Asp Phe Ala Glu Lys Glu 
                165                 170                 175     


Arg Lys Leu Gln Glu Xaa Gln Met Ser Xaa Xaa Ser Lys Leu Glu Glu 
            180                 185                 190         


Ala Glu His Lys Val Gln Ser Leu Gln Xaa Ala Leu Glu Lys Xaa Arg 
        195                 200                 205             


Xaa Glu Leu Phe Asp Leu Lys Xaa Lys Tyr Asp Glu Glu Xaa Xaa Ala 
    210                 215                 220                 


Lys Ala Asp Glu Ile Glu Met Ile Met Xaa Asp Leu Glu Arg Ala Asn 
225                 230                 235                 240 


Gln Arg Ala Glu Val Ala Gln Arg Glu Ala Glu Xaa Leu Arg Glu Gln 
                245                 250                 255     


Leu Ser Ser Ala Asn His Ser Leu Gln Leu Ala Ser Gln Ile Gln Lys 
            260                 265                 270         


Ala Pro Asp Val Glu Gln Ala Ile Glu Val Leu Xaa Arg Ser Ser Leu 
        275                 280                 285             


Glu Val Glu Leu Ala Ala Lys Glu Arg Glu Ile Ala Gln Leu Val Glu 
    290                 295                 300                 


Asp Val Gln Arg Leu Gln Ala Ser Leu Xaa Lys Leu Arg Glu Asn Ser 
305                 310                 315                 320 


Ala Ser Gln Ile Ser Gln Leu Glu Gln Gln Leu Ser Ala Lys Asn Ser 
                325                 330                 335     


Xaa Leu Lys Gln Leu Glu Glu Lys Leu Lys Gly Gln Ala Asp Tyr Glu 
            340                 345                 350         


Glu Val Lys Lys Glu Leu Asn Ile Leu Lys Ser Met Glu Phe Ala Pro 
        355                 360                 365             


Ser Glu Gly Ala Gly Xaa Gln Asp Ala Ala Lys Pro Leu Glu Val Leu 
    370                 375                 380                 


Leu Leu Glu Lys Asn Arg Ser Leu Gln Ser Glu Asn Ala Ala Leu Arg 
385                 390                 395                 400 


Ile Ser Asn Ser Asp Leu Ser Gly Pro Tyr Ser Xaa Asn Ser Ile Ser 
                405                 410                 415     


Ser Gln Ser Pro Leu Gln Gln Ser Pro Asp Val Asn Gly Met Ala Pro 
            420                 425                 430         


Ser Pro Ser Gln Ser Glu Ser Ala Gly Ser Val Ser Glu Gly Glu Glu 
        435                 440                 445             


Met Asp Xaa Ala Glu Ile Ala Arg Gln Val Lys Glu Gln Leu Ile Lys 
    450                 455                 460                 


His Asn Ile Gly Gln Arg Ile Phe Gly His Tyr Val Leu Gly Leu Ser 
465                 470                 475                 480 


Gln Gly Ser Val Ser Glu Ile Leu Ala Arg Pro Lys Pro Trp Asn Lys 
                485                 490                 495     


Leu Xaa Val Arg Gly Lys Glu Pro Phe His Lys Met Lys Gln Phe Leu 
            500                 505                 510         


Ser Asp Glu Gln Asn Ile Leu Ala Leu Arg Ser Ile Gln Gly Arg Gln 
        515                 520                 525             


Arg Glu Asn Pro Gly Gln Ser Leu Asn Arg Leu Phe Gln Glu Val Pro 
    530                 535                 540                 


Lys Arg Arg Asn Gly Ser Glu Gly Asn Ile Xaa Xaa Arg Ile Arg Ala 
545                 550                 555                 560 


Ser Glu Xaa Gly Ser Asp Glu Ala Ile Lys Ser Ile Leu Glu Gln Ala 
                565                 570                 575     


Lys Arg Glu Leu Gln Val Gln Lys Xaa Ala Glu Pro Ala Gln Pro Ser 
            580                 585                 590         


Ser Ala Ser Gly Ser Gly Asn Ser Asp Asp Ala Ile Arg Ser Ile Leu 
        595                 600                 605             


Gln Gln Ala Arg Arg Glu Met Glu Ala Gln Gln Ala Ala Leu Asp Pro 
    610                 615                 620                 


Ala Leu Lys Gln Ala Pro Leu Ser Gln Ser Asp Ile Xaa Ile Leu Xaa 
625                 630                 635                 640 


Pro Lys Leu Leu Ser Xaa Ser Pro Met Pro Xaa Val Ser Ser Tyr Pro 
                645                 650                 655     


Pro Leu Ala Ile Ser Leu Lys Lys Pro Ser Ala Ala Pro Glu Ala Gly 
            660                 665                 670         


Ala Ser Ala Leu Pro Asn Pro Pro Ala Leu Lys Lys Glu Ala Gln Asp 
        675                 680                 685             


Ala Pro Gly Leu Asp Pro Gln Gly Ala Ala Asp Cys Ala Gln Gly Val 
    690                 695                 700                 


Leu Arg Gln Val Lys Asn Glu Val Gly Arg Ser Gly Ala Trp Lys Asp 
705                 710                 715                 720 


His Trp Trp Ser Ala Val Gln Pro Glu Arg Arg Asn Ala Ala Ser Ser 
                725                 730                 735     


Glu Glu Ala Lys Ala Glu Glu Xaa Gly Gly Gly Lys Glu Lys Gly Ser 
            740                 745                 750         


Gly Gly Ser Gly Gly Gly Ser Gln Pro Arg Ala Glu Arg Ser Gln Leu 
        755                 760                 765             


Gln Gly Pro Ser Ser Ser Glu Tyr Trp Lys Glu Trp Pro Ser Ala Glu 
    770                 775                 780                 


Ser Pro Tyr Ser Gln Ser Ser Glu Leu Ser Leu Xaa Gly Ala Ser Arg 
785                 790                 795                 800 


Ser Glu Xaa Pro Gln Asn Ser Pro Leu Pro Ser Ser Pro Ile Val Pro 
                805                 810                 815     


Met Ser Lys Pro Xaa Lys Pro Ser Val Pro Pro Leu Xaa Pro Glu Gln 
            820                 825                 830         


Tyr Glu Val Tyr Met Tyr Gln Glu Val Asp Xaa Ile Glu Leu Xaa Arg 
        835                 840                 845             


Gln Val Lys Glu Lys Leu Ala Lys Asn Gly Ile Cys Gln Arg Ile Phe 
    850                 855                 860                 


Gly Glu Lys Val Leu Gly Leu Ser Gln Gly Ser Val Ser Asp Met Leu 
865                 870                 875                 880 


Ser Arg Pro Lys Pro Trp Ser Lys Leu Xaa Gln Lys Gly Arg Glu Pro 
                885                 890                 895     


Phe Ile Arg Met Gln Leu Trp Leu Asn Gly Glu Leu Gly Gln Gly Val 
            900                 905                 910         


Leu Pro Val Gln Gly Gln Gln Gln Gly Pro Val Leu His Ser Val Xaa 
        915                 920                 925             


Ser Leu Gln Asp Pro Leu Gln Gln Gly Cys Val Ser Ser Glu Ser Xaa 
    930                 935                 940                 


Pro Lys Xaa Ser Ala Ser Cys Ser Pro Ala Pro Glu Ser Pro Met Ser 
945                 950                 955                 960 


Ser Ser Glu Ser Val Lys Ser Leu Xaa Glu Leu Val Gln Gln Pro Cys 
                965                 970                 975     


Pro Pro Ile Glu Ala Ser Lys Asp Ser Lys Pro Pro Glu Pro Ser Asp 
            980                 985                 990         


Pro Pro Ala Ser Asp Ser Gln Pro  Xaa Xaa Pro Leu Pro  Leu Ser Gly 
        995                 1000                 1005             


His Ser  Ala Leu Ser Ile Gln  Glu Leu Val Ala Met  Ser Pro Glu 
    1010                 1015                 1020             


Leu Asp  Xaa Tyr Gly Ile Xaa  Lys Arg Val Lys Glu  Val Leu Xaa 
    1025                 1030                 1035             


Asp Asn  Asn Leu Gly Gln Arg  Leu Phe Gly Glu Xaa  Ile Leu Gly 
    1040                 1045                 1050             


Leu Xaa  Gln Gly Ser Val Ser  Asp Leu Leu Ala Arg  Pro Lys Pro 
    1055                 1060                 1065             


Trp His  Lys Leu Ser Leu Lys  Gly Arg Glu Pro Phe  Val Arg Met 
    1070                 1075                 1080             


Gln Leu  Trp Leu Asn Asp Pro  Asn Asn Val Glu Lys  Leu Met Asp 
    1085                 1090                 1095             


Met Lys  Arg Met Glu Lys Lys  Ala Tyr Met Lys Arg  Arg His Ser 
    1100                 1105                 1110             


Ser Val  Ser Asp Ser Gln Pro  Cys Glu Pro Pro Ser  Val Gly Xaa 
    1115                 1120                 1125             


Glu Tyr  Ser Gln Gly Ala Ser  Pro Gln Pro Gln His  Gln Leu Lys 
    1130                 1135                 1140             


Lys Pro  Arg Val Val Leu Ala  Pro Glu Glu Lys Glu  Ala Leu Lys 
    1145                 1150                 1155             


Arg Ala  Tyr Gln Gln Lys Pro  Tyr Pro Ser Pro Lys  Xaa Ile Glu 
    1160                 1165                 1170             


Asp Leu  Ala Xaa Gln Leu Asn  Leu Lys Xaa Ser Xaa  Val Ile Asn 
    1175                 1180                 1185             


Trp Phe  His Asn Tyr Arg Ser  Arg Ile Arg Arg Glu  Leu Phe Ile 
    1190                 1195                 1200             


Glu Glu  Ile Gln Ala Gly Ser  Gln Gly Gln Ala Gly  Ala Ser Asp 
    1205                 1210                 1215             


Ser Pro  Ser Ala Arg Ser Gly  Arg Ala Ala Pro Ser  Ser Glu Gly 
    1220                 1225                 1230             


Asp Ser  Cys Asp Gly Val Glu  Ala Xaa Glu Gly Pro  Gly Ser Ala 
    1235                 1240                 1245             


Asp Xaa  Glu Glu Pro Lys Ser  Gln Gly Glu Ala Glu  Arg Glu Glu 
    1250                 1255                 1260             


Val Pro  Arg Pro Ala Glu Gln  Xaa Glu Pro Pro Pro  Ser Gly Xaa 
    1265                 1270                 1275             


Pro Gly  Pro Asp Asp Ala Arg  Asp Asp Asp His Glu  Gly Gly Pro 
    1280                 1285                 1290             


Val Glu  Gly Pro Gly Pro Leu  Pro Ser Pro Ala Ser  Ala Xaa Ala 
    1295                 1300                 1305             


Xaa Ala  Ala Pro Ala Ala Pro  Glu Asp Ala Ala Xaa  Ser Ala Ala 
    1310                 1315                 1320             


Ala Ala  Pro Gly Glu Gly Pro  Ala Ala Pro Ser Ser  Ala Pro Pro 
    1325                 1330                 1335             


Pro Ser  Asn Ser Ser Ser Ser  Ser Ala Pro Arg Arg  Pro Ser Ser 
    1340                 1345                 1350             


Leu Gln  Ser Leu Phe Gly Leu  Pro Glu Ala Ala Gly  Ala Arg Asp 
    1355                 1360                 1365             


Ser Arg  Asp Asn Pro Leu Arg  Lys Lys Lys Ala Ala  Asn Leu Asn 
    1370                 1375                 1380             


Ser Ile  Ile His Arg Leu Glu  Lys Ala Ala Ser Arg  Glu Glu Pro 
    1385                 1390                 1395             


Ile Glu  Trp Glu Phe 
    1400             


<210> 7357
<211> 1449
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(683)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (697)..(697)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (893)..(893)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (936)..(936)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (993)..(993)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1047)..(1048)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1076)..(1076)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1084)..(1084)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1101)..(1101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1223)..(1223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1231)..(1231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1288)..(1288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1296)..(1296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1317)..(1317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1324)..(1324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1353)..(1353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1355)..(1355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1366)..(1366)
<223> Selenocysteine

<400> 7357
Met Leu Cys Val Ala Gly Ala Arg Leu Lys Arg Glu Leu Asp Ala Xaa 
1               5                   10                  15      


Ala Xaa Val Leu Ala Asn Arg Gln Asp Glu Ser Glu Gln Ser Arg Lys 
            20                  25                  30          


Arg Leu Ile Glu Gln Ser Arg Glu Phe Lys Lys Asn Xaa Pro Glu Asp 
        35                  40                  45              


Leu Arg Lys Gln Val Ala Pro Leu Leu Lys Ser Phe Gln Gly Glu Ile 
    50                  55                  60                  


Asp Ala Leu Ser Lys Arg Ser Lys Glu Ala Glu Ala Ala Phe Leu Asn 
65                  70                  75                  80  


Val Tyr Lys Arg Leu Ile Asp Val Pro Asp Pro Val Pro Ala Leu Asp 
                85                  90                  95      


Leu Gly Gln Gln Leu Gln Leu Lys Val Gln Arg Leu His Asp Ile Glu 
            100                 105                 110         


Xaa Glu Asn Gln Lys Leu Arg Glu Xaa Leu Glu Glu Tyr Asn Lys Glu 
        115                 120                 125             


Phe Ala Glu Val Lys Asn Gln Glu Val Xaa Ile Lys Ala Leu Lys Glu 
    130                 135                 140                 


Lys Ile Arg Glu Tyr Glu Gln Xaa Leu Lys Asn Gln Ala Glu Xaa Ile 
145                 150                 155                 160 


Ala Leu Glu Lys Glu Gln Lys Leu Gln Asn Asp Phe Ala Glu Lys Glu 
                165                 170                 175     


Arg Lys Leu Gln Glu Xaa Gln Met Ser Xaa Xaa Ser Lys Leu Glu Glu 
            180                 185                 190         


Ala Glu His Lys Val Gln Ser Leu Gln Xaa Ala Leu Glu Lys Xaa Arg 
        195                 200                 205             


Xaa Glu Leu Phe Asp Leu Lys Xaa Lys Tyr Asp Glu Glu Xaa Xaa Ala 
    210                 215                 220                 


Lys Ala Asp Glu Ile Glu Met Ile Met Xaa Asp Leu Glu Arg Ala Asn 
225                 230                 235                 240 


Gln Arg Ala Glu Val Ala Gln Arg Glu Ala Glu Xaa Leu Arg Glu Gln 
                245                 250                 255     


Leu Ser Ser Ala Asn His Ser Leu Gln Leu Ala Ser Gln Ile Gln Lys 
            260                 265                 270         


Ala Pro Asp Val Glu Gln Ala Ile Glu Val Leu Xaa Arg Ser Ser Leu 
        275                 280                 285             


Glu Val Glu Leu Ala Ala Lys Glu Arg Glu Ile Ala Gln Leu Val Glu 
    290                 295                 300                 


Asp Val Gln Arg Leu Gln Ala Ser Leu Xaa Lys Leu Arg Glu Asn Ser 
305                 310                 315                 320 


Ala Ser Gln Ile Ser Gln Leu Glu Gln Gln Leu Ser Ala Lys Asn Ser 
                325                 330                 335     


Xaa Leu Lys Gln Leu Glu Glu Lys Leu Lys Gly Gln Ala Asp Tyr Glu 
            340                 345                 350         


Glu Val Lys Lys Glu Leu Asn Ile Leu Lys Ser Met Glu Phe Ala Pro 
        355                 360                 365             


Ser Glu Gly Ala Gly Xaa Gln Asp Ala Ala Lys Pro Leu Glu Val Leu 
    370                 375                 380                 


Leu Leu Glu Lys Asn Arg Ser Leu Gln Ser Glu Asn Ala Ala Leu Arg 
385                 390                 395                 400 


Ile Ser Asn Ser Asp Leu Ser Gly Ser Ala Arg Arg Lys Gly Lys Asp 
                405                 410                 415     


Gln Pro Glu Ser Arg Arg Pro Gly Ser Leu Pro Ala Pro Pro Pro Ser 
            420                 425                 430         


Gln Leu Pro Arg Asn Pro Gly Glu Gln Ala Ser Asn Xaa Asn Gly Xaa 
        435                 440                 445             


His Gln Phe Ser Pro Ala Gly Leu Ser Gln Asp Phe Phe Ser Ser Ser 
    450                 455                 460                 


Leu Ala Ser Pro Ser Leu Pro Leu Ala Ser Xaa Gly Lys Phe Ala Leu 
465                 470                 475                 480 


Asn Ser Leu Leu Gln Arg Gln Leu Met Gln Ser Phe Tyr Ser Lys Ala 
                485                 490                 495     


Met Gln Glu Ala Gly Ser Xaa Ser Met Ile Phe Ser Xaa Gly Pro Tyr 
            500                 505                 510         


Ser Xaa Asn Ser Ile Ser Ser Gln Ser Pro Leu Gln Gln Ser Pro Asp 
        515                 520                 525             


Val Asn Gly Met Ala Pro Ser Pro Ser Gln Ser Glu Ser Ala Gly Ser 
    530                 535                 540                 


Val Ser Glu Gly Glu Glu Met Asp Xaa Ala Glu Ile Ala Arg Gln Val 
545                 550                 555                 560 


Lys Glu Gln Leu Ile Lys His Asn Ile Gly Gln Arg Ile Phe Gly His 
                565                 570                 575     


Tyr Val Leu Gly Leu Ser Gln Gly Ser Val Ser Glu Ile Leu Ala Arg 
            580                 585                 590         


Pro Lys Pro Trp Asn Lys Leu Xaa Val Arg Gly Lys Glu Pro Phe His 
        595                 600                 605             


Lys Met Lys Gln Phe Leu Ser Asp Glu Gln Asn Ile Leu Ala Leu Arg 
    610                 615                 620                 


Ser Ile Gln Gly Arg Gln Arg Ala Glu Pro Ala Gln Pro Ser Ser Ala 
625                 630                 635                 640 


Ser Gly Ser Gly Asn Ser Asp Asp Ala Ile Arg Ser Ile Leu Gln Gln 
                645                 650                 655     


Ala Arg Arg Glu Met Glu Ala Gln Gln Ala Ala Leu Asp Pro Ala Leu 
            660                 665                 670         


Lys Gln Ala Pro Leu Ser Gln Ser Asp Ile Xaa Ile Leu Xaa Pro Lys 
        675                 680                 685             


Leu Leu Ser Xaa Ser Pro Met Pro Xaa Val Ser Ser Tyr Pro Pro Leu 
    690                 695                 700                 


Ala Ile Ser Leu Lys Lys Pro Ser Ala Ala Pro Glu Ala Gly Ala Ser 
705                 710                 715                 720 


Ala Leu Pro Asn Pro Pro Ala Leu Lys Lys Glu Ala Gln Asp Ala Pro 
                725                 730                 735     


Gly Leu Asp Pro Gln Gly Ala Ala Asp Cys Ala Gln Gly Val Leu Arg 
            740                 745                 750         


Gln Val Lys Asn Glu Val Gly Arg Ser Gly Ala Trp Lys Asp His Trp 
        755                 760                 765             


Trp Ser Ala Val Gln Pro Glu Arg Arg Asn Ala Ala Ser Ser Glu Glu 
    770                 775                 780                 


Ala Lys Ala Glu Glu Xaa Gly Gly Gly Lys Glu Lys Gly Ser Gly Gly 
785                 790                 795                 800 


Ser Gly Gly Gly Ser Gln Pro Arg Ala Glu Arg Ser Gln Leu Gln Gly 
                805                 810                 815     


Pro Ser Ser Ser Glu Tyr Trp Lys Glu Trp Pro Ser Ala Glu Ser Pro 
            820                 825                 830         


Tyr Ser Gln Ser Ser Glu Leu Ser Leu Xaa Gly Ala Ser Arg Ser Glu 
        835                 840                 845             


Xaa Pro Gln Asn Ser Pro Leu Pro Ser Ser Pro Ile Val Pro Met Ser 
    850                 855                 860                 


Lys Pro Xaa Lys Pro Ser Val Pro Pro Leu Xaa Pro Glu Gln Tyr Glu 
865                 870                 875                 880 


Val Tyr Met Tyr Gln Glu Val Asp Xaa Ile Glu Leu Xaa Arg Gln Val 
                885                 890                 895     


Lys Glu Lys Leu Ala Lys Asn Gly Ile Cys Gln Arg Ile Phe Gly Glu 
            900                 905                 910         


Lys Val Leu Gly Leu Ser Gln Gly Ser Val Ser Asp Met Leu Ser Arg 
        915                 920                 925             


Pro Lys Pro Trp Ser Lys Leu Xaa Gln Lys Gly Arg Glu Pro Phe Ile 
    930                 935                 940                 


Arg Met Gln Leu Trp Leu Asn Gly Glu Leu Gly Gln Gly Val Leu Pro 
945                 950                 955                 960 


Val Gln Gly Gln Gln Gln Gly Pro Val Leu His Ser Val Xaa Ser Leu 
                965                 970                 975     


Gln Asp Pro Leu Gln Gln Gly Cys Val Ser Ser Glu Ser Xaa Pro Lys 
            980                 985                 990         


Xaa Ser Ala Ser Cys Ser Pro Ala  Pro Glu Ser Pro Met  Ser Ser Ser 
        995                 1000                 1005             


Glu Ser  Val Lys Ser Leu Xaa  Glu Leu Val Gln Gln  Pro Cys Pro 
    1010                 1015                 1020             


Pro Ile  Glu Ala Ser Lys Asp  Ser Lys Pro Pro Glu  Pro Ser Asp 
    1025                 1030                 1035             


Pro Pro  Ala Ser Asp Ser Gln  Pro Xaa Xaa Pro Leu  Pro Leu Ser 
    1040                 1045                 1050             


Gly His  Ser Ala Leu Ser Ile  Gln Glu Leu Val Ala  Met Ser Pro 
    1055                 1060                 1065             


Glu Leu  Asp Xaa Tyr Gly Ile  Xaa Lys Arg Val Lys  Glu Val Leu 
    1070                 1075                 1080             


Xaa Asp  Asn Asn Leu Gly Gln  Arg Leu Phe Gly Glu  Xaa Ile Leu 
    1085                 1090                 1095             


Gly Leu  Xaa Gln Gly Ser Val  Ser Asp Leu Leu Ala  Arg Pro Lys 
    1100                 1105                 1110             


Pro Trp  His Lys Leu Ser Leu  Lys Gly Arg Glu Pro  Phe Val Arg 
    1115                 1120                 1125             


Met Gln  Leu Trp Leu Asn Asp  Pro Asn Asn Val Glu  Lys Leu Met 
    1130                 1135                 1140             


Asp Met  Lys Arg Met Glu Lys  Lys Ala Tyr Met Lys  Arg Arg His 
    1145                 1150                 1155             


Ser Ser  Val Ser Asp Ser Gln  Pro Cys Glu Pro Pro  Ser Val Gly 
    1160                 1165                 1170             


Xaa Glu  Tyr Ser Gln Gly Ala  Ser Pro Gln Pro Gln  His Gln Leu 
    1175                 1180                 1185             


Lys Lys  Pro Arg Val Val Leu  Ala Pro Glu Glu Lys  Glu Ala Leu 
    1190                 1195                 1200             


Lys Arg  Ala Tyr Gln Gln Lys  Pro Tyr Pro Ser Pro  Lys Xaa Ile 
    1205                 1210                 1215             


Glu Asp  Leu Ala Xaa Gln Leu  Asn Leu Lys Xaa Ser  Xaa Val Ile 
    1220                 1225                 1230             


Asn Trp  Phe His Asn Tyr Arg  Ser Arg Ile Arg Arg  Glu Leu Phe 
    1235                 1240                 1245             


Ile Glu  Glu Ile Gln Ala Gly  Ser Gln Gly Gln Ala  Gly Ala Ser 
    1250                 1255                 1260             


Asp Ser  Pro Ser Ala Arg Ser  Gly Arg Ala Ala Pro  Ser Ser Glu 
    1265                 1270                 1275             


Gly Asp  Ser Cys Asp Gly Val  Glu Ala Xaa Glu Gly  Pro Gly Ser 
    1280                 1285                 1290             


Ala Asp  Xaa Glu Glu Pro Lys  Ser Gln Gly Glu Ala  Glu Arg Glu 
    1295                 1300                 1305             


Glu Val  Pro Arg Pro Ala Glu  Gln Xaa Glu Pro Pro  Pro Ser Gly 
    1310                 1315                 1320             


Xaa Pro  Gly Pro Asp Asp Ala  Arg Asp Asp Asp His  Glu Gly Gly 
    1325                 1330                 1335             


Pro Val  Glu Gly Pro Gly Pro  Leu Pro Ser Pro Ala  Ser Ala Xaa 
    1340                 1345                 1350             


Ala Xaa  Ala Ala Pro Ala Ala  Pro Glu Asp Ala Ala  Xaa Ser Ala 
    1355                 1360                 1365             


Ala Ala  Ala Pro Gly Glu Gly  Pro Ala Ala Pro Ser  Ser Ala Pro 
    1370                 1375                 1380             


Pro Pro  Ser Asn Ser Ser Ser  Ser Ser Ala Pro Arg  Arg Pro Ser 
    1385                 1390                 1395             


Ser Leu  Gln Ser Leu Phe Gly  Leu Pro Glu Ala Ala  Gly Ala Arg 
    1400                 1405                 1410             


Asp Ser  Arg Asp Asn Pro Leu  Arg Lys Lys Lys Ala  Ala Asn Leu 
    1415                 1420                 1425             


Asn Ser  Ile Ile His Arg Leu  Glu Lys Ala Ala Ser  Arg Glu Glu 
    1430                 1435                 1440             


Pro Ile  Glu Trp Glu Phe 
    1445                 


<210> 7358
<211> 1483
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (635)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (883)..(883)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1106)..(1106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1110)..(1110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1118)..(1118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1130)..(1130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1208)..(1208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1263)..(1263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1322)..(1322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1330)..(1330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1351)..(1351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1387)..(1387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1400)..(1400)
<223> Selenocysteine

<400> 7358
Met Leu Cys Val Ala Gly Ala Arg Leu Lys Arg Glu Leu Asp Ala Xaa 
1               5                   10                  15      


Ala Xaa Val Leu Ala Asn Arg Gln Asp Glu Ser Glu Gln Ser Arg Lys 
            20                  25                  30          


Arg Leu Ile Glu Gln Ser Arg Glu Phe Lys Lys Asn Xaa Pro Glu Asp 
        35                  40                  45              


Leu Arg Lys Gln Val Ala Pro Leu Leu Lys Ser Phe Gln Gly Glu Ile 
    50                  55                  60                  


Asp Ala Leu Ser Lys Arg Ser Lys Glu Ala Glu Ala Ala Phe Leu Asn 
65                  70                  75                  80  


Val Tyr Lys Arg Leu Ile Asp Val Pro Asp Pro Val Pro Ala Leu Asp 
                85                  90                  95      


Leu Gly Gln Gln Leu Gln Leu Lys Val Gln Arg Leu His Asp Ile Glu 
            100                 105                 110         


Xaa Glu Asn Gln Lys Leu Arg Glu Xaa Leu Glu Glu Tyr Asn Lys Glu 
        115                 120                 125             


Phe Ala Glu Val Lys Asn Gln Glu Val Xaa Ile Lys Ala Leu Lys Glu 
    130                 135                 140                 


Lys Ile Arg Glu Tyr Glu Gln Xaa Leu Lys Asn Gln Ala Glu Xaa Ile 
145                 150                 155                 160 


Ala Leu Glu Lys Glu Gln Lys Leu Gln Asn Asp Phe Ala Glu Lys Glu 
                165                 170                 175     


Arg Lys Leu Gln Glu Xaa Gln Met Ser Xaa Xaa Ser Lys Leu Glu Glu 
            180                 185                 190         


Ala Glu His Lys Val Gln Ser Leu Gln Xaa Ala Leu Glu Lys Xaa Arg 
        195                 200                 205             


Xaa Glu Leu Phe Asp Leu Lys Xaa Lys Tyr Asp Glu Glu Xaa Xaa Ala 
    210                 215                 220                 


Lys Ala Asp Glu Ile Glu Met Ile Met Xaa Asp Leu Glu Arg Ala Asn 
225                 230                 235                 240 


Gln Arg Ala Glu Val Ala Gln Arg Glu Ala Glu Xaa Leu Arg Glu Gln 
                245                 250                 255     


Leu Ser Ser Ala Asn His Ser Leu Gln Leu Ala Ser Gln Ile Gln Lys 
            260                 265                 270         


Ala Pro Asp Val Glu Gln Ala Ile Glu Val Leu Xaa Arg Ser Ser Leu 
        275                 280                 285             


Glu Val Glu Leu Ala Ala Lys Glu Arg Glu Ile Ala Gln Leu Val Glu 
    290                 295                 300                 


Asp Val Gln Arg Leu Gln Ala Ser Leu Xaa Lys Leu Arg Glu Asn Ser 
305                 310                 315                 320 


Ala Ser Gln Ile Ser Gln Leu Glu Gln Gln Leu Ser Ala Lys Asn Ser 
                325                 330                 335     


Xaa Leu Lys Gln Leu Glu Glu Lys Leu Lys Gly Gln Ala Asp Tyr Glu 
            340                 345                 350         


Glu Val Lys Lys Glu Leu Asn Ile Leu Lys Ser Met Glu Phe Ala Pro 
        355                 360                 365             


Ser Glu Gly Ala Gly Xaa Gln Asp Ala Ala Lys Pro Leu Glu Val Leu 
    370                 375                 380                 


Leu Leu Glu Lys Asn Arg Ser Leu Gln Ser Glu Asn Ala Ala Leu Arg 
385                 390                 395                 400 


Ile Ser Asn Ser Asp Leu Ser Gly Ser Ala Arg Arg Lys Gly Lys Asp 
                405                 410                 415     


Gln Pro Glu Ser Arg Arg Pro Gly Ser Leu Pro Ala Pro Pro Pro Ser 
            420                 425                 430         


Gln Leu Pro Arg Asn Pro Gly Glu Gln Ala Ser Asn Xaa Asn Gly Xaa 
        435                 440                 445             


His Gln Phe Ser Pro Ala Gly Leu Ser Gln Asp Phe Phe Ser Ser Ser 
    450                 455                 460                 


Leu Ala Ser Pro Ser Leu Pro Leu Ala Ser Xaa Gly Lys Phe Ala Leu 
465                 470                 475                 480 


Asn Ser Leu Leu Gln Arg Gln Leu Met Gln Ser Phe Tyr Ser Lys Ala 
                485                 490                 495     


Met Gln Glu Ala Gly Ser Xaa Ser Met Ile Phe Ser Xaa Gly Pro Tyr 
            500                 505                 510         


Ser Xaa Asn Ser Ile Ser Ser Gln Ser Pro Leu Gln Gln Ser Pro Asp 
        515                 520                 525             


Val Asn Gly Met Ala Pro Ser Pro Ser Gln Ser Glu Ser Ala Gly Ser 
    530                 535                 540                 


Val Ser Glu Gly Glu Glu Met Asp Xaa Ala Glu Ile Ala Arg Gln Val 
545                 550                 555                 560 


Lys Glu Gln Leu Ile Lys His Asn Ile Gly Gln Arg Ile Phe Gly His 
                565                 570                 575     


Tyr Val Leu Gly Leu Ser Gln Gly Ser Val Ser Glu Ile Leu Ala Arg 
            580                 585                 590         


Pro Lys Pro Trp Asn Lys Leu Xaa Val Arg Gly Lys Glu Pro Phe His 
        595                 600                 605             


Lys Met Lys Gln Phe Leu Ser Asp Glu Gln Asn Ile Leu Ala Leu Arg 
    610                 615                 620                 


Ser Ile Gln Gly Arg Gln Arg Gly Asn Ile Xaa Xaa Arg Ile Arg Ala 
625                 630                 635                 640 


Ser Glu Xaa Gly Ser Asp Glu Ala Ile Lys Ser Ile Leu Glu Gln Ala 
                645                 650                 655     


Lys Arg Glu Leu Gln Val Gln Lys Xaa Ala Glu Pro Ala Gln Pro Ser 
            660                 665                 670         


Ser Ala Ser Gly Ser Gly Asn Ser Asp Asp Ala Ile Arg Ser Ile Leu 
        675                 680                 685             


Gln Gln Ala Arg Arg Glu Met Glu Ala Gln Gln Ala Ala Leu Asp Pro 
    690                 695                 700                 


Ala Leu Lys Gln Ala Pro Leu Ser Gln Ser Asp Ile Xaa Ile Leu Xaa 
705                 710                 715                 720 


Pro Lys Leu Leu Ser Xaa Ser Pro Met Pro Xaa Val Ser Ser Tyr Pro 
                725                 730                 735     


Pro Leu Ala Ile Ser Leu Lys Lys Pro Ser Ala Ala Pro Glu Ala Gly 
            740                 745                 750         


Ala Ser Ala Leu Pro Asn Pro Pro Ala Leu Lys Lys Glu Ala Gln Asp 
        755                 760                 765             


Ala Pro Gly Leu Asp Pro Gln Gly Ala Ala Asp Cys Ala Gln Gly Val 
    770                 775                 780                 


Leu Arg Gln Val Lys Asn Glu Val Gly Arg Ser Gly Ala Trp Lys Asp 
785                 790                 795                 800 


His Trp Trp Ser Ala Val Gln Pro Glu Arg Arg Asn Ala Ala Ser Ser 
                805                 810                 815     


Glu Glu Ala Lys Ala Glu Glu Xaa Gly Gly Gly Lys Glu Lys Gly Ser 
            820                 825                 830         


Gly Gly Ser Gly Gly Gly Ser Gln Pro Arg Ala Glu Arg Ser Gln Leu 
        835                 840                 845             


Gln Gly Pro Ser Ser Ser Glu Tyr Trp Lys Glu Trp Pro Ser Ala Glu 
    850                 855                 860                 


Ser Pro Tyr Ser Gln Ser Ser Glu Leu Ser Leu Xaa Gly Ala Ser Arg 
865                 870                 875                 880 


Ser Glu Xaa Pro Gln Asn Ser Pro Leu Pro Ser Ser Pro Ile Val Pro 
                885                 890                 895     


Met Ser Lys Pro Xaa Lys Pro Ser Val Pro Pro Leu Xaa Pro Glu Gln 
            900                 905                 910         


Tyr Glu Val Tyr Met Tyr Gln Glu Val Asp Xaa Ile Glu Leu Xaa Arg 
        915                 920                 925             


Gln Val Lys Glu Lys Leu Ala Lys Asn Gly Ile Cys Gln Arg Ile Phe 
    930                 935                 940                 


Gly Glu Lys Val Leu Gly Leu Ser Gln Gly Ser Val Ser Asp Met Leu 
945                 950                 955                 960 


Ser Arg Pro Lys Pro Trp Ser Lys Leu Xaa Gln Lys Gly Arg Glu Pro 
                965                 970                 975     


Phe Ile Arg Met Gln Leu Trp Leu Asn Gly Glu Leu Gly Gln Gly Val 
            980                 985                 990         


Leu Pro Val Gln Gly Gln Gln Gln  Gly Pro Val Leu His  Ser Val Xaa 
        995                 1000                 1005             


Ser Leu  Gln Asp Pro Leu Gln  Gln Gly Cys Val Ser  Ser Glu Ser 
    1010                 1015                 1020             


Xaa Pro  Lys Xaa Ser Ala Ser  Cys Ser Pro Ala Pro  Glu Ser Pro 
    1025                 1030                 1035             


Met Ser  Ser Ser Glu Ser Val  Lys Ser Leu Xaa Glu  Leu Val Gln 
    1040                 1045                 1050             


Gln Pro  Cys Pro Pro Ile Glu  Ala Ser Lys Asp Ser  Lys Pro Pro 
    1055                 1060                 1065             


Glu Pro  Ser Asp Pro Pro Ala  Ser Asp Ser Gln Pro  Xaa Xaa Pro 
    1070                 1075                 1080             


Leu Pro  Leu Ser Gly His Ser  Ala Leu Ser Ile Gln  Glu Leu Val 
    1085                 1090                 1095             


Ala Met  Ser Pro Glu Leu Asp  Xaa Tyr Gly Ile Xaa  Lys Arg Val 
    1100                 1105                 1110             


Lys Glu  Val Leu Xaa Asp Asn  Asn Leu Gly Gln Arg  Leu Phe Gly 
    1115                 1120                 1125             


Glu Xaa  Ile Leu Gly Leu Xaa  Gln Gly Ser Val Ser  Asp Leu Leu 
    1130                 1135                 1140             


Ala Arg  Pro Lys Pro Trp His  Lys Leu Ser Leu Lys  Gly Arg Glu 
    1145                 1150                 1155             


Pro Phe  Val Arg Met Gln Leu  Trp Leu Asn Asp Pro  Asn Asn Val 
    1160                 1165                 1170             


Glu Lys  Leu Met Asp Met Lys  Arg Met Glu Lys Lys  Ala Tyr Met 
    1175                 1180                 1185             


Lys Arg  Arg His Ser Ser Val  Ser Asp Ser Gln Pro  Cys Glu Pro 
    1190                 1195                 1200             


Pro Ser  Val Gly Xaa Glu Tyr  Ser Gln Gly Ala Ser  Pro Gln Pro 
    1205                 1210                 1215             


Gln His  Gln Leu Lys Lys Pro  Arg Val Val Leu Ala  Pro Glu Glu 
    1220                 1225                 1230             


Lys Glu  Ala Leu Lys Arg Ala  Tyr Gln Gln Lys Pro  Tyr Pro Ser 
    1235                 1240                 1245             


Pro Lys  Xaa Ile Glu Asp Leu  Ala Xaa Gln Leu Asn  Leu Lys Xaa 
    1250                 1255                 1260             


Ser Xaa  Val Ile Asn Trp Phe  His Asn Tyr Arg Ser  Arg Ile Arg 
    1265                 1270                 1275             


Arg Glu  Leu Phe Ile Glu Glu  Ile Gln Ala Gly Ser  Gln Gly Gln 
    1280                 1285                 1290             


Ala Gly  Ala Ser Asp Ser Pro  Ser Ala Arg Ser Gly  Arg Ala Ala 
    1295                 1300                 1305             


Pro Ser  Ser Glu Gly Asp Ser  Cys Asp Gly Val Glu  Ala Xaa Glu 
    1310                 1315                 1320             


Gly Pro  Gly Ser Ala Asp Xaa  Glu Glu Pro Lys Ser  Gln Gly Glu 
    1325                 1330                 1335             


Ala Glu  Arg Glu Glu Val Pro  Arg Pro Ala Glu Gln  Xaa Glu Pro 
    1340                 1345                 1350             


Pro Pro  Ser Gly Xaa Pro Gly  Pro Asp Asp Ala Arg  Asp Asp Asp 
    1355                 1360                 1365             


His Glu  Gly Gly Pro Val Glu  Gly Pro Gly Pro Leu  Pro Ser Pro 
    1370                 1375                 1380             


Ala Ser  Ala Xaa Ala Xaa Ala  Ala Pro Ala Ala Pro  Glu Asp Ala 
    1385                 1390                 1395             


Ala Xaa  Ser Ala Ala Ala Ala  Pro Gly Glu Gly Pro  Ala Ala Pro 
    1400                 1405                 1410             


Ser Ser  Ala Pro Pro Pro Ser  Asn Ser Ser Ser Ser  Ser Ala Pro 
    1415                 1420                 1425             


Arg Arg  Pro Ser Ser Leu Gln  Ser Leu Phe Gly Leu  Pro Glu Ala 
    1430                 1435                 1440             


Ala Gly  Ala Arg Asp Ser Arg  Asp Asn Pro Leu Arg  Lys Lys Lys 
    1445                 1450                 1455             


Ala Ala  Asn Leu Asn Ser Ile  Ile His Arg Leu Glu  Lys Ala Ala 
    1460                 1465                 1470             


Ser Arg  Glu Glu Pro Ile Glu  Trp Glu Phe 
    1475                 1480             


<210> 7359
<211> 1505
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(553)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(658)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (905)..(905)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (949)..(949)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1071)..(1071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1103)..(1104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1128)..(1128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1132)..(1132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1152)..(1152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1157)..(1157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1273)..(1273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1285)..(1285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1287)..(1287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1344)..(1344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1352)..(1352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1373)..(1373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1380)..(1380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1409)..(1409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1411)..(1411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1422)..(1422)
<223> Selenocysteine

<400> 7359
Met Leu Cys Val Ala Gly Ala Arg Leu Lys Arg Glu Leu Asp Ala Xaa 
1               5                   10                  15      


Ala Xaa Val Leu Ala Asn Arg Gln Asp Glu Ser Glu Gln Ser Arg Lys 
            20                  25                  30          


Arg Leu Ile Glu Gln Ser Arg Glu Phe Lys Lys Asn Xaa Pro Glu Asp 
        35                  40                  45              


Leu Arg Lys Gln Val Ala Pro Leu Leu Lys Ser Phe Gln Gly Glu Ile 
    50                  55                  60                  


Asp Ala Leu Ser Lys Arg Ser Lys Glu Ala Glu Ala Ala Phe Leu Asn 
65                  70                  75                  80  


Val Tyr Lys Arg Leu Ile Asp Val Pro Asp Pro Val Pro Ala Leu Asp 
                85                  90                  95      


Leu Gly Gln Gln Leu Gln Leu Lys Val Gln Arg Leu His Asp Ile Glu 
            100                 105                 110         


Xaa Glu Asn Gln Lys Leu Arg Glu Xaa Leu Glu Glu Tyr Asn Lys Glu 
        115                 120                 125             


Phe Ala Glu Val Lys Asn Gln Glu Val Xaa Ile Lys Ala Leu Lys Glu 
    130                 135                 140                 


Lys Ile Arg Glu Tyr Glu Gln Xaa Leu Lys Asn Gln Ala Glu Xaa Ile 
145                 150                 155                 160 


Ala Leu Glu Lys Glu Gln Lys Leu Gln Asn Asp Phe Ala Glu Lys Glu 
                165                 170                 175     


Arg Lys Leu Gln Glu Xaa Gln Met Ser Xaa Xaa Ser Lys Leu Glu Glu 
            180                 185                 190         


Ala Glu His Lys Val Gln Ser Leu Gln Xaa Ala Leu Glu Lys Xaa Arg 
        195                 200                 205             


Xaa Glu Leu Phe Asp Leu Lys Xaa Lys Tyr Asp Glu Glu Xaa Xaa Ala 
    210                 215                 220                 


Lys Ala Asp Glu Ile Glu Met Ile Met Xaa Asp Leu Glu Arg Ala Asn 
225                 230                 235                 240 


Gln Arg Ala Glu Val Ala Gln Arg Glu Ala Glu Xaa Leu Arg Glu Gln 
                245                 250                 255     


Leu Ser Ser Ala Asn His Ser Leu Gln Leu Ala Ser Gln Ile Gln Lys 
            260                 265                 270         


Ala Pro Asp Val Glu Gln Ala Ile Glu Val Leu Xaa Arg Ser Ser Leu 
        275                 280                 285             


Glu Val Glu Leu Ala Ala Lys Glu Arg Glu Ile Ala Gln Leu Val Glu 
    290                 295                 300                 


Asp Val Gln Arg Leu Gln Ala Ser Leu Xaa Lys Leu Arg Glu Asn Ser 
305                 310                 315                 320 


Ala Ser Gln Ile Ser Gln Leu Glu Gln Gln Leu Ser Ala Lys Asn Ser 
                325                 330                 335     


Xaa Leu Lys Gln Leu Glu Glu Lys Leu Lys Gly Gln Ala Asp Tyr Glu 
            340                 345                 350         


Glu Val Lys Lys Glu Leu Asn Ile Leu Lys Ser Met Glu Phe Ala Pro 
        355                 360                 365             


Ser Glu Gly Ala Gly Xaa Gln Asp Ala Ala Lys Pro Leu Glu Val Leu 
    370                 375                 380                 


Leu Leu Glu Lys Asn Arg Ser Leu Gln Ser Glu Asn Ala Ala Leu Arg 
385                 390                 395                 400 


Ile Ser Asn Ser Asp Leu Ser Gly Ser Ala Arg Arg Lys Gly Lys Asp 
                405                 410                 415     


Gln Pro Glu Ser Arg Arg Pro Gly Ser Leu Pro Ala Pro Pro Pro Ser 
            420                 425                 430         


Gln Leu Pro Arg Asn Pro Gly Glu Gln Ala Ser Asn Xaa Asn Gly Xaa 
        435                 440                 445             


His Gln Phe Ser Pro Ala Gly Leu Ser Gln Asp Phe Phe Ser Ser Ser 
    450                 455                 460                 


Leu Ala Ser Pro Ser Leu Pro Leu Ala Ser Xaa Gly Lys Phe Ala Leu 
465                 470                 475                 480 


Asn Ser Leu Leu Gln Arg Gln Leu Met Gln Ser Phe Tyr Ser Lys Ala 
                485                 490                 495     


Met Gln Glu Ala Gly Ser Xaa Ser Met Ile Phe Ser Xaa Gly Pro Tyr 
            500                 505                 510         


Ser Xaa Asn Ser Ile Ser Ser Gln Ser Pro Leu Gln Gln Ser Pro Asp 
        515                 520                 525             


Val Asn Gly Met Ala Pro Ser Pro Ser Gln Ser Glu Ser Ala Gly Ser 
    530                 535                 540                 


Val Ser Glu Gly Glu Glu Met Asp Xaa Ala Glu Ile Ala Arg Gln Val 
545                 550                 555                 560 


Lys Glu Gln Leu Ile Lys His Asn Ile Gly Gln Arg Ile Phe Gly His 
                565                 570                 575     


Tyr Val Leu Gly Leu Ser Gln Gly Ser Val Ser Glu Ile Leu Ala Arg 
            580                 585                 590         


Pro Lys Pro Trp Asn Lys Leu Xaa Val Arg Gly Lys Glu Pro Phe His 
        595                 600                 605             


Lys Met Lys Gln Phe Leu Ser Asp Glu Gln Asn Ile Leu Ala Leu Arg 
    610                 615                 620                 


Ser Ile Gln Gly Arg Gln Arg Glu Asn Pro Gly Gln Ser Leu Asn Arg 
625                 630                 635                 640 


Leu Phe Gln Glu Val Pro Lys Arg Arg Asn Gly Ser Glu Gly Asn Ile 
                645                 650                 655     


Xaa Xaa Arg Ile Arg Ala Ser Glu Xaa Gly Ser Asp Glu Ala Ile Lys 
            660                 665                 670         


Ser Ile Leu Glu Gln Ala Lys Arg Glu Leu Gln Val Gln Lys Xaa Ala 
        675                 680                 685             


Glu Pro Ala Gln Pro Ser Ser Ala Ser Gly Ser Gly Asn Ser Asp Asp 
    690                 695                 700                 


Ala Ile Arg Ser Ile Leu Gln Gln Ala Arg Arg Glu Met Glu Ala Gln 
705                 710                 715                 720 


Gln Ala Ala Leu Asp Pro Ala Leu Lys Gln Ala Pro Leu Ser Gln Ser 
                725                 730                 735     


Asp Ile Xaa Ile Leu Xaa Pro Lys Leu Leu Ser Xaa Ser Pro Met Pro 
            740                 745                 750         


Xaa Val Ser Ser Tyr Pro Pro Leu Ala Ile Ser Leu Lys Lys Pro Ser 
        755                 760                 765             


Ala Ala Pro Glu Ala Gly Ala Ser Ala Leu Pro Asn Pro Pro Ala Leu 
    770                 775                 780                 


Lys Lys Glu Ala Gln Asp Ala Pro Gly Leu Asp Pro Gln Gly Ala Ala 
785                 790                 795                 800 


Asp Cys Ala Gln Gly Val Leu Arg Gln Val Lys Asn Glu Val Gly Arg 
                805                 810                 815     


Ser Gly Ala Trp Lys Asp His Trp Trp Ser Ala Val Gln Pro Glu Arg 
            820                 825                 830         


Arg Asn Ala Ala Ser Ser Glu Glu Ala Lys Ala Glu Glu Xaa Gly Gly 
        835                 840                 845             


Gly Lys Glu Lys Gly Ser Gly Gly Ser Gly Gly Gly Ser Gln Pro Arg 
    850                 855                 860                 


Ala Glu Arg Ser Gln Leu Gln Gly Pro Ser Ser Ser Glu Tyr Trp Lys 
865                 870                 875                 880 


Glu Trp Pro Ser Ala Glu Ser Pro Tyr Ser Gln Ser Ser Glu Leu Ser 
                885                 890                 895     


Leu Xaa Gly Ala Ser Arg Ser Glu Xaa Pro Gln Asn Ser Pro Leu Pro 
            900                 905                 910         


Ser Ser Pro Ile Val Pro Met Ser Lys Pro Xaa Lys Pro Ser Val Pro 
        915                 920                 925             


Pro Leu Xaa Pro Glu Gln Tyr Glu Val Tyr Met Tyr Gln Glu Val Asp 
    930                 935                 940                 


Xaa Ile Glu Leu Xaa Arg Gln Val Lys Glu Lys Leu Ala Lys Asn Gly 
945                 950                 955                 960 


Ile Cys Gln Arg Ile Phe Gly Glu Lys Val Leu Gly Leu Ser Gln Gly 
                965                 970                 975     


Ser Val Ser Asp Met Leu Ser Arg Pro Lys Pro Trp Ser Lys Leu Xaa 
            980                 985                 990         


Gln Lys Gly Arg Glu Pro Phe Ile  Arg Met Gln Leu Trp  Leu Asn Gly 
        995                 1000                 1005             


Glu Leu  Gly Gln Gly Val Leu  Pro Val Gln Gly Gln  Gln Gln Gly 
    1010                 1015                 1020             


Pro Val  Leu His Ser Val Xaa  Ser Leu Gln Asp Pro  Leu Gln Gln 
    1025                 1030                 1035             


Gly Cys  Val Ser Ser Glu Ser  Xaa Pro Lys Xaa Ser  Ala Ser Cys 
    1040                 1045                 1050             


Ser Pro  Ala Pro Glu Ser Pro  Met Ser Ser Ser Glu  Ser Val Lys 
    1055                 1060                 1065             


Ser Leu  Xaa Glu Leu Val Gln  Gln Pro Cys Pro Pro  Ile Glu Ala 
    1070                 1075                 1080             


Ser Lys  Asp Ser Lys Pro Pro  Glu Pro Ser Asp Pro  Pro Ala Ser 
    1085                 1090                 1095             


Asp Ser  Gln Pro Xaa Xaa Pro  Leu Pro Leu Ser Gly  His Ser Ala 
    1100                 1105                 1110             


Leu Ser  Ile Gln Glu Leu Val  Ala Met Ser Pro Glu  Leu Asp Xaa 
    1115                 1120                 1125             


Tyr Gly  Ile Xaa Lys Arg Val  Lys Glu Val Leu Xaa  Asp Asn Asn 
    1130                 1135                 1140             


Leu Gly  Gln Arg Leu Phe Gly  Glu Xaa Ile Leu Gly  Leu Xaa Gln 
    1145                 1150                 1155             


Gly Ser  Val Ser Asp Leu Leu  Ala Arg Pro Lys Pro  Trp His Lys 
    1160                 1165                 1170             


Leu Ser  Leu Lys Gly Arg Glu  Pro Phe Val Arg Met  Gln Leu Trp 
    1175                 1180                 1185             


Leu Asn  Asp Pro Asn Asn Val  Glu Lys Leu Met Asp  Met Lys Arg 
    1190                 1195                 1200             


Met Glu  Lys Lys Ala Tyr Met  Lys Arg Arg His Ser  Ser Val Ser 
    1205                 1210                 1215             


Asp Ser  Gln Pro Cys Glu Pro  Pro Ser Val Gly Xaa  Glu Tyr Ser 
    1220                 1225                 1230             


Gln Gly  Ala Ser Pro Gln Pro  Gln His Gln Leu Lys  Lys Pro Arg 
    1235                 1240                 1245             


Val Val  Leu Ala Pro Glu Glu  Lys Glu Ala Leu Lys  Arg Ala Tyr 
    1250                 1255                 1260             


Gln Gln  Lys Pro Tyr Pro Ser  Pro Lys Xaa Ile Glu  Asp Leu Ala 
    1265                 1270                 1275             


Xaa Gln  Leu Asn Leu Lys Xaa  Ser Xaa Val Ile Asn  Trp Phe His 
    1280                 1285                 1290             


Asn Tyr  Arg Ser Arg Ile Arg  Arg Glu Leu Phe Ile  Glu Glu Ile 
    1295                 1300                 1305             


Gln Ala  Gly Ser Gln Gly Gln  Ala Gly Ala Ser Asp  Ser Pro Ser 
    1310                 1315                 1320             


Ala Arg  Ser Gly Arg Ala Ala  Pro Ser Ser Glu Gly  Asp Ser Cys 
    1325                 1330                 1335             


Asp Gly  Val Glu Ala Xaa Glu  Gly Pro Gly Ser Ala  Asp Xaa Glu 
    1340                 1345                 1350             


Glu Pro  Lys Ser Gln Gly Glu  Ala Glu Arg Glu Glu  Val Pro Arg 
    1355                 1360                 1365             


Pro Ala  Glu Gln Xaa Glu Pro  Pro Pro Ser Gly Xaa  Pro Gly Pro 
    1370                 1375                 1380             


Asp Asp  Ala Arg Asp Asp Asp  His Glu Gly Gly Pro  Val Glu Gly 
    1385                 1390                 1395             


Pro Gly  Pro Leu Pro Ser Pro  Ala Ser Ala Xaa Ala  Xaa Ala Ala 
    1400                 1405                 1410             


Pro Ala  Ala Pro Glu Asp Ala  Ala Xaa Ser Ala Ala  Ala Ala Pro 
    1415                 1420                 1425             


Gly Glu  Gly Pro Ala Ala Pro  Ser Ser Ala Pro Pro  Pro Ser Asn 
    1430                 1435                 1440             


Ser Ser  Ser Ser Ser Ala Pro  Arg Arg Pro Ser Ser  Leu Gln Ser 
    1445                 1450                 1455             


Leu Phe  Gly Leu Pro Glu Ala  Ala Gly Ala Arg Asp  Ser Arg Asp 
    1460                 1465                 1470             


Asn Pro  Leu Arg Lys Lys Lys  Ala Ala Asn Leu Asn  Ser Ile Ile 
    1475                 1480                 1485             


His Arg  Leu Glu Lys Ala Ala  Ser Arg Glu Glu Pro  Ile Glu Trp 
    1490                 1495                 1500             


Glu Phe  
    1505 


<210> 7360
<211> 1486
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (672)..(672)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (683)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (858)..(858)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (875)..(875)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (979)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (992)..(992)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1140)..(1140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1149)..(1149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1197)..(1197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1209)..(1209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1211)..(1211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1257)..(1257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1265)..(1265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1286)..(1286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1355)..(1355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1438)..(1438)
<223> Selenocysteine

<400> 7360
Met Ala Ala Asn Val Gly Ser Met Phe Gln Tyr Trp Lys Arg Phe Asp 
1               5                   10                  15      


Leu Arg Arg Leu Gln Lys Glu Leu Asn Ser Val Ala Ser Glu Leu Ser 
            20                  25                  30          


Ala Arg Gln Glu Glu Ser Glu His Ser His Lys His Leu Ile Glu Leu 
        35                  40                  45              


Arg Arg Glu Phe Lys Lys Asn Val Pro Glu Glu Ile Arg Glu Met Val 
    50                  55                  60                  


Ala Pro Val Leu Lys Ser Phe Gln Ala Glu Val Val Ala Leu Ser Lys 
65                  70                  75                  80  


Arg Ser Gln Glu Ala Glu Ala Ala Phe Leu Ser Val Tyr Lys Gln Leu 
                85                  90                  95      


Ile Glu Ala Pro Asp Pro Val Pro Val Phe Glu Ala Ala Arg Ser Leu 
            100                 105                 110         


Asp Asp Arg Leu Gln Pro Pro Ser Phe Asp Pro Ser Gly Gln Pro Arg 
        115                 120                 125             


Arg Asp Leu His Xaa Ser Trp Lys Arg Asn Pro Glu Leu Leu Ser Pro 
    130                 135                 140                 


Lys Glu Gln Arg Glu Gly Xaa Ser Pro Ala Gly Pro Xaa Leu Xaa Glu 
145                 150                 155                 160 


Gly Ser Arg Leu Pro Gly Ile Pro Gly Lys Ala Leu Leu Xaa Glu Xaa 
                165                 170                 175     


Leu Leu Gln Arg Asn Glu Ala Glu Lys Gln Lys Gly Leu Gln Glu Val 
            180                 185                 190         


Gln Ile Xaa Leu Ala Ala Arg Leu Gly Glu Ala Glu Glu Lys Ile Lys 
        195                 200                 205             


Val Leu His Ser Ala Leu Lys Ala Xaa Gln Ala Glu Leu Leu Glu Leu 
    210                 215                 220                 


Arg Arg Lys Tyr Asp Glu Glu Ala Ala Ser Lys Ala Asp Glu Val Gly 
225                 230                 235                 240 


Leu Ile Met Xaa Asn Leu Glu Lys Ala Asn Gln Arg Ala Glu Ala Ala 
                245                 250                 255     


Gln Arg Glu Val Glu Ser Leu Arg Glu Gln Leu Ala Ser Val Asn Ser 
            260                 265                 270         


Ser Ile Arg Leu Ala Cys Cys Ser Pro Gln Gly Pro Ser Gly Asp Lys 
        275                 280                 285             


Val Asn Phe Xaa Leu Cys Ser Gly Pro Arg Leu Glu Ala Ala Leu Ala 
    290                 295                 300                 


Ser Lys Asp Arg Glu Ile Leu Arg Leu Leu Lys Asp Val Gln His Leu 
305                 310                 315                 320 


Gln Ser Ser Leu Gln Glu Leu Glu Glu Ala Ser Ala Asn Gln Ile Ala 
                325                 330                 335     


Asp Leu Glu Arg Gln Leu Xaa Ala Lys Ser Glu Ala Ile Glu Lys Leu 
            340                 345                 350         


Glu Glu Lys Leu Gln Ala Gln Ser Asp Tyr Glu Glu Ile Lys Xaa Glu 
        355                 360                 365             


Leu Ser Ile Leu Lys Ala Met Lys Leu Ala Ser Ser Xaa Cys Ser Leu 
    370                 375                 380                 


Pro Gln Gly Met Ala Lys Pro Glu Asp Ser Leu Leu Ile Ala Lys Glu 
385                 390                 395                 400 


Ala Phe Phe Pro Xaa Gln Lys Phe Leu Leu Glu Lys Pro Ser Leu Leu 
                405                 410                 415     


Ala Ser Pro Glu Glu Asp Pro Ser Glu Asp Asp Ser Ile Lys Asp Ser 
            420                 425                 430         


Leu Gly Xaa Glu Gln Ser Tyr Pro Ser Pro Gln Gln Leu Pro Pro Pro 
        435                 440                 445             


Pro Gly Pro Glu Asp Pro Leu Ser Pro Ser Pro Gly Gln Pro Leu Leu 
    450                 455                 460                 


Gly Pro Ser Leu Gly Pro Asp Gly Xaa Arg Xaa Phe Ser Leu Ser Pro 
465                 470                 475                 480 


Phe Pro Ser Leu Ala Ser Gly Glu Arg Leu Met Met Pro Pro Ala Ala 
                485                 490                 495     


Phe Lys Gly Glu Ala Gly Gly Leu Leu Val Phe Pro Pro Ala Phe Tyr 
            500                 505                 510         


Gly Ala Lys Pro Pro Xaa Ala Pro Ala Xaa Pro Ala Pro Gly Pro Glu 
        515                 520                 525             


Pro Leu Gly Gly Pro Glu Pro Ala Asp Gly Gly Gly Gly Gly Ala Ala 
    530                 535                 540                 


Gly Pro Gly Ala Glu Glu Glu Gln Leu Asp Xaa Ala Glu Ile Ala Phe 
545                 550                 555                 560 


Gln Val Lys Glu Gln Leu Leu Lys His Asn Ile Gly Gln Arg Val Phe 
                565                 570                 575     


Gly His Tyr Val Leu Gly Leu Ser Gln Gly Ser Val Ser Glu Ile Leu 
            580                 585                 590         


Ala Arg Pro Lys Pro Trp Arg Lys Leu Xaa Val Lys Gly Lys Glu Pro 
        595                 600                 605             


Phe Ile Lys Met Lys Gln Phe Leu Ser Asp Glu Gln Asn Val Leu Ala 
    610                 615                 620                 


Leu Arg Xaa Ile Gln Val Arg Gln Arg Gly Ser Ile Xaa Pro Arg Ile 
625                 630                 635                 640 


Arg Xaa Pro Glu Xaa Gly Ser Asp Asp Ala Ile Lys Ser Ile Leu Glu 
                645                 650                 655     


Gln Ala Lys Lys Glu Ile Glu Ser Gln Lys Gly Gly Glu Pro Lys Xaa 
            660                 665                 670         


Ser Val Ala Pro Leu Ser Ile Ala Asn Gly Xaa Xaa Pro Ala Ser Xaa 
        675                 680                 685             


Ser Glu Asp Ala Ile Lys Ser Ile Leu Glu Gln Ala Arg Arg Glu Met 
    690                 695                 700                 


Gln Ala Gln Gln Gln Ala Leu Leu Glu Met Glu Val Ala Pro Arg Gly 
705                 710                 715                 720 


Arg Ser Val Pro Pro Ser Pro Pro Glu Arg Pro Ser Leu Ala Xaa Ala 
                725                 730                 735     


Ser Gln Asn Gly Ala Pro Ala Leu Val Lys Gln Glu Glu Gly Ser Gly 
            740                 745                 750         


Gly Pro Ala Gln Ala Pro Leu Pro Val Leu Ser Pro Ala Ala Phe Val 
        755                 760                 765             


Gln Ser Ile Ile Arg Lys Val Lys Ser Glu Ile Gly Asp Ala Gly Tyr 
    770                 775                 780                 


Phe Asp His His Trp Ala Ser Asp Arg Gly Leu Leu Ser Arg Pro Tyr 
785                 790                 795                 800 


Ala Ser Val Ser Pro Ser Leu Ser Ser Ser Ser Ser Ser Gly Tyr Ser 
                805                 810                 815     


Gly Gln Pro Asn Gly Arg Ala Trp Pro Arg Gly Asp Glu Ala Pro Val 
            820                 825                 830         


Pro Pro Glu Asp Glu Ala Ala Ala Gly Ala Glu Asp Glu Pro Pro Arg 
        835                 840                 845             


Xaa Gly Glu Leu Lys Ala Glu Gly Ala Xaa Ala Glu Ala Gly Ala Arg 
    850                 855                 860                 


Leu Pro Tyr Tyr Pro Ala Tyr Val Pro Arg Xaa Leu Lys Pro Xaa Val 
865                 870                 875                 880 


Pro Pro Leu Xaa Pro Glu Gln Tyr Glu Leu Tyr Met Tyr Arg Glu Val 
                885                 890                 895     


Asp Xaa Leu Glu Leu Xaa Arg Gln Val Lys Glu Lys Leu Ala Lys Asn 
            900                 905                 910         


Gly Ile Cys Gln Arg Ile Phe Gly Glu Lys Val Leu Gly Leu Ser Gln 
        915                 920                 925             


Gly Ser Val Ser Asp Met Leu Ser Arg Pro Lys Pro Trp Ser Lys Leu 
    930                 935                 940                 


Xaa Gln Lys Gly Arg Glu Pro Phe Ile Arg Met Gln Leu Trp Leu Ser 
945                 950                 955                 960 


Asp Gln Leu Gly Gln Ala Val Gly Gln Gln Pro Gly Ala Ser Gln Ala 
                965                 970                 975     


Ser Pro Xaa Glu Pro Arg Ser Ser Pro Ser Pro Pro Pro Ser Pro Xaa 
            980                 985                 990         


Glu Pro Glu Lys Ser Ser Gln Glu  Pro Leu Ser Leu Ser  Leu Glu Ser 
        995                 1000                 1005             


Ser Lys  Glu Asn Gln Gln Pro  Glu Gly Arg Ser Ser  Ser Ser Leu 
    1010                 1015                 1020             


Ser Gly  Lys Met Tyr Ser Gly  Ser Gln Ala Pro Gly  Gly Ile Gln 
    1025                 1030                 1035             


Glu Ile  Val Ala Met Ser Pro  Glu Leu Asp Xaa Tyr  Ser Ile Xaa 
    1040                 1045                 1050             


Lys Arg  Val Lys Glu Val Leu  Xaa Asp Asn Asn Leu  Gly Gln Arg 
    1055                 1060                 1065             


Leu Phe  Gly Glu Ser Ile Leu  Gly Leu Xaa Gln Gly  Ser Val Ser 
    1070                 1075                 1080             


Asp Leu  Leu Ser Arg Pro Lys  Pro Trp His Lys Leu  Ser Leu Lys 
    1085                 1090                 1095             


Gly Arg  Glu Pro Phe Val Arg  Met Gln Leu Trp Leu  Asn Asp Pro 
    1100                 1105                 1110             


His Asn  Val Glu Lys Leu Arg  Asp Met Lys Lys Leu  Glu Lys Lys 
    1115                 1120                 1125             


Ala Tyr  Leu Lys Arg Arg Tyr  Gly Leu Ile Ser Xaa  Gly Ser Asp 
    1130                 1135                 1140             


Ser Glu  Ser Pro Ala Xaa Arg  Ser Glu Cys Pro Ser  Pro Cys Leu 
    1145                 1150                 1155             


Gln Pro  Gln Asp Leu Ser Leu  Leu Gln Ile Lys Lys  Pro Arg Val 
    1160                 1165                 1170             


Val Leu  Ala Pro Glu Glu Lys  Glu Ala Leu Arg Lys  Ala Tyr Gln 
    1175                 1180                 1185             


Leu Glu  Pro Tyr Pro Ser Gln  Gln Xaa Ile Glu Leu  Leu Ser Phe 
    1190                 1195                 1200             


Gln Leu  Asn Leu Lys Xaa Asn  Xaa Val Ile Asn Trp  Phe His Asn 
    1205                 1210                 1215             


Tyr Arg  Ser Arg Met Arg Arg  Glu Met Leu Val Glu  Gly Xaa Gln 
    1220                 1225                 1230             


Asp Glu  Pro Asp Leu Asp Pro  Ser Gly Gly Pro Gly  Ile Leu Pro 
    1235                 1240                 1245             


Pro Gly  His Ser His Pro Asp  Pro Xaa Pro Gln Ser  Pro Asp Ser 
    1250                 1255                 1260             


Glu Xaa  Glu Asp Gln Lys Pro  Xaa Val Lys Glu Leu  Glu Leu Gln 
    1265                 1270                 1275             


Glu Gly  Pro Glu Glu Asn Ser  Xaa Pro Leu Xaa Xaa  Gln Asp Lys 
    1280                 1285                 1290             


Ala Gln  Val Arg Ile Lys Gln  Glu Gln Met Glu Glu  Asp Ala Glu 
    1295                 1300                 1305             


Glu Glu  Ala Gly Ser Gln Pro  Gln Asp Ser Gly Glu  Leu Asp Lys 
    1310                 1315                 1320             


Gly Gln  Gly Pro Pro Lys Glu  Glu His Pro Asp Pro  Pro Gly Asn 
    1325                 1330                 1335             


Asp Gly  Leu Pro Lys Val Ala  Pro Gly Pro Leu Leu  Pro Gly Gly 
    1340                 1345                 1350             


Ser Xaa  Pro Asp Cys Pro Ser  Leu His Pro Gln Gln  Glu Ser Glu 
    1355                 1360                 1365             


Ala Gly  Glu Arg Leu His Pro  Asp Pro Leu Ser Phe  Lys Ser Ala 
    1370                 1375                 1380             


Ser Glu  Ser Ser Arg Cys Ser  Leu Glu Val Ser Leu  Asn Ser Pro 
    1385                 1390                 1395             


Ser Ala  Ala Ser Ser Pro Gly  Leu Met Met Ser Val  Ser Pro Val 
    1400                 1405                 1410             


Pro Ser  Ser Ser Ala Pro Ile  Ser Pro Ser Pro Pro  Gly Ala Pro 
    1415                 1420                 1425             


Pro Ala  Lys Val Pro Ser Ala  Ser Pro Xaa Ala Asp  Met Ala Gly 
    1430                 1435                 1440             


Ala Leu  His Pro Ser Ala Lys  Val Asn Pro Asn Leu  Gln Arg Arg 
    1445                 1450                 1455             


His Glu  Lys Met Ala Asn Leu  Asn Asn Ile Ile Tyr  Arg Val Glu 
    1460                 1465                 1470             


Arg Ala  Ala Asn Arg Glu Glu  Ala Leu Glu Trp Glu  Phe 
    1475                 1480                 1485     


<210> 7361
<211> 251
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<400> 7361
Met Cys Ser Pro His Met Gly Glu Gln Asp Trp Xaa Cys Arg Asp Pro 
1               5                   10                  15      


Gly Trp Glu Gln Asn Leu Arg Gln Leu Arg Val Leu Trp Glu Gly Asn 
            20                  25                  30          


Gly Phe Ile Ala Ala Phe Arg Phe Tyr Phe Cys Xaa Phe Ala Phe Tyr 
        35                  40                  45              


Leu Pro Val Val Leu Leu Xaa Gly Pro Arg Ser Gly Ala Val Ser Gly 
    50                  55                  60                  


His Phe Trp Glu Pro Trp Xaa Ala Leu Glu Arg Arg Gln Glu Leu Pro 
65                  70                  75                  80  


Arg Lys Glu Leu Asn Ser Val Ala Ser Glu Leu Ser Ala Arg Gln Glu 
                85                  90                  95      


Glu Ser Glu His Ser His Lys His Leu Ile Glu Leu Arg Arg Glu Phe 
            100                 105                 110         


Lys Lys Asn Val Pro Glu Glu Ile Arg Glu Met Val Ala Pro Val Leu 
        115                 120                 125             


Lys Ser Phe Gln Ala Glu Val Val Ala Leu Ser Lys Arg Ser Gln Glu 
    130                 135                 140                 


Ala Glu Ala Ala Phe Leu Ser Val Tyr Lys Gln Leu Ile Glu Ala Pro 
145                 150                 155                 160 


Asp Pro Val Pro Val Phe Glu Ala Ala Arg Ser Leu Asp Asp Arg Leu 
                165                 170                 175     


Gln Pro Pro Ser Phe Asp Pro Ser Gly Gln Pro Arg Arg Asp Leu His 
            180                 185                 190         


Xaa Ser Trp Lys Arg Asn Pro Glu Leu Leu Ser Pro Lys Glu Gln Arg 
        195                 200                 205             


Glu Gly Xaa Ser Pro Ala Gly Pro Xaa Leu Xaa Glu Gly Ser Arg Leu 
    210                 215                 220                 


Pro Gly Ile Pro Gly Lys Ala Leu Leu Xaa Glu Xaa Leu Leu Gln Arg 
225                 230                 235                 240 


Asn Glu Ala Glu Lys Gln Lys Gly Leu Gln Glu 
                245                 250     


<210> 7362
<211> 55
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<400> 7362
Met Ala Pro Ile Ser Leu Ser Trp Leu Leu Arg Leu Ala Xaa Phe Cys 
1               5                   10                  15      


His Leu Xaa Val Leu Leu Ala Ala Trp Arg Arg Asp Ser Xaa Gly Cys 
            20                  25                  30          


Ser Val Pro Xaa Arg Arg Ser Asn Gly Ser Arg Xaa Arg Cys Ser Ile 
        35                  40                  45              


Trp Xaa Ala Arg Leu Leu Pro 
    50                  55  


<210> 7363
<211> 397
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<400> 7363
Met Ala Pro Ile Ser Leu Ser Trp Leu Leu Arg Leu Ala Xaa Phe Cys 
1               5                   10                  15      


His Leu Xaa Val Leu Leu Ala Gly Gln His His Gly Val Xaa Lys Cys 
            20                  25                  30          


Asn Ile Xaa Cys Ser Lys Met Xaa Ser Lys Ile Pro Val Ala Leu Leu 
        35                  40                  45              


Ile His Tyr Gln Gln Asn Gln Ala Ser Cys Gly Lys Arg Ala Ile Ile 
    50                  55                  60                  


Leu Glu Xaa Arg Gln His Arg Leu Phe Cys Ala Asp Pro Lys Glu Gln 
65                  70                  75                  80  


Trp Val Lys Asp Ala Met Gln His Leu Asp Arg Gln Ala Ala Ala Leu 
                85                  90                  95      


Xaa Arg Asn Gly Gly Xaa Phe Glu Lys Gln Ile Gly Glu Val Lys Pro 
            100                 105                 110         


Arg Xaa Xaa Pro Ala Ala Gly Gly Met Asp Glu Ser Val Val Leu Glu 
        115                 120                 125             


Pro Glu Ala Xaa Gly Glu Ser Ser Ser Leu Glu Pro Xaa Pro Ser Ser 
    130                 135                 140                 


Gln Glu Ala Gln Arg Ala Leu Gly Xaa Ser Pro Glu Leu Pro Xaa Gly 
145                 150                 155                 160 


Val Xaa Gly Ser Ser Gly Xaa Arg Leu Pro Pro Xaa Pro Lys Ala Gln 
                165                 170                 175     


Asp Gly Gly Pro Val Gly Xaa Glu Leu Phe Arg Val Pro Pro Val Ser 
            180                 185                 190         


Xaa Ala Ala Xaa Trp Gln Ser Ser Ala Pro His Gln Pro Gly Pro Ser 
        195                 200                 205             


Leu Trp Ala Glu Ala Lys Xaa Ser Glu Ala Pro Ser Xaa Gln Asp Pro 
    210                 215                 220                 


Ser Xaa Gln Ala Ser Xaa Ala Ser Ser Pro Ala Pro Glu Glu Asn Ala 
225                 230                 235                 240 


Pro Ser Glu Gly Gln Arg Val Trp Gly Gln Gly Gln Ser Pro Arg Pro 
                245                 250                 255     


Glu Asn Ser Leu Glu Arg Glu Glu Met Gly Pro Val Pro Ala His Xaa 
            260                 265                 270         


Asp Ala Phe Gln Asp Trp Gly Pro Gly Ser Met Ala His Val Ser Val 
        275                 280                 285             


Val Pro Val Ser Ser Glu Gly Xaa Pro Ser Arg Glu Pro Val Ala Ser 
    290                 295                 300                 


Gly Ser Trp Xaa Pro Lys Ala Glu Glu Pro Ile His Ala Xaa Met Asp 
305                 310                 315                 320 


Pro Gln Arg Leu Gly Val Leu Ile Xaa Pro Val Pro Asp Ala Gln Ala 
                325                 330                 335     


Ala Xaa Arg Arg Gln Ala Val Gly Leu Leu Ala Phe Leu Gly Leu Leu 
            340                 345                 350         


Phe Cys Leu Gly Val Ala Met Phe Xaa Tyr Gln Ser Leu Gln Gly Cys 
        355                 360                 365             


Pro Arg Lys Met Ala Gly Glu Met Ala Glu Gly Leu Arg Tyr Ile Pro 
    370                 375                 380                 


Arg Ser Cys Gly Ser Asn Ser Tyr Val Leu Val Pro Val 
385                 390                 395         


<210> 7364
<211> 403
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<400> 7364
Met Ala Pro Ile Ser Leu Ser Trp Leu Leu Arg Leu Ala Xaa Phe Cys 
1               5                   10                  15      


His Leu Xaa Val Leu Leu Ala Gly Xaa Ser Leu Asn Ser Gly Gln His 
            20                  25                  30          


His Gly Val Xaa Lys Cys Asn Ile Xaa Cys Ser Lys Met Xaa Ser Lys 
        35                  40                  45              


Ile Pro Val Ala Leu Leu Ile His Tyr Gln Gln Asn Gln Ala Ser Cys 
    50                  55                  60                  


Gly Lys Arg Ala Ile Ile Leu Glu Xaa Arg Gln His Arg Leu Phe Cys 
65                  70                  75                  80  


Ala Asp Pro Lys Glu Gln Trp Val Lys Asp Ala Met Gln His Leu Asp 
                85                  90                  95      


Arg Gln Ala Ala Ala Leu Xaa Arg Asn Gly Gly Xaa Phe Glu Lys Gln 
            100                 105                 110         


Ile Gly Glu Val Lys Pro Arg Xaa Xaa Pro Ala Ala Gly Gly Met Asp 
        115                 120                 125             


Glu Ser Val Val Leu Glu Pro Glu Ala Xaa Gly Glu Ser Ser Ser Leu 
    130                 135                 140                 


Glu Pro Xaa Pro Ser Ser Gln Glu Ala Gln Arg Ala Leu Gly Xaa Ser 
145                 150                 155                 160 


Pro Glu Leu Pro Xaa Gly Val Xaa Gly Ser Ser Gly Xaa Arg Leu Pro 
                165                 170                 175     


Pro Xaa Pro Lys Ala Gln Asp Gly Gly Pro Val Gly Xaa Glu Leu Phe 
            180                 185                 190         


Arg Val Pro Pro Val Ser Xaa Ala Ala Xaa Trp Gln Ser Ser Ala Pro 
        195                 200                 205             


His Gln Pro Gly Pro Ser Leu Trp Ala Glu Ala Lys Xaa Ser Glu Ala 
    210                 215                 220                 


Pro Ser Xaa Gln Asp Pro Ser Xaa Gln Ala Ser Xaa Ala Ser Ser Pro 
225                 230                 235                 240 


Ala Pro Glu Glu Asn Ala Pro Ser Glu Gly Gln Arg Val Trp Gly Gln 
                245                 250                 255     


Gly Gln Ser Pro Arg Pro Glu Asn Ser Leu Glu Arg Glu Glu Met Gly 
            260                 265                 270         


Pro Val Pro Ala His Xaa Asp Ala Phe Gln Asp Trp Gly Pro Gly Ser 
        275                 280                 285             


Met Ala His Val Ser Val Val Pro Val Ser Ser Glu Gly Xaa Pro Ser 
    290                 295                 300                 


Arg Glu Pro Val Ala Ser Gly Ser Trp Xaa Pro Lys Ala Glu Glu Pro 
305                 310                 315                 320 


Ile His Ala Xaa Met Asp Pro Gln Arg Leu Gly Val Leu Ile Xaa Pro 
                325                 330                 335     


Val Pro Asp Ala Gln Ala Ala Xaa Arg Arg Gln Ala Val Gly Leu Leu 
            340                 345                 350         


Ala Phe Leu Gly Leu Leu Phe Cys Leu Gly Val Ala Met Phe Xaa Tyr 
        355                 360                 365             


Gln Ser Leu Gln Gly Cys Pro Arg Lys Met Ala Gly Glu Met Ala Glu 
    370                 375                 380                 


Gly Leu Arg Tyr Ile Pro Arg Ser Cys Gly Ser Asn Ser Tyr Val Leu 
385                 390                 395                 400 


Val Pro Val 
            


<210> 7365
<211> 359
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<400> 7365
Met Xaa Ser Lys Ile Pro Val Ala Leu Leu Ile His Tyr Gln Gln Asn 
1               5                   10                  15      


Gln Ala Ser Cys Gly Lys Arg Ala Ile Ile Leu Glu Xaa Arg Gln His 
            20                  25                  30          


Arg Leu Phe Cys Ala Asp Pro Lys Glu Gln Trp Val Lys Asp Ala Met 
        35                  40                  45              


Gln His Leu Asp Arg Gln Ala Ala Ala Leu Xaa Arg Asn Gly Gly Xaa 
    50                  55                  60                  


Phe Glu Lys Gln Ile Gly Glu Val Lys Pro Arg Xaa Xaa Pro Ala Ala 
65                  70                  75                  80  


Gly Gly Met Asp Glu Ser Val Val Leu Glu Pro Glu Ala Xaa Gly Glu 
                85                  90                  95      


Ser Ser Ser Leu Glu Pro Xaa Pro Ser Ser Gln Glu Ala Gln Arg Ala 
            100                 105                 110         


Leu Gly Xaa Ser Pro Glu Leu Pro Xaa Gly Val Xaa Gly Ser Ser Gly 
        115                 120                 125             


Xaa Arg Leu Pro Pro Xaa Pro Lys Ala Gln Asp Gly Gly Pro Val Gly 
    130                 135                 140                 


Xaa Glu Leu Phe Arg Val Pro Pro Val Ser Xaa Ala Ala Xaa Trp Gln 
145                 150                 155                 160 


Ser Ser Ala Pro His Gln Pro Gly Pro Ser Leu Trp Ala Glu Ala Lys 
                165                 170                 175     


Xaa Ser Glu Ala Pro Ser Xaa Gln Asp Pro Ser Xaa Gln Ala Ser Xaa 
            180                 185                 190         


Ala Ser Ser Pro Ala Pro Glu Glu Asn Ala Pro Ser Glu Gly Gln Arg 
        195                 200                 205             


Val Trp Gly Gln Gly Gln Ser Pro Arg Pro Glu Asn Ser Leu Glu Arg 
    210                 215                 220                 


Glu Glu Met Gly Pro Val Pro Ala His Xaa Asp Ala Phe Gln Asp Trp 
225                 230                 235                 240 


Gly Pro Gly Ser Met Ala His Val Ser Val Val Pro Val Ser Ser Glu 
                245                 250                 255     


Gly Xaa Pro Ser Arg Glu Pro Val Ala Ser Gly Ser Trp Xaa Pro Lys 
            260                 265                 270         


Ala Glu Glu Pro Ile His Ala Xaa Met Asp Pro Gln Arg Leu Gly Val 
        275                 280                 285             


Leu Ile Xaa Pro Val Pro Asp Ala Gln Ala Ala Xaa Arg Arg Gln Ala 
    290                 295                 300                 


Val Gly Leu Leu Ala Phe Leu Gly Leu Leu Phe Cys Leu Gly Val Ala 
305                 310                 315                 320 


Met Phe Xaa Tyr Gln Ser Leu Gln Gly Cys Pro Arg Lys Met Ala Gly 
                325                 330                 335     


Glu Met Ala Glu Gly Leu Arg Tyr Ile Pro Arg Ser Cys Gly Ser Asn 
            340                 345                 350         


Ser Tyr Val Leu Val Pro Val 
        355                 


<210> 7366
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(106)
<223> Selenocysteine

<400> 7366
Met Asp Gln Phe Pro Glu Ser Val Xaa Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Xaa Val 
            20                  25                  30          


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Val Val Phe Ala Leu Xaa Asn Ser Lys Lys Pro Lys Ser 
    50                  55                  60                  


Val Xaa Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
65                  70                  75                  80  


Val Ala Xaa Leu Pro Phe Trp Xaa His Tyr Leu Ile Asn Glu Lys Gly 
                85                  90                  95      


Leu His Asn Ala Met Cys Lys Phe Xaa Xaa 
            100                 105     


<210> 7367
<211> 166
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<400> 7367
Met Asp Gln Phe Pro Glu Ser Val Xaa Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Xaa Val 
            20                  25                  30          


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Val Val Phe Ala Leu Xaa Asn Ser Lys Lys Pro Lys Ser 
    50                  55                  60                  


Val Xaa Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
65                  70                  75                  80  


Val Ala Xaa Leu Pro Phe Trp Xaa His Tyr Leu Ile Asn Glu Lys Gly 
                85                  90                  95      


Leu His Asn Ala Met Cys Lys Phe Xaa Xaa Ala Phe Phe Phe Ile Gly 
            100                 105                 110         


Phe Phe Gly Ser Ile Phe Phe Ile Xaa Val Ile Ser Ile Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Xaa Val Gln 
    130                 135                 140                 


His Gly Val Xaa Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
145                 150                 155                 160 


Ala Ala Pro Gln Phe Met 
                165     


<210> 7368
<211> 355
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<400> 7368
Met Asp Gln Phe Pro Glu Ser Val Xaa Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Xaa Val 
            20                  25                  30          


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Val Val Phe Ala Leu Xaa Asn Ser Lys Lys Pro Lys Ser 
    50                  55                  60                  


Val Xaa Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
65                  70                  75                  80  


Val Ala Xaa Leu Pro Phe Trp Xaa His Tyr Leu Ile Asn Glu Lys Gly 
                85                  90                  95      


Leu His Asn Ala Met Cys Lys Phe Xaa Xaa Ala Phe Phe Phe Ile Gly 
            100                 105                 110         


Phe Phe Gly Ser Ile Phe Phe Ile Xaa Val Ile Ser Ile Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Xaa Val Gln 
    130                 135                 140                 


His Gly Val Xaa Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
145                 150                 155                 160 


Ala Ala Pro Gln Phe Met Phe Xaa Lys Gln Lys Glu Asn Glu Cys Leu 
                165                 170                 175     


Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn 
            180                 185                 190         


Val Glu Xaa Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser 
        195                 200                 205             


Tyr Cys Tyr Phe Arg Ile Ile Gln Xaa Leu Phe Ser Cys Lys Asn His 
    210                 215                 220                 


Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe 
225                 230                 235                 240 


Phe Leu Phe Trp Xaa Pro Tyr Asn Val Met Ile Phe Leu Glu Xaa Leu 
                245                 250                 255     


Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
            260                 265                 270         


Leu Ala Leu Ser Val Xaa Glu Xaa Val Ala Phe Ser His Cys Cys Leu 
        275                 280                 285             


Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu 
    290                 295                 300                 


Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val 
305                 310                 315                 320 


His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser 
                325                 330                 335     


Val Leu Ser Ser Asn Phe Xaa Tyr His Xaa Ser Asp Gly Asp Ala Leu 
            340                 345                 350         


Leu Leu Leu 
        355 


<210> 7369
<211> 387
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<400> 7369
Met Arg Glu Pro Leu Glu Ala Phe Lys Leu Ala Asp Leu Asp Phe Arg 
1               5                   10                  15      


Lys Ser Ser Leu Ala Ser Gly Trp Arg Met Ala Ser Gly Ala Phe Xaa 
            20                  25                  30          


Met Asp Gln Phe Pro Glu Ser Val Xaa Glu Asn Phe Glu Tyr Asp Asp 
        35                  40                  45              


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Xaa Val 
    50                  55                  60                  


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
65                  70                  75                  80  


Asn Leu Leu Val Val Phe Ala Leu Xaa Asn Ser Lys Lys Pro Lys Ser 
                85                  90                  95      


Val Xaa Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
            100                 105                 110         


Val Ala Xaa Leu Pro Phe Trp Xaa His Tyr Leu Ile Asn Glu Lys Gly 
        115                 120                 125             


Leu His Asn Ala Met Cys Lys Phe Xaa Xaa Ala Phe Phe Phe Ile Gly 
    130                 135                 140                 


Phe Phe Gly Ser Ile Phe Phe Ile Xaa Val Ile Ser Ile Asp Arg Tyr 
145                 150                 155                 160 


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Xaa Val Gln 
                165                 170                 175     


His Gly Val Xaa Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
            180                 185                 190         


Ala Ala Pro Gln Phe Met Phe Xaa Lys Gln Lys Glu Asn Glu Cys Leu 
        195                 200                 205             


Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn 
    210                 215                 220                 


Val Glu Xaa Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser 
225                 230                 235                 240 


Tyr Cys Tyr Phe Arg Ile Ile Gln Xaa Leu Phe Ser Cys Lys Asn His 
                245                 250                 255     


Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe 
            260                 265                 270         


Phe Leu Phe Trp Xaa Pro Tyr Asn Val Met Ile Phe Leu Glu Xaa Leu 
        275                 280                 285             


Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
    290                 295                 300                 


Leu Ala Leu Ser Val Xaa Glu Xaa Val Ala Phe Ser His Cys Cys Leu 
305                 310                 315                 320 


Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu 
                325                 330                 335     


Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val 
            340                 345                 350         


His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser 
        355                 360                 365             


Val Leu Ser Ser Asn Phe Xaa Tyr His Xaa Ser Asp Gly Asp Ala Leu 
    370                 375                 380                 


Leu Leu Leu 
385         


<210> 7370
<211> 107
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<400> 7370
Met Ala Arg Ala Ala Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Gly Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Ala Xaa Glu Leu Arg Cys Gln Cys Leu Gln Xaa 
        35                  40                  45              


Leu Gln Gly Ile His Pro Lys Asn Ile Gln Ser Val Asn Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Xaa Glu Val Ile Ala Xaa Leu Lys Asn 
65                  70                  75                  80  


Gly Arg Lys Ala Cys Leu Asn Pro Ala Ser Pro Ile Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Asn Ser Asp Lys Ser Asn 
            100                 105         


<210> 7371
<211> 98
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<400> 7371
Met Asn Gln Xaa Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Xaa Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Val Pro Leu Ser Arg Xaa Val Arg Cys Xaa Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Xaa Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg 
                85                  90                  95      


Ser Pro 
        


<210> 7372
<211> 94
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<400> 7372
Met Ser Val Lys Gly Met Ala Ile Ala Leu Ala Val Ile Leu Cys Ala 
1               5                   10                  15      


Xaa Val Val Gln Gly Phe Pro Met Phe Lys Arg Gly Arg Cys Leu Cys 
            20                  25                  30          


Ile Gly Pro Gly Val Lys Ala Val Lys Val Ala Asp Ile Glu Lys Ala 
        35                  40                  45              


Ser Ile Met Tyr Pro Ser Asn Asn Cys Asp Lys Ile Glu Val Ile Ile 
    50                  55                  60                  


Xaa Leu Lys Glu Asn Lys Gly Gln Arg Cys Leu Asn Pro Lys Ser Lys 
65                  70                  75                  80  


Gln Ala Arg Leu Ile Ile Lys Lys Val Glu Arg Lys Asn Phe 
                85                  90                  


<210> 7373
<211> 89
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 7373
Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Xaa Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Xaa Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys 
                85                  


<210> 7374
<211> 119
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 7374
Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Xaa Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Xaa Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Gly Arg Arg Glu Glu Lys Val 
                85                  90                  95      


Gly Lys Lys Glu Lys Ile Gly Lys Lys Lys Arg Gln Lys Lys Arg Lys 
            100                 105                 110         


Ala Ala Gln Lys Arg Lys Asn 
        115                 


<210> 7375
<211> 93
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<400> 7375
Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Xaa Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Xaa Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Arg Phe Lys Met 
                85                  90              


<210> 7376
<211> 140
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 7376
Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Xaa Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Xaa Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Asn Leu Ile Ser Ala Ala Pro Ala 
                85                  90                  95      


Gly Lys Arg Val Ile Ala Gly Ala Arg Ala Leu His Pro Ser Pro Pro 
            100                 105                 110         


Arg Ala Cys Pro Xaa Ala Arg Ala Leu Cys Glu Ile Arg Leu Trp Pro 
        115                 120                 125             


Pro Pro Glu Trp Ser Trp Pro Ser Pro Gly Asp Val 
    130                 135                 140 


<210> 7377
<211> 103
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<400> 7377
Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Xaa Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Tyr Cys Xaa Cys Leu Ile Arg Val Ser Phe 
        35                  40                  45              


His Gly Ala Xaa Pro Leu Xaa Gln Gly Ser Trp Val Leu Tyr Ser Leu 
    50                  55                  60                  


Ser Cys Ala Gly Gly Glu Xaa Gly Leu Arg Glu Pro Gly Pro Met Val 
65                  70                  75                  80  


Ser Pro Arg Val Glu Ser His Gln Glu Gly Arg Leu Gly Val Pro Gly 
                85                  90                  95      


Pro Val Asn Leu Gly Lys Ala 
            100             


<210> 7378
<211> 109
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<400> 7378
Met Lys Phe Ile Ser Xaa Ser Leu Leu Leu Met Leu Leu Val Ser Ser 
1               5                   10                  15      


Leu Ser Pro Val Gln Gly Val Leu Glu Val Tyr Tyr Xaa Ser Leu Arg 
            20                  25                  30          


Cys Arg Cys Val Gln Glu Ser Ser Val Phe Ile Pro Arg Arg Phe Ile 
        35                  40                  45              


Asp Arg Ile Gln Ile Leu Pro Arg Gly Asn Gly Cys Pro Arg Lys Glu 
    50                  55                  60                  


Ile Ile Val Trp Lys Lys Asn Lys Ser Ile Val Cys Val Asp Pro Gln 
65                  70                  75                  80  


Ala Glu Trp Ile Gln Arg Met Met Glu Val Leu Arg Lys Arg Ser Ser 
                85                  90                  95      


Ser Xaa Leu Pro Val Pro Val Phe Lys Arg Lys Ile Pro 
            100                 105                 


<210> 7379
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 7379
Met Arg Leu Leu Ala Ala Ala Leu Leu Leu Leu Leu Leu Ala Leu Tyr 
1               5                   10                  15      


Xaa Ala Arg Val Asp Gly Ser Lys Cys Lys Cys Ser Arg Lys Gly Pro 
            20                  25                  30          


Lys Ile Arg Tyr Ser Asp Val Lys Lys Leu Glu Met Lys Pro Lys Tyr 
        35                  40                  45              


Pro His Cys Glu Glu Lys Met Val Ile Ile Xaa Xaa Lys Ser Val Ser 
    50                  55                  60                  


Arg Tyr Arg Gly Gln Glu His Cys Leu His Pro Lys Leu Gln Ser Xaa 
65                  70                  75                  80  


Lys Arg Phe Ile Lys Trp Tyr Asn Ala Trp Asn Glu Lys Arg Arg Val 
                85                  90                  95      


Tyr Glu Glu 
            


<210> 7380
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 7380
Met Ser Leu Leu Pro Arg Arg Ala Pro Pro Val Ser Met Arg Leu Leu 
1               5                   10                  15      


Ala Ala Ala Leu Leu Leu Leu Leu Leu Ala Leu Tyr Xaa Ala Arg Val 
            20                  25                  30          


Asp Gly Ser Lys Cys Lys Cys Ser Arg Lys Gly Pro Lys Ile Arg Tyr 
        35                  40                  45              


Ser Asp Val Lys Lys Leu Glu Met Lys Pro Lys Tyr Pro His Cys Glu 
    50                  55                  60                  


Glu Lys Met Val Ile Ile Xaa Xaa Lys Ser Val Ser Arg Tyr Arg Gly 
65                  70                  75                  80  


Gln Glu His Cys Leu His Pro Lys Leu Gln Ser Xaa Lys Arg Phe Ile 
                85                  90                  95      


Lys Trp Tyr Asn Ala Trp Asn Glu Lys Arg Arg Val Tyr Glu Glu 
            100                 105                 110     


<210> 7381
<211> 107
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<400> 7381
Met Ala Arg Ala Xaa Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Ser Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Pro Leu Ala Xaa Glu Leu Arg Cys Gln Cys Leu Gln Xaa 
        35                  40                  45              


Leu Gln Gly Ile His Leu Lys Asn Ile Gln Ser Val Lys Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Xaa Glu Val Ile Ala Xaa Leu Lys Asn 
65                  70                  75                  80  


Gly Gln Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Lys Asn Gly Lys Ser Asn 
            100                 105         


<210> 7382
<211> 107
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<400> 7382
Met Ala His Ala Xaa Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Ser Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Val Xaa Glu Leu Arg Cys Gln Cys Leu Gln Xaa 
        35                  40                  45              


Leu Gln Gly Ile His Leu Lys Asn Ile Gln Ser Val Asn Val Arg Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Xaa Glu Val Ile Ala Xaa Leu Lys Asn 
65                  70                  75                  80  


Gly Lys Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Gln Lys Ile 
                85                  90                  95      


Ile Glu Lys Ile Leu Asn Lys Gly Ser Xaa Asn 
            100                 105         


<210> 7383
<211> 114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(55)
<223> Selenocysteine

<400> 7383
Met Ser Leu Leu Ser Ser Arg Ala Ala Arg Val Pro Gly Pro Ser Ser 
1               5                   10                  15      


Ser Leu Cys Ala Leu Leu Val Leu Leu Leu Leu Leu Xaa Gln Pro Gly 
            20                  25                  30          


Pro Ile Ala Ser Ala Gly Pro Ala Ala Ala Val Leu Arg Glu Leu Arg 
        35                  40                  45              


Cys Val Cys Leu Gln Xaa Xaa Gln Gly Val His Pro Lys Met Ile Ser 
    50                  55                  60                  


Asn Leu Gln Val Phe Ala Ile Gly Pro Gln Cys Ser Lys Val Glu Val 
65                  70                  75                  80  


Val Ala Ser Leu Lys Asn Gly Lys Glu Ile Cys Leu Asp Pro Glu Ala 
                85                  90                  95      


Pro Phe Leu Lys Lys Val Ile Gln Lys Ile Leu Asp Gly Gly Asn Lys 
            100                 105                 110         


Glu Asn 
        


<210> 7384
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<400> 7384
Met Ser Leu Pro Ser Ser Arg Ala Ala Arg Val Pro Gly Pro Ser Gly 
1               5                   10                  15      


Ser Leu Cys Ala Leu Leu Ala Leu Leu Leu Leu Leu Xaa Pro Pro Gly 
            20                  25                  30          


Pro Leu Ala Ser Ala Gly Pro Val Ser Ala Val Leu Xaa Glu Leu Arg 
        35                  40                  45              


Cys Xaa Cys Leu Arg Val Xaa Leu Arg Val Asn Pro Lys Xaa Ile Gly 
    50                  55                  60                  


Lys Leu Gln Val Phe Pro Ala Gly Pro Gln Cys Ser Lys Val Glu Val 
65                  70                  75                  80  


Val Ala Ser Leu Lys Asn Gly Lys Gln Val Cys Leu Asp Pro Glu Ala 
                85                  90                  95      


Pro Phe Leu Lys Lys Val Ile Gln Lys Ile Leu Asp Arg Tyr Leu Ser 
            100                 105                 110         


Leu 
    


<210> 7385
<211> 114
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<400> 7385
Met Ser Leu Pro Ser Ser Arg Ala Ala Arg Val Pro Gly Pro Ser Gly 
1               5                   10                  15      


Ser Leu Cys Ala Leu Leu Ala Leu Leu Leu Leu Leu Xaa Pro Pro Gly 
            20                  25                  30          


Pro Leu Ala Ser Ala Gly Pro Val Ser Ala Val Leu Xaa Glu Leu Arg 
        35                  40                  45              


Cys Xaa Cys Leu Arg Val Xaa Leu Arg Val Asn Pro Lys Xaa Ile Gly 
    50                  55                  60                  


Lys Leu Gln Val Phe Pro Ala Gly Pro Gln Cys Ser Lys Val Glu Val 
65                  70                  75                  80  


Val Ala Ser Leu Lys Asn Gly Lys Gln Val Cys Leu Asp Pro Glu Ala 
                85                  90                  95      


Pro Phe Leu Lys Lys Val Ile Gln Lys Ile Leu Asp Ser Gly Asn Lys 
            100                 105                 110         


Lys Asn 
        


<210> 7386
<211> 95
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 7386
Met Xaa Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Xaa Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Xaa 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg 
                85                  90                  95  


<210> 7387
<211> 99
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 7387
Met Xaa Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Xaa Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Xaa 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 
                85                  90                  95      


Glu Asn Ser 
            


<210> 7388
<211> 125
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(125)
<223> Selenocysteine

<400> 7388
Met Lys Lys Ser Gly Val Leu Phe Leu Leu Gly Ile Ile Leu Leu Val 
1               5                   10                  15      


Leu Ile Gly Val Gln Gly Xaa Pro Val Val Arg Lys Gly Arg Cys Ser 
            20                  25                  30          


Cys Ile Ser Xaa Asn Gln Gly Xaa Ile His Leu Gln Ser Leu Lys Asp 
        35                  40                  45              


Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile 
    50                  55                  60                  


Ala Xaa Leu Lys Asn Gly Val Gln Xaa Cys Leu Asn Pro Asp Ser Ala 
65                  70                  75                  80  


Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys 
                85                  90                  95      


Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys 
            100                 105                 110         


Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Xaa Xaa 
        115                 120                 125 


<210> 7389
<211> 350
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<400> 7389
Met Ser Asn Ile Xaa Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn 
1               5                   10                  15      


Phe Xaa Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro Cys Met Leu 
            20                  25                  30          


Glu Xaa Glu Xaa Leu Asn Lys Tyr Val Val Ile Ile Ala Tyr Ala Leu 
        35                  40                  45              


Val Phe Leu Leu Ser Leu Leu Gly Asn Ser Leu Val Met Leu Val Ile 
    50                  55                  60                  


Leu Tyr Ser Arg Val Gly Arg Ser Val Xaa Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Leu Ala Asp Leu Leu Phe Ala Leu Xaa Leu Pro Ile Trp Ala 
                85                  90                  95      


Ala Ser Lys Val Asn Gly Trp Ile Phe Gly Xaa Phe Leu Cys Lys Val 
            100                 105                 110         


Val Ser Leu Leu Lys Glu Val Asn Phe Tyr Ser Gly Ile Leu Leu Leu 
        115                 120                 125             


Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala Ile Val His Ala Xaa Arg 
    130                 135                 140                 


Xaa Leu Xaa Gln Lys Arg His Leu Val Lys Phe Val Cys Leu Gly Cys 
145                 150                 155                 160 


Trp Gly Leu Ser Met Asn Leu Ser Leu Pro Phe Phe Leu Phe Arg Gln 
                165                 170                 175     


Ala Tyr His Pro Asn Asn Ser Ser Pro Val Cys Tyr Glu Val Leu Gly 
            180                 185                 190         


Asn Asp Xaa Ala Lys Trp Arg Met Val Leu Arg Ile Leu Pro His Xaa 
        195                 200                 205             


Phe Gly Phe Ile Val Pro Leu Phe Val Met Leu Phe Cys Tyr Gly Phe 
    210                 215                 220                 


Xaa Leu Arg Xaa Leu Phe Lys Ala His Met Gly Gln Lys His Arg Ala 
225                 230                 235                 240 


Met Arg Val Ile Phe Ala Val Val Leu Ile Phe Leu Leu Cys Trp Leu 
                245                 250                 255     


Pro Tyr Asn Leu Val Leu Leu Ala Asp Xaa Leu Met Arg Xaa Gln Val 
            260                 265                 270         


Ile Gln Glu Ser Cys Glu Arg Arg Asn Asn Ile Gly Arg Ala Leu Asp 
        275                 280                 285             


Ala Xaa Glu Ile Leu Gly Phe Leu His Ser Cys Leu Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Ile Gly Gln Asn Phe Arg His Gly Phe Leu Lys Ile Leu 
305                 310                 315                 320 


Ala Met His Gly Leu Val Ser Lys Glu Phe Leu Ala Arg His Arg Val 
                325                 330                 335     


Xaa Ser Tyr Xaa Ser Ser Ser Val Asn Val Ser Ser Asn Leu 
            340                 345                 350 


<210> 7390
<211> 15
<212> PRT
<213> Homo sapiens

<400> 7390
Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp 
1               5                   10                  15  


<210> 7391
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 7391
Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Xaa Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Xaa Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      


Phe Ala Leu Xaa Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Xaa Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             


Asn Phe Tyr Ser Gly Ile Leu Leu 
    130                 135     


<210> 7392
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 7392
Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Xaa Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Xaa Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      


Phe Ala Leu Xaa Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Xaa Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             


Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala 
    130                 135             


<210> 7393
<211> 172
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<400> 7393
Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Xaa Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Xaa Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      


Phe Ala Leu Xaa Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Xaa Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             


Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Leu Ala Ile Val His Ala Xaa Arg Xaa Leu Xaa Gln Lys Arg Tyr 
145                 150                 155                 160 


Leu Val Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu 
                165                 170         


<210> 7394
<211> 201
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<400> 7394
Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Xaa Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Xaa Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      


Phe Ala Leu Xaa Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Xaa Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             


Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Leu Ala Ile Val His Ala Xaa Arg Xaa Leu Xaa Gln Lys Arg Tyr 
145                 150                 155                 160 


Leu Val Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu 
                165                 170                 175     


Ala Leu Pro Val Leu Leu Phe Arg Arg Xaa Val Tyr Ser Ser Asn Val 
            180                 185                 190         


Ser Pro Ala Cys Tyr Glu Asp Met Gly 
        195                 200     


<210> 7395
<211> 360
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(359)
<223> Selenocysteine

<400> 7395
Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Xaa Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Xaa Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      


Phe Ala Leu Xaa Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Xaa Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             


Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Leu Ala Ile Val His Ala Xaa Arg Xaa Leu Xaa Gln Lys Arg Tyr 
145                 150                 155                 160 


Leu Val Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu 
                165                 170                 175     


Ala Leu Pro Val Leu Leu Phe Arg Arg Xaa Val Tyr Ser Ser Asn Val 
            180                 185                 190         


Ser Pro Ala Cys Tyr Glu Asp Met Gly Asn Asn Xaa Ala Asn Trp Arg 
        195                 200                 205             


Met Leu Leu Arg Ile Leu Pro Gln Ser Phe Gly Phe Ile Val Pro Leu 
    210                 215                 220                 


Leu Ile Met Leu Phe Cys Tyr Gly Phe Xaa Leu Arg Xaa Leu Phe Lys 
225                 230                 235                 240 


Ala His Met Gly Gln Lys His Arg Ala Met Arg Val Ile Phe Ala Val 
                245                 250                 255     


Val Leu Ile Phe Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu 
            260                 265                 270         


Ala Asp Xaa Leu Met Arg Xaa Gln Val Ile Gln Glu Xaa Cys Glu Arg 
        275                 280                 285             


Arg Asn His Ile Asp Arg Ala Leu Asp Ala Xaa Glu Ile Leu Gly Ile 
    290                 295                 300                 


Leu His Ser Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys 
305                 310                 315                 320 


Phe Arg His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser 
                325                 330                 335     


Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser 
            340                 345                 350         


Ser Gly His Xaa Ser Xaa Xaa Leu 
        355                 360 


<210> 7396
<211> 415
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<400> 7396
Met Glu Leu Arg Lys Tyr Gly Pro Gly Arg Leu Ala Gly Xaa Val Ile 
1               5                   10                  15      


Gly Gly Ala Ala Gln Ser Lys Ser Gln Xaa Lys Ser Asp Ser Ile Xaa 
            20                  25                  30          


Lys Glu Phe Leu Pro Gly Leu Tyr Xaa Ala Pro Ser Ser Pro Phe Pro 
        35                  40                  45              


Pro Ser Gln Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val Ala 
    50                  55                  60                  


Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn Glu 
65                  70                  75                  80  


Ser Asp Ser Cys Cys Xaa Ser Pro Pro Cys Pro Gln Asp Phe Ser Leu 
                85                  90                  95      


Asn Phe Asp Arg Ala Phe Leu Pro Ala Leu Tyr Ser Leu Leu Phe Leu 
            100                 105                 110         


Leu Gly Leu Leu Gly Asn Gly Ala Val Ala Ala Val Leu Leu Ser Arg 
        115                 120                 125             


Arg Xaa Ala Leu Ser Ser Xaa Asp Xaa Phe Leu Leu His Leu Ala Val 
    130                 135                 140                 


Ala Asp Xaa Leu Leu Val Leu Xaa Leu Pro Leu Trp Ala Val Asp Ala 
145                 150                 155                 160 


Ala Val Gln Trp Val Phe Gly Ser Gly Leu Cys Lys Val Ala Gly Ala 
                165                 170                 175     


Leu Phe Asn Ile Asn Phe Tyr Ala Gly Ala Leu Leu Leu Ala Cys Ile 
            180                 185                 190         


Ser Phe Asp Arg Tyr Leu Asn Ile Val His Ala Xaa Gln Leu Tyr Arg 
        195                 200                 205             


Arg Gly Pro Pro Ala Arg Val Xaa Leu Xaa Cys Leu Ala Val Trp Gly 
    210                 215                 220                 


Leu Cys Leu Leu Phe Ala Leu Pro Asp Phe Ile Phe Leu Ser Ala His 
225                 230                 235                 240 


His Asp Glu Arg Leu Asn Ala Xaa His Cys Gln Tyr Asn Phe Pro Gln 
                245                 250                 255     


Val Gly Arg Xaa Ala Leu Arg Val Leu Gln Leu Val Ala Gly Phe Leu 
            260                 265                 270         


Leu Pro Leu Leu Val Met Ala Tyr Cys Tyr Ala His Ile Leu Ala Val 
        275                 280                 285             


Leu Leu Val Ser Arg Gly Gln Arg Arg Leu Arg Ala Met Arg Leu Val 
    290                 295                 300                 


Val Val Val Val Val Ala Phe Ala Leu Cys Trp Xaa Pro Tyr His Leu 
305                 310                 315                 320 


Val Val Leu Val Asp Ile Leu Met Asp Leu Gly Ala Leu Ala Arg Asn 
                325                 330                 335     


Cys Gly Arg Glu Ser Arg Val Asp Val Ala Lys Ser Val Xaa Ser Gly 
            340                 345                 350         


Leu Gly Tyr Met His Cys Cys Leu Asn Pro Leu Leu Tyr Ala Phe Val 
        355                 360                 365             


Gly Val Lys Phe Arg Glu Arg Met Trp Met Leu Leu Leu Arg Leu Gly 
    370                 375                 380                 


Cys Pro Asn Gln Arg Gly Leu Gln Arg Gln Pro Ser Ser Ser Arg Arg 
385                 390                 395                 400 


Asp Ser Ser Trp Ser Glu Xaa Ser Glu Ala Ser Tyr Ser Gly Leu 
                405                 410                 415 


<210> 7397
<211> 368
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<400> 7397
Met Val Leu Glu Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val 
1               5                   10                  15      


Ala Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn 
            20                  25                  30          


Glu Ser Asp Ser Cys Cys Xaa Ser Pro Pro Cys Pro Gln Asp Phe Ser 
        35                  40                  45              


Leu Asn Phe Asp Arg Ala Phe Leu Pro Ala Leu Tyr Ser Leu Leu Phe 
    50                  55                  60                  


Leu Leu Gly Leu Leu Gly Asn Gly Ala Val Ala Ala Val Leu Leu Ser 
65                  70                  75                  80  


Arg Arg Xaa Ala Leu Ser Ser Xaa Asp Xaa Phe Leu Leu His Leu Ala 
                85                  90                  95      


Val Ala Asp Xaa Leu Leu Val Leu Xaa Leu Pro Leu Trp Ala Val Asp 
            100                 105                 110         


Ala Ala Val Gln Trp Val Phe Gly Ser Gly Leu Cys Lys Val Ala Gly 
        115                 120                 125             


Ala Leu Phe Asn Ile Asn Phe Tyr Ala Gly Ala Leu Leu Leu Ala Cys 
    130                 135                 140                 


Ile Ser Phe Asp Arg Tyr Leu Asn Ile Val His Ala Xaa Gln Leu Tyr 
145                 150                 155                 160 


Arg Arg Gly Pro Pro Ala Arg Val Xaa Leu Xaa Cys Leu Ala Val Trp 
                165                 170                 175     


Gly Leu Cys Leu Leu Phe Ala Leu Pro Asp Phe Ile Phe Leu Ser Ala 
            180                 185                 190         


His His Asp Glu Arg Leu Asn Ala Xaa His Cys Gln Tyr Asn Phe Pro 
        195                 200                 205             


Gln Val Gly Arg Xaa Ala Leu Arg Val Leu Gln Leu Val Ala Gly Phe 
    210                 215                 220                 


Leu Leu Pro Leu Leu Val Met Ala Tyr Cys Tyr Ala His Ile Leu Ala 
225                 230                 235                 240 


Val Leu Leu Val Ser Arg Gly Gln Arg Arg Leu Arg Ala Met Arg Leu 
                245                 250                 255     


Val Val Val Val Val Val Ala Phe Ala Leu Cys Trp Xaa Pro Tyr His 
            260                 265                 270         


Leu Val Val Leu Val Asp Ile Leu Met Asp Leu Gly Ala Leu Ala Arg 
        275                 280                 285             


Asn Cys Gly Arg Glu Ser Arg Val Asp Val Ala Lys Ser Val Xaa Ser 
    290                 295                 300                 


Gly Leu Gly Tyr Met His Cys Cys Leu Asn Pro Leu Leu Tyr Ala Phe 
305                 310                 315                 320 


Val Gly Val Lys Phe Arg Glu Arg Met Trp Met Leu Leu Leu Arg Leu 
                325                 330                 335     


Gly Cys Pro Asn Gln Arg Gly Leu Gln Arg Gln Pro Ser Ser Ser Arg 
            340                 345                 350         


Arg Asp Ser Ser Trp Ser Glu Xaa Ser Glu Ala Ser Tyr Ser Gly Leu 
        355                 360                 365             


<210> 7398
<211> 352
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<400> 7398
Met Glu Gly Ile Ser Ile Tyr Xaa Ser Asp Asn Tyr Xaa Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu 
            20                  25                  30          


Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Xaa Ile Tyr Ser Ile Ile 
        35                  40                  45              


Phe Leu Xaa Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly 
    50                  55                  60                  


Tyr Gln Lys Lys Leu Arg Ser Met Xaa Asp Lys Tyr Arg Leu His Leu 
65                  70                  75                  80  


Ser Val Ala Asp Leu Leu Phe Val Ile Xaa Leu Pro Phe Trp Ala Val 
                85                  90                  95      


Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val 
            100                 105                 110         


His Val Ile Tyr Xaa Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala 
        115                 120                 125             


Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Xaa Asn Ser 
    130                 135                 140                 


Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val 
145                 150                 155                 160 


Trp Ile Pro Ala Leu Leu Leu Xaa Ile Pro Asp Phe Ile Phe Ala Asn 
                165                 170                 175     


Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn 
            180                 185                 190         


Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu 
        195                 200                 205             


Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser 
    210                 215                 220                 


Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Xaa 
225                 230                 235                 240 


Xaa Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr 
                245                 250                 255     


Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln 
            260                 265                 270         


Gly Cys Glu Phe Glu Asn Xaa Val His Lys Trp Ile Ser Ile Xaa Glu 
        275                 280                 285             


Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe 
    290                 295                 300                 


Leu Gly Ala Lys Phe Lys Xaa Ser Ala Gln His Ala Leu Xaa Ser Val 
305                 310                 315                 320 


Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly 
                325                 330                 335     


His Ser Ser Val Ser Xaa Glu Ser Glu Ser Ser Ser Phe His Ser Ser 
            340                 345                 350         


<210> 7399
<211> 356
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<400> 7399
Met Ser Ile Pro Leu Pro Leu Leu Gln Ile Tyr Xaa Ser Asp Asn Tyr 
1               5                   10                  15      


Xaa Glu Glu Met Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys 
            20                  25                  30          


Phe Arg Glu Glu Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Xaa Ile 
        35                  40                  45              


Tyr Ser Ile Ile Phe Leu Xaa Gly Ile Val Gly Asn Gly Leu Val Ile 
    50                  55                  60                  


Leu Val Met Gly Tyr Gln Lys Lys Leu Arg Ser Met Xaa Asp Lys Tyr 
65                  70                  75                  80  


Arg Leu His Leu Ser Val Ala Asp Leu Leu Phe Val Ile Xaa Leu Pro 
                85                  90                  95      


Phe Trp Ala Val Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu 
            100                 105                 110         


Cys Lys Ala Val His Val Ile Tyr Xaa Val Asn Leu Tyr Ser Ser Val 
        115                 120                 125             


Leu Ile Leu Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Xaa Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val 
145                 150                 155                 160 


Tyr Val Gly Val Trp Ile Pro Ala Leu Leu Leu Xaa Ile Pro Asp Phe 
                165                 170                 175     


Ile Phe Ala Asn Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg 
            180                 185                 190         


Phe Tyr Pro Asn Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile 
        195                 200                 205             


Met Val Gly Leu Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys 
    210                 215                 220                 


Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys 
225                 230                 235                 240 


Ala Leu Lys Xaa Xaa Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp 
                245                 250                 255     


Leu Pro Tyr Tyr Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu 
            260                 265                 270         


Ile Ile Lys Gln Gly Cys Glu Phe Glu Asn Xaa Val His Lys Trp Ile 
        275                 280                 285             


Ser Ile Xaa Glu Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile 
    290                 295                 300                 


Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Xaa Ser Ala Gln His Ala 
305                 310                 315                 320 


Leu Xaa Ser Val Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly 
                325                 330                 335     


Lys Arg Gly Gly His Ser Ser Val Ser Xaa Glu Ser Glu Ser Ser Ser 
            340                 345                 350         


Phe His Ser Ser 
        355     


<210> 7400
<211> 372
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(371)
<223> Selenocysteine

<400> 7400
Met Asn Tyr Pro Leu Xaa Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      


Leu Phe Trp Glu Leu Asp Arg Leu Asp Asn Tyr Asn Asp Xaa Ser Leu 
            20                  25                  30          


Val Glu Asn His Leu Cys Pro Ala Xaa Glu Gly Pro Leu Met Ala Ser 
        35                  40                  45              


Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu 
    50                  55                  60                  


Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu Arg His Arg 
65                  70                  75                  80  


Gln Xaa Arg Ser Ser Xaa Glu Xaa Phe Leu Phe His Leu Ala Val Ala 
                85                  90                  95      


Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser 
            100                 105                 110         


Val Gly Trp Val Leu Gly Xaa Phe Leu Cys Lys Xaa Val Ile Ala Leu 
        115                 120                 125             


His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala 
    130                 135                 140                 


Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His 
145                 150                 155                 160 


Arg Arg Leu Leu Ser Ile His Ile Xaa Cys Gly Xaa Ile Trp Leu Val 
                165                 170                 175     


Gly Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys Val Ser Gln 
            180                 185                 190         


Gly His His Asn Asn Ser Leu Pro Arg Cys Xaa Phe Ser Gln Glu Asn 
        195                 200                 205             


Gln Ala Glu Xaa His Ala Trp Phe Xaa Ser Arg Phe Leu Tyr His Val 
    210                 215                 220                 


Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly 
225                 230                 235                 240 


Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys 
                245                 250                 255     


Ala Val Arg Val Ala Ile Leu Val Xaa Ser Ile Phe Phe Leu Cys Trp 
            260                 265                 270         


Ser Pro Tyr His Ile Val Ile Phe Leu Asp Xaa Leu Ala Arg Leu Lys 
        275                 280                 285             


Ala Val Asp Asn Xaa Cys Lys Leu Asn Gly Ser Leu Pro Val Ala Ile 
    290                 295                 300                 


Xaa Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met 
305                 310                 315                 320 


Leu Tyr Xaa Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu 
                325                 330                 335     


Leu Xaa Lys Leu Gly Cys Xaa Gly Pro Ala Ser Leu Cys Gln Leu Phe 
            340                 345                 350         


Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn Ala Xaa Ser 
        355                 360                 365             


Leu Xaa Xaa Phe 
    370         


<210> 7401
<211> 342
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<400> 7401
Met Ala Glu His Asp Tyr His Glu Asp Tyr Gly Phe Ser Ser Phe Asn 
1               5                   10                  15      


Asp Ser Ser Gln Glu Glu His Gln Asp Phe Leu Gln Phe Ser Lys Val 
            20                  25                  30          


Phe Leu Pro Cys Met Tyr Leu Val Val Phe Val Cys Gly Leu Val Gly 
        35                  40                  45              


Asn Ser Leu Val Leu Val Ile Ser Ile Phe Tyr His Lys Leu Gln Ser 
    50                  55                  60                  


Leu Xaa Asp Val Phe Leu Val Asn Leu Pro Leu Ala Asp Leu Val Phe 
65                  70                  75                  80  


Val Cys Xaa Leu Pro Phe Trp Ala Tyr Ala Gly Ile His Glu Trp Val 
                85                  90                  95      


Phe Gly Gln Val Met Cys Lys Ser Leu Leu Gly Ile Tyr Xaa Ile Asn 
            100                 105                 110         


Phe Tyr Xaa Ser Met Leu Ile Leu Xaa Cys Ile Xaa Val Asp Arg Phe 
        115                 120                 125             


Ile Val Val Val Lys Ala Xaa Lys Ala Tyr Asn Gln Gln Ala Lys Arg 
    130                 135                 140                 


Met Xaa Trp Gly Lys Val Xaa Ser Leu Leu Ile Trp Val Ile Ser Leu 
145                 150                 155                 160 


Leu Val Ser Leu Pro Gln Ile Ile Tyr Gly Asn Val Phe Asn Leu Asp 
                165                 170                 175     


Lys Leu Ile Cys Gly Tyr His Asp Glu Ala Ile Ser Xaa Val Val Leu 
            180                 185                 190         


Ala Xaa Gln Met Xaa Leu Gly Phe Phe Leu Pro Leu Leu Xaa Met Ile 
        195                 200                 205             


Val Cys Tyr Ser Val Ile Ile Lys Xaa Leu Leu His Ala Gly Gly Phe 
    210                 215                 220                 


Gln Lys His Arg Ser Leu Lys Ile Ile Phe Leu Val Met Ala Val Phe 
225                 230                 235                 240 


Leu Leu Xaa Gln Met Pro Phe Asn Leu Met Lys Phe Ile Arg Ser Xaa 
                245                 250                 255     


His Trp Glu Tyr Tyr Ala Met Xaa Ser Phe His Tyr Xaa Ile Met Val 
            260                 265                 270         


Xaa Glu Ala Ile Ala Tyr Leu Arg Ala Cys Leu Asn Pro Val Leu Tyr 
        275                 280                 285             


Ala Phe Val Ser Leu Lys Phe Arg Lys Asn Phe Trp Lys Leu Val Lys 
    290                 295                 300                 


Asp Ile Gly Cys Leu Pro Tyr Leu Gly Val Ser His Gln Trp Lys Ser 
305                 310                 315                 320 


Ser Glu Asp Asn Ser Lys Xaa Phe Ser Ala Ser His Asn Val Glu Ala 
                325                 330                 335     


Xaa Ser Met Phe Gln Leu 
            340         


<210> 7402
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<400> 7402
Met Glu Pro Gln Leu Gly Pro Glu Ala Ala Ala Leu Arg Pro Gly Trp 
1               5                   10                  15      


Leu Ala Leu Leu Leu Trp Val Ser Ala Leu Ser Cys Ser Phe Ser Leu 
            20                  25                  30          


Pro Ala Ser Ser Leu Ser Ser Leu Val Pro Gln Val Arg Xaa Ser Tyr 
        35                  40                  45              


Asn Phe Gly Arg Xaa Phe Leu Gly Leu Asp Lys Cys Asn Ala Cys Ile 
    50                  55                  60                  


Gly Xaa Ser Ile Cys Lys Lys Phe Phe Lys Glu Glu Ile Arg Ser Asp 
65                  70                  75                  80  


Asn Trp Leu Ala Ser His Leu Gly Leu Pro Pro Asp Ser Leu Leu Ser 
                85                  90                  95      


Tyr Pro Ala Asn Tyr Ser Asp Asp Ser Lys Ile Trp Arg Pro Val Glu 
            100                 105                 110         


Ile Phe Arg Leu Val Ser Lys Tyr Gln Asn Glu Ile Ser Asp Arg Arg 
        115                 120                 125             


Ile Cys Ala Ser Ala Ser Ala Pro Lys Xaa Cys Ser Ile Glu Arg Val 
    130                 135                 140                 


Leu Arg Lys Xaa Glu Arg Phe Gln Lys Trp Leu Gln Ala Lys Arg Leu 
145                 150                 155                 160 


Xaa Pro Asp Leu Val Gln Asp Cys His Gln Gly Gln Arg Glu Leu Lys 
                165                 170                 175     


Phe Leu Cys Met Leu Arg 
            180         


<210> 7403
<211> 433
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<400> 7403
Met Glu Pro Gln Leu Gly Pro Glu Ala Ala Ala Leu Arg Pro Gly Trp 
1               5                   10                  15      


Leu Ala Leu Leu Leu Trp Val Ser Ala Leu Ser Cys Ser Phe Ser Leu 
            20                  25                  30          


Pro Ala Ser Ser Leu Ser Ser Leu Val Pro Gln Val Arg Xaa Ser Tyr 
        35                  40                  45              


Asn Phe Gly Arg Xaa Phe Leu Gly Leu Asp Lys Cys Asn Ala Cys Ile 
    50                  55                  60                  


Gly Xaa Ser Ile Cys Lys Lys Phe Phe Lys Glu Glu Ile Arg Ser Asp 
65                  70                  75                  80  


Asn Trp Leu Ala Ser His Leu Gly Leu Pro Pro Asp Ser Leu Leu Ser 
                85                  90                  95      


Tyr Pro Ala Asn Tyr Ser Asp Asp Ser Lys Ile Trp Arg Pro Val Glu 
            100                 105                 110         


Ile Phe Arg Leu Val Ser Lys Tyr Gln Asn Glu Ile Ser Asp Arg Arg 
        115                 120                 125             


Ile Cys Ala Ser Ala Ser Ala Pro Lys Xaa Cys Ser Ile Glu Arg Val 
    130                 135                 140                 


Leu Arg Lys Xaa Glu Arg Phe Gln Lys Trp Leu Gln Ala Lys Arg Leu 
145                 150                 155                 160 


Xaa Pro Asp Leu Val Gln Gly Leu Ala Ser Pro Leu Leu Arg Cys Pro 
                165                 170                 175     


Ser Gln Arg Leu Leu Asp Arg Val Val Arg Arg Tyr Ala Glu Val Ala 
            180                 185                 190         


Asp Ala Gly Ser Ile Phe Met Asp His Phe Xaa Asp Arg Asp Lys Leu 
        195                 200                 205             


Arg Leu Leu Tyr Xaa Leu Ala Val Asn Ser His Pro Ile Leu Leu Gln 
    210                 215                 220                 


Ile Phe Pro Gly Ala Glu Gly Trp Pro Leu Pro Lys Tyr Leu Gly Ser 
225                 230                 235                 240 


Cys Gly Arg Phe Leu Val Ser Xaa Ser Xaa Arg Pro Leu Gln Glu Phe 
                245                 250                 255     


Tyr Asp Ala Pro Pro Asp Gln Ala Ala Asp Leu Ala Tyr Gln Leu Leu 
            260                 265                 270         


Gly Val Leu Glu Ser Leu Arg Ser Asn Asp Leu Asn Tyr Phe Phe Tyr 
        275                 280                 285             


Phe Xaa His Ile Asp Ala Gly Met Phe Gly Val Phe Asn Asn Gly His 
    290                 295                 300                 


Leu Phe Ile Arg Asp Ala Ser Ala Val Gly Val Ile Asp Lys Gln Glu 
305                 310                 315                 320 


Gly Ser Gln Glu Ala Asn Arg Ala Gly Glu Asn Lys Asp Ile Phe Ser 
                325                 330                 335     


Cys Leu Val Ser Gly Cys Gln Ala Gln Leu Pro Ser Cys Glu Ser Ile 
            340                 345                 350         


Ser Glu Lys Gln Ser Leu Val Leu Val Cys Gln Lys Leu Leu Pro Arg 
        355                 360                 365             


Leu Leu Gln Gly Arg Phe Pro Ser Pro Val Gln Asp Asp Ile Asp Ser 
    370                 375                 380                 


Ile Leu Val Gln Cys Gly Asp Ser Ile Arg Pro Asp Pro Glu Val Leu 
385                 390                 395                 400 


Gly Ala Ala Ser Gln Leu Lys Asp Ile Leu Arg Pro Leu Arg Xaa Cys 
                405                 410                 415     


Asp Ser Arg Phe Ala Tyr Arg Tyr Pro Asp Cys Lys Tyr Asn Asp Lys 
            420                 425                 430         


Phe 
    


<210> 7404
<211> 8
<212> PRT
<213> Homo sapiens

<400> 7404
Met Ser Ser Leu Gly Gly Gly Ser 
1               5               


<210> 7405
<211> 11
<212> PRT
<213> Homo sapiens

<400> 7405
Met Ser Ser Leu Gly Gly Gly Ser Gln Asp Ala 
1               5                   10      


<210> 7406
<211> 69
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 7406
Met Ser Ser Leu Gly Gly Gly Ser Gln Asp Ala Gly Gly Ser Ser Ser 
1               5                   10                  15      


Ser Ser Xaa Asn Gly Ser Gly Gly Ser Gly Ser Ser Gly Pro Lys Ala 
            20                  25                  30          


Gly Ala Ala Asp Lys Ser Ala Val Val Ala Ala Ala Ala Pro Ala Ser 
        35                  40                  45              


Val Ala Asp Asp Xaa Pro Pro Pro Glu Arg Arg Asn Lys Ser Gly Ile 
    50                  55                  60                  


Ile Ser Glu Pro Leu 
65                  


<210> 7407
<211> 73
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 7407
Met Ser Ser Leu Gly Gly Gly Ser Gln Asp Ala Gly Gly Ser Ser Ser 
1               5                   10                  15      


Ser Ser Xaa Asn Gly Ser Gly Gly Ser Gly Ser Ser Gly Pro Lys Ala 
            20                  25                  30          


Gly Ala Ala Asp Lys Ser Ala Val Val Ala Ala Ala Ala Pro Ala Ser 
        35                  40                  45              


Val Ala Asp Asp Xaa Pro Pro Pro Glu Arg Arg Asn Lys Ser Gly Ile 
    50                  55                  60                  


Ile Ser Glu Pro Leu Asn Lys Ser Leu 
65                  70              


<210> 7408
<211> 80
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 7408
Met Ser Ser Leu Gly Gly Gly Ser Gln Asp Ala Gly Gly Ser Ser Ser 
1               5                   10                  15      


Ser Ser Xaa Asn Gly Ser Gly Gly Ser Gly Ser Ser Gly Pro Lys Ala 
            20                  25                  30          


Gly Ala Ala Asp Lys Ser Ala Val Val Ala Ala Ala Ala Pro Ala Ser 
        35                  40                  45              


Val Ala Asp Asp Xaa Pro Pro Pro Glu Arg Arg Asn Lys Ser Gly Ile 
    50                  55                  60                  


Ile Ser Glu Pro Leu Asn Lys Ser Leu Arg Arg Ser Arg Pro Leu Ser 
65                  70                  75                  80  


<210> 7409
<211> 83
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 7409
Met Ser Ser Leu Gly Gly Gly Ser Gln Asp Ala Gly Gly Ser Ser Ser 
1               5                   10                  15      


Ser Ser Xaa Asn Gly Ser Gly Gly Ser Gly Ser Ser Gly Pro Lys Ala 
            20                  25                  30          


Gly Ala Ala Asp Lys Ser Ala Val Val Ala Ala Ala Ala Pro Ala Ser 
        35                  40                  45              


Val Ala Asp Asp Xaa Pro Pro Pro Glu Arg Arg Asn Lys Ser Gly Ile 
    50                  55                  60                  


Ile Ser Glu Pro Leu Asn Lys Ser Leu Arg Arg Ser Arg Pro Leu Ser 
65                  70                  75                  80  


His Tyr Ser 
            


<210> 7410
<211> 98
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 7410
Met Ser Ser Leu Gly Gly Gly Ser Gln Asp Ala Gly Gly Ser Ser Ser 
1               5                   10                  15      


Ser Ser Xaa Asn Gly Ser Gly Gly Ser Gly Ser Ser Gly Pro Lys Ala 
            20                  25                  30          


Gly Ala Ala Asp Lys Ser Ala Val Val Ala Ala Ala Ala Pro Ala Ser 
        35                  40                  45              


Val Ala Asp Asp Xaa Pro Pro Pro Glu Arg Arg Asn Lys Ser Gly Ile 
    50                  55                  60                  


Ile Ser Glu Pro Leu Asn Lys Ser Leu Arg Arg Ser Arg Pro Leu Ser 
65                  70                  75                  80  


His Tyr Ser Ser Phe Gly Ser Ser Gly Gly Ser Gly Gly Gly Ser Met 
                85                  90                  95      


Met Gly 
        


<210> 7411
<211> 102
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<400> 7411
Met Ser Ser Leu Gly Gly Gly Ser Gln Asp Ala Gly Gly Ser Ser Ser 
1               5                   10                  15      


Ser Ser Xaa Asn Gly Ser Gly Gly Ser Gly Ser Ser Gly Pro Lys Ala 
            20                  25                  30          


Gly Ala Ala Asp Lys Ser Ala Val Val Ala Ala Ala Ala Pro Ala Ser 
        35                  40                  45              


Val Ala Asp Asp Xaa Pro Pro Pro Glu Arg Arg Asn Lys Ser Gly Ile 
    50                  55                  60                  


Ile Ser Glu Pro Leu Asn Lys Ser Leu Arg Arg Ser Arg Pro Leu Ser 
65                  70                  75                  80  


His Tyr Ser Ser Phe Gly Ser Ser Gly Gly Ser Gly Gly Gly Ser Met 
                85                  90                  95      


Met Gly Gly Glu Ser Ala 
            100         


<210> 7412
<211> 137
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<400> 7412
Met Ser Ser Leu Gly Gly Gly Ser Gln Asp Ala Gly Gly Ser Ser Ser 
1               5                   10                  15      


Ser Ser Xaa Asn Gly Ser Gly Gly Ser Gly Ser Ser Gly Pro Lys Ala 
            20                  25                  30          


Gly Ala Ala Asp Lys Ser Ala Val Val Ala Ala Ala Ala Pro Ala Ser 
        35                  40                  45              


Val Ala Asp Asp Xaa Pro Pro Pro Glu Arg Arg Asn Lys Ser Gly Ile 
    50                  55                  60                  


Ile Ser Glu Pro Leu Asn Lys Ser Leu Arg Arg Ser Arg Pro Leu Ser 
65                  70                  75                  80  


His Tyr Ser Ser Phe Gly Ser Ser Gly Gly Ser Gly Gly Gly Ser Met 
                85                  90                  95      


Met Gly Gly Glu Ser Ala Asp Lys Ala Xaa Ala Ala Ala Ala Ala Ala 
            100                 105                 110         


Ser Leu Leu Ala Asn Gly His Asp Leu Ala Ala Ala Met Ala Val Asp 
        115                 120                 125             


Lys Ser Asn Pro Xaa Ser Lys His Lys 
    130                 135         


<210> 7413
<211> 161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<400> 7413
Met Ser Ser Leu Gly Gly Gly Ser Gln Asp Ala Gly Gly Ser Ser Ser 
1               5                   10                  15      


Ser Ser Xaa Asn Gly Ser Gly Gly Ser Gly Ser Ser Gly Pro Lys Ala 
            20                  25                  30          


Gly Ala Ala Asp Lys Ser Ala Val Val Ala Ala Ala Ala Pro Ala Ser 
        35                  40                  45              


Val Ala Asp Asp Xaa Pro Pro Pro Glu Arg Arg Asn Lys Ser Gly Ile 
    50                  55                  60                  


Ile Ser Glu Pro Leu Asn Lys Ser Leu Arg Arg Ser Arg Pro Leu Ser 
65                  70                  75                  80  


His Tyr Ser Ser Phe Gly Ser Ser Gly Gly Ser Gly Gly Gly Ser Met 
                85                  90                  95      


Met Gly Gly Glu Ser Ala Asp Lys Ala Xaa Ala Ala Ala Ala Ala Ala 
            100                 105                 110         


Ser Leu Leu Ala Asn Gly His Asp Leu Ala Ala Ala Met Ala Val Asp 
        115                 120                 125             


Lys Ser Asn Pro Xaa Ser Lys His Lys Ser Gly Ala Val Ala Ser Leu 
    130                 135                 140                 


Leu Ser Lys Ala Glu Arg Ala Xaa Glu Leu Ala Ala Glu Gly Gln Leu 
145                 150                 155                 160 


Xaa 
    


<210> 7414
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 7414
Met Ser Ser Leu Gly Gly Gly Ser Gln Asp Ala Gly Gly Ser Ser Ser 
1               5                   10                  15      


Ser Ser Xaa Asn Gly Ser Gly Gly Ser Gly Ser Ser Gly Pro Lys Ala 
            20                  25                  30          


Gly Ala Ala Asp Lys Ser Ala Val Val Ala Ala Ala Ala Pro Ala Ser 
        35                  40                  45              


Val Ala Asp Asp Xaa Pro Pro Pro Glu Arg Arg Asn Lys Ser Gly Ile 
    50                  55                  60                  


Ile Ser Glu Pro Leu Asn Lys Ser Leu Arg Arg Ser Arg Pro Leu Ser 
65                  70                  75                  80  


His Tyr Ser Ser Phe Gly Ser Ser Gly Gly Ser Gly Gly Gly Ser Met 
                85                  90                  95      


Met Gly Gly Glu Ser Ala Asp Lys Ala Xaa Ala Ala Ala Ala Ala Ala 
            100                 105                 110         


Ser Leu Leu Ala Asn Gly His Asp Leu Ala Ala Ala Met Ala Val Asp 
        115                 120                 125             


Lys Ser Asn Pro Xaa Ser Lys His Lys Ser Gly Ala Val Ala Ser Leu 
    130                 135                 140                 


Leu Ser Lys Ala Glu Arg Ala Xaa Glu Leu Ala Ala Glu Gly Gln Leu 
145                 150                 155                 160 


Xaa Leu Gln Gln Phe Ala Gln Ser Xaa Glu Met Leu Lys Arg Val Val 
                165                 170                 175     


Gln Glu His Leu Pro 
            180     


<210> 7415
<211> 197
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<400> 7415
Met Ser Ser Leu Gly Gly Gly Ser Gln Asp Ala Gly Gly Ser Ser Ser 
1               5                   10                  15      


Ser Ser Xaa Asn Gly Ser Gly Gly Ser Gly Ser Ser Gly Pro Lys Ala 
            20                  25                  30          


Gly Ala Ala Asp Lys Ser Ala Val Val Ala Ala Ala Ala Pro Ala Ser 
        35                  40                  45              


Val Ala Asp Asp Xaa Pro Pro Pro Glu Arg Arg Asn Lys Ser Gly Ile 
    50                  55                  60                  


Ile Ser Glu Pro Leu Asn Lys Ser Leu Arg Arg Ser Arg Pro Leu Ser 
65                  70                  75                  80  


His Tyr Ser Ser Phe Gly Ser Ser Gly Gly Ser Gly Gly Gly Ser Met 
                85                  90                  95      


Met Gly Gly Glu Ser Ala Asp Lys Ala Xaa Ala Ala Ala Ala Ala Ala 
            100                 105                 110         


Ser Leu Leu Ala Asn Gly His Asp Leu Ala Ala Ala Met Ala Val Asp 
        115                 120                 125             


Lys Ser Asn Pro Xaa Ser Lys His Lys Ser Gly Ala Val Ala Ser Leu 
    130                 135                 140                 


Leu Ser Lys Ala Glu Arg Ala Xaa Glu Leu Ala Ala Glu Gly Gln Leu 
145                 150                 155                 160 


Xaa Leu Gln Gln Phe Ala Gln Ser Xaa Glu Met Leu Lys Arg Val Val 
                165                 170                 175     


Gln Glu His Leu Pro Leu Met Ser Glu Ala Gly Ala Gly Leu Pro Asp 
            180                 185                 190         


Met Glu Ala Val Ala 
        195         


<210> 7416
<211> 322
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (161)..(161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<400> 7416
Met Ser Ser Leu Gly Gly Gly Ser Gln Asp Ala Gly Gly Ser Ser Ser 
1               5                   10                  15      


Ser Ser Xaa Asn Gly Ser Gly Gly Ser Gly Ser Ser Gly Pro Lys Ala 
            20                  25                  30          


Gly Ala Ala Asp Lys Ser Ala Val Val Ala Ala Ala Ala Pro Ala Ser 
        35                  40                  45              


Val Ala Asp Asp Xaa Pro Pro Pro Glu Arg Arg Asn Lys Ser Gly Ile 
    50                  55                  60                  


Ile Ser Glu Pro Leu Asn Lys Ser Leu Arg Arg Ser Arg Pro Leu Ser 
65                  70                  75                  80  


His Tyr Ser Ser Phe Gly Ser Ser Gly Gly Ser Gly Gly Gly Ser Met 
                85                  90                  95      


Met Gly Gly Glu Ser Ala Asp Lys Ala Xaa Ala Ala Ala Ala Ala Ala 
            100                 105                 110         


Ser Leu Leu Ala Asn Gly His Asp Leu Ala Ala Ala Met Ala Val Asp 
        115                 120                 125             


Lys Ser Asn Pro Xaa Ser Lys His Lys Ser Gly Ala Val Ala Ser Leu 
    130                 135                 140                 


Leu Ser Lys Ala Glu Arg Ala Xaa Glu Leu Ala Ala Glu Gly Gln Leu 
145                 150                 155                 160 


Xaa Leu Gln Gln Phe Ala Gln Ser Xaa Glu Met Leu Lys Arg Val Val 
                165                 170                 175     


Gln Glu His Leu Pro Leu Met Ser Glu Ala Gly Ala Gly Leu Pro Asp 
            180                 185                 190         


Met Glu Ala Val Ala Gly Ala Glu Ala Leu Asn Gly Gln Ser Asp Phe 
        195                 200                 205             


Pro Tyr Leu Gly Ala Phe Pro Ile Asn Pro Gly Leu Phe Ile Met Xaa 
    210                 215                 220                 


Pro Ala Gly Val Phe Leu Ala Glu Ser Ala Leu His Met Ala Gly Leu 
225                 230                 235                 240 


Ala Glu Tyr Pro Met Gln Gly Glu Leu Ala Ser Ala Ile Ser Ser Gly 
                245                 250                 255     


Lys Lys Lys Arg Lys Arg Cys Gly Met Cys Ala Pro Cys Arg Arg Arg 
            260                 265                 270         


Ile Asn Cys Glu Gln Cys Ser Ser Cys Arg Asn Arg Lys Xaa Gly His 
        275                 280                 285             


Gln Ile Cys Lys Phe Arg Lys Cys Glu Glu Leu Lys Lys Lys Pro Ser 
    290                 295                 300                 


Ala Ala Leu Glu Lys Val Met Leu Pro Xaa Gly Ala Ala Phe Arg Trp 
305                 310                 315                 320 


Phe Gln 
        


<210> 7417
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<400> 7417
Met Asp Pro Leu Gly Xaa Arg Ala Arg Glu Cys Leu Ala Gln His Gly 
1               5                   10                  15      


Pro His His Arg Gly His Arg Gly His Ser Trp Ala Leu His Pro Val 
            20                  25                  30          


Val Leu Trp Cys Leu Leu His Cys Gly Gly Arg Val Cys Val Pro Ala 
        35                  40                  45              


Gly Val Pro Pro Gly Glu Glu Glu Glu Gly Leu His His Gly Ala Leu 
    50                  55                  60                  


Gly Xaa Glu Val His Asp Arg Arg Gly Glu Ala Val Arg Ala Leu Tyr 
65                  70                  75                  80  


Gln Glu Leu Leu Cys Ser Gly Arg Pro Ala Ser Pro Ala Leu Gly Ala 
                85                  90                  95      


Arg Arg Leu Pro Ala Gly His His Pro Trp Asp Arg Leu Pro Gly His 
            100                 105                 110         


Cys Glu Arg His Leu Pro Xaa Gly Gly Cys Ala Trp Arg Ala Val Asp 
        115                 120                 125             


Ala His 
    130 


<210> 7418
<211> 145
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<400> 7418
Met Gly Gln Ile Glu Trp Ala Met Trp Ala Asn Glu Gln Ala Leu Ala 
1               5                   10                  15      


Ser Gly Leu Ile Leu Ile Xaa Gly Gly Ile Val Ala Xaa Ala Gly Arg 
            20                  25                  30          


Phe Xaa Gln Trp Tyr Phe Gly Ala Tyr Ser Ile Val Ala Gly Val Phe 
        35                  40                  45              


Val Cys Leu Leu Glu Tyr Pro Arg Gly Lys Arg Lys Lys Gly Ser Xaa 
    50                  55                  60                  


Met Glu Arg Trp Gly Gln Lys Tyr Met Xaa Ala Val Val Lys Leu Phe 
65                  70                  75                  80  


Gly Pro Phe Xaa Arg Asn Tyr Tyr Val Arg Ala Val Leu His Leu Leu 
                85                  90                  95      


Ala Cys Val Cys Cys Leu Val Cys Arg Ile Cys Lys Asp Pro Leu Gln 
            100                 105                 110         


Ile Arg Gly Ala Pro Ile Arg Arg Gln Gly Leu Gly Leu Ser Val Pro 
        115                 120                 125             


Ala Gly Phe Leu Leu Ala Xaa Ile Leu Gly Xaa Ala Cys Leu Ala Ile 
    130                 135                 140                 


Ala 
145 


<210> 7419
<211> 195
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<400> 7419
Met Gly Gln Ile Glu Trp Ala Met Trp Ala Asn Glu Gln Ala Leu Ala 
1               5                   10                  15      


Ser Gly Leu Ile Leu Ile Xaa Gly Gly Ile Val Ala Xaa Ala Gly Arg 
            20                  25                  30          


Phe Xaa Gln Trp Tyr Phe Gly Ala Tyr Ser Ile Val Ala Gly Val Phe 
        35                  40                  45              


Val Cys Leu Leu Glu Tyr Pro Arg Gly Lys Arg Lys Lys Gly Ser Xaa 
    50                  55                  60                  


Met Glu Arg Trp Gly Gln Lys Tyr Met Xaa Ala Val Val Lys Leu Phe 
65                  70                  75                  80  


Gly Pro Phe Xaa Arg Asn Tyr Tyr Val Arg Ala Val Leu His Leu Leu 
                85                  90                  95      


Leu Ser Val Pro Ala Gly Phe Leu Leu Ala Xaa Ile Leu Gly Xaa Ala 
            100                 105                 110         


Cys Leu Ala Ile Ala Ser Gly Ile Tyr Leu Leu Ala Ala Val Arg Gly 
        115                 120                 125             


Glu Gln Trp Xaa Pro Ile Glu Pro Lys Pro Arg Glu Arg Pro Gln Ile 
    130                 135                 140                 


Gly Gly Xaa Ile Lys Gln Pro Pro Ser Asn Pro Pro Pro Arg Pro Pro 
145                 150                 155                 160 


Ala Glu Ala Arg Lys Lys Pro Ser Glu Glu Glu Ala Ala Val Ala Ala 
                165                 170                 175     


Gly Gly Pro Pro Gly Gly Pro Gln Val Asn Pro Ile Pro Val Xaa Asp 
            180                 185                 190         


Glu Val Val 
        195 


<210> 7420
<211> 210
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<400> 7420
Met Gly Gln Ile Glu Trp Ala Met Trp Ala Asn Glu Gln Ala Leu Ala 
1               5                   10                  15      


Ser Gly Leu Ile Leu Ile Xaa Gly Gly Ile Val Ala Xaa Ala Gly Arg 
            20                  25                  30          


Phe Xaa Gln Trp Tyr Phe Gly Ala Tyr Ser Ile Val Ala Gly Val Phe 
        35                  40                  45              


Val Cys Leu Leu Glu Tyr Pro Arg Gly Lys Arg Lys Lys Gly Ser Xaa 
    50                  55                  60                  


Met Glu Arg Trp Gly Gln Lys Tyr Met Xaa Ala Val Val Lys Leu Phe 
65                  70                  75                  80  


Gly Pro Phe Xaa Arg Asn Tyr Tyr Val Arg Ala Val Leu His Leu Leu 
                85                  90                  95      


Leu Ser Val Pro Ala Gly Phe Leu Leu Ala Xaa Ile Leu Gly Xaa Ala 
            100                 105                 110         


Cys Leu Ala Ile Ala Ser Gly Ile Tyr Leu Leu Ser Gln Val Pro Pro 
        115                 120                 125             


Ala Arg Arg Gly Asn Cys Pro Pro Leu Ala Val Arg Leu Leu Val Cys 
    130                 135                 140                 


Val Arg Gly Lys Gly Ala Ala Leu Ser Val Tyr Ala Phe Arg Val Trp 
145                 150                 155                 160 


Lys Trp Ser Ser Val Ser Ser Leu Xaa Asp Leu Pro Pro Ala Glu Leu 
                165                 170                 175     


Ser Phe Arg Xaa Pro Ser Cys Cys Gln Val Leu Ile Trp Ala Val Ala 
            180                 185                 190         


Leu Phe Ser Gly Gly His Pro His Pro Pro Arg Leu Pro Ala Ala Xaa 
        195                 200                 205             


His Ser 
    210 


<210> 7421
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 7421
Met Gly Gln Ile Glu Trp Ala Met Trp Ala Asn Glu Gln Ala Leu Ala 
1               5                   10                  15      


Ser Gly Leu Ile Leu Ile Xaa Gly Gly Ile Val Ala Xaa Ala Gly Arg 
            20                  25                  30          


Phe Xaa Gln Trp Tyr Phe Gly Ala Tyr Ser Ile Val Ala Gly Val Phe 
        35                  40                  45              


Val Cys Leu Leu Glu Tyr Pro Arg Gly Lys Arg Lys Lys Gly Ser Xaa 
    50                  55                  60                  


Met Glu Arg Trp Gly Gln Lys Tyr Met Xaa Ala Val Val Lys Leu Phe 
65                  70                  75                  80  


Gly Pro Phe Xaa Arg Asn Tyr Tyr Val Arg Ala Val Leu His Leu Leu 
                85                  90                  95      


Leu Ser Val Pro Ala Gly Phe Leu Leu Ala Xaa Ile Leu Gly Xaa Ala 
            100                 105                 110         


Cys Leu Ala Ile Ala Ser Gly Ile Tyr Leu Leu Val Ser Gly Ala Leu 
        115                 120                 125             


<210> 7422
<211> 74
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<400> 7422
Xaa Asp Arg Arg Gly Glu Ala Val Arg Ala Leu Tyr Gln Glu Leu Leu 
1               5                   10                  15      


Cys Ser Gly Arg Pro Ala Ser Pro Ala Leu Gly Ala Arg Arg Leu Pro 
            20                  25                  30          


Ala Gly His His Pro Trp Asp Arg Leu Pro Gly His Cys Glu Arg His 
        35                  40                  45              


Leu Pro Xaa Val Pro Arg Arg Arg Leu Cys Val Ala Ser Ser Gly Arg 
    50                  55                  60                  


Pro Ser Ser Pro Ser Pro Gly Ser Gly Arg 
65                  70                  


<210> 7423
<211> 570
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<400> 7423
Met Gly Asn Trp Ala Val Asn Glu Gly Leu Ser Ile Phe Val Ile Leu 
1               5                   10                  15      


Val Trp Leu Gly Leu Asn Val Phe Leu Phe Val Trp Tyr Tyr Arg Val 
            20                  25                  30          


Tyr Asp Ile Pro Pro Lys Phe Phe Tyr Xaa Arg Lys Leu Leu Gly Ser 
        35                  40                  45              


Ala Leu Ala Leu Ala Arg Ala Pro Ala Ala Cys Leu Asn Phe Asn Cys 
    50                  55                  60                  


Met Leu Ile Leu Leu Pro Val Cys Arg Asn Leu Leu Ser Phe Leu Arg 
65                  70                  75                  80  


Gly Ser Ser Ala Cys Cys Ser Xaa Arg Val Arg Arg Gln Leu Asp Arg 
                85                  90                  95      


Asn Leu Xaa Phe His Lys Met Val Ala Trp Met Ile Ala Leu His Ser 
            100                 105                 110         


Ala Ile His Xaa Ile Ala His Leu Phe Asn Val Glu Trp Cys Val Asn 
        115                 120                 125             


Ala Arg Val Asn Asn Ser Asp Pro Tyr Ser Val Ala Leu Ser Glu Leu 
    130                 135                 140                 


Gly Asp Arg Gln Asn Glu Ser Tyr Leu Asn Phe Ala Arg Lys Arg Ile 
145                 150                 155                 160 


Lys Asn Pro Glu Gly Gly Leu Tyr Leu Ala Val Xaa Leu Leu Ala Gly 
                165                 170                 175     


Ile Xaa Gly Val Val Ile Xaa Leu Cys Leu Ile Leu Ile Ile Xaa Ser 
            180                 185                 190         


Ser Xaa Lys Xaa Ile Arg Arg Ser Tyr Phe Glu Val Phe Trp Tyr Xaa 
        195                 200                 205             


His His Leu Phe Val Ile Phe Phe Ile Gly Leu Ala Ile His Gly Ala 
    210                 215                 220                 


Glu Arg Ile Val Arg Gly Gln Xaa Ala Glu Ser Leu Ala Val His Asn 
225                 230                 235                 240 


Ile Xaa Val Cys Glu Gln Lys Ile Ser Glu Trp Gly Lys Ile Lys Glu 
                245                 250                 255     


Cys Pro Ile Pro Gln Phe Ala Gly Asn Pro Pro Met Xaa Trp Lys Trp 
            260                 265                 270         


Ile Val Gly Pro Met Phe Leu Tyr Leu Cys Glu Arg Leu Val Arg Phe 
        275                 280                 285             


Trp Arg Ser Gln Gln Lys Val Val Ile Xaa Lys Val Val Xaa His Pro 
    290                 295                 300                 


Phe Lys Xaa Ile Glu Leu Gln Met Lys Lys Lys Gly Phe Lys Met Glu 
305                 310                 315                 320 


Val Gly Gln Tyr Ile Phe Val Lys Cys Pro Lys Val Ser Lys Leu Glu 
                325                 330                 335     


Trp His Pro Phe Xaa Leu Xaa Ser Ala Pro Glu Glu Asp Phe Phe Ser 
            340                 345                 350         


Ile His Ile Arg Ile Val Gly Asp Trp Xaa Glu Gly Leu Phe Asn Ala 
        355                 360                 365             


Cys Gly Cys Asp Lys Gln Glu Phe Gln Asp Ala Trp Lys Leu Pro Lys 
    370                 375                 380                 


Ile Ala Val Asp Gly Pro Phe Gly Xaa Ala Ser Glu Asp Val Phe Ser 
385                 390                 395                 400 


Tyr Glu Val Val Met Leu Val Gly Ala Gly Ile Gly Val Xaa Pro Phe 
                405                 410                 415     


Ala Ser Ile Leu Lys Ser Val Trp Tyr Lys Tyr Cys Asn Asn Ala Xaa 
            420                 425                 430         


Asn Leu Lys Leu Lys Lys Ile Tyr Phe Tyr Trp Leu Cys Arg Asp Xaa 
        435                 440                 445             


His Ala Phe Glu Trp Phe Ala Asp Leu Leu Gln Leu Leu Glu Ser Gln 
    450                 455                 460                 


Met Gln Glu Arg Asn Asn Ala Gly Phe Leu Ser Tyr Asn Ile Tyr Leu 
465                 470                 475                 480 


Xaa Gly Trp Asp Glu Ser Gln Ala Asn His Phe Ala Val His His Asp 
                485                 490                 495     


Glu Glu Lys Asp Val Ile Xaa Gly Leu Lys Gln Lys Xaa Leu Tyr Gly 
            500                 505                 510         


Arg Pro Asn Trp Asp Asn Glu Phe Lys Xaa Ile Ala Ser Gln His Pro 
        515                 520                 525             


Asn Xaa Arg Ile Gly Val Phe Leu Cys Gly Pro Glu Ala Leu Ala Glu 
    530                 535                 540                 


Xaa Leu Ser Lys Gln Ser Ile Ser Asn Ser Glu Ser Gly Pro Arg Gly 
545                 550                 555                 560 


Val His Phe Ile Phe Asn Lys Glu Asn Phe 
                565                 570 


<210> 7424
<211> 101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<400> 7424
Met Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Ile Met Lys Cys Ser 
1               5                   10                  15      


Gln Cys His Xaa Val Glu Lys Gly Gly Lys His Lys Xaa Gly Pro Asn 
            20                  25                  30          


Leu His Gly Leu Phe Gly Arg Lys Xaa Gly Gln Ala Pro Gly Tyr Ser 
        35                  40                  45              


Tyr Xaa Ala Ala Asn Lys Asn Lys Gly Ile Ile Trp Gly Glu Asp Xaa 
    50                  55                  60                  


Leu Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Xaa Lys 
65                  70                  75                  80  


Met Ile Phe Val Gly Ile Lys Lys Lys Glu Glu Arg Ala Asp Leu Ile 
                85                  90                  95      


Ala Tyr Leu Lys Lys 
            100     


<210> 7425
<211> 105
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<400> 7425
Met Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Ile Met Lys Cys Ser 
1               5                   10                  15      


Gln Cys His Xaa Val Glu Lys Gly Gly Lys His Lys Xaa Gly Pro Asn 
            20                  25                  30          


Leu His Gly Leu Phe Gly Arg Lys Xaa Gly Gln Ala Pro Gly Tyr Ser 
        35                  40                  45              


Tyr Xaa Ala Ala Asn Lys Asn Lys Gly Ile Ile Trp Gly Glu Asp Xaa 
    50                  55                  60                  


Leu Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Xaa Lys 
65                  70                  75                  80  


Met Ile Phe Val Gly Ile Lys Lys Lys Glu Glu Arg Ala Asp Leu Ile 
                85                  90                  95      


Ala Tyr Leu Lys Lys Ala Xaa Asn Glu 
            100                 105 


<210> 7426
<211> 77
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<400> 7426
Met Ala Ala Gln Val Xaa Leu Glu Asp Ala Leu Ser Asn Val Asp Leu 
1               5                   10                  15      


Leu Glu Glu Leu Pro Leu Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro 
            20                  25                  30          


Pro Ser Ser Leu Leu Tyr Gln Pro Asn Phe Asn Xaa Asn Phe Glu Asp 
        35                  40                  45              


Arg Asn Ala Phe Val Xaa Gly Ile Ala Arg Tyr Ile Glu Gln Ala Xaa 
    50                  55                  60                  


Val His Ser Ser Met Cys Lys Asn Asn Xaa Cys Trp Phe 
65                  70                  75          


<210> 7427
<211> 151
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<400> 7427
Met Ala Ala Gln Val Xaa Leu Glu Asp Ala Leu Ser Asn Val Asp Leu 
1               5                   10                  15      


Leu Glu Glu Leu Pro Leu Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro 
            20                  25                  30          


Pro Ser Ser Leu Leu Tyr Gln Pro Asn Phe Asn Xaa Asn Phe Glu Asp 
        35                  40                  45              


Arg Asn Ala Phe Val Xaa Gly Ile Ala Arg Tyr Ile Glu Gln Ala Xaa 
    50                  55                  60                  


Val His Ser Ser Met Asn Glu Met Leu Glu Glu Gly Gln Glu Tyr Ala 
65                  70                  75                  80  


Val Met Leu Tyr Xaa Trp Arg Ser Cys Ser Arg Ala Ile Pro Gln Val 
                85                  90                  95      


Lys Cys Asn Glu Gln Pro Asn Arg Val Glu Ile Tyr Glu Lys Xaa Val 
            100                 105                 110         


Glu Val Leu Glu Pro Glu Val Xaa Lys Leu Met Asn Phe Met Tyr Phe 
        115                 120                 125             


Gln Arg Asn Ala Ile Glu Arg Phe Cys Gly Glu Val Arg Arg Leu Cys 
    130                 135                 140                 


His Ala Glu Arg Arg Lys Asp 
145                 150     


<210> 7428
<211> 161
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<400> 7428
Met Ala Ala Gln Val Xaa Leu Glu Asp Ala Leu Ser Asn Val Asp Leu 
1               5                   10                  15      


Leu Glu Glu Leu Pro Leu Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro 
            20                  25                  30          


Pro Ser Ser Leu Leu Tyr Gln Pro Asn Phe Asn Xaa Asn Phe Glu Asp 
        35                  40                  45              


Arg Asn Ala Phe Val Xaa Gly Ile Ala Arg Tyr Ile Glu Gln Ala Xaa 
    50                  55                  60                  


Val His Ser Ser Met Asn Glu Met Leu Glu Glu Gly Gln Glu Tyr Ala 
65                  70                  75                  80  


Val Met Leu Tyr Xaa Trp Arg Ser Cys Ser Arg Ala Ile Pro Gln Val 
                85                  90                  95      


Lys Cys Asn Glu Gln Pro Asn Arg Val Glu Ile Tyr Glu Lys Xaa Val 
            100                 105                 110         


Glu Val Leu Glu Pro Glu Val Xaa Lys Leu Met Asn Phe Met Tyr Phe 
        115                 120                 125             


Gln Arg Asn Ala Ile Glu Arg Phe Cys Gly Glu Val Arg Arg Leu Cys 
    130                 135                 140                 


His Ala Glu Arg Arg Lys Asp Phe Val Ser Glu Ala Tyr Leu Ile Xaa 
145                 150                 155                 160 


Leu 
    


<210> 7429
<211> 1253
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1082)..(1082)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1144)..(1144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1148)..(1148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1220)..(1220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1234)..(1234)
<223> Selenocysteine

<400> 7429
Met Ala Ala Gln Val Xaa Leu Glu Asp Ala Leu Ser Asn Val Asp Leu 
1               5                   10                  15      


Leu Glu Glu Leu Pro Leu Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro 
            20                  25                  30          


Pro Ser Ser Leu Leu Tyr Gln Pro Asn Phe Asn Xaa Asn Phe Glu Asp 
        35                  40                  45              


Arg Asn Ala Phe Val Xaa Gly Ile Ala Arg Tyr Ile Glu Gln Ala Xaa 
    50                  55                  60                  


Val His Ser Ser Met Asn Glu Met Leu Glu Glu Gly Gln Glu Tyr Ala 
65                  70                  75                  80  


Val Met Leu Tyr Xaa Trp Arg Ser Cys Ser Arg Ala Ile Pro Gln Val 
                85                  90                  95      


Lys Cys Asn Glu Gln Pro Asn Arg Val Glu Ile Tyr Glu Lys Xaa Val 
            100                 105                 110         


Glu Val Leu Glu Pro Glu Val Xaa Lys Leu Met Asn Phe Met Tyr Phe 
        115                 120                 125             


Gln Arg Asn Ala Ile Glu Arg Phe Cys Gly Glu Val Arg Arg Leu Cys 
    130                 135                 140                 


His Ala Glu Arg Arg Lys Asp Phe Val Ser Glu Ala Tyr Leu Ile Xaa 
145                 150                 155                 160 


Leu Gly Lys Phe Ile Asn Met Phe Ala Val Leu Asp Glu Leu Lys Asn 
                165                 170                 175     


Met Lys Cys Ser Val Lys Asn Asp His Ser Ala Tyr Lys Arg Ala Ala 
            180                 185                 190         


Gln Phe Leu Arg Lys Met Ala Asp Pro Gln Ser Ile Gln Glu Ser Gln 
        195                 200                 205             


Asn Leu Ser Met Phe Leu Ala Asn His Asn Lys Ile Xaa Gln Ser Leu 
    210                 215                 220                 


Gln Gln Gln Leu Glu Val Ile Ser Gly Tyr Glu Glu Leu Leu Ala Asp 
225                 230                 235                 240 


Ile Val Asn Leu Cys Val Asp Tyr Tyr Glu Asn Arg Met Tyr Leu Xaa 
                245                 250                 255     


Pro Ser Glu Lys His Met Leu Leu Lys Val Met Gly Phe Gly Leu Tyr 
            260                 265                 270         


Leu Met Asp Gly Ser Val Ser Asn Ile Tyr Lys Leu Asp Ala Lys Lys 
        275                 280                 285             


Arg Ile Asn Leu Ser Lys Ile Asp Lys Tyr Phe Lys Gln Leu Gln Val 
    290                 295                 300                 


Val Pro Leu Phe Gly Asp Met Gln Ile Glu Leu Ala Arg Tyr Ile Lys 
305                 310                 315                 320 


Xaa Ser Ala His Tyr Glu Glu Asn Lys Ser Arg Trp Xaa Cys Xaa Ser 
                325                 330                 335     


Ser Gly Ser Ser Pro Gln Tyr Asn Ile Cys Glu Gln Met Ile Gln Ile 
            340                 345                 350         


Arg Glu Asp His Met Arg Phe Ile Ser Glu Leu Ala Arg Tyr Ser Asn 
        355                 360                 365             


Ser Glu Val Val Xaa Gly Ser Gly Arg Gln Glu Ala Gln Lys Xaa Asp 
    370                 375                 380                 


Ala Glu Tyr Arg Lys Leu Phe Asp Leu Ala Leu Gln Gly Leu Gln Leu 
385                 390                 395                 400 


Leu Ser Gln Trp Ser Ala His Val Met Glu Val Tyr Ser Trp Lys Leu 
                405                 410                 415     


Val His Pro Xaa Asp Lys Tyr Ser Asn Lys Asp Cys Pro Asp Ser Ala 
            420                 425                 430         


Glu Glu Tyr Glu Arg Ala Xaa Arg Tyr Asn Tyr Xaa Ser Glu Glu Lys 
        435                 440                 445             


Phe Ala Leu Val Glu Val Ile Ala Met Ile Lys Gly Leu Gln Val Leu 
    450                 455                 460                 


Met Gly Arg Met Glu Ser Val Phe Asn His Ala Ile Arg His Xaa Val 
465                 470                 475                 480 


Tyr Ala Ala Leu Gln Asp Phe Ser Gln Val Xaa Leu Arg Glu Pro Leu 
                485                 490                 495     


Arg Gln Ala Ile Lys Lys Lys Lys Asn Val Ile Gln Ser Val Leu Gln 
            500                 505                 510         


Ala Ile Arg Lys Xaa Val Cys Asp Trp Glu Xaa Gly His Glu Pro Phe 
        515                 520                 525             


Asn Asp Pro Ala Leu Arg Gly Glu Lys Asp Pro Lys Ser Gly Phe Asp 
    530                 535                 540                 


Ile Lys Val Pro Arg Arg Ala Val Gly Pro Ser Ser Xaa Gln Leu Tyr 
545                 550                 555                 560 


Met Val Arg Xaa Met Leu Glu Ser Leu Ile Ala Asp Lys Ser Gly Ser 
                565                 570                 575     


Lys Lys Xaa Leu Arg Ser Ser Leu Glu Gly Pro Xaa Ile Leu Asp Ile 
            580                 585                 590         


Glu Lys Phe His Arg Glu Ser Phe Phe Tyr Xaa His Leu Ile Asn Phe 
        595                 600                 605             


Ser Glu Xaa Leu Gln Gln Cys Cys Asp Leu Ser Gln Leu Trp Phe Arg 
    610                 615                 620                 


Glu Phe Phe Leu Glu Leu Xaa Met Gly Arg Arg Ile Gln Phe Pro Ile 
625                 630                 635                 640 


Glu Met Ser Met Pro Trp Ile Leu Xaa Asp His Ile Leu Glu Xaa Lys 
                645                 650                 655     


Glu Ala Ser Met Met Glu Tyr Val Leu Tyr Ser Leu Asp Leu Tyr Asn 
            660                 665                 670         


Asp Ser Ala His Tyr Ala Leu Xaa Arg Phe Asn Lys Gln Phe Leu Tyr 
        675                 680                 685             


Asp Glu Ile Glu Ala Glu Val Asn Leu Cys Phe Asp Gln Phe Val Tyr 
    690                 695                 700                 


Lys Leu Ala Asp Gln Ile Phe Ala Tyr Tyr Lys Val Met Ala Gly Ser 
705                 710                 715                 720 


Leu Leu Leu Asp Lys Arg Leu Arg Ser Glu Cys Lys Asn Gln Gly Ala 
                725                 730                 735     


Xaa Ile His Leu Pro Pro Ser Asn Arg Tyr Glu Xaa Leu Leu Lys Gln 
            740                 745                 750         


Arg His Val Gln Leu Leu Gly Arg Ser Ile Asp Leu Asn Arg Leu Ile 
        755                 760                 765             


Xaa Gln Arg Val Ser Ala Ala Met Tyr Lys Ser Leu Glu Leu Ala Ile 
    770                 775                 780                 


Gly Arg Phe Glu Ser Glu Asp Leu Xaa Ser Ile Val Glu Leu Asp Gly 
785                 790                 795                 800 


Leu Leu Glu Ile Asn Arg Met Xaa His Lys Leu Leu Ser Arg Tyr Leu 
                805                 810                 815     


Xaa Leu Asp Gly Phe Asp Ala Met Phe Arg Glu Ala Asn His Asn Val 
            820                 825                 830         


Ser Ala Pro Tyr Gly Arg Ile Xaa Leu His Val Phe Trp Glu Leu Asn 
        835                 840                 845             


Tyr Asp Phe Leu Pro Asn Tyr Cys Tyr Asn Gly Ser Xaa Asn Arg Phe 
    850                 855                 860                 


Val Arg Xaa Val Leu Pro Phe Ser Gln Glu Phe Gln Arg Asp Lys Gln 
865                 870                 875                 880 


Pro Asn Ala Gln Pro Gln Tyr Leu His Gly Ser Lys Ala Leu Asn Leu 
                885                 890                 895     


Ala Tyr Ser Ser Ile Tyr Gly Ser Tyr Arg Asn Phe Val Gly Pro Pro 
            900                 905                 910         


His Phe Gln Val Ile Cys Arg Leu Leu Gly Tyr Gln Gly Ile Ala Val 
        915                 920                 925             


Val Met Glu Glu Leu Leu Lys Val Val Lys Ser Leu Leu Gln Gly Xaa 
    930                 935                 940                 


Ile Leu Gln Tyr Val Lys Xaa Leu Met Glu Val Met Pro Lys Ile Cys 
945                 950                 955                 960 


Arg Leu Pro Arg His Glu Tyr Gly Ser Pro Gly Ile Leu Glu Phe Phe 
                965                 970                 975     


His His Gln Leu Lys Asp Ile Val Glu Tyr Ala Glu Leu Lys Xaa Val 
            980                 985                 990         


Cys Phe Gln Asn Leu Arg Glu Val  Gly Asn Ala Ile Leu  Phe Cys Leu 
        995                 1000                 1005             


Leu Ile  Glu Gln Ser Leu Ser  Leu Glu Glu Val Cys  Asp Leu Leu 
    1010                 1015                 1020             


His Ala  Ala Pro Phe Gln Asn  Ile Leu Pro Arg Val  His Val Lys 
    1025                 1030                 1035             


Glu Gly  Glu Arg Leu Asp Ala  Lys Met Lys Arg Leu  Glu Ser Lys 
    1040                 1045                 1050             


Tyr Ala  Pro Leu His Leu Val  Pro Leu Ile Glu Arg  Leu Gly Xaa 
    1055                 1060                 1065             


Pro Gln  Gln Ile Ala Ile Ala  Arg Glu Gly Asp Leu  Leu Xaa Lys 
    1070                 1075                 1080             


Glu Arg  Leu Cys Cys Gly Leu  Ser Met Phe Glu Val  Ile Leu Xaa 
    1085                 1090                 1095             


Arg Ile  Arg Ser Phe Leu Asp  Asp Pro Ile Trp Arg  Gly Pro Leu 
    1100                 1105                 1110             


Pro Ser  Asn Gly Val Met His  Val Asp Glu Cys Val  Glu Phe His 
    1115                 1120                 1125             


Arg Leu  Trp Ser Ala Met Gln  Phe Val Tyr Cys Ile  Pro Val Gly 
    1130                 1135                 1140             


Xaa His  Glu Phe Xaa Val Glu  Gln Cys Phe Gly Asp  Gly Leu His 
    1145                 1150                 1155             


Trp Ala  Gly Cys Met Ile Ile  Val Leu Leu Gly Gln  Gln Arg Arg 
    1160                 1165                 1170             


Phe Ala  Val Leu Asp Phe Cys  Tyr His Leu Leu Lys  Val Gln Lys 
    1175                 1180                 1185             


His Asp  Gly Lys Asp Glu Ile  Ile Lys Asn Val Pro  Leu Lys Lys 
    1190                 1195                 1200             


Met Val  Glu Arg Ile Arg Lys  Phe Gln Ile Leu Asn  Asp Glu Ile 
    1205                 1210                 1215             


Ile Xaa  Ile Leu Asp Lys Tyr  Leu Lys Ser Gly Asp  Gly Glu Gly 
    1220                 1225                 1230             


Xaa Pro  Val Glu His Val Arg  Cys Phe Gln Pro Pro  Ile His Gln 
    1235                 1240                 1245             


Ser Leu  Ala Ser Ser 
    1250             


<210> 7430
<211> 822
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (667)..(667)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(713)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (803)..(803)
<223> Selenocysteine

<400> 7430
Met Ala Glu Ser Leu Gly Ser Ala Glu Leu Leu Arg Gln Leu Lys Ser 
1               5                   10                  15      


Leu Gly Met Glu Arg Leu Leu His Ala Val Asn Xaa Phe Leu Arg Gln 
            20                  25                  30          


Ser Cys Xaa Tyr Leu Pro Leu Leu Xaa Phe Gly Gly Lys Xaa Ser Phe 
        35                  40                  45              


Val Ser Leu Asp Val Tyr Gly Xaa Glu Ala Asn Cys Ser Ala Xaa Ser 
    50                  55                  60                  


Cys Ser Phe Pro Lys Ala Ala Ala Xaa Trp Pro Arg Arg Gln Ala Pro 
65                  70                  75                  80  


Gly Pro Leu Gly Glu Leu Val Arg Gly Pro Pro Asp Gln Gly Val Ala 
                85                  90                  95      


Glu Gln Ser Phe Ser His Gly Leu Phe Glu Phe Gly Ile Xaa Asn Val 
            100                 105                 110         


Pro Cys Ile Phe Ser Pro Pro Gln Met Phe Pro Trp Ile Ile Gln Leu 
        115                 120                 125             


Tyr Met Val Arg Xaa Met Leu Glu Ser Leu Ile Ala Asp Lys Ser Gly 
    130                 135                 140                 


Ser Lys Lys Xaa Leu Arg Ser Ser Leu Glu Gly Pro Xaa Ile Leu Asp 
145                 150                 155                 160 


Ile Glu Lys Phe His Arg Glu Ser Phe Phe Tyr Xaa His Leu Ile Asn 
                165                 170                 175     


Phe Ser Glu Xaa Leu Gln Gln Cys Cys Asp Leu Ser Gln Leu Trp Phe 
            180                 185                 190         


Arg Glu Phe Phe Leu Glu Leu Xaa Met Gly Arg Arg Ile Gln Phe Pro 
        195                 200                 205             


Ile Glu Met Ser Met Pro Trp Ile Leu Xaa Asp His Ile Leu Glu Xaa 
    210                 215                 220                 


Lys Glu Ala Ser Met Met Glu Tyr Val Leu Tyr Ser Leu Asp Leu Tyr 
225                 230                 235                 240 


Asn Asp Ser Ala His Tyr Ala Leu Xaa Arg Phe Asn Lys Gln Phe Leu 
                245                 250                 255     


Tyr Asp Glu Ile Glu Ala Glu Val Asn Leu Cys Phe Asp Gln Phe Val 
            260                 265                 270         


Tyr Lys Leu Ala Asp Gln Ile Phe Ala Tyr Tyr Lys Val Met Ala Gly 
        275                 280                 285             


Ser Leu Leu Leu Asp Lys Arg Leu Arg Ser Glu Cys Lys Asn Gln Gly 
    290                 295                 300                 


Ala Xaa Ile His Leu Pro Pro Ser Asn Arg Tyr Glu Xaa Leu Leu Lys 
305                 310                 315                 320 


Gln Arg His Val Gln Leu Leu Gly Arg Ser Ile Asp Leu Asn Arg Leu 
                325                 330                 335     


Ile Xaa Gln Arg Val Ser Ala Ala Met Tyr Lys Ser Leu Glu Leu Ala 
            340                 345                 350         


Ile Gly Arg Phe Glu Ser Glu Asp Leu Xaa Ser Ile Val Glu Leu Asp 
        355                 360                 365             


Gly Leu Leu Glu Ile Asn Arg Met Xaa His Lys Leu Leu Ser Arg Tyr 
    370                 375                 380                 


Leu Xaa Leu Asp Gly Phe Asp Ala Met Phe Arg Glu Ala Asn His Asn 
385                 390                 395                 400 


Val Ser Ala Pro Tyr Gly Arg Ile Xaa Leu His Val Phe Trp Glu Leu 
                405                 410                 415     


Asn Tyr Asp Phe Leu Pro Asn Tyr Cys Tyr Asn Gly Ser Xaa Asn Arg 
            420                 425                 430         


Phe Val Arg Xaa Val Leu Pro Phe Ser Gln Glu Phe Gln Arg Asp Lys 
        435                 440                 445             


Gln Pro Asn Ala Gln Pro Gln Tyr Leu His Gly Ser Lys Ala Leu Asn 
    450                 455                 460                 


Leu Ala Tyr Ser Ser Ile Tyr Gly Ser Tyr Arg Asn Phe Val Gly Pro 
465                 470                 475                 480 


Pro His Phe Gln Val Ile Cys Arg Leu Leu Gly Tyr Gln Gly Ile Ala 
                485                 490                 495     


Val Val Met Glu Glu Leu Leu Lys Val Val Lys Ser Leu Leu Gln Gly 
            500                 505                 510         


Xaa Ile Leu Gln Tyr Val Lys Xaa Leu Met Glu Val Met Pro Lys Ile 
        515                 520                 525             


Cys Arg Leu Pro Arg His Glu Tyr Gly Ser Pro Gly Ile Leu Glu Phe 
    530                 535                 540                 


Phe His His Gln Leu Lys Asp Ile Val Glu Tyr Ala Glu Leu Lys Xaa 
545                 550                 555                 560 


Val Cys Phe Gln Asn Leu Arg Glu Val Gly Asn Ala Ile Leu Phe Cys 
                565                 570                 575     


Leu Leu Ile Glu Gln Ser Leu Ser Leu Glu Glu Val Cys Asp Leu Leu 
            580                 585                 590         


His Ala Ala Pro Phe Gln Asn Ile Leu Pro Arg Val His Val Lys Glu 
        595                 600                 605             


Gly Glu Arg Leu Asp Ala Lys Met Lys Arg Leu Glu Ser Lys Tyr Ala 
    610                 615                 620                 


Pro Leu His Leu Val Pro Leu Ile Glu Arg Leu Gly Xaa Pro Gln Gln 
625                 630                 635                 640 


Ile Ala Ile Ala Arg Glu Gly Asp Leu Leu Xaa Lys Glu Arg Leu Cys 
                645                 650                 655     


Cys Gly Leu Ser Met Phe Glu Val Ile Leu Xaa Arg Ile Arg Ser Phe 
            660                 665                 670         


Leu Asp Asp Pro Ile Trp Arg Gly Pro Leu Pro Ser Asn Gly Val Met 
        675                 680                 685             


His Val Asp Glu Cys Val Glu Phe His Arg Leu Trp Ser Ala Met Gln 
    690                 695                 700                 


Phe Val Tyr Cys Ile Pro Val Gly Xaa His Glu Phe Xaa Val Glu Gln 
705                 710                 715                 720 


Cys Phe Gly Asp Gly Leu His Trp Ala Gly Cys Met Ile Ile Val Leu 
                725                 730                 735     


Leu Gly Gln Gln Arg Arg Phe Ala Val Leu Asp Phe Cys Tyr His Leu 
            740                 745                 750         


Leu Lys Val Gln Lys His Asp Gly Lys Asp Glu Ile Ile Lys Asn Val 
        755                 760                 765             


Pro Leu Lys Lys Met Val Glu Arg Ile Arg Lys Phe Gln Ile Leu Asn 
    770                 775                 780                 


Asp Glu Ile Ile Xaa Ile Leu Asp Lys Tyr Leu Lys Ser Gly Asp Gly 
785                 790                 795                 800 


Glu Gly Xaa Pro Val Glu His Val Arg Cys Phe Gln Pro Pro Ile His 
                805                 810                 815     


Gln Ser Leu Ala Ser Ser 
            820         


<210> 7431
<211> 176
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (42)..(42)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<400> 7431
Pro Phe Gln Asn Ile Leu Pro Arg Val His Val Lys Glu Gly Glu Arg 
1               5                   10                  15      


Leu Asp Ala Lys Met Lys Arg Leu Glu Ser Lys Tyr Ala Pro Leu His 
            20                  25                  30          


Leu Val Pro Leu Ile Glu Arg Leu Gly Xaa Pro Gln Gln Ile Ala Ile 
        35                  40                  45              


Ala Arg Glu Gly Asp Leu Leu Xaa Lys Glu Arg Leu Cys Cys Gly Leu 
    50                  55                  60                  


Ser Met Phe Glu Val Ile Leu Xaa Arg Ile Arg Ser Phe Leu Asp Asp 
65                  70                  75                  80  


Pro Ile Trp Arg Gly Pro Leu Pro Ser Asn Gly Val Met His Val Asp 
                85                  90                  95      


Glu Cys Val Glu Phe His Arg Leu Trp Ser Ala Met Gln Phe Val Tyr 
            100                 105                 110         


Cys Ile Pro Val Gly Xaa His Glu Phe Xaa Val Glu Gln Cys Phe Gly 
        115                 120                 125             


Asp Gly Leu His Trp Ala Gly Cys Met Ile Ile Val Leu Leu Gly Gln 
    130                 135                 140                 


Gln Arg Arg Phe Ala Val Leu Asp Phe Cys Tyr His Leu Leu Lys Val 
145                 150                 155                 160 


Gln Lys His Asp Gly Lys Asp Glu Ile Ile Lys Asn Val Val Cys Gly 
                165                 170                 175     


<210> 7432
<211> 45
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<400> 7432
Xaa Cys Asp Trp Glu Xaa Gly His Glu Pro Phe Asn Asp Pro Ala Leu 
1               5                   10                  15      


Arg Gly Glu Lys Asp Pro Lys Ser Gly Phe Asp Ile Lys Val Pro Arg 
            20                  25                  30          


Arg Ala Val Gly Pro Ser Ser Xaa Gln Val Leu Val Pro 
        35                  40                  45  


<210> 7433
<211> 185
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<400> 7433
Xaa Tyr Xaa Ser Glu Glu Lys Phe Ala Leu Val Glu Val Ile Ala Met 
1               5                   10                  15      


Ile Lys Gly Leu Gln Val Leu Met Gly Arg Met Glu Ser Val Phe Asn 
            20                  25                  30          


His Ala Ile Arg His Xaa Val Tyr Ala Ala Leu Gln Asp Phe Ser Gln 
        35                  40                  45              


Val Xaa Leu Arg Glu Pro Leu Arg Gln Ala Ile Lys Lys Lys Lys Asn 
    50                  55                  60                  


Val Ile Gln Ser Val Leu Gln Ala Ile Arg Lys Xaa Val Cys Asp Trp 
65                  70                  75                  80  


Glu Xaa Gly His Glu Pro Phe Asn Asp Pro Ala Leu Arg Gly Glu Lys 
                85                  90                  95      


Asp Pro Lys Ser Gly Phe Asp Ile Lys Val Pro Arg Arg Ala Val Gly 
            100                 105                 110         


Pro Ser Ser Xaa Gln Leu Tyr Leu Val Arg Xaa Met Ala Glu Ser Leu 
        115                 120                 125             


Gly Ser Ala Glu Leu Leu Arg Gln Leu Lys Ser Leu Gly Met Glu Arg 
    130                 135                 140                 


Leu Leu His Ala Val Asn Xaa Phe Leu Arg Gln Ser Cys Xaa Tyr Leu 
145                 150                 155                 160 


Pro Leu Leu Xaa Phe Gly Glu Xaa Leu Gln Gln Cys Cys Asp Leu Ser 
                165                 170                 175     


Gln Leu Trp Phe Arg Glu Phe Phe Leu 
            180                 185 


<210> 7434
<211> 101
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<400> 7434
Leu Tyr Met Val Arg Xaa Met Leu Glu Ser Leu Ile Ala Asp Lys Ser 
1               5                   10                  15      


Gly Ser Lys Lys Xaa Leu Arg Ser Ser Leu Asp Gly Pro Ile Val Leu 
            20                  25                  30          


Ala Ile Glu Asp Phe His Lys Gln Ser Phe Phe Phe Xaa His Leu Leu 
        35                  40                  45              


Asn Ile Ser Asp Gly Val Leu Leu Cys Cys Pro Gly Trp Ser Ala Val 
    50                  55                  60                  


Ala Leu Ser Gln Leu Xaa Ala Xaa Ser Ala Ser Gln Val Gln Ala Gly 
65                  70                  75                  80  


Val Gln Ser Cys Asp Leu Ser Ser Pro Gln Pro Leu Pro Pro Arg Ser 
                85                  90                  95      


Pro Ala Ala Val Leu 
            100     


<210> 7435
<211> 71
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<400> 7435
Met Xaa Xaa His Val Xaa Leu Glu Asp Ala Leu Ser Asn Val Asp Leu 
1               5                   10                  15      


Leu Glu Glu Leu Pro Leu Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro 
            20                  25                  30          


Pro Ser Ser Ile Met Tyr Gln Ala Asn Phe Asp Xaa Asn Phe Glu Asp 
        35                  40                  45              


Arg Asn Ala Phe Val Xaa Gly Ile Ala Arg Tyr Ile Glu Gln Ala Xaa 
    50                  55                  60                  


Val His Ser Ser Met Ile Phe 
65                  70      


<210> 7436
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<400> 7436
Met Xaa Xaa His Val Xaa Leu Glu Asp Ala Leu Ser Asn Val Asp Leu 
1               5                   10                  15      


Leu Glu Glu Leu Pro Leu Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro 
            20                  25                  30          


Pro Ser Ser Ile Met Tyr Gln Ala Asn Phe Asp Xaa Asn Phe Glu Asp 
        35                  40                  45              


Arg Asn Ala Phe Val Xaa Gly Ile Ala Arg Tyr Ile Glu Gln Ala Xaa 
    50                  55                  60                  


Val His Ser Ser Met Asn Glu Met Leu Glu Glu Gly His Glu Tyr Ala 
65                  70                  75                  80  


Val Met Leu Tyr Xaa Trp Arg Ser Cys Ser Arg Ala Ile Pro Gln Val 
                85                  90                  95      


Lys Cys Asn Glu Gln Pro Asn Arg Val Glu Ile Tyr Glu Lys Xaa Val 
            100                 105                 110         


Glu Val Leu Glu Pro Glu Val Xaa Lys Leu Met Lys Phe Met Tyr Phe 
        115                 120                 125             


Gln Arg Lys Ala Ile Glu Arg Phe Cys Ser Glu Val Lys Arg Leu Cys 
    130                 135                 140                 


His Ala Glu Arg Arg Lys Asp Phe Val Ser Glu Ala Tyr Leu Leu Xaa 
145                 150                 155                 160 


Leu Gly Lys Phe Ile Asn Met Phe Ala Val Leu Asp Glu Leu Lys Asn 
                165                 170                 175     


Met Lys Cys Ser Val Lys Asn Asp His Ser Ala Tyr 
            180                 185             


<210> 7437
<211> 222
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<400> 7437
Met Xaa Xaa His Val Xaa Leu Glu Asp Ala Leu Ser Asn Val Asp Leu 
1               5                   10                  15      


Leu Glu Glu Leu Pro Leu Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro 
            20                  25                  30          


Pro Ser Ser Ile Met Tyr Gln Ala Asn Phe Asp Xaa Asn Phe Glu Asp 
        35                  40                  45              


Arg Asn Ala Phe Val Xaa Gly Ile Ala Arg Tyr Ile Glu Gln Ala Xaa 
    50                  55                  60                  


Val His Ser Ser Met Asn Glu Met Leu Glu Glu Gly His Glu Tyr Ala 
65                  70                  75                  80  


Val Met Leu Tyr Xaa Trp Arg Ser Cys Ser Arg Ala Ile Pro Gln Val 
                85                  90                  95      


Lys Cys Asn Glu Gln Pro Asn Arg Val Glu Ile Tyr Glu Lys Xaa Val 
            100                 105                 110         


Glu Val Leu Glu Pro Glu Val Xaa Lys Leu Met Lys Phe Met Tyr Phe 
        115                 120                 125             


Gln Arg Lys Ala Ile Glu Arg Phe Cys Ser Glu Val Lys Arg Leu Cys 
    130                 135                 140                 


His Ala Glu Arg Arg Lys Asp Phe Val Ser Glu Ala Tyr Leu Leu Xaa 
145                 150                 155                 160 


Leu Gly Lys Phe Ile Asn Met Phe Ala Val Leu Asp Glu Leu Lys Asn 
                165                 170                 175     


Met Lys Cys Ser Val Lys Asn Asp His Ser Ala Tyr Lys Arg Ala Ala 
            180                 185                 190         


Gln Phe Leu Arg Lys Met Ala Asp Pro Gln Ser Ile Gln Glu Ser Gln 
        195                 200                 205             


Asn Leu Ser Met Phe Leu Ala Asn His Asn Arg Ile Xaa Gln 
    210                 215                 220         


<210> 7438
<211> 1253
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (792)..(792)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(839)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (915)..(915)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (950)..(950)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (990)..(990)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1067)..(1067)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1081)..(1081)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1143)..(1143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1147)..(1147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1234)..(1234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1251)..(1252)
<223> Selenocysteine

<400> 7438
Met Xaa Xaa His Val Xaa Leu Glu Asp Ala Leu Ser Asn Val Asp Leu 
1               5                   10                  15      


Leu Glu Glu Leu Pro Leu Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro 
            20                  25                  30          


Pro Ser Ser Ile Met Tyr Gln Ala Asn Phe Asp Xaa Asn Phe Glu Asp 
        35                  40                  45              


Arg Asn Ala Phe Val Xaa Gly Ile Ala Arg Tyr Ile Glu Gln Ala Xaa 
    50                  55                  60                  


Val His Ser Ser Met Asn Glu Met Leu Glu Glu Gly His Glu Tyr Ala 
65                  70                  75                  80  


Val Met Leu Tyr Xaa Trp Arg Ser Cys Ser Arg Ala Ile Pro Gln Val 
                85                  90                  95      


Lys Cys Asn Glu Gln Pro Asn Arg Val Glu Ile Tyr Glu Lys Xaa Val 
            100                 105                 110         


Glu Val Leu Glu Pro Glu Val Xaa Lys Leu Met Lys Phe Met Tyr Phe 
        115                 120                 125             


Gln Arg Lys Ala Ile Glu Arg Phe Cys Ser Glu Val Lys Arg Leu Cys 
    130                 135                 140                 


His Ala Glu Arg Arg Lys Asp Phe Val Ser Glu Ala Tyr Leu Leu Xaa 
145                 150                 155                 160 


Leu Gly Lys Phe Ile Asn Met Phe Ala Val Leu Asp Glu Leu Lys Asn 
                165                 170                 175     


Met Lys Cys Ser Val Lys Asn Asp His Ser Ala Tyr Lys Arg Ala Ala 
            180                 185                 190         


Gln Phe Leu Arg Lys Met Ala Asp Pro Gln Ser Ile Gln Glu Ser Gln 
        195                 200                 205             


Asn Leu Ser Met Phe Leu Ala Asn His Asn Arg Ile Xaa Gln Cys Leu 
    210                 215                 220                 


His Gln Gln Leu Glu Val Ile Pro Gly Tyr Glu Glu Leu Leu Ala Asp 
225                 230                 235                 240 


Ile Val Asn Ile Cys Val Asp Tyr Tyr Glu Asn Lys Met Tyr Leu Xaa 
                245                 250                 255     


Pro Ser Glu Lys His Met Leu Leu Lys Val Met Gly Phe Gly Leu Tyr 
            260                 265                 270         


Leu Met Asp Gly Asn Val Ser Asn Ile Tyr Lys Leu Asp Ala Lys Lys 
        275                 280                 285             


Arg Ile Asn Leu Ser Lys Ile Asp Lys Phe Phe Lys Gln Leu Gln Val 
    290                 295                 300                 


Val Pro Leu Phe Gly Asp Met Gln Ile Glu Leu Ala Arg Tyr Ile Lys 
305                 310                 315                 320 


Xaa Ser Ala His Tyr Glu Glu Asn Lys Ser Lys Trp Xaa Cys Xaa Gln 
                325                 330                 335     


Ser Ser Ile Ser Pro Gln Tyr Asn Ile Cys Glu Gln Met Val Gln Ile 
            340                 345                 350         


Arg Asp Asp His Ile Arg Phe Ile Ser Glu Leu Ala Arg Tyr Ser Asn 
        355                 360                 365             


Ser Glu Val Val Xaa Gly Ser Gly Leu Asp Ser Gln Lys Ser Asp Glu 
    370                 375                 380                 


Glu Tyr Arg Glu Leu Phe Asp Leu Ala Leu Arg Gly Leu Gln Leu Leu 
385                 390                 395                 400 


Ser Lys Trp Ser Ala His Val Met Glu Val Tyr Ser Trp Lys Leu Val 
                405                 410                 415     


His Pro Xaa Asp Lys Phe Cys Asn Lys Asp Cys Pro Gly Xaa Ala Glu 
            420                 425                 430         


Glu Tyr Glu Arg Ala Xaa Arg Tyr Asn Tyr Xaa Ser Glu Glu Lys Phe 
        435                 440                 445             


Ala Phe Val Glu Val Ile Ala Met Ile Lys Gly Leu Gln Val Leu Met 
    450                 455                 460                 


Gly Arg Met Glu Ser Val Phe Asn Gln Ala Ile Arg Asn Xaa Ile Tyr 
465                 470                 475                 480 


Ala Ala Leu Gln Asp Phe Ala Gln Val Xaa Leu Arg Glu Pro Leu Arg 
                485                 490                 495     


Gln Ala Val Arg Lys Lys Lys Asn Val Leu Ile Ser Val Leu Gln Ala 
            500                 505                 510         


Ile Arg Lys Xaa Ile Cys Asp Trp Glu Gly Gly Arg Glu Pro Pro Asn 
        515                 520                 525             


Asp Pro Cys Leu Arg Gly Glu Lys Asp Pro Lys Gly Gly Phe Asp Ile 
    530                 535                 540                 


Lys Val Pro Arg Arg Ala Val Gly Pro Ser Ser Xaa Gln Leu Tyr Met 
545                 550                 555                 560 


Val Arg Xaa Met Leu Glu Ser Leu Ile Ala Asp Lys Ser Gly Ser Lys 
                565                 570                 575     


Lys Xaa Leu Arg Ser Ser Leu Asp Gly Pro Ile Val Leu Ala Ile Glu 
            580                 585                 590         


Asp Phe His Lys Gln Ser Phe Phe Phe Xaa His Leu Leu Asn Ile Ser 
        595                 600                 605             


Glu Ala Leu Gln Gln Cys Cys Asp Leu Ser Gln Leu Trp Phe Arg Glu 
    610                 615                 620                 


Phe Phe Leu Glu Leu Xaa Met Gly Arg Arg Ile Gln Phe Pro Ile Glu 
625                 630                 635                 640 


Met Ser Met Pro Trp Ile Leu Xaa Asp His Ile Leu Glu Xaa Lys Glu 
                645                 650                 655     


Pro Ser Met Met Glu Tyr Val Leu Tyr Pro Leu Asp Leu Tyr Asn Asp 
            660                 665                 670         


Ser Ala Tyr Tyr Ala Leu Xaa Lys Phe Lys Lys Gln Phe Leu Tyr Asp 
        675                 680                 685             


Glu Ile Glu Ala Glu Val Asn Leu Cys Phe Asp Gln Phe Val Tyr Lys 
    690                 695                 700                 


Leu Ala Asp Gln Ile Phe Ala Tyr Tyr Lys Ala Met Ala Gly Ser Val 
705                 710                 715                 720 


Leu Leu Asp Lys Arg Phe Arg Ala Glu Cys Lys Asn Tyr Gly Val Ile 
                725                 730                 735     


Ile Pro Tyr Pro Pro Ser Asn Arg Tyr Glu Xaa Leu Leu Lys Gln Arg 
            740                 745                 750         


His Val Gln Leu Leu Gly Arg Ser Ile Asp Leu Asn Arg Leu Ile Xaa 
        755                 760                 765             


Gln Arg Ile Ser Ala Ala Met Tyr Lys Ser Leu Asp Gln Ala Ile Ser 
    770                 775                 780                 


Arg Phe Glu Ser Glu Asp Leu Xaa Ser Ile Val Glu Leu Glu Trp Leu 
785                 790                 795                 800 


Leu Glu Ile Asn Arg Leu Xaa His Arg Leu Leu Cys Lys His Met Xaa 
                805                 810                 815     


Leu Asp Ser Phe Asp Ala Met Phe Arg Glu Ala Asn His Asn Val Ser 
            820                 825                 830         


Ala Pro Tyr Gly Arg Ile Xaa Leu His Val Phe Trp Glu Leu Asn Phe 
        835                 840                 845             


Asp Phe Leu Pro Asn Tyr Cys Tyr Asn Gly Ser Xaa Asn Arg Phe Val 
    850                 855                 860                 


Arg Xaa Ala Ile Pro Phe Xaa Gln Glu Pro Gln Arg Asp Lys Pro Ala 
865                 870                 875                 880 


Asn Val Gln Pro Tyr Tyr Leu Tyr Gly Ser Lys Pro Leu Asn Ile Ala 
                885                 890                 895     


Tyr Ser His Ile Tyr Ser Ser Tyr Arg Asn Phe Val Gly Pro Pro His 
            900                 905                 910         


Phe Lys Xaa Ile Cys Arg Leu Leu Gly Tyr Gln Gly Ile Ala Val Val 
        915                 920                 925             


Met Glu Glu Leu Leu Lys Ile Val Lys Ser Leu Leu Gln Gly Xaa Ile 
    930                 935                 940                 


Leu Gln Tyr Val Lys Xaa Leu Ile Glu Val Met Pro Lys Ile Cys Arg 
945                 950                 955                 960 


Leu Pro Arg His Glu Tyr Gly Ser Pro Gly Ile Leu Glu Phe Phe His 
                965                 970                 975     


His Gln Leu Lys Asp Ile Ile Glu Tyr Ala Glu Leu Lys Xaa Asp Val 
            980                 985                 990         


Phe Gln Ser Leu Arg Glu Val Gly  Asn Ala Ile Leu Phe  Cys Leu Leu 
        995                 1000                 1005             


Ile Glu  Gln Ala Leu Ser Gln  Glu Glu Val Cys Asp  Leu Leu His 
    1010                 1015                 1020             


Ala Ala  Pro Phe Gln Asn Ile  Leu Pro Arg Val Tyr  Ile Lys Glu 
    1025                 1030                 1035             


Gly Glu  Arg Leu Glu Val Arg  Met Lys Arg Leu Glu  Ala Lys Tyr 
    1040                 1045                 1050             


Ala Pro  Leu His Leu Val Pro  Leu Ile Glu Arg Leu  Gly Xaa Pro 
    1055                 1060                 1065             


Gln Gln  Ile Ala Ile Ala Arg  Glu Gly Asp Leu Leu  Xaa Lys Glu 
    1070                 1075                 1080             


Arg Leu  Cys Cys Gly Leu Ser  Met Phe Glu Val Ile  Leu Xaa Arg 
    1085                 1090                 1095             


Ile Arg  Ser Tyr Leu Gln Asp  Pro Ile Trp Arg Gly  Pro Pro Pro 
    1100                 1105                 1110             


Xaa Asn  Gly Val Met His Val  Asp Glu Cys Val Glu  Phe His Arg 
    1115                 1120                 1125             


Leu Trp  Ser Ala Met Gln Phe  Val Tyr Cys Ile Pro  Val Gly Xaa 
    1130                 1135                 1140             


Asn Glu  Phe Xaa Ala Glu Gln  Cys Phe Gly Asp Gly  Leu Asn Trp 
    1145                 1150                 1155             


Ala Gly  Cys Ser Ile Ile Val  Leu Leu Gly Gln Gln  Arg Arg Phe 
    1160                 1165                 1170             


Asp Leu  Phe Asp Phe Cys Tyr  His Leu Leu Lys Val  Gln Arg Gln 
    1175                 1180                 1185             


Asp Gly  Lys Asp Glu Ile Ile  Lys Asn Val Pro Leu  Lys Lys Met 
    1190                 1195                 1200             


Ala Asp  Arg Ile Arg Lys Tyr  Gln Ile Leu Asn Asn  Glu Val Phe 
    1205                 1210                 1215             


Ala Ile  Leu Asn Lys Tyr Met  Lys Ser Val Glu Xaa  Asp Ser Ser 
    1220                 1225                 1230             


Xaa Val  Glu His Val Arg Cys  Phe Gln Pro Pro Ile  His Gln Ser 
    1235                 1240                 1245             


Leu Ala  Xaa Xaa Cys 
    1250             


<210> 7439
<211> 1278
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (438)..(438)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (570)..(570)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (832)..(832)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (864)..(864)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (940)..(940)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (968)..(968)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1015)..(1015)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1092)..(1092)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1106)..(1106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1122)..(1122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1168)..(1168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1172)..(1172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1255)..(1255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1259)..(1259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1276)..(1277)
<223> Selenocysteine

<400> 7439
Met Xaa Xaa His Val Xaa Leu Glu Asp Ala Leu Ser Asn Val Asp Leu 
1               5                   10                  15      


Leu Glu Glu Leu Pro Leu Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro 
            20                  25                  30          


Pro Ser Ser Ile Met Tyr Gln Ala Asn Phe Asp Xaa Asn Phe Glu Asp 
        35                  40                  45              


Arg Asn Ala Phe Val Xaa Gly Ile Ala Arg Tyr Ile Glu Gln Ala Xaa 
    50                  55                  60                  


Val His Ser Ser Met Asn Glu Met Leu Glu Glu Gly His Glu Tyr Ala 
65                  70                  75                  80  


Val Met Leu Tyr Xaa Trp Arg Ser Cys Ser Arg Ala Ile Pro Gln Val 
                85                  90                  95      


Lys Cys Asn Glu Gln Pro Asn Arg Val Glu Ile Tyr Glu Lys Xaa Val 
            100                 105                 110         


Glu Val Leu Glu Pro Glu Val Xaa Lys Leu Met Lys Phe Met Tyr Phe 
        115                 120                 125             


Gln Arg Lys Ala Ile Glu Arg Phe Cys Ser Glu Val Lys Arg Leu Cys 
    130                 135                 140                 


His Ala Glu Arg Arg Lys Asp Phe Val Ser Glu Ala Tyr Leu Leu Xaa 
145                 150                 155                 160 


Leu Gly Lys Phe Ile Asn Met Phe Ala Val Leu Asp Glu Leu Lys Asn 
                165                 170                 175     


Met Lys Cys Ser Val Lys Asn Asp His Ser Ala Tyr Lys Arg Ala Ala 
            180                 185                 190         


Gln Phe Leu Arg Lys Met Ala Asp Pro Gln Ser Ile Gln Glu Ser Gln 
        195                 200                 205             


Asn Leu Ser Met Phe Leu Ala Asn His Asn Arg Ile Xaa Gln Cys Leu 
    210                 215                 220                 


His Gln Gln Leu Glu Val Ile Pro Gly Tyr Glu Glu Leu Leu Ala Asp 
225                 230                 235                 240 


Ile Val Asn Ile Cys Val Asp Tyr Tyr Glu Asn Lys Met Tyr Leu Xaa 
                245                 250                 255     


Pro Ser Glu Lys His Met Leu Leu Lys Val Met Gly Phe Gly Leu Tyr 
            260                 265                 270         


Leu Met Asp Gly Asn Val Ser Asn Ile Tyr Lys Leu Asp Ala Lys Lys 
        275                 280                 285             


Arg Ile Asn Leu Ser Lys Ile Asp Lys Phe Phe Lys Gln Leu Gln Val 
    290                 295                 300                 


Val Pro Leu Phe Gly Asp Met Gln Ile Glu Leu Ala Arg Tyr Ile Lys 
305                 310                 315                 320 


Xaa Ser Ala His Tyr Glu Glu Asn Lys Ser Lys Trp Xaa Cys Xaa Gln 
                325                 330                 335     


Ser Ser Ile Ser Pro Gln Tyr Asn Ile Cys Glu Gln Met Val Gln Ile 
            340                 345                 350         


Arg Asp Asp His Ile Arg Phe Ile Ser Glu Leu Ala Arg Tyr Ser Asn 
        355                 360                 365             


Ser Glu Val Val Xaa Gly Ser Gly Leu Asp Ser Gln Lys Ser Asp Glu 
    370                 375                 380                 


Glu Tyr Arg Glu Leu Phe Asp Leu Ala Leu Arg Gly Leu Gln Leu Leu 
385                 390                 395                 400 


Ser Lys Trp Ser Ala His Val Met Glu Val Tyr Ser Trp Lys Leu Val 
                405                 410                 415     


His Pro Xaa Asp Lys Phe Cys Asn Lys Asp Cys Pro Gly Xaa Ala Glu 
            420                 425                 430         


Glu Tyr Glu Arg Ala Xaa Arg Tyr Asn Tyr Xaa Ser Glu Glu Lys Phe 
        435                 440                 445             


Ala Phe Val Glu Val Ile Ala Met Ile Lys Gly Leu Gln Val Leu Met 
    450                 455                 460                 


Gly Arg Met Glu Ser Val Phe Asn Gln Ala Ile Arg Asn Xaa Ile Tyr 
465                 470                 475                 480 


Ala Ala Leu Gln Asp Phe Ala Gln Val Xaa Leu Arg Glu Pro Leu Arg 
                485                 490                 495     


Gln Ala Val Arg Lys Lys Lys Asn Val Leu Ile Ser Val Leu Gln Ala 
            500                 505                 510         


Ile Arg Lys Xaa Ile Cys Asp Trp Glu Gly Gly Arg Glu Pro Pro Asn 
        515                 520                 525             


Asp Pro Cys Leu Arg Gly Glu Lys Asp Pro Lys Gly Gly Phe Asp Ile 
    530                 535                 540                 


Lys Val Pro Arg Arg Ala Val Gly Pro Ser Ser Xaa Gln Ala Cys Gln 
545                 550                 555                 560 


Trp Ser Pro Arg Ala Leu Phe His Pro Xaa Gly Gly Xaa Gln Gly Arg 
                565                 570                 575     


Arg Gly Cys Arg Ser Leu Leu Tyr Met Val Arg Xaa Met Leu Glu Ser 
            580                 585                 590         


Leu Ile Ala Asp Lys Ser Gly Ser Lys Lys Xaa Leu Arg Ser Ser Leu 
        595                 600                 605             


Asp Gly Pro Ile Val Leu Ala Ile Glu Asp Phe His Lys Gln Ser Phe 
    610                 615                 620                 


Phe Phe Xaa His Leu Leu Asn Ile Ser Glu Ala Leu Gln Gln Cys Cys 
625                 630                 635                 640 


Asp Leu Ser Gln Leu Trp Phe Arg Glu Phe Phe Leu Glu Leu Xaa Met 
                645                 650                 655     


Gly Arg Arg Ile Gln Phe Pro Ile Glu Met Ser Met Pro Trp Ile Leu 
            660                 665                 670         


Xaa Asp His Ile Leu Glu Xaa Lys Glu Pro Ser Met Met Glu Tyr Val 
        675                 680                 685             


Leu Tyr Pro Leu Asp Leu Tyr Asn Asp Ser Ala Tyr Tyr Ala Leu Xaa 
    690                 695                 700                 


Lys Phe Lys Lys Gln Phe Leu Tyr Asp Glu Ile Glu Ala Glu Val Asn 
705                 710                 715                 720 


Leu Cys Phe Asp Gln Phe Val Tyr Lys Leu Ala Asp Gln Ile Phe Ala 
                725                 730                 735     


Tyr Tyr Lys Ala Met Ala Gly Ser Val Leu Leu Asp Lys Arg Phe Arg 
            740                 745                 750         


Ala Glu Cys Lys Asn Tyr Gly Val Ile Ile Pro Tyr Pro Pro Ser Asn 
        755                 760                 765             


Arg Tyr Glu Xaa Leu Leu Lys Gln Arg His Val Gln Leu Leu Gly Arg 
    770                 775                 780                 


Ser Ile Asp Leu Asn Arg Leu Ile Xaa Gln Arg Ile Ser Ala Ala Met 
785                 790                 795                 800 


Tyr Lys Ser Leu Asp Gln Ala Ile Ser Arg Phe Glu Ser Glu Asp Leu 
                805                 810                 815     


Xaa Ser Ile Val Glu Leu Glu Trp Leu Leu Glu Ile Asn Arg Leu Xaa 
            820                 825                 830         


His Arg Leu Leu Cys Lys His Met Xaa Leu Asp Ser Phe Asp Ala Met 
        835                 840                 845             


Phe Arg Glu Ala Asn His Asn Val Ser Ala Pro Tyr Gly Arg Ile Xaa 
    850                 855                 860                 


Leu His Val Phe Trp Glu Leu Asn Phe Asp Phe Leu Pro Asn Tyr Cys 
865                 870                 875                 880 


Tyr Asn Gly Ser Xaa Asn Arg Phe Val Arg Xaa Ala Ile Pro Phe Xaa 
                885                 890                 895     


Gln Glu Pro Gln Arg Asp Lys Pro Ala Asn Val Gln Pro Tyr Tyr Leu 
            900                 905                 910         


Tyr Gly Ser Lys Pro Leu Asn Ile Ala Tyr Ser His Ile Tyr Ser Ser 
        915                 920                 925             


Tyr Arg Asn Phe Val Gly Pro Pro His Phe Lys Xaa Ile Cys Arg Leu 
    930                 935                 940                 


Leu Gly Tyr Gln Gly Ile Ala Val Val Met Glu Glu Leu Leu Lys Ile 
945                 950                 955                 960 


Val Lys Ser Leu Leu Gln Gly Xaa Ile Leu Gln Tyr Val Lys Xaa Leu 
                965                 970                 975     


Ile Glu Val Met Pro Lys Ile Cys Arg Leu Pro Arg His Glu Tyr Gly 
            980                 985                 990         


Ser Pro Gly Ile Leu Glu Phe Phe  His His Gln Leu Lys  Asp Ile Ile 
        995                 1000                 1005             


Glu Tyr  Ala Glu Leu Lys Xaa  Asp Val Phe Gln Ser  Leu Arg Glu 
    1010                 1015                 1020             


Val Gly  Asn Ala Ile Leu Phe  Cys Leu Leu Ile Glu  Gln Ala Leu 
    1025                 1030                 1035             


Ser Gln  Glu Glu Val Cys Asp  Leu Leu His Ala Ala  Pro Phe Gln 
    1040                 1045                 1050             


Asn Ile  Leu Pro Arg Val Tyr  Ile Lys Glu Gly Glu  Arg Leu Glu 
    1055                 1060                 1065             


Val Arg  Met Lys Arg Leu Glu  Ala Lys Tyr Ala Pro  Leu His Leu 
    1070                 1075                 1080             


Val Pro  Leu Ile Glu Arg Leu  Gly Xaa Pro Gln Gln  Ile Ala Ile 
    1085                 1090                 1095             


Ala Arg  Glu Gly Asp Leu Leu  Xaa Lys Glu Arg Leu  Cys Cys Gly 
    1100                 1105                 1110             


Leu Ser  Met Phe Glu Val Ile  Leu Xaa Arg Ile Arg  Ser Tyr Leu 
    1115                 1120                 1125             


Gln Asp  Pro Ile Trp Arg Gly  Pro Pro Pro Xaa Asn  Gly Val Met 
    1130                 1135                 1140             


His Val  Asp Glu Cys Val Glu  Phe His Arg Leu Trp  Ser Ala Met 
    1145                 1150                 1155             


Gln Phe  Val Tyr Cys Ile Pro  Val Gly Xaa Asn Glu  Phe Xaa Ala 
    1160                 1165                 1170             


Glu Gln  Cys Phe Gly Asp Gly  Leu Asn Trp Ala Gly  Cys Ser Ile 
    1175                 1180                 1185             


Ile Val  Leu Leu Gly Gln Gln  Arg Arg Phe Asp Leu  Phe Asp Phe 
    1190                 1195                 1200             


Cys Tyr  His Leu Leu Lys Val  Gln Arg Gln Asp Gly  Lys Asp Glu 
    1205                 1210                 1215             


Ile Ile  Lys Asn Val Pro Leu  Lys Lys Met Ala Asp  Arg Ile Arg 
    1220                 1225                 1230             


Lys Tyr  Gln Ile Leu Asn Asn  Glu Val Phe Ala Ile  Leu Asn Lys 
    1235                 1240                 1245             


Tyr Met  Lys Ser Val Glu Xaa  Asp Ser Ser Xaa Val  Glu His Val 
    1250                 1255                 1260             


Arg Cys  Phe Gln Pro Pro Ile  His Gln Ser Leu Ala  Xaa Xaa Cys 
    1265                 1270                 1275             


<210> 7440
<211> 295
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<400> 7440
Met Xaa Xaa His Val Xaa Leu Glu Asp Ala Leu Ser Asn Val Asp Leu 
1               5                   10                  15      


Leu Glu Glu Leu Pro Leu Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro 
            20                  25                  30          


Pro Ser Ser Ile Met Tyr Gln Ala Asn Phe Asp Xaa Asn Phe Glu Asp 
        35                  40                  45              


Arg Asn Ala Phe Val Xaa Gly Ile Ala Arg Tyr Ile Glu Gln Ala Xaa 
    50                  55                  60                  


Val His Ser Ser Met Asn Glu Met Leu Glu Glu Gly His Glu Tyr Ala 
65                  70                  75                  80  


Val Met Leu Tyr Xaa Trp Arg Ser Cys Ser Arg Ala Ile Pro Gln Val 
                85                  90                  95      


Lys Cys Asn Glu Gln Pro Asn Arg Val Glu Ile Tyr Glu Lys Xaa Val 
            100                 105                 110         


Glu Val Leu Glu Pro Glu Val Xaa Lys Leu Met Lys Phe Met Tyr Phe 
        115                 120                 125             


Gln Arg Lys Ala Ile Glu Arg Phe Cys Ser Glu Val Lys Arg Leu Cys 
    130                 135                 140                 


His Ala Glu Arg Arg Lys Asp Phe Val Ser Glu Ala Tyr Leu Leu Xaa 
145                 150                 155                 160 


Leu Gly Lys Phe Ile Asn Met Phe Ala Val Leu Asp Glu Leu Lys Asn 
                165                 170                 175     


Met Lys Cys Ser Val Lys Asn Asp His Ser Ala Tyr Lys Arg Ala Ala 
            180                 185                 190         


Gln Phe Leu Arg Lys Met Ala Asp Pro Gln Ser Ile Gln Glu Ser Gln 
        195                 200                 205             


Asn Leu Ser Met Phe Leu Ala Asn His Asn Arg Ile Xaa Gln Gln Leu 
    210                 215                 220                 


Glu Val Ile Pro Gly Tyr Glu Glu Leu Leu Ala Asp Ile Val Asn Ile 
225                 230                 235                 240 


Cys Val Asp Tyr Tyr Glu Asn Lys Met Tyr Leu Xaa Pro Ser Glu Lys 
                245                 250                 255     


His Met Leu Leu Lys Val Met Gly Phe Gly Leu Tyr Leu Met Asp Gly 
            260                 265                 270         


Asn Val Ser Asn Ile Tyr Lys Leu Asp Ala Lys Lys Arg Ile Asn Leu 
        275                 280                 285             


Ser Lys Ile Asp Lys Phe Phe 
    290                 295 


<210> 7441
<211> 1117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (735)..(735)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (807)..(807)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (814)..(814)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (931)..(931)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (961)..(961)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1007)..(1007)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1011)..(1011)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1094)..(1094)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1115)..(1116)
<223> Selenocysteine

<400> 7441
Met Xaa Xaa His Val Xaa Leu Glu Asp Ala Leu Ser Asn Val Asp Leu 
1               5                   10                  15      


Leu Glu Glu Leu Pro Leu Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro 
            20                  25                  30          


Pro Ser Ser Ile Met Tyr Gln Ala Asn Phe Asp Xaa Asn Phe Glu Asp 
        35                  40                  45              


Arg Asn Ala Phe Val Xaa Gly Ile Ala Arg Tyr Ile Glu Gln Ala Xaa 
    50                  55                  60                  


Val His Ser Ser Met Asn Glu Met Leu Glu Glu Gly His Glu Tyr Ala 
65                  70                  75                  80  


Val Met Leu Tyr Xaa Trp Arg Ser Cys Ser Arg Ala Ile Pro Gln Val 
                85                  90                  95      


Lys Cys Asn Glu Gln Pro Asn Arg Val Glu Ile Tyr Glu Lys Xaa Val 
            100                 105                 110         


Glu Val Leu Glu Pro Glu Val Xaa Lys Leu Met Lys Phe Met Tyr Phe 
        115                 120                 125             


Gln Val Met Gly Phe Gly Leu Tyr Leu Met Asp Gly Asn Val Ser Asn 
    130                 135                 140                 


Ile Tyr Lys Leu Asp Ala Lys Lys Arg Ile Asn Leu Ser Lys Ile Asp 
145                 150                 155                 160 


Lys Phe Phe Lys Gln Leu Gln Val Val Pro Leu Phe Gly Asp Met Gln 
                165                 170                 175     


Ile Glu Leu Ala Arg Tyr Ile Lys Xaa Ser Ala His Tyr Glu Glu Asn 
            180                 185                 190         


Lys Ser Lys Trp Xaa Cys Xaa Gln Ser Ser Ile Ser Pro Gln Tyr Asn 
        195                 200                 205             


Ile Cys Glu Gln Met Val Gln Ile Arg Asp Asp His Ile Arg Phe Ile 
    210                 215                 220                 


Ser Glu Leu Ala Arg Tyr Ser Asn Ser Glu Val Val Xaa Gly Ser Gly 
225                 230                 235                 240 


Leu Asp Ser Gln Lys Ser Asp Glu Glu Tyr Arg Glu Leu Phe Asp Leu 
                245                 250                 255     


Ala Leu Arg Gly Leu Gln Leu Leu Ser Lys Trp Ser Ala His Val Met 
            260                 265                 270         


Glu Val Tyr Ser Trp Lys Leu Val His Pro Xaa Asp Lys Phe Cys Asn 
        275                 280                 285             


Lys Asp Cys Pro Gly Xaa Ala Glu Glu Tyr Glu Arg Ala Xaa Arg Tyr 
    290                 295                 300                 


Asn Tyr Xaa Ser Glu Glu Lys Phe Ala Phe Val Glu Val Ile Ala Met 
305                 310                 315                 320 


Ile Lys Gly Leu Gln Val Leu Met Gly Arg Met Glu Ser Val Phe Asn 
                325                 330                 335     


Gln Ala Ile Arg Asn Xaa Ile Tyr Ala Ala Leu Gln Asp Phe Ala Gln 
            340                 345                 350         


Val Xaa Leu Arg Glu Pro Leu Arg Gln Ala Val Arg Lys Lys Lys Asn 
        355                 360                 365             


Val Leu Ile Ser Val Leu Gln Ala Ile Arg Lys Xaa Ile Cys Asp Trp 
    370                 375                 380                 


Glu Gly Gly Arg Glu Pro Pro Asn Asp Pro Cys Leu Arg Gly Glu Lys 
385                 390                 395                 400 


Asp Pro Lys Gly Gly Phe Asp Ile Lys Val Pro Arg Arg Ala Val Gly 
                405                 410                 415     


Pro Ser Ser Xaa Gln Leu Tyr Met Val Arg Xaa Met Leu Glu Ser Leu 
            420                 425                 430         


Ile Ala Asp Lys Ser Gly Ser Lys Lys Xaa Leu Arg Ser Ser Leu Asp 
        435                 440                 445             


Gly Pro Ile Val Leu Ala Ile Glu Asp Phe His Lys Gln Ser Phe Phe 
    450                 455                 460                 


Phe Xaa His Leu Leu Asn Ile Ser Glu Ala Leu Gln Gln Cys Cys Asp 
465                 470                 475                 480 


Leu Ser Gln Leu Trp Phe Arg Glu Phe Phe Leu Glu Leu Xaa Met Gly 
                485                 490                 495     


Arg Arg Ile Gln Phe Pro Ile Glu Met Ser Met Pro Trp Ile Leu Xaa 
            500                 505                 510         


Asp His Ile Leu Glu Xaa Lys Glu Pro Ser Met Met Glu Tyr Val Leu 
        515                 520                 525             


Tyr Pro Leu Asp Leu Tyr Asn Asp Ser Ala Tyr Tyr Ala Leu Xaa Lys 
    530                 535                 540                 


Phe Lys Lys Gln Phe Leu Tyr Asp Glu Ile Glu Ala Glu Val Asn Leu 
545                 550                 555                 560 


Cys Phe Asp Gln Phe Val Tyr Lys Leu Ala Asp Gln Ile Phe Ala Tyr 
                565                 570                 575     


Tyr Lys Ala Met Ala Gly Ser Val Leu Leu Asp Lys Arg Phe Arg Ala 
            580                 585                 590         


Glu Cys Lys Asn Tyr Gly Val Ile Ile Pro Tyr Pro Pro Ser Asn Arg 
        595                 600                 605             


Tyr Glu Xaa Leu Leu Lys Gln Arg His Val Gln Leu Leu Gly Arg Ser 
    610                 615                 620                 


Ile Asp Leu Asn Arg Leu Ile Xaa Gln Arg Ile Ser Ala Ala Met Tyr 
625                 630                 635                 640 


Lys Ser Leu Asp Gln Ala Ile Ser Arg Phe Glu Ser Glu Asp Leu Xaa 
                645                 650                 655     


Ser Ile Val Glu Leu Glu Trp Leu Leu Glu Ile Asn Arg Leu Xaa His 
            660                 665                 670         


Arg Leu Leu Cys Lys His Met Xaa Leu Asp Ser Phe Asp Ala Met Phe 
        675                 680                 685             


Arg Glu Ala Asn His Asn Val Ser Ala Pro Tyr Gly Arg Ile Xaa Leu 
    690                 695                 700                 


His Val Phe Trp Glu Leu Asn Phe Asp Phe Leu Pro Asn Tyr Cys Tyr 
705                 710                 715                 720 


Asn Gly Ser Xaa Asn Arg Phe Val Arg Xaa Ala Ile Pro Phe Xaa Gln 
                725                 730                 735     


Glu Pro Gln Arg Asp Lys Pro Ala Asn Val Gln Pro Tyr Tyr Leu Tyr 
            740                 745                 750         


Gly Ser Lys Pro Leu Asn Ile Ala Tyr Ser His Ile Tyr Ser Ser Tyr 
        755                 760                 765             


Arg Asn Phe Val Gly Pro Pro His Phe Lys Xaa Ile Cys Arg Leu Leu 
    770                 775                 780                 


Gly Tyr Gln Gly Ile Ala Val Val Met Glu Glu Leu Leu Lys Ile Val 
785                 790                 795                 800 


Lys Ser Leu Leu Gln Gly Xaa Ile Leu Gln Tyr Val Lys Xaa Leu Ile 
                805                 810                 815     


Glu Val Met Pro Lys Ile Cys Arg Leu Pro Arg His Glu Tyr Gly Ser 
            820                 825                 830         


Pro Gly Ile Leu Glu Phe Phe His His Gln Leu Lys Asp Ile Ile Glu 
        835                 840                 845             


Tyr Ala Glu Leu Lys Xaa Asp Val Phe Gln Ser Leu Arg Glu Val Gly 
    850                 855                 860                 


Asn Ala Ile Leu Phe Cys Leu Leu Ile Glu Gln Ala Leu Ser Gln Glu 
865                 870                 875                 880 


Glu Val Cys Asp Leu Leu His Ala Ala Pro Phe Gln Asn Ile Leu Pro 
                885                 890                 895     


Arg Val Tyr Ile Lys Glu Gly Glu Arg Leu Glu Val Arg Met Lys Arg 
            900                 905                 910         


Leu Glu Ala Lys Tyr Ala Pro Leu His Leu Val Pro Leu Ile Glu Arg 
        915                 920                 925             


Leu Gly Xaa Pro Gln Gln Ile Ala Ile Ala Arg Glu Gly Asp Leu Leu 
    930                 935                 940                 


Xaa Lys Glu Arg Leu Cys Cys Gly Leu Ser Met Phe Glu Val Ile Leu 
945                 950                 955                 960 


Xaa Arg Ile Arg Ser Tyr Leu Gln Asp Pro Ile Trp Arg Gly Pro Pro 
                965                 970                 975     


Pro Xaa Asn Gly Val Met His Val Asp Glu Cys Val Glu Phe His Arg 
            980                 985                 990         


Leu Trp Ser Ala Met Gln Phe Val  Tyr Cys Ile Pro Val  Gly Xaa Asn 
        995                 1000                 1005             


Glu Phe  Xaa Ala Glu Gln Cys  Phe Gly Asp Gly Leu  Asn Trp Ala 
    1010                 1015                 1020             


Gly Cys  Ser Ile Ile Val Leu  Leu Gly Gln Gln Arg  Arg Phe Asp 
    1025                 1030                 1035             


Leu Phe  Asp Phe Cys Tyr His  Leu Leu Lys Val Gln  Arg Gln Asp 
    1040                 1045                 1050             


Gly Lys  Asp Glu Ile Ile Lys  Asn Val Pro Leu Lys  Lys Met Ala 
    1055                 1060                 1065             


Asp Arg  Ile Arg Lys Tyr Gln  Ile Leu Asn Asn Glu  Val Phe Ala 
    1070                 1075                 1080             


Ile Leu  Asn Lys Tyr Met Lys  Ser Val Glu Xaa Asp  Ser Ser Xaa 
    1085                 1090                 1095             


Val Glu  His Val Arg Cys Phe  Gln Pro Pro Ile His  Gln Ser Leu 
    1100                 1105                 1110             


Ala Xaa  Xaa Cys 
    1115         


<210> 7442
<211> 1227
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (134)..(134)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (628)..(628)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (742)..(742)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(834)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (840)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (889)..(889)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (964)..(964)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1071)..(1071)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1088)..(1088)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1117)..(1117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1121)..(1121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1204)..(1204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1208)..(1208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1226)
<223> Selenocysteine

<400> 7442
Met Xaa Xaa His Val Xaa Leu Glu Asp Ala Leu Ser Asn Val Asp Leu 
1               5                   10                  15      


Leu Glu Glu Leu Pro Leu Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro 
            20                  25                  30          


Pro Ser Ser Ile Met Tyr Gln Ala Asn Phe Asp Xaa Asn Phe Glu Asp 
        35                  40                  45              


Arg Asn Ala Phe Val Xaa Gly Ile Ala Arg Tyr Ile Glu Gln Ala Xaa 
    50                  55                  60                  


Val His Ser Ser Met Val Lys Cys Asn Glu Gln Pro Asn Arg Val Glu 
65                  70                  75                  80  


Ile Tyr Glu Lys Xaa Val Glu Val Leu Glu Pro Glu Val Xaa Lys Leu 
                85                  90                  95      


Met Lys Phe Met Tyr Phe Gln Arg Lys Ala Ile Glu Arg Phe Cys Ser 
            100                 105                 110         


Glu Val Lys Arg Leu Cys His Ala Glu Arg Arg Lys Asp Phe Val Ser 
        115                 120                 125             


Glu Ala Tyr Leu Leu Xaa Leu Gly Lys Phe Ile Asn Met Phe Ala Val 
    130                 135                 140                 


Leu Asp Glu Leu Lys Asn Met Lys Cys Ser Val Lys Asn Asp His Ser 
145                 150                 155                 160 


Ala Tyr Lys Arg Ala Ala Gln Phe Leu Arg Lys Met Ala Asp Pro Gln 
                165                 170                 175     


Ser Ile Gln Glu Ser Gln Asn Leu Ser Met Phe Leu Ala Asn His Asn 
            180                 185                 190         


Arg Ile Xaa Gln Cys Leu His Gln Gln Leu Glu Val Ile Pro Gly Tyr 
        195                 200                 205             


Glu Glu Leu Leu Ala Asp Ile Val Asn Ile Cys Val Asp Tyr Tyr Glu 
    210                 215                 220                 


Asn Lys Met Tyr Leu Xaa Pro Ser Glu Lys His Met Leu Leu Lys Val 
225                 230                 235                 240 


Met Gly Phe Gly Leu Tyr Leu Met Asp Gly Asn Val Ser Asn Ile Tyr 
                245                 250                 255     


Lys Leu Asp Ala Lys Lys Arg Ile Asn Leu Ser Lys Ile Asp Lys Phe 
            260                 265                 270         


Phe Lys Gln Leu Gln Val Val Pro Leu Phe Gly Asp Met Gln Ile Glu 
        275                 280                 285             


Leu Ala Arg Tyr Ile Lys Xaa Ser Ala His Tyr Glu Glu Asn Lys Ser 
    290                 295                 300                 


Lys Trp Xaa Cys Xaa Gln Ser Ser Ile Ser Pro Gln Tyr Asn Ile Cys 
305                 310                 315                 320 


Glu Gln Met Val Gln Ile Arg Asp Asp His Ile Arg Phe Ile Ser Glu 
                325                 330                 335     


Leu Ala Arg Tyr Ser Asn Ser Glu Val Val Xaa Gly Ser Gly Leu Asp 
            340                 345                 350         


Ser Gln Lys Ser Asp Glu Glu Tyr Arg Glu Leu Phe Asp Leu Ala Leu 
        355                 360                 365             


Arg Gly Leu Gln Leu Leu Ser Lys Trp Ser Ala His Val Met Glu Val 
    370                 375                 380                 


Tyr Ser Trp Lys Leu Val His Pro Xaa Asp Lys Phe Cys Asn Lys Asp 
385                 390                 395                 400 


Cys Pro Gly Xaa Ala Glu Glu Tyr Glu Arg Ala Xaa Arg Tyr Asn Tyr 
                405                 410                 415     


Xaa Ser Glu Glu Lys Phe Ala Phe Val Glu Val Ile Ala Met Ile Lys 
            420                 425                 430         


Gly Leu Gln Val Leu Met Gly Arg Met Glu Ser Val Phe Asn Gln Ala 
        435                 440                 445             


Ile Arg Asn Xaa Ile Tyr Ala Ala Leu Gln Asp Phe Ala Gln Val Xaa 
    450                 455                 460                 


Leu Arg Glu Pro Leu Arg Gln Ala Val Arg Lys Lys Lys Asn Val Leu 
465                 470                 475                 480 


Ile Ser Val Leu Gln Ala Ile Arg Lys Xaa Ile Cys Asp Trp Glu Gly 
                485                 490                 495     


Gly Arg Glu Pro Pro Asn Asp Pro Cys Leu Arg Gly Glu Lys Asp Pro 
            500                 505                 510         


Lys Gly Gly Phe Asp Ile Lys Val Pro Arg Arg Ala Val Gly Pro Ser 
        515                 520                 525             


Ser Xaa Gln Leu Tyr Met Val Arg Xaa Met Leu Glu Ser Leu Ile Ala 
    530                 535                 540                 


Asp Lys Ser Gly Ser Lys Lys Xaa Leu Arg Ser Ser Leu Asp Gly Pro 
545                 550                 555                 560 


Ile Val Leu Ala Ile Glu Asp Phe His Lys Gln Ser Phe Phe Phe Xaa 
                565                 570                 575     


His Leu Leu Asn Ile Ser Glu Ala Leu Gln Gln Cys Cys Asp Leu Ser 
            580                 585                 590         


Gln Leu Trp Phe Arg Glu Phe Phe Leu Glu Leu Xaa Met Gly Arg Arg 
        595                 600                 605             


Ile Gln Phe Pro Ile Glu Met Ser Met Pro Trp Ile Leu Xaa Asp His 
    610                 615                 620                 


Ile Leu Glu Xaa Lys Glu Pro Ser Met Met Glu Tyr Val Leu Tyr Pro 
625                 630                 635                 640 


Leu Asp Leu Tyr Asn Asp Ser Ala Tyr Tyr Ala Leu Xaa Lys Phe Lys 
                645                 650                 655     


Lys Gln Phe Leu Tyr Asp Glu Ile Glu Ala Glu Val Asn Leu Cys Phe 
            660                 665                 670         


Asp Gln Phe Val Tyr Lys Leu Ala Asp Gln Ile Phe Ala Tyr Tyr Lys 
        675                 680                 685             


Ala Met Ala Gly Ser Val Leu Leu Asp Lys Arg Phe Arg Ala Glu Cys 
    690                 695                 700                 


Lys Asn Tyr Gly Val Ile Ile Pro Tyr Pro Pro Ser Asn Arg Tyr Glu 
705                 710                 715                 720 


Xaa Leu Leu Lys Gln Arg His Val Gln Leu Leu Gly Arg Ser Ile Asp 
                725                 730                 735     


Leu Asn Arg Leu Ile Xaa Gln Arg Ile Ser Ala Ala Met Tyr Lys Ser 
            740                 745                 750         


Leu Asp Gln Ala Ile Ser Arg Phe Glu Ser Glu Asp Leu Xaa Ser Ile 
        755                 760                 765             


Val Glu Leu Glu Trp Leu Leu Glu Ile Asn Arg Leu Xaa His Arg Leu 
    770                 775                 780                 


Leu Cys Lys His Met Xaa Leu Asp Ser Phe Asp Ala Met Phe Arg Glu 
785                 790                 795                 800 


Ala Asn His Asn Val Ser Ala Pro Tyr Gly Arg Ile Xaa Leu His Val 
                805                 810                 815     


Phe Trp Glu Leu Asn Phe Asp Phe Leu Pro Asn Tyr Cys Tyr Asn Gly 
            820                 825                 830         


Ser Xaa Asn Arg Phe Val Arg Xaa Ala Ile Pro Phe Xaa Gln Glu Pro 
        835                 840                 845             


Gln Arg Asp Lys Pro Ala Asn Val Gln Pro Tyr Tyr Leu Tyr Gly Ser 
    850                 855                 860                 


Lys Pro Leu Asn Ile Ala Tyr Ser His Ile Tyr Ser Ser Tyr Arg Asn 
865                 870                 875                 880 


Phe Val Gly Pro Pro His Phe Lys Xaa Ile Cys Arg Leu Leu Gly Tyr 
                885                 890                 895     


Gln Gly Ile Ala Val Val Met Glu Glu Leu Leu Lys Ile Val Lys Ser 
            900                 905                 910         


Leu Leu Gln Gly Xaa Ile Leu Gln Tyr Val Lys Xaa Leu Ile Glu Val 
        915                 920                 925             


Met Pro Lys Ile Cys Arg Leu Pro Arg His Glu Tyr Gly Ser Pro Gly 
    930                 935                 940                 


Ile Leu Glu Phe Phe His His Gln Leu Lys Asp Ile Ile Glu Tyr Ala 
945                 950                 955                 960 


Glu Leu Lys Xaa Asp Val Phe Gln Ser Leu Arg Glu Val Gly Asn Ala 
                965                 970                 975     


Ile Leu Phe Cys Leu Leu Ile Glu Gln Ala Leu Ser Gln Glu Glu Val 
            980                 985                 990         


Cys Asp Leu Leu His Ala Ala Pro  Phe Gln Asn Ile Leu  Pro Arg Val 
        995                 1000                 1005             


Tyr Ile  Lys Glu Gly Glu Arg  Leu Glu Val Arg Met  Lys Arg Leu 
    1010                 1015                 1020             


Glu Ala  Lys Tyr Ala Pro Leu  His Leu Val Pro Leu  Ile Glu Arg 
    1025                 1030                 1035             


Leu Gly  Xaa Pro Gln Gln Ile  Ala Ile Ala Arg Glu  Gly Asp Leu 
    1040                 1045                 1050             


Leu Xaa  Lys Glu Arg Leu Cys  Cys Gly Leu Ser Met  Phe Glu Val 
    1055                 1060                 1065             


Ile Leu  Xaa Arg Ile Arg Ser  Tyr Leu Gln Asp Pro  Ile Trp Arg 
    1070                 1075                 1080             


Gly Pro  Pro Pro Xaa Asn Gly  Val Met His Val Asp  Glu Cys Val 
    1085                 1090                 1095             


Glu Phe  His Arg Leu Trp Ser  Ala Met Gln Phe Val  Tyr Cys Ile 
    1100                 1105                 1110             


Pro Val  Gly Xaa Asn Glu Phe  Xaa Ala Glu Gln Cys  Phe Gly Asp 
    1115                 1120                 1125             


Gly Leu  Asn Trp Ala Gly Cys  Ser Ile Ile Val Leu  Leu Gly Gln 
    1130                 1135                 1140             


Gln Arg  Arg Phe Asp Leu Phe  Asp Phe Cys Tyr His  Leu Leu Lys 
    1145                 1150                 1155             


Val Gln  Arg Gln Asp Gly Lys  Asp Glu Ile Ile Lys  Asn Val Pro 
    1160                 1165                 1170             


Leu Lys  Lys Met Ala Asp Arg  Ile Arg Lys Tyr Gln  Ile Leu Asn 
    1175                 1180                 1185             


Asn Glu  Val Phe Ala Ile Leu  Asn Lys Tyr Met Lys  Ser Val Glu 
    1190                 1195                 1200             


Xaa Asp  Ser Ser Xaa Val Glu  His Val Arg Cys Phe  Gln Pro Pro 
    1205                 1210                 1215             


Ile His  Gln Ser Leu Ala Xaa  Xaa Cys 
    1220                 1225         


<210> 7443
<211> 1057
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(754)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (794)..(794)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (885)..(885)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (918)..(918)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (947)..(947)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1034)..(1034)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1056)
<223> Selenocysteine

<400> 7443
Met Xaa Xaa His Val Xaa Leu Glu Asp Ala Leu Ser Asn Val Asp Leu 
1               5                   10                  15      


Leu Glu Glu Leu Pro Leu Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro 
            20                  25                  30          


Pro Ser Ser Ile Met Tyr Gln Ala Asn Phe Asp Xaa Asn Phe Glu Asp 
        35                  40                  45              


Arg Asn Ala Phe Val Xaa Gly Ile Ala Arg Tyr Ile Glu Gln Ala Xaa 
    50                  55                  60                  


Val His Ser Ser Met Val Met Gly Phe Gly Leu Tyr Leu Met Asp Gly 
65                  70                  75                  80  


Asn Val Ser Asn Ile Tyr Lys Leu Asp Ala Lys Lys Arg Ile Asn Leu 
                85                  90                  95      


Ser Lys Ile Asp Lys Phe Phe Lys Gln Leu Gln Val Val Pro Leu Phe 
            100                 105                 110         


Gly Asp Met Gln Ile Glu Leu Ala Arg Tyr Ile Lys Xaa Ser Ala His 
        115                 120                 125             


Tyr Glu Glu Asn Lys Ser Lys Trp Xaa Cys Xaa Gln Ser Ser Ile Ser 
    130                 135                 140                 


Pro Gln Tyr Asn Ile Cys Glu Gln Met Val Gln Ile Arg Asp Asp His 
145                 150                 155                 160 


Ile Arg Phe Ile Ser Glu Leu Ala Arg Tyr Ser Asn Ser Glu Val Val 
                165                 170                 175     


Xaa Gly Ser Gly Leu Asp Ser Gln Lys Ser Asp Glu Glu Tyr Arg Glu 
            180                 185                 190         


Leu Phe Asp Leu Ala Leu Arg Gly Leu Gln Leu Leu Ser Lys Trp Ser 
        195                 200                 205             


Ala His Val Met Glu Val Tyr Ser Trp Lys Leu Val His Pro Xaa Asp 
    210                 215                 220                 


Lys Phe Cys Asn Lys Asp Cys Pro Gly Xaa Ala Glu Glu Tyr Glu Arg 
225                 230                 235                 240 


Ala Xaa Arg Tyr Asn Tyr Xaa Ser Glu Glu Lys Phe Ala Phe Val Glu 
                245                 250                 255     


Val Ile Ala Met Ile Lys Gly Leu Gln Val Leu Met Gly Arg Met Glu 
            260                 265                 270         


Ser Val Phe Asn Gln Ala Ile Arg Asn Xaa Ile Tyr Ala Ala Leu Gln 
        275                 280                 285             


Asp Phe Ala Gln Val Xaa Leu Arg Glu Pro Leu Arg Gln Ala Val Arg 
    290                 295                 300                 


Lys Lys Lys Asn Val Leu Ile Ser Val Leu Gln Ala Ile Arg Lys Xaa 
305                 310                 315                 320 


Ile Cys Asp Trp Glu Gly Gly Arg Glu Pro Pro Asn Asp Pro Cys Leu 
                325                 330                 335     


Arg Gly Glu Lys Asp Pro Lys Gly Gly Phe Asp Ile Lys Val Pro Arg 
            340                 345                 350         


Arg Ala Val Gly Pro Ser Ser Xaa Gln Leu Tyr Met Val Arg Xaa Met 
        355                 360                 365             


Leu Glu Ser Leu Ile Ala Asp Lys Ser Gly Ser Lys Lys Xaa Leu Arg 
    370                 375                 380                 


Ser Ser Leu Asp Gly Pro Ile Val Leu Ala Ile Glu Asp Phe His Lys 
385                 390                 395                 400 


Gln Ser Phe Phe Phe Xaa His Leu Leu Asn Ile Ser Glu Ala Leu Gln 
                405                 410                 415     


Gln Cys Cys Asp Leu Ser Gln Leu Trp Phe Arg Glu Phe Phe Leu Glu 
            420                 425                 430         


Leu Xaa Met Gly Arg Arg Ile Gln Phe Pro Ile Glu Met Ser Met Pro 
        435                 440                 445             


Trp Ile Leu Xaa Asp His Ile Leu Glu Xaa Lys Glu Pro Ser Met Met 
    450                 455                 460                 


Glu Tyr Val Leu Tyr Pro Leu Asp Leu Tyr Asn Asp Ser Ala Tyr Tyr 
465                 470                 475                 480 


Ala Leu Xaa Lys Phe Lys Lys Gln Phe Leu Tyr Asp Glu Ile Glu Ala 
                485                 490                 495     


Glu Val Asn Leu Cys Phe Asp Gln Phe Val Tyr Lys Leu Ala Asp Gln 
            500                 505                 510         


Ile Phe Ala Tyr Tyr Lys Ala Met Ala Gly Ser Val Leu Leu Asp Lys 
        515                 520                 525             


Arg Phe Arg Ala Glu Cys Lys Asn Tyr Gly Val Ile Ile Pro Tyr Pro 
    530                 535                 540                 


Pro Ser Asn Arg Tyr Glu Xaa Leu Leu Lys Gln Arg His Val Gln Leu 
545                 550                 555                 560 


Leu Gly Arg Ser Ile Asp Leu Asn Arg Leu Ile Xaa Gln Arg Ile Ser 
                565                 570                 575     


Ala Ala Met Tyr Lys Ser Leu Asp Gln Ala Ile Ser Arg Phe Glu Ser 
            580                 585                 590         


Glu Asp Leu Xaa Ser Ile Val Glu Leu Glu Trp Leu Leu Glu Ile Asn 
        595                 600                 605             


Arg Leu Xaa His Arg Leu Leu Cys Lys His Met Xaa Leu Asp Ser Phe 
    610                 615                 620                 


Asp Ala Met Phe Arg Glu Ala Asn His Asn Val Ser Ala Pro Tyr Gly 
625                 630                 635                 640 


Arg Ile Xaa Leu His Val Phe Trp Glu Leu Asn Phe Asp Phe Leu Pro 
                645                 650                 655     


Asn Tyr Cys Tyr Asn Gly Ser Xaa Asn Arg Phe Val Arg Xaa Ala Ile 
            660                 665                 670         


Pro Phe Xaa Gln Glu Pro Gln Arg Asp Lys Pro Ala Asn Val Gln Pro 
        675                 680                 685             


Tyr Tyr Leu Tyr Gly Ser Lys Pro Leu Asn Ile Ala Tyr Ser His Ile 
    690                 695                 700                 


Tyr Ser Ser Tyr Arg Asn Phe Val Gly Pro Pro His Phe Lys Xaa Ile 
705                 710                 715                 720 


Cys Arg Leu Leu Gly Tyr Gln Gly Ile Ala Val Val Met Glu Glu Leu 
                725                 730                 735     


Leu Lys Ile Val Lys Ser Leu Leu Gln Gly Xaa Ile Leu Gln Tyr Val 
            740                 745                 750         


Lys Xaa Leu Ile Glu Val Met Pro Lys Ile Cys Arg Leu Pro Arg His 
        755                 760                 765             


Glu Tyr Gly Ser Pro Gly Ile Leu Glu Phe Phe His His Gln Leu Lys 
    770                 775                 780                 


Asp Ile Ile Glu Tyr Ala Glu Leu Lys Xaa Asp Val Phe Gln Ser Leu 
785                 790                 795                 800 


Arg Glu Val Gly Asn Ala Ile Leu Phe Cys Leu Leu Ile Glu Gln Ala 
                805                 810                 815     


Leu Ser Gln Glu Glu Val Cys Asp Leu Leu His Ala Ala Pro Phe Gln 
            820                 825                 830         


Asn Ile Leu Pro Arg Val Tyr Ile Lys Glu Gly Glu Arg Leu Glu Val 
        835                 840                 845             


Arg Met Lys Arg Leu Glu Ala Lys Tyr Ala Pro Leu His Leu Val Pro 
    850                 855                 860                 


Leu Ile Glu Arg Leu Gly Xaa Pro Gln Gln Ile Ala Ile Ala Arg Glu 
865                 870                 875                 880 


Gly Asp Leu Leu Xaa Lys Glu Arg Leu Cys Cys Gly Leu Ser Met Phe 
                885                 890                 895     


Glu Val Ile Leu Xaa Arg Ile Arg Ser Tyr Leu Gln Asp Pro Ile Trp 
            900                 905                 910         


Arg Gly Pro Pro Pro Xaa Asn Gly Val Met His Val Asp Glu Cys Val 
        915                 920                 925             


Glu Phe His Arg Leu Trp Ser Ala Met Gln Phe Val Tyr Cys Ile Pro 
    930                 935                 940                 


Val Gly Xaa Asn Glu Phe Xaa Ala Glu Gln Cys Phe Gly Asp Gly Leu 
945                 950                 955                 960 


Asn Trp Ala Gly Cys Ser Ile Ile Val Leu Leu Gly Gln Gln Arg Arg 
                965                 970                 975     


Phe Asp Leu Phe Asp Phe Cys Tyr His Leu Leu Lys Val Gln Arg Gln 
            980                 985                 990         


Asp Gly Lys Asp Glu Ile Ile Lys  Asn Val Pro Leu Lys  Lys Met Ala 
        995                 1000                 1005             


Asp Arg  Ile Arg Lys Tyr Gln  Ile Leu Asn Asn Glu  Val Phe Ala 
    1010                 1015                 1020             


Ile Leu  Asn Lys Tyr Met Lys  Ser Val Glu Xaa Asp  Ser Ser Xaa 
    1025                 1030                 1035             


Val Glu  His Val Arg Cys Phe  Gln Pro Pro Ile His  Gln Ser Leu 
    1040                 1045                 1050             


Ala Xaa  Xaa Cys 
    1055         


<210> 7444
<211> 68
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<400> 7444
Met Xaa Xaa His Val Xaa Leu Glu Asp Ala Leu Ser Asn Val Asp Leu 
1               5                   10                  15      


Leu Glu Glu Leu Pro Leu Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro 
            20                  25                  30          


Pro Ser Ser Ile Met Tyr Gln Ala Asn Phe Asp Xaa Asn Phe Glu Asp 
        35                  40                  45              


Arg Asn Ala Phe Val Xaa Gly Ile Ala Ser Ala Arg Pro Ser Ser Gly 
    50                  55                  60                  


Ser Ala Ala Arg 
65              


<210> 7445
<211> 104
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<400> 7445
Ile Ser Ala Gly Lys Ile Lys Gln Phe Cys Lys Xaa Cys Asn Xaa Gln 
1               5                   10                  15      


Val His Leu His Pro Lys Arg Leu Asn His Lys Tyr Asn Pro Val Ser 
            20                  25                  30          


Leu Pro Lys Asp Leu Pro Asp Trp Asp Trp Arg His Gly Cys Ile Pro 
        35                  40                  45              


Cys Gln Asn Met Glu Leu Phe Ala Val Leu Cys Ile Glu Xaa Ser His 
    50                  55                  60                  


Tyr Val Ala Phe Val Lys Tyr Gly Lys Asp Asp Ser Ala Trp Leu Phe 
65                  70                  75                  80  


Phe Asp Ser Met Ala Asp Arg Asp Gly Xaa Glu Asn Ala Phe Leu Leu 
                85                  90                  95      


His Val Ala Gln Gly Ser Gly Leu 
            100                 


<210> 7446
<211> 33
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<400> 7446
Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Xaa Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Xaa Asp 
            20                  25                  30          


Lys 
    


<210> 7447
<211> 166
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<400> 7447
Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Xaa Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Xaa Asp 
            20                  25                  30          


Lys Gln Xaa Gln Lys Leu Leu Lys Val Pro Lys Gly Ser Ile Gly Gln 
        35                  40                  45              


Tyr Ile Gln Asp Arg Ser Val Gly His Ser Arg Ile Pro Ser Ala Lys 
    50                  55                  60                  


Gly Lys Lys Asn Gln Ile Gly Leu Lys Ile Leu Glu Gln Pro His Ala 
65                  70                  75                  80  


Val Leu Phe Val Asp Glu Lys Asp Val Val Glu Ile Asn Glu Lys Phe 
                85                  90                  95      


Xaa Glu Leu Leu Leu Ala Ile Xaa Asn Cys Glu Glu Arg Phe Ser Leu 
            100                 105                 110         


Phe Lys Asn Arg Asn Arg Leu Ser Lys Gly Leu Gln Ile Asp Val Gly 
        115                 120                 125             


Cys Pro Val Lys Val Gln Leu Arg Ser Gly Glu Glu Lys Phe Pro Gly 
    130                 135                 140                 


Val Val Arg Phe Arg Gly Pro Leu Leu Ala Glu Arg Xaa Val Ser Gly 
145                 150                 155                 160 


Ile Phe Phe Gly Val Glu 
                165     


<210> 7448
<211> 304
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<400> 7448
Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Xaa Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Xaa Asp 
            20                  25                  30          


Lys Gln Xaa Gln Lys Leu Leu Lys Val Pro Lys Gly Ser Ile Gly Gln 
        35                  40                  45              


Tyr Ile Gln Asp Arg Ser Val Gly His Ser Arg Ile Pro Ser Ala Lys 
    50                  55                  60                  


Gly Lys Lys Asn Gln Ile Gly Leu Lys Ile Leu Glu Gln Pro His Ala 
65                  70                  75                  80  


Val Leu Phe Val Asp Glu Lys Asp Val Val Glu Ile Asn Glu Lys Phe 
                85                  90                  95      


Xaa Glu Leu Leu Leu Ala Ile Xaa Asn Cys Glu Glu Arg Phe Ser Leu 
            100                 105                 110         


Phe Lys Asn Arg Asn Arg Leu Ser Lys Gly Leu Gln Ile Asp Val Gly 
        115                 120                 125             


Cys Pro Val Lys Val Gln Leu Arg Ser Gly Glu Glu Lys Phe Pro Gly 
    130                 135                 140                 


Val Val Arg Phe Arg Gly Pro Leu Leu Ala Glu Arg Xaa Val Ser Gly 
145                 150                 155                 160 


Ile Phe Phe Gly Val Glu Leu Leu Glu Glu Gly Arg Gly Gln Gly Phe 
                165                 170                 175     


Xaa Asp Gly Val Tyr Gln Gly Lys Gln Leu Phe Gln Cys Asp Glu Asp 
            180                 185                 190         


Cys Gly Val Phe Val Ala Leu Asp Lys Leu Glu Leu Ile Glu Asp Asp 
        195                 200                 205             


Asp Xaa Ala Leu Glu Ser Asp Tyr Ala Gly Pro Gly Asp Xaa Met Gln 
    210                 215                 220                 


Val Glu Leu Pro Pro Leu Glu Ile Asn Ser Arg Val Ser Leu Lys Val 
225                 230                 235                 240 


Gly Glu Xaa Ile Glu Ser Gly Xaa Val Ile Phe Cys Asp Val Leu Pro 
                245                 250                 255     


Gly Lys Glu Ser Leu Gly Tyr Phe Val Gly Val Asp Met Asp Asn Pro 
            260                 265                 270         


Ile Gly Asn Trp Asp Gly Arg Phe Asp Gly Val Gln Leu Cys Ser Phe 
        275                 280                 285             


Ala Cys Val Glu Ser Xaa Ile Leu Leu His Ile Asn Asp Ile Ile Pro 
    290                 295                 300                 


<210> 7449
<211> 771
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<400> 7449
Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Xaa Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Xaa Asp 
            20                  25                  30          


Lys Gln Xaa Gln Lys Leu Leu Lys Val Pro Lys Gly Ser Ile Gly Gln 
        35                  40                  45              


Tyr Ile Gln Asp Arg Ser Val Gly His Ser Arg Ile Pro Ser Ala Lys 
    50                  55                  60                  


Gly Lys Lys Asn Gln Ile Gly Leu Lys Ile Leu Glu Gln Pro His Ala 
65                  70                  75                  80  


Val Leu Phe Val Asp Glu Lys Asp Val Val Glu Ile Asn Glu Lys Phe 
                85                  90                  95      


Xaa Glu Leu Leu Leu Ala Ile Xaa Asn Cys Glu Glu Arg Phe Ser Leu 
            100                 105                 110         


Phe Lys Asn Arg Asn Arg Leu Ser Lys Gly Leu Gln Ile Asp Val Gly 
        115                 120                 125             


Cys Pro Val Lys Val Gln Leu Arg Ser Gly Glu Glu Lys Phe Pro Gly 
    130                 135                 140                 


Val Val Arg Phe Arg Gly Pro Leu Leu Ala Glu Arg Xaa Val Ser Gly 
145                 150                 155                 160 


Ile Phe Phe Gly Val Glu Leu Leu Glu Glu Gly Arg Gly Gln Gly Phe 
                165                 170                 175     


Xaa Asp Gly Val Tyr Gln Gly Lys Gln Leu Phe Gln Cys Asp Glu Asp 
            180                 185                 190         


Cys Gly Val Phe Val Ala Leu Asp Lys Leu Glu Leu Ile Glu Asp Asp 
        195                 200                 205             


Asp Xaa Ala Leu Glu Ser Asp Tyr Ala Gly Pro Gly Asp Xaa Met Gln 
    210                 215                 220                 


Val Glu Leu Pro Pro Leu Glu Ile Asn Ser Arg Val Ser Leu Lys Val 
225                 230                 235                 240 


Gly Glu Xaa Ile Glu Ser Gly Xaa Val Ile Phe Cys Asp Val Leu Pro 
                245                 250                 255     


Gly Lys Glu Ser Leu Gly Tyr Phe Val Gly Val Asp Met Asp Asn Pro 
            260                 265                 270         


Ile Gly Asn Trp Asp Gly Arg Phe Asp Gly Val Gln Leu Cys Ser Phe 
        275                 280                 285             


Ala Cys Val Glu Ser Xaa Ile Leu Leu His Ile Asn Asp Ile Ile Pro 
    290                 295                 300                 


Glu Ser Val Xaa Gln Glu Arg Arg Pro Pro Lys Leu Ala Phe Met Ser 
305                 310                 315                 320 


Arg Gly Val Gly Asp Lys Gly Ser Ser Ser His Asn Lys Pro Lys Ala 
                325                 330                 335     


Xaa Gly Ser Xaa Ser Asp Pro Gly Asn Arg Asn Arg Ser Glu Leu Phe 
            340                 345                 350         


Tyr Xaa Leu Asn Gly Ser Ser Val Asp Ser Gln Pro Gln Ser Lys Ser 
        355                 360                 365             


Lys Asn Xaa Trp Tyr Ile Asp Glu Ala Phe Gly Gly Tyr Leu Ser Glu 
    370                 375                 380                 


Val Val Glu Glu Asn Xaa Pro Pro Lys Met Glu Lys Glu Gly Leu Glu 
385                 390                 395                 400 


Ile Met Ile Gly Lys Lys Lys Gly Ile Gln Gly His Tyr Asn Ser Cys 
                405                 410                 415     


Tyr Leu Asp Ser Xaa Leu Phe Cys Leu Phe Ala Phe Ser Ser Val Leu 
            420                 425                 430         


Asp Xaa Val Leu Leu Arg Pro Lys Glu Lys Asn Asp Val Glu Tyr Tyr 
        435                 440                 445             


Ser Glu Xaa Gln Glu Leu Leu Arg Xaa Glu Ile Val Asn Pro Leu Arg 
    450                 455                 460                 


Ile Tyr Gly Tyr Val Cys Ala Xaa Lys Ile Met Lys Leu Arg Lys Ile 
465                 470                 475                 480 


Leu Glu Lys Val Glu Ala Ala Ser Gly Phe Xaa Ser Glu Glu Lys Asp 
                485                 490                 495     


Pro Glu Glu Phe Leu Asn Ile Leu Phe His His Ile Leu Arg Val Glu 
            500                 505                 510         


Pro Leu Leu Lys Ile Arg Ser Ala Gly Gln Lys Val Gln Asp Cys Tyr 
        515                 520                 525             


Phe Tyr Gln Ile Phe Met Glu Lys Asn Glu Lys Val Gly Val Pro Xaa 
    530                 535                 540                 


Ile Gln Gln Leu Leu Glu Trp Ser Phe Ile Asn Ser Asn Leu Lys Phe 
545                 550                 555                 560 


Ala Glu Ala Pro Ser Cys Leu Ile Ile Gln Met Pro Arg Phe Gly Lys 
                565                 570                 575     


Asp Phe Lys Leu Phe Lys Lys Ile Phe Pro Ser Leu Glu Leu Asn Ile 
            580                 585                 590         


Xaa Asp Leu Leu Glu Asp Xaa Pro Arg Gln Cys Arg Ile Cys Gly Gly 
        595                 600                 605             


Leu Ala Met Tyr Glu Cys Arg Glu Cys Tyr Asp Asp Pro Asp Ile Ser 
    610                 615                 620                 


Ala Gly Lys Ile Lys Gln Phe Cys Lys Xaa Cys Asn Xaa Gln Val His 
625                 630                 635                 640 


Leu His Pro Lys Arg Leu Asn His Lys Tyr Asn Pro Val Ser Leu Pro 
                645                 650                 655     


Lys Asp Leu Pro Asp Trp Asp Trp Arg His Gly Cys Ile Pro Cys Gln 
            660                 665                 670         


Asn Met Glu Leu Phe Ala Val Leu Cys Ile Glu Xaa Ser His Tyr Val 
        675                 680                 685             


Ala Phe Val Lys Tyr Gly Lys Asp Asp Ser Ala Trp Leu Phe Phe Asp 
    690                 695                 700                 


Ser Met Ala Asp Arg Asp Gly Gly Gln Asn Gly Phe Asn Ile Pro Gln 
705                 710                 715                 720 


Val Xaa Pro Cys Pro Glu Val Gly Glu Tyr Leu Lys Met Ser Leu Glu 
                725                 730                 735     


Asp Leu His Ser Leu Asp Ser Arg Arg Ile Gln Gly Cys Ala Arg Arg 
            740                 745                 750         


Leu Leu Cys Asp Ala Tyr Met Cys Met Tyr Gln Ser Pro Xaa Met Ser 
        755                 760                 765             


Leu Tyr Lys 
    770     


<210> 7450
<211> 910
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<400> 7450
Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Xaa Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Xaa Asp 
            20                  25                  30          


Lys Gln Xaa Gln Lys Leu Leu Lys Val Pro Lys Gly Ser Ile Gly Gln 
        35                  40                  45              


Tyr Ile Gln Asp Arg Ser Val Gly His Ser Arg Ile Pro Ser Ala Lys 
    50                  55                  60                  


Gly Lys Lys Asn Gln Ile Gly Leu Lys Ile Leu Glu Gln Pro His Ala 
65                  70                  75                  80  


Val Leu Phe Val Asp Glu Lys Asp Val Val Glu Ile Asn Glu Lys Phe 
                85                  90                  95      


Xaa Glu Leu Leu Leu Ala Ile Xaa Asn Cys Glu Glu Arg Phe Ser Leu 
            100                 105                 110         


Phe Lys Asn Arg Asn Arg Leu Ser Lys Gly Leu Gln Ile Asp Val Gly 
        115                 120                 125             


Cys Pro Val Lys Val Gln Leu Arg Ser Gly Glu Glu Lys Phe Pro Gly 
    130                 135                 140                 


Val Val Arg Phe Arg Gly Pro Leu Leu Ala Glu Arg Xaa Val Ser Gly 
145                 150                 155                 160 


Ile Phe Phe Gly Val Glu Leu Leu Glu Glu Gly Arg Gly Gln Gly Phe 
                165                 170                 175     


Xaa Asp Gly Val Tyr Gln Gly Lys Gln Leu Phe Gln Cys Asp Glu Asp 
            180                 185                 190         


Cys Gly Val Phe Val Ala Leu Asp Lys Leu Glu Leu Ile Glu Asp Asp 
        195                 200                 205             


Asp Xaa Ala Leu Glu Ser Asp Tyr Ala Gly Pro Gly Asp Xaa Met Gln 
    210                 215                 220                 


Val Glu Leu Pro Pro Leu Glu Ile Asn Ser Arg Val Ser Leu Lys Val 
225                 230                 235                 240 


Gly Glu Xaa Ile Glu Ser Gly Xaa Val Ile Phe Cys Asp Val Leu Pro 
                245                 250                 255     


Gly Lys Glu Ser Leu Gly Tyr Phe Val Gly Val Asp Met Asp Asn Pro 
            260                 265                 270         


Ile Gly Asn Trp Asp Gly Arg Phe Asp Gly Val Gln Leu Cys Ser Phe 
        275                 280                 285             


Ala Cys Val Glu Ser Xaa Ile Leu Leu His Ile Asn Asp Ile Ile Pro 
    290                 295                 300                 


Glu Ser Val Xaa Gln Glu Arg Arg Pro Pro Lys Leu Ala Phe Met Ser 
305                 310                 315                 320 


Arg Gly Val Gly Asp Lys Gly Ser Ser Ser His Asn Lys Pro Lys Ala 
                325                 330                 335     


Xaa Gly Ser Xaa Ser Asp Pro Gly Asn Arg Asn Arg Ser Glu Leu Phe 
            340                 345                 350         


Tyr Xaa Leu Asn Gly Ser Ser Val Asp Ser Gln Pro Gln Ser Lys Ser 
        355                 360                 365             


Lys Asn Xaa Trp Tyr Ile Asp Glu Val Ala Glu Asp Pro Ala Lys Ser 
    370                 375                 380                 


Leu Xaa Glu Ile Ser Xaa Asp Phe Asp Arg Ser Ser Pro Pro Leu Gln 
385                 390                 395                 400 


Pro Pro Pro Val Asn Ser Leu Xaa Xaa Glu Asn Arg Phe His Ser Leu 
                405                 410                 415     


Pro Phe Ser Leu Xaa Lys Met Pro Asn Xaa Asn Gly Ser Ile Gly His 
            420                 425                 430         


Ser Pro Leu Ser Leu Ser Ala Gln Ser Val Met Glu Glu Leu Asn Xaa 
        435                 440                 445             


Ala Pro Val Gln Glu Ser Pro Pro Leu Ala Met Pro Pro Gly Asn Ser 
    450                 455                 460                 


His Gly Leu Glu Val Gly Ser Leu Ala Glu Val Lys Glu Asn Pro Pro 
465                 470                 475                 480 


Phe Tyr Gly Val Ile Arg Trp Ile Gly Gln Pro Pro Gly Leu Asn Glu 
                485                 490                 495     


Val Leu Ala Gly Leu Glu Leu Glu Asp Glu Cys Ala Gly Cys Xaa Asp 
            500                 505                 510         


Gly Xaa Phe Arg Gly Xaa Arg Tyr Phe Xaa Cys Ala Leu Lys Lys Ala 
        515                 520                 525             


Leu Phe Val Lys Leu Lys Ser Cys Arg Pro Asp Ser Arg Phe Ala Ser 
    530                 535                 540                 


Leu Gln Pro Val Ser Asn Gln Ile Glu Arg Cys Asn Ser Leu Ala Phe 
545                 550                 555                 560 


Gly Gly Tyr Leu Ser Glu Val Val Glu Glu Asn Xaa Pro Pro Lys Met 
                565                 570                 575     


Glu Lys Glu Gly Leu Glu Ile Met Ile Gly Lys Lys Lys Gly Ile Gln 
            580                 585                 590         


Gly His Tyr Asn Ser Cys Tyr Leu Asp Ser Xaa Leu Phe Cys Leu Phe 
        595                 600                 605             


Ala Phe Ser Ser Val Leu Asp Xaa Val Leu Leu Arg Pro Lys Glu Lys 
    610                 615                 620                 


Asn Asp Val Glu Tyr Tyr Ser Glu Xaa Gln Glu Leu Leu Arg Xaa Glu 
625                 630                 635                 640 


Ile Val Asn Pro Leu Arg Ile Tyr Gly Tyr Val Cys Ala Xaa Lys Ile 
                645                 650                 655     


Met Lys Leu Arg Lys Ile Leu Glu Lys Val Glu Ala Ala Ser Gly Phe 
            660                 665                 670         


Xaa Ser Glu Glu Lys Asp Pro Glu Glu Phe Leu Asn Ile Leu Phe His 
        675                 680                 685             


His Ile Leu Arg Val Glu Pro Leu Leu Lys Ile Arg Ser Ala Gly Gln 
    690                 695                 700                 


Lys Val Gln Asp Cys Tyr Phe Tyr Gln Ile Phe Met Glu Lys Asn Glu 
705                 710                 715                 720 


Lys Val Gly Val Pro Xaa Ile Gln Gln Leu Leu Glu Trp Ser Phe Ile 
                725                 730                 735     


Asn Ser Asn Leu Lys Phe Ala Glu Ala Pro Ser Cys Leu Ile Ile Gln 
            740                 745                 750         


Met Pro Arg Phe Gly Lys Asp Phe Lys Leu Phe Lys Lys Ile Phe Pro 
        755                 760                 765             


Ser Leu Glu Leu Asn Ile Xaa Asp Leu Leu Glu Asp Xaa Pro Arg Gln 
    770                 775                 780                 


Cys Arg Ile Cys Gly Gly Leu Ala Met Tyr Glu Cys Arg Glu Cys Tyr 
785                 790                 795                 800 


Asp Asp Pro Asp Ile Ser Ala Gly Lys Ile Lys Gln Phe Cys Lys Xaa 
                805                 810                 815     


Cys Asn Xaa Gln Val His Leu His Pro Lys Arg Leu Asn His Lys Tyr 
            820                 825                 830         


Asn Pro Val Ser Leu Pro Lys Asp Leu Pro Asp Trp Asp Trp Arg His 
        835                 840                 845             


Gly Cys Ile Pro Cys Gln Asn Met Glu Leu Phe Ala Val Leu Cys Ile 
    850                 855                 860                 


Glu Xaa Ser His Tyr Val Ala Phe Val Lys Tyr Gly Lys Asp Asp Ser 
865                 870                 875                 880 


Ala Trp Leu Phe Phe Asp Ser Met Ala Asp Arg Asp Ala Ala Leu Ser 
                885                 890                 895     


Asp Pro Ala Pro Xaa Ala Phe Trp Cys Gly Pro Pro Val Ala 
            900                 905                 910 


<210> 7451
<211> 953
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (518)..(518)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (603)..(603)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (616)..(616)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (633)..(633)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (654)..(654)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (673)..(673)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (816)..(816)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (948)..(948)
<223> Selenocysteine

<400> 7451
Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Xaa Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Xaa Asp 
            20                  25                  30          


Lys Gln Xaa Gln Lys Leu Leu Lys Val Pro Lys Gly Ser Ile Gly Gln 
        35                  40                  45              


Tyr Ile Gln Asp Arg Ser Val Gly His Ser Arg Ile Pro Ser Ala Lys 
    50                  55                  60                  


Gly Lys Lys Asn Gln Ile Gly Leu Lys Ile Leu Glu Gln Pro His Ala 
65                  70                  75                  80  


Val Leu Phe Val Asp Glu Lys Asp Val Val Glu Ile Asn Glu Lys Phe 
                85                  90                  95      


Xaa Glu Leu Leu Leu Ala Ile Xaa Asn Cys Glu Glu Arg Phe Ser Leu 
            100                 105                 110         


Phe Lys Asn Arg Asn Arg Leu Ser Lys Gly Leu Gln Ile Asp Val Gly 
        115                 120                 125             


Cys Pro Val Lys Val Gln Leu Arg Ser Gly Glu Glu Lys Phe Pro Gly 
    130                 135                 140                 


Val Val Arg Phe Arg Gly Pro Leu Leu Ala Glu Arg Xaa Val Ser Gly 
145                 150                 155                 160 


Ile Phe Phe Gly Val Glu Leu Leu Glu Glu Gly Arg Gly Gln Gly Phe 
                165                 170                 175     


Xaa Asp Gly Val Tyr Gln Gly Lys Gln Leu Phe Gln Cys Asp Glu Asp 
            180                 185                 190         


Cys Gly Val Phe Val Ala Leu Asp Lys Leu Glu Leu Ile Glu Asp Asp 
        195                 200                 205             


Asp Xaa Ala Leu Glu Ser Asp Tyr Ala Gly Pro Gly Asp Xaa Met Gln 
    210                 215                 220                 


Val Glu Leu Pro Pro Leu Glu Ile Asn Ser Arg Val Ser Leu Lys Val 
225                 230                 235                 240 


Gly Glu Xaa Ile Glu Ser Gly Xaa Val Ile Phe Cys Asp Val Leu Pro 
                245                 250                 255     


Gly Lys Glu Ser Leu Gly Tyr Phe Val Gly Val Asp Met Asp Asn Pro 
            260                 265                 270         


Ile Gly Asn Trp Asp Gly Arg Phe Asp Gly Val Gln Leu Cys Ser Phe 
        275                 280                 285             


Ala Cys Val Glu Ser Xaa Ile Leu Leu His Ile Asn Asp Ile Ile Pro 
    290                 295                 300                 


Glu Ser Val Xaa Gln Glu Arg Arg Pro Pro Lys Leu Ala Phe Met Ser 
305                 310                 315                 320 


Arg Gly Val Gly Asp Lys Gly Ser Ser Ser His Asn Lys Pro Lys Ala 
                325                 330                 335     


Xaa Gly Ser Xaa Ser Asp Pro Gly Asn Arg Asn Arg Ser Glu Leu Phe 
            340                 345                 350         


Tyr Xaa Leu Asn Gly Ser Ser Val Asp Ser Gln Pro Gln Ser Lys Ser 
        355                 360                 365             


Lys Asn Xaa Trp Tyr Ile Asp Glu Val Ala Glu Asp Pro Ala Lys Ser 
    370                 375                 380                 


Leu Xaa Glu Ile Ser Xaa Asp Phe Asp Arg Ser Ser Pro Pro Leu Gln 
385                 390                 395                 400 


Pro Pro Pro Val Asn Ser Leu Xaa Xaa Glu Asn Arg Phe His Ser Leu 
                405                 410                 415     


Pro Phe Ser Leu Xaa Lys Met Pro Asn Xaa Asn Gly Ser Ile Gly His 
            420                 425                 430         


Ser Pro Leu Ser Leu Ser Ala Gln Ser Val Met Glu Glu Leu Asn Xaa 
        435                 440                 445             


Ala Pro Val Gln Glu Ser Pro Pro Leu Ala Met Pro Pro Gly Asn Ser 
    450                 455                 460                 


His Gly Leu Glu Val Gly Ser Leu Ala Glu Val Lys Glu Asn Pro Pro 
465                 470                 475                 480 


Phe Tyr Gly Val Ile Arg Trp Ile Gly Gln Pro Pro Gly Leu Asn Glu 
                485                 490                 495     


Val Leu Ala Gly Leu Glu Leu Glu Asp Glu Cys Ala Gly Cys Xaa Asp 
            500                 505                 510         


Gly Xaa Phe Arg Gly Xaa Arg Tyr Phe Xaa Cys Ala Leu Lys Lys Ala 
        515                 520                 525             


Leu Phe Val Lys Leu Lys Ser Cys Arg Pro Asp Ser Arg Phe Ala Ser 
    530                 535                 540                 


Leu Gln Pro Val Ser Asn Gln Ile Glu Arg Cys Asn Ser Leu Ala Phe 
545                 550                 555                 560 


Gly Gly Tyr Leu Ser Glu Val Val Glu Glu Asn Xaa Pro Pro Lys Met 
                565                 570                 575     


Glu Lys Glu Gly Leu Glu Ile Met Ile Gly Lys Lys Lys Gly Ile Gln 
            580                 585                 590         


Gly His Tyr Asn Ser Cys Tyr Leu Asp Ser Xaa Leu Phe Cys Leu Phe 
        595                 600                 605             


Ala Phe Ser Ser Val Leu Asp Xaa Val Leu Leu Arg Pro Lys Glu Lys 
    610                 615                 620                 


Asn Asp Val Glu Tyr Tyr Ser Glu Xaa Gln Glu Leu Leu Arg Xaa Glu 
625                 630                 635                 640 


Ile Val Asn Pro Leu Arg Ile Tyr Gly Tyr Val Cys Ala Xaa Lys Ile 
                645                 650                 655     


Met Lys Leu Arg Lys Ile Leu Glu Lys Val Glu Ala Ala Ser Gly Phe 
            660                 665                 670         


Xaa Ser Glu Glu Lys Asp Pro Glu Glu Phe Leu Asn Ile Leu Phe His 
        675                 680                 685             


His Ile Leu Arg Val Glu Pro Leu Leu Lys Ile Arg Ser Ala Gly Gln 
    690                 695                 700                 


Lys Val Gln Asp Cys Tyr Phe Tyr Gln Ile Phe Met Glu Lys Asn Glu 
705                 710                 715                 720 


Lys Val Gly Val Pro Xaa Ile Gln Gln Leu Leu Glu Trp Ser Phe Ile 
                725                 730                 735     


Asn Ser Asn Leu Lys Phe Ala Glu Ala Pro Ser Cys Leu Ile Ile Gln 
            740                 745                 750         


Met Pro Arg Phe Gly Lys Asp Phe Lys Leu Phe Lys Lys Ile Phe Pro 
        755                 760                 765             


Ser Leu Glu Leu Asn Ile Xaa Asp Leu Leu Glu Asp Xaa Pro Arg Gln 
    770                 775                 780                 


Cys Arg Ile Cys Gly Gly Leu Ala Met Tyr Glu Cys Arg Glu Cys Tyr 
785                 790                 795                 800 


Asp Asp Pro Asp Ile Ser Ala Gly Lys Ile Lys Gln Phe Cys Lys Xaa 
                805                 810                 815     


Cys Asn Xaa Gln Val His Leu His Pro Lys Arg Leu Asn His Lys Tyr 
            820                 825                 830         


Asn Pro Val Ser Leu Pro Lys Asp Leu Pro Asp Trp Asp Trp Arg His 
        835                 840                 845             


Gly Cys Ile Pro Cys Gln Asn Met Glu Leu Phe Ala Val Leu Cys Ile 
    850                 855                 860                 


Glu Xaa Ser His Tyr Val Ala Phe Val Lys Tyr Gly Lys Asp Asp Ser 
865                 870                 875                 880 


Ala Trp Leu Phe Phe Asp Ser Met Ala Asp Arg Asp Gly Gly Gln Asn 
                885                 890                 895     


Gly Phe Asn Ile Pro Gln Val Xaa Pro Cys Pro Glu Val Gly Glu Tyr 
            900                 905                 910         


Leu Lys Met Ser Leu Glu Asp Leu His Ser Leu Asp Ser Arg Arg Ile 
        915                 920                 925             


Gln Gly Cys Ala Arg Arg Leu Leu Cys Asp Ala Tyr Met Cys Met Tyr 
    930                 935                 940                 


Gln Ser Pro Xaa Met Ser Leu Tyr Lys 
945                 950             


<210> 7452
<211> 956
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (729)..(729)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (819)..(819)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (822)..(822)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (951)..(951)
<223> Selenocysteine

<400> 7452
Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Xaa Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Xaa Asp 
            20                  25                  30          


Lys Gln Xaa Gln Lys Leu Leu Lys Val Pro Lys Gly Ser Ile Gly Gln 
        35                  40                  45              


Tyr Ile Gln Asp Arg Ser Val Gly His Ser Arg Ile Pro Ser Ala Lys 
    50                  55                  60                  


Gly Lys Lys Asn Gln Ile Gly Leu Lys Ile Leu Glu Gln Pro His Ala 
65                  70                  75                  80  


Val Leu Phe Val Asp Glu Lys Asp Val Val Glu Ile Asn Glu Lys Phe 
                85                  90                  95      


Xaa Glu Leu Leu Leu Ala Ile Xaa Asn Cys Glu Glu Arg Phe Ser Leu 
            100                 105                 110         


Phe Lys Asn Arg Asn Arg Leu Ser Lys Gly Leu Gln Ile Asp Val Gly 
        115                 120                 125             


Cys Pro Val Lys Val Gln Leu Arg Ser Gly Glu Glu Lys Phe Pro Gly 
    130                 135                 140                 


Val Val Arg Phe Arg Gly Pro Leu Leu Ala Glu Arg Xaa Val Ser Gly 
145                 150                 155                 160 


Ile Phe Phe Gly Val Glu Leu Leu Glu Glu Gly Arg Gly Gln Gly Phe 
                165                 170                 175     


Xaa Asp Gly Val Tyr Gln Gly Lys Gln Leu Phe Gln Cys Asp Glu Asp 
            180                 185                 190         


Cys Gly Val Phe Val Ala Leu Asp Lys Leu Glu Leu Ile Glu Asp Asp 
        195                 200                 205             


Asp Xaa Ala Leu Glu Ser Asp Tyr Ala Gly Pro Gly Asp Xaa Met Gln 
    210                 215                 220                 


Val Glu Leu Pro Pro Leu Glu Ile Asn Ser Arg Val Ser Leu Lys Val 
225                 230                 235                 240 


Gly Glu Xaa Ile Glu Ser Gly Xaa Val Ile Phe Cys Asp Val Leu Pro 
                245                 250                 255     


Gly Lys Glu Ser Leu Gly Tyr Phe Val Gly Val Asp Met Asp Asn Pro 
            260                 265                 270         


Ile Gly Asn Trp Asp Gly Arg Phe Asp Gly Val Gln Leu Cys Ser Phe 
        275                 280                 285             


Ala Cys Val Glu Ser Xaa Ile Leu Leu His Ile Asn Asp Ile Ile Pro 
    290                 295                 300                 


Ala Leu Ser Glu Ser Val Xaa Gln Glu Arg Arg Pro Pro Lys Leu Ala 
305                 310                 315                 320 


Phe Met Ser Arg Gly Val Gly Asp Lys Gly Ser Ser Ser His Asn Lys 
                325                 330                 335     


Pro Lys Ala Xaa Gly Ser Xaa Ser Asp Pro Gly Asn Arg Asn Arg Ser 
            340                 345                 350         


Glu Leu Phe Tyr Xaa Leu Asn Gly Ser Ser Val Asp Ser Gln Pro Gln 
        355                 360                 365             


Ser Lys Ser Lys Asn Xaa Trp Tyr Ile Asp Glu Val Ala Glu Asp Pro 
    370                 375                 380                 


Ala Lys Ser Leu Xaa Glu Ile Ser Xaa Asp Phe Asp Arg Ser Ser Pro 
385                 390                 395                 400 


Pro Leu Gln Pro Pro Pro Val Asn Ser Leu Xaa Xaa Glu Asn Arg Phe 
                405                 410                 415     


His Ser Leu Pro Phe Ser Leu Xaa Lys Met Pro Asn Xaa Asn Gly Ser 
            420                 425                 430         


Ile Gly His Ser Pro Leu Ser Leu Ser Ala Gln Ser Val Met Glu Glu 
        435                 440                 445             


Leu Asn Xaa Ala Pro Val Gln Glu Ser Pro Pro Leu Ala Met Pro Pro 
    450                 455                 460                 


Gly Asn Ser His Gly Leu Glu Val Gly Ser Leu Ala Glu Val Lys Glu 
465                 470                 475                 480 


Asn Pro Pro Phe Tyr Gly Val Ile Arg Trp Ile Gly Gln Pro Pro Gly 
                485                 490                 495     


Leu Asn Glu Val Leu Ala Gly Leu Glu Leu Glu Asp Glu Cys Ala Gly 
            500                 505                 510         


Cys Xaa Asp Gly Xaa Phe Arg Gly Xaa Arg Tyr Phe Xaa Cys Ala Leu 
        515                 520                 525             


Lys Lys Ala Leu Phe Val Lys Leu Lys Ser Cys Arg Pro Asp Ser Arg 
    530                 535                 540                 


Phe Ala Ser Leu Gln Pro Val Ser Asn Gln Ile Glu Arg Cys Asn Ser 
545                 550                 555                 560 


Leu Ala Phe Gly Gly Tyr Leu Ser Glu Val Val Glu Glu Asn Xaa Pro 
                565                 570                 575     


Pro Lys Met Glu Lys Glu Gly Leu Glu Ile Met Ile Gly Lys Lys Lys 
            580                 585                 590         


Gly Ile Gln Gly His Tyr Asn Ser Cys Tyr Leu Asp Ser Xaa Leu Phe 
        595                 600                 605             


Cys Leu Phe Ala Phe Ser Ser Val Leu Asp Xaa Val Leu Leu Arg Pro 
    610                 615                 620                 


Lys Glu Lys Asn Asp Val Glu Tyr Tyr Ser Glu Xaa Gln Glu Leu Leu 
625                 630                 635                 640 


Arg Xaa Glu Ile Val Asn Pro Leu Arg Ile Tyr Gly Tyr Val Cys Ala 
                645                 650                 655     


Xaa Lys Ile Met Lys Leu Arg Lys Ile Leu Glu Lys Val Glu Ala Ala 
            660                 665                 670         


Ser Gly Phe Xaa Ser Glu Glu Lys Asp Pro Glu Glu Phe Leu Asn Ile 
        675                 680                 685             


Leu Phe His His Ile Leu Arg Val Glu Pro Leu Leu Lys Ile Arg Ser 
    690                 695                 700                 


Ala Gly Gln Lys Val Gln Asp Cys Tyr Phe Tyr Gln Ile Phe Met Glu 
705                 710                 715                 720 


Lys Asn Glu Lys Val Gly Val Pro Xaa Ile Gln Gln Leu Leu Glu Trp 
                725                 730                 735     


Ser Phe Ile Asn Ser Asn Leu Lys Phe Ala Glu Ala Pro Ser Cys Leu 
            740                 745                 750         


Ile Ile Gln Met Pro Arg Phe Gly Lys Asp Phe Lys Leu Phe Lys Lys 
        755                 760                 765             


Ile Phe Pro Ser Leu Glu Leu Asn Ile Xaa Asp Leu Leu Glu Asp Xaa 
    770                 775                 780                 


Pro Arg Gln Cys Arg Ile Cys Gly Gly Leu Ala Met Tyr Glu Cys Arg 
785                 790                 795                 800 


Glu Cys Tyr Asp Asp Pro Asp Ile Ser Ala Gly Lys Ile Lys Gln Phe 
                805                 810                 815     


Cys Lys Xaa Cys Asn Xaa Gln Val His Leu His Pro Lys Arg Leu Asn 
            820                 825                 830         


His Lys Tyr Asn Pro Val Ser Leu Pro Lys Asp Leu Pro Asp Trp Asp 
        835                 840                 845             


Trp Arg His Gly Cys Ile Pro Cys Gln Asn Met Glu Leu Phe Ala Val 
    850                 855                 860                 


Leu Cys Ile Glu Xaa Ser His Tyr Val Ala Phe Val Lys Tyr Gly Lys 
865                 870                 875                 880 


Asp Asp Ser Ala Trp Leu Phe Phe Asp Ser Met Ala Asp Arg Asp Gly 
                885                 890                 895     


Gly Gln Asn Gly Phe Asn Ile Pro Gln Val Xaa Pro Cys Pro Glu Val 
            900                 905                 910         


Gly Glu Tyr Leu Lys Met Ser Leu Glu Asp Leu His Ser Leu Asp Ser 
        915                 920                 925             


Arg Arg Ile Gln Gly Cys Ala Arg Arg Leu Leu Cys Asp Ala Tyr Met 
    930                 935                 940                 


Cys Met Tyr Gln Ser Pro Xaa Met Ser Leu Tyr Lys 
945                 950                 955     


<210> 7453
<211> 66
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<400> 7453
Xaa Gly Cys Ile Pro Cys Gln Asn Met Glu Leu Phe Ala Val Leu Cys 
1               5                   10                  15      


Ile Glu Xaa Ser His Tyr Val Ala Phe Val Lys Tyr Gly Lys Asp Asp 
            20                  25                  30          


Ser Ala Trp Leu Phe Phe Asp Ser Met Ala Asp Arg Asp Gly Xaa Glu 
        35                  40                  45              


Asn Ala Phe Leu Leu His Val Ala Gln Gly Ser Gly Phe Gly Ala Ile 
    50                  55                  60                  


Leu His 
65      


<210> 7454
<211> 172
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<400> 7454
Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe Leu Tyr Glu 
1               5                   10                  15      


Ala Met Arg Phe Ser Ser Phe Val Pro Val Xaa Ile Pro His Ala Xaa 
            20                  25                  30          


Xaa Ala Asn Xaa Ser Val Leu Gly Tyr His Ile Pro Lys Asp Xaa Val 
        35                  40                  45              


Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Leu Lys Trp Pro 
    50                  55                  60                  


Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys Asp Gly Leu 
65                  70                  75                  80  


Ile Asn Lys Asp Leu Xaa Ser Arg Val Met Ile Phe Ser Val Gly Lys 
                85                  90                  95      


Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu Phe Leu Phe 
            100                 105                 110         


Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn Pro Asn Glu 
        115                 120                 125             


Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Xaa Ile Lys Pro Lys Ser 
    130                 135                 140                 


Phe Lys Val Asn Val Xaa Leu Arg Glu Ser Met Glu Leu Leu Asp Ser 
145                 150                 155                 160 


Ala Val Gln Asn Leu Gln Ala Lys Glu Xaa Cys Gln 
                165                 170         


<210> 7455
<211> 143
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<400> 7455
Met Gly Xaa Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
1               5                   10                  15      


Ser Ile Gln Gln Xaa Xaa Leu Leu Leu Leu Leu Ser Val Leu Ala Xaa 
            20                  25                  30          


Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
        35                  40                  45              


Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
    50                  55                  60                  


Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
65                  70                  75                  80  


Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                85                  90                  95      


Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
            100                 105                 110         


Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
        115                 120                 125             


Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val 
    130                 135                 140             


<210> 7456
<211> 543
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (337)..(337)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (510)..(510)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<400> 7456
Met Gly Xaa Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
1               5                   10                  15      


Ser Ile Gln Gln Xaa Xaa Leu Leu Leu Leu Leu Ser Val Leu Ala Xaa 
            20                  25                  30          


Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
        35                  40                  45              


Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
    50                  55                  60                  


Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
65                  70                  75                  80  


Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                85                  90                  95      


Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
            100                 105                 110         


Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
        115                 120                 125             


Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
    130                 135                 140                 


Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Xaa Arg Gln Pro 
145                 150                 155                 160 


Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                165                 170                 175     


Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
            180                 185                 190         


Pro Arg Pro Leu Xaa Val Val Ala Val Ala Asn Val Met Ser Ala Val 
        195                 200                 205             


Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
    210                 215                 220                 


Leu Ser His Asn Glu Glu Phe Gly Arg Xaa Val Gly Ala Gly Ser Leu 
225                 230                 235                 240 


Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Xaa 
                245                 250                 255     


Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
            260                 265                 270         


Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
        275                 280                 285             


Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
    290                 295                 300                 


Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
305                 310                 315                 320 


Pro Ala Xaa Ile Xaa Asp Ile Phe Gly Ala Ser Gln Asp Xaa Leu Ser 
                325                 330                 335     


Xaa Ala Leu Gln Trp Leu Leu Leu Leu Phe Xaa Arg Tyr Pro Asp Val 
            340                 345                 350         


Gln Xaa Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
        355                 360                 365             


Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
    370                 375                 380                 


Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Xaa Ile Pro 
385                 390                 395                 400 


His Ala Xaa Xaa Ala Asn Xaa Ser Val Leu Gly Tyr His Ile Pro Lys 
                405                 410                 415     


Asp Xaa Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Leu 
            420                 425                 430         


Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
        435                 440                 445             


Asp Gly Leu Ile Asn Lys Asp Leu Xaa Ser Arg Val Met Ile Phe Ser 
    450                 455                 460                 


Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
465                 470                 475                 480 


Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                485                 490                 495     


Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Xaa Ile Lys 
            500                 505                 510         


Pro Lys Ser Phe Lys Val Asn Val Xaa Leu Arg Glu Ser Met Glu Leu 
        515                 520                 525             


Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Xaa Cys Gln 
    530                 535                 540             


<210> 7457
<211> 448
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<400> 7457
Met Ser Ser Pro Ile Ser Lys Ser Arg Ser Leu Ala Ala Phe Leu Gln 
1               5                   10                  15      


Gln Leu Arg Ser Pro Arg Gln Pro Pro Arg Leu Val Xaa Ser Xaa Ala 
            20                  25                  30          


Tyr Xaa Ser Pro Gln Pro Arg Glu Val Pro Val Cys Pro Leu Xaa Ala 
        35                  40                  45              


Gly Gly Glu Xaa Gln Asn Ala Ala Ala Leu Pro Gly Pro Xaa Ser Trp 
    50                  55                  60                  


Pro Leu Leu Gly Ser Leu Leu Gln Ile Leu Trp Lys Gly Gly Leu Lys 
65                  70                  75                  80  


Lys Gln His Asp Xaa Leu Val Glu Tyr His Lys Lys Tyr Gly Lys Ile 
                85                  90                  95      


Phe Arg Met Lys Leu Gly Ser Phe Glu Ser Val His Leu Gly Ser Pro 
            100                 105                 110         


Cys Leu Leu Glu Ala Leu Tyr Arg Xaa Glu Ser Ala Tyr Pro Gln Arg 
        115                 120                 125             


Leu Glu Ile Lys Pro Trp Lys Ala Tyr Arg Asp Tyr Arg Lys Glu Gly 
    130                 135                 140                 


Tyr Gly Leu Leu Ile Leu Glu Gly Glu Asp Trp Gln Arg Val Arg Ser 
145                 150                 155                 160 


Ala Phe Gln Lys Lys Leu Met Lys Pro Gly Glu Val Met Lys Leu Asp 
                165                 170                 175     


Asn Lys Ile Asn Glu Val Leu Ala Asp Phe Met Gly Arg Ile Asp Glu 
            180                 185                 190         


Leu Cys Asp Glu Arg Gly His Val Glu Asp Leu Tyr Ser Glu Leu Asn 
        195                 200                 205             


Lys Trp Ser Phe Glu Ser Ile Cys Leu Val Leu Tyr Glu Lys Arg Phe 
    210                 215                 220                 


Gly Leu Leu Gln Lys Asn Ala Gly Asp Glu Ala Val Asn Phe Ile Met 
225                 230                 235                 240 


Ala Ile Lys Xaa Met Met Ser Xaa Phe Gly Arg Met Met Val Xaa Pro 
                245                 250                 255     


Val Glu Leu His Lys Ser Leu Asn Xaa Lys Val Trp Gln Asp His Xaa 
            260                 265                 270         


Leu Ala Trp Asp Xaa Ile Phe Lys Ser Val Lys Ala Cys Ile Asp Asn 
        275                 280                 285             


Arg Leu Glu Lys Tyr Ser Gln Gln Pro Ser Ala Asp Phe Leu Cys Asp 
    290                 295                 300                 


Ile Tyr His Gln Asn Arg Leu Ser Lys Lys Glu Leu Tyr Ala Ala Val 
305                 310                 315                 320 


Xaa Glu Leu Gln Leu Ala Ala Val Glu Xaa Xaa Ala Asn Ser Leu Met 
                325                 330                 335     


Trp Ile Leu Tyr Asn Leu Ser Arg Asn Pro Gln Val Gln Gln Lys Leu 
            340                 345                 350         


Leu Lys Glu Ile Gln Ser Val Leu Pro Glu Asn Gln Val Pro Arg Ala 
        355                 360                 365             


Glu Asp Leu Arg Asn Met Pro Tyr Leu Lys Ala Cys Leu Lys Glu Ser 
    370                 375                 380                 


Met Arg Leu Xaa Pro Ser Val Pro Phe Xaa Xaa Arg Xaa Leu Asp Lys 
385                 390                 395                 400 


Ala Xaa Val Leu Gly Glu Tyr Ala Leu Pro Lys Gly Ile Val Arg Lys 
                405                 410                 415     


Tyr Asp Ile Gln Ala Xaa Asp Asn Glu Pro Val Glu Met Leu His Ser 
            420                 425                 430         


Gly Xaa Leu Val Pro Ser Arg Glu Leu Pro Ile Ala Phe Cys Gln Arg 
        435                 440                 445             


<210> 7458
<211> 514
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(331)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (488)..(488)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<400> 7458
Met Ser Ser Pro Ile Ser Lys Ser Arg Ser Leu Ala Ala Phe Leu Gln 
1               5                   10                  15      


Gln Leu Arg Ser Pro Arg Gln Pro Pro Arg Leu Val Xaa Ser Xaa Ala 
            20                  25                  30          


Tyr Xaa Ser Pro Gln Pro Arg Glu Val Pro Val Cys Pro Leu Xaa Ala 
        35                  40                  45              


Gly Gly Glu Xaa Gln Asn Ala Ala Ala Leu Pro Gly Pro Xaa Ser Trp 
    50                  55                  60                  


Pro Leu Leu Gly Ser Leu Leu Gln Ile Leu Trp Lys Gly Gly Leu Lys 
65                  70                  75                  80  


Lys Gln His Asp Xaa Leu Val Glu Tyr His Lys Lys Tyr Gly Lys Ile 
                85                  90                  95      


Phe Arg Met Lys Leu Gly Ser Phe Glu Ser Val His Leu Gly Ser Pro 
            100                 105                 110         


Cys Leu Leu Glu Ala Leu Tyr Arg Xaa Glu Ser Ala Tyr Pro Gln Arg 
        115                 120                 125             


Leu Glu Ile Lys Pro Trp Lys Ala Tyr Arg Asp Tyr Arg Lys Glu Gly 
    130                 135                 140                 


Tyr Gly Leu Leu Ile Leu Glu Gly Glu Asp Trp Gln Arg Val Arg Ser 
145                 150                 155                 160 


Ala Phe Gln Lys Lys Leu Met Lys Pro Gly Glu Val Met Lys Leu Asp 
                165                 170                 175     


Asn Lys Ile Asn Glu Val Leu Ala Asp Phe Met Gly Arg Ile Asp Glu 
            180                 185                 190         


Leu Cys Asp Glu Arg Gly His Val Glu Asp Leu Tyr Ser Glu Leu Asn 
        195                 200                 205             


Lys Trp Ser Phe Glu Ser Ile Cys Leu Val Leu Tyr Glu Lys Arg Phe 
    210                 215                 220                 


Gly Leu Leu Gln Lys Asn Ala Gly Asp Glu Ala Val Asn Phe Ile Met 
225                 230                 235                 240 


Ala Ile Lys Xaa Met Met Ser Xaa Phe Gly Arg Met Met Val Xaa Pro 
                245                 250                 255     


Val Glu Leu His Lys Ser Leu Asn Xaa Lys Val Trp Gln Asp His Xaa 
            260                 265                 270         


Leu Ala Trp Asp Xaa Ile Phe Lys Ser Val Lys Ala Cys Ile Asp Asn 
        275                 280                 285             


Arg Leu Glu Lys Tyr Ser Gln Gln Pro Ser Ala Asp Phe Leu Cys Asp 
    290                 295                 300                 


Ile Tyr His Gln Asn Arg Leu Ser Lys Lys Glu Leu Tyr Ala Ala Val 
305                 310                 315                 320 


Xaa Glu Leu Gln Leu Ala Ala Val Glu Xaa Xaa Ala Asn Ser Leu Met 
                325                 330                 335     


Trp Ile Leu Tyr Asn Leu Ser Arg Asn Pro Gln Val Gln Gln Lys Leu 
            340                 345                 350         


Leu Lys Glu Ile Gln Ser Val Leu Pro Glu Asn Gln Val Pro Arg Ala 
        355                 360                 365             


Glu Asp Leu Arg Asn Met Pro Tyr Leu Lys Ala Cys Leu Lys Glu Ser 
    370                 375                 380                 


Met Arg Leu Xaa Pro Ser Val Pro Phe Xaa Xaa Arg Xaa Leu Asp Lys 
385                 390                 395                 400 


Ala Xaa Val Leu Gly Glu Tyr Ala Leu Pro Lys Gly Xaa Val Leu Met 
                405                 410                 415     


Leu Asn Xaa Gln Val Leu Gly Ser Ser Glu Asp Asn Phe Glu Asp Ser 
            420                 425                 430         


Ser Gln Phe Arg Pro Glu Arg Trp Leu Gln Glu Lys Glu Lys Ile Asn 
        435                 440                 445             


Pro Phe Ala His Leu Pro Phe Gly Val Gly Lys Arg Met Cys Ile Gly 
    450                 455                 460                 


Arg Arg Leu Ala Glu Leu Gln Leu His Leu Ala Leu Cys Trp Ile Val 
465                 470                 475                 480 


Arg Lys Tyr Asp Ile Gln Ala Xaa Asp Asn Glu Pro Val Glu Met Leu 
                485                 490                 495     


His Ser Gly Xaa Leu Val Pro Ser Arg Glu Leu Pro Ile Ala Phe Cys 
            500                 505                 510         


Gln Arg 
        


<210> 7459
<211> 372
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (123)..(123)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(253)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<400> 7459
Met Tyr Ser Cys Phe Ser His Arg Glu Gly Glu Asp Trp Gln Arg Val 
1               5                   10                  15      


Arg Ser Ala Phe Gln Lys Lys Leu Met Lys Pro Gly Glu Val Met Lys 
            20                  25                  30          


Leu Asp Asn Lys Ile Asn Glu Val Leu Ala Asp Phe Met Gly Arg Ile 
        35                  40                  45              


Asp Glu Leu Cys Asp Glu Arg Gly His Val Glu Asp Leu Tyr Ser Glu 
    50                  55                  60                  


Leu Asn Lys Trp Ser Phe Glu Ser Ile Cys Leu Val Leu Tyr Glu Lys 
65                  70                  75                  80  


Arg Phe Gly Leu Leu Gln Lys Asn Ala Gly Asp Glu Ala Val Asn Phe 
                85                  90                  95      


Ile Met Ala Ile Lys Xaa Met Met Ser Xaa Phe Gly Arg Met Met Val 
            100                 105                 110         


Xaa Pro Val Glu Leu His Lys Ser Leu Asn Xaa Lys Val Trp Gln Asp 
        115                 120                 125             


His Xaa Leu Ala Trp Asp Xaa Ile Phe Lys Ser Val Lys Ala Cys Ile 
    130                 135                 140                 


Asp Asn Arg Leu Glu Lys Tyr Ser Gln Gln Pro Ser Ala Asp Phe Leu 
145                 150                 155                 160 


Cys Asp Ile Tyr His Gln Asn Arg Leu Ser Lys Lys Glu Leu Tyr Ala 
                165                 170                 175     


Ala Val Xaa Glu Leu Gln Leu Ala Ala Val Glu Xaa Xaa Ala Asn Ser 
            180                 185                 190         


Leu Met Trp Ile Leu Tyr Asn Leu Ser Arg Asn Pro Gln Val Gln Gln 
        195                 200                 205             


Lys Leu Leu Lys Glu Ile Gln Ser Val Leu Pro Glu Asn Gln Val Pro 
    210                 215                 220                 


Arg Ala Glu Asp Leu Arg Asn Met Pro Tyr Leu Lys Ala Cys Leu Lys 
225                 230                 235                 240 


Glu Ser Met Arg Leu Xaa Pro Ser Val Pro Phe Xaa Xaa Arg Xaa Leu 
                245                 250                 255     


Asp Lys Ala Xaa Val Leu Gly Glu Tyr Ala Leu Pro Lys Gly Xaa Val 
            260                 265                 270         


Leu Met Leu Asn Xaa Gln Val Leu Gly Ser Ser Glu Asp Asn Phe Glu 
        275                 280                 285             


Asp Ser Ser Gln Phe Arg Pro Glu Arg Trp Leu Gln Glu Lys Glu Lys 
    290                 295                 300                 


Ile Asn Pro Phe Ala His Leu Pro Phe Gly Val Gly Lys Arg Met Cys 
305                 310                 315                 320 


Ile Gly Arg Arg Leu Ala Glu Leu Gln Leu His Leu Ala Leu Cys Trp 
                325                 330                 335     


Ile Val Arg Lys Tyr Asp Ile Gln Ala Xaa Asp Asn Glu Pro Val Glu 
            340                 345                 350         


Met Leu His Ser Gly Xaa Leu Val Pro Ser Arg Glu Leu Pro Ile Ala 
        355                 360                 365             


Phe Cys Gln Arg 
    370         


<210> 7460
<211> 497
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (363)..(363)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<400> 7460
Met Gly Leu Pro Ala Leu Leu Ala Ser Ala Leu Cys Xaa Phe Val Leu 
1               5                   10                  15      


Pro Leu Leu Leu Phe Leu Ala Ala Ile Lys Leu Trp Asp Leu Tyr Cys 
            20                  25                  30          


Val Ser Gly Arg Asp Arg Ser Cys Ala Leu Pro Leu Pro Pro Gly Xaa 
        35                  40                  45              


Met Gly Phe Pro Phe Phe Gly Glu Xaa Leu Gln Met Val Leu Gln Arg 
    50                  55                  60                  


Arg Lys Phe Leu Gln Met Lys Arg Arg Lys Tyr Gly Phe Ile Tyr Lys 
65                  70                  75                  80  


Xaa His Leu Phe Gly Arg Pro Xaa Val Arg Val Met Gly Ala Asp Asn 
                85                  90                  95      


Val Arg Arg Ile Leu Leu Gly Glu His Arg Leu Val Ser Val His Trp 
            100                 105                 110         


Pro Ala Ser Val Arg Xaa Ile Leu Gly Ser Gly Cys Leu Ser Asn Leu 
        115                 120                 125             


His Asp Ser Ser His Lys Gln Arg Lys Lys Val Ile Met Arg Ala Phe 
    130                 135                 140                 


Ser Arg Glu Ala Leu Glu Cys Tyr Val Pro Val Ile Xaa Glu Glu Val 
145                 150                 155                 160 


Gly Ser Ser Leu Glu Gln Trp Leu Ser Cys Gly Glu Arg Gly Leu Leu 
                165                 170                 175     


Val Tyr Pro Glu Val Lys Arg Leu Met Phe Arg Ile Ala Met Arg Ile 
            180                 185                 190         


Leu Leu Gly Cys Glu Pro Gln Leu Ala Gly Asp Gly Asp Ser Glu Gln 
        195                 200                 205             


Gln Leu Val Glu Ala Phe Glu Glu Met Xaa Arg Asn Leu Phe Ser Leu 
    210                 215                 220                 


Pro Ile Asp Val Pro Phe Ser Gly Leu Tyr Arg Gly Met Lys Ala Arg 
225                 230                 235                 240 


Asn Leu Ile His Ala Arg Ile Glu Gln Asn Ile Arg Ala Lys Ile Cys 
                245                 250                 255     


Gly Leu Arg Ala Ser Glu Ala Gly Gln Gly Cys Lys Asp Ala Leu Gln 
            260                 265                 270         


Leu Leu Ile Glu His Ser Trp Glu Arg Gly Glu Arg Leu Asp Met Gln 
        275                 280                 285             


Ala Leu Lys Gln Ser Ser Xaa Glu Leu Leu Phe Gly Gly His Glu Xaa 
    290                 295                 300                 


Xaa Ala Ser Ala Ala Xaa Ser Leu Ile Xaa Tyr Leu Gly Leu Tyr Pro 
305                 310                 315                 320 


His Val Leu Gln Lys Val Arg Glu Glu Leu Lys Ser Lys Gly Leu Leu 
                325                 330                 335     


Cys Lys Ser Asn Gln Asp Asn Lys Leu Asp Met Glu Ile Leu Glu Gln 
            340                 345                 350         


Leu Lys Tyr Ile Gly Cys Val Ile Lys Glu Xaa Leu Arg Leu Asn Pro 
        355                 360                 365             


Pro Val Pro Gly Gly Phe Arg Val Ala Leu Lys Xaa Phe Glu Leu Asn 
    370                 375                 380                 


Gly Tyr Gln Ile Pro Lys Gly Trp Asn Val Ile Tyr Ser Ile Cys Asp 
385                 390                 395                 400 


Xaa His Asp Val Ala Glu Ile Phe Xaa Asn Lys Glu Glu Phe Asn Pro 
                405                 410                 415     


Asp Arg Phe Met Leu Pro His Pro Glu Asp Ala Ser Arg Phe Ser Phe 
            420                 425                 430         


Ile Pro Phe Gly Gly Gly Leu Arg Ser Cys Val Gly Lys Glu Phe Ala 
        435                 440                 445             


Lys Ile Leu Leu Lys Ile Phe Xaa Val Glu Leu Ala Arg His Cys Asp 
    450                 455                 460                 


Trp Gln Leu Leu Asn Gly Pro Pro Xaa Met Lys Xaa Ser Pro Xaa Val 
465                 470                 475                 480 


Tyr Pro Val Asp Asn Leu Pro Ala Arg Phe Xaa His Phe His Gly Glu 
                485                 490                 495     


Ile 
    


<210> 7461
<211> 256
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<400> 7461
Met Lys Arg Arg Lys Tyr Gly Phe Ile Tyr Lys Xaa His Leu Phe Gly 
1               5                   10                  15      


Arg Pro Xaa Val Arg Val Met Gly Ala Asp Asn Val Arg Arg Ile Leu 
            20                  25                  30          


Leu Gly Glu His Arg Leu Val Ser Val His Trp Pro Ala Ser Val Arg 
        35                  40                  45              


Xaa Ile Leu Gly Ser Gly Cys Leu Ser Asn Leu His Asp Ser Ser His 
    50                  55                  60                  


Lys Gln Arg Lys Lys Pro Arg Gly Xaa Arg Met Leu Arg Ala Gly Asp 
65                  70                  75                  80  


His Arg Gly Ser Gly Gln Gln Pro Gly Ala Val Ala Glu Leu Arg Arg 
                85                  90                  95      


Ala Arg Pro Pro Gly Leu Pro Arg Gly Glu Ala Pro His Val Pro Asn 
            100                 105                 110         


Arg His Ala His Pro Xaa Gly Leu Arg Xaa Pro Xaa Gly Gly Arg Arg 
        115                 120                 125             


Gly Leu Arg Ala Ala Ala Cys Gly Gly Leu Arg Gly Asn Asp Pro Gln 
    130                 135                 140                 


Ser Leu Leu Ala Ala His Arg Arg Ala Leu Gln Arg Ala Val Pro Gly 
145                 150                 155                 160 


His Glu Gly Ala Glu Pro His Ser Arg Ala His Arg Ala Glu His Ser 
                165                 170                 175     


Arg Gln Asp Leu Arg Ala Ala Gly Ile Arg Gly Gly Pro Gly Leu Gln 
            180                 185                 190         


Arg Arg Ala Ala Ala Val Asp Arg Ala Leu Val Gly Glu Gly Arg Ala 
        195                 200                 205             


Ala Gly His Ala Gly Xaa Lys Ala Ile Phe Asn Arg Xaa Pro Leu Trp 
    210                 215                 220                 


Arg Xaa Arg Asn His Gly Gln Cys Ser His Ile Ser Asp His Leu Pro 
225                 230                 235                 240 


Gly Ala Leu Pro Xaa Cys Ser Pro Glu Ser Ala Arg Arg Ala Glu Glu 
                245                 250                 255     


<210> 7462
<211> 428
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<400> 7462
Met Lys Arg Arg Lys Tyr Gly Phe Ile Tyr Lys Xaa His Leu Phe Gly 
1               5                   10                  15      


Arg Pro Xaa Val Arg Val Met Gly Ala Asp Asn Val Arg Arg Ile Leu 
            20                  25                  30          


Leu Gly Glu His Arg Leu Val Ser Val His Trp Pro Ala Ser Val Arg 
        35                  40                  45              


Xaa Ile Leu Gly Ser Gly Cys Leu Ser Asn Leu His Asp Ser Ser His 
    50                  55                  60                  


Lys Gln Arg Lys Lys Val Ile Met Arg Ala Phe Ser Arg Glu Ala Leu 
65                  70                  75                  80  


Glu Cys Tyr Val Pro Val Ile Xaa Glu Glu Val Gly Ser Ser Leu Glu 
                85                  90                  95      


Gln Trp Leu Ser Cys Gly Glu Arg Gly Leu Leu Val Tyr Pro Glu Val 
            100                 105                 110         


Lys Arg Leu Met Phe Arg Ile Ala Met Arg Ile Leu Leu Gly Cys Glu 
        115                 120                 125             


Pro Gln Leu Ala Gly Asp Gly Asp Ser Glu Gln Gln Leu Val Glu Ala 
    130                 135                 140                 


Phe Glu Glu Met Xaa Arg Asn Leu Phe Ser Leu Pro Ile Asp Val Pro 
145                 150                 155                 160 


Phe Ser Gly Leu Tyr Arg Gly Met Lys Ala Arg Asn Leu Ile His Ala 
                165                 170                 175     


Arg Ile Glu Gln Asn Ile Arg Ala Lys Ile Cys Gly Leu Arg Ala Ser 
            180                 185                 190         


Glu Ala Gly Gln Gly Cys Lys Asp Ala Leu Gln Leu Leu Ile Glu His 
        195                 200                 205             


Ser Trp Glu Arg Gly Glu Arg Leu Asp Met Gln Ala Leu Lys Gln Ser 
    210                 215                 220                 


Ser Xaa Glu Leu Leu Phe Gly Gly His Glu Xaa Xaa Ala Ser Ala Ala 
225                 230                 235                 240 


Xaa Ser Leu Ile Xaa Tyr Leu Gly Leu Tyr Pro His Val Leu Gln Lys 
                245                 250                 255     


Val Arg Glu Glu Leu Lys Ser Lys Gly Leu Leu Cys Lys Ser Asn Gln 
            260                 265                 270         


Asp Asn Lys Leu Asp Met Glu Ile Leu Glu Gln Leu Lys Tyr Ile Gly 
        275                 280                 285             


Cys Val Ile Lys Glu Xaa Leu Arg Leu Asn Pro Pro Val Pro Gly Gly 
    290                 295                 300                 


Phe Arg Val Ala Leu Lys Xaa Phe Glu Leu Asn Gly Tyr Gln Ile Pro 
305                 310                 315                 320 


Lys Gly Trp Asn Val Ile Tyr Ser Ile Cys Asp Xaa His Asp Val Ala 
                325                 330                 335     


Glu Ile Phe Xaa Asn Lys Glu Glu Phe Asn Pro Asp Arg Phe Met Leu 
            340                 345                 350         


Pro His Pro Glu Asp Ala Ser Arg Phe Ser Phe Ile Pro Phe Gly Gly 
        355                 360                 365             


Gly Leu Arg Ser Cys Val Gly Lys Glu Phe Ala Lys Ile Leu Leu Lys 
    370                 375                 380                 


Ile Phe Xaa Val Glu Leu Ala Arg His Cys Asp Trp Gln Leu Leu Asn 
385                 390                 395                 400 


Gly Pro Pro Xaa Met Lys Xaa Ser Pro Xaa Val Tyr Pro Val Asp Asn 
                405                 410                 415     


Leu Pro Ala Arg Phe Xaa His Phe His Gly Glu Ile 
            420                 425             


<210> 7463
<211> 321
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (208)..(208)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Selenocysteine

<400> 7463
Met Ala Ile Arg Val Leu Leu Gly Phe Ser Ile Pro Glu Glu Asp Leu 
1               5                   10                  15      


Gly His Leu Phe Glu Val Tyr Gln Gln Phe Val Asp Asn Val Phe Ser 
            20                  25                  30          


Leu Pro Val Asp Leu Pro Phe Ser Gly Tyr Arg Arg Gly Ile Gln Ala 
        35                  40                  45              


Arg Gln Ile Leu Gln Lys Gly Leu Glu Lys Ala Ile Arg Glu Lys Leu 
    50                  55                  60                  


Gln Cys Xaa Gln Gly Lys Asp Tyr Leu Asp Ala Leu Asp Leu Leu Ile 
65                  70                  75                  80  


Glu Ser Ser Lys Glu His Gly Lys Glu Met Xaa Met Gln Glu Leu Lys 
                85                  90                  95      


Asp Gly Xaa Leu Glu Leu Ile Phe Ala Ala Tyr Ala Xaa Xaa Ala Ser 
            100                 105                 110         


Ala Ser Xaa Ser Leu Ile Met Gln Leu Leu Lys His Pro Xaa Val Leu 
        115                 120                 125             


Glu Lys Leu Arg Asp Glu Leu Arg Ala His Gly Ile Leu His Ser Gly 
    130                 135                 140                 


Gly Cys Pro Cys Glu Gly Xaa Leu Arg Leu Asp Xaa Leu Ser Gly Leu 
145                 150                 155                 160 


Arg Tyr Leu Asp Cys Val Ile Lys Glu Val Met Arg Leu Phe Xaa Pro 
                165                 170                 175     


Ile Ser Gly Gly Tyr Arg Xaa Val Leu Gln Xaa Phe Glu Leu Asp Gly 
            180                 185                 190         


Phe Gln Ile Pro Lys Gly Trp Ser Val Met Tyr Ser Ile Arg Asp Xaa 
        195                 200                 205             


His Asp Xaa Ala Pro Val Phe Lys Asp Val Asn Val Phe Asp Pro Asp 
    210                 215                 220                 


Arg Phe Ser Gln Ala Arg Ser Glu Asp Lys Asp Gly Arg Phe His Tyr 
225                 230                 235                 240 


Leu Pro Phe Gly Gly Gly Val Arg Xaa Cys Leu Gly Lys His Leu Ala 
                245                 250                 255     


Lys Leu Phe Leu Lys Val Leu Ala Val Glu Leu Ala Ser Xaa Ser Arg 
            260                 265                 270         


Phe Glu Leu Ala Xaa Arg Xaa Phe Pro Arg Ile Xaa Leu Val Pro Val 
        275                 280                 285             


Leu His Pro Val Asp Gly Leu Ser Val Lys Phe Phe Gly Leu Asp Ser 
    290                 295                 300                 


Asn Gln Asn Glu Ile Leu Pro Glu Xaa Glu Ala Met Leu Ser Ala Xaa 
305                 310                 315                 320 


Val 
    


<210> 7464
<211> 172
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<400> 7464
Met Lys Asn Lys Xaa Cys Val Leu Val Cys Val Ser Val Phe Gly Gly 
1               5                   10                  15      


Glu Arg Gly Gln Val Xaa Val Pro Arg Val Gly Val Arg Arg Pro Ser 
            20                  25                  30          


Leu Ala Gly Pro Leu Gln Lys Cys Xaa Leu Arg Glu Xaa Arg Val Trp 
        35                  40                  45              


Leu Pro Gln Gly Ser Gly Phe Gln Ser Ser Arg Arg Glu Lys Tyr Gly 
    50                  55                  60                  


Asn Val Phe Lys Xaa His Leu Leu Gly Arg Pro Leu Ile Arg Val Xaa 
65                  70                  75                  80  


Gly Ala Glu Asn Val Arg Lys Ile Leu Met Gly Glu His His Leu Val 
                85                  90                  95      


Ser Xaa Glu Trp Pro Arg Ser Xaa Arg Met Leu Leu Gly Pro Asn Xaa 
            100                 105                 110         


Val Ser Asn Ser Ile Gly Asp Ile His Arg Asn Lys Arg Lys Val Phe 
        115                 120                 125             


Ser Lys Ile Phe Ser His Glu Ala Leu Glu Ser Tyr Leu Pro Lys Ile 
    130                 135                 140                 


Gln Leu Val Ile Gln Asp Xaa Leu Arg Ala Trp Ser Ser His Pro Glu 
145                 150                 155                 160 


Ala Ile Asn Val Tyr Gln Glu Ala Gln Lys Leu Xaa 
                165                 170         


<210> 7465
<211> 512
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (258)..(258)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(504)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<400> 7465
Met Leu Phe Glu Gly Leu Asp Leu Val Ser Ala Leu Ala Xaa Leu Ala 
1               5                   10                  15      


Ala Cys Leu Val Ser Val Xaa Leu Leu Leu Ala Val Ser Gln Gln Leu 
            20                  25                  30          


Trp Gln Leu Arg Trp Ala Ala Xaa Arg Asp Lys Ser Cys Lys Leu Pro 
        35                  40                  45              


Ile Pro Lys Gly Ser Met Gly Phe Pro Leu Ile Gly Glu Xaa Gly His 
    50                  55                  60                  


Trp Leu Leu Gln Gly Ser Gly Phe Gln Ser Ser Arg Arg Glu Lys Tyr 
65                  70                  75                  80  


Gly Asn Val Phe Lys Xaa His Leu Leu Gly Arg Pro Leu Ile Arg Val 
                85                  90                  95      


Xaa Gly Ala Glu Asn Val Arg Lys Ile Leu Met Gly Glu His His Leu 
            100                 105                 110         


Val Ser Xaa Glu Trp Pro Arg Ser Xaa Arg Met Leu Leu Gly Pro Asn 
        115                 120                 125             


Xaa Val Ser Asn Ser Ile Gly Asp Ile His Arg Asn Lys Arg Lys Val 
    130                 135                 140                 


Phe Ser Lys Ile Phe Ser His Glu Ala Leu Glu Ser Tyr Leu Pro Lys 
145                 150                 155                 160 


Ile Gln Leu Val Ile Gln Asp Xaa Leu Arg Ala Trp Ser Ser His Pro 
                165                 170                 175     


Glu Ala Ile Asn Val Tyr Gln Glu Ala Gln Lys Leu Xaa Phe Arg Met 
            180                 185                 190         


Ala Ile Arg Val Leu Leu Gly Phe Ser Ile Pro Glu Glu Asp Leu Gly 
        195                 200                 205             


His Leu Phe Glu Val Tyr Gln Gln Phe Val Asp Asn Val Phe Ser Leu 
    210                 215                 220                 


Pro Val Asp Leu Pro Phe Ser Gly Tyr Arg Arg Gly Ile Gln Ala Arg 
225                 230                 235                 240 


Gln Ile Leu Gln Lys Gly Leu Glu Lys Ala Ile Arg Glu Lys Leu Gln 
                245                 250                 255     


Cys Xaa Gln Gly Lys Asp Tyr Leu Asp Ala Leu Asp Leu Leu Ile Glu 
            260                 265                 270         


Ser Ser Lys Glu His Gly Lys Glu Met Xaa Met Gln Glu Leu Lys Asp 
        275                 280                 285             


Gly Xaa Leu Glu Leu Ile Phe Ala Ala Tyr Ala Xaa Xaa Ala Ser Ala 
    290                 295                 300                 


Ser Xaa Ser Leu Ile Met Gln Leu Leu Lys His Pro Xaa Val Leu Glu 
305                 310                 315                 320 


Lys Leu Arg Asp Glu Leu Arg Ala His Gly Ile Leu His Ser Gly Gly 
                325                 330                 335     


Cys Pro Cys Glu Gly Xaa Leu Arg Leu Asp Xaa Leu Ser Gly Leu Arg 
            340                 345                 350         


Tyr Leu Asp Cys Val Ile Lys Glu Val Met Arg Leu Phe Xaa Pro Ile 
        355                 360                 365             


Ser Gly Gly Tyr Arg Xaa Val Leu Gln Xaa Phe Glu Leu Asp Gly Phe 
    370                 375                 380                 


Gln Ile Pro Lys Gly Trp Ser Val Met Tyr Ser Ile Arg Asp Xaa His 
385                 390                 395                 400 


Asp Xaa Ala Pro Val Phe Lys Asp Val Asn Val Phe Asp Pro Asp Arg 
                405                 410                 415     


Phe Ser Gln Ala Arg Ser Glu Asp Lys Asp Gly Arg Phe His Tyr Leu 
            420                 425                 430         


Pro Phe Gly Gly Gly Val Arg Xaa Cys Leu Gly Lys His Leu Ala Lys 
        435                 440                 445             


Leu Phe Leu Lys Val Leu Ala Val Glu Leu Ala Ser Xaa Ser Arg Phe 
    450                 455                 460                 


Glu Leu Ala Xaa Arg Xaa Phe Pro Arg Ile Xaa Leu Val Pro Val Leu 
465                 470                 475                 480 


His Pro Val Asp Gly Leu Ser Val Lys Phe Phe Gly Leu Asp Ser Asn 
                485                 490                 495     


Gln Asn Glu Ile Leu Pro Glu Xaa Glu Ala Met Leu Ser Ala Xaa Val 
            500                 505                 510         


<210> 7466
<211> 182
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<400> 7466
Met Leu Phe Glu Gly Leu Asp Leu Val Ser Ala Leu Ala Xaa Leu Ala 
1               5                   10                  15      


Ala Cys Leu Val Ser Val Xaa Leu Leu Leu Ala Val Ser Gln Gln Leu 
            20                  25                  30          


Trp Gln Leu Arg Trp Ala Ala Xaa Arg Asp Lys Ser Cys Lys Leu Pro 
        35                  40                  45              


Ile Pro Lys Gly Ser Met Gly Phe Pro Leu Ile Gly Glu Xaa Gly His 
    50                  55                  60                  


Trp Leu Leu Gln Val Phe Ser Lys Ile Phe Ser His Glu Ala Leu Glu 
65                  70                  75                  80  


Ser Tyr Leu Pro Lys Ile Gln Leu Val Ile Gln Asp Xaa Leu Arg Ala 
                85                  90                  95      


Trp Ser Ser His Pro Glu Ala Ile Asn Val Tyr Gln Glu Ala Gln Lys 
            100                 105                 110         


Leu Xaa Phe Arg Met Ala Ile Arg Val Leu Leu Gly Phe Ser Ile Pro 
        115                 120                 125             


Glu Glu Asp Leu Gly His Leu Phe Glu Val Tyr Gln Gln Phe Val Asp 
    130                 135                 140                 


Asn Val Phe Ser Leu Pro Val Asp Leu Pro Phe Ser Gly Tyr Arg Arg 
145                 150                 155                 160 


Gly Ile Gln Ala Arg Gln Ile Leu Gln Lys Gly Leu Glu Lys Ala Ile 
                165                 170                 175     


Arg Glu Lys Leu Gln Cys 
            180         


<210> 7467
<211> 437
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<400> 7467
Met Leu Phe Glu Gly Leu Asp Leu Val Ser Ala Leu Ala Xaa Leu Ala 
1               5                   10                  15      


Ala Cys Leu Val Ser Val Xaa Leu Leu Leu Ala Val Ser Gln Gln Leu 
            20                  25                  30          


Trp Gln Leu Arg Trp Ala Ala Xaa Arg Asp Lys Ser Cys Lys Leu Pro 
        35                  40                  45              


Ile Pro Lys Gly Ser Met Gly Phe Pro Leu Ile Gly Glu Xaa Gly His 
    50                  55                  60                  


Trp Leu Leu Gln Val Phe Ser Lys Ile Phe Ser His Glu Ala Leu Glu 
65                  70                  75                  80  


Ser Tyr Leu Pro Lys Ile Gln Leu Val Ile Gln Asp Xaa Leu Arg Ala 
                85                  90                  95      


Trp Ser Ser His Pro Glu Ala Ile Asn Val Tyr Gln Glu Ala Gln Lys 
            100                 105                 110         


Leu Xaa Phe Arg Met Ala Ile Arg Val Leu Leu Gly Phe Ser Ile Pro 
        115                 120                 125             


Glu Glu Asp Leu Gly His Leu Phe Glu Val Tyr Gln Gln Phe Val Asp 
    130                 135                 140                 


Asn Val Phe Ser Leu Pro Val Asp Leu Pro Phe Ser Gly Tyr Arg Arg 
145                 150                 155                 160 


Gly Ile Gln Ala Arg Gln Ile Leu Gln Lys Gly Leu Glu Lys Ala Ile 
                165                 170                 175     


Arg Glu Lys Leu Gln Cys Xaa Gln Gly Lys Asp Tyr Leu Asp Ala Leu 
            180                 185                 190         


Asp Leu Leu Ile Glu Ser Ser Lys Glu His Gly Lys Glu Met Xaa Met 
        195                 200                 205             


Gln Glu Leu Lys Asp Gly Xaa Leu Glu Leu Ile Phe Ala Ala Tyr Ala 
    210                 215                 220                 


Xaa Xaa Ala Ser Ala Ser Xaa Ser Leu Ile Met Gln Leu Leu Lys His 
225                 230                 235                 240 


Pro Xaa Val Leu Glu Lys Leu Arg Asp Glu Leu Arg Ala His Gly Ile 
                245                 250                 255     


Leu His Ser Gly Gly Cys Pro Cys Glu Gly Xaa Leu Arg Leu Asp Xaa 
            260                 265                 270         


Leu Ser Gly Leu Arg Tyr Leu Asp Cys Val Ile Lys Glu Val Met Arg 
        275                 280                 285             


Leu Phe Xaa Pro Ile Ser Gly Gly Tyr Arg Xaa Val Leu Gln Xaa Phe 
    290                 295                 300                 


Glu Leu Asp Gly Phe Gln Ile Pro Lys Gly Trp Ser Val Met Tyr Ser 
305                 310                 315                 320 


Ile Arg Asp Xaa His Asp Xaa Ala Pro Val Phe Lys Asp Val Asn Val 
                325                 330                 335     


Phe Asp Pro Asp Arg Phe Ser Gln Ala Arg Ser Glu Asp Lys Asp Gly 
            340                 345                 350         


Arg Phe His Tyr Leu Pro Phe Gly Gly Gly Val Arg Xaa Cys Leu Gly 
        355                 360                 365             


Lys His Leu Ala Lys Leu Phe Leu Lys Val Leu Ala Val Glu Leu Ala 
    370                 375                 380                 


Ser Xaa Ser Arg Phe Glu Leu Ala Xaa Arg Xaa Phe Pro Arg Ile Xaa 
385                 390                 395                 400 


Leu Val Pro Val Leu His Pro Val Asp Gly Leu Ser Val Lys Phe Phe 
                405                 410                 415     


Gly Leu Asp Ser Asn Gln Asn Glu Ile Leu Pro Glu Xaa Glu Ala Met 
            420                 425                 430         


Leu Ser Ala Xaa Val 
        435         


<210> 7468
<211> 522
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (494)..(494)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<400> 7468
Met Phe Pro Trp Gly Leu Ser Cys Leu Ser Val Leu Gly Ala Ala Gly 
1               5                   10                  15      


Xaa Ala Leu Leu Cys Ala Gly Leu Leu Leu Ser Leu Ala Gln His Leu 
            20                  25                  30          


Trp Xaa Leu Arg Trp Met Leu Ser Arg Asp Arg Ala Ser Xaa Leu Pro 
        35                  40                  45              


Leu Pro Lys Gly Ser Met Gly Trp Pro Phe Phe Gly Glu Xaa Leu His 
    50                  55                  60                  


Trp Leu Val Gln Gly Ser Arg Phe His Ser Ser Arg Arg Glu Arg Tyr 
65                  70                  75                  80  


Gly Xaa Val Phe Lys Xaa His Leu Leu Gly Arg Pro Val Ile Arg Val 
                85                  90                  95      


Ser Gly Ala Glu Asn Val Arg Xaa Ile Leu Leu Gly Glu His Arg Leu 
            100                 105                 110         


Val Arg Ser Gln Trp Pro Gln Ser Ala His Ile Leu Leu Gly Ser His 
        115                 120                 125             


Xaa Leu Leu Gly Ala Val Gly Glu Pro His Arg Arg Arg Arg Lys Val 
    130                 135                 140                 


Leu Ala Arg Val Phe Ser Arg Ala Ala Leu Glu Arg Tyr Val Pro Arg 
145                 150                 155                 160 


Leu Gln Gly Ala Leu Arg His Glu Val Arg Ser Trp Cys Ala Ala Gly 
                165                 170                 175     


Gly Pro Val Ser Val Tyr Asp Ala Ser Lys Ala Leu Xaa Phe Arg Met 
            180                 185                 190         


Ala Ala Arg Ile Leu Leu Gly Leu Arg Leu Asp Glu Ala Gln Cys Ala 
        195                 200                 205             


Xaa Leu Ala Arg Xaa Phe Glu Gln Leu Val Glu Asn Leu Phe Ser Leu 
    210                 215                 220                 


Pro Leu Asp Val Pro Phe Ser Gly Leu Arg Lys Gly Ile Arg Ala Arg 
225                 230                 235                 240 


Asp Gln Leu His Arg His Leu Glu Gly Ala Ile Ser Glu Lys Leu His 
                245                 250                 255     


Glu Asp Lys Ala Ala Glu Pro Gly Asp Ala Leu Asp Leu Ile Ile His 
            260                 265                 270         


Ser Ala Arg Glu Leu Gly His Glu Pro Ser Met Gln Glu Leu Lys Glu 
        275                 280                 285             


Ser Ala Val Glu Leu Leu Phe Ala Ala Phe Phe Xaa Xaa Ala Ser Ala 
    290                 295                 300                 


Ser Xaa Ser Leu Val Leu Leu Leu Leu Gln His Pro Ala Ala Ile Ala 
305                 310                 315                 320 


Lys Ile Arg Glu Glu Leu Val Ala Gln Gly Leu Gly Arg Ala Cys Gly 
                325                 330                 335     


Cys Ala Pro Gly Ala Ala Gly Gly Ser Glu Gly Pro Pro Pro Asp Cys 
            340                 345                 350         


Gly Cys Glu Pro Asp Leu Ser Leu Ala Ala Leu Gly Arg Leu Arg Tyr 
        355                 360                 365             


Val Asp Cys Val Val Lys Glu Val Leu Arg Leu Leu Pro Pro Val Ser 
    370                 375                 380                 


Gly Gly Tyr Arg Xaa Ala Leu Arg Xaa Phe Glu Leu Asp Gly Tyr Gln 
385                 390                 395                 400 


Ile Pro Lys Gly Trp Ser Val Met Tyr Ser Ile Arg Asp Xaa His Glu 
                405                 410                 415     


Xaa Ala Ala Val Tyr Arg Ser Pro Pro Glu Gly Phe Asp Pro Glu Arg 
            420                 425                 430         


Phe Gly Ala Ala Arg Glu Asp Ser Arg Gly Ala Ser Ser Arg Phe His 
        435                 440                 445             


Tyr Ile Pro Phe Gly Gly Gly Ala Arg Ser Cys Leu Gly Gln Glu Leu 
    450                 455                 460                 


Ala Gln Ala Val Leu Gln Leu Leu Ala Val Glu Leu Val Arg Xaa Ala 
465                 470                 475                 480 


Arg Trp Glu Leu Ala Xaa Pro Ala Phe Pro Ala Met Gln Xaa Val Pro 
                485                 490                 495     


Ile Val His Pro Val Asp Gly Leu Arg Leu Phe Phe His Pro Leu Xaa 
            500                 505                 510         


Pro Ser Val Ala Gly Asn Gly Leu Cys Leu 
        515                 520         


<210> 7469
<211> 302
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<400> 7469
Met Phe Pro Trp Gly Leu Ser Cys Leu Ser Val Leu Gly Ala Ala Gly 
1               5                   10                  15      


Xaa Ala Leu Leu Cys Ala Gly Leu Leu Leu Ser Leu Ala Gln His Leu 
            20                  25                  30          


Trp Xaa Leu Arg Trp Met Leu Ser Arg Asp Arg Ala Ser Xaa Leu Pro 
        35                  40                  45              


Leu Pro Lys Gly Ser Met Gly Trp Pro Phe Phe Gly Glu Xaa Leu His 
    50                  55                  60                  


Trp Leu Val Gln Gly Ser Arg Phe His Ser Ser Arg Arg Glu Arg Tyr 
65                  70                  75                  80  


Gly Xaa Val Phe Lys Xaa His Leu Leu Gly Arg Pro Val Ile Arg Val 
                85                  90                  95      


Ser Gly Ala Glu Asn Val Arg Xaa Ile Leu Leu Gly Glu His Arg Leu 
            100                 105                 110         


Val Arg Ser Gln Trp Pro Gln Ser Ala His Ile Leu Leu Gly Ser His 
        115                 120                 125             


Xaa Leu Leu Gly Ala Val Gly Glu Pro His Arg Arg Arg Arg Lys Val 
    130                 135                 140                 


Leu Ala Arg Val Phe Ser Arg Ala Ala Leu Glu Arg Tyr Val Pro Arg 
145                 150                 155                 160 


Leu Gln Gly Ala Leu Arg His Glu Val Arg Ser Trp Cys Ala Ala Gly 
                165                 170                 175     


Gly Pro Val Ser Val Tyr Asp Ala Ser Lys Ala Leu Xaa Phe Arg Met 
            180                 185                 190         


Ala Ala Arg Ile Leu Leu Gly Leu Arg Leu Asp Glu Ala Gln Cys Ala 
        195                 200                 205             


Xaa Leu Ala Arg Xaa Phe Glu Gln Leu Val Glu Asn Leu Phe Ser Leu 
    210                 215                 220                 


Pro Leu Asp Val Pro Phe Ser Gly Leu Arg Lys Val Arg Pro Pro Arg 
225                 230                 235                 240 


Leu Gln Xaa Phe Leu Arg Gly Ser Ala Ala Arg Ala Gly Leu Pro Asp 
                245                 250                 255     


Pro Asp Gly Xaa Pro Ser Ala His Pro Ala Arg Pro Ser Pro Leu Leu 
            260                 265                 270         


Gly Xaa Ala Ala Gly Pro Gly Gly Gly Arg Arg Cys Gly Gly Gly Val 
        275                 280                 285             


Ala Val Gly Ser Gly Pro Gly Leu Cys Ala Gly Ser Leu Val 
    290                 295                 300         


<210> 7470
<211> 157
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<400> 7470
Met Ala Met Pro His Trp Leu Arg His Leu Val Pro Gly Pro Trp Gly 
1               5                   10                  15      


Arg Leu Cys Arg Asp Trp Asp Gln Met Phe Ala Phe Ala Gln Arg His 
            20                  25                  30          


Val Glu Arg Arg Glu Ala Glu Ala Ala Met Arg Asn Gly Gly Gln Pro 
        35                  40                  45              


Glu Lys Asp Leu Glu Ser Gly Ala His Leu Xaa His Phe Leu Phe Arg 
    50                  55                  60                  


Glu Glu Leu Pro Ala Gln Ser Ile Leu Gly Asn Val Xaa Glu Leu Leu 
65                  70                  75                  80  


Leu Ala Gly Val Asp Xaa Val Ser Asn Xaa Leu Ser Trp Ala Leu Tyr 
                85                  90                  95      


Glu Leu Ser Arg His Pro Glu Val Gln Xaa Ala Leu His Ser Glu Ile 
            100                 105                 110         


Xaa Ala Ala Leu Ser Pro Gly Ser Ser Ala Tyr Pro Ser Ala Xaa Val 
        115                 120                 125             


Leu Ser Gln Leu Pro Leu Leu Lys Ala Val Val Lys Glu Val Leu Arg 
    130                 135                 140                 


Leu Tyr Pro Val Val Pro Gly Asn Ser Arg Val Pro Asp 
145                 150                 155         


<210> 7471
<211> 508
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (362)..(362)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (474)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (493)..(493)
<223> Selenocysteine

<400> 7471
Met Xaa Gln Xaa Leu Lys Tyr Ala Ser Arg Val Phe His Arg Val Arg 
1               5                   10                  15      


Trp Ala Pro Glu Leu Gly Ala Ser Leu Gly Tyr Arg Glu Tyr His Ser 
            20                  25                  30          


Ala Arg Arg Ser Leu Ala Asp Ile Pro Gly Pro Ser Xaa Pro Ser Phe 
        35                  40                  45              


Leu Ala Glu Leu Phe Cys Lys Gly Gly Leu Ser Arg Leu His Glu Leu 
    50                  55                  60                  


Gln Val Gln Gly Ala Ala His Phe Gly Pro Val Trp Leu Ala Ser Phe 
65                  70                  75                  80  


Gly Xaa Val Arg Xaa Val Tyr Val Ala Ala Pro Ala Leu Val Glu Glu 
                85                  90                  95      


Leu Leu Arg Gln Glu Gly Pro Arg Pro Glu Arg Cys Ser Phe Ser Pro 
            100                 105                 110         


Trp Xaa Glu His Arg Arg Cys Arg Gln Arg Ala Cys Gly Leu Leu Xaa 
        115                 120                 125             


Ala Glu Gly Glu Glu Trp Gln Arg Leu Arg Ser Leu Leu Ala Pro Leu 
    130                 135                 140                 


Leu Leu Arg Pro Gln Ala Ala Ala Arg Tyr Ala Gly Xaa Leu Asn Asn 
145                 150                 155                 160 


Val Val Cys Asp Leu Val Arg Arg Leu Arg Arg Gln Arg Gly Arg Gly 
                165                 170                 175     


Xaa Gly Pro Pro Ala Leu Val Arg Asp Val Ala Gly Glu Phe Tyr Lys 
            180                 185                 190         


Phe Gly Leu Glu Gly Ile Ala Ala Val Leu Leu Gly Ser Arg Leu Gly 
        195                 200                 205             


Cys Leu Glu Ala Gln Val Pro Pro Asp Xaa Glu Xaa Phe Ile Arg Ala 
    210                 215                 220                 


Val Gly Ser Val Phe Val Ser Xaa Leu Leu Xaa Met Ala Met Pro His 
225                 230                 235                 240 


Trp Leu Arg His Leu Val Pro Gly Pro Trp Gly Arg Leu Cys Arg Asp 
                245                 250                 255     


Trp Asp Gln Met Phe Ala Phe Ala Gln Arg His Val Glu Arg Arg Glu 
            260                 265                 270         


Ala Glu Ala Ala Met Arg Asn Gly Gly Gln Pro Glu Lys Asp Leu Glu 
        275                 280                 285             


Ser Gly Ala His Leu Xaa His Phe Leu Phe Arg Glu Glu Leu Pro Ala 
    290                 295                 300                 


Gln Ser Ile Leu Gly Asn Val Xaa Glu Leu Leu Leu Ala Gly Val Asp 
305                 310                 315                 320 


Xaa Val Ser Asn Xaa Leu Ser Trp Ala Leu Tyr Glu Leu Ser Arg His 
                325                 330                 335     


Pro Glu Val Gln Xaa Ala Leu His Ser Glu Ile Xaa Ala Ala Leu Ser 
            340                 345                 350         


Pro Gly Ser Ser Ala Tyr Pro Ser Ala Xaa Val Leu Ser Gln Leu Pro 
        355                 360                 365             


Leu Leu Lys Ala Val Val Lys Glu Val Leu Arg Leu Tyr Pro Val Val 
    370                 375                 380                 


Pro Gly Asn Ser Arg Val Pro Asp Lys Asp Ile His Val Gly Asp Tyr 
385                 390                 395                 400 


Ile Ile Pro Lys Asn Xaa Leu Val Xaa Leu Cys His Tyr Ala Xaa Ser 
                405                 410                 415     


Arg Asp Pro Ala Gln Phe Pro Glu Pro Asn Ser Phe Arg Pro Ala Arg 
            420                 425                 430         


Trp Leu Gly Glu Gly Pro Xaa Pro His Pro Phe Ala Ser Leu Pro Phe 
        435                 440                 445             


Gly Phe Gly Lys Arg Ser Cys Met Gly Arg Arg Leu Ala Glu Leu Glu 
    450                 455                 460                 


Leu Gln Met Ala Leu Ala Gln Ile Leu Xaa His Phe Glu Val Gln Pro 
465                 470                 475                 480 


Glu Pro Gly Ala Ala Pro Val Arg Pro Lys Xaa Arg Xaa Val Leu Val 
                485                 490                 495     


Pro Glu Arg Ser Ile Asn Leu Gln Phe Leu Asp Arg 
            500                 505             


<210> 7472
<211> 234
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<400> 7472
Xaa Xaa Leu Ala Gly Pro Arg Leu Pro Gly Ile Arg Glu Lys Ser Arg 
1               5                   10                  15      


Ser Pro Gly Ser Ser Gln Leu Arg Leu Leu Glu Leu Arg His Ser Xaa 
            20                  25                  30          


Leu Leu Lys Lys Val Gln Gly Ala Ala His Phe Gly Pro Val Trp Leu 
        35                  40                  45              


Ala Ser Phe Gly Xaa Val Arg Xaa Val Tyr Val Ala Ala Pro Ala Leu 
    50                  55                  60                  


Val Glu Glu Leu Leu Arg Gln Glu Gly Pro Arg Pro Glu Arg Cys Ser 
65                  70                  75                  80  


Phe Ser Pro Trp Xaa Glu His Arg Arg Cys Arg Gln Arg Ala Cys Gly 
                85                  90                  95      


Leu Leu Xaa Ala Glu Gly Glu Glu Trp Gln Arg Leu Arg Ser Leu Leu 
            100                 105                 110         


Ala Pro Leu Leu Leu Arg Pro Gln Ala Ala Ala Arg Tyr Ala Gly Xaa 
        115                 120                 125             


Leu Asn Asn Val Val Cys Asp Leu Val Arg Arg Leu Arg Arg Gln Arg 
    130                 135                 140                 


Gly Arg Gly Xaa Gly Pro Pro Ala Leu Val Arg Asp Val Ala Gly Glu 
145                 150                 155                 160 


Phe Tyr Lys Phe Gly Leu Glu Gly Ile Ala Ala Val Leu Leu Gly Ser 
                165                 170                 175     


Arg Leu Gly Cys Leu Glu Ala Gln Val Pro Pro Asp Xaa Glu Xaa Phe 
            180                 185                 190         


Ile Arg Ala Val Gly Ser Val Phe Val Ser Xaa Leu Leu Xaa Met Ala 
        195                 200                 205             


Met Pro His Trp Leu Arg His Leu Val Pro Gly Pro Trp Gly Arg Leu 
    210                 215                 220                 


Cys Arg Asp Trp Asp Gln Met Phe Ala Phe 
225                 230                 


<210> 7473
<211> 506
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(368)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<400> 7473
Met Ala Gly Glu Val Ser Ala Ala Xaa Gly Arg Phe Ser Leu Glu Arg 
1               5                   10                  15      


Leu Gly Leu Pro Gly Leu Ala Leu Ala Ala Ala Leu Leu Leu Leu Ala 
            20                  25                  30          


Leu Cys Leu Leu Val Arg Arg Xaa Arg Arg Pro Gly Glu Pro Pro Leu 
        35                  40                  45              


Ile Lys Gly Trp Leu Pro Tyr Leu Gly Val Val Leu Asn Leu Arg Lys 
    50                  55                  60                  


Asp Pro Leu Arg Phe Met Lys Xaa Leu Gln Lys Gln His Gly Asp Xaa 
65                  70                  75                  80  


Phe Xaa Val Leu Leu Gly Gly Lys Tyr Ile Xaa Phe Ile Leu Asp Pro 
                85                  90                  95      


Phe Gln Tyr Gln Leu Val Ile Lys Asn His Lys Gln Leu Ser Phe Arg 
            100                 105                 110         


Val Phe Ser Asn Lys Leu Leu Glu Lys Ala Phe Ser Ile Ser Gln Leu 
        115                 120                 125             


Gln Lys Asn His Asp Met Asn Asp Glu Leu His Leu Cys Tyr Gln Phe 
    130                 135                 140                 


Leu Gln Gly Lys Ser Leu Asp Ile Leu Leu Glu Ser Met Met Gln Asn 
145                 150                 155                 160 


Leu Lys Gln Val Phe Glu Pro Gln Leu Leu Lys Xaa Xaa Ser Trp Asp 
                165                 170                 175     


Xaa Ala Glu Leu Tyr Pro Phe Cys Ser Ser Ile Ile Phe Glu Ile Xaa 
            180                 185                 190         


Phe Xaa Xaa Ile Tyr Gly Lys Val Ile Val Cys Asp Asn Asn Lys Phe 
        195                 200                 205             


Ile Ser Glu Leu Arg Asp Asp Phe Leu Lys Phe Asp Asp Lys Phe Ala 
    210                 215                 220                 


Tyr Leu Val Ser Asn Ile Pro Ile Glu Leu Leu Gly Asn Val Lys Ser 
225                 230                 235                 240 


Ile Arg Glu Lys Ile Ile Lys Cys Phe Ser Ser Glu Lys Leu Ala Lys 
                245                 250                 255     


Met Gln Gly Trp Ser Glu Val Phe Gln Ser Arg Gln Asp Val Leu Glu 
            260                 265                 270         


Lys Tyr Tyr Val His Glu Asp Leu Glu Ile Gly Ala His His Leu Gly 
        275                 280                 285             


Phe Leu Trp Ala Ser Val Ala Asn Xaa Ile Pro Xaa Met Phe Trp Ala 
    290                 295                 300                 


Met Tyr Tyr Leu Leu Arg His Pro Glu Ala Met Ala Ala Val Arg Asp 
305                 310                 315                 320 


Glu Ile Asp Arg Leu Leu Gln Ser Xaa Gly Gln Lys Lys Gly Ser Gly 
                325                 330                 335     


Phe Pro Ile His Leu Xaa Arg Glu Gln Leu Asp Ser Leu Ile Cys Leu 
            340                 345                 350         


Glu Ser Ser Ile Phe Glu Ala Leu Arg Leu Ser Ser Tyr Ser Xaa Xaa 
        355                 360                 365             


Ile Arg Phe Val Glu Glu Asp Leu Xaa Leu Ser Ser Glu Xaa Gly Asp 
    370                 375                 380                 


Tyr Cys Val Arg Lys Gly Asp Leu Val Ala Ile Phe Pro Pro Val Leu 
385                 390                 395                 400 


His Gly Asp Pro Glu Ile Phe Glu Ala Pro Glu Glu Phe Arg Tyr Asp 
                405                 410                 415     


Arg Phe Ile Glu Asp Gly Lys Lys Lys Xaa Xaa Phe Phe Lys Arg Gly 
            420                 425                 430         


Lys Lys Leu Lys Cys Tyr Leu Met Pro Phe Gly Xaa Gly Xaa Ser Lys 
        435                 440                 445             


Cys Pro Gly Arg Phe Phe Ala Leu Met Glu Ile Lys Gln Leu Leu Val 
    450                 455                 460                 


Ile Leu Leu Xaa Tyr Phe Asp Leu Glu Ile Ile Asp Asp Lys Pro Ile 
465                 470                 475                 480 


Gly Leu Asn Tyr Ser Arg Leu Leu Phe Gly Ile Gln Tyr Pro Asp Ser 
                485                 490                 495     


Asp Val Leu Phe Arg Tyr Lys Val Lys Ser 
            500                 505     


<210> 7474
<211> 381
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(234)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<400> 7474
Met Ser Ser Arg Ile Ala Arg Ala Leu Ala Leu Val Val Xaa Leu Leu 
1               5                   10                  15      


His Leu Xaa Arg Leu Ala Leu Ser Xaa Cys Pro Ala Ala Cys His Cys 
            20                  25                  30          


Pro Leu Glu Ala Pro Lys Cys Ala Pro Gly Val Gly Leu Val Arg Asp 
        35                  40                  45              


Gly Cys Gly Cys Cys Lys Val Cys Ala Lys Gln Leu Asn Glu Asp Cys 
    50                  55                  60                  


Ser Lys Xaa Gln Pro Cys Asp His Xaa Lys Gly Leu Glu Cys Asn Phe 
65                  70                  75                  80  


Gly Ala Ser Ser Xaa Ala Leu Lys Gly Ile Cys Arg Ala Gln Ser Glu 
                85                  90                  95      


Gly Arg Pro Cys Glu Tyr Asn Ser Arg Ile Tyr Gln Asn Gly Glu Ser 
            100                 105                 110         


Phe Gln Pro Asn Cys Lys His Gln Cys Xaa Cys Ile Asp Gly Ala Val 
        115                 120                 125             


Gly Cys Ile Pro Leu Cys Pro Gln Glu Leu Ser Leu Pro Asn Leu Gly 
    130                 135                 140                 


Cys Pro Asn Pro Arg Leu Val Lys Val Xaa Gly Gln Cys Cys Glu Glu 
145                 150                 155                 160 


Trp Val Cys Asp Glu Asp Ser Ile Lys Asp Pro Met Glu Asp Gln Asp 
                165                 170                 175     


Gly Leu Leu Gly Lys Glu Leu Gly Phe Asp Ala Ser Glu Val Glu Leu 
            180                 185                 190         


Xaa Arg Asn Asn Glu Leu Ile Ala Val Gly Lys Gly Ser Ser Leu Lys 
        195                 200                 205             


Arg Leu Pro Val Phe Gly Met Glu Pro Arg Ile Leu Tyr Asn Pro Leu 
    210                 215                 220                 


Gln Gly Gln Lys Cys Ile Val Gln Xaa Xaa Ser Trp Ser Gln Cys Ser 
225                 230                 235                 240 


Lys Xaa Cys Gly Xaa Gly Ile Ser Xaa Arg Val Xaa Asn Asp Asn Pro 
                245                 250                 255     


Glu Cys Arg Leu Val Lys Glu Xaa Arg Ile Cys Glu Val Arg Pro Cys 
            260                 265                 270         


Gly Gln Pro Val Tyr Ser Ser Leu Lys Lys Gly Lys Lys Cys Ser Lys 
        275                 280                 285             


Xaa Lys Lys Ser Pro Glu Pro Val Arg Phe Xaa Tyr Ala Gly Cys Leu 
    290                 295                 300                 


Ser Val Lys Lys Tyr Arg Pro Lys Tyr Cys Gly Ser Cys Val Asp Gly 
305                 310                 315                 320 


Arg Cys Cys Xaa Pro Gln Leu Xaa Arg Xaa Val Lys Met Arg Phe Arg 
                325                 330                 335     


Cys Glu Asp Gly Glu Xaa Phe Ser Lys Asn Val Met Met Ile Gln Ser 
            340                 345                 350         


Cys Lys Cys Asn Tyr Asn Cys Pro His Ala Asn Glu Ala Ala Phe Pro 
        355                 360                 365             


Phe Tyr Arg Leu Phe Asn Asp Ile His Lys Phe Arg Asp 
    370                 375                 380     


<210> 7475
<211> 337
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<400> 7475
Met Asp Glu Xaa Gly Asn Leu Xaa Val Ser Ser Ala Xaa Cys His Asp 
1               5                   10                  15      


Xaa Ile Asp Asp Phe Arg Asn Gln Val Tyr Ser Xaa Leu Tyr Ser Met 
            20                  25                  30          


Ile Ser Val Val Gly Phe Phe Gly Asn Gly Phe Val Leu Tyr Val Leu 
        35                  40                  45              


Ile Lys Xaa Tyr His Lys Lys Ser Ala Phe Gln Val Tyr Met Ile Asn 
    50                  55                  60                  


Leu Ala Val Ala Asp Leu Leu Cys Val Cys Xaa Leu Pro Leu Arg Val 
65                  70                  75                  80  


Val Tyr Tyr Val His Lys Gly Ile Trp Leu Phe Gly Asp Phe Leu Cys 
                85                  90                  95      


Arg Leu Ser Xaa Tyr Ala Leu Tyr Val Asn Leu Tyr Cys Ser Ile Phe 
            100                 105                 110         


Phe Met Xaa Ala Met Ser Phe Phe Arg Cys Ile Ala Ile Val Phe Pro 
        115                 120                 125             


Val Gln Asn Ile Asn Leu Val Xaa Gln Lys Lys Ala Arg Phe Val Cys 
    130                 135                 140                 


Val Gly Ile Trp Ile Phe Val Ile Leu Xaa Ser Ser Pro Phe Leu Met 
145                 150                 155                 160 


Ala Lys Pro Gln Lys Asp Glu Lys Asn Asn Xaa Lys Cys Phe Glu Pro 
                165                 170                 175     


Pro Gln Asp Asn Gln Xaa Lys Asn His Val Leu Val Leu His Tyr Val 
            180                 185                 190         


Ser Leu Phe Val Gly Phe Ile Ile Pro Phe Val Ile Ile Ile Val Cys 
        195                 200                 205             


Tyr Xaa Met Ile Ile Leu Xaa Leu Leu Lys Lys Ser Met Lys Lys Asn 
    210                 215                 220                 


Leu Ser Ser His Lys Lys Ala Ile Gly Met Ile Met Val Val Xaa Ala 
225                 230                 235                 240 


Ala Phe Leu Val Ser Phe Met Pro Tyr His Ile Gln Arg Xaa Ile His 
                245                 250                 255     


Leu His Phe Leu His Asn Glu Xaa Lys Pro Cys Asp Ser Val Leu Arg 
            260                 265                 270         


Met Gln Lys Ser Val Val Ile Xaa Leu Ser Leu Ala Ala Ser Asn Cys 
        275                 280                 285             


Cys Phe Asp Pro Leu Leu Tyr Phe Phe Ser Gly Gly Asn Phe Arg Lys 
    290                 295                 300                 


Arg Leu Ser Xaa Phe Arg Lys His Ser Leu Ser Ser Val Xaa Tyr Val 
305                 310                 315                 320 


Pro Arg Lys Lys Ala Ser Leu Pro Glu Lys Gly Glu Glu Ile Cys Lys 
                325                 330                 335     


Val 
    


<210> 7476
<211> 15
<212> PRT
<213> Homo sapiens

<400> 7476
Met Glu Arg Lys Phe Met Ser Leu Gln Pro Ser Ile Ser Val Ser 
1               5                   10                  15  


<210> 7477
<211> 346
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<400> 7477
Met Glu Arg Lys Phe Met Ser Leu Gln Pro Ser Ile Ser Val Ser Glu 
1               5                   10                  15      


Met Glu Pro Asn Gly Xaa Phe Ser Asn Asn Asn Ser Arg Asn Cys Xaa 
            20                  25                  30          


Ile Glu Asn Phe Lys Arg Glu Phe Phe Pro Ile Val Tyr Leu Ile Ile 
        35                  40                  45              


Phe Phe Trp Gly Val Leu Gly Asn Gly Leu Ser Ile Tyr Val Phe Leu 
    50                  55                  60                  


Gln Pro Tyr Lys Lys Ser Xaa Ser Val Asn Val Phe Met Leu Asn Leu 
65                  70                  75                  80  


Ala Ile Ser Asp Leu Leu Phe Ile Ser Xaa Leu Pro Phe Arg Ala Asp 
                85                  90                  95      


Tyr Tyr Leu Arg Gly Ser Asn Trp Ile Phe Gly Asp Leu Ala Cys Arg 
            100                 105                 110         


Ile Met Ser Tyr Ser Leu Tyr Val Asn Met Tyr Ser Ser Ile Tyr Phe 
        115                 120                 125             


Leu Xaa Val Leu Ser Val Val Arg Phe Leu Ala Met Val His Pro Phe 
    130                 135                 140                 


Arg Leu Leu His Val Xaa Ser Ile Arg Ser Ala Trp Ile Leu Cys Gly 
145                 150                 155                 160 


Ile Ile Trp Ile Leu Ile Met Ala Ser Ser Ile Met Leu Leu Asp Ser 
                165                 170                 175     


Gly Ser Glu Gln Asn Gly Ser Val Xaa Ser Cys Leu Glu Leu Asn Leu 
            180                 185                 190         


Tyr Lys Ile Ala Lys Leu Gln Xaa Met Asn Tyr Ile Ala Leu Val Val 
        195                 200                 205             


Gly Cys Leu Leu Pro Phe Phe Xaa Leu Ser Ile Cys Tyr Leu Leu Ile 
    210                 215                 220                 


Ile Arg Val Leu Leu Lys Val Glu Val Pro Glu Ser Gly Leu Arg Val 
225                 230                 235                 240 


Ser His Arg Lys Ala Leu Xaa Xaa Ile Ile Ile Xaa Leu Ile Ile Phe 
                245                 250                 255     


Phe Leu Cys Phe Leu Pro Tyr His Xaa Leu Arg Xaa Val His Leu Xaa 
            260                 265                 270         


Xaa Trp Lys Val Gly Leu Cys Lys Asp Arg Leu His Lys Ala Leu Val 
        275                 280                 285             


Ile Xaa Leu Ala Leu Ala Ala Ala Asn Ala Cys Phe Asn Pro Leu Leu 
    290                 295                 300                 


Tyr Tyr Phe Ala Gly Glu Asn Phe Lys Asp Arg Leu Lys Ser Ala Leu 
305                 310                 315                 320 


Arg Lys Gly His Pro Gln Lys Ala Lys Xaa Lys Cys Val Phe Pro Val 
                325                 330                 335     


Ser Val Trp Leu Arg Lys Glu Xaa Arg Val 
            340                 345     


<210> 7478
<211> 11
<212> PRT
<213> Homo sapiens

<400> 7478
Met Glu Glu Asp Asp Ser Tyr Glu Ala Glu Gly 
1               5                   10      


<210> 7479
<211> 397
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<400> 7479
Met Glu Glu Asp Asp Ser Tyr Val Pro Ser Asp Leu Xaa Ala Glu Glu 
1               5                   10                  15      


Arg Gln Glu Leu Glu Asn Ile Arg Arg Arg Lys Gln Glu Leu Leu Ala 
            20                  25                  30          


Asp Ile Gln Arg Leu Lys Asp Glu Ile Ala Glu Val Ala Asn Glu Ile 
        35                  40                  45              


Glu Asn Leu Gly Ser Xaa Glu Glu Arg Lys Asn Met Gln Arg Asn Lys 
    50                  55                  60                  


Gln Val Ala Met Gly Arg Lys Lys Phe Asn Met Asp Pro Lys Lys Gly 
65                  70                  75                  80  


Ile Gln Phe Leu Ile Glu Asn Asp Leu Leu Lys Asn Xaa Cys Glu Asp 
                85                  90                  95      


Ile Ala Gln Phe Leu Tyr Lys Gly Glu Gly Leu Asn Lys Xaa Ala Ile 
            100                 105                 110         


Gly Asp Tyr Leu Gly Glu Arg Asp Glu Phe Asn Ile Gln Val Leu His 
        115                 120                 125             


Ala Phe Val Glu Leu His Glu Phe Xaa Asp Leu Asn Leu Val Gln Ala 
    130                 135                 140                 


Leu Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly Glu Ala Gln Lys 
145                 150                 155                 160 


Ile Asp Arg Met Met Glu Ala Phe Ala Gln Arg Tyr Cys Gln Cys Asn 
                165                 170                 175     


Asn Gly Val Phe Gln Ser Xaa Asp Xaa Cys Tyr Val Leu Ser Phe Ala 
            180                 185                 190         


Ile Ile Met Leu Asn Xaa Ser Leu His Asn Pro Asn Val Lys Asp Lys 
        195                 200                 205             


Pro Xaa Val Glu Arg Phe Ile Ala Met Asn Arg Gly Ile Asn Asp Gly 
    210                 215                 220                 


Gly Asp Leu Pro Glu Glu Leu Leu Arg Asn Leu Tyr Glu Ser Ile Lys 
225                 230                 235                 240 


Asn Glu Pro Phe Lys Ile Pro Glu Asp Asp Gly Asn Asp Leu Xaa His 
                245                 250                 255     


Xaa Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu Lys Leu Gly Gly 
            260                 265                 270         


Arg Val Lys Xaa Trp Lys Arg Arg Trp Phe Ile Leu Xaa Asp Asn Cys 
        275                 280                 285             


Leu Tyr Tyr Phe Glu Tyr Xaa Xaa Asp Lys Glu Pro Arg Gly Ile Ile 
    290                 295                 300                 


Pro Leu Glu Asn Leu Ser Ile Arg Glu Val Glu Asp Ser Lys Lys Pro 
305                 310                 315                 320 


Asn Cys Phe Glu Leu Tyr Ile Pro Asp Asn Lys Asp Gln Val Ile Lys 
                325                 330                 335     


Ala Cys Lys Xaa Glu Ala Asp Gly Arg Val Val Glu Gly Asn His Xaa 
            340                 345                 350         


Val Tyr Arg Ile Ser Ala Pro Xaa Pro Glu Glu Lys Glu Glu Trp Ile 
        355                 360                 365             


Lys Cys Ile Lys Ala Ala Ile Ser Arg Asp Pro Phe Tyr Glu Met Leu 
    370                 375                 380                 


Ala Ala Arg Lys Lys Lys Val Ser Ser Xaa Lys Arg His 
385                 390                 395         


<210> 7480
<211> 398
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<400> 7480
Met Glu Glu Asp Asp Ser Tyr Val Pro Ser Asp Leu Xaa Ala Glu Glu 
1               5                   10                  15      


Arg Gln Glu Leu Glu Asn Ile Arg Arg Arg Lys Gln Glu Leu Leu Ala 
            20                  25                  30          


Asp Ile Gln Arg Leu Lys Asp Glu Ile Ala Glu Val Ala Asn Glu Ile 
        35                  40                  45              


Glu Asn Leu Gly Ser Xaa Glu Glu Arg Lys Asn Met Gln Arg Asn Lys 
    50                  55                  60                  


Gln Val Ala Met Gly Arg Lys Lys Phe Asn Met Asp Pro Lys Lys Gly 
65                  70                  75                  80  


Ile Gln Phe Leu Ile Glu Asn Asp Leu Leu Lys Asn Xaa Cys Glu Asp 
                85                  90                  95      


Ile Ala Gln Phe Leu Tyr Lys Gly Glu Gly Leu Asn Lys Xaa Ala Ile 
            100                 105                 110         


Gly Asp Tyr Leu Gly Glu Arg Asp Glu Phe Asn Ile Gln Val Leu His 
        115                 120                 125             


Ala Phe Val Glu Leu His Glu Phe Xaa Asp Leu Asn Leu Val Gln Ala 
    130                 135                 140                 


Leu Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly Glu Ala Gln Lys 
145                 150                 155                 160 


Ile Asp Arg Met Met Glu Ala Phe Ala Gln Arg Tyr Cys Gln Cys Asn 
                165                 170                 175     


Asn Gly Val Phe Gln Ser Xaa Asp Xaa Cys Tyr Val Leu Ser Phe Ala 
            180                 185                 190         


Ile Ile Met Leu Asn Xaa Ser Leu His Asn Pro Asn Val Lys Asp Lys 
        195                 200                 205             


Pro Xaa Val Glu Arg Phe Ile Ala Met Asn Arg Gly Ile Asn Asp Gly 
    210                 215                 220                 


Gly Asp Leu Pro Glu Glu Leu Leu Arg Asn Leu Tyr Glu Ser Ile Lys 
225                 230                 235                 240 


Asn Glu Pro Phe Lys Ile Pro Glu Asp Asp Gly Asn Asp Leu Xaa His 
                245                 250                 255     


Xaa Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu Lys Leu Gly Gly 
            260                 265                 270         


Gly Arg Val Lys Xaa Trp Lys Arg Arg Trp Phe Ile Leu Xaa Asp Asn 
        275                 280                 285             


Cys Leu Tyr Tyr Phe Glu Tyr Xaa Xaa Asp Lys Glu Pro Arg Gly Ile 
    290                 295                 300                 


Ile Pro Leu Glu Asn Leu Ser Ile Arg Glu Val Glu Asp Ser Lys Lys 
305                 310                 315                 320 


Pro Asn Cys Phe Glu Leu Tyr Ile Pro Asp Asn Lys Asp Gln Val Ile 
                325                 330                 335     


Lys Ala Cys Lys Xaa Glu Ala Asp Gly Arg Val Val Glu Gly Asn His 
            340                 345                 350         


Xaa Val Tyr Arg Ile Ser Ala Pro Xaa Pro Glu Glu Lys Glu Glu Trp 
        355                 360                 365             


Ile Lys Cys Ile Lys Ala Ala Ile Ser Arg Asp Pro Phe Tyr Glu Met 
    370                 375                 380                 


Leu Ala Ala Arg Lys Lys Lys Val Ser Ser Xaa Lys Arg His 
385                 390                 395             


<210> 7481
<211> 64
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<400> 7481
Met Glu Glu Asp Asp Ser Tyr Val Pro Ser Asp Leu Xaa Ala Glu Glu 
1               5                   10                  15      


Arg Gln Glu Leu Glu Asn Ile Arg Arg Arg Lys Gln Glu Leu Leu Ala 
            20                  25                  30          


Asp Ile Gln Arg Leu Lys Asp Glu Ile Ala Glu Val Ala Asn Glu Ile 
        35                  40                  45              


Glu Asn Leu Gly Ser Xaa Glu Glu Ser Phe Ser Phe Cys Tyr Phe Phe 
    50                  55                  60                  


<210> 7482
<211> 194
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Selenocysteine

<400> 7482
Met His Ser Pro Gly Gly Leu Gly Arg Pro Cys Leu Leu Gln Pro Cys 
1               5                   10                  15      


Pro Ala Val Pro Ser Asp Leu Xaa Ala Glu Glu Arg Gln Glu Leu Glu 
            20                  25                  30          


Asn Ile Arg Arg Arg Lys Gln Glu Leu Leu Ala Asp Ile Gln Arg Leu 
        35                  40                  45              


Lys Asp Glu Ile Ala Glu Val Ala Asn Glu Ile Glu Asn Leu Gly Ser 
    50                  55                  60                  


Xaa Glu Glu Arg Lys Asn Met Gln Arg Asn Lys Gln Val Ala Met Gly 
65                  70                  75                  80  


Arg Lys Lys Phe Asn Met Asp Pro Lys Lys Gly Ile Gln Phe Leu Ile 
                85                  90                  95      


Glu Asn Asp Leu Leu Lys Asn Xaa Cys Glu Asp Ile Ala Gln Phe Leu 
            100                 105                 110         


Tyr Lys Gly Glu Gly Leu Asn Lys Xaa Ala Ile Gly Asp Tyr Leu Gly 
        115                 120                 125             


Glu Arg Asp Glu Phe Asn Ile Gln Val Leu His Ala Phe Val Glu Leu 
    130                 135                 140                 


His Glu Phe Xaa Asp Leu Asn Leu Val Gln Ala Leu Arg Gln Phe Leu 
145                 150                 155                 160 


Trp Ser Phe Arg Leu Pro Gly Glu Ala Gln Lys Ile Asp Arg Met Met 
                165                 170                 175     


Glu Ala Phe Ala Gln Arg Tyr Cys Gln Cys Asn Asn Gly Val Phe Gln 
            180                 185                 190         


Ser Xaa 
        


<210> 7483
<211> 86
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 7483
Met Gln Arg Asn Lys Gln Val Ala Met Gly Arg Lys Lys Phe Asn Met 
1               5                   10                  15      


Asp Pro Lys Lys Gly Ile Gln Phe Leu Ile Glu Asn Asp Leu Leu Lys 
            20                  25                  30          


Asn Xaa Cys Glu Asp Ile Ala Gln Phe Leu Tyr Lys Gly Glu Gly Leu 
        35                  40                  45              


Asn Lys Xaa Ala Ile Gly Asp Tyr Leu Gly Glu Arg Asp Glu Phe Asn 
    50                  55                  60                  


Ile Gln Val Leu His Ala Phe Val Glu Leu His Glu Phe Xaa Asp Leu 
65                  70                  75                  80  


Asn Leu Val Gln Ala Leu 
                85      


<210> 7484
<211> 104
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 7484
Met Gln Arg Asn Lys Gln Val Ala Met Gly Arg Lys Lys Phe Asn Met 
1               5                   10                  15      


Asp Pro Lys Lys Gly Ile Gln Phe Leu Ile Glu Asn Asp Leu Leu Lys 
            20                  25                  30          


Asn Xaa Cys Glu Asp Ile Ala Gln Phe Leu Tyr Lys Gly Glu Gly Leu 
        35                  40                  45              


Asn Lys Xaa Ala Ile Gly Asp Tyr Leu Gly Glu Arg Asp Glu Phe Asn 
    50                  55                  60                  


Ile Gln Val Leu His Ala Phe Val Glu Leu His Glu Phe Xaa Asp Leu 
65                  70                  75                  80  


Asn Leu Val Gln Ala Leu Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro 
                85                  90                  95      


Gly Glu Ala Gln Lys Ile Asp Arg 
            100                 


<210> 7485
<211> 339
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<400> 7485
Met Gln Arg Asn Lys Gln Val Ala Met Gly Arg Lys Lys Phe Asn Met 
1               5                   10                  15      


Asp Pro Lys Lys Gly Ile Gln Phe Leu Ile Glu Asn Asp Leu Leu Lys 
            20                  25                  30          


Asn Xaa Cys Glu Asp Ile Ala Gln Phe Leu Tyr Lys Gly Glu Gly Leu 
        35                  40                  45              


Asn Lys Xaa Ala Ile Gly Asp Tyr Leu Gly Glu Arg Asp Glu Phe Asn 
    50                  55                  60                  


Ile Gln Val Leu His Ala Phe Val Glu Leu His Glu Phe Xaa Asp Leu 
65                  70                  75                  80  


Asn Leu Val Gln Ala Leu Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro 
                85                  90                  95      


Gly Glu Ala Gln Lys Ile Asp Arg Met Met Glu Ala Phe Ala Gln Arg 
            100                 105                 110         


Tyr Cys Gln Cys Asn Asn Gly Val Phe Gln Ser Xaa Asp Xaa Cys Tyr 
        115                 120                 125             


Val Leu Ser Phe Ala Ile Ile Met Leu Asn Xaa Ser Leu His Asn Pro 
    130                 135                 140                 


Asn Val Lys Asp Lys Pro Xaa Val Glu Arg Phe Ile Ala Met Asn Arg 
145                 150                 155                 160 


Gly Ile Asn Asp Gly Gly Asp Leu Pro Glu Glu Leu Leu Arg Asn Leu 
                165                 170                 175     


Tyr Glu Ser Ile Lys Asn Glu Pro Phe Lys Ile Pro Glu Asp Asp Gly 
            180                 185                 190         


Asn Asp Leu Xaa His Xaa Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu 
        195                 200                 205             


Leu Lys Leu Gly Gly Gly Arg Val Lys Xaa Trp Lys Arg Arg Trp Phe 
    210                 215                 220                 


Ile Leu Xaa Asp Asn Cys Leu Tyr Tyr Phe Glu Tyr Xaa Xaa Asp Lys 
225                 230                 235                 240 


Glu Pro Arg Gly Ile Ile Pro Leu Glu Asn Leu Ser Ile Arg Glu Val 
                245                 250                 255     


Glu Asp Ser Lys Lys Pro Asn Cys Phe Glu Leu Tyr Ile Pro Asp Asn 
            260                 265                 270         


Lys Asp Gln Val Ile Lys Ala Cys Lys Xaa Glu Ala Asp Gly Arg Val 
        275                 280                 285             


Val Glu Gly Asn His Xaa Val Tyr Arg Ile Ser Ala Pro Xaa Pro Glu 
    290                 295                 300                 


Glu Lys Glu Glu Trp Ile Lys Cys Ile Lys Ala Ala Ile Ser Arg Asp 
305                 310                 315                 320 


Pro Phe Tyr Glu Met Leu Ala Ala Arg Lys Lys Lys Val Ser Ser Xaa 
                325                 330                 335     


Lys Arg His 
            


<210> 7486
<211> 272
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<400> 7486
Met Val Leu Lys Xaa Glu Glu Glu Asp Val Pro Ser Asp Leu Xaa Ala 
1               5                   10                  15      


Glu Glu Arg Gln Glu Leu Glu Asn Ile Arg Arg Arg Lys Gln Glu Leu 
            20                  25                  30          


Leu Ala Asp Ile Gln Arg Leu Lys Asp Glu Ile Ala Glu Val Ala Asn 
        35                  40                  45              


Glu Ile Glu Asn Leu Gly Ser Xaa Glu Glu Arg Lys Asn Met Gln Arg 
    50                  55                  60                  


Asn Lys Gln Val Ala Met Gly Arg Lys Lys Phe Asn Met Asp Pro Lys 
65                  70                  75                  80  


Lys Gly Ile Gln Phe Leu Ile Glu Asn Asp Leu Leu Lys Asn Xaa Cys 
                85                  90                  95      


Glu Asp Ile Ala Gln Phe Leu Tyr Lys Gly Glu Gly Leu Asn Lys Xaa 
            100                 105                 110         


Ala Ile Gly Asp Tyr Leu Gly Glu Arg Asp Glu Phe Asn Ile Gln Val 
        115                 120                 125             


Leu His Ala Phe Val Glu Leu His Glu Phe Xaa Asp Leu Asn Leu Val 
    130                 135                 140                 


Gln Ala Leu Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly Glu Ala 
145                 150                 155                 160 


Gln Lys Ile Asp Arg Met Met Glu Ala Phe Ala Gln Arg Tyr Cys Gln 
                165                 170                 175     


Cys Asn Asn Gly Val Phe Gln Ser Xaa Asp Xaa Cys Tyr Val Leu Ser 
            180                 185                 190         


Phe Ala Ile Ile Met Leu Asn Xaa Ser Leu His Asn Pro Asn Val Lys 
        195                 200                 205             


Asp Lys Pro Xaa Val Glu Arg Phe Ile Ala Met Asn Arg Gly Ile Asn 
    210                 215                 220                 


Asp Gly Gly Asp Leu Pro Glu Glu Leu Leu Arg Asn Leu Tyr Glu Ser 
225                 230                 235                 240 


Ile Lys Asn Glu Pro Phe Lys Ile Pro Glu Asp Asp Gly Asn Asp Leu 
                245                 250                 255     


Xaa His Xaa Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu Lys Leu 
            260                 265                 270         


<210> 7487
<211> 214
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (110)..(110)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (210)..(210)
<223> Selenocysteine

<400> 7487
Leu Leu Gln Asn Xaa Pro Glu Glu Ile Ala Arg Phe Leu Tyr Lys Gly 
1               5                   10                  15      


Glu Gly Leu Asn Lys Xaa Ala Ile Gly Asp Tyr Leu Gly Glu Arg Glu 
            20                  25                  30          


Glu Leu Asn Leu Ala Val Leu His Ala Phe Val Asp Leu His Glu Phe 
        35                  40                  45              


Xaa Asp Leu Asn Leu Val Gln Ala Leu Arg Gln Phe Leu Trp Ser Phe 
    50                  55                  60                  


Arg Leu Pro Gly Glu Ala Gln Lys Ile Asp Arg Met Met Glu Ala Phe 
65                  70                  75                  80  


Ala Gln Arg Tyr Cys Leu Cys Asn Pro Gly Val Phe Gln Ser Xaa Asp 
                85                  90                  95      


Xaa Cys Tyr Val Leu Ser Phe Ala Val Ile Met Leu Asn Xaa Ser Leu 
            100                 105                 110         


His Asn Pro Asn Val Arg Asp Lys Pro Gly Leu Glu Arg Phe Val Ala 
        115                 120                 125             


Met Asn Arg Gly Ile Asn Glu Gly Gly Asp Leu Pro Glu Glu Leu Leu 
    130                 135                 140                 


Arg Asn Leu Tyr Asp Ser Ile Arg Asn Glu Pro Phe Lys Ile Pro Glu 
145                 150                 155                 160 


Asp Asp Gly Asn Asp Leu Xaa His Xaa Phe Phe Asn Pro Asp Arg Glu 
                165                 170                 175     


Gly Trp Leu Leu Lys Leu Gly Xaa Cys Pro Pro Asp Pro Ala Gly Pro 
            180                 185                 190         


Ser Ala Gly Gly His Leu Trp Ala Trp Ala Leu Asp Ser Ala Ser Ala 
        195                 200                 205             


His Xaa Cys Cys Leu Asn 
    210                 


<210> 7488
<211> 254
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (206)..(206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<400> 7488
Met Asp Pro Val Val Arg Ile Xaa Arg Ser Pro Ala Xaa Ser Pro Val 
1               5                   10                  15      


Met Glu Ser Glu Asn Gln Gly Leu Ser Pro Leu Pro Lys Pro Pro Asp 
            20                  25                  30          


Leu Xaa Pro Glu Glu Arg Met Glu Leu Glu Asn Ile Arg Arg Arg Lys 
        35                  40                  45              


Gln Glu Leu Leu Val Glu Ile Gln Arg Leu Arg Glu Glu Leu Ser Glu 
    50                  55                  60                  


Ala Met Ser Glu Val Glu Gly Leu Glu Ala Asn Glu Gly Ser Lys Xaa 
65                  70                  75                  80  


Leu Gln Arg Asn Arg Lys Met Ala Met Gly Arg Lys Lys Phe Asn Met 
                85                  90                  95      


Asp Pro Lys Lys Gly Ile Gln Phe Leu Val Glu Asn Glu Leu Leu Gln 
            100                 105                 110         


Asn Xaa Pro Glu Glu Ile Ala Arg Phe Leu Tyr Lys Gly Glu Gly Leu 
        115                 120                 125             


Asn Lys Xaa Ala Ile Gly Asp Tyr Leu Gly Glu Arg Glu Glu Leu Asn 
    130                 135                 140                 


Leu Ala Val Leu His Ala Phe Val Asp Leu His Glu Phe Xaa Asp Leu 
145                 150                 155                 160 


Asn Leu Val Gln Ala Leu Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro 
                165                 170                 175     


Gly Glu Ala Gln Lys Ile Asp Arg Met Met Glu Ala Phe Ala Gln Arg 
            180                 185                 190         


Tyr Cys Leu Cys Asn Pro Gly Val Phe Gln Ser Xaa Asp Xaa Cys Tyr 
        195                 200                 205             


Val Leu Ser Phe Ala Val Ile Met Leu Asn Xaa Ser Leu His Asn Pro 
    210                 215                 220                 


Asn Val Arg Asp Lys Pro Gly Leu Glu Arg Phe Val Ala Met Asn Arg 
225                 230                 235                 240 


Gly Ile Asn Glu Gly Gly Asp Leu Pro Glu Glu Leu Leu Arg 
                245                 250                 


<210> 7489
<211> 292
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<400> 7489
Met Glu Asp Gly Val Tyr Glu Pro Pro Asp Leu Xaa Pro Glu Glu Arg 
1               5                   10                  15      


Met Glu Leu Glu Asn Ile Arg Arg Arg Lys Gln Glu Leu Leu Val Glu 
            20                  25                  30          


Ile Gln Arg Leu Arg Glu Glu Leu Ser Glu Ala Met Ser Glu Val Glu 
        35                  40                  45              


Gly Leu Glu Ala Asn Glu Gly Ser Lys Xaa Leu Gln Arg Asn Arg Lys 
    50                  55                  60                  


Met Ala Met Gly Arg Lys Lys Phe Asn Met Asp Pro Lys Lys Gly Ile 
65                  70                  75                  80  


Gln Phe Leu Val Glu Asn Glu Leu Leu Gln Asn Xaa Pro Glu Glu Ile 
                85                  90                  95      


Ala Arg Phe Leu Tyr Lys Gly Glu Gly Leu Asn Lys Xaa Ala Ile Gly 
            100                 105                 110         


Asp Tyr Leu Gly Glu Arg Glu Glu Leu Asn Leu Ala Val Leu His Ala 
        115                 120                 125             


Phe Val Asp Leu His Glu Phe Xaa Asp Leu Asn Leu Val Gln Ala Leu 
    130                 135                 140                 


Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly Glu Ala Gln Lys Ile 
145                 150                 155                 160 


Asp Arg Met Met Glu Ala Phe Ala Gln Arg Tyr Cys Leu Cys Asn Pro 
                165                 170                 175     


Gly Val Phe Gln Ser Xaa Asp Xaa Cys Tyr Val Leu Ser Phe Ala Val 
            180                 185                 190         


Ile Met Leu Asn Xaa Ser Leu His Asn Pro Asn Val Arg Asp Lys Pro 
        195                 200                 205             


Gly Leu Glu Arg Phe Val Ala Met Asn Arg Gly Ile Asn Glu Gly Gly 
    210                 215                 220                 


Asp Leu Pro Glu Glu Leu Leu Arg Asn Leu Tyr Asp Ser Ile Arg Asn 
225                 230                 235                 240 


Glu Pro Phe Lys Ile Pro Glu Asp Asp Gly Asn Asp Leu Xaa His Xaa 
                245                 250                 255     


Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu Lys Leu Gly Xaa Gly 
            260                 265                 270         


Pro Gly Glu Asp Val Glu Ala Ala Leu Val Tyr Pro His Arg Gln Leu 
        275                 280                 285             


Pro Leu Leu Leu 
    290         


<210> 7490
<211> 399
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Selenocysteine

<400> 7490
Met Glu Asp Gly Val Tyr Glu Pro Pro Asp Leu Xaa Pro Glu Glu Arg 
1               5                   10                  15      


Met Glu Leu Glu Asn Ile Arg Arg Arg Lys Gln Glu Leu Leu Val Glu 
            20                  25                  30          


Ile Gln Arg Leu Arg Glu Glu Leu Ser Glu Ala Met Ser Glu Val Glu 
        35                  40                  45              


Gly Leu Glu Ala Asn Glu Gly Ser Lys Xaa Leu Gln Arg Asn Arg Lys 
    50                  55                  60                  


Met Ala Met Gly Arg Lys Lys Phe Asn Met Asp Pro Lys Lys Gly Ile 
65                  70                  75                  80  


Gln Phe Leu Val Glu Asn Glu Leu Leu Gln Asn Xaa Pro Glu Glu Ile 
                85                  90                  95      


Ala Arg Phe Leu Tyr Lys Gly Glu Gly Leu Asn Lys Xaa Ala Ile Gly 
            100                 105                 110         


Asp Tyr Leu Gly Glu Arg Glu Glu Leu Asn Leu Ala Val Leu His Ala 
        115                 120                 125             


Phe Val Asp Leu His Glu Phe Xaa Asp Leu Asn Leu Val Gln Ala Leu 
    130                 135                 140                 


Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly Glu Ala Gln Lys Ile 
145                 150                 155                 160 


Asp Arg Met Met Glu Ala Phe Ala Gln Arg Tyr Cys Leu Cys Asn Pro 
                165                 170                 175     


Gly Val Phe Gln Ser Xaa Asp Xaa Cys Tyr Val Leu Ser Phe Ala Val 
            180                 185                 190         


Ile Met Leu Asn Xaa Ser Leu His Asn Pro Asn Val Arg Asp Lys Pro 
        195                 200                 205             


Gly Leu Glu Arg Phe Val Ala Met Asn Arg Gly Ile Asn Glu Gly Gly 
    210                 215                 220                 


Asp Leu Pro Glu Glu Leu Leu Arg Asn Leu Tyr Asp Ser Ile Arg Asn 
225                 230                 235                 240 


Glu Pro Phe Lys Ile Pro Glu Asp Asp Gly Asn Asp Leu Xaa His Xaa 
                245                 250                 255     


Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu Lys Leu Gly Gly Arg 
            260                 265                 270         


Val Lys Xaa Trp Lys Arg Arg Trp Phe Ile Leu Xaa Asp Asn Cys Leu 
        275                 280                 285             


Tyr Tyr Phe Glu Tyr Xaa Xaa Asp Lys Glu Pro Arg Gly Ile Ile Pro 
    290                 295                 300                 


Leu Glu Asn Leu Ser Ile Arg Glu Val Asp Asp Pro Arg Lys Pro Asn 
305                 310                 315                 320 


Cys Phe Glu Leu Tyr Ile Pro Asn Asn Lys Gly Gln Leu Ile Lys Ala 
                325                 330                 335     


Cys Lys Xaa Glu Ala Asp Gly Arg Val Val Glu Gly Asn His Met Val 
            340                 345                 350         


Tyr Arg Ile Ser Ala Pro Xaa Gln Glu Glu Lys Asp Glu Trp Ile Lys 
        355                 360                 365             


Ser Ile Gln Ala Ala Val Ser Val Asp Pro Phe Tyr Glu Met Leu Ala 
    370                 375                 380                 


Ala Arg Lys Lys Arg Ile Ser Val Lys Lys Lys Gln Glu Gln Pro 
385                 390                 395                 


<210> 7491
<211> 400
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<400> 7491
Met Glu Asp Gly Val Tyr Glu Pro Pro Asp Leu Xaa Pro Glu Glu Arg 
1               5                   10                  15      


Met Glu Leu Glu Asn Ile Arg Arg Arg Lys Gln Glu Leu Leu Val Glu 
            20                  25                  30          


Ile Gln Arg Leu Arg Glu Glu Leu Ser Glu Ala Met Ser Glu Val Glu 
        35                  40                  45              


Gly Leu Glu Ala Asn Glu Gly Ser Lys Xaa Leu Gln Arg Asn Arg Lys 
    50                  55                  60                  


Met Ala Met Gly Arg Lys Lys Phe Asn Met Asp Pro Lys Lys Gly Ile 
65                  70                  75                  80  


Gln Phe Leu Val Glu Asn Glu Leu Leu Gln Asn Xaa Pro Glu Glu Ile 
                85                  90                  95      


Ala Arg Phe Leu Tyr Lys Gly Glu Gly Leu Asn Lys Xaa Ala Ile Gly 
            100                 105                 110         


Asp Tyr Leu Gly Glu Arg Glu Glu Leu Asn Leu Ala Val Leu His Ala 
        115                 120                 125             


Phe Val Asp Leu His Glu Phe Xaa Asp Leu Asn Leu Val Gln Ala Leu 
    130                 135                 140                 


Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly Glu Ala Gln Lys Ile 
145                 150                 155                 160 


Asp Arg Met Met Glu Ala Phe Ala Gln Arg Tyr Cys Leu Cys Asn Pro 
                165                 170                 175     


Gly Val Phe Gln Ser Xaa Asp Xaa Cys Tyr Val Leu Ser Phe Ala Val 
            180                 185                 190         


Ile Met Leu Asn Xaa Ser Leu His Asn Pro Asn Val Arg Asp Lys Pro 
        195                 200                 205             


Gly Leu Glu Arg Phe Val Ala Met Asn Arg Gly Ile Asn Glu Gly Gly 
    210                 215                 220                 


Asp Leu Pro Glu Glu Leu Leu Arg Asn Leu Tyr Asp Ser Ile Arg Asn 
225                 230                 235                 240 


Glu Pro Phe Lys Ile Pro Glu Asp Asp Gly Asn Asp Leu Xaa His Xaa 
                245                 250                 255     


Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu Lys Leu Ala Gly Gly 
            260                 265                 270         


Arg Val Lys Xaa Trp Lys Arg Arg Trp Phe Ile Leu Xaa Asp Asn Cys 
        275                 280                 285             


Leu Tyr Tyr Phe Glu Tyr Xaa Xaa Asp Lys Glu Pro Arg Gly Ile Ile 
    290                 295                 300                 


Pro Leu Glu Asn Leu Ser Ile Arg Glu Val Asp Asp Pro Arg Lys Pro 
305                 310                 315                 320 


Asn Cys Phe Glu Leu Tyr Ile Pro Asn Asn Lys Gly Gln Leu Ile Lys 
                325                 330                 335     


Ala Cys Lys Xaa Glu Ala Asp Gly Arg Val Val Glu Gly Asn His Met 
            340                 345                 350         


Val Tyr Arg Ile Ser Ala Pro Xaa Gln Glu Glu Lys Asp Glu Trp Ile 
        355                 360                 365             


Lys Ser Ile Gln Ala Ala Val Ser Val Asp Pro Phe Tyr Glu Met Leu 
    370                 375                 380                 


Ala Ala Arg Lys Lys Arg Ile Ser Val Lys Lys Lys Gln Glu Gln Pro 
385                 390                 395                 400 


<210> 7492
<211> 139
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<400> 7492
Met Val Ala Pro Leu Gln Ser Ser Leu Gly Asn Arg Ala Arg Pro Arg 
1               5                   10                  15      


Leu Tyr Lys Ile Lys His Ala Asn His Cys Pro Ala Asn Xaa Pro Val 
            20                  25                  30          


Gln Ile Pro Ala Phe Asp Pro Arg Glu Ala Asp Cys Trp Gly Lys Leu 
        35                  40                  45              


Arg Val Leu Glu Val Pro Leu Ala Val Ser Gly Gln Lys Glu Lys Gln 
    50                  55                  60                  


Glu Gly Ala Ser Ile Xaa Arg Asn Cys Phe Pro Gln Ser Ala Gly Ile 
65                  70                  75                  80  


Xaa Gly Val Ser His Arg Ala Arg Pro Gln Pro Xaa Ser Phe Gly Trp 
                85                  90                  95      


Gln Trp Phe Gly Tyr Arg Leu Ser Ser Leu Lys Phe Met Leu Arg Phe 
            100                 105                 110         


Glu Pro Gln Cys Gly Arg Cys Trp Asp Val Gly Pro His Arg Ser Cys 
        115                 120                 125             


Val Val Leu Glu Val Glu Ser Ser Trp Ile Asp 
    130                 135                 


<210> 7493
<211> 399
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Selenocysteine

<400> 7493
Met Asp Glu Asp Gly Gly Gly Glu Gly Gly Gly Val Pro Glu Asp Leu 
1               5                   10                  15      


Ser Leu Glu Glu Arg Glu Glu Leu Leu Asp Ile Arg Arg Arg Lys Lys 
            20                  25                  30          


Glu Leu Ile Asp Asp Ile Glu Arg Leu Lys Tyr Glu Ile Ala Glu Val 
        35                  40                  45              


Met Xaa Glu Ile Asp Asn Leu Xaa Ser Val Glu Glu Ser Lys Xaa Xaa 
    50                  55                  60                  


Gln Arg Asn Lys Gln Ile Ala Met Gly Arg Lys Lys Phe Asn Met Asp 
65                  70                  75                  80  


Pro Lys Lys Gly Ile Gln Phe Leu Ile Glu Asn Asp Leu Leu Gln Ser 
                85                  90                  95      


Ser Pro Glu Asp Val Ala Gln Phe Leu Tyr Lys Gly Glu Gly Leu Asn 
            100                 105                 110         


Lys Xaa Val Ile Gly Asp Tyr Leu Gly Glu Arg Asp Glu Phe Asn Ile 
        115                 120                 125             


Lys Val Leu Gln Ala Phe Val Glu Leu His Glu Phe Ala Asp Leu Asn 
    130                 135                 140                 


Leu Val Gln Ala Leu Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly 
145                 150                 155                 160 


Glu Ala Gln Lys Ile Asp Arg Met Met Glu Ala Phe Ala Ser Arg Tyr 
                165                 170                 175     


Cys Leu Cys Asn Pro Gly Val Phe Gln Ser Xaa Asp Xaa Cys Tyr Val 
            180                 185                 190         


Leu Ser Phe Ala Ile Ile Met Leu Asn Xaa Ser Leu His Asn His Asn 
        195                 200                 205             


Val Arg Asp Lys Pro Xaa Ala Glu Arg Phe Ile Ala Met Asn Arg Gly 
    210                 215                 220                 


Ile Asn Glu Gly Gly Asp Leu Pro Glu Glu Leu Leu Arg Asn Leu Tyr 
225                 230                 235                 240 


Glu Ser Ile Lys Asn Glu Pro Phe Lys Ile Pro Glu Asp Asp Gly Asn 
                245                 250                 255     


Asp Leu Xaa His Xaa Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu 
            260                 265                 270         


Lys Leu Gly Gly Arg Val Lys Xaa Trp Lys Arg Arg Trp Phe Ile Leu 
        275                 280                 285             


Xaa Asp Asn Cys Leu Tyr Tyr Phe Glu Tyr Xaa Xaa Asp Lys Glu Pro 
    290                 295                 300                 


Arg Gly Ile Ile Pro Leu Glu Asn Leu Ser Ile Arg Glu Val Glu Asp 
305                 310                 315                 320 


Pro Arg Lys Pro Asn Cys Phe Glu Leu Tyr Asn Pro Ser His Lys Gly 
                325                 330                 335     


Gln Val Ile Lys Ala Cys Lys Xaa Glu Ala Asp Gly Arg Val Val Glu 
            340                 345                 350         


Gly Asn His Val Val Tyr Arg Ile Ser Ala Pro Ser Pro Glu Glu Lys 
        355                 360                 365             


Glu Glu Trp Met Lys Ser Ile Lys Ala Ser Ile Ser Arg Asp Pro Phe 
    370                 375                 380                 


Tyr Asp Met Leu Ala Xaa Arg Lys Arg Arg Ile Ala Asn Lys Lys 
385                 390                 395                 


<210> 7494
<211> 400
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<400> 7494
Met Asp Glu Asp Gly Gly Gly Glu Gly Gly Gly Val Pro Glu Asp Leu 
1               5                   10                  15      


Ser Leu Glu Glu Arg Glu Glu Leu Leu Asp Ile Arg Arg Arg Lys Lys 
            20                  25                  30          


Glu Leu Ile Asp Asp Ile Glu Arg Leu Lys Tyr Glu Ile Ala Glu Val 
        35                  40                  45              


Met Xaa Glu Ile Asp Asn Leu Xaa Ser Val Glu Glu Ser Lys Xaa Xaa 
    50                  55                  60                  


Gln Arg Asn Lys Gln Ile Ala Met Gly Arg Lys Lys Phe Asn Met Asp 
65                  70                  75                  80  


Pro Lys Lys Gly Ile Gln Phe Leu Ile Glu Asn Asp Leu Leu Gln Ser 
                85                  90                  95      


Ser Pro Glu Asp Val Ala Gln Phe Leu Tyr Lys Gly Glu Gly Leu Asn 
            100                 105                 110         


Lys Xaa Val Ile Gly Asp Tyr Leu Gly Glu Arg Asp Glu Phe Asn Ile 
        115                 120                 125             


Lys Val Leu Gln Ala Phe Val Glu Leu His Glu Phe Ala Asp Leu Asn 
    130                 135                 140                 


Leu Val Gln Ala Leu Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly 
145                 150                 155                 160 


Glu Ala Gln Lys Ile Asp Arg Met Met Glu Ala Phe Ala Ser Arg Tyr 
                165                 170                 175     


Cys Leu Cys Asn Pro Gly Val Phe Gln Ser Xaa Asp Xaa Cys Tyr Val 
            180                 185                 190         


Leu Ser Phe Ala Ile Ile Met Leu Asn Xaa Ser Leu His Asn His Asn 
        195                 200                 205             


Val Arg Asp Lys Pro Xaa Ala Glu Arg Phe Ile Ala Met Asn Arg Gly 
    210                 215                 220                 


Ile Asn Glu Gly Gly Asp Leu Pro Glu Glu Leu Leu Arg Asn Leu Tyr 
225                 230                 235                 240 


Glu Ser Ile Lys Asn Glu Pro Phe Lys Ile Pro Glu Asp Asp Gly Asn 
                245                 250                 255     


Asp Leu Xaa His Xaa Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu 
            260                 265                 270         


Lys Leu Gly Gly Gly Arg Val Lys Xaa Trp Lys Arg Arg Trp Phe Ile 
        275                 280                 285             


Leu Xaa Asp Asn Cys Leu Tyr Tyr Phe Glu Tyr Xaa Xaa Asp Lys Glu 
    290                 295                 300                 


Pro Arg Gly Ile Ile Pro Leu Glu Asn Leu Ser Ile Arg Glu Val Glu 
305                 310                 315                 320 


Asp Pro Arg Lys Pro Asn Cys Phe Glu Leu Tyr Asn Pro Ser His Lys 
                325                 330                 335     


Gly Gln Val Ile Lys Ala Cys Lys Xaa Glu Ala Asp Gly Arg Val Val 
            340                 345                 350         


Glu Gly Asn His Val Val Tyr Arg Ile Ser Ala Pro Ser Pro Glu Glu 
        355                 360                 365             


Lys Glu Glu Trp Met Lys Ser Ile Lys Ala Ser Ile Ser Arg Asp Pro 
    370                 375                 380                 


Phe Tyr Asp Met Leu Ala Xaa Arg Lys Arg Arg Ile Ala Asn Lys Lys 
385                 390                 395                 400 


<210> 7495
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<400> 7495
Met Asp Leu Cys His Pro Glu Pro Ala Glu Leu Ser Ser Gly Glu Xaa 
1               5                   10                  15      


Glu Glu Leu Gln Arg Ile Lys Trp His Arg Lys Gln Leu Leu Glu Asp 
            20                  25                  30          


Ile Gln Lys Leu Lys Asp Glu Ile Ala Asp Val Phe Ala Gln Ile Asp 
        35                  40                  45              


Cys Phe Glu Ser Ala Glu Glu Ser Arg Met Ala Gln Lys Glu Lys Glu 
    50                  55                  60                  


Leu Cys Ile Gly Arg Lys Lys Phe Asn Met Asp Pro Ala Lys Gly Ile 
65                  70                  75                  80  


Gln Tyr Phe Ile Glu His Lys Leu Leu Xaa Pro Asp Val Gln Asp Ile 
                85                  90                  95      


Ala Arg Phe Leu Tyr Lys Gly Glu Gly Leu Asn Lys Xaa Ala Ile Gly 
            100                 105                 110         


Xaa Tyr Leu Gly Glu 
        115         


<210> 7496
<211> 157
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<400> 7496
Met Asp Leu Cys His Pro Glu Pro Ala Glu Leu Ser Ser Gly Glu Xaa 
1               5                   10                  15      


Glu Glu Leu Gln Arg Ile Lys Trp His Arg Lys Gln Leu Leu Glu Asp 
            20                  25                  30          


Ile Gln Lys Leu Lys Asp Glu Ile Ala Asp Val Phe Ala Gln Ile Asp 
        35                  40                  45              


Cys Phe Glu Ser Ala Glu Glu Ser Arg Met Ala Gln Lys Glu Lys Glu 
    50                  55                  60                  


Leu Cys Ile Gly Arg Lys Lys Phe Asn Met Asp Pro Ala Lys Gly Ile 
65                  70                  75                  80  


Gln Tyr Phe Ile Glu His Lys Leu Leu Xaa Pro Asp Val Gln Asp Ile 
                85                  90                  95      


Ala Arg Phe Leu Tyr Lys Gly Glu Gly Leu Asn Lys Xaa Ala Ile Gly 
            100                 105                 110         


Xaa Tyr Leu Gly Glu Arg Asp Pro Ile Asn Leu Gln Val Leu Gln Ala 
        115                 120                 125             


Phe Val Asp Cys His Glu Phe Ala Asn Leu Asn Leu Val Gln Ala Leu 
    130                 135                 140                 


Arg Phe Arg Glu Gly Ala Ser Asp Leu Gly Phe Gly Gly 
145                 150                 155         


<210> 7497
<211> 394
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (284)..(284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<400> 7497
Met Asp Leu Cys His Pro Glu Pro Ala Glu Leu Ser Ser Gly Glu Xaa 
1               5                   10                  15      


Glu Glu Leu Gln Arg Ile Lys Trp His Arg Lys Gln Leu Leu Glu Asp 
            20                  25                  30          


Ile Gln Lys Leu Lys Asp Glu Ile Ala Asp Val Phe Ala Gln Ile Asp 
        35                  40                  45              


Cys Phe Glu Ser Ala Glu Glu Ser Arg Met Ala Gln Lys Glu Lys Glu 
    50                  55                  60                  


Leu Cys Ile Gly Arg Lys Lys Phe Asn Met Asp Pro Ala Lys Gly Ile 
65                  70                  75                  80  


Gln Tyr Phe Ile Glu His Lys Leu Leu Xaa Pro Asp Val Gln Asp Ile 
                85                  90                  95      


Ala Arg Phe Leu Tyr Lys Gly Glu Gly Leu Asn Lys Xaa Ala Ile Gly 
            100                 105                 110         


Xaa Tyr Leu Gly Glu Arg Asp Pro Ile Asn Leu Gln Val Leu Gln Ala 
        115                 120                 125             


Phe Val Asp Cys His Glu Phe Ala Asn Leu Asn Leu Val Gln Ala Leu 
    130                 135                 140                 


Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly Glu Ala Gln Lys Ile 
145                 150                 155                 160 


Asp Arg Met Met Glu Ala Phe Ala Xaa Arg Tyr Cys Leu Cys Asn Pro 
                165                 170                 175     


Gly Val Phe Gln Ser Xaa Asp Xaa Cys Tyr Val Leu Ser Phe Ser Ile 
            180                 185                 190         


Ile Met Leu Asn Xaa Ser Leu His Asn Pro Asn Val Arg Asp Arg Pro 
        195                 200                 205             


Pro Phe Glu Arg Phe Val Ser Met Asn Arg Gly Ile Asn Asn Gly Ser 
    210                 215                 220                 


Asp Leu Pro Glu Asp Gln Leu Arg Asn Leu Phe Asp Ser Ile Lys Ser 
225                 230                 235                 240 


Glu Pro Phe Ser Ile Pro Glu Asp Asp Gly Asn Asp Leu Xaa His Xaa 
                245                 250                 255     


Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu Lys Leu Gly Gly Arg 
            260                 265                 270         


Val Lys Xaa Trp Lys Arg Arg Trp Phe Ile Leu Xaa Asp Asn Cys Leu 
        275                 280                 285             


Tyr Tyr Phe Glu Phe Xaa Xaa Asp Lys Glu Pro Arg Gly Ile Ile Pro 
    290                 295                 300                 


Leu Glu Asn Leu Ser Val Gln Lys Val Asp Asp Pro Lys Lys Pro Phe 
305                 310                 315                 320 


Cys Leu Glu Leu Tyr Asn Pro Ser Cys Arg Gly Gln Lys Ile Lys Ala 
                325                 330                 335     


Cys Lys Xaa Asp Gly Asp Gly Arg Val Val Glu Gly Lys His Glu Ser 
            340                 345                 350         


Tyr Arg Ile Ser Ala Xaa Ser Ala Glu Glu Arg Asp Gln Trp Ile Glu 
        355                 360                 365             


Ser Ile Arg Ala Ser Ile Xaa Arg Val Pro Phe Tyr Asp Leu Val Ser 
    370                 375                 380                 


Xaa Arg Lys Lys Lys Ile Ala Ser Lys Gln 
385                 390                 


<210> 7498
<211> 154
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<400> 7498
Met Asp Leu Cys His Pro Glu Pro Ala Glu Leu Ser Ser Gly Glu Xaa 
1               5                   10                  15      


Glu Glu Leu Gln Arg Ile Lys Trp His Arg Lys Gln Leu Leu Glu Asp 
            20                  25                  30          


Ile Gln Lys Leu Lys Asp Glu Ile Ala Asp Val Phe Ala Gln Ile Asp 
        35                  40                  45              


Cys Phe Glu Ser Ala Glu Glu Ser Arg Met Ala Gln Lys Glu Lys Glu 
    50                  55                  60                  


Leu Cys Ile Gly Arg Lys Lys Phe Asn Met Asp Pro Ala Lys Gly Ile 
65                  70                  75                  80  


Gln Tyr Phe Ile Glu His Lys Leu Leu Xaa Pro Asp Val Gln Asp Ile 
                85                  90                  95      


Ala Arg Phe Leu Tyr Lys Gly Glu Gly Leu Asn Lys Xaa Ala Ile Gly 
            100                 105                 110         


Xaa Tyr Leu Gly Glu Arg Asp Pro Ile Asn Leu Gln Val Leu Gln Ala 
        115                 120                 125             


Phe Val Asp Cys His Glu Phe Ala Asn Leu Asn Leu Val Gln Ala Leu 
    130                 135                 140                 


Arg Val Val Lys Xaa Lys Trp Glu Ser Val 
145                 150                 


<210> 7499
<211> 147
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<400> 7499
Xaa Xaa His Xaa Ser Gly Ser Leu Ser Ser Arg Asp Ser Gln Ala Gly 
1               5                   10                  15      


Asp Ser Ala Ser Arg Ala Gly Gly Arg Val Lys Xaa Trp Lys Arg Arg 
            20                  25                  30          


Trp Phe Ile Leu Xaa Asp Asn Cys Leu Tyr Tyr Phe Glu Phe Xaa Xaa 
        35                  40                  45              


Asp Lys Glu Pro Arg Gly Ile Ile Pro Leu Glu Asn Leu Ser Val Gln 
    50                  55                  60                  


Lys Val Asp Asp Pro Lys Lys Pro Phe Cys Leu Glu Leu Tyr Asn Pro 
65                  70                  75                  80  


Ser Cys Arg Gly Gln Lys Ile Lys Ala Cys Lys Xaa Asp Gly Asp Gly 
                85                  90                  95      


Arg Val Val Glu Gly Lys His Glu Ser Tyr Arg Ile Ser Ala Xaa Ser 
            100                 105                 110         


Ala Glu Glu Arg Asp Gln Trp Ile Glu Ser Ile Arg Ala Ser Ile Xaa 
        115                 120                 125             


Arg Val Pro Phe Tyr Asp Leu Val Ser Xaa Arg Lys Lys Lys Ile Ala 
    130                 135                 140                 


Ser Lys Gln 
145         


<210> 7500
<211> 136
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(129)
<223> Selenocysteine

<400> 7500
Met Arg Xaa Pro Gly Pro Leu Pro Val Leu Leu Leu Leu Leu Ala Gly 
1               5                   10                  15      


Ala Pro Ala Ala Arg Pro Xaa Pro Pro Xaa Cys Tyr Ser Arg Met Arg 
            20                  25                  30          


Ala Leu Ser Gln Glu Ile Xaa Arg Asp Phe Asn Leu Leu Gln Val Ser 
        35                  40                  45              


Glu Pro Ser Glu Pro Cys Val Arg Tyr Leu Pro Arg Leu Tyr Leu Asp 
    50                  55                  60                  


Ile His Asn Tyr Cys Val Leu Asp Lys Leu Arg Asp Phe Val Ala Ser 
65                  70                  75                  80  


Pro Pro Cys Trp Lys Val Ala Gln Val Asp Ser Leu Lys Asp Lys Ala 
                85                  90                  95      


Arg Lys Leu Tyr Xaa Ile Met Asn Ser Phe Cys Arg Arg Asp Leu Val 
            100                 105                 110         


Phe Leu Leu Asp Asp Cys Asn Ala Leu Glu Tyr Pro Ile Pro Val Xaa 
        115                 120                 125             


Xaa Val Leu Pro Asp Arg Gln Arg 
    130                 135     


<210> 7501
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(69)
<223> Selenocysteine

<400> 7501
Xaa Pro Gly Pro Leu Pro Val Leu Leu Leu Leu Leu Ala Gly Ala Pro 
1               5                   10                  15      


Ala Ala Arg Pro Xaa Pro Pro Xaa Cys Tyr Ser Arg Met Arg Ala Leu 
            20                  25                  30          


Ser Gln Glu Ile Xaa Arg Asp Phe Asn Leu Leu Gln Val Ser Glu Pro 
        35                  40                  45              


Ser Asp Leu Val Phe Leu Leu Asp Asp Cys Asn Ala Leu Glu Tyr Pro 
    50                  55                  60                  


Ile Pro Val Xaa Xaa Val Leu Pro Asp Arg Gln Arg 
65                  70                  75      


<210> 7502
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(85)
<223> Selenocysteine

<400> 7502
Xaa Xaa Pro Gly Pro Leu Pro Val Leu Leu Leu Leu Leu Ala Gly Ala 
1               5                   10                  15      


Pro Ala Ala Arg Pro Xaa Pro Pro Xaa Cys Tyr Ser Arg Met Arg Ala 
            20                  25                  30          


Leu Ser Gln Glu Ile Xaa Arg Asp Phe Asn Leu Leu Gln Val Ser Glu 
        35                  40                  45              


Pro Ser Glu Pro Cys Val Arg Tyr Leu Pro Arg Leu Tyr Leu Asp Ile 
    50                  55                  60                  


His Asp Leu Val Phe Leu Leu Asp Asp Cys Asn Ala Leu Glu Tyr Pro 
65                  70                  75                  80  


Ile Pro Val Xaa Xaa Val Leu Pro Asp Arg Gln Arg 
                85                  90          


<210> 7503
<211> 1068
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (836)..(836)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (852)..(852)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (923)..(923)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1055)..(1055)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1064)..(1064)
<223> Selenocysteine

<400> 7503
Met Ala Pro Arg Lys Arg Gly Gly Arg Gly Ile Ser Phe Ile Phe Cys 
1               5                   10                  15      


Cys Phe Arg Asn Asn Asp His Pro Glu Ile Xaa Tyr Arg Leu Arg Asn 
            20                  25                  30          


Asp Ser Asn Phe Ala Leu Gln Xaa Met Glu Pro Ala Leu Pro Met Pro 
        35                  40                  45              


Pro Val Glu Glu Leu Asp Val Met Phe Ser Glu Leu Val Asp Glu Leu 
    50                  55                  60                  


Asp Leu Xaa Asp Lys His Arg Glu Ala Met Phe Ala Leu Pro Ala Glu 
65                  70                  75                  80  


Lys Lys Trp Gln Ile Tyr Cys Ser Lys Lys Lys Asp Gln Glu Glu Asn 
                85                  90                  95      


Lys Gly Ala Xaa Ser Trp Pro Glu Phe Tyr Ile Asp Gln Leu Asn Ser 
            100                 105                 110         


Met Ala Ala Arg Lys Ser Leu Leu Ala Leu Glu Lys Glu Glu Glu Glu 
        115                 120                 125             


Glu Arg Ser Lys Xaa Ile Glu Ser Leu Lys Xaa Ala Leu Arg Xaa Lys 
    130                 135                 140                 


Pro Met Arg Phe Val Xaa Arg Phe Ile Asp Leu Asp Gly Leu Ser Cys 
145                 150                 155                 160 


Ile Leu Asn Phe Leu Lys Xaa Met Asp Tyr Glu Xaa Ser Glu Ser Arg 
                165                 170                 175     


Ile His Xaa Ser Leu Ile Gly Cys Ile Lys Ala Leu Met Asn Asn Ser 
            180                 185                 190         


Gln Gly Arg Ala His Val Leu Ala His Ser Glu Ser Ile Asn Val Ile 
        195                 200                 205             


Ala Gln Ser Leu Ser Xaa Glu Asn Ile Lys Xaa Lys Val Ala Val Leu 
    210                 215                 220                 


Glu Ile Leu Gly Ala Val Cys Leu Val Pro Gly Gly His Lys Lys Val 
225                 230                 235                 240 


Leu Gln Ala Met Leu His Tyr Gln Lys Tyr Ala Ser Glu Arg Xaa Arg 
                245                 250                 255     


Phe Gln Xaa Leu Ile Asn Asp Leu Asp Lys Ser Xaa Gly Arg Tyr Arg 
            260                 265                 270         


Asp Glu Val Ser Leu Lys Xaa Ala Ile Met Ser Phe Ile Asn Ala Val 
        275                 280                 285             


Leu Ser Gln Gly Ala Gly Val Glu Ser Leu Asp Phe Arg Leu His Leu 
    290                 295                 300                 


Arg Tyr Glu Phe Leu Met Leu Gly Ile Gln Pro Val Ile Asp Lys Leu 
305                 310                 315                 320 


Arg Glu His Glu Asn Ser Xaa Leu Asp Arg His Leu Asp Phe Phe Glu 
                325                 330                 335     


Met Leu Arg Asn Glu Asp Glu Leu Glu Phe Ala Lys Arg Phe Glu Leu 
            340                 345                 350         


Val His Ile Asp Xaa Lys Ser Ala Xaa Gln Met Phe Glu Leu Xaa Arg 
        355                 360                 365             


Lys Arg Leu Xaa His Ser Glu Ala Tyr Pro His Phe Met Ser Ile Leu 
    370                 375                 380                 


His His Cys Leu Gln Met Pro Tyr Lys Arg Ser Gly Asn Xaa Val Gln 
385                 390                 395                 400 


Tyr Trp Leu Leu Leu Asp Arg Ile Ile Gln Gln Ile Val Ile Gln Asn 
                405                 410                 415     


Asp Lys Gly Gln Asp Pro Asp Ser Xaa Pro Leu Glu Asn Phe Asn Ile 
            420                 425                 430         


Lys Asn Val Val Arg Met Leu Val Asn Glu Asn Glu Val Lys Gln Trp 
        435                 440                 445             


Lys Glu Gln Ala Glu Lys Met Arg Lys Glu His Asn Glu Leu Gln Gln 
    450                 455                 460                 


Lys Leu Glu Lys Lys Glu Arg Glu Cys Asp Ala Lys Xaa Gln Glu Lys 
465                 470                 475                 480 


Glu Glu Met Met Gln Xaa Leu Asn Lys Met Lys Glu Lys Leu Glu Lys 
                485                 490                 495     


Glu Xaa Xaa Glu His Lys Gln Val Lys Gln Gln Val Ala Asp Leu Xaa 
            500                 505                 510         


Ala Gln Leu His Glu Leu Ser Arg Arg Ala Val Cys Ala Ser Ile Pro 
        515                 520                 525             


Gly Gly Pro Ser Pro Gly Ala Pro Gly Gly Pro Phe Pro Ser Ser Val 
    530                 535                 540                 


Pro Gly Ser Leu Leu Pro Pro Pro Pro Pro Pro Pro Leu Pro Gly Gly 
545                 550                 555                 560 


Met Leu Pro Pro Pro Pro Pro Pro Leu Pro Pro Gly Gly Pro Pro Pro 
                565                 570                 575     


Pro Pro Gly Pro Pro Pro Leu Gly Ala Ile Met Pro Pro Pro Gly Ala 
            580                 585                 590         


Pro Met Gly Leu Ala Leu Lys Lys Lys Ser Ile Pro Gln Pro Xaa Asn 
        595                 600                 605             


Ala Leu Lys Ser Phe Asn Trp Ser Lys Leu Pro Glu Asn Lys Leu Glu 
    610                 615                 620                 


Gly Xaa Val Trp Xaa Glu Ile Asp Asp Xaa Lys Val Phe Lys Ile Leu 
625                 630                 635                 640 


Asp Leu Glu Asp Leu Glu Arg Xaa Phe Ser Ala Tyr Gln Arg Gln Gln 
                645                 650                 655     


Lys Glu Ala Asp Ala Ile Asp Asp Xaa Leu Ser Ser Lys Leu Lys Val 
            660                 665                 670         


Lys Glu Leu Ser Val Ile Asp Gly Arg Arg Ala Gln Asn Cys Asn Ile 
        675                 680                 685             


Leu Leu Ser Arg Leu Lys Leu Ser Asn Asp Glu Ile Lys Arg Ala Ile 
    690                 695                 700                 


Leu Xaa Met Asp Glu Gln Glu Asp Leu Pro Lys Asp Met Leu Glu Gln 
705                 710                 715                 720 


Leu Leu Lys Phe Val Pro Glu Lys Ser Asp Ile Asp Leu Leu Glu Glu 
                725                 730                 735     


His Lys His Glu Leu Asp Arg Met Ala Lys Ala Asp Arg Phe Leu Phe 
            740                 745                 750         


Glu Met Ser Arg Ile Asn His Tyr Gln Gln Arg Leu Gln Ser Leu Tyr 
        755                 760                 765             


Phe Lys Lys Lys Phe Ala Glu Arg Val Ala Glu Val Lys Pro Lys Val 
    770                 775                 780                 


Glu Ala Ile Arg Ser Gly Ser Glu Glu Val Phe Arg Ser Gly Ala Leu 
785                 790                 795                 800 


Lys Gln Leu Leu Glu Val Val Leu Ala Phe Gly Asn Tyr Met Asn Lys 
                805                 810                 815     


Gly Gln Arg Gly Asn Ala Tyr Gly Phe Lys Ile Ser Ser Leu Asn Lys 
            820                 825                 830         


Ile Ala Asp Xaa Lys Ser Ser Ile Asp Lys Asn Ile Xaa Leu Leu His 
        835                 840                 845             


Tyr Leu Ile Xaa Ile Val Glu Asn Lys Tyr Pro Ser Val Leu Asn Leu 
    850                 855                 860                 


Asn Glu Glu Leu Arg Asp Ile Pro Gln Ala Ala Lys Val Asn Met Xaa 
865                 870                 875                 880 


Glu Leu Asp Lys Glu Ile Ser Xaa Leu Arg Ser Gly Leu Lys Ala Val 
                885                 890                 895     


Glu Xaa Glu Leu Glu Tyr Gln Lys Ser Gln Pro Pro Gln Pro Gly Asp 
            900                 905                 910         


Lys Phe Val Ser Val Val Ser Gln Phe Ile Xaa Val Ala Ser Phe Ser 
        915                 920                 925             


Phe Ser Asp Val Glu Asp Leu Leu Ala Glu Ala Lys Asp Leu Phe Xaa 
    930                 935                 940                 


Lys Ala Val Lys His Phe Gly Glu Glu Ala Gly Lys Ile Gln Pro Asp 
945                 950                 955                 960 


Glu Phe Phe Gly Ile Phe Asp Gln Phe Leu Gln Ala Val Ser Glu Ala 
                965                 970                 975     


Lys Gln Glu Asn Glu Asn Met Arg Lys Lys Lys Glu Glu Glu Glu Arg 
            980                 985                 990         


Arg Ala Arg Met Glu Ala Gln Leu  Lys Glu Gln Arg Glu  Arg Glu Arg 
        995                 1000                 1005             


Lys Met  Arg Lys Ala Lys Glu  Asn Ser Glu Glu Ser  Gly Glu Phe 
    1010                 1015                 1020             


Asp Asp  Leu Val Ser Ala Leu  Arg Ser Gly Glu Val  Phe Asp Lys 
    1025                 1030                 1035             


Asp Leu  Ser Lys Leu Lys Arg  Asn Arg Lys Arg Ile  Xaa Asn Gln 
    1040                 1045                 1050             


Met Xaa  Asp Ser Ser Arg Glu  Arg Pro Ile Xaa Lys  Leu Asn Phe 
    1055                 1060                 1065             


<210> 7504
<211> 1078
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(499)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (629)..(629)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (862)..(862)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (954)..(954)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1074)..(1074)
<223> Selenocysteine

<400> 7504
Met Ala Pro Arg Lys Arg Gly Gly Arg Gly Ile Ser Phe Ile Phe Cys 
1               5                   10                  15      


Cys Phe Arg Asn Asn Asp His Pro Glu Ile Xaa Tyr Arg Leu Arg Asn 
            20                  25                  30          


Asp Ser Asn Phe Ala Leu Gln Xaa Met Glu Pro Ala Leu Pro Met Pro 
        35                  40                  45              


Pro Val Glu Glu Leu Asp Val Met Phe Ser Glu Leu Val Asp Glu Leu 
    50                  55                  60                  


Asp Leu Xaa Asp Lys His Arg Glu Ala Met Phe Ala Leu Pro Ala Glu 
65                  70                  75                  80  


Lys Lys Trp Gln Ile Tyr Cys Ser Lys Lys Lys Asp Gln Glu Glu Asn 
                85                  90                  95      


Lys Gly Ala Xaa Ser Trp Pro Glu Phe Tyr Ile Asp Gln Leu Asn Ser 
            100                 105                 110         


Met Ala Ala Arg Lys Ser Leu Leu Ala Leu Glu Lys Glu Glu Glu Glu 
        115                 120                 125             


Glu Arg Ser Lys Xaa Ile Glu Ser Leu Lys Xaa Ala Leu Arg Xaa Lys 
    130                 135                 140                 


Pro Met Arg Phe Val Xaa Arg Phe Ile Asp Leu Asp Gly Leu Ser Cys 
145                 150                 155                 160 


Ile Leu Asn Phe Leu Lys Xaa Met Asp Tyr Glu Xaa Ser Glu Ser Arg 
                165                 170                 175     


Ile His Xaa Ser Leu Ile Gly Cys Ile Lys Ala Leu Met Asn Asn Ser 
            180                 185                 190         


Gln Gly Arg Ala His Val Leu Ala His Ser Glu Ser Ile Asn Val Ile 
        195                 200                 205             


Ala Gln Ser Leu Ser Xaa Glu Asn Ile Lys Xaa Lys Val Ala Val Leu 
    210                 215                 220                 


Glu Ile Leu Gly Ala Val Cys Leu Val Pro Gly Gly His Lys Lys Val 
225                 230                 235                 240 


Leu Gln Ala Met Leu His Tyr Gln Lys Tyr Ala Ser Glu Arg Xaa Arg 
                245                 250                 255     


Phe Gln Xaa Leu Ile Asn Asp Leu Asp Lys Ser Xaa Gly Arg Tyr Arg 
            260                 265                 270         


Asp Glu Val Ser Leu Lys Xaa Ala Ile Met Ser Phe Ile Asn Ala Val 
        275                 280                 285             


Leu Ser Gln Gly Ala Gly Val Glu Ser Leu Asp Phe Arg Leu His Leu 
    290                 295                 300                 


Arg Tyr Glu Phe Leu Met Leu Gly Ile Gln Pro Val Ile Asp Lys Leu 
305                 310                 315                 320 


Arg Glu His Glu Asn Ser Xaa Leu Asp Arg His Leu Asp Phe Phe Glu 
                325                 330                 335     


Met Leu Arg Asn Glu Asp Glu Leu Glu Phe Ala Lys Arg Phe Glu Leu 
            340                 345                 350         


Val His Ile Asp Xaa Lys Ser Ala Xaa Gln Met Phe Glu Leu Xaa Arg 
        355                 360                 365             


Lys Arg Leu Xaa His Ser Glu Ala Tyr Pro His Phe Met Ser Ile Leu 
    370                 375                 380                 


His His Cys Leu Gln Met Pro Tyr Lys Arg Ser Gly Asn Xaa Val Gln 
385                 390                 395                 400 


Tyr Trp Leu Leu Leu Asp Arg Ile Ile Gln Gln Ile Val Ile Gln Asn 
                405                 410                 415     


Asp Lys Gly Gln Asp Pro Asp Ser Xaa Pro Leu Glu Asn Phe Asn Ile 
            420                 425                 430         


Lys Asn Val Val Arg Met Leu Val Asn Glu Asn Glu Val Lys Gln Trp 
        435                 440                 445             


Lys Glu Gln Ala Glu Lys Met Arg Lys Glu His Asn Glu Leu Gln Gln 
    450                 455                 460                 


Lys Leu Glu Lys Lys Glu Arg Glu Cys Asp Ala Lys Xaa Gln Glu Lys 
465                 470                 475                 480 


Glu Glu Met Met Gln Xaa Leu Asn Lys Met Lys Glu Lys Leu Glu Lys 
                485                 490                 495     


Glu Xaa Xaa Glu His Lys Gln Val Lys Gln Gln Val Ala Asp Leu Xaa 
            500                 505                 510         


Ala Gln Leu His Glu Leu Ser Arg Arg Ala Val Cys Ala Ser Ile Pro 
        515                 520                 525             


Gly Gly Pro Ser Pro Gly Ala Pro Gly Gly Pro Phe Pro Ser Ser Val 
    530                 535                 540                 


Pro Gly Ser Leu Leu Pro Pro Pro Pro Pro Pro Pro Leu Pro Gly Gly 
545                 550                 555                 560 


Met Leu Pro Pro Pro Pro Pro Pro Leu Pro Pro Gly Gly Pro Pro Pro 
                565                 570                 575     


Pro Pro Gly Pro Pro Pro Leu Gly Ala Ile Met Pro Pro Pro Gly Ala 
            580                 585                 590         


Pro Met Gly Leu Ala Leu Lys Lys Lys Ser Ile Pro Gln Pro Xaa Asn 
        595                 600                 605             


Ala Leu Lys Ser Phe Asn Trp Ser Lys Leu Pro Glu Asn Lys Leu Glu 
    610                 615                 620                 


Gly Xaa Val Trp Xaa Glu Ile Asp Asp Xaa Lys Val Phe Lys Ile Leu 
625                 630                 635                 640 


Asp Leu Glu Asp Leu Glu Arg Xaa Phe Ser Ala Tyr Gln Arg Gln Gln 
                645                 650                 655     


Asp Phe Phe Val Asn Ser Asn Ser Lys Gln Lys Glu Ala Asp Ala Ile 
            660                 665                 670         


Asp Asp Xaa Leu Ser Ser Lys Leu Lys Val Lys Glu Leu Ser Val Ile 
        675                 680                 685             


Asp Gly Arg Arg Ala Gln Asn Cys Asn Ile Leu Leu Ser Arg Leu Lys 
    690                 695                 700                 


Leu Ser Asn Asp Glu Ile Lys Arg Ala Ile Leu Xaa Met Asp Glu Gln 
705                 710                 715                 720 


Glu Asp Leu Pro Lys Asp Met Leu Glu Gln Leu Leu Lys Phe Val Pro 
                725                 730                 735     


Glu Lys Ser Asp Ile Asp Leu Leu Glu Glu His Lys His Glu Leu Asp 
            740                 745                 750         


Arg Met Ala Lys Ala Asp Arg Phe Leu Phe Glu Met Ser Arg Ile Asn 
        755                 760                 765             


His Tyr Gln Gln Arg Leu Gln Ser Leu Tyr Phe Lys Lys Lys Phe Ala 
    770                 775                 780                 


Glu Arg Val Ala Glu Val Lys Pro Lys Val Glu Ala Ile Arg Ser Gly 
785                 790                 795                 800 


Ser Glu Glu Val Phe Arg Ser Gly Ala Leu Lys Gln Leu Leu Glu Val 
                805                 810                 815     


Val Leu Ala Phe Gly Asn Tyr Met Asn Lys Gly Gln Arg Gly Asn Ala 
            820                 825                 830         


Tyr Gly Phe Lys Ile Ser Ser Leu Asn Lys Ile Ala Asp Xaa Lys Ser 
        835                 840                 845             


Ser Ile Asp Lys Asn Ile Xaa Leu Leu His Tyr Leu Ile Xaa Ile Val 
    850                 855                 860                 


Glu Asn Lys Tyr Pro Ser Val Leu Asn Leu Asn Glu Glu Leu Arg Asp 
865                 870                 875                 880 


Ile Pro Gln Ala Ala Lys Val Asn Met Xaa Glu Leu Asp Lys Glu Ile 
                885                 890                 895     


Ser Xaa Leu Arg Ser Gly Leu Lys Ala Val Glu Xaa Glu Leu Glu Tyr 
            900                 905                 910         


Gln Lys Ser Gln Pro Pro Gln Pro Gly Asp Lys Phe Val Ser Val Val 
        915                 920                 925             


Ser Gln Phe Ile Xaa Val Ala Ser Phe Ser Phe Ser Asp Val Glu Asp 
    930                 935                 940                 


Leu Leu Ala Glu Ala Lys Asp Leu Phe Xaa Lys Ala Val Lys His Phe 
945                 950                 955                 960 


Gly Glu Glu Ala Gly Lys Ile Gln Pro Asp Glu Phe Phe Gly Ile Phe 
                965                 970                 975     


Asp Gln Phe Leu Gln Ala Val Ser Glu Ala Lys Gln Glu Asn Glu Asn 
            980                 985                 990         


Met Arg Lys Lys Lys Glu Glu Glu  Glu Arg Arg Ala Arg  Met Glu Ala 
        995                 1000                 1005             


Gln Leu  Lys Glu Gln Arg Glu  Arg Glu Arg Lys Met  Arg Lys Ala 
    1010                 1015                 1020             


Lys Glu  Asn Ser Glu Glu Ser  Gly Glu Phe Asp Asp  Leu Val Ser 
    1025                 1030                 1035             


Ala Leu  Arg Ser Gly Glu Val  Phe Asp Lys Asp Leu  Ser Lys Leu 
    1040                 1045                 1050             


Lys Arg  Asn Arg Lys Arg Ile  Xaa Asn Gln Met Xaa  Asp Ser Ser 
    1055                 1060                 1065             


Arg Glu  Arg Pro Ile Xaa Lys  Leu Asn Phe 
    1070                 1075             


<210> 7505
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<400> 7505
Met Ala Pro Arg Lys Arg Gly Gly Arg Gly Ile Ser Phe Ile Phe Cys 
1               5                   10                  15      


Cys Phe Arg Asn Asn Asp His Pro Glu Ile Xaa Tyr Arg Leu Arg Asn 
            20                  25                  30          


Asp Ser Asn Phe Ala Leu Gln Xaa Met Glu Pro Ala Leu Pro Met Pro 
        35                  40                  45              


Pro Val Glu Glu Leu Asp Val Met Phe Ser Glu Leu Val Asp Glu Leu 
    50                  55                  60                  


Asp Leu Xaa Asp Lys His Arg Glu Ala Met Phe Ala Leu Pro Ala Glu 
65                  70                  75                  80  


Lys Lys Trp Gln Ile Tyr Cys Ser Lys Lys Lys Val Arg Phe Ser Leu 
                85                  90                  95      


<210> 7506
<211> 213
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<400> 7506
Met Ser Xaa Glu Xaa Glu Leu Gln Val Ala Val Lys Xaa Ser Ala Lys 
1               5                   10                  15      


Lys Asp Ser Arg Lys Lys Gly Gln Asp Arg Ser Glu Ala Xaa Leu Ile 
            20                  25                  30          


Lys Arg Phe Lys Gly Glu Gly Val Arg Tyr Lys Ala Lys Leu Ile Gly 
        35                  40                  45              


Ile Asp Glu Val Ser Ala Ala Arg Gly Asp Lys Leu Cys Gln Asp Ser 
    50                  55                  60                  


Met Met Lys Leu Lys Gly Val Val Ala Gly Ala Arg Ser Lys Gly Glu 
65                  70                  75                  80  


His Lys Gln Lys Ile Phe Leu Xaa Ile Ser Phe Gly Gly Ile Lys Ile 
                85                  90                  95      


Phe Asp Glu Lys Xaa Gly Ala Leu Gln His His His Ala Val His Glu 
            100                 105                 110         


Ile Ser Tyr Ile Ala Lys Asp Ile Xaa Asp His Arg Ala Phe Gly Tyr 
        115                 120                 125             


Val Cys Gly Lys Glu Gly Asn His Arg Phe Val Ala Ile Lys Xaa Ala 
    130                 135                 140                 


Gln Ala Ala Glu Pro Val Ile Leu Asp Leu Arg Asp Leu Phe Gln Leu 
145                 150                 155                 160 


Ile Tyr Glu Leu Lys Gln Arg Glu Glu Leu Glu Lys Lys Ala Gln Lys 
                165                 170                 175     


Asp Lys Gln Cys Glu Gln Ala Val Tyr Gln Xaa Ile Leu Glu Glu Asp 
            180                 185                 190         


Val Glu Asp Pro Val Tyr Gln Val Ile Ser Glu Xaa Ser Arg Gly Phe 
        195                 200                 205             


Arg Phe Lys Ser Asp 
    210             


<210> 7507
<211> 555
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (385)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (475)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (504)..(505)
<223> Selenocysteine

<400> 7507
Met Ser Xaa Glu Xaa Glu Leu Gln Val Ala Val Lys Xaa Ser Ala Lys 
1               5                   10                  15      


Lys Asp Ser Arg Lys Lys Gly Gln Asp Arg Ser Glu Ala Xaa Leu Ile 
            20                  25                  30          


Lys Arg Phe Lys Gly Glu Gly Val Arg Tyr Lys Ala Lys Leu Ile Gly 
        35                  40                  45              


Ile Asp Glu Val Ser Ala Ala Arg Gly Asp Lys Leu Cys Gln Asp Ser 
    50                  55                  60                  


Met Met Lys Leu Lys Gly Val Val Ala Gly Ala Arg Ser Lys Gly Glu 
65                  70                  75                  80  


His Lys Gln Lys Ile Phe Leu Xaa Ile Ser Phe Gly Gly Ile Lys Ile 
                85                  90                  95      


Phe Asp Glu Lys Xaa Gly Ala Leu Gln His His His Ala Val His Glu 
            100                 105                 110         


Ile Ser Tyr Ile Ala Lys Asp Ile Xaa Asp His Arg Ala Phe Gly Tyr 
        115                 120                 125             


Val Cys Gly Lys Glu Gly Asn His Arg Phe Val Ala Ile Lys Xaa Ala 
    130                 135                 140                 


Gln Ala Ala Glu Pro Val Ile Leu Asp Leu Arg Asp Leu Phe Gln Leu 
145                 150                 155                 160 


Ile Tyr Glu Leu Lys Gln Arg Glu Glu Leu Glu Lys Lys Ala Gln Lys 
                165                 170                 175     


Asp Lys Gln Cys Glu Gln Ala Val Tyr Gln Xaa Ile Leu Glu Glu Asp 
            180                 185                 190         


Val Glu Asp Pro Val Tyr Gln Tyr Ile Val Phe Glu Ala Gly His Glu 
        195                 200                 205             


Pro Ile Arg Asp Pro Glu Xaa Glu Glu Asn Ile Tyr Gln Val Pro Xaa 
    210                 215                 220                 


Ser Gln Lys Lys Glu Gly Val Tyr Asp Val Pro Lys Ser Gln Pro Val 
225                 230                 235                 240 


Ser Ala Val Xaa Gln Leu Glu Leu Phe Gly Asp Met Ser Xaa Pro Pro 
                245                 250                 255     


Asp Ile Xaa Ser Pro Pro Xaa Pro Ala Xaa Pro Gly Asp Ala Phe Ile 
            260                 265                 270         


Pro Ser Ser Ser Gln Xaa Leu Pro Ala Ser Ala Asp Val Phe Ser Ser 
        275                 280                 285             


Val Pro Phe Gly Xaa Ala Ala Val Pro Ser Gly Tyr Val Ala Met Gly 
    290                 295                 300                 


Ala Val Leu Pro Ser Phe Trp Gly Gln Gln Pro Leu Val Gln Gln Gln 
305                 310                 315                 320 


Met Val Met Gly Ala Gln Pro Pro Val Ala Gln Val Met Pro Gly Ala 
                325                 330                 335     


Gln Pro Ile Ala Trp Gly Gln Pro Gly Leu Phe Pro Ala Xaa Gln Gln 
            340                 345                 350         


Pro Trp Pro Xaa Val Ala Gly Gln Phe Pro Pro Ala Ala Phe Met Pro 
        355                 360                 365             


Xaa Gln Xaa Val Met Pro Leu Pro Ala Ala Met Phe Gln Gly Pro Leu 
    370                 375                 380                 


Xaa Pro Leu Ala Xaa Val Pro Gly Xaa Ser Asp Ser Xaa Arg Ser Ser 
385                 390                 395                 400 


Pro Gln Xaa Asp Lys Pro Arg Gln Lys Met Gly Lys Glu Xaa Phe Lys 
                405                 410                 415     


Asp Phe Gln Met Ala Gln Pro Pro Pro Val Pro Ser Arg Lys Pro Asp 
            420                 425                 430         


Gln Pro Ser Leu Xaa Cys Xaa Ser Glu Ala Phe Ser Ser Tyr Phe Asn 
        435                 440                 445             


Lys Val Gly Val Ala Gln Asp Xaa Asp Asp Cys Asp Asp Phe Asp Ile 
    450                 455                 460                 


Ser Gln Leu Asn Leu Xaa Pro Val Xaa Ser Xaa Xaa Pro Ser Xaa Asn 
465                 470                 475                 480 


Ser Pro Pro Xaa Pro Ala Pro Arg Gln Ser Ser Pro Ser Lys Ser Ser 
                485                 490                 495     


Ala Ser His Ala Ser Asp Pro Xaa Xaa Asp Asp Ile Phe Glu Glu Gly 
            500                 505                 510         


Phe Glu Ser Pro Ser Lys Ser Glu Glu Gln Glu Ala Pro Asp Gly Ser 
        515                 520                 525             


Gln Ala Ser Ser Asn Ser Asp Pro Phe Gly Glu Pro Ser Gly Glu Pro 
    530                 535                 540                 


Ser Gly Asp Asn Ile Ser Pro Gln Ala Gly Ser 
545                 550                 555 


<210> 7508
<211> 588
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (472)..(472)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (508)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(538)
<223> Selenocysteine

<400> 7508
Met Ser Xaa Glu Xaa Glu Leu Gln Val Ala Val Lys Xaa Ser Ala Lys 
1               5                   10                  15      


Lys Asp Ser Arg Lys Lys Gly Gln Asp Arg Ser Glu Ala Xaa Leu Ile 
            20                  25                  30          


Lys Arg Phe Lys Gly Glu Gly Val Arg Tyr Lys Ala Lys Leu Ile Gly 
        35                  40                  45              


Ile Asp Glu Val Ser Ala Ala Arg Gly Asp Lys Leu Cys Gln Asp Ser 
    50                  55                  60                  


Met Met Lys Leu Lys Gly Val Val Ala Gly Ala Arg Ser Lys Gly Glu 
65                  70                  75                  80  


His Lys Gln Lys Ile Phe Leu Xaa Ile Ser Phe Gly Gly Ile Lys Ile 
                85                  90                  95      


Phe Asp Glu Lys Xaa Gly Ala Leu Gln His His His Ala Val His Glu 
            100                 105                 110         


Ile Ser Tyr Ile Ala Lys Asp Ile Xaa Asp His Arg Ala Phe Gly Tyr 
        115                 120                 125             


Val Cys Gly Lys Glu Gly Asn His Arg Phe Val Ala Ile Lys Xaa Ala 
    130                 135                 140                 


Gln Ala Ala Glu Pro Val Ile Leu Asp Leu Arg Asp Leu Phe Gln Leu 
145                 150                 155                 160 


Ile Tyr Glu Leu Lys Gln Arg Glu Glu Leu Glu Lys Lys Ala Gln Lys 
                165                 170                 175     


Asp Lys Gln Cys Glu Gln Ala Val Tyr Gln Xaa Ile Leu Glu Glu Asp 
            180                 185                 190         


Val Glu Asp Pro Val Tyr Gln Tyr Ile Val Phe Glu Ala Gly His Glu 
        195                 200                 205             


Pro Ile Arg Asp Pro Glu Xaa Glu Glu Asn Ile Tyr Gln Val Pro Xaa 
    210                 215                 220                 


Ser Gln Lys Lys Glu Gly Val Tyr Asp Val Pro Lys Ser Gln Pro Val 
225                 230                 235                 240 


Ser Asn Gly Tyr Ser Phe Glu Asp Phe Glu Glu Arg Phe Ala Ala Ala 
                245                 250                 255     


Xaa Pro Asn Arg Asn Leu Pro Xaa Asp Phe Asp Glu Ile Phe Glu Ala 
            260                 265                 270         


Xaa Lys Ala Val Xaa Gln Leu Glu Leu Phe Gly Asp Met Ser Xaa Pro 
        275                 280                 285             


Pro Asp Ile Xaa Ser Pro Pro Xaa Pro Ala Xaa Pro Gly Asp Ala Phe 
    290                 295                 300                 


Ile Pro Ser Ser Ser Gln Xaa Leu Pro Ala Ser Ala Asp Val Phe Ser 
305                 310                 315                 320 


Ser Val Pro Phe Gly Xaa Ala Ala Val Pro Ser Gly Tyr Val Ala Met 
                325                 330                 335     


Gly Ala Val Leu Pro Ser Phe Trp Gly Gln Gln Pro Leu Val Gln Gln 
            340                 345                 350         


Gln Met Val Met Gly Ala Gln Pro Pro Val Ala Gln Val Met Pro Gly 
        355                 360                 365             


Ala Gln Pro Ile Ala Trp Gly Gln Pro Gly Leu Phe Pro Ala Xaa Gln 
    370                 375                 380                 


Gln Pro Trp Pro Xaa Val Ala Gly Gln Phe Pro Pro Ala Ala Phe Met 
385                 390                 395                 400 


Pro Xaa Gln Xaa Val Met Pro Leu Pro Ala Ala Met Phe Gln Gly Pro 
                405                 410                 415     


Leu Xaa Pro Leu Ala Xaa Val Pro Gly Xaa Ser Asp Ser Xaa Arg Ser 
            420                 425                 430         


Ser Pro Gln Xaa Asp Lys Pro Arg Gln Lys Met Gly Lys Glu Xaa Phe 
        435                 440                 445             


Lys Asp Phe Gln Met Ala Gln Pro Pro Pro Val Pro Ser Arg Lys Pro 
    450                 455                 460                 


Asp Gln Pro Ser Leu Xaa Cys Xaa Ser Glu Ala Phe Ser Ser Tyr Phe 
465                 470                 475                 480 


Asn Lys Val Gly Val Ala Gln Asp Xaa Asp Asp Cys Asp Asp Phe Asp 
                485                 490                 495     


Ile Ser Gln Leu Asn Leu Xaa Pro Val Xaa Ser Xaa Xaa Pro Ser Xaa 
            500                 505                 510         


Asn Ser Pro Pro Xaa Pro Ala Pro Arg Gln Ser Ser Pro Ser Lys Ser 
        515                 520                 525             


Ser Ala Ser His Ala Ser Asp Pro Xaa Xaa Asp Asp Ile Phe Glu Glu 
    530                 535                 540                 


Gly Phe Glu Ser Pro Ser Lys Ser Glu Glu Gln Glu Ala Pro Asp Gly 
545                 550                 555                 560 


Ser Gln Ala Ser Ser Asn Ser Asp Pro Phe Gly Glu Pro Ser Gly Glu 
                565                 570                 575     


Pro Ser Gly Asp Asn Ile Ser Pro Gln Ala Gly Ser 
            580                 585             


<210> 7509
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<400> 7509
Met Ser Xaa Glu Xaa Glu Leu Gln Val Ala Val Lys Xaa Ser Ala Lys 
1               5                   10                  15      


Lys Asp Ser Arg Lys Lys Gly Gln Asp Arg Ser Glu Ala Xaa Leu Ile 
            20                  25                  30          


Lys Arg Phe Lys Gly Glu Gly Val Arg Tyr Lys Ala Lys Leu Ile Gly 
        35                  40                  45              


Ile Asp Glu Val Ser Ala Ala Arg Gly Asp Lys Leu Cys Gln Asp Ser 
    50                  55                  60                  


Met Met Lys Leu Lys Gly Val Val Ala Gly Ala Arg Ser Lys Gly Glu 
65                  70                  75                  80  


His Lys Gln Lys Ile Phe Leu Xaa Ile Ser Phe Gly Gly Ile Lys Ile 
                85                  90                  95      


Phe Asp Glu Lys Xaa Gly Ala Leu Gln His His His Ala Val His Glu 
            100                 105                 110         


Ile Ser Tyr Ile Ala Lys Asp Ile Xaa Asp His Arg Ala Phe Gly Tyr 
        115                 120                 125             


Val Cys Gly Lys Glu Gly Asn His Arg Phe Val Ala Ile Lys Xaa Ala 
    130                 135                 140                 


Gln Ala Ala Glu Pro Val Ile Leu Asp Leu Arg Asp Leu Phe Gln Leu 
145                 150                 155                 160 


Ile Tyr Glu Leu Lys Gln Arg Glu Glu Leu Glu Lys Lys Ala Gln Lys 
                165                 170                 175     


Asp Lys Gln Cys Glu Gln Ala Val Tyr Gln Val Pro Xaa Ser Gln Lys 
            180                 185                 190         


Lys Glu Gly Val Tyr Asp Val Pro Lys Ser Gln Pro 
        195                 200                 


<210> 7510
<211> 553
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (348)..(348)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (454)..(454)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(474)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(482)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (502)..(503)
<223> Selenocysteine

<400> 7510
Met Ser Xaa Glu Xaa Glu Leu Gln Val Ala Val Lys Xaa Ser Ala Lys 
1               5                   10                  15      


Lys Asp Ser Arg Lys Lys Gly Gln Asp Arg Ser Glu Ala Xaa Leu Ile 
            20                  25                  30          


Lys Arg Phe Lys Gly Glu Gly Val Arg Tyr Lys Ala Lys Leu Ile Gly 
        35                  40                  45              


Ile Asp Glu Val Ser Ala Ala Arg Gly Asp Lys Leu Cys Gln Asp Ser 
    50                  55                  60                  


Met Met Lys Leu Lys Gly Val Val Ala Gly Ala Arg Ser Lys Gly Glu 
65                  70                  75                  80  


His Lys Gln Lys Ile Phe Leu Xaa Ile Ser Phe Gly Gly Ile Lys Ile 
                85                  90                  95      


Phe Asp Glu Lys Xaa Gly Ala Leu Gln His His His Ala Val His Glu 
            100                 105                 110         


Ile Ser Tyr Ile Ala Lys Asp Ile Xaa Asp His Arg Ala Phe Gly Tyr 
        115                 120                 125             


Val Cys Gly Lys Glu Gly Asn His Arg Phe Val Ala Ile Lys Xaa Ala 
    130                 135                 140                 


Gln Ala Ala Glu Pro Val Ile Leu Asp Leu Arg Asp Leu Phe Gln Leu 
145                 150                 155                 160 


Ile Tyr Glu Leu Lys Gln Arg Glu Glu Leu Glu Lys Lys Ala Gln Lys 
                165                 170                 175     


Asp Lys Gln Cys Glu Gln Ala Val Tyr Gln Val Pro Xaa Ser Gln Lys 
            180                 185                 190         


Lys Glu Gly Val Tyr Asp Val Pro Lys Ser Gln Pro Val Ser Asn Gly 
        195                 200                 205             


Tyr Ser Phe Glu Asp Phe Glu Glu Arg Phe Ala Ala Ala Xaa Pro Asn 
    210                 215                 220                 


Arg Asn Leu Pro Xaa Asp Phe Asp Glu Ile Phe Glu Ala Xaa Lys Ala 
225                 230                 235                 240 


Val Xaa Gln Leu Glu Leu Phe Gly Asp Met Ser Xaa Pro Pro Asp Ile 
                245                 250                 255     


Xaa Ser Pro Pro Xaa Pro Ala Xaa Pro Gly Asp Ala Phe Ile Pro Ser 
            260                 265                 270         


Ser Ser Gln Xaa Leu Pro Ala Ser Ala Asp Val Phe Ser Ser Val Pro 
        275                 280                 285             


Phe Gly Xaa Ala Ala Val Pro Ser Gly Tyr Val Ala Met Gly Ala Val 
    290                 295                 300                 


Leu Pro Ser Phe Trp Gly Gln Gln Pro Leu Val Gln Gln Gln Met Val 
305                 310                 315                 320 


Met Gly Ala Gln Pro Pro Val Ala Gln Val Met Pro Gly Ala Gln Pro 
                325                 330                 335     


Ile Ala Trp Gly Gln Pro Gly Leu Phe Pro Ala Xaa Gln Gln Pro Trp 
            340                 345                 350         


Pro Xaa Val Ala Gly Gln Phe Pro Pro Ala Ala Phe Met Pro Xaa Gln 
        355                 360                 365             


Xaa Val Met Pro Leu Pro Ala Ala Met Phe Gln Gly Pro Leu Xaa Pro 
    370                 375                 380                 


Leu Ala Xaa Val Pro Gly Xaa Ser Asp Ser Xaa Arg Ser Ser Pro Gln 
385                 390                 395                 400 


Xaa Asp Lys Pro Arg Gln Lys Met Gly Lys Glu Xaa Phe Lys Asp Phe 
                405                 410                 415     


Gln Met Ala Gln Pro Pro Pro Val Pro Ser Arg Lys Pro Asp Gln Pro 
            420                 425                 430         


Ser Leu Xaa Cys Xaa Ser Glu Ala Phe Ser Ser Tyr Phe Asn Lys Val 
        435                 440                 445             


Gly Val Ala Gln Asp Xaa Asp Asp Cys Asp Asp Phe Asp Ile Ser Gln 
    450                 455                 460                 


Leu Asn Leu Xaa Pro Val Xaa Ser Xaa Xaa Pro Ser Xaa Asn Ser Pro 
465                 470                 475                 480 


Pro Xaa Pro Ala Pro Arg Gln Ser Ser Pro Ser Lys Ser Ser Ala Ser 
                485                 490                 495     


His Ala Ser Asp Pro Xaa Xaa Asp Asp Ile Phe Glu Glu Gly Phe Glu 
            500                 505                 510         


Ser Pro Ser Lys Ser Glu Glu Gln Glu Ala Pro Asp Gly Ser Gln Ala 
        515                 520                 525             


Ser Ser Asn Ser Asp Pro Phe Gly Glu Pro Ser Gly Glu Pro Ser Gly 
    530                 535                 540                 


Asp Asn Ile Ser Pro Gln Ala Gly Ser 
545                 550             


<210> 7511
<211> 239
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<400> 7511
Met Ser Xaa Glu Xaa Glu Leu Gln Val Ala Val Lys Xaa Ser Ala Lys 
1               5                   10                  15      


Lys Asp Ser Arg Lys Lys Gly Gln Asp Arg Ser Glu Ala Xaa Leu Ile 
            20                  25                  30          


Lys Arg Phe Lys Gly Glu Gly Val Arg Tyr Lys Ala Lys Leu Ile Gly 
        35                  40                  45              


Ile Asp Glu Val Ser Ala Ala Arg Gly Asp Lys Leu Cys Gln Asp Ser 
    50                  55                  60                  


Met Met Lys Leu Lys Gly Val Val Ala Gly Ala Arg Ser Lys Gly Glu 
65                  70                  75                  80  


His Lys Gln Lys Ile Phe Leu Xaa Ile Ser Phe Gly Gly Ile Lys Ile 
                85                  90                  95      


Phe Asp Glu Lys Xaa Gly Val Pro Xaa Ser Gln Lys Lys Glu Gly Val 
            100                 105                 110         


Tyr Asp Val Pro Lys Ser Gln Pro Val Ser Asn Gly Tyr Ser Phe Glu 
        115                 120                 125             


Asp Phe Glu Glu Arg Phe Ala Ala Ala Xaa Pro Asn Arg Asn Leu Pro 
    130                 135                 140                 


Xaa Asp Phe Asp Glu Ile Phe Glu Ala Xaa Lys Ala Val Xaa Gln Leu 
145                 150                 155                 160 


Glu Leu Phe Gly Asp Met Ser Xaa Pro Pro Asp Ile Xaa Ser Pro Pro 
                165                 170                 175     


Xaa Pro Ala Xaa Pro Gly Asp Ala Phe Ile Pro Ser Ser Ser Gln Xaa 
            180                 185                 190         


Leu Pro Ala Ser Ala Asp Val Phe Ser Ser Val Pro Phe Gly Xaa Ala 
        195                 200                 205             


Ala Val Pro Ser Gly Tyr Val Ala Met Gly Ala Val Leu Pro Ser Phe 
    210                 215                 220                 


Trp Gly Gln Gln Pro Leu Val Gln Gln Gln Met Val Met Gly Ala 
225                 230                 235                 


<210> 7512
<211> 39
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<400> 7512
Met Ser Asn Glu Val Glu Xaa Ser Ala Xaa Asn Gly Gln Pro Asp Gln 
1               5                   10                  15      


Gln Ala Ala Pro Lys Ala Pro Ser Lys Lys Glu Lys Lys Lys Gly Pro 
            20                  25                  30          


Glu Lys Xaa Asp Glu Tyr Leu 
        35                  


<210> 7513
<211> 67
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<400> 7513
Met Ser Asn Glu Val Glu Xaa Ser Ala Xaa Asn Gly Gln Pro Asp Gln 
1               5                   10                  15      


Gln Ala Ala Pro Lys Ala Pro Ser Lys Lys Glu Lys Lys Lys Gly Pro 
            20                  25                  30          


Glu Lys Xaa Asp Glu Tyr Leu Leu Ala Arg Phe Lys Gly Asp Gly Val 
        35                  40                  45              


Lys Tyr Lys Ala Lys Leu Ile Gly Ile Asp Asp Val Pro Asp Ala Arg 
    50                  55                  60                  


Gly Asp Lys 
65          


<210> 7514
<211> 76
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<400> 7514
Met Ser Asn Glu Val Glu Xaa Ser Ala Xaa Asn Gly Gln Pro Asp Gln 
1               5                   10                  15      


Gln Ala Ala Pro Lys Ala Pro Ser Lys Lys Glu Lys Lys Lys Gly Pro 
            20                  25                  30          


Glu Lys Xaa Asp Glu Tyr Leu Leu Ala Arg Phe Lys Gly Asp Gly Val 
        35                  40                  45              


Lys Tyr Lys Ala Lys Leu Ile Gly Ile Asp Asp Val Pro Asp Ala Arg 
    50                  55                  60                  


Gly Asp Lys Met Ser Gln Asp Ser Met Met Lys Leu 
65                  70                  75      


<210> 7515
<211> 749
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (484)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (486)..(486)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(566)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<400> 7515
Met Ser Asn Glu Val Glu Xaa Ser Ala Xaa Asn Gly Gln Pro Asp Gln 
1               5                   10                  15      


Gln Ala Ala Pro Lys Ala Pro Ser Lys Lys Glu Lys Lys Lys Gly Pro 
            20                  25                  30          


Glu Lys Xaa Asp Glu Tyr Leu Leu Ala Arg Phe Lys Gly Asp Gly Val 
        35                  40                  45              


Lys Tyr Lys Ala Lys Leu Ile Gly Ile Asp Asp Val Pro Asp Ala Arg 
    50                  55                  60                  


Gly Asp Lys Met Ser Gln Asp Ser Met Met Lys Leu Lys Gly Met Ala 
65                  70                  75                  80  


Ala Ala Gly Arg Ser Gln Gly Gln His Lys Gln Arg Ile Trp Val Asn 
                85                  90                  95      


Ile Ser Leu Ser Gly Ile Lys Ile Ile Asp Glu Lys Xaa Gly Val Ile 
            100                 105                 110         


Glu His Glu His Pro Val Asn Lys Ile Ser Phe Ile Ala Arg Asp Val 
        115                 120                 125             


Xaa Asp Asn Arg Ala Phe Gly Tyr Val Cys Gly Gly Glu Gly Gln His 
    130                 135                 140                 


Gln Phe Phe Ala Ile Lys Xaa Gly Gln Gln Ala Glu Pro Leu Val Val 
145                 150                 155                 160 


Asp Leu Lys Asp Leu Phe Gln Val Ile Tyr Asn Val Lys Lys Lys Glu 
                165                 170                 175     


Glu Glu Lys Lys Lys Ile Glu Glu Ala Ser Lys Ala Val Glu Asn Gly 
            180                 185                 190         


Ser Glu Ala Leu Met Ile Leu Asp Asp Gln Xaa Asn Lys Leu Lys Ser 
        195                 200                 205             


Glu Ser Lys Asp Ile Leu Leu Val Asp Leu Asn Ser Glu Ile Asp Xaa 
    210                 215                 220                 


Asn Gln Asn Ser Leu Arg Glu Asn Pro Phe Leu Xaa Asn Gly Ile Xaa 
225                 230                 235                 240 


Ser Cys Ser Leu Pro Arg Pro Xaa Pro Gln Ala Ser Phe Leu Pro Glu 
                245                 250                 255     


Asn Ala Phe Ser Ala Asn Leu Asn Phe Phe Pro Xaa Pro Asn Pro Asp 
            260                 265                 270         


Pro Phe Arg Asp Asp Pro Phe Xaa Gln Pro Asp Gln Ser Xaa Pro Ser 
        275                 280                 285             


Ser Phe Asp Ser Leu Lys Ser Pro Asp Gln Lys Lys Glu Asn Ser Ser 
    290                 295                 300                 


Ser Ser Ser Xaa Pro Leu Ser Asn Gly Pro Leu Asn Gly Asp Val Asp 
305                 310                 315                 320 


Tyr Phe Gly Gln Gln Phe Asp Gln Ile Ser Asn Arg Xaa Gly Lys Gln 
                325                 330                 335     


Glu Ala Gln Ala Gly Pro Trp Pro Phe Ser Ser Ser Gln Xaa Gln Pro 
            340                 345                 350         


Ala Val Arg Xaa Gln Asn Gly Val Ser Glu Arg Glu Gln Asn Gly Phe 
        355                 360                 365             


Ser Val Lys Ser Ser Pro Asn Pro Phe Val Gly Ser Pro Pro Lys Gly 
    370                 375                 380                 


Leu Ser Ile Gln Asn Gly Val Lys Gln Asp Leu Glu Ser Ser Val Gln 
385                 390                 395                 400 


Ser Ser Pro His Asp Ser Ile Ala Ile Ile Pro Pro Pro Gln Ser Xaa 
                405                 410                 415     


Lys Pro Gly Arg Gly Arg Arg Xaa Ala Lys Ser Ser Ala Asn Asp Leu 
            420                 425                 430         


Leu Ala Ser Asp Ile Phe Ala Pro Pro Val Ser Glu Pro Ser Gly Gln 
        435                 440                 445             


Ala Ser Pro Xaa Gly Gln Pro Xaa Ala Leu Gln Pro Asn Pro Leu Asp 
    450                 455                 460                 


Leu Phe Lys Xaa Ser Ala Pro Ala Pro Val Gly Pro Leu Val Gly Leu 
465                 470                 475                 480 


Gly Gly Val Xaa Val Xaa Leu Pro Gln Ala Gly Pro Trp Asn Xaa Ala 
                485                 490                 495     


Ser Leu Val Phe Asn Gln Ser Pro Ser Met Ala Pro Gly Ala Met Met 
            500                 505                 510         


Gly Gly Gln Pro Ser Gly Phe Ser Gln Pro Val Ile Phe Gly Xaa Ser 
        515                 520                 525             


Pro Ala Val Ser Gly Trp Asn Gln Pro Ser Pro Phe Ala Ala Ser Xaa 
    530                 535                 540                 


Pro Pro Pro Val Pro Val Val Trp Gly Pro Ser Ala Ser Val Ala Pro 
545                 550                 555                 560 


Asn Ala Trp Ser Xaa Xaa Ser Pro Leu Gly Asn Pro Phe Gln Ser Asn 
                565                 570                 575     


Ile Phe Pro Ala Pro Ala Val Ser Xaa Gln Pro Pro Ser Met His Ser 
            580                 585                 590         


Ser Leu Leu Val Xaa Pro Pro Gln Pro Pro Pro Arg Ala Gly Pro Pro 
        595                 600                 605             


Lys Asp Ile Ser Ser Asp Ala Phe Xaa Ala Leu Asp Pro Leu Gly Asp 
    610                 615                 620                 


Lys Glu Ile Lys Asp Val Lys Glu Met Phe Lys Asp Phe Gln Leu Arg 
625                 630                 635                 640 


Gln Pro Pro Ala Val Pro Ala Arg Lys Gly Glu Gln Xaa Ser Ser Gly 
                645                 650                 655     


Xaa Leu Ser Ala Phe Ala Ser Tyr Phe Asn Ser Lys Val Gly Ile Pro 
            660                 665                 670         


Gln Glu Asn Ala Asp His Asp Asp Phe Asp Ala Asn Gln Leu Leu Asn 
        675                 680                 685             


Lys Ile Asn Glu Pro Pro Lys Pro Ala Pro Arg Gln Val Ser Leu Pro 
    690                 695                 700                 


Val Xaa Lys Ser Xaa Asp Asn Ala Phe Glu Asn Pro Phe Phe Lys Asp 
705                 710                 715                 720 


Ser Phe Gly Ser Ser Gln Ala Ser Val Ala Ser Ser Gln Pro Val Ser 
                725                 730                 735     


Ser Glu Met Tyr Arg Asp Pro Phe Gly Asn Pro Phe Ala 
            740                 745                 


<210> 7516
<211> 770
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (489)..(489)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (507)..(507)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(587)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (606)..(606)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (638)..(638)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<400> 7516
Met Ser Asn Glu Val Glu Xaa Ser Ala Xaa Asn Gly Gln Pro Asp Gln 
1               5                   10                  15      


Gln Ala Ala Pro Lys Ala Pro Ser Lys Lys Glu Lys Lys Lys Gly Pro 
            20                  25                  30          


Glu Lys Xaa Asp Glu Tyr Leu Leu Ala Arg Phe Lys Gly Asp Gly Val 
        35                  40                  45              


Lys Tyr Lys Ala Lys Leu Ile Gly Ile Asp Asp Val Pro Asp Ala Arg 
    50                  55                  60                  


Gly Asp Lys Met Ser Gln Asp Ser Met Met Lys Leu Lys Gly Met Ala 
65                  70                  75                  80  


Ala Ala Gly Arg Ser Gln Gly Gln His Lys Gln Arg Ile Trp Val Asn 
                85                  90                  95      


Ile Ser Leu Ser Gly Ile Lys Ile Ile Asp Glu Lys Xaa Gly Val Ile 
            100                 105                 110         


Glu His Glu His Pro Val Asn Lys Ile Ser Phe Ile Ala Arg Asp Val 
        115                 120                 125             


Xaa Asp Asn Arg Ala Phe Gly Tyr Val Cys Gly Gly Glu Gly Gln His 
    130                 135                 140                 


Gln Phe Phe Ala Ile Lys Xaa Gly Gln Gln Ala Glu Pro Leu Val Val 
145                 150                 155                 160 


Asp Leu Lys Asp Leu Phe Gln Val Ile Tyr Asn Val Lys Lys Lys Glu 
                165                 170                 175     


Glu Glu Lys Lys Lys Ile Glu Glu Ala Ser Lys Ala Val Glu Asn Gly 
            180                 185                 190         


Ser Glu Ala Leu Met Ile Leu Asp Asp Gln Xaa Asn Lys Leu Lys Ser 
        195                 200                 205             


Gly Val Asp Gln Met Asp Leu Phe Gly Asp Met Ser Xaa Pro Pro Asp 
    210                 215                 220                 


Leu Asn Ser Pro Xaa Glu Ser Lys Asp Ile Leu Leu Val Asp Leu Asn 
225                 230                 235                 240 


Ser Glu Ile Asp Xaa Asn Gln Asn Ser Leu Arg Glu Asn Pro Phe Leu 
                245                 250                 255     


Xaa Asn Gly Ile Xaa Ser Cys Ser Leu Pro Arg Pro Xaa Pro Gln Ala 
            260                 265                 270         


Ser Phe Leu Pro Glu Asn Ala Phe Ser Ala Asn Leu Asn Phe Phe Pro 
        275                 280                 285             


Xaa Pro Asn Pro Asp Pro Phe Arg Asp Asp Pro Phe Xaa Gln Pro Asp 
    290                 295                 300                 


Gln Ser Xaa Pro Ser Ser Phe Asp Ser Leu Lys Ser Pro Asp Gln Lys 
305                 310                 315                 320 


Lys Glu Asn Ser Ser Ser Ser Ser Xaa Pro Leu Ser Asn Gly Pro Leu 
                325                 330                 335     


Asn Gly Asp Val Asp Tyr Phe Gly Gln Gln Phe Asp Gln Ile Ser Asn 
            340                 345                 350         


Arg Xaa Gly Lys Gln Glu Ala Gln Ala Gly Pro Trp Pro Phe Ser Ser 
        355                 360                 365             


Ser Gln Xaa Gln Pro Ala Val Arg Xaa Gln Asn Gly Val Ser Glu Arg 
    370                 375                 380                 


Glu Gln Asn Gly Phe Ser Val Lys Ser Ser Pro Asn Pro Phe Val Gly 
385                 390                 395                 400 


Ser Pro Pro Lys Gly Leu Ser Ile Gln Asn Gly Val Lys Gln Asp Leu 
                405                 410                 415     


Glu Ser Ser Val Gln Ser Ser Pro His Asp Ser Ile Ala Ile Ile Pro 
            420                 425                 430         


Pro Pro Gln Ser Xaa Lys Pro Gly Arg Gly Arg Arg Xaa Ala Lys Ser 
        435                 440                 445             


Ser Ala Asn Asp Leu Leu Ala Ser Asp Ile Phe Ala Pro Pro Val Ser 
    450                 455                 460                 


Glu Pro Ser Gly Gln Ala Ser Pro Xaa Gly Gln Pro Xaa Ala Leu Gln 
465                 470                 475                 480 


Pro Asn Pro Leu Asp Leu Phe Lys Xaa Ser Ala Pro Ala Pro Val Gly 
                485                 490                 495     


Pro Leu Val Gly Leu Gly Gly Val Xaa Val Xaa Leu Pro Gln Ala Gly 
            500                 505                 510         


Pro Trp Asn Xaa Ala Ser Leu Val Phe Asn Gln Ser Pro Ser Met Ala 
        515                 520                 525             


Pro Gly Ala Met Met Gly Gly Gln Pro Ser Gly Phe Ser Gln Pro Val 
    530                 535                 540                 


Ile Phe Gly Xaa Ser Pro Ala Val Ser Gly Trp Asn Gln Pro Ser Pro 
545                 550                 555                 560 


Phe Ala Ala Ser Xaa Pro Pro Pro Val Pro Val Val Trp Gly Pro Ser 
                565                 570                 575     


Ala Ser Val Ala Pro Asn Ala Trp Ser Xaa Xaa Ser Pro Leu Gly Asn 
            580                 585                 590         


Pro Phe Gln Ser Asn Ile Phe Pro Ala Pro Ala Val Ser Xaa Gln Pro 
        595                 600                 605             


Pro Ser Met His Ser Ser Leu Leu Val Xaa Pro Pro Gln Pro Pro Pro 
    610                 615                 620                 


Arg Ala Gly Pro Pro Lys Asp Ile Ser Ser Asp Ala Phe Xaa Ala Leu 
625                 630                 635                 640 


Asp Pro Leu Gly Asp Lys Glu Ile Lys Asp Val Lys Glu Met Phe Lys 
                645                 650                 655     


Asp Phe Gln Leu Arg Gln Pro Pro Ala Val Pro Ala Arg Lys Gly Glu 
            660                 665                 670         


Gln Xaa Ser Ser Gly Xaa Leu Ser Ala Phe Ala Ser Tyr Phe Asn Ser 
        675                 680                 685             


Lys Val Gly Ile Pro Gln Glu Asn Ala Asp His Asp Asp Phe Asp Ala 
    690                 695                 700                 


Asn Gln Leu Leu Asn Lys Ile Asn Glu Pro Pro Lys Pro Ala Pro Arg 
705                 710                 715                 720 


Gln Val Ser Leu Pro Val Xaa Lys Ser Xaa Asp Asn Ala Phe Glu Asn 
                725                 730                 735     


Pro Phe Phe Lys Asp Ser Phe Gly Ser Ser Gln Ala Ser Val Ala Ser 
            740                 745                 750         


Ser Gln Pro Val Ser Ser Glu Met Tyr Arg Asp Pro Phe Gly Asn Pro 
        755                 760                 765             


Phe Ala 
    770 


<210> 7517
<211> 552
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (289)..(289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (368)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<400> 7517
Met Ser Asn Glu Val Glu Xaa Ser Ala Xaa Asn Gly Gln Pro Asp Gln 
1               5                   10                  15      


Gln Ala Ala Pro Lys Ala Pro Ser Lys Lys Glu Lys Lys Lys Gly Pro 
            20                  25                  30          


Glu Lys Xaa Asp Glu Tyr Leu Leu Ala Arg Phe Lys Gly Asp Gly Val 
        35                  40                  45              


Lys Tyr Lys Ala Lys Leu Ile Gly Ile Asp Asp Val Pro Asp Ala Arg 
    50                  55                  60                  


Gly Asp Lys Met Ser Gln Asp Ser Met Met Lys Leu Lys Gly Met Ala 
65                  70                  75                  80  


Ala Ala Gly Arg Ser Gln Gly Gln His Lys Gln Arg Ile Trp Val Asn 
                85                  90                  95      


Ile Ser Leu Ser Gly Ile Lys Ile Ile Asp Glu Lys Xaa Gly Val Ile 
            100                 105                 110         


Glu His Glu His Pro Val Asn Lys Ile Ser Phe Ile Ala Arg Asp Val 
        115                 120                 125             


Xaa Asp Asn Arg Ala Phe Gly Tyr Val Cys Gly Gly Glu Gly Gln His 
    130                 135                 140                 


Gln Phe Phe Ala Ile Lys Xaa Gly Gln Gln Ala Glu Pro Leu Val Val 
145                 150                 155                 160 


Asp Leu Lys Asp Leu Phe Gln Val Ile Tyr Asn Val Lys Lys Lys Glu 
                165                 170                 175     


Glu Glu Lys Lys Lys Ile Glu Glu Ala Ser Lys Ala Val Glu Asn Gly 
            180                 185                 190         


Ser Glu Ala Leu Met Ile Leu Asp Asp Gln Xaa Asn Lys Leu Lys Ser 
        195                 200                 205             


Gly Val Asp Gln Met Asp Leu Phe Gly Asp Met Ser Xaa Pro Pro Asp 
    210                 215                 220                 


Leu Asn Ser Pro Xaa Ser Ser Ala Asn Asp Leu Leu Ala Ser Asp Ile 
225                 230                 235                 240 


Phe Ala Pro Pro Val Ser Glu Pro Ser Gly Gln Ala Ser Pro Xaa Gly 
                245                 250                 255     


Gln Pro Xaa Ala Leu Gln Pro Asn Pro Leu Asp Leu Phe Lys Xaa Ser 
            260                 265                 270         


Ala Pro Ala Pro Val Gly Pro Leu Val Gly Leu Gly Gly Val Xaa Val 
        275                 280                 285             


Xaa Leu Pro Gln Ala Gly Pro Trp Asn Xaa Ala Ser Leu Val Phe Asn 
    290                 295                 300                 


Gln Ser Pro Ser Met Ala Pro Gly Ala Met Met Gly Gly Gln Pro Ser 
305                 310                 315                 320 


Gly Phe Ser Gln Pro Val Ile Phe Gly Xaa Ser Pro Ala Val Ser Gly 
                325                 330                 335     


Trp Asn Gln Pro Ser Pro Phe Ala Ala Ser Xaa Pro Pro Pro Val Pro 
            340                 345                 350         


Val Val Trp Gly Pro Ser Ala Ser Val Ala Pro Asn Ala Trp Ser Xaa 
        355                 360                 365             


Xaa Ser Pro Leu Gly Asn Pro Phe Gln Ser Asn Ile Phe Pro Ala Pro 
    370                 375                 380                 


Ala Val Ser Xaa Gln Pro Pro Ser Met His Ser Ser Leu Leu Val Xaa 
385                 390                 395                 400 


Pro Pro Gln Pro Pro Pro Arg Ala Gly Pro Pro Lys Asp Ile Ser Ser 
                405                 410                 415     


Asp Ala Phe Xaa Ala Leu Asp Pro Leu Gly Asp Lys Glu Ile Lys Asp 
            420                 425                 430         


Val Lys Glu Met Phe Lys Asp Phe Gln Leu Arg Gln Pro Pro Ala Val 
        435                 440                 445             


Pro Ala Arg Lys Gly Glu Gln Xaa Ser Ser Gly Xaa Leu Ser Ala Phe 
    450                 455                 460                 


Ala Ser Tyr Phe Asn Ser Lys Val Gly Ile Pro Gln Glu Asn Ala Asp 
465                 470                 475                 480 


His Asp Asp Phe Asp Ala Asn Gln Leu Leu Asn Lys Ile Asn Glu Pro 
                485                 490                 495     


Pro Lys Pro Ala Pro Arg Gln Val Ser Leu Pro Val Xaa Lys Ser Xaa 
            500                 505                 510         


Asp Asn Ala Phe Glu Asn Pro Phe Phe Lys Asp Ser Phe Gly Ser Ser 
        515                 520                 525             


Gln Ala Ser Val Ala Ser Ser Gln Pro Val Ser Ser Glu Met Tyr Arg 
    530                 535                 540                 


Asp Pro Phe Gly Asn Pro Phe Ala 
545                 550         


<210> 7518
<211> 116
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<400> 7518
Met Ser Asn Glu Val Glu Xaa Ser Ala Xaa Asn Gly Gln Pro Asp Gln 
1               5                   10                  15      


Gln Ala Ala Pro Lys Ala Pro Ser Lys Lys Glu Lys Lys Lys Gly Pro 
            20                  25                  30          


Glu Lys Xaa Asp Glu Tyr Leu Leu Ala Arg Phe Lys Gly Asp Gly Val 
        35                  40                  45              


Lys Tyr Lys Ala Lys Leu Ile Gly Ile Asp Asp Val Pro Asp Ala Arg 
    50                  55                  60                  


Gly Asp Lys Met Ser Gln Asp Ser Met Met Lys Leu Lys Gly Met Ala 
65                  70                  75                  80  


Ala Ala Gly Arg Ser Gln Gly Gln His Lys Gln Arg Ile Trp Val Asn 
                85                  90                  95      


Ile Ser Leu Ser Gly Ile Lys Ile Ile Asp Glu Lys Xaa Gly Val Arg 
            100                 105                 110         


Ile His Ile Cys 
        115     


<210> 7519
<211> 291
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<400> 7519
Met Glu Pro Asp Ser Leu Leu Asp Gln Asp Asp Ser Tyr Glu Ser Pro 
1               5                   10                  15      


Gln Glu Arg Pro Gly Ser Arg Arg Ser Leu Pro Gly Ser Leu Ser Glu 
            20                  25                  30          


Lys Ser Pro Ser Met Glu Pro Ser Ala Ala Xaa Pro Phe Arg Val Xaa 
        35                  40                  45              


Gly Phe Leu Ser Arg Arg Leu Lys Gly Ser Ile Lys Arg Xaa Lys Ser 
    50                  55                  60                  


Gln Pro Lys Leu Asp Arg Asn His Ser Phe Arg His Ile Leu Pro Gly 
65                  70                  75                  80  


Phe Arg Ser Ala Ala Ala Ala Ala Ala Asp Asn Glu Arg Ser His Leu 
                85                  90                  95      


Met Pro Arg Leu Lys Glu Ser Arg Ser His Glu Ser Leu Leu Ser Pro 
            100                 105                 110         


Ser Ser Ala Val Glu Ala Leu Asp Leu Ser Met Glu Glu Glu Val Val 
        115                 120                 125             


Ile Lys Pro Val His Ser Ser Ile Leu Gly Gln Asp Tyr Cys Phe Glu 
    130                 135                 140                 


Val Xaa Xaa Ser Ser Gly Ser Lys Cys Phe Ser Cys Arg Ser Ala Ala 
145                 150                 155                 160 


Glu Arg Asp Lys Trp Met Glu Asn Leu Arg Arg Ala Val His Pro Asn 
                165                 170                 175     


Lys Asp Asn Ser Arg Arg Val Glu His Ile Leu Lys Leu Trp Val Ile 
            180                 185                 190         


Glu Ala Lys Asp Leu Pro Ala Lys Lys Lys Tyr Leu Cys Glu Leu Cys 
        195                 200                 205             


Leu Asp Asp Val Leu Tyr Ala Arg Xaa Xaa Gly Lys Leu Lys Xaa Asp 
    210                 215                 220                 


Asn Val Phe Trp Gly Glu His Phe Glu Phe His Asn Leu Pro Pro Leu 
225                 230                 235                 240 


Arg Xaa Val Xaa Val His Leu Tyr Arg Glu Xaa Asp Lys Lys Lys Lys 
                245                 250                 255     


Lys Glu Arg Asn Ser Tyr Leu Gly Leu Val Ser Leu Pro Ala Ala Ser 
            260                 265                 270         


Val Ala Gly Arg Gln Phe Val Glu Lys Trp Tyr Pro Val Val Xaa Pro 
        275                 280                 285             


Asn Pro Lys 
    290     


<210> 7520
<211> 1132
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (287)..(287)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (308)..(308)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (642)..(642)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (686)..(686)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (849)..(849)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (869)..(869)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (914)..(914)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (924)..(924)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (974)..(974)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1041)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1125)..(1125)
<223> Selenocysteine

<400> 7520
Met Glu Pro Asp Ser Leu Leu Asp Gln Asp Asp Ser Tyr Glu Ser Pro 
1               5                   10                  15      


Gln Glu Arg Pro Gly Ser Arg Arg Ser Leu Pro Gly Ser Leu Ser Glu 
            20                  25                  30          


Lys Ser Pro Ser Met Glu Pro Ser Ala Ala Xaa Pro Phe Arg Val Xaa 
        35                  40                  45              


Gly Phe Leu Ser Arg Arg Leu Lys Gly Ser Ile Lys Arg Xaa Lys Ser 
    50                  55                  60                  


Gln Pro Lys Leu Asp Arg Asn His Ser Phe Arg His Ile Leu Pro Gly 
65                  70                  75                  80  


Phe Arg Ser Ala Ala Ala Ala Ala Ala Asp Asn Glu Arg Ser His Leu 
                85                  90                  95      


Met Pro Arg Leu Lys Glu Ser Arg Ser His Glu Ser Leu Leu Ser Pro 
            100                 105                 110         


Ser Ser Ala Val Glu Ala Leu Asp Leu Ser Met Glu Glu Glu Val Val 
        115                 120                 125             


Ile Lys Pro Val His Ser Ser Ile Leu Gly Gln Asp Tyr Cys Phe Glu 
    130                 135                 140                 


Val Xaa Xaa Ser Ser Gly Ser Lys Cys Phe Ser Cys Arg Ser Ala Ala 
145                 150                 155                 160 


Glu Arg Asp Lys Trp Met Glu Asn Leu Arg Arg Ala Val His Pro Asn 
                165                 170                 175     


Lys Asp Asn Ser Arg Arg Val Glu His Ile Leu Lys Leu Trp Val Ile 
            180                 185                 190         


Glu Ala Lys Asp Leu Pro Ala Lys Lys Lys Tyr Leu Cys Glu Leu Cys 
        195                 200                 205             


Leu Asp Asp Val Leu Tyr Ala Arg Xaa Xaa Gly Lys Leu Lys Xaa Asp 
    210                 215                 220                 


Asn Val Phe Trp Gly Glu His Phe Glu Phe His Asn Leu Pro Pro Leu 
225                 230                 235                 240 


Arg Xaa Val Xaa Val His Leu Tyr Arg Glu Xaa Asp Lys Lys Lys Lys 
                245                 250                 255     


Lys Glu Arg Asn Ser Tyr Leu Gly Leu Val Ser Leu Pro Ala Ala Ser 
            260                 265                 270         


Val Ala Gly Arg Gln Phe Val Glu Lys Trp Tyr Pro Val Val Xaa Pro 
        275                 280                 285             


Asn Pro Lys Gly Gly Lys Gly Pro Gly Pro Met Ile Arg Ile Lys Ala 
    290                 295                 300                 


Arg Tyr Gln Xaa Ile Xaa Ile Leu Pro Met Glu Met Tyr Lys Glu Phe 
305                 310                 315                 320 


Ala Glu His Ile Xaa Asn His Tyr Leu Gly Leu Cys Ala Ala Leu Glu 
                325                 330                 335     


Pro Ile Leu Ser Ala Lys Xaa Lys Glu Glu Met Ala Ser Ala Leu Val 
            340                 345                 350         


His Ile Leu Gln Ser Xaa Gly Lys Val Lys Asp Phe Leu Xaa Asp Leu 
        355                 360                 365             


Met Met Ser Glu Val Asp Arg Cys Gly Asp Asn Glu His Leu Ile Phe 
    370                 375                 380                 


Arg Glu Asn Xaa Leu Ala Xaa Lys Ala Ile Glu Glu Tyr Leu Lys Leu 
385                 390                 395                 400 


Val Gly Gln Lys Tyr Leu Gln Asp Ala Leu Gly Glu Phe Ile Lys Ala 
                405                 410                 415     


Leu Tyr Glu Ser Asp Glu Asn Cys Glu Val Asp Pro Ser Lys Cys Ser 
            420                 425                 430         


Ala Ala Asp Leu Pro Glu His Gln Gly Asn Leu Lys Met Cys Cys Glu 
        435                 440                 445             


Leu Ala Phe Cys Lys Ile Ile Asn Ser Tyr Cys Val Phe Pro Arg Glu 
    450                 455                 460                 


Leu Lys Glu Val Phe Ala Ser Trp Arg Gln Glu Cys Ser Ser Arg Gly 
465                 470                 475                 480 


Arg Pro Asp Ile Ser Glu Arg Leu Ile Ser Ala Ser Leu Phe Leu Arg 
                485                 490                 495     


Phe Leu Cys Pro Ala Ile Met Ser Pro Ser Leu Phe Asn Leu Leu Gln 
            500                 505                 510         


Glu Tyr Pro Asp Asp Arg Xaa Ala Arg Xaa Leu Xaa Leu Ile Ala Lys 
        515                 520                 525             


Val Xaa Gln Asn Leu Ala Asn Phe Ala Lys Phe Gly Ser Lys Glu Glu 
    530                 535                 540                 


Tyr Met Ser Phe Met Asn Gln Phe Leu Glu His Glu Trp Xaa Asn Met 
545                 550                 555                 560 


Gln Arg Phe Leu Leu Glu Ile Ser Asn Pro Glu Xaa Leu Ser Asn Xaa 
                565                 570                 575     


Ala Gly Phe Glu Gly Tyr Ile Asp Leu Gly Arg Glu Leu Ser Ser Leu 
            580                 585                 590         


His Ser Leu Leu Trp Glu Ala Val Ser Gln Leu Glu Gln Ser Ile Val 
        595                 600                 605             


Ser Lys Leu Gly Pro Leu Pro Arg Ile Leu Arg Asp Val His Xaa Ala 
    610                 615                 620                 


Leu Ser Xaa Pro Gly Ser Gly Gln Leu Pro Gly Xaa Asn Asp Leu Ala 
625                 630                 635                 640 


Ser Xaa Pro Gly Ser Gly Ser Ser Ser Ile Ser Ala Gly Leu Gln Lys 
                645                 650                 655     


Met Val Ile Glu Asn Asp Leu Ser Gly Leu Ile Asp Phe Xaa Arg Leu 
            660                 665                 670         


Pro Ser Pro Xaa Pro Glu Asn Lys Asp Leu Phe Phe Val Xaa Arg Ser 
        675                 680                 685             


Ser Gly Val Gln Pro Ser Pro Ala Arg Ser Ser Ser Tyr Ser Glu Ala 
    690                 695                 700                 


Asn Glu Pro Asp Leu Gln Met Ala Asn Gly Gly Lys Ser Leu Ser Met 
705                 710                 715                 720 


Val Asp Leu Gln Asp Ala Arg Xaa Leu Asp Gly Glu Ala Gly Ser Pro 
                725                 730                 735     


Ala Gly Pro Asp Val Leu Pro Xaa Asp Gly Gln Ala Ala Ala Ala Gln 
            740                 745                 750         


Leu Val Ala Gly Trp Pro Ala Arg Ala Xaa Pro Val Asn Leu Ala Gly 
        755                 760                 765             


Leu Ala Xaa Val Arg Arg Ala Gly Gln Xaa Pro Xaa Xaa Pro Gly Xaa 
    770                 775                 780                 


Ser Glu Gly Ala Pro Gly Arg Pro Gln Leu Leu Ala Pro Leu Ser Phe 
785                 790                 795                 800 


Gln Asn Pro Val Tyr Gln Met Ala Ala Gly Leu Pro Leu Ser Pro Arg 
                805                 810                 815     


Gly Leu Gly Asp Ser Gly Ser Glu Gly His Ser Ser Leu Ser Ser His 
            820                 825                 830         


Ser Asn Ser Glu Glu Leu Ala Ala Ala Ala Lys Leu Gly Ser Phe Ser 
        835                 840                 845             


Xaa Ala Ala Glu Glu Leu Ala Arg Arg Pro Gly Glu Leu Ala Arg Arg 
    850                 855                 860                 


Gln Met Ser Leu Xaa Glu Lys Gly Gly Gln Pro Xaa Val Pro Arg Gln 
865                 870                 875                 880 


Asn Ser Ala Gly Pro Gln Arg Arg Ile Asp Gln Pro Pro Pro Pro Pro 
                885                 890                 895     


Pro Pro Pro Pro Pro Ala Pro Arg Gly Arg Xaa Pro Pro Asn Leu Leu 
            900                 905                 910         


Ser Xaa Leu Gln Tyr Pro Arg Pro Ser Ser Gly Xaa Leu Ala Ser Ala 
        915                 920                 925             


Ser Pro Asp Trp Val Gly Pro Ser Xaa Arg Leu Arg Gln Gln Ser Ser 
    930                 935                 940                 


Ser Ser Lys Gly Asp Ser Pro Glu Leu Lys Pro Arg Ala Val His Lys 
945                 950                 955                 960 


Gln Gly Pro Ser Pro Val Ser Pro Asn Ala Leu Asp Arg Xaa Ala Ala 
                965                 970                 975     


Trp Leu Leu Xaa Met Asn Ala Gln Leu Leu Glu Asp Glu Gly Leu Gly 
            980                 985                 990         


Pro Asp Pro Pro His Arg Asp Arg  Leu Arg Ser Lys Asp  Glu Leu Ser 
        995                 1000                 1005             


Gln Ala  Glu Lys Asp Leu Ala  Val Leu Gln Asp Lys  Leu Arg Ile 
    1010                 1015                 1020             


Ser Xaa  Lys Lys Leu Glu Glu  Tyr Glu Xaa Leu Phe  Lys Cys Gln 
    1025                 1030                 1035             


Glu Glu  Xaa Xaa Gln Lys Leu  Val Leu Glu Tyr Gln  Ala Arg Leu 
    1040                 1045                 1050             


Glu Glu  Gly Glu Glu Arg Leu  Arg Arg Gln Gln Glu  Asp Lys Asp 
    1055                 1060                 1065             


Ile Gln  Met Lys Gly Ile Ile  Ser Arg Leu Met Ser  Val Glu Glu 
    1070                 1075                 1080             


Glu Leu  Lys Lys Asp His Ala  Glu Met Gln Ala Ala  Val Asp Ser 
    1085                 1090                 1095             


Lys Gln  Lys Ile Ile Asp Ala  Gln Glu Lys Arg Ile  Ala Ser Leu 
    1100                 1105                 1110             


Asp Ala  Ala Asn Ala Arg Leu  Met Ser Ala Leu Xaa  Gln Leu Lys 
    1115                 1120                 1125             


Glu Ser  Met His 
    1130         


<210> 7521
<211> 229
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<400> 7521
Met Pro Arg Leu Lys Glu Ser Arg Ser His Glu Ser Leu Leu Ser Pro 
1               5                   10                  15      


Ser Ser Ala Val Glu Ala Leu Asp Leu Ser Met Glu Glu Glu Val Val 
            20                  25                  30          


Ile Lys Pro Val His Ser Ser Ile Leu Gly Gln Asp Tyr Cys Phe Glu 
        35                  40                  45              


Val Xaa Xaa Ser Ser Gly Ser Lys Cys Phe Ser Cys Arg Ser Ala Ala 
    50                  55                  60                  


Glu Arg Asp Lys Trp Met Glu Asn Leu Arg Arg Ala Val His Pro Asn 
65                  70                  75                  80  


Lys Asp Asn Ser Arg Arg Val Glu His Ile Leu Lys Leu Trp Val Ile 
                85                  90                  95      


Glu Ala Lys Asp Leu Pro Ala Lys Lys Lys Tyr Leu Cys Glu Leu Cys 
            100                 105                 110         


Leu Asp Asp Val Leu Tyr Ala Arg Xaa Xaa Gly Lys Leu Lys Xaa Asp 
        115                 120                 125             


Asn Val Phe Trp Gly Glu His Phe Glu Phe His Asn Leu Pro Pro Leu 
    130                 135                 140                 


Arg Xaa Val Xaa Val His Leu Tyr Arg Glu Xaa Asp Lys Lys Lys Lys 
145                 150                 155                 160 


Lys Glu Arg Asn Ser Tyr Leu Gly Leu Val Ser Leu Pro Ala Ala Ser 
                165                 170                 175     


Val Ala Gly Arg Gln Phe Val Glu Lys Trp Tyr Pro Val Val Xaa Pro 
            180                 185                 190         


Asn Pro Lys Gly Gly Lys Gly Pro Gly Pro Met Ile Arg Ile Lys Ala 
        195                 200                 205             


Arg Tyr Gln Xaa Ile Xaa Ile Leu Pro Met Glu Met Tyr Lys Glu Phe 
    210                 215                 220                 


Ala Glu His Ile Xaa 
225                 


<210> 7522
<211> 1065
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (50)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (426)..(426)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (666)..(666)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (682)..(682)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(685)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (811)..(811)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (818)..(818)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (929)..(929)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (937)..(937)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (945)..(946)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1029)..(1029)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1049)..(1049)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1054)..(1054)
<223> Selenocysteine

<400> 7522
Met Pro Arg Leu Lys Glu Ser Arg Ser His Glu Ser Leu Leu Ser Pro 
1               5                   10                  15      


Ser Ser Ala Val Glu Ala Leu Asp Leu Ser Met Glu Glu Glu Val Val 
            20                  25                  30          


Ile Lys Pro Val His Ser Ser Ile Leu Gly Gln Asp Tyr Cys Phe Glu 
        35                  40                  45              


Val Xaa Xaa Ser Ser Gly Ser Lys Cys Phe Ser Cys Arg Ser Ala Ala 
    50                  55                  60                  


Glu Arg Asp Lys Trp Met Glu Asn Leu Arg Arg Ala Val His Pro Asn 
65                  70                  75                  80  


Lys Asp Asn Ser Arg Arg Val Glu His Ile Leu Lys Leu Trp Val Ile 
                85                  90                  95      


Glu Ala Lys Asp Leu Pro Ala Lys Lys Lys Tyr Leu Cys Glu Leu Cys 
            100                 105                 110         


Leu Asp Asp Val Leu Tyr Ala Arg Xaa Xaa Gly Lys Leu Lys Xaa Asp 
        115                 120                 125             


Asn Val Phe Trp Gly Glu His Phe Glu Phe His Asn Leu Pro Pro Leu 
    130                 135                 140                 


Arg Xaa Val Xaa Val His Leu Tyr Arg Glu Xaa Asp Lys Lys Lys Lys 
145                 150                 155                 160 


Lys Glu Arg Asn Ser Tyr Leu Gly Leu Val Ser Leu Pro Ala Ala Ser 
                165                 170                 175     


Val Ala Gly Arg Gln Phe Val Glu Lys Trp Tyr Pro Val Val Xaa Pro 
            180                 185                 190         


Asn Pro Lys Gly Gly Lys Gly Pro Gly Pro Met Ile Arg Ile Lys Ala 
        195                 200                 205             


Arg Tyr Gln Xaa Ile Xaa Ile Leu Pro Met Glu Met Tyr Lys Glu Phe 
    210                 215                 220                 


Ala Glu His Ile Xaa Asn His Tyr Leu Gly Leu Cys Ala Ala Leu Glu 
225                 230                 235                 240 


Pro Ile Leu Ser Ala Lys Xaa Lys Glu Glu Met Ala Ser Ala Leu Val 
                245                 250                 255     


His Ile Leu Gln Ser Xaa Gly Lys Val Lys Asp Phe Leu Xaa Asp Leu 
            260                 265                 270         


Met Met Ser Glu Val Asp Arg Cys Gly Asp Asn Glu His Leu Ile Phe 
        275                 280                 285             


Arg Glu Asn Xaa Leu Ala Xaa Lys Ala Ile Glu Glu Tyr Leu Lys Leu 
    290                 295                 300                 


Val Gly Gln Lys Tyr Leu Gln Asp Ala Leu Gly Glu Phe Ile Lys Ala 
305                 310                 315                 320 


Leu Tyr Glu Ser Asp Glu Asn Cys Glu Val Asp Pro Ser Lys Cys Ser 
                325                 330                 335     


Ala Ala Asp Leu Pro Glu His Gln Gly Asn Leu Lys Met Cys Cys Glu 
            340                 345                 350         


Leu Ala Phe Cys Lys Ile Ile Asn Ser Tyr Cys Val Phe Pro Arg Glu 
        355                 360                 365             


Leu Lys Glu Val Phe Ala Ser Trp Arg Gln Glu Cys Ser Ser Arg Gly 
    370                 375                 380                 


Arg Pro Asp Ile Ser Glu Arg Leu Ile Ser Ala Ser Leu Phe Leu Arg 
385                 390                 395                 400 


Phe Leu Cys Pro Ala Ile Met Ser Pro Ser Leu Phe Asn Leu Leu Gln 
                405                 410                 415     


Glu Tyr Pro Asp Asp Arg Xaa Ala Arg Xaa Leu Xaa Leu Ile Ala Lys 
            420                 425                 430         


Val Xaa Gln Asn Leu Ala Asn Phe Ala Lys Phe Gly Ser Lys Glu Glu 
        435                 440                 445             


Tyr Met Ser Phe Met Asn Gln Phe Leu Glu His Glu Trp Xaa Asn Met 
    450                 455                 460                 


Gln Arg Phe Leu Leu Glu Ile Ser Asn Pro Glu Xaa Leu Ser Asn Xaa 
465                 470                 475                 480 


Ala Gly Phe Glu Gly Tyr Ile Asp Leu Gly Arg Glu Leu Ser Ser Leu 
                485                 490                 495     


His Ser Leu Leu Trp Glu Ala Val Ser Gln Leu Glu Gln Ser Ile Val 
            500                 505                 510         


Ser Lys Leu Gly Pro Leu Pro Arg Ile Leu Arg Asp Val His Xaa Ala 
        515                 520                 525             


Leu Ser Xaa Pro Gly Ser Gly Gln Leu Pro Gly Xaa Asn Asp Leu Ala 
    530                 535                 540                 


Ser Xaa Pro Gly Ser Gly Ser Ser Ser Ile Ser Ala Gly Leu Gln Lys 
545                 550                 555                 560 


Met Val Ile Glu Asn Asp Leu Ser Gly Leu Ile Asp Phe Xaa Arg Leu 
                565                 570                 575     


Pro Ser Pro Xaa Pro Glu Asn Lys Asp Leu Phe Phe Val Xaa Arg Ser 
            580                 585                 590         


Ser Gly Val Gln Pro Ser Pro Ala Arg Ser Ser Ser Tyr Ser Glu Ala 
        595                 600                 605             


Asn Glu Pro Asp Leu Gln Met Ala Asn Gly Gly Lys Ser Leu Ser Met 
    610                 615                 620                 


Val Asp Leu Gln Asp Ala Arg Xaa Leu Asp Gly Glu Ala Gly Ser Pro 
625                 630                 635                 640 


Ala Gly Pro Asp Val Leu Pro Xaa Asp Gly Gln Ala Ala Ala Ala Gln 
                645                 650                 655     


Leu Val Ala Gly Trp Pro Ala Arg Ala Xaa Pro Val Asn Leu Ala Gly 
            660                 665                 670         


Leu Ala Xaa Val Arg Arg Ala Gly Gln Xaa Pro Xaa Xaa Pro Gly Xaa 
        675                 680                 685             


Ser Glu Gly Ala Pro Gly Arg Pro Gln Leu Leu Ala Pro Leu Ser Phe 
    690                 695                 700                 


Gln Asn Pro Val Tyr Gln Met Ala Ala Gly Leu Pro Leu Ser Pro Arg 
705                 710                 715                 720 


Gly Leu Gly Asp Ser Gly Ser Glu Gly His Ser Ser Leu Ser Ser His 
                725                 730                 735     


Ser Asn Ser Glu Glu Leu Ala Ala Ala Ala Lys Leu Gly Ser Phe Ser 
            740                 745                 750         


Xaa Ala Ala Glu Glu Leu Ala Arg Arg Pro Gly Glu Leu Ala Arg Arg 
        755                 760                 765             


Gln Met Ser Leu Xaa Glu Lys Gly Gly Gln Pro Xaa Val Pro Arg Gln 
    770                 775                 780                 


Asn Ser Ala Gly Pro Gln Arg Arg Ile Asp Gln Pro Pro Pro Pro Pro 
785                 790                 795                 800 


Pro Pro Pro Pro Pro Ala Pro Arg Gly Arg Xaa Pro Pro Asn Leu Leu 
                805                 810                 815     


Ser Xaa Leu Gln Tyr Pro Arg Pro Ser Ser Gly Xaa Leu Ala Ser Ala 
            820                 825                 830         


Ser Pro Asp Trp Val Gly Pro Ser Xaa Arg Leu Arg Gln Gln Ser Ser 
        835                 840                 845             


Ser Ser Lys Gly Asp Ser Pro Glu Leu Lys Pro Arg Ala Val His Lys 
    850                 855                 860                 


Gln Gly Pro Ser Pro Val Ser Pro Asn Ala Leu Asp Arg Xaa Ala Ala 
865                 870                 875                 880 


Trp Leu Leu Xaa Met Asn Ala Gln Leu Leu Glu Asp Glu Gly Leu Gly 
                885                 890                 895     


Pro Asp Pro Pro His Arg Asp Arg Leu Arg Ser Lys Asp Glu Leu Ser 
            900                 905                 910         


Gln Ala Glu Lys Asp Leu Ala Val Leu Gln Asp Lys Leu Arg Ile Ser 
        915                 920                 925             


Xaa Lys Lys Leu Glu Glu Tyr Glu Xaa Leu Phe Lys Cys Gln Glu Glu 
    930                 935                 940                 


Xaa Xaa Gln Lys Leu Val Leu Glu Tyr Gln Ala Arg Leu Glu Glu Gly 
945                 950                 955                 960 


Glu Glu Arg Leu Arg Arg Gln Gln Glu Asp Lys Asp Ile Gln Met Lys 
                965                 970                 975     


Gly Ile Ile Ser Arg Leu Met Ser Val Glu Glu Glu Leu Lys Lys Asp 
            980                 985                 990         


His Ala Glu Met Gln Ala Ala Val  Asp Ser Lys Gln Lys  Ile Ile Asp 
        995                 1000                 1005             


Ala Gln  Glu Lys Arg Ile Ala  Ser Leu Asp Ala Ala  Asn Ala Arg 
    1010                 1015                 1020             


Leu Met  Ser Ala Leu Xaa Gln  Leu Lys Glu Arg Tyr  Ser Met Gln 
    1025                 1030                 1035             


Ala Arg  Asn Gly Ile Ser Pro  Xaa Asn Pro Xaa Lys  Leu Gln Ile 
    1040                 1045                 1050             


Xaa Glu  Asn Gly Glu Phe Arg  Asn Ser Ser Asn Cys  
    1055                 1060                 1065 


<210> 7523
<211> 1189
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (338)..(338)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (547)..(547)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (552)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (558)..(558)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (586)..(586)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (604)..(604)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(809)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (877)..(877)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (904)..(904)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (935)..(935)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (942)..(942)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (965)..(965)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1061)..(1061)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1069)..(1070)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1173)..(1173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1178)..(1178)
<223> Selenocysteine

<400> 7523
Met Ser Ala Gly Gly Ser Ala Arg Lys Ser Xaa Gly Arg Ser Ser Tyr 
1               5                   10                  15      


Tyr Tyr Arg Leu Leu Arg Arg Pro Arg Leu Gln Arg Gln Arg Ser Arg 
            20                  25                  30          


Ser Arg Ser Arg Xaa Arg Pro Ala Arg Glu Ser Pro Gln Glu Arg Pro 
        35                  40                  45              


Gly Ser Arg Arg Ser Leu Pro Gly Ser Leu Ser Glu Lys Ser Pro Ser 
    50                  55                  60                  


Met Glu Pro Ser Ala Ala Xaa Pro Phe Arg Val Xaa Gly Phe Leu Ser 
65                  70                  75                  80  


Arg Arg Leu Lys Gly Ser Ile Lys Arg Xaa Lys Ser Gln Pro Lys Leu 
                85                  90                  95      


Asp Arg Asn His Ser Phe Arg His Ile Leu Pro Gly Phe Arg Ser Ala 
            100                 105                 110         


Ala Ala Ala Ala Ala Asp Asn Glu Arg Ser His Leu Met Pro Arg Leu 
        115                 120                 125             


Lys Glu Ser Arg Ser His Glu Ser Leu Leu Ser Pro Ser Ser Ala Val 
    130                 135                 140                 


Glu Ala Leu Asp Leu Ser Met Glu Glu Glu Val Val Ile Lys Pro Val 
145                 150                 155                 160 


His Ser Ser Ile Leu Gly Gln Asp Tyr Cys Phe Glu Val Xaa Xaa Ser 
                165                 170                 175     


Ser Gly Ser Lys Cys Phe Ser Cys Arg Ser Ala Ala Glu Arg Asp Lys 
            180                 185                 190         


Trp Met Glu Asn Leu Arg Arg Ala Val His Pro Asn Lys Asp Asn Ser 
        195                 200                 205             


Arg Arg Val Glu His Ile Leu Lys Leu Trp Val Ile Glu Ala Lys Asp 
    210                 215                 220                 


Leu Pro Ala Lys Lys Lys Tyr Leu Cys Glu Leu Cys Leu Asp Asp Val 
225                 230                 235                 240 


Leu Tyr Ala Arg Xaa Xaa Gly Lys Leu Lys Xaa Asp Asn Val Phe Trp 
                245                 250                 255     


Gly Glu His Phe Glu Phe His Asn Leu Pro Pro Leu Arg Xaa Val Xaa 
            260                 265                 270         


Val His Leu Tyr Arg Glu Xaa Asp Lys Lys Lys Lys Lys Glu Arg Asn 
        275                 280                 285             


Ser Tyr Leu Gly Leu Val Ser Leu Pro Ala Ala Ser Val Ala Gly Arg 
    290                 295                 300                 


Gln Phe Val Glu Lys Trp Tyr Pro Val Val Xaa Pro Asn Pro Lys Gly 
305                 310                 315                 320 


Gly Lys Gly Pro Gly Pro Met Ile Arg Ile Lys Ala Arg Tyr Gln Xaa 
                325                 330                 335     


Ile Xaa Ile Leu Pro Met Glu Met Tyr Lys Glu Phe Ala Glu His Ile 
            340                 345                 350         


Xaa Asn His Tyr Leu Gly Leu Cys Ala Ala Leu Glu Pro Ile Leu Ser 
        355                 360                 365             


Ala Lys Xaa Lys Glu Glu Met Ala Ser Ala Leu Val His Ile Leu Gln 
    370                 375                 380                 


Ser Xaa Gly Lys Val Lys Asp Phe Leu Xaa Asp Leu Met Met Ser Glu 
385                 390                 395                 400 


Val Asp Arg Cys Gly Asp Asn Glu His Leu Ile Phe Arg Glu Asn Xaa 
                405                 410                 415     


Leu Ala Xaa Lys Ala Ile Glu Glu Tyr Leu Lys Leu Val Gly Gln Lys 
            420                 425                 430         


Tyr Leu Gln Asp Ala Leu Gly Glu Phe Ile Lys Ala Leu Tyr Glu Ser 
        435                 440                 445             


Asp Glu Asn Cys Glu Val Asp Pro Ser Lys Cys Ser Ala Ala Asp Leu 
    450                 455                 460                 


Pro Glu His Gln Gly Asn Leu Lys Met Cys Cys Glu Leu Ala Phe Cys 
465                 470                 475                 480 


Lys Ile Ile Asn Ser Tyr Cys Val Phe Pro Arg Glu Leu Lys Glu Val 
                485                 490                 495     


Phe Ala Ser Trp Arg Gln Glu Cys Ser Ser Arg Gly Arg Pro Asp Ile 
            500                 505                 510         


Ser Glu Arg Leu Ile Ser Ala Ser Leu Phe Leu Arg Phe Leu Cys Pro 
        515                 520                 525             


Ala Ile Met Ser Pro Ser Leu Phe Asn Leu Leu Gln Glu Tyr Pro Asp 
    530                 535                 540                 


Asp Arg Xaa Ala Arg Xaa Leu Xaa Leu Ile Ala Lys Val Xaa Gln Asn 
545                 550                 555                 560 


Leu Ala Asn Phe Ala Lys Phe Gly Ser Lys Glu Glu Tyr Met Ser Phe 
                565                 570                 575     


Met Asn Gln Phe Leu Glu His Glu Trp Xaa Asn Met Gln Arg Phe Leu 
            580                 585                 590         


Leu Glu Ile Ser Asn Pro Glu Xaa Leu Ser Asn Xaa Ala Gly Phe Glu 
        595                 600                 605             


Gly Tyr Ile Asp Leu Gly Arg Glu Leu Ser Ser Leu His Ser Leu Leu 
    610                 615                 620                 


Trp Glu Ala Val Ser Gln Leu Glu Gln Ser Ile Val Ser Lys Leu Gly 
625                 630                 635                 640 


Pro Leu Pro Arg Ile Leu Arg Asp Val His Xaa Ala Leu Ser Xaa Pro 
                645                 650                 655     


Gly Ser Gly Gln Leu Pro Gly Xaa Asn Asp Leu Ala Ser Xaa Pro Gly 
            660                 665                 670         


Ser Gly Ser Ser Ser Ile Ser Ala Gly Leu Gln Lys Met Val Ile Glu 
        675                 680                 685             


Asn Asp Leu Ser Gly Leu Ile Asp Phe Xaa Arg Leu Pro Ser Pro Xaa 
    690                 695                 700                 


Pro Glu Asn Lys Asp Leu Phe Phe Val Xaa Arg Ser Ser Gly Val Gln 
705                 710                 715                 720 


Pro Ser Pro Ala Arg Ser Ser Ser Tyr Ser Glu Ala Asn Glu Pro Asp 
                725                 730                 735     


Leu Gln Met Ala Asn Gly Gly Lys Ser Leu Ser Met Val Asp Leu Gln 
            740                 745                 750         


Asp Ala Arg Xaa Leu Asp Gly Glu Ala Gly Ser Pro Ala Gly Pro Asp 
        755                 760                 765             


Val Leu Pro Xaa Asp Gly Gln Ala Ala Ala Ala Gln Leu Val Ala Gly 
    770                 775                 780                 


Trp Pro Ala Arg Ala Xaa Pro Val Asn Leu Ala Gly Leu Ala Xaa Val 
785                 790                 795                 800 


Arg Arg Ala Gly Gln Xaa Pro Xaa Xaa Pro Gly Xaa Ser Glu Gly Ala 
                805                 810                 815     


Pro Gly Arg Pro Gln Leu Leu Ala Pro Leu Ser Phe Gln Asn Pro Val 
            820                 825                 830         


Tyr Gln Met Ala Ala Gly Leu Pro Leu Ser Pro Arg Gly Leu Gly Asp 
        835                 840                 845             


Ser Gly Ser Glu Gly His Ser Ser Leu Ser Ser His Ser Asn Ser Glu 
    850                 855                 860                 


Glu Leu Ala Ala Ala Ala Lys Leu Gly Ser Phe Ser Xaa Ala Ala Glu 
865                 870                 875                 880 


Glu Leu Ala Arg Arg Pro Gly Glu Leu Ala Arg Arg Gln Met Ser Leu 
                885                 890                 895     


Xaa Glu Lys Gly Gly Gln Pro Xaa Val Pro Arg Gln Asn Ser Ala Gly 
            900                 905                 910         


Pro Gln Arg Arg Ile Asp Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        915                 920                 925             


Pro Ala Pro Arg Gly Arg Xaa Pro Pro Asn Leu Leu Ser Xaa Leu Gln 
    930                 935                 940                 


Tyr Pro Arg Pro Ser Ser Gly Xaa Leu Ala Ser Ala Ser Pro Asp Trp 
945                 950                 955                 960 


Val Gly Pro Ser Xaa Arg Leu Arg Gln Gln Ser Ser Ser Ser Lys Gly 
                965                 970                 975     


Asp Ser Pro Glu Leu Lys Pro Arg Ala Val His Lys Gln Gly Pro Ser 
            980                 985                 990         


Pro Val Ser Pro Asn Ala Leu Asp  Arg Xaa Ala Ala Trp  Leu Leu Xaa 
        995                 1000                 1005             


Met Asn  Ala Gln Leu Leu Glu  Asp Glu Gly Leu Gly  Pro Asp Pro 
    1010                 1015                 1020             


Pro His  Arg Asp Arg Leu Arg  Ser Lys Asp Glu Leu  Ser Gln Ala 
    1025                 1030                 1035             


Glu Lys  Asp Leu Ala Val Leu  Gln Asp Lys Leu Arg  Ile Ser Xaa 
    1040                 1045                 1050             


Lys Lys  Leu Glu Glu Tyr Glu  Xaa Leu Phe Lys Cys  Gln Glu Glu 
    1055                 1060                 1065             


Xaa Xaa  Gln Lys Leu Val Leu  Glu Tyr Gln Ala Arg  Leu Glu Glu 
    1070                 1075                 1080             


Gly Glu  Glu Arg Leu Arg Arg  Gln Gln Glu Asp Lys  Asp Ile Gln 
    1085                 1090                 1095             


Met Lys  Gly Ile Ile Ser Arg  Leu Met Ser Val Glu  Glu Glu Leu 
    1100                 1105                 1110             


Lys Lys  Asp His Ala Glu Met  Gln Ala Ala Val Asp  Ser Lys Gln 
    1115                 1120                 1125             


Lys Ile  Ile Asp Ala Gln Glu  Lys Arg Ile Ala Ser  Leu Asp Ala 
    1130                 1135                 1140             


Ala Asn  Ala Arg Leu Met Ser  Ala Leu Xaa Gln Leu  Lys Glu Arg 
    1145                 1150                 1155             


Tyr Ser  Met Gln Ala Arg Asn  Gly Ile Ser Pro Xaa  Asn Pro Xaa 
    1160                 1165                 1170             


Lys Leu  Gln Ile Xaa Glu Asn  Gly Glu Phe Arg Asn  Ser Ser Asn 
    1175                 1180                 1185             


Cys 
    


<210> 7524
<211> 1069
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (83)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (325)..(325)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (699)..(699)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (717)..(718)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (813)..(813)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (844)..(844)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (861)..(861)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (874)..(874)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (917)..(917)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (978)..(979)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1062)..(1062)
<223> Selenocysteine

<400> 7524
Ser Gln Pro Lys Leu Asp Arg Asn His Ser Phe Arg His Ile Leu Pro 
1               5                   10                  15      


Gly Phe Arg Ser Ala Ala Ala Ala Ala Ala Asp Asn Glu Arg Ser His 
            20                  25                  30          


Leu Met Pro Arg Leu Lys Glu Ser Arg Ser His Glu Ser Leu Leu Ser 
        35                  40                  45              


Pro Ser Ser Ala Val Glu Ala Leu Asp Leu Ser Met Glu Glu Glu Val 
    50                  55                  60                  


Val Ile Lys Pro Val His Ser Ser Ile Leu Gly Gln Asp Tyr Cys Phe 
65                  70                  75                  80  


Glu Val Xaa Xaa Ser Ser Gly Ser Lys Cys Phe Ser Cys Arg Ser Ala 
                85                  90                  95      


Ala Glu Arg Asp Lys Trp Met Glu Asn Leu Arg Arg Ala Val His Pro 
            100                 105                 110         


Asn Lys Asp Asn Ser Arg Arg Val Glu His Ile Leu Lys Leu Trp Val 
        115                 120                 125             


Ile Glu Ala Lys Asp Leu Pro Ala Lys Lys Lys Tyr Leu Cys Glu Leu 
    130                 135                 140                 


Cys Leu Asp Asp Val Leu Tyr Ala Arg Xaa Xaa Gly Lys Leu Lys Xaa 
145                 150                 155                 160 


Asp Asn Val Phe Trp Gly Glu His Phe Glu Phe His Asn Leu Pro Pro 
                165                 170                 175     


Leu Arg Xaa Val Xaa Val His Leu Tyr Arg Glu Xaa Asp Lys Lys Lys 
            180                 185                 190         


Lys Lys Glu Arg Asn Ser Tyr Leu Gly Leu Val Ser Leu Pro Ala Ala 
        195                 200                 205             


Ser Val Ala Gly Arg Gln Phe Val Glu Lys Trp Tyr Pro Val Val Xaa 
    210                 215                 220                 


Pro Asn Pro Lys Gly Gly Lys Gly Pro Gly Pro Met Ile Arg Ile Lys 
225                 230                 235                 240 


Ala Arg Tyr Gln Xaa Ile Xaa Ile Leu Pro Met Glu Met Tyr Lys Glu 
                245                 250                 255     


Phe Ala Glu His Ile Xaa Asn His Tyr Leu Gly Leu Cys Ala Ala Leu 
            260                 265                 270         


Glu Pro Ile Leu Ser Ala Lys Xaa Lys Glu Glu Met Ala Ser Ala Leu 
        275                 280                 285             


Val His Ile Leu Gln Ser Xaa Gly Lys Val Lys Asp Phe Leu Xaa Asp 
    290                 295                 300                 


Leu Met Met Ser Glu Val Asp Arg Cys Gly Asp Asn Glu His Leu Ile 
305                 310                 315                 320 


Phe Arg Glu Asn Xaa Leu Ala Xaa Lys Ala Ile Glu Glu Tyr Leu Lys 
                325                 330                 335     


Leu Val Gly Gln Lys Tyr Leu Gln Asp Ala Leu Gly Glu Phe Ile Lys 
            340                 345                 350         


Ala Leu Tyr Glu Ser Asp Glu Asn Cys Glu Val Asp Pro Ser Lys Cys 
        355                 360                 365             


Ser Ala Ala Asp Leu Pro Glu His Gln Gly Asn Leu Lys Met Cys Cys 
    370                 375                 380                 


Glu Leu Ala Phe Cys Lys Ile Ile Asn Ser Tyr Cys Val Phe Pro Arg 
385                 390                 395                 400 


Glu Leu Lys Glu Val Phe Ala Ser Trp Arg Gln Glu Cys Ser Ser Arg 
                405                 410                 415     


Gly Arg Pro Asp Ile Ser Glu Arg Leu Ile Ser Ala Ser Leu Phe Leu 
            420                 425                 430         


Arg Phe Leu Cys Pro Ala Ile Met Ser Pro Ser Leu Phe Asn Leu Leu 
        435                 440                 445             


Gln Glu Tyr Pro Asp Asp Arg Xaa Ala Arg Xaa Leu Xaa Leu Ile Ala 
    450                 455                 460                 


Lys Val Xaa Gln Asn Leu Ala Asn Phe Ala Lys Phe Gly Ser Lys Glu 
465                 470                 475                 480 


Glu Tyr Met Ser Phe Met Asn Gln Phe Leu Glu His Glu Trp Xaa Asn 
                485                 490                 495     


Met Gln Arg Phe Leu Leu Glu Ile Ser Asn Pro Glu Xaa Leu Ser Asn 
            500                 505                 510         


Xaa Ala Gly Phe Glu Gly Tyr Ile Asp Leu Gly Arg Glu Leu Ser Ser 
        515                 520                 525             


Leu His Ser Leu Leu Trp Glu Ala Val Ser Gln Leu Glu Gln Ser Ile 
    530                 535                 540                 


Val Ser Lys Leu Gly Pro Leu Pro Arg Ile Leu Arg Asp Val His Xaa 
545                 550                 555                 560 


Ala Leu Ser Xaa Pro Gly Ser Gly Gln Leu Pro Gly Xaa Asn Asp Leu 
                565                 570                 575     


Ala Ser Xaa Pro Gly Ser Gly Ser Ser Ser Ile Ser Ala Gly Leu Gln 
            580                 585                 590         


Lys Met Val Ile Glu Asn Asp Leu Ser Gly Leu Ile Asp Phe Xaa Arg 
        595                 600                 605             


Leu Pro Ser Pro Xaa Pro Glu Asn Lys Asp Leu Phe Phe Val Xaa Arg 
    610                 615                 620                 


Ser Ser Gly Val Gln Pro Ser Pro Ala Arg Ser Ser Ser Tyr Ser Glu 
625                 630                 635                 640 


Ala Asn Glu Pro Asp Leu Gln Met Ala Asn Gly Gly Lys Ser Leu Ser 
                645                 650                 655     


Met Val Asp Leu Gln Asp Ala Arg Xaa Leu Asp Gly Glu Ala Gly Ser 
            660                 665                 670         


Pro Ala Gly Pro Asp Val Leu Pro Xaa Asp Gly Gln Ala Ala Ala Ala 
        675                 680                 685             


Gln Leu Val Ala Gly Trp Pro Ala Arg Ala Xaa Pro Val Asn Leu Ala 
    690                 695                 700                 


Gly Leu Ala Xaa Val Arg Arg Ala Gly Gln Xaa Pro Xaa Xaa Pro Gly 
705                 710                 715                 720 


Xaa Ser Glu Gly Ala Pro Gly Arg Pro Gln Leu Leu Ala Pro Leu Ser 
                725                 730                 735     


Phe Gln Asn Pro Val Tyr Gln Met Ala Ala Gly Leu Pro Leu Ser Pro 
            740                 745                 750         


Arg Gly Leu Gly Asp Ser Gly Ser Glu Gly His Ser Ser Leu Ser Ser 
        755                 760                 765             


His Ser Asn Ser Glu Glu Leu Ala Ala Ala Ala Lys Leu Gly Ser Phe 
    770                 775                 780                 


Ser Xaa Ala Ala Glu Glu Leu Ala Arg Arg Pro Gly Glu Leu Ala Arg 
785                 790                 795                 800 


Arg Gln Met Ser Leu Xaa Glu Lys Gly Gly Gln Pro Xaa Val Pro Arg 
                805                 810                 815     


Gln Asn Ser Ala Gly Pro Gln Arg Arg Ile Asp Gln Pro Pro Pro Pro 
            820                 825                 830         


Pro Pro Pro Pro Pro Pro Ala Pro Arg Gly Arg Xaa Pro Pro Asn Leu 
        835                 840                 845             


Leu Ser Xaa Leu Gln Tyr Pro Arg Pro Ser Ser Gly Xaa Leu Ala Ser 
    850                 855                 860                 


Ala Ser Pro Asp Trp Val Gly Pro Ser Xaa Arg Leu Arg Gln Gln Ser 
865                 870                 875                 880 


Ser Ser Ser Lys Gly Asp Ser Pro Glu Leu Lys Pro Arg Ala Val His 
                885                 890                 895     


Lys Gln Gly Pro Ser Pro Val Ser Pro Asn Ala Leu Asp Arg Xaa Ala 
            900                 905                 910         


Ala Trp Leu Leu Xaa Met Asn Ala Gln Leu Leu Glu Asp Glu Gly Leu 
        915                 920                 925             


Gly Pro Asp Pro Pro His Arg Asp Arg Leu Arg Ser Lys Asp Glu Leu 
    930                 935                 940                 


Ser Gln Ala Glu Lys Asp Leu Ala Val Leu Gln Asp Lys Leu Arg Ile 
945                 950                 955                 960 


Ser Xaa Lys Lys Leu Glu Glu Tyr Glu Xaa Leu Phe Lys Cys Gln Glu 
                965                 970                 975     


Glu Xaa Xaa Gln Lys Leu Val Leu Glu Tyr Gln Ala Arg Leu Glu Glu 
            980                 985                 990         


Gly Glu Glu Arg Leu Arg Arg Gln  Gln Glu Asp Lys Asp  Ile Gln Met 
        995                 1000                 1005             


Lys Gly  Ile Ile Ser Arg Leu  Met Ser Val Glu Glu  Glu Leu Lys 
    1010                 1015                 1020             


Lys Asp  His Ala Glu Met Gln  Ala Ala Val Asp Ser  Lys Gln Lys 
    1025                 1030                 1035             


Ile Ile  Asp Ala Gln Glu Lys  Arg Ile Ala Ser Leu  Asp Ala Ala 
    1040                 1045                 1050             


Asn Ala  Arg Leu Met Ser Ala  Leu Xaa Gln Leu Lys  Glu Ser Met 
    1055                 1060                 1065             


His 
    


<210> 7525
<211> 504
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (394)..(394)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(501)
<223> Selenocysteine

<400> 7525
Met Ala Val Pro Ala Ala Leu Ile Pro Pro Xaa Gln Leu Val Pro Pro 
1               5                   10                  15      


Gln Pro Pro Ile Ser Xaa Ser Ala Ser Ser Ser Gly Xaa Xaa Xaa Ser 
            20                  25                  30          


Xaa Ser Ser Ala Xaa Ser Ser Pro Ala Pro Ser Ile Gly Pro Pro Ala 
        35                  40                  45              


Ser Ser Gly Pro Xaa Leu Phe Arg Pro Glu Pro Ile Ala Ser Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Xaa Val Xaa Ser Xaa Gly Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Gly Gly Gly Gly Gly Ser Ser Gly Asn Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Gly Gly Gly Gly Ser Asn Cys Asn Pro Asn Leu Ala Ala Ala Ser 
            100                 105                 110         


Asn Gly Ser Gly Gly Gly Gly Gly Gly Ile Ser Ala Gly Gly Gly Val 
        115                 120                 125             


Ala Ser Ser Xaa Pro Ile Asn Ala Ser Xaa Gly Ser Ser Ser Ser Ser 
    130                 135                 140                 


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Ser Ser Ser Cys Gly Pro Leu Pro Gly Lys Pro Val Tyr Ser Xaa Pro 
                165                 170                 175     


Ser Pro Val Glu Asn Xaa Pro Gln Asn Asn Glu Cys Lys Met Val Asp 
            180                 185                 190         


Leu Arg Gly Ala Lys Val Ala Ser Phe Xaa Val Glu Gly Cys Glu Leu 
        195                 200                 205             


Ile Cys Leu Pro Gln Ala Phe Asp Leu Phe Leu Lys His Leu Val Gly 
    210                 215                 220                 


Gly Leu His Xaa Val Tyr Xaa Lys Leu Lys Arg Leu Glu Ile Xaa Pro 
225                 230                 235                 240 


Val Val Cys Asn Val Glu Gln Val Arg Ile Leu Arg Gly Leu Gly Ala 
                245                 250                 255     


Ile Gln Pro Gly Val Asn Arg Cys Lys Leu Ile Ser Arg Lys Asp Phe 
            260                 265                 270         


Glu Xaa Leu Tyr Asn Asp Cys Xaa Asn Ala Ser Ser Arg Pro Gly Arg 
        275                 280                 285             


Pro Pro Lys Arg Xaa Gln Ser Val Xaa Ser Pro Glu Asn Ser His Ile 
    290                 295                 300                 


Met Pro His Ser Val Pro Gly Leu Met Ser Pro Gly Ile Ile Pro Pro 
305                 310                 315                 320 


Xaa Asp Glu Xaa Pro Leu Ser Xaa Pro Xaa Ala Arg Asp Ser Leu Asp 
                325                 330                 335     


Lys Leu Ser Leu Xaa Gly His Gly Gln Pro Leu Pro Pro Gly Phe Pro 
            340                 345                 350         


Ser Pro Phe Leu Phe Pro Asp Gly Leu Ser Ser Ile Glu Xaa Leu Leu 
        355                 360                 365             


Xaa Asn Ile Gln Gly Leu Leu Lys Val Ala Ile Asp Asn Ala Arg Ala 
    370                 375                 380                 


Gln Glu Lys Gln Val Gln Leu Glu Lys Xaa Glu Leu Lys Met Asp Phe 
385                 390                 395                 400 


Leu Arg Glu Arg Glu Leu Arg Glu Xaa Leu Glu Lys Gln Leu Ala Met 
                405                 410                 415     


Glu Gln Lys Asn Arg Ala Ile Val Gln Lys Arg Leu Lys Lys Glu Lys 
            420                 425                 430         


Lys Ala Lys Arg Lys Leu Gln Glu Ala Leu Glu Phe Glu Xaa Lys Arg 
        435                 440                 445             


Arg Glu Gln Ala Glu Gln Xaa Leu Lys Gln Ala Ala Ser Xaa Asp Ser 
    450                 455                 460                 


Leu Arg Val Leu Asn Asp Ser Leu Xaa Pro Glu Ile Glu Ala Asp Arg 
465                 470                 475                 480 


Ser Gly Gly Arg Xaa Asp Ala Glu Arg Xaa Ile Gln Asp Gly Arg Leu 
                485                 490                 495     


Tyr Leu Lys Xaa Xaa Val Met Tyr 
            500                 


<210> 7526
<211> 558
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (448)..(448)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (539)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (544)..(544)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(555)
<223> Selenocysteine

<400> 7526
Met Ala Val Pro Ala Ala Leu Ile Pro Pro Xaa Gln Leu Val Pro Pro 
1               5                   10                  15      


Gln Pro Pro Ile Ser Xaa Ser Ala Ser Ser Ser Gly Xaa Xaa Xaa Ser 
            20                  25                  30          


Xaa Ser Ser Ala Xaa Ser Ser Pro Ala Pro Ser Ile Gly Pro Pro Ala 
        35                  40                  45              


Ser Ser Gly Pro Xaa Leu Phe Arg Pro Glu Pro Ile Ala Ser Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Xaa Val Xaa Ser Xaa Gly Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Gly Gly Gly Gly Gly Ser Ser Gly Asn Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Gly Gly Gly Gly Ser Asn Cys Asn Pro Asn Leu Ala Ala Ala Ser 
            100                 105                 110         


Asn Gly Ser Gly Gly Gly Gly Gly Gly Ile Ser Ala Gly Gly Gly Val 
        115                 120                 125             


Ala Ser Ser Xaa Pro Ile Asn Ala Ser Xaa Gly Ser Ser Ser Ser Ser 
    130                 135                 140                 


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Ser Ser Ser Cys Gly Pro Leu Pro Gly Lys Pro Val Tyr Ser Xaa Pro 
                165                 170                 175     


Ser Pro Val Glu Asn Xaa Pro Gln Asn Asn Glu Cys Lys Met Val Asp 
            180                 185                 190         


Leu Arg Gly Ala Lys Val Ala Ser Phe Xaa Val Glu Gly Cys Glu Leu 
        195                 200                 205             


Ile Cys Leu Pro Gln Ala Phe Asp Leu Phe Leu Lys His Leu Val Gly 
    210                 215                 220                 


Gly Leu His Xaa Val Tyr Xaa Lys Leu Lys Arg Leu Glu Ile Xaa Pro 
225                 230                 235                 240 


Val Val Cys Asn Val Glu Gln Val Arg Ile Leu Arg Gly Leu Gly Ala 
                245                 250                 255     


Ile Gln Pro Gly Val Asn Arg Cys Lys Leu Ile Ser Arg Lys Asp Phe 
            260                 265                 270         


Glu Xaa Leu Tyr Asn Asp Cys Xaa Asn Ala Ser Ser Arg Pro Gly Arg 
        275                 280                 285             


Pro Pro Lys Arg Xaa Gln Ser Val Xaa Ser Pro Glu Asn Ser His Ile 
    290                 295                 300                 


Met Pro His Ser Val Pro Gly Leu Met Ser Pro Gly Ile Ile Pro Pro 
305                 310                 315                 320 


Xaa Gly Leu Xaa Ala Ala Ala Ala Ala Ala Ala Ala Ala Xaa Asn Ala 
                325                 330                 335     


Ala Ile Ala Glu Ala Met Lys Val Lys Lys Ile Lys Leu Glu Ala Met 
            340                 345                 350         


Ser Asn Tyr His Ala Ser Asn Asn Gln His Gly Ala Asp Ser Glu Asn 
        355                 360                 365             


Gly Asp Met Asn Ser Ser Val Asp Glu Xaa Pro Leu Ser Xaa Pro Xaa 
    370                 375                 380                 


Ala Arg Asp Ser Leu Asp Lys Leu Ser Leu Xaa Gly His Gly Gln Pro 
385                 390                 395                 400 


Leu Pro Pro Gly Phe Pro Ser Pro Phe Leu Phe Pro Asp Gly Leu Ser 
                405                 410                 415     


Ser Ile Glu Xaa Leu Leu Xaa Asn Ile Gln Gly Leu Leu Lys Val Ala 
            420                 425                 430         


Ile Asp Asn Ala Arg Ala Gln Glu Lys Gln Val Gln Leu Glu Lys Xaa 
        435                 440                 445             


Glu Leu Lys Met Asp Phe Leu Arg Glu Arg Glu Leu Arg Glu Xaa Leu 
    450                 455                 460                 


Glu Lys Gln Leu Ala Met Glu Gln Lys Asn Arg Ala Ile Val Gln Lys 
465                 470                 475                 480 


Arg Leu Lys Lys Glu Lys Lys Ala Lys Arg Lys Leu Gln Glu Ala Leu 
                485                 490                 495     


Glu Phe Glu Xaa Lys Arg Arg Glu Gln Ala Glu Gln Xaa Leu Lys Gln 
            500                 505                 510         


Ala Ala Ser Xaa Asp Ser Leu Arg Val Leu Asn Asp Ser Leu Xaa Pro 
        515                 520                 525             


Glu Ile Glu Ala Asp Arg Ser Gly Gly Arg Xaa Asp Ala Glu Arg Xaa 
    530                 535                 540                 


Ile Gln Asp Gly Arg Leu Tyr Leu Lys Xaa Xaa Val Met Tyr 
545                 550                 555             


<210> 7527
<211> 706
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (532)..(532)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (543)..(543)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (571)..(571)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (675)..(675)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (687)..(687)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (692)..(692)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (702)..(703)
<223> Selenocysteine

<400> 7527
Met Ala Val Pro Ala Ala Leu Ile Pro Pro Xaa Gln Leu Val Pro Pro 
1               5                   10                  15      


Gln Pro Pro Ile Ser Xaa Ser Ala Ser Ser Ser Gly Xaa Xaa Xaa Ser 
            20                  25                  30          


Xaa Ser Ser Ala Xaa Ser Ser Pro Ala Pro Ser Ile Gly Pro Pro Ala 
        35                  40                  45              


Ser Ser Gly Pro Xaa Leu Phe Arg Pro Glu Pro Ile Ala Ser Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Xaa Val Xaa Ser Xaa Gly Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Gly Gly Gly Gly Gly Ser Ser Gly Asn Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Gly Gly Gly Gly Ser Asn Cys Asn Pro Asn Leu Ala Ala Ala Ser 
            100                 105                 110         


Asn Gly Ser Gly Gly Gly Gly Gly Gly Ile Ser Ala Gly Gly Gly Val 
        115                 120                 125             


Ala Ser Ser Xaa Pro Ile Asn Ala Ser Xaa Gly Ser Ser Ser Ser Ser 
    130                 135                 140                 


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Ser Ser Ser Cys Gly Pro Leu Pro Gly Lys Pro Val Tyr Ser Xaa Pro 
                165                 170                 175     


Ser Pro Val Glu Asn Xaa Pro Gln Asn Asn Glu Cys Lys Met Val Asp 
            180                 185                 190         


Leu Arg Gly Ala Lys Val Ala Ser Phe Xaa Val Glu Gly Cys Glu Leu 
        195                 200                 205             


Ile Cys Leu Pro Gln Ala Phe Asp Leu Phe Leu Lys His Leu Val Gly 
    210                 215                 220                 


Gly Leu His Xaa Val Tyr Xaa Lys Leu Lys Arg Leu Glu Ile Xaa Pro 
225                 230                 235                 240 


Val Val Cys Asn Val Glu Gln Val Arg Ile Leu Arg Gly Leu Gly Ala 
                245                 250                 255     


Ile Gln Pro Gly Val Asn Arg Cys Lys Leu Ile Ser Arg Lys Asp Phe 
            260                 265                 270         


Glu Xaa Leu Tyr Asn Asp Cys Xaa Asn Ala Ser Ser Arg Pro Gly Arg 
        275                 280                 285             


Pro Pro Lys Arg Xaa Gln Ser Val Xaa Ser Pro Glu Asn Ser His Ile 
    290                 295                 300                 


Met Pro His Ser Val Pro Gly Leu Met Ser Pro Gly Ile Ile Pro Pro 
305                 310                 315                 320 


Xaa Gly Leu Xaa Ala Ala Ala Ala Ala Ala Ala Ala Ala Xaa Asn Ala 
                325                 330                 335     


Ala Ile Ala Glu Ala Met Lys Val Lys Lys Ile Lys Leu Glu Ala Met 
            340                 345                 350         


Ser Asn Tyr His Ala Ser Asn Asn Gln His Gly Ala Asp Ser Glu Asn 
        355                 360                 365             


Gly Asp Met Asn Ser Ser Val Gly Leu Glu Leu Pro Phe Met Met Met 
    370                 375                 380                 


Pro His Pro Leu Ile Pro Val Ser Leu Pro Pro Ala Ser Val Xaa Met 
385                 390                 395                 400 


Ala Met Ser Gln Met Asn His Leu Ser Xaa Ile Ala Asn Met Ala Ala 
                405                 410                 415     


Ala Ala Gln Val Gln Ser Pro Pro Ser Arg Val Glu Xaa Ser Val Ile 
            420                 425                 430         


Lys Glu Arg Val Pro Asp Ser Pro Ser Pro Ala Pro Ser Leu Glu Glu 
        435                 440                 445             


Gly Arg Arg Pro Gly Ser His Pro Ser Ser His Arg Ser Ser Ser Val 
    450                 455                 460                 


Ser Ser Ser Pro Ala Arg Xaa Glu Ser Ser Ser Asp Arg Ile Pro Val 
465                 470                 475                 480 


His Gln Asn Gly Leu Ser Met Asn Gln Met Leu Met Gly Leu Ser Pro 
                485                 490                 495     


Asn Val Leu Pro Gly Pro Lys Glu Gly Asp Leu Ala Gly His Asp Met 
            500                 505                 510         


Gly His Glu Ser Lys Arg Met His Ile Glu Lys Asp Glu Xaa Pro Leu 
        515                 520                 525             


Ser Xaa Pro Xaa Ala Arg Asp Ser Leu Asp Lys Leu Ser Leu Xaa Gly 
    530                 535                 540                 


His Gly Gln Pro Leu Pro Pro Gly Phe Pro Ser Pro Phe Leu Phe Pro 
545                 550                 555                 560 


Asp Gly Leu Ser Ser Ile Glu Xaa Leu Leu Xaa Asn Ile Gln Gly Leu 
                565                 570                 575     


Leu Lys Val Ala Ile Asp Asn Ala Arg Ala Gln Glu Lys Gln Val Gln 
            580                 585                 590         


Leu Glu Lys Xaa Glu Leu Lys Met Asp Phe Leu Arg Glu Arg Glu Leu 
        595                 600                 605             


Arg Glu Xaa Leu Glu Lys Gln Leu Ala Met Glu Gln Lys Asn Arg Ala 
    610                 615                 620                 


Ile Val Gln Lys Arg Leu Lys Lys Glu Lys Lys Ala Lys Arg Lys Leu 
625                 630                 635                 640 


Gln Glu Ala Leu Glu Phe Glu Xaa Lys Arg Arg Glu Gln Ala Glu Gln 
                645                 650                 655     


Xaa Leu Lys Gln Ala Ala Ser Xaa Asp Ser Leu Arg Val Leu Asn Asp 
            660                 665                 670         


Ser Leu Xaa Pro Glu Ile Glu Ala Asp Arg Ser Gly Gly Arg Xaa Asp 
        675                 680                 685             


Ala Glu Arg Xaa Ile Gln Asp Gly Arg Leu Tyr Leu Lys Xaa Xaa Val 
    690                 695                 700                 


Met Tyr 
705     


<210> 7528
<211> 758
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (582)..(582)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (623)..(623)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (739)..(739)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (754)..(755)
<223> Selenocysteine

<400> 7528
Met Ala Val Pro Ala Ala Leu Ile Pro Pro Xaa Gln Leu Val Pro Pro 
1               5                   10                  15      


Gln Pro Pro Ile Ser Xaa Ser Ala Ser Ser Ser Gly Xaa Xaa Xaa Ser 
            20                  25                  30          


Xaa Ser Ser Ala Xaa Ser Ser Pro Ala Pro Ser Ile Gly Pro Pro Ala 
        35                  40                  45              


Ser Ser Gly Pro Xaa Leu Phe Arg Pro Glu Pro Ile Ala Ser Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Xaa Val Xaa Ser Xaa Gly Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Gly Gly Gly Gly Gly Ser Ser Gly Asn Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Gly Gly Gly Gly Ser Asn Cys Asn Pro Asn Leu Ala Ala Ala Ser 
            100                 105                 110         


Asn Gly Ser Gly Gly Gly Gly Gly Gly Ile Ser Ala Gly Gly Gly Val 
        115                 120                 125             


Ala Ser Ser Xaa Pro Ile Asn Ala Ser Xaa Gly Ser Ser Ser Ser Ser 
    130                 135                 140                 


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Ser Ser Ser Cys Gly Pro Leu Pro Gly Lys Pro Val Tyr Ser Xaa Pro 
                165                 170                 175     


Ser Pro Val Glu Asn Xaa Pro Gln Asn Asn Glu Cys Lys Met Val Asp 
            180                 185                 190         


Leu Arg Gly Ala Lys Val Ala Ser Phe Xaa Val Glu Gly Cys Glu Leu 
        195                 200                 205             


Ile Cys Leu Pro Gln Ala Phe Asp Leu Phe Leu Lys His Leu Val Gly 
    210                 215                 220                 


Gly Leu His Xaa Val Tyr Xaa Lys Leu Lys Arg Leu Glu Ile Xaa Pro 
225                 230                 235                 240 


Val Val Cys Asn Val Glu Gln Val Arg Ile Leu Arg Gly Leu Gly Ala 
                245                 250                 255     


Ile Gln Pro Gly Val Asn Arg Cys Lys Leu Ile Ser Arg Lys Asp Phe 
            260                 265                 270         


Glu Xaa Leu Tyr Asn Asp Cys Xaa Asn Ala Ser Ser Arg Pro Gly Arg 
        275                 280                 285             


Pro Pro Lys Arg Xaa Gln Ser Val Xaa Ser Pro Glu Asn Ser His Ile 
    290                 295                 300                 


Met Pro His Ser Val Pro Gly Leu Met Ser Pro Gly Ile Ile Pro Pro 
305                 310                 315                 320 


Xaa Gly Leu Xaa Ala Ala Ala Ala Ala Ala Ala Ala Ala Xaa Asn Ala 
                325                 330                 335     


Ala Ile Ala Glu Ala Met Lys Val Lys Lys Ile Lys Leu Glu Ala Met 
            340                 345                 350         


Ser Asn Tyr His Ala Ser Asn Asn Gln His Gly Ala Asp Ser Glu Asn 
        355                 360                 365             


Gly Asp Met Asn Ser Ser Val Gly Ser Ser Asp Gly Ser Trp Asp Lys 
    370                 375                 380                 


Glu Xaa Leu Pro Ser Ser Pro Ser Gln Gly Pro Gln Ala Ser Ile Xaa 
385                 390                 395                 400 


His Pro Arg Met Pro Gly Ala Arg Ser Leu Pro Leu Ser His Pro Leu 
                405                 410                 415     


Asn His Leu Gln Gln Ser His Leu Leu Pro Asn Gly Leu Glu Leu Pro 
            420                 425                 430         


Phe Met Met Met Pro His Pro Leu Ile Pro Val Ser Leu Pro Pro Ala 
        435                 440                 445             


Ser Val Xaa Met Ala Met Ser Gln Met Asn His Leu Ser Xaa Ile Ala 
    450                 455                 460                 


Asn Met Ala Ala Ala Ala Gln Val Gln Ser Pro Pro Ser Arg Val Glu 
465                 470                 475                 480 


Xaa Ser Val Ile Lys Glu Arg Val Pro Asp Ser Pro Ser Pro Ala Pro 
                485                 490                 495     


Ser Leu Glu Glu Gly Arg Arg Pro Gly Ser His Pro Ser Ser His Arg 
            500                 505                 510         


Ser Ser Ser Val Ser Ser Ser Pro Ala Arg Xaa Glu Ser Ser Ser Asp 
        515                 520                 525             


Arg Ile Pro Val His Gln Asn Gly Leu Ser Met Asn Gln Met Leu Met 
    530                 535                 540                 


Gly Leu Ser Pro Asn Val Leu Pro Gly Pro Lys Glu Gly Asp Leu Ala 
545                 550                 555                 560 


Gly His Asp Met Gly His Glu Ser Lys Arg Met His Ile Glu Lys Asp 
                565                 570                 575     


Glu Xaa Pro Leu Ser Xaa Pro Xaa Ala Arg Asp Ser Leu Asp Lys Leu 
            580                 585                 590         


Ser Leu Xaa Gly His Gly Gln Pro Leu Pro Pro Gly Phe Pro Ser Pro 
        595                 600                 605             


Phe Leu Phe Pro Asp Gly Leu Ser Ser Ile Glu Xaa Leu Leu Xaa Asn 
    610                 615                 620                 


Ile Gln Gly Leu Leu Lys Val Ala Ile Asp Asn Ala Arg Ala Gln Glu 
625                 630                 635                 640 


Lys Gln Val Gln Leu Glu Lys Xaa Glu Leu Lys Met Asp Phe Leu Arg 
                645                 650                 655     


Glu Arg Glu Leu Arg Glu Xaa Leu Glu Lys Gln Leu Ala Met Glu Gln 
            660                 665                 670         


Lys Asn Arg Ala Ile Val Gln Lys Arg Leu Lys Lys Glu Lys Lys Ala 
        675                 680                 685             


Lys Arg Lys Leu Gln Glu Ala Leu Glu Phe Glu Xaa Lys Arg Arg Glu 
    690                 695                 700                 


Gln Ala Glu Gln Xaa Leu Lys Gln Ala Ala Ser Xaa Asp Ser Leu Arg 
705                 710                 715                 720 


Val Leu Asn Asp Ser Leu Xaa Pro Glu Ile Glu Ala Asp Arg Ser Gly 
                725                 730                 735     


Gly Arg Xaa Asp Ala Glu Arg Xaa Ile Gln Asp Gly Arg Leu Tyr Leu 
            740                 745                 750         


Lys Xaa Xaa Val Met Tyr 
        755             


<210> 7529
<211> 249
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<400> 7529
Ile Ala Asn Met Ala Ala Ala Ala Gln Ile His Ser Pro Leu Ser Arg 
1               5                   10                  15      


Ala Gly Xaa Ser Val Ile Lys Glu Arg Ile Pro Glu Ser Pro Ser Pro 
            20                  25                  30          


Ala Pro Ser Leu Glu Glu Asn His Arg Pro Gly Ser Gln Xaa Ser Ser 
        35                  40                  45              


His Xaa Ser Ser Ser Val Ser Ser Ser Pro Ser Gln Met Asp His His 
    50                  55                  60                  


Leu Glu Arg Met Glu Glu Val Pro Val Gln Ile Pro Ile Met Lys Ser 
65                  70                  75                  80  


Pro Leu Asp Lys Ile Gln Leu Xaa Pro Gly Gln Ala Leu Pro Ala Gly 
                85                  90                  95      


Phe Pro Gly Pro Phe Ile Phe Ala Asp Ser Leu Ser Ser Val Glu Xaa 
            100                 105                 110         


Leu Leu Xaa Asn Ile Gln Val Asn Asn Ile Ser Ile Asn Lys Ile Asn 
        115                 120                 125             


Gly Leu Leu Lys Val Ala Leu Asp Asn Ala Arg Ile Gln Glu Lys Gln 
    130                 135                 140                 


Ile Gln Gln Glu Lys Lys Glu Leu Arg Leu Glu Leu Tyr Arg Glu Arg 
145                 150                 155                 160 


Glu Ile Arg Glu Asn Leu Glu Arg Gln Leu Ala Val Glu Leu Gln Ser 
                165                 170                 175     


Arg Xaa Xaa Met Gln Lys Arg Leu Lys Lys Glu Lys Lys Xaa Lys Arg 
            180                 185                 190         


Lys Leu Gln Glu Ala Leu Glu Phe Glu Ser Lys Arg Arg Glu Gln Val 
        195                 200                 205             


Glu Gln Ala Leu Lys Gln Ala Xaa Xaa Ser Asp Ser Gly Leu Arg Met 
    210                 215                 220                 


Leu Lys Asp Xaa Gly Ile Pro Asp Ile Glu Ile Glu Asn Asn Gly Xaa 
225                 230                 235                 240 


Pro His Asp Ser Ala Ala Met Gln Ala 
                245                 


<210> 7530
<211> 380
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (356)..(356)
<223> Selenocysteine

<400> 7530
Met Ala Glu Ala Met Lys Leu Gln Lys Met Lys Leu Met Ala Met Asn 
1               5                   10                  15      


Xaa Leu Gln Gly Asn Gly Ser Gln Asn Gly Xaa Glu Ser Glu Pro Asp 
            20                  25                  30          


Asp Leu Asn Ser Asn Xaa Gly Gly Ser Glu Ser Ser Trp Asp Lys Asp 
        35                  40                  45              


Lys Met Gln Ser Pro Phe Ala Ala Pro Gly Pro Gln His Gly Ile Ala 
    50                  55                  60                  


His Ala Ala Leu Ala Gly Gln Pro Gly Ile Gly Gly Ala Pro Xaa Leu 
65                  70                  75                  80  


Asn Pro Leu Gln Gln Asn His Leu Leu Xaa Asn Arg Leu Asp Leu Pro 
                85                  90                  95      


Phe Met Met Met Pro His Pro Leu Leu Pro Val Ser Leu Pro Pro Ala 
            100                 105                 110         


Ser Val Ala Met Ala Met Asn Gln Met Asn His Leu Asn Xaa Ile Ala 
        115                 120                 125             


Asn Met Ala Ala Ala Ala Gln Ile His Ser Pro Leu Ser Arg Ala Gly 
    130                 135                 140                 


Xaa Ser Val Ile Lys Glu Arg Ile Pro Glu Ser Pro Ser Pro Ala Pro 
145                 150                 155                 160 


Ser Leu Glu Glu Asn His Arg Pro Gly Ser Gln Xaa Ser Ser His Xaa 
                165                 170                 175     


Ser Ser Ser Val Ser Ser Ser Pro Ser Gln Met Asp His His Leu Glu 
            180                 185                 190         


Arg Met Glu Glu Val Pro Val Gln Ile Pro Ile Met Lys Ser Pro Leu 
        195                 200                 205             


Asp Lys Ile Gln Leu Xaa Pro Gly Gln Ala Leu Pro Ala Gly Phe Pro 
    210                 215                 220                 


Gly Pro Phe Ile Phe Ala Asp Ser Leu Ser Ser Val Glu Xaa Leu Leu 
225                 230                 235                 240 


Xaa Asn Ile Gln Gly Leu Leu Lys Val Ala Leu Asp Asn Ala Arg Ile 
                245                 250                 255     


Gln Glu Lys Gln Ile Gln Gln Glu Lys Lys Glu Leu Arg Leu Glu Leu 
            260                 265                 270         


Tyr Arg Glu Arg Glu Ile Arg Glu Asn Leu Glu Arg Gln Leu Ala Val 
        275                 280                 285             


Glu Leu Gln Ser Arg Xaa Xaa Met Gln Lys Arg Leu Lys Lys Glu Lys 
    290                 295                 300                 


Lys Xaa Lys Arg Lys Leu Gln Glu Ala Leu Glu Phe Glu Ser Lys Arg 
305                 310                 315                 320 


Arg Glu Gln Val Glu Gln Ala Leu Lys Gln Ala Xaa Xaa Ser Asp Ser 
                325                 330                 335     


Gly Leu Arg Met Leu Lys Asp Xaa Gly Ile Pro Asp Ile Glu Ile Glu 
            340                 345                 350         


Asn Asn Gly Xaa Pro His Asp Ser Ala Ala Met Gln Gly Gly Asn Tyr 
        355                 360                 365             


Tyr Cys Leu Glu Met Ala Gln Gln Leu Tyr Ser Ala 
    370                 375                 380 


<210> 7531
<211> 440
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (432)..(432)
<223> Selenocysteine

<400> 7531
Met Ala Val Ser Ala Ser Pro Val Ile Ser Ala Xaa Ser Ser Gly Ala 
1               5                   10                  15      


Gly Val Pro Gly Gly Leu Phe Arg Ala Glu Pro Leu Tyr Ser Xaa Pro 
            20                  25                  30          


Arg Glu Pro Pro Arg Leu Xaa Pro Asn Met Ile Asn Ser Phe Val Val 
        35                  40                  45              


Asn Asn His Ser Asn Ser Ala Gly Gly Gly Gly Arg Gly Asn Xaa Asn 
    50                  55                  60                  


Xaa Asn Glu Cys Arg Met Val Asp Met His Gly Met Lys Val Ala Ser 
65                  70                  75                  80  


Phe Leu Met Asp Gly Gln Glu Leu Ile Cys Leu Pro Gln Val Phe Asp 
                85                  90                  95      


Leu Phe Leu Lys His Leu Val Gly Gly Leu His Xaa Val Tyr Xaa Lys 
            100                 105                 110         


Leu Lys Arg Leu Asp Ile Ser Pro Val Val Cys Xaa Val Glu Gln Val 
        115                 120                 125             


Arg Ile Leu Arg Gly Leu Gly Ala Ile Gln Pro Gly Val Asn Arg Cys 
    130                 135                 140                 


Lys Leu Ile Xaa Arg Lys Asp Phe Glu Xaa Leu Phe Xaa Asp Cys Xaa 
145                 150                 155                 160 


Asn Ala Arg Arg Lys Arg Gln Met Xaa Arg Lys Gln Ala Val Asn Ser 
                165                 170                 175     


Ser Arg Pro Gly Arg Pro Pro Lys Arg Ser Leu Gly Val Leu Gln Glu 
            180                 185                 190         


Asn Ala Arg Leu Leu Xaa His Ala Val Pro Gly Leu Leu Ser Pro Gly 
        195                 200                 205             


Leu Ile Xaa Pro Xaa Gly Ile Xaa Ala Ala Ala Met Ala Glu Ala Met 
    210                 215                 220                 


Lys Leu Gln Lys Met Lys Leu Met Ala Met Asn Xaa Leu Gln Gly Asn 
225                 230                 235                 240 


Gly Ser Gln Asn Gly Xaa Glu Ser Glu Pro Asp Asp Leu Asn Ser Asn 
                245                 250                 255     


Xaa Gly Gly Ser Glu Ser Ser Trp Asp Lys Asp Lys Met Gln Ser Pro 
            260                 265                 270         


Phe Ala Ala Pro Gly Pro Gln His Gly Ile Ala His Ala Ala Leu Ala 
        275                 280                 285             


Gly Gln Pro Gly Ile Gly Gly Ala Pro Xaa Leu Asn Pro Leu Gln Gln 
    290                 295                 300                 


Asn His Leu Leu Xaa Asn Arg Leu Asp Leu Pro Phe Met Met Met Pro 
305                 310                 315                 320 


His Pro Leu Leu Pro Val Ser Leu Pro Pro Ala Ser Val Ala Met Ala 
                325                 330                 335     


Met Asn Gln Met Asn His Leu Asn Xaa Ile Ala Asn Met Ala Ala Ala 
            340                 345                 350         


Ala Gln Ile His Ser Pro Leu Ser Arg Ala Gly Xaa Ser Val Ile Lys 
        355                 360                 365             


Glu Arg Ile Pro Glu Ser Pro Ser Pro Ala Pro Ser Leu Glu Glu Asn 
    370                 375                 380                 


His Arg Pro Gly Ser Gln Xaa Ser Ser His Xaa Ser Ser Ser Val Ser 
385                 390                 395                 400 


Ser Ser Pro Ser Gln Met Asp His His Leu Glu Arg Met Val Met Met 
                405                 410                 415     


Pro Asn Asn Arg Glu Glu Leu Ile Val Asp Gln Asp Asn Gly Leu Xaa 
            420                 425                 430         


Ile Lys Lys Phe Gln Lys Asp Asn 
        435                 440 


<210> 7532
<211> 599
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(246)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (433)..(433)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (551)..(552)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(575)
<223> Selenocysteine

<400> 7532
Met Ala Val Ser Ala Ser Pro Val Ile Ser Ala Xaa Ser Ser Gly Ala 
1               5                   10                  15      


Gly Val Pro Gly Gly Leu Phe Arg Ala Glu Pro Leu Tyr Ser Xaa Pro 
            20                  25                  30          


Arg Glu Pro Pro Arg Leu Xaa Pro Asn Met Ile Asn Ser Phe Val Val 
        35                  40                  45              


Asn Asn His Ser Asn Ser Ala Gly Gly Gly Gly Arg Gly Asn Xaa Asn 
    50                  55                  60                  


Xaa Asn Glu Cys Arg Met Val Asp Met His Gly Met Lys Val Ala Ser 
65                  70                  75                  80  


Phe Leu Met Asp Gly Gln Glu Leu Ile Cys Leu Pro Gln Val Phe Asp 
                85                  90                  95      


Leu Phe Leu Lys His Leu Val Gly Gly Leu His Xaa Val Tyr Xaa Lys 
            100                 105                 110         


Leu Lys Arg Leu Asp Ile Ser Pro Val Val Cys Xaa Val Glu Gln Val 
        115                 120                 125             


Arg Ile Leu Arg Gly Leu Gly Ala Ile Gln Pro Gly Val Asn Arg Cys 
    130                 135                 140                 


Lys Leu Ile Xaa Arg Lys Asp Phe Glu Xaa Leu Phe Xaa Asp Cys Xaa 
145                 150                 155                 160 


Asn Ala Arg Arg Lys Arg Gln Met Xaa Arg Lys Gln Ala Val Asn Ser 
                165                 170                 175     


Ser Arg Pro Gly Arg Pro Pro Lys Arg Ser Leu Gly Val Leu Gln Glu 
            180                 185                 190         


Asn Ala Arg Leu Leu Xaa His Ala Val Pro Gly Leu Leu Ser Pro Gly 
        195                 200                 205             


Leu Ile Xaa Pro Xaa Gly Ile Xaa Ala Ala Ala Met Ala Glu Ala Met 
    210                 215                 220                 


Lys Leu Gln Lys Met Lys Leu Met Ala Met Asn Xaa Leu Gln Gly Asn 
225                 230                 235                 240 


Gly Ser Gln Asn Gly Xaa Glu Ser Glu Pro Asp Asp Leu Asn Ser Asn 
                245                 250                 255     


Xaa Gly Gly Ser Glu Ser Ser Trp Asp Lys Asp Lys Met Gln Ser Pro 
            260                 265                 270         


Phe Ala Ala Pro Gly Pro Gln His Gly Ile Ala His Ala Ala Leu Ala 
        275                 280                 285             


Gly Gln Pro Gly Ile Gly Gly Ala Pro Xaa Leu Asn Pro Leu Gln Gln 
    290                 295                 300                 


Asn His Leu Leu Xaa Asn Arg Leu Asp Leu Pro Phe Met Met Met Pro 
305                 310                 315                 320 


His Pro Leu Leu Pro Val Ser Leu Pro Pro Ala Ser Val Ala Met Ala 
                325                 330                 335     


Met Asn Gln Met Asn His Leu Asn Xaa Ile Ala Asn Met Ala Ala Ala 
            340                 345                 350         


Ala Gln Ile His Ser Pro Leu Ser Arg Ala Gly Xaa Ser Val Ile Lys 
        355                 360                 365             


Glu Arg Ile Pro Glu Ser Pro Ser Pro Ala Pro Ser Leu Glu Glu Asn 
    370                 375                 380                 


His Arg Pro Gly Ser Gln Xaa Ser Ser His Xaa Ser Ser Ser Val Ser 
385                 390                 395                 400 


Ser Ser Pro Ser Gln Met Asp His His Leu Glu Arg Met Glu Glu Val 
                405                 410                 415     


Pro Val Gln Ile Pro Ile Met Lys Ser Pro Leu Asp Lys Ile Gln Leu 
            420                 425                 430         


Xaa Pro Gly Gln Ala Leu Pro Ala Gly Phe Pro Gly Pro Phe Ile Phe 
        435                 440                 445             


Ala Asp Ser Leu Ser Ser Val Glu Xaa Leu Leu Xaa Asn Ile Gln Gly 
    450                 455                 460                 


Leu Leu Lys Val Ala Leu Asp Asn Ala Arg Ile Gln Glu Lys Gln Ile 
465                 470                 475                 480 


Gln Gln Glu Lys Lys Glu Leu Arg Leu Glu Leu Tyr Arg Glu Arg Glu 
                485                 490                 495     


Ile Arg Glu Asn Leu Glu Arg Gln Leu Ala Val Glu Leu Gln Ser Arg 
            500                 505                 510         


Xaa Xaa Met Gln Lys Arg Leu Lys Lys Glu Lys Lys Xaa Lys Arg Lys 
        515                 520                 525             


Leu Gln Glu Ala Leu Glu Phe Glu Ser Lys Arg Arg Glu Gln Val Glu 
    530                 535                 540                 


Gln Ala Leu Lys Gln Ala Xaa Xaa Ser Asp Ser Gly Leu Arg Met Leu 
545                 550                 555                 560 


Lys Asp Xaa Gly Ile Pro Asp Ile Glu Ile Glu Asn Asn Gly Xaa Pro 
                565                 570                 575     


His Asp Ser Ala Ala Met Gln Gly Gly Asn Tyr Tyr Cys Leu Glu Met 
            580                 585                 590         


Ala Gln Gln Leu Tyr Ser Ala 
        595                 


<210> 7533
<211> 175
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<400> 7533
Met Ala Val Ser Ala Ser Pro Val Ile Ser Ala Xaa Ser Ser Gly Ala 
1               5                   10                  15      


Gly Val Pro Gly Gly Leu Phe Arg Ala Glu Pro Leu Tyr Ser Xaa Pro 
            20                  25                  30          


Arg Glu Pro Pro Arg Leu Xaa Pro Asn Met Ile Asn Ser Phe Val Val 
        35                  40                  45              


Asn Asn His Ser Asn Ser Ala Gly Gly Gly Gly Arg Gly Asn Xaa Asn 
    50                  55                  60                  


Xaa Asn Glu Cys Arg Met Val Asp Met His Gly Met Lys Val Ala Ser 
65                  70                  75                  80  


Phe Leu Met Asp Gly Gln Glu Leu Ile Cys Leu Pro Gln Val Phe Asp 
                85                  90                  95      


Leu Phe Leu Lys His Leu Val Gly Gly Leu His Xaa Val Tyr Xaa Lys 
            100                 105                 110         


Leu Lys Arg Leu Asp Ile Ser Pro Val Val Cys Xaa Val Glu Gln Val 
        115                 120                 125             


Arg Ile Leu Arg Gly Leu Gly Ala Ile Gln Pro Gly Val Asn Arg Cys 
    130                 135                 140                 


Lys Leu Ile Xaa Arg Lys Asp Phe Glu Xaa Leu Phe Xaa Asp Cys Xaa 
145                 150                 155                 160 


Asn Ala Arg Val Ser Leu Cys Cys Pro Gly Cys Ser Ala Val Val 
                165                 170                 175 


<210> 7534
<211> 571
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (447)..(447)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (500)..(501)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (538)..(539)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (550)..(550)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<400> 7534
Met Ala Val Ser Ala Ser Pro Val Ile Ser Ala Xaa Ser Ser Gly Ala 
1               5                   10                  15      


Gly Val Pro Gly Gly Leu Phe Arg Ala Glu Pro Leu Tyr Ser Xaa Pro 
            20                  25                  30          


Arg Glu Pro Pro Arg Leu Xaa Pro Asn Met Ile Asn Ser Phe Val Val 
        35                  40                  45              


Asn Asn His Ser Asn Ser Ala Gly Gly Gly Gly Arg Gly Asn Xaa Asn 
    50                  55                  60                  


Xaa Asn Glu Cys Arg Met Val Asp Met His Gly Met Lys Val Ala Ser 
65                  70                  75                  80  


Phe Leu Met Asp Gly Gln Glu Leu Ile Cys Leu Pro Gln Val Phe Asp 
                85                  90                  95      


Leu Phe Leu Lys His Leu Val Gly Gly Leu His Xaa Val Tyr Xaa Lys 
            100                 105                 110         


Leu Lys Arg Leu Asp Ile Ser Pro Val Val Cys Xaa Val Glu Gln Val 
        115                 120                 125             


Arg Ile Leu Arg Gly Leu Gly Ala Ile Gln Pro Gly Val Asn Arg Cys 
    130                 135                 140                 


Lys Leu Ile Xaa Arg Lys Asp Phe Glu Xaa Leu Phe Xaa Asp Cys Xaa 
145                 150                 155                 160 


Asn Ala Ser Ser Arg Pro Gly Arg Pro Pro Lys Arg Ser Leu Gly Val 
                165                 170                 175     


Leu Gln Glu Asn Ala Arg Leu Leu Xaa His Ala Val Pro Gly Leu Leu 
            180                 185                 190         


Ser Pro Gly Leu Ile Xaa Pro Xaa Gly Ile Xaa Ala Ala Ala Met Ala 
        195                 200                 205             


Glu Ala Met Lys Leu Gln Lys Met Lys Leu Met Ala Met Asn Xaa Leu 
    210                 215                 220                 


Gln Gly Asn Gly Ser Gln Asn Gly Xaa Glu Ser Glu Pro Asp Asp Leu 
225                 230                 235                 240 


Asn Ser Asn Xaa Gly Gly Ser Glu Ser Ser Trp Asp Lys Asp Lys Met 
                245                 250                 255     


Gln Ser Pro Phe Ala Ala Pro Gly Pro Gln His Gly Ile Ala His Ala 
            260                 265                 270         


Ala Leu Ala Gly Gln Pro Gly Ile Gly Gly Ala Pro Xaa Leu Asn Pro 
        275                 280                 285             


Leu Gln Gln Asn His Leu Leu Xaa Asn Arg Leu Asp Leu Pro Phe Met 
    290                 295                 300                 


Met Met Pro His Pro Leu Leu Pro Val Ser Leu Pro Pro Ala Ser Val 
305                 310                 315                 320 


Ala Met Ala Met Asn Gln Met Asn His Leu Asn Xaa Ile Ala Asn Met 
                325                 330                 335     


Ala Ala Ala Ala Gln Ile His Ser Pro Leu Ser Arg Ala Gly Xaa Ser 
            340                 345                 350         


Val Ile Lys Glu Arg Ile Pro Glu Ser Pro Ser Pro Ala Pro Ser Leu 
        355                 360                 365             


Glu Glu Asn His Arg Pro Gly Ser Gln Xaa Ser Ser His Xaa Ser Ser 
    370                 375                 380                 


Ser Val Ser Ser Ser Pro Ser Gln Met Asp His His Leu Glu Arg Met 
385                 390                 395                 400 


Glu Glu Val Pro Val Gln Ile Pro Ile Met Lys Ser Pro Leu Asp Lys 
                405                 410                 415     


Ile Gln Leu Xaa Pro Gly Gln Ala Leu Pro Ala Gly Phe Pro Gly Pro 
            420                 425                 430         


Phe Ile Phe Ala Asp Ser Leu Ser Ser Val Glu Xaa Leu Leu Xaa Asn 
        435                 440                 445             


Ile Gln Gly Leu Leu Lys Val Ala Leu Asp Asn Ala Arg Ile Gln Glu 
    450                 455                 460                 


Lys Gln Ile Gln Gln Glu Lys Lys Glu Leu Arg Leu Glu Leu Tyr Arg 
465                 470                 475                 480 


Glu Arg Glu Ile Arg Glu Asn Leu Glu Arg Gln Leu Ala Val Glu Leu 
                485                 490                 495     


Gln Ser Arg Xaa Xaa Met Gln Lys Arg Leu Lys Lys Glu Lys Lys Xaa 
            500                 505                 510         


Lys Arg Lys Leu Gln Glu Ala Leu Glu Phe Glu Ser Lys Arg Arg Glu 
        515                 520                 525             


Gln Val Glu Gln Ala Leu Lys Gln Ala Xaa Xaa Ser Asp Ser Gly Leu 
    530                 535                 540                 


Arg Met Leu Lys Asp Xaa Gly Ile Pro Asp Ile Glu Ile Glu Asn Asn 
545                 550                 555                 560 


Gly Xaa Pro His Asp Ser Ala Ala Met Gln Ala 
                565                 570     


<210> 7535
<211> 432
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (290)..(290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (346)..(347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(385)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (396)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<400> 7535
Met Xaa Arg Lys Gln Ala Val Asn Ser Ser Arg Pro Gly Arg Pro Pro 
1               5                   10                  15      


Lys Arg Ser Leu Gly Val Leu Gln Glu Asn Ala Arg Leu Leu Xaa His 
            20                  25                  30          


Ala Val Pro Gly Leu Leu Ser Pro Gly Leu Ile Xaa Pro Xaa Gly Ile 
        35                  40                  45              


Xaa Ala Ala Ala Met Ala Glu Ala Met Lys Leu Gln Lys Met Lys Leu 
    50                  55                  60                  


Met Ala Met Asn Xaa Leu Gln Gly Asn Gly Ser Gln Asn Gly Xaa Glu 
65                  70                  75                  80  


Ser Glu Pro Asp Asp Leu Asn Ser Asn Xaa Gly Gly Ser Glu Ser Ser 
                85                  90                  95      


Trp Asp Lys Asp Lys Met Gln Ser Pro Phe Ala Ala Pro Gly Pro Gln 
            100                 105                 110         


His Gly Ile Ala His Ala Ala Leu Ala Gly Gln Pro Gly Ile Gly Gly 
        115                 120                 125             


Ala Pro Xaa Leu Asn Pro Leu Gln Gln Asn His Leu Leu Xaa Asn Arg 
    130                 135                 140                 


Leu Asp Leu Pro Phe Met Met Met Pro His Pro Leu Leu Pro Val Ser 
145                 150                 155                 160 


Leu Pro Pro Ala Ser Val Ala Met Ala Met Asn Gln Met Asn His Leu 
                165                 170                 175     


Asn Xaa Ile Ala Asn Met Ala Ala Ala Ala Gln Ile His Ser Pro Leu 
            180                 185                 190         


Ser Arg Ala Gly Xaa Ser Val Ile Lys Glu Arg Ile Pro Glu Ser Pro 
        195                 200                 205             


Ser Pro Ala Pro Ser Leu Glu Glu Asn His Arg Pro Gly Ser Gln Xaa 
    210                 215                 220                 


Ser Ser His Xaa Ser Ser Ser Val Ser Ser Ser Pro Ser Gln Met Asp 
225                 230                 235                 240 


His His Leu Glu Arg Met Glu Glu Val Pro Val Gln Ile Pro Ile Met 
                245                 250                 255     


Lys Ser Pro Leu Asp Lys Ile Gln Leu Xaa Pro Gly Gln Ala Leu Pro 
            260                 265                 270         


Ala Gly Phe Pro Gly Pro Phe Ile Phe Ala Asp Ser Leu Ser Ser Val 
        275                 280                 285             


Glu Xaa Leu Leu Xaa Asn Ile Gln Gly Leu Leu Lys Val Ala Leu Asp 
    290                 295                 300                 


Asn Ala Arg Ile Gln Glu Lys Gln Ile Gln Gln Glu Lys Lys Glu Leu 
305                 310                 315                 320 


Arg Leu Glu Leu Tyr Arg Glu Arg Glu Ile Arg Glu Asn Leu Glu Arg 
                325                 330                 335     


Gln Leu Ala Val Glu Leu Gln Ser Arg Xaa Xaa Met Gln Lys Arg Leu 
            340                 345                 350         


Lys Lys Glu Lys Lys Xaa Lys Arg Lys Leu Gln Glu Ala Leu Glu Phe 
        355                 360                 365             


Glu Ser Lys Arg Arg Glu Gln Val Glu Gln Ala Leu Lys Gln Ala Xaa 
    370                 375                 380                 


Xaa Ser Asp Ser Gly Leu Arg Met Leu Lys Asp Xaa Gly Ile Pro Asp 
385                 390                 395                 400 


Ile Glu Ile Glu Asn Asn Gly Xaa Pro His Asp Ser Ala Ala Met Gln 
                405                 410                 415     


Gly Gly Asn Tyr Tyr Cys Leu Glu Met Ala Gln Gln Leu Tyr Ser Ala 
            420                 425                 430         


<210> 7536
<211> 427
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Selenocysteine

<400> 7536
Ser Val Asn Ser Ser Arg Pro Gly Arg Pro Pro Lys Arg Ser Leu Gly 
1               5                   10                  15      


Val Leu Gln Glu Asn Ala Arg Leu Leu Xaa His Ala Val Pro Gly Leu 
            20                  25                  30          


Leu Ser Pro Gly Leu Ile Xaa Pro Xaa Gly Ile Xaa Ala Ala Ala Met 
        35                  40                  45              


Ala Glu Ala Met Lys Leu Gln Lys Met Lys Leu Met Ala Met Asn Xaa 
    50                  55                  60                  


Leu Gln Gly Asn Gly Ser Gln Asn Gly Xaa Glu Ser Glu Pro Asp Asp 
65                  70                  75                  80  


Leu Asn Ser Asn Xaa Gly Gly Ser Glu Ser Ser Trp Asp Lys Asp Lys 
                85                  90                  95      


Met Gln Ser Pro Phe Ala Ala Pro Gly Pro Gln His Gly Ile Ala His 
            100                 105                 110         


Ala Ala Leu Ala Gly Gln Pro Gly Ile Gly Gly Ala Pro Xaa Leu Asn 
        115                 120                 125             


Pro Leu Gln Gln Asn His Leu Leu Xaa Asn Arg Leu Asp Leu Pro Phe 
    130                 135                 140                 


Met Met Met Pro His Pro Leu Leu Pro Val Ser Leu Pro Pro Ala Ser 
145                 150                 155                 160 


Val Ala Met Ala Met Asn Gln Met Asn His Leu Asn Xaa Ile Ala Asn 
                165                 170                 175     


Met Ala Ala Ala Ala Gln Ile His Ser Pro Leu Ser Arg Ala Gly Xaa 
            180                 185                 190         


Ser Val Ile Lys Glu Arg Ile Pro Glu Ser Pro Ser Pro Ala Pro Ser 
        195                 200                 205             


Leu Glu Glu Asn His Arg Pro Gly Ser Gln Xaa Ser Ser His Xaa Ser 
    210                 215                 220                 


Ser Ser Val Ser Ser Ser Pro Ser Gln Met Asp His His Leu Glu Arg 
225                 230                 235                 240 


Met Glu Glu Val Pro Val Gln Ile Pro Ile Met Lys Ser Pro Leu Asp 
                245                 250                 255     


Lys Ile Gln Leu Xaa Pro Gly Gln Ala Leu Pro Ala Gly Phe Pro Gly 
            260                 265                 270         


Pro Phe Ile Phe Ala Asp Ser Leu Ser Ser Val Glu Xaa Leu Leu Xaa 
        275                 280                 285             


Asn Ile Gln Gly Leu Leu Lys Val Ala Leu Asp Asn Ala Arg Ile Gln 
    290                 295                 300                 


Glu Lys Gln Ile Gln Gln Glu Lys Lys Glu Leu Arg Leu Glu Leu Tyr 
305                 310                 315                 320 


Arg Glu Arg Glu Ile Arg Glu Asn Leu Glu Arg Gln Leu Ala Val Glu 
                325                 330                 335     


Leu Gln Ser Arg Xaa Xaa Met Gln Lys Arg Leu Lys Lys Glu Lys Lys 
            340                 345                 350         


Xaa Lys Arg Lys Leu Gln Glu Ala Leu Glu Phe Glu Ser Lys Arg Arg 
        355                 360                 365             


Glu Gln Val Glu Gln Ala Leu Lys Gln Ala Xaa Xaa Ser Asp Ser Gly 
    370                 375                 380                 


Leu Arg Met Leu Lys Asp Xaa Gly Ile Pro Asp Ile Glu Ile Glu Asn 
385                 390                 395                 400 


Asn Gly Xaa Pro His Asp Ser Ala Ala Met Gln Gly Gly Asn Tyr Tyr 
                405                 410                 415     


Cys Leu Glu Met Ala Gln Gln Leu Tyr Ser Ala 
            420                 425         


<210> 7537
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 7537
Met Phe Leu Leu Cys Leu Xaa Gly Asn Pro Leu Arg Glu Glu Asp Arg 
1               5                   10                  15      


Leu Gly Asn His Ala Ser Asp Ile Cys Gly Gly Ser Glu Leu Asp Ala 
            20                  25                  30          


Val Lys Xaa Asp Ser Ser Leu Pro Ser Pro Ser Ser Leu Trp Ser Ala 
        35                  40                  45              


Ser His Pro Ser Ser Ser Lys Lys Met Asp Gly Tyr Ile Leu Ser Leu 
    50                  55                  60                  


Val Gln Lys Lys Xaa His Pro Val Arg Xaa Asn Lys Pro Arg Xaa Ser 
65                  70                  75                  80  


Val Asn Ala Asp Pro Xaa Lys Gly Leu Leu Arg Asn Gly Ser Val Cys 
                85                  90                  95      


Val Arg Ala Pro Gly Gly Val Ser Gln Gly Asn Ser Val Asn Leu Lys 
            100                 105                 110         


Asn Ser Lys Gln Ala Cys Leu Pro Ser Gly Gly Ile Pro Ser Leu Asn 
        115                 120                 125             


Asn Gly 
    130 


<210> 7538
<211> 555
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (393)..(393)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (456)..(456)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (490)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (527)..(527)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (553)..(554)
<223> Selenocysteine

<400> 7538
Met Phe Leu Leu Cys Leu Xaa Gly Asn Pro Leu Arg Glu Glu Asp Arg 
1               5                   10                  15      


Leu Gly Asn His Ala Ser Asp Ile Cys Gly Gly Ser Glu Leu Asp Ala 
            20                  25                  30          


Val Lys Xaa Asp Ser Ser Leu Pro Ser Pro Ser Ser Leu Trp Ser Ala 
        35                  40                  45              


Ser His Pro Ser Ser Ser Lys Lys Met Asp Gly Tyr Ile Leu Ser Leu 
    50                  55                  60                  


Val Gln Lys Lys Xaa His Pro Val Arg Xaa Asn Lys Pro Arg Xaa Ser 
65                  70                  75                  80  


Val Asn Ala Asp Pro Xaa Lys Gly Leu Leu Arg Asn Gly Ser Val Cys 
                85                  90                  95      


Val Arg Ala Pro Gly Gly Val Ser Gln Gly Asn Ser Val Asn Leu Lys 
            100                 105                 110         


Asn Ser Lys Gln Ala Cys Leu Pro Ser Gly Gly Ile Pro Ser Leu Asn 
        115                 120                 125             


Asn Gly Xaa Phe Ser Pro Pro Lys Gln Trp Ser Lys Glu Ser Lys Ala 
    130                 135                 140                 


Glu Gln Ala Glu Ser Lys Arg Val Pro Leu Pro Glu Gly Cys Pro Ser 
145                 150                 155                 160 


Gly Ala Ala Ser Asp Leu Gln Ser Lys His Leu Pro Lys Xaa Ala Lys 
                165                 170                 175     


Pro Ala Ser Gln Glu His Ala Arg Cys Ser Ala Ile Gly Xaa Gly Glu 
            180                 185                 190         


Ser Pro Lys Glu Ser Ala Gln Leu Ser Gly Ala Ser Pro Lys Glu Ser 
        195                 200                 205             


Pro Ser Arg Gly Pro Ala Pro Pro Gln Glu Asn Lys Val Val Gln Pro 
    210                 215                 220                 


Leu Lys Lys Met Ser Gln Lys Asn Ser Leu Gln Gly Val Pro Pro Ala 
225                 230                 235                 240 


Xaa Pro Pro Leu Leu Ser Xaa Ala Phe Pro Val Glu Glu Arg Pro Ala 
                245                 250                 255     


Leu Asp Phe Lys Ser Glu Gly Ser Ser Gln Ser Leu Glu Glu Ala His 
            260                 265                 270         


Leu Val Lys Ala Gln Phe Ile Pro Gly Gln Gln Pro Ser Val Arg Leu 
        275                 280                 285             


His Arg Gly His Arg Asn Met Gly Val Val Lys Asn Ser Ser Leu Lys 
    290                 295                 300                 


His Arg Gly Pro Ala Leu Gln Gly Leu Glu Asn Gly Leu Pro Xaa Val 
305                 310                 315                 320 


Arg Glu Lys Xaa Arg Ala Gly Ser Lys Lys Cys Arg Phe Pro Asp Asp 
                325                 330                 335     


Leu Asp Xaa Asn Lys Lys Leu Lys Lys Ala Ser Ser Lys Gly Arg Lys 
            340                 345                 350         


Ser Gly Gly Gly Pro Glu Ala Gly Val Pro Gly Arg Pro Ala Gly Gly 
        355                 360                 365             


Gly His Arg Ala Gly Ser Arg Ala His Gly His Gly Arg Glu Ala Val 
    370                 375                 380                 


Val Ala Lys Pro Lys His Lys Arg Xaa Asp Tyr Arg Arg Trp Lys Ser 
385                 390                 395                 400 


Ser Ala Glu Ile Ser Tyr Glu Glu Ala Leu Arg Arg Ala Arg Arg Gly 
                405                 410                 415     


Arg Arg Glu Asn Val Gly Leu Tyr Pro Ala Pro Val Pro Leu Pro Tyr 
            420                 425                 430         


Ala Ser Pro Tyr Ala Tyr Val Ala Ser Asp Ser Glu Tyr Ser Ala Glu 
        435                 440                 445             


Cys Glu Ser Leu Phe His Ser Xaa Val Val Asp Xaa Ser Glu Asp Glu 
    450                 455                 460                 


Gln Ser Asn Tyr Xaa Xaa Asn Cys Phe Gly Asp Ser Glu Ser Ser Val 
465                 470                 475                 480 


Ser Glu Gly Glu Phe Val Gly Glu Ser Xaa Xaa Xaa Ser Asp Ser Glu 
                485                 490                 495     


Glu Ser Gly Gly Leu Ile Trp Ser Gln Phe Val Gln Xaa Leu Pro Ile 
            500                 505                 510         


Gln Xaa Val Xaa Ala Pro Asp Leu His Asn His Pro Ala Lys Xaa Phe 
        515                 520                 525             


Val Lys Ile Lys Ala Ser His Asn Leu Lys Lys Lys Ile Leu Arg Phe 
    530                 535                 540                 


Arg Ser Gly Ser Leu Lys Leu Met Xaa Xaa Val 
545                 550                 555 


<210> 7539
<211> 836
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (288)..(288)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (471)..(471)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (600)..(600)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (605)..(605)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (674)..(674)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (750)..(751)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(773)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (834)..(835)
<223> Selenocysteine

<400> 7539
Met Lys Pro Ser Pro Ala Gly Xaa Ala Lys Glu Leu Glu Pro Pro Ala 
1               5                   10                  15      


Pro Ala Arg Gly Glu Gln Arg Xaa Ala Glu Pro Glu Gly Arg Trp Arg 
            20                  25                  30          


Glu Lys Gly Glu Ala Asp Xaa Glu Arg Gln Arg Xaa Arg Glu Arg Gln 
        35                  40                  45              


Glu Ala Xaa Leu Ala Gly Leu Ala Glu Leu Glu Tyr Leu Arg Gln Arg 
    50                  55                  60                  


Gln Glu Leu Leu Val Arg Gly Ala Leu Arg Gly Ala Gly Gly Ala Gly 
65                  70                  75                  80  


Ala Ala Ala Pro Arg Ala Gly Glu Leu Leu Gly Glu Ala Ala Gln Arg 
                85                  90                  95      


Ser Arg Leu Glu Glu Lys Phe Leu Glu Glu Asn Ile Leu Leu Leu Arg 
            100                 105                 110         


Lys Gln Leu Asn Cys Leu Arg Arg Arg Asp Ala Gly Leu Leu Asn Gln 
        115                 120                 125             


Leu Gln Glu Leu Asp Lys Gln Ile Ser Asp Leu Arg Leu Asp Val Glu 
    130                 135                 140                 


Lys Xaa Ser Glu Glu His Leu Glu Xaa Asp Ser Arg Pro Ser Ser Gly 
145                 150                 155                 160 


Phe Tyr Glu Leu Ser Asp Gly Ala Ser Gly Ser Leu Ser Asn Ser Ser 
                165                 170                 175     


Asn Ser Val Phe Ser Glu Cys Leu Ser Ser Cys His Ser Ser Xaa Cys 
            180                 185                 190         


Phe Cys Ser Pro Leu Glu Ala Xaa Leu Ser Leu Ser Asp Gly Cys Pro 
        195                 200                 205             


Lys Ser Ala Asp Leu Ile Gly Leu Leu Glu Tyr Lys Glu Gly His Cys 
    210                 215                 220                 


Glu Asp Gln Ala Ser Gly Ala Val Cys Arg Ser Leu Ser Xaa Pro Gln 
225                 230                 235                 240 


Phe Asn Ser Leu Asp Val Ile Ala Asp Val Asn Pro Lys Tyr Gln Cys 
                245                 250                 255     


Asp Leu Val Ser Lys Asn Gly Asn Asp Val Tyr Arg Tyr Pro Ser Pro 
            260                 265                 270         


Leu His Ala Val Ala Val Gln Ser Pro Met Phe Leu Leu Cys Leu Xaa 
        275                 280                 285             


Gly Asn Pro Leu Arg Glu Glu Asp Arg Leu Gly Asn His Ala Ser Asp 
    290                 295                 300                 


Ile Cys Gly Gly Ser Glu Leu Asp Ala Val Lys Xaa Asp Ser Ser Leu 
305                 310                 315                 320 


Pro Ser Pro Ser Ser Leu Trp Ser Ala Ser His Pro Ser Ser Ser Lys 
                325                 330                 335     


Lys Met Asp Gly Tyr Ile Leu Ser Leu Val Gln Lys Lys Xaa His Pro 
            340                 345                 350         


Val Arg Xaa Asn Lys Pro Arg Xaa Ser Val Asn Ala Asp Pro Xaa Lys 
        355                 360                 365             


Gly Leu Leu Arg Asn Gly Ser Val Cys Val Arg Ala Pro Gly Gly Val 
    370                 375                 380                 


Ser Gln Gly Asn Ser Val Asn Leu Lys Asn Ser Lys Gln Ala Cys Leu 
385                 390                 395                 400 


Pro Ser Gly Gly Ile Pro Ser Leu Asn Asn Gly Xaa Phe Ser Pro Pro 
                405                 410                 415     


Lys Gln Trp Ser Lys Glu Ser Lys Ala Glu Gln Ala Glu Ser Lys Arg 
            420                 425                 430         


Val Pro Leu Pro Glu Gly Cys Pro Ser Gly Ala Ala Ser Asp Leu Gln 
        435                 440                 445             


Ser Lys His Leu Pro Lys Xaa Ala Lys Pro Ala Ser Gln Glu His Ala 
    450                 455                 460                 


Arg Cys Ser Ala Ile Gly Xaa Gly Glu Ser Pro Lys Glu Ser Ala Gln 
465                 470                 475                 480 


Leu Ser Gly Ala Ser Pro Lys Glu Ser Pro Ser Arg Gly Pro Ala Pro 
                485                 490                 495     


Pro Gln Glu Asn Lys Val Val Gln Pro Leu Lys Lys Met Ser Gln Lys 
            500                 505                 510         


Asn Ser Leu Gln Gly Val Pro Pro Ala Xaa Pro Pro Leu Leu Ser Xaa 
        515                 520                 525             


Ala Phe Pro Val Glu Glu Arg Pro Ala Leu Asp Phe Lys Ser Glu Gly 
    530                 535                 540                 


Ser Ser Gln Ser Leu Glu Glu Ala His Leu Val Lys Ala Gln Phe Ile 
545                 550                 555                 560 


Pro Gly Gln Gln Pro Ser Val Arg Leu His Arg Gly His Arg Asn Met 
                565                 570                 575     


Gly Val Val Lys Asn Ser Ser Leu Lys His Arg Gly Pro Ala Leu Gln 
            580                 585                 590         


Gly Leu Glu Asn Gly Leu Pro Xaa Val Arg Glu Lys Xaa Arg Ala Gly 
        595                 600                 605             


Ser Lys Lys Cys Arg Phe Pro Asp Asp Leu Asp Xaa Asn Lys Lys Leu 
    610                 615                 620                 


Lys Lys Ala Ser Ser Lys Gly Arg Lys Ser Gly Gly Gly Pro Glu Ala 
625                 630                 635                 640 


Gly Val Pro Gly Arg Pro Ala Gly Gly Gly His Arg Ala Gly Ser Arg 
                645                 650                 655     


Ala His Gly His Gly Arg Glu Ala Val Val Ala Lys Pro Lys His Lys 
            660                 665                 670         


Arg Xaa Asp Tyr Arg Arg Trp Lys Ser Ser Ala Glu Ile Ser Tyr Glu 
        675                 680                 685             


Glu Ala Leu Arg Arg Ala Arg Arg Gly Arg Arg Glu Asn Val Gly Leu 
    690                 695                 700                 


Tyr Pro Ala Pro Val Pro Leu Pro Tyr Ala Ser Pro Tyr Ala Tyr Val 
705                 710                 715                 720 


Ala Ser Asp Ser Glu Tyr Ser Ala Glu Cys Glu Ser Leu Phe His Ser 
                725                 730                 735     


Xaa Val Val Asp Xaa Ser Glu Asp Glu Gln Ser Asn Tyr Xaa Xaa Asn 
            740                 745                 750         


Cys Phe Gly Asp Ser Glu Ser Ser Val Ser Glu Gly Glu Phe Val Gly 
        755                 760                 765             


Glu Ser Xaa Xaa Xaa Ser Asp Ser Glu Glu Ser Gly Gly Leu Ile Trp 
    770                 775                 780                 


Ser Gln Phe Val Gln Xaa Leu Pro Ile Gln Xaa Val Xaa Ala Pro Asp 
785                 790                 795                 800 


Leu His Asn His Pro Ala Lys Xaa Phe Val Lys Ile Lys Ala Ser His 
                805                 810                 815     


Asn Leu Lys Lys Lys Ile Leu Arg Phe Arg Ser Gly Ser Leu Lys Leu 
            820                 825                 830         


Met Xaa Xaa Val 
        835     


<210> 7540
<211> 799
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (251)..(251)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (323)..(323)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (485)..(485)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (568)..(568)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (637)..(637)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (704)..(704)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (713)..(714)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(736)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (797)..(798)
<223> Selenocysteine

<400> 7540
Met Lys Pro Ser Pro Ala Gly Xaa Ala Lys Glu Leu Glu Pro Pro Ala 
1               5                   10                  15      


Pro Ala Arg Gly Glu Gln Arg Xaa Ala Glu Pro Glu Gly Arg Trp Arg 
            20                  25                  30          


Glu Lys Gly Glu Ala Asp Xaa Glu Arg Gln Arg Xaa Arg Glu Arg Gln 
        35                  40                  45              


Glu Ala Xaa Leu Ala Gly Leu Ala Glu Leu Glu Tyr Leu Arg Gln Arg 
    50                  55                  60                  


Gln Glu Leu Leu Val Arg Gly Ala Leu Arg Gly Ala Gly Gly Ala Gly 
65                  70                  75                  80  


Ala Ala Ala Pro Arg Ala Gly Glu Leu Leu Gly Glu Ala Ala Gln Arg 
                85                  90                  95      


Ser Arg Leu Glu Glu Lys Phe Leu Glu Glu Asn Ile Leu Leu Leu Arg 
            100                 105                 110         


Lys Gln Leu Asn Cys Leu Arg Arg Arg Asp Ala Gly Leu Leu Asn Gln 
        115                 120                 125             


Leu Gln Glu Leu Asp Lys Gln Ile Ser Asp Leu Arg Leu Asp Val Glu 
    130                 135                 140                 


Lys Xaa Ser Glu Glu His Leu Glu Xaa Asp Ser Arg Pro Ser Ser Gly 
145                 150                 155                 160 


Phe Tyr Glu Leu Ser Asp Gly Ala Ser Gly Ser Leu Ser Asn Ser Ser 
                165                 170                 175     


Asn Ser Val Phe Ser Glu Cys Leu Ser Ser Cys His Ser Ser Xaa Cys 
            180                 185                 190         


Phe Cys Ser Pro Leu Glu Ala Xaa Leu Ser Leu Ser Asp Gly Cys Pro 
        195                 200                 205             


Lys Ser Ala Asp Val Asn Pro Lys Tyr Gln Cys Asp Leu Val Ser Lys 
    210                 215                 220                 


Asn Gly Asn Asp Val Tyr Arg Tyr Pro Ser Pro Leu His Ala Val Ala 
225                 230                 235                 240 


Val Gln Ser Pro Met Phe Leu Leu Cys Leu Xaa Gly Asn Pro Leu Arg 
                245                 250                 255     


Glu Glu Asp Arg Leu Gly Asn His Ala Ser Asp Ile Cys Gly Gly Ser 
            260                 265                 270         


Glu Leu Asp Ala Val Lys Xaa Asp Ser Ser Leu Pro Ser Pro Ser Ser 
        275                 280                 285             


Leu Trp Ser Ala Ser His Pro Ser Ser Ser Lys Lys Met Asp Gly Tyr 
    290                 295                 300                 


Ile Leu Ser Leu Val Gln Lys Lys Xaa His Pro Val Arg Xaa Asn Lys 
305                 310                 315                 320 


Pro Arg Xaa Ser Val Asn Ala Asp Pro Xaa Lys Gly Leu Leu Arg Asn 
                325                 330                 335     


Gly Ser Val Cys Val Arg Ala Pro Gly Gly Val Ser Gln Gly Asn Ser 
            340                 345                 350         


Val Asn Leu Lys Asn Ser Lys Gln Ala Cys Leu Pro Ser Gly Gly Ile 
        355                 360                 365             


Pro Ser Leu Asn Asn Gly Xaa Phe Ser Pro Pro Lys Gln Trp Ser Lys 
    370                 375                 380                 


Glu Ser Lys Ala Glu Gln Ala Glu Ser Lys Arg Val Pro Leu Pro Glu 
385                 390                 395                 400 


Gly Cys Pro Ser Gly Ala Ala Ser Asp Leu Gln Ser Lys His Leu Pro 
                405                 410                 415     


Lys Xaa Ala Lys Pro Ala Ser Gln Glu His Ala Arg Cys Ser Ala Ile 
            420                 425                 430         


Gly Xaa Gly Glu Ser Pro Lys Glu Ser Ala Gln Leu Ser Gly Ala Ser 
        435                 440                 445             


Pro Lys Glu Ser Pro Ser Arg Gly Pro Ala Pro Pro Gln Glu Asn Lys 
    450                 455                 460                 


Val Val Gln Pro Leu Lys Lys Met Ser Gln Lys Asn Ser Leu Gln Gly 
465                 470                 475                 480 


Val Pro Pro Ala Xaa Pro Pro Leu Leu Ser Xaa Ala Phe Pro Val Glu 
                485                 490                 495     


Glu Arg Pro Ala Leu Asp Phe Lys Ser Glu Gly Ser Ser Gln Ser Leu 
            500                 505                 510         


Glu Glu Ala His Leu Val Lys Ala Gln Phe Ile Pro Gly Gln Gln Pro 
        515                 520                 525             


Ser Val Arg Leu His Arg Gly His Arg Asn Met Gly Val Val Lys Asn 
    530                 535                 540                 


Ser Ser Leu Lys His Arg Gly Pro Ala Leu Gln Gly Leu Glu Asn Gly 
545                 550                 555                 560 


Leu Pro Xaa Val Arg Glu Lys Xaa Arg Ala Gly Ser Lys Lys Cys Arg 
                565                 570                 575     


Phe Pro Asp Asp Leu Asp Xaa Asn Lys Lys Leu Lys Lys Ala Ser Ser 
            580                 585                 590         


Lys Gly Arg Lys Ser Gly Gly Gly Pro Glu Ala Gly Val Pro Gly Arg 
        595                 600                 605             


Pro Ala Gly Gly Gly His Arg Ala Gly Ser Arg Ala His Gly His Gly 
    610                 615                 620                 


Arg Glu Ala Val Val Ala Lys Pro Lys His Lys Arg Xaa Asp Tyr Arg 
625                 630                 635                 640 


Arg Trp Lys Ser Ser Ala Glu Ile Ser Tyr Glu Glu Ala Leu Arg Arg 
                645                 650                 655     


Ala Arg Arg Gly Arg Arg Glu Asn Val Gly Leu Tyr Pro Ala Pro Val 
            660                 665                 670         


Pro Leu Pro Tyr Ala Ser Pro Tyr Ala Tyr Val Ala Ser Asp Ser Glu 
        675                 680                 685             


Tyr Ser Ala Glu Cys Glu Ser Leu Phe His Ser Xaa Val Val Asp Xaa 
    690                 695                 700                 


Ser Glu Asp Glu Gln Ser Asn Tyr Xaa Xaa Asn Cys Phe Gly Asp Ser 
705                 710                 715                 720 


Glu Ser Ser Val Ser Glu Gly Glu Phe Val Gly Glu Ser Xaa Xaa Xaa 
                725                 730                 735     


Ser Asp Ser Glu Glu Ser Gly Gly Leu Ile Trp Ser Gln Phe Val Gln 
            740                 745                 750         


Xaa Leu Pro Ile Gln Xaa Val Xaa Ala Pro Asp Leu His Asn His Pro 
        755                 760                 765             


Ala Lys Xaa Phe Val Lys Ile Lys Ala Ser His Asn Leu Lys Lys Lys 
    770                 775                 780                 


Ile Leu Arg Phe Arg Ser Gly Ser Leu Lys Leu Met Xaa Xaa Val 
785                 790                 795                 


<210> 7541
<211> 604
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (149)..(149)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (415)..(415)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(521)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (596)..(596)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<400> 7541
Met Gly Asp Trp Arg Pro Arg Ser Val Asp Glu Xaa Xaa Val Pro Ala 
1               5                   10                  15      


Trp Arg Pro Gln Ala Xaa Glu Glu Gly Ala Arg Pro Pro Gly Ser Val 
            20                  25                  30          


Glu Asp Ala Gly Gln Pro Trp Gly Xaa Phe Trp Pro Arg Pro Val Ser 
        35                  40                  45              


Xaa Gly Asp Leu Asp Arg Ala Leu Pro Ala Asp Xaa Gly Leu Gln Lys 
    50                  55                  60                  


Ala Ser Ala Asp Ala Glu Leu Leu Gly Leu Leu Cys Gln Gly Val Asp 
65                  70                  75                  80  


Ile Pro Leu His Val Pro Asp Pro Lys Tyr Arg Gln Asp Leu Val Ser 
                85                  90                  95      


Gln Gly Gly Arg Glu Val Tyr Pro Tyr Pro Ser Pro Leu His Ala Val 
            100                 105                 110         


Ala Leu Gln Ser Pro Leu Phe Val Leu Xaa Lys Glu Xaa Pro Gln Arg 
        115                 120                 125             


Gly Gly Pro Ser Phe Pro Arg Glu Ser Pro Arg Gly Pro Ala Gly Leu 
    130                 135                 140                 


Asn Xaa Ile Gln Xaa Gly Pro Val Leu Glu Ala Gly Pro Ala Arg Ala 
145                 150                 155                 160 


Arg Ala Tyr Ile Asp Arg Leu Leu His Leu Trp Gly Arg Glu Xaa Pro 
                165                 170                 175     


Ala Lys Gly Ser Glu Gly Glu Gln Gly Pro Leu Arg His Ala Ala Ser 
            180                 185                 190         


Pro Ser Pro Gln Arg Gln Gly Gly Trp Ser Xaa Asp Gly Gly Gly Arg 
        195                 200                 205             


Leu Leu Val Phe Ala Pro Gly Arg Glu Asp Glu Gly Gly Pro Ala Gln 
    210                 215                 220                 


Ser Arg Gly Ala Gly Arg Gly Gly Pro Gln Gln Gln Gly Tyr Met Pro 
225                 230                 235                 240 


Leu Glu Gly Pro Gln Gln Ser Gly Ser Leu Pro Glu Glu Gly Ser Lys 
                245                 250                 255     


Pro Ser Asn Ser Cys Val Leu Arg Glu Xaa Met Val Gln Ala Ser Pro 
            260                 265                 270         


Ser Ser Lys Ala Gln Gln Xaa Pro Ser Ala Gln Asp Tyr Gly Arg Gly 
        275                 280                 285             


Asn Ile Ile Ser Pro Ser Arg Met Leu Asp Lys Ser Pro Ser Pro Ala 
    290                 295                 300                 


Ser Gly His Phe Ala His Pro Ser Phe Ala Ala Ser Leu Lys Met Gly 
305                 310                 315                 320 


Pro Pro Lys Ser Lys Ala Glu Lys Ile Lys Arg Ser Pro Met Asp Lys 
                325                 330                 335     


Val Leu Arg Phe Ala Arg Gln Pro Leu Leu Leu Leu Asp Arg Pro Glu 
            340                 345                 350         


Gly Ala His Ala Ala Pro Gln Pro Ser Leu Glu Trp Asp Pro Ala His 
        355                 360                 365             


Trp Pro Xaa Gly Arg Gly Gly Leu Gln Arg Arg Pro Ala Leu Ala Trp 
    370                 375                 380                 


Glu Ala Pro Gly Arg Ser Cys Ser Glu Ser Xaa Leu Tyr Pro Met Pro 
385                 390                 395                 400 


Val Leu Val Pro Leu Ala Val Ala Pro Gln Glu Ser His Arg Xaa Ser 
                405                 410                 415     


Ala Gln Ala Leu Phe Pro Phe Glu Ala Ser Leu Leu Xaa Ser Val Ala 
            420                 425                 430         


Arg Arg Lys His Arg Arg Trp Gln Ser Xaa Val Glu Ile Ser Ala Arg 
        435                 440                 445             


Ala Arg Leu Ala Ser Cys Pro Glu Ser Asn Leu Gly Pro Pro Arg Pro 
    450                 455                 460                 


Val Ala Arg Arg Ala Gly Gly Pro Leu Ala Arg Gly Arg Pro Ser Leu 
465                 470                 475                 480 


Val Arg Gln Asp Ala Tyr Xaa Arg Ser Asp Ser Glu Pro Ser Lys His 
                485                 490                 495     


Ser Ala Glu Cys Asp Pro Arg Phe Pro Ser Val Ile Pro Glu Xaa Ser 
            500                 505                 510         


Glu Gly Glu Ser Ser Asp His Xaa Xaa Asn Arg Phe Gly Asp Arg Glu 
        515                 520                 525             


Ser Ser Ser Ser Asp Glu Glu Gly Gly Ala Gln Ser Arg Asp Cys Asp 
    530                 535                 540                 


Leu Ala Leu Gly Tyr Val Ala Ala Gly His Ala Glu Leu Ala Trp Xaa 
545                 550                 555                 560 


Gln Glu Ala Pro Val Ser Ser Gly Pro Leu Leu Ser Pro Val Pro Lys 
                565                 570                 575     


Leu Cys Arg Ile Lys Ala Ser Lys Ala Leu Lys Lys Lys Ile Arg Arg 
            580                 585                 590         


Phe Gln Pro Xaa Ala Leu Lys Val Met Xaa Met Val 
        595                 600                 


<210> 7542
<211> 366
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (157)..(157)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<400> 7542
Met Pro Leu Glu Gly Pro Gln Gln Ser Gly Ser Leu Pro Glu Glu Gly 
1               5                   10                  15      


Ser Lys Pro Ser Asn Ser Cys Val Leu Arg Glu Xaa Met Val Gln Ala 
            20                  25                  30          


Ser Pro Ser Ser Lys Ala Gln Gln Xaa Pro Ser Ala Gln Asp Tyr Gly 
        35                  40                  45              


Arg Gly Asn Ile Ile Ser Pro Ser Arg Met Leu Asp Lys Ser Pro Ser 
    50                  55                  60                  


Pro Ala Ser Gly His Phe Ala His Pro Ser Phe Ala Ala Ser Leu Lys 
65                  70                  75                  80  


Met Gly Pro Pro Lys Ser Lys Ala Glu Lys Ile Lys Arg Ser Pro Met 
                85                  90                  95      


Asp Lys Val Leu Arg Phe Ala Arg Gln Pro Leu Leu Leu Leu Asp Arg 
            100                 105                 110         


Pro Glu Gly Ala His Ala Ala Pro Gln Pro Ser Leu Glu Trp Asp Pro 
        115                 120                 125             


Ala His Trp Pro Xaa Gly Arg Gly Gly Leu Gln Arg Arg Pro Ala Leu 
    130                 135                 140                 


Ala Trp Glu Ala Pro Gly Arg Ser Cys Ser Glu Ser Xaa Leu Tyr Pro 
145                 150                 155                 160 


Met Pro Val Leu Val Pro Leu Ala Val Ala Pro Gln Glu Ser His Arg 
                165                 170                 175     


Xaa Ser Ala Gln Ala Leu Phe Pro Phe Glu Ala Ser Leu Leu Xaa Ser 
            180                 185                 190         


Val Ala Arg Arg Lys His Arg Arg Trp Gln Ser Xaa Val Glu Ile Ser 
        195                 200                 205             


Ala Arg Ala Arg Leu Ala Ser Cys Pro Glu Ser Asn Leu Gly Pro Pro 
    210                 215                 220                 


Arg Pro Val Ala Arg Arg Ala Gly Gly Pro Leu Ala Arg Gly Arg Pro 
225                 230                 235                 240 


Ser Leu Val Arg Gln Asp Ala Tyr Xaa Arg Ser Asp Ser Glu Pro Ser 
                245                 250                 255     


Lys His Ser Ala Glu Cys Asp Pro Arg Phe Pro Ser Val Ile Pro Glu 
            260                 265                 270         


Xaa Ser Glu Gly Glu Ser Ser Asp His Xaa Xaa Asn Arg Phe Gly Asp 
        275                 280                 285             


Arg Glu Ser Ser Ser Ser Asp Glu Glu Gly Gly Ala Gln Ser Arg Asp 
    290                 295                 300                 


Cys Asp Leu Ala Leu Gly Tyr Val Ala Ala Gly His Ala Glu Leu Ala 
305                 310                 315                 320 


Trp Xaa Gln Glu Ala Pro Val Ser Ser Gly Pro Leu Leu Ser Pro Val 
                325                 330                 335     


Pro Lys Leu Cys Arg Ile Lys Ala Ser Lys Ala Leu Lys Lys Lys Ile 
            340                 345                 350         


Arg Arg Phe Gln Pro Xaa Ala Leu Lys Val Met Xaa Met Val 
        355                 360                 365     


<210> 7543
<211> 280
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<400> 7543
Met Trp Xaa Pro Gly Gly Pro Pro Gly Ser Ala Gly Trp Asp Arg Arg 
1               5                   10                  15      


Arg Leu Gly Ala Arg Leu Arg Ala Ala Phe Ala Gly Leu Gln Glu Leu 
            20                  25                  30          


Gln Gly Leu Arg Ala Xaa Gln Gln Glu Arg Val Arg Gly Ala Leu Ala 
        35                  40                  45              


Leu Gln Pro Pro Pro Ala Pro Ala Ala Pro Cys Gly Pro His Gly Leu 
    50                  55                  60                  


His Gly Pro Glu Gln Gln Leu Glu Ala Ala Leu Ala Ala Leu Gln Glu 
65                  70                  75                  80  


Gln Leu Ser Arg Leu Arg Gln Gln Asp Ile Gly Leu Lys Xaa His Leu 
                85                  90                  95      


Asp Gln Leu Asp Leu Gln Ile Ser Lys Leu Gln Leu Asp Val Gly Xaa 
            100                 105                 110         


Ala Ser Gly Glu Ala Leu Asp Ser Asp Ser Arg Pro Ser Ser Gly Phe 
        115                 120                 125             


Tyr Glu Met Ser Asp Gly Gly Ser Cys Ser Leu Ser Xaa Ser Cys Ala 
    130                 135                 140                 


Ser Val Cys Ser Asp His Ile Ser Pro Ser Leu Gly Ser Leu Leu Pro 
145                 150                 155                 160 


Val Ala Gln Ala His Lys Ala Arg Pro Ser Met Gly Asp Trp Arg Pro 
                165                 170                 175     


Arg Ser Val Asp Glu Xaa Xaa Val Pro Ala Trp Arg Pro Gln Ala Xaa 
            180                 185                 190         


Glu Glu Gly Ala Arg Pro Pro Gly Ser Val Glu Asp Ala Gly Gln Pro 
        195                 200                 205             


Trp Gly Xaa Phe Trp Pro Arg Pro Val Ser Xaa Glu Leu Cys Asn Ala 
    210                 215                 220                 


Pro Gly Glu Leu Asp Met His Ala Pro Pro Ala Gly Cys Xaa Ser Ser 
225                 230                 235                 240 


Ser Leu Xaa Gly Val Gly Ser Gly Leu Arg Gly Lys Cys Gly Leu Cys 
                245                 250                 255     


Gly Cys Gln Leu Pro Phe Cys Ser Val Asn Xaa Ser Ser Lys Xaa Lys 
            260                 265                 270         


Ser Ser Gly Ile Ser Arg Gln Gln 
        275                 280 


<210> 7544
<211> 774
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (219)..(219)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (230)..(230)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (449)..(449)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (565)..(565)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (657)..(657)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(691)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (772)..(772)
<223> Selenocysteine

<400> 7544
Met Trp Xaa Pro Gly Gly Pro Pro Gly Ser Ala Gly Trp Asp Arg Arg 
1               5                   10                  15      


Arg Leu Gly Ala Arg Leu Arg Ala Ala Phe Ala Gly Leu Gln Glu Leu 
            20                  25                  30          


Gln Gly Leu Arg Ala Xaa Gln Gln Glu Arg Val Arg Gly Ala Leu Ala 
        35                  40                  45              


Leu Gln Pro Pro Pro Ala Pro Ala Ala Pro Cys Gly Pro His Gly Leu 
    50                  55                  60                  


His Gly Pro Glu Gln Gln Leu Glu Ala Ala Leu Ala Ala Leu Gln Glu 
65                  70                  75                  80  


Gln Leu Ser Arg Leu Arg Gln Gln Asp Ile Gly Leu Lys Xaa His Leu 
                85                  90                  95      


Asp Gln Leu Asp Leu Gln Ile Ser Lys Leu Gln Leu Asp Val Gly Xaa 
            100                 105                 110         


Ala Ser Gly Glu Ala Leu Asp Ser Asp Ser Arg Pro Ser Ser Gly Phe 
        115                 120                 125             


Tyr Glu Met Ser Asp Gly Gly Ser Cys Ser Leu Ser Xaa Ser Cys Ala 
    130                 135                 140                 


Ser Val Cys Ser Asp His Ile Ser Pro Ser Leu Gly Ser Leu Leu Pro 
145                 150                 155                 160 


Val Ala Gln Ala His Lys Ala Arg Pro Ser Met Gly Asp Trp Arg Pro 
                165                 170                 175     


Arg Ser Val Asp Glu Xaa Xaa Val Pro Ala Trp Arg Pro Gln Ala Xaa 
            180                 185                 190         


Glu Glu Gly Ala Arg Pro Pro Gly Ser Val Glu Asp Ala Gly Gln Pro 
        195                 200                 205             


Trp Gly Xaa Phe Trp Pro Arg Pro Val Ser Xaa Gly Asp Leu Asp Arg 
    210                 215                 220                 


Ala Leu Pro Ala Asp Xaa Gly Leu Gln Lys Ala Ser Ala Asp Ala Glu 
225                 230                 235                 240 


Leu Leu Gly Leu Leu Cys Gln Gly Val Asp Ile Pro Leu His Val Pro 
                245                 250                 255     


Asp Pro Lys Tyr Arg Gln Asp Leu Val Ser Gln Gly Gly Arg Glu Val 
            260                 265                 270         


Tyr Pro Tyr Pro Ser Pro Leu His Ala Val Ala Leu Gln Ser Pro Leu 
        275                 280                 285             


Phe Val Leu Xaa Lys Glu Xaa Pro Gln Arg Gly Gly Pro Ser Phe Pro 
    290                 295                 300                 


Arg Glu Ser Pro Arg Gly Pro Ala Gly Leu Asn Xaa Ile Gln Xaa Gly 
305                 310                 315                 320 


Pro Val Leu Glu Ala Gly Pro Ala Arg Ala Arg Ala Tyr Ile Asp Arg 
                325                 330                 335     


Leu Leu His Leu Trp Gly Arg Glu Xaa Pro Ala Lys Gly Ser Glu Gly 
            340                 345                 350         


Glu Gln Gly Pro Leu Arg His Ala Ala Ser Pro Ser Pro Gln Arg Gln 
        355                 360                 365             


Gly Gly Trp Ser Xaa Asp Gly Gly Gly Arg Leu Leu Val Phe Ala Pro 
    370                 375                 380                 


Gly Arg Glu Asp Glu Gly Gly Pro Ala Gln Ser Arg Gly Ala Gly Arg 
385                 390                 395                 400 


Gly Gly Pro Gln Gln Gln Gly Tyr Met Pro Leu Glu Gly Pro Gln Gln 
                405                 410                 415     


Ser Gly Ser Leu Pro Glu Glu Gly Ser Lys Pro Ser Asn Ser Cys Val 
            420                 425                 430         


Leu Arg Glu Xaa Met Val Gln Ala Ser Pro Ser Ser Lys Ala Gln Gln 
        435                 440                 445             


Xaa Pro Ser Ala Gln Asp Tyr Gly Arg Gly Asn Ile Ile Ser Pro Ser 
    450                 455                 460                 


Arg Met Leu Asp Lys Ser Pro Ser Pro Ala Ser Gly His Phe Ala His 
465                 470                 475                 480 


Pro Ser Phe Ala Ala Ser Leu Lys Met Gly Pro Pro Lys Ser Lys Ala 
                485                 490                 495     


Glu Lys Ile Lys Arg Ser Pro Met Asp Lys Val Leu Arg Phe Ala Arg 
            500                 505                 510         


Gln Pro Leu Leu Leu Leu Asp Arg Pro Glu Gly Ala His Ala Ala Pro 
        515                 520                 525             


Gln Pro Ser Leu Glu Trp Asp Pro Ala His Trp Pro Xaa Gly Arg Gly 
    530                 535                 540                 


Gly Leu Gln Arg Arg Pro Ala Leu Ala Trp Glu Ala Pro Gly Arg Ser 
545                 550                 555                 560 


Cys Ser Glu Ser Xaa Leu Tyr Pro Met Pro Val Leu Val Pro Leu Ala 
                565                 570                 575     


Val Ala Pro Gln Glu Ser His Arg Xaa Ser Ala Gln Ala Leu Phe Pro 
            580                 585                 590         


Phe Glu Ala Ser Leu Leu Xaa Ser Val Ala Arg Arg Lys His Arg Arg 
        595                 600                 605             


Trp Gln Ser Xaa Val Glu Ile Ser Ala Arg Ala Arg Leu Ala Ser Cys 
    610                 615                 620                 


Pro Glu Ser Asn Leu Gly Pro Pro Arg Pro Val Ala Arg Arg Ala Gly 
625                 630                 635                 640 


Gly Pro Leu Ala Arg Gly Arg Pro Ser Leu Val Arg Gln Asp Ala Tyr 
                645                 650                 655     


Xaa Arg Ser Asp Ser Glu Pro Ser Lys His Ser Ala Glu Cys Asp Pro 
            660                 665                 670         


Arg Phe Pro Ser Val Ile Pro Glu Xaa Ser Glu Gly Glu Ser Ser Asp 
        675                 680                 685             


His Xaa Xaa Asn Arg Phe Gly Asp Arg Glu Ser Ser Ser Ser Asp Glu 
    690                 695                 700                 


Glu Gly Gly Ala Gln Ser Arg Asp Cys Asp Leu Ala Leu Gly Tyr Val 
705                 710                 715                 720 


Ala Ala Gly His Ala Glu Leu Ala Trp Xaa Gln Glu Ala Pro Val Ser 
                725                 730                 735     


Ser Gly Pro Leu Leu Ser Pro Val Pro Lys Leu Cys Arg Ile Lys Ala 
            740                 745                 750         


Ser Lys Ala Leu Lys Lys Lys Ile Arg Arg Phe Gln Pro Xaa Ala Leu 
        755                 760                 765             


Lys Val Met Xaa Met Val 
    770                 


<210> 7545
<211> 629
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (383)..(383)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (583)..(583)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (627)..(628)
<223> Selenocysteine

<400> 7545
Met Ile Arg Ala Phe Ser Phe Pro Val Ser Pro Glu Arg Gly Arg Leu 
1               5                   10                  15      


Arg Gly Trp Leu Glu Gly Ser Leu Ala Gly Leu Cys Glu Leu His Trp 
            20                  25                  30          


Leu Arg Glu Arg Gln Glu Tyr Arg Val Gln Gln Ala Leu Arg Leu Ala 
        35                  40                  45              


Gln Pro Gly Met Gly Gly Ala Glu Ala Glu Asp Glu Glu Asp Ala Asp 
    50                  55                  60                  


Glu Asp Glu Asp Ala Ala Ala Ala Arg Arg Ala Ala Ala Ala Leu Glu 
65                  70                  75                  80  


Glu Gln Leu Glu Ala Leu Pro Gly Leu Val Trp Asp Leu Gly Gln Gln 
                85                  90                  95      


Leu Gly Asp Leu Ser Leu Glu Ser Gly Gly Leu Glu Gln Glu Ser Gly 
            100                 105                 110         


Arg Ser Ser Gly Phe Tyr Glu Asp Pro Ser Ser Xaa Gly Gly Pro Asp 
        115                 120                 125             


Ser Pro Pro Ser Xaa Phe Cys Gly Asp Ser Gly Phe Ser Gly Ser Ser 
    130                 135                 140                 


Ser Tyr Gly Arg Leu Gly Pro Ser Glu Pro Arg Gly Ile Tyr Ala Ser 
145                 150                 155                 160 


Glu Arg Pro Lys Ser Leu Gly Asp Ala Ser Pro Ser Ala Pro Glu Val 
                165                 170                 175     


Val Gly Ala Arg Ala Ala Val Pro Arg Ser Phe Ser Ala Pro Tyr Pro 
            180                 185                 190         


Xaa Ala Gly Gly Ser Ala Gly Pro Glu Ala Cys Ser Ser Ala Glu Arg 
        195                 200                 205             


Arg Ala Arg Ala Gly Pro Phe Leu Xaa Pro Ser Pro Leu His Ala Val 
    210                 215                 220                 


Ala Met Arg Ser Pro Arg Pro Cys Gly Arg Pro Pro Xaa Asp Ser Pro 
225                 230                 235                 240 


Asp Ala Gly Gly Ala Gly Arg Pro Leu Asp Gly Tyr Ile Ser Ala Leu 
                245                 250                 255     


Leu Arg Arg Arg Arg Arg Arg Gly Ala Gly Gln Pro Arg Xaa Ser Pro 
            260                 265                 270         


Gly Gly Ala Asp Gly Gly Pro Arg Arg Gln Asn Ser Val Arg Gln Arg 
        275                 280                 285             


Pro Pro Asp Ala Ser Pro Ser Pro Gly Ser Ala Arg Pro Ala Arg Glu 
    290                 295                 300                 


Pro Ser Leu Glu Arg Val Gly Gly His Pro Xaa Ser Pro Ala Ala Leu 
305                 310                 315                 320 


Ser Arg Ala Trp Ala Ser Ser Trp Glu Ser Glu Ala Ala Pro Glu Pro 
                325                 330                 335     


Ala Ala Pro Pro Ala Ala Pro Ser Pro Pro Asp Ser Pro Ala Glu Gly 
            340                 345                 350         


Arg Leu Val Lys Ala Gln Tyr Ile Pro Gly Ala Gln Ala Ala Xaa Arg 
        355                 360                 365             


Gly Leu Pro Gly Arg Ala Ala Arg Arg Lys Pro Pro Pro Leu Xaa Arg 
    370                 375                 380                 


Gly Arg Ser Val Glu Gln Ser Pro Pro Arg Glu Arg Pro Arg Ala Ala 
385                 390                 395                 400 


Gly Arg Arg Gly Arg Met Ala Glu Ala Ser Gly Arg Arg Gly Ser Pro 
                405                 410                 415     


Arg Ala Arg Lys Ala Ser Arg Ser Gln Ser Glu Xaa Ser Leu Leu Gly 
            420                 425                 430         


Arg Ala Ser Ala Val Pro Ser Gly Pro Pro Lys Tyr Pro Xaa Ala Glu 
        435                 440                 445             


Arg Glu Glu Pro Arg Pro Pro Arg Pro Arg Arg Gly Pro Ala Pro Xaa 
    450                 455                 460                 


Leu Ala Ala Gln Ala Ala Gly Ser Cys Arg Arg Trp Arg Ser Xaa Ala 
465                 470                 475                 480 


Glu Ile Asp Ala Ala Asp Gly Arg Arg Val Arg Pro Arg Ala Pro Ala 
                485                 490                 495     


Ala Arg Val Pro Gly Pro Gly Pro Ser Pro Ser Ala Pro Gln Arg Arg 
            500                 505                 510         


Leu Leu Tyr Gly Cys Ala Gly Ser Asp Ser Glu Cys Ser Ala Gly Arg 
        515                 520                 525             


Leu Gly Pro Leu Gly Arg Arg Gly Pro Ala Gly Gly Val Gly Gly Gly 
    530                 535                 540                 


Tyr Gly Glu Ser Glu Ser Ser Ala Ser Glu Gly Glu Ser Pro Ala Phe 
545                 550                 555                 560 


Ser Ser Ala Ser Ser Asp Ser Asp Gly Ser Gly Gly Leu Val Trp Pro 
                565                 570                 575     


Gln Gln Leu Val Ala Ala Xaa Ala Ala Ser Gly Gly Gly Ala Gly Ala 
            580                 585                 590         


Gly Ala Pro Ala Gly Pro Ala Lys Val Phe Val Lys Ile Lys Ala Ser 
        595                 600                 605             


His Ala Leu Lys Lys Lys Ile Leu Arg Phe Arg Ser Gly Ser Leu Lys 
    610                 615                 620                 


Val Met Xaa Xaa Val 
625                 


<210> 7546
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<400> 7546
Met Ile Arg Ala Phe Ser Phe Pro Val Ser Pro Glu Arg Gly Arg Leu 
1               5                   10                  15      


Arg Gly Trp Leu Glu Gly Ser Leu Ala Gly Leu Cys Glu Leu His Trp 
            20                  25                  30          


Leu Arg Glu Arg Gln Glu Tyr Arg Val Gln Gln Ala Leu Arg Leu Ala 
        35                  40                  45              


Gln Pro Gly Met Gly Gly Ala Glu Ala Glu Asp Glu Glu Asp Ala Asp 
    50                  55                  60                  


Glu Asp Glu Asp Ala Ala Ala Ala Arg Arg Ala Ala Ala Ala Leu Glu 
65                  70                  75                  80  


Glu Gln Leu Glu Ala Leu Pro Gly Leu Val Trp Asp Leu Gly Gln Gln 
                85                  90                  95      


Leu Gly Asp Leu Ser Leu Glu Ser Gly Gly Leu Glu Gln Glu Ser Gly 
            100                 105                 110         


Arg Ser Ser Gly Phe Tyr Glu Asp Pro Ser Ser Xaa Gly Gly Pro Asp 
        115                 120                 125             


Ser Pro Pro Ser Xaa Phe Cys Gly Asp Ser Gly Phe Ser Gly Ser Ser 
    130                 135                 140                 


Ser Tyr Gly Arg Leu Gly Pro Ser Glu Pro Arg Gly Ile Tyr Ala Ser 
145                 150                 155                 160 


Glu Arg Pro Lys Ser Leu Gly Lys Val Gly Glu Gly Gly Ala Leu Gly 
                165                 170                 175     


Pro Gly Lys Gly Gln 
            180     


<210> 7547
<211> 404
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (402)..(403)
<223> Selenocysteine

<400> 7547
Met Arg Ser Pro Arg Pro Cys Gly Arg Pro Pro Xaa Asp Ser Pro Asp 
1               5                   10                  15      


Ala Gly Gly Ala Gly Arg Pro Leu Asp Gly Tyr Ile Ser Ala Leu Leu 
            20                  25                  30          


Arg Arg Arg Arg Arg Arg Gly Ala Gly Gln Pro Arg Xaa Ser Pro Gly 
        35                  40                  45              


Gly Ala Asp Gly Gly Pro Arg Arg Gln Asn Ser Val Arg Gln Arg Pro 
    50                  55                  60                  


Pro Asp Ala Ser Pro Ser Pro Gly Ser Ala Arg Pro Ala Arg Glu Pro 
65                  70                  75                  80  


Ser Leu Glu Arg Val Gly Gly His Pro Xaa Ser Pro Ala Ala Leu Ser 
                85                  90                  95      


Arg Ala Trp Ala Ser Ser Trp Glu Ser Glu Ala Ala Pro Glu Pro Ala 
            100                 105                 110         


Ala Pro Pro Ala Ala Pro Ser Pro Pro Asp Ser Pro Ala Glu Gly Arg 
        115                 120                 125             


Leu Val Lys Ala Gln Tyr Ile Pro Gly Ala Gln Ala Ala Xaa Arg Gly 
    130                 135                 140                 


Leu Pro Gly Arg Ala Ala Arg Arg Lys Pro Pro Pro Leu Xaa Arg Gly 
145                 150                 155                 160 


Arg Ser Val Glu Gln Ser Pro Pro Arg Glu Arg Pro Arg Ala Ala Gly 
                165                 170                 175     


Arg Arg Gly Arg Met Ala Glu Ala Ser Gly Arg Arg Gly Ser Pro Arg 
            180                 185                 190         


Ala Arg Lys Ala Ser Arg Ser Gln Ser Glu Xaa Ser Leu Leu Gly Arg 
        195                 200                 205             


Ala Ser Ala Val Pro Ser Gly Pro Pro Lys Tyr Pro Xaa Ala Glu Arg 
    210                 215                 220                 


Glu Glu Pro Arg Pro Pro Arg Pro Arg Arg Gly Pro Ala Pro Xaa Leu 
225                 230                 235                 240 


Ala Ala Gln Ala Ala Gly Ser Cys Arg Arg Trp Arg Ser Xaa Ala Glu 
                245                 250                 255     


Ile Asp Ala Ala Asp Gly Arg Arg Val Arg Pro Arg Ala Pro Ala Ala 
            260                 265                 270         


Arg Val Pro Gly Pro Gly Pro Ser Pro Ser Ala Pro Gln Arg Arg Leu 
        275                 280                 285             


Leu Tyr Gly Cys Ala Gly Ser Asp Ser Glu Cys Ser Ala Gly Arg Leu 
    290                 295                 300                 


Gly Pro Leu Gly Arg Arg Gly Pro Ala Gly Gly Val Gly Gly Gly Tyr 
305                 310                 315                 320 


Gly Glu Ser Glu Ser Ser Ala Ser Glu Gly Glu Ser Pro Ala Phe Ser 
                325                 330                 335     


Ser Ala Ser Ser Asp Ser Asp Gly Ser Gly Gly Leu Val Trp Pro Gln 
            340                 345                 350         


Gln Leu Val Ala Ala Xaa Ala Ala Ser Gly Gly Gly Ala Gly Ala Gly 
        355                 360                 365             


Ala Pro Ala Gly Pro Ala Lys Val Phe Val Lys Ile Lys Ala Ser His 
    370                 375                 380                 


Ala Leu Lys Lys Lys Ile Leu Arg Phe Arg Ser Gly Ser Leu Lys Val 
385                 390                 395                 400 


Met Xaa Xaa Val 
                


<210> 7548
<211> 9
<212> PRT
<213> Homo sapiens

<400> 7548
Met Arg Met Ser Val Gly Leu Ser Leu 
1               5                   


<210> 7549
<211> 15
<212> PRT
<213> Homo sapiens

<400> 7549
Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly 
1               5                   10                  15  


<210> 7550
<211> 41
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<400> 7550
Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Xaa Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp 
        35                  40      


<210> 7551
<211> 52
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<400> 7551
Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Xaa Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser 
    50          


<210> 7552
<211> 86
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<400> 7552
Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Xaa Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Xaa Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Xaa Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Xaa Ile Pro Xaa Asp Leu 
                85      


<210> 7553
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<400> 7553
Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Xaa Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Xaa Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Xaa Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Xaa Ile Pro Xaa Asp Leu Ile Ala 
                85              


<210> 7554
<211> 96
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<400> 7554
Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Xaa Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Xaa Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Xaa Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Xaa Ile Pro Xaa Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


<210> 7555
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<400> 7555
Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Xaa Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Xaa Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Xaa Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Xaa Ile Pro Xaa Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser 
            100                 105     


<210> 7556
<211> 117
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<400> 7556
Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Xaa Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Xaa Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Xaa Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Xaa Ile Pro Xaa Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser 
            100                 105                 110         


Gln Ser His Xaa Leu 
        115         


<210> 7557
<211> 895
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (189)..(189)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (319)..(319)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (379)..(379)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (381)..(381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(396)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (414)..(414)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (421)..(424)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (431)..(431)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (436)..(436)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(446)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (450)..(450)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (455)..(455)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (463)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (473)..(473)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (482)..(484)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(531)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (537)..(537)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (646)..(646)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (660)..(660)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (734)..(734)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (753)..(753)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (790)..(790)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (839)..(840)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (851)..(851)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (884)..(884)
<223> Selenocysteine

<400> 7557
Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Xaa Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Xaa Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Xaa Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Xaa Ile Pro Xaa Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser 
            100                 105                 110         


Gln Ser His Xaa Leu Glu Gly Leu Pro Leu Asp Xaa Asp Lys Gly Val 
        115                 120                 125             


His Tyr Ile Ser Val Ser Ala Xaa Arg Leu Gly Ala Asn Gly Ser His 
    130                 135                 140                 


Ile Pro Gln Xaa Ser Ser Val Phe Ser Ile Glu Val Tyr Pro Glu Asp 
145                 150                 155                 160 


His Ser Glu Leu Gln Ser Val Arg Xaa Ala Ser Pro Asp Pro Gly Glu 
                165                 170                 175     


Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro Val Xaa Val Leu Xaa 
            180                 185                 190         


Val Ile Leu Asp Ala Asp Leu Xaa Lys Met Xaa Pro Lys Gln Arg Ile 
        195                 200                 205             


Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu Val Glu Leu His Asn 
    210                 215                 220                 


Met Lys Leu Val Pro Val Val Asn Asn Arg Leu Phe Asp Met Ser Ala 
225                 230                 235                 240 


Phe Met Ala Gly Pro Gly Asn Ala Lys Lys Val Val Glu Asn Gly Ala 
                245                 250                 255     


Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn Gln Asn Ser Val Pro 
            260                 265                 270         


Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu Gly Ala Met Ser Ala 
        275                 280                 285             


Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile Ala Asn Lys Lys Pro 
    290                 295                 300                 


Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His Ala Xaa Pro Xaa Pro 
305                 310                 315                 320 


Val Xaa Ala Ile Gly Pro Pro Xaa Xaa Ala Ile Gln Glu Pro Pro Ser 
                325                 330                 335     


Arg Ile Val Pro Xaa Pro Xaa Ser Pro Ala Ile Ala Pro Pro Xaa Glu 
            340                 345                 350         


Xaa Met Ala Pro Pro Val Arg Asp Pro Val Pro Gly Lys Pro Xaa Val 
        355                 360                 365             


Xaa Ile Arg Xaa Arg Gly Ala Ile Ile Gln Xaa Pro Xaa Leu Gly Pro 
    370                 375                 380                 


Ile Gln Pro Xaa Arg Val Ser Glu Ala Gly Xaa Xaa Val Pro Gly Gln 
385                 390                 395                 400 


Ile Arg Pro Xaa Met Xaa Ile Pro Gly Tyr Val Glu Pro Xaa Ala Val 
                405                 410                 415     


Ala Xaa Pro Pro Xaa Xaa Xaa Xaa Lys Lys Pro Arg Val Ser Xaa Pro 
            420                 425                 430         


Lys Pro Ala Xaa Pro Ser Xaa Asp Ser Xaa Xaa Xaa Xaa Xaa Arg Arg 
        435                 440                 445             


Pro Xaa Lys Lys Pro Arg Xaa Pro Arg Pro Val Pro Arg Val Xaa Xaa 
    450                 455                 460                 


Lys Val Ser Ile Xaa Arg Leu Glu Xaa Ala Ser Pro Pro Xaa Arg Ile 
465                 470                 475                 480 


Arg Xaa Xaa Xaa Ser Gly Val Pro Arg Gly Gly Glu Pro Asn Gln Arg 
                485                 490                 495     


Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp Ala Trp Val Gly Xaa 
            500                 505                 510         


Tyr Phe Glu Val Lys Ile Pro Ser Asp Xaa Phe Tyr Asp His Glu Asp 
        515                 520                 525             


Xaa Xaa Xaa Asp Lys Leu Lys Leu Xaa Leu Lys Leu Arg Glu Gln Gln 
    530                 535                 540                 


Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn Ser Asn Ser Gln Leu 
545                 550                 555                 560 


Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly Lys His Glu Tyr Phe 
                565                 570                 575     


Met His Ala Xaa Asp Lys Gly Gly Leu Ser Ala Val Asp Ala Phe Glu 
            580                 585                 590         


Ile His Val His Arg Arg Pro Gln Gly Asp Arg Ala Pro Ala Arg Phe 
        595                 600                 605             


Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val Leu Asn Asp Ile His 
    610                 615                 620                 


Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe Ala Phe Gly Asp Arg 
625                 630                 635                 640 


Asn Cys Ser Xaa Ile Xaa Leu Gln Asn Ile Xaa Arg Gly Ser Ile Val 
                645                 650                 655     


Val Glu Trp Xaa Asn Asn Xaa Leu Pro Leu Glu Pro Cys Pro Lys Glu 
            660                 665                 670         


Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu Asp Asp Gly Lys Pro 
        675                 680                 685             


Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp Phe Lys Ala Xaa Ser 
    690                 695                 700                 


Ile Xaa Val Xaa Gly Ser Gly Ser Cys Arg His Leu Gln Phe Ile Pro 
705                 710                 715                 720 


Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala Pro Pro Xaa Glu Val 
                725                 730                 735     


Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp Asp Val Tyr Leu His 
            740                 745                 750         


Xaa Val Ile Pro Ala Val Val Val Ala Ala Ile Leu Leu Ile Ala Gly 
        755                 760                 765             


Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg Lys Gly Lys Leu Xaa 
    770                 775                 780                 


Leu Glu Asp Gln Ala Xaa Phe Ile Lys Lys Gly Val Pro Ile Ile Phe 
785                 790                 795                 800 


Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro Ser Ser Ser Met Pro 
                805                 810                 815     


Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro Pro Pro Glu Tyr Pro 
            820                 825                 830         


Asn Gln Ser Val Pro Glu Xaa Xaa Pro Leu Asn Gln Asp Xaa Met Gly 
        835                 840                 845             


Glu Tyr Xaa Pro Leu Arg Asp Glu Asp Pro Asn Ala Pro Pro Tyr Gln 
    850                 855                 860                 


Pro Pro Pro Pro Phe Xaa Ala Pro Met Glu Gly Lys Gly Ser Arg Pro 
865                 870                 875                 880 


Lys Asn Met Xaa Pro Tyr Arg Ser Pro Pro Pro Tyr Val Pro Pro 
                885                 890                 895 


<210> 7558
<211> 167
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<400> 7558
Met Pro Gly Ile Val Val Phe Arg Arg Arg Trp Ser Val Gly Ser Asp 
1               5                   10                  15      


Asp Leu Val Leu Pro Ala Ile Phe Leu Phe Leu Leu His Xaa Xaa Trp 
            20                  25                  30          


Phe Val Ile Leu Ser Val Val Leu Phe Gly Leu Val Tyr Asn Pro His 
        35                  40                  45              


Glu Ala Cys Ser Leu Asn Leu Val Asp His Gly Arg Gly Tyr Leu Gly 
    50                  55                  60                  


Ile Leu Leu Ser Cys Met Ile Ala Glu Met Ala Ile Ile Trp Leu Ser 
65                  70                  75                  80  


Met Arg Gly Gly Ile Leu Tyr Xaa Glu Pro Arg Asp Ser Met His His 
                85                  90                  95      


Pro Gly Asp Arg Val His Leu Arg His Arg Gly His Arg Leu Ala His 
            100                 105                 110         


Ser Val Leu His Leu Leu Gln Arg Pro His Cys Gln Glu Cys His Pro 
        115                 120                 125             


Arg Asn Gly Cys Leu Gln Leu Gly Ser His Pro Gln Cys Val His His 
    130                 135                 140                 


Cys Pro Leu Arg Leu Arg Pro His Gly Pro His Leu Cys Gln Ala Glu 
145                 150                 155                 160 


Ser His Gln Glu Glu Ala Ala 
                165         


<210> 7559
<211> 1042
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (30)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (549)..(549)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (575)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (580)..(580)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (689)..(689)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (715)..(715)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (779)..(779)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (786)..(786)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (838)..(838)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (853)..(853)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1006)..(1006)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1021)..(1021)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1023)..(1023)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<400> 7559
Met Pro Gly Ile Val Val Phe Arg Arg Arg Trp Ser Val Gly Ser Asp 
1               5                   10                  15      


Asp Leu Val Leu Pro Ala Ile Phe Leu Phe Leu Leu His Xaa Xaa Trp 
            20                  25                  30          


Phe Val Ile Leu Ser Val Val Leu Phe Gly Leu Val Tyr Asn Pro His 
        35                  40                  45              


Glu Ala Cys Ser Leu Asn Leu Val Asp His Gly Arg Gly Tyr Leu Gly 
    50                  55                  60                  


Ile Leu Leu Ser Cys Met Ile Ala Glu Met Ala Ile Ile Trp Leu Ser 
65                  70                  75                  80  


Met Arg Gly Gly Ile Leu Tyr Xaa Glu Pro Arg Asp Ser Met Gln Tyr 
                85                  90                  95      


Val Leu Tyr Val Arg Leu Ala Ile Leu Val Ile Glu Phe Ile Tyr Ala 
            100                 105                 110         


Ile Val Gly Ile Val Trp Leu Xaa Gln Tyr Tyr Xaa Ser Cys Asn Asp 
        115                 120                 125             


Leu Xaa Ala Lys Asn Val Xaa Leu Gly Met Val Val Cys Asn Trp Val 
    130                 135                 140                 


Val Ile Leu Ser Val Cys Ile Xaa Val Leu Cys Val Phe Asp Pro Xaa 
145                 150                 155                 160 


Gly Arg Xaa Phe Val Lys Leu Arg Ala Xaa Lys Arg Arg Gln Arg Asn 
                165                 170                 175     


Leu Arg Xaa Tyr Asn Leu Arg His Arg Leu Glu Glu Gly Gln Ala Xaa 
            180                 185                 190         


Ser Trp Ser Arg Arg Leu Lys Val Phe Leu Cys Cys Xaa Arg Xaa Lys 
        195                 200                 205             


Asp Ser Gln Ser Asp Ala Tyr Ser Glu Ile Ala Tyr Leu Phe Ala Glu 
    210                 215                 220                 


Phe Phe Arg Asp Leu Asp Ile Val Pro Ser Asp Ile Ile Ala Gly Leu 
225                 230                 235                 240 


Val Leu Leu Arg Gln Arg Gln Arg Ala Lys Arg Asn Ala Val Leu Asp 
                245                 250                 255     


Glu Ala Asn Asn Asp Ile Leu Ala Phe Leu Ser Gly Met Pro Val Xaa 
            260                 265                 270         


Arg Asn Xaa Lys Tyr Leu Asp Leu Lys Asn Ser Gln Glu Met Leu Arg 
        275                 280                 285             


Tyr Lys Glu Val Cys Tyr Tyr Met Leu Phe Ala Leu Ala Ala Tyr Gly 
    290                 295                 300                 


Trp Pro Met Tyr Leu Met Arg Lys Pro Ala Cys Gly Leu Cys Gln Leu 
305                 310                 315                 320 


Ala Arg Ser Cys Ser Cys Cys Leu Cys Pro Ala Arg Pro Arg Phe Ala 
                325                 330                 335     


Pro Gly Val Xaa Ile Glu Glu Asp Asn Cys Cys Gly Cys Asn Ala Ile 
            340                 345                 350         


Ala Ile Arg Arg His Phe Leu Asp Glu Asn Met Xaa Ala Val Asp Ile 
        355                 360                 365             


Val Tyr Xaa Ser Cys His Asp Ala Val Tyr Glu Xaa Pro Phe Tyr Val 
    370                 375                 380                 


Ala Val Asp His Asp Lys Lys Lys Val Val Ile Ser Ile Arg Gly Xaa 
385                 390                 395                 400 


Leu Ser Pro Lys Asp Ala Leu Xaa Asp Leu Xaa Gly Asp Ala Glu Arg 
                405                 410                 415     


Leu Pro Val Glu Gly His His Gly Xaa Trp Leu Gly His Lys Gly Met 
            420                 425                 430         


Val Leu Ser Ala Glu Tyr Ile Lys Lys Lys Leu Glu Gln Glu Met Val 
        435                 440                 445             


Leu Ser Gln Ala Phe Gly Arg Asp Leu Gly Arg Gly Xaa Lys His Tyr 
    450                 455                 460                 


Gly Leu Ile Val Val Gly His Ser Leu Gly Ala Gly Xaa Ala Ala Ile 
465                 470                 475                 480 


Leu Ser Phe Leu Leu Arg Pro Gln Tyr Pro Xaa Leu Lys Cys Phe Ala 
                485                 490                 495     


Tyr Ser Pro Pro Gly Gly Leu Leu Ser Glu Asp Ala Met Glu Tyr Ser 
            500                 505                 510         


Lys Glu Phe Val Xaa Ala Val Val Leu Gly Lys Asp Leu Val Pro Arg 
        515                 520                 525             


Ile Gly Leu Ser Gln Leu Glu Gly Phe Arg Arg Gln Leu Leu Asp Val 
    530                 535                 540                 


Leu Gln Arg Ser Xaa Lys Pro Lys Trp Arg Ile Ile Val Gly Ala Xaa 
545                 550                 555                 560 


Lys Cys Ile Pro Lys Ser Glu Leu Pro Glu Glu Val Glu Val Xaa Xaa 
                565                 570                 575     


Leu Ala Ser Xaa Arg Leu Trp Xaa His Pro Ser Asp Leu Xaa Ile Ala 
            580                 585                 590         


Leu Ser Ala Ser Xaa Pro Leu Tyr Pro Pro Gly Arg Ile Ile His Val 
        595                 600                 605             


Val His Asn His Pro Ala Glu Gln Cys Cys Cys Cys Glu Gln Glu Glu 
    610                 615                 620                 


Pro Xaa Tyr Phe Ala Ile Trp Gly Asp Asn Lys Ala Phe Asn Glu Val 
625                 630                 635                 640 


Ile Ile Ser Pro Ala Met Leu His Glu His Leu Pro Tyr Val Val Met 
                645                 650                 655     


Glu Gly Leu Asn Lys Val Leu Glu Asn Tyr Asn Lys Gly Lys Xaa Ala 
            660                 665                 670         


Leu Leu Ser Ala Ala Lys Val Met Val Ser Pro Xaa Glu Val Asp Leu 
        675                 680                 685             


Xaa Pro Glu Leu Ile Phe Gln Gln Gln Pro Leu Pro Xaa Gly Pro Pro 
    690                 695                 700                 


Met Pro Xaa Gly Leu Ala Leu Glu Leu Pro Xaa Ala Asp His Arg Asn 
705                 710                 715                 720 


Ser Ser Val Arg Ser Lys Ser Gln Ser Glu Met Ser Leu Glu Gly Phe 
                725                 730                 735     


Ser Glu Gly Arg Leu Leu Ser Pro Val Val Ala Ala Ala Ala Arg Gln 
            740                 745                 750         


Asp Pro Val Glu Leu Leu Leu Leu Ser Xaa Gln Glu Arg Leu Ala Ala 
        755                 760                 765             


Glu Leu Gln Ala Arg Arg Ala Pro Leu Ala Xaa Met Glu Ser Leu Ser 
    770                 775                 780                 


Asp Xaa Glu Ser Leu Tyr Ser Phe Asp Ser Arg Arg Ser Ser Gly Phe 
785                 790                 795                 800 


Arg Ser Ile Arg Gly Ser Pro Ser Leu His Ala Val Leu Glu Arg Asp 
                805                 810                 815     


Glu Gly His Leu Phe Tyr Ile Asp Pro Ala Ile Pro Glu Glu Asn Pro 
            820                 825                 830         


Ser Leu Ser Ser Arg Xaa Glu Leu Leu Ala Ala Asp Ser Leu Ser Lys 
        835                 840                 845             


His Ser Gln Asp Xaa Gln Pro Leu Glu Ala Ala Leu Gly Ser Gly Gly 
    850                 855                 860                 


Val Xaa Pro Glu Arg Pro Pro Ser Ala Ala Ala Asn Asp Glu Glu Glu 
865                 870                 875                 880 


Glu Val Gly Gly Gly Gly Gly Gly Pro Ala Ser Arg Gly Glu Leu Ala 
                885                 890                 895     


Leu His Asn Gly Arg Leu Gly Asp Ser Pro Ser Pro Gln Val Leu Glu 
            900                 905                 910         


Phe Ala Glu Phe Ile Asp Ser Leu Phe Asn Leu Asp Ser Lys Ser Ser 
        915                 920                 925             


Ser Phe Gln Asp Leu Tyr Cys Met Val Val Pro Glu Ser Pro Xaa Ser 
    930                 935                 940                 


Asp Tyr Ala Glu Gly Pro Lys Ser Pro Ser Gln Gln Glu Ile Leu Leu 
945                 950                 955                 960 


Arg Ala Gln Phe Glu Pro Asn Leu Val Pro Lys Pro Pro Arg Leu Phe 
                965                 970                 975     


Ala Gly Ser Ala Asp Pro Ser Ser Gly Ile Ser Leu Ser Pro Ser Phe 
            980                 985                 990         


Pro Leu Ser Ser Ser Gly Glu Leu  Met Asp Leu Xaa Pro  Xaa Gly Leu 
        995                 1000                 1005             


Ser Ser  Gln Glu Cys Leu Ala  Ala Asp Lys Ile Arg  Xaa Ser Xaa 
    1010                 1015                 1020             


Pro Xaa  Gly His Gly Ala Ser  Pro Ala Lys Gln Asp  Glu Leu Val 
    1025                 1030                 1035             


Ile Ser  Ala Arg 
    1040         


<210> 7560
<211> 189
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (164)..(164)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<400> 7560
Met Leu Leu Gly Gln Leu Ser Xaa Leu Leu Cys Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Pro Xaa Gly Ser Gly Arg Pro Glu Pro Gln Ser Pro Arg Pro Gln 
            20                  25                  30          


Ser Trp Ala Ala Ala Asn Gln Xaa Trp Ala Leu Gly Pro Gly Ala Leu 
        35                  40                  45              


Pro Pro Leu Val Pro Ala Ser Ala Leu Gly Ser Trp Lys Ala Phe Leu 
    50                  55                  60                  


Gly Leu Gln Lys Ala Arg Gln Leu Gly Met Gly Arg Leu Gln Arg Gly 
65                  70                  75                  80  


Gln Asp Glu Val Ala Ala Val Xaa Leu Pro Leu Asn Pro Gln Glu Val 
                85                  90                  95      


Ile Gln Gly Met Cys Lys Ala Val Pro Phe Val Gln Val Phe Ser Arg 
            100                 105                 110         


Pro Gly Cys Ser Ala Ile Arg Leu Arg Asn His Leu Cys Phe Gly His 
        115                 120                 125             


Cys Ser Ser Leu Tyr Ile Pro Gly Ser Asp Pro Xaa Pro Leu Val Leu 
    130                 135                 140                 


Cys Asn Ser Cys Met Pro Ala Arg Lys Arg Trp Ala Pro Val Val Leu 
145                 150                 155                 160 


Trp Cys Leu Xaa Gly Ser Ser Ala Ser Arg Arg Arg Val Lys Ile Ser 
                165                 170                 175     


Xaa Met Leu Ile Glu Gly Cys His Cys Ser Pro Lys Ala 
            180                 185                 


<210> 7561
<211> 163
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<400> 7561
Met Pro Leu Xaa Arg Gln Gln Gly Arg Leu Leu Val Xaa Leu Ser Pro 
1               5                   10                  15      


Val Arg Xaa Asp Arg Gln Ala Asp Arg Arg Xaa Asp Lys Gln Met Leu 
            20                  25                  30          


Leu Gly Gln Leu Ser Xaa Leu Leu Cys Leu Leu Ser Gly Ala Leu Pro 
        35                  40                  45              


Xaa Gly Ser Gly Arg Pro Glu Pro Gln Ser Pro Arg Pro Gln Ser Trp 
    50                  55                  60                  


Ala Ala Ala Asn Gln Xaa Trp Ala Leu Gly Pro Gly Ala Leu Pro Pro 
65                  70                  75                  80  


Leu Val Pro Ala Ser Ala Leu Gly Ser Trp Lys Ala Phe Leu Gly Leu 
                85                  90                  95      


Gln Lys Ala Arg Gln Leu Gly Met Gly Arg Leu Gln Arg Gly Gln Asp 
            100                 105                 110         


Glu Val Ala Ala Val Xaa Leu Pro Leu Asn Pro Gln Glu Val Ile Gln 
        115                 120                 125             


Gly Met Cys Lys Ala Val Pro Phe Val Gln Xaa Arg Glu Ser Arg Tyr 
    130                 135                 140                 


Val Ala Gln Ala Ser Leu Glu Leu Leu Ala Ser Ser Asn Pro Pro Xaa 
145                 150                 155                 160 


Ser Ala Ser 
            


<210> 7562
<211> 204
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (82)..(82)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<400> 7562
Met Ser Ser Pro Pro Glu Gly Lys Leu Glu Xaa Lys Ala Gly His Pro 
1               5                   10                  15      


Pro Ala Val Lys Ala Gly Gly Met Arg Ile Val Gln Lys His Pro His 
            20                  25                  30          


Xaa Gly Asp Xaa Lys Glu Glu Lys Asp Lys Asp Asp Gln Glu Trp Glu 
        35                  40                  45              


Ser Pro Arg Val Xaa Lys Ile Ser Pro Arg Arg Leu Arg Arg Trp Leu 
    50                  55                  60                  


Xaa Arg Ser Arg Met Pro Pro Trp Xaa Ser Ile Leu Pro Gln Glu Pro 
65                  70                  75                  80  


Ser Xaa Ser Ser Ser His Ala Ser Glu Pro Gly Val His Gln Pro Ala 
                85                  90                  95      


Pro Trp Pro Arg Leu Cys Cys Xaa Trp Tyr Phe Pro Asp Arg Glu Asn 
            100                 105                 110         


Gln Gln Phe Arg Pro Asn Pro Xaa Leu Leu Gly Asn Leu Arg Gln Asn 
        115                 120                 125             


Gln Val Leu Cys Pro Leu Pro Tyr Ile Ser Ile Phe Lys Xaa Arg Asn 
    130                 135                 140                 


Ser Ser Ser Pro Asn Leu Val Tyr Gly Glu Ser Gly Trp Met Ser Phe 
145                 150                 155                 160 


Glu Asp His Cys Ala Pro Arg Gly Ala Ile Ser Arg Ile Cys Gln Asp 
                165                 170                 175     


Pro Arg Lys Ile Leu Ala Leu Val Leu Phe Gln Gln Ser Pro Asp Val 
            180                 185                 190         


Leu Val Tyr Gly Leu Lys Asn Lys Lys Ala His Ile 
        195                 200                 


<210> 7563
<211> 102
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<400> 7563
Met Ser Ser Pro Pro Glu Gly Lys Leu Glu Xaa Lys Ala Gly His Pro 
1               5                   10                  15      


Pro Ala Val Lys Ala Gly Gly Met Arg Ile Val Gln Lys His Pro His 
            20                  25                  30          


Xaa Gly Asp Xaa Lys Glu Glu Lys Asp Lys Asp Asp Gln Glu Trp Glu 
        35                  40                  45              


Ser Pro Ser Pro Pro Lys Pro Xaa Val Phe Ile Ser Gly Val Ile Ala 
    50                  55                  60                  


Arg Gly Asp Lys Asp Phe Pro Pro Ala Ala Ala Gln Val Ala His Gln 
65                  70                  75                  80  


Lys Pro His Ala Ser Met Asp Lys His Pro Ser Pro Arg Xaa Gln His 
                85                  90                  95      


Ile Gln Gln Pro Arg Lys 
            100         


<210> 7564
<211> 45
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<400> 7564
Glu Ser Cys Ile Gln Tyr Tyr Leu Glu Asn Asn Trp Leu Gln His Glu 
1               5                   10                  15      


Lys Ala Pro Xaa Glu Glu Gly Lys Lys Glu Leu Leu Phe Leu Ser Asn 
            20                  25                  30          


Ala Asn Pro Ser Leu Leu Glu Arg His Cys Ala Tyr Leu 
        35                  40                  45  


<210> 7565
<211> 140
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<400> 7565
Gly Ile Xaa Arg Val Arg Asn Ala Xaa Asp Ala Val Gly Ile Val Leu 
1               5                   10                  15      


Lys Glu Leu Lys Arg Gln Ser Ser Leu Gly Met Phe His Leu Leu Val 
            20                  25                  30          


Ala Val Asp Gly Ile Asn Ala Leu Trp Gly Arg Xaa Xaa Leu Lys Arg 
        35                  40                  45              


Glu Asp Lys Ser Pro Ile Ala Pro Glu Glu Leu Ala Leu Val His Asn 
    50                  55                  60                  


Leu Arg Lys Met Met Lys Asn Asp Trp Glu Gly Phe Asp Ala Leu Asp 
65                  70                  75                  80  


Pro Phe Ile Pro Ile Leu Val Ser Asn Tyr Asn Pro Lys Glu Phe Glu 
                85                  90                  95      


Ser Cys Ile Gln Tyr Tyr Leu Glu Asn Asn Trp Leu Gln His Glu Lys 
            100                 105                 110         


Ala Pro Xaa Glu Glu Gly Lys Lys Glu Leu Leu Phe Leu Ser Asn Ala 
        115                 120                 125             


Asn Pro Ser Leu Leu Glu Arg His Cys Ala Tyr Leu 
    130                 135                 140 


<210> 7566
<211> 115
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (44)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<400> 7566
Gly Ile Xaa Arg Val Arg Asn Ala Xaa Asp Ala Val Gly Ile Val Leu 
1               5                   10                  15      


Lys Glu Leu Lys Arg Gln Ser Ser Leu Gly Met Phe His Leu Leu Val 
            20                  25                  30          


Ala Val Asp Gly Ile Asn Ala Leu Trp Gly Arg Xaa Xaa Leu Lys Arg 
        35                  40                  45              


Glu Asp Lys Ser Pro Ile Ala Pro Glu Glu Leu Ala Leu Val His Asn 
    50                  55                  60                  


Leu Arg Lys Met Met Lys Asn Asp Trp His Gly Gly Ala Ile Val Ser 
65                  70                  75                  80  


Ala Leu Ser Gln Xaa Gly Ser Leu Phe Lys Pro Arg Lys Ala Tyr Leu 
                85                  90                  95      


Pro Gln Glu Leu Leu Gly Lys Leu Leu Gln Lys Lys Gly Lys Lys Ser 
            100                 105                 110         


Cys Cys Ser 
        115 


<210> 7567
<211> 120
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (104)..(105)
<223> Selenocysteine

<400> 7567
Met Met Leu Lys Gly Ile Xaa Arg Leu Ile Ser Arg Ile His Lys Ala 
1               5                   10                  15      


Lys His Gly Asp Gln His Glu Gly Gln His Tyr Asn Ile Ser Pro Gln 
            20                  25                  30          


Asp Leu Glu Xaa Val Phe Pro His Gly Leu Pro Pro Arg Phe Val Met 
        35                  40                  45              


Gln Val Lys Xaa Phe Ser Glu Ala Cys Leu Met Asp Trp Leu Ile Leu 
    50                  55                  60                  


His Ile Pro Asp Ala His Leu Trp Val Lys Asn Cys Arg Asp Leu Leu 
65                  70                  75                  80  


Gln Ser Ser Tyr Asn Lys Gln Arg Phe Asp Gln Pro Leu Glu Ala Ser 
                85                  90                  95      


Xaa Trp Leu Lys Asn Phe Lys Xaa Xaa Asn Glu Arg Phe Leu Asn Gln 
            100                 105                 110         


Ile Lys Val Gln Glu Lys Tyr Val 
        115                 120 


<210> 7568
<211> 357
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (74)..(74)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (196)..(196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Selenocysteine

<400> 7568
Met Met Leu Lys Gly Ile Xaa Arg Leu Ile Ser Arg Ile His Lys Ala 
1               5                   10                  15      


Lys His Gly Asp Gln His Glu Gly Gln His Tyr Asn Ile Ser Pro Gln 
            20                  25                  30          


Asp Leu Glu Xaa Val Phe Pro His Gly Leu Pro Pro Arg Phe Val Met 
        35                  40                  45              


Gln Val Lys Xaa Phe Ser Glu Ala Cys Leu Met Val Arg Lys Pro Ala 
    50                  55                  60                  


Leu Glu Leu Leu His Tyr Leu Lys Asn Xaa Ser Phe Ala Tyr Pro Ala 
65                  70                  75                  80  


Ile Arg Tyr Leu Leu Tyr Gly Glu Lys Gly Xaa Gly Lys Xaa Leu Ser 
                85                  90                  95      


Leu Cys His Val Ile His Phe Cys Ala Lys Gln Asp Trp Leu Ile Leu 
            100                 105                 110         


His Ile Pro Asp Ala His Leu Trp Val Lys Asn Cys Arg Asp Leu Leu 
        115                 120                 125             


Gln Ser Ser Tyr Asn Lys Gln Arg Phe Asp Gln Pro Leu Glu Ala Ser 
    130                 135                 140                 


Xaa Trp Leu Lys Asn Phe Lys Xaa Xaa Asn Glu Arg Phe Leu Asn Gln 
145                 150                 155                 160 


Ile Lys Val Gln Glu Lys Tyr Val Trp Asn Lys Arg Glu Ser Xaa Glu 
                165                 170                 175     


Lys Gly Ser Pro Leu Gly Glu Val Val Glu Gln Gly Ile Xaa Arg Val 
            180                 185                 190         


Arg Asn Ala Xaa Asp Ala Val Gly Ile Val Leu Lys Glu Leu Lys Arg 
        195                 200                 205             


Gln Ser Ser Leu Gly Met Phe His Leu Leu Val Ala Val Asp Gly Ile 
    210                 215                 220                 


Asn Ala Leu Trp Gly Arg Xaa Xaa Leu Lys Arg Glu Asp Lys Ser Pro 
225                 230                 235                 240 


Ile Ala Pro Glu Glu Leu Ala Leu Val His Asn Leu Arg Lys Met Met 
                245                 250                 255     


Lys Asn Asp Trp His Gly Gly Ala Ile Val Ser Ala Leu Ser Gln Xaa 
            260                 265                 270         


Gly Ser Leu Phe Lys Pro Arg Lys Ala Tyr Leu Pro Gln Glu Leu Leu 
        275                 280                 285             


Gly Lys Glu Gly Phe Asp Ala Leu Asp Pro Phe Ile Pro Ile Leu Val 
    290                 295                 300                 


Ser Asn Tyr Asn Pro Lys Glu Phe Glu Ser Cys Ile Gln Tyr Tyr Leu 
305                 310                 315                 320 


Glu Asn Asn Trp Leu Gln His Glu Lys Ala Pro Xaa Glu Glu Gly Lys 
                325                 330                 335     


Lys Glu Leu Leu Phe Leu Ser Asn Ala Asn Pro Ser Leu Leu Glu Arg 
            340                 345                 350         


His Cys Ala Tyr Leu 
        355         


<210> 7569
<211> 267
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (158)..(158)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (179)..(179)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(215)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<400> 7569
Met Met Leu Lys Gly Ile Xaa Arg Leu Ile Ser Arg Ile His Lys Leu 
1               5                   10                  15      


Asp Pro Gly Arg Phe Leu His Met Gly Xaa Gln Ala Arg Gln Ser Ile 
            20                  25                  30          


Ala Ala His Leu Asp Asn Gln Val Pro Val Glu Ser Pro Arg Ala Ile 
        35                  40                  45              


Ser Arg Xaa Asn Glu Asn Asp Pro Ala Lys His Gly Asp Gln His Glu 
    50                  55                  60                  


Gly Gln His Tyr Asn Ile Ser Pro Gln Asp Leu Glu Xaa Val Phe Pro 
65                  70                  75                  80  


His Gly Leu Pro Pro Arg Phe Val Met Gln Asp Trp Leu Ile Leu His 
                85                  90                  95      


Ile Pro Asp Ala His Leu Trp Val Lys Asn Cys Arg Asp Leu Leu Gln 
            100                 105                 110         


Ser Ser Tyr Asn Lys Gln Arg Phe Asp Gln Pro Leu Glu Ala Ser Xaa 
        115                 120                 125             


Trp Leu Lys Asn Phe Lys Xaa Xaa Asn Glu Arg Phe Leu Asn Gln Ile 
    130                 135                 140                 


Lys Val Gln Glu Lys Tyr Val Trp Asn Lys Arg Glu Ser Xaa Glu Lys 
145                 150                 155                 160 


Gly Ser Pro Leu Gly Glu Val Val Glu Gln Gly Ile Xaa Arg Val Arg 
                165                 170                 175     


Asn Ala Xaa Asp Ala Val Gly Ile Val Leu Lys Glu Leu Lys Arg Gln 
            180                 185                 190         


Ser Ser Leu Gly Met Phe His Leu Leu Val Ala Val Asp Gly Ile Asn 
        195                 200                 205             


Ala Leu Trp Gly Arg Xaa Xaa Leu Lys Arg Glu Asp Lys Ser Pro Ile 
    210                 215                 220                 


Ala Pro Glu Glu Leu Ala Leu Val His Asn Leu Arg Lys Met Met Lys 
225                 230                 235                 240 


Asn Asp Trp His Gly Gly Ala Ile Val Ser Ala Leu Ser Gln Xaa Gly 
                245                 250                 255     


Ser Leu Phe Lys Pro Arg Lys Ala Tyr Leu Pro 
            260                 265         


<210> 7570
<211> 181
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<400> 7570
Met Met Leu Lys Gly Ile Xaa Arg Leu Ile Ser Arg Ile His Lys Leu 
1               5                   10                  15      


Asp Pro Gly Arg Phe Leu His Met Gly Xaa Gln Ala Arg Gln Ser Ile 
            20                  25                  30          


Ala Ala His Leu Asp Asn Gln Val Pro Val Glu Ser Pro Arg Ala Ile 
        35                  40                  45              


Ser Arg Xaa Asn Glu Asn Asp Pro Ala Lys His Gly Asp Gln His Glu 
    50                  55                  60                  


Gly Gln His Tyr Asn Ile Ser Pro Gln Asp Leu Glu Xaa Val Phe Pro 
65                  70                  75                  80  


His Gly Leu Pro Pro Arg Phe Val Met Gln Val Lys Xaa Phe Ser Glu 
                85                  90                  95      


Ala Cys Leu Met Asp Trp Leu Ile Leu His Ile Pro Asp Ala His Leu 
            100                 105                 110         


Trp Val Lys Asn Cys Arg Asp Leu Leu Gln Ser Ser Tyr Asn Lys Gln 
        115                 120                 125             


Arg Phe Asp Gln Pro Leu Glu Ala Ser Xaa Trp Leu Lys Asn Phe Lys 
    130                 135                 140                 


Xaa Xaa Asn Glu Arg Phe Leu Asn Gln Gly Ile Xaa Arg Val Arg Asn 
145                 150                 155                 160 


Ala Xaa Asp Ala Val Gly Ile Val Leu Lys Glu Leu Lys Arg Gln Ser 
                165                 170                 175     


Ser Leu Gly Met Phe 
            180     


<210> 7571
<211> 299
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(273)
<223> Selenocysteine

<400> 7571
Met Met Leu Lys Gly Ile Xaa Arg Leu Ile Ser Arg Ile His Lys Leu 
1               5                   10                  15      


Asp Pro Gly Arg Phe Leu His Met Gly Xaa Gln Ala Arg Gln Ser Ile 
            20                  25                  30          


Ala Ala His Leu Asp Asn Gln Val Pro Val Glu Ser Pro Arg Ala Ile 
        35                  40                  45              


Ser Arg Xaa Asn Glu Asn Asp Pro Ala Lys His Gly Asp Gln His Glu 
    50                  55                  60                  


Gly Gln His Tyr Asn Ile Ser Pro Gln Asp Leu Glu Xaa Val Phe Pro 
65                  70                  75                  80  


His Gly Leu Pro Pro Arg Phe Val Met Gln Val Lys Xaa Phe Ser Glu 
                85                  90                  95      


Ala Cys Leu Met Val Arg Lys Pro Ala Leu Glu Leu Leu His Tyr Leu 
            100                 105                 110         


Lys Asn Xaa Ser Phe Ala Tyr Pro Ala Ile Arg Tyr Leu Leu Tyr Gly 
        115                 120                 125             


Glu Lys Gly Xaa Gly Lys Xaa Leu Ser Leu Cys His Val Ile His Phe 
    130                 135                 140                 


Cys Ala Lys Gln Asp Trp Leu Ile Leu His Ile Pro Asp Ala His Leu 
145                 150                 155                 160 


Trp Val Lys Asn Cys Arg Asp Leu Leu Gln Ser Ser Tyr Asn Lys Gln 
                165                 170                 175     


Arg Phe Asp Gln Pro Leu Glu Ala Ser Xaa Trp Leu Lys Asn Phe Lys 
            180                 185                 190         


Xaa Xaa Asn Glu Arg Phe Leu Asn Gln Ile Lys Val Gln Glu Lys Tyr 
        195                 200                 205             


Val Trp Asn Lys Arg Glu Ser Xaa Glu Lys Gly Ser Pro Leu Gly Glu 
    210                 215                 220                 


Val Val Glu Gln Gly Ile Xaa Arg Val Arg Asn Ala Xaa Asp Ala Val 
225                 230                 235                 240 


Gly Ile Val Leu Lys Glu Leu Lys Arg Gln Ser Ser Leu Gly Met Phe 
                245                 250                 255     


His Leu Leu Val Ala Val Asp Gly Ile Asn Ala Leu Trp Gly Arg Xaa 
            260                 265                 270         


Xaa Leu Lys Arg Glu Asp Lys Ser Pro Ile Ala Pro Glu Glu Leu Ala 
        275                 280                 285             


Leu Val His Asn Leu Arg Lys Met Met Lys Asn 
    290                 295                 


<210> 7572
<211> 398
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (115)..(115)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (135)..(135)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (193)..(194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Selenocysteine

<400> 7572
Met Met Leu Lys Gly Ile Xaa Arg Leu Ile Ser Arg Ile His Lys Leu 
1               5                   10                  15      


Asp Pro Gly Arg Phe Leu His Met Gly Xaa Gln Ala Arg Gln Ser Ile 
            20                  25                  30          


Ala Ala His Leu Asp Asn Gln Val Pro Val Glu Ser Pro Arg Ala Ile 
        35                  40                  45              


Ser Arg Xaa Asn Glu Asn Asp Pro Ala Lys His Gly Asp Gln His Glu 
    50                  55                  60                  


Gly Gln His Tyr Asn Ile Ser Pro Gln Asp Leu Glu Xaa Val Phe Pro 
65                  70                  75                  80  


His Gly Leu Pro Pro Arg Phe Val Met Gln Val Lys Xaa Phe Ser Glu 
                85                  90                  95      


Ala Cys Leu Met Val Arg Lys Pro Ala Leu Glu Leu Leu His Tyr Leu 
            100                 105                 110         


Lys Asn Xaa Ser Phe Ala Tyr Pro Ala Ile Arg Tyr Leu Leu Tyr Gly 
        115                 120                 125             


Glu Lys Gly Xaa Gly Lys Xaa Leu Ser Leu Cys His Val Ile His Phe 
    130                 135                 140                 


Cys Ala Lys Gln Asp Trp Leu Ile Leu His Ile Pro Asp Ala His Leu 
145                 150                 155                 160 


Trp Val Lys Asn Cys Arg Asp Leu Leu Gln Ser Ser Tyr Asn Lys Gln 
                165                 170                 175     


Arg Phe Asp Gln Pro Leu Glu Ala Ser Xaa Trp Leu Lys Asn Phe Lys 
            180                 185                 190         


Xaa Xaa Asn Glu Arg Phe Leu Asn Gln Ile Lys Val Gln Glu Lys Tyr 
        195                 200                 205             


Val Trp Asn Lys Arg Glu Ser Xaa Glu Lys Gly Ser Pro Leu Gly Glu 
    210                 215                 220                 


Val Val Glu Gln Gly Ile Xaa Arg Val Arg Asn Ala Xaa Asp Ala Val 
225                 230                 235                 240 


Gly Ile Val Leu Lys Glu Leu Lys Arg Gln Ser Ser Leu Gly Met Phe 
                245                 250                 255     


His Leu Leu Val Ala Val Asp Gly Ile Asn Ala Leu Trp Gly Arg Xaa 
            260                 265                 270         


Xaa Leu Lys Arg Glu Asp Lys Ser Pro Ile Ala Pro Glu Glu Leu Ala 
        275                 280                 285             


Leu Val His Asn Leu Arg Lys Met Met Lys Asn Asp Trp His Gly Gly 
    290                 295                 300                 


Ala Ile Val Ser Ala Leu Ser Gln Xaa Gly Ser Leu Phe Lys Pro Arg 
305                 310                 315                 320 


Lys Ala Tyr Leu Pro Gln Glu Leu Leu Gly Lys Glu Gly Phe Asp Ala 
                325                 330                 335     


Leu Asp Pro Phe Ile Pro Ile Leu Val Ser Asn Tyr Asn Pro Lys Glu 
            340                 345                 350         


Phe Glu Ser Cys Ile Gln Tyr Tyr Leu Glu Asn Asn Trp Leu Gln His 
        355                 360                 365             


Glu Lys Ala Pro Xaa Glu Glu Gly Lys Lys Glu Leu Leu Phe Leu Ser 
    370                 375                 380                 


Asn Ala Asn Pro Ser Leu Leu Glu Arg His Cys Ala Tyr Leu 
385                 390                 395             


<210> 7573
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<400> 7573
Met Met Leu Lys Gly Ile Xaa Arg Leu Ile Ser Arg Ile His Lys Leu 
1               5                   10                  15      


Asp Pro Gly Arg Phe Leu His Met Gly Xaa Gln Ala Arg Gln Ser Ile 
            20                  25                  30          


Ala Ala His Leu Asp Asn Gln Val Pro Val Glu Ser Pro Arg Ala Ile 
        35                  40                  45              


Ser Arg Xaa Asn Glu Asn Asp Pro Ala Lys His Gly Asp Gln His Glu 
    50                  55                  60                  


Gly Gln His Tyr Asn Ile Ser Pro Gln Asp Leu Glu Xaa Val Phe Pro 
65                  70                  75                  80  


His Gly Leu Pro Pro Arg Phe Val Met Gln Val Leu Lys Xaa Gly Asn 
                85                  90                  95      


Gly Ile Gly Gly Ser Pro Glu Tyr Lys Leu Leu Leu Ala Lys Gly Trp 
            100                 105                 110         


Gly 
    


<210> 7574
<211> 364
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (159)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (203)..(203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (238)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (339)..(339)
<223> Selenocysteine

<400> 7574
Met Met Leu Lys Gly Ile Xaa Arg Leu Ile Ser Arg Ile His Lys Leu 
1               5                   10                  15      


Asp Pro Gly Arg Phe Leu His Met Gly Xaa Gln Ala Arg Gln Ser Ile 
            20                  25                  30          


Ala Ala His Leu Asp Asn Gln Val Pro Val Glu Ser Pro Arg Ala Ile 
        35                  40                  45              


Ser Arg Xaa Asn Glu Asn Asp Pro Val Lys Xaa Phe Ser Glu Ala Cys 
    50                  55                  60                  


Leu Met Val Arg Lys Pro Ala Leu Glu Leu Leu His Tyr Leu Lys Asn 
65                  70                  75                  80  


Xaa Ser Phe Ala Tyr Pro Ala Ile Arg Tyr Leu Leu Tyr Gly Glu Lys 
                85                  90                  95      


Gly Xaa Gly Lys Xaa Leu Ser Leu Cys His Val Ile His Phe Cys Ala 
            100                 105                 110         


Lys Gln Asp Trp Leu Ile Leu His Ile Pro Asp Ala His Leu Trp Val 
        115                 120                 125             


Lys Asn Cys Arg Asp Leu Leu Gln Ser Ser Tyr Asn Lys Gln Arg Phe 
    130                 135                 140                 


Asp Gln Pro Leu Glu Ala Ser Xaa Trp Leu Lys Asn Phe Lys Xaa Xaa 
145                 150                 155                 160 


Asn Glu Arg Phe Leu Asn Gln Ile Lys Val Gln Glu Lys Tyr Val Trp 
                165                 170                 175     


Asn Lys Arg Glu Ser Xaa Glu Lys Gly Ser Pro Leu Gly Glu Val Val 
            180                 185                 190         


Glu Gln Gly Ile Xaa Arg Val Arg Asn Ala Xaa Asp Ala Val Gly Ile 
        195                 200                 205             


Val Leu Lys Glu Leu Lys Arg Gln Ser Ser Leu Gly Met Phe His Leu 
    210                 215                 220                 


Leu Val Ala Val Asp Gly Ile Asn Ala Leu Trp Gly Arg Xaa Xaa Leu 
225                 230                 235                 240 


Lys Arg Glu Asp Lys Ser Pro Ile Ala Pro Glu Glu Leu Ala Leu Val 
                245                 250                 255     


His Asn Leu Arg Lys Met Met Lys Asn Asp Trp His Gly Gly Ala Ile 
            260                 265                 270         


Val Ser Ala Leu Ser Gln Xaa Gly Ser Leu Phe Lys Pro Arg Lys Ala 
        275                 280                 285             


Tyr Leu Pro Gln Glu Leu Leu Gly Lys Glu Gly Phe Asp Ala Leu Asp 
    290                 295                 300                 


Pro Phe Ile Pro Ile Leu Val Ser Asn Tyr Asn Pro Lys Glu Phe Glu 
305                 310                 315                 320 


Ser Cys Ile Gln Tyr Tyr Leu Glu Asn Asn Trp Leu Gln His Glu Lys 
                325                 330                 335     


Ala Pro Xaa Glu Glu Gly Lys Lys Glu Leu Leu Phe Leu Ser Asn Ala 
            340                 345                 350         


Asn Pro Ser Leu Leu Glu Arg His Cys Ala Tyr Leu 
        355                 360                 


<210> 7575
<211> 65
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<400> 7575
Arg Leu Ile Ser Arg Ile His Lys Ala Lys His Gly Asp Gln His Glu 
1               5                   10                  15      


Gly Gln His Tyr Asn Ile Ser Pro Gln Asp Leu Glu Xaa Val Phe Pro 
            20                  25                  30          


His Gly Leu Pro Pro Arg Phe Val Met Gln Val Leu Lys Xaa Gly Asn 
        35                  40                  45              


Gly Ile Gly Gly Ser Pro Glu Tyr Lys Leu Leu Leu Ala Lys Gly Trp 
    50                  55                  60                  


Gly 
65  


<210> 7576
<211> 242
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (131)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(184)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<400> 7576
Xaa Glu Gly Gln His Tyr Asn Ile Ser Pro Gln Asp Leu Glu Xaa Val 
1               5                   10                  15      


Phe Pro His Gly Leu Pro Pro Arg Phe Val Met Gln Val Lys Xaa Phe 
            20                  25                  30          


Ser Glu Ala Cys Leu Met Val Arg Lys Pro Ala Leu Glu Leu Leu His 
        35                  40                  45              


Tyr Leu Lys Asn Xaa Ser Phe Ala Tyr Pro Ala Ile Arg Tyr Leu Leu 
    50                  55                  60                  


Tyr Gly Glu Lys Gly Xaa Gly Lys Xaa Leu Ser Leu Cys His Val Ile 
65                  70                  75                  80  


His Phe Cys Ala Lys Gln Asp Trp Leu Ile Leu His Ile Pro Asp Ala 
                85                  90                  95      


His Leu Trp Val Lys Asn Cys Arg Asp Leu Leu Gln Ser Ser Tyr Asn 
            100                 105                 110         


Lys Gln Arg Phe Asp Gln Pro Leu Glu Ala Ser Xaa Trp Leu Lys Asn 
        115                 120                 125             


Phe Lys Xaa Xaa Asn Glu Arg Phe Leu Asn Gln Gly Ile Xaa Arg Val 
    130                 135                 140                 


Arg Asn Ala Xaa Asp Ala Val Gly Ile Val Leu Lys Glu Leu Lys Arg 
145                 150                 155                 160 


Gln Ser Ser Leu Gly Met Phe His Leu Leu Val Ala Val Asp Gly Ile 
                165                 170                 175     


Asn Ala Leu Trp Gly Arg Xaa Xaa Leu Lys Arg Glu Asp Lys Ser Pro 
            180                 185                 190         


Ile Ala Pro Glu Glu Leu Ala Leu Val His Asn Leu Arg Lys Met Met 
        195                 200                 205             


Lys Asn Asp Trp His Gly Gly Ala Ile Val Ser Ala Leu Ser Gln Xaa 
    210                 215                 220                 


Gly Ser Leu Phe Lys Pro Arg Lys Ala Tyr Leu Pro Gln Glu Leu Leu 
225                 230                 235                 240 


Gly Lys 
        


<210> 7577
<211> 210
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(56)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (185)..(185)
<223> Selenocysteine

<400> 7577
Xaa Gly Ser Pro Leu Gly Glu Val Val Glu Gln Gly Ile Xaa Arg Val 
1               5                   10                  15      


Arg Asn Ala Xaa Asp Ala Val Gly Ile Val Leu Lys Glu Leu Lys Arg 
            20                  25                  30          


Gln Ser Ser Leu Gly Met Phe His Leu Leu Val Ala Val Asp Gly Ile 
        35                  40                  45              


Asn Ala Leu Trp Gly Arg Xaa Xaa Leu Lys Arg Glu Asp Lys Ser Pro 
    50                  55                  60                  


Ile Ala Pro Glu Glu Leu Ala Leu Val His Asn Leu Arg Lys Met Met 
65                  70                  75                  80  


Lys Asn Asp Trp His Gly Gly Ala Ile Val Ser Ala Leu Ser Gln Xaa 
                85                  90                  95      


Gly Ser Leu Phe Lys Pro Arg Lys Ala Tyr Leu Pro Gln Glu Leu Leu 
            100                 105                 110         


Gly Lys Gly Phe Xaa Xaa Trp Pro Arg Leu Val Trp Asn Ser Trp Ala 
        115                 120                 125             


Gln Ala Ile Cys Pro Ser Gln Pro Pro Lys Val Leu Gly Leu Gln Glu 
    130                 135                 140                 


Gly Phe Asp Ala Leu Asp Pro Phe Ile Pro Ile Leu Val Ser Asn Tyr 
145                 150                 155                 160 


Asn Pro Lys Glu Phe Glu Ser Cys Ile Gln Tyr Tyr Leu Glu Asn Asn 
                165                 170                 175     


Trp Leu Gln His Glu Lys Ala Pro Xaa Glu Glu Gly Lys Lys Glu Leu 
            180                 185                 190         


Leu Phe Leu Ser Asn Ala Asn Pro Ser Leu Leu Glu Arg His Cys Ala 
        195                 200                 205             


Tyr Leu 
    210 


<210> 7578
<211> 106
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Selenocysteine

<400> 7578
Xaa Leu Lys Arg Glu Asp Lys Ser Pro Ile Ala Pro Glu Glu Leu Ala 
1               5                   10                  15      


Leu Val His Asn Leu Arg Lys Met Met Lys Asn Asp Trp His Gly Gly 
            20                  25                  30          


Ala Ile Val Ser Ala Leu Ser Gln Xaa Gly Ser Leu Phe Lys Pro Arg 
        35                  40                  45              


Lys Ala Tyr Leu Pro Gln Glu Leu Leu Gly Lys Glu Phe Glu Ser Cys 
    50                  55                  60                  


Ile Gln Tyr Tyr Leu Glu Asn Asn Trp Leu Gln His Glu Lys Ala Pro 
65                  70                  75                  80  


Xaa Glu Glu Gly Lys Lys Glu Leu Leu Phe Leu Ser Asn Ala Asn Pro 
                85                  90                  95      


Ser Leu Leu Glu Arg His Cys Ala Tyr Leu 
            100                 105     


<210> 7579
<211> 1364
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (821)..(821)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (842)..(842)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (897)..(897)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (906)..(906)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (952)..(952)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (962)..(962)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (976)..(976)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (987)..(987)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (999)..(999)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1043)..(1043)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1072)..(1072)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1095)..(1095)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1137)..(1137)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1152)..(1152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1159)..(1160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1166)..(1166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1196)..(1196)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1200)..(1200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1205)..(1205)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1243)..(1243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1279)..(1279)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1300)..(1301)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1306)..(1306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1353)..(1353)
<223> Selenocysteine

<400> 7579
Met Xaa Val Phe Arg Gln Glu Asn Val Asp Asp Tyr Tyr Asp Xaa Gly 
1               5                   10                  15      


Glu Glu Leu Gly Ser Gly Gln Phe Ala Val Val Lys Lys Cys Arg Glu 
            20                  25                  30          


Lys Ser Xaa Gly Leu Gln Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 
        35                  40                  45              


Xaa Lys Ser Ser Arg Arg Gly Val Ser Arg Glu Asp Ile Glu Arg Glu 
    50                  55                  60                  


Val Ser Ile Leu Lys Glu Ile Gln His Pro Asn Val Ile Xaa Leu His 
65                  70                  75                  80  


Glu Val Tyr Glu Asn Lys Xaa Asp Val Ile Leu Ile Leu Glu Leu Val 
                85                  90                  95      


Ala Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Xaa 
            100                 105                 110         


Glu Glu Glu Ala Xaa Glu Phe Leu Lys Gln Ile Leu Asn Gly Val Tyr 
        115                 120                 125             


Tyr Leu His Ser Leu Gln Ile Ala His Phe Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 


Ile Met Leu Leu Asp Arg Asn Val Pro Lys Pro Arg Ile Lys Ile Ile 
145                 150                 155                 160 


Asp Phe Gly Leu Ala His Lys Ile Asp Phe Gly Asn Glu Phe Lys Asn 
                165                 170                 175     


Ile Phe Gly Xaa Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu 
            180                 185                 190         


Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Xaa Tyr 
        195                 200                 205             


Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Asp Xaa Lys Gln Glu 
    210                 215                 220                 


Xaa Leu Ala Asn Val Ser Ala Val Asn Tyr Glu Phe Glu Asp Glu Tyr 
225                 230                 235                 240 


Phe Ser Asn Xaa Ser Ala Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu 
                245                 250                 255     


Val Lys Asp Pro Lys Lys Arg Met Xaa Ile Gln Asp Ser Leu Gln His 
            260                 265                 270         


Pro Trp Ile Lys Pro Lys Asp Xaa Gln Gln Ala Leu Ser Arg Lys Ala 
        275                 280                 285             


Ser Ala Val Asn Met Glu Lys Phe Lys Lys Phe Ala Ala Arg Lys Lys 
    290                 295                 300                 


Trp Lys Gln Ser Val Arg Leu Ile Ser Leu Cys Gln Arg Leu Ser Arg 
305                 310                 315                 320 


Ser Phe Leu Ser Arg Ser Asn Met Ser Val Ala Arg Ser Asp Asp Xaa 
                325                 330                 335     


Leu Asp Glu Glu Asp Ser Phe Val Met Lys Ala Ile Ile His Ala Ile 
            340                 345                 350         


Asn Asp Asp Asn Val Pro Gly Leu Gln His Leu Leu Gly Ser Leu Ser 
        355                 360                 365             


Asn Tyr Asp Val Asn Gln Pro Asn Lys His Gly Xaa Pro Pro Leu Leu 
    370                 375                 380                 


Ile Ala Ala Gly Cys Gly Asn Ile Gln Ile Leu Gln Leu Leu Ile Lys 
385                 390                 395                 400 


Arg Gly Ser Arg Ile Asp Val Gln Asp Lys Gly Gly Ser Asn Ala Val 
                405                 410                 415     


Tyr Trp Ala Ala Arg His Gly His Val Asp Xaa Leu Lys Phe Leu Ser 
            420                 425                 430         


Glu Asn Lys Cys Pro Leu Asp Val Lys Asp Lys Ser Gly Glu Met Ala 
        435                 440                 445             


Leu His Val Ala Ala Arg Tyr Gly His Ala Asp Val Ala Gln Leu Leu 
    450                 455                 460                 


Cys Ser Phe Gly Ser Asn Pro Asn Ile Gln Asp Lys Glu Glu Glu Xaa 
465                 470                 475                 480 


Pro Leu His Cys Ala Ala Trp His Gly Tyr Tyr Ser Val Ala Lys Ala 
                485                 490                 495     


Leu Cys Glu Ala Gly Cys Asn Val Asn Ile Lys Asn Arg Glu Gly Glu 
            500                 505                 510         


Xaa Pro Leu Leu Xaa Ala Ser Ala Arg Gly Tyr His Asp Ile Val Glu 
        515                 520                 525             


Cys Leu Ala Glu His Gly Ala Asp Leu Asn Ala Cys Asp Lys Asp Gly 
    530                 535                 540                 


His Ile Ala Leu His Leu Ala Val Arg Arg Cys Gln Met Glu Val Ile 
545                 550                 555                 560 


Lys Xaa Leu Leu Ser Gln Gly Cys Phe Val Asp Tyr Gln Asp Arg His 
                565                 570                 575     


Gly Asn Xaa Pro Leu His Val Ala Cys Lys Asp Gly Asn Met Pro Ile 
            580                 585                 590         


Val Val Ala Leu Cys Glu Ala Asn Cys Asn Leu Asp Ile Ser Asn Lys 
        595                 600                 605             


Tyr Gly Arg Xaa Pro Leu His Leu Ala Ala Asn Asn Gly Ile Leu Asp 
    610                 615                 620                 


Val Val Arg Tyr Leu Cys Leu Met Gly Ala Ser Val Glu Ala Leu Xaa 
625                 630                 635                 640 


Xaa Asp Gly Lys Xaa Ala Glu Asp Leu Ala Arg Ser Glu Gln His Glu 
                645                 650                 655     


His Val Ala Gly Leu Leu Ala Arg Leu Arg Lys Asp Xaa His Arg Gly 
            660                 665                 670         


Leu Phe Ile Gln Gln Leu Arg Pro Xaa Gln Asn Leu Gln Pro Arg Ile 
        675                 680                 685             


Lys Leu Lys Leu Phe Gly His Ser Gly Ser Gly Lys Xaa Xaa Leu Val 
    690                 695                 700                 


Glu Ser Leu Lys Cys Gly Leu Leu Arg Ser Phe Phe Arg Arg Arg Arg 
705                 710                 715                 720 


Pro Arg Leu Ser Ser Xaa Asn Ser Ser Arg Phe Pro Pro Ser Pro Leu 
                725                 730                 735     


Ala Ser Lys Pro Xaa Val Ser Val Ser Ile Asn Asn Leu Tyr Pro Gly 
            740                 745                 750         


Cys Glu Asn Val Ser Val Arg Ser Arg Ser Met Met Phe Glu Pro Gly 
        755                 760                 765             


Leu Xaa Lys Gly Met Leu Glu Val Phe Val Ala Pro Xaa His His Pro 
    770                 775                 780                 


His Cys Ser Ala Asp Asp Gln Ser Xaa Lys Ala Ile Asp Ile Gln Asn 
785                 790                 795                 800 


Ala Tyr Leu Asn Ala Phe Gly Gly Lys Leu Lys Asn Pro Leu Gln Val 
                805                 810                 815     


Val Leu Val Ala Xaa His Ala Asp Ile Met Asn Val Pro Arg Pro Ala 
            820                 825                 830         


Gly Gly Glu Phe Gly Tyr Asp Lys Asp Xaa Ser Leu Leu Lys Glu Ile 
        835                 840                 845             


Arg Asn Arg Phe Gly Asn Asp Leu His Ile Ser Asn Lys Leu Phe Val 
    850                 855                 860                 


Leu Asp Ala Gly Ala Ser Gly Ser Lys Asp Met Lys Val Leu Arg Asn 
865                 870                 875                 880 


His Leu Gln Glu Ile Arg Ser Gln Ile Val Ser Val Cys Pro Pro Met 
                885                 890                 895     


Xaa His Leu Cys Glu Lys Ile Ile Ser Xaa Leu Pro Ser Trp Arg Lys 
            900                 905                 910         


Leu Asn Gly Pro Asn Gln Leu Met Ser Leu Gln Gln Phe Val Tyr Asp 
        915                 920                 925             


Val Gln Asp Gln Leu Asn Pro Leu Ala Ser Glu Glu Asp Leu Arg Arg 
    930                 935                 940                 


Ile Ala Gln Gln Leu His Ser Xaa Gly Glu Ile Asn Ile Met Gln Ser 
945                 950                 955                 960 


Glu Xaa Val Gln Asp Val Leu Leu Leu Asp Pro Arg Trp Leu Cys Xaa 
                965                 970                 975     


Asn Val Leu Gly Lys Leu Leu Ser Val Glu Xaa Pro Arg Ala Leu His 
            980                 985                 990         


His Tyr Arg Gly Arg Tyr Xaa Val  Glu Asp Ile Gln Arg  Leu Val Pro 
        995                 1000                 1005             


Asp Ser  Asp Val Glu Glu Leu  Leu Gln Ile Leu Asp  Ala Met Asp 
    1010                 1015                 1020             


Ile Cys  Ala Arg Asp Leu Ser  Ser Gly Xaa Met Val  Asp Val Pro 
    1025                 1030                 1035             


Ala Leu  Ile Lys Xaa Asp Asn  Leu His Arg Ser Trp  Ala Asp Glu 
    1040                 1045                 1050             


Glu Asp  Glu Val Met Val Tyr  Gly Gly Val Arg Ile  Val Pro Val 
    1055                 1060                 1065             


Glu His  Leu Xaa Pro Phe Pro  Cys Gly Ile Phe His  Lys Val Gln 
    1070                 1075                 1080             


Val Asn  Leu Cys Arg Trp Ile  His Gln Gln Ser Xaa  Glu Gly Asp 
    1085                 1090                 1095             


Ala Asp  Ile Arg Leu Trp Val  Asn Gly Cys Lys Leu  Ala Asn Arg 
    1100                 1105                 1110             


Gly Ala  Glu Leu Leu Val Leu  Leu Val Asn His Gly  Gln Gly Ile 
    1115                 1120                 1125             


Glu Val  Gln Val Arg Gly Leu  Glu Xaa Glu Lys Ile  Lys Cys Cys 
    1130                 1135                 1140             


Leu Leu  Leu Asp Ser Val Cys  Ser Xaa Ile Glu Asn  Val Met Ala 
    1145                 1150                 1155             


Xaa Xaa  Leu Pro Gly Leu Leu  Xaa Val Lys His Tyr  Leu Ser Pro 
    1160                 1165                 1170             


Gln Gln  Leu Arg Glu His His  Glu Pro Val Met Ile  Tyr Gln Pro 
    1175                 1180                 1185             


Arg Asp  Phe Phe Arg Ala Gln  Xaa Leu Lys Glu Xaa  Ser Leu Xaa 
    1190                 1195                 1200             


Asn Xaa  Met Gly Gly Tyr Lys  Glu Ser Phe Ser Ser  Ile Met Cys 
    1205                 1210                 1215             


Phe Gly  Cys His Asp Val Tyr  Ser Gln Ala Ser Leu  Gly Met Asp 
    1220                 1225                 1230             


Ile His  Ala Ser Asp Leu Asn  Leu Leu Xaa Arg Arg  Lys Leu Ser 
    1235                 1240                 1245             


Arg Leu  Leu Asp Pro Pro Asp  Pro Leu Gly Lys Asp  Trp Cys Leu 
    1250                 1255                 1260             


Leu Ala  Met Asn Leu Gly Leu  Pro Asp Leu Val Ala  Lys Tyr Asn 
    1265                 1270                 1275             


Xaa Ser  Asn Gly Ala Pro Lys  Asp Phe Leu Pro Ser  Pro Leu His 
    1280                 1285                 1290             


Ala Leu  Leu Arg Glu Trp Xaa  Xaa Tyr Pro Glu Ser  Xaa Val Gly 
    1295                 1300                 1305             


Xaa Leu  Met Ser Lys Leu Arg  Glu Leu Gly Arg Arg  Asp Ala Ala 
    1310                 1315                 1320             


Asp Phe  Leu Leu Lys Ala Ser  Ser Val Phe Lys Ile  Asn Leu Asp 
    1325                 1330                 1335             


Gly Asn  Gly Gln Glu Ala Tyr  Ala Ser Ser Cys Asn  Ser Gly Xaa 
    1340                 1345                 1350             


Ser Tyr  Asn Ser Ile Ser Ser  Val Val Ser Arg 
    1355                 1360                 


<210> 7580
<211> 1430
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (380)..(380)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (517)..(517)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (562)..(562)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (579)..(579)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (640)..(641)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (681)..(681)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (701)..(702)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (781)..(781)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (793)..(793)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (833)..(833)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (908)..(908)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (963)..(963)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1028)..(1028)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1042)..(1042)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1053)..(1053)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1065)..(1065)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1099)..(1099)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1138)..(1138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1161)..(1161)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1203)..(1203)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1218)..(1218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1225)..(1226)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1262)..(1262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1266)..(1266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1269)..(1269)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1309)..(1309)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1345)..(1345)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1366)..(1367)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1372)..(1372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1375)..(1375)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1419)..(1419)
<223> Selenocysteine

<400> 7580
Met Xaa Val Phe Arg Gln Glu Asn Val Asp Asp Tyr Tyr Asp Xaa Gly 
1               5                   10                  15      


Glu Glu Leu Gly Ser Gly Gln Phe Ala Val Val Lys Lys Cys Arg Glu 
            20                  25                  30          


Lys Ser Xaa Gly Leu Gln Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 
        35                  40                  45              


Xaa Lys Ser Ser Arg Arg Gly Val Ser Arg Glu Asp Ile Glu Arg Glu 
    50                  55                  60                  


Val Ser Ile Leu Lys Glu Ile Gln His Pro Asn Val Ile Xaa Leu His 
65                  70                  75                  80  


Glu Val Tyr Glu Asn Lys Xaa Asp Val Ile Leu Ile Leu Glu Leu Val 
                85                  90                  95      


Ala Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Xaa 
            100                 105                 110         


Glu Glu Glu Ala Xaa Glu Phe Leu Lys Gln Ile Leu Asn Gly Val Tyr 
        115                 120                 125             


Tyr Leu His Ser Leu Gln Ile Ala His Phe Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 


Ile Met Leu Leu Asp Arg Asn Val Pro Lys Pro Arg Ile Lys Ile Ile 
145                 150                 155                 160 


Asp Phe Gly Leu Ala His Lys Ile Asp Phe Gly Asn Glu Phe Lys Asn 
                165                 170                 175     


Ile Phe Gly Xaa Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu 
            180                 185                 190         


Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Xaa Tyr 
        195                 200                 205             


Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Asp Xaa Lys Gln Glu 
    210                 215                 220                 


Xaa Leu Ala Asn Val Ser Ala Val Asn Tyr Glu Phe Glu Asp Glu Tyr 
225                 230                 235                 240 


Phe Ser Asn Xaa Ser Ala Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu 
                245                 250                 255     


Val Lys Asp Pro Lys Lys Arg Met Xaa Ile Gln Asp Ser Leu Gln His 
            260                 265                 270         


Pro Trp Ile Lys Pro Lys Asp Xaa Gln Gln Ala Leu Ser Arg Lys Ala 
        275                 280                 285             


Ser Ala Val Asn Met Glu Lys Phe Lys Lys Phe Ala Ala Arg Lys Lys 
    290                 295                 300                 


Trp Lys Gln Ser Val Arg Leu Ile Ser Leu Cys Gln Arg Leu Ser Arg 
305                 310                 315                 320 


Ser Phe Leu Ser Arg Ser Asn Met Ser Val Ala Arg Ser Asp Asp Xaa 
                325                 330                 335     


Leu Asp Glu Glu Asp Ser Phe Val Met Lys Ala Ile Ile His Ala Ile 
            340                 345                 350         


Asn Asp Asp Asn Val Pro Gly Leu Gln His Leu Leu Gly Ser Leu Ser 
        355                 360                 365             


Asn Tyr Asp Val Asn Gln Pro Asn Lys His Gly Xaa Pro Pro Leu Leu 
    370                 375                 380                 


Ile Ala Ala Gly Cys Gly Asn Ile Gln Ile Leu Gln Leu Leu Ile Lys 
385                 390                 395                 400 


Arg Gly Ser Arg Ile Asp Val Gln Asp Lys Gly Gly Ser Asn Ala Val 
                405                 410                 415     


Tyr Trp Ala Ala Arg His Gly His Val Asp Xaa Leu Lys Phe Leu Ser 
            420                 425                 430         


Glu Asn Lys Cys Pro Leu Asp Val Lys Asp Lys Ser Gly Glu Met Ala 
        435                 440                 445             


Leu His Val Ala Ala Arg Tyr Gly His Ala Asp Val Ala Gln Leu Leu 
    450                 455                 460                 


Cys Ser Phe Gly Ser Asn Pro Asn Ile Gln Asp Lys Glu Glu Glu Xaa 
465                 470                 475                 480 


Pro Leu His Cys Ala Ala Trp His Gly Tyr Tyr Ser Val Ala Lys Ala 
                485                 490                 495     


Leu Cys Glu Ala Gly Cys Asn Val Asn Ile Lys Asn Arg Glu Gly Glu 
            500                 505                 510         


Xaa Pro Leu Leu Xaa Ala Ser Ala Arg Gly Tyr His Asp Ile Val Glu 
        515                 520                 525             


Cys Leu Ala Glu His Gly Ala Asp Leu Asn Ala Cys Asp Lys Asp Gly 
    530                 535                 540                 


His Ile Ala Leu His Leu Ala Val Arg Arg Cys Gln Met Glu Val Ile 
545                 550                 555                 560 


Lys Xaa Leu Leu Ser Gln Gly Cys Phe Val Asp Tyr Gln Asp Arg His 
                565                 570                 575     


Gly Asn Xaa Pro Leu His Val Ala Cys Lys Asp Gly Asn Met Pro Ile 
            580                 585                 590         


Val Val Ala Leu Cys Glu Ala Asn Cys Asn Leu Asp Ile Ser Asn Lys 
        595                 600                 605             


Tyr Gly Arg Xaa Pro Leu His Leu Ala Ala Asn Asn Gly Ile Leu Asp 
    610                 615                 620                 


Val Val Arg Tyr Leu Cys Leu Met Gly Ala Ser Val Glu Ala Leu Xaa 
625                 630                 635                 640 


Xaa Asp Gly Lys Xaa Ala Glu Asp Leu Ala Arg Ser Glu Gln His Glu 
                645                 650                 655     


His Val Ala Gly Leu Leu Ala Arg Leu Arg Lys Asp Xaa His Arg Gly 
            660                 665                 670         


Leu Phe Ile Gln Gln Leu Arg Pro Xaa Gln Asn Leu Gln Pro Arg Ile 
        675                 680                 685             


Lys Leu Lys Leu Phe Gly His Ser Gly Ser Gly Lys Xaa Xaa Leu Val 
    690                 695                 700                 


Glu Ser Leu Lys Cys Gly Leu Leu Arg Ser Phe Phe Arg Arg Arg Arg 
705                 710                 715                 720 


Pro Arg Leu Ser Ser Xaa Asn Ser Ser Arg Phe Pro Pro Ser Pro Leu 
                725                 730                 735     


Ala Ser Lys Pro Xaa Val Ser Val Ser Ile Asn Asn Leu Tyr Pro Gly 
            740                 745                 750         


Cys Glu Asn Val Ser Val Arg Ser Arg Ser Met Met Phe Glu Pro Gly 
        755                 760                 765             


Leu Xaa Lys Gly Met Leu Glu Val Phe Val Ala Pro Xaa His His Pro 
    770                 775                 780                 


His Cys Ser Ala Asp Asp Gln Ser Xaa Lys Ala Ile Asp Ile Gln Asn 
785                 790                 795                 800 


Ala Tyr Leu Asn Gly Val Gly Asp Phe Ser Val Trp Glu Phe Ser Gly 
                805                 810                 815     


Asn Pro Val Tyr Phe Cys Cys Tyr Asp Tyr Phe Ala Ala Asn Asp Pro 
            820                 825                 830         


Xaa Ser Ile His Val Val Val Phe Ser Leu Glu Glu Pro Tyr Glu Ile 
        835                 840                 845             


Gln Leu Asn Gln Val Ile Phe Trp Leu Ser Phe Leu Lys Ser Leu Val 
    850                 855                 860                 


Pro Val Glu Glu Pro Ile Ala Phe Gly Gly Lys Leu Lys Asn Pro Leu 
865                 870                 875                 880 


Gln Val Val Leu Val Ala Xaa His Ala Asp Ile Met Asn Val Pro Arg 
                885                 890                 895     


Pro Ala Gly Gly Glu Phe Gly Tyr Asp Lys Asp Xaa Ser Leu Leu Lys 
            900                 905                 910         


Glu Ile Arg Asn Arg Phe Gly Asn Asp Leu His Ile Ser Asn Lys Leu 
        915                 920                 925             


Phe Val Leu Asp Ala Gly Ala Ser Gly Ser Lys Asp Met Lys Val Leu 
    930                 935                 940                 


Arg Asn His Leu Gln Glu Ile Arg Ser Gln Ile Val Ser Val Cys Pro 
945                 950                 955                 960 


Pro Met Xaa His Leu Cys Glu Lys Ile Ile Ser Xaa Leu Pro Ser Trp 
                965                 970                 975     


Arg Lys Leu Asn Gly Pro Asn Gln Leu Met Ser Leu Gln Gln Phe Val 
            980                 985                 990         


Tyr Asp Val Gln Asp Gln Leu Asn  Pro Leu Ala Ser Glu  Glu Asp Leu 
        995                 1000                 1005             


Arg Arg  Ile Ala Gln Gln Leu  His Ser Xaa Gly Glu  Ile Asn Ile 
    1010                 1015                 1020             


Met Gln  Ser Glu Xaa Val Gln  Asp Val Leu Leu Leu  Asp Pro Arg 
    1025                 1030                 1035             


Trp Leu  Cys Xaa Asn Val Leu  Gly Lys Leu Leu Ser  Val Glu Xaa 
    1040                 1045                 1050             


Pro Arg  Ala Leu His His Tyr  Arg Gly Arg Tyr Xaa  Val Glu Asp 
    1055                 1060                 1065             


Ile Gln  Arg Leu Val Pro Asp  Ser Asp Val Glu Glu  Leu Leu Gln 
    1070                 1075                 1080             


Ile Leu  Asp Ala Met Asp Ile  Cys Ala Arg Asp Leu  Ser Ser Gly 
    1085                 1090                 1095             


Xaa Met  Val Asp Val Pro Ala  Leu Ile Lys Xaa Asp  Asn Leu His 
    1100                 1105                 1110             


Arg Ser  Trp Ala Asp Glu Glu  Asp Glu Val Met Val  Tyr Gly Gly 
    1115                 1120                 1125             


Val Arg  Ile Val Pro Val Glu  His Leu Xaa Pro Phe  Pro Cys Gly 
    1130                 1135                 1140             


Ile Phe  His Lys Val Gln Val  Asn Leu Cys Arg Trp  Ile His Gln 
    1145                 1150                 1155             


Gln Ser  Xaa Glu Gly Asp Ala  Asp Ile Arg Leu Trp  Val Asn Gly 
    1160                 1165                 1170             


Cys Lys  Leu Ala Asn Arg Gly  Ala Glu Leu Leu Val  Leu Leu Val 
    1175                 1180                 1185             


Asn His  Gly Gln Gly Ile Glu  Val Gln Val Arg Gly  Leu Glu Xaa 
    1190                 1195                 1200             


Glu Lys  Ile Lys Cys Cys Leu  Leu Leu Asp Ser Val  Cys Ser Xaa 
    1205                 1210                 1215             


Ile Glu  Asn Val Met Ala Xaa  Xaa Leu Pro Gly Leu  Leu Xaa Val 
    1220                 1225                 1230             


Lys His  Tyr Leu Ser Pro Gln  Gln Leu Arg Glu His  His Glu Pro 
    1235                 1240                 1245             


Val Met  Ile Tyr Gln Pro Arg  Asp Phe Phe Arg Ala  Gln Xaa Leu 
    1250                 1255                 1260             


Lys Glu  Xaa Ser Leu Xaa Asn  Xaa Met Gly Gly Tyr  Lys Glu Ser 
    1265                 1270                 1275             


Phe Ser  Ser Ile Met Cys Phe  Gly Cys His Asp Val  Tyr Ser Gln 
    1280                 1285                 1290             


Ala Ser  Leu Gly Met Asp Ile  His Ala Ser Asp Leu  Asn Leu Leu 
    1295                 1300                 1305             


Xaa Arg  Arg Lys Leu Ser Arg  Leu Leu Asp Pro Pro  Asp Pro Leu 
    1310                 1315                 1320             


Gly Lys  Asp Trp Cys Leu Leu  Ala Met Asn Leu Gly  Leu Pro Asp 
    1325                 1330                 1335             


Leu Val  Ala Lys Tyr Asn Xaa  Ser Asn Gly Ala Pro  Lys Asp Phe 
    1340                 1345                 1350             


Leu Pro  Ser Pro Leu His Ala  Leu Leu Arg Glu Trp  Xaa Xaa Tyr 
    1355                 1360                 1365             


Pro Glu  Ser Xaa Val Gly Xaa  Leu Met Ser Lys Leu  Arg Glu Leu 
    1370                 1375                 1380             


Gly Arg  Arg Asp Ala Ala Asp  Phe Leu Leu Lys Ala  Ser Ser Val 
    1385                 1390                 1395             


Phe Lys  Ile Asn Leu Asp Gly  Asn Gly Gln Glu Ala  Tyr Ala Ser 
    1400                 1405                 1410             


Ser Cys  Asn Ser Gly Xaa Ser  Tyr Asn Ser Ile Ser  Ser Val Val 
    1415                 1420                 1425             


Ser Arg  
    1430 


<210> 7581
<211> 188
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<400> 7581
Met Xaa Val Phe Arg Gln Glu Asn Val Asp Asp Tyr Tyr Asp Xaa Gly 
1               5                   10                  15      


Glu Glu Leu Gly Ser Gly Gln Phe Ala Val Val Lys Lys Cys Arg Glu 
            20                  25                  30          


Lys Ser Xaa Gly Leu Gln Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 
        35                  40                  45              


Xaa Lys Ser Ser Arg Arg Gly Val Ser Arg Glu Asp Ile Glu Arg Glu 
    50                  55                  60                  


Val Ser Ile Leu Lys Glu Ile Gln His Pro Asn Val Ile Xaa Leu His 
65                  70                  75                  80  


Glu Val Tyr Glu Asn Lys Xaa Asp Val Ile Leu Ile Leu Glu Leu Val 
                85                  90                  95      


Ala Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Xaa 
            100                 105                 110         


Glu Glu Glu Ala Xaa Glu Phe Leu Lys Gln Ile Leu Asn Gly Val Tyr 
        115                 120                 125             


Tyr Leu His Ser Leu Gln Ile Ala His Phe Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 


Ile Met Leu Leu Asp Arg Asn Val Pro Lys Pro Arg Ile Lys Ile Ile 
145                 150                 155                 160 


Asp Phe Gly Leu Ala His Lys Ile Asp Phe Gly Asn Glu Phe Lys Asn 
                165                 170                 175     


Ile Phe Gly Xaa Pro Glu Phe Val Gly Val Ser Gly 
            180                 185             


<210> 7582
<211> 88
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Selenocysteine

<400> 7582
Met Phe Gln Ala Ser Met Arg Ser Pro Asn Met Glu Pro Phe Lys Gln 
1               5                   10                  15      


Gln Lys Val Glu Asp Phe Tyr Asp Ile Gly Glu Glu Leu Gly Arg Phe 
            20                  25                  30          


Leu Ala Gly Ile Leu Leu Phe Gln Xaa Leu His Leu Leu Leu Xaa Leu 
        35                  40                  45              


Leu Leu Leu Pro Ala Cys Phe Ser Leu Leu Ser Cys Pro Ser Ser Ser 
    50                  55                  60                  


Gln Arg Xaa Ala His Leu Ala Leu Trp Pro Val Cys His Arg Glu Glu 
65                  70                  75                  80  


Val Pro Gly Glu Glu His Gly Ala 
                85              


<210> 7583
<211> 91
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Selenocysteine

<400> 7583
Met Phe Gln Ala Ser Met Arg Ser Pro Asn Met Glu Pro Phe Lys Gln 
1               5                   10                  15      


Gln Lys Val Glu Asp Phe Tyr Asp Ile Gly Glu Glu Leu Gly Ser Gly 
            20                  25                  30          


Gln Phe Ala Ile Val Lys Lys Cys Arg Glu Lys Ser Xaa Gly Leu Glu 
        35                  40                  45              


Tyr Ala Ala Lys Phe Ile Lys Lys Arg Gln Ser Arg Ala Ser Arg Arg 
    50                  55                  60                  


Gly Val Ser Arg Glu Glu Ile Glu Arg Glu Ser Val Trp Arg Arg Ala 
65                  70                  75                  80  


Leu Arg Phe Pro Gly Pro Glu Gly Val Xaa Glu 
                85                  90      


<210> 7584
<211> 81
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<400> 7584
Met Phe Gln Ala Ser Met Arg Ser Pro Asn Met Glu Pro Phe Lys Gln 
1               5                   10                  15      


Gln Lys Val Glu Asp Phe Tyr Asp Ile Gly Glu Glu Leu Gly Ser Gly 
            20                  25                  30          


Gln Phe Ala Ile Val Lys Lys Cys Arg Glu Lys Ser Xaa Gly Leu Glu 
        35                  40                  45              


Tyr Ala Ala Lys Phe Ile Lys Lys Arg Gln Ser Arg Ala Ser Arg Arg 
    50                  55                  60                  


Gly Val Ser Arg Glu Glu Ile Glu Arg Glu Val Ser Ile Leu Arg Gln 
65                  70                  75                  80  


Val 
    


<210> 7585
<211> 370
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Selenocysteine

<400> 7585
Met Phe Gln Ala Ser Met Arg Ser Pro Asn Met Glu Pro Phe Lys Gln 
1               5                   10                  15      


Gln Lys Val Glu Asp Phe Tyr Asp Ile Gly Glu Glu Leu Gly Ser Gly 
            20                  25                  30          


Gln Phe Ala Ile Val Lys Lys Cys Arg Glu Lys Ser Xaa Gly Leu Glu 
        35                  40                  45              


Tyr Ala Ala Lys Phe Ile Lys Lys Arg Gln Ser Arg Ala Ser Arg Arg 
    50                  55                  60                  


Gly Val Ser Arg Glu Glu Ile Glu Arg Glu Val Ser Ile Leu Arg Gln 
65                  70                  75                  80  


Val Leu His His Asn Val Ile Xaa Leu His Asp Val Tyr Glu Asn Arg 
                85                  90                  95      


Xaa Asp Val Val Leu Ile Leu Glu Leu Val Ser Gly Gly Glu Leu Phe 
            100                 105                 110         


Asp Phe Leu Ala Gln Lys Glu Ser Leu Ser Glu Glu Glu Ala Xaa Ser 
        115                 120                 125             


Phe Ile Lys Gln Ile Leu Asp Gly Val Asn Tyr Leu His Xaa Lys Lys 
    130                 135                 140                 


Ile Ala His Phe Asp Leu Lys Pro Glu Asn Ile Met Leu Leu Asp Lys 
145                 150                 155                 160 


Asn Ile Pro Ile Pro His Ile Lys Leu Ile Asp Phe Gly Leu Ala His 
                165                 170                 175     


Glu Ile Glu Asp Gly Val Glu Phe Lys Asn Ile Phe Gly Xaa Pro Glu 
            180                 185                 190         


Phe Val Ala Pro Glu Ile Val Asn Tyr Glu Pro Leu Gly Leu Glu Ala 
        195                 200                 205             


Asp Met Trp Ser Ile Gly Val Ile Xaa Tyr Ile Leu Leu Ser Gly Ala 
    210                 215                 220                 


Ser Pro Phe Leu Gly Asp Xaa Lys Gln Glu Xaa Leu Ala Asn Ile Xaa 
225                 230                 235                 240 


Ala Val Ser Tyr Asp Phe Asp Glu Glu Phe Phe Ser Gln Xaa Ser Glu 
                245                 250                 255     


Leu Ala Lys Asp Phe Ile Arg Lys Leu Leu Val Lys Glu Xaa Arg Lys 
            260                 265                 270         


Arg Leu Xaa Ile Gln Glu Ala Leu Arg His Pro Trp Ile Xaa Pro Val 
        275                 280                 285             


Asp Asn Gln Gln Ala Met Val Arg Arg Glu Ser Val Val Asn Leu Glu 
    290                 295                 300                 


Asn Phe Arg Lys Gln Tyr Val Arg Arg Arg Trp Lys Leu Ser Phe Ser 
305                 310                 315                 320 


Ile Val Ser Leu Cys Asn His Leu Xaa Arg Ser Leu Met Lys Lys Val 
                325                 330                 335     


His Leu Arg Pro Asp Glu Asp Leu Arg Asn Cys Glu Ser Asp Xaa Glu 
            340                 345                 350         


Glu Asp Ile Ala Arg Arg Lys Ala Leu His Pro Arg Arg Arg Ser Ser 
        355                 360                 365             


Xaa Ser 
    370 


<210> 7586
<211> 488
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (231)..(231)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (302)..(302)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<400> 7586
Met Phe Gln Ala Ser Met Arg Ser Pro Asn Met Glu Pro Phe Lys Gln 
1               5                   10                  15      


Gln Lys Val Glu Asp Phe Tyr Asp Ile Gly Glu Glu Leu Gly Ser Gly 
            20                  25                  30          


Gln Phe Ala Ile Val Lys Lys Cys Arg Glu Lys Ser Xaa Gly Leu Glu 
        35                  40                  45              


Tyr Ala Ala Lys Phe Ile Lys Lys Arg Gln Ser Arg Ala Ser Arg Arg 
    50                  55                  60                  


Gly Val Ser Arg Glu Glu Ile Glu Arg Glu Val Ser Ile Leu Arg Gln 
65                  70                  75                  80  


Val Leu His His Asn Val Ile Xaa Leu His Asp Val Tyr Glu Asn Arg 
                85                  90                  95      


Xaa Asp Val Val Leu Ile Leu Glu Leu Val Ser Gly Gly Glu Leu Phe 
            100                 105                 110         


Asp Phe Leu Ala Gln Lys Glu Ser Leu Ser Glu Glu Glu Ala Xaa Ser 
        115                 120                 125             


Phe Ile Lys Gln Ile Leu Asp Gly Val Asn Tyr Leu His Xaa Lys Lys 
    130                 135                 140                 


Ile Ala His Phe Asp Leu Lys Pro Glu Asn Ile Met Leu Leu Asp Lys 
145                 150                 155                 160 


Asn Ile Pro Ile Pro His Ile Lys Leu Ile Asp Phe Gly Leu Ala His 
                165                 170                 175     


Glu Ile Glu Asp Gly Val Glu Phe Lys Asn Ile Phe Gly Xaa Pro Glu 
            180                 185                 190         


Phe Val Ala Pro Glu Ile Val Asn Tyr Glu Pro Leu Gly Leu Glu Ala 
        195                 200                 205             


Asp Met Trp Ser Ile Gly Val Ile Xaa Tyr Ile Leu Leu Ser Gly Ala 
    210                 215                 220                 


Ser Pro Phe Leu Gly Asp Xaa Lys Gln Glu Xaa Leu Ala Asn Ile Xaa 
225                 230                 235                 240 


Ala Val Ser Tyr Asp Phe Asp Glu Glu Phe Phe Ser Gln Xaa Ser Glu 
                245                 250                 255     


Leu Ala Lys Asp Phe Ile Arg Lys Leu Leu Val Lys Glu Xaa Arg Lys 
            260                 265                 270         


Arg Leu Xaa Ile Gln Glu Ala Leu Arg His Pro Trp Ile Xaa Ser Lys 
        275                 280                 285             


Gly Glu Gly Arg Ala Pro Glu Gln Arg Lys Xaa Glu Pro Xaa Gln Leu 
    290                 295                 300                 


Lys Xaa Lys His Leu Arg Glu Tyr Xaa Leu Lys Cys His Ser Ser Met 
305                 310                 315                 320 


Pro Pro Asn Asn Ser Tyr Val Asn Phe Glu Arg Phe Ala Cys Val Val 
                325                 330                 335     


Glu Asp Val Ala Arg Val Asp Leu Gly Cys Arg Ala Leu Val Glu Ala 
            340                 345                 350         


His Asp Xaa Ile Gln Asp Asp Val Glu Ala Leu Val Ser Ile Phe Asn 
        355                 360                 365             


Glu Lys Glu Ala Trp Tyr Arg Glu Glu Asn Glu Ser Ala Arg His Asp 
    370                 375                 380                 


Leu Ser Gln Leu Arg Tyr Glu Phe Arg Lys Val Glu Ser Leu Lys Lys 
385                 390                 395                 400 


Leu Leu Arg Glu Asp Ile Gln Ala Xaa Gly Cys Ser Leu Gly Ser Met 
                405                 410                 415     


Ala Arg Lys Leu Asp His Leu Gln Ala Gln Phe Glu Ile Leu Arg Gln 
            420                 425                 430         


Glu Leu Ser Ala Asp Leu Gln Trp Ile Gln Glu Leu Val Gly Ser Phe 
        435                 440                 445             


Gln Leu Glu Ser Gly Ser Ser Glu Gly Leu Gly Ser Xaa Phe Tyr Gln 
    450                 455                 460                 


Asp Xaa Ser Glu Ser Leu Ser Glu Leu Leu Ser Arg Ser Cys Xaa Glu 
465                 470                 475                 480 


Glu Phe Leu Ala Gly Trp Lys Leu 
                485             


<210> 7587
<211> 48
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Selenocysteine

<400> 7587
Met Lys Lys Val His Leu Arg Pro Asp Glu Asp Leu Xaa Glu Phe His 
1               5                   10                  15      


Ser Tyr Cys Leu Gly Trp Ser Ala Met Ala Arg Ser Arg Leu Xaa Ala 
            20                  25                  30          


Xaa Ser Ala Ser Trp Leu Gln Ala Ile Leu Leu Arg Gln Pro Pro Glu 
        35                  40                  45              


<210> 7588
<211> 141
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 7588
Met Ser Xaa Phe Arg Gln Glu Asp Val Glu Asp His Tyr Glu Met Gly 
1               5                   10                  15      


Glu Glu Leu Gly Ser Gly Gln Phe Ala Ile Val Arg Lys Cys Arg Gln 
            20                  25                  30          


Lys Gly Xaa Gly Lys Glu Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 
        35                  40                  45              


Leu Ser Ser Ser Arg Arg Gly Val Ser Arg Glu Glu Ile Glu Arg Glu 
    50                  55                  60                  


Val Asn Ile Leu Arg Glu Ile Arg His Pro Asn Ile Ile Xaa Leu His 
65                  70                  75                  80  


Asp Ile Phe Glu Asn Lys Xaa Asp Val Val Leu Ile Leu Glu Leu Val 
                85                  90                  95      


Ser Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Xaa 
            100                 105                 110         


Glu Asp Glu Ala Xaa Gln Phe Leu Lys Gln Ile Leu Asp Gly Val His 
        115                 120                 125             


Tyr Leu His Ser Lys Arg Ile Ala His Phe Asp Leu Lys 
    130                 135                 140     


<210> 7589
<211> 158
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<400> 7589
Met Ser Xaa Phe Arg Gln Glu Asp Val Glu Asp His Tyr Glu Met Gly 
1               5                   10                  15      


Glu Glu Leu Gly Ser Gly Gln Phe Ala Ile Val Arg Lys Cys Arg Gln 
            20                  25                  30          


Lys Gly Xaa Gly Lys Glu Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 
        35                  40                  45              


Leu Ser Ser Ser Arg Arg Gly Val Ser Arg Glu Glu Ile Glu Arg Glu 
    50                  55                  60                  


Val Asn Ile Leu Arg Glu Ile Arg His Pro Asn Ile Ile Xaa Leu His 
65                  70                  75                  80  


Asp Ile Phe Glu Asn Lys Xaa Asp Val Val Leu Ile Leu Glu Leu Val 
                85                  90                  95      


Ser Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Xaa 
            100                 105                 110         


Glu Asp Glu Ala Xaa Gln Phe Leu Lys Gln Ile Leu Asp Gly Val His 
        115                 120                 125             


Tyr Leu His Ser Lys Arg Ile Ala His Phe Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 


Ile Met Leu Leu Asp Lys Asn Val Pro Asn Pro Arg Ile Lys 
145                 150                 155             


<210> 7590
<211> 454
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (299)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (306)..(306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Selenocysteine

<400> 7590
Met Ser Xaa Phe Arg Gln Glu Asp Val Glu Asp His Tyr Glu Met Gly 
1               5                   10                  15      


Glu Glu Leu Gly Ser Gly Gln Phe Ala Ile Val Arg Lys Cys Arg Gln 
            20                  25                  30          


Lys Gly Xaa Gly Lys Glu Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 
        35                  40                  45              


Leu Ser Ser Ser Arg Arg Gly Val Ser Arg Glu Glu Ile Glu Arg Glu 
    50                  55                  60                  


Val Asn Ile Leu Arg Glu Ile Arg His Pro Asn Ile Ile Xaa Leu His 
65                  70                  75                  80  


Asp Ile Phe Glu Asn Lys Xaa Asp Val Val Leu Ile Leu Glu Leu Val 
                85                  90                  95      


Ser Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Xaa 
            100                 105                 110         


Glu Asp Glu Ala Xaa Gln Phe Leu Lys Gln Ile Leu Asp Gly Val His 
        115                 120                 125             


Tyr Leu His Ser Lys Arg Ile Ala His Phe Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 


Ile Met Leu Leu Asp Lys Asn Val Pro Asn Pro Arg Ile Lys Leu Ile 
145                 150                 155                 160 


Asp Phe Gly Ile Ala His Lys Ile Glu Ala Gly Asn Glu Phe Lys Asn 
                165                 170                 175     


Ile Phe Gly Xaa Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu 
            180                 185                 190         


Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Xaa Tyr 
        195                 200                 205             


Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Glu Xaa Lys Gln Glu 
    210                 215                 220                 


Xaa Leu Xaa Asn Ile Ser Ala Val Asn Tyr Asp Phe Asp Glu Glu Tyr 
225                 230                 235                 240 


Phe Ser Asn Xaa Ser Glu Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu 
                245                 250                 255     


Val Lys Asp Pro Lys Arg Arg Met Xaa Ile Ala Gln Ser Leu Glu His 
            260                 265                 270         


Ser Trp Ile Lys Ala Ile Arg Arg Arg Asn Val Arg Gly Glu Asp Ser 
        275                 280                 285             


Gly Arg Lys Pro Glu Arg Arg Arg Leu Lys Xaa Xaa Arg Leu Lys Glu 
    290                 295                 300                 


Tyr Xaa Ile Lys Ser His Ser Ser Leu Pro Pro Asn Asn Ser Tyr Ala 
305                 310                 315                 320 


Asp Phe Glu Arg Phe Ser Lys Val Leu Glu Glu Ala Ala Ala Ala Glu 
                325                 330                 335     


Glu Gly Leu Arg Glu Leu Gln Arg Ser Arg Arg Leu Cys His Glu Asp 
            340                 345                 350         


Val Glu Ala Leu Ala Ala Ile Tyr Glu Glu Lys Glu Ala Trp Tyr Arg 
        355                 360                 365             


Glu Glu Ser Asp Ser Leu Gly Gln Asp Leu Arg Arg Leu Arg Gln Glu 
    370                 375                 380                 


Leu Leu Lys Xaa Glu Ala Leu Lys Arg Gln Ala Gln Glu Glu Ala Lys 
385                 390                 395                 400 


Gly Ala Leu Leu Gly Xaa Ser Gly Leu Lys Arg Arg Phe Ser Arg Leu 
                405                 410                 415     


Glu Asn Arg Tyr Glu Ala Leu Ala Lys Gln Val Ala Ser Glu Met Arg 
            420                 425                 430         


Phe Val Gln Asp Leu Val Arg Ala Leu Glu Gln Glu Lys Leu Gln Gly 
        435                 440                 445             


Val Glu Cys Gly Leu Arg 
    450                 


<210> 7591
<211> 92
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<400> 7591
Xaa Ser Gly Ala Ser Pro Phe Leu Gly Glu Xaa Lys Gln Glu Xaa Leu 
1               5                   10                  15      


Xaa Asn Ile Ser Ala Val Asn Tyr Asp Phe Asp Glu Glu Tyr Phe Ser 
            20                  25                  30          


Asn Xaa Ser Glu Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu Val Lys 
        35                  40                  45              


Asp Pro Lys Arg Arg Met Xaa Ile Ala Gln Ser Leu Glu His Ser Trp 
    50                  55                  60                  


Ile Lys Val Ser Gly Glu Val Gly Glu Leu Pro Gly Leu Pro Ala Leu 
65                  70                  75                  80  


Ala Phe Ser Leu Gly Ser Arg Gly Ala Phe Ser Ile 
                85                  90          


<210> 7592
<211> 113
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<400> 7592
Met Ala Asn Glu Val Gln Asp Leu Leu Ser Pro Arg Lys Gly Gly His 
1               5                   10                  15      


Pro Pro Ala Val Lys Ala Gly Gly Met Arg Ile Ser Lys Lys Gln Glu 
            20                  25                  30          


Ile Gly Xaa Leu Glu Arg His Xaa Lys Lys Xaa Gly Phe Glu Lys Xaa 
        35                  40                  45              


Ser Ala Ile Ala Asn Val Ala Lys Ile Gln Xaa Leu Asp Ala Leu Asn 
    50                  55                  60                  


Asp Ala Leu Glu Lys Glu Gln Val Gln Leu Gly Val Arg Asn Glu Arg 
65                  70                  75                  80  


Gln Val Gln Pro Phe His His Gly Cys Ser Trp Lys Glu Xaa Ser Gly 
                85                  90                  95      


Phe Asp Xaa Arg Cys Pro Arg His Xaa Glu Pro Arg Asn Leu Xaa Gly 
            100                 105                 110         


Val 
    


<210> 7593
<211> 199
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (154)..(155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<400> 7593
Met Ala Asn Glu Val Gln Asp Leu Leu Ser Pro Arg Lys Gly Gly His 
1               5                   10                  15      


Pro Pro Ala Val Lys Ala Gly Gly Met Arg Ile Ser Lys Lys Gln Glu 
            20                  25                  30          


Ile Gly Xaa Leu Glu Arg His Xaa Lys Lys Xaa Gly Phe Glu Lys Xaa 
        35                  40                  45              


Ser Ala Ile Ala Asn Val Ala Lys Ile Gln Xaa Leu Asp Ala Leu Asn 
    50                  55                  60                  


Asp Ala Leu Glu Lys Glu Gln Val Gln Leu Gly Val Arg Asn Glu Arg 
65                  70                  75                  80  


Gln Val Gln Pro Phe His His Gly Cys Ser Trp Lys Glu Xaa Ser Gly 
                85                  90                  95      


Phe Asp Xaa Arg Ser Ser Glu Asp Pro Glu Arg Leu Phe Leu Ser Met 
            100                 105                 110         


Cys Leu Val Xaa Val Leu Gly Asn Leu Leu Ile Ile Leu Ala Val Xaa 
        115                 120                 125             


Pro Asp Ser His Leu His Ile Pro Met Tyr Phe Phe Leu Ser Asn Leu 
    130                 135                 140                 


Ser Leu Pro Asp Ile Gly Phe Xaa Ser Xaa Xaa Val Pro Lys Met Ile 
145                 150                 155                 160 


Val Asp Ile Gln Ser His Ser Arg Val Ile Ser Tyr Ala Gly Cys Leu 
                165                 170                 175     


Xaa Gln Met Ser Leu Phe Ala Ile Phe Gly Gly Met Glu Glu Arg His 
            180                 185                 190         


Ala Pro Glu Cys Asp Gly Leu 
        195                 


<210> 7594
<211> 107
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Selenocysteine

<400> 7594
Met Ala Asn Glu Val Gln Asp Leu Leu Ser Pro Arg Lys Gly Gly His 
1               5                   10                  15      


Pro Pro Ala Val Lys Ala Gly Gly Met Arg Ile Ser Lys Lys Gln Glu 
            20                  25                  30          


Ile Gly Xaa Leu Glu Arg His Xaa Lys Lys Xaa Gly Phe Glu Lys Xaa 
        35                  40                  45              


Ser Ala Ile Ala Asn Val Ala Lys Ile Gln Xaa Leu Asp Ala Leu Asn 
    50                  55                  60                  


Asp Ala Leu Glu Lys Leu Asn Tyr Lys Phe Pro Ala Xaa Val His Met 
65                  70                  75                  80  


Ala His Gln Lys Pro Xaa Pro Ala Leu Glu Lys Val Val Pro Leu Lys 
                85                  90                  95      


Arg Ile Tyr Ile Ile Gln Gln Pro Arg Lys Cys 
            100                 105         


<210> 7595
<211> 134
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<400> 7595
Met Ala Asn Glu Val Gln Asp Leu Leu Ser Pro Arg Lys Gly Gly His 
1               5                   10                  15      


Pro Pro Ala Val Lys Ala Gly Gly Met Arg Ile Ser Lys Lys Gln Glu 
            20                  25                  30          


Ile Gly Xaa Leu Glu Arg His Xaa Lys Lys Xaa Gly Phe Glu Lys Xaa 
        35                  40                  45              


Ser Ala Ile Ala Asn Val Ala Lys Ile Gln Xaa Leu Asp Ala Leu Asn 
    50                  55                  60                  


Asp Ala Leu Glu Lys Ser Phe Ala Leu Phe Ala Gln Ala Gly Lys Gln 
65                  70                  75                  80  


Trp Ser Asp Leu Ser Ser Leu Gln Pro Pro Pro Pro Gly Phe Lys Trp 
                85                  90                  95      


Phe Ser Cys Leu Ser Leu Pro Ser Ser Trp Asp Tyr Ser Ser Xaa Ile 
            100                 105                 110         


Asn Phe Gln Gln Gln Cys Xaa Trp Arg Ile Lys Asn Pro His Leu Leu 
        115                 120                 125             


Trp Lys Arg Leu Phe His 
    130                 


<210> 7596
<211> 174
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (127)..(127)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (129)..(130)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Selenocysteine

<400> 7596
Xaa Arg Ile Ser Lys Lys Gln Glu Ile Gly Xaa Leu Glu Arg His Xaa 
1               5                   10                  15      


Lys Lys Xaa Gly Phe Glu Lys Xaa Ser Ala Ile Ala Asn Val Ala Lys 
            20                  25                  30          


Ile Gln Xaa Leu Asp Ala Leu Asn Asp Ala Leu Glu Lys Glu Gln Val 
        35                  40                  45              


Gln Leu Gly Val Arg Asn Glu Arg Gln Val Gln Pro Phe His His Gly 
    50                  55                  60                  


Cys Ser Trp Lys Glu Xaa Ser Gly Phe Asp Xaa Ser Ser Glu Asp Pro 
65                  70                  75                  80  


Glu Arg Leu Phe Leu Ser Met Cys Leu Val Xaa Val Leu Gly Asn Leu 
                85                  90                  95      


Leu Ile Ile Leu Ala Val Xaa Pro Asp Ser His Leu His Ile Pro Met 
            100                 105                 110         


Tyr Phe Phe Leu Ser Asn Leu Ser Leu Pro Asp Ile Gly Phe Xaa Ser 
        115                 120                 125             


Xaa Xaa Val Pro Lys Met Ile Val Asp Ile Gln Ser His Ser Arg Val 
    130                 135                 140                 


Ile Ser Tyr Ala Gly Cys Leu Xaa Gln Met Ser Leu Phe Ala Ile Phe 
145                 150                 155                 160 


Gly Gly Met Glu Glu Arg His Ala Pro Glu Cys Asp Gly Leu 
                165                 170                 


<210> 7597
<211> 263
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<400> 7597
Met Gly Arg Ala Glu Leu Leu Glu Gly Lys Met Ser Xaa Gln Asp Pro 
1               5                   10                  15      


Ser Asp Leu Trp Ser Arg Ser Asp Gly Glu Ala Glu Leu Leu Gln Asp 
            20                  25                  30          


Leu Gly Trp Tyr His Gly Asn Leu Xaa Arg His Ala Ala Glu Ala Leu 
        35                  40                  45              


Leu Leu Ser Asn Gly Cys Asp Gly Ser Tyr Leu Leu Arg Asp Ser Asn 
    50                  55                  60                  


Glu Xaa Xaa Gly Leu Tyr Ser Leu Ser Val Arg Ala Lys Asp Ser Val 
65                  70                  75                  80  


Lys His Phe His Val Glu Tyr Xaa Gly Tyr Ser Phe Lys Phe Gly Phe 
                85                  90                  95      


Asn Glu Phe Ser Ser Leu Lys Asp Phe Val Lys His Phe Ala Asn Gln 
            100                 105                 110         


Pro Leu Ile Gly Ser Glu Xaa Gly Xaa Leu Met Val Leu Lys His Pro 
        115                 120                 125             


Tyr Pro Arg Lys Val Glu Glu Pro Ser Ile Tyr Glu Ser Val Arg Val 
    130                 135                 140                 


His Xaa Ala Met Gln Xaa Gly Arg Xaa Glu Asp Asp Leu Val Pro Xaa 
145                 150                 155                 160 


Ala Pro Ser Leu Gly Xaa Lys Glu Gly Tyr Leu Xaa Lys Gln Gly Gly 
                165                 170                 175     


Leu Val Lys Xaa Trp Lys Xaa Arg Trp Phe Xaa Leu His Arg Asn Glu 
            180                 185                 190         


Leu Lys Tyr Phe Lys Asp Gln Met Ser Pro Glu Pro Ile Arg Ile Leu 
        195                 200                 205             


Asp Leu Xaa Glu Cys Ser Ala Val Gln Phe Asp Tyr Ser Gln Glu Arg 
    210                 215                 220                 


Val Asn Cys Phe Cys Leu Val Phe Pro Phe Arg Xaa Phe Tyr Leu Cys 
225                 230                 235                 240 


Ala Lys Xaa Gly Val Glu Ala Asp Glu Trp Ile Lys Ile Leu Arg Trp 
                245                 250                 255     


Lys Leu Val Lys Asp Lys Ser 
            260             


<210> 7598
<211> 280
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (66)..(67)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (146)..(146)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (160)..(160)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (180)..(180)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (183)..(183)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<400> 7598
Met Gly Arg Ala Glu Leu Leu Glu Gly Lys Met Ser Xaa Gln Asp Pro 
1               5                   10                  15      


Ser Asp Leu Trp Ser Arg Ser Asp Gly Glu Ala Glu Leu Leu Gln Asp 
            20                  25                  30          


Leu Gly Trp Tyr His Gly Asn Leu Xaa Arg His Ala Ala Glu Ala Leu 
        35                  40                  45              


Leu Leu Ser Asn Gly Cys Asp Gly Ser Tyr Leu Leu Arg Asp Ser Asn 
    50                  55                  60                  


Glu Xaa Xaa Gly Leu Tyr Ser Leu Ser Val Arg Ala Lys Asp Ser Val 
65                  70                  75                  80  


Lys His Phe His Val Glu Tyr Xaa Gly Tyr Ser Phe Lys Phe Gly Phe 
                85                  90                  95      


Asn Glu Phe Ser Ser Leu Lys Asp Phe Val Lys His Phe Ala Asn Gln 
            100                 105                 110         


Pro Leu Ile Gly Ser Glu Xaa Gly Xaa Leu Met Val Leu Lys His Pro 
        115                 120                 125             


Tyr Pro Arg Lys Val Glu Glu Pro Ser Ile Tyr Glu Ser Val Arg Val 
    130                 135                 140                 


His Xaa Ala Met Gln Xaa Gly Arg Xaa Glu Asp Asp Leu Val Pro Xaa 
145                 150                 155                 160 


Ala Pro Ser Leu Gly Xaa Lys Glu Gly Tyr Leu Xaa Lys Gln Gly Gly 
                165                 170                 175     


Leu Val Lys Xaa Trp Lys Xaa Arg Trp Phe Xaa Leu His Arg Asn Glu 
            180                 185                 190         


Leu Lys Tyr Phe Lys Asp Gln Met Ser Pro Glu Pro Ile Arg Ile Leu 
        195                 200                 205             


Asp Leu Xaa Glu Cys Ser Ala Val Gln Phe Asp Tyr Ser Gln Glu Arg 
    210                 215                 220                 


Val Asn Cys Phe Cys Leu Val Phe Pro Phe Arg Xaa Phe Tyr Leu Cys 
225                 230                 235                 240 


Ala Lys Xaa Gly Val Glu Ala Asp Glu Trp Ile Lys Ile Leu Arg Trp 
                245                 250                 255     


Lys Leu Ser Gln Ile Arg Lys Gln Leu Asn Gln Gly Glu Gly Xaa Ile 
            260                 265                 270         


Arg Ser Arg Ser Phe Ile Phe Lys 
        275                 280 


<210> 7599
<211> 48
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<400> 7599
Met Ala Xaa Ala Asn Ser Ile Ile Val Leu Asp Asp Asp Asp Glu Asp 
1               5                   10                  15      


Glu Ala Ala Ala Gln Pro Gly Pro Ser His Pro Leu Pro Asn Ala Ala 
            20                  25                  30          


Ser Pro Gly Ala Glu Ala Pro Ser Ser Ser Glu Pro His Gly Ala Arg 
        35                  40                  45              


<210> 7600
<211> 130
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<400> 7600
Met Ala Xaa Ala Asn Ser Ile Ile Val Leu Asp Asp Asp Asp Glu Asp 
1               5                   10                  15      


Glu Ala Ala Ala Gln Pro Gly Pro Ser His Pro Leu Pro Asn Ala Ala 
            20                  25                  30          


Ser Pro Gly Ala Glu Ala Pro Ser Ser Ser Glu Pro His Gly Ala Arg 
        35                  40                  45              


Gly Ser Ser Ser Ser Gly Gly Lys Lys Cys Tyr Lys Leu Glu Asn Glu 
    50                  55                  60                  


Lys Leu Phe Glu Glu Phe Leu Glu Leu Cys Lys Met Gln Xaa Ala Asp 
65                  70                  75                  80  


His Pro Glu Val Val Pro Phe Leu Tyr Asn Arg Gln Gln Arg Ala His 
                85                  90                  95      


Ser Leu Phe Leu Ala Ser Ala Glu Phe Cys Asn Ile Leu Ser Arg Val 
            100                 105                 110         


Leu Ser Arg Ala Arg Ser Arg Pro Ala Lys Leu Tyr Val Tyr Ile Asn 
        115                 120                 125             


Glu Leu 
    130 


<210> 7601
<211> 178
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<400> 7601
Met Ala Xaa Ala Asn Ser Ile Ile Val Leu Asp Asp Asp Asp Glu Asp 
1               5                   10                  15      


Glu Ala Ala Ala Gln Pro Gly Pro Ser His Pro Leu Pro Asn Ala Ala 
            20                  25                  30          


Ser Pro Gly Ala Glu Ala Pro Ser Ser Ser Glu Pro His Gly Ala Arg 
        35                  40                  45              


Gly Ser Ser Ser Ser Gly Gly Lys Lys Cys Tyr Lys Leu Glu Asn Glu 
    50                  55                  60                  


Lys Leu Phe Glu Glu Phe Leu Glu Leu Cys Lys Met Gln Xaa Ala Asp 
65                  70                  75                  80  


His Pro Glu Val Val Pro Phe Leu Tyr Asn Arg Gln Gln Arg Ala His 
                85                  90                  95      


Ser Leu Phe Leu Ala Ser Ala Glu Phe Cys Asn Ile Leu Ser Arg Val 
            100                 105                 110         


Leu Ser Arg Ala Arg Ser Arg Pro Ala Lys Leu Tyr Val Tyr Ile Asn 
        115                 120                 125             


Glu Leu Cys Xaa Val Leu Lys Ala His Ser Ala Lys Lys Lys Leu Asn 
    130                 135                 140                 


Leu Ala Pro Ala Ala Xaa Xaa Ser Asn Glu Pro Ser Gly Asn Asn Pro 
145                 150                 155                 160 


Pro Xaa His Leu Ser Leu Asp Pro Xaa Asn Ala Glu Asn Xaa Ala Ser 
                165                 170                 175     


Gln Ser 
        


<210> 7602
<211> 688
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Selenocysteine

<400> 7602
Met Ala Xaa Ala Asn Ser Ile Ile Val Leu Asp Asp Asp Asp Glu Asp 
1               5                   10                  15      


Glu Ala Ala Ala Gln Pro Gly Pro Ser His Pro Leu Pro Asn Ala Ala 
            20                  25                  30          


Ser Pro Gly Ala Glu Ala Pro Ser Ser Ser Glu Pro His Gly Ala Arg 
        35                  40                  45              


Gly Ser Ser Ser Ser Gly Gly Lys Lys Cys Tyr Lys Leu Glu Asn Glu 
    50                  55                  60                  


Lys Leu Phe Glu Glu Phe Leu Glu Leu Cys Lys Met Gln Xaa Ala Asp 
65                  70                  75                  80  


His Pro Glu Val Val Pro Phe Leu Tyr Asn Arg Gln Gln Arg Ala His 
                85                  90                  95      


Ser Leu Phe Leu Ala Ser Ala Glu Phe Cys Asn Ile Leu Ser Arg Val 
            100                 105                 110         


Leu Ser Arg Ala Arg Ser Arg Pro Ala Lys Leu Tyr Val Tyr Ile Asn 
        115                 120                 125             


Glu Leu Cys Xaa Val Leu Lys Ala His Ser Ala Lys Lys Lys Leu Asn 
    130                 135                 140                 


Leu Ala Pro Ala Ala Xaa Xaa Ser Asn Glu Pro Ser Gly Asn Asn Pro 
145                 150                 155                 160 


Pro Xaa His Leu Ser Leu Asp Pro Xaa Asn Ala Glu Asn Xaa Ala Ser 
                165                 170                 175     


Gln Ser Pro Arg Xaa Arg Gly Ser Arg Arg Gln Ile Gln Arg Leu Glu 
            180                 185                 190         


Gln Leu Leu Ala Leu Tyr Val Ala Glu Ile Arg Arg Leu Gln Glu Lys 
        195                 200                 205             


Glu Leu Asp Leu Ser Glu Leu Asp Asp Pro Asp Ser Ala Tyr Leu Gln 
    210                 215                 220                 


Glu Ala Arg Leu Lys Arg Lys Leu Ile Arg Leu Phe Gly Arg Leu Cys 
225                 230                 235                 240 


Glu Leu Lys Asp Cys Ser Ser Leu Xaa Gly Arg Val Ile Glu Gln Arg 
                245                 250                 255     


Ile Pro Tyr Arg Gly Xaa Arg Tyr Pro Glu Val Asn Arg Arg Ile Glu 
            260                 265                 270         


Arg Leu Ile Asn Lys Pro Gly Pro Asp Xaa Phe Pro Asp Tyr Gly Asp 
        275                 280                 285             


Val Leu Arg Ala Val Glu Lys Ala Ala Ala Arg His Ser Leu Gly Leu 
    290                 295                 300                 


Pro Arg Gln Gln Leu Gln Leu Met Ala Gln Asp Ala Phe Arg Asp Val 
305                 310                 315                 320 


Gly Ile Arg Leu Gln Glu Arg Arg His Leu Asp Leu Ile Tyr Asn Phe 
                325                 330                 335     


Gly Cys His Leu Xaa Asp Asp Tyr Arg Pro Gly Val Asp Pro Ala Leu 
            340                 345                 350         


Ser Asp Pro Val Leu Ala Arg Arg Leu Arg Glu Asn Arg Ser Leu Ala 
        355                 360                 365             


Met Ser Arg Leu Asp Glu Val Ile Ser Lys Tyr Ala Met Leu Gln Asp 
    370                 375                 380                 


Lys Ser Glu Glu Gly Glu Arg Lys Lys Arg Arg Ala Arg Leu Gln Gly 
385                 390                 395                 400 


Xaa Ser Ser His Ser Ala Asp Xaa Pro Glu Ala Ser Leu Asp Ser Gly 
                405                 410                 415     


Glu Gly Pro Ser Gly Met Ala Ser Gln Gly Cys Pro Ser Ala Ser Arg 
            420                 425                 430         


Ala Glu Xaa Asp Asp Glu Asp Asp Glu Glu Ser Asp Glu Glu Glu Glu 
        435                 440                 445             


Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Xaa Asp Ser Glu Glu Glu 
    450                 455                 460                 


Glu Asp Leu Glu Gln Met Gln Glu Gly Gln Glu Asp Asp Glu Glu Glu 
465                 470                 475                 480 


Asp Glu Glu Glu Glu Ala Ala Ala Gly Lys Asp Gly Asp Lys Ser Pro 
                485                 490                 495     


Met Ser Ser Leu Gln Ile Ser Asn Glu Lys Asn Leu Glu Pro Gly Lys 
            500                 505                 510         


Gln Ile Ser Arg Ser Ser Gly Glu Gln Gln Asn Lys Gly Arg Ile Val 
        515                 520                 525             


Ser Pro Ser Leu Leu Ser Glu Glu Pro Leu Ala Pro Ser Ser Ile Asp 
    530                 535                 540                 


Ala Glu Ser Asn Gly Glu Gln Pro Glu Glu Leu Xaa Leu Glu Glu Glu 
545                 550                 555                 560 


Ser Pro Val Ser Gln Leu Phe Glu Leu Glu Ile Glu Ala Leu Pro Leu 
                565                 570                 575     


Asp Xaa Pro Ser Ser Val Glu Xaa Asp Ile Ser Ser Ser Arg Lys Gln 
            580                 585                 590         


Ser Glu Glu Pro Phe Xaa Xaa Val Leu Glu Asn Gly Ala Gly Met Val 
        595                 600                 605             


Ser Ser Xaa Ser Phe Asn Gly Gly Val Ser Pro His Asn Trp Gly Asp 
    610                 615                 620                 


Ser Gly Pro Pro Cys Lys Lys Ser Arg Lys Glu Lys Lys Gln Xaa Gly 
625                 630                 635                 640 


Ser Gly Pro Leu Gly Asn Ser Tyr Val Glu Arg Gln Ser Pro Ala Val 
                645                 650                 655     


Pro Asn Pro Pro Phe Xaa Ala Ser Ser Ala Trp Tyr Leu Gln Asp Lys 
            660                 665                 670         


Cys Gly His Xaa Met Arg Ser Arg Arg Asp His Arg Ala Leu Arg Leu 
        675                 680                 685             


<210> 7603
<211> 740
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (132)..(132)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (162)..(162)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (181)..(181)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (262)..(262)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (282)..(282)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (435)..(435)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(599)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (639)..(639)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (684)..(684)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (695)..(695)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (719)..(719)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (722)..(722)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (726)..(726)
<223> Selenocysteine

<400> 7603
Met Ala Xaa Ala Asn Ser Ile Ile Val Leu Asp Asp Asp Asp Glu Asp 
1               5                   10                  15      


Glu Ala Ala Ala Gln Pro Gly Pro Ser His Pro Leu Pro Asn Ala Ala 
            20                  25                  30          


Ser Pro Gly Ala Glu Ala Pro Ser Ser Ser Glu Pro His Gly Ala Arg 
        35                  40                  45              


Gly Ser Ser Ser Ser Gly Gly Lys Lys Cys Tyr Lys Leu Glu Asn Glu 
    50                  55                  60                  


Lys Leu Phe Glu Glu Phe Leu Glu Leu Cys Lys Met Gln Xaa Ala Asp 
65                  70                  75                  80  


His Pro Glu Val Val Pro Phe Leu Tyr Asn Arg Gln Gln Arg Ala His 
                85                  90                  95      


Ser Leu Phe Leu Ala Ser Ala Glu Phe Cys Asn Ile Leu Ser Arg Val 
            100                 105                 110         


Leu Ser Arg Ala Arg Ser Arg Pro Ala Lys Leu Tyr Val Tyr Ile Asn 
        115                 120                 125             


Glu Leu Cys Xaa Val Leu Lys Ala His Ser Ala Lys Lys Lys Leu Asn 
    130                 135                 140                 


Leu Ala Pro Ala Ala Xaa Xaa Ser Asn Glu Pro Ser Gly Asn Asn Pro 
145                 150                 155                 160 


Pro Xaa His Leu Ser Leu Asp Pro Xaa Asn Ala Glu Asn Xaa Ala Ser 
                165                 170                 175     


Gln Ser Pro Arg Xaa Arg Gly Ser Arg Arg Gln Ile Gln Arg Leu Glu 
            180                 185                 190         


Gln Leu Leu Ala Leu Tyr Val Ala Glu Ile Arg Arg Leu Gln Glu Lys 
        195                 200                 205             


Glu Leu Asp Leu Ser Glu Leu Asp Asp Pro Asp Ser Ala Tyr Leu Gln 
    210                 215                 220                 


Glu Ala Arg Leu Lys Arg Lys Leu Ile Arg Leu Phe Gly Arg Leu Cys 
225                 230                 235                 240 


Glu Leu Lys Asp Cys Ser Ser Leu Xaa Gly Arg Val Ile Glu Gln Arg 
                245                 250                 255     


Ile Pro Tyr Arg Gly Xaa Arg Tyr Pro Glu Val Asn Arg Arg Ile Glu 
            260                 265                 270         


Arg Leu Ile Asn Lys Pro Gly Pro Asp Xaa Phe Pro Asp Tyr Gly Asp 
        275                 280                 285             


Val Leu Arg Ala Val Glu Lys Ala Ala Ala Arg His Ser Leu Gly Leu 
    290                 295                 300                 


Pro Arg Gln Gln Leu Gln Leu Met Ala Gln Asp Ala Phe Arg Asp Val 
305                 310                 315                 320 


Gly Ile Arg Leu Gln Glu Arg Arg His Leu Asp Leu Ile Tyr Asn Phe 
                325                 330                 335     


Gly Cys His Leu Xaa Asp Asp Tyr Arg Pro Gly Val Asp Pro Ala Leu 
            340                 345                 350         


Ser Asp Pro Val Leu Ala Arg Arg Leu Arg Glu Asn Arg Ser Leu Ala 
        355                 360                 365             


Met Ser Arg Leu Asp Glu Val Ile Ser Lys Tyr Ala Met Leu Gln Asp 
    370                 375                 380                 


Lys Ser Glu Glu Gly Glu Arg Lys Lys Arg Arg Ala Arg Leu Gln Gly 
385                 390                 395                 400 


Xaa Ser Ser His Ser Ala Asp Xaa Pro Glu Ala Ser Leu Asp Ser Gly 
                405                 410                 415     


Glu Gly Pro Ser Gly Met Ala Ser Gln Gly Cys Pro Ser Ala Ser Arg 
            420                 425                 430         


Ala Glu Xaa Asp Asp Glu Asp Asp Glu Glu Ser Asp Glu Glu Glu Glu 
        435                 440                 445             


Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Xaa Asp Ser Glu Glu Glu 
    450                 455                 460                 


Glu Asp Leu Glu Gln Met Gln Glu Gly Gln Glu Asp Asp Glu Glu Glu 
465                 470                 475                 480 


Asp Glu Glu Glu Glu Ala Ala Ala Gly Lys Asp Gly Asp Lys Ser Pro 
                485                 490                 495     


Met Ser Ser Leu Gln Ile Ser Asn Glu Lys Asn Leu Glu Pro Gly Lys 
            500                 505                 510         


Gln Ile Ser Arg Ser Ser Gly Glu Gln Gln Asn Lys Gly Arg Ile Val 
        515                 520                 525             


Ser Pro Ser Leu Leu Ser Glu Glu Pro Leu Ala Pro Ser Ser Ile Asp 
    530                 535                 540                 


Ala Glu Ser Asn Gly Glu Gln Pro Glu Glu Leu Xaa Leu Glu Glu Glu 
545                 550                 555                 560 


Ser Pro Val Ser Gln Leu Phe Glu Leu Glu Ile Glu Ala Leu Pro Leu 
                565                 570                 575     


Asp Xaa Pro Ser Ser Val Glu Xaa Asp Ile Ser Ser Ser Arg Lys Gln 
            580                 585                 590         


Ser Glu Glu Pro Phe Xaa Xaa Val Leu Glu Asn Gly Ala Gly Met Val 
        595                 600                 605             


Ser Ser Xaa Ser Phe Asn Gly Gly Val Ser Pro His Asn Trp Gly Asp 
    610                 615                 620                 


Ser Gly Pro Pro Cys Lys Lys Ser Arg Lys Glu Lys Lys Gln Xaa Gly 
625                 630                 635                 640 


Ser Gly Pro Leu Gly Asn Ser Tyr Val Glu Arg Gln Arg Ser Val His 
                645                 650                 655     


Glu Lys Asn Gly Lys Lys Ile Cys Xaa Leu Pro Ser Pro Pro Ser Pro 
            660                 665                 670         


Leu Ala Ser Leu Ala Pro Val Ala Asp Ser Ser Xaa Arg Val Asp Ser 
        675                 680                 685             


Pro Ser His Gly Leu Val Xaa Ser Ser Leu Cys Ile Pro Ser Pro Ala 
    690                 695                 700                 


Arg Leu Ser Gln Xaa Pro His Ser Gln Pro Pro Arg Pro Gly Xaa Cys 
705                 710                 715                 720 


Lys Xaa Ser Val Ala Xaa Gln Cys Asp Pro Glu Glu Ile Ile Val Leu 
                725                 730                 735     


Ser Asp Ser Asp 
            740 


<210> 7604
<211> 665
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(76)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (326)..(326)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (360)..(360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (384)..(384)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (509)..(509)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (523)..(524)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (536)..(536)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (609)..(609)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (634)..(634)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (644)..(644)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (651)..(651)
<223> Selenocysteine

<400> 7604
Met Gln Xaa Ala Asp His Pro Glu Val Val Pro Phe Leu Tyr Asn Arg 
1               5                   10                  15      


Gln Gln Arg Ala His Ser Leu Phe Leu Ala Ser Ala Glu Phe Cys Asn 
            20                  25                  30          


Ile Leu Ser Arg Val Leu Ser Arg Ala Arg Ser Arg Pro Ala Lys Leu 
        35                  40                  45              


Tyr Val Tyr Ile Asn Glu Leu Cys Xaa Val Leu Lys Ala His Ser Ala 
    50                  55                  60                  


Lys Lys Lys Leu Asn Leu Ala Pro Ala Ala Xaa Xaa Ser Asn Glu Pro 
65                  70                  75                  80  


Ser Gly Asn Asn Pro Pro Xaa His Leu Ser Leu Asp Pro Xaa Asn Ala 
                85                  90                  95      


Glu Asn Xaa Ala Ser Gln Ser Pro Arg Xaa Arg Gly Ser Arg Arg Gln 
            100                 105                 110         


Ile Gln Arg Leu Glu Gln Leu Leu Ala Leu Tyr Val Ala Glu Ile Arg 
        115                 120                 125             


Arg Leu Gln Glu Lys Glu Leu Asp Leu Ser Glu Leu Asp Asp Pro Asp 
    130                 135                 140                 


Ser Ala Tyr Leu Gln Glu Ala Arg Leu Lys Arg Lys Leu Ile Arg Leu 
145                 150                 155                 160 


Phe Gly Arg Leu Cys Glu Leu Lys Asp Cys Ser Ser Leu Xaa Gly Arg 
                165                 170                 175     


Val Ile Glu Gln Arg Ile Pro Tyr Arg Gly Xaa Arg Tyr Pro Glu Val 
            180                 185                 190         


Asn Arg Arg Ile Glu Arg Leu Ile Asn Lys Pro Gly Pro Asp Xaa Phe 
        195                 200                 205             


Pro Asp Tyr Gly Asp Val Leu Arg Ala Val Glu Lys Ala Ala Ala Arg 
    210                 215                 220                 


His Ser Leu Gly Leu Pro Arg Gln Gln Leu Gln Leu Met Ala Gln Asp 
225                 230                 235                 240 


Ala Phe Arg Asp Val Gly Ile Arg Leu Gln Glu Arg Arg His Leu Asp 
                245                 250                 255     


Leu Ile Tyr Asn Phe Gly Cys His Leu Xaa Asp Asp Tyr Arg Pro Gly 
            260                 265                 270         


Val Asp Pro Ala Leu Ser Asp Pro Val Leu Ala Arg Arg Leu Arg Glu 
        275                 280                 285             


Asn Arg Ser Leu Ala Met Ser Arg Leu Asp Glu Val Ile Ser Lys Tyr 
    290                 295                 300                 


Ala Met Leu Gln Asp Lys Ser Glu Glu Gly Glu Arg Lys Lys Arg Arg 
305                 310                 315                 320 


Ala Arg Leu Gln Gly Xaa Ser Ser His Ser Ala Asp Xaa Pro Glu Ala 
                325                 330                 335     


Ser Leu Asp Ser Gly Glu Gly Pro Ser Gly Met Ala Ser Gln Gly Cys 
            340                 345                 350         


Pro Ser Ala Ser Arg Ala Glu Xaa Asp Asp Glu Asp Asp Glu Glu Ser 
        355                 360                 365             


Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Xaa 
    370                 375                 380                 


Asp Ser Glu Glu Glu Glu Asp Leu Glu Gln Met Gln Glu Gly Gln Glu 
385                 390                 395                 400 


Asp Asp Glu Glu Glu Asp Glu Glu Glu Glu Ala Ala Ala Gly Lys Asp 
                405                 410                 415     


Gly Asp Lys Ser Pro Met Ser Ser Leu Gln Ile Ser Asn Glu Lys Asn 
            420                 425                 430         


Leu Glu Pro Gly Lys Gln Ile Ser Arg Ser Ser Gly Glu Gln Gln Asn 
        435                 440                 445             


Lys Gly Arg Ile Val Ser Pro Ser Leu Leu Ser Glu Glu Pro Leu Ala 
    450                 455                 460                 


Pro Ser Ser Ile Asp Ala Glu Ser Asn Gly Glu Gln Pro Glu Glu Leu 
465                 470                 475                 480 


Xaa Leu Glu Glu Glu Ser Pro Val Ser Gln Leu Phe Glu Leu Glu Ile 
                485                 490                 495     


Glu Ala Leu Pro Leu Asp Xaa Pro Ser Ser Val Glu Xaa Asp Ile Ser 
            500                 505                 510         


Ser Ser Arg Lys Gln Ser Glu Glu Pro Phe Xaa Xaa Val Leu Glu Asn 
        515                 520                 525             


Gly Ala Gly Met Val Ser Ser Xaa Ser Phe Asn Gly Gly Val Ser Pro 
    530                 535                 540                 


His Asn Trp Gly Asp Ser Gly Pro Pro Cys Lys Lys Ser Arg Lys Glu 
545                 550                 555                 560 


Lys Lys Gln Xaa Gly Ser Gly Pro Leu Gly Asn Ser Tyr Val Glu Arg 
                565                 570                 575     


Gln Arg Ser Val His Glu Lys Asn Gly Lys Lys Ile Cys Xaa Leu Pro 
            580                 585                 590         


Ser Pro Pro Ser Pro Leu Ala Ser Leu Ala Pro Val Ala Asp Ser Ser 
        595                 600                 605             


Xaa Arg Val Asp Ser Pro Ser His Gly Leu Val Xaa Ser Ser Leu Cys 
    610                 615                 620                 


Ile Pro Ser Pro Ala Arg Leu Ser Gln Xaa Pro His Ser Gln Pro Pro 
625                 630                 635                 640 


Arg Pro Gly Xaa Cys Lys Xaa Ser Val Ala Xaa Gln Cys Asp Pro Glu 
                645                 650                 655     


Glu Ile Ile Val Leu Ser Asp Ser Asp 
            660                 665 


<210> 7605
<211> 617
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (109)..(109)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (153)..(153)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (228)..(229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (395)..(395)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (413)..(413)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (416)..(416)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (477)..(477)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (498)..(498)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (540)..(540)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (598)..(598)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (608)..(608)
<223> Selenocysteine

<400> 7605
Met Pro Ala Leu Ser Arg Trp Ala Ser Leu Pro Gly Pro Ser Met Arg 
1               5                   10                  15      


Glu Ala Ala Phe Met Tyr Ser Xaa Ala Val Ala Ile Phe Leu Val Ile 
            20                  25                  30          


Leu Val Ala Ala Leu Gln Gly Ser Ala Pro Arg Glu Ser Pro Leu Pro 
        35                  40                  45              


Tyr His Ile Pro Leu Asp Pro Glu Gly Ser Leu Glu Leu Ser Trp Asn 
    50                  55                  60                  


Val Ser Tyr Xaa Gln Glu Ala Ile His Phe Gln Leu Leu Val Arg Arg 
65                  70                  75                  80  


Leu Lys Ala Gly Val Leu Phe Gly Met Ser Asp Arg Gly Glu Leu Glu 
                85                  90                  95      


Asn Ala Asp Leu Val Val Leu Trp Xaa Asp Gly Asp Xaa Ala Tyr Phe 
            100                 105                 110         


Ala Asp Ala Trp Ser Asp Gln Lys Gly Gln Ile His Leu Asp Pro Gln 
        115                 120                 125             


Gln Asp Tyr Gln Leu Leu Gln Val Gln Arg Xaa Pro Glu Gly Leu Xaa 
    130                 135                 140                 


Leu Leu Phe Lys Arg Pro Phe Gly Xaa Cys Asp Pro Lys Asp Tyr Leu 
145                 150                 155                 160 


Ile Glu Asp Gly Xaa Val His Leu Val Tyr Gly Ile Leu Glu Glu Pro 
                165                 170                 175     


Phe Arg Ser Leu Glu Ala Ile Asn Gly Ser Gly Leu Gln Met Gly Leu 
            180                 185                 190         


Gln Arg Val Gln Leu Leu Lys Pro Asn Ile Pro Glu Pro Glu Leu Pro 
        195                 200                 205             


Ser Asp Ala Cys Xaa Met Glu Val Gln Ala Pro Asn Ile Gln Ile Pro 
    210                 215                 220                 


Ser Gln Glu Xaa Xaa Tyr Trp Cys Tyr Ile Lys Glu Leu Pro Lys Gly 
225                 230                 235                 240 


Phe Ser Arg His His Ile Ile Lys Tyr Glu Pro Ile Val Xaa Lys Gly 
                245                 250                 255     


Asn Glu Ala Leu Val His His Met Glu Val Phe Gln Cys Ala Pro Glu 
            260                 265                 270         


Met Asp Ser Val Pro His Phe Ser Gly Pro Cys Asp Ser Lys Met Lys 
        275                 280                 285             


Pro Asp Arg Leu Asn Tyr Cys Arg His Val Leu Ala Ala Trp Ala Leu 
    290                 295                 300                 


Gly Ala Lys Ala Phe Tyr Tyr Pro Glu Glu Ala Gly Leu Ala Phe Gly 
305                 310                 315                 320 


Gly Pro Gly Ser Ser Arg Tyr Leu Arg Leu Glu Val His Tyr His Asn 
                325                 330                 335     


Pro Leu Val Ile Glu Gly Arg Asn Asp Ser Ser Gly Ile Arg Leu Tyr 
            340                 345                 350         


Tyr Xaa Ala Lys Leu Arg Arg Phe Asn Ala Gly Ile Met Glu Leu Gly 
        355                 360                 365             


Leu Val Tyr Xaa Pro Val Met Ala Ile Pro Pro Arg Glu Xaa Ala Phe 
    370                 375                 380                 


Ile Leu Xaa Gly Tyr Cys Xaa Asp Lys Cys Xaa Gln Leu Ala Leu Pro 
385                 390                 395                 400 


Pro Ser Gly Ile His Ile Phe Ala Ser Gln Leu His Xaa His Leu Xaa 
                405                 410                 415     


Gly Arg Lys Val Val Xaa Val Leu Val Arg Asp Gly Arg Glu Trp Glu 
            420                 425                 430         


Ile Val Asn Gln Asp Asn His Tyr Ser Pro His Phe Gln Glu Ile Arg 
        435                 440                 445             


Met Leu Lys Lys Val Val Ser Val His Pro Gly Asp Val Leu Ile Xaa 
    450                 455                 460                 


Ser Cys Xaa Tyr Asn Xaa Glu Asp Arg Glu Leu Ala Xaa Val Gly Gly 
465                 470                 475                 480 


Phe Gly Ile Leu Glu Glu Met Cys Val Asn Tyr Val His Tyr Tyr Pro 
                485                 490                 495     


Gln Xaa Gln Leu Glu Leu Cys Lys Ser Ala Val Asp Ala Gly Phe Leu 
            500                 505                 510         


Gln Lys Tyr Phe His Leu Ile Asn Arg Phe Asn Asn Glu Asp Val Cys 
        515                 520                 525             


Xaa Cys Pro Gln Ala Ser Val Ser Gln Gln Phe Xaa Ser Val Pro Trp 
    530                 535                 540                 


Asn Ser Phe Asn Arg Asp Val Leu Lys Ala Leu Tyr Ser Phe Ala Pro 
545                 550                 555                 560 


Ile Ser Met His Cys Asn Lys Ser Ser Ala Val Arg Phe Gln Gly Glu 
                565                 570                 575     


Trp Asn Leu Gln Pro Leu Pro Lys Val Ile Ser Xaa Leu Glu Glu Pro 
            580                 585                 590         


Xaa Pro Gln Cys Pro Xaa Ser Gln Gly Arg Ser Pro Ala Gly Pro Xaa 
        595                 600                 605             


Val Val Ser Ile Gly Gly Gly Lys Gly 
    610                 615         


<210> 7606
<211> 244
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(166)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Selenocysteine

<400> 7606
Met Arg Glu Ala Ala Phe Met Tyr Ser Xaa Ala Val Ala Ile Phe Leu 
1               5                   10                  15      


Val Ile Leu Val Ala Ala Leu Gln Gly Ser Ala Pro Arg Glu Ser Pro 
            20                  25                  30          


Leu Pro Tyr His Ile Pro Leu Asp Pro Glu Gly Ser Leu Glu Leu Ser 
        35                  40                  45              


Trp Asn Val Ser Tyr Xaa Gln Glu Ala Ile His Phe Gln Leu Leu Val 
    50                  55                  60                  


Arg Arg Leu Lys Ala Gly Val Leu Phe Gly Met Ser Asp Arg Gly Glu 
65                  70                  75                  80  


Leu Glu Asn Ala Asp Leu Val Val Leu Trp Xaa Asp Gly Asp Xaa Ala 
                85                  90                  95      


Tyr Phe Ala Asp Gly Xaa Val His Leu Val Tyr Gly Ile Leu Glu Glu 
            100                 105                 110         


Pro Phe Arg Ser Leu Glu Ala Ile Asn Gly Ser Gly Leu Gln Met Gly 
        115                 120                 125             


Leu Gln Arg Val Gln Leu Leu Lys Pro Asn Ile Pro Glu Pro Glu Leu 
    130                 135                 140                 


Pro Ser Asp Ala Cys Xaa Met Glu Val Gln Ala Pro Asn Ile Gln Ile 
145                 150                 155                 160 


Pro Ser Gln Glu Xaa Xaa Tyr Trp Cys Tyr Ile Lys Glu Leu Pro Lys 
                165                 170                 175     


Gly Phe Ser Arg His His Ile Ile Lys Tyr Glu Pro Ile Val Xaa Lys 
            180                 185                 190         


Gly Asn Glu Ala Leu Val His His Met Glu Val Phe Gln Cys Ala Pro 
        195                 200                 205             


Glu Met Asp Ser Val Pro His Phe Ser Gly Pro Cys Asp Ser Lys Met 
    210                 215                 220                 


Lys Pro Asp Arg Leu Asn Tyr Cys Arg His Val Leu Ala Ala Trp Ala 
225                 230                 235                 240 


Leu Gly Ala Lys 
                


<210> 7607
<211> 27
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<400> 7607
Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Xaa Glu Lys Ser Pro Xaa Asp 
            20                  25          


<210> 7608
<211> 50
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<400> 7608
Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Xaa Glu Lys Ser Pro Xaa Asp Trp Ala Leu Phe Xaa 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Cys Cys Ser Cys Cys Arg Gly 
        35                  40                  45              


Pro Met 
    50  


<210> 7609
<211> 87
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Selenocysteine

<400> 7609
Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Xaa Glu Lys Ser Pro Xaa Asp Trp Ala Leu Phe Xaa 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Xaa Gly Asp Arg 
        35                  40                  45              


Arg Gly Arg Glu Arg Cys Ala Glu Gly Ser Leu Cys Gln Pro Arg Gln 
    50                  55                  60                  


His His Gly Gln Leu Pro Glu Gly Gly Pro Cys Asp His Gln Arg Xaa 
65                  70                  75                  80  


Gly Arg Gly Gly Cys Gly Ala 
                85          


<210> 7610
<211> 406
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (246)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (297)..(297)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (318)..(318)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (375)..(375)
<223> Selenocysteine

<400> 7610
Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Xaa Glu Lys Ser Pro Xaa Asp Trp Ala Leu Phe Xaa 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Xaa Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Gly Ala His Val Xaa Ile Asn Ala Arg Ala Glu Glu 
                85                  90                  95      


Asp Val Glu Pro Glu Cys Ile Met Glu Lys Val Ala Lys Ala Ser Gly 
            100                 105                 110         


Ala Asn Tyr Ser Phe His Lys Glu Ser Gly Arg Phe Gln Asp Val Gly 
        115                 120                 125             


Pro Gln Ala Pro Val Gly Ser Val Tyr Gln Lys Xaa Asn Ala Val Ser 
    130                 135                 140                 


Glu Ile Lys Arg Val Gly Lys Asp Ser Phe Trp Ala Lys Ala Glu Lys 
145                 150                 155                 160 


Glu Glu Glu Asn Arg Arg Leu Glu Glu Lys Arg Arg Ala Glu Glu Ala 
                165                 170                 175     


Gln Arg Gln Leu Glu Gln Glu Arg Arg Glu Arg Glu Leu Arg Glu Ala 
            180                 185                 190         


Ala Arg Arg Glu Gln Arg Tyr Gln Glu Gln Gly Gly Glu Ala Ser Pro 
        195                 200                 205             


Gln Ser Arg Xaa Trp Glu Gln Gln Gln Glu Val Val Ser Arg Asn Arg 
    210                 215                 220                 


Asn Glu Gln Glu Ser Ala Val His Pro Arg Glu Ile Phe Lys Gln Lys 
225                 230                 235                 240 


Glu Arg Ala Met Ser Xaa Xaa Ser Ile Ser Ser Pro Gln Pro Gly Lys 
                245                 250                 255     


Leu Arg Ser Pro Phe Leu Gln Lys Gln Leu Xaa Gln Pro Glu Xaa His 
            260                 265                 270         


Phe Gly Arg Glu Pro Ala Ala Ala Ile Ser Arg Pro Arg Ala Asp Leu 
        275                 280                 285             


Pro Ala Glu Glu Pro Ala Pro Ser Xaa Pro Pro Cys Leu Val Gln Ala 
    290                 295                 300                 


Glu Glu Glu Ala Val Tyr Glu Glu Pro Pro Glu Gln Glu Xaa Phe Tyr 
305                 310                 315                 320 


Glu Gln Pro Pro Leu Val Gln Gln Gln Gly Ala Gly Ser Glu His Ile 
                325                 330                 335     


Asp His His Ile Gln Gly Gln Gly Leu Ser Gly Gln Gly Leu Cys Ala 
            340                 345                 350         


Arg Ala Leu Tyr Asp Tyr Gln Ala Ala Asp Asp Xaa Glu Ile Ser Phe 
        355                 360                 365             


Asp Pro Glu Asn Leu Ile Xaa Gly Ile Glu Val Ile Asp Glu Gly Trp 
    370                 375                 380                 


Trp Arg Gly Tyr Gly Pro Asp Gly His Phe Gly Met Phe Pro Ala Asn 
385                 390                 395                 400 


Tyr Val Glu Leu Ile Glu 
                405     


<210> 7611
<211> 430
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (236)..(236)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (270)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (295)..(295)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Selenocysteine

<400> 7611
Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Xaa Glu Lys Ser Pro Xaa Asp Trp Ala Leu Phe Xaa 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Xaa Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Xaa Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Xaa Met Ala Ser Phe Leu Lys Gly Ala His 
            100                 105                 110         


Val Xaa Ile Asn Ala Arg Ala Glu Glu Asp Val Glu Pro Glu Cys Ile 
        115                 120                 125             


Met Glu Lys Val Ala Lys Ala Ser Gly Ala Asn Tyr Ser Phe His Lys 
    130                 135                 140                 


Glu Ser Gly Arg Phe Gln Asp Val Gly Pro Gln Ala Pro Val Gly Ser 
145                 150                 155                 160 


Val Tyr Gln Lys Xaa Asn Ala Val Ser Glu Ile Lys Arg Val Gly Lys 
                165                 170                 175     


Asp Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg Leu 
            180                 185                 190         


Glu Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln Glu 
        195                 200                 205             


Arg Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg Tyr 
    210                 215                 220                 


Gln Glu Gln Gly Gly Glu Ala Ser Pro Gln Arg Xaa Trp Glu Gln Gln 
225                 230                 235                 240 


Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Glu Ser Ala Val His 
                245                 250                 255     


Pro Arg Glu Ile Phe Lys Gln Lys Glu Arg Ala Met Ser Xaa Xaa Ser 
            260                 265                 270         


Ile Ser Ser Pro Gln Pro Gly Lys Leu Arg Ser Pro Phe Leu Gln Lys 
        275                 280                 285             


Gln Leu Xaa Gln Pro Glu Xaa His Phe Gly Arg Glu Pro Ala Ala Ala 
    290                 295                 300                 


Ile Ser Arg Pro Arg Ala Asp Leu Pro Ala Glu Glu Pro Ala Pro Ser 
305                 310                 315                 320 


Xaa Pro Pro Cys Leu Val Gln Ala Glu Glu Glu Ala Val Tyr Glu Glu 
                325                 330                 335     


Pro Pro Glu Gln Glu Xaa Phe Tyr Glu Gln Pro Pro Leu Val Gln Gln 
            340                 345                 350         


Gln Gly Ala Gly Ser Glu His Ile Asp His His Ile Gln Gly Gln Gly 
        355                 360                 365             


Leu Ser Gly Gln Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr Gln Ala 
    370                 375                 380                 


Ala Asp Asp Xaa Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile Xaa Gly 
385                 390                 395                 400 


Ile Glu Val Ile Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro Asp Gly 
                405                 410                 415     


His Phe Gly Met Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
            420                 425                 430 


<210> 7612
<211> 431
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (400)..(400)
<223> Selenocysteine

<400> 7612
Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Xaa Glu Lys Ser Pro Xaa Asp Trp Ala Leu Phe Xaa 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Xaa Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Xaa Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Xaa Met Ala Ser Phe Leu Lys Gly Ala His 
            100                 105                 110         


Val Xaa Ile Asn Ala Arg Ala Glu Glu Asp Val Glu Pro Glu Cys Ile 
        115                 120                 125             


Met Glu Lys Val Ala Lys Ala Ser Gly Ala Asn Tyr Ser Phe His Lys 
    130                 135                 140                 


Glu Ser Gly Arg Phe Gln Asp Val Gly Pro Gln Ala Pro Val Gly Ser 
145                 150                 155                 160 


Val Tyr Gln Lys Xaa Asn Ala Val Ser Glu Ile Lys Arg Val Gly Lys 
                165                 170                 175     


Asp Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg Leu 
            180                 185                 190         


Glu Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln Glu 
        195                 200                 205             


Arg Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg Tyr 
    210                 215                 220                 


Gln Glu Gln Gly Gly Glu Ala Ser Pro Gln Ser Arg Xaa Trp Glu Gln 
225                 230                 235                 240 


Gln Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Glu Ser Ala Val 
                245                 250                 255     


His Pro Arg Glu Ile Phe Lys Gln Lys Glu Arg Ala Met Ser Xaa Xaa 
            260                 265                 270         


Ser Ile Ser Ser Pro Gln Pro Gly Lys Leu Arg Ser Pro Phe Leu Gln 
        275                 280                 285             


Lys Gln Leu Xaa Gln Pro Glu Xaa His Phe Gly Arg Glu Pro Ala Ala 
    290                 295                 300                 


Ala Ile Ser Arg Pro Arg Ala Asp Leu Pro Ala Glu Glu Pro Ala Pro 
305                 310                 315                 320 


Ser Xaa Pro Pro Cys Leu Val Gln Ala Glu Glu Glu Ala Val Tyr Glu 
                325                 330                 335     


Glu Pro Pro Glu Gln Glu Xaa Phe Tyr Glu Gln Pro Pro Leu Val Gln 
            340                 345                 350         


Gln Gln Gly Ala Gly Ser Glu His Ile Asp His His Ile Gln Gly Gln 
        355                 360                 365             


Gly Leu Ser Gly Gln Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr Gln 
    370                 375                 380                 


Ala Ala Asp Asp Xaa Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile Xaa 
385                 390                 395                 400 


Gly Ile Glu Val Ile Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro Asp 
                405                 410                 415     


Gly His Phe Gly Met Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
            420                 425                 430     


<210> 7613
<211> 439
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (114)..(114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (279)..(280)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (397)..(397)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Selenocysteine

<400> 7613
Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Xaa Glu Lys Ser Pro Xaa Asp Trp Ala Leu Phe Xaa 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Xaa Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Xaa Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Xaa Met Ala Ser Phe Leu Lys Gly Ala His 
            100                 105                 110         


Val Xaa Ile Asn Ala Arg Ala Glu Glu Asp Val Glu Pro Glu Cys Ile 
        115                 120                 125             


Met Glu Lys Val Ala Lys Ala Ser Gly Ala Asn Tyr Ser Phe His Lys 
    130                 135                 140                 


Glu Ser Gly Arg Phe Gln Asp Val Gly Pro Gln Ala Pro Val Gly Ser 
145                 150                 155                 160 


Val Tyr Gln Lys Xaa Asn Ala Val Ser Glu Ile Lys Arg Val Gly Lys 
                165                 170                 175     


Asp Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg Leu 
            180                 185                 190         


Glu Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln Glu 
        195                 200                 205             


Arg Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg Tyr 
    210                 215                 220                 


Gln Glu Gln Gly Gly Glu Ala Ser Pro Gln Ser Arg Xaa Trp Glu Gln 
225                 230                 235                 240 


Gln Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Gly Ser Xaa Cys 
                245                 250                 255     


Ala Ser Leu Gln Glu Ser Ala Val His Pro Arg Glu Ile Phe Lys Gln 
            260                 265                 270         


Lys Glu Arg Ala Met Ser Xaa Xaa Ser Ile Ser Ser Pro Gln Pro Gly 
        275                 280                 285             


Lys Leu Arg Ser Pro Phe Leu Gln Lys Gln Leu Xaa Gln Pro Glu Xaa 
    290                 295                 300                 


His Phe Gly Arg Glu Pro Ala Ala Ala Ile Ser Arg Pro Arg Ala Asp 
305                 310                 315                 320 


Leu Pro Ala Glu Glu Pro Ala Pro Ser Xaa Pro Pro Cys Leu Val Gln 
                325                 330                 335     


Ala Glu Glu Glu Ala Val Tyr Glu Glu Pro Pro Glu Gln Glu Xaa Phe 
            340                 345                 350         


Tyr Glu Gln Pro Pro Leu Val Gln Gln Gln Gly Ala Gly Ser Glu His 
        355                 360                 365             


Ile Asp His His Ile Gln Gly Gln Gly Leu Ser Gly Gln Gly Leu Cys 
    370                 375                 380                 


Ala Arg Ala Leu Tyr Asp Tyr Gln Ala Ala Asp Asp Xaa Glu Ile Ser 
385                 390                 395                 400 


Phe Asp Pro Glu Asn Leu Ile Xaa Gly Ile Glu Val Ile Asp Glu Gly 
                405                 410                 415     


Trp Trp Arg Gly Tyr Gly Pro Asp Gly His Phe Gly Met Phe Pro Ala 
            420                 425                 430         


Asn Tyr Val Glu Leu Ile Glu 
        435                 


<210> 7614
<211> 382
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(223)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (247)..(247)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (340)..(340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Selenocysteine

<400> 7614
Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Xaa Glu Lys Ser Pro Xaa Asp Trp Ala Leu Phe Xaa 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Xaa Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Xaa Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Xaa Met Ala Ser Phe Leu Lys Gly Ser Val 
            100                 105                 110         


Tyr Gln Lys Xaa Asn Ala Val Ser Glu Ile Lys Arg Val Gly Lys Asp 
        115                 120                 125             


Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg Leu Glu 
    130                 135                 140                 


Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln Glu Arg 
145                 150                 155                 160 


Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg Tyr Gln 
                165                 170                 175     


Glu Gln Gly Gly Glu Ala Ser Pro Gln Ser Arg Xaa Trp Glu Gln Gln 
            180                 185                 190         


Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Glu Ser Ala Val His 
        195                 200                 205             


Pro Arg Glu Ile Phe Lys Gln Lys Glu Arg Ala Met Ser Xaa Xaa Ser 
    210                 215                 220                 


Ile Ser Ser Pro Gln Pro Gly Lys Leu Arg Ser Pro Phe Leu Gln Lys 
225                 230                 235                 240 


Gln Leu Xaa Gln Pro Glu Xaa His Phe Gly Arg Glu Pro Ala Ala Ala 
                245                 250                 255     


Ile Ser Arg Pro Arg Ala Asp Leu Pro Ala Glu Glu Pro Ala Pro Ser 
            260                 265                 270         


Xaa Pro Pro Cys Leu Val Gln Ala Glu Glu Glu Ala Val Tyr Glu Glu 
        275                 280                 285             


Pro Pro Glu Gln Glu Xaa Phe Tyr Glu Gln Pro Pro Leu Val Gln Gln 
    290                 295                 300                 


Gln Gly Ala Gly Ser Glu His Ile Asp His His Ile Gln Gly Gln Gly 
305                 310                 315                 320 


Leu Ser Gly Gln Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr Gln Ala 
                325                 330                 335     


Ala Asp Asp Xaa Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile Xaa Gly 
            340                 345                 350         


Ile Glu Val Ile Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro Asp Gly 
        355                 360                 365             


His Phe Gly Met Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
    370                 375                 380         


<210> 7615
<211> 128
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Selenocysteine

<400> 7615
Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Xaa Glu Lys Ser Pro Xaa Asp Trp Ala Leu Phe Xaa 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Xaa Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Xaa Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Xaa Met Ala Ser Phe Leu Lys Val Arg Pro 
            100                 105                 110         


Gly Gly Pro Cys Asp His Gln Arg Xaa Gly Arg Gly Gly Cys Gly Ala 
        115                 120                 125             


<210> 7616
<211> 62
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (55)..(55)
<223> Selenocysteine

<400> 7616
Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Xaa Glu Lys Ser Pro Xaa Asp Trp Ala Leu Phe Xaa 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Xaa Gly Gly Gly 
        35                  40                  45              


Pro Cys Asp His Gln Arg Xaa Gly Arg Gly Gly Cys Gly Ala 
    50                  55                  60          


<210> 7617
<211> 31
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<400> 7617
Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Xaa Glu Lys Ser Pro Xaa Asp Trp Gly Pro Met 
            20                  25                  30      


<210> 7618
<211> 40
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<400> 7618
Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Xaa Glu Lys Ser Pro Xaa Asp Trp Trp Ala Ala Arg 
            20                  25                  30          


Arg Ala Arg Gly Ser Leu Tyr Leu 
        35                  40  


<210> 7619
<211> 48
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Selenocysteine

<400> 7619
Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Xaa Glu Lys Ser Pro Xaa Asp Trp Trp Ala Ala Arg 
            20                  25                  30          


Arg Ala Arg Val Gly Pro Gly Ala Ala Ser Gly Gly Ser Leu Tyr Leu 
        35                  40                  45              


<210> 7620
<211> 327
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(168)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (239)..(239)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (296)..(296)
<223> Selenocysteine

<400> 7620
Met Ala Ser Phe Leu Lys Gly Ala His Val Xaa Ile Asn Ala Arg Ala 
1               5                   10                  15      


Glu Glu Asp Val Glu Pro Glu Cys Ile Met Glu Lys Val Ala Lys Ala 
            20                  25                  30          


Ser Gly Ala Asn Tyr Ser Phe His Lys Glu Ser Gly Arg Phe Gln Asp 
        35                  40                  45              


Val Gly Pro Gln Ala Pro Val Gly Ser Val Tyr Gln Lys Xaa Asn Ala 
    50                  55                  60                  


Val Ser Glu Ile Lys Arg Val Gly Lys Asp Ser Phe Trp Ala Lys Ala 
65                  70                  75                  80  


Glu Lys Glu Glu Glu Asn Arg Arg Leu Glu Glu Lys Arg Arg Ala Glu 
                85                  90                  95      


Glu Ala Gln Arg Gln Leu Glu Gln Glu Arg Arg Glu Arg Glu Leu Arg 
            100                 105                 110         


Glu Ala Ala Arg Arg Glu Gln Arg Tyr Gln Glu Gln Gly Gly Glu Ala 
        115                 120                 125             


Ser Pro Gln Arg Xaa Trp Glu Gln Gln Gln Glu Val Val Ser Arg Asn 
    130                 135                 140                 


Arg Asn Glu Gln Glu Ser Ala Val His Pro Arg Glu Ile Phe Lys Gln 
145                 150                 155                 160 


Lys Glu Arg Ala Met Ser Xaa Xaa Ser Ile Ser Ser Pro Gln Pro Gly 
                165                 170                 175     


Lys Leu Arg Ser Pro Phe Leu Gln Lys Gln Leu Xaa Gln Pro Glu Xaa 
            180                 185                 190         


His Phe Gly Arg Glu Pro Ala Ala Ala Ile Ser Arg Pro Arg Ala Asp 
        195                 200                 205             


Leu Pro Ala Glu Glu Pro Ala Pro Ser Xaa Pro Pro Cys Leu Val Gln 
    210                 215                 220                 


Ala Glu Glu Glu Ala Val Tyr Glu Glu Pro Pro Glu Gln Glu Xaa Phe 
225                 230                 235                 240 


Tyr Glu Gln Pro Pro Leu Val Gln Gln Gln Gly Ala Gly Ser Glu His 
                245                 250                 255     


Ile Asp His His Ile Gln Gly Gln Gly Leu Ser Gly Gln Gly Leu Cys 
            260                 265                 270         


Ala Arg Ala Leu Tyr Asp Tyr Gln Ala Ala Asp Asp Xaa Glu Ile Ser 
        275                 280                 285             


Phe Asp Pro Glu Asn Leu Ile Xaa Gly Ile Glu Val Ile Asp Glu Gly 
    290                 295                 300                 


Trp Trp Arg Gly Tyr Gly Pro Asp Gly His Phe Gly Met Phe Pro Ala 
305                 310                 315                 320 


Asn Tyr Val Glu Leu Ile Glu 
                325         


<210> 7621
<211> 336
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (201)..(201)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (294)..(294)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Selenocysteine

<400> 7621
Met Lys Ala Xaa Ala Met Xaa Ser Ala Trp Leu Ala Gln Gly Gly Ala 
1               5                   10                  15      


His Val Xaa Ile Asn Ala Arg Ala Glu Glu Asp Val Glu Pro Glu Cys 
            20                  25                  30          


Ile Met Glu Lys Val Ala Lys Ala Ser Gly Ala Asn Tyr Ser Phe His 
        35                  40                  45              


Lys Glu Ser Gly Arg Phe Gln Asp Val Gly Pro Gln Ala Pro Val Gly 
    50                  55                  60                  


Ser Val Tyr Gln Lys Xaa Asn Ala Val Ser Glu Ile Lys Arg Val Gly 
65                  70                  75                  80  


Lys Asp Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg 
                85                  90                  95      


Leu Glu Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln 
            100                 105                 110         


Glu Arg Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg 
        115                 120                 125             


Tyr Gln Glu Gln Gly Gly Glu Ala Ser Pro Gln Ser Arg Xaa Trp Glu 
    130                 135                 140                 


Gln Gln Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Glu Ser Ala 
145                 150                 155                 160 


Val His Pro Arg Glu Ile Phe Lys Gln Lys Glu Arg Ala Met Ser Xaa 
                165                 170                 175     


Xaa Ser Ile Ser Ser Pro Gln Pro Gly Lys Leu Arg Ser Pro Phe Leu 
            180                 185                 190         


Gln Lys Gln Leu Xaa Gln Pro Glu Xaa His Phe Gly Arg Glu Pro Ala 
        195                 200                 205             


Ala Ala Ile Ser Arg Pro Arg Ala Asp Leu Pro Ala Glu Glu Pro Ala 
    210                 215                 220                 


Pro Ser Xaa Pro Pro Cys Leu Val Gln Ala Glu Glu Glu Ala Val Tyr 
225                 230                 235                 240 


Glu Glu Pro Pro Glu Gln Glu Xaa Phe Tyr Glu Gln Pro Pro Leu Val 
                245                 250                 255     


Gln Gln Gln Gly Ala Gly Ser Glu His Ile Asp His His Ile Gln Gly 
            260                 265                 270         


Gln Gly Leu Ser Gly Gln Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr 
        275                 280                 285             


Gln Ala Ala Asp Asp Xaa Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile 
    290                 295                 300                 


Xaa Gly Ile Glu Val Ile Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro 
305                 310                 315                 320 


Asp Gly His Phe Gly Met Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
                325                 330                 335     


<210> 7622
<211> 359
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (165)..(165)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (199)..(200)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Selenocysteine

<400> 7622
Xaa Ala Xaa Ala Met Xaa Ser Ala Trp Leu Ala Gln Gly Xaa Gly Glu 
1               5                   10                  15      


Gly Val Asn Asp Val Arg Lys Gly Ala Cys Ala Ser His Val Ser Xaa 
            20                  25                  30          


Met Ala Ser Phe Leu Lys Gly Ala His Val Xaa Ile Asn Ala Arg Ala 
        35                  40                  45              


Glu Glu Asp Val Glu Pro Glu Cys Ile Met Glu Lys Val Ala Lys Ala 
    50                  55                  60                  


Ser Gly Ala Asn Tyr Ser Phe His Lys Glu Ser Gly Arg Phe Gln Asp 
65                  70                  75                  80  


Val Gly Pro Gln Ala Pro Val Gly Ser Val Tyr Gln Lys Xaa Asn Ala 
                85                  90                  95      


Val Ser Glu Ile Lys Arg Val Gly Lys Asp Ser Phe Trp Ala Lys Ala 
            100                 105                 110         


Glu Lys Glu Glu Glu Asn Arg Arg Leu Glu Glu Lys Arg Arg Ala Glu 
        115                 120                 125             


Glu Ala Gln Arg Gln Leu Glu Gln Glu Arg Arg Glu Arg Glu Leu Arg 
    130                 135                 140                 


Glu Ala Ala Arg Arg Glu Gln Arg Tyr Gln Glu Gln Gly Gly Glu Ala 
145                 150                 155                 160 


Ser Pro Gln Arg Xaa Trp Glu Gln Gln Gln Glu Val Val Ser Arg Asn 
                165                 170                 175     


Arg Asn Glu Gln Glu Ser Ala Val His Pro Arg Glu Ile Phe Lys Gln 
            180                 185                 190         


Lys Glu Arg Ala Met Ser Xaa Xaa Ser Ile Ser Ser Pro Gln Pro Gly 
        195                 200                 205             


Lys Leu Arg Ser Pro Phe Leu Gln Lys Gln Leu Xaa Gln Pro Glu Xaa 
    210                 215                 220                 


His Phe Gly Arg Glu Pro Ala Ala Ala Ile Ser Arg Pro Arg Ala Asp 
225                 230                 235                 240 


Leu Pro Ala Glu Glu Pro Ala Pro Ser Xaa Pro Pro Cys Leu Val Gln 
                245                 250                 255     


Ala Glu Glu Glu Ala Val Tyr Glu Glu Pro Pro Glu Gln Glu Xaa Phe 
            260                 265                 270         


Tyr Glu Gln Pro Pro Leu Val Gln Gln Gln Gly Ala Gly Ser Glu His 
        275                 280                 285             


Ile Asp His His Ile Gln Gly Gln Gly Leu Ser Gly Gln Gly Leu Cys 
    290                 295                 300                 


Ala Arg Ala Leu Tyr Asp Tyr Gln Ala Ala Asp Asp Xaa Glu Ile Ser 
305                 310                 315                 320 


Phe Asp Pro Glu Asn Leu Ile Xaa Gly Ile Glu Val Ile Asp Glu Gly 
                325                 330                 335     


Trp Trp Arg Gly Tyr Gly Pro Asp Gly His Phe Gly Met Phe Pro Ala 
            340                 345                 350         


Asn Tyr Val Glu Leu Ile Glu 
        355                 


<210> 7623
<211> 138
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(11)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Selenocysteine

<400> 7623
Xaa Lys Gln Lys Glu Arg Ala Met Ser Xaa Xaa Ser Ile Ser Ser Pro 
1               5                   10                  15      


Gln Pro Asp Leu Pro Ala Glu Glu Pro Ala Pro Ser Xaa Pro Pro Cys 
            20                  25                  30          


Leu Val Gln Ala Glu Glu Glu Ala Val Tyr Glu Glu Pro Pro Glu Gln 
        35                  40                  45              


Glu Xaa Phe Tyr Glu Gln Pro Pro Leu Val Gln Gln Gln Gly Ala Gly 
    50                  55                  60                  


Ser Glu His Ile Asp His His Ile Gln Gly Gln Gly Leu Ser Gly Gln 
65                  70                  75                  80  


Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr Gln Ala Ala Asp Asp Xaa 
                85                  90                  95      


Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile Xaa Gly Ile Glu Val Ile 
            100                 105                 110         


Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro Asp Gly His Phe Gly Met 
        115                 120                 125             


Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
    130                 135             


<210> 7624
<211> 325
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<400> 7624
Met Ala Arg Pro Val Ser Asp Arg Xaa Pro Ala Pro Leu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ala Gly Xaa Pro Pro Gly Gly Gly Ala Leu Leu Gly Leu Arg 
            20                  25                  30          


Ser Leu Leu Gln Gly Xaa Ser Lys Pro Lys Glu Pro Ala Ser Cys Leu 
        35                  40                  45              


Leu Lys Glu Lys Glu Arg Lys Ala Ala Leu Pro Ala Ala Xaa Xaa Pro 
    50                  55                  60                  


Gly Pro Gly Leu Glu Xaa Ala Gly Pro Ala Asp Ala Pro Ala Gly Ala 
65                  70                  75                  80  


Val Val Gly Gly Gly Ser Pro Arg Gly Arg Pro Gly Pro Val Pro Ala 
                85                  90                  95      


Pro Gly Leu Leu Ala Pro Leu Leu Trp Glu Arg Xaa Leu Pro Phe Gly 
            100                 105                 110         


Asp Val Glu Tyr Val Asp Leu Asp Ala Phe Leu Leu Glu His Gly Leu 
        115                 120                 125             


Pro Pro Ser Pro Pro Pro Pro Gly Gly Pro Ser Pro Glu Pro Ser Pro 
    130                 135                 140                 


Ala Arg Xaa Pro Ala Pro Ser Pro Gly Pro Gly Ser Cys Gly Ser Ala 
145                 150                 155                 160 


Ser Pro Arg Ser Ser Pro Gly His Ala Pro Ala Arg Ala Ala Leu Gly 
                165                 170                 175     


Xaa Ala Ser Gly His Arg Ala Gly Leu Xaa Ser Arg Asp Xaa Pro Ser 
            180                 185                 190         


Pro Val Asp Pro Asp Xaa Val Glu Val Leu Met Xaa Phe Glu Pro Asp 
        195                 200                 205             


Pro Ala Asp Leu Ala Leu Ser Ser Ile Pro Gly His Glu Xaa Phe Asp 
    210                 215                 220                 


Pro Arg Arg His Arg Phe Ser Glu Glu Glu Leu Lys Pro Gln Pro Ile 
225                 230                 235                 240 


Met Lys Lys Ala Arg Lys Ile Gln Val Pro Glu Glu Gln Lys Asp Glu 
                245                 250                 255     


Lys Tyr Trp Ser Arg Arg Tyr Lys Asn Asn Glu Ala Ala Lys Arg Ser 
            260                 265                 270         


Arg Asp Ala Arg Arg Leu Lys Glu Asn Gln Ile Ser Val Arg Ala Ala 
        275                 280                 285             


Phe Leu Glu Lys Glu Asn Ala Leu Leu Arg Gln Glu Val Val Ala Val 
    290                 295                 300                 


Arg Gln Glu Leu Ser His Tyr Arg Ala Val Leu Ser Arg Tyr Gln Ala 
305                 310                 315                 320 


Gln His Gly Ala Leu 
                325 


<210> 7625
<211> 262
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (62)..(63)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (190)..(190)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Selenocysteine

<400> 7625
Met Ala Arg Pro Val Ser Asp Arg Xaa Pro Ala Pro Leu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ala Gly Xaa Pro Pro Gly Gly Gly Ala Leu Leu Gly Leu Arg 
            20                  25                  30          


Ser Leu Leu Gln Gly Xaa Ser Lys Pro Lys Glu Pro Ala Ser Cys Leu 
        35                  40                  45              


Leu Lys Glu Lys Glu Arg Lys Ala Ala Leu Pro Ala Ala Xaa Xaa Pro 
    50                  55                  60                  


Gly Pro Gly Leu Glu Xaa Ala Gly Pro Ala Asp Ala Pro Ala Gly Ala 
65                  70                  75                  80  


Val Val Gly Gly Gly Ser Pro Arg Gly Arg Pro Gly Pro Val Pro Ala 
                85                  90                  95      


Pro Gly Leu Leu Ala Pro Leu Leu Trp Glu Arg Xaa Leu Pro Phe Gly 
            100                 105                 110         


Asp Val Glu Tyr Val Asp Leu Asp Ala Phe Leu Leu Glu His Gly Leu 
        115                 120                 125             


Pro Pro Ser Pro Pro Pro Pro Gly Gly Pro Ser Pro Glu Pro Ser Pro 
    130                 135                 140                 


Ala Arg Xaa Pro Ala Pro Ser Pro Gly Pro Gly Ser Cys Gly Ser Ala 
145                 150                 155                 160 


Ser Pro Arg Ser Ser Pro Gly His Ala Pro Ala Arg Ala Ala Leu Gly 
                165                 170                 175     


Xaa Ala Ser Gly His Arg Ala Gly Leu Xaa Ser Arg Asp Xaa Pro Ser 
            180                 185                 190         


Pro Val Asp Pro Asp Xaa Val Glu Val Leu Met Xaa Phe Glu Pro Asp 
        195                 200                 205             


Pro Ala Asp Leu Ala Leu Ser Ser Ile Pro Gly His Glu Xaa Phe Asp 
    210                 215                 220                 


Pro Arg Arg His Arg Phe Ser Glu Glu Glu Leu Lys Pro Gln Pro Ile 
225                 230                 235                 240 


Met Lys Lys Ala Arg Lys Ile Gln Val Pro Glu Glu Gln Lys Val Ser 
                245                 250                 255     


Arg Ala Gly Cys Gly Arg 
            260         


<210> 7626
<211> 123
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<400> 7626
Met Xaa Phe Glu Pro Asp Pro Ala Asp Leu Ala Leu Ser Ser Ile Pro 
1               5                   10                  15      


Gly His Glu Xaa Phe Asp Pro Arg Arg His Arg Phe Ser Glu Glu Glu 
            20                  25                  30          


Leu Lys Pro Gln Pro Ile Met Lys Lys Ala Arg Lys Ile Gln Val Pro 
        35                  40                  45              


Glu Glu Gln Lys Asp Glu Lys Tyr Trp Ser Arg Arg Tyr Lys Asn Asn 
    50                  55                  60                  


Glu Ala Ala Lys Arg Ser Arg Asp Ala Arg Arg Leu Lys Glu Asn Gln 
65                  70                  75                  80  


Ile Ser Val Arg Ala Ala Phe Leu Glu Lys Glu Asn Ala Leu Leu Arg 
                85                  90                  95      


Gln Glu Val Val Ala Val Arg Gln Glu Leu Ser His Tyr Arg Ala Val 
            100                 105                 110         


Leu Ser Arg Tyr Gln Ala Gln His Gly Ala Leu 
        115                 120             


<210> 7627
<211> 343
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (60)..(60)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (105)..(106)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (136)..(136)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (167)..(167)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (341)..(341)
<223> Selenocysteine

<400> 7627
Met Met Phe Pro Gly Leu Leu Ala Pro Pro Ala Gly Tyr Pro Ser Leu 
1               5                   10                  15      


Leu Arg Pro Xaa Pro Xaa Leu Xaa Leu Pro Gln Ser Leu Gln Ser Ala 
            20                  25                  30          


Phe Ser Gly His Ser Ser Phe Leu Val Glu Asp Leu Ile Arg Ile Ser 
        35                  40                  45              


Arg Pro Pro Ala Tyr Leu Pro Arg Ser Val Pro Xaa Ala Ser Met Ser 
    50                  55                  60                  


Pro Pro Arg Gln Gly Ala Pro Xaa Ala Leu Xaa Asp Xaa Gly Ala Ser 
65                  70                  75                  80  


Asp Leu Gly Ser Pro Gly Pro Gly Ser Arg Arg Gly Gly Ser Pro Pro 
                85                  90                  95      


Xaa Ala Phe Ser Pro Ala Ser Glu Xaa Xaa Phe Leu Lys Phe Gly Val 
            100                 105                 110         


Asn Ala Ile Leu Ser Ser Gly Pro Arg Xaa Glu Xaa Ser Pro Ala Leu 
        115                 120                 125             


Leu Gln Ser Val Pro Pro Lys Xaa Phe Ala Phe Pro Tyr Phe Glu Gly 
    130                 135                 140                 


Ser Phe Gln Pro Phe Ile Arg Ser Ser Tyr Phe Pro Ala Ser Ser Ser 
145                 150                 155                 160 


Val Val Pro Ile Pro Gly Xaa Phe Ser Trp Pro Leu Ala Ala Arg Gly 
                165                 170                 175     


Lys Pro Arg Arg Gly Met Leu Arg Arg Ala Val Phe Ser Asp Val Gln 
            180                 185                 190         


Arg Lys Ala Leu Glu Lys Met Phe Gln Lys Gln Lys Tyr Ile Ser Lys 
        195                 200                 205             


Pro Asp Arg Lys Lys Leu Ala Ala Lys Leu Gly Leu Lys Asp Ser Gln 
    210                 215                 220                 


Val Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Arg Asn Ser Lys 
225                 230                 235                 240 


Glu Arg Glu Leu Leu Ser Ser Gly Gly Cys Arg Glu Gln Xaa Leu Pro 
                245                 250                 255     


Xaa Lys Leu Asn Pro His Pro Asp Leu Ser Asp Val Gly Gln Lys Gly 
            260                 265                 270         


Pro Gly Asn Glu Glu Glu Glu Glu Gly Pro Gly Ser Pro Ser His Arg 
        275                 280                 285             


Leu Ala Tyr His Ala Ser Ser Asp Pro Gln His Leu Arg Asp Pro Arg 
    290                 295                 300                 


Leu Pro Gly Pro Leu Pro Pro Ser Pro Ala His Ser Ser Ser Pro Gly 
305                 310                 315                 320 


Lys Pro Ser Asp Phe Ser Asp Ser Glu Glu Glu Glu Glu Gly Glu Glu 
                325                 330                 335     


Gln Glu Glu Ile Xaa Val Ser 
            340             


<210> 7628
<211> 339
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (51)..(51)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (64)..(64)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Selenocysteine

<400> 7628
Met Leu Pro Ser Ala Val Ala Ala His Ala Gly Ala Tyr Trp Asp Val 
1               5                   10                  15      


Val Ala Ser Ser Ala Leu Leu Asn Leu Pro Ala Ala Pro Gly Phe Gly 
            20                  25                  30          


Asn Leu Gly Lys Ser Phe Leu Ile Glu Asn Leu Leu Arg Val Gly Gly 
        35                  40                  45              


Ala Pro Xaa Pro Arg Leu Gln Pro Pro Ala Pro His Asp Pro Ala Xaa 
    50                  55                  60                  


Ala Leu Ala Xaa Ala Gly Ala Gln Leu Arg Pro Leu Pro Ala Ser Pro 
65                  70                  75                  80  


Val Pro Leu Lys Leu Cys Pro Ala Ala Glu Gln Val Ser Pro Ala Gly 
                85                  90                  95      


Ala Pro Tyr Gly Xaa Arg Trp Ala Phe Gln Val Leu Ser Pro Ser Ala 
            100                 105                 110         


Asp Ser Ala Arg Leu Pro Gly Arg Ala Pro Gly Asp Arg Asp Cys Xaa 
        115                 120                 125             


Phe Gln Pro Ser Ala Pro Ala Pro Ser Lys Pro Phe Leu Leu Ser Xaa 
    130                 135                 140                 


Pro Pro Phe Tyr Ser Ala Cys Cys Gly Gly Ser Cys Arg Arg Pro Ala 
145                 150                 155                 160 


Ser Ser Xaa Ala Phe Pro Arg Glu Glu Ser Met Leu Pro Leu Leu Xaa 
                165                 170                 175     


Gln Asp Ser Asn Ser Lys Ala Arg Arg Gly Ile Leu Arg Arg Ala Val 
            180                 185                 190         


Phe Ser Glu Asp Gln Arg Lys Ala Leu Glu Lys Met Phe Gln Lys Gln 
        195                 200                 205             


Lys Tyr Ile Ser Lys Xaa Asp Arg Lys Lys Leu Ala Ile Asn Leu Gly 
    210                 215                 220                 


Leu Lys Glu Ser Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Met Lys 
225                 230                 235                 240 


Trp Arg Asn Ser Lys Glu Lys Glu Val Leu Ser Asn Arg Cys Ile Gln 
                245                 250                 255     


Glu Val Gly Leu Gln Glu Asp Pro Leu Ser Arg Ser Ala Leu Gly Phe 
            260                 265                 270         


Pro Ser Pro Cys Pro Ser Ile Trp Asp Val Pro Gln Gln His Ser Ser 
        275                 280                 285             


Pro Arg Trp Arg Glu Asn Ser Pro Glu Pro Ser Glu Arg Leu Ile Gln 
    290                 295                 300                 


Glu Ser Ser Gly Ala Pro Pro Pro Glu Ala Asn Ser Leu Gln Gly Ala 
305                 310                 315                 320 


Leu Tyr Leu Cys Ser Glu Glu Glu Ala Gly Ser Lys Gly Val Leu Xaa 
                325                 330                 335     


Gly Ala Val 
            


<210> 7629
<211> 1058
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (300)..(300)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (417)..(417)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (430)..(430)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (462)..(462)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (554)..(554)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (560)..(560)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (584)..(584)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (648)..(648)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (663)..(663)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (690)..(690)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (703)..(703)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (746)..(746)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (758)..(758)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (764)..(764)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (828)..(828)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (855)..(855)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (898)..(898)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (933)..(933)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (972)..(972)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (980)..(980)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1040)..(1040)
<223> Selenocysteine

<400> 7629
Met Xaa Xaa Val Val Val His Val Asp Ser Lys Ala Glu Leu Xaa Xaa 
1               5                   10                  15      


Leu Leu Glu Gln Trp Glu Lys Glu His Gly Ser Gly Gln Asp Met Val 
            20                  25                  30          


Pro Ile Leu Xaa Arg Met Ser Gln Leu Ile Glu Lys Glu Xaa Glu Glu 
        35                  40                  45              


Tyr Arg Lys Gly Asp Pro Asp Pro Phe Asp Asp Arg His Pro Gly Arg 
    50                  55                  60                  


Ala Asp Pro Glu Cys Met Leu Gly His Leu Leu Arg Ile Leu Phe Lys 
65                  70                  75                  80  


Asn Asp Asp Phe Met Asn Ala Leu Val Asn Ala Tyr Val Met Xaa Ser 
                85                  90                  95      


Arg Glu Pro Pro Leu Asn Xaa Ala Ala Cys Arg Leu Leu Leu Asp Ile 
            100                 105                 110         


Met Pro Gly Leu Glu Xaa Ala Val Val Phe Gln Glu Lys Glu Gly Ile 
        115                 120                 125             


Val Glu Asn Leu Phe Lys Trp Ala Arg Glu Ala Asp Gln Pro Leu Arg 
    130                 135                 140                 


Xaa Tyr Ser Xaa Gly Leu Leu Gly Gly Ala Met Glu Asn Gln Asp Ile 
145                 150                 155                 160 


Ala Ala Asn Tyr Arg Asp Glu Asn Ser Gln Leu Val Ala Ile Val Leu 
                165                 170                 175     


Arg Arg Leu Arg Glu Leu Gln Leu Gln Glu Val Ala Leu Arg Gln Glu 
            180                 185                 190         


Asn Lys Arg Pro Ser Pro Arg Lys Leu Ser Ser Glu Pro Leu Leu Pro 
        195                 200                 205             


Leu Asp Glu Glu Ala Val Asp Met Asp Tyr Gly Asp Met Ala Val Asp 
    210                 215                 220                 


Asp Ala Glu Ile Gln Lys Ser Ala Leu Gln Ile Ile Ile Asn Cys Val 
225                 230                 235                 240 


Cys Gly Pro Asp Asn Arg Ile Ser Ser Ile Gly Lys Phe Ile Ser Gly 
                245                 250                 255     


Xaa Pro Arg Arg Lys Leu Pro Gln Asn Pro Lys Ser Ser Glu His Xaa 
            260                 265                 270         


Leu Ala Lys Met Trp Asn Val Val Gln Ser Asn Asn Gly Ile Lys Val 
        275                 280                 285             


Leu Leu Ser Leu Leu Ser Ile Lys Met Pro Ile Xaa Asp Ala Asp Gln 
    290                 295                 300                 


Ile Arg Ala Leu Ala Cys Lys Ala Leu Val Gly Leu Ser Arg Ser Ser 
305                 310                 315                 320 


Xaa Val Arg Gln Ile Ile Ser Lys Leu Pro Leu Phe Ser Ser Cys Gln 
                325                 330                 335     


Ile Gln Gln Leu Met Lys Glu Pro Val Leu Gln Asp Lys Arg Ser Asp 
            340                 345                 350         


His Val Lys Phe Cys Lys Tyr Ala Ala Glu Leu Ile Glu Arg Val Ser 
        355                 360                 365             


Gly Lys Pro Leu Leu Ile Gly Xaa Asp Val Ser Leu Ala Arg Leu Gln 
    370                 375                 380                 


Lys Ala Asp Val Val Ala Gln Ser Arg Ile Ser Phe Pro Glu Lys Glu 
385                 390                 395                 400 


Leu Leu Leu Leu Ile Arg Asn His Leu Ile Ser Lys Gly Leu Gly Glu 
                405                 410                 415     


Xaa Ala Xaa Val Leu Xaa Lys Glu Ala Asp Leu Pro Met Xaa Ala Ala 
            420                 425                 430         


Ser His Ser Ser Ala Phe Xaa Pro Val Xaa Ala Ala Ala Ser Pro Val 
        435                 440                 445             


Ser Leu Pro Arg Xaa Pro Arg Ile Ala Asn Gly Ile Ala Xaa Arg Leu 
    450                 455                 460                 


Gly Ser His Ala Ala Val Gly Ala Ser Ala Pro Ser Ala Pro Xaa Ala 
465                 470                 475                 480 


His Pro Gln Pro Arg Pro Pro Gln Gly Pro Leu Ala Leu Pro Gly Pro 
                485                 490                 495     


Ser Tyr Ala Gly Asn Ser Pro Leu Ile Gly Arg Ile Ser Phe Ile Arg 
            500                 505                 510         


Glu Arg Pro Ser Pro Cys Asn Gly Arg Lys Ile Arg Val Leu Arg Gln 
        515                 520                 525             


Lys Ser Asp His Gly Ala Tyr Ser Gln Ser Pro Ala Ile Lys Lys Gln 
    530                 535                 540                 


Leu Asp Arg His Leu Pro Ser Pro Pro Xaa Leu Asp Ser Ile Ile Xaa 
545                 550                 555                 560 


Glu Tyr Leu Arg Glu Gln His Ala Arg Cys Lys Asn Pro Val Ala Xaa 
                565                 570                 575     


Cys Pro Pro Phe Ser Leu Phe Xaa Pro His Gln Cys Pro Glu Pro Lys 
            580                 585                 590         


Gln Arg Arg Gln Ala Pro Ile Asn Phe Xaa Ser Arg Leu Asn Arg Arg 
        595                 600                 605             


Ala Ser Phe Pro Lys Tyr Gly Gly Val Asp Gly Gly Cys Phe Asp Arg 
    610                 615                 620                 


His Leu Ile Phe Ser Arg Phe Arg Pro Ile Ser Val Phe Arg Glu Ala 
625                 630                 635                 640 


Asn Glu Asp Glu Ser Gly Phe Xaa Cys Cys Ala Phe Ser Ala Arg Glu 
                645                 650                 655     


Arg Phe Leu Met Leu Gly Xaa Cys Xaa Gly Gln Leu Lys Leu Tyr Asn 
            660                 665                 670         


Val Phe Ser Gly Gln Glu Glu Ala Ser Tyr Asn Cys His Asn Ser Ala 
        675                 680                 685             


Ile Xaa His Leu Glu Pro Ser Arg Asp Gly Ser Leu Leu Leu Xaa Ser 
    690                 695                 700                 


Ala Xaa Trp Ser Gln Pro Leu Ser Ala Leu Trp Gly Met Lys Ser Val 
705                 710                 715                 720 


Phe Asp Met Lys His Ser Phe Xaa Glu Asp His Tyr Val Glu Phe Ser 
                725                 730                 735     


Lys His Ser Gln Asp Arg Val Ile Gly Xaa Lys Gly Asp Ile Ala His 
            740                 745                 750         


Ile Tyr Asp Ile Gln Xaa Gly Asn Lys Leu Leu Xaa Leu Phe Asn Pro 
        755                 760                 765             


Asp Leu Ala Asn Asn Tyr Lys Arg Asn Cys Ala Xaa Phe Asn Pro Xaa 
    770                 775                 780                 


Asp Asp Leu Val Leu Asn Asp Gly Val Leu Trp Asp Val Arg Ser Ala 
785                 790                 795                 800 


Gln Ala Ile His Lys Phe Asp Lys Phe Asn Met Asn Ile Ser Gly Val 
                805                 810                 815     


Phe His Pro Asn Gly Leu Glu Val Ile Ile Asn Xaa Glu Ile Trp Asp 
            820                 825                 830         


Leu Arg Xaa Phe His Leu Leu His Xaa Val Pro Ala Leu Asp Gln Cys 
        835                 840                 845             


Arg Val Val Phe Asn His Xaa Gly Xaa Val Met Tyr Gly Ala Met Leu 
    850                 855                 860                 


Gln Ala Asp Asp Glu Asp Asp Leu Met Glu Glu Arg Met Lys Ser Pro 
865                 870                 875                 880 


Phe Gly Ser Ser Phe Arg Xaa Phe Asn Ala Xaa Asp Tyr Lys Pro Ile 
                885                 890                 895     


Ala Xaa Ile Asp Val Lys Arg Asn Ile Phe Asp Leu Cys Xaa Asp Xaa 
            900                 905                 910         


Lys Asp Cys Tyr Leu Ala Val Ile Glu Asn Gln Gly Ser Met Asp Ala 
        915                 920                 925             


Leu Asn Met Asp Xaa Val Cys Arg Leu Tyr Glu Val Gly Arg Gln Arg 
    930                 935                 940                 


Leu Ala Glu Asp Glu Asp Glu Glu Glu Asp Gln Glu Glu Glu Glu Gln 
945                 950                 955                 960 


Glu Glu Glu Asp Asp Asp Glu Asp Asp Asp Asp Xaa Asp Asp Leu Asp 
                965                 970                 975     


Glu Leu Asp Xaa Asp Gln Leu Leu Glu Ala Glu Leu Glu Glu Asp Asp 
            980                 985                 990         


Asn Asn Glu Asn Ala Gly Glu Asp  Gly Asp Asn Asp Phe  Ser Pro Ser 
        995                 1000                 1005             


Asp Glu  Glu Leu Ala Asn Leu  Leu Glu Glu Gly Glu  Asp Gly Glu 
    1010                 1015                 1020             


Asp Glu  Asp Ser Asp Ala Asp  Glu Glu Val Glu Leu  Ile Leu Gly 
    1025                 1030                 1035             


Asp Xaa  Asp Ser Ser Asp Asn  Ser Asp Leu Glu Asp  Asp Ile Ile 
    1040                 1045                 1050             


Leu Ser  Leu Asn Glu 
    1055             


<210> 7630
<211> 1507
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (118)..(118)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (148)..(148)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (256)..(257)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (314)..(314)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (335)..(335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (371)..(371)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (461)..(461)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (546)..(546)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (631)..(631)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (653)..(653)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (656)..(656)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (706)..(706)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (825)..(825)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (866)..(866)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (868)..(868)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (871)..(871)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (879)..(879)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (888)..(888)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (891)..(891)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (902)..(902)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1003)..(1003)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1009)..(1009)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1025)..(1025)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1051)..(1051)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1097)..(1097)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1112)..(1112)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1114)..(1114)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1152)..(1152)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1177)..(1177)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1195)..(1195)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1207)..(1207)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1213)..(1213)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1229)..(1229)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1277)..(1277)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1284)..(1284)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1290)..(1290)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1304)..(1304)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1306)..(1306)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1336)..(1336)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1340)..(1340)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1347)..(1347)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1359)..(1359)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1361)..(1361)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1382)..(1382)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1421)..(1421)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1429)..(1429)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1489)..(1489)
<223> Selenocysteine

<400> 7630
Met Xaa Xaa Val Val Val His Val Asp Ser Lys Ala Glu Leu Xaa Xaa 
1               5                   10                  15      


Leu Leu Glu Gln Trp Glu Lys Glu His Gly Ser Gly Gln Asp Met Val 
            20                  25                  30          


Pro Ile Leu Xaa Arg Met Ser Gln Leu Ile Glu Lys Glu Xaa Glu Glu 
        35                  40                  45              


Tyr Arg Lys Gly Asp Pro Asp Pro Phe Asp Asp Arg His Pro Gly Arg 
    50                  55                  60                  


Ala Asp Pro Glu Cys Met Leu Gly His Leu Leu Arg Ile Leu Phe Lys 
65                  70                  75                  80  


Asn Asp Asp Phe Met Asn Ala Leu Val Asn Ala Tyr Val Met Xaa Ser 
                85                  90                  95      


Arg Glu Pro Pro Leu Asn Xaa Ala Ala Cys Arg Leu Leu Leu Asp Ile 
            100                 105                 110         


Met Pro Gly Leu Glu Xaa Ala Val Val Phe Gln Glu Lys Glu Gly Ile 
        115                 120                 125             


Val Glu Asn Leu Phe Lys Trp Ala Arg Glu Ala Asp Gln Pro Leu Arg 
    130                 135                 140                 


Xaa Tyr Ser Xaa Gly Leu Leu Gly Gly Ala Met Glu Asn Gln Asp Ile 
145                 150                 155                 160 


Ala Ala Asn Tyr Arg Asp Glu Asn Ser Gln Leu Val Ala Ile Val Leu 
                165                 170                 175     


Arg Arg Leu Arg Glu Leu Gln Leu Gln Glu Val Ala Leu Arg Gln Glu 
            180                 185                 190         


Asn Lys Arg Pro Ser Pro Arg Lys Leu Ser Ser Glu Pro Leu Leu Pro 
        195                 200                 205             


Leu Asp Glu Glu Ala Val Asp Met Asp Tyr Gly Asp Met Ala Val Asp 
    210                 215                 220                 


Val Val Asp Gly Asp Gln Glu Glu Ala Ser Gly Asp Met Glu Ile Ser 
225                 230                 235                 240 


Phe His Leu Asp Ser Gly His Lys Xaa Ser Ser Arg Val Asn Ser Xaa 
                245                 250                 255     


Xaa Lys Pro Glu Asp Gly Gly Leu Lys Lys Asn Lys Ser Ala Lys Gln 
            260                 265                 270         


Gly Asp Arg Glu Asn Phe Arg Lys Ala Lys Gln Lys Leu Gly Phe Ser 
        275                 280                 285             


Ser Ser Asp Pro Asp Arg Met Phe Val Glu Leu Ser Asn Ser Ser Trp 
    290                 295                 300                 


Ser Glu Met Ser Pro Trp Val Ile Gly Xaa Asn Tyr Xaa Leu Tyr Pro 
305                 310                 315                 320 


Met Xaa Pro Ala Ile Glu Gln Arg Leu Ile Leu Gln Tyr Leu Xaa Pro 
                325                 330                 335     


Leu Gly Glu Tyr Gln Glu Leu Leu Pro Ile Phe Met Gln Leu Gly Ser 
            340                 345                 350         


Arg Glu Leu Met Met Phe Tyr Ile Asp Leu Lys Gln Xaa Asn Asp Val 
        355                 360                 365             


Leu Leu Xaa Phe Glu Ala Leu Lys His Leu Ala Ser Leu Leu Leu His 
    370                 375                 380                 


Asn Lys Phe Ala Xaa Glu Phe Val Ala His Gly Gly Val Gln Lys Leu 
385                 390                 395                 400 


Leu Glu Ile Pro Arg Pro Ser Met Ala Ala Xaa Gly Val Ser Met Cys 
                405                 410                 415     


Leu Tyr Tyr Leu Ser Tyr Asn Gln Asp Ala Met Glu Arg Val Cys Met 
            420                 425                 430         


His Pro His Asn Val Leu Ser Asp Val Val Asn Tyr Xaa Leu Trp Leu 
        435                 440                 445             


Met Glu Cys Ser His Ala Ser Gly Cys Cys His Ala Xaa Met Phe Phe 
    450                 455                 460                 


Ser Ile Cys Phe Ser Phe Arg Ala Val Leu Glu Leu Phe Asp Arg Tyr 
465                 470                 475                 480 


Asp Gly Leu Arg Arg Leu Val Asn Leu Ile Ser Xaa Leu Glu Ile Leu 
                485                 490                 495     


Asn Leu Glu Asp Gln Gly Ala Leu Leu Ser Asp Asp Glu Ile Phe Ala 
            500                 505                 510         


Ser Arg Gln Xaa Gly Lys His Xaa Cys Met Ala Leu Arg Lys Tyr Phe 
        515                 520                 525             


Glu Ala His Leu Ala Ile Lys Leu Glu Gln Val Lys Gln Ser Leu Gln 
    530                 535                 540                 


Arg Xaa Glu Gly Gly Ile Leu Val His Pro Gln Pro Pro Tyr Lys Ala 
545                 550                 555                 560 


Cys Ser Tyr Xaa His Glu Gln Ile Val Glu Met Met Glu Phe Leu Ile 
                565                 570                 575     


Glu Tyr Gly Pro Ala Gln Leu Tyr Trp Glu Pro Ala Glu Val Phe Leu 
            580                 585                 590         


Lys Leu Ser Cys Val Gln Leu Leu Leu Gln Leu Ile Ser Ile Ala Cys 
        595                 600                 605             


Asn Trp Lys Xaa Tyr Tyr Ala Arg Asn Asp Xaa Val Arg Phe Ala Leu 
    610                 615                 620                 


Asp Val Leu Ala Ile Leu Xaa Val Val Pro Lys Ile Gln Leu Gln Leu 
625                 630                 635                 640 


Ala Glu Ser Val Asp Val Leu Asp Glu Ala Gly Ser Xaa Val Ser Xaa 
                645                 650                 655     


Val Gly Ile Ser Ile Ile Leu Gly Val Ala Glu Gly Glu Phe Phe Ile 
            660                 665                 670         


His Asp Ala Glu Ile Gln Lys Ser Ala Leu Gln Ile Ile Ile Asn Cys 
        675                 680                 685             


Val Cys Gly Pro Asp Asn Arg Ile Ser Ser Ile Gly Lys Phe Ile Ser 
    690                 695                 700                 


Gly Xaa Pro Arg Arg Lys Leu Pro Gln Asn Pro Lys Ser Ser Glu His 
705                 710                 715                 720 


Xaa Leu Ala Lys Met Trp Asn Val Val Gln Ser Asn Asn Gly Ile Lys 
                725                 730                 735     


Val Leu Leu Ser Leu Leu Ser Ile Lys Met Pro Ile Xaa Asp Ala Asp 
            740                 745                 750         


Gln Ile Arg Ala Leu Ala Cys Lys Ala Leu Val Gly Leu Ser Arg Ser 
        755                 760                 765             


Ser Xaa Val Arg Gln Ile Ile Ser Lys Leu Pro Leu Phe Ser Ser Cys 
    770                 775                 780                 


Gln Ile Gln Gln Leu Met Lys Glu Pro Val Leu Gln Asp Lys Arg Ser 
785                 790                 795                 800 


Asp His Val Lys Phe Cys Lys Tyr Ala Ala Glu Leu Ile Glu Arg Val 
                805                 810                 815     


Ser Gly Lys Pro Leu Leu Ile Gly Xaa Asp Val Ser Leu Ala Arg Leu 
            820                 825                 830         


Gln Lys Ala Asp Val Val Ala Gln Ser Arg Ile Ser Phe Pro Glu Lys 
        835                 840                 845             


Glu Leu Leu Leu Leu Ile Arg Asn His Leu Ile Ser Lys Gly Leu Gly 
    850                 855                 860                 


Glu Xaa Ala Xaa Val Leu Xaa Lys Glu Ala Asp Leu Pro Met Xaa Ala 
865                 870                 875                 880 


Ala Ser His Ser Ser Ala Phe Xaa Pro Val Xaa Ala Ala Ala Ser Pro 
                885                 890                 895     


Val Ser Leu Pro Arg Xaa Pro Arg Ile Ala Asn Gly Ile Ala Xaa Arg 
            900                 905                 910         


Leu Gly Ser His Ala Ala Val Gly Ala Ser Ala Pro Ser Ala Pro Xaa 
        915                 920                 925             


Ala His Pro Gln Pro Arg Pro Pro Gln Gly Pro Leu Ala Leu Pro Gly 
    930                 935                 940                 


Pro Ser Tyr Ala Gly Asn Ser Pro Leu Ile Gly Arg Ile Ser Phe Ile 
945                 950                 955                 960 


Arg Glu Arg Pro Ser Pro Cys Asn Gly Arg Lys Ile Arg Val Leu Arg 
                965                 970                 975     


Gln Lys Ser Asp His Gly Ala Tyr Ser Gln Ser Pro Ala Ile Lys Lys 
            980                 985                 990         


Gln Leu Asp Arg His Leu Pro Ser  Pro Pro Xaa Leu Asp  Ser Ile Ile 
        995                 1000                 1005             


Xaa Glu  Tyr Leu Arg Glu Gln  His Ala Arg Cys Lys  Asn Pro Val 
    1010                 1015                 1020             


Ala Xaa  Cys Pro Pro Phe Ser  Leu Phe Xaa Pro His  Gln Cys Pro 
    1025                 1030                 1035             


Glu Pro  Lys Gln Arg Arg Gln  Ala Pro Ile Asn Phe  Xaa Ser Arg 
    1040                 1045                 1050             


Leu Asn  Arg Arg Ala Ser Phe  Pro Lys Tyr Gly Gly  Val Asp Gly 
    1055                 1060                 1065             


Gly Cys  Phe Asp Arg His Leu  Ile Phe Ser Arg Phe  Arg Pro Ile 
    1070                 1075                 1080             


Ser Val  Phe Arg Glu Ala Asn  Glu Asp Glu Ser Gly  Phe Xaa Cys 
    1085                 1090                 1095             


Cys Ala  Phe Ser Ala Arg Glu  Arg Phe Leu Met Leu  Gly Xaa Cys 
    1100                 1105                 1110             


Xaa Gly  Gln Leu Lys Leu Tyr  Asn Val Phe Ser Gly  Gln Glu Glu 
    1115                 1120                 1125             


Ala Ser  Tyr Asn Cys His Asn  Ser Ala Ile Xaa His  Leu Glu Pro 
    1130                 1135                 1140             


Ser Arg  Asp Gly Ser Leu Leu  Leu Xaa Ser Ala Xaa  Trp Ser Gln 
    1145                 1150                 1155             


Pro Leu  Ser Ala Leu Trp Gly  Met Lys Ser Val Phe  Asp Met Lys 
    1160                 1165                 1170             


His Ser  Phe Xaa Glu Asp His  Tyr Val Glu Phe Ser  Lys His Ser 
    1175                 1180                 1185             


Gln Asp  Arg Val Ile Gly Xaa  Lys Gly Asp Ile Ala  His Ile Tyr 
    1190                 1195                 1200             


Asp Ile  Gln Xaa Gly Asn Lys  Leu Leu Xaa Leu Phe  Asn Pro Asp 
    1205                 1210                 1215             


Leu Ala  Asn Asn Tyr Lys Arg  Asn Cys Ala Xaa Phe  Asn Pro Xaa 
    1220                 1225                 1230             


Asp Asp  Leu Val Leu Asn Asp  Gly Val Leu Trp Asp  Val Arg Ser 
    1235                 1240                 1245             


Ala Gln  Ala Ile His Lys Phe  Asp Lys Phe Asn Met  Asn Ile Ser 
    1250                 1255                 1260             


Gly Val  Phe His Pro Asn Gly  Leu Glu Val Ile Ile  Asn Xaa Glu 
    1265                 1270                 1275             


Ile Trp  Asp Leu Arg Xaa Phe  His Leu Leu His Xaa  Val Pro Ala 
    1280                 1285                 1290             


Leu Asp  Gln Cys Arg Val Val  Phe Asn His Xaa Gly  Xaa Val Met 
    1295                 1300                 1305             


Tyr Gly  Ala Met Leu Gln Ala  Asp Asp Glu Asp Asp  Leu Met Glu 
    1310                 1315                 1320             


Glu Arg  Met Lys Ser Pro Phe  Gly Ser Ser Phe Arg  Xaa Phe Asn 
    1325                 1330                 1335             


Ala Xaa  Asp Tyr Lys Pro Ile  Ala Xaa Ile Asp Val  Lys Arg Asn 
    1340                 1345                 1350             


Ile Phe  Asp Leu Cys Xaa Asp  Xaa Lys Asp Cys Tyr  Leu Ala Val 
    1355                 1360                 1365             


Ile Glu  Asn Gln Gly Ser Met  Asp Ala Leu Asn Met  Asp Xaa Val 
    1370                 1375                 1380             


Cys Arg  Leu Tyr Glu Val Gly  Arg Gln Arg Leu Ala  Glu Asp Glu 
    1385                 1390                 1395             


Asp Glu  Glu Glu Asp Gln Glu  Glu Glu Glu Gln Glu  Glu Glu Asp 
    1400                 1405                 1410             


Asp Asp  Glu Asp Asp Asp Asp  Xaa Asp Asp Leu Asp  Glu Leu Asp 
    1415                 1420                 1425             


Xaa Asp  Gln Leu Leu Glu Ala  Glu Leu Glu Glu Asp  Asp Asn Asn 
    1430                 1435                 1440             


Glu Asn  Ala Gly Glu Asp Gly  Asp Asn Asp Phe Ser  Pro Ser Asp 
    1445                 1450                 1455             


Glu Glu  Leu Ala Asn Leu Leu  Glu Glu Gly Glu Asp  Gly Glu Asp 
    1460                 1465                 1470             


Glu Asp  Ser Asp Ala Asp Glu  Glu Val Glu Leu Ile  Leu Gly Asp 
    1475                 1480                 1485             


Xaa Asp  Ser Ser Asp Asn Ser  Asp Leu Glu Asp Asp  Ile Ile Leu 
    1490                 1495                 1500             


Ser Leu  Asn Glu 
    1505         


<210> 7631
<211> 1506
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (15)..(16)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (144)..(144)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (255)..(256)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (321)..(321)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (388)..(388)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (460)..(460)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (491)..(491)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (519)..(519)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (563)..(563)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (618)..(618)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (630)..(630)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (705)..(705)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (748)..(748)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (769)..(769)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (824)..(824)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (865)..(865)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (867)..(867)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (870)..(870)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (901)..(901)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (927)..(927)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1002)..(1002)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1008)..(1008)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1024)..(1024)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1032)..(1032)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1050)..(1050)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1111)..(1111)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1113)..(1113)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1138)..(1138)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1151)..(1151)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1154)..(1154)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1176)..(1176)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1194)..(1194)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1206)..(1206)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1212)..(1212)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1228)..(1228)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1232)..(1232)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1276)..(1276)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1283)..(1283)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1289)..(1289)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1303)..(1303)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1305)..(1305)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1335)..(1335)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1339)..(1339)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1346)..(1346)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1358)..(1358)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1360)..(1360)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1420)..(1420)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1428)..(1428)
<223> Selenocysteine

<220>
<221> MOD_RES
<222> (1488)..(1488)
<223> Selenocysteine

<400> 7631
Met Xaa Xaa Val Val Val His Val Asp Ser Lys Ala Glu Leu Xaa Xaa 
1               5                   10                  15      


Leu Leu Glu Gln Trp Glu Lys Glu His Gly Ser Gly Gln Asp Met Val 
            20                  25                  30          


Pro Ile Leu Xaa Arg Met Ser Gln Leu Ile Glu Lys Glu Xaa Glu Glu 
        35                  40                  45              


Tyr Arg Lys Gly Asp Pro Asp Pro Phe Asp Asp Arg His Pro Gly Arg 
    50                  55                  60                  


Ala Asp Pro Glu Cys Met Leu Gly His Leu Leu Arg Ile Leu Phe Lys 
65                  70                  75                  80  


Asn Asp Asp Phe Met Asn Leu Val Asn Ala Tyr Val Met Xaa Ser Arg 
                85                  90                  95      


Glu Pro Pro Leu Asn Xaa Ala Ala Cys Arg Leu Leu Leu Asp Ile Met 
            100                 105                 110         


Pro Gly Leu Glu Xaa Ala Val Val Phe Gln Glu Lys G